Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	A	T	G	C	Cg	cG	tCw	wGa	tCa	tGa	tCt	aGa	tC	Ga	tCh	dGa	cC	Gg	wrC	Gyw	Cc	gG	wA	Tw	tC_mutation	tC_mutation_to_G	tC_mutation_to_T	APOBEC_mutation	APOBEC_mutation_to_G	APOBEC_mutation_to_T	"CONTEXT(+/-20)"	a_counts	t_counts	g_counts	c_counts	cg_counts	tcw_counts	wga_counts	tca_counts	tga_counts	tct_counts	aga_counts	tc_counts	ga_counts	tch_counts	dga_counts	cc_counts	gg_counts	wrc_counts	gyw_counts	cc_counts	gg_counts	wa_counts	tw_counts	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut	newbase	end	tum_allele1	tum_allele2	start	effect_idx	newbase_idx	pat_idx	is_coding	is_flank	is_indel	is_ins	is_del	is_missense	is_nonsense	is_splice	is_silent	gene_idx	context_and_effect	context65	categ_idx	trackpos	categ	gene	chr	pos	type	classification	ref_allele	patient	DistBetween_Mutations	Distance_to_LT_end	Distance_to_RT_end	Strain_Mutation_ID	Dataset_Mutation_ID	Complex_ID	Complex_Size	StrainCluster_ID	Dataset_Cluster_ID	Distance_Between_Clusters	Cluster_Size_Mutations	Cluster_Size_Complexes	Cluster_Length	Cluster_Coordination	Content_of_non_coordinated_cluster	Cluster_Pvalue
SLC2A7	155184	broad.mit.edu	37	chr1	9086388	9086388	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgggtggaggggttcccGcctctttgttctccatcctt	4	14	12	11	1	2	0	0	0	2	0	5	2	4	1	4	4	0	2	4	4	1	4	rs150973958	byFrequency	TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:9086388G>T	uc009vmo.1	-	1	17	c.17C>A	c.(16-18)GCG>GAG	p.A6E		NM_207420	NP_997303	Q6PXP3	GTR7_HUMAN	intestinal facilitative glucose transporter 7	6	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity				0	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		AGGGGTTCCCGCCTCTTTGTT	0.582													7	24					1.06961e-07	1.11489e-07	1	0	T	9086388	T	T	9086388	3	4	1	1	0	0	0	0	1	0	0	0	14614	1087	38	3	1569	3	SLC2A7	1	9086388	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08		9086388	240164233	1	1											
VPS13D	55187	broad.mit.edu	37	chr1	12423152	12423152	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccaatcccgaaggttacAtttccacccttcctggttcc	8	11	6	16	1	0	0	0	0	0	0	4	1	4	0	6	2	2	2	6	2	3	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:12423152A>T	uc001atv.2	+	52	10438	c.10297A>T	c.(10297-10299)ATT>TTT	p.I3433F	VPS13D_uc001atw.2_Missense_Mutation_p.I3408F|VPS13D_uc001atx.2_Missense_Mutation_p.I2620F	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3432					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CGAAGGTTACATTTCCACCCT	0.383													82	204					0	0	0	0	T	12423152	T	T	12423152	3	4	1	1	0	0	0	0	1	0	0	0	17260	217	8	5	10499	5	VPS13D	1	12423152	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	3336764	12423152	236827469	2	2											
KIAA0467	23334	broad.mit.edu	37	chr1	43908207	43908207	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcagaatgcacgagcccAtctcatcttctgcctactca	9	10	8	14	1	4	1	2	0	3	1	5	2	4	1	2	1	4	2	2	1	2	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:43908207A>T	uc001cjk.1	+	43	5834	c.5372A>T	c.(5371-5373)CAT>CTT	p.H1791L		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2690						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCACGAGCCCATCTCATCTTC	0.587													53	114					0	0	0	0	T	43908207	T	T	43908207	3	4	1	1	0	0	0	0	1	0	0	0	8217	217	8	5	5534	5	KIAA0467	1	43908207	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	31485055	43908207	205342414	3	3											
BEND5	79656	broad.mit.edu	37	chr1	49202065	49202065	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgtacttggaatctccttgGgttacttgtagctggtgcca	6	15	12	8	0	1	0	0	0	1	0	2	1	1	1	2	3	4	4	2	3	4	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:49202065G>C	uc001crx.3	-	5	998	c.954C>G	c.(952-954)ACC>ACG	p.T318T	AGBL4_uc001cru.2_Intron|AGBL4_uc010omw.1_Intron|AGBL4_uc010omx.1_Intron|AGBL4_uc001crv.1_Intron|AGBL4_uc010omy.1_Intron|BEND5_uc001crw.3_Silent_p.T149T	NM_024603	NP_078879	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	318	BEN.									skin(1)	1						AATCTCCTTGGGTTACTTGTA	0.468													6	234					0	0	0	0	C	49202065	C	C	49202065	2	2	1	1	0	0	0	0	0	0	0	1	1403	1219	43	4		4	BEND5	1	49202065	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08	5293858	49202065	200048556	4	4											
FAF1	11124	broad.mit.edu	37	chr1	51050366	51050367	+	Frame_Shift_Ins	INS	-	T	T																															taatactcactcattggagaINSttttctcaaggcagatgacg																										TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:51050366_51050367insT	uc009vyx.1	-	11	1020_1021	c.957_958insA	c.(955-960)AAATCTfs	p.K319fs	FAF1_uc009vyw.1_Intron|FAF1_uc001cse.1_Frame_Shift_Ins_p.K319fs|FAF1_uc010onc.1_Frame_Shift_Ins_p.K77fs	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	319_320					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		CTCATTGGAGATTTTCTCAAGG	0.376													---	---	---								T	51050367	T	T	51050366	7	5	1	1	0	1	1	0	0	0	0	0	5397	333	12	0	1034	0	FAF1	1	51050366	Frame_Shift_Ins	INS	-	TCGA-BA-4074-01A-01D-1434-08	1848301	51050366	198200255	5	5											
DIO1	1733	broad.mit.edu	37	chr1	54370406	54370406	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttatgttcaaatttgaccaGttcaagaggcttattgaaga	13	15	8	5	0	2	4	2	2	0	2	2	4	2	4	1	1	0	3	1	1	5	7			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:54370406G>A	uc010onx.1	+	3	428	c.405G>A	c.(403-405)CAG>CAA	p.Q135Q	DIO1_uc010onw.1_Silent_p.Q71Q|DIO1_uc009vzl.2_Intron|DIO1_uc001cwb.2_Intron|DIO1_uc010ony.1_Silent_p.Q135Q|DIO1_uc001cwd.2_RNA|DIO1_uc001cwe.2_Intron|DIO1_uc001cwf.2_RNA|DIO1_uc001cwg.2_RNA	NM_000792	NP_000783	P49895	IOD1_HUMAN	deiodinase, iodothyronine, type I isoform a	135					hormone biosynthetic process|thyroid hormone generation	endoplasmic reticulum membrane|integral to membrane|plasma membrane	selenium binding|thyroxine 5'-deiodinase activity				0						AATTTGACCAGTTCAAGAGGC	0.393													102	209					0	0	0	0	A	54370406	A	A	54370406	2	1	1	1	0	0	0	0	0	0	0	1	4546	1020	36	4		4	DIO1	1	54370406	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08	3320040	54370406	194880215	6	6											
PPAP2B	8613	broad.mit.edu	37	chr1	56990179	56990179	+	Frame_Shift_Del	DEL	C	-	-																															taggggttctgaatcgtcgaCcgcgacttcttcaggtaata																										TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:56990179delC	uc001cyj.1	-	4	846	c.345delG	c.(343-345)CGGfs	p.R115fs		NM_177414	NP_803133	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	115	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity				0						GAATCGTCGACCGCGACTTCT	0.483													---	---	---								-	56990179	-	-	56990179	7	5	1	1	0	1	0	1	0	0	0	0	12346	494	18	0	606	0	PPAP2B	1	56990179	Frame_Shift_Del	DEL	C	TCGA-BA-4074-01A-01D-1434-08	2619773	56990179	192260442	7	7											
LPHN2	23266	broad.mit.edu	37	chr1	82436053	82436053	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttctttttggcagcttttgCttggatgtgcctagaaggtg	5	18	12	6	0	1	1	0	0	1	1	1	2	1	2	1	3	3	3	1	3	2	7			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:82436053C>A	uc001dit.3	+	15	2919	c.2738C>A	c.(2737-2739)GCT>GAT	p.A913D	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.A913D|LPHN2_uc001div.2_Missense_Mutation_p.A913D|LPHN2_uc009wcd.2_Missense_Mutation_p.A913D|LPHN2_uc001diw.2_Missense_Mutation_p.A497D|LPHN2_uc009wce.1_5'UTR	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	926	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GCAGCTTTTGCTTGGATGTGC	0.358													67	230					6.52717e-41	7.22389e-41	1	0	A	82436053	A	A	82436053	3	1	1	1	0	0	0	0	1	0	0	0	8966	797	28	4	2788	4	LPHN2	1	82436053	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	25445874	82436053	166814568	8	8											
ARHGAP29	9411	broad.mit.edu	37	chr1	94645394	94645394	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atttctatacacatatttggCcattttttgtcttcaagact	10	19	4	8	0	3	1	1	0	2	1	3	1	3	1	1	1	1	0	1	1	4	9			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:94645394C>G	uc001dqj.3	-	20	2736	c.2367G>C	c.(2365-2367)TGG>TGC	p.W789C	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Missense_Mutation_p.W355C	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	789	Rho-GAP.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		ACATATTTGGCCATTTTTTGT	0.308													30	123					0	0	0	0	G	94645394	G	G	94645394	3	3	1	1	0	0	0	0	1	0	0	0	878	740	26	4	1434	4	ARHGAP29	1	94645394	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	12209341	94645394	154605227	9	9											
ARHGAP29	9411	broad.mit.edu	37	chr1	94697030	94697030	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatatcattcaccaactcCttgatgtaatccggatcaaa	13	12	5	11	1	3	2	3	2	0	0	5	3	5	3	3	1	1	1	3	1	4	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:94697030C>T	uc001dqj.3	-	2	507	c.138G>A	c.(136-138)AAG>AAA	p.K46K	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Silent_p.K46K	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	46					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TCACCAACTCCTTGATGTAAT	0.388													58	107					0	0	0	0	T	94697030	T	T	94697030	2	4	1	1	0	0	0	0	0	0	0	1	878	680	24	4		4	ARHGAP29	1	94697030	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	51636	94697030	154553591	10	10											
CELSR2	1952	broad.mit.edu	37	chr1	109795731	109795731	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgagccgggctacagtccaCgtccgcctccttgaccgcaa	7	7	11	16	4	0	2	0	2	0	0	3	2	3	2	6	1	2	2	6	1	2	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:109795731C>T	uc001dxa.3	+	1	3091	c.3030C>T	c.(3028-3030)CAC>CAT	p.H1010H		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1010	Extracellular (Potential).|Cadherin 8.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTACAGTCCACGTCCGCCTCC	0.577													22	112					0	0	0	0	T	109795731	T	T	109795731	2	4	1	1	0	0	0	0	0	0	0	1	3237	535	19	1		1	CELSR2	1	109795731	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	15098701	109795731	139454890	11	11											
SPAG17	200162	broad.mit.edu	37	chr1	118640342	118640342	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatcagctgctttgaccAtgtactcaagtcgagcaaca	14	9	8	10	1	2	1	2	1	0	0	3	3	2	1	1	0	5	4	1	0	5	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:118640342A>T	uc001ehk.2	-	7	1030	c.962T>A	c.(961-963)ATG>AAG	p.M321K		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	321						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TGCTTTGACCATGTACTCAAG	0.408													33	75					0	0	0	0	T	118640342	T	T	118640342	3	4	1	1	0	0	0	0	1	0	0	0	15045	217	8	5	5877	5	SPAG17	1	118640342	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	8844611	118640342	130610279	12	12											
NOTCH2NL	388677	broad.mit.edu	37	chr1	145290477	145290477	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcttacaagaaaaggaatCatactgctaagaattcaaac	19	8	6	8	0	2	2	2	0	0	2	2	3	2	3	0	1	5	2	0	1	9	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:145290477C>G	uc001emo.2	+	5	1053	c.683C>G	c.(682-684)TCA>TGA	p.S228*	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NOTCH2NL_uc010oyh.1_RNA|NBPF10_uc001end.3_5'Flank|NBPF10_uc001emq.1_5'Flank	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	Error:Variant_position_missing_in_Q7Z3S9_after_alignment					cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						GAAAAGGAATCATACTGCTAA	0.368													13	447					0	0	0	0	G	145290477	G	G	145290477	4	3	1	1	0	0	0	0	0	1	0	0	10603	841	29	2		2	NOTCH2NL	1	145290477	Nonsense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	26650135	145290477	103960144	13	13											
BCL9	607	broad.mit.edu	37	chr1	147086390	147086390	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccagccaaagtggtgtacGtgttttctactgagatggcc	8	12	11	10	1	1	1	0	1	1	1	2	2	2	1	3	2	3	2	3	2	3	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:147086390G>A	uc001epq.2	+	6	1275	c.535G>A	c.(535-537)GTG>ATG	p.V179M	BCL9_uc010ozr.1_Missense_Mutation_p.V105M	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	179					Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					AGTGGTGTACGTGTTTTCTAC	0.507			T	IGH@|IGL@	B-ALL								13	52					0	0	0	0	A	147086390	A	A	147086390	3	1	1	1	0	0	0	0	1	0	0	0	1383	1145	40	1	545	1	BCL9	1	147086390	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	1795913	147086390	102164231	14	14											
ECM1	1893	broad.mit.edu	37	chr1	150483454	150483454	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaagggggctggggccaccGgctggatggcttcccccctg	4	6	16	15	1	0	0	0	0	0	0	1	1	1	1	6	7	0	3	6	7	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:150483454G>A	uc001eus.2	+	6	687	c.488G>A	c.(487-489)CGG>CAG	p.R163Q	ECM1_uc010pce.1_Missense_Mutation_p.R92Q|ECM1_uc010pcf.1_Missense_Mutation_p.R85Q|ECM1_uc001eut.2_Missense_Mutation_p.R163Q|ECM1_uc001euu.2_Missense_Mutation_p.R192Q|ECM1_uc001euv.2_Missense_Mutation_p.R190Q|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	163	2 X approximate repeats.|1.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TGGGGCCACCGGCTGGATGGC	0.607													125	189					0	0	0	0	A	150483454	A	A	150483454	3	1	1	1	0	0	0	0	1	0	0	0	4919	1116	39	1	510	1	ECM1	1	150483454	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	3397064	150483454	98767167	15	15											
SETDB1	9869	broad.mit.edu	37	chr1	150935566	150935566	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtgatgatatccagaccatAtcctctggctctgaagggga	11	10	11	9	0	2	4	0	3	2	1	4	5	4	5	3	3	0	1	3	3	3	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:150935566A>G	uc001evu.2	+	19	3598	c.3408A>G	c.(3406-3408)ATA>ATG	p.I1136M	SETDB1_uc001evv.2_Missense_Mutation_p.I1136M|SETDB1_uc009wmg.1_Missense_Mutation_p.I1136M	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	1136	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCCAGACCATATCCTCTGGCT	0.498													26	82					0	0	0	0	G	150935566	G	G	150935566	3	3	1	1	0	0	0	0	1	0	0	0	14203	439	16	5	3478	5	SETDB1	1	150935566	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	452112	150935566	98315055	16	16											
DCST2	127579	broad.mit.edu	37	chr1	155004226	155004226	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgtgcaggagccactgcCacacattccggagagccctg	9	6	12	14	2	0	1	0	0	0	1	1	4	1	2	4	2	4	1	4	2	0	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:155004226C>T	uc001fgm.2	-	4	643	c.563G>A	c.(562-564)TGG>TAG	p.W188*	DCST2_uc009wpb.2_RNA|DCST1_uc010per.1_5'Flank|DCST1_uc001fgn.1_5'Flank|DCST1_uc010pes.1_5'Flank	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	188	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GAGCCACTGCCACACATTCCG	0.582													6	19					0	0	0	0	T	155004226	T	T	155004226	4	4	1	1	0	0	0	0	0	1	0	0	4320	595	21	4	1806	4	DCST2	1	155004226	Nonsense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	4068660	155004226	94246395	17	17											
OR10X1	128367	broad.mit.edu	37	chr1	158549182	158549182	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtctctgtaagagagataaAgaagcctgcagtgcaagcag	15	7	12	7	0	1	3	0	0	1	3	2	4	1	3	1	0	4	4	1	0	5	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:158549182A>G	uc010pin.1	-	1	508	c.508T>C	c.(508-510)TTT>CTT	p.F170L		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	170	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGAGAGATAAAGAAGCCTGCA	0.468													26	64					0	0	0	0	G	158549182	G	G	158549182	3	3	1	1	0	0	0	0	1	0	0	0	10976	72	3	5	467	5	OR10X1	1	158549182	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	3544956	158549182	90701439	18	18											
TOR1AIP2	163590	broad.mit.edu	37	chr1	179815800	179815800	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacttccgtcctctctgccaCaggaaggaactctggcctgg	8	9	10	14	1	2	0	0	0	2	0	5	2	4	2	4	4	3	0	4	4	3	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:179815800C>T	uc001gnk.2	-	6	1207	c.819G>A	c.(817-819)CTG>CTA	p.L273L	TOR1AIP2_uc001gnl.2_Silent_p.L273L	NM_145034	NP_659471	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	273						endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1						CTCTCTGCCACAGGAAGGAAC	0.522													28	139					0	0	0	0	T	179815800	T	T	179815800	2	4	1	1	0	0	0	0	0	0	0	1	16440	465	17	4		4	TOR1AIP2	1	179815800	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	21266618	179815800	69434821	19	19											
XPR1	9213	broad.mit.edu	37	chr1	180805685	180805685	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatttgccacaaatatacatAtggtgtgcgggccattgttc	11	13	9	8	1	0	0	0	0	0	0	1	0	0	0	2	2	3	1	2	2	5	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:180805685A>G	uc001goi.2	+	11	1526	c.1334A>G	c.(1333-1335)TAT>TGT	p.Y445C	XPR1_uc009wxm.2_Missense_Mutation_p.Y445C|XPR1_uc009wxn.2_Intron	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	445	Cytoplasmic (Potential).|EXS.					integral to plasma membrane	G-protein coupled receptor activity				0						AAATATACATATGGTGTGCGG	0.403													35	91					0	0	0	0	G	180805685	G	G	180805685	3	3	1	1	0	0	0	0	1	0	0	0	17519	449	16	5	1376	5	XPR1	1	180805685	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	989885	180805685	68444936	20	20											
ZBTB41	360023	broad.mit.edu	37	chr1	197145781	197145781	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcatatcttttatcatcatGatgtactcgtaagtgaagtc	11	16	6	8	1	4	2	3	2	1	0	6	2	4	2	0	0	1	2	0	0	5	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:197145781G>A	uc001gtx.1	-	7	1861	c.1792C>T	c.(1792-1794)CAT>TAT	p.H598Y	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TTATCATCATGATGTACTCGT	0.299													38	127					0	0	0	0	A	197145781	A	A	197145781	3	1	1	1	0	0	0	0	1	0	0	0	17610	1290	45	2	953	2	ZBTB41	1	197145781	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	16340096	197145781	52104840	21	21											
FMN2	56776	broad.mit.edu	37	chr1	240493929	240493929	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaaatggcccaggggttatGcaggttctaggtttggttct	9	13	13	6	0	2	0	0	0	2	0	2	0	2	0	1	6	1	5	1	6	4	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:240493929G>A	uc010pyd.1	+	11	4689	c.4464G>A	c.(4462-4464)ATG>ATA	p.M1488I	FMN2_uc010pye.1_Missense_Mutation_p.M1492I|FMN2_uc010pyf.1_Missense_Mutation_p.M134I|FMN2_uc010pyg.1_Missense_Mutation_p.M84I	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1488	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGGGGTTATGCAGGTTCTAG	0.388													27	106					0	0	0	0	A	240493929	A	A	240493929	3	1	1	1	0	0	0	0	1	0	0	0	5982	1319	46	4	4506	4	FMN2	1	240493929	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	43348148	240493929	8756692	22	22											
AKT3	10000	broad.mit.edu	37	chr1	243716166	243716166	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggttgtagaaaggtaacCtcccacacatcatttcatac	12	11	6	12	0	2	1	2	0	0	1	3	1	3	1	3	2	2	3	3	2	4	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr1:243716166C>A	uc001iab.1	-	10	1109	c.1028G>T	c.(1027-1029)AGG>ATG	p.R343M	AKT3_uc001hzz.1_Missense_Mutation_p.R343M	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	343	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GAAAGGTAACCTCCCACACAT	0.383													49	275					1.11015e-26	1.20828e-26	1	0	A	243716166	A	A	243716166	3	1	1	1	0	0	0	0	1	0	0	0	481	681	24	4	475	4	AKT3	1	243716166	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	3222237	243716166	5534455	23	23											
NCOA1	8648	broad.mit.edu	37	chr2	24905933	24905933	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaattaatgaatacgagcgtCtacagcatactgcacgtggg	13	9	11	8	3	1	1	0	1	1	0	1	3	1	1	0	1	6	2	0	1	6	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:24905933C>G	uc002rfk.2	+	6	726	c.468C>G	c.(466-468)GTC>GTG	p.V156V	NCOA1_uc010eye.2_Silent_p.V156V|NCOA1_uc002rfi.2_Silent_p.V5V|NCOA1_uc002rfj.2_Silent_p.V156V|NCOA1_uc002rfl.2_Silent_p.V156V	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	156	PAS.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATACGAGCGTCTACAGCATAC	0.373			T	PAX3	alveolar rhadomyosarcoma								27	84					0	0	0	0	G	24905933	G	G	24905933	2	3	1	1	0	0	0	0	0	0	0	1	10282	900	32	2		2	NCOA1	2	24905933	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08		24905933	218293440	24	24											
IFT172	26160	broad.mit.edu	37	chr2	27668659	27668659	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacctcaaagggaatgtctgTatcctgaaaatcagagtggt	13	10	10	8	0	3	2	2	1	1	1	4	3	4	3	2	2	0	1	2	2	5	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:27668659T>C	uc002rku.2	-	45	4918	c.4867A>G	c.(4867-4869)ACA>GCA	p.T1623A	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1623					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					GGAATGTCTGTATCCTGAAAA	0.542													48	118					0	0	0	0	C	27668659	C	C	27668659	3	2	1	1	0	0	0	0	1	0	0	0	7596	1638	57	5	398	5	IFT172	2	27668659	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	2762726	27668659	215530714	25	25											
PLEKHH2	130271	broad.mit.edu	37	chr2	43980883	43980883	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatctggcattagaaatggCagctcttttatctcaggtaa	12	13	9	7	0	3	2	1	0	3	2	4	2	3	2	0	3	1	4	0	3	4	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:43980883C>T	uc010yny.1	+	25	3862	c.3779C>T	c.(3778-3780)GCA>GTA	p.A1260V		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1260	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTAGAAATGGCAGCTCTTTTA	0.299													58	86					0	0	0	0	T	43980883	T	T	43980883	3	4	1	1	0	0	0	0	1	0	0	0	12132	710	25	4	3873	4	PLEKHH2	2	43980883	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	16312224	43980883	199218490	26	26											
REL	5966	broad.mit.edu	37	chr2	61118932	61118932	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggggagcacagcacagAcaacaaccgaacataccctt	15	4	8	14	1	0	1	0	0	0	1	1	3	1	2	3	2	6	2	3	2	4	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:61118932A>T	uc002sam.1	+	2	349	c.125A>T	c.(124-126)GAC>GTC	p.D42V	REL_uc002san.1_Missense_Mutation_p.D42V	NM_002908	NP_002899	Q04864	REL_HUMAN	v-rel reticuloendotheliosis viral oncogene	42	RHD.				positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			CACAGCACAGACAACAACCGA	0.413			A		Hodgkin Lymphoma								50	139					0	0	0	0	T	61118932	T	T	61118932	3	4	1	1	0	0	0	0	1	0	0	0	13280	275	10	5	131	5	REL	2	61118932	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	17138049	61118932	182080441	27	27											
ANKRD36	375248	broad.mit.edu	37	chr2	97779626	97779626	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatctagagaaactgaagtaCcttctgctcacgtattatga	14	12	7	8	1	3	3	1	2	2	1	3	4	3	3	1	0	3	3	1	0	7	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:97779626C>G	uc010yva.1	+	1	394	c.150C>G	c.(148-150)TAC>TAG	p.Y50*	ANKRD36_uc002sxn.2_Nonsense_Mutation_p.Y50*|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Nonsense_Mutation_p.Y50*|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	50	ANK 1.										0						AACTGAAGTACCTTCTGCTCA	0.517													29	56					0	0	0	0	G	97779626	G	G	97779626	4	3	1	1	0	0	0	0	0	1	0	0	665	518	18	4	152	4	ANKRD36	2	97779626	Nonsense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	36660694	97779626	145419747	28	28											
TBC1D8	11138	broad.mit.edu	37	chr2	101627939	101627939	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttcccgaaaaccaggggtCtcgatgttgacaacagagga	12	8	12	9	2	1	2	0	1	1	1	3	5	2	3	2	3	2	2	2	3	3	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:101627939C>G	uc010fiv.2	-	18	2977	c.2846G>C	c.(2845-2847)AGA>ACA	p.R949T	RPL31_uc010yvu.1_Intron|RPL31_uc010yvv.1_Intron|RPL31_uc010fiu.1_Intron|TBC1D8_uc002tau.3_Missense_Mutation_p.R706T	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	949					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						AACCAGGGGTCTCGATGTTGA	0.483													42	79					0	0	0	0	G	101627939	G	G	101627939	3	3	1	1	0	0	0	0	1	0	0	0	15691	913	32	2	588	2	TBC1D8	2	101627939	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	3848313	101627939	141571434	29	29											
PCDP1	200373	broad.mit.edu	37	chr2	120388230	120388230	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagacctcaaaagcttgccCgagccctaaagcaaggagct	14	5	9	13	1	1	1	1	0	0	1	1	3	1	2	3	1	5	3	3	1	5	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:120388230C>A	uc002tmb.2	+	19	2050	c.958C>A	c.(958-960)CGA>AGA	p.R320R	PCDP1_uc010yyq.1_Silent_p.R450R	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	606						cilium	calmodulin binding				0	Colorectal(110;0.196)					AAAGCTTGCCCGAGCCCTAAA	0.448													26	60					7.88262e-20	8.48567e-20	1	0	A	120388230	A	A	120388230	2	1	1	1	0	0	0	0	0	0	0	1	11626	644	23	3		3	PCDP1	2	120388230	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	18760291	120388230	122811143	30	30											
LRP1B	53353	broad.mit.edu	37	chr2	141083449	141083449	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaataatccacagccaaaccTgcaaaatcaacacacacaag	21	4	3	13	0	1	0	1	0	0	0	2	0	2	0	3	0	4	1	3	0	7	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:141083449T>A	uc002tvj.1	-	80	13196	c.12224_splice	c.e80-1	p.G4075_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGCCAAACCTGCAAAATCAA	0.348										TSP Lung(27;0.18)			19	35					0	0	0	0	A	141083449	A	A	141083449	5	1	1	1	0	0	0	0	0	0	1	0	9005	1594	55	5	1625	5	LRP1B	2	141083449	Splice_Site	SNP	T	TCGA-BA-4074-01A-01D-1434-08	20695219	141083449	102115924	31	31											
LRP1B	53353	broad.mit.edu	37	chr2	141777529	141777529	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaattcctctgggatgagaCatttcaccctctaaaagagt	13	11	7	10	0	3	2	1	1	2	2	4	4	4	3	2	1	0	0	2	1	3	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:141777529C>A	uc002tvj.1	-	12	2904	c.1932G>T	c.(1930-1932)ATG>ATT	p.M644I	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	644	Extracellular (Potential).|LDL-receptor class B 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGGGATGAGACATTTCACCCT	0.368										TSP Lung(27;0.18)			35	113					9.8876e-21	1.07025e-20	1	0	A	141777529	A	A	141777529	3	1	1	1	0	0	0	0	1	0	0	0	9005	478	17	4	12187	4	LRP1B	2	141777529	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	694080	141777529	101421844	32	32											
TNFAIP6	7130	broad.mit.edu	37	chr2	152235971	152235971	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatggatcctgtatccaaatCcagtcaaggaaaaaatacaa	19	8	6	8	0	1	0	1	0	0	0	4	2	4	2	3	2	1	1	3	2	9	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:152235971C>T	uc002txk.2	+	6	834	c.758C>T	c.(757-759)TCC>TTC	p.S253F		NM_007115	NP_009046	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	253					cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		GTATCCAAATCCAGTCAAGGA	0.338													62	165					0	0	0	0	T	152235971	T	T	152235971	3	4	1	1	0	0	0	0	1	0	0	0	16341	855	30	2	780	2	TNFAIP6	2	152235971	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	10458442	152235971	90963402	33	33											
PPP1R1C	151242	broad.mit.edu	37	chr2	182852607	182852607	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagcatcacttgtgattctCaatgagcataaccccccagg	11	9	7	14	0	2	2	2	2	1	0	3	2	2	2	4	1	3	2	4	1	2	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:182852607C>G	uc002uoo.2	+	2	410	c.123C>G	c.(121-123)CTC>CTG	p.L41L	PPP1R1C_uc002uon.2_Intron|PPP1R1C_uc002uop.1_Silent_p.L41L|PPP1R1C_uc010frm.1_Silent_p.L48L|PPP1R1C_uc010frn.1_RNA	NM_001080545	NP_001074014	Q8WVI7	PPR1C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	41					signal transduction	cytoplasm	protein phosphatase inhibitor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0628)			TTGTGATTCTCAATGAGCATA	0.408													86	189					0	0	0	0	G	182852607	G	G	182852607	2	3	1	1	0	0	0	0	0	0	0	1	12429	813	29	2		2	PPP1R1C	2	182852607	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	30616636	182852607	60346766	34	34											
ALS2CR4	65062	broad.mit.edu	37	chr2	202492078	202492078	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacagaagaaggtgtgtaaaGgtggattctgtcacttgtca	13	11	12	5	0	3	2	2	0	1	2	3	3	3	3	0	3	1	1	0	3	5	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:202492078G>A	uc002uyh.1	-	12	1104	c.1003C>T	c.(1003-1005)CTT>TTT	p.L335F	ALS2CR4_uc002uyg.1_Missense_Mutation_p.L327F|ALS2CR4_uc010zho.1_Missense_Mutation_p.L130F	NM_001044385	NP_001037850	Q96Q45	TM237_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	359						integral to membrane	protein binding				0						GGTGTGTAAAGGTGGATTCTG	0.333													3	15					0	0	0	0	A	202492078	A	A	202492078	3	1	1	1	0	0	0	0	1	0	0	0	554	1000	35	4	235	4	ALS2CR4	2	202492078	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	19639471	202492078	40707295	35	35											
WDR12	55759	broad.mit.edu	37	chr2	203760839	203760839	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacacttccagcatgaccTctacagcagtgtagggcttt	9	12	8	12	0	2	1	0	1	2	0	3	1	3	1	2	1	4	4	2	1	3	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:203760839T>A	uc002uzl.2	-	6	1308	c.558A>T	c.(556-558)AGA>AGT	p.R186S	WDR12_uc010ftt.2_Missense_Mutation_p.R186S	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	186	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						CAGCATGACCTCTACAGCAGT	0.378													53	129					0	0	0	0	A	203760839	A	A	203760839	3	1	1	1	0	0	0	0	1	0	0	0	17342	1548	54	5	745	5	WDR12	2	203760839	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	1268761	203760839	39438534	36	36											
ABCA12	26154	broad.mit.edu	37	chr2	215976352	215976352	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttggaggaaatttggtcCgagtaatagccaaaattatg	14	11	11	5	1	0	0	0	0	0	0	1	3	1	2	2	3	1	2	2	3	6	5	rs113648834		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:215976352C>T	uc002vew.2	-	2	351	c.131G>A	c.(130-132)CGG>CAG	p.R44Q	ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	44					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AAATTTGGTCCGAGTAATAGC	0.299													29	89					0	0	0	0	T	215976352	T	T	215976352	3	4	1	1	0	0	0	0	1	0	0	0	30	652	23	1	7895	1	ABCA12	2	215976352	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	12215513	215976352	27223021	37	37											
SPEG	10290	broad.mit.edu	37	chr2	220354645	220354645	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagaaaccctacaccttcCtggaggagaaagccaggcaa	14	5	9	13	0	1	2	1	0	0	2	2	4	2	3	4	3	3	1	4	3	4	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:220354645C>T	uc010fwg.2	+	36	8905	c.8905C>T	c.(8905-8907)CTG>TTG	p.L2969L		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2969	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTACACCTTCCTGGAGGAGAA	0.612													19	55					0	0	0	0	T	220354645	T	T	220354645	2	4	1	1	0	0	0	0	0	0	0	1	15102	680	24	4		4	SPEG	2	220354645	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	4378293	220354645	22844728	38	38											
UGT1A1	54658	broad.mit.edu	37	chr2	234669681	234669682	+	Frame_Shift_Ins	INS	-	GGACAGTCAC	GGACAGTCAC																															tgtccaggacctattgagctINSctgcatctgtctggctgttt																								rs57307513	byFrequency	TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:234669681_234669682insGGACAGTCAC	uc002vvb.2	+	1	763_764	c.748_749insGGACAGTCAC	c.(748-750)TCTfs	p.S250fs	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Frame_Shift_Ins_p.S250fs	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	250					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CCTATTGAGCTCTGCATCTGTC	0.47													---	---	---								GGACAGTCAC	234669682	GGACAGTCAC	GGACAGTCAC	234669681	7	5	1	1	0	1	1	0	0	0	0	0	17012	1551	54	0	750	0	UGT1A1	2	234669681	Frame_Shift_Ins	INS	-	TCGA-BA-4074-01A-01D-1434-08	14315036	234669681	8529692	39	39											
HJURP	55355	broad.mit.edu	37	chr2	234749404	234749404	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttgcagggaactgatggtcCctcgtgccatccctcgtgat	6	12	11	12	2	0	2	0	2	0	0	4	3	2	3	3	2	3	1	3	2	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr2:234749404C>T	uc002vvg.2	-	8	2088	c.2022G>A	c.(2020-2022)AGG>AGA	p.R674R	HJURP_uc010znd.1_Silent_p.R613R|HJURP_uc010zne.1_Silent_p.R582R	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	674					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		ACTGATGGTCCCTCGTGCCAT	0.577													48	107					0	0	0	0	T	234749404	T	T	234749404	2	4	1	1	0	0	0	0	0	0	0	1	7228	622	22	4		4	HJURP	2	234749404	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	79723	234749404	8449969	40	40											
PARP9	83666	broad.mit.edu	37	chr3	122269638	122269638	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaaacactccttcattgcAtgttttaatatctgcaggaa	12	14	5	10	0	2	0	1	0	1	0	4	1	4	1	2	1	3	3	2	1	4	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:122269638A>C	uc010hri.2	-	6	1369	c.1224T>G	c.(1222-1224)CAT>CAG	p.H408Q	PARP9_uc003eff.3_Missense_Mutation_p.H373Q|PARP9_uc011bjs.1_Missense_Mutation_p.H373Q|PARP9_uc003efg.2_Intron|PARP9_uc003efi.2_Missense_Mutation_p.H373Q|PARP9_uc003efh.2_Missense_Mutation_p.H408Q|PARP9_uc003efj.2_Missense_Mutation_p.H373Q	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	408	Macro 2.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		CCTTCATTGCATGTTTTAATA	0.378													23	64					0	0	0	0	C	122269638	C	C	122269638	3	2	1	1	0	0	0	0	1	0	0	0	11520	214	8	5	1417	5	PARP9	3	122269638	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08		122269638	75752792	41	41											
ROPN1	54763	broad.mit.edu	37	chr3	123695771	123695771	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccggttacacaaagcgacTcgctcagaccgctctctcac	9	7	8	17	4	3	1	2	0	1	1	5	2	3	1	2	1	2	3	2	1	2	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:123695771T>C	uc003eha.2	-	4	515	c.174A>G	c.(172-174)CGA>CGG	p.R58R		NM_017578	NP_060048	Q9HAT0	ROP1A_HUMAN	ropporin	58					signal transduction		cAMP-dependent protein kinase regulator activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.148)		ACAAAGCGACTCGCTCAGACC	0.517													44	106					0	0	0	0	C	123695771	C	C	123695771	2	2	1	1	0	0	0	0	0	0	0	1	13588	1538	54	5		5	ROPN1	3	123695771	Silent	SNP	T	TCGA-BA-4074-01A-01D-1434-08	1426133	123695771	74326659	42	42											
SNX4	8723	broad.mit.edu	37	chr3	125176125	125176125	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaccccagttaccagttcCtcacactgctgcttcttgga	7	12	6	16	0	3	0	2	0	1	0	4	1	4	1	4	1	3	4	4	1	1	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:125176125C>T	uc003eib.2	-	11	1071	c.1029G>A	c.(1027-1029)GAG>GAA	p.E343E	SNX4_uc011bkf.1_Silent_p.E198E	NM_003794	NP_003785	O95219	SNX4_HUMAN	sorting nexin 4	343					cell communication|endocytic recycling|endocytosis|protein transport	cytoplasmic dynein complex|early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4						TTACCAGTTCCTCACACTGCT	0.458													39	111					0	0	0	0	T	125176125	T	T	125176125	2	4	1	1	0	0	0	0	0	0	0	1	14968	680	24	4		4	SNX4	3	125176125	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	1480354	125176125	72846305	43	43											
COL6A6	131873	broad.mit.edu	37	chr3	130289727	130289727	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctctggcagtattgactatGatgagtataatatcatgaag	13	13	10	5	0	2	4	1	4	1	0	2	4	2	4	0	1	0	4	0	1	6	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:130289727G>C	uc010htl.2	+	6	2498	c.2467G>C	c.(2467-2469)GAT>CAT	p.D823H		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	823	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TATTGACTATGATGAGTATAA	0.398													30	84					0	0	0	0	C	130289727	C	C	130289727	3	2	1	1	0	0	0	0	1	0	0	0	3718	1290	45	2	2489	2	COL6A6	3	130289727	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	5113602	130289727	67732703	44	44											
TM4SF1	4071	broad.mit.edu	37	chr3	149089577	149089577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccaagagccaagaggataGaaaacagagatacattccat	19	5	8	9	0	0	4	0	0	0	4	1	6	1	5	3	1	3	0	3	1	6	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:149089577G>A	uc003exb.1	-	4	725	c.491C>T	c.(490-492)TCT>TTT	p.S164F	TM4SF1_uc003exc.1_Missense_Mutation_p.S75F	NM_014220	NP_055035	P30408	T4S1_HUMAN	transmembrane 4 superfamily member 1	164	Helical; (Probable).					integral to plasma membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CAAGAGGATAGAAAACAGAGA	0.433													46	90					0	0	0	0	A	149089577	A	A	149089577	3	1	1	1	0	0	0	0	1	0	0	0	16032	942	33	2	125	2	TM4SF1	3	149089577	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	18799850	149089577	48932853	45	45											
ACTL6A	86	broad.mit.edu	37	chr3	179291189	179291189	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atagtttccaagctattttgGatcatacctacaaaatgcat	14	14	5	8	0	1	0	1	0	0	0	2	1	2	1	2	1	4	3	2	1	7	7			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:179291189G>A	uc003fjw.2	+	4	483	c.310G>A	c.(310-312)GAT>AAT	p.D104N	ACTL6A_uc003fjx.2_Missense_Mutation_p.D62N|ACTL6A_uc003fjy.2_Missense_Mutation_p.D62N	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	104					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			AGCTATTTTGGATCATACCTA	0.358													40	98					0	0	0	0	A	179291189	A	A	179291189	3	1	1	1	0	0	0	0	1	0	0	0	198	1174	41	2	324	2	ACTL6A	3	179291189	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	30201612	179291189	18731241	46	46											
ATP13A4	84239	broad.mit.edu	37	chr3	193220338	193220338	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atactcctcatctgtcatgaGagggtggtcaggagtgagac	10	10	13	8	0	4	2	3	2	1	2	5	5	5	3	1	3	1	0	1	3	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr3:193220338G>C	uc003ftd.2	-	3	433	c.325C>G	c.(325-327)CTC>GTC	p.L109V	ATP13A4_uc003fte.1_Missense_Mutation_p.L109V|ATP13A4_uc011bsr.1_5'UTR	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	109	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TCTGTCATGAGAGGGTGGTCA	0.398													60	122					0	0	0	0	C	193220338	C	C	193220338	3	2	1	1	0	0	0	0	1	0	0	0	1128	942	33	2	3377	2	ATP13A4	3	193220338	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	13929149	193220338	4802092	47	47											
ADD1	118	broad.mit.edu	37	chr4	2896318	2896318	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttattttcaggttaagatcAatctacaaggagatatagta	15	15	7	4	0	3	2	2	0	1	2	3	3	3	2	0	2	1	2	0	2	8	9			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr4:2896318A>C	uc003gfr.2	+	6	789	c.601A>C	c.(601-603)AAT>CAT	p.N201H	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Missense_Mutation_p.N201H|ADD1_uc003gfo.2_Missense_Mutation_p.N201H|ADD1_uc003gfp.2_Missense_Mutation_p.N201H|ADD1_uc003gfq.2_Missense_Mutation_p.N201H|ADD1_uc003gfs.2_Missense_Mutation_p.N201H|ADD1_uc003gft.3_Missense_Mutation_p.N201H|ADD1_uc003gfu.2_5'UTR	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	201					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGTTAAGATCAATCTACAAGG	0.313													16	30					0	0	0	0	C	2896318	C	C	2896318	3	2	1	1	0	0	0	0	1	0	0	0	304	130	5	5	619	5	ADD1	4	2896318	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08		2896318	188257958	48	48											
NPFFR2	10886	broad.mit.edu	37	chr4	73012714	73012714	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggttccagtgtgtggtctacCcttttaaaccaaagctcact	9	13	8	11	0	2	0	1	0	1	0	3	0	3	0	3	2	3	2	3	2	4	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr4:73012714C>A	uc003hgg.2	+	4	852	c.754C>A	c.(754-756)CCT>ACT	p.P252T	NPFFR2_uc010iig.1_Missense_Mutation_p.P34T|NPFFR2_uc003hgi.2_Missense_Mutation_p.P153T|NPFFR2_uc003hgh.2_Missense_Mutation_p.P150T|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	252	Cytoplasmic (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TGTGGTCTACCCTTTTAAACC	0.378													98	280					3.77759e-48	4.20443e-48	1	0	A	73012714	A	A	73012714	3	1	1	1	0	0	0	0	1	0	0	0	10632	623	22	4	774	4	NPFFR2	4	73012714	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	70116396	73012714	118141562	49	49											
RAP1GDS1	5910	broad.mit.edu	37	chr4	99358174	99358174	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgagagaagtgctcctgaaAtcaaatataattccatggtc	15	11	8	7	0	1	3	1	2	0	1	4	4	3	3	2	1	1	1	2	1	5	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr4:99358174A>G	uc003htx.3	+	14	1841	c.1651A>G	c.(1651-1653)ATC>GTC	p.I551V	RAP1GDS1_uc003htw.3_Missense_Mutation_p.I552V|RAP1GDS1_uc003htv.3_Missense_Mutation_p.I551V|RAP1GDS1_uc003htz.3_Missense_Mutation_p.I502V|RAP1GDS1_uc003hty.3_Missense_Mutation_p.I503V|RAP1GDS1_uc003hua.3_Missense_Mutation_p.I460V	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	551							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		TGCTCCTGAAATCAAATATAA	0.343			T	NUP98	T-ALL								37	59					0	0	0	0	G	99358174	G	G	99358174	3	3	1	1	0	0	0	0	1	0	0	0	13104	101	4	5	1708	5	RAP1GDS1	4	99358174	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	26345460	99358174	91796102	50	50											
FBXO8	26269	broad.mit.edu	37	chr4	175160279	175160279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacgaaaaaattctctcagtGcatttggcaagaactgattt	14	12	8	7	1	2	2	1	1	1	1	3	4	2	2	0	1	2	2	0	1	5	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr4:175160279G>A	uc003itp.2	-	5	1488	c.638C>T	c.(637-639)GCA>GTA	p.A213V	FBXO8_uc003itq.2_Missense_Mutation_p.A172V	NM_012180	NP_036312	Q9NRD0	FBX8_HUMAN	F-box only protein 8	213	SEC7.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(2)	2		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		TTCTCTCAGTGCATTTGGCAA	0.378													17	80					0	0	0	0	A	175160279	A	A	175160279	3	1	1	1	0	0	0	0	1	0	0	0	5793	1319	46	4	329	4	FBXO8	4	175160279	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	75802105	175160279	15993997	51	51											
WDR17	116966	broad.mit.edu	37	chr4	177067239	177067239	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgaaagtatttagtgggcaTacagcaaaagtgtttcatgt	13	14	10	4	0	1	1	1	1	0	0	1	1	1	1	0	1	2	4	0	1	6	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr4:177067239T>C	uc003iuj.2	+	13	1851	c.1695T>C	c.(1693-1695)CAT>CAC	p.H565H	WDR17_uc003iuk.2_Silent_p.H541H|WDR17_uc003ium.3_Silent_p.H541H|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	565	WD 10.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TTAGTGGGCATACAGCAAAAG	0.388													40	166					0	0	0	0	C	177067239	C	C	177067239	2	2	1	1	0	0	0	0	0	0	0	1	17345	1403	49	5		5	WDR17	4	177067239	Silent	SNP	T	TCGA-BA-4074-01A-01D-1434-08	1906960	177067239	14087037	52	52											
PLEKHG4B	153478	broad.mit.edu	37	chr5	171356	171356	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcgggagctaggtgacaaaAtggacctggcctcctacctg	10	7	13	11	1	0	1	0	1	0	0	1	3	1	3	4	4	3	1	4	4	4	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:171356A>G	uc003jak.2	+	14	2829	c.2779A>G	c.(2779-2781)ATG>GTG	p.M927V		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	927	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGGTGACAAAATGGACCTGGC	0.697													46	19					0	0	0	0	G	171356	G	G	171356	3	3	1	1	0	0	0	0	1	0	0	0	12127	101	4	5	2833	5	PLEKHG4B	5	171356	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08		171356	180743904	53	53											
FASTKD3	79072	broad.mit.edu	37	chr5	7867445	7867445	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccacaatatcctccggggtaAatgtttccaatttttcacct	10	14	5	12	1	1	0	1	0	0	0	4	0	4	0	5	2	0	2	5	2	5	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:7867445A>T	uc003jeb.2	-	2	889	c.752T>A	c.(751-753)TTT>TAT	p.F251Y	FASTKD3_uc011cmp.1_5'UTR|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	251					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						CTCCGGGGTAAATGTTTCCAA	0.363													43	296					0	0	0	0	T	7867445	T	T	7867445	3	4	1	1	0	0	0	0	1	0	0	0	5719	14	1	5	1260	5	FASTKD3	5	7867445	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	7696089	7867445	173047815	54	54											
CDH10	1008	broad.mit.edu	37	chr5	24498538	24498538	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcattttcacatacaaaaGtgtcatagaacacagcaaac	17	9	6	9	0	2	1	2	0	0	1	2	1	2	1	0	1	4	2	0	1	6	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:24498538G>T	uc003jgr.1	-	9	1816	c.1484C>A	c.(1483-1485)ACT>AAT	p.T495N	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	495	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ACATACAAAAGTGTCATAGAA	0.393										HNSCC(23;0.051)			27	232					4.22769e-11	4.45377e-11	1	0	T	24498538	T	T	24498538	3	4	1	1	0	0	0	0	1	0	0	0	3111	1029	36	4	898	4	CDH10	5	24498538	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	16631093	24498538	156416722	55	55											
CDH10	1008	broad.mit.edu	37	chr5	24498580	24498580	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggggcattgtcattaacaTccaaaattctcacaaaaaca	16	10	6	9	0	2	0	2	0	1	0	4	0	3	0	1	2	2	1	1	2	5	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:24498580T>A	uc003jgr.1	-	9	1774	c.1442A>T	c.(1441-1443)GAT>GTT	p.D481V	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	481	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GTCATTAACATCCAAAATTCT	0.408										HNSCC(23;0.051)			33	238					0	0	0	0	A	24498580	A	A	24498580	3	1	1	1	0	0	0	0	1	0	0	0	3111	1435	50	5	940	5	CDH10	5	24498580	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	42	24498580	156416680	56	56											
PDZD2	23037	broad.mit.edu	37	chr5	32058193	32058193	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaggacaggatcgtcatggaAgtaacactcaacaaaggtga	17	6	11	7	1	2	1	2	1	0	0	3	4	2	4	0	4	2	1	0	4	5	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:32058193A>G	uc003jhl.2	+	12	2572	c.2184A>G	c.(2182-2184)GAA>GAG	p.E728E	PDZD2_uc003jhm.2_Silent_p.E728E|PDZD2_uc011cnx.1_Silent_p.E554E	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	728	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						TCGTCATGGAAGTAACACTCA	0.468													10	102					0	0	0	0	G	32058193	G	G	32058193	2	3	1	1	0	0	0	0	0	0	0	1	11755	69	3	5		5	PDZD2	5	32058193	Silent	SNP	A	TCGA-BA-4074-01A-01D-1434-08	7559613	32058193	148857067	57	57											
TRPC7	57113	broad.mit.edu	37	chr5	135587503	135587503	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcccgaaatctagcaggttCcacaagtgcagcacgtactc	12	8	8	13	2	1	0	0	0	1	0	4	1	3	0	2	1	4	5	2	1	4	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr5:135587503C>T	uc003lbn.1	-	5	1413	c.1410G>A	c.(1408-1410)TGG>TGA	p.W470*	TRPC7_uc010jef.1_Nonsense_Mutation_p.W407*|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Nonsense_Mutation_p.W401*|TRPC7_uc010jei.1_Nonsense_Mutation_p.W346*|TRPC7_uc010jej.1_Nonsense_Mutation_p.W22*	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	471	Helical; (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTAGCAGGTTCCACAAGTGCA	0.567													32	47					0	0	0	0	T	135587503	T	T	135587503	4	4	1	1	0	0	0	0	0	1	0	0	16651	856	30	2	1203	2	TRPC7	5	135587503	Nonsense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	103529310	135587503	45327757	58	58											
HIVEP1	3096	broad.mit.edu	37	chr6	12015862	12015862	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggccctgagtcaaagaagAtgcctcgaactaaacaaatt	17	7	8	9	1	1	3	1	1	0	2	2	4	1	3	2	1	3	0	2	1	7	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:12015862A>T	uc003nac.2	+	2	180	c.1A>T	c.(1-3)ATG>TTG	p.M1L		NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GTCAAAGAAGATGCCTCGAAC	0.358													33	103					0	0	0	0	T	12015862	T	T	12015862	3	4	1	1	0	0	0	0	1	0	0	0	7225	333	12	5	3	5	HIVEP1	6	12015862	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08		12015862	159099205	59	59											
SLC39A7	7922	broad.mit.edu	37	chr6	33171561	33171562	+	Frame_Shift_Ins	INS	-	T	T																															gctgctggggggagttatcaINStgatggtgctgattgcccac																										TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:33171561_33171562insT	uc003odf.2	+	8	1498_1499	c.1381_1382insT	c.(1381-1383)ATGfs	p.M461fs	RXRB_uc011dqr.1_5'Flank|SLC39A7_uc003odg.2_Frame_Shift_Ins_p.M461fs|SLC39A7_uc011dqv.1_Frame_Shift_Ins_p.M336fs|SLC39A7_uc003odh.2_Frame_Shift_Ins_p.M109fs|HSD17B8_uc003odi.1_5'Flank	NM_001077516	NP_001070984	Q92504	S39A7_HUMAN	solute carrier family 39, member 7	461				CALLTEGGAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLP ELLREASPLQSLLEVLGLLGGVIMMVLIAHLE -> VPFSL KEEQWTVKLQVVQVLAGSCHLLQVALST (in Ref. 1; BAA11528 and 2; AAD12305).		endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			large_intestine(1)	1						GGGAGTTATCATGATGGTGCTG	0.569													---	---	---								T	33171562	T	T	33171561	7	5	1	1	0	1	1	0	0	0	0	0	14687	217	8	0	1407	0	SLC39A7	6	33171561	Frame_Shift_Ins	INS	-	TCGA-BA-4074-01A-01D-1434-08	21155699	33171561	137943506	60	60											
GPR115	221393	broad.mit.edu	37	chr6	47682289	47682290	+	Frame_Shift_Ins	INS	-	T	T																															tggttgtgacggagatatcaINStacatgcgtcacgtgtgcat																										TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:47682289_47682290insT	uc003oza.1	+	6	1566_1567	c.1308_1309insT	c.(1306-1311)TCATACfs	p.S436fs	GPR115_uc003oyz.1_Frame_Shift_Ins_p.S493fs|GPR115_uc003ozb.1_Frame_Shift_Ins_p.S434fs	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	436_437	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						CGGAGATATCATACATGCGTCA	0.485													---	---	---								T	47682290	T	T	47682289	7	5	1	1	0	1	1	0	0	0	0	0	6670	204	8	0	1326	0	GPR115	6	47682289	Frame_Shift_Ins	INS	-	TCGA-BA-4074-01A-01D-1434-08	14510728	47682289	123432778	61	61											
MCM3	4172	broad.mit.edu	37	chr6	52129395	52129395	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acgaggcctcctcagatgagGaagatgatgccctcagacac	12	6	11	12	1	2	5	2	2	0	3	3	7	3	6	3	2	1	0	3	2	1	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:52129395G>T	uc003pan.1	-	17	2528	c.2418C>A	c.(2416-2418)TTC>TTA	p.F806L	MCM3_uc011dwu.1_Missense_Mutation_p.F760L	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	806					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					CTCAGATGAGGAAGATGATGC	0.542													36	112					3.62531e-18	3.88144e-18	1	0	T	52129395	T	T	52129395	3	4	1	1	0	0	0	0	1	0	0	0	9440	1165	41	2	12	2	MCM3	6	52129395	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	4447106	52129395	118985672	62	62											
KLHL31	401265	broad.mit.edu	37	chr6	53516534	53516534	+	Frame_Shift_Del	DEL	G	-	-																															tccgtccactcgttgagctcGgggctgaagcactggatgca																										TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:53516534delG	uc003pcb.3	-	3	1908	c.1767delC	c.(1765-1767)CCCfs	p.P589fs	uc003pcc.1_5'UTR	NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	589	Kelch 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					CGTTGAGCTCGGGGCTGAAGC	0.652											OREG0017507	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	53516534	-	-	53516534	7	5	1	1	0	1	0	1	0	0	0	0	8424	1103	39	0	141	0	KLHL31	6	53516534	Frame_Shift_Del	DEL	G	TCGA-BA-4074-01A-01D-1434-08	1387139	53516534	117598533	63	63											
BAI3	577	broad.mit.edu	37	chr6	69703805	69703805	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagatcctgagaaatgtgaCagacacatttaaaagggcaa	17	7	11	6	0	0	4	0	2	0	3	1	6	1	4	1	2	0	1	1	2	4	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:69703805C>A	uc003pev.3	+	11	2328	c.1880C>A	c.(1879-1881)ACA>AAA	p.T627K	BAI3_uc010kak.2_Missense_Mutation_p.T627K	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	627	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AGAAATGTGACAGACACATTT	0.443													46	122					1.17475e-09	1.23099e-09	1	0	A	69703805	A	A	69703805	3	1	1	1	0	0	0	0	1	0	0	0	1302	478	17	4	1914	4	BAI3	6	69703805	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	16187271	69703805	101411262	64	64											
ZNF292	23036	broad.mit.edu	37	chr6	87969654	87969654	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccagtttcccaatcccttGagtttccaacaagatacagt	12	11	6	12	0	0	2	0	1	0	1	3	2	3	2	4	0	3	2	4	0	4	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:87969654G>C	uc003plm.3	+	8	6348	c.6307G>C	c.(6307-6309)GAG>CAG	p.E2103Q		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CCAATCCCTTGAGTTTCCAAC	0.413													29	89					0	0	0	0	C	87969654	C	C	87969654	3	2	1	1	0	0	0	0	1	0	0	0	17893	1291	45	2	6337	2	ZNF292	6	87969654	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	18265849	87969654	83145413	65	65											
MDN1	23195	broad.mit.edu	37	chr6	90385185	90385185	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caactcatcagctgatacctGaggatgatccactgctcact	11	10	7	13	0	3	3	3	3	0	0	4	4	4	4	2	1	4	2	2	1	2	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:90385185G>A	uc003pnn.1	-	78	12875	c.12759C>T	c.(12757-12759)CTC>CTT	p.L4253L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4253					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GCTGATACCTGAGGATGATCC	0.527													29	69					0	0	0	0	A	90385185	A	A	90385185	2	1	1	1	0	0	0	0	0	0	0	1	9468	1277	45	2		2	MDN1	6	90385185	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08	2415531	90385185	80729882	66	66											
ASCC3	10973	broad.mit.edu	37	chr6	101037629	101037629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggccataagttagaggttCaatgctgcgattatcctatt	10	14	9	8	2	1	1	1	0	0	1	3	2	2	1	2	2	2	3	2	2	5	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:101037629C>T	uc003pqk.2	-	36	5760	c.5431G>A	c.(5431-5433)GAA>AAA	p.E1811K		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1811					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GTTAGAGGTTCAATGCTGCGA	0.343													61	160					0	0	0	0	T	101037629	T	T	101037629	3	4	1	1	0	0	0	0	1	0	0	0	1035	835	29	2	1205	2	ASCC3	6	101037629	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	10652444	101037629	70077438	67	67											
TRAF3IP2	10758	broad.mit.edu	37	chr6	111913273	111913273	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgattcatcaacctccacaGgaatgcttcggttcattcta	10	13	6	12	1	4	1	3	1	1	0	6	2	5	2	2	2	2	2	2	2	3	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr6:111913273G>A	uc011ebc.1	-	3	632	c.17C>T	c.(16-18)CCT>CTT	p.P6L	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.P6L|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.P6L|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.P6L|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.P6L	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	15					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		AACCTCCACAGGAATGCTTCG	0.423													48	125					0	0	0	0	A	111913273	A	A	111913273	3	1	1	1	0	0	0	0	1	0	0	0	16508	1000	35	4	1712	4	TRAF3IP2	6	111913273	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	10875644	111913273	59201794	68	68											
PAPOLB	56903	broad.mit.edu	37	chr7	4900071	4900071	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagactggatatcataggtGagatcaatgctgagaatttc	15	11	10	5	0	2	3	2	2	0	3	3	6	2	4	0	2	1	1	0	2	5	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr7:4900071G>A	uc003snk.2	-	1	1555	c.1371C>T	c.(1369-1371)CTC>CTT	p.L457L	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	456					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		TATCATAGGTGAGATCAATGC	0.363													92	122					0	0	0	0	A	4900071	A	A	4900071	2	1	1	1	0	0	0	0	0	0	0	1	11484	1277	45	2		2	PAPOLB	7	4900071	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08		4900071	154238592	69	69											
POU6F2	11281	broad.mit.edu	37	chr7	39247047	39247047	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccggcgtgatgccgggaggCcccccagccctcaaccagcc	6	3	13	19	3	1	1	1	1	0	0	1	2	1	2	8	3	4	0	8	3	1	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr7:39247047C>A	uc003thb.1	+	4	381	c.339C>A	c.(337-339)GGC>GGA	p.G113G	POU6F2_uc010kxo.2_Silent_p.G105G	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	113					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						TGCCGGGAGGCCCCCCAGCCC	0.577													79	200					1.31969e-37	1.45239e-37	1	0	A	39247047	A	A	39247047	2	1	1	1	0	0	0	0	0	0	0	1	12340	726	26	4		4	POU6F2	7	39247047	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	34346976	39247047	119891616	70	70											
STX1A	6804	broad.mit.edu	37	chr7	73115164	73115164	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactcgatcctgtcaatcaTctctccctgcggggccgggg	5	10	12	14	3	3	0	2	0	1	0	7	1	5	0	3	4	2	1	3	4	2	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr7:73115164T>A	uc003tyx.2	-	9	712	c.685A>T	c.(685-687)ATG>TTG	p.M229L	WBSCR22_uc003tyw.1_Intron|STX1A_uc003tyy.2_Intron|STX1A_uc010lbj.1_Missense_Mutation_p.D259V	NM_004603	NP_004594	Q16623	STX1A_HUMAN	syntaxin 1A isoform 1	229	Cytoplasmic (Potential).|t-SNARE coiled-coil homology.				energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CTGTCAATCATCTCTCCCTGC	0.627													13	23					0	0	0	0	A	73115164	A	A	73115164	3	1	1	1	0	0	0	0	1	0	0	0	15409	1435	50	5	189	5	STX1A	7	73115164	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	33868117	73115164	86023499	71	71											
MFHAS1	9258	broad.mit.edu	37	chr8	8750418	8750418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacgagctggggggaggcggGggactcgagcgcgtcggccc	5	3	21	12	6	0	0	0	0	0	0	2	4	0	2	1	7	2	1	1	7	0	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:8750418G>A	uc003wsj.1	-	1	714	c.151C>T	c.(151-153)CCC>TCC	p.P51S		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	51											0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GGGGAGGCGGGGGACTCGAGC	0.587													3	6					0	0	0	0	A	8750418	A	A	8750418	3	1	1	1	0	0	0	0	1	0	0	0	9574	1232	43	4	3019	4	MFHAS1	8	8750418	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08		8750418	137613604	72	72											
CSPP1	79848	broad.mit.edu	37	chr8	68102908	68102908	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacggtgagacatatcctGccattgaagatgacgtcctc	10	11	9	11	2	0	4	0	3	0	2	3	5	2	4	3	1	2	0	3	1	3	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:68102908G>A	uc003xxi.2	+	29	3365	c.3334G>A	c.(3334-3336)GCC>ACC	p.A1112T	ARFGEF1_uc003xxl.1_Intron|CSPP1_uc003xxj.2_Missense_Mutation_p.A1077T|CSPP1_uc003xxk.2_Missense_Mutation_p.A732T|CSPP1_uc010lyw.2_Missense_Mutation_p.A172T	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	1112						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			GACATATCCTGCCATTGAAGA	0.483													38	81					0	0	0	0	A	68102908	A	A	68102908	3	1	1	1	0	0	0	0	1	0	0	0	3979	1319	46	4	3448	4	CSPP1	8	68102908	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	59352490	68102908	78261114	73	73											
TERF1	7013	broad.mit.edu	37	chr8	73926133	73926133	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttttttcttttttagctaTtattcatggactatccagtc	7	22	4	8	0	2	0	1	0	1	0	4	1	3	1	1	1	1	1	1	1	4	10			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:73926133T>G	uc003xzd.2	+	2	348	c.323T>G	c.(322-324)ATT>AGT	p.I108S	TERF1_uc003xzc.2_RNA|TERF1_uc003xze.2_Missense_Mutation_p.I108S	NM_017489	NP_059523	P54274	TERF1_HUMAN	telomeric repeat binding factor 1 isoform 1	108	TRFH dimerization.				age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			ovary(1)|lung(1)|skin(1)	3	Breast(64;0.218)		Epithelial(68;0.0984)			TTTTTAGCTATTATTCATGGA	0.323													39	94					0	0	0	0	G	73926133	G	G	73926133	3	3	1	1	0	0	0	0	1	0	0	0	15827	1493	52	5	329	5	TERF1	8	73926133	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	5823225	73926133	72437889	74	74											
ZFHX4	79776	broad.mit.edu	37	chr8	77617964	77617964	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgttagggccagtggcagTgttgctagtaactatggcat	8	12	14	7	0	0	0	0	0	0	0	0	0	0	0	1	3	2	7	1	3	4	5	rs74886598		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:77617964T>C	uc003yav.2	+	2	2028	c.1641T>C	c.(1639-1641)AGT>AGC	p.S547S	ZFHX4_uc003yat.1_Silent_p.S547S|ZFHX4_uc003yau.1_Silent_p.S547S|ZFHX4_uc003yaw.1_Silent_p.S547S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	547						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAGTGGCAGTGTTGCTAGTA	0.488										HNSCC(33;0.089)			6	31					0	0	0	0	C	77617964	C	C	77617964	2	2	1	1	0	0	0	0	0	0	0	1	17702	1693	59	5		5	ZFHX4	8	77617964	Silent	SNP	T	TCGA-BA-4074-01A-01D-1434-08	3691831	77617964	68746058	75	75											
RUNX1T1	862	broad.mit.edu	37	chr8	92972691	92972691	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgagccacagtatcgggCtgtgttacagccactgcagg	11	8	12	10	1	0	1	0	1	0	0	1	1	0	1	2	2	4	4	2	2	3	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:92972691C>A	uc003yfd.2	-	11	1678	c.1594G>T	c.(1594-1596)GCC>TCC	p.A532S	RUNX1T1_uc003yfc.1_Missense_Mutation_p.A505S|RUNX1T1_uc003yfe.1_Missense_Mutation_p.A495S|RUNX1T1_uc010mao.2_Missense_Mutation_p.A505S|RUNX1T1_uc011lgi.1_Missense_Mutation_p.A543S|uc010mam.2_5'Flank|RUNX1T1_uc010man.1_Missense_Mutation_p.A157S|RUNX1T1_uc003yfb.1_Missense_Mutation_p.A495S	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	532	MYND-type.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAGTATCGGGCTGTGTTACAG	0.522													16	49					0.000422831	0.000431595	1	0	A	92972691	A	A	92972691	3	1	1	1	0	0	0	0	1	0	0	0	13812	797	28	4	224	4	RUNX1T1	8	92972691	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	15354727	92972691	53391331	76	76											
CSMD3	114788	broad.mit.edu	37	chr8	113697694	113697694	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtcagcctgaaattccaatCgcagtatgtgactattacta	12	12	8	9	1	1	2	1	2	0	0	3	2	2	2	2	1	2	2	2	1	6	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr8:113697694C>T	uc003ynu.2	-	15	2582	c.2423G>A	c.(2422-2424)CGA>CAA	p.R808Q	CSMD3_uc003yns.2_Missense_Mutation_p.R80Q|CSMD3_uc003ynt.2_Missense_Mutation_p.R768Q|CSMD3_uc011lhx.1_Missense_Mutation_p.R704Q	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	808	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAATTCCAATCGCAGTATGTG	0.408										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			36	97					0	0	0	0	T	113697694	T	T	113697694	3	4	1	1	0	0	0	0	1	0	0	0	3963	884	31	1	8928	1	CSMD3	8	113697694	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	20725003	113697694	32666328	77	77											
TRPM6	140803	broad.mit.edu	37	chr9	77397710	77397710	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaggatggccttgcgtgcCactccaaagctcagcaggac	11	6	12	12	1	1	0	1	0	0	0	2	3	2	2	3	3	4	2	3	3	2	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:77397710C>T	uc004ajl.1	-	22	3217	c.2979G>A	c.(2977-2979)GTG>GTA	p.V993V	TRPM6_uc004ajk.1_Silent_p.V988V|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_Silent_p.V279V	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	993	Helical; (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CCTTGCGTGCCACTCCAAAGC	0.438													33	33					0	0	0	0	T	77397710	T	T	77397710	2	4	1	1	0	0	0	0	0	0	0	1	16657	581	21	4		4	TRPM6	9	77397710	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08		77397710	63815721	78	78											
OR13C9	286362	broad.mit.edu	37	chr9	107380278	107380278	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtggtggtgtagcagatgtCcaagaaggagaggttcccca	10	8	16	7	0	0	3	0	0	0	3	2	4	2	3	3	5	1	3	3	5	3	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:107380278C>A	uc011lvr.1	-	1	208	c.208G>T	c.(208-210)GAC>TAC	p.D70Y		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TAGCAGATGTCCAAGAAGGAG	0.478													48	124					4.44712e-29	4.86713e-29	1	0	A	107380278	A	A	107380278	3	1	1	1	0	0	0	0	1	0	0	0	10993	855	30	2	751	2	OR13C9	9	107380278	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	29982568	107380278	33833153	79	79											
TNC	3371	broad.mit.edu	37	chr9	117848842	117848842	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatcacactcacaccgccCgtctacacagcggccacgat	11	6	6	18	4	4	0	3	0	1	0	4	1	4	0	3	1	2	0	3	1	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:117848842C>T	uc004bjj.3	-	3	1530	c.1168G>A	c.(1168-1170)GGG>AGG	p.G390R	TNC_uc010mvf.2_Missense_Mutation_p.G390R	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	390	EGF-like 8.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TCACACCGCCCGTCTACACAG	0.587													33	104					0	0	0	0	T	117848842	T	T	117848842	3	4	1	1	0	0	0	0	1	0	0	0	16336	652	23	1	5541	1	TNC	9	117848842	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	10468564	117848842	23364589	80	80											
GAPVD1	26130	broad.mit.edu	37	chr9	128112629	128112629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcggactctgttgccttcCcagtgctgacccattcaaca	7	11	8	15	1	2	1	1	1	1	0	3	2	3	2	3	1	4	2	3	1	1	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:128112629C>T	uc010mwx.2	+	22	3735	c.3409C>T	c.(3409-3411)CCA>TCA	p.P1137S	GAPVD1_uc004bpp.2_Missense_Mutation_p.P1146S|GAPVD1_uc004bpq.2_Missense_Mutation_p.P1119S|GAPVD1_uc004bpr.2_Missense_Mutation_p.P1098S|GAPVD1_uc004bps.2_Missense_Mutation_p.P1092S|GAPVD1_uc004bpt.2_Missense_Mutation_p.P152S	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1137					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TGTTGCCTTCCCAGTGCTGAC	0.383													99	87					0	0	0	0	T	128112629	T	T	128112629	3	4	1	1	0	0	0	0	1	0	0	0	6274	623	22	4	3514	4	GAPVD1	9	128112629	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	10263787	128112629	13100802	81	81											
ST6GALNAC6	30815	broad.mit.edu	37	chr9	130652958	130652958	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagaggtcgtcaaattgcCgcatgcggccgggagagacg	10	5	17	9	5	1	2	1	0	0	2	2	5	1	4	2	4	2	1	2	4	2	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:130652958C>T	uc004bso.1	-	5	781	c.662G>A	c.(661-663)CGG>CAG	p.R221Q	ST6GALNAC6_uc004bsn.1_Missense_Mutation_p.R187Q|ST6GALNAC6_uc011man.1_Intron|ST6GALNAC6_uc004bsp.1_Missense_Mutation_p.R221Q|ST6GALNAC6_uc004bsq.1_Missense_Mutation_p.R187Q|ST6GALNAC6_uc004bsr.2_Missense_Mutation_p.R187Q|ST6GALNAC6_uc010mxp.1_RNA	NM_013443	NP_038471	Q969X2	SIA7F_HUMAN	sialytransferase 7F	221	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane|plasma membrane					0						GTCAAATTGCCGCATGCGGCC	0.642													69	54					0	0	0	0	T	130652958	T	T	130652958	3	4	1	1	0	0	0	0	1	0	0	0	15294	652	23	1	351	1	ST6GALNAC6	9	130652958	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	2540329	130652958	10560473	82	82											
SEC16A	9919	broad.mit.edu	37	chr9	139339534	139339534	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctggctcacttcacgtgaTaatgaactcattgaactaca	12	12	7	10	1	3	3	3	3	0	0	3	3	3	3	0	1	4	2	0	1	4	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:139339534T>C	uc004chx.2	-	30	7206	c.6897A>G	c.(6895-6897)TTA>TTG	p.L2299L	SEC16A_uc004chp.2_Intron|SEC16A_uc004chq.2_Intron|SEC16A_uc011mea.1_Intron|SEC16A_uc004chr.2_Silent_p.L327L|SEC16A_uc004chs.2_Silent_p.L139L|SEC16A_uc004cht.2_Silent_p.L349L|SEC16A_uc004chu.2_Silent_p.L506L|SEC16A_uc004chv.3_Intron|SEC16A_uc004chw.2_Silent_p.L2274L|SEC16A_uc010nbn.2_Intron	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	2121	Required for interaction with SEC23A.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CTTCACGTGATAATGAACTCA	0.498													7	9					0	0	0	0	C	139339534	C	C	139339534	2	2	1	1	0	0	0	0	0	0	0	1	14051	1403	49	5		5	SEC16A	9	139339534	Silent	SNP	T	TCGA-BA-4074-01A-01D-1434-08	8686576	139339534	1873897	83	83											
MAN1B1	11253	broad.mit.edu	37	chr9	139990687	139990687	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgaccaatttctctacAgaagacacaaagacacatcc	15	9	6	11	0	1	4	0	1	1	3	3	4	2	4	2	0	1	0	2	0	4	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:139990687A>C	uc004cld.2	+	4	501	c.466_splice	c.e4-2	p.K156_splice	MAN1B1_uc004clc.2_Splice_Site_p.K57_splice|MAN1B1_uc011meo.1_Splice_Site_p.K57_splice|MAN1B1_uc011mep.1_Splice_Site_p.K156_splice|MAN1B1_uc010ncc.2_Splice_Site	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase						oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		ATTTCTCTACAGAAGACACAA	0.567													8	22					0	0	0	0	C	139990687	C	C	139990687	5	2	1	1	0	0	0	0	0	0	1	0	9265	202	7	5	478	5	MAN1B1	9	139990687	Splice_Site	SNP	A	TCGA-BA-4074-01A-01D-1434-08	651153	139990687	1222744	84	84											
MRPL41	64975	broad.mit.edu	37	chr9	140446898	140446898	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtacggcttcgagcccaCacaggagggaaagctcttcc	12	6	11	12	2	1	0	0	0	1	0	3	3	2	2	2	3	3	3	2	3	3	3	rs3210506		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:140446898C>A	uc004cnh.3	+	2	495	c.365C>A	c.(364-366)ACA>AAA	p.T122K	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	122					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		TTCGAGCCCACACAGGAGGGA	0.592													4	76					0.00024832	0.000254787	1	0	A	140446898	A	A	140446898	3	1	1	1	0	0	0	0	1	0	0	0	9858	478	17	4	367	4	MRPL41	9	140446898	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	456211	140446898	766533	85	85											
WDR85	92715	broad.mit.edu	37	chr9	140473185	140473185	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccactccaccgagtccgcGgtcagctcggtgtccaccgt	6	7	10	18	5	1	0	1	0	0	0	5	1	4	0	6	2	1	1	6	2	0	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr9:140473185G>A	uc004cnk.1	-	1	203	c.45C>T	c.(43-45)ACC>ACT	p.T15T	WDR85_uc004cnl.1_5'UTR|WDR85_uc004cnm.1_5'UTR|WDR85_uc004cnn.1_5'UTR	NM_138778	NP_620133	Q9BTV6	WDR85_HUMAN	WD repeat domain 85	15					peptidyl-diphthamide biosynthetic process from peptidyl-histidine						0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.00029)|Epithelial(140;0.000509)		CCGAGTCCGCGGTCAGCTCGG	0.746													7	2					0	0	0	0	A	140473185	A	A	140473185	2	1	1	1	0	0	0	0	0	0	0	1	17401	1103	39	1		1	WDR85	9	140473185	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08	26287	140473185	740246	86	86											
KIF5B	3799	broad.mit.edu	37	chr10	32326241	32326241	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcagcttttgttccgtttGtgtgttctcttgtttgacat	4	21	8	8	1	2	1	1	1	1	0	4	1	3	1	1	0	1	5	1	0	0	7			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr10:32326241G>C	uc001iwe.3	-	8	1122	c.652C>G	c.(652-654)CAA>GAA	p.Q218E		NM_004521	NP_004512	P33176	KINH_HUMAN	kinesin family member 5B	218	Kinesin-motor.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)				TGTTCCGTTTGTGTGTTCTCT	0.313													10	120					0	0	0	0	C	32326241	C	C	32326241	3	2	1	1	0	0	0	0	1	0	0	0	8345	1386	48	4	2311	4	KIF5B	10	32326241	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08		32326241	103208506	87	87											
PTEN	5728	broad.mit.edu	37	chr10	89711893	89711893	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggagtaactattcccagtCagaggcgctatgtgtattat	11	12	11	7	1	1	1	1	0	0	1	2	2	2	2	1	2	1	3	1	2	5	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr10:89711893C>T	uc001kfb.2	+	7	1542	c.511C>T	c.(511-513)CAG>TAG	p.Q171*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	171	Phosphatase tensin-type.			Q->A,E: 75% reduction in phosphatase activity towards PtdIns(3,4,5)P3.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.Q171*(9)|p.R55fs*1(4)|p.V166fs*17(3)|p.?(3)|p.G165fs*9(3)|p.Y27_N212>Y(2)|p.Q171P(2)|p.Y27fs*1(2)|p.Q171E(2)|p.V166fs*10(1)|p.G165_K342del(1)|p.G165_*404del(1)|p.Q171H(1)|p.S170fs*8(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TATTCCCAGTCAGAGGCGCTA	0.353		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			70	105					0	0	0	0	T	89711893	T	T	89711893	4	4	1	1	0	0	0	0	0	1	0	0	12800	827	29	2	533	2	PTEN	10	89711893	Nonsense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	57385652	89711893	45822854	88	88											
TIAL1	7073	broad.mit.edu	37	chr10	121336662	121336662	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaccacatgtccttcaatcGtagtaccgttcaccgaaaca	13	10	5	13	3	2	0	2	0	0	0	4	1	3	0	4	0	3	3	4	0	5	5	rs148932828	byFrequency	TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr10:121336662G>A	uc001lei.1	-	10	1355	c.791C>T	c.(790-792)ACG>ATG	p.T264M	TIAL1_uc001leh.1_Missense_Mutation_p.T242M|TIAL1_uc001lej.1_Missense_Mutation_p.T281M|TIAL1_uc001lek.1_Missense_Mutation_p.T141M|TIAL1_uc009xzi.1_Missense_Mutation_p.T133M|TIAL1_uc010qtb.1_Missense_Mutation_p.T141M	NM_003252	NP_003243	Q01085	TIAR_HUMAN	TIA-1 related protein isoform 1	264	RRM 3.				apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		TCCTTCAATCGTAGTACCGTT	0.348													36	34					0	0	0	0	A	121336662	A	A	121336662	3	1	1	1	0	0	0	0	1	0	0	0	15955	1145	40	1	348	1	TIAL1	10	121336662	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	31624769	121336662	14198085	89	89											
LRRC27	80313	broad.mit.edu	37	chr10	134188714	134188714	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cattttttaacacaaaatatGgagaatcaggaaatgttcgc	16	12	7	6	1	1	1	1	0	0	1	2	3	1	2	0	2	1	1	0	2	6	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr10:134188714G>A	uc010quw.1	+	11	1756	c.1561G>A	c.(1561-1563)GGA>AGA	p.G521R	LRRC27_uc001llg.2_RNA|LRRC27_uc001lli.2_Missense_Mutation_p.G521R|LRRC27_uc001llj.2_Missense_Mutation_p.G459R	NM_030626	NP_085129	Q9C0I9	LRC27_HUMAN	leucine rich repeat containing 27 isoform a	521										ovary(1)	1		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		CACAAAATATGGAGAATCAGG	0.522													20	25					0	0	0	0	A	134188714	A	A	134188714	3	1	1	1	0	0	0	0	1	0	0	0	9031	1349	47	4	1781	4	LRRC27	10	134188714	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	12852052	134188714	1346033	90	90											
ODF3	113746	broad.mit.edu	37	chr11	195956	195957	+	5'Flank	INS	-	A	A																															tgggggggaccttggtgaggINSggacctggtgaggggacata																								rs111730765		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:195956_195957insA	uc001lob.2	+						ODF3_uc010qvk.1_5'Flank|ODF3_uc001loc.2_5'Flank	NM_053280	NP_444510	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm				ovary(1)	1		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCTTGGTGAGGGGACCTGGTGA	0.653													---	---	---								A	195957	A	A	195956	6	5	1	0	1	1	1	0	0	0	0	0	10883	1247	43	0		0	ODF3	11	195956	5'Flank	INS	-	TCGA-BA-4074-01A-01D-1434-08		195956	134810560	91	91											
PKP3	11187	broad.mit.edu	37	chr11	404005	404005	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgtgggtgagaagtcgcccCcagccgaggtgctggtcaac	7	6	16	12	3	1	1	1	1	0	1	2	3	1	1	3	3	3	1	3	3	2	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:404005C>T	uc001lpc.2	+	11	2216	c.2140C>T	c.(2140-2142)CCA>TCA	p.P714S		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	714	ARM 8.				cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAAGTCGCCCCCAGCCGAGGT	0.627													24	70					0	0	0	0	T	404005	T	T	404005	3	4	1	1	0	0	0	0	1	0	0	0	12041	623	22	4	2182	4	PKP3	11	404005	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	208049	404005	134602511	92	92											
MUC5B	727897	broad.mit.edu	37	chr11	1155707	1155707	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggagtcagcggcccccaCgctgagcagggtcctcatga	8	5	13	15	2	2	2	2	2	0	0	3	3	3	3	4	3	2	2	4	3	0	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:1155707C>T	uc009ycr.1	+	5	521	c.395C>T	c.(394-396)ACG>ATG	p.T132M		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCGGCCCCCACGCTGAGCAGG	0.632													13	28					0	0	0	0	T	1155707	T	T	1155707	3	4	1	1	0	0	0	0	1	0	0	0	10032	551	19	1		1	MUC5B	11	1155707	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	751702	1155707	133850809	93	93											
OR51B2	79345	broad.mit.edu	37	chr11	5344959	5344959	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtaaagtctattgaaagttAtgtcagcacaagccagtctc	13	11	9	8	0	3	1	1	1	2	0	4	1	3	1	1	1	2	3	1	1	6	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:5344959A>C	uc001mao.1	-	1	624	c.569T>G	c.(568-570)ATA>AGA	p.I190R	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTGAAAGTTATGTCAGCACA	0.353													25	48					0	0	0	0	C	5344959	C	C	5344959	3	2	1	1	0	0	0	0	1	0	0	0	11143	449	16	5	373	5	OR51B2	11	5344959	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	4189252	5344959	129661557	94	94											
OR56A3	390083	broad.mit.edu	37	chr11	5969347	5969347	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcctcttcttcagcacCatccttctggtttttgtcct	4	18	4	15	0	5	0	2	0	3	0	8	0	8	0	4	1	1	2	4	1	0	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:5969347C>T	uc010qzt.1	+	1	771	c.771C>T	c.(769-771)ACC>ACT	p.T257T		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTTCAGCACCATCCTTCTGG	0.527													65	227					0	0	0	0	T	5969347	T	T	5969347	2	4	1	1	0	0	0	0	0	0	0	1	11188	581	21	4		4	OR56A3	11	5969347	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	624388	5969347	129037169	95	95											
OR5P2	120065	broad.mit.edu	37	chr11	7817968	7817969	+	Frame_Shift_Ins	INS	-	A	A																															gtaagggagcgaaatcacagINSaaaaaatgattgacttgatt																										TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:7817968_7817969insA	uc001mfp.1	-	1	521_522	c.521_522insT	c.(520-522)TTCfs	p.F174fs		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CGAAATCACAGAAAAAATGATT	0.386													---	---	---								A	7817969	A	A	7817968	7	5	1	1	0	1	1	0	0	0	0	0	11232	933	33	0	450	0	OR5P2	11	7817968	Frame_Shift_Ins	INS	-	TCGA-BA-4074-01A-01D-1434-08	1848621	7817968	127188548	96	96											
PAX6	5080	broad.mit.edu	37	chr11	31816281	31816281	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcctcatctgaatcttctccGttggaactgatggagttggt	7	14	11	9	1	4	2	1	2	3	0	5	4	4	4	2	3	1	2	2	3	2	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:31816281G>A	uc001mtd.3	-	7	1469	c.579C>T	c.(577-579)AAC>AAT	p.N193N	PAX6_uc001mte.3_Silent_p.N193N|PAX6_uc001mtg.3_Silent_p.N207N|PAX6_uc001mtf.3_Silent_p.N193N|PAX6_uc001mth.3_Silent_p.N193N|PAX6_uc009yjr.2_Silent_p.N193N	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	193	Gln/Gly-rich.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					AATCTTCTCCGTTGGAACTGA	0.453									Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				34	101					0	0	0	0	A	31816281	A	A	31816281	2	1	1	1	0	0	0	0	0	0	0	1	11537	1136	40	1		1	PAX6	11	31816281	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08	23998313	31816281	103190235	97	97											
OR4C46	119749	broad.mit.edu	37	chr11	51515476	51515476	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttccctggcctatctctcCtttattgatgcctgctattc	4	18	5	14	0	1	1	0	1	1	0	5	1	3	1	4	1	2	1	4	1	3	7			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:51515476C>T	uc010ric.1	+	1	195	c.195C>T	c.(193-195)TCC>TCT	p.S65S		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCTATCTCTCCTTTATTGATG	0.478													87	287					0	0	0	0	T	51515476	T	T	51515476	2	4	1	1	0	0	0	0	0	0	0	1	11105	668	24	4		4	OR4C46	11	51515476	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	19699195	51515476	83491040	98	98											
RTN4RL2	349667	broad.mit.edu	37	chr11	57243919	57243919	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctaacccctgggcgtgcgaCtgccgcgcgcggccgctctg	3	6	15	17	7	1	0	0	0	1	0	1	1	1	0	4	2	3	2	4	2	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:57243919C>G	uc010rjt.1	+	3	798	c.798C>G	c.(796-798)GAC>GAG	p.D266E		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	266	LRRCT.				axon regeneration	anchored to plasma membrane	receptor activity				0						GGGCGTGCGACTGCCGCGCGC	0.741													4	17					0	0	0	0	G	57243919	G	G	57243919	3	3	1	1	0	0	0	0	1	0	0	0	13797	564	20	4	808	4	RTN4RL2	11	57243919	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	5728443	57243919	77762597	99	99											
KDM2A	22992	broad.mit.edu	37	chr11	66985219	66985219	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caggtcttctggctcatcccCcctacagcccacaacctgga	8	8	7	18	0	3	0	1	0	2	0	4	1	4	1	5	3	3	1	5	3	2	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:66985219C>T	uc001ojw.2	+	9	1569	c.705C>T	c.(703-705)CCC>CCT	p.P235P	KDM2A_uc001ojx.2_RNA|KDM2A_uc001ojy.2_Intron	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	235	JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						GGCTCATCCCCCCTACAGCCC	0.483													5	39					0	0	0	0	T	66985219	T	T	66985219	2	4	1	1	0	0	0	0	0	0	0	1	8163	610	22	4		4	KDM2A	11	66985219	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	9741300	66985219	68021297	100	100											
ANO1	55107	broad.mit.edu	37	chr11	70028647	70028647	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtctgacttcatcccgcgcCtggtgtacctctacatgtac	6	12	8	15	3	3	1	1	1	2	0	4	1	4	1	3	1	3	2	3	1	3	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:70028647C>T	uc001opj.2	+	24	2748	c.2443C>T	c.(2443-2445)CTG>TTG	p.L815L	ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Silent_p.L524L|ANO1_uc010rql.1_5'UTR	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	815	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CATCCCGCGCCTGGTGTACCT	0.617													23	322					0	0	0	0	T	70028647	T	T	70028647	2	4	1	1	0	0	0	0	0	0	0	1	695	680	24	4		4	ANO1	11	70028647	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	3043428	70028647	64977869	101	101											
STARD10	10809	broad.mit.edu	37	chr11	72468875	72468875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggccctgtgctctggatgaGgtagcccgtctggatggaca	6	9	16	10	1	2	1	0	1	2	0	2	4	2	4	2	5	2	2	2	5	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:72468875G>A	uc001osy.2	-	5	805	c.514C>T	c.(514-516)CTC>TTC	p.L172F	ARAP1_uc001osv.2_Intron|STARD10_uc001osz.3_Missense_Mutation_p.L172F|STARD10_uc001ota.2_Missense_Mutation_p.L126F|STARD10_uc001otb.2_Missense_Mutation_p.L172F	NM_006645	NP_006636	Q9Y365	PCTL_HUMAN	START domain containing 10	172	START.										0			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			CTCTGGATGAGGTAGCCCGTC	0.612													35	47					0	0	0	0	A	72468875	A	A	72468875	3	1	1	1	0	0	0	0	1	0	0	0	15321	1000	35	4	373	4	STARD10	11	72468875	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	2440228	72468875	62537641	102	102											
KDM4DL	390245	broad.mit.edu	37	chr11	94759470	94759470	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggccctcatctcgcctacagTtctcaaggaaaatgggattc	10	10	9	12	1	3	0	2	0	2	0	6	2	3	2	2	3	1	1	2	3	4	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr11:94759470T>C	uc010ruf.1	+	1	1049	c.749T>C	c.(748-750)GTT>GCT	p.V250A		NM_001161630	NP_001155102	B2RXH2	KD4DL_HUMAN	lysine (K)-specific demethylase 4D-like	250	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TCGCCTACAGTTCTCAAGGAA	0.567													16	19					0	0	0	0	C	94759470	C	C	94759470	3	2	1	1	0	0	0	0	1	0	0	0	8171	1725	60	5	751	5	KDM4DL	11	94759470	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	22290595	94759470	40247046	103	103											
SLC6A12	6539	broad.mit.edu	37	chr12	301770	301770	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggtacacatagacgttgttGtacttgaggggggtgtactt	8	13	15	5	1	0	2	0	1	0	1	0	2	0	2	0	4	3	5	0	4	4	8			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:301770G>A	uc001qhz.2	-	16	2118	c.1575C>T	c.(1573-1575)TAC>TAT	p.Y525Y	SLC6A12_uc001qhx.2_Silent_p.Y182Y|SLC6A12_uc001qhy.2_Silent_p.Y81Y|SLC6A12_uc001qia.2_Silent_p.Y525Y|SLC6A12_uc001qib.2_Silent_p.Y525Y|SLC6A12_uc009zdh.1_Silent_p.Y525Y	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	525					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			AGACGTTGTTGTACTTGAGGG	0.572													41	110					0	0	0	0	A	301770	A	A	301770	2	1	1	1	0	0	0	0	0	0	0	1	14739	1372	48	4		4	SLC6A12	12	301770	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08		301770	133550125	104	104											
CHD4	1108	broad.mit.edu	37	chr12	6690898	6690898	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttttggggagggtgaccctGgctgggacatcttcttgttt	4	16	14	7	0	2	1	0	1	2	0	2	3	2	3	1	5	0	2	1	5	0	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:6690898G>A	uc001qpo.2	-	31	4762	c.4598C>T	c.(4597-4599)CCA>CTA	p.P1533L	CHD4_uc001qpn.2_Missense_Mutation_p.P1526L|CHD4_uc001qpp.2_Missense_Mutation_p.P1558L|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1533					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GGGTGACCCTGGCTGGGACAT	0.562													66	154					0	0	0	0	A	6690898	A	A	6690898	3	1	1	1	0	0	0	0	1	0	0	0	3342	1348	47	4	1180	4	CHD4	12	6690898	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	6389128	6690898	127160997	105	105											
FAM90A1	55138	broad.mit.edu	37	chr12	8376719	8376719	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcccttccttttccccaaaGttcggtggaaccagggctgc	6	12	9	14	1	0	0	0	0	0	0	4	1	3	1	5	3	2	2	5	3	2	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:8376719G>C	uc001qui.2	-	5	775	c.216C>G	c.(214-216)AAC>AAG	p.N72K	FAM90A1_uc001quh.2_Missense_Mutation_p.N72K	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	72							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		TTTCCCCAAAGTTCGGTGGAA	0.547													79	164					0	0	0	0	C	8376719	C	C	8376719	3	2	1	1	0	0	0	0	1	0	0	0	5682	1020	36	4	1190	4	FAM90A1	12	8376719	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	1685821	8376719	125475176	106	106											
PRB1	5542	broad.mit.edu	37	chr12	11506685	11506685	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgtgggggtggtccttgtgGctttcctggaggaggtgggg	2	13	21	5	0	0	0	0	0	0	0	2	2	2	2	2	9	0	1	2	9	0	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:11506685G>C	uc001qzw.1	-	3	389	c.352C>G	c.(352-354)CCA>GCA	p.P118A	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	179	7.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGTCCTTGTGGCTTTCCTGGA	0.612													64	737					0	0	0	0	C	11506685	C	C	11506685	3	2	1	1	0	0	0	0	1	0	0	0	12504	1203	42	4	647	4	PRB1	12	11506685	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	3129966	11506685	122345210	107	107											
MLL2	8085	broad.mit.edu	37	chr12	49420409	49420409	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acggatggcacaagcaaaatGgtagacattggggcaacgca	15	5	13	8	2	0	1	0	0	0	1	0	2	0	2	0	5	2	5	0	5	5	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:49420409G>A	uc001rta.3	-	48	15340	c.15340C>T	c.(15340-15342)CAT>TAT	p.H5114Y		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5114	RING-type 4; degenerate.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CAAGCAAAATGGTAGACATTG	0.557			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			35	90					0	0	0	0	A	49420409	A	A	49420409	3	1	1	1	0	0	0	0	1	0	0	0	9674	1348	47	4	1301	4	MLL2	12	49420409	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	37913724	49420409	84431486	108	108											
PRPF40B	25766	broad.mit.edu	37	chr12	50037938	50037938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtgagctggagaggcggcGgcggacactcctacagcagc	8	4	18	11	3	0	2	0	1	0	1	1	4	1	3	1	6	4	2	1	6	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:50037938G>A	uc001rur.1	+	25	2643	c.2579G>A	c.(2578-2580)CGG>CAG	p.R860Q	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001ruq.1_Missense_Mutation_p.R847Q|PRPF40B_uc001rus.1_Missense_Mutation_p.R802Q|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	860					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GAGAGGCGGCGGCGGACACTC	0.607											OREG0021798	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	62					0	0	0	0	A	50037938	A	A	50037938	3	1	1	1	0	0	0	0	1	0	0	0	12634	1116	39	1	2677	1	PRPF40B	12	50037938	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	617529	50037938	83813957	109	109											
GNPTAB	79158	broad.mit.edu	37	chr12	102151077	102151077	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcgatttcttcttctcccAtgatttcaaacctaattatc	11	16	3	11	1	4	1	1	1	3	0	6	2	4	1	2	0	2	0	2	0	4	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:102151077A>G	uc001tit.2	-	18	3526	c.3347T>C	c.(3346-3348)ATG>ACG	p.M1116T		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	1116					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						TTCTTCTCCCATGATTTCAAA	0.284													7	45					0	0	0	0	G	102151077	G	G	102151077	3	3	1	1	0	0	0	0	1	0	0	0	6582	217	8	5	439	5	GNPTAB	12	102151077	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	52113139	102151077	31700818	110	110											
DRAM1	55332	broad.mit.edu	37	chr12	102295157	102295157	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctgtttttaacttggtgtcTttagtgcttggattggtggg	4	19	13	5	0	1	0	0	0	1	0	1	1	1	1	1	4	2	2	1	4	2	8			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:102295157T>C	uc001tix.2	+	3	751	c.288T>C	c.(286-288)TCT>TCC	p.S96S	DRAM1_uc010svv.1_Silent_p.S96S	NM_018370	NP_060840	Q8N682	DRAM1_HUMAN	DNA-damage regulated autophagy modulator 1	96	Helical; (Potential).				apoptosis|autophagy	integral to membrane|lysosomal membrane				ovary(1)	1						ACTTGGTGTCTTTAGTGCTTG	0.408													23	85					0	0	0	0	C	102295157	C	C	102295157	2	2	1	1	0	0	0	0	0	0	0	1	4775	1596	56	5		5	DRAM1	12	102295157	Silent	SNP	T	TCGA-BA-4074-01A-01D-1434-08	144080	102295157	31556738	111	111											
RAD9B	144715	broad.mit.edu	37	chr12	110968353	110968353	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgcatgttctttggagcAgtttcttctgaccagcaaga	8	15	9	9	0	4	2	0	1	4	1	4	3	4	3	1	1	3	5	1	1	1	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:110968353A>G	uc001trf.3	+	11	1287	c.1149A>G	c.(1147-1149)GCA>GCG	p.A383A	RAD9B_uc001trg.3_Silent_p.A383A|RAD9B_uc010sya.1_Intron|RAD9B_uc001tre.3_Silent_p.A311A|RAD9B_uc001trd.3_Silent_p.A225A	NM_152442	NP_689655	Q6WBX8	RAD9B_HUMAN	RAD9 homolog B	380					cell cycle checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding			pancreas(1)|skin(1)	2						TCTTTGGAGCAGTTTCTTCTG	0.433													36	127					0	0	0	0	G	110968353	G	G	110968353	2	3	1	1	0	0	0	0	0	0	0	1	13061	175	7	5		5	RAD9B	12	110968353	Silent	SNP	A	TCGA-BA-4074-01A-01D-1434-08	8673196	110968353	22883542	112	112											
SFRS8	6433	broad.mit.edu	37	chr12	132237706	132237706	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attacagctactacatgctaCcggacggcacttactgcctg	10	10	8	13	2	0	0	0	0	0	0	0	1	0	1	2	2	8	3	2	2	5	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr12:132237706C>T	uc001uja.1	+	8	1260	c.1120C>T	c.(1120-1122)CCG>TCG	p.P374S	SFRS8_uc010tbn.1_Missense_Mutation_p.P374S|SFRS8_uc001ujb.1_Missense_Mutation_p.P167S|SFRS8_uc001uiz.1_Missense_Mutation_p.P248S	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	374					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		CTACATGCTACCGGACGGCAC	0.612													56	119					0	0	0	0	T	132237706	T	T	132237706	3	4	1	1	0	0	0	0	1	0	0	0	14248	507	18	4	1150	4	SFRS8	12	132237706	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	21269353	132237706	1614189	113	113											
ZMYM2	7750	broad.mit.edu	37	chr13	20656229	20656229	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacatttgagcaagaattgaAtaaaatactgcgaagctggc	17	9	9	6	1	0	3	0	2	0	1	0	4	0	3	0	1	5	2	0	1	8	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr13:20656229A>G	uc001umr.2	+	23	3825	c.3527A>G	c.(3526-3528)AAT>AGT	p.N1176S	ZMYM2_uc001ums.2_Missense_Mutation_p.N1176S|ZMYM2_uc001umt.2_Missense_Mutation_p.N1176S|ZMYM2_uc001umv.2_Missense_Mutation_p.N556S|ZMYM2_uc001umw.2_Missense_Mutation_p.N629S	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	1176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CAAGAATTGAATAAAATACTG	0.328													16	15					0	0	0	0	G	20656229	G	G	20656229	3	3	1	1	0	0	0	0	1	0	0	0	17767	101	4	5	3605	5	ZMYM2	13	20656229	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08		20656229	94513649	114	114											
KATNAL1	84056	broad.mit.edu	37	chr13	30801627	30801627	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcccacgggaaattagtagCagccaataccataaccattt	14	9	7	11	1	0	0	0	0	0	0	1	1	1	1	4	1	4	2	4	1	6	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr13:30801627C>T	uc001uss.2	-	9	1170	c.1069G>A	c.(1069-1071)GCT>ACT	p.A357T	KATNAL1_uc001ust.2_Missense_Mutation_p.A357T	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	357						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		AAATTAGTAGCAGCCAATACC	0.378													20	43					0	0	0	0	T	30801627	T	T	30801627	3	4	1	1	0	0	0	0	1	0	0	0	8024	710	25	4	415	4	KATNAL1	13	30801627	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	10145398	30801627	84368251	115	115											
KLHL1	57626	broad.mit.edu	37	chr13	70535475	70535475	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggacaaggtcccagagagcaTtggggtctatgccttccatt	9	10	12	10	0	1	1	0	0	1	1	3	3	3	2	3	4	2	1	3	4	2	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr13:70535475T>A	uc001vip.2	-	3	1576	c.782A>T	c.(781-783)AAT>ATT	p.N261I	KLHL1_uc010thm.1_Missense_Mutation_p.N200I	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	261	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CCAGAGAGCATTGGGGTCTAT	0.383													44	55					0	0	0	0	A	70535475	A	A	70535475	3	1	1	1	0	0	0	0	1	0	0	0	8404	1493	52	5	1500	5	KLHL1	13	70535475	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	39733848	70535475	44634403	116	116											
SUPT16H	11198	broad.mit.edu	37	chr14	21831284	21831284	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctttctgatgtgctcttcGcttctcttctgcagtcattt	3	21	6	11	1	6	1	1	1	5	0	8	1	6	1	0	0	2	3	0	0	0	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:21831284G>A	uc001wao.2	-	13	1759	c.1420C>T	c.(1420-1422)CGA>TGA	p.R474*		NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	474	Potential.				DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TGTGCTCTTCGCTTCTCTTCT	0.398													58	171					0	0	0	0	A	21831284	A	A	21831284	4	1	1	1	0	0	0	0	0	1	0	0	15462	1095	38	1	1779	1	SUPT16H	14	21831284	Nonsense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08		21831284	85518256	117	117											
MYH7	4625	broad.mit.edu	37	chr14	23884668	23884668	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccacttcagtctggagctgGgacaggtcagcatccatctt	8	11	10	12	0	4	0	2	0	2	0	6	2	6	2	2	3	2	2	2	3	0	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:23884668G>A	uc001wjx.2	-	36	5311	c.5205C>T	c.(5203-5205)TCC>TCT	p.S1735S		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1735	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCTGGAGCTGGGACAGGTCAG	0.557													46	125					0	0	0	0	A	23884668	A	A	23884668	2	1	1	1	0	0	0	0	0	0	0	1	10092	1219	43	4		4	MYH7	14	23884668	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08	2053384	23884668	83464872	118	118											
GPR137C	283554	broad.mit.edu	37	chr14	53098999	53098999	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacattagaaagtccatttaAttatggctgggataatcttt	13	16	7	5	0	1	1	0	0	1	1	2	2	2	2	1	2	1	1	1	2	6	7			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:53098999A>C	uc001wzu.3	+	4	839	c.839A>C	c.(838-840)AAT>ACT	p.N280T	GPR137C_uc001wzt.3_Missense_Mutation_p.N296T	NM_001099652	NP_001093122	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	280	Extracellular (Potential).					integral to membrane					0	Breast(41;0.0716)					AGTCCATTTAATTATGGCTGG	0.388													30	69					0	0	0	0	C	53098999	C	C	53098999	3	2	1	1	0	0	0	0	1	0	0	0	6685	101	4	5	853	5	GPR137C	14	53098999	Missense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	29214331	53098999	54250541	119	119											
PLEKHH1	57475	broad.mit.edu	37	chr14	68008608	68008608	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagaactcaaggtggaggcGccggccagcgtagactggca	10	4	16	11	3	1	2	1	0	0	2	1	3	1	3	2	5	2	3	2	5	3	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:68008608G>A	uc001xjl.1	+	2	166	c.24G>A	c.(22-24)GCG>GCA	p.A8A		NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	8						cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		AGGTGGAGGCGCCGGCCAGCG	0.537													3	10					0	0	0	0	A	68008608	A	A	68008608	2	1	1	1	0	0	0	0	0	0	0	1	12131	1074	38	1		1	PLEKHH1	14	68008608	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08	14909609	68008608	39340932	120	120											
ZFYVE26	23503	broad.mit.edu	37	chr14	68249583	68249583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acacttcagtgagctgaaggGcccgggaccaatctctggcc	9	7	12	13	1	2	2	1	2	1	0	3	3	2	3	3	3	1	1	3	3	2	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:68249583G>A	uc001xka.2	-	21	4425	c.4286C>T	c.(4285-4287)GCC>GTC	p.A1429V	ZFYVE26_uc010tsz.1_Intron|ZFYVE26_uc001xkc.3_Missense_Mutation_p.A1429V	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1429					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GAGCTGAAGGGCCCGGGACCA	0.532													80	226					0	0	0	0	A	68249583	A	A	68249583	3	1	1	1	0	0	0	0	1	0	0	0	17735	1203	42	4	3421	4	ZFYVE26	14	68249583	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	240975	68249583	39099957	121	121											
C14orf169	79697	broad.mit.edu	37	chr14	73957815	73957815	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cacagcgggtcggtcctggcCctgcccttgaggtccaggaa	6	7	14	14	2	0	1	0	1	0	0	3	2	2	2	4	5	2	0	4	5	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:73957815C>T	uc001xok.1	+	1	172	c.93C>T	c.(91-93)GCC>GCT	p.A31A	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	31					negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)		CGGTCCTGGCCCTGCCCTTGA	0.677													15	27					0	0	0	0	T	73957815	T	T	73957815	2	4	1	1	0	0	0	0	0	0	0	1	1764	610	22	4		4	C14orf169	14	73957815	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	5708232	73957815	33391725	122	122											
PNMA1	9240	broad.mit.edu	37	chr14	74179621	74179621	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgggcatccctagagctcTcaacgctcccaaacacctgc	9	8	7	17	1	2	1	1	0	2	1	5	1	4	1	3	1	4	3	3	1	3	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:74179621T>C	uc001xor.1	-	1	1508	c.722A>G	c.(721-723)GAG>GGG	p.E241G		NM_006029	NP_006020	Q8ND90	PNMA1_HUMAN	paraneoplastic antigen MA1	241					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		cctagagctctcaacgctccc	0													41	115					0	0	0	0	C	74179621	C	C	74179621	3	2	1	1	0	0	0	0	1	0	0	0	12208	1551	54	5	343	5	PNMA1	14	74179621	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	221806	74179621	33169919	123	123											
RPS6KA5	9252	broad.mit.edu	37	chr14	91338426	91338426	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcctaccatgcctaagctaCtgagtccgagaactggaaga	12	8	9	12	1	0	3	0	1	0	2	2	5	2	4	4	1	5	1	4	1	5	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr14:91338426C>T	uc001xys.2	-	17	2616	c.2401G>A	c.(2401-2403)GTA>ATA	p.V801I	RPS6KA5_uc010twi.1_Missense_Mutation_p.V722I	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	801				VA -> ELRHGRSDQ (in Ref. 3; AAC69577).	axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		GCCTAAGCTACTGAGTCCGAG	0.483													54	128					0	0	0	0	T	91338426	T	T	91338426	3	4	1	1	0	0	0	0	1	0	0	0	13719	565	20	4	11	4	RPS6KA5	14	91338426	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	17158805	91338426	16011114	124	124											
C15orf2	23742	broad.mit.edu	37	chr15	24922597	24922597	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggattcccctcctcctctttCcttcctgactcttcttccag	3	16	4	18	0	3	1	0	1	3	0	9	2	9	2	7	1	0	0	7	1	0	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr15:24922597C>T	uc001ywo.2	+	1	2057	c.1583C>T	c.(1582-1584)TCC>TTC	p.S528F		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	528	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTCCTCTTTCCTTCCTGACT	0.532													99	293					0	0	0	0	T	24922597	T	T	24922597	3	4	1	1	0	0	0	0	1	0	0	0	1790	855	30	2	1585	2	C15orf2	15	24922597	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08		24922597	77608795	125	125											
RASGRP1	10125	broad.mit.edu	37	chr15	38794593	38794594	+	Frame_Shift_Ins	INS	-	T	T																															cctgagaaatgtatccatccINStggtcgtgatcatagttctt																										TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr15:38794593_38794594insT	uc001zke.3	-	12	1635_1636	c.1457_1458insA	c.(1456-1458)CAGfs	p.Q486fs	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Frame_Shift_Ins_p.Q313fs|RASGRP1_uc010bbg.2_Frame_Shift_Ins_p.Q313fs|RASGRP1_uc001zkd.3_Frame_Shift_Ins_p.Q451fs	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	486	1 (Potential).|EF-hand 1.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TGTATCCATCCTGGTCGTGATC	0.391													---	---	---								T	38794594	T	T	38794593	7	5	1	1	0	1	1	0	0	0	0	0	13139	680	24	0	959	0	RASGRP1	15	38794593	Frame_Shift_Ins	INS	-	TCGA-BA-4074-01A-01D-1434-08	13871996	38794593	63736799	126	126											
MNS1	55329	broad.mit.edu	37	chr15	56748614	56748614	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttctcttacttgttgccTcatcttttcgtcctttagac	4	21	5	11	1	3	1	1	0	2	1	6	1	4	1	2	0	2	2	2	0	2	9			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr15:56748614T>C	uc002adr.2	-	3	496	c.331A>G	c.(331-333)AGG>GGG	p.R111G	MNS1_uc010bfo.2_5'UTR	NM_018365	NP_060835	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	111	Potential.|Glu-rich.				meiosis					ovary(1)	1				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		ACTTGTTGCCTCATCTTTTCG	0.333													3	95					0	0	0	0	C	56748614	C	C	56748614	3	2	1	1	0	0	0	0	1	0	0	0	9730	1550	54	5	1188	5	MNS1	15	56748614	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	17954021	56748614	45782778	127	127											
MAPK8IP3	23162	broad.mit.edu	37	chr16	1812698	1812698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcccgagagcacccatccGtccaggagaagaagaagtcg	12	4	12	13	4	0	4	0	0	0	4	4	6	3	4	4	1	1	1	4	1	3	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:1812698G>A	uc002cmk.2	+	15	1810	c.1690G>A	c.(1690-1692)GTC>ATC	p.V564I	MAPK8IP3_uc002cml.2_Missense_Mutation_p.V558I|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.V565I	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	564					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						GCACCCATCCGTCCAGGAGAA	0.662													81	165					0	0	0	0	A	1812698	A	A	1812698	3	1	1	1	0	0	0	0	1	0	0	0	9339	1145	40	1	1764	1	MAPK8IP3	16	1812698	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08		1812698	88542055	128	128											
CREBBP	1387	broad.mit.edu	37	chr16	3786099	3786099	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcctcttcttcttgttctaGttccttaatgctctcttcta	4	21	3	13	0	6	0	0	0	6	0	9	0	8	0	2	0	1	3	2	0	3	9			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:3786099G>C	uc002cvv.2	-	28	4870	c.4666C>G	c.(4666-4668)CTA>GTA	p.L1556V	CREBBP_uc002cvw.2_Missense_Mutation_p.L1518V	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1556	Poly-Glu.|Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TCTTGTTCTAGTTCCTTAATG	0.478			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				50	107					0	0	0	0	C	3786099	C	C	3786099	3	2	1	1	0	0	0	0	1	0	0	0	3876	1020	36	4	2678	4	CREBBP	16	3786099	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	1973401	3786099	86568654	129	129											
ANKS3	124401	broad.mit.edu	37	chr16	4747373	4747373	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccagggctcccgagagctCggggaggctcatggcctgca	6	6	15	14	2	1	1	1	0	0	1	4	3	3	2	3	5	2	4	3	5	0	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:4747373C>T	uc002cxj.1	-	16	2150	c.1855G>A	c.(1855-1857)GAG>AAG	p.E619K	ANKS3_uc010uxr.1_Missense_Mutation_p.E142K|ANKS3_uc002cxh.1_RNA|ANKS3_uc002cxi.1_Missense_Mutation_p.E546K|ANKS3_uc002cxk.2_Missense_Mutation_p.E490K|ANKS3_uc002cxl.2_Missense_Mutation_p.E446K|ANKS3_uc010uxs.1_Missense_Mutation_p.E546K	NM_133450	NP_597707	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain	619											0						CCCGAGAGCTCGGGGAGGCTC	0.657													48	119					0	0	0	0	T	4747373	T	T	4747373	3	4	1	1	0	0	0	0	1	0	0	0	690	893	31	1	123	1	ANKS3	16	4747373	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	961274	4747373	85607380	130	130											
SEPT12	124404	broad.mit.edu	37	chr16	4833975	4833975	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtacacgcagcagtgcacccGggtgtctgggatgtggcgct	6	8	16	11	3	1	0	0	0	1	0	1	1	1	1	1	3	3	5	1	3	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:4833975G>A	uc002cxq.2	-	5	610	c.469C>T	c.(469-471)CGG>TGG	p.R157W	SEPT12_uc002cxr.2_Intron|SEPT12_uc010bty.2_RNA	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	157					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						CAGTGCACCCGGGTGTCTGGG	0.637													49	133					0	0	0	0	A	4833975	A	A	4833975	3	1	1	1	0	0	0	0	1	0	0	0	14127	1115	39	1	631	1	SEPT12	16	4833975	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	86602	4833975	85520778	131	131											
ARHGAP17	55114	broad.mit.edu	37	chr16	24971270	24971270	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atactccccttctttggccaTaaagttgtacatgtctgctg	8	15	7	11	0	2	0	0	0	2	0	3	0	3	0	3	1	3	3	3	1	4	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:24971270T>G	uc002dnb.2	-	8	697	c.604A>C	c.(604-606)ATG>CTG	p.M202L	ARHGAP17_uc002dna.2_5'Flank|ARHGAP17_uc002dnc.2_Missense_Mutation_p.M202L|ARHGAP17_uc010vcf.1_Missense_Mutation_p.M23L|ARHGAP17_uc002dnf.2_Missense_Mutation_p.M110L|ARHGAP17_uc002dng.1_Missense_Mutation_p.M202L	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	202	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		TCTTTGGCCATAAAGTTGTAC	0.363													35	106					0	0	0	0	G	24971270	G	G	24971270	3	3	1	1	0	0	0	0	1	0	0	0	867	1406	49	5	2093	5	ARHGAP17	16	24971270	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	20137295	24971270	65383483	132	132											
CCL22	6367	broad.mit.edu	37	chr16	57392508	57392508	+	5'Flank	DEL	G	-	-																															agaggcgaggacagagttgaGggggggtcccctctgagtgg																								rs41411344	byFrequency	TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:57392508delG	uc002elh.2	+							NM_002990	NP_002981	O00626	CCL22_HUMAN	small inducible cytokine A22 precursor						cell-cell signaling|chemotaxis|immune response|inflammatory response|response to virus|signal transduction	extracellular space	chemokine activity				0						ACAGAGTTGAGGGGGGGTCCC	0.473													---	---	---								-	57392508	-	-	57392508	6	5	1	0	1	1	0	1	0	0	0	0	2907	1015	35	0		0	CCL22	16	57392508	5'Flank	DEL	G	TCGA-BA-4074-01A-01D-1434-08	32421238	57392508	32962245	133	133											
E2F4	1874	broad.mit.edu	37	chr16	67228755	67228755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtttctacacctccacCtctgcccaagcctgccctag	6	11	6	18	0	2	0	0	0	2	0	3	0	3	0	6	0	5	2	6	0	3	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:67228755C>T	uc002erz.2	+	6	743	c.680C>T	c.(679-681)CCT>CTT	p.P227L		NM_001950	NP_001941	Q16254	E2F4_HUMAN	E2F transcription factor 4	227					G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		ACACCTCCACCTCTGCCCAAG	0.597													48	95					0	0	0	0	T	67228755	T	T	67228755	3	4	1	1	0	0	0	0	1	0	0	0	4891	681	24	4	702	4	E2F4	16	67228755	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	9836247	67228755	23125998	134	134											
CDH1	999	broad.mit.edu	37	chr16	68853291	68853291	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gattttgagcacgtgaagaaCagcacgtacacagccctaat	14	8	9	10	2	0	3	0	2	0	1	0	4	0	3	1	0	5	3	1	0	4	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:68853291C>A	uc002ewg.1	+	11	1798	c.1674C>A	c.(1672-1674)AAC>AAA	p.N558K	CDH1_uc010vlj.1_Intron|CDH1_uc010cfg.1_Missense_Mutation_p.N497K	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	558	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		ACGTGAAGAACAGCACGTACA	0.537			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				4	101					0.00909568	0.00918897	1	0	A	68853291	A	A	68853291	3	1	1	1	0	0	0	0	1	0	0	0	3110	477	17	4	1716	4	CDH1	16	68853291	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	1624536	68853291	21501462	135	135											
ZNF778	197320	broad.mit.edu	37	chr16	89293174	89293174	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcagtgaacactcaggcCtcagcacacacgtgagaact	12	8	8	13	1	3	2	3	2	0	1	3	3	3	2	1	1	3	1	1	1	2	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr16:89293174C>T	uc002fmv.2	+	6	733	c.394C>T	c.(394-396)CTC>TTC	p.L132F	ZNF778_uc010vpf.1_Intron|ZNF778_uc002fmw.1_Missense_Mutation_p.L90F|ZNF778_uc010vpg.1_5'UTR	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	132	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)		ACACTCAGGCCTCAGCACACA	0.463													15	37					0	0	0	0	T	89293174	T	T	89293174	3	4	1	1	0	0	0	0	1	0	0	0	18218	681	24	4	412	4	ZNF778	16	89293174	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	20439883	89293174	1061579	136	136											
NUP88	4927	broad.mit.edu	37	chr17	5312067	5312067	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttacctgtgtaacagactGatgtatgtcaggaaagtctc	12	12	9	8	0	2	2	1	1	1	1	3	3	2	3	1	1	2	2	1	1	4	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:5312067G>A	uc002gbo.1	-	5	869	c.843C>T	c.(841-843)ATC>ATT	p.I281I	NUP88_uc010vsx.1_Silent_p.I281I|NUP88_uc010cle.1_Silent_p.I280I|NUP88_uc010vsy.1_Silent_p.I281I	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	281					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						GTAACAGACTGATGTATGTCA	0.438													86	64					0	0	0	0	A	5312067	A	A	5312067	2	1	1	1	0	0	0	0	0	0	0	1	10825	1280	45	2		2	NUP88	17	5312067	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08		5312067	75883143	137	137											
PHF23	79142	broad.mit.edu	37	chr17	7139299	7139299	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccgcatctcgccttcactgGagctggcatctccatcttgg	5	11	9	16	2	4	0	1	0	3	0	6	1	4	1	3	3	1	3	3	3	0	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:7139299G>A	uc002gfa.2	-	4	1174	c.947C>T	c.(946-948)TCC>TTC	p.S316F	DVL2_uc002gez.1_5'Flank|DVL2_uc010vtr.1_5'Flank|DVL2_uc010clz.1_5'Flank|PHF23_uc010vtt.1_Missense_Mutation_p.S249F|PHF23_uc010cma.2_Missense_Mutation_p.S186F	NM_024297	NP_077273	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	316							zinc ion binding				0						GCCTTCACTGGAGCTGGCATC	0.587													416	274					0	0	0	0	A	7139299	A	A	7139299	3	1	1	1	0	0	0	0	1	0	0	0	11890	1174	41	2	272	2	PHF23	17	7139299	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	1827232	7139299	74055911	138	138											
TNFSF12-TNFSF13	407977	broad.mit.edu	37	chr17	7451455	7451456	+	5'Flank	INS	-	C	C																															cgcgcccagccaattttggtINSccttccttccttccttcctt																										TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:7451455_7451456insC	uc002ghi.1	+						TNFSF12_uc002ghg.2_5'Flank|TNFSF12_uc002ghh.2_5'Flank	NM_172089	NP_742086	Q8IZK7	Q8IZK7_HUMAN	TNFSF12-TNFSF13 protein						immune response	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding				0		Prostate(122;0.157)				ccAATTTTGGtccttccttcct	0.01													---	---	---								C	7451456	C	C	7451455	6	5	1	0	1	1	1	0	0	0	0	0	16370	1682	58	0		0	TNFSF12-TNFSF13	17	7451455	5'Flank	INS	-	TCGA-BA-4074-01A-01D-1434-08	312156	7451455	73743755	139	139											
TP53	7157	broad.mit.edu	37	chr17	7577507	7577507	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtggctcctgacctggagtcTtccagtgtgatgatggtgag	6	12	15	8	0	1	4	0	4	1	0	3	5	3	5	3	3	0	1	3	3	0	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:7577507T>A	uc002gim.2	-	7	968	c.774A>T	c.(772-774)GAA>GAT	p.E258D	TP53_uc002gig.1_Missense_Mutation_p.E258D|TP53_uc002gih.2_Missense_Mutation_p.E258D|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E126D|TP53_uc010cng.1_Missense_Mutation_p.E126D|TP53_uc002gii.1_Missense_Mutation_p.E126D|TP53_uc010cnh.1_Missense_Mutation_p.E258D|TP53_uc010cni.1_Missense_Mutation_p.E258D|TP53_uc002gij.2_Missense_Mutation_p.E258D|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.E165D|TP53_uc002gio.2_Missense_Mutation_p.E126D	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	258	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> Q (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E258K(37)|p.E258*(12)|p.E258Q(8)|p.E258D(8)|p.0?(7)|p.E258G(7)|p.E258V(5)|p.E258A(5)|p.D259fs*5(1)|p.?(1)|p.E258fs*85(1)|p.E258>XX(1)|p.E258fs*71(1)|p.D259fs*86(1)|p.E258fs*2(1)|p.E258_S260delEDS(1)|p.E258del(1)|p.E258L(1)|p.E258fs*87(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACCTGGAGTCTTCCAGTGTGA	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	31					0	0	0	0	A	7577507	A	A	7577507	3	1	1	1	0	0	0	0	1	0	0	0	16448	1606	56	5	516	5	TP53	17	7577507	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	126052	7577507	73617703	140	140											
CNTROB	116840	broad.mit.edu	37	chr17	7836476	7836476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcatcagaaccccctgggCtcaaccaagtgtcgtctgaa	11	9	8	13	1	4	2	3	1	1	1	5	2	4	2	3	1	2	1	3	1	4	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:7836476C>T	uc002gjq.2	+	2	998	c.79C>T	c.(79-81)CTC>TTC	p.L27F	TRAPPC1_uc002gjo.1_5'Flank|CNTROB_uc002gjp.2_Missense_Mutation_p.L27F|CNTROB_uc002gjr.2_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	27					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				ACCCCCTGGGCTCAACCAAGT	0.597													163	127					0	0	0	0	T	7836476	T	T	7836476	3	4	1	1	0	0	0	0	1	0	0	0	3666	797	28	4	81	4	CNTROB	17	7836476	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	258969	7836476	73358734	141	141											
STX8	9482	broad.mit.edu	37	chr17	9395196	9395196	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgccccatttgtttttggCgacttatgatagaggaaagg	9	13	11	8	1	0	2	0	1	0	1	0	4	0	3	3	3	1	1	3	3	3	5	rs143935601		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:9395196C>T	uc002glx.2	-	6	641	c.491G>A	c.(490-492)CGC>CAC	p.R164H		NM_004853	NP_004844	Q9UNK0	STX8_HUMAN	syntaxin 8	164	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1						TTGTTTTTGGCGACTTATGAT	0.363													109	117					0	0	0	0	T	9395196	T	T	9395196	3	4	1	1	0	0	0	0	1	0	0	0	15417	768	27	1	231	1	STX8	17	9395196	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	1558720	9395196	71800014	142	142											
MYH4	4622	broad.mit.edu	37	chr17	10356164	10356164	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tatccattgtggattcttggGccaattttaggtcaccctcc	7	15	8	11	0	2	0	1	0	1	0	4	1	4	1	4	3	0	0	4	3	3	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:10356164G>A	uc002gmn.2	-	25	3308	c.3197C>T	c.(3196-3198)GCC>GTC	p.A1066V	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1066	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GGATTCTTGGGCCAATTTTAG	0.363													143	145					0	0	0	0	A	10356164	A	A	10356164	3	1	1	1	0	0	0	0	1	0	0	0	10090	1203	42	4	2686	4	MYH4	17	10356164	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	960968	10356164	70839046	143	143											
MPP2	4355	broad.mit.edu	37	chr17	41958711	41958711	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcactgcccccttcgacatGgcatgcctaaaacggacatg	11	7	9	14	2	0	0	0	0	0	0	1	2	0	1	3	2	4	2	3	2	2	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:41958711G>A	uc010wip.1	-	8	1012	c.955C>T	c.(955-957)CAT>TAT	p.H319Y	MPP2_uc002ien.1_Missense_Mutation_p.H291Y|MPP2_uc010wim.1_Missense_Mutation_p.H263Y|MPP2_uc002ieo.1_Missense_Mutation_p.H274Y|MPP2_uc010win.1_Missense_Mutation_p.H135Y|MPP2_uc010wio.1_Missense_Mutation_p.H263Y	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	298	SH3.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CCTTCGACATGGCATGCCTAA	0.597											OREG0024443	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	111	59					0	0	0	0	A	41958711	A	A	41958711	3	1	1	1	0	0	0	0	1	0	0	0	9787	1348	47	4	862	4	MPP2	17	41958711	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	31602547	41958711	39236499	144	144											
ACSF2	80221	broad.mit.edu	37	chr17	48540530	48540531	+	Frame_Shift_Ins	INS	-	C	C																															tgtcaggggacaacaggcagINSccccaagggggccaccctct																										TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:48540530_48540531insC	uc002iqu.2	+	7	910_911	c.806_807insC	c.(805-807)AGCfs	p.S269fs	ACSF2_uc010wml.1_Frame_Shift_Ins_p.S226fs|ACSF2_uc010wmm.1_Frame_Shift_Ins_p.S294fs|ACSF2_uc010wmn.1_Frame_Shift_Ins_p.S256fs|ACSF2_uc010wmo.1_Frame_Shift_Ins_p.S109fs	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2 precursor	269	ATP (By similarity).				fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			ACAACAGGCAGCCCCAAGGGGG	0.53													---	---	---								C	48540531	C	C	48540530	7	5	1	1	0	1	1	0	0	0	0	0	175	971	34	0	832	0	ACSF2	17	48540530	Frame_Shift_Ins	INS	-	TCGA-BA-4074-01A-01D-1434-08	6581819	48540530	32654680	145	145											
FTSJ3	117246	broad.mit.edu	37	chr17	61903471	61903471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtcaccacattggggagaGgcttgattggaaccaggtcc	10	8	14	9	0	1	2	1	1	0	1	2	5	2	3	3	5	1	1	3	5	1	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:61903471G>A	uc002jbz.2	-	4	323	c.245C>T	c.(244-246)CCT>CTT	p.P82L	FTSJ3_uc002jca.2_Missense_Mutation_p.P82L|PSMC5_uc002jcb.2_5'Flank|PSMC5_uc010ddy.2_5'Flank|PSMC5_uc010ddz.2_5'Flank|PSMC5_uc002jcc.2_5'Flank|PSMC5_uc002jcd.2_5'Flank	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	82					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						ATTGGGGAGAGGCTTGATTGG	0.468													130	98					0	0	0	0	A	61903471	A	A	61903471	3	1	1	1	0	0	0	0	1	0	0	0	6123	1000	35	4	2366	4	FTSJ3	17	61903471	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	13362941	61903471	19291739	146	146											
METRNL	284207	broad.mit.edu	37	chr17	81043036	81043036	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagaactgagactgctggtAccagacggggacggcaggcc	10	4	17	10	2	0	3	0	1	0	3	0	6	0	4	2	6	3	3	2	6	2	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr17:81043036A>G	uc002kgh.2	+	2	518	c.393A>G	c.(391-393)GTA>GTG	p.V131V	METRNL_uc002kgi.2_Silent_p.V49V	NM_001004431	NP_001004431	Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation	131						extracellular region					0	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			GACTGCTGGTACCAGACGGGG	0.632													72	42					0	0	0	0	G	81043036	G	G	81043036	2	3	1	1	0	0	0	0	0	0	0	1	9542	378	14	5		5	METRNL	17	81043036	Silent	SNP	A	TCGA-BA-4074-01A-01D-1434-08	19139565	81043036	152174	147	147											
CDH2	1000	broad.mit.edu	37	chr18	25585828	25585828	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttaccaggctttgatccctCaggaactgtcccattccaaa	10	11	6	14	0	1	1	1	1	0	0	4	2	4	2	4	2	2	1	4	2	3	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr18:25585828C>G	uc002kwg.2	-	6	1291	c.832G>C	c.(832-834)GAG>CAG	p.E278Q	CDH2_uc010xbn.1_Missense_Mutation_p.E247Q	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	278	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TTTGATCCCTCAGGAACTGTC	0.388													48	116					0	0	0	0	G	25585828	G	G	25585828	3	3	1	1	0	0	0	0	1	0	0	0	3120	835	29	2	1932	2	CDH2	18	25585828	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08		25585828	52491420	148	148											
PIGN	23556	broad.mit.edu	37	chr18	59777191	59777191	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctacaaaactacaaggcaGgagatggcttggtttctgaa	14	9	11	7	0	1	2	0	1	1	1	1	3	1	2	0	4	4	4	0	4	6	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr18:59777191G>A	uc002lii.3	-	18	1898	c.1450C>T	c.(1450-1452)CTG>TTG	p.L484L	PIGN_uc002lij.3_Silent_p.L484L	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	484	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				CTACAAGGCAGGAGATGGCTT	0.343													3	66					0	0	0	0	A	59777191	A	A	59777191	2	1	1	1	0	0	0	0	0	0	0	1	11948	991	35	4		4	PIGN	18	59777191	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08	34191363	59777191	18300057	149	149											
CDH19	28513	broad.mit.edu	37	chr18	64239355	64239355	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcactggctgcttgactttCtttgtttgagagttttctgt	4	19	10	8	1	2	2	0	2	2	1	2	3	2	2	0	1	1	5	0	1	0	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr18:64239355C>G	uc002lkc.1	-	2	225	c.87G>C	c.(85-87)AAG>AAC	p.K29N	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.K29N|CDH19_uc002lkd.2_Missense_Mutation_p.K29N	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	29					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				GCTTGACTTTCTTTGTTTGAG	0.428													19	39					0	0	0	0	G	64239355	G	G	64239355	3	3	1	1	0	0	0	0	1	0	0	0	3119	912	32	2	2275	2	CDH19	18	64239355	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	4462164	64239355	13837893	150	150											
NETO1	81832	broad.mit.edu	37	chr18	70423379	70423379	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaatgtgttgccttcacaaGgagctaaaaagaagaagaac	18	7	10	6	0	1	4	1	0	0	4	1	5	1	5	1	1	3	2	1	1	8	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr18:70423379G>T	uc002lkw.2	-	8	1156	c.872C>A	c.(871-873)CCT>CAT	p.P291H	NETO1_uc002lkx.1_Missense_Mutation_p.P290H|NETO1_uc002lky.1_Missense_Mutation_p.P291H	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	291	LDL-receptor class A.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GCCTTCACAAGGAGCTAAAAA	0.333													29	50					4.87955e-14	5.19607e-14	1	0	T	70423379	T	T	70423379	3	4	1	1	0	0	0	0	1	0	0	0	10393	1000	35	4	741	4	NETO1	18	70423379	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	6184024	70423379	7653869	151	151											
ZNF236	7776	broad.mit.edu	37	chr18	74631933	74631933	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagctgagggacaagcaggCggagctgcaggacgagccca	11	3	17	10	2	0	2	0	2	0	0	0	6	0	5	1	4	5	4	1	4	1	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr18:74631933C>T	uc002lmi.2	+	20	3668	c.3470C>T	c.(3469-3471)GCG>GTG	p.A1157V	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1157					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GACAAGCAGGCGGAGCTGCAG	0.627													13	24					0	0	0	0	T	74631933	T	T	74631933	3	4	1	1	0	0	0	0	1	0	0	0	17856	768	27	1	3548	1	ZNF236	18	74631933	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	4208554	74631933	3445315	152	152											
TBXA2R	6915	broad.mit.edu	37	chr19	3600302	3600302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggccgaagaagatcatgaCgacgcccatgaagcgacaga	15	3	12	11	4	1	5	1	2	0	3	1	8	1	5	2	1	1	0	2	1	3	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:3600302C>T	uc002lyg.1	-	2	545	c.331G>A	c.(331-333)GTC>ATC	p.V111I	TBXA2R_uc002lye.1_Missense_Mutation_p.V111I	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	111	Helical; Name=3; (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	AAGATCATGACGACGCCCATG	0.692													13	23					0	0	0	0	T	3600302	T	T	3600302	3	4	1	1	0	0	0	0	1	0	0	0	15729	536	19	1	953	1	TBXA2R	19	3600302	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08		3600302	55528681	153	153											
ACSBG2	81616	broad.mit.edu	37	chr19	6187796	6187796	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaagccatgaacaatgcaCagaggattgaaaagtgggtc	16	6	13	6	0	0	3	0	2	0	1	1	5	0	5	1	3	3	1	1	3	5	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:6187796C>T	uc002mef.1	+	13	2094	c.1867C>T	c.(1867-1869)CAG>TAG	p.Q623*	ACSBG2_uc002mee.1_Nonsense_Mutation_p.Q436*|ACSBG2_uc002meg.1_Nonsense_Mutation_p.Q623*|ACSBG2_uc002meh.1_Nonsense_Mutation_p.Q623*|ACSBG2_uc002mei.1_Nonsense_Mutation_p.Q573*|ACSBG2_uc010xiz.1_Nonsense_Mutation_p.Q595*	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	623					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						GAACAATGCACAGAGGATTGA	0.507													54	159					0	0	0	0	T	6187796	T	T	6187796	4	4	1	1	0	0	0	0	0	1	0	0	174	479	17	4	1913	4	ACSBG2	19	6187796	Nonsense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	2587494	6187796	52941187	154	154											
ZNF266	10781	broad.mit.edu	37	chr19	9524051	9524051	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttacattcatagggtttcTctccagtgtgagttcgttca	7	16	8	10	1	3	1	2	1	1	0	6	1	4	1	2	1	1	3	2	1	2	6			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:9524051T>C	uc002mll.2	-	4	1816	c.1550A>G	c.(1549-1551)GAG>GGG	p.E517G	ZNF266_uc002mlm.2_Missense_Mutation_p.E517G|ZNF266_uc002mln.2_Missense_Mutation_p.E517G|ZNF266_uc002mlo.2_Missense_Mutation_p.E517G|ZNF266_uc010dwp.2_Missense_Mutation_p.E517G|ZNF266_uc010dwq.2_Missense_Mutation_p.E517G	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	517					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATAGGGTTTCTCTCCAGTGTG	0.438													47	116					0	0	0	0	C	9524051	C	C	9524051	3	2	1	1	0	0	0	0	1	0	0	0	17872	1551	54	5	103	5	ZNF266	19	9524051	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	3336255	9524051	49604932	155	155											
PODNL1	79883	broad.mit.edu	37	chr19	14044707	14044707	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtacctgaaggtggtggcatCcaggccactgtctgtcagct	7	10	13	11	0	2	1	1	1	1	0	3	1	3	1	3	4	2	3	3	4	2	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:14044707C>G	uc002mxr.2	-	7	1046	c.772G>C	c.(772-774)GAT>CAT	p.D258H	PODNL1_uc010xni.1_Missense_Mutation_p.D176H|PODNL1_uc010xnj.1_Missense_Mutation_p.D256H|PODNL1_uc002mxs.2_Missense_Mutation_p.D167H	NM_024825	NP_079101	Q6PEZ8	PONL1_HUMAN	podocan-like 1 isoform 1	258	Leu-rich.|LRR 8.					proteinaceous extracellular matrix				central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(19;5.26e-23)			GTGGTGGCATCCAGGCCACTG	0.612													3	17					0	0	0	0	G	14044707	G	G	14044707	3	3	1	1	0	0	0	0	1	0	0	0	12234	855	30	2	774	2	PODNL1	19	14044707	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	4520656	14044707	45084276	156	156											
ZNF676	163223	broad.mit.edu	37	chr19	22363783	22363783	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggtttctctccagtatgaaTtatcttatgtttagtaagga	10	17	9	5	0	2	1	0	1	2	0	4	2	3	2	1	2	0	4	1	2	6	7			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:22363783T>C	uc002nqs.1	-	3	1054	c.736A>G	c.(736-738)ATT>GTT	p.I246V		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	246	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CCAGTATGAATTATCTTATGT	0.358													17	194					0	0	0	0	C	22363783	C	C	22363783	3	2	1	1	0	0	0	0	1	0	0	0	18150	1493	52	5	1034	5	ZNF676	19	22363783	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	8319076	22363783	36765200	157	157											
CYP2A13	1553	broad.mit.edu	37	chr19	41594389	41594389	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgccaccatgctggcctcaGggctgcttctggtgaccttg	4	11	12	14	0	2	1	1	1	1	0	2	1	2	1	4	3	3	3	4	3	0	2	rs71579358		TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:41594389G>A	uc002opt.2	+	1	22	c.13G>A	c.(13-15)GGG>AGG	p.G5R		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	5					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding	p.G5E(1)		ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	GCTGGCCTCAGGGCTGCTTCT	0.557													17	52					0	0	0	0	A	41594389	A	A	41594389	3	1	1	1	0	0	0	0	1	0	0	0	4178	1000	35	4	15	4	CYP2A13	19	41594389	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	19230606	41594389	17534594	158	158											
CCDC9	26093	broad.mit.edu	37	chr19	47763905	47763905	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggcccccaggggccagcAaggggggccggactcctcca	6	3	15	17	2	0	0	0	0	0	0	3	1	2	1	6	7	1	1	6	7	1	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:47763905A>T	uc010xym.1	+	5	478	c.271A>T	c.(271-273)AAG>TAG	p.K91*		NM_015603	NP_056418	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	91	Gly-rich.										0		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		AGGGGCCAGCAAGGGGGGCCG	0.706													28	96					0	0	0	0	T	47763905	T	T	47763905	4	4	1	1	0	0	0	0	0	1	0	0	2880	131	5	5	285	5	CCDC9	19	47763905	Nonsense_Mutation	SNP	A	TCGA-BA-4074-01A-01D-1434-08	6169516	47763905	11365078	159	159											
MYH14	79784	broad.mit.edu	37	chr19	50785002	50785002	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggctggagcggggccgccGccggctgcagcaggagctgg	4	4	20	13	5	0	0	0	0	0	0	1	2	0	2	3	7	4	5	3	7	0	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:50785002G>A	uc002prr.1	+	31	4366	c.4319G>A	c.(4318-4320)CGC>CAC	p.R1440H	MYH14_uc010enu.1_Missense_Mutation_p.R1481H|MYH14_uc002prq.1_Missense_Mutation_p.R1448H|MYH14_uc010ycb.1_Intron	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1440	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CGGGGCCGCCGCCGGCTGCAG	0.701													5	15					0	0	0	0	A	50785002	A	A	50785002	3	1	1	1	0	0	0	0	1	0	0	0	10086	1087	38	1	4568	1	MYH14	19	50785002	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	3021097	50785002	8343981	160	160											
C19orf75	284369	broad.mit.edu	37	chr19	51768727	51768727	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtgcagtggtggatgggagGagtccccgtgggtgtggatg	5	10	21	5	1	0	0	0	0	0	0	1	4	1	4	2	6	1	1	2	6	0	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:51768727G>A	uc002pwb.1	+	3	509	c.128G>A	c.(127-129)GGA>GAA	p.G43E	C19orf75_uc010eov.1_Intron|C19orf75_uc010ycw.1_Intron	NM_173635	NP_775906	Q8N7X8	CS075_HUMAN	hypothetical protein LOC284369	43						integral to membrane				ovary(1)|pancreas(1)	2						TGGATGGGAGGAGTCCCCGTG	0.577													46	85					0	0	0	0	A	51768727	A	A	51768727	3	1	1	1	0	0	0	0	1	0	0	0	1958	1174	41	2	134	2	C19orf75	19	51768727	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	983725	51768727	7360256	161	161											
ZNF578	147660	broad.mit.edu	37	chr19	53015012	53015012	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcttacaaatgtgaagaaTgtgacagagttttcagtcag	15	12	9	5	0	3	4	2	2	1	2	3	4	3	4	0	0	1	1	0	0	5	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:53015012T>G	uc002pzp.3	+	6	1622	c.1378T>G	c.(1378-1380)TGT>GGT	p.C460G		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	235	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ATGTGAAGAATGTGACAGAGT	0.378													24	77					0	0	0	0	G	53015012	G	G	53015012	3	3	1	1	0	0	0	0	1	0	0	0	18077	1464	51	5	1388	5	ZNF578	19	53015012	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	1246285	53015012	6113971	162	162											
NLRP12	91662	broad.mit.edu	37	chr19	54327177	54327177	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctctgtcctctctcccacagGtccttcctgtttatccgctc	3	15	5	18	1	2	0	0	0	2	0	9	0	7	0	5	1	0	2	5	1	1	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:54327177G>A	uc002qch.3	-	1	472	c.252C>T	c.(250-252)GAC>GAT	p.D84D	NLRP12_uc002qci.3_Silent_p.D84D|NLRP12_uc002qcj.3_Silent_p.D84D|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.D84D	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	84	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TCTCCCACAGGTCCTTCCTGT	0.532													94	216					0	0	0	0	A	54327177	A	A	54327177	2	1	1	1	0	0	0	0	0	0	0	1	10528	1252	44	4		4	NLRP12	19	54327177	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08	1312165	54327177	4801806	163	163											
LAIR2	3904	broad.mit.edu	37	chr19	55020273	55020273	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcccggactccccggaCacagagcccggctcctcagc	7	3	13	18	3	1	1	1	0	0	1	3	4	3	4	5	5	2	1	5	5	0	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:55020273C>A	uc002qgc.2	+	4	515	c.393C>A	c.(391-393)GAC>GAA	p.D131E	LAIR2_uc002qgd.2_Intron|LAIR2_uc010erl.2_Missense_Mutation_p.T100K	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like	131						extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		ACTCCCCGGACACAGAGCCCG	0.632													20	53					1.42536e-11	1.50965e-11	1	0	A	55020273	A	A	55020273	3	1	1	1	0	0	0	0	1	0	0	0	8643	477	17	4	407	4	LAIR2	19	55020273	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	693096	55020273	4108710	164	164											
FIZ1	84922	broad.mit.edu	37	chr19	56104586	56104586	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgtgccgctccagcagcgCgggcgcgttgaagtcgcgct	4	8	15	14	7	0	1	0	1	0	0	2	1	1	1	2	1	3	4	2	1	1	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:56104586C>A	uc002qli.3	-	3	811	c.721G>T	c.(721-723)GCG>TCG	p.A241S	FIZ1_uc002qlj.3_Missense_Mutation_p.A241S	NM_032836	NP_116225	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	241	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		TCCAGCAGCGCGGGCGCGTTG	0.582													8	10					1.12685e-05	1.16225e-05	1	0	A	56104586	A	A	56104586	3	1	1	1	0	0	0	0	1	0	0	0	5932	768	27	3	773	3	FIZ1	19	56104586	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08	1084313	56104586	3024397	165	165											
NLRP13	126204	broad.mit.edu	37	chr19	56422072	56422072	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcaaatgctgttccatgcGtgcatcctggaatcaaactt	11	11	9	10	1	1	0	1	0	0	0	3	2	3	1	2	1	5	4	2	1	3	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr19:56422072G>A	uc010ygg.1	-	6	2164	c.2139C>T	c.(2137-2139)CAC>CAT	p.H713H		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	713							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TGTTCCATGCGTGCATCCTGG	0.463													44	129					0	0	0	0	A	56422072	A	A	56422072	2	1	1	1	0	0	0	0	0	0	0	1	10529	1136	40	1		1	NLRP13	19	56422072	Silent	SNP	G	TCGA-BA-4074-01A-01D-1434-08	317486	56422072	2706911	166	166											
TNFRSF6B	8771	broad.mit.edu	37	chr20	62329691	62329691	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctttccaggacatctccatCaagaggctgcagcggctgct	8	9	11	13	1	2	1	1	0	1	1	4	2	3	2	2	3	3	5	2	3	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr20:62329691C>G	uc002yfy.2	+	7	1112	c.678C>G	c.(676-678)ATC>ATG	p.I226M	RTEL1_uc002yfw.2_RNA|TNFRSF6B_uc002yfz.2_Missense_Mutation_p.I226M	NM_032945	NP_116563	O95407	TNF6B_HUMAN	tumor necrosis factor receptor superfamily,	226					anti-apoptosis|apoptosis	extracellular region|soluble fraction	protein binding|receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.66e-12)|all_epithelial(29;2.56e-13)|Lung NSC(23;1.06e-08)|all_lung(23;3.34e-08)		Epithelial(9;1.78e-08)|all cancers(9;7.89e-08)|OV - Ovarian serous cystadenocarcinoma(5;0.00504)			ACATCTCCATCAAGAGGCTGC	0.672													11	43					0	0	0	0	G	62329691	G	G	62329691	3	3	1	1	0	0	0	0	1	0	0	0	16364	816	29	2	688	2	TNFRSF6B	20	62329691	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08		62329691	695829	167	167											
TRPM2	7226	broad.mit.edu	37	chr21	45837865	45837865	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatttggaagttccagcgcCatgacctgatcgaggagtac	11	9	12	9	2	0	3	0	2	0	1	2	6	1	5	3	2	2	2	3	2	2	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr21:45837865C>T	uc002zet.1	+	22	3415	c.3202C>T	c.(3202-3204)CAT>TAT	p.H1068Y	TRPM2_uc002zeu.1_Missense_Mutation_p.H1068Y|TRPM2_uc002zew.1_Missense_Mutation_p.H1068Y|TRPM2_uc010gpt.1_Missense_Mutation_p.H1068Y|TRPM2_uc002zex.1_Missense_Mutation_p.H854Y|TRPM2_uc002zey.1_Missense_Mutation_p.H581Y|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1068	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTTCCAGCGCCATGACCTGAT	0.488													34	77					0	0	0	0	T	45837865	T	T	45837865	3	4	1	1	0	0	0	0	1	0	0	0	16653	594	21	4	3284	4	TRPM2	21	45837865	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08		45837865	2292030	168	168											
KRTAP10-10	353333	broad.mit.edu	37	chr21	46057446	46057446	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctgtgccccagcccccagcTtgaccctggtctgcacccca	5	7	9	20	0	1	1	0	1	1	0	1	1	1	1	7	1	4	3	7	1	0	1	rs444891	byFrequency	TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr21:46057446T>C	uc002zfq.2	+	1	174	c.112T>C	c.(112-114)TTG>CTG	p.L38L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	38	15 X 5 AA repeats of C-C-X(3).					keratin filament					0						AGCCCCCAGCTTGACCCTGGT	0.662													4	73					0	0	0	0	C	46057446	C	C	46057446	2	2	1	1	0	0	0	0	0	0	0	1	8545	1606	56	5		5	KRTAP10-10	21	46057446	Silent	SNP	T	TCGA-BA-4074-01A-01D-1434-08	219581	46057446	2072449	169	169											
COL6A1	1291	broad.mit.edu	37	chr21	47410318	47410318	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagggcaagcgtggcatcgaCggggtggacggcgtgaaggt	9	5	20	7	5	0	1	0	1	0	0	1	3	0	2	0	7	1	2	0	7	3	0			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr21:47410318C>T	uc002zhu.1	+	13	1086	c.984C>T	c.(982-984)GAC>GAT	p.D328D		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	328	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GTGGCATCGACGGGGTGGACG	0.438													19	56					0	0	0	0	T	47410318	T	T	47410318	2	4	1	1	0	0	0	0	0	0	0	1	3714	535	19	1		1	COL6A1	21	47410318	Silent	SNP	C	TCGA-BA-4074-01A-01D-1434-08	1352872	47410318	719577	170	170											
ZC3H7B	23264	broad.mit.edu	37	chr22	41736067	41736067	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctggacctgctgccgtactCggagacccggctggatgcac	6	7	13	15	3	0	1	0	0	0	1	1	4	0	3	4	4	4	4	4	4	1	1			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chr22:41736067C>T	uc003azw.2	+	10	1280	c.1064C>T	c.(1063-1065)TCG>TTG	p.S355L	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	371					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						CTGCCGTACTCGGAGACCCGG	0.652													20	61					0	0	0	0	T	41736067	T	T	41736067	3	4	1	1	0	0	0	0	1	0	0	0	17640	893	31	1	1098	1	ZC3H7B	22	41736067	Missense_Mutation	SNP	C	TCGA-BA-4074-01A-01D-1434-08		41736067	9568499	171	171											
FAM47A	158724	broad.mit.edu	37	chrX	34149589	34149589	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtcttccagcttcctctcAgaatccagtttcagcagctg	7	12	8	14	1	3	1	2	0	2	1	7	1	6	1	3	0	3	4	3	0	1	3			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chrX:34149589A>C	uc004ddg.2	-	1	840	c.807T>G	c.(805-807)TCT>TCG	p.S269S		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	269										ovary(4)|central_nervous_system(1)	5						GCTTCCTCTCAGAATCCAGTT	0.587													22	26					0	0	0	0	C	34149589	C	C	34149589	2	2	1	1	0	0	0	0	0	0	0	1	5601	175	7	5		5	FAM47A	23	34149589	Silent	SNP	A	TCGA-BA-4074-01A-01D-1434-08		34149589	121120971	172	172											
SRPX	8406	broad.mit.edu	37	chrX	38024064	38024064	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctcttccttcgggtgtcTcccaggacacccggactgtc	4	12	10	15	2	2	0	0	0	2	0	7	2	3	2	3	3	0	0	3	3	0	2			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chrX:38024064T>A	uc004ddy.1	-	5	697	c.611A>T	c.(610-612)GAG>GTG	p.E204V	SRPX_uc004ddz.1_Missense_Mutation_p.E184V|SRPX_uc011mkh.1_Missense_Mutation_p.E145V|SRPX_uc011mki.1_Missense_Mutation_p.E204V	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	204	HYR.				cell adhesion	cell surface|membrane					0						TTCGGGTGTCTCCCAGGACAC	0.433													5	34					0	0	0	0	A	38024064	A	A	38024064	3	1	1	1	0	0	0	0	1	0	0	0	15230	1551	54	5	807	5	SRPX	23	38024064	Missense_Mutation	SNP	T	TCGA-BA-4074-01A-01D-1434-08	3874475	38024064	117246496	173	173											
MUM1L1	139221	broad.mit.edu	37	chrX	105450134	105450134	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgttaaagatgaaaagtttGctccacctttgtcacctttg	10	15	8	8	0	1	2	1	1	0	1	2	2	2	2	3	0	1	3	3	0	4	4			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chrX:105450134G>T	uc004emf.1	+	4	1358	c.709G>T	c.(709-711)GCT>TCT	p.A237S	MUM1L1_uc004emg.1_Missense_Mutation_p.A237S	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	237										ovary(2)|pancreas(1)|skin(1)	4						TGAAAAGTTTGCTCCACCTTT	0.418													15	10					2.23348e-06	2.31577e-06	1	0	T	105450134	T	T	105450134	3	4	1	1	0	0	0	0	1	0	0	0	10039	1319	46	4	711	4	MUM1L1	23	105450134	Missense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	67426070	105450134	49820426	174	174											
ODZ1	10178	broad.mit.edu	37	chrX	123699280	123699280	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactcacattttccatctttGcattggccatgctcagtaca	9	14	5	13	0	3	0	2	0	1	0	4	0	4	0	2	1	3	3	2	1	1	5			TCGA-BA-4074-01A-01D-1434-08	TCGA-BA-4074-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c84e904-0cbc-4645-b7e5-94ec45e61268	c28b58ca-f8e1-4063-908e-3ecf58104b68	g.chrX:123699280G>T	uc004euj.2	-	12	2272	c.2208C>A	c.(2206-2208)TGC>TGA	p.C736*	ODZ1_uc011muj.1_Nonsense_Mutation_p.C735*|ODZ1_uc010nqy.2_Nonsense_Mutation_p.C736*	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	736	EGF-like 7.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTCCATCTTTGCATTGGCCAT	0.468													4	56					0.00909568	0.00918897	1	0	T	123699280	T	T	123699280	4	4	1	1	0	0	0	0	0	1	0	0	10888	1311	46	4	6074	4	ODZ1	23	123699280	Nonsense_Mutation	SNP	G	TCGA-BA-4074-01A-01D-1434-08	18249146	123699280	31571280	175	175											
RERE	473	broad.mit.edu	37	chr1	8616534	8616534	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcacgtctccagtacttacCtaagggcagcagcatggtaa	12	8	10	11	1	1	0	0	0	1	0	2	0	1	0	2	2	5	6	2	2	4	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:8616534C>G	uc001ape.2	-	7	1535	c.725G>C	c.(724-726)AGA>ACA	p.R242T	RERE_uc001apf.2_Missense_Mutation_p.R242T|RERE_uc001aph.1_Missense_Mutation_p.R242T	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	242	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CAGTACTTACCTAAGGGCAGC	0.443													45	320					0	0	0	0	G	8616534	G	G	8616534	3	3	2	1	0	0	0	0	1	0	0	0	13296	695	24	4	4047	4	RERE	1	8616534	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08		8616534	240634087	1	176											
USP48	84196	broad.mit.edu	37	chr1	22016569	22016569	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaaattctggtcaaaaggAgcaactgaaaatgcatgcat	17	8	9	7	0	2	1	1	1	1	0	2	3	2	2	0	2	4	3	0	2	6	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:22016569A>G	uc001bfb.2	-	24	3145	c.2907T>C	c.(2905-2907)GCT>GCC	p.A969A	USP48_uc001bfa.2_Silent_p.A455A|USP48_uc010odq.1_Silent_p.A981A|USP48_uc009vqc.2_Silent_p.A903A|USP48_uc001bfc.2_Silent_p.A917A|USP48_uc001bfd.1_Silent_p.A94A	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	969	Ubiquitin-like.				ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		GGTCAAAAGGAGCAACTGAAA	0.358													26	65					0	0	0	0	G	22016569	G	G	22016569	2	3	2	1	0	0	0	0	0	0	0	1	17147	291	11	5		5	USP48	1	22016569	Silent	SNP	A	TCGA-BA-4075-01A-01D-1434-08	13400035	22016569	227234052	2	177											
FABP3	2170	broad.mit.edu	37	chr1	31840248	31840248	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcccatcttaccaggatgaGttttccatcaattagctccc	9	13	6	13	0	2	1	1	1	1	0	4	2	4	2	4	1	3	2	4	1	3	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:31840248G>A	uc001bss.1	-	3	402	c.340C>T	c.(340-342)CTC>TTC	p.L114F		NM_004102	NP_004093	P05413	FABPH_HUMAN	fatty acid binding protein 3	114					negative regulation of cell proliferation					ovary(1)	1		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0185)|READ - Rectum adenocarcinoma(331;0.149)		ACCAGGATGAGTTTTCCATCA	0.478													101	265					0	0	0	0	A	31840248	A	A	31840248	3	1	2	1	0	0	0	0	1	0	0	0	5386	1029	36	4	69	4	FABP3	1	31840248	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	9823679	31840248	217410373	3	178											
RRAGC	64121	broad.mit.edu	37	chr1	39322630	39322630	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggttgggtcaaaaaagtccAtttgcccaggaaaatcccat	14	9	9	9	0	1	0	1	0	0	0	3	1	3	1	3	3	1	1	3	3	5	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:39322630A>C	uc001ccq.2	-	2	384	c.362T>G	c.(361-363)ATG>AGG	p.M121R	RRAGC_uc010oim.1_Missense_Mutation_p.M87R|RRAGC_uc001ccr.2_Missense_Mutation_p.M43R	NM_022157	NP_071440	Q9HB90	RRAGC_HUMAN	Ras-related GTP binding C	121					apoptosis|cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|RNA splicing|small GTPase mediated signal transduction|transcription, DNA-dependent	lysosome|nucleus	GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein heterodimerization activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)				AAAAAAGTCCATTTGCCCAGG	0.398													62	177					0	0	0	0	C	39322630	C	C	39322630	3	2	2	1	0	0	0	0	1	0	0	0	13739	217	8	5	861	5	RRAGC	1	39322630	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	7482382	39322630	209927991	4	179											
TMEM53	79639	broad.mit.edu	37	chr1	45120269	45120270	+	Missense_Mutation	DNP	GG	TT	TT																															gcgcatgaagtcgacacagaGgcttgtgtagtaagtagggt																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:45120269_45120270GG>TT	uc001cmc.2	-	3	831_832	c.795_796CC>AA	c.(793-798)AGCCTC>AGAATC	p.265_266SL>RI	TMEM53_uc001cmb.1_Intron|TMEM53_uc001cmd.2_Missense_Mutation_p.192_193SL>RI|TMEM53_uc009vxh.1_Missense_Mutation_p.148_149SL>RI|TMEM53_uc010ola.1_Missense_Mutation_p.148_149SL>RI	NM_024587	NP_078863	Q6P2H8	TMM53_HUMAN	transmembrane protein 53	265_266						integral to membrane				ovary(2)	2	Acute lymphoblastic leukemia(166;0.155)					TCGACACAGAGGCTTGTGTAGT	0.584													14	87					0	0	0	0	TT	45120270	TT	TT	45120269	3	4	2	1	0	0	0	0	1	0	0	0	16245	1000	35	4	41	4	TMEM53	1	45120269	Missense_Mutation	DNP	GG	TCGA-BA-4075-01A-01D-1434-08	5797639	45120269	204130352	5	180											
NASP	4678	broad.mit.edu	37	chr1	46073529	46073529	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgggtggggacgagccagagGagaaggtagttacctctgaa	11	7	17	6	1	1	3	0	1	1	2	1	6	1	4	2	5	2	2	2	5	4	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:46073529G>T	uc001coi.1	+	6	1048	c.946G>T	c.(946-948)GAG>TAG	p.E316*	NASP_uc010olq.1_Nonsense_Mutation_p.E279*|NASP_uc001coh.1_Nonsense_Mutation_p.E318*|NASP_uc001coj.1_Intron|NASP_uc010olr.1_Nonsense_Mutation_p.E252*|NASP_uc001cok.1_Nonsense_Mutation_p.E199*	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	316	Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					CGAGCCAGAGGAGAAGGTAGT	0.527													5	57					0.00116845	0.00124019	1	0	T	46073529	T	T	46073529	4	4	2	1	0	0	0	0	0	1	0	0	10225	1175	41	2	1045	2	NASP	1	46073529	Nonsense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	953260	46073529	203177092	6	181											
TGFBR3	7049	broad.mit.edu	37	chr1	92177865	92177866	+	Missense_Mutation	DNP	GC	AA	AA																															cagctcacactgtagaaagaGcagtgaggtgttgaagacag																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:92177865_92177866GC>AA	uc001doh.2	-	13	2566_2567	c.2100_2101GC>TT	c.(2098-2103)CTGCTC>CTTTTC	p.L701F	TGFBR3_uc009wde.2_Intron|TGFBR3_uc010osy.1_Missense_Mutation_p.L659F|TGFBR3_uc001doi.2_Missense_Mutation_p.L700F|TGFBR3_uc001doj.2_Missense_Mutation_p.L700F	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	701	ZP.|Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TGTAGAAAGAGCAGTGAGGTGT	0.475													21	48					0	0	0	0	AA	92177866	AA	AA	92177865	3	1	2	1	0	0	0	0	1	0	0	0	15889	971	34	4	474	4	TGFBR3	1	92177865	Missense_Mutation	DNP	GC	TCGA-BA-4075-01A-01D-1434-08	46104336	92177865	157072756	7	182											
GPR61	83873	broad.mit.edu	37	chr1	110086823	110086823	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggactggctgtccttctgaGtcctgggtttcccgacccct	3	12	12	14	1	1	1	0	1	1	0	4	3	4	2	5	3	0	2	5	3	0	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:110086823G>A	uc001dxy.2	+	2	1862	c.1179G>A	c.(1177-1179)GAG>GAA	p.E393E		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	393	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		GTCCTTCTGAGTCCTGGGTTT	0.602													22	49					0	0	0	0	A	110086823	A	A	110086823	2	1	2	1	0	0	0	0	0	0	0	1	6740	1020	36	4		4	GPR61	1	110086823	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	17908958	110086823	139163798	8	183											
C1orf103	55791	broad.mit.edu	37	chr1	111494644	111494644	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttggaaaatccatttcactgGagcagcttgagaatgctgac	12	11	10	8	0	1	2	1	2	0	1	2	5	2	4	1	2	3	3	1	2	3	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:111494644G>T	uc001eaa.2	-	2	1118	c.862C>A	c.(862-864)CCA>ACA	p.P288T	C1orf103_uc001dzz.2_Intron|C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	288					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		CATTTCACTGGAGCAGCTTGA	0.358													72	114					3.19358e-47	3.86423e-47	1	0	T	111494644	T	T	111494644	3	4	2	1	0	0	0	0	1	0	0	0	1986	1174	41	2	1459	2	C1orf103	1	111494644	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	1407821	111494644	137755977	9	184											
RPRD2	23248	broad.mit.edu	37	chr1	150443141	150443141	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaacaccacagtctctaccAtaaagggaagaaatctgccc	15	6	6	14	0	2	1	0	0	2	1	3	2	2	2	4	1	3	0	4	1	6	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:150443141A>G	uc009wlr.2	+	11	1918	c.1717A>G	c.(1717-1719)ATA>GTA	p.I573V	RPRD2_uc010pcc.1_Missense_Mutation_p.I547V|RPRD2_uc001eup.3_Missense_Mutation_p.I547V	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	573	Ser-rich.						protein binding			ovary(1)	1						AGTCTCTACCATAAAGGGAAG	0.478													4	65					0	0	0	0	G	150443141	G	G	150443141	3	3	2	1	0	0	0	0	1	0	0	0	13682	217	8	5	1759	5	RPRD2	1	150443141	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	38948497	150443141	98807480	10	185											
TMOD4	29765	broad.mit.edu	37	chr1	151146931	151146931	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttctagtgcctgttgctcCaagtactgcaaaagggcctc	9	11	9	12	0	1	0	0	0	1	0	3	0	2	0	3	1	4	4	3	1	5	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:151146931C>T	uc001exc.3	-	3	406	c.216G>A	c.(214-216)TTG>TTA	p.L72L	TMOD4_uc001exb.2_5'Flank|TMOD4_uc001exd.2_RNA|TMOD4_uc010pct.1_Silent_p.L72L	NM_013353	NP_037485	Q9NZQ9	TMOD4_HUMAN	tropomodulin 4 (muscle)	72					muscle contraction	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCTGTTGCTCCAAGTACTGCA	0.552													73	288					0	0	0	0	T	151146931	T	T	151146931	2	4	2	1	0	0	0	0	0	0	0	1	16302	593	21	4		4	TMOD4	1	151146931	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	703790	151146931	98103690	11	186											
ASH1L	55870	broad.mit.edu	37	chr1	155450127	155450127	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcagggatttttaaagtcCttttaggtggcccttccagt	9	14	10	8	0	0	0	0	0	0	0	2	1	2	1	3	3	1	1	3	3	4	6			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:155450127C>T	uc009wqq.2	-	3	3014	c.2534G>A	c.(2533-2535)AGG>AAG	p.R845K	ASH1L_uc001fkt.2_Missense_Mutation_p.R845K|ASH1L_uc009wqr.1_Missense_Mutation_p.R845K	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	845					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TTTTAAAGTCCTTTTAGGTGG	0.393													8	269					0	0	0	0	T	155450127	T	T	155450127	3	4	2	1	0	0	0	0	1	0	0	0	1043	681	24	4	6464	4	ASH1L	1	155450127	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	4303196	155450127	93800494	12	187											
GON4L	54856	broad.mit.edu	37	chr1	155744843	155744843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtcaatgctgacatgtgtgCtgaagtcttcaatcagctgc	10	12	10	9	0	4	2	3	2	1	0	4	2	4	2	0	0	4	3	0	0	3	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:155744843C>T	uc001flz.2	-	17	2397	c.2300G>A	c.(2299-2301)AGC>AAC	p.S767N	GON4L_uc001fly.1_Missense_Mutation_p.S767N|GON4L_uc009wrh.1_Missense_Mutation_p.S767N|GON4L_uc001fma.1_Missense_Mutation_p.S767N|GON4L_uc001fmb.3_5'UTR|GON4L_uc001fmc.2_Missense_Mutation_p.S767N|GON4L_uc001fmd.3_Missense_Mutation_p.S767N|GON4L_uc009wri.2_Missense_Mutation_p.S353N|GON4L_uc009wrj.1_Missense_Mutation_p.S253N|GON4L_uc001fme.2_Missense_Mutation_p.S595N	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	767					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GACATGTGTGCTGAAGTCTTC	0.478													47	18					0	0	0	0	T	155744843	T	T	155744843	3	4	2	1	0	0	0	0	1	0	0	0	6609	797	28	4	4603	4	GON4L	1	155744843	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	294716	155744843	93505778	13	188											
HAPLN2	60484	broad.mit.edu	37	chr1	156594410	156594410	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cagcttggaccgagggtctgGactggtgtaacgcgggctgg	6	8	18	9	3	1	0	0	0	1	0	1	3	1	2	1	6	2	3	1	6	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:156594410G>C	uc001fpn.1	+	6	981	c.574G>C	c.(574-576)GAC>CAC	p.D192H		NM_021817	NP_068589	Q9GZV7	HPLN2_HUMAN	brain link protein-1 precursor	192	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGAGGGTCTGGACTGGTGTAA	0.726													4	34					0	0	0	0	C	156594410	C	C	156594410	3	2	2	1	0	0	0	0	1	0	0	0	6994	1174	41	2	588	2	HAPLN2	1	156594410	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	849567	156594410	92656211	14	189											
POU2F1	5451	broad.mit.edu	37	chr1	167384851	167384851	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccctctgttcctgaaccCtcagaacctctctctgctca	6	12	5	18	0	5	2	2	1	3	1	7	2	6	2	5	0	4	2	5	0	2	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:167384851C>T	uc001gec.2	+	17	2198	c.2036C>T	c.(2035-2037)CCT>CTT	p.P679L	POU2F1_uc001ged.2_Missense_Mutation_p.P677L|POU2F1_uc001gee.2_Missense_Mutation_p.P679L|POU2F1_uc010plh.1_Missense_Mutation_p.P616L|POU2F1_uc001gef.2_Missense_Mutation_p.P691L|POU2F1_uc001geg.2_Intron	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	679					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						TTCCTGAACCCTCAGAACCTC	0.572													16	205					0	0	0	0	T	167384851	T	T	167384851	3	4	2	1	0	0	0	0	1	0	0	0	12326	681	24	4	2094	4	POU2F1	1	167384851	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	10790441	167384851	81865770	15	190											
ZNF648	127665	broad.mit.edu	37	chr1	182026716	182026716	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcatcacccgcaggtagtcGgtccccaagaggttgcatct	9	9	10	13	2	3	1	2	0	1	1	5	1	4	1	3	3	1	4	3	3	2	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:182026716G>A	uc001goz.2	-	2	638	c.430C>T	c.(430-432)CGA>TGA	p.R144*		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCAGGTAGTCGGTCCCCAAGA	0.577													68	45					0	0	0	0	A	182026716	A	A	182026716	4	1	2	1	0	0	0	0	0	1	0	0	18130	1124	39	1	1280	1	ZNF648	1	182026716	Nonsense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	14641865	182026716	67223905	16	191											
CACNA1S	779	broad.mit.edu	37	chr1	201013550	201013550	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaccgtgcgacagatctcgGgggctgcctcttcctcaatg	7	9	12	13	3	3	2	1	0	2	2	5	3	4	2	3	2	2	1	3	2	1	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:201013550G>T	uc001gvv.2	-	39	4930	c.4703C>A	c.(4702-4704)CCC>CAC	p.P1568H		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1568	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ACAGATCTCGGGGGCTGCCTC	0.597													5	117					8.12818e-05	8.90055e-05	1	0	T	201013550	T	T	201013550	3	4	2	1	0	0	0	0	1	0	0	0	2559	1232	43	4	942	4	CACNA1S	1	201013550	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	18986834	201013550	48237071	17	192											
LMOD1	25802	broad.mit.edu	37	chr1	201868533	201868533	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggagccaagggagggggaggGggtggtggggcagctggagc	7	3	26	5	0	0	0	0	0	0	0	0	4	0	4	1	10	3	2	1	10	1	0			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:201868533G>A	uc001gxb.2	-	2	1856	c.1608C>T	c.(1606-1608)CCC>CCT	p.P536P	LMOD1_uc010ppu.1_Silent_p.P485P	NM_012134	NP_036266	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	536					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			ovary(1)|pancreas(1)|skin(1)	3						GAGGGGGAGGGGGTGGTGGGG	0.577													3	38					0	0	0	0	A	201868533	A	A	201868533	2	1	2	1	0	0	0	0	0	0	0	1	8898	1219	43	4		4	LMOD1	1	201868533	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	854983	201868533	47382088	18	193											
USH2A	7399	broad.mit.edu	37	chr1	216073542	216073542	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcatagcttaacgatgcaGaaggattggaaaataacctg	15	10	9	7	1	1	1	1	0	0	1	1	4	1	3	1	2	4	2	1	2	6	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:216073542G>C	uc001hku.1	-	40	7856	c.7469C>G	c.(7468-7470)TCT>TGT	p.S2490C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2490	Extracellular (Potential).|Fibronectin type-III 11.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAACGATGCAGAAGGATTGGA	0.358										HNSCC(13;0.011)			3	101					0	0	0	0	C	216073542	C	C	216073542	3	2	2	1	0	0	0	0	1	0	0	0	17104	942	33	2	8271	2	USH2A	1	216073542	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	14205009	216073542	33177079	19	194											
ESRRG	2104	broad.mit.edu	37	chr1	216850602	216850602	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcatacagtttcctgacAggcccactacctcccaggat	10	10	6	15	0	2	1	2	1	0	0	4	2	4	2	4	2	2	1	4	2	2	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:216850602A>T	uc001hkw.1	-	2	454	c.288T>A	c.(286-288)CCT>CCA	p.P96P	ESRRG_uc001hky.1_Silent_p.P73P|ESRRG_uc009xdp.1_Silent_p.P73P|ESRRG_uc001hkz.1_Silent_p.P73P|ESRRG_uc010puc.1_Silent_p.P73P|ESRRG_uc001hla.1_Silent_p.P73P|ESRRG_uc001hlb.1_Silent_p.P73P|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Silent_p.P73P|ESRRG_uc001hld.1_Silent_p.P73P|ESRRG_uc001hkx.1_Silent_p.P101P|ESRRG_uc009xdo.1_Silent_p.P73P|ESRRG_uc001hle.1_Silent_p.P73P	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	96					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	GTTTCCTGACAGGCCCACTAC	0.517													18	221					0	0	0	0	T	216850602	T	T	216850602	2	4	2	1	0	0	0	0	0	0	0	1	5286	175	7	5		5	ESRRG	1	216850602	Silent	SNP	A	TCGA-BA-4075-01A-01D-1434-08	777060	216850602	32400019	20	195											
URB2	9816	broad.mit.edu	37	chr1	229772124	229772124	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccctgctggcccttctcccGgacaccccaggcccagagcc	5	5	9	22	1	1	1	0	0	1	1	2	2	1	2	8	3	2	1	8	3	0	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:229772124G>C	uc001hts.1	+	4	1900	c.1764G>C	c.(1762-1764)CCG>CCC	p.P588P	URB2_uc009xfd.1_Silent_p.P588P	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	588						nucleolus				central_nervous_system(2)|ovary(1)	3						CCCTTCTCCCGGACACCCCAG	0.612													5	243					0	0	0	0	C	229772124	C	C	229772124	2	2	2	1	0	0	0	0	0	0	0	1	17093	1103	39	3		3	URB2	1	229772124	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	12921522	229772124	19478497	21	196											
EXO1	9156	broad.mit.edu	37	chr1	242030178	242030178	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatgacaaaacatgtcaaaAgtcagctaatgttagcagca	17	8	9	7	0	2	1	2	1	0	0	2	2	2	2	0	1	4	4	0	1	6	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:242030178A>C	uc001hzh.2	+	11	1628	c.1088A>C	c.(1087-1089)AAG>ACG	p.K363T	EXO1_uc001hzi.2_Missense_Mutation_p.K363T|EXO1_uc001hzj.2_Missense_Mutation_p.K363T|EXO1_uc009xgq.2_Missense_Mutation_p.K363T	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	363	Interaction with MSH3.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			ACATGTCAAAAGTCAGCTAAT	0.378								Direct_reversal_of_damage|Editing_and_processing_nucleases					9	168					0	0	0	0	C	242030178	C	C	242030178	3	2	2	1	0	0	0	0	1	0	0	0	5324	72	3	5	1118	5	EXO1	1	242030178	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	12258054	242030178	7220443	22	197											
CEP170	9859	broad.mit.edu	37	chr1	243354341	243354341	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcaaccttttcaagtacaCtggaacatcacttttaatgc	12	15	4	10	0	3	0	3	0	0	0	3	1	3	1	1	1	4	1	1	1	5	6			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:243354341C>A	uc001hzs.2	-	8	1495	c.1087G>T	c.(1087-1089)GTG>TTG	p.V363L	CEP170_uc001hzt.2_Missense_Mutation_p.V363L|CEP170_uc001hzu.2_Missense_Mutation_p.V363L	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	363						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TTCAAGTACACTGGAACATCA	0.363													3	23					0.00909568	0.00932693	1	0	A	243354341	A	A	243354341	3	1	2	1	0	0	0	0	1	0	0	0	3265	565	20	4	3749	4	CEP170	1	243354341	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	1324163	243354341	5896280	23	198											
OR6F1	343169	broad.mit.edu	37	chr1	247875881	247875881	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggttgctcagaaagaagtaCatgggggtatgcaactgatg	13	9	14	5	0	1	3	1	1	0	2	1	3	1	3	0	3	4	5	0	3	5	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:247875881C>A	uc001idj.1	-	1	177	c.177G>T	c.(175-177)ATG>ATT	p.M59I		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GAAAGAAGTACATGGGGGTAT	0.478													8	128					1.12685e-05	1.25667e-05	1	0	A	247875881	A	A	247875881	3	1	2	1	0	0	0	0	1	0	0	0	11255	478	17	4	753	4	OR6F1	1	247875881	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	4521540	247875881	1374740	24	199											
OR2M4	26245	broad.mit.edu	37	chr1	248402903	248402903	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcccatgtccttcgagccGtcatccacatgggctctggg	6	11	10	14	2	2	0	1	0	1	0	6	1	5	0	4	2	1	1	4	2	0	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr1:248402903G>A	uc010pzh.1	+	1	673	c.673G>A	c.(673-675)GTC>ATC	p.V225I		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCTTCGAGCCGTCATCCACAT	0.473													7	70					0	0	0	0	A	248402903	A	A	248402903	3	1	2	1	0	0	0	0	1	0	0	0	11066	1145	40	1	675	1	OR2M4	1	248402903	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	527022	248402903	847718	25	200											
OXER1	165140	broad.mit.edu	37	chr2	42991086	42991086	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtggcagggccctccagaGgacccccccacagtggtaaa	9	4	14	14	0	0	1	0	0	0	1	1	2	1	2	5	5	0	2	5	5	2	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr2:42991086G>A	uc002rss.2	-	1	316	c.234C>T	c.(232-234)TCC>TCT	p.S78S		NM_148962	NP_683765	Q8TDS5	OXER1_HUMAN	G-protein coupled receptor TG1019	78	Extracellular (Potential).|Ser-rich.				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)	1						GCCCTCCAGAGGACCCCCCCA	0.393													7	53					0	0	0	0	A	42991086	A	A	42991086	2	1	2	1	0	0	0	0	0	0	0	1	11385	987	35	4		4	OXER1	2	42991086	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08		42991086	200208287	26	201											
NAT8	9027	broad.mit.edu	37	chr2	73868718	73868718	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccacaacccactggcggTcgctctcctggtatttgcgg	6	9	11	15	3	1	0	0	0	1	0	3	0	1	0	3	4	3	2	3	4	2	2	rs74434404		TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr2:73868718T>C	uc002sji.1	-	2	205	c.38A>G	c.(37-39)GAC>GGC	p.D13G		NM_003960	NP_003951	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8	13					gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			ovary(1)	1						CCACTGGCGGTCGCTCTCCTG	0.587													11	161					0	0	0	0	C	73868718	C	C	73868718	3	2	2	1	0	0	0	0	1	0	0	0	10232	1667	58	5	649	5	NAT8	2	73868718	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	30877632	73868718	169330655	27	202											
ARID5A	10865	broad.mit.edu	37	chr2	97218002	97218002	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctggcacgcaccaccagtCacaacctatgcagcgcccca	10	4	8	19	2	1	0	1	0	0	0	1	0	1	0	6	1	3	3	6	1	2	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr2:97218002C>A	uc002swe.2	+	7	1837	c.1737C>A	c.(1735-1737)GTC>GTA	p.V579V	ARID5A_uc010yuq.1_Silent_p.V527V|ARID5A_uc002swf.2_Silent_p.V415V|ARID5A_uc002swg.2_Silent_p.V527V	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A	579					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding				0						CACCACCAGTCACAACCTATG	0.617													36	134					1.69901e-12	1.99593e-12	1	0	A	97218002	A	A	97218002	2	1	2	1	0	0	0	0	0	0	0	1	921	813	29	2		2	ARID5A	2	97218002	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	23349284	97218002	145981371	28	203											
LRP1B	53353	broad.mit.edu	37	chr2	141110541	141110542	+	Frame_Shift_Ins	INS	-	TT	TT																															cttctgctatgcaggtgttaINStttctttcttgaaaattctg																								rs144480841		TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr2:141110541_141110542insTT	uc002tvj.1	-	76	12602_12603	c.11630_11631insAA	c.(11629-11631)AATfs	p.N3877fs		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3877	Extracellular (Potential).|EGF-like 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGCAGGTGTTATTTCTTTCTTG	0.307										TSP Lung(27;0.18)			---	---	---								TT	141110542	TT	TT	141110541	7	5	2	1	0	1	1	0	0	0	0	0	9005	446	16	0	2232	0	LRP1B	2	141110541	Frame_Shift_Ins	INS	-	TCGA-BA-4075-01A-01D-1434-08	43892539	141110541	102088832	29	204											
ZEB2	9839	broad.mit.edu	37	chr2	145157513	145157513	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caagcccaccattcataaagGgactagtgccactaaacccg	14	6	7	14	1	1	0	1	0	0	0	1	1	1	1	4	1	3	0	4	1	6	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr2:145157513G>T	uc002tvu.2	-	8	1721	c.1241C>A	c.(1240-1242)CCC>CAC	p.P414H	ZEB2_uc002tvv.2_Missense_Mutation_p.P408H|ZEB2_uc010zbm.1_Missense_Mutation_p.P385H|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.P443H	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	414						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		ATTCATAAAGGGACTAGTGCC	0.448													6	140					0.00198382	0.00206933	1	0	T	145157513	T	T	145157513	3	4	2	1	0	0	0	0	1	0	0	0	17691	1232	43	4	2415	4	ZEB2	2	145157513	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	4046972	145157513	98041860	30	205											
RIF1	55183	broad.mit.edu	37	chr2	152324992	152324992	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctttcttctatctagcataAtaccacttcagccaaaggat	12	13	4	12	0	4	0	1	0	3	0	4	1	4	1	3	1	3	1	3	1	5	7			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr2:152324992A>G	uc002txm.2	+	32	6882	c.6752A>G	c.(6751-6753)AAT>AGT	p.N2251S	RIF1_uc002txl.2_Intron|RIF1_uc002txn.2_Intron|RIF1_uc002txo.2_Intron|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	2251	Interaction with condensed chromosomes in telophase.				cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		ATCTAGCATAATACCACTTCA	0.348													60	205					0	0	0	0	G	152324992	G	G	152324992	3	3	2	1	0	0	0	0	1	0	0	0	13424	101	4	5	6874	5	RIF1	2	152324992	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	7167479	152324992	90874381	31	206											
XIRP2	129446	broad.mit.edu	37	chr2	168100963	168100963	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taagaagctgtaggtggcttTttgaaacaaggcccattgac	12	11	11	7	0	0	3	0	2	0	1	0	3	0	3	1	3	2	3	1	3	5	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr2:168100963T>G	uc002udx.2	+	8	3079	c.3061T>G	c.(3061-3063)TTT>GTT	p.F1021V	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.F846V|XIRP2_uc010fpq.2_Missense_Mutation_p.F799V|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	846	Xin 14.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TAGGTGGCTTTTTGAAACAAG	0.368													6	93					0	0	0	0	G	168100963	G	G	168100963	3	3	2	1	0	0	0	0	1	0	0	0	17498	1841	64	5	3091	5	XIRP2	2	168100963	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	15775971	168100963	75098410	32	207											
XIRP2	129446	broad.mit.edu	37	chr2	168106123	168106123	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaatctgagattgatgttCaaacctttaccaaaaaacaa	18	10	5	8	0	2	2	1	2	1	1	2	3	2	2	2	0	4	2	2	0	7	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr2:168106123C>A	uc002udx.2	+	8	8239	c.8221C>A	c.(8221-8223)CAA>AAA	p.Q2741K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.Q2566K|XIRP2_uc010fpq.2_Missense_Mutation_p.Q2519K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.Q87K	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2566					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GATTGATGTTCAAACCTTTAC	0.338													11	130					1.58986e-06	1.78952e-06	1	0	A	168106123	A	A	168106123	3	1	2	1	0	0	0	0	1	0	0	0	17498	827	29	2	8251	2	XIRP2	2	168106123	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	5160	168106123	75093250	33	208											
SLC19A3	80704	broad.mit.edu	37	chr2	228560672	228560672	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccagcatagcacgcccagaTattggctgtgtaatgcatga	11	9	11	10	1	0	2	0	1	0	1	0	2	0	2	2	1	3	5	2	1	3	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr2:228560672T>C	uc002vpi.2	-	4	1194	c.1105A>G	c.(1105-1107)ATC>GTC	p.I369V	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.I365V	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	369	Extracellular (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	CACGCCCAGATATTGGCTGTG	0.428													6	109					0	0	0	0	C	228560672	C	C	228560672	3	2	2	1	0	0	0	0	1	0	0	0	14495	1406	49	5	397	5	SLC19A3	2	228560672	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	60454549	228560672	14638701	34	209											
FBXL2	25827	broad.mit.edu	37	chr3	33427049	33427049	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcccgtcaccccaccgacAgcagtggcaggaagtggaca	10	4	12	15	2	1	0	1	0	0	0	2	3	2	2	4	3	1	3	4	3	1	0			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr3:33427049A>G	uc003cfp.2	+	15	1292	c.1221A>G	c.(1219-1221)ACA>ACG	p.T407T	FBXL2_uc011axm.1_RNA|FBXL2_uc011axn.1_RNA|FBXL2_uc011axo.1_Silent_p.T302T|FBXL2_uc011axp.1_Silent_p.T323T|FBXL2_uc011axq.1_RNA|FBXL2_uc011axr.1_RNA|FBXL2_uc011axs.1_RNA	NM_012157	NP_036289	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	407					interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			large_intestine(1)	1						CCCCACCGACAGCAGTGGCAG	0.532													11	220					0	0	0	0	G	33427049	G	G	33427049	2	3	2	1	0	0	0	0	0	0	0	1	5748	175	7	5		5	FBXL2	3	33427049	Silent	SNP	A	TCGA-BA-4075-01A-01D-1434-08		33427049	164595381	35	210											
LARS2	23395	broad.mit.edu	37	chr3	45500356	45500356	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtacctcagacaatggtttaTtaagacaaccgcttatgcaa	14	11	7	9	1	1	2	1	0	0	2	1	2	1	2	2	1	3	4	2	1	7	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr3:45500356T>G	uc003cop.1	+	8	913	c.728T>G	c.(727-729)ATT>AGT	p.I243S	LARS2_uc010hit.1_Missense_Mutation_p.I200S	NM_015340	NP_056155	Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	243					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	CAATGGTTTATTAAGACAACC	0.498													24	45					0	0	0	0	G	45500356	G	G	45500356	3	3	2	1	0	0	0	0	1	0	0	0	8675	1493	52	5	750	5	LARS2	3	45500356	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	12073307	45500356	152522074	36	211											
GPR15	2838	broad.mit.edu	37	chr3	98251043	98251043	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggggaaccttgttctcatgGgagcgttgcatttcaaaccc	8	12	11	10	1	2	0	2	0	1	0	3	2	2	2	2	3	4	3	2	3	2	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr3:98251043G>A	uc011bgy.1	+	1	166	c.166G>A	c.(166-168)GGA>AGA	p.G56R		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	56	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		TGTTCTCATGGGAGCGTTGCA	0.498													9	111					0	0	0	0	A	98251043	A	A	98251043	3	1	2	1	0	0	0	0	1	0	0	0	6693	1233	43	4	168	4	GPR15	3	98251043	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	52750687	98251043	99771387	37	212											
C3orf15	89876	broad.mit.edu	37	chr3	119458167	119458167	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccggggcagagtcgttcaGaacatggtgtgtaggtccaa	9	9	14	9	2	1	2	1	0	0	2	4	2	3	2	2	4	1	3	2	4	3	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr3:119458167G>A	uc003ede.3	+	12	1604	c.1527G>A	c.(1525-1527)CAG>CAA	p.Q509Q	C3orf15_uc010hqy.1_Silent_p.Q509Q|C3orf15_uc010hqz.2_Silent_p.Q447Q|C3orf15_uc011bjd.1_Silent_p.Q383Q|C3orf15_uc011bje.1_Silent_p.Q489Q|C3orf15_uc010hra.1_Silent_p.Q270Q	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	345						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		GAGTCGTTCAGAACATGGTGT	0.428													26	215					0	0	0	0	A	119458167	A	A	119458167	2	1	2	1	0	0	0	0	0	0	0	1	2219	933	33	2		2	C3orf15	3	119458167	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	21207124	119458167	78564263	38	213											
HGD	3081	broad.mit.edu	37	chr3	120365175	120365175	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctccaagatgtagcccctGgtctcctcaaagacatctat	11	10	6	14	0	3	2	1	0	2	2	5	2	4	2	5	1	1	1	5	1	4	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr3:120365175G>A	uc003edw.2	-	9	958	c.588C>T	c.(586-588)ACC>ACT	p.T196T	HGD_uc003edv.2_Silent_p.T55T	NM_000187	NP_000178	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	196					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding				0				GBM - Glioblastoma multiforme(114;0.158)		TGTAGCCCCTGGTCTCCTCAA	0.463													94	65					0	0	0	0	A	120365175	A	A	120365175	2	1	2	1	0	0	0	0	0	0	0	1	7123	1335	47	4		4	HGD	3	120365175	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	907008	120365175	77657255	39	214											
ATR	545	broad.mit.edu	37	chr3	142275364	142275364	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgttctccactcaaggaataTtcttcttggaaacagagtca	12	13	7	9	0	5	1	2	0	3	1	6	3	5	3	1	2	1	1	1	2	4	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr3:142275364T>G	uc003eux.3	-	9	2061	c.1939A>C	c.(1939-1941)ATA>CTA	p.I647L		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	647					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TCAAGGAATATTCTTCTTGGA	0.383								Other_conserved_DNA_damage_response_genes					107	184					0	0	0	0	G	142275364	G	G	142275364	3	3	2	1	0	0	0	0	1	0	0	0	1206	1493	52	5	6151	5	ATR	3	142275364	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	21910189	142275364	55747066	40	215											
SI	6476	broad.mit.edu	37	chr3	164772993	164772994	+	Nonsense_Mutation	DNP	CA	AT	AT																															gctacttacaatccaaagtcCatcatattgcacttcttgat																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr3:164772993_164772994CA>AT	uc003fei.2	-	13	1562_1563	c.1500_1501TG>AT	c.(1498-1503)GATGGA>GAATGA	p.500_501DG>E*		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	500_501	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATCCAAAGTCCATCATATTGCA	0.327										HNSCC(35;0.089)			8	203					0	0	0	0	AT	164772994	AT	AT	164772993	4	1	2	1	0	0	0	0	0	1	0	0	14362	603	21	4	4126	4	SI	3	164772993	Nonsense_Mutation	DNP	CA	TCGA-BA-4075-01A-01D-1434-08	22497629	164772993	33249437	41	216											
RTP2	344892	broad.mit.edu	37	chr3	187416695	187416695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcacagctgcttgaagacgCgcatgcgcaccgagcccgcc	9	4	12	16	5	0	2	0	1	0	1	0	3	0	2	3	0	5	5	3	0	1	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr3:187416695C>T	uc003fro.1	-	2	698	c.269G>A	c.(268-270)CGC>CAC	p.R90H		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	90	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		CTTGAAGACGCGCATGCGCAC	0.647													21	43					0	0	0	0	T	187416695	T	T	187416695	3	4	2	1	0	0	0	0	1	0	0	0	13799	768	27	1	412	1	RTP2	3	187416695	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	22643702	187416695	10605735	42	217											
C3orf21	152002	broad.mit.edu	37	chr3	194790731	194790731	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcggggactggcgcatggCctccaggttcagcaacatca	9	6	14	12	2	2	0	2	0	0	0	3	2	3	1	2	5	3	3	2	5	1	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr3:194790731C>A	uc003fum.3	-	4	1003	c.895G>T	c.(895-897)GCC>TCC	p.A299S	C3orf21_uc003ful.2_Missense_Mutation_p.A96S|C3orf21_uc003fuk.2_Missense_Mutation_p.A93S	NM_152531	NP_689744	Q8NBI6	CC021_HUMAN	hypothetical protein LOC152002	299						integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)		TGGCGCATGGCCTCCAGGTTC	0.706													10	119					2.17888e-05	2.41875e-05	1	0	A	194790731	A	A	194790731	3	1	2	1	0	0	0	0	1	0	0	0	2224	739	26	4	290	4	C3orf21	3	194790731	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	7374036	194790731	3231699	43	218											
WDR1	9948	broad.mit.edu	37	chr4	10083023	10083023	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgtatcccccggggccgacGgctacgcactttggctgaac	6	7	13	15	5	0	1	0	1	0	0	1	2	1	1	3	4	2	4	3	4	3	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr4:10083023G>A	uc003gmf.2	-	11	1525	c.1242C>T	c.(1240-1242)GCC>GCT	p.A414A	WDR1_uc003gmg.2_Silent_p.A274A|WDR1_uc010idm.2_RNA|hsa-mir-3138|MI0014161_5'Flank	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	414					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CGGGGCCGACGGCTACGCACT	0.572													3	70					0	0	0	0	A	10083023	A	A	10083023	2	1	2	1	0	0	0	0	0	0	0	1	17340	1103	39	1		1	WDR1	4	10083023	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08		10083023	181071253	44	219											
BST1	683	broad.mit.edu	37	chr4	15709251	15709251	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagatttcttgagctggtgtCgacagaaaaatgactctggt	11	12	11	7	1	2	4	0	2	2	2	3	5	2	4	0	2	1	1	0	2	2	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr4:15709251C>G	uc003goh.3	+	3	628	c.433C>G	c.(433-435)CGA>GGA	p.R145G		NM_004334	NP_004325	Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1 precursor	145					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)	1						GAGCTGGTGTCGACAGAAAAA	0.358													54	115					0	0	0	0	G	15709251	G	G	15709251	3	3	2	1	0	0	0	0	1	0	0	0	1538	876	31	3	443	3	BST1	4	15709251	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	5626228	15709251	175445025	45	220											
YIPF7	285525	broad.mit.edu	37	chr4	44631497	44631497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcattcataatgctgccatCtactggcttcattgggttta	8	17	7	9	0	4	0	3	0	1	0	4	0	4	0	1	2	3	3	1	2	3	8			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr4:44631497C>T	uc010ifx.1	-	4	438	c.421G>A	c.(421-423)GAT>AAT	p.D141N	YIPF7_uc010ify.1_3'UTR	NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	141						endoplasmic reticulum membrane|integral to membrane					0						ATGCTGCCATCTACTGGCTTC	0.403													3	9					0	0	0	0	T	44631497	T	T	44631497	3	4	2	1	0	0	0	0	1	0	0	0	17551	913	32	2	433	2	YIPF7	4	44631497	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	28922246	44631497	146522779	46	221											
UGT2B4	7363	broad.mit.edu	37	chr4	70360946	70360946	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagcacatagatcatattttTtaccctctctatgaaagtca	14	14	4	9	0	3	2	2	1	1	1	4	2	3	2	1	0	2	1	1	0	6	6			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr4:70360946T>C	uc003hek.3	-	1	681	c.634A>G	c.(634-636)AAA>GAA	p.K212E	UGT2B4_uc011cap.1_Missense_Mutation_p.K76E|UGT2B4_uc003hel.3_Missense_Mutation_p.K212E	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	212					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						ATCATATTTTTTACCCTCTCT	0.363													19	52					0	0	0	0	C	70360946	C	C	70360946	3	2	2	1	0	0	0	0	1	0	0	0	17029	1850	64	5	976	5	UGT2B4	4	70360946	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	25729449	70360946	120793330	47	222											
GK2	2712	broad.mit.edu	37	chr4	80328069	80328069	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcataagaactttgttgttgGtcattcctccatctacctgc	8	15	7	11	0	2	1	1	0	1	1	4	1	4	1	3	1	3	3	3	1	3	6			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr4:80328069G>T	uc003hlu.2	-	1	1304	c.1286C>A	c.(1285-1287)ACC>AAC	p.T429N		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	429	ATP (By similarity).				glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						TTTGTTGTTGGTCATTCCTCC	0.428													45	103					1.76056e-25	2.09879e-25	1	0	T	80328069	T	T	80328069	3	4	2	1	0	0	0	0	1	0	0	0	6458	1261	44	4	379	4	GK2	4	80328069	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	9967123	80328069	110826207	48	223											
EGF	1950	broad.mit.edu	37	chr4	110890205	110890205	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcgagaaaggcttattgagGaaggagtagatgtgccagaa	15	7	15	4	1	0	4	0	1	0	3	0	7	0	6	1	3	2	2	1	3	5	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr4:110890205G>T	uc003hzy.3	+	11	2106	c.1654G>T	c.(1654-1656)GAA>TAA	p.E552*	EGF_uc011cfu.1_Nonsense_Mutation_p.E510*|EGF_uc011cfv.1_Nonsense_Mutation_p.E552*	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	552	LDL-receptor class B 6.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GCTTATTGAGGAAGGAGTAGA	0.453													7	105					0.00198382	0.00206933	1	0	T	110890205	T	T	110890205	4	4	2	1	0	0	0	0	0	1	0	0	4984	1175	41	2	1696	2	EGF	4	110890205	Nonsense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	30562136	110890205	80264071	49	224											
ACCN5	51802	broad.mit.edu	37	chr4	156751052	156751052	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atttcccagatgattctgagGtggaggagtccactgggtca	9	11	13	8	0	2	3	1	2	1	1	4	5	4	5	2	4	0	0	2	4	0	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr4:156751052G>T	uc003ipe.1	-	10	1521	c.1474C>A	c.(1474-1476)CCT>ACT	p.P492T		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	492	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		TGATTCTGAGGTGGAGGAGTC	0.338													5	62					0.00116845	0.00124019	1	0	T	156751052	T	T	156751052	3	4	2	1	0	0	0	0	1	0	0	0	132	1261	44	4	47	4	ACCN5	4	156751052	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	45860847	156751052	34403224	50	225											
FAT1	2195	broad.mit.edu	37	chr4	187542087	187542088	+	Frame_Shift_Ins	INS	-	A	A																															ggtaacaaaagagatgcttcINSatataatggcttggcaaaca																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr4:187542087_187542088insA	uc003izf.2	-	10	5840_5841	c.5652_5653insT	c.(5650-5655)TATGAAfs	p.Y1884fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1884_1885	Extracellular (Potential).|Cadherin 17.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AGAGATGCTTCATATAATGGCT	0.396										HNSCC(5;0.00058)			---	---	---								A	187542088	A	A	187542087	7	5	2	1	0	1	1	0	0	0	0	0	5721	835	29	0	8185	0	FAT1	4	187542087	Frame_Shift_Ins	INS	-	TCGA-BA-4075-01A-01D-1434-08	30791035	187542087	3612189	51	226											
ZDHHC11	79844	broad.mit.edu	37	chr5	825360	825360	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcagcagggagctcttggcTttgactctggtgggacagaa	9	10	14	8	0	3	2	1	1	2	1	3	4	3	4	0	4	2	3	0	4	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:825360T>C	uc011cma.1	-	8	1326	c.942A>G	c.(940-942)AAA>AAG	p.K314K	ZDHHC11_uc010itc.2_5'Flank|ZDHHC11_uc003jbj.2_RNA|ZDHHC11_uc010itd.1_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	314						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			AGCTCTTGGCTTTGACTCTGG	0.552													13	186					0	0	0	0	C	825360	C	C	825360	2	2	2	1	0	0	0	0	0	0	0	1	17668	1606	56	5		5	ZDHHC11	5	825360	Silent	SNP	T	TCGA-BA-4075-01A-01D-1434-08		825360	180089900	52	227											
SLC6A18	348932	broad.mit.edu	37	chr5	1246007	1246007	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctctacccgggctgggcGcgcgccgcctgtgtgctgct	3	8	15	15	5	1	0	0	0	1	0	1	0	1	0	3	2	4	4	3	2	2	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:1246007G>A	uc003jby.1	+	12	1824	c.1701G>A	c.(1699-1701)GCG>GCA	p.A567A		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	567	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CGGGCTGGGCGCGCGCCGCCT	0.716													4	60					0	0	0	0	A	1246007	A	A	1246007	2	1	2	1	0	0	0	0	0	0	0	1	14745	1074	38	1		1	SLC6A18	5	1246007	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	420647	1246007	179669253	53	228											
CLPTM1L	81037	broad.mit.edu	37	chr5	1321749	1321749	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcaccggctgtcacactcaCcttgtaggtgaaggccttcc	7	10	9	15	1	3	1	3	1	0	0	4	1	4	1	4	3	0	2	4	3	2	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:1321749C>A	uc003jch.2	-	15	1462	c.1416_splice	c.e15+1	p.K472_splice	CLPTM1L_uc003jcg.2_Splice_Site_p.K303_splice	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	CLPTM1-like						apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		GTCACACTCACCTTGTAGGTG	0.592													5	129					5.9392e-07	6.77965e-07	1	0	A	1321749	A	A	1321749	5	1	2	1	0	0	0	0	0	0	1	0	3570	521	18	4	211	4	CLPTM1L	5	1321749	Splice_Site	SNP	C	TCGA-BA-4075-01A-01D-1434-08	75742	1321749	179593511	54	229											
LPCAT1	79888	broad.mit.edu	37	chr5	1488528	1488528	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtttgaaggtaattaggcaGgtcctgtttgtacaagttcc	9	14	12	6	0	0	1	0	1	0	0	2	1	2	1	2	4	1	6	2	4	5	6			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:1488528G>A	uc003jcm.2	-	5	762	c.645C>T	c.(643-645)ACC>ACT	p.T215T		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	215	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		TAATTAGGCAGGTCCTGTTTG	0.303													7	201					0	0	0	0	A	1488528	A	A	1488528	2	1	2	1	0	0	0	0	0	0	0	1	8960	987	35	4		4	LPCAT1	5	1488528	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	166779	1488528	179426732	55	230											
TARS	6897	broad.mit.edu	37	chr5	33455798	33455798	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttaagaaagaaactttactgGcaatgtttaaggtaaattga	17	13	8	3	0	0	3	0	1	0	2	0	3	0	3	0	2	2	3	0	2	8	7			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:33455798G>A	uc003jhy.2	+	6	977	c.682G>A	c.(682-684)GCA>ACA	p.A228T	TARS_uc011cob.1_Missense_Mutation_p.A216T|TARS_uc010iup.1_Missense_Mutation_p.A169T|TARS_uc011coc.1_Missense_Mutation_p.A249T|TARS_uc003jhz.2_Missense_Mutation_p.A124T|TARS_uc011cod.1_Missense_Mutation_p.A107T	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	228					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	AACTTTACTGGCAATGTTTAA	0.373													16	195					0	0	0	0	A	33455798	A	A	33455798	3	1	2	1	0	0	0	0	1	0	0	0	15625	1203	42	4	704	4	TARS	5	33455798	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	31967270	33455798	147459462	56	231											
ERBB2IP	55914	broad.mit.edu	37	chr5	65349867	65349867	+	Frame_Shift_Del	DEL	A	-	-																															atcacatctgctgttgatggAaaaaatatagtcaggagcaa																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:65349867delA	uc003juk.1	+	21	3029	c.2721delA	c.(2719-2721)GGAfs	p.G907fs	ERBB2IP_uc003jui.1_Frame_Shift_Del_p.G907fs|ERBB2IP_uc003juj.1_Frame_Shift_Del_p.G907fs|ERBB2IP_uc011cqx.1_Frame_Shift_Del_p.G907fs|ERBB2IP_uc011cqy.1_Frame_Shift_Del_p.G907fs|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Frame_Shift_Del_p.G903fs|ERBB2IP_uc003jul.1_Frame_Shift_Del_p.G903fs	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	907					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		CTGTTGATGGAAAAAATATAG	0.378													---	---	---								-	65349867	-	-	65349867	7	5	2	1	0	1	0	1	0	0	0	0	5231	233	9	0	2795	0	ERBB2IP	5	65349867	Frame_Shift_Del	DEL	A	TCGA-BA-4075-01A-01D-1434-08	31894069	65349867	115565393	57	232											
TNPO1	3842	broad.mit.edu	37	chr5	72187641	72187641	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatcattgtaaataggaatAtattcagatgctaatgcctc	14	14	6	7	0	3	1	3	0	0	1	4	2	3	2	1	1	2	2	1	1	7	7			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:72187641A>G	uc003kck.3	+	15	1853	c.1706A>G	c.(1705-1707)TAT>TGT	p.Y569C	TNPO1_uc011csj.1_Missense_Mutation_p.Y519C|TNPO1_uc003kch.2_Missense_Mutation_p.Y561C|TNPO1_uc003kci.3_Missense_Mutation_p.Y561C|TNPO1_uc003kcg.3_Missense_Mutation_p.Y561C	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	569	HEAT 7.				interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		AAATAGGAATATATTCAGATG	0.328													48	114					0	0	0	0	G	72187641	G	G	72187641	3	3	2	1	0	0	0	0	1	0	0	0	16401	449	16	5	1764	5	TNPO1	5	72187641	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	6837774	72187641	108727619	58	233											
SIL1	64374	broad.mit.edu	37	chr5	138356974	138356974	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggaaagcaggtcctgcgcaTtgtccatctgcaacagagcc	11	7	11	12	1	1	1	0	0	1	1	3	2	3	2	3	2	5	3	3	2	2	1	rs150156151		TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:138356974T>C	uc003ldm.2	-	6	670	c.653A>G	c.(652-654)AAT>AGT	p.N218S	SIL1_uc003ldn.2_Missense_Mutation_p.N217S|SIL1_uc003ldo.2_Missense_Mutation_p.N218S|SIL1_uc003ldp.2_Missense_Mutation_p.N218S|SIL1_uc003ldq.1_Missense_Mutation_p.N11S	NM_022464	NP_071909	Q9H173	SIL1_HUMAN	SIL1 protein precursor	218	Interaction with HSPA5 and localization to the endoplasmic reticulum (By similarity).				intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTCCTGCGCATTGTCCATCTG	0.502									Marinesco-Sj_gren_syndrome				20	35					0	0	0	0	C	138356974	C	C	138356974	3	2	2	1	0	0	0	0	1	0	0	0	14386	1493	52	5	748	5	SIL1	5	138356974	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	66169333	138356974	42558286	59	234											
PCDHA11	56138	broad.mit.edu	37	chr5	140250178	140250178	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctactcgctggtggagcggcGgttgggcgaccgcgcgctgt	3	8	18	12	7	0	0	0	0	0	0	1	2	0	1	1	5	2	3	1	5	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:140250178G>A	uc003lia.2	+	1	2348	c.1490G>A	c.(1489-1491)CGG>CAG	p.R497Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R497Q	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	497	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGAGCGGCGGTTGGGCGAC	0.672													16	119					0	0	0	0	A	140250178	A	A	140250178	3	1	2	1	0	0	0	0	1	0	0	0	11575	1116	39	1	1492	1	PCDHA11	5	140250178	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	1893204	140250178	40665082	60	235											
PCDHGB5	56101	broad.mit.edu	37	chr5	140779207	140779207	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcttacgtgtccatgagcGcgcaaagtggggtggtgttc	6	11	14	10	3	1	1	0	1	1	0	3	1	2	1	2	3	2	2	2	3	2	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:140779207G>A	uc003lkf.1	+	1	1513	c.1513G>A	c.(1513-1515)GCG>ACG	p.A505T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.A505T	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	505	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCATGAGCGCGCAAAGTGG	0.632													3	36					0	0	0	0	A	140779207	A	A	140779207	3	1	2	1	0	0	0	0	1	0	0	0	11620	1087	38	1	1515	1	PCDHGB5	5	140779207	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	529029	140779207	40136053	61	236											
ARAP3	64411	broad.mit.edu	37	chr5	141041799	141041799	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcacgagcgccccctttccGgtatacaccttccagccgga	7	7	10	17	4	0	0	0	0	0	0	2	2	2	1	6	3	3	2	6	3	2	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:141041799G>A	uc003llm.2	-	20	2902	c.2824C>T	c.(2824-2826)CGG>TGG	p.R942W	ARAP3_uc003lll.2_5'UTR|ARAP3_uc011dbe.1_Missense_Mutation_p.R604W|ARAP3_uc003lln.2_Intron	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	942	Rho-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CCCCCTTTCCGGTATACACCT	0.657													38	88					0	0	0	0	A	141041799	A	A	141041799	3	1	2	1	0	0	0	0	1	0	0	0	840	1115	39	1	1866	1	ARAP3	5	141041799	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	262592	141041799	39873461	62	237											
RNF14	9604	broad.mit.edu	37	chr5	141358230	141358230	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgttcctgtgcagtatctgTttctgtgagaagctgggtag	6	16	13	6	0	2	1	0	1	2	1	3	2	3	1	1	1	2	6	1	1	3	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:141358230T>C	uc003lly.2	+	4	708	c.669T>C	c.(667-669)TGT>TGC	p.C223C	RNF14_uc003llz.2_Silent_p.C223C|RNF14_uc003lma.2_Silent_p.C223C|RNF14_uc003lmb.2_Silent_p.C97C|RNF14_uc003lmc.2_Silent_p.C223C|RNF14_uc011dbg.1_Intron|RNF14_uc011dbh.1_Intron|RNF14_uc003lmd.2_Silent_p.C223C	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	223	RING-type 1; atypical.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GCAGTATCTGTTTCTGTGAGA	0.413													50	93					0	0	0	0	C	141358230	C	C	141358230	2	2	2	1	0	0	0	0	0	0	0	1	13508	1731	60	5		5	RNF14	5	141358230	Silent	SNP	T	TCGA-BA-4075-01A-01D-1434-08	316431	141358230	39557030	63	238											
FAM153B	202134	broad.mit.edu	37	chr5	175540969	175540989	+	In_Frame_Del	DEL	AAGCCCAAGAAGAAAACCAGG	-	-																															gtcccatcaggaaaaccagaAagcccaagaagaaaaccagg																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr5:175540969_175540989delAAGCCCAAGAAGAAAACCAGG	uc003mdk.2	+	21	1138_1158	c.1081_1101delAAGCCCAAGAAGAAAACCAGG	c.(1081-1101)AAGCCCAAGAAGAAAACCAGGdel	p.KPKKKTR361del		NM_001079529	NP_001072997	P0C7A2	F153B_HUMAN	hypothetical protein LOC202134	361_367										ovary(1)	1	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		GAAAACCAGAAAGCCCAAGAAGAAAACCAGGAAGCCCAGCA	0.471													---	---	---								-	175540989	-	-	175540969	7	5	2	1	0	1	0	1	0	0	0	0	5489	15	1	0	1163	0	FAM153B	5	175540969	In_Frame_Del	DEL	AAGCCCAAGAAGAAAACCAGG	TCGA-BA-4075-01A-01D-1434-08	34182739	175540969	5374291	64	239											
GCM2	9247	broad.mit.edu	37	chr6	10874289	10874289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtctgagtaactgactgcgGagcccagcccagacagacac	11	6	11	13	1	1	4	0	2	1	2	1	5	1	5	2	1	4	1	2	1	1	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr6:10874289G>A	uc003mzn.3	-	5	1532	c.1460C>T	c.(1459-1461)TCC>TTC	p.S487F	SYCP2L_uc011dim.1_Intron	NM_004752	NP_004743	O75603	GCM2_HUMAN	glial cells missing homolog 2	487					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				ACTGACTGCGGAGCCCAGCCC	0.522													10	128					0	0	0	0	A	10874289	A	A	10874289	3	1	2	1	0	0	0	0	1	0	0	0	6333	1174	41	2	64	2	GCM2	6	10874289	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08		10874289	160240778	65	240											
BTN3A2	11118	broad.mit.edu	37	chr6	26370583	26370583	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcttcacgtcgaagtgaaggGttatgaggatggagggatcc	10	10	15	6	2	2	2	1	2	1	0	4	6	3	5	1	4	0	1	1	4	3	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr6:26370583G>T	uc010jqh.1	+	5	726	c.467G>T	c.(466-468)GGT>GTT	p.G156V	BTN3A2_uc003nho.1_Missense_Mutation_p.G154V|BTN3A2_uc003nhp.2_Missense_Mutation_p.G156V|BTN3A2_uc011dkd.1_Missense_Mutation_p.G114V|BTN3A2_uc011dke.1_Missense_Mutation_p.G133V|BTN3A2_uc010jqi.1_Missense_Mutation_p.G154V	NM_007047	NP_008978	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2 precursor	156	Extracellular (Potential).					integral to membrane					0						GAAGTGAAGGGTTATGAGGAT	0.453													7	146					2.7689e-08	3.1757e-08	1	0	T	26370583	T	T	26370583	3	4	2	1	0	0	0	0	1	0	0	0	1568	1261	44	4	477	4	BTN3A2	6	26370583	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	15496294	26370583	144744484	66	241											
HLA-DQB1	3119	broad.mit.edu	37	chr6	32632675	32632675	+	Frame_Shift_Del	DEL	C	-	-																															aggacttccttctggctgttCcagtactcggcatcaggccg																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr6:32632675delC	uc003obw.2	-	2	361	c.279delG	c.(277-279)TGGfs	p.W93fs	HLA-DQB1_uc010juc.1_Frame_Shift_Del_p.W48fs|HLA-DQB1_uc003obv.2_Frame_Shift_Del_p.W93fs|HLA-DQB1_uc011dqd.1_Frame_Shift_Del_p.W93fs|HLA-DQB1_uc011dqe.1_Frame_Shift_Del_p.W93fs	NM_002123	NP_002114	P01920	DQB1_HUMAN	major histocompatibility complex, class II, DQ	93	Extracellular (Potential).|Beta-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTGGCTGTTCCAGTACTCGG	0.637									Melanoma_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia|T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Sj_gren_syndrome				---	---	---								-	32632675	-	-	32632675	7	5	2	1	0	1	0	1	0	0	0	0	7245	856	30	0	522	0	HLA-DQB1	6	32632675	Frame_Shift_Del	DEL	C	TCGA-BA-4075-01A-01D-1434-08	6262092	32632675	138482392	67	242											
HLA-DQA2	3118	broad.mit.edu	37	chr6	32713716	32713716	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcacagaaggtgtttctgaGaccagcttcctctccaagag	10	10	10	11	0	3	3	1	1	2	3	5	4	4	3	3	1	1	2	3	1	2	2	rs35633399		TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr6:32713716G>C	uc003obx.2	+	3	538	c.480G>C	c.(478-480)GAG>GAC	p.E160D		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	160	Alpha-2.|Extracellular (Potential).|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GTGTTTCTGAGACCAGCTTCC	0.493													8	376					0	0	0	0	C	32713716	C	C	32713716	3	2	2	1	0	0	0	0	1	0	0	0	7244	933	33	2	490	2	HLA-DQA2	6	32713716	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	81041	32713716	138401351	68	243											
SASH1	23328	broad.mit.edu	37	chr6	148865297	148865297	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcattgctactgacccaaagCaagagattttctgaacctca	13	10	7	11	0	2	3	1	2	1	1	2	4	2	3	2	0	4	3	2	0	4	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr6:148865297C>T	uc003qme.1	+	18	3166	c.2691C>T	c.(2689-2691)AGC>AGT	p.S897S	SASH1_uc011eeb.1_Silent_p.S658S|SASH1_uc003qmf.1_Silent_p.S307S	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	897							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		TGACCCAAAGCAAGAGATTTT	0.537													9	271					0	0	0	0	T	148865297	T	T	148865297	2	4	2	1	0	0	0	0	0	0	0	1	13913	709	25	4		4	SASH1	6	148865297	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	116151581	148865297	22249770	69	244											
SYNE1	23345	broad.mit.edu	37	chr6	152523002	152523002	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagctcttcatggtgatccGggagagactgcgaaagcttc	9	9	14	9	2	2	2	1	1	1	1	4	6	3	4	1	3	3	2	1	3	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr6:152523002G>A	uc010kiw.2	-	127	23704	c.23102C>T	c.(23101-23103)CCG>CTG	p.P7701L	SYNE1_uc010kiv.2_Missense_Mutation_p.P2225L|SYNE1_uc003qos.3_Missense_Mutation_p.P2225L|SYNE1_uc003qot.3_Missense_Mutation_p.P7630L|SYNE1_uc003qou.3_Missense_Mutation_p.P7701L|SYNE1_uc003qor.3_Missense_Mutation_p.P601L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7701	Cytoplasmic (Potential).|Spectrin 26.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGGTGATCCGGGAGAGACTG	0.433										HNSCC(10;0.0054)			12	99					0	0	0	0	A	152523002	A	A	152523002	3	1	2	1	0	0	0	0	1	0	0	0	15511	1116	39	1	3444	1	SYNE1	6	152523002	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	3657705	152523002	18592065	70	245											
CARD11	84433	broad.mit.edu	37	chr7	2956977	2956977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgagagacgggggctgacccGggggtcgcttgttgaaagcg	7	6	19	9	5	0	3	0	2	0	1	1	5	0	3	1	4	1	3	1	4	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:2956977G>A	uc003smv.2	-	20	3054	c.2650C>T	c.(2650-2652)CGG>TGG	p.R884W		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	884					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGGCTGACCCGGGGGTCGCTT	0.547			Mis		DLBCL								11	63					0	0	0	0	A	2956977	A	A	2956977	3	1	2	1	0	0	0	0	1	0	0	0	2657	1115	39	1	838	1	CARD11	7	2956977	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08		2956977	156181686	71	246											
OCM	654231	broad.mit.edu	37	chr7	5920406	5920406	+	5'Flank	DEL	T	-	-																															tcttaatttaaaaaaaaaaaTaatctagacacacatacagt																								rs10235465		TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:5920406delT	uc003spe.3	+							NM_001097622	NP_001091091	P0CE72	ONCO_HUMAN	oncomodulin								calcium ion binding				0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		aaaaaaaaaaTAATCTAGACA	0.229													---	---	---								-	5920406	-	-	5920406	6	5	2	0	1	1	0	1	0	0	0	0	10875	1421	49	0		0	OCM	7	5920406	5'Flank	DEL	T	TCGA-BA-4075-01A-01D-1434-08	2963429	5920406	153218257	72	247											
C1GALT1	56913	broad.mit.edu	37	chr7	7278537	7278537	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttggtactggaattacaactAttatcctcctgtagaggtaa	12	14	8	7	0	0	1	0	0	0	1	2	2	2	2	2	3	3	3	2	3	8	7			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:7278537A>G	uc010ktn.2	+	3	1095	c.872A>G	c.(871-873)TAT>TGT	p.Y291C	C1GALT1_uc003sra.2_Missense_Mutation_p.Y291C|C1GALT1_uc010kto.1_Missense_Mutation_p.Y291C	NM_020156	NP_064541	Q9NS00	C1GLT_HUMAN	core 1 synthase,	291	Lumenal (Potential).				angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		AATTACAACTATTATCCTCCT	0.313													107	50					0	0	0	0	G	7278537	G	G	7278537	3	3	2	1	0	0	0	0	1	0	0	0	1961	449	16	5	878	5	C1GALT1	7	7278537	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	1358131	7278537	151860126	73	248											
NOD1	10392	broad.mit.edu	37	chr7	30492295	30492295	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcctgcagacacagcctGtcactttccttgaagcagct	9	10	9	13	0	1	2	1	1	0	1	3	2	3	2	3	1	4	3	3	1	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:30492295G>A	uc003tav.2	-	6	1261	c.738C>T	c.(736-738)GAC>GAT	p.D246D	NOD1_uc010kvs.2_Missense_Mutation_p.T201I	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	246	NACHT.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						GACACAGCCTGTCACTTTCCT	0.617													12	333					0	0	0	0	A	30492295	A	A	30492295	2	1	2	1	0	0	0	0	0	0	0	1	10570	1368	48	4		4	NOD1	7	30492295	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	23213758	30492295	128646368	74	249											
SFRP4	6424	broad.mit.edu	37	chr7	37955852	37955852	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttggcacaccgacttgcaCggcttgatagggtcgtgcag	7	9	14	11	4	0	1	0	1	0	0	1	2	0	1	1	3	2	5	1	3	1	4	rs143563677		TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:37955852C>T	uc003tfo.3	-	1	674	c.288G>A	c.(286-288)CCG>CCA	p.P96P		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	96	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						CCGACTTGCACGGCTTGATAG	0.632													10	90					0	0	0	0	T	37955852	T	T	37955852	2	4	2	1	0	0	0	0	0	0	0	1	14228	523	19	1		1	SFRP4	7	37955852	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	7463557	37955852	121182811	75	250											
C7orf10	79783	broad.mit.edu	37	chr7	40498705	40498705	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttttttcttttagatcttGgatttgcctgagttgattga	7	22	8	4	0	2	4	0	3	2	1	2	5	2	5	1	1	1	1	1	1	1	9			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:40498705G>T	uc003thn.1	+	11	939	c.894G>T	c.(892-894)TTG>TTT	p.L298F	C7orf10_uc003thm.1_Missense_Mutation_p.L268F|C7orf10_uc003tho.1_Missense_Mutation_p.L250F	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	305							transferase activity			ovary(2)	2						TTTAGATCTTGGATTTGCCTG	0.348													35	99					9.17885e-22	1.08886e-21	1	0	T	40498705	T	T	40498705	3	4	2	1	0	0	0	0	1	0	0	0	2387	1339	47	4	846	4	C7orf10	7	40498705	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	2542853	40498705	118639958	76	251											
PKD1L1	168507	broad.mit.edu	37	chr7	47933651	47933651	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaccacactgccttcaatCtgaacctgcaggggcaagga	12	7	9	13	0	2	1	1	1	1	0	2	2	2	2	3	3	4	2	3	3	4	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:47933651C>A	uc003tny.1	-	15	2277	c.2277G>T	c.(2275-2277)CAG>CAT	p.Q759H		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	759	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TGCCTTCAATCTGAACCTGCA	0.547													23	183					2.89027e-11	3.37896e-11	1	0	A	47933651	A	A	47933651	3	1	2	1	0	0	0	0	1	0	0	0	12019	912	32	2	6444	2	PKD1L1	7	47933651	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	7434946	47933651	111205012	77	252											
EGFR	1956	broad.mit.edu	37	chr7	55231431	55231431	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcctcctctcagtgagcCaagggagtttgtggagaact	8	12	11	10	0	2	2	1	1	2	1	5	4	4	3	3	2	2	1	3	2	2	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:55231431C>A	uc003tqk.2	+	14	1883	c.1637C>A	c.(1636-1638)CCA>CAA	p.P546Q	EGFR_uc003tqi.2_Missense_Mutation_p.P546Q|EGFR_uc003tqj.2_Missense_Mutation_p.P546Q|EGFR_uc010kzg.1_Missense_Mutation_p.P501Q|EGFR_uc011kco.1_Missense_Mutation_p.P493Q|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_Intron|EGFR_uc003tqn.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	546	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTCAGTGAGCCAAGGGAGTTT	0.517		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			13	310					4.36969e-10	5.05964e-10	1	0	A	55231431	A	A	55231431	3	1	2	1	0	0	0	0	1	0	0	0	4989	594	21	4	1702	4	EGFR	7	55231431	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	7297780	55231431	103907232	78	253											
PCLO	27445	broad.mit.edu	37	chr7	82584021	82584021	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cctcaccaatgggggcctggGttgggctagatccaggtgtt	6	10	15	10	0	1	1	1	0	0	1	2	1	2	1	4	5	0	3	4	5	2	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:82584021G>T	uc003uhx.2	-	5	6537	c.6248C>A	c.(6247-6249)ACC>AAC	p.T2083N	PCLO_uc003uhv.2_Missense_Mutation_p.T2083N	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2014					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGGGGCCTGGGTTGGGCTAGA	0.463													6	117					0.00116845	0.00124019	1	0	T	82584021	T	T	82584021	3	4	2	1	0	0	0	0	1	0	0	0	11637	1261	44	4	9281	4	PCLO	7	82584021	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	27352590	82584021	76554642	79	254											
FZD1	8321	broad.mit.edu	37	chr7	90894572	90894572	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccatcccgctgtgcacggAcatcgcgtacaaccagacca	10	6	8	17	4	0	1	0	0	0	1	3	2	2	2	4	1	3	3	4	1	2	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:90894572A>T	uc003ula.2	+	1	790	c.377A>T	c.(376-378)GAC>GTC	p.D126V		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	126	FZ.|Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CTGTGCACGGACATCGCGTAC	0.632													17	84					0	0	0	0	T	90894572	T	T	90894572	3	4	2	1	0	0	0	0	1	0	0	0	6162	275	10	5	379	5	FZD1	7	90894572	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	8310551	90894572	68244091	80	255											
COPG2	26958	broad.mit.edu	37	chr7	130295823	130295824	+	Splice_Site	DNP	CC	AA	AA																															ggtttaggtgaagacacttaCccatcctcagtttcttttag																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:130295823_130295824CC>AA	uc003vqh.1	-	10	2236	c.2146_splice	c.e10-1	p.A716_splice		NM_012133	NP_036265	Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2						intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity				0	Melanoma(18;0.0435)					AAGACACTTACCCATCCTCAGT	0.366													6	123					0	0	0	0	AA	130295824	AA	AA	130295823	5	1	2	1	0	0	0	0	0	0	1	0	3747	521	18	4	488	4	COPG2	7	130295823	Splice_Site	DNP	CC	TCGA-BA-4075-01A-01D-1434-08	39401251	130295823	28842840	81	256											
WDR91	29062	broad.mit.edu	37	chr7	134889075	134889075	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggttgaggagggccctgaGcaggcgacaaccttgagggg	9	5	19	8	1	0	3	0	3	0	0	0	6	0	4	2	6	2	2	2	6	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:134889075G>A	uc003vsp.2	-	6	898	c.836C>T	c.(835-837)GCT>GTT	p.A279V	WDR91_uc010lmq.2_5'UTR|WDR91_uc010lmr.2_RNA	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	279										breast(2)|ovary(1)|skin(1)	4						AGGGCCCTGAGCAGGCGACAA	0.592													7	92					0	0	0	0	A	134889075	A	A	134889075	3	1	2	1	0	0	0	0	1	0	0	0	17406	971	34	4	1447	4	WDR91	7	134889075	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	4593252	134889075	24249588	82	257											
TRPV5	56302	broad.mit.edu	37	chr7	142630518	142630518	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggcagaagtttctggagttgGctcccgggcccttctgcctt	4	12	13	12	1	2	1	0	0	2	1	3	2	3	2	3	4	1	4	3	4	1	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:142630518G>T	uc003wby.1	-	1	303	c.39C>A	c.(37-39)AGC>AGA	p.S13R	TRPV5_uc003wbz.2_Missense_Mutation_p.S13R	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	13	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					TCTGGAGTTGGCTCCCGGGCC	0.517													10	160					3.86212e-05	4.26773e-05	1	0	T	142630518	T	T	142630518	3	4	2	1	0	0	0	0	1	0	0	0	16666	1194	42	4	2210	4	TRPV5	7	142630518	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	7741443	142630518	16508145	83	258											
CNTNAP2	26047	broad.mit.edu	37	chr7	147259261	147259261	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccttcctgtgaagcctacaaAcacctaggacagacatcaaa	15	7	6	13	0	1	2	1	1	0	1	2	3	2	3	4	1	3	0	4	1	5	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:147259261A>T	uc003weu.1	+	12	2325	c.1809A>T	c.(1807-1809)AAA>AAT	p.K603N		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	603	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAGCCTACAAACACCTAGGAC	0.448										HNSCC(39;0.1)			18	113					0	0	0	0	T	147259261	T	T	147259261	3	4	2	1	0	0	0	0	1	0	0	0	3662	40	2	5	1855	5	CNTNAP2	7	147259261	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	4628743	147259261	11879402	84	259											
GIMAP6	474344	broad.mit.edu	37	chr7	150325305	150325305	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cggcccagttgtgtcaccagGagcacggcgtggggccctgg	5	6	17	13	3	1	0	1	0	0	0	1	1	1	1	3	6	1	2	3	6	0	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:150325305G>T	uc003whn.2	-	3	805	c.381C>A	c.(379-381)CTC>CTA	p.L127L	GIMAP6_uc003whm.2_Silent_p.L47L	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	127							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGTCACCAGGAGCACGGCGT	0.627													7	153					0.00198382	0.00206933	1	0	T	150325305	T	T	150325305	2	4	2	1	0	0	0	0	0	0	0	1	6420	1161	41	2		2	GIMAP6	7	150325305	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	3066044	150325305	8813358	85	260											
ABCB8	11194	broad.mit.edu	37	chr7	150737355	150737355	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctctctcctttttctgacagGtccatggccaacctctctgt	5	15	6	15	0	3	1	0	1	3	0	7	1	5	1	4	2	1	0	4	2	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr7:150737355G>T	uc003wil.3	+	11	1362	c.1269G>T	c.(1267-1269)AGG>AGT	p.R423S	ABCB8_uc010lpw.1_Intron|ABCB8_uc010lpx.2_Missense_Mutation_p.R406S|ABCB8_uc011kvd.1_Missense_Mutation_p.R318S|ABCB8_uc003wim.3_Missense_Mutation_p.R201S|ABCB8_uc003wik.3_Missense_Mutation_p.R406S	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	423	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTTCTGACAGGTCCATGGCCA	0.617													6	158					0.00116845	0.00124019	1	0	T	150737355	T	T	150737355	3	4	2	1	0	0	0	0	1	0	0	0	47	1275	44	4	1256	4	ABCB8	7	150737355	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	412050	150737355	8401308	86	261											
PSD3	23362	broad.mit.edu	37	chr8	18430163	18430163	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attgattttgtttatccaccCttgcatttcctctgggctcc	5	18	6	12	0	1	1	0	1	1	0	4	1	4	1	4	1	1	3	4	1	1	7			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr8:18430163C>T	uc003wza.2	-	14	2762	c.2659G>A	c.(2659-2661)GGG>AGG	p.G887R	PSD3_uc003wyx.3_Missense_Mutation_p.G216R|PSD3_uc003wyy.2_Missense_Mutation_p.G353R|PSD3_uc003wyz.2_Missense_Mutation_p.G188R	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	888	PH.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TTTATCCACCCTTGCATTTCC	0.428													18	279					0	0	0	0	T	18430163	T	T	18430163	3	4	2	1	0	0	0	0	1	0	0	0	12710	681	24	4	496	4	PSD3	8	18430163	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08		18430163	127933859	87	262											
LOXL2	4017	broad.mit.edu	37	chr8	23191125	23191125	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtagcgctgcttcctccgtGaggcaaacattctgcagacg	9	9	11	12	3	1	2	0	1	1	1	3	2	3	2	2	1	4	5	2	1	2	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr8:23191125G>A	uc003xdh.1	-	5	1094	c.755C>T	c.(754-756)TCA>TTA	p.S252L	uc003xdj.2_5'Flank|uc003xdi.2_5'Flank	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	252	SRCR 2.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		CTTCCTCCGTGAGGCAAACAT	0.617													6	61					0	0	0	0	A	23191125	A	A	23191125	3	1	2	1	0	0	0	0	1	0	0	0	8950	1294	45	2	1609	2	LOXL2	8	23191125	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	4760962	23191125	123172897	88	263											
ADRA1A	148	broad.mit.edu	37	chr8	26627907	26627907	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccatccgtcttggagatcCtgtagaaggtctctcttgat	7	13	10	11	2	3	3	0	1	3	2	6	4	5	3	3	2	0	1	3	2	2	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr8:26627907C>T	uc003xfh.1	-	2	1596	c.1160G>A	c.(1159-1161)AGG>AAG	p.R387K	ADRA1A_uc003xfc.1_Missense_Mutation_p.R387K|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Missense_Mutation_p.R387K|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron|ADRA1A_uc003xfg.1_Missense_Mutation_p.R387K	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	387	Cytoplasmic (By similarity).			R -> G (in Ref. 9; AAK77197).	activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	CTTGGAGATCCTGTAGAAGGT	0.562													14	274					0	0	0	0	T	26627907	T	T	26627907	3	4	2	1	0	0	0	0	1	0	0	0	334	681	24	4	535	4	ADRA1A	8	26627907	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	3436782	26627907	119736115	89	264											
PPP2CB	5516	broad.mit.edu	37	chr8	30657106	30657106	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctccactgaataatatcCtctgtctacatagtcaccca	12	12	4	13	0	4	1	1	1	3	0	6	1	5	1	3	0	1	0	3	0	5	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr8:30657106C>A	uc003xik.2	-	3	503	c.268G>T	c.(268-270)GGA>TGA	p.G90*		NM_004156	NP_004147	P62714	PP2AB_HUMAN	protein phosphatase 2, catalytic subunit, beta	90					protein dephosphorylation	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex|spindle pole	metal ion binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.095)|Kidney(114;0.114)	Vitamin E(DB00163)	GAATAATATCCTCTGTCTACA	0.343													11	253					6.42651e-13	7.58642e-13	1	0	A	30657106	A	A	30657106	4	1	2	1	0	0	0	0	0	1	0	0	12441	690	24	4	685	4	PPP2CB	8	30657106	Nonsense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	4029199	30657106	115706916	90	265											
CHD7	55636	broad.mit.edu	37	chr8	61778180	61778180	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctagccttcaaccctttcctCctgtccacaatggccccggg	6	10	7	18	1	1	0	1	0	0	0	4	0	4	0	7	2	2	0	7	2	3	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr8:61778180C>T	uc003xue.2	+	38	9159	c.8682C>T	c.(8680-8682)CTC>CTT	p.L2894L		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2894					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ACCCTTTCCTCCTGTCCACAA	0.587													26	113					0	0	0	0	T	61778180	T	T	61778180	2	4	2	1	0	0	0	0	0	0	0	1	3345	842	30	2		2	CHD7	8	61778180	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	31121074	61778180	84585842	91	266											
ZFHX4	79776	broad.mit.edu	37	chr8	77768487	77768487	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctccagtccttctcccCggaatgaacggtccatcctc	6	11	6	18	2	1	1	0	1	1	0	8	2	6	2	7	2	1	0	7	2	2	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr8:77768487C>T	uc003yav.2	+	10	9582	c.9195C>T	c.(9193-9195)CCC>CCT	p.P3065P	ZFHX4_uc003yau.1_Silent_p.P3110P|ZFHX4_uc003yaw.1_Silent_p.P3065P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3065	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCCTTCTCCCCGGAATGAACG	0.527										HNSCC(33;0.089)			10	97					0	0	0	0	T	77768487	T	T	77768487	2	4	2	1	0	0	0	0	0	0	0	1	17702	639	23	1		1	ZFHX4	8	77768487	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	15990307	77768487	68595535	92	267											
C8orf59	401466	broad.mit.edu	37	chr8	86127184	86127184	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaggttcaagtgaaatgcttTttgcgaaatgtgcaagttcc	11	13	11	6	1	1	1	1	1	0	0	2	3	2	1	1	1	3	4	1	1	4	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr8:86127184T>A	uc010mac.1	-	4	437	c.197A>T	c.(196-198)AAA>ATA	p.K66I	C8orf59_uc003ydd.2_Missense_Mutation_p.K66I|C8orf59_uc010mad.1_Missense_Mutation_p.K66I|C8orf59_uc003yde.2_Missense_Mutation_p.K66I|uc003ydc.1_RNA|C8orf59_uc011lfu.1_Intron	NM_001099670	NP_001093140	Q8N0T1	CH059_HUMAN	hypothetical protein LOC401466	66											0						TGAAATGCTTTTTGCGAAATG	0.294													9	31					0	0	0	0	A	86127184	A	A	86127184	3	1	2	1	0	0	0	0	1	0	0	0	2446	1841	64	5	107	5	C8orf59	8	86127184	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	8358697	86127184	60236838	93	268											
VPS13B	157680	broad.mit.edu	37	chr8	100155309	100155309	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtcctcttgattttcgtttgGatagcagtgcggtgcatagg	6	15	13	7	2	1	1	0	1	1	0	3	2	2	2	1	3	3	3	1	3	2	6			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr8:100155309G>C	uc003yiv.2	+	13	1870	c.1759G>C	c.(1759-1761)GAT>CAT	p.D587H	VPS13B_uc003yiw.2_Missense_Mutation_p.D587H|VPS13B_uc003yit.2_Missense_Mutation_p.D587H|VPS13B_uc003yiu.1_Missense_Mutation_p.D587H|VPS13B_uc003yix.1_Missense_Mutation_p.D58H	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	587					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTTTCGTTTGGATAGCAGTGC	0.388													10	266					0	0	0	0	C	100155309	C	C	100155309	3	2	2	1	0	0	0	0	1	0	0	0	17258	1174	41	2	1847	2	VPS13B	8	100155309	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	14028125	100155309	46208713	94	269											
KCNV2	169522	broad.mit.edu	37	chr9	2719000	2719000	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgctgctcttcatcgccatgGgcatcttcactttctctgcg	4	15	8	14	2	5	0	2	0	3	0	7	0	5	0	1	1	3	3	1	1	0	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:2719000G>A	uc003zho.1	+	1	1475	c.1261G>A	c.(1261-1263)GGC>AGC	p.G421S		NM_133497	NP_598004	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	421	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(50;0.0257)		CATCGCCATGGGCATCTTCAC	0.637													11	75					0	0	0	0	A	2719000	A	A	2719000	3	1	2	1	0	0	0	0	1	0	0	0	8134	1232	43	4	1263	4	KCNV2	9	2719000	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08		2719000	138494431	95	270											
DENND4C	55667	broad.mit.edu	37	chr9	19300201	19300201	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagtggagccaactttagcAccttgctaatgaatctgggt	10	12	10	9	0	1	1	0	1	1	0	1	2	1	2	2	2	4	2	2	2	5	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:19300201A>T	uc003znq.2	+	5	508	c.475A>T	c.(475-477)ACC>TCC	p.T159S	DENND4C_uc011lnc.1_5'UTR	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	159	DENN.|Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2						CAACTTTAGCACCTTGCTAAT	0.368													13	187					0	0	0	0	T	19300201	T	T	19300201	3	4	2	1	0	0	0	0	1	0	0	0	4457	159	6	5	493	5	DENND4C	9	19300201	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	16581201	19300201	121913230	96	271											
CDKN2A	1029	broad.mit.edu	37	chr9	21971209	21971209	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctgcccatcatcatgaccTgccagagagaacagaatggt	12	7	10	12	1	2	4	2	1	0	3	2	5	2	4	3	1	3	1	3	1	2	0			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:21971209T>A	uc003zpk.2	-	2	363	c.151_splice	c.e2-1	p.V51_splice	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Splice_Site|CDKN2A_uc010miu.2_Splice_Site|CDKN2A_uc003zpl.2_Splice_Site_p.G106_splice	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1						cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(19)|p.V28_V51del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CATCATGACCTGCCAGAGAGA	0.667		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			3	4					0	0	0	0	A	21971209	A	A	21971209	5	1	2	1	0	0	0	0	0	0	1	0	3176	1594	55	5	329	5	CDKN2A	9	21971209	Splice_Site	SNP	T	TCGA-BA-4075-01A-01D-1434-08	2671008	21971209	119242222	97	272											
C9orf102	375748	broad.mit.edu	37	chr9	98718215	98718215	+	Frame_Shift_Del	DEL	T	-	-																															gagcatataggattggacaaTgtagagatgtcaaagtgctt																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:98718215delT	uc004avt.3	+	13	2288	c.1900delT	c.(1900-1902)TGTfs	p.C634fs	C9orf102_uc011lum.1_Frame_Shift_Del_p.C336fs|C9orf102_uc010mry.1_Frame_Shift_Del_p.C336fs|C9orf102_uc010mrz.2_Frame_Shift_Del_p.C445fs|C9orf102_uc004avu.2_5'UTR	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	634	Helicase C-terminal.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				GATTGGACAATGTAGAGATGT	0.358													---	---	---								-	98718215	-	-	98718215	7	5	2	1	0	1	0	1	0	0	0	0	2457	1464	51	0	1950	0	C9orf102	9	98718215	Frame_Shift_Del	DEL	T	TCGA-BA-4075-01A-01D-1434-08	76747006	98718215	42495216	98	273											
NCBP1	4686	broad.mit.edu	37	chr9	100433449	100433449	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaccctcatatcttggccGtgttccagcagttctgtgcc	6	13	9	13	1	3	1	1	0	2	1	4	1	4	1	4	1	2	3	4	1	2	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:100433449G>A	uc004axq.2	+	23	2800	c.2341G>A	c.(2341-2343)GTG>ATG	p.V781M		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	781					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				TATCTTGGCCGTGTTCCAGCA	0.423													24	120					0	0	0	0	A	100433449	A	A	100433449	3	1	2	1	0	0	0	0	1	0	0	0	10265	1145	40	1	2431	1	NCBP1	9	100433449	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	1715234	100433449	40779982	99	274											
SEC61B	10952	broad.mit.edu	37	chr9	101992659	101992659	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttatgagtcttctgttcatcGcttctgtatttatgttgcac	6	20	7	8	1	4	1	1	1	3	0	5	1	4	1	0	0	1	5	0	0	3	8			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:101992659G>C	uc004azh.2	+	4	320	c.244G>C	c.(244-246)GCT>CCT	p.A82P		NM_006808	NP_006799	P60468	SC61B_HUMAN	Sec61 beta subunit	82	Helical; (Potential).				ER-associated protein catabolic process|protein import into nucleus, translocation|retrograde protein transport, ER to cytosol|transmembrane transport	endoplasmic reticulum Sec complex|integral to membrane	epidermal growth factor binding				0		Acute lymphoblastic leukemia(62;0.0559)				TCTGTTCATCGCTTCTGTATT	0.373													8	401					0	0	0	0	C	101992659	C	C	101992659	3	2	2	1	0	0	0	0	1	0	0	0	14067	1087	38	3	258	3	SEC61B	9	101992659	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	1559210	101992659	39220772	100	275											
NR4A3	8013	broad.mit.edu	37	chr9	102606941	102606941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcattctagtactgtcccaCtgaccaggctgctgcaggca	8	10	10	13	0	1	1	0	1	1	0	2	1	2	1	2	2	4	6	2	2	2	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:102606941C>G	uc004baf.1	+	6	1994	c.1265C>G	c.(1264-1266)ACT>AGT	p.T422S	NR4A3_uc004bag.1_Missense_Mutation_p.T422S|NR4A3_uc004bai.2_Missense_Mutation_p.T433S	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	422					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				TACTGTCCCACTGACCAGGCT	0.498			T	EWSR1	extraskeletal myxoid chondrosarcoma								18	77					0	0	0	0	G	102606941	G	G	102606941	3	3	2	1	0	0	0	0	1	0	0	0	10688	565	20	4	1394	4	NR4A3	9	102606941	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	614282	102606941	38606490	101	276											
CYLC2	1539	broad.mit.edu	37	chr9	105767514	105767514	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggattcaaacaaaggcaaaGactcggcaacagaatctgaa	19	5	9	8	1	2	3	1	1	1	2	3	4	2	4	0	3	2	2	0	3	6	1	rs146533245	byFrequency	TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:105767514G>C	uc004bbs.2	+	5	671	c.601G>C	c.(601-603)GAC>CAC	p.D201H		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	201	3 X approximate tandem repeats.|31 X 3 AA repeats of K-K-X.|2.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				CAAAGGCAAAGACTCGGCAAC	0.224													5	39					0	0	0	0	C	105767514	C	C	105767514	3	2	2	1	0	0	0	0	1	0	0	0	4159	942	33	2	619	2	CYLC2	9	105767514	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	3160573	105767514	35445917	102	277											
OR13F1	138805	broad.mit.edu	37	chr9	107267227	107267227	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgccagtatcctgagaatCagctcagtggaaggtcgaag	11	8	12	10	2	2	1	2	1	0	1	5	4	3	2	2	2	1	2	2	2	4	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:107267227C>A	uc011lvm.1	+	1	684	c.684C>A	c.(682-684)ATC>ATA	p.I228I		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						TCCTGAGAATCAGCTCAGTGG	0.473													147	168					1.35182e-49	1.64392e-49	1	0	A	107267227	A	A	107267227	2	1	2	1	0	0	0	0	0	0	0	1	10995	816	29	2		2	OR13F1	9	107267227	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	1499713	107267227	33946204	103	278											
DFNB31	25861	broad.mit.edu	37	chr9	117187304	117187304	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gttgtgagatcgccaagaaaCctgtggggaaagacacacat	14	7	12	8	1	0	3	0	1	0	3	1	5	0	4	2	2	1	1	2	2	3	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:117187304C>A	uc004biz.3	-	5	1816	c.1167G>T	c.(1165-1167)GGG>GGT	p.G389G	DFNB31_uc004bix.2_Missense_Mutation_p.R38S|DFNB31_uc004biy.3_Silent_p.G6G|DFNB31_uc004bja.3_Silent_p.G389G	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	389					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CGCCAAGAAACCTGTGGGGAA	0.517													8	206					0.000157383	0.000170793	1	0	A	117187304	A	A	117187304	2	1	2	1	0	0	0	0	0	0	0	1	4477	521	18	4		4	DFNB31	9	117187304	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	9920077	117187304	24026127	104	279											
OLFML2A	169611	broad.mit.edu	37	chr9	127572376	127572376	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggcccagcccgaggtgatCgtcctgagtcgcttggaccc	6	7	14	14	3	0	2	0	2	0	0	3	5	1	3	4	3	1	1	4	3	0	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:127572376C>T	uc004bov.2	+	8	1757	c.1644C>T	c.(1642-1644)ATC>ATT	p.I548I	OLFML2A_uc004bow.2_Silent_p.I334I	NM_182487	NP_872293	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A precursor	548	Olfactomedin-like.										0						CCGAGGTGATCGTCCTGAGTC	0.662													47	46					0	0	0	0	T	127572376	T	T	127572376	2	4	2	1	0	0	0	0	0	0	0	1	10911	874	31	1		1	OLFML2A	9	127572376	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	10385072	127572376	13641055	105	280											
ADAMTS13	11093	broad.mit.edu	37	chr9	136324143	136324143	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acagcgttccatgggcagcaGgtgctctactgggagtcaga	9	8	14	10	1	2	1	1	0	1	1	3	2	3	2	1	3	4	4	1	3	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:136324143G>A	uc004cdv.3	+	29	4569	c.4125G>A	c.(4123-4125)CAG>CAA	p.Q1375Q	ADAMTS13_uc004cdp.3_Missense_Mutation_p.G485S|ADAMTS13_uc004cdt.1_Silent_p.Q1319Q|ADAMTS13_uc004cdu.1_Silent_p.Q1288Q|ADAMTS13_uc004cdw.3_Silent_p.Q1319Q|ADAMTS13_uc004cdx.3_Silent_p.Q1288Q|ADAMTS13_uc004cdz.3_Silent_p.Q1045Q|ADAMTS13_uc004ceb.3_Silent_p.Q171Q|C9orf7_uc011mdg.1_5'Flank|C9orf7_uc004cec.2_5'Flank|C9orf7_uc011mdh.1_5'Flank|C9orf7_uc011mdi.1_5'Flank|C9orf7_uc010nan.2_5'Flank	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1375	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		ATGGGCAGCAGGTGCTCTACT	0.582													4	70					0	0	0	0	A	136324143	A	A	136324143	2	1	2	1	0	0	0	0	0	0	0	1	258	991	35	4		4	ADAMTS13	9	136324143	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	8751767	136324143	4889288	106	281											
NOTCH1	4851	broad.mit.edu	37	chr9	139412299	139412299	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcgttgacgtcgatctcgCatcgggggcccgtgtagccc	5	9	13	14	6	1	1	0	1	1	0	5	2	1	1	2	2	1	3	2	2	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:139412299C>T	uc004chz.2	-	8	1346	c.1346G>A	c.(1345-1347)TGC>TAC	p.C449Y		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	449	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTCGATCTCGCATCGGGGGCC	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			80	29					0	0	0	0	T	139412299	T	T	139412299	3	4	2	1	0	0	0	0	1	0	0	0	10601	710	25	4	6429	4	NOTCH1	9	139412299	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	3088156	139412299	1801132	107	282											
EGFL7	51162	broad.mit.edu	37	chr9	139563027	139563027	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agccgtagggtgtgtgctgtCcgggctcacggggaccctgt	4	9	17	11	3	1	0	1	0	0	0	2	1	2	1	3	4	2	3	3	4	1	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr9:139563027C>T	uc004cid.2	+	4	1010	c.99C>T	c.(97-99)GTC>GTT	p.V33V	EGFL7_uc004cif.2_Silent_p.V33V|EGFL7_uc004cig.2_RNA|EGFL7_uc010nbp.2_Silent_p.V33V|EGFL7_uc004cie.2_Silent_p.V33V|EGFL7_uc004cih.2_Silent_p.V33V|MIR126_hsa-mir-126|MI0000471_5'Flank	NM_201446	NP_958854	Q9UHF1	EGFL7_HUMAN	EGF-like-domain, multiple 7	33	EMI.				angiogenesis|vasculogenesis		calcium ion binding			ovary(1)	1	all_cancers(76;0.109)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		TGTGTGCTGTCCGGGCTCACG	0.677													13	170					0	0	0	0	T	139563027	T	T	139563027	2	4	2	1	0	0	0	0	0	0	0	1	4986	842	30	2		2	EGFL7	9	139563027	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	150728	139563027	1650404	108	283											
NCOA4	8031	broad.mit.edu	37	chr10	51584772	51584772	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatggaaaaggttggagatCaagagcttcctgatcaagat	16	9	11	5	0	2	4	2	1	0	3	3	6	3	5	1	3	1	2	1	3	5	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr10:51584772C>G	uc001jis.3	+	8	1074	c.871C>G	c.(871-873)CAA>GAA	p.Q291E	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Missense_Mutation_p.Q307E|NCOA4_uc010qhd.1_Missense_Mutation_p.Q307E|NCOA4_uc010qhe.1_Missense_Mutation_p.Q191E|NCOA4_uc010qhf.1_Missense_Mutation_p.Q125E|NCOA4_uc001jit.2_Missense_Mutation_p.Q291E|NCOA4_uc009xoo.2_Missense_Mutation_p.Q291E	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	291					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						GGTTGGAGATCAAGAGCTTCC	0.438			T	RET	papillary thyroid 								4	162					0	0	0	0	G	51584772	G	G	51584772	3	3	2	1	0	0	0	0	1	0	0	0	10285	827	29	2	949	2	NCOA4	10	51584772	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08		51584772	83949975	109	284											
PCDH15	65217	broad.mit.edu	37	chr10	56138621	56138621	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaacacccagtaatccacaTtatcctttaaagaaagttct	15	12	3	11	0	2	1	1	0	1	1	4	1	4	1	3	0	1	2	3	0	6	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr10:56138621T>C	uc001jju.1	-	4	634	c.239A>G	c.(238-240)AAT>AGT	p.N80S	PCDH15_uc010qhq.1_Missense_Mutation_p.N85S|PCDH15_uc010qhr.1_Missense_Mutation_p.N80S|PCDH15_uc010qhs.1_Missense_Mutation_p.N85S|PCDH15_uc010qht.1_Missense_Mutation_p.N80S|PCDH15_uc010qhu.1_Missense_Mutation_p.N80S|PCDH15_uc001jjv.1_Missense_Mutation_p.N58S|PCDH15_uc010qhv.1_Missense_Mutation_p.N80S|PCDH15_uc010qhw.1_Missense_Mutation_p.N80S|PCDH15_uc010qhx.1_Missense_Mutation_p.N80S|PCDH15_uc010qhy.1_Missense_Mutation_p.N85S|PCDH15_uc010qhz.1_Missense_Mutation_p.N80S|PCDH15_uc010qia.1_Missense_Mutation_p.N58S|PCDH15_uc010qib.1_Missense_Mutation_p.N58S|PCDH15_uc001jjw.2_Missense_Mutation_p.N80S	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	80	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GTAATCCACATTATCCTTTAA	0.423										HNSCC(58;0.16)			37	300					0	0	0	0	C	56138621	C	C	56138621	3	2	2	1	0	0	0	0	1	0	0	0	11565	1493	52	5	7392	5	PCDH15	10	56138621	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	4553849	56138621	79396126	110	285											
ADAMTS14	140766	broad.mit.edu	37	chr10	72468481	72468481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtggacgactcggtggttCgcttccatggcaaggagcat	7	10	15	9	3	0	0	0	0	0	0	3	3	1	2	1	6	1	4	1	6	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr10:72468481C>T	uc001jrh.2	+	4	817	c.817C>T	c.(817-819)CGC>TGC	p.R273C	ADAMTS14_uc001jrg.2_Missense_Mutation_p.R273C	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	273	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						CTCGGTGGTTCGCTTCCATGG	0.617													8	125					0	0	0	0	T	72468481	T	T	72468481	3	4	2	1	0	0	0	0	1	0	0	0	259	884	31	1	831	1	ADAMTS14	10	72468481	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	16329860	72468481	63066266	111	286											
CBARA1	10367	broad.mit.edu	37	chr10	74234940	74234940	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctttcccttcagatcagctCcaaaaaagtaggttgtgagg	11	11	10	9	0	2	2	2	1	0	1	4	2	4	2	2	2	1	4	2	2	4	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr10:74234940C>T	uc001jtb.1	-	9	990	c.857G>A	c.(856-858)GGA>GAA	p.G286E	CBARA1_uc010qjw.1_Missense_Mutation_p.G86E|CBARA1_uc010qjx.1_Missense_Mutation_p.G86E|CBARA1_uc009xqo.1_RNA	NM_006077	NP_006068	Q9BPX6	MICU1_HUMAN	calcium binding atopy-related autoantigen 1	284					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			ovary(1)	1						CAGATCAGCTCCAAAAAAGTA	0.478													11	18					0	0	0	0	T	74234940	T	T	74234940	3	4	2	1	0	0	0	0	1	0	0	0	2708	855	30	2	599	2	CBARA1	10	74234940	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	1766459	74234940	61299807	112	287											
HTR7	3363	broad.mit.edu	37	chr10	92509030	92509030	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcactatgccattcagggcGatgacgctgtctggctccac	7	11	10	13	2	3	1	2	1	1	0	4	2	4	1	2	2	1	2	2	2	1	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr10:92509030G>A	uc001kha.2	-	2	1104	c.861C>T	c.(859-861)ATC>ATT	p.I287I	HTR7_uc001kgz.2_Silent_p.I287I|HTR7_uc001khb.2_Silent_p.I287I	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	287	Cytoplasmic (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	CATTCAGGGCGATGACGCTGT	0.488													5	61					0	0	0	0	A	92509030	A	A	92509030	2	1	2	1	0	0	0	0	0	0	0	1	7491	1048	37	1		1	HTR7	10	92509030	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	18274090	92509030	43025717	113	288											
PGAM1	5223	broad.mit.edu	37	chr10	99186064	99186065	+	Translation_Start_Site	INS	-	A	A																															cgcatccccagcccgccgccINSatggccgcctacaaactggt																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr10:99186064_99186065insA	uc001knh.2	+	1					uc001kng.1_5'Flank|PGAM1_uc009xvo.2_Translation_Start_Site|PGAM1_uc010qov.1_5'Flank	NM_002629	NP_002620	P18669	PGAM1_HUMAN	phosphoglycerate mutase 1						gluconeogenesis|glycolysis|regulation of glycolysis|regulation of pentose-phosphate shunt|respiratory burst	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein kinase binding				0		Colorectal(252;0.162)		Epithelial(162;8.36e-10)|all cancers(201;5.62e-08)		AGCCCGCCGCCATGGCCGCCTA	0.713													---	---	---								A	99186065	A	A	99186064	6	5	2	1	0	1	1	0	0	0	0	0	11828	609	21	0		0	PGAM1	10	99186064	Translation_Start_Site	INS	-	TCGA-BA-4075-01A-01D-1434-08	6677034	99186064	36348683	114	289											
C10orf137	26098	broad.mit.edu	37	chr10	127436201	127436201	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgggaattgtccactactTactttactatggcaactcta	11	14	6	10	0	1	0	0	0	1	0	2	1	2	1	1	2	4	1	1	2	7	7			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr10:127436201T>G	uc001liq.1	+	20	3204	c.2911T>G	c.(2911-2913)TAC>GAC	p.Y971D	C10orf137_uc001lin.2_Missense_Mutation_p.Y937D|C10orf137_uc001lio.1_Missense_Mutation_p.Y937D|C10orf137_uc001lip.1_Missense_Mutation_p.Y675D|C10orf137_uc001lis.1_Missense_Mutation_p.Y297D|C10orf137_uc001lit.1_5'Flank	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	971					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GTCCACTACTTACTTTACTAT	0.403													60	102					0	0	0	0	G	127436201	G	G	127436201	3	3	2	1	0	0	0	0	1	0	0	0	1600	1754	61	5	2883	5	C10orf137	10	127436201	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	28250137	127436201	8098546	115	290											
GPR123	84435	broad.mit.edu	37	chr10	134942077	134942077	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgcctccgtgctgcagaacGagcactcattccaggcacag	9	6	11	15	3	1	1	1	0	0	1	3	2	3	1	3	1	4	4	3	1	1	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr10:134942077G>A	uc001llx.3	+	7	1181	c.745G>A	c.(745-747)GAG>AAG	p.E249K	GPR123_uc001llw.2_Missense_Mutation_p.E968K	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	249	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GCTGCAGAACGAGCACTCATT	0.726													5	3					0	0	0	0	A	134942077	A	A	134942077	3	1	2	1	0	0	0	0	1	0	0	0	6675	1059	37	1	767	1	GPR123	10	134942077	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	7505876	134942077	592670	116	291											
ECHS1	1892	broad.mit.edu	37	chr10	135182483	135182483	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgggccttctcaccggcaTagatgatatcacacatcatg	11	10	8	12	1	3	2	3	1	1	1	4	2	3	2	2	2	0	1	2	2	2	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr10:135182483T>C	uc001lmu.2	-	4	529	c.458A>G	c.(457-459)TAT>TGT	p.Y153C		NM_004092	NP_004083	P30084	ECHM_HUMAN	mitochondrial short-chain enoyl-coenzyme A	153					fatty acid beta-oxidation	mitochondrial matrix	enoyl-CoA hydratase activity|protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;1.62e-06)|OV - Ovarian serous cystadenocarcinoma(35;5.75e-06)|Epithelial(32;7.58e-06)		CTCACCGGCATAGATGATATC	0.488													17	53					0	0	0	0	C	135182483	C	C	135182483	3	2	2	1	0	0	0	0	1	0	0	0	4918	1406	49	5	434	5	ECHS1	10	135182483	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	240406	135182483	352264	117	292											
OR5P3	120066	broad.mit.edu	37	chr11	7847182	7847182	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccatggcagccagcaggAagcactcggccgtaccaaac	12	3	12	14	2	0	0	0	0	0	0	1	1	0	1	4	4	5	4	4	4	3	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:7847182A>T	uc010rbg.1	-	1	338	c.338T>A	c.(337-339)TTC>TAC	p.F113Y		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGCCAGCAGGAAGCACTCGGC	0.552													10	184					0	0	0	0	T	7847182	T	T	7847182	3	4	2	1	0	0	0	0	1	0	0	0	11233	246	9	5	600	5	OR5P3	11	7847182	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08		7847182	127159334	118	293											
PRMT3	10196	broad.mit.edu	37	chr11	20419170	20419170	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacagatgtcagaacctgctCgtcatctactagtgtcattg	10	12	8	11	1	4	2	3	0	1	2	5	2	4	2	1	0	3	1	1	0	3	3	rs142076035		TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:20419170C>T	uc001mqb.2	+	7	825	c.608C>T	c.(607-609)TCG>TTG	p.S203L	PRMT3_uc001mqc.2_Missense_Mutation_p.S126L|PRMT3_uc010rdn.1_Missense_Mutation_p.S141L	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1	203							zinc ion binding				0						AGAACCTGCTCGTCATCTACT	0.413													87	114					0	0	0	0	T	20419170	T	T	20419170	3	4	2	1	0	0	0	0	1	0	0	0	12600	893	31	1	634	1	PRMT3	11	20419170	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	12571988	20419170	114587346	119	294											
KBTBD4	55709	broad.mit.edu	37	chr11	47594940	47594940	+	Frame_Shift_Del	DEL	C	-	-																															accagcagcccctgacacagCcacctctagctgagttgtct																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:47594940delC	uc001nfx.2	-	4	1270	c.1099delG	c.(1099-1101)GCTfs	p.A367fs	PTPMT1_uc001nfs.3_3'UTR|PTPMT1_uc001nfv.3_3'UTR|PTPMT1_uc009ylt.2_3'UTR|PTPMT1_uc001nfu.3_3'UTR|NDUFS3_uc001nft.3_Intron|KBTBD4_uc001nfw.1_Frame_Shift_Del_p.A392fs|KBTBD4_uc001nfz.2_Frame_Shift_Del_p.A383fs|KBTBD4_uc001nfy.2_Frame_Shift_Del_p.A367fs	NM_016506	NP_057590	Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	367	Kelch 3.									ovary(1)|central_nervous_system(1)	2						CCTGACACAGCCACCTCTAGC	0.507													---	---	---								-	47594940	-	-	47594940	7	5	2	1	0	1	0	1	0	0	0	0	8034	739	26	0	461	0	KBTBD4	11	47594940	Frame_Shift_Del	DEL	C	TCGA-BA-4075-01A-01D-1434-08	27175770	47594940	87411576	120	295											
NUP160	23279	broad.mit.edu	37	chr11	47857319	47857319	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccgaaggtctttcttcacagGgacatactccagcatgtcag	10	10	9	12	1	4	0	2	0	2	0	5	2	5	1	2	2	2	1	2	2	2	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:47857319G>A	uc001ngm.2	-	7	1070	c.985C>T	c.(985-987)CCT>TCT	p.P329S	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	329					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						TTCTTCACAGGGACATACTCC	0.453													18	178					0	0	0	0	A	47857319	A	A	47857319	3	1	2	1	0	0	0	0	1	0	0	0	10811	1232	43	4	3445	4	NUP160	11	47857319	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	262379	47857319	87149197	121	296											
OR5L2	26338	broad.mit.edu	37	chr11	55595192	55595192	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcgtccttagctcttaggatCctcttctatagatctaatgt	8	17	6	10	1	4	1	0	0	4	1	7	2	6	2	2	1	1	1	2	1	5	6			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:55595192C>A	uc001nhy.1	+	1	498	c.498C>A	c.(496-498)ATC>ATA	p.I166I		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CTCTTAGGATCCTCTTCTATA	0.478										HNSCC(27;0.073)			13	431					0.00185496	0.00196026	1	0	A	55595192	A	A	55595192	2	1	2	1	0	0	0	0	0	0	0	1	11225	845	30	2		2	OR5L2	11	55595192	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	7737873	55595192	79411324	122	297											
FAM111B	374393	broad.mit.edu	37	chr11	58892538	58892542	+	Frame_Shift_Del	DEL	AAATT	-	-																															tgtagaacacagcagagagcAaattctcccacctcaggatc																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:58892538_58892542delAAATT	uc001nnl.2	+	4	1211_1215	c.968_972delAAATT	c.(967-972)CAAATTfs	p.Q323fs	FAM111B_uc001nnm.2_Frame_Shift_Del_p.Q293fs|FAM111B_uc010rko.1_Frame_Shift_Del_p.Q293fs	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	323_324							catalytic activity			ovary(2)	2						AGCAGAGAGCAAATTCTCCCACCTC	0.366													---	---	---								-	58892542	-	-	58892538	7	5	2	1	0	1	0	1	0	0	0	0	5428	130	5	0	974	0	FAM111B	11	58892538	Frame_Shift_Del	DEL	AAATT	TCGA-BA-4075-01A-01D-1434-08	3297346	58892538	76113978	123	298											
CYBASC3	220002	broad.mit.edu	37	chr11	61120500	61120500	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatgcccgaaatgacggatgCgatggacagagagaggatgg	14	5	16	6	3	0	3	0	1	0	2	0	9	0	6	1	4	2	0	1	4	2	0			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:61120500C>T	uc001nrf.3	-	3	681	c.505G>A	c.(505-507)GCA>ACA	p.A169T	CYBASC3_uc010rlh.1_Missense_Mutation_p.A186T|CYBASC3_uc001nrg.2_Missense_Mutation_p.A169T|CYBASC3_uc009ynn.2_RNA|CYBASC3_uc001nrh.2_Missense_Mutation_p.A169T|CYBASC3_uc001nri.2_RNA	NM_001161452	NP_001154924	Q8NBI2	CYAC3_HUMAN	cytochrome b, ascorbate dependent 3 isoform 2	169	Helical; Name=5; (Potential).|Cytochrome b561.				electron transport chain|transport	integral to membrane|late endosome membrane|lysosomal membrane	metal ion binding|oxidoreductase activity				0						ATGACGGATGCGATGGACAGA	0.522													16	50					0	0	0	0	T	61120500	T	T	61120500	3	4	2	1	0	0	0	0	1	0	0	0	4149	768	27	1	235	1	CYBASC3	11	61120500	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	2227962	61120500	73886016	124	299											
UBXN1	51035	broad.mit.edu	37	chr11	62445536	62445536	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgttcccgttccaatgcctcCcgttcctctctttcttcacg	3	15	5	18	4	3	0	1	0	2	0	8	0	7	0	5	0	1	3	5	0	1	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:62445536C>T	uc001nul.1	-	5	477	c.345G>A	c.(343-345)CGG>CGA	p.R115R	UBXN1_uc001nuj.2_Silent_p.R115R|UBXN1_uc001num.1_Silent_p.R115R|UBXN1_uc001nuk.2_Silent_p.R80R|UBXN1_uc010rme.1_Silent_p.R115R|UBXN1_uc010rmf.1_3'UTR	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	115	Potential.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						CCAATGCCTCCCGTTCCTCTC	0.587													5	124					0	0	0	0	T	62445536	T	T	62445536	2	4	2	1	0	0	0	0	0	0	0	1	16979	610	22	4		4	UBXN1	11	62445536	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	1325036	62445536	72560980	125	300											
ZBTB3	79842	broad.mit.edu	37	chr11	62520234	62520234	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcaactttcacctggacCagctcagcttcagctggggc	7	10	10	14	0	4	0	4	0	0	0	4	1	4	1	2	3	4	4	2	3	1	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:62520234C>G	uc001nuz.2	-	2	1175	c.1053G>C	c.(1051-1053)CTG>CTC	p.L351L		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						TCACCTGGACCAGCTCAGCTT	0.313													5	138					0	0	0	0	G	62520234	G	G	62520234	2	3	2	1	0	0	0	0	0	0	0	1	17601	581	21	4		4	ZBTB3	11	62520234	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	74698	62520234	72486282	126	301											
CCND1	595	broad.mit.edu	37	chr11	69462871	69462871	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aacttcctgtcctactaccgCctcacacgcttcctctccag	7	11	4	19	2	2	0	1	0	1	0	6	0	5	0	6	0	3	1	6	0	3	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:69462871C>T	uc001opa.2	+	4	893	c.684C>T	c.(682-684)CGC>CGT	p.R228R		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	228					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	CCTACTACCGCCTCACACGCT	0.612			T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			13	516					0	0	0	0	T	69462871	T	T	69462871	2	4	2	1	0	0	0	0	0	0	0	1	2931	726	26	4		4	CCND1	11	69462871	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	6942637	69462871	65543645	127	302											
FAT3	120114	broad.mit.edu	37	chr11	92088408	92088408	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acctccacactccctatttcCcagactttgctgttgttgga	7	14	6	14	0	0	1	0	0	0	1	3	2	3	2	4	1	1	3	4	1	1	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:92088408C>A	uc001pdj.3	+	1	3147	c.3130C>A	c.(3130-3132)CCA>ACA	p.P1044T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1044	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCCCTATTTCCCAGACTTTGC	0.507										TCGA Ovarian(4;0.039)			4	59					0.00909568	0.00932693	1	0	A	92088408	A	A	92088408	3	1	2	1	0	0	0	0	1	0	0	0	5723	623	22	4	3132	4	FAT3	11	92088408	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	22625537	92088408	42918108	128	303											
ZNF259	8882	broad.mit.edu	37	chr11	116653688	116653688	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtgaacttgcccccgaGgactgccattcccagttcaa	8	10	10	13	1	1	1	1	1	0	0	2	3	2	2	4	2	3	1	4	2	2	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr11:116653688G>A	uc001ppp.2	-	11	1072	c.1039C>T	c.(1039-1041)CTC>TTC	p.L347F	ZNF259_uc009yzd.2_Missense_Mutation_p.L347F|ZNF259_uc001ppq.2_Missense_Mutation_p.L277F	NM_003904	NP_003895	O75312	ZPR1_HUMAN	zinc finger protein 259	347					cell proliferation|signal transduction	cytoplasm|nucleolus					0	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		TTGCCCCCGAGGACTGCCATT	0.478													118	43					0	0	0	0	A	116653688	A	A	116653688	3	1	2	1	0	0	0	0	1	0	0	0	17868	1000	35	4	356	4	ZNF259	11	116653688	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	24565280	116653688	18352828	129	304											
ABCC9	10060	broad.mit.edu	37	chr12	22063175	22063175	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggcgactaagttgttgatCtgccccagagtcatctcccc	8	11	9	13	1	3	2	1	1	2	1	4	3	3	2	4	1	1	2	4	1	1	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:22063175C>G	uc001rfi.1	-	8	1256	c.1236G>C	c.(1234-1236)CAG>CAC	p.Q412H	ABCC9_uc001rfh.2_Missense_Mutation_p.Q412H|ABCC9_uc001rfj.1_Missense_Mutation_p.Q412H	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	412	Cytoplasmic (Potential).|ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGTTGTTGATCTGCCCCAGAG	0.378													7	176					0	0	0	0	G	22063175	G	G	22063175	3	3	2	1	0	0	0	0	1	0	0	0	59	912	32	2	3679	2	ABCC9	12	22063175	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08		22063175	111788720	130	305											
FGD4	121512	broad.mit.edu	37	chr12	32777925	32777925	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaggcccttcaagaaaccAtcgatgcttttcatcaaagg	12	12	7	10	1	3	1	3	0	0	1	4	2	3	1	2	2	2	1	2	2	4	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:32777925A>G	uc001rkz.2	+	13	2035	c.1558A>G	c.(1558-1560)ATC>GTC	p.I520V	FGD4_uc001rlc.2_Missense_Mutation_p.I605V|FGD4_uc001rky.2_Missense_Mutation_p.I272V|FGD4_uc001rla.2_Missense_Mutation_p.I176V|FGD4_uc010ske.1_Missense_Mutation_p.I632V|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	520	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					TCAAGAAACCATCGATGCTTT	0.308													117	121					0	0	0	0	G	32777925	G	G	32777925	3	3	2	1	0	0	0	0	1	0	0	0	5867	217	8	5	1600	5	FGD4	12	32777925	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	10714750	32777925	101073970	131	306											
ABCD2	225	broad.mit.edu	37	chr12	39947881	39947881	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatagcagtatccaattgttCaaagcgccaacctccttcac	12	10	6	13	1	2	0	2	0	0	0	4	1	4	0	4	0	3	3	4	0	5	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:39947881C>A	uc001rmb.2	-	10	2482	c.2056G>T	c.(2056-2058)GAA>TAA	p.E686*		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	686	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						TCCAATTGTTCAAAGCGCCAA	0.348													7	119					1.26484e-09	1.45758e-09	1	0	A	39947881	A	A	39947881	4	1	2	1	0	0	0	0	0	1	0	0	61	835	29	2	170	2	ABCD2	12	39947881	Nonsense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	7169956	39947881	93904014	132	307											
ADAMTS20	80070	broad.mit.edu	37	chr12	43824171	43824171	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacctgtctgtcactggggCgactagcttcatggcattct	6	14	10	11	1	4	0	2	0	2	0	4	1	4	0	1	3	2	2	1	3	2	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:43824171C>T	uc010skx.1	-	23	3365	c.3365G>A	c.(3364-3366)CGC>CAC	p.R1122H	ADAMTS20_uc001rno.1_Missense_Mutation_p.R276H|ADAMTS20_uc001rnp.1_Missense_Mutation_p.R276H	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1122	TSP type-1 6.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GTCACTGGGGCGACTAGCTTC	0.368													5	37					0	0	0	0	T	43824171	T	T	43824171	3	4	2	1	0	0	0	0	1	0	0	0	266	768	27	1	2434	1	ADAMTS20	12	43824171	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	3876290	43824171	90027724	133	308											
MLL2	8085	broad.mit.edu	37	chr12	49425941	49425942	+	Nonsense_Mutation	DNP	GC	AA	AA																															tccaaccccaggcagaccctGcccagactggaggacaggtc																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:49425941_49425942GC>AA	uc001rta.3	-	39	12546_12547	c.12546_12547GC>TT	c.(12544-12549)GGGCAG>GGTTAG	p.Q4183*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4183	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCAGACCCTGCCCAGACTGGA	0.594			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			6	127					0	0	0	0	AA	49425942	AA	AA	49425941	4	1	2	1	0	0	0	0	0	1	0	0	9674	1328	46	4	4130	4	MLL2	12	49425941	Nonsense_Mutation	DNP	GC	TCGA-BA-4075-01A-01D-1434-08	5601770	49425941	84425954	134	309											
SLC11A2	4891	broad.mit.edu	37	chr12	51404506	51404506	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcttctgttcaggacccagCaccatggtggatacctgagt	9	11	10	11	0	3	1	1	1	2	0	3	3	3	3	3	3	2	2	3	3	1	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:51404506C>T	uc001rxe.3	-	2	103	c.6G>A	c.(4-6)GTG>GTA	p.V2V	SLC11A2_uc001rxd.3_5'UTR|SLC11A2_uc001rxc.3_Silent_p.V2V|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc010smx.1_5'Flank|SLC11A2_uc001rxh.1_Silent_p.V2V|SLC11A2_uc001rxj.1_Silent_p.V2V|SLC11A2_uc001rxi.2_Silent_p.V2V|SLC11A2_uc001rxk.1_Silent_p.V31V|SLC11A2_uc010smy.1_5'UTR	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	2	Cytoplasmic (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						CAGGACCCAGCACCATGGTGG	0.363													10	53					0	0	0	0	T	51404506	T	T	51404506	2	4	2	1	0	0	0	0	0	0	0	1	14446	697	25	4		4	SLC11A2	12	51404506	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	1978565	51404506	82447389	135	310											
NCKAP1L	3071	broad.mit.edu	37	chr12	54932700	54932700	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcctcttgcagctgggccaGgagactgacaagcttaaaac	12	7	11	11	0	1	2	0	1	1	1	1	3	1	2	2	2	5	3	2	2	3	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:54932700G>A	uc001sgc.3	+	30	3295	c.3216G>A	c.(3214-3216)CAG>CAA	p.Q1072Q	NCKAP1L_uc010sox.1_Silent_p.Q614Q|NCKAP1L_uc010soy.1_Silent_p.Q1022Q	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	1072					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						AGCTGGGCCAGGAGACTGACA	0.448													3	87					0	0	0	0	A	54932700	A	A	54932700	2	1	2	1	0	0	0	0	0	0	0	1	10276	991	35	4		4	NCKAP1L	12	54932700	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	3528194	54932700	78919195	136	311											
SMARCC2	6601	broad.mit.edu	37	chr12	56566447	56566447	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgttggtttctctttgccTttgtcaggaaagttgagcat	6	18	10	7	0	3	1	1	1	2	0	4	2	3	2	1	2	2	4	1	2	1	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:56566447T>C	uc001skb.2	-	18	1798	c.1692A>G	c.(1690-1692)AAA>AAG	p.K564K	SMARCC2_uc001skd.2_Silent_p.K595K|SMARCC2_uc001ska.2_Silent_p.K595K|SMARCC2_uc001skc.2_Silent_p.K594K|SMARCC2_uc010sqf.1_Silent_p.K484K	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	564					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TCTCTTTGCCTTTGTCAGGAA	0.502													61	148					0	0	0	0	C	56566447	C	C	56566447	2	2	2	1	0	0	0	0	0	0	0	1	14840	1606	56	5		5	SMARCC2	12	56566447	Silent	SNP	T	TCGA-BA-4075-01A-01D-1434-08	1633747	56566447	77285448	137	312											
MDM2	4193	broad.mit.edu	37	chr12	69233471	69233471	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgccattgaaccttgtgtgAtttgtcaaggtcgacctaaa	11	13	9	8	1	1	2	1	2	0	0	2	3	1	2	3	1	2	0	3	1	4	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:69233471A>G	uc001sui.2	+	11	1623	c.1336A>G	c.(1336-1338)ATT>GTT	p.I446V	MDM2_uc009zri.2_Missense_Mutation_p.I401V|MDM2_uc009zqx.2_Missense_Mutation_p.I391V|MDM2_uc009zqw.2_Nonstop_Mutation_p.*173W|MDM2_uc001suk.2_Intron|MDM2_uc001sun.3_Missense_Mutation_p.I265V|MDM2_uc009zqz.2_Missense_Mutation_p.I393V|MDM2_uc009zra.2_Missense_Mutation_p.I244V|MDM2_uc001sum.1_Missense_Mutation_p.I74V|MDM2_uc009zrd.2_Missense_Mutation_p.I130V|MDM2_uc009zrc.2_Missense_Mutation_p.I130V|MDM2_uc009zre.2_Missense_Mutation_p.I187V|MDM2_uc009zrf.2_Missense_Mutation_p.I130V|MDM2_uc001suo.2_Missense_Mutation_p.I240V|MDM2_uc009zrg.2_Missense_Mutation_p.I162V|MDM2_uc009zrh.2_Missense_Mutation_p.I214V	NM_002392	NP_002383	Q00987	MDM2_HUMAN	mouse double minute 2 homolog isoform MDM2	440	Necessary for interaction with USP2.|RING-type.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			ACCTTGTGTGATTTGTCAAGG	0.408			A		sarcoma|glioma|colorectal|other								9	114					0	0	0	0	G	69233471	G	G	69233471	3	3	2	1	0	0	0	0	1	0	0	0	9466	333	12	5	1378	5	MDM2	12	69233471	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	12667024	69233471	64618424	138	313											
NDUFA12	55967	broad.mit.edu	37	chr12	95365236	95365236	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttacttgtaaggtgttgaagGtgggatccactcctgaatct	9	14	11	7	0	1	2	0	2	1	0	3	3	3	3	2	3	1	2	2	3	4	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:95365236G>A	uc001tdl.2	-	4	473	c.418C>T	c.(418-420)CCT>TCT	p.P140S		NM_018838	NP_061326	Q9UI09	NDUAC_HUMAN	13kDa differentiation-associated protein	140					respiratory electron transport chain|respiratory gaseous exchange|response to oxidative stress|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	GGTGTTGAAGGTGGGATCCAC	0.358													15	148					0	0	0	0	A	95365236	A	A	95365236	3	1	2	1	0	0	0	0	1	0	0	0	10316	1261	44	4	23	4	NDUFA12	12	95365236	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	26131765	95365236	38486659	139	314											
VEZT	55591	broad.mit.edu	37	chr12	95645720	95645720	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgtgtctttttcagaattCtccactttaccaatacttac	9	19	3	10	0	3	1	1	0	2	1	4	1	3	1	2	0	3	0	2	0	5	8			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:95645720C>T	uc001tdz.2	+	2	146	c.41C>T	c.(40-42)TCT>TTT	p.S14F	VEZT_uc009zsy.1_5'UTR|VEZT_uc001tdr.2_5'UTR|VEZT_uc001tds.2_5'UTR|VEZT_uc001tdt.2_5'UTR|VEZT_uc009zsz.1_Missense_Mutation_p.S14F|VEZT_uc001tdv.2_5'UTR|VEZT_uc001tdw.1_5'UTR|VEZT_uc009zta.1_5'UTR	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	14						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						TTTCAGAATTCTCCACTTTAC	0.363													9	97					0	0	0	0	T	95645720	T	T	95645720	3	4	2	1	0	0	0	0	1	0	0	0	17224	913	32	2	47	2	VEZT	12	95645720	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	280484	95645720	38206175	140	315											
RBM19	9904	broad.mit.edu	37	chr12	114358415	114358415	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agctgagaatcttcactttaCctggagctgcttgagagctt	9	13	10	9	0	2	2	1	2	1	2	2	5	2	3	1	1	5	4	1	1	2	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:114358415C>A	uc009zwi.2	-	19	2529	c.2385_splice	c.e19+1	p.Q795_splice	RBM19_uc001tvn.3_Splice_Site_p.Q795_splice|RBM19_uc001tvm.2_Splice_Site_p.Q795_splice	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19						multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					cTTCACTTTACCTGGAGCTGC	0.279													23	422					0.00047179	0.000509701	1	0	A	114358415	A	A	114358415	5	1	2	1	0	0	0	0	0	0	1	0	13186	521	18	4	520	4	RBM19	12	114358415	Splice_Site	SNP	C	TCGA-BA-4075-01A-01D-1434-08	18712695	114358415	19493480	141	316											
RBM19	9904	broad.mit.edu	37	chr12	114404022	114404022	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgggagattcttcacgatcAgtcgcgacatggcgcagggt	8	9	14	10	5	3	1	2	0	1	1	5	4	3	1	0	3	0	1	0	3	0	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:114404022A>C	uc009zwi.2	-	1	155	c.11T>G	c.(10-12)CTG>CGG	p.L4R	RBM19_uc001tvn.3_Missense_Mutation_p.L4R|RBM19_uc001tvm.2_Missense_Mutation_p.L4R	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	4	RRM 1.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					CTTCACGATCAGTCGCGACAT	0.582											OREG0022146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	93					0	0	0	0	C	114404022	C	C	114404022	3	2	2	1	0	0	0	0	1	0	0	0	13186	188	7	5	2967	5	RBM19	12	114404022	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	45607	114404022	19447873	142	317											
DNAH10	196385	broad.mit.edu	37	chr12	124297944	124297944	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggacaaagctattgtgatGgagaaatttgctgccaagaa	14	11	11	5	0	0	3	0	1	0	2	0	5	0	4	1	2	3	2	1	2	5	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr12:124297944G>A	uc001uft.3	+	19	3049	c.3024G>A	c.(3022-3024)ATG>ATA	p.M1008I	DNAH10_uc010tav.1_Missense_Mutation_p.M550I|DNAH10_uc010taw.1_Missense_Mutation_p.M493I	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1008	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTATTGTGATGGAGAAATTTG	0.403													10	197					0	0	0	0	A	124297944	A	A	124297944	3	1	2	1	0	0	0	0	1	0	0	0	4620	1348	47	4	3098	4	DNAH10	12	124297944	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	9893922	124297944	9553951	143	318											
C1QTNF9B	387911	broad.mit.edu	37	chr13	24470966	24470966	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtcaggtgagtacctgcatCgcctttgtcacccttcgctc	5	12	9	15	3	2	1	2	1	0	0	5	1	2	1	3	1	2	3	3	1	1	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:24470966C>T	uc010tcw.1	-	1	160	c.160G>A	c.(160-162)GAT>AAT	p.D54N	C1QTNF9B_uc010tcv.1_Silent_p.A17A|C1QTNF9B_uc001uoz.1_Missense_Mutation_p.D54N|C1QTNF9B_uc010tcx.1_Missense_Mutation_p.D54N	NM_001007537	NP_001007538	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	54	Collagen-like 1.					collagen					0						GTACCTGCATCGCCTTTGTCA	0.512													6	132					0	0	0	0	T	24470966	T	T	24470966	3	4	2	1	0	0	0	0	1	0	0	0	1980	884	31	1	852	1	C1QTNF9B	13	24470966	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08		24470966	90698912	144	319											
FLT3	2322	broad.mit.edu	37	chr13	28599056	28599056	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatccgagtccgggtgtatCtgaacttctcttgaaccagg	8	12	11	10	2	2	3	0	3	2	0	5	4	4	3	3	2	2	1	3	2	3	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:28599056C>T	uc001urw.2	-	18	2314	c.2232G>A	c.(2230-2232)CAG>CAA	p.Q744Q	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Silent_p.Q744Q	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	744	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CCGGGTGTATCTGAACTTCTC	0.308			Mis|O		AML|ALL								143	112					0	0	0	0	T	28599056	T	T	28599056	2	4	2	1	0	0	0	0	0	0	0	1	5974	912	32	2		2	FLT3	13	28599056	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	4128090	28599056	86570822	145	320											
PAN3	255967	broad.mit.edu	37	chr13	28854571	28854571	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgttgactgaccaaaacAggatgcgaagtgtaaatgac	15	10	10	6	1	0	3	0	3	0	0	0	5	0	4	1	1	2	2	1	1	5	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:28854571A>C	uc001urz.2	+	15	1782	c.1774A>C	c.(1774-1776)AGG>CGG	p.R592R	PAN3_uc001ury.2_Silent_p.R426R|PAN3_uc001urx.2_Silent_p.R538R	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	738	Protein kinase.|Interaction with PAN2.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TGACCAAAACAGGATGCGAAG	0.373													94	85					0	0	0	0	C	28854571	C	C	28854571	2	2	2	1	0	0	0	0	0	0	0	1	11469	179	7	5		5	PAN3	13	28854571	Silent	SNP	A	TCGA-BA-4075-01A-01D-1434-08	255515	28854571	86315307	146	321											
RCBTB2	1102	broad.mit.edu	37	chr13	49086282	49086282	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgatccagatcctacctgcCcagagttattataaccccag	11	11	6	13	0	0	3	0	1	0	2	2	3	2	3	6	0	3	1	6	0	4	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:49086282C>A	uc001vch.2	-	8	916	c.545G>T	c.(544-546)GGG>GTG	p.G182V	RCBTB2_uc010tgg.1_Missense_Mutation_p.G187V|RCBTB2_uc001vci.2_Missense_Mutation_p.G158V|RCBTB2_uc010tgh.1_Intron|RCBTB2_uc001vcj.2_Missense_Mutation_p.G186V|RCBTB2_uc010acv.1_RNA|RCBTB2_uc010tgi.1_Missense_Mutation_p.G158V	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	182	RCC1 3.						Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		TCCTACCTGCCCAGAGTTATT	0.408													11	232					1.58986e-06	1.78952e-06	1	0	A	49086282	A	A	49086282	3	1	2	1	0	0	0	0	1	0	0	0	13237	623	22	4	1142	4	RCBTB2	13	49086282	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	20231711	49086282	66083596	147	322											
PIBF1	10464	broad.mit.edu	37	chr13	73467981	73467981	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaatttctccatcaaagtaAattaaaatcttttgaaagtg	17	14	5	5	0	3	2	1	1	2	1	4	2	3	2	1	0	0	1	1	0	7	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:73467981A>T	uc001vjc.2	+	11	1687	c.1382A>T	c.(1381-1383)AAA>ATA	p.K461I	PIBF1_uc010aeo.1_RNA|PIBF1_uc001vjb.2_Missense_Mutation_p.K461I|PIBF1_uc010aep.2_Intron	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	461						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		CATCAAAGTAAATTAAAATCT	0.343													32	81					0	0	0	0	T	73467981	T	T	73467981	3	4	2	1	0	0	0	0	1	0	0	0	11934	14	1	5	1420	5	PIBF1	13	73467981	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	24381699	73467981	41701897	148	323											
RBM26	64062	broad.mit.edu	37	chr13	79911341	79911341	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaccaggcacacctcgccCtcgccctcgccccctgcctc	5	6	7	23	3	0	1	0	1	0	0	4	1	0	1	7	1	1	1	7	1	0	0			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:79911341C>A	uc001vkz.2	-	19	2649	c.2635G>T	c.(2635-2637)GGG>TGG	p.G879W	RBM26_uc001vky.2_Missense_Mutation_p.G850W|RBM26_uc001vla.2_Missense_Mutation_p.G853W|RBM26_uc010tia.1_Missense_Mutation_p.G234W|RBM26_uc001vkx.2_Missense_Mutation_p.G589W	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	877					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		ACACCTCGCCCTCGCCCTCGC	0.557													7	107					8.12818e-05	8.90055e-05	1	0	A	79911341	A	A	79911341	3	1	2	1	0	0	0	0	1	0	0	0	13191	681	24	4	410	4	RBM26	13	79911341	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	6443360	79911341	35258537	149	324											
SLITRK5	26050	broad.mit.edu	37	chr13	88327784	88327784	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgattattatggggaaatCtgtgacaatgcatgtccttg	11	14	10	6	1	1	1	0	1	1	0	3	3	2	2	1	2	1	1	1	2	4	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:88327784C>A	uc001vln.2	+	2	360	c.141C>A	c.(139-141)ATC>ATA	p.I47I	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	47	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ATGGGGAAATCTGTGACAATG	0.458													98	124					2.5264e-35	3.04174e-35	1	0	A	88327784	A	A	88327784	2	1	2	1	0	0	0	0	0	0	0	1	14810	903	32	2		2	SLITRK5	13	88327784	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	8416443	88327784	26842094	150	325											
FARP1	10160	broad.mit.edu	37	chr13	99042216	99042216	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attttccctttttagagtgcGtaccaggataccttggaatt	9	16	8	8	1	0	1	0	0	0	1	1	3	1	3	3	2	3	1	3	2	4	9			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:99042216G>A	uc001vnj.2	+	10	1197	c.861G>A	c.(859-861)GCG>GCA	p.A287A	FARP1_uc001vnh.2_Silent_p.A287A	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	287	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TTTAGAGTGCGTACCAGGATA	0.418													29	272					0	0	0	0	A	99042216	A	A	99042216	2	1	2	1	0	0	0	0	0	0	0	1	5708	1132	40	1		1	FARP1	13	99042216	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	10714432	99042216	16127662	151	326											
MYO16	23026	broad.mit.edu	37	chr13	109817248	109817248	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttttctaaaatttattttaGgttttgaaactaacatgaac	14	18	5	4	0	1	2	0	2	1	0	1	2	1	2	0	1	3	2	0	1	7	10			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:109817248G>C	uc001vqt.1	+	33	5225	c.5099_splice	c.e33-1	p.G1700_splice	MYO16_uc010agk.1_Splice_Site_p.G1722_splice	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8						cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ATTTATTTTAGGTTTTGAAAC	0.284													25	55					0	0	0	0	C	109817248	C	C	109817248	5	2	2	1	0	0	0	0	0	0	1	0	10117	1014	35	4	5224	4	MYO16	13	109817248	Splice_Site	SNP	G	TCGA-BA-4075-01A-01D-1434-08	10775032	109817248	5352630	152	327											
CUL4A	8451	broad.mit.edu	37	chr13	113914958	113914958	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccactgagagagtgtttcAggatagacaatatcagattg	14	10	10	7	0	2	4	2	1	0	3	2	6	2	5	1	1	0	1	1	1	3	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:113914958A>C	uc010tjy.1	+	20	2080	c.2069A>C	c.(2068-2070)CAG>CCG	p.Q690P	CUL4A_uc010tjx.1_Missense_Mutation_p.Q590P|CUL4A_uc010agu.2_Missense_Mutation_p.Q551P|CUL4A_uc010tjz.1_Missense_Mutation_p.Q369P	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	690					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			AGAGTGTTTCAGGATAGACAA	0.299													3	70					0	0	0	0	C	113914958	C	C	113914958	3	2	2	1	0	0	0	0	1	0	0	0	4074	188	7	5	2143	5	CUL4A	13	113914958	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	4097710	113914958	1254920	153	328											
GAS6	2621	broad.mit.edu	37	chr13	114535695	114535695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caaggacttcacactcttggCcacgctgaagggcacgcacg	10	6	11	14	3	2	1	1	1	1	0	2	2	2	2	1	3	0	3	1	3	2	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr13:114535695C>T	uc001vud.2	-	9	1018	c.865G>A	c.(865-867)GCC>ACC	p.A289T	GAS6_uc001vug.2_5'UTR|GAS6_uc001vuf.2_Missense_Mutation_p.A16T	NM_000820	NP_000811	Q14393	GAS6_HUMAN	growth arrest-specific 6 isoform 1 precursor	332					cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)	4	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				ACACTCTTGGCCACGCTGAAG	0.667													8	160					0	0	0	0	T	114535695	T	T	114535695	3	4	2	1	0	0	0	0	1	0	0	0	6284	739	26	4	1199	4	GAS6	13	114535695	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	620737	114535695	634183	154	329											
KHNYN	23351	broad.mit.edu	37	chr14	24900024	24900024	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggttcgggaacagcagcccCatgtggagcgcatcttcagc	9	7	13	12	2	2	0	1	0	1	0	3	2	2	2	2	3	5	3	2	3	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr14:24900024C>T	uc001wph.3	+	2	290	c.88C>T	c.(88-90)CAT>TAT	p.H30Y	KHNYN_uc010tpc.1_Missense_Mutation_p.H71Y|KHNYN_uc010alw.2_Missense_Mutation_p.H30Y|CBLN3_uc001wpg.3_5'Flank	NM_015299	NP_056114	O15037	KHNYN_HUMAN	hypothetical protein LOC23351	30										ovary(2)|liver(1)	3						ACAGCAGCCCCATGTGGAGCG	0.667													9	15					0	0	0	0	T	24900024	T	T	24900024	3	4	2	1	0	0	0	0	1	0	0	0	8189	594	21	4	90	4	KHNYN	14	24900024	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08		24900024	82449516	155	330											
WDR89	112840	broad.mit.edu	37	chr14	64066011	64066011	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccaatacagcttactgatGaaattgagttacaggttgta	15	12	8	6	0	0	3	0	3	0	0	0	3	0	3	1	1	5	4	1	1	7	6			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr14:64066011G>A	uc001xgh.2	-	3	896	c.650C>T	c.(649-651)TCA>TTA	p.S217L	WDR89_uc001xgi.2_Missense_Mutation_p.S217L	NM_001008726	NP_001008726	Q96FK6	WDR89_HUMAN	WD repeat domain 89	217	WD 5.										0				OV - Ovarian serous cystadenocarcinoma(108;0.00543)|all cancers(60;0.0181)|BRCA - Breast invasive adenocarcinoma(234;0.101)		GCTTACTGATGAAATTGAGTT	0.373													53	274					0	0	0	0	A	64066011	A	A	64066011	3	1	2	1	0	0	0	0	1	0	0	0	17404	1294	45	2	517	2	WDR89	14	64066011	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	39165987	64066011	43283529	156	331											
TMEM63C	57156	broad.mit.edu	37	chr14	77703058	77703058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atcactgcctggggtttgcaCccaggaatagccaaaaggta	12	8	11	10	0	1	0	1	0	0	0	1	1	1	1	3	4	3	3	3	4	5	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr14:77703058C>T	uc001xtf.2	+	9	846	c.634C>T	c.(634-636)CCC>TCC	p.P212S	TMEM63C_uc010asq.1_Missense_Mutation_p.P212S	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	212						integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		GGGGTTTGCACCCAGGAATAG	0.547													6	145					0	0	0	0	T	77703058	T	T	77703058	3	4	2	1	0	0	0	0	1	0	0	0	16258	507	18	4	660	4	TMEM63C	14	77703058	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	13637047	77703058	29646482	157	332											
SNW1	22938	broad.mit.edu	37	chr14	78189539	78189539	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctacctcttatcaggagctGccctggaaagattccggtca	9	10	9	13	1	3	1	2	0	1	1	4	3	4	3	4	3	3	1	4	3	3	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr14:78189539G>T	uc001xuf.2	-	11	1142	c.1115C>A	c.(1114-1116)GCA>GAA	p.A372E	SNW1_uc010tvm.1_Missense_Mutation_p.A297E|SNW1_uc010asu.2_Missense_Mutation_p.A210E|SNW1_uc010tvn.1_Missense_Mutation_p.A372E	NM_012245	NP_036377	Q13573	SNW1_HUMAN	SKI-interacting protein	372					negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		ATCAGGAGCTGCCCTGGAAAG	0.358													35	182					7.63505e-26	9.14694e-26	1	0	T	78189539	T	T	78189539	3	4	2	1	0	0	0	0	1	0	0	0	14943	1319	46	4	511	4	SNW1	14	78189539	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	486481	78189539	29160001	158	333											
NRXN3	9369	broad.mit.edu	37	chr14	79933679	79933679	+	Frame_Shift_Del	DEL	G	-	-																															gtgggcttcagcaccactgtGaaggatggcatcttggtccg																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr14:79933679delG	uc001xun.2	+	13	2750	c.2259delG	c.(2257-2259)GTGfs	p.V753fs	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Frame_Shift_Del_p.V121fs|NRXN3_uc010asw.2_Frame_Shift_Del_p.V121fs|NRXN3_uc001xur.3_Frame_Shift_Del_p.V121fs	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1126	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCACCACTGTGAAGGATGGCA	0.562													---	---	---								-	79933679	-	-	79933679	7	5	2	1	0	1	0	1	0	0	0	0	10721	1277	45	0	2552	0	NRXN3	14	79933679	Frame_Shift_Del	DEL	G	TCGA-BA-4075-01A-01D-1434-08	1744140	79933679	27415861	159	334											
BRF1	2972	broad.mit.edu	37	chr14	105686450	105686450	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccactgaggtccagctcacCgtctcctgaagcatcttctg	7	10	9	15	1	4	2	1	2	3	0	6	2	5	2	4	1	2	2	4	1	1	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr14:105686450C>T	uc001yqp.2	-	12	1696	c.1333G>A	c.(1333-1335)GGT>AGT	p.G445S	BRF1_uc010tyo.1_Missense_Mutation_p.G330S|BRF1_uc010typ.1_Missense_Mutation_p.G330S|BRF1_uc001yqk.2_5'UTR|BRF1_uc001yql.2_Missense_Mutation_p.G241S|BRF1_uc001yqo.2_Missense_Mutation_p.G207S|BRF1_uc010axg.1_Missense_Mutation_p.G418S|BRF1_uc001yqn.2_Intron|BRF1_uc010axh.1_Intron|BRF1_uc010axi.1_5'UTR	NM_001519	NP_001510	Q92994	TF3B_HUMAN	transcription initiation factor IIIB isoform 1	445					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		TCCAGCTCACCGTCTCCTGAA	0.627													8	120					0	0	0	0	T	105686450	T	T	105686450	3	4	2	1	0	0	0	0	1	0	0	0	1515	652	23	1	728	1	BRF1	14	105686450	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	25752771	105686450	1663090	160	335											
GABRG3	2567	broad.mit.edu	37	chr15	27772605	27772605	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacggtgctgaccatgaccAccctgagcaccatcgccagg	9	5	10	17	2	0	3	0	3	0	0	1	3	0	3	6	2	2	2	6	2	0	0			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr15:27772605A>G	uc001zbg.1	+	8	1058	c.892A>G	c.(892-894)ACC>GCC	p.T298A		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	298	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		GACCATGACCACCCTGAGCAC	0.582													11	86					0	0	0	0	G	27772605	G	G	27772605	3	3	2	1	0	0	0	0	1	0	0	0	6207	159	6	5	922	5	GABRG3	15	27772605	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08		27772605	74758787	161	336											
GLDN	342035	broad.mit.edu	37	chr15	51696666	51696666	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caactggatgagaggacattCtcagtggtgcaacacgtcaa	13	8	11	9	1	2	1	2	1	1	1	3	4	2	3	0	3	3	1	0	3	3	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr15:51696666C>T	uc002aba.2	+	10	1540	c.1371C>T	c.(1369-1371)TTC>TTT	p.F457F	GLDN_uc002abb.2_Silent_p.F333F	NM_181789	NP_861454	Q6ZMI3	GLDN_HUMAN	gliomedin	457	Extracellular (Potential).|Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		AGAGGACATTCTCAGTGGTGC	0.473													13	158					0	0	0	0	T	51696666	T	T	51696666	2	4	2	1	0	0	0	0	0	0	0	1	6471	912	32	2		2	GLDN	15	51696666	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	23924061	51696666	50834726	162	337											
GCOM1	145781	broad.mit.edu	37	chr15	57925871	57925871	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaaaagatgcaagcagcaGagatcagcctagaggagaaa	20	4	11	6	0	1	4	1	0	0	4	1	6	1	4	1	1	4	3	1	1	6	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr15:57925871G>T	uc002aei.2	+	8	984	c.865G>T	c.(865-867)GAG>TAG	p.E289*	GCOM1_uc002aej.2_Nonsense_Mutation_p.E289*|GCOM1_uc002aek.2_RNA|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Nonsense_Mutation_p.E289*|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Nonsense_Mutation_p.E289*|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	289	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						GCAAGCAGCAGAGATCAGCCT	0.473													5	139					0.000157383	0.000170793	1	0	T	57925871	T	T	57925871	4	4	2	1	0	0	0	0	0	1	0	0	6340	943	33	2	895	2	GCOM1	15	57925871	Nonsense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	6229205	57925871	44605521	163	338											
LINGO1	84894	broad.mit.edu	37	chr15	77907760	77907760	+	Frame_Shift_Del	DEL	A	-	-																															ttgaggttgtacaggtcctgAaacatgtagtccagtaggat																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr15:77907760delA	uc002bct.1	-	2	541	c.489delT	c.(487-489)TTTfs	p.F163fs	LINGO1_uc002bcu.1_Frame_Shift_Del_p.F157fs	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	163	Extracellular (Potential).|LRR 4.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						ACAGGTCCTGAAACATGTAGT	0.552													---	---	---								-	77907760	-	-	77907760	7	5	2	1	0	1	0	1	0	0	0	0	8856	243	9	0	1377	0	LINGO1	15	77907760	Frame_Shift_Del	DEL	A	TCGA-BA-4075-01A-01D-1434-08	19981889	77907760	24623632	164	339											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84651068	84651068	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaacttggtgagcagggtccGcagatcctcagtgtccagag	10	8	13	10	1	1	3	1	1	0	2	4	3	4	3	3	2	2	2	3	2	1	1	rs139222116		TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr15:84651068G>T	uc002bjz.3	+	21	2912	c.2688G>T	c.(2686-2688)CCG>CCT	p.P896P	ADAMTSL3_uc010bmt.1_Silent_p.P896P|ADAMTSL3_uc010bmu.1_Silent_p.P896P	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	896	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCAGGGTCCGCAGATCCTCA	0.403													9	97					1.12685e-05	1.25667e-05	1	0	T	84651068	T	T	84651068	2	4	2	1	0	0	0	0	0	0	0	1	276	1074	38	3		3	ADAMTSL3	15	84651068	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	6743308	84651068	17880324	165	340											
LITAF	9516	broad.mit.edu	37	chr16	11650451	11650451	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atcaggccccgtcacaagccCcgtagttggcccaggcatgg	8	6	12	15	2	2	0	2	0	0	0	2	0	2	0	5	4	1	3	5	4	2	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr16:11650451C>T	uc002daz.2	-	2	369	c.136G>A	c.(136-138)GGG>AGG	p.G46R	LITAF_uc002dba.2_Missense_Mutation_p.G46R|LITAF_uc002dbb.2_Missense_Mutation_p.G46R|LITAF_uc002dbc.2_Missense_Mutation_p.G46R|LITAF_uc002dbd.2_Missense_Mutation_p.G46R|LITAF_uc002dbe.3_Missense_Mutation_p.G46R	NM_004862	NP_004853	Q99732	LITAF_HUMAN	lipopolysaccharide-induced TNF-alpha factor	46					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|lysosomal membrane	signal transducer activity|WW domain binding			liver(1)	1						GTCACAAGCCCCGTAGTTGGC	0.567													4	106					0	0	0	0	T	11650451	T	T	11650451	3	4	2	1	0	0	0	0	1	0	0	0	8872	623	22	4	447	4	LITAF	16	11650451	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08		11650451	78704302	166	341											
DNAH3	55567	broad.mit.edu	37	chr16	21014470	21014470	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctctttggtgatatactGtgtccacgtttcccaatgtc	6	16	7	12	1	1	1	0	1	1	0	5	1	4	1	3	1	1	1	3	1	3	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr16:21014470G>A	uc010vbe.1	-	42	6082	c.6082C>T	c.(6082-6084)CAG>TAG	p.Q2028*		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2028					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GTGATATACTGTGTCCACGTT	0.388													64	202					0	0	0	0	A	21014470	A	A	21014470	4	1	2	1	0	0	0	0	0	1	0	0	4625	1386	48	4	6351	4	DNAH3	16	21014470	Nonsense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	9364019	21014470	69340283	167	342											
CENPT	80152	broad.mit.edu	37	chr16	67865119	67865119	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggggaaaacccaaccttacTtggaggagccagggaagtat	14	6	13	8	0	0	0	0	0	0	0	0	4	0	4	3	5	4	1	3	5	6	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr16:67865119T>A	uc002eun.3	-	10	1252	c.703A>T	c.(703-705)AAC>TAC	p.N235Y	CENPT_uc002eum.3_Missense_Mutation_p.N235Y|CENPT_uc010vkc.1_5'UTR|CENPT_uc010vkd.1_5'UTR|CENPT_uc010vke.1_Missense_Mutation_p.S132C	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	235					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		CCAACCTTACTTGGAGGAGCC	0.612													6	283					0	0	0	0	A	67865119	A	A	67865119	3	1	2	1	0	0	0	0	1	0	0	0	3257	1623	56	5	1010	5	CENPT	16	67865119	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	46850649	67865119	22489634	168	343											
TERF2	7014	broad.mit.edu	37	chr16	69419369	69419369	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggacacggtgtgctccttccCcaagggcctgacaagcaaag	10	6	12	13	1	0	1	0	1	0	0	2	2	2	2	4	3	2	2	4	3	3	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr16:69419369C>T	uc002exd.2	-	2	399	c.274G>A	c.(274-276)GGG>AGG	p.G92R	TERF2_uc002exe.2_Missense_Mutation_p.G92R	NM_005652	NP_005643	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	92	TRFH dimerization.				age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			lung(1)	1		Ovarian(137;0.101)				TGCTCCTTCCCCAAGGGCCTG	0.587													8	216					0	0	0	0	T	69419369	T	T	69419369	3	4	2	1	0	0	0	0	1	0	0	0	15828	623	22	4	1264	4	TERF2	16	69419369	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	1554250	69419369	20935384	169	344											
ZNF19	7567	broad.mit.edu	37	chr16	71509834	71509834	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtgtgaatcctctggtgccGaattaacgaagaattaccat	13	11	9	8	2	1	2	0	1	1	1	2	4	2	2	3	1	3	0	3	1	6	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr16:71509834G>A	uc010cgc.1	-	6	1122	c.616C>T	c.(616-618)CGG>TGG	p.R206W	ZNF23_uc002fai.2_Intron|ZNF19_uc002fak.1_Missense_Mutation_p.R194W|ZNF19_uc002fal.1_Missense_Mutation_p.R194W|ZNF19_uc002fam.1_Missense_Mutation_p.R206W	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	206	C2H2-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		CTCTGGTGCCGAATTAACGAA	0.443													46	41					0	0	0	0	A	71509834	A	A	71509834	3	1	2	1	0	0	0	0	1	0	0	0	17822	1057	37	1	764	1	ZNF19	16	71509834	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	2090465	71509834	18844919	170	345											
ATP2C2	9914	broad.mit.edu	37	chr16	84492949	84492949	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccctcaacgccatgcagAtcctatggatcaacatcatc	11	8	6	16	1	3	1	3	0	0	1	5	2	4	2	4	1	3	1	4	1	3	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr16:84492949A>G	uc002fhx.2	+	23	2379	c.2290A>G	c.(2290-2292)ATC>GTC	p.I764V	ATP2C2_uc010chj.2_Missense_Mutation_p.I764V|ATP2C2_uc002fhy.2_Missense_Mutation_p.I781V|ATP2C2_uc002fhz.2_Missense_Mutation_p.I613V|ATP2C2_uc002fia.2_5'Flank	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	764	Helical; Name=6; (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						CGCCATGCAGATCCTATGGAT	0.637													69	122					0	0	0	0	G	84492949	G	G	84492949	3	3	2	1	0	0	0	0	1	0	0	0	1146	333	12	5	2380	5	ATP2C2	16	84492949	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	12983115	84492949	5861804	171	346											
TSR1	55720	broad.mit.edu	37	chr17	2234293	2234293	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttaaagatgcttttcctaGtgttagtaaagttctgaaac	12	16	7	6	0	1	2	0	1	1	1	2	2	2	2	1	0	2	4	1	0	7	8			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr17:2234293G>C	uc002fuj.2	-	9	2564	c.1607C>G	c.(1606-1608)ACT>AGT	p.T536S	SNORD91B_uc002fuk.1_5'Flank|SNORD91A_uc002ful.1_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	536					ribosome assembly	nucleolus	protein binding			ovary(1)	1						GCTTTTCCTAGTGTTAGTAAA	0.393													14	130					0	0	0	0	C	2234293	C	C	2234293	3	2	2	1	0	0	0	0	1	0	0	0	16731	1029	36	4	835	4	TSR1	17	2234293	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08		2234293	78960917	172	347											
TP53	7157	broad.mit.edu	37	chr17	7577017	7577017	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcttcttgtcctgcttgcttAcctcgcttagtgctccctgg	2	16	9	14	1	1	0	0	0	1	0	4	0	3	0	3	1	4	5	3	1	2	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr17:7577017A>C	uc002gim.2	-	8	1113	c.919_splice	c.e8+1	p.A307_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.A307_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.A175_splice|TP53_uc010cng.1_Splice_Site_p.A175_splice|TP53_uc002gii.1_Splice_Site_p.A175_splice|TP53_uc010cnh.1_Splice_Site_p.A307_splice|TP53_uc010cni.1_Splice_Site_p.A307_splice|TP53_uc002gij.2_Splice_Site_p.A307_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(6)|p.A307fs*34(1)|p.L308fs*31(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTGCTTGCTTACCTCGCTTAG	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			119	66					0	0	0	0	C	7577017	C	C	7577017	5	2	2	1	0	0	0	0	0	0	1	0	16448	405	14	5	365	5	TP53	17	7577017	Splice_Site	SNP	A	TCGA-BA-4075-01A-01D-1434-08	5342724	7577017	73618193	173	348											
KCNAB3	9196	broad.mit.edu	37	chr17	7829006	7829007	+	Frame_Shift_Ins	INS	-	T	T																															cccctaactctcaccctcaaINStgatgtgctttcggcttaaa																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr17:7829006_7829007insT	uc002gjm.1	-	7	532_533	c.532_533insA	c.(532-534)ATTfs	p.I178fs	KCNAB3_uc010vul.1_RNA	NM_004732	NP_004723	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related	178						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(1)	1		Prostate(122;0.157)				CTCACCCTCAATGATGTGCTTT	0.5													---	---	---								T	7829007	T	T	7829006	7	5	2	1	0	1	1	0	0	0	0	0	8050	101	4	0	713	0	KCNAB3	17	7829006	Frame_Shift_Ins	INS	-	TCGA-BA-4075-01A-01D-1434-08	251989	7829006	73366204	174	349											
GLP2R	9340	broad.mit.edu	37	chr17	9739771	9739771	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctctgtaccctgcccttcaTacttaccttggtggagtgaa	7	14	8	12	0	2	1	1	1	1	0	3	2	2	2	3	2	4	1	3	2	4	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr17:9739771T>C	uc002gmd.1	+	3	361	c.361T>C	c.(361-363)TAC>CAC	p.Y121H	GLP2R_uc010cog.1_RNA	NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	121	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	CTGCCCTTCATACTTACCTTG	0.448													96	214					0	0	0	0	C	9739771	C	C	9739771	3	2	2	1	0	0	0	0	1	0	0	0	6490	1406	49	5	371	5	GLP2R	17	9739771	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08	1910765	9739771	71455439	175	350											
MYH13	8735	broad.mit.edu	37	chr17	10233707	10233707	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgagggtctgtgtcacctcCtctccatcatcttcttgaac	6	14	8	13	0	6	2	2	2	4	0	8	2	7	2	3	1	1	0	3	1	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr17:10233707C>T	uc002gmk.1	-	21	2522	c.2432G>A	c.(2431-2433)AGG>AAG	p.R811K		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	811	IQ.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GTGTCACCTCCTCTCCATCAT	0.537													3	31					0	0	0	0	T	10233707	T	T	10233707	3	4	2	1	0	0	0	0	1	0	0	0	10085	681	24	4	3468	4	MYH13	17	10233707	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	493936	10233707	70961503	176	351											
TTC19	54902	broad.mit.edu	37	chr17	15929998	15929998	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggtactcagtaatctagctGcagttttgatgcacagaggt	10	13	11	7	0	2	2	1	1	1	1	2	2	2	2	0	2	4	6	0	2	3	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr17:15929998G>A	uc002gph.1	+	9	1357	c.1339G>A	c.(1339-1341)GCA>ACA	p.A447T	TTC19_uc010cox.1_RNA|TTC19_uc002gpk.3_Missense_Mutation_p.A89T|TTC19_uc002gpj.2_Missense_Mutation_p.A89T	NM_017775	NP_060245	Q6DKK2	TTC19_HUMAN	tetratricopeptide repeat domain 19	326	TPR 5.				cell cycle|cytokinesis|mitochondrial respiratory chain complex III assembly	centrosome|midbody|mitochondrial inner membrane	protein binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TAATCTAGCTGCAGTTTTGAT	0.428													16	108					0	0	0	0	A	15929998	A	A	15929998	3	1	2	1	0	0	0	0	1	0	0	0	16754	1319	46	4	1373	4	TTC19	17	15929998	Missense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08	5696291	15929998	65265212	177	352											
SYNRG	11276	broad.mit.edu	37	chr17	35913812	35913812	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccaaaaaggctgaattcTccaaaatcatcagccaaact	16	8	4	13	0	3	1	2	1	1	0	5	1	4	1	4	1	2	1	4	1	6	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr17:35913812T>A	uc002hoa.2	-	14	2096	c.2013A>T	c.(2011-2013)GGA>GGT	p.G671G	SYNRG_uc010wde.1_Silent_p.G593G|SYNRG_uc010wdf.1_Silent_p.G593G|SYNRG_uc002hoc.2_Silent_p.G592G|SYNRG_uc002hoe.2_Silent_p.G593G|SYNRG_uc002hod.2_Silent_p.G593G|SYNRG_uc010wdg.1_Silent_p.G510G|SYNRG_uc002hob.2_Silent_p.G671G|SYNRG_uc002hof.2_Silent_p.G383G|SYNRG_uc010cvd.1_Silent_p.G471G	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	671	Interaction with A1P1G1 and A1P1G2.				endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						GGCTGAATTCTCCAAAATCAT	0.418													66	36					0	0	0	0	A	35913812	A	A	35913812	2	1	2	1	0	0	0	0	0	0	0	1	15526	1538	54	5		5	SYNRG	17	35913812	Silent	SNP	T	TCGA-BA-4075-01A-01D-1434-08	19983814	35913812	45281398	178	353											
RAPGEFL1	51195	broad.mit.edu	37	chr17	38340838	38340838	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcctcctctctccaggatctAtacctgctaattatgaagga	10	13	6	12	0	2	1	0	1	2	0	6	3	5	3	4	2	2	1	4	2	5	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr17:38340838A>G	uc010cwu.1	+	4	613	c.123A>G	c.(121-123)CTA>CTG	p.L41L		NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor	247					G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TCCAGGATCTATACCTGCTAA	0.552													3	15					0	0	0	0	G	38340838	G	G	38340838	2	3	2	1	0	0	0	0	0	0	0	1	13114	436	16	5		5	RAPGEFL1	17	38340838	Silent	SNP	A	TCGA-BA-4075-01A-01D-1434-08	2427026	38340838	42854372	179	354											
LUC7L3	51747	broad.mit.edu	37	chr17	48823139	48823139	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgagcgtctaaaaaaggagaAgcaagaaagagaagaaagag	22	3	13	3	1	1	6	0	1	1	5	1	8	1	6	0	1	2	1	0	1	8	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr17:48823139A>T	uc002isr.2	+	8	869	c.752A>T	c.(751-753)AAG>ATG	p.K251M	LUC7L3_uc010wmw.1_Missense_Mutation_p.K175M|LUC7L3_uc002isq.2_Missense_Mutation_p.K251M|LUC7L3_uc002iss.2_Missense_Mutation_p.K251M	NM_006107	NP_006098	O95232	LC7L3_HUMAN	LUC7-like 3	251	Arg/Ser-rich.|Glu-rich.				apoptosis|mRNA processing|response to stress|RNA splicing	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding				0						AAAAAGGAGaagcaagaaaga	0.184													5	13					0	0	0	0	T	48823139	T	T	48823139	3	4	2	1	0	0	0	0	1	0	0	0	9134	72	3	5	782	5	LUC7L3	17	48823139	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	10482301	48823139	32372071	180	355											
RNF213	57674	broad.mit.edu	37	chr17	78338337	78338338	+	Missense_Mutation	DNP	TC	AT	AT																															ggggctggtgaccgagcacgTcttcttactagacaaggtga																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr17:78338337_78338338TC>AT	uc002jyh.1	+	17	6297_6298	c.6074_6075TC>AT	c.(6073-6075)GTC>GAT	p.V2025D	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.V407D	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ACCGAGCACGTCTTCTTACTAG	0.579													13	62					0	0	0	0	AT	78338338	AT	AT	78338337	3	1	2	1	0	0	0	0	1	0	0	0	13542	1667	58	5	12336	5	RNF213	17	78338337	Missense_Mutation	DNP	TC	TCGA-BA-4075-01A-01D-1434-08	29515198	78338337	2856873	181	356											
ANKRD30B	374860	broad.mit.edu	37	chr18	14787090	14787090	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gacgatgaagaaaattcttgGgattctgaggtactatgtgt	12	13	12	4	1	2	3	0	2	2	1	2	6	2	4	0	2	1	1	0	2	5	5			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr18:14787090G>A	uc010dlo.2	+	15	1905	c.1725G>A	c.(1723-1725)TGG>TGA	p.W575*	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	575										ovary(1)|skin(1)	2						AAAATTCTTGGGATTCTGAGG	0.318													3	47					0	0	0	0	A	14787090	A	A	14787090	4	1	2	1	0	0	0	0	0	1	0	0	659	1241	43	4	1783	4	ANKRD30B	18	14787090	Nonsense_Mutation	SNP	G	TCGA-BA-4075-01A-01D-1434-08		14787090	63290158	182	357											
ASXL3	80816	broad.mit.edu	37	chr18	31323177	31323177	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctcgagcccatctcttccAgacctctaaagagacccggt	10	8	8	15	2	2	2	0	0	2	2	5	4	3	2	4	1	2	1	4	1	2	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr18:31323177A>G	uc010dmg.1	+	12	3420	c.3365A>G	c.(3364-3366)CAG>CGG	p.Q1122R	ASXL3_uc002kxq.2_Missense_Mutation_p.Q829R	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1122					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CATCTCTTCCAGACCTCTAAA	0.507													3	32					0	0	0	0	G	31323177	G	G	31323177	3	3	2	1	0	0	0	0	1	0	0	0	1070	188	7	5	3411	5	ASXL3	18	31323177	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	16536087	31323177	46754071	183	358											
SERPINB4	6318	broad.mit.edu	37	chr18	61305189	61305189	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaggtcatgcctgagaggtCtgcatccccattgaagatat	10	10	10	11	0	2	3	1	2	1	2	3	4	3	3	4	2	2	1	4	2	2	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr18:61305189C>G	uc002ljf.2	-	8	1023	c.937G>C	c.(937-939)GAC>CAC	p.D313H	SERPINB4_uc002lje.2_Missense_Mutation_p.D292H|SERPINB4_uc002ljg.2_Missense_Mutation_p.D313H	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	313					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						CCTGAGAGGTCTGCATCCCCA	0.502													4	73					0	0	0	0	G	61305189	G	G	61305189	3	3	2	1	0	0	0	0	1	0	0	0	14168	913	32	2	239	2	SERPINB4	18	61305189	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	29982012	61305189	16772059	184	359											
ZNF493	284443	broad.mit.edu	37	chr19	21607117	21607117	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaatgtgaagaatgtggcaaAgcttttaatcggtcctcaca	14	11	9	7	1	1	2	1	1	0	1	3	2	2	2	1	2	1	2	1	2	5	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr19:21607117A>T	uc002npx.2	+	2	1552	c.1272A>T	c.(1270-1272)AAA>AAT	p.K424N	ZNF493_uc002npw.2_Missense_Mutation_p.K552N|ZNF493_uc002npy.2_Missense_Mutation_p.K424N	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	424	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AATGTGGCAAAGCTTTTAATC	0.363													15	62					0	0	0	0	T	21607117	T	T	21607117	3	4	2	1	0	0	0	0	1	0	0	0	18011	69	3	5	1733	5	ZNF493	19	21607117	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08		21607117	37521866	185	360											
RYR1	6261	broad.mit.edu	37	chr19	38960132	38960132	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccagtttgagccagtgccCcttgaacaccctcactatga	9	9	7	16	0	1	3	1	3	0	0	1	3	1	3	6	0	3	1	6	0	2	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr19:38960132C>T	uc002oit.2	+	27	3874	c.3744C>T	c.(3742-3744)CCC>CCT	p.P1248P	RYR1_uc002oiu.2_Silent_p.P1248P	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1248	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGCCAGTGCCCCTTGAACACC	0.552													5	150					0	0	0	0	T	38960132	T	T	38960132	2	4	2	1	0	0	0	0	0	0	0	1	13833	610	22	4		4	RYR1	19	38960132	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	17353015	38960132	20168851	186	361											
ITPKC	80271	broad.mit.edu	37	chr19	41223266	41223267	+	Frame_Shift_Ins	INS	-	T	T																															cgagcctgagagggccggccINStcgggcctgcgccggggaca																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr19:41223266_41223267insT	uc002oot.2	+	1	259_260	c.226_227insT	c.(226-228)CTCfs	p.L76fs	ADCK4_uc002ooq.1_5'Flank|ADCK4_uc002oor.2_5'Flank|ADCK4_uc002oos.2_5'Flank	NM_025194	NP_079470	Q96DU7	IP3KC_HUMAN	inositol 1,4,5-trisphosphate 3-kinase C	76						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GAGGGCCGGCCTCGGGCCTGCG	0.49													---	---	---								T	41223267	T	T	41223266	7	5	2	1	0	1	1	0	0	0	0	0	7958	681	24	0	228	0	ITPKC	19	41223266	Frame_Shift_Ins	INS	-	TCGA-BA-4075-01A-01D-1434-08	2263134	41223266	17905717	187	362											
PSG3	5671	broad.mit.edu	37	chr19	43237075	43237075	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggacaactgcaagctgtgAgtcatagggaggctctgacc	10	9	13	9	0	2	2	1	2	1	0	2	4	2	4	1	3	3	3	1	3	3	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr19:43237075A>T	uc002oue.2	-	3	702	c.570T>A	c.(568-570)ACT>ACA	p.T190T	PSG3_uc002ouf.2_RNA|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Silent_p.T212T	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	190	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				GCAAGCTGTGAGTCATAGGGA	0.502													128	302					0	0	0	0	T	43237075	T	T	43237075	2	4	2	1	0	0	0	0	0	0	0	1	12718	291	11	5		5	PSG3	19	43237075	Silent	SNP	A	TCGA-BA-4075-01A-01D-1434-08	2013809	43237075	15891908	188	363											
CPT1C	126129	broad.mit.edu	37	chr19	50210775	50210775	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctgaactctccctgacagCtggtttgacaaatccttcac	10	12	6	13	0	3	3	1	3	2	0	5	3	4	3	2	1	2	2	2	1	2	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr19:50210775C>T	uc002ppj.2	+	12	1549	c.1344C>T	c.(1342-1344)CGC>CGT	p.R448R	CPT1C_uc002ppl.3_Silent_p.R414R|CPT1C_uc002ppi.2_Silent_p.R365R|CPT1C_uc002ppk.2_Silent_p.R437R|CPT1C_uc010eng.2_Silent_p.R448R|CPT1C_uc010enh.2_Silent_p.R448R|CPT1C_uc010ybc.1_Silent_p.R319R|CPT1C_uc010eni.1_Silent_p.R105R	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	448	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TCCCTGACAGCTGGTTTGACA	0.562													4	56					0	0	0	0	T	50210775	T	T	50210775	2	4	2	1	0	0	0	0	0	0	0	1	3848	811	28	4		4	CPT1C	19	50210775	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	6973700	50210775	8918208	189	364											
ZNF417	147687	broad.mit.edu	37	chr19	58420413	58420413	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaatgatttcccacattcCttgcactcatagggcctttc	9	14	5	13	0	1	1	1	1	0	0	4	1	3	1	3	1	1	1	3	1	3	6			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr19:58420413C>T	uc002qqq.2	-	3	1432	c.1233G>A	c.(1231-1233)AAG>AAA	p.K411K	ZNF417_uc010yhm.1_Silent_p.K368K|ZNF417_uc002qqr.2_Silent_p.K410K	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	411	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		TCCCACATTCCTTGCACTCAT	0.453													6	177					0	0	0	0	T	58420413	T	T	58420413	2	4	2	1	0	0	0	0	0	0	0	1	17961	680	24	4		4	ZNF417	19	58420413	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	8209638	58420413	708570	190	365											
FASTKD5	60493	broad.mit.edu	37	chr20	3128841	3128841	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attaggtcctgggatacctgAcgattttcacctataacata	12	13	7	9	1	1	1	1	1	0	0	2	3	2	2	3	2	2	0	3	2	5	7			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr20:3128841A>C	uc002whz.2	-	2	1187	c.876T>G	c.(874-876)CGT>CGG	p.R292R	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	292					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						GGGATACCTGACGATTTTCAC	0.343													14	150					0	0	0	0	C	3128841	C	C	3128841	2	2	2	1	0	0	0	0	0	0	0	1	5720	262	10	5		5	FASTKD5	20	3128841	Silent	SNP	A	TCGA-BA-4075-01A-01D-1434-08		3128841	59896679	191	366											
NAA20	51126	broad.mit.edu	37	chr20	20013236	20013236	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagcagttgggctacagtgtAtataggacggtcatagagta	13	10	13	5	1	1	1	1	0	0	1	1	2	1	2	0	3	2	5	0	3	7	7			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr20:20013236A>T	uc002wrp.2	+	5	494	c.390A>T	c.(388-390)GTA>GTT	p.V130V	NAA20_uc002wrq.2_Intron|NAA20_uc002wrr.2_Silent_p.V118V	NM_016100	NP_057184	P61599	NAA20_HUMAN	N-acetyltransferase 5 isoform a	130	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity				0						GCTACAGTGTATATAGGACGG	0.438													12	62					0	0	0	0	T	20013236	T	T	20013236	2	4	2	1	0	0	0	0	0	0	0	1	10173	436	16	5		5	NAA20	20	20013236	Silent	SNP	A	TCGA-BA-4075-01A-01D-1434-08	16884395	20013236	43012284	192	367											
EMILIN3	90187	broad.mit.edu	37	chr20	39990016	39990016	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgggccagcgtacgattCagctggtccacatggctcca	7	9	12	13	2	1	0	1	0	0	0	3	1	3	0	3	3	4	4	3	3	1	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr20:39990016C>T	uc002xjy.1	-	4	2417	c.2193G>A	c.(2191-2193)CTG>CTA	p.L731L		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	731	Potential.					proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				GCGTACGATTCAGCTGGTCCA	0.687													26	34					0	0	0	0	T	39990016	T	T	39990016	2	4	2	1	0	0	0	0	0	0	0	1	5119	813	29	2		2	EMILIN3	20	39990016	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	19976780	39990016	23035504	193	368											
RBM11	54033	broad.mit.edu	37	chr21	15585612	15585613	+	5'Flank	INS	-	TTCC	TTCC																															tagtagttggccaacctcctINSttccttccttccttccttcc																								rs145138104	by1000genomes	TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr21:15585612_15585613insTTCC	uc002yjo.3	+						RBM11_uc002yjn.3_5'Flank|RBM11_uc002yjp.3_5'Flank	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11								nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		GCCAAcctcctttccttccttc	0.144													---	---	---								TTCC	15585613	TTCC	TTCC	15585612	6	5	2	0	1	1	1	0	0	0	0	0	13177	1624	56	0		0	RBM11	21	15585612	5'Flank	INS	-	TCGA-BA-4075-01A-01D-1434-08		15585612	32544283	194	369											
CLDN17	26285	broad.mit.edu	37	chr21	31538876	31538876	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agaagggttgtggcaagagtCcccaccatgccaaggaaccc	12	5	12	12	0	0	2	0	0	0	2	1	3	1	3	5	3	2	2	5	3	4	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr21:31538876C>T	uc011acv.1	-	1	60	c.60G>A	c.(58-60)GGG>GGA	p.G20G		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	20	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2						TGGCAAGAGTCCCCACCATGC	0.478													36	91					0	0	0	0	T	31538876	T	T	31538876	2	4	2	1	0	0	0	0	0	0	0	1	3493	842	30	2		2	CLDN17	21	31538876	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	15953264	31538876	16591019	195	370											
UMODL1	89766	broad.mit.edu	37	chr21	43529775	43529775	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgccgtaccaccagggaCgccaccccctcccgcgcagg	7	3	11	20	4	0	0	0	0	0	0	1	1	1	1	7	2	2	2	7	2	1	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr21:43529775C>T	uc002zaf.1	+	10	1623	c.1623C>T	c.(1621-1623)GAC>GAT	p.D541D	UMODL1_uc002zad.1_Silent_p.D469D|UMODL1_uc002zae.1_Silent_p.D469D|UMODL1_uc002zag.1_Silent_p.D541D|C21orf128_uc002zak.2_5'Flank	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	541	EGF-like 2; calcium-binding (Potential).|Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CCACCAGGGACGCCACCCCCT	0.687													4	47					0	0	0	0	T	43529775	T	T	43529775	2	4	2	1	0	0	0	0	0	0	0	1	17048	535	19	1		1	UMODL1	21	43529775	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	11990899	43529775	4600120	196	371											
GCAT	23464	broad.mit.edu	37	chr22	38209492	38209492	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgctgaccccagaggacgCagtcctgtcggacgagctga	8	6	13	14	3	0	3	0	2	0	1	2	6	1	5	4	2	2	3	4	2	0	0			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr22:38209492C>T	uc003atz.2	+	4	472	c.452C>T	c.(451-453)GCA>GTA	p.A151V	GCAT_uc003aua.1_Missense_Mutation_p.A177V	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	151					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CCAGAGGACGCAGTCCTGTCG	0.607													5	14					0	0	0	0	T	38209492	T	T	38209492	3	4	2	1	0	0	0	0	1	0	0	0	6319	710	25	4	544	4	GCAT	22	38209492	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08		38209492	13095074	197	372											
SUN2	25777	broad.mit.edu	37	chr22	39141797	39141797	+	Frame_Shift_Del	DEL	G	-	-																															tggaatgtctgcagcccataGgggtagaaataccaagcacc																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr22:39141797delG	uc003awh.1	-	9	989	c.705delC	c.(703-705)CCCfs	p.P235fs	SUN2_uc011anz.1_Frame_Shift_Del_p.P270fs|SUN2_uc011aoa.1_Frame_Shift_Del_p.P224fs|SUN2_uc003awi.1_Frame_Shift_Del_p.P235fs|SUN2_uc010gxq.1_Frame_Shift_Del_p.P256fs|SUN2_uc010gxr.1_Frame_Shift_Del_p.P235fs|SUN2_uc010gxs.1_Frame_Shift_Del_p.P235fs	NM_015374	NP_056189	Q9UH99	SUN2_HUMAN	unc-84 homolog B	235	Perinuclear space.				centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			large_intestine(1)|skin(1)	2						GCAGCCCATAGGGGTAGAAAT	0.622													---	---	---								-	39141797	-	-	39141797	7	5	2	1	0	1	0	1	0	0	0	0	15458	987	35	0	1492	0	SUN2	22	39141797	Frame_Shift_Del	DEL	G	TCGA-BA-4075-01A-01D-1434-08	932305	39141797	12162769	198	373											
TNRC6B	23112	broad.mit.edu	37	chr22	40660900	40660900	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accgataacaacagtgcctcGaaccctggctctgagaagag	13	6	10	12	2	1	2	0	1	1	2	2	5	1	2	3	1	4	1	3	1	4	1			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr22:40660900G>A	uc011aor.1	+	5	877	c.666G>A	c.(664-666)TCG>TCA	p.S222S	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Silent_p.S222S|TNRC6B_uc003ayo.2_Silent_p.S26S	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	222					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						ACAGTGCCTCGAACCCTGGCT	0.498													55	105					0	0	0	0	A	40660900	A	A	40660900	2	1	2	1	0	0	0	0	0	0	0	1	16407	1045	37	1		1	TNRC6B	22	40660900	Silent	SNP	G	TCGA-BA-4075-01A-01D-1434-08	1519103	40660900	10643666	199	374											
EP300	2033	broad.mit.edu	37	chr22	41545804	41545804	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgcccggtgaactctcctAtaatgcctccagggtctcag	7	10	9	15	1	2	1	1	1	2	0	5	1	3	1	5	2	3	0	5	2	3	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr22:41545804A>G	uc003azl.3	+	14	2814	c.2419A>G	c.(2419-2421)ATA>GTA	p.I807V		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	807					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GAACTCTCCTATAATGCCTCC	0.458			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				21	50					0	0	0	0	G	41545804	G	G	41545804	3	3	2	1	0	0	0	0	1	0	0	0	5172	449	16	5	2473	5	EP300	22	41545804	Missense_Mutation	SNP	A	TCGA-BA-4075-01A-01D-1434-08	884904	41545804	9758762	200	375											
NUP50	10762	broad.mit.edu	37	chr22	45579372	45579372	+	Frame_Shift_Del	DEL	A	-	-																															tacagcaaatcagaagacacAgcttttggtgcgggcagaca																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chr22:45579372delA	uc003bfr.2	+	7	1637	c.1175delA	c.(1174-1176)CAGfs	p.Q392fs	NUP50_uc003bfs.2_Frame_Shift_Del_p.Q364fs|NUP50_uc011aqn.1_Frame_Shift_Del_p.Q142fs|NUP50_uc003bft.2_Frame_Shift_Del_p.Q364fs|NUP50_uc011aqo.1_Frame_Shift_Del_p.Q142fs	NM_007172	NP_009103	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa isoform b	392	RanBD1.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CAGAAGACACAGCTTTTGGTG	0.383													---	---	---								-	45579372	-	-	45579372	7	5	2	1	0	1	0	1	0	0	0	0	10820	188	7	0	1197	0	NUP50	22	45579372	Frame_Shift_Del	DEL	A	TCGA-BA-4075-01A-01D-1434-08	4033568	45579372	5725194	201	376											
SH3KBP1	30011	broad.mit.edu	37	chrX	19555888	19555888	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caactcagacaataactgttTaatctctcgtctgaaaagca	15	11	5	10	1	3	2	1	1	2	1	5	2	3	2	0	0	3	2	0	0	6	3			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chrX:19555888T>G	uc004czm.2	-	17	2219	c.1903A>C	c.(1903-1905)AAA>CAA	p.K635Q	SH3KBP1_uc011mje.1_Missense_Mutation_p.K374Q|SH3KBP1_uc011mjf.1_Missense_Mutation_p.K397Q|SH3KBP1_uc004czl.2_Missense_Mutation_p.K598Q|SH3KBP1_uc010nfm.2_Missense_Mutation_p.K80Q	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	635	Potential.				apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						AATAACTGTTTAATCTCTCGT	0.438													61	27					0	0	0	0	G	19555888	G	G	19555888	3	3	2	1	0	0	0	0	1	0	0	0	14320	1763	61	5	102	5	SH3KBP1	23	19555888	Missense_Mutation	SNP	T	TCGA-BA-4075-01A-01D-1434-08		19555888	135714672	202	377											
FAM120C	54954	broad.mit.edu	37	chrX	54209176	54209176	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taggcacaagcctggcacagCgctgacaagtagcccagcat	12	5	11	13	1	0	1	0	1	0	0	0	1	0	1	2	2	4	5	2	2	4	2			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chrX:54209176C>G	uc004dsz.3	-	1	539	c.456G>C	c.(454-456)GCG>GCC	p.A152A	FAM120C_uc011moh.1_Silent_p.A152A|FAM120C_uc004dta.2_Silent_p.A152A	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	152										ovary(1)|central_nervous_system(1)	2						CCTGGCACAGCGCTGACAAGT	0.697													3	15					0	0	0	0	G	54209176	G	G	54209176	2	3	2	1	0	0	0	0	0	0	0	1	5446	755	27	3		3	FAM120C	23	54209176	Silent	SNP	C	TCGA-BA-4075-01A-01D-1434-08	34653288	54209176	101061384	203	378											
DCAF12L2	340578	broad.mit.edu	37	chrX	125298829	125298830	+	Missense_Mutation	DNP	TG	AT	AT																															tgcccacagtgatgatgtgcTggtagaagctcagcgaccgc																										TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chrX:125298829_125298830TG>AT	uc004euk.1	-	1	1105_1106	c.1078_1079CA>AT	c.(1078-1080)CAG>ATG	p.Q360M		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	360	WD 4.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GATGATGTGCTGGTAGAAGCTC	0.639													12	85					0	0	0	0	AT	125298830	AT	AT	125298829	3	1	2	1	0	0	0	0	1	0	0	0	4282	1580	55	5	316	5	DCAF12L2	23	125298829	Missense_Mutation	DNP	TG	TCGA-BA-4075-01A-01D-1434-08	71089653	125298829	29971731	204	379											
ZNF75D	7626	broad.mit.edu	37	chrX	134427679	134427679	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	attctttgttccatcaggctCcctctgcaagaattccacca	9	13	5	14	0	3	1	1	0	2	1	6	1	6	1	4	1	1	3	4	1	2	4			TCGA-BA-4075-01A-01D-1434-08	TCGA-BA-4075-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5b3fec35-d127-4cb5-859b-edac003acdf3	5e8d7595-2397-40ce-8c2e-63b352605fe6	g.chrX:134427679C>G	uc004eyp.2	-	3	3043	c.388G>C	c.(388-390)GAG>CAG	p.E130Q	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'Flank|ZNF75D_uc004eyo.2_Missense_Mutation_p.E130Q	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	130	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCATCAGGCTCCCTCTGCAAG	0.453													56	34					0	0	0	0	G	134427679	G	G	134427679	3	3	2	1	0	0	0	0	1	0	0	0	18201	864	30	2	1164	2	ZNF75D	23	134427679	Missense_Mutation	SNP	C	TCGA-BA-4075-01A-01D-1434-08	9128850	134427679	20842881	205	380											
MEGF6	1953	broad.mit.edu	37	chr1	3512006	3512006	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgtagcccatgtagtagAcggttctagaaagaaagaga	14	8	12	7	1	1	4	0	0	1	4	1	5	1	4	2	1	1	4	2	1	6	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:3512006A>T	uc001akl.2	-	3	499	c.272T>A	c.(271-273)GTC>GAC	p.V91D		NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	91	EMI.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CATGTAGTAGACGGTTCTAGA	0.617													23	49					0	0	0	0	T	3512006	T	T	3512006	3	4	3	1	0	0	0	0	1	0	0	0	9515	275	10	5	4493	5	MEGF6	1	3512006	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08		3512006	245738615	1	381											
VPS13D	55187	broad.mit.edu	37	chr1	12557603	12557603	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttgctgcacggggccccagGggctgcttccccgatattct	4	10	13	14	2	1	0	0	0	1	0	2	1	2	0	4	4	3	5	4	4	1	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:12557603G>C	uc001atv.2	+	68	12853	c.12712G>C	c.(12712-12714)GGG>CGG	p.G4238R	VPS13D_uc001atw.2_Missense_Mutation_p.G4213R|VPS13D_uc001atx.2_Missense_Mutation_p.G3425R|VPS13D_uc009vnl.2_RNA|VPS13D_uc010obd.1_Missense_Mutation_p.G236R	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	4237					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GGGGCCCCAGGGGCTGCTTCC	0.517													42	84					0	0	0	0	C	12557603	C	C	12557603	3	2	3	1	0	0	0	0	1	0	0	0	17260	1232	43	4	12978	4	VPS13D	1	12557603	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	9045597	12557603	236693018	2	382											
CELA2A	63036	broad.mit.edu	37	chr1	15788127	15788127	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccctgatagccaacagctgGgtcctgacggctgcccactg	7	8	11	15	1	0	2	0	2	0	0	2	2	2	2	4	2	4	2	4	2	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:15788127G>T	uc001awk.2	+	3	227	c.201G>T	c.(199-201)TGG>TGT	p.W67C		NM_033440	NP_254275	P08217	CEL2A_HUMAN	elastase 2A preproprotein	67	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						CCAACAGCTGGGTCCTGACGG	0.607													51	100					4.25531e-23	5.32489e-23	1	0	T	15788127	T	T	15788127	3	4	3	1	0	0	0	0	1	0	0	0	3226	1241	43	4	211	4	CELA2A	1	15788127	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	3230524	15788127	233462494	3	383											
HSPG2	3339	broad.mit.edu	37	chr1	22168731	22168731	+	Splice_Site	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggcatctgccatactcaCggtaggaagacccctcactg	10	8	9	14	1	3	1	2	0	1	1	3	2	3	2	3	3	2	2	3	3	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:22168731C>A	uc001bfj.2	-	68	9092	c.9052_splice	c.e68+1	p.R3018_splice	HSPG2_uc009vqd.2_Splice_Site_p.R3019_splice	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor						angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GCCATACTCACGGTAGGAAGA	0.652													25	37					2.39556e-15	2.77287e-15	1	0	A	22168731	A	A	22168731	5	1	3	1	0	0	0	0	0	0	1	0	7469	550	19	3	4242	3	HSPG2	1	22168731	Splice_Site	SNP	C	TCGA-BA-4076-01A-01D-1434-08	6380604	22168731	227081890	4	384											
IQCC	55721	broad.mit.edu	37	chr1	32672224	32672224	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaggccacctgggaggagAtggtgctgaagaagtcagga	12	5	18	6	0	1	4	1	1	0	3	1	8	1	6	2	5	1	1	2	5	2	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:32672224A>C	uc001bum.2	+	3	348	c.301A>C	c.(301-303)ATG>CTG	p.M101L	IQCC_uc009vua.2_Missense_Mutation_p.M181L|IQCC_uc010ogz.1_Missense_Mutation_p.M1L|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	101										ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CTGGGAGGAGATGGTGCTGAA	0.547													56	77					0	0	0	0	C	32672224	C	C	32672224	3	2	3	1	0	0	0	0	1	0	0	0	7843	333	12	5	551	5	IQCC	1	32672224	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	10503493	32672224	216578397	5	385											
CSMD2	114784	broad.mit.edu	37	chr1	34180272	34180272	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgccctccagacggtacccGgggaagcaggagaaggtcaa	11	4	15	11	2	1	2	1	0	0	2	2	4	2	3	3	5	3	2	3	5	4	1	rs145807635		TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:34180272G>A	uc001bxn.1	-	21	3230	c.3201C>T	c.(3199-3201)CCC>CCT	p.P1067P	CSMD2_uc001bxm.1_Silent_p.P1107P	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1067	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GACGGTACCCGGGGAAGCAGG	0.662													96	122					0	0	0	0	A	34180272	A	A	34180272	2	1	3	1	0	0	0	0	0	0	0	1	3962	1103	39	1		1	CSMD2	1	34180272	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	1508048	34180272	215070349	6	386											
TIE1	7075	broad.mit.edu	37	chr1	43774729	43774729	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgatgccccggatcaactGtgcagctgcagggaacccct	9	6	12	14	2	1	0	1	0	0	0	1	4	1	2	4	2	6	3	4	2	2	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:43774729G>C	uc001ciu.2	+	8	1194	c.1115G>C	c.(1114-1116)TGT>TCT	p.C372S	TIE1_uc010okd.1_Missense_Mutation_p.C372S|TIE1_uc010oke.1_Missense_Mutation_p.C327S|TIE1_uc009vwq.2_Missense_Mutation_p.C328S|TIE1_uc010okf.1_Missense_Mutation_p.C17S|TIE1_uc010okg.1_Missense_Mutation_p.C17S|TIE1_uc010okc.1_Intron	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	372	Ig-like C2-type 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CGGATCAACTGTGCAGCTGCA	0.607													37	75					0	0	0	0	C	43774729	C	C	43774729	3	2	3	1	0	0	0	0	1	0	0	0	15959	1377	48	4	1145	4	TIE1	1	43774729	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	9594457	43774729	205475892	7	387											
EIF2B3	8891	broad.mit.edu	37	chr1	45407189	45407189	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttccttacctgctttttttTtccccttttgaccgggaaca	5	18	5	13	1	0	1	0	1	0	0	2	2	2	2	5	1	3	1	5	1	2	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:45407189T>G	uc001cmt.1	-	4	570	c.443A>C	c.(442-444)AAA>ACA	p.K148T	EIF2B3_uc001cmu.1_Missense_Mutation_p.K148T|EIF2B3_uc001cmv.1_Missense_Mutation_p.K148T|EIF2B3_uc001cmw.2_Missense_Mutation_p.K148T	NM_020365	NP_065098	Q9NR50	EI2BG_HUMAN	eukaryotic translation initiation factor 2B,	148					negative regulation of translational initiation in response to stress|oligodendrocyte development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	nucleotidyltransferase activity|protein binding|translation initiation factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGCTTTTTTTTTCCCCTTTTG	0.338													78	110					0	0	0	0	G	45407189	G	G	45407189	3	3	3	1	0	0	0	0	1	0	0	0	5024	1841	64	5	988	5	EIF2B3	1	45407189	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	1632460	45407189	203843432	8	388											
ZFYVE9	9372	broad.mit.edu	37	chr1	52705124	52705124	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctcagagctggtcagtttGgaatttctgccagaaagcca	11	11	10	9	0	3	2	2	0	2	2	4	3	3	3	2	2	3	2	2	2	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:52705124G>T	uc001cto.2	+	4	2207	c.2035G>T	c.(2035-2037)GGA>TGA	p.G679*	ZFYVE9_uc001ctn.2_Nonsense_Mutation_p.G679*|ZFYVE9_uc001ctp.2_Nonsense_Mutation_p.G679*	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	679					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						TGGTCAGTTTGGAATTTCTGC	0.478													78	123					1.13027e-35	1.57151e-35	1	0	T	52705124	T	T	52705124	4	4	3	1	0	0	0	0	0	1	0	0	17738	1349	47	4	2041	4	ZFYVE9	1	52705124	Nonsense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	7297935	52705124	196545497	9	389											
C1orf168	199920	broad.mit.edu	37	chr1	57258099	57258099	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagctattggccaccattacTttttccttagtgattatctc	9	17	5	10	0	1	1	0	1	1	0	3	1	2	1	3	1	2	1	3	1	5	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:57258099T>C	uc001cym.3	-	2	793	c.387A>G	c.(385-387)AAA>AAG	p.K129K	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Silent_p.K129K	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	129										ovary(3)|skin(2)	5						CCACCATTACTTTTTCCTTAG	0.418													116	176					0	0	0	0	C	57258099	C	C	57258099	2	2	3	1	0	0	0	0	0	0	0	1	2021	1606	56	5		5	C1orf168	1	57258099	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	4552975	57258099	191992522	10	390											
LRRIQ3	127255	broad.mit.edu	37	chr1	74507186	74507186	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaactgttctgaattgtctCtttattttcttcaattagtt	9	22	4	6	0	4	1	1	1	3	0	5	1	4	1	0	0	1	2	0	0	6	10			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:74507186C>A	uc001dfy.3	-	7	1621	c.1429G>T	c.(1429-1431)GAG>TAG	p.E477*	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	477										ovary(2)	2						TGAATTGTCTCTTTATTTTCT	0.338													84	136					7.63117e-38	1.06744e-37	1	0	A	74507186	A	A	74507186	4	1	3	1	0	0	0	0	0	1	0	0	9080	922	32	2	453	2	LRRIQ3	1	74507186	Nonsense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	17249087	74507186	174743435	11	391											
C1orf173	127254	broad.mit.edu	37	chr1	75078365	75078365	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtagcctcgtttgcctcCaagcctggaacctttccgat	9	11	8	13	2	0	0	0	0	0	0	3	2	2	1	6	1	4	2	6	1	4	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:75078365C>A	uc001dgg.2	-	9	1348	c.1129G>T	c.(1129-1131)GGA>TGA	p.G377*	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Nonsense_Mutation_p.G171*	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	377										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CGTTTGCCTCCAAGCCTGGAA	0.458													28	53					3.73148e-12	4.15306e-12	1	0	A	75078365	A	A	75078365	4	1	3	1	0	0	0	0	0	1	0	0	2023	603	21	4	3487	4	C1orf173	1	75078365	Nonsense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	571179	75078365	174172256	12	392											
ACADM	34	broad.mit.edu	37	chr1	76211507	76211507	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaggtattttttattggcaCgttctgatccagatcctaaa	10	17	7	7	1	1	2	0	1	1	1	3	2	3	2	2	2	0	3	2	2	5	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:76211507C>T	uc001dgw.3	+	8	1046	c.616C>T	c.(616-618)CGT>TGT	p.R206C	ACADM_uc010ord.1_Missense_Mutation_p.R120C|ACADM_uc009wbp.2_Missense_Mutation_p.R210C|ACADM_uc009wbr.2_Missense_Mutation_p.R239C|ACADM_uc010ore.1_Missense_Mutation_p.R170C|ACADM_uc010orf.1_Missense_Mutation_p.R17C|ACADM_uc001dgx.3_Missense_Mutation_p.R120C|ACADM_uc010org.1_Missense_Mutation_p.R76C|ACADM_uc009wbs.1_RNA	NM_000016	NP_000007	P11310	ACADM_HUMAN	medium-chain acyl-CoA dehydrogenase isoform a	206			R -> L (in ACADMD).		carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4						TTTATTGGCACGTTCTGATCC	0.353													43	81					0	0	0	0	T	76211507	T	T	76211507	3	4	3	1	0	0	0	0	1	0	0	0	113	536	19	1	658	1	ACADM	1	76211507	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1133142	76211507	173039114	13	393											
MSH4	4438	broad.mit.edu	37	chr1	76365379	76365379	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatcacaactcaaattacGagacaaattttggtaagaaa	20	9	6	6	1	2	2	2	0	0	2	2	4	2	2	0	1	2	1	0	1	7	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:76365379G>T	uc001dhd.1	+	19	2648	c.2607G>T	c.(2605-2607)ACG>ACT	p.T869T		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	869					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						CTCAAATTACGAGACAAATTT	0.279								MMR					49	57					2.43468e-25	3.10539e-25	1	0	T	76365379	T	T	76365379	2	4	3	1	0	0	0	0	0	0	0	1	9925	1045	37	3		3	MSH4	1	76365379	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	153872	76365379	172885242	14	394											
ST6GALNAC3	256435	broad.mit.edu	37	chr1	76877870	76877870	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgattcgagttgtgtcccatAccagcgttcctcttttgcta	6	16	8	11	2	1	1	0	1	1	0	4	2	3	1	3	0	3	3	3	0	2	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:76877870A>T	uc001dhh.2	+	3	554	c.391A>T	c.(391-393)ACC>TCC	p.T131S	ST6GALNAC3_uc001dhg.3_Missense_Mutation_p.T131S|ST6GALNAC3_uc010orh.1_Missense_Mutation_p.T66S	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	131	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						TGTGTCCCATACCAGCGTTCC	0.423													69	75					0	0	0	0	T	76877870	T	T	76877870	3	4	3	1	0	0	0	0	1	0	0	0	15291	391	14	5	401	5	ST6GALNAC3	1	76877870	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	512491	76877870	172372751	15	395											
DPYD	1806	broad.mit.edu	37	chr1	97658799	97658799	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctgattctgaatggcactGcatacctagaaaagacagag	14	9	9	9	0	1	5	0	2	1	3	2	5	2	5	2	1	2	2	2	1	5	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:97658799G>A	uc001drv.2	-	20	2585	c.2448C>T	c.(2446-2448)TGC>TGT	p.C816C		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	816					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GAATGGCACTGCATACCTAGA	0.358													14	26					0	0	0	0	A	97658799	A	A	97658799	2	1	3	1	0	0	0	0	0	0	0	1	4767	1311	46	4		4	DPYD	1	97658799	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	20780929	97658799	151591822	16	396											
VCAM1	7412	broad.mit.edu	37	chr1	101197026	101197026	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agttacatattgatgacatgGaattcgaacccaaacaaagg	17	9	8	7	1	0	2	0	2	0	0	1	4	0	3	1	2	3	1	1	2	6	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:101197026G>C	uc001dti.2	+	6	1597	c.1477G>C	c.(1477-1479)GAA>CAA	p.E493Q	VCAM1_uc001dtj.2_Missense_Mutation_p.E401Q|VCAM1_uc010ouj.1_Missense_Mutation_p.E431Q	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	493	Ig-like C2-type 5.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	TGATGACATGGAATTCGAACC	0.373													37	70					0	0	0	0	C	101197026	C	C	101197026	3	2	3	1	0	0	0	0	1	0	0	0	17205	1175	41	2	1499	2	VCAM1	1	101197026	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	3538227	101197026	148053595	17	397											
COL11A1	1301	broad.mit.edu	37	chr1	103431074	103431074	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccactccccctggcccaggaGggccggtcttgccttgaaat	6	8	11	16	1	1	1	0	1	1	0	2	2	2	2	6	4	1	0	6	4	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:103431074G>T	uc001dul.2	-	38	3203	c.2885C>A	c.(2884-2886)CCT>CAT	p.P962H	COL11A1_uc001duk.2_Missense_Mutation_p.P158H|COL11A1_uc001dum.2_Missense_Mutation_p.P974H|COL11A1_uc001dun.2_Missense_Mutation_p.P923H|COL11A1_uc009weh.2_Missense_Mutation_p.P846H	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	962	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGGCCCAGGAGGGCCGGTCTT	0.388													80	158					3.24273e-39	4.56348e-39	1	0	T	103431074	T	T	103431074	3	4	3	1	0	0	0	0	1	0	0	0	3682	1000	35	4	2655	4	COL11A1	1	103431074	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	2234048	103431074	145819547	18	398											
SYPL2	284612	broad.mit.edu	37	chr1	110022063	110022063	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtttgtgttcaaggagaccCcgtggcatggacagggccag	8	8	16	9	1	1	1	1	0	0	1	1	3	1	2	3	5	0	3	3	5	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:110022063C>A	uc001dxp.2	+	6	1078	c.712C>A	c.(712-714)CCG>ACG	p.P238T	SYPL2_uc010ovk.1_Missense_Mutation_p.P174T	NM_001040709	NP_001035799	Q5VXT5	SYPL2_HUMAN	mitsugumin 29	238	Cytoplasmic (Potential).|MARVEL.					integral to membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		CAAGGAGACCCCGTGGCATGG	0.408													37	85					9.45814e-24	1.18998e-23	1	0	A	110022063	A	A	110022063	3	1	3	1	0	0	0	0	1	0	0	0	15529	623	22	4	734	4	SYPL2	1	110022063	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	6590989	110022063	139228558	19	399											
ADORA3	140	broad.mit.edu	37	chr1	112028408	112028408	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttttggtcaaatgactgatTacagagatgattcccaaacc	13	12	7	9	0	1	4	1	3	0	1	2	5	2	4	2	1	2	0	2	1	3	4	rs145936359		TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:112028408T>G	uc001ebf.2	-	5	1694	c.927A>C	c.(925-927)GTA>GTC	p.V309V	ADORA3_uc001ebg.3_Silent_p.V228V	NM_020683	NP_065734	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 1	Error:Variant_position_missing_in_P33765_after_alignment					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	AATGACTGATTACAGAGATGA	0.433													57	68					0	0	0	0	G	112028408	G	G	112028408	2	3	3	1	0	0	0	0	0	0	0	1	329	1741	61	5		5	ADORA3	1	112028408	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	2006345	112028408	137222213	20	400											
NOTCH2NL	388677	broad.mit.edu	37	chr1	145273312	145273312	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacgtgccgatgtgcctcaGggtttacaggagaggactgc	8	8	14	11	2	1	1	1	0	0	1	1	4	1	2	3	3	4	1	3	3	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:145273312G>C	uc001emn.3	+	3	536	c.166G>C	c.(166-168)GGG>CGG	p.G56R	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Missense_Mutation_p.G56R|NOTCH2NL_uc001emo.2_Missense_Mutation_p.G56R|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	56	EGF-like 2.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						ATGTGCCTCAGGGTTTACAGG	0.567													55	414					0	0	0	0	C	145273312	C	C	145273312	3	2	3	1	0	0	0	0	1	0	0	0	10603	1000	35	4	172	4	NOTCH2NL	1	145273312	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	33244904	145273312	103977309	21	401											
PRUNE	58497	broad.mit.edu	37	chr1	151001309	151001309	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcagatctccatgctttctgCcaggctcacagctatgatgt	8	12	9	12	0	3	2	1	1	2	1	4	2	3	2	2	1	3	4	2	1	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:151001309C>T	uc001ewh.1	+	7	958	c.822C>T	c.(820-822)TGC>TGT	p.C274C	PRUNE_uc001ewi.1_Silent_p.C92C|PRUNE_uc010pco.1_Silent_p.C42C|PRUNE_uc001ewj.1_Intron|PRUNE_uc001ewk.1_Intron	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	274						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ATGCTTTCTGCCAGGCTCACA	0.483													4	167					0	0	0	0	T	151001309	T	T	151001309	2	4	3	1	0	0	0	0	0	0	0	1	12702	747	26	4		4	PRUNE	1	151001309	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5727997	151001309	98249312	22	402											
IVL	3713	broad.mit.edu	37	chr1	152883976	152883976	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagggagaagtattgcttcCtgtagagcaccagcagcaga	14	7	12	8	0	0	3	0	0	0	3	1	4	1	3	2	1	4	6	2	1	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:152883976C>A	uc001fau.2	+	2	1749	c.1703C>A	c.(1702-1704)CCT>CAT	p.P568H		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	568					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTATTGCTTCCTGTAGAGCAC	0.488													65	87					4.66136e-34	6.38524e-34	1	0	A	152883976	A	A	152883976	3	1	3	1	0	0	0	0	1	0	0	0	7968	681	24	4	1705	4	IVL	1	152883976	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1882667	152883976	96366645	23	403											
DCAF8	50717	broad.mit.edu	37	chr1	160249948	160249948	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgcctcaaactgctcacatAttttgcacatgacgctgtgc	9	12	7	13	1	2	1	2	1	0	0	2	1	2	1	1	0	5	3	1	0	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:160249948A>G	uc010pjc.1	-	4	514	c.242T>C	c.(241-243)ATA>ACA	p.I81T	PEX19_uc010pje.1_RNA|PEX19_uc001fvs.2_Missense_Mutation_p.I228T|PEX19_uc001fvt.2_Missense_Mutation_p.I138T	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	Error:Variant_position_missing_in_Q5TAQ9_after_alignment						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						CTGCTCACATATTTTGCACAT	0.468													137	208					0	0	0	0	G	160249948	G	G	160249948	3	3	3	1	0	0	0	0	1	0	0	0	4293	449	16	5		5	DCAF8	1	160249948	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	7365972	160249948	89000673	24	404											
LMX1A	4009	broad.mit.edu	37	chr1	165218667	165218667	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtctgaggctgctgggctCaccaggctgagcagctcccg	6	7	15	13	1	2	2	1	2	1	0	3	3	3	2	2	3	3	6	2	3	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:165218667C>T	uc001gcy.1	-	3	695	c.474G>A	c.(472-474)GTG>GTA	p.V158V	LMX1A_uc001gcz.1_Silent_p.V158V	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	158						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CTGCTGGGCTCACCAGGCTGA	0.612													21	67					0	0	0	0	T	165218667	T	T	165218667	2	4	3	1	0	0	0	0	0	0	0	1	8903	813	29	2		2	LMX1A	1	165218667	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	4968719	165218667	84031954	25	405											
F5	2153	broad.mit.edu	37	chr1	169510646	169510646	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctggagaaatgggcatctGaccgagggctggggaaaggt	10	7	18	6	1	2	2	0	1	2	1	2	5	2	3	1	6	0	2	1	6	2	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:169510646G>A	uc001ggg.1	-	13	3827	c.3682C>T	c.(3682-3684)CAG>TAG	p.Q1228*		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1228	2-5.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ATGGGCATCTGACCGAGGGCT	0.527													177	243					0	0	0	0	A	169510646	A	A	169510646	4	1	3	1	0	0	0	0	0	1	0	0	5373	1299	45	2	3044	2	F5	1	169510646	Nonsense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	4291979	169510646	79739975	26	406											
SELL	6402	broad.mit.edu	37	chr1	169672410	169672410	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcactttgacatattggaCtaggatttgaccagattcca	12	13	7	9	0	1	3	1	2	0	1	2	5	2	5	2	2	0	0	2	2	2	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:169672410C>G	uc001ggk.2	-	6	1136	c.938G>C	c.(937-939)AGT>ACT	p.S313T	C1orf112_uc001ggj.2_Intron|SELL_uc010pls.1_Missense_Mutation_p.S266T|SELL_uc001ggl.1_Missense_Mutation_p.S326T	NM_000655	NP_000646	P14151	LYAM1_HUMAN	selectin L precursor	313	Extracellular (Potential).|Sushi 2.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding				0	all_hematologic(923;0.208)					ACATATTGGACTAGGATTTGA	0.383													12	20					0	0	0	0	G	169672410	G	G	169672410	3	3	3	1	0	0	0	0	1	0	0	0	14081	565	20	4	196	4	SELL	1	169672410	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	161764	169672410	79578211	27	407											
ANKRD45	339416	broad.mit.edu	37	chr1	173579330	173579330	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttctggtcatggcttgttAcagatttggcacttttcact	6	18	8	9	0	4	1	2	0	2	1	4	1	4	1	0	3	1	3	0	3	1	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:173579330A>G	uc001gja.1	-	6	816	c.755T>C	c.(754-756)GTA>GCA	p.V252A		NM_198493	NP_940895	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	268											0						ATGGCTTGTTACAGATTTGGC	0.338													54	113					0	0	0	0	G	173579330	G	G	173579330	3	3	3	1	0	0	0	0	1	0	0	0	673	391	14	5	49	5	ANKRD45	1	173579330	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	3906920	173579330	75671291	28	408											
NPHS2	7827	broad.mit.edu	37	chr1	179533895	179533895	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaaatgaggacaagaagcCactcacaggcccctaagccg	14	3	12	12	1	1	2	1	1	0	1	1	4	1	4	4	3	2	0	4	3	4	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:179533895C>A	uc001gmq.3	-	2	393	c.308G>T	c.(307-309)TGG>TTG	p.W103L	NPHS2_uc009wxi.2_Missense_Mutation_p.W103L	NM_014625	NP_055440	Q9NP85	PODO_HUMAN	podocin	103					excretion	integral to plasma membrane	protein binding				0						GACAAGAAGCCACTCACAGGC	0.403													28	40					8.24728e-16	9.5942e-16	1	0	A	179533895	A	A	179533895	3	1	3	1	0	0	0	0	1	0	0	0	10637	595	21	4	871	4	NPHS2	1	179533895	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5954565	179533895	69716726	29	409											
RGS21	431704	broad.mit.edu	37	chr1	192321323	192321323	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatttattctgaattcattGaagctgatgcacctaaagag	13	14	8	6	0	2	5	1	4	1	1	2	5	2	5	1	0	2	2	1	0	5	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:192321323G>T	uc001gsh.2	+	4	409	c.235G>T	c.(235-237)GAA>TAA	p.E79*		NM_001039152	NP_001034241	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	79	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2						TGAATTCATTGAAGCTGATGC	0.383													14	34					2.32078e-09	2.51057e-09	1	0	T	192321323	T	T	192321323	4	4	3	1	0	0	0	0	0	1	0	0	13369	1291	45	2	245	2	RGS21	1	192321323	Nonsense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	12787428	192321323	56929298	30	410											
CFHR5	81494	broad.mit.edu	37	chr1	196965026	196965026	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggacaactttacccacttgtGttggtaaataaatattaaca	15	13	6	7	0	0	0	0	0	0	0	0	1	0	1	1	2	3	2	1	2	8	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:196965026G>A	uc001gts.3	+	5	915	c.787G>A	c.(787-789)GTT>ATT	p.V263I		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	263	Sushi 4.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						ACCCACTTGTGTTGGTAAATA	0.289													28	35					0	0	0	0	A	196965026	A	A	196965026	3	1	3	1	0	0	0	0	1	0	0	0	3303	1377	48	4	805	4	CFHR5	1	196965026	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	4643703	196965026	52285595	31	411											
PFKFB2	5208	broad.mit.edu	37	chr1	207235301	207235301	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtttcatttccttctagcatGggcctcctacatgaccaact	8	14	6	13	0	2	1	1	1	1	0	4	1	4	1	4	1	3	2	4	1	3	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:207235301G>T	uc001hfg.2	+	3	198	c.89G>T	c.(88-90)TGG>TTG	p.W30L	PFKFB2_uc010psc.1_5'UTR|PFKFB2_uc001hfh.2_Missense_Mutation_p.W30L|PFKFB2_uc009xcc.2_5'UTR	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	30	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					CTTCTAGCATGGGCCTCCTAC	0.353													54	107					5.10652e-33	6.91322e-33	1	0	T	207235301	T	T	207235301	3	4	3	1	0	0	0	0	1	0	0	0	11816	1357	47	4	95	4	PFKFB2	1	207235301	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	10270275	207235301	42015320	32	412											
USH2A	7399	broad.mit.edu	37	chr1	215931940	215931940	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcttttttttttttacctgGtggtatccaagctacaaata	9	20	5	7	0	1	0	0	0	1	0	2	0	2	0	2	2	3	2	2	2	6	10			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:215931940G>C	uc001hku.1	-	58	11773	c.11386C>G	c.(11386-11388)CCA>GCA	p.P3796A		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3796	Fibronectin type-III 23.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTTTTACCTGGTGGTATCCAA	0.299										HNSCC(13;0.011)			60	92					0	0	0	0	C	215931940	C	C	215931940	3	2	3	1	0	0	0	0	1	0	0	0	17104	1261	44	4	4282	4	USH2A	1	215931940	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	8696639	215931940	33318681	33	413											
USH2A	7399	broad.mit.edu	37	chr1	216373451	216373451	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaacaggtctgtgtctaagAagtattgaatacctgaaatg	14	12	10	5	0	2	3	0	2	2	1	2	3	2	3	1	1	2	2	1	1	7	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:216373451A>G	uc001hku.1	-	17	3716	c.3329T>C	c.(3328-3330)TTC>TCC	p.F1110S	USH2A_uc001hkv.2_Missense_Mutation_p.F1110S	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1110	Extracellular (Potential).|Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTGTCTAAGAAGTATTGAAT	0.328										HNSCC(13;0.011)			29	46					0	0	0	0	G	216373451	G	G	216373451	3	3	3	1	0	0	0	0	1	0	0	0	17104	246	9	5	12517	5	USH2A	1	216373451	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	441511	216373451	32877170	34	414											
LEFTY2	7044	broad.mit.edu	37	chr1	226127684	226127684	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgctggcctccgacgccAggaacctgccggccacctct	5	7	12	17	3	1	0	0	0	1	0	2	2	2	1	7	3	3	1	7	3	1	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:226127684A>T	uc001hpt.1	-	2	349	c.269T>A	c.(268-270)CTG>CAG	p.L90Q	LEFTY2_uc010pvk.1_Missense_Mutation_p.L90Q|LEFTY2_uc009xek.1_Intron	NM_003240	NP_003231	O00292	LFTY2_HUMAN	endometrial bleeding associated factor	90					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					CTCCGACGCCAGGAACCTGCC	0.697													9	18					0	0	0	0	T	226127684	T	T	226127684	3	4	3	1	0	0	0	0	1	0	0	0	8756	188	7	5	843	5	LEFTY2	1	226127684	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	9754233	226127684	23122937	35	415											
PGBD5	79605	broad.mit.edu	37	chr1	230472906	230472906	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgatgctgggccccgtGaaaatgatgtagttcttgcc	7	12	13	9	1	1	3	0	3	1	0	1	3	1	3	3	2	2	3	3	2	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:230472906G>T	uc010pwb.1	-	4	816	c.816C>A	c.(814-816)TTC>TTA	p.F272L	PGBD5_uc001htv.2_Missense_Mutation_p.F371L	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	272						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		TGGGCCCCGTGAAAATGATGT	0.597													43	64					4.44401e-20	5.40047e-20	1	0	T	230472906	T	T	230472906	3	4	3	1	0	0	0	0	1	0	0	0	11839	1281	45	2	567	2	PGBD5	1	230472906	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	4345222	230472906	18777715	36	416											
TBCE	6905	broad.mit.edu	37	chr1	235600733	235600733	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggacaaagaagcagagacgGcgcgactactcattatcgcc	14	5	11	11	4	1	2	1	0	0	2	2	5	1	3	1	2	2	1	1	2	4	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:235600733G>T	uc001hwz.1	+	12	1183	c.1060G>T	c.(1060-1062)GCG>TCG	p.A354S	TBCE_uc010pxq.1_RNA|TBCE_uc001hxa.1_Missense_Mutation_p.A354S|TBCE_uc010pxr.1_Missense_Mutation_p.A405S|TBCE_uc001hxb.1_Missense_Mutation_p.A241S	NM_003193	NP_003184	Q15813	TBCE_HUMAN	beta-tubulin cofactor E	354	LRRCT.				'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			AGCAGAGACGGCGCGACTACT	0.468													52	67					1.86277e-20	2.26964e-20	1	0	T	235600733	T	T	235600733	3	4	3	1	0	0	0	0	1	0	0	0	15700	1203	42	4	1102	4	TBCE	1	235600733	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	5127827	235600733	13649888	37	417											
RYR2	6262	broad.mit.edu	37	chr1	237947941	237947941	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggctttttccgcatcatttGcagcctgctgcttgggggaa	6	13	12	10	1	1	0	1	0	0	0	2	1	2	1	2	3	4	5	2	3	1	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:237947941G>A	uc001hyl.1	+	90	13049	c.12929G>A	c.(12928-12930)TGC>TAC	p.C4310Y	RYR2_uc010pya.1_Missense_Mutation_p.C725Y	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4310	Helical; Name=M4; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGCATCATTTGCAGCCTGCTG	0.498													28	53					0	0	0	0	A	237947941	A	A	237947941	3	1	3	1	0	0	0	0	1	0	0	0	13834	1319	46	4	13287	4	RYR2	1	237947941	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	2347208	237947941	11302680	38	418											
PLD5	200150	broad.mit.edu	37	chr1	242451748	242451748	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggccatgttgagtaaattCatccagccttggaaaagtga	12	12	10	7	0	1	2	1	2	0	0	2	3	2	3	3	2	1	2	3	2	4	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:242451748C>A	uc001hzn.1	-	3	538	c.411G>T	c.(409-411)ATG>ATT	p.M137I	PLD5_uc001hzl.3_Missense_Mutation_p.M75I|PLD5_uc001hzm.3_Intron|PLD5_uc001hzo.1_Missense_Mutation_p.M45I			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	137						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TGAGTAAATTCATCCAGCCTT	0.403													37	57					7.61001e-30	1.00383e-29	1	0	A	242451748	A	A	242451748	3	1	3	1	0	0	0	0	1	0	0	0	12104	826	29	2	1231	2	PLD5	1	242451748	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	4503807	242451748	6798873	39	419											
OR2W5	441932	broad.mit.edu	37	chr1	247655010	247655010	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcttgtgaggaaaccatgcTggtagaagcgattcaccttt	10	12	11	8	1	2	2	1	1	1	1	2	4	2	3	2	2	3	2	2	2	3	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:247655010T>C	uc001icz.1	+	1	581	c.581T>C	c.(580-582)CTG>CCG	p.L194P		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GAAACCATGCTGGTAGAAGCG	0.592													98	134					0	0	0	0	C	247655010	C	C	247655010	3	2	3	1	0	0	0	0	1	0	0	0	11088	1580	55	5	583	5	OR2W5	1	247655010	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	5203262	247655010	1595611	40	420											
OR2T33	391195	broad.mit.edu	37	chr1	248436753	248436753	+	Missense_Mutation	SNP	C	T	T																															gagtgggtggcagacagccgCatagcggtcataggccatgg																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:248436753C>T	uc010pzi.1	-	1	364	c.364G>A	c.(364-366)GCG>ACG	p.A122T		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CAGACAGCCGCATAGCGGTCA	0.612													16	62					0	0	0	0	T	248436753	T	T	248436753	3	4	3	1	0	0	0	0	1	0	0	0	11078	710	25	4	601	4	OR2T33	1	248436753	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	781743	248436753	813868	41	421	1	2									
OR2T33	391195	broad.mit.edu	37	chr1	248436759	248436759	+	Missense_Mutation	SNP	G	T	T																															gtggcagacagccgcatagcGgtcataggccatggctgcta																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:248436759G>T	uc010pzi.1	-	1	358	c.358C>A	c.(358-360)CGC>AGC	p.R120S		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCCGCATAGCGGTCATAGGCC	0.592													18	60					6.33695e-27	8.24159e-27	1	0	T	248436759	T	T	248436759	3	4	3	1	0	0	0	0	1	0	0	0	11078	1116	39	3	607	3	OR2T33	1	248436759	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	6	248436759	813862	42	422	1	2									
OR2M7	391196	broad.mit.edu	37	chr1	248487331	248487331	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggattagtagggaagggaaGtcacagcagaagtgggctat	14	7	16	4	0	1	1	1	0	0	1	1	4	1	4	0	4	1	3	0	4	6	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:248487331G>T	uc010pzk.1	-	1	540	c.540C>A	c.(538-540)GAC>GAA	p.D180E		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGGAAGGGAAGTCACAGCAGA	0.438													97	230					1.00589e-60	1.50235e-60	1	0	T	248487331	T	T	248487331	3	4	3	1	0	0	0	0	1	0	0	0	11068	1020	36	4	401	4	OR2M7	1	248487331	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	50572	248487331	763290	43	423											
OR2T6	254879	broad.mit.edu	37	chr1	248551581	248551581	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaccaggattctcatcacAgtgcatcagatgacatcggc	12	9	8	12	1	3	2	3	1	1	1	5	3	3	3	1	2	2	1	1	2	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr1:248551581A>T	uc001iei.1	+	1	672	c.672A>T	c.(670-672)ACA>ACT	p.T224T		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	224	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCTCATCACAGTGCATCAGA	0.498													75	63					0	0	0	0	T	248551581	T	T	248551581	2	4	3	1	0	0	0	0	0	0	0	1	11083	175	7	5		5	OR2T6	1	248551581	Silent	SNP	A	TCGA-BA-4076-01A-01D-1434-08	64250	248551581	699040	44	424											
NTSR2	23620	broad.mit.edu	37	chr2	11802111	11802111	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actgagaacctggacgctgcGctggaggctgcggatccggc	7	6	16	12	4	0	1	0	1	0	1	1	5	1	4	2	5	3	3	2	5	1	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:11802111G>A	uc002rbq.3	-	2	954	c.880C>T	c.(880-882)CGC>TGC	p.R294C		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	294	Cytoplasmic (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	TGGACGCTGCGCTGGAGGCTG	0.428													82	123					0	0	0	0	A	11802111	A	A	11802111	3	1	3	1	0	0	0	0	1	0	0	0	10765	1087	38	1	364	1	NTSR2	2	11802111	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08		11802111	231397262	45	425											
DPYSL5	56896	broad.mit.edu	37	chr2	27169818	27169819	+	Silent	DNP	TC	CA	CA																															gttccaaagcgagcttcagcTcggatcctcgctcctcccgg																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:27169818_27169819TC>CA	uc002rhu.3	+	13	1808_1809	c.1650_1651TC>CA	c.(1648-1653)GCTCGG>GCCAGG	p.550_551AR>AR	DPYSL5_uc002rhv.3_Silent_p.550_551AR>AR	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	550_551					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGCTTCAGCTCGGATCCTCGC	0.604													5	36					0	0	0	0	CA	27169819	CA	CA	27169818	2	2	3	1	0	0	0	0	0	0	0	1	4772	1538	54	5		5	DPYSL5	2	27169818	Silent	DNP	TC	TCGA-BA-4076-01A-01D-1434-08	15367707	27169818	216029555	46	426											
GALNT14	79623	broad.mit.edu	37	chr2	31167748	31167748	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggctccgtggggtccaggCgccgagccttctgctctggg	2	9	17	13	3	2	0	0	0	2	0	4	1	4	0	4	5	2	2	4	5	0	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:31167748C>A	uc002rnr.2	-	8	1422	c.803G>T	c.(802-804)CGC>CTC	p.R268L	GALNT14_uc002rnq.2_Missense_Mutation_p.R248L|GALNT14_uc002rns.2_Missense_Mutation_p.R273L|GALNT14_uc010ymr.1_Missense_Mutation_p.R233L|GALNT14_uc010ezo.1_Missense_Mutation_p.R235L|GALNT14_uc010ezp.1_Intron	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	268	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GGGGTCCAGGCGCCGAGCCTT	0.587													51	80					4.96213e-28	6.50841e-28	1	0	A	31167748	A	A	31167748	3	1	3	1	0	0	0	0	1	0	0	0	6247	768	27	3	887	3	GALNT14	2	31167748	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	3997930	31167748	212031625	47	427											
THADA	63892	broad.mit.edu	37	chr2	43801749	43801751	+	In_Frame_Del	DEL	CAT	-	-																															ggtaccaatgactggtctccCatcacctctaagatttgaga																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:43801749_43801751delCAT	uc002rsw.3	-	11	1805_1807	c.1453_1455delATG	c.(1453-1455)ATGdel	p.M485del	THADA_uc002rsx.3_In_Frame_Del_p.M485del|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_In_Frame_Del_p.M195del|THADA_uc002rta.2_In_Frame_Del_p.M195del|THADA_uc002rtb.1_In_Frame_Del_p.M485del|THADA_uc002rtc.3_In_Frame_Del_p.M485del|THADA_uc002rtd.2_In_Frame_Del_p.M485del	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	485							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				ACTGGTCTCCCATCACCTCTAAG	0.394													---	---	---								-	43801751	-	-	43801749	7	5	3	1	0	1	0	1	0	0	0	0	15906	594	21	0	4518	0	THADA	2	43801749	In_Frame_Del	DEL	CAT	TCGA-BA-4076-01A-01D-1434-08	12634001	43801749	199397624	48	428											
FAM161A	84140	broad.mit.edu	37	chr2	62081004	62081004	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtattaccgatgccccaGcgggctgagccactttctcc	7	9	9	16	2	1	1	0	1	1	0	2	2	1	1	6	1	4	2	6	1	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:62081004G>T	uc010ypo.1	-	1	275	c.173C>A	c.(172-174)GCT>GAT	p.A58D	FAM161A_uc002sbm.3_Missense_Mutation_p.A58D|FAM161A_uc002sbn.3_Translation_Start_Site|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Translation_Start_Site	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	58					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						CGATGCCCCAGCGGGCTGAGC	0.682													22	34					7.3207e-31	9.76796e-31	1	0	T	62081004	T	T	62081004	3	4	3	1	0	0	0	0	1	0	0	0	5500	971	34	4	1833	4	FAM161A	2	62081004	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	18279255	62081004	181118369	49	429											
CYP26B1	56603	broad.mit.edu	37	chr2	72361927	72361927	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatctccttcccgtgctccTtgctgctctcaatgaggagg	5	13	9	14	1	3	1	2	1	2	0	7	2	5	2	3	2	3	3	3	2	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:72361927T>A	uc002sih.1	-	4	824	c.824A>T	c.(823-825)AAG>ATG	p.K275M	CYP26B1_uc010yra.1_Missense_Mutation_p.K258M|CYP26B1_uc010yrb.1_Missense_Mutation_p.K200M	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	275					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2						CCCGTGCTCCTTGCTGCTCTC	0.622													19	43					0	0	0	0	A	72361927	A	A	72361927	3	1	3	1	0	0	0	0	1	0	0	0	4173	1609	56	5	726	5	CYP26B1	2	72361927	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	10280923	72361927	170837446	50	430											
LOXL3	84695	broad.mit.edu	37	chr2	74763560	74763560	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaggacttctacccggccCtctccagggtgggcgccgcc	4	8	12	17	3	3	0	1	0	2	0	4	1	3	1	5	4	1	0	5	4	1	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:74763560C>A	uc002smp.1	-	6	1023	c.951G>T	c.(949-951)GAG>GAT	p.E317D	LOXL3_uc002smo.1_Translation_Start_Site|LOXL3_uc010ffm.1_Missense_Mutation_p.E317D|LOXL3_uc002smq.1_Missense_Mutation_p.E172D|LOXL3_uc010ffn.1_Missense_Mutation_p.E172D	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	317	SRCR 3.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						CTACCCGGCCCTCTCCAGGGT	0.622													33	41					1.08312e-15	1.25685e-15	1	0	A	74763560	A	A	74763560	3	1	3	1	0	0	0	0	1	0	0	0	8951	680	24	4	1346	4	LOXL3	2	74763560	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2401633	74763560	168435813	51	431											
LRRTM4	80059	broad.mit.edu	37	chr2	77745800	77745800	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaagggcttggtgtttcaaAggtggattgggtgacgtcag	8	11	18	4	1	2	1	2	1	0	0	2	3	2	3	0	6	0	2	0	6	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:77745800A>G	uc002snr.2	-	3	1610	c.1195T>C	c.(1195-1197)TTT>CTT	p.F399L	LRRTM4_uc002snq.2_Missense_Mutation_p.F399L|LRRTM4_uc002sns.2_Missense_Mutation_p.F399L|LRRTM4_uc002snt.2_Missense_Mutation_p.F400L	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	399	Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GGTGTTTCAAAGGTGGATTGG	0.493													37	70					0	0	0	0	G	77745800	G	G	77745800	3	3	3	1	0	0	0	0	1	0	0	0	9092	72	3	5	591	5	LRRTM4	2	77745800	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	2982240	77745800	165453573	52	432											
LRRTM1	347730	broad.mit.edu	37	chr2	80530391	80530391	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtcgagaaacttgaggctgCggcagtcctggaagatgcgc	9	8	15	9	3	0	3	0	1	0	2	2	5	1	4	1	3	3	2	1	3	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:80530391C>A	uc002sok.1	-	2	824	c.554G>T	c.(553-555)CGC>CTC	p.R185L	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	185	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CTTGAGGCTGCGGCAGTCCTG	0.607										HNSCC(69;0.2)			41	44					3.05275e-18	3.63348e-18	1	0	A	80530391	A	A	80530391	3	1	3	1	0	0	0	0	1	0	0	0	9089	768	27	3	1018	3	LRRTM1	2	80530391	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2784591	80530391	162668982	53	433											
LRRTM1	347730	broad.mit.edu	37	chr2	80530685	80530685	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccacgtgagctgcattaacCccgtgaactggccggcgcgc	7	6	13	15	5	0	2	0	2	0	0	0	2	0	2	4	2	4	2	4	2	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:80530685C>A	uc002sok.1	-	2	530	c.260G>T	c.(259-261)GGG>GTG	p.G87V	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	87	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CTGCATTAACCCCGTGAACTG	0.622										HNSCC(69;0.2)			66	112					9.07738e-34	1.23977e-33	1	0	A	80530685	A	A	80530685	3	1	3	1	0	0	0	0	1	0	0	0	9089	623	22	4	1312	4	LRRTM1	2	80530685	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	294	80530685	162668688	54	434											
SLC35F5	80255	broad.mit.edu	37	chr2	114492205	114492205	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tagaaagggtaaatctatctCcactgttacttggaaatact	14	13	7	7	0	2	1	0	0	2	1	3	2	2	2	1	2	2	2	1	2	8	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:114492205C>A	uc002tku.1	-	9	1302	c.878G>T	c.(877-879)GGA>GTA	p.G293V	SLC35F5_uc002tkt.2_RNA	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	293	DUF6.				transport	integral to membrane					0						AAATCTATCTCCACTGTTACT	0.303													51	43					3.28156e-27	4.29198e-27	1	0	A	114492205	A	A	114492205	3	1	3	1	0	0	0	0	1	0	0	0	14656	855	30	2	721	2	SLC35F5	2	114492205	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	33961520	114492205	128707168	55	435											
DPP10	57628	broad.mit.edu	37	chr2	116510867	116510867	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagaccactacaggtgcttgTagtaaagtgagtataattta	14	12	10	5	0	0	2	0	1	0	1	0	3	0	2	1	1	2	4	1	1	7	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:116510867T>C	uc002tla.1	+	11	1525	c.1068T>C	c.(1066-1068)TGT>TGC	p.C356C	DPP10_uc002tlb.1_Silent_p.C306C|DPP10_uc002tlc.1_Silent_p.C352C|DPP10_uc002tle.2_Silent_p.C360C|DPP10_uc002tlf.1_Silent_p.C349C	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	356	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CAGGTGCTTGTAGTAAAGTGA	0.368													29	66					0	0	0	0	C	116510867	C	C	116510867	2	2	3	1	0	0	0	0	0	0	0	1	4749	1644	57	5		5	DPP10	2	116510867	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	2018662	116510867	126688506	56	436											
CNTNAP5	129684	broad.mit.edu	37	chr2	125192236	125192236	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaccttggaactccagaaGgggaggctcgccctacacct	10	7	10	14	1	1	1	1	0	0	1	3	3	2	3	4	4	2	1	4	4	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:125192236G>T	uc002tno.2	+	5	1069	c.705G>T	c.(703-705)AAG>AAT	p.K235N	CNTNAP5_uc010flu.2_Missense_Mutation_p.K235N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	235	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AACTCCAGAAGGGGAGGCTCG	0.532													16	36					6.49762e-13	7.3197e-13	1	0	T	125192236	T	T	125192236	3	4	3	1	0	0	0	0	1	0	0	0	3665	991	35	4	723	4	CNTNAP5	2	125192236	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	8681369	125192236	118007137	57	437											
CNTNAP5	129684	broad.mit.edu	37	chr2	125284872	125284872	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcccacagggtgccccgaCaatctcaccgattcccaatg	9	8	8	16	2	1	0	1	0	1	0	4	2	3	0	5	1	1	0	5	1	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:125284872C>A	uc002tno.2	+	10	1849	c.1485C>A	c.(1483-1485)GAC>GAA	p.D495E	CNTNAP5_uc010flu.2_Missense_Mutation_p.D496E	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	495	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGTGCCCCGACAATCTCACCG	0.448													23	75					0.000229342	0.000237021	1	0	A	125284872	A	A	125284872	3	1	3	1	0	0	0	0	1	0	0	0	3665	477	17	4	1523	4	CNTNAP5	2	125284872	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	92636	125284872	117914501	58	438											
CYP27C1	339761	broad.mit.edu	37	chr2	127950815	127950815	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctcaggccggaactccttgGcccgagggaagttctcatcc	7	8	12	14	2	2	0	2	0	1	0	5	3	4	2	4	4	1	2	4	4	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:127950815G>T	uc002tod.2	-	7	988	c.857C>A	c.(856-858)GCC>GAC	p.A286D		NM_001001665	NP_001001665	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C,	286						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		GAACTCCTTGGCCCGAGGGAA	0.537													81	77					1.39294e-53	2.06048e-53	1	0	T	127950815	T	T	127950815	3	4	3	1	0	0	0	0	1	0	0	0	4177	1203	42	4	269	4	CYP27C1	2	127950815	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	2665943	127950815	115248558	59	439											
LCT	3938	broad.mit.edu	37	chr2	136564931	136564931	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccatcagagaccaggcgaCataccctcgaaggtctatac	12	7	9	13	2	2	1	1	0	1	1	4	4	3	1	3	2	2	0	3	2	4	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:136564931C>T	uc002tuu.1	-	9	3951	c.3940G>A	c.(3940-3942)GTC>ATC	p.V1314I		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1314	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GACCAGGCGACATACCCTCGA	0.527													49	23					0	0	0	0	T	136564931	T	T	136564931	3	4	3	1	0	0	0	0	1	0	0	0	8733	478	17	4	1879	4	LCT	2	136564931	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	8614116	136564931	106634442	60	440											
LRP1B	53353	broad.mit.edu	37	chr2	141777503	141777503	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcatacccattaactggaTccaccacaattcctctggga	11	11	6	13	0	1	0	0	0	1	0	3	2	3	2	4	2	3	1	4	2	3	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:141777503T>C	uc002tvj.1	-	12	2930	c.1958A>G	c.(1957-1959)GAT>GGT	p.D653G	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	653	Extracellular (Potential).|LDL-receptor class B 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTAACTGGATCCACCACAAT	0.333										TSP Lung(27;0.18)			49	17					0	0	0	0	C	141777503	C	C	141777503	3	2	3	1	0	0	0	0	1	0	0	0	9005	1435	50	5	12161	5	LRP1B	2	141777503	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	5212572	141777503	101421870	61	441											
PSMD14	10213	broad.mit.edu	37	chr2	162247657	162247657	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacattattactccattactAttaactatcggaaaaatgaa	17	13	4	7	1	0	1	0	1	0	0	2	3	1	2	1	1	3	0	1	1	9	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:162247657A>G	uc002ubu.2	+	9	1080	c.613A>G	c.(613-615)ATT>GTT	p.I205V		NM_005805	NP_005796	O00487	PSDE_HUMAN	proteasome 26S subunit, non-ATPase 14	205					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K63-linked deubiquitination|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	endopeptidase activator activity|metal ion binding|metallopeptidase activity|proteasome binding|ubiquitin thiolesterase activity			breast(1)	1						CTCCATTACTATTAACTATCG	0.249													3	2					0	0	0	0	G	162247657	G	G	162247657	3	3	3	1	0	0	0	0	1	0	0	0	12759	449	16	5	639	5	PSMD14	2	162247657	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	20470154	162247657	80951716	62	442											
IFIH1	64135	broad.mit.edu	37	chr2	163133239	163133239	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgctgtgtccagctccaatCagatggtgggctttgactcc	6	12	11	12	0	1	2	1	1	0	1	4	2	4	2	3	2	2	3	3	2	1	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:163133239C>G	uc002uce.2	-	11	2484	c.2262G>C	c.(2260-2262)CTG>CTC	p.L754L		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	754	Helicase C-terminal.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						CAGCTCCAATCAGATGGTGGG	0.338													88	39					0	0	0	0	G	163133239	G	G	163133239	2	3	3	1	0	0	0	0	0	0	0	1	7559	813	29	2		2	IFIH1	2	163133239	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	885582	163133239	80066134	63	443											
FIGN	55137	broad.mit.edu	37	chr2	164467857	164467857	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacaggtactacttgaataaCtaggttctgtcaggttgctg	10	13	10	8	0	2	1	1	1	1	0	2	1	2	1	0	3	4	4	0	3	5	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:164467857C>A	uc002uck.1	-	3	796	c.485G>T	c.(484-486)AGT>ATT	p.S162I		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	162						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						ACTTGAATAACTAGGTTCTGT	0.517													41	20					2.24893e-16	2.63609e-16	1	0	A	164467857	A	A	164467857	3	1	3	1	0	0	0	0	1	0	0	0	5923	565	20	4	1798	4	FIGN	2	164467857	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1334618	164467857	78731516	64	444											
GRB14	2888	broad.mit.edu	37	chr2	165381587	165381587	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatatgctctggaaaaaaaTactgtcaaaaagacacagtt	18	9	6	8	0	2	1	1	0	1	1	2	2	2	2	1	1	2	2	1	1	7	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:165381587T>C	uc002ucl.2	-	5	1146	c.605A>G	c.(604-606)TAT>TGT	p.Y202C	GRB14_uc010zcv.1_Missense_Mutation_p.Y115C|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	202					blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						TGGAAAAAAATACTGTCAAAA	0.254													42	15					0	0	0	0	C	165381587	C	C	165381587	3	2	3	1	0	0	0	0	1	0	0	0	6796	1420	49	5	1057	5	GRB14	2	165381587	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	913730	165381587	77817786	65	445											
SCN1A	6323	broad.mit.edu	37	chr2	166854615	166854615	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggttcaaggtgaagaaggacCcaaagatgatgaaaataaca	19	6	11	5	0	1	5	1	3	0	2	1	6	1	6	1	3	1	1	1	3	7	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:166854615C>A	uc010zcz.1	-	23	4394	c.4376G>T	c.(4375-4377)GGG>GTG	p.G1459V	SCN1A_uc002udo.3_Missense_Mutation_p.G1339V|SCN1A_uc010fpk.2_Missense_Mutation_p.G1311V	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1470	Helical; Name=S6 of repeat III; (By similarity).|III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GAAGAAGGACCCAAAGATGAT	0.338													43	13					4.16155e-14	4.73414e-14	1	0	A	166854615	A	A	166854615	3	1	3	1	0	0	0	0	1	0	0	0	13979	623	22	4	1636	4	SCN1A	2	166854615	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1473028	166854615	76344758	66	446											
TTN	7273	broad.mit.edu	37	chr2	179454011	179454011	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatcttgacccttggtgatCttgttaagtctgtagcgtct	7	16	9	9	1	4	2	0	2	4	0	4	2	4	2	1	1	1	2	1	1	3	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:179454011C>A	uc010zfg.1	-	253	54961	c.54737G>T	c.(54736-54738)AGA>ATA	p.R18246I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R11941I|TTN_uc010zfi.1_Missense_Mutation_p.R11874I|TTN_uc010zfj.1_Missense_Mutation_p.R11749I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19173							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R11749T(1)|p.R18244T(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTGGTGATCTTGTTAAGTC	0.453													93	226					1.42366e-38	1.99744e-38	1	0	A	179454011	A	A	179454011	3	1	3	1	0	0	0	0	1	0	0	0	16803	913	32	2	45774	2	TTN	2	179454011	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	12599396	179454011	63745362	67	447											
TTN	7273	broad.mit.edu	37	chr2	179537203	179537203	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggactttctttggtacttCaggcactttaaagatacagt	10	15	9	7	0	2	1	1	0	1	1	2	2	2	2	0	3	2	2	0	3	4	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:179537203C>A	uc010zfg.1	-	149	31182	c.30958G>T	c.(30958-30960)GAA>TAA	p.E10320*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.E6981*|TTN_uc010fre.1_Intron|TTN_uc010zfk.1_5'Flank|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11247							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTACTTCAGGCACTTTA	0.373													115	370					1.19107e-50	1.75069e-50	1	0	A	179537203	A	A	179537203	4	1	3	1	0	0	0	0	0	1	0	0	16803	835	29	2	69683	2	TTN	2	179537203	Nonsense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	83192	179537203	63662170	68	448											
TTN	7273	broad.mit.edu	37	chr2	179553841	179553841	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaactttctcctctgggacGggtttcttaggcagagctgg	6	12	13	10	1	3	1	0	0	3	1	4	2	3	2	1	4	2	4	1	4	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:179553841G>C	uc010zfg.1	-	122	28526	c.28302C>G	c.(28300-28302)CCC>CCG	p.P9434P	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.P6095P|TTN_uc010fre.1_Silent_p.P545P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10361							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCTGGGACGGGTTTCTTAG	0.433													90	69					0	0	0	0	C	179553841	C	C	179553841	2	2	3	1	0	0	0	0	0	0	0	1	16803	1103	39	3		3	TTN	2	179553841	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	16638	179553841	63645532	69	449											
TTN	7273	broad.mit.edu	37	chr2	179583701	179583701	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgttcaaaagatggtggttCtagatattgcaaggcggaag	12	12	13	4	1	2	2	1	0	1	2	2	3	2	3	0	4	1	3	0	4	6	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:179583701C>G	uc010zfg.1	-	81	20719	c.20495_splice	c.e81-1	p.E6832_splice	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Splice_Site_p.E3493_splice	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATGGTGGTTCTAGATATTGC	0.438													23	17					0	0	0	0	G	179583701	G	G	179583701	5	3	3	1	0	0	0	0	0	0	1	0	16803	927	32	2	80419	2	TTN	2	179583701	Splice_Site	SNP	C	TCGA-BA-4076-01A-01D-1434-08	29860	179583701	63615672	70	450											
TTN	7273	broad.mit.edu	37	chr2	179590292	179590292	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	actggacaaaaataggctggGcgccttctatggatgcttgt	10	11	12	8	1	1	0	0	0	1	0	1	2	1	2	1	4	1	2	1	4	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:179590292G>T	uc010zfg.1	-	68	17131	c.16907C>A	c.(16906-16908)GCC>GAC	p.A5636D	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A2297D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6563							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATAGGCTGGGCGCCTTCTAT	0.428													68	53					3.31162e-33	4.49642e-33	1	0	T	179590292	T	T	179590292	3	4	3	1	0	0	0	0	1	0	0	0	16803	1203	42	4	84058	4	TTN	2	179590292	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	6591	179590292	63609081	71	451											
TTN	7273	broad.mit.edu	37	chr2	179659844	179659844	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcctcagatgaggaggccacGtagccctcttgcttccaagg	8	8	12	13	1	2	2	1	1	1	1	3	3	3	3	4	3	2	2	4	3	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:179659844G>T	uc010zfg.1	-	7	1274	c.1050C>A	c.(1048-1050)TAC>TAA	p.Y350*	TTN_uc010zfh.1_Nonsense_Mutation_p.Y350*|TTN_uc010zfi.1_Nonsense_Mutation_p.Y350*|TTN_uc010zfj.1_Nonsense_Mutation_p.Y350*|TTN_uc002unb.2_Nonsense_Mutation_p.Y350*|TTN_uc010frg.1_Nonsense_Mutation_p.Y24*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	350							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGAGGCCACGTAGCCCTCTT	0.557													49	102					2.68985e-26	3.48852e-26	1	0	T	179659844	T	T	179659844	4	4	3	1	0	0	0	0	0	1	0	0	16803	1140	40	3	110362	3	TTN	2	179659844	Nonsense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	69552	179659844	63539529	72	452											
DNAH7	56171	broad.mit.edu	37	chr2	196723252	196723252	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactctaatattggcaaggcAcctgccaggtcagcatcgca	11	8	10	12	1	2	0	1	0	1	0	3	1	2	0	2	3	2	4	2	3	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:196723252A>T	uc002utj.3	-	43	8114	c.8013T>A	c.(8011-8013)GGT>GGA	p.G2671G		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2671	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTGGCAAGGCACCTGCCAGGT	0.458													31	20					0	0	0	0	T	196723252	T	T	196723252	2	4	3	1	0	0	0	0	0	0	0	1	4628	146	6	5		5	DNAH7	2	196723252	Silent	SNP	A	TCGA-BA-4076-01A-01D-1434-08	17063408	196723252	46476121	73	453											
ABCA12	26154	broad.mit.edu	37	chr2	215917308	215917308	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttggactgggaaatactgtgGctgtaatcaaagaaggaaca	15	9	12	5	0	1	1	1	0	0	1	1	4	1	4	0	4	2	2	0	4	6	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:215917308G>A	uc002vew.2	-	5	630	c.410C>T	c.(409-411)GCC>GTC	p.A137V	ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	137					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AAATACTGTGGCTGTAATCAA	0.428													35	13					0	0	0	0	A	215917308	A	A	215917308	3	1	3	1	0	0	0	0	1	0	0	0	30	1217	42	4	7604	4	ABCA12	2	215917308	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	19194056	215917308	27282065	74	454											
SPHKAP	80309	broad.mit.edu	37	chr2	228883596	228883596	+	Frame_Shift_Del	DEL	G	-	-																															ttcctgacgacattttctgaGcacagggtctgagactttga																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:228883596delG	uc002vpq.2	-	7	2021	c.1974delC	c.(1972-1974)TGCfs	p.C658fs	SPHKAP_uc002vpp.2_Frame_Shift_Del_p.C658fs|SPHKAP_uc010zlx.1_Frame_Shift_Del_p.C658fs	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	658						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CATTTTCTGAGCACAGGGTCT	0.433													---	---	---								-	228883596	-	-	228883596	7	5	3	1	0	1	0	1	0	0	0	0	15114	963	34	0	3152	0	SPHKAP	2	228883596	Frame_Shift_Del	DEL	G	TCGA-BA-4076-01A-01D-1434-08	12966288	228883596	14315777	75	455											
TRIP12	9320	broad.mit.edu	37	chr2	230652326	230652326	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgctcggtcccgatcaaaTgcagttacataaaaaagcat	15	10	7	9	2	1	0	1	0	0	0	3	1	2	0	1	1	4	4	1	1	5	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr2:230652326T>C	uc002vpw.1	-	32	4774	c.4665A>G	c.(4663-4665)GCA>GCG	p.A1555A	TRIP12_uc002vpx.1_Silent_p.A1603A|TRIP12_uc002vpy.1_Silent_p.A1285A	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1555	K-box.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CCCGATCAAATGCAGTTACAT	0.378													53	20					0	0	0	0	C	230652326	C	C	230652326	2	2	3	1	0	0	0	0	0	0	0	1	16623	1451	51	5		5	TRIP12	2	230652326	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	1768730	230652326	12547047	76	456											
GRM7	2917	broad.mit.edu	37	chr3	7494344	7494344	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagcaggagggtaaagtcCagttcgtgattgacgcagtc	11	9	14	7	2	0	3	0	3	0	0	3	4	1	4	1	2	1	4	1	2	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:7494344C>A	uc003bqm.2	+	6	1499	c.1225C>A	c.(1225-1227)CAG>AAG	p.Q409K	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.Q409K|GRM7_uc003bql.2_Missense_Mutation_p.Q409K|GRM7_uc003bqn.1_5'UTR|GRM7_uc010hch.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	409	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GGGTAAAGTCCAGTTCGTGAT	0.413													27	18					3.73148e-12	4.15306e-12	1	0	A	7494344	A	A	7494344	3	1	3	1	0	0	0	0	1	0	0	0	6841	595	21	4	1247	4	GRM7	3	7494344	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08		7494344	190528086	77	457											
GRM7	2917	broad.mit.edu	37	chr3	7494377	7494377	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgcagtctatgctatggctCacgcccttcaccacatgaac	10	9	7	15	2	3	1	2	1	1	0	3	1	3	1	2	1	2	3	2	1	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:7494377C>G	uc003bqm.2	+	6	1532	c.1258C>G	c.(1258-1260)CAC>GAC	p.H420D	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.H420D|GRM7_uc003bql.2_Missense_Mutation_p.H420D|GRM7_uc003bqn.1_Missense_Mutation_p.H3D|GRM7_uc010hch.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	420	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TGCTATGGCTCACGCCCTTCA	0.488													18	12					0	0	0	0	G	7494377	G	G	7494377	3	3	3	1	0	0	0	0	1	0	0	0	6841	826	29	2	1280	2	GRM7	3	7494377	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	33	7494377	190528053	78	458											
ATP2B2	491	broad.mit.edu	37	chr3	10428194	10428194	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggccatcccccttcttcaCacctgtgtgatgatttttga	8	14	7	12	0	2	3	1	3	1	0	3	3	3	3	4	1	0	0	4	1	1	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:10428194C>A	uc003bvt.2	-	7	1349	c.910G>T	c.(910-912)GTG>TTG	p.V304L	ATP2B2_uc003bvv.2_Intron|ATP2B2_uc003bvw.2_Intron|ATP2B2_uc010hdo.2_Intron	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	304	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CCCTTCTTCACACCTGTGTGA	0.398													50	23					1.78197e-24	2.25423e-24	1	0	A	10428194	A	A	10428194	3	1	3	1	0	0	0	0	1	0	0	0	1142	478	17	4	2889	4	ATP2B2	3	10428194	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2933817	10428194	187594236	79	459											
XCR1	2829	broad.mit.edu	37	chr3	46062615	46062615	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagcagcagtgggagaaggcGaggttgcggcagatgagcag	12	4	19	6	2	0	3	0	1	0	2	0	5	0	3	0	4	4	5	0	4	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:46062615G>A	uc003cpe.2	-	3	1049	c.825C>T	c.(823-825)CTC>CTT	p.L275L	uc003cpd.1_5'Flank|XCR1_uc003cpf.2_Silent_p.L275L	NM_005283	NP_005274	P46094	XCR1_HUMAN	XC chemokine receptor 1	275	Helical; Name=7; (Potential).				chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GGGAGAAGGCGAGGTTGCGGC	0.567													23	7					0	0	0	0	A	46062615	A	A	46062615	2	1	3	1	0	0	0	0	0	0	0	1	17493	1045	37	1		1	XCR1	3	46062615	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	35634421	46062615	151959815	80	460											
LOC646498	646498	broad.mit.edu	37	chr3	49227304	49227304	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttttccaccctgtctgtaGgggaaagatctgacatctca	9	13	8	11	0	4	2	1	1	4	1	6	3	5	3	2	2	0	1	2	2	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:49227304G>T	uc011bcj.1	-	1	124	c.118C>A	c.(118-120)CTA>ATA	p.L40I		NM_001080528	NP_001073997			hypothetical LOC646498												0				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.00221)|KIRC - Kidney renal clear cell carcinoma(197;0.00247)		CCTGTCTGTAGGGGAAAGATC	0.522													118	35					1.4482e-55	2.14909e-55	1	0	T	49227304	T	T	49227304	3	4	3	1	0	0	0	0	1	0	0	0	8934	1015	35	4		4	LOC646498	3	49227304	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	3164689	49227304	148795126	81	461											
ABHD14A	25864	broad.mit.edu	37	chr3	52011936	52011936	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggtagccctgctgggccTgagtctgctgctcatgctcc	4	10	12	15	0	2	1	1	1	1	0	3	1	3	1	4	2	5	5	4	2	1	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:52011936T>C	uc003dco.2	+	2	229	c.119T>C	c.(118-120)CTG>CCG	p.L40P	ABHD14B_uc003dcn.2_Intron|ABHD14A_uc010hlz.2_Missense_Mutation_p.L40P|ACY1_uc011bea.1_5'UTR	NM_015407	NP_056222	Q9BUJ0	ABHEA_HUMAN	abhydrolase domain containing 14A	40	Helical; Signal-anchor for type II membrane protein; (Potential).					cytoplasm|integral to membrane	hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CTGCTGGGCCTGAGTCTGCTG	0.612													4	202					0	0	0	0	C	52011936	C	C	52011936	3	2	3	1	0	0	0	0	1	0	0	0	79	1580	55	5	125	5	ABHD14A	3	52011936	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	2784632	52011936	146010494	82	462											
LMOD3	56203	broad.mit.edu	37	chr3	69168975	69168975	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatttctaatttgttccttTgctttgccttcctcttctct	4	22	3	12	0	3	0	0	0	3	0	6	0	5	0	3	0	2	2	3	0	2	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:69168975T>C	uc003dns.2	-	2	740	c.531A>G	c.(529-531)GCA>GCG	p.A177A	LMOD3_uc003dnt.2_Silent_p.A177A	NM_198271	NP_938012	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	177	Glu-rich.					cytoplasm|cytoskeleton	tropomyosin binding			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		TTTGTTCCTTTGCTTTGCCTT	0.318													10	5					0	0	0	0	C	69168975	C	C	69168975	2	2	3	1	0	0	0	0	0	0	0	1	8900	1799	63	5		5	LMOD3	3	69168975	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	17157039	69168975	128853455	83	463											
CADM2	253559	broad.mit.edu	37	chr3	85851229	85851229	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtttccactaacacagaatGtaaccgttgttgaaggtgga	13	11	10	7	1	0	2	0	1	0	1	1	3	1	3	2	2	2	4	2	2	4	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:85851229G>T	uc003dqj.2	+	2	720	c.94G>T	c.(94-96)GTA>TTA	p.V32L	CADM2_uc003dqk.2_Missense_Mutation_p.V41L|CADM2_uc003dql.2_Missense_Mutation_p.V34L	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	32	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		AACACAGAATGTAACCGTTGT	0.403													53	10					1.4709e-25	1.89174e-25	1	0	T	85851229	T	T	85851229	3	4	3	1	0	0	0	0	1	0	0	0	2579	1377	48	4	171	4	CADM2	3	85851229	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	16682254	85851229	112171201	84	464											
PROS1	5627	broad.mit.edu	37	chr3	93615489	93615489	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actgctccgccaagtaaagtAattcatactttgtgtcaagg	12	12	8	9	1	2	0	2	0	0	0	3	0	3	0	2	1	2	3	2	1	6	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:93615489A>T	uc003drb.3	-	9	1237	c.896T>A	c.(895-897)TTA>TAA	p.L299*	PROS1_uc010hoo.2_Nonsense_Mutation_p.L168*|PROS1_uc003dqz.3_Nonsense_Mutation_p.L168*	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	299	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	CAAGTAAAGTAATTCATACTT	0.358													79	242					0	0	0	0	T	93615489	T	T	93615489	4	4	3	1	0	0	0	0	0	1	0	0	12620	372	13	5	1162	5	PROS1	3	93615489	Nonsense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	7764260	93615489	104406941	85	465											
ST3GAL6	10402	broad.mit.edu	37	chr3	98507004	98507004	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accctaatacgacagtgattCtcactgcttttaagccacat	12	12	5	12	1	1	1	1	1	1	0	2	2	1	1	2	0	3	1	2	0	3	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:98507004C>G	uc003dsz.2	+	7	792	c.556C>G	c.(556-558)CTC>GTC	p.L186V	ST3GAL6_uc003dsy.2_Missense_Mutation_p.L100V|ST3GAL6_uc003dta.2_Missense_Mutation_p.L68V|ST3GAL6_uc003dtb.2_Missense_Mutation_p.L42V|ST3GAL6_uc003dtc.2_Missense_Mutation_p.L186V|ST3GAL6_uc010hpd.2_Missense_Mutation_p.L239V	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	186	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						GACAGTGATTCTCACTGCTTT	0.383													50	124					0	0	0	0	G	98507004	G	G	98507004	3	3	3	1	0	0	0	0	1	0	0	0	15285	913	32	2	578	2	ST3GAL6	3	98507004	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	4891515	98507004	99515426	86	466											
GPR128	84873	broad.mit.edu	37	chr3	100349575	100349576	+	Frame_Shift_Ins	INS	-	TT	TT																															ttgtgaaaatagtacctataINStgggttttacttttgccaga																								rs146877111		TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:100349575_100349576insTT	uc003duc.2	+	3	524_525	c.256_257insTT	c.(256-258)ATGfs	p.M86fs		NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	86	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						TAGTACCTATATGGGTTTTACT	0.312													---	---	---								TT	100349576	TT	TT	100349575	7	5	3	1	0	1	1	0	0	0	0	0	6679	449	16	0	266	0	GPR128	3	100349575	Frame_Shift_Ins	INS	-	TCGA-BA-4076-01A-01D-1434-08	1842571	100349575	97672855	87	467											
IMPG2	50939	broad.mit.edu	37	chr3	100962535	100962535	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccttctgtgggccaagcCacactaaccatctctgtgga	8	10	8	15	0	2	0	0	0	2	0	4	1	3	1	5	2	2	0	5	2	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:100962535C>A	uc003duq.1	-	13	2843	c.2640G>T	c.(2638-2640)GTG>GTT	p.V880V	IMPG2_uc011bhe.1_Silent_p.V743V	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	880	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TGGGCCAAGCCACACTAACCA	0.458													69	41					5.45122e-27	7.10962e-27	1	0	A	100962535	A	A	100962535	2	1	3	1	0	0	0	0	0	0	0	1	7768	581	21	4		4	IMPG2	3	100962535	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	612960	100962535	97059895	88	468											
MYH15	22989	broad.mit.edu	37	chr3	108189618	108189618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcttggcatccagggccCtgttgatccgtgccactagc	7	9	11	14	1	0	1	0	1	0	0	2	1	2	1	4	2	3	3	4	2	1	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:108189618C>T	uc003dxa.1	-	14	1427	c.1370G>A	c.(1369-1371)AGG>AAG	p.R457K		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	457	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						ATCCAGGGCCCTGTTGATCCG	0.458													27	53					0	0	0	0	T	108189618	T	T	108189618	3	4	3	1	0	0	0	0	1	0	0	0	10087	681	24	4	4586	4	MYH15	3	108189618	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	7227083	108189618	89832812	89	469											
TRAT1	50852	broad.mit.edu	37	chr3	108572466	108572466	+	Splice_Site	DEL	G	-	-																															attaacatccctttcttttaGgcaaccaatgaaacacagat																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:108572466delG	uc003dxi.1	+	6	448	c.304_splice	c.e6-1	p.A102_splice	TRAT1_uc010hpx.1_Splice_Site_p.A65_splice	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule						cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						CTTTCTTTTAGGCAACCAATG	0.403													---	---	---								-	108572466	-	-	108572466	8	5	3	1	0	1	0	1	0	0	1	0	16533	1014	35	0	325	0	TRAT1	3	108572466	Splice_Site	DEL	G	TCGA-BA-4076-01A-01D-1434-08	382848	108572466	89449964	90	470											
MORC1	27136	broad.mit.edu	37	chr3	108813861	108813861	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgcaaatttctggggatCatctgtgacagattctctgg	9	14	10	8	0	4	2	1	1	3	1	5	3	4	3	0	3	1	1	0	3	1	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:108813861C>A	uc003dxl.2	-	7	565	c.478G>T	c.(478-480)GAT>TAT	p.D160Y	MORC1_uc011bhn.1_Missense_Mutation_p.D160Y	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	160					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TTCTGGGGATCATCTGTGACA	0.313													24	89					7.92952e-12	8.72059e-12	1	0	A	108813861	A	A	108813861	3	1	3	1	0	0	0	0	1	0	0	0	9754	826	29	2	2564	2	MORC1	3	108813861	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	241395	108813861	89208569	91	471											
GTF2E1	2960	broad.mit.edu	37	chr3	120489717	120489717	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcgggagacagaggatgtGaacttggcctatgaaatact	12	10	12	7	1	0	4	0	2	0	2	1	6	0	5	1	3	2	0	1	3	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:120489717G>T	uc003edz.3	+	3	705	c.591G>T	c.(589-591)GTG>GTT	p.V197V		NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	197					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		CAGAGGATGTGAACTTGGCCT	0.443													157	467					3.11516e-78	4.72892e-78	1	0	T	120489717	T	T	120489717	2	4	3	1	0	0	0	0	0	0	0	1	6895	1277	45	2		2	GTF2E1	3	120489717	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	11675856	120489717	77532713	92	472											
HEG1	57493	broad.mit.edu	37	chr3	124738111	124738111	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatggaaaaactcactcgaaCgttctccacgtggtgctgat	12	10	9	10	3	2	1	1	1	1	0	4	3	2	2	1	2	3	2	1	2	4	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:124738111C>A	uc003ehs.3	-	5	1651	c.1583G>T	c.(1582-1584)CGT>CTT	p.R528L	HEG1_uc011bke.1_Missense_Mutation_p.R528L	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	528	Extracellular (Potential).|Ser-rich.					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						CTCACTCGAACGTTCTCCACG	0.453													3	91					0.00909568	0.00927599	1	0	A	124738111	A	A	124738111	3	1	3	1	0	0	0	0	1	0	0	0	7083	536	19	3	2614	3	HEG1	3	124738111	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	4248394	124738111	73284319	93	473											
KIAA1257	57501	broad.mit.edu	37	chr3	128712028	128712028	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagactcctgggccctggcCttggccttcaggtgttcctc	3	12	11	15	0	2	1	2	0	0	1	5	1	4	1	5	4	0	1	5	4	0	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:128712028C>T	uc003elj.3	-	2	316	c.120G>A	c.(118-120)AAG>AAA	p.K40K	KIAA1257_uc003elg.1_Silent_p.K40K|KIAA1257_uc003eli.3_5'Flank	NM_020741	NP_065792	Q9ULG3	K1257_HUMAN	hypothetical protein LOC57501	40											0						GGGCCCTGGCCTTGGCCTTCA	0.612													5	166					0	0	0	0	T	128712028	T	T	128712028	2	4	3	1	0	0	0	0	0	0	0	1	8257	680	24	4		4	KIAA1257	3	128712028	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	3973917	128712028	69310402	94	474											
PLXND1	23129	broad.mit.edu	37	chr3	129293227	129293227	+	Frame_Shift_Del	DEL	C	-	-																															ccagccatgggctgcagaggCccccgcaggcggcagccatc																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:129293227delC	uc003emx.2	-	12	2737	c.2637delG	c.(2635-2637)GGGfs	p.G879fs		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	879	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						GCTGCAGAGGCCCCCGCAGGC	0.687													---	---	---								-	129293227	-	-	129293227	7	5	3	1	0	1	0	1	0	0	0	0	12182	726	26	0	3240	0	PLXND1	3	129293227	Frame_Shift_Del	DEL	C	TCGA-BA-4076-01A-01D-1434-08	581199	129293227	68729203	95	475											
NPHP3	27031	broad.mit.edu	37	chr3	132408077	132408077	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgtctttgccaacaaactgCcaataactcagcaactcagc	13	10	5	13	0	3	0	2	0	1	0	3	0	3	0	2	0	8	1	2	0	5	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:132408077C>T	uc003epe.1	-	20	2801	c.2724G>A	c.(2722-2724)TGG>TGA	p.W908*	NPHP3_uc003epd.1_Nonsense_Mutation_p.W150*	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	908	TPR 2.				maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CAACAAACTGCCAATAACTCA	0.383													76	166					0	0	0	0	T	132408077	T	T	132408077	4	4	3	1	0	0	0	0	0	1	0	0	10634	740	26	4	1300	4	NPHP3	3	132408077	Nonsense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	3114850	132408077	65614353	96	476											
PRR23C	389152	broad.mit.edu	37	chr3	138763109	138763109	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccacttccaggccggcagaCcagtcgccctgcgctcctga	6	7	10	18	3	0	2	0	1	0	1	4	2	3	2	6	2	1	2	6	2	0	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:138763109C>T	uc011bmt.1	-	1	626	c.354G>A	c.(352-354)TGG>TGA	p.W118*		NM_001134657	NP_001128129	Q6ZRP0	PR23C_HUMAN	proline rich 23C	118										skin(1)	1						GGCCGGCAGACCAGTCGCCCT	0.637													6	24					0	0	0	0	T	138763109	T	T	138763109	4	4	3	1	0	0	0	0	0	1	0	0	12658	508	18	4	438	4	PRR23C	3	138763109	Nonsense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	6355032	138763109	59259321	97	477											
HLTF	6596	broad.mit.edu	37	chr3	148778569	148778569	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatctattacatgttaccttTcattttctgcggcaattcac	10	17	4	10	1	4	0	2	0	2	0	4	0	4	0	1	1	3	2	1	1	5	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:148778569T>G	uc003ewq.1	-	11	1455	c.1237A>C	c.(1237-1239)AAA>CAA	p.K413Q	HLTF_uc003ewr.1_Missense_Mutation_p.K413Q|HLTF_uc003ews.1_Missense_Mutation_p.K413Q|HLTF_uc010hve.1_Missense_Mutation_p.K413Q	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	413					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			ATGTTACCTTTCATTTTCTGC	0.299													38	69					0	0	0	0	G	148778569	G	G	148778569	3	3	3	1	0	0	0	0	1	0	0	0	7254	1792	62	5	1852	5	HLTF	3	148778569	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	10015460	148778569	49243861	98	478											
HLTF	6596	broad.mit.edu	37	chr3	148792018	148792018	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttactttttggtgcaggaccCaatttaaatccatgtttctt	9	18	6	8	0	1	0	0	0	1	0	2	1	2	1	2	2	2	2	2	2	4	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:148792018C>A	uc003ewq.1	-	4	731	c.513G>T	c.(511-513)TTG>TTT	p.L171F	HLTF_uc003ewr.1_Missense_Mutation_p.L171F|HLTF_uc003ews.1_Missense_Mutation_p.L171F|HLTF_uc010hve.1_Missense_Mutation_p.L171F	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	171					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GTGCAGGACCCAATTTAAATC	0.338													21	100					4.35082e-09	4.69564e-09	1	0	A	148792018	A	A	148792018	3	1	3	1	0	0	0	0	1	0	0	0	7254	593	21	4	2604	4	HLTF	3	148792018	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	13449	148792018	49230412	99	479											
GPR149	344758	broad.mit.edu	37	chr3	154138918	154138918	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgagacagtcttctttcTggcccttcagaaaaggtagt	10	13	9	9	0	5	2	2	1	3	2	5	3	5	2	1	2	0	1	1	2	3	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:154138918T>C	uc003faa.2	-	3	1633	c.1533A>G	c.(1531-1533)CCA>CCG	p.P511P		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	511	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GTCTTCTTTCTGGCCCTTCAG	0.408													79	163					0	0	0	0	C	154138918	C	C	154138918	2	2	3	1	0	0	0	0	0	0	0	1	6692	1567	55	5		5	GPR149	3	154138918	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	5346900	154138918	43883512	100	480											
IQCJ	654502	broad.mit.edu	37	chr3	158983064	158983064	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttggaggttgcagtcacctGgggacaagttgcctggtgga	7	10	16	8	0	1	0	1	0	0	0	1	3	1	3	2	6	2	3	2	6	1	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:158983064G>A	uc003fcp.1	+	5	457	c.352G>A	c.(352-354)GGG>AGG	p.G118R	SCHIP1_uc003fcq.1_Intron|SCHIP1_uc003fcr.1_Intron|IQCJ_uc010hvy.1_Missense_Mutation_p.G91R	NM_001042705	NP_001036170	Q1A5X6	IQCJ_HUMAN	IQ motif containing J isoform CaMBPv1	118											0			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			GCAGTCACCTGGGGACAAGTT	0.493													215	150					0	0	0	0	A	158983064	A	A	158983064	3	1	3	1	0	0	0	0	1	0	0	0	7851	1348	47	4	418	4	IQCJ	3	158983064	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	4844146	158983064	39039366	101	481											
SI	6476	broad.mit.edu	37	chr3	164737396	164737396	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atgttggtacctacaccaggGggttggtctcttgtgaacat	8	13	12	8	0	1	1	0	1	1	0	2	1	1	1	2	4	3	3	2	4	3	5	rs150297357	byFrequency	TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:164737396G>T	uc003fei.2	-	28	3479	c.3417C>A	c.(3415-3417)CCC>CCA	p.P1139P		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1139	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTACACCAGGGGGTTGGTCTC	0.443										HNSCC(35;0.089)			82	76					1.02218e-41	1.45622e-41	1	0	T	164737396	T	T	164737396	2	4	3	1	0	0	0	0	0	0	0	1	14362	1219	43	4		4	SI	3	164737396	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	5754332	164737396	33285034	102	482											
SI	6476	broad.mit.edu	37	chr3	164739083	164739083	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttccttgatttccacatcaTaaagtctgtcttcataagta	11	17	4	9	0	4	1	2	1	2	0	6	1	6	1	2	0	0	1	2	0	4	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:164739083T>C	uc003fei.2	-	27	3250	c.3188A>G	c.(3187-3189)TAT>TGT	p.Y1063C		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1063	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTCCACATCATAAAGTCTGTC	0.353										HNSCC(35;0.089)			142	330					0	0	0	0	C	164739083	C	C	164739083	3	2	3	1	0	0	0	0	1	0	0	0	14362	1406	49	5	2383	5	SI	3	164739083	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	1687	164739083	33283347	103	483											
EIF5A2	56648	broad.mit.edu	37	chr3	170624851	170624851	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaatatcttcatattttttgCccgtgaaaatatcaattcca	14	16	3	8	1	3	1	2	1	1	0	4	1	4	1	2	0	1	0	2	0	7	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:170624851C>T	uc003fhd.2	-	3	327	c.197G>A	c.(196-198)GGC>GAC	p.G66D		NM_020390	NP_065123	Q9GZV4	IF5A2_HUMAN	eIF-5A2 protein	66					mRNA transport|peptidyl-lysine modification to hypusine|polyamine homeostasis|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein transport|spermatogenesis|translational frameshifting|transmembrane transport	cytosol|endoplasmic reticulum membrane|nuclear pore	protein binding|ribosome binding|translation elongation factor activity				0	all_cancers(22;1.61e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;9.8e-16)|Lung(28;4.28e-15)			ATATTTTTTGCCCGTGAAAAT	0.343													4	132					0	0	0	0	T	170624851	T	T	170624851	3	4	3	1	0	0	0	0	1	0	0	0	5066	739	26	4	276	4	EIF5A2	3	170624851	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5885768	170624851	27397579	104	484											
MFN1	55669	broad.mit.edu	37	chr3	179095131	179095131	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaattttcatattttcaGgtttcatgtgcaatgacaga	13	15	6	7	0	3	2	3	1	0	1	3	2	3	2	1	1	1	2	1	1	4	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:179095131G>A	uc003fjs.2	+	12	1351	c.1225_splice	c.e12-1	p.V409_splice	MFN1_uc010hxb.2_Splice_Site|MFN1_uc003fjt.2_Splice_Site_p.V437_splice|MFN1_uc010hxc.2_Splice_Site_p.V262_splice	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1						mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CATATTTTCAGGTTTCATGTG	0.239													44	101					0	0	0	0	A	179095131	A	A	179095131	5	1	3	1	0	0	0	0	0	0	1	0	9576	1014	35	4	1266	4	MFN1	3	179095131	Splice_Site	SNP	G	TCGA-BA-4076-01A-01D-1434-08	8470280	179095131	18927299	105	485											
CHRD	8646	broad.mit.edu	37	chr3	184099067	184099067	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccctggcagggtcagctgCaagaacatcaaaccagagtg	12	5	13	11	0	2	2	2	0	0	2	2	2	2	2	2	3	4	3	2	3	3	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:184099067C>G	uc003fov.2	+	3	543	c.297C>G	c.(295-297)TGC>TGG	p.C99W	CHRD_uc003fow.2_5'UTR|CHRD_uc003fox.2_Missense_Mutation_p.C99W|CHRD_uc003foy.2_5'UTR|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'Flank	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	99	VWFC 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGGTCAGCTGCAAGAACATCA	0.647													21	43					0	0	0	0	G	184099067	G	G	184099067	3	3	3	1	0	0	0	0	1	0	0	0	3387	718	25	4	307	4	CHRD	3	184099067	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5003936	184099067	13923363	106	486											
DNAJB11	51726	broad.mit.edu	37	chr3	186299209	186299209	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctcctggcaaacggaagtGcaattgtcggcaagagatgc	11	7	14	9	2	0	1	0	0	0	1	2	3	1	2	1	4	3	4	1	4	4	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr3:186299209G>T	uc003fqi.2	+	5	726	c.506G>T	c.(505-507)TGC>TTC	p.C169F		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	169				C->S: Drastic loss of interaction with denatured substrates.	protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		AAACGGAAGTGCAATTGTCGG	0.517													55	145					5.82388e-19	6.96759e-19	1	0	T	186299209	T	T	186299209	3	4	3	1	0	0	0	0	1	0	0	0	4638	1319	46	4	524	4	DNAJB11	3	186299209	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	2200142	186299209	11723221	107	487											
GUF1	60558	broad.mit.edu	37	chr4	44688653	44688653	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccaaaggagataaaattgtAtctgcacatactcaaaagac	18	9	6	8	0	2	2	1	0	1	2	3	3	3	2	1	1	2	2	1	1	7	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:44688653A>G	uc003gww.3	+	8	1068	c.861A>G	c.(859-861)GTA>GTG	p.V287V	GUF1_uc010ifz.1_RNA	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	287					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						ATAAAATTGTATCTGCACATA	0.368													89	38					0	0	0	0	G	44688653	G	G	44688653	2	3	3	1	0	0	0	0	0	0	0	1	6938	436	16	5		5	GUF1	4	44688653	Silent	SNP	A	TCGA-BA-4076-01A-01D-1434-08		44688653	146465623	108	488											
KIAA1211	57482	broad.mit.edu	37	chr4	57173804	57173804	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttagaagaggatctgttccTgaccagtcccatggaaattg	11	11	10	9	0	1	3	0	1	1	2	3	5	3	5	3	2	0	1	3	2	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:57173804T>A	uc003hbk.2	+	5	615	c.224T>A	c.(223-225)CTG>CAG	p.L75Q	KIAA1211_uc010iha.2_Missense_Mutation_p.L68Q|KIAA1211_uc011bzz.1_5'Flank|KIAA1211_uc003hbl.2_5'Flank|KIAA1211_uc003hbm.1_5'Flank	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	75										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GATCTGTTCCTGACCAGTCCC	0.493													36	38					0	0	0	0	A	57173804	A	A	57173804	3	1	3	1	0	0	0	0	1	0	0	0	8254	1580	55	5	230	5	KIAA1211	4	57173804	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	12485151	57173804	133980472	109	489											
TECRL	253017	broad.mit.edu	37	chr4	65175550	65175550	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagcatcctcaccattatCaaatttttcaaaggtgtgtg	13	13	6	9	0	3	0	3	0	0	0	4	0	4	0	2	1	1	1	2	1	4	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:65175550C>G	uc003hcv.2	-	6	760	c.651G>C	c.(649-651)TTG>TTC	p.L217F	TECRL_uc003hcw.2_Missense_Mutation_p.L217F	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	217	Helical; (Potential).				lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						TCACCATTATCAAATTTTTCA	0.338													85	139					0	0	0	0	G	65175550	G	G	65175550	3	3	3	1	0	0	0	0	1	0	0	0	15812	825	29	2	468	2	TECRL	4	65175550	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	8001746	65175550	125978726	110	490											
UGT2B10	7365	broad.mit.edu	37	chr4	69682013	69682013	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaatatcatcatgcaattGgttaagagattgtcagaaat	16	12	9	4	0	3	3	3	0	0	3	3	5	3	3	0	1	1	2	0	1	5	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:69682013G>T	uc003hee.2	+	1	301	c.276G>T	c.(274-276)TTG>TTT	p.L92F	UGT2B10_uc011cam.1_Missense_Mutation_p.L92F	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	92					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TCATGCAATTGGTTAAGAGAT	0.313													41	60					2.26627e-22	2.80557e-22	1	0	T	69682013	T	T	69682013	3	4	3	1	0	0	0	0	1	0	0	0	17024	1339	47	4	278	4	UGT2B10	4	69682013	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	4506463	69682013	121472263	111	491											
CSN1S1	1446	broad.mit.edu	37	chr4	70804897	70804897	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatttctttcttttagaagAtggaatccagcatcagttca	12	15	7	7	0	4	3	2	0	2	3	5	4	5	4	1	1	1	2	1	1	3	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:70804897A>G	uc003hep.1	+	10	296	c.247A>G	c.(247-249)ATG>GTG	p.M83V	CSN1S1_uc003heq.1_Missense_Mutation_p.M82V|CSN1S1_uc003her.1_Missense_Mutation_p.M83V	NM_001890	NP_001881	P47710	CASA1_HUMAN	casein alpha s1 isoform 1	83						extracellular region	protein binding|transporter activity				0						CTTTTAGAAGATGGAATCCAG	0.328													50	73					0	0	0	0	G	70804897	G	G	70804897	3	3	3	1	0	0	0	0	1	0	0	0	3964	333	12	5	281	5	CSN1S1	4	70804897	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	1122884	70804897	120349379	112	492											
ADAMTS3	9508	broad.mit.edu	37	chr4	73164099	73164099	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgattgtaggtacagagtCttcatggatgatgtacttat	10	16	11	4	0	2	3	1	2	1	1	2	4	2	4	0	2	2	4	0	2	4	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:73164099C>G	uc003hgk.1	-	18	2522	c.2485G>C	c.(2485-2487)GAC>CAC	p.D829H	ADAMTS3_uc003hgl.2_Missense_Mutation_p.D170H	NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	829	Spacer.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGTACAGAGTCTTCATGGATG	0.403													84	121					0	0	0	0	G	73164099	G	G	73164099	3	3	3	1	0	0	0	0	1	0	0	0	267	913	32	2	1152	2	ADAMTS3	4	73164099	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2359202	73164099	117990177	113	493											
ALB	213	broad.mit.edu	37	chr4	74285323	74285324	+	Missense_Mutation	DNP	GG	TT	TT																															tttgtagagaagtgctgcaaGgctgacgataaggagacctg																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:74285323_74285324GG>TT	uc003hgs.3	+	13	1825_1826	c.1752_1753GG>TT	c.(1750-1755)AAGGCT>AATTCT	p.584_585KA>NS	ALB_uc003hgw.3_Missense_Mutation_p.392_393KA>NS|ALB_uc011cbe.1_Missense_Mutation_p.263_264KA>NS|ALB_uc003hgt.3_Missense_Mutation_p.584_585KA>NS|ALB_uc010iii.2_Missense_Mutation_p.469_470KA>NS|ALB_uc003hgu.3_Missense_Mutation_p.434_435KA>NS|ALB_uc003hgv.3_Missense_Mutation_p.263_264KA>NS|ALB_uc011cbf.1_Missense_Mutation_p.474_475KA>NS|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Missense_Mutation_p.263_264KA>NS	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	584_585	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AGTGCTGCAAGGCTGACGATAA	0.441													63	133					0	0	0	0	TT	74285324	TT	TT	74285323	3	4	3	1	0	0	0	0	1	0	0	0	486	991	35	4	1802	4	ALB	4	74285323	Missense_Mutation	DNP	GG	TCGA-BA-4076-01A-01D-1434-08	1121224	74285323	116868953	114	494											
NAA11	84779	broad.mit.edu	37	chr4	80246866	80246866	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcctccattttggccagaaCatagcccacaatcttcccgt	9	11	5	16	1	1	1	0	0	1	1	4	1	4	1	5	1	2	0	5	1	3	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:80246866C>T	uc003hlt.3	-	1	306	c.166G>A	c.(166-168)GTT>ATT	p.V56I		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	56	Interaction with NAA15 (By similarity).|N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						TTGGCCAGAACATAGCCCACA	0.532													65	134					0	0	0	0	T	80246866	T	T	80246866	3	4	3	1	0	0	0	0	1	0	0	0	10170	478	17	4	527	4	NAA11	4	80246866	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5961543	80246866	110907410	115	495											
ANTXR2	118429	broad.mit.edu	37	chr4	80898813	80898813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgcatcaaagaaacccggtCatactgccgcctcaacaaag	14	6	7	14	3	3	1	3	0	0	1	4	1	3	1	3	1	4	1	3	1	5	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:80898813C>T	uc003hlz.3	-	16	2153	c.1390G>A	c.(1390-1392)GAC>AAC	p.D464N	ANTXR2_uc003hly.3_Missense_Mutation_p.D464N|ANTXR2_uc003hlx.1_RNA|ANTXR2_uc010ijn.2_Missense_Mutation_p.D361N	NM_001145794	NP_001139266	P58335	ANTR2_HUMAN	anthrax toxin receptor 2 isoform 2	464	Cytoplasmic (Potential).					endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			ovary(1)	1						GAAACCCGGTCATACTGCCGC	0.448									Juvenile_Hyaline_Fibromatosis				6	8					0	0	0	0	T	80898813	T	T	80898813	3	4	3	1	0	0	0	0	1	0	0	0	712	826	29	2	126	2	ANTXR2	4	80898813	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	651947	80898813	110255463	116	496											
ENOPH1	58478	broad.mit.edu	37	chr4	83375980	83375980	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcacagaaactgttattcggGcattctacggagggagatat	12	10	12	7	2	1	2	0	0	1	2	2	4	1	3	0	3	2	3	0	3	4	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:83375980G>A	uc003hmv.2	+	4	752	c.495G>A	c.(493-495)GGG>GGA	p.G165G	ENOPH1_uc003hmw.2_Silent_p.G77G|ENOPH1_uc003hmx.2_Silent_p.G19G	NM_021204	NP_067027	Q9UHY7	ENOPH_HUMAN	enolase-phosphatase 1	165					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity				0						TGTTATTCGGGCATTCTACGG	0.418													5	214					0	0	0	0	A	83375980	A	A	83375980	2	1	3	1	0	0	0	0	0	0	0	1	5148	1190	42	4		4	ENOPH1	4	83375980	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	2477167	83375980	107778296	117	497											
GPRIN3	285513	broad.mit.edu	37	chr4	90170272	90170272	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggctggtggagacggatctGctctcgacactcgccactgc	6	8	14	13	3	2	1	0	0	2	1	4	4	2	2	1	4	2	2	1	4	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:90170272G>T	uc003hsm.1	-	2	1509	c.990C>A	c.(988-990)AGC>AGA	p.S330R		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	330										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		AGACGGATCTGCTCTCGACAC	0.537													53	100					1.4374e-25	1.8538e-25	1	0	T	90170272	T	T	90170272	3	4	3	1	0	0	0	0	1	0	0	0	6770	1310	46	4	1344	4	GPRIN3	4	90170272	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	6794292	90170272	100984004	118	498											
DKK2	27123	broad.mit.edu	37	chr4	107845325	107845325	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacagcaaaacccttcaatgCagtctgatgatcgtaggcag	13	8	9	11	1	2	2	1	2	1	0	3	2	2	2	1	1	3	4	1	1	4	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:107845325C>A	uc003hyi.2	-	4	1271	c.566G>T	c.(565-567)TGC>TTC	p.C189F	DKK2_uc003hyj.1_3'UTR	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	189	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CCCTTCAATGCAGTCTGATGA	0.453													51	76					4.00472e-15	4.6124e-15	1	0	A	107845325	A	A	107845325	3	1	3	1	0	0	0	0	1	0	0	0	4567	710	25	4	217	4	DKK2	4	107845325	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	17675053	107845325	83308951	119	499											
DKK2	27123	broad.mit.edu	37	chr4	107845853	107845853	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttcagtaactgggatacaGatgcctggagatgatcatat	12	12	10	7	0	2	3	2	1	0	2	2	5	2	4	1	2	3	1	1	2	3	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:107845853G>A	uc003hyi.2	-	3	1083	c.378C>T	c.(376-378)ATC>ATT	p.I126I	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Silent_p.I126I	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	126	DKK-type Cys-1.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CTGGGATACAGATGCCTGGAG	0.403													81	102					0	0	0	0	A	107845853	A	A	107845853	2	1	3	1	0	0	0	0	0	0	0	1	4567	932	33	2		2	DKK2	4	107845853	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	528	107845853	83308423	120	500											
CASP6	839	broad.mit.edu	37	chr4	110610524	110610524	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaatgcagctttttagttaGcattgaggcaaaacagggaa	15	10	11	5	0	0	1	0	1	0	0	0	3	0	2	0	2	4	5	0	2	6	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:110610524G>C	uc003hzn.1	-	7	922	c.844C>G	c.(844-846)CTA>GTA	p.L282V	CASP6_uc003hzo.1_Missense_Mutation_p.L193V	NM_001226	NP_001217	P55212	CASP6_HUMAN	caspase 6 isoform alpha preproprotein	282					cellular component disassembly involved in apoptosis|induction of apoptosis|proteolysis	cytosol|nucleoplasm	cysteine-type endopeptidase activity|protein binding			ovary(1)|breast(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000171)		TTTTTAGTTAGCATTGAGGCA	0.368													85	114					0	0	0	0	C	110610524	C	C	110610524	3	2	3	1	0	0	0	0	1	0	0	0	2687	962	34	4	41	4	CASP6	4	110610524	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	2764671	110610524	80543752	121	501											
ENPEP	2028	broad.mit.edu	37	chr4	111431455	111431455	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagacttgtggctaaatgaaGgatttgcttctttctttgag	10	16	10	5	0	2	3	0	2	2	1	2	4	2	4	0	2	1	2	0	2	4	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:111431455G>T	uc003iab.3	+	6	1591	c.1249G>T	c.(1249-1251)GGA>TGA	p.G417*		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	417	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GCTAAATGAAGGATTTGCTTC	0.373													54	80					1.1362e-29	1.49449e-29	1	0	T	111431455	T	T	111431455	4	4	3	1	0	0	0	0	0	1	0	0	5152	1001	35	4	1271	4	ENPEP	4	111431455	Nonsense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	820931	111431455	79722821	122	502											
ANK2	287	broad.mit.edu	37	chr4	114277866	114277866	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctccttctccacttccatcaAgcatggactccaattccagt	9	12	4	16	0	2	0	1	0	1	0	7	1	6	1	5	1	1	1	5	1	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:114277866A>T	uc003ibe.3	+	38	8192	c.8092A>T	c.(8092-8094)AGC>TGC	p.S2698C	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Translation_Start_Site|ANK2_uc011cgb.1_Missense_Mutation_p.S2713C	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2665					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACTTCCATCAAGCATGGACTC	0.443													60	91					0	0	0	0	T	114277866	T	T	114277866	3	4	3	1	0	0	0	0	1	0	0	0	621	72	3	5	8307	5	ANK2	4	114277866	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	2846411	114277866	76876410	123	503											
C4orf3	401152	broad.mit.edu	37	chr4	120221511	120221511	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catggcaaaaaatacacaaaGagaaacaccaccacatcgaa	22	3	5	11	1	0	1	0	0	0	1	1	3	0	1	2	1	2	1	2	1	7	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:120221511G>C	uc003icv.3	-	1	458	c.180C>G	c.(178-180)CTC>CTG	p.L60L		NM_001001701	NP_001001701	Q8WVX3	CD003_HUMAN	hypothetical protein LOC401152	60	Helical; (Potential).					integral to membrane					0						AATACACAAAGAGAAACACCA	0.328													75	64					0	0	0	0	C	120221511	C	C	120221511	2	2	3	1	0	0	0	0	0	0	0	1	2270	929	33	2		2	C4orf3	4	120221511	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	5943645	120221511	70932765	124	504											
PCDH10	57575	broad.mit.edu	37	chr4	134076163	134076163	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatcatgatgccaccaacCgtgcccagtcagctggtaag	10	8	11	12	1	2	2	2	2	0	0	2	2	2	2	4	1	4	2	4	1	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:134076163C>A	uc003iha.2	+	3	3608	c.2782C>A	c.(2782-2784)CGT>AGT	p.R928S		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	928	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TGCCACCAACCGTGCCCAGTC	0.423													28	45					5.45727e-16	6.36452e-16	1	0	A	134076163	A	A	134076163	3	1	3	1	0	0	0	0	1	0	0	0	11561	652	23	3	2852	3	PCDH10	4	134076163	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	13854652	134076163	57078113	125	505											
DCHS2	54798	broad.mit.edu	37	chr4	155241774	155241774	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccggtctgtcacattcacagCctgatcagatgctgttactg	8	12	9	12	1	4	2	3	1	1	1	4	2	4	2	2	1	3	2	2	1	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:155241774C>A	uc003inw.2	-	14	3412	c.3412G>T	c.(3412-3414)GCT>TCT	p.A1138S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1138	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ACATTCACAGCCTGATCAGAT	0.458													100	139					9.45097e-43	1.35474e-42	1	0	A	155241774	A	A	155241774	3	1	3	1	0	0	0	0	1	0	0	0	4305	739	26	4	5386	4	DCHS2	4	155241774	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	21165611	155241774	35912502	126	506											
NPY5R	4889	broad.mit.edu	37	chr4	164272139	164272139	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaagtgtctgcagaagtatAagctgtggattgtccaacaa	14	10	10	7	0	1	1	0	0	1	1	2	2	2	2	1	1	3	3	1	1	6	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:164272139A>G	uc003iqn.2	+	4	896	c.714A>G	c.(712-714)ATA>ATG	p.I238M		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	238	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				GCAGAAGTATAAGCTGTGGAT	0.368													58	90					0	0	0	0	G	164272139	G	G	164272139	3	3	3	1	0	0	0	0	1	0	0	0	10664	352	13	5	716	5	NPY5R	4	164272139	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	9030365	164272139	26882137	127	507											
GALNTL6	442117	broad.mit.edu	37	chr4	172735864	172735864	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtcagcggagcccggggagCagcaggtaagtgccacccag	10	3	16	12	2	1	0	1	0	0	0	1	2	1	2	3	4	5	3	3	4	1	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:172735864C>G	uc003isv.2	+	2	869	c.133C>G	c.(133-135)CAG>GAG	p.Q45E		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	45	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GCCCGGGGAGCAGCAGGTAAG	0.547													17	48					0	0	0	0	G	172735864	G	G	172735864	3	3	3	1	0	0	0	0	1	0	0	0	6260	711	25	4	135	4	GALNTL6	4	172735864	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	8463725	172735864	18418412	128	508											
GALNTL6	442117	broad.mit.edu	37	chr4	173150916	173150916	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaaagaggctatgcgctcagGtatgaagctcagtgtacgcc	11	8	13	9	2	2	2	2	1	0	1	2	3	2	2	1	2	3	5	1	2	5	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr4:173150916G>T	uc003isv.2	+	3	983	c.247_splice	c.e3+1	p.G83_splice		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6							Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						ATGCGCTCAGGTATGAAGCTC	0.448													16	17					4.7546e-09	5.10761e-09	1	0	T	173150916	T	T	173150916	5	4	3	1	0	0	0	0	0	0	1	0	6260	1275	44	4	254	4	GALNTL6	4	173150916	Splice_Site	SNP	G	TCGA-BA-4076-01A-01D-1434-08	415052	173150916	18003360	129	509											
DNAH5	1767	broad.mit.edu	37	chr5	13735961	13735961	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcaaataagcccagaaactGgcgaagcgaagtctgataca	16	6	10	9	2	2	2	1	1	1	1	2	4	2	2	1	1	4	0	1	1	6	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:13735961G>A	uc003jfd.2	-	67	11578	c.11536C>T	c.(11536-11538)CAG>TAG	p.Q3846*	DNAH5_uc003jfc.2_Nonsense_Mutation_p.Q14*	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3846					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCCAGAAACTGGCGAAGCGAA	0.468									Kartagener_syndrome				65	173					0	0	0	0	A	13735961	A	A	13735961	4	1	3	1	0	0	0	0	0	1	0	0	4626	1357	47	4	2390	4	DNAH5	5	13735961	Nonsense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08		13735961	167179299	130	510											
CDH10	1008	broad.mit.edu	37	chr5	24537586	24537586	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttgatcacaaactctgaCtctggctctactggcctcag	9	13	7	12	0	5	2	2	2	3	0	5	2	5	2	1	2	2	1	1	2	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:24537586C>T	uc003jgr.1	-	3	761	c.429G>A	c.(427-429)GAG>GAA	p.E143E	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	143	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		CAAACTCTGACTCTGGCTCTA	0.418										HNSCC(23;0.051)			94	123					0	0	0	0	T	24537586	T	T	24537586	2	4	3	1	0	0	0	0	0	0	0	1	3111	564	20	4		4	CDH10	5	24537586	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	10801625	24537586	156377674	131	511											
CDH9	1007	broad.mit.edu	37	chr5	26885967	26885967	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccgagtcatgattcctgcTgtattatctgggggagaaaa	10	13	11	7	1	2	2	1	1	1	1	4	4	4	2	2	2	1	2	2	2	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:26885967T>C	uc003jgs.1	-	11	1807	c.1638A>G	c.(1636-1638)ACA>ACG	p.T546T	CDH9_uc011cnv.1_Silent_p.T139T	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	546	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TGATTCCTGCTGTATTATCTG	0.308													37	78					0	0	0	0	C	26885967	C	C	26885967	2	2	3	1	0	0	0	0	0	0	0	1	3132	1567	55	5		5	CDH9	5	26885967	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	2348381	26885967	154029293	132	512											
FYB	2533	broad.mit.edu	37	chr5	39153579	39153579	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacggaggtttaatgtttctGggaggtaggcttgggactgg	8	12	17	4	1	1	0	0	0	1	0	1	3	1	3	0	7	1	4	0	7	3	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:39153579G>C	uc003jls.2	-	2	1330	c.1263C>G	c.(1261-1263)CCC>CCG	p.P421P	FYB_uc003jlt.2_Silent_p.P421P|FYB_uc003jlu.2_Silent_p.P421P|FYB_uc011cpl.1_Silent_p.P431P	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	421	Interaction with SKAP1.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TAATGTTTCTGGGAGGTAGGC	0.488													115	184					0	0	0	0	C	39153579	C	C	39153579	2	2	3	1	0	0	0	0	0	0	0	1	6158	1335	47	4		4	FYB	5	39153579	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	12267612	39153579	141761681	133	513											
HEATR7B2	133558	broad.mit.edu	37	chr5	41048516	41048516	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcagtatcttcaaaagccCtattgcaccagccccacgta	12	8	7	14	1	2	0	1	0	1	0	2	0	2	0	4	1	3	4	4	1	5	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:41048516C>G	uc003jmj.3	-	16	2084	c.1594G>C	c.(1594-1596)GGG>CGG	p.G532R	HEATR7B2_uc003jmi.3_Missense_Mutation_p.G87R	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	532	HEAT 6.						binding			ovary(6)|central_nervous_system(2)	8						TTCAAAAGCCCTATTGCACCA	0.458													45	63					0	0	0	0	G	41048516	G	G	41048516	3	3	3	1	0	0	0	0	1	0	0	0	7074	681	24	4	3271	4	HEATR7B2	5	41048516	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1894937	41048516	139866744	134	514											
C6	729	broad.mit.edu	37	chr5	41201815	41201815	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacttatctactactatttGtctgtaaccatgaagaagaa	14	14	6	7	0	2	3	0	1	2	2	2	3	2	3	1	0	4	2	1	0	9	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:41201815G>C	uc003jmk.2	-	3	355	c.145C>G	c.(145-147)CAA>GAA	p.Q49E	C6_uc003jml.1_Missense_Mutation_p.Q49E	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	49	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ACTACTATTTGTCTGTAACCA	0.363													51	79					0	0	0	0	C	41201815	C	C	41201815	3	2	3	1	0	0	0	0	1	0	0	0	2325	1391	48	4	2723	4	C6	5	41201815	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	153299	41201815	139713445	135	515											
HCN1	348980	broad.mit.edu	37	chr5	45396681	45396681	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcatagcaggtggccccGacgatcatgctcagcatggt	9	8	13	11	2	2	0	2	0	0	0	2	2	2	0	2	4	3	4	2	4	1	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:45396681G>T	uc003jok.2	-	4	1168	c.1143C>A	c.(1141-1143)GTC>GTA	p.V381V		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	381	Helical; Name=Segment S6; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AGGTGGCCCCGACGATCATGC	0.507													43	63					1.32136e-16	1.55276e-16	1	0	T	45396681	T	T	45396681	2	4	3	1	0	0	0	0	0	0	0	1	7035	1045	37	3		3	HCN1	5	45396681	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	4194866	45396681	135518579	136	516											
RAB3C	115827	broad.mit.edu	37	chr5	58147124	58147124	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccatcactgctgcaaagcaGaacacgagactcaaggaaac	16	4	9	12	1	2	2	2	0	0	2	2	4	2	3	1	1	5	3	1	1	4	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:58147124G>A	uc003jrp.2	+	5	727	c.630G>A	c.(628-630)CAG>CAA	p.Q210Q		NM_138453	NP_612462	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	210					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)|central_nervous_system(1)	2		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		CTGCAAAGCAGAACACGAGAC	0.532													90	24					0	0	0	0	A	58147124	A	A	58147124	2	1	3	1	0	0	0	0	0	0	0	1	12998	933	33	2		2	RAB3C	5	58147124	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	12750443	58147124	122768136	137	517											
PCDHA6	56142	broad.mit.edu	37	chr5	140209242	140209242	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaggtgtacgcgctgcagccGctggaccacgaggagctaga	10	5	15	11	4	0	1	0	0	0	1	0	4	0	3	2	3	4	5	2	3	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:140209242G>T	uc003lho.2	+	1	1593	c.1566G>T	c.(1564-1566)CCG>CCT	p.P522P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.P522P|PCDHA6_uc011dab.1_Silent_p.P522P	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	522	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGCAGCCGCTGGACCACG	0.682													139	26					9.62737e-85	1.46627e-84	1	0	T	140209242	T	T	140209242	2	4	3	1	0	0	0	0	0	0	0	1	11582	1074	38	3		3	PCDHA6	5	140209242	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	82062118	140209242	40706018	138	518											
PCDHA13	56136	broad.mit.edu	37	chr5	140262387	140262387	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggatcccaacgattatttCactttggacgcacaaaacag	13	10	7	11	2	1	0	1	0	0	0	2	3	2	2	1	2	2	1	1	2	4	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:140262387C>G	uc003lif.2	+	1	534	c.534C>G	c.(532-534)TTC>TTG	p.F178L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.F178L|PCDHA13_uc003lid.2_Missense_Mutation_p.F178L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	178	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGATTATTTCACTTTGGACG	0.433													118	21					0	0	0	0	G	140262387	G	G	140262387	3	3	3	1	0	0	0	0	1	0	0	0	11577	825	29	2	536	2	PCDHA13	5	140262387	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	53145	140262387	40652873	139	519											
PCDHB6	56130	broad.mit.edu	37	chr5	140531709	140531709	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcacaatggcgaggtgcgcaCcgccaggctgctgagcgagc	8	4	16	13	4	0	1	0	1	0	0	0	3	0	1	2	3	4	4	2	3	1	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:140531709C>A	uc003lir.2	+	1	1871	c.1871C>A	c.(1870-1872)ACC>AAC	p.T624N	PCDHB6_uc011dah.1_Missense_Mutation_p.T488N	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	624	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGTGCGCACCGCCAGGCTG	0.687													55	8					5.98616e-33	8.08044e-33	1	0	A	140531709	A	A	140531709	3	1	3	1	0	0	0	0	1	0	0	0	11600	507	18	4	1873	4	PCDHB6	5	140531709	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	269322	140531709	40383551	140	520											
GABRG2	2566	broad.mit.edu	37	chr5	161524815	161524815	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactggatcaccacccccAacaggatgctgagaatttgg	12	7	9	13	0	1	1	1	1	0	1	1	4	1	3	3	3	2	1	3	3	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr5:161524815A>T	uc003lyz.3	+	4	857	c.499A>T	c.(499-501)AAC>TAC	p.N167Y	GABRG2_uc010jjc.2_Missense_Mutation_p.N167Y|GABRG2_uc003lyy.3_Missense_Mutation_p.N167Y|GABRG2_uc011dej.1_Missense_Mutation_p.N72Y	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	167	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CACCACCCCCAACAGGATGCT	0.423													136	17					0	0	0	0	T	161524815	T	T	161524815	3	4	3	1	0	0	0	0	1	0	0	0	6206	130	5	5	513	5	GABRG2	5	161524815	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	20993106	161524815	19390445	141	521											
ATXN1	6310	broad.mit.edu	37	chr6	16327496	16327496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acgggtgaggaaccgacttgCcgcctgccttgcccaggccc	6	6	13	16	3	0	1	0	1	0	0	0	3	0	2	6	3	4	0	6	3	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:16327496C>T	uc003nbt.2	-	8	2017	c.1046G>A	c.(1045-1047)GGC>GAC	p.G349D	ATXN1_uc010jpi.2_Missense_Mutation_p.G349D|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	349					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				AACCGACTTGCCGCCTGCCTT	0.677													4	146					0	0	0	0	T	16327496	T	T	16327496	3	4	3	1	0	0	0	0	1	0	0	0	1211	739	26	4	1409	4	ATXN1	6	16327496	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08		16327496	154787571	142	522											
OR14J1	442191	broad.mit.edu	37	chr6	29274690	29274690	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctgcttcatctctgtcaCagtcccccagtccattgcaa	7	12	5	17	0	4	0	2	0	2	0	7	0	6	0	4	0	2	2	4	0	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:29274690C>A	uc011dln.1	+	1	224	c.224C>A	c.(223-225)ACA>AAA	p.T75K		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	75	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCTCTGTCACAGTCCCCCAG	0.453													277	73					5.24693e-114	8.15211e-114	1	0	A	29274690	A	A	29274690	3	1	3	1	0	0	0	0	1	0	0	0	11002	478	17	4	226	4	OR14J1	6	29274690	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	12947194	29274690	141840377	143	523											
TREML2	79865	broad.mit.edu	37	chr6	41162312	41162312	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggcattgctgggagacgcGgtcactgtctgggaccccat	6	9	14	12	2	2	1	1	0	1	1	2	3	2	2	2	4	1	2	2	4	0	1	rs141822677	byFrequency	TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:41162312G>A	uc010jxm.1	-	3	815	c.636C>T	c.(634-636)ACC>ACT	p.T212T		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	212	Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGGAGACGCGGTCACTGTCT	0.627													24	33					0	0	0	0	A	41162312	A	A	41162312	2	1	3	1	0	0	0	0	0	0	0	1	16540	1103	39	1		1	TREML2	6	41162312	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	11887622	41162312	129952755	144	524											
RCAN2	10231	broad.mit.edu	37	chr6	46191030	46191030	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtccctgcatggagctcatActtctctcctgaaaagcaag	11	10	8	12	0	2	1	1	1	1	0	5	2	4	2	2	1	4	3	2	1	4	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:46191030A>G	uc003oyb.1	-	4	757	c.442T>C	c.(442-444)TAT>CAT	p.Y148H	RCAN2_uc003oyc.1_Missense_Mutation_p.Y194H|RCAN2_uc003oyd.1_Missense_Mutation_p.Y194H	NM_005822	NP_005813	Q14206	RCAN2_HUMAN	Down syndrome critical region gene 1-like 1	148					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding				0						TGGAGCTCATACTTCTCTCCT	0.502													84	113					0	0	0	0	G	46191030	G	G	46191030	3	3	3	1	0	0	0	0	1	0	0	0	13234	391	14	5	155	5	RCAN2	6	46191030	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	5028718	46191030	124924037	145	525											
GPR116	221395	broad.mit.edu	37	chr6	46856179	46856179	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgataggatccaggaaggatGcattttcaaaactgatctca	14	11	9	7	0	2	2	2	2	1	0	4	5	3	5	1	3	2	1	1	3	4	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:46856179G>T	uc003oyo.3	-	4	510	c.221C>A	c.(220-222)GCA>GAA	p.A74E	GPR116_uc003oyp.3_Missense_Mutation_p.A74E|GPR116_uc003oyq.3_Missense_Mutation_p.A74E|GPR116_uc003oyr.2_Missense_Mutation_p.A74E	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	74	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CAGGAAGGATGCATTTTCAAA	0.398													53	86					1.08114e-33	1.47226e-33	1	0	T	46856179	T	T	46856179	3	4	3	1	0	0	0	0	1	0	0	0	6671	1319	46	4	3891	4	GPR116	6	46856179	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	665149	46856179	124258888	146	526											
TFAP2D	83741	broad.mit.edu	37	chr6	50740375	50740375	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtttgatcactcatggctTtgggactccggcaatatgtg	8	13	11	9	1	2	1	2	1	0	0	3	2	3	2	1	3	0	3	1	3	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:50740375T>A	uc003paf.2	+	8	1669	c.1157T>A	c.(1156-1158)TTT>TAT	p.F386Y	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	386	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					ACTCATGGCTTTGGGACTCCG	0.403													43	53					0	0	0	0	A	50740375	A	A	50740375	3	1	3	1	0	0	0	0	1	0	0	0	15856	1841	64	5	1187	5	TFAP2D	6	50740375	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	3884196	50740375	120374692	147	527											
PKHD1	5314	broad.mit.edu	37	chr6	51897833	51897833	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatcacatattttacctgctAtattgcttatgtttctgctc	8	20	4	9	0	2	0	1	0	1	0	3	0	2	0	1	0	4	4	1	0	6	9			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:51897833A>G	uc003pah.1	-	29	3635	c.3359T>C	c.(3358-3360)ATA>ACA	p.I1120T	PKHD1_uc003pai.2_Missense_Mutation_p.I1120T	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1120	Extracellular (Potential).|IPT/TIG 6; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TTTACCTGCTATATTGCTTAT	0.363													52	76					0	0	0	0	G	51897833	G	G	51897833	3	3	3	1	0	0	0	0	1	0	0	0	12026	449	16	5	9060	5	PKHD1	6	51897833	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	1157458	51897833	119217234	148	528											
PKHD1	5314	broad.mit.edu	37	chr6	51947243	51947243	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaacaggaaagacgtcacaGggaacactccgcagtgcggg	15	3	13	10	3	1	1	1	0	0	1	2	3	2	3	1	3	3	1	1	3	4	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:51947243G>A	uc003pah.1	-	4	504	c.228C>T	c.(226-228)CCC>CCT	p.P76P	PKHD1_uc003pai.2_Silent_p.P76P	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	76	Extracellular (Potential).|IPT/TIG 1; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AGACGTCACAGGGAACACTCC	0.502													94	139					0	0	0	0	A	51947243	A	A	51947243	2	1	3	1	0	0	0	0	0	0	0	1	12026	987	35	4		4	PKHD1	6	51947243	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	49410	51947243	119167824	149	529											
ZNF451	26036	broad.mit.edu	37	chr6	57017082	57017082	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	taactacctgaacaggattgGatgcttcttccttcatcctc	9	14	6	12	0	2	1	1	1	1	0	5	3	4	3	3	2	4	1	3	2	3	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:57017082G>T	uc003pdm.1	+	12	3040	c.2816G>T	c.(2815-2817)GGA>GTA	p.G939V	ZNF451_uc003pdl.2_Missense_Mutation_p.G939V|ZNF451_uc003pdn.1_Missense_Mutation_p.G891V|uc003pdq.1_Intron	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	939					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AACAGGATTGGATGCTTCTTC	0.353													58	99					2.76378e-25	3.51547e-25	1	0	T	57017082	T	T	57017082	3	4	3	1	0	0	0	0	1	0	0	0	17989	1174	41	2	2862	2	ZNF451	6	57017082	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	5069839	57017082	114097985	150	530											
PRIM2	5558	broad.mit.edu	37	chr6	57472415	57472415	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaaagttgcagtcatacAagatctctcctggagggata	14	9	10	8	0	2	1	1	0	1	1	4	3	3	3	1	2	3	3	1	2	5	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:57472415A>T	uc003pdx.2	+	13	1291	c.1204A>T	c.(1204-1206)AAG>TAG	p.K402*		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	402					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		GCAGTCATACAAGATCTCTCC	0.433													8	75					0	0	0	0	T	57472415	T	T	57472415	4	4	3	1	0	0	0	0	0	1	0	0	12553	131	5	5	1246	5	PRIM2	6	57472415	Nonsense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	455333	57472415	113642652	151	531											
EYS	346007	broad.mit.edu	37	chr6	66205107	66205107	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttgattgcctgaagtatctAttttagtgtttacacccaaa	11	16	6	8	0	1	2	0	2	1	0	1	2	1	2	2	0	2	2	2	0	6	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:66205107A>T	uc011dxu.1	-	4	735	c.197T>A	c.(196-198)ATA>AAA	p.I66K	EYS_uc003peq.2_Missense_Mutation_p.I66K|EYS_uc003per.1_Missense_Mutation_p.I66K|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	66					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TGAAGTATCTATTTTAGTGTT	0.383													85	138					0	0	0	0	T	66205107	T	T	66205107	3	4	3	1	0	0	0	0	1	0	0	0	5357	449	16	5	9359	5	EYS	6	66205107	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	8732692	66205107	104909960	152	532											
FHL5	9457	broad.mit.edu	37	chr6	97052714	97052714	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggtggaaaagccttttgctgCcaaggatgagcgcctgctgt	8	10	14	9	1	0	1	0	1	0	0	0	3	0	3	3	3	5	2	3	3	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:97052714C>G	uc003pos.1	+	4	653	c.248C>G	c.(247-249)GCC>GGC	p.A83G	FHL5_uc003pot.1_Missense_Mutation_p.A83G	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	83	LIM zinc-binding 1.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		CCTTTTGCTGCCAAGGATGAG	0.507													63	40					0	0	0	0	G	97052714	G	G	97052714	3	3	3	1	0	0	0	0	1	0	0	0	5913	739	26	4	254	4	FHL5	6	97052714	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	30847607	97052714	74062353	153	533											
FRK	2444	broad.mit.edu	37	chr6	116381174	116381174	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcagccacgtagttagaagGaatatagccttgtagttgct	11	12	10	8	1	1	1	1	0	0	1	1	2	1	2	2	1	3	5	2	1	7	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:116381174G>A	uc003pwi.1	-	1	748	c.301C>T	c.(301-303)CCT>TCT	p.P101S		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	101	SH3.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TAGTTAGAAGGAATATAGCCT	0.468													124	54					0	0	0	0	A	116381174	A	A	116381174	3	1	3	1	0	0	0	0	1	0	0	0	6082	1174	41	2	1248	2	FRK	6	116381174	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	19328460	116381174	54733893	154	534											
ENPP3	5169	broad.mit.edu	37	chr6	132004203	132004203	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatttttcaggtaattaaaGccttacaggtagtagatcat	13	16	7	5	0	2	1	2	0	0	1	2	1	2	1	1	2	2	3	1	2	7	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:132004203G>T	uc003qcu.3	+	13	1368	c.1021G>T	c.(1021-1023)GCC>TCC	p.A341S	ENPP3_uc010kfo.1_RNA|ENPP3_uc010kfp.1_RNA|ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.A341S	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	341	Extracellular (Potential).|Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		GGTAATTAAAGCCTTACAGGT	0.378													69	32					2.05175e-36	2.86133e-36	1	0	T	132004203	T	T	132004203	3	4	3	1	0	0	0	0	1	0	0	0	5155	971	34	4	1067	4	ENPP3	6	132004203	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	15623029	132004203	39110864	155	535											
MAP3K5	4217	broad.mit.edu	37	chr6	137015389	137015389	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagcaacttgtccttcgCtttgcaccatgggaatcata	10	12	8	11	1	1	1	1	1	0	0	3	2	2	2	2	1	3	3	2	1	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:137015389C>T	uc003qhc.2	-	7	1503	c.1142G>A	c.(1141-1143)AGC>AAC	p.S381N	MAP3K5_uc011edk.1_Missense_Mutation_p.S226N|MAP3K5_uc010kgw.1_Missense_Mutation_p.S381N	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	381					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TTGTCCTTCGCTTTGCACCAT	0.388													56	253					0	0	0	0	T	137015389	T	T	137015389	3	4	3	1	0	0	0	0	1	0	0	0	9306	797	28	4	3078	4	MAP3K5	6	137015389	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5011186	137015389	34099678	156	536											
KIAA1244	57221	broad.mit.edu	37	chr6	138550985	138550985	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgccgtgctgaagatcgCggaggtgagtactgcttgtg	7	10	17	7	3	0	3	0	2	0	1	1	5	0	4	1	2	4	3	1	2	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:138550985C>A	uc003qhu.2	+	5	416	c.416C>A	c.(415-417)GCG>GAG	p.A139E		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	139					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CTGAAGATCGCGGAGGTGAGT	0.483													237	40					2.69678e-108	4.17596e-108	1	0	A	138550985	A	A	138550985	3	1	3	1	0	0	0	0	1	0	0	0	8256	768	27	3	434	3	KIAA1244	6	138550985	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1535596	138550985	32564082	157	537											
LATS1	9113	broad.mit.edu	37	chr6	149997417	149997417	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatttgtgtttctaatggTgtttgtgccaagaaaggagg	9	16	12	4	0	2	1	1	0	1	1	2	2	2	2	1	3	1	2	1	3	3	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:149997417T>A	uc003qmu.1	-	7	3410	c.2862A>T	c.(2860-2862)ACA>ACT	p.T954T	LATS1_uc010kif.1_Silent_p.T849T|LATS1_uc003qmv.1_Silent_p.T954T	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	954	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		TTTCTAATGGTGTTTGTGCCA	0.353													36	51					0	0	0	0	A	149997417	A	A	149997417	2	1	3	1	0	0	0	0	0	0	0	1	8686	1683	59	5		5	LATS1	6	149997417	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	11446432	149997417	21117650	158	538											
SYNE1	23345	broad.mit.edu	37	chr6	152464762	152464762	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggccaggatacttacgtagCctttgtagctggtgtctagc	7	13	12	9	1	1	0	0	0	1	0	1	1	1	1	2	3	5	3	2	3	5	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:152464762C>T	uc010kiw.2	-	138	25717	c.25115G>A	c.(25114-25116)GGC>GAC	p.G8372D	SYNE1_uc010kiv.2_Missense_Mutation_p.G2896D|SYNE1_uc003qos.3_Missense_Mutation_p.G2896D|SYNE1_uc003qot.3_Missense_Mutation_p.G8324D|SYNE1_uc003qou.3_Missense_Mutation_p.G8372D|SYNE1_uc003qop.3_Missense_Mutation_p.G557D|SYNE1_uc011eez.1_Missense_Mutation_p.G574D|SYNE1_uc003qoq.3_Missense_Mutation_p.G574D|SYNE1_uc003qor.3_Missense_Mutation_p.G1295D	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8372	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACTTACGTAGCCTTTGTAGCT	0.507										HNSCC(10;0.0054)			93	159					0	0	0	0	T	152464762	T	T	152464762	3	4	3	1	0	0	0	0	1	0	0	0	15511	739	26	4	1314	4	SYNE1	6	152464762	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2467345	152464762	18650305	159	539											
MYCT1	80177	broad.mit.edu	37	chr6	153043007	153043007	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctcacagtggagttcaagCaggagatctaggtcttctta	11	12	10	8	0	5	1	2	0	4	1	6	3	5	2	0	3	1	2	0	3	3	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:153043007C>G	uc003qpd.3	+	2	335	c.327C>G	c.(325-327)AGC>AGG	p.S109R	MYCT1_uc010kjc.1_Intron|MYCT1_uc003qpc.3_Missense_Mutation_p.S109R	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	109	Bipartite nuclear localization signal (Potential).					nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		GGAGTTCAAGCAGGAGATCTA	0.517													84	103					0	0	0	0	G	153043007	G	G	153043007	3	3	3	1	0	0	0	0	1	0	0	0	10075	709	25	4	333	4	MYCT1	6	153043007	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	578245	153043007	18072060	160	540											
FRMD1	79981	broad.mit.edu	37	chr6	168464322	168464322	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacgggcacgtcctccagccGgcaggcctcctggatgaagc	7	5	13	16	3	0	1	0	1	0	0	3	2	3	2	5	4	2	2	5	4	1	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr6:168464322G>T	uc003qwo.3	-	6	828	c.763C>A	c.(763-765)CGG>AGG	p.R255R	FRMD1_uc003qwm.3_Silent_p.R26R|FRMD1_uc011egs.1_Silent_p.R26R|FRMD1_uc011egt.1_Silent_p.R167R|FRMD1_uc003qwn.3_Silent_p.R187R	NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	255	FERM.					cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		TCCTCCAGCCGGCAGGCCTCC	0.667													27	56					2.48779e-11	2.72305e-11	1	0	T	168464322	T	T	168464322	2	4	3	1	0	0	0	0	0	0	0	1	6083	1115	39	3		3	FRMD1	6	168464322	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	15421315	168464322	2650745	161	541											
INTS1	26173	broad.mit.edu	37	chr7	1539130	1539130	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcacccaggtcgcccgcaaCgcggcccgcctccccctgca	5	4	10	22	5	0	0	0	0	0	0	2	0	1	0	6	2	3	3	6	2	1	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:1539130C>T	uc003skn.2	-	6	924	c.823G>A	c.(823-825)GTT>ATT	p.V275I	INTS1_uc003skq.2_Missense_Mutation_p.V275I	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	275					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		TCGCCCGCAACGCGGCCCGCC	0.682													6	23					0	0	0	0	T	1539130	T	T	1539130	3	4	3	1	0	0	0	0	1	0	0	0	7814	536	19	1	5921	1	INTS1	7	1539130	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08		1539130	157599533	162	542											
MACC1	346389	broad.mit.edu	37	chr7	20198179	20198179	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtccaatcttacctctgAggactcctacataccattct	11	12	4	14	0	3	1	0	1	3	0	5	2	5	2	4	1	3	0	4	1	5	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:20198179A>G	uc003sus.3	-	5	2114	c.1805T>C	c.(1804-1806)CTC>CCC	p.L602P	MACC1_uc010kug.2_Missense_Mutation_p.L602P	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	602	SH3.				positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						CTTACCTCTGAGGACTCCTAC	0.393													453	52					0	0	0	0	G	20198179	G	G	20198179	3	3	3	1	0	0	0	0	1	0	0	0	9194	304	11	5	765	5	MACC1	7	20198179	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	18659049	20198179	138940484	163	543											
KLHL7	55975	broad.mit.edu	37	chr7	23163426	23163426	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacgtgatcctcatggtcCaggaaagaaagatacctgct	12	9	11	9	1	1	4	1	2	0	2	3	5	3	5	3	2	2	1	3	2	3	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:23163426C>G	uc003svs.3	+	2	444	c.151C>G	c.(151-153)CAG>GAG	p.Q51E	KLHL7_uc003svr.3_Missense_Mutation_p.Q29E|KLHL7_uc011jys.1_Intron|KLHL7_uc011jyt.1_Intron|KLHL7_uc003svt.2_Missense_Mutation_p.Q3E|KLHL7_uc003svp.2_Missense_Mutation_p.Q29E|KLHL7_uc003svq.2_Missense_Mutation_p.Q51E|KLHL7_uc011jyu.1_Missense_Mutation_p.Q29E	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	51	BTB.					Golgi apparatus|nucleolus|plasma membrane					0						CCTCATGGTCCAGGAAAGAAA	0.363													105	12					0	0	0	0	G	23163426	G	G	23163426	3	3	3	1	0	0	0	0	1	0	0	0	8433	595	21	4	157	4	KLHL7	7	23163426	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2965247	23163426	135975237	164	544											
ELMO1	9844	broad.mit.edu	37	chr7	37355565	37355565	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgcagacagtggttttttCtgcaaaataacaaaaaagga	17	11	8	5	0	1	1	0	0	1	1	1	2	1	2	0	2	3	3	0	2	6	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:37355565C>T	uc003tfk.1	-	3	386	c.79_splice	c.e3-1	p.K27_splice	ELMO1_uc010kxg.1_Splice_Site_p.K27_splice	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1						actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GTGGTTTTTTCTGCAAAATAA	0.284													353	54					0	0	0	0	T	37355565	T	T	37355565	5	4	3	1	0	0	0	0	0	0	1	0	5089	927	32	2	2185	2	ELMO1	7	37355565	Splice_Site	SNP	C	TCGA-BA-4076-01A-01D-1434-08	14192139	37355565	121783098	165	545											
EPDR1	54749	broad.mit.edu	37	chr7	37960496	37960496	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gatcccggacgcctcagcgcCcccttgggcttgggcttgcc	3	8	13	17	3	1	0	1	0	0	0	2	2	2	1	5	3	2	2	5	3	0	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:37960496C>A	uc003tfp.2	+	1	334	c.315C>A	c.(313-315)GCC>GCA	p.A105A	EPDR1_uc003tfq.2_Silent_p.A105A|EPDR1_uc010kxh.2_5'Flank	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	Error:Variant_position_missing_in_Q9UM22_after_alignment					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						GCCTCAGCGCCCCCTTGGGCT	0.721													40	5					3.86002e-21	4.72801e-21	1	0	A	37960496	A	A	37960496	2	1	3	1	0	0	0	0	0	0	0	1	5187	610	22	4		4	EPDR1	7	37960496	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	604931	37960496	121178167	166	546											
CCDC132	55610	broad.mit.edu	37	chr7	92902042	92902042	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcgacttcttggaaaaacAcaggtttgttacaaaaggat	15	12	8	6	1	1	0	0	0	1	0	2	3	1	2	0	3	2	2	0	3	6	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:92902042A>G	uc003umo.2	+	11	926	c.798A>G	c.(796-798)ACA>ACG	p.T266T	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Silent_p.T236T|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Silent_p.T266T	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	266											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TTGGAAAAACACAGGTTTGTT	0.333													24	53					0	0	0	0	G	92902042	G	G	92902042	2	3	3	1	0	0	0	0	0	0	0	1	2779	146	6	5		5	CCDC132	7	92902042	Silent	SNP	A	TCGA-BA-4076-01A-01D-1434-08	54941546	92902042	66236621	167	547											
PPP1R9A	55607	broad.mit.edu	37	chr7	94740679	94740679	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacgtgtagaaaagctggaaCttttcccagtggagctagag	13	9	12	7	1	0	2	0	0	0	2	1	4	1	4	1	2	4	3	1	2	6	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:94740679C>A	uc003unp.2	+	3	1786	c.1504C>A	c.(1504-1506)CTT>ATT	p.L502I	PPP1R9A_uc010lfj.2_Missense_Mutation_p.L502I|PPP1R9A_uc011kif.1_Missense_Mutation_p.L502I|PPP1R9A_uc003unq.2_Missense_Mutation_p.L502I|PPP1R9A_uc011kig.1_Missense_Mutation_p.L502I	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	502	Interacts with protein phosphatase 1 (By similarity).					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAAGCTGGAACTTTTCCCAGT	0.388										HNSCC(28;0.073)			26	51					7.4402e-23	9.28521e-23	1	0	A	94740679	A	A	94740679	3	1	3	1	0	0	0	0	1	0	0	0	12438	565	20	4	1510	4	PPP1R9A	7	94740679	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1838637	94740679	64397984	168	548											
LAMB4	22798	broad.mit.edu	37	chr7	107669526	107669526	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcctctgtatctccagccAatttttctgccgcatctttt	5	17	6	13	1	4	0	0	0	4	0	5	0	4	0	4	1	2	2	4	1	2	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:107669526A>G	uc010ljo.1	-	33	5192	c.5108T>C	c.(5107-5109)TTG>TCG	p.L1703S	LAMB4_uc003vey.2_Missense_Mutation_p.L1703S|LAMB4_uc010ljp.1_Missense_Mutation_p.L672S	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1703	Potential.|Domain I.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						ATCTCCAGCCAATTTTTCTGC	0.363													48	21					0	0	0	0	G	107669526	G	G	107669526	3	3	3	1	0	0	0	0	1	0	0	0	8653	131	5	5	185	5	LAMB4	7	107669526	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	12928847	107669526	51469137	169	549											
FLNC	2318	broad.mit.edu	37	chr7	128478683	128478683	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcactggcgatgttgctgtgGtgatcgtggacccacagggc	6	9	16	10	2	0	1	0	1	0	0	1	3	0	2	1	4	1	3	1	4	0	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:128478683G>C	uc003vnz.3	+	8	1446	c.1237G>C	c.(1237-1239)GTG>CTG	p.V413L	FLNC_uc003voa.3_Missense_Mutation_p.V413L	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	413	Filamin 2.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TGTTGCTGTGGTGATCGTGGA	0.657													56	27					0	0	0	0	C	128478683	C	C	128478683	3	2	3	1	0	0	0	0	1	0	0	0	5967	1261	44	4	1267	4	FLNC	7	128478683	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	20809157	128478683	30659980	170	550											
AHCYL2	23382	broad.mit.edu	37	chr7	129045020	129045020	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccaaacagaaatttgacAacctctactgttgccgtgaa	14	10	6	11	1	2	3	1	2	1	1	2	3	2	3	3	0	4	1	3	0	5	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:129045020A>T	uc011kov.1	+	8	1162	c.1108A>T	c.(1108-1110)AAC>TAC	p.N370Y	AHCYL2_uc003vot.2_Missense_Mutation_p.N369Y|AHCYL2_uc003vov.2_Missense_Mutation_p.N267Y|AHCYL2_uc011kow.1_Missense_Mutation_p.N268Y|AHCYL2_uc011kox.1_Missense_Mutation_p.N267Y	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	370		NAD (By similarity).			one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						GAAATTTGACAACCTCTACTG	0.423													109	47					0	0	0	0	T	129045020	T	T	129045020	3	4	3	1	0	0	0	0	1	0	0	0	411	130	5	5	1260	5	AHCYL2	7	129045020	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	566337	129045020	30093643	171	551											
OR2F2	135948	broad.mit.edu	37	chr7	143633045	143633045	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaagaaagccttccacacGtgtgcctctcacctcacggt	11	8	8	14	2	2	2	2	0	1	2	4	2	3	2	4	1	2	0	4	1	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:143633045G>T	uc011ktv.1	+	1	720	c.720G>T	c.(718-720)ACG>ACT	p.T240T		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					CCTTCCACACGTGTGCCTCTC	0.517													46	26					1.76056e-25	2.258e-25	1	0	T	143633045	T	T	143633045	2	4	3	1	0	0	0	0	0	0	0	1	11051	1132	40	3		3	OR2F2	7	143633045	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	14588025	143633045	15505618	172	552											
CNTNAP2	26047	broad.mit.edu	37	chr7	146741062	146741062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattacagcatccgattattGcccgctatgtgcgcatagtg	10	12	9	10	3	0	0	0	0	0	0	1	1	1	0	2	0	4	3	2	0	5	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr7:146741062G>A	uc003weu.1	+	4	982	c.466G>A	c.(466-468)GCC>ACC	p.A156T		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	156	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCCGATTATTGCCCGCTATGT	0.428										HNSCC(39;0.1)			62	37					0	0	0	0	A	146741062	A	A	146741062	3	1	3	1	0	0	0	0	1	0	0	0	3662	1319	46	4	480	4	CNTNAP2	7	146741062	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	3108017	146741062	12397601	173	553											
CSMD1	64478	broad.mit.edu	37	chr8	2832134	2832134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggcagggacccctgggtgtCcacacgatatagcttcagaa	10	8	12	11	1	1	1	1	0	0	1	2	3	2	2	3	3	1	2	3	3	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:2832134C>T	uc011kwk.1	-	56	8972	c.8582G>A	c.(8581-8583)GGA>GAA	p.G2861E	CSMD1_uc011kwj.1_Missense_Mutation_p.G2190E|CSMD1_uc010lrg.2_Missense_Mutation_p.G871E	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2861	Sushi 21.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCTGGGTGTCCACACGATAT	0.498													6	20					0	0	0	0	T	2832134	T	T	2832134	3	4	3	1	0	0	0	0	1	0	0	0	3961	855	30	2	2175	2	CSMD1	8	2832134	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08		2832134	143531888	174	554											
OPRK1	4986	broad.mit.edu	37	chr8	54163409	54163409	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacactacggagtagaccgcCgtgatgatgaccgggatggc	11	6	14	10	4	0	4	0	3	0	1	0	6	0	6	3	3	2	1	3	3	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:54163409C>G	uc003xrh.1	-	1	564	c.189G>C	c.(187-189)ACG>ACC	p.T63T	OPRK1_uc003xri.1_Silent_p.T63T|OPRK1_uc010lyc.1_5'UTR	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	63	Helical; Name=1; (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	AGTAGACCGCCGTGATGATGA	0.692													27	10					0	0	0	0	G	54163409	G	G	54163409	2	3	3	1	0	0	0	0	0	0	0	1	10939	639	23	3		3	OPRK1	8	54163409	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	51331275	54163409	92200613	175	555											
JPH1	56704	broad.mit.edu	37	chr8	75227756	75227756	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagcgaggccagcgaggtaCgcagcggtgagcggatcacc	9	3	17	12	5	1	1	1	1	0	0	1	4	1	2	2	4	5	3	2	4	1	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:75227756C>G	uc003yae.2	-	2	519	c.479G>C	c.(478-480)CGT>CCT	p.R160P	JPH1_uc003yaf.2_Missense_Mutation_p.R160P|JPH1_uc003yag.1_Missense_Mutation_p.R24P	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	160	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CAGCGAGGTACGCAGCGGTGA	0.731													16	7					0	0	0	0	G	75227756	G	G	75227756	3	3	3	1	0	0	0	0	1	0	0	0	7999	536	19	3	1522	3	JPH1	8	75227756	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	21064347	75227756	71136266	176	556											
ZFHX4	79776	broad.mit.edu	37	chr8	77775753	77775753	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcttgccatactttatccCtgggtttgcttcttatttta	5	21	6	9	0	2	0	0	0	2	0	3	0	3	0	2	1	3	3	2	1	4	10			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:77775753C>G	uc003yav.2	+	11	10055	c.9668C>G	c.(9667-9669)CCT>CGT	p.P3223R		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3219						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TACTTTATCCCTGGGTTTGCT	0.493										HNSCC(33;0.089)			66	31					0	0	0	0	G	77775753	G	G	77775753	3	3	3	1	0	0	0	0	1	0	0	0	17702	681	24	4	9841	4	ZFHX4	8	77775753	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2547997	77775753	68588269	177	557											
VPS13B	157680	broad.mit.edu	37	chr8	100146859	100146859	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taatattcttatatttcttaGctcacagaaatgcaagttga	14	16	5	6	0	3	2	1	1	2	1	3	2	3	2	0	0	2	3	0	0	7	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:100146859G>T	uc003yiv.2	+	9	1318	c.1207_splice	c.e9-1	p.L403_splice	VPS13B_uc003yiw.2_Splice_Site_p.L403_splice|VPS13B_uc003yit.2_Splice_Site_p.L403_splice|VPS13B_uc003yiu.1_Splice_Site_p.L403_splice|VPS13B_uc003yix.1_5'Flank	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5						protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATATTTCTTAGCTCACAGAAA	0.279													21	44					1.96292e-10	2.12841e-10	1	0	T	100146859	T	T	100146859	5	4	3	1	0	0	0	0	0	0	1	0	17258	985	34	4	1278	4	VPS13B	8	100146859	Splice_Site	SNP	G	TCGA-BA-4076-01A-01D-1434-08	22371106	100146859	46217163	178	558											
YWHAZ	7534	broad.mit.edu	37	chr8	101936241	101936241	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctttgtatgactcttcaCttaatgtatcaagttcagca	10	17	6	8	0	5	1	3	1	2	0	5	1	5	1	0	0	1	4	0	0	4	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:101936241C>A	uc011lhe.1	-	5	797	c.620G>T	c.(619-621)AGT>ATT	p.S207I	YWHAZ_uc003yjv.2_Missense_Mutation_p.S207I|YWHAZ_uc011lhf.1_Missense_Mutation_p.S207I|YWHAZ_uc003yjw.2_Missense_Mutation_p.S207I|YWHAZ_uc010mbq.2_Missense_Mutation_p.S130I|YWHAZ_uc011lhg.1_Missense_Mutation_p.S87I|YWHAZ_uc010mbr.2_Missense_Mutation_p.S207I|YWHAZ_uc003yjx.2_Missense_Mutation_p.S207I|YWHAZ_uc003yjy.2_Missense_Mutation_p.S207I	NM_001135702	NP_001129174	P63104	1433Z_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	207					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	TGACTCTTCACTTAATGTATC	0.333													92	114					8.92586e-32	1.19441e-31	1	0	A	101936241	A	A	101936241	3	1	3	1	0	0	0	0	1	0	0	0	17574	565	20	4	125	4	YWHAZ	8	101936241	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1789382	101936241	44427781	179	559											
ENY2	56943	broad.mit.edu	37	chr8	110346585	110346585	+	5'Flank	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctagctttctgtgtgcttaGgtgcccgagctactgagggt	5	14	13	9	1	2	1	0	1	2	0	2	2	2	1	1	2	5	3	1	2	3	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:110346585G>C	uc003ynd.2	+						NUDCD1_uc003ynb.3_5'Flank|NUDCD1_uc010mcl.2_5'Flank|ENY2_uc003ync.2_5'UTR	NM_020189	NP_064574	Q9NPA8	ENY2_HUMAN	enhancer of yellow 2 homolog						histone deubiquitination|mRNA transport|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity				0	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;9.05e-13)			TGTGTGCTTAGGTGCCCGAGC	0.602													11	19					0	0	0	0	C	110346585	C	C	110346585	1	2	3	0	1	0	0	0	0	0	0	0	5170	1015	35	4		4	ENY2	8	110346585	5'Flank	SNP	G	TCGA-BA-4076-01A-01D-1434-08	8410344	110346585	36017437	180	560											
PKHD1L1	93035	broad.mit.edu	37	chr8	110468491	110468491	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agtgtgtatgttggttctagGtgtgcctgttcctgtgacct	4	17	13	7	0	1	1	0	1	1	0	2	1	2	1	3	2	1	4	3	2	2	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:110468491G>C	uc003yne.2	+	46	6979	c.6875G>C	c.(6874-6876)GGT>GCT	p.G2292A		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2292	Extracellular (Potential).|G8 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTGGTTCTAGGTGTGCCTGTT	0.373										HNSCC(38;0.096)			12	43					0	0	0	0	C	110468491	C	C	110468491	3	2	3	1	0	0	0	0	1	0	0	0	12027	1275	44	4	7057	4	PKHD1L1	8	110468491	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	121906	110468491	35895531	181	561											
PKHD1L1	93035	broad.mit.edu	37	chr8	110509268	110509268	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaggatttaccatttggaCatgctgggattatggaattt	12	14	10	5	0	0	0	0	0	0	0	0	4	0	4	1	4	2	1	1	4	4	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:110509268C>A	uc003yne.2	+	64	10552	c.10448C>A	c.(10447-10449)ACA>AAA	p.T3483K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3483	PbH1 8.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACCATTTGGACATGCTGGGAT	0.338										HNSCC(38;0.096)			56	137					4.25531e-23	5.32489e-23	1	0	A	110509268	A	A	110509268	3	1	3	1	0	0	0	0	1	0	0	0	12027	478	17	4	10702	4	PKHD1L1	8	110509268	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	40777	110509268	35854754	182	562											
MYC	4609	broad.mit.edu	37	chr8	128753024	128753024	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttgccctgcgtgaccaGatcccggagttggaaaacaa	10	11	10	10	2	0	2	0	1	0	1	1	4	1	4	3	2	3	1	3	2	3	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:128753024G>T	uc003ysi.2	+	3	1710	c.1185G>T	c.(1183-1185)CAG>CAT	p.Q395H		NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	380	Helix-loop-helix motif.				branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity	p.Q380Q(1)		lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		TGCGTGACCAGATCCCGGAGT	0.517		3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL								94	314					2.76703e-59	4.11941e-59	1	0	T	128753024	T	T	128753024	3	4	3	1	0	0	0	0	1	0	0	0	10069	933	33	2	1195	2	MYC	8	128753024	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	18243756	128753024	17610998	183	563											
BAI1	575	broad.mit.edu	37	chr8	143558514	143558514	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggtccccgtggagcgtgtGctccagcacctgcggcgagg	4	7	17	13	4	0	0	0	0	0	0	2	2	2	1	4	4	4	2	4	4	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:143558514G>A	uc003ywm.2	+	4	1280	c.1097G>A	c.(1096-1098)TGC>TAC	p.C366Y		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	366	Extracellular (Potential).|TSP type-1 2.				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TGGAGCGTGTGCTCCAGCACC	0.716													11	24					0	0	0	0	A	143558514	A	A	143558514	3	1	3	1	0	0	0	0	1	0	0	0	1300	1319	46	4	1111	4	BAI1	8	143558514	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	14805490	143558514	2805508	184	564											
FBXL6	26233	broad.mit.edu	37	chr8	145579649	145579649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacagtgcttggtgtgaccCgggtgcccctgaggttaaga	7	10	15	9	1	0	4	0	3	0	1	0	4	0	4	3	3	2	2	3	3	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr8:145579649C>T	uc003zcb.2	-	8	1476	c.1451G>A	c.(1450-1452)CGG>CAG	p.R484Q	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_Missense_Mutation_p.R211Q|FBXL6_uc003zca.2_Missense_Mutation_p.R478Q|FBXL6_uc010mfx.2_Missense_Mutation_p.R245Q|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	484	LRR 11.				proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			TGGTGTGACCCGGGTGCCCCT	0.632													10	255					0	0	0	0	T	145579649	T	T	145579649	3	4	3	1	0	0	0	0	1	0	0	0	5755	652	23	1	176	1	FBXL6	8	145579649	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2021135	145579649	784373	185	565											
FAM122A	116224	broad.mit.edu	37	chr9	71395259	71395259	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgaggcgccgagcgccaggcGgaacagcacaacgttcccga	10	2	14	15	7	0	0	0	0	0	0	1	4	1	1	3	3	4	2	3	3	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr9:71395259G>T	uc004agw.1	+	1	296	c.179G>T	c.(178-180)CGG>CTG	p.R60L	PIP5K1B_uc004agu.2_Intron|PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_Intron	NM_138333	NP_612206	Q96E09	F122A_HUMAN	hypothetical protein LOC116224	60											0						AGCGCCAGGCGGAACAGCACA	0.697													77	11					1.36236e-49	1.98982e-49	1	0	T	71395259	T	T	71395259	3	4	3	1	0	0	0	0	1	0	0	0	5447	1116	39	3	181	3	FAM122A	9	71395259	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08		71395259	69818172	186	566											
KIAA1529	57653	broad.mit.edu	37	chr9	100079416	100079416	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcaacctgatggagtccAccctgcagcaggagctggac	9	8	12	12	0	1	1	1	1	0	0	2	4	2	4	3	3	4	3	3	3	1	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr9:100079416A>C	uc011lut.1	+	21	2187	c.1414A>C	c.(1414-1416)ACC>CCC	p.T472P	KIAA1529_uc004axe.1_Missense_Mutation_p.T472P|KIAA1529_uc004axg.1_Missense_Mutation_p.T333P|KIAA1529_uc011lus.1_Missense_Mutation_p.T290P|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.T333P|KIAA1529_uc011luv.1_Missense_Mutation_p.T330P	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				GATGGAGTCCACCCTGCAGCA	0.602													10	124					0	0	0	0	C	100079416	C	C	100079416	3	2	3	1	0	0	0	0	1	0	0	0	8279	159	6	5	1460	5	KIAA1529	9	100079416	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	28684157	100079416	41134015	187	567											
RNF20	56254	broad.mit.edu	37	chr9	104319794	104319794	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatttcaagctcatgtcagaGcgtatcaagtccaatcagat	14	11	7	9	1	5	2	5	0	0	2	6	2	6	2	1	0	2	2	1	0	5	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr9:104319794G>A	uc004bbn.2	+	16	2388	c.2298G>A	c.(2296-2298)GAG>GAA	p.E766E		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	766	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		TCATGTCAGAGCGTATCAAGT	0.453													77	13					0	0	0	0	A	104319794	A	A	104319794	2	1	3	1	0	0	0	0	0	0	0	1	13538	962	34	4		4	RNF20	9	104319794	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	4240378	104319794	36893637	188	568											
SLC44A1	23446	broad.mit.edu	37	chr9	108136948	108136948	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaggatgcctttgtcattCtggtggagaatgctttgcga	9	13	12	7	1	2	1	1	0	1	1	2	4	2	2	1	3	3	1	1	3	2	3	rs71801338		TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr9:108136948C>G	uc004bcn.2	+	13	1785	c.1564C>G	c.(1564-1566)CTG>GTG	p.L522V	SLC44A1_uc010mtk.1_Missense_Mutation_p.L522V|SLC44A1_uc004bco.1_Missense_Mutation_p.L314V	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	522	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	CTTTGTCATTCTGGTGGAGAA	0.418													100	135					0	0	0	0	G	108136948	G	G	108136948	3	3	3	1	0	0	0	0	1	0	0	0	14699	912	32	2	1614	2	SLC44A1	9	108136948	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	3817154	108136948	33076483	189	569											
FKBP15	23307	broad.mit.edu	37	chr9	115983487	115983487	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacccgccgctcggcgagaGgaaatcggtgtcgtcctcgt	6	8	13	14	7	1	1	1	0	0	1	6	3	2	2	3	3	0	1	3	3	1	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr9:115983487G>A	uc004bgs.2	-	1	155	c.37C>T	c.(37-39)CTC>TTC	p.L13F	FKBP15_uc010muu.1_Missense_Mutation_p.L77F|SLC31A1_uc004bgu.2_5'Flank|SLC31A1_uc004bgv.3_5'Flank|FKBP15_uc011lxd.1_5'UTR|FKBP15_uc010mut.1_5'UTR|FKBP15_uc004bgt.2_Missense_Mutation_p.L13F	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	13					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						CTCGGCGAGAGGAAATCGGTG	0.627													25	5					0	0	0	0	A	115983487	A	A	115983487	3	1	3	1	0	0	0	0	1	0	0	0	5937	1000	35	4	3734	4	FKBP15	9	115983487	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	7846539	115983487	25229944	190	570											
OR1J2	26740	broad.mit.edu	37	chr9	125273992	125273992	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaggcccttgggaaactCttcagtagagcaacattttt	13	11	9	8	0	2	2	1	0	1	2	2	3	2	3	1	2	3	2	1	2	4	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr9:125273992C>A	uc004bmj.1	+	4	1767	c.912C>A	c.(910-912)CTC>CTA	p.L304L	OR1J2_uc011lyv.1_Silent_p.L304L	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|pancreas(1)|breast(1)	5						TTGGGAAACTCTTCAGTAGAG	0.383													93	21					3.59392e-34	4.95234e-34	1	0	A	125273992	A	A	125273992	2	1	3	1	0	0	0	0	0	0	0	1	11014	900	32	2		2	OR1J2	9	125273992	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	9290505	125273992	15939439	191	571											
OR1L4	254973	broad.mit.edu	37	chr9	125486583	125486583	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgatccagatgtacttcttCatggcatttgggaacactga	10	13	9	9	0	2	3	1	2	1	1	3	4	3	4	1	2	2	2	1	2	2	4	rs139043736	by1000genomes	TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr9:125486583C>T	uc004bmu.1	+	1	315	c.315C>T	c.(313-315)TTC>TTT	p.F105F		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGTACTTCTTCATGGCATTTG	0.473													4	219					0	0	0	0	T	125486583	T	T	125486583	2	4	3	1	0	0	0	0	0	0	0	1	11019	825	29	2		2	OR1L4	9	125486583	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	212591	125486583	15726848	192	572											
BARHL1	56751	broad.mit.edu	37	chr9	135464656	135464656	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgtcgggttggagctgcTggcggaggcaggcaattact	6	8	18	9	3	0	0	0	0	0	0	1	2	0	2	1	7	3	5	1	7	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr9:135464656T>A	uc004cbp.1	+	3	923	c.731T>A	c.(730-732)CTG>CAG	p.L244Q		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	244						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		TTGGAGCTGCTGGCGGAGGCA	0.632													178	22					0	0	0	0	A	135464656	A	A	135464656	3	1	3	1	0	0	0	0	1	0	0	0	1315	1580	55	5	741	5	BARHL1	9	135464656	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	9978073	135464656	5748775	193	573											
DBH	1621	broad.mit.edu	37	chr9	136505046	136505046	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctgcaggtgcagaggaccCcagaaggcctgaccctgctt	8	7	13	13	0	0	3	0	1	0	2	0	4	0	4	4	3	4	4	4	3	1	1	rs78929918		TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr9:136505046C>A	uc004cel.2	+	2	427	c.418C>A	c.(418-420)CCA>ACA	p.P140T		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	140	DOMON.|Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	GCAGAGGACCCCAGAAGGCCT	0.617													26	8					4.87955e-14	5.53734e-14	1	0	A	136505046	A	A	136505046	3	1	3	1	0	0	0	0	1	0	0	0	4267	623	22	4	424	4	DBH	9	136505046	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1040390	136505046	4708385	194	574											
NOTCH1	4851	broad.mit.edu	37	chr9	139412204	139412204	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggccccggccgacgcacCgggcatgcagatgcactgga	7	4	14	16	4	0	1	0	0	0	1	0	3	0	2	5	4	2	4	5	4	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr9:139412204C>A	uc004chz.2	-	8	1441	c.1441G>T	c.(1441-1443)GGC>TGC	p.G481C		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	481	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCCGACGCACCGGGCATGCAG	0.667			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			48	14					1.07234e-20	1.31001e-20	1	0	A	139412204	A	A	139412204	3	1	3	1	0	0	0	0	1	0	0	0	10601	666	23	3	6334	3	NOTCH1	9	139412204	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2907158	139412204	1801227	195	575											
SLC39A12	221074	broad.mit.edu	37	chr10	18254530	18254530	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtccctccagggtgtttGtctgggacaaggaaacttgc	7	13	12	9	0	1	0	0	0	1	0	3	2	3	2	2	3	2	1	2	3	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:18254530G>T	uc001ipo.2	+	4	935	c.662G>T	c.(661-663)TGT>TTT	p.C221F	SLC39A12_uc001ipn.2_Missense_Mutation_p.C221F|SLC39A12_uc001ipp.2_Missense_Mutation_p.C221F|SLC39A12_uc010qck.1_Missense_Mutation_p.C87F	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	221	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						CAGGGTGTTTGTCTGGGACAA	0.443													48	51					2.0833e-19	2.49888e-19	1	0	T	18254530	T	T	18254530	3	4	3	1	0	0	0	0	1	0	0	0	14679	1377	48	4	672	4	SLC39A12	10	18254530	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08		18254530	117280217	196	576											
PTF1A	256297	broad.mit.edu	37	chr10	23482812	23482812	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcaacaacatagaaaacgaaCcaccatttgagtttgtgtcc	15	10	6	10	1	1	2	1	1	0	1	2	3	2	2	3	0	4	1	3	0	6	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:23482812C>A	uc001irp.2	+	2	964	c.964C>A	c.(964-966)CCA>ACA	p.P322T		NM_178161	NP_835455	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	322					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				pancreas(1)|skin(1)	2						AGAAAACGAACCACCATTTGA	0.398													57	113					9.16383e-17	1.07961e-16	1	0	A	23482812	A	A	23482812	3	1	3	1	0	0	0	0	1	0	0	0	12802	507	18	4	970	4	PTF1A	10	23482812	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5228282	23482812	112051935	197	577											
KIAA1217	56243	broad.mit.edu	37	chr10	24802317	24802317	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtcctagtggagcaagagAgacaaaaatatcttcatgag	15	8	11	7	1	2	3	1	1	1	2	3	5	3	4	1	1	1	1	1	1	5	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:24802317A>T	uc001iru.3	+	10	2534	c.2131A>T	c.(2131-2133)AGA>TGA	p.R711*	KIAA1217_uc001irs.2_Nonsense_Mutation_p.R631*|KIAA1217_uc001irt.3_Nonsense_Mutation_p.R676*|KIAA1217_uc010qcy.1_Nonsense_Mutation_p.R676*|KIAA1217_uc010qcz.1_Nonsense_Mutation_p.R676*|KIAA1217_uc001irv.1_Nonsense_Mutation_p.R526*|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Nonsense_Mutation_p.R394*|KIAA1217_uc001irz.2_Nonsense_Mutation_p.R394*|KIAA1217_uc001irx.2_Nonsense_Mutation_p.R394*|KIAA1217_uc001iry.2_Nonsense_Mutation_p.R394*	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	711					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GGAGCAAGAGAGACAAAAATA	0.473											OREG0020076	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	53					0	0	0	0	T	24802317	T	T	24802317	4	4	3	1	0	0	0	0	0	1	0	0	8255	296	11	5	2169	5	KIAA1217	10	24802317	Nonsense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	1319505	24802317	110732430	198	578											
GPR158	57512	broad.mit.edu	37	chr10	25883321	25883322	+	Missense_Mutation	DNP	CC	AA	AA																															ccattgggttgcttttgattCcaaaggtattcttctaatat																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:25883321_25883322CC>AA	uc001isj.2	+	9	2053_2054	c.1993_1994CC>AA	c.(1993-1995)CCA>AAA	p.P665K	GPR158_uc001isk.2_Missense_Mutation_p.P40K	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	665	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GCTTTTGATTCCAAAGGTATTC	0.337													44	98					0	0	0	0	AA	25883322	AA	AA	25883321	3	1	3	1	0	0	0	0	1	0	0	0	6701	855	30	2	2027	2	GPR158	10	25883321	Missense_Mutation	DNP	CC	TCGA-BA-4076-01A-01D-1434-08	1081004	25883321	109651426	199	579											
ARMC4	55130	broad.mit.edu	37	chr10	28284017	28284017	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggtgatttcgaggattcCagttccatgtccggcagcag	8	10	14	9	2	0	1	0	1	0	0	4	3	3	2	3	4	1	3	3	4	0	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:28284017C>A	uc009xky.2	-	2	153	c.55G>T	c.(55-57)GGA>TGA	p.G19*	ARMC4_uc001itz.2_Nonsense_Mutation_p.G19*	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	19							binding			ovary(4)|skin(2)	6						TCGAGGATTCCAGTTCCATGT	0.453													33	48					1.45844e-13	1.65099e-13	1	0	A	28284017	A	A	28284017	4	1	3	1	0	0	0	0	0	1	0	0	955	603	21	4	3155	4	ARMC4	10	28284017	Nonsense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2400696	28284017	107250730	200	580											
HNRNPF	3185	broad.mit.edu	37	chr10	43882406	43882406	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcacagggttgagaggagaGaagaagttgtaaatgtcgtt	13	10	14	4	1	1	3	1	1	0	3	2	6	1	4	0	2	0	4	0	2	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:43882406G>A	uc009xmh.1	-	3	1414	c.927C>T	c.(925-927)TTC>TTT	p.F309F	HNRNPF_uc001jar.2_Silent_p.F309F|HNRNPF_uc001jas.2_Silent_p.F309F|HNRNPF_uc001jat.2_Silent_p.F309F|HNRNPF_uc001jav.2_Silent_p.F309F|HNRNPF_uc001jau.2_Silent_p.F309F|uc010qfa.1_Missense_Mutation_p.E30K	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	309	RRM 3.				regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0						TGAGAGGAGAGAAGAAGTTGT	0.522													55	69					0	0	0	0	A	43882406	A	A	43882406	2	1	3	1	0	0	0	0	0	0	0	1	7304	933	33	2		2	HNRNPF	10	43882406	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	15598389	43882406	91652341	201	581											
ALOX5	240	broad.mit.edu	37	chr10	45941034	45941034	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcccgattccgcaagaacCtcgaggccattgtcagcgtg	8	8	12	13	4	1	1	1	0	0	1	3	3	2	1	4	2	2	1	4	2	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:45941034C>A	uc001jce.2	+	14	2023	c.1924C>A	c.(1924-1926)CTC>ATC	p.L642I	ALOX5_uc009xmt.2_Missense_Mutation_p.L610I|ALOX5_uc010qfg.1_Missense_Mutation_p.L585I	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	642	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CCGCAAGAACCTCGAGGCCAT	0.542													47	83					2.43468e-25	3.10539e-25	1	0	A	45941034	A	A	45941034	3	1	3	1	0	0	0	0	1	0	0	0	540	681	24	4	1978	4	ALOX5	10	45941034	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2058628	45941034	89593713	202	582											
PCDH15	65217	broad.mit.edu	37	chr10	56106124	56106124	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgcaaataggtatttacataCcggatcatctggattatact	13	14	7	7	1	2	0	1	0	1	0	2	2	2	2	1	3	4	2	1	3	7	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:56106124C>A	uc001jju.1	-	6	989	c.594_splice	c.e6+1	p.P198_splice	PCDH15_uc010qhq.1_Splice_Site_p.P203_splice|PCDH15_uc010qhr.1_Splice_Site_p.P198_splice|PCDH15_uc010qhs.1_Splice_Site_p.P203_splice|PCDH15_uc010qht.1_Splice_Site_p.P198_splice|PCDH15_uc010qhu.1_Splice_Site_p.P198_splice|PCDH15_uc001jjv.1_Splice_Site_p.P176_splice|PCDH15_uc010qhv.1_Splice_Site_p.P198_splice|PCDH15_uc010qhw.1_Splice_Site_p.P198_splice|PCDH15_uc010qhx.1_Splice_Site_p.P198_splice|PCDH15_uc010qhy.1_Splice_Site_p.P203_splice|PCDH15_uc010qhz.1_Splice_Site_p.P198_splice|PCDH15_uc010qia.1_Splice_Site_p.P176_splice|PCDH15_uc010qib.1_Splice_Site_p.P176_splice|PCDH15_uc001jjw.2_Splice_Site_p.P198_splice	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor						equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TATTTACATACCGGATCATCT	0.308										HNSCC(58;0.16)			40	59					8.16277e-20	9.84209e-20	1	0	A	56106124	A	A	56106124	5	1	3	1	0	0	0	0	0	0	1	0	11565	521	18	4	7028	4	PCDH15	10	56106124	Splice_Site	SNP	C	TCGA-BA-4076-01A-01D-1434-08	10165090	56106124	79428623	203	583											
IPMK	253430	broad.mit.edu	37	chr10	59955934	59955934	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagggaacacatgagcaaaaTctatcattcgcacttctact	14	11	6	10	1	3	1	1	1	2	0	4	2	3	2	0	1	3	2	0	1	6	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:59955934T>C	uc001jkb.2	-	6	1477	c.1154A>G	c.(1153-1155)GAT>GGT	p.D385G		NM_152230	NP_689416	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	385						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			ovary(1)	1						ATGAGCAAAATCTATCATTCG	0.363													95	143					0	0	0	0	C	59955934	C	C	59955934	3	2	3	1	0	0	0	0	1	0	0	0	7831	1435	50	5	100	5	IPMK	10	59955934	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	3849810	59955934	75578813	204	584											
LRIT1	26103	broad.mit.edu	37	chr10	85992071	85992071	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcacacagacacacgccAcatacttggtcttgggcaac	11	7	8	15	1	1	1	0	0	1	1	1	1	1	1	2	2	3	2	2	2	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:85992071A>G	uc001kcz.1	-	4	1506	c.1484T>C	c.(1483-1485)GTG>GCG	p.V495A		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	495	Fibronectin type-III.|Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						GACACACGCCACATACTTGGT	0.567													14	29					0	0	0	0	G	85992071	G	G	85992071	3	3	3	1	0	0	0	0	1	0	0	0	8997	159	6	5	391	5	LRIT1	10	85992071	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	26036137	85992071	49542676	205	585											
LRIT1	26103	broad.mit.edu	37	chr10	85992310	85992310	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcccatcagagagctctccCagggcatccatctggaagtg	9	7	11	14	1	3	1	1	0	2	1	5	3	4	2	3	2	1	2	3	2	1	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:85992310C>A	uc001kcz.1	-	4	1267	c.1245G>T	c.(1243-1245)CTG>CTT	p.L415L		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	415	Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						AGAGCTCTCCCAGGGCATCCA	0.607													48	90					4.86159e-25	6.1669e-25	1	0	A	85992310	A	A	85992310	2	1	3	1	0	0	0	0	0	0	0	1	8997	581	21	4		4	LRIT1	10	85992310	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	239	85992310	49542437	206	586											
KIF20B	9585	broad.mit.edu	37	chr10	91479299	91479299	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaatgtaaaaagagccaccAtttcatgggaaaatagtcta	18	10	7	6	0	2	1	1	0	1	1	2	2	2	2	2	1	1	1	2	1	9	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:91479299A>C	uc001kgs.1	+	13	1630	c.1558A>C	c.(1558-1560)ATT>CTT	p.I520L	KIF20B_uc001kgr.1_Missense_Mutation_p.I520L	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	520					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						AAGAGCCACCATTTCATGGGA	0.343													21	35					0	0	0	0	C	91479299	C	C	91479299	3	2	3	1	0	0	0	0	1	0	0	0	8326	217	8	5	1604	5	KIF20B	10	91479299	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	5486989	91479299	44055448	207	587											
ZNF518A	9849	broad.mit.edu	37	chr10	97918677	97918677	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaagaaaaacaagtgtcAtcaataccacaagatgtgag	20	6	9	6	0	2	3	2	1	0	2	2	4	2	4	1	1	2	0	1	1	8	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:97918677A>T	uc001klp.2	+	6	3455	c.2598A>T	c.(2596-2598)TCA>TCT	p.S866S	ZNF518A_uc001klo.1_Silent_p.S336S|ZNF518A_uc001klq.2_Silent_p.S866S|ZNF518A_uc001klr.2_Silent_p.S866S	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	866					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AACAAGTGTCATCAATACCAC	0.393													33	45					0	0	0	0	T	97918677	T	T	97918677	2	4	3	1	0	0	0	0	0	0	0	1	18029	204	8	5		5	ZNF518A	10	97918677	Silent	SNP	A	TCGA-BA-4076-01A-01D-1434-08	6439378	97918677	37616070	208	588											
SFXN2	118980	broad.mit.edu	37	chr10	104486494	104486494	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctaaacatcacggacccccGcactgtctttgtatctgagc	9	10	7	15	2	3	1	1	1	2	0	3	2	3	2	3	1	2	2	3	1	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:104486494G>T	uc001kwb.2	+	2	267	c.101G>T	c.(100-102)CGC>CTC	p.R34L	SFXN2_uc001kwc.2_RNA|SFXN2_uc001kwd.2_RNA	NM_178858	NP_849189	Q96NB2	SFXN2_HUMAN	sideroflexin 2	34					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity				0		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)		ACGGACCCCCGCACTGTCTTT	0.587													47	87					1.19451e-25	1.54486e-25	1	0	T	104486494	T	T	104486494	3	4	3	1	0	0	0	0	1	0	0	0	14260	1087	38	3	103	3	SFXN2	10	104486494	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	6567817	104486494	31048253	209	589											
ATRNL1	26033	broad.mit.edu	37	chr10	117075091	117075091	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acagcctggatgtggctggtGcaatgatcctagtaatacag	11	10	12	8	0	0	1	0	1	0	0	1	2	1	2	2	3	3	3	2	3	4	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:117075091G>T	uc001lcg.2	+	18	3268	c.2882G>T	c.(2881-2883)TGC>TTC	p.C961F	ATRNL1_uc010qsm.1_Missense_Mutation_p.C136F|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	961	PSI 5.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TGTGGCTGGTGCAATGATCCT	0.443													30	70					1.26612e-14	1.45102e-14	1	0	T	117075091	T	T	117075091	3	4	3	1	0	0	0	0	1	0	0	0	1209	1319	46	4	2952	4	ATRNL1	10	117075091	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	12588597	117075091	18459656	210	590											
PDZD8	118987	broad.mit.edu	37	chr10	119044034	119044034	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcatcctaaagccacatctTcaagttttaaactaacatgc	14	11	5	11	0	2	0	1	0	1	0	3	0	3	0	2	1	4	2	2	1	6	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:119044034T>C	uc001lde.1	-	5	2409	c.2210A>G	c.(2209-2211)GAA>GGA	p.E737G		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	737					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		AGCCACATCTTCAAGTTTTAA	0.448													55	54					0	0	0	0	C	119044034	C	C	119044034	3	2	3	1	0	0	0	0	1	0	0	0	11759	1783	62	5	1258	5	PDZD8	10	119044034	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	1968943	119044034	16490713	211	591											
GPR123	84435	broad.mit.edu	37	chr10	134885501	134885501	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcgagccctcatgggcgtGggtcttcagaagtggctatt	6	10	16	9	2	3	1	2	0	1	1	3	2	3	1	1	4	1	1	1	4	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr10:134885501G>T	uc001llw.2	+	2	260	c.260G>T	c.(259-261)TGG>TTG	p.W87L				Q86SQ6	GP123_HUMAN	RecName: Full=Probable G-protein coupled receptor 123;	Error:Variant_position_missing_in_Q86SQ6_after_alignment						integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		TCATGGGCGTGGGTCTTCAGA	0.652													3	5					0.004672	0.00477513	1	0	T	134885501	T	T	134885501	3	4	3	1	0	0	0	0	1	0	0	0	6675	1363	47	4		4	GPR123	10	134885501	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	15841467	134885501	649246	212	592											
OR51L1	119682	broad.mit.edu	37	chr11	5020434	5020434	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttagcagtgaatgacctgggGatgtccctgtctacacttcc	8	12	10	11	0	1	2	0	2	1	0	3	3	3	3	3	2	2	1	3	2	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:5020434G>C	uc010qyu.1	+	1	222	c.222G>C	c.(220-222)GGG>GGC	p.G74G		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGACCTGGGGATGTCCCTGT	0.458													96	169					0	0	0	0	C	5020434	C	C	5020434	2	2	3	1	0	0	0	0	0	0	0	1	11156	1161	41	2		2	OR51L1	11	5020434	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08		5020434	129986082	213	593											
OR52N5	390075	broad.mit.edu	37	chr11	5799430	5799430	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggcaatgatagggttggtGagtgtggtagcataacgcaa	11	11	15	4	1	0	2	0	2	0	0	0	2	0	2	0	4	2	5	0	4	5	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:5799430G>C	uc010qzn.1	-	1	435	c.435C>G	c.(433-435)CTC>CTG	p.L145L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	145	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		TAGGGTTGGTGAGTGTGGTAG	0.507													61	66					0	0	0	0	C	5799430	C	C	5799430	2	2	3	1	0	0	0	0	0	0	0	1	11184	1277	45	2		2	OR52N5	11	5799430	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	778996	5799430	129207086	214	594											
NLRP14	338323	broad.mit.edu	37	chr11	7079072	7079072	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaaagtgttatctagagaGactgtcgtgagtgtttctgt	9	15	11	6	1	2	3	0	1	2	2	4	4	3	3	1	0	0	2	1	0	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:7079072G>C	uc001mfb.1	+	7	2779	c.2456G>C	c.(2455-2457)AGA>ACA	p.R819T		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	819	LRR 4.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TATCTAGAGAGACTGTCGTGA	0.408													46	102					0	0	0	0	C	7079072	C	C	7079072	3	2	3	1	0	0	0	0	1	0	0	0	10530	942	33	2	2478	2	NLRP14	11	7079072	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	1279642	7079072	127927444	215	595											
RPS13	6207	broad.mit.edu	37	chr11	17095985	17095985	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtacacagacaaatttatgCgaccagggcagaggctgtag	14	7	12	8	1	0	2	0	0	0	2	0	3	0	2	1	2	2	4	1	2	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:17095985C>G	uc001mmp.2	-	6	483	c.451G>C	c.(451-453)GCA>CCA	p.A151P		NM_001017	NP_001008	P62277	RS13_HUMAN	ribosomal protein S13	151					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA binding|protein binding|structural constituent of ribosome				0						CAAATTTATGCGACCAGGGCA	0.318													17	37					0	0	0	0	G	17095985	G	G	17095985	3	3	3	1	0	0	0	0	1	0	0	0	13688	768	27	3	8	3	RPS13	11	17095985	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	10016913	17095985	117910531	216	596											
SLC17A6	57084	broad.mit.edu	37	chr11	22363186	22363186	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgactgcacgtgcttcggcCtgccccgccgctacattatc	5	9	10	17	5	0	0	0	0	0	0	2	1	0	0	4	1	4	3	4	1	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:22363186C>A	uc001mqk.2	+	2	612	c.199C>A	c.(199-201)CTG>ATG	p.L67M		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	67	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						GTGCTTCGGCCTGCCCCGCCG	0.627													19	21					2.89027e-11	3.15612e-11	1	0	A	22363186	A	A	22363186	3	1	3	1	0	0	0	0	1	0	0	0	14486	680	24	4	205	4	SLC17A6	11	22363186	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5267201	22363186	112643330	217	597											
BDNF	627	broad.mit.edu	37	chr11	27679873	27679873	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtccttattgttttcttcaTtgggccgaactttctggtcc	4	18	8	11	2	3	0	1	0	2	0	5	1	5	0	3	2	1	1	3	2	2	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:27679873T>C	uc010rdu.1	-	2	1090	c.239A>G	c.(238-240)AAT>AGT	p.N80S	BDNFOS_uc001mrm.2_RNA|BDNFOS_uc009yij.2_RNA|BDNFOS_uc009yik.2_RNA|BDNFOS_uc009yil.2_RNA|BDNFOS_uc001mrp.2_RNA|BDNFOS_uc009yim.2_RNA|BDNFOS_uc009yin.2_RNA|BDNFOS_uc009yio.2_RNA|BDNFOS_uc009yip.2_RNA|BDNFOS_uc001mrn.2_RNA|BDNFOS_uc009yiq.2_RNA|BDNFOS_uc001mro.2_RNA|BDNFOS_uc009yir.2_RNA|BDNFOS_uc009yis.2_Intron|BDNFOS_uc009yit.2_RNA|BDNFOS_uc009yiu.2_RNA|BDNFOS_uc009yiv.2_RNA|BDNFOS_uc009yiw.2_RNA|BDNFOS_uc009yix.2_RNA|BDNFOS_uc009yiy.2_RNA|BDNFOS_uc009yiz.2_RNA|BDNFOS_uc001mrq.3_RNA|BDNFOS_uc001mrr.3_RNA|BDNFOS_uc009yja.2_RNA|BDNFOS_uc009yjb.2_RNA|BDNF_uc010rdv.1_Missense_Mutation_p.N80S|BDNF_uc001mrt.2_Missense_Mutation_p.N95S|BDNF_uc010rdw.1_Missense_Mutation_p.N80S|BDNF_uc009yjd.2_Missense_Mutation_p.N80S|BDNF_uc001mru.2_Missense_Mutation_p.N80S|BDNF_uc010rdx.1_Missense_Mutation_p.N80S|BDNF_uc010rdy.1_Missense_Mutation_p.N80S|BDNF_uc009yjg.2_Missense_Mutation_p.N80S|BDNF_uc009yje.2_Missense_Mutation_p.N162S|BDNF_uc009yjf.2_Missense_Mutation_p.N109S|BDNF_uc001mrv.2_Missense_Mutation_p.N80S|BDNF_uc001mrw.3_Missense_Mutation_p.N80S|BDNF_uc001mrx.2_Missense_Mutation_p.N80S|BDNF_uc001mry.3_Missense_Mutation_p.N80S|BDNF_uc001mrz.3_Missense_Mutation_p.N80S|BDNF_uc001msa.2_Missense_Mutation_p.N88S	NM_001143816	NP_001137288	P23560	BDNF_HUMAN	brain-derived neurotrophic factor isoform a	80						extracellular region	growth factor activity				0						GTTTTCTTCATTGGGCCGAAC	0.493													116	149					0	0	0	0	C	27679873	C	C	27679873	3	2	3	1	0	0	0	0	1	0	0	0	1396	1493	52	5	508	5	BDNF	11	27679873	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	5316687	27679873	107326643	218	598											
HIPK3	10114	broad.mit.edu	37	chr11	33358705	33358705	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacaagatttttttgcaaaGaaacagatatgtctcattct	14	14	5	8	0	2	3	1	0	2	3	3	3	2	3	1	0	2	1	1	0	4	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:33358705G>T	uc001mul.1	+	4	1576	c.1306G>T	c.(1306-1308)GAA>TAA	p.E436*	HIPK3_uc001mum.1_Nonsense_Mutation_p.E436*|HIPK3_uc009yjv.1_Nonsense_Mutation_p.E436*|HIPK3_uc009yjw.1_RNA	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	436	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						TTTTTGCAAAGAAACAGATAT	0.313													24	30					4.26978e-12	4.71815e-12	1	0	T	33358705	T	T	33358705	4	4	3	1	0	0	0	0	0	1	0	0	7157	943	33	2	1316	2	HIPK3	11	33358705	Nonsense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	5678832	33358705	101647811	219	599											
OR4C13	283092	broad.mit.edu	37	chr11	49974253	49974253	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaagactatcttattcaaTggatgtatgactcaagtctt	14	14	6	7	0	4	2	2	1	2	1	4	3	4	3	0	1	1	1	0	1	7	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:49974253T>C	uc010rhz.1	+	1	279	c.279T>C	c.(277-279)AAT>AAC	p.N93N		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						TCTTATTCAATGGATGTATGA	0.418													121	160					0	0	0	0	C	49974253	C	C	49974253	2	2	3	1	0	0	0	0	0	0	0	1	11101	1461	51	5		5	OR4C13	11	49974253	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	16615548	49974253	85032263	220	600											
OR4A16	81327	broad.mit.edu	37	chr11	55110931	55110931	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgatagacttactctgTgataaaatcgctatttcctt	11	17	6	7	1	1	4	0	3	1	1	3	4	2	4	1	0	1	1	1	0	5	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:55110931T>A	uc010rie.1	+	1	255	c.255T>A	c.(253-255)TGT>TGA	p.C85*		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						ACTTACTCTGTGATAAAATCG	0.448													138	213					0	0	0	0	A	55110931	A	A	55110931	4	1	3	1	0	0	0	0	0	1	0	0	11095	1702	59	5	257	5	OR4A16	11	55110931	Nonsense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	5136678	55110931	79895585	221	601											
OR4A15	81328	broad.mit.edu	37	chr11	55135423	55135423	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtttgtaggctccgacacCtgagtccaacaccttcagaa	10	11	8	12	1	1	2	1	1	0	1	3	3	3	2	4	1	1	3	4	1	3	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:55135423C>G	uc010rif.1	+	1	64	c.64C>G	c.(64-66)CTG>GTG	p.L22V		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GCTCCGACACCTGAGTCCAAC	0.413													22	53					0	0	0	0	G	55135423	G	G	55135423	3	3	3	1	0	0	0	0	1	0	0	0	11094	680	24	4	66	4	OR4A15	11	55135423	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	24492	55135423	79871093	222	602											
OR5D18	219438	broad.mit.edu	37	chr11	55587238	55587238	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcactgtgctagggaatattGggttgattgtgatcatcaaa	11	14	11	5	0	3	2	3	2	0	0	3	3	3	3	0	2	1	2	0	2	4	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:55587238G>T	uc010rin.1	+	1	133	c.133G>T	c.(133-135)GGG>TGG	p.G45W		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				AGGGAATATTGGGTTGATTGT	0.458													123	144					1.05862e-61	1.58621e-61	1	0	T	55587238	T	T	55587238	3	4	3	1	0	0	0	0	1	0	0	0	11211	1348	47	4	135	4	OR5D18	11	55587238	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	451815	55587238	79419278	223	603											
OR5D16	390144	broad.mit.edu	37	chr11	55606809	55606809	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcactctcttaccctgactcTtatctcagccagttgcttct	6	16	4	15	0	5	1	2	1	4	0	7	1	5	1	2	0	3	2	2	0	2	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:55606809T>A	uc010rio.1	+	1	582	c.582T>A	c.(580-582)TCT>TCA	p.S194S		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				ACCCTGACTCTTATCTCAGCC	0.393													68	117					0	0	0	0	A	55606809	A	A	55606809	2	1	3	1	0	0	0	0	0	0	0	1	11210	1596	56	5		5	OR5D16	11	55606809	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	19571	55606809	79399707	224	604											
OR5I1	10798	broad.mit.edu	37	chr11	55703661	55703661	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgtctgagaaatagcaaagGtctacaaatgataggttgct	15	11	10	5	0	2	2	0	2	2	1	2	3	2	2	0	2	3	3	0	2	6	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:55703661G>T	uc010ris.1	-	1	216	c.216C>A	c.(214-216)GAC>GAA	p.D72E		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AATAGCAAAGGTCTACAAATG	0.383													29	39					3.73988e-18	4.42856e-18	1	0	T	55703661	T	T	55703661	3	4	3	1	0	0	0	0	1	0	0	0	11218	1252	44	4	731	4	OR5I1	11	55703661	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	96852	55703661	79302855	225	605											
OR5F1	338674	broad.mit.edu	37	chr11	55761243	55761243	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctgaggctgtagatcagagGattcaacatgggaatcacca	13	8	11	9	0	3	3	3	1	0	2	3	5	3	5	2	3	1	2	2	3	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:55761243G>A	uc010riv.1	-	1	859	c.859C>T	c.(859-861)CCT>TCT	p.P287S		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					TAGATCAGAGGATTCAACATG	0.438													25	52					0	0	0	0	A	55761243	A	A	55761243	3	1	3	1	0	0	0	0	1	0	0	0	11212	1174	41	2	88	2	OR5F1	11	55761243	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	57582	55761243	79245273	226	606											
OR8K5	219453	broad.mit.edu	37	chr11	55927515	55927515	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcagcacatgcataataGgaaatagtatttcgatccac	14	11	8	8	1	0	0	0	0	0	0	2	2	1	1	1	1	3	4	1	1	5	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:55927515G>C	uc010rja.1	-	1	279	c.279C>G	c.(277-279)TCC>TCG	p.S93S		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ATGCATAATAGGAAATAGTAT	0.398													67	77					0	0	0	0	C	55927515	C	C	55927515	2	2	3	1	0	0	0	0	0	0	0	1	11299	987	35	4		4	OR8K5	11	55927515	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	166272	55927515	79079001	227	607											
OR5M9	390162	broad.mit.edu	37	chr11	56230837	56230837	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctcctgacgacaggtcagcCccaggagagtaaattctgtc	10	8	11	12	1	2	2	1	1	1	1	4	4	3	2	3	2	1	2	3	2	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:56230837C>A	uc010rjj.1	-	1	41	c.41G>T	c.(40-42)GGG>GTG	p.G14V		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					ACAGGTCAGCCCCAGGAGAGT	0.413													16	26					5.01169e-05	5.22616e-05	1	0	A	56230837	A	A	56230837	3	1	3	1	0	0	0	0	1	0	0	0	11231	623	22	4	893	4	OR5M9	11	56230837	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	303322	56230837	78775679	228	608											
OR5AP2	338675	broad.mit.edu	37	chr11	56409494	56409494	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaattctcccagacacgAgaactgggtagagcaggggg	13	5	14	9	1	1	3	0	0	1	3	2	4	1	3	1	3	3	3	1	3	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:56409494A>T	uc001njb.1	-	1	422	c.422T>A	c.(421-423)CTC>CAC	p.L141H		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						CCCAGACACGAGAACTGGGTA	0.483													25	54					0	0	0	0	T	56409494	T	T	56409494	3	4	3	1	0	0	0	0	1	0	0	0	11198	304	11	5	532	5	OR5AP2	11	56409494	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	178657	56409494	78597022	229	609											
P2RX3	5024	broad.mit.edu	37	chr11	57118349	57118349	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgtttctgagaaaagcagCgtgtccccaggctacaactt	11	9	10	11	2	1	1	0	1	1	1	2	2	2	1	2	1	5	3	2	1	4	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:57118349C>T	uc001nju.2	+	8	895	c.819C>T	c.(817-819)AGC>AGT	p.S273S		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	273	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						AGAAAAGCAGCGTGTCCCCAG	0.542													49	68					0	0	0	0	T	57118349	T	T	57118349	2	4	3	1	0	0	0	0	0	0	0	1	11395	767	27	1		1	P2RX3	11	57118349	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	708855	57118349	77888167	230	610											
SERPING1	710	broad.mit.edu	37	chr11	57379319	57379319	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggccatcatggagaaactgGagatgtccaagttccagccc	12	7	11	11	0	1	2	1	0	0	2	3	4	3	2	4	3	2	1	4	3	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:57379319G>T	uc001nkp.1	+	7	1350	c.1159G>T	c.(1159-1161)GAG>TAG	p.E387*	SERPING1_uc001nkq.1_Nonsense_Mutation_p.E350*|SERPING1_uc010rju.1_Nonsense_Mutation_p.E335*|SERPING1_uc010rjv.1_Nonsense_Mutation_p.E392*|SERPING1_uc001nkr.1_Nonsense_Mutation_p.E387*|SERPING1_uc009ymi.1_Nonsense_Mutation_p.E396*|SERPING1_uc009ymj.1_Intron|SERPING1_uc001nks.1_Nonsense_Mutation_p.E78*	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	387					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						GGAGAAACTGGAGATGTCCAA	0.502									Hereditary_Angioedema				58	104					1.72845e-40	2.44731e-40	1	0	T	57379319	T	T	57379319	4	4	3	1	0	0	0	0	0	1	0	0	14181	1175	41	2	1181	2	SERPING1	11	57379319	Nonsense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	260970	57379319	77627197	231	611											
OR1S2	219958	broad.mit.edu	37	chr11	57970930	57970930	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactttccctgtgtggatgAtactcccaggacagctctga	8	11	9	13	0	1	2	0	2	1	0	3	4	3	4	3	2	2	1	3	2	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:57970930A>G	uc010rkb.1	-	1	724	c.724T>C	c.(724-726)TCA>CCA	p.S242P		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	242	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				TGTGTGGATGATACTCCCAGG	0.453													31	67					0	0	0	0	G	57970930	G	G	57970930	3	3	3	1	0	0	0	0	1	0	0	0	11027	333	12	5	256	5	OR1S2	11	57970930	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	591611	57970930	77035586	232	612											
OR4D6	219983	broad.mit.edu	37	chr11	59224737	59224737	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgactgcatggcacagatcTttttcttccactttgctggt	7	16	8	10	0	2	2	0	1	2	1	3	2	3	2	1	2	2	3	1	2	0	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:59224737T>A	uc010rku.1	+	1	304	c.304T>A	c.(304-306)TTT>ATT	p.F102I		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGCACAGATCTTTTTCTTCCA	0.463													116	155					0	0	0	0	A	59224737	A	A	59224737	3	1	3	1	0	0	0	0	1	0	0	0	11112	1609	56	5	306	5	OR4D6	11	59224737	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	1253807	59224737	75781779	233	613											
VPS37C	55048	broad.mit.edu	37	chr11	60906239	60906239	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagggccagctggtcaatCgcctccgagtcattctgcaa	8	9	10	14	2	3	0	2	0	1	0	6	1	5	0	4	2	2	2	4	2	2	1	rs144092595	by1000genomes	TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:60906239C>A	uc001nqv.1	-	2	123	c.63G>T	c.(61-63)GCG>GCT	p.A21A	VPS37C_uc001nqw.1_Silent_p.A21A	NM_017966	NP_060436	A5D8V6	VP37C_HUMAN	vacuolar protein sorting 37C	21					cellular membrane organization|endosome transport|protein transport	late endosome membrane					0						GCTGGTCAATCGCCTCCGAGT	0.552													54	104					2.44813e-32	3.28547e-32	1	0	A	60906239	A	A	60906239	2	1	3	1	0	0	0	0	0	0	0	1	17275	871	31	3		3	VPS37C	11	60906239	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1681502	60906239	74100277	234	614											
AHNAK	79026	broad.mit.edu	37	chr11	62299641	62299641	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tttgggcattttcatcttggGcatcttcaagtgccagtctg	6	16	10	9	0	5	0	2	0	3	0	5	0	5	0	1	2	1	2	1	2	1	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:62299641G>C	uc001ntl.2	-	5	2548	c.2248C>G	c.(2248-2250)CCC>GCC	p.P750A	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	750					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTCATCTTGGGCATCTTCAAG	0.517													152	263					0	0	0	0	C	62299641	C	C	62299641	3	2	3	1	0	0	0	0	1	0	0	0	414	1203	42	4	15544	4	AHNAK	11	62299641	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	1393402	62299641	72706875	235	615											
GANAB	23193	broad.mit.edu	37	chr11	62398539	62398539	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccggaaaacatcagagatGgagggccccagcagcaggaa	14	3	14	10	1	1	1	1	0	0	1	1	5	1	4	3	4	4	2	3	4	3	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:62398539G>A	uc001nub.2	-	10	1146	c.1113C>T	c.(1111-1113)TCC>TCT	p.S371S	GANAB_uc001nua.2_Silent_p.S393S|GANAB_uc001nuc.2_Silent_p.S274S|GANAB_uc010rma.1_Silent_p.S279S|GANAB_uc010rmb.1_Silent_p.S257S	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	371					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						CATCAGAGATGGAGGGCCCCA	0.512													173	225					0	0	0	0	A	62398539	A	A	62398539	2	1	3	1	0	0	0	0	0	0	0	1	6268	1335	47	4		4	GANAB	11	62398539	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	98898	62398539	72607977	236	616											
STIP1	10963	broad.mit.edu	37	chr11	63967640	63967640	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctttgtttttcttccccaGgggactatccccaggccatg	5	14	9	13	0	2	0	0	0	2	0	4	1	4	1	5	3	0	1	5	3	1	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:63967640G>T	uc001nyk.1	+	10	1268	c.1121_splice	c.e10-1	p.G374_splice	STIP1_uc010rnb.1_Splice_Site_p.G350_splice	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1						axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3						TTCTTCCCCAGGGGACTATCC	0.498													150	203					2.45841e-106	3.79415e-106	1	0	T	63967640	T	T	63967640	5	4	3	1	0	0	0	0	0	0	1	0	15351	1014	35	4	1158	4	STIP1	11	63967640	Splice_Site	SNP	G	TCGA-BA-4076-01A-01D-1434-08	1569101	63967640	71038876	237	617											
KAT5	10524	broad.mit.edu	37	chr11	65480261	65480261	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggccgagatcctgagcgtgaAggacatcagtggccggaagc	10	5	16	10	3	1	3	1	2	0	1	2	6	2	5	3	4	2	0	3	4	2	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:65480261A>G	uc001ofi.2	+	3	354	c.104A>G	c.(103-105)AAG>AGG	p.K35R	KAT5_uc001ofj.2_Missense_Mutation_p.K35R|KAT5_uc001ofk.2_Missense_Mutation_p.K68R|KAT5_uc010roo.1_Missense_Mutation_p.K68R|KAT5_uc001ofl.2_5'UTR	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	35					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						CTGAGCGTGAAGGACATCAGT	0.562													39	78					0	0	0	0	G	65480261	G	G	65480261	3	3	3	1	0	0	0	0	1	0	0	0	8022	72	3	5	209	5	KAT5	11	65480261	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	1512621	65480261	69526255	238	618											
ADRBK1	156	broad.mit.edu	37	chr11	67049153	67049153	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgtctgcatgtcatacgcGttccacacgccagacaagct	10	10	8	13	3	2	1	1	0	1	1	3	1	3	1	2	0	3	3	2	0	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:67049153G>T	uc009yrn.1	+	10	1046	c.780G>T	c.(778-780)GCG>GCT	p.A260A	ADRBK1_uc009yrm.1_Silent_p.A260A	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	260	Protein kinase.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	TGTCATACGCGTTCCACACGC	0.672													47	64					4.17328e-34	5.73362e-34	1	0	T	67049153	T	T	67049153	2	4	3	1	0	0	0	0	0	0	0	1	343	1132	40	3		3	ADRBK1	11	67049153	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	1568892	67049153	67957363	239	619											
SHANK2	22941	broad.mit.edu	37	chr11	70333070	70333070	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccccaggcccacatcctCatcccccaggtctgtggaga	7	7	10	17	0	2	1	1	0	1	1	4	2	4	1	6	4	0	0	6	4	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:70333070C>A	uc001oqc.2	-	21	3406	c.3328G>T	c.(3328-3330)GAG>TAG	p.E1110*	SHANK2_uc010rqn.1_Nonsense_Mutation_p.E522*|SHANK2_uc001opz.2_Nonsense_Mutation_p.E515*|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	731					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCCACATCCTCATCCCCCAGG	0.692													39	654					4.0492e-12	4.49587e-12	1	0	A	70333070	A	A	70333070	4	1	3	1	0	0	0	0	0	1	0	0	14330	835	29	2	2229	2	SHANK2	11	70333070	Nonsense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	3283917	70333070	64673446	240	620											
SHANK2	22941	broad.mit.edu	37	chr11	70333674	70333674	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttggagttggggacttgggGcagttgtaagtggttgggga	6	12	20	3	0	0	0	0	0	0	0	0	3	0	3	0	8	0	5	0	8	1	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:70333674G>A	uc001oqc.2	-	21	2802	c.2724C>T	c.(2722-2724)TGC>TGT	p.C908C	SHANK2_uc010rqn.1_Silent_p.C320C|SHANK2_uc001opz.2_Silent_p.C313C|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	529	Pro-rich.				intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGGACTTGGGGCAGTTGTAAG	0.622													29	279					0	0	0	0	A	70333674	A	A	70333674	2	1	3	1	0	0	0	0	0	0	0	1	14330	1195	42	4		4	SHANK2	11	70333674	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	604	70333674	64672842	241	621											
ME3	10873	broad.mit.edu	37	chr11	86161369	86161369	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaccttggaaaacaaacaCgtgattggaaagcttgttct	13	11	9	8	1	1	1	0	1	1	0	1	3	1	3	1	2	4	3	1	2	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:86161369C>A	uc001pbz.2	-	8	1245	c.991G>T	c.(991-993)GTG>TTG	p.V331L	ME3_uc001pca.2_Missense_Mutation_p.V331L|ME3_uc009yvk.2_Missense_Mutation_p.V331L|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	331					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	AAAACAAACACGTGATTGGAA	0.502													21	13					1.96292e-10	2.12841e-10	1	0	A	86161369	A	A	86161369	3	1	3	1	0	0	0	0	1	0	0	0	9472	536	19	3	851	3	ME3	11	86161369	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	15827695	86161369	48845147	242	622											
NAALAD2	10003	broad.mit.edu	37	chr11	89892474	89892474	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaatgtgagttatagtatcGgacctggctttacagggagt	10	14	12	5	1	0	1	0	1	0	0	1	3	0	3	1	3	1	3	1	3	5	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:89892474G>T	uc001pdf.3	+	8	1067	c.958G>T	c.(958-960)GGA>TGA	p.G320*	NAALAD2_uc009yvx.2_Intron|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pdd.2_3'UTR|NAALAD2_uc001pde.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	320	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TTATAGTATCGGACCTGGCTT	0.358													51	24					7.77372e-23	9.67536e-23	1	0	T	89892474	T	T	89892474	4	4	3	1	0	0	0	0	0	1	0	0	10181	1117	39	3	988	3	NAALAD2	11	89892474	Nonsense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	3731105	89892474	45114042	243	623											
HEPHL1	341208	broad.mit.edu	37	chr11	93844770	93844770	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagccacggtgccatctaaCggtaatgataccctctcccc	9	8	7	17	2	2	1	0	1	2	0	3	1	2	1	6	2	4	1	6	2	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:93844770C>A	uc001pep.2	+	19	3433	c.3276C>A	c.(3274-3276)AAC>AAA	p.N1092K	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	1092	Extracellular (Potential).|Plastocyanin-like 6.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TGCCATCTAACGGTAATGATA	0.448													10	5					3.86212e-05	4.03648e-05	1	0	A	93844770	A	A	93844770	3	1	3	1	0	0	0	0	1	0	0	0	7094	550	19	3	3350	3	HEPHL1	11	93844770	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	3952296	93844770	41161746	244	624											
CWF19L2	143884	broad.mit.edu	37	chr11	107299911	107299911	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgccttgggttagattcTcttctacacgtttctaaaga	8	18	7	8	1	3	2	0	0	3	2	4	2	3	2	1	1	2	2	1	1	4	9			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:107299911T>A	uc010rvp.1	-	8	1077	c.1047A>T	c.(1045-1047)AGA>AGT	p.R349S	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	349							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		GGTTAGATTCTCTTCTACACG	0.348													55	27					0	0	0	0	A	107299911	A	A	107299911	3	1	3	1	0	0	0	0	1	0	0	0	4089	1548	54	5	1681	5	CWF19L2	11	107299911	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	13455141	107299911	27706605	245	625											
GRIK4	2900	broad.mit.edu	37	chr11	120690619	120690620	+	Frame_Shift_Ins	INS	-	A	A																															ccgcctgcctcatctgtgccINSaaagcagaatgtaagtttcc																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:120690619_120690620insA	uc001pxn.2	+	6	788_789	c.501_502insA	c.(499-504)GCCAAAfs	p.A167fs	GRIK4_uc009zav.1_Frame_Shift_Ins_p.A167fs|GRIK4_uc009zaw.1_Frame_Shift_Ins_p.A167fs|GRIK4_uc009zax.1_Frame_Shift_Ins_p.A167fs	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	167_168	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	TCATCTGTGCCAAAGCAGAATG	0.569													---	---	---								A	120690620	A	A	120690619	7	5	3	1	0	1	1	0	0	0	0	0	6815	581	21	0	515	0	GRIK4	11	120690619	Frame_Shift_Ins	INS	-	TCGA-BA-4076-01A-01D-1434-08	13390708	120690619	14315897	246	626											
BARX2	8538	broad.mit.edu	37	chr11	129306871	129306871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaagccccgccggagtcgcaCcatcttcaccgagctgcagc	8	5	11	17	4	2	0	1	0	1	0	3	3	2	1	5	1	4	3	5	1	1	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:129306871C>T	uc001qfc.3	+	2	463	c.413C>T	c.(412-414)ACC>ATC	p.T138I		NM_003658	NP_003649	Q9UMQ3	BARX2_HUMAN	BarH-like homeobox 2	138	Homeobox.										0	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		CGGAGTCGCACCATCTTCACC	0.627													10	6					0	0	0	0	T	129306871	T	T	129306871	3	4	3	1	0	0	0	0	1	0	0	0	1318	507	18	4	419	4	BARX2	11	129306871	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	8616252	129306871	5699645	247	627											
ADAMTS15	170689	broad.mit.edu	37	chr11	130343610	130343610	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggccggggatttcagaggcGctcactcaagtgtgtgggcc	6	8	16	11	3	3	1	3	0	0	1	3	2	3	2	2	5	0	1	2	5	1	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:130343610G>T	uc010scd.1	+	8	2747	c.2747G>T	c.(2746-2748)CGC>CTC	p.R916L		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	916	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		TTTCAGAGGCGCTCACTCAAG	0.697													38	12					2.45108e-15	2.83005e-15	1	0	T	130343610	T	T	130343610	3	4	3	1	0	0	0	0	1	0	0	0	260	1087	38	3	2777	3	ADAMTS15	11	130343610	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	1036739	130343610	4662906	248	628											
OPCML	4978	broad.mit.edu	37	chr11	132527042	132527042	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgtctgcacagagcaggTgtacggaccttcgtcataca	9	10	11	11	2	3	1	1	0	2	1	4	2	3	2	1	2	4	3	1	2	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr11:132527042T>A	uc001qgs.2	-	2	390	c.340A>T	c.(340-342)ACC>TCC	p.T114S	OPCML_uc001qgu.2_Missense_Mutation_p.T107S|OPCML_uc010sck.1_Missense_Mutation_p.T114S|OPCML_uc001qgt.2_Missense_Mutation_p.T114S|OPCML_uc010scl.1_Missense_Mutation_p.T73S	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	114	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		ACAGAGCAGGTGTACGGACCT	0.507													65	30					0	0	0	0	A	132527042	A	A	132527042	3	1	3	1	0	0	0	0	1	0	0	0	10928	1696	59	5	721	5	OPCML	11	132527042	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	2183432	132527042	2479474	249	629											
CD163	9332	broad.mit.edu	37	chr12	7636217	7636217	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccccaggaacctccatgcCagatctccacacgtccagaa	11	6	6	18	1	1	2	0	0	1	2	5	3	4	3	7	1	2	0	7	1	2	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:7636217C>G	uc001qsz.3	-	12	2962	c.2834G>C	c.(2833-2835)TGG>TCG	p.W945S	CD163_uc001qta.3_Missense_Mutation_p.W945S|CD163_uc009zfw.2_Missense_Mutation_p.W978S	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	945	SRCR 9.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						ACCTCCATGCCAGATCTCCAC	0.478													35	41					0	0	0	0	G	7636217	G	G	7636217	3	3	3	1	0	0	0	0	1	0	0	0	2982	595	21	4	656	4	CD163	12	7636217	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08		7636217	126215678	250	630											
TAS2R7	50837	broad.mit.edu	37	chr12	10954553	10954553	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatatgtctccgcagggagAggatcaagaggaaaaaggac	15	6	14	6	1	2	3	1	1	1	2	3	7	2	6	1	4	0	1	1	4	4	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:10954553A>G	uc001qyv.2	-	1	674	c.617T>C	c.(616-618)CTC>CCC	p.L206P		NM_023919	NP_076408	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	206	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						CCGCAGGGAGAGGATCAAGAG	0.498													24	32					0	0	0	0	G	10954553	G	G	10954553	3	3	3	1	0	0	0	0	1	0	0	0	15652	304	11	5	343	5	TAS2R7	12	10954553	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	3318336	10954553	122897342	251	631											
TAS2R19	259294	broad.mit.edu	37	chr12	11174609	11174609	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acatattaggctcagagtaaAgggtatgaggtttgctagag	13	11	13	4	0	1	3	1	1	0	2	1	3	1	3	0	3	1	5	0	3	6	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:11174609A>C	uc010shj.1	-	1	562	c.562T>G	c.(562-564)TTT>GTT	p.F188V	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176888	NP_795369	P59542	T2R19_HUMAN	taste receptor, type 2, member 19	188	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1						CTCAGAGTAAAGGGTATGAGG	0.393													110	153					0	0	0	0	C	11174609	C	C	11174609	3	2	3	1	0	0	0	0	1	0	0	0	15636	72	3	5	340	5	TAS2R19	12	11174609	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	220056	11174609	122677286	252	632											
PRB2	653247	broad.mit.edu	37	chr12	11546131	11546131	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaggagatcgagaacttcggGacttgctgcctccttgtggg	7	10	15	9	2	0	2	0	0	0	2	3	6	1	3	2	3	3	1	2	3	1	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:11546131G>A	uc010shk.1	-	3	916	c.881C>T	c.(880-882)TCC>TTC	p.S294F		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			AGAACTTCGGGACTTGCTGCC	0.602													20	729					0	0	0	0	A	11546131	A	A	11546131	3	1	3	1	0	0	0	0	1	0	0	0	12505	1174	41	2	373	2	PRB2	12	11546131	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	371522	11546131	122305764	253	633											
PDE3A	5139	broad.mit.edu	37	chr12	20806882	20806882	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acttgtattttatttctaggGtgatgaagaggccagccttg	9	15	11	6	0	1	3	0	2	1	1	1	3	1	3	2	2	1	1	2	2	4	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:20806882G>C	uc001reh.1	+	15	2949	c.2927G>C	c.(2926-2928)GGT>GCT	p.G976A		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	976	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TATTTCTAGGGTGATGAAGAG	0.428													45	89					0	0	0	0	C	20806882	C	C	20806882	3	2	3	1	0	0	0	0	1	0	0	0	11691	1275	44	4	2985	4	PDE3A	12	20806882	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	9260751	20806882	113045013	254	634											
MLL2	8085	broad.mit.edu	37	chr12	49433007	49433007	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aacctcctggagcctcaccgGctgttcacatccatagagga	10	8	9	14	1	2	1	2	0	0	1	4	3	4	3	5	3	2	2	5	3	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:49433007G>A	uc001rta.3	-	33	8364	c.8364C>T	c.(8362-8364)AGC>AGT	p.S2788S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2788					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGCCTCACCGGCTGTTCACAT	0.567			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			4	148					0	0	0	0	A	49433007	A	A	49433007	2	1	3	1	0	0	0	0	0	0	0	1	9674	1194	42	4		4	MLL2	12	49433007	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	28626125	49433007	84418888	255	635											
MLL2	8085	broad.mit.edu	37	chr12	49445506	49445506	+	Frame_Shift_Del	DEL	A	-	-																															tgacaccacaggcaggggggAtaggcgcgatacctcaggtg																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:49445506delA	uc001rta.3	-	10	1960	c.1960delT	c.(1960-1962)TCCfs	p.S654fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	654	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCAGGGGGGATAGGCGCGAT	0.637			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								-	49445506	-	-	49445506	7	5	3	1	0	1	0	1	0	0	0	0	9674	333	12	0	14833	0	MLL2	12	49445506	Frame_Shift_Del	DEL	A	TCGA-BA-4076-01A-01D-1434-08	12499	49445506	84406389	256	636											
GALNT6	11226	broad.mit.edu	37	chr12	51753071	51753071	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtccggaacacatggcctaCgacagagcaggggatgatct	11	6	14	10	2	1	2	0	1	1	1	2	5	2	4	2	5	3	1	2	5	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:51753071C>A	uc001ryk.2	-	7	1438	c.1213G>T	c.(1213-1215)GTA>TTA	p.V405L	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Missense_Mutation_p.V405L|GALNT6_uc001ryj.1_5'UTR	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	405	Catalytic subdomain B.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						ACATGGCCTACGACAGAGCAG	0.592													121	172					2.55716e-62	3.84404e-62	1	0	A	51753071	A	A	51753071	3	1	3	1	0	0	0	0	1	0	0	0	6252	536	19	3	675	3	GALNT6	12	51753071	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2307565	51753071	82098824	257	637											
OR6C74	254783	broad.mit.edu	37	chr12	55641868	55641868	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accctcagcaaaagaaagagTgtcattaaataaagggatag	19	7	9	6	0	2	2	2	0	0	2	2	3	2	3	1	1	1	1	1	1	8	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:55641868T>A	uc010spg.1	+	1	797	c.797T>A	c.(796-798)GTG>GAG	p.V266E		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AAAGAAAGAGTGTCATTAAAT	0.383													69	79					0	0	0	0	A	55641868	A	A	55641868	3	1	3	1	0	0	0	0	1	0	0	0	11252	1696	59	5	799	5	OR6C74	12	55641868	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	3888797	55641868	78210027	258	638											
TMEM19	55266	broad.mit.edu	37	chr12	72090220	72090220	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatatgtttctttcagggctAgtcgttggatttatcctaac	8	18	8	7	1	2	0	1	0	1	0	4	1	3	1	1	2	1	3	1	2	5	9			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:72090220A>G	uc001sws.2	+	3	832	c.249A>G	c.(247-249)CTA>CTG	p.L83L	TMEM19_uc001swr.1_Silent_p.L69L|TMEM19_uc009zru.1_RNA	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	83						integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		TTTCAGGGCTAGTCGTTGGAT	0.303													45	99					0	0	0	0	G	72090220	G	G	72090220	2	3	3	1	0	0	0	0	0	0	0	1	16179	407	15	5		5	TMEM19	12	72090220	Silent	SNP	A	TCGA-BA-4076-01A-01D-1434-08	16448352	72090220	61761675	259	639											
TBC1D15	64786	broad.mit.edu	37	chr12	72278758	72278758	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttcatcaaggagatagcAaactactgattgaatctctt	14	13	6	8	0	3	3	2	2	1	1	4	4	3	3	0	1	3	1	0	1	5	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:72278758A>G	uc001swu.2	+	5	586	c.577A>G	c.(577-579)AAA>GAA	p.K193E	TBC1D15_uc009zrv.2_Missense_Mutation_p.K72E|TBC1D15_uc010stt.1_Missense_Mutation_p.K179E|TBC1D15_uc001swv.2_Missense_Mutation_p.K193E|TBC1D15_uc001sww.2_Intron	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15 isoform 1	171							protein binding|Rab GTPase activator activity				0						AGGAGATAGCAAACTACTGAT	0.358													51	96					0	0	0	0	G	72278758	G	G	72278758	3	3	3	1	0	0	0	0	1	0	0	0	15670	131	5	5	653	5	TBC1D15	12	72278758	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	188538	72278758	61573137	260	640											
NAV3	89795	broad.mit.edu	37	chr12	78400963	78400963	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctggcagcacagcaagcAaagagtctgagaaattcagg	15	5	11	10	0	2	2	1	1	1	2	2	3	2	2	1	2	3	4	1	2	3	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:78400963A>G	uc001syp.2	+	8	1818	c.1645A>G	c.(1645-1647)AAA>GAA	p.K549E	NAV3_uc001syo.2_Missense_Mutation_p.K549E	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	549						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CACAGCAAGCAAAGAGTCTGA	0.463										HNSCC(70;0.22)			43	61					0	0	0	0	G	78400963	G	G	78400963	3	3	3	1	0	0	0	0	1	0	0	0	10238	131	5	5	1675	5	NAV3	12	78400963	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	6122205	78400963	55450932	261	641											
SLC6A15	55117	broad.mit.edu	37	chr12	85255560	85255560	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggagatggcatctcgctcgGtatttttccgtgaatgaggc	7	13	13	8	3	1	3	0	2	1	1	4	4	2	3	1	4	0	3	1	4	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:85255560G>A	uc001szv.2	-	12	2537	c.2044C>T	c.(2044-2046)CCG>TCG	p.P682S	SLC6A15_uc010sul.1_Missense_Mutation_p.P575S|SLC6A15_uc001szw.1_3'UTR	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	682	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						ATCTCGCTCGGTATTTTTCCG	0.438													90	148					0	0	0	0	A	85255560	A	A	85255560	3	1	3	1	0	0	0	0	1	0	0	0	14742	1261	44	4	152	4	SLC6A15	12	85255560	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	6854597	85255560	48596335	262	642											
LRRIQ1	84125	broad.mit.edu	37	chr12	85450746	85450746	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacctgaacctgatagcatGacctgctgtgtatcagagtc	10	10	10	11	0	1	4	1	3	0	1	2	4	1	4	3	0	3	4	3	0	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:85450746G>T	uc001tac.2	+	8	2286	c.2175G>T	c.(2173-2175)ATG>ATT	p.M725I	LRRIQ1_uc001tab.1_Missense_Mutation_p.M725I|LRRIQ1_uc001taa.1_Missense_Mutation_p.M700I	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	725										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CTGATAGCATGACCTGCTGTG	0.358													236	352					2.42195e-132	3.77563e-132	1	0	T	85450746	T	T	85450746	3	4	3	1	0	0	0	0	1	0	0	0	9079	1290	45	2	2201	2	LRRIQ1	12	85450746	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	195186	85450746	48401149	263	643											
MYO1H	283446	broad.mit.edu	37	chr12	109872840	109872840	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaacatttcttttcacttctAgaaccaaaatattcattcgt	14	16	2	9	1	4	1	2	0	2	1	5	1	4	1	1	0	2	0	1	0	6	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:109872840A>G	uc010sxn.1	+	20	2016	c.2016_splice	c.e20-2	p.K672_splice		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H							myosin complex	motor activity				0						TTTCACTTCTAGAACCAAAAT	0.254													16	27					0	0	0	0	G	109872840	G	G	109872840	5	3	3	1	0	0	0	0	0	0	1	0	10128	434	15	5	2092	5	MYO1H	12	109872840	Splice_Site	SNP	A	TCGA-BA-4076-01A-01D-1434-08	24422094	109872840	23979055	264	644											
TBX5	6910	broad.mit.edu	37	chr12	114836427	114836427	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgagcttgagtttctggaagGagacgagctgcctcatccaa	10	10	12	9	1	2	3	1	2	1	1	3	6	3	4	2	2	3	3	2	2	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:114836427G>C	uc001tvo.2	-	5	956	c.461C>G	c.(460-462)TCC>TGC	p.S154C	TBX5_uc001tvp.2_Missense_Mutation_p.S154C|TBX5_uc001tvq.2_Missense_Mutation_p.S104C|TBX5_uc010syv.1_Missense_Mutation_p.S154C	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	154	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TTTCTGGAAGGAGACGAGCTG	0.567													9	19					0	0	0	0	C	114836427	C	C	114836427	3	2	3	1	0	0	0	0	1	0	0	0	15727	1174	41	2	1182	2	TBX5	12	114836427	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	4963587	114836427	19015468	265	645											
FBXO21	23014	broad.mit.edu	37	chr12	117603318	117603318	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccagattcccaggtggaagTaaagcctggcttggaggagg	10	7	16	8	0	0	1	0	0	0	1	1	4	1	4	3	6	1	2	3	6	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:117603318T>C	uc001twk.2	-	9	1337	c.1298A>G	c.(1297-1299)TAC>TGC	p.Y433C	FBXO21_uc001twj.2_Missense_Mutation_p.Y433C|FBXO21_uc009zwq.2_Missense_Mutation_p.Y373C|FBXO21_uc001twl.1_Missense_Mutation_p.Y46C	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	433					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		CAGGTGGAAGTAAAGCCTGGC	0.512													94	132					0	0	0	0	C	117603318	C	C	117603318	3	2	3	1	0	0	0	0	1	0	0	0	5765	1638	57	5	604	5	FBXO21	12	117603318	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	2766891	117603318	16248577	266	646											
GOLGA3	2802	broad.mit.edu	37	chr12	133363016	133363016	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttggccgcgagggcctccTgcaggcggcggctgaggatg	4	6	18	13	4	0	1	0	1	0	0	1	3	1	2	4	6	1	2	4	6	0	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr12:133363016T>C	uc001ukz.1	-	15	3591	c.3032A>G	c.(3031-3033)CAG>CGG	p.Q1011R	GOLGA3_uc001ula.1_Missense_Mutation_p.Q1011R|GOLGA3_uc001ulb.2_Missense_Mutation_p.Q1011R	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1011	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GAGGGCCTCCTGCAGGCGGCG	0.652													10	28					0	0	0	0	C	133363016	C	C	133363016	3	2	3	1	0	0	0	0	1	0	0	0	6591	1580	55	5	1642	5	GOLGA3	12	133363016	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	15759698	133363016	488879	267	647											
RNF6	6049	broad.mit.edu	37	chr13	26793609	26793609	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttaccaggggtgcctaaaaGattatggtctctcataagcc	11	11	9	10	0	2	1	1	0	1	1	3	1	2	1	3	3	3	0	3	3	5	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr13:26793609G>C	uc001uqo.2	-	3	469	c.178C>G	c.(178-180)CTT>GTT	p.L60V	RNF6_uc001uqn.1_Missense_Mutation_p.L60V|RNF6_uc010aak.2_Missense_Mutation_p.L60V|RNF6_uc001uqp.2_Missense_Mutation_p.L60V|RNF6_uc001uqq.2_Missense_Mutation_p.L60V|RNF6_uc010tdk.1_Translation_Start_Site	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	60					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		GTGCCTAAAAGATTATGGTCT	0.383													58	73					0	0	0	0	C	26793609	C	C	26793609	3	2	3	1	0	0	0	0	1	0	0	0	13563	942	33	2	1891	2	RNF6	13	26793609	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08		26793609	88376269	268	648											
MTIF3	219402	broad.mit.edu	37	chr13	28011271	28011271	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatttcattttctgacacGtctacattttttcctttctt	7	21	2	11	1	4	1	1	1	3	0	5	1	5	1	2	0	1	0	2	0	1	9			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr13:28011271G>A	uc001urh.2	-	2	1824	c.600C>T	c.(598-600)GAC>GAT	p.D200D	MTIF3_uc001uri.2_Silent_p.D200D|MTIF3_uc001urj.2_Silent_p.D200D|MTIF3_uc001urk.2_Silent_p.D200D	NM_152912	NP_690876	Q9H2K0	IF3M_HUMAN	mitochondrial translational initiation factor 3	200					regulation of translational initiation|ribosome disassembly	mitochondrion	ribosomal small subunit binding|translation initiation factor activity			ovary(1)|skin(1)	2		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.108)|OV - Ovarian serous cystadenocarcinoma(117;0.157)		TTTCTGACACGTCTACATTTT	0.323													26	46					0	0	0	0	A	28011271	A	A	28011271	2	1	3	1	0	0	0	0	0	0	0	1	9988	1136	40	1		1	MTIF3	13	28011271	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	1217662	28011271	87158607	269	649											
C13orf36	400120	broad.mit.edu	37	chr13	37269514	37269514	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcatttcctctcagaggtCcactttttcaaacctttcat	9	15	4	13	0	3	1	3	0	1	1	6	1	5	1	3	1	2	1	3	1	1	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr13:37269514C>A	uc001uvt.3	+	2	745	c.299C>A	c.(298-300)TCC>TAC	p.S100Y		NM_203451	NP_982276	A2A2V5	CM036_HUMAN	hypothetical protein LOC400120	100						integral to membrane				skin(1)	1						TCTCAGAGGTCCACTTTTTCA	0.473													32	86					7.11191e-15	8.17075e-15	1	0	A	37269514	A	A	37269514	3	1	3	1	0	0	0	0	1	0	0	0	1736	855	30	2	301	2	C13orf36	13	37269514	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	9258243	37269514	77900364	270	650											
FAM48A	55578	broad.mit.edu	37	chr13	37619383	37619383	+	Splice_Site	DEL	C	-	-																															ctgtgctctagagggtcttaCctgatccgttttttcccctg																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr13:37619383delC	uc001uwg.2	-	6	540	c.292_splice	c.e6+1	p.D98_splice	FAM48A_uc010abt.2_Splice_Site_p.D99_splice|FAM48A_uc001uwh.2_Splice_Site_p.D99_splice|FAM48A_uc001uwi.2_Splice_Site_p.D98_splice|FAM48A_uc001uwj.2_Splice_Site_p.D99_splice|FAM48A_uc001uwk.2_Splice_Site_p.D98_splice|FAM48A_uc010tes.1_Splice_Site_p.D86_splice|FAM48A_uc001uwl.1_Splice_Site_p.D98_splice	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A						autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		GAGGGTCTTACCTGATCCGTT	0.413													---	---	---								-	37619383	-	-	37619383	8	5	3	1	0	1	0	1	0	0	1	0	5604	521	18	0	2130	0	FAM48A	13	37619383	Splice_Site	DEL	C	TCGA-BA-4076-01A-01D-1434-08	349869	37619383	77550495	271	651											
ESD	2098	broad.mit.edu	37	chr13	47351749	47351749	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggatttcacaaggtgggtagCatcataagcctgtaaaaaga	15	9	11	6	0	2	1	2	0	0	1	2	2	2	2	1	3	2	3	1	3	6	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr13:47351749C>A	uc001vbn.2	-	9	793	c.610G>T	c.(610-612)GCT>TCT	p.A204S	ESD_uc001vbo.2_Missense_Mutation_p.A204S|ESD_uc001vbp.1_Missense_Mutation_p.A62S	NM_001984	NP_001975	P10768	ESTD_HUMAN	esterase D/formylglutathione hydrolase	204						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			ovary(1)	1		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	AGGTGGGTAGCATCATAAGCC	0.343													71	120					4.83248e-46	7.03597e-46	1	0	A	47351749	A	A	47351749	3	1	3	1	0	0	0	0	1	0	0	0	5274	710	25	4	246	4	ESD	13	47351749	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	9732366	47351749	67818129	272	652											
ATP7B	540	broad.mit.edu	37	chr13	52520593	52520593	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccggatgatcacctctgtctGggagatgtgcttgttggggt	5	13	15	8	1	3	2	1	1	2	1	3	4	3	3	2	4	1	2	2	4	0	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr13:52520593G>T	uc001vfw.2	-	13	3044	c.2887C>A	c.(2887-2889)CAG>AAG	p.Q963K	ATP7B_uc010adv.2_Missense_Mutation_p.Q533K|ATP7B_uc001vfx.2_Missense_Mutation_p.Q756K|ATP7B_uc001vfy.2_Missense_Mutation_p.Q852K|ATP7B_uc010tgt.1_Intron|ATP7B_uc010tgu.1_Missense_Mutation_p.Q915K|ATP7B_uc010tgv.1_Missense_Mutation_p.Q885K|ATP7B_uc001vfv.2_Missense_Mutation_p.Q235K|ATP7B_uc010tgs.1_Missense_Mutation_p.Q235K	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	963	Extracellular (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ACCTCTGTCTGGGAGATGTGC	0.537									Wilson_disease				24	39					3.28513e-13	3.70979e-13	1	0	T	52520593	T	T	52520593	3	4	3	1	0	0	0	0	1	0	0	0	1193	1357	47	4	1546	4	ATP7B	13	52520593	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	5168844	52520593	62649285	273	653											
KLHL1	57626	broad.mit.edu	37	chr13	70413204	70413204	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cattaaagttcttctttctgGcaatagatggtatttcattg	10	18	7	6	0	4	1	1	0	3	1	4	1	4	1	0	2	0	3	0	2	5	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr13:70413204G>T	uc001vip.2	-	6	2112	c.1318C>A	c.(1318-1320)CCA>ACA	p.P440T	KLHL1_uc010thm.1_Missense_Mutation_p.P379T	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	440					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CTTCTTTCTGGCAATAGATGG	0.353													69	86					1.25706e-45	1.82451e-45	1	0	T	70413204	T	T	70413204	3	4	3	1	0	0	0	0	1	0	0	0	8404	1203	42	4	952	4	KLHL1	13	70413204	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	17892611	70413204	44756674	274	654											
SLITRK1	114798	broad.mit.edu	37	chr13	84454928	84454928	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgggggcttcgcagaccaCtcggccgatcagggcattct	6	8	15	12	3	2	1	1	0	1	1	4	2	2	1	2	5	0	3	2	5	0	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr13:84454928C>A	uc001vlk.2	-	1	1601	c.715G>T	c.(715-717)GTG>TTG	p.V239L		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	239	Extracellular (Potential).|LRRCT 1.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TCGCAGACCACTCGGCCGATC	0.527													36	53					2.6416e-12	2.95425e-12	1	0	A	84454928	A	A	84454928	3	1	3	1	0	0	0	0	1	0	0	0	14806	565	20	4	1379	4	SLITRK1	13	84454928	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	14041724	84454928	30714950	275	655											
ERCC5	2073	broad.mit.edu	37	chr13	103519118	103519118	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatctggctgtttggagcgcGgcatgtctatagaaactttt	8	15	11	7	2	2	1	0	0	2	1	2	2	2	2	0	3	2	3	0	3	4	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr13:103519118G>T	uc001vpw.2	+	11	2899	c.2456G>T	c.(2455-2457)CGG>CTG	p.R819L	ERCC5_uc001vpu.1_Missense_Mutation_p.R1273L|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.R651L	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	819	I-domain.				negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TTTGGAGCGCGGCATGTCTAT	0.428			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				32	46					3.11337e-16	3.64013e-16	1	0	T	103519118	T	T	103519118	3	4	3	1	0	0	0	0	1	0	0	0	5240	1116	39	3	2498	3	ERCC5	13	103519118	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	19064190	103519118	11650760	276	656											
TTC5	91875	broad.mit.edu	37	chr14	20768960	20768960	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agttagcattagaacttgtgCcttgccctggacagaaccta	11	11	9	10	0	0	2	0	0	0	2	0	3	0	3	3	1	5	2	3	1	5	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr14:20768960C>A	uc001vwt.2	-	3	259	c.202G>T	c.(202-204)GCA>TCA	p.A68S	TTC5_uc001vwu.2_5'UTR	NM_138376	NP_612385	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	68	TPR 1.				DNA repair	cytoplasm|nucleus	binding			ovary(1)	1	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		AGAACTTGTGCCTTGCCCTGG	0.438													236	181					4.9081e-105	7.54968e-105	1	0	A	20768960	A	A	20768960	3	1	3	1	0	0	0	0	1	0	0	0	16779	739	26	4	1152	4	TTC5	14	20768960	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08		20768960	86580580	277	657											
NDRG2	57447	broad.mit.edu	37	chr14	21491405	21491405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acggtctctaataaccttggCcgcctcaggcgtctgtcctg	6	11	10	14	3	3	0	1	0	2	0	5	0	4	0	4	3	1	0	4	3	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr14:21491405C>T	uc001vyy.2	-	3	220	c.70G>A	c.(70-72)GCC>ACC	p.A24T	NDRG2_uc010tll.1_Missense_Mutation_p.A34T|NDRG2_uc001vyt.2_5'Flank|NDRG2_uc001vyu.2_Missense_Mutation_p.A24T|NDRG2_uc001vyv.2_Missense_Mutation_p.A24T|NDRG2_uc001vyw.2_Missense_Mutation_p.A24T|NDRG2_uc001vzb.2_5'UTR|NDRG2_uc001vyx.2_Missense_Mutation_p.A24T|NDRG2_uc001vza.2_Missense_Mutation_p.A24T|NDRG2_uc001vyz.2_Missense_Mutation_p.A24T|NDRG2_uc001vzc.2_Missense_Mutation_p.A24T|NDRG2_uc001vze.2_Missense_Mutation_p.A24T|NDRG2_uc001vzd.2_Missense_Mutation_p.A24T|NDRG2_uc001vzg.2_Missense_Mutation_p.A24T|NDRG2_uc001vzf.2_Missense_Mutation_p.A24T|NDRG2_uc010aig.2_Missense_Mutation_p.A24T	NM_201540	NP_963834	Q9UN36	NDRG2_HUMAN	N-myc downstream-regulated gene 2 isoform a	24					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				ovary(1)|breast(1)	2	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		ATAACCTTGGCCGCCTCAGGC	0.537													3	43					0	0	0	0	T	21491405	T	T	21491405	3	4	3	1	0	0	0	0	1	0	0	0	10306	739	26	4	1105	4	NDRG2	14	21491405	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	722445	21491405	85858135	278	658											
MYH7	4625	broad.mit.edu	37	chr14	23886825	23886825	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggtgcttggtcttctccaGcgaggagcacttggcattaa	7	11	12	11	2	2	0	0	0	2	0	3	2	2	1	2	4	3	3	2	4	1	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr14:23886825G>A	uc001wjx.2	-	31	4346	c.4240C>T	c.(4240-4242)CTG>TTG	p.L1414L		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1414	Potential.		L -> M (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GTCTTCTCCAGCGAGGAGCAC	0.617													128	81					0	0	0	0	A	23886825	A	A	23886825	2	1	3	1	0	0	0	0	0	0	0	1	10092	962	34	4		4	MYH7	14	23886825	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	2395420	23886825	83462715	279	659											
SSTR1	6751	broad.mit.edu	37	chr14	38679295	38679295	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttctcatgggcttcctgcTgcccgtgggggctatctgcc	3	13	12	13	1	2	0	1	0	2	0	4	0	3	0	3	3	3	3	3	3	1	3	rs149523434		TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr14:38679295T>A	uc001wul.1	+	3	1318	c.701T>A	c.(700-702)CTG>CAG	p.L234Q	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	234	Helical; Name=5; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GGCTTCCTGCTGCCCGTGGGG	0.622													32	66					0	0	0	0	A	38679295	A	A	38679295	3	1	3	1	0	0	0	0	1	0	0	0	15263	1580	55	5	703	5	SSTR1	14	38679295	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	14792470	38679295	68670245	280	660											
PTGER2	5732	broad.mit.edu	37	chr14	52781369	52781369	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctccgtcatgttctcggccGgggtgctggggaacctcata	5	10	14	12	3	3	0	2	0	1	0	5	1	4	1	3	5	2	3	3	5	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr14:52781369G>A	uc001wzr.2	+	1	354	c.103G>A	c.(103-105)GGG>AGG	p.G35R		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	35	Helical; Name=1; (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	GTTCTCGGCCGGGGTGCTGGG	0.682													25	8					0	0	0	0	A	52781369	A	A	52781369	3	1	3	1	0	0	0	0	1	0	0	0	12806	1116	39	1	105	1	PTGER2	14	52781369	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	14102074	52781369	54568171	281	661											
YLPM1	56252	broad.mit.edu	37	chr14	75230942	75230942	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctactagctccaccaccaccGtccgccccccctggaaataa	10	6	5	20	2	0	0	0	0	0	0	2	1	2	1	8	1	2	1	8	1	4	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr14:75230942G>T	uc001xqj.3	+	1	874	c.750G>T	c.(748-750)CCG>CCT	p.P250P		NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	90	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CACCACCACCGTCCGCCCCCC	0.567													101	54					8.64784e-51	1.27514e-50	1	0	T	75230942	T	T	75230942	2	4	3	1	0	0	0	0	0	0	0	1	17554	1132	40	3		3	YLPM1	14	75230942	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	22449573	75230942	32118598	282	662											
MLH3	27030	broad.mit.edu	37	chr14	75500173	75500173	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgggcagcgtgctgatccaCcagcacgagcaggttcccac	9	6	12	14	2	0	1	0	1	0	0	2	2	2	1	3	2	4	5	3	2	0	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr14:75500173C>G	uc001xrd.1	-	7	3880	c.3664G>C	c.(3664-3666)GTG>CTG	p.V1222L	MLH3_uc001xre.1_Intron|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	1222					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TGCTGATCCACCAGCACGAGC	0.478								MMR					25	71					0	0	0	0	G	75500173	G	G	75500173	3	3	3	1	0	0	0	0	1	0	0	0	9671	507	18	4	725	4	MLH3	14	75500173	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	269231	75500173	31849367	283	663											
GALC	2581	broad.mit.edu	37	chr14	88434807	88434807	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtcaactttgcatctttTgctgaatgggttccaggata	9	14	9	9	0	2	1	1	1	1	0	3	2	3	2	2	2	3	3	2	2	3	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr14:88434807T>C	uc001xvt.2	-	8	1179	c.780A>G	c.(778-780)GCA>GCG	p.A260A	GALC_uc010tvw.1_RNA|GALC_uc010tvx.1_Silent_p.A234A|GALC_uc010tvy.1_Silent_p.A237A|GALC_uc010tvz.1_Silent_p.A204A|GALC_uc001xvu.1_Silent_p.A260A	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	260					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						TTGCATCTTTTGCTGAATGGG	0.413													73	94					0	0	0	0	C	88434807	C	C	88434807	2	2	3	1	0	0	0	0	0	0	0	1	6236	1799	63	5		5	GALC	14	88434807	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	12934634	88434807	18914733	284	664											
ZC3H14	79882	broad.mit.edu	37	chr14	89041117	89041117	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcaatcatgatggagaagaGgaggaagaagatgatgatta	17	9	13	2	0	2	7	2	3	0	4	2	10	2	9	0	3	0	0	0	3	5	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr14:89041117G>T	uc001xww.2	+	7	1167	c.942G>T	c.(940-942)GAG>GAT	p.E314D	ZC3H14_uc010twd.1_Missense_Mutation_p.E314D|ZC3H14_uc010twe.1_Missense_Mutation_p.E314D|ZC3H14_uc001xwx.2_Missense_Mutation_p.E314D|ZC3H14_uc010twf.1_Missense_Mutation_p.E159D|ZC3H14_uc001xwy.2_Missense_Mutation_p.E280D|ZC3H14_uc010twg.1_Missense_Mutation_p.E159D|ZC3H14_uc001xxa.2_5'Flank	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	314						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						ATGGAGAAGAGGAGGAAGAAG	0.413													27	55					2.44723e-14	2.79081e-14	1	0	T	89041117	T	T	89041117	3	4	3	1	0	0	0	0	1	0	0	0	17633	991	35	4	968	4	ZC3H14	14	89041117	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	606310	89041117	18308423	285	665											
FAM181A	90050	broad.mit.edu	37	chr14	94394802	94394802	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagtattcccggctcccgcgGggccttcctggcagagctgc	5	8	13	15	3	0	1	0	0	0	1	3	1	3	1	4	4	2	4	4	4	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr14:94394802G>T	uc001ybz.1	+	3	664	c.357G>T	c.(355-357)CGG>CGT	p.R119R	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Silent_p.R57R|FAM181A_uc001yca.1_Silent_p.R57R	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	119											0						GGCTCCCGCGGGGCCTTCCTG	0.657													21	33					7.41877e-09	7.93278e-09	1	0	T	94394802	T	T	94394802	2	4	3	1	0	0	0	0	0	0	0	1	5536	1219	43	4		4	FAM181A	14	94394802	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	5353685	94394802	12954738	286	666											
OR4M2	390538	broad.mit.edu	37	chr15	22368976	22368976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccgacccctccactatgctaCcatcatgaatcaacgtctct	10	10	4	17	2	3	1	2	1	1	0	5	2	4	1	5	0	3	1	5	0	4	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:22368976C>T	uc010tzu.1	+	1	401	c.401C>T	c.(400-402)ACC>ATC	p.T134I	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CACTATGCTACCATCATGAAT	0.507													88	797					0	0	0	0	T	22368976	T	T	22368976	3	4	3	1	0	0	0	0	1	0	0	0	11130	507	18	4	403	4	OR4M2	15	22368976	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08		22368976	80162416	287	667											
OR4N4	283694	broad.mit.edu	37	chr15	22382664	22382664	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctctatttatttctgggCaacttggccttcctggatgc	5	15	8	13	0	2	0	0	0	2	0	3	1	3	1	4	3	2	1	4	3	3	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:22382664C>A	uc001yuc.1	+	7	1173	c.192C>A	c.(190-192)GGC>GGA	p.G64G	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Silent_p.G64G	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TATTTCTGGGCAACTTGGCCT	0.463													61	589					1.7666e-45	2.55605e-45	1	0	A	22382664	A	A	22382664	2	1	3	1	0	0	0	0	0	0	0	1	11132	697	25	4		4	OR4N4	15	22382664	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	13688	22382664	80148728	288	668											
OR4N4	283694	broad.mit.edu	37	chr15	22382712	22382712	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccttcattgtggctcccagGatgttggtggacttcctctc	4	15	10	12	0	2	0	1	0	1	0	6	2	5	2	3	4	0	2	3	4	0	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:22382712G>A	uc001yuc.1	+	7	1221	c.240G>A	c.(238-240)AGG>AGA	p.R80R	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Silent_p.R80R	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGGCTCCCAGGATGTTGGTGG	0.512													28	597					0	0	0	0	A	22382712	A	A	22382712	2	1	3	1	0	0	0	0	0	0	0	1	11132	1165	41	2		2	OR4N4	15	22382712	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	48	22382712	80148680	289	669											
C15orf2	23742	broad.mit.edu	37	chr15	24921415	24921415	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttcaccacgtgagccggCggtcaaggccaggaagccca	9	4	13	15	3	2	1	2	1	0	0	2	2	2	2	5	4	2	0	5	4	2	1	rs139493881		TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:24921415C>T	uc001ywo.2	+	1	875	c.401C>T	c.(400-402)GCG>GTG	p.A134V		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	134					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CGTGAGCCGGCGGTCAAGGCC	0.632													71	16					0	0	0	0	T	24921415	T	T	24921415	3	4	3	1	0	0	0	0	1	0	0	0	1790	768	27	1	403	1	C15orf2	15	24921415	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2538703	24921415	77609977	290	670											
C15orf2	23742	broad.mit.edu	37	chr15	24922323	24922323	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacctggctactggacccCtcatcctgcctatccctcca	6	10	6	19	0	1	1	1	1	0	0	4	2	4	2	7	2	2	1	7	2	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:24922323C>A	uc001ywo.2	+	1	1783	c.1309C>A	c.(1309-1311)CTC>ATC	p.L437I		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	437	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TACTGGACCCCTCATCCTGCC	0.537													114	21					2.13259e-42	3.0475e-42	1	0	A	24922323	A	A	24922323	3	1	3	1	0	0	0	0	1	0	0	0	1790	681	24	4	1311	4	C15orf2	15	24922323	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	908	24922323	77609069	291	671											
OCA2	4948	broad.mit.edu	37	chr15	28230301	28230301	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagacagagcatgatgatcaTggcccacacccgtccccggg	10	5	12	14	2	1	4	1	2	0	2	2	5	2	4	4	2	1	1	4	2	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:28230301T>A	uc001zbh.3	-	13	1383	c.1273A>T	c.(1273-1275)ATG>TTG	p.M425L	OCA2_uc010ayv.2_Missense_Mutation_p.M401L	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	425	Helical; (Potential).		Missing (in OCA2; mild).		eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		ATGATGATCATGGCCCACACC	0.577									Oculocutaneous_Albinism				37	2					0	0	0	0	A	28230301	A	A	28230301	3	1	3	1	0	0	0	0	1	0	0	0	10869	1464	51	5	1291	5	OCA2	15	28230301	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	3307978	28230301	74301091	292	672											
FBN1	2200	broad.mit.edu	37	chr15	48752447	48752447	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccgtcatgactcaccaacGggtaaaccggtataaatgtc	12	9	9	11	3	2	1	2	1	0	0	3	1	2	1	3	2	3	2	3	2	6	3	rs111756438		TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:48752447G>A	uc001zwx.1	-	43	5620	c.5292C>T	c.(5290-5292)CCC>CCT	p.P1764P	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1764					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACTCACCAACGGGTAAACCGG	0.393													58	13					0	0	0	0	A	48752447	A	A	48752447	2	1	3	1	0	0	0	0	0	0	0	1	5734	1103	39	1		1	FBN1	15	48752447	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	20522146	48752447	53778945	293	673											
C15orf33	196951	broad.mit.edu	37	chr15	49663561	49663561	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggcaacgtatatgctcttgGgttgttcagaatctttataa	10	15	10	6	1	3	1	1	0	2	1	3	1	3	1	0	2	2	5	0	2	6	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:49663561G>T	uc001zxl.2	-	12	1342	c.1048C>A	c.(1048-1050)CCA>ACA	p.P350T		NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	350										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		TATGCTCTTGGGTTGTTCAGA	0.289													188	49					3.30089e-99	5.04393e-99	1	0	T	49663561	T	T	49663561	3	4	3	1	0	0	0	0	1	0	0	0	1797	1232	43	4	498	4	C15orf33	15	49663561	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	911114	49663561	52867831	294	674											
SLC27A2	11001	broad.mit.edu	37	chr15	50515307	50515307	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggcaatattggatttatgaAttatgcgagaaaagttggtg	14	13	12	2	1	0	2	0	1	0	1	0	4	0	3	0	3	1	2	0	3	7	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:50515307A>G	uc001zxw.2	+	5	1350	c.1118A>G	c.(1117-1119)AAT>AGT	p.N373S	SLC27A2_uc010bes.2_Missense_Mutation_p.N320S|SLC27A2_uc001zxx.2_Missense_Mutation_p.N138S	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	373	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		GGATTTATGAATTATGCGAGA	0.393													52	75					0	0	0	0	G	50515307	G	G	50515307	3	3	3	1	0	0	0	0	1	0	0	0	14590	101	4	5	1136	5	SLC27A2	15	50515307	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	851746	50515307	52016085	295	675											
UNC13C	440279	broad.mit.edu	37	chr15	54557618	54557618	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatccatatgttacagttCaagttggaaagaacaaaaga	17	10	9	5	0	1	3	1	1	0	2	2	4	2	4	1	1	2	3	1	1	7	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:54557618C>A	uc002ack.2	+	8	3742	c.3742C>A	c.(3742-3744)CAA>AAA	p.Q1248K	UNC13C_uc002acl.2_Missense_Mutation_p.Q78K	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1248	C2 1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGTTACAGTTCAAGTTGGAAA	0.323													10	11					0.000442599	0.000455386	1	0	A	54557618	A	A	54557618	3	1	3	1	0	0	0	0	1	0	0	0	17054	827	29	2	3772	2	UNC13C	15	54557618	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	4042311	54557618	47973774	296	676											
NOX5	79400	broad.mit.edu	37	chr15	69335139	69335139	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagaaagagtcaaaggtcGtccaaggtaggtggctactg	13	8	14	6	1	1	2	1	1	0	2	3	3	2	2	1	4	1	2	1	4	5	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:69335139G>T	uc002ars.1	+	10	1661	c.1641G>T	c.(1639-1641)TCG>TCT	p.S547S	NOX5_uc002arp.1_Silent_p.S529S|NOX5_uc002arq.1_Silent_p.S501S|NOX5_uc010bid.1_Silent_p.S512S|NOX5_uc002arr.1_Silent_p.S519S|NOX5_uc010bie.1_Silent_p.S347S|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	547	FAD-binding FR-type.|Cytoplasmic (Potential).|C-terminal catalytic region.				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						GTCAAAGGTCGTCCAAGGTAG	0.527													40	7					3.61848e-18	4.29578e-18	1	0	T	69335139	T	T	69335139	2	4	3	1	0	0	0	0	0	0	0	1	10613	1132	40	3		3	NOX5	15	69335139	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	14777521	69335139	33196253	297	677											
KIAA1024	23251	broad.mit.edu	37	chr15	79749833	79749833	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcccctgttgacctggagaaGcatgaaccagtcaaaaagtt	13	9	9	10	0	1	3	1	2	0	1	2	4	2	3	4	1	2	3	4	1	4	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:79749833G>C	uc002bew.1	+	2	1419	c.1344G>C	c.(1342-1344)AAG>AAC	p.K448N	KIAA1024_uc010unk.1_Missense_Mutation_p.K448N	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	448						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						ACCTGGAGAAGCATGAACCAG	0.488													64	19					0	0	0	0	C	79749833	C	C	79749833	3	2	3	1	0	0	0	0	1	0	0	0	8244	962	34	4	1346	4	KIAA1024	15	79749833	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	10414694	79749833	22781559	298	678											
C15orf32	145858	broad.mit.edu	37	chr15	93015432	93015432	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaagacttgcacccggctgaCccccagagtggggaaggggt	9	5	16	11	1	0	3	0	1	0	2	0	5	0	4	3	5	1	2	3	5	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr15:93015432C>A	uc002brc.1	+	1	526	c.54C>A	c.(52-54)GAC>GAA	p.D18E	C15orf32_uc010bod.1_RNA	NM_153040	NP_694585	Q32M92	CO032_HUMAN	hypothetical protein LOC145858	18										ovary(1)	1	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			ACCCGGCTGACCCCCAGAGTG	0.408													74	16					9.21137e-24	1.16209e-23	1	0	A	93015432	A	A	93015432	3	1	3	1	0	0	0	0	1	0	0	0	1796	506	18	4	56	4	C15orf32	15	93015432	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	13265599	93015432	9515960	299	679											
STUB1	10273	broad.mit.edu	37	chr16	732421	732421	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgacccaggaacagctcatcCccaacttggctatgaaggag	12	7	10	12	0	1	2	1	2	0	0	2	4	2	4	3	3	3	2	3	3	4	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:732421C>T	uc002cit.2	+	7	1255	c.844C>T	c.(844-846)CCC>TCC	p.P282S	STUB1_uc002ciu.2_Missense_Mutation_p.P210S|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA|JMJD8_uc002ciw.1_3'UTR|JMJD8_uc002cix.1_3'UTR|JMJD8_uc002ciy.1_3'UTR	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	282	U-box.				cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				ACAGCTCATCCCCAACTTGGC	0.592													47	64					0	0	0	0	T	732421	T	T	732421	3	4	3	1	0	0	0	0	1	0	0	0	15401	623	22	4	870	4	STUB1	16	732421	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08		732421	89622332	300	680											
PTX4	390667	broad.mit.edu	37	chr16	1536306	1536306	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatgtggtgccactggccGtccagcagcagctgcaaggg	8	6	15	12	1	0	1	0	0	0	1	1	1	1	1	3	3	5	4	3	3	1	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:1536306G>T	uc010uvf.1	-	3	1056	c.1056C>A	c.(1054-1056)GAC>GAA	p.D352E		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	357	Pentaxin.					extracellular region	metal ion binding				0						GCCACTGGCCGTCCAGCAGCA	0.672													28	31					2.12542e-12	2.38273e-12	1	0	T	1536306	T	T	1536306	3	4	3	1	0	0	0	0	1	0	0	0	12888	1136	40	3	368	3	PTX4	16	1536306	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	803885	1536306	88818447	301	681											
CREBBP	1387	broad.mit.edu	37	chr16	3778856	3778856	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcaggtcttgcagagcgctGggtgagatgctcctgggtgg	6	9	18	8	1	1	2	0	1	1	2	2	3	2	2	1	4	4	4	1	4	0	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:3778856G>A	uc002cvv.2	-	31	6396	c.6192C>T	c.(6190-6192)CCC>CCT	p.P2064P	CREBBP_uc002cvw.2_Silent_p.P2026P	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	2064					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCAGAGCGCTGGGTGAGATGC	0.642			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				23	41					0	0	0	0	A	3778856	A	A	3778856	2	1	3	1	0	0	0	0	0	0	0	1	3876	1335	47	4		4	CREBBP	16	3778856	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	2242550	3778856	86575897	302	682											
GLYR1	84656	broad.mit.edu	37	chr16	4855258	4855258	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagtgtatgtaggctcggtaCacggcggacatatcgttgtc	8	12	13	8	4	0	0	0	0	0	0	3	1	0	1	0	4	1	5	0	4	5	6	rs138196315	by1000genomes	TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:4855258C>A	uc002cxx.3	-	16	1678	c.1641G>T	c.(1639-1641)GTG>GTT	p.V547V	ROGDI_uc002cxv.2_5'Flank|ROGDI_uc010bua.2_5'Flank|ROGDI_uc002cxw.2_5'Flank|ROGDI_uc010bub.1_5'Flank|ROGDI_uc010uxu.1_5'Flank|GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Silent_p.V461V|GLYR1_uc002cya.2_Silent_p.V541V|GLYR1_uc010uxv.1_Silent_p.V466V	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	547					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						AGGCTCGGTACACGGCGGACA	0.592													11	26					6.72482e-11	7.3261e-11	1	0	A	4855258	A	A	4855258	2	1	3	1	0	0	0	0	0	0	0	1	6520	465	17	4		4	GLYR1	16	4855258	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1076402	4855258	85499495	303	683											
ACSM5	54988	broad.mit.edu	37	chr16	20430642	20430642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaagtccattatcaccagtGactccctagctccaagggtg	10	9	8	14	0	1	1	1	1	0	0	4	1	4	1	5	1	1	1	5	1	4	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:20430642G>A	uc002dhe.2	+	4	655	c.508G>A	c.(508-510)GAC>AAC	p.D170N	ACSM5_uc002dhd.1_Missense_Mutation_p.D170N	NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	170					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TATCACCAGTGACTCCCTAGC	0.582													39	55					0	0	0	0	A	20430642	A	A	20430642	3	1	3	1	0	0	0	0	1	0	0	0	187	1290	45	2	518	2	ACSM5	16	20430642	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	15575384	20430642	69924111	304	684											
ACSM3	6296	broad.mit.edu	37	chr16	20787221	20787221	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagaaatggagaagagatgCgatggagttttgaggaactg	15	8	15	3	1	0	4	0	1	0	3	0	9	0	6	0	3	2	1	0	3	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:20787221C>A	uc002dhr.2	+	3	467	c.280C>A	c.(280-282)CGA>AGA	p.R94R	ACSM3_uc002dhq.2_Silent_p.R94R|ACSM3_uc010vba.1_Silent_p.R86R	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	94					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						AGAAGAGATGCGATGGAGTTT	0.413													111	144					5.67207e-43	8.1558e-43	1	0	A	20787221	A	A	20787221	2	1	3	1	0	0	0	0	0	0	0	1	185	760	27	3		3	ACSM3	16	20787221	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	356579	20787221	69567532	305	685											
ZP2	7783	broad.mit.edu	37	chr16	21213115	21213115	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaacgttgatgtttagtagCatgtcattcctgctataaga	11	15	8	7	1	2	2	2	1	0	1	3	2	3	2	1	0	3	5	1	0	5	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:21213115C>T	uc002dii.2	-	13	1416	c.1416G>A	c.(1414-1416)ATG>ATA	p.M472I	ZP2_uc010bwn.1_Missense_Mutation_p.M502I	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	472	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		TGTTTAGTAGCATGTCATTCC	0.413													83	120					0	0	0	0	T	21213115	T	T	21213115	3	4	3	1	0	0	0	0	1	0	0	0	18283	710	25	4	849	4	ZP2	16	21213115	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	425894	21213115	69141638	306	686											
PRKCB	5579	broad.mit.edu	37	chr16	23847649	23847649	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagcagcccaccttctgcagCcactgcaccgacttcatctg	9	8	7	17	1	3	0	1	0	2	0	3	1	3	0	4	0	5	3	4	0	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:23847649C>G	uc002dmd.2	+	1	350	c.153C>G	c.(151-153)AGC>AGG	p.S51R	PRKCB_uc002dme.2_Missense_Mutation_p.S51R	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	51	Phorbol-ester/DAG-type 1.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CCTTCTGCAGCCACTGCACCG	0.627													45	73					0	0	0	0	G	23847649	G	G	23847649	3	3	3	1	0	0	0	0	1	0	0	0	12570	738	26	4	155	4	PRKCB	16	23847649	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2634534	23847649	66507104	307	687											
ARHGAP17	55114	broad.mit.edu	37	chr16	24980015	24980015	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagagggtccacgatctcCttctcaacaaagacttcgtg	11	10	8	12	2	2	2	1	0	2	2	6	3	3	2	2	1	2	0	2	1	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:24980015C>A	uc002dnb.2	-	5	444	c.351G>T	c.(349-351)AAG>AAT	p.K117N	ARHGAP17_uc002dnc.2_Missense_Mutation_p.K117N|ARHGAP17_uc010vcf.1_Translation_Start_Site|ARHGAP17_uc002dnf.2_Missense_Mutation_p.K25N|ARHGAP17_uc002dng.1_Missense_Mutation_p.K117N	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	117	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CCACGATCTCCTTCTCAACAA	0.537													86	109					2.58158e-40	3.64412e-40	1	0	A	24980015	A	A	24980015	3	1	3	1	0	0	0	0	1	0	0	0	867	680	24	4	2358	4	ARHGAP17	16	24980015	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1132366	24980015	65374738	308	688											
RBL2	5934	broad.mit.edu	37	chr16	53503839	53503839	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgaccctaggcataacatctCcaaccacattatacgatagg	14	9	6	12	1	1	1	0	1	1	0	2	2	1	1	3	2	3	1	3	2	6	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:53503839C>G	uc002ehi.3	+	15	2105	c.1987C>G	c.(1987-1989)CCA>GCA	p.P663A	RBL2_uc010vgv.1_Missense_Mutation_p.P589A|RBL2_uc002ehj.2_Missense_Mutation_p.P373A|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	663	Spacer.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						CATAACATCTCCAACCACATT	0.453													69	58					0	0	0	0	G	53503839	G	G	53503839	3	3	3	1	0	0	0	0	1	0	0	0	13175	855	30	2	2045	2	RBL2	16	53503839	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	28523824	53503839	36850914	309	689											
CIRH1A	84916	broad.mit.edu	37	chr16	69184450	69184450	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aattcctcagcaagaagacaGtttcgtggtgggcacagccg	11	8	12	10	2	1	2	1	0	0	2	3	2	2	2	2	2	2	3	2	2	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:69184450G>T	uc002ews.3	+	7	845	c.749G>T	c.(748-750)AGT>ATT	p.S250I	CIRH1A_uc002ewr.2_Missense_Mutation_p.S250I|CIRH1A_uc002ewt.3_Missense_Mutation_p.S167I|CIRH1A_uc010cfi.2_Missense_Mutation_p.S167I|CIRH1A_uc010cfj.1_Missense_Mutation_p.S69I	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	250	WD 6.					nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		CAAGAAGACAGTTTCGTGGTG	0.488											OREG0023906	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	485	93					1.38385e-241	2.1646e-241	1	0	T	69184450	T	T	69184450	3	4	3	1	0	0	0	0	1	0	0	0	3449	1029	36	4	771	4	CIRH1A	16	69184450	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	15680611	69184450	21170303	310	690											
ZNF23	7571	broad.mit.edu	37	chr16	71483245	71483245	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgaagcttttcccacacTccacacatttgaagggtttc	10	12	7	12	0	0	2	0	2	0	0	3	2	2	2	2	1	2	3	2	1	2	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:71483245T>C	uc002faf.2	-	6	1497	c.683A>G	c.(682-684)GAG>GGG	p.E228G	ZNF23_uc002fad.2_Missense_Mutation_p.E170G|ZNF23_uc002fae.2_Missense_Mutation_p.E170G|ZNF23_uc010vmf.1_Missense_Mutation_p.E170G|ZNF23_uc002fag.2_Missense_Mutation_p.E170G|ZNF23_uc002fah.2_Missense_Mutation_p.E228G|ZNF23_uc002fai.2_Missense_Mutation_p.E267G	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	228	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		TTTCCCACACTCCACACATTT	0.453													51	592					0	0	0	0	C	71483245	C	C	71483245	3	2	3	1	0	0	0	0	1	0	0	0	17850	1551	54	5	1252	5	ZNF23	16	71483245	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	2298795	71483245	18871508	311	691											
BCAR1	9564	broad.mit.edu	37	chr16	75269450	75269450	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctccaggggttcccggccCggccctgccacctccaagga	6	5	12	18	2	0	0	0	0	0	0	3	1	3	1	7	5	2	2	7	5	1	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:75269450C>A	uc002fdv.2	-	5	1470	c.1347G>T	c.(1345-1347)CCG>CCT	p.P449P	BCAR1_uc002fdt.2_5'UTR|BCAR1_uc002fdu.2_Silent_p.P239P|BCAR1_uc010cgu.2_Silent_p.P438P|BCAR1_uc010vna.1_Silent_p.P447P|BCAR1_uc010vnb.1_Silent_p.P495P|BCAR1_uc002fdw.2_Silent_p.P449P|BCAR1_uc010vnc.1_Silent_p.P301P|BCAR1_uc010vnd.1_Silent_p.P467P|BCAR1_uc002fdx.2_Silent_p.P467P	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	449	Ser-rich.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		GTTCCCGGCCCGGCCCTGCCA	0.697													17	3					7.07596e-05	7.36218e-05	1	0	A	75269450	A	A	75269450	2	1	3	1	0	0	0	0	0	0	0	1	1350	639	23	3		3	BCAR1	16	75269450	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	3786205	75269450	15085303	312	692											
C16orf46	123775	broad.mit.edu	37	chr16	81094970	81094970	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagctttgcactccccgtttCtgcagaagctgcaaggcagc	8	10	10	13	1	1	1	0	0	1	1	2	1	2	1	2	1	6	7	2	1	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr16:81094970C>T	uc002fgc.3	-	4	1243	c.984G>A	c.(982-984)CAG>CAA	p.Q328Q	C16orf46_uc010chf.2_Silent_p.Q328Q|C16orf46_uc010vno.1_Silent_p.Q55Q	NM_152337	NP_689550	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 2	328											0						CTCCCCGTTTCTGCAGAAGCT	0.542													72	120					0	0	0	0	T	81094970	T	T	81094970	2	4	3	1	0	0	0	0	0	0	0	1	1821	912	32	2		2	C16orf46	16	81094970	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5825520	81094970	9259783	313	693											
TSR1	55720	broad.mit.edu	37	chr17	2238189	2238189	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatcccctggacagctagTgctgtaagcgaaagagaaaa	16	6	11	8	1	0	1	0	0	0	1	1	5	1	2	2	1	3	3	2	1	6	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:2238189T>A	uc002fuj.2	-	5	1515	c.558A>T	c.(556-558)ACA>ACT	p.T186T	SGSM2_uc002fum.3_5'Flank|SGSM2_uc010vqw.1_5'Flank|SGSM2_uc002fun.3_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	186					ribosome assembly	nucleolus	protein binding			ovary(1)	1						GGACAGCTAGTGCTGTAAGCG	0.453													80	98					0	0	0	0	A	2238189	A	A	2238189	2	1	3	1	0	0	0	0	0	0	0	1	16731	1710	59	5		5	TSR1	17	2238189	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08		2238189	78957021	314	694											
NEURL4	84461	broad.mit.edu	37	chr17	7230998	7230998	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaagctccccagcaactgtgCgctccacgcccacgcggtcc	7	5	10	19	4	0	0	0	0	0	0	3	1	3	0	5	1	4	3	5	1	2	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:7230998C>T	uc002gga.1	-	2	495	c.488G>A	c.(487-489)CGC>CAC	p.R163H	NEURL4_uc002ggb.1_Missense_Mutation_p.R163H|NEURL4_uc002ggc.1_5'Flank	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	163	NHR 1.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						AGCAACTGTGCGCTCCACGCC	0.642													65	95					0	0	0	0	T	7230998	T	T	7230998	3	4	3	1	0	0	0	0	1	0	0	0	10401	768	27	1	4312	1	NEURL4	17	7230998	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	4992809	7230998	73964212	315	695											
TP53	7157	broad.mit.edu	37	chr17	7578523	7578523	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggcaggtcttggccagtTggcaaaacatcttgttgagg	9	10	14	8	0	2	1	0	1	2	0	2	1	2	1	1	5	1	4	1	5	2	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:7578523T>G	uc002gim.2	-	5	601	c.407A>C	c.(406-408)CAA>CCA	p.Q136P	TP53_uc002gig.1_Missense_Mutation_p.Q136P|TP53_uc002gih.2_Missense_Mutation_p.Q136P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Q4P|TP53_uc010cng.1_Missense_Mutation_p.Q4P|TP53_uc002gii.1_Missense_Mutation_p.Q4P|TP53_uc010cnh.1_Missense_Mutation_p.Q136P|TP53_uc010cni.1_Missense_Mutation_p.Q136P|TP53_uc002gij.2_Missense_Mutation_p.Q136P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Q43P|TP53_uc002gio.2_Missense_Mutation_p.Q4P|TP53_uc010vug.1_Missense_Mutation_p.Q97P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	136	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q136*(28)|p.0?(7)|p.Q136H(5)|p.Q136Q(4)|p.Q136P(3)|p.Q136E(3)|p.Q136fs*13(2)|p.N131fs*27(2)|p.Q136fs*34(2)|p.Q136R(2)|p.V73fs*9(1)|p.F134_T140>S(1)|p.C135_T140delCQLAKT(1)|p.Q136K(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.Q136_K139delQLAK(1)|p.C135_Q136insX(1)|p.C135_Q136insXXXXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTGGCCAGTTGGCAAAACAT	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	39					0	0	0	0	G	7578523	G	G	7578523	3	3	3	1	0	0	0	0	1	0	0	0	16448	1812	63	5	891	5	TP53	17	7578523	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	347525	7578523	73616687	316	696											
PER1	5187	broad.mit.edu	37	chr17	8044494	8044495	+	Missense_Mutation	DNP	TT	AA	AA																															cttgaagccttggccccgccTtgggcctcctcgcagccctc																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:8044494_8044495TT>AA	uc002gkd.2	-	23	4002_4003	c.3764_3765AA>TT	c.(3763-3765)CAA>CTT	p.Q1255L	PER1_uc010cns.2_Missense_Mutation_p.Q129L|PER1_uc010vuq.1_RNA	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	1255	CRY binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						TGGCCCCGCCTTGGGCCTCCTC	0.639			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					179	268					0	0	0	0	AA	8044495	AA	AA	8044494	3	1	3	1	0	0	0	0	1	0	0	0	11783	1606	56	5	111	5	PER1	17	8044494	Missense_Mutation	DNP	TT	TCGA-BA-4076-01A-01D-1434-08	465971	8044494	73150716	317	697											
PIK3R6	146850	broad.mit.edu	37	chr17	8732225	8732225	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccaactcccggtccggccgGaggccctgcagatccaagac	8	4	12	17	3	0	2	0	0	0	2	3	3	3	3	6	4	2	1	6	4	2	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:8732225G>T	uc002glq.1	-	11	1212	c.972C>A	c.(970-972)CTC>CTA	p.L324L	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	324					platelet activation	cytosol					0						GGTCCGGCCGGAGGCCCTGCA	0.657													14	23					1.5842e-08	1.69006e-08	1	0	T	8732225	T	T	8732225	2	4	3	1	0	0	0	0	0	0	0	1	11978	1161	41	2		2	PIK3R6	17	8732225	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	687731	8732225	72462985	318	698											
MAP2K3	5606	broad.mit.edu	37	chr17	21204272	21204272	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcacggtcgactgtttctaCactgtcaccttctacggggc	6	11	10	14	4	3	0	1	0	2	0	4	1	3	0	1	3	2	2	1	3	2	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:21204272C>G	uc002gys.2	+	5	631	c.366C>G	c.(364-366)TAC>TAG	p.Y122*	MAP2K3_uc002gyt.2_Nonsense_Mutation_p.Y93*|MAP2K3_uc002gyu.2_Nonsense_Mutation_p.Y93*	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	122	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		ACTGTTTCTACACTGTCACCT	0.592													4	183					0	0	0	0	G	21204272	G	G	21204272	4	3	3	1	0	0	0	0	0	1	0	0	9291	489	17	4	384	4	MAP2K3	17	21204272	Nonsense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	12472047	21204272	59990938	319	699											
KCNJ12	3768	broad.mit.edu	37	chr17	21319071	21319071	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttcctcttctccatcgaGacgcagaccaccatcggcta	8	9	7	17	3	2	2	0	0	2	2	6	3	3	2	5	1	0	2	5	1	1	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:21319071G>T	uc002gyv.1	+	3	1122	c.417G>T	c.(415-417)GAG>GAT	p.E139D		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	139				E -> K (in Ref. 2; AAC50615).	blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TCTCCATCGAGACGCAGACCA	0.672										Prostate(3;0.18)			7	22					0.000442599	0.000455386	1	0	T	21319071	T	T	21319071	3	4	3	1	0	0	0	0	1	0	0	0	8085	933	33	2	419	2	KCNJ12	17	21319071	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	114799	21319071	59876139	320	700											
ATAD5	79915	broad.mit.edu	37	chr17	29220783	29220783	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacaactgcaggaaaaaaaTgttctgcccttgtttctcat	14	12	6	9	0	2	0	1	0	2	0	3	1	2	1	1	1	4	3	1	1	5	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:29220783T>A	uc002hfs.1	+	21	5258	c.4912T>A	c.(4912-4914)TGT>AGT	p.C1638S		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1638					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGGAAAAAAATGTTCTGCCCT	0.378													106	180					0	0	0	0	A	29220783	A	A	29220783	3	1	3	1	0	0	0	0	1	0	0	0	1078	1464	51	5	4994	5	ATAD5	17	29220783	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	7901712	29220783	51974427	321	701											
MYO1D	4642	broad.mit.edu	37	chr17	31107692	31107692	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggtctctcatacagctcaCggcctttatactgctcaatt	8	13	7	13	2	4	0	3	0	1	0	5	0	4	0	1	2	4	2	1	2	4	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:31107692C>T	uc002hho.1	-	2	218	c.206G>A	c.(205-207)CGT>CAT	p.R69H	MYO1D_uc002hhp.1_Missense_Mutation_p.R69H|MYO1D_uc010wcb.1_Missense_Mutation_p.R69H	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	69	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			ATACAGCTCACGGCCTTTATA	0.448													67	73					0	0	0	0	T	31107692	T	T	31107692	3	4	3	1	0	0	0	0	1	0	0	0	10124	536	19	1	2898	1	MYO1D	17	31107692	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	1886909	31107692	50087518	322	702											
UNC45B	146862	broad.mit.edu	37	chr17	33501357	33501357	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaagcagatagtgccatcCtcactgaccagaccaaggag	14	6	10	11	0	1	4	1	2	0	2	2	5	2	5	4	1	2	1	4	1	3	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:33501357C>G	uc002hja.2	+	14	2030	c.1933C>G	c.(1933-1935)CTC>GTC	p.L645V	UNC45B_uc002hjb.2_Missense_Mutation_p.L643V|UNC45B_uc002hjc.2_Missense_Mutation_p.L643V|UNC45B_uc010cto.2_Missense_Mutation_p.L564V	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	645					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				TAGTGCCATCCTCACTGACCA	0.597													4	108					0	0	0	0	G	33501357	G	G	33501357	3	3	3	1	0	0	0	0	1	0	0	0	17057	681	24	4	1983	4	UNC45B	17	33501357	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2393665	33501357	47693853	323	703											
CSH2	1443	broad.mit.edu	37	chr17	61952951	61952952	+	5'Flank	DEL	TC	-	-																															tctttctttctttctttcttTctttctttctttctttcttt																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr17:61952951_61952952delTC	uc002jch.2	-						CSH2_uc002jcg.2_5'Flank|CSH2_uc002jci.2_5'Flank|GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Intron	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1						female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						tttctttctttctttctttctt	0													---	---	---								-	61952952	-	-	61952951	6	5	3	0	1	1	0	1	0	0	0	0	3958	1798	62	0		0	CSH2	17	61952951	5'Flank	DEL	TC	TCGA-BA-4076-01A-01D-1434-08	28451594	61952951	19242259	324	704											
SMCHD1	23347	broad.mit.edu	37	chr18	2751280	2751280	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgtttaccatgacagatttTatgattagtgttatttctga	11	18	7	5	1	1	4	0	3	1	1	1	4	1	4	1	0	1	2	1	0	4	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr18:2751280T>C	uc002klm.3	+	33	4359	c.4170T>C	c.(4168-4170)TTT>TTC	p.F1390F	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1390					chromosome organization		ATP binding				0						TGACAGATTTTATGATTAGTG	0.303													17	334					0	0	0	0	C	2751280	C	C	2751280	2	2	3	1	0	0	0	0	0	0	0	1	14852	1751	61	5		5	SMCHD1	18	2751280	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08		2751280	75325968	325	705											
ARHGAP28	79822	broad.mit.edu	37	chr18	6882171	6882172	+	Missense_Mutation	DNP	TG	GT	GT																															cttgatgccaagtttaatgcTgataaatttaaatgggacaa																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr18:6882171_6882172TG>GT	uc010wzi.1	+	10	1033_1034	c.795_796TG>GT	c.(793-798)GCTGAT>GCGTAT	p.D266Y	ARHGAP28_uc002knc.2_Missense_Mutation_p.D391Y|ARHGAP28_uc002knd.2_Missense_Mutation_p.D284Y|ARHGAP28_uc002kne.2_Missense_Mutation_p.D284Y|ARHGAP28_uc002knf.2_Missense_Mutation_p.D275Y			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	266					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				AGTTTAATGCTGATAAATTTAA	0.396													131	80					0	0	0	0	GT	6882172	GT	GT	6882171	3	3	3	1	0	0	0	0	1	0	0	0	877	1567	55	5	883	5	ARHGAP28	18	6882171	Missense_Mutation	DNP	TG	TCGA-BA-4076-01A-01D-1434-08	4130891	6882171	71195077	326	706											
LAMA1	284217	broad.mit.edu	37	chr18	7015791	7015791	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacttcacaccctgtgtgTgaggggggcagacacactct	9	8	11	13	0	2	2	1	1	1	1	2	2	2	2	1	3	0	1	1	3	0	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr18:7015791T>C	uc002knm.2	-	22	3150	c.3056A>G	c.(3055-3057)CAC>CGC	p.H1019R	LAMA1_uc010wzj.1_Missense_Mutation_p.H495R	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1019	Laminin EGF-like 11.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCCTGTGTGTGAGGGGGGCA	0.542													70	259					0	0	0	0	C	7015791	C	C	7015791	3	2	3	1	0	0	0	0	1	0	0	0	8645	1696	59	5	6339	5	LAMA1	18	7015791	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	133620	7015791	71061457	327	707											
PPP4R1	9989	broad.mit.edu	37	chr18	9563520	9563520	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcatccaggctggaagcacgTagtgcagcggacagcacttc	10	6	13	12	2	0	0	0	0	0	0	2	2	1	2	1	3	4	6	1	3	2	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr18:9563520T>A	uc002koe.1	-	12	1720	c.1602A>T	c.(1600-1602)CTA>CTT	p.L534L	PPP4R1_uc002kof.2_5'UTR|PPP4R1_uc010wzo.1_Silent_p.L380L|PPP4R1_uc002kod.1_Silent_p.L517L|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	534	HEAT 10.				protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						TGGAAGCACGTAGTGCAGCGG	0.403													47	163					0	0	0	0	A	9563520	A	A	9563520	2	1	3	1	0	0	0	0	0	0	0	1	12463	1625	57	5		5	PPP4R1	18	9563520	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	2547729	9563520	68513728	328	708											
ANKRD30B	374860	broad.mit.edu	37	chr18	14852103	14852103	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaacatgcacaaagagaccGatgtgaaacacagtgtcaaa	19	5	9	8	1	1	3	1	1	0	2	1	5	1	3	1	0	3	1	1	0	4	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr18:14852103G>A	uc010dlo.2	+	36	3983	c.3803G>A	c.(3802-3804)CGA>CAA	p.R1268Q	ANKRD30B_uc010xal.1_Missense_Mutation_p.R410Q	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1353										ovary(1)|skin(1)	2						CAAAGAGACCGATGTGAAACA	0.388													7	32					0	0	0	0	A	14852103	A	A	14852103	3	1	3	1	0	0	0	0	1	0	0	0	659	1058	37	1	3945	1	ANKRD30B	18	14852103	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	5288583	14852103	63225145	329	709											
ROCK1	6093	broad.mit.edu	37	chr18	18600198	18600198	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attgttttttgcaaactttcCtgctttaatttaaaacaaaa	14	18	3	6	0	0	0	0	0	0	0	1	0	1	0	1	0	4	3	1	0	6	9			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr18:18600198C>A	uc002kte.2	-	12	2216	c.1275G>T	c.(1273-1275)CAG>CAT	p.Q425H		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	425	Interaction with FHOD1.|Potential.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					GCAAACTTTCCTGCTTTAATT	0.269													21	48					7.45023e-12	8.21299e-12	1	0	A	18600198	A	A	18600198	3	1	3	1	0	0	0	0	1	0	0	0	13582	680	24	4	2877	4	ROCK1	18	18600198	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	3748095	18600198	59477050	330	710											
NPC1	4864	broad.mit.edu	37	chr18	21124402	21124402	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caatgagggtcaagggcaacCcaatgtagctgaagacaccc	14	5	11	11	0	1	3	1	2	0	1	1	3	1	3	2	2	2	3	2	2	6	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr18:21124402C>A	uc002kum.3	-	13	2310	c.2036G>T	c.(2035-2037)GGG>GTG	p.G679V	NPC1_uc010xaz.1_Missense_Mutation_p.G412V|NPC1_uc010xba.1_Missense_Mutation_p.G524V	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	679	SSD.|Helical; (Potential).				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CAAGGGCAACCCAATGTAGCT	0.547													161	53					1.11508e-49	1.6338e-49	1	0	A	21124402	A	A	21124402	3	1	3	1	0	0	0	0	1	0	0	0	10624	623	22	4	1852	4	NPC1	18	21124402	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	2524204	21124402	56952846	331	711											
ASXL3	80816	broad.mit.edu	37	chr18	31318971	31318971	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagaaatgacagttgttatcGatcagttagaagtctgtgac	14	12	10	5	1	2	4	1	2	1	2	3	5	2	4	0	0	0	3	0	0	5	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr18:31318971G>A	uc010dmg.1	+	11	1658	c.1603G>A	c.(1603-1605)GAT>AAT	p.D535N	ASXL3_uc002kxq.2_Missense_Mutation_p.D242N	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AGTTGTTATCGATCAGTTAGA	0.393													14	57					0	0	0	0	A	31318971	A	A	31318971	3	1	3	1	0	0	0	0	1	0	0	0	1070	1058	37	1	1645	1	ASXL3	18	31318971	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	10194569	31318971	46758277	332	712											
ASXL3	80816	broad.mit.edu	37	chr18	31326256	31326256	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgcaggtgcagcaacaacaGcagctctgtggaaattatcc	13	8	10	10	0	1	0	0	0	1	0	2	1	2	1	1	2	7	5	1	2	4	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr18:31326256G>T	uc010dmg.1	+	12	6499	c.6444G>T	c.(6442-6444)CAG>CAT	p.Q2148H	ASXL3_uc002kxq.2_Missense_Mutation_p.Q1855H	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AGCAACAACAGCAGCTCTGTG	0.433													225	117					1.76002e-104	2.69831e-104	1	0	T	31326256	T	T	31326256	3	4	3	1	0	0	0	0	1	0	0	0	1070	962	34	4	6490	4	ASXL3	18	31326256	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	7285	31326256	46750992	333	713											
SYT4	6860	broad.mit.edu	37	chr18	40850486	40850486	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaacacttatatcttcaagGccctcacaaggaatatcaaa	16	10	4	11	0	5	0	4	0	1	0	5	1	5	1	1	2	1	0	1	2	8	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr18:40850486G>T	uc002law.2	-	4	1467	c.1098C>A	c.(1096-1098)GGC>GGA	p.G366G	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Silent_p.G348G|SYT4_uc010dnh.2_RNA	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	366	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TATCTTCAAGGCCCTCACAAG	0.433													54	35					1.67211e-32	2.25054e-32	1	0	T	40850486	T	T	40850486	2	4	3	1	0	0	0	0	0	0	0	1	15542	1190	42	4		4	SYT4	18	40850486	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	9524230	40850486	37226762	334	714											
CDC34	997	broad.mit.edu	37	chr19	532007	532007	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctgcaggaagagccggtcGagggattccgcgtgacactg	8	6	17	10	4	0	2	0	1	0	1	2	5	1	4	2	4	2	2	2	4	1	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:532007G>A	uc002lov.2	+	1	275	c.76G>A	c.(76-78)GAG>AAG	p.E26K		NM_004359	NP_004350	P49427	UB2R1_HUMAN	ubiquitin-conjugating enzyme Cdc34	26					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity				0		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGCCGGTCGAGGGATTCCG	0.672													3	3					0	0	0	0	A	532007	A	A	532007	3	1	3	1	0	0	0	0	1	0	0	0	3082	1059	37	1	78	1	CDC34	19	532007	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08		532007	58596976	335	715											
UBXN6	80700	broad.mit.edu	37	chr19	4454069	4454069	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggggctggctggttgggCttctctttgtgggccttttc	0	16	16	9	0	1	0	0	0	1	0	3	0	1	0	1	6	0	4	1	6	0	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:4454069C>A	uc002man.1	-	2	201	c.105G>T	c.(103-105)AAG>AAT	p.K35N	UBXN6_uc010dty.1_5'UTR|UBXN6_uc002mam.1_5'UTR	NM_025241	NP_079517	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	35						microtubule organizing center|nucleus	protein binding				0						GCTGGTTGGGCTTCTCTTTGT	0.657													143	34					3.36649e-63	5.07715e-63	1	0	A	4454069	A	A	4454069	3	1	3	1	0	0	0	0	1	0	0	0	16985	796	28	4	1260	4	UBXN6	19	4454069	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	3922062	4454069	54674914	336	716											
MUC16	94025	broad.mit.edu	37	chr19	9071035	9071035	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatttggttagtctgagagaTattaggagttgatgtggaaa	13	14	13	1	0	1	3	0	2	1	1	1	6	1	5	0	3	0	2	0	3	5	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:9071035T>C	uc002mkp.2	-	3	16615	c.16411A>G	c.(16411-16413)ATC>GTC	p.I5471V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5473	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCTGAGAGATATTAGGAGTT	0.507													140	21					0	0	0	0	C	9071035	C	C	9071035	3	2	3	1	0	0	0	0	1	0	0	0	10026	1406	49	5	27440	5	MUC16	19	9071035	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	4616966	9071035	50057948	337	717											
CYP4F12	66002	broad.mit.edu	37	chr19	15807871	15807871	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctttggctgcgggtggaGcccctgaatgtaagcttgca	6	10	16	9	1	0	1	0	1	0	0	0	2	0	2	2	4	4	5	2	4	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:15807871G>A	uc002nbl.2	+	13	1612	c.1551G>A	c.(1549-1551)GAG>GAA	p.E517E		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					TGCGGGTGGAGCCCCTGAATG	0.567													45	81					0	0	0	0	A	15807871	A	A	15807871	2	1	3	1	0	0	0	0	0	0	0	1	4204	962	34	4		4	CYP4F12	19	15807871	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	6736836	15807871	43321112	338	718											
ISYNA1	51477	broad.mit.edu	37	chr19	18545774	18545774	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatgcccattggcatcaccGgtgcagccattggtggcagc	8	8	13	12	1	1	1	1	0	0	1	1	1	1	1	3	4	4	3	3	4	0	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:18545774G>A	uc002njd.1	-	11	1676	c.1626C>T	c.(1624-1626)ACC>ACT	p.T542T	ISYNA1_uc002nja.1_Silent_p.T414T|ISYNA1_uc002njb.1_Silent_p.T460T|ISYNA1_uc002njc.1_Silent_p.T392T|ISYNA1_uc010xqh.1_Silent_p.T340T|ISYNA1_uc002nje.1_Silent_p.T488T|ISYNA1_uc002njf.1_Silent_p.T392T	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	542					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2						TGGCATCACCGGTGCAGCCAT	0.647													4	142					0	0	0	0	A	18545774	A	A	18545774	2	1	3	1	0	0	0	0	0	0	0	1	7906	1103	39	1		1	ISYNA1	19	18545774	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	2737903	18545774	40583209	339	719											
ZNF208	7757	broad.mit.edu	37	chr19	22155761	22155761	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacattcttcacatttgtagGgtttctctccagtatgaatt	9	17	6	9	0	3	1	1	1	2	0	5	1	4	1	1	1	0	3	1	1	3	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:22155761G>T	uc002nqp.2	-	5	1924	c.1775C>A	c.(1774-1776)CCC>CAC	p.P592H	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATTTGTAGGGTTTCTCTCC	0.383													47	99					4.33383e-22	5.35084e-22	1	0	T	22155761	T	T	22155761	3	4	3	1	0	0	0	0	1	0	0	0	17833	1232	43	4	1771	4	ZNF208	19	22155761	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	3609987	22155761	36973222	340	720											
ZNF98	148198	broad.mit.edu	37	chr19	22574982	22574982	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccttaccacattcttcaCatttgtagaatttctctcca	10	15	4	12	0	3	1	1	0	2	1	5	1	4	1	3	1	1	1	3	1	3	6			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:22574982C>T	uc002nqt.2	-	4	1177	c.1055G>A	c.(1054-1056)TGT>TAT	p.C352Y		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	352	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				ACATTCTTCACATTTGTAGAA	0.393													14	38					0	0	0	0	T	22574982	T	T	22574982	3	4	3	1	0	0	0	0	1	0	0	0	18270	478	17	4	667	4	ZNF98	19	22574982	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	419221	22574982	36554001	341	721											
ZNF99	7652	broad.mit.edu	37	chr19	22941189	22941189	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acattcttcacatttgcaagGtttctcttccatatgaatta	11	17	4	9	0	3	1	1	1	2	0	5	1	4	1	1	1	1	2	1	1	4	7			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:22941189G>T	uc010xrh.1	-	5	1249	c.1249C>A	c.(1249-1251)CCT>ACT	p.P417T		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CATTTGCAAGGTTTCTCTTCC	0.353													50	65					7.05377e-20	8.52714e-20	1	0	T	22941189	T	T	22941189	3	4	3	1	0	0	0	0	1	0	0	0	18271	1261	44	4	1875	4	ZNF99	19	22941189	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	366207	22941189	36187794	342	722											
CCNE1	898	broad.mit.edu	37	chr19	30312979	30312979	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggttgcatatctaaatgActtacatgaagtgctactgc	12	12	9	8	0	1	2	0	2	1	0	1	2	1	2	0	1	5	4	0	1	6	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:30312979A>G	uc002nsn.2	+	9	965	c.782A>G	c.(781-783)GAC>GGC	p.D261G	CCNE1_uc002nso.2_Missense_Mutation_p.D246G|CCNE1_uc002nsp.2_Missense_Mutation_p.D8G	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	261					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			TATCTAAATGACTTACATGAA	0.473													99	120					0	0	0	0	G	30312979	G	G	30312979	3	3	3	1	0	0	0	0	1	0	0	0	2935	275	10	5	812	5	CCNE1	19	30312979	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	7371790	30312979	28816004	343	723											
SIGLEC9	27180	broad.mit.edu	37	chr19	51631242	51631242	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtgactcagggggtggtcgGgggagctggagccacagccc	7	5	19	10	1	1	1	1	1	0	0	2	3	1	3	2	6	3	1	2	6	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:51631242G>T	uc002pvu.2	+	5	1119	c.1052G>T	c.(1051-1053)GGG>GTG	p.G351V	SIGLEC9_uc010yct.1_Missense_Mutation_p.G351V	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	351	Helical; (Potential).				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		GGGGTGGTCGGGGGAGCTGGA	0.552													83	233					1.46924e-35	2.0367e-35	1	0	T	51631242	T	T	51631242	3	4	3	1	0	0	0	0	1	0	0	0	14380	1232	43	4	1070	4	SIGLEC9	19	51631242	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	21318263	51631242	7497741	344	724											
ZNF845	91664	broad.mit.edu	37	chr19	53856114	53856114	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagtgtggcaaggccttcaGtcagaagtcatcccttacat	10	11	10	10	0	3	2	3	1	0	1	4	2	4	2	2	2	1	1	2	2	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:53856114G>T	uc010ydv.1	+	4	2303	c.2186G>T	c.(2185-2187)AGT>ATT	p.S729I	ZNF845_uc010ydw.1_Missense_Mutation_p.S729I	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	729	C2H2-type 19.			Missing (in Ref. 1; BAG58121).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGGCCTTCAGTCAGAAGTCA	0.418													55	102					5.39261e-20	6.53607e-20	1	0	T	53856114	T	T	53856114	3	4	3	1	0	0	0	0	1	0	0	0	18258	1029	36	4	2196	4	ZNF845	19	53856114	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	2224872	53856114	5272869	345	725											
LILRB2	10288	broad.mit.edu	37	chr19	54782747	54782747	+	Frame_Shift_Del	DEL	C	-	-																															caccgtagcatctgtactggCccccgtaggagcggctcaca																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:54782747delC	uc002qfb.2	-	6	1141	c.875delG	c.(874-876)GGCfs	p.G292fs	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Frame_Shift_Del_p.G292fs|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Frame_Shift_Del_p.G292fs|LILRB2_uc010yet.1_Frame_Shift_Del_p.G176fs|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	292	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCTGTACTGGCCCCCGTAGGA	0.677													---	---	---								-	54782747	-	-	54782747	7	5	3	1	0	1	0	1	0	0	0	0	8832	739	26	0	957	0	LILRB2	19	54782747	Frame_Shift_Del	DEL	C	TCGA-BA-4076-01A-01D-1434-08	926633	54782747	4346236	346	726											
LAIR1	3903	broad.mit.edu	37	chr19	54868568	54868568	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgttgtccgacggcctctgCgtgggtcctgggagggagga	4	9	18	10	3	1	0	0	0	1	0	3	4	3	3	3	5	1	1	3	5	0	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:54868568C>T	uc002qfk.1	-	5	733	c.423G>A	c.(421-423)ACG>ACA	p.T141T	LAIR1_uc002qfl.1_Silent_p.T124T|LAIR1_uc002qfm.1_Silent_p.T140T|LAIR1_uc002qfn.1_Silent_p.T123T|LAIR1_uc010yex.1_Silent_p.T134T|LAIR1_uc002qfo.2_Silent_p.T123T	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like	141	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity			ovary(4)	4	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		ACGGCCTCTGCGTGGGTCCTG	0.522													14	19					0	0	0	0	T	54868568	T	T	54868568	2	4	3	1	0	0	0	0	0	0	0	1	8642	755	27	1		1	LAIR1	19	54868568	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	85821	54868568	4260415	347	727											
LILRA2	11027	broad.mit.edu	37	chr19	55087544	55087544	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacccctacctgctgtctcTccccagtgaccccctggagc	6	8	7	20	0	1	1	0	1	1	0	3	2	2	2	7	1	4	1	7	1	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:55087544T>A	uc002qgg.3	+	6	1312	c.1223T>A	c.(1222-1224)CTC>CAC	p.L408H	LILRA2_uc010ern.2_Missense_Mutation_p.L408H|LILRA2_uc002qgf.2_Missense_Mutation_p.L408H|LILRA2_uc010yfe.1_Missense_Mutation_p.L408H|LILRA2_uc010yff.1_Missense_Mutation_p.L396H|LILRA2_uc010ero.2_Missense_Mutation_p.L396H|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	408	Ig-like C2-type 4.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CTGCTGTCTCTCCCCAGTGAC	0.622													79	114					0	0	0	0	A	55087544	A	A	55087544	3	1	3	1	0	0	0	0	1	0	0	0	8826	1551	54	5	1245	5	LILRA2	19	55087544	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	218976	55087544	4041439	348	728											
LILRA1	11024	broad.mit.edu	37	chr19	55106644	55106644	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgtgaccctccattgtgtCtcacaggtggcatttggcag	8	11	11	11	1	1	1	1	1	1	0	3	1	2	1	2	3	1	2	2	3	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:55106644C>A	uc002qgh.1	+	5	620	c.438C>A	c.(436-438)GTC>GTA	p.V146V	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Silent_p.V146V	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	146	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		TCCATTGTGTCTCACAGGTGG	0.567													79	110					1.39921e-30	1.85626e-30	1	0	A	55106644	A	A	55106644	2	1	3	1	0	0	0	0	0	0	0	1	8825	900	32	2		2	LILRA1	19	55106644	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	19100	55106644	4022339	349	729											
KIR3DL1	3811	broad.mit.edu	37	chr19	55341657	55341657	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctcagaggcccaagacacCccctacagataccatcttgt	11	9	6	15	0	2	3	1	0	2	3	3	3	2	3	4	1	2	0	4	1	3	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:55341657C>A	uc002qhk.3	+	9	1325	c.1262C>A	c.(1261-1263)CCC>CAC	p.P421H	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.P346H|KIR3DL1_uc010esf.2_Missense_Mutation_p.P326H|KIR3DL1_uc010yfo.1_Missense_Mutation_p.P363H|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_5'Flank|KIR2DS4_uc002qhm.1_5'Flank	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	421	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		CCCAAGACACCCCCTACAGAT	0.512													196	35					2.91701e-67	4.41364e-67	1	0	A	55341657	A	A	55341657	3	1	3	1	0	0	0	0	1	0	0	0	8359	623	22	4	1296	4	KIR3DL1	19	55341657	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	235013	55341657	3787326	350	730											
NLRP11	204801	broad.mit.edu	37	chr19	56300317	56300317	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggcaagagatcgacagcagGcactggttaacatgcactct	13	7	11	10	1	1	1	0	0	1	1	2	3	1	1	0	3	3	5	0	3	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:56300317G>C	uc010ygf.1	-	11	3422	c.2711C>G	c.(2710-2712)GCC>GGC	p.A904G	NLRP11_uc002qlz.2_Missense_Mutation_p.A751G|NLRP11_uc002qmb.2_Missense_Mutation_p.A805G|NLRP11_uc002qmc.2_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	904							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TCGACAGCAGGCACTGGTTAA	0.458													21	53					0	0	0	0	C	56300317	C	C	56300317	3	2	3	1	0	0	0	0	1	0	0	0	10527	1203	42	4	398	4	NLRP11	19	56300317	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	958660	56300317	2828666	351	731											
NLRP4	147945	broad.mit.edu	37	chr19	56390176	56390176	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaggttggaagaatgtgggTtaacgagcacctgctgtaag	11	9	15	6	1	0	1	0	0	0	1	0	3	0	2	1	3	3	6	1	3	4	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:56390176T>A	uc002qmd.3	+	9	3135	c.2713T>A	c.(2713-2715)TTA>ATA	p.L905I	NLRP4_uc002qmf.2_Missense_Mutation_p.L830I|NLRP4_uc010etf.2_Missense_Mutation_p.L680I	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	905							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AGAATGTGGGTTAACGAGCAC	0.532													17	20					0	0	0	0	A	56390176	A	A	56390176	3	1	3	1	0	0	0	0	1	0	0	0	10533	1722	60	5	2743	5	NLRP4	19	56390176	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	89859	56390176	2738807	352	732											
NLRP5	126206	broad.mit.edu	37	chr19	56539074	56539074	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtggtgggggagagcgtcgCccccttcaaccaaacgctca	8	6	13	14	4	2	1	2	0	0	1	3	2	2	1	3	3	3	1	3	3	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:56539074C>A	uc002qmj.2	+	7	1475	c.1475C>A	c.(1474-1476)GCC>GAC	p.A492D	NLRP5_uc002qmi.2_Missense_Mutation_p.A473D	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	492	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GAGAGCGTCGCCCCCTTCAAC	0.632													26	32					1.42536e-11	1.56384e-11	1	0	A	56539074	A	A	56539074	3	1	3	1	0	0	0	0	1	0	0	0	10534	739	26	4	1501	4	NLRP5	19	56539074	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	148898	56539074	2589909	353	733											
ZIM3	114026	broad.mit.edu	37	chr19	57647166	57647166	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaggtgactttgaaggcgtGactttgaactgaataacttt	11	14	10	6	1	1	5	1	5	0	0	1	5	1	5	0	2	2	0	0	2	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:57647166G>C	uc002qnz.1	-	5	925	c.539C>G	c.(538-540)TCA>TGA	p.S180*		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	180	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTGAAGGCGTGACTTTGAACT	0.398													232	171					0	0	0	0	C	57647166	C	C	57647166	4	2	3	1	0	0	0	0	0	1	0	0	17752	1294	45	2	883	2	ZIM3	19	57647166	Nonsense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	1108092	57647166	1481817	354	734											
ZNF264	9422	broad.mit.edu	37	chr19	57723577	57723577	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcataccggggagaagccctAtgagtgcagtgaatgtggga	11	8	15	7	1	1	3	1	2	0	1	1	5	1	4	2	3	3	1	2	3	4	2	rs139216855		TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr19:57723577A>C	uc002qob.2	+	4	1525	c.1112A>C	c.(1111-1113)TAT>TCT	p.Y371S		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	371	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		GAGAAGCCCTATGAGTGCAGT	0.517													52	138					0	0	0	0	C	57723577	C	C	57723577	3	2	3	1	0	0	0	0	1	0	0	0	17871	449	16	5	1126	5	ZNF264	19	57723577	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	76411	57723577	1405406	355	735											
SLC24A3	57419	broad.mit.edu	37	chr20	19566110	19566110	+	Frame_Shift_Del	DEL	G	-	-																															ttcatcaccaaaggcgatgtGggagttggcaccatcgtggg																										TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr20:19566110delG	uc002wrl.2	+	6	731	c.534delG	c.(532-534)GTGfs	p.V178fs		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	178	Extracellular (Potential).|Alpha-1.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						AAGGCGATGTGGGAGTTGGCA	0.547													---	---	---								-	19566110	-	-	19566110	7	5	3	1	0	1	0	1	0	0	0	0	14531	1335	47	0	556	0	SLC24A3	20	19566110	Frame_Shift_Del	DEL	G	TCGA-BA-4076-01A-01D-1434-08		19566110	43459410	356	736											
EIF6	3692	broad.mit.edu	37	chr20	33867551	33867551	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcggttcacagtccccgcCtgccaagggatgggctcaat	7	8	11	15	2	2	0	2	0	0	0	4	1	3	1	5	3	1	2	5	3	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr20:33867551C>T	uc002xbv.1	-	5	763	c.547_splice	c.e5-1	p.A183_splice	EDEM2_uc010zuv.1_5'Flank|EIF6_uc002xbx.1_Splice_Site_p.A183_splice|EIF6_uc002xbz.1_Splice_Site_p.A164_splice|EIF6_uc002xby.1_Splice_Site	NM_181468	NP_852133	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6						mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CAGTCCCCGCCTGCCAAGGGA	0.587													36	50					0	0	0	0	T	33867551	T	T	33867551	5	4	3	1	0	0	0	0	0	0	1	0	5069	695	24	4	199	4	EIF6	20	33867551	Splice_Site	SNP	C	TCGA-BA-4076-01A-01D-1434-08	14301441	33867551	29157969	357	737											
C20orf135	140701	broad.mit.edu	37	chr20	62493607	62493607	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caccgcctgcacttcccgccCgcgcacctggtggtctacgg	4	7	11	19	5	1	0	0	0	1	0	2	0	2	0	5	3	2	2	5	3	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr20:62493607C>G	uc002ygx.1	+	1	1042	c.714C>G	c.(712-714)CCC>CCG	p.P238P	TPD52L2_uc002ygy.2_5'Flank|TPD52L2_uc002ygz.2_5'Flank|TPD52L2_uc002yha.2_5'Flank|TPD52L2_uc002yhb.2_5'Flank|TPD52L2_uc002yhc.2_5'Flank|TPD52L2_uc002yhd.2_5'Flank|TPD52L2_uc011abk.1_5'Flank|TPD52L2_uc011abl.1_5'Flank	NM_080622	NP_542189	Q9H3Z7	ABHGB_HUMAN	hypothetical protein LOC140701	238							hydrolase activity				0	all_cancers(38;1.77e-12)|all_epithelial(29;3.12e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					ACTTCCCGCCCGCGCACCTGG	0.687													10	19					0	0	0	0	G	62493607	G	G	62493607	2	3	3	1	0	0	0	0	0	0	0	1	2098	639	23	3		3	C20orf135	20	62493607	Silent	SNP	C	TCGA-BA-4076-01A-01D-1434-08	28626056	62493607	531913	358	738											
KRTAP20-2	337976	broad.mit.edu	37	chr21	32007617	32007617	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caactactatggtggtctgcGttatggctatggagtcctgg	7	13	13	8	1	1	0	0	0	1	0	2	1	2	1	1	5	3	2	1	5	5	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr21:32007617G>A	uc011adg.1	+	1	35	c.35G>A	c.(34-36)CGT>CAT	p.R12H		NM_181616	NP_853647	Q3LI61	KR202_HUMAN	keratin associated protein 20-2	12						intermediate filament				central_nervous_system(1)	1						GGTGGTCTGCGTTATGGCTAT	0.522													50	74					0	0	0	0	A	32007617	A	A	32007617	3	1	3	1	0	0	0	0	1	0	0	0	8576	1145	40	1	37	1	KRTAP20-2	21	32007617	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08		32007617	16122278	359	739											
SYNJ1	8867	broad.mit.edu	37	chr21	34011284	34011284	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcgaggtggtggttgtggTggggtttccaaatttggctg	4	15	17	5	1	0	0	0	0	0	0	2	1	1	0	1	7	0	3	1	7	1	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr21:34011284T>A	uc002yqh.2	-	31	3966	c.3966A>T	c.(3964-3966)CCA>CCT	p.P1322P	SYNJ1_uc011ads.1_Silent_p.P1236P|SYNJ1_uc002yqf.2_Silent_p.P1267P|SYNJ1_uc002yqg.2_Silent_p.P1236P|SYNJ1_uc002yqi.2_Silent_p.P1322P|SYNJ1_uc002yqe.3_5'UTR	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1283	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						GTGGTTGTGGTGGGGTTTCCA	0.507													142	238					0	0	0	0	A	34011284	A	A	34011284	2	1	3	1	0	0	0	0	0	0	0	1	15518	1683	59	5		5	SYNJ1	21	34011284	Silent	SNP	T	TCGA-BA-4076-01A-01D-1434-08	2003667	34011284	14118611	360	740											
KRTAP12-2	353323	broad.mit.edu	37	chr21	46086539	46086539	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacacaatgggcctgcagcTcacaggcacacacacagaag	15	3	9	14	0	1	1	1	0	0	1	1	1	1	1	1	2	2	3	1	2	2	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr21:46086539T>C	uc002zfu.2	-	1	306	c.265A>G	c.(265-267)AGC>GGC	p.S89G	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181684	NP_859012	P59991	KR122_HUMAN	keratin associated protein 12-2	89	14.|23 X 5 AA approximate repeats.					keratin filament					0						GGCCTGCAGCTCACAGGCACA	0.632													31	44					0	0	0	0	C	46086539	C	C	46086539	3	2	3	1	0	0	0	0	1	0	0	0	8558	1551	54	5	179	5	KRTAP12-2	21	46086539	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	12075255	46086539	2043356	361	741											
PCNT	5116	broad.mit.edu	37	chr21	47821491	47821491	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggtgttaaagaaacagcaGatgagtagcttgcttctggc	12	10	13	6	0	1	3	0	1	1	2	1	4	1	3	0	2	4	5	0	2	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr21:47821491G>A	uc002zji.3	+	26	4925	c.4818G>A	c.(4816-4818)CAG>CAA	p.Q1606Q	PCNT_uc002zjj.2_Silent_p.Q1488Q	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1606	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AGAAACAGCAGATGAGTAGCT	0.453													51	93					0	0	0	0	A	47821491	A	A	47821491	2	1	3	1	0	0	0	0	0	0	0	1	11644	933	33	2		2	PCNT	21	47821491	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	1734952	47821491	308404	362	742											
DIP2A	23181	broad.mit.edu	37	chr21	47910617	47910617	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcccaccgcctcgagggatGagcgcttccggtcaggtagg	6	6	16	13	4	1	1	1	1	0	0	3	3	2	2	4	5	1	2	4	5	1	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr21:47910617G>A	uc002zjo.2	+	3	451	c.268G>A	c.(268-270)GAG>AAG	p.E90K	DIP2A_uc011afy.1_Intron|DIP2A_uc011afz.1_Missense_Mutation_p.E90K|DIP2A_uc002zjl.2_Missense_Mutation_p.E90K|DIP2A_uc002zjm.2_Missense_Mutation_p.E90K|DIP2A_uc010gql.2_Missense_Mutation_p.E90K|DIP2A_uc002zjn.2_Missense_Mutation_p.E90K	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	90					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CTCGAGGGATGAGCGCTTCCG	0.592													6	7					0	0	0	0	A	47910617	A	A	47910617	3	1	3	1	0	0	0	0	1	0	0	0	4549	1291	45	2	278	2	DIP2A	21	47910617	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	89126	47910617	219278	363	743											
C22orf39	128977	broad.mit.edu	37	chr22	19431847	19431847	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggaggggggctctgcctcgGggcccacaccaggatgtgct	5	7	17	12	1	1	0	0	0	1	0	2	2	1	2	3	7	2	2	3	7	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr22:19431847G>C	uc002zpk.1	-	3	268	c.259C>G	c.(259-261)CCG>GCG	p.P87A	HIRA_uc010gro.1_Intron|HIRA_uc010grp.2_Intron|C22orf39_uc002zpi.2_Intron|C22orf39_uc002zpj.2_5'Flank	NM_173793	NP_776154	Q6P5X5	CV039_HUMAN	hypothetical protein LOC128977	87											0	Colorectal(54;0.0993)					CTCTGCCTCGGGGCCCACACC	0.622													26	44					0	0	0	0	C	19431847	C	C	19431847	3	2	3	1	0	0	0	0	1	0	0	0	2157	1232	43	4	117	4	C22orf39	22	19431847	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08		19431847	31872719	364	744											
CDC45	8318	broad.mit.edu	37	chr22	19471512	19471512	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcagagccttctgagaagcGcacacggttagaagaggtga	12	7	14	8	2	2	5	1	2	1	4	2	6	2	5	1	2	2	2	1	2	3	2			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr22:19471512G>A	uc002zpr.2	+	5	546	c.470G>A	c.(469-471)CGC>CAC	p.R157H	CDC45_uc011agz.1_Missense_Mutation_p.R152H|CDC45_uc011aha.1_Missense_Mutation_p.R157H|CDC45_uc002zps.2_Missense_Mutation_p.R157H|CDC45_uc002zpt.2_Missense_Mutation_p.R111H	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	157					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						TCTGAGAAGCGCACACGGTTA	0.517													5	113					0	0	0	0	A	19471512	A	A	19471512	3	1	3	1	0	0	0	0	1	0	0	0	3096	1087	38	1	488	1	CDC45	22	19471512	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	39665	19471512	31833054	365	745											
MYO18B	84700	broad.mit.edu	37	chr22	26423401	26423401	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaccgttcctttctctcgggGatcaagaccattttgaagaa	11	12	8	10	2	2	3	1	1	1	2	5	4	3	4	3	2	1	1	3	2	4	4			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr22:26423401G>C	uc003abz.1	+	43	7711	c.7461G>C	c.(7459-7461)GGG>GGC	p.G2487G	MYO18B_uc003aca.1_Silent_p.G2368G|MYO18B_uc010guy.1_Silent_p.G2369G|MYO18B_uc010guz.1_Silent_p.G2367G|MYO18B_uc011aka.1_Silent_p.G1641G|MYO18B_uc011akb.1_Silent_p.G2000G|MYO18B_uc010gva.1_Silent_p.G470G|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2487						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TTCTCTCGGGGATCAAGACCA	0.547													20	34					0	0	0	0	C	26423401	C	C	26423401	2	2	3	1	0	0	0	0	0	0	0	1	10119	1161	41	2		2	MYO18B	22	26423401	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	6951889	26423401	24881165	366	746											
MCM5	4174	broad.mit.edu	37	chr22	35804507	35804507	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agctgcaggagctgcctgatGcagtcccccacggggagatg	8	6	15	12	1	0	2	0	1	0	1	1	4	1	3	3	3	5	4	3	3	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr22:35804507G>T	uc003anu.3	+	6	797	c.703G>T	c.(703-705)GCA>TCA	p.A235S	MCM5_uc010gwr.2_Missense_Mutation_p.A44S|MCM5_uc003anv.3_Missense_Mutation_p.A192S|MCM5_uc010gws.1_RNA|MCM5_uc003anw.1_5'Flank	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	235					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						GCTGCCTGATGCAGTCCCCCA	0.617													42	48					9.84934e-19	1.17532e-18	1	0	T	35804507	T	T	35804507	3	4	3	1	0	0	0	0	1	0	0	0	9443	1319	46	4	721	4	MCM5	22	35804507	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	9381106	35804507	15500059	367	747											
SSTR3	6753	broad.mit.edu	37	chr22	37603211	37603211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcccgaagaagcccagtgcgGccgtgtagatgatgaagccg	10	5	15	11	4	0	4	0	2	0	2	0	5	0	4	4	1	3	1	4	1	4	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr22:37603211G>A	uc003ara.2	-	2	694	c.632C>T	c.(631-633)GCC>GTC	p.A211V	SSTR3_uc003arb.2_Missense_Mutation_p.A211V	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	211	Helical; Name=5; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						GCCCAGTGCGGCCGTGTAGAT	0.692													18	32					0	0	0	0	A	37603211	A	A	37603211	3	1	3	1	0	0	0	0	1	0	0	0	15265	1203	42	4	628	4	SSTR3	22	37603211	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	1798704	37603211	13701355	368	748											
TRIOBP	11078	broad.mit.edu	37	chr22	38119740	38119740	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acgatcccagagcctcctctCccaacagaaccactcaacga	13	5	5	18	2	2	2	1	0	1	2	5	4	4	2	5	0	4	0	5	0	3	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr22:38119740C>G	uc003atr.2	+	7	1448	c.1177C>G	c.(1177-1179)CCC>GCC	p.P393A	TRIOBP_uc003atu.2_Missense_Mutation_p.P221A|TRIOBP_uc003atq.1_Missense_Mutation_p.P393A|TRIOBP_uc003ats.1_Missense_Mutation_p.P221A	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	393					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					AGCCTCCTCTCCCAACAGAAC	0.562													96	102					0	0	0	0	G	38119740	G	G	38119740	3	3	3	1	0	0	0	0	1	0	0	0	16620	855	30	2	1195	2	TRIOBP	22	38119740	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	516529	38119740	13184826	369	749											
EP300	2033	broad.mit.edu	37	chr22	41574850	41574850	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctttctcagcttgctagcAatccaggcatggcaaacctc	9	11	8	13	0	1	0	1	0	1	0	4	0	2	0	2	2	5	6	2	2	3	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chr22:41574850A>C	uc003azl.3	+	31	7530	c.7135A>C	c.(7135-7137)AAT>CAT	p.N2379H		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	2379					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GCTTGCTAGCAATCCAGGCAT	0.537			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				43	51					0	0	0	0	C	41574850	C	C	41574850	3	2	3	1	0	0	0	0	1	0	0	0	5172	130	5	5	7257	5	EP300	22	41574850	Missense_Mutation	SNP	A	TCGA-BA-4076-01A-01D-1434-08	3455110	41574850	9729716	370	750											
ASMT	438	broad.mit.edu	37	chrX	1748783	1748783	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcgtcaacgggagaagcgtGctgaccgcctttgacctgtc	8	8	13	12	4	1	3	1	2	0	1	2	4	1	3	3	1	4	1	3	1	2	1			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:1748783G>A	uc004cqd.2	+	6	658	c.513G>A	c.(511-513)GTG>GTA	p.V171V	ASMT_uc010ncy.2_Silent_p.V171V|ASMT_uc004cqe.2_Silent_p.V171V	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	171					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGAGAAGCGTGCTGACCGCCT	0.552													110	156					0	0	0	0	A	1748783	A	A	1748783	2	1	3	1	0	0	0	0	0	0	0	1	1047	1306	46	4		4	ASMT	23	1748783	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08		1748783	153521777	371	751											
FRMPD4	9758	broad.mit.edu	37	chrX	12736646	12736646	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcagtgcctgtgccacacCcgtggagtcgccgctctgcc	4	8	13	16	3	1	0	0	0	1	0	2	1	1	1	5	2	3	2	5	2	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:12736646C>T	uc004cuz.1	+	16	4207	c.3701C>T	c.(3700-3702)CCC>CTC	p.P1234L	FRMPD4_uc011mij.1_Missense_Mutation_p.P1226L	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1234					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TGTGCCACACCCGTGGAGTCG	0.597													92	23					0	0	0	0	T	12736646	T	T	12736646	3	4	3	1	0	0	0	0	1	0	0	0	6093	623	22	4	3763	4	FRMPD4	23	12736646	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	10987863	12736646	142533914	372	752											
SCML2	10389	broad.mit.edu	37	chrX	18338540	18338540	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggatgtattcatctggtacCctgttttataaaataaatta	14	16	6	5	0	2	0	1	0	1	0	2	1	2	1	1	2	1	3	1	2	8	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:18338540C>G	uc004cyl.2	-	6	555	c.398G>C	c.(397-399)GGG>GCG	p.G133A	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.G133A|SCML2_uc011miz.1_Missense_Mutation_p.G67A	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	133					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					CATCTGGTACCCTGTTTTATA	0.353													56	10					0	0	0	0	G	18338540	G	G	18338540	3	3	3	1	0	0	0	0	1	0	0	0	13975	637	22	4	1744	4	SCML2	23	18338540	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5601894	18338540	136932020	373	753											
FAM47B	170062	broad.mit.edu	37	chrX	34962248	34962248	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaccaagaccggagcgtccCatctaaaagaactgtttcag	13	8	8	12	2	2	2	1	0	1	2	3	3	3	3	3	1	3	1	3	1	5	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:34962248C>A	uc004ddi.1	+	1	1318	c.1300C>A	c.(1300-1302)CAT>AAT	p.H434N		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	434										ovary(3)|breast(1)	4						CGGAGCGTCCCATCTAAAAGA	0.517													44	14					8.20599e-20	9.8685e-20	1	0	A	34962248	A	A	34962248	3	1	3	1	0	0	0	0	1	0	0	0	5602	594	21	4	1302	4	FAM47B	23	34962248	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	16623708	34962248	120308312	374	754											
DGKK	139189	broad.mit.edu	37	chrX	50121610	50121610	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgatgcaggttgatgataCgggacattgccatctgcaca	11	10	12	8	1	1	3	0	3	1	0	1	5	1	4	1	2	4	3	1	2	1	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:50121610C>T	uc010njr.1	-	21	3002	c.2942G>A	c.(2941-2943)CGT>CAT	p.R981H		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	981					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					GTTGATGATACGGGACATTGC	0.542													10	5					0	0	0	0	T	50121610	T	T	50121610	3	4	3	1	0	0	0	0	1	0	0	0	4494	536	19	1	904	1	DGKK	23	50121610	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	15159362	50121610	105148950	375	755											
DGKK	139189	broad.mit.edu	37	chrX	50127734	50127734	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacggcgtcgtgggcttgtCtggttaatatcttctgggtc	4	16	13	8	3	3	0	0	0	3	0	5	0	3	0	0	4	1	2	0	4	3	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:50127734C>G	uc010njr.1	-	16	2496	c.2436G>C	c.(2434-2436)CAG>CAC	p.Q812H		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	812					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					GTGGGCTTGTCTGGTTAATAT	0.388													113	25					0	0	0	0	G	50127734	G	G	50127734	3	3	3	1	0	0	0	0	1	0	0	0	4494	912	32	2	1430	2	DGKK	23	50127734	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	6124	50127734	105142826	376	756											
ATP7A	538	broad.mit.edu	37	chrX	77294477	77294477	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgtattagtagcagttGatggtaaggttttccataag	10	15	11	5	0	0	1	0	1	0	0	1	1	1	1	1	2	2	7	1	2	5	8			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:77294477G>T	uc004ecx.3	+	18	3815	c.3655G>T	c.(3655-3657)GAT>TAT	p.D1219Y		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1219	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						AGTAGCAGTTGATGGTAAGGT	0.323													62	18					2.34445e-45	3.38156e-45	1	0	T	77294477	T	T	77294477	3	4	3	1	0	0	0	0	1	0	0	0	1192	1290	45	2	3721	2	ATP7A	23	77294477	Missense_Mutation	SNP	G	TCGA-BA-4076-01A-01D-1434-08	27166743	77294477	77976083	377	757											
POU3F4	5456	broad.mit.edu	37	chrX	82763828	82763828	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacagagcctgcacccggtgCtccgagagcccccggatcac	8	4	11	18	3	1	2	1	0	0	2	2	4	2	3	5	2	4	2	5	2	0	0			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:82763828C>A	uc004eeg.2	+	1	560	c.496C>A	c.(496-498)CTC>ATC	p.L166I		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	166					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCACCCGGTGCTCCGAGAGCC	0.647													6	1					0.00307968	0.00315463	1	0	A	82763828	A	A	82763828	3	1	3	1	0	0	0	0	1	0	0	0	12332	797	28	4	498	4	POU3F4	23	82763828	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5469351	82763828	72506732	378	758											
GPRASP2	114928	broad.mit.edu	37	chrX	101970808	101970808	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagatgagttctataagcaGtcctgggttttgcctggaga	10	12	13	6	0	1	3	0	1	1	2	2	5	2	3	2	2	2	3	2	2	3	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:101970808G>A	uc004ejk.2	+	4	2345	c.1011G>A	c.(1009-1011)CAG>CAA	p.Q337Q	GPRASP2_uc004ejl.2_Silent_p.Q337Q|GPRASP2_uc004ejm.2_Silent_p.Q337Q|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	337						cytoplasm	protein binding			ovary(1)	1						TCTATAAGCAGTCCTGGGTTT	0.458													71	19					0	0	0	0	A	101970808	A	A	101970808	2	1	3	1	0	0	0	0	0	0	0	1	6762	1020	36	4		4	GPRASP2	23	101970808	Silent	SNP	G	TCGA-BA-4076-01A-01D-1434-08	19206980	101970808	53299752	379	759											
COL4A5	1287	broad.mit.edu	37	chrX	107930715	107930715	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttatttcgtggaaataggtaCccgtggtttggatggtcccc	7	14	12	8	2	0	0	0	0	0	0	2	2	1	2	3	5	1	2	3	5	4	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:107930715C>T	uc004enz.1	+	48	4521	c.4319C>T	c.(4318-4320)ACC>ATC	p.T1440I	COL4A5_uc011mso.1_Missense_Mutation_p.T1437I|COL4A5_uc011msp.1_Missense_Mutation_p.T116I	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1434	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GAAATAGGTACCCGTGGTTTG	0.443									Alport_syndrome_with_Diffuse_Leiomyomatosis				99	25					0	0	0	0	T	107930715	T	T	107930715	3	4	3	1	0	0	0	0	1	0	0	0	3709	507	18	4	4498	4	COL4A5	23	107930715	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	5959907	107930715	47339845	380	760											
CD40LG	959	broad.mit.edu	37	chrX	135741549	135741549	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccatggcactggcttcaCgtcctttggcttactcaaac	8	11	9	13	1	2	0	2	0	0	0	3	1	3	0	2	3	3	3	2	3	2	3			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:135741549C>A	uc004faa.2	+	5	833	c.761C>A	c.(760-762)ACG>AAG	p.T254K	CD40LG_uc010nsd.2_Missense_Mutation_p.T233K	NM_000074	NP_000065	P29965	CD40L_HUMAN	CD40 ligand	254	Extracellular (Potential).		T -> M (in HIGM1).		anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	ACTGGCTTCACGTCCTTTGGC	0.507									Immune_Deficiency_with_Hyper-IgM				66	15					9.4991e-31	1.26382e-30	1	0	A	135741549	A	A	135741549	3	1	3	1	0	0	0	0	1	0	0	0	3031	536	19	3	779	3	CD40LG	23	135741549	Missense_Mutation	SNP	C	TCGA-BA-4076-01A-01D-1434-08	27810834	135741549	19529011	381	761											
MAGEC1	9947	broad.mit.edu	37	chrX	140993927	140993927	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcctcctccactttacTgagtcttttccagagtttct	5	17	4	15	0	2	2	0	1	2	1	7	2	7	2	5	0	1	1	5	0	1	5			TCGA-BA-4076-01A-01D-1434-08	TCGA-BA-4076-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	93dda6a6-907d-4dc2-9391-36dd09c767c6	d6c21ecb-1cb2-45fd-84c0-186287708883	g.chrX:140993927T>A	uc004fbt.2	+	4	1023	c.737T>A	c.(736-738)CTG>CAG	p.L246Q	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	246							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCACTTTACTGAGTCTTTTC	0.498										HNSCC(15;0.026)			207	38					0	0	0	0	A	140993927	A	A	140993927	3	1	3	1	0	0	0	0	1	0	0	0	9233	1580	55	5	743	5	MAGEC1	23	140993927	Missense_Mutation	SNP	T	TCGA-BA-4076-01A-01D-1434-08	5252378	140993927	14276633	382	762											
NOC2L	26155	broad.mit.edu	37	chr1	892498	892498	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctccagcacatctggcaggGagtggaacggcccctcttcc	7	7	11	16	1	2	0	0	0	2	0	4	2	4	2	5	4	2	2	5	4	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:892498G>A	uc001abz.3	-	3	394	c.335C>T	c.(334-336)TCC>TTC	p.S112F	NOC2L_uc001aby.3_5'UTR|NOC2L_uc009vjq.2_Missense_Mutation_p.S112F	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	112						nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		ATCTGGCAGGGAGTGGAACGG	0.582													66	389					0	0	0	0	A	892498	A	A	892498	3	1	4	1	0	0	0	0	1	0	0	0	10567	1174	41	2	1982	2	NOC2L	1	892498	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08		892498	248358123	1	763											
ARHGEF16	27237	broad.mit.edu	37	chr1	3394440	3394440	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cccggctctgtccccccagtCcctcccactgatctctgcct	3	10	6	22	1	2	1	0	1	2	0	6	1	5	1	7	1	1	1	7	1	0	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:3394440C>G	uc001akg.3	+	11	1723	c.1475C>G	c.(1474-1476)TCC>TGC	p.S492C	ARHGEF16_uc001aki.2_Missense_Mutation_p.S204C|ARHGEF16_uc001akj.2_Missense_Mutation_p.S204C|ARHGEF16_uc010nzh.1_Missense_Mutation_p.S196C	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	492					activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		TCCCCCCAGTCCCTCCCACTG	0.637													15	79					0	0	0	0	G	3394440	G	G	3394440	3	3	4	1	0	0	0	0	1	0	0	0	899	869	30	2	1513	2	ARHGEF16	1	3394440	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2501942	3394440	245856181	2	764											
AJAP1	55966	broad.mit.edu	37	chr1	4772109	4772109	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgcggtcgccgccccggcCgccccggctgtggagtttta	2	7	15	17	7	0	0	0	0	0	0	1	1	0	1	7	4	0	2	7	4	1	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:4772109C>T	uc001alm.1	+	2	560	c.179C>T	c.(178-180)CCG>CTG	p.P60L	AJAP1_uc001aln.2_Missense_Mutation_p.P60L	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	60	Extracellular (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		ccgccccggccgccccggcTG	0.592													25	75					0	0	0	0	T	4772109	T	T	4772109	3	4	4	1	0	0	0	0	1	0	0	0	438	652	23	1	185	1	AJAP1	1	4772109	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1377669	4772109	244478512	3	765											
EPHA2	1969	broad.mit.edu	37	chr1	16458218	16458218	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagggcaagggcacccacctCgtggttggacaactcccagt	9	6	13	13	1	0	0	0	0	0	0	2	2	1	1	3	4	1	3	3	4	2	1	rs2291806		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:16458218C>T	uc001aya.1	-	14	2610	c.2473G>A	c.(2473-2475)GAG>AAG	p.E825K		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	825	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.|Cytoplasmic (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GCACCCACCTCGTGGTTGGAC	0.587													11	87					0	0	0	0	T	16458218	T	T	16458218	3	4	4	1	0	0	0	0	1	0	0	0	5191	893	31	1	473	1	EPHA2	1	16458218	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	11686109	16458218	232792403	4	766											
HSPG2	3339	broad.mit.edu	37	chr1	22158995	22158995	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgggggtctcaccggaactCgggccttccccccacgaggc	5	6	13	17	3	1	0	1	0	1	0	4	2	2	1	5	5	1	0	5	5	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:22158995C>T	uc001bfj.2	-	81	11240	c.11200G>A	c.(11200-11202)GAG>AAG	p.E3734K	HSPG2_uc001bfi.2_5'Flank|HSPG2_uc009vqd.2_Missense_Mutation_p.E3735K	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3734	Laminin G-like 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CACCGGAACTCGGGCCTTCCC	0.632													16	103					0	0	0	0	T	22158995	T	T	22158995	3	4	4	1	0	0	0	0	1	0	0	0	7469	893	31	1	2043	1	HSPG2	1	22158995	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	5700777	22158995	227091626	5	767											
MYOM3	127294	broad.mit.edu	37	chr1	24432564	24432564	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcctcctggaccttctcctCtgtctggaggcgggaagagg	5	9	15	12	1	3	1	0	0	3	1	5	4	4	4	4	6	0	0	4	6	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:24432564C>G	uc001bin.3	-	5	569	c.406G>C	c.(406-408)GAG>CAG	p.E136Q	MYOM3_uc001bio.2_Missense_Mutation_p.E136Q|MYOM3_uc001bip.1_5'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	136	Potential.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		ACCTTCTCCTCTGTCTGGAGG	0.617													7	36					0	0	0	0	G	24432564	G	G	24432564	3	3	4	1	0	0	0	0	1	0	0	0	10146	922	32	2	4039	2	MYOM3	1	24432564	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2273569	24432564	224818057	6	768											
UBXN11	91544	broad.mit.edu	37	chr1	26620764	26620764	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagactgtcttgctctctGagtcctcctggtccatgggc	4	13	11	13	0	2	2	0	2	2	1	6	3	5	2	3	2	1	1	3	2	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:26620764G>A	uc001blw.2	-	9	764	c.491C>T	c.(490-492)TCA>TTA	p.S164L	UBXN11_uc001blz.1_Missense_Mutation_p.S131L|UBXN11_uc001blv.2_Missense_Mutation_p.S126L|UBXN11_uc001bly.2_Intron|UBXN11_uc001blx.2_Intron|UBXN11_uc001bma.2_Missense_Mutation_p.S131L|UBXN11_uc001bmb.1_Missense_Mutation_p.S164L|UBXN11_uc010ofb.1_Missense_Mutation_p.S89L|UBXN11_uc010ofc.1_Missense_Mutation_p.S6L	NM_183008	NP_892120	Q5T124	UBX11_HUMAN	socius isoform 2	164						cytoplasm|cytoskeleton				ovary(1)	1						CTTGCTCTCTGAGTCCTCCTG	0.617													55	96					0	0	0	0	A	26620764	A	A	26620764	3	1	4	1	0	0	0	0	1	0	0	0	16981	1294	45	2	1103	2	UBXN11	1	26620764	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2188200	26620764	222629857	7	769											
AIM1L	55057	broad.mit.edu	37	chr1	26648788	26648788	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgggctagggggtccaatCacctgtaggctcatggtggg	6	9	16	10	0	2	0	2	0	0	0	3	0	3	0	3	6	0	3	3	6	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:26648788C>G	uc001bmd.3	-	18	2059	c.1629G>C	c.(1627-1629)GTG>GTC	p.V543V		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	543	Ricin B-type lectin.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		GGGGTCCAATCACCTGTAGGC	0.632													7	98					0	0	0	0	G	26648788	G	G	26648788	2	3	4	1	0	0	0	0	0	0	0	1	431	813	29	2		2	AIM1L	1	26648788	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	28024	26648788	222601833	8	770											
ARID1A	8289	broad.mit.edu	37	chr1	27106087	27106087	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaggaggggcccccacctGatggacctccagaaaaacgg	12	3	12	14	1	0	2	0	1	0	1	1	4	1	4	6	5	1	0	6	5	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:27106087G>C	uc001bmv.1	+	20	6071	c.5698G>C	c.(5698-5700)GAT>CAT	p.D1900H	ARID1A_uc001bmu.1_Missense_Mutation_p.D1683H|ARID1A_uc001bmx.1_Missense_Mutation_p.D746H|ARID1A_uc009vsm.1_Missense_Mutation_p.D228H|ARID1A_uc009vsn.1_Missense_Mutation_p.D142H	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1900					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCCCCCACCTGATGGACCTCC	0.587			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								6	88					0	0	0	0	C	27106087	C	C	27106087	3	2	4	1	0	0	0	0	1	0	0	0	913	1290	45	2	5776	2	ARID1A	1	27106087	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	457299	27106087	222144534	9	771											
SFN	2810	broad.mit.edu	37	chr1	27189782	27189782	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacatggcagccttcatgAaaggcgccgtggagaagggc	11	5	16	9	2	1	2	1	1	0	1	1	4	1	3	2	5	1	1	2	5	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:27189782A>G	uc001bnc.1	+	1	150	c.79A>G	c.(79-81)AAA>GAA	p.K27E		NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	27					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		AGCCTTCATGAAAGGCGCCGT	0.617													31	68					0	0	0	0	G	27189782	G	G	27189782	3	3	4	1	0	0	0	0	1	0	0	0	14224	247	9	5	81	5	SFN	1	27189782	Missense_Mutation	SNP	A	TCGA-BA-4077-01B-01D-1434-08	83695	27189782	222060839	10	772											
SFN	2810	broad.mit.edu	37	chr1	27190331	27190331	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatctgcacaccctcagcGaggactcctacaaagacagc	12	6	8	15	1	2	2	1	1	1	1	3	4	3	3	2	1	4	1	2	1	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:27190331G>T	uc001bnc.1	+	1	699	c.628G>T	c.(628-630)GAG>TAG	p.E210*	uc010ofi.1_RNA	NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	210					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		CACCCTCAGCGAGGACTCCTA	0.617													50	114					3.86236e-30	4.29479e-30	1	0	T	27190331	T	T	27190331	4	4	4	1	0	0	0	0	0	1	0	0	14224	1059	37	3	630	3	SFN	1	27190331	Nonsense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	549	27190331	222060290	11	773											
COL16A1	1307	broad.mit.edu	37	chr1	32160810	32160810	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtcccgggcaccatggaCacagggcggacactgaaagg	10	4	15	12	2	0	1	0	1	0	0	1	3	1	3	2	5	0	2	2	5	1	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:32160810C>A	uc001btk.1	-	11	1323	c.958G>T	c.(958-960)GTC>TTC	p.V320F	COL16A1_uc001btj.1_Missense_Mutation_p.V149F|COL16A1_uc001btl.3_Missense_Mutation_p.V320F	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	320	Nonhelical region 10 (NC10).				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GCACCATGGACACAGGGCGGA	0.627													12	46					3.07112e-06	3.18783e-06	1	0	A	32160810	A	A	32160810	3	1	4	1	0	0	0	0	1	0	0	0	3688	478	17	4	4100	4	COL16A1	1	32160810	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	4970479	32160810	217089811	12	774											
EIF2C1	26523	broad.mit.edu	37	chr1	36384759	36384759	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtgccacacttacgtacGatgcacacgctctgtctcta	8	11	8	14	3	2	0	0	0	2	0	3	1	2	0	1	0	4	4	1	0	3	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:36384759G>T	uc001bzl.2	+	18	2582	c.2369G>T	c.(2368-2370)CGA>CTA	p.R790L	EIF2C1_uc001bzk.2_Missense_Mutation_p.R715L|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	790	Piwi.				negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACTTACGTACGATGCACACGC	0.552													17	35					4.75885e-15	5.10962e-15	1	0	T	36384759	T	T	36384759	3	4	4	1	0	0	0	0	1	0	0	0	5027	1058	37	3	2439	3	EIF2C1	1	36384759	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	4223949	36384759	212865862	13	775											
MFSD2A	84879	broad.mit.edu	37	chr1	40422867	40422867	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgccctgggtttcttccttCagatctacctattggatgtg	5	16	10	10	0	3	1	1	0	2	1	4	2	4	2	3	2	2	1	3	2	2	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:40422867C>T	uc001cev.2	+	2	383	c.202C>T	c.(202-204)CAG>TAG	p.Q68*	MFSD2A_uc010ojb.1_Intron|MFSD2A_uc001ceu.2_Nonsense_Mutation_p.Q68*|MFSD2A_uc010ojc.1_Intron|MFSD2A_uc009vvy.2_RNA	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	68					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						TTTCTTCCTTCAGATCTACCT	0.527													150	284					0	0	0	0	T	40422867	T	T	40422867	4	4	4	1	0	0	0	0	0	1	0	0	9583	827	29	2	208	2	MFSD2A	1	40422867	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	4038108	40422867	208827754	14	776											
CCDC30	728621	broad.mit.edu	37	chr1	43021987	43021987	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgaagcctgaggaaattGtgaggcttagagaagagctg	13	8	14	6	0	0	5	0	3	0	2	0	7	0	6	2	2	2	2	2	2	4	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:43021987G>T	uc009vwk.1	+	5	696	c.586G>T	c.(586-588)GTG>TTG	p.V196L	CCDC30_uc001chm.2_5'UTR|CCDC30_uc001chn.2_Intron|CCDC30_uc010oju.1_RNA|CCDC30_uc001chp.2_Intron	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	196	Potential.										0						TGAGGAAATTGTGAGGCTTAG	0.463													15	37					1.49906e-05	1.54867e-05	1	0	T	43021987	T	T	43021987	3	4	4	1	0	0	0	0	1	0	0	0	2818	1377	48	4	600	4	CCDC30	1	43021987	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2599120	43021987	206228634	15	777											
ERI3	79033	broad.mit.edu	37	chr1	44820585	44820585	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccggggtgttgcccccaactCgggcccatccaagtccaggg	6	6	13	16	2	0	0	0	0	0	0	3	0	2	0	6	4	2	1	6	4	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:44820585C>G	uc001clt.2	-	1	355	c.114G>C	c.(112-114)CCG>CCC	p.P38P	ERI3_uc010okv.1_5'Flank|ERI3_uc009vxg.2_Silent_p.P38P|ERI3_uc010okw.1_5'UTR|ERI3_uc001clu.2_5'UTR	NM_024066	NP_076971	O43414	ERI3_HUMAN	prion protein interacting protein	38						intracellular	exonuclease activity|metal ion binding|nucleic acid binding			ovary(2)|large_intestine(1)	3						GCCCCCAACTCGGGCCCATCC	0.697													4	42					0	0	0	0	G	44820585	G	G	44820585	2	3	4	1	0	0	0	0	0	0	0	1	5253	871	31	3		3	ERI3	1	44820585	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1798598	44820585	204430036	16	778											
PTCH2	8643	broad.mit.edu	37	chr1	45296710	45296710	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtccactggatatccgggCggccgctgagggaaaagcct	8	7	15	11	3	0	1	0	1	0	0	2	3	2	3	4	5	1	1	4	5	3	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:45296710C>T	uc010olf.1	-	6	635	c.623G>A	c.(622-624)CGC>CAC	p.R208H	PTCH2_uc010olg.1_Intron	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	208	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					GATATCCGGGCGGCCGCTGAG	0.612									Basal_Cell_Nevus_syndrome				19	28					0	0	0	0	T	45296710	T	T	45296710	3	4	4	1	0	0	0	0	1	0	0	0	12793	768	27	1	3076	1	PTCH2	1	45296710	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	476125	45296710	203953911	17	779											
TMEM48	55706	broad.mit.edu	37	chr1	54233687	54233687	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgaagtcttttctgatgttCtgcagatgcttgcacagcac	8	15	9	9	0	3	3	0	2	3	1	3	3	3	3	0	0	4	5	0	0	1	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:54233687C>T	uc001cvs.2	-	18	2222	c.1981G>A	c.(1981-1983)GAA>AAA	p.E661K	TMEM48_uc010onu.1_Missense_Mutation_p.E621K|TMEM48_uc001cvt.2_Missense_Mutation_p.E538K|TMEM48_uc009vzk.2_RNA|TMEM48_uc010onv.1_Missense_Mutation_p.E326K	NM_018087	NP_060557	Q9BTX1	NDC1_HUMAN	transmembrane protein 48	661	Cytoplasmic (Potential).				mRNA transport|nuclear pore complex assembly|nuclear pore distribution|protein transport|transmembrane transport	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore			ovary(1)|pancreas(1)	2						TTCTGATGTTCTGCAGATGCT	0.338													9	73					0	0	0	0	T	54233687	T	T	54233687	3	4	4	1	0	0	0	0	1	0	0	0	16238	922	32	2	47	2	TMEM48	1	54233687	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	8936977	54233687	195016934	18	780											
YIPF1	54432	broad.mit.edu	37	chr1	54332512	54332512	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taggagacgatgttcataacTttgctgtttctccacatgag	10	14	9	8	1	2	2	1	1	1	1	3	4	2	2	1	1	2	3	1	1	2	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:54332512T>C	uc001cvu.2	-	8	904	c.567A>G	c.(565-567)AAA>AAG	p.K189K	YIPF1_uc001cvv.2_RNA|YIPF1_uc001cvw.2_RNA|YIPF1_uc001cvx.2_RNA|YIPF1_uc001cvy.2_RNA	NM_018982	NP_061855	Q9Y548	YIPF1_HUMAN	Yip1 domain family, member 1	189	Cytoplasmic (Potential).					integral to membrane|transport vesicle				large_intestine(1)|ovary(1)	2						TGTTCATAACTTTGCTGTTTC	0.458													8	82					0	0	0	0	C	54332512	C	C	54332512	2	2	4	1	0	0	0	0	0	0	0	1	17545	1606	56	5		5	YIPF1	1	54332512	Silent	SNP	T	TCGA-BA-4077-01B-01D-1434-08	98825	54332512	194918109	19	781											
SERBP1	26135	broad.mit.edu	37	chr1	67889986	67889986	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attataagatatttgtttctGaatgtatttgggggactctc	10	18	9	4	0	2	2	0	1	2	1	3	3	2	3	0	2	0	2	0	2	5	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:67889986G>A	uc001ddv.2	-	5	855	c.715C>T	c.(715-717)CAG>TAG	p.Q239*	SERBP1_uc001ddx.2_Nonsense_Mutation_p.Q233*|SERBP1_uc001ddy.2_Intron|SERBP1_uc001ddw.2_Intron	NM_001018067	NP_001018077	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1 isoform 1	239					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			skin(1)	1						ATTTGTTTCTGAATGTATTTG	0.363													10	117					0	0	0	0	A	67889986	A	A	67889986	4	1	4	1	0	0	0	0	0	1	0	0	14140	1299	45	2	527	2	SERBP1	1	67889986	Nonsense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	13557474	67889986	181360635	20	782											
RBMXL1	494115	broad.mit.edu	37	chr1	89448482	89448482	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggaagccctctttcttgtCtgccaaccctgtcacaactt	7	12	8	14	0	4	0	1	0	3	0	4	1	4	1	3	2	4	0	3	2	3	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:89448482C>G	uc009wcx.2	-	3	1744	c.1028G>C	c.(1027-1029)AGA>ACA	p.R343T	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Missense_Mutation_p.R343T	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	343	Ser-rich.						nucleotide binding|RNA binding				0						TCTTTCTTGTCTGCCAACCCT	0.512													75	245					0	0	0	0	G	89448482	G	G	89448482	3	3	4	1	0	0	0	0	1	0	0	0	13218	913	32	2	148	2	RBMXL1	1	89448482	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	21558496	89448482	159802139	21	783											
FNDC7	163479	broad.mit.edu	37	chr1	109275982	109275990	+	In_Frame_Del	DEL	TTACAGCAC	-	-																															gcctccaggggctctgccaaTtacagcactgacctctatgg																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:109275982_109275990delTTACAGCAC	uc001dvx.2	+	10	1968_1976	c.1968_1976delTTACAGCAC	c.(1966-1977)AATTACAGCACT>AAT	p.YST657del	FNDC7_uc010ova.1_In_Frame_Del_p.YST424del	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	658_660	Fibronectin type-III 8.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		GCTCTGCCAATTACAGCACTGACCTCTAT	0.531													---	---	---								-	109275990	-	-	109275982	7	5	4	1	0	1	0	1	0	0	0	0	6005	1490	52	0	2006	0	FNDC7	1	109275982	In_Frame_Del	DEL	TTACAGCAC	TCGA-BA-4077-01B-01D-1434-08	19827500	109275982	139974639	22	784											
WDR77	79084	broad.mit.edu	37	chr1	111989744	111989744	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaactcagtaccacctgctGagcaaggtcccaaaccttga	12	8	8	13	0	1	3	1	3	0	0	2	3	2	3	4	1	5	3	4	1	4	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:111989744G>A	uc001ebb.2	-	4	505	c.466C>T	c.(466-468)CAG>TAG	p.Q156*	WDR77_uc010owd.1_RNA|WDR77_uc010owe.1_Intron|ATP5F1_uc009wgf.1_5'Flank|ATP5F1_uc001ebc.2_5'Flank|ATP5F1_uc001ebd.3_5'Flank	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	156	WD 2.				ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		ACCACCTGCTGAGCAAGGTCC	0.388													31	116					0	0	0	0	A	111989744	A	A	111989744	4	1	4	1	0	0	0	0	0	1	0	0	17395	1299	45	2	590	2	WDR77	1	111989744	Nonsense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2713762	111989744	137260877	23	785											
CAPZA1	829	broad.mit.edu	37	chr1	113212164	113212164	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcttccttccttcattaGaatgaagcccaaactgccaa	11	12	4	14	0	2	2	1	1	1	1	4	2	4	2	5	0	3	0	5	0	5	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:113212164G>T	uc001ecj.1	+	9	1050	c.658_splice	c.e9-1	p.N220_splice		NM_006135	NP_006126	P52907	CAZA1_HUMAN	F-actin capping protein alpha-1 subunit						actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex|WASH complex	actin binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCCTTCATTAGAATGAAGCCC	0.299													15	68					1.52009e-12	1.62416e-12	1	0	T	113212164	T	T	113212164	5	4	4	1	0	0	0	0	0	0	1	0	2652	956	33	2	691	2	CAPZA1	1	113212164	Splice_Site	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1222420	113212164	136038457	24	786											
FLG	2312	broad.mit.edu	37	chr1	152278805	152278805	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtgacgcgaccctgagtGcctggagccgtctcctgatt	6	10	13	12	3	1	3	0	3	1	0	2	5	1	4	4	2	2	0	4	2	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:152278805G>T	uc001ezu.1	-	3	8593	c.8557C>A	c.(8557-8559)CAC>AAC	p.H2853N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2853	Ser-rich.|Filaggrin 17.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCCTGAGTGCCTGGAGCCG	0.572									Ichthyosis				161	787					3.38734e-80	3.82498e-80	1	0	T	152278805	T	T	152278805	3	4	4	1	0	0	0	0	1	0	0	0	5954	1319	46	4	3632	4	FLG	1	152278805	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	39066641	152278805	96971816	25	787											
NUP210L	91181	broad.mit.edu	37	chr1	153984740	153984740	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttaagattgacaccatttCtgccagtggtgatgaagagc	11	12	10	8	0	1	5	0	3	1	2	1	5	1	5	2	1	2	0	2	1	2	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:153984740C>T	uc001fdw.2	-	34	4832	c.4760G>A	c.(4759-4761)AGA>AAA	p.R1587K	NUP210L_uc009woq.2_Missense_Mutation_p.R496K|NUP210L_uc010peh.1_Missense_Mutation_p.R1587K	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1587						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			GACACCATTTCTGCCAGTGGT	0.383													14	172					0	0	0	0	T	153984740	T	T	153984740	3	4	4	1	0	0	0	0	1	0	0	0	10815	913	32	2	934	2	NUP210L	1	153984740	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1705935	153984740	95265881	26	788											
EFNA4	1945	broad.mit.edu	37	chr1	155039242	155039242	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccgtggtggagctgggcctCaacgattacctagacattgt	8	10	13	10	2	1	1	1	0	0	1	1	3	1	2	3	3	3	1	3	3	3	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:155039242C>G	uc001fhd.2	+	2	237	c.150C>G	c.(148-150)CTC>CTG	p.L50L	EFNA3_uc010pew.1_Intron|EFNA4_uc001fhc.2_Silent_p.L50L|EFNA4_uc001fhe.2_Silent_p.L50L	NM_005227	NP_005218	P52798	EFNA4_HUMAN	ephrin A4 isoform a	50					cell-cell signaling	anchored to membrane|extracellular region|integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity				0	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			AGCTGGGCCTCAACGATTACC	0.627													25	48					0	0	0	0	G	155039242	G	G	155039242	2	3	4	1	0	0	0	0	0	0	0	1	4975	813	29	2		2	EFNA4	1	155039242	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1054502	155039242	94211379	27	789											
FDPS	2224	broad.mit.edu	37	chr1	155279994	155279994	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgctattgcccggctcaagGaggtgagggattcatgactt	9	11	13	8	1	2	2	2	2	0	0	2	4	2	4	1	4	2	2	1	4	2	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:155279994G>A	uc001fkc.2	+	3	556	c.337G>A	c.(337-339)GAG>AAG	p.E113K	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Missense_Mutation_p.E47K|FDPS_uc001fke.2_Missense_Mutation_p.E113K|FDPS_uc001fkf.2_Missense_Mutation_p.E47K	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	113					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	CCGGCTCAAGGAGGTGAGGGA	0.517													9	67					0	0	0	0	A	155279994	A	A	155279994	3	1	4	1	0	0	0	0	1	0	0	0	5835	1175	41	2	343	2	FDPS	1	155279994	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	240752	155279994	93970627	28	790											
SYT11	23208	broad.mit.edu	37	chr1	155838359	155838359	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acggcatcgggtgaagaccaGagtgctgcggaagaccctgg	10	5	16	10	3	0	4	0	1	0	3	1	5	0	5	2	4	2	2	2	4	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:155838359G>A	uc001fmg.2	+	2	901	c.638G>A	c.(637-639)AGA>AAA	p.R213K	SYT11_uc010pgq.1_Intron	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	213	Cytoplasmic (Potential).|C2 1.					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			GTGAAGACCAGAGTGCTGCGG	0.572													5	144					0	0	0	0	A	155838359	A	A	155838359	3	1	4	1	0	0	0	0	1	0	0	0	15533	942	33	2	644	2	SYT11	1	155838359	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	558365	155838359	93412262	29	791											
SELL	6402	broad.mit.edu	37	chr1	169672451	169672451	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgattcacaaatggttttCttcttcccaattaactcagt	11	16	5	9	0	4	1	2	1	2	0	5	2	5	1	1	1	1	1	1	1	3	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:169672451C>T	uc001ggk.2	-	6	1095	c.897G>A	c.(895-897)AAG>AAA	p.K299K	C1orf112_uc001ggj.2_Intron|SELL_uc010pls.1_Silent_p.K252K|SELL_uc001ggl.1_Silent_p.K312K	NM_000655	NP_000646	P14151	LYAM1_HUMAN	selectin L precursor	299	Extracellular (Potential).|Sushi 2.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding				0	all_hematologic(923;0.208)					AAATGGTTTTCTTCTTCCCAA	0.423													3	51					0	0	0	0	T	169672451	T	T	169672451	2	4	4	1	0	0	0	0	0	0	0	1	14081	912	32	2		2	SELL	1	169672451	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	13834092	169672451	79578170	30	792											
SLC9A11	284525	broad.mit.edu	37	chr1	173552647	173552647	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacaaaaaatgctcctacctCtaaaaatagaaaagtggatt	19	9	6	7	0	1	1	0	0	1	1	2	3	2	2	2	1	2	1	2	1	10	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:173552647C>G	uc001giz.2	-	6	1061	c.638G>C	c.(637-639)AGA>ACA	p.R213T	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	213					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						GCTCCTACCTCTAAAAATAGA	0.294													8	104					0	0	0	0	G	173552647	G	G	173552647	3	3	4	1	0	0	0	0	1	0	0	0	14775	913	32	2	2828	2	SLC9A11	1	173552647	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	3880196	173552647	75697974	31	793											
SMG7	9887	broad.mit.edu	37	chr1	183511286	183511286	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaattaatactggaagacccCagtgaagccaaagagaacct	17	6	9	9	0	0	3	0	1	0	2	0	6	0	4	4	1	3	0	4	1	7	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:183511286C>T	uc001gqg.2	+	14	1613	c.1491C>T	c.(1489-1491)CCC>CCT	p.P497P	SMG7_uc010pob.1_Silent_p.P526P|SMG7_uc001gqf.2_Silent_p.P497P|SMG7_uc001gqh.2_Silent_p.P497P|SMG7_uc001gqi.2_Silent_p.P455P|SMG7_uc010poc.1_Silent_p.P455P	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	497					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TGGAAGACCCCAGTGAAGCCA	0.418													107	200					0	0	0	0	T	183511286	T	T	183511286	2	4	4	1	0	0	0	0	0	0	0	1	14862	581	21	4		4	SMG7	1	183511286	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	9958639	183511286	65739335	32	794											
DENND1B	163486	broad.mit.edu	37	chr1	197480010	197480011	+	Frame_Shift_Ins	INS	-	T	T																															ggtgtttgccatggagggcaINSctatcgtcttgcccaagatt																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:197480010_197480011insT	uc010ppe.1	-	22	2185_2186	c.1847_1848insA	c.(1846-1848)AGTfs	p.S616fs	DENND1B_uc010ppf.1_RNA	NM_001142795	NP_001136267	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 1	Error:Variant_position_missing_in_Q6P3S1_after_alignment						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						CATGGAGGGCACTATCGTCTTG	0.455													---	---	---								T	197480011	T	T	197480010	7	5	4	1	0	1	1	0	0	0	0	0	4449	156	6	0	423	0	DENND1B	1	197480010	Frame_Shift_Ins	INS	-	TCGA-BA-4077-01B-01D-1434-08	13968724	197480010	51770611	33	795											
FAM58B	339521	broad.mit.edu	37	chr1	200183441	200183441	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttataccatagacacagaGatcccctaaggccctggccc	12	8	7	14	0	0	2	0	0	0	2	1	3	1	2	5	2	1	0	5	2	4	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:200183441G>C	uc009wzi.1	+	1	786	c.750G>C	c.(748-750)GAG>GAC	p.E250D		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	250					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					TAGACACAGAGATCCCCTAAG	0.532													17	133					0	0	0	0	C	200183441	C	C	200183441	3	2	4	1	0	0	0	0	1	0	0	0	5623	933	33	2	752	2	FAM58B	1	200183441	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2703431	200183441	49067180	34	796											
KDM5B	10765	broad.mit.edu	37	chr1	202742383	202742383	+	Frame_Shift_Del	DEL	A	-	-																															ggtccattttctatccttgcAaacaactgcaaatccacctt																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:202742383delA	uc001gyf.2	-	4	555	c.439delT	c.(439-441)TGCfs	p.C147fs	KDM5B_uc009xag.2_Frame_Shift_Del_p.C147fs|KDM5B_uc001gyg.1_5'UTR	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	147	ARID.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						CTATCCTTGCAAACAACTGCA	0.388													---	---	---								-	202742383	-	-	202742383	7	5	4	1	0	1	0	1	0	0	0	0	8173	130	5	0	4291	0	KDM5B	1	202742383	Frame_Shift_Del	DEL	A	TCGA-BA-4077-01B-01D-1434-08	2558942	202742383	46508238	35	797											
USH2A	7399	broad.mit.edu	37	chr1	215848781	215848781	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggacagtaggagccagctGagagtctggaggggcttcat	9	8	17	7	0	2	1	1	1	1	1	2	5	2	4	1	5	2	3	1	5	1	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:215848781G>A	uc001hku.1	-	63	12859	c.12472C>T	c.(12472-12474)CAG>TAG	p.Q4158*		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4158	Extracellular (Potential).|Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGAGCCAGCTGAGAGTCTGGA	0.532										HNSCC(13;0.011)			6	70					0	0	0	0	A	215848781	A	A	215848781	4	1	4	1	0	0	0	0	0	1	0	0	17104	1299	45	2	3176	2	USH2A	1	215848781	Nonsense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	13106398	215848781	33401840	36	798											
MIA3	375056	broad.mit.edu	37	chr1	222801826	222801826	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgatgatgcattagtcccaGatagcaaacaggggaaacca	16	7	10	8	0	0	3	0	2	0	1	1	4	1	4	2	2	4	2	2	2	4	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:222801826G>C	uc001hnl.2	+	4	1273	c.1264G>C	c.(1264-1266)GAT>CAT	p.D422H	MIA3_uc009xea.1_Missense_Mutation_p.D258H	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	422	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		ATTAGTCCCAGATAGCAAACA	0.383													16	144					0	0	0	0	C	222801826	C	C	222801826	3	2	4	1	0	0	0	0	1	0	0	0	9618	942	33	2	1278	2	MIA3	1	222801826	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	6953045	222801826	26448795	37	799											
GALNT2	2590	broad.mit.edu	37	chr1	230338990	230338990	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttcaaccaggtggagagtGataagcttcgaatggacaga	14	8	13	6	1	1	3	1	1	0	2	2	6	1	4	1	3	2	2	1	3	3	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr1:230338990G>A	uc010pwa.1	+	3	400	c.328G>A	c.(328-330)GAT>AAT	p.D110N	GALNT2_uc010pvy.1_Missense_Mutation_p.D72N|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	110	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GGTGGAGAGTGATAAGCTTCG	0.547													32	152					0	0	0	0	A	230338990	A	A	230338990	3	1	4	1	0	0	0	0	1	0	0	0	6248	1290	45	2	338	2	GALNT2	1	230338990	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	7537164	230338990	18911631	38	800											
KCNF1	3754	broad.mit.edu	37	chr2	11053214	11053214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccgcgtggagcacccgaCgctggagaacgtggagacgg	10	3	16	12	6	0	2	0	0	0	2	0	6	0	3	2	4	3	2	2	4	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:11053214C>T	uc002rax.2	+	1	1152	c.662C>T	c.(661-663)ACG>ATG	p.T221M		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	221						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GAGCACCCGACGCTGGAGAAC	0.637													16	36					0	0	0	0	T	11053214	T	T	11053214	3	4	4	1	0	0	0	0	1	0	0	0	8065	536	19	1	664	1	KCNF1	2	11053214	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08		11053214	232146159	39	801											
CENPO	79172	broad.mit.edu	37	chr2	25039552	25039552	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgactgggcccttgcagaGaaacccactgtgtaacttgc	9	9	10	13	0	0	2	0	1	0	1	0	3	0	2	3	1	4	2	3	1	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:25039552G>C	uc002rfo.1	+	6	821	c.632G>C	c.(631-633)AGA>ACA	p.R211T	CENPO_uc002rfp.1_Missense_Mutation_p.R205T|CENPO_uc002rfq.1_Missense_Mutation_p.R211T	NM_024322	NP_077298	Q9BU64	CENPO_HUMAN	centromere protein O	211					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					CCCTTGCAGAGAAACCCACTG	0.493													267	571					0	0	0	0	C	25039552	C	C	25039552	3	2	4	1	0	0	0	0	1	0	0	0	3254	942	33	2	650	2	CENPO	2	25039552	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	13986338	25039552	218159821	40	802											
GPR113	165082	broad.mit.edu	37	chr2	26534512	26534512	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctccctggctgaaggccCggtcacctgccatgatggaa	7	8	11	15	1	2	2	1	2	1	0	3	3	2	3	5	4	1	1	5	4	2	0	rs148160413	byFrequency	TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:26534512C>T	uc002rhe.3	-	11	2084	c.2084G>A	c.(2083-2085)CGG>CAG	p.R695Q	GPR113_uc010yky.1_Missense_Mutation_p.R626Q|GPR113_uc002rhb.1_Missense_Mutation_p.R298Q|GPR113_uc010eyk.1_Missense_Mutation_p.R496Q|GPR113_uc002rhc.1_Missense_Mutation_p.R298Q|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	695	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGAAGGCCCGGTCACCTGC	0.577													13	27					0	0	0	0	T	26534512	T	T	26534512	3	4	4	1	0	0	0	0	1	0	0	0	6668	652	23	1	1256	1	GPR113	2	26534512	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1494960	26534512	216664861	41	803											
C2orf39	92749	broad.mit.edu	37	chr2	26679336	26679336	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttcttttccagatcaactCtgaactgcaagttcctccca	9	14	4	14	0	3	2	1	1	2	1	6	2	6	2	3	0	3	2	3	0	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:26679336C>G	uc002rhg.2	+	17	2248	c.2174C>G	c.(2173-2175)TCT>TGT	p.S725C		NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	725											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGATCAACTCTGAACTGCAA	0.557													10	68					0	0	0	0	G	26679336	G	G	26679336	3	3	4	1	0	0	0	0	1	0	0	0	2174	913	32	2	2240	2	C2orf39	2	26679336	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	144824	26679336	216520037	42	804											
AGBL5	60509	broad.mit.edu	37	chr2	27278716	27278716	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagttcctgtctccctcctGatgctcctgtttctgacctg	3	15	7	16	0	2	2	0	2	2	0	6	2	5	2	6	0	1	3	6	0	0	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:27278716G>A	uc002rie.2	+	7	1292	c.1075G>A	c.(1075-1077)GAT>AAT	p.D359N	AGBL5_uc002ric.2_Missense_Mutation_p.D359N|AGBL5_uc002rid.2_Missense_Mutation_p.D359N|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	359					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTCCCTCCTGATGCTCCTGT	0.527													25	118					0	0	0	0	A	27278716	A	A	27278716	3	1	4	1	0	0	0	0	1	0	0	0	378	1290	45	2	1097	2	AGBL5	2	27278716	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	599380	27278716	215920657	43	805											
FOSL2	2355	broad.mit.edu	37	chr2	28634820	28634820	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagaggagctggaggaggaGaagtcaggcctgcagaagga	14	3	18	6	0	1	3	1	0	0	3	1	8	1	7	1	6	2	2	1	6	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:28634820G>C	uc002rma.2	+	4	1295	c.486G>C	c.(484-486)GAG>GAC	p.E162D	FOSL2_uc010ymi.1_Missense_Mutation_p.E123D	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	162	Leucine-zipper.				cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					TGGAGGAGGAGAAGTCAGGCC	0.557													4	91					0	0	0	0	C	28634820	C	C	28634820	3	2	4	1	0	0	0	0	1	0	0	0	6020	933	33	2	500	2	FOSL2	2	28634820	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1356104	28634820	214564553	44	806											
LRPPRC	10128	broad.mit.edu	37	chr2	44174430	44174430	+	Frame_Shift_Del	DEL	A	-	-																															gcactaatatgagttgctttAggacatctcttataggttga																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:44174430delA	uc002rtr.2	-	20	2103	c.2045delT	c.(2044-2046)CTAfs	p.L682fs	LRPPRC_uc010yob.1_Frame_Shift_Del_p.L582fs	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	682	PPR 9.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GAGTTGCTTTAGGACATCTCT	0.299													---	---	---								-	44174430	-	-	44174430	7	5	4	1	0	1	0	1	0	0	0	0	9015	420	15	0	2215	0	LRPPRC	2	44174430	Frame_Shift_Del	DEL	A	TCGA-BA-4077-01B-01D-1434-08	15539610	44174430	199024943	45	807											
NRXN1	9378	broad.mit.edu	37	chr2	50850564	50850564	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccaaattaatgaccagaGagacagctccatttttcagg	14	10	7	10	0	1	3	1	1	0	2	3	4	3	3	3	1	1	1	3	1	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:50850564G>T	uc010fbq.2	-	6	2598	c.1121C>A	c.(1120-1122)TCT>TAT	p.S374Y	NRXN1_uc002rxb.3_Missense_Mutation_p.S21Y|NRXN1_uc002rxe.3_Missense_Mutation_p.S341Y|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AATGACCAGAGAGACAGCTCC	0.438													30	146					5.8336e-16	6.27903e-16	1	0	T	50850564	T	T	50850564	3	4	4	1	0	0	0	0	1	0	0	0	10719	942	33	2	3857	2	NRXN1	2	50850564	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	6676134	50850564	192348809	46	808											
ELMOD3	84173	broad.mit.edu	37	chr2	85598302	85598302	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaccagcgccttcgggaaGaaagggacttggtcctgacc	9	7	12	13	2	0	2	0	1	0	1	3	4	2	4	5	3	1	0	5	3	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:85598302G>T	uc002spf.3	+	10	1119	c.454G>T	c.(454-456)GAA>TAA	p.E152*	ELMOD3_uc010fgg.2_RNA|ELMOD3_uc002spg.3_Nonsense_Mutation_p.E152*|ELMOD3_uc002sph.3_Nonsense_Mutation_p.E152*|ELMOD3_uc010ysn.1_Nonsense_Mutation_p.E152*|ELMOD3_uc010yso.1_RNA|ELMOD3_uc010ysp.1_RNA	NM_001135021	NP_001128493	Q96FG2	ELMD3_HUMAN	ELMO/CED-12 domain containing 3 isoform b	152					phagocytosis	cytoskeleton				ovary(2)	2						CCTTCGGGAAGAAAGGGACTT	0.587													11	128					0.000978159	0.00100578	1	0	T	85598302	T	T	85598302	4	4	4	1	0	0	0	0	0	1	0	0	5094	943	33	2	476	2	ELMOD3	2	85598302	Nonsense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	34747738	85598302	157601071	47	809											
PCDP1	200373	broad.mit.edu	37	chr2	120369265	120369265	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctattttggatgaggaatttCagcgacttaaaacagaagtt	14	13	9	5	1	1	2	1	1	0	1	1	5	1	4	0	2	2	1	0	2	5	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:120369265C>T	uc002tmb.2	+	14	1492	c.400C>T	c.(400-402)CAG>TAG	p.Q134*	PCDP1_uc010yyq.1_Nonsense_Mutation_p.Q264*	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	420						cilium	calmodulin binding				0	Colorectal(110;0.196)					TGAGGAATTTCAGCGACTTAA	0.333													18	46					0	0	0	0	T	120369265	T	T	120369265	4	4	4	1	0	0	0	0	0	1	0	0	11626	827	29	2	418	2	PCDP1	2	120369265	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	34770963	120369265	122830108	48	810											
MYO7B	4648	broad.mit.edu	37	chr2	128394403	128394403	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctatcccttcaccaagatctCcagctggagcagcggcagca	10	7	9	15	1	2	1	1	0	1	1	4	2	3	2	3	2	4	4	3	2	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:128394403C>G	uc002top.2	+	46	6217	c.6164C>G	c.(6163-6165)TCC>TGC	p.S2055C	MYO7B_uc002tos.1_Missense_Mutation_p.S165C|MYO7B_uc002tot.2_Missense_Mutation_p.S165C	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	2055	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ACCAAGATCTCCAGCTGGAGC	0.662													3	105					0	0	0	0	G	128394403	G	G	128394403	3	3	4	1	0	0	0	0	1	0	0	0	10136	855	30	2	6342	2	MYO7B	2	128394403	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	8025138	128394403	114804970	49	811											
NXPH2	11249	broad.mit.edu	37	chr2	139429126	139429126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taacaaacaggcgcaggggaCtgatgatccttgagtgcacc	12	7	12	10	1	0	3	0	3	0	0	1	4	1	4	2	3	3	2	2	3	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:139429126C>T	uc002tvi.2	-	2	161	c.161G>A	c.(160-162)AGT>AAT	p.S54N		NM_007226	NP_009157	O95156	NXPH2_HUMAN	neurexophilin 2 precursor	54	II.				neuropeptide signaling pathway	extracellular region				ovary(3)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(221;0.101)		GCGCAGGGGACTGATGATCCT	0.572													89	179					0	0	0	0	T	139429126	T	T	139429126	3	4	4	1	0	0	0	0	1	0	0	0	10845	565	20	4	637	4	NXPH2	2	139429126	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	11034723	139429126	103770247	50	812											
ARHGAP15	55843	broad.mit.edu	37	chr2	144381721	144381727	+	Frame_Shift_Del	DEL	CGACAGC	-	-																															gaagagaagctgaatttggaCgacagccagtgggaggacat																								rs138120208		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:144381721_144381727delCGACAGC	uc002tvm.3	+	12	1174_1180	c.1023_1029delCGACAGC	c.(1021-1029)GACGACAGCfs	p.D341fs	ARHGAP15_uc002tvn.2_Frame_Shift_Del_p.D107fs	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	341_343	Rho-GAP.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TGAATTTGGACGACAGCCAGTGGGAGG	0.449													---	---	---								-	144381727	-	-	144381721	7	5	4	1	0	1	0	1	0	0	0	0	866	535	19	0	1065	0	ARHGAP15	2	144381721	Frame_Shift_Del	DEL	CGACAGC	TCGA-BA-4077-01B-01D-1434-08	4952595	144381721	98817652	51	813											
UPP2	151531	broad.mit.edu	37	chr2	158971685	158971685	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcacaaggagctcgggtttGaggaagctgaagaagacata	14	7	14	6	1	0	4	0	2	0	2	1	6	0	6	0	3	3	4	0	3	5	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:158971685G>C	uc002tzp.2	+	3	447	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	UPP2_uc002tzo.2_Missense_Mutation_p.E142Q	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	85					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						GCTCGGGTTTGAGGAAGCTGA	0.463													15	179					0	0	0	0	C	158971685	C	C	158971685	3	2	4	1	0	0	0	0	1	0	0	0	17081	1291	45	2	442	2	UPP2	2	158971685	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	14589964	158971685	84227688	52	814											
MARCH7	64844	broad.mit.edu	37	chr2	160604337	160604337	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttcaagacagagttccttCatattcacaaggagcaagac	14	10	8	9	0	3	3	3	0	0	3	4	4	4	4	1	1	1	3	1	1	4	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:160604337C>T	uc002uax.2	+	5	658	c.536C>T	c.(535-537)TCA>TTA	p.S179L	MARCH7_uc010foq.2_Missense_Mutation_p.S179L|MARCH7_uc010zcn.1_Missense_Mutation_p.S123L|MARCH7_uc010for.2_Missense_Mutation_p.S141L|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	179	Ser-rich.						ligase activity|zinc ion binding				0						AGAGTTCCTTCATATTCACAA	0.328													58	67					0	0	0	0	T	160604337	T	T	160604337	3	4	4	1	0	0	0	0	1	0	0	0	9359	838	29	2	550	2	MARCH7	2	160604337	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1632652	160604337	82595036	53	815											
TTN	7273	broad.mit.edu	37	chr2	179403524	179403524	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtagagtgacactatctttgGatattgaaagaatctcaagt	14	13	9	5	0	2	4	1	2	2	2	3	5	2	5	0	1	0	1	0	1	6	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:179403524G>A	uc010zfg.1	-	303	91552	c.91328C>T	c.(91327-91329)TCC>TTC	p.S30443F	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S24138F|TTN_uc010zfi.1_Missense_Mutation_p.S24071F|TTN_uc010zfj.1_Missense_Mutation_p.S23946F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31370							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTATCTTTGGATATTGAAAG	0.383													37	249					0	0	0	0	A	179403524	A	A	179403524	3	1	4	1	0	0	0	0	1	0	0	0	16803	1174	41	2	8983	2	TTN	2	179403524	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	18799187	179403524	63795849	54	816											
CCDC141	285025	broad.mit.edu	37	chr2	179733905	179733905	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatcctcgtaatcctggattCtctctttctgtttttgatgg	5	20	7	9	1	3	1	0	1	3	0	7	2	5	2	2	2	0	2	2	2	2	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:179733905C>G	uc002unf.1	-	5	665	c.608G>C	c.(607-609)AGA>ACA	p.R203T		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	203	Potential.						protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			ATCCTGGATTCTCTCTTTCTG	0.418													6	254					0	0	0	0	G	179733905	G	G	179733905	3	3	4	1	0	0	0	0	1	0	0	0	2787	913	32	2	2055	2	CCDC141	2	179733905	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	330381	179733905	63465468	55	817											
HSPD1	3329	broad.mit.edu	37	chr2	198353732	198353732	+	Frame_Shift_Del	DEL	C	-	-																															ataatgaatgttaccttcagCacagccactccatctgaaag																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:198353732delC	uc002uui.2	-	9	1346	c.1209delG	c.(1207-1209)GTGfs	p.V403fs	HSPD1_uc002uuj.2_Frame_Shift_Del_p.V401fs|HSPD1_uc010zgx.1_Frame_Shift_Del_p.V394fs|HSPD1_uc010fsm.2_Frame_Shift_Del_p.V214fs|HSPD1_uc002uuk.2_Frame_Shift_Del_p.V403fs	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	403					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			TTACCTTCAGCACAGCCACTC	0.363													---	---	---								-	198353732	-	-	198353732	7	5	4	1	0	1	0	1	0	0	0	0	7467	697	25	0	528	0	HSPD1	2	198353732	Frame_Shift_Del	DEL	C	TCGA-BA-4077-01B-01D-1434-08	18619827	198353732	44845641	56	818											
CPS1	1373	broad.mit.edu	37	chr2	211521293	211521293	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catgttgaagatgcaggtgtCcactcgggagatgccactct	9	10	12	10	1	1	3	0	1	1	2	3	4	2	3	2	2	2	2	2	2	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:211521293C>A	uc002vee.3	+	30	3735	c.3603C>A	c.(3601-3603)GTC>GTA	p.V1201V	CPS1_uc010fur.2_Silent_p.V1207V|CPS1_uc010fus.2_Silent_p.V750V	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1201	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		ATGCAGGTGTCCACTCGGGAG	0.413													103	57					1.1777e-47	1.32302e-47	1	0	A	211521293	A	A	211521293	2	1	4	1	0	0	0	0	0	0	0	1	3838	842	30	2		2	CPS1	2	211521293	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	13167561	211521293	31678080	57	819											
SMARCAL1	50485	broad.mit.edu	37	chr2	217279529	217279529	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttattggcagaacagcatcaGaggactagctcgggcacctc	11	8	11	11	1	1	2	1	0	0	2	3	3	1	3	1	3	3	4	1	3	3	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:217279529G>C	uc002vgc.3	+	3	432	c.102G>C	c.(100-102)CAG>CAC	p.Q34H	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.Q34H|SMARCAL1_uc010fvg.2_Missense_Mutation_p.Q34H	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	34	Potential.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		AACAGCATCAGAGGACTAGCT	0.522									Schimke_Immuno-Osseous_Dysplasia				53	105					0	0	0	0	C	217279529	C	C	217279529	3	2	4	1	0	0	0	0	1	0	0	0	14837	933	33	2	104	2	SMARCAL1	2	217279529	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	5758236	217279529	25919844	58	820											
ZNF142	7701	broad.mit.edu	37	chr2	219510915	219510915	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaggtcccctgcatgttttCgcatgtgcacacggaggtag	7	11	13	10	2	0	1	0	1	0	0	2	2	1	2	2	3	2	5	2	3	1	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:219510915C>T	uc002vin.2	-	7	1866	c.1430G>A	c.(1429-1431)CGA>CAA	p.R477Q	ZNF142_uc002vil.2_Missense_Mutation_p.R438Q|ZNF142_uc010fvt.2_Missense_Mutation_p.R314Q|ZNF142_uc002vim.2_Missense_Mutation_p.R314Q	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	477	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TGCATGTTTTCGCATGTGCAC	0.512													21	93					0	0	0	0	T	219510915	T	T	219510915	3	4	4	1	0	0	0	0	1	0	0	0	17798	884	31	1	3649	1	ZNF142	2	219510915	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2231386	219510915	23688458	59	821											
ZNF142	7701	broad.mit.edu	37	chr2	219510998	219510998	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccttggtgttggagtgggtCagcatgtgcttggataggta	6	14	16	5	0	1	0	1	0	0	0	2	2	2	2	1	5	2	4	1	5	2	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:219510998C>T	uc002vin.2	-	7	1783	c.1347G>A	c.(1345-1347)CTG>CTA	p.L449L	ZNF142_uc002vil.2_Silent_p.L410L|ZNF142_uc010fvt.2_Silent_p.L286L|ZNF142_uc002vim.2_Silent_p.L286L	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	449	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TGGAGTGGGTCAGCATGTGCT	0.527													22	70					0	0	0	0	T	219510998	T	T	219510998	2	4	4	1	0	0	0	0	0	0	0	1	17798	813	29	2		2	ZNF142	2	219510998	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	83	219510998	23688375	60	822											
COL6A3	1293	broad.mit.edu	37	chr2	238255176	238255176	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggtagccagggtctcccttCtgtccaactatccctggagg	6	10	12	13	0	2	0	0	0	2	0	5	1	4	1	4	4	2	1	4	4	3	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:238255176C>T	uc002vwl.2	-	32	7347	c.7062G>A	c.(7060-7062)CAG>CAA	p.Q2354Q	COL6A3_uc002vwo.2_Silent_p.Q2148Q|COL6A3_uc010znj.1_Silent_p.Q1747Q|COL6A3_uc002vwp.1_Silent_p.Q175Q	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2354	Collagen-like 5.|Triple-helical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGTCTCCCTTCTGTCCAACTA	0.468													39	34					0	0	0	0	T	238255176	T	T	238255176	2	4	4	1	0	0	0	0	0	0	0	1	3716	912	32	2		2	COL6A3	2	238255176	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	18744178	238255176	4944197	61	823											
OR6B3	150681	broad.mit.edu	37	chr2	240985469	240985470	+	Missense_Mutation	DNP	GG	CT	CT																															aggatgaaggtgccgaccctGgtgacattctccccactcat																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr2:240985469_240985470GG>CT	uc010zoe.1	-	1	20_21	c.20_21CC>AG	c.(19-21)ACC>AAG	p.T7K		NM_173351	NP_775486	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		TGCCGACCCTGGTGACATTCTC	0.599													29	19					0	0	0	0	CT	240985470	CT	CT	240985469	3	2	4	1	0	0	0	0	1	0	0	0	11243	1335	47	4	977	4	OR6B3	2	240985469	Missense_Mutation	DNP	GG	TCGA-BA-4077-01B-01D-1434-08	2730293	240985469	2213904	62	824											
HDAC11	79885	broad.mit.edu	37	chr3	13538259	13538259	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctttgctgttgctaccatCacagaaatcccccccgttat	8	13	5	15	1	1	1	1	0	0	1	3	1	3	1	5	0	3	4	5	0	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:13538259C>T	uc003bxy.2	+	4	409	c.276C>T	c.(274-276)ATC>ATT	p.I92I	HDAC11_uc010heb.2_Silent_p.I64I|HDAC11_uc011aux.1_Intron|HDAC11_uc003bxz.2_Silent_p.I64I|HDAC11_uc011auy.1_Intron	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	92	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						TTGCTACCATCACAGAAATCC	0.572											OREG0015411	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	87					0	0	0	0	T	13538259	T	T	13538259	2	4	4	1	0	0	0	0	0	0	0	1	7045	816	29	2		2	HDAC11	3	13538259	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08		13538259	184484171	63	825											
TOP2B	7155	broad.mit.edu	37	chr3	25670595	25670595	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatggccaattgtgatggatGaaattaataagcaggccttt	13	12	11	5	0	0	2	0	2	0	0	0	4	0	3	2	3	1	1	2	3	4	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:25670595G>A	uc011awn.1	-	14	1774	c.1731C>T	c.(1729-1731)TTC>TTT	p.F577F	TOP2B_uc003cdj.2_Silent_p.F572F	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	577					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						TGTGATGGATGAAATTAATAA	0.274													43	49					0	0	0	0	A	25670595	A	A	25670595	2	1	4	1	0	0	0	0	0	0	0	1	16433	1281	45	2		2	TOP2B	3	25670595	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	12132336	25670595	172351835	64	826											
KIF15	56992	broad.mit.edu	37	chr3	44844322	44844322	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagatagagcaccaccccaGagttgcaaagtatgctatgg	14	7	10	10	0	0	3	0	0	0	3	0	3	0	3	3	1	3	5	3	1	4	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:44844322G>C	uc003cnx.3	+	14	1675	c.1526G>C	c.(1525-1527)AGA>ACA	p.R509T	KIF15_uc010hiq.2_Missense_Mutation_p.R412T|KIF15_uc003cny.1_Missense_Mutation_p.R144T	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	509	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		CACCACCCCAGAGTTGCAAAG	0.383													18	100					0	0	0	0	C	44844322	C	C	44844322	3	2	4	1	0	0	0	0	1	0	0	0	8316	942	33	2	1580	2	KIF15	3	44844322	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	19173727	44844322	153178108	65	827											
CLEC3B	7123	broad.mit.edu	37	chr3	45077096	45077096	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccttccacgaggccagcgagGactgcatctcgcgcgggggc	6	5	15	15	5	1	0	0	0	1	0	3	3	2	1	3	4	2	1	3	4	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:45077096G>C	uc003cok.3	+	3	385	c.289G>C	c.(289-291)GAC>CAC	p.D97H	CLEC3B_uc003col.2_Missense_Mutation_p.D55H	NM_003278	NP_003269	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	97	C-type lectin.				skeletal system development	extracellular space	protein binding|sugar binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCCAGCGAGGACTGCATCTC	0.632													15	29					0	0	0	0	C	45077096	C	C	45077096	3	2	4	1	0	0	0	0	1	0	0	0	3526	1174	41	2	299	2	CLEC3B	3	45077096	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	232774	45077096	152945334	66	828											
PTPN23	25930	broad.mit.edu	37	chr3	47451515	47451515	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaagcaggagacccccctGaggagctgcgcagcctcccc	8	4	13	16	1	0	2	0	1	0	1	1	5	1	4	6	3	4	3	6	3	1	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:47451515G>A	uc003crf.1	+	20	2323	c.2227G>A	c.(2227-2229)GAG>AAG	p.E743K	PTPN23_uc011baw.1_Missense_Mutation_p.E708K|PTPN23_uc011bax.1_Intron|PTPN23_uc011bay.1_Missense_Mutation_p.E613K	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	743	Pro-rich.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGACCCCCCTGAGGAGCTGCG	0.682													9	6					0	0	0	0	A	47451515	A	A	47451515	3	1	4	1	0	0	0	0	1	0	0	0	12853	1291	45	2	2305	2	PTPN23	3	47451515	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2374419	47451515	150570915	67	829											
P4HTM	54681	broad.mit.edu	37	chr3	49040007	49040007	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggagatgtacgccgcgatCaaggctgaccctgatggtga	10	7	14	10	3	1	4	1	3	0	1	1	6	1	4	2	3	1	2	2	3	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:49040007C>G	uc003cvg.2	+	4	1051	c.702C>G	c.(700-702)ATC>ATG	p.I234M	P4HTM_uc003cvh.2_Missense_Mutation_p.I234M|P4HTM_uc010hkm.1_Missense_Mutation_p.I120M	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	234	Lumenal (Potential).|EF-hand 2.					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	ACGCCGCGATCAAGGCTGACC	0.562													53	52					0	0	0	0	G	49040007	G	G	49040007	3	3	4	1	0	0	0	0	1	0	0	0	11414	816	29	2	716	2	P4HTM	3	49040007	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1588492	49040007	148982423	68	830											
APPL1	26060	broad.mit.edu	37	chr3	57291322	57291322	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagttcaggatccttaggAtctgagtctacaaatttggc	11	12	10	8	0	3	1	1	1	2	0	4	3	4	3	1	3	2	2	1	3	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:57291322A>G	uc003dio.2	+	15	1443	c.1296A>G	c.(1294-1296)GGA>GGG	p.G432G	APPL1_uc010hnb.2_Silent_p.G432G|APPL1_uc011bey.1_Silent_p.G415G	NM_012096	NP_036228	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH	432					apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)		GATCCTTAGGATCTGAGTCTA	0.433													70	41					0	0	0	0	G	57291322	G	G	57291322	2	3	4	1	0	0	0	0	0	0	0	1	817	320	12	5		5	APPL1	3	57291322	Silent	SNP	A	TCGA-BA-4077-01B-01D-1434-08	8251315	57291322	140731108	69	831											
BBX	56987	broad.mit.edu	37	chr3	107491933	107491933	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctaaaaaagaaaaagaaGaaaagcaaaatggatcgaca	26	3	8	4	1	0	3	0	0	0	3	1	5	0	4	0	1	2	2	0	1	11	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:107491933G>C	uc010hpr.2	+	11	1692	c.1365G>C	c.(1363-1365)AAG>AAC	p.K455N	BBX_uc003dwk.3_Missense_Mutation_p.K455N|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Missense_Mutation_p.K476N|BBX_uc003dwm.3_Missense_Mutation_p.K455N|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	455	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			AGAAAAAGAAGAAAAGCAAAA	0.388													160	77					0	0	0	0	C	107491933	C	C	107491933	3	2	4	1	0	0	0	0	1	0	0	0	1345	933	33	2	1395	2	BBX	3	107491933	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	50200611	107491933	90530497	70	832			1	1		8	7	269	N	G	1.46067e-18
BBX	56987	broad.mit.edu	37	chr3	107492069	107492069	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaaggagactggggcataGagaaacttggagatacccct	15	6	12	8	0	0	3	0	0	0	3	0	6	0	3	2	4	2	1	2	4	5	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:107492069G>C	uc010hpr.2	+	11	1828	c.1501G>C	c.(1501-1503)GAG>CAG	p.E501Q	BBX_uc003dwk.3_Missense_Mutation_p.E501Q|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Missense_Mutation_p.E522Q|BBX_uc003dwm.3_Missense_Mutation_p.E501Q|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	501	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			CTGGGGCATAGAGAAACTTGG	0.473													115	72					0	0	0	0	C	107492069	C	C	107492069	3	2	4	1	0	0	0	0	1	0	0	0	1345	943	33	2	1531	2	BBX	3	107492069	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	136	107492069	90530361	71	833			1	1		8	7	269	N	G	1.46067e-18
BBX	56987	broad.mit.edu	37	chr3	107492081	107492081	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggcatagagaaacttggaGatacccctcgcaagaaggtc	13	6	13	9	1	0	3	0	0	0	3	2	5	0	3	2	4	2	2	2	4	5	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:107492081G>C	uc010hpr.2	+	11	1840	c.1513G>C	c.(1513-1515)GAT>CAT	p.D505H	BBX_uc003dwk.3_Missense_Mutation_p.D505H|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Missense_Mutation_p.D526H|BBX_uc003dwm.3_Missense_Mutation_p.D505H|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	505	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GAAACTTGGAGATACCCCTCG	0.458													110	69					0	0	0	0	C	107492081	C	C	107492081	3	2	4	1	0	0	0	0	1	0	0	0	1345	942	33	2	1543	2	BBX	3	107492081	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	12	107492081	90530349	72	834			1	1		8	7	269	N	G	1.46067e-18
BBX	56987	broad.mit.edu	37	chr3	107492134	107492134	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtggcaagggaagcattttGgatgccaagccaccaaagaa	15	6	12	8	0	0	1	0	0	0	1	0	3	0	3	3	3	3	2	3	3	5	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:107492134G>C	uc010hpr.2	+	11	1893	c.1566G>C	c.(1564-1566)TTG>TTC	p.L522F	BBX_uc003dwk.3_Missense_Mutation_p.L522F|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Missense_Mutation_p.L543F|BBX_uc003dwm.3_Missense_Mutation_p.L522F|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	522	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GAAGCATTTTGGATGCCAAGC	0.468													34	56					0	0	0	0	C	107492134	C	C	107492134	3	2	4	1	0	0	0	0	1	0	0	0	1345	1339	47	4	1596	4	BBX	3	107492134	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	53	107492134	90530296	73	835			1	1		8	7	269	N	G	1.46067e-18
BBX	56987	broad.mit.edu	37	chr3	107492152	107492152	+	Frame_Shift_Del	DEL	G	-	-																															ttggatgccaagccaccaaaGaaaaaagtgaaatcaagaga																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:107492152delG	uc010hpr.2	+	11	1911	c.1584delG	c.(1582-1584)AAGfs	p.K528fs	BBX_uc003dwk.3_Frame_Shift_Del_p.K528fs|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Frame_Shift_Del_p.K549fs|BBX_uc003dwm.3_Frame_Shift_Del_p.K528fs|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	528	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			AGCCACCAAAGAAAAAAGTGA	0.448													---	---	---								-	107492152	-	-	107492152	7	5	4	1	0	1	0	1	0	0	0	0	1345	933	33	0	1614	0	BBX	3	107492152	Frame_Shift_Del	DEL	G	TCGA-BA-4077-01B-01D-1434-08	18	107492152	90530278	74	836			1	1		8	7	269	N	G	1.46067e-18
BBX	56987	broad.mit.edu	37	chr3	107492169	107492169	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagaaaaaagtgaaatcaaGagagaagaaaatgtcaaagg	25	4	10	2	0	2	5	2	1	0	4	2	6	2	5	0	1	0	0	0	1	10	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:107492169G>C	uc010hpr.2	+	11	1928	c.1601G>C	c.(1600-1602)AGA>ACA	p.R534T	BBX_uc003dwk.3_Missense_Mutation_p.R534T|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Missense_Mutation_p.R555T|BBX_uc003dwm.3_Missense_Mutation_p.R534T|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	534	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GTGAAATCAAGAGAGAAGAAA	0.438													7	51					0	0	0	0	C	107492169	C	C	107492169	3	2	4	1	0	0	0	0	1	0	0	0	1345	942	33	2	1631	2	BBX	3	107492169	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	17	107492169	90530261	75	837			1	1		8	7	269	N	G	1.46067e-18
BBX	56987	broad.mit.edu	37	chr3	107492191	107492191	+	Silent	SNP	G	A	A																															gagaagaaaatgtcaaaggaGaaatcctcagacaccaccaa																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:107492191G>A	uc010hpr.2	+	11	1950	c.1623G>A	c.(1621-1623)GAG>GAA	p.E541E	BBX_uc003dwk.3_Silent_p.E541E|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Silent_p.E562E|BBX_uc003dwm.3_Silent_p.E541E|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	541	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			TGTCAAAGGAGAAATCCTCAG	0.433													18	51					0	0	0	0	A	107492191	A	A	107492191	2	1	4	1	0	0	0	0	0	0	0	1	1345	933	33	2		2	BBX	3	107492191	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	22	107492191	90530239	76	838	2	2	1	1		8	7	269	N	G	1.46067e-18
BBX	56987	broad.mit.edu	37	chr3	107492201	107492201	+	Missense_Mutation	SNP	G	A	A																															tgtcaaaggagaaatcctcaGacaccaccaaagagtcaaga																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:107492201G>A	uc010hpr.2	+	11	1960	c.1633G>A	c.(1633-1635)GAC>AAC	p.D545N	BBX_uc003dwk.3_Missense_Mutation_p.D545N|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Missense_Mutation_p.D566N|BBX_uc003dwm.3_Missense_Mutation_p.D545N|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	545					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GAAATCCTCAGACACCACCAA	0.428													20	54					0	0	0	0	A	107492201	A	A	107492201	3	1	4	1	0	0	0	0	1	0	0	0	1345	942	33	2	1663	2	BBX	3	107492201	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	10	107492201	90530229	77	839	2	2	1	1		8	7	269	N	G	1.46067e-18
BOC	91653	broad.mit.edu	37	chr3	112968688	112968688	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acggcgtggagaggaatgagGcctgaggtcacactggcttg	9	7	17	8	2	1	3	1	2	0	1	1	5	1	4	1	6	0	1	1	6	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:112968688G>T	uc003dzx.2	+	3	660	c.39G>T	c.(37-39)AGG>AGT	p.R13S	BOC_uc010hqi.2_Missense_Mutation_p.R13S|BOC_uc003dzy.2_Missense_Mutation_p.R13S|BOC_uc003dzz.2_Missense_Mutation_p.R13S|BOC_uc003dzw.1_Missense_Mutation_p.R13S|BOC_uc003eaa.1_Missense_Mutation_p.R13S	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	13					cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GAGGAATGAGGCCTGAGGTCA	0.552													16	126					3.62473e-10	3.83537e-10	1	0	T	112968688	T	T	112968688	3	4	4	1	0	0	0	0	1	0	0	0	1484	1194	42	4	41	4	BOC	3	112968688	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	5476487	112968688	85053742	78	840											
CCDC52	152185	broad.mit.edu	37	chr3	113187686	113187686	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgagtctagagtctcagtaGattcttcaggctgaagcctg	9	13	11	8	0	4	4	2	2	3	2	5	4	4	4	1	1	1	2	1	1	3	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:113187686G>C	uc003eag.3	-	9	1103	c.812C>G	c.(811-813)TCT>TGT	p.S271C	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Missense_Mutation_p.S167C	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	271					cell division|mitosis	centriole|spindle	protein binding				0						AGTCTCAGTAGATTCTTCAGG	0.418													25	162					0	0	0	0	C	113187686	C	C	113187686	3	2	4	1	0	0	0	0	1	0	0	0	2835	942	33	2	1795	2	CCDC52	3	113187686	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	218998	113187686	84834744	79	841											
KIAA1407	57577	broad.mit.edu	37	chr3	113724682	113724682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtgctgcttattgccaggtGcactcagagagacattctga	9	12	11	9	0	2	3	1	1	1	2	2	4	2	3	1	1	4	3	1	1	1	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:113724682G>A	uc003eax.2	-	10	1688	c.1541C>T	c.(1540-1542)GCA>GTA	p.A514V	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.A492V|KIAA1407_uc011bip.1_Missense_Mutation_p.A501V	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	514										ovary(2)	2						ATTGCCAGGTGCACTCAGAGA	0.542													39	566					0	0	0	0	A	113724682	A	A	113724682	3	1	4	1	0	0	0	0	1	0	0	0	8268	1319	46	4	1301	4	KIAA1407	3	113724682	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	536996	113724682	84297748	80	842											
ZBTB20	26137	broad.mit.edu	37	chr3	114069347	114069347	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaggggctgtggcaggctGaagaggaaaggcttggggcc	8	5	20	8	0	0	2	0	1	0	1	0	3	0	3	2	8	0	4	2	8	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:114069347G>A	uc003ebi.2	-	4	1758	c.1578C>T	c.(1576-1578)TTC>TTT	p.F526F	ZBTB20_uc003ebj.2_Silent_p.F453F|ZBTB20_uc010hqp.2_Silent_p.F453F|ZBTB20_uc003ebk.2_Silent_p.F453F|ZBTB20_uc003ebl.2_Silent_p.F453F|ZBTB20_uc003ebm.2_Silent_p.F453F|ZBTB20_uc003ebn.2_Silent_p.F453F|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	526					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GTGGCAGGCTGAAGAGGAAAG	0.642													32	170					0	0	0	0	A	114069347	A	A	114069347	2	1	4	1	0	0	0	0	0	0	0	1	17596	1281	45	2		2	ZBTB20	3	114069347	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	344665	114069347	83953083	81	843											
ZBTB20	26137	broad.mit.edu	37	chr3	114070078	114070078	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtgatccagctggggtcttCcatgtggtggtcgcggggca	4	11	17	9	2	1	1	0	1	1	0	4	1	3	1	2	6	1	2	2	6	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:114070078C>T	uc003ebi.2	-	4	1027	c.847G>A	c.(847-849)GAA>AAA	p.E283K	ZBTB20_uc003ebj.2_Missense_Mutation_p.E210K|ZBTB20_uc010hqp.2_Missense_Mutation_p.E210K|ZBTB20_uc003ebk.2_Missense_Mutation_p.E210K|ZBTB20_uc003ebl.2_Missense_Mutation_p.E210K|ZBTB20_uc003ebm.2_Missense_Mutation_p.E210K|ZBTB20_uc003ebn.2_Missense_Mutation_p.E210K|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CTGGGGTCTTCCATGTGGTGG	0.662													6	208					0	0	0	0	T	114070078	T	T	114070078	3	4	4	1	0	0	0	0	1	0	0	0	17596	864	30	2	1386	2	ZBTB20	3	114070078	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	731	114070078	83952352	82	844											
LSAMP	4045	broad.mit.edu	37	chr3	115561400	115561400	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgtggtggcttcattgctCttggattctgtgatagtggg	4	16	14	7	0	3	1	1	1	2	0	3	2	3	2	1	4	1	2	1	4	1	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:115561400C>G	uc003ebt.2	-	5	1175	c.675G>C	c.(673-675)AAG>AAC	p.K225N	LSAMP_uc011bis.1_Missense_Mutation_p.K225N	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	225	Ig-like C2-type 3.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CTTCATTGCTCTTGGATTCTG	0.453													19	122					0	0	0	0	G	115561400	G	G	115561400	3	3	4	1	0	0	0	0	1	0	0	0	9098	912	32	2	353	2	LSAMP	3	115561400	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1491322	115561400	82461030	83	845											
GOLGB1	2804	broad.mit.edu	37	chr3	121395796	121395796	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaatttcctttaagctgtCattgagctgggtcctgagaa	9	14	11	7	0	1	3	1	3	0	1	3	4	3	3	2	1	2	2	2	1	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:121395796C>G	uc003eei.3	-	17	9232	c.9106G>C	c.(9106-9108)GAC>CAC	p.D3036H	GOLGB1_uc010hrc.2_Missense_Mutation_p.D3041H|GOLGB1_uc003eej.3_Missense_Mutation_p.D3002H	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	3036	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTTAAGCTGTCATTGAGCTGG	0.423													14	217					0	0	0	0	G	121395796	G	G	121395796	3	3	4	1	0	0	0	0	1	0	0	0	6602	826	29	2	697	2	GOLGB1	3	121395796	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	5834396	121395796	76626634	84	846											
KALRN	8997	broad.mit.edu	37	chr3	124376308	124376308	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgcagggcttcatgaagaGaatagaagaaaagggtgtcc	14	7	14	6	0	1	4	1	1	0	3	2	5	2	4	1	2	1	3	1	2	6	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:124376308G>C	uc003ehg.2	+	40	6000	c.5873G>C	c.(5872-5874)AGA>ACA	p.R1958T	KALRN_uc003ehi.2_Missense_Mutation_p.R299T|KALRN_uc003ehk.2_Missense_Mutation_p.R261T|KALRN_uc011bjz.1_Missense_Mutation_p.R50T	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1957	DH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TTCATGAAGAGAATAGAAGAA	0.453													4	129					0	0	0	0	C	124376308	C	C	124376308	3	2	4	1	0	0	0	0	1	0	0	0	8014	942	33	2	6187	2	KALRN	3	124376308	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2980512	124376308	73646122	85	847											
COL6A6	131873	broad.mit.edu	37	chr3	130361868	130361868	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtatgtgcgagaccgcagtcGtaagtaccctgcttaaaatg	11	10	11	9	3	0	1	0	0	0	1	1	2	0	1	2	0	3	5	2	0	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:130361868G>A	uc010htl.2	+	30	5258	c.5227_splice	c.e30+1	p.P1743_splice	COL6A6_uc003eni.3_Splice_Site_p.V6_splice	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor						axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GACCGCAGTCGTAAGTACCCT	0.393													13	80					0	0	0	0	A	130361868	A	A	130361868	5	1	4	1	0	0	0	0	0	0	1	0	3718	1159	40	1	5346	1	COL6A6	3	130361868	Splice_Site	SNP	G	TCGA-BA-4077-01B-01D-1434-08	5985560	130361868	67660562	86	848											
SOX14	8403	broad.mit.edu	37	chr3	137484129	137484129	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cggcgctctgccctacgcgtCcaccctgggctaccagaacg	6	6	11	18	5	1	1	0	0	1	1	2	1	2	1	4	2	4	2	4	2	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:137484129C>T	uc003erm.1	+	1	551	c.503C>T	c.(502-504)TCC>TTC	p.S168F		NM_004189	NP_004180	O95416	SOX14_HUMAN	SRY-box 14	168					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding				0						CCCTACGCGTCCACCCTGGGC	0.687													9	11					0	0	0	0	T	137484129	T	T	137484129	3	4	4	1	0	0	0	0	1	0	0	0	15009	855	30	2	505	2	SOX14	3	137484129	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	7122261	137484129	60538301	87	849											
BCHE	590	broad.mit.edu	37	chr3	165547864	165547864	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaaatcaccatccacggtcgGaccaaagtttactgacaaag	16	7	7	11	2	1	1	1	1	0	0	3	2	2	2	3	2	1	1	3	2	5	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:165547864G>C	uc003fem.3	-	2	1118	c.958C>G	c.(958-960)CCG>GCG	p.P320A	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	320					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	TCCACGGTCGGACCAAAGTTT	0.373													22	171					0	0	0	0	C	165547864	C	C	165547864	3	2	4	1	0	0	0	0	1	0	0	0	1360	1174	41	2	862	2	BCHE	3	165547864	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	28063735	165547864	32474566	88	850											
PLD1	5337	broad.mit.edu	37	chr3	171431715	171431715	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcaattcggattccatatttCgtttctgtctccttcttccc	5	19	4	13	2	4	0	1	0	3	0	9	1	6	1	3	1	0	1	3	1	2	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:171431715C>G	uc003fhs.2	-	9	995	c.879G>C	c.(877-879)ACG>ACC	p.T293T	PLD1_uc003fht.2_Silent_p.T293T	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	293	PH.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TTCCATATTTCGTTTCTGTCT	0.338													215	145					0	0	0	0	G	171431715	G	G	171431715	2	3	4	1	0	0	0	0	0	0	0	1	12100	871	31	3		3	PLD1	3	171431715	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	5883851	171431715	26590715	89	851											
NLGN1	22871	broad.mit.edu	37	chr3	173322762	173322762	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagaatatcattgatggcaGattgccagaagtcatgcttc	12	11	9	9	0	2	4	2	1	0	3	3	4	2	4	2	1	2	2	2	1	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:173322762G>C	uc003fio.1	+	3	797	c.374G>C	c.(373-375)AGA>ACA	p.R125T	NLGN1_uc010hww.1_Missense_Mutation_p.R125T|NLGN1_uc003fip.1_Missense_Mutation_p.R125T	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	125	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			ATTGATGGCAGATTGCCAGAA	0.433													26	542					0	0	0	0	C	173322762	C	C	173322762	3	2	4	1	0	0	0	0	1	0	0	0	10515	942	33	2	376	2	NLGN1	3	173322762	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1891047	173322762	24699668	90	852											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			102	64					0	0	0	0	A	178936091	A	A	178936091	3	1	4	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	5613329	178936091	19086339	91	853											
BCL6	604	broad.mit.edu	37	chr3	187447044	187447044	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcattctggttgaggctgttGagcacgatgaacttgtattt	8	15	12	6	1	1	3	0	3	1	0	1	4	1	3	0	2	2	6	0	2	2	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:187447044G>A	uc003frp.3	-	5	1606	c.1149C>T	c.(1147-1149)CTC>CTT	p.L383L	BCL6_uc011bsf.1_Silent_p.L383L|BCL6_uc010hza.2_Silent_p.L281L|BCL6_uc003frq.1_Silent_p.L383L	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	383					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		TGAGGCTGTTGAGCACGATGA	0.607			T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								21	864					0	0	0	0	A	187447044	A	A	187447044	2	1	4	1	0	0	0	0	0	0	0	1	1378	1277	45	2		2	BCL6	3	187447044	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	8510953	187447044	10575386	92	854											
TFRC	7037	broad.mit.edu	37	chr3	195782122	195782122	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactcaggaatcctctcaatCagttccttataggtgtccat	11	13	6	11	0	3	0	3	0	1	0	7	1	6	1	3	2	1	1	3	2	5	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:195782122C>G	uc003fvz.3	-	17	2011	c.1728G>C	c.(1726-1728)CTG>CTC	p.L576L	TFRC_uc003fwa.3_Silent_p.L576L|TFRC_uc010hzy.2_Silent_p.L495L|TFRC_uc011btr.1_Silent_p.L294L	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	576	Extracellular (Potential).|Ligand-binding.				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		TCCTCTCAATCAGTTCCTTAT	0.468			T	BCL6	NHL								40	312					0	0	0	0	G	195782122	G	G	195782122	2	3	4	1	0	0	0	0	0	0	0	1	15878	813	29	2		2	TFRC	3	195782122	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	8335078	195782122	2240308	93	855											
LMLN	89782	broad.mit.edu	37	chr3	197712706	197712706	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcattctaccatgataaaGatggaaatcctctcacttca	13	13	5	10	0	3	2	2	1	2	1	5	3	4	3	2	1	2	1	2	1	4	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr3:197712706G>C	uc011buo.1	+	8	896	c.874G>C	c.(874-876)GAT>CAT	p.D292H	LMLN_uc003fyt.2_Missense_Mutation_p.D240H|LMLN_uc010iar.2_Missense_Mutation_p.D292H|LMLN_uc010ias.2_Missense_Mutation_p.D240H|LMLN_uc003fyu.2_Missense_Mutation_p.D52H	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	292					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CCATGATAAAGATGGAAATCC	0.403													26	278					0	0	0	0	C	197712706	C	C	197712706	3	2	4	1	0	0	0	0	1	0	0	0	8889	942	33	2	904	2	LMLN	3	197712706	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1930584	197712706	309724	94	856											
RGS12	6002	broad.mit.edu	37	chr4	3441262	3441262	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taactggctcggcgcccgggCgggatggtggcatagcgggg	5	6	20	10	5	0	0	0	0	0	0	1	1	0	1	1	8	2	2	1	8	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr4:3441262C>T	uc003ggw.2	+	18	5099	c.4195C>T	c.(4195-4197)CGG>TGG	p.R1399W	RGS12_uc003ggz.2_Missense_Mutation_p.R751W|RGS12_uc003gha.2_Missense_Mutation_p.R741W|RGS12_uc010icv.2_Missense_Mutation_p.R598W|HGFAC_uc003ghc.2_5'Flank|HGFAC_uc010icw.2_5'Flank	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1399						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGCGCCCGGGCGGGATGGTGG	0.647													21	32					0	0	0	0	T	3441262	T	T	3441262	3	4	4	1	0	0	0	0	1	0	0	0	13360	759	27	1	4336	1	RGS12	4	3441262	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08		3441262	187713014	95	857											
SDAD1	55153	broad.mit.edu	37	chr4	76886972	76886972	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaacagaaggatcttggttActtctgaaaacataagagaa	18	9	8	6	0	2	3	0	1	2	2	2	5	2	4	0	2	3	1	0	2	7	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr4:76886972A>G	uc003hje.3	-	13	1168	c.1049T>C	c.(1048-1050)GTA>GCA	p.V350A	SDAD1_uc003hjf.3_Missense_Mutation_p.V253A|SDAD1_uc011cbr.1_Missense_Mutation_p.V313A	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	350					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GATCTTGGTTACTTCTGAAAA	0.403													37	108					0	0	0	0	G	76886972	G	G	76886972	3	3	4	1	0	0	0	0	1	0	0	0	14015	391	14	5	1054	5	SDAD1	4	76886972	Missense_Mutation	SNP	A	TCGA-BA-4077-01B-01D-1434-08	73445710	76886972	114267304	96	858											
CCNG2	901	broad.mit.edu	37	chr4	78081937	78081939	+	In_Frame_Del	DEL	GAA	-	-																															tgctggctgctagaatagttGaagaagactgcaatattcca																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr4:78081937_78081939delGAA	uc003hkq.3	+	4	643_645	c.340_342delGAA	c.(340-342)GAAdel	p.E115del	CCNG2_uc003hkn.3_In_Frame_Del_p.E115del|CCNG2_uc011ccc.1_In_Frame_Del_p.E115del|CCNG2_uc003hkp.3_In_Frame_Del_p.E115del	NM_004354	NP_004345	Q16589	CCNG2_HUMAN	cyclin G2	115					cell cycle checkpoint|cell division|mitosis	cytoplasm				ovary(2)|lung(1)	3						TAGAATAGTTGAAGAAGACTGCA	0.365													---	---	---								-	78081939	-	-	78081937	7	5	4	1	0	1	0	1	0	0	0	0	2939	1291	45	0	350	0	CCNG2	4	78081937	In_Frame_Del	DEL	GAA	TCGA-BA-4077-01B-01D-1434-08	1194965	78081937	113072339	97	859											
PTPN13	5783	broad.mit.edu	37	chr4	87705639	87705639	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctggggaagaaataaatGaaatatcgtaccccaaagga	17	8	10	6	1	0	2	0	1	0	1	1	4	0	4	2	3	2	2	2	3	8	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr4:87705639G>A	uc003hpz.2	+	38	6526	c.6046G>A	c.(6046-6048)GAA>AAA	p.E2016K	PTPN13_uc003hpy.2_Missense_Mutation_p.E2021K|PTPN13_uc003hqa.2_Missense_Mutation_p.E1997K|PTPN13_uc003hqb.2_Missense_Mutation_p.E1825K|PTPN13_uc003hqc.1_Missense_Mutation_p.E382K	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2016						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AGAAATAAATGAAATATCGTA	0.378													4	37					0	0	0	0	A	87705639	A	A	87705639	3	1	4	1	0	0	0	0	1	0	0	0	12845	1291	45	2	6207	2	PTPN13	4	87705639	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	9623702	87705639	103448637	98	860											
SPATA5	166378	broad.mit.edu	37	chr4	123855341	123855341	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattgcgagtgaaaggggcaGatggcatgatattgggaggg	11	9	18	3	1	0	3	0	2	0	1	0	5	0	4	0	5	1	2	0	5	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr4:123855341G>A	uc003iez.3	+	5	668	c.595G>A	c.(595-597)GAT>AAT	p.D199N	SPATA5_uc003iey.2_Missense_Mutation_p.D198N	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	199					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						GAAAGGGGCAGATGGCATGAT	0.468													6	124					0	0	0	0	A	123855341	A	A	123855341	3	1	4	1	0	0	0	0	1	0	0	0	15077	942	33	2	613	2	SPATA5	4	123855341	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	36149702	123855341	67298935	99	861											
SLC10A7	84068	broad.mit.edu	37	chr4	147431156	147431156	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgcaagagtaaagatctGaataaaaagatgcagtttta	19	10	9	3	0	1	4	0	1	1	3	1	5	1	4	0	0	2	4	0	0	9	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr4:147431156G>T	uc010ioz.2	-	3	483	c.229C>A	c.(229-231)CAG>AAG	p.Q77K	SLC10A7_uc003ikr.2_Missense_Mutation_p.Q77K|SLC10A7_uc010ipa.2_Missense_Mutation_p.Q77K|SLC10A7_uc003iks.2_RNA|SLC10A7_uc003ikt.2_Missense_Mutation_p.Q77K	NM_001029998	NP_001025169	Q0GE19	NTCP7_HUMAN	solute carrier family 10 (sodium/bile acid	77	Helical; (Potential).					integral to membrane	bile acid:sodium symporter activity				0	all_hematologic(180;0.151)					GTAAAGATCTGAATAAAAAGA	0.353													29	50					1.30897e-18	1.43724e-18	1	0	T	147431156	T	T	147431156	3	4	4	1	0	0	0	0	1	0	0	0	14444	1299	45	2	878	2	SLC10A7	4	147431156	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	23575815	147431156	43723120	100	862											
ARFIP1	27236	broad.mit.edu	37	chr4	153784795	153784795	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accatctggacttggtctctCagaaacccaaattacatctc	12	11	5	13	0	4	1	1	0	3	1	6	2	4	2	2	2	2	0	2	2	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr4:153784795C>T	uc003imz.2	+	3	407	c.131C>T	c.(130-132)TCA>TTA	p.S44L	ARFIP1_uc003inb.2_Missense_Mutation_p.S44L|ARFIP1_uc003ina.2_Missense_Mutation_p.S44L|ARFIP1_uc003inc.2_Missense_Mutation_p.S44L|ARFIP1_uc011cij.1_Intron	NM_001025595	NP_001020766	P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	44					intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane				ovary(1)	1	all_hematologic(180;0.093)					CTTGGTCTCTCAGAAACCCAA	0.358													12	106					0	0	0	0	T	153784795	T	T	153784795	3	4	4	1	0	0	0	0	1	0	0	0	854	838	29	2	137	2	ARFIP1	4	153784795	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	6353639	153784795	37369481	101	863											
DCHS2	54798	broad.mit.edu	37	chr4	155252756	155252756	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcctaattcacagaacaGagacttgagaacaaaggctt	15	10	7	9	0	2	3	1	1	1	3	3	5	2	3	1	1	2	1	1	1	4	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr4:155252756G>C	uc003inw.2	-	10	2344	c.2344C>G	c.(2344-2346)CTG>GTG	p.L782V	DCHS2_uc003inx.2_Intron	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	782	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		tcacagaaCAGAGACTTGAGA	0.239													12	27					0	0	0	0	C	155252756	C	C	155252756	3	2	4	1	0	0	0	0	1	0	0	0	4305	933	33	2	6566	2	DCHS2	4	155252756	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1467961	155252756	35901520	102	864											
NPY5R	4889	broad.mit.edu	37	chr4	164271639	164271639	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctcatgaaaaagcgtaatCagaagactacggtaaacttc	16	9	7	9	2	2	3	2	1	1	2	4	3	2	3	0	1	3	2	0	1	7	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr4:164271639C>T	uc003iqn.2	+	4	396	c.214C>T	c.(214-216)CAG>TAG	p.Q72*		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	72	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				AAAGCGTAATCAGAAGACTAC	0.398													84	335					0	0	0	0	T	164271639	T	T	164271639	4	4	4	1	0	0	0	0	0	1	0	0	10664	827	29	2	216	2	NPY5R	4	164271639	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	9018883	164271639	26882637	103	865											
SORBS2	8470	broad.mit.edu	37	chr4	186545444	186545444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccgggatttgattttgggaGagacggtttcttccgtgctg	5	15	14	7	3	1	2	0	1	1	1	3	5	3	4	2	3	1	2	2	3	0	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr4:186545444G>A	uc003iyl.2	-	13	1985	c.1127C>T	c.(1126-1128)TCT>TTT	p.S376F	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.S476F|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.S280F|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.S490F|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	376						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GATTTTGGGAGAGACGGTTTC	0.537													42	77					0	0	0	0	A	186545444	A	A	186545444	3	1	4	1	0	0	0	0	1	0	0	0	14992	942	33	2	2211	2	SORBS2	4	186545444	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	22273805	186545444	4608832	104	866											
SDHA	6389	broad.mit.edu	37	chr5	226112	226112	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggcccatcggtgctgcTgtgtggctgatcggactggc	4	9	17	11	2	0	1	0	1	0	0	2	2	0	2	1	6	2	4	1	6	0	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:226112T>C	uc003jao.3	+	5	686	c.571T>C	c.(571-573)TGT>CGT	p.C191R	SDHA_uc003jan.2_Missense_Mutation_p.C191R|SDHA_uc011clv.1_Missense_Mutation_p.C191R|SDHA_uc011clw.1_Missense_Mutation_p.C143R|SDHA_uc003jap.3_Missense_Mutation_p.C191R|SDHA_uc003jaq.3_5'Flank	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	191					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	TCGGTGCTGCTGTGTGGCTGA	0.562									Familial_Paragangliomas				23	171					0	0	0	0	C	226112	C	C	226112	3	2	4	1	0	0	0	0	1	0	0	0	14028	1580	55	5	589	5	SDHA	5	226112	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08		226112	180689148	105	867											
DNAH5	1767	broad.mit.edu	37	chr5	13864529	13864529	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatttcctctttatatttcaGaagaggtgcctccatgatat	10	17	6	8	0	2	3	1	1	1	2	4	3	4	3	3	1	1	0	3	1	5	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:13864529G>A	uc003jfd.2	-	28	4615	c.4573C>T	c.(4573-4575)CTG>TTG	p.L1525L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1525	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTATATTTCAGAAGAGGTGCC	0.408									Kartagener_syndrome				13	176					0	0	0	0	A	13864529	A	A	13864529	2	1	4	1	0	0	0	0	0	0	0	1	4626	933	33	2		2	DNAH5	5	13864529	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	13638417	13864529	167050731	106	868											
GPBP1	65056	broad.mit.edu	37	chr5	56531816	56531816	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttaaatcctgagtatgaGagagaaccaaatcacaataa	18	10	6	7	0	2	3	1	2	1	2	3	5	3	3	2	0	1	1	2	0	7	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:56531816G>A	uc003jrh.3	+	6	1709	c.435G>A	c.(433-435)GAG>GAA	p.E145E	GPBP1_uc010iwg.2_Silent_p.E145E|GPBP1_uc003jri.3_5'UTR|GPBP1_uc003jrj.3_Silent_p.E152E|GPBP1_uc003jrk.3_Silent_p.E152E|GPBP1_uc003jrl.3_RNA	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		CTGAGTATGAGAGAGAACCAA	0.318													9	136					0	0	0	0	A	56531816	A	A	56531816	2	1	4	1	0	0	0	0	0	0	0	1	6633	933	33	2		2	GPBP1	5	56531816	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	42667287	56531816	124383444	107	869											
PLK2	10769	broad.mit.edu	37	chr5	57755707	57755707	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcttcttcttcgagtccgctCcgcaacccttgcccagcgcc	4	10	8	19	4	2	0	0	0	2	0	5	1	4	0	5	0	3	3	5	0	1	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:57755707C>T	uc003jrn.2	-	1	207	c.80G>A	c.(79-81)GGA>GAA	p.G27E	PLK2_uc011cql.1_5'Flank	NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	27					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		CGAGTCCGCTCCGCAACCCTT	0.682													4	35					0	0	0	0	T	57755707	T	T	57755707	3	4	4	1	0	0	0	0	1	0	0	0	12151	855	30	2	2033	2	PLK2	5	57755707	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1223891	57755707	123159553	108	870											
ERCC8	1161	broad.mit.edu	37	chr5	60183269	60183269	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgaaaataatatttacctCatcatcatcaggaactggtt	14	14	6	7	0	4	1	4	1	0	0	4	2	4	2	1	2	2	1	1	2	6	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:60183269C>G	uc003jsm.3	-	11	1190	c.1120G>C	c.(1120-1122)GAG>CAG	p.E374Q	ERCC8_uc003jsk.2_RNA|ERCC8_uc003jsl.3_Missense_Mutation_p.E316Q|ERCC8_uc011cqp.1_Missense_Mutation_p.E221Q	NM_000082	NP_000073	Q13216	ERCC8_HUMAN	excision repair cross-complementing rodent	374					positive regulation of DNA repair|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein polyubiquitination|response to oxidative stress|response to UV|response to UV|transcription-coupled nucleotide-excision repair	Cul4A-RING ubiquitin ligase complex|nuclear matrix|nucleoplasm|nucleotide-excision repair complex|soluble fraction	protein binding|protein complex binding				0		Lung NSC(810;1.51e-06)|Prostate(74;0.0322)|Ovarian(174;0.0481)|Breast(144;0.077)				ATATTTACCTCATCATCATCA	0.343								Direct_reversal_of_damage|NER					33	96					0	0	0	0	G	60183269	G	G	60183269	3	3	4	1	0	0	0	0	1	0	0	0	5243	835	29	2	78	2	ERCC8	5	60183269	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2427562	60183269	120731991	109	871											
HTR1A	3350	broad.mit.edu	37	chr5	63256428	63256428	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agggtgggcatgtggcagctGctctcgcagaagggcagaac	9	6	17	9	1	1	2	0	0	1	2	2	2	1	2	0	4	3	6	0	4	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:63256428G>A	uc011cqt.1	-	1	1119	c.1119C>T	c.(1117-1119)AGC>AGT	p.S373S		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	373	Extracellular (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TGTGGCAGCTGCTCTCGCAGA	0.542													94	167					0	0	0	0	A	63256428	A	A	63256428	2	1	4	1	0	0	0	0	0	0	0	1	7475	1310	46	4		4	HTR1A	5	63256428	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	3073159	63256428	117658832	110	872											
SGTB	54557	broad.mit.edu	37	chr5	65008794	65008794	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taatgacaacataccttacaGaaggaactggtaaacatttc	17	10	6	8	0	0	2	0	1	0	1	1	3	0	3	1	2	5	1	1	2	8	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:65008794G>A	uc003jud.2	-	3	418	c.198C>T	c.(196-198)TTC>TTT	p.F66F		NM_019072	NP_061945	Q96EQ0	SGTB_HUMAN	small glutamine-rich tetratricopeptide repeat	66							binding				0		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Breast(144;0.174)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0657)|Lung(70;0.00487)		ATACCTTACAGAAGGAACTGG	0.353													3	116					0	0	0	0	A	65008794	A	A	65008794	2	1	4	1	0	0	0	0	0	0	0	1	14291	933	33	2		2	SGTB	5	65008794	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1752366	65008794	115906466	111	873											
SPZ1	84654	broad.mit.edu	37	chr5	79616896	79616896	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttggaaataatggagtcGgtttccaaacccagccaaat	13	10	8	10	1	1	0	0	0	1	0	3	2	2	2	3	3	2	1	3	3	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:79616896G>A	uc003kgn.2	+	1	1107	c.862G>A	c.(862-864)GGT>AGT	p.G288S	uc011ctk.1_RNA	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	288					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		TAATGGAGTCGGTTTCCAAAC	0.413													51	70					0	0	0	0	A	79616896	A	A	79616896	3	1	4	1	0	0	0	0	1	0	0	0	15193	1116	39	1	864	1	SPZ1	5	79616896	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	14608102	79616896	101298364	112	874											
SPZ1	84654	broad.mit.edu	37	chr5	79617264	79617264	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagcttgcaatacccagttCaatattcatgttgcaagaaa	16	11	6	8	0	2	1	2	0	0	1	2	1	2	1	1	0	4	5	1	0	7	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:79617264C>G	uc003kgn.2	+	1	1475	c.1230C>G	c.(1228-1230)TTC>TTG	p.F410L	uc011ctk.1_RNA	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		ATACCCAGTTCAATATTCATG	0.378													24	86					0	0	0	0	G	79617264	G	G	79617264	3	3	4	1	0	0	0	0	1	0	0	0	15193	825	29	2	1232	2	SPZ1	5	79617264	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	368	79617264	101297996	113	875											
RASGRF2	5924	broad.mit.edu	37	chr5	80390809	80390809	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggatgagtgacatcagtCaggtaagaaagtggcttttg	11	11	13	6	0	2	3	2	2	0	1	2	4	2	4	1	3	0	2	1	3	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:80390809C>G	uc003kha.1	+	12	1753	c.1753C>G	c.(1753-1755)CAG>GAG	p.Q585E	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	585	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TGACATCAGTCAGGTAAGAAA	0.383													14	75					0	0	0	0	G	80390809	G	G	80390809	3	3	4	1	0	0	0	0	1	0	0	0	13138	827	29	2	1799	2	RASGRF2	5	80390809	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	773545	80390809	100524451	114	876											
DCP2	167227	broad.mit.edu	37	chr5	112337070	112337070	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagaacattgagtggttctCtattgagaaattgccttgtc	10	15	9	7	0	2	3	1	2	1	2	4	4	2	3	1	1	2	1	1	1	3	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:112337070C>G	uc003kqh.2	+	6	800	c.602C>G	c.(601-603)TCT>TGT	p.S201C	DCP2_uc011cwa.1_5'UTR|DCP2_uc010jcc.2_Missense_Mutation_p.S107C	NM_152624	NP_689837	Q8IU60	DCP2_HUMAN	DCP2 decapping enzyme	201	Nudix hydrolase.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|protein binding|RNA binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		GAGTGGTTCTCTATTGAGAAA	0.333													40	167					0	0	0	0	G	112337070	G	G	112337070	3	3	4	1	0	0	0	0	1	0	0	0	4317	913	32	2	624	2	DCP2	5	112337070	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	31946261	112337070	68578190	115	877											
PCDHA9	9752	broad.mit.edu	37	chr5	140230180	140230180	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggatgtcaacgtgtacctGatcatcgccatctgcgcggt	7	11	12	11	4	3	1	2	1	1	0	4	2	3	2	2	2	3	1	2	2	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:140230180G>A	uc003lhu.2	+	1	2824	c.2100G>A	c.(2098-2100)CTG>CTA	p.L700L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.L700L	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	700	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGTGTACCTGATCATCGCCA	0.662													7	103					0	0	0	0	A	140230180	A	A	140230180	2	1	4	1	0	0	0	0	0	0	0	1	11585	1277	45	2		2	PCDHA9	5	140230180	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	27893110	140230180	40685080	116	878											
PCDHB4	56131	broad.mit.edu	37	chr5	140502348	140502348	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcctggaaaacagccccctAgactctccaattgttagggt	10	10	9	12	0	1	1	0	0	1	1	3	2	2	2	4	2	2	1	4	2	5	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:140502348A>G	uc003lip.1	+	1	768	c.768A>G	c.(766-768)CTA>CTG	p.L256L		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	256	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAGCCCCCTAGACTCTCCAA	0.448													57	161					0	0	0	0	G	140502348	G	G	140502348	2	3	4	1	0	0	0	0	0	0	0	1	11598	407	15	5		5	PCDHB4	5	140502348	Silent	SNP	A	TCGA-BA-4077-01B-01D-1434-08	272168	140502348	40412912	117	879											
PCDHGC5	56097	broad.mit.edu	37	chr5	140868963	140868963	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggaatgttgctcaggatctGggcttaaagatgacagatct	11	11	13	6	0	3	3	1	1	2	2	3	5	3	5	0	3	1	3	0	3	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:140868963G>C	uc003lla.1	+	1	156	c.156G>C	c.(154-156)CTG>CTC	p.L52L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc003lky.1_Intron|PCDHGC5_uc011dbc.1_Silent_p.L52L	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	52	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCAGGATCTGGGCTTAAAGA	0.582													13	98					0	0	0	0	C	140868963	C	C	140868963	2	2	4	1	0	0	0	0	0	0	0	1	11625	1335	47	4		4	PCDHGC5	5	140868963	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	366615	140868963	40046297	118	880											
DIAPH1	1729	broad.mit.edu	37	chr5	140955833	140955833	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagctttggcttcagatttCtccacctttgtcttatcaat	7	17	6	11	0	4	1	2	0	2	1	5	1	4	1	2	1	1	3	2	1	2	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:140955833C>G	uc003llb.3	-	14	1566	c.1425G>C	c.(1423-1425)GAG>GAC	p.E475D	DIAPH1_uc003llc.3_Missense_Mutation_p.E466D|DIAPH1_uc010jgc.1_5'Flank	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	475	Potential.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCAGATTTCTCCACCTTTG	0.363													36	145					0	0	0	0	G	140955833	G	G	140955833	3	3	4	1	0	0	0	0	1	0	0	0	4540	912	32	2	2453	2	DIAPH1	5	140955833	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	86870	140955833	39959427	119	881											
RGS14	10636	broad.mit.edu	37	chr5	176795809	176795809	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctgcccgatggcacagcctCcttggccctggccagacctg	5	7	11	18	1	0	1	0	0	0	1	1	2	1	1	7	3	2	1	7	3	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr5:176795809C>T	uc003mgf.2	+	9	1123	c.941C>T	c.(940-942)TCC>TTC	p.S314F	RGS14_uc003mgg.1_Missense_Mutation_p.S161F|RGS14_uc003mgh.2_Missense_Mutation_p.S161F|RGS14_uc003mgi.2_Missense_Mutation_p.S84F|RGS14_uc003mgj.2_5'Flank	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	314	Necessary for interaction with RABGEF1 (By similarity).|RBD 1.				chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCACAGCCTCCTTGGCCCTG	0.592											OREG0017086	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	41					0	0	0	0	T	176795809	T	T	176795809	3	4	4	1	0	0	0	0	1	0	0	0	13362	855	30	2	975	2	RGS14	5	176795809	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	35839976	176795809	4119451	120	882											
HIST1H1B	3009	broad.mit.edu	37	chr6	27834627	27834627	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttttcacacgccagcttcCtacttctttttggcagccgc	5	14	8	14	2	2	0	1	0	1	0	3	0	3	0	3	2	3	3	3	2	1	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:27834627C>T	uc003njx.2	-	1	733	c.681G>A	c.(679-681)TAG>TAA	p.*227*		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	227					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CGCCAGCTTCCTACTTCTTTT	0.517													15	23					0	0	0	0	T	27834627	T	T	27834627	2	4	4	1	0	0	0	0	0	0	0	1	7162	692	24	4		4	HIST1H1B	6	27834627	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08		27834627	143280440	121	883											
BAT2	7916	broad.mit.edu	37	chr6	31597336	31597336	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttcctaggagcagctcctGaagcagcagcagcagcacca	11	6	10	14	0	0	1	0	1	0	0	2	2	2	2	3	1	7	7	3	1	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:31597336G>A	uc003nvb.3	+	14	2217	c.1968G>A	c.(1966-1968)CTG>CTA	p.L656L	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Silent_p.L656L	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	656	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						AGCAGCTCCTGAagcagcagc	0.443													145	239					0	0	0	0	A	31597336	A	A	31597336	2	1	4	1	0	0	0	0	0	0	0	1	1321	1277	45	2		2	BAT2	6	31597336	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	3762709	31597336	139517731	122	884											
RXRB	6257	broad.mit.edu	37	chr6	33165572	33165572	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccagtggccaggcacttctGatagcggcagtactgacagc	9	7	13	12	1	1	2	0	2	1	0	1	2	1	2	2	3	3	3	2	3	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:33165572G>A	uc003odb.2	-	4	966	c.787C>T	c.(787-789)CAG>TAG	p.Q263*	RXRB_uc003odc.2_Nonsense_Mutation_p.Q263*|RXRB_uc003odd.2_Nonsense_Mutation_p.Q167*|RXRB_uc011dqr.1_Nonsense_Mutation_p.Q73*|RXRB_uc011dqs.1_Nonsense_Mutation_p.Q146*|RXRB_uc003ode.1_Nonsense_Mutation_p.Q127*|RXRB_uc011dqt.1_Nonsense_Mutation_p.Q263*|RXRB_uc011dqu.1_Nonsense_Mutation_p.Q167*	NM_021976	NP_068811	P28702	RXRB_HUMAN	retinoid X receptor, beta	263	NR C4-type.|Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			ovary(3)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Bexarotene(DB00307)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	AGGCACTTCTGATAGCGGCAG	0.577													6	69					0	0	0	0	A	33165572	A	A	33165572	4	1	4	1	0	0	0	0	0	1	0	0	13829	1299	45	2	842	2	RXRB	6	33165572	Nonsense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1568236	33165572	137949495	123	885											
SLC26A8	116369	broad.mit.edu	37	chr6	35980010	35980010	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcttcatatcttccttacCttggggaacttgcacaaggc	9	12	9	11	0	2	0	1	0	1	0	3	1	3	1	2	4	3	2	2	4	4	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:35980010C>G	uc003olm.2	-	3	439	c.328G>C	c.(328-330)GGC>CGC	p.G110R	SLC26A8_uc003oln.2_Missense_Mutation_p.G110R|SLC26A8_uc003oll.2_Missense_Mutation_p.G110R	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	110	Helical; (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						TCTTCCTTACCTTGGGGAACT	0.418													28	454					0	0	0	0	G	35980010	G	G	35980010	3	3	4	1	0	0	0	0	1	0	0	0	14587	695	24	4	2656	4	SLC26A8	6	35980010	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2814438	35980010	135135057	124	886											
HCRTR2	3062	broad.mit.edu	37	chr6	55113511	55113511	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtcaatctttctctggctGatgtgctcgtgaccatcacc	7	14	8	12	1	4	2	2	2	2	0	6	2	4	2	2	1	1	2	2	1	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:55113511G>T	uc003pcl.2	+	2	613	c.298G>T	c.(298-300)GAT>TAT	p.D100Y	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.D35Y	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	100	Helical; Name=2; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTCTCTGGCTGATGTGCTCGT	0.453													32	235					6.00712e-18	6.57923e-18	1	0	T	55113511	T	T	55113511	3	4	4	1	0	0	0	0	1	0	0	0	7041	1290	45	2	304	2	HCRTR2	6	55113511	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	19133501	55113511	116001556	125	887											
DST	667	broad.mit.edu	37	chr6	56458614	56458614	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagaaattgtgatgtatctCaagtcacctttgtgagaaat	13	13	8	7	0	2	3	2	2	1	2	3	4	2	3	2	0	0	1	2	0	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:56458614C>T	uc003pdf.2	-	42	6244	c.6216G>A	c.(6214-6216)TTG>TTA	p.L2072L	DST_uc003pcz.3_Silent_p.L1894L|DST_uc011dxj.1_Silent_p.L1923L|DST_uc011dxk.1_Silent_p.L1934L|DST_uc003pcy.3_Silent_p.L1568L|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	3980	Spectrin 2.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGATGTATCTCAAGTCACCTT	0.438													37	364					0	0	0	0	T	56458614	T	T	56458614	2	4	4	1	0	0	0	0	0	0	0	1	4805	825	29	2		2	DST	6	56458614	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1345103	56458614	114656453	126	888											
EEF1A1	1915	broad.mit.edu	37	chr6	74229717	74229717	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaatctacgtgtccaatgacGacaatgttgatatgagtctt	12	13	9	7	2	2	3	0	3	2	0	3	5	3	3	1	0	1	1	1	0	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:74229717G>A	uc003phi.2	-	1	70	c.33C>T	c.(31-33)GTC>GTT	p.V11V	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Silent_p.V11V|EEF1A1_uc003phf.2_Silent_p.V11V|EEF1A1_uc003phg.2_Silent_p.V11V|EEF1A1_uc003phh.2_5'UTR|EEF1A1_uc003phj.2_Silent_p.V11V|EEF1A1_uc003phk.2_Silent_p.V11V|EEF1A1_uc003phl.2_Silent_p.V11V|EEF1A1_uc003phm.1_RNA	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	11						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						GTCCAATGACGACAATGTTGA	0.418													15	127					0	0	0	0	A	74229717	A	A	74229717	2	1	4	1	0	0	0	0	0	0	0	1	4945	1045	37	1		1	EEF1A1	6	74229717	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	17771103	74229717	96885350	127	889											
GABRR2	2570	broad.mit.edu	37	chr6	89974233	89974233	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgaacacaaagctgacccaGaggtagatgtccacggcctt	13	6	10	12	2	0	3	0	1	0	2	1	4	1	3	3	2	2	2	3	2	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:89974233G>C	uc003pnb.2	-	8	1067	c.1059C>G	c.(1057-1059)CTC>CTG	p.L353L	GABRR2_uc011dzx.1_Silent_p.L229L	NM_002043	NP_002034	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 2	353	Helical; (Potential).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		AGCTGACCCAGAGGTAGATGT	0.592													22	95					0	0	0	0	C	89974233	C	C	89974233	2	2	4	1	0	0	0	0	0	0	0	1	6211	929	33	2		2	GABRR2	6	89974233	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	15744516	89974233	81140834	128	890											
MDN1	23195	broad.mit.edu	37	chr6	90494802	90494802	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgtctagcaaagtagcatGactgtttagcggtcgatacc	10	13	10	8	2	1	1	0	1	1	0	2	2	1	1	1	1	4	4	1	1	5	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:90494802G>C	uc003pnn.1	-	9	1494	c.1378C>G	c.(1378-1380)CAT>GAT	p.H460D	MDN1_uc003pno.1_5'UTR|MDN1_uc003pnp.1_Missense_Mutation_p.H460D	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	460					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AAAGTAGCATGACTGTTTAGC	0.378													6	344					0	0	0	0	C	90494802	C	C	90494802	3	2	4	1	0	0	0	0	1	0	0	0	9468	1290	45	2	15788	2	MDN1	6	90494802	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	520569	90494802	80620265	129	891											
MAP3K5	4217	broad.mit.edu	37	chr6	136888996	136888996	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcactctcagatgcaaggctGaaatgtggccttagttctgt	9	13	10	9	0	3	2	2	1	2	1	4	2	3	2	1	2	1	3	1	2	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:136888996G>A	uc003qhc.2	-	26	3895	c.3534C>T	c.(3532-3534)TTC>TTT	p.F1178F	MAP3K5_uc011edj.1_Silent_p.F425F|MAP3K5_uc011edk.1_Silent_p.F1024F	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	1178					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		ATGCAAGGCTGAAATGTGGCC	0.373													48	106					0	0	0	0	A	136888996	A	A	136888996	2	1	4	1	0	0	0	0	0	0	0	1	9306	1281	45	2		2	MAP3K5	6	136888996	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	46394194	136888996	34226071	130	892											
FNDC1	84624	broad.mit.edu	37	chr6	159659662	159659662	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcacatggaaatcctcttcGgattaaactaggaggagatg	13	11	10	7	1	2	1	1	0	1	1	4	5	3	4	1	4	1	0	1	4	4	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:159659662G>A	uc010kjv.2	+	13	4345	c.4145G>A	c.(4144-4146)CGG>CAG	p.R1382Q	FNDC1_uc010kjw.1_Missense_Mutation_p.R1267Q	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1382						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AATCCTCTTCGGATTAAACTA	0.388													8	20					0	0	0	0	A	159659662	A	A	159659662	3	1	4	1	0	0	0	0	1	0	0	0	6000	1116	39	1	4195	1	FNDC1	6	159659662	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	22770666	159659662	11455405	131	893											
WTAP	9589	broad.mit.edu	37	chr6	160176375	160176375	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgactttccttcttctccagGgaatggtaataagtcctcca	9	14	7	11	0	2	1	0	1	2	0	6	2	5	2	4	2	0	1	4	2	3	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:160176375G>A	uc003qsl.2	+	8	1145	c.923G>A	c.(922-924)GGG>GAG	p.G308E	WTAP_uc003qso.2_Missense_Mutation_p.G189E	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	308					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		TCTTCTCCAGGGAATGGTAAT	0.507													30	71					0	0	0	0	A	160176375	A	A	160176375	3	1	4	1	0	0	0	0	1	0	0	0	17477	1232	43	4	953	4	WTAP	6	160176375	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	516713	160176375	10938692	132	894											
TCP1	6950	broad.mit.edu	37	chr6	160200096	160200096	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaatcattaagggctccaGagtgaacagcatcttcataa	15	10	7	9	0	4	2	3	1	1	1	5	2	5	2	1	1	2	2	1	1	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:160200096G>A	uc003qsr.2	-	12	1887	c.1652C>T	c.(1651-1653)TCT>TTT	p.S551F	TCP1_uc003qss.2_Missense_Mutation_p.S396F|TCP1_uc010kjz.2_3'UTR|TCP1_uc003qst.2_Missense_Mutation_p.S327F	NM_030752	NP_110379	P17987	TCPA_HUMAN	T-complex protein 1 isoform a	551					'de novo' posttranslational protein folding|tubulin complex assembly	cell junction|Golgi apparatus	ATP binding|unfolded protein binding			breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(65;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		AAGGGCTCCAGAGTGAACAGC	0.318													22	90					0	0	0	0	A	160200096	A	A	160200096	3	1	4	1	0	0	0	0	1	0	0	0	15775	942	33	2	22	2	TCP1	6	160200096	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	23721	160200096	10914971	133	895											
PLG	5340	broad.mit.edu	37	chr6	161134091	161134092	+	Missense_Mutation	DNP	GG	AA	AA																															atccagacaacgatccgcagGggccctggtgctatactact																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:161134091_161134092GG>AA	uc003qtm.3	+	5	544_545	c.481_482GG>AA	c.(481-483)GGG>AAG	p.G161K		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	161	Kringle 1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CGATCCGCAGGGGCCCTGGTGC	0.48													74	154					0	0	0	0	AA	161134092	AA	AA	161134091	3	1	4	1	0	0	0	0	1	0	0	0	12141	1232	43	4	503	4	PLG	6	161134091	Missense_Mutation	DNP	GG	TCGA-BA-4077-01B-01D-1434-08	933995	161134091	9980976	134	896											
MLLT4	4301	broad.mit.edu	37	chr6	168276155	168276155	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgcaggaatttcggagctCagatgggcggcctgattcag	10	9	14	8	2	2	2	2	1	0	1	3	4	2	4	1	4	2	2	1	4	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:168276155C>G	uc003qwd.2	+	5	858	c.716C>G	c.(715-717)TCA>TGA	p.S239*	MLLT4_uc003qwb.1_Nonsense_Mutation_p.S239*|MLLT4_uc003qwc.1_Nonsense_Mutation_p.S240*	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	240					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TTTCGGAGCTCAGATGGGCGG	0.438			T	MLL	AL								53	341					0	0	0	0	G	168276155	G	G	168276155	4	3	4	1	0	0	0	0	0	1	0	0	9682	838	29	2	737	2	MLLT4	6	168276155	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	7142064	168276155	2838912	135	897											
SMOC2	64094	broad.mit.edu	37	chr6	169053734	169053734	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtggagacatcggcaaaaagGaaatcaaacccttcaagagg	17	5	11	8	1	2	2	2	0	0	2	3	4	2	3	1	4	1	1	1	4	5	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr6:169053734G>A	uc003qws.1	+	11	1131	c.1111G>A	c.(1111-1113)GAA>AAA	p.E371K	SMOC2_uc003qwr.1_Missense_Mutation_p.E382K|SMOC2_uc011egu.1_Missense_Mutation_p.E48K	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	371	EF-hand 1.|1 (Potential).				signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		CGGCAAAAAGGAAATCAAACC	0.443													34	103					0	0	0	0	A	169053734	A	A	169053734	3	1	4	1	0	0	0	0	1	0	0	0	14866	1175	41	2	1186	2	SMOC2	6	169053734	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	777579	169053734	2061333	136	898											
USP42	84132	broad.mit.edu	37	chr7	6193669	6193669	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gggagcttaacaggcgatgcGagcccgttgtcccaggacgc	8	6	15	12	4	0	0	0	0	0	0	1	4	1	2	2	3	4	2	2	3	1	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:6193669G>C	uc011jwo.1	+	15	2607	c.2484G>C	c.(2482-2484)GCG>GCC	p.A828A	USP42_uc011jwp.1_Silent_p.A828A|USP42_uc011jwq.1_Silent_p.A635A|USP42_uc011jwr.1_Silent_p.A673A	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	828	Pro-rich.				cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		CAGGCGATGCGAGCCCGTTGT	0.716													9	66					0	0	0	0	C	6193669	C	C	6193669	2	2	4	1	0	0	0	0	0	0	0	1	17141	1045	37	3		3	USP42	7	6193669	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08		6193669	152944994	137	899											
HIBADH	11112	broad.mit.edu	37	chr7	27689115	27689115	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcacctgcatcttgaaactCtttgcaggcatcagggaaca	11	11	8	11	0	4	1	2	1	2	0	4	2	4	2	1	2	4	3	1	2	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:27689115C>T	uc003szf.2	-	2	424	c.229G>A	c.(229-231)GAG>AAG	p.E77K	HIBADH_uc003szg.2_Missense_Mutation_p.E28K|HIBADH_uc003szh.2_Intron|HIBADH_uc003szi.2_Missense_Mutation_p.E28K	NM_152740	NP_689953	P31937	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase precursor	77					branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			ovary(2)	2			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)	TCTTGAAACTCTTTGCAGGCA	0.353													26	49					0	0	0	0	T	27689115	T	T	27689115	3	4	4	1	0	0	0	0	1	0	0	0	7138	922	32	2	809	2	HIBADH	7	27689115	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	21495446	27689115	131449548	138	900											
NEUROD6	63974	broad.mit.edu	37	chr7	31378495	31378495	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaagtctctattttggacaGtttctgggttttagaataac	11	17	8	5	0	2	1	0	0	2	1	3	2	2	2	0	2	1	2	0	2	6	8			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:31378495G>C	uc003tch.2	-	2	741	c.388C>G	c.(388-390)CTG>GTG	p.L130V		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	130	Helix-loop-helix motif.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						ATTTTGGACAGTTTCTGGGTT	0.483													41	77					0	0	0	0	C	31378495	C	C	31378495	3	2	4	1	0	0	0	0	1	0	0	0	10405	1020	36	4	629	4	NEUROD6	7	31378495	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	3689380	31378495	127760168	139	901											
CAMK2B	816	broad.mit.edu	37	chr7	44281890	44281890	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggtcagcatctggttgAtgaggtttttggcttcagga	7	15	14	5	0	3	3	2	3	1	0	3	4	3	4	0	5	1	4	0	5	0	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:44281890A>G	uc003tkq.2	-	10	956	c.746T>C	c.(745-747)ATC>ACC	p.I249T	CAMK2B_uc003tkp.2_Missense_Mutation_p.I249T|CAMK2B_uc003tkx.2_Missense_Mutation_p.I249T|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.I249T|CAMK2B_uc003tks.2_Missense_Mutation_p.I249T|CAMK2B_uc003tku.2_Missense_Mutation_p.I249T|CAMK2B_uc003tkv.2_Missense_Mutation_p.I249T|CAMK2B_uc003tkt.2_Missense_Mutation_p.I249T|CAMK2B_uc003tkw.2_Missense_Mutation_p.I249T|CAMK2B_uc010kyc.2_Missense_Mutation_p.I249T	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	249	Protein kinase.				interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						CATCTGGTTGATGAGGTTTTT	0.627													45	95					0	0	0	0	G	44281890	G	G	44281890	3	3	4	1	0	0	0	0	1	0	0	0	2612	333	12	5	1313	5	CAMK2B	7	44281890	Missense_Mutation	SNP	A	TCGA-BA-4077-01B-01D-1434-08	12903395	44281890	114856773	140	902											
ZNF273	10793	broad.mit.edu	37	chr7	64363754	64363754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttacctgcaggtattgggaGatccacagctaagacgccag	11	8	12	10	1	0	2	0	0	0	2	1	3	1	2	3	2	3	4	3	2	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:64363754G>A	uc003tto.2	+	1	135	c.59G>A	c.(58-60)AGA>AAA	p.R20K	ZNF273_uc003ttl.2_Intron|ZNF273_uc003ttm.1_RNA|ZNF273_uc003ttn.2_5'UTR|ZNF273_uc003ttp.1_Intron	NM_021148	NP_066971	Q14593	ZN273_HUMAN	zinc finger protein 273	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(55;0.0295)|all_lung(88;0.0691)				GGTATTGGGAGATCCACAGCT	0.597													49	90					0	0	0	0	A	64363754	A	A	64363754	3	1	4	1	0	0	0	0	1	0	0	0	17875	942	33	2	61	2	ZNF273	7	64363754	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	20081864	64363754	94774909	141	903											
ZNF273	10793	broad.mit.edu	37	chr7	64388515	64388515	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atgtgaagaatgtggcaaagCctttaaccagtccttaactc	13	11	8	9	0	0	2	0	1	0	1	2	2	1	2	3	1	3	1	3	1	5	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:64388515C>T	uc003tto.2	+	4	885	c.809C>T	c.(808-810)GCC>GTC	p.A270V	ZNF273_uc003ttl.2_Missense_Mutation_p.A205V|ZNF273_uc003ttn.2_Missense_Mutation_p.A205V	NM_021148	NP_066971	Q14593	ZN273_HUMAN	zinc finger protein 273	270	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(55;0.0295)|all_lung(88;0.0691)				TGTGGCAAAGCCTTTAACCAG	0.328													35	76					0	0	0	0	T	64388515	T	T	64388515	3	4	4	1	0	0	0	0	1	0	0	0	17875	739	26	4	823	4	ZNF273	7	64388515	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	24761	64388515	94750148	142	904											
GNAI1	2770	broad.mit.edu	37	chr7	79764544	79764544	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagatgatcgaccgcaaccTccgtgaggacggcgagaagg	12	5	14	10	5	0	4	0	2	0	2	2	7	1	5	3	3	1	1	3	3	3	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:79764544T>C	uc003uhb.1	+	1	405	c.68T>C	c.(67-69)CTC>CCC	p.L23P	GNAI1_uc011kgt.1_5'Flank	NM_002069	NP_002060	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein),	23					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GACCGCAACCTCCGTGAGGAC	0.522													9	12					0	0	0	0	C	79764544	C	C	79764544	3	2	4	1	0	0	0	0	1	0	0	0	6541	1551	54	5	70	5	GNAI1	7	79764544	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	15376029	79764544	79374119	143	905											
GNAT3	346562	broad.mit.edu	37	chr7	80091924	80091924	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccacttctttctctcagatCtctgtccacctacatcaaac	9	14	2	16	0	5	1	2	0	3	1	9	1	7	1	3	0	2	0	3	0	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:80091924C>G	uc011kgu.1	-	6	614	c.614G>C	c.(613-615)AGA>ACA	p.R205T	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	205					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						TCTCTCAGATCTCTGTCCACC	0.373													5	101					0	0	0	0	G	80091924	G	G	80091924	3	3	4	1	0	0	0	0	1	0	0	0	6550	913	32	2	460	2	GNAT3	7	80091924	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	327380	80091924	79046739	144	906											
ABCB1	5243	broad.mit.edu	37	chr7	87214929	87214929	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcatgagaggaagtccagccCcatggatgatggcagccaaa	13	6	12	10	0	1	2	1	2	0	1	2	5	2	4	4	3	2	1	4	3	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:87214929C>T	uc003uiz.1	-	5	603	c.185G>A	c.(184-186)GGG>GAG	p.G62E	ABCB1_uc011khc.1_Missense_Mutation_p.G62E	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	62	ABC transmembrane type-1 1.|Helical; (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AAGTCCAGCCCCATGGATGAT	0.393													26	58					0	0	0	0	T	87214929	T	T	87214929	3	4	4	1	0	0	0	0	1	0	0	0	40	623	22	4	3757	4	ABCB1	7	87214929	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	7123005	87214929	71923734	145	907											
STAG3	10734	broad.mit.edu	37	chr7	99778218	99778218	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagctgtgggagataccaaGagggccttgtctgcatcttc	9	10	13	9	0	2	3	0	0	2	3	3	4	2	3	2	2	3	2	2	2	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:99778218G>C	uc003utx.1	+	2	194	c.39G>C	c.(37-39)AAG>AAC	p.K13N	STAG3_uc010lgs.1_5'UTR|STAG3_uc011kjk.1_Missense_Mutation_p.K13N	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	13					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAGATACCAAGAGGGCCTTGT	0.522													135	276					0	0	0	0	C	99778218	C	C	99778218	3	2	4	1	0	0	0	0	1	0	0	0	15310	933	33	2	41	2	STAG3	7	99778218	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	12563289	99778218	59360445	146	908											
MUC17	140453	broad.mit.edu	37	chr7	100678729	100678729	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttaacaagtatacctgtCaacaccacactggtggccag	12	9	7	13	0	1	0	1	0	0	0	1	0	1	0	4	2	3	1	4	2	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:100678729C>G	uc003uxp.1	+	3	4085	c.4032C>G	c.(4030-4032)GTC>GTG	p.V1344V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1344	Extracellular (Potential).|20.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTATACCTGTCAACACCACAC	0.458													134	293					0	0	0	0	G	100678729	G	G	100678729	2	3	4	1	0	0	0	0	0	0	0	1	10027	813	29	2		2	MUC17	7	100678729	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	900511	100678729	58459934	147	909											
FBXL13	222235	broad.mit.edu	37	chr7	102665558	102665558	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaatgtcacattttagagtCtcatctacaagaaagacttc	15	12	6	8	0	3	3	2	0	2	3	5	4	3	3	0	0	1	0	0	0	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:102665558C>G	uc003vaq.2	-	6	874	c.447G>C	c.(445-447)GAG>GAC	p.E149D	FBXL13_uc010liq.1_5'UTR|FBXL13_uc010lir.1_Missense_Mutation_p.E149D|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.E149D|FBXL13_uc003vav.2_RNA	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	149											0						ATTTTAGAGTCTCATCTACAA	0.289													6	36					0	0	0	0	G	102665558	G	G	102665558	3	3	4	1	0	0	0	0	1	0	0	0	5741	912	32	2	1820	2	FBXL13	7	102665558	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1986829	102665558	56473105	148	910											
MLL5	55904	broad.mit.edu	37	chr7	104702697	104702697	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccagcagctcacatcattCacacagttacattggtttgc	11	12	6	12	0	3	0	3	0	0	0	3	0	3	0	1	1	5	4	1	1	2	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:104702697C>T	uc003vcm.2	+	4	692	c.158C>T	c.(157-159)TCA>TTA	p.S53L	MLL5_uc010lja.1_5'UTR|MLL5_uc010ljb.1_Missense_Mutation_p.S53L|MLL5_uc003vcl.2_Missense_Mutation_p.S53L|MLL5_uc010ljc.2_Missense_Mutation_p.S53L	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	53					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						TCACATCATTCACACAGTTAC	0.398													59	221					0	0	0	0	T	104702697	T	T	104702697	3	4	4	1	0	0	0	0	1	0	0	0	9677	838	29	2	164	2	MLL5	7	104702697	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2037139	104702697	54435966	149	911											
PIK3CG	5294	broad.mit.edu	37	chr7	106509918	106509918	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggactgcaacttctcagatGaaaatgtaagagccattgca	14	10	9	8	0	1	3	1	1	1	2	2	4	1	4	1	1	4	3	1	1	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:106509918G>C	uc003vdv.3	+	2	1997	c.1912G>C	c.(1912-1914)GAA>CAA	p.E638Q	PIK3CG_uc003vdu.2_Missense_Mutation_p.E638Q|PIK3CG_uc003vdw.2_Missense_Mutation_p.E638Q	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	638					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CTTCTCAGATGAAAATGTAAG	0.348													3	110					0	0	0	0	C	106509918	C	C	106509918	3	2	4	1	0	0	0	0	1	0	0	0	11971	1291	45	2	1914	2	PIK3CG	7	106509918	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1807221	106509918	52628745	150	912											
ASZ1	136991	broad.mit.edu	37	chr7	117060270	117060270	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtagtagttctacacacttCaagatctgttcctctgagcc	10	13	7	11	0	4	2	1	1	3	1	5	2	5	2	2	0	2	4	2	0	4	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:117060270C>T	uc003vjb.2	-	4	450	c.387G>A	c.(385-387)TTG>TTA	p.L129L	ASZ1_uc011kno.1_Silent_p.L129L|ASZ1_uc011knp.1_5'UTR	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	129	ANK 3.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CTACACACTTCAAGATCTGTT	0.338													18	120					0	0	0	0	T	117060270	T	T	117060270	2	4	4	1	0	0	0	0	0	0	0	1	1071	825	29	2		2	ASZ1	7	117060270	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	10550352	117060270	42078393	151	913											
CFTR	1080	broad.mit.edu	37	chr7	117232003	117232003	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaagctgtgtctgtaaactGatggctaacaaaactaggat	15	11	9	6	0	1	1	0	1	1	0	1	2	1	2	0	2	4	3	0	2	8	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:117232003G>A	uc003vjd.2	+	14	1914	c.1782G>A	c.(1780-1782)CTG>CTA	p.L594L	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	594	Cytoplasmic (Potential).|ABC transporter 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TCTGTAAACTGATGGCTAACA	0.259									Cystic_Fibrosis				12	108					0	0	0	0	A	117232003	A	A	117232003	2	1	4	1	0	0	0	0	0	0	0	1	3309	1277	45	2		2	CFTR	7	117232003	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	171733	117232003	41906660	152	914											
UBN2	254048	broad.mit.edu	37	chr7	138969091	138969091	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaaatcttcaggccccctCaaagctaacaaactcatcat	17	8	3	13	0	5	0	4	0	1	0	5	0	5	0	2	1	3	1	2	1	6	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:138969091C>G	uc011kqr.1	+	15	3440	c.3440C>G	c.(3439-3441)TCA>TGA	p.S1147*		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1147	Ser-rich.									ovary(1)|skin(1)	2						CAGGCCCCCTCAAAGCTAACA	0.473													3	93					0	0	0	0	G	138969091	G	G	138969091	4	3	4	1	0	0	0	0	0	1	0	0	16961	838	29	2	3498	2	UBN2	7	138969091	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	21737088	138969091	20169572	153	915											
CUL1	8454	broad.mit.edu	37	chr7	148485666	148485666	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcaagcttgcgggttcgaGtacacctctaaacttcagcg	10	9	10	12	3	2	0	1	0	1	0	3	1	2	0	1	1	6	4	1	1	4	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:148485666G>C	uc010lpg.2	+	14	2023	c.1497G>C	c.(1495-1497)GAG>GAC	p.E499D	CUL1_uc003wey.2_Missense_Mutation_p.E499D|CUL1_uc003wez.2_Missense_Mutation_p.E389D|CUL1_uc003wfa.2_Missense_Mutation_p.E160D	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	499					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GCGGGTTCGAGTACACCTCTA	0.398													60	120					0	0	0	0	C	148485666	C	C	148485666	3	2	4	1	0	0	0	0	1	0	0	0	4071	1020	36	4	1547	4	CUL1	7	148485666	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	9516575	148485666	10652997	154	916											
GALNTL5	168391	broad.mit.edu	37	chr7	151684344	151684344	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggctgattcgagcaaggctGattggagcttctcatgcttc	7	12	13	9	1	1	2	1	2	1	0	4	4	1	3	0	3	3	5	0	3	1	4	rs140077291		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr7:151684344G>C	uc003wkp.2	+	5	859	c.636G>C	c.(634-636)CTG>CTC	p.L212L	GALNTL5_uc003wkq.2_Intron|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Silent_p.L101L	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	212	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		GAGCAAGGCTGATTGGAGCTT	0.468													22	69					0	0	0	0	C	151684344	C	C	151684344	2	2	4	1	0	0	0	0	0	0	0	1	6259	1277	45	2		2	GALNTL5	7	151684344	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	3198678	151684344	7454319	155	917											
NEIL2	252969	broad.mit.edu	37	chr8	11643525	11643525	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgggatccatcccctttctCtcggttcagtcctgagtgcc	4	13	9	15	1	2	1	1	1	1	0	7	2	5	2	5	2	1	1	5	2	0	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:11643525C>G	uc003wug.2	+	5	1417	c.742C>G	c.(742-744)CTC>GTC	p.L248V	NEIL2_uc003wue.2_Missense_Mutation_p.L248V|NEIL2_uc003wuf.2_Missense_Mutation_p.L187V|NEIL2_uc011kxd.1_Missense_Mutation_p.L132V	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	248					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		TCCCCTTTCTCTCGGTTCAGT	0.552								BER_DNA_glycosylases					9	456					0	0	0	0	G	11643525	G	G	11643525	3	3	4	1	0	0	0	0	1	0	0	0	10373	913	32	2	761	2	NEIL2	8	11643525	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08		11643525	134720497	156	918											
C8orf79	57604	broad.mit.edu	37	chr8	12878578	12878578	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataaaagaaatggccagggtCttagttcccggaggccaact	13	8	11	9	1	1	1	0	0	1	1	2	2	2	2	3	4	1	1	3	4	5	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:12878578C>T	uc010lsq.2	+	5	882	c.390C>T	c.(388-390)GTC>GTT	p.V130V	C8orf79_uc011kxw.1_Intron|C8orf79_uc003wwj.3_Silent_p.V43V|C8orf79_uc010lsr.2_Silent_p.V4V	NM_020844	NP_065895	Q9P272	K1456_HUMAN	hypothetical protein LOC57604 isoform 1	130							methyltransferase activity				0						TGGCCAGGGTCTTAGTTCCCG	0.418													3	20					0	0	0	0	T	12878578	T	T	12878578	2	4	4	1	0	0	0	0	0	0	0	1	2450	900	32	2		2	C8orf79	8	12878578	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1235053	12878578	133485444	157	919											
PCM1	5108	broad.mit.edu	37	chr8	17817912	17817912	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agaaactgattgacattcagGagaaaattcaagcattgcaa	18	9	8	6	0	2	4	2	2	0	2	2	5	2	4	0	1	3	2	0	1	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:17817912G>C	uc003wyi.3	+	15	2703	c.2281G>C	c.(2281-2283)GAG>CAG	p.E761Q	PCM1_uc011kyh.1_Missense_Mutation_p.E761Q|PCM1_uc003wyj.3_Missense_Mutation_p.E762Q	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	761	Potential.				centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		TGACATTCAGGAGAAAATTCA	0.333			T	RET|JAK2	papillary thyroid|CML|MPD								27	63					0	0	0	0	C	17817912	C	C	17817912	3	2	4	1	0	0	0	0	1	0	0	0	11638	1175	41	2	2331	2	PCM1	8	17817912	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	4939334	17817912	128546110	158	920											
INTS10	55174	broad.mit.edu	37	chr8	19709251	19709251	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcccgctgtggagagaatCtgatggtggttctgcacagg	7	11	14	9	1	3	2	0	1	3	1	4	4	3	3	1	4	1	3	1	4	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:19709251C>G	uc003wzj.2	+	17	2199	c.2068C>G	c.(2068-2070)CTG>GTG	p.L690V		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	690					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		TGGAGAGAATCTGATGGTGGT	0.557													18	120					0	0	0	0	G	19709251	G	G	19709251	3	3	4	1	0	0	0	0	1	0	0	0	7815	912	32	2	2134	2	INTS10	8	19709251	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1891339	19709251	126654771	159	921											
FGF17	8822	broad.mit.edu	37	chr8	21900473	21900473	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctgctgcccaacctcactCtgtaagtgtgctacctctcc	6	11	7	17	0	3	0	1	0	2	0	4	0	3	0	5	0	5	3	5	0	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:21900473C>G	uc003xag.2	+	1	46	c.34C>G	c.(34-36)CTG>GTG	p.L12V	FGF17_uc003xah.2_Missense_Mutation_p.L12V|FGF17_uc003xai.2_5'Flank	NM_003867	NP_003858	O60258	FGF17_HUMAN	fibroblast growth factor 17 precursor	12					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|nervous system development	extracellular space	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		CAACCTCACTCTGTAAGTGTG	0.657													11	16					0	0	0	0	G	21900473	G	G	21900473	3	3	4	1	0	0	0	0	1	0	0	0	5877	927	32	2	36	2	FGF17	8	21900473	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2191222	21900473	124463549	160	922											
UNC5D	137970	broad.mit.edu	37	chr8	35631911	35631911	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaattccctactccatcaGacagcggatttgtgctacat	12	11	6	12	1	1	1	1	0	0	1	3	2	3	2	2	1	4	1	2	1	4	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:35631911G>T	uc003xjr.1	+	16	2901	c.2573G>T	c.(2572-2574)AGA>ATA	p.R858I	UNC5D_uc003xjs.1_Missense_Mutation_p.R853I|UNC5D_uc003xju.1_Missense_Mutation_p.R434I	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	858	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TACTCCATCAGACAGCGGATT	0.473													32	83					1.30897e-18	1.43724e-18	1	0	T	35631911	T	T	35631911	3	4	4	1	0	0	0	0	1	0	0	0	17063	942	33	2	2635	2	UNC5D	8	35631911	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	13731438	35631911	110732111	161	923											
CPA6	57094	broad.mit.edu	37	chr8	68419035	68419035	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacttacttcttttacaaacCactgacaaaaggcaggacca	16	9	5	11	0	1	1	0	1	1	0	1	2	1	2	2	2	4	1	2	2	6	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:68419035C>T	uc003xxq.3	-	6	879	c.623G>A	c.(622-624)TGG>TAG	p.W208*	CPA6_uc003xxr.3_Nonsense_Mutation_p.W60*|CPA6_uc003xxs.2_Nonsense_Mutation_p.W208*	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	208					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			TTTTACAAACCACTGACAAAA	0.403													51	69					0	0	0	0	T	68419035	T	T	68419035	4	4	4	1	0	0	0	0	0	1	0	0	3809	595	21	4	714	4	CPA6	8	68419035	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	32787124	68419035	77944987	162	924											
PAG1	55824	broad.mit.edu	37	chr8	81905367	81905367	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctagagcacaggaagatgagGaaggtgatgacgaagaaaat	18	5	14	4	1	0	6	0	3	0	3	0	9	0	8	0	3	1	1	0	3	6	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:81905367G>A	uc003ybz.2	-	4	807	c.96C>T	c.(94-96)TTC>TTT	p.F32F		NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid	32	Helical; Signal-anchor for type III membrane protein; (Potential).				epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			GGAAGATGAGGAAGGTGATGA	0.542													3	56					0	0	0	0	A	81905367	A	A	81905367	2	1	4	1	0	0	0	0	0	0	0	1	11442	1165	41	2		2	PAG1	8	81905367	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	13486332	81905367	64458655	163	925											
KIAA1429	25962	broad.mit.edu	37	chr8	95507153	95507153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacatagatttcaactgatCatccatgacatcagcaagca	15	9	5	12	0	3	3	3	2	0	1	4	3	4	3	2	0	3	2	2	0	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:95507153C>T	uc003ygo.1	-	20	4589	c.4576G>A	c.(4576-4578)GAT>AAT	p.D1526N	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1526					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTCAACTGATCATCCATGACA	0.308													32	359					0	0	0	0	T	95507153	T	T	95507153	3	4	4	1	0	0	0	0	1	0	0	0	8270	826	29	2	882	2	KIAA1429	8	95507153	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	13601786	95507153	50856869	164	926											
CSMD3	114788	broad.mit.edu	37	chr8	113358362	113358362	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttattgtccatgtgcaatCtaaactgctgggatagtttc	10	16	8	7	0	1	0	0	0	1	0	3	1	2	1	1	1	3	3	1	1	5	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:113358362C>G	uc003ynu.2	-	41	6565	c.6406G>C	c.(6406-6408)GAT>CAT	p.D2136H	CSMD3_uc003yns.2_Missense_Mutation_p.D1338H|CSMD3_uc003ynt.2_Missense_Mutation_p.D2096H|CSMD3_uc011lhx.1_Missense_Mutation_p.D2032H	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2136	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATGTGCAATCTAAACTGCTG	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	234					0	0	0	0	G	113358362	G	G	113358362	3	3	4	1	0	0	0	0	1	0	0	0	3963	913	32	2	4841	2	CSMD3	8	113358362	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	17851209	113358362	33005660	165	927											
CSMD3	114788	broad.mit.edu	37	chr8	113697953	113697953	+	Frame_Shift_Del	DEL	G	-	-																															tggtgcagtaaagttagacaGgcagggaactggtgaaacag																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:113697953delG	uc003ynu.2	-	15	2323	c.2164delC	c.(2164-2166)CTGfs	p.L722fs	CSMD3_uc003yns.2_5'UTR|CSMD3_uc003ynt.2_Frame_Shift_Del_p.L682fs|CSMD3_uc011lhx.1_Frame_Shift_Del_p.L618fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	722	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAGTTAGACAGGCAGGGAACT	0.318										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---								-	113697953	-	-	113697953	7	5	4	1	0	1	0	1	0	0	0	0	3963	991	35	0	9187	0	CSMD3	8	113697953	Frame_Shift_Del	DEL	G	TCGA-BA-4077-01B-01D-1434-08	339591	113697953	32666069	166	928											
NAPRT1	93100	broad.mit.edu	37	chr8	144659478	144659478	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaggctgtcaggcccccatCggggccctgagcccgcctca	5	5	14	17	2	2	1	2	1	0	0	3	2	2	2	5	5	1	1	5	5	0	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr8:144659478C>T	uc003yym.3	-	4	554	c.529G>A	c.(529-531)GAT>AAT	p.D177N	NAPRT1_uc003yyn.3_Missense_Mutation_p.D177N|NAPRT1_uc011lkh.1_Missense_Mutation_p.D177N|NAPRT1_uc003yyo.3_Missense_Mutation_p.D177N	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	177					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AGGCCCCCATCGGGGCCCTGA	0.692													16	4					0	0	0	0	T	144659478	T	T	144659478	3	4	4	1	0	0	0	0	1	0	0	0	10218	884	31	1	1127	1	NAPRT1	8	144659478	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	30961525	144659478	1704544	167	929											
JAK2	3717	broad.mit.edu	37	chr9	5029862	5029862	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tatccacccaaccatgtcttCcatatagatgagtcaaccag	13	10	5	13	0	2	2	1	1	1	1	4	2	4	2	5	0	2	0	5	0	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:5029862C>T	uc010mhm.2	+	3	419	c.306C>T	c.(304-306)TTC>TTT	p.F102F	JAK2_uc003ziw.2_Silent_p.F102F	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	102	Interaction with cytokine/interferon/growth hormone receptors (By similarity).|FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		ACCATGTCTTCCATATAGATG	0.363		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				24	252					0	0	0	0	T	5029862	T	T	5029862	2	4	4	1	0	0	0	0	0	0	0	1	7977	854	30	2		2	JAK2	9	5029862	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08		5029862	136183569	168	930											
C9orf131	138724	broad.mit.edu	37	chr9	35044713	35044713	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcactctctactcctctacCagagccacacattgaccttg	9	11	4	17	0	3	2	1	1	2	1	5	2	4	2	4	0	3	0	4	0	2	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:35044713C>T	uc003zvw.2	+	2	2116	c.2087C>T	c.(2086-2088)CCA>CTA	p.P696L	C9orf131_uc003zvu.2_Missense_Mutation_p.P648L|C9orf131_uc003zvv.2_Missense_Mutation_p.P623L|C9orf131_uc003zvx.2_Missense_Mutation_p.P661L	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	696											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			ACTCCTCTACCAGAGCCACAC	0.552													14	84					0	0	0	0	T	35044713	T	T	35044713	3	4	4	1	0	0	0	0	1	0	0	0	2469	594	21	4	2109	4	C9orf131	9	35044713	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	30014851	35044713	106168718	169	931											
TLN1	7094	broad.mit.edu	37	chr9	35720452	35720452	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttgggggacactgagtcctCcagcatagtagactcctcat	9	11	10	11	0	1	2	1	1	0	1	4	3	4	3	3	2	1	2	3	2	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:35720452C>G	uc003zxt.2	-	12	1615	c.1261G>C	c.(1261-1263)GAG>CAG	p.E421Q		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	421	Interaction with LAYN (By similarity).				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ACTGAGTCCTCCAGCATAGTA	0.488													44	461					0	0	0	0	G	35720452	G	G	35720452	3	3	4	1	0	0	0	0	1	0	0	0	16013	864	30	2	6548	2	TLN1	9	35720452	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	675739	35720452	105492979	170	932											
POLR1E	64425	broad.mit.edu	37	chr9	37503070	37503070	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagccaaagccatgaggctGaagatctccaaaagaagggt	16	6	11	8	0	1	4	0	2	1	2	2	4	1	4	3	2	2	1	3	2	6	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:37503070G>A	uc003zzz.1	+	11	1605	c.1317G>A	c.(1315-1317)CTG>CTA	p.L439L	POLR1E_uc003zzy.1_Silent_p.L377L|POLR1E_uc011lqk.1_Silent_p.L306L|uc004aaa.2_5'Flank	NM_022490	NP_071935	Q9GZS1	RPA49_HUMAN	RNA polymerase I associated factor 53	439					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		CCATGAGGCTGAAGATCTCCA	0.542													41	201					0	0	0	0	A	37503070	A	A	37503070	2	1	4	1	0	0	0	0	0	0	0	1	12268	1277	45	2		2	POLR1E	9	37503070	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1782618	37503070	103710361	171	933											
PRUNE2	158471	broad.mit.edu	37	chr9	79320938	79320939	+	Frame_Shift_Ins	INS	-	CCAT	CCAT																															tcaggatatcaggattctcaINSccatctgctttcaaactgaa																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:79320938_79320939insCCAT	uc010mpk.2	-	8	6375_6376	c.6251_6252insATGG	c.(6250-6252)GGTfs	p.G2084fs	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2084					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CAGGATTCTCACCATCTGCTTT	0.49													---	---	---								CCAT	79320939	CCAT	CCAT	79320938	7	5	4	1	0	1	1	0	0	0	0	0	12703	146	6	0	3062	0	PRUNE2	9	79320938	Frame_Shift_Ins	INS	-	TCGA-BA-4077-01B-01D-1434-08	41817868	79320938	61892493	172	934											
FLJ46321	389763	broad.mit.edu	37	chr9	84606906	84606906	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtccagctcttctggggtctCccatctttgcacagcgagtc	5	12	10	14	1	4	0	0	0	4	0	7	1	5	0	2	2	3	2	2	2	0	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:84606906C>G	uc004amn.2	+	4	1568	c.1521C>G	c.(1519-1521)CTC>CTG	p.L507L		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	507						integral to membrane					0						TCTGGGGTCTCCCATCTTTGC	0.438													30	83					0	0	0	0	G	84606906	G	G	84606906	2	3	4	1	0	0	0	0	0	0	0	1	5964	842	30	2		2	FLJ46321	9	84606906	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	5285968	84606906	56606525	173	935											
S1PR3	1903	broad.mit.edu	37	chr9	91617111	91617111	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcacccatccagcctgcgctCgacccaagcagaagtaaatc	12	6	7	16	2	1	1	1	0	0	1	4	2	2	1	4	0	3	3	4	0	4	1	rs138808274		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:91617111C>T	uc004aqe.2	+	2	1392	c.996C>T	c.(994-996)CTC>CTT	p.L332L		NM_005226	NP_005217	Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	332	Cytoplasmic (By similarity).				anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)|central_nervous_system(1)|skin(1)	5						AGCCTGCGCTCGACCCAAGCA	0.632													6	79					0	0	0	0	T	91617111	T	T	91617111	2	4	4	1	0	0	0	0	0	0	0	1	13860	871	31	1		1	S1PR3	9	91617111	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	7010205	91617111	49596320	174	936											
HABP4	22927	broad.mit.edu	37	chr9	99227683	99227683	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggcccgagagggggtatgCgcggcagaggcagaggtggc	8	3	22	8	3	0	3	0	0	0	3	0	5	0	3	1	7	1	3	1	7	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:99227683C>T	uc010msg.2	+	3	725	c.577C>T	c.(577-579)CGC>TGC	p.R193C	HABP4_uc010msh.2_Intron	NM_014282	NP_055097	Q5JVS0	HABP4_HUMAN	hyaluronan binding protein 4	193					platelet activation|platelet degranulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|extracellular region|nucleus	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0169)|all_hematologic(171;0.214)				AGGGGGTATGCGCGGCAGAGG	0.483													6	290					0	0	0	0	T	99227683	T	T	99227683	3	4	4	1	0	0	0	0	1	0	0	0	6978	768	27	1	587	1	HABP4	9	99227683	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	7610572	99227683	41985748	175	937											
TRIM14	9830	broad.mit.edu	37	chr9	100862396	100862396	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttcgtcaagtagtaatctGagttcagtgaatttcccctt	9	16	7	9	1	4	2	2	2	2	0	6	2	5	2	2	0	0	3	2	0	4	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:100862396G>C	uc004ayd.2	-	3	372	c.354C>G	c.(352-354)CTC>CTG	p.L118L	TRIM14_uc004ayf.1_Silent_p.L25L|TRIM14_uc004ayg.1_Silent_p.L118L|TRIM14_uc004ayh.1_Silent_p.L118L|TRIM14_uc004ayi.1_Silent_p.L118L|TRIM14_uc004ayj.1_Silent_p.L25L	NM_033220	NP_150089	Q14142	TRI14_HUMAN	tripartite motif protein TRIM14 isoform alpha	118						cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GTAGTAATCTGAGTTCAGTGA	0.373													48	238					0	0	0	0	C	100862396	C	C	100862396	2	2	4	1	0	0	0	0	0	0	0	1	16556	1277	45	2		2	TRIM14	9	100862396	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1634713	100862396	40351035	176	938											
ANKS6	203286	broad.mit.edu	37	chr9	101540657	101540657	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcccacggggcagcgtcTgcatcagtttgagctttcgg	7	9	13	12	3	2	1	1	1	1	0	3	1	2	1	1	3	4	4	1	3	0	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:101540657T>C	uc004ayu.2	-	7	1439	c.1418A>G	c.(1417-1419)CAG>CGG	p.Q473R	ANKS6_uc004ayt.2_Missense_Mutation_p.Q172R|ANKS6_uc004ayv.1_5'Flank|ANKS6_uc004ayw.1_Missense_Mutation_p.Q55R|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	473										ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				GGGCAGCGTCTGCATCAGTTT	0.587													31	38					0	0	0	0	C	101540657	C	C	101540657	3	2	4	1	0	0	0	0	1	0	0	0	692	1580	55	5	1233	5	ANKS6	9	101540657	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	678261	101540657	39672774	177	939											
SVEP1	79987	broad.mit.edu	37	chr9	113243615	113243615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtagacccttctgtgaaatCatagccctccaagcaagtta	13	10	7	11	0	2	2	1	1	1	1	3	2	3	2	3	0	2	3	3	0	6	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:113243615C>T	uc010mtz.2	-	12	2609	c.2272G>A	c.(2272-2274)GAT>AAT	p.D758N	SVEP1_uc010mua.1_Missense_Mutation_p.D758N|SVEP1_uc004beu.2_Missense_Mutation_p.D758N	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	758	Sushi 4.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TCTGTGAAATCATAGCCCTCC	0.413													6	45					0	0	0	0	T	113243615	T	T	113243615	3	4	4	1	0	0	0	0	1	0	0	0	15486	826	29	2	8591	2	SVEP1	9	113243615	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	11702958	113243615	27969816	178	940											
UGCG	7357	broad.mit.edu	37	chr9	114695273	114695273	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcagaggaaatcctagatgTataactacagctttgtgact	14	11	9	7	0	0	3	0	1	0	2	1	4	1	4	1	1	4	3	1	1	5	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:114695273T>A	uc004bft.2	+	9	1471	c.1181T>A	c.(1180-1182)GTA>GAA	p.V394E		NM_003358	NP_003349	Q16739	CEGT_HUMAN	ceramide glucosyltransferase	394	Cytoplasmic (Potential).				epidermis development|glucosylceramide biosynthetic process	Golgi membrane|integral to membrane|membrane fraction	ceramide glucosyltransferase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.0433)	Miglustat(DB00419)	ATCCTAGATGTATAACTACAG	0.333													33	94					0	0	0	0	A	114695273	A	A	114695273	3	1	4	1	0	0	0	0	1	0	0	0	17007	1638	57	5	1215	5	UGCG	9	114695273	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	1451658	114695273	26518158	179	941											
TLR4	7099	broad.mit.edu	37	chr9	120476116	120476116	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacagcattttccaagtagTctagctttcttaaatcttac	11	16	4	10	0	3	0	0	0	3	0	4	0	4	0	1	0	4	3	1	0	7	8			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:120476116T>C	uc004bjz.2	+	3	2001	c.1710T>C	c.(1708-1710)AGT>AGC	p.S570S	TLR4_uc004bka.2_Silent_p.S530S|TLR4_uc004bkb.2_Silent_p.S370S	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	570	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTCCAAGTAGTCTAGCTTTCT	0.413													73	60					0	0	0	0	C	120476116	C	C	120476116	2	2	4	1	0	0	0	0	0	0	0	1	16019	1664	58	5		5	TLR4	9	120476116	Silent	SNP	T	TCGA-BA-4077-01B-01D-1434-08	5780843	120476116	20737315	180	942											
LHX6	26468	broad.mit.edu	37	chr9	124979413	124979413	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatgcggcagagcaccttctCctcgaccaggccgaactcct	8	7	10	16	3	1	1	0	0	1	1	4	4	2	1	5	2	3	2	5	2	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:124979413C>G	uc010mvw.2	-	4	638	c.529G>C	c.(529-531)GAG>CAG	p.E177Q	LHX6_uc004blx.3_Missense_Mutation_p.E206Q|LHX6_uc004bly.3_Missense_Mutation_p.E206Q	NM_014368	NP_055183	Q9UPM6	LHX6_HUMAN	LIM homeobox protein 6 isoform 1	177	LIM zinc-binding 2.|Required for interaction with LBD1 (By similarity).				cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCACCTTCTCCTCGACCAGG	0.647													19	108					0	0	0	0	G	124979413	G	G	124979413	3	3	4	1	0	0	0	0	1	0	0	0	8816	864	30	2	645	2	LHX6	9	124979413	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	4503297	124979413	16234018	181	943											
RABGAP1	23637	broad.mit.edu	37	chr9	125772653	125772653	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataaagcaaagggagagaaaGaataatactgacactttata	21	8	8	4	0	0	3	0	1	0	2	0	5	0	4	0	1	2	1	0	1	9	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:125772653G>C	uc011lzh.1	+	11	1529	c.1395G>C	c.(1393-1395)AAG>AAC	p.K465N	RABGAP1_uc004bnl.3_RNA	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	465					cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						GGGAGAGAAAGAATAATACTG	0.318													33	128					0	0	0	0	C	125772653	C	C	125772653	3	2	4	1	0	0	0	0	1	0	0	0	13029	933	33	2	1433	2	RABGAP1	9	125772653	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	793240	125772653	15440778	182	944											
ANGPTL2	23452	broad.mit.edu	37	chr9	129856193	129856193	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccagggcctgcaggcagTctctccatgggcctggggac	5	7	14	15	0	1	0	0	0	1	0	4	1	3	1	5	5	1	2	5	5	0	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:129856193T>A	uc004bqr.1	-	3	1330	c.830A>T	c.(829-831)GAC>GTC	p.D277V	RALGPS1_uc004bqo.1_Intron|RALGPS1_uc011mab.1_Intron|RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron|ANGPTL2_uc010mxg.1_5'UTR	NM_012098	NP_036230	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2 precursor	277	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding				0						CTGCAGGCAGTCTCTCCATGG	0.617													38	103					0	0	0	0	A	129856193	A	A	129856193	3	1	4	1	0	0	0	0	1	0	0	0	614	1667	58	5	663	5	ANGPTL2	9	129856193	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	4083540	129856193	11357238	183	945											
LRSAM1	90678	broad.mit.edu	37	chr9	130253536	130253536	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tattgcagctgacacagctgGagttaaagaggaagtccctg	12	9	12	8	0	0	2	0	1	0	1	1	4	1	4	1	2	3	4	1	2	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:130253536G>C	uc004brb.1	+	20	1810	c.1465G>C	c.(1465-1467)GAG>CAG	p.E489Q	LRSAM1_uc010mxk.1_Intron|LRSAM1_uc004brc.1_Missense_Mutation_p.E489Q|LRSAM1_uc004brd.1_Missense_Mutation_p.E489Q|LRSAM1_uc004bre.1_Missense_Mutation_p.E69Q	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	489					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						GACACAGCTGGAGTTAAAGAG	0.483													11	95					0	0	0	0	C	130253536	C	C	130253536	3	2	4	1	0	0	0	0	1	0	0	0	9093	1175	41	2	1535	2	LRSAM1	9	130253536	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	397343	130253536	10959895	184	946											
ZER1	10444	broad.mit.edu	37	chr9	131515013	131515013	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctctaggatcatgtggcCagagatgtccagggacatta	10	11	12	8	0	2	1	1	0	1	1	4	4	3	3	2	3	0	1	2	3	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr9:131515013C>T	uc004bwa.1	-	5	1295	c.862G>A	c.(862-864)GGC>AGC	p.G288S		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	288	LRR 3.				ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						ATCATGTGGCCAGAGATGTCC	0.572													3	78					0	0	0	0	T	131515013	T	T	131515013	3	4	4	1	0	0	0	0	1	0	0	0	17692	594	21	4	1486	4	ZER1	9	131515013	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1261477	131515013	9698418	185	947											
TUBAL3	79861	broad.mit.edu	37	chr10	5435546	5435546	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatcttccctggcctccaaGaactctgcttcttccatgcc	7	12	6	16	0	3	2	0	0	3	2	6	2	6	2	5	1	3	1	5	1	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:5435546G>C	uc001ihy.2	-	4	1315	c.1275C>G	c.(1273-1275)TTC>TTG	p.F425L	TUBAL3_uc001ihz.2_Missense_Mutation_p.F385L	NM_024803	NP_079079	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	425					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1						TGGCCTCCAAGAACTCTGCTT	0.532													12	92					0	0	0	0	C	5435546	C	C	5435546	3	2	4	1	0	0	0	0	1	0	0	0	16819	933	33	2	69	2	TUBAL3	10	5435546	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08		5435546	130099201	186	948											
TUBAL3	79861	broad.mit.edu	37	chr10	5437411	5437411	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgctcggggtggaagagtGaacggtgctggcccgtccgg	5	7	19	10	4	0	2	0	1	0	1	2	3	1	3	2	6	3	3	2	6	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:5437411G>A	uc001ihy.2	-	3	315	c.275C>T	c.(274-276)TCA>TTA	p.S92L	TUBAL3_uc001ihz.2_Missense_Mutation_p.S52L	NM_024803	NP_079079	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	92					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1						GTGGAAGAGTGAACGGTGCTG	0.592													32	225					0	0	0	0	A	5437411	A	A	5437411	3	1	4	1	0	0	0	0	1	0	0	0	16819	1294	45	2	1073	2	TUBAL3	10	5437411	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1865	5437411	130097336	187	949											
STAM	8027	broad.mit.edu	37	chr10	17730107	17730107	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaatgatccacagcttagtCtaatatcagcaatgattaag	16	11	7	7	0	2	3	1	2	1	1	3	3	3	3	1	0	2	2	1	0	6	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:17730107C>G	uc001ipj.1	+	5	595	c.379C>G	c.(379-381)CTA>GTA	p.L127V	STAM_uc010qcf.1_Missense_Mutation_p.L16V	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	127	VHS.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2						ACAGCTTAGTCTAATATCAGC	0.363													11	256					0	0	0	0	G	17730107	G	G	17730107	3	3	4	1	0	0	0	0	1	0	0	0	15314	912	32	2	397	2	STAM	10	17730107	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	12292696	17730107	117804640	188	950											
PTCHD3	374308	broad.mit.edu	37	chr10	27700799	27700799	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaggtgaaacacagggatCacagtcacagaagttgcctc	13	6	11	11	0	2	2	2	1	0	1	3	3	2	3	2	2	2	1	2	2	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:27700799C>T	uc001itu.2	-	2	1267	c.1149G>A	c.(1147-1149)GTG>GTA	p.V383V		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	383	SSD.|Helical; (Potential).				spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						ACACAGGGATCACAGTCACAG	0.358													10	58					0	0	0	0	T	27700799	T	T	27700799	2	4	4	1	0	0	0	0	0	0	0	1	12796	813	29	2		2	PTCHD3	10	27700799	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	9970692	27700799	107833948	189	951											
KIAA1279	26128	broad.mit.edu	37	chr10	70748834	70748834	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccggctgaggtggtggaGcccgaggggcccgtcgccca	4	5	18	14	4	0	1	0	1	0	0	1	3	0	2	4	6	2	1	4	6	0	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:70748834G>C	uc001joy.2	+	1	342	c.246G>C	c.(244-246)GAG>GAC	p.E82D		NM_015634	NP_056449	Q96EK5	KBP_HUMAN	KIF1 binding protein	82					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			ovary(1)	1						AGGTGGTGGAGCCCGAGGGGC	0.731													3	46					0	0	0	0	C	70748834	C	C	70748834	3	2	4	1	0	0	0	0	1	0	0	0	8260	962	34	4	248	4	KIAA1279	10	70748834	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	43048035	70748834	64785913	190	952											
KIAA1279	26128	broad.mit.edu	37	chr10	70775627	70775627	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cattctttgaaactgacatgGagagacggtgcaagatgcat	13	10	11	7	1	1	4	0	2	1	2	1	6	1	5	0	2	3	2	0	2	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:70775627G>T	uc001joy.2	+	7	1417	c.1321G>T	c.(1321-1323)GAG>TAG	p.E441*		NM_015634	NP_056449	Q96EK5	KBP_HUMAN	KIF1 binding protein	441					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			ovary(1)	1						AACTGACATGGAGAGACGGTG	0.433													64	127					6.56249e-45	7.35336e-45	1	0	T	70775627	T	T	70775627	4	4	4	1	0	0	0	0	0	1	0	0	8260	1175	41	2	1347	2	KIAA1279	10	70775627	Nonsense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	26793	70775627	64759120	191	953											
SEC24C	9632	broad.mit.edu	37	chr10	75529650	75529650	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgaactgtgtgttgaaGagtgatgtcctgcagcctgg	8	12	13	8	0	0	4	0	3	0	1	1	4	1	4	3	1	4	2	3	1	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:75529650G>T	uc001juw.2	+	21	2918	c.2739G>T	c.(2737-2739)AAG>AAT	p.K913N	SEC24C_uc001jux.2_Missense_Mutation_p.K913N|SEC24C_uc010qko.1_Missense_Mutation_p.K794N|SEC24C_uc010qkp.1_Missense_Mutation_p.K161N|SEC24C_uc010qkq.1_Missense_Mutation_p.K161N|FUT11_uc001juy.1_5'Flank|FUT11_uc001juz.1_5'Flank|FUT11_uc001jva.2_5'Flank	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	913					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					GTGTGTTGAAGAGTGATGTCC	0.463													46	266					1.56793e-16	1.70444e-16	1	0	T	75529650	T	T	75529650	3	4	4	1	0	0	0	0	1	0	0	0	14061	933	33	2	2813	2	SEC24C	10	75529650	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	4754023	75529650	60005097	192	954											
POLR3A	11128	broad.mit.edu	37	chr10	79753020	79753020	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccctccatagctgcaggatCtaagccatctcctccataaa	11	10	5	15	0	2	0	0	0	2	0	6	1	5	1	5	1	3	2	5	1	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:79753020C>G	uc001jzn.2	-	20	2816	c.2722G>C	c.(2722-2724)GAT>CAT	p.D908H		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	908					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GCTGCAGGATCTAAGCCATCT	0.413													19	228					0	0	0	0	G	79753020	G	G	79753020	3	3	4	1	0	0	0	0	1	0	0	0	12283	913	32	2	1498	2	POLR3A	10	79753020	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	4223370	79753020	55781727	193	955											
LRIT2	340745	broad.mit.edu	37	chr10	85982250	85982250	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caatgtaggcattgccctccGaggggatggaaagagaatca	13	7	13	8	1	1	1	1	0	0	1	2	5	2	3	2	4	1	2	2	4	4	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:85982250G>C	uc001kcy.2	-	3	1087	c.1079C>G	c.(1078-1080)TCG>TGG	p.S360W	LRIT2_uc010qmc.1_Missense_Mutation_p.S370W	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	360						integral to membrane				ovary(2)	2						ATTGCCCTCCGAGGGGATGGA	0.552													3	61					0	0	0	0	C	85982250	C	C	85982250	3	2	4	1	0	0	0	0	1	0	0	0	8998	1059	37	3	577	3	LRIT2	10	85982250	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	6229230	85982250	49552497	194	956											
WAPAL	23063	broad.mit.edu	37	chr10	88260338	88260338	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggagatatttctgatggtGattctggccttttcccaaac	8	16	9	8	0	2	3	0	2	2	1	3	4	3	3	2	3	1	0	2	3	2	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:88260338G>A	uc001kdo.2	-	3	1104	c.662C>T	c.(661-663)TCA>TTA	p.S221L	WAPAL_uc001kdn.2_Missense_Mutation_p.S264L|WAPAL_uc009xsw.2_Missense_Mutation_p.S221L	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	221	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						TTCTGATGGTGATTCTGGCCT	0.373													39	335					0	0	0	0	A	88260338	A	A	88260338	3	1	4	1	0	0	0	0	1	0	0	0	17316	1294	45	2	2978	2	WAPAL	10	88260338	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2278088	88260338	47274409	195	957											
RPP30	10556	broad.mit.edu	37	chr10	92655643	92655643	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcattttatttcagcctttaGaaataagagggccatatgac	13	14	7	7	0	2	3	2	1	0	2	2	3	2	3	2	1	1	0	2	1	5	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:92655643G>C	uc009xtx.2	+	9	621	c.586G>C	c.(586-588)GAA>CAA	p.E196Q	RPP30_uc001khd.2_Missense_Mutation_p.E196Q	NM_006413	NP_006404	P78346	RPP30_HUMAN	ribonuclease P/MRP 30kDa subunit isoform b	196					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0						TCAGCCTTTAGAAATAAGAGG	0.274													15	127					0	0	0	0	C	92655643	C	C	92655643	3	2	4	1	0	0	0	0	1	0	0	0	13677	943	33	2	620	2	RPP30	10	92655643	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	4395305	92655643	42879104	196	958											
LOC729020	729020	broad.mit.edu	37	chr10	105006203	105006203	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaccggggtttggagagcaGaaattcatggaagatatgat	14	9	14	4	1	1	4	1	1	0	3	1	7	1	5	1	4	2	2	1	4	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr10:105006203G>A	uc009xxi.2	+	1	560	c.450G>A	c.(448-450)CAG>CAA	p.Q150Q	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	150					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						TTGGAGAGCAGAAATTCATGG	0.473													15	123					0	0	0	0	A	105006203	A	A	105006203	2	1	4	1	0	0	0	0	0	0	0	1	8938	933	33	2		2	LOC729020	10	105006203	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	12350560	105006203	30528544	197	959											
PHRF1	57661	broad.mit.edu	37	chr11	607897	607897	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagaggaaggagaacccctCacccctcttctccatcaaga	12	6	8	15	0	4	3	2	0	2	3	5	5	4	4	5	2	1	1	5	2	3	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:607897C>T	uc001lqe.2	+	14	2572	c.2441C>T	c.(2440-2442)TCA>TTA	p.S814L	PHRF1_uc010qwc.1_Missense_Mutation_p.S813L|PHRF1_uc010qwd.1_Missense_Mutation_p.S812L|PHRF1_uc010qwe.1_Missense_Mutation_p.S810L|PHRF1_uc009ybz.1_Missense_Mutation_p.S604L|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	814							RNA polymerase binding|zinc ion binding				0						GAGAACCCCTCACCCCTCTTC	0.617													8	145					0	0	0	0	T	607897	T	T	607897	3	4	4	1	0	0	0	0	1	0	0	0	11916	838	29	2	2488	2	PHRF1	11	607897	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08		607897	134398619	198	960											
DEAF1	10522	broad.mit.edu	37	chr11	687928	687928	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacctgagccgagcctgttcTtgtacagagtgccgctgatg	7	10	12	12	2	1	3	0	2	1	1	1	4	1	3	4	0	4	3	4	0	1	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:687928T>A	uc001lqq.1	-	4	1340	c.647A>T	c.(646-648)AAG>ATG	p.K216M	DEAF1_uc009ycf.1_RNA	NM_021008	NP_066288	O75398	DEAF1_HUMAN	deformed epidermal autoregulatory factor 1	216	SAND.				embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding				0		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GAGCCTGTTCTTGTACAGAGT	0.522													17	84					0	0	0	0	A	687928	A	A	687928	3	1	4	1	0	0	0	0	1	0	0	0	4397	1609	56	5	1086	5	DEAF1	11	687928	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	80031	687928	134318588	199	961											
TRPM5	29850	broad.mit.edu	37	chr11	2434782	2434782	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgcaggatgggcgtgcctgCggccatgtccccccaccaga	6	5	13	17	3	0	1	0	0	0	1	1	2	1	2	7	3	2	1	7	3	0	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:2434782C>T	uc001lwm.3	-	13	1936	c.1927G>A	c.(1927-1929)GCA>ACA	p.A643T	TRPM5_uc010qxl.1_Missense_Mutation_p.A643T|TRPM5_uc009ydn.2_Missense_Mutation_p.A645T	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	643	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGCGTGCCTGCGGCCATGTCC	0.647													6	31					0	0	0	0	T	2434782	T	T	2434782	3	4	4	1	0	0	0	0	1	0	0	0	16656	768	27	1	1618	1	TRPM5	11	2434782	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1746854	2434782	132571734	200	962											
OR51T1	401665	broad.mit.edu	37	chr11	4904108	4904108	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggggtcttaggggaagatggGattgaaggtaggaaattgtc	11	10	18	2	0	1	2	0	1	1	1	2	5	1	5	0	7	0	1	0	7	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:4904108G>A	uc010qyp.1	+	1	1060	c.1060G>A	c.(1060-1062)GAT>AAT	p.D354N		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	327	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGGAAGATGGGATTGAAGGTA	0.468													13	84					0	0	0	0	A	4904108	A	A	4904108	3	1	4	1	0	0	0	0	1	0	0	0	11160	1174	41	2	1062	2	OR51T1	11	4904108	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2469326	4904108	130102408	201	963											
OR51L1	119682	broad.mit.edu	37	chr11	5020494	5020494	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggttggatgctccagagatCcaggcaagtgcttgctatgc	8	11	13	9	0	0	1	0	0	0	1	2	3	2	2	2	3	4	5	2	3	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:5020494C>T	uc010qyu.1	+	1	282	c.282C>T	c.(280-282)ATC>ATT	p.I94I		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCCAGAGATCCAGGCAAGTG	0.478													98	192					0	0	0	0	T	5020494	T	T	5020494	2	4	4	1	0	0	0	0	0	0	0	1	11156	845	30	2		2	OR51L1	11	5020494	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	116386	5020494	129986022	202	964											
NRIP3	56675	broad.mit.edu	37	chr11	9009738	9009744	+	Frame_Shift_Del	DEL	TTCGTCT	-	-																															acttagcctgattgagtttgTtcgtcttagaggcccaaggg																								rs150007282		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:9009738_9009744delTTCGTCT	uc001mhg.2	-	2	374_380	c.260_266delAGACGAA	c.(259-267)AAGACGAACfs	p.K87fs	NRIP3_uc010rbu.1_Frame_Shift_Del_p.K87fs	NM_020645	NP_065696	Q9NQ35	NRIP3_HUMAN	nuclear receptor interacting protein 3	87_89					proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)		ATTGAGTTTGTTCGTCTTAGAGGCCCA	0.483													---	---	---								-	9009744	-	-	9009738	7	5	4	1	0	1	0	1	0	0	0	0	10708	1725	60	0	483	0	NRIP3	11	9009738	Frame_Shift_Del	DEL	TTCGTCT	TCGA-BA-4077-01B-01D-1434-08	3989244	9009738	125996778	203	965											
SWAP70	23075	broad.mit.edu	37	chr11	9735026	9735026	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttttaggtccaagacaactTtgacaagattgaattcaata	15	14	6	6	0	1	4	1	2	0	2	2	4	2	4	1	1	1	0	1	1	7	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:9735026T>C	uc001mhw.2	+	3	353	c.254T>C	c.(253-255)TTT>TCT	p.F85S	SWAP70_uc001mhv.2_Missense_Mutation_p.F85S|SWAP70_uc001mhx.2_Intron	NM_015055	NP_055870	Q9UH65	SWP70_HUMAN	SWAP-70 protein	85						cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			ovary(2)|central_nervous_system(1)	3				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		CAAGACAACTTTGACAAGATT	0.358													47	86					0	0	0	0	C	9735026	C	C	9735026	3	2	4	1	0	0	0	0	1	0	0	0	15491	1841	64	5	264	5	SWAP70	11	9735026	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	725288	9735026	125271490	204	966											
MRGPRX2	117194	broad.mit.edu	37	chr11	19077743	19077743	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtcggccccggccaggctGaggacgtagacagagaaggc	11	3	16	11	3	0	3	0	1	0	2	1	5	0	4	3	5	0	2	3	5	3	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:19077743G>T	uc001mph.2	-	2	295	c.207C>A	c.(205-207)CTC>CTA	p.L69L		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	69	Helical; Name=2; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						CGGCCAGGCTGAGGACGTAGA	0.537													13	123					6.31663e-08	6.60375e-08	1	0	T	19077743	T	T	19077743	2	4	4	1	0	0	0	0	0	0	0	1	9820	1277	45	2		2	MRGPRX2	11	19077743	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	9342717	19077743	115928773	205	967											
CCDC73	493860	broad.mit.edu	37	chr11	32675537	32675537	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttacctgtttttcttctTgaatatgggtaatctcttca	7	20	6	8	0	4	1	1	1	3	0	5	1	4	1	1	1	2	3	1	1	4	8			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:32675537T>G	uc001mtv.2	-	11	865	c.821A>C	c.(820-822)CAA>CCA	p.Q274P	CCDC73_uc001mtw.1_Missense_Mutation_p.Q274P	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	274	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TTTTTCTTCTTGAATATGGGT	0.219													12	25					0	0	0	0	G	32675537	G	G	32675537	3	3	4	1	0	0	0	0	1	0	0	0	2859	1812	63	5	2450	5	CCDC73	11	32675537	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	13597794	32675537	102330979	206	968											
TTC17	55761	broad.mit.edu	37	chr11	43419614	43419614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagctataaagaggaagcatGctgtcctatgtcagcaaaaa	17	8	9	7	0	1	1	1	0	0	1	2	2	2	2	1	1	4	4	1	1	8	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:43419614G>A	uc001mxi.2	+	8	1023	c.1009G>A	c.(1009-1011)GCT>ACT	p.A337T	TTC17_uc001mxh.2_Missense_Mutation_p.A337T|TTC17_uc010rfj.1_Missense_Mutation_p.A280T|TTC17_uc001mxj.2_Missense_Mutation_p.A107T	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	337							binding			ovary(5)	5						GAGGAAGCATGCTGTCCTATG	0.453													31	74					0	0	0	0	A	43419614	A	A	43419614	3	1	4	1	0	0	0	0	1	0	0	0	16752	1319	46	4	1039	4	TTC17	11	43419614	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	10744077	43419614	91586902	207	969											
LPXN	9404	broad.mit.edu	37	chr11	58343414	58343414	+	5'Flank	DEL	T	-	-																															tctcttttgatttggtgagcTtttttttttttttcataggt																								rs34461980		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:58343414delT	uc001nmw.2	-						LPXN_uc009ymp.2_5'Flank|LPXN_uc010rkj.1_Intron|LPXN_uc010rkk.1_Intron	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2						cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				TTTGGTGAGCTTTTTTTTTTT	0.388													---	---	---								-	58343414	-	-	58343414	6	5	4	0	1	1	0	1	0	0	0	0	8979	1624	56	0		0	LPXN	11	58343414	5'Flank	DEL	T	TCGA-BA-4077-01B-01D-1434-08	14923800	58343414	76663102	208	970											
AHNAK	79026	broad.mit.edu	37	chr11	62286923	62286923	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgaaggtgacttgatgtcaGctttggggctttttgcccca	6	14	13	8	0	1	3	1	3	0	0	1	3	1	3	2	3	2	2	2	3	1	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:62286923G>C	uc001ntl.2	-	5	15266	c.14966C>G	c.(14965-14967)GCT>GGT	p.A4989G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4989					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTTGATGTCAGCTTTGGGGCT	0.453													12	203					0	0	0	0	C	62286923	C	C	62286923	3	2	4	1	0	0	0	0	1	0	0	0	414	971	34	4	2826	4	AHNAK	11	62286923	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	3943509	62286923	72719593	209	971											
SLC3A2	6520	broad.mit.edu	37	chr11	62656097	62656097	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccgtgaggagggctcccctCttgagctggaacgcctgaaa	8	7	14	12	2	1	3	0	3	1	0	2	5	2	5	4	3	2	2	4	3	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:62656097C>G	uc001nwd.2	+	12	2049	c.1825C>G	c.(1825-1827)CTT>GTT	p.L609V	SLC3A2_uc001nwb.2_Missense_Mutation_p.L640V|SLC3A2_uc001nwc.2_Missense_Mutation_p.L610V|SLC3A2_uc001nwe.2_Missense_Mutation_p.L578V|SLC3A2_uc001nwf.2_Missense_Mutation_p.L547V|SLC3A2_uc001nwg.2_Missense_Mutation_p.L508V	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	609	Extracellular (Potential).			L -> P (in Ref. 4; AAA35536).	blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						GGGCTCCCCTCTTGAGCTGGA	0.667													63	119					0	0	0	0	G	62656097	G	G	62656097	3	3	4	1	0	0	0	0	1	0	0	0	14691	913	32	2	1971	2	SLC3A2	11	62656097	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	369174	62656097	72350419	210	972											
PPFIA1	8500	broad.mit.edu	37	chr11	70170534	70170534	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagcacttactaaagaactCaatgtatgcagggaacagct	15	8	9	9	0	1	1	1	0	0	1	1	2	1	2	0	1	6	5	0	1	7	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:70170534C>T	uc001opo.2	+	3	489	c.291C>T	c.(289-291)CTC>CTT	p.L97L	PPFIA1_uc001opn.1_Silent_p.L97L|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_5'Flank	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	97	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CTAAAGAACTCAATGTATGCA	0.403													20	341					0	0	0	0	T	70170534	T	T	70170534	2	4	4	1	0	0	0	0	0	0	0	1	12364	813	29	2		2	PPFIA1	11	70170534	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	7514437	70170534	64835982	211	973											
EED	8726	broad.mit.edu	37	chr11	85979511	85979511	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttcaggccatttatttctCagaaaatccattttcctgat	10	16	4	11	0	2	2	2	1	1	1	5	2	4	2	4	1	0	0	4	1	3	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:85979511C>T	uc001pbp.2	+	9	1331	c.874C>T	c.(874-876)CAG>TAG	p.Q292*	EED_uc010rtm.1_Nonsense_Mutation_p.Q292*|EED_uc001pbq.2_Nonsense_Mutation_p.Q292*|EED_uc001pbr.2_Nonsense_Mutation_p.Q292*|EED_uc001pbs.2_Intron|EED_uc010rtn.1_Intron	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	292	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				ATTTATTTCTCAGAAAATCCA	0.299													71	71					0	0	0	0	T	85979511	T	T	85979511	4	4	4	1	0	0	0	0	0	1	0	0	4944	827	29	2	908	2	EED	11	85979511	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	15808977	85979511	49027005	212	974											
GRM5	2915	broad.mit.edu	37	chr11	88300894	88300894	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagctcatggctggggagaGaccaatgccaattctctgaa	11	9	12	9	0	2	2	1	1	1	1	3	4	2	3	2	3	2	3	2	3	4	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:88300894G>C	uc001pcq.2	-	7	2157	c.1957C>G	c.(1957-1959)CTC>GTC	p.L653V	GRM5_uc009yvm.2_Missense_Mutation_p.L653V	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	653	Helical; Name=3; (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GCTGGGGAGAGACCAATGCCA	0.493													16	12					0	0	0	0	C	88300894	C	C	88300894	3	2	4	1	0	0	0	0	1	0	0	0	6839	942	33	2	1693	2	GRM5	11	88300894	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2321383	88300894	46705622	213	975											
CBL	867	broad.mit.edu	37	chr11	119103214	119103214	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaatagcccaccttatatCttagacctgctaccagatac	14	10	5	12	0	1	3	0	0	1	3	1	3	1	3	4	0	4	1	4	0	8	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:119103214C>T	uc001pwe.2	+	2	390	c.252C>T	c.(250-252)ATC>ATT	p.I84I		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	84	Cbl-PTB.|4H.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CACCTTATATCTTAGACCTGC	0.428									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				7	67					0	0	0	0	T	119103214	T	T	119103214	2	4	4	1	0	0	0	0	0	0	0	1	2712	903	32	2		2	CBL	11	119103214	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	30802320	119103214	15903302	214	976											
TECTA	7007	broad.mit.edu	37	chr11	120998984	120998984	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgcaggacctgcttggctGcggggacttcggatcctggt	5	10	16	10	2	0	0	0	0	0	0	2	4	1	3	2	6	3	3	2	6	0	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr11:120998984G>A	uc010rzo.1	+	8	2298	c.2298G>A	c.(2296-2298)CTG>CTA	p.L766L		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	766	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CTGCTTGGCTGCGGGGACTTC	0.587													21	63					0	0	0	0	A	120998984	A	A	120998984	2	1	4	1	0	0	0	0	0	0	0	1	15813	1306	46	4		4	TECTA	11	120998984	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1895770	120998984	14007532	215	977											
SLC6A13	6540	broad.mit.edu	37	chr12	351877	351877	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccaacacaatgatgtagtaGacgttgaggaggatgacgat	14	8	13	6	2	0	4	0	3	0	1	0	7	0	6	1	2	1	3	1	2	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:351877G>C	uc001qic.1	-	4	434	c.381C>G	c.(379-381)GTC>GTG	p.V127V	SLC6A13_uc009zdj.1_Silent_p.V127V|SLC6A13_uc010sdl.1_Intron|SLC6A13_uc010sdm.1_Silent_p.V8V	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	127	Helical; Name=3; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TGATGTAGTAGACGTTGAGGA	0.512													4	11					0	0	0	0	C	351877	C	C	351877	2	2	4	1	0	0	0	0	0	0	0	1	14740	929	33	2		2	SLC6A13	12	351877	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08		351877	133500018	216	978											
CD163L1	283316	broad.mit.edu	37	chr12	7556331	7556331	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gctgcttacaaaccacaaggGcttgttcattcttccagttc	9	13	7	12	0	2	0	1	0	1	0	4	0	3	0	2	1	3	5	2	1	3	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:7556331G>A	uc001qsy.2	-	6	1234	c.1208C>T	c.(1207-1209)GCC>GTC	p.A403V	CD163L1_uc010sge.1_Missense_Mutation_p.A413V	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	403	SRCR 4.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						AACCACAAGGGCTTGTTCATT	0.443													86	137					0	0	0	0	A	7556331	A	A	7556331	3	1	4	1	0	0	0	0	1	0	0	0	2983	1203	42	4	3209	4	CD163L1	12	7556331	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	7204454	7556331	126295564	217	979											
FOXJ2	55810	broad.mit.edu	37	chr12	8196363	8196363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagacaccctccagatgatGatgtaagttcccagctcatg	12	9	9	11	0	1	4	1	2	0	2	3	5	3	4	3	0	1	3	3	0	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:8196363G>A	uc001qtu.2	+	4	1560	c.475G>A	c.(475-477)GAT>AAT	p.D159N	FOXJ2_uc001qtt.1_Missense_Mutation_p.D159N	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	159					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				Kidney(36;0.0944)		TCCAGATGATGATGTAAGTTC	0.493													19	268					0	0	0	0	A	8196363	A	A	8196363	3	1	4	1	0	0	0	0	1	0	0	0	6046	1290	45	2	485	2	FOXJ2	12	8196363	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	640032	8196363	125655532	218	980											
KLRG1	10219	broad.mit.edu	37	chr12	9161668	9161668	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggatcacctctaaacttctCaaggtaaggggcttcaaagg	12	10	10	9	0	4	0	3	0	2	0	5	1	4	1	1	5	1	2	1	5	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:9161668C>T	uc001qvh.2	+	4	466	c.455C>T	c.(454-456)TCA>TTA	p.S152L	KLRG1_uc001qvg.2_Missense_Mutation_p.S152L	NM_005810	NP_005801	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G,	152	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			central_nervous_system(1)	1						CTAAACTTCTCAAGGTAAGGG	0.289													18	24					0	0	0	0	T	9161668	T	T	9161668	3	4	4	1	0	0	0	0	1	0	0	0	8460	838	29	2	469	2	KLRG1	12	9161668	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	965305	9161668	124690227	219	981											
LRP6	4040	broad.mit.edu	37	chr12	12312019	12312019	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggctccagtccgtccagtaGatataatcttggtactgagt	9	12	10	10	2	1	2	0	1	1	1	4	2	4	2	3	2	1	3	3	2	4	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:12312019G>C	uc001rah.3	-	12	2677	c.2535C>G	c.(2533-2535)ATC>ATG	p.I845M	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.I845M	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	845	Extracellular (Potential).|Beta-propeller 3.|LDL-receptor class B 15.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CCGTCCAGTAGATATAATCTT	0.483													16	41					0	0	0	0	C	12312019	C	C	12312019	3	2	4	1	0	0	0	0	1	0	0	0	9012	932	33	2	2354	2	LRP6	12	12312019	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	3150351	12312019	121539876	220	982											
ATF7IP	55729	broad.mit.edu	37	chr12	14649234	14649234	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actaaccctgggatcaacagGacctcagctcacagtgcatc	12	7	8	14	0	3	0	3	0	0	0	4	2	3	2	2	2	4	2	2	2	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:14649234G>A	uc001rbw.2	+	14	3508	c.3350G>A	c.(3349-3351)GGA>GAA	p.G1117E	ATF7IP_uc001rbx.2_Missense_Mutation_p.G1116E|ATF7IP_uc001rby.3_Missense_Mutation_p.G1117E|ATF7IP_uc001rca.2_Missense_Mutation_p.G1117E	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	1117					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						GGATCAACAGGACCTCAGCTC	0.388													16	33					0	0	0	0	A	14649234	A	A	14649234	3	1	4	1	0	0	0	0	1	0	0	0	1089	1174	41	2	3400	2	ATF7IP	12	14649234	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2337215	14649234	119202661	221	983											
PDE3A	5139	broad.mit.edu	37	chr12	20806970	20806970	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccttcaggaatccttcatCtctcacattgtggggcctct	8	13	7	13	0	5	0	3	0	2	0	7	1	6	1	3	3	1	0	3	3	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:20806970C>G	uc001reh.1	+	15	3037	c.3015C>G	c.(3013-3015)ATC>ATG	p.I1005M		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	1005	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AATCCTTCATCTCTCACATTG	0.498													11	75					0	0	0	0	G	20806970	G	G	20806970	3	3	4	1	0	0	0	0	1	0	0	0	11691	903	32	2	3073	2	PDE3A	12	20806970	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	6157736	20806970	113044925	222	984											
C12orf41	54934	broad.mit.edu	37	chr12	49075374	49075374	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgggcactggagtgatcctCccccgattggttggcaagac	7	9	13	12	1	0	2	0	1	0	1	2	4	2	3	3	4	0	3	3	4	1	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:49075374C>A	uc001rrx.2	-	2	117	c.42G>T	c.(40-42)GGG>GGT	p.G14G	C12orf41_uc001rrw.2_5'Flank|C12orf41_uc001rrz.2_Silent_p.G197G|C12orf41_uc001rry.2_RNA	NM_017822	NP_060292	Q9H9L4	CL041_HUMAN	hypothetical protein LOC54934	14										ovary(2)	2						GAGTGATCCTCCCCCGATTGG	0.517													12	86					7.93312e-07	8.25422e-07	1	0	A	49075374	A	A	49075374	2	1	4	1	0	0	0	0	0	0	0	1	1693	842	30	2		2	C12orf41	12	49075374	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	28268404	49075374	84776521	223	985											
CACNB3	784	broad.mit.edu	37	chr12	49219528	49219528	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaagaggaccatcattgagCgctcctctgcccgctccagc	8	7	10	16	2	2	2	1	1	1	1	4	3	4	3	4	1	3	3	4	1	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:49219528C>T	uc001rsl.1	+	9	919	c.718C>T	c.(718-720)CGC>TGC	p.R240C	CACNB3_uc010sly.1_Missense_Mutation_p.R227C|CACNB3_uc010slz.1_Missense_Mutation_p.R239C|CACNB3_uc001rsk.1_Missense_Mutation_p.R87C	NM_000725	NP_000716	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3	240					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0					Verapamil(DB00661)	CATCATTGAGCGCTCCTCTGC	0.567													20	77					0	0	0	0	T	49219528	T	T	49219528	3	4	4	1	0	0	0	0	1	0	0	0	2566	768	27	1	752	1	CACNB3	12	49219528	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	144154	49219528	84632367	224	986											
MLL2	8085	broad.mit.edu	37	chr12	49443980	49443980	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aggctctggctgtgaacccgGagcatcaatcccatccagag	10	7	11	13	1	2	2	1	1	1	1	4	3	4	3	3	3	2	3	3	3	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:49443980G>C	uc001rta.3	-	11	3391	c.3391C>G	c.(3391-3393)CCG>GCG	p.P1131A		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1131	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGTGAACCCGGAGCATCAATC	0.637			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			22	30					0	0	0	0	C	49443980	C	C	49443980	3	2	4	1	0	0	0	0	1	0	0	0	9674	1174	41	2	13398	2	MLL2	12	49443980	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	224452	49443980	84407915	225	987											
TFCP2	7024	broad.mit.edu	37	chr12	51504737	51504739	+	In_Frame_Del	DEL	GAT	-	-																															ttgagttggattagccctagGatcgattatacccacagaca																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:51504737_51504739delGAT	uc001rxw.2	-	5	944_946	c.485_487delATC	c.(484-489)GATCCT>GCT	p.162_163DP>A	TFCP2_uc001rxv.1_In_Frame_Del_p.162_163DP>A|TFCP2_uc009zlx.1_In_Frame_Del_p.162_163DP>A|TFCP2_uc001rxx.2_In_Frame_Del_p.162_163DP>A|TFCP2_uc009zly.1_In_Frame_Del_p.64_65DP>A	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	162_163	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTAGCCCTAGGATCGATTATACC	0.409													---	---	---								-	51504739	-	-	51504737	7	5	4	1	0	1	0	1	0	0	0	0	15861	1174	41	0	1065	0	TFCP2	12	51504737	In_Frame_Del	DEL	GAT	TCGA-BA-4077-01B-01D-1434-08	2060757	51504737	82347158	226	988											
ESPL1	9700	broad.mit.edu	37	chr12	53687204	53687204	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgccaagctccccgactcaaGtatcttattggggctgcacc	8	9	9	15	2	2	0	1	0	1	0	3	1	3	0	4	2	2	4	4	2	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:53687204G>C	uc001sck.2	+	31	6400	c.6309G>C	c.(6307-6309)AAG>AAC	p.K2103N	ESPL1_uc001scj.2_Missense_Mutation_p.K1778N|PFDN5_uc001scl.2_5'Flank|PFDN5_uc001scm.2_5'Flank|PFDN5_uc001scn.2_5'Flank|PFDN5_uc001sco.2_5'Flank	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	2103					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CCCGACTCAAGTATCTTATTG	0.557													21	89					0	0	0	0	C	53687204	C	C	53687204	3	2	4	1	0	0	0	0	1	0	0	0	5277	1020	36	4	6427	4	ESPL1	12	53687204	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2182467	53687204	80164691	227	989											
OBFC2B	79035	broad.mit.edu	37	chr12	56620162	56620162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagaacgacagcaacccttCagcttcccagcctaccactg	11	6	7	17	1	1	1	1	0	0	1	2	2	2	1	4	0	6	3	4	0	3	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:56620162C>T	uc001ski.2	+	6	519	c.395C>T	c.(394-396)TCA>TTA	p.S132L	OBFC2B_uc001skk.2_Missense_Mutation_p.S157L|OBFC2B_uc001skj.2_Missense_Mutation_p.S148L	NM_024068	NP_076973	Q9BQ15	SOSB1_HUMAN	oligonucleotide/oligosaccharide-binding fold	132					double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	protein binding|single-stranded DNA binding			ovary(1)	1						AGCAACCCTTCAGCTTCCCAG	0.537								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					25	143					0	0	0	0	T	56620162	T	T	56620162	3	4	4	1	0	0	0	0	1	0	0	0	10863	838	29	2	413	2	OBFC2B	12	56620162	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2932958	56620162	77231733	228	990											
GLS2	27165	broad.mit.edu	37	chr12	56865620	56865620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atttaacaacttcgatgtgtCctaggaatatgggcagaagg	13	11	11	6	1	0	1	0	0	0	1	2	3	1	2	1	3	2	1	1	3	6	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:56865620C>T	uc001slj.2	-	17	1868	c.1589G>A	c.(1588-1590)GGA>GAA	p.G530E	GLS2_uc009zos.2_RNA|GLS2_uc001slk.2_Missense_Mutation_p.G265E|GLS2_uc009zot.2_Missense_Mutation_p.G191E	NM_013267	NP_037399	Q9UI32	GLSL_HUMAN	glutaminase 2 precursor	530	ANK 1.				cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			ovary(1)|central_nervous_system(1)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TTCGATGTGTCCTAGGAATAT	0.483													69	150					0	0	0	0	T	56865620	T	T	56865620	3	4	4	1	0	0	0	0	1	0	0	0	6501	869	30	2	227	2	GLS2	12	56865620	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	245458	56865620	76986275	229	991											
NAB2	4665	broad.mit.edu	37	chr12	57485044	57485044	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgacgtgcagcagctgtgtGaggcgggtgaggaggagttt	8	8	19	6	3	0	2	0	2	0	0	0	5	0	4	0	4	3	4	0	4	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:57485044G>C	uc001smz.2	+	2	598	c.220G>C	c.(220-222)GAG>CAG	p.E74Q		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	74	NCD1.				cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCAGCTGTGTGAGGCGGGTGA	0.632													25	219					0	0	0	0	C	57485044	C	C	57485044	3	2	4	1	0	0	0	0	1	0	0	0	10185	1291	45	2	226	2	NAB2	12	57485044	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	619424	57485044	76366851	230	992											
DPY19L2	283417	broad.mit.edu	37	chr12	63974572	63974572	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcactgttaaaatgccaaaGataaccttctcaaaacgaac	18	9	4	10	1	2	1	2	0	1	1	3	2	2	1	2	0	4	1	2	0	7	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:63974572G>C	uc001srp.1	-	19	1951	c.1770C>G	c.(1768-1770)ATC>ATG	p.I590M	DPY19L2_uc010sso.1_Missense_Mutation_p.I37M	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	590					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AAATGCCAAAGATAACCTTCT	0.373													29	86					0	0	0	0	C	63974572	C	C	63974572	3	2	4	1	0	0	0	0	1	0	0	0	4763	932	33	2	522	2	DPY19L2	12	63974572	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	6489528	63974572	69877323	231	993											
LRRC10	376132	broad.mit.edu	37	chr12	70004349	70004349	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtgcacaccacctggggCagagccttgaagttgttgaa	11	8	13	9	0	0	3	0	2	0	1	0	3	0	3	3	3	2	4	3	3	3	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:70004349C>A	uc001svc.2	-	1	594	c.270G>T	c.(268-270)CTG>CTT	p.L90L		NM_201550	NP_963844	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	90	LRR 2.					nucleus					0	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			CCACCTGGGGCAGAGCCTTGA	0.562													23	56					3.62473e-10	3.83537e-10	1	0	A	70004349	A	A	70004349	2	1	4	1	0	0	0	0	0	0	0	1	9017	697	25	4		4	LRRC10	12	70004349	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	6029777	70004349	63847546	232	994											
NUP37	79023	broad.mit.edu	37	chr12	102492898	102492898	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatacctgcaggtgtgatcGtcactcacacttgcaatttc	10	12	7	12	1	2	1	2	1	0	0	4	1	2	1	1	1	3	2	1	1	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:102492898G>A	uc001tjc.2	-	4	500	c.435C>T	c.(433-435)GAC>GAT	p.D145D	NUP37_uc009zub.1_Silent_p.D145D	NM_024057	NP_076962	Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	145	WD 2.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			ovary(1)	1						AGGTGTGATCGTCACTCACAC	0.343													34	62					0	0	0	0	A	102492898	A	A	102492898	2	1	4	1	0	0	0	0	0	0	0	1	10818	1136	40	1		1	NUP37	12	102492898	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	32488549	102492898	31358997	233	995											
CRY1	1407	broad.mit.edu	37	chr12	107393468	107393468	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccatggaaagcctgtccggCcttccgcccatttggctaaa	8	10	9	14	2	0	0	0	0	0	0	3	1	3	1	6	3	1	1	6	3	3	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:107393468C>T	uc001tmi.3	-	7	1857	c.998G>A	c.(997-999)GGC>GAC	p.G333D		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	333	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						GCCTGTCCGGCCTTCCGCCCA	0.473													27	45					0	0	0	0	T	107393468	T	T	107393468	3	4	4	1	0	0	0	0	1	0	0	0	3918	739	26	4	786	4	CRY1	12	107393468	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	4900570	107393468	26458427	234	996											
TCTN1	79600	broad.mit.edu	37	chr12	111078307	111078307	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacactttagcctttgcgtGaatgttgttcttgaggtagg	7	15	13	6	1	1	2	0	2	1	0	1	3	1	3	1	3	2	3	1	3	3	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:111078307G>C	uc009zvs.2	+	8	1071	c.963G>C	c.(961-963)GTG>GTC	p.V321V	TCTN1_uc009zvr.1_RNA|TCTN1_uc001trl.2_RNA|TCTN1_uc001trm.2_Silent_p.V261V|TCTN1_uc010syc.1_RNA|TCTN1_uc001tro.2_RNA|TCTN1_uc001trp.3_Silent_p.V307V|TCTN1_uc001trn.3_Silent_p.V321V|TCTN1_uc001trj.1_Silent_p.V265V|TCTN1_uc001trk.3_RNA|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	321					multicellular organismal development	extracellular region					0						GCCTTTGCGTGAATGTTGTTC	0.542													16	101					0	0	0	0	C	111078307	C	C	111078307	2	2	4	1	0	0	0	0	0	0	0	1	15788	1277	45	2		2	TCTN1	12	111078307	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	3684839	111078307	22773588	235	997											
CCDC63	160762	broad.mit.edu	37	chr12	111336787	111336787	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatatgtatgagagcaagtaCggggaggtcagcaagacctt	13	8	14	6	1	1	2	1	1	0	2	1	5	1	3	1	3	3	4	1	3	5	4	rs141258896		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:111336787C>T	uc001trv.1	+	10	1395	c.1200C>T	c.(1198-1200)TAC>TAT	p.Y400Y	CCDC63_uc010sye.1_Silent_p.Y360Y|CCDC63_uc001trw.1_Silent_p.Y315Y	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	400	Potential.									skin(6)|ovary(1)|pancreas(1)	8						AGAGCAAGTACGGGGAGGTCA	0.512													16	74					0	0	0	0	T	111336787	T	T	111336787	2	4	4	1	0	0	0	0	0	0	0	1	2847	547	19	1		1	CCDC63	12	111336787	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	258480	111336787	22515108	236	998											
CCDC63	160762	broad.mit.edu	37	chr12	111345227	111345227	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaggaagtgcgcggagacAgcctgcctgagaaggtggat	11	6	17	7	2	0	2	0	1	0	2	0	6	0	4	2	4	3	1	2	4	3	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:111345227A>G	uc001trv.1	+	12	1834	c.1639A>G	c.(1639-1641)AGC>GGC	p.S547G	CCDC63_uc010sye.1_Missense_Mutation_p.S507G|CCDC63_uc001trw.1_Missense_Mutation_p.S462G	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	547										skin(6)|ovary(1)|pancreas(1)	8						GCGCGGAGACAGCCTGCCTGA	0.517													7	50					0	0	0	0	G	111345227	G	G	111345227	3	3	4	1	0	0	0	0	1	0	0	0	2847	188	7	5	1681	5	CCDC63	12	111345227	Missense_Mutation	SNP	A	TCGA-BA-4077-01B-01D-1434-08	8440	111345227	22506668	237	999											
CCDC64	92558	broad.mit.edu	37	chr12	120530923	120530923	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggggggatgagcccagcatCgctgaaggcaaacgactctt	10	6	14	11	3	1	2	0	2	1	0	2	4	1	3	1	4	3	3	1	4	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:120530923C>T	uc001txl.1	+	9	1705	c.1680C>T	c.(1678-1680)ATC>ATT	p.I560I	CCDC64_uc009zwv.1_RNA|CCDC64_uc010sze.1_Silent_p.I231I|CCDC64_uc010szf.1_Silent_p.I257I	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	560					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGCCCAGCATCGCTGAAGGCA	0.602													5	35					0	0	0	0	T	120530923	T	T	120530923	2	4	4	1	0	0	0	0	0	0	0	1	2848	874	31	1		1	CCDC64	12	120530923	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	9185696	120530923	13320972	238	1000											
SNRNP35	11066	broad.mit.edu	37	chr12	123950297	123950297	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggacaaattaaaggaagtCttttcccgctatggtgacat	13	11	10	7	1	1	1	0	1	1	0	2	4	2	3	1	3	0	1	1	3	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:123950297C>G	uc001ufb.1	+	2	326	c.210C>G	c.(208-210)GTC>GTG	p.V70V	SNRNP35_uc010tar.1_Silent_p.V75V|SNRNP35_uc009zxz.2_Silent_p.V75V|SNRNP35_uc001ufc.1_Intron	NM_022717	NP_073208	Q16560	U1SBP_HUMAN	small nuclear ribonucleoprotein 35kDa (U11/U12)	70	RRM.				mRNA processing	U12-type spliceosomal complex	nucleotide binding|RNA binding				0						TAAAGGAAGTCTTTTCCCGCT	0.517													27	46					0	0	0	0	G	123950297	G	G	123950297	2	3	4	1	0	0	0	0	0	0	0	1	14919	900	32	2		2	SNRNP35	12	123950297	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	3419374	123950297	9901598	239	1001											
TMEM132B	114795	broad.mit.edu	37	chr12	126135268	126135268	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacgaggacgatgaggagaaGaagggacgaggctgctccct	12	4	17	8	3	0	3	0	1	0	2	1	10	1	5	1	4	1	2	1	4	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:126135268G>C	uc001uhe.1	+	7	1676	c.1668G>C	c.(1666-1668)AAG>AAC	p.K556N	TMEM132B_uc001uhf.1_Missense_Mutation_p.K68N	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	556	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		ATGAGGAGAAGAAGGGACGAG	0.552													4	103					0	0	0	0	C	126135268	C	C	126135268	3	2	4	1	0	0	0	0	1	0	0	0	16112	933	33	2	1694	2	TMEM132B	12	126135268	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2184971	126135268	7716627	240	1002											
TMEM132D	121256	broad.mit.edu	37	chr12	129566558	129566558	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgctcatcatcctcctcctCttcactgtccccggcaggcc	4	10	6	21	2	4	0	3	0	1	0	8	0	8	0	7	2	0	2	7	2	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:129566558C>G	uc009zyl.1	-	7	1997	c.1669G>C	c.(1669-1671)GAG>CAG	p.E557Q	TMEM132D_uc001uia.2_Missense_Mutation_p.E95Q	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	557	Extracellular (Potential).					integral to membrane		p.E557E(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCCTCCTCCTCTTCACTGTCC	0.642													18	96					0	0	0	0	G	129566558	G	G	129566558	3	3	4	1	0	0	0	0	1	0	0	0	16113	922	32	2	1642	2	TMEM132D	12	129566558	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	3431290	129566558	4285337	241	1003											
ANKLE2	23141	broad.mit.edu	37	chr12	133306305	133306305	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggccggttccctggtgacctCgagctgatcctcgtgcctgg	3	10	14	14	3	0	2	0	2	0	0	4	3	2	2	5	4	2	2	5	4	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr12:133306305C>G	uc001ukx.2	-	11	2510	c.2443G>C	c.(2443-2445)GAG>CAG	p.E815Q	ANKLE2_uc009zyw.1_Missense_Mutation_p.E170Q	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	815						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		CTGGTGACCTCGAGCTGATCC	0.448													10	154					0	0	0	0	G	133306305	G	G	133306305	3	3	4	1	0	0	0	0	1	0	0	0	633	893	31	3	385	3	ANKLE2	12	133306305	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	3739747	133306305	545590	242	1004											
FRY	10129	broad.mit.edu	37	chr13	32818298	32818298	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaatgtggaagttctgaaGacaattgaaaaatatgtgca	16	12	9	4	0	2	3	1	2	1	1	2	4	2	4	0	1	1	2	0	1	7	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr13:32818298G>C	uc001utx.2	+	47	7303	c.6807G>C	c.(6805-6807)AAG>AAC	p.K2269N	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2269					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AAGTTCTGAAGACAATTGAAA	0.438													23	115					0	0	0	0	C	32818298	C	C	32818298	3	2	4	1	0	0	0	0	1	0	0	0	6097	933	33	2	6993	2	FRY	13	32818298	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08		32818298	82351580	243	1005											
UGGT2	55757	broad.mit.edu	37	chr13	96592328	96592328	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgagtatattttgatccttCttcactttttggtacatctg	7	20	7	7	0	3	2	1	2	2	0	4	2	4	2	1	1	1	2	1	1	3	9			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr13:96592328C>G	uc001vmt.2	-	16	1865	c.1695G>C	c.(1693-1695)AAG>AAC	p.K565N		NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	565					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						TTTGATCCTTCTTCACTTTTT	0.279													5	126					0	0	0	0	G	96592328	G	G	96592328	3	3	4	1	0	0	0	0	1	0	0	0	17010	912	32	2	2951	2	UGGT2	13	96592328	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	63774030	96592328	18577550	244	1006											
NALCN	259232	broad.mit.edu	37	chr13	101756771	101756771	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatatcacaaacacatactCagcaatctgaaacgggcaaa	19	6	6	10	1	3	1	2	1	1	0	3	2	3	1	0	1	4	2	0	1	7	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr13:101756771C>T	uc001vox.1	-	25	2953	c.2764G>A	c.(2764-2766)GAG>AAG	p.E922K		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	922	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AACACATACTCAGCAATCTGA	0.423													6	101					0	0	0	0	T	101756771	T	T	101756771	3	4	4	1	0	0	0	0	1	0	0	0	10201	835	29	2	2532	2	NALCN	13	101756771	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	5164443	101756771	13413107	245	1007											
OR4N2	390429	broad.mit.edu	37	chr14	20295739	20295739	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctccctggaaattttctCattattttcaccataaagtc	11	16	3	11	0	2	0	2	0	1	0	6	1	4	1	3	1	0	0	3	1	4	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:20295739C>T	uc010tkv.1	+	1	132	c.132C>T	c.(130-132)CTC>CTT	p.L44L		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GAAATTTTCTCATTATTTTCA	0.448													118	271					0	0	0	0	T	20295739	T	T	20295739	2	4	4	1	0	0	0	0	0	0	0	1	11131	813	29	2		2	OR4N2	14	20295739	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08		20295739	87053801	246	1008											
OR4K15	81127	broad.mit.edu	37	chr14	20444245	20444245	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttggcattcactgttaatCtgccattttgtggtcctaat	8	17	8	8	0	2	0	1	0	1	0	3	0	3	0	2	2	1	3	2	2	2	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:20444245C>G	uc010tkx.1	+	1	568	c.568C>G	c.(568-570)CTG>GTG	p.L190V		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CACTGTTAATCTGCCATTTTG	0.438													78	219					0	0	0	0	G	20444245	G	G	20444245	3	3	4	1	0	0	0	0	1	0	0	0	11124	912	32	2	570	2	OR4K15	14	20444245	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	148506	20444245	86905295	247	1009											
TOX4	9878	broad.mit.edu	37	chr14	21963395	21963395	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcttctcacaggttgagtCtccttctcagatggatgttg	6	16	9	10	0	4	2	2	1	4	1	7	3	4	3	1	2	0	2	1	2	0	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:21963395C>G	uc001waz.2	+	8	1752	c.1649C>G	c.(1648-1650)TCT>TGT	p.S550C	TOX4_uc001way.2_Missense_Mutation_p.S420C|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Missense_Mutation_p.S527C|TOX4_uc010tlv.1_Missense_Mutation_p.S420C	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	550						chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		CAGGTTGAGTCTCCTTCTCAG	0.483													63	168					0	0	0	0	G	21963395	G	G	21963395	3	3	4	1	0	0	0	0	1	0	0	0	16447	913	32	2	1679	2	TOX4	14	21963395	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1519150	21963395	85386145	248	1010											
DLGAP5	9787	broad.mit.edu	37	chr14	55625360	55625360	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttcctgcctaattctctCtctcattgcattttttatgg	5	21	4	11	0	4	0	1	0	3	0	7	0	5	0	2	1	2	1	2	1	2	8			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:55625360C>G	uc001xbs.2	-	14	1970	c.1753G>C	c.(1753-1755)GAG>CAG	p.E585Q	DLGAP5_uc001xbt.2_Missense_Mutation_p.E585Q	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	585					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						CTAATTCTCTCTCTCATTGCA	0.393													40	87					0	0	0	0	G	55625360	G	G	55625360	3	3	4	1	0	0	0	0	1	0	0	0	4585	922	32	2	906	2	DLGAP5	14	55625360	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	33661965	55625360	51724180	249	1011											
DLGAP5	9787	broad.mit.edu	37	chr14	55643828	55643828	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aactgggtgtcaaaaaagcaTtggcacttctgggagtcata	13	10	11	7	0	3	0	2	0	1	0	3	1	3	1	0	3	2	2	0	3	5	3	rs139172891		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:55643828T>C	uc001xbs.2	-	8	1218	c.1001A>G	c.(1000-1002)AAT>AGT	p.N334S	DLGAP5_uc001xbt.2_Missense_Mutation_p.N334S	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	334					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						CAAAAAAGCATTGGCACTTCT	0.378													30	64					0	0	0	0	C	55643828	C	C	55643828	3	2	4	1	0	0	0	0	1	0	0	0	4585	1493	52	5	1682	5	DLGAP5	14	55643828	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	18468	55643828	51705712	250	1012											
SPTB	6710	broad.mit.edu	37	chr14	65233386	65233386	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggctgagcctagtaggggtGagagggctctggctgcagtg	6	8	20	7	0	1	2	0	2	1	1	1	3	1	2	1	5	2	5	1	5	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:65233386G>C	uc001xht.2	-	31	6457	c.6403C>G	c.(6403-6405)CAC>GAC	p.H2135D	SPTB_uc001xhr.2_Intron|SPTB_uc001xhs.2_Intron|SPTB_uc001xhu.2_Missense_Mutation_p.H2135D|SPTB_uc010aqi.2_Intron	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	2135					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TAGTAGGGGTGAGAGGGCTCT	0.652													41	233					0	0	0	0	C	65233386	C	C	65233386	3	2	4	1	0	0	0	0	1	0	0	0	15184	1290	45	2	672	2	SPTB	14	65233386	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	9589558	65233386	42116154	251	1013											
ZFP36L1	677	broad.mit.edu	37	chr14	69256568	69256568	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagcccaggaggtcatcggcGctcagaatagggggtggggt	8	6	19	8	2	2	1	2	0	0	1	3	3	2	2	1	7	1	1	1	7	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:69256568G>A	uc001xkh.1	-	2	829	c.699C>T	c.(697-699)AGC>AGT	p.S233S	ZFP36L1_uc001xki.1_Silent_p.S233S	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	233					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GGTCATCGGCGCTCAGAATAG	0.522											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	269					0	0	0	0	A	69256568	A	A	69256568	2	1	4	1	0	0	0	0	0	0	0	1	17713	1078	38	1		1	ZFP36L1	14	69256568	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	4023182	69256568	38092972	252	1014											
DCAF5	8816	broad.mit.edu	37	chr14	69520744	69520744	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggggtctcacaggccatttCagacccgcaacaatctttgt	9	10	10	12	1	3	1	2	0	2	1	4	1	3	1	2	3	1	1	2	3	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:69520744C>T	uc001xkp.2	-	9	2878	c.2659G>A	c.(2659-2661)GAA>AAA	p.E887K	DCAF5_uc001xkq.2_Missense_Mutation_p.E886K	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	887						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2						CAGGCCATTTCAGACCCGCAA	0.567													19	193					0	0	0	0	T	69520744	T	T	69520744	3	4	4	1	0	0	0	0	1	0	0	0	4290	835	29	2	173	2	DCAF5	14	69520744	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	264176	69520744	37828796	253	1015											
SFRS5	6430	broad.mit.edu	37	chr14	70235606	70235606	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagtcgcagacctcgaaatGatagacggtatgtgaagggt	12	9	14	6	3	0	4	0	2	0	2	2	5	0	4	1	2	0	3	1	2	5	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:70235606G>A	uc001xll.2	+	5	1740	c.289G>A	c.(289-291)GAT>AAT	p.D97N	SFRS5_uc001xlm.2_RNA|SFRS5_uc001xln.1_Missense_Mutation_p.D97N|SFRS5_uc001xlo.2_Missense_Mutation_p.D97N|SFRS5_uc001xlp.2_Missense_Mutation_p.D97N|SFRS5_uc001xlq.2_Missense_Mutation_p.D94N	NM_006925	NP_008856	Q13243	SRSF5_HUMAN	splicing factor, arginine/serine-rich 5	97					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding				0				all cancers(60;0.00144)|BRCA - Breast invasive adenocarcinoma(234;0.0132)|OV - Ovarian serous cystadenocarcinoma(108;0.0154)		ACCTCGAAATGATAGACGGTA	0.453													28	108					0	0	0	0	A	70235606	A	A	70235606	3	1	4	1	0	0	0	0	1	0	0	0	14245	1290	45	2	299	2	SFRS5	14	70235606	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	714862	70235606	37113934	254	1016											
PCNX	22990	broad.mit.edu	37	chr14	71485846	71485846	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggtcttccagttctgcctCgtcatagccagctgtcaata	7	13	9	12	1	4	0	2	0	2	0	6	0	5	0	3	1	3	2	3	1	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:71485846C>T	uc001xmo.2	+	12	3563	c.3117C>T	c.(3115-3117)CTC>CTT	p.L1039L	PCNX_uc010are.1_Silent_p.L928L|PCNX_uc010arf.1_5'UTR	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1039	Helical; (Potential).					integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AGTTCTGCCTCGTCATAGCCA	0.423													48	323					0	0	0	0	T	71485846	T	T	71485846	2	4	4	1	0	0	0	0	0	0	0	1	11645	871	31	1		1	PCNX	14	71485846	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1250240	71485846	35863694	255	1017											
STON2	85439	broad.mit.edu	37	chr14	81743806	81743806	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attccctttgacgaggatgtCattgaggcccaggcggcact	8	10	12	11	2	1	2	1	2	0	0	2	4	2	3	2	4	0	1	2	4	0	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:81743806C>T	uc010tvu.1	-	4	2050	c.1849G>A	c.(1849-1851)GAC>AAC	p.D617N	STON2_uc001xvk.1_Missense_Mutation_p.D617N|STON2_uc010tvt.1_Missense_Mutation_p.D414N	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	617	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		ACGAGGATGTCATTGAGGCCC	0.532													17	142					0	0	0	0	T	81743806	T	T	81743806	3	4	4	1	0	0	0	0	1	0	0	0	15384	826	29	2	874	2	STON2	14	81743806	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	10257960	81743806	25605734	256	1018											
STON2	85439	broad.mit.edu	37	chr14	81743896	81743896	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgctggagaatctggttgtCtcctttgctcacaatgccag	7	13	11	10	0	3	1	1	0	2	1	4	2	3	1	2	2	3	3	2	2	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:81743896C>T	uc010tvu.1	-	4	1960	c.1759G>A	c.(1759-1761)GAC>AAC	p.D587N	STON2_uc001xvk.1_Missense_Mutation_p.D587N|STON2_uc010tvt.1_Missense_Mutation_p.D384N	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	587	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		ATCTGGTTGTCTCCTTTGCTC	0.507													14	152					0	0	0	0	T	81743896	T	T	81743896	3	4	4	1	0	0	0	0	1	0	0	0	15384	913	32	2	964	2	STON2	14	81743896	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	90	81743896	25605644	257	1019											
KIAA1409	57578	broad.mit.edu	37	chr14	94103615	94103615	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgccaacgtgcctaaaccctGacctggagggacagccattg	10	7	11	13	1	0	1	0	1	0	0	0	3	0	3	5	2	5	0	5	2	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:94103615G>C	uc001ybv.1	+	31	5505	c.5422G>C	c.(5422-5424)GAC>CAC	p.D1808H	KIAA1409_uc001ybs.1_Missense_Mutation_p.D1786H	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1963						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		cctaaaccctgacctggaggg	0													15	56					0	0	0	0	C	94103615	C	C	94103615	3	2	4	1	0	0	0	0	1	0	0	0	8269	1290	45	2	5474	2	KIAA1409	14	94103615	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	12359719	94103615	13245925	258	1020											
BDKRB1	623	broad.mit.edu	37	chr14	96730571	96730571	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccaagccgtcccagatctGaacatcaccgcctgcatcct	10	8	6	17	2	2	2	1	1	1	1	5	2	5	2	6	0	3	1	6	0	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:96730571G>C	uc001yfh.2	+	3	760	c.552G>C	c.(550-552)CTG>CTC	p.L184L	BDKRB1_uc010avn.2_Silent_p.L184L	NM_000710	NP_000701	P46663	BKRB1_HUMAN	bradykinin receptor B1	184	Extracellular (Potential).				elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			ovary(3)	3		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		TCCCAGATCTGAACATCACCG	0.592													32	175					0	0	0	0	C	96730571	C	C	96730571	2	2	4	1	0	0	0	0	0	0	0	1	1394	1277	45	2		2	BDKRB1	14	96730571	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2626956	96730571	10618969	259	1021											
ATG2B	55102	broad.mit.edu	37	chr14	96777489	96777489	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggctccaggcttcatatCtgccttgttaggtgtctgca	8	13	10	10	0	3	0	1	0	2	0	4	0	4	0	2	3	2	4	2	3	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr14:96777489C>T	uc001yfi.2	-	28	4491	c.4126G>A	c.(4126-4128)GAT>AAT	p.D1376N		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1376										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GGCTTCATATCTGCCTTGTTA	0.448													35	347					0	0	0	0	T	96777489	T	T	96777489	3	4	4	1	0	0	0	0	1	0	0	0	1096	913	32	2	2170	2	ATG2B	14	96777489	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	46918	96777489	10572051	260	1022											
RTF1	23168	broad.mit.edu	37	chr15	41762577	41762577	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcacgaacatcatcgtctGatgaagaagaggagtaagct	15	8	10	8	2	3	4	2	2	1	2	4	6	3	5	0	1	2	2	0	1	4	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:41762577G>T	uc001zny.2	+	7	1024	c.1012G>T	c.(1012-1014)GAT>TAT	p.D338Y		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	338	Glu-rich.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		ATCATCGTCTGATGAAGAAGA	0.443													41	369					9.39024e-22	1.03887e-21	1	0	T	41762577	T	T	41762577	3	4	4	1	0	0	0	0	1	0	0	0	13786	1290	45	2	1038	2	RTF1	15	41762577	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08		41762577	60768815	261	1023											
TP53BP1	7158	broad.mit.edu	37	chr15	43749026	43749026	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccctggtgtctgtatcatCtccctttgttttgtcatcat	5	19	6	11	0	5	0	3	0	2	0	7	0	6	0	2	1	0	2	2	1	1	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:43749026C>G	uc001zrs.2	-	12	1913	c.1765G>C	c.(1765-1767)GAT>CAT	p.D589H	TP53BP1_uc010udp.1_Missense_Mutation_p.D589H|TP53BP1_uc001zrq.3_Missense_Mutation_p.D594H|TP53BP1_uc001zrr.3_Missense_Mutation_p.D594H|TP53BP1_uc010udq.1_Missense_Mutation_p.D594H	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	589					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TCTGTATCATCTCCCTTTGTT	0.403								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					70	156					0	0	0	0	G	43749026	G	G	43749026	3	3	4	1	0	0	0	0	1	0	0	0	16450	913	32	2	4221	2	TP53BP1	15	43749026	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1986449	43749026	58782366	262	1024											
FBN1	2200	broad.mit.edu	37	chr15	48796097	48796097	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggtttgatacactggcctCtcttgtatccaccatagcat	10	13	7	11	0	1	1	0	1	1	0	3	1	2	1	3	2	2	3	3	2	4	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:48796097C>G	uc001zwx.1	-	17	2328	c.2000G>C	c.(1999-2001)AGA>ACA	p.R667T		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	667	TB 3.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACACTGGCCTCTCTTGTATCC	0.488													13	112					0	0	0	0	G	48796097	G	G	48796097	3	3	4	1	0	0	0	0	1	0	0	0	5734	913	32	2	6815	2	FBN1	15	48796097	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	5047071	48796097	53735295	263	1025											
SHC4	399694	broad.mit.edu	37	chr15	49176472	49176472	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcaagattcatcaatgtGagactgcatgttgagatggt	11	14	11	5	0	3	3	3	2	0	3	3	5	3	3	0	1	1	2	0	1	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:49176472G>T	uc001zxb.1	-	4	1242	c.813C>A	c.(811-813)CTC>CTA	p.L271L		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	271	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TCATCAATGTGAGACTGCATG	0.338													18	63					2.94398e-08	3.0926e-08	1	0	T	49176472	T	T	49176472	2	4	4	1	0	0	0	0	0	0	0	1	14338	1277	45	2		2	SHC4	15	49176472	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	380375	49176472	53354920	264	1026											
USP3	9960	broad.mit.edu	37	chr15	63866568	63866568	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagaagtaagcgctctaaGaatcaagaaaatggaccagt	17	8	9	7	1	3	3	2	0	1	3	3	4	3	4	1	1	1	2	1	1	7	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:63866568G>T	uc002amf.2	+	11	1191	c.1062G>T	c.(1060-1062)AAG>AAT	p.K354N	USP3_uc010uii.1_RNA|USP3_uc002amg.2_Missense_Mutation_p.K269N|USP3_uc002amh.2_Missense_Mutation_p.K332N|USP3_uc010uij.1_Missense_Mutation_p.K310N|USP3_uc010uik.1_Missense_Mutation_p.K105N|USP3_uc010bgs.2_Missense_Mutation_p.K337N|USP3_uc002ami.2_Missense_Mutation_p.K185N	NM_006537	NP_006528	Q9Y6I4	UBP3_HUMAN	ubiquitin thiolesterase 3	354					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(80;0.0187)		AGCGCTCTAAGAATCAAGAAA	0.323													4	77					0.00116845	0.00119862	1	0	T	63866568	T	T	63866568	3	4	4	1	0	0	0	0	1	0	0	0	17128	933	33	2	1104	2	USP3	15	63866568	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	14690096	63866568	38664824	265	1027											
HERC1	8925	broad.mit.edu	37	chr15	63966767	63966767	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtctgagttgtggccattTtcagccagaacttttggtat	8	15	10	8	0	2	2	1	1	1	1	2	2	2	2	2	2	2	2	2	2	2	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:63966767T>A	uc002amp.2	-	38	7768	c.7620A>T	c.(7618-7620)GAA>GAT	p.E2540D		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2540					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TGTGGCCATTTTCAGCCAGAA	0.483													9	18					0	0	0	0	A	63966767	A	A	63966767	3	1	4	1	0	0	0	0	1	0	0	0	7096	1838	64	5	7129	5	HERC1	15	63966767	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	100199	63966767	38564625	266	1028											
IGDCC4	57722	broad.mit.edu	37	chr15	65702644	65702644	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagactccgggtgcagagaGaagtctgcgagtgctgggga	9	7	18	7	2	1	3	0	1	1	3	2	7	2	4	1	3	3	2	1	3	1	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:65702644G>C	uc002aou.1	-	3	645	c.435C>G	c.(433-435)TTC>TTG	p.F145L		NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	145	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GGTGCAGAGAGAAGTCTGCGA	0.557													15	113					0	0	0	0	C	65702644	C	C	65702644	3	2	4	1	0	0	0	0	1	0	0	0	7608	933	33	2	3389	2	IGDCC4	15	65702644	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1735877	65702644	36828748	267	1029											
RPL4	6124	broad.mit.edu	37	chr15	66791763	66791763	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttatgcagcaggcttcttCtcctctgtagtaggtttctt	5	18	9	9	0	4	0	0	0	4	0	5	0	4	0	1	2	2	7	1	2	3	8			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:66791763C>T	uc002apv.2	-	10	1322	c.1266G>A	c.(1264-1266)GAG>GAA	p.E422E	SNAPC5_uc002apu.1_5'Flank|RPL4_uc010bhr.2_Silent_p.E328E|RPL4_uc002apw.2_Silent_p.E328E|RPL4_uc002apx.2_Silent_p.E328E	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	422	Lys-rich.				endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						CAGGCTTCTTCTCCTCTGTAG	0.413													9	156					0	0	0	0	T	66791763	T	T	66791763	2	4	4	1	0	0	0	0	0	0	0	1	13660	912	32	2		2	RPL4	15	66791763	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1089119	66791763	35739629	268	1030											
HCN4	10021	broad.mit.edu	37	chr15	73659999	73659999	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcctggcccaggcgcacctCggcctccgggaggatctggt	4	6	16	15	3	1	0	0	0	1	0	3	2	2	2	5	7	0	1	5	7	0	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:73659999C>T	uc002avp.2	-	1	1607	c.613G>A	c.(613-615)GAG>AAG	p.E205K		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	205	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		AGGCGCACCTCGGCCTCCGGG	0.682													7	61					0	0	0	0	T	73659999	T	T	73659999	3	4	4	1	0	0	0	0	1	0	0	0	7038	893	31	1	3030	1	HCN4	15	73659999	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	6868236	73659999	28871393	269	1031											
NPTN	27020	broad.mit.edu	37	chr15	73862516	73862516	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggaacctcatctggcctcttCctcttctcatacacaacaat	10	12	4	15	0	5	0	2	0	4	0	7	1	6	1	3	2	3	0	3	2	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:73862516C>T	uc002avs.2	-	6	1286	c.1089G>A	c.(1087-1089)AGG>AGA	p.R363R	NPTN_uc010bjc.2_Silent_p.R363R|NPTN_uc002avt.2_Silent_p.R247R|NPTN_uc002avr.2_Silent_p.R247R|NPTN_uc010ula.1_Silent_p.R158R	NM_012428	NP_036560	Q9Y639	NPTN_HUMAN	neuroplastin isoform b precursor	363	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding				0						CTGGCCTCTTCCTCTTCTCAT	0.512													42	285					0	0	0	0	T	73862516	T	T	73862516	2	4	4	1	0	0	0	0	0	0	0	1	10655	854	30	2		2	NPTN	15	73862516	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	202517	73862516	28668876	270	1032											
ETFA	2108	broad.mit.edu	37	chr15	76584999	76584999	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacatcatgctgagccaccaGaacttttgctatgcctgcta	10	11	7	13	0	1	2	1	1	0	1	1	2	1	2	3	0	6	3	3	0	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:76584999G>T	uc002bbt.2	-	3	310	c.229C>A	c.(229-231)CTG>ATG	p.L77M	ETFA_uc010bkq.1_Missense_Mutation_p.L28M|ETFA_uc002bbu.1_Missense_Mutation_p.L77M	NM_000126	NP_000117	P13804	ETFA_HUMAN	electron transfer flavoprotein, alpha	77					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity				0						TGAGCCACCAGAACTTTTGCT	0.358													33	176					1.60099e-16	1.73606e-16	1	0	T	76584999	T	T	76584999	3	4	4	1	0	0	0	0	1	0	0	0	5293	933	33	2	812	2	ETFA	15	76584999	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2722483	76584999	25946393	271	1033											
LINGO1	84894	broad.mit.edu	37	chr15	77906720	77906720	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agctgcgcacatgcaggtggGcgggcatggagtcgttgccg	6	7	18	10	4	0	0	0	0	0	0	1	1	0	1	1	4	4	5	1	4	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:77906720G>A	uc002bct.1	-	2	1581	c.1529C>T	c.(1528-1530)GCC>GTC	p.A510V	LINGO1_uc002bcu.1_Missense_Mutation_p.A504V	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	510	Extracellular (Potential).|Ig-like C2-type.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						ATGCAGGTGGGCGGGCATGGA	0.657													21	71					0	0	0	0	A	77906720	A	A	77906720	3	1	4	1	0	0	0	0	1	0	0	0	8856	1203	42	4	337	4	LINGO1	15	77906720	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1321721	77906720	24624672	272	1034											
ADAMTS7	11173	broad.mit.edu	37	chr15	79058055	79058055	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccgcggggggccccgcttCagccaggctgggagccagcg	4	4	18	15	4	1	0	1	0	0	0	2	1	2	1	5	5	3	2	5	5	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr15:79058055C>T	uc002bej.3	-	19	4409	c.4198G>A	c.(4198-4200)GAA>AAA	p.E1400K	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1400					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						GGCCCCGCTTCAGCCAGGCTG	0.692													15	154					0	0	0	0	T	79058055	T	T	79058055	3	4	4	1	0	0	0	0	1	0	0	0	271	835	29	2	886	2	ADAMTS7	15	79058055	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1151335	79058055	23473337	273	1035											
MSLNL	401827	broad.mit.edu	37	chr16	823207	823207	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtgtccaggttggttctGaggatgcagccatccaggca	8	9	15	9	0	1	1	0	1	1	0	3	2	3	2	3	5	2	4	3	5	0	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:823207G>T	uc002cjz.1	-	10	2061	c.2061C>A	c.(2059-2061)CTC>CTA	p.L687L		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	336	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						GGTTGGTTCTGAGGATGCAGC	0.627													11	137					1.61879e-10	1.72539e-10	1	0	T	823207	T	T	823207	2	4	4	1	0	0	0	0	0	0	0	1	9935	1277	45	2		2	MSLNL	16	823207	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08		823207	89531546	274	1036											
C16orf42	115939	broad.mit.edu	37	chr16	1400230	1400230	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caaaatgacagcaaggtctgGaaagcctgacggtgtgagaa	15	6	13	7	1	1	3	0	3	1	1	1	5	1	4	1	3	2	1	1	3	5	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:1400230G>C	uc002cll.2	-	4	600	c.532C>G	c.(532-534)CCA>GCA	p.P178A	GNPTG_uc002clm.2_5'Flank	NM_001001410	NP_001001410	Q9UJK0	TSR3_HUMAN	hypothetical protein LOC115939	178					rRNA processing						0		Hepatocellular(780;0.0893)				GCAAGGTCTGGAAAGCCTGAC	0.592													5	47					0	0	0	0	C	1400230	C	C	1400230	3	2	4	1	0	0	0	0	1	0	0	0	1819	1174	41	2	418	2	C16orf42	16	1400230	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	577023	1400230	88954523	275	1037											
CRAMP1L	57585	broad.mit.edu	37	chr16	1706343	1706343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcttgagaagacccctgcaGaaggcagggacagtcccacc	11	5	12	13	0	1	3	0	1	1	3	2	5	2	4	4	2	1	2	4	2	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:1706343G>A	uc010uvh.1	+	9	1585	c.1585G>A	c.(1585-1587)GAA>AAA	p.E529K	CRAMP1L_uc002cmf.2_Intron	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	529						nucleus	DNA binding				0						GACCCCTGCAGAAGGCAGGGA	0.677													10	19					0	0	0	0	A	1706343	A	A	1706343	3	1	4	1	0	0	0	0	1	0	0	0	3861	943	33	2	1619	2	CRAMP1L	16	1706343	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	306113	1706343	88648410	276	1038											
CP110	9738	broad.mit.edu	37	chr16	19543747	19543747	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgttttgcagcttaacattGagaaaagaaaggaaatgcaa	18	10	9	4	0	0	2	0	1	0	2	0	4	0	3	0	1	4	4	0	1	6	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:19543747G>C	uc002dgl.3	+	3	398	c.151G>C	c.(151-153)GAG>CAG	p.E51Q	CP110_uc002dgk.3_Missense_Mutation_p.E51Q			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	51	Potential.|CEP97 binding.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						GCTTAACATTGAGAAAAGAAA	0.343													16	66					0	0	0	0	C	19543747	C	C	19543747	3	2	4	1	0	0	0	0	1	0	0	0	3803	1291	45	2	157	2	CP110	16	19543747	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	17837404	19543747	70811006	277	1039											
SEZ6L2	26470	broad.mit.edu	37	chr16	29884920	29884920	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtcccggctgtagcaggtGagcatggctgccccctcgag	5	8	15	13	2	0	1	0	1	0	0	2	2	1	1	3	3	3	5	3	3	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:29884920G>A	uc002duq.3	-	13	2475	c.2235C>T	c.(2233-2235)CTC>CTT	p.L745L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Silent_p.L675L|SEZ6L2_uc002dur.3_Silent_p.L675L|SEZ6L2_uc002dus.3_Silent_p.L631L|SEZ6L2_uc010vec.1_Silent_p.L745L|SEZ6L2_uc010ved.1_Silent_p.L701L	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	745	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TGTAGCAGGTGAGCATGGCTG	0.687													11	65					0	0	0	0	A	29884920	A	A	29884920	2	1	4	1	0	0	0	0	0	0	0	1	14209	1277	45	2		2	SEZ6L2	16	29884920	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	10341173	29884920	60469833	278	1040											
MYLPF	29895	broad.mit.edu	37	chr16	30387201	30387201	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctccagcgtcttctccatgTtcgaccagactcagatccag	8	10	8	15	2	3	2	1	0	2	2	7	3	5	2	4	0	1	2	4	0	0	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:30387201T>C	uc002dxv.1	+	2	120	c.64T>C	c.(64-66)TTC>CTC	p.F22L		NM_013292	NP_037424	Q96A32	MLRS_HUMAN	myosin light chain, phosphorylatable, fast	22					skeletal muscle tissue development	muscle myosin complex	calcium ion binding|structural constituent of muscle				0			Colorectal(24;0.193)			CTTCTCCATGTTCGACCAGAC	0.592													11	41					0	0	0	0	C	30387201	C	C	30387201	3	2	4	1	0	0	0	0	1	0	0	0	10113	1725	60	5	70	5	MYLPF	16	30387201	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	502281	30387201	59967552	279	1041											
PRR14	78994	broad.mit.edu	37	chr16	30666893	30666894	+	Missense_Mutation	DNP	TG	AA	AA																															tcagctaaaccttacaccaaTgggactgcctcgaccaatca																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:30666893_30666894TG>AA	uc002dyy.2	+	10	1643_1644	c.1385_1386TG>AA	c.(1384-1386)ATG>AAA	p.M462K	PRR14_uc002dyz.2_Missense_Mutation_p.M307K|PRR14_uc002dza.2_Missense_Mutation_p.M462K	NM_024031	NP_076936	Q9BWN1	PRR14_HUMAN	proline rich 14	462											0			Colorectal(24;0.103)			CTTACACCAATGGGACTGCCTC	0.52													7	39					0	0	0	0	AA	30666894	AA	AA	30666893	3	1	4	1	0	0	0	0	1	0	0	0	12648	1464	51	5	1419	5	PRR14	16	30666893	Missense_Mutation	DNP	TG	TCGA-BA-4077-01B-01D-1434-08	279692	30666893	59687860	280	1042											
PHKG2	5261	broad.mit.edu	37	chr16	30767526	30767526	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgtgggaccccagggtatCtagcgccagagatccttaaa	10	9	12	10	1	1	1	0	0	1	1	2	3	2	2	4	2	1	1	4	2	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:30767526C>G	uc002dzk.1	+	7	673	c.580C>G	c.(580-582)CTA>GTA	p.L194V	PHKG2_uc002dzi.1_Missense_Mutation_p.L194V|PHKG2_uc002dzj.1_Missense_Mutation_p.L92V	NM_000294	NP_000285	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	194	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)	1			Colorectal(24;0.198)			CCCAGGGTATCTAGCGCCAGA	0.597													77	183					0	0	0	0	G	30767526	G	G	30767526	3	3	4	1	0	0	0	0	1	0	0	0	11902	912	32	2	602	2	PHKG2	16	30767526	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	100633	30767526	59587227	281	1043											
NLRC5	84166	broad.mit.edu	37	chr16	57060138	57060138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaccacgccccaggccagtCtgtggccctcctgcccaaca	7	6	9	19	1	1	1	0	1	1	0	2	1	2	1	7	2	2	0	7	2	1	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:57060138C>T	uc002ekk.1	+	6	1508	c.1283C>T	c.(1282-1284)TCT>TTT	p.S428F	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.S233F|NLRC5_uc002ekl.2_Missense_Mutation_p.S233F|NLRC5_uc002ekm.2_Missense_Mutation_p.S233F|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	428	NACHT.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CCAGGCCAGTCTGTGGCCCTC	0.637													72	111					0	0	0	0	T	57060138	T	T	57060138	3	4	4	1	0	0	0	0	1	0	0	0	10524	913	32	2	1297	2	NLRC5	16	57060138	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	26292612	57060138	33294615	282	1044											
CHST5	23563	broad.mit.edu	37	chr16	75563052	75563052	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaggcccagagttctcagtCaggcgatgcccagctgaagt	10	8	12	11	1	2	2	2	1	1	1	3	3	2	2	2	2	2	2	2	2	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:75563052C>G	uc002fei.2	-	3	2626	c.1231G>C	c.(1231-1233)GAC>CAC	p.D411H	CHST5_uc002fej.1_Missense_Mutation_p.D417H	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	411	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGTTCTCAGTCAGGCGATGCC	0.662													14	28					0	0	0	0	G	75563052	G	G	75563052	3	3	4	1	0	0	0	0	1	0	0	0	3422	826	29	2	8	2	CHST5	16	75563052	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	18502914	75563052	14791701	283	1045											
CHST5	23563	broad.mit.edu	37	chr16	75563522	75563522	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgagggtcggcctccaccCacttgccgttggtgcccagc	4	8	14	15	2	0	1	0	1	0	0	2	1	1	1	5	4	3	1	5	4	0	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr16:75563522C>G	uc002fei.2	-	3	2156	c.761G>C	c.(760-762)TGG>TCG	p.W254S	CHST5_uc002fej.1_Missense_Mutation_p.W260S	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	254	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GGCCTCCACCCACTTGCCGTT	0.731													31	68					0	0	0	0	G	75563522	G	G	75563522	3	3	4	1	0	0	0	0	1	0	0	0	3422	595	21	4	478	4	CHST5	16	75563522	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	470	75563522	14791231	284	1046											
KIAA0664	23277	broad.mit.edu	37	chr17	2600219	2600219	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcagctgcaaggcggccagcTtcataaagaggaggtacctg	11	7	13	10	1	2	1	2	0	0	1	2	2	2	2	2	4	4	4	2	4	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:2600219T>A	uc002fuy.1	-	11	1951	c.1865A>T	c.(1864-1866)AAG>ATG	p.K622M	KIAA0664_uc002fux.1_Missense_Mutation_p.K554M|KIAA0664_uc010ckc.1_5'Flank	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	622							binding			breast(2)	2						GGCGGCCAGCTTCATAAAGAG	0.627													6	8					0	0	0	0	A	2600219	A	A	2600219	3	1	4	1	0	0	0	0	1	0	0	0	8228	1609	56	5	2128	5	KIAA0664	17	2600219	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08		2600219	78594991	285	1047											
P2RX1	5023	broad.mit.edu	37	chr17	3803019	3803019	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtacgtgccagtccaggtCacagtgccagtcgatggtga	8	8	13	12	3	1	1	1	1	0	0	3	2	2	1	4	2	3	1	4	2	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:3803019C>T	uc002fww.2	-	8	1225	c.784G>A	c.(784-786)GAC>AAC	p.D262N		NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	262	Extracellular (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		CAGTCCAGGTCACAGTGCCAG	0.512													7	109					0	0	0	0	T	3803019	T	T	3803019	3	4	4	1	0	0	0	0	1	0	0	0	11393	826	29	2	435	2	P2RX1	17	3803019	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1202800	3803019	77392191	286	1048											
ZZEF1	23140	broad.mit.edu	37	chr17	4015950	4015950	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcgtcacatagccagtgAcattgctggggatgtgcaca	10	8	13	10	1	1	1	1	1	0	0	1	2	1	2	1	2	4	3	1	2	1	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:4015950A>C	uc002fxe.2	-	5	1083	c.1019T>G	c.(1018-1020)GTC>GGC	p.V340G	ZZEF1_uc002fxk.1_Missense_Mutation_p.V340G	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	340	DOC.						calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ATAGCCAGTGACATTGCTGGG	0.512													31	69					0	0	0	0	C	4015950	C	C	4015950	3	2	4	1	0	0	0	0	1	0	0	0	18322	275	10	5	8070	5	ZZEF1	17	4015950	Missense_Mutation	SNP	A	TCGA-BA-4077-01B-01D-1434-08	212931	4015950	77179260	287	1049											
ALOX15	246	broad.mit.edu	37	chr17	4542786	4542786	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcggtaacaagggaacctGacctcgtccccggctccggg	8	5	13	15	4	0	1	0	1	0	0	3	2	2	2	5	4	3	2	5	4	3	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:4542786G>A	uc002fyh.2	-	2	290	c.276C>T	c.(274-276)GTC>GTT	p.V92V	ALOX15_uc010vsd.1_Silent_p.V53V|ALOX15_uc010vse.1_Silent_p.V114V	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	92	PLAT.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	AAGGGAACCTGACCTCGTCCC	0.647													19	85					0	0	0	0	A	4542786	A	A	4542786	2	1	4	1	0	0	0	0	0	0	0	1	538	1277	45	2		2	ALOX15	17	4542786	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	526836	4542786	76652424	288	1050											
SPAG7	9552	broad.mit.edu	37	chr17	4862900	4862900	+	Missense_Mutation	SNP	C	T	T																															tctgatctcattcatagcctCttcaatggagcgtgtgtccc																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:4862900C>T	uc002gae.2	-	7	646	c.613G>A	c.(613-615)GAG>AAG	p.E205K	SPAG7_uc002gad.2_Missense_Mutation_p.E154K|SPAG7_uc002gaf.2_3'UTR	NM_004890	NP_004881	O75391	SPAG7_HUMAN	sperm associated antigen 7	205						nucleus	nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2						TTCATAGCCTCTTCAATGGAG	0.617													79	129					0	0	0	0	T	4862900	T	T	4862900	3	4	4	1	0	0	0	0	1	0	0	0	15049	922	32	2	74	2	SPAG7	17	4862900	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	320114	4862900	76332310	289	1051	3	2									
SPAG7	9552	broad.mit.edu	37	chr17	4862903	4862903	+	Missense_Mutation	SNP	C	T	T																															gatctcattcatagcctcttCaatggagcgtgtgtccctct																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:4862903C>T	uc002gae.2	-	7	643	c.610G>A	c.(610-612)GAA>AAA	p.E204K	SPAG7_uc002gad.2_Missense_Mutation_p.E153K|SPAG7_uc002gaf.2_3'UTR	NM_004890	NP_004881	O75391	SPAG7_HUMAN	sperm associated antigen 7	204						nucleus	nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2						ATAGCCTCTTCAATGGAGCGT	0.617													75	129					0	0	0	0	T	4862903	T	T	4862903	3	4	4	1	0	0	0	0	1	0	0	0	15049	835	29	2	77	2	SPAG7	17	4862903	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	3	4862903	76332307	290	1052	3	2									
SPAG7	9552	broad.mit.edu	37	chr17	4863614	4863614	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacttccaccacatcatgtCtgggatgggatggcagaggg	9	8	13	11	0	2	1	1	0	1	1	3	3	3	3	3	4	0	1	3	4	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:4863614C>A	uc002gae.2	-	4	276	c.243_splice	c.e4-1	p.L81_splice	SPAG7_uc002gad.2_Splice_Site_p.L30_splice|SPAG7_uc002gaf.2_Splice_Site_p.L81_splice	NM_004890	NP_004881	O75391	SPAG7_HUMAN	sperm associated antigen 7							nucleus	nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2						CACATCATGTCTGGGATGGGA	0.567													31	46					2.52449e-32	2.81429e-32	1	0	A	4863614	A	A	4863614	5	1	4	1	0	0	0	0	0	0	1	0	15049	927	32	2	457	2	SPAG7	17	4863614	Splice_Site	SNP	C	TCGA-BA-4077-01B-01D-1434-08	711	4863614	76331596	291	1053											
POLR2A	5430	broad.mit.edu	37	chr17	7417029	7417029	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cacgatacacaccacagtctCcaacctataccccaagctca	14	6	3	18	1	2	0	1	0	1	0	3	1	2	0	5	0	4	1	5	0	5	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:7417029C>G	uc002ghf.3	+	29	5680	c.5446C>G	c.(5446-5448)CCA>GCA	p.P1816A		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1816	32.|52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				ACCACAGTCTCCAACCTATAC	0.443													146	279					0	0	0	0	G	7417029	G	G	7417029	3	3	4	1	0	0	0	0	1	0	0	0	12269	855	30	2	5560	2	POLR2A	17	7417029	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2553415	7417029	73778181	292	1054											
CHD3	1107	broad.mit.edu	37	chr17	7812049	7812049	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggcaggacatccagaatGatgctcaatttgccattatc	11	11	10	9	0	1	2	1	1	0	1	3	3	2	3	2	3	2	2	2	3	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:7812049G>T	uc002gje.2	+	36	5446	c.5296G>T	c.(5296-5298)GAT>TAT	p.D1766Y	CHD3_uc002gjd.2_Missense_Mutation_p.D1825Y|CHD3_uc002gjf.2_Missense_Mutation_p.D1732Y|CHD3_uc002gjh.2_Missense_Mutation_p.D343Y|CHD3_uc002gjj.2_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1766	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				CATCCAGAATGATGCTCAATT	0.443													26	218					4.72057e-08	4.94698e-08	1	0	T	7812049	T	T	7812049	3	4	4	1	0	0	0	0	1	0	0	0	3341	1290	45	2	5719	2	CHD3	17	7812049	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	395020	7812049	73383161	293	1055											
DNAH9	1770	broad.mit.edu	37	chr17	11835359	11835359	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagatgtgttctcgggagaCggagtttaagagcatcctct	9	11	14	7	2	2	3	0	0	2	3	4	6	3	4	1	3	1	3	1	3	1	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:11835359C>T	uc002gne.2	+	64	12202	c.12134C>T	c.(12133-12135)ACG>ATG	p.T4045M	DNAH9_uc010coo.2_Missense_Mutation_p.T3263M|DNAH9_uc002gnf.2_Missense_Mutation_p.T357M	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	4045	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TCTCGGGAGACGGAGTTTAAG	0.498													10	475					0	0	0	0	T	11835359	T	T	11835359	3	4	4	1	0	0	0	0	1	0	0	0	4630	536	19	1	12388	1	DNAH9	17	11835359	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	4023310	11835359	69359851	294	1056											
FLOT2	2319	broad.mit.edu	37	chr17	27209040	27209040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcataggccaactgggcctCagctgtctgtggcaagaggg	8	8	14	11	0	3	1	2	0	1	1	3	1	3	1	2	4	2	2	2	4	3	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:27209040C>T	uc002hdc.2	-	8	829	c.706G>A	c.(706-708)GAG>AAG	p.E236K		NM_004475	NP_004466	Q14254	FLOT2_HUMAN	flotillin 2	236					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction					0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			AACTGGGCCTCAGCTGTCTGT	0.572													18	54					0	0	0	0	T	27209040	T	T	27209040	3	4	4	1	0	0	0	0	1	0	0	0	5969	835	29	2	596	2	FLOT2	17	27209040	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	15373681	27209040	53986170	295	1057											
RFFL	117584	broad.mit.edu	37	chr17	33348692	33348692	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcatgagctcctctcgctGaaaggctgtagctcgaaacc	9	10	9	13	2	2	2	1	2	1	0	5	3	3	2	2	1	3	5	2	1	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:33348692G>A	uc002hin.1	-	3	462	c.289C>T	c.(289-291)CAG>TAG	p.Q97*	RFFL_uc002hiq.2_Intron|RFFL_uc002him.1_Nonsense_Mutation_p.Q97*|RFFL_uc010cti.1_Nonsense_Mutation_p.Q103*|RFFL_uc002hip.1_Nonsense_Mutation_p.Q97*|RFFL_uc002hio.1_Nonsense_Mutation_p.Q97*	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	97					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TCCTCTCGCTGAAAGGCTGTA	0.512													16	128					0	0	0	0	A	33348692	A	A	33348692	4	1	4	1	0	0	0	0	0	1	0	0	13315	1299	45	2	822	2	RFFL	17	33348692	Nonsense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	6139652	33348692	47846518	296	1058											
NLE1	54475	broad.mit.edu	37	chr17	33469078	33469078	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcgaacggggaacccagcaGctgcccgccctcatcctgga	8	5	12	16	3	1	0	1	0	0	0	3	3	2	2	4	3	5	2	4	3	2	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:33469078G>A	uc002hiy.1	-	2	110	c.82C>T	c.(82-84)CTG>TTG	p.L28L	NLE1_uc010ctn.1_5'UTR|NLE1_uc002hiz.1_5'UTR	NM_018096	NP_060566	Q9NVX2	NLE1_HUMAN	Notchless gene homolog isoform a	28						nucleolus				breast(3)|ovary(1)	4		Ovarian(249;0.17)				GAACCCAGCAGCTGCCCGCCC	0.687													7	26					0	0	0	0	A	33469078	A	A	33469078	2	1	4	1	0	0	0	0	0	0	0	1	10514	962	34	4		4	NLE1	17	33469078	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	120386	33469078	47726132	297	1059											
GPR179	440435	broad.mit.edu	37	chr17	36486529	36486529	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgggactggtgccagggCaggggctggggttggagcta	6	8	20	7	0	0	0	0	0	0	0	0	2	0	2	1	8	3	4	1	8	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:36486529C>A	uc002hpz.2	-	11	2944	c.2923G>T	c.(2923-2925)GCC>TCC	p.A975S		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	975	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				ggtgccagggcaggggctggg	0.453													22	43					3.10358e-05	3.19874e-05	1	0	A	36486529	A	A	36486529	3	1	4	1	0	0	0	0	1	0	0	0	6712	710	25	4	4184	4	GPR179	17	36486529	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	3017451	36486529	44708681	298	1060											
ERBB2	2064	broad.mit.edu	37	chr17	37880180	37880180	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagggcatctggatccctGatggggagaatgtgaaaatt	11	9	13	8	0	1	3	0	2	1	1	2	5	2	4	2	4	0	1	2	4	3	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:37880180G>C	uc002hso.2	+	19	2462	c.2224G>C	c.(2224-2226)GAT>CAT	p.D742H	ERBB2_uc002hsm.2_Missense_Mutation_p.D712H|ERBB2_uc010cwa.2_Missense_Mutation_p.D727H|ERBB2_uc002hsp.2_Missense_Mutation_p.D545H|ERBB2_uc010cwb.2_Missense_Mutation_p.D742H|ERBB2_uc010wek.1_Missense_Mutation_p.D466H	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	742	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CTGGATCCCTGATGGGGAGAA	0.502		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			4	67					0	0	0	0	C	37880180	C	C	37880180	3	2	4	1	0	0	0	0	1	0	0	0	5230	1290	45	2	2298	2	ERBB2	17	37880180	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1393651	37880180	43315030	299	1061											
EIF1	10209	broad.mit.edu	37	chr17	39847033	39847033	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgcccttttgtcttttcaGattggactggctaaggacga	7	16	10	8	1	2	1	1	0	1	1	2	4	2	3	1	3	1	1	1	3	1	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:39847033G>A	uc002hxj.2	+	4	462	c.298_splice	c.e4-1	p.I100_splice	JUP_uc010wfs.1_Intron|EIF1_uc002hxk.2_Splice_Site	NM_005801	NP_005792	P41567	EIF1_HUMAN	eukaryotic translation initiation factor 1						regulation of translational initiation|response to stress	cytoplasm	translation initiation factor activity				0		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TGTCTTTTCAGATTGGACTGG	0.443													37	120					0	0	0	0	A	39847033	A	A	39847033	5	1	4	1	0	0	0	0	0	0	1	0	5012	956	33	2	311	2	EIF1	17	39847033	Splice_Site	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1966853	39847033	41348177	300	1062											
HAP1	9001	broad.mit.edu	37	chr17	39881154	39881154	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggctgatgtcaccacgttCatccgcgttgcctcatccag	7	10	10	14	3	3	1	3	1	0	0	5	1	5	1	4	1	1	3	4	1	0	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:39881154C>T	uc002hxm.1	-	12	1827	c.1815G>A	c.(1813-1815)ATG>ATA	p.M605I	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Missense_Mutation_p.M553I|HAP1_uc002hxo.1_Missense_Mutation_p.M536I|HAP1_uc002hxp.1_Missense_Mutation_p.M528I	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	605					brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TCACCACGTTCATCCGCGTTG	0.607													184	319					0	0	0	0	T	39881154	T	T	39881154	3	4	4	1	0	0	0	0	1	0	0	0	6992	826	29	2	204	2	HAP1	17	39881154	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	34121	39881154	41314056	301	1063											
HAP1	9001	broad.mit.edu	37	chr17	39881246	39881246	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcttccatcaccccttcctCagccggcaccttcttggcag	5	11	6	19	1	4	0	2	0	2	0	6	0	6	0	6	2	1	2	6	2	0	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:39881246C>G	uc002hxm.1	-	12	1735	c.1723G>C	c.(1723-1725)GAG>CAG	p.E575Q	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Missense_Mutation_p.E523Q|HAP1_uc002hxo.1_Missense_Mutation_p.E506Q|HAP1_uc002hxp.1_Missense_Mutation_p.E498Q	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	575	Glu-rich.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			ACCCCTTCCTCAGCCGGCACC	0.627													187	410					0	0	0	0	G	39881246	G	G	39881246	3	3	4	1	0	0	0	0	1	0	0	0	6992	835	29	2	296	2	HAP1	17	39881246	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	92	39881246	41313964	302	1064											
ETV4	2118	broad.mit.edu	37	chr17	41622708	41622708	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgggccgatcagcgcttCgcgcaagctcccatttccgg	6	7	12	16	6	1	0	1	0	0	0	4	1	3	0	3	2	3	3	3	2	1	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:41622708C>A	uc002idw.2	-	3	216	c.88G>T	c.(88-90)GAA>TAA	p.E30*	ETV4_uc010wih.1_Nonsense_Mutation_p.E30*|ETV4_uc010czh.2_Nonsense_Mutation_p.E30*|ETV4_uc010wii.1_5'UTR|ETV4_uc002idx.2_Nonsense_Mutation_p.E30*|ETV4_uc010wij.1_5'UTR|ETV4_uc002idy.1_5'UTR	NM_001986	NP_001977	P43268	ETV4_HUMAN	ets variant gene 4 (E1A enhancer binding	30					positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/ETV4(6)	bone(4)|soft_tissue(2)|ovary(1)	7		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)		ATCAGCGCTTCGCGCAAGCTC	0.647			T	EWSR1|TMPRSS2|DDX5|KLK2|CANT1	Ewing sarcoma|Prostate carcinoma								7	19					0.00198382	0.00203028	1	0	A	41622708	A	A	41622708	4	1	4	1	0	0	0	0	0	1	0	0	5305	893	31	3	1410	3	ETV4	17	41622708	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1741462	41622708	39572502	303	1065											
CCDC43	124808	broad.mit.edu	37	chr17	42757999	42757999	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagcacctgaatcatccttCtcatctgcttcagtaagtga	10	13	7	11	0	4	2	3	2	2	0	6	2	5	2	2	0	2	4	2	0	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:42757999C>G	uc002ihc.2	-	4	485	c.441G>C	c.(439-441)GAG>GAC	p.E147D	CCDC43_uc010czw.1_Intron	NM_144609	NP_653210	Q96MW1	CCD43_HUMAN	coiled-coil domain containing 43 isoform 1	147											0		Prostate(33;0.0322)				AATCATCCTTCTCATCTGCTT	0.408													26	165					0	0	0	0	G	42757999	G	G	42757999	3	3	4	1	0	0	0	0	1	0	0	0	2828	912	32	2	241	2	CCDC43	17	42757999	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1135291	42757999	38437211	304	1066											
INTS2	57508	broad.mit.edu	37	chr17	59968949	59968949	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggcttctggattagatttCgacgcaggagtaagtataga	11	12	13	5	2	1	2	0	0	1	2	2	5	1	4	0	3	0	4	0	3	4	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:59968949C>T	uc002izn.2	-	14	1900	c.1824G>A	c.(1822-1824)TCG>TCA	p.S608S	INTS2_uc002izm.2_Silent_p.S600S	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	608					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						GATTAGATTTCGACGCAGGAG	0.373													66	114					0	0	0	0	T	59968949	T	T	59968949	2	4	4	1	0	0	0	0	0	0	0	1	7817	871	31	1		1	INTS2	17	59968949	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	17210950	59968949	21226261	305	1067											
MED13	9969	broad.mit.edu	37	chr17	60060429	60060429	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccaaaagaagtatgagtttGaggtgtataagcagtgccat	14	10	11	6	0	0	3	0	2	0	1	0	3	0	3	2	1	2	4	2	1	6	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:60060429G>C	uc002izo.2	-	16	3012	c.2935C>G	c.(2935-2937)CAA>GAA	p.Q979E		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	979					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GTATGAGTTTGAGGTGTATAA	0.418													9	62					0	0	0	0	C	60060429	C	C	60060429	3	2	4	1	0	0	0	0	1	0	0	0	9483	1299	45	2	3649	2	MED13	17	60060429	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	91480	60060429	21134781	306	1068											
MRC2	9902	broad.mit.edu	37	chr17	60758228	60758228	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagcaccactccacgtgggcGcaggcgcagcgcatctgcac	8	4	13	16	4	1	0	0	0	1	0	2	1	2	0	2	2	3	5	2	2	0	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:60758228G>A	uc002jad.2	+	17	2943	c.2541G>A	c.(2539-2541)GCG>GCA	p.A847A	MRC2_uc002jae.2_5'UTR|MRC2_uc002jaf.2_5'Flank	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	847	Extracellular (Potential).|C-type lectin 5.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCACGTGGGCGCAGGCGCAGC	0.667													3	46					0	0	0	0	A	60758228	A	A	60758228	2	1	4	1	0	0	0	0	0	0	0	1	9811	1074	38	1		1	MRC2	17	60758228	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	697799	60758228	20436982	307	1069											
MARCH10	162333	broad.mit.edu	37	chr17	60814396	60814396	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgctgttcaatgacaaaatgGaataaaagtcttcatctcgg	14	12	8	7	1	4	1	2	1	2	0	5	2	4	2	0	2	1	2	0	2	6	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:60814396G>C	uc010ddr.2	-	6	1071	c.833C>G	c.(832-834)TCC>TGC	p.S278C	MARCH10_uc002jag.3_Missense_Mutation_p.S278C|MARCH10_uc010dds.2_Missense_Mutation_p.S316C|MARCH10_uc002jah.2_Missense_Mutation_p.S277C|uc002jaj.1_RNA|uc002jak.2_RNA	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	278							ligase activity|zinc ion binding				0						TGACAAAATGGAATAAAAGTC	0.488													101	376					0	0	0	0	C	60814396	C	C	60814396	3	2	4	1	0	0	0	0	1	0	0	0	9352	1174	41	2	1617	2	MARCH10	17	60814396	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	56168	60814396	20380814	308	1070											
RECQL5	9400	broad.mit.edu	37	chr17	73658604	73658604	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccttaaggcagaagtccttCaggttcccatagggatcaga	11	9	11	10	0	2	2	2	0	0	2	4	3	4	3	3	3	0	2	3	3	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr17:73658604C>T	uc010dgl.2	-	4	882	c.726G>A	c.(724-726)CTG>CTA	p.L242L	RECQL5_uc010dgk.2_Silent_p.L215L|RECQL5_uc002jpb.1_Silent_p.L242L|RECQL5_uc002joz.3_Silent_p.L242L|RECQL5_uc002jpa.3_Silent_p.L242L	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	242	Helicase C-terminal.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			AGAAGTCCTTCAGGTTCCCAT	0.512								Other_identified_genes_with_known_or_suspected_DNA_repair_function					223	410					0	0	0	0	T	73658604	T	T	73658604	2	4	4	1	0	0	0	0	0	0	0	1	13268	813	29	2		2	RECQL5	17	73658604	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	12844208	73658604	7536606	309	1071											
CIDEA	1149	broad.mit.edu	37	chr18	12264384	12264384	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccgtggtggacacagaaGagttctttcagaccttggga	10	9	13	9	1	2	3	1	0	1	3	2	5	2	5	2	3	0	2	2	3	1	3	rs139948292		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr18:12264384G>T	uc002kqt.3	+	3	327	c.262G>T	c.(262-264)GAG>TAG	p.E88*	CIDEA_uc002kqu.3_Nonsense_Mutation_p.E122*|CIDEA_uc010dlc.2_RNA	NM_001279	NP_001270	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a isoform	88	CIDE-N.				DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			ovary(1)|central_nervous_system(1)	2						GGACACAGAAGAGTTCTTTCA	0.512													33	64					1.61788e-16	1.75003e-16	1	0	T	12264384	T	T	12264384	4	4	4	1	0	0	0	0	0	1	0	0	3440	943	33	2	416	2	CIDEA	18	12264384	Nonsense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08		12264384	65812864	310	1072											
CTAGE1	64693	broad.mit.edu	37	chr18	19996658	19996658	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctaaccggcatttttcctCtactattaatttcctgtaga	9	17	4	11	1	2	1	0	0	2	1	4	1	4	1	3	1	2	2	3	1	5	8			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr18:19996658C>T	uc002ktv.1	-	1	1221	c.1117G>A	c.(1117-1119)GAG>AAG	p.E373K		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	373	Potential.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					CATTTTTCCTCTACTATTAAT	0.368													17	109					0	0	0	0	T	19996658	T	T	19996658	3	4	4	1	0	0	0	0	1	0	0	0	4009	922	32	2	1124	2	CTAGE1	18	19996658	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	7732274	19996658	58080590	311	1073											
C18orf21	83608	broad.mit.edu	37	chr18	33554876	33554876	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagatgataagagcacttttGaagaaacgtgtccatactgt	14	12	9	6	1	0	5	0	2	0	3	1	5	1	5	1	0	3	1	1	0	5	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr18:33554876G>C	uc002kzc.2	+	3	222	c.118G>C	c.(118-120)GAA>CAA	p.E40Q	C18orf21_uc002kzd.2_5'UTR	NM_031446	NP_113634	Q32NC0	CR021_HUMAN	chromosome 18 open reading frame 21	40											0						GAGCACTTTTGAAGAAACGTG	0.353													25	118					0	0	0	0	C	33554876	C	C	33554876	3	2	4	1	0	0	0	0	1	0	0	0	1906	1291	45	2	128	2	C18orf21	18	33554876	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	13558218	33554876	44522372	312	1074											
SERPINB4	6318	broad.mit.edu	37	chr18	61328411	61328411	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tctgaactgttggaacaggtCgaacatgaacttggtgttgg	10	12	13	6	1	1	2	0	2	1	0	2	4	1	3	0	4	4	2	0	4	4	3	rs148776258	byFrequency	TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr18:61328411C>G	uc002ljg.2	-	1	66	c.40G>C	c.(40-42)GAC>CAC	p.D14H	SERPINB3_uc002lji.2_Missense_Mutation_p.D14H|SERPINB3_uc010dqa.2_Missense_Mutation_p.D14H|SERPINB3_uc010dqb.2_Missense_Mutation_p.D14H|SERPINB3_uc010dqc.2_Missense_Mutation_p.D14H			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	14					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						TGGAACAGGTCGAACATGAAC	0.428													87	226					0	0	0	0	G	61328411	G	G	61328411	3	3	4	1	0	0	0	0	1	0	0	0	14168	884	31	3		3	SERPINB4	18	61328411	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	27773535	61328411	16748837	313	1075											
GNA15	2769	broad.mit.edu	37	chr19	3148635	3148635	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatcaagcagatgcggatCatccacggcgccggctactc	9	8	10	14	4	3	1	3	0	0	1	5	2	4	2	2	3	3	2	2	3	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:3148635C>T	uc002lxf.2	+	2	450	c.192C>T	c.(190-192)ATC>ATT	p.I64I	GNA15_uc010xhf.1_Silent_p.I64I	NM_002068	NP_002059	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein),	64					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		AGATGCGGATCATCCACGGCG	0.657													4	8					0	0	0	0	T	3148635	T	T	3148635	2	4	4	1	0	0	0	0	0	0	0	1	6540	816	29	2		2	GNA15	19	3148635	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08		3148635	55980348	314	1076											
PTPRS	5802	broad.mit.edu	37	chr19	5274263	5274264	+	Missense_Mutation	DNP	GC	AA	AA																															cttgttccaggtcactcgtgGcttggggtcacccgtggcct																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:5274263_5274264GC>AA	uc002mbv.2	-	3	417_418	c.183_184GC>TT	c.(181-186)AAGCCA>AATTCA	p.61_62KP>NS	PTPRS_uc002mbu.1_Missense_Mutation_p.61_62KP>NS|PTPRS_uc010xin.1_Missense_Mutation_p.61_62KP>NS|PTPRS_uc002mbw.2_Missense_Mutation_p.61_62KP>NS|PTPRS_uc002mbx.2_Missense_Mutation_p.61_62KP>NS|PTPRS_uc002mby.2_Missense_Mutation_p.61_62KP>NS|PTPRS_uc002mbz.1_Missense_Mutation_p.61_62KP>NS	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	61_62	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GTCACTCGTGGCTTGGGGTCAC	0.604													20	50					0	0	0	0	AA	5274264	AA	AA	5274263	3	1	4	1	0	0	0	0	1	0	0	0	12876	1203	42	4	5806	4	PTPRS	19	5274263	Missense_Mutation	DNP	GC	TCGA-BA-4077-01B-01D-1434-08	2125628	5274263	53854720	315	1077											
CAPS	828	broad.mit.edu	37	chr19	5914740	5914740	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatctggaggagttccttCgggcgctgcgggtgagcccc	4	9	17	11	3	1	1	0	1	1	0	3	4	2	4	3	5	2	2	3	5	0	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:5914740C>A	uc002mdt.2	+	3	400	c.250C>A	c.(250-252)CGG>AGG	p.R84R	CAPS_uc002mdu.2_Silent_p.R84R	NM_004058	NP_004049	Q13938	CAYP1_HUMAN	calcyphosine isoform a	84	EF-hand 2.				intracellular signal transduction	cytoplasm	calcium ion binding				0						GGAGTTCCTTCGGGCGCTGCG	0.667													30	109					2.61193e-14	2.79758e-14	1	0	A	5914740	A	A	5914740	2	1	4	1	0	0	0	0	0	0	0	1	2649	875	31	3		3	CAPS	19	5914740	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	640477	5914740	53214243	316	1078											
MYO1F	4542	broad.mit.edu	37	chr19	8601428	8601428	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcggtaggcgaagccggctCtgcgcaccctgatgttctcc	5	8	14	14	4	2	1	0	1	2	0	3	2	2	1	3	4	2	4	3	4	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:8601428C>G	uc002mkg.2	-	18	1967	c.1853G>C	c.(1852-1854)AGA>ACA	p.R618T		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	618	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GAAGCCGGCTCTGCGCACCCT	0.652													39	81					0	0	0	0	G	8601428	G	G	8601428	3	3	4	1	0	0	0	0	1	0	0	0	10126	913	32	2	1487	2	MYO1F	19	8601428	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2686688	8601428	50527555	317	1079											
ZNF559	84527	broad.mit.edu	37	chr19	9452472	9452472	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaggagaacttactttagAaagaaaacctgtgagtgtaa	17	9	9	6	0	0	4	0	1	0	3	0	5	0	4	1	1	3	1	1	1	7	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:9452472A>G	uc002mlg.2	+	7	992	c.345A>G	c.(343-345)AGA>AGG	p.R115R	ZNF559_uc002mlf.2_5'UTR|ZNF559_uc010dwl.1_5'UTR|ZNF559_uc010xkn.1_Silent_p.R107R|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Silent_p.R179R|ZNF559_uc010dwk.1_5'UTR|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTTACTTTAGAAAGAAAACCT	0.373													10	82					0	0	0	0	G	9452472	G	G	9452472	2	3	4	1	0	0	0	0	0	0	0	1	18057	243	9	5		5	ZNF559	19	9452472	Silent	SNP	A	TCGA-BA-4077-01B-01D-1434-08	851044	9452472	49676511	318	1080											
ICAM1	3383	broad.mit.edu	37	chr19	10395132	10395132	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggtctcagaagggaccGaggtgacagtgaagtgtgag	12	6	17	6	1	1	5	1	3	1	2	2	7	1	6	1	3	0	0	1	3	2	0	rs143008699		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:10395132G>T	uc002mnq.2	+	5	1298	c.979G>T	c.(979-981)GAG>TAG	p.E327*	ICAM1_uc010xle.1_Nonsense_Mutation_p.E105*|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	327	Ig-like C2-type 4.|Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	AGAAGGGACCGAGGTGACAGT	0.642													44	91					1.41504e-22	1.56947e-22	1	0	T	10395132	T	T	10395132	4	4	4	1	0	0	0	0	0	1	0	0	7518	1059	37	3	997	3	ICAM1	19	10395132	Nonsense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	942660	10395132	48733851	319	1081											
LDLR	3949	broad.mit.edu	37	chr19	11231182	11231182	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgctgctggccagggacatGaggagctgcctcacaggtgt	8	8	15	10	0	1	1	1	1	0	0	1	3	1	3	2	4	4	3	2	4	0	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:11231182G>A	uc002mqk.3	+	14	2292	c.2124G>A	c.(2122-2124)ATG>ATA	p.M708I	LDLR_uc010xlk.1_Missense_Mutation_p.M708I|LDLR_uc010xll.1_Missense_Mutation_p.M667I|LDLR_uc010xlm.1_Missense_Mutation_p.M561I|LDLR_uc010xln.1_Intron|LDLR_uc010xlo.1_Missense_Mutation_p.M540I	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	708	EGF-like 3.|Extracellular (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CCAGGGACATGAGGAGCTGCC	0.527													12	67					0	0	0	0	A	11231182	A	A	11231182	3	1	4	1	0	0	0	0	1	0	0	0	8744	1290	45	2	2178	2	LDLR	19	11231182	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	836050	11231182	47897801	320	1082											
USE1	55850	broad.mit.edu	37	chr19	17330509	17330509	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agacggagtcagagcgtctgGagcagcacacgcagaagtca	13	4	14	10	3	3	3	2	0	1	3	3	5	3	5	0	2	3	3	0	2	1	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:17330509G>A	uc002nfo.2	+	8	727	c.667G>A	c.(667-669)GAG>AAG	p.E223K	USE1_uc010eal.1_3'UTR	NM_018467	NP_060937	Q9NZ43	USE1_HUMAN	unconventional SNARE in the ER 1 homolog	223	Cytoplasmic (Potential).|Potential.				lysosomal transport|protein catabolic process|protein transport|secretion by cell|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	protein binding				0						AGAGCGTCTGGAGCAGCACAC	0.522													32	74					0	0	0	0	A	17330509	A	A	17330509	3	1	4	1	0	0	0	0	1	0	0	0	17099	1175	41	2	697	2	USE1	19	17330509	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	6099327	17330509	41798474	321	1083											
PLVAP	83483	broad.mit.edu	37	chr19	17476503	17476503	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgagcccaggggatggtaGaggttgtaacccaggttgtc	8	9	15	9	1	0	1	0	0	0	1	2	3	1	2	3	5	2	4	3	5	2	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:17476503G>C	uc002ngk.1	-	3	821	c.771C>G	c.(769-771)CTC>CTG	p.L257L		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	257	Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						GGGGATGGTAGAGGTTGTAAC	0.607													5	130					0	0	0	0	C	17476503	C	C	17476503	2	2	4	1	0	0	0	0	0	0	0	1	12171	929	33	2		2	PLVAP	19	17476503	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	145994	17476503	41652480	322	1084											
CILP2	148113	broad.mit.edu	37	chr19	19656361	19656361	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgggatgctgttcgaccagCggcaggtggacaggacgctg	7	6	18	10	4	0	0	0	0	0	0	1	4	0	3	1	5	2	4	1	5	0	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:19656361C>A	uc002nmv.3	+	8	3092	c.3007C>A	c.(3007-3009)CGG>AGG	p.R1003R	CILP2_uc002nmw.3_Silent_p.R1009R	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1003						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GTTCGACCAGCGGCAGGTGGA	0.682													16	15					5.35267e-07	5.58261e-07	1	0	A	19656361	A	A	19656361	2	1	4	1	0	0	0	0	0	0	0	1	3445	759	27	3		3	CILP2	19	19656361	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2179858	19656361	39472622	323	1085											
ZNF486	90649	broad.mit.edu	37	chr19	20308540	20308540	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcgatccttagtaaacatGagaagattcatacgggagag	14	9	10	8	2	1	3	1	1	0	3	3	6	2	3	2	1	2	1	2	1	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:20308540G>C	uc002nou.2	+	4	1078	c.1021G>C	c.(1021-1023)GAG>CAG	p.E341Q		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	341	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAGTAAACATGAGAAGATTCA	0.398													23	53					0	0	0	0	C	20308540	C	C	20308540	3	2	4	1	0	0	0	0	1	0	0	0	18006	1291	45	2	1035	2	ZNF486	19	20308540	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	652179	20308540	38820443	324	1086											
NUDT19	390916	broad.mit.edu	37	chr19	33183421	33183421	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgcggctgtgcgcccacctCgactgcacacccgacatctg	6	7	10	18	4	1	0	0	0	1	0	2	2	1	0	3	1	3	2	3	1	0	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:33183421C>G	uc010edf.2	+	1	555	c.555C>G	c.(553-555)CTC>CTG	p.L185L		NM_001105570	NP_001099040	A8MXV4	NUD19_HUMAN	nudix (nucleoside diphosphate linked moiety	185	Nudix hydrolase.					mitochondrion|peroxisome	hydrolase activity|metal ion binding				0	Esophageal squamous(110;0.137)					GCGCCCACCTCGACTGCACAC	0.721													5	8					0	0	0	0	G	33183421	G	G	33183421	2	3	4	1	0	0	0	0	0	0	0	1	10790	871	31	3		3	NUDT19	19	33183421	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	12874881	33183421	25945562	325	1087											
FFAR2	2867	broad.mit.edu	37	chr19	35941408	35941408	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccgtggtgttcagttcactCaacgccagtctggaccccct	6	10	10	15	2	4	0	3	0	1	0	4	1	4	1	4	2	1	2	4	2	1	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:35941408C>G	uc002nzg.2	+	2	872	c.792C>G	c.(790-792)CTC>CTG	p.L264L	FFAR2_uc010eea.2_Silent_p.L264L	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	264	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TCAGTTCACTCAACGCCAGTC	0.582													53	196					0	0	0	0	G	35941408	G	G	35941408	2	3	4	1	0	0	0	0	0	0	0	1	5860	813	29	2		2	FFAR2	19	35941408	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2757987	35941408	23187575	326	1088											
ARHGAP33	115703	broad.mit.edu	37	chr19	36278704	36278704	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgggcccccctgcaccactCgacaggggagagaacctgta	9	5	12	15	1	0	1	0	0	0	1	1	4	0	2	5	3	2	2	5	3	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:36278704C>T	uc002obs.1	+	21	2839	c.2754C>T	c.(2752-2754)CTC>CTT	p.L918L	ARHGAP33_uc002obt.1_Silent_p.L915L|ARHGAP33_uc010eel.2_Intron|ARHGAP33_uc002obv.1_Silent_p.L667L	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	1079					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						CTGCACCACTCGACAGGGGAG	0.672													39	100					0	0	0	0	T	36278704	T	T	36278704	2	4	4	1	0	0	0	0	0	0	0	1	882	871	31	1		1	ARHGAP33	19	36278704	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	337296	36278704	22850279	327	1089											
FCGBP	8857	broad.mit.edu	37	chr19	40357470	40357470	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gttttgccatggcagatctgGacttcggcaactacacggta	9	11	11	10	2	1	1	0	0	1	1	2	2	1	2	1	4	3	4	1	4	3	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:40357470G>C	uc002omp.3	-	34	15851	c.15843C>G	c.(15841-15843)GTC>GTG	p.V5281V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5281	VWFD 13.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGCAGATCTGGACTTCGGCAA	0.572													10	76					0	0	0	0	C	40357470	C	C	40357470	2	2	4	1	0	0	0	0	0	0	0	1	5810	1161	41	2		2	FCGBP	19	40357470	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	4078766	40357470	18771513	328	1090											
ZNF780A	284323	broad.mit.edu	37	chr19	40581109	40581109	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttacattcatatggttttaTaccagcatgaatactctgat	12	16	5	8	0	2	2	1	2	1	0	2	2	2	2	1	1	4	2	1	1	6	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:40581109T>C	uc002omy.2	-	6	1465	c.1240A>G	c.(1240-1242)ATA>GTA	p.I414V	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.I414V|ZNF780A_uc010xvh.1_Missense_Mutation_p.I415V	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TATGGTTTTATACCAGCATGA	0.383													6	418					0	0	0	0	C	40581109	C	C	40581109	3	2	4	1	0	0	0	0	1	0	0	0	18219	1406	49	5	816	5	ZNF780A	19	40581109	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	223639	40581109	18547874	329	1091											
IRGQ	126298	broad.mit.edu	37	chr19	44097009	44097009	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctctcgcccttgggattCtccatcttgccttctcccag	5	13	7	16	1	4	0	0	0	4	0	7	1	4	1	4	1	2	1	4	1	1	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:44097009C>G	uc002oww.2	-	2	1159	c.1041G>C	c.(1039-1041)GAG>GAC	p.E347D	IRGQ_uc010eiv.2_Missense_Mutation_p.E347D	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	347							protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				CCTTGGGATTCTCCATCTTGC	0.587													8	359					0	0	0	0	G	44097009	G	G	44097009	3	3	4	1	0	0	0	0	1	0	0	0	7878	912	32	2	834	2	IRGQ	19	44097009	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	3515900	44097009	15031974	330	1092											
ZNF331	55422	broad.mit.edu	37	chr19	54080952	54080952	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgagagaatccacacaggcGaaaccccgtataaatgtaag	17	5	9	10	3	0	1	0	0	0	1	1	4	1	1	3	1	1	2	3	1	6	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:54080952G>A	uc002qbx.1	+	7	2572	c.1138G>A	c.(1138-1140)GAA>AAA	p.E380K	ZNF331_uc002qby.1_Missense_Mutation_p.E380K|ZNF331_uc002qbz.1_Missense_Mutation_p.E380K|ZNF331_uc002qca.1_Missense_Mutation_p.E380K|ZNF331_uc010eqr.1_Missense_Mutation_p.E380K|ZNF331_uc002qcb.1_Missense_Mutation_p.E380K|ZNF331_uc002qcc.1_Missense_Mutation_p.E380K|ZNF331_uc002qcd.1_Missense_Mutation_p.E380K	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		CCACACAGGCGAAACCCCGTA	0.498			T	?	follicular thyroid adenoma								31	56					0	0	0	0	A	54080952	A	A	54080952	3	1	4	1	0	0	0	0	1	0	0	0	17916	1059	37	1	1148	1	ZNF331	19	54080952	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	9983943	54080952	5048031	331	1093											
LILRB5	10990	broad.mit.edu	37	chr19	54758747	54758747	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctataagactggtactttGactttagacacagcggggga	11	11	12	7	1	1	3	0	1	1	2	1	4	1	4	0	3	2	1	0	3	4	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:54758747G>A	uc002qex.2	-	6	1217	c.1106C>T	c.(1105-1107)TCA>TTA	p.S369L	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.S360L|LILRB5_uc002qey.2_Missense_Mutation_p.S369L|LILRB5_uc002qez.2_Missense_Mutation_p.S269L|LILRB5_uc002qfa.1_Missense_Mutation_p.S259L|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	369	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGGTACTTTGACTTTAGACA	0.527													7	84					0	0	0	0	A	54758747	A	A	54758747	3	1	4	1	0	0	0	0	1	0	0	0	8835	1294	45	2	701	2	LILRB5	19	54758747	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	677795	54758747	4370236	332	1094											
ZNF628	89887	broad.mit.edu	37	chr19	55994342	55994342	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacacgggcgagcggcccttCcgctgcccgctctgccccaa	5	5	11	20	5	1	0	0	0	1	0	2	1	2	0	5	2	3	2	5	2	1	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:55994342C>A	uc002qld.2	+	3	2335	c.1770C>A	c.(1768-1770)TTC>TTA	p.F590L	NAT14_uc002qle.1_5'Flank	NM_033113	NP_149104	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	590	C2H2-type 15.					nucleus	DNA binding|zinc ion binding				0	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		AGCGGCCCTTCCGCTGCCCGC	0.711													4	29					0.00909568	0.0092653	1	0	A	55994342	A	A	55994342	3	1	4	1	0	0	0	0	1	0	0	0	18119	854	30	2	1772	2	ZNF628	19	55994342	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1235595	55994342	3134641	333	1095											
ZNF835	90485	broad.mit.edu	37	chr19	57175754	57175754	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tagggcttctcctccgtgtgGatgcgctggtggcggatgag	4	11	17	9	3	1	1	0	1	1	0	3	3	2	3	2	5	1	2	2	5	1	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:57175754G>A	uc010ygo.1	-	2	879	c.879C>T	c.(877-879)ATC>ATT	p.I293I	ZNF835_uc010ygn.1_Silent_p.I271I	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CCTCCGTGTGGATGCGCTGGT	0.682													6	4					0	0	0	0	A	57175754	A	A	57175754	2	1	4	1	0	0	0	0	0	0	0	1	18253	1164	41	2		2	ZNF835	19	57175754	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1181412	57175754	1953229	334	1096											
ZIK1	284307	broad.mit.edu	37	chr19	58101557	58101557	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcagaaaccatacttggtTggagaatgtacaaaccatca	15	8	10	8	0	1	2	1	0	0	2	1	3	1	2	2	3	4	3	2	3	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr19:58101557T>G	uc002qpg.2	+	4	475	c.378T>G	c.(376-378)GTT>GTG	p.V126V	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Silent_p.V71V|ZIK1_uc002qpi.2_Silent_p.V113V|ZIK1_uc002qpj.2_Silent_p.V23V	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	126	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CATACTTGGTTGGAGAATGTA	0.463													41	84					0	0	0	0	G	58101557	G	G	58101557	2	3	4	1	0	0	0	0	0	0	0	1	17750	1799	63	5		5	ZIK1	19	58101557	Silent	SNP	T	TCGA-BA-4077-01B-01D-1434-08	925803	58101557	1027426	335	1097											
SNTA1	6640	broad.mit.edu	37	chr20	32026798	32026798	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaatcccttgaagatcttGgaaatgagaataggcatctt	13	11	9	8	0	2	3	0	2	2	2	3	5	3	4	2	2	0	1	2	2	5	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr20:32026798G>A	uc002wzd.1	-	2	617	c.345C>T	c.(343-345)TCC>TCT	p.S115S	SNTA1_uc010zuf.1_Silent_p.S115S	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	115	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						TGAAGATCTTGGAAATGAGAA	0.517													15	214					0	0	0	0	A	32026798	A	A	32026798	2	1	4	1	0	0	0	0	0	0	0	1	14935	1335	47	4		4	SNTA1	20	32026798	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08		32026798	30998722	336	1098											
EDEM2	55741	broad.mit.edu	37	chr20	33730263	33730263	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaccactctttggaattCtgagacattccccaaaatct	12	13	4	12	0	4	1	1	1	3	1	5	3	5	2	3	1	1	0	3	1	4	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr20:33730263C>A	uc002xbo.2	-	4	377	c.277G>T	c.(277-279)GAA>TAA	p.E93*	EDEM2_uc010zuv.1_Nonsense_Mutation_p.E52*|EDEM2_uc010zus.1_5'UTR|EDEM2_uc002xbq.2_Nonsense_Mutation_p.E56*|EDEM2_uc010zut.1_Nonsense_Mutation_p.E52*|EDEM2_uc002xbp.2_5'UTR|EDEM2_uc002xbn.2_5'UTR|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_5'UTR	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	93					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			CTTTGGAATTCTGAGACATTC	0.448													14	65					2.32078e-09	2.44381e-09	1	0	A	33730263	A	A	33730263	4	1	4	1	0	0	0	0	0	1	0	0	4934	922	32	2	1491	2	EDEM2	20	33730263	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1703465	33730263	29295257	337	1099											
NDRG3	57446	broad.mit.edu	37	chr20	35299789	35299789	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtccacaacattggttgtCaggccagagagctgaaaaga	14	8	11	8	0	1	3	1	1	0	2	2	4	2	3	2	2	2	2	2	2	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr20:35299789C>G	uc002xfw.2	-	9	625	c.543G>C	c.(541-543)CTG>CTC	p.L181L	NDRG3_uc002xfx.2_Silent_p.L169L|NDRG3_uc010zvq.1_Silent_p.L86L|NDRG3_uc010zvr.1_Silent_p.L69L	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	181					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)				CATTGGTTGTCAGGCCAGAGA	0.289													35	56					0	0	0	0	G	35299789	G	G	35299789	2	3	4	1	0	0	0	0	0	0	0	1	10307	813	29	2		2	NDRG3	20	35299789	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1569526	35299789	27725731	338	1100											
SLC32A1	140679	broad.mit.edu	37	chr20	37356988	37356988	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacagcggcgacgggcgcctGaagtcctgggggctgacgct	6	6	17	12	5	0	2	0	2	0	0	1	3	1	2	2	4	2	2	2	4	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr20:37356988G>A	uc002xjc.2	+	2	1547	c.1284G>A	c.(1282-1284)CTG>CTA	p.L428L		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	428	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	ACGGGCGCCTGAAGTCCTGGG	0.652													13	40					0	0	0	0	A	37356988	A	A	37356988	2	1	4	1	0	0	0	0	0	0	0	1	14629	1277	45	2		2	SLC32A1	20	37356988	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2057199	37356988	25668532	339	1101											
PPP1R16B	26051	broad.mit.edu	37	chr20	37535627	37535627	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctgtgtttcagatgcaGatggcagagctattggtgtc	7	14	12	8	0	1	3	1	0	0	3	3	3	2	3	1	2	2	4	1	2	1	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr20:37535627G>T	uc002xje.2	+	8	1017	c.828G>T	c.(826-828)CAG>CAT	p.Q276H	PPP1R16B_uc010ggc.2_Missense_Mutation_p.Q234H	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	276	ANK 4.				regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TTCAGATGCAGATGGCAGAGC	0.532													17	163					4.63292e-17	5.04885e-17	1	0	T	37535627	T	T	37535627	3	4	4	1	0	0	0	0	1	0	0	0	12426	933	33	2	854	2	PPP1R16B	20	37535627	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	178639	37535627	25489893	340	1102											
TOP1	7150	broad.mit.edu	37	chr20	39742733	39742733	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggtcaggaatatgtggtaGagtttgacttcctcgggaag	10	12	14	5	1	1	2	1	1	0	1	3	4	2	4	1	4	0	2	1	4	4	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr20:39742733G>C	uc002xjl.2	+	15	1822	c.1576G>C	c.(1576-1578)GAG>CAG	p.E526Q	uc002xjn.1_Intron	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	526					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	ATATGTGGTAGAGTTTGACTT	0.468			T	NUP98	AML*								10	157					0	0	0	0	C	39742733	C	C	39742733	3	2	4	1	0	0	0	0	1	0	0	0	16430	943	33	2	1634	2	TOP1	20	39742733	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	2207106	39742733	23282787	341	1103											
ADNP	23394	broad.mit.edu	37	chr20	49510939	49510939	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	taggggcaattaaggagaatCctattttcaaagtcttcact	13	13	8	7	0	3	1	2	0	1	1	4	2	4	1	1	3	0	1	1	3	6	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr20:49510939C>G	uc002xvt.1	-	5	657	c.312G>C	c.(310-312)AGG>AGC	p.R104S	ADNP_uc002xvu.1_Missense_Mutation_p.R104S	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	104						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TAAGGAGAATCCTATTTTCAA	0.408													32	160					0	0	0	0	G	49510939	G	G	49510939	3	3	4	1	0	0	0	0	1	0	0	0	323	854	30	2	3000	2	ADNP	20	49510939	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	9768206	49510939	13514581	342	1104											
PRPF6	24148	broad.mit.edu	37	chr20	62648154	62648154	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgtgattgggattgggattGaggaggaagatcggaagcat	11	9	17	4	2	0	3	0	2	0	1	1	8	0	8	1	5	1	1	1	5	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr20:62648154G>C	uc002yho.2	+	12	1771	c.1603G>C	c.(1603-1605)GAG>CAG	p.E535Q	PRPF6_uc002yhp.2_Missense_Mutation_p.E535Q	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	535					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GATTGGGATTGAGGAGGAAGA	0.542													7	75					0	0	0	0	C	62648154	C	C	62648154	3	2	4	1	0	0	0	0	1	0	0	0	12636	1291	45	2	1649	2	PRPF6	20	62648154	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	13137215	62648154	377366	343	1105											
TPTE	7179	broad.mit.edu	37	chr21	10959802	10959802	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaaagtcgtgctaacacacTttagccaccaaaaaaaaagc	18	6	7	10	1	0	0	0	0	0	0	1	1	0	1	2	1	4	1	2	1	7	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr21:10959802T>C	uc002yip.1	-	8	542	c.174_splice	c.e8-1	p.S58_splice	TPTE_uc002yis.1_Splice_Site|TPTE_uc002yiq.1_Splice_Site_p.S40_splice|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCTAACACACTTTAGCCACCA	0.318													23	91					0	0	0	0	C	10959802	C	C	10959802	5	2	4	1	0	0	0	0	0	0	1	0	16497	1623	56	5	1551	5	TPTE	21	10959802	Splice_Site	SNP	T	TCGA-BA-4077-01B-01D-1434-08		10959802	37170093	344	1106											
KCNJ15	3772	broad.mit.edu	37	chr21	39671931	39671931	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagagccccttcctcattCtgcccatgacattctaccat	8	12	5	16	0	3	2	1	2	2	1	4	3	4	2	5	0	3	0	5	0	1	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr21:39671931C>T	uc002ywv.2	+	4	1050	c.748C>T	c.(748-750)CTG>TTG	p.L250L	KCNJ15_uc002yww.2_Silent_p.L250L|KCNJ15_uc002ywx.2_Silent_p.L250L	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	250	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						CTTCCTCATTCTGCCCATGAC	0.557													35	66					0	0	0	0	T	39671931	T	T	39671931	2	4	4	1	0	0	0	0	0	0	0	1	8088	912	32	2		2	KCNJ15	21	39671931	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	28712129	39671931	8457964	345	1107											
COL6A1	1291	broad.mit.edu	37	chr21	47422131	47422131	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcctgccctttgctatgcaGagccatcaagagcctgcagt	8	11	9	13	0	1	2	1	0	0	2	2	2	2	2	4	0	6	3	4	0	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr21:47422131G>C	uc002zhu.1	+	32	2169	c.2067_splice	c.e32-1	p.E689_splice	COL6A1_uc010gqd.1_Splice_Site_p.E20_splice|COL6A1_uc002zhv.1_Splice_Site_p.E20_splice|COL6A1_uc002zhw.1_5'Flank	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor						axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	TTGCTATGCAGAGCCATCAAG	0.711													2	13					0	0	0	0	C	47422131	C	C	47422131	5	2	4	1	0	0	0	0	0	0	1	0	3714	956	33	2	2192	2	COL6A1	21	47422131	Splice_Site	SNP	G	TCGA-BA-4077-01B-01D-1434-08	7750200	47422131	707764	346	1108											
LSS	4047	broad.mit.edu	37	chr21	47636350	47636350	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttccgcggcactcagccgaaCggcgtagcagtagctcatgg	8	7	13	13	5	2	0	2	0	0	0	3	1	3	0	2	3	4	5	2	3	3	3	rs150614553		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr21:47636350C>T	uc002zij.2	-	7	815	c.736G>A	c.(736-738)GTT>ATT	p.V246I	LSS_uc011afv.1_Missense_Mutation_p.V235I|LSS_uc002zil.2_Missense_Mutation_p.V246I|LSS_uc002zik.2_Missense_Mutation_p.V166I	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	246					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					CTCAGCCGAACGGCGTAGCAG	0.652													34	48					0	0	0	0	T	47636350	T	T	47636350	3	4	4	1	0	0	0	0	1	0	0	0	9115	536	19	1	1526	1	LSS	21	47636350	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	214219	47636350	493545	347	1109											
SMARCB1	6598	broad.mit.edu	37	chr22	24135750	24135750	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttgtctgttacagatcaCggatacacgactctagccac	10	12	8	11	2	3	1	1	0	2	1	3	3	3	2	1	1	3	2	1	1	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr22:24135750C>A	uc002zyb.2	+	3	444	c.237C>A	c.(235-237)CAC>CAA	p.H79Q	SMARCB1_uc002zyg.2_Missense_Mutation_p.H79Q|SMARCB1_uc011ajb.1_Missense_Mutation_p.H70Q|SMARCB1_uc002zya.2_Missense_Mutation_p.H79Q|SMARCB1_uc002zyc.2_Missense_Mutation_p.H70Q|SMARCB1_uc002zyd.2_Missense_Mutation_p.H70Q|SMARCB1_uc002zye.1_Missense_Mutation_p.H42Q|SMARCB1_uc002zyf.1_RNA|SMARCB1_uc010gue.1_Intron	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	79					cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(2)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				TTACAGATCACGGATACACGA	0.537			D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				95	178					1.30168e-36	1.45482e-36	1	0	A	24135750	A	A	24135750	3	1	4	1	0	0	0	0	1	0	0	0	14838	535	19	3	247	3	SMARCB1	22	24135750	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08		24135750	27168816	348	1110											
CABIN1	23523	broad.mit.edu	37	chr22	24439409	24439409	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtcaacctctggtataagaTtggacatgtggccctgaggc	9	11	12	9	0	2	2	1	1	1	1	2	3	2	3	2	4	1	1	2	4	3	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr22:24439409T>C	uc002zzi.1	+	6	516	c.389T>C	c.(388-390)ATT>ACT	p.I130T	CABIN1_uc002zzj.1_Missense_Mutation_p.I130T|CABIN1_uc002zzl.1_Missense_Mutation_p.I130T|CABIN1_uc010guk.1_Missense_Mutation_p.I85T|CABIN1_uc002zzk.1_Missense_Mutation_p.I85T	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	130	TPR 3.				cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TGGTATAAGATTGGACATGTG	0.478													43	111					0	0	0	0	C	24439409	C	C	24439409	3	2	4	1	0	0	0	0	1	0	0	0	2540	1493	52	5	407	5	CABIN1	22	24439409	Missense_Mutation	SNP	T	TCGA-BA-4077-01B-01D-1434-08	303659	24439409	26865157	349	1111											
SUSD2	56241	broad.mit.edu	37	chr22	24580746	24580746	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccctcaggaatgccctactCacaggagtggactgcaaagt	11	8	10	12	0	2	0	2	0	0	0	3	3	3	3	2	3	3	1	2	3	3	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr22:24580746C>G	uc002zzn.1	+	5	664	c.620C>G	c.(619-621)TCA>TGA	p.S207*		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	207	Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ATGCCCTACTCACAGGAGTGG	0.607													11	52					0	0	0	0	G	24580746	G	G	24580746	4	3	4	1	0	0	0	0	0	1	0	0	15474	838	29	2	638	2	SUSD2	22	24580746	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	141337	24580746	26723820	350	1112											
TBC1D10A	83874	broad.mit.edu	37	chr22	30689980	30689980	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcgggagaaggcgcacatGaaccattctgtcatatagag	12	9	12	8	2	2	3	1	1	1	2	3	4	2	3	1	2	1	2	1	2	4	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr22:30689980G>A	uc011akt.1	-	7	849	c.825C>T	c.(823-825)TTC>TTT	p.F275F	GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_RNA|GATSL3_uc003ahh.2_RNA|GATSL3_uc010gvq.2_RNA|GATSL3_uc003ahi.2_Silent_p.F133F|TBC1D10A_uc003ahj.3_Silent_p.F187F|TBC1D10A_uc010gvu.2_Silent_p.F282F|TBC1D10A_uc003ahk.3_Silent_p.F275F	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	275	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						AGGCGCACATGAACCATTCTG	0.592													22	152					0	0	0	0	A	30689980	A	A	30689980	2	1	4	1	0	0	0	0	0	0	0	1	15664	1281	45	2		2	TBC1D10A	22	30689980	Silent	SNP	G	TCGA-BA-4077-01B-01D-1434-08	6109234	30689980	20614586	351	1113											
DEPDC5	9681	broad.mit.edu	37	chr22	32210996	32210996	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatctgtgcgagagcgagaGagtcacagtcgaaagagtgc	13	6	15	7	3	2	4	1	0	1	4	3	8	2	4	0	0	3	0	0	0	1	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr22:32210996G>C	uc003als.2	+	21	1606	c.1464G>C	c.(1462-1464)GAG>GAC	p.E488D	DEPDC5_uc011als.1_Missense_Mutation_p.E488D|DEPDC5_uc011alu.1_Missense_Mutation_p.E488D|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.E488D|DEPDC5_uc003alr.1_Missense_Mutation_p.E488D|DEPDC5_uc011alt.1_Missense_Mutation_p.E460D	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	488					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						GAGAGCGAGAGAGTCACAGTC	0.532													5	169					0	0	0	0	C	32210996	C	C	32210996	3	2	4	1	0	0	0	0	1	0	0	0	4464	933	33	2	1542	2	DEPDC5	22	32210996	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	1521016	32210996	19093570	352	1114											
DEPDC5	9681	broad.mit.edu	37	chr22	32215016	32215016	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gataactggcagatgtcctgGagaacatgatggagccacca	13	7	12	9	0	0	3	0	1	0	2	1	6	1	4	3	3	3	1	3	3	2	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr22:32215016G>A	uc003als.2	+	22	1817	c.1675G>A	c.(1675-1677)GAG>AAG	p.E559K	DEPDC5_uc011als.1_Missense_Mutation_p.E559K|DEPDC5_uc011alu.1_Missense_Mutation_p.E559K|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.E559K|DEPDC5_uc003alu.2_5'UTR|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alt.1_Missense_Mutation_p.E531K	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	559					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						AGATGTCCTGGAGAACATGAT	0.498													5	151					0	0	0	0	A	32215016	A	A	32215016	3	1	4	1	0	0	0	0	1	0	0	0	4464	1175	41	2	1775	2	DEPDC5	22	32215016	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	4020	32215016	19089550	353	1115											
TUBGCP6	85378	broad.mit.edu	37	chr22	50656807	50656807	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagctgacggaactgcacaGagccggccatgtggctcagc	9	5	14	13	2	1	2	1	1	0	1	1	3	1	3	2	3	5	4	2	3	1	0			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chr22:50656807G>A	uc003bkb.1	-	23	5491	c.4979C>T	c.(4978-4980)TCT>TTT	p.S1660F	TUBGCP6_uc003bka.1_Intron|TUBGCP6_uc010har.1_Missense_Mutation_p.S1652F|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1660					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GAACTGCACAGAGCCGGCCAT	0.657													14	59					0	0	0	0	A	50656807	A	A	50656807	3	1	4	1	0	0	0	0	1	0	0	0	16838	942	33	2	492	2	TUBGCP6	22	50656807	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	18441791	50656807	647759	354	1116											
MXRA5	25878	broad.mit.edu	37	chrX	3228112	3228112	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtactccgtctccatcctgCatacataggtacccctgtca	8	11	6	16	2	2	0	1	0	1	0	5	0	4	0	5	1	4	3	5	1	4	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:3228112C>A	uc004crg.3	-	7	8289	c.8132G>T	c.(8131-8133)TGC>TTC	p.C2711F		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2711	Ig-like C2-type 11.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTCCATCCTGCATACATAGGT	0.607													36	112					3.11337e-16	3.35937e-16	1	0	A	3228112	A	A	3228112	3	1	4	1	0	0	0	0	1	0	0	0	10056	710	25	4	358	4	MXRA5	23	3228112	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08		3228112	152042448	355	1117											
ARHGAP6	395	broad.mit.edu	37	chrX	11187736	11187736	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattctttgtctgatgacttCtgcttgtgcagcaggttggg	6	16	12	7	0	3	2	0	2	3	0	3	2	3	2	0	2	3	4	0	2	1	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:11187736C>G	uc004cup.1	-	9	2571	c.1698G>C	c.(1696-1698)CAG>CAC	p.Q566H	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.Q566H|ARHGAP6_uc004cum.1_Missense_Mutation_p.Q363H|ARHGAP6_uc004cun.1_Missense_Mutation_p.Q386H|ARHGAP6_uc010neb.1_Missense_Mutation_p.Q388H|ARHGAP6_uc011mif.1_Missense_Mutation_p.Q363H	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	566	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						CTGATGACTTCTGCTTGTGCA	0.438													29	214					0	0	0	0	G	11187736	G	G	11187736	3	3	4	1	0	0	0	0	1	0	0	0	887	912	32	2	1368	2	ARHGAP6	23	11187736	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	7959624	11187736	144082824	356	1118											
GRPR	2925	broad.mit.edu	37	chrX	16142343	16142343	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctttgggagacctgctcctCctaataacgtgtgctccagt	7	12	10	12	1	0	1	0	0	0	1	3	2	3	1	4	1	3	3	4	1	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:16142343C>T	uc004cxj.2	+	1	920	c.267C>T	c.(265-267)CTC>CTT	p.L89L		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	89	Helical; Name=2; (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					ACCTGCTCCTCCTAATAACGT	0.483											OREG0019682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	349					0	0	0	0	T	16142343	T	T	16142343	2	4	4	1	0	0	0	0	0	0	0	1	6847	842	30	2		2	GRPR	23	16142343	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	4954607	16142343	139128217	357	1119											
MAGEB1	4112	broad.mit.edu	37	chrX	30269381	30269381	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caggaaaaatatctgaagtaCgagcaggtgcccaacagtga	16	6	11	8	1	1	2	0	2	1	0	1	4	1	3	1	2	4	2	1	2	6	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:30269381C>A	uc004dcc.2	+	4	1091	c.771C>A	c.(769-771)TAC>TAA	p.Y257*	MAGEB1_uc004dcd.2_Nonsense_Mutation_p.Y257*|MAGEB1_uc004dce.2_Nonsense_Mutation_p.Y257*	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	257	MAGE.										0						ATCTGAAGTACGAGCAGGTGC	0.493													35	85					2.42023e-17	2.6441e-17	1	0	A	30269381	A	A	30269381	4	1	4	1	0	0	0	0	0	1	0	0	9225	547	19	3	773	3	MAGEB1	23	30269381	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	14127038	30269381	125001179	358	1120											
FAM47A	158724	broad.mit.edu	37	chrX	34148687	34148687	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgaatcttgggaggctccGagaattgatgggactctgga	9	10	14	8	2	2	2	0	1	2	1	4	7	3	5	1	4	0	1	1	4	2	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:34148687G>A	uc004ddg.2	-	1	1742	c.1709C>T	c.(1708-1710)TCG>TTG	p.S570L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	570										ovary(4)|central_nervous_system(1)	5						GGGAGGCTCCGAGAATTGATG	0.522													10	125					0	0	0	0	A	34148687	A	A	34148687	3	1	4	1	0	0	0	0	1	0	0	0	5601	1059	37	1	670	1	FAM47A	23	34148687	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	3879306	34148687	121121873	359	1121											
SLC9A7	84679	broad.mit.edu	37	chrX	46466624	46466624	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatcagagtcttcctctctCagtggctcttggttctgaaa	9	14	8	10	0	6	2	2	1	4	1	8	2	7	2	1	2	0	2	1	2	2	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:46466624C>A	uc004dgu.1	-	17	1949	c.1941G>T	c.(1939-1941)CTG>CTT	p.L647L		NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	647					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						CTTCCTCTCTCAGTGGCTCTT	0.498													9	78					0.00829132	0.00846567	1	0	A	46466624	A	A	46466624	2	1	4	1	0	0	0	0	0	0	0	1	14783	813	29	2		2	SLC9A7	23	46466624	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	12317937	46466624	108803936	360	1122											
GPKOW	27238	broad.mit.edu	37	chrX	48972603	48972603	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggtgtttccgcttcctctCtgagttgtcctgctggatgt	4	16	11	10	1	1	1	0	1	1	0	5	2	4	2	3	2	1	4	3	2	1	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:48972603C>G	uc004dmr.2	-	7	995	c.988G>C	c.(988-990)GAG>CAG	p.E330Q		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	330						nucleus	nucleic acid binding			ovary(2)	2						CGCTTCCTCTCTGAGTTGTCC	0.572													11	126					0	0	0	0	G	48972603	G	G	48972603	3	3	4	1	0	0	0	0	1	0	0	0	6651	922	32	2	462	2	GPKOW	23	48972603	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	2505979	48972603	106297957	361	1123											
CCNB3	85417	broad.mit.edu	37	chrX	50089689	50089689	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggatgactttgtgtacatCtgtgatgataattatcagcg	10	15	11	5	1	2	3	1	3	1	0	2	4	2	4	0	1	2	1	0	1	3	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:50089689C>T	uc004dox.3	+	10	3991	c.3693C>T	c.(3691-3693)ATC>ATT	p.I1231I	CCNB3_uc004doy.2_Silent_p.I1231I|CCNB3_uc004doz.2_Silent_p.I127I|CCNB3_uc010njq.2_Silent_p.I123I|CCNB3_uc004dpa.2_Silent_p.I70I	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1231					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TTGTGTACATCTGTGATGATA	0.463													21	189					0	0	0	0	T	50089689	T	T	50089689	2	4	4	1	0	0	0	0	0	0	0	1	2929	903	32	2		2	CCNB3	23	50089689	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1117086	50089689	105180871	362	1124											
BMP15	9210	broad.mit.edu	37	chrX	50659550	50659551	+	Missense_Mutation	DNP	GA	TT	TT																															cttatgattgaggcaaatggGagtattttgtacaaggagta																										TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:50659550_50659551GA>TT	uc011mnw.1	+	2	1122_1123	c.1122_1123GA>TT	c.(1120-1125)GGGAGT>GGTTGT	p.S375C		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	375					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					AGGCAAATGGGAGTATTTTGTA	0.465													61	208					0	0	0	0	TT	50659551	TT	TT	50659550	3	4	4	1	0	0	0	0	1	0	0	0	1461	1161	41	2	1128	2	BMP15	23	50659550	Missense_Mutation	DNP	GA	TCGA-BA-4077-01B-01D-1434-08	569861	50659550	104611010	363	1125											
FAM120C	54954	broad.mit.edu	37	chrX	54112314	54112314	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgactccttcaaggatgctCtgtctcatcttttccacttt	6	18	5	12	0	4	1	2	1	3	0	7	2	6	2	2	1	1	1	2	1	1	5			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:54112314C>T	uc004dsz.3	-	13	2756	c.2673G>A	c.(2671-2673)CAG>CAA	p.Q891Q	FAM120C_uc011moh.1_Intron	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	891										ovary(1)|central_nervous_system(1)	2						CAAGGATGCTCTGTCTCATCT	0.478													54	74					0	0	0	0	T	54112314	T	T	54112314	2	4	4	1	0	0	0	0	0	0	0	1	5446	912	32	2		2	FAM120C	23	54112314	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	3452764	54112314	101158246	364	1126											
WNK3	65267	broad.mit.edu	37	chrX	54319739	54319739	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aatgtataactgatgcagctCctgcctcagacaaattgtca	13	11	7	10	0	2	2	2	1	0	1	3	2	3	2	2	0	4	3	2	0	4	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:54319739C>G	uc004dtd.1	-	9	2154	c.1715G>C	c.(1714-1716)GGA>GCA	p.G572A	WNK3_uc004dtc.1_Missense_Mutation_p.G572A	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	572					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TGATGCAGCTCCTGCCTCAGA	0.393													15	118					0	0	0	0	G	54319739	G	G	54319739	3	3	4	1	0	0	0	0	1	0	0	0	17447	855	30	2	3751	2	WNK3	23	54319739	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	207425	54319739	100950821	365	1127											
FGD1	2245	broad.mit.edu	37	chrX	54476730	54476730	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagtctttcttctcctcctCagtccttggggtggggaata	5	14	10	12	0	4	0	1	0	3	0	7	1	6	1	4	4	0	0	4	4	2	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:54476730C>G	uc004dtg.2	-	13	2754	c.2020G>C	c.(2020-2022)GAG>CAG	p.E674Q	FGD1_uc011moi.1_Missense_Mutation_p.E432Q	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	674	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TTCTCCTCCTCAGTCCTTGGG	0.393													15	235					0	0	0	0	G	54476730	G	G	54476730	3	3	4	1	0	0	0	0	1	0	0	0	5864	835	29	2	889	2	FGD1	23	54476730	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	156991	54476730	100793830	366	1128											
PFKFB1	5207	broad.mit.edu	37	chrX	54971904	54971904	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atagcggtagcgatatttatCttggtctcgcagtgcaaatt	10	14	10	7	3	2	0	0	0	2	0	3	1	2	0	0	2	3	3	0	2	5	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:54971904C>G	uc004dty.1	-	10	1137	c.1066G>C	c.(1066-1068)GAT>CAT	p.D356H	PFKFB1_uc010nkd.1_Missense_Mutation_p.D164H|PFKFB1_uc011mol.1_Missense_Mutation_p.D291H	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	356	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						CGATATTTATCTTGGTCTCGC	0.478													5	70					0	0	0	0	G	54971904	G	G	54971904	3	3	4	1	0	0	0	0	1	0	0	0	11815	913	32	2	369	2	PFKFB1	23	54971904	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	495174	54971904	100298656	367	1129											
BTK	695	broad.mit.edu	37	chrX	100615599	100615599	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccatggtaagttgctttcctCcaagataaaatattcatcac	13	13	5	10	0	2	1	2	0	0	1	4	1	4	1	3	1	1	3	3	1	5	6			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:100615599C>T	uc004ehg.2	-	8	926	c.733G>A	c.(733-735)GAG>AAG	p.E245K	BTK_uc004ehf.2_5'Flank|BTK_uc010nnh.2_5'Flank|BTK_uc010nni.2_5'Flank|BTK_uc004ehe.2_5'Flank|BTK_uc010nnj.2_5'Flank|BTK_uc010nnk.2_5'Flank|BTK_uc010nnl.2_5'Flank|BTK_uc010nnm.2_5'Flank|BTK_uc010nnn.2_Missense_Mutation_p.E245K|BTK_uc010nno.2_Missense_Mutation_p.E279K|BTK_uc004ehh.1_5'Flank|BTK_uc004ehi.2_Missense_Mutation_p.E245K	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	245	SH3.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TTGCTTTCCTCCAAGATAAAA	0.478									Agammaglobulinemia_X-linked				6	180					0	0	0	0	T	100615599	T	T	100615599	3	4	4	1	0	0	0	0	1	0	0	0	1562	864	30	2	1294	2	BTK	23	100615599	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	45643695	100615599	54654961	368	1130											
GPRASP1	9737	broad.mit.edu	37	chrX	101911992	101911992	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgggaggaggtcactgttCagttcaagcctggtccatgg	7	11	15	8	0	3	0	3	0	0	0	4	2	4	2	2	5	1	3	2	5	1	3			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:101911992C>T	uc004ejj.3	+	5	3952	c.3151C>T	c.(3151-3153)CAG>TAG	p.Q1051*	GPRASP1_uc004eji.3_Nonsense_Mutation_p.Q1051*|GPRASP1_uc010nod.2_Nonsense_Mutation_p.Q1051*	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1051	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2						GGTCACTGTTCAGTTCAAGCC	0.532													147	243					0	0	0	0	T	101911992	T	T	101911992	4	4	4	1	0	0	0	0	0	1	0	0	6761	827	29	2	3153	2	GPRASP1	23	101911992	Nonsense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	1296393	101911992	53358568	369	1131											
NRK	203447	broad.mit.edu	37	chrX	105149322	105149322	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgggaatctgctcccacagtCaaatccagcggatggtaaag	12	7	11	11	2	2	0	1	0	1	0	4	2	4	2	2	3	2	2	2	3	4	1			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:105149322C>G	uc004emd.2	+	10	1134	c.831C>G	c.(829-831)GTC>GTG	p.V277V	NRK_uc010npc.1_5'UTR	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	277	Protein kinase.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						CTCCCACAGTCAAATCCAGCG	0.373										HNSCC(51;0.14)			6	35					0	0	0	0	G	105149322	G	G	105149322	2	3	4	1	0	0	0	0	0	0	0	1	10709	813	29	2		2	NRK	23	105149322	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	3237330	105149322	50121238	370	1132											
ACSL4	2182	broad.mit.edu	37	chrX	108904860	108904860	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgcttgtaacttcactaGatctttcttacgatctgtta	8	18	5	10	1	4	1	1	0	3	1	5	2	5	1	1	0	3	3	1	0	4	7			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:108904860G>T	uc004eoi.2	-	15	2225	c.1720C>A	c.(1720-1722)CTA>ATA	p.L574I	ACSL4_uc004eoj.2_Missense_Mutation_p.L533I|ACSL4_uc004eok.2_Missense_Mutation_p.L533I	NM_022977	NP_075266	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	574	Cytoplasmic (Potential).				fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(1)|lung(1)|ovary(1)	3					Icosapent(DB00159)|Troglitazone(DB00197)	AACTTCACTAGATCTTTCTTA	0.358													21	143					1.37657e-19	1.51909e-19	1	0	T	108904860	T	T	108904860	3	4	4	1	0	0	0	0	1	0	0	0	179	933	33	2	427	2	ACSL4	23	108904860	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	3755538	108904860	46365700	371	1133											
ARHGAP4	393	broad.mit.edu	37	chrX	153178174	153178174	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggataaacttctccatgtCtcccccaaagagtctctggt	9	12	7	13	0	3	1	0	0	3	1	6	2	3	2	3	2	1	0	3	2	3	2			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:153178174C>T	uc004fjk.1	-	12	1564	c.1522G>A	c.(1522-1524)GAC>AAC	p.D508N	ARHGAP4_uc004fjj.1_5'Flank|ARHGAP4_uc011mzf.1_Missense_Mutation_p.D485N|ARHGAP4_uc004fjl.1_Missense_Mutation_p.D548N|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	508	Rho-GAP.				apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTCTCCATGTCTCCCCCAAAG	0.557													44	360					0	0	0	0	T	153178174	T	T	153178174	3	4	4	1	0	0	0	0	1	0	0	0	885	913	32	2	1362	2	ARHGAP4	23	153178174	Missense_Mutation	SNP	C	TCGA-BA-4077-01B-01D-1434-08	44273314	153178174	2092386	372	1134											
OPN1MW	2652	broad.mit.edu	37	chrX	153496185	153496185	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttccaccctttgatggctGccctgccggccttctttgcc	2	13	8	18	1	1	1	0	1	1	0	2	1	2	1	7	2	3	1	7	2	0	4			TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:153496185G>T	uc004fkd.2	+	5	995	c.913G>T	c.(913-915)GCC>TCC	p.A305S		NM_000513	NP_000504	P04001	OPSG_HUMAN	opsin 1 (cone pigments), medium-wave-sensitive	305	Helical; Name=7; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTTGATGGCTGCCCTGCCGGC	0.552													86	364					1.84561e-53	2.07869e-53	1	0	T	153496185	T	T	153496185	3	4	4	1	0	0	0	0	1	0	0	0	10932	1319	46	4	2050	4	OPN1MW	23	153496185	Missense_Mutation	SNP	G	TCGA-BA-4077-01B-01D-1434-08	318011	153496185	1774375	373	1135											
PLXNA3	55558	broad.mit.edu	37	chrX	153689684	153689684	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcatacgtggaattccccatCggctgctcctggcgcggcgt	5	10	12	14	5	1	0	1	0	0	0	4	1	3	1	3	4	2	2	3	4	2	2	rs149751983		TCGA-BA-4077-01B-01D-1434-08	TCGA-BA-4077-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b37211a-2150-4d33-bc6a-9d6a0a429708	cdf04127-a808-4733-919c-377f25f12306	g.chrX:153689684C>T	uc004flm.2	+	3	1013	c.840C>T	c.(838-840)ATC>ATT	p.I280I		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	280	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AATTCCCCATCGGCTGCTCCT	0.637													27	198					0	0	0	0	T	153689684	T	T	153689684	2	4	4	1	0	0	0	0	0	0	0	1	12176	874	31	1		1	PLXNA3	23	153689684	Silent	SNP	C	TCGA-BA-4077-01B-01D-1434-08	193499	153689684	1580876	374	1136											
KIF1B	23095	broad.mit.edu	37	chr1	10386207	10386207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgtgtgaacgagcgccttgCcgaccgcacaccctccccca	7	6	9	19	4	0	1	0	1	0	0	1	3	1	1	6	0	3	1	6	0	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:10386207C>T	uc001aqx.3	+	27	2916	c.2714C>T	c.(2713-2715)GCC>GTC	p.A905V	KIF1B_uc001aqw.3_Missense_Mutation_p.A859V|KIF1B_uc001aqy.2_Missense_Mutation_p.A879V|KIF1B_uc001aqz.2_Missense_Mutation_p.A905V|KIF1B_uc001ara.2_Missense_Mutation_p.A865V|KIF1B_uc001arb.2_Missense_Mutation_p.A891V	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	905					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GAGCGCCTTGCCGACCGCACA	0.542													5	244					0	0	0	0	T	10386207	T	T	10386207	3	4	5	1	0	0	0	0	1	0	0	0	8323	739	26	4	4159	4	KIF1B	1	10386207	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08		10386207	238864414	1	1137											
CELA3B	23436	broad.mit.edu	37	chr1	22304901	22304901	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctctcgcccttccagccGcgttgtcaatggtgaggatg	5	12	11	13	3	2	1	1	1	1	0	5	2	4	2	4	2	1	1	4	2	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:22304901G>T	uc001bfk.2	+	2	198	c.83G>T	c.(82-84)CGC>CTC	p.R28L	CELA3B_uc009vqf.2_Missense_Mutation_p.R27L	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	28					cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						CCTTCCAGCCGCGTTGTCAAT	0.582													42	23					6.27289e-28	8.06515e-28	1	0	T	22304901	T	T	22304901	3	4	5	1	0	0	0	0	1	0	0	0	3229	1087	38	3	89	3	CELA3B	1	22304901	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	11918694	22304901	226945720	2	1138											
CELA3B	23436	broad.mit.edu	37	chr1	22307604	22307604	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agggccccgagcaggtgatcCccatcaactctggggacctc	8	6	12	15	1	2	1	1	1	1	0	4	3	3	2	5	4	2	1	5	4	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:22307604C>A	uc001bfk.2	+	4	416	c.301C>A	c.(301-303)CCC>ACC	p.P101T	CELA3B_uc009vqf.2_Intron	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	101	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						GCAGGTGATCCCCATCAACTC	0.632											OREG0013210	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	28					2.165e-29	2.81227e-29	1	0	A	22307604	A	A	22307604	3	1	5	1	0	0	0	0	1	0	0	0	3229	623	22	4	315	4	CELA3B	1	22307604	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2703	22307604	226943017	3	1139											
KIAA1522	57648	broad.mit.edu	37	chr1	33237516	33237516	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggccccccagaaaccactGcgaagggccctgtcagggcg	8	4	13	16	3	1	1	1	0	0	1	2	2	1	1	5	3	2	0	5	3	2	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:33237516G>A	uc001bvv.2	+	6	2695	c.2559G>A	c.(2557-2559)CTG>CTA	p.L853L	KIAA1522_uc001bvu.1_Silent_p.L912L|KIAA1522_uc010ohm.1_Silent_p.L864L|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	853	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGAAACCACTGCGAAGGGCCC	0.716													12	17					0	0	0	0	A	33237516	A	A	33237516	2	1	5	1	0	0	0	0	0	0	0	1	8277	1306	46	4		4	KIAA1522	1	33237516	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	10929912	33237516	216013105	4	1140											
ZMYM1	79830	broad.mit.edu	37	chr1	35578906	35578906	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaatattttagctgtggaaGagagtcatttgcaacccacg	14	11	9	7	1	1	1	1	0	0	1	1	3	1	2	1	1	3	2	1	1	6	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:35578906G>A	uc001bym.2	+	11	1623	c.1475G>A	c.(1474-1476)AGA>AAA	p.R492K	ZMYM1_uc001byn.2_Missense_Mutation_p.R492K|ZMYM1_uc010ohu.1_Missense_Mutation_p.R473K|ZMYM1_uc001byo.2_Missense_Mutation_p.R132K|ZMYM1_uc009vut.2_Missense_Mutation_p.R417K	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	492	TTF-type.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGCTGTGGAAGAGAGTCATTT	0.348													57	107					0	0	0	0	A	35578906	A	A	35578906	3	1	5	1	0	0	0	0	1	0	0	0	17766	942	33	2	1509	2	ZMYM1	1	35578906	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2341390	35578906	213671715	5	1141											
GNL2	29889	broad.mit.edu	37	chr1	38039946	38039946	+	Frame_Shift_Del	DEL	G	-	-																															ggcccaccctgctcttacctGgggggccacaagtggctctg																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:38039946delG	uc001cbk.2	-	12	1577	c.1414delC	c.(1414-1416)CAGfs	p.Q472fs		NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	472					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				GCTCTTACCTGGGGGGCCACA	0.542													---	---	---								-	38039946	-	-	38039946	7	5	5	1	0	1	0	1	0	0	0	0	6573	1357	47	0	801	0	GNL2	1	38039946	Frame_Shift_Del	DEL	G	TCGA-BA-4078-01A-01D-1434-08	2461040	38039946	211210675	6	1142											
ERMAP	114625	broad.mit.edu	37	chr1	43308691	43308691	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatgatggaggaaaaaacAcagcacctctagtcatttgt	14	11	8	8	0	3	1	2	1	1	0	3	3	3	3	1	2	2	1	1	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:43308691A>G	uc001cic.1	+	12	1486	c.1216A>G	c.(1216-1218)ACA>GCA	p.T406A	ERMAP_uc001cid.1_RNA|ERMAP_uc001cie.1_Missense_Mutation_p.T406A|ERMAP_uc001cif.1_Missense_Mutation_p.T316A	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	406	Cytoplasmic (Potential).|B30.2/SPRY.		Missing (in Sc-3 allele).			integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGGAAAAAACACAGCACCTCT	0.463													62	115					0	0	0	0	G	43308691	G	G	43308691	3	3	5	1	0	0	0	0	1	0	0	0	5258	159	6	5	1254	5	ERMAP	1	43308691	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	5268745	43308691	205941930	7	1143											
HECTD3	79654	broad.mit.edu	37	chr1	45472642	45472642	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttggtcaatgatgccttcTgcaataaatttacactccca	11	13	5	12	0	2	1	1	1	1	0	3	1	3	1	3	1	3	1	3	1	5	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:45472642T>A	uc009vxk.2	-	12	1700	c.1602A>T	c.(1600-1602)GCA>GCT	p.A534A	HECTD3_uc001cmx.3_5'Flank|HECTD3_uc001cmy.3_Silent_p.A144A|HECTD3_uc010olh.1_Silent_p.A250A	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	534	HECT.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGATGCCTTCTGCAATAAATT	0.507													34	53					0	0	0	0	A	45472642	A	A	45472642	2	1	5	1	0	0	0	0	0	0	0	1	7080	1567	55	5		5	HECTD3	1	45472642	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	2163951	45472642	203777979	8	1144											
CYP4A11	1579	broad.mit.edu	37	chr1	47407066	47407066	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaggattccagagacatCacccaggagtctgctggggc	9	8	14	10	0	2	1	1	0	1	1	3	5	3	4	2	5	1	1	2	5	0	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:47407066C>A	uc001cqp.3	-	1	91	c.40G>T	c.(40-42)GAT>TAT	p.D14Y	CYP4A11_uc001cqq.2_Missense_Mutation_p.D14Y|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	14					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	CCAGAGACATCACCCAGGAGT	0.597													68	123					2.42712e-22	2.95762e-22	1	0	A	47407066	A	A	47407066	3	1	5	1	0	0	0	0	1	0	0	0	4200	826	29	2	1567	2	CYP4A11	1	47407066	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1934424	47407066	201843555	9	1145											
CYP4A22	284541	broad.mit.edu	37	chr1	47609432	47609432	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcttcatactctccctcAggaattctcagtcctacatc	8	15	3	15	0	6	0	3	0	4	0	10	1	7	1	2	1	2	0	2	1	3	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:47609432A>C	uc001cqv.1	+	6	687	c.636_splice	c.e6-2	p.R212_splice	CYP4A22_uc009vyo.2_Splice_Site_p.R212_splice|CYP4A22_uc009vyp.2_Intron	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,							endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						ACTCTCCCTCAGGAATTCTCA	0.512													52	73					0	0	0	0	C	47609432	C	C	47609432	5	2	5	1	0	0	0	0	0	0	1	0	4201	202	7	5	656	5	CYP4A22	1	47609432	Splice_Site	SNP	A	TCGA-BA-4078-01A-01D-1434-08	202366	47609432	201641189	10	1146											
ELAVL4	1996	broad.mit.edu	37	chr1	50659494	50659494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgctaacctctatgttagcGgccttcccaaaaccatgacc	11	10	6	14	1	1	1	0	1	1	0	2	1	2	1	5	1	4	2	5	1	5	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:50659494G>A	uc001csb.2	+	4	680	c.412G>A	c.(412-414)GGC>AGC	p.G138S	ELAVL4_uc001cry.3_Missense_Mutation_p.G141S|ELAVL4_uc001crz.3_Missense_Mutation_p.G138S|ELAVL4_uc001csa.3_Missense_Mutation_p.G155S|ELAVL4_uc001csc.3_Missense_Mutation_p.G138S|ELAVL4_uc009vyu.2_Missense_Mutation_p.G143S|ELAVL4_uc010omz.1_Missense_Mutation_p.G143S	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	138	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						CTATGTTAGCGGCCTTCCCAA	0.488													105	140					0	0	0	0	A	50659494	A	A	50659494	3	1	5	1	0	0	0	0	1	0	0	0	5076	1116	39	1	525	1	ELAVL4	1	50659494	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3050062	50659494	198591127	11	1147											
C8B	732	broad.mit.edu	37	chr1	57425761	57425761	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcacaatcaatgggcaTcagggtaacatccacactcc	13	7	7	14	0	3	0	3	0	0	0	5	0	5	0	2	2	2	3	2	2	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:57425761T>A	uc001cyp.2	-	2	248	c.181A>T	c.(181-183)ATG>TTG	p.M61L	C8B_uc010oon.1_5'UTR|C8B_uc010ooo.1_Missense_Mutation_p.M9L	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	61					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TCAATGGGCATCAGGGTAACA	0.488													58	83					0	0	0	0	A	57425761	A	A	57425761	3	1	5	1	0	0	0	0	1	0	0	0	2428	1435	50	5	1638	5	C8B	1	57425761	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	6766267	57425761	191824860	12	1148											
PGM1	5236	broad.mit.edu	37	chr1	64117492	64117492	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgataactttgaatacagcgAcccagtggatggaagcattt	13	10	10	8	2	0	1	0	1	0	0	0	5	0	3	1	2	4	1	1	2	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:64117492A>T	uc001dbh.2	+	9	1646	c.1433A>T	c.(1432-1434)GAC>GTC	p.D478V	PGM1_uc010ooy.1_Missense_Mutation_p.D281V|PGM1_uc010ooz.1_Missense_Mutation_p.D496V	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	478					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						GAATACAGCGACCCAGTGGAT	0.463													21	53					0	0	0	0	T	64117492	T	T	64117492	3	4	5	1	0	0	0	0	1	0	0	0	11852	275	10	5	1771	5	PGM1	1	64117492	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	6691731	64117492	185133129	13	1149											
SGIP1	84251	broad.mit.edu	37	chr1	67155877	67155877	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttctccttacagtccaGaccttttagccctcccattc	6	16	3	16	0	2	1	0	0	2	1	6	1	4	1	5	0	2	0	5	0	2	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:67155877G>T	uc001dcr.2	+	17	1665	c.1448G>T	c.(1447-1449)AGA>ATA	p.R483I	SGIP1_uc010opd.1_Missense_Mutation_p.R83I|SGIP1_uc001dcs.2_Missense_Mutation_p.R83I|SGIP1_uc001dct.2_Missense_Mutation_p.R83I|SGIP1_uc009wat.2_Missense_Mutation_p.R277I	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	483	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TTACAGTCCAGACCTTTTAGC	0.443													87	167					1.29045e-55	1.95429e-55	1	0	T	67155877	T	T	67155877	3	4	5	1	0	0	0	0	1	0	0	0	14271	942	33	2	1514	2	SGIP1	1	67155877	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3038385	67155877	182094744	14	1150											
C1orf173	127254	broad.mit.edu	37	chr1	75037355	75037355	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgtttctgccgtttcacCacctccgtgtagaacttcca	6	13	8	14	2	2	1	1	0	1	1	4	1	4	1	5	1	2	4	5	1	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:75037355C>A	uc001dgg.2	-	14	4258	c.4039G>T	c.(4039-4041)GGT>TGT	p.G1347C		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1347	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GCCGTTTCACCACCTCCGTGT	0.537													44	66					2.14255e-21	2.55645e-21	1	0	A	75037355	A	A	75037355	3	1	5	1	0	0	0	0	1	0	0	0	2023	594	21	4	557	4	C1orf173	1	75037355	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	7881478	75037355	174213266	15	1151											
LPHN2	23266	broad.mit.edu	37	chr1	82409022	82409022	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctaccatgatacctcaccatAcagatggggaggaaagactg	14	7	10	10	0	1	3	1	1	0	2	1	5	1	5	3	3	3	0	3	3	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:82409022A>G	uc001dit.3	+	6	948	c.767A>G	c.(766-768)TAC>TGC	p.Y256C	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.Y256C|LPHN2_uc001div.2_Missense_Mutation_p.Y256C|LPHN2_uc009wcd.2_Missense_Mutation_p.Y256C	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	256	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ACCTCACCATACAGATGGGGA	0.393													60	88					0	0	0	0	G	82409022	G	G	82409022	3	3	5	1	0	0	0	0	1	0	0	0	8966	391	14	5	781	5	LPHN2	1	82409022	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	7371667	82409022	166841599	16	1152											
LPHN2	23266	broad.mit.edu	37	chr1	82445578	82445578	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattatcttcttggtgatcaCattgtgcaaaatggtgaagc	11	15	9	6	0	3	2	1	2	2	0	3	2	3	2	0	2	2	1	0	2	5	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:82445578C>A	uc001dit.3	+	17	3177	c.2996C>A	c.(2995-2997)ACA>AAA	p.T999K	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.T999K|LPHN2_uc001div.2_Missense_Mutation_p.T999K|LPHN2_uc009wcd.2_Missense_Mutation_p.T999K|LPHN2_uc001diw.2_Missense_Mutation_p.T583K|LPHN2_uc009wce.1_Missense_Mutation_p.T85K	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1012	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TTGGTGATCACATTGTGCAAA	0.299													31	62					2.05212e-20	2.42104e-20	1	0	A	82445578	A	A	82445578	3	1	5	1	0	0	0	0	1	0	0	0	8966	478	17	4	3054	4	LPHN2	1	82445578	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	36556	82445578	166805043	17	1153											
LPPR5	163404	broad.mit.edu	37	chr1	99387542	99387542	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtaagaaatgccaaacAcattaagcccaagcatagaa	19	6	6	10	0	0	2	0	0	0	2	1	2	1	2	3	0	4	2	3	0	7	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:99387542A>C	uc001dsb.2	-	4	916	c.694T>G	c.(694-696)TGT>GGT	p.C232G	LPPR5_uc001dsc.2_Missense_Mutation_p.C232G	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	232	Helical; (Potential).					integral to membrane	hydrolase activity				0						AATGCCAAACACATTAAGCCC	0.378													67	77					0	0	0	0	C	99387542	C	C	99387542	3	2	5	1	0	0	0	0	1	0	0	0	8978	159	6	5	283	5	LPPR5	1	99387542	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	16941964	99387542	149863079	18	1154											
COL11A1	1301	broad.mit.edu	37	chr1	103496734	103496734	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaagagtcacagtctggacTataatgctcacagtagtcat	13	11	9	8	0	4	2	3	1	1	1	4	3	4	3	0	1	1	2	0	1	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:103496734T>C	uc001dul.2	-	5	1036	c.718A>G	c.(718-720)AGT>GGT	p.S240G	COL11A1_uc001duk.2_Translation_Start_Site|COL11A1_uc001dum.2_Missense_Mutation_p.S240G|COL11A1_uc001dun.2_Missense_Mutation_p.S240G|COL11A1_uc009weh.2_Missense_Mutation_p.S240G	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	240	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGTCTGGACTATAATGCTCA	0.448													22	38					0	0	0	0	C	103496734	C	C	103496734	3	2	5	1	0	0	0	0	1	0	0	0	3682	1522	53	5	5111	5	COL11A1	1	103496734	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	4109192	103496734	145753887	19	1155											
COL11A1	1301	broad.mit.edu	37	chr1	103496752	103496752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actataatgctcacagtagtCatatgctgccttgggatcac	11	12	8	10	0	3	0	3	0	0	0	3	1	3	1	1	1	3	3	1	1	4	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:103496752C>T	uc001dul.2	-	5	1018	c.700G>A	c.(700-702)GAC>AAC	p.D234N	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.D234N|COL11A1_uc001dun.2_Missense_Mutation_p.D234N|COL11A1_uc009weh.2_Missense_Mutation_p.D234N	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	234	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCACAGTAGTCATATGCTGCC	0.443													21	41					0	0	0	0	T	103496752	T	T	103496752	3	4	5	1	0	0	0	0	1	0	0	0	3682	826	29	2	5129	2	COL11A1	1	103496752	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	18	103496752	145753869	20	1156											
COL11A1	1301	broad.mit.edu	37	chr1	103548502	103548502	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagaattgtgaaaatctaGtgcttttagtacatcaactg	13	14	9	5	0	2	2	1	1	1	1	2	3	2	2	0	1	3	2	0	1	7	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:103548502G>A	uc001dul.2	-	2	451	c.133C>T	c.(133-135)CTA>TTA	p.L45L	COL11A1_uc001dum.2_Silent_p.L45L|COL11A1_uc001dun.2_Silent_p.L45L|COL11A1_uc009weh.2_Silent_p.L45L	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	45	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGAAAATCTAGTGCTTTTAGT	0.333													51	87					0	0	0	0	A	103548502	A	A	103548502	2	1	5	1	0	0	0	0	0	0	0	1	3682	1020	36	4		4	COL11A1	1	103548502	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	51750	103548502	145702119	21	1157											
ATXN7L2	127002	broad.mit.edu	37	chr1	110032945	110032945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatgctatgtgtttagccGccggctggaccggttctgct	5	12	14	10	3	1	0	0	0	1	0	1	2	1	2	3	4	3	5	3	4	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:110032945G>A	uc001dxr.2	+	9	1304	c.1289G>A	c.(1288-1290)CGC>CAC	p.R430H	ATXN7L2_uc001dxs.2_Missense_Mutation_p.R57H|ATXN7L2_uc001dxt.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	430										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		GTGTTTAGCCGCCGGCTGGAC	0.577											OREG0013635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	62	72					0	0	0	0	A	110032945	A	A	110032945	3	1	5	1	0	0	0	0	1	0	0	0	1219	1087	38	1	1323	1	ATXN7L2	1	110032945	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	6484443	110032945	139217676	22	1158											
LRIG2	9860	broad.mit.edu	37	chr1	113652911	113652911	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacatcctgaaaccataattGctctaagaggcatgaatgtg	14	10	8	9	0	1	3	0	2	1	1	2	3	2	3	2	1	2	2	2	1	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:113652911G>T	uc001edf.1	+	13	1723	c.1525G>T	c.(1525-1527)GCT>TCT	p.A509S	LRIG2_uc009wgn.1_Missense_Mutation_p.A406S	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	509	Ig-like C2-type 1.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		AACCATAATTGCTCTAAGAGG	0.428													63	110					3.13296e-38	4.3571e-38	1	0	T	113652911	T	T	113652911	3	4	5	1	0	0	0	0	1	0	0	0	8995	1319	46	4	1575	4	LRIG2	1	113652911	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3619966	113652911	135597710	23	1159											
AMPD1	270	broad.mit.edu	37	chr1	115231345	115231345	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactttttcagcaaagttgcGcattgcatcatcaatttcta	11	15	5	10	1	4	0	3	0	1	0	4	0	4	0	0	0	3	4	0	0	3	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:115231345G>T	uc001efe.1	-	3	136	c.52C>A	c.(52-54)CGC>AGC	p.R18S	AMPD1_uc001eff.1_Missense_Mutation_p.R14S	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	18					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	GCAAAGTTGCGCATTGCATCA	0.423													68	138					4.66136e-34	6.26153e-34	1	0	T	115231345	T	T	115231345	3	4	5	1	0	0	0	0	1	0	0	0	585	1087	38	3	2247	3	AMPD1	1	115231345	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1578434	115231345	134019276	24	1160											
FLG	2312	broad.mit.edu	37	chr1	152280766	152280766	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcctagagccatctcctGattgttccttgtcatatgtt	7	16	8	10	0	2	2	1	1	1	1	4	2	3	2	4	0	2	2	4	0	2	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:152280766G>T	uc001ezu.1	-	3	6632	c.6596C>A	c.(6595-6597)TCA>TAA	p.S2199*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2199	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCATCTCCTGATTGTTCCTT	0.542									Ichthyosis				298	419					1.63887e-181	2.54936e-181	1	0	T	152280766	T	T	152280766	4	4	5	1	0	0	0	0	0	1	0	0	5954	1294	45	2	5593	2	FLG	1	152280766	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	37049421	152280766	96969855	25	1161											
OR10K2	391107	broad.mit.edu	37	chr1	158389859	158389859	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagcatcctggcttgaggaGtagttggactgaggccttaa	10	10	14	7	0	0	3	0	2	0	1	1	5	1	5	2	4	1	4	2	4	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:158389859G>A	uc010pii.1	-	1	798	c.798C>T	c.(796-798)TAC>TAT	p.Y266Y		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					GGCTTGAGGAGTAGTTGGACT	0.398													133	20					0	0	0	0	A	158389859	A	A	158389859	2	1	5	1	0	0	0	0	0	0	0	1	10968	1024	36	4		4	OR10K2	1	158389859	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	6109093	158389859	90860762	26	1162											
ARHGAP30	257106	broad.mit.edu	37	chr1	161018684	161018684	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttggcctctgtctcttccctActcccttctctcaatctgac	4	16	4	17	0	5	1	1	1	4	0	9	1	7	1	3	1	1	0	3	1	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:161018684A>G	uc001fxl.2	-	12	2473	c.2127T>C	c.(2125-2127)AGT>AGC	p.S709S	USF1_uc001fxi.2_5'Flank|USF1_uc001fxj.2_5'Flank|ARHGAP30_uc001fxk.2_Intron|ARHGAP30_uc001fxm.2_Silent_p.S555S|ARHGAP30_uc009wtx.2_Silent_p.S382S	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	709	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TCTCTTCCCTACTCCCTTCTC	0.527													263	354					0	0	0	0	G	161018684	G	G	161018684	2	3	5	1	0	0	0	0	0	0	0	1	879	388	14	5		5	ARHGAP30	1	161018684	Silent	SNP	A	TCGA-BA-4078-01A-01D-1434-08	2628825	161018684	88231937	27	1163											
GPA33	10223	broad.mit.edu	37	chr1	167024302	167024302	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaatgataatgagggctgcAaccacgcccaccgcgatgcc	11	5	10	15	3	0	2	0	2	0	0	0	3	0	2	5	1	3	2	5	1	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:167024302A>T	uc001gea.1	-	6	1082	c.738T>A	c.(736-738)GTT>GTA	p.V246V		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	246	Helical; (Potential).					integral to plasma membrane	receptor activity				0						TGAGGGCTGCAACCACGCCCA	0.577													91	16					0	0	0	0	T	167024302	T	T	167024302	2	4	5	1	0	0	0	0	0	0	0	1	6624	117	5	5		5	GPA33	1	167024302	Silent	SNP	A	TCGA-BA-4078-01A-01D-1434-08	6005618	167024302	82226319	28	1164											
CD247	919	broad.mit.edu	37	chr1	167408592	167408592	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgacttacgttatagagctGgttctggccctgctggtacg	6	13	12	10	2	1	2	0	1	1	1	1	2	1	2	1	3	4	5	1	3	4	5	rs74315290		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:167408592G>A	uc001gei.3	-	3	353	c.208C>T	c.(208-210)CAG>TAG	p.Q70*	CD247_uc001gej.3_Nonsense_Mutation_p.Q70*|CD247_uc001gek.2_Nonsense_Mutation_p.Q70*	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	70	Cytoplasmic (Potential).|ITAM 1.				interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			TTATAGAGCTGGTTCTGGCCC	0.592													60	120					0	0	0	0	A	167408592	A	A	167408592	4	1	5	1	0	0	0	0	0	1	0	0	3003	1357	47	4	310	4	CD247	1	167408592	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	384290	167408592	81842029	29	1165											
SELP	6403	broad.mit.edu	37	chr1	169580850	169580850	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctggagccataggcaaaagCagtgagcggatgaacacagt	14	5	14	8	1	0	2	0	2	0	0	0	4	0	4	1	3	4	3	1	3	4	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:169580850C>G	uc001ggi.3	-	7	1092	c.1027G>C	c.(1027-1029)GCT>CCT	p.A343P	SELP_uc001ggh.2_Missense_Mutation_p.A178P|SELP_uc009wvr.2_Missense_Mutation_p.A343P	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	343	Sushi 3.|Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TAGGCAAAAGCAGTGAGCGGA	0.532													130	21					0	0	0	0	G	169580850	G	G	169580850	3	3	5	1	0	0	0	0	1	0	0	0	14084	710	25	4	1505	4	SELP	1	169580850	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2172258	169580850	79669771	30	1166											
KCNT2	343450	broad.mit.edu	37	chr1	196285139	196285139	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcaaaagtcactccacacCtgagtaagtcatctaggctt	13	9	7	12	0	3	1	2	1	1	0	4	1	4	1	2	1	1	3	2	1	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:196285139C>G	uc001gtd.1	-	21	2426	c.2366G>C	c.(2365-2367)AGG>ACG	p.R789T	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.R715T|KCNT2_uc001gtf.1_Missense_Mutation_p.R765T|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.R765T|KCNT2_uc001gth.1_Missense_Mutation_p.R286T	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	789	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CACTCCACACCTGAGTAAGTC	0.393													29	7					0	0	0	0	G	196285139	G	G	196285139	3	3	5	1	0	0	0	0	1	0	0	0	8131	681	24	4	1073	4	KCNT2	1	196285139	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	26704289	196285139	52965482	31	1167											
F13B	2165	broad.mit.edu	37	chr1	197031010	197031010	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtggttttgtaccctgaagCgcaaccataacgcatgttct	10	12	9	10	2	1	1	0	1	1	0	1	1	1	1	2	1	4	5	2	1	4	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:197031010C>A	uc001gtt.1	-	3	399	c.355G>T	c.(355-357)GCT>TCT	p.A119S		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	119	Sushi 2.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TACCCTGAAGCGCAACCATAA	0.403													46	18					4.44401e-20	5.23314e-20	1	0	A	197031010	A	A	197031010	3	1	5	1	0	0	0	0	1	0	0	0	5366	768	27	3	1670	3	F13B	1	197031010	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	745871	197031010	52219611	32	1168											
CR1L	1379	broad.mit.edu	37	chr1	207871016	207871016	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggagccctgcagcccccaGatgtgaaggtgactagactc	9	7	12	13	0	0	4	0	2	0	2	1	5	0	5	3	2	3	1	3	2	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:207871016G>C	uc001hga.3	+	6	1152	c.1031G>C	c.(1030-1032)AGA>ACA	p.R344T	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	344	Sushi 5.					cytoplasm|extracellular region|membrane					0						GCAGCCCCCAGATGTGAAGGT	0.493													286	64					0	0	0	0	C	207871016	C	C	207871016	3	2	5	1	0	0	0	0	1	0	0	0	3856	942	33	2	1053	2	CR1L	1	207871016	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	10840006	207871016	41379605	33	1169											
CENPF	1063	broad.mit.edu	37	chr1	214819347	214819347	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagagaaactgaaagaacGcgagcgggagaatgattcac	16	4	13	8	4	1	5	1	2	0	3	1	8	1	5	0	1	3	1	0	1	4	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:214819347G>A	uc001hkm.2	+	13	6608	c.6434G>A	c.(6433-6435)CGC>CAC	p.R2145H		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2241	Potential.|2-1.|2 X 177 AA tandem repeats.|Interaction with NDE1 and NDEL1.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CTGAAAGAACGCGAGCGGGAG	0.468													94	13					0	0	0	0	A	214819347	A	A	214819347	3	1	5	1	0	0	0	0	1	0	0	0	3246	1087	38	1	6480	1	CENPF	1	214819347	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	6948331	214819347	34431274	34	1170											
ESRRG	2104	broad.mit.edu	37	chr1	216850746	216850746	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggttgacgctgtccgtcagGgaggctgggctggaaggttc	5	10	18	8	2	1	1	1	1	0	0	3	3	2	3	1	6	0	5	1	6	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:216850746G>A	uc001hkw.1	-	2	310	c.144C>T	c.(142-144)TCC>TCT	p.S48S	ESRRG_uc001hky.1_Silent_p.S25S|ESRRG_uc009xdp.1_Silent_p.S25S|ESRRG_uc001hkz.1_Silent_p.S25S|ESRRG_uc010puc.1_Silent_p.S25S|ESRRG_uc001hla.1_Silent_p.S25S|ESRRG_uc001hlb.1_Silent_p.S25S|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Silent_p.S25S|ESRRG_uc001hld.1_Silent_p.S25S|ESRRG_uc001hkx.1_Silent_p.S53S|ESRRG_uc009xdo.1_Silent_p.S25S|ESRRG_uc001hle.1_Silent_p.S25S	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	48					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TGTCCGTCAGGGAGGCTGGGC	0.532													81	21					0	0	0	0	A	216850746	A	A	216850746	2	1	5	1	0	0	0	0	0	0	0	1	5286	1219	43	4		4	ESRRG	1	216850746	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2031399	216850746	32399875	35	1171											
C1orf65	164127	broad.mit.edu	37	chr1	223568029	223568029	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggaggctggtggaagcCtgtcgcaagaggcacctaca	11	5	15	10	1	0	2	0	0	0	2	1	4	0	4	2	5	2	3	2	5	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:223568029C>G	uc001hoa.2	+	1	1315	c.1212C>G	c.(1210-1212)GCC>GCG	p.A404A		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	404										central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		TGGTGGAAGCCTGTCGCAAGA	0.622													43	6					0	0	0	0	G	223568029	G	G	223568029	2	3	5	1	0	0	0	0	0	0	0	1	2065	668	24	4		4	C1orf65	1	223568029	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	6717283	223568029	25682592	36	1172											
PARP1	142	broad.mit.edu	37	chr1	226549218	226549218	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagatacttcagatttacCtgagcaatatcatagacaat	16	11	6	8	0	2	4	2	1	0	3	2	4	2	4	1	0	4	2	1	0	6	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:226549218C>T	uc001hqd.3	-	23	3159	c.2988G>A	c.(2986-2988)CAG>CAA	p.Q996Q		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	996	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TCAGATTTACCTGAGCAATAT	0.473								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					50	6					0	0	0	0	T	226549218	T	T	226549218	2	4	5	1	0	0	0	0	0	0	0	1	11508	680	24	4		4	PARP1	1	226549218	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2981189	226549218	22701403	37	1173											
COG2	22796	broad.mit.edu	37	chr1	230827172	230827172	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtattaaactctgtgaagaaGatggaagagagcctgaaaag	17	8	12	4	0	1	5	0	2	1	3	1	7	1	6	1	1	2	1	1	1	8	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:230827172G>A	uc001htw.2	+	17	2128	c.1977G>A	c.(1975-1977)AAG>AAA	p.K659K	COG2_uc001htx.2_Silent_p.K658K|COG2_uc010pwc.1_Silent_p.K532K	NM_007357	NP_031383	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2 isoform	659					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				CTGTGAAGAAGATGGAAGAGA	0.463													62	7					0	0	0	0	A	230827172	A	A	230827172	2	1	5	1	0	0	0	0	0	0	0	1	3673	933	33	2		2	COG2	1	230827172	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	4277954	230827172	18423449	38	1174											
ARID4B	51742	broad.mit.edu	37	chr1	235345469	235345469	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accagacatcttttcgatctTtggccctgctgttttgaagt	7	16	8	10	1	2	2	0	1	2	1	3	3	2	2	2	1	1	2	2	1	1	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:235345469T>G	uc001hwq.2	-	20	3263	c.2765A>C	c.(2764-2766)AAA>ACA	p.K922T	ARID4B_uc001hwr.2_Missense_Mutation_p.K836T|ARID4B_uc001hws.3_Missense_Mutation_p.K836T|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.K603T	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	922					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TTTTCGATCTTTGGCCCTGCT	0.408													191	31					0	0	0	0	G	235345469	G	G	235345469	3	3	5	1	0	0	0	0	1	0	0	0	920	1841	64	5	1193	5	ARID4B	1	235345469	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	4518297	235345469	13905152	39	1175											
RYR2	6262	broad.mit.edu	37	chr1	237670115	237670115	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttggctggcagtatggtccgGtatgtaattttgaaatttat	9	17	11	4	1	0	1	0	1	0	0	1	1	1	1	1	4	0	5	1	4	5	8			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:237670115G>T	uc001hyl.1	+	23	2838	c.2718_splice	c.e23+1	p.P906_splice		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTATGGTCCGGTATGTAATTT	0.368													15	22					2.61681e-11	2.87713e-11	1	0	T	237670115	T	T	237670115	5	4	5	1	0	0	0	0	0	0	1	0	13834	1275	44	4	2809	4	RYR2	1	237670115	Splice_Site	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2324646	237670115	11580506	40	1176											
RYR2	6262	broad.mit.edu	37	chr1	237711878	237711879	+	Nonsense_Mutation	DNP	TG	AT	AT																															atccggcagggctggacttaTggcatccaacaggtacatgg																								rs113422365		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:237711878_237711879TG>AT	uc001hyl.1	+	26	3174_3175	c.3054_3055TG>AT	c.(3052-3057)TATGGC>TAATGC	p.1018_1019YG>*C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1018_1019	Cytoplasmic (By similarity).|2.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCTGGACTTATGGCATCCAACA	0.426													42	11					0	0	0	0	AT	237711879	AT	AT	237711878	4	1	5	1	0	0	0	0	0	1	0	0	13834	1471	51	5	3156	5	RYR2	1	237711878	Nonsense_Mutation	DNP	TG	TCGA-BA-4078-01A-01D-1434-08	41763	237711878	11538743	41	1177											
RYR2	6262	broad.mit.edu	37	chr1	237778123	237778123	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcctgctccaaatgaaactgCcagagccagttaaattgcag	13	8	9	11	0	0	2	0	1	0	1	1	2	1	2	4	0	5	3	4	0	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:237778123C>T	uc001hyl.1	+	37	5815	c.5695C>T	c.(5695-5697)CCA>TCA	p.P1899S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1899	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AATGAAACTGCCAGAGCCAGT	0.468													63	9					0	0	0	0	T	237778123	T	T	237778123	3	4	5	1	0	0	0	0	1	0	0	0	13834	739	26	4	5841	4	RYR2	1	237778123	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	66245	237778123	11472498	42	1178											
OPN3	23596	broad.mit.edu	37	chr1	241761198	241761198	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atataaggcatccaacagacCaggaaggtgaatatcattaa	18	8	8	7	0	1	2	1	1	0	1	2	3	2	3	2	3	1	1	2	3	7	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:241761198C>T	uc001hza.2	-	3	940	c.795G>A	c.(793-795)CTG>CTA	p.L265L	OPN3_uc001hzb.2_RNA|OPN3_uc001hzc.2_RNA	NM_014322	NP_055137	Q9H1Y3	OPN3_HUMAN	opsin 3	265	Helical; Name=6; (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|visual perception	integral to plasma membrane	G-protein coupled photoreceptor activity				0	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TCCAACAGACCAGGAAGGTGA	0.378													101	23					0	0	0	0	T	241761198	T	T	241761198	2	4	5	1	0	0	0	0	0	0	0	1	10935	581	21	4		4	OPN3	1	241761198	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3983075	241761198	7489423	43	1179											
OR2T12	127064	broad.mit.edu	37	chr1	248458280	248458280	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccaggagcattaacacacAgcagatgtacatggcgtttt	13	9	10	9	1	0	1	0	0	0	1	0	3	0	2	1	2	4	4	1	2	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:248458280A>T	uc010pzj.1	-	1	601	c.601T>A	c.(601-603)TGT>AGT	p.C201S		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATTAACACACAGCAGATGTAC	0.542													107	24					0	0	0	0	T	248458280	T	T	248458280	3	4	5	1	0	0	0	0	1	0	0	0	11073	188	7	5	364	5	OR2T12	1	248458280	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	6697082	248458280	792341	44	1180											
OR2G6	391211	broad.mit.edu	37	chr1	248685252	248685252	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggctgtgtggcccagctctAtgtggccatggggttgggct	3	12	17	9	0	1	0	0	0	1	0	1	0	1	0	2	6	1	4	2	6	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:248685252A>T	uc001ien.1	+	1	305	c.305A>T	c.(304-306)TAT>TTT	p.Y102F		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCCAGCTCTATGTGGCCATG	0.537													127	19					0	0	0	0	T	248685252	T	T	248685252	3	4	5	1	0	0	0	0	1	0	0	0	11054	449	16	5	307	5	OR2G6	1	248685252	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	226972	248685252	565369	45	1181											
OR14I1	401994	broad.mit.edu	37	chr1	248845040	248845040	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaactctacaaagaaaaccTcacaggaaaccagggccaac	20	3	6	12	0	2	1	1	0	1	1	2	2	2	2	3	2	5	0	3	2	8	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr1:248845040T>A	uc001ieu.1	-	1	566	c.566A>T	c.(565-567)GAG>GTG	p.E189V		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAAGAAAACCTCACAGGAAAC	0.483													60	14					0	0	0	0	A	248845040	A	A	248845040	3	1	5	1	0	0	0	0	1	0	0	0	11001	1551	54	5	373	5	OR14I1	1	248845040	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	159788	248845040	405581	46	1182											
NTSR2	23620	broad.mit.edu	37	chr2	11802345	11802345	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttagtgccaaggggagcaCgaaggacaccagcacattca	14	5	12	10	1	1	0	1	0	0	0	1	3	1	2	2	3	3	3	2	3	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:11802345C>A	uc002rbq.3	-	2	720	c.646G>T	c.(646-648)GTG>TTG	p.V216L		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	216	Extracellular (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	AAGGGGAGCACGAAGGACACC	0.647													99	146					1.90545e-35	2.60964e-35	1	0	A	11802345	A	A	11802345	3	1	5	1	0	0	0	0	1	0	0	0	10765	536	19	3	598	3	NTSR2	2	11802345	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08		11802345	231397028	47	1183											
APOB	338	broad.mit.edu	37	chr2	21242655	21242655	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagctggcgttggagtaaGcgcctgaggtgcagtaattc	8	10	16	7	2	0	1	0	1	0	0	1	3	0	3	1	4	3	5	1	4	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:21242655G>A	uc002red.2	-	19	3067	c.2939C>T	c.(2938-2940)GCT>GTT	p.A980V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	980					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTTGGAGTAAGCGCCTGAGGT	0.552													32	33					0	0	0	0	A	21242655	A	A	21242655	3	1	5	1	0	0	0	0	1	0	0	0	785	971	34	4	10796	4	APOB	2	21242655	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	9440310	21242655	221956718	48	1184											
CCDC85A	114800	broad.mit.edu	37	chr2	56602977	56602977	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaggttgtcatcaggggcTgatgggagtaacagttcacc	9	12	13	7	0	3	1	3	1	0	0	3	2	3	2	1	4	1	4	1	4	2	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:56602977T>A	uc002rzn.2	+	5	1981	c.1479T>A	c.(1477-1479)GCT>GCA	p.A493A		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	493										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CATCAGGGGCTGATGGGAGTA	0.408													49	57					0	0	0	0	A	56602977	A	A	56602977	2	1	5	1	0	0	0	0	0	0	0	1	2872	1567	55	5		5	CCDC85A	2	56602977	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	35360322	56602977	186596396	49	1185											
ATP6V1B1	525	broad.mit.edu	37	chr2	71189914	71189914	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctacacctccaggatcgagCggatcatcaccccgcgcctg	8	6	10	17	4	2	0	2	0	0	0	4	3	3	2	5	2	2	1	5	2	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:71189914C>G	uc002shj.2	+	9	880	c.793C>G	c.(793-795)CGG>GGG	p.R265G	ATP6V1B1_uc010fdv.2_Missense_Mutation_p.R265G|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.R223G	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	265					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						CAGGATCGAGCGGATCATCAC	0.582													35	83					0	0	0	0	G	71189914	G	G	71189914	3	3	5	1	0	0	0	0	1	0	0	0	1180	759	27	3	827	3	ATP6V1B1	2	71189914	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	14586937	71189914	172009459	50	1186											
PAIP2B	400961	broad.mit.edu	37	chr2	71429712	71429712	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgtatttgccatattggatCcattcattatgatggaacct	11	16	7	7	0	1	1	1	1	0	0	2	3	2	3	3	2	2	1	3	2	4	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:71429712C>A	uc002shu.2	-	2	195	c.8G>T	c.(7-9)GGA>GTA	p.G3V		NM_020459	NP_065192	Q9ULR5	PAI2B_HUMAN	poly(A) binding protein interacting protein 2B	3					negative regulation of translational initiation		protein binding|translation repressor activity, nucleic acid binding				0						CATATTGGATCCATTCATTAT	0.378													78	87					1.25089e-41	1.77892e-41	1	0	A	71429712	A	A	71429712	3	1	5	1	0	0	0	0	1	0	0	0	11452	855	30	2	375	2	PAIP2B	2	71429712	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	239798	71429712	171769661	51	1187											
REG1A	5967	broad.mit.edu	37	chr2	79348763	79348763	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caatgcctatcgctcctactGctactactttaatgaagacc	11	12	5	13	1	0	2	0	1	0	1	2	2	1	2	3	0	5	2	3	0	7	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:79348763G>T	uc002snz.2	+	3	243	c.140G>T	c.(139-141)TGC>TTC	p.C47F	REG1A_uc010ffx.1_Missense_Mutation_p.C47F|REG1A_uc010ysd.1_Missense_Mutation_p.C47F	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	47	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CGCTCCTACTGCTACTACTTT	0.542													133	199					1.3892e-51	2.07886e-51	1	0	T	79348763	T	T	79348763	3	4	5	1	0	0	0	0	1	0	0	0	13275	1319	46	4	146	4	REG1A	2	79348763	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	7919051	79348763	163850610	52	1188											
CTNNA2	1496	broad.mit.edu	37	chr2	80136777	80136777	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaggttccggccgtccctgGaggagaggctggagagcatc	7	6	16	12	2	0	2	0	0	0	2	3	5	2	3	4	6	1	3	4	6	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:80136777G>T	uc010ysh.1	+	6	915	c.910G>T	c.(910-912)GAG>TAG	p.E304*	CTNNA2_uc010yse.1_Nonsense_Mutation_p.E304*|CTNNA2_uc010ysf.1_Nonsense_Mutation_p.E304*|CTNNA2_uc010ysg.1_Nonsense_Mutation_p.E304*	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	304					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GCCGTCCCTGGAGGAGAGGCT	0.592													60	107					5.41189e-41	7.67904e-41	1	0	T	80136777	T	T	80136777	4	4	5	1	0	0	0	0	0	1	0	0	4030	1175	41	2		2	CTNNA2	2	80136777	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	788014	80136777	163062596	53	1189											
TMEM150A	129303	broad.mit.edu	37	chr2	85829067	85829067	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caggcaggaggatccaggcgGtcatgagggaggggagccag	10	3	20	8	1	1	1	1	1	0	0	2	5	2	5	2	8	1	1	2	8	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:85829067G>T	uc002spw.1	-	1	726	c.5C>A	c.(4-6)ACC>AAC	p.T2N	USP39_uc002sqb.2_5'Flank|TMEM150A_uc002spx.1_5'UTR|TMEM150A_uc002spz.1_5'UTR|TMEM150A_uc002sqa.1_5'UTR|TMEM150A_uc002spy.1_Missense_Mutation_p.T2N	NM_001031738	NP_001026908	Q86TG1	T150A_HUMAN	transmembrane protein 150A isoform 1	2						integral to membrane|plasma membrane					0						GATCCAGGCGGTCATGAGGGA	0.612													168	257					1.85097e-90	2.85113e-90	1	0	T	85829067	T	T	85829067	3	4	5	1	0	0	0	0	1	0	0	0	16133	1261	44	4	838	4	TMEM150A	2	85829067	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	5692290	85829067	157370306	54	1190											
AFF3	3899	broad.mit.edu	37	chr2	100625330	100625330	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacgtgccatcatcctgttGagtttcttgatttcttcttt	7	19	6	9	1	4	2	1	2	3	0	5	2	5	2	2	0	2	2	2	0	1	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:100625330G>T	uc002tag.2	-	4	354	c.118C>A	c.(118-120)CAA>AAA	p.Q40K	AFF3_uc002taf.2_Missense_Mutation_p.Q65K|AFF3_uc010fiq.1_Missense_Mutation_p.Q40K|AFF3_uc010yvr.1_Missense_Mutation_p.Q194K|AFF3_uc002tah.1_Missense_Mutation_p.Q65K|AFF3_uc010fir.1_Missense_Mutation_p.Q117K|AFF3_uc002tai.2_5'Flank	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	40					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TCATCCTGTTGAGTTTCTTGA	0.403													18	26					3.32936e-07	3.5252e-07	1	0	T	100625330	T	T	100625330	3	4	5	1	0	0	0	0	1	0	0	0	358	1299	45	2	3646	2	AFF3	2	100625330	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	14796263	100625330	142574043	55	1191											
RGPD3	653489	broad.mit.edu	37	chr2	107042508	107042508	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgggaattatatgctggtGactgactataatatactgaa	14	13	9	5	0	0	3	0	3	0	0	0	4	0	4	0	2	2	1	0	2	8	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:107042508G>T	uc010ywi.1	-	19	2699	c.2642C>A	c.(2641-2643)TCA>TAA	p.S881*		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	881					intracellular transport		binding			ovary(1)	1						ATATGCTGGTGACTGACTATA	0.308													38	153					1.32667e-27	1.70225e-27	1	0	T	107042508	T	T	107042508	4	4	5	1	0	0	0	0	0	1	0	0	13352	1294	45	2	2654	2	RGPD3	2	107042508	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	6417178	107042508	136156865	56	1192											
PCDP1	200373	broad.mit.edu	37	chr2	120413946	120413946	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttgatactcagagaagtgaAagatcaagcacaaccagcag	17	7	9	8	0	2	4	2	2	0	2	2	5	2	4	1	0	4	2	1	0	5	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:120413946A>G	uc002tmb.2	+	25	2657	c.1565A>G	c.(1564-1566)AAA>AGA	p.K522R		NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	808						cilium	calmodulin binding				0	Colorectal(110;0.196)					AGAGAAGTGAAAGATCAAGCA	0.498													30	47					0	0	0	0	G	120413946	G	G	120413946	3	3	5	1	0	0	0	0	1	0	0	0	11626	14	1	5	1627	5	PCDP1	2	120413946	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	13371438	120413946	122785427	57	1193											
ARHGEF4	50649	broad.mit.edu	37	chr2	131797883	131797883	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacatgttcagcgaggagcAgctgcgtaccatcttcggga	10	8	13	10	3	2	1	1	0	1	1	3	4	2	3	1	2	5	4	1	2	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:131797883A>T	uc002tsa.1	+	8	1494	c.974A>T	c.(973-975)CAG>CTG	p.Q325L	ARHGEF4_uc010fmw.1_Intron|ARHGEF4_uc002tsb.1_Missense_Mutation_p.Q325L|ARHGEF4_uc010fmx.1_Intron|ARHGEF4_uc002tsc.1_5'UTR	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	325	DH.				apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		AGCGAGGAGCAGCTGCGTACC	0.667													14	24					0	0	0	0	T	131797883	T	T	131797883	3	4	5	1	0	0	0	0	1	0	0	0	908	188	7	5	996	5	ARHGEF4	2	131797883	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	11383937	131797883	111401490	58	1194											
RAB3GAP1	22930	broad.mit.edu	37	chr2	135878405	135878405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagggatgtcctttaactcCattgcctccagttagtattg	8	15	8	10	0	0	0	0	0	0	0	3	1	3	1	4	1	2	2	4	1	4	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:135878405C>T	uc002tuj.2	+	8	690	c.665C>T	c.(664-666)CCA>CTA	p.P222L	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.P222L|RAB3GAP1_uc010fng.2_Missense_Mutation_p.P47L|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	222						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		CCTTTAACTCCATTGCCTCCA	0.378													93	138					0	0	0	0	T	135878405	T	T	135878405	3	4	5	1	0	0	0	0	1	0	0	0	13000	594	21	4	695	4	RAB3GAP1	2	135878405	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4080522	135878405	107320968	59	1195											
LRP1B	53353	broad.mit.edu	37	chr2	141460022	141460022	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtcgatggagatgccattcgGccatgctattcccatgctta	8	12	10	11	2	0	1	0	0	0	1	3	3	1	1	3	2	3	2	3	2	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:141460022G>A	uc002tvj.1	-	38	7096	c.6124C>T	c.(6124-6126)CCG>TCG	p.P2042S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2042	Extracellular (Potential).|LDL-receptor class B 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGCCATTCGGCCATGCTATT	0.433										TSP Lung(27;0.18)			49	111					0	0	0	0	A	141460022	A	A	141460022	3	1	5	1	0	0	0	0	1	0	0	0	9005	1203	42	4	7891	4	LRP1B	2	141460022	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	5581617	141460022	101739351	60	1196											
ZEB2	9839	broad.mit.edu	37	chr2	145147422	145147422	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctccgcctcccgcttgcAgtaggaatacctgtgattca	7	11	8	15	2	1	1	1	1	0	0	4	2	4	2	5	1	2	3	5	1	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:145147422A>G	uc002tvu.2	-	10	3721	c.3241T>C	c.(3241-3243)TGC>CGC	p.C1081R	ZEB2_uc002tvv.2_Missense_Mutation_p.C1075R|ZEB2_uc010zbm.1_Missense_Mutation_p.C1052R|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	1081						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCCCGCTTGCAGTAGGAATAC	0.602													47	73					0	0	0	0	G	145147422	G	G	145147422	3	3	5	1	0	0	0	0	1	0	0	0	17691	188	7	5	407	5	ZEB2	2	145147422	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	3687400	145147422	98051951	61	1197											
MBD5	55777	broad.mit.edu	37	chr2	149240960	149240960	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgaatcaacagcatctcCtaaaccagaatctattaaat	17	10	4	10	0	3	2	1	1	2	1	4	2	3	2	2	0	3	1	2	0	8	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:149240960C>G	uc002twm.3	+	10	3788	c.2800C>G	c.(2800-2802)CTA>GTA	p.L934V	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.L934V|MBD5_uc002two.2_5'Flank|MBD5_uc002twp.2_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	934						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ACAGCATCTCCTAAACCAGAA	0.468													116	219					0	0	0	0	G	149240960	G	G	149240960	3	3	5	1	0	0	0	0	1	0	0	0	9400	680	24	4	2818	4	MBD5	2	149240960	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4093538	149240960	93958413	62	1198											
TBR1	10716	broad.mit.edu	37	chr2	162273105	162273105	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaccagggggatgacgaatCagtcagatacagacaatttt	14	10	10	7	1	2	3	2	1	0	2	2	5	2	4	1	2	2	0	1	2	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:162273105C>G	uc002ubw.1	+	1	486	c.184C>G	c.(184-186)CAG>GAG	p.Q62E	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	62						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GATGACGAATCAGTCAGATAC	0.493													66	91					0	0	0	0	G	162273105	G	G	162273105	3	3	5	1	0	0	0	0	1	0	0	0	15713	827	29	2	186	2	TBR1	2	162273105	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	13032145	162273105	80926268	63	1199											
LRP2	4036	broad.mit.edu	37	chr2	170062967	170062967	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcatagtctagagacatGacagttctttccacatttat	11	15	6	9	0	3	2	1	1	2	1	4	3	4	2	1	0	0	1	1	0	3	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:170062967G>A	uc002ues.2	-	39	7476	c.7263C>T	c.(7261-7263)GTC>GTT	p.V2421V		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2421	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTAGAGACATGACAGTTCTTT	0.413													71	96					0	0	0	0	A	170062967	A	A	170062967	2	1	5	1	0	0	0	0	0	0	0	1	9006	1277	45	2		2	LRP2	2	170062967	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	7789862	170062967	73136406	64	1200											
HOXD8	3234	broad.mit.edu	37	chr2	176995440	176995440	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccctcctcctccgcatcctCcgcctccgccgccacctccc	2	7	4	28	4	0	0	0	0	0	0	7	0	7	0	13	0	0	1	13	0	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:176995440C>A	uc002uko.2	+	1	964	c.346C>A	c.(346-348)CCG>ACG	p.P116T	uc002ukl.1_5'Flank|uc002ukm.1_5'Flank|HOXD8_uc002ukn.2_Intron|HOXD8_uc002ukp.2_Missense_Mutation_p.P116T	NM_019558	NP_062458	P13378	HXD8_HUMAN	homeobox D8	116	Poly-Pro.				anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		tccgcatcctccgcctccgcc	0.507													77	90					2.36143e-25	2.96355e-25	1	0	A	176995440	A	A	176995440	3	1	5	1	0	0	0	0	1	0	0	0	7364	855	30	2	348	2	HOXD8	2	176995440	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	6932473	176995440	66203933	65	1201											
HOXD4	3233	broad.mit.edu	37	chr2	177016671	177016671	+	Frame_Shift_Del	DEL	C	-	-																															cagctcccccggcgcctccgCcggcgcccctgcctggcgcc																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:177016671delC	uc002uks.2	+	1	559	c.310delC	c.(310-312)CCGfs	p.P104fs		NM_014621	NP_055436	P09016	HXD4_HUMAN	homeobox D4	104						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		ggcgcctccgccggcgcccct	0.562													---	---	---								-	177016671	-	-	177016671	7	5	5	1	0	1	0	1	0	0	0	0	7363	739	26	0	312	0	HOXD4	2	177016671	Frame_Shift_Del	DEL	C	TCGA-BA-4078-01A-01D-1434-08	21231	177016671	66182702	66	1202											
TTN	7273	broad.mit.edu	37	chr2	179427269	179427269	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tactcttccaggtgggagggGtggttcagacactttaacgg	8	11	14	8	1	2	1	1	0	1	1	3	2	3	2	1	6	2	1	1	6	2	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:179427269G>A	uc010zfg.1	-	275	76110	c.75886C>T	c.(75886-75888)CCC>TCC	p.P25296S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P18991S|TTN_uc010zfi.1_Missense_Mutation_p.P18924S|TTN_uc010zfj.1_Missense_Mutation_p.P18799S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26223							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGGGAGGGGTGGTTCAGAC	0.448													52	76					0	0	0	0	A	179427269	A	A	179427269	3	1	5	1	0	0	0	0	1	0	0	0	16803	1261	44	4	24537	4	TTN	2	179427269	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2410598	179427269	63772104	67	1203											
TTN	7273	broad.mit.edu	37	chr2	179470333	179470333	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acgccgtttttcaatgatatAtccttggatgggactgccac	9	13	9	10	2	1	1	1	1	0	0	2	3	2	3	3	2	1	1	3	2	3	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:179470333A>G	uc010zfg.1	-	228	46209	c.45985T>C	c.(45985-45987)TAT>CAT	p.Y15329H	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Y9024H|TTN_uc010zfi.1_Missense_Mutation_p.Y8957H|TTN_uc010zfj.1_Missense_Mutation_p.Y8832H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16256							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAATGATATATCCTTGGATG	0.443													76	133					0	0	0	0	G	179470333	G	G	179470333	3	3	5	1	0	0	0	0	1	0	0	0	16803	449	16	5	54340	5	TTN	2	179470333	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	43064	179470333	63729040	68	1204											
TTN	7273	broad.mit.edu	37	chr2	179583155	179583155	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctcaagaatttccagtatGgtagatttttctgtcatagt	10	17	7	7	0	3	2	2	0	2	2	5	2	4	2	1	1	0	2	1	1	5	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:179583155G>T	uc010zfg.1	-	82	21170	c.20946C>A	c.(20944-20946)ACC>ACA	p.T6982T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T3643T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7909							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCCAGTATGGTAGATTTTT	0.418													49	62					2.13384e-23	2.63076e-23	1	0	T	179583155	T	T	179583155	2	4	5	1	0	0	0	0	0	0	0	1	16803	1335	47	4		4	TTN	2	179583155	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	112822	179583155	63616218	69	1205											
ZSWIM2	151112	broad.mit.edu	37	chr2	187703843	187703844	+	Frame_Shift_Ins	INS	-	C	C																															ggagtttgaactcgatgtatINScccccgaagcaagtcactta																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:187703843_187703844insC	uc002upu.1	-	4	376_377	c.336_337insG	c.(334-339)GGGATAfs	p.G112fs		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	112_113					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			ACTCGATGTATCCCCCGAAGCA	0.391													---	---	---								C	187703844	C	C	187703843	7	5	5	1	0	1	1	0	0	0	0	0	18308	1435	50	0	1588	0	ZSWIM2	2	187703843	Frame_Shift_Ins	INS	-	TCGA-BA-4078-01A-01D-1434-08	8120688	187703843	55495530	70	1206											
C2orf88	84281	broad.mit.edu	37	chr2	191064816	191064816	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgatgccttgcagcaatGggcatgcaataacatcaagt	12	10	11	8	0	1	1	1	1	0	0	1	1	1	1	1	1	5	4	1	1	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:191064816G>A	uc002urq.2	+	3	609	c.230G>A	c.(229-231)TGG>TAG	p.W77*	C2orf88_uc002urr.2_Nonsense_Mutation_p.W77*|C2orf88_uc002urs.2_Nonsense_Mutation_p.W77*|C2orf88_uc002urt.2_Nonsense_Mutation_p.W77*	NM_001042521	NP_001035986	Q9BSF0	CB088_HUMAN	hypothetical protein LOC84281	77											0						TTGCAGCAATGGGCATGCAAT	0.473													130	204					0	0	0	0	A	191064816	A	A	191064816	4	1	5	1	0	0	0	0	0	1	0	0	2212	1357	47	4	232	4	C2orf88	2	191064816	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3360973	191064816	52134557	71	1207											
DNAH7	56171	broad.mit.edu	37	chr2	196659124	196659124	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccatgaggtatgatcgaaTgatattagcccgtaaacctt	12	12	9	8	2	0	3	0	3	0	0	2	4	1	3	3	1	2	2	3	1	6	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:196659124T>A	uc002utj.3	-	57	10755	c.10654A>T	c.(10654-10656)ATT>TTT	p.I3552F	DNAH7_uc002uti.3_Missense_Mutation_p.I35F	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3552	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TATGATCGAATGATATTAGCC	0.453													71	95					0	0	0	0	A	196659124	A	A	196659124	3	1	5	1	0	0	0	0	1	0	0	0	4628	1464	51	5	1456	5	DNAH7	2	196659124	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	5594308	196659124	46540249	72	1208											
MOBKL3	25843	broad.mit.edu	37	chr2	198413136	198413136	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagcaataaatattttcccaGcaggtaatcgaaacttttaa	16	13	5	7	1	0	0	0	0	0	0	2	1	1	0	1	1	3	3	1	1	8	8			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:198413136G>T	uc002uun.3	+	6	471	c.431G>T	c.(430-432)AGC>ATC	p.S144I	MOBKL3_uc002uum.3_Missense_Mutation_p.S112I|MOBKL3_uc010fsn.2_Missense_Mutation_p.S123I|MOBKL3_uc010fso.2_Missense_Mutation_p.S45I|MOBKL3_uc010zgz.1_Missense_Mutation_p.S45I	NM_015387	NP_056202	Q9Y3A3	MOBL3_HUMAN	Mps One Binder kinase activator-like 3 isoform	144					transport	Golgi cisterna membrane|perinuclear region of cytoplasm	metal ion binding|protein binding				0			Epithelial(96;0.225)			TATTTTCCCAGCAGGTAATCG	0.249													49	78					2.81731e-22	3.41985e-22	1	0	T	198413136	T	T	198413136	3	4	5	1	0	0	0	0	1	0	0	0	9740	971	34	4	453	4	MOBKL3	2	198413136	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1754012	198413136	44786237	73	1209											
ERBB4	2066	broad.mit.edu	37	chr2	212288906	212288906	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccatgaccatgtaaacgtcaAtagtgcagatgggaggctga	13	8	12	8	1	1	3	1	2	0	1	1	4	1	4	2	2	2	3	2	2	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:212288906A>G	uc002veg.1	-	23	2938	c.2840T>C	c.(2839-2841)ATT>ACT	p.I947T	ERBB4_uc002veh.1_Missense_Mutation_p.I947T|ERBB4_uc010zji.1_Missense_Mutation_p.I937T|ERBB4_uc010zjj.1_Missense_Mutation_p.I937T	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	947	Protein kinase.|Cytoplasmic (Potential).			I->R: Constitutively autophosphorylated.	cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTAAACGTCAATAGTGCAGAT	0.388										TSP Lung(8;0.080)			70	105					0	0	0	0	G	212288906	G	G	212288906	3	3	5	1	0	0	0	0	1	0	0	0	5233	101	4	5	1110	5	ERBB4	2	212288906	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	13875770	212288906	30910467	74	1210											
CTDSP1	58190	broad.mit.edu	37	chr2	219267845	219267845	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgttcactgctagcctcGccaaggtgagccccacaggg	7	8	12	14	1	1	1	1	1	0	0	2	1	1	1	4	2	4	3	4	2	2	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:219267845G>A	uc002vhy.2	+	5	802	c.466G>A	c.(466-468)GCC>ACC	p.A156T	CTDSP1_uc002vhx.2_Missense_Mutation_p.A155T|CTDSP1_uc002vhz.2_Missense_Mutation_p.A15T	NM_021198	NP_067021	Q9GZU7	CTDS1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	156	FCP1 homology.				protein dephosphorylation|regulation of transcription from RNA polymerase II promoter	nucleus	CTD phosphatase activity|metal ion binding|protein binding			ovary(1)	1		Renal(207;0.0915)		Epithelial(149;9.96e-07)|all cancers(144;0.00017)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGCTAGCCTCGCCAAGGTGAG	0.642													51	73					0	0	0	0	A	219267845	A	A	219267845	3	1	5	1	0	0	0	0	1	0	0	0	4020	1087	38	1	484	1	CTDSP1	2	219267845	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	6978939	219267845	23931528	75	1211											
WDFY1	57590	broad.mit.edu	37	chr2	224765920	224765920	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagacacgaagcccaggaCgtgaagaagtgcctcccgag	12	4	13	12	3	0	3	0	1	0	2	1	6	1	4	3	1	3	1	3	1	3	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:224765920C>T	uc002vnq.2	-	5	516	c.465G>A	c.(463-465)ACG>ACA	p.T155T		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	155	WD 4.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		AAGCCCAGGACGTGAAGAAGT	0.577													50	75					0	0	0	0	T	224765920	T	T	224765920	2	4	5	1	0	0	0	0	0	0	0	1	17336	523	19	1		1	WDFY1	2	224765920	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5498075	224765920	18433453	76	1212											
DOCK10	55619	broad.mit.edu	37	chr2	225659685	225659685	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agtgcttgcgtaggagtttgCcaggctgtactggagatcca	8	11	14	8	1	0	1	0	0	0	1	1	3	1	2	2	3	4	5	2	3	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:225659685C>T	uc010fwz.1	-	45	5304	c.5065G>A	c.(5065-5067)GCA>ACA	p.A1689T	DOCK10_uc002vob.2_Missense_Mutation_p.A1683T|DOCK10_uc002voa.2_Missense_Mutation_p.A345T|DOCK10_uc002voc.2_Missense_Mutation_p.A543T	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1689	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TAGGAGTTTGCCAGGCTGTAC	0.517													5	275					0	0	0	0	T	225659685	T	T	225659685	3	4	5	1	0	0	0	0	1	0	0	0	4707	739	26	4	1543	4	DOCK10	2	225659685	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	893765	225659685	17539688	77	1213											
COL4A4	1286	broad.mit.edu	37	chr2	227985813	227985813	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgaaagcccaatgggtcctgGggctcccaggggtccaattg	8	8	14	11	0	0	1	0	1	0	0	3	1	3	1	4	5	1	1	4	5	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:227985813G>A	uc010zlt.1	-	5	898	c.244C>T	c.(244-246)CCA>TCA	p.P82S		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	82	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ATGGGTCCTGGGGCTCCCAGG	0.542													59	72					0	0	0	0	A	227985813	A	A	227985813	3	1	5	1	0	0	0	0	1	0	0	0	3708	1232	43	4	5004	4	COL4A4	2	227985813	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2326128	227985813	15213560	78	1214											
DIS3L2	129563	broad.mit.edu	37	chr2	233198642	233198642	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtacacacacttcacctcGcccatccgccgctttgccga	7	9	6	19	4	1	0	1	0	0	0	3	1	2	0	5	0	2	2	5	0	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:233198642G>A	uc010fxz.2	+	17	2379	c.2103G>A	c.(2101-2103)TCG>TCA	p.S701S	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA|DIS3L2_uc002vsp.1_5'Flank	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	701							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		ACTTCACCTCGCCCATCCGCC	0.667													58	97					0	0	0	0	A	233198642	A	A	233198642	2	1	5	1	0	0	0	0	0	0	0	1	4559	1074	38	1		1	DIS3L2	2	233198642	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	5212829	233198642	10000731	79	1215											
CHRND	1144	broad.mit.edu	37	chr2	233394727	233394727	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctctggacagccccagccGccaggacatcaccttctacc	8	6	7	20	1	3	0	1	0	2	0	3	2	3	2	7	2	3	0	7	2	1	2	rs146416320		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:233394727G>T	uc002vsw.2	+	7	702	c.698G>T	c.(697-699)CGC>CTC	p.R233L	CHRND_uc010zmg.1_Missense_Mutation_p.R218L|CHRND_uc010fyc.2_Missense_Mutation_p.R106L|CHRND_uc010zmh.1_Intron	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	233	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		AGCCCCAGCCGCCAGGACATC	0.617													56	103					4.32865e-36	5.95426e-36	1	0	T	233394727	T	T	233394727	3	4	5	1	0	0	0	0	1	0	0	0	3409	1087	38	3	724	3	CHRND	2	233394727	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	196085	233394727	9804646	80	1216											
NGEF	25791	broad.mit.edu	37	chr2	233839522	233839522	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcaggtttcaccttggctgGttcattatcagtgttccatt	6	17	8	10	0	4	0	4	0	0	0	5	0	5	0	2	3	0	4	2	3	1	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:233839522G>T	uc002vts.2	-	2	327	c.79C>A	c.(79-81)CCA>ACA	p.P27T		NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	27	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		ACCTTGGCTGGTTCATTATCA	0.443													81	125					1.51875e-23	1.87979e-23	1	0	T	233839522	T	T	233839522	3	4	5	1	0	0	0	0	1	0	0	0	10448	1261	44	4	2220	4	NGEF	2	233839522	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	444795	233839522	9359851	81	1217											
TRPM8	79054	broad.mit.edu	37	chr2	234904971	234904971	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctctcttccctcaccagcTacacggtgggcaccgtccag	6	10	8	17	2	3	0	1	0	2	0	6	0	5	0	4	2	2	2	4	2	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:234904971T>G	uc002vvh.2	+	22	2981	c.2941T>G	c.(2941-2943)TAC>GAC	p.Y981D	TRPM8_uc010fyj.2_Missense_Mutation_p.Y559D|TRPM8_uc010fyk.2_RNA	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	981	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CCTCACCAGCTACACGGTGGG	0.512													45	74					0	0	0	0	G	234904971	G	G	234904971	3	3	5	1	0	0	0	0	1	0	0	0	16659	1536	53	5	3023	5	TRPM8	2	234904971	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	1065449	234904971	8294402	82	1218											
COL6A3	1293	broad.mit.edu	37	chr2	238275541	238275541	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cccctctgggtgagggccagGctcacatcctgtgcatcttc	5	10	11	15	0	3	1	1	1	2	0	5	1	4	1	4	3	1	2	4	3	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:238275541G>T	uc002vwl.2	-	11	5574	c.5289C>A	c.(5287-5289)AGC>AGA	p.S1763R	COL6A3_uc002vwo.2_Missense_Mutation_p.S1557R|COL6A3_uc010znj.1_Missense_Mutation_p.S1156R	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1763	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGAGGGCCAGGCTCACATCCT	0.582													48	56					2.43468e-25	3.0494e-25	1	0	T	238275541	T	T	238275541	3	4	5	1	0	0	0	0	1	0	0	0	3716	1194	42	4	4380	4	COL6A3	2	238275541	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3370570	238275541	4923832	83	1219											
COL6A3	1293	broad.mit.edu	37	chr2	238283363	238283363	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttctgttatcctgcttcccGcagagctgaccaggatgttc	6	13	9	13	1	1	2	0	1	1	1	4	3	3	3	3	1	2	5	3	1	1	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:238283363G>C	uc002vwl.2	-	8	3656	c.3371C>G	c.(3370-3372)GCG>GGG	p.A1124G	COL6A3_uc002vwo.2_Missense_Mutation_p.A918G|COL6A3_uc010znj.1_Missense_Mutation_p.A517G|COL6A3_uc002vwq.2_Missense_Mutation_p.A918G|COL6A3_uc002vwr.2_Missense_Mutation_p.A717G	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1124	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCTGCTTCCCGCAGAGCTGAC	0.647													45	68					0	0	0	0	C	238283363	C	C	238283363	3	2	5	1	0	0	0	0	1	0	0	0	3716	1087	38	3	6357	3	COL6A3	2	238283363	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	7822	238283363	4916010	84	1220											
CAPN10	11132	broad.mit.edu	37	chr2	241533429	241533429	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgcggatccagaacccctgGggccggcggtgctggcaggg	5	5	18	13	3	0	1	0	0	0	1	1	2	1	2	4	7	3	2	4	7	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr2:241533429G>T	uc002vzk.1	+	5	979	c.795G>T	c.(793-795)TGG>TGT	p.W265C	CAPN10_uc010zoh.1_Missense_Mutation_p.W265C|CAPN10_uc002vzl.1_Missense_Mutation_p.W265C|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Missense_Mutation_p.W137C|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	265	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		AGAACCCCTGGGGCCGGCGGT	0.692													86	106					1.42954e-44	2.07514e-44	1	0	T	241533429	T	T	241533429	3	4	5	1	0	0	0	0	1	0	0	0	2635	1241	43	4	813	4	CAPN10	2	241533429	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3250066	241533429	1665944	85	1221											
LRRN1	57633	broad.mit.edu	37	chr3	3886403	3886403	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcattaaccgagtcttcCatacagaatagtgagtgtcc	12	12	7	10	1	2	2	1	1	1	1	4	3	4	2	3	0	2	0	3	0	4	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:3886403C>A	uc003bpt.3	+	2	839	c.78C>A	c.(76-78)TCC>TCA	p.S26S	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	26	LRRNT.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CCGAGTCTTCCATACAGAATA	0.463													59	19					4.10029e-35	5.57923e-35	1	0	A	3886403	A	A	3886403	2	1	5	1	0	0	0	0	0	0	0	1	9084	581	21	4		4	LRRN1	3	3886403	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08		3886403	194136027	86	1222											
PLCL2	23228	broad.mit.edu	37	chr3	17056221	17056221	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgcggtggtgtcattcaagGagctgtgtggcctctcctct	5	13	13	10	1	4	0	2	0	2	0	5	1	4	1	2	4	2	1	2	4	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:17056221G>A	uc011awc.1	+	6	2917	c.2812G>A	c.(2812-2814)GAG>AAG	p.E938K	PLCL2_uc011awd.1_Missense_Mutation_p.E820K	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	946					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GTCATTCAAGGAGCTGTGTGG	0.463													173	43					0	0	0	0	A	17056221	A	A	17056221	3	1	5	1	0	0	0	0	1	0	0	0	12095	1175	41	2	2840	2	PLCL2	3	17056221	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	13169818	17056221	180966209	87	1223											
EOMES	8320	broad.mit.edu	37	chr3	27763724	27763724	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcctcgcgcactctccagcGggtagaagtgcgcgccaggc	6	5	14	16	6	1	1	0	0	1	1	3	1	1	1	3	2	2	2	3	2	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:27763724G>T	uc003cdx.2	-	1	62	c.62C>A	c.(61-63)CCG>CAG	p.P21Q	EOMES_uc003cdy.3_Missense_Mutation_p.P21Q|EOMES_uc010hfn.2_Missense_Mutation_p.P21Q|EOMES_uc011axc.1_Intron	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	21					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						ACTCTCCAGCGGGTAGAAGTG	0.642													6	2					0.00198382	0.00202234	1	0	T	27763724	T	T	27763724	3	4	5	1	0	0	0	0	1	0	0	0	5171	1116	39	3	2022	3	EOMES	3	27763724	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	10707503	27763724	170258706	88	1224											
ANO10	55129	broad.mit.edu	37	chr3	43474181	43474181	+	Frame_Shift_Del	DEL	G	-	-																															tgccgtggcttatcaggtatGgcaaatgcaagtataaactt																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:43474181delG	uc003cmv.2	-	12	2007	c.1836delC	c.(1834-1836)GCCfs	p.A612fs	ANO10_uc011azs.1_Intron|ANO10_uc003cmw.2_Frame_Shift_Del_p.A546fs|ANO10_uc010hil.2_Frame_Shift_Del_p.A422fs|ANO10_uc011azt.1_Frame_Shift_Del_p.A501fs	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	612	Cytoplasmic (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						TATCAGGTATGGCAAATGCAA	0.423													---	---	---								-	43474181	-	-	43474181	7	5	5	1	0	1	0	1	0	0	0	0	696	1335	47	0	154	0	ANO10	3	43474181	Frame_Shift_Del	DEL	G	TCGA-BA-4078-01A-01D-1434-08	15710457	43474181	154548249	89	1225											
LAMB2	3913	broad.mit.edu	37	chr3	49161040	49161040	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctcgagctgagtcaggtgCtcagtggcctccccaatttc	6	10	11	14	1	2	1	2	1	0	0	5	2	3	1	4	2	2	2	4	2	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:49161040C>T	uc003cwe.2	-	25	4121	c.3822G>A	c.(3820-3822)GAG>GAA	p.E1274E	USP19_uc003cvz.3_5'Flank|USP19_uc011bcg.1_5'Flank|USP19_uc003cwb.2_5'Flank|USP19_uc003cwd.1_5'Flank|USP19_uc011bch.1_5'Flank|USP19_uc011bci.1_5'Flank	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1274	Domain II.|Potential.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GAGTCAGGTGCTCAGTGGCCT	0.557													69	25					0	0	0	0	T	49161040	T	T	49161040	2	4	5	1	0	0	0	0	0	0	0	1	8651	796	28	4		4	LAMB2	3	49161040	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5686859	49161040	148861390	90	1226											
AMIGO3	386724	broad.mit.edu	37	chr3	49755619	49755619	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggactgtgcgctcagctctTggagcgggctgggtgtttgg	4	11	18	8	2	2	0	1	0	1	0	2	2	2	2	0	5	3	4	0	5	0	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:49755619T>G	uc003cxj.2	-	1	1620	c.1280A>C	c.(1279-1281)CAA>CCA	p.Q427P	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	427	Cytoplasmic (Potential).				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCTCAGCTCTTGGAGCGGGCT	0.522													74	27					0	0	0	0	G	49755619	G	G	49755619	3	3	5	1	0	0	0	0	1	0	0	0	577	1812	63	5	238	5	AMIGO3	3	49755619	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	594579	49755619	148266811	91	1227											
CACNA2D2	9254	broad.mit.edu	37	chr3	50421637	50421637	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcacactcacagcctttgtaGatgtccgtagggatctgtac	9	11	10	11	1	2	1	1	0	1	1	3	2	3	2	2	1	2	4	2	1	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:50421637G>A	uc003daq.2	-	6	680	c.642C>T	c.(640-642)ATC>ATT	p.I214I	CACNA2D2_uc003dap.2_Silent_p.I214I	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	214	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	AGCCTTTGTAGATGTCCGTAG	0.567													219	70					0	0	0	0	A	50421637	A	A	50421637	2	1	5	1	0	0	0	0	0	0	0	1	2561	932	33	2		2	CACNA2D2	3	50421637	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	666018	50421637	147600793	92	1228											
FOXP1	27086	broad.mit.edu	37	chr3	71247394	71247394	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggcgaggtcagctgcccCgatgtccacggccggcgtct	4	7	16	14	5	2	0	1	0	1	0	3	2	3	0	4	4	2	1	4	4	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:71247394C>A	uc003dol.2	-	2	462	c.139G>T	c.(139-141)GGG>TGG	p.G47W	FOXP1_uc003dom.2_Missense_Mutation_p.G47W|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Missense_Mutation_p.G47W|FOXP1_uc003dop.2_Missense_Mutation_p.G47W|FOXP1_uc003doq.1_Missense_Mutation_p.G47W|FOXP1_uc003dos.2_Missense_Mutation_p.G47W	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	47					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		TCAGCTGCCCCGATGTCCACG	0.627			T	PAX5	ALL								85	38					5.00163e-47	7.37946e-47	1	0	A	71247394	A	A	71247394	3	1	5	1	0	0	0	0	1	0	0	0	6060	652	23	3	2127	3	FOXP1	3	71247394	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	20825757	71247394	126775036	93	1229											
PDZRN3	23024	broad.mit.edu	37	chr3	73433465	73433465	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcgctcgagctgtccttgTcggatttctccgggagctcg	4	11	14	12	5	1	0	0	0	1	0	6	3	2	2	2	3	2	3	2	3	0	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:73433465T>C	uc003dpl.1	-	10	2348	c.2252A>G	c.(2251-2253)GAC>GGC	p.D751G	PDZRN3_uc011bgh.1_Missense_Mutation_p.D408G|PDZRN3_uc010hoe.1_Missense_Mutation_p.D449G|PDZRN3_uc011bgf.1_Missense_Mutation_p.D468G|PDZRN3_uc011bgg.1_Missense_Mutation_p.D471G	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	751							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GCTGTCCTTGTCGGATTTCTC	0.617													26	12					0	0	0	0	C	73433465	C	C	73433465	3	2	5	1	0	0	0	0	1	0	0	0	11763	1667	58	5	952	5	PDZRN3	3	73433465	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	2186071	73433465	124588965	94	1230											
ROBO2	6092	broad.mit.edu	37	chr3	77666777	77666777	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccaacacctcctgttcgagGcgtggcttcttctcctgcta	5	12	8	16	2	2	0	0	0	2	0	5	1	3	0	4	2	2	3	4	2	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:77666777G>A	uc003dpy.3	+	22	4050	c.3407G>A	c.(3406-3408)GGC>GAC	p.G1136D	ROBO2_uc003dpz.2_Missense_Mutation_p.G1140D|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.G1140D|ROBO2_uc003dqa.2_Missense_Mutation_p.G263D	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1136	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CCTGTTCGAGGCGTGGCTTCT	0.527													85	21					0	0	0	0	A	77666777	A	A	77666777	3	1	5	1	0	0	0	0	1	0	0	0	13579	1203	42	4	3495	4	ROBO2	3	77666777	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	4233312	77666777	120355653	95	1231											
EPHA3	2042	broad.mit.edu	37	chr3	89521722	89521722	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactgcaaggaaatcttcacGggtgtggagtacagttcttg	10	11	12	8	1	3	0	1	0	2	0	3	2	3	2	0	3	2	3	0	3	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:89521722G>T	uc003dqy.2	+	16	3024	c.2799G>T	c.(2797-2799)ACG>ACT	p.T933T	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	933	Cytoplasmic (Potential).|SAM.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		AAATCTTCACGGGTGTGGAGT	0.413										TSP Lung(6;0.00050)			60	28					1.32218e-49	1.95993e-49	1	0	T	89521722	T	T	89521722	2	4	5	1	0	0	0	0	0	0	0	1	5192	1103	39	3		3	EPHA3	3	89521722	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	11854945	89521722	108500708	96	1232											
NSUN3	63899	broad.mit.edu	37	chr3	93783304	93783304	+	Missense_Mutation	SNP	G	T	T																															aaagcaaaatcagaggggaaGcttgcaaaacagatttgcaa																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:93783304G>T	uc003drl.1	+	2	152	c.36G>T	c.(34-36)AAG>AAT	p.K12N	DHFRL1_uc003dri.2_5'Flank|DHFRL1_uc003drj.2_5'Flank	NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	NOL1/NOP2/Sun domain family, member 3	12							methyltransferase activity			skin(1)	1						CAGAGGGGAAGCTTGCAAAAC	0.358													30	105					2.81731e-10	3.06547e-10	1	0	T	93783304	T	T	93783304	3	4	5	1	0	0	0	0	1	0	0	0	10733	962	34	4	42	4	NSUN3	3	93783304	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	4261582	93783304	104239126	97	1233	4	2									
NSUN3	63899	broad.mit.edu	37	chr3	93783306	93783306	+	Missense_Mutation	SNP	T	A	A																															agcaaaatcagaggggaagcTtgcaaaacagatttgcaaag																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:93783306T>A	uc003drl.1	+	2	154	c.38T>A	c.(37-39)CTT>CAT	p.L13H	DHFRL1_uc003dri.2_5'Flank|DHFRL1_uc003drj.2_5'Flank	NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	NOL1/NOP2/Sun domain family, member 3	13							methyltransferase activity			skin(1)	1						GAGGGGAAGCTTGCAAAACAG	0.363													30	104					0	0	0	0	A	93783306	A	A	93783306	3	1	5	1	0	0	0	0	1	0	0	0	10733	1609	56	5	44	5	NSUN3	3	93783306	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	2	93783306	104239124	98	1234	4	2									
EPHA6	285220	broad.mit.edu	37	chr3	96706794	96706794	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggttcctcttggaaggtgCatctgcagtacaggatatga	9	12	12	8	0	2	1	0	1	2	0	3	3	3	3	1	4	3	4	1	4	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:96706794C>T	uc010how.1	+	3	1114	c.1071C>T	c.(1069-1071)TGC>TGT	p.C357C	EPHA6_uc003drp.1_Silent_p.C357C	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	262	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TTGGAAGGTGCATCTGCAGTA	0.383													57	207					0	0	0	0	T	96706794	T	T	96706794	2	4	5	1	0	0	0	0	0	0	0	1	5195	718	25	4		4	EPHA6	3	96706794	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2923488	96706794	101315636	99	1235											
FILIP1L	11259	broad.mit.edu	37	chr3	99567165	99567165	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgtgattgtcgaggaagagGtgtggctgttggtgtgatag	7	14	18	2	1	0	3	0	2	0	1	1	5	0	4	0	4	0	2	0	4	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:99567165G>A	uc003dtm.2	-	5	3818	c.3355C>T	c.(3355-3357)CCT>TCT	p.P1119S	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Missense_Mutation_p.P1119S|FILIP1L_uc010hpf.2_Missense_Mutation_p.P695S|FILIP1L_uc010hpg.2_Missense_Mutation_p.P879S|FILIP1L_uc003dtn.2_Missense_Mutation_p.P879S|FILIP1L_uc003dtp.1_Missense_Mutation_p.P879S	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	1119						cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						CGAGGAAGAGGTGTGGCTGTT	0.413													75	258					0	0	0	0	A	99567165	A	A	99567165	3	1	5	1	0	0	0	0	1	0	0	0	5927	1261	44	4	81	4	FILIP1L	3	99567165	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2860371	99567165	98455265	100	1236											
GPR128	84873	broad.mit.edu	37	chr3	100349615	100349615	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aatcccagtgggcagatatgGaccatccttgcaaacatgtg	12	9	10	10	0	0	1	0	0	0	1	2	2	2	2	3	2	2	2	3	2	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:100349615G>T	uc003duc.2	+	3	564	c.296G>T	c.(295-297)GGA>GTA	p.G99V		NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	99	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						GGCAGATATGGACCATCCTTG	0.348													88	107					5.34484e-38	7.41685e-38	1	0	T	100349615	T	T	100349615	3	4	5	1	0	0	0	0	1	0	0	0	6679	1174	41	2	306	2	GPR128	3	100349615	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	782450	100349615	97672815	101	1237											
GPR128	84873	broad.mit.edu	37	chr3	100373869	100373869	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acaccattaacatcccgaatCccatgtgcactgcgattgcc	11	9	6	15	2	0	0	0	0	0	0	2	2	2	0	4	0	4	1	4	0	2	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:100373869C>A	uc003duc.2	+	12	1838	c.1570C>A	c.(1570-1572)CCC>ACC	p.P524T	GPR128_uc011bhc.1_Missense_Mutation_p.P225T|GPR128_uc003dud.2_Missense_Mutation_p.P47T	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	524	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						CATCCCGAATCCCATGTGCAC	0.423													286	380					2.29708e-82	3.52966e-82	1	0	A	100373869	A	A	100373869	3	1	5	1	0	0	0	0	1	0	0	0	6679	855	30	2	1616	2	GPR128	3	100373869	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	24254	100373869	97648561	102	1238											
CEP97	79598	broad.mit.edu	37	chr3	101477063	101477063	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agcaacttcagagaaacttcCcatgattttaacccagagat	15	10	6	10	0	1	3	1	1	0	2	2	5	2	3	2	0	4	1	2	0	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:101477063C>G	uc003dvk.1	+	9	1640	c.1613C>G	c.(1612-1614)CCC>CGC	p.P538R	CEP97_uc010hpm.1_Missense_Mutation_p.P504R|CEP97_uc011bhf.1_Missense_Mutation_p.P479R|CEP97_uc003dvl.1_Missense_Mutation_p.P234R|CEP97_uc003dvm.1_Missense_Mutation_p.P376R	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	538	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						GAGAAACTTCCCATGATTTTA	0.418													90	349					0	0	0	0	G	101477063	G	G	101477063	3	3	5	1	0	0	0	0	1	0	0	0	3278	623	22	4	1647	4	CEP97	3	101477063	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1103194	101477063	96545367	103	1239											
MYH15	22989	broad.mit.edu	37	chr3	108159997	108159997	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagctcagaatttatctcCtcttcttcctccaccctctc	6	15	3	17	0	6	1	2	0	4	1	10	1	8	1	4	0	1	1	4	0	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:108159997C>T	uc003dxa.1	-	24	2883	c.2826G>A	c.(2824-2826)GAG>GAA	p.E942E		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	942	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						AATTTATCTCCTCTTCTTCCT	0.478													83	256					0	0	0	0	T	108159997	T	T	108159997	2	4	5	1	0	0	0	0	0	0	0	1	10087	680	24	4		4	MYH15	3	108159997	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	6682934	108159997	89862433	104	1240											
PLSCR5	389158	broad.mit.edu	37	chr3	146309588	146309588	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcttctttgtttgcattttgGattgtgaatttaggcagaaa	9	19	9	4	0	2	2	0	1	2	1	2	3	2	3	0	2	1	3	0	2	3	8			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:146309588G>T	uc003ewb.2	-	5	1538	c.534C>A	c.(532-534)ATC>ATA	p.I178I	PLSCR5_uc010hvb.2_Silent_p.I166I|PLSCR5_uc010hvc.2_Silent_p.I178I	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	178											0						TTGCATTTTGGATTGTGAATT	0.388													61	26					2.22609e-26	2.81049e-26	1	0	T	146309588	T	T	146309588	2	4	5	1	0	0	0	0	0	0	0	1	12168	1164	41	2		2	PLSCR5	3	146309588	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	38149591	146309588	51712842	105	1241											
ZIC1	7545	broad.mit.edu	37	chr3	147128064	147128064	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcaaccccagttcgcacgaGctggcttcggccggccagac	7	6	11	17	4	1	1	1	0	0	1	3	2	1	1	4	3	2	4	4	3	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:147128064G>C	uc003ewe.2	+	1	884	c.165G>C	c.(163-165)GAG>GAC	p.E55D		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	55					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTTCGCACGAGCTGGCTTCGG	0.711													89	50					0	0	0	0	C	147128064	C	C	147128064	3	2	5	1	0	0	0	0	1	0	0	0	17745	962	34	4	167	4	ZIC1	3	147128064	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	818476	147128064	50894366	106	1242											
FAM194A	131831	broad.mit.edu	37	chr3	150400034	150400034	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttcagaggaaacatccaCattagaaaaaaatgctctta	17	10	7	7	0	2	2	1	0	1	2	3	3	3	3	1	2	2	2	1	2	6	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:150400034C>A	uc003eyg.2	-	7	910	c.853G>T	c.(853-855)GTG>TTG	p.V285L	FAM194A_uc003eyh.2_Missense_Mutation_p.V139L	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	285										skin(2)|ovary(1)	3						GAAACATCCACATTAGAAAAA	0.358													88	123					2.01383e-38	2.81936e-38	1	0	A	150400034	A	A	150400034	3	1	5	1	0	0	0	0	1	0	0	0	5554	478	17	4	1170	4	FAM194A	3	150400034	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3271970	150400034	47622396	107	1243											
GPR149	344758	broad.mit.edu	37	chr3	154146445	154146445	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatgggcagccaaaggacGacttttgtaagcgctaggat	12	9	12	8	2	1	0	1	0	0	0	1	3	1	2	1	3	2	3	1	3	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:154146445G>T	uc003faa.2	-	1	1060	c.960C>A	c.(958-960)GTC>GTA	p.V320V		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	320	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GCCAAAGGACGACTTTTGTAA	0.567													229	311					4.76836e-124	7.39918e-124	1	0	T	154146445	T	T	154146445	2	4	5	1	0	0	0	0	0	0	0	1	6692	1045	37	3		3	GPR149	3	154146445	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3746411	154146445	43875985	108	1244											
SI	6476	broad.mit.edu	37	chr3	164786619	164786619	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgtttaatttggcttcaactCcttaaagaataaaaaaaagc	17	13	5	6	0	1	1	1	0	0	1	2	1	2	1	1	1	2	2	1	1	9	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:164786619C>G	uc003fei.2	-	5	436	c.374G>C	c.(373-375)GGA>GCA	p.G125A		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	125	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GGCTTCAACTCCTTAAAGAAT	0.303										HNSCC(35;0.089)			5	253					0	0	0	0	G	164786619	G	G	164786619	3	3	5	1	0	0	0	0	1	0	0	0	14362	869	30	2	5285	2	SI	3	164786619	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	10640174	164786619	33235811	109	1245											
PDCD10	11235	broad.mit.edu	37	chr3	167437849	167437849	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaacatgtttacccaactcaCctcattaaacacaggataca	16	9	4	12	0	2	0	2	0	0	0	2	2	2	1	2	1	5	1	2	1	6	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:167437849C>T	uc003fex.2	-	3	494	c.96_splice	c.e3+1	p.E32_splice	PDCD10_uc003fez.2_Splice_Site_p.E32_splice|PDCD10_uc003fey.2_Splice_Site_p.E32_splice	NM_007217	NP_009148	Q9BUL8	PDC10_HUMAN	programmed cell death 10						angiogenesis|apoptosis|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of MAP kinase activity	cytosol|Golgi membrane|plasma membrane	protein homodimerization activity|protein N-terminus binding			lung(1)|central_nervous_system(1)	2						ACCCAACTCACCTCATTAAAC	0.343									Familial_Cerebral_Cavernous_Angioma				57	208					0	0	0	0	T	167437849	T	T	167437849	5	4	5	1	0	0	0	0	0	0	1	0	11670	521	18	4	569	4	PDCD10	3	167437849	Splice_Site	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2651230	167437849	30584581	110	1246											
USP13	8975	broad.mit.edu	37	chr3	179472519	179472519	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataatctctctcattttgcaGatgtttctattgatatgcca	10	18	5	8	0	3	2	1	1	3	1	5	2	3	2	1	0	2	2	1	0	3	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:179472519G>T	uc003fkh.2	+	15	1880	c.1799_splice	c.e15-1	p.D600_splice	USP13_uc003fkf.2_Intron	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13						ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TCATTTTGCAGATGTTTCTAT	0.448													89	293					1.54307e-61	2.34816e-61	1	0	T	179472519	T	T	179472519	5	4	5	1	0	0	0	0	0	0	1	0	17112	956	33	2	1856	2	USP13	3	179472519	Splice_Site	SNP	G	TCGA-BA-4078-01A-01D-1434-08	12034670	179472519	18549911	111	1247											
VPS8	23355	broad.mit.edu	37	chr3	184675175	184675175	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttttagggaaggtattcatGtaaatcaagaattactgcaa	15	14	8	4	0	2	1	2	0	0	1	2	2	2	2	0	2	2	3	0	2	9	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:184675175G>T	uc003fpb.1	+	36	3214	c.3043G>T	c.(3043-3045)GTA>TTA	p.V1015L	VPS8_uc010hyd.1_Missense_Mutation_p.V925L|VPS8_uc010hye.1_Missense_Mutation_p.V444L	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1017							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			AGGTATTCATGTAAATCAAGA	0.333													9	60					3.09899e-07	3.29235e-07	1	0	T	184675175	T	T	184675175	3	4	5	1	0	0	0	0	1	0	0	0	17286	1377	48	4	3187	4	VPS8	3	184675175	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	5202656	184675175	13347255	112	1248											
CCDC50	152137	broad.mit.edu	37	chr3	191078925	191078925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctattgaggcagagagacgaCgcattcaggagaagaaggat	15	6	14	6	2	1	5	1	1	0	4	1	9	1	6	0	3	0	2	0	3	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:191078925C>T	uc003fsw.2	+	4	897	c.307C>T	c.(307-309)CGC>TGC	p.R103C	CCDC50_uc003fsv.2_Missense_Mutation_p.R103C	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	103	Potential.					cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		AGAGAGACGACGCATTCAGGA	0.433													31	171					0	0	0	0	T	191078925	T	T	191078925	3	4	5	1	0	0	0	0	1	0	0	0	2833	536	19	1	321	1	CCDC50	3	191078925	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	6403750	191078925	6943505	113	1249											
CPN2	1370	broad.mit.edu	37	chr3	194063363	194063363	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgaagcagtcacaacccatGggacagggctgggcaggcct	11	4	14	12	1	1	0	1	0	0	0	1	2	1	1	2	4	2	3	2	4	2	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:194063363G>T	uc003fts.2	-	2	159	c.69C>A	c.(67-69)CCC>CCA	p.P23P		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	23	LRRNT.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		CACAACCCATGGGACAGGGCT	0.582													237	88					6.35764e-115	9.84106e-115	1	0	T	194063363	T	T	194063363	2	4	5	1	0	0	0	0	0	0	0	1	3825	1335	47	4		4	CPN2	3	194063363	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2984438	194063363	3959067	114	1250											
UBXN7	26043	broad.mit.edu	37	chr3	196098827	196098827	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcgttgctccacacatcGcggttgaggcactgacatgc	7	10	11	13	3	0	2	0	2	0	0	3	2	1	2	1	2	2	5	1	2	0	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr3:196098827G>A	uc003fwm.3	-	6	630	c.555C>T	c.(553-555)CGC>CGT	p.R185R	UBXN7_uc003fwn.3_Silent_p.R37R|UBXN7_uc010iae.2_Silent_p.R23R	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	185							protein binding			ovary(2)|pancreas(1)	3						TCCACACATCGCGGTTGAGGC	0.413													91	333					0	0	0	0	A	196098827	A	A	196098827	2	1	5	1	0	0	0	0	0	0	0	1	16986	1074	38	1		1	UBXN7	3	196098827	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2035464	196098827	1923603	115	1251											
SLIT2	9353	broad.mit.edu	37	chr4	20543121	20543121	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgtaactgctacctggcttgGttgggagagtggctgagaaa	9	11	15	6	0	0	2	0	1	0	2	0	4	0	2	1	4	3	5	1	4	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:20543121G>T	uc003gpr.1	+	20	2226	c.2022G>T	c.(2020-2022)TGG>TGT	p.W674C	SLIT2_uc003gps.1_Missense_Mutation_p.W666C	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	674	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ACCTGGCTTGGTTGGGAGAGT	0.458													46	11					1.10885e-35	1.52195e-35	1	0	T	20543121	T	T	20543121	3	4	5	1	0	0	0	0	1	0	0	0	14804	1270	44	4	2100	4	SLIT2	4	20543121	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08		20543121	170611155	116	1252											
SLIT2	9353	broad.mit.edu	37	chr4	20555507	20555507	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgaagtcggaatataaggagCctggaattgctcgttgtgct	10	12	13	6	2	0	1	0	1	0	0	2	4	0	4	1	3	3	3	1	3	5	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:20555507C>T	uc003gpr.1	+	26	2845	c.2641C>T	c.(2641-2643)CCT>TCT	p.P881S	SLIT2_uc003gps.1_Missense_Mutation_p.P873S	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	881	LRRCT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ATATAAGGAGCCTGGAATTGC	0.428													98	12					0	0	0	0	T	20555507	T	T	20555507	3	4	5	1	0	0	0	0	1	0	0	0	14804	739	26	4	2743	4	SLIT2	4	20555507	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	12386	20555507	170598769	117	1253											
GABRA2	2555	broad.mit.edu	37	chr4	46252334	46252334	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggtctcaattcaaggactGacccctaatacaggttctct	10	12	8	11	0	3	1	2	1	2	0	5	2	3	2	2	3	1	1	2	3	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:46252334G>A	uc003gxc.3	-	9	2020	c.1347C>T	c.(1345-1347)GTC>GTT	p.V449V	GABRA2_uc010igc.2_Silent_p.V449V|GABRA2_uc011bzc.1_Silent_p.V454V	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	449					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTCAAGGACTGACCCCTAATA	0.338													70	23					0	0	0	0	A	46252334	A	A	46252334	2	1	5	1	0	0	0	0	0	0	0	1	6195	1277	45	2		2	GABRA2	4	46252334	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	25696827	46252334	144901942	118	1254											
GABRA4	2557	broad.mit.edu	37	chr4	46930523	46930523	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctttcgaggcatatatcCagttcggatagaagtaggag	12	10	12	7	2	0	1	0	0	0	1	3	4	1	3	2	3	1	3	2	3	5	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:46930523C>G	uc003gxg.2	-	9	1523	c.1384G>C	c.(1384-1386)GGA>CGA	p.G462R		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	462	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GGCATATATCCAGTTCGGATA	0.473													68	18					0	0	0	0	G	46930523	G	G	46930523	3	3	5	1	0	0	0	0	1	0	0	0	6197	603	21	4	284	4	GABRA4	4	46930523	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	678189	46930523	144223753	119	1255											
UGT2B7	7364	broad.mit.edu	37	chr4	69978432	69978432	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggaagtttgctagaaaagCaaagaagggaaaaaatgatt	19	8	11	3	0	0	3	0	1	0	2	0	5	0	5	0	2	2	3	0	2	9	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:69978432C>A	uc003heg.3	+	6	1614	c.1568C>A	c.(1567-1569)GCA>GAA	p.A523E	UGT2B7_uc010ihq.2_3'UTR	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	523					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GCTAGAAAAGCAAAGAAGGGA	0.378													48	25					1.67211e-32	2.21774e-32	1	0	A	69978432	A	A	69978432	3	1	5	1	0	0	0	0	1	0	0	0	17030	710	25	4	1590	4	UGT2B7	4	69978432	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	23047909	69978432	121175844	120	1256											
UGT2B4	7363	broad.mit.edu	37	chr4	70352383	70352383	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtattgagtcctaaagtaTctggtttattcccatcaaat	12	15	7	7	0	2	1	1	1	1	0	4	2	4	1	2	1	0	3	2	1	6	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:70352383T>A	uc003hek.3	-	4	1081	c.1034A>T	c.(1033-1035)GAT>GTT	p.D345V	UGT2B4_uc011cap.1_Missense_Mutation_p.D209V|UGT2B4_uc003hel.3_Missense_Mutation_p.D345V	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	345					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TCCTAAAGTATCTGGTTTATT	0.348													102	40					0	0	0	0	A	70352383	A	A	70352383	3	1	5	1	0	0	0	0	1	0	0	0	17029	1435	50	5	564	5	UGT2B4	4	70352383	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	373951	70352383	120801893	121	1257											
KIAA1109	84162	broad.mit.edu	37	chr4	123207877	123207877	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcggatcaggtgtggagtatAgatgaactgccttctaaaca	12	11	11	7	1	2	2	1	1	1	1	3	4	2	4	1	3	3	1	1	3	5	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:123207877A>G	uc003ieh.2	+	51	9264	c.9219A>G	c.(9217-9219)ATA>ATG	p.I3073M	KIAA1109_uc003iel.1_Missense_Mutation_p.I1008M	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3073					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TGTGGAGTATAGATGAACTGC	0.378													66	23					0	0	0	0	G	123207877	G	G	123207877	3	3	5	1	0	0	0	0	1	0	0	0	8247	410	15	5	9421	5	KIAA1109	4	123207877	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	52855494	123207877	67946399	122	1258											
SPATA5	166378	broad.mit.edu	37	chr4	123868598	123868598	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagctggcaaatagtgctCatggatacgttggagcagac	11	9	13	8	1	1	1	1	0	0	1	1	3	1	3	0	3	5	6	0	3	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:123868598C>T	uc003iez.3	+	9	1742	c.1669C>T	c.(1669-1671)CAT>TAT	p.H557Y	SPATA5_uc003iey.2_Missense_Mutation_p.H556Y	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	557					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						AAATAGTGCTCATGGATACGT	0.478													70	26					0	0	0	0	T	123868598	T	T	123868598	3	4	5	1	0	0	0	0	1	0	0	0	15077	826	29	2	1703	2	SPATA5	4	123868598	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	660721	123868598	67285678	123	1259											
FGA	2243	broad.mit.edu	37	chr4	155507095	155507095	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccagacaatgtgcctaaatCcattgcctcgggacagtcag	11	8	10	12	1	1	1	1	0	0	1	3	2	2	2	4	1	2	0	4	1	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:155507095C>A	uc003iod.1	-	5	1544	c.1486G>T	c.(1486-1488)GAT>TAT	p.D496Y	FGA_uc003ioe.1_Missense_Mutation_p.D496Y|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	496	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GTGCCTAAATCCATTGCCTCG	0.473													87	33					9.37156e-40	1.31788e-39	1	0	A	155507095	A	A	155507095	3	1	5	1	0	0	0	0	1	0	0	0	5862	855	30	2	1166	2	FGA	4	155507095	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	31638497	155507095	35647181	124	1260											
GUCY1A3	2982	broad.mit.edu	37	chr4	156632328	156632328	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcaaccagacgtttagcggGatcatgactatgttgaatat	13	12	9	7	2	2	3	2	2	0	1	2	4	2	4	1	1	2	2	1	1	5	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:156632328G>T	uc003iov.2	+	7	1547	c.1011G>T	c.(1009-1011)GGG>GGT	p.G337G	GUCY1A3_uc003iou.2_Silent_p.G337G|GUCY1A3_uc010iqc.2_Silent_p.G337G|GUCY1A3_uc003iow.2_Silent_p.G337G|GUCY1A3_uc010iqd.2_Silent_p.G336G|GUCY1A3_uc003iox.2_Silent_p.G337G|GUCY1A3_uc003ioz.2_Silent_p.G102G|GUCY1A3_uc003ioy.2_Silent_p.G337G|GUCY1A3_uc010iqe.2_Silent_p.G102G|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Silent_p.G337G	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	337					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CGTTTAGCGGGATCATGACTA	0.383													73	30					2.93416e-43	4.21075e-43	1	0	T	156632328	T	T	156632328	2	4	5	1	0	0	0	0	0	0	0	1	6933	1161	41	2		2	GUCY1A3	4	156632328	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1125233	156632328	34521948	125	1261											
ACCN5	51802	broad.mit.edu	37	chr4	156752976	156752976	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaattaaataacacttacCaagtaactcagacacactca	19	8	3	11	0	2	1	2	0	0	1	2	1	2	1	1	0	4	2	1	0	7	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:156752976C>A	uc003ipe.1	-	9	1374	c.1327G>T	c.(1327-1329)GCA>TCA	p.A443S		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	443	Extracellular (Potential).			A->F,T: Activates the channel.|A->C: Slightly activates the channel.		integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		TAACACTTACCAAGTAACTCA	0.224													54	26					2.69774e-35	3.68672e-35	1	0	A	156752976	A	A	156752976	3	1	5	1	0	0	0	0	1	0	0	0	132	608	21	4	198	4	ACCN5	4	156752976	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	120648	156752976	34401300	126	1262											
ACCN5	51802	broad.mit.edu	37	chr4	156764923	156764923	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcaccttctttggtgaatgGataacaaagatgatcccagc	12	10	10	9	0	1	3	0	2	1	1	2	4	2	4	2	3	2	1	2	3	3	3	rs145138118	by1000genomes	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:156764923G>C	uc003ipe.1	-	5	818	c.771C>G	c.(769-771)ATC>ATG	p.I257M		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	257	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		TTGGTGAATGGATAACAAAGA	0.443													43	19					0	0	0	0	C	156764923	C	C	156764923	3	2	5	1	0	0	0	0	1	0	0	0	132	1164	41	2	770	2	ACCN5	4	156764923	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	11947	156764923	34389353	127	1263											
GRIA2	2891	broad.mit.edu	37	chr4	158262467	158262467	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtggttctttaccctgatCataatctcctcctacacggc	7	14	7	13	1	3	1	1	1	2	0	5	1	4	1	3	3	2	1	3	3	3	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:158262467C>T	uc003ipm.3	+	12	2355	c.1896C>T	c.(1894-1896)ATC>ATT	p.I632I	GRIA2_uc011cit.1_Silent_p.I585I|GRIA2_uc003ipl.3_Silent_p.I632I|GRIA2_uc003ipk.3_Silent_p.I585I|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	632	Helical; (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TTACCCTGATCATAATCTCCT	0.433													154	58					0	0	0	0	T	158262467	T	T	158262467	2	4	5	1	0	0	0	0	0	0	0	1	6807	816	29	2		2	GRIA2	4	158262467	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1497544	158262467	32891809	128	1264											
ADAM29	11086	broad.mit.edu	37	chr4	175896743	175896743	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctggacacatccaggatGagcacccccaatatcacagc	12	7	8	14	0	2	1	1	1	1	0	3	3	3	3	3	2	2	2	3	2	2	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:175896743G>T	uc003iuc.2	+	5	737	c.67G>T	c.(67-69)GAG>TAG	p.E23*	ADAM29_uc003iud.2_Nonsense_Mutation_p.E23*|ADAM29_uc010irr.2_Nonsense_Mutation_p.E23*|ADAM29_uc011cki.1_Nonsense_Mutation_p.E23*	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	23					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CATCCAGGATGAGCACCCCCA	0.498													63	20					7.55815e-43	1.07974e-42	1	0	T	175896743	T	T	175896743	4	4	5	1	0	0	0	0	0	1	0	0	247	1291	45	2	69	2	ADAM29	4	175896743	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	17634276	175896743	15257533	129	1265											
FAT1	2195	broad.mit.edu	37	chr4	187630465	187630465	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctatgtctgcatccgtggCgctgactcttgcgatactgg	5	13	11	12	3	2	1	0	1	2	0	4	2	4	1	2	2	3	2	2	2	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:187630465C>G	uc003izf.2	-	2	705	c.517G>C	c.(517-519)GCC>CCC	p.A173P	FAT1_uc010iso.1_Missense_Mutation_p.A173P	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	173	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCATCCGTGGCGCTGACTCTT	0.438										HNSCC(5;0.00058)			137	35					0	0	0	0	G	187630465	G	G	187630465	3	3	5	1	0	0	0	0	1	0	0	0	5721	768	27	3	13353	3	FAT1	4	187630465	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	11733722	187630465	3523811	130	1266											
ZFP42	132625	broad.mit.edu	37	chr4	188924029	188924029	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggtggaagagcccccaGtggggctaagcccaggcaag	9	4	16	12	0	0	1	0	0	0	1	0	2	0	2	4	5	2	2	4	5	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr4:188924029G>T	uc003izg.1	+	3	313	c.68G>T	c.(67-69)AGT>ATT	p.S23I	ZFP42_uc003izh.1_Missense_Mutation_p.S23I|ZFP42_uc003izi.1_Missense_Mutation_p.S23I	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	23					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AGAGCCCCCAGTGGGGCTAAG	0.547													50	15					3.21987e-24	4.00102e-24	1	0	T	188924029	T	T	188924029	3	4	5	1	0	0	0	0	1	0	0	0	17717	1029	36	4	70	4	ZFP42	4	188924029	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1293564	188924029	2230247	131	1267											
SEMA5A	9037	broad.mit.edu	37	chr5	9052125	9052125	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactcagaccagtccgacCactccgaccagctctctgca	10	6	6	19	2	2	1	1	0	1	1	5	3	4	1	5	0	2	2	5	0	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:9052125C>T	uc003jek.2	-	20	3417	c.2705G>A	c.(2704-2706)TGG>TAG	p.W902*		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	902	Extracellular (Potential).|TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CCAGTCCGACCACTCCGACCA	0.587													16	46					0	0	0	0	T	9052125	T	T	9052125	4	4	5	1	0	0	0	0	0	1	0	0	14102	595	21	4	535	4	SEMA5A	5	9052125	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08		9052125	171863135	132	1268											
CTNND2	1501	broad.mit.edu	37	chr5	11346684	11346684	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggcggcattctgtgggccGtgctggctgcctgtgcgctg	1	10	18	12	4	1	0	0	0	1	0	1	0	1	0	2	4	3	4	2	4	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:11346684G>T	uc003jfa.1	-	9	1573	c.1428C>A	c.(1426-1428)CAC>CAA	p.H476Q	CTNND2_uc010itt.2_Missense_Mutation_p.H385Q|CTNND2_uc011cmy.1_Missense_Mutation_p.H139Q|CTNND2_uc011cmz.1_Missense_Mutation_p.H43Q|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.H43Q	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	476					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TCTGTGGGCCGTGCTGGCTGC	0.617													46	98					3.68427e-32	4.86601e-32	1	0	T	11346684	T	T	11346684	3	4	5	1	0	0	0	0	1	0	0	0	4037	1136	40	3	2305	3	CTNND2	5	11346684	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2294559	11346684	169568576	133	1269											
DNAH5	1767	broad.mit.edu	37	chr5	13752361	13752361	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagagaaaggctgtcttccAggtggtttctgaagtacttg	10	12	12	7	0	2	2	0	1	2	1	3	3	3	2	1	3	1	3	1	3	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:13752361A>G	uc003jfd.2	-	64	10952	c.10910T>C	c.(10909-10911)CTG>CCG	p.L3637P	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3637	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCTGTCTTCCAGGTGGTTTCT	0.403									Kartagener_syndrome				69	147					0	0	0	0	G	13752361	G	G	13752361	3	3	5	1	0	0	0	0	1	0	0	0	4626	188	7	5	3028	5	DNAH5	5	13752361	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	2405677	13752361	167162899	134	1270											
DNAH5	1767	broad.mit.edu	37	chr5	13841950	13841950	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacattgccctctgccatgaCaggtttatccaattcaatcg	10	12	6	13	1	2	1	1	1	1	0	4	1	3	1	3	1	2	1	3	1	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:13841950C>G	uc003jfd.2	-	33	5377	c.5335G>C	c.(5335-5337)GTC>CTC	p.V1779L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1779	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTGCCATGACAGGTTTATCC	0.383									Kartagener_syndrome				49	183					0	0	0	0	G	13841950	G	G	13841950	3	3	5	1	0	0	0	0	1	0	0	0	4626	478	17	4	8727	4	DNAH5	5	13841950	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	89589	13841950	167073310	135	1271											
DNAH5	1767	broad.mit.edu	37	chr5	13894843	13894843	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagccaggttggagagcttCatccactttggccaagtgag	10	9	12	10	0	1	2	1	1	0	1	2	3	2	2	3	3	2	2	3	3	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:13894843C>A	uc003jfd.2	-	16	2389	c.2347G>T	c.(2347-2349)GAA>TAA	p.E783*		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	783	Potential.|Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGGAGAGCTTCATCCACTTTG	0.423									Kartagener_syndrome				98	209					9.47431e-33	1.25924e-32	1	0	A	13894843	A	A	13894843	4	1	5	1	0	0	0	0	0	1	0	0	4626	835	29	2	11783	2	DNAH5	5	13894843	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	52893	13894843	167020417	136	1272											
FBXL7	23194	broad.mit.edu	37	chr5	15936859	15936859	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cggcctgcgggagatcgccaAgctggagtcccgcctgcggt	5	6	16	14	5	0	1	0	0	0	1	2	3	1	2	4	4	3	1	4	4	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:15936859A>T	uc003jfn.1	+	4	1521	c.1040A>T	c.(1039-1041)AAG>ATG	p.K347M		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	347	LRR 7.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						GAGATCGCCAAGCTGGAGTCC	0.657													22	12					0	0	0	0	T	15936859	T	T	15936859	3	4	5	1	0	0	0	0	1	0	0	0	5756	72	3	5	1054	5	FBXL7	5	15936859	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	2042016	15936859	164978401	137	1273											
PRDM9	56979	broad.mit.edu	37	chr5	23526959	23526959	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctgcagggagtgtgggcggGgctttagctggcagtcagtc	5	10	18	8	1	2	0	1	0	1	0	3	1	2	1	0	5	2	4	0	5	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:23526959G>C	uc003jgo.2	+	11	1944	c.1762G>C	c.(1762-1764)GGC>CGC	p.G588R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	588	C2H2-type 4.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GTGTGGGCGGGGCTTTAGCTG	0.607										HNSCC(3;0.000094)			46	157					0	0	0	0	C	23526959	C	C	23526959	3	2	5	1	0	0	0	0	1	0	0	0	12525	1232	43	4	1800	4	PRDM9	5	23526959	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	7590100	23526959	157388301	138	1274											
CDH10	1008	broad.mit.edu	37	chr5	24505268	24505268	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgccactgagatagttcaCggtcaagaggttttgatgta	11	13	11	6	1	2	3	2	2	0	2	2	4	2	3	1	2	1	3	1	2	4	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:24505268C>A	uc003jgr.1	-	8	1678	c.1346G>T	c.(1345-1347)CGT>CTT	p.R449L	CDH10_uc011cnu.1_Intron	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	449	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AGATAGTTCACGGTCAAGAGG	0.328										HNSCC(23;0.051)			31	105					4.02929e-09	4.32445e-09	1	0	A	24505268	A	A	24505268	3	1	5	1	0	0	0	0	1	0	0	0	3111	536	19	3	1040	3	CDH10	5	24505268	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	978309	24505268	156409992	139	1275											
PDZD2	23037	broad.mit.edu	37	chr5	31983279	31983279	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agttacctggctgagcagtgCtggaatggcggctttatcta	8	12	13	8	1	1	1	0	1	1	0	1	2	1	2	1	4	3	5	1	4	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:31983279C>T	uc003jhl.2	+	3	883	c.495C>T	c.(493-495)TGC>TGT	p.C165C	PDZD2_uc003jhm.2_Silent_p.C165C|PDZD2_uc011cnx.1_5'UTR	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	165	PDZ 1.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CTGAGCAGTGCTGGAATGGCG	0.527													49	151					0	0	0	0	T	31983279	T	T	31983279	2	4	5	1	0	0	0	0	0	0	0	1	11755	805	28	4		4	PDZD2	5	31983279	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	7478011	31983279	148931981	140	1276											
ZFR	51663	broad.mit.edu	37	chr5	32420208	32420208	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acacccgaagctggctgctgGctacattgtggagtacaaga	11	8	12	10	1	0	1	0	0	0	1	0	3	0	2	1	3	4	5	1	3	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:32420208G>T	uc003jhr.1	-	3	218	c.138C>A	c.(136-138)AGC>AGA	p.S46R	ZFR_uc010iun.1_Missense_Mutation_p.S46R	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	46	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		CTGGCTGCTGGCTACATTGTG	0.398													10	33					2.17888e-05	2.26144e-05	1	0	T	32420208	T	T	32420208	3	4	5	1	0	0	0	0	1	0	0	0	17726	1217	42	4	3158	4	ZFR	5	32420208	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	436929	32420208	148495052	141	1277											
ADAMTS12	81792	broad.mit.edu	37	chr5	33588885	33588885	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggggcccgcatgtcgccGagcatgcttcccactcccct	4	8	11	18	4	0	0	0	0	0	0	3	1	2	0	5	2	2	3	5	2	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:33588885G>T	uc003jia.1	-	18	2847	c.2684C>A	c.(2683-2685)TCG>TAG	p.S895*	ADAMTS12_uc010iuq.1_Nonsense_Mutation_p.S810*	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	895	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GCATGTCGCCGAGCATGCTTC	0.582										HNSCC(64;0.19)	OREG0016553	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	115					5.34276e-22	6.42354e-22	1	0	T	33588885	T	T	33588885	4	4	5	1	0	0	0	0	0	1	0	0	257	1059	37	3	2128	3	ADAMTS12	5	33588885	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1168677	33588885	147326375	142	1278											
NIPBL	25836	broad.mit.edu	37	chr5	37064663	37064663	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaacgaaattcagactctaCggagttggcagcacagatga	16	7	10	8	2	2	3	1	1	1	2	2	5	2	4	0	2	3	3	0	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:37064663C>T	uc003jkl.3	+	47	8583	c.8084C>T	c.(8083-8085)ACG>ATG	p.T2695M	NIPBL_uc003jkk.3_3'UTR|NIPBL_uc003jkn.2_3'UTR	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2695					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TCAGACTCTACGGAGTTGGCA	0.393													107	240					0	0	0	0	T	37064663	T	T	37064663	3	4	5	1	0	0	0	0	1	0	0	0	10482	536	19	1	8311	1	NIPBL	5	37064663	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3475778	37064663	143850597	143	1279											
C5orf34	375444	broad.mit.edu	37	chr5	43502545	43502545	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccccttctgatttgaaaaCagatccatccccagaataaa	15	9	5	12	0	1	4	0	2	1	2	3	4	3	4	5	0	2	0	5	0	5	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:43502545C>A	uc003jnz.1	-	7	1398	c.1081G>T	c.(1081-1083)GTT>TTT	p.V361F		NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	361										breast(1)	1	Lung NSC(6;2.07e-05)					GATTTGAAAACAGATCCATCC	0.308													74	204					1.74474e-33	2.33373e-33	1	0	A	43502545	A	A	43502545	3	1	5	1	0	0	0	0	1	0	0	0	2303	478	17	4	867	4	C5orf34	5	43502545	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	6437882	43502545	137412715	144	1280											
PARP8	79668	broad.mit.edu	37	chr5	50128662	50128662	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaaggacgagccagcttcaAgcagtaaaagcagcaataca	17	4	9	11	1	1	0	1	0	0	0	1	2	1	1	2	1	6	5	2	1	6	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:50128662A>G	uc003jon.3	+	24	2463	c.2281A>G	c.(2281-2283)AGC>GGC	p.S761G	PARP8_uc011cpz.1_Missense_Mutation_p.S653G|PARP8_uc003joo.2_Missense_Mutation_p.S761G|PARP8_uc003jop.2_Missense_Mutation_p.S719G	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	761	PARP catalytic.					intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GCCAGCTTCAAGCAGTAAAAG	0.438													30	8					0	0	0	0	G	50128662	G	G	50128662	3	3	5	1	0	0	0	0	1	0	0	0	11519	72	3	5	2371	5	PARP8	5	50128662	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	6626117	50128662	130786598	145	1281											
GPR98	84059	broad.mit.edu	37	chr5	89938711	89938711	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctccacatcatccgatcaagGgggtcccttgttaagcagtt	9	11	9	12	1	2	0	2	0	0	0	5	1	5	0	3	2	1	3	3	2	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:89938711G>T	uc003kju.2	+	13	2502	c.2406G>T	c.(2404-2406)AGG>AGT	p.R802S	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	802	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCCGATCAAGGGGGTCCCTTG	0.403													92	25					1.04318e-46	1.53552e-46	1	0	T	89938711	T	T	89938711	3	4	5	1	0	0	0	0	1	0	0	0	6760	1223	43	4	2456	4	GPR98	5	89938711	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	39810049	89938711	90976549	146	1282											
CHSY3	337876	broad.mit.edu	37	chr5	129520379	129520379	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatgccaagagcagaggacGgctcattgacttcaaggaaa	15	6	12	8	1	2	3	2	1	0	2	2	6	2	5	1	3	2	2	1	3	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:129520379G>T	uc003kvd.2	+	3	1544	c.1544G>T	c.(1543-1545)CGG>CTG	p.R515L		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	515	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		AGCAGAGGACGGCTCATTGAC	0.468													36	12					1.58521e-26	2.00538e-26	1	0	T	129520379	T	T	129520379	3	4	5	1	0	0	0	0	1	0	0	0	3428	1116	39	3	1554	3	CHSY3	5	129520379	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	39581668	129520379	51394881	147	1283											
PCDHGA3	56112	broad.mit.edu	37	chr5	140723683	140723683	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gacgctgtgcgaaacaggatCcggtcagatccgctactcgg	9	7	13	12	5	1	1	1	0	0	1	4	4	3	2	2	3	3	2	2	3	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:140723683C>G	uc003ljm.1	+	1	83	c.83C>G	c.(82-84)TCC>TGC	p.S28C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Translation_Start_Site|PCDHGA3_uc011dap.1_Missense_Mutation_p.S28C	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	28					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAACAGGATCCGGTCAGATC	0.587											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	194	70					0	0	0	0	G	140723683	G	G	140723683	3	3	5	1	0	0	0	0	1	0	0	0	11609	855	30	2	85	2	PCDHGA3	5	140723683	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	11203304	140723683	40191577	148	1284											
FAT2	2196	broad.mit.edu	37	chr5	150924598	150924598	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcatgagtgtcctgctgctcCcggtcaaacgccacacctct	7	10	8	16	2	3	1	2	1	1	0	5	1	5	1	4	1	3	2	4	1	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:150924598C>T	uc003lue.3	-	9	6103	c.6090G>A	c.(6088-6090)CGG>CGA	p.R2030R	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2030	Extracellular (Potential).|Cadherin 17.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTGCTGCTCCCGGTCAAACG	0.512													96	29					0	0	0	0	T	150924598	T	T	150924598	2	4	5	1	0	0	0	0	0	0	0	1	5722	610	22	4		4	FAT2	5	150924598	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	10200915	150924598	29990662	149	1285											
CCNJL	79616	broad.mit.edu	37	chr5	159680601	159680601	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagagcaggctccctgaacgGtgggcctgcaaggagtcccg	8	5	16	12	2	0	2	0	1	0	1	2	4	2	3	3	4	3	3	3	4	2	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:159680601G>A	uc003lyb.1	-	7	1344	c.1092C>T	c.(1090-1092)CAC>CAT	p.H364H	CCNJL_uc011dee.1_Silent_p.H316H|CCNJL_uc003lyc.1_RNA	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	364						nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCCTGAACGGTGGGCCTGCA	0.662													51	18					0	0	0	0	A	159680601	A	A	159680601	2	1	5	1	0	0	0	0	0	0	0	1	2944	1252	44	4		4	CCNJL	5	159680601	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	8756003	159680601	21234659	150	1286											
ATP10B	23120	broad.mit.edu	37	chr5	160115002	160115002	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctggagagagcagcggtgtgGtttccgatggacaatggggg	8	8	19	6	2	0	1	0	0	0	1	1	5	1	3	1	6	2	2	1	6	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:160115002G>A	uc003lym.1	-	5	927	c.80C>T	c.(79-81)ACC>ATC	p.T27I	ATP10B_uc003lyp.2_Missense_Mutation_p.T27I|ATP10B_uc011deg.1_Missense_Mutation_p.T71I|ATP10B_uc003lyo.2_5'Flank	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	27	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGCGGTGTGGTTTCCGATGG	0.547													63	29					0	0	0	0	A	160115002	A	A	160115002	3	1	5	1	0	0	0	0	1	0	0	0	1119	1261	44	4	4393	4	ATP10B	5	160115002	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	434401	160115002	20800258	151	1287											
RNF44	22838	broad.mit.edu	37	chr5	175956289	175956289	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagacctgggcagtgttacCttcaaccacttgtcaacaca	11	9	8	13	0	2	1	2	0	0	1	2	1	2	1	3	1	3	3	3	1	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr5:175956289C>A	uc003mek.1	-	10	1761	c.1236G>T	c.(1234-1236)AAG>AAT	p.K412N	RNF44_uc011dfo.1_Missense_Mutation_p.K320N|RNF44_uc003mel.1_Missense_Mutation_p.K101N	NM_014901	NP_055716	Q7L0R7	RNF44_HUMAN	ring finger protein 44	412	RING-type; atypical.						zinc ion binding				0	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCAGTGTTACCTTCAACCACT	0.582													43	17					1.32136e-16	1.51355e-16	1	0	A	175956289	A	A	175956289	3	1	5	1	0	0	0	0	1	0	0	0	13561	695	24	4	70	4	RNF44	5	175956289	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	15841287	175956289	4958971	152	1288											
EXOC2	55770	broad.mit.edu	37	chr6	617752	617752	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgaagaatgtactgagaccgCctttcacataggccaggctg	11	8	11	11	2	1	2	1	1	0	2	1	4	1	2	3	2	1	2	3	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:617752C>G	uc003mtd.2	-	6	754	c.620G>C	c.(619-621)GGC>GCC	p.G207A	EXOC2_uc003mte.2_Missense_Mutation_p.G207A|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	207					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		ACTGAGACCGCCTTTCACATA	0.517													65	63					0	0	0	0	G	617752	G	G	617752	3	3	5	1	0	0	0	0	1	0	0	0	5326	739	26	4	2246	4	EXOC2	6	617752	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08		617752	170497315	153	1289											
SYCP2L	221711	broad.mit.edu	37	chr6	10899058	10899058	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttctttctttttgttagaTtatttccaggagtagtagtg	7	22	8	4	0	2	1	0	0	2	1	3	2	3	2	1	1	0	3	1	1	4	10			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:10899058T>C	uc003mzo.2	+	6	739	c.443T>C	c.(442-444)ATT>ACT	p.I148T	SYCP2L_uc011din.1_5'UTR|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	148						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TTTTGTTAGATTATTTCCAGG	0.289													88	31					0	0	0	0	C	10899058	C	C	10899058	3	2	5	1	0	0	0	0	1	0	0	0	15499	1507	52	5	465	5	SYCP2L	6	10899058	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	10281306	10899058	160216009	154	1290											
LRRC16A	55604	broad.mit.edu	37	chr6	25420376	25420376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgagccttccttgtaacagCgcgaatccccaccaaggtaa	11	7	8	15	3	0	0	0	0	0	0	2	2	2	0	6	1	3	2	6	1	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:25420376C>T	uc011djw.1	+	3	549	c.173C>T	c.(172-174)GCG>GTG	p.A58V	LRRC16A_uc010jpx.2_Missense_Mutation_p.A58V|LRRC16A_uc010jpy.2_Missense_Mutation_p.A58V	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	58					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						CTTGTAACAGCGCGAATCCCC	0.483													8	234					0	0	0	0	T	25420376	T	T	25420376	3	4	5	1	0	0	0	0	1	0	0	0	9021	768	27	1	183	1	LRRC16A	6	25420376	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	14521318	25420376	145694691	155	1291											
HIST1H1T	3010	broad.mit.edu	37	chr6	26107832	26107832	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcctttctcccgctcctaaCagttttaggagttgtcgctc	6	14	8	13	2	1	0	0	0	1	0	5	1	2	1	3	1	2	4	3	1	2	5	rs148167379		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:26107832C>G	uc003ngj.2	-	1	533	c.490G>C	c.(490-492)GTT>CTT	p.V164L		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	164					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						CCGCTCCTAACAGTTTTAGGA	0.483													155	229					0	0	0	0	G	26107832	G	G	26107832	3	3	5	1	0	0	0	0	1	0	0	0	7166	478	17	4	137	4	HIST1H1T	6	26107832	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	687456	26107832	145007235	156	1292											
PRSS16	10279	broad.mit.edu	37	chr6	27215492	27215492	+	5'Flank	DEL	G	-	-																															gataagataaaggtcctcctGggggagaacagagtcccgaa																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:27215492delG	uc003nja.2	+						PRSS16_uc011dkt.1_5'Flank|PRSS16_uc003njb.2_5'Flank|PRSS16_uc010jqq.1_5'Flank|PRSS16_uc010jqr.1_5'Flank|PRSS16_uc003njc.1_5'Flank	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor						protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						AGGTCCTCCTGGGGGAGAACA	0.567													---	---	---								-	27215492	-	-	27215492	6	5	5	0	1	1	0	1	0	0	0	0	12678	1363	47	0		0	PRSS16	6	27215492	5'Flank	DEL	G	TCGA-BA-4078-01A-01D-1434-08	1107660	27215492	143899575	157	1293											
TRIM27	5987	broad.mit.edu	37	chr6	28876602	28876602	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccttggattttctccataTctgactgcattttttctaag	8	19	5	9	0	3	1	0	1	3	0	4	2	3	2	2	1	2	1	2	1	3	9			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:28876602T>A	uc003nlr.2	-	6	1261	c.902A>T	c.(901-903)GAT>GTT	p.D301V	TRIM27_uc003nls.2_Missense_Mutation_p.D301V|TRIM27_uc003nlt.1_Missense_Mutation_p.D301V	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	301	Potential.|B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						TTTCTCCATATCTGACTGCAT	0.368			T	RET	papillary thyroid								24	10					0	0	0	0	A	28876602	A	A	28876602	3	1	5	1	0	0	0	0	1	0	0	0	16568	1435	50	5	651	5	TRIM27	6	28876602	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	1661110	28876602	142238465	158	1294											
ZBTB22	9278	broad.mit.edu	37	chr6	33283758	33283758	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatctgggtcttggggaacCaggggtgttggcgctgggca	6	9	19	7	1	2	1	0	0	2	1	2	2	2	2	1	7	1	3	1	7	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:33283758C>A	uc003oeb.2	-	2	1088	c.936G>T	c.(934-936)CTG>CTT	p.L312L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.L312L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTTGGGGAACCAGGGGTGTTG	0.567													48	104					7.77372e-23	9.5281e-23	1	0	A	33283758	A	A	33283758	2	1	5	1	0	0	0	0	0	0	0	1	17597	581	21	4		4	ZBTB22	6	33283758	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4407156	33283758	137831309	159	1295											
ITPR3	3710	broad.mit.edu	37	chr6	33657174	33657175	+	Frame_Shift_Ins	INS	-	G	G																															gggcccacactcaacatcctINSgggtgccctcaatgtgagtg																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:33657174_33657175insG	uc011drk.1	+	50	7073_7074	c.6854_6855insG	c.(6853-6855)CTGfs	p.L2285fs	ITPR3_uc003oey.2_Frame_Shift_Ins_p.L372fs	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2285	Helical; (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CTCAACATCCTGGGTGCCCTCA	0.614													---	---	---								G	33657175	G	G	33657174	7	5	5	1	0	1	1	0	0	0	0	0	7961	1580	55	0	7052	0	ITPR3	6	33657174	Frame_Shift_Ins	INS	-	TCGA-BA-4078-01A-01D-1434-08	373416	33657174	137457893	160	1296											
DNAH8	1769	broad.mit.edu	37	chr6	38840416	38840416	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgaaggcgcaaacagaatgCggaaggcctcatagagaaat	17	5	12	7	2	1	3	1	1	0	2	1	5	1	4	1	3	2	1	1	3	6	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:38840416C>T	uc003ooe.1	+	48	7044	c.6444C>T	c.(6442-6444)TGC>TGT	p.C2148C		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAACAGAATGCGGAAGGCCTC	0.483													66	106					0	0	0	0	T	38840416	T	T	38840416	2	4	5	1	0	0	0	0	0	0	0	1	4629	776	27	1		1	DNAH8	6	38840416	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5183242	38840416	132274651	161	1297											
KCNK17	89822	broad.mit.edu	37	chr6	39272355	39272355	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggttgagcaccacgaggttGagtgggatccccacaagggc	9	6	15	11	2	0	2	0	2	0	0	1	4	1	3	3	4	1	3	3	4	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:39272355G>C	uc003ooo.2	-	3	569	c.429C>G	c.(427-429)CTC>CTG	p.L143L	KCNK17_uc003oop.2_Silent_p.L143L	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	143	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						CCACGAGGTTGAGTGGGATCC	0.637													91	172					0	0	0	0	C	39272355	C	C	39272355	2	2	5	1	0	0	0	0	0	0	0	1	8103	1277	45	2		2	KCNK17	6	39272355	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	431939	39272355	131842712	162	1298											
UBR2	23304	broad.mit.edu	37	chr6	42637959	42637959	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgtgttggggtagctgcgcGtacaccatccaaagcatagg	10	9	13	9	2	0	0	0	0	0	0	1	0	1	0	2	3	4	5	2	3	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:42637959G>T	uc011dur.1	+	35	4011	c.4011G>T	c.(4009-4011)GCG>GCT	p.A1337A	UBR2_uc011dus.1_Silent_p.A982A|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1337					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GTAGCTGCGCGTACACCATCC	0.408													69	91					2.26907e-38	3.16264e-38	1	0	T	42637959	T	T	42637959	2	4	5	1	0	0	0	0	0	0	0	1	16970	1132	40	3		3	UBR2	6	42637959	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3365604	42637959	128477108	163	1299											
PKHD1	5314	broad.mit.edu	37	chr6	51890864	51890864	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggggctggcagggtttcacaCcagatgctcgcctccgttaa	7	9	13	12	2	1	1	1	0	0	1	3	1	2	1	3	4	1	5	3	4	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:51890864C>T	uc003pah.1	-	32	4020	c.3744G>A	c.(3742-3744)TGG>TGA	p.W1248*	PKHD1_uc003pai.2_Nonsense_Mutation_p.W1248*	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1248	Extracellular (Potential).|IPT/TIG 7.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGGTTTCACACCAGATGCTCG	0.597													44	57					0	0	0	0	T	51890864	T	T	51890864	4	4	5	1	0	0	0	0	0	1	0	0	12026	508	18	4	8663	4	PKHD1	6	51890864	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	9252905	51890864	119224203	164	1300											
GSTA3	2940	broad.mit.edu	37	chr6	52762651	52762651	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggaagttggagataaggCtggagtcaagctcttccaca	12	8	14	7	0	2	1	1	0	1	1	3	5	3	3	1	4	1	3	1	4	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:52762651C>T	uc003pbb.2	-	6	597	c.518G>A	c.(517-519)AGC>AAC	p.S173N	GSTA3_uc010jzq.2_Missense_Mutation_p.S117N	NM_000847	NP_000838	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	173	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity				0	Lung NSC(77;0.0912)				Glutathione(DB00143)	GGAGATAAGGCTGGAGTCAAG	0.522													77	128					0	0	0	0	T	52762651	T	T	52762651	3	4	5	1	0	0	0	0	1	0	0	0	6871	797	28	4	158	4	GSTA3	6	52762651	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	871787	52762651	118352416	165	1301											
GFRAL	389400	broad.mit.edu	37	chr6	55216213	55216213	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acggttcttctatcaaaataTaccttttaacattgcccaga	13	14	4	10	1	3	1	1	0	2	1	3	1	3	1	2	1	3	1	2	1	6	8			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:55216213T>A	uc003pcm.1	+	5	619	c.533T>A	c.(532-534)ATA>AAA	p.I178K		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	178	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TATCAAAATATACCTTTTAAC	0.428													164	222					0	0	0	0	A	55216213	A	A	55216213	3	1	5	1	0	0	0	0	1	0	0	0	6388	1406	49	5	551	5	GFRAL	6	55216213	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	2453562	55216213	115898854	166	1302											
HMGCLL1	54511	broad.mit.edu	37	chr6	55441888	55441888	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atatttacccagtggatacaAgccaccgtgcctgccaagga	12	8	9	12	1	0	0	0	0	0	0	0	2	0	2	5	2	5	0	5	2	5	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:55441888A>C	uc003pcn.2	-	2	345	c.186T>G	c.(184-186)GCT>GCG	p.A62A	HMGCLL1_uc003pco.2_Intron|HMGCLL1_uc010jzx.2_Intron|HMGCLL1_uc011dxc.1_Intron|HMGCLL1_uc011dxd.1_Intron|HMGCLL1_uc011dxe.1_Intron|HMGCLL1_uc003pcp.2_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	62							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			agtggatacaagccaccgtgc	0													14	21					0	0	0	0	C	55441888	C	C	55441888	2	2	5	1	0	0	0	0	0	0	0	1	7269	59	3	5		5	HMGCLL1	6	55441888	Silent	SNP	A	TCGA-BA-4078-01A-01D-1434-08	225675	55441888	115673179	167	1303											
PHIP	55023	broad.mit.edu	37	chr6	79679576	79679576	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attccatcgcctgtattttgCatcatcaaattgttgtctca	9	17	5	10	1	3	0	3	0	1	0	6	0	4	0	2	0	1	3	2	0	2	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:79679576C>A	uc003pir.2	-	27	3407	c.3181G>T	c.(3181-3183)GCA>TCA	p.A1061S	PHIP_uc003piq.2_Missense_Mutation_p.A85S|PHIP_uc011dyp.1_Missense_Mutation_p.A1060S	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1061	Mediates interaction with IRS1 (By similarity).				insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		CTGTATTTTGCATCATCAAAT	0.308													21	37					3.10358e-05	3.21588e-05	1	0	A	79679576	A	A	79679576	3	1	5	1	0	0	0	0	1	0	0	0	11897	710	25	4	2340	4	PHIP	6	79679576	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	24237688	79679576	91435491	168	1304											
SNX14	57231	broad.mit.edu	37	chr6	86235871	86235871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacatctggtagtatcttatCaagaaattgtgtttccccac	11	15	6	9	0	3	1	1	0	2	1	4	1	4	1	2	1	1	3	2	1	6	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:86235871C>T	uc003pkr.2	-	21	2273	c.2080G>A	c.(2080-2082)GAT>AAT	p.D694N	SNX14_uc003pkp.2_Missense_Mutation_p.D557N|SNX14_uc003pkq.2_Missense_Mutation_p.D300N|SNX14_uc011dzg.1_Missense_Mutation_p.D642N|SNX14_uc003pks.2_Missense_Mutation_p.D641N|SNX14_uc003pkt.2_Missense_Mutation_p.D685N	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	694					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		AGTATCTTATCAAGAAATTGT	0.323													12	24					0	0	0	0	T	86235871	T	T	86235871	3	4	5	1	0	0	0	0	1	0	0	0	14949	826	29	2	796	2	SNX14	6	86235871	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	6556295	86235871	84879196	169	1305											
ZNF292	23036	broad.mit.edu	37	chr6	87928449	87928449	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccattggataaggataaaGgtaaattttcgagagacaga	18	9	10	4	1	0	2	0	0	0	2	1	6	0	4	1	3	1	1	1	3	6	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:87928449G>C	uc003plm.3	+	4	579	c.538G>C	c.(538-540)GTG>CTG	p.V180L	ZNF292_uc003pll.1_Missense_Mutation_p.G180R	NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TAAGGATAAAGGTAAATTTTC	0.328													6	8					0	0	0	0	C	87928449	C	C	87928449	3	2	5	1	0	0	0	0	1	0	0	0	17893	1014	35	4	552	4	ZNF292	6	87928449	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1692578	87928449	83186618	170	1306											
GJA10	84694	broad.mit.edu	37	chr6	90604608	90604608	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aactgaggaggttagaggagCagaagaggatccataaagtc	16	6	14	5	0	0	4	0	1	0	3	2	7	1	7	1	4	2	2	1	4	5	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:90604608C>T	uc011eaa.1	+	1	421	c.421C>T	c.(421-423)CAG>TAG	p.Q141*		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	141	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		GTTAGAGGAGCAGAAGAGGAT	0.463													49	72					0	0	0	0	T	90604608	T	T	90604608	4	4	5	1	0	0	0	0	0	1	0	0	6438	711	25	4	423	4	GJA10	6	90604608	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2676159	90604608	80510459	171	1307											
LIN28B	389421	broad.mit.edu	37	chr6	105406115	105406115	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attcatctccatgataaaccGagagggaagccccttggata	13	9	9	10	1	2	2	1	1	1	1	3	5	2	4	4	2	2	0	4	2	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:105406115G>A	uc003pqv.1	+	2	355	c.152G>A	c.(151-153)CGA>CAA	p.R51Q	LIN28B_uc010kda.1_Missense_Mutation_p.R11Q	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	51	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				ATGATAAACCGAGAGGGAAGC	0.498													99	154					0	0	0	0	A	105406115	A	A	105406115	3	1	5	1	0	0	0	0	1	0	0	0	8848	1058	37	1	158	1	LIN28B	6	105406115	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	14801507	105406115	65708952	172	1308											
DDO	8528	broad.mit.edu	37	chr6	110714170	110714170	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcacgcctggcctgtagggCctcaagcccaccttctccct	5	8	9	19	2	2	0	1	0	1	0	3	0	2	0	6	2	1	2	6	2	2	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:110714170C>T	uc003puc.2	-	5	922	c.918G>A	c.(916-918)AGG>AGA	p.R306R	C6orf186_uc003pub.2_Intron|DDO_uc003pud.2_Silent_p.R247R	NM_003649	NP_003640	Q99489	OXDD_HUMAN	D-aspartate oxidase isoform a	278		Substrate (By similarity).		R -> S (in Ref. 2; BAF85718).	aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			ovary(2)|breast(1)	3		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		GCCTGTAGGGCCTCAAGCCCA	0.607													138	221					0	0	0	0	T	110714170	T	T	110714170	2	4	5	1	0	0	0	0	0	0	0	1	4351	738	26	4		4	DDO	6	110714170	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5308055	110714170	60400897	173	1309											
LAMA4	3910	broad.mit.edu	37	chr6	112443312	112443312	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctattgctctagggctgttGgaaaggtggcaatgagagtt	9	13	14	5	0	2	1	0	1	2	1	2	3	2	2	0	4	1	5	0	4	4	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:112443312G>A	uc003pvu.2	-	32	4689	c.4380C>T	c.(4378-4380)TCC>TCT	p.S1460S	LAMA4_uc003pvv.2_Silent_p.S1453S|LAMA4_uc003pvt.2_Silent_p.S1453S	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1460					cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TAGGGCTGTTGGAAAGGTGGC	0.453													80	115					0	0	0	0	A	112443312	A	A	112443312	2	1	5	1	0	0	0	0	0	0	0	1	8648	1335	47	4		4	LAMA4	6	112443312	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1729142	112443312	58671755	174	1310											
FAM184A	79632	broad.mit.edu	37	chr6	119338048	119338048	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctcttccaatctacttTgcaggtttttaagttccctt	6	18	4	13	0	2	0	0	0	2	0	5	0	5	0	4	1	2	3	4	1	3	8			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:119338048T>C	uc003pyj.2	-	5	1742	c.1394A>G	c.(1393-1395)CAA>CGA	p.Q465R	FAM184A_uc003pyk.3_Missense_Mutation_p.Q345R|FAM184A_uc003pyl.3_Missense_Mutation_p.Q345R	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	465	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						CAATCTACTTTGCAGGTTTTT	0.373													54	81					0	0	0	0	C	119338048	C	C	119338048	3	2	5	1	0	0	0	0	1	0	0	0	5539	1812	63	5	2084	5	FAM184A	6	119338048	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	6894736	119338048	51777019	175	1311											
THEMIS	387357	broad.mit.edu	37	chr6	128040968	128040968	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggttatgtctacgtgatgacGctgaaatgacacaggtcaca	12	10	11	8	2	2	4	1	4	1	0	2	4	2	4	0	2	1	2	0	2	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:128040968G>T	uc003qbi.2	-	6	2078	c.1759C>A	c.(1759-1761)CGT>AGT	p.R587S	THEMIS_uc010kfa.2_Missense_Mutation_p.R490S|THEMIS_uc011ebt.1_Missense_Mutation_p.R626S|THEMIS_uc010kfb.2_Missense_Mutation_p.R552S	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	587					negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						ACGTGATGACGCTGAAATGAC	0.368													74	81					2.51111e-31	3.30271e-31	1	0	T	128040968	T	T	128040968	3	4	5	1	0	0	0	0	1	0	0	0	15926	1101	38	3	174	3	THEMIS	6	128040968	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	8702920	128040968	43074099	176	1312											
LAMA2	3908	broad.mit.edu	37	chr6	129775417	129775417	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgactcatattggtacCgtatcgtagcatcaaggtaa	12	13	9	7	2	2	2	2	2	0	0	3	2	2	2	1	2	2	5	1	2	6	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:129775417C>A	uc003qbn.2	+	46	6796	c.6691C>A	c.(6691-6693)CGT>AGT	p.R2231S	LAMA2_uc003qbo.2_Missense_Mutation_p.R2231S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2231	Laminin G-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATATTGGTACCGTATCGTAGC	0.363													47	46					2.81731e-22	3.41985e-22	1	0	A	129775417	A	A	129775417	3	1	5	1	0	0	0	0	1	0	0	0	8646	652	23	3	6877	3	LAMA2	6	129775417	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1734449	129775417	41339650	177	1313											
SAMD3	154075	broad.mit.edu	37	chr6	130465774	130465774	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctaggaagttgaaagtttggGacagtcttcttggacactca	11	12	11	7	0	3	1	1	1	2	0	3	4	3	4	0	3	0	2	0	3	3	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:130465774G>T	uc003qbv.2	-	13	1780	c.1454C>A	c.(1453-1455)TCC>TAC	p.S485Y	SAMD3_uc003qbx.2_Missense_Mutation_p.S485Y|SAMD3_uc003qbw.2_Missense_Mutation_p.S485Y	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	485										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		GAAAGTTTGGGACAGTCTTCT	0.438													63	100					7.55815e-43	1.07974e-42	1	0	T	130465774	T	T	130465774	3	4	5	1	0	0	0	0	1	0	0	0	13885	1174	41	2	112	2	SAMD3	6	130465774	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	690357	130465774	40649293	178	1314											
TMEM200A	114801	broad.mit.edu	37	chr6	130762115	130762115	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggagcaaaggcaaatgaacgGcatgtacactggtttgatgg	13	8	14	6	1	0	2	0	2	0	0	0	3	0	3	0	5	3	5	0	5	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:130762115G>T	uc003qca.2	+	3	1419	c.548G>T	c.(547-549)GGC>GTC	p.G183V	TMEM200A_uc010kfh.2_Missense_Mutation_p.G183V|TMEM200A_uc010kfi.2_Missense_Mutation_p.G183V|TMEM200A_uc003qcb.2_Missense_Mutation_p.G183V	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	183	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CAAATGAACGGCATGTACACT	0.443													49	62					4.10826e-27	5.2287e-27	1	0	T	130762115	T	T	130762115	3	4	5	1	0	0	0	0	1	0	0	0	16189	1203	42	4	550	4	TMEM200A	6	130762115	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	296341	130762115	40352952	179	1315											
TXLNB	167838	broad.mit.edu	37	chr6	139576740	139576740	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcttgctccttcagcactttCgcctgaagtttccactctgc	5	15	6	15	1	3	1	1	1	2	0	6	1	5	1	3	0	3	3	3	0	1	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:139576740C>T	uc011eds.1	-	7	1203	c.1038G>A	c.(1036-1038)GCG>GCA	p.A346A		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	346	Potential.					cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TCAGCACTTTCGCCTGAAGTT	0.512													61	80					0	0	0	0	T	139576740	T	T	139576740	2	4	5	1	0	0	0	0	0	0	0	1	16856	871	31	1		1	TXLNB	6	139576740	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	8814625	139576740	31538327	180	1316											
UTRN	7402	broad.mit.edu	37	chr6	144843114	144843114	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttttttttgctgtttttgtAggcaatccctattcaacaga	8	20	6	7	0	1	1	1	0	0	1	2	1	2	1	1	1	2	4	1	1	4	9			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:144843114A>G	uc003qkt.2	+	39	5634	c.5542_splice	c.e39-2	p.A1848_splice		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin						muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CTGTTTTTGTAGGCAATCCCT	0.289													3	150					0	0	0	0	G	144843114	G	G	144843114	5	3	5	1	0	0	0	0	0	0	1	0	17171	434	15	5	5694	5	UTRN	6	144843114	Splice_Site	SNP	A	TCGA-BA-4078-01A-01D-1434-08	5266374	144843114	26271953	181	1317											
MYCT1	80177	broad.mit.edu	37	chr6	153043144	153043144	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttccctggaacaagcaaattCctttccaagaaaatcaagtt	15	11	5	10	0	1	1	1	0	0	1	4	2	4	2	3	1	2	2	3	1	7	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:153043144C>G	uc003qpd.3	+	2	472	c.464C>G	c.(463-465)TCC>TGC	p.S155C	MYCT1_uc010kjc.1_Missense_Mutation_p.S107C|MYCT1_uc003qpc.3_Missense_Mutation_p.S155C	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	155						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		CAAGCAAATTCCTTTCCAAGA	0.498													76	121					0	0	0	0	G	153043144	G	G	153043144	3	3	5	1	0	0	0	0	1	0	0	0	10075	855	30	2	470	2	MYCT1	6	153043144	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	8200030	153043144	18071923	182	1318											
TMEM181	57583	broad.mit.edu	37	chr6	159052421	159052421	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggatgatgatgtgatttatgGgtaagtccctgtccgttaga	9	14	13	5	1	0	4	0	3	0	1	2	5	2	5	2	2	0	2	2	2	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:159052421G>T	uc003qrm.3	+	16	1771	c.1760G>T	c.(1759-1761)GGG>GTG	p.G587V		NM_020823	NP_065874	Q9P2C4	TM181_HUMAN	G protein-coupled receptor 178	587					pathogenesis	integral to membrane	toxin binding			ovary(2)|central_nervous_system(1)	3		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		GTGATTTATGGGTAAGTCCCT	0.468													81	127					1.32764e-51	1.99146e-51	1	0	T	159052421	T	T	159052421	3	4	5	1	0	0	0	0	1	0	0	0	16166	1246	43	4	1822	4	TMEM181	6	159052421	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	6009277	159052421	12062646	183	1319											
PLG	5340	broad.mit.edu	37	chr6	161173182	161173182	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccttctcaaggaagcccagCtccctgtgattgagaataaa	12	9	9	11	0	1	2	1	2	1	1	3	4	2	3	3	1	2	1	3	1	5	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:161173182C>A	uc003qtm.3	+	18	2224	c.2161C>A	c.(2161-2163)CTC>ATC	p.L721I		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	721	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGAAGCCCAGCTCCCTGTGAT	0.468													49	65					5.73435e-26	7.22528e-26	1	0	A	161173182	A	A	161173182	3	1	5	1	0	0	0	0	1	0	0	0	12141	797	28	4	2235	4	PLG	6	161173182	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2120761	161173182	9941885	184	1320											
PDE10A	10846	broad.mit.edu	37	chr6	165832247	165832247	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcacaacgatcggcattcaCcaggttttttgcatatatct	10	13	7	11	3	2	0	1	0	1	0	3	1	2	0	1	2	2	4	1	2	3	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr6:165832247C>A	uc003qun.2	-	12	1085	c.844G>T	c.(844-846)GTG>TTG	p.V282L	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.V212L|PDE10A_uc003quo.2_Missense_Mutation_p.V292L	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	282	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TCGGCATTCACCAGGTTTTTT	0.353													25	45					4.59853e-10	4.99495e-10	1	0	A	165832247	A	A	165832247	3	1	5	1	0	0	0	0	1	0	0	0	11684	507	18	4	1543	4	PDE10A	6	165832247	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4659065	165832247	5282820	185	1321											
RAC1	5879	broad.mit.edu	37	chr7	6441558	6441558	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcatcctagtgggaactaaActtgatcttagggatgataa	14	12	9	6	0	2	2	1	2	1	0	3	4	3	4	1	2	2	0	1	2	6	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:6441558A>C	uc003spx.2	+	5	589	c.348A>C	c.(346-348)AAA>AAC	p.K116N	RAC1_uc003spw.2_Missense_Mutation_p.K135N	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	116	GTP (By similarity).				actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	TGGGAACTAAACTTGATCTTA	0.493													79	79					0	0	0	0	C	6441558	C	C	6441558	3	2	5	1	0	0	0	0	1	0	0	0	13039	40	2	5	427	5	RAC1	7	6441558	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08		6441558	152697105	186	1322											
C7orf26	79034	broad.mit.edu	37	chr7	6639935	6639936	+	Missense_Mutation	DNP	GG	TT	TT																															gagctctcgctggaccggctGgcgcaggctctgcaggtggc																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:6639935_6639936GG>TT	uc003sqo.1	+	4	1056_1057	c.1056_1057GG>TT	c.(1054-1059)CTGGCG>CTTTCG	p.A353S	C7orf26_uc003sqp.1_Missense_Mutation_p.A256S|C7orf26_uc003sqq.1_Missense_Mutation_p.A154S	NM_024067	NP_076972	Q96N11	CG026_HUMAN	hypothetical protein LOC79034	353										ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		TGGACCGGCTGGCGCAGGCTCT	0.668													19	34					0	0	0	0	TT	6639936	TT	TT	6639935	3	4	5	1	0	0	0	0	1	0	0	0	2392	1335	47	4	1070	4	C7orf26	7	6639935	Missense_Mutation	DNP	GG	TCGA-BA-4078-01A-01D-1434-08	198377	6639935	152498728	187	1323											
DNAH11	8701	broad.mit.edu	37	chr7	21730396	21730396	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggtagatttgtatttcttGgggaagctatcacactgaag	11	14	11	5	0	2	2	1	1	1	1	2	3	2	3	0	3	1	3	0	3	5	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:21730396G>T	uc003svc.2	+	36	5990	c.5959G>T	c.(5959-5961)GGG>TGG	p.G1987W		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1987	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TGTATTTCTTGGGGAAGCTAT	0.353									Kartagener_syndrome				112	166					8.58103e-55	1.29641e-54	1	0	T	21730396	T	T	21730396	3	4	5	1	0	0	0	0	1	0	0	0	4621	1348	47	4	6098	4	DNAH11	7	21730396	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	15090461	21730396	137408267	188	1324											
OSBPL3	26031	broad.mit.edu	37	chr7	24856232	24856232	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acagaagaagaacttacactGgcagagtcacatgggttgtg	14	8	12	7	0	1	4	1	0	0	4	1	4	1	4	0	2	2	2	0	2	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:24856232G>A	uc003sxf.2	-	18	2429	c.2024C>T	c.(2023-2025)CCA>CTA	p.P675L	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.P639L|OSBPL3_uc003sxh.2_Missense_Mutation_p.P644L|OSBPL3_uc003sxi.2_Missense_Mutation_p.P608L	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	675					lipid transport		lipid binding|protein binding			skin(1)	1						AACTTACACTGGCAGAGTCAC	0.448													109	137					0	0	0	0	A	24856232	A	A	24856232	3	1	5	1	0	0	0	0	1	0	0	0	11333	1348	47	4	663	4	OSBPL3	7	24856232	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3125836	24856232	134282431	189	1325											
CREB5	9586	broad.mit.edu	37	chr7	28534558	28534558	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaccatctgatgattcataGgcacaaacatgaaatgactt	15	10	8	8	0	2	4	1	4	1	0	2	5	2	5	1	2	1	1	1	2	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:28534558G>A	uc003szq.2	+	3	500	c.110G>A	c.(109-111)AGG>AAG	p.R37K	CREB5_uc003szo.2_Missense_Mutation_p.R4K|CREB5_uc003szr.2_Missense_Mutation_p.R30K	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	37	C2H2-type.				positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						ATGATTCATAGGCACAAACAT	0.388													77	128					0	0	0	0	A	28534558	A	A	28534558	3	1	5	1	0	0	0	0	1	0	0	0	3875	1000	35	4	120	4	CREB5	7	28534558	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3678326	28534558	130604105	190	1326											
C7orf41	222166	broad.mit.edu	37	chr7	30174858	30174858	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggatggatttctacgccGaccccggcgtctccttctat	6	11	10	14	4	3	0	0	0	3	0	4	3	3	2	4	3	1	1	4	3	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:30174858G>T	uc011kab.1	+	1	307	c.106G>T	c.(106-108)GAC>TAC	p.D36Y	C7orf41_uc010kvr.1_RNA|C7orf41_uc003tar.1_Missense_Mutation_p.D36Y	NM_152793	NP_690006	Q8N3F0	CG041_HUMAN	hypothetical protein LOC222166	36											0						TTTCTACGCCGACCCCGGCGT	0.632													10	12					2.17888e-05	2.26144e-05	1	0	T	30174858	T	T	30174858	3	4	5	1	0	0	0	0	1	0	0	0	2402	1058	37	3	108	3	C7orf41	7	30174858	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1640300	30174858	128963805	191	1327											
DDX56	54606	broad.mit.edu	37	chr7	44608736	44608736	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacagcagctcaccctgcagCgatagcggaagccctcgatc	10	5	10	16	3	1	0	1	0	0	0	3	3	1	1	2	1	6	3	2	1	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:44608736C>A	uc003tlg.2	-	10	1929	c.1286G>T	c.(1285-1287)CGC>CTC	p.R429L	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Missense_Mutation_p.R365L|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Missense_Mutation_p.R389L|DDX56_uc010kyh.1_RNA	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	429					rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1						CACCCTGCAGCGATAGCGGAA	0.627													48	62					1.48341e-19	1.74031e-19	1	0	A	44608736	A	A	44608736	3	1	5	1	0	0	0	0	1	0	0	0	4391	768	27	3	377	3	DDX56	7	44608736	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	14433878	44608736	114529927	192	1328											
POM121L12	285877	broad.mit.edu	37	chr7	53103882	53103882	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaggagctcctggacccctGcacccgggagactctgctgg	6	6	13	16	1	1	1	0	0	1	1	2	4	2	3	5	4	3	3	5	4	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:53103882G>T	uc003tpz.2	+	1	534	c.518G>T	c.(517-519)TGC>TTC	p.C173F		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	173											0						CTGGACCCCTGCACCCGGGAG	0.582													21	28					6.21321e-17	7.12991e-17	1	0	T	53103882	T	T	53103882	3	4	5	1	0	0	0	0	1	0	0	0	12296	1319	46	4	520	4	POM121L12	7	53103882	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	8495146	53103882	106034781	193	1329											
ZNF117	51351	broad.mit.edu	37	chr7	64439659	64439659	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatgtctcatcttgtgtctaTttgaatttgaaattttatgg	9	21	7	4	0	3	2	1	2	3	0	4	2	3	2	0	1	0	0	0	1	5	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:64439659T>G	uc003ttr.2	-	4	1575	c.290A>C	c.(289-291)AAT>ACT	p.N97T		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	97						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				CTTGTGTCTATTTGAATTTGA	0.279													35	48					0	0	0	0	G	64439659	G	G	64439659	3	3	5	1	0	0	0	0	1	0	0	0	17784	1493	52	5	1165	5	ZNF117	7	64439659	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	11335777	64439659	94699004	194	1330											
CALN1	83698	broad.mit.edu	37	chr7	71571224	71571224	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggccatgcccagctcctgCttggagatgaagccgttccc	7	9	11	14	1	0	2	0	1	0	1	2	3	2	2	5	2	4	3	5	2	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:71571224C>T	uc003twa.3	-	3	701	c.174G>A	c.(172-174)AAG>AAA	p.K58K	CALN1_uc003twb.3_Silent_p.K100K|CALN1_uc003twc.3_Silent_p.K58K	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	58	EF-hand 1.|Cytoplasmic (Potential).|1 (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CCAGCTCCTGCTTGGAGATGA	0.567													28	33					0	0	0	0	T	71571224	T	T	71571224	2	4	5	1	0	0	0	0	0	0	0	1	2603	796	28	4		4	CALN1	7	71571224	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	7131565	71571224	87567439	195	1331											
LIMK1	3984	broad.mit.edu	37	chr7	73521389	73521389	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgctggctcactgggctccCcggcctcccagcgcaaggac	5	5	13	18	3	1	0	1	0	0	0	3	1	3	1	4	4	1	4	4	4	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:73521389C>T	uc003uaa.1	+	8	1096	c.931C>T	c.(931-933)CCG>TCG	p.P311S	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_Intron|LIMK1_uc003uab.2_Missense_Mutation_p.P277S|LIMK1_uc003uac.1_Missense_Mutation_p.P103S	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	311					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				ACTGGGCTCCCCGGCCTCCCA	0.701													13	16					0	0	0	0	T	73521389	T	T	73521389	3	4	5	1	0	0	0	0	1	0	0	0	8842	623	22	4	961	4	LIMK1	7	73521389	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1950165	73521389	85617274	196	1332											
CACNA2D1	781	broad.mit.edu	37	chr7	81693670	81693670	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gatgcagctccttggatgtaCctgaaacaaatattgtaata	14	12	8	7	0	0	1	0	1	0	0	1	3	1	2	2	1	4	4	2	1	6	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:81693670C>A	uc003uhr.1	-	9	985	c.729G>T	c.(727-729)TGG>TGT	p.W243C		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	243	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTTGGATGTACCTGAAACAAA	0.318													28	57					2.61193e-14	2.92797e-14	1	0	A	81693670	A	A	81693670	3	1	5	1	0	0	0	0	1	0	0	0	2560	521	18	4	2670	4	CACNA2D1	7	81693670	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	8172281	81693670	77444993	197	1333											
RUNDC3B	154661	broad.mit.edu	37	chr7	87329865	87329865	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaatgtcagttcttctagaGctaaggtaagacattggtca	14	12	9	6	0	4	2	2	0	2	2	4	2	4	2	0	2	1	3	0	2	5	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:87329865G>A	uc003ujb.2	+	4	829	c.418G>A	c.(418-420)GCT>ACT	p.A140T	ABCB1_uc003uiz.1_Intron|ABCB1_uc003uja.1_Intron|ABCB1_uc010lei.1_Intron|RUNDC3B_uc011khd.1_Missense_Mutation_p.A123T|RUNDC3B_uc011khe.1_Missense_Mutation_p.A123T|RUNDC3B_uc003ujc.2_Missense_Mutation_p.A123T|RUNDC3B_uc003ujd.2_Missense_Mutation_p.A45T	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	140	RUN.									skin(1)	1	Esophageal squamous(14;0.00164)					TTCTTCTAGAGCTAAGGTAAG	0.383													72	142					0	0	0	0	A	87329865	A	A	87329865	3	1	5	1	0	0	0	0	1	0	0	0	13810	971	34	4	432	4	RUNDC3B	7	87329865	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	5636195	87329865	71808798	198	1334											
PPP1R9A	55607	broad.mit.edu	37	chr7	94879404	94879404	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaactccaacaaaacataGaagagaataaggaaagaatg	22	4	7	8	0	0	3	0	0	0	3	1	5	1	4	2	1	3	0	2	1	10	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:94879404G>T	uc003unp.2	+	9	2449	c.2167G>T	c.(2167-2169)GAA>TAA	p.E723*	PPP1R9A_uc010lfj.2_Nonsense_Mutation_p.E745*|PPP1R9A_uc011kif.1_Nonsense_Mutation_p.E723*|PPP1R9A_uc003unq.2_Nonsense_Mutation_p.E723*|PPP1R9A_uc011kig.1_Nonsense_Mutation_p.E723*	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	723	Interacts with TGN38 (By similarity).|Potential.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			ACAAAACATAGAAGAGAATAA	0.413										HNSCC(28;0.073)			16	32					4.75885e-15	5.35371e-15	1	0	T	94879404	T	T	94879404	4	4	5	1	0	0	0	0	0	1	0	0	12438	943	33	2	2267	2	PPP1R9A	7	94879404	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	7549539	94879404	64259259	199	1335											
PON2	5445	broad.mit.edu	37	chr7	95034735	95034735	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaacttccttggagaacagaCccattgttggcataaactgt	12	11	9	9	0	0	2	0	0	0	2	1	4	1	2	2	2	3	2	2	2	4	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:95034735C>T	uc003unv.2	-	9	1093	c.972G>A	c.(970-972)GGG>GGA	p.G324G	PON2_uc003unu.2_Silent_p.G312G|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Silent_p.G237G	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	324					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			GGAGAACAGACCCATTGTTGG	0.423													57	92					0	0	0	0	T	95034735	T	T	95034735	2	4	5	1	0	0	0	0	0	0	0	1	12304	494	18	4		4	PON2	7	95034735	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	155331	95034735	64103928	200	1336											
BRI3	25798	broad.mit.edu	37	chr7	97920509	97920509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgggttcatttgctgttttgCcttgaggaagcgacgatgcc	6	14	13	8	2	1	1	1	1	0	0	1	4	1	2	2	2	4	3	2	2	1	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:97920509C>T	uc003upi.2	+	3	461	c.332C>T	c.(331-333)GCC>GTC	p.A111V	BRI3_uc011kip.1_Intron	NM_015379	NP_056194	O95415	BRI3_HUMAN	brain protein I3 isoform a	111	Helical; (Potential).					integral to membrane					0	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)					TGCTGTTTTGCCTTGAGGAAG	0.542													98	115					0	0	0	0	T	97920509	T	T	97920509	3	4	5	1	0	0	0	0	1	0	0	0	1517	739	26	4	342	4	BRI3	7	97920509	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2885774	97920509	61218154	201	1337											
MUC17	140453	broad.mit.edu	37	chr7	100677017	100677017	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcaacaactcctcttgacAcaagcacacatatcaccact	14	10	2	15	0	3	1	2	1	1	0	4	1	4	1	2	0	3	1	2	0	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:100677017A>T	uc003uxp.1	+	3	2373	c.2320A>T	c.(2320-2322)ACA>TCA	p.T774S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	774	Extracellular (Potential).|Ser-rich.|10.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCTCTTGACACAAGCACACA	0.468													226	310					0	0	0	0	T	100677017	T	T	100677017	3	4	5	1	0	0	0	0	1	0	0	0	10027	159	6	5	2330	5	MUC17	7	100677017	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	2756508	100677017	58461646	202	1338											
MUC17	140453	broad.mit.edu	37	chr7	100685698	100685698	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaccagcacacctgtgatCacttctacccaagtcagttc	11	9	6	15	0	3	1	2	1	1	0	4	2	3	1	3	0	2	2	3	0	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:100685698C>A	uc003uxp.1	+	3	11054	c.11001C>A	c.(10999-11001)ATC>ATA	p.I3667I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3667	Extracellular (Potential).|59.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACCTGTGATCACTTCTACCC	0.502													86	138					4.47867e-22	5.39496e-22	1	0	A	100685698	A	A	100685698	2	1	5	1	0	0	0	0	0	0	0	1	10027	816	29	2		2	MUC17	7	100685698	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	8681	100685698	58452965	203	1339											
CUX1	1523	broad.mit.edu	37	chr7	101837129	101837129	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctcttgcagcattctgAagtccatggagtttgcaccg	7	13	11	10	1	2	1	0	1	2	0	3	2	3	2	2	1	4	5	2	1	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:101837129A>T	uc003uyx.3	+	13	1122	c.1084A>T	c.(1084-1086)AAG>TAG	p.K362*	CUX1_uc003uys.3_Nonsense_Mutation_p.K373*|CUX1_uc003uyt.2_Nonsense_Mutation_p.K373*|CUX1_uc011kkn.1_Nonsense_Mutation_p.K334*|CUX1_uc003uyw.2_Nonsense_Mutation_p.K327*|CUX1_uc003uyv.2_Nonsense_Mutation_p.K357*|CUX1_uc003uyu.2_Nonsense_Mutation_p.K371*	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	362	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CAGCATTCTGAAGTCCATGGA	0.378													24	27					0	0	0	0	T	101837129	T	T	101837129	4	4	5	1	0	0	0	0	0	1	0	0	4081	247	9	5	1201	5	CUX1	7	101837129	Nonsense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	1151431	101837129	57301534	204	1340											
RELN	5649	broad.mit.edu	37	chr7	103234159	103234159	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agcacatatccaggtttcagGgtcaaatctcgagttactgc	11	11	9	10	1	3	0	2	0	1	0	5	1	4	0	1	2	3	3	1	2	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:103234159G>T	uc003vca.2	-	27	4042	c.3882C>A	c.(3880-3882)ACC>ACA	p.T1294T	RELN_uc010liz.2_Silent_p.T1294T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1294					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGGTTTCAGGGTCAAATCTC	0.393													83	153					1.55023e-36	2.13708e-36	1	0	T	103234159	T	T	103234159	2	4	5	1	0	0	0	0	0	0	0	1	13285	1219	43	4		4	RELN	7	103234159	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1397030	103234159	55904504	205	1341											
GPR22	2845	broad.mit.edu	37	chr7	107115363	107115363	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtagtctttggtgtaagaacTtcagtttctgtaataattgc	10	17	9	5	0	3	1	1	0	2	1	3	1	3	1	0	1	2	4	0	1	5	8			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:107115363T>A	uc003vef.2	+	3	2204	c.858T>A	c.(856-858)ACT>ACA	p.T286T	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	286	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						GTGTAAGAACTTCAGTTTCTG	0.408													51	49					0	0	0	0	A	107115363	A	A	107115363	2	1	5	1	0	0	0	0	0	0	0	1	6720	1596	56	5		5	GPR22	7	107115363	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	3881204	107115363	52023300	206	1342											
PPP1R3A	5506	broad.mit.edu	37	chr7	113519932	113519932	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatttgaagtagtttcctcTgaaggttgatgtgtacagtc	10	16	10	5	0	1	3	0	3	1	0	3	3	2	3	1	1	1	4	1	1	5	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:113519932T>C	uc010ljy.1	-	4	1246	c.1215A>G	c.(1213-1215)TCA>TCG	p.S405S		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	405					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TAGTTTCCTCTGAAGGTTGAT	0.413													186	203					0	0	0	0	C	113519932	C	C	113519932	2	2	5	1	0	0	0	0	0	0	0	1	12431	1567	55	5		5	PPP1R3A	7	113519932	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	6404569	113519932	45618731	207	1343											
C7orf58	79974	broad.mit.edu	37	chr7	120629907	120629907	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttccttctctctggtaatGcccaggaaaccagaaaggta	11	10	9	11	0	2	1	0	0	2	1	4	2	3	2	3	3	2	3	3	3	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:120629907G>A	uc003vjq.3	+	2	679	c.232G>A	c.(232-234)GCC>ACC	p.A78T	C7orf58_uc003vjr.1_Missense_Mutation_p.A78T|C7orf58_uc003vjs.3_Missense_Mutation_p.A78T	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	78						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CTCTGGTAATGCCCAGGAAAC	0.458													60	98					0	0	0	0	A	120629907	A	A	120629907	3	1	5	1	0	0	0	0	1	0	0	0	2416	1319	46	4	234	4	C7orf58	7	120629907	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	7109975	120629907	38508756	208	1344											
FLNC	2318	broad.mit.edu	37	chr7	128488080	128488080	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccagccactgacgggccctAcacggtagccgtcaagtatg	9	6	11	15	3	1	1	1	1	0	0	1	1	1	1	4	2	3	2	4	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:128488080A>G	uc003vnz.3	+	26	4747	c.4538A>G	c.(4537-4539)TAC>TGC	p.Y1513C	FLNC_uc003voa.3_Missense_Mutation_p.Y1513C	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1513	Filamin 13.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GACGGGCCCTACACGGTAGCC	0.667													8	9					0	0	0	0	G	128488080	G	G	128488080	3	3	5	1	0	0	0	0	1	0	0	0	5967	391	14	5	4640	5	FLNC	7	128488080	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	7858173	128488080	30650583	209	1345											
PLXNA4	91584	broad.mit.edu	37	chr7	131853075	131853075	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accctcacctcctgagcagcAgcttagggtggttcttgctc	6	11	10	14	0	2	1	1	1	1	0	4	1	3	1	3	2	4	5	3	2	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:131853075A>T	uc003vra.3	-	22	4503	c.4274T>A	c.(4273-4275)CTG>CAG	p.L1425Q		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1425	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CCTGAGCAGCAGCTTAGGGTG	0.612													9	13					0	0	0	0	T	131853075	T	T	131853075	3	4	5	1	0	0	0	0	1	0	0	0	12177	188	7	5	1454	5	PLXNA4	7	131853075	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	3364995	131853075	27285588	210	1346											
PLXNA4	91584	broad.mit.edu	37	chr7	131913220	131913220	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accgctcacaccgctccttcCgggtgcaactgggaaggaca	9	6	11	15	3	1	0	1	0	0	0	3	2	3	2	4	3	2	3	4	3	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:131913220C>A	uc003vra.3	-	6	1842	c.1613G>T	c.(1612-1614)CGG>CTG	p.R538L		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	538	PSI 1.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CCGCTCCTTCCGGGTGCAACT	0.607													34	48					2.87052e-16	3.27021e-16	1	0	A	131913220	A	A	131913220	3	1	5	1	0	0	0	0	1	0	0	0	12177	652	23	3	4179	3	PLXNA4	7	131913220	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	60145	131913220	27225443	211	1347											
WDR91	29062	broad.mit.edu	37	chr7	134893687	134893687	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaaccaatccttccactcagCctggttctggagttccgtgg	8	11	9	13	1	2	0	1	0	1	0	5	1	5	1	5	3	2	2	5	3	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:134893687C>T	uc003vsp.2	-	3	429	c.367G>A	c.(367-369)GCT>ACT	p.A123T	WDR91_uc010lmq.2_5'Flank|WDR91_uc010lmr.2_5'Flank	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	123										breast(2)|ovary(1)|skin(1)	4						TTCCACTCAGCCTGGTTCTGG	0.537													81	134					0	0	0	0	T	134893687	T	T	134893687	3	4	5	1	0	0	0	0	1	0	0	0	17406	739	26	4	1928	4	WDR91	7	134893687	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2980467	134893687	24244976	212	1348											
AKR1D1	6718	broad.mit.edu	37	chr7	137773407	137773407	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgacacagggtaccgacatAttgatggggcctacatctac	11	10	10	10	1	1	2	0	2	1	0	1	3	1	2	2	3	3	1	2	3	4	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:137773407A>G	uc003vtz.2	+	2	223	c.154A>G	c.(154-156)ATT>GTT	p.I52V	AKR1D1_uc011kqb.1_Missense_Mutation_p.I52V|AKR1D1_uc011kqc.1_RNA|AKR1D1_uc011kqd.1_Intron|AKR1D1_uc011kqe.1_Missense_Mutation_p.I52V|AKR1D1_uc011kqf.1_Missense_Mutation_p.I52V	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	52					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						GTACCGACATATTGATGGGGC	0.488													32	41					0	0	0	0	G	137773407	G	G	137773407	3	3	5	1	0	0	0	0	1	0	0	0	473	449	16	5	160	5	AKR1D1	7	137773407	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	2879720	137773407	21365256	213	1349											
WEE2	494551	broad.mit.edu	37	chr7	141424933	141424933	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgctgcatggcaccatatCcgcaagggtaactttccgga	9	9	12	11	2	0	0	0	0	0	0	2	1	2	1	3	4	3	5	3	4	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:141424933C>A	uc003vwn.2	+	9	1735	c.1329C>A	c.(1327-1329)ATC>ATA	p.I443I	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	443	Protein kinase.				egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					GGCACCATATCCGCAAGGGTA	0.493													49	69					8.00217e-19	9.33586e-19	1	0	A	141424933	A	A	141424933	2	1	5	1	0	0	0	0	0	0	0	1	17413	845	30	2		2	WEE2	7	141424933	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3651526	141424933	17713730	214	1350											
MGAM	8972	broad.mit.edu	37	chr7	141803074	141803074	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctccaattcaacagaatacGatgcaaagccatataatttt	16	12	4	9	1	2	1	1	0	1	1	3	2	2	1	2	0	4	1	2	0	7	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:141803074G>A	uc003vwy.2	+	47	5385	c.5331G>A	c.(5329-5331)ACG>ACA	p.T1777T		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1777	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AACAGAATACGATGCAAAGCC	0.348													13	12					0	0	0	0	A	141803074	A	A	141803074	2	1	5	1	0	0	0	0	0	0	0	1	9594	1045	37	1		1	MGAM	7	141803074	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	378141	141803074	17335589	215	1351											
OR2F2	135948	broad.mit.edu	37	chr7	143633169	143633169	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgtcttctatgccattgttAtgcctctgctgaaccctgtg	5	16	8	12	0	3	1	0	1	3	0	3	1	3	1	3	0	4	2	3	0	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:143633169A>T	uc011ktv.1	+	1	844	c.844A>T	c.(844-846)ATG>TTG	p.M282L		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					TGCCATTGTTATGCCTCTGCT	0.463													88	111					0	0	0	0	T	143633169	T	T	143633169	3	4	5	1	0	0	0	0	1	0	0	0	11051	449	16	5	846	5	OR2F2	7	143633169	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	1830095	143633169	15505494	216	1352											
OR2A25	392138	broad.mit.edu	37	chr7	143772005	143772005	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctaaagatccagtcaggagaGgggtgccagaaagccttctc	12	7	12	10	0	2	3	1	0	1	3	4	4	3	3	3	3	2	0	3	3	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:143772005G>C	uc011ktx.1	+	1	693	c.693G>C	c.(691-693)GAG>GAC	p.E231D		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					AGTCAGGAGAGGGGTGCCAGA	0.483													92	140					0	0	0	0	C	143772005	C	C	143772005	3	2	5	1	0	0	0	0	1	0	0	0	11032	991	35	4	695	4	OR2A25	7	143772005	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	138836	143772005	15366658	217	1353											
CNTNAP2	26047	broad.mit.edu	37	chr7	146829578	146829578	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacatcacacagaccaagaTgagccaaatcgatatttcct	16	8	5	12	1	1	3	1	1	0	2	3	4	2	3	3	0	2	0	3	0	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:146829578T>A	uc003weu.1	+	8	1841	c.1325T>A	c.(1324-1326)ATG>AAG	p.M442K		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	442	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAGACCAAGATGAGCCAAATC	0.408										HNSCC(39;0.1)			48	69					0	0	0	0	A	146829578	A	A	146829578	3	1	5	1	0	0	0	0	1	0	0	0	3662	1464	51	5	1355	5	CNTNAP2	7	146829578	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	3057573	146829578	12309085	218	1354											
AGAP3	116988	broad.mit.edu	37	chr7	150837179	150837179	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaccgggaccccccgaccaGacggccccagcagtgctact	8	3	11	19	3	0	1	0	0	0	1	0	3	0	2	7	2	3	3	7	2	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:150837179G>A	uc003wjg.1	+	13	1783	c.1780G>A	c.(1780-1782)GAC>AAC	p.D594N	AGAP3_uc003wje.1_Intron|AGAP3_uc003wjj.1_Missense_Mutation_p.D93N|AGAP3_uc003wjk.1_5'UTR	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	558	PH.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						CCCCCGACCAGACGGCCCCAG	0.607													11	20					0	0	0	0	A	150837179	A	A	150837179	3	1	5	1	0	0	0	0	1	0	0	0	369	942	33	2	1897	2	AGAP3	7	150837179	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	4007601	150837179	8301484	219	1355											
ASB10	136371	broad.mit.edu	37	chr7	150878289	150878289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcgtctgctccagctgaaaGcagcaagctgcacagctgca	11	6	11	13	1	1	1	0	1	1	0	2	1	2	1	1	0	9	8	1	0	2	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:150878289G>A	uc003wjm.1	-	3	1102	c.976C>T	c.(976-978)CTT>TTT	p.L326F	ASB10_uc003wjl.1_Missense_Mutation_p.L326F|ASB10_uc003wjn.1_Missense_Mutation_p.L266F	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	281	ANK 5.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCAGCTGAAAGCAGCAAGCTG	0.677													27	40					0	0	0	0	A	150878289	A	A	150878289	3	1	5	1	0	0	0	0	1	0	0	0	1016	971	34	4	574	4	ASB10	7	150878289	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	41110	150878289	8260374	220	1356											
PTPRN2	5799	broad.mit.edu	37	chr7	157985038	157985038	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcagcggggggtctgtccTgcgccgtatgggtcctggcg	2	9	17	13	4	2	0	1	0	1	0	4	0	4	0	4	5	2	1	4	5	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr7:157985038T>C	uc003wno.2	-	5	651	c.530A>G	c.(529-531)CAG>CGG	p.Q177R	PTPRN2_uc003wnp.2_Missense_Mutation_p.Q160R|PTPRN2_uc003wnq.2_Missense_Mutation_p.Q177R|PTPRN2_uc003wnr.2_Missense_Mutation_p.Q139R|PTPRN2_uc011kwa.1_Missense_Mutation_p.Q200R	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	177	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GGGTCTGTCCTGCGCCGTATG	0.677													25	35					0	0	0	0	C	157985038	C	C	157985038	3	2	5	1	0	0	0	0	1	0	0	0	12873	1580	55	5	2593	5	PTPRN2	7	157985038	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	7106749	157985038	1153625	221	1357											
BLK	640	broad.mit.edu	37	chr8	11418850	11418850	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattgagcgcatgaattccAtccaccgcgacctgcgggcg	9	7	11	14	5	0	2	0	2	0	0	2	3	2	2	4	1	2	1	4	1	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:11418850A>G	uc003wty.2	+	11	1650	c.1069A>G	c.(1069-1071)ATC>GTC	p.I357V	BLK_uc003wtz.2_Missense_Mutation_p.I286V|BLK_uc003wua.2_Missense_Mutation_p.I193V	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	357	Protein kinase.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CATGAATTCCATCCACCGCGA	0.562													25	25					0	0	0	0	G	11418850	G	G	11418850	3	3	5	1	0	0	0	0	1	0	0	0	1447	217	8	5	1107	5	BLK	8	11418850	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08		11418850	134945172	222	1358											
PDLIM2	64236	broad.mit.edu	37	chr8	22442530	22442530	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacagtcactctctccacagGgctccgtgaggacatacact	10	8	8	15	1	2	1	1	1	1	0	5	2	4	2	2	2	1	1	2	2	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:22442530G>A	uc003xby.2	+	5	716	c.316G>A	c.(316-318)GGC>AGC	p.G106S	PDLIM2_uc003xbx.1_Missense_Mutation_p.G106S|PDLIM2_uc003xbz.2_Missense_Mutation_p.G106S|PDLIM2_uc003xca.2_Missense_Mutation_p.G106S|PDLIM2_uc003xcb.2_Missense_Mutation_p.G106S|PDLIM2_uc003xcc.1_Missense_Mutation_p.G106S	NM_021630	NP_067643	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 isoform 2	106						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		CTCTCCACAGGGCTCCGTGAG	0.637													88	127					0	0	0	0	A	22442530	A	A	22442530	3	1	5	1	0	0	0	0	1	0	0	0	11734	1246	43	4	330	4	PDLIM2	8	22442530	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	11023680	22442530	123921492	223	1359											
DPYSL2	1808	broad.mit.edu	37	chr8	26501563	26501563	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgattccggagggcaccAatggcactgaggagcggatg	9	6	15	11	2	0	2	0	2	0	0	1	5	1	5	3	5	1	2	3	5	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:26501563A>T	uc003xfb.1	+	10	1416	c.1066A>T	c.(1066-1068)AAT>TAT	p.N356Y	DPYSL2_uc003xfa.2_Missense_Mutation_p.N461Y|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Missense_Mutation_p.N320Y	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	356					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		GGAGGGCACCAATGGCACTGA	0.577													28	47					0	0	0	0	T	26501563	T	T	26501563	3	4	5	1	0	0	0	0	1	0	0	0	4769	130	5	5	1104	5	DPYSL2	8	26501563	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	4059033	26501563	119862459	224	1360											
UNC5D	137970	broad.mit.edu	37	chr8	35588529	35588529	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttggctttttctgttttaGgggtgagcttactcatacca	6	18	10	7	0	2	1	1	1	1	0	2	1	2	1	1	3	3	4	1	3	3	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:35588529G>A	uc003xjr.1	+	11	2010	c.1682_splice	c.e11-1	p.G561_splice	UNC5D_uc003xjs.1_Splice_Site_p.G556_splice|UNC5D_uc003xju.1_Splice_Site_p.G137_splice	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor						apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTCTGTTTTAGGGGTGAGCTT	0.423													40	41					0	0	0	0	A	35588529	A	A	35588529	5	1	5	1	0	0	0	0	0	0	1	0	17063	1014	35	4	1723	4	UNC5D	8	35588529	Splice_Site	SNP	G	TCGA-BA-4078-01A-01D-1434-08	9086966	35588529	110775493	225	1361											
ADAM2	2515	broad.mit.edu	37	chr8	39613295	39613295	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttatccacatcttttggctGtctgcatgatcactggcaaa	9	15	7	10	0	3	1	1	1	2	0	4	1	4	1	1	2	1	3	1	2	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:39613295G>T	uc003xnj.2	-	16	1824	c.1749C>A	c.(1747-1749)GAC>GAA	p.D583E	ADAM2_uc003xnk.2_Missense_Mutation_p.D564E|ADAM2_uc011lck.1_Intron|ADAM2_uc003xnl.2_Missense_Mutation_p.D427E	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	583	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TCTTTTGGCTGTCTGCATGAT	0.348													39	61					1.90571e-15	2.14776e-15	1	0	T	39613295	T	T	39613295	3	4	5	1	0	0	0	0	1	0	0	0	241	1368	48	4	478	4	ADAM2	8	39613295	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	4024766	39613295	106750727	226	1362											
SLC20A2	6575	broad.mit.edu	37	chr8	42294989	42294989	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagagccccgagtctttgtgCacggtgtggtacacatgacc	8	10	12	11	2	1	2	0	1	1	1	1	3	1	2	3	2	3	2	3	2	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:42294989C>A	uc010lxl.2	-	8	1735	c.1041G>T	c.(1039-1041)GTG>GTT	p.V347V	SLC20A2_uc010lxm.2_Silent_p.V347V|SLC20A2_uc003xpe.2_Silent_p.V347V|SLC20A2_uc011lcu.1_Silent_p.V149V	NM_006749	NP_006740	Q08357	S20A2_HUMAN	solute carrier family 20, member 2	347	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			ovary(2)	2	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AGTCTTTGTGCACGGTGTGGT	0.592													87	120					8.55712e-49	1.26549e-48	1	0	A	42294989	A	A	42294989	2	1	5	1	0	0	0	0	0	0	0	1	14504	697	25	4		4	SLC20A2	8	42294989	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2681694	42294989	104069033	227	1363											
RP1	6101	broad.mit.edu	37	chr8	55540694	55540694	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataagaaacatagttctctaGatgattttgaaaattgttca	16	15	6	4	0	2	4	1	2	1	2	3	4	2	4	0	0	1	2	0	0	6	8			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:55540694G>T	uc003xsd.1	+	4	4400	c.4252G>T	c.(4252-4254)GAT>TAT	p.D1418Y	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1418					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TAGTTCTCTAGATGATTTTGA	0.358													50	93					1.61004e-24	2.00459e-24	1	0	T	55540694	T	T	55540694	3	4	5	1	0	0	0	0	1	0	0	0	13597	942	33	2	4262	2	RP1	8	55540694	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	13245705	55540694	90823328	228	1364											
JPH1	56704	broad.mit.edu	37	chr8	75233335	75233340	+	In_Frame_Del	DEL	TAGCCC	-	-																															gccgcttgccctgcgcccagTagccctggtaggtgttgccg																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:75233335_75233340delTAGCCC	uc003yae.2	-	1	223_228	c.183_188delGGGCTA	c.(181-189)CAGGGCTAC>CAC	p.61_63QGY>H	JPH1_uc003yaf.2_In_Frame_Del_p.61_63QGY>H|JPH1_uc003yag.1_Intron	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	61_63	Gly-rich.|MORN 3.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CTGCGCCCAGTAGCCCTGGTAGGTGT	0.684													---	---	---								-	75233340	-	-	75233335	7	5	5	1	0	1	0	1	0	0	0	0	7999	1638	57	0	1817	0	JPH1	8	75233335	In_Frame_Del	DEL	TAGCCC	TCGA-BA-4078-01A-01D-1434-08	19692641	75233335	71130687	229	1365											
ZFHX4	79776	broad.mit.edu	37	chr8	77618582	77618582	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacaccagcctcagtggctgCggaacaccctctccgtccaa	10	6	8	17	2	2	0	1	0	1	0	4	1	3	1	5	2	4	1	5	2	3	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:77618582C>A	uc003yav.2	+	2	2646	c.2259C>A	c.(2257-2259)TGC>TGA	p.C753*	ZFHX4_uc003yat.1_Nonsense_Mutation_p.C753*|ZFHX4_uc003yau.1_Nonsense_Mutation_p.C753*|ZFHX4_uc003yaw.1_Nonsense_Mutation_p.C753*	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	753						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCAGTGGCTGCGGAACACCCT	0.527										HNSCC(33;0.089)			21	19					0.000375601	0.000386017	1	0	A	77618582	A	A	77618582	4	1	5	1	0	0	0	0	0	1	0	0	17702	776	27	3	2261	3	ZFHX4	8	77618582	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2385247	77618582	68745440	230	1366											
CNBD1	168975	broad.mit.edu	37	chr8	88363947	88363948	+	Missense_Mutation	DNP	GG	TT	TT																															ggaaatataatttcttttgtGggttatattaactctggatg																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:88363947_88363948GG>TT	uc003ydy.2	+	9	1125_1126	c.1077_1078GG>TT	c.(1075-1080)GTGGGT>GTTTGT	p.G360C		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	360	cNMP.									ovary(3)	3						TTTCTTTTGTGGGTTATATTAA	0.262													5	8					0	0	0	0	TT	88363948	TT	TT	88363947	3	4	5	1	0	0	0	0	1	0	0	0	3606	1335	47	4	1111	4	CNBD1	8	88363947	Missense_Mutation	DNP	GG	TCGA-BA-4078-01A-01D-1434-08	10745365	88363947	58000075	231	1367											
RUNX1T1	862	broad.mit.edu	37	chr8	92982970	92982970	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggcgaccgtgcgctccatCttggccctctctgttgtgat	3	13	11	14	4	2	1	0	1	2	0	5	2	3	1	3	2	1	2	3	2	0	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:92982970C>A	uc003yfd.2	-	10	1539	c.1455G>T	c.(1453-1455)AAG>AAT	p.K485N	RUNX1T1_uc003yfc.1_Missense_Mutation_p.K458N|RUNX1T1_uc003yfe.1_Missense_Mutation_p.K448N|RUNX1T1_uc010mao.2_Missense_Mutation_p.K458N|RUNX1T1_uc011lgi.1_Missense_Mutation_p.K496N|RUNX1T1_uc010man.1_Missense_Mutation_p.K110N|RUNX1T1_uc003yfb.1_Missense_Mutation_p.K448N	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	485					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TGCGCTCCATCTTGGCCCTCT	0.617													43	64					3.54909e-21	4.2267e-21	1	0	A	92982970	A	A	92982970	3	1	5	1	0	0	0	0	1	0	0	0	13812	912	32	2	367	2	RUNX1T1	8	92982970	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4619023	92982970	53381052	232	1368											
VPS13B	157680	broad.mit.edu	37	chr8	100866327	100866327	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgatccagccagtaaatttGctcgtcagcatccacgcttc	9	11	8	13	2	1	1	1	1	0	0	5	1	3	1	3	0	3	4	3	0	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:100866327G>A	uc003yiv.2	+	56	10896	c.10785G>A	c.(10783-10785)TTG>TTA	p.L3595L	VPS13B_uc003yiw.2_Silent_p.L3570L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3595					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAGTAAATTTGCTCGTCAGCA	0.542													39	46					0	0	0	0	A	100866327	A	A	100866327	2	1	5	1	0	0	0	0	0	0	0	1	17258	1310	46	4		4	VPS13B	8	100866327	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	7883357	100866327	45497695	233	1369											
TM7SF4	81501	broad.mit.edu	37	chr8	105361622	105361622	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaagtatgtcatcatccCgactttctggccgactccta	9	11	9	12	2	3	0	2	0	1	0	5	4	5	1	3	2	0	1	3	2	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:105361622C>G	uc003ylx.1	+	2	891	c.842C>G	c.(841-843)CCG>CGG	p.P281R		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	281					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GTCATCATCCCGACTTTCTGG	0.478													110	127					0	0	0	0	G	105361622	G	G	105361622	3	3	5	1	0	0	0	0	1	0	0	0	16042	652	23	3	844	3	TM7SF4	8	105361622	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4495295	105361622	41002400	234	1370											
PKHD1L1	93035	broad.mit.edu	37	chr8	110425733	110425733	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatagcaagattactagaagCactgatacacagtttacata	18	10	6	7	0	0	3	0	1	0	2	0	3	0	3	0	0	5	3	0	0	9	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:110425733C>T	uc003yne.2	+	21	2423	c.2319C>T	c.(2317-2319)AGC>AGT	p.S773S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	773	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTACTAGAAGCACTGATACAC	0.289										HNSCC(38;0.096)			7	4					0	0	0	0	T	110425733	T	T	110425733	2	4	5	1	0	0	0	0	0	0	0	1	12027	709	25	4		4	PKHD1L1	8	110425733	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5064111	110425733	35938289	235	1371											
PKHD1L1	93035	broad.mit.edu	37	chr8	110474049	110474049	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggaaagtttggagaagaaaTaggaagtgaccaatttggag	17	8	14	2	0	0	3	0	1	0	2	0	7	0	6	1	4	0	1	1	4	6	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:110474049T>A	uc003yne.2	+	48	7399	c.7295T>A	c.(7294-7296)ATA>AAA	p.I2432K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2432	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGAGAAGAAATAGGAAGTGAC	0.393										HNSCC(38;0.096)			13	16					0	0	0	0	A	110474049	A	A	110474049	3	1	5	1	0	0	0	0	1	0	0	0	12027	1406	49	5	7485	5	PKHD1L1	8	110474049	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	48316	110474049	35889973	236	1372											
KCNV1	27012	broad.mit.edu	37	chr8	110984922	110984922	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacagtgggacaaggtccttGggagaagtcctgttcactct	10	10	12	9	0	2	1	1	0	1	1	4	3	4	2	2	3	1	1	2	3	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:110984922G>T	uc003ynr.3	-	2	898	c.556C>A	c.(556-558)CAA>AAA	p.Q186K	KCNV1_uc010mcw.2_Missense_Mutation_p.Q186K	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	186	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CAAGGTCCTTGGGAGAAGTCC	0.458													61	98					1.45723e-30	1.90468e-30	1	0	T	110984922	T	T	110984922	3	4	5	1	0	0	0	0	1	0	0	0	8133	1357	47	4	954	4	KCNV1	8	110984922	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	510873	110984922	35379100	237	1373											
CSMD3	114788	broad.mit.edu	37	chr8	113277643	113277643	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaatcattatcatacctcTacaagttggcattactccac	14	12	4	11	0	3	1	2	0	1	1	4	1	4	1	2	1	3	2	2	1	6	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:113277643T>C	uc003ynu.2	-	60	9844	c.9685A>G	c.(9685-9687)AGA>GGA	p.R3229G	CSMD3_uc003yns.2_Missense_Mutation_p.R2431G|CSMD3_uc003ynt.2_Missense_Mutation_p.R3189G|CSMD3_uc011lhx.1_Missense_Mutation_p.R3060G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3229	Extracellular (Potential).|Sushi 24.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATCATACCTCTACAAGTTGGC	0.294										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			81	114					0	0	0	0	C	113277643	C	C	113277643	3	2	5	1	0	0	0	0	1	0	0	0	3963	1530	53	5	1486	5	CSMD3	8	113277643	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	2292721	113277643	33086379	238	1374											
ENPP2	5168	broad.mit.edu	37	chr8	120602744	120602744	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atattttaagaatcaacttaCatttagcattgttgctaaat	15	17	4	5	0	1	1	1	0	0	1	1	1	1	1	0	0	4	3	0	0	8	9			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:120602744C>A	uc003yot.1	-	13	1293	c.1207_splice	c.e13+1	p.Y403_splice	ENPP2_uc003yor.1_Splice_Site_p.Y42_splice|ENPP2_uc003yos.1_Splice_Site_p.Y455_splice|ENPP2_uc010mdd.1_Splice_Site_p.Y403_splice	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein						cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AATCAACTTACATTTAGCATT	0.239													29	39					7.38237e-10	7.96386e-10	1	0	A	120602744	A	A	120602744	5	1	5	1	0	0	0	0	0	0	1	0	5154	492	17	4	1514	4	ENPP2	8	120602744	Splice_Site	SNP	C	TCGA-BA-4078-01A-01D-1434-08	7325101	120602744	25761278	239	1375											
COL14A1	7373	broad.mit.edu	37	chr8	121240971	121240971	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagtttttggacagaaccAgctacaaccatagtgcctac	13	9	8	11	0	0	1	0	0	0	1	0	3	0	2	3	1	6	2	3	1	5	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:121240971A>T	uc003yox.2	+	18	2425	c.2160A>T	c.(2158-2160)CCA>CCT	p.P720P	COL14A1_uc003yoy.2_Silent_p.P398P	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	720					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGACAGAACCAGCTACAACCA	0.284													62	91					0	0	0	0	T	121240971	T	T	121240971	2	4	5	1	0	0	0	0	0	0	0	1	3686	175	7	5		5	COL14A1	8	121240971	Silent	SNP	A	TCGA-BA-4078-01A-01D-1434-08	638227	121240971	25123051	240	1376											
EFR3A	23167	broad.mit.edu	37	chr8	132971846	132971846	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaggcatttagatcatcAcaaactgtgggatcccaatg	12	11	9	9	0	2	1	2	0	0	1	3	2	3	2	1	2	2	2	1	2	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:132971846A>G	uc003yte.2	+	8	992	c.791A>G	c.(790-792)CAC>CGC	p.H264R		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	264						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TTAGATCATCACAAACTGTGG	0.279													40	69					0	0	0	0	G	132971846	G	G	132971846	3	3	5	1	0	0	0	0	1	0	0	0	4980	159	6	5	821	5	EFR3A	8	132971846	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	11730875	132971846	13392176	241	1377											
ZFAT	57623	broad.mit.edu	37	chr8	135612791	135612791	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgtgtttctgaattacgTggcgtttaaggcagtttttg	7	18	11	5	2	1	1	0	1	1	0	1	1	1	1	0	2	2	4	0	2	4	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:135612791T>C	uc003yup.2	-	7	2538	c.2363A>G	c.(2362-2364)CAC>CGC	p.H788R	ZFAT_uc003yun.2_Missense_Mutation_p.H776R|ZFAT_uc003yuo.2_Missense_Mutation_p.H776R|ZFAT_uc010meh.2_Missense_Mutation_p.H776R|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.H776R|ZFAT_uc010mej.2_Missense_Mutation_p.H726R|ZFAT_uc003yur.2_Missense_Mutation_p.H776R|ZFATAS_uc003yus.1_RNA	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	788	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTGAATTACGTGGCGTTTAAG	0.428													90	151					0	0	0	0	C	135612791	C	C	135612791	3	2	5	1	0	0	0	0	1	0	0	0	17699	1696	59	5	1408	5	ZFAT	8	135612791	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	2640945	135612791	10751231	242	1378											
FAM135B	51059	broad.mit.edu	37	chr8	139180143	139180143	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaaaacagacaaacctgtcGcagggcagtccacgtatctg	14	6	9	12	2	1	1	0	0	1	1	3	1	2	1	2	1	2	3	2	1	4	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:139180143G>T	uc003yuy.2	-	12	1424	c.1253C>A	c.(1252-1254)GCG>GAG	p.A418E	FAM135B_uc003yux.2_Missense_Mutation_p.A319E|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	418										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAAACCTGTCGCAGGGCAGTC	0.507										HNSCC(54;0.14)			91	114					1.37074e-43	1.97161e-43	1	0	T	139180143	T	T	139180143	3	4	5	1	0	0	0	0	1	0	0	0	5477	1087	38	3	3003	3	FAM135B	8	139180143	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3567352	139180143	7183879	243	1379											
COL22A1	169044	broad.mit.edu	37	chr8	139638470	139638470	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagatgggccttgggggccaGgagggccttctttcccctaa	6	9	14	12	0	1	1	0	0	1	1	2	2	2	2	5	5	0	0	5	5	1	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:139638470G>T	uc003yvd.2	-	51	4127	c.3680C>A	c.(3679-3681)CCT>CAT	p.P1227H	COL22A1_uc011ljo.1_Missense_Mutation_p.P507H	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1227	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTGGGGGCCAGGAGGGCCTTC	0.403										HNSCC(7;0.00092)			33	78					1.04352e-10	1.13937e-10	1	0	T	139638470	T	T	139638470	3	4	5	1	0	0	0	0	1	0	0	0	3696	1000	35	4	1260	4	COL22A1	8	139638470	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	458327	139638470	6725552	244	1380											
COL22A1	169044	broad.mit.edu	37	chr8	139642958	139642958	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggtgacccttggattcctgGtggtccagcagctcctgcaa	7	10	12	12	0	0	1	0	1	0	0	3	2	3	2	4	4	3	3	4	4	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:139642958G>A	uc003yvd.2	-	50	4090	c.3643C>T	c.(3643-3645)CCA>TCA	p.P1215S	COL22A1_uc011ljo.1_Missense_Mutation_p.P495S	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1215	Pro-rich.|Gly-rich.|Collagen-like 11.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TGGATTCCTGGTGGTCCAGCA	0.478										HNSCC(7;0.00092)			150	202					0	0	0	0	A	139642958	A	A	139642958	3	1	5	1	0	0	0	0	1	0	0	0	3696	1261	44	4	1301	4	COL22A1	8	139642958	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	4488	139642958	6721064	245	1381											
SCRIB	23513	broad.mit.edu	37	chr8	144877207	144877207	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cactgcacactgggcactcaCcctctgcacgctgccagcgc	7	6	9	19	2	2	0	1	0	1	0	2	0	2	0	2	1	4	4	2	1	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:144877207C>A	uc003yzp.1	-	27	3853	c.3846_splice	c.e27+1	p.R1282_splice	SCRIB_uc003yzn.1_Splice_Site|SCRIB_uc003yzo.1_Splice_Site_p.R1282_splice	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b						activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TGGGCACTCACCCTCTGCACG	0.682													21	37					1.64113e-05	1.70895e-05	1	0	A	144877207	A	A	144877207	5	1	5	1	0	0	0	0	0	0	1	0	14002	521	18	4	1164	4	SCRIB	8	144877207	Splice_Site	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5234249	144877207	1486815	246	1382											
RECQL4	9401	broad.mit.edu	37	chr8	145739431	145739431	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccacgtcactggcagtgcGgcgtgtggctgtggctgtga	4	10	17	10	3	1	1	1	1	0	0	1	1	1	1	1	4	2	3	1	4	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr8:145739431G>T	uc003zdj.2	-	12	1971	c.1939C>A	c.(1939-1941)CGC>AGC	p.R647S		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	647	Helicase ATP-binding.				DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CTGGCAGTGCGGCGTGTGGCT	0.672			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				4	4					1.23904e-05	1.29452e-05	1	0	T	145739431	T	T	145739431	3	4	5	1	0	0	0	0	1	0	0	0	13267	1116	39	3	1728	3	RECQL4	8	145739431	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	862224	145739431	624591	247	1383											
MPDZ	8777	broad.mit.edu	37	chr9	13196141	13196141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actatttcatagttaattccCataatcctttgccattttgt	10	19	3	9	0	1	0	1	0	0	0	3	0	3	0	3	0	1	1	3	0	4	9			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:13196141C>T	uc010mia.1	-	12	1692	c.1635G>A	c.(1633-1635)ATG>ATA	p.M545I	MPDZ_uc010mhy.2_Missense_Mutation_p.M545I|MPDZ_uc010mhz.2_Missense_Mutation_p.M545I|MPDZ_uc011lmn.1_Missense_Mutation_p.M545I|MPDZ_uc003zlb.3_Missense_Mutation_p.M545I	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	545					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		AGTTAATTCCCATAATCCTTT	0.383													11	3					0	0	0	0	T	13196141	T	T	13196141	3	4	5	1	0	0	0	0	1	0	0	0	9775	594	21	4	4626	4	MPDZ	9	13196141	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08		13196141	128017290	248	1384											
CDKN2A	1029	broad.mit.edu	37	chr9	21968233	21968233	+	Frame_Shift_Del	DEL	C	-	-																															gcctctctggttctttcaatCggggatgtctgcagagggca																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:21968233delC	uc003zpk.2	-	3	678	c.466delG	c.(466-468)GATfs	p.D156fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	156					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(4)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TTCTTTCAATCGGGGATGTCT	0.562		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---								-	21968233	-	-	21968233	7	5	5	1	0	1	0	1	0	0	0	0	3176	884	31	0	8	0	CDKN2A	9	21968233	Frame_Shift_Del	DEL	C	TCGA-BA-4078-01A-01D-1434-08	8772092	21968233	119245198	249	1385											
TLN1	7094	broad.mit.edu	37	chr9	35717418	35717418	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctcttggcagacaggtgagCtgattgtaggtgccaccacc	8	9	13	11	0	1	3	0	2	1	1	1	3	1	3	3	3	2	4	3	3	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:35717418C>A	uc003zxt.2	-	19	2537	c.2183G>T	c.(2182-2184)AGC>ATC	p.S728I		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	728					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GACAGGTGAGCTGATTGTAGG	0.557													68	25					9.53695e-23	1.1644e-22	1	0	A	35717418	A	A	35717418	3	1	5	1	0	0	0	0	1	0	0	0	16013	797	28	4	5598	4	TLN1	9	35717418	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	13749185	35717418	105496013	250	1386											
ZNF658	26149	broad.mit.edu	37	chr9	40774556	40774556	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcatccttacaggactttTctcctgttagaaaactctga	11	14	5	11	0	3	2	1	1	2	1	5	3	4	3	2	1	2	1	2	1	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:40774556T>C	uc004abs.2	-	5	871	c.719A>G	c.(718-720)GAA>GGA	p.E240G	ZNF658_uc010mmm.1_Missense_Mutation_p.E240G|ZNF658_uc010mmn.1_Missense_Mutation_p.E240G	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACAGGACTTTTCTCCTGTTAG	0.323													74	87					0	0	0	0	C	40774556	C	C	40774556	3	2	5	1	0	0	0	0	1	0	0	0	18136	1783	62	5	2464	5	ZNF658	9	40774556	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	5057138	40774556	100438875	251	1387											
FAM75A6	389730	broad.mit.edu	37	chr9	43630658	43630658	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggagctgggggcgtttagcGatgaggcactaagtaatttt	9	12	15	5	2	0	1	0	1	0	0	0	3	0	2	0	4	2	4	0	4	3	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:43630658G>A	uc011lrb.1	-	1	73	c.44C>T	c.(43-45)TCG>TTG	p.S15L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	15						integral to membrane					0						GGCGTTTAGCGATGAGGCACT	0.488													80	25					0	0	0	0	A	43630658	A	A	43630658	3	1	5	1	0	0	0	0	1	0	0	0	5654	1059	37	1	4003	1	FAM75A6	9	43630658	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2856102	43630658	97582773	252	1388											
RORB	6096	broad.mit.edu	37	chr9	77257706	77257706	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaacaatgggcagttagcAccagggataaccatgactga	14	8	10	9	0	1	2	1	2	0	0	1	3	1	3	2	2	3	3	2	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:77257706A>G	uc004aji.2	+	4	694	c.645A>G	c.(643-645)GCA>GCG	p.A215A	RORB_uc004ajh.2_Silent_p.A204A	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	215	Hinge (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GGCAGTTAGCACCAGGGATAA	0.408													47	70					0	0	0	0	G	77257706	G	G	77257706	2	3	5	1	0	0	0	0	0	0	0	1	13594	146	6	5		5	RORB	9	77257706	Silent	SNP	A	TCGA-BA-4078-01A-01D-1434-08	33627048	77257706	63955725	253	1389											
C9orf79	286234	broad.mit.edu	37	chr9	90502556	90502556	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaagtcaccttgggagccAgtgtgagggcaagttcggga	9	7	18	7	1	1	1	1	1	0	0	2	4	1	4	2	4	1	2	2	4	2	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:90502556A>C	uc004app.3	+	4	3189	c.3154A>C	c.(3154-3156)AGT>CGT	p.S1052R		NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	1052						integral to membrane				ovary(3)	3						CTTGGGAGCCAGTGTGAGGGC	0.592													64	121					0	0	0	0	C	90502556	C	C	90502556	3	2	5	1	0	0	0	0	1	0	0	0	2509	188	7	5	3168	5	C9orf79	9	90502556	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	13244850	90502556	50710875	254	1390											
C9orf79	286234	broad.mit.edu	37	chr9	90503213	90503213	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agagaaagatcagtcaccatCcacagggtctacaccccagg	14	5	9	13	0	3	2	2	0	1	2	4	3	4	2	4	2	1	0	4	2	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:90503213C>A	uc004app.3	+	4	3846	c.3811C>A	c.(3811-3813)CCA>ACA	p.P1271T		NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	1271						integral to membrane				ovary(3)	3						CAGTCACCATCCACAGGGTCT	0.542													31	73					1.08312e-15	1.22288e-15	1	0	A	90503213	A	A	90503213	3	1	5	1	0	0	0	0	1	0	0	0	2509	855	30	2	3825	2	C9orf79	9	90503213	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	657	90503213	50710218	255	1391											
IARS	3376	broad.mit.edu	37	chr9	95050422	95050422	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acataccacaggtaagccatGgcaatcccatccaaatcttc	14	8	5	14	0	1	0	0	0	1	0	4	0	3	0	4	2	2	2	4	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:95050422G>T	uc004art.1	-	3	519	c.262C>A	c.(262-264)CAT>AAT	p.H88N	IARS_uc004ars.1_5'UTR|IARS_uc004aru.3_Missense_Mutation_p.H88N|IARS_uc010mqr.2_Intron|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	88					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	GGTAAGCCATGGCAATCCCAT	0.333													62	71					9.4991e-31	1.24676e-30	1	0	T	95050422	T	T	95050422	3	4	5	1	0	0	0	0	1	0	0	0	7512	1348	47	4	3654	4	IARS	9	95050422	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	4547209	95050422	46163009	256	1392											
NOL8	55035	broad.mit.edu	37	chr9	95077690	95077690	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaagaagttttcttcgtaGatttttccatttgtgaaaat	12	18	7	4	1	1	4	0	2	1	2	3	4	2	4	1	0	0	2	1	0	5	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:95077690G>C	uc004arv.2	-	7	1554	c.1217C>G	c.(1216-1218)TCT>TGT	p.S406C	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.S338C	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	406					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						TTTCTTCGTAGATTTTTCCAT	0.328													17	17					0	0	0	0	C	95077690	C	C	95077690	3	2	5	1	0	0	0	0	1	0	0	0	10581	942	33	2	2330	2	NOL8	9	95077690	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	27268	95077690	46135741	257	1393											
ZNF782	158431	broad.mit.edu	37	chr9	99580614	99580614	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagcttccccacaatgattaCatttatagggtttttcccct	10	15	5	11	0	0	1	0	1	0	0	2	1	2	1	4	1	2	2	4	1	5	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:99580614C>G	uc004awp.1	-	6	1972	c.1691G>C	c.(1690-1692)TGT>TCT	p.C564S	ZNF782_uc011lup.1_Missense_Mutation_p.C432S	NM_001001662	NP_001001662	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	564	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				ACAATGATTACATTTATAGGG	0.413													156	254					0	0	0	0	G	99580614	G	G	99580614	3	3	5	1	0	0	0	0	1	0	0	0	18222	478	17	4	412	4	ZNF782	9	99580614	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4502924	99580614	41632817	258	1394											
RAD23B	5887	broad.mit.edu	37	chr9	110086243	110086243	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aattattcagcagaatccttCcttgcttccagcgttactac	10	14	5	12	1	1	1	1	0	0	1	4	1	4	1	3	0	5	3	3	0	5	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:110086243C>T	uc004bde.2	+	8	1257	c.890C>T	c.(889-891)TCC>TTC	p.S297F	RAD23B_uc011lwa.1_Missense_Mutation_p.S297F|RAD23B_uc011lwb.1_Missense_Mutation_p.S276F	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	297	STI1.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						CAGAATCCTTCCTTGCTTCCA	0.388								Direct_reversal_of_damage|NER					79	111					0	0	0	0	T	110086243	T	T	110086243	3	4	5	1	0	0	0	0	1	0	0	0	13048	855	30	2	920	2	RAD23B	9	110086243	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	10505629	110086243	31127188	259	1395											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112898848	112898848	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aaagaacagctagccggcagGcacctcctcacatcgagctc	12	5	9	15	2	1	1	1	0	0	1	4	2	2	1	3	2	4	4	3	2	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:112898848G>T	uc004bei.2	+	9	1912	c.1720G>T	c.(1720-1722)GCA>TCA	p.A574S	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.A342S|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.A342S|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.A152S|AKAP2_uc011lwi.1_Missense_Mutation_p.A200S|AKAP2_uc004bem.2_Missense_Mutation_p.A200S|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.A160S|AKAP2_uc011lwj.1_Missense_Mutation_p.A111S|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.A111S	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	111							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						TAGCCGGCAGGCACCTCCTCA	0.622													58	66					1.31171e-36	1.81223e-36	1	0	T	112898848	T	T	112898848	3	4	5	1	0	0	0	0	1	0	0	0	11464	1203	42	4	1054	4	PALM2-AKAP2	9	112898848	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2812605	112898848	28314583	260	1396											
COL27A1	85301	broad.mit.edu	37	chr9	117050772	117050772	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcaaggctgaggggccccCtgggccacctggagatcggg	6	4	18	13	2	0	2	0	1	0	1	1	3	0	2	4	7	0	2	4	7	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:117050772C>A	uc011lxl.1	+	42	4025	c.4025C>A	c.(4024-4026)CCT>CAT	p.P1342H	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1342	Collagen-like 12.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GAGGGGCCCCCTGGGCCACCT	0.662													7	13					0.00448238	0.00455468	1	0	A	117050772	A	A	117050772	3	1	5	1	0	0	0	0	1	0	0	0	3700	681	24	4	4191	4	COL27A1	9	117050772	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4151924	117050772	24162659	261	1397											
TNC	3371	broad.mit.edu	37	chr9	117793913	117793913	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggctgtgtagtgggtggatgGgctcaggtctgccaggctgt	4	11	19	7	0	2	0	1	0	1	0	2	1	2	1	1	6	1	4	1	6	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:117793913G>T	uc004bjj.3	-	23	6201	c.5839C>A	c.(5839-5841)CCA>ACA	p.P1947T	TNC_uc010mvf.2_Missense_Mutation_p.P1674T	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1947	Fibronectin type-III 15.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TGGGTGGATGGGCTCAGGTCT	0.512													78	117					2.72187e-29	3.52835e-29	1	0	T	117793913	T	T	117793913	3	4	5	1	0	0	0	0	1	0	0	0	16336	1232	43	4	790	4	TNC	9	117793913	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	743141	117793913	23419518	262	1398											
TLR4	7099	broad.mit.edu	37	chr9	120476539	120476539	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgccttcactacagagaCtttattcccggtgtggccat	7	13	8	13	1	2	1	1	0	1	1	3	2	3	1	3	2	2	0	3	2	2	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:120476539C>A	uc004bjz.2	+	3	2424	c.2133C>A	c.(2131-2133)GAC>GAA	p.D711E	TLR4_uc004bka.2_Missense_Mutation_p.D671E|TLR4_uc004bkb.2_Missense_Mutation_p.D511E	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	711	Cytoplasmic (Potential).|TIR.			D->K: Abolishes LPS-response.	activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ACTACAGAGACTTTATTCCCG	0.473													68	85					2.19297e-23	2.69838e-23	1	0	A	120476539	A	A	120476539	3	1	5	1	0	0	0	0	1	0	0	0	16019	564	20	4	2143	4	TLR4	9	120476539	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2682626	120476539	20736892	263	1399											
DBC1	1620	broad.mit.edu	37	chr9	121930238	121930238	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagctgatgaactgctcgctCcgctccgagtccacgttctg	7	10	10	14	4	1	2	0	2	1	0	5	3	4	2	3	0	3	5	3	0	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:121930238C>T	uc004bkc.2	-	8	1866	c.1410G>A	c.(1408-1410)CGG>CGA	p.R470R		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	470					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						ACTGCTCGCTCCGCTCCGAGT	0.582													29	62					0	0	0	0	T	121930238	T	T	121930238	2	4	5	1	0	0	0	0	0	0	0	1	4264	842	30	2		2	DBC1	9	121930238	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1453699	121930238	19283193	264	1400											
TMEM8C	389827	broad.mit.edu	37	chr9	136380685	136380685	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctatctgctgggtgtagacGctcttgtctgggtacaggcc	5	12	13	11	1	3	1	0	0	3	1	3	1	3	1	2	3	2	4	2	3	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr9:136380685G>A	uc011mdk.1	-	4	444	c.444C>T	c.(442-444)AGC>AGT	p.S148S		NM_001080483	NP_001073952	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	148						integral to membrane					0						GGGTGTAGACGCTCTTGTCTG	0.597													47	68					0	0	0	0	A	136380685	A	A	136380685	2	1	5	1	0	0	0	0	0	0	0	1	16282	1078	38	1		1	TMEM8C	9	136380685	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	14450447	136380685	4832746	265	1401											
GTPBP4	23560	broad.mit.edu	37	chr10	1034450	1034450	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acaacttcaagaaaattacgGtggtgccgtccgccaaggta	13	8	10	10	3	1	1	1	0	0	1	2	1	2	1	3	3	3	1	3	3	7	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:1034450G>T	uc001ift.2	+	1	102	c.31G>T	c.(31-33)GTG>TTG	p.V11L	GTPBP4_uc010qac.1_5'UTR|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_5'UTR|GTPBP4_uc010qae.1_5'Flank	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	11					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		GAAAATTACGGTGGTGCCGTC	0.657													20	5					6.44725e-10	6.97898e-10	1	0	T	1034450	T	T	1034450	3	4	5	1	0	0	0	0	1	0	0	0	6921	1261	44	4	33	4	GTPBP4	10	1034450	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08		1034450	134500297	266	1402											
CUBN	8029	broad.mit.edu	37	chr10	17083215	17083215	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgactattaccacattctcAcatgctggaaaaagaaatga	16	11	6	8	0	1	3	1	2	1	1	2	4	1	4	1	1	2	1	1	1	5	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:17083215A>C	uc001ioo.2	-	27	3886	c.3834T>G	c.(3832-3834)TGT>TGG	p.C1278W		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1278	CUB 8.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCACATTCTCACATGCTGGAA	0.338													65	19					0	0	0	0	C	17083215	C	C	17083215	3	2	5	1	0	0	0	0	1	0	0	0	4068	157	6	5	7201	5	CUBN	10	17083215	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	16048765	17083215	118451532	267	1403											
CUBN	8029	broad.mit.edu	37	chr10	17142060	17142060	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccatttcttaaatgttcaGaatagagatgaaaatagaga	17	12	7	5	0	2	4	1	1	1	3	3	6	3	4	1	0	0	1	1	0	7	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:17142060G>A	uc001ioo.2	-	14	1761	c.1709C>T	c.(1708-1710)TCT>TTT	p.S570F		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	570	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TAAATGTTCAGAATAGAGATG	0.418													105	36					0	0	0	0	A	17142060	A	A	17142060	3	1	5	1	0	0	0	0	1	0	0	0	4068	942	33	2	9378	2	CUBN	10	17142060	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	58845	17142060	118392687	268	1404											
BMI1	648	broad.mit.edu	37	chr10	22607167	22607170	+	5'Flank	DEL	TTTC	-	-																															tgtttgtaaagatgttttttTttctttctttcttgctttct																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:22607167_22607170delTTTC	uc001irh.2	+						COMMD3_uc001ire.2_Intron|COMMD3_uc001irf.2_Intron|COMMD3_uc001irg.2_Intron|BMI1_uc009xkg.2_Intron	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene						hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						GATGTTtttttttctttctttctt	0.27													---	---	---								-	22607170	-	-	22607167	6	5	5	0	1	1	0	1	0	0	0	0	1458	1856	64	0		0	BMI1	10	22607167	5'Flank	DEL	TTTC	TCGA-BA-4078-01A-01D-1434-08	5465107	22607167	112927580	269	1405											
GAD2	2572	broad.mit.edu	37	chr10	26512888	26512888	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagcagactggctgacatCaacagcaaatactaacatgt	16	7	8	10	0	1	2	1	1	0	1	1	2	1	2	0	1	6	4	0	1	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:26512888C>A	uc001isp.2	+	5	1096	c.593C>A	c.(592-594)TCA>TAA	p.S198*	GAD2_uc001isq.2_Nonsense_Mutation_p.S198*	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	198					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TGGCTGACATCAACAGCAAAT	0.343													40	13					6.97489e-18	8.07753e-18	1	0	A	26512888	A	A	26512888	4	1	5	1	0	0	0	0	0	1	0	0	6214	838	29	2	611	2	GAD2	10	26512888	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3905721	26512888	109021859	270	1406											
RBP3	5949	broad.mit.edu	37	chr10	48388397	48388397	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tagcgctggccggcgacctgGggcaaggtccacacctccgt	6	6	14	15	4	0	0	0	0	0	0	2	1	2	0	5	5	1	2	5	5	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:48388397G>T	uc001jez.2	-	1	2595	c.2481C>A	c.(2479-2481)CCC>CCA	p.P827P		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	827	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CGGCGACCTGGGGCAAGGTCC	0.612													14	8					7.93312e-07	8.37163e-07	1	0	T	48388397	T	T	48388397	2	4	5	1	0	0	0	0	0	0	0	1	13222	1219	43	4		4	RBP3	10	48388397	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	21875509	48388397	87146350	271	1407											
C10orf71	118461	broad.mit.edu	37	chr10	50532657	50532657	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagggaagcaggacttcaGaacacacatttgaaccagaa	17	5	11	8	0	1	4	1	1	0	3	1	7	1	6	1	2	3	1	1	2	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:50532657G>A	uc010qgp.1	+	3	2406	c.2067G>A	c.(2065-2067)CAG>CAA	p.Q689Q		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	689											0						CAGGACTTCAGAACACACATT	0.502													25	11					0	0	0	0	A	50532657	A	A	50532657	2	1	5	1	0	0	0	0	0	0	0	1	1620	933	33	2		2	C10orf71	10	50532657	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2144260	50532657	85002090	272	1408											
A1CF	29974	broad.mit.edu	37	chr10	52573752	52573752	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatcctcgacccaggcctgtGtatgccaaatagccacggcc	9	8	9	15	2	0	0	0	0	0	0	2	1	1	0	6	2	2	1	6	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:52573752G>T	uc001jjj.2	-	10	1400	c.1212C>A	c.(1210-1212)TAC>TAA	p.Y404*	A1CF_uc010qhn.1_Nonsense_Mutation_p.Y404*|A1CF_uc001jji.2_Nonsense_Mutation_p.Y396*|A1CF_uc001jjh.2_Nonsense_Mutation_p.Y404*|A1CF_uc010qho.1_Nonsense_Mutation_p.Y412*|A1CF_uc009xov.2_Nonsense_Mutation_p.Y396*	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	404	Required for nuclear localization.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						CCAGGCCTGTGTATGCCAAAT	0.483													94	30					2.08528e-44	3.02006e-44	1	0	T	52573752	T	T	52573752	4	4	5	1	0	0	0	0	0	1	0	0	2	1372	48	4	588	4	A1CF	10	52573752	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2041095	52573752	82960995	273	1409											
PCDH15	65217	broad.mit.edu	37	chr10	55600188	55600188	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaggcatctccatgccggCgagctccaatggactccact	11	7	9	14	2	1	0	0	0	1	0	4	2	3	1	4	3	2	2	4	3	3	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:55600188C>A	uc001jju.1	-	29	4270	c.3875G>T	c.(3874-3876)CGC>CTC	p.R1292L	PCDH15_uc010qhq.1_Missense_Mutation_p.R1297L|PCDH15_uc010qhr.1_Missense_Mutation_p.R1292L|PCDH15_uc010qhs.1_Missense_Mutation_p.R1304L|PCDH15_uc010qht.1_Missense_Mutation_p.R1299L|PCDH15_uc010qhu.1_Missense_Mutation_p.R1292L|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.R1292L|PCDH15_uc010qhw.1_Missense_Mutation_p.R1255L|PCDH15_uc010qhx.1_Missense_Mutation_p.R1221L|PCDH15_uc010qhy.1_Missense_Mutation_p.R1297L|PCDH15_uc010qhz.1_Missense_Mutation_p.R1292L|PCDH15_uc010qia.1_Missense_Mutation_p.R1270L|PCDH15_uc010qib.1_Missense_Mutation_p.R1270L	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1292	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCCATGCCGGCGAGCTCCAAT	0.448										HNSCC(58;0.16)			76	15					5.32961e-40	7.52837e-40	1	0	A	55600188	A	A	55600188	3	1	5	1	0	0	0	0	1	0	0	0	11565	768	27	3	3631	3	PCDH15	10	55600188	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3026436	55600188	79934559	274	1410											
CTNNA3	29119	broad.mit.edu	37	chr10	69281617	69281617	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgctgacgtttgaaggCtaaataatccaaattttcca	13	13	6	9	1	0	2	0	2	0	0	2	2	2	2	3	1	2	3	3	1	6	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:69281617C>T	uc009xpn.1	-	5	685	c.562G>A	c.(562-564)GCC>ACC	p.A188T	CTNNA3_uc001jmw.2_Missense_Mutation_p.A188T|CTNNA3_uc001jmx.3_Missense_Mutation_p.A188T|CTNNA3_uc009xpo.1_Missense_Mutation_p.A48T|CTNNA3_uc001jna.2_Missense_Mutation_p.A200T	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	188					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CGTTTGAAGGCTAAATAATCC	0.478													43	23					0	0	0	0	T	69281617	T	T	69281617	3	4	5	1	0	0	0	0	1	0	0	0	4031	797	28	4	2181	4	CTNNA3	10	69281617	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	13681429	69281617	66253130	275	1411											
CNNM1	26507	broad.mit.edu	37	chr10	101120594	101120594	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctctgtgaccccacagctGacaatcggaaaaagcagagg	13	6	10	12	1	1	3	0	2	1	1	3	4	2	4	3	2	2	2	3	2	3	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:101120594G>C	uc001kpp.3	+	3	2009	c.1720G>C	c.(1720-1722)GAC>CAC	p.D574H	CNNM1_uc009xwe.2_Missense_Mutation_p.D574H|CNNM1_uc010qpi.1_Missense_Mutation_p.D574H|CNNM1_uc009xwf.2_Missense_Mutation_p.D574H|CNNM1_uc009xwg.2_5'UTR	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	574					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		CCCCACAGCTGACAATCGGAA	0.507													137	58					0	0	0	0	C	101120594	C	C	101120594	3	2	5	1	0	0	0	0	1	0	0	0	3627	1290	45	2	1730	2	CNNM1	10	101120594	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	31838977	101120594	34414153	276	1412											
ABCC2	1244	broad.mit.edu	37	chr10	101591439	101591439	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atattcttcatcatccttgcGtttgtgatgaattctgtggc	7	18	8	8	1	4	2	2	2	2	0	5	2	5	2	1	1	1	1	1	1	2	6	rs139082536	byFrequency	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:101591439G>A	uc001kqf.2	+	22	3094	c.2955G>A	c.(2953-2955)GCG>GCA	p.A985A		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	985	ABC transmembrane type-1 2.|Helical; Name=12; (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCATCCTTGCGTTTGTGATGA	0.433													6	181					0	0	0	0	A	101591439	A	A	101591439	2	1	5	1	0	0	0	0	0	0	0	1	53	1132	40	1		1	ABCC2	10	101591439	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	470845	101591439	33943308	277	1413											
MGEA5	10724	broad.mit.edu	37	chr10	103558944	103558944	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctctgccattttcgcttcAacaatttcactcagtatttg	8	17	4	12	1	4	0	3	0	1	0	6	0	5	0	2	0	2	2	2	0	3	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:103558944A>C	uc001ktv.2	-	9	1907	c.1464T>G	c.(1462-1464)GTT>GTG	p.V488V	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Silent_p.V435V|MGEA5_uc009xws.2_Silent_p.V435V|MGEA5_uc001ktw.2_Silent_p.V488V|MGEA5_uc009xwt.2_Silent_p.V251V	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	488					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TTTTCGCTTCAACAATTTCAC	0.393													204	79					0	0	0	0	C	103558944	C	C	103558944	2	2	5	1	0	0	0	0	0	0	0	1	9608	117	5	5		5	MGEA5	10	103558944	Silent	SNP	A	TCGA-BA-4078-01A-01D-1434-08	1967505	103558944	31975803	278	1414											
NFKB2	4791	broad.mit.edu	37	chr10	104161253	104161253	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaacaccatggagccaccCctgaccccgcccagcccagc	10	2	8	21	1	0	2	0	1	0	1	0	3	0	3	8	1	4	0	8	1	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:104161253C>A	uc001kvb.2	+	20	2536	c.2271C>A	c.(2269-2271)CCC>CCA	p.P757P	NFKB2_uc001kva.2_Silent_p.P757P|NFKB2_uc001kvd.2_Silent_p.P757P|NFKB2_uc009xxc.2_Silent_p.P757P	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	757	ANK 7.		Missing (in truncated form p80HT).|Missing (in truncated form LB40).|Missing (in truncated form EB308).		innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		TGGAGCCACCCCTGACCCCGC	0.597			T	IGH@	B-NHL								32	21					2.75727e-19	3.22878e-19	1	0	A	104161253	A	A	104161253	2	1	5	1	0	0	0	0	0	0	0	1	10430	610	22	4		4	NFKB2	10	104161253	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	602309	104161253	31373494	279	1415											
SORCS1	114815	broad.mit.edu	37	chr10	108427560	108427560	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtcgctcataaccatagtcGctgttaggaaagagccgaga	12	9	11	9	3	1	2	1	0	0	2	3	4	1	3	2	1	2	3	2	1	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:108427560G>T	uc001kym.2	-	17	2198	c.2190C>A	c.(2188-2190)TGC>TGA	p.C730*	SORCS1_uc001kyl.2_Nonsense_Mutation_p.C730*|SORCS1_uc009xxs.2_Nonsense_Mutation_p.C730*|SORCS1_uc001kyn.1_Nonsense_Mutation_p.C730*|SORCS1_uc001kyo.2_Nonsense_Mutation_p.C730*	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	730	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AACCATAGTCGCTGTTAGGAA	0.453													21	4					2.32416e-17	2.67193e-17	1	0	T	108427560	T	T	108427560	4	4	5	1	0	0	0	0	0	1	0	0	14994	1101	38	3	1590	3	SORCS1	10	108427560	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	4266307	108427560	27107187	280	1416											
TCF7L2	6934	broad.mit.edu	37	chr10	114910775	114910775	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggttccctccccatatggtCccaccacatcatacgctaca	10	9	5	17	1	1	0	1	0	0	0	4	0	4	0	5	2	2	2	5	2	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:114910775C>T	uc001lae.3	+	9	1401	c.894C>T	c.(892-894)GTC>GTT	p.V298V	TCF7L2_uc001lac.3_Silent_p.V275V|TCF7L2_uc010qrk.1_Silent_p.V275V|TCF7L2_uc010qrl.1_Silent_p.V275V|TCF7L2_uc010qrm.1_Silent_p.V298V|TCF7L2_uc010qrn.1_Silent_p.V241V|TCF7L2_uc001lad.3_Silent_p.V271V|TCF7L2_uc001lag.3_Silent_p.V322V|TCF7L2_uc001laf.3_Silent_p.V275V|TCF7L2_uc010qro.1_Silent_p.V275V|TCF7L2_uc001lah.2_Silent_p.V280V|TCF7L2_uc010qrp.1_Silent_p.V275V|TCF7L2_uc010qrq.1_Silent_p.V271V|TCF7L2_uc010qrr.1_Silent_p.V213V|TCF7L2_uc010qrs.1_Silent_p.V169V|TCF7L2_uc010qrt.1_Silent_p.V169V|TCF7L2_uc010qru.1_Silent_p.V197V|TCF7L2_uc010qrv.1_Silent_p.V115V|TCF7L2_uc010qrw.1_Silent_p.V2V|TCF7L2_uc010qrx.1_Silent_p.V155V	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	298	Mediates interaction with MAD2L2.|Pro-rich.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		CCCATATGGTCCCACCACATC	0.473													59	19					0	0	0	0	T	114910775	T	T	114910775	2	4	5	1	0	0	0	0	0	0	0	1	15764	842	30	2		2	TCF7L2	10	114910775	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	6483215	114910775	20623972	281	1417											
ATRNL1	26033	broad.mit.edu	37	chr10	117045743	117045743	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagctcatctttgtggagaaGgatggagtcatattggggat	10	13	14	4	0	3	1	2	0	1	1	3	5	3	4	0	5	1	1	0	5	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:117045743G>T	uc001lcg.2	+	15	2637	c.2251G>T	c.(2251-2253)GGA>TGA	p.G751*		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	751	PSI 3.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TTGTGGAGAAGGATGGAGTCA	0.313													35	14					1.15505e-17	1.33275e-17	1	0	T	117045743	T	T	117045743	4	4	5	1	0	0	0	0	0	1	0	0	1209	1001	35	4	2309	4	ATRNL1	10	117045743	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2134968	117045743	18489004	282	1418											
FAM196A	642938	broad.mit.edu	37	chr10	128974408	128974408	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggcactgtcatgtatttgcgGtaggctgctctgcaggacac	7	11	13	10	1	2	0	1	0	1	0	2	1	2	1	0	4	3	6	0	4	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:128974408G>T	uc001lju.1	-	1	293	c.252C>A	c.(250-252)TAC>TAA	p.Y84*	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Nonsense_Mutation_p.Y84*|FAM196A_uc001ljv.1_Nonsense_Mutation_p.Y84*|FAM196A_uc009yap.1_Nonsense_Mutation_p.Y84*	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	84										ovary(2)	2						TGTATTTGCGGTAGGCTGCTC	0.607													68	22					1.55545e-33	2.08496e-33	1	0	T	128974408	T	T	128974408	4	4	5	1	0	0	0	0	0	1	0	0	5556	1256	44	4	1199	4	FAM196A	10	128974408	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	11928665	128974408	6560339	283	1419											
FRG2B	441581	broad.mit.edu	37	chr10	135438990	135438990	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgctgcgcccagtgcaagcCctggaacgtcccctatggtg	6	9	12	14	2	0	0	0	0	0	0	1	1	1	1	4	2	5	2	4	2	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr10:135438990C>T	uc010qvg.1	-	4	503	c.450G>A	c.(448-450)AGG>AGA	p.R150R		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	150						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CAGTGCAAGCCCTGGAACGTC	0.527													11	178					0	0	0	0	T	135438990	T	T	135438990	2	4	5	1	0	0	0	0	0	0	0	1	6081	622	22	4		4	FRG2B	10	135438990	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	6464582	135438990	95757	284	1420											
OR51F1	256892	broad.mit.edu	37	chr11	4790409	4790409	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaaagcaactgctcccaCatgggagacacaggtgctga	14	5	12	10	0	0	3	0	1	0	2	1	5	1	3	1	2	4	3	1	2	3	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:4790409C>A	uc010qyl.1	-	1	739	c.739G>T	c.(739-741)GTG>TTG	p.V247L		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	247						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		ACTGCTCCCACATGGGAGACA	0.488													49	23					4.10826e-27	5.2287e-27	1	0	A	4790409	A	A	4790409	3	1	5	1	0	0	0	0	1	0	0	0	11150	478	17	4	202	4	OR51F1	11	4790409	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08		4790409	130216107	285	1421											
OR52B6	340980	broad.mit.edu	37	chr11	5602862	5602862	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcctcctttctcaagatgcCcgctccaaggccctgagtac	7	9	8	17	2	1	2	1	1	1	1	4	2	3	2	5	1	2	2	5	1	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:5602862C>A	uc010qzi.1	+	1	756	c.756C>A	c.(754-756)GCC>GCA	p.A252A	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	252	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCAAGATGCCCGCTCCAAGG	0.507													146	50					2.72662e-46	3.99481e-46	1	0	A	5602862	A	A	5602862	2	1	5	1	0	0	0	0	0	0	0	1	11167	610	22	4		4	OR52B6	11	5602862	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	812453	5602862	129403654	286	1422											
DNHD1	144132	broad.mit.edu	37	chr11	6592373	6592373	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcgacctcatgcgccggccgGtccgcagccgccctggcact	4	5	13	19	6	1	0	1	0	0	0	2	1	2	0	6	3	2	2	6	3	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:6592373G>A	uc001mdw.3	+	42	14195	c.13631G>A	c.(13630-13632)GGT>GAT	p.G4544D	DNHD1_uc001mea.3_Missense_Mutation_p.G813D|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Missense_Mutation_p.G812D|DNHD1_uc010rao.1_Missense_Mutation_p.G802D|DNHD1_uc009yfg.2_Missense_Mutation_p.G169D	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4544					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GCGCCGGCCGGTCCGCAGCCG	0.706													12	3					0	0	0	0	A	6592373	A	A	6592373	3	1	5	1	0	0	0	0	1	0	0	0	4690	1261	44	4	13798	4	DNHD1	11	6592373	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	989511	6592373	128414143	287	1423											
NLRP10	338322	broad.mit.edu	37	chr11	7982797	7982797	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaccaggagcacctggttgTatctgccattgactcctgct	7	11	9	14	0	1	1	0	1	1	0	2	2	2	2	5	2	3	4	5	2	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:7982797T>C	uc001mfv.1	-	2	379	c.362A>G	c.(361-363)TAC>TGC	p.Y121C		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	121							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CACCTGGTTGTATCTGCCATT	0.557													50	31					0	0	0	0	C	7982797	C	C	7982797	3	2	5	1	0	0	0	0	1	0	0	0	10526	1638	57	5	1609	5	NLRP10	11	7982797	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	1390424	7982797	127023719	288	1424											
FAR1	84188	broad.mit.edu	37	chr11	13716315	13716315	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtttttcttaggatcaaaatGgtttcaatcccagaatacta	13	15	6	7	0	3	1	2	0	1	1	4	2	4	2	1	2	1	2	1	2	7	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:13716315G>A	uc001mld.2	+	2	158	c.3G>A	c.(1-3)ATG>ATA	p.M1I	FAR1_uc009ygp.2_Missense_Mutation_p.M1I	NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	1					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						GGATCAAAATGGTTTCAATCC	0.373													42	21					0	0	0	0	A	13716315	A	A	13716315	3	1	5	1	0	0	0	0	1	0	0	0	5706	1348	47	4	5	4	FAR1	11	13716315	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	5733518	13716315	121290201	289	1425											
ABTB2	25841	broad.mit.edu	37	chr11	34219030	34219030	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcgggcagggctggcaccCgggcacagggggtgacgccc	5	3	20	13	3	0	1	0	1	0	0	0	1	0	1	2	7	0	4	2	7	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:34219030C>T	uc001mvl.1	-	3	758	c.528G>A	c.(526-528)CCG>CCA	p.P176P		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	176							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				GGCTGGCACCCGGGCACAGGG	0.672													23	11					0	0	0	0	T	34219030	T	T	34219030	2	4	5	1	0	0	0	0	0	0	0	1	103	639	23	1		1	ABTB2	11	34219030	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	20502715	34219030	100787486	290	1426											
LRRC4C	57689	broad.mit.edu	37	chr11	40136241	40136241	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccatgagtgtgatggcCacaaaacacccaatgatgat	14	7	10	10	0	0	4	0	4	0	0	0	4	0	4	3	1	2	1	3	1	3	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:40136241C>A	uc001mxa.1	-	2	3566	c.1602G>T	c.(1600-1602)GTG>GTT	p.V534V	LRRC4C_uc001mxc.1_Silent_p.V530V|LRRC4C_uc001mxd.1_Silent_p.V530V|LRRC4C_uc001mxb.1_Silent_p.V530V	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	534	Helical; (Potential).				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTGTGATGGCCACAAAACACC	0.463													61	16					1.74971e-23	2.16141e-23	1	0	A	40136241	A	A	40136241	2	1	5	1	0	0	0	0	0	0	0	1	9058	581	21	4		4	LRRC4C	11	40136241	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5917211	40136241	94870275	291	1427											
PHF21A	51317	broad.mit.edu	37	chr11	45970965	45970965	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtaatacctctggctcaaaGactgctccactgtagaccgg	11	9	9	12	1	2	2	1	0	1	2	3	2	3	2	3	2	2	4	3	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:45970965G>A	uc001ncc.3	-	12	1836	c.1212C>T	c.(1210-1212)GTC>GTT	p.V404V	PHF21A_uc001ncb.3_Silent_p.V405V|PHF21A_uc009ykx.2_Silent_p.V405V|PHF21A_uc001nce.2_Silent_p.V405V|PHF21A_uc001nca.1_Silent_p.V140V	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	404					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						CTGGCTCAAAGACTGCTCCAC	0.458													103	540					0	0	0	0	A	45970965	A	A	45970965	2	1	5	1	0	0	0	0	0	0	0	1	11888	929	33	2		2	PHF21A	11	45970965	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	5834724	45970965	89035551	292	1428											
OR4C3	256144	broad.mit.edu	37	chr11	48347133	48347133	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccctttgctggaagttgcctGcaccaatacgtatgtcattg	8	13	9	11	1	1	0	1	0	0	0	1	1	1	1	3	1	4	4	3	1	4	5	rs139158085		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:48347133G>T	uc010rhv.1	+	1	641	c.641G>T	c.(640-642)TGC>TTC	p.C214F		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAAGTTGCCTGCACCAATACG	0.502													60	91					2.44813e-32	3.24018e-32	1	0	T	48347133	T	T	48347133	3	4	5	1	0	0	0	0	1	0	0	0	11104	1319	46	4	643	4	OR4C3	11	48347133	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2376168	48347133	86659383	293	1429											
FOLH1	2346	broad.mit.edu	37	chr11	49197499	49197499	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctatctggtggtgctgagcCacccatttttctattggaca	7	14	10	10	0	2	1	0	1	2	0	2	2	2	2	2	3	2	2	2	3	2	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:49197499C>A	uc001ngy.2	-	8	1192	c.931G>T	c.(931-933)GGC>TGC	p.G311C	FOLH1_uc001ngz.2_Missense_Mutation_p.G311C|FOLH1_uc009yly.2_Missense_Mutation_p.G296C|FOLH1_uc009ylz.2_Missense_Mutation_p.G296C|FOLH1_uc009yma.2_Missense_Mutation_p.G3C	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	311	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GGTGCTGAGCCACCCATTTTT	0.393													62	88					8.52622e-23	1.04301e-22	1	0	A	49197499	A	A	49197499	3	1	5	1	0	0	0	0	1	0	0	0	6011	594	21	4	1369	4	FOLH1	11	49197499	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	850366	49197499	85809017	294	1430											
FOLH1	2346	broad.mit.edu	37	chr11	49207359	49207359	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agcaaagtagtcagcagggtCggagtagagaatgactcctt	13	8	13	7	1	1	2	1	1	0	1	3	4	2	3	1	2	2	4	1	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:49207359C>G	uc001ngy.2	-	6	949	c.688G>C	c.(688-690)GAC>CAC	p.D230H	FOLH1_uc001ngz.2_Missense_Mutation_p.D230H|FOLH1_uc009yly.2_Missense_Mutation_p.D215H|FOLH1_uc009ylz.2_Missense_Mutation_p.D215H|FOLH1_uc009yma.2_Intron	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	230	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TCAGCAGGGTCGGAGTAGAGA	0.458													28	53					0	0	0	0	G	49207359	G	G	49207359	3	3	5	1	0	0	0	0	1	0	0	0	6011	884	31	3	1620	3	FOLH1	11	49207359	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	9860	49207359	85799157	295	1431											
OR8K5	219453	broad.mit.edu	37	chr11	55927730	55927730	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaaggggaatctgcagctCaggccgccttgtgagttcca	11	8	12	10	1	2	1	1	1	1	0	3	2	3	2	3	3	2	3	3	3	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:55927730C>T	uc010rja.1	-	1	64	c.64G>A	c.(64-66)GAG>AAG	p.E22K		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ATCTGCAGCTCAGGCCGCCTT	0.453													75	120					0	0	0	0	T	55927730	T	T	55927730	3	4	5	1	0	0	0	0	1	0	0	0	11299	835	29	2	862	2	OR8K5	11	55927730	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	6720371	55927730	79078786	296	1432											
OR5J2	282775	broad.mit.edu	37	chr11	55944604	55944604	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagactgtccttttgtaggCtaaatgctgtcagccacttc	8	13	10	10	0	1	1	1	0	0	1	3	2	2	1	2	2	2	3	2	2	3	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:55944604C>T	uc010rjb.1	+	1	511	c.511C>T	c.(511-513)CTA>TTA	p.L171L		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					CTTTTGTAGGCTAAATGCTGT	0.438													73	114					0	0	0	0	T	55944604	T	T	55944604	2	4	5	1	0	0	0	0	0	0	0	1	11219	796	28	4		4	OR5J2	11	55944604	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	16874	55944604	79061912	297	1433											
OR5M8	219484	broad.mit.edu	37	chr11	56258412	56258412	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccatacacataaggcacCgtgatgaggaaggagcacac	14	5	11	11	1	0	2	0	2	0	0	1	4	1	4	2	3	2	3	2	3	3	2	rs147351186		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:56258412C>A	uc001nix.1	-	1	435	c.435G>T	c.(433-435)ACG>ACT	p.T145T		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					CATAAGGCACCGTGATGAGGA	0.517													43	83					6.5261e-18	7.57172e-18	1	0	A	56258412	A	A	56258412	2	1	5	1	0	0	0	0	0	0	0	1	11230	639	23	3		3	OR5M8	11	56258412	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	313808	56258412	78748104	298	1434											
OR5M10	390167	broad.mit.edu	37	chr11	56344286	56344286	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaaaggattttcccctaatCatttgttgtatggcaaggat	12	14	8	7	0	1	0	1	0	0	0	2	2	2	2	2	3	0	3	2	3	5	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:56344286C>T	uc001niz.1	-	1	912	c.912G>A	c.(910-912)ATG>ATA	p.M304I		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCCCCTAATCATTTGTTGTA	0.373													159	217					0	0	0	0	T	56344286	T	T	56344286	3	4	5	1	0	0	0	0	1	0	0	0	11227	826	29	2	39	2	OR5M10	11	56344286	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	85874	56344286	78662230	299	1435											
PRG2	5553	broad.mit.edu	37	chr11	57156719	57156719	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggggtctcctccatctcctGctctggtgtctcctcatcct	3	14	8	16	0	5	0	1	0	4	0	10	0	7	0	5	3	1	1	5	3	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:57156719G>T	uc001njz.2	-	2	157	c.130C>A	c.(130-132)CAG>AAG	p.Q44K	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.Q44K|PRG2_uc001nkb.2_Missense_Mutation_p.Q44K|PRG2_uc001nkd.2_Missense_Mutation_p.Q44K|PRG2_uc001nkc.2_Missense_Mutation_p.Q44K|PRG2_uc001nke.2_Missense_Mutation_p.Q324K	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	44					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	TCCATCTCCTGCTCTGGTGTC	0.562													74	86					4.60868e-44	6.65933e-44	1	0	T	57156719	T	T	57156719	3	4	5	1	0	0	0	0	1	0	0	0	12541	1328	46	4	554	4	PRG2	11	57156719	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	812433	57156719	77849797	300	1436											
CTNND1	1500	broad.mit.edu	37	chr11	57569636	57569636	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcgattgcttcgaaaggCtcgtgatatggaccttactg	8	13	12	8	3	0	1	0	1	0	0	2	4	0	2	1	2	3	2	1	2	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:57569636C>A	uc001nmc.3	+	7	1959	c.1388C>A	c.(1387-1389)GCT>GAT	p.A463D	CTNND1_uc001nlh.1_Missense_Mutation_p.A463D|CTNND1_uc001nlu.3_Missense_Mutation_p.A362D|CTNND1_uc001nlt.3_Missense_Mutation_p.A362D|CTNND1_uc001nls.3_Missense_Mutation_p.A362D|CTNND1_uc001nlw.3_Missense_Mutation_p.A362D|CTNND1_uc001nmf.3_Missense_Mutation_p.A463D|CTNND1_uc001nmd.3_Missense_Mutation_p.A409D|CTNND1_uc001nlk.3_Missense_Mutation_p.A409D|CTNND1_uc001nme.3_Missense_Mutation_p.A463D|CTNND1_uc001nll.3_Missense_Mutation_p.A409D|CTNND1_uc001nmg.3_Missense_Mutation_p.A409D|CTNND1_uc001nlj.3_Missense_Mutation_p.A409D|CTNND1_uc001nlr.3_Missense_Mutation_p.A409D|CTNND1_uc001nlp.3_Missense_Mutation_p.A409D|CTNND1_uc001nlx.3_Missense_Mutation_p.A140D|CTNND1_uc001nlz.3_Missense_Mutation_p.A140D|CTNND1_uc009ymn.2_Missense_Mutation_p.A140D|CTNND1_uc001nlm.3_Missense_Mutation_p.A463D|CTNND1_uc001nly.3_Missense_Mutation_p.A140D|CTNND1_uc001nmb.3_Missense_Mutation_p.A140D|CTNND1_uc001nma.3_Missense_Mutation_p.A140D|CTNND1_uc001nmi.3_Missense_Mutation_p.A362D|CTNND1_uc001nmh.3_Missense_Mutation_p.A463D|CTNND1_uc001nlq.3_Missense_Mutation_p.A362D|CTNND1_uc001nln.3_Missense_Mutation_p.A463D|CTNND1_uc001nli.3_Missense_Mutation_p.A463D|CTNND1_uc001nlo.3_Missense_Mutation_p.A362D|CTNND1_uc001nlv.3_Missense_Mutation_p.A362D	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	463	ARM 3.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				CTTCGAAAGGCTCGTGATATG	0.443													160	294					2.83121e-50	4.20674e-50	1	0	A	57569636	A	A	57569636	3	1	5	1	0	0	0	0	1	0	0	0	4036	797	28	4	1406	4	CTNND1	11	57569636	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	412917	57569636	77436880	301	1437											
OR5AN1	390195	broad.mit.edu	37	chr11	59132216	59132216	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacagcaaactatcactttTgttggttgtattattcagta	12	16	7	6	0	2	0	2	0	0	0	2	1	2	0	0	1	3	5	0	1	6	9			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:59132216T>C	uc010rks.1	+	1	285	c.285T>C	c.(283-285)TTT>TTC	p.F95F		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTATCACTTTTGTTGGTTGTA	0.423													158	229					0	0	0	0	C	59132216	C	C	59132216	2	2	5	1	0	0	0	0	0	0	0	1	11197	1809	63	5		5	OR5AN1	11	59132216	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	1562580	59132216	75874300	302	1438											
OR5A2	219981	broad.mit.edu	37	chr11	59189575	59189576	+	Missense_Mutation	DNP	GG	TT	TT																															tagatgatgggattcaccacGgggatcaccaaggcatagaa																								rs150394868		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:59189575_59189576GG>TT	uc010rkt.1	-	1	851_852	c.851_852CC>AA	c.(850-852)CCC>CAA	p.P284Q		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GATTCACCACGGGGATCACCAA	0.475													55	66					0	0	0	0	TT	59189576	TT	TT	59189575	3	4	5	1	0	0	0	0	1	0	0	0	11194	1103	39	3	124	3	OR5A2	11	59189575	Missense_Mutation	DNP	GG	TCGA-BA-4078-01A-01D-1434-08	57359	59189575	75816941	303	1439											
SLC15A3	51296	broad.mit.edu	37	chr11	60718768	60718768	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagccgcccacgggcgccaGcaggtaggaggcgcccagga	8	1	16	16	4	0	0	0	0	0	0	0	2	0	2	5	5	2	2	5	5	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:60718768G>A	uc001nqn.2	-	1	490	c.256C>T	c.(256-258)CTG>TTG	p.L86L	SLC15A3_uc001nqo.2_Silent_p.L86L	NM_016582	NP_057666	Q8IY34	S15A3_HUMAN	solute carrier family 15, member 3	86	Helical; (Potential).				oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0						ACGGGCGCCAGCAGGTAGGAG	0.716													4	4					0	0	0	0	A	60718768	A	A	60718768	2	1	5	1	0	0	0	0	0	0	0	1	14465	962	34	4		4	SLC15A3	11	60718768	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1529193	60718768	74287748	304	1440											
SCGB2A1	4246	broad.mit.edu	37	chr11	61977990	61977990	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agagttcatagacagtgatgCcgctgcagaggctatgggga	11	8	15	7	1	1	4	1	1	0	3	1	5	1	5	1	3	2	4	1	3	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:61977990C>T	uc001nta.2	+	2	225	c.161C>T	c.(160-162)GCC>GTC	p.A54V		NM_002407	NP_002398	O75556	SG2A1_HUMAN	secretoglobin, family 2A, member 1 precursor	54						extracellular region	androgen binding				0						GACAGTGATGCCGCTGCAGAG	0.428													5	250					0	0	0	0	T	61977990	T	T	61977990	3	4	5	1	0	0	0	0	1	0	0	0	13964	739	26	4	167	4	SCGB2A1	11	61977990	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1259222	61977990	73028526	305	1441											
POLR2G	5436	broad.mit.edu	37	chr11	62533149	62533149	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgattcagcaggacgatGagatccgcttaaagattgtg	11	12	12	6	2	1	3	1	2	0	2	2	6	2	4	1	1	1	2	1	1	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:62533149G>T	uc001nva.2	+	6	534	c.424G>T	c.(424-426)GAG>TAG	p.E142*	POLR2G_uc001nvb.2_RNA	NM_002696	NP_002687	P62487	RPB7_HUMAN	DNA directed RNA polymerase II polypeptide G	142					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|protein binding|RNA binding				0						GCAGGACGATGAGATCCGCTT	0.468													67	100					3.41413e-29	4.41664e-29	1	0	T	62533149	T	T	62533149	4	4	5	1	0	0	0	0	0	1	0	0	12275	1291	45	2	446	2	POLR2G	11	62533149	Nonsense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	555159	62533149	72473367	306	1442											
ATG2A	23130	broad.mit.edu	37	chr11	64668018	64668018	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccgcccgctgccccccTgcgtgcgccatgagttctgg	2	8	13	18	4	1	1	0	1	1	0	1	1	1	1	6	1	4	3	6	1	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:64668018T>C	uc001obx.2	-	31	4527	c.4412A>G	c.(4411-4413)CAG>CGG	p.Q1471R	ATG2A_uc001obw.2_Missense_Mutation_p.Q236R	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1471							protein binding			ovary(1)|central_nervous_system(1)	2						GCTGCCCCCCTGCGTGCGCCA	0.637													69	102					0	0	0	0	C	64668018	C	C	64668018	3	2	5	1	0	0	0	0	1	0	0	0	1095	1580	55	5	1448	5	ATG2A	11	64668018	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	2134869	64668018	70338498	307	1443											
DKFZp761E198	91056	broad.mit.edu	37	chr11	65546371	65546371	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagagcttcatccctgccCggcctggacaccaccacctg	9	6	8	18	1	1	1	1	0	0	1	2	2	2	2	6	2	2	1	6	2	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:65546371C>G	uc001ofo.3	-	1	1452	c.1422G>C	c.(1420-1422)CCG>CCC	p.P474P		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	474							protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		CATCCCTGCCCGGCCTGGACA	0.607													14	14					0	0	0	0	G	65546371	G	G	65546371	2	3	5	1	0	0	0	0	0	0	0	1	4565	639	23	3		3	DKFZp761E198	11	65546371	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	878353	65546371	69460145	308	1444											
RIN1	9610	broad.mit.edu	37	chr11	66103108	66103108	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagtaggcacagatgagcTggactaggtctgggaacatg	11	7	16	7	0	1	2	0	1	1	1	1	4	1	4	0	5	2	4	0	5	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:66103108T>A	uc001ohn.1	-	4	555	c.428A>T	c.(427-429)CAG>CTG	p.Q143L	RIN1_uc010roy.1_5'UTR|RIN1_uc009yrd.1_5'UTR|RIN1_uc010roz.1_Missense_Mutation_p.Q38L|RIN1_uc010rpa.1_Missense_Mutation_p.Q38L	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	143	SH2.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						ACAGATGAGCTGGACTAGGTC	0.642													19	20					0	0	0	0	A	66103108	A	A	66103108	3	1	5	1	0	0	0	0	1	0	0	0	13436	1580	55	5	1951	5	RIN1	11	66103108	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	556737	66103108	68903408	309	1445											
SHANK2	22941	broad.mit.edu	37	chr11	70333064	70333064	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgggtggccccaggcccaCatcctcatcccccaggtctg	5	6	12	18	1	2	0	1	0	1	0	4	0	4	0	6	5	0	0	6	5	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:70333064C>A	uc001oqc.2	-	21	3412	c.3334G>T	c.(3334-3336)GTG>TTG	p.V1112L	SHANK2_uc010rqn.1_Missense_Mutation_p.V524L|SHANK2_uc001opz.2_Missense_Mutation_p.V517L|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	733					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCCAGGCCCACATCCTCATCC	0.692													38	846					5.43694e-19	6.35486e-19	1	0	A	70333064	A	A	70333064	3	1	5	1	0	0	0	0	1	0	0	0	14330	478	17	4	2223	4	SHANK2	11	70333064	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4229956	70333064	64673452	310	1446											
MAP6	4135	broad.mit.edu	37	chr11	75319187	75319187	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgaagggttcgctgtagagGctgcgtattcttctgcgatc	6	14	13	8	3	2	2	0	1	2	1	4	3	2	2	0	2	2	5	0	2	3	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:75319187G>C	uc001owu.2	-	2	1151	c.1086C>G	c.(1084-1086)AGC>AGG	p.S362R	MAP6_uc001owv.2_Missense_Mutation_p.S362R	NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	362	Calmodulin-binding (By similarity).					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					CGCTGTAGAGGCTGCGTATTC	0.512													56	25					0	0	0	0	C	75319187	C	C	75319187	3	2	5	1	0	0	0	0	1	0	0	0	9317	1194	42	4	1371	4	MAP6	11	75319187	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	4986123	75319187	59687329	311	1447											
GRM5	2915	broad.mit.edu	37	chr11	88781022	88781022	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcaaaagtaagactgacaGgatcaacagaaggaccattt	17	9	8	7	0	2	3	2	1	0	2	2	5	2	5	1	2	1	1	1	2	5	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:88781022G>A	uc001pcq.2	-	1	219	c.19C>T	c.(19-21)CTG>TTG	p.L7L	GRM5_uc009yvm.2_Silent_p.L7L|GRM5_uc009yvn.1_Silent_p.L7L	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	7					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AAGACTGACAGGATCAACAGA	0.473													23	16					0	0	0	0	A	88781022	A	A	88781022	2	1	5	1	0	0	0	0	0	0	0	1	6839	991	35	4		4	GRM5	11	88781022	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	13461835	88781022	46225494	312	1448											
MTNR1B	4544	broad.mit.edu	37	chr11	92714792	92714792	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcaatatcactgccatcGccattaaccgctactgctac	10	12	4	15	2	3	0	2	0	1	0	4	0	3	0	3	0	5	2	3	0	5	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:92714792G>C	uc001pdk.1	+	2	506	c.403G>C	c.(403-405)GCC>CCC	p.A135P		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	135	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CACTGCCATCGCCATTAACCG	0.597													48	11					0	0	0	0	C	92714792	C	C	92714792	3	2	5	1	0	0	0	0	1	0	0	0	10005	1087	38	3	409	3	MTNR1B	11	92714792	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3933770	92714792	42291724	313	1449											
MMP10	4319	broad.mit.edu	37	chr11	102647451	102647451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcttcagtgttggctgagtGaaagagccccagggagtggc	9	8	16	8	0	1	3	1	2	0	1	1	4	1	4	2	3	2	3	2	3	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:102647451G>A	uc001phg.1	-	5	701	c.679C>T	c.(679-681)CAC>TAC	p.H227Y		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	227		Zinc 2; catalytic.			collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		TTGGCTGAGTGAAAGAGCCCC	0.463													61	22					0	0	0	0	A	102647451	A	A	102647451	3	1	5	1	0	0	0	0	1	0	0	0	9702	1290	45	2	775	2	MMP10	11	102647451	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	9932659	102647451	32359065	314	1450											
MMP12	4321	broad.mit.edu	37	chr11	102742585	102742585	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgcctgtgttaatcttgcTgaatttcaagggggtaacat	10	14	10	7	0	2	1	1	1	1	0	2	1	2	1	1	2	3	3	1	2	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:102742585T>A	uc001phk.2	-	3	493	c.448A>T	c.(448-450)AGC>TGC	p.S150C		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	150					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TTAATCTTGCTGAATTTCAAG	0.418													30	2					0	0	0	0	A	102742585	A	A	102742585	3	1	5	1	0	0	0	0	1	0	0	0	9704	1580	55	5	995	5	MMP12	11	102742585	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	95134	102742585	32263931	315	1451											
ATM	472	broad.mit.edu	37	chr11	108213984	108213984	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcgaagtggtgttcttgaAtggtgcacaggaactgtccc	9	10	13	9	1	1	1	0	1	1	0	2	3	2	2	1	3	3	2	1	3	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:108213984A>G	uc001pkb.1	+	57	8689	c.8304A>G	c.(8302-8304)GAA>GAG	p.E2768E	ATM_uc009yxr.1_Silent_p.E2768E|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Silent_p.E1420E	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2768	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTGTTCTTGAATGGTGCACAG	0.403			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			158	56					0	0	0	0	G	108213984	G	G	108213984	2	3	5	1	0	0	0	0	0	0	0	1	1111	98	4	5		5	ATM	11	108213984	Silent	SNP	A	TCGA-BA-4078-01A-01D-1434-08	5471399	108213984	26792532	316	1452											
DLAT	1737	broad.mit.edu	37	chr11	111896160	111896160	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagaggtcactccggagaCggcgttggttttggggtgtg	5	11	19	6	3	1	2	1	0	0	2	2	4	2	2	1	7	0	2	1	7	0	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:111896160C>T	uc001pmo.2	+	1	623	c.-36C>T	c.(-38--34)GACGG>GATGG		DLAT_uc009yyk.1_Translation_Start_Site|DLAT_uc010rwr.1_Translation_Start_Site	NM_001931	NP_001922	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase precursor						glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding				0		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	ACTCCGGAGACGGCGTTGGTT	0.642													14	5					0	0	0	0	T	111896160	T	T	111896160	1	4	5	1	0	0	0	0	0	0	0	0	4571	551	19	1		1	DLAT	11	111896160	Translation_Start_Site	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3682176	111896160	23110356	317	1453											
NNMT	4837	broad.mit.edu	37	chr11	114168790	114168790	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgactactcagaccagaaccTgcaggagctggagaagtggc	12	6	13	10	0	1	4	1	1	0	3	1	6	1	5	2	3	4	2	2	3	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:114168790T>A	uc001por.1	+	4	536	c.272T>A	c.(271-273)CTG>CAG	p.L91Q	NNMT_uc001pos.1_Missense_Mutation_p.L91Q	NM_006169	NP_006160	P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	91					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			ovary(1)	1		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	GACCAGAACCTGCAGGAGCTG	0.517													73	24					0	0	0	0	A	114168790	A	A	114168790	3	1	5	1	0	0	0	0	1	0	0	0	10563	1580	55	5	278	5	NNMT	11	114168790	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	2272630	114168790	20837726	318	1454											
TMPRSS13	84000	broad.mit.edu	37	chr11	117785164	117785164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caccccgtcacagcgaacagCgtgcttgggacagctctccc	8	6	10	17	3	2	0	1	0	1	0	3	2	2	1	3	1	5	2	3	1	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:117785164C>T	uc001prs.1	-	4	715	c.622G>A	c.(622-624)GCT>ACT	p.A208T	TMPRSS13_uc009yzr.1_5'UTR|TMPRSS13_uc001prt.1_5'UTR|TMPRSS13_uc001pru.1_Missense_Mutation_p.A208T	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	203	Extracellular (Potential).|SRCR.|LDL-receptor class A.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			pancreas(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		CAGCGAACAGCGTGCTTGGGA	0.567													205	77					0	0	0	0	T	117785164	T	T	117785164	3	4	5	1	0	0	0	0	1	0	0	0	16311	768	27	1	1121	1	TMPRSS13	11	117785164	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3616374	117785164	17221352	319	1455											
BSX	390259	broad.mit.edu	37	chr11	122850115	122850115	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcggcggcggcagtgcttccCcggcagctccgcgtgctgcg	2	6	17	16	7	0	0	0	0	0	0	2	0	2	0	3	4	4	5	3	4	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:122850115C>A	uc010rzs.1	-	2	313	c.313G>T	c.(313-315)GGG>TGG	p.G105W		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	105											0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		CAGTGCTTCCCCGGCAGCTCC	0.667													31	14					4.02929e-09	4.32445e-09	1	0	A	122850115	A	A	122850115	3	1	5	1	0	0	0	0	1	0	0	0	1540	623	22	4	395	4	BSX	11	122850115	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5064951	122850115	12156401	320	1456											
OR8B4	283162	broad.mit.edu	37	chr11	124294721	124294721	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctctggctgttctgataatCccacaaggataaactcagtc	11	11	8	11	0	3	1	1	1	2	0	5	2	4	2	1	2	1	3	1	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:124294721C>A	uc010sak.1	-	1	47	c.47G>T	c.(46-48)GGA>GTA	p.G16V		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TTCTGATAATCCCACAAGGAT	0.473													34	9					6.70999e-13	7.45554e-13	1	0	A	124294721	A	A	124294721	3	1	5	1	0	0	0	0	1	0	0	0	11283	855	30	2	884	2	OR8B4	11	124294721	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1444606	124294721	10711795	321	1457											
C11orf61	79684	broad.mit.edu	37	chr11	124670355	124670355	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcggtctccggggctgccctCgggcctggctcgcccgcggg	0	6	18	17	6	1	0	0	0	1	0	4	0	1	0	4	6	1	2	4	6	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:124670355C>T	uc001qba.1	-						C11orf61_uc001qaz.1_5'Flank|C11orf61_uc010sap.1_5'Flank|uc001qbb.2_RNA	NM_024631	NP_078907	Q6P1R3	CK061_HUMAN	hypothetical protein LOC79684												0	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0079)		GGGCTGCCCTCGGGCCTGGCT	0.756													8	0					0	0	0	0	T	124670355	T	T	124670355	1	4	5	0	1	0	0	0	0	0	0	0	1659	899	31	1		1	C11orf61	11	124670355	5'Flank	SNP	C	TCGA-BA-4078-01A-01D-1434-08	375634	124670355	10336161	322	1458											
KCNJ1	3758	broad.mit.edu	37	chr11	128709976	128709976	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgtatctccacttgaggtCaagtaccgttgtccagatgt	8	15	9	9	1	2	2	1	1	1	1	4	2	3	2	3	1	1	3	3	1	3	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:128709976C>G	uc001qeo.1	-	2	271	c.220G>C	c.(220-222)GAC>CAC	p.D74H	KCNJ1_uc001qep.1_Missense_Mutation_p.D55H|KCNJ1_uc001qeq.1_Missense_Mutation_p.D55H|KCNJ1_uc001qer.1_Missense_Mutation_p.D55H|KCNJ1_uc001qes.1_Missense_Mutation_p.D55H	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	74	Cytoplasmic (By similarity).		D -> Y (in BS2).		excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CACTTGAGGTCAAGTACCGTT	0.433													103	49					0	0	0	0	G	128709976	G	G	128709976	3	3	5	1	0	0	0	0	1	0	0	0	8082	826	29	2	959	2	KCNJ1	11	128709976	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4039621	128709976	6296540	323	1459											
IGSF9B	22997	broad.mit.edu	37	chr11	133802070	133802070	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatggatccccacgggcaCgtaaatcacagggggcatgt	10	6	13	12	2	1	0	1	0	0	0	2	1	2	1	3	4	0	3	3	4	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr11:133802070C>G	uc001qgx.3	-	8	1237	c.1006G>C	c.(1006-1008)GTG>CTG	p.V336L	IGSF9B_uc001qgy.1_Missense_Mutation_p.V178L	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	336	Extracellular (Potential).|Ig-like 4.					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCCACGGGCACGTAAATCACA	0.517													8	2					0	0	0	0	G	133802070	G	G	133802070	3	3	5	1	0	0	0	0	1	0	0	0	7645	536	19	3	3091	3	IGSF9B	11	133802070	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5092094	133802070	1204446	324	1460											
ITFG2	55846	broad.mit.edu	37	chr12	2929961	2929961	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtctcagccaggttgtgcGtatgcaattctactgtgtac	7	14	11	9	1	2	0	1	0	2	0	3	0	2	0	1	1	5	4	1	1	4	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:2929961G>A	uc001qlb.1	+	6	682	c.618G>A	c.(616-618)GCG>GCA	p.A206A	ITFG2_uc010seb.1_Silent_p.A29A|ITFG2_uc010sec.1_RNA	NM_018463	NP_060933	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	206											0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			CAGGTTGTGCGTATGCAATTC	0.562													38	63					0	0	0	0	A	2929961	A	A	2929961	2	1	5	1	0	0	0	0	0	0	0	1	7909	1132	40	1		1	ITFG2	12	2929961	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08		2929961	130921934	325	1461											
CDCA3	83461	broad.mit.edu	37	chr12	6958258	6958258	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccttgtcatggtcctggccTtgctcccatgctcgtcctcc	2	14	8	17	1	1	0	1	0	0	0	7	0	6	0	6	2	2	2	6	2	0	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:6958258T>C	uc001qrg.2	-	6	884	c.756A>G	c.(754-756)CAA>CAG	p.Q252Q	CDCA3_uc001qre.2_Intron|uc001qrf.1_5'Flank	NM_031299	NP_112589	Q99618	CDCA3_HUMAN	cell division cycle associated 3	252					cell division|mitosis	cytosol					0						GGTCCTGGCCTTGCTCCCATG	0.532													50	52					0	0	0	0	C	6958258	C	C	6958258	2	2	5	1	0	0	0	0	0	0	0	1	3102	1606	56	5		5	CDCA3	12	6958258	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	4028297	6958258	126893637	326	1462											
CLSTN3	9746	broad.mit.edu	37	chr12	7294733	7294733	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacagtacagacaccacccAaggtactccgtgtgtaagaa	15	6	8	12	1	0	2	0	0	0	2	1	2	1	2	3	1	3	3	3	1	6	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:7294733A>T	uc001qsr.2	+	10	1816	c.1538A>T	c.(1537-1539)CAA>CTA	p.Q513L	CLSTN3_uc001qss.2_Missense_Mutation_p.Q525L	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	513	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						GACACCACCCAAGGTACTCCG	0.458											OREG0021650	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	20					0	0	0	0	T	7294733	T	T	7294733	3	4	5	1	0	0	0	0	1	0	0	0	3578	130	5	5	1576	5	CLSTN3	12	7294733	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	336475	7294733	126557162	327	1463											
CLEC6A	93978	broad.mit.edu	37	chr12	8630046	8630046	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attcaatatgtgagatgaatAagatttacctatgagtagaa	17	13	8	3	0	1	5	1	3	0	3	1	6	1	5	1	0	1	1	1	0	8	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:8630046A>T	uc001qum.1	+	6	733	c.616A>T	c.(616-618)AAG>TAG	p.K206*		NM_001007033	NP_001007034	Q6EIG7	CLC6A_HUMAN	dectin-2	206	Extracellular (Potential).				defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)	1	Lung SC(5;0.184)					TGAGATGAATAAGATTTACCT	0.358													47	77					0	0	0	0	T	8630046	T	T	8630046	4	4	5	1	0	0	0	0	0	1	0	0	3535	363	13	5	638	5	CLEC6A	12	8630046	Nonsense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	1335313	8630046	125221849	328	1464											
A2M	2	broad.mit.edu	37	chr12	9262518	9262518	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacctgatttcttctgtacCaccaccttgtaggagccctg	7	12	7	15	0	2	1	0	1	2	0	2	2	2	2	6	1	2	2	6	1	2	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:9262518C>T	uc001qvk.1	-	6	731	c.618G>A	c.(616-618)GTG>GTA	p.V206V	A2M_uc009zgk.1_Silent_p.V56V	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	206					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TCTTCTGTACCACCACCTTGT	0.458													127	186					0	0	0	0	T	9262518	T	T	9262518	2	4	5	1	0	0	0	0	0	0	0	1	4	581	21	4		4	A2M	12	9262518	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	632472	9262518	124589377	329	1465											
PIK3C2G	5288	broad.mit.edu	37	chr12	18644453	18644453	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaatacttgtcatcttccTctgaaccctgccctatgtat	9	15	5	12	0	3	1	1	1	2	0	4	1	4	1	3	0	3	2	3	0	6	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:18644453T>G	uc001rdt.2	+	19	2747	c.2631T>G	c.(2629-2631)CCT>CCG	p.P877P	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Silent_p.P918P|PIK3C2G_uc010sic.1_Silent_p.P696P	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	877					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GTCATCTTCCTCTGAACCCTG	0.333													57	85					0	0	0	0	G	18644453	G	G	18644453	2	3	5	1	0	0	0	0	0	0	0	1	11966	1538	54	5		5	PIK3C2G	12	18644453	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	9381935	18644453	115207442	330	1466											
ABCC9	10060	broad.mit.edu	37	chr12	21965011	21965011	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accactgaatagtattggatCctgcagaatgattgaaagtc	14	11	9	7	0	0	4	0	3	0	1	2	5	1	5	2	1	1	2	2	1	5	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:21965011C>A	uc001rfi.1	-	34	4203	c.4183G>T	c.(4183-4185)GAT>TAT	p.D1395Y	ABCC9_uc001rfh.2_Missense_Mutation_p.D1395Y|ABCC9_uc001rfj.1_Missense_Mutation_p.D1359Y	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1395	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGTATTGGATCCTGCAGAATG	0.378													52	113					1.12612e-26	1.42747e-26	1	0	A	21965011	A	A	21965011	3	1	5	1	0	0	0	0	1	0	0	0	59	855	30	2	628	2	ABCC9	12	21965011	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3320558	21965011	111886884	331	1467											
ABCC9	10060	broad.mit.edu	37	chr12	22028605	22028605	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgttggaattcgaataTctatattggataatgtagct	12	16	8	5	1	1	0	0	0	1	0	2	3	1	2	1	2	2	3	1	2	8	9			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:22028605T>C	uc001rfi.1	-	15	2095	c.2075A>G	c.(2074-2076)GAT>GGT	p.D692G	ABCC9_uc001rfh.2_Missense_Mutation_p.D692G|ABCC9_uc001rfj.1_Missense_Mutation_p.D656G	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	692	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AATTCGAATATCTATATTGGA	0.308													42	60					0	0	0	0	C	22028605	C	C	22028605	3	2	5	1	0	0	0	0	1	0	0	0	59	1435	50	5	2812	5	ABCC9	12	22028605	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	63594	22028605	111823290	332	1468											
FGD4	121512	broad.mit.edu	37	chr12	32735204	32735204	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaatggagaaagagatgaaActgccacagctcctgcatca	15	7	10	9	0	1	4	1	2	0	2	2	6	2	4	2	1	4	2	2	1	3	0	rs139620944	by1000genomes	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:32735204A>G	uc001rkz.2	+	4	880	c.403A>G	c.(403-405)ACT>GCT	p.T135A	FGD4_uc001rlc.2_Missense_Mutation_p.T220A|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Missense_Mutation_p.T247A|FGD4_uc001rlb.1_RNA|FGD4_uc001rkx.3_Missense_Mutation_p.T135A	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	135	Actin filament-binding (By similarity).				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					AAGAGATGAAACTGCCACAGC	0.493													38	94					0	0	0	0	G	32735204	G	G	32735204	3	3	5	1	0	0	0	0	1	0	0	0	5867	43	2	5	409	5	FGD4	12	32735204	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	10706599	32735204	101116691	333	1469											
CNTN1	1272	broad.mit.edu	37	chr12	41422960	41422960	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagagatggagaatacgtTgtggaggttcgcgcgcacag	10	7	15	9	4	0	2	0	0	0	2	1	5	0	3	1	3	1	3	1	3	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:41422960T>A	uc001rmm.1	+	23	3032	c.2919T>A	c.(2917-2919)GTT>GTA	p.V973V	CNTN1_uc001rmn.1_Silent_p.V962V	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	973	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GAGAATACGTTGTGGAGGTTC	0.448													148	167					0	0	0	0	A	41422960	A	A	41422960	2	1	5	1	0	0	0	0	0	0	0	1	3655	1799	63	5		5	CNTN1	12	41422960	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	8687756	41422960	92428935	334	1470											
DNAJC22	79962	broad.mit.edu	37	chr12	49745133	49745133	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaaggggcaacaaatgaaGaaatacatcggagttaccag	18	5	11	7	1	0	3	0	1	0	2	1	4	0	4	1	3	3	2	1	3	7	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:49745133G>A	uc001rua.2	+	3	1275	c.874G>A	c.(874-876)GAA>AAA	p.E292K	DNAJC22_uc001rub.2_Missense_Mutation_p.E292K	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	292	J.				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						AACAAATGAAGAAATACATCG	0.522													33	73					0	0	0	0	A	49745133	A	A	49745133	3	1	5	1	0	0	0	0	1	0	0	0	4663	943	33	2	880	2	DNAJC22	12	49745133	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	8322173	49745133	84106762	335	1471											
SLC11A2	4891	broad.mit.edu	37	chr12	51388355	51388355	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agatgtccacagccagtgtcGagttatctttaggaaagagg	12	10	12	7	1	1	2	0	0	1	2	3	4	2	3	2	2	1	1	2	2	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:51388355G>C	uc001rxe.3	-	11	1146	c.1049C>G	c.(1048-1050)TCG>TGG	p.S350W	SLC11A2_uc001rxd.3_Missense_Mutation_p.S199W|SLC11A2_uc001rxc.3_Missense_Mutation_p.S350W|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_5'UTR|SLC11A2_uc010smx.1_Missense_Mutation_p.S346W|SLC11A2_uc001rxh.1_Missense_Mutation_p.S350W|SLC11A2_uc001rxj.1_Missense_Mutation_p.S350W|SLC11A2_uc001rxi.2_Missense_Mutation_p.S350W|SLC11A2_uc001rxk.1_Missense_Mutation_p.S379W|SLC11A2_uc010smy.1_Missense_Mutation_p.S313W	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	350	Extracellular (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						AGCCAGTGTCGAGTTATCTTT	0.403													57	95					0	0	0	0	C	51388355	C	C	51388355	3	2	5	1	0	0	0	0	1	0	0	0	14446	1059	37	3	742	3	SLC11A2	12	51388355	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1643222	51388355	82463540	336	1472											
KRT73	319101	broad.mit.edu	37	chr12	53012037	53012037	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgacggacacacggaccccAaggccacactgccaaacatg	14	2	9	16	3	0	0	0	0	0	0	0	3	0	2	4	3	2	0	4	3	2	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:53012037A>G	uc001sas.2	-	1	307	c.272T>C	c.(271-273)TTG>TCG	p.L91S		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	91	Head.|Gly-rich.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		CACGGACCCCAAGGCCACACT	0.627													111	162					0	0	0	0	G	53012037	G	G	53012037	3	3	5	1	0	0	0	0	1	0	0	0	8525	131	5	5	1386	5	KRT73	12	53012037	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	1623682	53012037	80839858	337	1473											
HOXC13	3229	broad.mit.edu	37	chr12	54338804	54338804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgtggttcccctgcagcccGaggtgagcagctaccggcgc	6	6	14	15	4	0	1	0	1	0	0	1	2	1	1	4	3	5	4	4	3	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:54338804G>A	uc001sei.2	+	2	872	c.757G>A	c.(757-759)GAG>AAG	p.E253K	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	253						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CCTGCAGCCCGAGGTGAGCAG	0.607			T	NUP98	AML								148	213					0	0	0	0	A	54338804	A	A	54338804	3	1	5	1	0	0	0	0	1	0	0	0	7351	1059	37	1	763	1	HOXC13	12	54338804	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1326767	54338804	79513091	338	1474											
AVIL	10677	broad.mit.edu	37	chr12	58197112	58197112	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatctcagtgacaacgaatTggccggtcttattggaacat	11	12	10	8	2	2	2	1	2	2	0	3	4	2	3	1	3	2	0	1	3	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:58197112T>G	uc001sqj.1	-	15	1909	c.1880A>C	c.(1879-1881)CAA>CCA	p.Q627P	AVIL_uc009zqe.1_Missense_Mutation_p.Q620P|AVIL_uc001sqk.1_Missense_Mutation_p.Q205P	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin	627	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					GACAACGAATTGGCCGGTCTT	0.478											OREG0021955	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	139	214					0	0	0	0	G	58197112	G	G	58197112	3	3	5	1	0	0	0	0	1	0	0	0	1229	1812	63	5	599	5	AVIL	12	58197112	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	3858308	58197112	75654783	339	1475											
PTPRB	5787	broad.mit.edu	37	chr12	70928431	70928431	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgtgcatcaagctgttcctCctgtaagagcagagagcagg	10	9	13	9	0	1	2	1	0	0	2	3	3	3	2	2	1	4	6	2	1	2	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:70928431C>T	uc001swb.3	-	29	5581	c.5551G>A	c.(5551-5553)GAG>AAG	p.E1851K	uc001svz.2_Intron|PTPRB_uc010sto.1_Missense_Mutation_p.E1761K|PTPRB_uc010stp.1_Missense_Mutation_p.E1761K|PTPRB_uc001swc.3_Missense_Mutation_p.E2069K|PTPRB_uc001swa.3_Missense_Mutation_p.E1981K	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1851	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGCTGTTCCTCCTGTAAGAGC	0.493													17	18					0	0	0	0	T	70928431	T	T	70928431	3	4	5	1	0	0	0	0	1	0	0	0	12861	869	30	2	458	2	PTPRB	12	70928431	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	12731319	70928431	62923464	340	1476											
OSBPL8	114882	broad.mit.edu	37	chr12	76791585	76791585	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcagaagaactgttcctacCcactgaccatttttttgggt	9	15	7	10	0	1	3	1	1	0	2	2	3	2	3	3	1	2	1	3	1	3	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:76791585C>A	uc001sye.1	-	8	1041	c.561G>T	c.(559-561)TGG>TGT	p.W187C	OSBPL8_uc001syf.1_Missense_Mutation_p.W145C|OSBPL8_uc001syg.1_Missense_Mutation_p.W145C|OSBPL8_uc001syh.1_Missense_Mutation_p.W162C	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	187	PH.				lipid transport		lipid binding			ovary(1)	1						CTGTTCCTACCCACTGACCAT	0.398													48	71					1.00776e-21	1.20472e-21	1	0	A	76791585	A	A	76791585	3	1	5	1	0	0	0	0	1	0	0	0	11337	624	22	4	2176	4	OSBPL8	12	76791585	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5863154	76791585	57060310	341	1477											
DEPDC4	120863	broad.mit.edu	37	chr12	100660775	100660775	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccctgggcccggaagctcgTtctgactgacaagtctacgg	7	8	13	13	3	2	2	0	2	2	0	3	3	2	3	2	3	2	2	2	3	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:100660775T>C	uc001thi.2	-	1	83	c.80A>G	c.(79-81)AAC>AGC	p.N27S	SCYL2_uc009ztw.1_5'Flank|SCYL2_uc001thm.1_5'Flank|SCYL2_uc001thn.2_5'Flank|DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Missense_Mutation_p.N27S|DEPDC4_uc009ztv.1_Missense_Mutation_p.N27S|DEPDC4_uc001thk.1_5'UTR|DEPDC4_uc001thl.1_RNA	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	27					intracellular signal transduction						0						CGGAAGCTCGTTCTGACTGAC	0.602													97	119					0	0	0	0	C	100660775	C	C	100660775	3	2	5	1	0	0	0	0	1	0	0	0	4463	1725	60	5	824	5	DEPDC4	12	100660775	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	23869190	100660775	33191120	342	1478											
SLC5A8	160728	broad.mit.edu	37	chr12	101603501	101603501	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgcccatcaggaagtccttGgaggtctgctggccgccccc	5	7	12	17	2	2	0	1	0	1	0	3	2	3	2	6	4	1	1	6	4	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:101603501G>A	uc001thz.3	-	1	516	c.126C>T	c.(124-126)TCC>TCT	p.S42S		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	42	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						GGAAGTCCTTGGAGGTCTGCT	0.657													25	38					0	0	0	0	A	101603501	A	A	101603501	2	1	5	1	0	0	0	0	0	0	0	1	14735	1335	47	4		4	SLC5A8	12	101603501	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	942726	101603501	32248394	343	1479											
STAB2	55576	broad.mit.edu	37	chr12	104054129	104054129	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatctcggaagcttctggaActcgtcagataccacattgt	10	11	10	10	2	3	1	1	0	2	1	5	4	3	4	1	3	3	1	1	3	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:104054129A>T	uc001tjw.2	+	16	1941	c.1755A>T	c.(1753-1755)GAA>GAT	p.E585D		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	585	Extracellular (Potential).|FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AGCTTCTGGAACTCGTCAGAT	0.438													146	219					0	0	0	0	T	104054129	T	T	104054129	3	4	5	1	0	0	0	0	1	0	0	0	15304	40	2	5	1817	5	STAB2	12	104054129	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	2450628	104054129	29797766	344	1480											
POLR3B	55703	broad.mit.edu	37	chr12	106760311	106760311	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taggtgaaaggccttgtgaaAcagcatatagattcatttaa	15	12	9	5	0	1	3	1	2	0	1	1	3	1	3	1	2	2	1	1	2	6	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:106760311A>G	uc001tlp.2	+	3	345	c.123A>G	c.(121-123)AAA>AAG	p.K41K	POLR3B_uc001tlq.2_5'UTR	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	41					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						GCCTTGTGAAACAGCATATAG	0.318													45	44					0	0	0	0	G	106760311	G	G	106760311	2	3	5	1	0	0	0	0	0	0	0	1	12284	40	2	5		5	POLR3B	12	106760311	Silent	SNP	A	TCGA-BA-4078-01A-01D-1434-08	2706182	106760311	27091584	345	1481											
USP30	84749	broad.mit.edu	37	chr12	109522854	109522854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagcgccgatgcccttccCtctcccagttgttcccgact	4	11	8	18	3	2	0	1	0	1	0	5	2	4	0	5	0	2	2	5	0	0	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:109522854C>T	uc010sxi.1	+	12	1369	c.1265C>T	c.(1264-1266)CCT>CTT	p.P422L	USP30_uc001tnu.3_Missense_Mutation_p.P391L|USP30_uc001tnw.3_Missense_Mutation_p.P139L	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	422	Cytoplasmic (Potential).				ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1						ATGCCCTTCCCTCTCCCAGTT	0.507													250	374					0	0	0	0	T	109522854	T	T	109522854	3	4	5	1	0	0	0	0	1	0	0	0	17129	681	24	4	1311	4	USP30	12	109522854	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2762543	109522854	24329041	346	1482											
ATP6V0A2	23545	broad.mit.edu	37	chr12	124221737	124221737	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatgtgcagctttgacgtGaccaacaagtgcctcattgc	11	10	9	11	1	1	2	1	2	0	0	1	2	1	2	2	0	6	2	2	0	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:124221737G>T	uc001ufr.2	+	9	1205	c.957G>T	c.(955-957)GTG>GTT	p.V319V	ATP6V0A2_uc001ufq.1_Silent_p.V319V	NM_012463	NP_036595	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	319	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		GCTTTGACGTGACCAACAAGT	0.562													51	68					6.17242e-35	8.38065e-35	1	0	T	124221737	T	T	124221737	2	4	5	1	0	0	0	0	0	0	0	1	1171	1277	45	2		2	ATP6V0A2	12	124221737	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	14698883	124221737	9630158	347	1483											
TMEM132D	121256	broad.mit.edu	37	chr12	129559181	129559181	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccgtccctccatgagtcccaTagaagaactgccatagtact	11	9	7	14	1	0	3	0	1	0	2	3	3	3	3	5	0	3	1	5	0	5	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr12:129559181T>G	uc009zyl.1	-	9	2867	c.2539A>C	c.(2539-2541)ATG>CTG	p.M847L	TMEM132D_uc001uia.2_Missense_Mutation_p.M385L	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	847	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ATGAGTCCCATAGAAGAACTG	0.527													62	87					0	0	0	0	G	129559181	G	G	129559181	3	3	5	1	0	0	0	0	1	0	0	0	16113	1406	49	5	764	5	TMEM132D	12	129559181	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	5337444	129559181	4292714	348	1484											
TPTE2	93492	broad.mit.edu	37	chr13	20039644	20039644	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaagttgtcttttttgatgAagcagatgaaaaattcttat	13	17	7	4	0	3	4	1	3	2	1	3	4	3	4	0	0	1	2	0	0	5	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:20039644A>T	uc001umd.2	-	9	784	c.573T>A	c.(571-573)CTT>CTA	p.L191L	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Silent_p.L80L|TPTE2_uc001ume.2_Silent_p.L114L|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	191						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TTTTTTGATGAAGCAGATGAA	0.333													28	11					0	0	0	0	T	20039644	T	T	20039644	2	4	5	1	0	0	0	0	0	0	0	1	16498	233	9	5		5	TPTE2	13	20039644	Silent	SNP	A	TCGA-BA-4078-01A-01D-1434-08		20039644	95130234	349	1485											
RNF17	56163	broad.mit.edu	37	chr13	25362210	25362211	+	Frame_Shift_Ins	INS	-	A	A																															ctaaaagctacattgaagagINSaaaaaaaataatttgaatgc																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:25362210_25362211insA	uc001upr.2	+	7	737_738	c.696_697insA	c.(694-699)GAGAAAfs	p.E232fs	RNF17_uc010tdd.1_Frame_Shift_Ins_p.E91fs|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Frame_Shift_Ins_p.E232fs|RNF17_uc001ups.2_Frame_Shift_Ins_p.E171fs|RNF17_uc001upq.1_Frame_Shift_Ins_p.E232fs	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	232_233					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		ACATTGAAGAGAAAAAAAATAA	0.307													---	---	---								A	25362211	A	A	25362210	7	5	5	1	0	1	1	0	0	0	0	0	13526	933	33	0	722	0	RNF17	13	25362210	Frame_Shift_Ins	INS	-	TCGA-BA-4078-01A-01D-1434-08	5322566	25362210	89807668	350	1486											
ATP8A2	51761	broad.mit.edu	37	chr13	26129169	26129169	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaaatgacactcctgccaTggccaggacatcaaacctta	14	7	8	12	0	1	1	1	1	0	0	2	3	2	3	4	3	2	0	4	3	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:26129169T>A	uc001uqk.2	+	13	1368	c.1226T>A	c.(1225-1227)ATG>AAG	p.M409K	ATP8A2_uc010tdi.1_Missense_Mutation_p.M369K|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.M369K	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	369	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		ACTCCTGCCATGGCCAGGACA	0.418													61	19					0	0	0	0	A	26129169	A	A	26129169	3	1	5	1	0	0	0	0	1	0	0	0	1195	1464	51	5	1276	5	ATP8A2	13	26129169	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	766959	26129169	89040709	351	1487											
RXFP2	122042	broad.mit.edu	37	chr13	32339279	32339279	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctaacaatgtgacattacTgtgagtaaaacttaattatt	15	16	5	5	0	1	2	0	2	1	0	1	2	1	2	0	0	3	1	0	0	7	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:32339279T>A	uc001utt.2	+	4	496	c.425T>A	c.(424-426)CTG>CAG	p.L142Q	RXFP2_uc010aba.2_Missense_Mutation_p.L125Q	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	142	LRR 1.|Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		GTGACATTACTGTGAGTAAAA	0.343													38	12					0	0	0	0	A	32339279	A	A	32339279	3	1	5	1	0	0	0	0	1	0	0	0	13825	1594	55	5	439	5	RXFP2	13	32339279	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	6210110	32339279	82830599	352	1488											
SIAH3	283514	broad.mit.edu	37	chr13	46357979	46357979	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caccacctccaggcggccttCccactggcaggagaacaagg	10	4	11	16	1	0	1	0	0	0	1	2	2	2	1	5	5	1	1	5	5	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:46357979C>A	uc001vap.2	-	2	431	c.349G>T	c.(349-351)GAA>TAA	p.E117*		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	117	SIAH-type; degenerate.				multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						AGGCGGCCTTCCCACTGGCAG	0.562													55	24					4.67498e-28	6.02298e-28	1	0	A	46357979	A	A	46357979	4	1	5	1	0	0	0	0	0	1	0	0	14366	864	30	2	464	2	SIAH3	13	46357979	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	14018700	46357979	68811899	353	1489											
SLITRK5	26050	broad.mit.edu	37	chr13	88329715	88329715	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttcgtgctggtcatgaagcGcaggaagaagaaccagagcg	12	6	14	9	3	1	4	1	1	0	3	2	5	1	5	1	2	4	2	1	2	4	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr13:88329715G>T	uc001vln.2	+	2	2291	c.2072G>T	c.(2071-2073)CGC>CTC	p.R691L	SLITRK5_uc010tic.1_Missense_Mutation_p.R450L	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	691	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GTCATGAAGCGCAGGAAGAAG	0.602													25	18					1.55469e-16	1.7776e-16	1	0	T	88329715	T	T	88329715	3	4	5	1	0	0	0	0	1	0	0	0	14810	1087	38	3	2074	3	SLITRK5	13	88329715	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	41971736	88329715	26840163	354	1490											
OR4K1	79544	broad.mit.edu	37	chr14	20403895	20403895	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctctaattcctggggacttCaacttttcttttttgccatc	6	19	5	11	0	3	0	1	0	2	0	6	1	4	1	2	2	2	0	2	2	2	8			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:20403895C>T	uc001vwj.1	+	1	70	c.70C>T	c.(70-72)CAA>TAA	p.Q24*		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CTGGGGACTTCAACTTTTCTT	0.358													196	326					0	0	0	0	T	20403895	T	T	20403895	4	4	5	1	0	0	0	0	0	1	0	0	11121	827	29	2	72	2	OR4K1	14	20403895	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08		20403895	86945645	355	1491											
OR11G2	390439	broad.mit.edu	37	chr14	20666109	20666109	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaacatctcccaaatgtcCttctgtggatctaggattat	10	14	7	10	0	4	0	1	0	3	0	6	2	5	2	2	2	1	0	2	2	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:20666109C>A	uc010tlb.1	+	1	615	c.615C>A	c.(613-615)TCC>TCA	p.S205S		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	205	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CCCAAATGTCCTTCTGTGGAT	0.443													59	19					8.28887e-21	9.81576e-21	1	0	A	20666109	A	A	20666109	2	1	5	1	0	0	0	0	0	0	0	1	10979	668	24	4		4	OR11G2	14	20666109	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	262214	20666109	86683431	356	1492											
TEP1	7011	broad.mit.edu	37	chr14	20846329	20846329	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catactgtccagccggcccaCagccacaacccccccaggca	10	3	7	21	1	0	0	0	0	0	0	1	0	1	0	7	2	4	1	7	2	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:20846329C>G	uc001vxe.2	-	39	5615	c.5575G>C	c.(5575-5577)GTG>CTG	p.V1859L	TEP1_uc010ahk.2_Missense_Mutation_p.V1202L|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.V1751L|TEP1_uc010tlh.1_Missense_Mutation_p.V197L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1859	WD 6.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGCCGGCCCACAGCCACAACC	0.622													47	15					0	0	0	0	G	20846329	G	G	20846329	3	3	5	1	0	0	0	0	1	0	0	0	15825	478	17	4	2376	4	TEP1	14	20846329	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	180220	20846329	86503211	357	1493											
MYH6	4624	broad.mit.edu	37	chr14	23866242	23866242	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgcggatgccctccagcaCgccattgcagcgcagctggt	7	7	13	14	3	0	0	0	0	0	0	1	2	1	1	3	2	6	4	3	2	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:23866242C>T	uc001wjv.2	-	18	2165	c.2098G>A	c.(2098-2100)GTG>ATG	p.V700M		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	700	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCCTCCAGCACGCCATTGCAG	0.617													43	13					0	0	0	0	T	23866242	T	T	23866242	3	4	5	1	0	0	0	0	1	0	0	0	10091	536	19	1	3809	1	MYH6	14	23866242	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3019913	23866242	83483298	358	1494											
NPAS3	64067	broad.mit.edu	37	chr14	34247672	34247672	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctgtgttcttctctttgtagGattagtgattatatggatct	7	20	9	5	0	3	1	0	1	3	0	4	3	3	3	0	2	0	2	0	2	4	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:34247672G>C	uc001wru.2	+	9	1111	c.1047G>C	c.(1045-1047)AGG>AGC	p.R349S	NPAS3_uc001wrs.2_Missense_Mutation_p.R336S|NPAS3_uc001wrt.2_Missense_Mutation_p.R317S|NPAS3_uc001wrv.2_Missense_Mutation_p.R319S	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	349	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CTCTTTGTAGGATTAGTGATT	0.403													63	19					0	0	0	0	C	34247672	C	C	34247672	3	2	5	1	0	0	0	0	1	0	0	0	10618	1188	41	2	1136	2	NPAS3	14	34247672	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	10381430	34247672	73101868	359	1495											
MAP4K5	11183	broad.mit.edu	37	chr14	50912808	50912808	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagctcaccttaggaggtaGgggaggtggtattgcacgtt	8	11	16	6	1	1	0	1	0	0	0	1	2	1	2	1	6	2	6	1	6	4	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:50912808G>A	uc001wya.2	-	17	1494	c.1174C>T	c.(1174-1176)CTA>TTA	p.L392L	MAP4K5_uc001wyb.2_Silent_p.L392L|MAP4K5_uc010anv.1_Silent_p.L392L|MAP4K5_uc001wyc.1_Silent_p.L66L	NM_006575	NP_006566	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase	392					activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(1)	1	all_epithelial(31;0.000415)|Breast(41;0.0102)					TTAGGAGGTAGGGGAGGTGGT	0.274													9	6					0	0	0	0	A	50912808	A	A	50912808	2	1	5	1	0	0	0	0	0	0	0	1	9316	991	35	4		4	MAP4K5	14	50912808	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	16665136	50912808	56436732	360	1496											
FNTB	2342	broad.mit.edu	37	chr14	65453494	65453494	+	5'Flank	DEL	G	-	-																															cagcagctcctctgcccaatGgggggcggcagcatctcagt																								rs3215788		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:65453494delG	uc001xia.2	+						FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|uc001xib.2_5'Flank	NM_002028	NP_002019	P49356	FNTB_HUMAN	farnesyltransferase, CAAX box, beta						protein farnesylation	microtubule associated complex	protein binding|protein farnesyltransferase activity			ovary(1)	1				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		TCTGCCCAATGGGGGGCGGCA	0.557											OREG0022738	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	65453494	-	-	65453494	6	5	5	0	1	1	0	1	0	0	0	0	6010	1363	47	0		0	FNTB	14	65453494	5'Flank	DEL	G	TCGA-BA-4078-01A-01D-1434-08	14540686	65453494	41896046	361	1497											
RGS6	9628	broad.mit.edu	37	chr14	72939588	72939588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttactctttcaggattgaccGgaaaaaagacaagacagaaa	18	8	8	7	1	2	4	1	1	1	3	2	6	2	6	1	2	1	0	1	2	6	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:72939588G>A	uc001xna.3	+	9	1068	c.545G>A	c.(544-546)CGG>CAG	p.R182Q	RGS6_uc010ttn.1_Missense_Mutation_p.R182Q|RGS6_uc001xmx.3_Missense_Mutation_p.R182Q|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.R182Q|RGS6_uc010ttp.1_Missense_Mutation_p.R113Q|RGS6_uc001xmz.1_Missense_Mutation_p.R43Q|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	182					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		AGGATTGACCGGAAAAAAGAC	0.448													125	56					0	0	0	0	A	72939588	A	A	72939588	3	1	5	1	0	0	0	0	1	0	0	0	13374	1116	39	1	575	1	RGS6	14	72939588	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	7486094	72939588	34409952	362	1498											
GALC	2581	broad.mit.edu	37	chr14	88411945	88411945	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttggatgcatcggcagccCatgtaatgggtctctggttg	6	13	14	8	1	1	0	0	0	1	0	3	1	1	1	1	4	2	5	1	4	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:88411945C>T	uc001xvt.2	-	14	2021	c.1622G>A	c.(1621-1623)TGG>TAG	p.W541*	GALC_uc010tvw.1_RNA|GALC_uc010tvx.1_Nonsense_Mutation_p.W515*|GALC_uc010tvy.1_Nonsense_Mutation_p.W518*|GALC_uc010tvz.1_Nonsense_Mutation_p.W485*	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	541					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						ATCGGCAGCCCATGTAATGGG	0.418													57	21					0	0	0	0	T	88411945	T	T	88411945	4	4	5	1	0	0	0	0	0	1	0	0	6236	595	21	4	451	4	GALC	14	88411945	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	15472357	88411945	18937595	363	1499											
TTC8	123016	broad.mit.edu	37	chr14	89338730	89338730	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggctggctctggtcaacaaCaacaaccacgccgaggccta	12	5	10	14	2	2	0	1	0	1	0	2	1	2	0	3	4	4	2	3	4	5	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:89338730C>A	uc010ath.2	+	13	1463	c.1329C>A	c.(1327-1329)AAC>AAA	p.N443K	TTC8_uc001xxl.2_Missense_Mutation_p.N188K|TTC8_uc010ati.2_Missense_Mutation_p.N229K|TTC8_uc001xxm.2_Missense_Mutation_p.N387K|TTC8_uc010atj.2_Missense_Mutation_p.N162K|TTC8_uc001xxi.2_Missense_Mutation_p.N427K|TTC8_uc001xxj.2_Missense_Mutation_p.N417K|TTC8_uc001xxk.2_Missense_Mutation_p.N387K	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	453	TPR 7.				cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						TGGTCAACAACAACAACCACG	0.532									Bardet-Biedl_syndrome				63	18					1.12612e-26	1.42747e-26	1	0	A	89338730	A	A	89338730	3	1	5	1	0	0	0	0	1	0	0	0	16782	477	17	4	1331	4	TTC8	14	89338730	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	926785	89338730	18010810	364	1500											
SLC24A4	123041	broad.mit.edu	37	chr14	92959954	92959954	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttcgtcaacttgccgatGtgccgggaagacgattagcg	9	9	12	11	5	1	1	1	0	0	1	2	4	1	2	3	1	4	0	3	1	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:92959954G>A	uc001yak.2	+	17	1824	c.1800G>A	c.(1798-1800)ATG>ATA	p.M600I	SLC24A4_uc001yai.2_Missense_Mutation_p.M553I|SLC24A4_uc010twm.1_Missense_Mutation_p.M598I|SLC24A4_uc001yaj.2_Missense_Mutation_p.M581I|SLC24A4_uc010auj.2_3'UTR|SLC24A4_uc010twn.1_Missense_Mutation_p.M373I|SLC24A4_uc001yan.2_Missense_Mutation_p.M311I	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	617	Extracellular (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		ACTTGCCGATGTGCCGGGAAG	0.562													25	2					0	0	0	0	A	92959954	A	A	92959954	3	1	5	1	0	0	0	0	1	0	0	0	14532	1377	48	4	1866	4	SLC24A4	14	92959954	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3621224	92959954	14389586	365	1501											
DICER1	23405	broad.mit.edu	37	chr14	95595897	95595897	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cttttcttccaattcctctgGatcacatttcccatttaaaa	10	17	2	12	0	3	0	1	0	2	0	6	1	6	1	3	1	0	0	3	1	3	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:95595897G>A	uc001ydw.2	-	7	828	c.646C>T	c.(646-648)CCA>TCA	p.P216S	DICER1_uc001ydv.2_Missense_Mutation_p.P206S|DICER1_uc001ydx.2_Missense_Mutation_p.P216S	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	216	Helicase ATP-binding.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AATTCCTCTGGATCACATTTC	0.373			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				61	21					0	0	0	0	A	95595897	A	A	95595897	3	1	5	1	0	0	0	0	1	0	0	0	4543	1174	41	2	5210	2	DICER1	14	95595897	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2635943	95595897	11753643	366	1502											
ATG2B	55102	broad.mit.edu	37	chr14	96777573	96777573	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcacaagagtctgagcacgTtctgatatggacaacatcgc	13	8	10	10	2	2	3	0	2	2	1	3	4	2	4	0	1	3	3	0	1	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr14:96777573T>A	uc001yfi.2	-	28	4407	c.4042A>T	c.(4042-4044)ACG>TCG	p.T1348S		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1348										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TCTGAGCACGTTCTGATATGG	0.448													113	33					0	0	0	0	A	96777573	A	A	96777573	3	1	5	1	0	0	0	0	1	0	0	0	1096	1725	60	5	2254	5	ATG2B	14	96777573	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	1181676	96777573	10571967	367	1503											
C15orf2	23742	broad.mit.edu	37	chr15	24921370	24921370	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccgtaaggatccctcctcCcagccgcatgttcactctcc	6	11	6	18	2	2	0	1	0	1	0	7	1	6	1	6	1	1	3	6	1	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:24921370C>T	uc001ywo.2	+	1	830	c.356C>T	c.(355-357)CCC>CTC	p.P119L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	119					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		ATCCCTCCTCCCAGCCGCATG	0.652													71	89					0	0	0	0	T	24921370	T	T	24921370	3	4	5	1	0	0	0	0	1	0	0	0	1790	623	22	4	358	4	C15orf2	15	24921370	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08		24921370	77610022	368	1504											
C15orf2	23742	broad.mit.edu	37	chr15	24922340	24922340	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctcatcctgcctatcccTccactttccaccacaccaaa	9	9	1	22	0	1	0	1	0	0	0	5	0	5	0	9	0	1	0	9	0	2	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:24922340T>G	uc001ywo.2	+	1	1800	c.1326T>G	c.(1324-1326)CCT>CCG	p.P442P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	442	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TGCCTATCCCTCCACTTTCCA	0.527													60	100					0	0	0	0	G	24922340	G	G	24922340	2	3	5	1	0	0	0	0	0	0	0	1	1790	1538	54	5		5	C15orf2	15	24922340	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	970	24922340	77609052	369	1505											
ATP10A	57194	broad.mit.edu	37	chr15	26026341	26026341	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccacgtggatttctttcCagaatcggttcacgtatttc	7	15	7	12	3	2	1	1	0	1	1	6	2	4	2	2	2	0	2	2	2	2	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:26026341C>A	uc010ayu.2	-	2	585	c.479G>T	c.(478-480)TGG>TTG	p.W160L		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	160	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GATTTCTTTCCAGAATCGGTT	0.363													25	26					4.4004e-07	4.65143e-07	1	0	A	26026341	A	A	26026341	3	1	5	1	0	0	0	0	1	0	0	0	1118	595	21	4	4100	4	ATP10A	15	26026341	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1104001	26026341	76505051	370	1506											
BUB1B	701	broad.mit.edu	37	chr15	40488910	40488910	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaagatttatgcaggagtagGggaattctcctttgaagaaa	14	11	12	4	0	1	3	0	1	1	2	2	6	1	5	1	3	1	2	1	3	6	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:40488910G>A	uc001zkx.3	+	9	1435	c.1223G>A	c.(1222-1224)GGG>GAG	p.G408E	BUB1B_uc010ucl.1_Missense_Mutation_p.G271E	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	408					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GCAGGAGTAGGGGAATTCTCC	0.418			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				4	138					0	0	0	0	A	40488910	A	A	40488910	3	1	5	1	0	0	0	0	1	0	0	0	1576	1232	43	4	1257	4	BUB1B	15	40488910	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	14462569	40488910	62042482	371	1507											
ADAL	161823	broad.mit.edu	37	chr15	43627996	43627996	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgatcagatgactgtgattGacaagggaaagaaaagaact	18	7	11	5	1	1	6	1	3	0	3	1	8	1	7	0	1	1	0	0	1	5	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:43627996G>A	uc010udo.1	+	5	740	c.166G>A	c.(166-168)GAC>AAC	p.D56N	ADAL_uc001zrh.2_Missense_Mutation_p.D56N	NM_001159280	NP_001152752	Q6DHV7	ADAL_HUMAN	adenosine deaminase-like isoform 1	56					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding				0		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GACTGTGATTGACAAGGGAAA	0.378													88	110					0	0	0	0	A	43627996	A	A	43627996	3	1	5	1	0	0	0	0	1	0	0	0	233	1290	45	2	172	2	ADAL	15	43627996	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3139086	43627996	58903396	372	1508											
SHF	90525	broad.mit.edu	37	chr15	45460274	45460274	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcgggctgttctggcccagCacatatttgtgttccttggt	4	14	13	10	1	1	0	0	0	1	0	2	0	2	0	2	4	1	4	2	4	1	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:45460274C>G	uc001zuy.2	-	8	1638	c.1143G>C	c.(1141-1143)GTG>GTC	p.V381V	SHF_uc010uen.1_Silent_p.V197V|SHF_uc010ueo.1_Silent_p.V197V|SHF_uc010uep.1_3'UTR|SHF_uc010ueq.1_Silent_p.V157V|SHF_uc010uer.1_3'UTR	NM_138356	NP_612365	Q7M4L6	SHF_HUMAN	Src homology 2 domain containing F	Error:Variant_position_missing_in_B3KTY1_after_alignment										ovary(1)	1		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		TCTGGCCCAGCACATATTTGT	0.572											OREG0023104	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	44					0	0	0	0	G	45460274	G	G	45460274	2	3	5	1	0	0	0	0	0	0	0	1	14342	697	25	4		4	SHF	15	45460274	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1832278	45460274	57071118	373	1509											
SLC24A5	283652	broad.mit.edu	37	chr15	48428997	48428997	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgctgcgcctgtcttgcCaaagctatggagagaagtga	9	10	12	10	1	1	2	0	1	1	1	1	4	1	3	3	1	4	2	3	1	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:48428997C>A	uc001zwe.2	+	6	781	c.708C>A	c.(706-708)GCC>GCA	p.A236A	SLC24A5_uc010bel.2_Silent_p.A176A|uc001zwf.1_5'Flank	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	236	Cytoplasmic (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		CCTGTCTTGCCAAAGCTATGG	0.388													28	36					4.7796e-09	5.121e-09	1	0	A	48428997	A	A	48428997	2	1	5	1	0	0	0	0	0	0	0	1	14533	581	21	4		4	SLC24A5	15	48428997	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2968723	48428997	54102395	374	1510											
ATP8B4	79895	broad.mit.edu	37	chr15	50336882	50336882	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggtcaaggaggaaatttctGgaattagctgaaacaaacat	17	9	10	5	0	2	1	1	1	1	0	2	4	2	4	0	4	3	1	0	4	6	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:50336882G>T	uc001zxu.2	-	5	351	c.209C>A	c.(208-210)CCA>CAA	p.P70Q	ATP8B4_uc010ber.2_5'UTR|ATP8B4_uc010ufd.1_5'UTR|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	70	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GGAAATTTCTGGAATTAGCTG	0.353													22	37					1.10513e-12	1.22576e-12	1	0	T	50336882	T	T	50336882	3	4	5	1	0	0	0	0	1	0	0	0	1199	1348	47	4	3465	4	ATP8B4	15	50336882	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1907885	50336882	52194510	375	1511											
TRPM7	54822	broad.mit.edu	37	chr15	50929755	50929755	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaaacattcaatttgctCagggggttcaataaggtttg	12	14	9	6	0	4	0	4	0	0	0	4	0	4	0	0	3	2	3	0	3	5	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:50929755C>A	uc001zyt.3	-	7	960	c.696G>T	c.(694-696)CTG>CTT	p.L232L	TRPM7_uc010bew.1_Silent_p.L232L	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	232	Cytoplasmic (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TCAATTTGCTCAGGGGGTTCA	0.373													57	57					1.54886e-18	1.80366e-18	1	0	A	50929755	A	A	50929755	2	1	5	1	0	0	0	0	0	0	0	1	16658	813	29	2		2	TRPM7	15	50929755	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	592873	50929755	51601637	376	1512											
UNC13C	440279	broad.mit.edu	37	chr15	54307549	54307549	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtatggaacaaaagcacaCagagtctgagtgggtatgag	15	8	13	5	0	1	3	0	2	1	1	1	4	1	4	0	2	2	3	0	2	6	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:54307549C>A	uc002ack.2	+	1	2449	c.2449C>A	c.(2449-2451)CAG>AAG	p.Q817K		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	817					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CAAAAGCACACAGAGTCTGAG	0.428													33	45					1.60099e-16	1.82721e-16	1	0	A	54307549	A	A	54307549	3	1	5	1	0	0	0	0	1	0	0	0	17054	479	17	4	2451	4	UNC13C	15	54307549	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3377794	54307549	48223843	377	1513											
UNC13C	440279	broad.mit.edu	37	chr15	54307585	54307585	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgaggacagtggctcttcaTtaatggggagatttcggaca	11	11	13	6	1	2	2	1	1	1	1	3	5	2	4	0	5	0	1	0	5	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:54307585T>C	uc002ack.2	+	1	2485	c.2485T>C	c.(2485-2487)TTA>CTA	p.L829L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	829					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGGCTCTTCATTAATGGGGAG	0.428													40	39					0	0	0	0	C	54307585	C	C	54307585	2	2	5	1	0	0	0	0	0	0	0	1	17054	1490	52	5		5	UNC13C	15	54307585	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	36	54307585	48223807	378	1514											
VPS13C	54832	broad.mit.edu	37	chr15	62312738	62312738	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgctttggatcagtgacCtaccaaagaagaaaagataa	16	7	10	8	1	1	4	1	1	0	3	1	5	1	5	3	2	1	1	3	2	6	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:62312738C>A	uc002agz.2	-	9	699	c.625_splice	c.e9-1	p.V209_splice	VPS13C_uc002aha.2_Splice_Site_p.V166_splice|VPS13C_uc002ahb.1_Splice_Site_p.V209_splice|VPS13C_uc002ahc.1_Splice_Site_p.V166_splice	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A						protein localization					ovary(2)	2						GATCAGTGACCTACCAAAGAA	0.403													37	45					8.69298e-16	9.86771e-16	1	0	A	62312738	A	A	62312738	5	1	5	1	0	0	0	0	0	0	1	0	17259	695	24	4	10973	4	VPS13C	15	62312738	Splice_Site	SNP	C	TCGA-BA-4078-01A-01D-1434-08	8005153	62312738	40218654	379	1515											
PLEKHO2	80301	broad.mit.edu	37	chr15	65157206	65157206	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcagtgaagcccaacctcggGagacaccccggcccctcatg	9	5	10	17	2	2	2	2	1	0	1	3	3	2	2	6	2	2	0	6	2	2	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:65157206G>C	uc002anv.2	+	6	726	c.592G>C	c.(592-594)GAG>CAG	p.E198Q	PLEKHO2_uc010bgz.2_Intron|PLEKHO2_uc002anw.2_Missense_Mutation_p.E148Q	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	198	Pro-rich.									ovary(1)|lung(1)	2						CCAACCTCGGGAGACACCCCG	0.622													59	149					0	0	0	0	C	65157206	C	C	65157206	3	2	5	1	0	0	0	0	1	0	0	0	12140	1175	41	2	614	2	PLEKHO2	15	65157206	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2844468	65157206	37374186	380	1516											
DENND4A	10260	broad.mit.edu	37	chr15	65994823	65994823	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatggaagagtacctcttTgcaattttatgggctgattt	9	15	12	5	0	1	2	0	1	1	1	1	4	1	4	1	3	2	3	1	3	4	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:65994823T>G	uc002aph.2	-	17	2628	c.2250A>C	c.(2248-2250)GCA>GCC	p.A750A	DENND4A_uc002api.2_Silent_p.A750A|DENND4A_uc002apj.3_Silent_p.A750A	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	750					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AGTACCTCTTTGCAATTTTAT	0.373													6	4					0	0	0	0	G	65994823	G	G	65994823	2	3	5	1	0	0	0	0	0	0	0	1	4455	1799	63	5		5	DENND4A	15	65994823	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	837617	65994823	36536569	381	1517											
ARID3B	10620	broad.mit.edu	37	chr15	74865224	74865224	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggtggtttggcctggagtGatgatgcagatggaggccgg	7	10	19	5	1	0	3	0	2	0	1	0	5	0	5	2	7	1	2	2	7	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:74865224G>A	uc002aye.2	+	3	775	c.574G>A	c.(574-576)GAT>AAT	p.D192N	ARID3B_uc002ayc.2_Missense_Mutation_p.D192N|ARID3B_uc002ayd.2_Missense_Mutation_p.D192N	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						GGCCTGGAGTGATGATGCAGA	0.473													35	79					0	0	0	0	A	74865224	A	A	74865224	3	1	5	1	0	0	0	0	1	0	0	0	917	1290	45	2	580	2	ARID3B	15	74865224	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	8870401	74865224	27666168	382	1518											
LINGO1	84894	broad.mit.edu	37	chr15	77907035	77907035	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagggaagtccttgaactccTtgccctggacaaactcgggc	9	8	11	13	1	0	1	0	1	0	0	3	3	2	3	3	3	3	0	3	3	3	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:77907035T>A	uc002bct.1	-	2	1266	c.1214A>T	c.(1213-1215)AAG>ATG	p.K405M	LINGO1_uc002bcu.1_Missense_Mutation_p.K399M	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	405	Extracellular (Potential).|LRRCT.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						CTTGAACTCCTTGCCCTGGAC	0.662													7	11					0	0	0	0	A	77907035	A	A	77907035	3	1	5	1	0	0	0	0	1	0	0	0	8856	1609	56	5	652	5	LINGO1	15	77907035	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	3041811	77907035	24624357	383	1519											
BCL2A1	597	broad.mit.edu	37	chr15	80263104	80263104	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatgaactccgcaacaaaatAtgaaatctccttataggtat	16	12	5	8	1	1	2	0	2	1	0	3	2	2	2	2	1	2	2	2	1	10	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:80263104A>G	uc002bfc.3	-	1	540	c.358T>C	c.(358-360)TAT>CAT	p.Y120H	BCL2A1_uc002bfd.3_Missense_Mutation_p.Y120H	NM_004049	NP_004040	Q16548	B2LA1_HUMAN	BCL2-related protein A1 isoform 1	120					anti-apoptosis|apoptosis	cytoplasm	protein binding			pancreas(1)	1						GCAACAAAATATGAAATCTCC	0.388													133	171					0	0	0	0	G	80263104	G	G	80263104	3	3	5	1	0	0	0	0	1	0	0	0	1368	449	16	5	237	5	BCL2A1	15	80263104	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	2356069	80263104	22268288	384	1520											
ACAN	176	broad.mit.edu	37	chr15	89388786	89388786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctttggagtggggggtgagGaggacatcaccgtccagaca	9	8	16	8	1	2	2	1	1	1	1	3	5	3	5	2	6	0	0	2	6	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr15:89388786G>A	uc010upo.1	+	7	1476	c.1102G>A	c.(1102-1104)GAG>AAG	p.E368K	ACAN_uc002bmx.2_Missense_Mutation_p.E368K|ACAN_uc010upp.1_Missense_Mutation_p.E368K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	368					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGGGGGTGAGGAGGACATCAC	0.572													28	38					0	0	0	0	A	89388786	A	A	89388786	3	1	5	1	0	0	0	0	1	0	0	0	117	1175	41	2	1124	2	ACAN	15	89388786	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	9125682	89388786	13142606	385	1521											
HS3ST4	9951	broad.mit.edu	37	chr16	26147209	26147209	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attcgaatagggatctatgcGctgcatctggaaaactggct	11	11	11	8	2	2	0	0	0	2	0	3	3	2	2	0	3	3	3	0	3	5	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:26147209G>T	uc002dof.2	+	2	1403	c.1011G>T	c.(1009-1011)GCG>GCT	p.A337A		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	337	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		GGATCTATGCGCTGCATCTGG	0.557													138	44					1.36653e-54	2.05961e-54	1	0	T	26147209	T	T	26147209	2	4	5	1	0	0	0	0	0	0	0	1	7406	1074	38	3		3	HS3ST4	16	26147209	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08		26147209	64207544	386	1522											
NKD1	85407	broad.mit.edu	37	chr16	50667328	50667328	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcactttgtgaggtcccccaAggcccagggcaagagtgtgg	8	7	15	11	0	0	2	0	1	0	1	1	2	1	2	3	4	0	2	3	4	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:50667328A>G	uc002egg.1	+	10	1273	c.1049A>G	c.(1048-1050)AAG>AGG	p.K350R		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	350					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		AGGTCCCCCAAGGCCCAGGGC	0.662													53	10					0	0	0	0	G	50667328	G	G	50667328	3	3	5	1	0	0	0	0	1	0	0	0	10495	72	3	5	1087	5	NKD1	16	50667328	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	24520119	50667328	39687425	387	1523											
CYLD	1540	broad.mit.edu	37	chr16	50785545	50785545	+	Frame_Shift_Del	DEL	G	-	-																															gtggtcaaggtttcactgacGgggtgtaccaagggaaacag																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:50785545delG	uc002egp.1	+	5	950	c.535delG	c.(535-537)GGGfs	p.G179fs	CYLD_uc002egn.1_Frame_Shift_Del_p.G179fs|CYLD_uc002ego.2_Frame_Shift_Del_p.G179fs|CYLD_uc010cbs.1_Frame_Shift_Del_p.G179fs|CYLD_uc002egq.1_Frame_Shift_Del_p.G179fs|CYLD_uc002egr.1_Frame_Shift_Del_p.G179fs|CYLD_uc002egs.1_Frame_Shift_Del_p.G179fs	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	179	CAP-Gly 1.|Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TTTCACTGACGGGGTGTACCA	0.418			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				---	---	---								-	50785545	-	-	50785545	7	5	5	1	0	1	0	1	0	0	0	0	4160	1116	39	0	541	0	CYLD	16	50785545	Frame_Shift_Del	DEL	G	TCGA-BA-4078-01A-01D-1434-08	118217	50785545	39569208	388	1524											
CAPNS2	84290	broad.mit.edu	37	chr16	55601279	55601279	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctaatgaagatggagataTggattttaacaatttcatca	15	14	8	4	0	2	3	2	1	0	2	2	5	2	4	0	2	2	1	0	2	5	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:55601279T>C	uc002eid.1	+	1	696	c.611T>C	c.(610-612)ATG>ACG	p.M204T	LPCAT2_uc002eie.3_Intron|LPCAT2_uc002eic.2_Intron	NM_032330	NP_115706	Q96L46	CPNS2_HUMAN	calpain small subunit 2	204	EF-hand 3.					cytoplasm|plasma membrane	calcium ion binding				0						GATGGAGATATGGATTTTAAC	0.478													198	66					0	0	0	0	C	55601279	C	C	55601279	3	2	5	1	0	0	0	0	1	0	0	0	2646	1464	51	5	613	5	CAPNS2	16	55601279	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	4815734	55601279	34753474	389	1525											
C16orf70	80262	broad.mit.edu	37	chr16	67168322	67168322	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgagagtgtagatgttcttCgagatggaactggacctgca	10	11	13	7	1	1	3	0	1	1	3	2	7	1	5	1	2	2	3	1	2	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:67168322C>T	uc002erc.2	+	9	697	c.613C>T	c.(613-615)CGA>TGA	p.R205*	C16orf70_uc002erd.2_Nonsense_Mutation_p.R205*|C16orf70_uc002ere.1_3'UTR	NM_025187	NP_079463	Q9BSU1	CP070_HUMAN	lin-10	205										ovary(2)	2		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		AGATGTTCTTCGAGATGGAAC	0.512													246	77					0	0	0	0	T	67168322	T	T	67168322	4	4	5	1	0	0	0	0	0	1	0	0	1835	876	31	1	643	1	C16orf70	16	67168322	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	11567043	67168322	23186431	390	1526											
CENPT	80152	broad.mit.edu	37	chr16	67862385	67862385	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgccttctcaccgccgcatCagcagctccaggtcctctgg	5	8	9	19	3	3	0	2	0	2	0	6	0	5	0	6	2	2	3	6	2	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:67862385C>T	uc002eun.3	-	15	2103	c.1554G>A	c.(1552-1554)CTG>CTA	p.L518L	CENPT_uc002eum.3_Silent_p.L463L|CENPT_uc010vkc.1_3'UTR|CENPT_uc010vkd.1_Silent_p.L271L	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	518					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		ACCGCCGCATCAGCAGCTCCA	0.562													109	31					0	0	0	0	T	67862385	T	T	67862385	2	4	5	1	0	0	0	0	0	0	0	1	3257	813	29	2		2	CENPT	16	67862385	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	694063	67862385	22492368	391	1527											
DDX28	55794	broad.mit.edu	37	chr16	68056395	68056395	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcatgccgtggcctccctcCaggtcccgcaccagcaggcc	5	5	11	20	3	0	0	0	0	0	0	3	0	3	0	7	3	2	3	7	3	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:68056395C>A	uc002evh.1	-	1	1565	c.711G>T	c.(709-711)CTG>CTT	p.L237L	DUS2L_uc002evi.2_5'Flank|DUS2L_uc002evj.2_5'Flank|DUS2L_uc010vkk.1_5'Flank	NM_018380	NP_060850	Q9NUL7	DDX28_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28	237	Helicase ATP-binding.					mitochondrial nucleoid|nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0116)|Epithelial(162;0.0474)|all cancers(182;0.233)		GGCCTCCCTCCAGGTCCCGCA	0.657													30	8					7.68411e-24	9.52951e-24	1	0	A	68056395	A	A	68056395	2	1	5	1	0	0	0	0	0	0	0	1	4372	581	21	4		4	DDX28	16	68056395	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	194010	68056395	22298358	392	1528											
HYDIN	54768	broad.mit.edu	37	chr16	70989378	70989378	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctgttggccacagcttcCagcacaatggagtcgatgct	8	11	11	11	1	0	0	0	0	0	0	2	2	1	1	2	2	4	5	2	2	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:70989378C>A	uc002ezr.2	-	40	6341	c.6213G>T	c.(6211-6213)CTG>CTT	p.L2071L		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2072										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCACAGCTTCCAGCACAATGG	0.557													48	15					2.94884e-30	3.84631e-30	1	0	A	70989378	A	A	70989378	2	1	5	1	0	0	0	0	0	0	0	1	7506	581	21	4		4	HYDIN	16	70989378	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2932983	70989378	19365375	393	1529											
GLG1	2734	broad.mit.edu	37	chr16	74519693	74519693	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accatggagaagataacttaCattgggtctccagatcttat	13	12	8	8	0	2	3	0	0	2	3	3	4	2	3	2	2	2	0	2	2	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr16:74519693C>T	uc002fcy.3	-	9	1621	c.1571_splice	c.e9+1	p.M524_splice	GLG1_uc002fcx.2_Splice_Site_p.M524_splice|GLG1_uc002fcw.3_Splice_Site_p.M513_splice|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3							Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						AGATAACTTACATTGGGTCTC	0.408													68	23					0	0	0	0	T	74519693	T	T	74519693	5	4	5	1	0	0	0	0	0	0	1	0	6473	492	17	4	2119	4	GLG1	16	74519693	Splice_Site	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3530315	74519693	15835060	394	1530											
TP53	7157	broad.mit.edu	37	chr17	7577610	7577610	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtacagtcagagccaaccTaggagataacacaggcccaa	15	5	10	11	0	1	2	1	0	0	2	1	3	1	2	3	3	4	1	3	3	5	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:7577610T>C	uc002gim.2	-	7	867	c.673_splice	c.e7-1	p.V225_splice	TP53_uc002gig.1_Splice_Site_p.V225_splice|TP53_uc002gih.2_Splice_Site_p.V225_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.V93_splice|TP53_uc010cng.1_Splice_Site_p.V93_splice|TP53_uc002gii.1_Splice_Site_p.V93_splice|TP53_uc010cnh.1_Splice_Site_p.V225_splice|TP53_uc010cni.1_Splice_Site_p.V225_splice|TP53_uc002gij.2_Splice_Site_p.V225_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(22)|p.0?(7)|p.V225fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGAGCCAACCTAGGAGATAAC	0.483		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			53	10					0	0	0	0	C	7577610	C	C	7577610	5	2	5	1	0	0	0	0	0	0	1	0	16448	1536	53	5	619	5	TP53	17	7577610	Splice_Site	SNP	T	TCGA-BA-4078-01A-01D-1434-08		7577610	73617600	395	1531											
MYH10	4628	broad.mit.edu	37	chr17	8526248	8526248	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcctgaatagtagcgatccTtcagattatgtaaaacggaa	14	11	9	7	2	1	2	1	1	0	1	3	4	3	3	2	1	2	2	2	1	7	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:8526248T>C	uc002gll.2	-	2	413	c.317A>G	c.(316-318)AAG>AGG	p.K106R	MYH10_uc002glm.2_Missense_Mutation_p.K106R|MYH10_uc010cnx.2_Missense_Mutation_p.K106R	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	106	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GTAGCGATCCTTCAGATTATG	0.343													93	112					0	0	0	0	C	8526248	C	C	8526248	3	2	5	1	0	0	0	0	1	0	0	0	10083	1609	56	5	5773	5	MYH10	17	8526248	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	948638	8526248	72668962	396	1532											
DHRS7C	201140	broad.mit.edu	37	chr17	9683345	9683345	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaacaggaccagctttgggGtgaatgtctgctgaaccaat	11	9	11	10	0	1	2	0	2	1	0	1	3	1	3	3	3	4	2	3	3	4	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:9683345G>T	uc010vvb.1	-	3	278	c.278C>A	c.(277-279)ACC>AAC	p.T93N	DHRS7C_uc010cof.2_Missense_Mutation_p.T92N	NM_001105571	NP_001099041	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	93						extracellular region	binding|oxidoreductase activity				0						CAGCTTTGGGGTGAATGTCTG	0.507													16	31					6.94344e-10	7.50321e-10	1	0	T	9683345	T	T	9683345	3	4	5	1	0	0	0	0	1	0	0	0	4519	1261	44	4	676	4	DHRS7C	17	9683345	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1157097	9683345	71511865	397	1533											
MYH13	8735	broad.mit.edu	37	chr17	10265781	10265781	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gatcttgtcaaatttgggagGgttcatggggaagacctggt	9	12	15	5	0	3	1	2	0	1	1	3	4	3	3	1	5	0	1	1	5	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:10265781G>T	uc002gmk.1	-	4	334	c.244C>A	c.(244-246)CCT>ACT	p.P82T		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	82	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						AATTTGGGAGGGTTCATGGGG	0.478													94	164					1.52783e-54	2.29721e-54	1	0	T	10265781	T	T	10265781	3	4	5	1	0	0	0	0	1	0	0	0	10085	1232	43	4	5724	4	MYH13	17	10265781	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	582436	10265781	70929429	398	1534											
MYH1	4619	broad.mit.edu	37	chr17	10408506	10408506	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaccattttctggtactcCactcttgccaagaaccctct	8	13	4	16	0	3	1	0	0	3	1	5	1	5	1	5	1	3	1	5	1	3	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:10408506C>A	uc002gmo.2	-	21	2503	c.2409G>T	c.(2407-2409)GTG>GTT	p.V803V	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	803	IQ.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCTGGTACTCCACTCTTGCCA	0.433													44	114					1.23713e-20	1.46227e-20	1	0	A	10408506	A	A	10408506	2	1	5	1	0	0	0	0	0	0	0	1	10082	581	21	4		4	MYH1	17	10408506	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	142725	10408506	70786704	399	1535											
DNAH9	1770	broad.mit.edu	37	chr17	11607761	11607761	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagatgattgctcagaaggTgggtcccaaacatccaggga	13	7	12	9	0	1	3	1	1	0	2	3	4	3	4	2	3	2	1	2	3	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:11607761T>C	uc002gne.2	+	25	5459	c.5391_splice	c.e25+2	p.K1797_splice	DNAH9_uc010coo.2_Splice_Site_p.K1091_splice	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCTCAGAAGGTGGGTCCCAAA	0.522													28	55					0	0	0	0	C	11607761	C	C	11607761	5	2	5	1	0	0	0	0	0	0	1	0	4630	1710	59	5	5491	5	DNAH9	17	11607761	Splice_Site	SNP	T	TCGA-BA-4078-01A-01D-1434-08	1199255	11607761	69587449	400	1536											
RAI1	10743	broad.mit.edu	37	chr17	17698946	17698946	+	Frame_Shift_Del	DEL	C	-	-																															ggacccgctgtcacccaaggCcccactcatctgcaccaagg																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:17698946delC	uc002grm.2	+	3	3153	c.2684delC	c.(2683-2685)GCCfs	p.A895fs	RAI1_uc002grn.1_Frame_Shift_Del_p.A895fs	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	895						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		TCACCCAAGGCCCCACTCATC	0.652													---	---	---								-	17698946	-	-	17698946	7	5	5	1	0	1	0	1	0	0	0	0	13072	739	26	0	2686	0	RAI1	17	17698946	Frame_Shift_Del	DEL	C	TCGA-BA-4078-01A-01D-1434-08	6091185	17698946	63496264	401	1537											
MEOX1	4222	broad.mit.edu	37	chr17	41738516	41738516	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	accccgtagtcatcgcctggGcctcctgtggtgtccaccag	5	9	11	16	2	1	0	1	0	0	0	4	0	3	0	7	2	0	1	7	2	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:41738516G>A	uc002idz.2	-	1	416	c.387C>T	c.(385-387)GGC>GGT	p.G129G	MEOX1_uc002iea.2_Silent_p.G129G|MEOX1_uc002ieb.2_Silent_p.G14G	NM_004527	NP_004518	P50221	MEOX1_HUMAN	mesenchyme homeobox 1 isoform 1	129						nucleus	sequence-specific DNA binding				0		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0753)		CATCGCCTGGGCCTCCTGTGG	0.627													150	199					0	0	0	0	A	41738516	A	A	41738516	2	1	5	1	0	0	0	0	0	0	0	1	9526	1190	42	4		4	MEOX1	17	41738516	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	24039570	41738516	39456694	402	1538											
GPATCH8	23131	broad.mit.edu	37	chr17	42476285	42476285	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctttactgtcatctcctcTgccatcatctttcttcccag	5	17	4	15	0	6	0	2	0	4	0	8	0	7	0	3	0	3	1	3	0	1	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:42476285T>A	uc002igw.1	-	8	3224	c.3160A>T	c.(3160-3162)AGA>TGA	p.R1054*	GPATCH8_uc002igv.1_Nonsense_Mutation_p.R976*|GPATCH8_uc010wiz.1_Nonsense_Mutation_p.R976*	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1054						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TCATCTCCTCTGCCATCATCT	0.537													55	65					0	0	0	0	A	42476285	A	A	42476285	4	1	5	1	0	0	0	0	0	1	0	0	6632	1588	55	5	1352	5	GPATCH8	17	42476285	Nonsense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	737769	42476285	38718925	403	1539											
C17orf104	284071	broad.mit.edu	37	chr17	42744329	42744330	+	Frame_Shift_Ins	INS	-	A	A																															attttagtgtccaagatagcINSaaaaaattagccaatggcac																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:42744329_42744330insA	uc010czv.2	+	5	1050_1051	c.1050_1051insA	c.(1048-1053)AGCAAAfs	p.S350fs	C17orf104_uc002igy.1_Frame_Shift_Ins_p.S184fs|C17orf104_uc002igz.3_Frame_Shift_Ins_p.S184fs|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Frame_Shift_Ins_p.S184fs	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	350_351										central_nervous_system(1)	1						TCCAAGATAGCAAAAAATTAGC	0.347													---	---	---								A	42744330	A	A	42744329	7	5	5	1	0	1	1	0	0	0	0	0	1857	709	25	0	1068	0	C17orf104	17	42744329	Frame_Shift_Ins	INS	-	TCGA-BA-4078-01A-01D-1434-08	268044	42744329	38450881	404	1540											
MRC2	9902	broad.mit.edu	37	chr17	60755933	60755933	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagggggcctgccaggagctGggggcccagctgctgagcct	5	5	18	13	0	0	1	0	1	0	0	0	2	0	2	4	5	5	3	4	5	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:60755933G>T	uc002jad.2	+	13	2523	c.2121G>T	c.(2119-2121)CTG>CTT	p.L707L	MRC2_uc010ddq.1_RNA|MRC2_uc002jae.2_5'Flank|MRC2_uc002jaf.2_5'Flank	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	707	Extracellular (Potential).|C-type lectin 4.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GCCAGGAGCTGGGGGCCCAGC	0.627													20	31					3.01185e-09	3.24353e-09	1	0	T	60755933	T	T	60755933	2	4	5	1	0	0	0	0	0	0	0	1	9811	1335	47	4		4	MRC2	17	60755933	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	18011604	60755933	20439277	405	1541											
TANC2	26115	broad.mit.edu	37	chr17	61489388	61489388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtagatcatggggccatGatcgagcacgttgactacag	10	9	13	9	2	1	3	1	2	0	1	2	4	1	3	1	3	2	3	1	3	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:61489388G>A	uc002jal.3	+	21	3596	c.3573G>A	c.(3571-3573)ATG>ATA	p.M1191I	TANC2_uc010wpe.1_Missense_Mutation_p.M1101I|TANC2_uc002jao.3_Missense_Mutation_p.M292I	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1191	ANK 10.						binding			ovary(2)	2						ATGGGGCCATGATCGAGCACG	0.542													43	41					0	0	0	0	A	61489388	A	A	61489388	3	1	5	1	0	0	0	0	1	0	0	0	15611	1290	45	2	3655	2	TANC2	17	61489388	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	733455	61489388	19705822	406	1542											
DDX42	11325	broad.mit.edu	37	chr17	61893008	61893008	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggcctaggctacagggagcGgcctggcctgggctctgaga	7	6	17	11	1	1	1	0	1	1	1	1	3	1	2	3	6	2	2	3	6	2	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:61893008G>T	uc002jbu.2	+	17	2245	c.1988G>T	c.(1987-1989)CGG>CTG	p.R663L	DDX42_uc002jbv.2_Missense_Mutation_p.R663L|DDX42_uc002jbx.2_Missense_Mutation_p.R399L|DDX42_uc002jby.2_Missense_Mutation_p.R209L|DDX42_uc010wps.1_Missense_Mutation_p.R31L	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	663					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						TACAGGGAGCGGCCTGGCCTG	0.463													47	101					2.74695e-27	3.5103e-27	1	0	T	61893008	T	T	61893008	3	4	5	1	0	0	0	0	1	0	0	0	4379	1116	39	3	2046	3	DDX42	17	61893008	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	403620	61893008	19302202	407	1543											
TEX2	55852	broad.mit.edu	37	chr17	62291206	62291206	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcactgtacttaatacttgTgctgctggaacaggggactc	9	11	12	9	0	0	0	0	0	0	0	1	2	0	2	0	4	5	4	0	4	4	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:62291206T>C	uc002jec.2	-	2	545	c.372A>G	c.(370-372)GCA>GCG	p.A124A	TEX2_uc002jed.2_Silent_p.A124A|TEX2_uc002jee.2_Silent_p.A124A	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	124					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TTAATACTTGTGCTGCTGGAA	0.562													107	118					0	0	0	0	C	62291206	C	C	62291206	2	2	5	1	0	0	0	0	0	0	0	1	15847	1683	59	5		5	TEX2	17	62291206	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	398198	62291206	18904004	408	1544											
ABCA9	10350	broad.mit.edu	37	chr17	67041454	67041454	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatccatgcttttttcatCaggccaccccatgattgttc	7	16	5	13	0	3	1	3	1	0	0	5	1	4	1	4	1	1	2	4	1	0	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:67041454C>G	uc002jhu.2	-	4	471	c.328G>C	c.(328-330)GAT>CAT	p.D110H	ABCA9_uc010dez.2_Missense_Mutation_p.D110H|ABCA9_uc002jhv.2_Missense_Mutation_p.D110H	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	110					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CTTTTTTCATCAGGCCACCCC	0.378													61	123					0	0	0	0	G	67041454	G	G	67041454	3	3	5	1	0	0	0	0	1	0	0	0	39	826	29	2	4690	2	ABCA9	17	67041454	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4750248	67041454	14153756	409	1545											
TRIM47	91107	broad.mit.edu	37	chr17	73871028	73871028	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccctcgataatctccacctCccagtagtaggtgcctcggt	7	10	9	15	2	1	0	0	0	1	0	5	1	2	0	5	2	1	2	5	2	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:73871028C>A	uc002jpw.2	-	6	1480	c.1453G>T	c.(1453-1455)GAG>TAG	p.E485*	TRIM47_uc002jpv.2_Nonsense_Mutation_p.E247*	NM_033452	NP_258411	Q96LD4	TRI47_HUMAN	tripartite motif-containing 47	485	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			ovary(2)|prostate(1)|lung(1)|breast(1)	5			Epithelial(20;4.23e-06)|all cancers(21;5.24e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			ATCTCCACCTCCCAGTAGTAG	0.647													50	68					5.39261e-20	6.33833e-20	1	0	A	73871028	A	A	73871028	4	1	5	1	0	0	0	0	0	1	0	0	16589	864	30	2	467	2	TRIM47	17	73871028	Nonsense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	6829574	73871028	7324182	410	1546											
FASN	2194	broad.mit.edu	37	chr17	80041269	80041269	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcatccagtaggaccccgtGgaatgtcacgttcttcagga	9	9	11	12	3	3	0	2	0	1	0	4	3	4	3	3	3	0	3	3	3	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:80041269G>A	uc002kdu.2	-	32	5491	c.5374C>T	c.(5374-5376)CAC>TAC	p.H1792Y	FASN_uc002kdv.1_5'Flank	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	1792	Enoyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	AGGACCCCGTGGAATGTCACG	0.652													35	48					0	0	0	0	A	80041269	A	A	80041269	3	1	5	1	0	0	0	0	1	0	0	0	5715	1348	47	4	2209	4	FASN	17	80041269	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	6170241	80041269	1153941	411	1547											
CCDC57	284001	broad.mit.edu	37	chr17	80159756	80159756	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcggtgtgcctgcagcgccCtccactcctcctccttgcga	3	10	10	18	3	0	0	0	0	0	0	4	1	4	0	6	1	5	1	6	1	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr17:80159756C>T	uc002kdz.1	-	3	420	c.65G>A	c.(64-66)AGG>AAG	p.R22K	CCDC57_uc002kdx.1_Missense_Mutation_p.R22K	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	22										ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			CTGCAGCGCCCTCCACTCCTC	0.657													13	34					0	0	0	0	T	80159756	T	T	80159756	3	4	5	1	0	0	0	0	1	0	0	0	2840	681	24	4	2746	4	CCDC57	17	80159756	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	118487	80159756	1035454	412	1548											
NDC80	10403	broad.mit.edu	37	chr18	2610796	2610796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaccacgactgaagaaagacGaaaagtgggaaataacttgc	19	5	10	7	2	0	3	0	1	0	2	0	6	0	4	1	1	3	0	1	1	7	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:2610796G>A	uc002kli.2	+	16	1909	c.1727G>A	c.(1726-1728)CGA>CAA	p.R576Q		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	576	Potential.|Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex.|Interaction with NEK2 and ZWINT.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						GAAGAAAGACGAAAAGTGGGA	0.378													85	132					0	0	0	0	A	2610796	A	A	2610796	3	1	5	1	0	0	0	0	1	0	0	0	10296	1058	37	1	1785	1	NDC80	18	2610796	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08		2610796	75466452	413	1549											
LAMA1	284217	broad.mit.edu	37	chr18	7016587	7016587	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgacactggccttcatcCgtgcagccatctgacacgga	9	8	10	14	2	2	2	1	2	1	0	3	3	3	3	3	2	2	1	3	2	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:7016587C>A	uc002knm.2	-	21	2986	c.2892G>T	c.(2890-2892)ACG>ACT	p.T964T	LAMA1_uc010wzj.1_Silent_p.T440T	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	964	Laminin EGF-like 10.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCCTTCATCCGTGCAGCCAT	0.592													27	19					1.74807e-11	1.93208e-11	1	0	A	7016587	A	A	7016587	2	1	5	1	0	0	0	0	0	0	0	1	8645	639	23	3		3	LAMA1	18	7016587	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4405791	7016587	71060661	414	1550											
TUBB6	84617	broad.mit.edu	37	chr18	12325303	12325303	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccttcagcgtcatgccctCgcccaaggtgtcggacacgg	7	7	11	16	4	2	0	2	0	0	0	4	1	2	1	3	3	2	0	3	3	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:12325303C>T	uc002kqw.2	+	4	560	c.515C>T	c.(514-516)TCG>TTG	p.S172L	TUBB6_uc002kqv.2_Missense_Mutation_p.S100L|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Missense_Mutation_p.S135L|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	172					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		GTCATGCCCTCGCCCAAGGTG	0.617													98	103					0	0	0	0	T	12325303	T	T	12325303	3	4	5	1	0	0	0	0	1	0	0	0	16828	893	31	1	529	1	TUBB6	18	12325303	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	5308716	12325303	65751945	415	1551											
ROCK1	6093	broad.mit.edu	37	chr18	18535194	18535194	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgggttacaggtctaacGtgaaacagtttactaaaatg	13	12	9	7	1	1	1	0	1	1	0	1	1	1	1	1	2	4	2	1	2	6	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:18535194G>C	uc002kte.2	-	30	4466	c.3525C>G	c.(3523-3525)CAC>CAG	p.H1175Q		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1175	PH.|Auto-inhibitory.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					CAGGTCTAACGTGAAACAGTT	0.229													14	23					0	0	0	0	C	18535194	C	C	18535194	3	2	5	1	0	0	0	0	1	0	0	0	13582	1136	40	3	555	3	ROCK1	18	18535194	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	6209891	18535194	59542054	416	1552											
MAPRE2	10982	broad.mit.edu	37	chr18	32681988	32681988	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatggtttaagaaattctatGatgctaactacgatgggaag	15	12	10	4	1	1	2	0	1	1	1	1	4	1	3	0	2	3	2	0	2	7	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:32681988G>C	uc002kyg.2	+	4	655	c.475G>C	c.(475-477)GAT>CAT	p.D159H	MAPRE2_uc010xcb.1_Missense_Mutation_p.D116H|MAPRE2_uc010xcc.1_Missense_Mutation_p.D147H|MAPRE2_uc002kyf.2_Missense_Mutation_p.D159H|MAPRE2_uc002kyh.2_Missense_Mutation_p.D106H|MAPRE2_uc010xcd.1_Missense_Mutation_p.D116H	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	159	CH.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						GAAATTCTATGATGCTAACTA	0.423													44	54					0	0	0	0	C	32681988	C	C	32681988	3	2	5	1	0	0	0	0	1	0	0	0	9348	1290	45	2	583	2	MAPRE2	18	32681988	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	14146794	32681988	45395260	417	1553											
LIPG	9388	broad.mit.edu	37	chr18	47108775	47108775	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgtcttcagttacaagaaCatgggagaaattgagcccac	14	9	9	9	0	2	3	1	1	1	2	2	4	2	3	1	1	3	1	1	1	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:47108775C>T	uc002ldv.2	+	7	1332	c.1080C>T	c.(1078-1080)AAC>AAT	p.N360N	LIPG_uc010xdh.1_Silent_p.N286N	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	360	PLAT.				cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						GTTACAAGAACATGGGAGAAA	0.443													43	89					0	0	0	0	T	47108775	T	T	47108775	2	4	5	1	0	0	0	0	0	0	0	1	8865	477	17	4		4	LIPG	18	47108775	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	14426787	47108775	30968473	418	1554											
DCC	1630	broad.mit.edu	37	chr18	50450086	50450086	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccctcatagatccaggacTgcatagacagctgtattttc	10	12	7	12	0	1	2	1	0	0	2	4	3	3	3	3	1	2	3	3	1	3	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:50450086T>A	uc002lfe.1	+	4	1294	c.707T>A	c.(706-708)CTG>CAG	p.L236Q	DCC_uc010xdr.1_Missense_Mutation_p.L84Q	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	236	Extracellular (Potential).|Ig-like C2-type 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GATCCAGGACTGCATAGACAG	0.363													39	97					0	0	0	0	A	50450086	A	A	50450086	3	1	5	1	0	0	0	0	1	0	0	0	4299	1580	55	5	721	5	DCC	18	50450086	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	3341311	50450086	27627162	419	1555											
DCC	1630	broad.mit.edu	37	chr18	51013172	51013172	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttttcttttgcagctgtcGtgagcgccatcccggtgcca	4	14	10	13	3	1	1	0	1	1	0	3	1	2	1	3	1	4	2	3	1	0	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:51013172G>C	uc002lfe.1	+	26	4329	c.3742G>C	c.(3742-3744)GTG>CTG	p.V1248L	DCC_uc010dpf.1_Missense_Mutation_p.V883L	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1248	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGCAGCTGTCGTGAGCGCCAT	0.488													80	100					0	0	0	0	C	51013172	C	C	51013172	3	2	5	1	0	0	0	0	1	0	0	0	4299	1145	40	3	3844	3	DCC	18	51013172	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	563086	51013172	27064076	420	1556											
PIGN	23556	broad.mit.edu	37	chr18	59821827	59821827	+	Frame_Shift_Del	DEL	C	-	-																															gttttgttgcatcttgagcaCcaaaatcctctcttttagca																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:59821827delC	uc002lii.3	-	7	948	c.500delG	c.(499-501)GGTfs	p.G167fs	PIGN_uc002lij.3_Frame_Shift_Del_p.G167fs	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	167	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				ATCTTGAGCACCAAAATCCTC	0.313													---	---	---								-	59821827	-	-	59821827	7	5	5	1	0	1	0	1	0	0	0	0	11948	507	18	0	2395	0	PIGN	18	59821827	Frame_Shift_Del	DEL	C	TCGA-BA-4078-01A-01D-1434-08	8808655	59821827	18255421	421	1557											
CDH7	1005	broad.mit.edu	37	chr18	63489364	63489364	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatagagaggctaaagacCagtatttgcttgtcattcag	12	12	11	6	0	2	2	2	0	0	2	2	4	2	3	1	2	1	3	1	2	4	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:63489364C>A	uc002ljz.2	+	5	998	c.673C>A	c.(673-675)CAG>AAG	p.Q225K	CDH7_uc002lka.2_Missense_Mutation_p.Q225K|CDH7_uc002lkb.2_Missense_Mutation_p.Q225K	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	225	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GGCTAAAGACCAGTATTTGCT	0.403													43	60					1.02591e-13	1.14596e-13	1	0	A	63489364	A	A	63489364	3	1	5	1	0	0	0	0	1	0	0	0	3130	595	21	4	687	4	CDH7	18	63489364	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3667537	63489364	14587884	422	1558											
ZNF407	55628	broad.mit.edu	37	chr18	72344239	72344239	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctgagcgaaatattctcGtgttgggtaatagctttcgt	9	14	11	7	3	1	1	0	1	1	0	3	3	1	1	1	1	2	3	1	1	4	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr18:72344239G>T	uc002llw.2	+	1	1321	c.1264G>T	c.(1264-1266)GTG>TTG	p.V422L	ZNF407_uc010xfc.1_Missense_Mutation_p.V422L|ZNF407_uc010dqu.1_Missense_Mutation_p.V422L|ZNF407_uc002llu.2_Missense_Mutation_p.V421L	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AAATATTCTCGTGTTGGGTAA	0.433													51	63					2.74695e-27	3.5103e-27	1	0	T	72344239	T	T	72344239	3	4	5	1	0	0	0	0	1	0	0	0	17954	1145	40	3	1266	3	ZNF407	18	72344239	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	8854875	72344239	5733009	423	1559											
PIP5K1C	23396	broad.mit.edu	37	chr19	3664871	3664871	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacctcgatggcccaacttCttcccatggccagggcccgg	7	7	10	17	2	1	0	0	0	1	0	3	1	2	0	5	4	1	0	5	4	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:3664871C>T	uc002lyj.1	-	3	225	c.168G>A	c.(166-168)AAG>AAA	p.K56K	PIP5K1C_uc010xhq.1_Silent_p.K56K|PIP5K1C_uc010xhr.1_Silent_p.K56K	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	56					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		GGCCCAACTTCTTCCCATGGC	0.632													90	121					0	0	0	0	T	3664871	T	T	3664871	2	4	5	1	0	0	0	0	0	0	0	1	11996	912	32	2		2	PIP5K1C	19	3664871	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08		3664871	55464112	424	1560											
ANKRD24	170961	broad.mit.edu	37	chr19	4200161	4200161	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaatgtcatgagcgcggaCggggcaggtactgccagctg	9	6	16	10	3	1	1	1	1	0	0	1	2	1	2	1	4	5	4	1	4	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:4200161C>T	uc010dtt.1	+	5	612	c.336C>T	c.(334-336)GAC>GAT	p.D112D	ANKRD24_uc002lzs.2_Silent_p.D83D|ANKRD24_uc002lzt.2_Silent_p.D84D	NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	112											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		TGAGCGCGGACGGGGCAGGTA	0.652													3	17					0	0	0	0	T	4200161	T	T	4200161	2	4	5	1	0	0	0	0	0	0	0	1	653	535	19	1		1	ANKRD24	19	4200161	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	535290	4200161	54928822	425	1561											
KDM4B	23030	broad.mit.edu	37	chr19	5134010	5134010	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggccgagaggaagttcaacGcagcggctgcgcgcacggag	10	3	17	11	6	1	1	1	0	0	1	1	4	1	3	1	4	3	4	1	4	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:5134010G>T	uc002mbq.3	+	14	2249	c.2023G>T	c.(2023-2025)GCA>TCA	p.A675S	KDM4B_uc010xim.1_Missense_Mutation_p.A709S|KDM4B_uc002mbr.3_Missense_Mutation_p.A433S	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	675					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						GAAGTTCAACGCAGCGGCTGC	0.667													93	139					7.0407e-44	1.01502e-43	1	0	T	5134010	T	T	5134010	3	4	5	1	0	0	0	0	1	0	0	0	8168	1087	38	3	2069	3	KDM4B	19	5134010	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	933849	5134010	53994973	426	1562											
TMEM146	257062	broad.mit.edu	37	chr19	5727297	5727297	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggaccgcctgtattttcatCctacaacaacacgcttgatt	11	12	6	12	2	1	1	1	1	0	0	2	2	2	2	3	1	3	2	3	1	4	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:5727297C>A	uc002mda.2	+	3	206	c.145C>A	c.(145-147)CCT>ACT	p.P49T	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	49	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTATTTTCATCCTACAACAAC	0.284													61	76					9.04393e-38	1.25224e-37	1	0	A	5727297	A	A	5727297	3	1	5	1	0	0	0	0	1	0	0	0	16126	855	30	2	155	2	TMEM146	19	5727297	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	593287	5727297	53401686	427	1563											
TNFSF14	8740	broad.mit.edu	37	chr19	6664993	6664993	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcacgcagtcgaaccaggcGttcatccagcacacggacga	12	5	10	14	5	2	0	2	0	0	0	4	3	3	1	2	2	2	3	2	2	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:6664993G>A	uc002mfk.1	-	5	1049	c.667C>T	c.(667-669)CGC>TGC	p.R223C	TNFSF14_uc002mfj.1_Missense_Mutation_p.R187C	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	223	Extracellular (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						CGAACCAGGCGTTCATCCAGC	0.612													109	155					0	0	0	0	A	6664993	A	A	6664993	3	1	5	1	0	0	0	0	1	0	0	0	16373	1145	40	1	59	1	TNFSF14	19	6664993	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	937696	6664993	52463990	428	1564											
MUC16	94025	broad.mit.edu	37	chr19	9007503	9007503	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttacttgtggggctggggacGggggatggagtccctgaggt	5	10	20	6	1	0	1	0	1	0	0	1	4	1	4	1	8	1	1	1	8	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:9007503G>T	uc002mkp.2	-	43	39669	c.39465C>A	c.(39463-39465)CCC>CCA	p.P13155P	MUC16_uc010dwi.2_5'Flank|MUC16_uc010dwj.2_5'Flank|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCTGGGGACGGGGGATGGAG	0.463													13	32					3.32936e-07	3.5252e-07	1	0	T	9007503	T	T	9007503	2	4	5	1	0	0	0	0	0	0	0	1	10026	1103	39	3		3	MUC16	19	9007503	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2342510	9007503	50121480	429	1565											
MUC16	94025	broad.mit.edu	37	chr19	9026207	9026207	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaccagaccctgcaggacaCtctccatggtgttgaacttc	10	10	8	13	0	1	2	0	1	1	1	3	3	1	3	3	2	3	2	3	2	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:9026207C>A	uc002mkp.2	-	14	36983	c.36779G>T	c.(36778-36780)AGT>ATT	p.S12260I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12262	SEA 2.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGCAGGACACTCTCCATGGT	0.552													143	192					6.37441e-58	9.67682e-58	1	0	A	9026207	A	A	9026207	3	1	5	1	0	0	0	0	1	0	0	0	10026	565	20	4	7028	4	MUC16	19	9026207	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	18704	9026207	50102776	430	1566											
MUC16	94025	broad.mit.edu	37	chr19	9072003	9072003	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccatttgagttgtggctttgGgtgtctctgagtcagccagt	5	15	13	8	0	2	2	1	2	1	0	3	2	2	2	2	2	1	2	2	2	0	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:9072003G>T	uc002mkp.2	-	3	15647	c.15443C>A	c.(15442-15444)CCC>CAC	p.P5148H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5150	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTGGCTTTGGGTGTCTCTGA	0.458													132	167					5.80972e-51	8.67328e-51	1	0	T	9072003	T	T	9072003	3	4	5	1	0	0	0	0	1	0	0	0	10026	1232	43	4	28408	4	MUC16	19	9072003	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	45796	9072003	50056980	431	1567											
ILF3	3609	broad.mit.edu	37	chr19	10794209	10794209	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagagggggaccgaaattTgctgctaaggtgagcagtgg	10	8	17	6	1	1	2	1	1	0	1	1	4	1	3	1	4	3	3	1	4	2	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:10794209T>C	uc002mpn.2	+	15	2159	c.1842T>C	c.(1840-1842)TTT>TTC	p.F614F	ILF3_uc002mpm.2_Silent_p.F618F|ILF3_uc002mpl.2_Silent_p.F614F|ILF3_uc002mpk.2_Silent_p.F614F|ILF3_uc010xli.1_Silent_p.F212F|ILF3_uc002mpo.2_Silent_p.F618F|ILF3_uc002mpp.2_Silent_p.F439F|ILF3_uc002mpq.2_5'Flank	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	614	Interaction with PRMT1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GACCGAAATTTGCTGCTAAGG	0.537													75	118					0	0	0	0	C	10794209	C	C	10794209	2	2	5	1	0	0	0	0	0	0	0	1	7751	1809	63	5		5	ILF3	19	10794209	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	1722206	10794209	48334774	432	1568											
RGL3	57139	broad.mit.edu	37	chr19	11510943	11510943	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctggggcaggaggcagcTggtggctcaatgacccggga	8	5	19	9	1	1	1	1	1	0	0	1	4	1	3	1	7	2	5	1	7	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:11510943T>C	uc002mrp.2	-	14	1579	c.1515A>G	c.(1513-1515)CCA>CCG	p.P505P	RGL3_uc002mrn.2_Silent_p.P269P|RGL3_uc002mrm.2_Silent_p.P269P|RGL3_uc002mro.2_Silent_p.P505P	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	505	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						AGGAGGCAGCTGGTGGCTCAA	0.612													44	83					0	0	0	0	C	11510943	C	C	11510943	2	2	5	1	0	0	0	0	0	0	0	1	13343	1567	55	5		5	RGL3	19	11510943	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	716734	11510943	47618040	433	1569											
ZNF442	79973	broad.mit.edu	37	chr19	12461204	12461204	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgaggtccatctccagtgtGcattatcatatgacttcgaa	10	13	9	9	1	2	2	1	2	1	0	5	3	3	2	2	1	1	1	2	1	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:12461204G>A	uc002mtr.1	-	6	1806	c.1195C>T	c.(1195-1197)CAC>TAC	p.H399Y	ZNF442_uc010xmk.1_Missense_Mutation_p.H330Y	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	399	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						TCTCCAGTGTGCATTATCATA	0.428													168	241					0	0	0	0	A	12461204	A	A	12461204	3	1	5	1	0	0	0	0	1	0	0	0	17982	1319	46	4	692	4	ZNF442	19	12461204	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	950261	12461204	46667779	434	1570											
WIZ	58525	broad.mit.edu	37	chr19	15558935	15558935	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agagatgccacctctgccatCcagaatgtctcgggggccct	8	8	11	14	1	2	2	0	0	2	2	4	3	3	2	5	2	2	0	5	2	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:15558935C>A	uc002nbb.3	-	2	398	c.184G>T	c.(184-186)GAT>TAT	p.D62Y	MIR1470_hsa-mir-1470|MI0007075_5'Flank	NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						nucleus	zinc ion binding				0						CCTCTGCCATCCAGAATGTCT	0.627													88	135					7.22319e-40	1.01803e-39	1	0	A	15558935	A	A	15558935	3	1	5	1	0	0	0	0	1	0	0	0	17443	855	30	2	2228	2	WIZ	19	15558935	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	3097731	15558935	43570048	435	1571											
EPS15L1	58513	broad.mit.edu	37	chr19	16532206	16532206	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctggccactcacgtagcCatccaggtccaggtcggtct	6	9	10	16	2	2	0	1	0	1	0	6	0	5	0	5	4	1	1	5	4	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:16532206C>A	uc002ndz.1	-	10	880	c.874G>T	c.(874-876)GGC>TGC	p.G292C	EPS15L1_uc002ndx.2_Missense_Mutation_p.G292C|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.G182C|EPS15L1_uc010xpf.1_Missense_Mutation_p.G195C|EPS15L1_uc002nea.1_Missense_Mutation_p.G292C|EPS15L1_uc010eah.1_Missense_Mutation_p.G292C|EPS15L1_uc002neb.1_Missense_Mutation_p.G138C|EPS15L1_uc002nec.1_Missense_Mutation_p.G292C	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	292	EH 3.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						CTCACGTAGCCATCCAGGTCC	0.537													57	58					3.16986e-14	3.54709e-14	1	0	A	16532206	A	A	16532206	3	1	5	1	0	0	0	0	1	0	0	0	5217	594	21	4	1776	4	EPS15L1	19	16532206	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	973271	16532206	42596777	436	1572											
OCEL1	79629	broad.mit.edu	37	chr19	17337113	17337113	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatccaggctcggagctccaGacgctgggacaggtgacccg	8	5	15	13	3	0	2	0	1	0	1	3	5	2	4	3	4	1	3	3	4	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:17337113G>C	uc002nfp.2	+	1	59	c.57G>C	c.(55-57)CAG>CAC	p.Q19H		NM_024578	NP_078854	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	19										central_nervous_system(1)	1						CGGAGCTCCAGACGCTGGGAC	0.692													3	12					0	0	0	0	C	17337113	C	C	17337113	3	2	5	1	0	0	0	0	1	0	0	0	10870	933	33	2	59	2	OCEL1	19	17337113	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	804907	17337113	41791870	437	1573											
FCHO1	23149	broad.mit.edu	37	chr19	17886888	17886888	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcaagcctgccccggcccGggctccagcctgcagccccg	5	4	11	21	3	1	0	1	0	0	0	2	0	2	0	8	2	5	2	8	2	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:17886888G>T	uc010ebb.2	+	15	1289	c.1100G>T	c.(1099-1101)CGG>CTG	p.R367L	FCHO1_uc002nhg.3_Missense_Mutation_p.R367L|FCHO1_uc002nhh.2_Missense_Mutation_p.R367L|FCHO1_uc010xpw.1_Missense_Mutation_p.R317L|FCHO1_uc002nhi.2_5'Flank|FCHO1_uc002nhj.2_5'Flank	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	367										breast(1)	1						GCCCCGGCCCGGGCTCCAGCC	0.697													56	63					8.77104e-35	1.18834e-34	1	0	T	17886888	T	T	17886888	3	4	5	1	0	0	0	0	1	0	0	0	5819	1116	39	3	1150	3	FCHO1	19	17886888	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	549775	17886888	41242095	438	1574											
ZNF253	56242	broad.mit.edu	37	chr19	20002455	20002455	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggaggttataatggacttaaCcaatgtttgacaactaccca	14	11	8	8	0	0	1	0	1	0	0	0	3	0	3	2	3	3	2	2	3	6	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:20002455C>G	uc002noj.2	+	4	491	c.399C>G	c.(397-399)AAC>AAG	p.N133K	ZNF253_uc002nok.2_Missense_Mutation_p.N57K|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	133					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGGACTTAACCAATGTTTGA	0.323													28	66					0	0	0	0	G	20002455	G	G	20002455	3	3	5	1	0	0	0	0	1	0	0	0	17864	506	18	4	413	4	ZNF253	19	20002455	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2115567	20002455	39126528	439	1575											
ZNF493	284443	broad.mit.edu	37	chr19	21607279	21607279	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctacaaatgtgaagaatgTggcaaagcttttaaccgatc	14	10	8	9	1	0	2	0	1	0	1	1	3	0	2	2	1	3	2	2	1	6	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:21607279T>C	uc002npx.2	+	2	1714	c.1434T>C	c.(1432-1434)TGT>TGC	p.C478C	ZNF493_uc002npw.2_Silent_p.C606C|ZNF493_uc002npy.2_Silent_p.C478C	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	478	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTGAAGAATGTGGCAAAGCTT	0.333													25	39					0	0	0	0	C	21607279	C	C	21607279	2	2	5	1	0	0	0	0	0	0	0	1	18011	1702	59	5		5	ZNF493	19	21607279	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	1604824	21607279	37521704	440	1576											
DPY19L3	147991	broad.mit.edu	37	chr19	32973120	32973120	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccagaacaaaaccttccacGtttacaagctgtccagaaac	15	8	5	13	1	0	2	0	0	0	2	3	2	3	2	4	0	5	2	4	0	6	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:32973120G>T	uc002ntg.2	+	19	2301	c.2125G>T	c.(2125-2127)GTT>TTT	p.V709F	DPY19L3_uc002nth.1_Missense_Mutation_p.V709F|DPY19L3_uc002nti.1_RNA|DPY19L3_uc002ntj.1_Missense_Mutation_p.V131F	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	709						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					AACCTTCCACGTTTACAAGCT	0.458													102	157					1.33972e-64	2.04859e-64	1	0	T	32973120	T	T	32973120	3	4	5	1	0	0	0	0	1	0	0	0	4764	1145	40	3	2195	3	DPY19L3	19	32973120	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	11365841	32973120	26155863	441	1577											
RHPN2	85415	broad.mit.edu	37	chr19	33482784	33482784	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacgggggcgttccctctcAaggtgaaccccaagtcccct	8	7	11	15	2	1	1	1	1	1	0	4	2	3	1	5	3	2	1	5	3	4	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:33482784A>T	uc002nuf.2	-	13	1655	c.1589T>A	c.(1588-1590)TTG>TAG	p.L530*	RHPN2_uc010xro.1_Nonsense_Mutation_p.L379*|RHPN2_uc002nue.2_Nonsense_Mutation_p.L260*	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	530	PDZ.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					GTTCCCTCTCAAGGTGAACCC	0.537													46	90					0	0	0	0	T	33482784	T	T	33482784	4	4	5	1	0	0	0	0	0	1	0	0	13416	131	5	5	483	5	RHPN2	19	33482784	Nonsense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	509664	33482784	25646199	442	1578											
LRP3	4037	broad.mit.edu	37	chr19	33696633	33696633	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcctgggcgagcgcggggaCcgcctgctgcagacgctgtc	4	5	18	14	5	0	1	0	0	0	1	1	3	0	2	3	4	3	3	3	4	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:33696633C>T	uc010edh.2	+	5	1050	c.957C>T	c.(955-957)GAC>GAT	p.D319D	LRP3_uc010xrp.1_Silent_p.D193D|LRP3_uc002nuk.3_Silent_p.D193D	NM_002333	NP_002324	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein	319	Extracellular (Potential).|CUB 2.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			pancreas(2)|ovary(1)	3	Esophageal squamous(110;0.137)					AGCGCGGGGACCGCCTGCTGC	0.711													6	11					0	0	0	0	T	33696633	T	T	33696633	2	4	5	1	0	0	0	0	0	0	0	1	9008	506	18	4		4	LRP3	19	33696633	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	213849	33696633	25432350	443	1579											
CD22	933	broad.mit.edu	37	chr19	35828817	35828817	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaagcagaatacattcaCgctaaacctgcgcgaagtga	16	6	10	9	3	1	3	1	1	0	2	1	5	1	3	1	0	4	2	1	0	7	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:35828817C>T	uc010edt.2	+	5	955	c.878C>T	c.(877-879)ACG>ATG	p.T293M	CD22_uc010xst.1_Missense_Mutation_p.T121M|CD22_uc010edu.2_Missense_Mutation_p.T293M|CD22_uc010edv.2_Missense_Mutation_p.T293M|CD22_uc002nzb.3_Intron|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	293	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion		protein binding|sugar binding	p.T293T(1)		ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AATACATTCACGCTAAACCTG	0.562													32	48					0	0	0	0	T	35828817	T	T	35828817	3	4	5	1	0	0	0	0	1	0	0	0	3000	536	19	1	892	1	CD22	19	35828817	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	2132184	35828817	23300166	444	1580											
NPHS1	4868	broad.mit.edu	37	chr19	36341873	36341873	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacactcactcaggagaatGgtgatgtcaggtgctggctt	9	10	12	10	0	3	2	3	1	0	1	3	3	3	2	1	4	1	2	1	4	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:36341873G>A	uc002oby.2	-	4	516	c.516C>T	c.(514-516)ACC>ACT	p.T172T		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	172	Ig-like C2-type 2.|Extracellular (Potential).		Missing (in NPHS1).		cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCAGGAGAATGGTGATGTCAG	0.602													21	28					0	0	0	0	A	36341873	A	A	36341873	2	1	5	1	0	0	0	0	0	0	0	1	10636	1335	47	4		4	NPHS1	19	36341873	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	513056	36341873	22787110	445	1581											
ZNF566	84924	broad.mit.edu	37	chr19	36964331	36964331	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cactcctcctgagagaagtcTacggacacatcactgaacat	13	8	7	13	1	2	3	1	2	1	1	4	5	4	4	2	1	2	0	2	1	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:36964331T>C	uc002oea.3	-	3	121	c.39A>G	c.(37-39)GTA>GTG	p.V13V	ZNF566_uc010xte.1_Silent_p.V13V|ZNF566_uc010xtf.1_Silent_p.V13V|ZNF566_uc002oeb.3_Silent_p.V13V|ZNF566_uc002oec.3_Intron|ZNF566_uc010xtg.1_Intron	NM_032838	NP_116227	Q969W8	ZN566_HUMAN	zinc finger protein 566 isoform 1	13	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					GAGAGAAGTCTACGGACACAT	0.388													84	133					0	0	0	0	C	36964331	C	C	36964331	2	2	5	1	0	0	0	0	0	0	0	1	18064	1509	53	5		5	ZNF566	19	36964331	Silent	SNP	T	TCGA-BA-4078-01A-01D-1434-08	622458	36964331	22164652	446	1582											
RYR1	6261	broad.mit.edu	37	chr19	38934789	38934789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cattccatccccacccatagGagaggcttgctggtggacca	9	8	10	14	0	0	1	0	0	0	1	2	3	2	2	5	4	1	2	5	4	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:38934789G>A	uc002oit.2	+	6	555	c.425G>A	c.(424-426)GGA>GAA	p.G142E	RYR1_uc002oiu.2_Missense_Mutation_p.G142E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	142	Cytoplasmic.|MIR 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCACCCATAGGAGAGGCTTGC	0.612													20	34					0	0	0	0	A	38934789	A	A	38934789	3	1	5	1	0	0	0	0	1	0	0	0	13833	1188	41	2	447	2	RYR1	19	38934789	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1970458	38934789	20194194	447	1583											
CYP2B6	1555	broad.mit.edu	37	chr19	41515933	41515933	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacagtgaattcagccaccAgaacctcaacctcaacacgc	15	5	5	16	1	3	2	3	1	0	1	3	2	3	2	4	0	4	0	4	0	4	1	rs146617126	byFrequency	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:41515933A>T	uc002opr.1	+	6	864	c.857A>T	c.(856-858)CAG>CTG	p.Q286L	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	286					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	TTCAGCCACCAGAACCTCAAC	0.562													43	62					0	0	0	0	T	41515933	T	T	41515933	3	4	5	1	0	0	0	0	1	0	0	0	4181	188	7	5	879	5	CYP2B6	19	41515933	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	2581144	41515933	17613050	448	1584											
DMRTC2	63946	broad.mit.edu	37	chr19	42352590	42352590	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctggcaccgacacccccCgggaaggtaaggagaggctg	9	4	15	13	2	0	1	0	0	0	1	0	4	0	2	4	5	1	4	4	5	2	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:42352590C>A	uc002ors.2	+	4	524	c.441C>A	c.(439-441)CCC>CCA	p.P147P	DMRTC2_uc002orr.1_Missense_Mutation_p.P11Q|DMRTC2_uc010xwe.1_Silent_p.P147P	NM_001040283	NP_001035373	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	147	Pro-rich.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						CGACACCCCCCGGGAAGGTAA	0.552													6	22					8.12818e-05	8.38094e-05	1	0	A	42352590	A	A	42352590	2	1	5	1	0	0	0	0	0	0	0	1	4613	639	23	3		3	DMRTC2	19	42352590	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	836657	42352590	16776393	449	1585											
ZNF578	147660	broad.mit.edu	37	chr19	53013842	53013843	+	Missense_Mutation	DNP	AT	TG	TG																															tagatatctcttccaaacgcAtgatgaaggaggtcttgtca																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:53013842_53013843AT>TG	uc002pzp.3	+	6	452_453	c.208_209AT>TG	c.(208-210)ATG>TGG	p.M70W		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	Error:Variant_position_missing_in_Q96N58_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		TTCCAAACGCATGATGAAGGAG	0.371													111	214					0	0	0	0	TG	53013843	TG	TG	53013842	3	4	5	1	0	0	0	0	1	0	0	0	18077	217	8	5	218	5	ZNF578	19	53013842	Missense_Mutation	DNP	AT	TCGA-BA-4078-01A-01D-1434-08	10661252	53013842	6115141	450	1586											
ZNF320	162967	broad.mit.edu	37	chr19	53384177	53384177	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgaagtttttgatgacatGcgaggtacgcttttgtacta	10	16	10	5	2	0	3	0	3	0	0	0	4	0	3	0	1	3	4	0	1	5	8			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:53384177G>A	uc002qag.2	-	4	1393	c.1202C>T	c.(1201-1203)GCA>GTA	p.A401V	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.A347V|ZNF320_uc002qai.2_Missense_Mutation_p.A401V	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	401	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TTGATGACATGCGAGGTACGC	0.388													61	114					0	0	0	0	A	53384177	A	A	53384177	3	1	5	1	0	0	0	0	1	0	0	0	17906	1319	46	4	331	4	ZNF320	19	53384177	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	370335	53384177	5744806	451	1587											
ZNF761	388561	broad.mit.edu	37	chr19	53959133	53959133	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcccttacatgccatcgtAgacgtcatactggagagcaa	12	9	8	12	2	1	2	1	0	0	2	3	3	2	2	2	1	4	2	2	1	4	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:53959133A>G	uc010eqp.2	+	7	1830	c.1372A>G	c.(1372-1374)AGA>GGA	p.R458G	ZNF761_uc010ydy.1_Missense_Mutation_p.R404G|ZNF761_uc002qbt.1_Missense_Mutation_p.R404G	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	458	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		ATGCCATCGTAGACGTCATAC	0.388													76	104					0	0	0	0	G	53959133	G	G	53959133	3	3	5	1	0	0	0	0	1	0	0	0	18203	412	15	5	1383	5	ZNF761	19	53959133	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	574956	53959133	5169850	452	1588											
NLRP12	91662	broad.mit.edu	37	chr19	54314439	54314439	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccttcaccagcaggagccgGgtgtaccggtggctgaggtt	6	9	15	11	2	1	1	1	1	0	0	2	2	2	2	4	5	3	4	4	5	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:54314439G>T	uc002qch.3	-	3	694	c.474C>A	c.(472-474)ACC>ACA	p.T158T	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.T158T|NLRP12_uc002qcj.3_Silent_p.T158T|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.T158T	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	158					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GCAGGAGCCGGGTGTACCGGT	0.617													93	128					8.64784e-51	1.28798e-50	1	0	T	54314439	T	T	54314439	2	4	5	1	0	0	0	0	0	0	0	1	10528	1219	43	4		4	NLRP12	19	54314439	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	355306	54314439	4814544	453	1589											
NLRP2	55655	broad.mit.edu	37	chr19	55494535	55494535	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggacggagacatcctccGccaggacagagtctccaaag	11	5	11	14	2	1	2	0	0	1	2	4	5	3	4	5	3	0	0	5	3	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:55494535G>C	uc002qij.2	+	6	1555	c.1469G>C	c.(1468-1470)CGC>CCC	p.R490P	NLRP2_uc010yfp.1_Missense_Mutation_p.R467P|NLRP2_uc010esn.2_Missense_Mutation_p.R466P|NLRP2_uc010eso.2_Missense_Mutation_p.R487P|NLRP2_uc010esp.2_Missense_Mutation_p.R468P	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	490	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GACATCCTCCGCCAGGACAGA	0.602													49	77					0	0	0	0	C	55494535	C	C	55494535	3	2	5	1	0	0	0	0	1	0	0	0	10531	1087	38	3	1487	3	NLRP2	19	55494535	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1180096	55494535	3634448	454	1590											
NLRP5	126206	broad.mit.edu	37	chr19	56539566	56539566	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggaggtcctgctgggctgtcCcgttcccctgggggtgaagc	3	9	17	12	1	0	1	0	1	0	0	3	2	3	2	4	5	2	3	4	5	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:56539566C>A	uc002qmj.2	+	7	1967	c.1967C>A	c.(1966-1968)CCC>CAC	p.P656H	NLRP5_uc002qmi.2_Missense_Mutation_p.P637H	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	656						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTGGGCTGTCCCGTTCCCCTG	0.597													77	113					5.21738e-30	6.79122e-30	1	0	A	56539566	A	A	56539566	3	1	5	1	0	0	0	0	1	0	0	0	10534	623	22	4	1993	4	NLRP5	19	56539566	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1045031	56539566	2589417	455	1591											
ZNF582	147948	broad.mit.edu	37	chr19	56895725	56895725	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaattctctgatgtcgtataAgagttgagccttgattaaaa	13	14	9	5	1	1	4	0	3	1	1	3	5	1	4	1	0	1	2	1	0	5	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:56895725A>G	uc002qmz.1	-	5	1220	c.1061T>C	c.(1060-1062)CTT>CCT	p.L354P	ZNF582_uc002qmy.2_Missense_Mutation_p.L385P	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	354	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		ATGTCGTATAAGAGTTGAGCC	0.418													105	135					0	0	0	0	G	56895725	G	G	56895725	3	3	5	1	0	0	0	0	1	0	0	0	18081	72	3	5	496	5	ZNF582	19	56895725	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	356159	56895725	2233258	456	1592											
ZNF835	90485	broad.mit.edu	37	chr19	57176253	57176253	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atttccacggcttcttggggCctccacctctctcccgctgg	3	12	9	17	2	2	0	0	0	2	0	6	0	5	0	5	4	0	2	5	4	0	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:57176253C>A	uc010ygo.1	-	2	380	c.380G>T	c.(379-381)GGC>GTC	p.G127V	ZNF835_uc010ygn.1_Missense_Mutation_p.G105V	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CTTCTTGGGGCCTCCACCTCT	0.632													26	43					7.01153e-11	7.66887e-11	1	0	A	57176253	A	A	57176253	3	1	5	1	0	0	0	0	1	0	0	0	18253	739	26	4	1301	4	ZNF835	19	57176253	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	280528	57176253	1952730	457	1593											
ZNF548	147694	broad.mit.edu	37	chr19	57910559	57910559	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catttgttagacatcagagaGttcacaccggagaaaggccg	13	8	11	9	2	2	3	2	0	0	3	2	5	2	3	2	2	0	2	2	2	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:57910559G>T	uc002qom.2	+	3	1154	c.904G>T	c.(904-906)GTT>TTT	p.V302F	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.V305F	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	302	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACATCAGAGAGTTCACACCGG	0.458													38	65					4.62619e-21	5.49906e-21	1	0	T	57910559	T	T	57910559	3	4	5	1	0	0	0	0	1	0	0	0	18047	1029	36	4	954	4	ZNF548	19	57910559	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	734306	57910559	1218424	458	1594											
ZSCAN1	284312	broad.mit.edu	37	chr19	58549383	58549383	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctcgcgctgggccagctctGgacgctgtgccgccagtggc	3	7	15	16	4	1	0	0	0	1	0	2	1	1	1	4	3	2	3	4	3	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:58549383G>C	uc002qrc.1	+	3	426	c.179G>C	c.(178-180)TGG>TCG	p.W60S	ZSCAN1_uc002qra.1_Missense_Mutation_p.W60S|ZSCAN1_uc002qrb.1_Missense_Mutation_p.W60S	NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	60	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGCCAGCTCTGGACGCTGTGC	0.711													8	7					0	0	0	0	C	58549383	C	C	58549383	3	2	5	1	0	0	0	0	1	0	0	0	18293	1357	47	4	181	4	ZSCAN1	19	58549383	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	638824	58549383	579600	459	1595											
ZNF497	162968	broad.mit.edu	37	chr19	58868799	58868799	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagctccctgccggggcctCcctgttcgtccgccgccccc	1	7	10	23	4	0	0	0	0	0	0	4	0	3	0	9	2	2	2	9	2	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr19:58868799C>A	uc002qsh.1	-	3	392	c.203G>T	c.(202-204)GGA>GTA	p.G68V	A1BG_uc002qsf.1_Intron|ZNF497_uc002qsi.1_Missense_Mutation_p.G68V|uc002qsj.1_Missense_Mutation_p.S57Y|uc002qsk.1_5'Flank	NM_198458	NP_940860	Q6ZNH5	ZN497_HUMAN	zinc finger protein 497	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0278)		GCCGGGGCCTCCCTGTTCGTC	0.746													6	11					0.000442599	0.000454133	1	0	A	58868799	A	A	58868799	3	1	5	1	0	0	0	0	1	0	0	0	18013	855	30	2	1297	2	ZNF497	19	58868799	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	319416	58868799	260184	460	1596											
ANGPT4	51378	broad.mit.edu	37	chr20	870932	870932	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggtgcccagctctagcatgGgggccgtctgattctgggcc	4	10	15	12	1	3	1	0	1	3	0	3	1	3	1	3	4	3	2	3	4	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:870932G>C	uc002wei.2	-	2	492	c.389C>G	c.(388-390)CCC>CGC	p.P130R	ANGPT4_uc010zpn.1_Missense_Mutation_p.P124R	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	130	Potential.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						CTCTAGCATGGGGGCCGTCTG	0.607													67	125					0	0	0	0	C	870932	C	C	870932	3	2	5	1	0	0	0	0	1	0	0	0	612	1232	43	4	1154	4	ANGPT4	20	870932	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08		870932	62154588	461	1597											
KIF16B	55614	broad.mit.edu	37	chr20	16486697	16486697	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgacgttccccagagtcaCgagggacttgttaatatttc	11	12	9	9	2	1	2	1	1	0	1	3	4	2	3	2	1	0	2	2	1	3	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:16486697C>A	uc002wpg.1	-	8	996	c.838G>T	c.(838-840)GTG>TTG	p.V280L	KIF16B_uc010gch.1_Missense_Mutation_p.V280L|KIF16B_uc010gci.1_Missense_Mutation_p.V280L|KIF16B_uc010gcj.1_Missense_Mutation_p.V280L	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	280	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CCCAGAGTCACGAGGGACTTG	0.512													80	377					9.59377e-39	1.34612e-38	1	0	A	16486697	A	A	16486697	3	1	5	1	0	0	0	0	1	0	0	0	8317	536	19	3	3191	3	KIF16B	20	16486697	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	15615765	16486697	46538823	462	1598											
C20orf26	26074	broad.mit.edu	37	chr20	20177362	20177362	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctttctgaaggagatcctgcGtttaggctttaaatcctgtc	8	15	9	9	1	1	2	0	1	1	1	4	3	3	2	2	2	1	2	2	2	4	5	rs115927004	by1000genomes	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:20177362G>T	uc002wru.2	+	16	1815	c.1739G>T	c.(1738-1740)CGT>CTT	p.R580L	C20orf26_uc010zse.1_Missense_Mutation_p.R560L	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	580										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GAGATCCTGCGTTTAGGCTTT	0.483													120	187					5.01229e-73	7.68307e-73	1	0	T	20177362	T	T	20177362	3	4	5	1	0	0	0	0	1	0	0	0	2116	1145	40	3	1829	3	C20orf26	20	20177362	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	3690665	20177362	42848158	463	1599											
NKX2-4	644524	broad.mit.edu	37	chr20	21376612	21376612	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctgtactccccggcggcCgcgtccagggccgccaggcc	3	4	14	20	6	0	0	0	0	0	0	2	0	2	0	8	4	1	2	8	4	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:21376612C>T	uc010gcz.2	-	2	1012	c.1002G>A	c.(1000-1002)GCG>GCA	p.A334A		NM_033176	NP_149416	Q9H2Z4	NKX24_HUMAN	NK2 homeobox 4	334					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ccccggcggccgcgtccaggg	0.577													17	11					0	0	0	0	T	21376612	T	T	21376612	2	4	5	1	0	0	0	0	0	0	0	1	10506	639	23	1		1	NKX2-4	20	21376612	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1199250	21376612	41648908	464	1600											
PAX1	5075	broad.mit.edu	37	chr20	21687579	21687579	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccagtcccgtgtcgcccacgGgcgccaagatgggcagccac	7	4	13	17	4	0	1	0	0	0	1	2	1	1	1	5	2	1	1	5	2	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:21687579G>T	uc002wsj.2	+	2	844	c.790G>T	c.(790-792)GGC>TGC	p.G264C	PAX1_uc010zsl.1_Missense_Mutation_p.G264C|PAX1_uc010zsm.1_Missense_Mutation_p.G240C	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	264					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						GTCGCCCACGGGCGCCAAGAT	0.697													47	43					1.65492e-34	2.23254e-34	1	0	T	21687579	T	T	21687579	3	4	5	1	0	0	0	0	1	0	0	0	11532	1232	43	4	796	4	PAX1	20	21687579	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	310967	21687579	41337941	465	1601											
SSTR4	6754	broad.mit.edu	37	chr20	23016732	23016732	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcaacctgcagtggccacaCccggcctggtcggcagtctt	6	8	12	15	2	1	0	0	0	1	0	2	0	1	0	4	4	3	3	4	4	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:23016732C>A	uc002wsr.2	+	1	676	c.612C>A	c.(610-612)CAC>CAA	p.H204Q		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	204	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					AGTGGCCACACCCGGCCTGGT	0.657													37	107					1.00953e-15	1.14389e-15	1	0	A	23016732	A	A	23016732	3	1	5	1	0	0	0	0	1	0	0	0	15266	506	18	4	614	4	SSTR4	20	23016732	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1329153	23016732	40008788	466	1602											
GGTLC1	92086	broad.mit.edu	37	chr20	23966370	23966370	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgcagccggggctcctcCacggcccacttcacgtcata	6	9	10	16	3	2	0	2	0	0	0	4	0	4	0	4	3	2	2	4	3	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:23966370C>T	uc002wts.2	-	5	598	c.465G>A	c.(463-465)GTG>GTA	p.V155V	GGTLC1_uc002wtu.2_Silent_p.V155V	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	155							gamma-glutamyltransferase activity			ovary(1)	1						GGGGCTCCTCCACGGCCCACT	0.607													161	125					0	0	0	0	T	23966370	T	T	23966370	2	4	5	1	0	0	0	0	0	0	0	1	6402	581	21	4		4	GGTLC1	20	23966370	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	949638	23966370	39059150	467	1603											
CEP250	11190	broad.mit.edu	37	chr20	34092279	34092279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tacaagaaggtgagatccagGaccaggatctccgataccag	14	6	11	10	1	1	2	0	1	1	2	3	6	2	4	4	3	2	0	4	3	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:34092279G>A	uc002xcm.2	+	31	6753	c.6082G>A	c.(6082-6084)GAC>AAC	p.D2028N	CEP250_uc010zve.1_Missense_Mutation_p.D1396N	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	2028	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TGAGATCCAGGACCAGGATCT	0.607													6	26					0	0	0	0	A	34092279	A	A	34092279	3	1	5	1	0	0	0	0	1	0	0	0	3267	1174	41	2	6188	2	CEP250	20	34092279	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	10125909	34092279	28933241	468	1604											
DLGAP4	22839	broad.mit.edu	37	chr20	35060934	35060934	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgccccaccacccccgcccGcacccccagccacctgcccc	5	2	5	29	2	0	0	0	0	0	0	0	0	0	0	12	0	3	1	12	0	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:35060934G>A	uc002xff.2	+	3	1249	c.814G>A	c.(814-816)GCA>ACA	p.A272T	DLGAP4_uc010zvp.1_Missense_Mutation_p.A272T	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	272	Poly-Pro.				cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				ACCCCCGCCCGCACCCCCAGC	0.627													10	19					0	0	0	0	A	35060934	A	A	35060934	3	1	5	1	0	0	0	0	1	0	0	0	4584	1087	38	1	816	1	DLGAP4	20	35060934	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	968655	35060934	27964586	469	1605											
TGM2	7052	broad.mit.edu	37	chr20	36775222	36775222	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacgctgccgatccaggaCatggggctgacgccgtcccc	6	6	12	17	4	0	1	0	1	0	0	3	3	3	2	6	3	1	2	6	3	0	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:36775222C>A	uc002xhr.2	-	6	856	c.756G>T	c.(754-756)ATG>ATT	p.M252I	TGM2_uc010zvx.1_Missense_Mutation_p.M171I|TGM2_uc010zvy.1_Missense_Mutation_p.M192I|TGM2_uc002xhs.1_Missense_Mutation_p.M228I|TGM2_uc002xht.2_Missense_Mutation_p.M252I|TGM2_uc002xhu.3_Missense_Mutation_p.M252I	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	252					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	CGATCCAGGACATGGGGCTGA	0.657													75	62					1.3515e-34	1.82713e-34	1	0	A	36775222	A	A	36775222	3	1	5	1	0	0	0	0	1	0	0	0	15896	478	17	4	1371	4	TGM2	20	36775222	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1714288	36775222	26250298	470	1606											
ACTR5	79913	broad.mit.edu	37	chr20	37395021	37395021	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttcagtacattctggacagGtgagacagcgaatctgcttt	10	12	10	9	1	3	1	1	1	2	1	3	4	3	2	0	2	3	2	0	2	2	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:37395021G>A	uc002xjd.2	+	7	1458	c.1433_splice	c.e7+1	p.R478_splice		NM_024855	NP_079131	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog						DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding				0		Myeloproliferative disorder(115;0.00878)				TTCTGGACAGGTGAGACAGCG	0.433													362	140					0	0	0	0	A	37395021	A	A	37395021	5	1	5	1	0	0	0	0	0	0	1	0	215	1275	44	4	1460	4	ACTR5	20	37395021	Splice_Site	SNP	G	TCGA-BA-4078-01A-01D-1434-08	619799	37395021	25630499	471	1607											
YTHDF1	54915	broad.mit.edu	37	chr20	61833966	61833966	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accccacaaaaatgcccactCccattgacgctgaagagcag	14	5	7	15	1	0	3	0	2	0	1	1	3	1	3	4	0	2	2	4	0	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr20:61833966C>A	uc002yeh.2	-	4	1620	c.1326G>T	c.(1324-1326)GGG>GGT	p.G442G	YTHDF1_uc011aaq.1_Silent_p.G392G	NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	442	YTH.									ovary(2)	2						AATGCCCACTCCCATTGACGC	0.607													80	36					5.36554e-22	6.43865e-22	1	0	A	61833966	A	A	61833966	2	1	5	1	0	0	0	0	0	0	0	1	17566	842	30	2		2	YTHDF1	20	61833966	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	24438945	61833966	1191554	472	1608											
BAGE2	85319	broad.mit.edu	37	chr21	11058319	11058319	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagtgcttacaaaatgcaCatcgctgaaaggggtaaagg	16	7	11	7	1	0	1	0	1	0	0	1	1	0	1	0	3	3	4	0	3	7	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr21:11058319C>T	uc002yit.1	-	3	329	c.121G>A	c.(121-123)GTG>ATG	p.V41M	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACAAAATGCACATCGCTGAAA	0.388													25	253					0	0	0	0	T	11058319	T	T	11058319	3	4	5	1	0	0	0	0	1	0	0	0	1294	478	17	4	216	4	BAGE2	21	11058319	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08		11058319	37071576	473	1609											
KRTAP10-8	386681	broad.mit.edu	37	chr21	46032693	46032693	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcctgctgtgtgcctgtcCcctcctgttgtgtccctgcc	0	14	10	17	0	0	0	0	0	0	0	3	0	3	0	7	0	4	2	7	0	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr21:46032693C>T	uc002zfo.1	+	1	698	c.676C>T	c.(676-678)CCC>TCC	p.P226S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198695	NP_941968	P60410	KR108_HUMAN	keratin associated protein 10-8	226	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|breast(1)	2						tgtgcctgtcccctcctgttg	0.204													62	73					0	0	0	0	T	46032693	T	T	46032693	3	4	5	1	0	0	0	0	1	0	0	0	8554	623	22	4	678	4	KRTAP10-8	21	46032693	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	34974374	46032693	2097202	474	1610											
USP18	11274	broad.mit.edu	37	chr22	18643000	18643000	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactccttgattcaggtgttCgtaatgaatgtggacttcac	10	14	9	8	1	2	2	2	2	0	0	4	3	3	3	1	2	1	2	1	2	3	5	rs138144879	byFrequency	TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr22:18643000C>A	uc002zny.2	+	3	557	c.219C>A	c.(217-219)TTC>TTA	p.F73L		NM_017414	NP_059110	Q9UMW8	UBP18_HUMAN	ubiquitin specific protease 18	73					regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway|ubiquitin-dependent protein catabolic process	cytosol|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)	1						TTCAGGTGTTCGTAATGAATG	0.373													260	31					2.59669e-106	4.00959e-106	1	0	A	18643000	A	A	18643000	3	1	5	1	0	0	0	0	1	0	0	0	17117	883	31	3	225	3	USP18	22	18643000	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08		18643000	32661566	475	1611											
APOL3	80833	broad.mit.edu	37	chr22	36541544	36541544	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcaattcagccgcagtcacGaatctcttccaggcttcatt	9	11	8	13	2	4	0	3	0	1	0	6	1	5	0	2	2	1	3	2	2	2	4	rs61731691		TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr22:36541544G>A	uc003aot.2	-	2	365	c.327C>T	c.(325-327)TTC>TTT	p.F109F	APOL3_uc003aoq.2_Silent_p.F38F|APOL3_uc003aor.2_Silent_p.F38F|APOL3_uc003aos.2_Silent_p.F38F|APOL3_uc003aou.2_5'UTR|APOL3_uc003aov.2_5'UTR	NM_145640	NP_663615	O95236	APOL3_HUMAN	apolipoprotein L3 isoform 1	109					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity				0						CCGCAGTCACGAATCTCTTCC	0.552													50	105					0	0	0	0	A	36541544	A	A	36541544	2	1	5	1	0	0	0	0	0	0	0	1	807	1049	37	1		1	APOL3	22	36541544	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	17898544	36541544	14763022	476	1612											
C1QTNF6	114904	broad.mit.edu	37	chr22	37584249	37584249	+	5'Flank	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcacggaccctgagccacTgcatggcctctggctccttg	6	9	10	16	1	2	1	1	1	1	0	3	2	3	2	4	3	2	2	4	3	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chr22:37584249T>C	uc003aqw.1	-						C1QTNF6_uc003aqx.1_Missense_Mutation_p.Q2R|C1QTNF6_uc003aqy.1_Missense_Mutation_p.Q2R|C1QTNF6_uc003aqz.1_RNA	NM_182486	NP_872292	Q9BXI9	C1QT6_HUMAN	C1q and tumor necrosis factor related protein 6							collagen					0						CCTGAGCCACTGCATGGCCTC	0.547													123	20					0	0	0	0	C	37584249	C	C	37584249	1	2	5	0	1	0	0	0	0	0	0	0	1976	1580	55	5		5	C1QTNF6	22	37584249	5'Flank	SNP	T	TCGA-BA-4078-01A-01D-1434-08	1042705	37584249	13720317	477	1613											
CSF2RA	1438	broad.mit.edu	37	chrX	1407468	1407468	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttgtctgcatgaaggagtCacatttgaggttcacgtgaa	11	13	11	6	1	3	3	2	3	1	0	3	4	3	4	0	2	1	2	0	2	2	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:1407468C>T	uc010nct.2	+	6	598	c.276C>T	c.(274-276)GTC>GTT	p.V92V	CSF2RA_uc011mhb.1_Silent_p.V92V|CSF2RA_uc004cpq.2_Silent_p.V92V|CSF2RA_uc004cpn.2_Silent_p.V92V|CSF2RA_uc004cpo.2_Silent_p.V92V|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_5'UTR|CSF2RA_uc004cpp.2_Silent_p.V92V|CSF2RA_uc010ncv.2_Silent_p.V92V|CSF2RA_uc004cpr.2_Silent_p.V92V	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	92	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ATGAAGGAGTCACATTTGAGG	0.423													163	292					0	0	0	0	T	1407468	T	T	1407468	2	4	5	1	0	0	0	0	0	0	0	1	3951	813	29	2		2	CSF2RA	23	1407468	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08		1407468	153863092	478	1614											
IL3RA	3563	broad.mit.edu	37	chrX	1464240	1464240	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaatcacgaacctaaggatGaaagcaaaggctcagcagtt	16	6	9	10	1	2	1	2	1	0	0	2	3	2	2	2	2	3	4	2	2	5	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:1464240G>C	uc004cps.2	+	3	445	c.96G>C	c.(94-96)ATG>ATC	p.M32I	IL3RA_uc011mhd.1_Intron	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	32	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ACCTAAGGATGAAAGCAAAGG	0.443													5	353					0	0	0	0	C	1464240	C	C	1464240	3	2	5	1	0	0	0	0	1	0	0	0	7734	1290	45	2	102	2	IL3RA	23	1464240	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	56772	1464240	153806320	479	1615											
NLGN4X	57502	broad.mit.edu	37	chrX	6069249	6069249	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttctgggggctgaaaccGcctctctccagtggggggtg	4	9	18	10	1	2	1	0	1	2	0	4	1	3	1	3	6	1	2	3	6	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:6069249G>T	uc010ndh.2	-	2	760	c.259C>A	c.(259-261)CGG>AGG	p.R87R	NLGN4X_uc004crp.2_Silent_p.R87R|NLGN4X_uc004crq.2_Silent_p.R87R|NLGN4X_uc010ndi.2_Silent_p.R87R|NLGN4X_uc004crr.2_Silent_p.R87R|NLGN4X_uc010ndj.2_Silent_p.R87R	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	87	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GGCTGAAACCGCCTCTCTCCA	0.572													75	12					6.20995e-33	8.27118e-33	1	0	T	6069249	T	T	6069249	2	4	5	1	0	0	0	0	0	0	0	1	10518	1086	38	3		3	NLGN4X	23	6069249	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	4605009	6069249	149201311	480	1616											
RPS6KA3	6197	broad.mit.edu	37	chrX	20195158	20195159	+	Frame_Shift_Del	DEL	CT	-	-																															tgaaaagcattcgtaaaagaCtctgcgcttcaggactcaaa																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:20195158_20195159delCT	uc004czu.2	-	11	889_890	c.889_890delAG	c.(889-891)AGTfs	p.S297fs	RPS6KA3_uc011mjk.1_Frame_Shift_Del_p.S268fs|RPS6KA3_uc004czv.2_Frame_Shift_Del_p.S285fs|RPS6KA3_uc011mjl.1_Frame_Shift_Del_p.S269fs|RPS6KA3_uc011mjm.1_Frame_Shift_Del_p.S269fs	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	297	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						TCGTAAAAGACTCTGCGCTTCA	0.307													---	---	---								-	20195159	-	-	20195158	7	5	5	1	0	1	0	1	0	0	0	0	13717	565	20	0	1380	0	RPS6KA3	23	20195158	Frame_Shift_Del	DEL	CT	TCGA-BA-4078-01A-01D-1434-08	14125909	20195158	135075402	481	1617											
MAGEB4	4115	broad.mit.edu	37	chrX	30260672	30260672	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaatgctgaagatcatcagCaaaaagtacaaggagcactt	18	7	9	7	0	2	2	2	1	0	1	2	4	2	3	0	1	4	4	0	1	6	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:30260672C>T	uc004dcb.2	+	1	504	c.420C>T	c.(418-420)AGC>AGT	p.S140S	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	140	MAGE.									ovary(1)	1						AGATCATCAGCAAAAAGTACA	0.473													25	3					0	0	0	0	T	30260672	T	T	30260672	2	4	5	1	0	0	0	0	0	0	0	1	9231	709	25	4		4	MAGEB4	23	30260672	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	10065514	30260672	125009888	482	1618											
DMD	1756	broad.mit.edu	37	chrX	31893375	31893375	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gattcctaataggagataacCacagcagcagatgatttaac	16	9	8	8	0	0	3	0	1	0	2	1	5	1	3	2	1	4	2	2	1	4	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:31893375C>G	uc004dda.1	-	48	7272	c.7028G>C	c.(7027-7029)TGG>TCG	p.W2343S	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.W999S|DMD_uc004dcx.2_Missense_Mutation_p.W1002S|DMD_uc004dcz.2_Missense_Mutation_p.W2220S|DMD_uc004dcy.1_Missense_Mutation_p.W2339S|DMD_uc004ddb.1_Missense_Mutation_p.W2335S|DMD_uc010ngn.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2343			Missing (in DMD).		muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGGAGATAACCACAGCAGCAG	0.368													22	7					0	0	0	0	G	31893375	G	G	31893375	3	3	5	1	0	0	0	0	1	0	0	0	4602	595	21	4	4305	4	DMD	23	31893375	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	1632703	31893375	123377185	483	1619											
FAM47C	442444	broad.mit.edu	37	chrX	37027498	37027498	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagagcctcccaagactctgGtgtccagtctccacccagag	9	7	9	16	0	2	3	0	0	2	3	5	3	4	3	5	1	1	0	5	1	1	0			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:37027498G>T	uc004ddl.1	+	1	1029	c.1015G>T	c.(1015-1017)GTG>TTG	p.V339L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	339										ovary(3)	3						CAAGACTCTGGTGTCCAGTCT	0.622													88	22					1.07111e-62	1.63389e-62	1	0	T	37027498	T	T	37027498	3	4	5	1	0	0	0	0	1	0	0	0	5603	1261	44	4	1017	4	FAM47C	23	37027498	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	5134123	37027498	118243062	484	1620											
WDR45	11152	broad.mit.edu	37	chrX	48933527	48933527	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccactggacggctcaccaCaagttgcagactcccacact	10	7	8	16	1	1	1	1	0	0	1	3	2	3	2	3	2	1	3	3	2	1	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:48933527C>G	uc004dmk.1	-	7	686	c.514G>C	c.(514-516)GTG>CTG	p.V172L	PRAF2_uc004dmi.2_5'Flank|PRAF2_uc011mmt.1_Missense_Mutation_p.V70L|WDR45_uc004dmj.1_Missense_Mutation_p.V133L|WDR45_uc004dml.1_Missense_Mutation_p.V173L|WDR45_uc004dmm.1_Missense_Mutation_p.V137L|WDR45_uc010nim.1_Missense_Mutation_p.V172L|WDR45_uc004dmn.1_Missense_Mutation_p.V63L|WDR45_uc004dmo.1_Missense_Mutation_p.V195L|WDR45_uc004dmp.1_Missense_Mutation_p.V173L	NM_001029896	NP_001025067	Q9Y484	WIPI4_HUMAN	WD repeat domain 45 isoform 2	172					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1						CGGCTCACCACAAGTTGCAGA	0.597													31	3					0	0	0	0	G	48933527	G	G	48933527	3	3	5	1	0	0	0	0	1	0	0	0	17365	478	17	4	588	4	WDR45	23	48933527	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	11906029	48933527	106337033	485	1621											
PAGE4	9506	broad.mit.edu	37	chrX	49597193	49597193	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcggagtgagcgtggagatGgctctgatgtaaaagagaag	12	8	16	5	2	1	4	0	2	1	2	2	7	1	5	0	3	1	2	0	3	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:49597193G>T	uc004don.1	+	4	311	c.232G>T	c.(232-234)GGC>TGC	p.G78C		NM_007003	NP_008934	O60829	GAGC1_HUMAN	G antigen, family C, 1	78											0	Ovarian(276;0.236)					GCGTGGAGATGGCTCTGATGT	0.388													57	12					4.13886e-29	5.3432e-29	1	0	T	49597193	T	T	49597193	3	4	5	1	0	0	0	0	1	0	0	0	11446	1348	47	4	242	4	PAGE4	23	49597193	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	663666	49597193	105673367	486	1622											
WNK3	65267	broad.mit.edu	37	chrX	54359590	54359590	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgcagctcacaccaagcaaCctcaacccatgtttcagtgt	11	9	6	15	0	3	0	3	0	0	0	3	0	3	0	3	0	5	4	3	0	3	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:54359590C>A	uc004dtd.1	-	2	956	c.517G>T	c.(517-519)GTT>TTT	p.V173F	WNK3_uc004dtc.1_Missense_Mutation_p.V173F	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	173	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						CACCAAGCAACCTCAACCCAT	0.393													83	22					3.16549e-35	4.31658e-35	1	0	A	54359590	A	A	54359590	3	1	5	1	0	0	0	0	1	0	0	0	17447	507	18	4	4977	4	WNK3	23	54359590	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	4762397	54359590	100910970	487	1623											
MSN	4478	broad.mit.edu	37	chrX	64959590	64959590	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttcccatacatcctcacaGgccctcacttcggagctggc	7	10	8	16	1	2	0	2	0	0	0	5	1	4	1	3	3	2	2	3	3	1	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:64959590G>T	uc004dwf.2	+	13	1768	c.1570_splice	c.e13-1	p.A524_splice		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin						leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						CATCCTCACAGGCCCTCACTT	0.483			T	ALK	ALCL								54	15					2.64514e-33	3.53058e-33	1	0	T	64959590	T	T	64959590	5	4	5	1	0	0	0	0	0	0	1	0	9938	1014	35	4	1619	4	MSN	23	64959590	Splice_Site	SNP	G	TCGA-BA-4078-01A-01D-1434-08	10600000	64959590	90310970	488	1624											
EDA2R	60401	broad.mit.edu	37	chrX	65824895	65824895	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaagcaagctcacctgggCaaacagtccccacagacagc	15	4	8	14	0	1	1	1	0	0	1	2	1	2	1	3	1	4	3	3	1	4	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:65824895C>T	uc004dwq.2	-	2	272	c.261G>A	c.(259-261)TTG>TTA	p.L87L	EDA2R_uc004dwr.2_Silent_p.L87L|EDA2R_uc004dws.2_Silent_p.L87L|EDA2R_uc011mpb.1_RNA|EDA2R_uc011mpc.1_Intron|EDA2R_uc010nkt.1_Silent_p.L87L|EDA2R_uc004dwt.1_Silent_p.L87L	NM_021783	NP_068555	Q9HAV5	TNR27_HUMAN	X-linked ectodysplasin receptor	87	TNFR-Cys 3.|Extracellular (Potential).				cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			upper_aerodigestive_tract(1)	1						CTCACCTGGGCAAACAGTCCC	0.488													10	2					0	0	0	0	T	65824895	T	T	65824895	2	4	5	1	0	0	0	0	0	0	0	1	4926	709	25	4		4	EDA2R	23	65824895	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	865305	65824895	89445665	489	1625											
KIAA2022	340533	broad.mit.edu	37	chrX	73961161	73961161	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtaatttgaggggaaagactAggggtgtccggtggggacat	10	9	18	4	1	0	2	0	1	0	1	1	4	1	4	1	7	0	1	1	7	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:73961161A>G	uc004eby.2	-	3	3848	c.3231T>C	c.(3229-3231)CCT>CCC	p.P1077P		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1077					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GGGAAAGACTAGGGGTGTCCG	0.502													102	34					0	0	0	0	G	73961161	G	G	73961161	2	3	5	1	0	0	0	0	0	0	0	1	8308	407	15	5		5	KIAA2022	23	73961161	Silent	SNP	A	TCGA-BA-4078-01A-01D-1434-08	8136266	73961161	81309399	490	1626											
RPS6KA6	27330	broad.mit.edu	37	chrX	83371245	83371245	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacttaacttacatcccagtCaatatttgcaaaaaacagat	17	12	3	9	0	1	1	1	0	0	1	2	1	2	1	1	0	5	1	1	0	8	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:83371245C>T	uc004eej.1	-	12	1077	c.1000G>A	c.(1000-1002)GAC>AAC	p.D334N	RPS6KA6_uc011mqt.1_Missense_Mutation_p.D334N|RPS6KA6_uc011mqu.1_Missense_Mutation_p.D231N	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	334	AGC-kinase C-terminal.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						ACATCCCAGTCAATATTTGCA	0.234													28	2					0	0	0	0	T	83371245	T	T	83371245	3	4	5	1	0	0	0	0	1	0	0	0	13720	826	29	2	1281	2	RPS6KA6	23	83371245	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	9410084	83371245	71899315	491	1627											
HDX	139324	broad.mit.edu	37	chrX	83616510	83616510	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaacatttaattcagttgcCacagcttcaattttctctct	10	17	3	11	0	5	0	3	0	2	0	6	0	5	0	1	0	3	2	1	0	3	7			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:83616510C>G	uc004eek.1	-	5	1525	c.1416G>C	c.(1414-1416)GTG>GTC	p.V472V	HDX_uc011mqv.1_Silent_p.V472V|HDX_uc004eel.1_Silent_p.V414V	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	472	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						ATTCAGTTGCCACAGCTTCAA	0.393													27	8					0	0	0	0	G	83616510	G	G	83616510	2	3	5	1	0	0	0	0	0	0	0	1	7065	581	21	4		4	HDX	23	83616510	Silent	SNP	C	TCGA-BA-4078-01A-01D-1434-08	245265	83616510	71654050	492	1628											
POF1B	79983	broad.mit.edu	37	chrX	84634342	84634342	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttttttctggaggctgctGggcttggcttgactgatggt	4	17	14	6	0	1	2	0	2	1	0	1	3	1	3	0	5	1	4	0	5	0	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:84634342G>T	uc004eer.2	-	2	264	c.118C>A	c.(118-120)CAG>AAG	p.Q40K	POF1B_uc004ees.2_Missense_Mutation_p.Q40K	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	40							actin binding				0						GGAGGCTGCTGGGCTTGGCTT	0.577													34	4					3.21399e-22	3.89388e-22	1	0	T	84634342	T	T	84634342	3	4	5	1	0	0	0	0	1	0	0	0	12237	1357	47	4	1715	4	POF1B	23	84634342	Missense_Mutation	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1017832	84634342	70636218	493	1629											
DACH2	117154	broad.mit.edu	37	chrX	85994839	85994839	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcccacaccagcagcagTgtgtccagctctccctctca	7	10	6	18	0	3	0	1	0	3	0	7	0	5	0	4	0	3	3	4	0	0	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:85994839T>A	uc004eew.2	+	7	1364	c.1194T>A	c.(1192-1194)AGT>AGA	p.S398R	DACH2_uc004eex.2_Missense_Mutation_p.S385R|DACH2_uc010nmq.2_Missense_Mutation_p.S264R|DACH2_uc011mra.1_Missense_Mutation_p.S231R|DACH2_uc010nmr.2_Missense_Mutation_p.S179R|DACH2_uc004eey.2_Missense_Mutation_p.S81R|DACH2_uc004eez.2_Missense_Mutation_p.S81R	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						CCAGCAGCAGTGTGTCCAGCT	0.458													21	3					0	0	0	0	A	85994839	A	A	85994839	3	1	5	1	0	0	0	0	1	0	0	0	4238	1693	59	5	1220	5	DACH2	23	85994839	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	1360497	85994839	69275721	494	1630											
NOX1	27035	broad.mit.edu	37	chrX	100117442	100117442	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaggtggtgagtataccagaAgacttcaaaataactcctcc	15	9	8	9	0	1	3	1	1	0	2	3	3	3	3	3	2	2	1	3	2	7	4			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:100117442A>G	uc004egj.2	-	6	816	c.610T>C	c.(610-612)TTC>CTC	p.F204L	uc010nnf.2_Intron|NOX1_uc004egl.3_Missense_Mutation_p.F204L|NOX1_uc010nne.2_Missense_Mutation_p.F167L	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	204	Cytoplasmic (Potential).|Ferric oxidoreductase.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						GTATACCAGAAGACTTCAAAA	0.463													218	48					0	0	0	0	G	100117442	G	G	100117442	3	3	5	1	0	0	0	0	1	0	0	0	10610	72	3	5	1116	5	NOX1	23	100117442	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	14122603	100117442	55153118	495	1631											
BHLHB9	80823	broad.mit.edu	37	chrX	102003885	102003885	+	Translation_Start_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taggacacattgagaaccaaGgccaagactggacagggcca	15	4	12	10	0	0	2	0	1	0	2	0	5	0	4	3	4	1	0	3	4	4	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:102003885G>T	uc010nog.2	+	4	533	c.-38G>T	c.(-40--36)AAGGC>AATGC		BHLHB9_uc011mrq.1_Translation_Start_Site|BHLHB9_uc011mrr.1_Translation_Start_Site|BHLHB9_uc011mrs.1_Translation_Start_Site|BHLHB9_uc011mrt.1_Translation_Start_Site|BHLHB9_uc004ejo.2_Translation_Start_Site|BHLHB9_uc011mru.1_Translation_Start_Site|BHLHB9_uc011mrv.1_Translation_Start_Site	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class							cytoplasm|nucleus	binding			ovary(2)	2						TGAGAACCAAGGCCAAGACTG	0.463													26	4					6.32553e-13	7.05325e-13	1	0	T	102003885	T	T	102003885	1	4	5	1	0	0	0	0	0	0	0	0	1423	1015	35	4		4	BHLHB9	23	102003885	Translation_Start_Site	SNP	G	TCGA-BA-4078-01A-01D-1434-08	1886443	102003885	53266675	496	1632											
IL1RAPL2	26280	broad.mit.edu	37	chrX	104478565	104478565	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagagaatgaatcaggcctGtgctacaacagcaggatccg	13	6	12	10	1	1	2	1	1	0	1	2	4	2	3	2	2	4	3	2	2	4	1			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:104478565G>A	uc004elz.1	+	4	1176	c.420G>A	c.(418-420)CTG>CTA	p.L140L		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	140	Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						AATCAGGCCTGTGCTACAACA	0.403													152	39					0	0	0	0	A	104478565	A	A	104478565	2	1	5	1	0	0	0	0	0	0	0	1	7701	1364	48	4		4	IL1RAPL2	23	104478565	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08	2474680	104478565	50791995	497	1633											
GRIA3	2892	broad.mit.edu	37	chrX	122598930	122598930	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaatctggattccaaaggctAtggtgtggcaacccctaaag	13	9	10	9	0	1	0	0	0	1	0	2	1	2	1	3	4	1	2	3	4	6	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:122598930A>T	uc004etq.3	+	14	2584	c.2291A>T	c.(2290-2292)TAT>TTT	p.Y764F	GRIA3_uc004etr.3_Missense_Mutation_p.Y764F|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	764	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	TCCAAAGGCTATGGTGTGGCA	0.428													91	20					0	0	0	0	T	122598930	T	T	122598930	3	4	5	1	0	0	0	0	1	0	0	0	6808	449	16	5	2341	5	GRIA3	23	122598930	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	18120365	122598930	32671630	498	1634											
GPR112	139378	broad.mit.edu	37	chrX	135439903	135439903	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaaatggctacaatttcctAtgtaccatacaggtaggaag	15	10	9	7	0	0	1	0	0	0	1	1	2	1	2	2	3	3	3	2	3	8	6			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:135439903A>T	uc004ezu.1	+	10	7259	c.6968A>T	c.(6967-6969)TAT>TTT	p.Y2323F	GPR112_uc010nsb.1_Missense_Mutation_p.Y2118F|GPR112_uc010nsc.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2323	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACAATTTCCTATGTACCATAC	0.368													147	35					0	0	0	0	T	135439903	T	T	135439903	3	4	5	1	0	0	0	0	1	0	0	0	6667	449	16	5	6994	5	GPR112	23	135439903	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	12840973	135439903	19830657	499	1635											
SLITRK4	139065	broad.mit.edu	37	chrX	142717687	142717687	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgtctcccttaatcactgtaAtttgattgctgcctaaatga	10	15	6	10	1	2	2	1	2	1	0	3	2	2	2	2	0	2	2	2	0	4	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:142717687A>G	uc004fbx.2	-	2	1614	c.1238T>C	c.(1237-1239)ATT>ACT	p.I413T	SLITRK4_uc004fby.2_Missense_Mutation_p.I413T	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	413	Extracellular (Potential).|LRR 8.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AATCACTGTAATTTGATTGCT	0.388													131	25					0	0	0	0	G	142717687	G	G	142717687	3	3	5	1	0	0	0	0	1	0	0	0	14809	101	4	5	1279	5	SLITRK4	23	142717687	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	7277784	142717687	12552873	500	1636											
SLITRK4	139065	broad.mit.edu	37	chrX	142717956	142717957	+	Frame_Shift_Ins	INS	-	T	T																															caatctgactgagattgcggINSttggagagggctttgcctgc																										TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:142717956_142717957insT	uc004fbx.2	-	2	1344_1345	c.968_969insA	c.(967-969)AACfs	p.N323fs	SLITRK4_uc004fby.2_Frame_Shift_Ins_p.N323fs	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	323	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGATTGCGGTTGGAGAGGGC	0.465													---	---	---								T	142717957	T	T	142717956	7	5	5	1	0	1	1	0	0	0	0	0	14809	1252	44	0	1548	0	SLITRK4	23	142717956	Frame_Shift_Ins	INS	-	TCGA-BA-4078-01A-01D-1434-08	269	142717956	12552604	501	1637											
SLITRK2	84631	broad.mit.edu	37	chrX	144905948	144905948	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taagctcctttcaattacagTatgggtcttacaacactgag	12	13	7	9	0	2	1	1	1	1	0	3	1	3	1	1	1	4	2	1	1	6	5			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:144905948T>A	uc004fcd.2	+	5	2995	c.2005T>A	c.(2005-2007)TAT>AAT	p.Y669N	SLITRK2_uc010nsp.2_Missense_Mutation_p.Y669N|SLITRK2_uc010nso.2_Missense_Mutation_p.Y669N|SLITRK2_uc011mwq.1_Missense_Mutation_p.Y669N|SLITRK2_uc011mwr.1_Missense_Mutation_p.Y669N|SLITRK2_uc011mws.1_Missense_Mutation_p.Y669N|SLITRK2_uc004fcg.2_Missense_Mutation_p.Y669N|SLITRK2_uc011mwt.1_Missense_Mutation_p.Y669N|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	669	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TCAATTACAGTATGGGTCTTA	0.478													85	15					0	0	0	0	A	144905948	A	A	144905948	3	1	5	1	0	0	0	0	1	0	0	0	14807	1638	57	5	2007	5	SLITRK2	23	144905948	Missense_Mutation	SNP	T	TCGA-BA-4078-01A-01D-1434-08	2187992	144905948	10364612	502	1638											
GABRA3	2556	broad.mit.edu	37	chrX	151514091	151514091	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccggttgtcatagccgtccAgaagacgatccaagattctg	10	9	11	11	3	2	3	1	0	1	3	4	4	4	3	4	1	1	1	4	1	3	3			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:151514091A>G	uc010ntk.1	-	3	464	c.224T>C	c.(223-225)CTG>CCG	p.L75P		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	75	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATAGCCGTCCAGAAGACGATC	0.473													67	14					0	0	0	0	G	151514091	G	G	151514091	3	3	5	1	0	0	0	0	1	0	0	0	6196	188	7	5	1286	5	GABRA3	23	151514091	Missense_Mutation	SNP	A	TCGA-BA-4078-01A-01D-1434-08	6608143	151514091	3756469	503	1639											
MAGEA6	4105	broad.mit.edu	37	chrX	151869846	151869846	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cggccacgtgtacatctttgCcacctgcctgggcctctcct	4	11	9	17	2	2	0	0	0	2	0	3	0	2	0	6	2	3	1	6	2	1	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrX:151869846C>G	uc004ffq.1	+	3	730	c.536C>G	c.(535-537)GCC>GGC	p.A179G	MAGEA6_uc004ffr.1_Missense_Mutation_p.A179G|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	179	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					TACATCTTTGCCACCTGCCTG	0.527													102	18					0	0	0	0	G	151869846	G	G	151869846	3	3	5	1	0	0	0	0	1	0	0	0	9221	739	26	4	538	4	MAGEA6	23	151869846	Missense_Mutation	SNP	C	TCGA-BA-4078-01A-01D-1434-08	355755	151869846	3400714	504	1640											
RPS4Y2	140032	broad.mit.edu	37	chrY	22930714	22930714	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagttgtgcaaagtgaggaaGattactgtggggacaaaggg	14	8	16	3	0	0	2	0	1	0	1	0	4	0	4	0	4	2	2	0	4	5	2			TCGA-BA-4078-01A-01D-1434-08	TCGA-BA-4078-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	f02d0332-d7c8-4d2a-98ca-dbe7826437ae	adae384c-a4b5-4ce7-bb4c-cc0762d7a807	g.chrY:22930714G>A	uc011nbb.1	+	5	480	c.384G>A	c.(382-384)AAG>AAA	p.K128K		NM_001039567	NP_001034656	Q8TD47	RS4Y2_HUMAN	ribosomal protein S4, Y-linked 2	128					translation	ribosome	rRNA binding|structural constituent of ribosome				0						AAGTGAGGAAGATTACTGTGG	0.438													49	8					0	0	0	0	A	22930714	A	A	22930714	2	1	5	1	0	0	0	0	0	0	0	1	13712	933	33	2		2	RPS4Y2	24	22930714	Silent	SNP	G	TCGA-BA-4078-01A-01D-1434-08		22930714	36442852	505	1641											
HTR1D	3352	broad.mit.edu	37	chr1	23520575	23520575	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actgtggccagtgtgatgacGgaaaggaccacggcaaggga	12	5	16	8	2	0	2	0	2	0	0	0	5	0	5	2	5	0	1	2	5	2	0			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:23520575G>A	uc001bgn.2	-	1	648	c.138C>T	c.(136-138)TCC>TCT	p.S46S		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	46	Helical; Name=1; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	GTGTGATGACGGAAAGGACCA	0.572													91	101					0	0	0	0	A	23520575	A	A	23520575	2	1	6	1	0	0	0	0	0	0	0	1	7477	1103	39	1		1	HTR1D	1	23520575	Silent	SNP	G	TCGA-BA-5149-01A-01D-1512-08		23520575	225730046	1	1642											
S100PBP	64766	broad.mit.edu	37	chr1	33295639	33295639	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcaggagtgtcattgctcAtatagaagacccagaggaca	13	9	10	9	0	3	3	3	0	1	3	4	5	3	5	1	2	1	1	1	2	3	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:33295639A>C	uc001bvz.2	+	5	1272	c.995A>C	c.(994-996)CAT>CCT	p.H332P	S100PBP_uc001bwa.1_Missense_Mutation_p.H331P|S100PBP_uc001bwb.1_Missense_Mutation_p.H332P|S100PBP_uc001bwc.2_Missense_Mutation_p.H332P|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	332						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GTCATTGCTCATATAGAAGAC	0.403													29	140					0	0	0	0	C	33295639	C	C	33295639	3	2	6	1	0	0	0	0	1	0	0	0	13856	217	8	5	1005	5	S100PBP	1	33295639	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	9775064	33295639	215954982	2	1643											
WLS	79971	broad.mit.edu	37	chr1	68613869	68613869	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatactgtagaagggattcgTgagttgtacccctctacaaa	12	11	10	8	1	1	2	0	1	1	1	2	4	1	3	2	1	3	3	2	1	6	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:68613869T>G	uc001def.1	-	8	1355	c.1084A>C	c.(1084-1086)ACG>CCG	p.T362P	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Missense_Mutation_p.T360P|WLS_uc001deg.1_Missense_Mutation_p.T271P|WLS_uc009wbf.1_Missense_Mutation_p.T317P	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	362	Lumenal (Potential).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						AAGGGATTCGTGAGTTGTACC	0.443													21	183					0	0	0	0	G	68613869	G	G	68613869	3	3	6	1	0	0	0	0	1	0	0	0	17444	1696	59	5	687	5	WLS	1	68613869	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	35318230	68613869	180636752	3	1644											
CTH	1491	broad.mit.edu	37	chr1	70881666	70881666	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aatatagccgttctggaaatCccactaggaattgccttgaa	13	11	8	9	1	1	1	0	1	1	0	2	3	2	3	3	2	2	1	3	2	7	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:70881666C>G	uc001dfd.2	+	2	340	c.196C>G	c.(196-198)CCC>GCC	p.P66A	CTH_uc009wbl.1_RNA|CTH_uc001dfe.2_Missense_Mutation_p.P66A|CTH_uc010oqq.1_Missense_Mutation_p.P66A	NM_001902	NP_001893	P32929	CGL_HUMAN	cystathionase isoform 1	66					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			lung(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	TTCTGGAAATCCCACTAGGAA	0.358													15	95					0	0	0	0	G	70881666	G	G	70881666	3	3	6	1	0	0	0	0	1	0	0	0	4026	855	30	2	202	2	CTH	1	70881666	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	2267797	70881666	178368955	4	1645											
CCBL2	56267	broad.mit.edu	37	chr1	89427140	89427140	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttactttccagttcttgaGgatctaatgtccagtcagaa	11	15	7	8	0	3	2	1	1	2	1	5	3	5	3	2	1	1	1	2	1	3	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:89427140G>C	uc001dmp.2	-	7	967	c.590C>G	c.(589-591)CCT>CGT	p.P197R	CCBL2_uc001dmq.2_Missense_Mutation_p.P163R|CCBL2_uc001dmr.2_Missense_Mutation_p.P33R	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	197					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CAGTTCTTGAGGATCTAATGT	0.323													40	209					0	0	0	0	C	89427140	C	C	89427140	3	2	6	1	0	0	0	0	1	0	0	0	2745	1000	35	4	806	4	CCBL2	1	89427140	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	18545474	89427140	159823481	5	1646											
FLG	2312	broad.mit.edu	37	chr1	152281203	152281203	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacactgactgtgtgtctgaGtcttctgaatgtccctcact	7	14	9	11	0	4	3	1	3	3	0	5	4	5	3	1	0	0	0	1	0	1	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:152281203G>C	uc001ezu.1	-	3	6195	c.6159C>G	c.(6157-6159)GAC>GAG	p.D2053E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2053	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGTGTCTGAGTCTTCTGAAT	0.562									Ichthyosis				17	798					0	0	0	0	C	152281203	C	C	152281203	3	2	6	1	0	0	0	0	1	0	0	0	5954	1020	36	4	6030	4	FLG	1	152281203	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	62854063	152281203	96969418	6	1647			1	2		2	2	22	G		9.700175e-05
FLG	2312	broad.mit.edu	37	chr1	152281224	152281224	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctgaatgtccctcactGtcactggcctgactaccact	7	13	6	15	0	4	2	2	2	2	0	5	2	5	2	3	1	1	0	3	1	2	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:152281224G>A	uc001ezu.1	-	3	6174	c.6138C>T	c.(6136-6138)GAC>GAT	p.D2046D		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2046	Ser-rich.|Filaggrin 12.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCCTCACTGTCACTGGCCT	0.562									Ichthyosis				21	833					0	0	0	0	A	152281224	A	A	152281224	2	1	6	1	0	0	0	0	0	0	0	1	5954	1368	48	4		4	FLG	1	152281224	Silent	SNP	G	TCGA-BA-5149-01A-01D-1512-08	21	152281224	96969397	7	1648			1	2		2	2	22	G		9.700175e-05
NAV1	89796	broad.mit.edu	37	chr1	201751710	201751710	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaccggcgggcggggtggAcctcgccctgtgagcagcag	5	5	19	12	4	0	2	0	2	0	0	1	3	0	3	3	5	2	2	3	5	0	0			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr1:201751710A>T	uc001gwu.2	+	6	2417	c.2070A>T	c.(2068-2070)GGA>GGT	p.G690G	NAV1_uc001gwv.1_Silent_p.G198G|NAV1_uc001gww.1_Silent_p.G299G|NAV1_uc001gwx.2_Silent_p.G299G|NAV1_uc001gwy.1_Silent_p.G71G	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	690					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						GGCGGGGTGGACCTCGCCCTG	0.627													47	44					0	0	0	0	T	201751710	T	T	201751710	2	4	6	1	0	0	0	0	0	0	0	1	10236	262	10	5		5	NAV1	1	201751710	Silent	SNP	A	TCGA-BA-5149-01A-01D-1512-08	49470486	201751710	47498911	8	1649											
APOB	338	broad.mit.edu	37	chr2	21228715	21228715	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcatagactggtaggatGatatttttgaggaaccttag	11	15	11	4	0	1	3	1	2	0	1	1	5	1	5	1	3	1	1	1	3	5	7			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:21228715G>T	uc002red.2	-	26	11153	c.11025C>A	c.(11023-11025)ATC>ATA	p.I3675I		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3675					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTGGTAGGATGATATTTTTGA	0.458													58	87					1.17673e-23	1.42155e-23	1	0	T	21228715	T	T	21228715	2	4	6	1	0	0	0	0	0	0	0	1	785	1280	45	2		2	APOB	2	21228715	Silent	SNP	G	TCGA-BA-5149-01A-01D-1512-08		21228715	221970658	9	1650											
LTBP1	4052	broad.mit.edu	37	chr2	33500964	33500964	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atactgtgacagcgggtaccGcatgactcagagaggccgtt	10	8	13	10	3	1	3	1	2	0	1	1	4	1	3	2	2	3	3	2	2	2	3	rs142262862		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:33500964G>C	uc002ros.2	+	18	2969	c.2969G>C	c.(2968-2970)CGC>CCC	p.R990P	LTBP1_uc002rot.2_Missense_Mutation_p.R664P|LTBP1_uc002rou.2_Missense_Mutation_p.R663P|LTBP1_uc002rov.2_Missense_Mutation_p.R610P|LTBP1_uc010ymz.1_Missense_Mutation_p.R663P|LTBP1_uc010yna.1_Missense_Mutation_p.R610P	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	989	EGF-like 6; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AGCGGGTACCGCATGACTCAG	0.572													27	121					0	0	0	0	C	33500964	C	C	33500964	3	2	6	1	0	0	0	0	1	0	0	0	9123	1087	38	3	3091	3	LTBP1	2	33500964	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	12272249	33500964	209698409	10	1651											
SLC8A1	6546	broad.mit.edu	37	chr2	40657152	40657152	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagctatgatagagactccaAgaaacatgtagaccatggcc	15	7	9	10	0	0	4	0	1	0	3	1	5	1	4	3	1	2	2	3	1	5	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:40657152A>C	uc002rrx.2	-	1	293	c.269T>G	c.(268-270)CTT>CGT	p.L90R	SLC8A1_uc002rry.2_Missense_Mutation_p.L90R|SLC8A1_uc002rrz.2_Missense_Mutation_p.L90R|SLC8A1_uc002rsa.2_Missense_Mutation_p.L90R|SLC8A1_uc002rsd.3_Missense_Mutation_p.L90R|SLC8A1_uc002rsb.1_Missense_Mutation_p.L90R|SLC8A1_uc010fan.1_Missense_Mutation_p.L90R|SLC8A1_uc002rsc.1_Missense_Mutation_p.L90R	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	90	Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AGAGACTCCAAGAAACATGTA	0.423													88	115					0	0	0	0	C	40657152	C	C	40657152	3	2	6	1	0	0	0	0	1	0	0	0	14770	72	3	5	2800	5	SLC8A1	2	40657152	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	7156188	40657152	202542221	11	1652											
UBXN4	23190	broad.mit.edu	37	chr2	136499550	136499550	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccatcgcgacggccaaaagGagcggcgcggtcttcgtggt	7	6	16	12	7	1	0	0	0	1	0	3	2	1	1	2	5	1	0	2	5	2	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:136499550G>A	uc002tur.2	+	1	362	c.51G>A	c.(49-51)AGG>AGA	p.R17R		NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	17	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						CGGCCAAAAGGAGCGGCGCGG	0.672													6	22					0	0	0	0	A	136499550	A	A	136499550	2	1	6	1	0	0	0	0	0	0	0	1	16984	1165	41	2		2	UBXN4	2	136499550	Silent	SNP	G	TCGA-BA-5149-01A-01D-1512-08	95842398	136499550	106699823	12	1653											
GPD2	2820	broad.mit.edu	37	chr2	157426617	157426617	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtggcacagcatcttgccGccacctatggtgataaggcc	9	8	12	12	1	1	1	0	1	1	0	1	1	1	1	4	4	2	2	4	4	2	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:157426617G>C	uc002tzf.3	+	12	1855	c.1495G>C	c.(1495-1497)GCC>CCC	p.A499P	GPD2_uc010zch.1_Missense_Mutation_p.A272P|GPD2_uc002tzd.3_Missense_Mutation_p.A499P|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	499					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						GCATCTTGCCGCCACCTATGG	0.458													22	119					0	0	0	0	C	157426617	C	C	157426617	3	2	6	1	0	0	0	0	1	0	0	0	6644	1087	38	3	1537	3	GPD2	2	157426617	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	20927067	157426617	85772756	13	1654											
DPP4	1803	broad.mit.edu	37	chr2	162849867	162849867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttggtgtgctgtgctgctagCtattccatggtcttcatcag	5	16	11	9	0	3	0	2	0	1	0	4	0	4	0	1	2	4	4	1	2	2	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:162849867C>T	uc002ubz.2	-	26	2788	c.2227G>A	c.(2227-2229)GCT>ACT	p.A743T	DPP4_uc010fpb.2_Missense_Mutation_p.A419T	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	743	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	GTGCTGCTAGCTATTCCATGG	0.343													47	193					0	0	0	0	T	162849867	T	T	162849867	3	4	6	1	0	0	0	0	1	0	0	0	4751	797	28	4	77	4	DPP4	2	162849867	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	5423250	162849867	80349506	14	1655											
ZDBF2	57683	broad.mit.edu	37	chr2	207170711	207170711	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttagcctggttgaccaaagcTatgaatctagtagttctgaa	12	13	9	7	0	2	3	0	3	2	0	2	3	2	3	2	1	2	4	2	1	7	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:207170711T>G	uc002vbp.2	+	5	1709	c.1459T>G	c.(1459-1461)TAT>GAT	p.Y487D		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	487							nucleic acid binding|zinc ion binding			ovary(3)	3						TGACCAAAGCTATGAATCTAG	0.383													4	72					0	0	0	0	G	207170711	G	G	207170711	3	3	6	1	0	0	0	0	1	0	0	0	17666	1522	53	5	1469	5	ZDBF2	2	207170711	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	44320844	207170711	36028662	15	1656											
STK16	8576	broad.mit.edu	37	chr2	220113249	220113250	+	In_Frame_Ins	INS	-	CAG	CAG																															gctggaggcgcttcagccccINScagctcctggccaacatact																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:220113249_220113250insCAG	uc002vko.2	+	8	1043_1044	c.886_887insCAG	c.(886-888)CCA>CCAGCA	p.297_298insA	STK16_uc002vks.2_In_Frame_Ins_p.179_180insA|STK16_uc002vkp.2_In_Frame_Ins_p.297_298insA|STK16_uc002vkr.2_In_Frame_Ins_p.230_231insA|STK16_uc002vkq.2_In_Frame_Ins_p.342_343insA	NM_001008910	NP_001008910	O75716	STK16_HUMAN	serine/threonine kinase 16	297_298					protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTTCAGCCCCCAGCTCCTGGC	0.55													---	---	---								CAG	220113250	CAG	CAG	220113249	7	5	6	1	0	1	1	0	0	0	0	0	15355	623	22	0	912	0	STK16	2	220113249	In_Frame_Ins	INS	-	TCGA-BA-5149-01A-01D-1512-08	12942538	220113249	23086124	16	1657											
RBM44	375316	broad.mit.edu	37	chr2	238726675	238726675	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaagctttagagacattactCcaaccctgtaaagattgtca	15	11	6	9	0	1	2	1	0	0	2	2	3	2	2	2	0	3	2	2	0	6	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr2:238726675C>G	uc002vxi.3	+	3	1248	c.1116C>G	c.(1114-1116)CTC>CTG	p.L372L		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	371							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		AGACATTACTCCAACCCTGTA	0.353													34	110					0	0	0	0	G	238726675	G	G	238726675	2	3	6	1	0	0	0	0	0	0	0	1	13203	842	30	2		2	RBM44	2	238726675	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	18613426	238726675	4472698	17	1658											
SLC4A7	9497	broad.mit.edu	37	chr3	27490193	27490193	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atctgattctttatcttttcTtctccggtggtgatgtttgt	4	22	8	7	1	5	2	0	2	5	0	6	2	5	2	1	2	0	1	1	2	1	7			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:27490193T>A	uc003cdv.2	-	3	282	c.211A>T	c.(211-213)AGA>TGA	p.R71*	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Nonsense_Mutation_p.R76*|SLC4A7_uc011aww.1_Nonsense_Mutation_p.R80*|SLC4A7_uc011awx.1_Nonsense_Mutation_p.R80*|SLC4A7_uc011awy.1_Nonsense_Mutation_p.R76*|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Nonsense_Mutation_p.R76*|SLC4A7_uc011axb.1_Nonsense_Mutation_p.R80*|SLC4A7_uc010hfm.2_Nonsense_Mutation_p.R76*|SLC4A7_uc003cdw.2_Nonsense_Mutation_p.R71*	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	71	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						TTATCTTTTCTTCTCCGGTGG	0.408													78	71					0	0	0	0	A	27490193	A	A	27490193	4	1	6	1	0	0	0	0	0	1	0	0	14722	1617	56	5	3525	5	SLC4A7	3	27490193	Nonsense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08		27490193	170532237	18	1659											
ABHD5	51099	broad.mit.edu	37	chr3	43756504	43756504	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attcttcaatgttcgaagacGatactgtgacagaatacatc	14	12	7	8	2	2	3	1	1	1	2	4	5	2	3	0	0	2	1	0	0	5	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:43756504G>A	uc003cmx.2	+	5	837	c.727G>A	c.(727-729)GAT>AAT	p.D243N		NM_016006	NP_057090	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	243					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			ovary(1)	1		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		GTTCGAAGACGATACTGTGAC	0.318													31	101					0	0	0	0	A	43756504	A	A	43756504	3	1	6	1	0	0	0	0	1	0	0	0	85	1058	37	1	745	1	ABHD5	3	43756504	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	16266311	43756504	154265926	19	1660											
ZNF167	55888	broad.mit.edu	37	chr3	44612216	44612216	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctgttccaatagaaatctCattgaccatcagagaatcca	14	12	5	10	0	3	3	2	1	2	2	6	4	5	3	3	0	0	1	3	0	4	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:44612216C>G	uc010hin.2	+	6	2002	c.1614C>G	c.(1612-1614)CTC>CTG	p.L538L	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Silent_p.L538L|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	538	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		ATAGAAATCTCATTGACCATC	0.448													39	135					0	0	0	0	G	44612216	G	G	44612216	2	3	6	1	0	0	0	0	0	0	0	1	17808	813	29	2		2	ZNF167	3	44612216	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	855712	44612216	153410214	20	1661											
TREX1	11277	broad.mit.edu	37	chr3	48507992	48507993	+	Frame_Shift_Del	DEL	CT	-	-																															ctccccttcggatcttaacaCtgggcactcacacacccacc																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:48507992_48507993delCT	uc003ctj.2	+	2	1360_1361	c.103_104delCT	c.(103-105)CTGfs	p.L35fs	TREX1_uc010hjy.2_Intron|TREX1_uc003ctk.2_Intron|TREX1_uc010hjz.2_Intron|TREX1_uc010hka.2_Frame_Shift_Del_p.L35fs	NM_033629	NP_338599	Q9NSU2	TREX1_HUMAN	three prime repair exonuclease 1 isoform b	35					cell death|DNA recombination|DNA replication|mismatch repair	nuclear envelope	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|metal ion binding|MutLalpha complex binding|MutSalpha complex binding|protein homodimerization activity|single-stranded DNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GATCTTAACACTGGGCACTCAC	0.658								Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---								-	48507993	-	-	48507992	7	5	6	1	0	1	0	1	0	0	0	0	16543	564	20	0	105	0	TREX1	3	48507992	Frame_Shift_Del	DEL	CT	TCGA-BA-5149-01A-01D-1512-08	3895776	48507992	149514438	21	1662											
HESX1	8820	broad.mit.edu	37	chr3	57232884	57232884	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaaagtaattttcatatttcGaagctctttcttctggcatt	11	18	5	7	1	4	0	1	0	3	0	5	1	4	0	0	1	1	3	0	1	5	8	rs149663188		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:57232884G>A	uc003din.3	-	2	588	c.254C>T	c.(253-255)TCG>TTG	p.S85L		NM_003865	NP_003856	Q9UBX0	HESX1_HUMAN	HESX homeobox 1	85						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0109)|Kidney(284;0.0126)		TTCATATTTCGAAGCTCTTTC	0.418													128	367					0	0	0	0	A	57232884	A	A	57232884	3	1	6	1	0	0	0	0	1	0	0	0	7111	1059	37	1	315	1	HESX1	3	57232884	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	8724892	57232884	140789546	22	1663											
IFT57	55081	broad.mit.edu	37	chr3	107941068	107941068	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacatgtggtaggccgcgccGggcccccgctccaagaccac	8	4	12	17	4	0	1	0	0	0	1	1	1	1	1	6	3	1	2	6	3	3	1	rs150114125		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:107941068G>T	uc003dwx.3	-	1	350	c.102C>A	c.(100-102)CCC>CCA	p.P34P		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	34					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			AGGCCGCGCCGGGCCCCCGCT	0.637													21	43					3.83957e-06	4.24002e-06	1	0	T	107941068	T	T	107941068	2	4	6	1	0	0	0	0	0	0	0	1	7601	1103	39	3		3	IFT57	3	107941068	Silent	SNP	G	TCGA-BA-5149-01A-01D-1512-08	50708184	107941068	90081362	23	1664											
NR1I2	8856	broad.mit.edu	37	chr3	119533912	119533912	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attcaacacagtgttcaatgCggagactggaacctgggagt	12	9	12	8	1	2	1	2	0	0	1	2	4	2	3	1	3	3	1	1	3	3	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:119533912C>T	uc003edj.2	+	6	2720	c.881C>T	c.(880-882)GCG>GTG	p.A294V	NR1I2_uc003edi.2_Missense_Mutation_p.A257V|NR1I2_uc003edk.2_Missense_Mutation_p.A333V|NR1I2_uc003edl.2_Missense_Mutation_p.A182V	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	294	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	GTGTTCAATGCGGAGACTGGA	0.597													16	94					0	0	0	0	T	119533912	T	T	119533912	3	4	6	1	0	0	0	0	1	0	0	0	10674	768	27	1	1020	1	NR1I2	3	119533912	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	11592844	119533912	78488518	24	1665											
EEFSEC	60678	broad.mit.edu	37	chr3	128060189	128060189	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccctaagctgctggagcgCgggttggtgtgtgcccccga	5	8	16	12	3	0	0	0	0	0	0	0	3	0	1	3	3	4	3	3	3	1	2	rs114698998	byFrequency	TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:128060189C>T	uc003eki.2	+	5	938	c.900C>T	c.(898-900)CGC>CGT	p.R300R	EEFSEC_uc003ekj.2_Silent_p.R245R	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	300						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						TGCTGGAGCGCGGGTTGGTGT	0.592													42	99					0	0	0	0	T	128060189	T	T	128060189	2	4	6	1	0	0	0	0	0	0	0	1	4953	755	27	1		1	EEFSEC	3	128060189	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	8526277	128060189	69962241	25	1666											
COL6A6	131873	broad.mit.edu	37	chr3	130292957	130292957	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ataggagcggcccagtttagCgatacctatcacccggagtt	10	9	11	11	3	1	0	1	0	0	0	1	3	1	2	3	3	3	2	3	3	4	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:130292957C>T	uc010htl.2	+	7	3166	c.3135C>T	c.(3133-3135)AGC>AGT	p.S1045S		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1045	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CCCAGTTTAGCGATACCTATC	0.418													24	55					0	0	0	0	T	130292957	T	T	130292957	2	4	6	1	0	0	0	0	0	0	0	1	3718	767	27	1		1	COL6A6	3	130292957	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	2232768	130292957	67729473	26	1667											
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	17	7	10	7	0	1	2	1	2	0	0	1	4	1	3	0	3	3	2	0	3	5	0	rs121913279		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:178952085A>T	uc003fjk.2	+	21	3297	c.3140A>T	c.(3139-3141)CAT>CTT	p.H1047L		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			40	75					0	0	0	0	T	178952085	T	T	178952085	3	4	6	1	0	0	0	0	1	0	0	0	11968	217	8	5	3218	5	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	48659128	178952085	19070345	27	1668											
KLHL6	89857	broad.mit.edu	37	chr3	183210339	183210339	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gatgcatttagcctccacggGcatggccgccttcaaactcc	8	9	9	15	2	1	0	1	0	0	0	3	1	3	0	5	2	3	2	5	2	2	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:183210339G>A	uc003flr.2	-	6	1565	c.1507C>T	c.(1507-1509)CCC>TCC	p.P503S	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_3'UTR|KLHL6_uc010hxk.1_RNA	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	503	Kelch 4.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GCCTCCACGGGCATGGCCGCC	0.517													4	146					0	0	0	0	A	183210339	A	A	183210339	3	1	6	1	0	0	0	0	1	0	0	0	8432	1203	42	4	366	4	KLHL6	3	183210339	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	4258254	183210339	14812091	28	1669											
CRYGS	1427	broad.mit.edu	37	chr3	186257359	186257359	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagtcatagcgacggccttGaaaatttttgtcttcataga	12	13	8	8	2	3	2	2	1	1	1	3	3	3	2	1	1	1	0	1	1	4	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr3:186257359G>C	uc003fqe.2	-	2	101	c.49C>G	c.(49-51)CAA>GAA	p.Q17E	CRYGS_uc003fqf.2_Missense_Mutation_p.Q17E	NM_017541	NP_060011	P22914	CRBS_HUMAN	crystallin, gamma S	17	Beta/gamma crystallin 'Greek key' 1.						structural constituent of eye lens				0	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		CGACGGCCTTGAAAATTTTTG	0.433													23	99					0	0	0	0	C	186257359	C	C	186257359	3	2	6	1	0	0	0	0	1	0	0	0	3934	1299	45	2	495	2	CRYGS	3	186257359	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	3047020	186257359	11765071	29	1670											
CRMP1	1400	broad.mit.edu	37	chr4	5862807	5862807	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtcccttggaagaagtcatCagccgcagtcatcccctggg	8	8	12	13	1	3	1	3	0	0	1	5	2	5	2	4	3	1	1	4	3	2	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:5862807C>G	uc003gip.2	-	4	360	c.259G>C	c.(259-261)GAT>CAT	p.D87H	CRMP1_uc003gin.1_Intron|CRMP1_uc003giq.2_Missense_Mutation_p.D87H|CRMP1_uc003gir.2_Missense_Mutation_p.D82H|CRMP1_uc003gis.2_Missense_Mutation_p.D201H	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	87					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		AAGAAGTCATCAGCCGCAGTC	0.572													30	68					0	0	0	0	G	5862807	G	G	5862807	3	3	6	1	0	0	0	0	1	0	0	0	3905	826	29	2	1507	2	CRMP1	4	5862807	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08		5862807	185291469	30	1671											
UGDH	7358	broad.mit.edu	37	chr4	39523092	39523092	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacatgtgggtcctccaacaTagcctgcaccgatgcaacag	11	8	9	13	1	0	0	0	0	0	0	2	1	2	0	4	1	6	2	4	1	4	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:39523092T>C	uc003guk.1	-	2	357	c.41A>G	c.(40-42)TAT>TGT	p.Y14C	UGDH_uc011byp.1_Intron|UGDH_uc003gul.1_Missense_Mutation_p.Y14C	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	14	NAD.				glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	TCCTCCAACATAGCCTGCACC	0.373													28	97					0	0	0	0	C	39523092	C	C	39523092	3	2	6	1	0	0	0	0	1	0	0	0	17008	1406	49	5	1487	5	UGDH	4	39523092	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	33660285	39523092	151631184	31	1672											
GRXCR1	389207	broad.mit.edu	37	chr4	42965026	42965026	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agattttccaaaaccatcgcGtaaaatttgaagagaaaaac	19	9	6	7	2	0	3	0	1	0	2	2	4	1	3	2	0	2	1	2	0	7	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:42965026G>A	uc003gwt.2	+	2	502	c.502G>A	c.(502-504)GTA>ATA	p.V168I		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	168	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						AAACCATCGCGTAAAATTTGA	0.428													5	325					0	0	0	0	A	42965026	A	A	42965026	3	1	6	1	0	0	0	0	1	0	0	0	6851	1145	40	1	508	1	GRXCR1	4	42965026	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	3441934	42965026	148189250	32	1673											
PROL1	58503	broad.mit.edu	37	chr4	71275443	71275443	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tattcctttttttcttgctaTttaccttcctatctctaacc	6	22	1	12	0	2	0	0	0	2	0	5	0	4	0	4	0	3	1	4	0	5	12			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:71275443T>C	uc003hfi.2	+	3	572	c.398T>C	c.(397-399)ATT>ACT	p.I133T		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	133	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				TTTCTTGCTATTTACCTTCCT	0.443													56	210					0	0	0	0	C	71275443	C	C	71275443	3	2	6	1	0	0	0	0	1	0	0	0	12616	1493	52	5	404	5	PROL1	4	71275443	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	28310417	71275443	119878833	33	1674											
ANK2	287	broad.mit.edu	37	chr4	114294489	114294489	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcctctgaaggcacagagAaagaagagattatggtgcag	15	8	12	6	0	1	4	0	1	1	3	2	6	2	4	1	2	1	2	1	2	5	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:114294489A>C	uc003ibe.3	+	45	11843	c.11743A>C	c.(11743-11745)AAA>CAA	p.K3915Q	ANK2_uc003ibd.3_Missense_Mutation_p.K1821Q|ANK2_uc003ibf.3_Missense_Mutation_p.K1830Q|ANK2_uc011cgc.1_Missense_Mutation_p.K1006Q|ANK2_uc003ibg.3_Missense_Mutation_p.K845Q|ANK2_uc003ibh.3_Missense_Mutation_p.K535Q|ANK2_uc011cgd.1_Missense_Mutation_p.K1217Q|ANK2_uc010imr.2_5'UTR|ANK2_uc010ims.2_5'UTR	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3882					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGGCACAGAGAAAGAAGAGAT	0.403													57	88					0	0	0	0	C	114294489	C	C	114294489	3	2	6	1	0	0	0	0	1	0	0	0	621	247	9	5	11986	5	ANK2	4	114294489	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	43019046	114294489	76859787	34	1675											
TRAM1L1	133022	broad.mit.edu	37	chr4	118005580	118005580	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgaatattagaatcttctaCccacctctgaagccagagag	13	10	7	11	0	3	4	0	2	3	2	3	5	3	4	3	0	2	0	3	0	6	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:118005580C>A	uc003ibv.3	-	1	1157	c.970G>T	c.(970-972)GTA>TTA	p.V324L		NM_152402	NP_689615	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like	324	Cytoplasmic (Potential).|TLC.				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)	1						GAATCTTCTACCCACCTCTGA	0.408													135	198					1.85997e-60	2.26213e-60	1	0	A	118005580	A	A	118005580	3	1	6	1	0	0	0	0	1	0	0	0	16519	507	18	4	143	4	TRAM1L1	4	118005580	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	3711091	118005580	73148696	35	1676											
DCHS2	54798	broad.mit.edu	37	chr4	155156833	155156833	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgattgaaaagctgctggCgaacactgccaagggtgttc	10	9	13	9	1	0	2	0	2	0	0	1	3	0	2	1	2	4	4	1	2	4	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:155156833C>A	uc003inw.2	-	25	7606	c.7606G>T	c.(7606-7608)GCC>TCC	p.A2536S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2536					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AAGCTGCTGGCGAACACTGCC	0.393													16	94					1.02788e-11	1.17847e-11	1	0	A	155156833	A	A	155156833	3	1	6	1	0	0	0	0	1	0	0	0	4305	768	27	3	1148	3	DCHS2	4	155156833	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	37151253	155156833	35997443	36	1677											
TKTL2	84076	broad.mit.edu	37	chr4	164393537	164393537	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagatggcatcacttggataGaaaacagtacaattgggaat	16	9	11	5	0	1	2	1	0	0	2	1	5	1	4	0	3	2	2	0	3	6	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr4:164393537G>C	uc003iqp.3	-	1	1511	c.1350C>G	c.(1348-1350)TTC>TTG	p.F450L		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	450						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CACTTGGATAGAAAACAGTAC	0.488													39	131					0	0	0	0	C	164393537	C	C	164393537	3	2	6	1	0	0	0	0	1	0	0	0	16002	933	33	2	534	2	TKTL2	4	164393537	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	9236704	164393537	26760739	37	1678											
DNAH5	1767	broad.mit.edu	37	chr5	13721351	13721351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagtccacgatgtacttgcGggcctgccaaaaacagtata	12	8	11	10	2	0	0	0	0	0	0	1	2	1	1	3	2	4	2	3	2	5	4	rs148349630		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:13721351G>A	uc003jfd.2	-	71	12079	c.12037C>T	c.(12037-12039)CGC>TGC	p.R4013C	DNAH5_uc003jfc.2_Missense_Mutation_p.R181C	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4013	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATGTACTTGCGGGCCTGCCAA	0.328									Kartagener_syndrome				52	84					0	0	0	0	A	13721351	A	A	13721351	3	1	6	1	0	0	0	0	1	0	0	0	4626	1116	39	1	1873	1	DNAH5	5	13721351	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08		13721351	167193909	38	1679											
MAP3K1	4214	broad.mit.edu	37	chr5	56170929	56170929	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagagatggccctcaggcGtctttcccatgatgtcagtg	8	10	13	10	1	3	3	2	1	1	2	4	5	4	3	2	2	0	0	2	2	0	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:56170929G>A	uc003jqw.3	+	10	2258	c.1757G>A	c.(1756-1758)CGT>CAT	p.R586H		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	586					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GCCCTCAGGCGTCTTTCCCAT	0.527													48	277					0	0	0	0	A	56170929	A	A	56170929	3	1	6	1	0	0	0	0	1	0	0	0	9296	1145	40	1	1795	1	MAP3K1	5	56170929	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	42449578	56170929	124744331	39	1680											
HTR1A	3350	broad.mit.edu	37	chr5	63256858	63256858	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtcttctccacctttttgAccgtcttgcggatgcggaag	5	13	11	12	4	3	1	0	1	3	0	4	3	3	3	3	3	2	0	3	3	1	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:63256858A>G	uc011cqt.1	-	1	689	c.689T>C	c.(688-690)GTC>GCC	p.V230A		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	230	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CACCTTTTTGACCGTCTTGCG	0.587													4	99					0	0	0	0	G	63256858	G	G	63256858	3	3	6	1	0	0	0	0	1	0	0	0	7475	275	10	5	582	5	HTR1A	5	63256858	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	7085929	63256858	117658402	40	1681											
SLCO4C1	353189	broad.mit.edu	37	chr5	101606380	101606380	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatcatcaagaaaggctgtTcccagagtataaagaggagt	16	8	11	6	0	2	3	2	0	0	3	3	5	3	4	1	2	0	3	1	2	6	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:101606380T>A	uc003knm.2	-	3	1037	c.750A>T	c.(748-750)GGA>GGT	p.G250G		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	250	Helical; Name=4; (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GAAAGGCTGTTCCCAGAGTAT	0.388													9	104					0	0	0	0	A	101606380	A	A	101606380	2	1	6	1	0	0	0	0	0	0	0	1	14794	1770	62	5		5	SLCO4C1	5	101606380	Silent	SNP	T	TCGA-BA-5149-01A-01D-1512-08	38349522	101606380	79308880	41	1682											
DMXL1	1657	broad.mit.edu	37	chr5	118469800	118469800	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggagtttctgagcttgcccgGattaattctcttcatgtttc	6	17	9	9	1	3	1	1	1	2	0	5	3	3	3	1	2	2	3	1	2	1	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:118469800G>A	uc003ksd.2	+	12	2362	c.2181G>A	c.(2179-2181)CGG>CGA	p.R727R	DMXL1_uc010jcl.1_Silent_p.R727R|DMXL1_uc003ksc.1_Silent_p.R727R	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	727										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AGCTTGCCCGGATTAATTCTC	0.443													26	257					0	0	0	0	A	118469800	A	A	118469800	2	1	6	1	0	0	0	0	0	0	0	1	4616	1161	41	2		2	DMXL1	5	118469800	Silent	SNP	G	TCGA-BA-5149-01A-01D-1512-08	16863420	118469800	62445460	42	1683											
PRR16	51334	broad.mit.edu	37	chr5	120021755	120021755	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tagctcaagtggcacaacagCctccagcctagagaagatca	14	6	9	12	0	2	2	2	0	0	2	3	3	3	2	3	1	4	2	3	1	5	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:120021755C>A	uc003ksq.2	+	2	429	c.266C>A	c.(265-267)GCC>GAC	p.A89D	PRR16_uc003ksp.2_Missense_Mutation_p.A66D|PRR16_uc003ksr.2_Missense_Mutation_p.A19D	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	89										pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		GGCACAACAGCCTCCAGCCTA	0.527													42	75					2.66277e-13	3.09224e-13	1	0	A	120021755	A	A	120021755	3	1	6	1	0	0	0	0	1	0	0	0	12651	739	26	4	203	4	PRR16	5	120021755	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	1551955	120021755	60893505	43	1684											
NR3C1	2908	broad.mit.edu	37	chr5	142779539	142779539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctcttgcttaattaccccaGgggtgcagagttcgatgaaa	10	12	10	9	1	1	2	0	1	1	1	3	3	1	2	2	2	3	3	2	2	3	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:142779539G>A	uc003lmz.2	-	2	1358	c.866C>T	c.(865-867)CCT>CTT	p.P289L	NR3C1_uc003lmy.2_Missense_Mutation_p.P289L|NR3C1_uc003lna.2_Missense_Mutation_p.P289L|NR3C1_uc003lnb.2_Missense_Mutation_p.P289L|NR3C1_uc011dbk.1_Intron|NR3C1_uc003lnc.2_Missense_Mutation_p.P289L|NR3C1_uc003lnd.2_Missense_Mutation_p.P289L|NR3C1_uc003lne.2_Missense_Mutation_p.P289L|NR3C1_uc003lnf.2_Missense_Mutation_p.P289L|NR3C1_uc003lng.2_Missense_Mutation_p.P289L|NR3C1_uc003lnh.2_Missense_Mutation_p.P289L|NR3C1_uc003lni.2_Missense_Mutation_p.P289L	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	289	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	AATTACCCCAGGGGTGCAGAG	0.398													7	331					0	0	0	0	A	142779539	A	A	142779539	3	1	6	1	0	0	0	0	1	0	0	0	10684	1000	35	4	1554	4	NR3C1	5	142779539	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	22757784	142779539	38135721	44	1685											
FAT2	2196	broad.mit.edu	37	chr5	150925174	150925174	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcatggacatagacacaGaattggaaagagggcatgct	14	8	13	6	0	1	3	1	0	0	3	1	5	1	5	0	4	1	2	0	4	3	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:150925174G>T	uc003lue.3	-	9	5527	c.5514C>A	c.(5512-5514)TTC>TTA	p.F1838L	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1838	Extracellular (Potential).|Cadherin 16.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATAGACACAGAATTGGAAAG	0.463													27	135					1.39806e-14	1.65559e-14	1	0	T	150925174	T	T	150925174	3	4	6	1	0	0	0	0	1	0	0	0	5722	933	33	2	7595	2	FAT2	5	150925174	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	8145635	150925174	29990086	45	1686											
GABRP	2568	broad.mit.edu	37	chr5	170222219	170222219	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccccctcccaggactacaCagccaccatatacctccgac	10	6	4	21	1	0	0	0	0	0	0	3	2	3	1	7	1	3	0	7	1	3	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr5:170222219C>A	uc003mau.2	+	5	446	c.248C>A	c.(247-249)ACA>AAA	p.T83K	GABRP_uc011dev.1_Missense_Mutation_p.T83K	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	83	Extracellular (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGGACTACACAGCCACCATA	0.567													13	274					8.60227e-14	1.01203e-13	1	0	A	170222219	A	A	170222219	3	1	6	1	0	0	0	0	1	0	0	0	6208	478	17	4	262	4	GABRP	5	170222219	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	19297045	170222219	10693041	46	1687											
HIST1H2AA	221613	broad.mit.edu	37	chr6	25726458	25726458	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgggcaatggtcacgcCgcccaaaagcttattgagtt	9	9	11	12	2	1	1	1	1	0	0	1	1	1	1	3	2	1	3	3	2	4	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:25726458C>T	uc003nfc.2	-	1	333	c.298G>A	c.(298-300)GGC>AGC	p.G100S	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	100					nucleosome assembly	nucleosome|nucleus	DNA binding				0						ATGGTCACGCCGCCCAAAAGC	0.532													123	207					0	0	0	0	T	25726458	T	T	25726458	3	4	6	1	0	0	0	0	1	0	0	0	7167	652	23	1	101	1	HIST1H2AA	6	25726458	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08		25726458	145388609	47	1688											
TRIM27	5987	broad.mit.edu	37	chr6	28872383	28872383	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtaactgtaccgcacttgccGcagattatcagagaggatca	12	9	10	10	2	2	2	2	0	0	2	2	4	2	3	2	1	3	4	2	1	3	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:28872383G>A	uc003nlr.2	-	8	1365	c.1006C>T	c.(1006-1008)CGG>TGG	p.R336W	TRIM27_uc003nls.2_Missense_Mutation_p.R336W|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	336	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						CGCACTTGCCGCAGATTATCA	0.577			T	RET	papillary thyroid								9	53					0	0	0	0	A	28872383	A	A	28872383	3	1	6	1	0	0	0	0	1	0	0	0	16568	1086	38	1	539	1	TRIM27	6	28872383	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	3145925	28872383	142242684	48	1689											
TNXB	7148	broad.mit.edu	37	chr6	32038061	32038061	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcccgtctttgtccttgaaCtggaccacaaaagagtcgaa	11	9	10	11	2	1	2	0	1	1	1	3	4	2	3	3	2	1	0	3	2	4	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:32038061C>A	uc003nzl.2	-	14	5323	c.5121G>T	c.(5119-5121)CAG>CAT	p.Q1707H		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1789	Fibronectin type-III 10.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TGTCCTTGAACTGGACCACAA	0.637													10	23					0.000673444	0.000704767	1	0	A	32038061	A	A	32038061	3	1	6	1	0	0	0	0	1	0	0	0	16412	564	20	4	9716	4	TNXB	6	32038061	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	3165678	32038061	139077006	49	1690											
ATF6B	1388	broad.mit.edu	37	chr6	32093996	32093996	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggggtgccaaggactctgTcttcacatggagcacctccc	7	9	12	13	0	3	0	1	0	2	0	4	2	4	2	3	4	2	1	3	4	1	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:32093996T>A	uc003nzn.2	-	5	409	c.376A>T	c.(376-378)ACA>TCA	p.T126S	ATF6B_uc003nzo.2_Missense_Mutation_p.T123S|ATF6B_uc011dpg.1_Missense_Mutation_p.T60S|ATF6B_uc011dph.1_Missense_Mutation_p.T126S	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	126	Cytoplasmic (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AAGGACTCTGTCTTCACATGG	0.542													49	71					0	0	0	0	A	32093996	A	A	32093996	3	1	6	1	0	0	0	0	1	0	0	0	1087	1667	58	5	1791	5	ATF6B	6	32093996	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	55935	32093996	139021071	50	1691											
C6orf165	154313	broad.mit.edu	37	chr6	88138453	88138453	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagccattcttgggtgctcAcgaactatactttcctgaga	9	13	8	11	1	3	1	2	1	1	1	4	3	4	1	2	1	4	1	2	1	3	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:88138453A>G	uc003plv.2	+	9	1162	c.1070A>G	c.(1069-1071)CAC>CGC	p.H357R	C6orf165_uc003plw.2_Missense_Mutation_p.H169R|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Missense_Mutation_p.H357R	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	357										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TTGGGTGCTCACGAACTATAC	0.408													85	134					0	0	0	0	G	88138453	G	G	88138453	3	3	6	1	0	0	0	0	1	0	0	0	2351	159	6	5	1100	5	C6orf165	6	88138453	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	56044457	88138453	82976614	51	1692											
C6orf182	285753	broad.mit.edu	37	chr6	109484156	109484158	+	In_Frame_Del	DEL	ATC	-	-																															tgaaattgagaagagatgatAtcatgtgggaacagtaacaa																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:109484156_109484158delATC	uc010kdk.2	+	13	1943_1945	c.1366_1368delATC	c.(1366-1368)ATCdel	p.I456del	C6orf182_uc003psx.3_3'UTR|C6orf182_uc010kdl.2_In_Frame_Del_p.I456del|C6orf182_uc003psy.3_In_Frame_Del_p.I456del	NM_001083535	NP_001077004	Q8IYX8	CE57L_HUMAN	hypothetical protein LOC285753	456						microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)		AAGAGATGATATCATGTGGGAAC	0.335													---	---	---								-	109484158	-	-	109484156	7	5	6	1	0	1	0	1	0	0	0	0	2356	449	16	0	1404	0	C6orf182	6	109484156	In_Frame_Del	DEL	ATC	TCGA-BA-5149-01A-01D-1512-08	21345703	109484156	61630911	52	1693											
SLC16A10	117247	broad.mit.edu	37	chr6	111498518	111498518	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggacactatttcaagaagCgccttggactggtgaatggc	10	10	13	8	1	1	2	1	1	0	1	1	4	1	4	1	4	1	0	1	4	4	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:111498518C>T	uc003pus.2	+	3	767	c.592C>T	c.(592-594)CGC>TGC	p.R198C	SLC16A10_uc003pur.3_Missense_Mutation_p.R198C|SLC16A10_uc003put.2_5'UTR	NM_018593	NP_061063	Q8TF71	MOT10_HUMAN	solute carrier family 16, member 10	198	Extracellular (Potential).				aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity				0		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		TTTCAAGAAGCGCCTTGGACT	0.498													38	107					0	0	0	0	T	111498518	T	T	111498518	3	4	6	1	0	0	0	0	1	0	0	0	14468	768	27	1	602	1	SLC16A10	6	111498518	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	2014362	111498518	59616549	53	1694											
TXLNB	167838	broad.mit.edu	37	chr6	139568987	139568987	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttgaacgtggcaaacacCtcgttgcttttagttagtgt	8	16	10	7	2	0	1	0	1	0	0	1	1	0	1	1	1	3	5	1	1	4	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:139568987C>A	uc011eds.1	-	8	1302	c.1137G>T	c.(1135-1137)GAG>GAT	p.E379D		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	379	Potential.					cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TGGCAAACACCTCGTTGCTTT	0.383													4	180					0.00024832	0.000262927	1	0	A	139568987	A	A	139568987	3	1	6	1	0	0	0	0	1	0	0	0	16856	680	24	4	929	4	TXLNB	6	139568987	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	28070469	139568987	31546080	54	1695											
ARID1B	57492	broad.mit.edu	37	chr6	157528336	157528336	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggactgcctcgaggtcttgAgggataacacgttggtcacg	8	9	15	9	3	2	1	1	1	1	0	3	4	2	3	1	4	2	1	1	4	1	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:157528336A>G	uc003qqn.2	+	20	6159	c.6007A>G	c.(6007-6009)AGG>GGG	p.R2003G	ARID1B_uc003qqo.2_Missense_Mutation_p.R1963G|ARID1B_uc003qqp.2_Missense_Mutation_p.R1950G	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2008					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CGAGGTCTTGAGGGATAACAC	0.542													3	126					0	0	0	0	G	157528336	G	G	157528336	3	3	6	1	0	0	0	0	1	0	0	0	914	295	11	5	6139	5	ARID1B	6	157528336	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	17959349	157528336	13586731	55	1696											
FAM120B	84498	broad.mit.edu	37	chr6	170626814	170626814	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcaagaacaacagggagatAtccaggatttttcattacat	15	11	7	8	0	2	2	2	0	0	2	3	4	3	3	1	2	3	0	1	2	5	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr6:170626814A>G	uc003qxp.2	+	2	444	c.336A>G	c.(334-336)ATA>ATG	p.I112M	FAM120B_uc003qxo.1_Missense_Mutation_p.I112M|FAM120B_uc011ehd.1_Intron	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	112					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		ACAGGGAGATATCCAGGATTT	0.453													40	114					0	0	0	0	G	170626814	G	G	170626814	3	3	6	1	0	0	0	0	1	0	0	0	5445	439	16	5	338	5	FAM120B	6	170626814	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	13098478	170626814	488253	56	1697											
SDK1	221935	broad.mit.edu	37	chr7	4051785	4051785	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatatagtggccagtgggCggactaatcagtccattatg	13	10	11	7	1	1	0	1	0	0	0	2	1	2	1	2	3	0	0	2	3	6	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:4051785C>T	uc003smx.2	+	16	2477	c.2338C>T	c.(2338-2340)CGG>TGG	p.R780W	SDK1_uc010kso.2_Missense_Mutation_p.R56W	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	780	Fibronectin type-III 2.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGCCAGTGGGCGGACTAATCA	0.512													6	318					0	0	0	0	T	4051785	T	T	4051785	3	4	6	1	0	0	0	0	1	0	0	0	14033	759	27	1	2400	1	SDK1	7	4051785	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08		4051785	155086878	57	1698											
THSD7A	221981	broad.mit.edu	37	chr7	11418786	11418786	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacagcccgactggttttcAcatctcctcttttgtcctcc	5	15	6	15	1	3	0	1	0	2	0	6	1	5	0	4	1	2	2	4	1	1	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:11418786A>G	uc003ssf.3	-	25	4964	c.4712T>C	c.(4711-4713)GTG>GCG	p.V1571A	uc003ssb.2_Intron|THSD7A_uc003ssd.3_Missense_Mutation_p.V75A	NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1571	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ACTGGTTTTCACATCTCCTCT	0.522										HNSCC(18;0.044)			24	152					0	0	0	0	G	11418786	G	G	11418786	3	3	6	1	0	0	0	0	1	0	0	0	15945	159	6	5	273	5	THSD7A	7	11418786	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	7367001	11418786	147719877	58	1699											
TXNDC3	51314	broad.mit.edu	37	chr7	37927910	37927910	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agtttgcgatggacagtttgCcggtcaaccagttgtatggc	8	12	13	8	2	1	0	1	0	0	0	1	2	1	1	2	3	3	4	2	3	2	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:37927910C>T	uc003tfn.2	+	15	1651	c.1279C>T	c.(1279-1281)CCG>TCG	p.P427S		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	427	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						GGACAGTTTGCCGGTCAACCA	0.368									Kartagener_syndrome				4	180					0	0	0	0	T	37927910	T	T	37927910	3	4	6	1	0	0	0	0	1	0	0	0	16866	739	26	4	1329	4	TXNDC3	7	37927910	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	26509124	37927910	121210753	59	1700											
EPDR1	54749	broad.mit.edu	37	chr7	37989814	37989814	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttatagatgaaacctggaTtggcatctatacagtcaagg	13	12	9	7	0	3	2	1	1	2	1	3	3	3	3	1	3	2	1	1	3	6	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:37989814T>A	uc003tfp.2	+	3	870	c.851T>A	c.(850-852)ATT>AAT	p.I284N	EPDR1_uc003tfq.2_3'UTR|EPDR1_uc010kxh.2_Missense_Mutation_p.I103N	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	164					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						GAAACCTGGATTGGCATCTAT	0.318													11	109					0	0	0	0	A	37989814	A	A	37989814	3	1	6	1	0	0	0	0	1	0	0	0	5187	1493	52	5	861	5	EPDR1	7	37989814	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	61904	37989814	121148849	60	1701											
OGDH	4967	broad.mit.edu	37	chr7	44715617	44715617	+	Frame_Shift_Del	DEL	A	-	-																															gcatgtatcaccgcaggatcAatcgtgtcaccgacaggaac																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:44715617delA	uc003tln.2	+	9	1184	c.1075delA	c.(1075-1077)AATfs	p.N359fs	OGDH_uc003tlm.2_Frame_Shift_Del_p.N359fs|OGDH_uc011kbx.1_Frame_Shift_Del_p.N355fs|OGDH_uc011kby.1_Frame_Shift_Del_p.N209fs|OGDH_uc003tlp.2_Frame_Shift_Del_p.N370fs|OGDH_uc011kbz.1_Frame_Shift_Del_p.N154fs|OGDH_uc003tlo.1_Frame_Shift_Del_p.N192fs	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	359					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	CCGCAGGATCAATCGTGTCAC	0.562													---	---	---								-	44715617	-	-	44715617	7	5	6	1	0	1	0	1	0	0	0	0	10893	130	5	0	1200	0	OGDH	7	44715617	Frame_Shift_Del	DEL	A	TCGA-BA-5149-01A-01D-1512-08	6725803	44715617	114423046	61	1702											
ADCY1	107	broad.mit.edu	37	chr7	45750144	45750144	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggcatcaatgttggccctGtggtggctggagtgattggc	6	12	16	7	0	1	1	1	1	0	0	1	2	1	2	1	6	0	3	1	6	2	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:45750144G>T	uc003tne.3	+	19	2968	c.2950G>T	c.(2950-2952)GTG>TTG	p.V984L		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	984	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGTTGGCCCTGTGGTGGCTGG	0.582													18	101					1.10923e-09	1.24013e-09	1	0	T	45750144	T	T	45750144	3	4	6	1	0	0	0	0	1	0	0	0	292	1377	48	4	3024	4	ADCY1	7	45750144	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	1034527	45750144	113388519	62	1703											
IGFBP3	3486	broad.mit.edu	37	chr7	45956911	45956911	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggctgtctttagcatgcccTttcttgatgatgattatctt	6	19	8	8	0	3	3	0	3	3	0	3	3	3	3	1	1	2	2	1	1	2	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:45956911T>C	uc003tns.2	-	2	663	c.531A>G	c.(529-531)AAA>AAG	p.K177K	IGFBP3_uc003tnq.2_RNA|IGFBP3_uc003tnr.2_Silent_p.K183K|IGFBP3_uc003tnt.2_Silent_p.K80K	NM_000598	NP_000589	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	177					negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(2)|lung(1)	3					Mecasermin(DB01277)	TAGCATGCCCTTTCTTGATGA	0.547											OREG0018049	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	116	162					0	0	0	0	C	45956911	C	C	45956911	2	2	6	1	0	0	0	0	0	0	0	1	7619	1606	56	5		5	IGFBP3	7	45956911	Silent	SNP	T	TCGA-BA-5149-01A-01D-1512-08	206767	45956911	113181752	63	1704											
PCLO	27445	broad.mit.edu	37	chr7	82764455	82764455	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctgttggtggaaaactcTgtgagggtttggcagagtct	7	12	14	8	0	2	2	0	1	2	1	2	3	2	3	2	4	1	3	2	4	2	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:82764455T>G	uc003uhx.2	-	3	2700	c.2411A>C	c.(2410-2412)CAG>CCG	p.Q804P	PCLO_uc003uhv.2_Missense_Mutation_p.Q804P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	750	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGGAAAACTCTGTGAGGGTTT	0.433													80	185					0	0	0	0	G	82764455	G	G	82764455	3	3	6	1	0	0	0	0	1	0	0	0	11637	1580	55	5	13126	5	PCLO	7	82764455	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	36807544	82764455	76374208	64	1705											
GRM3	2913	broad.mit.edu	37	chr7	86415678	86415678	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgattactttgccaggacCgtgccccccgacttctacca	8	11	7	15	2	1	1	0	1	1	0	1	3	1	2	6	1	4	0	6	1	3	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:86415678C>T	uc003uid.2	+	3	1669	c.570C>T	c.(568-570)ACC>ACT	p.T190T	GRM3_uc010lef.2_Silent_p.T188T|GRM3_uc010leg.2_Silent_p.T62T|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	190	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TTGCCAGGACCGTGCCCCCCG	0.567													41	153					0	0	0	0	T	86415678	T	T	86415678	2	4	6	1	0	0	0	0	0	0	0	1	6837	639	23	1		1	GRM3	7	86415678	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	3651223	86415678	72722985	65	1706											
RELN	5649	broad.mit.edu	37	chr7	103252122	103252122	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcttcacctggttgtccAtgtgtggggtgtatttctgg	4	15	13	9	0	2	0	1	0	1	0	3	0	3	0	3	4	1	3	3	4	1	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:103252122A>T	uc003vca.2	-	21	2991	c.2831T>A	c.(2830-2832)ATG>AAG	p.M944K	RELN_uc010liz.2_Missense_Mutation_p.M944K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	944					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGGTTGTCCATGTGTGGGGT	0.463													32	46					0	0	0	0	T	103252122	T	T	103252122	3	4	6	1	0	0	0	0	1	0	0	0	13285	217	8	5	7731	5	RELN	7	103252122	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	16836444	103252122	55886541	66	1707											
GPR22	2845	broad.mit.edu	37	chr7	107115239	107115239	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taatattcgaataggcacaaGattttcaacagggcagaaga	17	9	9	6	1	1	3	1	0	0	3	2	4	1	3	0	2	1	2	0	2	7	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:107115239G>A	uc003vef.2	+	3	2080	c.734G>A	c.(733-735)AGA>AAA	p.R245K	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	245	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						ATAGGCACAAGATTTTCAACA	0.378													14	52					0	0	0	0	A	107115239	A	A	107115239	3	1	6	1	0	0	0	0	1	0	0	0	6720	942	33	2	736	2	GPR22	7	107115239	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	3863117	107115239	52023424	67	1708											
NOM1	64434	broad.mit.edu	37	chr7	156755792	156755792	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacgggtcgctggtggattGtggggtccgcctggagtggg	4	9	21	7	3	0	1	0	0	0	1	2	3	1	3	2	7	0	1	2	7	0	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr7:156755792G>T	uc003wmy.2	+	6	1849	c.1834G>T	c.(1834-1836)GTG>TTG	p.V612L	NOM1_uc010lqp.1_Missense_Mutation_p.V61L	NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	612					RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		CTGGTGGATTGTGGGGTCCGC	0.622													17	46					6.94344e-10	7.81137e-10	1	0	T	156755792	T	T	156755792	3	4	6	1	0	0	0	0	1	0	0	0	10584	1377	48	4	1856	4	NOM1	7	156755792	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	49640553	156755792	2382871	68	1709											
DOCK5	80005	broad.mit.edu	37	chr8	25166333	25166333	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctacatccgccagaggcagCtcatcatgtcgcctttgata	9	10	8	14	2	2	2	2	1	0	1	4	2	3	2	4	1	2	2	4	1	2	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:25166333C>G	uc003xeg.2	+	12	1221	c.1084C>G	c.(1084-1086)CTC>GTC	p.L362V	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.L76V|DOCK5_uc003xei.2_5'Flank	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	362						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CCAGAGGCAGCTCATCATGTC	0.468													27	26					0	0	0	0	G	25166333	G	G	25166333	3	3	6	1	0	0	0	0	1	0	0	0	4712	797	28	4	1130	4	DOCK5	8	25166333	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08		25166333	121197689	69	1710											
SLCO5A1	81796	broad.mit.edu	37	chr8	70591756	70591756	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgttctcattgagataagtCttgacaataaccacacggag	13	10	8	10	2	2	2	1	2	2	1	3	4	2	3	2	1	1	1	2	1	3	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:70591756C>G	uc003xyl.2	-	8	2588	c.1881G>C	c.(1879-1881)AAG>AAC	p.K627N	SLCO5A1_uc010lzb.2_Missense_Mutation_p.K572N|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.K627N	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	627	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TGAGATAAGTCTTGACAATAA	0.448													47	229					0	0	0	0	G	70591756	G	G	70591756	3	3	6	1	0	0	0	0	1	0	0	0	14795	912	32	2	677	2	SLCO5A1	8	70591756	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	45425423	70591756	75772266	70	1711											
KCNB2	9312	broad.mit.edu	37	chr8	73480489	73480489	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgataatacctgctgccctGataaaaggaagaaactgtgg	14	10	10	7	0	0	3	0	2	0	1	0	4	0	4	2	2	4	1	2	2	6	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:73480489G>C	uc003xzb.2	+	2	1108	c.520G>C	c.(520-522)GAT>CAT	p.D174H		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	174	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CTGCTGCCCTGATAAAAGGAA	0.438													37	212					0	0	0	0	C	73480489	C	C	73480489	3	2	6	1	0	0	0	0	1	0	0	0	8052	1290	45	2	522	2	KCNB2	8	73480489	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	2888733	73480489	72883533	71	1712											
FABP5	2171	broad.mit.edu	37	chr8	82195651	82195651	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caatggccaagccagattgtAtcatcacttgtgatggtaaa	13	11	9	8	0	2	2	2	1	0	1	2	2	2	2	2	2	1	2	2	2	5	4	rs145774881		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:82195651A>G	uc003yca.1	+	2	178	c.130A>G	c.(130-132)ATC>GTC	p.I44V		NM_001444	NP_001435	Q01469	FABP5_HUMAN	fatty acid binding protein 5	44					epidermis development	cytoplasm	fatty acid binding|protein binding|transporter activity				0	Lung NSC(7;3.57e-05)|all_lung(9;0.00011)		Epithelial(68;0.102)			GCCAGATTGTATCATCACTTG	0.393													9	93					0	0	0	0	G	82195651	G	G	82195651	3	3	6	1	0	0	0	0	1	0	0	0	5388	449	16	5	136	5	FABP5	8	82195651	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	8715162	82195651	64168371	72	1713											
KCNS2	3788	broad.mit.edu	37	chr8	99440425	99440425	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgggagttctacttcgaccGcaaccctgagctcttcccct	6	10	9	16	3	2	1	0	1	2	0	4	3	3	2	4	1	3	3	4	1	2	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:99440425G>A	uc003yin.2	+	2	568	c.218G>A	c.(217-219)CGC>CAC	p.R73H		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	73	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			TACTTCGACCGCAACCCTGAG	0.597													5	249					0	0	0	0	A	99440425	A	A	99440425	3	1	6	1	0	0	0	0	1	0	0	0	8128	1087	38	1	220	1	KCNS2	8	99440425	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	17244774	99440425	46923597	73	1714											
MTSS1	9788	broad.mit.edu	37	chr8	125577991	125577991	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtaatcagaacctttcaagtCcagaatcacctaaggggaca	15	8	8	10	0	3	2	3	0	0	2	4	3	4	3	3	2	1	1	3	2	5	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:125577991C>G	uc003yrk.2	-	9	1270	c.736G>C	c.(736-738)GAC>CAC	p.D246H	NDUFB9_uc011lim.1_Intron|MTSS1_uc011lin.1_5'UTR|MTSS1_uc011lio.1_Missense_Mutation_p.D136H|MTSS1_uc003yri.2_Missense_Mutation_p.D46H|MTSS1_uc003yrj.2_Missense_Mutation_p.D246H|MTSS1_uc003yrl.2_Missense_Mutation_p.D250H	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	246	IMD.|Ser-rich.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CCTTTCAAGTCCAGAATCACC	0.527													55	50					0	0	0	0	G	125577991	G	G	125577991	3	3	6	1	0	0	0	0	1	0	0	0	10015	855	30	2	1555	2	MTSS1	8	125577991	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	26137566	125577991	20786031	74	1715											
CYP11B2	1585	broad.mit.edu	37	chr8	143996592	143996592	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaccatcgggaggaacctCtgcacggccttgggcgacag	8	6	13	14	3	1	0	0	0	1	0	3	3	2	2	4	4	2	1	4	4	1	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr8:143996592C>G	uc003yxk.1	-	3	468	c.465G>C	c.(463-465)CAG>CAC	p.Q155H		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	155					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGAGGAACCTCTGCACGGCCT	0.637									Familial_Hyperaldosteronism_type_I				10	59					0	0	0	0	G	143996592	G	G	143996592	3	3	6	1	0	0	0	0	1	0	0	0	4163	912	32	2	1074	2	CYP11B2	8	143996592	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	18418601	143996592	2367430	75	1716											
TMEM38B	55151	broad.mit.edu	37	chr9	108483954	108483954	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagtcacacatgctaatagcTattacaaaaatggctggata	16	10	8	7	0	1	0	1	0	0	0	1	2	1	1	0	2	3	3	0	2	7	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr9:108483954T>A	uc004bcu.1	+	3	523	c.406T>A	c.(406-408)TAT>AAT	p.Y136N	TMEM38B_uc010mtn.1_Intron	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	136	Cytoplasmic (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2						TGCTAATAGCTATTACAAAAA	0.388													75	44					0	0	0	0	A	108483954	A	A	108483954	3	1	6	1	0	0	0	0	1	0	0	0	16226	1522	53	5	416	5	TMEM38B	9	108483954	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08		108483954	32729477	76	1717											
NOTCH1	4851	broad.mit.edu	37	chr9	139411734	139411740	+	Frame_Shift_Del	DEL	CTCGCAC	-	-																															tggccctcacccgtggggcaCtcgcactggaactcattgat																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr9:139411734_139411740delCTCGCAC	uc004chz.2	-	9	1539_1545	c.1539_1545delGTGCGAG	c.(1537-1545)CAGTGCGAGfs	p.Q513fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	513_515	Extracellular (Potential).|EGF-like 13; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCGTGGGGCACTCGCACTGGAACTCAT	0.691			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								-	139411740	-	-	139411734	7	5	6	1	0	1	0	1	0	0	0	0	10601	564	20	0	6226	0	NOTCH1	9	139411734	Frame_Shift_Del	DEL	CTCGCAC	TCGA-BA-5149-01A-01D-1512-08	30927780	139411734	1801697	77	1718											
CACNA1B	774	broad.mit.edu	37	chr9	140919617	140919617	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcttggggaagccacggtCgttcccagtgagtatctccc	6	10	11	14	2	2	1	0	1	2	0	5	2	3	2	4	3	1	2	4	3	2	3	rs147270326	by1000genomes	TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr9:140919617C>T	uc004cog.2	+	20	3424	c.3279C>T	c.(3277-3279)GTC>GTT	p.V1093V	CACNA1B_uc011mfd.1_Silent_p.V623V|CACNA1B_uc004coi.2_Silent_p.V303V	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1093	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AAGCCACGGTCGTTCCCAGTG	0.617													28	13					0	0	0	0	T	140919617	T	T	140919617	2	4	6	1	0	0	0	0	0	0	0	1	2551	871	31	1		1	CACNA1B	9	140919617	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	1507883	140919617	293814	78	1719											
SVIL	6840	broad.mit.edu	37	chr10	29821795	29821795	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgggctggtgcggagcttGagggggttgtgccacgtttt	4	12	19	6	2	0	1	0	1	0	0	0	2	0	2	1	5	3	4	1	5	0	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:29821795G>C	uc001iut.1	-	8	2254	c.1501C>G	c.(1501-1503)CAA>GAA	p.Q501E	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_Missense_Mutation_p.Q501E	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	501					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TGCGGAGCTTGAGGGGGTTGT	0.532													29	121					0	0	0	0	C	29821795	C	C	29821795	3	2	6	1	0	0	0	0	1	0	0	0	15487	1299	45	2	5267	2	SVIL	10	29821795	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08		29821795	105712952	79	1720											
NRG3	10718	broad.mit.edu	37	chr10	83635638	83635638	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catccgggccagcccgcgctCcaccacagcacggaacactg	9	3	10	19	4	0	0	0	0	0	0	2	1	2	1	5	2	3	2	5	2	1	0			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:83635638C>A	uc001kco.2	+	1	569	c.542C>A	c.(541-543)TCC>TAC	p.S181Y	NRG3_uc010qlz.1_Missense_Mutation_p.S181Y|NRG3_uc001kcp.2_5'Flank|NRG3_uc001kcq.2_5'Flank	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	181	Ser/Thr-rich.|Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AGCCCGCGCTCCACCACAGCA	0.721													10	34					3.86212e-05	4.18784e-05	1	0	A	83635638	A	A	83635638	3	1	6	1	0	0	0	0	1	0	0	0	10703	855	30	2	544	2	NRG3	10	83635638	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	53813843	83635638	51899109	80	1721											
MYOF	26509	broad.mit.edu	37	chr10	95111312	95111312	+	Nonsense_Mutation	SNP	A	T	T																															gagagaaaatgcttcgtcctAaaaattcatctttgccctag																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:95111312A>T	uc001kin.2	-	34	3803	c.3680T>A	c.(3679-3681)TTA>TAA	p.L1227*	MYOF_uc001kio.2_Nonsense_Mutation_p.L1214*|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1227	Cytoplasmic (Potential).|C2 4.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GCTTCGTCCTAAAAATTCATC	0.413													41	148					0	0	0	0	T	95111312	T	T	95111312	4	4	6	1	0	0	0	0	0	1	0	0	10142	372	13	5	2589	5	MYOF	10	95111312	Nonsense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	11475674	95111312	40423435	81	1722	5	2									
MYOF	26509	broad.mit.edu	37	chr10	95111315	95111315	+	Missense_Mutation	SNP	A	T	T																															agaaaatgcttcgtcctaaaAattcatctttgccctagaga																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:95111315A>T	uc001kin.2	-	34	3800	c.3677T>A	c.(3676-3678)TTT>TAT	p.F1226Y	MYOF_uc001kio.2_Missense_Mutation_p.F1213Y|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1226	Cytoplasmic (Potential).|C2 4.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						TCGTCCTAAAAATTCATCTTT	0.413													40	152					0	0	0	0	T	95111315	T	T	95111315	3	4	6	1	0	0	0	0	1	0	0	0	10142	14	1	5	2592	5	MYOF	10	95111315	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	3	95111315	40423432	82	1723	5	2									
COX15	1355	broad.mit.edu	37	chr10	101480789	101480789	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acctgctgttccatgagcaaAtcgtctcaactgtaggagtt	10	12	9	10	1	1	1	1	1	1	0	4	2	2	2	2	1	3	5	2	1	3	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:101480789A>G	uc001kqb.3	-	6	1404	c.787T>C	c.(787-789)TTT>CTT	p.F263L	COX15_uc001kqc.3_Missense_Mutation_p.F263L|COX15_uc010qpj.1_Missense_Mutation_p.F84L	NM_078470	NP_510870	Q7KZN9	COX15_HUMAN	COX15 homolog isoform 1	263					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		CCATGAGCAAATCGTCTCAAC	0.453													9	41					0	0	0	0	G	101480789	G	G	101480789	3	3	6	1	0	0	0	0	1	0	0	0	3779	101	4	5	531	5	COX15	10	101480789	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	6369474	101480789	34053958	83	1724											
FAM160B1	57700	broad.mit.edu	37	chr10	116605950	116605950	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagttctgagatgggtattCtcacatccactgctctgctt	7	15	8	11	0	4	1	2	1	3	1	6	2	5	1	1	1	2	4	1	1	1	4	rs17853717		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:116605950C>T	uc001lcb.2	+	10	1557	c.1222C>T	c.(1222-1224)CTC>TTC	p.L408F	FAM160B1_uc001lcc.2_Missense_Mutation_p.L408F	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	408										lung(1)	1						GATGGGTATTCTCACATCCAC	0.433													7	420					0	0	0	0	T	116605950	T	T	116605950	3	4	6	1	0	0	0	0	1	0	0	0	5498	913	32	2	1260	2	FAM160B1	10	116605950	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	15125161	116605950	18928797	84	1725											
ATRNL1	26033	broad.mit.edu	37	chr10	117061476	117061476	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggtgcagcagtacgaaacGatgtgttgactctaatgcct	10	11	12	8	2	1	1	0	1	1	0	1	3	1	1	1	1	5	4	1	1	3	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:117061476G>A	uc001lcg.2	+	17	3127	c.2741G>A	c.(2740-2742)CGA>CAA	p.R914Q	ATRNL1_uc010qsm.1_Missense_Mutation_p.R89Q|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	914	PSI 4.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGTACGAAACGATGTGTTGAC	0.453													29	163					0	0	0	0	A	117061476	A	A	117061476	3	1	6	1	0	0	0	0	1	0	0	0	1209	1058	37	1	2807	1	ATRNL1	10	117061476	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	455526	117061476	18473271	85	1726											
ADAM8	101	broad.mit.edu	37	chr10	135083954	135083954	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcacacatccacgatgcaGatggcacgccccaggggctg	9	5	13	14	2	0	1	0	0	0	1	1	2	1	1	3	4	1	4	3	4	0	0			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr10:135083954G>C	uc010qva.1	-	15	1629	c.1578C>G	c.(1576-1578)ATC>ATG	p.I526M	ADAM8_uc010quz.1_Missense_Mutation_p.I565M|ADAM8_uc009ybi.2_Missense_Mutation_p.I565M			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	526					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		CCACGATGCAGATGGCACGCC	0.652													19	65					0	0	0	0	C	135083954	C	C	135083954	3	2	6	1	0	0	0	0	1	0	0	0	252	932	33	2	729	2	ADAM8	10	135083954	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	18022478	135083954	450793	86	1727											
EPS8L2	64787	broad.mit.edu	37	chr11	720157	720157	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgagctccaaggagaagatCtggacccaggagatgctgct	11	7	13	10	0	1	4	0	1	1	3	2	7	2	5	2	3	3	3	2	3	2	0			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:720157C>G	uc001lqt.2	+	5	508	c.261C>G	c.(259-261)ATC>ATG	p.I87M	EPS8L2_uc010qwj.1_Missense_Mutation_p.I87M|EPS8L2_uc001lqu.2_Missense_Mutation_p.I87M|EPS8L2_uc010qwk.1_Missense_Mutation_p.I87M|EPS8L2_uc001lqv.2_Missense_Mutation_p.I42M|EPS8L2_uc001lqw.2_5'Flank|EPS8L2_uc001lqx.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	87	PID.					cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGGAGAAGATCTGGACCCAGG	0.627													9	38					0	0	0	0	G	720157	G	G	720157	3	3	6	1	0	0	0	0	1	0	0	0	5220	903	32	2	275	2	EPS8L2	11	720157	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08		720157	134286359	87	1728											
RHOG	391	broad.mit.edu	37	chr11	3848803	3848803	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgccagggtcacaagaggAtgcaggaccgcccacgcttg	10	5	14	12	2	1	1	1	0	0	1	1	3	1	3	3	3	2	2	3	3	1	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:3848803A>C	uc001lyu.2	-	2	724	c.566T>G	c.(565-567)ATC>AGC	p.I189S		NM_001665	NP_001656	P84095	RHOG_HUMAN	ras homolog gene family, member G precursor	189					actin cytoskeleton organization|activation of Rac GTPase activity|axon guidance|cell chemotaxis|platelet activation|positive regulation of cell proliferation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of transcription, DNA-dependent|Rac protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0349)|LUSC - Lung squamous cell carcinoma(625;0.194)		TCACAAGAGGATGCAGGACCG	0.627													7	30					0	0	0	0	C	3848803	C	C	3848803	3	2	6	1	0	0	0	0	1	0	0	0	13404	333	12	5	13	5	RHOG	11	3848803	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	3128646	3848803	131157713	88	1729											
C11orf41	25758	broad.mit.edu	37	chr11	33565011	33565017	+	Frame_Shift_Del	DEL	CACCCAG	-	-																															tccatactctccatacaagcCacccagactgttttcccatc																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:33565011_33565017delCACCCAG	uc001mup.3	+	1	1135_1141	c.1011_1017delCACCCAG	c.(1009-1017)GCCACCCAGfs	p.A337fs	C11orf41_uc001mun.1_Frame_Shift_Del_p.A337fs	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	337_339						integral to membrane				ovary(2)	2						CCATACAAGCCACCCAGACTGTTTTCC	0.517											OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	33565017	-	-	33565011	7	5	6	1	0	1	0	1	0	0	0	0	1646	581	21	0	1013	0	C11orf41	11	33565011	Frame_Shift_Del	DEL	CACCCAG	TCGA-BA-5149-01A-01D-1512-08	29716208	33565011	101441505	89	1730											
FAM111B	374393	broad.mit.edu	37	chr11	58892771	58892771	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaatgaagccataatgcatCagtatccgaattttaaagag	16	11	8	6	1	1	3	1	2	0	1	2	4	2	3	2	0	2	2	2	0	7	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:58892771C>G	uc001nnl.2	+	4	1444	c.1201C>G	c.(1201-1203)CAG>GAG	p.Q401E	FAM111B_uc001nnm.2_Missense_Mutation_p.Q371E|FAM111B_uc010rko.1_Missense_Mutation_p.Q371E	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	401							catalytic activity			ovary(2)	2						CATAATGCATCAGTATCCGAA	0.378													48	113					0	0	0	0	G	58892771	G	G	58892771	3	3	6	1	0	0	0	0	1	0	0	0	5428	827	29	2	1207	2	FAM111B	11	58892771	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	25327760	58892771	76113745	90	1731											
DAGLA	747	broad.mit.edu	37	chr11	61503242	61503242	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacctgacgggtgatgctgAgcgcctccccgtggaggggc	5	7	17	12	3	0	4	0	4	0	0	1	5	1	5	4	4	2	1	4	4	0	0			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:61503242A>T	uc001nsa.2	+	12	1355	c.1244A>T	c.(1243-1245)GAG>GTG	p.E415V		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	415	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GGTGATGCTGAGCGCCTCCCC	0.672													6	13					0	0	0	0	T	61503242	T	T	61503242	3	4	6	1	0	0	0	0	1	0	0	0	4243	304	11	5	1286	5	DAGLA	11	61503242	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	2610471	61503242	73503274	91	1732											
FAT3	120114	broad.mit.edu	37	chr11	92531604	92531605	+	Missense_Mutation	DNP	GC	AA	AA																															atgctgacagcaaccggaatGctctgcttgtgtatcagatt																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr11:92531604_92531605GC>AA	uc001pdj.3	+	9	5442_5443	c.5425_5426GC>AA	c.(5425-5427)GCT>AAT	p.A1809N		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1809	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAACCGGAATGCTCTGCTTGTG	0.485										TCGA Ovarian(4;0.039)			5	20					0	0	0	0	AA	92531605	AA	AA	92531604	3	1	6	1	0	0	0	0	1	0	0	0	5723	1319	46	4	5459	4	FAT3	11	92531604	Missense_Mutation	DNP	GC	TCGA-BA-5149-01A-01D-1512-08	31028362	92531604	42474912	92	1733											
A2M	2	broad.mit.edu	37	chr12	9222346	9222346	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaagttctcttaccttatCaaggtaaatcaagacatggt	13	13	8	7	0	3	1	2	0	1	1	4	2	3	2	1	3	1	2	1	3	7	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:9222346C>T	uc001qvk.1	-	33	4371	c.4258G>A	c.(4258-4260)GAT>AAT	p.D1420N	A2M_uc001qvj.1_Missense_Mutation_p.D462N|A2M_uc009zgk.1_Missense_Mutation_p.D1270N	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1420					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CTTACCTTATCAAGGTAAATC	0.353													40	160					0	0	0	0	T	9222346	T	T	9222346	3	4	6	1	0	0	0	0	1	0	0	0	4	826	29	2	182	2	A2M	12	9222346	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08		9222346	124629549	93	1734											
ADCY6	112	broad.mit.edu	37	chr12	49176910	49176910	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcgggcgccacctcagccGtcccgcccgctgtcgttgtc	2	8	12	19	7	1	0	1	0	0	0	5	0	2	0	5	1	1	2	5	1	0	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:49176910G>A	uc001rsh.3	-	1	968	c.308C>T	c.(307-309)ACG>ATG	p.T103M	ADCY6_uc001rsj.3_Missense_Mutation_p.T103M|ADCY6_uc001rsi.3_Missense_Mutation_p.T103M	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	103	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CACCTCAGCCGTCCCGCCCGC	0.697													16	59					0	0	0	0	A	49176910	A	A	49176910	3	1	6	1	0	0	0	0	1	0	0	0	298	1145	40	1	3282	1	ADCY6	12	49176910	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	39954564	49176910	84674985	94	1735											
MLL2	8085	broad.mit.edu	37	chr12	49434105	49434105	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagcgaagtgtgggctagaGacccagccttaaaggcaact	12	6	12	11	1	0	1	0	0	0	1	0	3	0	1	3	2	3	2	3	2	5	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:49434105G>C	uc001rta.3	-	31	7448	c.7448C>G	c.(7447-7449)TCT>TGT	p.S2483C		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2483	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTGGGCTAGAGACCCAGCCTT	0.667			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			8	67					0	0	0	0	C	49434105	C	C	49434105	3	2	6	1	0	0	0	0	1	0	0	0	9674	942	33	2	9261	2	MLL2	12	49434105	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	257195	49434105	84417790	95	1736											
MYF5	4617	broad.mit.edu	37	chr12	81111152	81111152	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaaggtcaaccaggctttcGaaaccctcaagaggtgtacc	13	7	10	11	1	2	2	2	0	0	2	3	3	2	2	3	3	3	2	3	3	5	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:81111152G>A	uc001szg.2	+	1	445	c.310G>A	c.(310-312)GAA>AAA	p.E104K		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	104	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CCAGGCTTTCGAAACCCTCAA	0.597													25	77					0	0	0	0	A	81111152	A	A	81111152	3	1	6	1	0	0	0	0	1	0	0	0	10080	1059	37	1	312	1	MYF5	12	81111152	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	31677047	81111152	52740743	96	1737											
PPFIA2	8499	broad.mit.edu	37	chr12	81693145	81693145	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatccctttctccgagcttCttcaagaagttcatgcctga	9	14	6	12	1	4	2	2	1	2	1	6	3	5	2	3	0	2	2	3	0	3	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:81693145C>A	uc001szo.1	-	23	2820	c.2659G>T	c.(2659-2661)GAA>TAA	p.E887*	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	813										ovary(3)|lung(2)|pancreas(1)	6						CTCCGAGCTTCTTCAAGAAGT	0.378													3	13					0.004672	0.0048331	1	0	A	81693145	A	A	81693145	4	1	6	1	0	0	0	0	0	1	0	0	12365	922	32	2	1154	2	PPFIA2	12	81693145	Nonsense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	581993	81693145	52158750	97	1738											
ATP2B1	490	broad.mit.edu	37	chr12	89995159	89995159	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaccatagccactgttctaTtgaaagttctgaacaactga	13	12	7	9	0	2	4	0	4	2	0	2	4	2	4	2	0	3	2	2	0	5	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:89995159T>A	uc001tbh.2	-	18	3293	c.3112A>T	c.(3112-3114)ATA>TTA	p.I1038L	ATP2B1_uc001tbg.2_Missense_Mutation_p.I1038L|ATP2B1_uc009zsr.2_5'Flank|ATP2B1_uc001tbf.2_Intron	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	1038	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						CACTGTTCTATTGAAAGTTCT	0.299													60	196					0	0	0	0	A	89995159	A	A	89995159	3	1	6	1	0	0	0	0	1	0	0	0	1141	1493	52	5	720	5	ATP2B1	12	89995159	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	8302014	89995159	43856736	98	1739											
PRKAB1	5564	broad.mit.edu	37	chr12	120111774	120111774	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctttttccttgcagccacaAtaactttgtagccatcctgg	8	14	6	13	0	0	0	0	0	0	0	2	0	2	0	5	1	4	2	5	1	3	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:120111774A>G	uc009zwu.2	+	4	432	c.329A>G	c.(328-330)AAT>AGT	p.N110S	PRKAB1_uc001txg.2_Missense_Mutation_p.N110S	NM_006253	NP_006244	Q9Y478	AAKB1_HUMAN	AMP-activated protein kinase beta 1	110					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol					0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	TGCAGCCACAATAACTTTGTA	0.522													33	113					0	0	0	0	G	120111774	G	G	120111774	3	3	6	1	0	0	0	0	1	0	0	0	12557	101	4	5	339	5	PRKAB1	12	120111774	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	30116615	120111774	13740121	99	1740											
CAMKK2	10645	broad.mit.edu	37	chr12	121686456	121686456	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gactgagttctcgacctcctCttcagtcacttcgaccagcg	7	11	8	15	3	4	1	2	1	2	0	7	4	5	1	3	0	1	1	3	0	0	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr12:121686456C>G	uc001tzu.2	-	14	1529	c.1405G>C	c.(1405-1407)GAG>CAG	p.E469Q	CAMKK2_uc001tzt.2_Missense_Mutation_p.E469Q|CAMKK2_uc001tzv.2_Missense_Mutation_p.E469Q|CAMKK2_uc001tzw.2_Intron|CAMKK2_uc001tzx.2_Missense_Mutation_p.E469Q|CAMKK2_uc001tzy.2_Intron|CAMKK2_uc001tzz.1_Missense_Mutation_p.E256Q|CAMKK2_uc001uaa.1_Missense_Mutation_p.E469Q|CAMKK2_uc001uab.2_Missense_Mutation_p.E469Q|CAMKK2_uc001uac.2_Intron	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase	469					calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCGACCTCCTCTTCAGTCACT	0.612													34	204					0	0	0	0	G	121686456	G	G	121686456	3	3	6	1	0	0	0	0	1	0	0	0	2619	922	32	2	387	2	CAMKK2	12	121686456	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	1574682	121686456	12165439	100	1741											
MTUS2	23281	broad.mit.edu	37	chr13	29599467	29599467	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agcacggggtcagatacctgGgggtggggaggggccacaga	9	4	20	8	1	1	2	1	0	0	2	1	3	1	3	2	8	2	1	2	8	1	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr13:29599467G>T	uc001usl.3	+	1	720	c.662G>T	c.(661-663)GGG>GTG	p.G221V		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	211						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						CAGATACCTGGGGGTGGGGAG	0.607													9	34					6.40141e-05	6.89972e-05	1	0	T	29599467	T	T	29599467	3	4	6	1	0	0	0	0	1	0	0	0	10019	1232	43	4	664	4	MTUS2	13	29599467	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08		29599467	85570411	101	1742											
TRPC4	7223	broad.mit.edu	37	chr13	38320380	38320380	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccaaggccttgtagatgttGagtctggagcgtgagtgacg	8	10	16	7	2	1	4	0	3	1	1	1	5	1	5	2	2	1	2	2	2	2	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr13:38320380G>C	uc001uws.2	-	3	826	c.591C>G	c.(589-591)CTC>CTG	p.L197L	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Silent_p.L197L|TRPC4_uc010tey.1_Silent_p.L197L|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Silent_p.L197L|TRPC4_uc010aby.2_Silent_p.L197L	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	197	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TGTAGATGTTGAGTCTGGAGC	0.527													26	76					0	0	0	0	C	38320380	C	C	38320380	2	2	6	1	0	0	0	0	0	0	0	1	16647	1277	45	2		2	TRPC4	13	38320380	Silent	SNP	G	TCGA-BA-5149-01A-01D-1512-08	8720913	38320380	76849498	102	1743											
SLAIN1	122060	broad.mit.edu	37	chr13	78320898	78320898	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgtaggaggagccccagttCccagtattttccttcaaata	10	12	9	10	0	1	0	1	0	0	0	3	2	3	2	4	2	1	3	4	2	4	7			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr13:78320898C>T	uc010thy.1	+	4	717	c.674C>T	c.(673-675)TCC>TTC	p.S225F	SLAIN1_uc001vkk.1_Missense_Mutation_p.S148F|SLAIN1_uc001vkl.1_Missense_Mutation_p.S104F|SLAIN1_uc010thz.1_Missense_Mutation_p.S103F|SLAIN1_uc010aex.1_Intron|SLAIN1_uc010aey.1_Intron|SLAIN1_uc001vkm.2_Missense_Mutation_p.S104F	NM_144595	NP_653196	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1 B	367										ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)		AGCCCCAGTTCCCAGTATTTT	0.478													54	97					0	0	0	0	T	78320898	T	T	78320898	3	4	6	1	0	0	0	0	1	0	0	0	14430	855	30	2	453	2	SLAIN1	13	78320898	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	40000518	78320898	36848980	103	1744											
OR4N2	390429	broad.mit.edu	37	chr14	20296147	20296147	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggacaacttcttctgtgaTgtcccacaggtcatcaagct	9	12	8	12	0	4	1	2	1	2	0	5	2	5	2	1	2	2	1	1	2	2	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:20296147T>A	uc010tkv.1	+	1	540	c.540T>A	c.(538-540)GAT>GAA	p.D180E		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTCTGTGATGTCCCACAGG	0.542													84	135					0	0	0	0	A	20296147	A	A	20296147	3	1	6	1	0	0	0	0	1	0	0	0	11131	1461	51	5	542	5	OR4N2	14	20296147	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08		20296147	87053393	104	1745											
HOMEZ	57594	broad.mit.edu	37	chr14	23746104	23746104	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttcagatgaccagctaatAccacagcggaggcgctgggc	10	7	12	12	2	2	2	1	1	1	1	2	3	2	3	2	3	3	2	2	3	2	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:23746104A>G	uc001wja.2	-	2	481	c.333T>C	c.(331-333)GGT>GGC	p.G111G	HOMEZ_uc001wjb.2_Silent_p.G113G	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	111	Homeobox 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		ACCAGCTAATACCACAGCGGA	0.498													6	244					0	0	0	0	G	23746104	G	G	23746104	2	3	6	1	0	0	0	0	0	0	0	1	7320	378	14	5		5	HOMEZ	14	23746104	Silent	SNP	A	TCGA-BA-5149-01A-01D-1512-08	3449957	23746104	83603436	105	1746											
RBM25	58517	broad.mit.edu	37	chr14	73566382	73566382	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgttttcttttaggaggataTaaatgctatagaaatggaag	14	14	10	3	1	1	1	0	0	1	1	1	4	1	4	0	3	1	2	0	3	8	8			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:73566382T>G	uc001xno.2	+	9	999	c.791T>G	c.(790-792)ATA>AGA	p.I264R	RBM25_uc001xnn.3_Missense_Mutation_p.I264R|RBM25_uc010ttu.1_Missense_Mutation_p.I264R|RBM25_uc001xnp.2_Missense_Mutation_p.I59R	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	264					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		TAGGAGGATATAAATGCTATA	0.358													22	156					0	0	0	0	G	73566382	G	G	73566382	3	3	6	1	0	0	0	0	1	0	0	0	13190	1406	49	5	821	5	RBM25	14	73566382	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	49820278	73566382	33783158	106	1747											
HEATR4	399671	broad.mit.edu	37	chr14	73973233	73973234	+	Nonsense_Mutation	DNP	GA	TT	TT																															cacaatccggttcttccattGacagctgttcagctccacag																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:73973233_73973234GA>TT	uc010tub.1	-	10	2245_2246	c.1923_1924TC>AA	c.(1921-1926)TGTCAA>TGAAAA	p.641_642CQ>*K	HEATR4_uc010tua.1_Nonsense_Mutation_p.594_595CQ>*K	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TTCTTCCATTGACAGCTGTTCA	0.465													33	169					0	0	0	0	TT	73973234	TT	TT	73973233	4	4	6	1	0	0	0	0	0	1	0	0	7069	1299	45	2	1192	2	HEATR4	14	73973233	Nonsense_Mutation	DNP	GA	TCGA-BA-5149-01A-01D-1512-08	406851	73973233	33376307	107	1748											
NEK9	91754	broad.mit.edu	37	chr14	75562095	75562095	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttccaatggataagccaCtgctattggaacggatggtc	11	10	11	9	1	0	0	0	0	0	0	2	3	1	3	2	4	3	2	2	4	4	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:75562095C>T	uc001xrl.2	-	18	2367	c.2213G>A	c.(2212-2214)AGT>AAT	p.S738N	NEK9_uc001xrk.2_Missense_Mutation_p.S238N	NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	738	Interaction with NEK6.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)		GGATAAGCCACTGCTATTGGA	0.388													7	105					0	0	0	0	T	75562095	T	T	75562095	3	4	6	1	0	0	0	0	1	0	0	0	10385	565	20	4	746	4	NEK9	14	75562095	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	1588862	75562095	31787445	108	1749											
CYP46A1	10858	broad.mit.edu	37	chr14	100187605	100187605	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgaggtggatgaggtcattgGttctaagaggtacctggatt	9	12	15	5	1	2	2	1	1	1	1	2	5	2	4	1	6	1	2	1	6	2	5			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr14:100187605G>A	uc001ygo.2	+	11	1010	c.1010G>A	c.(1009-1011)GGT>GAT	p.G337D	CYP46A1_uc001ygp.2_Missense_Mutation_p.G184D	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	337					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GAGGTCATTGGTTCTAAGAGG	0.547													16	75					0	0	0	0	A	100187605	A	A	100187605	3	1	6	1	0	0	0	0	1	0	0	0	4199	1261	44	4	1052	4	CYP46A1	14	100187605	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	24625510	100187605	7161935	109	1750											
MAPKBP1	23005	broad.mit.edu	37	chr15	42113097	42113097	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggacccagaagaagagggcGctgggttcagccaggtgtgg	10	5	18	8	1	1	3	1	0	0	3	1	4	1	4	2	5	1	2	2	5	2	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr15:42113097G>A	uc001zok.3	+	24	2853	c.2567G>A	c.(2566-2568)CGC>CAC	p.R856H	MAPKBP1_uc001zoj.3_Missense_Mutation_p.R850H|MAPKBP1_uc010bcj.2_Missense_Mutation_p.R357H|MAPKBP1_uc010bci.2_Missense_Mutation_p.R850H|MAPKBP1_uc010udb.1_Missense_Mutation_p.R689H|MAPKBP1_uc010bck.2_Missense_Mutation_p.R67H|MAPKBP1_uc010bcl.2_Missense_Mutation_p.R357H	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	856										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		AGAAGAGGGCGCTGGGTTCAG	0.637													13	52					0	0	0	0	A	42113097	A	A	42113097	3	1	6	1	0	0	0	0	1	0	0	0	9345	1087	38	1	2657	1	MAPKBP1	15	42113097	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08		42113097	60418295	110	1751											
C15orf33	196951	broad.mit.edu	37	chr15	49882141	49882141	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaatgaactatcttcttttaTttttttcagagtgcatgacc	11	18	5	7	0	3	3	1	2	2	1	3	3	3	3	1	0	2	1	1	0	4	7			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr15:49882141T>C	uc001zxl.2	-	4	463	c.169A>G	c.(169-171)ATA>GTA	p.I57V	C15orf33_uc001zxm.2_Missense_Mutation_p.I57V	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	57				I -> M (in Ref. 1; BAB71451).						ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		TCTTCTTTTATTTTTTTCAGA	0.318													26	129					0	0	0	0	C	49882141	C	C	49882141	3	2	6	1	0	0	0	0	1	0	0	0	1797	1493	52	5	1409	5	C15orf33	15	49882141	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	7769044	49882141	52649251	111	1752											
CILP	8483	broad.mit.edu	37	chr15	65494259	65494259	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcacagccccagcatcactCtgggccttgcaaaagtactc	10	9	7	15	0	3	0	2	0	1	0	4	0	3	0	3	1	4	3	3	1	3	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr15:65494259C>G	uc002aon.2	-	8	1318	c.1137G>C	c.(1135-1137)CAG>CAC	p.Q379H		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	379	Ig-like C2-type.				negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CAGCATCACTCTGGGCCTTGC	0.572													11	46					0	0	0	0	G	65494259	G	G	65494259	3	3	6	1	0	0	0	0	1	0	0	0	3444	912	32	2	2425	2	CILP	15	65494259	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	15612118	65494259	37037133	112	1753											
SEPT12	124404	broad.mit.edu	37	chr16	4835848	4835848	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtccccgaagccgggcgtgtCcgtcaccgtcagcttcagct	5	8	12	16	5	3	0	3	0	0	0	5	1	5	0	5	1	3	2	5	1	1	1	rs141666105		TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:4835848C>G	uc002cxq.2	-	4	475	c.334G>C	c.(334-336)GAC>CAC	p.D112H	SEPT12_uc002cxr.2_Missense_Mutation_p.D112H|SEPT12_uc010bty.2_RNA|uc002cxt.2_5'Flank	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	112					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity	p.D112N(1)		skin(1)	1						CCGGGCGTGTCCGTCACCGTC	0.363													24	88					0	0	0	0	G	4835848	G	G	4835848	3	3	6	1	0	0	0	0	1	0	0	0	14127	855	30	2	770	2	SEPT12	16	4835848	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08		4835848	85518905	113	1754											
SMG1	23049	broad.mit.edu	37	chr16	18852958	18852958	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaataagggtgtggctccatCtacccactggattagtcctg	10	11	10	10	0	1	0	0	0	1	0	3	1	3	1	3	3	1	1	3	3	4	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:18852958C>A	uc002dfm.2	-	41	6988	c.6625G>T	c.(6625-6627)GAT>TAT	p.D2209Y	SMG1_uc010bwb.2_Missense_Mutation_p.D2069Y|SMG1_uc010bwa.2_Missense_Mutation_p.D940Y|SMG1_uc002dfo.3_Missense_Mutation_p.D507Y	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2209	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						GTGGCTCCATCTACCCACTGG	0.433													47	171					4.01344e-20	4.81612e-20	1	0	A	18852958	A	A	18852958	3	1	6	1	0	0	0	0	1	0	0	0	14859	913	32	2	4452	2	SMG1	16	18852958	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	14017110	18852958	71501795	114	1755											
CETP	1071	broad.mit.edu	37	chr16	56996954	56996954	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccaaggtgatccagaccGccttccagcgagccagctac	9	6	10	16	2	0	2	0	1	0	1	2	3	2	2	6	1	5	1	6	1	2	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:56996954G>T	uc002eki.2	+	2	208	c.151G>T	c.(151-153)GCC>TCC	p.A51S	CETP_uc002ekj.2_Missense_Mutation_p.A51S	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	51					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						GATCCAGACCGCCTTCCAGCG	0.622													12	67					1.36491e-13	1.59535e-13	1	0	T	56996954	T	T	56996954	3	4	6	1	0	0	0	0	1	0	0	0	3292	1087	38	3	157	3	CETP	16	56996954	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	38143996	56996954	33357799	115	1756											
ZFPM1	161882	broad.mit.edu	37	chr16	88598565	88598565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagagacctaccccaacgagCgcgtctgccccttcccccag	9	5	8	19	3	1	1	0	0	1	1	2	3	2	1	7	0	4	0	7	0	3	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:88598565C>T	uc002fkv.2	+	7	901	c.868C>T	c.(868-870)CGC>TGC	p.R290C		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	290	C2H2-type 1.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CCCCAACGAGCGCGTCTGCCC	0.716													7	46					0	0	0	0	T	88598565	T	T	88598565	3	4	6	1	0	0	0	0	1	0	0	0	17724	768	27	1	894	1	ZFPM1	16	88598565	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	31601611	88598565	1756188	116	1757											
CDH15	1013	broad.mit.edu	37	chr16	89254553	89254553	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcggagtggatgtgggaCgcctggaagtggaggacagg	9	6	20	6	2	1	0	1	0	0	0	1	6	1	6	1	7	1	0	1	7	1	0			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:89254553C>T	uc002fmt.2	+	7	915	c.838C>T	c.(838-840)CGC>TGC	p.R280C		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	280	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGATGTGGGACGCCTGGAAGT	0.647													4	40					0	0	0	0	T	89254553	T	T	89254553	3	4	6	1	0	0	0	0	1	0	0	0	3115	536	19	1	864	1	CDH15	16	89254553	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	655988	89254553	1100200	117	1758											
ANKRD11	29123	broad.mit.edu	37	chr16	89351208	89351208	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attccacactggagccctcaGaggagtagtcagactcgctt	10	9	10	12	1	2	2	2	0	0	2	4	4	3	4	2	2	1	2	2	2	1	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr16:89351208G>C	uc002fmx.1	-	9	2203	c.1742C>G	c.(1741-1743)TCT>TGT	p.S581C	ANKRD11_uc002fmy.1_Missense_Mutation_p.S581C|ANKRD11_uc002fnc.1_Missense_Mutation_p.S581C|ANKRD11_uc002fnb.1_Missense_Mutation_p.S538C	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	581	Ser-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GGAGCCCTCAGAGGAGTAGTC	0.547													12	69					0	0	0	0	C	89351208	C	C	89351208	3	2	6	1	0	0	0	0	1	0	0	0	639	942	33	2	6269	2	ANKRD11	16	89351208	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	96655	89351208	1003545	118	1759											
GAS7	8522	broad.mit.edu	37	chr17	9820581	9820581	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagggcggatgttgcccgtCttgtgctctctgacccacag	6	10	12	13	2	2	1	0	1	2	0	3	2	2	2	2	2	2	2	2	2	0	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr17:9820581C>G	uc002gmg.1	-	14	1556	c.1395G>C	c.(1393-1395)AAG>AAC	p.K465N	GAS7_uc010vvc.1_Missense_Mutation_p.K279N|GAS7_uc002gmh.1_Missense_Mutation_p.K325N|GAS7_uc010vvd.1_Missense_Mutation_p.K417N|GAS7_uc002gmi.2_Missense_Mutation_p.K401N|GAS7_uc002gmj.1_Missense_Mutation_p.K405N|GAS7_uc010coh.1_Missense_Mutation_p.K405N	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	465					cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						TGTTGCCCGTCTTGTGCTCTC	0.627			T	MLL	AML*								17	68					0	0	0	0	G	9820581	G	G	9820581	3	3	6	1	0	0	0	0	1	0	0	0	6285	912	32	2	39	2	GAS7	17	9820581	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08		9820581	71374629	119	1760											
TMIGD1	388364	broad.mit.edu	37	chr17	28645840	28645840	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttagataccttcattattttCtttcttctagcaatcagtcc	9	19	3	10	0	5	1	2	0	3	1	6	1	6	1	2	0	2	1	2	0	5	9			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr17:28645840C>T	uc002hfa.1	-	5	805	c.732G>A	c.(730-732)AAG>AAA	p.K244K	TMIGD1_uc010csh.1_Intron	NM_206832	NP_996663	Q6UXZ0	TMIG1_HUMAN	transmembrane and immunoglobulin domain	244	Cytoplasmic (Potential).					integral to membrane					0						TCATTATTTTCTTTCTTCTAG	0.353													28	104					0	0	0	0	T	28645840	T	T	28645840	2	4	6	1	0	0	0	0	0	0	0	1	16296	912	32	2		2	TMIGD1	17	28645840	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	18825259	28645840	52549370	120	1761											
ACCN1	40	broad.mit.edu	37	chr17	32483260	32483260	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtggtgagcctggagaaccGgaagccattcaggttacaga	11	7	15	8	1	1	3	1	1	0	2	1	5	1	4	3	5	4	1	3	5	3	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr17:32483260G>A	uc002hhu.2	-	1	566	c.292C>T	c.(292-294)CGG>TGG	p.R98W		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	98	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	CTGGAGAACCGGAAGCCATTC	0.582													15	46					0	0	0	0	A	32483260	A	A	32483260	3	1	6	1	0	0	0	0	1	0	0	0	128	1115	39	1	1998	1	ACCN1	17	32483260	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	3837420	32483260	48711950	121	1762											
FAM134C	162427	broad.mit.edu	37	chr17	40761276	40761276	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaggagcctgacacatctcGgcggcccctgaaagtcgacc	9	5	11	16	3	1	2	0	2	1	0	3	4	1	3	5	3	1	0	5	3	1	0			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr17:40761276G>A	uc002ial.2	-	1	170	c.67C>T	c.(67-69)CGA>TGA	p.R23*	TUBG1_uc002ian.2_5'Flank|FAM134C_uc010wgq.1_5'UTR|FAM134C_uc002iam.1_5'UTR|FAM134C_uc010cyk.1_Intron	NM_178126	NP_835227	Q86VR2	F134C_HUMAN	hypothetical protein LOC162427	23						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		GACACATCTCGGCGGCCCCTG	0.711													29	20					0	0	0	0	A	40761276	A	A	40761276	4	1	6	1	0	0	0	0	0	1	0	0	5475	1124	39	1	1369	1	FAM134C	17	40761276	Nonsense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	8278016	40761276	40433934	122	1763											
RGS9	8787	broad.mit.edu	37	chr17	63156694	63156694	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcagtggccagctgaagAtaccgattacggtaaatact	13	8	10	10	2	0	2	0	1	0	1	0	3	0	2	3	2	5	3	3	2	6	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr17:63156694A>G	uc002jfe.2	+	5	463	c.353A>G	c.(352-354)GAT>GGT	p.D118G	RGS9_uc010dem.2_Missense_Mutation_p.D118G|RGS9_uc002jfd.2_Missense_Mutation_p.D118G|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	118					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						CCAGCTGAAGATACCGATTAC	0.463													12	60					0	0	0	0	G	63156694	G	G	63156694	3	3	6	1	0	0	0	0	1	0	0	0	13378	333	12	5	371	5	RGS9	17	63156694	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08	22395418	63156694	18038516	123	1764											
MC2R	4158	broad.mit.edu	37	chr18	13885247	13885247	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actgccacgtggcttgagatAgcccatgtttctcaatatga	10	12	9	10	1	1	2	1	2	1	1	2	3	1	2	2	1	2	2	2	1	3	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr18:13885247A>T	uc002ksp.1	-	2	448	c.271T>A	c.(271-273)TAT>AAT	p.Y91N		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	91	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	GGCTTGAGATAGCCCATGTTT	0.458													20	105					0	0	0	0	T	13885247	T	T	13885247	3	4	6	1	0	0	0	0	1	0	0	0	9417	420	15	5	626	5	MC2R	18	13885247	Missense_Mutation	SNP	A	TCGA-BA-5149-01A-01D-1512-08		13885247	64192001	124	1765											
FBXO15	201456	broad.mit.edu	37	chr18	71797721	71797721	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttgagaatgtcagctagtgCggcttttacagatgctattt	9	16	10	6	1	1	2	1	1	0	2	1	3	1	2	0	1	4	3	0	1	4	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr18:71797721C>T	uc002lle.2	-	4	613	c.277G>A	c.(277-279)GCA>ACA	p.A93T	FBXO15_uc002llf.2_Missense_Mutation_p.A169T	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	93										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		TCAGCTAGTGCGGCTTTTACA	0.418													3	83					0	0	0	0	T	71797721	T	T	71797721	3	4	6	1	0	0	0	0	1	0	0	0	5760	768	27	1	1055	1	FBXO15	18	71797721	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	57912474	71797721	6279527	125	1766											
ARRDC2	27106	broad.mit.edu	37	chr19	18121139	18121139	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agcttcctgctggactggagGctgggggccttgccggagcg	4	8	18	11	2	0	0	0	0	0	0	1	3	1	3	3	6	4	3	3	6	0	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr19:18121139G>T	uc002nhv.2	+	6	1127	c.984G>T	c.(982-984)AGG>AGT	p.R328S	ARRDC2_uc002nhu.2_Missense_Mutation_p.R323S	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2 isoform 1	328										pancreas(1)	1						TGGACTGGAGGCTGGGGGCCT	0.647													12	33					4.7546e-09	5.28289e-09	1	0	T	18121139	T	T	18121139	3	4	6	1	0	0	0	0	1	0	0	0	985	1194	42	4	1269	4	ARRDC2	19	18121139	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08		18121139	41007844	126	1767											
GPI	2821	broad.mit.edu	37	chr19	34859497	34859497	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaatccccagggtcgagccGtgctgcacgtggctctgcgg	5	8	15	13	4	1	0	0	0	1	0	3	1	2	0	3	3	4	4	3	3	1	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr19:34859497G>T	uc002nvg.1	+	4	395	c.292G>T	c.(292-294)GTG>TTG	p.V98L	GPI_uc002nvf.2_Missense_Mutation_p.V137L|GPI_uc010xrv.1_Missense_Mutation_p.V137L|GPI_uc010xrw.1_Missense_Mutation_p.V98L|GPI_uc010edl.1_Missense_Mutation_p.V98L|GPI_uc002nvh.1_3'UTR	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	98					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					GGGTCGAGCCGTGCTGCACGT	0.597													8	71					1.12685e-05	1.22929e-05	1	0	T	34859497	T	T	34859497	3	4	6	1	0	0	0	0	1	0	0	0	6649	1145	40	3	427	3	GPI	19	34859497	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	16738358	34859497	24269486	127	1768											
FFAR3	2865	broad.mit.edu	37	chr19	35850648	35850648	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcctccgggttccaagccGactttcatgagctgctgagg	6	10	11	14	2	1	2	1	2	0	0	4	3	4	2	5	2	3	3	5	2	1	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr19:35850648G>A	uc002nzd.2	+	2	931	c.856G>A	c.(856-858)GAC>AAC	p.D286N	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	286	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			GTTCCAAGCCGACTTTCATGA	0.597													12	92					0	0	0	0	A	35850648	A	A	35850648	3	1	6	1	0	0	0	0	1	0	0	0	5861	1058	37	1	858	1	FFAR3	19	35850648	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08	991151	35850648	23278335	128	1769											
ZNF567	163081	broad.mit.edu	37	chr19	37210997	37210997	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagtgaatgtggaaagtcCttccgccagaagacaaccct	12	9	10	10	1	0	3	0	1	0	2	2	4	2	4	4	1	1	1	4	1	5	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr19:37210997C>A	uc010xtl.1	+	6	1593	c.1371C>A	c.(1369-1371)TCC>TCA	p.S457S	ZNF567_uc002oeo.1_Silent_p.S457S|ZNF567_uc010xtk.1_Silent_p.S457S|ZNF567_uc002oep.3_Silent_p.S426S|ZNF567_uc002oeq.1_Silent_p.S426S	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	457	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GTGGAAAGTCCTTCCGCCAGA	0.428													38	73					3.3946e-10	3.86727e-10	1	0	A	37210997	A	A	37210997	2	1	6	1	0	0	0	0	0	0	0	1	18065	668	24	4		4	ZNF567	19	37210997	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	1360349	37210997	21917986	129	1770											
MARK4	57787	broad.mit.edu	37	chr19	45768123	45768123	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtttgactacctcgtgtcGcatggccgcatgaaggagaa	9	10	13	9	3	0	3	0	2	0	1	2	4	0	3	2	2	1	3	2	2	3	2			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr19:45768123G>A	uc002pbb.1	+	6	452	c.447G>A	c.(445-447)TCG>TCA	p.S149S	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Silent_p.S149S|MARK4_uc002pbc.1_Silent_p.S15S			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	149	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ACCTCGTGTCGCATGGCCGCA	0.677													13	147					0	0	0	0	A	45768123	A	A	45768123	2	1	6	1	0	0	0	0	0	0	0	1	9368	1074	38	1		1	MARK4	19	45768123	Silent	SNP	G	TCGA-BA-5149-01A-01D-1512-08	8557126	45768123	13360860	130	1771											
ZNF337	26152	broad.mit.edu	37	chr20	25656794	25656794	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttgcttacactgcctgcacGcaaagggcttctcccctgag	7	11	9	14	1	1	1	0	1	1	0	2	1	1	1	3	1	4	4	3	1	2	3			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr20:25656794G>A	uc002wva.2	-	4	1652	c.1130C>T	c.(1129-1131)GCG>GTG	p.A377V	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Missense_Mutation_p.A345V|ZNF337_uc002wvb.2_Missense_Mutation_p.A377V|ZNF337_uc002wvc.2_Missense_Mutation_p.A377V	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	377	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTGCCTGCACGCAAAGGGCTT	0.512													25	130					0	0	0	0	A	25656794	A	A	25656794	3	1	6	1	0	0	0	0	1	0	0	0	17920	1087	38	1	1129	1	ZNF337	20	25656794	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08		25656794	37368726	131	1772											
CBFA2T2	9139	broad.mit.edu	37	chr20	32212735	32212735	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacctcttcagcattacacCttagaggatattgcaacttc	11	12	5	13	0	2	1	1	0	1	1	3	2	2	2	3	1	4	2	3	1	4	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr20:32212735C>T	uc002wzg.1	+	7	1422	c.885C>T	c.(883-885)ACC>ACT	p.T295T	CBFA2T2_uc010zug.1_Silent_p.T69T|CBFA2T2_uc002wze.1_Silent_p.T286T|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Silent_p.T266T|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	295						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						AGCATTACACCTTAGAGGATA	0.532													45	80					0	0	0	0	T	32212735	T	T	32212735	2	4	6	1	0	0	0	0	0	0	0	1	2709	668	24	4		4	CBFA2T2	20	32212735	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	6555941	32212735	30812785	132	1773											
RBL1	5933	broad.mit.edu	37	chr20	35717398	35717398	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaaagaggtttaccttaatTtagctgaacgtagtattctg	12	15	8	6	1	2	2	1	1	1	1	2	2	2	2	1	1	3	4	1	1	7	8			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr20:35717398T>G	uc002xgi.2	-	2	363	c.284A>C	c.(283-285)AAA>ACA	p.K95T	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.K95T|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	95					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				TTACCTTAATTTAGCTGAACG	0.323													65	106					0	0	0	0	G	35717398	G	G	35717398	3	3	6	1	0	0	0	0	1	0	0	0	13174	1841	64	5	3015	5	RBL1	20	35717398	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	3504663	35717398	27308122	133	1774											
RALGAPB	57148	broad.mit.edu	37	chr20	37144953	37144953	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtatccctgccttaaacatCtgcctcaaatattttttcgt	10	16	4	11	1	2	0	1	0	1	0	4	0	3	0	3	0	3	1	3	0	5	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr20:37144953C>T	uc002xiw.2	+	7	1248	c.991C>T	c.(991-993)CTG>TTG	p.L331L	RALGAPB_uc010zvz.1_Silent_p.L331L|RALGAPB_uc002xix.2_Silent_p.L331L|RALGAPB_uc002xiy.1_Silent_p.L331L|RALGAPB_uc002xiz.2_Silent_p.L109L|RALGAPB_uc002xja.1_Silent_p.L58L	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	331					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						CCTTAAACATCTGCCTCAAAT	0.413													54	419					0	0	0	0	T	37144953	T	T	37144953	2	4	6	1	0	0	0	0	0	0	0	1	13080	912	32	2		2	RALGAPB	20	37144953	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	1427555	37144953	25880567	134	1775											
TP53RK	112858	broad.mit.edu	37	chr20	45315819	45315819	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccttcaatttcttccataTataagcagttggaagcatag	13	13	7	8	0	2	0	1	0	1	0	3	1	3	1	2	1	3	3	2	1	6	8			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr20:45315819T>C	uc002xsk.2	-	2	558	c.335A>G	c.(334-336)TAT>TGT	p.Y112C	SLC13A3_uc002xsg.1_5'Flank|SLC13A3_uc010gho.1_5'Flank|TP53RK_uc002xsj.2_Missense_Mutation_p.I114V	NM_033550	NP_291028	Q96S44	PRPK_HUMAN	p53-related protein kinase	112	Protein kinase.				lipopolysaccharide biosynthetic process	membrane|nucleus	ATP binding|p53 binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Myeloproliferative disorder(115;0.0122)				TTCTTCCATATATAAGCAGTT	0.403													108	477					0	0	0	0	C	45315819	C	C	45315819	3	2	6	1	0	0	0	0	1	0	0	0	16457	1406	49	5	430	5	TP53RK	20	45315819	Missense_Mutation	SNP	T	TCGA-BA-5149-01A-01D-1512-08	8170866	45315819	17709701	135	1776											
TPTE	7179	broad.mit.edu	37	chr21	11014973	11014973	+	RNA	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattgcagaataagatcttcTtctctatagtttcaatagca	13	15	5	8	0	4	2	1	0	3	2	5	2	4	2	0	0	2	3	0	0	6	8			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr21:11014973T>C	uc002yis.1	-	7		c.1473A>G						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAAGATCTTCTTCTCTATAGT	0.353													10	35					0	0	0	0	C	11014973	C	C	11014973	1	2	6	0	1	0	0	0	0	0	0	0	16497	1624	56	5		5	TPTE	21	11014973	RNA	SNP	T	TCGA-BA-5149-01A-01D-1512-08		11014973	37114922	136	1777											
RUNX1	861	broad.mit.edu	37	chr21	36206846	36206846	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccagttcactgagccgctcGgaaaaggacaagctcccggg	10	6	12	13	3	1	1	1	1	0	0	4	3	3	3	3	3	2	3	3	3	3	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr21:36206846G>A	uc002yuh.2	-	4	2163	c.585C>T	c.(583-585)TCC>TCT	p.S195S	RUNX1_uc002yui.2_Intron|RUNX1_uc010gmu.2_Silent_p.S222S|RUNX1_uc010gmv.2_Silent_p.S222S|RUNX1_uc002yuj.3_Silent_p.S90S|RUNX1_uc002yuk.3_Silent_p.S222S|RUNX1_uc002yul.1_5'UTR|RUNX1_uc002yum.1_Intron|RUNX1_uc010gmw.1_Silent_p.S222S|RUNX1_uc002yuo.1_Silent_p.S195S	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	195	Pro/Ser/Thr-rich.			Missing: No DNA-binding.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.I195fs*19(1)		haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						TGAGCCGCTCGGAAAAGGACA	0.517			T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				25	126					0	0	0	0	A	36206846	A	A	36206846	2	1	6	1	0	0	0	0	0	0	0	1	13811	1103	39	1		1	RUNX1	21	36206846	Silent	SNP	G	TCGA-BA-5149-01A-01D-1512-08	25191873	36206846	11923049	137	1778											
TNRC6B	23112	broad.mit.edu	37	chr22	40719213	40719213	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctcctttactacctggtGaccttctgggaggagggtcg	5	12	13	11	1	1	1	0	1	1	0	3	3	2	3	3	4	3	1	3	4	2	4			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr22:40719213G>A	uc011aor.1	+	23	5681	c.5470G>A	c.(5470-5472)GAC>AAC	p.D1824N	TNRC6B_uc003aym.2_Missense_Mutation_p.D1020N|TNRC6B_uc003ayn.3_Missense_Mutation_p.D1714N	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	1824					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						ACTACCTGGTGACCTTCTGGG	0.502													27	58					0	0	0	0	A	40719213	A	A	40719213	3	1	6	1	0	0	0	0	1	0	0	0	16407	1290	45	2	5681	2	TNRC6B	22	40719213	Missense_Mutation	SNP	G	TCGA-BA-5149-01A-01D-1512-08		40719213	10585353	138	1779											
POLR3H	171568	broad.mit.edu	37	chr22	41928719	41928719	+	Frame_Shift_Del	DEL	A	-	-																															caatgagaatctcatctaggAatggatgaaacaccacgcag																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chr22:41928719delA	uc003baf.2	-	4	299	c.239delT	c.(238-240)TTCfs	p.F80fs	POLR3H_uc003bae.2_RNA|POLR3H_uc003bag.2_Frame_Shift_Del_p.F80fs|POLR3H_uc003bai.2_Intron	NM_138338	NP_612211	Q9Y535	RPC8_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	80					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			skin(1)	1						CTCATCTAGGAATGGATGAAA	0.547											OREG0026590	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	41928719	-	-	41928719	7	5	6	1	0	1	0	1	0	0	0	0	12291	246	9	0	391	0	POLR3H	22	41928719	Frame_Shift_Del	DEL	A	TCGA-BA-5149-01A-01D-1512-08	1209506	41928719	9375847	139	1780											
ASB9	140462	broad.mit.edu	37	chrX	15268558	15268558	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctttttgctttacctgactCcagaagcttcttgacacagg	8	14	8	11	0	1	3	0	2	1	1	2	3	2	3	2	1	3	3	2	1	2	6			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chrX:15268558C>A	uc004cwl.2	-	5	809	c.562G>T	c.(562-564)GAG>TAG	p.E188*	ASB9_uc004cwk.2_Nonsense_Mutation_p.E188*|ASB9_uc004cwm.2_Nonsense_Mutation_p.E178*|ASB9_uc010ner.2_Nonsense_Mutation_p.E188*|ASB9_uc004cwn.2_Nonsense_Mutation_p.E159*	NM_001031739	NP_001026909	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box-containing 9 isoform	188	ANK 5.				intracellular signal transduction						0	Hepatocellular(33;0.183)					TTACCTGACTCCAGAAGCTTC	0.348													37	56					4.14481e-20	4.94083e-20	1	0	A	15268558	A	A	15268558	4	1	6	1	0	0	0	0	0	1	0	0	1032	864	30	2	363	2	ASB9	23	15268558	Nonsense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08		15268558	140002002	140	1781											
SLC7A3	84889	broad.mit.edu	37	chrX	70149727	70149728	+	Missense_Mutation	DNP	CC	TA	TA																															acccaatgtgctgcccacacCcagggccactaaatccaggg																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chrX:70149727_70149728CC>TA	uc004dyn.2	-	2	278_279	c.120_121GG>TA	c.(118-123)CTGGGT>CTTAGT	p.G41S	SLC7A3_uc004dyo.2_Missense_Mutation_p.G41S	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	41	Helical; Name=1; (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CTGCCCACACCCAGGGCCACTA	0.559													7	28					0	0	0	0	TA	70149728	TA	TA	70149727	3	4	6	1	0	0	0	0	1	0	0	0	14762	623	22	4	1782	4	SLC7A3	23	70149727	Missense_Mutation	DNP	CC	TCGA-BA-5149-01A-01D-1512-08	54881169	70149727	85120833	141	1782											
GUCY2F	2986	broad.mit.edu	37	chrX	108619355	108619355	+	Frame_Shift_Del	DEL	T	-	-																															ggaaggggcttcatgaagccTtttttcccaatcagccagaa																										TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chrX:108619355delT	uc004eod.3	-	18	3468	c.3192delA	c.(3190-3192)AAAfs	p.K1064fs	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	1064	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TCATGAAGCCTTTTTTCCCAA	0.418													---	---	---								-	108619355	-	-	108619355	7	5	6	1	0	1	0	1	0	0	0	0	6937	1606	56	0	142	0	GUCY2F	23	108619355	Frame_Shift_Del	DEL	T	TCGA-BA-5149-01A-01D-1512-08	38469628	108619355	46651205	142	1783											
STAG2	10735	broad.mit.edu	37	chrX	123164834	123164834	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtaaaaaaggcaaaaagggCccagcagaaaagggcaaagg	20	2	13	6	0	0	1	0	0	0	1	0	1	0	1	1	4	1	4	1	4	8	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chrX:123164834C>T	uc004etz.3	+	4	486	c.147C>T	c.(145-147)GGC>GGT	p.G49G	STAG2_uc004eua.2_Silent_p.G49G|STAG2_uc004eub.2_Silent_p.G49G|STAG2_uc004euc.2_Silent_p.G49G|STAG2_uc004eud.2_Silent_p.G49G|STAG2_uc004eue.2_Silent_p.G49G	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	49					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GCAAAAAGGGCCCAGCAGAAA	0.418													76	31					0	0	0	0	T	123164834	T	T	123164834	2	4	6	1	0	0	0	0	0	0	0	1	15309	726	26	4		4	STAG2	23	123164834	Silent	SNP	C	TCGA-BA-5149-01A-01D-1512-08	14545479	123164834	32105726	143	1784											
IRAK1	3654	broad.mit.edu	37	chrX	153278545	153278545	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actcccccagctcgattctcCtgccgtgtccccctgaggac	5	9	8	19	2	1	1	0	1	1	0	5	3	3	2	6	1	2	1	6	1	0	1			TCGA-BA-5149-01A-01D-1512-08	TCGA-BA-5149-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e98841c-ce33-4b7e-882d-ce65707d4c10	a86b1ecb-9d55-4acf-9c94-c4b3f761a2cb	g.chrX:153278545C>T	uc004fjs.1	-	12	1958	c.1879G>A	c.(1879-1881)GGA>AGA	p.G627R	IRAK1_uc004fjr.1_Missense_Mutation_p.G597R|IRAK1_uc004fjt.1_Missense_Mutation_p.G548R|IRAK1_uc010nur.2_Intron	NM_001569	NP_001560	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	627					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTCGATTCTCCTGCCGTGTCC	0.687													16	15					0	0	0	0	T	153278545	T	T	153278545	3	4	6	1	0	0	0	0	1	0	0	0	7860	690	24	4	271	4	IRAK1	23	153278545	Missense_Mutation	SNP	C	TCGA-BA-5149-01A-01D-1512-08	30113711	153278545	1992015	144	1785											
MRPL20	55052	broad.mit.edu	37	chr1	1342362	1342362	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgaatcacggttctgaccGccaacctgtagcagcgattt	9	10	9	13	4	2	1	1	1	1	0	3	3	2	1	3	1	3	3	3	1	3	3			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:1342362G>A	uc001afo.3	-	2	221	c.125C>T	c.(124-126)GCG>GTG	p.A42V	MRPL20_uc010nyn.1_Missense_Mutation_p.A42V	NM_017971	NP_060441	Q9BYC9	RM20_HUMAN	mitochondrial ribosomal protein L20 precursor	42							protein binding|rRNA binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGTTCTGACCGCCAACCTGTA	0.488													6	422					0	0	0	0	A	1342362	A	A	1342362	3	1	7	1	0	0	0	0	1	0	0	0	9839	1087	38	1	336	1	MRPL20	1	1342362	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08		1342362	247908259	1	1786											
TNFRSF25	8718	broad.mit.edu	37	chr1	6521694	6521694	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcgcgcagccccagcgtgcGcacgaactccttccagcgcc	6	5	10	20	6	0	0	0	0	0	0	3	1	2	0	5	0	5	2	5	0	1	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:6521694G>A	uc001ane.2	-	10	1142	c.1054C>T	c.(1054-1056)CGC>TGC	p.R352C	TNFRSF25_uc001ana.2_Missense_Mutation_p.R169C|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_Missense_Mutation_p.R125C|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Missense_Mutation_p.R315C|TNFRSF25_uc001ang.2_Missense_Mutation_p.R307C|TNFRSF25_uc001anh.2_Missense_Mutation_p.R361C	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	352	Death.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CCCAGCGTGCGCACGAACTCC	0.687													8	35					0	0	0	0	A	6521694	A	A	6521694	3	1	7	1	0	0	0	0	1	0	0	0	16362	1087	38	1	203	1	TNFRSF25	1	6521694	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	5179332	6521694	242728927	2	1787											
MYCL1	4610	broad.mit.edu	37	chr1	40366778	40366778	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccaggagcgagccggtcgCtcacagctctctccagccgt	6	6	12	17	5	2	0	1	0	1	0	5	2	3	1	4	2	4	2	4	2	0	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:40366778C>T	uc001cer.1	-	2	546	c.329G>A	c.(328-330)AGC>AAC	p.S110N	MYCL1_uc001ces.1_Missense_Mutation_p.S110N|MYCL1_uc001cet.1_Missense_Mutation_p.S110N	NM_001033082	NP_001028254	P12524	MYCL1_HUMAN	l-myc-1 proto-oncogene isoform 1	110						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|liver(1)	2	all_cancers(7;1.73e-14)|all_lung(5;2.77e-17)|all_epithelial(6;6.81e-17)|Lung SC(1;2.85e-13)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.51e-19)|Epithelial(16;3.36e-18)|all cancers(16;8.43e-17)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAGCCGGTCGCTCACAGCTCT	0.726			A		small cell lung 								3	16					0	0	0	0	T	40366778	T	T	40366778	3	4	7	1	0	0	0	0	1	0	0	0	10073	797	28	4	898	4	MYCL1	1	40366778	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	33845084	40366778	208883843	3	1788											
CRYZ	1429	broad.mit.edu	37	chr1	75172795	75172795	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaatacttactatcactcGtcctccatgtgacagaagac	13	10	7	11	1	1	3	1	1	0	2	4	4	3	4	2	1	2	0	2	1	5	3			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:75172795G>A	uc001dgk.2	-	8	1229	c.724C>T	c.(724-726)CGA>TGA	p.R242*	CRYZ_uc001dgj.2_Nonsense_Mutation_p.R242*|CRYZ_uc001dgl.2_Intron|CRYZ_uc001dgm.2_Nonsense_Mutation_p.R105*	NM_001130042	NP_001123514	Q08257	QOR_HUMAN	crystallin, zeta isoform a	242					protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)	ACTATCACTCGTCCTCCATGT	0.274													34	145					0	0	0	0	A	75172795	A	A	75172795	4	1	7	1	0	0	0	0	0	1	0	0	3937	1153	40	1	277	1	CRYZ	1	75172795	Nonsense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	34806017	75172795	174077826	4	1789											
SNX7	51375	broad.mit.edu	37	chr1	99161197	99161197	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggagttcatggaaatgaatAactttattgaactatttagc	15	14	8	4	0	1	2	1	2	0	0	1	4	1	4	0	2	3	1	0	2	7	8			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:99161197A>G	uc010ouc.1	+	5	815	c.763A>G	c.(763-765)AAC>GAC	p.N255D	SNX7_uc001dsa.2_Missense_Mutation_p.N191D|SNX7_uc010oud.1_Missense_Mutation_p.N200D	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	191					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		GGAAATGAATAACTTTATTGA	0.383													23	113					0	0	0	0	G	99161197	G	G	99161197	3	3	7	1	0	0	0	0	1	0	0	0	14971	362	13	5	781	5	SNX7	1	99161197	Missense_Mutation	SNP	A	TCGA-BA-5151-01A-01D-1434-08	23988402	99161197	150089424	5	1790											
HRNR	388697	broad.mit.edu	37	chr1	152187690	152187690	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctagatgactgtcctgatcTagagccgtgttgtccgtagc	7	12	11	11	2	1	4	0	2	1	2	3	4	3	4	4	0	2	2	4	0	3	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:152187690T>A	uc001ezt.1	-	3	6491	c.6415A>T	c.(6415-6417)AGA>TGA	p.R2139*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2139					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTGATCTAGAGCCGTGT	0.572													16	696					0	0	0	0	A	152187690	A	A	152187690	4	1	7	1	0	0	0	0	0	1	0	0	7398	1530	53	5	2141	5	HRNR	1	152187690	Nonsense_Mutation	SNP	T	TCGA-BA-5151-01A-01D-1434-08	53026493	152187690	97062931	6	1791											
HRNR	388697	broad.mit.edu	37	chr1	152191224	152191224	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgactgtcctgacctagagcCgtgttgttcgtagctggagg	6	12	14	9	2	0	3	0	2	0	1	2	4	1	4	3	2	2	4	3	2	2	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:152191224C>T	uc001ezt.1	-	3	2957	c.2881G>A	c.(2881-2883)GGC>AGC	p.G961S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	961	10.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCTAGAGCCGTGTTGTTCG	0.537													102	382					0	0	0	0	T	152191224	T	T	152191224	3	4	7	1	0	0	0	0	1	0	0	0	7398	652	23	1	5675	1	HRNR	1	152191224	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	3534	152191224	97059397	7	1792											
OR10T2	128360	broad.mit.edu	37	chr1	158368907	158368907	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcgatcatatcccatcacaGcaatgaggaggcagttggtg	12	8	12	9	1	2	1	2	1	0	0	3	3	3	2	1	3	2	3	1	3	2	2			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:158368907G>A	uc010pih.1	-	1	350	c.350C>T	c.(349-351)GCT>GTT	p.A117V		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					TCCCATCACAGCAATGAGGAG	0.493													4	155					0	0	0	0	A	158368907	A	A	158368907	3	1	7	1	0	0	0	0	1	0	0	0	10973	971	34	4	596	4	OR10T2	1	158368907	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	6177683	158368907	90881714	8	1793											
FAM5C	339479	broad.mit.edu	37	chr1	190423836	190423836	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccggcttctgtccacaaaaTctgtgtattcctgtgagcga	8	12	10	11	2	2	1	0	1	2	0	4	2	4	1	3	1	1	2	3	1	3	3			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:190423836T>G	uc001gse.1	-	2	417	c.185A>C	c.(184-186)GAT>GCT	p.D62A	FAM5C_uc010pot.1_Missense_Mutation_p.I24L	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	62						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GTCCACAAAATCTGTGTATTC	0.468													18	64					0	0	0	0	G	190423836	G	G	190423836	3	3	7	1	0	0	0	0	1	0	0	0	5626	1435	50	5	2143	5	FAM5C	1	190423836	Missense_Mutation	SNP	T	TCGA-BA-5151-01A-01D-1434-08	32054929	190423836	58826785	9	1794											
CACNA1S	779	broad.mit.edu	37	chr1	201012531	201012531	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggaagtcctccaagaaGacaggtgactccatctcttc	10	10	10	11	0	1	3	0	1	1	2	6	4	4	4	3	2	0	0	3	2	3	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr1:201012531G>T	uc001gvv.2	-	40	5153	c.4926C>A	c.(4924-4926)GTC>GTA	p.V1642V		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1642	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCTCCAAGAAGACAGGTGACT	0.542											OREG0014067	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	112					3.11337e-16	3.55034e-16	1	0	T	201012531	T	T	201012531	2	4	7	1	0	0	0	0	0	0	0	1	2559	929	33	2		2	CACNA1S	1	201012531	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	10588695	201012531	48238090	10	1795											
PXDN	7837	broad.mit.edu	37	chr2	1667514	1667514	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacaggaccaggtgccgcCggtccacggagagctggctc	8	5	15	13	3	0	2	0	1	0	1	2	4	1	3	4	5	2	2	4	5	0	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:1667514C>T	uc002qxa.2	-	12	1494	c.1430G>A	c.(1429-1431)CGG>CAG	p.R477Q	PXDN_uc002qxb.1_Missense_Mutation_p.R477Q	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	477	Ig-like C2-type 3.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CAGGTGCCGCCGGTCCACGGA	0.602													5	139					0	0	0	0	T	1667514	T	T	1667514	3	4	7	1	0	0	0	0	1	0	0	0	12912	652	23	1	3057	1	PXDN	2	1667514	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08		1667514	241531859	11	1796											
CTNNA2	1496	broad.mit.edu	37	chr2	80101317	80101317	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctccgccacccagatgtcgCcgctacgagagccaaccgag	9	5	10	17	5	1	2	0	0	1	2	3	4	1	2	6	0	3	1	6	0	2	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:80101317C>T	uc010ysh.1	+	5	706	c.701C>T	c.(700-702)GCC>GTC	p.A234V	CTNNA2_uc010yse.1_Missense_Mutation_p.A234V|CTNNA2_uc010ysf.1_Missense_Mutation_p.A234V|CTNNA2_uc010ysg.1_Missense_Mutation_p.A234V	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	234					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CCAGATGTCGCCGCTACGAGA	0.582													38	78					0	0	0	0	T	80101317	T	T	80101317	3	4	7	1	0	0	0	0	1	0	0	0	4030	739	26	4	719	4	CTNNA2	2	80101317	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	78433803	80101317	163098056	12	1797											
CTNNA2	1496	broad.mit.edu	37	chr2	80620359	80620359	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaggaaagaaaaaggagaTcctctcaacattgcgattga	17	7	11	6	1	1	3	1	1	1	2	3	7	2	5	1	3	2	0	1	3	5	2			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:80620359T>C	uc010ysh.1	+	7	1085	c.1080T>C	c.(1078-1080)GAT>GAC	p.D360D	CTNNA2_uc010yse.1_Silent_p.D360D|CTNNA2_uc010ysf.1_Silent_p.D360D|CTNNA2_uc010ysg.1_Silent_p.D360D|CTNNA2_uc010ysi.1_5'UTR	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	360					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AAAAAGGAGATCCTCTCAACA	0.284													63	118					0	0	0	0	C	80620359	C	C	80620359	2	2	7	1	0	0	0	0	0	0	0	1	4030	1432	50	5		5	CTNNA2	2	80620359	Silent	SNP	T	TCGA-BA-5151-01A-01D-1434-08	519042	80620359	162579014	13	1798											
GPR45	11250	broad.mit.edu	37	chr2	105858997	105858997	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggtccgcaagaacgccgtgCgcgtgcacaaccagtcggac	9	4	13	15	7	0	1	0	0	0	1	2	2	1	2	3	2	4	2	3	2	3	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:105858997C>T	uc002tco.1	+	1	798	c.682C>T	c.(682-684)CGC>TGC	p.R228C		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	228	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						GAACGCCGTGCGCGTGCACAA	0.652													5	150					0	0	0	0	T	105858997	T	T	105858997	3	4	7	1	0	0	0	0	1	0	0	0	6734	768	27	1	684	1	GPR45	2	105858997	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	25238638	105858997	137340376	14	1799											
MARCH7	64844	broad.mit.edu	37	chr2	160585576	160585576	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccaagaagaatttctgttCaaccttccagctccttaagt	11	14	5	11	0	2	2	1	0	1	2	5	2	5	2	4	0	2	2	4	0	5	5			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:160585576C>T	uc002uax.2	+	2	165	c.43C>T	c.(43-45)CAA>TAA	p.Q15*	MARCH7_uc010foq.2_Nonsense_Mutation_p.Q15*|MARCH7_uc010zcn.1_Nonsense_Mutation_p.Q15*	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	15	Ser-rich.						ligase activity|zinc ion binding				0						AATTTCTGTTCAACCTTCCAG	0.343													34	70					0	0	0	0	T	160585576	T	T	160585576	4	4	7	1	0	0	0	0	0	1	0	0	9359	827	29	2	45	2	MARCH7	2	160585576	Nonsense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	54726579	160585576	82613797	15	1800											
SESTD1	91404	broad.mit.edu	37	chr2	179979882	179979882	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattgtttccatactctgttCagtcgaggaagtgtatcccc	9	14	8	10	1	2	0	1	0	1	0	5	2	4	1	3	1	1	3	3	1	4	5			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:179979882C>A	uc002uni.3	-	16	1899	c.1749G>T	c.(1747-1749)CTG>CTT	p.L583L	SESTD1_uc002unh.3_Silent_p.L86L	NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	583	Spectrin 3.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			ATACTCTGTTCAGTCGAGGAA	0.433													21	66					4.96729e-08	5.42645e-08	1	0	A	179979882	A	A	179979882	2	1	7	1	0	0	0	0	0	0	0	1	14192	813	29	2		2	SESTD1	2	179979882	Silent	SNP	C	TCGA-BA-5151-01A-01D-1434-08	19394306	179979882	63219491	16	1801											
SSFA2	6744	broad.mit.edu	37	chr2	182767033	182767033	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattgtagaatccaaattagAtagtgatttcaacatatcca	16	14	5	6	0	1	3	1	1	0	2	3	3	3	3	2	0	1	1	2	0	8	7			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:182767033A>G	uc002uoi.2	+	8	1575	c.1253A>G	c.(1252-1254)GAT>GGT	p.D418G	SSFA2_uc002uoh.2_Missense_Mutation_p.D418G|SSFA2_uc002uoj.2_Missense_Mutation_p.D418G|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.D265G|SSFA2_uc002uol.2_Missense_Mutation_p.D265G	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	418						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TCCAAATTAGATAGTGATTTC	0.383													15	84					0	0	0	0	G	182767033	G	G	182767033	3	3	7	1	0	0	0	0	1	0	0	0	15249	333	12	5	1283	5	SSFA2	2	182767033	Missense_Mutation	SNP	A	TCGA-BA-5151-01A-01D-1434-08	2787151	182767033	60432340	17	1802											
CASP8	841	broad.mit.edu	37	chr2	202149679	202149688	+	Frame_Shift_Del	DEL	CTCTCCCATG	-	-																															actgcttcatctgctgtatcCtctcccatggagacaagggc																										TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:202149679_202149688delCTCTCCCATG	uc002uxr.1	+	9	1152_1161	c.943_952delCTCTCCCATG	c.(943-954)CTCTCCCATGGAfs	p.L315fs	CASP8_uc002uxp.1_Frame_Shift_Del_p.L332fs|CASP8_uc002uxq.1_Frame_Shift_Del_p.L300fs|CASP8_uc002uxt.1_Frame_Shift_Del_p.L374fs|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Frame_Shift_Del_p.L300fs|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Frame_Shift_Del_p.L231fs	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	315_318					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CTGCTGTATCCTCTCCCATGGAGACAAGGG	0.486										HNSCC(4;0.00038)			---	---	---								-	202149688	-	-	202149679	7	5	7	1	0	1	0	1	0	0	0	0	2689	681	24	0	1250	0	CASP8	2	202149679	Frame_Shift_Del	DEL	CTCTCCCATG	TCGA-BA-5151-01A-01D-1434-08	19382646	202149679	41049694	18	1803											
NPPC	4880	broad.mit.edu	37	chr2	232790411	232790412	+	Frame_Shift_Ins	INS	-	G	G																															cggccagctcctctgccggcINSggggttcgcgggacctgtcc																										TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr2:232790411_232790412insG	uc002vsl.1	-	2	104_105	c.104_105insC	c.(103-105)CCGfs	p.P35fs		NM_024409	NP_077720	P23582	ANFC_HUMAN	natriuretic peptide precursor C precursor	35					cGMP biosynthetic process|growth plate cartilage chondrocyte differentiation|growth plate cartilage chondrocyte proliferation|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vasoconstriction		hormone activity				0		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;9.35e-14)|BRCA - Breast invasive adenocarcinoma(100;0.00119)|LUSC - Lung squamous cell carcinoma(224;0.00746)|Lung(119;0.00834)		CCTCTGCCGGCGGGGTTCGCGG	0.743													---	---	---								G	232790412	G	G	232790411	7	5	7	1	0	1	1	0	0	0	0	0	10647	755	27	0	279	0	NPPC	2	232790411	Frame_Shift_Ins	INS	-	TCGA-BA-5151-01A-01D-1434-08	30640732	232790411	10408962	19	1804											
GRM7	2917	broad.mit.edu	37	chr3	6903213	6903213	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgcactcaatccggatcgaGggggacgtcaccctcggggg	7	5	15	14	5	2	0	2	0	0	0	5	3	3	2	3	5	0	1	3	5	1	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:6903213G>A	uc003bqm.2	+	1	412	c.138G>A	c.(136-138)GAG>GAA	p.E46E	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.E46E|GRM7_uc003bql.2_Silent_p.E46E	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	46	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TCCGGATCGAGGGGGACGTCA	0.692													3	12					0	0	0	0	A	6903213	A	A	6903213	2	1	7	1	0	0	0	0	0	0	0	1	6841	991	35	4		4	GRM7	3	6903213	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08		6903213	191119217	20	1805											
ARHGAP31	57514	broad.mit.edu	37	chr3	119084258	119084258	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagtcacctcaaacatacaaCggctaaggtaagctaaaaga	18	6	8	9	1	2	1	2	0	0	1	2	2	2	1	1	2	4	3	1	2	7	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:119084258C>T	uc003ecj.3	+	2	728	c.196C>T	c.(196-198)CGG>TGG	p.R66W		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	66	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						AAACATACAACGGCTAAGGTA	0.438													17	100					0	0	0	0	T	119084258	T	T	119084258	3	4	7	1	0	0	0	0	1	0	0	0	880	527	19	1	202	1	ARHGAP31	3	119084258	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	112181045	119084258	78938172	21	1806											
PLXNA1	5361	broad.mit.edu	37	chr3	126708596	126708596	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcaagctctccctgccgtGgctgctcaacaaggagctgg	7	7	14	13	1	2	0	1	0	1	0	3	1	2	1	2	4	5	5	2	4	3	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:126708596G>A	uc003ejg.2	+	1	1095	c.1091G>A	c.(1090-1092)TGG>TAG	p.W364*		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	387	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		TCCCTGCCGTGGCTGCTCAAC	0.642													32	91					0	0	0	0	A	126708596	A	A	126708596	4	1	7	1	0	0	0	0	0	1	0	0	12174	1357	47	4	1162	4	PLXNA1	3	126708596	Nonsense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	7624338	126708596	71313834	22	1807											
FAIM	55179	broad.mit.edu	37	chr3	138351800	138351800	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtagatgatgggactgaaaCtcacttcagtatcgggaacc	12	10	11	8	1	2	3	2	2	0	1	3	5	2	5	1	2	2	2	1	2	4	3			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:138351800C>A	uc003esr.2	+	5	679	c.419C>A	c.(418-420)ACT>AAT	p.T140N	FAIM_uc003esp.2_Missense_Mutation_p.T174N|FAIM_uc003esq.2_Missense_Mutation_p.T162N|FAIM_uc003ess.2_Missense_Mutation_p.T140N	NM_001033032	NP_001028204	Q9NVQ4	FAIM1_HUMAN	Fas apoptotic inhibitory molecule isoform c	140					apoptosis	cytoplasm					0						GGGACTGAAACTCACTTCAGT	0.413													68	123					1.93348e-29	2.32733e-29	1	0	A	138351800	A	A	138351800	3	1	7	1	0	0	0	0	1	0	0	0	5403	565	20	4	587	4	FAIM	3	138351800	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	11643204	138351800	59670630	23	1808											
XRN1	54464	broad.mit.edu	37	chr3	142098954	142098954	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtattaaagcatcaagattGggttcacatggaatgctgaa	14	12	10	5	0	2	2	2	1	0	1	2	3	2	3	0	2	2	4	0	2	6	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:142098954G>A	uc003eus.2	-	23	2752	c.2685C>T	c.(2683-2685)CCC>CCT	p.P895P	XRN1_uc010huu.2_Silent_p.P361P|XRN1_uc003eut.2_Silent_p.P895P|XRN1_uc003euu.2_Silent_p.P895P|XRN1_uc003euv.1_Silent_p.P756P	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	895					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						CATCAAGATTGGGTTCACATG	0.328													19	79					0	0	0	0	A	142098954	A	A	142098954	2	1	7	1	0	0	0	0	0	0	0	1	17527	1335	47	4		4	XRN1	3	142098954	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	3747154	142098954	55923476	24	1809											
CHRD	8646	broad.mit.edu	37	chr3	184101432	184101432	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagccaggaggacacacggTgagggctccaggtggagctg	9	4	17	11	1	0	1	0	1	0	0	1	4	1	4	3	6	2	2	3	6	0	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:184101432T>C	uc003fov.2	+	12	1686	c.1440_splice	c.e12+2	p.T480_splice	CHRD_uc003fow.2_Splice_Site_p.T110_splice|CHRD_uc003fox.2_Splice_Site_p.T480_splice|CHRD_uc003foy.2_Splice_Site_p.T110_splice|CHRD_uc010hyc.2_Intron|CHRD_uc011brr.1_Splice_Site_p.T110_splice	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor						BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGACACACGGTGAGGGCTCCA	0.607													10	87					0	0	0	0	C	184101432	C	C	184101432	5	2	7	1	0	0	0	0	0	0	1	0	3387	1710	59	5	1488	5	CHRD	3	184101432	Splice_Site	SNP	T	TCGA-BA-5151-01A-01D-1434-08	42002478	184101432	13920998	25	1810											
CPN2	1370	broad.mit.edu	37	chr3	194062951	194062951	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggctggaagagcctcctggGcagggcctggagctggttcc	6	7	17	11	0	0	1	0	0	0	1	2	3	2	3	4	6	2	4	4	6	1	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr3:194062951G>C	uc003fts.2	-	2	571	c.481C>G	c.(481-483)CCC>GCC	p.P161A		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	161	LRR 3.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		AGCCTCCTGGGCAGGGCCTGG	0.637													11	93					0	0	0	0	C	194062951	C	C	194062951	3	2	7	1	0	0	0	0	1	0	0	0	3825	1203	42	4	1160	4	CPN2	3	194062951	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	9961519	194062951	3959479	26	1811											
ENPEP	2028	broad.mit.edu	37	chr4	111430849	111430849	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggcactggtgccatggaGaactggggactcatcacgta	9	10	13	9	1	2	1	2	0	0	1	2	3	2	2	1	5	2	2	1	5	2	2			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr4:111430849G>A	uc003iab.3	+	5	1422	c.1080G>A	c.(1078-1080)GAG>GAA	p.E360E		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	360	Substrate binding (By similarity).|Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GTGCCATGGAGAACTGGGGAC	0.443													25	132					0	0	0	0	A	111430849	A	A	111430849	2	1	7	1	0	0	0	0	0	0	0	1	5152	933	33	2		2	ENPEP	4	111430849	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08		111430849	79723427	27	1812											
PCDHGB2	56103	broad.mit.edu	37	chr5	140741347	140741347	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagcgccaacgtgagcctgCgcgtgttagtgggcgacctc	6	8	14	13	5	1	1	1	1	0	0	2	2	1	1	3	1	4	1	3	1	2	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:140741347C>T	uc003ljs.1	+	1	1645	c.1645C>T	c.(1645-1647)CGC>TGC	p.R549C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.R549C|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	549	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGAGCCTGCGCGTGTTAGT	0.697													21	103					0	0	0	0	T	140741347	T	T	140741347	3	4	7	1	0	0	0	0	1	0	0	0	11617	768	27	1	1647	1	PCDHGB2	5	140741347	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08		140741347	40173913	28	1813											
HAVCR1	26762	broad.mit.edu	37	chr5	156456763	156456763	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttagtccgtggcataaagaCtattctcaatgtagatattg	12	14	8	7	1	1	2	1	0	1	2	3	2	2	2	1	1	0	2	1	1	7	7			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:156456763C>T	uc010jij.1	-	9	1261	c.1076G>A	c.(1075-1077)AGT>AAT	p.S359N	HAVCR1_uc011ddl.1_Missense_Mutation_p.V179I|HAVCR1_uc003lwi.2_Missense_Mutation_p.S359N	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	354	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGCATAAAGACTATTCTCAAT	0.408													15	61					0	0	0	0	T	156456763	T	T	156456763	3	4	7	1	0	0	0	0	1	0	0	0	7012	565	20	4	22	4	HAVCR1	5	156456763	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	15715416	156456763	24458497	29	1814											
GABRG2	2566	broad.mit.edu	37	chr5	161524781	161524781	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacactttcttcagaaattcCaaaaaagctgatgcacactg	15	10	6	10	0	2	2	1	1	1	1	3	3	3	2	1	0	2	2	1	0	4	3			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:161524781C>T	uc003lyz.3	+	4	823	c.465C>T	c.(463-465)TCC>TCT	p.S155S	GABRG2_uc010jjc.2_Silent_p.S155S|GABRG2_uc003lyy.3_Silent_p.S155S|GABRG2_uc011dej.1_Silent_p.S60S	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	155	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		TCAGAAATTCCAAAAAAGCTG	0.428													38	165					0	0	0	0	T	161524781	T	T	161524781	2	4	7	1	0	0	0	0	0	0	0	1	6206	581	21	4		4	GABRG2	5	161524781	Silent	SNP	C	TCGA-BA-5151-01A-01D-1434-08	5068018	161524781	19390479	30	1815											
RPL26L1	51121	broad.mit.edu	37	chr5	172386987	172386987	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcatccccgctctccaaggaGctgcggcagaagtacaatgt	10	8	10	13	2	2	1	1	0	1	1	4	2	3	2	3	2	3	4	3	2	4	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:172386987G>C	uc003mcc.2	+	2	153	c.111G>C	c.(109-111)GAG>GAC	p.E37D	LOC100268168_uc011dfb.1_5'Flank|LOC100268168_uc011dfc.1_5'Flank	NM_016093	NP_057177	Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	37					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTCCAAGGAGCTGCGGCAGA	0.602													37	180					0	0	0	0	C	172386987	C	C	172386987	3	2	7	1	0	0	0	0	1	0	0	0	13639	962	34	4	113	4	RPL26L1	5	172386987	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	10862206	172386987	8528273	31	1816											
RNF44	22838	broad.mit.edu	37	chr5	175958006	175958006	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcacaggcagctgctgcatgGtgcacgcctggataagctgc	8	7	14	12	1	0	0	0	0	0	0	0	1	0	1	1	3	6	7	1	3	1	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr5:175958006G>C	uc003mek.1	-	5	1007	c.482C>G	c.(481-483)ACC>AGC	p.T161S	RNF44_uc011dfo.1_Missense_Mutation_p.T69S|RNF44_uc003mel.1_5'Flank	NM_014901	NP_055716	Q7L0R7	RNF44_HUMAN	ring finger protein 44	161	Pro-rich.						zinc ion binding				0	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGCTGCATGGTGCACGCCTG	0.667													7	20					0	0	0	0	C	175958006	C	C	175958006	3	2	7	1	0	0	0	0	1	0	0	0	13561	1261	44	4	844	4	RNF44	5	175958006	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	3571019	175958006	4957254	32	1817											
GPLD1	2822	broad.mit.edu	37	chr6	24437400	24437400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccaaatcgggagaagcggCggtctccgctgaaggtgctg	9	6	15	11	4	1	2	0	1	1	1	3	3	1	2	2	4	2	2	2	4	3	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:24437400C>T	uc003ned.1	-	21	2249	c.2138G>A	c.(2137-2139)CGC>CAC	p.R713H		NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	713	FG-GAP 6.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						GGAGAAGCGGCGGTCTCCGCT	0.562													22	116					0	0	0	0	T	24437400	T	T	24437400	3	4	7	1	0	0	0	0	1	0	0	0	6652	768	27	1	404	1	GPLD1	6	24437400	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08		24437400	146677667	33	1818											
MAS1L	116511	broad.mit.edu	37	chr6	29455445	29455445	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccagcacagccttgggggCaatgatattcaagggcaggg	11	6	15	9	0	1	1	1	1	0	0	1	2	1	1	2	4	2	3	2	4	3	3			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:29455445C>A	uc011dlq.1	-	1	235	c.235G>T	c.(235-237)GCC>TCC	p.A79S		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	79	Helical; Name=1; (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						GCCTTGGGGGCAATGATATTC	0.512													24	67					3.08376e-08	3.39737e-08	1	0	A	29455445	A	A	29455445	3	1	7	1	0	0	0	0	1	0	0	0	9374	710	25	4	903	4	MAS1L	6	29455445	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	5018045	29455445	141659622	34	1819											
TULP1	7287	broad.mit.edu	37	chr6	35467758	35467758	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgggccctcaggtactcacGgtcatcagcgtggacaatct	8	9	11	13	2	5	0	4	0	1	0	5	1	5	1	1	4	2	1	1	4	2	1	rs138772407	byFrequency	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:35467758G>A	uc003okv.3	-	14	1507	c.1495C>T	c.(1495-1497)CCC>TCC	p.P499S	TEAD3_uc003oku.3_5'Flank|TEAD3_uc010jvx.2_5'Flank|TULP1_uc003okw.3_Missense_Mutation_p.P446S	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	499					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						AGGTACTCACGGTCATCAGCG	0.587													71	107					0	0	0	0	A	35467758	A	A	35467758	3	1	7	1	0	0	0	0	1	0	0	0	16841	1130	39	1	141	1	TULP1	6	35467758	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	6012313	35467758	135647309	35	1820											
DST	667	broad.mit.edu	37	chr6	56489977	56489977	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgaataatgagatctgctGaactctgcattcttcggcgt	9	14	9	9	2	3	3	0	3	3	1	4	4	3	3	0	1	3	2	0	1	3	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:56489977G>T	uc003pdf.2	-	34	4737	c.4709C>A	c.(4708-4710)TCA>TAA	p.S1570*	DST_uc003pcz.3_Nonsense_Mutation_p.S1392*|DST_uc011dxj.1_Nonsense_Mutation_p.S1421*|DST_uc011dxk.1_Nonsense_Mutation_p.S1432*|DST_uc003pcy.3_Nonsense_Mutation_p.S1066*|DST_uc003pdb.2_Nonsense_Mutation_p.S1066*|DST_uc003pdc.3_Nonsense_Mutation_p.S1066*|DST_uc003pdd.3_Nonsense_Mutation_p.S1066*	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1392					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GAGATCTGCTGAACTCTGCAT	0.353													63	273					4.60343e-24	5.44042e-24	1	0	T	56489977	T	T	56489977	4	4	7	1	0	0	0	0	0	1	0	0	4805	1294	45	2	17214	2	DST	6	56489977	Nonsense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	21022219	56489977	114625090	36	1821											
PRDM1	639	broad.mit.edu	37	chr6	106552717	106552717	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcacaaacacagagcagtCtaaagcaaccgagcactgag	17	3	9	12	1	1	2	0	1	1	1	1	3	1	2	1	0	6	4	1	0	4	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:106552717C>T	uc003prd.2	+	5	916	c.682C>T	c.(682-684)CTA>TTA	p.L228L	PRDM1_uc003pre.2_Silent_p.L94L	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	228					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		ACAGAGCAGTCTAAAGCAACC	0.448			D|N|Mis|F|S		DLBCL								70	332					0	0	0	0	T	106552717	T	T	106552717	2	4	7	1	0	0	0	0	0	0	0	1	12512	912	32	2		2	PRDM1	6	106552717	Silent	SNP	C	TCGA-BA-5151-01A-01D-1434-08	50062740	106552717	64562350	37	1822											
ARID1B	57492	broad.mit.edu	37	chr6	157528080	157528080	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actcctctgtgtaccatcgcGcactggcaggactcgctggc	6	9	11	15	3	1	0	0	0	1	0	4	1	2	1	2	3	1	4	2	3	1	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr6:157528080G>A	uc003qqn.2	+	20	5903	c.5751G>A	c.(5749-5751)GCG>GCA	p.A1917A	ARID1B_uc003qqo.2_Silent_p.A1877A|ARID1B_uc003qqp.2_Silent_p.A1864A	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1922					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GTACCATCGCGCACTGGCAGG	0.537													37	147					0	0	0	0	A	157528080	A	A	157528080	2	1	7	1	0	0	0	0	0	0	0	1	914	1074	38	1		1	ARID1B	6	157528080	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	50975363	157528080	13586987	38	1823											
COBL	23242	broad.mit.edu	37	chr7	51203960	51203960	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acccctgagatgctgcccagCgagagggatggacccagcgt	9	5	14	13	2	0	2	0	1	0	2	0	6	0	4	4	2	4	1	4	2	0	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:51203960C>T	uc003tpr.3	-	6	1037	c.852G>A	c.(850-852)TCG>TCA	p.S284S	COBL_uc003tps.2_Silent_p.S284S|COBL_uc011kcl.1_Silent_p.S284S|COBL_uc010kzc.2_Silent_p.S284S|COBL_uc003tpt.2_Silent_p.S284S|COBL_uc003tpp.3_Silent_p.S13S|COBL_uc003tpq.3_Silent_p.S225S	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	284										skin(3)|ovary(2)	5	Glioma(55;0.08)					TGCTGCCCAGCGAGAGGGATG	0.577													14	69					0	0	0	0	T	51203960	T	T	51203960	2	4	7	1	0	0	0	0	0	0	0	1	3668	755	27	1		1	COBL	7	51203960	Silent	SNP	C	TCGA-BA-5151-01A-01D-1434-08		51203960	107934703	39	1824											
MUC17	140453	broad.mit.edu	37	chr7	100696279	100696279	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catctcagctgcgtgaccacGgaaactcactggtacagtgg	10	8	11	12	2	2	1	2	1	1	0	3	2	2	2	1	3	4	2	1	3	2	1	rs146965923		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:100696279G>A	uc003uxp.1	+	10	13169	c.13116G>A	c.(13114-13116)ACG>ACA	p.T4372T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4372	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCGTGACCACGGAAACTCACT	0.602													19	102					0	0	0	0	A	100696279	A	A	100696279	2	1	7	1	0	0	0	0	0	0	0	1	10027	1103	39	1		1	MUC17	7	100696279	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	49492319	100696279	58442384	40	1825											
SLC26A4	5172	broad.mit.edu	37	chr7	107330644	107330644	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccaccactgctctttccCgcacggccgtccaggagagc	6	7	11	17	3	1	1	0	0	1	1	3	2	3	1	5	3	2	2	5	3	0	1	rs147952620	by1000genomes	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:107330644C>T	uc003vep.2	+	10	1449	c.1225C>T	c.(1225-1227)CGC>TGC	p.R409C	SLC26A4_uc011kmb.1_5'Flank|SLC26A4_uc011kmc.1_5'Flank	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	409	Extracellular (Potential).		R -> H (in PDS).|R -> P (in DFNB4).		regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						TGCTCTTTCCCGCACGGCCGT	0.493									Pendred_syndrome				42	145					0	0	0	0	T	107330644	T	T	107330644	3	4	7	1	0	0	0	0	1	0	0	0	14583	652	23	1	1259	1	SLC26A4	7	107330644	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	6634365	107330644	51808019	41	1826											
GCC1	79571	broad.mit.edu	37	chr7	127222240	127222240	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtttttgaggtactccagaTtggctccctccctgctctgg	4	15	10	12	0	1	2	0	1	1	1	4	2	4	2	3	3	2	4	3	3	1	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:127222240T>C	uc003vma.2	-	2	2574	c.2156A>G	c.(2155-2157)AAT>AGT	p.N719S		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	719	Potential.|GRIP.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						GTACTCCAGATTGGCTCCCTC	0.567													43	173					0	0	0	0	C	127222240	C	C	127222240	3	2	7	1	0	0	0	0	1	0	0	0	6320	1493	52	5	175	5	GCC1	7	127222240	Missense_Mutation	SNP	T	TCGA-BA-5151-01A-01D-1434-08	19891596	127222240	31916423	42	1827											
SSPO	23145	broad.mit.edu	37	chr7	149510810	149510810	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcgtgcagccgggtcactgCagctgcctggacctgctgac	5	8	14	14	2	1	1	1	1	0	0	1	2	1	2	3	2	7	4	3	2	0	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr7:149510810C>T	uc010lpk.2	+	72	10095	c.10095C>T	c.(10093-10095)TGC>TGT	p.C3365C		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3365	TIL 5.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGGGTCACTGCAGCTGCCTGG	0.697													13	39					0	0	0	0	T	149510810	T	T	149510810	2	4	7	1	0	0	0	0	0	0	0	1	15255	718	25	4		4	SSPO	7	149510810	Silent	SNP	C	TCGA-BA-5151-01A-01D-1434-08	22288570	149510810	9627853	43	1828											
USP17L2	377630	broad.mit.edu	37	chr8	11996046	11996046	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccagcccccaccgcagcaGgtctcctgctactcagagga	8	5	10	18	1	2	1	1	0	1	1	3	2	2	2	5	2	4	3	5	2	1	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:11996046G>A	uc003wvc.1	-	1	224	c.224C>T	c.(223-225)CCT>CTT	p.P75L	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	75					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						CACCGCAGCAGGTCTCCTGCT	0.572													15	346					0	0	0	0	A	11996046	A	A	11996046	3	1	7	1	0	0	0	0	1	0	0	0	17116	1000	35	4	1372	4	USP17L2	8	11996046	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08		11996046	134367976	44	1829											
RIMS2	9699	broad.mit.edu	37	chr8	104955091	104955091	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcttcattgccacttcccCacccttctccatatatgcca	7	14	2	18	0	3	0	1	0	2	0	6	0	4	0	6	0	2	0	6	0	2	6			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:104955091C>A	uc003yls.2	+	12	2213	c.1972C>A	c.(1972-1974)CAC>AAC	p.H658N	RIMS2_uc003ylp.2_Missense_Mutation_p.H880N|RIMS2_uc003ylw.2_Missense_Mutation_p.H672N|RIMS2_uc003ylq.2_Missense_Mutation_p.H672N|RIMS2_uc003ylr.2_Missense_Mutation_p.H719N|RIMS2_uc003ylt.2_Missense_Mutation_p.H265N	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	942					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.Y658S(1)		ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GCCACTTCCCCACCCTTCTCC	0.388										HNSCC(12;0.0054)			22	130					5.45024e-15	6.10803e-15	1	0	A	104955091	A	A	104955091	3	1	7	1	0	0	0	0	1	0	0	0	13433	594	21	4	2818	4	RIMS2	8	104955091	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	92959045	104955091	41408931	45	1830											
ENY2	56943	broad.mit.edu	37	chr8	110346614	110346614	+	5'Flank	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctactgagggtctaagtccGggcagccgaagagtgtggta	9	8	16	8	2	1	2	0	1	1	1	2	3	2	2	2	3	2	3	2	3	4	3			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:110346614G>A	uc003ynd.2	+						NUDCD1_uc003ynb.3_5'Flank|NUDCD1_uc010mcl.2_5'Flank|ENY2_uc003ync.2_5'UTR	NM_020189	NP_064574	Q9NPA8	ENY2_HUMAN	enhancer of yellow 2 homolog						histone deubiquitination|mRNA transport|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity				0	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;9.05e-13)			GTCTAAGTCCGGGCAGCCGAA	0.597													6	38					0	0	0	0	A	110346614	A	A	110346614	1	1	7	0	1	0	0	0	0	0	0	0	5170	1131	39	1		1	ENY2	8	110346614	5'Flank	SNP	G	TCGA-BA-5151-01A-01D-1434-08	5391523	110346614	36017408	46	1831											
CSMD3	114788	broad.mit.edu	37	chr8	113662425	113662425	+	Frame_Shift_Del	DEL	T	-	-																															gtggatgactccaccagtggTttttttcgcatagaaggggc																										TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:113662425delT	uc003ynu.2	-	19	3317	c.3158delA	c.(3157-3159)AACfs	p.N1053fs	CSMD3_uc003yns.2_Frame_Shift_Del_p.N325fs|CSMD3_uc003ynt.2_Frame_Shift_Del_p.N1013fs|CSMD3_uc011lhx.1_Frame_Shift_Del_p.N949fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1053	Extracellular (Potential).|Sushi 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCACCAGTGGTTTTTTTCGCA	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---								-	113662425	-	-	113662425	7	5	7	1	0	1	0	1	0	0	0	0	3963	1725	60	0	8177	0	CSMD3	8	113662425	Frame_Shift_Del	DEL	T	TCGA-BA-5151-01A-01D-1434-08	3315811	113662425	32701597	47	1832											
FAM83H	286077	broad.mit.edu	37	chr8	144810795	144810795	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacaagcggctcggactgcGcgaagaggatgcggaactcc	10	4	15	12	5	0	1	0	0	0	1	2	5	1	4	1	4	4	2	1	4	3	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr8:144810795G>A	uc003yzk.2	-	5	905	c.836C>T	c.(835-837)GCG>GTG	p.A279V	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	279					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTCGGACTGCGCGAAGAGGAT	0.672													4	44					0	0	0	0	A	144810795	A	A	144810795	3	1	7	1	0	0	0	0	1	0	0	0	5672	1087	38	1	2707	1	FAM83H	8	144810795	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	31148370	144810795	1553227	48	1833											
GADD45G	10912	broad.mit.edu	37	chr9	92220945	92220945	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcagcctgttttgcgaggAgagccgcagcgttaacgact	8	9	13	11	4	1	1	1	0	0	1	1	4	1	1	2	1	5	4	2	1	1	3			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:92220945A>C	uc004aqq.2	+	4	541	c.431A>C	c.(430-432)GAG>GCG	p.E144A	GADD45G_uc004aqr.2_Missense_Mutation_p.E126A	NM_006705	NP_006696	O95257	GA45G_HUMAN	growth arrest and DNA-damage-inducible, gamma	144					activation of MAPKKK activity|apoptosis|cell differentiation|DNA repair|multicellular organismal development		protein binding				0						TTTTGCGAGGAGAGCCGCAGC	0.682													4	30					0	0	0	0	C	92220945	C	C	92220945	3	2	7	1	0	0	0	0	1	0	0	0	6217	304	11	5	445	5	GADD45G	9	92220945	Missense_Mutation	SNP	A	TCGA-BA-5151-01A-01D-1434-08		92220945	48992486	49	1834											
KIAA1529	57653	broad.mit.edu	37	chr9	100075586	100075586	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaggaagagctacgagagcGctctggccagctttcaggag	11	6	15	9	2	2	3	1	0	1	3	2	6	2	5	1	3	4	3	1	3	2	2			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:100075586G>A	uc011lut.1	+	17	1740	c.967G>A	c.(967-969)GCT>ACT	p.A323T	KIAA1529_uc004axe.1_Missense_Mutation_p.A323T|KIAA1529_uc004axg.1_Missense_Mutation_p.A184T|KIAA1529_uc011lus.1_Missense_Mutation_p.A184T|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.A184T|KIAA1529_uc011luv.1_Missense_Mutation_p.A184T	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				CTACGAGAGCGCTCTGGCCAG	0.542													18	135					0	0	0	0	A	100075586	A	A	100075586	3	1	7	1	0	0	0	0	1	0	0	0	8279	1087	38	1	997	1	KIAA1529	9	100075586	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	7854641	100075586	41137845	50	1835											
NCBP1	4686	broad.mit.edu	37	chr9	100424349	100424349	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggattcagttttaacccattGaaaatagaagtctttgtaca	14	14	7	6	0	2	2	1	1	1	1	2	3	2	3	1	1	2	2	1	1	6	7			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr9:100424349G>A	uc004axq.2	+	17	2085	c.1626G>A	c.(1624-1626)TTG>TTA	p.L542L		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	542					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				TTAACCCATTGAAAATAGAAG	0.373													12	96					0	0	0	0	A	100424349	A	A	100424349	2	1	7	1	0	0	0	0	0	0	0	1	10265	1281	45	2		2	NCBP1	9	100424349	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	348763	100424349	40789082	51	1836											
CDC123	8872	broad.mit.edu	37	chr10	12259436	12259436	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctttctgcttttcaagagttCcgatttcatcactcgtgact	7	17	6	11	2	4	2	3	1	1	1	6	3	5	2	1	0	1	2	1	0	1	5			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:12259436C>T	uc001ill.2	+	6	694	c.410C>T	c.(409-411)TCC>TTC	p.S137F	CDC123_uc001ilm.2_Missense_Mutation_p.S137F	NM_006023	NP_006014	O75794	CD123_HUMAN	cell division cycle 123	137					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm				central_nervous_system(1)	1						TTCAAGAGTTCCGATTTCATC	0.368													14	141					0	0	0	0	T	12259436	T	T	12259436	3	4	7	1	0	0	0	0	1	0	0	0	3070	855	30	2	432	2	CDC123	10	12259436	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08		12259436	123275311	52	1837											
C10orf111	221060	broad.mit.edu	37	chr10	15138710	15138710	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaactcttactgcctttctCttttcgggctcaagattccc	6	15	6	14	1	3	1	1	0	2	1	6	1	4	1	2	1	3	2	2	1	3	5			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:15138710C>T	uc001inw.2	-	2	388	c.114G>A	c.(112-114)AAG>AAA	p.K38K	RPP38_uc001iny.3_5'Flank|RPP38_uc009xjm.2_5'Flank|RPP38_uc001inx.3_5'Flank	NM_153244	NP_694976	Q8N326	CJ111_HUMAN	hypothetical protein LOC221060	38						integral to membrane					0						CTGCCTTTCTCTTTTCGGGCT	0.498													36	268					0	0	0	0	T	15138710	T	T	15138710	2	4	7	1	0	0	0	0	0	0	0	1	1589	912	32	2		2	C10orf111	10	15138710	Silent	SNP	C	TCGA-BA-5151-01A-01D-1434-08	2879274	15138710	120396037	53	1838											
ARID5B	84159	broad.mit.edu	37	chr10	63852230	63852230	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcaccggaaaatgagccCgcagaacattggggcggcgc	10	4	14	13	4	0	2	0	1	0	1	0	3	0	3	3	4	3	2	3	4	3	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:63852230C>T	uc001jlt.1	+	10	3034	c.3008C>T	c.(3007-3009)CCG>CTG	p.P1003L		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1003					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					AAAATGAGCCCGCAGAACATT	0.552													38	207					0	0	0	0	T	63852230	T	T	63852230	3	4	7	1	0	0	0	0	1	0	0	0	922	652	23	1	3046	1	ARID5B	10	63852230	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	48713520	63852230	71682517	54	1839											
MYPN	84665	broad.mit.edu	37	chr10	69948722	69948722	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaatagagtttcgcttggaaCgtactcctgttgatgaatca	12	13	9	7	2	1	3	1	2	0	1	3	4	2	4	1	1	2	4	1	1	5	5			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:69948722C>T	uc001jnm.3	+	14	2949	c.2764C>T	c.(2764-2766)CGT>TGT	p.R922C	MYPN_uc001jnn.3_Missense_Mutation_p.R647C|MYPN_uc001jno.3_Missense_Mutation_p.R922C|MYPN_uc009xpt.2_Missense_Mutation_p.R922C|MYPN_uc010qit.1_Missense_Mutation_p.R628C|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	922						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TCGCTTGGAACGTACTCCTGT	0.413													15	63					0	0	0	0	T	69948722	T	T	69948722	3	4	7	1	0	0	0	0	1	0	0	0	10151	536	19	1	2810	1	MYPN	10	69948722	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	6096492	69948722	65586025	55	1840											
ZCCHC24	219654	broad.mit.edu	37	chr10	81154151	81154151	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttgtactcgccgaagcagcGctttttgccctggtatggag	6	12	12	11	3	0	0	0	0	0	0	1	2	0	1	2	2	4	4	2	2	3	5			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:81154151G>A	uc001kak.2	-	3	680	c.493C>T	c.(493-495)CGC>TGC	p.R165C	ZCCHC24_uc010qlr.1_Missense_Mutation_p.A105V|ZCCHC24_uc009xrw.2_RNA	NM_153367	NP_699198	Q8N2G6	ZCH24_HUMAN	zinc finger, CCHC domain containing 24	165							nucleic acid binding|zinc ion binding			breast(1)	1						CCGAAGCAGCGCTTTTTGCCC	0.567													42	174					0	0	0	0	A	81154151	A	A	81154151	3	1	7	1	0	0	0	0	1	0	0	0	17655	1087	38	1	240	1	ZCCHC24	10	81154151	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	11205429	81154151	54380596	56	1841											
ZNF518A	9849	broad.mit.edu	37	chr10	97917661	97917661	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagggaaagcaagttcaGaaaaagaaatgactttgata	18	10	9	4	0	2	4	2	2	0	2	2	5	2	5	0	1	1	2	0	1	6	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:97917661G>T	uc001klp.2	+	6	2439	c.1582G>T	c.(1582-1584)GAA>TAA	p.E528*	ZNF518A_uc001klo.1_5'UTR|ZNF518A_uc001klq.2_Nonsense_Mutation_p.E528*|ZNF518A_uc001klr.2_Nonsense_Mutation_p.E528*	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	528					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AGCAAGTTCAGAAAAAGAAAT	0.323													36	223					4.65686e-17	5.35745e-17	1	0	T	97917661	T	T	97917661	4	4	7	1	0	0	0	0	0	1	0	0	18029	943	33	2	1584	2	ZNF518A	10	97917661	Nonsense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	16763510	97917661	37617086	57	1842											
HMX3	340784	broad.mit.edu	37	chr10	124896943	124896943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctatctgagcagctcggagcGagccggcctggccgcgtccc	5	6	14	16	5	1	1	0	1	1	0	3	3	2	2	4	3	4	2	4	3	1	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr10:124896943G>A	uc010quc.1	+	2	770	c.770G>A	c.(769-771)CGA>CAA	p.R257Q		NM_001105574	NP_001099044	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	257	Homeobox.				cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		AGCTCGGAGCGAGCCGGCCTG	0.647													12	65					0	0	0	0	A	124896943	A	A	124896943	3	1	7	1	0	0	0	0	1	0	0	0	7287	1058	37	1	776	1	HMX3	10	124896943	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	26979282	124896943	10637804	58	1843											
PPFIBP2	8495	broad.mit.edu	37	chr11	7670058	7670058	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaattaagcacccactccacAggaagaagcttgttttagca	14	9	8	10	0	0	1	0	0	0	1	1	3	1	2	2	1	3	4	2	1	5	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:7670058A>T	uc001mfj.3	+	19	2213	c.1825A>T	c.(1825-1827)AGG>TGG	p.R609W	PPFIBP2_uc010rbb.1_Missense_Mutation_p.R532W|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_Missense_Mutation_p.R543W|PPFIBP2_uc010rbe.1_Missense_Mutation_p.R497W|PPFIBP2_uc001mfl.3_Missense_Mutation_p.R466W|PPFIBP2_uc009yfj.1_Missense_Mutation_p.R253W	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	609	SAM 1.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CCCACTCCACAGGAAGAAGCT	0.448													57	233					0	0	0	0	T	7670058	T	T	7670058	3	4	7	1	0	0	0	0	1	0	0	0	12369	179	7	5	1895	5	PPFIBP2	11	7670058	Missense_Mutation	SNP	A	TCGA-BA-5151-01A-01D-1434-08		7670058	127336458	59	1844											
ELP4	26610	broad.mit.edu	37	chr11	31671745	31671745	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaagacttagcttttaaattAaaaaggaagctattcaccat	18	12	5	6	0	1	1	1	0	0	1	1	2	1	2	1	1	2	2	1	1	9	6			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:31671745A>G	uc001mtb.2	+	9	1154	c.1119A>G	c.(1117-1119)TTA>TTG	p.L373L	ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Silent_p.L373L|ELP4_uc010rdz.1_Silent_p.L374L	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	373					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					CTTTTAAATTAAAAAGGAAGC	0.259													16	69					0	0	0	0	G	31671745	G	G	31671745	2	3	7	1	0	0	0	0	0	0	0	1	5106	359	13	5		5	ELP4	11	31671745	Silent	SNP	A	TCGA-BA-5151-01A-01D-1434-08	24001687	31671745	103334771	60	1845											
LRP4	4038	broad.mit.edu	37	chr11	46903411	46903411	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaggcatccatgccagctcGttcaatcttggggctcgcac	7	10	11	13	2	2	1	1	1	1	0	5	1	3	1	2	3	2	5	2	3	1	2			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:46903411G>A	uc001ndn.3	-	20	2802	c.2656C>T	c.(2656-2658)CGA>TGA	p.R886*		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	886	Extracellular (Potential).|LDL-receptor class B 8.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		ATGCCAGCTCGTTCAATCTTG	0.507													25	85					0	0	0	0	A	46903411	A	A	46903411	4	1	7	1	0	0	0	0	0	1	0	0	9009	1153	40	1	3137	1	LRP4	11	46903411	Nonsense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	15231666	46903411	88103105	61	1846											
KDELC2	143888	broad.mit.edu	37	chr11	108350193	108350193	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggatatctgtaagcagccacGgtcccatccacatttacttg	10	11	8	12	1	1	0	0	0	1	0	3	1	3	1	3	2	3	2	3	2	3	5			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr11:108350193G>T	uc001pkj.2	-	6	1194	c.1128C>A	c.(1126-1128)ACC>ACA	p.T376T	KDELC2_uc001pki.2_Silent_p.T320T	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	376						endoplasmic reticulum lumen		p.T376T(1)		ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		AAGCAGCCACGGTCCCATCCA	0.408													13	72					2.39187e-15	2.70386e-15	1	0	T	108350193	T	T	108350193	2	4	7	1	0	0	0	0	0	0	0	1	8157	1103	39	3		3	KDELC2	11	108350193	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	61446782	108350193	26656323	62	1847											
GLI1	2735	broad.mit.edu	37	chr12	57862003	57862003	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	actgactgtgccagagggtgCcatggtgagagagcccaggc	9	6	16	10	0	0	4	0	2	0	2	0	5	0	4	3	3	3	0	3	3	0	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:57862003C>T	uc001snx.2	+	10	1382	c.1304C>T	c.(1303-1305)GCC>GTC	p.A435V	GLI1_uc009zpq.2_Missense_Mutation_p.A307V	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	435					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CCAGAGGGTGCCATGGTGAGA	0.582													3	57					0	0	0	0	T	57862003	T	T	57862003	3	4	7	1	0	0	0	0	1	0	0	0	6474	739	26	4	1338	4	GLI1	12	57862003	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08		57862003	75989892	63	1848											
KIF5A	3798	broad.mit.edu	37	chr12	57968982	57968982	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccggcagctggagaaccTccaggtggagtgtcaccgca	8	6	15	12	2	1	1	1	0	0	1	2	3	2	2	4	4	3	3	4	4	1	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:57968982T>C	uc001sor.1	+	16	2040	c.1832T>C	c.(1831-1833)CTC>CCC	p.L611P	KIF5A_uc010srr.1_Missense_Mutation_p.L522P	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	611					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						CTGGAGAACCTCCAGGTGGAG	0.562													10	40					0	0	0	0	C	57968982	C	C	57968982	3	2	7	1	0	0	0	0	1	0	0	0	8344	1551	54	5	1894	5	KIF5A	12	57968982	Missense_Mutation	SNP	T	TCGA-BA-5151-01A-01D-1434-08	106979	57968982	75882913	64	1849											
KNTC1	9735	broad.mit.edu	37	chr12	123103082	123103082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgttctgagagtctcatcGctgtcctcgagtaagcaaaa	11	12	9	9	2	2	1	1	1	2	1	6	3	3	1	1	0	1	4	1	0	3	3			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:123103082G>A	uc001ucv.2	+	59	6302	c.6139G>A	c.(6139-6141)GCT>ACT	p.A2047T	KNTC1_uc010taf.1_Missense_Mutation_p.A972T	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	2047					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GAGTCTCATCGCTGTCCTCGA	0.338													19	57					0	0	0	0	A	123103082	A	A	123103082	3	1	7	1	0	0	0	0	1	0	0	0	8467	1087	38	1	6369	1	KNTC1	12	123103082	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	65134100	123103082	10748813	65	1850											
FAM101A	144347	broad.mit.edu	37	chr12	124798975	124798975	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttccggaccaccctgcactgCagcctgggccggcccagccg	5	5	12	19	3	0	0	0	0	0	0	1	1	1	1	7	3	4	2	7	3	0	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:124798975C>A	uc001ugd.1	+	3	555	c.312C>A	c.(310-312)TGC>TGA	p.C104*	FAM101A_uc001uge.1_Nonsense_Mutation_p.C104*	NM_181709	NP_859060	Q6ZTI6	F101A_HUMAN	hypothetical protein LOC144347	185											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		CCCTGCACTGCAGCCTGGGCC	0.706													11	45					0.000673444	0.000717604	1	0	A	124798975	A	A	124798975	4	1	7	1	0	0	0	0	0	1	0	0	5408	718	25	4	318	4	FAM101A	12	124798975	Nonsense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	1695893	124798975	9052920	66	1851											
RIMBP2	23504	broad.mit.edu	37	chr12	130921701	130921701	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caccaggagctcggggggaaCggcagcaactgcagagtcca	11	3	15	12	2	0	1	0	0	0	1	2	3	1	3	2	5	5	4	2	5	2	0	rs139344487	byFrequency	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr12:130921701C>T	uc001uil.2	-	10	1905	c.1741G>A	c.(1741-1743)GTT>ATT	p.V581I	RIMBP2_uc001uim.2_Missense_Mutation_p.V489I|RIMBP2_uc001uin.1_Missense_Mutation_p.V240I	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	581						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCGGGGGGAACGGCAGCAACT	0.662													7	8					0	0	0	0	T	130921701	T	T	130921701	3	4	7	1	0	0	0	0	1	0	0	0	13428	536	19	1	1457	1	RIMBP2	12	130921701	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	6122726	130921701	2930194	67	1852											
RCBTB2	1102	broad.mit.edu	37	chr13	49076887	49076887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaggcgccacgtgacggCgggcgtggcaaagcaggcaa	10	2	19	10	5	0	1	0	1	0	0	0	3	0	2	1	6	1	3	1	6	2	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr13:49076887C>T	uc001vch.2	-	11	1461	c.1090G>A	c.(1090-1092)GCC>ACC	p.A364T	RCBTB2_uc010tgg.1_Missense_Mutation_p.A369T|RCBTB2_uc001vci.2_Missense_Mutation_p.A340T|RCBTB2_uc010tgh.1_Missense_Mutation_p.A90T|RCBTB2_uc001vcj.2_Missense_Mutation_p.A316T|RCBTB2_uc010acv.1_RNA|RCBTB2_uc010tgi.1_3'UTR	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	364	RCC1 6.						Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		CACGTGACGGCGGGCGTGGCA	0.592													27	119					0	0	0	0	T	49076887	T	T	49076887	3	4	7	1	0	0	0	0	1	0	0	0	13237	768	27	1	585	1	RCBTB2	13	49076887	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08		49076887	66092991	68	1853											
DOCK9	23348	broad.mit.edu	37	chr13	99554563	99554563	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcttcggatactgcatggcGgcttcatgaaggatgccctt	7	12	12	10	2	1	1	1	1	0	0	2	3	1	3	1	4	4	3	1	4	2	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr13:99554563G>A	uc001vnt.2	-	12	1417	c.1362C>T	c.(1360-1362)GCC>GCT	p.A454A	DOCK9_uc001vnw.2_Silent_p.A453A|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.A454A|DOCK9_uc010tis.1_Silent_p.A453A|DOCK9_uc010tit.1_Silent_p.A454A|DOCK9_uc010afu.1_Silent_p.A269A	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	454					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACTGCATGGCGGCTTCATGAA	0.532													15	49					0	0	0	0	A	99554563	A	A	99554563	2	1	7	1	0	0	0	0	0	0	0	1	4716	1103	39	1		1	DOCK9	13	99554563	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	50477676	99554563	15615315	69	1854											
RAB2B	84932	broad.mit.edu	37	chr14	21936559	21936559	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaccatgttggaactagagtGctgccgggcatcctctaacc	10	9	10	12	1	1	1	0	0	1	1	2	2	2	2	4	2	5	3	4	2	4	3			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr14:21936559G>A	uc010tlt.1	-	5	420	c.319C>T	c.(319-321)CAC>TAC	p.H107Y	RAB2B_uc010tls.1_Missense_Mutation_p.H61Y|RAB2B_uc001wax.2_Missense_Mutation_p.H42Y|RAB2B_uc010ain.2_Intron	NM_032846	NP_116235	Q8WUD1	RAB2B_HUMAN	RAB2B protein isoform 1	107					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			ovary(1)	1	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		GAACTAGAGTGCTGCCGGGCA	0.423													10	49					0	0	0	0	A	21936559	A	A	21936559	3	1	7	1	0	0	0	0	1	0	0	0	12983	1319	46	4	347	4	RAB2B	14	21936559	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08		21936559	85412981	70	1855											
TTC7B	145567	broad.mit.edu	37	chr14	91142993	91142993	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtatcctgctcagcacagcGtcccggttggcctgaaaaaa	10	8	11	12	2	1	1	1	1	0	0	3	1	3	1	3	3	3	4	3	3	4	2	rs149388931		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr14:91142993G>A	uc001xyp.2	-	9	1148	c.1026C>T	c.(1024-1026)GAC>GAT	p.D342D	TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	342							binding			ovary(2)	2		Melanoma(154;0.222)				TCAGCACAGCGTCCCGGTTGG	0.532													17	98					0	0	0	0	A	91142993	A	A	91142993	2	1	7	1	0	0	0	0	0	0	0	1	16781	1136	40	1		1	TTC7B	14	91142993	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	69206434	91142993	16206547	71	1856											
RASGRP1	10125	broad.mit.edu	37	chr15	38808519	38808519	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtatttgattttatccttTgagtaagtttcctggaccag	8	18	9	6	0	0	2	0	2	0	0	2	3	2	3	3	2	0	3	3	2	3	7			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:38808519T>C	uc001zke.3	-	6	732	c.554A>G	c.(553-555)CAA>CGA	p.Q185R	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Missense_Mutation_p.Q47R|RASGRP1_uc010bbg.2_Missense_Mutation_p.Q47R|RASGRP1_uc001zkd.3_Missense_Mutation_p.Q185R	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	185					cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TTTTATCCTTTGAGTAAGTTT	0.443													19	111					0	0	0	0	C	38808519	C	C	38808519	3	2	7	1	0	0	0	0	1	0	0	0	13139	1812	63	5	1887	5	RASGRP1	15	38808519	Missense_Mutation	SNP	T	TCGA-BA-5151-01A-01D-1434-08		38808519	63722873	72	1857											
VPS13C	54832	broad.mit.edu	37	chr15	62299547	62299547	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttctgagactttagactgtGttaacttgtttttgtaggca	8	18	9	6	0	1	2	0	1	1	2	1	3	1	2	0	1	1	4	0	1	3	8			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:62299547G>A	uc002agz.2	-	15	1324	c.1250C>T	c.(1249-1251)ACA>ATA	p.T417I	VPS13C_uc002aha.2_Missense_Mutation_p.T374I|VPS13C_uc002ahb.1_Missense_Mutation_p.T417I|VPS13C_uc002ahc.1_Missense_Mutation_p.T374I	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	417					protein localization					ovary(2)	2						TTTAGACTGTGTTAACTTGTT	0.313													11	73					0	0	0	0	A	62299547	A	A	62299547	3	1	7	1	0	0	0	0	1	0	0	0	17259	1377	48	4	10323	4	VPS13C	15	62299547	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	23491028	62299547	40231845	73	1858											
MAP2K1	5604	broad.mit.edu	37	chr15	66727455	66727455	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggcctttcttacccagaaGcagaaggtgggagaactgaa	13	7	13	8	0	1	4	0	1	1	3	1	6	1	4	2	3	3	1	2	3	5	2			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:66727455G>T	uc010bhq.2	+	2	646	c.171G>T	c.(169-171)AAG>AAT	p.K57N	MAP2K1_uc010ujp.1_Missense_Mutation_p.K35N	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	57					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						TTACCCAGAAGCAGAAGGTGG	0.542									Cardiofaciocutaneous_syndrome				47	286					4.18559e-23	4.90204e-23	1	0	T	66727455	T	T	66727455	3	4	7	1	0	0	0	0	1	0	0	0	9289	962	34	4	177	4	MAP2K1	15	66727455	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	4427908	66727455	35803937	74	1859											
PLIN1	5346	broad.mit.edu	37	chr15	90213327	90213327	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagtgttggcagcaaattccGcagtgtctctggccaccccc	7	9	11	14	1	1	0	0	0	1	0	3	1	2	0	4	2	1	4	4	2	1	2			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:90213327G>A	uc010upx.1	-	5	592	c.482C>T	c.(481-483)GCG>GTG	p.A161V	PLIN1_uc002boh.2_Missense_Mutation_p.A161V	NM_001145311	NP_001138783	O60240	PLIN1_HUMAN	perilipin 1	161					triglyceride catabolic process	lipid particle	lipid binding			central_nervous_system(1)|skin(1)	2						AGCAAATTCCGCAGTGTCTCT	0.627													9	37					0	0	0	0	A	90213327	A	A	90213327	3	1	7	1	0	0	0	0	1	0	0	0	12144	1087	38	1	1106	1	PLIN1	15	90213327	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	23485872	90213327	12318065	75	1860											
OR4F15	390649	broad.mit.edu	37	chr15	102358822	102358822	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagaatgtgtctatactttTtagccacttcctctatcatt	10	17	4	10	0	3	1	1	0	2	1	4	1	4	1	2	0	2	0	2	0	6	8			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr15:102358822T>C	uc010uts.1	+	1	433	c.433T>C	c.(433-435)TTA>CTA	p.L145L		NM_001001674	NP_001001674	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TCTATACTTTTTAGCCACTTC	0.408													36	241					0	0	0	0	C	102358822	C	C	102358822	2	2	7	1	0	0	0	0	0	0	0	1	11115	1838	64	5		5	OR4F15	15	102358822	Silent	SNP	T	TCGA-BA-5151-01A-01D-1434-08	12145495	102358822	172570	76	1861											
TAOK2	9344	broad.mit.edu	37	chr16	29990752	29990752	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctaggatggcacccgaggTgatcctggccatggatgagg	8	8	15	10	1	0	2	0	2	0	0	2	5	2	4	4	6	0	1	4	6	1	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:29990752T>G	uc002dva.1	+	8	1361	c.578T>G	c.(577-579)GTG>GGG	p.V193G	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.V193G|TAOK2_uc002dvc.1_Missense_Mutation_p.V193G|TAOK2_uc010bzm.1_Missense_Mutation_p.V193G|TAOK2_uc002dvd.1_5'Flank	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	193	Protein kinase.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GCACCCGAGGTGATCCTGGCC	0.582													5	37					0	0	0	0	G	29990752	G	G	29990752	3	3	7	1	0	0	0	0	1	0	0	0	15614	1696	59	5	604	5	TAOK2	16	29990752	Missense_Mutation	SNP	T	TCGA-BA-5151-01A-01D-1434-08		29990752	60364001	77	1862											
ITGAL	3683	broad.mit.edu	37	chr16	30510407	30510407	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctgcagctcccggcccgtGgtggatatggtcaccctgat	5	9	12	15	2	1	1	1	1	0	0	2	2	2	2	4	4	2	2	4	4	1	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:30510407G>A	uc002dyi.3	+	16	2021	c.1845G>A	c.(1843-1845)GTG>GTA	p.V615V	ITGAL_uc002dyj.3_Silent_p.V532V|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	615	FG-GAP 7.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	CCCGGCCCGTGGTGGATATGG	0.567													11	49					0	0	0	0	A	30510407	A	A	30510407	2	1	7	1	0	0	0	0	0	0	0	1	7925	1335	47	4		4	ITGAL	16	30510407	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	519655	30510407	59844346	78	1863											
ABCC12	94160	broad.mit.edu	37	chr16	48149471	48149471	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacggtcggagtagacagcgCgggccaggctaatcctctgc	8	6	15	12	4	1	1	0	0	1	1	3	3	2	2	2	4	2	2	2	4	2	2			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:48149471C>T	uc002efc.1	-	13	2190	c.1844G>A	c.(1843-1845)CGC>CAC	p.R615H	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	615	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				GTAGACAGCGCGGGCCAGGCT	0.632													21	61					0	0	0	0	T	48149471	T	T	48149471	3	4	7	1	0	0	0	0	1	0	0	0	52	768	27	1	2303	1	ABCC12	16	48149471	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	17639064	48149471	42205282	79	1864											
FHOD1	29109	broad.mit.edu	37	chr16	67272317	67272317	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgagaagagggagcggCggagctcaggaccactggag	11	4	18	8	2	2	2	2	1	0	2	2	7	2	6	1	5	2	1	1	5	1	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:67272317C>T	uc002esl.2	-	4	519	c.407G>A	c.(406-408)CGC>CAC	p.R136H	FHOD1_uc010ced.2_5'UTR|FHOD1_uc010vjh.1_5'UTR	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	136	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GAGGGAGCGGCGGAGCTCAGG	0.542													13	39					0	0	0	0	T	67272317	T	T	67272317	3	4	7	1	0	0	0	0	1	0	0	0	5914	768	27	1	3163	1	FHOD1	16	67272317	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	19122846	67272317	23082436	80	1865											
CTCF	10664	broad.mit.edu	37	chr16	67645241	67645242	+	Frame_Shift_Ins	INS	-	G	G																															gggtttcaggtggttaaagtINSgggggccaatggagaggtgg																										TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:67645241_67645242insG	uc002etl.2	+	3	796_797	c.506_507insG	c.(505-507)GTGfs	p.V169fs	CTCF_uc010cek.2_Intron	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	169					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		GTGGTTAAAGTGGGGGCCAATG	0.505													---	---	---								G	67645242	G	G	67645241	7	5	7	1	0	1	1	0	0	0	0	0	4017	1696	59	0	508	0	CTCF	16	67645241	Frame_Shift_Ins	INS	-	TCGA-BA-5151-01A-01D-1434-08	372924	67645241	22709512	81	1866											
C16orf48	84080	broad.mit.edu	37	chr16	67700071	67700071	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaggatctctccggcaccGggaccgatgcaggggccacg	7	5	14	15	4	1	0	0	0	1	0	4	3	3	2	5	5	1	2	5	5	0	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr16:67700071G>A	uc002etw.1	-	2	466	c.183C>T	c.(181-183)CCC>CCT	p.P61P	C16orf48_uc002etv.1_5'Flank|C16orf48_uc010cem.1_Silent_p.P61P|C16orf86_uc002etx.1_5'Flank|C16orf86_uc002ety.2_5'Flank|C16orf86_uc002etz.2_5'Flank	NM_032140	NP_115516	Q9H0I2	CP048_HUMAN	hypothetical protein LOC84080	61						microtubule cytoskeleton	protein binding				0		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CTCCGGCACCGGGACCGATGC	0.682													30	110					0	0	0	0	A	67700071	A	A	67700071	2	1	7	1	0	0	0	0	0	0	0	1	1822	1103	39	1		1	C16orf48	16	67700071	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	54830	67700071	22654682	82	1867											
DLG4	1742	broad.mit.edu	37	chr17	7099547	7099547	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagcctctgacctgatgtaGaaaccccttttggggttgct	8	12	11	10	0	1	3	0	2	1	1	1	4	1	3	4	2	3	3	4	2	3	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:7099547G>A	uc002get.3	-	13	2623	c.1422C>T	c.(1420-1422)TTC>TTT	p.F474F	DLG4_uc010vtm.1_RNA|DLG4_uc010vtn.1_Silent_p.F371F|DLG4_uc010cly.2_Silent_p.F428F|DLG4_uc010vto.1_Silent_p.F471F	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	431	SH3.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						ACCTGATGTAGAAACCCCTTT	0.642													5	85					0	0	0	0	A	7099547	A	A	7099547	2	1	7	1	0	0	0	0	0	0	0	1	4579	933	33	2		2	DLG4	17	7099547	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08		7099547	74095663	83	1868											
TP53	7157	broad.mit.edu	37	chr17	7578503	7578503	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatcaacccacagctgcaCagggcaggtcttggccagtt	10	7	12	12	0	2	0	1	0	1	0	2	1	2	1	2	4	3	4	2	4	2	2			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:7578503C>T	uc002gim.2	-	5	621	c.427G>A	c.(427-429)GTG>ATG	p.V143M	TP53_uc002gig.1_Missense_Mutation_p.V143M|TP53_uc002gih.2_Missense_Mutation_p.V143M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V11M|TP53_uc010cng.1_Missense_Mutation_p.V11M|TP53_uc002gii.1_Missense_Mutation_p.V11M|TP53_uc010cnh.1_Missense_Mutation_p.V143M|TP53_uc010cni.1_Missense_Mutation_p.V143M|TP53_uc002gij.2_Missense_Mutation_p.V143M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V50M|TP53_uc002gio.2_Missense_Mutation_p.V11M|TP53_uc010vug.1_Missense_Mutation_p.V104M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	143	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius).|V -> E (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V143M(16)|p.V143A(14)|p.0?(7)|p.V143E(4)|p.V143L(4)|p.V143V(2)|p.V143fs*27(2)|p.L137_W146del10(1)|p.V143fs*29(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.A138_V143delAKTCPV(1)|p.V143G(1)|p.V143_S149del(1)|p.C141fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACAGCTGCACAGGGCAGGTC	0.587		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			27	47					0	0	0	0	T	7578503	T	T	7578503	3	4	7	1	0	0	0	0	1	0	0	0	16448	478	17	4	871	4	TP53	17	7578503	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	478956	7578503	73616707	84	1869											
STAC2	342667	broad.mit.edu	37	chr17	37368614	37368614	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgacgcggatgaagccGtcagcatccttgcttctgcc	6	10	11	14	3	2	2	1	2	1	0	3	3	3	3	3	1	5	3	3	1	1	2	rs147042988		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:37368614G>A	uc002hrs.2	-	11	1386	c.1167C>T	c.(1165-1167)GAC>GAT	p.D389D	STAC2_uc010cvt.2_Silent_p.D247D	NM_198993	NP_945344	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	389					intracellular signal transduction		metal ion binding			pancreas(1)	1						GGATGAAGCCGTCAGCATCCT	0.637													5	33					0	0	0	0	A	37368614	A	A	37368614	2	1	7	1	0	0	0	0	0	0	0	1	15306	1136	40	1		1	STAC2	17	37368614	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	29790111	37368614	43826596	85	1870											
STAT3	6774	broad.mit.edu	37	chr17	40474419	40474419	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaccaggatattggtagcaTccatgatcttatagcccatg	12	11	8	10	0	1	1	0	1	1	0	2	2	2	2	3	2	2	2	3	2	4	5			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:40474419T>A	uc002hzl.1	-	21	2222	c.1982A>T	c.(1981-1983)GAT>GTT	p.D661V	STAT3_uc002hzk.1_Missense_Mutation_p.D661V|STAT3_uc002hzm.1_Missense_Mutation_p.D661V|STAT3_uc010wgh.1_Missense_Mutation_p.D563V|STAT3_uc002hzn.1_Missense_Mutation_p.D661V	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	661	SH2.				cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		ATTGGTAGCATCCATGATCTT	0.483									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				59	230					0	0	0	0	A	40474419	A	A	40474419	3	1	7	1	0	0	0	0	1	0	0	0	15332	1435	50	5	346	5	STAT3	17	40474419	Missense_Mutation	SNP	T	TCGA-BA-5151-01A-01D-1434-08	3105805	40474419	40720791	86	1871											
ITGB3	3690	broad.mit.edu	37	chr17	45367599	45367599	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagttggggttctgtccatgGattccagcaatgtcctccag	7	12	11	11	0	1	0	0	0	1	0	5	1	5	1	4	3	1	3	4	3	1	3	rs150029332	byFrequency	TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:45367599G>T	uc002ilj.2	+	8	1104	c.1084G>T	c.(1084-1086)GAT>TAT	p.D362Y	ITGB3_uc002ili.1_Missense_Mutation_p.D362Y|ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	362	VWFA.|Extracellular (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	TCTGTCCATGGATTCCAGCAA	0.493													49	205					1.11015e-26	1.32403e-26	1	0	T	45367599	T	T	45367599	3	4	7	1	0	0	0	0	1	0	0	0	7934	1174	41	2	1114	2	ITGB3	17	45367599	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	4893180	45367599	35827611	87	1872											
WFIKKN2	124857	broad.mit.edu	37	chr17	48913362	48913362	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtggcagcgctgctgctgCtgctgctactgctcggggtg	3	10	17	11	2	0	0	0	0	0	0	1	0	0	0	0	4	8	8	0	4	1	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:48913362C>G	uc002isv.3	+	1	758	c.64C>G	c.(64-66)CTG>GTG	p.L22V	WFIKKN2_uc010dbu.2_Intron	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	22						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			gctgctgctgctgctgctact	0.602													2	13					0	0	0	0	G	48913362	G	G	48913362	3	3	7	1	0	0	0	0	1	0	0	0	17427	796	28	4	66	4	WFIKKN2	17	48913362	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	3545763	48913362	32281848	88	1873											
RPTOR	57521	broad.mit.edu	37	chr17	78899184	78899184	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagactgcggacgacgcGgacgatgctgctggacacaa	11	5	14	11	5	0	2	0	1	0	1	0	7	0	5	0	3	3	2	0	3	2	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr17:78899184G>A	uc002jyt.1	+	24	3628	c.2823G>A	c.(2821-2823)GCG>GCA	p.A941A	RPTOR_uc010wug.1_Silent_p.A783A	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	941					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CGGACGACGCGGACGATGCTG	0.572													14	65					0	0	0	0	A	78899184	A	A	78899184	2	1	7	1	0	0	0	0	0	0	0	1	13730	1103	39	1		1	RPTOR	17	78899184	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	29985822	78899184	2296026	89	1874											
ANKRD12	23253	broad.mit.edu	37	chr18	9204522	9204522	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggggggagagacttatatCttcttacaggacatactcag	11	12	11	7	0	3	1	1	0	2	1	3	4	3	3	0	4	2	0	0	4	4	6			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr18:9204522C>G	uc002knv.2	+	4	541	c.284C>G	c.(283-285)TCT>TGT	p.S95C	ANKRD12_uc010wzn.1_Missense_Mutation_p.S95C|ANKRD12_uc002knw.2_Intron|ANKRD12_uc002knx.2_Intron	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	95						nucleus				ovary(2)|central_nervous_system(1)	3						AGACTTATATCTTCTTACAGG	0.373													41	126					0	0	0	0	G	9204522	G	G	9204522	3	3	7	1	0	0	0	0	1	0	0	0	640	913	32	2	294	2	ANKRD12	18	9204522	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08		9204522	68872726	90	1875											
MUC16	94025	broad.mit.edu	37	chr19	9088876	9088876	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgaaacagtggttgttgctGaaggtaaccctgtcttgaat	10	14	11	6	0	1	3	0	3	1	0	1	3	1	3	1	2	3	4	1	2	4	5			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:9088876G>A	uc002mkp.2	-	1	3143	c.2939C>T	c.(2938-2940)TCA>TTA	p.S980L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	980	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTTGTTGCTGAAGGTAACCC	0.458													86	307					0	0	0	0	A	9088876	A	A	9088876	3	1	7	1	0	0	0	0	1	0	0	0	10026	1294	45	2	40920	2	MUC16	19	9088876	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08		9088876	50040107	91	1876											
SMARCA4	6597	broad.mit.edu	37	chr19	11132522	11132522	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgctgctgacgggcacacCgctgcagaacaagcttcccg	8	6	11	16	3	0	2	0	1	0	1	1	2	1	2	3	1	5	6	3	1	2	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:11132522C>T	uc002mqf.3	+	19	3022	c.2738C>T	c.(2737-2739)CCG>CTG	p.P913L	SMARCA4_uc010dxp.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxo.2_Missense_Mutation_p.P913L|SMARCA4_uc002mqg.1_Missense_Mutation_p.P913L|SMARCA4_uc010dxq.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxr.2_Missense_Mutation_p.P913L|SMARCA4_uc002mqj.3_Missense_Mutation_p.P913L|SMARCA4_uc010dxs.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxt.1_Missense_Mutation_p.P133L|SMARCA4_uc002mqh.3_Missense_Mutation_p.P36L|SMARCA4_uc002mqi.1_Missense_Mutation_p.P116L	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	913	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ACGGGCACACCGCTGCAGAAC	0.612			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				8	44					0	0	0	0	T	11132522	T	T	11132522	3	4	7	1	0	0	0	0	1	0	0	0	14834	652	23	1	2808	1	SMARCA4	19	11132522	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	2043646	11132522	47996461	92	1877											
MLL4	9757	broad.mit.edu	37	chr19	36214909	36214909	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcggaccccccgagaaaatgGtgcgaactgcttaatgcttt	10	10	10	11	3	0	1	0	0	0	1	1	4	0	2	3	2	4	2	3	2	4	2			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:36214909G>T	uc010eei.2	+	9	3334	c.3334_splice	c.e9+1	p.E1112_splice		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4						chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGAGAAAATGGTGCGAACTGC	0.552													5	41					2.0095e-06	2.15896e-06	1	0	T	36214909	T	T	36214909	5	4	7	1	0	0	0	0	0	0	1	0	9676	1275	44	4	3365	4	MLL4	19	36214909	Splice_Site	SNP	G	TCGA-BA-5151-01A-01D-1434-08	25082387	36214909	22914074	93	1878											
RYR1	6261	broad.mit.edu	37	chr19	38939326	38939326	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccccaagcgggatgtggaggGcatgggcccccctgagatca	8	5	15	13	1	1	1	1	1	0	1	1	4	1	3	5	4	1	1	5	4	1	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:38939326G>A	uc002oit.2	+	11	1125	c.995G>A	c.(994-996)GGC>GAC	p.G332D	RYR1_uc002oiu.2_Missense_Mutation_p.G332D	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	332	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GATGTGGAGGGCATGGGCCCC	0.637													41	164					0	0	0	0	A	38939326	A	A	38939326	3	1	7	1	0	0	0	0	1	0	0	0	13833	1203	42	4	1037	4	RYR1	19	38939326	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	2724417	38939326	20189657	94	1879											
ZNF610	162963	broad.mit.edu	37	chr19	52856994	52856994	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggaggagtggaaatccctGgaccctggacagagggcttt	10	7	15	9	0	0	1	0	0	0	1	1	6	1	6	2	6	0	1	2	6	1	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:52856994G>C	uc002pyx.3	+	4	529	c.123G>C	c.(121-123)CTG>CTC	p.L41L	ZNF610_uc002pyy.3_Silent_p.L41L|ZNF610_uc002pyz.3_Silent_p.L41L|ZNF610_uc002pza.2_Silent_p.L41L	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GGAAATCCCTGGACCCTGGAC	0.493													32	140					0	0	0	0	C	52856994	C	C	52856994	2	2	7	1	0	0	0	0	0	0	0	1	18103	1335	47	4		4	ZNF610	19	52856994	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08	13917668	52856994	6271989	95	1880											
NLRP12	91662	broad.mit.edu	37	chr19	54327166	54327166	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaggtcctctctctgtcctCtctcccacaggtccttcctg	3	13	6	19	0	3	0	0	0	3	0	10	0	8	0	6	2	0	0	6	2	0	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:54327166C>G	uc002qch.3	-	1	483	c.263G>C	c.(262-264)AGA>ACA	p.R88T	NLRP12_uc002qci.3_Missense_Mutation_p.R88T|NLRP12_uc002qcj.3_Missense_Mutation_p.R88T|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.R88T	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	88	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TCTCTGTCCTCTCTCCCACAG	0.488													65	224					0	0	0	0	G	54327166	G	G	54327166	3	3	7	1	0	0	0	0	1	0	0	0	10528	913	32	2	3058	2	NLRP12	19	54327166	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08	1470172	54327166	4801817	96	1881											
LILRA6	79168	broad.mit.edu	37	chr19	54745723	54745723	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggccaccacagggctgggCagggctgagagggtgggttt	7	6	20	8	0	0	1	0	1	0	1	0	3	0	1	2	6	0	4	2	6	0	1			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr19:54745723C>A	uc002qeu.1	-	4	511	c.387G>T	c.(385-387)CTG>CTT	p.L129L	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Silent_p.L129L|LILRA6_uc002qek.1_Silent_p.L129L|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Silent_p.L129L|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Silent_p.L129L|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Silent_p.L129L|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Silent_p.L129L|LILRA6_uc010yep.1_Silent_p.L129L|LILRA6_uc010yeq.1_Silent_p.L129L|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_5'UTR	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	129	Extracellular (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGGGCTGGGCAGGGCTGAGA	0.562													16	412					2.4624e-09	2.736e-09	1	0	A	54745723	A	A	54745723	2	1	7	1	0	0	0	0	0	0	0	1	8830	697	25	4		4	LILRA6	19	54745723	Silent	SNP	C	TCGA-BA-5151-01A-01D-1434-08	418557	54745723	4383260	97	1882											
BTBD3	22903	broad.mit.edu	37	chr20	11903288	11903288	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgctttttacagatatatCtattgtgatgaaattgactt	11	19	7	4	0	1	4	0	3	1	1	1	4	1	4	0	0	2	1	0	0	5	9			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr20:11903288C>G	uc002wnz.2	+	4	902	c.543C>G	c.(541-543)ATC>ATG	p.I181M	BTBD3_uc002wny.2_Missense_Mutation_p.I120M|BTBD3_uc002woa.2_Missense_Mutation_p.I120M|BTBD3_uc010zrf.1_Missense_Mutation_p.I30M|BTBD3_uc010zrg.1_Missense_Mutation_p.I30M|BTBD3_uc010zrh.1_Missense_Mutation_p.I30M	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	181	BTB.									ovary(2)|central_nervous_system(1)	3						ACAGATATATCTATTGTGATG	0.388													27	132					0	0	0	0	G	11903288	G	G	11903288	3	3	7	1	0	0	0	0	1	0	0	0	1549	903	32	2	557	2	BTBD3	20	11903288	Missense_Mutation	SNP	C	TCGA-BA-5151-01A-01D-1434-08		11903288	51122232	98	1883											
KIAA0406	9675	broad.mit.edu	37	chr20	36631033	36631033	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagctgcgcactgaccttCaggcggatttgcagattttt	8	12	11	10	2	1	2	1	1	0	1	1	3	1	3	1	2	4	4	1	2	0	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr20:36631033C>T	uc002xhl.2	-	5	2858	c.2649G>A	c.(2647-2649)CTG>CTA	p.L883L	KIAA0406_uc002xhm.2_Silent_p.L883L	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	883							binding				0		Myeloproliferative disorder(115;0.00874)				CACTGACCTTCAGGCGGATTT	0.532													29	116					0	0	0	0	T	36631033	T	T	36631033	2	4	7	1	0	0	0	0	0	0	0	1	8212	813	29	2		2	KIAA0406	20	36631033	Silent	SNP	C	TCGA-BA-5151-01A-01D-1434-08	24727745	36631033	26394487	99	1884											
PTPRT	11122	broad.mit.edu	37	chr20	40743859	40743859	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttctggactgtgaaggtgcGtatgacgtattctgccaggg	7	12	14	8	2	2	2	0	2	2	0	2	3	2	3	1	3	2	2	1	3	3	4			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr20:40743859G>A	uc002xkg.2	-	22	3263	c.3079C>T	c.(3079-3081)CGC>TGC	p.R1027C	PTPRT_uc010ggj.2_Missense_Mutation_p.R1046C|PTPRT_uc010ggi.2_Missense_Mutation_p.R230C	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1027	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GTGAAGGTGCGTATGACGTAT	0.458													31	133					0	0	0	0	A	40743859	A	A	40743859	3	1	7	1	0	0	0	0	1	0	0	0	12877	1145	40	1	1286	1	PTPRT	20	40743859	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	4112826	40743859	22281661	100	1885											
ZNF512B	57473	broad.mit.edu	37	chr20	62602196	62602199	+	5'Flank	DEL	TTCC	-	-																															ttccttccttccttttctctTtccttccttctcttctcttc																										TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr20:62602196_62602199delTTCC	uc002yhl.1	-							NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					ccttttctctttccttccttctct	0													---	---	---								-	62602199	-	-	62602196	6	5	7	0	1	1	0	1	0	0	0	0	18024	1856	64	0		0	ZNF512B	20	62602196	5'Flank	DEL	TTCC	TCGA-BA-5151-01A-01D-1434-08	21858337	62602196	423324	101	1886											
CLDN17	26285	broad.mit.edu	37	chr21	31538657	31538657	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagatgccaataagcagggcGatcaaggagagagcaacagc	16	3	13	9	1	1	2	1	0	0	2	1	5	1	3	1	2	5	2	1	2	4	1	rs138854149		TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr21:31538657G>A	uc011acv.1	-	1	279	c.279C>T	c.(277-279)ATC>ATT	p.I93I		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	93	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2						TAAGCAGGGCGATCAAGGAGA	0.557													32	105					0	0	0	0	A	31538657	A	A	31538657	2	1	7	1	0	0	0	0	0	0	0	1	3493	1048	37	1		1	CLDN17	21	31538657	Silent	SNP	G	TCGA-BA-5151-01A-01D-1434-08		31538657	16591238	102	1887											
KRTAP10-4	386672	broad.mit.edu	37	chr21	45993723	45993723	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctccgactcctggcaggtgGacgactgcccagagagctgc	7	6	14	14	2	0	1	0	0	0	1	2	5	2	2	3	3	3	3	3	3	0	0			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chr21:45993723G>A	uc002zfk.1	+	1	118	c.88G>A	c.(88-90)GAC>AAC	p.D30N	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	30						keratin filament					0						CTGGCAGGTGGACGACTGCCC	0.682													27	99					0	0	0	0	A	45993723	A	A	45993723	3	1	7	1	0	0	0	0	1	0	0	0	8550	1174	41	2	90	2	KRTAP10-4	21	45993723	Missense_Mutation	SNP	G	TCGA-BA-5151-01A-01D-1434-08	14455066	45993723	2136172	103	1888											
KIAA1210	57481	broad.mit.edu	37	chrX	118217058	118217058	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgaacatctttttaggtTggttttcatttgcagagcca	10	16	9	6	0	2	2	1	1	1	1	2	2	2	2	1	2	3	3	1	2	3	7			TCGA-BA-5151-01A-01D-1434-08	TCGA-BA-5151-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac15d7e-3930-4fcb-b752-4a4f00449ddd	7e57b010-763c-4a96-bab3-1016647a1569	g.chrX:118217058T>C	uc004era.3	-	13	4874	c.4874A>G	c.(4873-4875)CAA>CGA	p.Q1625R		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1625										ovary(4)|skin(1)	5						CTTTTTAGGTTGGTTTTCATT	0.388													34	61					0	0	0	0	C	118217058	C	C	118217058	3	2	7	1	0	0	0	0	1	0	0	0	8253	1812	63	5	263	5	KIAA1210	23	118217058	Missense_Mutation	SNP	T	TCGA-BA-5151-01A-01D-1434-08		118217058	37053502	104	1889											
MXRA8	54587	broad.mit.edu	37	chr1	1290234	1290234	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcggcgacctccagcggctcGatacgcagtgagaagtcacc	9	6	12	14	5	1	1	1	1	0	1	4	4	2	1	3	2	2	2	3	2	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:1290234G>C	uc001aew.2	-	5	808	c.777C>G	c.(775-777)ATC>ATG	p.I259M	MXRA8_uc001aex.3_Missense_Mutation_p.I259M|MXRA8_uc001aey.3_Missense_Mutation_p.I259M|MXRA8_uc010nyl.1_Missense_Mutation_p.I259M|MXRA8_uc001aez.2_Missense_Mutation_p.I158M|MXRA8_uc001afa.2_Missense_Mutation_p.I250M	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	259	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCAGCGGCTCGATACGCAGTG	0.687													9	30					0	0	0	0	C	1290234	C	C	1290234	3	2	8	1	0	0	0	0	1	0	0	0	10058	1048	37	3	575	3	MXRA8	1	1290234	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08		1290234	247960387	1	1890											
ATAD3B	83858	broad.mit.edu	37	chr1	1417591	1417591	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaccgaggcccgggcgcgCgccaaggccgagcgggagaa	9	0	19	13	7	0	2	0	0	0	2	0	6	0	2	4	4	1	0	4	4	2	0	rs143801965		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:1417591C>T	uc001afv.2	+	6	689	c.588C>T	c.(586-588)CGC>CGT	p.R196R	ATAD3B_uc001afw.2_Silent_p.R150R|ATAD3B_uc001afx.2_Silent_p.R150R	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	196	Potential.						ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCCGGGCGCGCGCCAAGGCCG	0.662													22	21					0	0	0	0	T	1417591	T	T	1417591	2	4	8	1	0	0	0	0	0	0	0	1	1076	755	27	1		1	ATAD3B	1	1417591	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	127357	1417591	247833030	2	1891											
GNB1	2782	broad.mit.edu	37	chr1	1721851	1721851	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacgcaaatggcattgatgtCagactcgtggccagtgaagg	11	8	13	9	2	1	3	1	2	0	1	2	3	1	3	1	3	0	2	1	3	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:1721851C>T	uc001aif.2	-	9	1014	c.682G>A	c.(682-684)GAC>AAC	p.D228N	GNB1_uc009vky.2_Missense_Mutation_p.D128N	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	228	WD 5.				cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		GCATTGATGTCAGACTCGTGG	0.532													6	93					0	0	0	0	T	1721851	T	T	1721851	3	4	8	1	0	0	0	0	1	0	0	0	6552	826	29	2	352	2	GNB1	1	1721851	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	304260	1721851	247528770	3	1892											
MEGF6	1953	broad.mit.edu	37	chr1	3427384	3427384	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcggcactgagccggtagccGgcgtagcagccgcactcgta	7	6	14	14	6	0	1	0	1	0	0	2	1	0	1	3	3	4	6	3	3	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:3427384G>A	uc001akl.2	-	10	1424	c.1197C>T	c.(1195-1197)GCC>GCT	p.A399A	MEGF6_uc001akk.2_Silent_p.A294A	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	399	EGF-like 7.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCCGGTAGCCGGCGTAGCAGC	0.672													30	41					0	0	0	0	A	3427384	A	A	3427384	2	1	8	1	0	0	0	0	0	0	0	1	9515	1103	39	1		1	MEGF6	1	3427384	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1705533	3427384	245823237	4	1893											
AADACL4	343066	broad.mit.edu	37	chr1	12726206	12726206	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatccagttgtccaggcattCtgtttgcagttgccatcctt	6	16	8	11	0	1	0	0	0	1	0	4	0	4	0	4	1	2	5	4	1	1	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:12726206C>G	uc001auf.2	+	4	684	c.684C>G	c.(682-684)TTC>TTG	p.F228L		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	228	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TCCAGGCATTCTGTTTGCAGT	0.527													102	177					0	0	0	0	G	12726206	G	G	12726206	3	3	8	1	0	0	0	0	1	0	0	0	13	912	32	2	698	2	AADACL4	1	12726206	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	9298822	12726206	236524415	5	1894											
EPHA2	1969	broad.mit.edu	37	chr1	16461683	16461683	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cattgtagctgttggagtctCcctgtgggtgggtggccggc	3	12	17	9	1	1	0	0	0	1	0	2	1	1	1	2	5	1	3	2	5	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:16461683C>G	uc001aya.1	-	7	1567	c.1430G>C	c.(1429-1431)GGA>GCA	p.G477A		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	477	Extracellular (Potential).|Fibronectin type-III 2.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GTTGGAGTCTCCCTGTGGGTG	0.677													66	144					0	0	0	0	G	16461683	G	G	16461683	3	3	8	1	0	0	0	0	1	0	0	0	5191	869	30	2	1544	2	EPHA2	1	16461683	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3735477	16461683	232788938	6	1895											
EPHA2	1969	broad.mit.edu	37	chr1	16464404	16464404	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcggctggttaccaggcctGagacgccattgcgggcctcc	5	8	14	14	3	0	1	0	1	0	1	1	2	1	1	5	4	3	2	5	4	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:16464404G>C	uc001aya.1	-	5	1393	c.1256C>G	c.(1255-1257)TCA>TGA	p.S419*	EPHA2_uc010oca.1_Nonsense_Mutation_p.S419*	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	419	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	TACCAGGCCTGAGACGCCATT	0.637													17	79					0	0	0	0	C	16464404	C	C	16464404	4	2	8	1	0	0	0	0	0	1	0	0	5191	1294	45	2	1726	2	EPHA2	1	16464404	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2721	16464404	232786217	7	1896											
EPHA2	1969	broad.mit.edu	37	chr1	16475323	16475323	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgtagtccaggtccgactCggcatagtagaggttgaaag	10	8	14	9	3	0	2	0	1	0	1	3	3	2	2	3	3	0	4	3	3	4	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:16475323C>T	uc001aya.1	-	3	510	c.373G>A	c.(373-375)GAG>AAG	p.E125K	EPHA2_uc010oca.1_Missense_Mutation_p.E125K	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	125	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	AGGTCCGACTCGGCATAGTAG	0.547													31	60					0	0	0	0	T	16475323	T	T	16475323	3	4	8	1	0	0	0	0	1	0	0	0	5191	893	31	1	2617	1	EPHA2	1	16475323	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	10919	16475323	232775298	8	1897											
CROCC	9696	broad.mit.edu	37	chr1	17264170	17264170	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctggcagtgaagcgtcttGagaagcagaatctggagaag	12	7	15	7	1	2	4	0	2	2	3	2	6	2	4	1	2	2	2	1	2	4	1	rs141704732		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:17264170G>C	uc001azt.2	+	10	1297	c.1228G>C	c.(1228-1230)GAG>CAG	p.E410Q	CROCC_uc009voy.1_Missense_Mutation_p.E113Q|CROCC_uc009voz.1_Missense_Mutation_p.E173Q|CROCC_uc001azu.2_5'Flank	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	410	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GAAGCGTCTTGAGAAGCAGAA	0.572													6	18					0	0	0	0	C	17264170	C	C	17264170	3	2	8	1	0	0	0	0	1	0	0	0	3908	1291	45	2	1266	2	CROCC	1	17264170	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	788847	17264170	231986451	9	1898											
ARHGEF10L	55160	broad.mit.edu	37	chr1	18023375	18023375	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctcactcaacgggcactgtGggcctgtggccttcctggct	4	11	12	14	1	2	0	2	0	1	0	4	0	3	0	3	4	1	2	3	4	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:18023375G>A	uc001ban.2	+	29	3499	c.3340G>A	c.(3340-3342)GGG>AGG	p.G1114R	ARHGEF10L_uc001bao.2_Missense_Mutation_p.G1075R|ARHGEF10L_uc001bap.2_Missense_Mutation_p.G1070R|ARHGEF10L_uc001baq.2_Missense_Mutation_p.G875R|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.G887R|ARHGEF10L_uc001bar.2_Missense_Mutation_p.G817R|ARHGEF10L_uc009vpf.2_RNA|ARHGEF10L_uc001bas.2_Missense_Mutation_p.G138R	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	1114					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CGGGCACTGTGGGCCTGTGGC	0.627											OREG0013156	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	32					0	0	0	0	A	18023375	A	A	18023375	3	1	8	1	0	0	0	0	1	0	0	0	895	1348	47	4	3450	4	ARHGEF10L	1	18023375	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	759205	18023375	231227246	10	1899											
UBR4	23352	broad.mit.edu	37	chr1	19407997	19407997	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtccacttcaaaggcactctCcacccacttctccttgggct	7	11	6	17	0	3	0	1	0	2	0	6	0	4	0	4	2	0	2	4	2	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:19407997C>G	uc001bbi.2	-	103	15083	c.15079G>C	c.(15079-15081)GAG>CAG	p.E5027Q	UBR4_uc001bbf.2_5'UTR|UBR4_uc010ocv.1_Missense_Mutation_p.E550Q|UBR4_uc009vph.2_Missense_Mutation_p.E661Q|UBR4_uc010ocw.1_Missense_Mutation_p.E691Q|UBR4_uc001bbg.2_Missense_Mutation_p.E738Q|UBR4_uc001bbh.2_Missense_Mutation_p.E736Q	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	5027					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AAGGCACTCTCCACCCACTTC	0.517													92	195					0	0	0	0	G	19407997	G	G	19407997	3	3	8	1	0	0	0	0	1	0	0	0	16972	864	30	2	488	2	UBR4	1	19407997	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1384622	19407997	229842624	11	1900											
UBR4	23352	broad.mit.edu	37	chr1	19446699	19446699	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgtgcagtgtcagacagtGggcctgccagcgcaccgagg	8	6	16	11	2	1	1	1	0	0	1	1	3	1	1	3	2	3	2	3	2	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:19446699G>A	uc001bbi.2	-	69	10289	c.10285C>T	c.(10285-10287)CAC>TAC	p.H3429Y	UBR4_uc001bbj.1_5'Flank	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3429					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GTCAGACAGTGGGCCTGCCAG	0.512													13	108					0	0	0	0	A	19446699	A	A	19446699	3	1	8	1	0	0	0	0	1	0	0	0	16972	1348	47	4	5418	4	UBR4	1	19446699	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	38702	19446699	229803922	12	1901											
NUDC	10726	broad.mit.edu	37	chr1	27272172	27272172	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaagaaacaggagattctGaagaagtgagcaattcagag	18	6	12	5	0	2	7	1	2	1	5	2	8	2	7	0	1	2	1	0	1	5	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:27272172G>A	uc001bng.1	+	8	1055	c.939G>A	c.(937-939)CTG>CTA	p.L313L	NUDC_uc001bnh.1_Silent_p.L370L|NUDC_uc009vsq.1_Silent_p.L287L	NM_006600	NP_006591	Q9Y266	NUDC_HUMAN	nuclear distribution gene C homolog	313					cell proliferation|cytokinesis|mitotic prometaphase|multicellular organismal development	cytosol|microtubule|nucleoplasm	protein binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;6.1e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.87e-29)|Colorectal(126;5.74e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000281)|STAD - Stomach adenocarcinoma(196;0.000604)|KIRC - Kidney renal clear cell carcinoma(1967;0.000739)|READ - Rectum adenocarcinoma(331;0.0421)		AGGAGATTCTGAAGAAGTGAG	0.547													8	124					0	0	0	0	A	27272172	A	A	27272172	2	1	8	1	0	0	0	0	0	0	0	1	10775	1277	45	2		2	NUDC	1	27272172	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	7825473	27272172	221978449	13	1902											
AHDC1	27245	broad.mit.edu	37	chr1	27877465	27877465	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacaggatctttggcctatCagtgcgccgcaaggcgtact	9	9	11	12	3	2	0	1	0	1	0	2	1	2	1	2	3	2	2	2	3	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:27877465C>T	uc009vsy.2	-	6	2131	c.1162G>A	c.(1162-1164)GAT>AAT	p.D388N	AHDC1_uc009vsz.1_Missense_Mutation_p.D388N|AHDC1_uc001boh.1_Missense_Mutation_p.D261N	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	388	Pro-rich.						DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		TTTGGCCTATCAGTGCGCCGC	0.716													6	15					0	0	0	0	T	27877465	T	T	27877465	3	4	8	1	0	0	0	0	1	0	0	0	412	826	29	2	3653	2	AHDC1	1	27877465	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	605293	27877465	221373156	14	1903											
C1orf38	9473	broad.mit.edu	37	chr1	28211959	28211959	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaagccccaaaggcaggatCtaggtgagtccctgtgggcg	9	7	14	11	1	1	1	0	1	1	0	2	2	2	2	3	4	1	1	3	4	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:28211959C>G	uc001bpc.3	+	5	1901	c.1873C>G	c.(1873-1875)CTA>GTA	p.L625V	C1orf38_uc001boz.2_3'UTR|C1orf38_uc001bpa.2_3'UTR|C1orf38_uc010ofn.1_Missense_Mutation_p.L429V|C1orf38_uc010ofo.1_Missense_Mutation_p.L496V	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	625					cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		AAGGCAGGATCTAGGTGAGTC	0.597													11	29					0	0	0	0	G	28211959	G	G	28211959	3	3	8	1	0	0	0	0	1	0	0	0	2049	912	32	2	1891	2	C1orf38	1	28211959	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	334494	28211959	221038662	15	1904											
BSDC1	55108	broad.mit.edu	37	chr1	32841914	32841914	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccactatccgagttcagctCaaacacccgtaagtctgtgg	10	9	8	14	2	3	0	2	0	1	0	4	1	4	0	3	1	2	3	3	1	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:32841914C>G	uc001bvh.3	-	9	1152	c.1105G>C	c.(1105-1107)GAG>CAG	p.E369Q	BSDC1_uc010ohg.1_Missense_Mutation_p.E386Q|BSDC1_uc010ohh.1_Missense_Mutation_p.E313Q|BSDC1_uc010ohi.1_Missense_Mutation_p.E274Q|BSDC1_uc001bvg.3_RNA|BSDC1_uc001bvj.2_Missense_Mutation_p.E265Q|BSDC1_uc001bvi.2_Missense_Mutation_p.E386Q	NM_018045	NP_060515	Q9NW68	BSDC1_HUMAN	BSD domain containing 1 isoform b	369							protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GAGTTCAGCTCAAACACCCGT	0.617													47	121					0	0	0	0	G	32841914	G	G	32841914	3	3	8	1	0	0	0	0	1	0	0	0	1533	835	29	2	199	2	BSDC1	1	32841914	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4629955	32841914	216408707	16	1905											
KIAA1522	57648	broad.mit.edu	37	chr1	33234274	33234274	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcccggacggggccggatGaagacaacatctccttctgc	8	7	11	15	3	2	2	0	1	2	1	4	4	3	4	4	4	2	0	4	4	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:33234274G>A	uc001bvv.2	+	4	443	c.307G>A	c.(307-309)GAA>AAA	p.E103K	KIAA1522_uc001bvu.1_Missense_Mutation_p.E162K|KIAA1522_uc010ohm.1_Missense_Mutation_p.E114K|KIAA1522_uc010ohn.1_Missense_Mutation_p.E103K	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	103											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GGGGCCGGATGAAGACAACAT	0.532													11	49					0	0	0	0	A	33234274	A	A	33234274	3	1	8	1	0	0	0	0	1	0	0	0	8277	1291	45	2	498	2	KIAA1522	1	33234274	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	392360	33234274	216016347	17	1906											
KIAA1522	57648	broad.mit.edu	37	chr1	33234319	33234319	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaccacatcctacgtggctGagagctccacagcagaggac	12	5	11	13	1	0	3	0	1	0	3	2	5	2	4	3	2	3	3	3	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:33234319G>C	uc001bvv.2	+	4	488	c.352G>C	c.(352-354)GAG>CAG	p.E118Q	KIAA1522_uc001bvu.1_Missense_Mutation_p.E177Q|KIAA1522_uc010ohm.1_Missense_Mutation_p.E129Q|KIAA1522_uc010ohn.1_Missense_Mutation_p.E118Q	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	118											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CTACGTGGCTGAGAGCTCCAC	0.602													5	30					0	0	0	0	C	33234319	C	C	33234319	3	2	8	1	0	0	0	0	1	0	0	0	8277	1291	45	2	543	2	KIAA1522	1	33234319	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	45	33234319	216016302	18	1907											
DLGAP3	58512	broad.mit.edu	37	chr1	35334493	35334493	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtaggcccactggccctgcGtgtggaccgtgcggaagact	6	7	16	12	3	0	1	0	0	0	1	0	3	0	3	3	5	2	1	3	5	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:35334493G>A	uc001byc.2	-	7	2198	c.2198C>T	c.(2197-2199)ACG>ATG	p.T733M		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	733					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				CTGGCCCTGCGTGTGGACCGT	0.592													12	12					0	0	0	0	A	35334493	A	A	35334493	3	1	8	1	0	0	0	0	1	0	0	0	4583	1145	40	1	757	1	DLGAP3	1	35334493	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2100174	35334493	213916128	19	1908											
NCDN	23154	broad.mit.edu	37	chr1	36024783	36024783	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agggccgaaaccccaccctgGagcgctacctgggagccctc	8	4	12	17	2	0	0	0	0	0	0	1	3	0	2	6	3	4	1	6	3	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:36024783G>A	uc001bza.2	+	3	236	c.109G>A	c.(109-111)GAG>AAG	p.E37K	KIAA0319L_uc001byx.2_5'Flank|KIAA0319L_uc010ohw.1_5'Flank|KIAA0319L_uc001byz.2_5'Flank|KIAA0319L_uc010ohx.1_5'Flank|NCDN_uc001bzb.2_Missense_Mutation_p.E37K|NCDN_uc001bzc.2_Missense_Mutation_p.E20K	NM_001014839	NP_001014839	Q9UBB6	NCDN_HUMAN	neurochondrin isoform 1	37					neuron projection development	cytosol|dendrite|neuronal cell body				large_intestine(2)|pancreas(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCCCACCCTGGAGCGCTACCT	0.597													21	78					0	0	0	0	A	36024783	A	A	36024783	3	1	8	1	0	0	0	0	1	0	0	0	10268	1175	41	2	115	2	NCDN	1	36024783	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	690290	36024783	213225838	20	1909											
EIF2C3	192669	broad.mit.edu	37	chr1	36506033	36506033	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgattattttgtgctgatagGacagaaagggtaatctcacc	12	12	10	7	1	1	2	1	1	1	1	2	4	1	3	1	2	1	2	1	2	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:36506033G>C	uc001bzp.2	+	16	2419	c.2163G>C	c.(2161-2163)AGG>AGC	p.R721S	EIF2C3_uc001bzq.2_Missense_Mutation_p.R487S	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	721	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTGCTGATAGGACAGAAAGGG	0.413													26	75					0	0	0	0	C	36506033	C	C	36506033	3	2	8	1	0	0	0	0	1	0	0	0	5029	1165	41	2	2225	2	EIF2C3	1	36506033	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	481250	36506033	212744588	21	1910											
MUTYH	4595	broad.mit.edu	37	chr1	45796983	45796983	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatacttgatatgtcagcttGatgtgagagaaggtgtggac	11	13	13	4	0	1	4	1	3	0	1	1	6	1	5	0	2	2	1	0	2	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:45796983G>C	uc001cnm.2	-	14	1554	c.1338C>G	c.(1336-1338)ATC>ATG	p.I446M	MUTYH_uc009vxn.2_Missense_Mutation_p.I271M|MUTYH_uc001cnf.2_Missense_Mutation_p.I421M|MUTYH_uc009vxo.2_Missense_Mutation_p.I421M|MUTYH_uc001cng.2_Missense_Mutation_p.I432M|MUTYH_uc001cnj.2_Missense_Mutation_p.I329M|MUTYH_uc001cni.2_Missense_Mutation_p.I421M|MUTYH_uc001cnh.2_Missense_Mutation_p.I422M|MUTYH_uc001cno.2_Missense_Mutation_p.I329M|MUTYH_uc001cnk.2_Missense_Mutation_p.I306M|MUTYH_uc010oll.1_Missense_Mutation_p.I130M|MUTYH_uc001cnl.2_Missense_Mutation_p.I435M|MUTYH_uc009vxp.2_Missense_Mutation_p.I449M|MUTYH_uc001cnn.2_Missense_Mutation_p.I436M	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	446	Nudix hydrolase.				depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					ATGTCAGCTTGATGTGAGAGA	0.537			Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				11	58					0	0	0	0	C	45796983	C	C	45796983	3	2	8	1	0	0	0	0	1	0	0	0	10046	1280	45	2	314	2	MUTYH	1	45796983	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	9290950	45796983	203453638	22	1911											
CYP4X1	260293	broad.mit.edu	37	chr1	47515108	47515108	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcaggtctttgaccccttGaggttctctcaggagaattc	7	15	9	10	0	4	3	2	2	2	1	6	4	4	3	2	3	0	1	2	3	1	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:47515108G>C	uc001cqt.2	+	11	1537	c.1287G>C	c.(1285-1287)TTG>TTC	p.L429F	CYP4X1_uc001cqr.2_Missense_Mutation_p.L428F|CYP4X1_uc001cqs.2_Missense_Mutation_p.L364F	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	429						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						TTGACCCCTTGAGGTTCTCTC	0.423													36	95					0	0	0	0	C	47515108	C	C	47515108	3	2	8	1	0	0	0	0	1	0	0	0	4210	1281	45	2	1329	2	CYP4X1	1	47515108	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1718125	47515108	201735513	23	1912											
SGIP1	84251	broad.mit.edu	37	chr1	67155939	67155939	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagcacccttagcgcgggctGaaagcacttcttcaatatcg	10	10	9	12	3	2	1	1	1	1	0	3	1	2	1	1	1	3	3	1	1	5	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:67155939G>A	uc001dcr.2	+	17	1727	c.1510G>A	c.(1510-1512)GAA>AAA	p.E504K	SGIP1_uc010opd.1_Missense_Mutation_p.E104K|SGIP1_uc001dcs.2_Missense_Mutation_p.E104K|SGIP1_uc001dct.2_Missense_Mutation_p.E104K|SGIP1_uc009wat.2_Missense_Mutation_p.E298K	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	504					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						AGCGCGGGCTGAAAGCACTTC	0.453													55	140					0	0	0	0	A	67155939	A	A	67155939	3	1	8	1	0	0	0	0	1	0	0	0	14271	1291	45	2	1576	2	SGIP1	1	67155939	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	19640831	67155939	182094682	24	1913											
C1orf141	400757	broad.mit.edu	37	chr1	67558949	67558949	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaattctgtgagaaattataGagtgtattccaagatctgtt	14	15	8	4	0	2	3	0	1	2	3	3	4	3	3	1	0	0	2	1	0	6	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:67558949G>C	uc001ddl.1	-	7	1053	c.942C>G	c.(940-942)CTC>CTG	p.L314L	C1orf141_uc001ddm.1_Silent_p.L314L|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	314										ovary(1)	1						AGAAATTATAGAGTGTATTCC	0.343													31	98					0	0	0	0	C	67558949	C	C	67558949	2	2	8	1	0	0	0	0	0	0	0	1	2010	929	33	2		2	C1orf141	1	67558949	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	403010	67558949	181691672	25	1914											
LRRC7	57554	broad.mit.edu	37	chr1	70505167	70505167	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacccttcatatcaagaagtGaaagctcaggcgggaagttt	13	9	10	9	1	3	2	3	1	0	1	3	3	3	3	1	2	1	2	1	2	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:70505167G>C	uc001dep.2	+	19	3576	c.3546G>C	c.(3544-3546)GTG>GTC	p.V1182V	LRRC7_uc009wbg.2_Silent_p.V466V|LRRC7_uc001deq.2_Silent_p.V423V	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1182						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						ATCAAGAAGTGAAAGCTCAGG	0.502													15	53					0	0	0	0	C	70505167	C	C	70505167	2	2	8	1	0	0	0	0	0	0	0	1	9070	1277	45	2		2	LRRC7	1	70505167	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2946218	70505167	178745454	26	1915											
USP33	23032	broad.mit.edu	37	chr1	78163136	78163136	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaaaattccatgtttcttCagaaatctggccagaatctg	13	12	7	9	0	4	3	1	0	3	3	5	3	5	3	2	1	0	1	2	1	4	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:78163136C>T	uc001dht.2	-	25	3042	c.2695G>A	c.(2695-2697)GAA>AAA	p.E899K	USP33_uc009wca.1_RNA|USP33_uc001dhs.2_3'UTR|USP33_uc001dhu.2_Missense_Mutation_p.E868K	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	899	DUSP 2.				axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						CATGTTTCTTCAGAAATCTGG	0.388													35	114					0	0	0	0	T	78163136	T	T	78163136	3	4	8	1	0	0	0	0	1	0	0	0	17132	835	29	2	137	2	USP33	1	78163136	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7657969	78163136	171087485	27	1916											
LRRC8C	84230	broad.mit.edu	37	chr1	90178699	90178699	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaaaaggacaacaggaaGaacaacatgaacaggtccaa	22	2	10	7	0	0	3	0	1	0	2	1	6	1	5	1	3	4	0	1	3	9	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:90178699G>C	uc001dnl.3	+	3	812	c.570G>C	c.(568-570)AAG>AAC	p.K190N		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	190						endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		ACAACAGGAAGAACAACATGA	0.453													17	78					0	0	0	0	C	90178699	C	C	90178699	3	2	8	1	0	0	0	0	1	0	0	0	9073	933	33	2	576	2	LRRC8C	1	90178699	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	12015563	90178699	159071922	28	1917											
ABCA4	24	broad.mit.edu	37	chr1	94528713	94528713	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaccacgtctatgtccattCggatcttatacttcacgtgg	8	13	7	13	3	3	0	1	0	2	0	5	1	4	1	3	2	1	0	3	2	3	5	rs61748559		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:94528713C>T	uc001dqh.2	-	12	1819	c.1715G>A	c.(1714-1716)CGA>CAA	p.R572Q	ABCA4_uc010otn.1_Missense_Mutation_p.R572Q	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	572	Extracellular.		R -> P (in STGD1).|R -> Q (in STGD1).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TATGTCCATTCGGATCTTATA	0.473													58	148					0	0	0	0	T	94528713	T	T	94528713	3	4	8	1	0	0	0	0	1	0	0	0	34	884	31	1	5262	1	ABCA4	1	94528713	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4350014	94528713	154721908	29	1918											
WDR77	79084	broad.mit.edu	37	chr1	111990152	111990152	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatacttgcagaacttgctGacaataagtgtctcattctc	11	14	6	10	0	3	2	2	1	2	1	5	2	3	2	0	0	4	2	0	0	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:111990152G>A	uc001ebb.2	-	3	387	c.348C>T	c.(346-348)GTC>GTT	p.V116V	WDR77_uc010owd.1_Intron|WDR77_uc010owe.1_Intron|ATP5F1_uc009wgf.1_5'Flank|ATP5F1_uc001ebc.2_5'Flank|ATP5F1_uc001ebd.3_5'Flank	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	116	WD 1.				ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGAACTTGCTGACAATAAGTG	0.453													11	40					0	0	0	0	A	111990152	A	A	111990152	2	1	8	1	0	0	0	0	0	0	0	1	17395	1277	45	2		2	WDR77	1	111990152	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	17461439	111990152	137260469	30	1919											
DDX20	11218	broad.mit.edu	37	chr1	112303904	112303904	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttcctgctgagtgcatttCaggtaagttcatctcttact	7	17	7	10	0	3	1	2	1	1	0	5	1	4	1	1	1	3	4	1	1	2	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:112303904C>T	uc001ebs.2	+	7	1376	c.1019C>T	c.(1018-1020)TCA>TTA	p.S340L	DDX20_uc010owf.1_Missense_Mutation_p.S102L|DDX20_uc001ebt.2_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	340	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGTGCATTTCAGGTAAGTTC	0.338													11	78					0	0	0	0	T	112303904	T	T	112303904	3	4	8	1	0	0	0	0	1	0	0	0	4365	838	29	2	1045	2	DDX20	1	112303904	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	313752	112303904	136946717	31	1920											
PDZK1	5174	broad.mit.edu	37	chr1	145761230	145761230	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaagaactgcccaatggctCtgtcaaggaggctccagctc	10	8	10	13	0	3	1	2	0	1	1	5	2	4	2	2	3	3	3	2	3	4	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:145761230C>A	uc001eon.1	+	8	1140	c.1043C>A	c.(1042-1044)TCT>TAT	p.S348Y	NBPF10_uc001emp.3_Intron|PDZK1_uc001eoo.1_Missense_Mutation_p.S348Y|PDZK1_uc010oza.1_Missense_Mutation_p.S237Y	NM_002614	NP_002605	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	348					carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			CCCAATGGCTCTGTCAAGGAG	0.423													22	67					7.04047e-22	7.57304e-22	1	0	A	145761230	A	A	145761230	3	1	8	1	0	0	0	0	1	0	0	0	11761	913	32	2	1065	2	PDZK1	1	145761230	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	33457326	145761230	103489391	32	1921											
HIST2H3D	653604	broad.mit.edu	37	chr1	149784945	149784945	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagccccaccaggtaggcctCgctggcctcctgcagcgcca	6	5	11	19	2	0	0	0	0	0	0	2	0	1	0	7	3	3	3	7	3	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:149784945C>T	uc010pbl.1	-	1	292	c.292G>A	c.(292-294)GAG>AAG	p.E98K	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	98					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						AGGTAGGCCTCGCTGGCCTCC	0.642													14	50					0	0	0	0	T	149784945	T	T	149784945	3	4	8	1	0	0	0	0	1	0	0	0	7220	893	31	1	120	1	HIST2H3D	1	149784945	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4023715	149784945	99465676	33	1922											
RFX5	5993	broad.mit.edu	37	chr1	151317305	151317305	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacatgtactcctcattgctCagtgtacttggctctgagct	7	15	8	11	0	3	1	2	1	1	0	4	1	4	1	1	1	5	5	1	1	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:151317305C>A	uc001exv.1	-	6	466	c.252G>T	c.(250-252)CTG>CTT	p.L84L	RFX5_uc001exw.1_Silent_p.L84L|RFX5_uc009wmr.1_Silent_p.L84L|RFX5_uc010pcx.1_Intron	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	84	N-terminal domain.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCTCATTGCTCAGTGTACTTG	0.463													8	59					7.48243e-07	7.76643e-07	1	0	A	151317305	A	A	151317305	2	1	8	1	0	0	0	0	0	0	0	1	13331	813	29	2		2	RFX5	1	151317305	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1532360	151317305	97933316	34	1923											
TCHH	7062	broad.mit.edu	37	chr1	152079998	152079998	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttgggattttatctcccCgacttggcggtgcctctgtt	3	17	10	11	2	3	0	0	0	3	0	4	2	3	1	3	3	1	1	3	3	1	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:152079998C>T	uc001ezp.2	-	2	5695	c.5695G>A	c.(5695-5697)GGG>AGG	p.G1899R	TCHH_uc009wne.1_Missense_Mutation_p.G1899R	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1899					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTATCTCCCCGACTTGGCGG	0.582													27	105					0	0	0	0	T	152079998	T	T	152079998	3	4	8	1	0	0	0	0	1	0	0	0	15766	652	23	1	140	1	TCHH	1	152079998	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	762693	152079998	97170623	35	1924											
FLG	2312	broad.mit.edu	37	chr1	152282518	152282518	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagatccataatggtttctgGaagccgactcagaccgcctc	10	9	9	13	2	2	2	1	0	1	2	4	4	3	3	4	2	1	1	4	2	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:152282518G>A	uc001ezu.1	-	3	4880	c.4844C>T	c.(4843-4845)TCC>TTC	p.S1615F		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1615	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGTTTCTGGAAGCCGACTC	0.572									Ichthyosis				57	147					0	0	0	0	A	152282518	A	A	152282518	3	1	8	1	0	0	0	0	1	0	0	0	5954	1174	41	2	7345	2	FLG	1	152282518	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	202520	152282518	96968103	36	1925											
KPRP	448834	broad.mit.edu	37	chr1	152733229	152733229	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgtccaccacggcgtcttGaccagtgtccagagtcacca	8	9	9	15	2	3	2	1	1	2	1	5	2	5	2	5	1	0	0	5	1	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:152733229G>C	uc001fal.1	+	2	1223	c.1165G>C	c.(1165-1167)GAC>CAC	p.D389H		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	389	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACGGCGTCTTGACCAGTGTCC	0.647													15	31					0	0	0	0	C	152733229	C	C	152733229	3	2	8	1	0	0	0	0	1	0	0	0	8475	1290	45	2	1167	2	KPRP	1	152733229	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	450711	152733229	96517392	37	1926											
S100A2	6273	broad.mit.edu	37	chr1	153533966	153533966	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcattgcacatgacagtgatGagtgccaggaaaacagcata	15	8	10	8	0	1	3	1	3	0	0	1	4	1	4	1	1	4	2	1	1	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:153533966G>A	uc001fcb.2	-	3	581	c.243C>T	c.(241-243)CTC>CTT	p.L81L		NM_005978	NP_005969	P29034	S10A2_HUMAN	S100 calcium binding protein A2	82	EF-hand 2.				endothelial cell migration		calcium ion binding			ovary(1)	1	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGACAGTGATGAGTGCCAGGA	0.542													4	184					0	0	0	0	A	153533966	A	A	153533966	2	1	8	1	0	0	0	0	0	0	0	1	13843	1277	45	2		2	S100A2	1	153533966	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	800737	153533966	95716655	38	1927											
ZBTB7B	51043	broad.mit.edu	37	chr1	154988249	154988249	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaggacccacacaggcgaGaagccctttgcctgcgaggt	10	6	13	12	2	0	2	0	1	0	1	0	5	0	3	3	3	3	0	3	3	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:154988249G>C	uc001fgk.3	+	3	1271	c.1113G>C	c.(1111-1113)GAG>GAC	p.E371D	ZBTB7B_uc009wpa.2_Missense_Mutation_p.E371D|ZBTB7B_uc001fgj.3_Missense_Mutation_p.E405D|ZBTB7B_uc010peq.1_Missense_Mutation_p.E405D|ZBTB7B_uc001fgl.3_Missense_Mutation_p.E371D	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	371					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ACACAGGCGAGAAGCCCTTTG	0.647													10	52					0	0	0	0	C	154988249	C	C	154988249	3	2	8	1	0	0	0	0	1	0	0	0	17621	933	33	2	1115	2	ZBTB7B	1	154988249	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1454283	154988249	94262372	39	1928											
ADAM15	8751	broad.mit.edu	37	chr1	155026830	155026830	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cagagagaagctataccctgGagcaggggcctggggacctt	10	6	15	10	0	0	2	0	0	0	2	0	5	0	4	3	5	3	2	3	5	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:155026830G>C	uc001fgr.1	+	6	561	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	ADAM15_uc001fgq.1_5'UTR|ADAM15_uc009wpc.1_RNA|ADAM15_uc010pet.1_Missense_Mutation_p.E138Q|ADAM15_uc010peu.1_Missense_Mutation_p.E171Q|ADAM15_uc001fgt.1_Missense_Mutation_p.E154Q|ADAM15_uc010pev.1_Missense_Mutation_p.E164Q|ADAM15_uc001fgs.1_Missense_Mutation_p.E154Q|ADAM15_uc001fgu.1_Missense_Mutation_p.E154Q|ADAM15_uc001fgw.1_Missense_Mutation_p.E154Q|ADAM15_uc001fgv.1_Missense_Mutation_p.E154Q|ADAM15_uc001fgx.1_Missense_Mutation_p.E154Q|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	154					angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CTATACCCTGGAGCAGGGGCC	0.547													24	87					0	0	0	0	C	155026830	C	C	155026830	3	2	8	1	0	0	0	0	1	0	0	0	237	1175	41	2	482	2	ADAM15	1	155026830	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	38581	155026830	94223791	40	1929											
FDPS	2224	broad.mit.edu	37	chr1	155279943	155279943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatcgttagggtgctgactGaggatgagatggggcaccca	10	8	16	7	1	0	4	0	3	0	2	1	6	0	5	1	4	1	3	1	4	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:155279943G>A	uc001fkc.2	+	3	505	c.286G>A	c.(286-288)GAG>AAG	p.E96K	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Missense_Mutation_p.E30K|FDPS_uc001fke.2_Missense_Mutation_p.E96K|FDPS_uc001fkf.2_Missense_Mutation_p.E30K	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	96					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	GGTGCTGACTGAGGATGAGAT	0.512													18	64					0	0	0	0	A	155279943	A	A	155279943	3	1	8	1	0	0	0	0	1	0	0	0	5835	1291	45	2	292	2	FDPS	1	155279943	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	253113	155279943	93970678	41	1930											
YY1AP1	55249	broad.mit.edu	37	chr1	155629559	155629559	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcctggatgccctgagggagCggctccagagcttgccttcc	5	9	13	14	1	0	2	0	1	0	1	3	4	3	4	5	3	4	2	5	3	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:155629559C>T	uc001fln.2	-	11	2304	c.2280G>A	c.(2278-2280)CCG>CCA	p.P760P	YY1AP1_uc001flg.2_Silent_p.P499P|YY1AP1_uc010pgg.1_Silent_p.P599P|YY1AP1_uc010pgh.1_Silent_p.P703P|YY1AP1_uc010pgi.1_Silent_p.P852P|YY1AP1_uc001flh.2_Silent_p.P832P|YY1AP1_uc009wqt.2_Silent_p.P683P|YY1AP1_uc001flk.2_Silent_p.P703P|YY1AP1_uc001fll.2_Silent_p.P714P|YY1AP1_uc009wqv.2_Silent_p.P431P|YY1AP1_uc001flm.2_Silent_p.P703P|YY1AP1_uc001fli.2_Silent_p.P714P|YY1AP1_uc009wqu.2_Silent_p.P547P|YY1AP1_uc001flj.2_Silent_p.P694P|YY1AP1_uc009wqw.2_Silent_p.P683P|YY1AP1_uc001flo.2_Silent_p.P648P|YY1AP1_uc001flp.2_Silent_p.P714P	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	760					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CCTGAGGGAGCGGCTCCAGAG	0.512													25	105					0	0	0	0	T	155629559	T	T	155629559	2	4	8	1	0	0	0	0	0	0	0	1	17576	755	27	1		1	YY1AP1	1	155629559	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	349616	155629559	93621062	42	1931											
IFI16	3428	broad.mit.edu	37	chr1	159015213	159015213	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagccatccccacactcctCagatgcctccatcaacacca	12	6	4	19	0	2	2	2	0	0	2	5	2	5	2	7	0	3	0	7	0	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:159015213C>T	uc010pis.1	+	7	1467	c.1288C>T	c.(1288-1290)CAG>TAG	p.Q430*	IFI16_uc001ftg.2_Intron|IFI16_uc001fth.2_Intron|IFI16_uc010pit.1_Nonsense_Mutation_p.Q85*	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	486					cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					CCACACTCCTCAGATGCCTCC	0.483													12	136					0	0	0	0	T	159015213	T	T	159015213	4	4	8	1	0	0	0	0	0	1	0	0	7550	841	29	2		2	IFI16	1	159015213	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3385654	159015213	90235408	43	1932											
LMX1A	4009	broad.mit.edu	37	chr1	165322354	165322354	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacagcttcttgtcccggtaGaagcaggtggtctccagggg	7	10	14	10	1	2	1	0	0	2	1	4	1	3	1	2	5	3	3	2	5	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:165322354G>A	uc001gcy.1	-	2	443	c.222C>T	c.(220-222)TTC>TTT	p.F74F	LMX1A_uc001gcz.1_Silent_p.F74F	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	74	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					TGTCCCGGTAGAAGCAGGTGG	0.602													16	91					0	0	0	0	A	165322354	A	A	165322354	2	1	8	1	0	0	0	0	0	0	0	1	8903	933	33	2		2	LMX1A	1	165322354	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	6307141	165322354	83928267	44	1933											
DNM3	26052	broad.mit.edu	37	chr1	172348233	172348233	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaggcaagtggagaccattCgcaacctcgtagactcctac	12	7	10	12	2	0	3	0	0	0	3	3	4	1	3	3	2	2	3	3	2	4	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:172348233C>T	uc001gie.2	+	18	2145	c.1969C>T	c.(1969-1971)CGC>TGC	p.R657C	DNM3_uc001gif.2_Missense_Mutation_p.R653C|DNM3_uc001gih.1_Missense_Mutation_p.R13C	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	663	GED.				endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						GGAGACCATTCGCAACCTCGT	0.383													7	35					0	0	0	0	T	172348233	T	T	172348233	3	4	8	1	0	0	0	0	1	0	0	0	4695	884	31	1	2039	1	DNM3	1	172348233	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7025879	172348233	76902388	45	1934											
TNN	63923	broad.mit.edu	37	chr1	175048789	175048789	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagcggccacggcttctgtGacacgggcgagtgctactgc	6	7	15	13	4	1	1	0	1	1	0	1	2	1	1	1	3	4	3	1	3	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:175048789G>C	uc001gkl.1	+	3	843	c.730G>C	c.(730-732)GAC>CAC	p.D244H	TNN_uc010pmx.1_Missense_Mutation_p.D244H	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	244	EGF-like 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CGGCTTCTGTGACACGGGCGA	0.662													3	15					0	0	0	0	C	175048789	C	C	175048789	3	2	8	1	0	0	0	0	1	0	0	0	16389	1290	45	2	736	2	TNN	1	175048789	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2700556	175048789	74201832	46	1935											
SOAT1	6646	broad.mit.edu	37	chr1	179311320	179311320	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtactaaattcagctaaggaGaaatcaagtatgtaatttct	16	13	7	5	0	3	1	2	0	1	1	3	2	3	1	0	1	2	4	0	1	8	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:179311320G>C	uc001gml.2	+	8	915	c.852G>C	c.(850-852)GAG>GAC	p.E284D	SOAT1_uc010pni.1_Missense_Mutation_p.E219D|SOAT1_uc001gmm.2_Missense_Mutation_p.E226D|SOAT1_uc010pnj.1_Missense_Mutation_p.E20D|SOAT1_uc010pnk.1_Missense_Mutation_p.E219D	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	284					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	CAGCTAAGGAGAAATCAAGTA	0.254													9	40					0	0	0	0	C	179311320	C	C	179311320	3	2	8	1	0	0	0	0	1	0	0	0	14974	933	33	2	878	2	SOAT1	1	179311320	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4262531	179311320	69939301	47	1936											
CEP350	9857	broad.mit.edu	37	chr1	180080147	180080147	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctaggttcaggagctccatGaggaggaggcacagtgggtg	9	7	17	8	0	1	1	1	1	0	0	2	4	2	4	2	6	1	3	2	6	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:180080147G>C	uc001gnt.2	+	38	9588	c.9205G>C	c.(9205-9207)GAG>CAG	p.E3069Q	CEP350_uc009wxl.2_Missense_Mutation_p.E3068Q|CEP350_uc001gnv.2_Missense_Mutation_p.E1204Q|CEP350_uc001gnw.1_Missense_Mutation_p.E826Q|CEP350_uc001gnx.1_Missense_Mutation_p.E826Q	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	3069						centrosome|nucleus|spindle				ovary(4)	4						GGAGCTCCATGAGGAGGAGGC	0.413													14	71					0	0	0	0	C	180080147	C	C	180080147	3	2	8	1	0	0	0	0	1	0	0	0	3269	1291	45	2	9351	2	CEP350	1	180080147	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	768827	180080147	69170474	48	1937											
NCF2	4688	broad.mit.edu	37	chr1	183543724	183543724	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttttttccattcctccttCttggcatacatgaaagcaat	9	16	5	11	0	1	1	0	1	1	0	4	1	4	1	3	1	2	3	3	1	3	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:183543724C>G	uc001gqj.3	-	4	674	c.399G>C	c.(397-399)AAG>AAC	p.K133N	NCF2_uc010pod.1_Intron|NCF2_uc010poe.1_Intron|NCF2_uc001gqk.3_Missense_Mutation_p.K133N	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	133	TPR 3.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						ATTCCTCCTTCTTGGCATACA	0.438													27	79					0	0	0	0	G	183543724	G	G	183543724	3	3	8	1	0	0	0	0	1	0	0	0	10271	912	32	2	1229	2	NCF2	1	183543724	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3463577	183543724	65706897	49	1938											
FAM129A	116496	broad.mit.edu	37	chr1	184787891	184787891	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cactggtcccatgagctcctCcaggatggatgccaggaatg	9	8	12	12	0	0	1	0	1	0	0	3	4	3	4	4	4	2	1	4	4	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:184787891C>G	uc001gra.2	-	9	1248	c.1054G>C	c.(1054-1056)GAG>CAG	p.E352Q	FAM129A_uc001grb.1_Missense_Mutation_p.E115Q|FAM129A_uc009wyh.1_Missense_Mutation_p.E180Q|FAM129A_uc009wyi.1_Missense_Mutation_p.E150Q	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	352					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						ATGAGCTCCTCCAGGATGGAT	0.527													28	189					0	0	0	0	G	184787891	G	G	184787891	3	3	8	1	0	0	0	0	1	0	0	0	5464	864	30	2	1756	2	FAM129A	1	184787891	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1244167	184787891	64462730	50	1939											
KCNT2	343450	broad.mit.edu	37	chr1	196395022	196395022	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctttaagggctgaaccttGaaggtagataactcgttggg	11	12	12	6	1	1	3	0	2	1	1	2	3	1	3	1	3	2	3	1	3	5	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:196395022G>C	uc001gtd.1	-	11	1141	c.1081C>G	c.(1081-1083)CAA>GAA	p.Q361E	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.Q361E|KCNT2_uc001gtf.1_Missense_Mutation_p.Q361E|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.Q361E|KCNT2_uc009wyv.1_Missense_Mutation_p.Q336E	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	361	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						GCTGAACCTTGAAGGTAGATA	0.403													29	59					0	0	0	0	C	196395022	C	C	196395022	3	2	8	1	0	0	0	0	1	0	0	0	8131	1299	45	2	2398	2	KCNT2	1	196395022	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	11607131	196395022	52855599	51	1940											
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200801916	200801916	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaattttgccaagaatacttGaaccagtgttgccatttcac	12	13	7	9	0	1	2	1	1	0	1	1	3	1	2	3	0	4	1	3	0	5	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:200801916G>A	uc001gvl.2	+	7	1173	c.903G>A	c.(901-903)TTG>TTA	p.L301L	CAMSAP1L1_uc001gvk.2_Silent_p.L290L|CAMSAP1L1_uc001gvm.2_Silent_p.L290L	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	301	CH.					cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						AAGAATACTTGAACCAGTGTT	0.323													19	74					0	0	0	0	A	200801916	A	A	200801916	2	1	8	1	0	0	0	0	0	0	0	1	2624	1281	45	2		2	CAMSAP1L1	1	200801916	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4406894	200801916	48448705	52	1941											
IRF6	3664	broad.mit.edu	37	chr1	209969798	209969798	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcatacatcaggttgaattCtctgctcttattgagagcac	11	14	7	9	0	4	2	2	2	2	1	5	3	4	2	0	1	3	3	0	1	3	5	rs121434224		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:209969798C>G	uc001hhq.1	-	4	537	c.274G>C	c.(274-276)GAA>CAA	p.E92Q	IRF6_uc010psm.1_5'UTR|IRF6_uc009xct.1_Missense_Mutation_p.E92Q	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	92	IRF tryptophan pentad repeat.				cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		AGGTTGAATTCTCTGCTCTTA	0.532										HNSCC(57;0.16)			21	41					0	0	0	0	G	209969798	G	G	209969798	3	3	8	1	0	0	0	0	1	0	0	0	7873	922	32	2	1153	2	IRF6	1	209969798	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	9167882	209969798	39280823	53	1942											
TATDN3	128387	broad.mit.edu	37	chr1	212977943	212977943	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttatcgttaaacagaaatgTgcactcacgctctgctggaa	12	11	9	9	2	2	1	1	0	1	1	3	2	2	2	0	1	3	5	0	1	5	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:212977943T>C	uc001hjo.2	+	7	531	c.437T>C	c.(436-438)GTG>GCG	p.V146A	TATDN3_uc010ptj.1_Missense_Mutation_p.V146A|TATDN3_uc010ptk.1_Missense_Mutation_p.V146A|TATDN3_uc001hjp.2_Missense_Mutation_p.V146A|TATDN3_uc010ptl.1_Missense_Mutation_p.V125A|TATDN3_uc010ptm.1_Missense_Mutation_p.V94A	NM_001042552	NP_001036017	Q17R31	TATD3_HUMAN	TatD DNase domain containing 3 isoform 1	146						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00699)|all cancers(67;0.0118)|GBM - Glioblastoma multiforme(131;0.0801)|Epithelial(68;0.104)		AACAGAAATGTGCACTCACGC	0.338													6	39					0	0	0	0	C	212977943	C	C	212977943	3	2	8	1	0	0	0	0	1	0	0	0	15659	1696	59	5	463	5	TATDN3	1	212977943	Missense_Mutation	SNP	T	TCGA-BA-5152-01A-02D-1870-08	3008145	212977943	36272678	54	1943											
C1orf124	83932	broad.mit.edu	37	chr1	231489093	231489093	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acagcatcaaagtcaaaagcGaagaaagtctttgaaaaagg	20	6	9	6	1	3	2	2	1	1	1	3	3	3	2	0	1	2	1	0	1	7	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:231489093G>A	uc001hur.2	+	5	1904	c.1456G>A	c.(1456-1458)GAA>AAA	p.E486K	C1orf124_uc001hus.2_3'UTR|C1orf124_uc001hut.2_3'UTR	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	486					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				AGTCAAAAGCGAAGAAAGTCT	0.403													4	34					0	0	0	0	A	231489093	A	A	231489093	3	1	8	1	0	0	0	0	1	0	0	0	2001	1059	37	1	1509	1	C1orf124	1	231489093	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	18511150	231489093	17761528	55	1944											
SIPA1L2	57568	broad.mit.edu	37	chr1	232649741	232649741	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacacctgcatttgtgcagtGagagctgagtgacgattcga	10	10	13	8	2	0	3	0	3	0	1	1	7	0	3	1	0	3	3	1	0	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:232649741G>A	uc001hvg.2	-	1	1503	c.1345C>T	c.(1345-1347)CAC>TAC	p.H449Y		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	449					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTTGTGCAGTGAGAGCTGAGT	0.522													46	142					0	0	0	0	A	232649741	A	A	232649741	3	1	8	1	0	0	0	0	1	0	0	0	14395	1290	45	2	3907	2	SIPA1L2	1	232649741	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1160648	232649741	16600880	56	1945											
OR2L3	391192	broad.mit.edu	37	chr1	248224207	248224207	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgacctaaattacatctccaCcattgttcctaagatggcat	12	13	5	11	0	1	2	0	1	1	1	3	2	2	2	4	1	1	2	4	1	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:248224207C>G	uc001idx.1	+	1	224	c.224C>G	c.(223-225)ACC>AGC	p.T75S	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TACATCTCCACCATTGTTCCT	0.438													48	274					0	0	0	0	G	248224207	G	G	248224207	3	3	8	1	0	0	0	0	1	0	0	0	11062	507	18	4	226	4	OR2L3	1	248224207	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	15574466	248224207	1026414	57	1946											
PGBD2	267002	broad.mit.edu	37	chr1	249211312	249211312	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaatttgagtcttacggctCaggaattgaagtgtgttttg	9	16	11	5	1	3	2	2	2	1	0	3	3	3	3	0	2	1	2	0	2	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:249211312C>T	uc001ifh.2	+	3	676	c.529C>T	c.(529-531)CAG>TAG	p.Q177*	PGBD2_uc001ifg.2_Intron|PGBD2_uc009xhd.2_Nonsense_Mutation_p.Q174*	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	177										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCTTACGGCTCAGGAATTGAA	0.368													20	120					0	0	0	0	T	249211312	T	T	249211312	4	4	8	1	0	0	0	0	0	1	0	0	11836	827	29	2	535	2	PGBD2	1	249211312	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	987105	249211312	39309	58	1947											
RSAD2	91543	broad.mit.edu	37	chr2	7023543	7023543	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggtggagagccatttcttCaagaccggggagaatacctg	11	8	13	9	1	2	3	1	0	1	3	2	5	2	3	3	4	2	0	3	4	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:7023543C>G	uc002qyp.1	+	2	524	c.388C>G	c.(388-390)CAA>GAA	p.Q130E		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	130					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		GCCATTTCTTCAAGACCGGGG	0.453													12	88					0	0	0	0	G	7023543	G	G	7023543	3	3	8	1	0	0	0	0	1	0	0	0	13760	827	29	2	394	2	RSAD2	2	7023543	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		7023543	236175830	59	1948											
ADAM17	6868	broad.mit.edu	37	chr2	9630344	9630344	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgtcaacacgattctgacGctgcagtttaaaggaggcag	11	9	12	9	2	2	1	1	1	1	0	2	3	2	2	0	2	2	5	0	2	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:9630344G>A	uc002qzu.2	-	19	2620	c.2437C>T	c.(2437-2439)CGT>TGT	p.R813C	IAH1_uc010yiz.1_Intron|ADAM17_uc010ewy.2_Missense_Mutation_p.R796C|ADAM17_uc010ewz.2_Missense_Mutation_p.R156C	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	813	Cytoplasmic (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		CGATTCTGACGCTGCAGTTTA	0.438													5	67					0	0	0	0	A	9630344	A	A	9630344	3	1	8	1	0	0	0	0	1	0	0	0	238	1087	38	1	41	1	ADAM17	2	9630344	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2606801	9630344	233569029	60	1949											
TRIB2	28951	broad.mit.edu	37	chr2	12858450	12858450	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcatgaacatacacaggtCtacccccatcacaatagcga	15	7	5	14	1	3	1	2	1	1	0	3	2	3	1	2	1	4	0	2	1	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:12858450C>G	uc002rbv.3	+	1	1453	c.17C>G	c.(16-18)TCT>TGT	p.S6C	TRIB2_uc010yjp.1_Intron	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	6					negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ATACACAGGTCTACCCCCATC	0.537											OREG0014450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	62					0	0	0	0	G	12858450	G	G	12858450	3	3	8	1	0	0	0	0	1	0	0	0	16550	913	32	2	19	2	TRIB2	2	12858450	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3228106	12858450	230340923	61	1950											
APOB	338	broad.mit.edu	37	chr2	21226113	21226113	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagcaagccagaagctgcctCttcttcccaattaactttga	11	12	6	12	0	2	2	0	1	2	1	3	2	3	2	3	0	5	2	3	0	5	5	rs121918385		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:21226113C>T	uc002red.2	-	29	12309	c.12181G>A	c.(12181-12183)GAG>AAG	p.E4061K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4061					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GAAGCTGCCTCTTCTTCCCAA	0.453													107	295					0	0	0	0	T	21226113	T	T	21226113	3	4	8	1	0	0	0	0	1	0	0	0	785	922	32	2	1514	2	APOB	2	21226113	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	8367663	21226113	221973260	62	1951											
ATAD2B	54454	broad.mit.edu	37	chr2	23980730	23980730	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcccctggtccaagtccatGatgtcacaggatgattcatc	9	11	9	12	0	2	2	2	2	0	0	5	3	4	3	4	2	1	0	4	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:23980730G>A	uc002rek.3	-	25	3930	c.3636C>T	c.(3634-3636)ATC>ATT	p.I1212I	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Silent_p.I452I|ATAD2B_uc002rej.3_Silent_p.I380I	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1212							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAAGTCCATGATGTCACAGG	0.443													31	101					0	0	0	0	A	23980730	A	A	23980730	2	1	8	1	0	0	0	0	0	0	0	1	1074	1280	45	2		2	ATAD2B	2	23980730	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2754617	23980730	219218643	63	1952											
C2orf44	80304	broad.mit.edu	37	chr2	24255769	24255769	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccttagtttaccatcacaGagaagcaccgctcttttttc	10	13	6	12	1	2	1	1	0	1	1	3	2	2	1	3	0	3	3	3	0	3	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:24255769G>A	uc002rep.2	-	3	1997	c.1866C>T	c.(1864-1866)CTC>CTT	p.L622L	C2orf44_uc010eya.2_Intron	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	622							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACCATCACAGAGAAGCACCG	0.383													46	151					0	0	0	0	A	24255769	A	A	24255769	2	1	8	1	0	0	0	0	0	0	0	1	2178	929	33	2		2	C2orf44	2	24255769	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	275039	24255769	218943604	64	1953											
TMEM214	54867	broad.mit.edu	37	chr2	27263361	27263361	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagcactgccatgaggcatGcaggtgagacctttgcccag	9	7	14	11	0	0	2	0	2	0	1	0	4	0	3	3	3	4	3	3	3	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:27263361G>A	uc002ria.3	+	16	2050	c.1940G>A	c.(1939-1941)TGC>TAC	p.C647Y	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Missense_Mutation_p.C602Y	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	647						integral to membrane	protein binding				0						CATGAGGCATGCAGGTGAGAC	0.637													5	56					0	0	0	0	A	27263361	A	A	27263361	3	1	8	1	0	0	0	0	1	0	0	0	16203	1319	46	4	2002	4	TMEM214	2	27263361	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3007592	27263361	215936012	65	1954											
GTF3C2	2976	broad.mit.edu	37	chr2	27566224	27566224	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctctggagggagcctcctCtgatcaggagaatcctcaaa	10	9	11	11	0	4	2	2	1	2	1	6	5	6	4	3	3	2	1	3	3	2	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:27566224C>G	uc002rjv.1	-	3	561	c.198G>C	c.(196-198)CAG>CAC	p.Q66H	GTF3C2_uc002rju.1_Missense_Mutation_p.Q77H|GTF3C2_uc002rjw.1_Missense_Mutation_p.Q66H|GTF3C2_uc010eyz.1_Missense_Mutation_p.Q66H	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	66						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGCCTCCTCTGATCAGGAG	0.488													9	282					0	0	0	0	G	27566224	G	G	27566224	3	3	8	1	0	0	0	0	1	0	0	0	6912	912	32	2	2609	2	GTF3C2	2	27566224	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	302863	27566224	215633149	66	1955			1	3		4	4	78	C		5.293724e-10
GTF3C2	2976	broad.mit.edu	37	chr2	27566241	27566241	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctgatcaggagaatcctCaaatccaggcaaaggggtag	13	7	11	10	0	3	2	2	1	1	1	5	3	5	2	3	4	0	2	3	4	4	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:27566241C>G	uc002rjv.1	-	3	544	c.181G>C	c.(181-183)GAG>CAG	p.E61Q	GTF3C2_uc002rju.1_Missense_Mutation_p.E72Q|GTF3C2_uc002rjw.1_Missense_Mutation_p.E61Q|GTF3C2_uc010eyz.1_Missense_Mutation_p.E61Q	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	61						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGAATCCTCAAATCCAGGC	0.488													5	260					0	0	0	0	G	27566241	G	G	27566241	3	3	8	1	0	0	0	0	1	0	0	0	6912	835	29	2	2626	2	GTF3C2	2	27566241	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	17	27566241	215633132	67	1956			1	3		4	4	78	C		5.293724e-10
GTF3C2	2976	broad.mit.edu	37	chr2	27566274	27566274	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggggtaggtaatgacatctCtacggaagcctctgcactgg	10	9	13	9	1	2	1	0	1	2	0	3	2	2	2	1	5	3	3	1	5	4	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:27566274C>G	uc002rjv.1	-	3	511	c.148G>C	c.(148-150)GAG>CAG	p.E50Q	GTF3C2_uc002rju.1_Missense_Mutation_p.E61Q|GTF3C2_uc002rjw.1_Missense_Mutation_p.E50Q|GTF3C2_uc010eyz.1_Missense_Mutation_p.E50Q	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	50						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATGACATCTCTACGGAAGCC	0.522													5	254					0	0	0	0	G	27566274	G	G	27566274	3	3	8	1	0	0	0	0	1	0	0	0	6912	922	32	2	2659	2	GTF3C2	2	27566274	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	33	27566274	215633099	68	1957			1	3		4	4	78	C		5.293724e-10
GTF3C2	2976	broad.mit.edu	37	chr2	27566301	27566301	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctctgcactggtcatttCtgaagaggtcttgacatcaa	10	12	9	10	0	5	3	2	2	3	1	5	3	5	3	1	2	2	1	1	2	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:27566301C>A	uc002rjv.1	-	3	484	c.121G>T	c.(121-123)GAA>TAA	p.E41*	GTF3C2_uc002rju.1_Nonsense_Mutation_p.E52*|GTF3C2_uc002rjw.1_Nonsense_Mutation_p.E41*|GTF3C2_uc010eyz.1_Nonsense_Mutation_p.E41*	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	41						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGTCATTTCTGAAGAGGTC	0.542													6	239					2.52707e-12	2.67771e-12	1	0	A	27566301	A	A	27566301	4	1	8	1	0	0	0	0	0	1	0	0	6912	922	32	2	2686	2	GTF3C2	2	27566301	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	27	27566301	215633072	69	1958			1	3		4	4	78	C		5.293724e-10
SPDYA	245711	broad.mit.edu	37	chr2	29063067	29063067	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgcaccaacccattatatCtggcaaagagaacgttctgt	13	11	7	10	1	2	1	0	0	2	1	2	2	2	1	2	1	3	3	2	1	5	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:29063067C>T	uc002rmj.2	+	7	788	c.582C>T	c.(580-582)ATC>ATT	p.I194I	SPDYA_uc002rmi.2_Silent_p.I194I|SPDYA_uc002rmk.2_Silent_p.I194I|SPDYA_uc002rml.2_Silent_p.I194I	NM_182756	NP_877433	Q5MJ70	SPDYA_HUMAN	speedy homolog A isoform 1	194	Speedy/Ringo box; Required for CDK- binding (By similarity).				G1/S transition of mitotic cell cycle|multicellular organismal development|positive regulation of cell proliferation|response to DNA damage stimulus	nucleus	protein kinase binding			upper_aerodigestive_tract(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					CCCATTATATCTGGCAAAGAG	0.378													7	37					0	0	0	0	T	29063067	T	T	29063067	2	4	8	1	0	0	0	0	0	0	0	1	15093	903	32	2		2	SPDYA	2	29063067	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1496766	29063067	214136306	70	1959											
C2orf71	388939	broad.mit.edu	37	chr2	29294902	29294902	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccccagcatcctcagactCtccgtgggactgaaagtttc	8	10	8	15	1	2	2	1	1	1	1	6	3	4	3	4	1	1	2	4	1	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:29294902C>T	uc002rmt.1	-	1	2226	c.2226G>A	c.(2224-2226)GAG>GAA	p.E742E		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	742					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						TCCTCAGACTCTCCGTGGGAC	0.562													27	65					0	0	0	0	T	29294902	T	T	29294902	2	4	8	1	0	0	0	0	0	0	0	1	2201	912	32	2		2	C2orf71	2	29294902	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	231835	29294902	213904471	71	1960											
XDH	7498	broad.mit.edu	37	chr2	31598258	31598258	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccactcacgtcttccaggttCtcttggcccagcttctgaag	6	12	8	15	1	4	1	1	1	3	0	6	1	5	1	3	2	1	2	3	2	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:31598258C>T	uc002rnv.1	-	15	1669	c.1590G>A	c.(1588-1590)GAG>GAA	p.E530E		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	530					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CTTCCAGGTTCTCTTGGCCCA	0.552													39	120					0	0	0	0	T	31598258	T	T	31598258	2	4	8	1	0	0	0	0	0	0	0	1	17494	912	32	2		2	XDH	2	31598258	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2303356	31598258	211601115	72	1961											
CCDC75	253635	broad.mit.edu	37	chr2	37319076	37319076	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagggaaaagtggcattggtCatgaggcatcattaaaacgg	14	9	13	5	1	2	1	2	1	0	0	2	2	2	2	0	5	1	2	0	5	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:37319076C>T	uc010ezz.2	+	5	479	c.334C>T	c.(334-336)CAT>TAT	p.H112Y	CCDC75_uc002rpr.3_Missense_Mutation_p.H9Y	NM_174931	NP_777591	Q8N954	CCD75_HUMAN	coiled-coil domain containing 75	112	G-patch.					intracellular	nucleic acid binding				0		all_hematologic(82;0.21)				TGGCATTGGTCATGAGGCATC	0.348													9	36					0	0	0	0	T	37319076	T	T	37319076	3	4	8	1	0	0	0	0	1	0	0	0	2862	826	29	2	348	2	CCDC75	2	37319076	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5720818	37319076	205880297	73	1962											
CDKL4	344387	broad.mit.edu	37	chr2	39406448	39406448	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttaatctgtcatctggattCatcttcagacacccctttgg	8	15	7	11	0	6	1	3	0	3	1	6	2	6	2	2	2	0	1	2	2	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:39406448C>T	uc002rrm.2	-	8	807	c.807G>A	c.(805-807)ATG>ATA	p.M269I	CDKL4_uc010fal.1_Missense_Mutation_p.M269I	NM_001009565	NP_001009565	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4	269	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			ovary(1)	1		all_hematologic(82;0.248)				CATCTGGATTCATCTTCAGAC	0.423													14	90					0	0	0	0	T	39406448	T	T	39406448	3	4	8	1	0	0	0	0	1	0	0	0	3171	826	29	2	144	2	CDKL4	2	39406448	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2087372	39406448	203792925	74	1963											
LOC728819	728819	broad.mit.edu	37	chr2	43902889	43902889	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtctgttaagtcttttcatCaactctctgcttaagacaat	11	16	5	9	0	5	1	2	0	3	1	6	1	5	1	0	0	2	2	0	0	4	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:43902889C>T	uc010fav.1	-	1	573	c.573G>A	c.(571-573)TTG>TTA	p.L191L	PLEKHH2_uc002rte.3_Intron|PLEKHH2_uc002rtf.3_Intron|PLEKHH2_uc010yny.1_Intron	NM_001101330	NP_001094800			C1GALT1-specific chaperone 1-like												0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTCTTTTCATCAACTCTCTGC	0.448													53	167					0	0	0	0	T	43902889	T	T	43902889	2	4	8	1	0	0	0	0	0	0	0	1	8937	825	29	2		2	LOC728819	2	43902889	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4496441	43902889	199296484	75	1964											
SIX3	6496	broad.mit.edu	37	chr2	45169452	45169453	+	Missense_Mutation	DNP	CC	AT	AT																															cggcggcggcggcggcggctCcagggcccccccggaagagt																										TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:45169452_45169453CC>AT	uc002run.1	+	1	416_417	c.209_210CC>AT	c.(208-210)TCC>TAT	p.S70Y		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	70					visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ggcggcggcTCCAGGGCCCCCC	0.342													4	9					0	0	0	0	AT	45169453	AT	AT	45169452	3	1	8	1	0	0	0	0	1	0	0	0	14413	855	30	2	211	2	SIX3	2	45169452	Missense_Mutation	DNP	CC	TCGA-BA-5152-01A-02D-1870-08	1266563	45169452	198029921	76	1965											
RHOQ	23433	broad.mit.edu	37	chr2	46770215	46770215	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcccggcgcgctgatgctCaagtgcgtggtggtcggcga	4	7	19	11	6	1	1	1	1	0	0	2	2	1	1	1	5	2	2	1	5	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:46770215C>T	uc002rva.2	+	1	349	c.30C>T	c.(28-30)CTC>CTT	p.L10L	ATP6V1E2_uc002ruz.2_5'Flank	NM_012249	NP_036381	P17081	RHOQ_HUMAN	ras-like protein TC10 precursor	10					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CGCTGATGCTCAAGTGCGTGG	0.587													6	49					0	0	0	0	T	46770215	T	T	46770215	2	4	8	1	0	0	0	0	0	0	0	1	13407	813	29	2		2	RHOQ	2	46770215	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1600763	46770215	196429158	77	1966											
SOCS5	9655	broad.mit.edu	37	chr2	46986870	46986870	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctcgaagggaaacctgaaGgcacgtttttgctcagggac	10	10	12	9	2	2	1	1	1	1	0	3	4	2	3	1	3	2	3	1	3	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:46986870G>T	uc002rvf.2	+	2	1365	c.1201G>T	c.(1201-1203)GGC>TGC	p.G401C	SOCS5_uc010yoe.1_Missense_Mutation_p.G370C|SOCS5_uc002rvg.2_Missense_Mutation_p.G401C	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	401	SH2.				cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GAAACCTGAAGGCACGTTTTT	0.527													26	78					7.92952e-12	8.37725e-12	1	0	T	46986870	T	T	46986870	3	4	8	1	0	0	0	0	1	0	0	0	14981	1000	35	4	1203	4	SOCS5	2	46986870	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	216655	46986870	196212503	78	1967											
FBXO11	80204	broad.mit.edu	37	chr2	48063095	48063095	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aattttccaggttcaggatgCatcatagggcgagtatattc	11	13	10	7	1	2	0	2	0	0	0	4	2	3	1	1	3	1	3	1	3	4	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:48063095C>T	uc010fbl.2	-	5	495	c.381G>A	c.(379-381)ATG>ATA	p.M127I	FBXO11_uc002rwe.2_Missense_Mutation_p.M127I|FBXO11_uc002rwf.2_Missense_Mutation_p.M127I|FBXO11_uc002rwg.1_Missense_Mutation_p.M127I	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	211					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GTTCAGGATGCATCATAGGGC	0.328													7	54					0	0	0	0	T	48063095	T	T	48063095	3	4	8	1	0	0	0	0	1	0	0	0	5759	710	25	4	2316	4	FBXO11	2	48063095	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1076225	48063095	195136278	79	1968											
SPTBN1	6711	broad.mit.edu	37	chr2	54852072	54852072	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctatgagggagacttggctGagcgaaaaccagcgtctggt	10	8	15	8	2	1	3	0	2	1	1	1	5	1	3	1	3	3	2	1	3	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:54852072G>A	uc002rxu.2	+	11	1563	c.1314G>A	c.(1312-1314)CTG>CTA	p.L438L	SPTBN1_uc002rxv.1_Silent_p.L438L|SPTBN1_uc002rxx.2_Silent_p.L425L	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	438	Spectrin 2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGACTTGGCTGAGCGAAAACC	0.488													6	102					0	0	0	0	A	54852072	A	A	54852072	2	1	8	1	0	0	0	0	0	0	0	1	15185	1277	45	2		2	SPTBN1	2	54852072	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	6788977	54852072	188347301	80	1969											
MTIF2	4528	broad.mit.edu	37	chr2	55471167	55471167	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaattaagcttgatacacctCagattctacttcaagaattt	14	14	5	8	0	3	3	2	1	1	2	3	4	3	3	1	0	3	1	1	0	6	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:55471167C>G	uc002ryn.2	-	12	2046	c.1309G>C	c.(1309-1311)GAG>CAG	p.E437Q	MTIF2_uc010yox.1_Missense_Mutation_p.E106Q|MTIF2_uc002ryo.2_Missense_Mutation_p.E437Q	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	437					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						TGATACACCTCAGATTCTACT	0.338													7	31					0	0	0	0	G	55471167	G	G	55471167	3	3	8	1	0	0	0	0	1	0	0	0	9987	835	29	2	898	2	MTIF2	2	55471167	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	619095	55471167	187728206	81	1970											
CCDC104	112942	broad.mit.edu	37	chr2	55747049	55747049	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actttgtggaacagaaatgtGaaggtaaaaaccagagcccg	16	7	11	7	1	0	3	0	1	0	2	0	4	0	4	2	2	3	1	2	2	6	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:55747049G>A	uc002ryy.2	+	1	310	c.112G>A	c.(112-114)GAA>AAA	p.E38K	CCDC104_uc002ryx.2_Missense_Mutation_p.E38K	NM_080667	NP_542398	Q96G28	CC104_HUMAN	coiled-coil domain containing 104	38										ovary(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACAGAAATGTGAAGGTAAAAA	0.567													26	50					0	0	0	0	A	55747049	A	A	55747049	3	1	8	1	0	0	0	0	1	0	0	0	2751	1291	45	2	114	2	CCDC104	2	55747049	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	275882	55747049	187452324	82	1971											
ETAA1	54465	broad.mit.edu	37	chr2	67630409	67630409	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaactggctaaacaatttGataaaaatatggaagagcta	19	10	8	4	0	0	3	0	2	0	1	0	4	0	4	0	2	3	2	0	2	10	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:67630409G>C	uc002sdz.1	+	5	734	c.595G>C	c.(595-597)GAT>CAT	p.D199H		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	199	Potential.					cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						TAAACAATTTGATAAAAATAT	0.259													29	65					0	0	0	0	C	67630409	C	C	67630409	3	2	8	1	0	0	0	0	1	0	0	0	5291	1290	45	2	613	2	ETAA1	2	67630409	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	11883360	67630409	175568964	83	1972											
CLEC4F	165530	broad.mit.edu	37	chr2	71043679	71043679	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcagcattggctccttcCaaactatttcttaaaacctg	11	14	4	12	0	2	0	1	0	2	0	5	0	4	0	3	1	3	2	3	1	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:71043679C>A	uc002shf.2	-	4	911	c.834G>T	c.(832-834)TTG>TTT	p.L278F	CLEC4F_uc010yqv.1_Missense_Mutation_p.L278F	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	278	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						TGGCTCCTTCCAAACTATTTC	0.408													32	114					3.99451e-17	4.26441e-17	1	0	A	71043679	A	A	71043679	3	1	8	1	0	0	0	0	1	0	0	0	3531	593	21	4	951	4	CLEC4F	2	71043679	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3413270	71043679	172155694	84	1973											
RAB11FIP5	26056	broad.mit.edu	37	chr2	73303223	73303223	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcttctccagcccactgctCagggctatgctcagactgga	8	9	10	14	0	3	1	2	0	1	1	4	2	3	2	2	2	4	4	2	2	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:73303223C>T	uc002siu.3	-	4	1897	c.1656G>A	c.(1654-1656)CTG>CTA	p.L552L	RAB11FIP5_uc002sis.3_5'UTR|RAB11FIP5_uc002sit.3_Silent_p.L474L	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	552					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GCCCACTGCTCAGGGCTATGC	0.622													27	261					0	0	0	0	T	73303223	T	T	73303223	2	4	8	1	0	0	0	0	0	0	0	1	12962	813	29	2		2	RAB11FIP5	2	73303223	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2259544	73303223	169896150	85	1974											
RAB11FIP5	26056	broad.mit.edu	37	chr2	73339833	73339833	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcccgcgggcccgcagcaCcgtcacctggacgtgcgtgg	5	4	15	17	6	1	0	1	0	0	0	1	1	1	1	4	3	3	2	4	3	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:73339833C>T	uc002siu.3	-	1	314	c.73G>A	c.(73-75)GTG>ATG	p.V25M		NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	25	C2.				protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GCCCGCAGCACCGTCACCTGG	0.751													3	3					0	0	0	0	T	73339833	T	T	73339833	3	4	8	1	0	0	0	0	1	0	0	0	12962	507	18	4	1908	4	RAB11FIP5	2	73339833	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	36610	73339833	169859540	86	1975											
TPRKB	51002	broad.mit.edu	37	chr2	73959362	73959362	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatttttcccagtttgtaGaggtgaactgctttgtttgc	6	19	9	7	0	1	2	1	1	0	1	2	2	2	2	1	1	3	4	1	1	2	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:73959362G>C	uc002sjn.2	-	3	303	c.192C>G	c.(190-192)CTC>CTG	p.L64L	TPRKB_uc002sjm.2_Silent_p.L103L|TPRKB_uc002sjl.2_Silent_p.L31L|TPRKB_uc002sjo.2_Silent_p.L64L|TPRKB_uc010yrm.1_Silent_p.L31L	NM_016058	NP_057142	Q9Y3C4	TPRKB_HUMAN	TP53RK binding protein	64					protein catabolic process	cytosol|nucleus	protein kinase binding			ovary(1)|skin(1)	2						CCAGTTTGTAGAGGTGAACTG	0.358													23	52					0	0	0	0	C	73959362	C	C	73959362	2	2	8	1	0	0	0	0	0	0	0	1	16487	929	33	2		2	TPRKB	2	73959362	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	619529	73959362	169240011	87	1976											
RTKN	6242	broad.mit.edu	37	chr2	74657432	74657432	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggtcctgtccactaggatCatctctgtgtcctggatgtg	6	13	12	10	0	2	0	1	0	1	0	6	2	5	2	3	3	0	0	3	3	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:74657432C>T	uc002sle.2	-	5	609	c.492G>A	c.(490-492)ATG>ATA	p.M164I	RTKN_uc002slc.2_Missense_Mutation_p.M151I|RTKN_uc002sld.2_Missense_Mutation_p.M114I	NM_001015055	NP_001015055	Q9BST9	RTKN_HUMAN	rhotekin isoform a	164					apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1						CCACTAGGATCATCTCTGTGT	0.547													7	36					0	0	0	0	T	74657432	T	T	74657432	3	4	8	1	0	0	0	0	1	0	0	0	13787	826	29	2	1231	2	RTKN	2	74657432	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	698070	74657432	168541941	88	1977											
C2orf3	6936	broad.mit.edu	37	chr2	75929407	75929407	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatggtcatcaggctcactCtcagggtcatcttcgctctc	6	13	8	14	1	8	0	6	0	3	0	11	0	8	0	0	3	0	2	0	3	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:75929407C>G	uc002sno.2	-	3	667	c.537G>C	c.(535-537)GAG>GAC	p.E179D	C2orf3_uc010ffs.2_5'Flank|C2orf3_uc002snn.2_Missense_Mutation_p.E10D|C2orf3_uc010fft.2_5'UTR|C2orf3_uc002snp.3_Missense_Mutation_p.E179D	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	179					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						CAGGCTCACTCTCAGGGTCAT	0.423													40	120					0	0	0	0	G	75929407	G	G	75929407	3	3	8	1	0	0	0	0	1	0	0	0	2172	912	32	2	1868	2	C2orf3	2	75929407	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1271975	75929407	167269966	89	1978											
LRRTM4	80059	broad.mit.edu	37	chr2	76975904	76975904	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gctgtggtctcggcccagctCcaggccggggctttcgtcct	2	10	14	15	3	1	0	0	0	1	0	5	0	3	0	4	5	1	3	4	5	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:76975904C>G	uc002snr.2	-	4	2105	c.1690G>C	c.(1690-1692)GAG>CAG	p.E564Q	LRRTM4_uc002snq.2_Missense_Mutation_p.E564Q	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	564	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CGGCCCAGCTCCAGGCCGGGG	0.602													32	121					0	0	0	0	G	76975904	G	G	76975904	3	3	8	1	0	0	0	0	1	0	0	0	9092	864	30	2	86	2	LRRTM4	2	76975904	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1046497	76975904	166223469	90	1979											
ZNF514	84874	broad.mit.edu	37	chr2	95815860	95815860	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgttttatctgctgcatctCtaactggccatcacaaccgc	8	13	6	14	1	3	0	1	0	2	0	4	0	3	0	2	1	4	3	2	1	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:95815860C>T	uc002sue.1	-	5	744	c.370G>A	c.(370-372)GAG>AAG	p.E124K	ZNF514_uc002sud.1_Missense_Mutation_p.E197K	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCTGCATCTCTAACTGGCCA	0.423													40	82					0	0	0	0	T	95815860	T	T	95815860	3	4	8	1	0	0	0	0	1	0	0	0	18026	922	32	2	836	2	ZNF514	2	95815860	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	18839956	95815860	147383513	91	1980											
ZNF514	84874	broad.mit.edu	37	chr2	95818421	95818421	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcactcactcactcacctGagtgggctcctgttgagatt	7	14	8	12	0	4	2	4	2	0	1	5	3	5	2	2	1	0	2	2	1	0	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:95818421G>A	uc002sue.1	-	4	589	c.215C>T	c.(214-216)TCA>TTA	p.S72L	ZNF514_uc002sud.1_Missense_Mutation_p.S145L	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	72	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCACTCACCTGAGTGGGCTCC	0.522													54	150					0	0	0	0	A	95818421	A	A	95818421	3	1	8	1	0	0	0	0	1	0	0	0	18026	1294	45	2	995	2	ZNF514	2	95818421	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2561	95818421	147380952	92	1981											
FER1L5	90342	broad.mit.edu	37	chr2	97361634	97361634	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caagactatatgcacccaaaGcttccaagtacggcccttcc	12	8	6	15	1	0	1	0	0	0	1	2	1	2	1	4	1	3	3	4	1	6	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:97361634G>C	uc010fia.2	+	35	4131	c.4131G>C	c.(4129-4131)AAG>AAC	p.K1377N	FER1L5_uc002sws.3_Missense_Mutation_p.K95N|FER1L5_uc010fib.1_RNA|FER1L5_uc002swt.3_Missense_Mutation_p.K95N|FER1L5_uc010yus.1_Missense_Mutation_p.K94N	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1377						integral to membrane				ovary(1)	1						TGCACCCAAAGCTTCCAAGTA	0.632													6	29					0	0	0	0	C	97361634	C	C	97361634	3	2	8	1	0	0	0	0	1	0	0	0	5846	962	34	4	4269	4	FER1L5	2	97361634	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1543213	97361634	145837739	93	1982											
ZC3H8	84524	broad.mit.edu	37	chr2	112989456	112989456	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaggagtcagtggagcatGagaaaacttgcagtattctc	12	11	11	7	0	3	1	2	1	1	1	4	4	3	3	0	2	3	3	0	2	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:112989456G>A	uc002thp.2	-	7	908	c.802C>T	c.(802-804)CAT>TAT	p.H268Y		NM_032494	NP_115883	Q8N5P1	ZC3H8_HUMAN	zinc finger CCCH-type containing 8	268	C3H1-type 3.				apoptosis|negative regulation of T cell differentiation in thymus|negative regulation of transcription, DNA-dependent|positive regulation of thymocyte apoptosis|response to antibiotic|T cell homeostasis	nucleus	RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGTGGAGCATGAGAAAACTTG	0.303													20	81					0	0	0	0	A	112989456	A	A	112989456	3	1	8	1	0	0	0	0	1	0	0	0	17641	1290	45	2	81	2	ZC3H8	2	112989456	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	15627822	112989456	130209917	94	1983											
POLR1B	84172	broad.mit.edu	37	chr2	113322029	113322029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtgtcatggttggctgggtgGataaggatcttgctccaggc	6	12	16	7	0	2	0	1	0	1	0	3	2	3	2	1	6	1	3	1	6	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:113322029G>C	uc002thw.2	+	10	2279	c.1699G>C	c.(1699-1701)GAT>CAT	p.D567H	POLR1B_uc010fkn.2_Missense_Mutation_p.D511H|POLR1B_uc002thx.2_Missense_Mutation_p.D428H|POLR1B_uc010fko.2_Intron|POLR1B_uc010fkp.2_Missense_Mutation_p.D6H|POLR1B_uc010yxn.1_Missense_Mutation_p.D605H|POLR1B_uc002thy.2_Missense_Mutation_p.D428H|POLR1B_uc010yxo.1_Missense_Mutation_p.D344H	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	567					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						TGGCTGGGTGGATAAGGATCT	0.507													42	212					0	0	0	0	C	113322029	C	C	113322029	3	2	8	1	0	0	0	0	1	0	0	0	12265	1174	41	2	1737	2	POLR1B	2	113322029	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	332573	113322029	129877344	95	1984											
KYNU	8942	broad.mit.edu	37	chr2	143790866	143790866	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatcctcccattttgttggtCtgttccttgcatgctagttt	5	19	7	10	0	1	0	0	0	1	0	4	0	4	0	3	1	2	5	3	1	2	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:143790866C>G	uc002tvl.2	+	12	1147	c.1017C>G	c.(1015-1017)GTC>GTG	p.V339V	KYNU_uc010fnm.2_Silent_p.V339V	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	339					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTTTGTTGGTCTGTTCCTTGC	0.378													10	179					0	0	0	0	G	143790866	G	G	143790866	2	3	8	1	0	0	0	0	0	0	0	1	8627	900	32	2		2	KYNU	2	143790866	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	30468837	143790866	99408507	96	1985											
LRP2	4036	broad.mit.edu	37	chr2	170115654	170115654	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatgagagtctgtccaataGagattctttgaaatccaatc	14	13	7	7	0	2	3	0	2	2	2	5	5	4	3	2	0	0	0	2	0	5	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:170115654G>T	uc002ues.2	-	17	2607	c.2394C>A	c.(2392-2394)CTC>CTA	p.L798L	LRP2_uc010zdf.1_Silent_p.L661L	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	798	LDL-receptor class B 7.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTGTCCAATAGAGATTCTTTG	0.378													38	66					2.05212e-20	2.20069e-20	1	0	T	170115654	T	T	170115654	2	4	8	1	0	0	0	0	0	0	0	1	9006	929	33	2		2	LRP2	2	170115654	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	26324788	170115654	73083719	97	1986											
HAT1	8520	broad.mit.edu	37	chr2	172822934	172822934	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgttttatctgcagatttGagaagtataataaggatgga	13	15	10	3	0	2	2	0	1	2	2	2	5	2	4	0	2	1	3	0	2	5	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:172822934G>C	uc002uhi.2	+	7	692	c.616G>C	c.(616-618)GAG>CAG	p.E206Q	HAT1_uc010fqi.2_Missense_Mutation_p.E41Q|HAT1_uc002uhj.2_Missense_Mutation_p.E121Q	NM_003642	NP_003633	O14929	HAT1_HUMAN	histone acetyltransferase 1	206					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CTGCAGATTTGAGAAGTATAA	0.438													3	40					0	0	0	0	C	172822934	C	C	172822934	3	2	8	1	0	0	0	0	1	0	0	0	7003	1291	45	2	642	2	HAT1	2	172822934	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2707280	172822934	70376439	98	1987											
EVX2	344191	broad.mit.edu	37	chr2	176948129	176948129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgaggcccccgggggagcGaagcgcggagcagcccacct	7	1	17	16	5	0	0	0	0	0	0	0	4	0	2	5	4	4	1	5	4	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:176948129G>A	uc010zeu.1	-	1	562	c.376C>T	c.(376-378)CGC>TGC	p.R126C		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	126						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CCGGGGGAGCGAAGCGCGGAG	0.682													6	13					0	0	0	0	A	176948129	A	A	176948129	3	1	8	1	0	0	0	0	1	0	0	0	5319	1058	37	1	1064	1	EVX2	2	176948129	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4125195	176948129	66251244	99	1988											
TTC30B	150737	broad.mit.edu	37	chr2	178415907	178415907	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcatcataagagagctgctCttcctccttttcaatcttcc	8	15	5	13	0	5	1	3	0	2	1	8	2	8	1	3	0	2	2	3	0	2	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:178415907C>G	uc002uln.2	-	1	1618	c.1585G>C	c.(1585-1587)GAG>CAG	p.E529Q	TTC30B_uc010zfc.1_Missense_Mutation_p.E301Q	NM_152517	NP_689730	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	529	Potential.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			GAGAGCTGCTCTTCCTCCTTT	0.378													64	143					0	0	0	0	G	178415907	G	G	178415907	3	3	8	1	0	0	0	0	1	0	0	0	16767	922	32	2	416	2	TTC30B	2	178415907	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1467778	178415907	64783466	100	1989											
TTN	7273	broad.mit.edu	37	chr2	179428814	179428814	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaacattgctgagtttcaGaatatattgtcctccatcag	12	13	6	10	0	2	2	2	1	0	1	4	2	4	2	3	0	2	2	3	0	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:179428814G>C	uc010zfg.1	-	275	74565	c.74341C>G	c.(74341-74343)CTG>GTG	p.L24781V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L18476V|TTN_uc010zfi.1_Missense_Mutation_p.L18409V|TTN_uc010zfj.1_Missense_Mutation_p.L18284V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25708							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAGTTTCAGAATATATTGT	0.413													29	173					0	0	0	0	C	179428814	C	C	179428814	3	2	8	1	0	0	0	0	1	0	0	0	16803	933	33	2	26082	2	TTN	2	179428814	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1012907	179428814	63770559	101	1990											
TTN	7273	broad.mit.edu	37	chr2	179572396	179572396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgaagctgcatctgtctGaaggctttatttccctgcca	8	13	9	11	0	2	2	0	2	2	0	3	2	3	2	2	1	4	4	2	1	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:179572396G>A	uc010zfg.1	-	97	25390	c.25166C>T	c.(25165-25167)TCA>TTA	p.S8389L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S5050L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9316							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCATCTGTCTGAAGGCTTTAT	0.483													18	36					0	0	0	0	A	179572396	A	A	179572396	3	1	8	1	0	0	0	0	1	0	0	0	16803	1294	45	2	75683	2	TTN	2	179572396	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	143582	179572396	63626977	102	1991											
TTN	7273	broad.mit.edu	37	chr2	179611231	179611231	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaggtgttcttgatgatgtgGtgtgttccaaatcaaactcc	10	14	10	7	0	2	2	1	2	1	0	4	2	4	2	2	2	1	2	2	2	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:179611231G>A	uc002unb.2	-	46	16120	c.15896C>T	c.(15895-15897)ACC>ATC	p.T5299I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	8817							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATGATGTGGTGTGTTCCAA	0.408													13	34					0	0	0	0	A	179611231	A	A	179611231	3	1	8	1	0	0	0	0	1	0	0	0	16803	1261	44	4	94401	4	TTN	2	179611231	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	38835	179611231	63588142	103	1992											
CFLAR	8837	broad.mit.edu	37	chr2	202025553	202025553	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctgtgcacagttcaccgaGaagctgacttcttctggagc	8	10	12	11	1	3	2	1	1	2	1	3	4	3	3	1	2	3	4	1	2	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:202025553G>A	uc002uxb.3	+	9	1644	c.1192G>A	c.(1192-1194)GAA>AAA	p.E398K	CFLAR_uc010zhk.1_Missense_Mutation_p.E302K|CFLAR_uc002uxc.3_Missense_Mutation_p.E363K|CFLAR_uc010zhl.1_Missense_Mutation_p.E302K|CFLAR_uc010fsw.1_RNA|CFLAR_uc002uxd.3_Missense_Mutation_p.E398K|CFLAR_uc002uxf.2_Missense_Mutation_p.E398K|CFLAR_uc010fsy.2_RNA|CFLAR_uc010fsx.2_Intron|CFLAR_uc010zhm.1_Missense_Mutation_p.E302K|CFLAR_uc010fsz.2_Missense_Mutation_p.E153K|CFLAR_uc002uxg.2_Missense_Mutation_p.E153K	NM_003879	NP_003870	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator isoform	398	Interaction with caspase-8.|Interaction with caspase-3.|Interaction with TRAF1 and TRAF2.|Not proteolytically processed and involved in apoptosis inhibition.|Interaction with caspase-8 subunits p18 and p10.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding				0						AGTTCACCGAGAAGCTGACTT	0.577													15	33					0	0	0	0	A	202025553	A	A	202025553	3	1	8	1	0	0	0	0	1	0	0	0	3307	943	33	2	1286	2	CFLAR	2	202025553	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	22414322	202025553	41173820	104	1993											
ALS2	57679	broad.mit.edu	37	chr2	202625889	202625889	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggtttcagtggaggggctGagagcagtgctggcatggtt	7	10	19	5	0	1	1	1	1	0	1	1	3	1	2	0	6	2	6	0	6	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:202625889G>A	uc002uyo.2	-	4	1184	c.828C>T	c.(826-828)CTC>CTT	p.L276L	ALS2_uc002uyp.3_Silent_p.L276L|ALS2_uc002uyq.2_Silent_p.L276L|ALS2_uc002uyr.2_Silent_p.L276L	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	276					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TGGAGGGGCTGAGAGCAGTGC	0.453													22	46					0	0	0	0	A	202625889	A	A	202625889	2	1	8	1	0	0	0	0	0	0	0	1	550	1277	45	2		2	ALS2	2	202625889	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	600336	202625889	40573484	105	1994											
C2orf62	375307	broad.mit.edu	37	chr2	219222441	219222441	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcttggacaaaatgctctgCggaaattccctcctgggtag	9	12	10	10	1	2	0	0	0	2	0	4	2	4	2	2	3	2	2	2	3	4	4	rs150544491		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:219222441C>T	uc002vhr.2	+	3	332	c.303C>T	c.(301-303)TGC>TGT	p.C101C	C2orf62_uc002vhs.2_RNA	NM_198559	NP_940961	Q7Z7H3	CB062_HUMAN	hypothetical protein LOC375307	101											0		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAATGCTCTGCGGAAATTCCC	0.527													22	69					0	0	0	0	T	219222441	T	T	219222441	2	4	8	1	0	0	0	0	0	0	0	1	2191	776	27	1		1	C2orf62	2	219222441	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	16596552	219222441	23976932	106	1995											
CHPF	79586	broad.mit.edu	37	chr2	220405145	220405145	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggcggttcagctcctctaGagctgtccccagaacatcgg	7	8	12	14	3	2	2	1	0	1	2	5	2	4	2	3	3	3	3	3	3	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:220405145G>C	uc002vmc.3	-	4	1515	c.1288C>G	c.(1288-1290)CTA>GTA	p.L430V	CHPF_uc010zlh.1_Missense_Mutation_p.L268V	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	430	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		AGCTCCTCTAGAGCTGTCCCC	0.647													20	18					0	0	0	0	C	220405145	C	C	220405145	3	2	8	1	0	0	0	0	1	0	0	0	3383	933	33	2	1043	2	CHPF	2	220405145	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1182704	220405145	22794228	107	1996											
PTMA	5757	broad.mit.edu	37	chr2	232576621	232576621	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgaggaaaatggggagcagGaggctgacaatgaggtagac	15	5	17	4	0	0	4	0	3	0	1	0	7	0	7	0	6	1	3	0	6	4	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:232576621G>T	uc002vsc.3	+	3	324	c.142G>T	c.(142-144)GAG>TAG	p.E48*	PTMA_uc002vsb.3_Nonsense_Mutation_p.E47*|PTMA_uc010zmf.1_RNA|MIR1244_hsa-mir-1244-1|MI0006379_5'Flank	NM_001099285	NP_001092755	P06454	PTMA_HUMAN	prothymosin, alpha isoform 1	48	Asp/Glu-rich (acidic).				transcription, DNA-dependent	nucleus					0		Renal(207;0.0112)|all_hematologic(139;0.0315)|Acute lymphoblastic leukemia(138;0.0921)|all_lung(227;0.142)		Epithelial(121;1.75e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00221)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		TGGGGAGCAGGAGGCTGACAA	0.418													6	9					3.59834e-05	3.68118e-05	1	0	T	232576621	T	T	232576621	4	4	8	1	0	0	0	0	0	1	0	0	12829	1175	41	2	152	2	PTMA	2	232576621	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	12171476	232576621	10622752	108	1997											
ITPR1	3708	broad.mit.edu	37	chr3	4699900	4699900	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtgcctgaaggcaatgaCatctcctccattttcgagct	8	13	8	12	1	2	2	0	2	2	0	5	3	3	2	3	1	2	2	3	1	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:4699900C>G	uc003bqa.2	+	13	1437	c.1089C>G	c.(1087-1089)GAC>GAG	p.D363E	ITPR1_uc010hca.1_Missense_Mutation_p.D348E|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.D348E	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	363	Cytoplasmic (Potential).|MIR 4.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AAGGCAATGACATCTCCTCCA	0.507													18	64					0	0	0	0	G	4699900	G	G	4699900	3	3	8	1	0	0	0	0	1	0	0	0	7959	477	17	4	1131	4	ITPR1	3	4699900	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		4699900	193322530	109	1998											
ITPR1	3708	broad.mit.edu	37	chr3	4725457	4725457	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gactatggatggtgcatctgGagaaaatgaacataagaaaa	18	8	11	4	0	1	3	0	1	1	2	1	6	1	4	0	3	2	1	0	3	7	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:4725457G>C	uc003bqa.2	+	28	3794	c.3446G>C	c.(3445-3447)GGA>GCA	p.G1149A	ITPR1_uc010hca.1_Missense_Mutation_p.G1134A|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.G80A	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	1158	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GGTGCATCTGGAGAAAATGAA	0.473													19	44					0	0	0	0	C	4725457	C	C	4725457	3	2	8	1	0	0	0	0	1	0	0	0	7959	1174	41	2	3575	2	ITPR1	3	4725457	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	25557	4725457	193296973	110	1999											
PRRT3	285368	broad.mit.edu	37	chr3	9990498	9990498	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacagctgggccagggtctGagggaccagggatgagagac	10	6	17	8	0	1	3	0	2	1	1	1	6	1	5	2	4	2	1	2	4	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:9990498G>C	uc003bul.2	-	3	1245	c.1115C>G	c.(1114-1116)TCA>TGA	p.S372*	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA|PRRT3_uc003bum.2_Nonsense_Mutation_p.S372*	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	372	Extracellular (Potential).|Pro-rich.					integral to membrane					0						GCCAGGGTCTGAGGGACCAGG	0.642													63	168					0	0	0	0	C	9990498	C	C	9990498	4	2	8	1	0	0	0	0	0	1	0	0	12673	1294	45	2	1838	2	PRRT3	3	9990498	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5265041	9990498	188031932	111	2000											
VHL	7428	broad.mit.edu	37	chr3	10188211	10188211	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgataggtcacctttggctCttcagagatgcagggacaca	10	9	11	11	1	3	1	2	0	1	1	3	4	3	2	2	3	1	2	2	3	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:10188211C>T	uc003bvc.2	+	2	567	c.354C>T	c.(352-354)CTC>CTT	p.L118L	VHL_uc003bvd.2_Intron	NM_000551	NP_000542	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor isoform 1	118	Involved in binding to CCT complex.		L -> R (in VHLD).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.L118P(4)|p.W117fs*40(1)|p.L118fs*14(1)|p.L118H(1)|p.?(1)		kidney(1273)|soft_tissue(24)|adrenal_gland(15)|large_intestine(13)|pancreas(5)|endometrium(4)|thyroid(3)|upper_aerodigestive_tract(3)|central_nervous_system(2)|lung(2)|pleura(1)|paratesticular_tissues(1)	1346				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		ACCTTTGGCTCTTCAGAGATG	0.353		1	D|Mis|N|F|S		renal|hemangioma|pheochromocytoma	renal|hemangioma|pheochromocytoma			von_Hippel-Lindau_disease|Chuvash_Polycythemia_|Pheochromocytoma_(Adrenal)_Familial				58	146					0	0	0	0	T	10188211	T	T	10188211	2	4	8	1	0	0	0	0	0	0	0	1	17230	900	32	2		2	VHL	3	10188211	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	197713	10188211	187834219	112	2001											
ATP2B2	491	broad.mit.edu	37	chr3	10392202	10392202	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagccgtgttgatattgtcGccagtgaccatgcggaccgt	7	10	13	11	5	0	2	0	2	0	0	1	4	0	3	4	1	2	1	4	1	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:10392202G>A	uc003bvt.2	-	15	2635	c.2196C>T	c.(2194-2196)GGC>GGT	p.G732G	ATP2B2_uc003bvv.2_Silent_p.G687G|ATP2B2_uc003bvw.2_Silent_p.G687G|ATP2B2_uc010hdo.2_Silent_p.G437G	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	732	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TGATATTGTCGCCAGTGACCA	0.632													26	72					0	0	0	0	A	10392202	A	A	10392202	2	1	8	1	0	0	0	0	0	0	0	1	1142	1074	38	1		1	ATP2B2	3	10392202	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	203991	10392202	187630228	113	2002											
IQSEC1	9922	broad.mit.edu	37	chr3	12983123	12983123	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctctcggagagtgagcgtGagcgcttgatggcctcctcc	6	9	14	12	3	1	4	0	3	1	1	4	5	3	4	3	2	3	2	3	2	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:12983123G>C	uc003bxt.2	-	2	317	c.308C>G	c.(307-309)TCA>TGA	p.S103*	IQSEC1_uc003bxu.3_5'UTR|IQSEC1_uc011auw.1_Nonsense_Mutation_p.S89*	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	103					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						GAGTGAGCGTGAGCGCTTGAT	0.662													5	22					0	0	0	0	C	12983123	C	C	12983123	4	2	8	1	0	0	0	0	0	1	0	0	7856	1294	45	2	3180	2	IQSEC1	3	12983123	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2590921	12983123	185039307	114	2003											
C3orf20	84077	broad.mit.edu	37	chr3	14769987	14769987	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaccaaaaaggaggaggaaGaatttgttcggttcaagatg	15	8	12	6	1	1	2	1	0	0	2	2	5	1	5	2	4	0	2	2	4	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:14769987G>A	uc003byy.2	+	12	2136	c.1732G>A	c.(1732-1734)GAA>AAA	p.E578K	C3orf20_uc003byz.2_Missense_Mutation_p.E456K|C3orf20_uc003bza.2_Missense_Mutation_p.E456K|C3orf20_uc003bzb.1_Missense_Mutation_p.E79K	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	578	Poly-Glu.					cytoplasm|integral to membrane				ovary(3)|skin(1)	4						GGAGGAGGAAGAATTTGTTCG	0.473													23	94					0	0	0	0	A	14769987	A	A	14769987	3	1	8	1	0	0	0	0	1	0	0	0	2223	943	33	2	1770	2	C3orf20	3	14769987	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1786864	14769987	183252443	115	2004											
COLQ	8292	broad.mit.edu	37	chr3	15512102	15512102	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtcctgctatcccaggttCaccttttggacccatttcac	6	14	7	14	0	2	0	2	0	0	0	4	1	4	1	4	2	1	2	4	2	1	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:15512102C>T	uc003bzx.2	-	11	784	c.658G>A	c.(658-660)GAA>AAA	p.E220K	COLQ_uc003bzv.2_Missense_Mutation_p.E210K|COLQ_uc003bzz.2_Missense_Mutation_p.E211K|COLQ_uc010heo.2_Missense_Mutation_p.E186K|COLQ_uc003cac.1_RNA|COLQ_uc003cae.1_Missense_Mutation_p.E79K|COLQ_uc003cad.1_RNA	NM_005677	NP_005668	Q9Y215	COLQ_HUMAN	acetylcholinesterase collagen-like tail subunit	220	Collagen-like 1.				acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft					0						ATCCCAGGTTCACCTTTTGGA	0.537													63	194					0	0	0	0	T	15512102	T	T	15512102	3	4	8	1	0	0	0	0	1	0	0	0	3728	835	29	2	737	2	COLQ	3	15512102	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	742115	15512102	182510328	116	2005											
BTD	686	broad.mit.edu	37	chr3	15686312	15686312	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagtggcatacacacccctCtggagtccttttggtaccat	9	11	9	12	0	1	0	0	0	1	0	2	2	2	1	4	3	2	2	4	3	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:15686312C>T	uc003cah.2	+	4	1052	c.949C>T	c.(949-951)CTG>TTG	p.L317L	BTD_uc011avv.1_Silent_p.L319L|BTD_uc011avw.1_Silent_p.L319L|BTD_uc011avx.1_Silent_p.L297L	NM_000060	NP_000051	P43251	BTD_HUMAN	biotinidase precursor	317	CN hydrolase.				central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity				0						ACACACCCCTCTGGAGTCCTT	0.488													27	89					0	0	0	0	T	15686312	T	T	15686312	2	4	8	1	0	0	0	0	0	0	0	1	1555	912	32	2		2	BTD	3	15686312	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	174210	15686312	182336118	117	2006											
CRTAP	10491	broad.mit.edu	37	chr3	33155701	33155701	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgggacgagctgatgccgctCgagtcggcctaccggcacgc	6	5	15	15	7	0	1	0	1	0	0	2	4	0	2	3	3	3	3	3	3	1	1	rs114946269	by1000genomes	TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:33155701C>T	uc003cfl.3	+	1	252	c.132C>T	c.(130-132)CTC>CTT	p.L44L	CRTAP_uc010hfz.2_Silent_p.L44L|CRTAP_uc003cfm.2_5'UTR|CRTAP_uc003cfn.2_5'UTR	NM_006371	NP_006362	O75718	CRTAP_HUMAN	cartilage associated protein precursor	44						proteinaceous extracellular matrix	binding				0						TGATGCCGCTCGAGTCGGCCT	0.697													6	22					0	0	0	0	T	33155701	T	T	33155701	2	4	8	1	0	0	0	0	0	0	0	1	3913	871	31	1		1	CRTAP	3	33155701	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	17469389	33155701	164866729	118	2007											
ARPP21	10777	broad.mit.edu	37	chr3	35778790	35778790	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccaccacagcagcagccctCcccgcagccccaacagcagg	10	1	9	21	1	0	0	0	0	0	0	1	0	1	0	7	1	6	4	7	1	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:35778790C>A	uc003cgb.2	+	16	1844	c.1580C>A	c.(1579-1581)TCC>TAC	p.S527Y	ARPP21_uc003cga.2_Missense_Mutation_p.S473Y|ARPP21_uc011axy.1_Missense_Mutation_p.S493Y|ARPP21_uc003cgf.2_Missense_Mutation_p.S328Y|ARPP21_uc003cgg.2_Missense_Mutation_p.S15Y	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	527	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CAGCAGCCCTCCCCGCAGCCC	0.642													21	41					5.45024e-15	5.80978e-15	1	0	A	35778790	A	A	35778790	3	1	8	1	0	0	0	0	1	0	0	0	980	855	30	2	1647	2	ARPP21	3	35778790	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2623089	35778790	162243640	119	2008											
OXSR1	9943	broad.mit.edu	37	chr3	38266073	38266073	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttgcaggttttaatgctGacactgcagaacgatcctcc	9	13	8	11	1	1	2	0	1	1	1	3	3	3	2	2	1	4	4	2	1	2	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:38266073G>A	uc003chy.2	+	8	1056	c.714G>A	c.(712-714)CTG>CTA	p.L238L	OXSR1_uc010hhb.2_Silent_p.L172L|OXSR1_uc010hha.1_Silent_p.L170L	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	238	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TTTTAATGCTGACACTGCAGA	0.289													6	80					0	0	0	0	A	38266073	A	A	38266073	2	1	8	1	0	0	0	0	0	0	0	1	11390	1277	45	2		2	OXSR1	3	38266073	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2487283	38266073	159756357	120	2009											
XIRP1	165904	broad.mit.edu	37	chr3	39226071	39226071	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctgatcttgacttgactCtgggcctcagtgtggcattc	5	16	10	10	0	4	3	1	3	3	0	5	3	4	3	1	2	0	1	1	2	0	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:39226071C>G	uc003cjk.1	-	2	5087	c.4866G>C	c.(4864-4866)CAG>CAC	p.Q1622H	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_Missense_Mutation_p.Q305H	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1622							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGACTTGACTCTGGGCCTCAG	0.562													54	161					0	0	0	0	G	39226071	G	G	39226071	3	3	8	1	0	0	0	0	1	0	0	0	17497	912	32	2	669	2	XIRP1	3	39226071	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	959998	39226071	158796359	121	2010											
ZNF167	55888	broad.mit.edu	37	chr3	44612228	44612228	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaatctcattgaccatcaGagaatccacactggggagaa	16	7	9	9	0	2	4	2	1	1	3	4	6	3	4	2	2	0	0	2	2	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:44612228G>C	uc010hin.2	+	6	2014	c.1626G>C	c.(1624-1626)CAG>CAC	p.Q542H	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.Q542H|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	542	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		TTGACCATCAGAGAATCCACA	0.463													48	123					0	0	0	0	C	44612228	C	C	44612228	3	2	8	1	0	0	0	0	1	0	0	0	17808	933	33	2	1644	2	ZNF167	3	44612228	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5386157	44612228	153410202	122	2011											
COL7A1	1294	broad.mit.edu	37	chr3	48625737	48625737	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcaggttgccagtgcagaagGaagccctgcgctctgggcac	8	7	14	12	1	2	1	1	0	1	1	2	2	2	2	2	3	4	4	2	3	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:48625737G>A	uc003ctz.2	-	20	2689	c.2688C>T	c.(2686-2688)TTC>TTT	p.F896F		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	896	Fibronectin type-III 8.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGTGCAGAAGGAAGCCCTGCG	0.682													17	42					0	0	0	0	A	48625737	A	A	48625737	2	1	8	1	0	0	0	0	0	0	0	1	3719	1165	41	2		2	COL7A1	3	48625737	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4013509	48625737	149396693	123	2012											
COL7A1	1294	broad.mit.edu	37	chr3	48626388	48626388	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaacgtcgctggaagcattGaggatctgcagcctcgacac	11	7	12	11	3	1	2	0	1	1	1	3	5	1	4	1	2	4	3	1	2	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:48626388G>A	uc003ctz.2	-	18	2356	c.2355C>T	c.(2353-2355)CTC>CTT	p.L785L		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	785	Nonhelical region (NC1).|Fibronectin type-III 7.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGAAGCATTGAGGATCTGCA	0.607													30	92					0	0	0	0	A	48626388	A	A	48626388	2	1	8	1	0	0	0	0	0	0	0	1	3719	1277	45	2		2	COL7A1	3	48626388	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	651	48626388	149396042	124	2013											
BSN	8927	broad.mit.edu	37	chr3	49692476	49692476	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgcccagagcattggcctCaagccaggcccagtgccaga	10	4	11	16	1	1	2	1	0	0	2	1	2	1	2	6	2	3	1	6	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:49692476C>G	uc003cxe.3	+	5	5601	c.5487C>G	c.(5485-5487)CTC>CTG	p.L1829L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1829					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCATTGGCCTCAAGCCAGGCC	0.612													6	96					0	0	0	0	G	49692476	G	G	49692476	2	3	8	1	0	0	0	0	0	0	0	1	1535	813	29	2		2	BSN	3	49692476	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1066088	49692476	148329954	125	2014											
MST1R	4486	broad.mit.edu	37	chr3	49936568	49936568	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgacgttgtcaaggcgtgtCacatacaatgcagtgacctg	10	10	12	9	2	2	2	2	2	0	0	2	2	2	2	1	1	2	2	1	1	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:49936568C>T	uc003cxy.3	-	2	1623	c.1359G>A	c.(1357-1359)GTG>GTA	p.V453V	MST1R_uc011bdd.1_Silent_p.V453V|MST1R_uc011bde.1_Silent_p.V453V|MST1R_uc011bdf.1_Intron|MST1R_uc011bdg.1_Silent_p.V453V|MST1R_uc011bdc.1_5'Flank	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	453	Extracellular (Potential).|Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CAAGGCGTGTCACATACAATG	0.577													43	97					0	0	0	0	T	49936568	T	T	49936568	2	4	8	1	0	0	0	0	0	0	0	1	9944	813	29	2		2	MST1R	3	49936568	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	244092	49936568	148085862	126	2015											
NT5DC2	64943	broad.mit.edu	37	chr3	52559068	52559068	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatgatgcggatctcacgctCcagctcggggatgatggcgc	7	8	15	11	4	1	2	1	2	1	0	4	5	2	4	1	4	2	2	1	4	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:52559068C>G	uc003deo.2	-	12	1571	c.1147G>C	c.(1147-1149)GAG>CAG	p.E383Q	NT5DC2_uc003dem.2_Missense_Mutation_p.E253Q|NT5DC2_uc003den.2_Missense_Mutation_p.E420Q|NT5DC2_uc010hmi.2_Missense_Mutation_p.E395Q|NT5DC2_uc010hmj.2_Missense_Mutation_p.E199Q	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	383							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		ATCTCACGCTCCAGCTCGGGG	0.682													3	14					0	0	0	0	G	52559068	G	G	52559068	3	3	8	1	0	0	0	0	1	0	0	0	10745	864	30	2	427	2	NT5DC2	3	52559068	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2622500	52559068	145463362	127	2016											
ERC2	26059	broad.mit.edu	37	chr3	55717821	55717821	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atataaaagatggtttctcaCccctcaaaacaaaactggaa	18	9	5	9	0	2	1	2	0	1	1	3	2	2	2	2	2	2	1	2	2	8	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:55717821C>G	uc003dhr.1	-	17	3169	c.2913_splice	c.e17+1		ERC2_uc003dhq.1_Splice_Site	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110							cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TGGTTTCTCACCCCTCAAAAC	0.478													4	63					0	0	0	0	G	55717821	G	G	55717821	5	3	8	1	0	0	0	0	0	0	1	0	5235	521	18	4		4	ERC2	3	55717821	Splice_Site	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3158753	55717821	142304609	128	2017											
ATXN7	6314	broad.mit.edu	37	chr3	63973786	63973786	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggtagaagaaaacgatttGatgtgttattagccgagcac	14	10	12	5	2	0	3	0	1	0	2	0	5	0	3	1	1	3	3	1	1	6	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:63973786G>C	uc003dlw.3	+	9	1700	c.1147G>C	c.(1147-1149)GAT>CAT	p.D383H	ATXN7_uc003dlv.2_Missense_Mutation_p.D383H|ATXN7_uc010hnv.2_Missense_Mutation_p.D383H|ATXN7_uc011bfn.1_Missense_Mutation_p.D238H	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	383	SCA7.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		AAAACGATTTGATGTGTTATT	0.458													74	201					0	0	0	0	C	63973786	C	C	63973786	3	2	8	1	0	0	0	0	1	0	0	0	1217	1290	45	2	1241	2	ATXN7	3	63973786	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8255965	63973786	134048644	129	2018											
MITF	4286	broad.mit.edu	37	chr3	70014321	70014321	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcactgatccactcctttcCtcagtgtcccccggagcttc	5	12	7	17	1	2	1	2	1	0	0	7	2	6	2	5	1	1	1	5	1	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:70014321C>T	uc003dnz.2	+	10	1601	c.1485C>T	c.(1483-1485)TCC>TCT	p.S495S	MITF_uc011bgb.1_Silent_p.S443S|MITF_uc003doa.2_Silent_p.S494S|MITF_uc003dob.2_Silent_p.S479S|MITF_uc003dod.2_Silent_p.S470S|MITF_uc003doe.2_Silent_p.S388S|MITF_uc003dof.2_Silent_p.S394S	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	501					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		CACTCCTTTCCTCAGTGTCCC	0.532			A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						20	74					0	0	0	0	T	70014321	T	T	70014321	2	4	8	1	0	0	0	0	0	0	0	1	9649	668	24	4		4	MITF	3	70014321	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	6040535	70014321	128008109	130	2019											
ROBO2	6092	broad.mit.edu	37	chr3	77666728	77666728	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttacaccaaggtctggaaGatgaactggaagaagatgat	16	8	11	6	0	1	5	0	2	1	3	1	7	1	7	1	3	2	0	1	3	6	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:77666728G>C	uc003dpy.3	+	22	4001	c.3358G>C	c.(3358-3360)GAT>CAT	p.D1120H	ROBO2_uc003dpz.2_Missense_Mutation_p.D1124H|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.D1124H|ROBO2_uc003dqa.2_Missense_Mutation_p.D247H	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1120	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AGGTCTGGAAGATGAACTGGA	0.458													31	84					0	0	0	0	C	77666728	C	C	77666728	3	2	8	1	0	0	0	0	1	0	0	0	13579	942	33	2	3446	2	ROBO2	3	77666728	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	7652407	77666728	120355702	131	2020											
GABRR3	200959	broad.mit.edu	37	chr3	97711819	97711819	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtacacatccacagccttGaggtaggacacctggggcat	11	7	12	11	0	0	1	0	1	0	0	1	2	1	2	3	5	2	3	3	5	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:97711819G>C	uc011bgr.1	-	8	981	c.981C>G	c.(979-981)CTC>CTG	p.L327L		NM_001105580	NP_001099050	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 3	327	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0						CCACAGCCTTGAGGTAGGACA	0.532													16	132					0	0	0	0	C	97711819	C	C	97711819	2	2	8	1	0	0	0	0	0	0	0	1	6212	1277	45	2		2	GABRR3	3	97711819	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	20045091	97711819	100310611	132	2021											
ST3GAL6	10402	broad.mit.edu	37	chr3	98512551	98512551	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgtgactgcagagcagctCtttttgaaggacattataga	13	12	10	6	0	1	4	0	2	1	2	1	5	1	5	0	1	3	3	0	1	4	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:98512551C>G	uc003dsz.2	+	10	1178	c.942C>G	c.(940-942)CTC>CTG	p.L314L	ST3GAL6_uc003dsy.2_Silent_p.L228L|ST3GAL6_uc003dta.2_Silent_p.L196L|ST3GAL6_uc003dtb.2_Silent_p.L170L|ST3GAL6_uc003dtc.2_Silent_p.L314L|ST3GAL6_uc010hpd.2_Silent_p.L367L	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	314	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						CAGAGCAGCTCTTTTTGAAGG	0.353													36	107					0	0	0	0	G	98512551	G	G	98512551	2	3	8	1	0	0	0	0	0	0	0	1	15285	900	32	2		2	ST3GAL6	3	98512551	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	800732	98512551	99509879	133	2022											
ZNF80	7634	broad.mit.edu	37	chr3	113955429	113955429	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaaaaggtttttccacattCtttgcacccaaagagttttt	11	16	6	8	0	1	1	0	0	1	1	2	1	2	1	2	1	1	4	2	1	3	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:113955429C>G	uc010hqo.2	-	1	997	c.493G>C	c.(493-495)GAA>CAA	p.E165Q	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	165	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				TTTCCACATTCTTTGCACCCA	0.488													17	156					0	0	0	0	G	113955429	G	G	113955429	3	3	8	1	0	0	0	0	1	0	0	0	18235	922	32	2	332	2	ZNF80	3	113955429	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	15442878	113955429	84067001	134	2023											
PODXL2	50512	broad.mit.edu	37	chr3	127390296	127390296	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gattggcatccagaactattCcacaaccagcagctgccagg	12	7	9	13	0	0	1	0	0	0	1	2	2	2	1	4	2	5	3	4	2	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:127390296C>G	uc003ejq.2	+	7	1469	c.1445C>G	c.(1444-1446)TCC>TGC	p.S482C	ABTB1_uc003ejr.2_5'Flank|ABTB1_uc003ejs.2_5'Flank|ABTB1_uc003ejt.2_5'Flank|ABTB1_uc003eju.2_5'Flank	NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	482	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						CAGAACTATTCCACAACCAGC	0.632													23	88					0	0	0	0	G	127390296	G	G	127390296	3	3	8	1	0	0	0	0	1	0	0	0	12236	855	30	2	1471	2	PODXL2	3	127390296	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	13434867	127390296	70632134	135	2024											
COL6A6	131873	broad.mit.edu	37	chr3	130300643	130300643	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctacagtgaaaacatactGaatagcttgaaggatataac	18	10	7	6	0	1	3	0	3	1	0	1	4	1	4	0	1	5	1	0	1	9	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:130300643G>C	uc010htl.2	+	8	3817	c.3786G>C	c.(3784-3786)CTG>CTC	p.L1262L	COL6A6_uc003eni.3_5'Flank	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1262	VWFA 7.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AAAACATACTGAATAGCTTGA	0.413													61	164					0	0	0	0	C	130300643	C	C	130300643	2	2	8	1	0	0	0	0	0	0	0	1	3718	1277	45	2		2	COL6A6	3	130300643	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2910347	130300643	67721787	136	2025											
TF	7018	broad.mit.edu	37	chr3	133496034	133496034	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catatgaaaaatacttaggaGaagaatatgtcaaggctgtt	17	11	9	4	0	1	3	1	1	0	2	1	4	1	3	0	2	1	2	0	2	9	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:133496034G>A	uc003epu.1	+	21	3742	c.2014G>A	c.(2014-2016)GAA>AAA	p.E672K	TF_uc011blt.1_Missense_Mutation_p.E545K|TF_uc003epw.1_Missense_Mutation_p.E111K|TF_uc003epv.1_Missense_Mutation_p.E672K	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	672	Transferrin-like 2.			E -> Q (in Ref. 12; AA sequence).	cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	ATACTTAGGAGAAGAATATGT	0.443													13	40					0	0	0	0	A	133496034	A	A	133496034	3	1	8	1	0	0	0	0	1	0	0	0	15851	943	33	2	2076	2	TF	3	133496034	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3195391	133496034	64526396	137	2026											
NCK1	4690	broad.mit.edu	37	chr3	136664663	136664663	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aatggacaagttggatggttCccttcaaactatgtaactga	13	12	9	7	0	1	1	1	1	0	0	2	3	2	3	1	3	2	3	1	3	5	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:136664663C>A	uc003erh.2	+	3	572	c.465C>A	c.(463-465)TTC>TTA	p.F155L	NCK1_uc011bme.1_Missense_Mutation_p.F91L	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	155	SH3 2.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1						TTGGATGGTTCCCTTCAAACT	0.443													19	169					1.15919e-05	1.19447e-05	1	0	A	136664663	A	A	136664663	3	1	8	1	0	0	0	0	1	0	0	0	10273	854	30	2	471	2	NCK1	3	136664663	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3168629	136664663	61357767	138	2027											
C3orf58	205428	broad.mit.edu	37	chr3	143691432	143691432	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcgcctgctggacttcctCaacgtgaagaacgtgtactt	8	12	10	11	3	1	2	1	1	0	1	2	3	2	3	2	1	5	2	2	1	4	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:143691432C>G	uc003evo.2	+	1	793	c.258C>G	c.(256-258)CTC>CTG	p.L86L	C3orf58_uc011bnl.1_5'Flank	NM_173552	NP_775823	Q8NDZ4	CC058_HUMAN	hypothetical protein LOC205428 isoform a	86						COPI vesicle coat|extracellular region				ovary(1)	1						TGGACTTCCTCAACGTGAAGA	0.697													7	48					0	0	0	0	G	143691432	G	G	143691432	2	3	8	1	0	0	0	0	0	0	0	1	2246	813	29	2		2	C3orf58	3	143691432	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7026769	143691432	54330998	139	2028											
PLOD2	5352	broad.mit.edu	37	chr3	145828128	145828128	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggatacttgtctgctagtCttttatctggccacaaaatt	10	15	7	9	0	3	0	0	0	3	0	3	1	3	1	1	2	2	1	1	2	5	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:145828128C>G	uc003evs.1	-	4	952	c.446G>C	c.(445-447)AGA>ACA	p.R149T	PLOD2_uc011bnm.1_Missense_Mutation_p.R94T|PLOD2_uc003evr.1_Missense_Mutation_p.R149T	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	149					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	GTCTGCTAGTCTTTTATCTGG	0.388													25	76					0	0	0	0	G	145828128	G	G	145828128	3	3	8	1	0	0	0	0	1	0	0	0	12157	913	32	2	1898	2	PLOD2	3	145828128	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2136696	145828128	52194302	140	2029											
IGSF10	285313	broad.mit.edu	37	chr3	151155923	151155923	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttttgttactctgccttatCcggggagcagctgttataac	7	15	10	9	1	1	0	0	0	1	0	2	1	2	1	2	2	5	5	2	2	4	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:151155923C>T	uc011bod.1	-	6	6426	c.6426G>A	c.(6424-6426)CGG>CGA	p.R2142R	IGSF10_uc011bob.1_Silent_p.R169R|IGSF10_uc011boc.1_Silent_p.R121R	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2142	Ig-like C2-type 8.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTGCCTTATCCGGGGAGCAG	0.458													25	62					0	0	0	0	T	151155923	T	T	151155923	2	4	8	1	0	0	0	0	0	0	0	1	7636	842	30	2		2	IGSF10	3	151155923	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5327795	151155923	46866507	141	2030											
USP13	8975	broad.mit.edu	37	chr3	179481862	179481862	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcctctgtttttggtgcttCtggactggataaccaacctc	7	14	9	11	0	2	0	0	0	2	0	3	2	2	2	3	3	4	2	3	3	2	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:179481862C>G	uc003fkh.2	+	18	2246	c.2165C>G	c.(2164-2166)TCT>TGT	p.S722C		NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	722					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TTTGGTGCTTCTGGACTGGAT	0.502													31	98					0	0	0	0	G	179481862	G	G	179481862	3	3	8	1	0	0	0	0	1	0	0	0	17112	913	32	2	2235	2	USP13	3	179481862	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	28325939	179481862	18540568	142	2031											
TP63	8626	broad.mit.edu	37	chr3	189582183	189582183	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagcggtgccccaaccatGagctgagccgtgaattcaac	11	7	11	12	2	1	4	1	4	0	0	1	4	1	4	4	1	6	1	4	1	4	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:189582183G>A	uc003fry.2	+	5	831	c.742G>A	c.(742-744)GAG>AAG	p.E248K	TP63_uc003frx.2_Missense_Mutation_p.E248K|TP63_uc003frz.2_Missense_Mutation_p.E248K|TP63_uc010hzc.1_Missense_Mutation_p.E248K|TP63_uc003fsa.2_Missense_Mutation_p.E154K|TP63_uc003fsb.2_Missense_Mutation_p.E154K|TP63_uc003fsc.2_Missense_Mutation_p.E154K|TP63_uc003fsd.2_Missense_Mutation_p.E154K|TP63_uc010hzd.1_Missense_Mutation_p.E69K|TP63_uc003fse.1_Missense_Mutation_p.E129K	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	248					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CCCCAACCATGAGCTGAGCCG	0.517									Hay-Wells_syndrome	HNSCC(45;0.13)			25	64					0	0	0	0	A	189582183	A	A	189582183	3	1	8	1	0	0	0	0	1	0	0	0	16459	1291	45	2	806	2	TP63	3	189582183	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	10100321	189582183	8440247	143	2032											
TP63	8626	broad.mit.edu	37	chr3	189586432	189586432	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcttgcccaggaagagacagGaaggcggatgaagatagcat	14	5	15	7	1	0	3	0	1	0	2	0	7	0	6	1	4	2	2	1	4	4	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:189586432G>A	uc003fry.2	+	8	1145	c.1056G>A	c.(1054-1056)AGG>AGA	p.R352R	TP63_uc003frx.2_Silent_p.R352R|TP63_uc003frz.2_Silent_p.R352R|TP63_uc010hzc.1_Silent_p.R352R|TP63_uc003fsa.2_Silent_p.R258R|TP63_uc003fsb.2_Silent_p.R258R|TP63_uc003fsc.2_Silent_p.R258R|TP63_uc003fsd.2_Silent_p.R258R|TP63_uc010hzd.1_Silent_p.R173R|TP63_uc003fse.1_Silent_p.R233R	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	352	|Interaction with HIPK2.		R -> G (in EDRH and OFC8).		anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GAAGAGACAGGAAGGCGGATG	0.502									Hay-Wells_syndrome	HNSCC(45;0.13)			17	66					0	0	0	0	A	189586432	A	A	189586432	2	1	8	1	0	0	0	0	0	0	0	1	16459	1165	41	2		2	TP63	3	189586432	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4249	189586432	8435998	144	2033											
PIGZ	80235	broad.mit.edu	37	chr3	196674441	196674441	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aggggcatggaccacctgctCcaggtactccaggccaggca	9	5	13	14	0	0	0	0	0	0	0	2	1	2	1	5	6	2	4	5	6	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:196674441C>G	uc003fxh.2	-	3	1474	c.1327G>C	c.(1327-1329)GAG>CAG	p.E443Q		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	443					GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			ovary(3)	3	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		ACCACCTGCTCCAGGTACTCC	0.647													4	46					0	0	0	0	G	196674441	G	G	196674441	3	3	8	1	0	0	0	0	1	0	0	0	11960	864	30	2	416	2	PIGZ	3	196674441	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7088009	196674441	1347989	145	2034											
BDH1	622	broad.mit.edu	37	chr3	197259341	197259341	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgcagatgcttggccaatGagaacccaaatccagagtca	15	7	9	10	0	1	3	1	1	0	3	2	4	2	3	3	1	3	2	3	1	4	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:197259341G>A	uc003fxr.2	-	5	611	c.209C>T	c.(208-210)TCA>TTA	p.S70L	BDH1_uc003fxs.2_Missense_Mutation_p.S70L|BDH1_uc003fxt.2_5'UTR|BDH1_uc003fxu.2_Missense_Mutation_p.S70L	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	70	NAD (By similarity).			S -> A (in Ref. 3; AAH11964).	cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	CTTGGCCAATGAGAACCCAAA	0.473													10	42					0	0	0	0	A	197259341	A	A	197259341	3	1	8	1	0	0	0	0	1	0	0	0	1392	1294	45	2	838	2	BDH1	3	197259341	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	584900	197259341	763089	146	2035											
MXD4	10608	broad.mit.edu	37	chr4	2259719	2259719	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtcacttacctgtgcttttCtagctcgttgtgtgaagacc	6	15	10	10	1	2	2	1	1	1	1	3	2	2	2	2	1	3	3	2	1	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:2259719C>G	uc003geu.1	-	3	216	c.184G>C	c.(184-186)GAA>CAA	p.E62Q	MXD4_uc003gev.1_RNA	NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	62	Basic motif.				negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						CTGTGCTTTTCTAGCTCGTTG	0.582													13	47					0	0	0	0	G	2259719	G	G	2259719	3	3	8	1	0	0	0	0	1	0	0	0	10054	922	32	2	461	2	MXD4	4	2259719	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		2259719	188894557	147	2036											
LDB2	9079	broad.mit.edu	37	chr4	16590367	16590367	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttctcgggactaactctCggtattgtctaatggtaaag	9	14	10	8	2	3	0	0	0	3	0	5	1	3	1	0	3	2	3	0	3	5	6	rs142034467		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:16590367C>A	uc003goz.2	-	4	813	c.497G>T	c.(496-498)CGA>CTA	p.R166L	LDB2_uc003gpa.2_Missense_Mutation_p.R166L|LDB2_uc003gpb.2_Missense_Mutation_p.R166L|LDB2_uc011bxh.1_Missense_Mutation_p.R166L|LDB2_uc010iee.2_Missense_Mutation_p.R166L|LDB2_uc003goy.2_Missense_Mutation_p.R42L|LDB2_uc011bxi.1_Missense_Mutation_p.R42L	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	166							LIM domain binding|transcription cofactor activity				0						GACTAACTCTCGGTATTGTCT	0.393													26	71					7.26314e-15	7.73068e-15	1	0	A	16590367	A	A	16590367	3	1	8	1	0	0	0	0	1	0	0	0	8736	884	31	3	753	3	LDB2	4	16590367	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	14330648	16590367	174563909	148	2037											
APBB2	323	broad.mit.edu	37	chr4	41016114	41016114	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccttgctctgcagccttacgGagctggttctccccattttt	4	15	8	14	1	2	0	0	0	2	0	3	1	2	1	4	2	5	4	4	2	1	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:41016114G>A	uc003gvl.2	-	6	951	c.321C>T	c.(319-321)CTC>CTT	p.L107L	APBB2_uc003gvm.2_Silent_p.L107L|APBB2_uc003gvn.2_Silent_p.L107L|APBB2_uc011byt.1_Silent_p.L90L	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	107					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						CAGCCTTACGGAGCTGGTTCT	0.562													23	70					0	0	0	0	A	41016114	A	A	41016114	2	1	8	1	0	0	0	0	0	0	0	1	761	1161	41	2		2	APBB2	4	41016114	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	24425747	41016114	150138162	149	2038											
KCTD8	386617	broad.mit.edu	37	chr4	44176989	44176989	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacttgctgatgagggtctGaaagagttcactgtttctgc	8	13	13	7	0	3	4	1	3	2	1	3	5	3	5	0	2	2	3	0	2	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:44176989G>C	uc003gwu.2	-	2	1524	c.1240C>G	c.(1240-1242)CAG>GAG	p.Q414E		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	414						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						ATGAGGGTCTGAAAGAGTTCA	0.428										HNSCC(17;0.042)			77	247					0	0	0	0	C	44176989	C	C	44176989	3	2	8	1	0	0	0	0	1	0	0	0	8154	1299	45	2	185	2	KCTD8	4	44176989	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3160875	44176989	146977287	150	2039											
LNX1	84708	broad.mit.edu	37	chr4	54364928	54364928	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcccaccagcctaatagaGaggctttcactgggatctac	10	9	8	14	0	2	1	1	0	1	1	3	3	3	2	4	2	2	1	4	2	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:54364928G>C	uc003hag.3	-	5	1114	c.858C>G	c.(856-858)CTC>CTG	p.L286L	PDGFRA_uc003haa.2_Intron|LNX1_uc003haf.3_Silent_p.L190L|LNX1_uc003hah.3_Intron	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a	286	PDZ 1.					cytoplasm	zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			GCCTAATAGAGAGGCTTTCAC	0.483													21	60					0	0	0	0	C	54364928	C	C	54364928	2	2	8	1	0	0	0	0	0	0	0	1	8907	929	33	2		2	LNX1	4	54364928	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	10187939	54364928	136789348	151	2040											
EPHA5	2044	broad.mit.edu	37	chr4	66217204	66217204	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactgttgattaagatgtttCtggcagcaagatctctatgc	10	15	9	7	0	2	3	0	1	2	2	3	3	2	3	0	1	3	4	0	1	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:66217204C>T	uc003hcy.2	-	14	2604	c.2411G>A	c.(2410-2412)AGA>AAA	p.R804K	EPHA5_uc003hcx.2_Missense_Mutation_p.R736K|EPHA5_uc003hcz.2_Missense_Mutation_p.R782K|EPHA5_uc011cah.1_Missense_Mutation_p.R805K|EPHA5_uc011cai.1_Missense_Mutation_p.R783K|EPHA5_uc003hda.2_Missense_Mutation_p.R805K	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	804	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TAAGATGTTTCTGGCAGCAAG	0.473										TSP Lung(17;0.13)			18	65					0	0	0	0	T	66217204	T	T	66217204	3	4	8	1	0	0	0	0	1	0	0	0	5194	913	32	2	722	2	EPHA5	4	66217204	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	11852276	66217204	124937072	152	2041											
UBA6	55236	broad.mit.edu	37	chr4	68514899	68514899	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttgggcagtccaagagaGccaatgcacaatgtcagcat	12	7	11	11	0	1	1	1	0	0	1	2	2	2	1	3	1	3	3	3	1	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:68514899G>A	uc003hdg.3	-	14	1187	c.1135C>T	c.(1135-1137)CTC>TTC	p.L379F	UBA6_uc003hdh.1_5'UTR	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	379					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						GTCCAAGAGAGCCAATGCACA	0.398													12	49					0	0	0	0	A	68514899	A	A	68514899	3	1	8	1	0	0	0	0	1	0	0	0	16900	971	34	4	2103	4	UBA6	4	68514899	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2297695	68514899	122639377	153	2042											
UGT2B15	7366	broad.mit.edu	37	chr4	69535910	69535910	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgacatcaaactttgactCttgtagtttcatcataagtt	13	16	5	7	0	4	2	3	2	1	0	4	2	4	2	0	0	1	3	0	0	4	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:69535910C>T	uc011cal.1	-	1	465	c.427G>A	c.(427-429)GAG>AAG	p.E143K		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	143					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						AACTTTGACTCTTGTAGTTTC	0.363													95	271					0	0	0	0	T	69535910	T	T	69535910	3	4	8	1	0	0	0	0	1	0	0	0	17026	922	32	2	2806	2	UGT2B15	4	69535910	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1021011	69535910	121618366	154	2043											
UGT2A3	79799	broad.mit.edu	37	chr4	69816835	69816835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagaagtggaacaaaactGaaagcattgaattttttact	16	12	7	6	0	0	3	0	2	0	1	1	4	1	4	1	1	4	1	1	1	7	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:69816835G>A	uc003hef.2	-	1	675	c.644C>T	c.(643-645)TCA>TTA	p.S215L	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	215	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GAACAAAACTGAAAGCATTGA	0.358													13	33					0	0	0	0	A	69816835	A	A	69816835	3	1	8	1	0	0	0	0	1	0	0	0	17023	1294	45	2	963	2	UGT2A3	4	69816835	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	280925	69816835	121337441	155	2044											
ADAMTS3	9508	broad.mit.edu	37	chr4	73149386	73149386	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgtgccaacacttccatttGacagaatatggacttgtctc	10	13	7	11	1	1	2	0	1	1	1	4	3	2	3	2	1	2	0	2	1	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:73149386G>A	uc003hgk.1	-	22	3122	c.3085C>T	c.(3085-3087)CAA>TAA	p.Q1029*		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1029	PLAC.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ACTTCCATTTGACAGAATATG	0.393													25	63					0	0	0	0	A	73149386	A	A	73149386	4	1	8	1	0	0	0	0	0	1	0	0	267	1299	45	2	536	2	ADAMTS3	4	73149386	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3332551	73149386	118004890	156	2045											
PARM1	25849	broad.mit.edu	37	chr4	75938051	75938051	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cactcatctcccctcaagctCcagcctcatcaccctcatcc	8	9	2	22	0	6	0	5	0	1	0	9	0	8	0	6	0	2	1	6	0	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:75938051C>G	uc003hih.1	+	2	700	c.460C>G	c.(460-462)CCA>GCA	p.P154A		NM_015393	NP_056208	Q6UWI2	PARM1_HUMAN	prostatic androgen-repressed message-1	154	Extracellular (Potential).				positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				ovary(1)	1						CCCTCAAGCTCCAGCCTCATC	0.587													59	204					0	0	0	0	G	75938051	G	G	75938051	3	3	8	1	0	0	0	0	1	0	0	0	11506	855	30	2	466	2	PARM1	4	75938051	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2788665	75938051	115216225	157	2046											
USO1	8615	broad.mit.edu	37	chr4	76703974	76703974	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgaaaattctggctggtCtgcacagaaagtgaccaatc	14	9	10	8	0	2	4	0	2	2	2	3	4	2	4	1	2	1	2	1	2	4	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:76703974C>G	uc003hiu.2	+	8	993	c.818C>G	c.(817-819)TCT>TGT	p.S273C	USO1_uc003hiv.2_Missense_Mutation_p.S108C|USO1_uc003hiw.2_Missense_Mutation_p.S108C	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	273	ARM 5.|Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCTGGCTGGTCTGCACAGAAA	0.328													5	30					0	0	0	0	G	76703974	G	G	76703974	3	3	8	1	0	0	0	0	1	0	0	0	17107	913	32	2	693	2	USO1	4	76703974	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	765923	76703974	114450302	158	2047											
SEC31A	22872	broad.mit.edu	37	chr4	83791497	83791497	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cctctcctgtgtttggattgGagcagagaatcttagcatct	8	14	10	9	0	3	1	0	0	3	1	4	4	3	3	2	2	2	3	2	2	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:83791497G>C	uc003hnf.2	-	8	1027	c.863C>G	c.(862-864)TCC>TGC	p.S288C	SEC31A_uc003hne.2_Missense_Mutation_p.S60C|SEC31A_uc011ccl.1_Missense_Mutation_p.S288C|SEC31A_uc003hnl.2_Missense_Mutation_p.S288C|SEC31A_uc003hng.2_Missense_Mutation_p.S288C|SEC31A_uc003hnh.2_Missense_Mutation_p.S288C|SEC31A_uc003hni.2_Missense_Mutation_p.S288C|SEC31A_uc003hnj.2_Missense_Mutation_p.S288C|SEC31A_uc011ccm.1_Missense_Mutation_p.S283C|SEC31A_uc011ccn.1_Missense_Mutation_p.S288C|SEC31A_uc003hnk.2_Missense_Mutation_p.S288C|SEC31A_uc003hnm.2_Missense_Mutation_p.S288C|SEC31A_uc003hnn.1_Missense_Mutation_p.S288C|SEC31A_uc003hno.2_Missense_Mutation_p.S288C	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	288	Interaction with SEC13.|WD 5.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				GTTTGGATTGGAGCAGAGAAT	0.408													38	134					0	0	0	0	C	83791497	C	C	83791497	3	2	8	1	0	0	0	0	1	0	0	0	14063	1174	41	2	2879	2	SEC31A	4	83791497	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	7087523	83791497	107362779	159	2048											
MANBA	4126	broad.mit.edu	37	chr4	103585971	103585971	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcattttcattattgccactCcatatgatgatagaaggatg	12	15	7	7	0	2	3	2	2	0	1	3	4	3	4	2	1	1	0	2	1	4	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:103585971C>T	uc003hwg.2	-	11	1456	c.1356G>A	c.(1354-1356)TGG>TGA	p.W452*	MANBA_uc011ces.1_Nonsense_Mutation_p.W395*	NM_005908	NP_005899	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal precursor	452					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		TATTGCCACTCCATATGATGA	0.343													24	73					0	0	0	0	T	103585971	T	T	103585971	4	4	8	1	0	0	0	0	0	1	0	0	9272	856	30	2	1311	2	MANBA	4	103585971	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	19794474	103585971	87568305	160	2049											
COL25A1	84570	broad.mit.edu	37	chr4	109780855	109780856	+	Frame_Shift_Ins	INS	-	TGGC	TGGC																															gttgtagtctatgatctcagINStggctccttgatcccctttt																										TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:109780855_109780856insTGGC	uc003hze.1	-	23	1807_1808	c.1276_1277insGCCA	c.(1276-1278)ACTfs	p.T426fs	COL25A1_uc003hzg.2_Frame_Shift_Ins_p.T426fs|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Frame_Shift_Ins_p.T192fs	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	426	Extracellular (Potential).					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TATGATCTCAGTGGCTCCTTGA	0.51													---	---	---								TGGC	109780856	TGGC	TGGC	109780855	7	5	8	1	0	1	1	0	0	0	0	0	3699	1029	36	0	831	0	COL25A1	4	109780855	Frame_Shift_Ins	INS	-	TCGA-BA-5152-01A-02D-1870-08	6194884	109780855	81373421	161	2050											
ENPEP	2028	broad.mit.edu	37	chr4	111470954	111470954	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcatggaactacactcttGagcaataccagaaaacttca	15	11	5	10	0	3	2	2	1	1	1	3	3	3	3	1	1	5	1	1	1	6	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:111470954G>C	uc003iab.3	+	17	2755	c.2413G>C	c.(2413-2415)GAG>CAG	p.E805Q		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	805	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CTACACTCTTGAGCAATACCA	0.413													22	61					0	0	0	0	C	111470954	C	C	111470954	3	2	8	1	0	0	0	0	1	0	0	0	5152	1291	45	2	2479	2	ENPEP	4	111470954	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1690099	111470954	79683322	162	2051											
C4orf21	55345	broad.mit.edu	37	chr4	113468485	113468485	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtttgttccaatccattttCatgagctgcatcagaaccct	10	14	6	11	0	2	2	2	1	0	1	4	2	4	2	3	0	3	4	3	0	2	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:113468485C>T	uc003iau.2	-	24	5765	c.5554G>A	c.(5554-5556)GAA>AAA	p.E1852K	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Missense_Mutation_p.E310K	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	674						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		AATCCATTTTCATGAGCTGCA	0.363													10	57					0	0	0	0	T	113468485	T	T	113468485	3	4	8	1	0	0	0	0	1	0	0	0	2264	835	29	2	780	2	C4orf21	4	113468485	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1997531	113468485	77685791	163	2052											
SEC24D	9871	broad.mit.edu	37	chr4	119736304	119736304	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcctgccatctggggaccaGagttggctgcttggaaaaaa	10	8	13	10	1	1	1	0	0	1	1	1	3	1	3	3	4	2	3	3	4	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:119736304G>C	uc003ici.3	-	6	952	c.680C>G	c.(679-681)TCT>TGT	p.S227C	SEC24D_uc003icj.3_Missense_Mutation_p.S228C|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA|SEC24D_uc011cgg.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	227	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						CTGGGGACCAGAGTTGGCTGC	0.498													20	64					0	0	0	0	C	119736304	C	C	119736304	3	2	8	1	0	0	0	0	1	0	0	0	14062	942	33	2	2490	2	SEC24D	4	119736304	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	6267819	119736304	71417972	164	2053											
FAT4	79633	broad.mit.edu	37	chr4	126241934	126241934	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacattaatggtcaactatcCtacacaatcattcaacagat	16	11	4	10	0	3	1	3	0	0	1	4	2	4	1	1	1	3	0	1	1	6	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:126241934C>A	uc003ifj.3	+	1	4368	c.4368C>A	c.(4366-4368)TCC>TCA	p.S1456S		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1456	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTCAACTATCCTACACAATCA	0.388													27	101					4.22769e-11	4.44658e-11	1	0	A	126241934	A	A	126241934	2	1	8	1	0	0	0	0	0	0	0	1	5724	668	24	4		4	FAT4	4	126241934	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	6505630	126241934	64912342	165	2054											
TUBB4Q	56604	broad.mit.edu	37	chr4	190903695	190903695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcctcatactcctcctccctCggccgtggcatcctgatatt	5	13	6	17	2	1	1	1	1	0	0	7	1	6	1	6	2	1	1	6	2	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:190903695C>T	uc011clg.1	-	4	1288	c.1285G>A	c.(1285-1287)GAG>AAG	p.E429K		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	430					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		CCTCCTCCCTCGGCCGTGGCA	0.532													84	209					0	0	0	0	T	190903695	T	T	190903695	3	4	8	1	0	0	0	0	1	0	0	0	16827	893	31	1	19	1	TUBB4Q	4	190903695	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	64661761	190903695	250581	166	2055											
PDZD2	23037	broad.mit.edu	37	chr5	32091009	32091009	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgctccaagctccaggagctGagagccttgagcatgcctga	9	7	12	13	1	0	3	0	3	0	1	2	5	2	4	4	1	5	4	4	1	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:32091009G>C	uc003jhl.2	+	20	7843	c.7455G>C	c.(7453-7455)CTG>CTC	p.L2485L	PDZD2_uc003jhm.2_Silent_p.L2485L	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2485					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						TCCAGGAGCTGAGAGCCTTGA	0.607													30	59					0	0	0	0	C	32091009	C	C	32091009	2	2	8	1	0	0	0	0	0	0	0	1	11755	1277	45	2		2	PDZD2	5	32091009	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08		32091009	148824251	167	2056											
SKP2	6502	broad.mit.edu	37	chr5	36181975	36181975	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtttttggaatcgtgccaGatggtacccttcaactgtta	10	14	9	8	1	1	1	1	0	0	1	2	2	1	2	2	2	3	3	2	2	5	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:36181975G>C	uc003jkc.1	+	10	1299	c.1117G>C	c.(1117-1119)GAT>CAT	p.D373H	SKP2_uc011cou.1_Missense_Mutation_p.D159H|SKP2_uc003jkd.2_Intron	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	373					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AATCGTGCCAGATGGTACCCT	0.403													65	159					0	0	0	0	C	36181975	C	C	36181975	3	2	8	1	0	0	0	0	1	0	0	0	14427	942	33	2	1155	2	SKP2	5	36181975	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4090966	36181975	144733285	168	2057											
WDR70	55100	broad.mit.edu	37	chr5	37479940	37479940	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttcttttcgtacagccatCagatcaagtcattacagtat	11	16	5	9	1	4	1	3	0	1	1	5	1	4	1	1	0	3	2	1	0	4	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:37479940C>T	uc003jkv.2	+	8	749	c.691C>T	c.(691-693)CAG>TAG	p.Q231*	WDR70_uc010iva.1_Nonsense_Mutation_p.Q231*	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	231	WD 2.									ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTACAGCCATCAGATCAAGTC	0.338													30	107					0	0	0	0	T	37479940	T	T	37479940	4	4	8	1	0	0	0	0	0	1	0	0	17389	827	29	2	721	2	WDR70	5	37479940	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1297965	37479940	143435320	169	2058											
C5orf51	285636	broad.mit.edu	37	chr5	41911231	41911231	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtatatgtattgtcattctCttaccaaaagaagagagtgg	13	14	9	5	0	2	2	1	0	1	2	3	3	2	2	1	1	1	2	1	1	7	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:41911231C>G	uc003jmo.2	+	4	436	c.436C>G	c.(436-438)CTT>GTT	p.L146V		NM_175921	NP_787117	A6NDU8	CE051_HUMAN	hypothetical protein LOC285636	146											0						TTGTCATTCTCTTACCAAAAG	0.388													16	44					0	0	0	0	G	41911231	G	G	41911231	3	3	8	1	0	0	0	0	1	0	0	0	2318	913	32	2	450	2	C5orf51	5	41911231	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4431291	41911231	139004029	170	2059											
PAIP1	10605	broad.mit.edu	37	chr5	43535702	43535702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttcttccatatccatctttCctttttccttccaagcatct	6	20	1	14	0	3	0	0	0	3	0	8	0	8	0	5	0	1	1	5	0	2	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:43535702C>T	uc003job.2	-	7	1260	c.1013G>A	c.(1012-1014)GGA>GAA	p.G338E	PAIP1_uc003joa.2_Missense_Mutation_p.G259E|PAIP1_uc010ivp.2_Missense_Mutation_p.G259E|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.G226E	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	338	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ATCCATCTTTCCTTTTTCCTT	0.328													15	46					0	0	0	0	T	43535702	T	T	43535702	3	4	8	1	0	0	0	0	1	0	0	0	11450	855	30	2	446	2	PAIP1	5	43535702	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1624471	43535702	137379558	171	2060											
NNT	23530	broad.mit.edu	37	chr5	43616149	43616149	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggatatgatgcgctaagctCcatggccaacattgcggggt	9	9	14	9	2	0	1	0	1	0	0	1	2	1	2	2	4	4	2	2	4	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:43616149C>T	uc003joe.2	+	4	836	c.581C>T	c.(580-582)TCC>TTC	p.S194F	NNT_uc003jof.2_Missense_Mutation_p.S194F	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	194	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	GCGCTAAGCTCCATGGCCAAC	0.433													64	133					0	0	0	0	T	43616149	T	T	43616149	3	4	8	1	0	0	0	0	1	0	0	0	10564	855	30	2	591	2	NNT	5	43616149	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	80447	43616149	137299111	172	2061											
PARP8	79668	broad.mit.edu	37	chr5	50091070	50091070	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcttactctagtaatctcaGaatggaagaattatatggac	14	13	8	6	0	3	2	1	0	3	2	4	4	3	4	0	2	1	1	0	2	8	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:50091070G>C	uc003jon.3	+	13	1429	c.1247G>C	c.(1246-1248)AGA>ACA	p.R416T	PARP8_uc011cpz.1_Missense_Mutation_p.R308T|PARP8_uc003joo.2_Missense_Mutation_p.R416T|PARP8_uc003jop.2_Missense_Mutation_p.R416T	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	416						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				AGTAATCTCAGAATGGAAGAA	0.418													12	76					0	0	0	0	C	50091070	C	C	50091070	3	2	8	1	0	0	0	0	1	0	0	0	11519	942	33	2	1293	2	PARP8	5	50091070	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	6474921	50091070	130824190	173	2062											
MAST4	375449	broad.mit.edu	37	chr5	66456300	66456300	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagagtgggaataaggtgtCaatcactactaccccatttg	12	12	9	8	0	2	1	2	0	0	1	2	2	2	2	2	2	2	0	2	2	6	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:66456300C>G	uc003jut.1	+	26	3166	c.3098C>G	c.(3097-3099)TCA>TGA	p.S1033*	MAST4_uc003juw.2_Nonsense_Mutation_p.S961*	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1225	PDZ.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AATAAGGTGTCAATCACTACT	0.423													64	186					0	0	0	0	G	66456300	G	G	66456300	4	3	8	1	0	0	0	0	0	1	0	0	9380	838	29	2	3901	2	MAST4	5	66456300	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	16365230	66456300	114458960	174	2063											
GCNT4	51301	broad.mit.edu	37	chr5	74324700	74324700	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccataaatacacacgcttCgaaggtgagatccagtacaa	15	8	7	11	2	0	1	0	1	0	1	3	3	2	1	2	1	2	2	2	1	6	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:74324700C>T	uc003kdn.2	-	1	2025	c.1163G>A	c.(1162-1164)CGA>CAA	p.R388Q		NM_016591	NP_057675	Q9P109	GCNT4_HUMAN	core 2 beta-1,6-N-acetylglucosaminyltransferase	388	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		ACACACGCTTCGAAGGTGAGA	0.418													24	64					0	0	0	0	T	74324700	T	T	74324700	3	4	8	1	0	0	0	0	1	0	0	0	6338	884	31	1	202	1	GCNT4	5	74324700	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7868400	74324700	106590560	175	2064											
HMGCR	3156	broad.mit.edu	37	chr5	74646146	74646146	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccattttgcccgagttttaGaagaagaagaaaataagccg	15	9	10	7	2	0	4	0	0	0	4	0	5	0	4	3	0	2	1	3	0	7	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:74646146G>A	uc003kdp.2	+	8	883	c.727G>A	c.(727-729)GAA>AAA	p.E243K	HMGCR_uc011cst.1_Missense_Mutation_p.E263K|HMGCR_uc003kdq.2_Missense_Mutation_p.E243K|HMGCR_uc010izn.1_Intron	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	243					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CCGAGTTTTAGAAGAAGAAGA	0.413													5	65					0	0	0	0	A	74646146	A	A	74646146	3	1	8	1	0	0	0	0	1	0	0	0	7270	943	33	2	753	2	HMGCR	5	74646146	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	321446	74646146	106269114	176	2065											
S100Z	170591	broad.mit.edu	37	chr5	76171314	76171314	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcctgcagcgagagctcacgGaattcctctcggtgagtcag	8	9	12	12	3	3	2	2	1	1	1	6	4	5	3	2	2	3	2	2	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:76171314G>A	uc003kep.1	+	3	460	c.130G>A	c.(130-132)GAA>AAA	p.E44K	S100Z_uc003keq.3_Missense_Mutation_p.E44K	NM_130772	NP_570128	Q8WXG8	S100Z_HUMAN	S100 calcium binding protein Z	44	EF-hand 1.						calcium ion binding			ovary(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;8.91e-51)|Epithelial(54;5.43e-45)|all cancers(79;1.82e-40)		AGAGCTCACGGAATTCCTCTC	0.493													32	111					0	0	0	0	A	76171314	A	A	76171314	3	1	8	1	0	0	0	0	1	0	0	0	13857	1175	41	2	132	2	S100Z	5	76171314	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1525168	76171314	104743946	177	2066											
ATP6AP1L	92270	broad.mit.edu	37	chr5	81613993	81613993	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaccaacaatatgatctcatCgcctctcctgcccacttctc	9	11	4	17	1	3	1	1	1	3	0	7	2	3	1	4	0	2	0	4	0	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:81613993C>T	uc003khv.2	+	10	1874	c.549C>T	c.(547-549)ATC>ATT	p.I183I	ATP6AP1L_uc003khw.2_Silent_p.I183I	NM_001017971	NP_001017971	Q52LC2	VAS1L_HUMAN	ATPase, H+ transporting, lysosomal accessory	183					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0						ATGATCTCATCGCCTCTCCTG	0.557													17	70					0	0	0	0	T	81613993	T	T	81613993	2	4	8	1	0	0	0	0	0	0	0	1	1168	874	31	1		1	ATP6AP1L	5	81613993	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5442679	81613993	99301267	178	2067											
CETN3	1070	broad.mit.edu	37	chr5	89705476	89705476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accgacctcagagctaaactCattatctcttcgcacagaga	13	9	6	13	2	3	2	2	0	1	2	5	4	3	2	2	0	2	2	2	0	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:89705476C>T	uc003kjo.2	-	1	128	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_004365	NP_004356	O15182	CETN3_HUMAN	centrin 3	1					cell division|centrosome cycle|mitosis	centriole	calcium ion binding				0		all_cancers(142;7.93e-09)|all_epithelial(76;2.13e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.42e-32)|Epithelial(54;1.45e-26)|all cancers(79;2.87e-23)		GAGCTAAACTCATTATCTCTT	0.582													38	114					0	0	0	0	T	89705476	T	T	89705476	3	4	8	1	0	0	0	0	1	0	0	0	3291	826	29	2	520	2	CETN3	5	89705476	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	8091483	89705476	91209784	179	2068											
NR2F1	7025	broad.mit.edu	37	chr5	92929548	92929548	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtccatccagtgctcctaGaccttgggcgcttcccacct	6	11	8	16	1	0	1	0	0	0	1	4	1	4	1	6	1	1	2	6	1	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:92929548G>C	uc003kkj.2	+	3	2959	c.1272G>C	c.(1270-1272)TAG>TAC	p.*424Y		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	424					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		AGTGCTCCTAGACCTTGGGCG	0.597													8	85					0	0	0	0	C	92929548	C	C	92929548	4	2	8	1	0	0	0	0	0	0	0	0	10681	937	33	2	1282	2	NR2F1	5	92929548	Nonstop_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3224072	92929548	87985712	180	2069											
FBN2	2201	broad.mit.edu	37	chr5	127654636	127654636	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatgcaatgaaacattccaGgcaggttattacatgttcca	14	11	8	8	0	0	2	0	1	0	1	2	2	2	2	2	2	3	4	2	2	4	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:127654636G>C	uc003kuu.2	-	35	4968	c.4529C>G	c.(4528-4530)CCT>CGT	p.P1510R		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1510	EGF-like 25; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AAACATTCCAGGCAGGTTATT	0.358													5	113					0	0	0	0	C	127654636	C	C	127654636	3	2	8	1	0	0	0	0	1	0	0	0	5735	1000	35	4	4333	4	FBN2	5	127654636	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	34725088	127654636	53260624	181	2070											
SLC27A6	28965	broad.mit.edu	37	chr5	128364098	128364098	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttattggaatgttggatttCatacaggaagcaaacgtcta	13	13	10	5	1	2	0	1	0	1	0	2	3	2	3	0	3	3	3	0	3	6	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:128364098C>T	uc003kuy.2	+	9	1911	c.1515C>T	c.(1513-1515)TTC>TTT	p.F505F	SLC27A6_uc003kuz.2_Silent_p.F505F	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	505					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TGTTGGATTTCATACAGGAAG	0.343													18	68					0	0	0	0	T	128364098	T	T	128364098	2	4	8	1	0	0	0	0	0	0	0	1	14594	825	29	2		2	SLC27A6	5	128364098	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	709462	128364098	52551162	182	2071											
SPOCK1	6695	broad.mit.edu	37	chr5	136403477	136403477	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcccatcacagagggtggcGaggcttttgccagtagaaca	10	7	14	10	1	1	2	1	0	0	2	1	3	1	2	2	4	2	2	2	4	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:136403477G>A	uc003lbo.2	-	5	707	c.516C>T	c.(514-516)CTC>CTT	p.L172L	SPOCK1_uc003lbp.2_Silent_p.L172L	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	172	Kazal-like.				cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGAGGGTGGCGAGGCTTTTGC	0.527													48	159					0	0	0	0	A	136403477	A	A	136403477	2	1	8	1	0	0	0	0	0	0	0	1	15145	1045	37	1		1	SPOCK1	5	136403477	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8039379	136403477	44511783	183	2072											
KLHL3	26249	broad.mit.edu	37	chr5	136964011	136964011	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcgccggcacatgttcatGtctgccacttgcttccaggt	5	13	10	13	2	2	0	1	0	1	0	3	0	3	0	3	2	3	3	3	2	0	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:136964011G>A	uc010jek.2	-	13	2010	c.1566C>T	c.(1564-1566)GAC>GAT	p.D522D	KLHL3_uc011cyc.1_Silent_p.D257D|KLHL3_uc003lbr.3_Silent_p.D440D|KLHL3_uc011cyd.1_RNA	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	522	Kelch 5.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		ACATGTTCATGTCTGCCACTT	0.547													29	195					0	0	0	0	A	136964011	A	A	136964011	2	1	8	1	0	0	0	0	0	0	0	1	8422	1368	48	4		4	KLHL3	5	136964011	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	560534	136964011	43951249	184	2073											
KLHL3	26249	broad.mit.edu	37	chr5	137028128	137028128	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcagcaagctggctgccggGagcagcacctgcaagagaag	11	4	15	11	1	0	1	0	0	0	1	0	3	0	2	2	2	7	7	2	2	3	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:137028128G>A	uc010jek.2	-	5	816	c.372C>T	c.(370-372)CTC>CTT	p.L124L	KLHL3_uc003lbr.3_Silent_p.L42L|KLHL3_uc011cyd.1_RNA|MYOT_uc011cye.1_Intron|KLHL3_uc010jem.1_Silent_p.L84L|KLHL3_uc010jen.1_RNA|KLHL3_uc003lbs.1_5'UTR	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	124						cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		TGGCTGCCGGGAGCAGCACCT	0.527													8	43					0	0	0	0	A	137028128	A	A	137028128	2	1	8	1	0	0	0	0	0	0	0	1	8422	1161	41	2		2	KLHL3	5	137028128	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	64117	137028128	43887132	185	2074											
BRD8	10902	broad.mit.edu	37	chr5	137497522	137497522	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagccaggtgctatgtcatCtgtaacaggctgcaggaaga	11	9	13	8	0	2	1	1	0	1	1	2	2	2	2	1	3	4	5	1	3	4	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:137497522C>T	uc003lcf.1	-	17	2267	c.2212G>A	c.(2212-2214)GAT>AAT	p.D738N	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Missense_Mutation_p.D517N|BRD8_uc003lcg.2_Missense_Mutation_p.D811N|BRD8_uc003lci.2_Missense_Mutation_p.D741N|BRD8_uc003lch.2_Missense_Mutation_p.D632N|BRD8_uc011cym.1_Missense_Mutation_p.D722N|BRD8_uc010jer.1_Missense_Mutation_p.D707N|BRD8_uc011cyn.1_Missense_Mutation_p.D697N	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	738	Bromo 1.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCTATGTCATCTGTAACAGGC	0.463													16	65					0	0	0	0	T	137497522	T	T	137497522	3	4	8	1	0	0	0	0	1	0	0	0	1511	913	32	2	1603	2	BRD8	5	137497522	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	469394	137497522	43417738	186	2075											
KDM3B	51780	broad.mit.edu	37	chr5	137754821	137754821	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaatagcaatagtgaactGaaagccatcaggcctccttg	14	9	8	10	0	2	2	2	2	0	0	3	2	3	2	3	1	3	1	3	1	6	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:137754821G>A	uc003lcy.1	+	14	3815	c.3615G>A	c.(3613-3615)CTG>CTA	p.L1205L	KDM3B_uc010jew.1_Silent_p.L861L|KDM3B_uc011cys.1_Silent_p.L237L	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1205					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						ATAGTGAACTGAAAGCCATCA	0.522													20	50					0	0	0	0	A	137754821	A	A	137754821	2	1	8	1	0	0	0	0	0	0	0	1	8166	1277	45	2		2	KDM3B	5	137754821	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	257299	137754821	43160439	187	2076											
PCDHA10	56139	broad.mit.edu	37	chr5	140236754	140236754	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattgccctaatcagcgtttCtgaccatgattcaggagcca	10	11	8	12	1	3	2	2	2	1	0	3	3	3	3	3	1	3	1	3	1	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:140236754C>G	uc003lhx.2	+	1	1121	c.1121C>G	c.(1120-1122)TCT>TGT	p.S374C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.S374C|PCDHA10_uc011dad.1_Missense_Mutation_p.S374C	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	374	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCAGCGTTTCTGACCATGAT	0.488													33	133					0	0	0	0	G	140236754	G	G	140236754	3	3	8	1	0	0	0	0	1	0	0	0	11574	913	32	2	1123	2	PCDHA10	5	140236754	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2481933	140236754	40678506	188	2077											
PCDHA10	56139	broad.mit.edu	37	chr5	140236766	140236766	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcgtttctgaccatgattCaggagccaacggacaggtca	11	8	11	11	2	3	2	2	2	1	0	3	4	3	4	2	3	3	1	2	3	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:140236766C>T	uc003lhx.2	+	1	1133	c.1133C>T	c.(1132-1134)TCA>TTA	p.S378L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.S378L|PCDHA10_uc011dad.1_Missense_Mutation_p.S378L	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	378	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCATGATTCAGGAGCCAAC	0.512													32	136					0	0	0	0	T	140236766	T	T	140236766	3	4	8	1	0	0	0	0	1	0	0	0	11574	838	29	2	1135	2	PCDHA10	5	140236766	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	12	140236766	40678494	189	2078											
PCDHGA7	56108	broad.mit.edu	37	chr5	140764372	140764372	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcgggccctgctggacagaGatgccctcaagcagagcctc	8	6	12	15	1	1	2	1	0	0	2	3	4	1	3	3	2	4	2	3	2	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:140764372G>C	uc003lka.1	+	1	1906	c.1906G>C	c.(1906-1908)GAT>CAT	p.D636H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.D636H	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	636	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGACAGAGATGCCCTCAA	0.652													16	46					0	0	0	0	C	140764372	C	C	140764372	3	2	8	1	0	0	0	0	1	0	0	0	11613	942	33	2	1908	2	PCDHGA7	5	140764372	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	527606	140764372	40150888	190	2079											
PCDHGA8	9708	broad.mit.edu	37	chr5	140774356	140774356	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctctctccgccactgtcaCgctcaccgtagccgtggctg	4	9	9	19	4	3	0	2	0	1	0	5	0	4	0	5	1	1	3	5	1	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:140774356C>T	uc003lkd.1	+	1	2874	c.1976C>T	c.(1975-1977)ACG>ATG	p.T659M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.T659M	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	659	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACTGTCACGCTCACCGTA	0.642													10	36					0	0	0	0	T	140774356	T	T	140774356	3	4	8	1	0	0	0	0	1	0	0	0	11614	536	19	1	1978	1	PCDHGA8	5	140774356	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	9984	140774356	40140904	191	2080											
PCDHGA10	56106	broad.mit.edu	37	chr5	140793078	140793078	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgcgtggtgagttttaatatCcttgtggaagacagggtgaa	10	13	14	4	1	0	3	0	2	0	1	1	4	1	4	1	3	1	1	1	3	4	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:140793078C>G	uc003lkl.1	+	1	336	c.336C>G	c.(334-336)ATC>ATG	p.I112M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.I112M	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	112	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTTAATATCCTTGTGGAAG	0.488													42	99					0	0	0	0	G	140793078	G	G	140793078	3	3	8	1	0	0	0	0	1	0	0	0	11605	845	30	2	338	2	PCDHGA10	5	140793078	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	18722	140793078	40122182	192	2081											
ARHGAP26	23092	broad.mit.edu	37	chr5	142283207	142283207	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccatcagtccctacaccatgGagggatacctctacgtgcag	10	8	9	14	1	2	0	1	0	1	0	3	2	3	2	4	2	4	1	4	2	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:142283207G>T	uc011dbj.1	+	8	840	c.805G>T	c.(805-807)GAG>TAG	p.E269*	ARHGAP26_uc003lmt.2_Nonsense_Mutation_p.E269*|ARHGAP26_uc003lmw.2_Nonsense_Mutation_p.E269*	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	269	PH.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTACACCATGGAGGGATACCT	0.473													22	73					2.89027e-11	3.04442e-11	1	0	T	142283207	T	T	142283207	4	4	8	1	0	0	0	0	0	1	0	0	875	1175	41	2	835	2	ARHGAP26	5	142283207	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1490129	142283207	38632053	193	2082											
SLC36A2	153201	broad.mit.edu	37	chr5	150723127	150723127	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcatacagtggcaggcaatGaagcccatcaccagcagact	13	6	10	12	0	1	2	1	1	0	1	1	2	1	2	2	2	4	4	2	2	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:150723127G>A	uc003lty.2	-	3	418	c.288C>T	c.(286-288)TTC>TTT	p.F96F	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_5'UTR|SLC36A2_uc010jhv.2_Silent_p.F96F|SLC36A2_uc011dct.1_Silent_p.F96F	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	96	Helical; (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCAGGCAATGAAGCCCATCA	0.527													31	109					0	0	0	0	A	150723127	A	A	150723127	2	1	8	1	0	0	0	0	0	0	0	1	14658	1281	45	2		2	SLC36A2	5	150723127	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8439920	150723127	30192133	194	2083											
G3BP1	10146	broad.mit.edu	37	chr5	151169928	151169928	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtccatgggggattggattCaaatggaaagccagcagatg	12	9	14	6	0	1	1	1	0	0	1	2	4	2	4	2	4	2	1	2	4	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:151169928C>G	uc003lun.2	+	3	311	c.140C>G	c.(139-141)TCA>TGA	p.S47*	G3BP1_uc010jhy.1_Nonsense_Mutation_p.S47*|G3BP1_uc003lum.2_Nonsense_Mutation_p.S47*|G3BP1_uc011dcu.1_5'UTR|G3BP1_uc010jhz.2_5'UTR	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	47	NTF2.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			GGATTGGATTCAAATGGAAAG	0.343													6	30					0	0	0	0	G	151169928	G	G	151169928	4	3	8	1	0	0	0	0	0	1	0	0	6175	838	29	2	146	2	G3BP1	5	151169928	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	446801	151169928	29745332	195	2084											
SLIT3	6586	broad.mit.edu	37	chr5	168127613	168127613	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatccttgtggctgtcactCaggtggcaggtgcctccatg	5	11	12	13	0	2	0	2	0	0	0	4	0	4	0	4	4	1	2	4	4	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:168127613C>G	uc003mab.2	-	27	3336	c.2916G>C	c.(2914-2916)CTG>CTC	p.L972L	SLIT3_uc010jjg.2_Silent_p.L979L	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	972	EGF-like 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGCTGTCACTCAGGTGGCAGG	0.453													27	71					0	0	0	0	G	168127613	G	G	168127613	2	3	8	1	0	0	0	0	0	0	0	1	14805	813	29	2		2	SLIT3	5	168127613	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	16957685	168127613	12787647	196	2085											
GPRIN1	114787	broad.mit.edu	37	chr5	176026363	176026363	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtggaatcggcctgctttGaggacttgaaatccatcttc	10	12	10	9	1	1	2	0	2	1	0	4	4	2	4	2	3	1	1	2	3	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:176026363G>C	uc003meo.1	-	2	648	c.473C>G	c.(472-474)TCA>TGA	p.S158*		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	158						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCCTGCTTTGAGGACTTGAA	0.502													42	108					0	0	0	0	C	176026363	C	C	176026363	4	2	8	1	0	0	0	0	0	1	0	0	6768	1294	45	2	2557	2	GPRIN1	5	176026363	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	7898750	176026363	4888897	197	2086											
ZFP2	80108	broad.mit.edu	37	chr5	178358745	178358745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acacttcattgaacgatcctCccttactgtacatcaaagaa	14	11	4	12	1	2	2	2	1	0	1	4	3	4	2	2	0	3	1	2	0	5	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:178358745C>T	uc003mjn.1	+	5	940	c.431C>T	c.(430-432)TCC>TTC	p.S144F	ZFP2_uc010jky.2_Missense_Mutation_p.S144F|ZFP2_uc010jkx.1_Missense_Mutation_p.S144F	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	144	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		GAACGATCCTCCCTTACTGTA	0.403													19	58					0	0	0	0	T	178358745	T	T	178358745	3	4	8	1	0	0	0	0	1	0	0	0	17708	855	30	2	433	2	ZFP2	5	178358745	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2332382	178358745	2556515	198	2087											
ZFP2	80108	broad.mit.edu	37	chr5	178359095	178359095	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatgcatcttattgtacatCagagaagccatactggagaa	14	10	9	8	0	2	2	1	0	1	2	2	4	2	2	1	1	4	3	1	1	5	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:178359095C>T	uc003mjn.1	+	5	1290	c.781C>T	c.(781-783)CAG>TAG	p.Q261*	ZFP2_uc010jky.2_Nonsense_Mutation_p.Q261*|ZFP2_uc010jkx.1_Nonsense_Mutation_p.Q261*	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	261	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		TATTGTACATCAGAGAAGCCA	0.398													23	76					0	0	0	0	T	178359095	T	T	178359095	4	4	8	1	0	0	0	0	0	1	0	0	17708	827	29	2	783	2	ZFP2	5	178359095	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	350	178359095	2556165	199	2088											
HLA-A	3105	broad.mit.edu	37	chr6	29910683	29910683	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatggagccgcgggcgccgTggatagagcaggaggggccg	7	3	22	9	5	0	1	0	0	0	1	0	5	0	5	3	7	2	1	3	7	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:29910683T>C	uc003nol.2	+	2	223	c.223T>C	c.(223-225)TGG>CGG	p.W75R	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Missense_Mutation_p.W75R|HLA-A_uc003noo.2_Missense_Mutation_p.W75R|HLA-A_uc010jrr.2_Missense_Mutation_p.W75R|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_Missense_Mutation_p.W47R|HLA-A_uc011dmc.1_5'UTR|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	75	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCGGGCGCCGTGGATAGAGCA	0.677									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			11	16					0	0	0	0	C	29910683	C	C	29910683	3	2	8	1	0	0	0	0	1	0	0	0	7234	1696	59	5	229	5	HLA-A	6	29910683	Missense_Mutation	SNP	T	TCGA-BA-5152-01A-02D-1870-08		29910683	141204384	200	2089											
EGFL8	80864	broad.mit.edu	37	chr6	32135415	32135415	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcgaccaggtgctgctgctgGaggagaggctaggtgcctgt	6	8	18	9	1	0	1	0	0	0	1	0	4	0	2	2	5	4	4	2	5	1	1	rs17853434		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:32135415G>C	uc003oab.1	+	8	875	c.817G>C	c.(817-819)GAG>CAG	p.E273Q	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Missense_Mutation_p.E273Q	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	273				E -> Q (in Ref. 6; AAH35574).		extracellular region|integral to membrane	calcium ion binding				0						GCTGCTGCTGGAGGAGAGGCT	0.612													23	28					0	0	0	0	C	32135415	C	C	32135415	3	2	8	1	0	0	0	0	1	0	0	0	4987	1175	41	2	843	2	EGFL8	6	32135415	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2224732	32135415	138979652	201	2090											
BRD2	6046	broad.mit.edu	37	chr6	32942323	32942323	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggattcgaaaaccctctctCttgtatgagggctttgagag	10	12	11	8	1	2	2	0	2	2	1	4	5	2	3	1	2	1	2	1	2	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:32942323C>T	uc003ocn.3	+	3	1815	c.114C>T	c.(112-114)CTC>CTT	p.L38L	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.L38L|BRD2_uc003ocp.3_5'UTR|BRD2_uc010juh.2_Silent_p.L38L	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	38					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						AACCCTCTCTCTTGTATGAGG	0.582													10	80					0	0	0	0	T	32942323	T	T	32942323	2	4	8	1	0	0	0	0	0	0	0	1	1507	900	32	2		2	BRD2	6	32942323	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	806908	32942323	138172744	202	2091											
ANKS1A	23294	broad.mit.edu	37	chr6	35027938	35027938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catcaggtttacggacgctgGagcagagtgtcggggagtgg	8	8	18	7	3	1	1	1	0	0	1	2	4	1	4	0	6	2	3	0	6	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:35027938G>A	uc003ojx.3	+	13	2234	c.2092G>A	c.(2092-2094)GAG>AAG	p.E698K	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Missense_Mutation_p.E238K|ANKS1A_uc010jvp.1_Missense_Mutation_p.E72K	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	698	SAM 1.					cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						ACGGACGCTGGAGCAGAGTGT	0.527													6	17					0	0	0	0	A	35027938	A	A	35027938	3	1	8	1	0	0	0	0	1	0	0	0	688	1175	41	2	2142	2	ANKS1A	6	35027938	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2085615	35027938	136087129	203	2092											
DEF6	50619	broad.mit.edu	37	chr6	35280429	35280429	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtggaagcgagggcacctGagaaggaactgggccgaacg	11	4	17	9	3	0	1	0	1	0	1	0	6	0	3	2	4	3	1	2	4	4	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:35280429G>A	uc003okk.2	+	5	726	c.687G>A	c.(685-687)CTG>CTA	p.L229L	DEF6_uc010jvs.2_Silent_p.L229L|DEF6_uc010jvt.2_Intron	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	229	PH.					cytoplasm|nucleus|plasma membrane					0						GAGGGCACCTGAGAAGGAACT	0.612													3	29					0	0	0	0	A	35280429	A	A	35280429	2	1	8	1	0	0	0	0	0	0	0	1	4403	1277	45	2		2	DEF6	6	35280429	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	252491	35280429	135834638	204	2093											
SRPK1	6732	broad.mit.edu	37	chr6	35888247	35888247	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttggggtacaagactcacttCctttgggctttgtccttctt	5	17	9	10	0	2	1	1	0	1	1	4	1	4	1	2	3	1	2	2	3	2	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:35888247C>T	uc003olj.2	-	2	195	c.72G>A	c.(70-72)AGG>AGA	p.R24R	SRPK1_uc003olh.2_5'UTR|SRPK1_uc003oli.2_5'UTR	NM_003137	NP_003128	Q96SB4	SRPK1_HUMAN	SFRS protein kinase 1	24					cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						AGACTCACTTCCTTTGGGCTT	0.542													59	102					0	0	0	0	T	35888247	T	T	35888247	2	4	8	1	0	0	0	0	0	0	0	1	15225	854	30	2		2	SRPK1	6	35888247	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	607818	35888247	135226820	205	2094											
STK38	11329	broad.mit.edu	37	chr6	36475338	36475338	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgtcctatgtgcttttttCagtcctgtgcaaagaccaaa	9	15	7	10	0	2	1	1	0	1	1	4	1	4	1	3	0	2	2	3	0	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:36475338C>T	uc003omg.2	-	7	1299	c.711G>A	c.(709-711)CTG>CTA	p.L237L	STK38_uc003omh.2_Silent_p.L237L|STK38_uc003omi.2_Silent_p.L237L	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	237	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						GTGCTTTTTTCAGTCCTGTGC	0.408													92	176					0	0	0	0	T	36475338	T	T	36475338	2	4	8	1	0	0	0	0	0	0	0	1	15369	813	29	2		2	STK38	6	36475338	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	587091	36475338	134639729	206	2095											
DNAH8	1769	broad.mit.edu	37	chr6	38791364	38791364	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggctaacaacccctctctGactgaaatcagatcagaaat	14	10	6	11	0	3	4	2	2	1	2	4	4	3	4	2	1	2	1	2	1	4	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:38791364G>C	uc003ooe.1	+	26	3696	c.3096G>C	c.(3094-3096)CTG>CTC	p.L1032L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ACCCCTCTCTGACTGAAATCA	0.318													11	61					0	0	0	0	C	38791364	C	C	38791364	2	2	8	1	0	0	0	0	0	0	0	1	4629	1277	45	2		2	DNAH8	6	38791364	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2316026	38791364	132323703	207	2096											
FOXP4	116113	broad.mit.edu	37	chr6	41552527	41552527	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcctgtgtcggtggccatGatgtcgccgcagatgcttac	5	11	14	11	3	0	2	0	1	0	1	2	2	0	2	3	2	3	2	3	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:41552527G>A	uc003oql.2	+	4	779	c.321G>A	c.(319-321)ATG>ATA	p.M107I	FOXP4_uc003oqm.2_Missense_Mutation_p.M107I|FOXP4_uc003oqn.2_Missense_Mutation_p.M107I	NM_001012426	NP_001012426	Q8IVH2	FOXP4_HUMAN	forkhead box P4 isoform 1	107	Gln-rich.				embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CGGTGGCCATGATGTCGCCGC	0.662													3	6					0	0	0	0	A	41552527	A	A	41552527	3	1	8	1	0	0	0	0	1	0	0	0	6063	1290	45	2	331	2	FOXP4	6	41552527	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2761163	41552527	129562540	208	2097											
TRERF1	55809	broad.mit.edu	37	chr6	42227372	42227372	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgggatgaagagaggttcCggccggtgccggaacttttt	7	9	17	8	4	0	2	0	1	0	1	1	5	1	4	3	6	2	1	3	6	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:42227372C>T	uc003osd.2	-	9	2537	c.1974G>A	c.(1972-1974)CCG>CCA	p.P658P	TRERF1_uc011duq.1_Silent_p.P575P|TRERF1_uc003osb.2_Silent_p.P414P|TRERF1_uc003osc.2_Silent_p.P414P|TRERF1_uc003ose.2_Silent_p.P678P	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	658	Pro-rich.|Interacts with CREBBP.			P -> S (in Ref. 2; CAB88206/CAB88207).	cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGAGAGGTTCCGGCCGGTGCC	0.652													21	66					0	0	0	0	T	42227372	T	T	42227372	2	4	8	1	0	0	0	0	0	0	0	1	16542	639	23	1		1	TRERF1	6	42227372	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	674845	42227372	128887695	209	2098											
YIPF3	25844	broad.mit.edu	37	chr6	43480834	43480834	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaacatctgcagcatggtGatctgggcgttgcacaggta	9	9	13	10	1	2	1	0	1	2	0	2	1	2	1	1	3	4	5	1	3	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:43480834G>A	uc003ovl.1	-	6	796	c.639C>T	c.(637-639)ATC>ATT	p.I213I	C6orf154_uc003ovk.1_5'Flank|YIPF3_uc011dvk.1_Silent_p.I178I|YIPF3_uc010jyr.1_Silent_p.I219I|YIPF3_uc010jys.1_Silent_p.I56I|YIPF3_uc003ovm.1_Silent_p.I87I|YIPF3_uc010jyt.1_Silent_p.I162I	NM_015388	NP_056203	Q9GZM5	YIPF3_HUMAN	natural killer cell-specific antigen KLIP1	213					cell differentiation	integral to membrane|plasma membrane|transport vesicle					0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GCAGCATGGTGATCTGGGCGT	0.562													52	154					0	0	0	0	A	43480834	A	A	43480834	2	1	8	1	0	0	0	0	0	0	0	1	17547	1280	45	2		2	YIPF3	6	43480834	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1253462	43480834	127634233	210	2099											
RUNX2	860	broad.mit.edu	37	chr6	45514677	45514677	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccagccacctttacttacAccccgccagtcacctcaggc	9	8	5	19	1	2	0	2	0	0	0	3	0	3	0	7	1	3	0	7	1	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:45514677A>C	uc011dvx.1	+	9	1411	c.1201A>C	c.(1201-1203)ACC>CCC	p.T401P	RUNX2_uc011dvy.1_Missense_Mutation_p.T379P|RUNX2_uc003oxt.2_Missense_Mutation_p.T387P	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	401	Interaction with MYST3 (By similarity).|Pro/Ser/Thr-rich.|Interaction with MYST4.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						CTTTACTTACACCCCGCCAGT	0.587													7	63					0	0	0	0	C	45514677	C	C	45514677	3	2	8	1	0	0	0	0	1	0	0	0	13813	159	6	5	1247	5	RUNX2	6	45514677	Missense_Mutation	SNP	A	TCGA-BA-5152-01A-02D-1870-08	2033843	45514677	125600390	211	2100											
GPR116	221395	broad.mit.edu	37	chr6	46851916	46851916	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggaggaagacgtcacgctCttgacaaatgagattgtgaa	13	9	13	6	2	2	4	1	3	1	2	2	7	2	6	0	2	0	1	0	2	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46851916C>G	uc003oyo.3	-	5	710	c.421G>C	c.(421-423)GAG>CAG	p.E141Q	GPR116_uc003oyp.3_Missense_Mutation_p.E141Q|GPR116_uc003oyq.3_Missense_Mutation_p.E141Q|GPR116_uc003oyr.2_Missense_Mutation_p.E141Q	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	141	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			ACGTCACGCTCTTGACAAATG	0.502													17	125					0	0	0	0	G	46851916	G	G	46851916	3	3	8	1	0	0	0	0	1	0	0	0	6671	922	32	2	3687	2	GPR116	6	46851916	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1337239	46851916	124263151	212	2101											
GPR110	266977	broad.mit.edu	37	chr6	46977116	46977116	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgatggaacacgaggatgatCcggtaagccagcaggatgcc	12	6	14	9	2	0	2	0	2	0	0	1	6	1	5	3	4	4	2	3	4	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977116C>T	uc003oyt.2	-	11	2254	c.2055G>A	c.(2053-2055)CGG>CGA	p.R685R	GPR110_uc011dwl.1_Silent_p.R373R	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	685	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CGAGGATGATCCGGTAAGCCA	0.483													15	47					0	0	0	0	T	46977116	T	T	46977116	2	4	8	1	0	0	0	0	0	0	0	1	6665	842	30	2		2	GPR110	6	46977116	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	125200	46977116	124137951	213	2102			2	4		10	9	627	N	C	1.087236e-20
GPR110	266977	broad.mit.edu	37	chr6	46977149	46977149	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggatgccaagcatgagcatCcagaagaacaaagagaggta	18	4	12	7	0	0	4	0	1	0	3	1	6	1	5	2	2	4	3	2	2	5	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977149C>T	uc003oyt.2	-	11	2221	c.2022G>A	c.(2020-2022)TGG>TGA	p.W674*	GPR110_uc011dwl.1_Nonsense_Mutation_p.W362*	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	674	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						GCATGAGCATCCAGAAGAACA	0.498													11	48					0	0	0	0	T	46977149	T	T	46977149	4	4	8	1	0	0	0	0	0	1	0	0	6665	856	30	2	730	2	GPR110	6	46977149	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	33	46977149	124137918	214	2103			2	4		10	9	627	N	C	1.087236e-20
GPR110	266977	broad.mit.edu	37	chr6	46977208	46977208	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagcagctgtgcagactcCagaagggttcaccgtggtgt	9	8	13	11	1	1	2	1	0	0	2	2	2	2	2	2	2	3	4	2	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977208C>T	uc003oyt.2	-	11	2162	c.1963G>A	c.(1963-1965)GGA>AGA	p.G655R	GPR110_uc011dwl.1_Missense_Mutation_p.G343R	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	655	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						GTGCAGACTCCAGAAGGGTTC	0.498													7	33					0	0	0	0	T	46977208	T	T	46977208	3	4	8	1	0	0	0	0	1	0	0	0	6665	603	21	4	789	4	GPR110	6	46977208	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	59	46977208	124137859	215	2104			2	4		10	9	627	N	C	1.087236e-20
GPR110	266977	broad.mit.edu	37	chr6	46977266	46977266	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataaaccagacatcagcaatCaagagggacagggctatgtt	16	7	10	8	0	2	2	2	0	0	2	2	3	2	3	1	2	2	3	1	2	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977266C>G	uc003oyt.2	-	11	2104	c.1905G>C	c.(1903-1905)TTG>TTC	p.L635F	GPR110_uc011dwl.1_Missense_Mutation_p.L323F	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	635	Helical; Name=2; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CATCAGCAATCAAGAGGGACA	0.468													8	40					0	0	0	0	G	46977266	G	G	46977266	3	3	8	1	0	0	0	0	1	0	0	0	6665	825	29	2	847	2	GPR110	6	46977266	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	58	46977266	124137801	216	2105			2	4		10	9	627	N	C	1.087236e-20
GPR110	266977	broad.mit.edu	37	chr6	46977332	46977332	+	Missense_Mutation	SNP	C	A	A																															gaggtttggctttttttaatCtgcttccaaaacaaagcctc																										TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977332C>A	uc003oyt.2	-	11	2038	c.1839G>T	c.(1837-1839)CAG>CAT	p.Q613H	GPR110_uc011dwl.1_Missense_Mutation_p.Q301H	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	613	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TTTTTTTAATCTGCTTCCAAA	0.443													10	50					3.86212e-05	3.94535e-05	1	0	A	46977332	A	A	46977332	3	1	8	1	0	0	0	0	1	0	0	0	6665	912	32	2	913	2	GPR110	6	46977332	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	66	46977332	124137735	217	2106	6	2	2	4		10	9	627	N	C	1.087236e-20
GPR110	266977	broad.mit.edu	37	chr6	46977338	46977338	+	Nonsense_Mutation	SNP	C	T	T																															tggctttttttaatctgcttCcaaaacaaagcctcgatgat																										TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977338C>T	uc003oyt.2	-	11	2032	c.1833G>A	c.(1831-1833)TGG>TGA	p.W611*	GPR110_uc011dwl.1_Nonsense_Mutation_p.W299*	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	611	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TAATCTGCTTCCAAAACAAAG	0.438													12	53					0	0	0	0	T	46977338	T	T	46977338	4	4	8	1	0	0	0	0	0	1	0	0	6665	856	30	2	919	2	GPR110	6	46977338	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	6	46977338	124137729	218	2107	6	2	2	4		10	9	627	N	C	1.087236e-20
GPR110	266977	broad.mit.edu	37	chr6	46977410	46977410	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccagtcccacataggtgatCcattttacaacggggaagat	12	9	9	11	1	0	2	0	1	0	1	2	3	2	3	3	3	2	0	3	3	4	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977410C>A	uc003oyt.2	-	11	1960	c.1761G>T	c.(1759-1761)TGG>TGT	p.W587C	GPR110_uc011dwl.1_Missense_Mutation_p.W275C	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	587	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CATAGGTGATCCATTTTACAA	0.433													18	91					5.26018e-13	5.58207e-13	1	0	A	46977410	A	A	46977410	3	1	8	1	0	0	0	0	1	0	0	0	6665	856	30	2	991	2	GPR110	6	46977410	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	72	46977410	124137657	219	2108			2	4		10	9	627	N	C	1.087236e-20
GPR110	266977	broad.mit.edu	37	chr6	46977535	46977535	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactaggtggcagcctgcatCgttccactgcaaatgactga	10	9	10	12	1	0	2	0	2	0	0	2	2	1	2	2	2	3	4	2	2	2	2	rs112946460		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977535C>T	uc003oyt.2	-	11	1835	c.1636G>A	c.(1636-1638)GAT>AAT	p.D546N	GPR110_uc011dwl.1_Missense_Mutation_p.D234N	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	546	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CAgcctgcatcgttccactgc	0.264													13	43					0	0	0	0	T	46977535	T	T	46977535	3	4	8	1	0	0	0	0	1	0	0	0	6665	884	31	1	1116	1	GPR110	6	46977535	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	125	46977535	124137532	220	2109			2	4		10	9	627	N	C	1.087236e-20
GPR110	266977	broad.mit.edu	37	chr6	46977656	46977656	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgaataaccgtggatatCacaggtccattgacctgagc	11	12	9	9	1	1	3	1	3	0	0	2	4	2	4	3	2	2	0	3	2	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977656C>G	uc003oyt.2	-	11	1714	c.1515G>C	c.(1513-1515)GTG>GTC	p.V505V	GPR110_uc011dwl.1_Silent_p.V193V	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	505	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CCGTGGATATCACAGGTCCAT	0.313													20	82					0	0	0	0	G	46977656	G	G	46977656	2	3	8	1	0	0	0	0	0	0	0	1	6665	813	29	2		2	GPR110	6	46977656	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	121	46977656	124137411	221	2110			2	4		10	9	627	N	C	1.087236e-20
GPR110	266977	broad.mit.edu	37	chr6	46977742	46977742	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccatgctgataatagtttCtggaagggatctctggaatt	10	13	12	6	0	2	1	0	1	2	0	3	4	2	4	1	4	1	2	1	4	4	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977742C>T	uc003oyt.2	-	11	1628	c.1429G>A	c.(1429-1431)GAA>AAA	p.E477K	GPR110_uc011dwl.1_Missense_Mutation_p.E165K	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	477	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						ATAATAGTTTCTGGAAGGGAT	0.443													22	77					0	0	0	0	T	46977742	T	T	46977742	3	4	8	1	0	0	0	0	1	0	0	0	6665	922	32	2	1323	2	GPR110	6	46977742	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	86	46977742	124137325	222	2111			2	4		10	9	627	N	C	1.087236e-20
CRISP3	10321	broad.mit.edu	37	chr6	49698947	49698947	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcataagggacatatagtCtattagcccaattaccactg	13	12	7	9	0	2	0	1	0	1	0	2	1	2	1	2	1	2	1	2	1	7	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:49698947C>T	uc003ozs.2	-	7	554	c.539G>A	c.(538-540)AGA>AAA	p.R180K		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	180					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GACATATAGTCTATTAGCCCA	0.333													17	54					0	0	0	0	T	49698947	T	T	49698947	3	4	8	1	0	0	0	0	1	0	0	0	3896	913	32	2	206	2	CRISP3	6	49698947	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2721205	49698947	121416120	223	2112											
SENP6	26054	broad.mit.edu	37	chr6	76407199	76407199	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccggcacgtagatatttttGagaaggattttatttttgta	10	17	9	5	2	0	2	0	1	0	2	0	4	0	3	1	2	0	3	1	2	5	9			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:76407199G>C	uc003pid.3	+	18	2873	c.2254G>C	c.(2254-2256)GAG>CAG	p.E752Q	SENP6_uc003pie.3_Missense_Mutation_p.E745Q|SENP6_uc010kbf.2_RNA	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	752	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				AGATATTTTTGAGAAGGATTT	0.303													10	25					0	0	0	0	C	76407199	C	C	76407199	3	2	8	1	0	0	0	0	1	0	0	0	14115	1291	45	2	2324	2	SENP6	6	76407199	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	26708252	76407199	94707868	224	2113											
TCF21	6943	broad.mit.edu	37	chr6	134212923	134212923	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaccgcgagccgcttatgtGgaaccaccgcgtcctgacct	7	8	11	15	5	0	2	0	2	0	0	1	4	1	3	6	1	2	1	6	1	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:134212923G>A	uc003qei.3	+	2	799	c.523G>A	c.(523-525)GGA>AGA	p.G175R	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Missense_Mutation_p.G175R	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	175					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		CCGCTTATGTGGAACCACCGC	0.657													11	34					0	0	0	0	A	134212923	A	A	134212923	3	1	8	1	0	0	0	0	1	0	0	0	15757	1349	47	4	529	4	TCF21	6	134212923	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	57805724	134212923	36902144	225	2114											
HECA	51696	broad.mit.edu	37	chr6	139487747	139487747	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtgaagcggatgcaggacGagaaaaagaagaagtctggc	16	4	16	5	2	1	4	0	1	1	3	1	7	1	6	0	4	2	1	0	4	5	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:139487747G>A	uc003qin.2	+	2	883	c.598G>A	c.(598-600)GAG>AAG	p.E200K		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	200					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		GATGCAGGACGAGAAAAAGAA	0.582													37	45					0	0	0	0	A	139487747	A	A	139487747	3	1	8	1	0	0	0	0	1	0	0	0	7077	1059	37	1	604	1	HECA	6	139487747	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5274824	139487747	31627320	226	2115											
MICALL2	79778	broad.mit.edu	37	chr7	1479682	1479682	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgggggcctcccccgccctCggctctgccagggcccgtgg	1	6	15	19	3	1	0	0	0	1	0	3	0	2	0	6	5	1	1	6	5	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:1479682C>T	uc003skj.3	-	9	1992	c.1845G>A	c.(1843-1845)CCG>CCA	p.P615P	MICALL2_uc003skh.3_5'Flank|MICALL2_uc003ski.3_Silent_p.P102P	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	615						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		CCCCCGCCCTCGGCTCTGCCA	0.687													28	61					0	0	0	0	T	1479682	T	T	1479682	2	4	8	1	0	0	0	0	0	0	0	1	9627	871	31	1		1	MICALL2	7	1479682	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08		1479682	157658981	227	2116											
KIAA0415	9907	broad.mit.edu	37	chr7	4830913	4830913	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcacacccagcacggaggTgtgcagcccccgctatcacc	8	5	10	18	2	2	0	2	0	0	0	2	1	2	1	4	2	3	4	4	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:4830913T>A	uc003sne.2	+	17	2404	c.2321T>A	c.(2320-2322)GTG>GAG	p.V774E	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_Missense_Mutation_p.V251E	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	774					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		AGCACGGAGGTGTGCAGCCCC	0.697													8	21					0	0	0	0	A	4830913	A	A	4830913	3	1	8	1	0	0	0	0	1	0	0	0	8214	1696	59	5	2387	5	KIAA0415	7	4830913	Missense_Mutation	SNP	T	TCGA-BA-5152-01A-02D-1870-08	3351231	4830913	154307750	228	2117											
GLCCI1	113263	broad.mit.edu	37	chr7	8062158	8062158	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcagaaaagaggtcacatCagcgttctgcgtcatggggg	10	8	15	8	2	4	2	3	0	1	2	4	2	4	2	0	3	3	2	0	3	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:8062158C>A	uc003srk.2	+	3	1214	c.655C>A	c.(655-657)CAG>AAG	p.Q219K		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	219											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		GAGGTCACATCAGCGTTCTGC	0.363													7	99					5.18039e-06	5.35357e-06	1	0	A	8062158	A	A	8062158	3	1	8	1	0	0	0	0	1	0	0	0	6468	827	29	2	665	2	GLCCI1	7	8062158	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3231245	8062158	151076505	229	2118											
DNAH11	8701	broad.mit.edu	37	chr7	21695520	21695520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagacaatcaggatgtttCtgcacacagggcagttggaa	13	9	12	7	0	2	2	1	1	1	1	2	4	2	4	0	3	1	4	0	3	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:21695520C>T	uc003svc.2	+	29	5061	c.5030C>T	c.(5029-5031)TCT>TTT	p.S1677F		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1677	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CAGGATGTTTCTGCACACAGG	0.403									Kartagener_syndrome				7	49					0	0	0	0	T	21695520	T	T	21695520	3	4	8	1	0	0	0	0	1	0	0	0	4621	913	32	2	5144	2	DNAH11	7	21695520	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	13633362	21695520	137443143	230	2119											
VPS41	27072	broad.mit.edu	37	chr7	38785177	38785177	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcagaagataaactgtctCttctacaaagtttctctgtt	12	15	5	9	0	4	2	1	0	3	2	6	2	4	2	0	0	2	2	0	0	5	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:38785177C>G	uc003tgy.2	-	23	1989	c.1963G>C	c.(1963-1965)GAG>CAG	p.E655Q	VPS41_uc003tgz.2_Missense_Mutation_p.E630Q|VPS41_uc010kxn.2_Missense_Mutation_p.E566Q|VPS41_uc003tgx.2_RNA	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	655	Clathrin.				Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TAAACTGTCTCTTCTACAAAG	0.338													45	154					0	0	0	0	G	38785177	G	G	38785177	3	3	8	1	0	0	0	0	1	0	0	0	17278	922	32	2	629	2	VPS41	7	38785177	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	17089657	38785177	120353486	231	2120											
POM121L12	285877	broad.mit.edu	37	chr7	53103800	53103800	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcgggatcgcgccccctgagCgtcaggagagcccctggaga	7	5	15	14	4	1	3	1	1	0	2	3	6	1	4	4	3	2	0	4	3	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:53103800C>T	uc003tpz.2	+	1	452	c.436C>T	c.(436-438)CGT>TGT	p.R146C		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	146											0						GCCCCCTGAGCGTCAGGAGAG	0.577													13	29					0	0	0	0	T	53103800	T	T	53103800	3	4	8	1	0	0	0	0	1	0	0	0	12296	768	27	1	438	1	POM121L12	7	53103800	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	14318623	53103800	106034863	232	2121											
HGF	3082	broad.mit.edu	37	chr7	81334827	81334827	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttatatagagatgtgccactCgtaataggccatcatagttg	12	13	9	7	1	1	1	1	0	0	1	2	2	1	1	2	1	1	2	2	1	6	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:81334827C>G	uc003uhl.2	-	17	2054	c.1889G>C	c.(1888-1890)CGA>CCA	p.R630P	HGF_uc003uhm.2_Missense_Mutation_p.R625P	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	630	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						ATGTGCCACTCGTAATAGGCC	0.368													8	53					0	0	0	0	G	81334827	G	G	81334827	3	3	8	1	0	0	0	0	1	0	0	0	7124	884	31	3	305	3	HGF	7	81334827	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	28231027	81334827	77803836	233	2122											
PCLO	27445	broad.mit.edu	37	chr7	82583504	82583504	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atatgatcagcactagctctAccatctggtggggcagtccg	9	10	11	11	1	3	1	1	1	2	0	4	1	4	1	2	3	3	3	2	3	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:82583504A>C	uc003uhx.2	-	5	7054	c.6765T>G	c.(6763-6765)GGT>GGG	p.G2255G	PCLO_uc003uhv.2_Silent_p.G2255G|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2186					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CACTAGCTCTACCATCTGGTG	0.393													9	76					0	0	0	0	C	82583504	C	C	82583504	2	2	8	1	0	0	0	0	0	0	0	1	11637	378	14	5		5	PCLO	7	82583504	Silent	SNP	A	TCGA-BA-5152-01A-02D-1870-08	1248677	82583504	76555159	234	2123											
ABCB4	5244	broad.mit.edu	37	chr7	87072722	87072722	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttccaaccagggccaccgtCtgcccactctgcaccttcag	7	8	7	19	1	3	0	1	0	2	0	4	0	4	0	6	1	3	1	6	1	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:87072722C>T	uc003uiv.1	-	12	1345	c.1269G>A	c.(1267-1269)CAG>CAA	p.Q423Q	ABCB4_uc003uiw.1_Silent_p.Q423Q|ABCB4_uc003uix.1_Silent_p.Q423Q	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	423	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GGGCCACCGTCTGCCCACTCT	0.493													10	84					0	0	0	0	T	87072722	T	T	87072722	2	4	8	1	0	0	0	0	0	0	0	1	43	912	32	2		2	ABCB4	7	87072722	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4489218	87072722	72065941	235	2124											
DYNC1I1	1780	broad.mit.edu	37	chr7	95434085	95434085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agctgagctagagcgcaaaaAgcagcgcttagcacagataa	16	5	11	9	2	0	3	0	1	0	2	0	3	0	3	0	0	6	6	0	0	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:95434085A>G	uc003uoc.3	+	2	321	c.44A>G	c.(43-45)AAG>AGG	p.K15R	DYNC1I1_uc003uod.3_Missense_Mutation_p.K15R|DYNC1I1_uc003uob.2_Missense_Mutation_p.K15R|DYNC1I1_uc003uoe.3_Missense_Mutation_p.K15R|DYNC1I1_uc010lfl.2_Missense_Mutation_p.K21R	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	15	Interaction with DCTN1 (By similarity).				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			GAGCGCAAAAAGCAGCGCTTA	0.294													3	5					0	0	0	0	G	95434085	G	G	95434085	3	3	8	1	0	0	0	0	1	0	0	0	4864	72	3	5	46	5	DYNC1I1	7	95434085	Missense_Mutation	SNP	A	TCGA-BA-5152-01A-02D-1870-08	8361363	95434085	63704578	236	2125											
ZAN	7455	broad.mit.edu	37	chr7	100350144	100350144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagagcccaccacccccactGaggagaccaccatctccaca	13	3	6	19	0	1	3	0	1	1	2	2	4	1	3	7	1	1	0	7	1	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:100350144G>A	uc003uwj.2	+	14	2581	c.2416G>A	c.(2416-2418)GAG>AAG	p.E806K	ZAN_uc003uwk.2_Missense_Mutation_p.E806K|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	806	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CACCCCCACTGAGGAGACCAC	0.527													9	74					0	0	0	0	A	100350144	A	A	100350144	3	1	8	1	0	0	0	0	1	0	0	0	17581	1291	45	2	2466	2	ZAN	7	100350144	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4916059	100350144	58788519	237	2126											
CUX1	1523	broad.mit.edu	37	chr7	101813790	101813790	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gctctcatcggccaatcactCcctccagctggcctcacaga	8	8	7	18	1	3	1	3	0	1	1	7	1	5	1	4	2	1	2	4	2	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:101813790C>G	uc003uyx.3	+	10	826	c.788C>G	c.(787-789)TCC>TGC	p.S263C	CUX1_uc003uys.3_Missense_Mutation_p.S274C|CUX1_uc003uyt.2_Missense_Mutation_p.S274C|CUX1_uc011kkn.1_Missense_Mutation_p.S237C|CUX1_uc003uyw.2_Missense_Mutation_p.S228C|CUX1_uc003uyv.2_Missense_Mutation_p.S258C|CUX1_uc003uyu.2_Missense_Mutation_p.S274C	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	263	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GCCAATCACTCCCTCCAGCTG	0.602													2	7					0	0	0	0	G	101813790	G	G	101813790	3	3	8	1	0	0	0	0	1	0	0	0	4081	855	30	2	893	2	CUX1	7	101813790	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1463646	101813790	57324873	238	2127											
ALKBH4	54784	broad.mit.edu	37	chr7	102100194	102100194	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagccctcaaagtcagactCctctgtgcccacggcccagc	8	6	8	19	1	3	1	2	0	1	1	4	1	4	1	5	1	3	0	5	1	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:102100194C>A	uc003uzl.2	-	2	183	c.178G>T	c.(178-180)GAG>TAG	p.E60*	ALKBH4_uc003uzm.2_Intron	NM_017621	NP_060091	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4	60						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AAGTCAGACTCCTCTGTGCCC	0.493													13	77					1.49906e-05	1.54022e-05	1	0	A	102100194	A	A	102100194	4	1	8	1	0	0	0	0	0	1	0	0	529	864	30	2	738	2	ALKBH4	7	102100194	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	286404	102100194	57038469	239	2128											
PUS7	54517	broad.mit.edu	37	chr7	105146708	105146708	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttcctatttcatgaacaacGaagtcggagtatctgatgaa	13	13	8	7	2	2	3	1	3	1	0	4	5	3	4	1	1	2	1	1	1	6	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:105146708G>A	uc003vcx.2	-	3	630	c.411C>T	c.(409-411)TTC>TTT	p.F137F	PUS7_uc010lji.2_Silent_p.F137F|PUS7_uc003vcy.2_Silent_p.F137F|PUS7_uc003vcz.1_Silent_p.F137F	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	137					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						CATGAACAACGAAGTCGGAGT	0.363													7	34					0	0	0	0	A	105146708	A	A	105146708	2	1	8	1	0	0	0	0	0	0	0	1	12898	1049	37	1		1	PUS7	7	105146708	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3046514	105146708	53991955	240	2129											
NAMPT	10135	broad.mit.edu	37	chr7	105893498	105893498	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaggtctccttttccttcctCcagtgtaacaaaattccctg	9	14	5	13	0	1	0	0	0	1	0	6	0	5	0	5	1	1	1	5	1	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:105893498C>G	uc003vdq.2	-	10	1638	c.1330G>C	c.(1330-1332)GAG>CAG	p.E444Q		NM_005746	NP_005737	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	444					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			large_intestine(1)	1						TTTCCTTCCTCCAGTGTAACA	0.408													10	55					0	0	0	0	G	105893498	G	G	105893498	3	3	8	1	0	0	0	0	1	0	0	0	10202	864	30	2	153	2	NAMPT	7	105893498	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	746790	105893498	53245165	241	2130											
FOXP2	93986	broad.mit.edu	37	chr7	114329955	114329955	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgacagagagattgaagaaGagcctttatctgaagatctg	15	9	11	6	1	2	7	0	2	2	5	2	9	2	7	1	0	1	0	1	0	4	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:114329955G>A	uc003vhb.2	+	17	2496	c.2122G>A	c.(2122-2124)GAG>AAG	p.E708K	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.E733K|FOXP2_uc003vha.2_Missense_Mutation_p.E616K|FOXP2_uc011kmu.1_Missense_Mutation_p.E725K|FOXP2_uc011kmv.1_Missense_Mutation_p.E707K|FOXP2_uc010ljz.1_Missense_Mutation_p.E523K	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	708					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						GATTGAAGAAGAGCCTTTATC	0.438													9	60					0	0	0	0	A	114329955	A	A	114329955	3	1	8	1	0	0	0	0	1	0	0	0	6061	943	33	2	2351	2	FOXP2	7	114329955	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8436457	114329955	44808708	242	2131											
CADPS2	93664	broad.mit.edu	37	chr7	122261717	122261717	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcactgaagaccgcaactCttctatatacatattctcca	13	13	3	12	1	4	2	1	1	3	1	5	2	4	2	2	0	2	1	2	0	6	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:122261717C>G	uc010lkp.2	-	5	1085	c.922G>C	c.(922-924)GAG>CAG	p.E308Q	CADPS2_uc003vkg.3_Missense_Mutation_p.E8Q|CADPS2_uc010lkq.2_Missense_Mutation_p.E308Q	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	308					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						GACCGCAACTCTTCTATATAC	0.299													9	48					0	0	0	0	G	122261717	G	G	122261717	3	3	8	1	0	0	0	0	1	0	0	0	2583	922	32	2	3116	2	CADPS2	7	122261717	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7931762	122261717	36876946	243	2132											
RBM28	55131	broad.mit.edu	37	chr7	127975631	127975631	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctcagtgctggtatcactCtgagccagttcctctccatc	6	13	7	15	0	4	1	2	1	2	0	8	1	6	1	4	1	2	3	4	1	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:127975631C>G	uc003vmp.2	-	8	1027	c.912G>C	c.(910-912)CAG>CAC	p.Q304H	RBM28_uc003vmo.2_5'UTR|RBM28_uc011koj.1_Missense_Mutation_p.Q163H|RBM28_uc011kok.1_Missense_Mutation_p.Q251H	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	304					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						TGGTATCACTCTGAGCCAGTT	0.423													5	37					0	0	0	0	G	127975631	G	G	127975631	3	3	8	1	0	0	0	0	1	0	0	0	13193	912	32	2	1415	2	RBM28	7	127975631	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5713914	127975631	31163032	244	2133											
NUP205	23165	broad.mit.edu	37	chr7	135289087	135289087	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgttttcttttctttaaaGatacctatatcatggcaata	13	18	4	6	0	3	1	1	0	2	1	3	1	3	1	1	1	1	2	1	1	8	10			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:135289087G>C	uc003vsw.2	+	19	2734	c.2703_splice	c.e19-1	p.R901_splice		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						TTTCTTTAAAGATACCTATAT	0.279													7	23					0	0	0	0	C	135289087	C	C	135289087	5	2	8	1	0	0	0	0	0	0	1	0	10813	956	33	2	2776	2	NUP205	7	135289087	Splice_Site	SNP	G	TCGA-BA-5152-01A-02D-1870-08	7313456	135289087	23849576	245	2134											
BRAF	673	broad.mit.edu	37	chr7	140453110	140453110	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccagacaactgttcaaactGatgggacccactccatcgag	12	8	8	13	1	1	2	1	1	0	1	4	4	3	3	3	1	2	1	3	1	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:140453110G>C	uc003vwc.3	-	15	1886	c.1825C>G	c.(1825-1827)CAG>GAG	p.Q609E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	609	Protein kinase.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.Q609R(1)|p.Q609Q(1)|p.Q609*(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TGTTCAAACTGATGGGACCCA	0.393		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				10	52					0	0	0	0	C	140453110	C	C	140453110	3	2	8	1	0	0	0	0	1	0	0	0	1501	1299	45	2	491	2	BRAF	7	140453110	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5164023	140453110	18685553	246	2135											
CUL1	8454	broad.mit.edu	37	chr7	148495716	148495716	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgaaaaccgaacagaagcagGaacaagaaaccacacacaaa	23	1	7	10	1	0	3	0	1	0	2	0	5	0	4	2	1	5	1	2	1	8	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:148495716G>T	uc010lpg.2	+	20	2609	c.2083G>T	c.(2083-2085)GAA>TAA	p.E695*	CUL1_uc003wey.2_Nonsense_Mutation_p.E695*|CUL1_uc003wez.2_Nonsense_Mutation_p.E585*|CUL1_uc003wfa.2_Nonsense_Mutation_p.E356*	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	695					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			ACAGAAGCAGGAACAAGAAAC	0.418													14	72					1.15088e-07	1.19982e-07	1	0	T	148495716	T	T	148495716	4	4	8	1	0	0	0	0	0	1	0	0	4071	1175	41	2	2157	2	CUL1	7	148495716	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8042606	148495716	10642947	247	2136											
ZNF425	155054	broad.mit.edu	37	chr7	148801943	148801943	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	accttcatgcccctcttcagGcggaagcaccggtcacactg	8	8	9	16	2	4	0	3	0	1	0	4	1	4	1	4	3	2	1	4	3	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:148801943G>A	uc003wfj.2	-	4	1093	c.1020C>T	c.(1018-1020)CGC>CGT	p.R340R		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	340	C2H2-type 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CCCTCTTCAGGCGGAAGCACC	0.662													9	38					0	0	0	0	A	148801943	A	A	148801943	2	1	8	1	0	0	0	0	0	0	0	1	17966	1190	42	4		4	ZNF425	7	148801943	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	306227	148801943	10336720	248	2137											
GIMAP6	474344	broad.mit.edu	37	chr7	150327212	150327212	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attctcctggggaatttgttCatattcttcttcctccatct	6	19	5	11	0	5	0	1	0	4	0	8	1	7	1	3	2	0	1	3	2	2	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:150327212C>G	uc003whn.2	-	2	443	c.19G>C	c.(19-21)GAA>CAA	p.E7Q	GIMAP6_uc003whm.2_Missense_Mutation_p.M1I	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	7							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAATTTGTTCATATTCTTCT	0.428													3	89					0	0	0	0	G	150327212	G	G	150327212	3	3	8	1	0	0	0	0	1	0	0	0	6420	835	29	2	867	2	GIMAP6	7	150327212	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1525269	150327212	8811451	249	2138											
RNF32	140545	broad.mit.edu	37	chr7	156437207	156437207	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttagggtcactcatctaaGaaagataacttggcagtcaa	14	12	8	7	0	4	2	3	0	1	2	4	2	4	2	0	2	1	1	0	2	5	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:156437207G>C	uc003wmo.2	+	3	212	c.30G>C	c.(28-30)AAG>AAC	p.K10N	RNF32_uc010lql.1_RNA|RNF32_uc010lqm.2_Missense_Mutation_p.K10N|RNF32_uc003wmp.2_Missense_Mutation_p.K10N|RNF32_uc003wmq.2_Missense_Mutation_p.K10N|RNF32_uc003wmr.2_Missense_Mutation_p.K10N|RNF32_uc003wms.2_Missense_Mutation_p.K10N|RNF32_uc003wmu.2_RNA|RNF32_uc003wmt.2_Missense_Mutation_p.K10N	NM_030936	NP_112198	Q9H0A6	RNF32_HUMAN	ring finger protein 32	10						aggresome|endosome	protein binding|zinc ion binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		ACTCATCTAAGAAAGATAACT	0.333													5	53					0	0	0	0	C	156437207	C	C	156437207	3	2	8	1	0	0	0	0	1	0	0	0	13553	933	33	2	36	2	RNF32	7	156437207	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	6109995	156437207	2701456	250	2139											
CSMD1	64478	broad.mit.edu	37	chr8	2823375	2823375	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgtgactgcttccatgaCatagcctgggttacactgat	9	12	11	9	0	0	3	0	3	0	0	1	4	1	4	2	2	3	2	2	2	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:2823375C>A	uc011kwk.1	-	59	9595	c.9205G>T	c.(9205-9207)GTC>TTC	p.V3069F	CSMD1_uc011kwj.1_Missense_Mutation_p.V2398F|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3069	Extracellular (Potential).|Sushi 24.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCTTCCATGACATAGCCTGGG	0.493													9	6					2.17888e-05	2.23547e-05	1	0	A	2823375	A	A	2823375	3	1	8	1	0	0	0	0	1	0	0	0	3961	478	17	4	1540	4	CSMD1	8	2823375	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		2823375	143540647	251	2140											
SOX7	83595	broad.mit.edu	37	chr8	10583925	10583925	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagtgccgggggagtactCacccctgtcctccttctccc	4	9	11	17	1	2	0	1	0	1	0	5	1	4	1	6	3	2	2	6	3	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:10583925C>G	uc003wtf.2	-	2	569	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	SOX7_uc011kwz.1_Missense_Mutation_p.E216Q|uc003wtg.1_5'Flank	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	164					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GGGGAGTACTCACCCCTGTCC	0.726													8	15					0	0	0	0	G	10583925	G	G	10583925	3	3	8	1	0	0	0	0	1	0	0	0	15020	835	29	2	680	2	SOX7	8	10583925	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7760550	10583925	135780097	252	2141											
CSGALNACT1	55790	broad.mit.edu	37	chr8	19297418	19297418	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acaacagtgagatggactctCccatcctgctcaatgcacat	12	9	7	13	0	2	1	1	1	1	1	4	3	3	2	2	1	3	2	2	1	2	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:19297418C>T	uc011kyn.1	-	6	1940	c.876G>A	c.(874-876)GGG>GGA	p.G292G	CSGALNACT1_uc011kyo.1_Silent_p.G292G|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Silent_p.G291G|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	292	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		GATGGACTCTCCCATCCTGCT	0.418													17	36					0	0	0	0	T	19297418	T	T	19297418	2	4	8	1	0	0	0	0	0	0	0	1	3955	842	30	2		2	CSGALNACT1	8	19297418	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	8713493	19297418	127066604	253	2142											
FAM160B2	64760	broad.mit.edu	37	chr8	21960135	21960135	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgacgggccaggctcctgggGagcagtgagtaccaagggtg	8	6	18	9	1	0	2	0	2	0	0	1	3	1	3	3	5	2	3	3	5	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:21960135G>A	uc011kyx.1	+	16	2140	c.2089G>A	c.(2089-2091)GAG>AAG	p.E697K	FAM160B2_uc011kyy.1_RNA	NM_022749	NP_073586	Q86V87	F16B2_HUMAN	retinoic acid induced 16	697											0						GGCTCCTGGGGAGCAGTGAGT	0.622													5	4					0	0	0	0	A	21960135	A	A	21960135	3	1	8	1	0	0	0	0	1	0	0	0	5499	1175	41	2	1950	2	FAM160B2	8	21960135	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2662717	21960135	124403887	254	2143											
ADAM7	8756	broad.mit.edu	37	chr8	24356805	24356805	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtctatatctcaaccaattgCccctctcagtgcaatgaaaa	13	11	5	12	0	3	1	2	1	3	0	5	1	3	1	3	0	3	1	3	0	7	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:24356805C>T	uc003xeb.2	+	17	2012	c.1899C>T	c.(1897-1899)TGC>TGT	p.C633C	ADAM7_uc003xec.2_Silent_p.C405C	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	633	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		CAACCAATTGCCCCTCTCAGT	0.328													3	46					0	0	0	0	T	24356805	T	T	24356805	2	4	8	1	0	0	0	0	0	0	0	1	251	747	26	4		4	ADAM7	8	24356805	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2396670	24356805	122007217	255	2144											
EBF2	64641	broad.mit.edu	37	chr8	25708194	25708194	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggggcaaaggcactcttctGtttgacagcaggaaaaactg	13	8	12	8	0	2	1	0	1	2	0	2	2	2	2	0	4	2	4	0	4	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:25708194G>C	uc003xes.1	-	15	1629	c.1612C>G	c.(1612-1614)CAG>GAG	p.Q538E	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	538					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GCACTCTTCTGTTTGACAGCA	0.522													41	70					0	0	0	0	C	25708194	C	C	25708194	3	2	8	1	0	0	0	0	1	0	0	0	4903	1386	48	4	123	4	EBF2	8	25708194	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1351389	25708194	120655828	256	2145											
UBXN8	7993	broad.mit.edu	37	chr8	30608921	30608921	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttcctttatcaggaatcaagGattttcttttgctttgtggc	7	19	8	7	0	3	0	2	0	1	0	4	2	4	2	1	3	1	1	1	3	3	8			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:30608921G>A	uc003xii.2	+	2	114	c.97G>A	c.(97-99)GAT>AAT	p.D33N	UBXN8_uc010lvi.2_Intron|UBXN8_uc011lbb.1_RNA|UBXN8_uc003xij.2_RNA	NM_005671	NP_005662	O00124	UBXN8_HUMAN	reproduction 8	33					single fertilization						0						AGGAATCAAGGATTTTCTTTT	0.244													3	18					0	0	0	0	A	30608921	A	A	30608921	3	1	8	1	0	0	0	0	1	0	0	0	16987	1174	41	2	103	2	UBXN8	8	30608921	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4900727	30608921	115755101	257	2146											
C8orf41	80185	broad.mit.edu	37	chr8	33369604	33369604	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaacttgaagcagtgaggtGagcacctccctagcaacttc	11	9	10	11	0	0	3	0	3	0	0	2	3	1	3	2	1	5	4	2	1	4	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:33369604G>A	uc003xjl.3	-	1	1053	c.528C>T	c.(526-528)CTC>CTT	p.L176L	C8orf41_uc003xjk.3_Silent_p.L176L|C8orf41_uc010lvv.2_Silent_p.L176L|C8orf41_uc003xjm.3_Silent_p.L176L|C8orf41_uc003xjn.1_Silent_p.L176L	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	176							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		GCAGTGAGGTGAGCACCTCCC	0.493													6	269					0	0	0	0	A	33369604	A	A	33369604	2	1	8	1	0	0	0	0	0	0	0	1	2439	1277	45	2		2	C8orf41	8	33369604	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2760683	33369604	112994418	258	2147											
PRKDC	5591	broad.mit.edu	37	chr8	48719860	48719860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctggaagaggggtaagcttCtcctctattttgctgagaaa	10	13	11	7	0	3	2	0	1	3	2	4	4	3	3	1	3	2	3	1	3	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:48719860C>G	uc003xqi.2	-	70	9642	c.9585G>C	c.(9583-9585)GAG>GAC	p.E3195D	PRKDC_uc003xqj.2_Missense_Mutation_p.E3195D|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3195	KIP-binding.|FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGGTAAGCTTCTCCTCTATTT	0.423								NHEJ					46	127					0	0	0	0	G	48719860	G	G	48719860	3	3	8	1	0	0	0	0	1	0	0	0	12583	912	32	2	2873	2	PRKDC	8	48719860	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	15350256	48719860	97644162	259	2148											
PRKDC	5591	broad.mit.edu	37	chr8	48777319	48777319	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctacttgtgtgacacatGaacccctaagaaaacaagat	15	8	8	10	0	0	4	0	2	0	2	0	4	0	4	3	1	3	0	3	1	6	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:48777319G>T	uc003xqi.2	-	42	5426	c.5369C>A	c.(5368-5370)TCA>TAA	p.S1790*	PRKDC_uc003xqj.2_Nonsense_Mutation_p.S1790*|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1790					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGTGACACATGAACCCCTAAG	0.443								NHEJ					3	14					6.4e-05	6.52855e-05	1	0	T	48777319	T	T	48777319	4	4	8	1	0	0	0	0	0	1	0	0	12583	1294	45	2	7201	2	PRKDC	8	48777319	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	57459	48777319	97586703	260	2149											
MCM4	4173	broad.mit.edu	37	chr8	48883280	48883280	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctcactgcgtacgtaatGaaagaccctgagacaaggca	13	6	11	11	2	1	3	1	2	0	2	1	4	1	3	2	2	2	3	2	2	4	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:48883280G>A	uc003xqk.1	+	12	1739	c.1644G>A	c.(1642-1644)ATG>ATA	p.M548I	MCM4_uc003xql.1_Missense_Mutation_p.M548I|MCM4_uc011ldi.1_Missense_Mutation_p.M535I	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	548	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				CGTACGTAATGAAAGACCCTG	0.552													14	41					0	0	0	0	A	48883280	A	A	48883280	3	1	8	1	0	0	0	0	1	0	0	0	9442	1290	45	2	1686	2	MCM4	8	48883280	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	105961	48883280	97480742	261	2150											
PXDNL	137902	broad.mit.edu	37	chr8	52284541	52284541	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacatcagcctgcacttgctGaatgctgtcaccattgtcac	9	11	8	13	0	3	1	3	1	0	0	3	2	3	1	2	0	4	3	2	0	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:52284541G>A	uc003xqu.3	-	19	3894	c.3793C>T	c.(3793-3795)CAG>TAG	p.Q1265*	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1265					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGCACTTGCTGAATGCTGTCA	0.532													5	26					0	0	0	0	A	52284541	A	A	52284541	4	1	8	1	0	0	0	0	0	1	0	0	12913	1299	45	2	618	2	PXDNL	8	52284541	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3401261	52284541	94079481	262	2151											
MYBL1	4603	broad.mit.edu	37	chr8	67504755	67504755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttattttcttttccttatCaggatcttcatcaatgaagg	9	19	5	8	0	5	1	3	1	2	0	6	2	6	2	1	2	0	0	1	2	4	8			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:67504755C>T	uc003xwj.2	-	8	1194	c.787G>A	c.(787-789)GAT>AAT	p.D263N	MYBL1_uc003xwl.2_Missense_Mutation_p.D263N|MYBL1_uc003xwk.2_Missense_Mutation_p.D263N	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	263	Transcriptional activation domain (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			TTTTCCTTATCAGGATCTTCA	0.284													6	89					0	0	0	0	T	67504755	T	T	67504755	3	4	8	1	0	0	0	0	1	0	0	0	10062	826	29	2	1507	2	MYBL1	8	67504755	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	15220214	67504755	78859267	263	2152											
ARFGEF1	10565	broad.mit.edu	37	chr8	68150972	68150972	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaataaagtgcttatacctCatgccatgaatttcctaaat	16	13	4	8	0	1	1	1	1	0	0	2	1	2	1	3	0	3	1	3	0	9	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:68150972C>T	uc003xxo.1	-	21	3526	c.3136G>A	c.(3136-3138)GAG>AAG	p.E1046K	ARFGEF1_uc003xxl.1_Missense_Mutation_p.E500K|ARFGEF1_uc003xxn.1_Missense_Mutation_p.E29K	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1046					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GCTTATACCTCATGCCATGAA	0.323													24	76					0	0	0	0	T	68150972	T	T	68150972	3	4	8	1	0	0	0	0	1	0	0	0	852	835	29	2	2489	2	ARFGEF1	8	68150972	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	646217	68150972	78213050	264	2153											
ARFGEF1	10565	broad.mit.edu	37	chr8	68165736	68165736	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcttttgtttctttcattGatatctttttcccagctatt	5	24	4	8	0	4	1	1	1	3	0	5	1	5	1	1	0	1	3	1	0	2	11			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:68165736G>A	uc003xxo.1	-	18	3038	c.2648C>T	c.(2647-2649)TCA>TTA	p.S883L	ARFGEF1_uc003xxl.1_Missense_Mutation_p.S337L	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	883					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TTCTTTCATTGATATCTTTTT	0.308													6	62					0	0	0	0	A	68165736	A	A	68165736	3	1	8	1	0	0	0	0	1	0	0	0	852	1294	45	2	2989	2	ARFGEF1	8	68165736	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	14764	68165736	78198286	265	2154											
TERF1	7013	broad.mit.edu	37	chr8	73942628	73942628	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagggtacagtatccttattGaggtgaagtaaattgacgtt	12	13	12	4	1	0	3	0	3	0	0	1	4	1	3	1	2	1	4	1	2	6	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:73942628G>A	uc003xzd.2	+	7	970	c.945G>A	c.(943-945)TTG>TTA	p.L315L	TERF1_uc003xze.2_Intron	NM_017489	NP_059523	P54274	TERF1_HUMAN	telomeric repeat binding factor 1 isoform 1	315	Interaction with RLIM.				age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			ovary(1)|lung(1)|skin(1)	3	Breast(64;0.218)		Epithelial(68;0.0984)			TATCCTTATTGAGGTGAAGTA	0.318													6	28					0	0	0	0	A	73942628	A	A	73942628	2	1	8	1	0	0	0	0	0	0	0	1	15827	1281	45	2		2	TERF1	8	73942628	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5776892	73942628	72421394	266	2155											
TCEB1	6921	broad.mit.edu	37	chr8	74859029	74859029	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatctctctaaaattgacctCattggtttcgttctcagcaa	10	16	5	10	1	4	1	2	1	3	0	7	1	4	1	1	1	1	3	1	1	4	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:74859029C>T	uc003xzx.1	-	4	260	c.175G>A	c.(175-177)GAG>AAG	p.E59K	TCEB1_uc003xzy.1_Missense_Mutation_p.E59K|TCEB1_uc003xzz.1_Missense_Mutation_p.E43K|TCEB1_uc003yaa.1_Missense_Mutation_p.E59K	NM_005648	NP_005639	Q15369	ELOC_HUMAN	elongin C	59					interspecies interaction between organisms|positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm	protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0136)|all cancers(69;0.0431)|BRCA - Breast invasive adenocarcinoma(89;0.0499)			AAATTGACCTCATTGGTTTCG	0.289													18	55					0	0	0	0	T	74859029	T	T	74859029	3	4	8	1	0	0	0	0	1	0	0	0	15745	835	29	2	167	2	TCEB1	8	74859029	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	916401	74859029	71504993	267	2156											
JPH1	56704	broad.mit.edu	37	chr8	75227373	75227373	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgaagccgttgcgcttgtCgttcttccactcgcccatgt	4	12	10	15	5	1	0	0	0	1	0	4	1	2	0	4	0	2	3	4	0	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:75227373C>T	uc003yae.2	-	2	902	c.862G>A	c.(862-864)GAC>AAC	p.D288N	JPH1_uc003yaf.2_Missense_Mutation_p.D288N|JPH1_uc003yag.1_Missense_Mutation_p.D152N	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	288	Cytoplasmic (Potential).|MORN 6.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			TTGCGCTTGTCGTTCTTCCAC	0.542													50	122					0	0	0	0	T	75227373	T	T	75227373	3	4	8	1	0	0	0	0	1	0	0	0	7999	884	31	1	1139	1	JPH1	8	75227373	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	368344	75227373	71136649	268	2157											
ZFHX4	79776	broad.mit.edu	37	chr8	77617904	77617904	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtacctcgtcctcctcggcGactgtttctgatgacacaga	7	11	10	13	3	1	3	0	2	1	1	5	4	3	3	3	2	1	2	3	2	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:77617904G>A	uc003yav.2	+	2	1968	c.1581G>A	c.(1579-1581)GCG>GCA	p.A527A	ZFHX4_uc003yat.1_Silent_p.A527A|ZFHX4_uc003yau.1_Silent_p.A527A|ZFHX4_uc003yaw.1_Silent_p.A527A	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	527						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCTCCTCGGCGACTGTTTCTG	0.433										HNSCC(33;0.089)			14	57					0	0	0	0	A	77617904	A	A	77617904	2	1	8	1	0	0	0	0	0	0	0	1	17702	1045	37	1		1	ZFHX4	8	77617904	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2390531	77617904	68746118	269	2158											
TPD52	7163	broad.mit.edu	37	chr8	80976724	80976724	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttctttacctttgcaagttCtcttcttagctcttcctgct	4	20	5	12	0	4	0	0	0	4	0	6	0	5	0	2	0	4	5	2	0	3	8			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:80976724C>G	uc003ybr.1	-	2	566	c.244G>C	c.(244-246)GAA>CAA	p.E82Q	TPD52_uc010lzr.2_RNA|TPD52_uc010lzs.1_RNA|TPD52_uc003ybs.1_Missense_Mutation_p.E42Q|TPD52_uc003ybt.1_Missense_Mutation_p.E42Q|TPD52_uc003ybq.1_RNA|TPD52_uc003ybu.1_RNA	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	82	Potential.				anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			TTTGCAAGTTCTCTTCTTAGC	0.428													43	105					0	0	0	0	G	80976724	G	G	80976724	3	3	8	1	0	0	0	0	1	0	0	0	16464	922	32	2	527	2	TPD52	8	80976724	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3358820	80976724	65387298	270	2159											
RBM12B	389677	broad.mit.edu	37	chr8	94746326	94746326	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctccgggggcgggcgcctGaaatgctctgggggtggccg	3	7	20	11	4	1	1	0	1	1	0	2	1	2	1	3	6	2	2	3	6	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:94746326G>A	uc003yfz.2	-	3	2506	c.2313C>T	c.(2311-2313)TTC>TTT	p.F771F		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	771							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GCGGGCGCCTGAAATGCTCTG	0.662													25	88					0	0	0	0	A	94746326	A	A	94746326	2	1	8	1	0	0	0	0	0	0	0	1	13179	1281	45	2		2	RBM12B	8	94746326	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	13769602	94746326	51617696	271	2160											
ESRP1	54845	broad.mit.edu	37	chr8	95690463	95690463	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctcctacacatttccagctCctgctgcagttattcctaca	8	13	4	16	0	0	0	0	0	0	0	4	0	4	0	5	0	5	4	5	0	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:95690463C>T	uc003ygq.3	+	13	1867	c.1684C>T	c.(1684-1686)CCT>TCT	p.P562S	ESRP1_uc003ygr.3_Missense_Mutation_p.P558S|ESRP1_uc003ygs.3_Missense_Mutation_p.P558S|ESRP1_uc003ygt.3_Missense_Mutation_p.P562S|ESRP1_uc003ygu.3_Missense_Mutation_p.P558S|ESRP1_uc003ygv.2_Missense_Mutation_p.P402S|ESRP1_uc003ygw.2_Missense_Mutation_p.P402S	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	562					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						ATTTCCAGCTCCTGCTGCAGT	0.493													24	81					0	0	0	0	T	95690463	T	T	95690463	3	4	8	1	0	0	0	0	1	0	0	0	5282	855	30	2	1734	2	ESRP1	8	95690463	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	944137	95690463	50673559	272	2161											
NIPAL2	79815	broad.mit.edu	37	chr8	99215352	99215352	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacctgcaatgatggcactGattgtaaagaaaatatgatt	15	12	8	6	0	1	4	1	3	0	1	1	4	1	4	1	1	1	3	1	1	6	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:99215352G>C	uc003yil.1	-	8	1120	c.864C>G	c.(862-864)ATC>ATG	p.I288M	NIPAL2_uc011lgw.1_Missense_Mutation_p.I84M|NIPAL2_uc003yim.1_Missense_Mutation_p.I288M	NM_024759	NP_079035	Q9H841	NPAL2_HUMAN	NIPA-like domain containing 2	288	Helical; (Potential).					integral to membrane					0						TGATGGCACTGATTGTAAAGA	0.398													23	38					0	0	0	0	C	99215352	C	C	99215352	3	2	8	1	0	0	0	0	1	0	0	0	10479	1280	45	2	262	2	NIPAL2	8	99215352	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3524889	99215352	47148670	273	2162											
VPS13B	157680	broad.mit.edu	37	chr8	100654378	100654378	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagttcattaaatctcccaGaagttgattcagatgttgct	12	14	8	7	0	3	4	2	1	1	3	4	4	3	4	1	0	1	4	1	0	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:100654378G>A	uc003yiv.2	+	34	5746	c.5635G>A	c.(5635-5637)GAA>AAA	p.E1879K	VPS13B_uc003yiw.2_Missense_Mutation_p.E1854K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1879					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAATCTCCCAGAAGTTGATTC	0.388													20	189					0	0	0	0	A	100654378	A	A	100654378	3	1	8	1	0	0	0	0	1	0	0	0	17258	943	33	2	5959	2	VPS13B	8	100654378	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1439026	100654378	45709644	274	2163											
VPS13B	157680	broad.mit.edu	37	chr8	100844830	100844830	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaccagagtttcccagacaGagtgtggcagtacccctcgg	10	7	12	12	1	0	4	0	0	0	4	2	4	1	4	4	2	1	3	4	2	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:100844830G>C	uc003yiv.2	+	52	9750	c.9639G>C	c.(9637-9639)CAG>CAC	p.Q3213H	VPS13B_uc003yiw.2_Missense_Mutation_p.Q3188H	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3213					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTCCCAGACAGAGTGTGGCAG	0.473													23	104					0	0	0	0	C	100844830	C	C	100844830	3	2	8	1	0	0	0	0	1	0	0	0	17258	933	33	2	10035	2	VPS13B	8	100844830	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	190452	100844830	45519192	275	2164											
YWHAZ	7534	broad.mit.edu	37	chr8	101936232	101936232	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttagcgtgctgtctttgtatGactcttcacttaatgtatca	8	18	7	8	1	4	1	2	1	2	0	4	1	4	1	0	0	2	3	0	0	4	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:101936232G>A	uc011lhe.1	-	5	806	c.629C>T	c.(628-630)TCA>TTA	p.S210L	YWHAZ_uc003yjv.2_Missense_Mutation_p.S210L|YWHAZ_uc011lhf.1_Missense_Mutation_p.S210L|YWHAZ_uc003yjw.2_Missense_Mutation_p.S210L|YWHAZ_uc010mbq.2_Missense_Mutation_p.S133L|YWHAZ_uc011lhg.1_Missense_Mutation_p.S90L|YWHAZ_uc010mbr.2_Missense_Mutation_p.S210L|YWHAZ_uc003yjx.2_Missense_Mutation_p.S210L|YWHAZ_uc003yjy.2_Missense_Mutation_p.S210L	NM_001135702	NP_001129174	P63104	1433Z_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	210					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	GTCTTTGTATGACTCTTCACT	0.343													42	159					0	0	0	0	A	101936232	A	A	101936232	3	1	8	1	0	0	0	0	1	0	0	0	17574	1294	45	2	116	2	YWHAZ	8	101936232	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1091402	101936232	44427790	276	2165											
NCALD	83988	broad.mit.edu	37	chr8	102701558	102701558	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagaactggccggcactgctCgggtcgcactgcaggaggcg	7	5	16	13	4	0	1	0	0	0	1	2	2	0	2	1	5	3	4	1	5	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:102701558C>T	uc003yke.2	-	4	930	c.561G>A	c.(559-561)CCG>CCA	p.P187P	NCALD_uc003ykf.2_Silent_p.P187P|NCALD_uc003ykg.2_Silent_p.P187P|NCALD_uc003ykh.2_Silent_p.P187P|NCALD_uc003yki.2_Silent_p.P187P|NCALD_uc003ykj.2_Silent_p.P187P|NCALD_uc003ykk.2_Silent_p.P187P|NCALD_uc003ykl.2_Silent_p.P187P	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	187					synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			CGGCACTGCTCGGGTCGCACT	0.502													5	27					0	0	0	0	T	102701558	T	T	102701558	2	4	8	1	0	0	0	0	0	0	0	1	10255	871	31	1		1	NCALD	8	102701558	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	765326	102701558	43662464	277	2166											
TNFRSF11B	4982	broad.mit.edu	37	chr8	119940992	119940992	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attacctattccacatttttGagttgattcactgtttccgg	8	18	6	9	1	1	2	1	2	0	0	3	2	3	2	3	1	1	2	3	1	2	8			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:119940992G>C	uc003yon.3	-	3	900	c.577C>G	c.(577-579)CAA>GAA	p.Q193E	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	193					apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			CCACATTTTTGAGTTGATTCA	0.393													4	200					0	0	0	0	C	119940992	C	C	119940992	3	2	8	1	0	0	0	0	1	0	0	0	16351	1299	45	2	640	2	TNFRSF11B	8	119940992	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	17239434	119940992	26423030	278	2167											
COL14A1	7373	broad.mit.edu	37	chr8	121180418	121180418	+	Frame_Shift_Del	DEL	G	-	-																															agttaaagatttagaaaaaaGaaaggatccaaagcccagag																										TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:121180418delG	uc003yox.2	+	5	633	c.368delG	c.(367-369)AGAfs	p.R123fs		NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	123					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TTAGAAAAAAGAAAGGATCCA	0.353													---	---	---								-	121180418	-	-	121180418	7	5	8	1	0	1	0	1	0	0	0	0	3686	942	33	0	382	0	COL14A1	8	121180418	Frame_Shift_Del	DEL	G	TCGA-BA-5152-01A-02D-1870-08	1239426	121180418	25183604	279	2168											
SNTB1	6641	broad.mit.edu	37	chr8	121823639	121823639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtacagggcttgggtctggtCcgccgccagccccttgaaga	6	8	14	13	2	1	2	0	1	1	1	2	2	2	2	5	3	2	2	5	3	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:121823639C>T	uc010mdg.2	-	1	671	c.445G>A	c.(445-447)GAC>AAC	p.D149N	SNTB1_uc003ype.2_Missense_Mutation_p.D149N	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	149	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			TGGGTCTGGTCCGCCGCCAGC	0.657													22	88					0	0	0	0	T	121823639	T	T	121823639	3	4	8	1	0	0	0	0	1	0	0	0	14936	855	30	2	1199	2	SNTB1	8	121823639	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	643221	121823639	24540383	280	2169											
WDR67	93594	broad.mit.edu	37	chr8	124140671	124140671	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagtatccagtatttaatCaatatccaaagtttattgtg	13	15	7	6	0	1	0	1	0	0	0	3	0	3	0	2	1	0	4	2	1	7	8			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:124140671C>A	uc003ypp.1	+	14	2125	c.2035C>A	c.(2035-2037)CAA>AAA	p.Q679K	WDR67_uc011lig.1_Missense_Mutation_p.Q679K|WDR67_uc011lih.1_Missense_Mutation_p.Q569K|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Intron|WDR67_uc003ypt.1_Missense_Mutation_p.Q136K|WDR67_uc003ypu.1_Missense_Mutation_p.Q136K	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	679						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			AGTATTTAATCAATATCCAAA	0.358													36	63					1.836e-18	1.96596e-18	1	0	A	124140671	A	A	124140671	3	1	8	1	0	0	0	0	1	0	0	0	17386	827	29	2	2089	2	WDR67	8	124140671	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2317032	124140671	22223351	281	2170											
KLHL38	340359	broad.mit.edu	37	chr8	124664436	124664436	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgatctggcatgcaggcgagGactgcaggagggcatcgttg	8	8	17	8	2	1	1	0	1	1	0	2	4	1	3	0	5	2	5	0	5	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:124664436G>A	uc003yqs.1	-	1	755	c.731C>T	c.(730-732)TCC>TTC	p.S244F		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	244											0						TGCAGGCGAGGACTGCAGGAG	0.552													19	80					0	0	0	0	A	124664436	A	A	124664436	3	1	8	1	0	0	0	0	1	0	0	0	8429	1174	41	2	1026	2	KLHL38	8	124664436	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	523765	124664436	21699586	282	2171											
FER1L6	654463	broad.mit.edu	37	chr8	125072457	125072457	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcaaggcctcccacccgttGagccaccagacatcacccag	10	5	8	18	1	1	2	1	1	0	1	2	2	2	2	6	1	2	2	6	1	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:125072457G>C	uc003yqw.2	+	23	3117	c.2911G>C	c.(2911-2913)GAG>CAG	p.E971Q	uc003yqy.1_RNA	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	971	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCCACCCGTTGAGCCACCAGA	0.582													41	119					0	0	0	0	C	125072457	C	C	125072457	3	2	8	1	0	0	0	0	1	0	0	0	5847	1291	45	2	2997	2	FER1L6	8	125072457	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	408021	125072457	21291565	283	2172											
TMEM71	137835	broad.mit.edu	37	chr8	133740154	133740154	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagatatgatgtggctggaaGaggaggtgatcacagactct	12	9	15	5	0	2	5	1	2	1	3	2	8	2	7	0	4	0	1	0	4	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:133740154G>A	uc003ytp.2	-	6	792	c.563C>T	c.(562-564)TCT>TTT	p.S188F	TMEM71_uc003ytm.1_Missense_Mutation_p.S10F|TMEM71_uc003ytn.2_Missense_Mutation_p.S170F|TMEM71_uc003yto.2_Intron	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	189						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GTGGCTGGAAGAGGAGGTGAT	0.473													16	144					0	0	0	0	A	133740154	A	A	133740154	3	1	8	1	0	0	0	0	1	0	0	0	16266	942	33	2	341	2	TMEM71	8	133740154	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8667697	133740154	12623868	284	2173											
CYP11B2	1585	broad.mit.edu	37	chr8	143993975	143993975	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcagcagcatctctgcctCtgccaggcgccgcccgaggc	6	5	12	18	3	2	0	0	0	2	0	3	1	2	0	4	2	5	3	4	2	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:143993975C>G	uc003yxk.1	-	8	1372	c.1369G>C	c.(1369-1371)GAG>CAG	p.E457Q		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	457					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	ATCTCTGCCTCTGCCAGGCGC	0.692									Familial_Hyperaldosteronism_type_I				15	69					0	0	0	0	G	143993975	G	G	143993975	3	3	8	1	0	0	0	0	1	0	0	0	4163	922	32	2	150	2	CYP11B2	8	143993975	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	10253821	143993975	2370047	285	2174											
ZNF623	9831	broad.mit.edu	37	chr8	144732148	144732148	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcacataggacgacgtcaGacagactcacggtgatggag	13	6	12	10	3	3	3	3	1	0	2	3	6	3	5	0	3	0	0	0	3	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:144732148G>A	uc003yzd.2	+	1	195	c.106G>A	c.(106-108)GAC>AAC	p.D36N	ZNF623_uc011lkp.1_5'UTR|ZNF623_uc003yzc.2_5'UTR	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	36					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GACGACGTCAGACAGACTCAC	0.502													41	74					0	0	0	0	A	144732148	A	A	144732148	3	1	8	1	0	0	0	0	1	0	0	0	18114	942	33	2	108	2	ZNF623	8	144732148	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	738173	144732148	1631874	286	2175											
EPPK1	83481	broad.mit.edu	37	chr8	144941431	144941431	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgcctccgccttctcgatGagctgcttctgcatggcctg	4	12	11	14	2	2	1	0	1	2	0	4	2	3	1	4	1	4	3	4	1	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:144941431G>A	uc003zaa.1	-	1	6004	c.5991C>T	c.(5989-5991)CTC>CTT	p.L1997L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1997	Plectin 33.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTTCTCGATGAGCTGCTTCT	0.647													11	30					0	0	0	0	A	144941431	A	A	144941431	2	1	8	1	0	0	0	0	0	0	0	1	5214	1277	45	2		2	EPPK1	8	144941431	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	209283	144941431	1422591	287	2176											
ZNF16	7564	broad.mit.edu	37	chr8	146157135	146157135	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcactgcacacatacggtttCtccccagaatggattctttg	9	13	7	12	1	3	1	1	0	2	1	4	2	3	2	2	2	2	2	2	2	2	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:146157135C>T	uc003zet.2	-	4	1225	c.1038G>A	c.(1036-1038)GAG>GAA	p.E346E	ZNF16_uc003zeu.2_Silent_p.E346E	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		CATACGGTTTCTCCCCAGAAT	0.488													15	81					0	0	0	0	T	146157135	T	T	146157135	2	4	8	1	0	0	0	0	0	0	0	1	17805	912	32	2		2	ZNF16	8	146157135	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1215704	146157135	206887	288	2177											
C9orf68	55064	broad.mit.edu	37	chr9	4605410	4605410	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cataccctctcatggatattCttccatgtggactgagaacc	10	12	7	12	0	2	1	1	1	2	1	4	4	3	3	3	2	2	0	3	2	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:4605410C>T	uc011llz.1	-	9	1090	c.852G>A	c.(850-852)AAG>AAA	p.K284K	C9orf68_uc003zik.2_RNA|C9orf68_uc003zil.2_RNA|C9orf68_uc010mhj.2_Silent_p.K342K|C9orf68_uc011lly.1_Silent_p.K219K	NM_001039395	NP_001034484	B4DIY4	B4DIY4_HUMAN	hypothetical protein LOC55064	284											0		Breast(48;0.0456)		GBM - Glioblastoma multiforme(50;0.0222)		CATGGATATTCTTCCATGTGG	0.343													20	79					0	0	0	0	T	4605410	T	T	4605410	2	4	8	1	0	0	0	0	0	0	0	1	2503	912	32	2		2	C9orf68	9	4605410	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08		4605410	136608021	289	2178											
CNTLN	54875	broad.mit.edu	37	chr9	17143343	17143343	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaggttacaaacccagatCtcacacaagtggtcagtttg	12	10	8	11	0	2	1	2	0	1	1	4	1	3	1	2	2	2	2	2	2	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:17143343C>G	uc003zmz.2	+	2	444	c.418C>G	c.(418-420)CTC>GTC	p.L140V	CNTLN_uc003zmx.3_Missense_Mutation_p.L140V|CNTLN_uc003zmy.2_Missense_Mutation_p.L140V|CNTLN_uc003zmw.1_Missense_Mutation_p.L140V	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	140						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		AAACCCAGATCTCACACAAGT	0.348													5	178					0	0	0	0	G	17143343	G	G	17143343	3	3	8	1	0	0	0	0	1	0	0	0	3654	913	32	2	424	2	CNTLN	9	17143343	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	12537933	17143343	124070088	290	2179											
KIF24	347240	broad.mit.edu	37	chr9	34290296	34290296	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagatatctttggcagctaGagcatacaatcctgggttct	11	12	10	8	0	2	2	0	0	2	2	3	3	3	2	1	2	3	4	1	2	5	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:34290296G>A	uc003zua.3	-	5	1123	c.1003C>T	c.(1003-1005)CTA>TTA	p.L335L	KIF24_uc010mkb.2_Silent_p.L366L	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	335	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			TTGGCAGCTAGAGCATACAAT	0.458													60	51					0	0	0	0	A	34290296	A	A	34290296	2	1	8	1	0	0	0	0	0	0	0	1	8331	933	33	2		2	KIF24	9	34290296	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	17146953	34290296	106923135	291	2180											
KIF27	55582	broad.mit.edu	37	chr9	86518637	86518637	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcaatccactattgatttGaatggattctttgaaccgtt	11	15	7	8	1	1	3	0	3	1	0	2	4	2	4	2	1	2	2	2	1	4	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:86518637G>C	uc004ana.2	-	4	940	c.796C>G	c.(796-798)CAA>GAA	p.Q266E	KIF27_uc010mpw.2_Missense_Mutation_p.Q266E|KIF27_uc010mpx.2_Missense_Mutation_p.Q266E	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	266	Kinesin-motor.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						CTATTGATTTGAATGGATTCT	0.428													30	81					0	0	0	0	C	86518637	C	C	86518637	3	2	8	1	0	0	0	0	1	0	0	0	8335	1299	45	2	3469	2	KIF27	9	86518637	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	52228341	86518637	54694794	292	2181											
NTRK2	4915	broad.mit.edu	37	chr9	87482318	87482318	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatccccagtactttggcatCaccaacagtcagctcaagcc	12	8	6	15	0	3	0	3	0	0	0	4	0	4	0	4	1	4	3	4	1	4	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:87482318C>T	uc004aoa.1	+	15	2495	c.1557C>T	c.(1555-1557)ATC>ATT	p.I519I	NTRK2_uc004any.1_Silent_p.I519I|NTRK2_uc004anz.1_Silent_p.I535I|NTRK2_uc011lsz.1_Silent_p.I535I|NTRK2_uc011lta.1_Silent_p.I519I|NTRK2_uc004aoc.2_Silent_p.I70I	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	519	Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						ACTTTGGCATCACCAACAGTC	0.453										TSP Lung(25;0.17)			35	93					0	0	0	0	T	87482318	T	T	87482318	2	4	8	1	0	0	0	0	0	0	0	1	10761	816	29	2		2	NTRK2	9	87482318	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	963681	87482318	53731113	293	2182											
NOL8	55035	broad.mit.edu	37	chr9	95077643	95077643	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtagtttaatacagtgatCagaaagctcacagttttctc	12	15	7	7	0	3	2	2	1	1	1	4	2	3	2	0	0	2	4	0	0	4	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:95077643C>T	uc004arv.2	-	7	1601	c.1264G>A	c.(1264-1266)GAT>AAT	p.D422N	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.D354N	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	422					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						ATACAGTGATCAGAAAGCTCA	0.333													7	30					0	0	0	0	T	95077643	T	T	95077643	3	4	8	1	0	0	0	0	1	0	0	0	10581	826	29	2	2283	2	NOL8	9	95077643	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7595325	95077643	46135788	294	2183											
NOL8	55035	broad.mit.edu	37	chr9	95077919	95077919	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttcaaaaggatcactttCagattcatttattgagggtt	13	15	7	6	0	4	2	4	1	0	1	4	3	4	3	0	2	1	1	0	2	4	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:95077919C>T	uc004arv.2	-	7	1325	c.988G>A	c.(988-990)GAA>AAA	p.E330K	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.E262K	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	330					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						GGATCACTTTCAGATTCATTT	0.353													21	35					0	0	0	0	T	95077919	T	T	95077919	3	4	8	1	0	0	0	0	1	0	0	0	10581	835	29	2	2559	2	NOL8	9	95077919	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	276	95077919	46135512	295	2184											
ZNF484	83744	broad.mit.edu	37	chr9	95610741	95610741	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctaaaatggaatatgggtCatctcttgtgaagagattaa	14	14	9	4	0	3	2	1	1	2	1	4	4	3	3	0	2	0	0	0	2	6	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:95610741C>T	uc004asu.1	-	5	477	c.328G>A	c.(328-330)GAC>AAC	p.D110N	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Missense_Mutation_p.D112N|ZNF484_uc010mrb.1_Missense_Mutation_p.D74N|ZNF484_uc004asv.1_Missense_Mutation_p.D74N	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	110					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAATATGGGTCATCTCTTGTG	0.353													39	110					0	0	0	0	T	95610741	T	T	95610741	3	4	8	1	0	0	0	0	1	0	0	0	18004	826	29	2	2234	2	ZNF484	9	95610741	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	532822	95610741	45602690	296	2185											
GABBR2	9568	broad.mit.edu	37	chr9	101304180	101304180	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacctctgaacgtcttgcGtcagcgtgcccacgcgcttc	7	9	10	15	5	3	2	1	1	2	1	4	2	3	2	2	0	5	1	2	0	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:101304180G>A	uc004ays.2	-	3	761	c.605C>T	c.(604-606)ACG>ATG	p.T202M		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	202	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	AACGTCTTGCGTCAGCGTGCC	0.532													9	48					0	0	0	0	A	101304180	A	A	101304180	3	1	8	1	0	0	0	0	1	0	0	0	6190	1145	40	1	2288	1	GABBR2	9	101304180	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5693439	101304180	39909251	297	2186											
GALNT12	79695	broad.mit.edu	37	chr9	101608279	101608279	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttttcgagtacacgtcccaGaaagaaatacgctataacac	15	10	6	10	3	0	2	0	0	0	2	2	3	1	2	1	0	3	2	1	0	6	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:101608279G>C	uc004ayz.2	+	9	1479	c.1479G>C	c.(1477-1479)CAG>CAC	p.Q493H		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	493	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				ACACGTCCCAGAAAGAAATAC	0.483													11	41					0	0	0	0	C	101608279	C	C	101608279	3	2	8	1	0	0	0	0	1	0	0	0	6245	933	33	2	1513	2	GALNT12	9	101608279	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	304099	101608279	39605152	298	2187											
COL15A1	1306	broad.mit.edu	37	chr9	101763192	101763192	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgaccccattactgacagcGgctcaggggctggggccttc	6	8	14	13	1	1	2	1	2	0	0	2	2	1	2	3	5	2	2	3	5	1	2	rs137949756		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:101763192G>C	uc004azb.1	+	7	1230	c.1024G>C	c.(1024-1026)GGC>CGC	p.G342R		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	342	Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding	p.G342S(1)		ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TACTGACAGCGGCTCAGGGGC	0.468											OREG0019364	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	54					0	0	0	0	C	101763192	C	C	101763192	3	2	8	1	0	0	0	0	1	0	0	0	3687	1116	39	3	1050	3	COL15A1	9	101763192	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	154913	101763192	39450239	299	2188											
OR13C3	138803	broad.mit.edu	37	chr9	107298345	107298345	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaagatggtgtagaggatGaacatataggagaaaaaaat	19	8	12	2	0	0	4	0	1	0	3	0	6	0	5	0	3	2	2	0	3	8	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:107298345G>A	uc004bcb.1	-	1	750	c.750C>T	c.(748-750)TTC>TTT	p.F250F		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	250	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TGTAGAGGATGAACATATAGG	0.428													37	81					0	0	0	0	A	107298345	A	A	107298345	2	1	8	1	0	0	0	0	0	0	0	1	10989	1281	45	2		2	OR13C3	9	107298345	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5535153	107298345	33915086	300	2189											
OR13D1	286365	broad.mit.edu	37	chr9	107456838	107456838	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccatgactgaattctttCtggtggggctttcccaatat	7	15	9	10	0	2	2	0	2	2	0	3	2	3	2	2	3	1	1	2	3	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:107456838C>G	uc011lvs.1	+	1	136	c.136C>G	c.(136-138)CTG>GTG	p.L46V		NM_001004484	NP_001004484	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D,	46	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGAATTCTTTCTGGTGGGGCT	0.438													27	69					0	0	0	0	G	107456838	G	G	107456838	3	3	8	1	0	0	0	0	1	0	0	0	10994	912	32	2	138	2	OR13D1	9	107456838	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	158493	107456838	33756593	301	2190											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112899402	112899402	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcagcccccatcgcagctCtgcacagcccctgcctcttc	6	7	7	21	1	2	0	0	0	2	0	4	0	2	0	5	0	6	4	5	0	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:112899402C>G	uc004bei.2	+	9	2466	c.2274C>G	c.(2272-2274)CTC>CTG	p.L758L	PALM2-AKAP2_uc004bek.3_Silent_p.L526L|PALM2-AKAP2_uc004bej.3_Silent_p.L526L|PALM2-AKAP2_uc004bel.1_Silent_p.L336L|AKAP2_uc011lwi.1_Silent_p.L384L|AKAP2_uc004bem.2_Silent_p.L384L|PALM2-AKAP2_uc010mtw.1_Silent_p.L344L|AKAP2_uc011lwj.1_Silent_p.L295L|PALM2-AKAP2_uc004ben.2_Silent_p.L295L	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	295							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						CATCGCAGCTCTGCACAGCCC	0.378													10	22					0	0	0	0	G	112899402	G	G	112899402	2	3	8	1	0	0	0	0	0	0	0	1	11464	900	32	2		2	PALM2-AKAP2	9	112899402	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5442564	112899402	28314029	302	2191											
SUSD1	64420	broad.mit.edu	37	chr9	114875121	114875121	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaggtatcattaaacagtGatacatcattaatctttgtc	14	14	5	8	0	3	1	2	1	1	0	4	1	3	1	0	1	2	1	0	1	5	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:114875121G>C	uc004bfu.2	-	7	955	c.914C>G	c.(913-915)TCA>TGA	p.S305*	SUSD1_uc010mui.2_Nonsense_Mutation_p.S305*|SUSD1_uc010muj.2_Nonsense_Mutation_p.S305*	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	305	Extracellular (Potential).					integral to membrane	calcium ion binding				0						ATTAAACAGTGATACATCATT	0.343													23	52					0	0	0	0	C	114875121	C	C	114875121	4	2	8	1	0	0	0	0	0	1	0	0	15473	1294	45	2	1373	2	SUSD1	9	114875121	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1975719	114875121	26338310	303	2192											
FKBP15	23307	broad.mit.edu	37	chr9	115952852	115952852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caacttggctttgactgcatCgggactctaaaaagagagga	13	9	11	8	1	1	2	0	1	1	1	2	5	1	4	0	3	2	2	0	3	4	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:115952852C>T	uc004bgs.2	-	12	1190	c.1072G>A	c.(1072-1074)GAT>AAT	p.D358N	FKBP15_uc010muu.1_Missense_Mutation_p.D422N|FKBP15_uc011lxc.1_5'Flank|FKBP15_uc011lxd.1_Missense_Mutation_p.D290N|FKBP15_uc010mut.1_Missense_Mutation_p.D226N|FKBP15_uc004bgt.2_Missense_Mutation_p.D358N	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	358					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						TTGACTGCATCGGGACTCTAA	0.458													5	6					0	0	0	0	T	115952852	T	T	115952852	3	4	8	1	0	0	0	0	1	0	0	0	5937	884	31	1	2655	1	FKBP15	9	115952852	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1077731	115952852	25260579	304	2193											
TNC	3371	broad.mit.edu	37	chr9	117848518	117848518	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtccctggggcattggcgatCccggcagtcttcccctgtgt	3	11	13	14	2	1	0	0	0	1	0	4	1	4	0	4	4	0	2	4	4	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:117848518C>T	uc004bjj.3	-	3	1854	c.1492G>A	c.(1492-1494)GAT>AAT	p.D498N	TNC_uc010mvf.2_Missense_Mutation_p.D498N	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	498	EGF-like 12.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						CATTGGCGATCCCGGCAGTCT	0.602													43	140					0	0	0	0	T	117848518	T	T	117848518	3	4	8	1	0	0	0	0	1	0	0	0	16336	855	30	2	5217	2	TNC	9	117848518	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1895666	117848518	23364913	305	2194											
CEP110	11064	broad.mit.edu	37	chr9	123924347	123924347	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaggagaaactggagttaGagaatttgcagcagatatcc	14	11	11	5	0	0	3	0	0	0	3	1	6	1	4	1	2	3	3	1	2	5	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:123924347G>C	uc004bkx.1	+	32	5252	c.5221G>C	c.(5221-5223)GAG>CAG	p.E1741Q	CEP110_uc004blb.1_Missense_Mutation_p.E410Q|CEP110_uc010mvp.1_Intron	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1741	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						ACTGGAGTTAGAGAATTTGCA	0.413													20	70					0	0	0	0	C	123924347	C	C	123924347	3	2	8	1	0	0	0	0	1	0	0	0	3260	943	33	2	5347	2	CEP110	9	123924347	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	6075829	123924347	17289084	306	2195											
TTLL11	158135	broad.mit.edu	37	chr9	124794104	124794104	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggttctcactgctctgctCagagtaattttacgcaccat	9	14	7	11	1	3	1	2	0	2	1	4	1	3	1	1	1	3	5	1	1	2	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:124794104C>T	uc004blt.1	-	3	1049	c.861G>A	c.(859-861)CTG>CTA	p.L287L	TTLL11_uc011lyl.1_Silent_p.L287L|TTLL11_uc004blr.2_Intron|TTLL11_uc011lym.1_Intron|TTLL11_uc004blu.1_Intron	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	287	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						CTGCTCTGCTCAGAGTAATTT	0.478													32	99					0	0	0	0	T	124794104	T	T	124794104	2	4	8	1	0	0	0	0	0	0	0	1	16792	813	29	2		2	TTLL11	9	124794104	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	869757	124794104	16419327	307	2196											
RABEPK	10244	broad.mit.edu	37	chr9	127990317	127990317	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgggggacagattctatgatGacctccactgcattgatata	11	11	10	9	1	1	4	0	3	1	1	2	5	2	5	2	2	1	1	2	2	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:127990317G>A	uc004bpi.2	+	7	828	c.655G>A	c.(655-657)GAC>AAC	p.D219N	RABEPK_uc004bpj.2_Missense_Mutation_p.D168N|RABEPK_uc004bpk.2_Missense_Mutation_p.D219N|RABEPK_uc004bpl.1_Missense_Mutation_p.D168N|RABEPK_uc004bpm.2_Missense_Mutation_p.D219N	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	219	Kelch 4.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						ATTCTATGATGACCTCCACTG	0.403													13	26					0	0	0	0	A	127990317	A	A	127990317	3	1	8	1	0	0	0	0	1	0	0	0	13028	1290	45	2	673	2	RABEPK	9	127990317	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3196213	127990317	13223114	308	2197											
LRSAM1	90678	broad.mit.edu	37	chr9	130263396	130263396	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctggaggtgcaggcctcaGagtgtgtcgtgtgcctggaa	7	9	17	8	1	1	1	1	0	0	1	2	3	1	3	2	4	3	2	2	4	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:130263396G>C	uc004brb.1	+	25	2365	c.2020G>C	c.(2020-2022)GAG>CAG	p.E674Q	LRSAM1_uc010mxk.1_Missense_Mutation_p.E647Q|LRSAM1_uc004brc.1_Missense_Mutation_p.E674Q|LRSAM1_uc004brd.1_Missense_Mutation_p.E674Q|LRSAM1_uc004bre.1_Missense_Mutation_p.E254Q|LRSAM1_uc004brg.1_Missense_Mutation_p.E105Q	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	674					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						GCAGGCCTCAGAGTGTGTCGT	0.662													13	35					0	0	0	0	C	130263396	C	C	130263396	3	2	8	1	0	0	0	0	1	0	0	0	9093	943	33	2	2110	2	LRSAM1	9	130263396	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2273079	130263396	10950035	309	2198											
LRRC8A	56262	broad.mit.edu	37	chr9	131671590	131671590	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccagaacctagccatcaCggccaaccgggtgagtggcc	9	5	11	16	2	1	2	1	1	0	1	2	2	2	2	7	3	3	0	7	3	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:131671590C>T	uc004bwl.3	+	3	2401	c.2147C>T	c.(2146-2148)ACG>ATG	p.T716M	LRRC8A_uc010myp.2_Missense_Mutation_p.T716M|LRRC8A_uc010myq.2_Missense_Mutation_p.T716M	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	716	LRR 15.				pre-B cell differentiation	integral to membrane					0						CTAGCCATCACGGCCAACCGG	0.667													29	71					0	0	0	0	T	131671590	T	T	131671590	3	4	8	1	0	0	0	0	1	0	0	0	9071	536	19	1	2149	1	LRRC8A	9	131671590	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1408194	131671590	9541841	310	2199											
RALGDS	5900	broad.mit.edu	37	chr9	135975666	135975666	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgacttactccggtcatctGagagaatctgcagcagctca	10	10	9	12	1	4	3	2	2	2	1	5	4	5	3	1	1	4	3	1	1	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:135975666G>C	uc004cco.2	-	17	2578	c.2558C>G	c.(2557-2559)TCA>TGA	p.S853*	RALGDS_uc004cct.1_5'Flank|RALGDS_uc004ccn.2_Nonsense_Mutation_p.S41*|RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Nonsense_Mutation_p.S841*|RALGDS_uc004ccr.2_Nonsense_Mutation_p.S852*|RALGDS_uc011mcv.1_Nonsense_Mutation_p.S824*|RALGDS_uc004ccs.2_Nonsense_Mutation_p.S798*|RALGDS_uc011mcw.1_Nonsense_Mutation_p.S924*|RALGDS_uc004ccv.1_3'UTR|RALGDS_uc004ccu.1_3'UTR	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	853	Ras-associating.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CCGGTCATCTGAGAGAATCTG	0.582			T	CIITA	PMBL|Hodgkin Lymphona|								79	253					0	0	0	0	C	135975666	C	C	135975666	4	2	8	1	0	0	0	0	0	1	0	0	13081	1294	45	2	194	2	RALGDS	9	135975666	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4304076	135975666	5237765	311	2200											
C9orf116	138162	broad.mit.edu	37	chr9	138391608	138391608	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcccggcaggtccgcgctCacgcggtagtagtcgctggt	4	8	15	14	6	1	0	1	0	0	0	3	0	2	0	2	4	1	5	2	4	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:138391608C>G	uc004cft.1	-	1	154	c.90G>C	c.(88-90)GTG>GTC	p.V30V	C9orf116_uc004cfs.1_Silent_p.V30V|C9orf116_uc004cfu.1_RNA|MRPS2_uc004cfv.3_5'Flank|MRPS2_uc004cfw.3_5'Flank|MRPS2_uc004cfx.3_5'Flank|MRPS2_uc010nat.2_5'Flank	NM_001048265	NP_001041730	Q5BN46	CI116_HUMAN	hypothetical protein LOC138162 isoform 1	30											0				OV - Ovarian serous cystadenocarcinoma(145;7.39e-08)|Epithelial(140;5.19e-07)|all cancers(34;1.04e-05)		GGTCCGCGCTCACGCGGTAGT	0.697													3	19					0	0	0	0	G	138391608	G	G	138391608	2	3	8	1	0	0	0	0	0	0	0	1	2462	813	29	2		2	C9orf116	9	138391608	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2415942	138391608	2821823	312	2201											
C8G	733	broad.mit.edu	37	chr9	139840549	139840549	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccccagcccgagacgcccGaggggctgtgcacgtggttg	5	6	16	14	4	0	1	0	0	0	1	0	3	0	1	4	3	3	3	4	3	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:139840549G>A	uc004cka.2	+	4	434	c.359G>A	c.(358-360)CGA>CAA	p.R120Q	FBXW5_uc004cjx.2_5'Flank|FBXW5_uc004cjy.2_5'Flank|FBXW5_uc004cjz.2_5'Flank	NM_000606	NP_000597	P07360	CO8G_HUMAN	complement component 8, gamma polypeptide	120					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex	retinol binding|transporter activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.88e-06)|Epithelial(140;0.000107)		CGAGACGCCCGAGGGGCTGTG	0.642													16	23					0	0	0	0	A	139840549	A	A	139840549	3	1	8	1	0	0	0	0	1	0	0	0	2429	1058	37	1	373	1	C8G	9	139840549	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1448941	139840549	1372882	313	2202											
DIP2C	22982	broad.mit.edu	37	chr10	436786	436786	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttccaagcaagaaacctatCtgctggctccctgcgtcctg	8	10	8	15	1	1	1	0	0	1	1	4	1	4	1	4	1	4	3	4	1	4	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:436786C>G	uc001ifp.2	-	11	1368	c.1278G>C	c.(1276-1278)CAG>CAC	p.Q426H	DIP2C_uc009xhj.1_Missense_Mutation_p.Q122H	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	426						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		AGAAACCTATCTGCTGGCTCC	0.562													34	121					0	0	0	0	G	436786	G	G	436786	3	3	8	1	0	0	0	0	1	0	0	0	4551	912	32	2	3500	2	DIP2C	10	436786	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		436786	135097961	314	2203											
NET1	10276	broad.mit.edu	37	chr10	5495245	5495245	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccatgttaaagttgtccatCatgtcagaagaggaactcac	13	10	8	10	0	3	2	3	0	0	2	4	3	4	3	2	1	1	2	2	1	4	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:5495245C>T	uc001iia.2	+	7	765	c.627C>T	c.(625-627)ATC>ATT	p.I209I	NET1_uc010qar.1_Silent_p.I28I|NET1_uc001iib.2_Silent_p.I155I|NET1_uc010qas.1_Silent_p.I28I	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	209	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						AGTTGTCCATCATGTCAGAAG	0.408													49	164					0	0	0	0	T	5495245	T	T	5495245	2	4	8	1	0	0	0	0	0	0	0	1	10392	816	29	2		2	NET1	10	5495245	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5058459	5495245	130039502	315	2204											
FBXO18	84893	broad.mit.edu	37	chr10	5951160	5951160	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgctctccgagtgtggatcCcgagagggtgctgtggagtc	5	10	17	9	2	1	1	0	0	1	1	4	5	2	3	2	3	2	2	2	3	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:5951160C>T	uc001iis.2	+	5	1018	c.923C>T	c.(922-924)CCC>CTC	p.P308L	FBXO18_uc001iir.2_Missense_Mutation_p.P234L|FBXO18_uc009xig.2_Missense_Mutation_p.P234L|FBXO18_uc001iit.2_Missense_Mutation_p.P359L	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	308					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						AGTGTGGATCCCGAGAGGGTG	0.592													19	67					0	0	0	0	T	5951160	T	T	5951160	3	4	8	1	0	0	0	0	1	0	0	0	5763	623	22	4	1103	4	FBXO18	10	5951160	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	455915	5951160	129583587	316	2205											
ITIH2	3698	broad.mit.edu	37	chr10	7769773	7769773	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgctgatcattttggtttctGatggagatccaacagtgggc	8	13	12	8	1	2	3	1	2	1	1	3	4	3	3	1	3	1	2	1	3	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:7769773G>C	uc001ijs.2	+	11	1423	c.1261G>C	c.(1261-1263)GAT>CAT	p.D421H		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	421	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TTTGGTTTCTGATGGAGATCC	0.453													15	47					0	0	0	0	C	7769773	C	C	7769773	3	2	8	1	0	0	0	0	1	0	0	0	7943	1290	45	2	1303	2	ITIH2	10	7769773	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1818613	7769773	127764974	317	2206											
CUBN	8029	broad.mit.edu	37	chr10	16957877	16957877	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcacagccagaagaattctGaaggttaaagtcttcaaaag	16	10	8	7	0	4	3	2	1	2	2	4	3	4	3	1	1	1	1	1	1	7	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:16957877G>A	uc001ioo.2	-	46	7205	c.7153C>T	c.(7153-7155)CAG>TAG	p.Q2385*		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2385	CUB 17.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAAGAATTCTGAAGGTTAAAG	0.413													14	94					0	0	0	0	A	16957877	A	A	16957877	4	1	8	1	0	0	0	0	0	1	0	0	4068	1299	45	2	3806	2	CUBN	10	16957877	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	9188104	16957877	118576870	318	2207											
CACNB2	783	broad.mit.edu	37	chr10	18827162	18827162	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgaggatgcctgtgagcaCcttgccgactatctggaggc	7	10	13	11	1	1	2	0	2	1	0	1	5	1	4	3	3	3	1	3	3	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:18827162C>G	uc001ipr.2	+	13	1416	c.1356C>G	c.(1354-1356)CAC>CAG	p.H452Q	CACNB2_uc009xjz.1_Missense_Mutation_p.H202Q|CACNB2_uc001ips.2_Missense_Mutation_p.H428Q|CACNB2_uc001ipt.2_Missense_Mutation_p.H414Q|CACNB2_uc001ipu.2_Missense_Mutation_p.H424Q|CACNB2_uc001ipv.2_Missense_Mutation_p.H400Q|CACNB2_uc009xka.1_Missense_Mutation_p.H386Q|CACNB2_uc001ipw.2_Missense_Mutation_p.H359Q|CACNB2_uc001ipx.2_Missense_Mutation_p.H397Q|CACNB2_uc001ipz.2_Missense_Mutation_p.H374Q|CACNB2_uc001ipy.2_Missense_Mutation_p.H398Q|CACNB2_uc010qco.1_Missense_Mutation_p.H366Q|CACNB2_uc001iqa.2_Missense_Mutation_p.H404Q|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	452					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCTGTGAGCACCTTGCCGACT	0.552													47	134					0	0	0	0	G	18827162	G	G	18827162	3	3	8	1	0	0	0	0	1	0	0	0	2565	506	18	4	1716	4	CACNB2	10	18827162	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1869285	18827162	116707585	319	2208											
DNAJC1	64215	broad.mit.edu	37	chr10	22208791	22208791	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctgaagcaccgagttttGatacatccacactcttgctg	9	14	7	11	1	2	2	0	2	2	0	3	3	3	2	2	0	3	3	2	0	2	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:22208791G>C	uc001irc.2	-	5	892	c.605C>G	c.(604-606)TCA>TGA	p.S202*	DNAJC1_uc001ird.2_Nonsense_Mutation_p.S88*	NM_022365	NP_071760	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	202	Cytoplasmic (By similarity).				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			lung(1)	1		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				ACCGAGTTTTGATACATCCAC	0.299													34	123					0	0	0	0	C	22208791	C	C	22208791	4	2	8	1	0	0	0	0	0	1	0	0	4650	1294	45	2	1091	2	DNAJC1	10	22208791	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3381629	22208791	113325956	320	2209											
MYO3A	53904	broad.mit.edu	37	chr10	26286125	26286125	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taacaacaaaactatccacaGagatgtgaaaggcaataaca	21	6	6	8	0	0	2	0	1	0	1	1	3	1	2	1	1	4	1	1	1	8	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:26286125G>C	uc001isn.2	+	6	806	c.446G>C	c.(445-447)AGA>ACA	p.R149T	MYO3A_uc009xko.1_Missense_Mutation_p.R149T|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.R149T|MYO3A_uc001ism.2_Missense_Mutation_p.R149T	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	149	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						ACTATCCACAGAGATGTGAAA	0.308													20	61					0	0	0	0	C	26286125	C	C	26286125	3	2	8	1	0	0	0	0	1	0	0	0	10129	942	33	2	460	2	MYO3A	10	26286125	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4077334	26286125	109248622	321	2210											
KIAA1462	57608	broad.mit.edu	37	chr10	30317643	30317643	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgacgggggtattaagctCtgtggattccaaatggcacc	9	9	12	11	2	1	0	0	0	1	0	2	2	2	1	3	4	1	3	3	4	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:30317643C>G	uc001iux.2	-	2	1493	c.1434G>C	c.(1432-1434)CAG>CAC	p.Q478H	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.Q340H|KIAA1462_uc009xle.1_Missense_Mutation_p.Q478H	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	478										ovary(4)	4						GTATTAAGCTCTGTGGATTCC	0.572													43	124					0	0	0	0	G	30317643	G	G	30317643	3	3	8	1	0	0	0	0	1	0	0	0	8273	912	32	2	2653	2	KIAA1462	10	30317643	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4031518	30317643	105217104	322	2211											
CUL2	8453	broad.mit.edu	37	chr10	35327992	35327992	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgacatcgaatttcttcatCttttaatctacctagaacct	11	16	3	11	2	4	1	1	0	3	1	6	3	4	1	2	0	2	0	2	0	5	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:35327992C>G	uc001ixv.2	-	9	943	c.733G>C	c.(733-735)GAT>CAT	p.D245H	CUL2_uc009xma.2_Missense_Mutation_p.D114H|CUL2_uc010qer.1_Missense_Mutation_p.D264H|CUL2_uc001ixw.2_Missense_Mutation_p.D245H|CUL2_uc010qes.1_Missense_Mutation_p.D182H	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	245					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						ATTTCTTCATCTTTTAATCTA	0.323													10	41					0	0	0	0	G	35327992	G	G	35327992	3	3	8	1	0	0	0	0	1	0	0	0	4072	913	32	2	1556	2	CUL2	10	35327992	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5010349	35327992	100206755	323	2212											
MAPK8	5599	broad.mit.edu	37	chr10	49618178	49618178	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatcagatgctgtgtggaatCaagcaccttcattctgctgg	9	13	10	9	0	4	1	3	0	1	1	4	2	4	2	1	2	3	3	1	2	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:49618178C>G	uc009xnz.2	+	5	641	c.417C>G	c.(415-417)ATC>ATG	p.I139M	MAPK8_uc001jgl.2_Missense_Mutation_p.I139M|MAPK8_uc001jgm.2_Missense_Mutation_p.I139M|MAPK8_uc001jgo.2_Missense_Mutation_p.I139M|MAPK8_uc009xoa.2_Missense_Mutation_p.I139M|MAPK8_uc001jgn.2_Missense_Mutation_p.I139M|MAPK8_uc010qgk.1_Missense_Mutation_p.I139M|MAPK8_uc001jgp.2_Missense_Mutation_p.I139M|MAPK8_uc001jgq.2_Missense_Mutation_p.I139M	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	139	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		TGTGTGGAATCAAGCACCTTC	0.348													3	145					0	0	0	0	G	49618178	G	G	49618178	3	3	8	1	0	0	0	0	1	0	0	0	9336	816	29	2	431	2	MAPK8	10	49618178	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	14290186	49618178	85916569	324	2213											
PCDH15	65217	broad.mit.edu	37	chr10	55782797	55782797	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aatgacgagggtgtactgctCcatctgttgccacaacaaca	12	9	9	11	1	1	1	0	1	1	0	2	2	2	1	2	1	5	3	2	1	4	2	rs146468805		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:55782797C>G	uc001jju.1	-	19	2776	c.2381G>C	c.(2380-2382)GGA>GCA	p.G794A	PCDH15_uc010qhq.1_Missense_Mutation_p.G799A|PCDH15_uc010qhr.1_Missense_Mutation_p.G794A|PCDH15_uc010qhs.1_Missense_Mutation_p.G806A|PCDH15_uc010qht.1_Missense_Mutation_p.G801A|PCDH15_uc010qhu.1_Missense_Mutation_p.G794A|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.G794A|PCDH15_uc010qhw.1_Missense_Mutation_p.G757A|PCDH15_uc010qhx.1_Missense_Mutation_p.G723A|PCDH15_uc010qhy.1_Missense_Mutation_p.G799A|PCDH15_uc010qhz.1_Missense_Mutation_p.G794A|PCDH15_uc010qia.1_Missense_Mutation_p.G772A|PCDH15_uc010qib.1_Missense_Mutation_p.G772A|PCDH15_uc001jjw.2_Missense_Mutation_p.G794A	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	794	Extracellular (Potential).|Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GTGTACTGCTCCATCTGTTGC	0.423										HNSCC(58;0.16)			27	99					0	0	0	0	G	55782797	G	G	55782797	3	3	8	1	0	0	0	0	1	0	0	0	11565	855	30	2	5165	2	PCDH15	10	55782797	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	6164619	55782797	79751950	325	2214											
USP54	159195	broad.mit.edu	37	chr10	75335391	75335391	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtacactaccacgaccccctGaaaaataatttctcttccaa	14	10	3	14	1	1	1	0	1	1	0	3	2	2	1	4	0	2	1	4	0	6	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:75335391G>A	uc001juo.2	-	1	43	c.26C>T	c.(25-27)TCA>TTA	p.S9L	USP54_uc001jup.2_Missense_Mutation_p.S9L|USP54_uc010qkl.1_Missense_Mutation_p.S9L	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	9					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					ACGACCCCCTGAAAAATAATT	0.448													18	105					0	0	0	0	A	75335391	A	A	75335391	3	1	8	1	0	0	0	0	1	0	0	0	17153	1294	45	2	5116	2	USP54	10	75335391	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	19552594	75335391	60199356	326	2215											
MYST4	23522	broad.mit.edu	37	chr10	76789241	76789241	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctttgacccaggagagcagCgaacaggacgacacctttca	12	7	10	12	2	2	2	1	1	1	1	2	6	2	3	2	2	3	1	2	2	1	2	rs147158118		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:76789241C>T	uc001jwn.1	+	18	5152	c.4659C>T	c.(4657-4659)AGC>AGT	p.S1553S	MYST4_uc001jwo.1_Silent_p.S1261S|MYST4_uc001jwp.1_Silent_p.S1370S	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1553					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					AGGAGAGCAGCGAACAGGACG	0.527			T	CREBBP	AML								15	110					0	0	0	0	T	76789241	T	T	76789241	2	4	8	1	0	0	0	0	0	0	0	1	10158	767	27	1		1	MYST4	10	76789241	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1453850	76789241	58745506	327	2216											
TLL2	7093	broad.mit.edu	37	chr10	98146809	98146809	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgatgctcgcacccgccgtGatctggccaggaacactcat	8	7	11	15	4	2	1	1	1	1	0	3	3	2	2	3	2	2	2	3	2	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:98146809G>C	uc001kml.1	-	14	1979	c.1753C>G	c.(1753-1755)CAC>GAC	p.H585D		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	585	EGF-like 1; calcium-binding (Potential).			EVDECSWPDHGGCEHRCV -> GKKKKKKKKKKKKKKKKK (in Ref. 5; AAH13871).	cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CACCCGCCGTGATCTGGCCAG	0.592													18	48					0	0	0	0	C	98146809	C	C	98146809	3	2	8	1	0	0	0	0	1	0	0	0	16012	1290	45	2	1326	2	TLL2	10	98146809	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	21357568	98146809	37387938	328	2217											
PIK3AP1	118788	broad.mit.edu	37	chr10	98362077	98362077	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aggcaccctggggggtctctCgagggacatggtgggtgtcc	5	8	18	10	1	1	0	0	0	1	0	4	2	2	1	2	7	0	1	2	7	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:98362077C>G	uc001kmq.2	-	16	2448	c.2320G>C	c.(2320-2322)GAG>CAG	p.E774Q	PIK3AP1_uc001kmo.2_Missense_Mutation_p.E373Q|PIK3AP1_uc001kmp.2_Missense_Mutation_p.E596Q	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	774	Pro-rich.					cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		GGGGGTCTCTCGAGGGACATG	0.507													26	40					0	0	0	0	G	98362077	G	G	98362077	3	3	8	1	0	0	0	0	1	0	0	0	11963	893	31	3	105	3	PIK3AP1	10	98362077	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	215268	98362077	37172670	329	2218											
CRTAC1	55118	broad.mit.edu	37	chr10	99655057	99655057	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtagcctgagcccccgtcGatgatcctcaggtgggcccc	6	7	13	15	2	1	2	1	2	0	0	3	3	2	2	6	3	2	1	6	3	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:99655057G>A	uc001kou.1	-	11	1787	c.1431C>T	c.(1429-1431)ATC>ATT	p.I477I	CRTAC1_uc001kov.2_Silent_p.I466I|CRTAC1_uc001kot.1_Silent_p.I267I	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	477						proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		AGCCCCCGTCGATGATCCTCA	0.632													18	36					0	0	0	0	A	99655057	A	A	99655057	2	1	8	1	0	0	0	0	0	0	0	1	3911	1048	37	1		1	CRTAC1	10	99655057	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1292980	99655057	35879690	330	2219											
POLL	27343	broad.mit.edu	37	chr10	103344383	103344383	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tacgaggtgacaggcttatgGaagctcttgagggcattgat	10	11	14	6	1	1	3	0	3	1	0	1	5	1	4	0	4	2	3	0	4	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:103344383G>T	uc001ktg.1	-	4	1633	c.867C>A	c.(865-867)TTC>TTA	p.F289L	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_5'Flank|POLL_uc001kth.1_Intron|POLL_uc001kti.1_Missense_Mutation_p.F289L|POLL_uc001ktj.1_Missense_Mutation_p.F289L|POLL_uc001ktf.2_Intron|POLL_uc001ktk.1_Intron|POLL_uc010qqa.1_Intron|POLL_uc010qqb.1_Intron|POLL_uc001ktm.2_Missense_Mutation_p.F289L|POLL_uc001ktl.2_Missense_Mutation_p.F201L|POLL_uc010qqc.1_Intron|POLL_uc010qqd.1_Missense_Mutation_p.S147Y	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	289					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		CAGGCTTATGGAAGCTCTTGA	0.562								DNA_polymerases_(catalytic_subunits)					14	51					1.05317e-09	1.10443e-09	1	0	T	103344383	T	T	103344383	3	4	8	1	0	0	0	0	1	0	0	0	12260	1165	41	2	880	2	POLL	10	103344383	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3689326	103344383	32190364	331	2220											
CCDC147	159686	broad.mit.edu	37	chr10	106152107	106152107	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaacctatatgaagctgtGagatcagacagaaatctgta	16	9	9	7	0	2	5	1	2	1	4	2	6	2	5	1	0	2	2	1	0	6	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:106152107G>C	uc001kyh.2	+	10	1616	c.1482G>C	c.(1480-1482)GTG>GTC	p.V494V		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	494	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ATGAAGCTGTGAGATCAGACA	0.299													22	117					0	0	0	0	C	106152107	C	C	106152107	2	2	8	1	0	0	0	0	0	0	0	1	2793	1277	45	2		2	CCDC147	10	106152107	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2807724	106152107	29382640	332	2221											
ADRB1	153	broad.mit.edu	37	chr10	115804636	115804636	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtgtacctgcgggtgttcCgcgaggcccagaagcaggtg	6	8	16	11	4	0	1	0	0	0	1	2	2	1	1	3	3	3	3	3	3	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:115804636C>T	uc001lba.2	+	1	831	c.745C>T	c.(745-747)CGC>TGC	p.R249C		NM_000684	NP_000675	P08588	ADRB1_HUMAN	beta-1-adrenergic receptor	249	Cytoplasmic (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	GCGGGTGTTCCGCGAGGCCCA	0.547													10	22					0	0	0	0	T	115804636	T	T	115804636	3	4	8	1	0	0	0	0	1	0	0	0	340	652	23	1	747	1	ADRB1	10	115804636	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	9652529	115804636	19730111	333	2222											
PNLIPRP1	5407	broad.mit.edu	37	chr10	118354333	118354333	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acaggctgccaacaacgtgcGagtggtgggcgcccaggtgg	8	5	17	11	3	0	0	0	0	0	0	0	1	0	0	2	5	4	1	2	5	2	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:118354333G>C	uc001lco.1	+	5	440	c.422G>C	c.(421-423)CGA>CCA	p.R141P	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.R141P|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	141					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		AACAACGTGCGAGTGGTGGGC	0.592													10	62					0	0	0	0	C	118354333	C	C	118354333	3	2	8	1	0	0	0	0	1	0	0	0	12205	1058	37	3	436	3	PNLIPRP1	10	118354333	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2549697	118354333	17180414	334	2223											
PDZD8	118987	broad.mit.edu	37	chr10	119044202	119044202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacgataaagaatttctgatGattcccatgtttgacggtcg	11	14	9	7	3	1	4	0	3	1	1	3	5	2	4	1	1	1	1	1	1	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:119044202G>A	uc001lde.1	-	5	2241	c.2042C>T	c.(2041-2043)TCA>TTA	p.S681L		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	681					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		AATTTCTGATGATTCCCATGT	0.413													12	100					0	0	0	0	A	119044202	A	A	119044202	3	1	8	1	0	0	0	0	1	0	0	0	11759	1294	45	2	1426	2	PDZD8	10	119044202	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	689869	119044202	16490545	335	2224											
TACC2	10579	broad.mit.edu	37	chr10	123976183	123976183	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagaaacaccaccagtgatCtctgcggtggtccacgccac	10	6	9	16	2	1	2	0	1	1	1	3	2	2	2	5	2	2	0	5	2	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:123976183C>G	uc001lfv.2	+	11	7746	c.7386C>G	c.(7384-7386)ATC>ATG	p.I2462M	TACC2_uc001lfw.2_Missense_Mutation_p.I608M|TACC2_uc009xzx.2_Missense_Mutation_p.I2417M|TACC2_uc010qtv.1_Missense_Mutation_p.I2466M|TACC2_uc001lfx.2_Missense_Mutation_p.I166M|TACC2_uc001lfy.2_Missense_Mutation_p.I162M|TACC2_uc001lfz.2_Missense_Mutation_p.I540M|TACC2_uc001lga.2_Missense_Mutation_p.I540M|TACC2_uc009xzy.2_Missense_Mutation_p.I552M|TACC2_uc001lgb.2_Missense_Mutation_p.I497M|TACC2_uc010qtw.1_Missense_Mutation_p.I557M	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2462						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CACCAGTGATCTCTGCGGTGG	0.537													4	101					0	0	0	0	G	123976183	G	G	123976183	3	3	8	1	0	0	0	0	1	0	0	0	15568	903	32	2	7496	2	TACC2	10	123976183	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4931981	123976183	11558564	336	2225											
DOCK1	1793	broad.mit.edu	37	chr10	129207596	129207596	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatattcagtgcttcacagtGaagcccaaactcgatctgcc	11	10	8	12	1	3	1	2	1	1	0	4	3	3	1	2	0	4	1	2	0	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:129207596G>A	uc001ljt.2	+	42	4285	c.4221G>A	c.(4219-4221)GTG>GTA	p.V1407V	DOCK1_uc010qun.1_Silent_p.V1428V|DOCK1_uc009yaq.2_Silent_p.V402V	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1407	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GCTTCACAGTGAAGCCCAAAC	0.493													12	95					0	0	0	0	A	129207596	A	A	129207596	2	1	8	1	0	0	0	0	0	0	0	1	4706	1277	45	2		2	DOCK1	10	129207596	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5231413	129207596	6327151	337	2226											
EBF3	253738	broad.mit.edu	37	chr10	131640406	131640406	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgttggcttgtgacgtctctGacacgttgacggctagctgg	5	12	14	10	4	1	3	0	3	1	0	2	3	1	3	0	3	1	5	0	3	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:131640406G>A	uc001lki.1	-	13	1378	c.1319C>T	c.(1318-1320)TCA>TTA	p.S440L		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	449					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		TGACGTCTCTGACACGTTGAC	0.612													35	92					0	0	0	0	A	131640406	A	A	131640406	3	1	8	1	0	0	0	0	1	0	0	0	4904	1294	45	2	352	2	EBF3	10	131640406	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2432810	131640406	3894341	338	2227											
JAKMIP3	282973	broad.mit.edu	37	chr10	133946815	133946815	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgttctgttctccttgtaGatggaggagataaaatttaa	11	16	10	4	0	2	2	0	0	2	2	3	4	2	3	1	2	0	3	1	2	4	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:133946815G>C	uc001lkx.3	+	3	634	c.634_splice	c.e3-1	p.M212_splice		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TCTCCTTGTAGATGGAGGAGA	0.537													3	10					0	0	0	0	C	133946815	C	C	133946815	5	2	8	1	0	0	0	0	0	0	1	0	7981	956	33	2	643	2	JAKMIP3	10	133946815	Splice_Site	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2306409	133946815	1587932	339	2228											
PTDSS2	81490	broad.mit.edu	37	chr11	479110	479110	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaggttttggctctgcgtGagtgtggtctacgagctgtt	4	15	16	6	2	2	1	0	1	2	0	2	3	2	2	0	4	3	4	0	4	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:479110G>C	uc001lpj.2	+	4	569	c.393G>C	c.(391-393)GTG>GTC	p.V131V	PTDSS2_uc009ybv.1_Silent_p.V131V	NM_030783	NP_110410	Q9BVG9	PTSS2_HUMAN	phosphatidylserine synthase 2	131	Helical; (Potential).					integral to membrane					0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;2.76e-26)|Epithelial(43;2.56e-25)|OV - Ovarian serous cystadenocarcinoma(40;7.54e-20)|BRCA - Breast invasive adenocarcinoma(625;8.76e-05)|Lung(200;0.0407)|LUSC - Lung squamous cell carcinoma(625;0.0735)	Phosphatidylserine(DB00144)	GGCTCTGCGTGAGTGTGGTCT	0.567													60	236					0	0	0	0	C	479110	C	C	479110	2	2	8	1	0	0	0	0	0	0	0	1	12799	1277	45	2		2	PTDSS2	11	479110	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08		479110	134527406	340	2229											
PHRF1	57661	broad.mit.edu	37	chr11	605232	605232	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagccctctttggggctgctGagagcggatattggagctgc	6	10	16	9	1	1	1	0	1	1	1	1	5	1	3	1	4	5	3	1	4	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:605232G>A	uc001lqe.2	+	11	1397	c.1266G>A	c.(1264-1266)CTG>CTA	p.L422L	PHRF1_uc010qwc.1_Silent_p.L422L|PHRF1_uc010qwd.1_Silent_p.L421L|PHRF1_uc010qwe.1_Silent_p.L418L|PHRF1_uc009ybz.1_Silent_p.L213L|PHRF1_uc009yca.1_5'Flank	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	422							RNA polymerase binding|zinc ion binding				0						TGGGGCTGCTGAGAGCGGATA	0.597													33	95					0	0	0	0	A	605232	A	A	605232	2	1	8	1	0	0	0	0	0	0	0	1	11916	1277	45	2		2	PHRF1	11	605232	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	126122	605232	134401284	341	2230											
PHLDA2	7262	broad.mit.edu	37	chr11	2950434	2950434	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgcagtccaccttgaggatgGagtggaagcgcagctccttg	8	8	14	11	2	0	1	0	1	0	0	2	4	2	4	3	3	2	3	3	3	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:2950434G>C	uc001lxa.1	-	1	217	c.161C>G	c.(160-162)TCC>TGC	p.S54C		NM_003311	NP_003302	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain family A member	54	PH.				apoptosis	cytoplasm|membrane					0		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTGAGGATGGAGTGGAAGCG	0.657													8	45					0	0	0	0	C	2950434	C	C	2950434	3	2	8	1	0	0	0	0	1	0	0	0	11904	1174	41	2	301	2	PHLDA2	11	2950434	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2345202	2950434	132056082	342	2231											
DCHS1	8642	broad.mit.edu	37	chr11	6662141	6662141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcagggcctgggccctcCgggggggtgaaccaccatca	7	4	15	15	1	1	1	1	1	0	0	2	1	2	1	6	5	2	1	6	5	1	0	rs143767864	byFrequency	TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:6662141C>T	uc001mem.1	-	2	1114	c.704G>A	c.(703-705)CGG>CAG	p.R235Q		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	235	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGGCCCTCCGGGGGGGTGA	0.587													10	145					0	0	0	0	T	6662141	T	T	6662141	3	4	8	1	0	0	0	0	1	0	0	0	4304	652	23	1	9272	1	DCHS1	11	6662141	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3711707	6662141	128344375	343	2232											
SBF2	81846	broad.mit.edu	37	chr11	9875240	9875240	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actctctgtatcatagctctCagctacacttcctgcaatac	10	13	4	14	0	3	0	2	0	2	0	6	0	4	0	1	0	5	4	1	0	5	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:9875240C>G	uc001mib.2	-	20	2521	c.2383G>C	c.(2383-2385)GAG>CAG	p.E795Q	SBF2_uc001mif.3_Missense_Mutation_p.E551Q|uc001mig.2_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	795					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TCATAGCTCTCAGCTACACTT	0.373													18	142					0	0	0	0	G	9875240	G	G	9875240	3	3	8	1	0	0	0	0	1	0	0	0	13924	835	29	2	3250	2	SBF2	11	9875240	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3213099	9875240	125131276	344	2233											
MICAL2	9645	broad.mit.edu	37	chr11	12263802	12263802	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggcacgtgctcagagagctCaagcaagtgtctgctggcag	9	7	15	10	1	3	1	2	0	1	1	3	2	3	1	0	2	4	6	0	2	2	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:12263802C>G	uc001mjz.2	+	19	2667	c.2379C>G	c.(2377-2379)CTC>CTG	p.L793L	MICAL2_uc010rch.1_Intron|MICAL2_uc001mka.2_Silent_p.L793L|MICAL2_uc010rci.1_Silent_p.L793L|MICAL2_uc001mkb.2_Intron|MICAL2_uc001mkc.2_Intron|MICAL2_uc001mkd.2_Intron|MICAL2_uc010rcj.1_Intron|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	793						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TCAGAGAGCTCAAGCAAGTGT	0.562													10	29					0	0	0	0	G	12263802	G	G	12263802	2	3	8	1	0	0	0	0	0	0	0	1	9623	813	29	2		2	MICAL2	11	12263802	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2388562	12263802	122742714	345	2234											
BTBD10	84280	broad.mit.edu	37	chr11	13427228	13427228	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgaatattcttctcccatCtgtggtggatattcttcatc	7	18	7	9	0	5	1	1	1	4	0	7	2	5	2	1	2	0	0	1	2	3	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:13427228C>T	uc001mkz.2	-	7	1241	c.984G>A	c.(982-984)CAG>CAA	p.Q328Q	BTBD10_uc010rcl.1_Silent_p.Q336Q|BTBD10_uc001mla.2_Silent_p.Q312Q|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Silent_p.Q280Q|BTBD10_uc010rcn.1_Silent_p.Q297Q|BTBD10_uc009ygo.2_Silent_p.Q280Q	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	328						nucleus					0				Epithelial(150;0.0214)		CTTCTCCCATCTGTGGTGGAT	0.423													50	147					0	0	0	0	T	13427228	T	T	13427228	2	4	8	1	0	0	0	0	0	0	0	1	1543	912	32	2		2	BTBD10	11	13427228	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1163426	13427228	121579288	346	2235											
COPB1	1315	broad.mit.edu	37	chr11	14520460	14520460	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attaacgtgtagcatacgttCtcagccgccgtcatggtttc	8	13	9	11	4	2	0	2	0	1	0	4	0	2	0	2	1	4	4	2	1	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:14520460C>G	uc001mli.2	-	2	322	c.15G>C	c.(13-15)GAG>GAC	p.E5D	COPB1_uc001mlg.2_Missense_Mutation_p.E5D|COPB1_uc001mlh.2_Missense_Mutation_p.E5D|PSMA1_uc010rcp.1_RNA	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	5					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						AGCATACGTTCTCAGCCGCCG	0.343													12	40					0	0	0	0	G	14520460	G	G	14520460	3	3	8	1	0	0	0	0	1	0	0	0	3743	912	32	2	2930	2	COPB1	11	14520460	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1093232	14520460	120486056	347	2236											
PSMA1	5682	broad.mit.edu	37	chr11	14539457	14539457	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaaaactgcatgagtttttGatttcagaccaactgtggct	11	13	8	9	0	1	3	1	2	0	1	1	3	1	3	2	1	3	3	2	1	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:14539457G>C	uc001mlk.2	-	3	265	c.119C>G	c.(118-120)TCA>TGA	p.S40*	PSMA1_uc001mll.2_Nonsense_Mutation_p.S46*|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_Nonsense_Mutation_p.S15*|PSMA1_uc010rcq.1_Nonsense_Mutation_p.S40*	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	40					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						ATGAGTTTTTGATTTCAGACC	0.318													18	37					0	0	0	0	C	14539457	C	C	14539457	4	2	8	1	0	0	0	0	0	1	0	0	12728	1294	45	2	754	2	PSMA1	11	14539457	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	18997	14539457	120467059	348	2237											
NUCB2	4925	broad.mit.edu	37	chr11	17333590	17333590	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttagttggagaaagtatatGaccctaaaaatgaagaggat	17	11	10	3	0	0	4	0	2	0	2	0	6	0	5	1	2	0	2	1	2	8	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:17333590G>C	uc001mmw.2	+	10	1080	c.835G>C	c.(835-837)GAC>CAC	p.D279H	NUCB2_uc001mmv.1_Missense_Mutation_p.D279H|NUCB2_uc009ygz.2_Missense_Mutation_p.D279H	NM_005013	NP_005004	P80303	NUCB2_HUMAN	nucleobindin 2 precursor	279	Binds to necdin (By similarity).					cytosol|ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|plasma membrane	calcium ion binding|DNA binding				0						GAAAGTATATGACCCTAAAAA	0.299													10	133					0	0	0	0	C	17333590	C	C	17333590	3	2	8	1	0	0	0	0	1	0	0	0	10773	1290	45	2	865	2	NUCB2	11	17333590	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2794133	17333590	117672926	349	2238											
ANO5	203859	broad.mit.edu	37	chr11	22281213	22281213	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccacatcactcacaggatCatgcttgaactttattgtca	13	12	5	11	0	4	1	4	1	0	0	4	2	4	2	1	1	3	1	1	1	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:22281213C>T	uc001mqi.2	+	15	1873	c.1556C>T	c.(1555-1557)TCA>TTA	p.S519L	ANO5_uc001mqj.2_Missense_Mutation_p.S518L	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	519	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						CTCACAGGATCATGCTTGAAC	0.378													20	61					0	0	0	0	T	22281213	T	T	22281213	3	4	8	1	0	0	0	0	1	0	0	0	700	838	29	2	1614	2	ANO5	11	22281213	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4947623	22281213	112725303	350	2239											
ANO5	203859	broad.mit.edu	37	chr11	22301235	22301235	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caaattaaaagagaacttggGaattaattctaatgaatttg	18	13	7	3	0	1	2	0	1	1	1	1	4	1	3	0	1	1	0	0	1	8	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:22301235G>T	uc001mqi.2	+	22	2983	c.2666G>T	c.(2665-2667)GGA>GTA	p.G889V	ANO5_uc001mqj.2_Missense_Mutation_p.G888V	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	889	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						GAGAACTTGGGAATTAATTCT	0.363													7	75					0.00198382	0.00201499	1	0	T	22301235	T	T	22301235	3	4	8	1	0	0	0	0	1	0	0	0	700	1174	41	2	2752	2	ANO5	11	22301235	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	20022	22301235	112705281	351	2240											
LRRC4C	57689	broad.mit.edu	37	chr11	40137420	40137420	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaagtatacaaaagctccAttcgggatggtagtaagacg	15	8	11	7	2	0	1	0	0	0	1	2	3	1	2	1	2	2	4	1	2	7	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:40137420A>T	uc001mxa.1	-	2	2387	c.423T>A	c.(421-423)AAT>AAA	p.N141K	LRRC4C_uc001mxc.1_Missense_Mutation_p.N137K|LRRC4C_uc001mxd.1_Missense_Mutation_p.N137K|LRRC4C_uc001mxb.1_Missense_Mutation_p.N137K	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	141	LRR 3.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CAAAAGCTCCATTCGGGATGG	0.428													20	62					0	0	0	0	T	40137420	T	T	40137420	3	4	8	1	0	0	0	0	1	0	0	0	9058	214	8	5	1503	5	LRRC4C	11	40137420	Missense_Mutation	SNP	A	TCGA-BA-5152-01A-02D-1870-08	17836185	40137420	94869096	352	2241											
PHF21A	51317	broad.mit.edu	37	chr11	45975109	45975109	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctcccgttttggtttgggtGcagcaggtggggtgatggtg	3	13	18	7	1	0	1	0	1	0	0	1	1	1	1	2	6	2	4	2	6	0	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:45975109G>T	uc001ncc.3	-	10	1685	c.1061C>A	c.(1060-1062)GCA>GAA	p.A354E	PHF21A_uc001ncb.3_Missense_Mutation_p.A355E|PHF21A_uc009ykx.2_Missense_Mutation_p.A355E|PHF21A_uc001nce.2_Missense_Mutation_p.A355E|PHF21A_uc001nca.1_Missense_Mutation_p.A90E	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	354					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						TGGTTTGGGTGCAGCAGGTGG	0.448													6	51					1.12685e-05	1.16283e-05	1	0	T	45975109	T	T	45975109	3	4	8	1	0	0	0	0	1	0	0	0	11888	1319	46	4	1044	4	PHF21A	11	45975109	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5837689	45975109	89031407	353	2242											
LRP4	4038	broad.mit.edu	37	chr11	46897369	46897369	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcacctcggtgtgggcatCggcccatagcagttgggagc	6	9	14	12	2	1	0	1	0	1	0	4	1	1	1	2	4	2	3	2	4	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:46897369C>T	uc001ndn.3	-	26	3831	c.3685G>A	c.(3685-3687)GAT>AAT	p.D1229N		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1229	Extracellular (Potential).|LDL-receptor class B 14.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GTGTGGGCATCGGCCCATAGC	0.597													8	62					0	0	0	0	T	46897369	T	T	46897369	3	4	8	1	0	0	0	0	1	0	0	0	9009	884	31	1	2084	1	LRP4	11	46897369	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	922260	46897369	88109147	354	2243											
OR5AP2	338675	broad.mit.edu	37	chr11	56409589	56409589	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccaggaaggagccaaaGaagtagaactgggcagcaca	15	3	13	10	0	0	2	0	0	0	2	1	4	1	4	3	3	3	3	3	3	5	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:56409589G>T	uc001njb.1	-	1	327	c.327C>A	c.(325-327)TTC>TTA	p.F109L		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						AGGAGCCAAAGAAGTAGAACT	0.512													17	41					0.006122	0.00619167	1	0	T	56409589	T	T	56409589	3	4	8	1	0	0	0	0	1	0	0	0	11198	933	33	2	627	2	OR5AP2	11	56409589	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	9512220	56409589	78596927	355	2244											
RTN4RL2	349667	broad.mit.edu	37	chr11	57235099	57235099	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcccgcctcggcctgcCtcctgctgatgctcctggcc	2	9	10	20	2	0	1	0	1	0	0	4	1	3	1	7	2	4	3	7	2	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:57235099C>G	uc010rjt.1	+	2	49	c.49C>G	c.(49-51)CTC>GTC	p.L17V		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	17					axon regeneration	anchored to plasma membrane	receptor activity				0						CTCGGCCTGCCTCCTGCTGAT	0.677													32	105					0	0	0	0	G	57235099	G	G	57235099	3	3	8	1	0	0	0	0	1	0	0	0	13797	681	24	4	55	4	RTN4RL2	11	57235099	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	825510	57235099	77771417	356	2245											
OR5A1	219982	broad.mit.edu	37	chr11	59211187	59211187	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcatcaaccacttcttctgCgacctcccaccagtcctggc	8	10	5	18	1	4	0	2	0	2	0	6	1	6	0	5	1	2	0	5	1	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:59211187C>T	uc001nnx.1	+	1	546	c.546C>T	c.(544-546)TGC>TGT	p.C182C		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						ACTTCTTCTGCGACCTCCCAC	0.537													73	251					0	0	0	0	T	59211187	T	T	59211187	2	4	8	1	0	0	0	0	0	0	0	1	11193	776	27	1		1	OR5A1	11	59211187	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1976088	59211187	75795329	357	2246											
AHNAK	79026	broad.mit.edu	37	chr11	62286867	62286867	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacactaatttcaggagtctCaaggttcagctctgcctcag	11	11	8	11	0	5	0	4	0	2	0	6	1	5	1	1	2	3	2	1	2	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:62286867C>G	uc001ntl.2	-	5	15322	c.15022G>C	c.(15022-15024)GAG>CAG	p.E5008Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5008					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCAGGAGTCTCAAGGTTCAGC	0.423													58	147					0	0	0	0	G	62286867	G	G	62286867	3	3	8	1	0	0	0	0	1	0	0	0	414	835	29	2	2770	2	AHNAK	11	62286867	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3075680	62286867	72719649	358	2247											
MACROD1	28992	broad.mit.edu	37	chr11	63767135	63767135	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accgagcggagccggtgctcCagcagcaggtccagactgct	8	5	14	14	3	0	1	0	0	0	1	2	3	2	2	4	3	6	4	4	3	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:63767135C>T	uc001nyh.2	-	6	884	c.765G>A	c.(763-765)CTG>CTA	p.L255L		NM_014067	NP_054786	Q9BQ69	MACD1_HUMAN	MACRO domain containing 1	255	Macro.										0						GCCGGTGCTCCAGCAGCAGGT	0.716													4	22					0	0	0	0	T	63767135	T	T	63767135	2	4	8	1	0	0	0	0	0	0	0	1	9196	581	21	4		4	MACROD1	11	63767135	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1480268	63767135	71239381	359	2248											
FERMT3	83706	broad.mit.edu	37	chr11	63974990	63974990	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctcctgaagattgtggagCagatcagtgagtgtccgctg	8	11	14	8	1	1	4	1	2	0	2	3	5	3	5	2	1	2	3	2	1	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:63974990C>G	uc001nyl.2	+	2	303	c.154C>G	c.(154-156)CAG>GAG	p.Q52E	FERMT3_uc001nym.2_Missense_Mutation_p.Q52E	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	52					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						GATTGTGGAGCAGATCAGTGA	0.667													11	61					0	0	0	0	G	63974990	G	G	63974990	3	3	8	1	0	0	0	0	1	0	0	0	5851	711	25	4	156	4	FERMT3	11	63974990	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	207855	63974990	71031526	360	2249											
BAD	572	broad.mit.edu	37	chr11	64037697	64037697	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaggtcactgggagggggcgGagcttcccctgcccaagttc	7	7	15	12	1	1	0	1	0	0	0	3	2	2	2	3	5	2	2	3	5	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:64037697G>A	uc001nzd.2	-	4	573	c.491C>T	c.(490-492)TCC>TTC	p.S164F	BAD_uc001nzc.2_Missense_Mutation_p.S164F|GPR137_uc009ypj.1_5'UTR	NM_032989	NP_116784	Q92934	BAD_HUMAN	BCL2-associated agonist of cell death	164					activation of pro-apoptotic gene products|ADP metabolic process|ATP metabolic process|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to nicotine|glucose homeostasis|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|pore complex assembly|positive regulation of epithelial cell proliferation|positive regulation of glucokinase activity|positive regulation of insulin secretion|positive regulation of mitochondrial membrane potential|positive regulation of type B pancreatic cell development|regulation of mitochondrial membrane permeability|type B pancreatic cell proliferation	cytosol|mitochondrial outer membrane	caspase activator activity|phospholipid binding|protein kinase binding			central_nervous_system(1)	1						GGAGGGGGCGGAGCTTCCCCT	0.637													11	42					0	0	0	0	A	64037697	A	A	64037697	3	1	8	1	0	0	0	0	1	0	0	0	1287	1174	41	2	19	2	BAD	11	64037697	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	62707	64037697	70968819	361	2250											
GPR137	56834	broad.mit.edu	37	chr11	64054131	64054131	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctccgtctatgcccagctCtggctggtgcttctgtatgg	3	15	11	12	1	4	0	0	0	4	0	5	0	4	0	2	3	3	4	2	3	2	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:64054131C>G	uc001nzg.1	+	2	443	c.135C>G	c.(133-135)CTC>CTG	p.L45L	BAD_uc001nzd.2_5'Flank|BAD_uc001nzc.2_5'Flank|GPR137_uc009ypj.1_Silent_p.L51L|BAD_uc009ypk.2_5'Flank|GPR137_uc010rni.1_Silent_p.L103L|GPR137_uc001nze.1_Silent_p.L45L|GPR137_uc001nzf.2_Silent_p.L45L|GPR137_uc001nzh.1_Silent_p.L45L|GPR137_uc001nzi.2_Silent_p.L45L|GPR137_uc010rnj.1_Silent_p.L45L	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	45	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						ATGCCCAGCTCTGGCTGGTGC	0.627													44	138					0	0	0	0	G	64054131	G	G	64054131	2	3	8	1	0	0	0	0	0	0	0	1	6683	900	32	2		2	GPR137	11	64054131	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	16434	64054131	70952385	362	2251											
ESRRA	2101	broad.mit.edu	37	chr11	64082296	64082296	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctgaccccgcaggccctGatgggcacctcccagccgtg	5	6	12	18	2	0	2	0	2	0	0	1	2	1	2	7	2	2	2	7	2	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:64082296G>A	uc001nzq.1	+	5	832	c.655G>A	c.(655-657)GAT>AAT	p.D219N	ESRRA_uc001nzr.1_Missense_Mutation_p.D218N|ESRRA_uc001nzs.1_Missense_Mutation_p.D219N|ESRRA_uc009ypn.1_Intron	NM_004451	NP_004442	P11474	ERR1_HUMAN	estrogen-related receptor alpha	219	Ligand binding domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0						CGCAGGCCCTGATGGGCACCT	0.587													12	59					0	0	0	0	A	64082296	A	A	64082296	3	1	8	1	0	0	0	0	1	0	0	0	5284	1290	45	2	669	2	ESRRA	11	64082296	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	28165	64082296	70924220	363	2252											
RASGRP2	10235	broad.mit.edu	37	chr11	64510267	64510267	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccctcccgagccactcaccGaaggcttcgatgcacccgcg	7	5	10	19	5	1	0	1	0	0	0	3	3	2	0	5	1	2	2	5	1	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:64510267G>A	uc009ypu.2	-	2	299	c.72C>T	c.(70-72)TTC>TTT	p.F24F	RASGRP2_uc001oat.2_5'Flank|RASGRP2_uc001oau.2_5'Flank|RASGRP2_uc009ypv.2_Silent_p.F24F|RASGRP2_uc009ypw.2_Silent_p.F24F|RASGRP2_uc001oaw.1_Missense_Mutation_p.S327L	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	24	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						GCCACTCACCGAAGGCTTCGA	0.726													4	18					0	0	0	0	A	64510267	A	A	64510267	2	1	8	1	0	0	0	0	0	0	0	1	13140	1072	37	1		1	RASGRP2	11	64510267	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	427971	64510267	70496249	364	2253											
ATG2A	23130	broad.mit.edu	37	chr11	64673226	64673226	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctggtacctatagtccacaGagcaggagaacaggtgtgtg	11	8	13	9	0	0	2	0	0	0	2	1	3	1	2	3	3	3	2	3	3	4	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:64673226G>A	uc001obx.2	-	23	3474	c.3359C>T	c.(3358-3360)TCT>TTT	p.S1120F	ATG2A_uc001obw.2_5'Flank	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1120							protein binding			ovary(1)|central_nervous_system(1)	2						ATAGTCCACAGAGCAGGAGAA	0.632													7	84					0	0	0	0	A	64673226	A	A	64673226	3	1	8	1	0	0	0	0	1	0	0	0	1095	942	33	2	2533	2	ATG2A	11	64673226	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	162959	64673226	70333290	365	2254											
EFEMP2	30008	broad.mit.edu	37	chr11	65635368	65635368	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccctgcgagtttccagcacgGatctgaaaggcattgtaggc	9	9	12	11	2	1	1	0	1	1	0	2	3	2	2	2	3	2	4	2	3	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:65635368G>T	uc001ofy.3	-	10	1328	c.1134C>A	c.(1132-1134)ATC>ATA	p.I378I	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Silent_p.I378I	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	378					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		TTCCAGCACGGATCTGAAAGG	0.547													33	116					2.68265e-12	2.83834e-12	1	0	T	65635368	T	T	65635368	2	4	8	1	0	0	0	0	0	0	0	1	4964	1164	41	2		2	EFEMP2	11	65635368	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	962142	65635368	69371148	366	2255											
TSGA10IP	254187	broad.mit.edu	37	chr11	65727397	65727397	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acaaccccagcctggacccgGagtgcagtccctgagataaa	12	5	10	14	1	0	1	0	1	0	1	1	4	1	3	5	2	3	1	5	2	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:65727397G>A	uc001ogk.1	+	10	1689	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K	TSGA10IP_uc009yqw.1_RNA|TSGA10IP_uc009yqx.1_RNA|SART1_uc009yqy.1_5'Flank|SART1_uc010rot.1_5'Flank|SART1_uc001ogl.2_5'Flank	NM_152762	NP_689975	Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein	553											0						CCTGGACCCGGAGTGCAGTCC	0.562													5	21					0	0	0	0	A	65727397	A	A	65727397	3	1	8	1	0	0	0	0	1	0	0	0	16685	1175	41	2	1687	2	TSGA10IP	11	65727397	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	92029	65727397	69279119	367	2256											
RBM4B	83759	broad.mit.edu	37	chr11	66436418	66436418	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagttgtgctttggacttGaggcagatgggacatggtct	8	12	14	7	0	1	2	0	1	1	1	1	4	1	4	0	4	1	3	0	4	0	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:66436418G>C	uc001oja.2	-	2	1426	c.757C>G	c.(757-759)CAA>GAA	p.Q253E	RBM4B_uc001ojb.2_Missense_Mutation_p.Q253E	NM_031492	NP_113680	Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	253	Interaction with TNPO3 (By similarity).				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding				0						CTTTGGACTTGAGGCAGATGG	0.542													4	158					0	0	0	0	C	66436418	C	C	66436418	3	2	8	1	0	0	0	0	1	0	0	0	13207	1299	45	2	326	2	RBM4B	11	66436418	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	709021	66436418	68570098	368	2257											
RBM4B	83759	broad.mit.edu	37	chr11	66436492	66436492	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgctgctactgcctcataaGagcggacccggtatcgctta	8	9	10	14	4	1	1	1	0	0	1	2	2	1	2	3	2	4	4	3	2	4	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:66436492G>C	uc001oja.2	-	2	1352	c.683C>G	c.(682-684)TCT>TGT	p.S228C	RBM4B_uc001ojb.2_Missense_Mutation_p.S228C	NM_031492	NP_113680	Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	228	Interaction with TNPO3 (By similarity).				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding				0						TGCCTCATAAGAGCGGACCCG	0.537													3	76					0	0	0	0	C	66436492	C	C	66436492	3	2	8	1	0	0	0	0	1	0	0	0	13207	942	33	2	400	2	RBM4B	11	66436492	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	74	66436492	68570024	369	2258											
IGHMBP2	3508	broad.mit.edu	37	chr11	68707045	68707045	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgcgcccatgcccggcagaGaatcagccgggaaggggtcc	8	4	15	14	4	1	1	1	0	0	1	3	3	2	2	4	4	2	1	4	4	2	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:68707045G>A	uc001ook.1	+	15	2930	c.2828G>A	c.(2827-2829)AGA>AAA	p.R943K	IGHMBP2_uc001ool.1_Missense_Mutation_p.R567K	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	943					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCCCGGCAGAGAATCAGCCGG	0.642													16	60					0	0	0	0	A	68707045	A	A	68707045	3	1	8	1	0	0	0	0	1	0	0	0	7630	942	33	2	2886	2	IGHMBP2	11	68707045	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2270553	68707045	66299471	370	2259											
PDE2A	5138	broad.mit.edu	37	chr11	72290599	72290599	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccgggagaaatgatcaaaGatgttgcagccgtgggtgtt	10	11	14	6	2	1	3	1	1	0	2	2	4	2	3	2	2	2	3	2	2	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:72290599G>T	uc010rrc.1	-	26	2478	c.2235C>A	c.(2233-2235)ATC>ATA	p.I745I	PDE2A_uc001oso.2_Silent_p.I724I|PDE2A_uc010rra.1_Silent_p.I738I|PDE2A_uc001osn.2_Silent_p.I489I|PDE2A_uc010rrb.1_Silent_p.I736I|PDE2A_uc010rrd.1_Silent_p.I630I	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	745	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	AATGATCAAAGATGTTGCAGC	0.418													14	70					4.7546e-09	4.97136e-09	1	0	T	72290599	T	T	72290599	2	4	8	1	0	0	0	0	0	0	0	1	11690	932	33	2		2	PDE2A	11	72290599	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3583554	72290599	62715917	371	2260											
ARHGEF17	9828	broad.mit.edu	37	chr11	73073674	73073674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgagggtgacccccgcccaGagctggtgccctttgacagt	6	7	14	14	2	0	3	0	2	0	1	0	4	0	3	4	2	2	1	4	2	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:73073674G>A	uc001otu.2	+	14	4912	c.4891G>A	c.(4891-4893)GAG>AAG	p.E1631K		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1631					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CCCCCGCCCAGAGCTGGTGCC	0.687													17	35					0	0	0	0	A	73073674	A	A	73073674	3	1	8	1	0	0	0	0	1	0	0	0	900	943	33	2	4945	2	ARHGEF17	11	73073674	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	783075	73073674	61932842	372	2261											
MYO7A	4647	broad.mit.edu	37	chr11	76891443	76891443	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtggcgcctcgaggctgaGaaaatgcggctggcggagga	8	6	18	9	4	0	1	0	1	0	1	1	5	0	3	1	6	1	2	1	6	2	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:76891443G>C	uc001oyb.2	+	22	2882	c.2610G>C	c.(2608-2610)GAG>GAC	p.E870D	MYO7A_uc010rsl.1_Missense_Mutation_p.E870D|MYO7A_uc010rsm.1_Missense_Mutation_p.E859D|MYO7A_uc001oyc.2_Missense_Mutation_p.E870D|MYO7A_uc001oyd.2_Missense_Mutation_p.E210D|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Missense_Mutation_p.E81D	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	870	Potential.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						TCGAGGCTGAGAAAATGCGGC	0.597													12	23					0	0	0	0	C	76891443	C	C	76891443	3	2	8	1	0	0	0	0	1	0	0	0	10135	933	33	2	2692	2	MYO7A	11	76891443	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3817769	76891443	58115073	373	2262											
BIRC3	330	broad.mit.edu	37	chr11	102195714	102195714	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagatttttctgccttgatGagaagttcctaccactgtgc	9	14	8	10	0	1	3	0	2	1	2	2	4	2	3	3	0	3	1	3	0	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:102195714G>A	uc001pgx.2	+	3	696	c.474G>A	c.(472-474)ATG>ATA	p.M158I		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	baculoviral IAP repeat-containing protein 3	158					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|skin(1)	4	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		CTGCCTTGATGAGAAGTTCCT	0.408			T	MALT1	MALT								60	147					0	0	0	0	A	102195714	A	A	102195714	3	1	8	1	0	0	0	0	1	0	0	0	1439	1290	45	2	476	2	BIRC3	11	102195714	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	25304271	102195714	32810802	374	2263											
DYNC2H1	79659	broad.mit.edu	37	chr11	103047052	103047052	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcacccggtttgatgcactGataaaagatgtctttccggg	9	12	11	9	2	1	3	0	2	1	1	2	3	2	3	2	2	2	3	2	2	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:103047052G>C	uc001pho.2	+	37	5907	c.5763G>C	c.(5761-5763)CTG>CTC	p.L1921L	DYNC2H1_uc001phn.1_Silent_p.L1921L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1921					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTGATGCACTGATAAAAGATG	0.363													5	18					0	0	0	0	C	103047052	C	C	103047052	2	2	8	1	0	0	0	0	0	0	0	1	4868	1277	45	2		2	DYNC2H1	11	103047052	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	851338	103047052	31959464	375	2264											
CASP5	838	broad.mit.edu	37	chr11	104871152	104871152	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatgccatgagacatgagtAccaagaacgtgctgtcagag	13	7	13	8	1	1	4	1	2	0	3	1	6	1	5	2	1	4	2	2	1	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:104871152A>T	uc010rva.1	-	6	820	c.788T>A	c.(787-789)GTA>GAA	p.V263E	CASP5_uc010ruz.1_Missense_Mutation_p.V276E|CASP5_uc010rvb.1_Missense_Mutation_p.V205E|CASP5_uc010rvc.1_Missense_Mutation_p.V121E|CASP5_uc009yxh.2_Missense_Mutation_p.V45E|CASP5_uc010rvd.1_Missense_Mutation_p.V45E	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	263					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		AGACATGAGTACCAAGAACGT	0.458													22	81					0	0	0	0	T	104871152	T	T	104871152	3	4	8	1	0	0	0	0	1	0	0	0	2686	391	14	5	532	5	CASP5	11	104871152	Missense_Mutation	SNP	A	TCGA-BA-5152-01A-02D-1870-08	1824100	104871152	30135364	376	2265											
CUL5	8065	broad.mit.edu	37	chr11	107975080	107975080	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacatcagaagagatgaatCtgatatcaacactttcatat	17	12	5	7	0	4	4	3	2	1	2	4	5	4	4	0	0	2	0	0	0	6	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:107975080C>G	uc001pjv.2	+	19	2979	c.2312C>G	c.(2311-2313)TCT>TGT	p.S771C	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	771					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		AGAGATGAATCTGATATCAAC	0.308													29	112					0	0	0	0	G	107975080	G	G	107975080	3	3	8	1	0	0	0	0	1	0	0	0	4076	913	32	2	2386	2	CUL5	11	107975080	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3103928	107975080	27031436	377	2266											
SIK3	23387	broad.mit.edu	37	chr11	116730297	116730297	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgcgggaaggtaagccttGaaactgggaagaagatgcag	14	6	15	6	1	0	3	0	1	0	2	0	5	0	5	1	3	4	2	1	3	5	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:116730297G>C	uc001ppy.2	-	19	2167	c.2131C>G	c.(2131-2133)CAA>GAA	p.Q711E	SIK3_uc001ppz.2_Missense_Mutation_p.Q610E|SIK3_uc001pqa.2_Missense_Mutation_p.Q711E|SIK3_uc001ppw.2_Missense_Mutation_p.Q128E|SIK3_uc001ppx.2_Missense_Mutation_p.Q149E|SIK3_uc001pqb.2_Missense_Mutation_p.Q14E	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	711	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						GGTAAGCCTTGAAACTGGGAA	0.537											OREG0003491	type=REGULATORY REGION|Gene=AK022302|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	64					0	0	0	0	C	116730297	C	C	116730297	3	2	8	1	0	0	0	0	1	0	0	0	14384	1299	45	2	1680	2	SIK3	11	116730297	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8755217	116730297	18276219	378	2267											
UBE4A	9354	broad.mit.edu	37	chr11	118239345	118239345	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagtatacattttctggcaGatgaactcccagctagccca	12	10	7	12	0	1	2	0	1	1	1	2	2	2	2	2	1	4	3	2	1	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:118239345G>C	uc001psw.2	+	3	251	c.122_splice	c.e3-1	p.D41_splice	UBE4A_uc001psv.2_Splice_Site_p.D41_splice	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TTTTCTGGCAGATGAACTCCC	0.413													87	249					0	0	0	0	C	118239345	C	C	118239345	5	2	8	1	0	0	0	0	0	0	1	0	16950	956	33	2	127	2	UBE4A	11	118239345	Splice_Site	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1509048	118239345	16767171	379	2268											
TRAPPC4	51399	broad.mit.edu	37	chr11	118892481	118892481	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctccagggatcaagtttGtggttctagcagatcctagg	8	13	11	9	0	3	1	1	0	2	1	6	2	5	2	2	3	1	3	2	3	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:118892481G>C	uc010ryo.1	+	4	731	c.466G>C	c.(466-468)GTG>CTG	p.V156L	TRAPPC4_uc010ryp.1_Missense_Mutation_p.V102L|TRAPPC4_uc001pup.2_RNA|TRAPPC4_uc010ryq.1_Intron	NM_016146	NP_057230	Q9Y296	TPPC4_HUMAN	trafficking protein particle complex 4	156					dendrite development|ER to Golgi vesicle-mediated transport	cis-Golgi network|dendrite|endoplasmic reticulum|Golgi stack|synaptic vesicle	protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		GATCAAGTTTGTGGTTCTAGC	0.338													13	60					0	0	0	0	C	118892481	C	C	118892481	3	2	8	1	0	0	0	0	1	0	0	0	16528	1377	48	4	480	4	TRAPPC4	11	118892481	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	653136	118892481	16114035	380	2269											
FAM118B	79607	broad.mit.edu	37	chr11	126110786	126110786	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgccccaagttccagccctCaaatcctggaaggggttaat	10	8	10	13	1	1	0	1	0	0	0	3	1	3	1	5	3	1	2	5	3	4	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:126110786C>G	uc001qdf.2	+	4	369	c.186C>G	c.(184-186)CTC>CTG	p.L62L	FAM118B_uc009zca.2_Silent_p.L66L|FAM118B_uc001qdg.2_Silent_p.L62L	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	62											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		TTCCAGCCCTCAAATCCTGGA	0.453													74	256					0	0	0	0	G	126110786	G	G	126110786	2	3	8	1	0	0	0	0	0	0	0	1	5440	813	29	2		2	FAM118B	11	126110786	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7218305	126110786	8895730	381	2270											
ADAMTS8	11095	broad.mit.edu	37	chr11	130275461	130275461	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgcccccctgaatcacagggGgcacagctggctttcgcagg	7	7	13	14	1	1	1	1	1	0	0	2	1	1	1	3	4	2	4	3	4	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:130275461G>A	uc001qgg.3	-	9	3020	c.2662C>T	c.(2662-2664)CCC>TCC	p.P888S	ADAMTS8_uc001qgf.2_Missense_Mutation_p.P369S	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	888	TSP type-1 2.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		AATCACAGGGGGCACAGCTGG	0.637													14	97					0	0	0	0	A	130275461	A	A	130275461	3	1	8	1	0	0	0	0	1	0	0	0	272	1232	43	4	11	4	ADAMTS8	11	130275461	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4164675	130275461	4731055	382	2271											
IQSEC3	440073	broad.mit.edu	37	chr12	278251	278251	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcccagggggacccacagtCaaagcaaggatcgccgacag	13	2	13	13	2	1	0	1	0	0	0	2	3	1	2	3	3	2	1	3	3	2	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:278251C>T	uc001qhw.1	+	9	2141	c.2135C>T	c.(2134-2136)TCA>TTA	p.S712L	IQSEC3_uc001qhu.1_Missense_Mutation_p.S712L	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	1015					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GACCCACAGTCAAAGCAAGGA	0.642													32	64					0	0	0	0	T	278251	T	T	278251	3	4	8	1	0	0	0	0	1	0	0	0	7858	838	29	2	3090	2	IQSEC3	12	278251	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		278251	133573644	383	2272											
VWF	7450	broad.mit.edu	37	chr12	6103292	6103292	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgctgcacagtccattcctGaacaagtgttttccagtctg	8	12	8	13	1	1	1	0	1	1	0	4	1	4	1	4	0	2	3	4	0	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:6103292G>A	uc001qnn.1	-	37	6584	c.6334C>T	c.(6334-6336)CAG>TAG	p.Q2112*	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2112	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GTCCATTCCTGAACAAGTGTT	0.542													12	51					0	0	0	0	A	6103292	A	A	6103292	4	1	8	1	0	0	0	0	0	1	0	0	17314	1299	45	2	2171	2	VWF	12	6103292	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5825041	6103292	127748603	384	2273											
VWF	7450	broad.mit.edu	37	chr12	6103365	6103365	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggctccgttctcatcacaGatccctagagaaacaaacaa	14	9	6	12	1	2	2	2	0	1	2	5	3	4	2	2	1	2	2	2	1	4	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:6103365G>T	uc001qnn.1	-	37	6511	c.6261C>A	c.(6259-6261)ATC>ATA	p.I2087I	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2087	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	TCTCATCACAGATCCCTAGAG	0.478													14	42					2.61681e-11	2.76047e-11	1	0	T	6103365	T	T	6103365	2	4	8	1	0	0	0	0	0	0	0	1	17314	932	33	2		2	VWF	12	6103365	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	73	6103365	127748530	385	2274											
SCNN1A	6337	broad.mit.edu	37	chr12	6457124	6457124	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcccagggtggcataggcaGggggaggggctgtcaaggct	7	5	21	8	0	1	0	1	0	0	0	1	1	1	1	1	9	0	4	1	9	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:6457124G>A	uc001qnx.2	-	13	2214	c.1925C>T	c.(1924-1926)CCT>CTT	p.P642L	SCNN1A_uc001qnv.2_Missense_Mutation_p.P342L|SCNN1A_uc001qnw.2_Missense_Mutation_p.P701L|SCNN1A_uc010sfb.1_Missense_Mutation_p.P665L	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	642	Cytoplasmic (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	ggcataggcagggggaggggc	0.244													4	9					0	0	0	0	A	6457124	A	A	6457124	3	1	8	1	0	0	0	0	1	0	0	0	13992	1000	35	4	88	4	SCNN1A	12	6457124	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	353759	6457124	127394771	386	2275											
LAG3	3902	broad.mit.edu	37	chr12	6887472	6887472	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctccgcaggctcagagcaaGatagaggagctggagcaaga	13	4	14	10	1	1	4	1	0	0	4	2	6	2	6	2	3	3	5	2	3	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:6887472G>C	uc001qqt.3	+	8	1843	c.1494G>C	c.(1492-1494)AAG>AAC	p.K498N	LAG3_uc001qqu.2_3'UTR	NM_002286	NP_002277	P18627	LAG3_HUMAN	lymphocyte-activation protein 3 precursor	498	Cytoplasmic (Potential).					integral to membrane	antigen binding|MHC class II protein binding				0						CTCAGAGCAAGATAGAGGAGC	0.313													11	28					0	0	0	0	C	6887472	C	C	6887472	3	2	8	1	0	0	0	0	1	0	0	0	8640	933	33	2	1524	2	LAG3	12	6887472	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	430348	6887472	126964423	387	2276											
APOLD1	81575	broad.mit.edu	37	chr12	12940238	12940238	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgccaggaccagatgcgagaGatcctgagctgcctcgagtt	9	8	13	11	2	0	3	0	1	0	2	2	7	1	4	4	1	4	2	4	1	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:12940238G>A	uc001rau.3	+	2	576	c.492G>A	c.(490-492)GAG>GAA	p.E164E	DDX47_uc001rav.2_Intron|APOLD1_uc001raw.3_Silent_p.E133E	NM_001130415	NP_001123887	Q96LR9	APLD1_HUMAN	apolipoprotein L domain containing 1 isoform 1	164					angiogenesis|cell differentiation|lipid transport|lipoprotein metabolic process	extracellular region|integral to membrane|plasma membrane	lipid binding			ovary(1)	1		Prostate(47;0.0632)		BRCA - Breast invasive adenocarcinoma(232;0.0338)|GBM - Glioblastoma multiforme(207;0.149)		AGATGCGAGAGATCCTGAGCT	0.642													40	99					0	0	0	0	A	12940238	A	A	12940238	2	1	8	1	0	0	0	0	0	0	0	1	811	933	33	2		2	APOLD1	12	12940238	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	6052766	12940238	120911657	388	2277											
GSG1	83445	broad.mit.edu	37	chr12	13243458	13243458	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggttcttccacagtttcctCacaggatagccacatgccac	9	11	7	14	0	2	0	1	0	1	0	4	1	4	1	4	2	2	2	4	2	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:13243458C>T	uc001rbn.2	-	2	516	c.343G>A	c.(343-345)GAG>AAG	p.E115K	GSG1_uc001rbj.2_Missense_Mutation_p.E102K|GSG1_uc001rbk.2_Missense_Mutation_p.E102K|GSG1_uc001rbl.2_Missense_Mutation_p.E102K|GSG1_uc001rbm.2_Missense_Mutation_p.E102K|GSG1_uc001rbo.2_Missense_Mutation_p.E115K|GSG1_uc001rbp.2_Missense_Mutation_p.E115K|GSG1_uc001rbq.1_Missense_Mutation_p.E115K	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	102						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		ACAGTTTCCTCACAGGATAGC	0.542													21	53					0	0	0	0	T	13243458	T	T	13243458	3	4	8	1	0	0	0	0	1	0	0	0	6859	835	29	2	893	2	GSG1	12	13243458	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	303220	13243458	120608437	389	2278											
C12orf39	80763	broad.mit.edu	37	chr12	21680692	21680692	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttcatctccgaccagagccgGagaaaggacctctccgaccg	10	6	10	15	4	3	2	1	0	2	2	5	6	3	3	6	2	1	0	6	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:21680692G>C	uc001rfa.1	+	4	328	c.177G>C	c.(175-177)CGG>CGC	p.R59R	C12orf39_uc009ziv.1_RNA|C12orf39_uc009ziw.1_5'Flank	NM_030572	NP_085049	Q9BT56	SPXN_HUMAN	spexin precursor	59						extracellular region|nucleus|transport vesicle					0						ACCAGAGCCGGAGAAAGGACC	0.647													4	10					0	0	0	0	C	21680692	C	C	21680692	2	2	8	1	0	0	0	0	0	0	0	1	1690	1161	41	2		2	C12orf39	12	21680692	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8437234	21680692	112171203	390	2279											
PRPF40B	25766	broad.mit.edu	37	chr12	50029224	50029224	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgaaaagaggtttatgatGatgtcctcttcttcctggcc	9	14	9	9	1	2	3	0	2	2	1	5	4	4	3	3	2	0	1	3	2	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:50029224G>A	uc001rur.1	+	13	1241	c.1177G>A	c.(1177-1179)GAT>AAT	p.D393N	PRPF40B_uc001rup.1_Missense_Mutation_p.D415N|PRPF40B_uc001ruq.1_Missense_Mutation_p.D387N|PRPF40B_uc001rus.1_Missense_Mutation_p.D336N	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	393					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GGTTTATGATGATGTCCTCTT	0.512													46	154					0	0	0	0	A	50029224	A	A	50029224	3	1	8	1	0	0	0	0	1	0	0	0	12634	1290	45	2	1227	2	PRPF40B	12	50029224	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	28348532	50029224	83822671	391	2280											
BIN2	51411	broad.mit.edu	37	chr12	51685669	51685669	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gggggtgctgaggtcctctgGatagaggctctcttctttgg	4	13	16	8	0	3	2	0	1	3	1	5	3	4	3	1	6	1	2	1	6	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:51685669G>C	uc001ryg.2	-	10	1273	c.1221C>G	c.(1219-1221)ATC>ATG	p.I407M	BIN2_uc009zlz.2_Missense_Mutation_p.I375M|BIN2_uc001ryh.2_Missense_Mutation_p.I283M|BIN2_uc010sng.1_Missense_Mutation_p.I381M	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	407						cytoplasm	protein binding			ovary(1)	1						AGGTCCTCTGGATAGAGGCTC	0.587													29	93					0	0	0	0	C	51685669	C	C	51685669	3	2	8	1	0	0	0	0	1	0	0	0	1436	1164	41	2	492	2	BIN2	12	51685669	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1656445	51685669	82166226	392	2281											
KRT2	3849	broad.mit.edu	37	chr12	53045411	53045411	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgctcttgggccttcacattCtggatctctgggtcaacttt	5	15	9	12	1	5	0	2	0	3	0	6	1	5	1	1	3	1	1	1	3	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:53045411C>G	uc001sat.2	-	1	549	c.516G>C	c.(514-516)CAG>CAC	p.Q172H		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	172	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		CCTTCACATTCTGGATCTCTG	0.527													41	136					0	0	0	0	G	53045411	G	G	53045411	3	3	8	1	0	0	0	0	1	0	0	0	8496	912	32	2	1439	2	KRT2	12	53045411	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1359742	53045411	80806484	393	2282											
HNRNPA1	3178	broad.mit.edu	37	chr12	54675943	54675943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggcattaaagaagacactGaagaacatcacctaagagat	18	7	9	7	0	1	5	1	1	0	4	1	6	1	5	1	1	1	1	1	1	6	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:54675943G>A	uc001sfl.2	+	4	453	c.349G>A	c.(349-351)GAA>AAA	p.E117K	CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Missense_Mutation_p.E117K|HNRNPA1_uc009zng.2_Missense_Mutation_p.E117K|HNRNPA1_uc009znh.2_Missense_Mutation_p.E117K|HNRNPA1_uc009zni.2_Missense_Mutation_p.E117K|HNRNPA1_uc001sfn.2_Missense_Mutation_p.E117K|HNRNPA1_uc001sfo.3_RNA|HNRNPA1_uc001sfp.1_Missense_Mutation_p.E72K|HNRNPA1_uc009znj.1_Missense_Mutation_p.E72K	NM_031157	NP_112420	P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	117	Globular B domain.|RRM 2.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3						AGAAGACACTGAAGAACATCA	0.378													16	38					0	0	0	0	A	54675943	A	A	54675943	3	1	8	1	0	0	0	0	1	0	0	0	7296	1291	45	2	363	2	HNRNPA1	12	54675943	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1630532	54675943	79175952	394	2283											
COQ10A	93058	broad.mit.edu	37	chr12	56664084	56664084	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgtgaactgatgttccatGaggtgcaccagacttgaggc	9	9	12	11	1	0	5	0	4	0	1	1	5	1	5	3	2	2	2	3	2	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:56664084G>C	uc001sko.3	+	5	988	c.727G>C	c.(727-729)GAG>CAG	p.E243Q	COQ10A_uc001skp.3_Missense_Mutation_p.E211Q|COQ10A_uc001skq.3_Missense_Mutation_p.E226Q	NM_144576	NP_653177	Q96MF6	CQ10A_HUMAN	coenzyme Q10 homolog A isoform a	243						mitochondrial inner membrane				ovary(1)	1						GATGTTCCATGAGGTGCACCA	0.498													31	96					0	0	0	0	C	56664084	C	C	56664084	3	2	8	1	0	0	0	0	1	0	0	0	3758	1291	45	2	787	2	COQ10A	12	56664084	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1988141	56664084	77187811	395	2284											
DCTN2	10540	broad.mit.edu	37	chr12	57924487	57924487	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgctcactttcccagcttCttcatccgttcatcaatgct	6	16	5	14	1	5	0	4	0	1	0	7	0	7	0	2	0	3	4	2	0	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:57924487C>T	uc001som.1	-	14	1323	c.1191G>A	c.(1189-1191)AAG>AAA	p.K397K	DCTN2_uc009zpu.1_Silent_p.K402K|DCTN2_uc009zpv.1_Silent_p.K310K|DCTN2_uc009zpw.1_Silent_p.K310K|DCTN2_uc001soo.1_RNA|DCTN2_uc001son.1_Silent_p.K310K|DCTN2_uc001sop.1_Silent_p.K310K|DCTN2_uc001soq.1_RNA|DCTN2_uc009zpx.1_Silent_p.K373K	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	397	Potential.				cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			ovary(1)	1						TTCCCAGCTTCTTCATCCGTT	0.473													11	143					0	0	0	0	T	57924487	T	T	57924487	2	4	8	1	0	0	0	0	0	0	0	1	4324	912	32	2		2	DCTN2	12	57924487	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1260403	57924487	75927408	396	2285											
XPOT	11260	broad.mit.edu	37	chr12	64813889	64813889	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcataaaagataccatgaggGaacagtgcattccaaatctg	16	9	8	8	0	2	2	1	1	1	1	3	3	3	3	2	1	3	1	2	1	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:64813889G>A	uc001ssb.2	+	7	955	c.529G>A	c.(529-531)GAA>AAA	p.E177K	XPOT_uc009zqm.1_Missense_Mutation_p.E87K	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	177	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		TACCATGAGGGAACAGTGCAT	0.363													23	46					0	0	0	0	A	64813889	A	A	64813889	3	1	8	1	0	0	0	0	1	0	0	0	17518	1175	41	2	551	2	XPOT	12	64813889	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	6889402	64813889	69038006	397	2286											
CAPS2	84698	broad.mit.edu	37	chr12	75692498	75692498	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccaagtcggtattgttttCcttttcttcgtccacactga	7	16	6	12	2	1	1	0	1	1	0	5	1	3	1	3	1	0	2	3	1	2	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:75692498C>T	uc001sxk.3	-	12	1267	c.1070G>A	c.(1069-1071)GGA>GAA	p.G357E	CAPS2_uc001sxm.3_Missense_Mutation_p.G125E|CAPS2_uc009zsa.2_Intron|CAPS2_uc001sxi.3_Missense_Mutation_p.G93E|CAPS2_uc001sxj.3_Missense_Mutation_p.G268E|CAPS2_uc001sxl.3_Missense_Mutation_p.G338E	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	357							calcium ion binding			ovary(2)	2						GTATTGTTTTCCTTTTCTTCG	0.353													13	50					0	0	0	0	T	75692498	T	T	75692498	3	4	8	1	0	0	0	0	1	0	0	0	2650	855	30	2	631	2	CAPS2	12	75692498	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	10878609	75692498	58159397	398	2287											
SYT1	6857	broad.mit.edu	37	chr12	79689973	79689973	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgagacaaaagtccaccGaaaaacccttaatcctgtct	15	10	5	11	1	1	1	0	1	1	1	3	3	3	1	4	0	1	0	4	0	5	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:79689973G>T	uc001sys.2	+	8	1270	c.599G>T	c.(598-600)CGA>CTA	p.R200L	SYT1_uc001syt.2_Missense_Mutation_p.R200L|SYT1_uc001syu.2_Missense_Mutation_p.R197L|SYT1_uc001syv.2_Missense_Mutation_p.R200L	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	200	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 1.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						AAAGTCCACCGAAAAACCCTT	0.383													22	60					1.10923e-09	1.16151e-09	1	0	T	79689973	T	T	79689973	3	4	8	1	0	0	0	0	1	0	0	0	15531	1058	37	3	613	3	SYT1	12	79689973	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3997475	79689973	54161922	399	2288											
TMTC3	160418	broad.mit.edu	37	chr12	88547232	88547232	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaactttttctggacaacaaGagtagtgtgattgcttcttt	11	16	8	6	0	2	2	0	1	2	1	2	3	2	3	0	1	3	2	0	1	4	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:88547232G>C	uc001tau.2	+	3	574	c.354G>C	c.(352-354)AAG>AAC	p.K118N	TMTC3_uc009zsm.2_RNA	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	118						integral to membrane	binding			skin(1)	1						TGGACAACAAGAGTAGTGTGA	0.328													19	67					0	0	0	0	C	88547232	C	C	88547232	3	2	8	1	0	0	0	0	1	0	0	0	16328	933	33	2	360	2	TMTC3	12	88547232	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8857259	88547232	45304663	400	2289											
DEPDC4	120863	broad.mit.edu	37	chr12	100657384	100657384	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgttggaatcttcaaattCtaattccttttcttttttga	10	21	4	6	0	4	1	1	1	3	0	5	2	5	2	1	1	0	1	1	1	4	10			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:100657384C>A	uc001thi.2	-	2	448	c.445G>T	c.(445-447)GAA>TAA	p.E149*	DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Nonsense_Mutation_p.E82*|DEPDC4_uc009ztv.1_Nonsense_Mutation_p.E149*|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	149	DEP.				intracellular signal transduction						0						TCTTCAAATTCTAATTCCTTT	0.338													27	51					2.44723e-14	2.60087e-14	1	0	A	100657384	A	A	100657384	4	1	8	1	0	0	0	0	0	1	0	0	4463	922	32	2	455	2	DEPDC4	12	100657384	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	12110152	100657384	33194511	401	2290											
DEPDC4	120863	broad.mit.edu	37	chr12	100657450	100657450	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatactttgtgattcattaGaacttggcaaagatgaaccc	15	12	7	7	0	1	4	1	2	0	2	1	4	1	4	1	1	3	1	1	1	6	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:100657450G>C	uc001thi.2	-	2	382	c.379C>G	c.(379-381)CTA>GTA	p.L127V	DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Missense_Mutation_p.L60V|DEPDC4_uc009ztv.1_Missense_Mutation_p.L127V|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	127	DEP.				intracellular signal transduction						0						TGATTCATTAGAACTTGGCAA	0.358													31	71					0	0	0	0	C	100657450	C	C	100657450	3	2	8	1	0	0	0	0	1	0	0	0	4463	933	33	2	521	2	DEPDC4	12	100657450	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	66	100657450	33194445	402	2291											
PAH	5053	broad.mit.edu	37	chr12	103248921	103248921	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gatgtggacttactctgcagGaactgagaaacgtcttccag	11	10	11	9	1	2	1	0	1	2	1	3	5	3	3	1	2	4	1	1	2	3	2	rs62517208		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:103248921G>A	uc001tjq.1	-	7	1171	c.699C>T	c.(697-699)TTC>TTT	p.F233F	PAH_uc010swc.1_Silent_p.F233F	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	233			F -> L (in PKU; haplotypes 2,3).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	TACTCTGCAGGAACTGAGAAA	0.488													17	48					0	0	0	0	A	103248921	A	A	103248921	2	1	8	1	0	0	0	0	0	0	0	1	11448	1165	41	2		2	PAH	12	103248921	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2591471	103248921	30602974	403	2292											
C12orf45	121053	broad.mit.edu	37	chr12	105388468	105388468	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtccagcaagtaaaaaaaaGaaatagtcaaataaattatc	23	8	5	5	0	1	1	1	0	0	1	3	1	2	1	1	0	1	2	1	0	11	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:105388468G>C	uc001tlb.2	+	4	585	c.552G>C	c.(550-552)AAG>AAC	p.K184N		NM_152318	NP_689531	Q8N5I9	CL045_HUMAN	hypothetical protein LOC121053	184											0						GTAAAAAAAAGAAATAGTCAA	0.368													16	34					0	0	0	0	C	105388468	C	C	105388468	3	2	8	1	0	0	0	0	1	0	0	0	1697	933	33	2	566	2	C12orf45	12	105388468	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2139547	105388468	28463427	404	2293											
ALDH1L2	160428	broad.mit.edu	37	chr12	105446691	105446691	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcatttttaccatgatttCattgacctcctttgaaatct	9	18	5	9	0	2	3	1	3	1	0	3	3	3	3	3	1	1	1	3	1	2	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:105446691C>T	uc001tlc.2	-	11	1433	c.1306G>A	c.(1306-1308)GAA>AAA	p.E436K	ALDH1L2_uc009zuo.2_5'UTR|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	436					10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						ACCATGATTTCATTGACCTCC	0.363											OREG0022073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	55					0	0	0	0	T	105446691	T	T	105446691	3	4	8	1	0	0	0	0	1	0	0	0	495	835	29	2	1517	2	ALDH1L2	12	105446691	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	58223	105446691	28405204	405	2294											
ACACB	32	broad.mit.edu	37	chr12	109577263	109577263	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttctcctgtctgaccttttCctggttaaaaatctggggga	7	16	9	9	0	3	1	0	1	3	0	5	2	4	2	3	3	0	1	3	3	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:109577263C>G	uc001tob.2	+	2	172	c.53C>G	c.(52-54)TCC>TGC	p.S18C	ACACB_uc001toc.2_Missense_Mutation_p.S18C	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	18					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CTGACCTTTTCCTGGTTAAAA	0.433													10	91					0	0	0	0	G	109577263	G	G	109577263	3	3	8	1	0	0	0	0	1	0	0	0	107	855	30	2	55	2	ACACB	12	109577263	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4130572	109577263	24274632	406	2295											
ACACB	32	broad.mit.edu	37	chr12	109629726	109629726	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgcgatgttcagaacgtgCatgacagatttcttacactc	11	12	9	9	2	2	3	1	1	1	2	3	5	2	3	0	0	4	2	0	0	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:109629726C>T	uc001tob.2	+	15	2489	c.2370C>T	c.(2368-2370)TGC>TGT	p.C790C	ACACB_uc001toc.2_Silent_p.C790C	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	790					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TCAGAACGTGCATGACAGATT	0.517													6	76					0	0	0	0	T	109629726	T	T	109629726	2	4	8	1	0	0	0	0	0	0	0	1	107	718	25	4		4	ACACB	12	109629726	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	52463	109629726	24222169	407	2296											
TRAFD1	10906	broad.mit.edu	37	chr12	112590581	112590581	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagctggggatgcagaagagGaagaggaggagtaatggtgt	13	6	20	2	0	0	3	0	0	0	3	0	8	0	7	0	6	2	3	0	6	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:112590581G>A	uc001ttp.2	+	12	1821	c.1735G>A	c.(1735-1737)GAA>AAA	p.E579K	TRAFD1_uc001tto.2_Missense_Mutation_p.E579K	NM_006700	NP_006691	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	579	Poly-Glu.				negative regulation of innate immune response	intracellular	protein binding|zinc ion binding				0						TGCAGAAGAGGAAGAGGAGGA	0.493													14	72					0	0	0	0	A	112590581	A	A	112590581	3	1	8	1	0	0	0	0	1	0	0	0	16514	1175	41	2	1777	2	TRAFD1	12	112590581	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2960855	112590581	21261314	408	2297											
C12orf51	283450	broad.mit.edu	37	chr12	112699141	112699141	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgctatgtcactatttatGagggcagttgtgacctgctg	7	15	11	8	0	2	2	1	2	1	0	2	2	2	2	1	1	2	4	1	1	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:112699141G>A	uc009zwc.2	-	11	1563	c.1545C>T	c.(1543-1545)CTC>CTT	p.L515L	C12orf51_uc010syk.1_Silent_p.L338L|C12orf51_uc001tts.2_Silent_p.L338L|C12orf51_uc001ttt.3_Silent_p.L336L	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CACTATTTATGAGGGCAGTTG	0.458													19	55					0	0	0	0	A	112699141	A	A	112699141	2	1	8	1	0	0	0	0	0	0	0	1	1702	1277	45	2		2	C12orf51	12	112699141	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	108560	112699141	21152754	409	2298											
C12orf49	79794	broad.mit.edu	37	chr12	117175661	117175661	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagggcgagcacccacctCttccgcagaagccggcgcca	9	3	11	18	4	1	1	0	0	1	1	2	2	2	1	6	2	2	2	6	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:117175661C>G	uc001tvz.1	-	1	183	c.45G>C	c.(43-45)AAG>AAC	p.K15N	RNFT2_uc009zwn.2_5'Flank|RNFT2_uc001twb.3_5'Flank|RNFT2_uc001twa.3_5'Flank|C12orf49_uc009zwm.1_Missense_Mutation_p.E38Q	NM_024738	NP_079014	Q9H741	CL049_HUMAN	hypothetical protein LOC79794 precursor	15						extracellular region				ovary(1)	1	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0281)		GCACCCACCTCTTCCGCAGAA	0.592													12	24					0	0	0	0	G	117175661	G	G	117175661	3	3	8	1	0	0	0	0	1	0	0	0	1699	912	32	2	592	2	C12orf49	12	117175661	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4476520	117175661	16676234	410	2299											
C12orf43	64897	broad.mit.edu	37	chr12	121448689	121448689	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggaattcaggggtggtctGaagctcgttgccatcttgtt	6	14	13	8	2	3	1	1	1	2	0	5	2	3	2	1	4	2	3	1	4	2	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:121448689G>A	uc001tzh.1	-	3	252	c.229C>T	c.(229-231)CAG>TAG	p.Q77*	C12orf43_uc009zxa.1_Nonsense_Mutation_p.Q108*|C12orf43_uc010szo.1_Nonsense_Mutation_p.Q35*|C12orf43_uc010szp.1_Nonsense_Mutation_p.Q77*|C12orf43_uc001tzi.1_Nonsense_Mutation_p.Q77*	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	77											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGGGTGGTCTGAAGCTCGTTG	0.418													50	95					0	0	0	0	A	121448689	A	A	121448689	4	1	8	1	0	0	0	0	0	1	0	0	1695	1299	45	2	575	2	C12orf43	12	121448689	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4273028	121448689	12403206	411	2300											
ZCCHC8	55596	broad.mit.edu	37	chr12	122962395	122962395	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggatgaaacctacctgaatcGagctccatgtcggcgggaga	11	7	13	10	3	0	3	0	2	0	1	3	6	1	4	3	3	3	1	3	3	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:122962395G>A	uc001ucn.2	-	13	1469	c.1338C>T	c.(1336-1338)CTC>CTT	p.L446L	ZCCHC8_uc001ucl.2_Silent_p.L57L|ZCCHC8_uc001ucm.2_Silent_p.L208L|ZCCHC8_uc009zxp.2_Silent_p.L208L|ZCCHC8_uc009zxq.2_Silent_p.L208L	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	446						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		TACCTGAATCGAGCTCCATGT	0.333													14	43					0	0	0	0	A	122962395	A	A	122962395	2	1	8	1	0	0	0	0	0	0	0	1	17661	1045	37	1		1	ZCCHC8	12	122962395	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1513706	122962395	10889500	412	2301											
ZCCHC8	55596	broad.mit.edu	37	chr12	122967208	122967208	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaatctttcatttggtgttCttcagaaccacaattgaaac	12	14	6	9	0	4	2	2	1	2	1	4	2	4	2	1	1	2	2	1	1	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:122967208C>G	uc001ucn.2	-	8	837	c.706G>C	c.(706-708)GAA>CAA	p.E236Q	ZCCHC8_uc001ucm.2_5'UTR|ZCCHC8_uc009zxp.2_5'UTR|ZCCHC8_uc009zxq.2_5'UTR	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	236	CCHC-type.					catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		ATTTGGTGTTCTTCAGAACCA	0.289													14	44					0	0	0	0	G	122967208	G	G	122967208	3	3	8	1	0	0	0	0	1	0	0	0	17661	922	32	2	1445	2	ZCCHC8	12	122967208	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	4813	122967208	10884687	413	2302											
KNTC1	9735	broad.mit.edu	37	chr12	123014683	123014683	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagtgtcggttcaagaaaaGaacatggaactgctttatat	14	12	10	5	1	1	3	1	1	0	2	2	4	1	4	0	2	3	2	0	2	7	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:123014683G>C	uc001ucv.2	+	2	236	c.73G>C	c.(73-75)GAA>CAA	p.E25Q	KNTC1_uc010taf.1_Missense_Mutation_p.E25Q	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	25					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTCAAGAAAAGAACATGGAAC	0.383													34	113					0	0	0	0	C	123014683	C	C	123014683	3	2	8	1	0	0	0	0	1	0	0	0	8467	943	33	2	75	2	KNTC1	12	123014683	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	47475	123014683	10837212	414	2303											
SBNO1	55206	broad.mit.edu	37	chr12	123782660	123782660	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acataatacataatatgtacGgcaacgaagacctatttcac	17	10	5	9	2	1	1	1	0	0	1	1	2	1	1	1	1	3	2	1	1	8	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:123782660G>A	uc010tap.1	-	30	3904	c.3904C>T	c.(3904-3906)CGT>TGT	p.R1302C	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.R1301C|SBNO1_uc010taq.1_Missense_Mutation_p.R253C	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1302							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TAATATGTACGGCAACGAAGA	0.413													35	78					0	0	0	0	A	123782660	A	A	123782660	3	1	8	1	0	0	0	0	1	0	0	0	13927	1116	39	1	285	1	SBNO1	12	123782660	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	767977	123782660	10069235	415	2304											
SBNO1	55206	broad.mit.edu	37	chr12	123810857	123810857	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcagatctgcagcttgctGaaaccgctctctggcgatga	10	10	10	11	2	3	3	1	2	2	1	4	4	3	3	1	1	4	4	1	1	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:123810857G>A	uc010tap.1	-	13	1717	c.1717C>T	c.(1717-1719)CAG>TAG	p.Q573*	SBNO1_uc010tao.1_Nonsense_Mutation_p.Q572*|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Nonsense_Mutation_p.Q573*|SBNO1_uc001ueu.2_Nonsense_Mutation_p.Q572*|SBNO1_uc001uev.2_Nonsense_Mutation_p.Q571*|SBNO1_uc009zxy.1_Nonsense_Mutation_p.Q538*	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	573							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GCAGCTTGCTGAAACCGCTCT	0.403													20	175					0	0	0	0	A	123810857	A	A	123810857	4	1	8	1	0	0	0	0	0	1	0	0	13927	1299	45	2	2540	2	SBNO1	12	123810857	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	28197	123810857	10041038	416	2305											
GJB6	10804	broad.mit.edu	37	chr13	20797248	20797248	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacccctctatccgaaccttCtgctttttaatgtcctctat	7	16	4	14	1	3	0	0	0	3	0	5	2	5	0	5	0	2	1	5	0	4	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:20797248C>T	uc001umz.3	-	3	925	c.372G>A	c.(370-372)CAG>CAA	p.Q124Q	GJB6_uc001unc.3_Silent_p.Q124Q|GJB6_uc001una.3_Silent_p.Q124Q|GJB6_uc001und.3_Silent_p.Q124Q|GJB6_uc001unb.3_Silent_p.Q124Q	NM_006783	NP_006774	O95452	CXB6_HUMAN	gap junction protein, beta 6	124	Cytoplasmic (Potential).			Q -> H (in Ref. 1; CAA06611).	cell communication|sensory perception of sound	connexon complex|integral to membrane|intracellular membrane-bounded organelle				ovary(1)	1		all_cancers(29;2.04e-22)|all_epithelial(30;1.19e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;2.17e-05)|Epithelial(112;0.00075)|OV - Ovarian serous cystadenocarcinoma(117;0.00978)|Lung(94;0.0238)|GBM - Glioblastoma multiforme(144;0.0323)|LUSC - Lung squamous cell carcinoma(192;0.0744)		TCCGAACCTTCTGCTTTTTAA	0.463													15	48					0	0	0	0	T	20797248	T	T	20797248	2	4	8	1	0	0	0	0	0	0	0	1	6449	912	32	2		2	GJB6	13	20797248	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08		20797248	94372630	417	2306											
FLT1	2321	broad.mit.edu	37	chr13	29001376	29001376	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataccatatgcggtacaagtCaggatttgtctgctgcccag	10	11	10	10	1	2	0	1	0	1	0	2	1	2	1	2	2	5	2	2	2	4	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:29001376C>A	uc001usb.3	-	10	1641	c.1356G>T	c.(1354-1356)CTG>CTT	p.L452L	FLT1_uc010aar.1_Silent_p.L452L|FLT1_uc001usc.3_Silent_p.L452L|FLT1_uc010tdp.1_Silent_p.L452L	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	452	Ig-like C2-type 5.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CGGTACAAGTCAGGATTTGTC	0.488													18	61					9.16793e-09	9.5718e-09	1	0	A	29001376	A	A	29001376	2	1	8	1	0	0	0	0	0	0	0	1	5973	813	29	2		2	FLT1	13	29001376	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	8204128	29001376	86168502	418	2307											
KATNAL1	84056	broad.mit.edu	37	chr13	30804674	30804674	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcatcagaggttcctcttcGactgcagatagaatctatct	10	14	7	10	1	5	3	2	0	3	3	7	4	6	3	1	1	1	2	1	1	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:30804674G>A	uc001uss.2	-	8	1044	c.943C>T	c.(943-945)CGA>TGA	p.R315*	KATNAL1_uc001ust.2_Nonsense_Mutation_p.R315*	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	315						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		GTTCCTCTTCGACTGCAGATA	0.348													6	40					0	0	0	0	A	30804674	A	A	30804674	4	1	8	1	0	0	0	0	0	1	0	0	8024	1066	37	1	545	1	KATNAL1	13	30804674	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1803298	30804674	84365204	419	2308											
POSTN	10631	broad.mit.edu	37	chr13	38154776	38154776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctcgcggaatatgtgaatcGcaccgtttctcccttgctta	7	14	8	12	4	2	1	0	1	2	0	5	2	2	2	2	1	1	3	2	1	4	4	rs145787730	byFrequency	TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:38154776G>A	uc001uwo.3	-	11	1569	c.1451C>T	c.(1450-1452)GCG>GTG	p.A484V	POSTN_uc010tet.1_Missense_Mutation_p.A12V|POSTN_uc001uwp.3_Missense_Mutation_p.A484V|POSTN_uc001uwr.2_Missense_Mutation_p.A484V|POSTN_uc001uwq.2_Missense_Mutation_p.A484V|POSTN_uc010teu.1_Missense_Mutation_p.A484V|POSTN_uc010tev.1_Missense_Mutation_p.A484V|POSTN_uc010tew.1_Missense_Mutation_p.A484V|POSTN_uc010tex.1_Missense_Mutation_p.A399V	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	484	FAS1 3.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TATGTGAATCGCACCGTTTCT	0.443													22	145					0	0	0	0	A	38154776	A	A	38154776	3	1	8	1	0	0	0	0	1	0	0	0	12314	1087	38	1	1111	1	POSTN	13	38154776	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	7350102	38154776	77015102	420	2309											
FREM2	341640	broad.mit.edu	37	chr13	39450265	39450265	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaccagccagtacagcagtgGagctttgtctctgactttgc	9	11	10	11	0	1	1	0	1	1	0	2	2	1	2	2	1	6	3	2	1	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:39450265G>C	uc001uwv.2	+	19	8697	c.8388G>C	c.(8386-8388)TGG>TGC	p.W2796C		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2796	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TACAGCAGTGGAGCTTTGTCT	0.418													27	150					0	0	0	0	C	39450265	C	C	39450265	3	2	8	1	0	0	0	0	1	0	0	0	6079	1183	41	2	8462	2	FREM2	13	39450265	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1295489	39450265	75719613	421	2310											
NAA16	79612	broad.mit.edu	37	chr13	41894879	41894879	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgttaccgaaatgccctCaaattagataaagataacct	18	10	5	8	1	1	2	1	0	0	2	1	3	1	2	3	0	3	1	3	0	8	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:41894879C>G	uc001uyf.2	+	4	645	c.321C>G	c.(319-321)CTC>CTG	p.L107L	NAA16_uc010tfg.1_RNA|NAA16_uc001uye.3_Silent_p.L107L|NAA16_uc001uyd.3_Silent_p.L107L	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	107	TPR 2.				N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						GAAATGCCCTCAAATTAGATA	0.358													3	71					0	0	0	0	G	41894879	G	G	41894879	2	3	8	1	0	0	0	0	0	0	0	1	10172	813	29	2		2	NAA16	13	41894879	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2444614	41894879	73274999	422	2311											
CPB2	1361	broad.mit.edu	37	chr13	46629983	46629983	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcttcactggctactagaGactggaagcaacaagatata	14	9	9	9	0	1	2	1	0	0	2	1	4	1	3	0	2	4	3	0	2	7	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:46629983G>C	uc001vaw.2	-	10	1068	c.1001C>G	c.(1000-1002)TCT>TGT	p.S334C	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Missense_Mutation_p.S297C	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	334					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		GGCTACTAGAGACTGGAAGCA	0.333													16	72					0	0	0	0	C	46629983	C	C	46629983	3	2	8	1	0	0	0	0	1	0	0	0	3812	956	33	2	278	2	CPB2	13	46629983	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4735104	46629983	68539895	423	2312											
RBM26	64062	broad.mit.edu	37	chr13	79911392	79911392	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcacctcgacctcttgaatGaattcctctgccccgaccag	8	10	7	16	2	2	2	0	2	2	0	4	4	3	2	6	0	2	1	6	0	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:79911392G>A	uc001vkz.2	-	19	2598	c.2584C>T	c.(2584-2586)CAT>TAT	p.H862Y	RBM26_uc001vky.2_Missense_Mutation_p.H833Y|RBM26_uc001vla.2_Missense_Mutation_p.H836Y|RBM26_uc010tia.1_Missense_Mutation_p.H217Y|RBM26_uc001vkx.2_Missense_Mutation_p.H572Y	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	860					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		CCTCTTGAATGAATTCCTCTG	0.547													4	100					0	0	0	0	A	79911392	A	A	79911392	3	1	8	1	0	0	0	0	1	0	0	0	13191	1290	45	2	461	2	RBM26	13	79911392	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	33281409	79911392	35258486	424	2313											
ABCC4	10257	broad.mit.edu	37	chr13	95858999	95858999	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagccaaattcatccctctGaggcaggaacttctcagaat	13	9	8	11	0	3	2	2	1	2	1	5	4	4	3	2	2	2	1	2	2	4	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:95858999G>A	uc001vmd.3	-	8	1067	c.948C>T	c.(946-948)CTC>CTT	p.L316L	ABCC4_uc010afk.2_Silent_p.L316L|ABCC4_uc001vme.2_Silent_p.L316L|ABCC4_uc010tih.1_Silent_p.L241L|ABCC4_uc001vmf.2_Silent_p.L273L|ABCC4_uc010afl.1_Silent_p.L273L|ABCC4_uc010afm.1_Silent_p.L329L	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	316	ABC transmembrane type-1 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TCATCCCTCTGAGGCAGGAAC	0.413													21	220					0	0	0	0	A	95858999	A	A	95858999	2	1	8	1	0	0	0	0	0	0	0	1	55	1277	45	2		2	ABCC4	13	95858999	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	15947607	95858999	19310879	425	2314											
RAP2A	5911	broad.mit.edu	37	chr13	98086811	98086811	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcgtgaccggcaccttcatCgagaaatacgaccccaccat	11	8	7	15	4	1	2	1	1	0	1	3	4	1	2	5	1	1	1	5	1	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:98086811C>T	uc001vnd.2	+	1	337	c.87C>T	c.(85-87)ATC>ATT	p.I29I		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	29					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			GCACCTTCATCGAGAAATACG	0.607													18	90					0	0	0	0	T	98086811	T	T	98086811	2	4	8	1	0	0	0	0	0	0	0	1	13105	874	31	1		1	RAP2A	13	98086811	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2227812	98086811	17083067	426	2315											
TM9SF2	9375	broad.mit.edu	37	chr13	100204467	100204467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaatctgatcctctggggaGaaggatcttcagcagctatt	10	12	11	8	0	4	3	1	2	3	1	5	5	5	4	1	3	2	2	1	3	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:100204467G>A	uc001voj.1	+	13	1508	c.1375G>A	c.(1375-1377)GAA>AAA	p.E459K	TM9SF2_uc010afz.1_Missense_Mutation_p.E294K	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	459	Lumenal (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					CCTCTGGGGAGAAGGATCTTC	0.423													22	132					0	0	0	0	A	100204467	A	A	100204467	3	1	8	1	0	0	0	0	1	0	0	0	16044	943	33	2	1425	2	TM9SF2	13	100204467	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2117656	100204467	14965411	427	2316											
PCCA	5095	broad.mit.edu	37	chr13	100764110	100764110	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcagacttttgataaaattCttgttgctaatagaggagaa	14	15	8	4	0	2	4	1	1	1	3	2	5	2	4	0	1	1	2	0	1	5	9			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:100764110C>G	uc001voo.2	+	3	237	c.199C>G	c.(199-201)CTT>GTT	p.L67V	PCCA_uc010aga.2_Missense_Mutation_p.L41V|PCCA_uc010tiz.1_Missense_Mutation_p.L67V	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	67	Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	TGATAAAATTCTTGTTGCTAA	0.303													9	24					0	0	0	0	G	100764110	G	G	100764110	3	3	8	1	0	0	0	0	1	0	0	0	11558	913	32	2	209	2	PCCA	13	100764110	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	559643	100764110	14405768	428	2317											
RBM23	55147	broad.mit.edu	37	chr14	23371581	23371581	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcccgccgggcacactcaGaatcagagaactatgagaaa	14	4	12	11	2	2	3	2	1	0	3	2	5	2	3	2	2	1	1	2	2	4	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:23371581G>T	uc001whg.2	-	11	1140	c.941C>A	c.(940-942)TCT>TAT	p.S314Y	RBM23_uc001whh.2_Missense_Mutation_p.S298Y|RBM23_uc001whi.2_Missense_Mutation_p.S280Y|RBM23_uc010tne.1_Missense_Mutation_p.S144Y|RBM23_uc001whj.2_Missense_Mutation_p.S64Y	NM_001077351	NP_001070819	Q86U06	RBM23_HUMAN	RNA binding motif protein 23 isoform 1	314	RRM 2.				mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		GGCACACTCAGAATCAGAGAA	0.532													15	35					3.45872e-05	3.54344e-05	1	0	T	23371581	T	T	23371581	3	4	8	1	0	0	0	0	1	0	0	0	13188	942	33	2	394	2	RBM23	14	23371581	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08		23371581	83977959	429	2318											
MYH7	4625	broad.mit.edu	37	chr14	23884362	23884362	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccttgagggcgatctgctCggcttcgtccagccggtgct	3	10	14	14	4	1	1	0	1	1	0	4	2	2	1	3	3	3	3	3	3	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:23884362C>A	uc001wjx.2	-	37	5507	c.5401G>T	c.(5401-5403)GAG>TAG	p.E1801*		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1801	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCGATCTGCTCGGCTTCGTCC	0.622													15	103					1.3612e-06	1.41081e-06	1	0	A	23884362	A	A	23884362	4	1	8	1	0	0	0	0	0	1	0	0	10092	893	31	3	422	3	MYH7	14	23884362	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	512781	23884362	83465178	430	2319											
PSME1	5720	broad.mit.edu	37	chr14	24606752	24606752	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagacaaggatgaaaagaaGaagggggaggatgaagacaa	21	2	16	2	0	0	6	0	2	0	4	0	10	0	9	0	4	0	0	0	4	8	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:24606752G>C	uc001wmg.2	+	5	364	c.270G>C	c.(268-270)AAG>AAC	p.K90N	PSME1_uc001wmh.2_Missense_Mutation_p.K90N	NM_006263	NP_006254	Q06323	PSME1_HUMAN	proteasome activator subunit 1 isoform 1	90					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|proteasome activator complex				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00831)		ATGAAAAGAAGAAGGGGGAGG	0.483													12	64					0	0	0	0	C	24606752	C	C	24606752	3	2	8	1	0	0	0	0	1	0	0	0	12768	933	33	2	288	2	PSME1	14	24606752	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	722390	24606752	82742788	431	2320											
RNF31	55072	broad.mit.edu	37	chr14	24618025	24618025	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcagatgctgcagctttcaGaatttgaccccctattgaga	10	13	8	10	0	2	4	2	2	0	3	2	5	2	4	2	0	3	3	2	0	2	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:24618025G>C	uc001wmn.1	+	5	820	c.571G>C	c.(571-573)GAA>CAA	p.E191Q	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_Missense_Mutation_p.E40Q|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.E6Q|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	191	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GCAGCTTTCAGAATTTGACCC	0.483													47	240					0	0	0	0	C	24618025	C	C	24618025	3	2	8	1	0	0	0	0	1	0	0	0	13552	943	33	2	589	2	RNF31	14	24618025	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	11273	24618025	82731515	432	2321											
LTB4R	1241	broad.mit.edu	37	chr14	24785338	24785338	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtaccgcacagtagtgcccTggaaaacgaacatgagcctg	12	6	11	12	3	0	1	0	1	0	0	0	3	0	2	3	1	5	3	3	1	5	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:24785338T>C	uc001wos.2	+	2	802	c.481T>C	c.(481-483)TGG>CGG	p.W161R	LTB4R_uc010alp.2_Missense_Mutation_p.W161R|LTB4R_uc001wou.2_Missense_Mutation_p.W161R	NM_001143919	NP_001137391	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	161	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding				0				GBM - Glioblastoma multiforme(265;0.018)		AGTAGTGCCCTGGAAAACGAA	0.637													3	119					0	0	0	0	C	24785338	C	C	24785338	3	2	8	1	0	0	0	0	1	0	0	0	9121	1580	55	5	483	5	LTB4R	14	24785338	Missense_Mutation	SNP	T	TCGA-BA-5152-01A-02D-1870-08	167313	24785338	82564202	433	2322											
KIAA0391	9692	broad.mit.edu	37	chr14	35593114	35593114	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttctcatccggggattgatCcattcagacagatggagaga	11	10	11	9	1	2	4	2	1	1	3	5	7	4	6	2	3	0	0	2	3	0	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:35593114C>T	uc001wsy.1	+	2	1023	c.663C>T	c.(661-663)ATC>ATT	p.I221I	KIAA0391_uc010tps.1_Silent_p.I126I|KIAA0391_uc001wsz.1_Silent_p.I221I|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Silent_p.I221I|KIAA0391_uc001wtc.1_Intron|PPP2R3C_uc001wss.2_5'Flank|PPP2R3C_uc001wst.2_5'Flank|PPP2R3C_uc010tpr.1_5'Flank|PPP2R3C_uc001wsu.2_5'Flank|PPP2R3C_uc010amn.1_5'Flank|PPP2R3C_uc001wsw.2_5'Flank|PPP2R3C_uc001wsx.1_5'Flank	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	221					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		GGGGATTGATCCATTCAGACA	0.373													17	35					0	0	0	0	T	35593114	T	T	35593114	2	4	8	1	0	0	0	0	0	0	0	1	8211	845	30	2		2	KIAA0391	14	35593114	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	10807776	35593114	71756426	434	2323											
FSCB	84075	broad.mit.edu	37	chr14	44974621	44974621	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgctagaagctgaatttCagcagaggcctcttctgcag	10	10	11	10	0	3	3	1	1	2	2	3	3	3	3	1	1	5	5	1	1	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:44974621C>T	uc001wvn.2	-	1	1879	c.1570G>A	c.(1570-1572)GAA>AAA	p.E524K		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	524	Ala-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		AGCTGAATTTCAGCAGAGGCC	0.507													5	35					0	0	0	0	T	44974621	T	T	44974621	3	4	8	1	0	0	0	0	1	0	0	0	6100	835	29	2	911	2	FSCB	14	44974621	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	9381507	44974621	62374919	435	2324											
KLHL28	54813	broad.mit.edu	37	chr14	45414609	45414609	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caagtcagcatgtgtaagctCaaaaaactcttcagtctggc	13	10	8	10	0	5	0	3	0	2	0	5	0	5	0	0	1	3	3	0	1	5	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:45414609C>G	uc001wvq.2	-	2	769	c.523G>C	c.(523-525)GAG>CAG	p.E175Q	KLHL28_uc001wvr.2_Missense_Mutation_p.E175Q|KLHL28_uc001wvt.3_Missense_Mutation_p.E175Q	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	175										ovary(1)	1						TGTGTAAGCTCAAAAAACTCT	0.383													4	103					0	0	0	0	G	45414609	G	G	45414609	3	3	8	1	0	0	0	0	1	0	0	0	8421	835	29	2	1208	2	KLHL28	14	45414609	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	439988	45414609	61934931	436	2325											
C14orf101	54916	broad.mit.edu	37	chr14	57082694	57082694	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatatgaggaccgaactctCattcaacatccaagcccttg	14	9	6	12	1	2	1	2	1	1	0	4	3	3	2	3	1	3	0	3	1	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:57082694C>A	uc001xcm.2	+	8	1012	c.890C>A	c.(889-891)TCA>TAA	p.S297*	C14orf101_uc001xcj.2_RNA|C14orf101_uc010aot.1_Nonsense_Mutation_p.S297*|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_5'UTR|C14orf101_uc001xco.2_5'UTR	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	297						integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		ACCGAACTCTCATTCAACATC	0.313													38	123					6.68952e-21	7.18467e-21	1	0	A	57082694	A	A	57082694	4	1	8	1	0	0	0	0	0	1	0	0	1740	838	29	2	920	2	C14orf101	14	57082694	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	11668085	57082694	50266846	437	2326											
EXOC5	10640	broad.mit.edu	37	chr14	57699411	57699411	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacagatcatagagatttttGagatattgctctgcatcgga	12	14	9	6	1	2	3	1	1	1	3	3	6	2	4	0	1	3	2	0	1	3	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:57699411G>C	uc001xct.2	-	10	1163	c.912C>G	c.(910-912)CTC>CTG	p.L304L	EXOC5_uc001xcs.2_5'Flank|EXOC5_uc010trg.1_Silent_p.L249L|EXOC5_uc010trh.1_Silent_p.L239L	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein	304					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3						AGAGATTTTTGAGATATTGCT	0.254													3	55					0	0	0	0	C	57699411	C	C	57699411	2	2	8	1	0	0	0	0	0	0	0	1	5331	1277	45	2		2	EXOC5	14	57699411	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	616717	57699411	49650129	438	2327											
SPTB	6710	broad.mit.edu	37	chr14	65259779	65259779	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	catctcggccagccacttctCcttctctcccatccacagct	6	11	4	20	1	3	0	0	0	3	0	8	0	5	0	5	1	2	1	5	1	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:65259779C>G	uc001xht.2	-	13	2656	c.2602G>C	c.(2602-2604)GAG>CAG	p.E868Q	SPTB_uc001xhr.2_Missense_Mutation_p.E868Q|SPTB_uc001xhs.2_Missense_Mutation_p.E868Q|SPTB_uc001xhu.2_Missense_Mutation_p.E868Q	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	868	Spectrin 6.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		AGCCACTTCTCCTTCTCTCCC	0.602													19	44					0	0	0	0	G	65259779	G	G	65259779	3	3	8	1	0	0	0	0	1	0	0	0	15184	864	30	2	4545	2	SPTB	14	65259779	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7560368	65259779	42089761	439	2328											
SERPINA9	327657	broad.mit.edu	37	chr14	94935785	94935785	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgaagagggcacttcccatCttcaaggtcaggtctttgct	9	11	10	11	1	4	1	2	0	2	1	5	2	5	1	1	3	1	2	1	3	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:94935785C>G	uc001ydf.2	-	2	608	c.447G>C	c.(445-447)AAG>AAC	p.K149N	SERPINA9_uc001yde.2_Intron|SERPINA9_uc010avc.2_5'UTR|SERPINA9_uc001ydg.2_Missense_Mutation_p.K113N|SERPINA9_uc001ydh.1_Missense_Mutation_p.K149N|SERPINA9_uc001ydi.1_Missense_Mutation_p.K113N	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	131					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CACTTCCCATCTTCAAGGTCA	0.512													30	153					0	0	0	0	G	94935785	G	G	94935785	3	3	8	1	0	0	0	0	1	0	0	0	14160	912	32	2	876	2	SERPINA9	14	94935785	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	29676006	94935785	12413755	440	2329											
MKRN3	7681	broad.mit.edu	37	chr15	23811327	23811327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccactgagggtggcgtttCgccgcctggggcctctgcag	3	8	17	13	3	1	1	0	1	1	0	2	1	1	1	4	5	1	2	4	5	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:23811327C>T	uc001ywh.3	+	1	874	c.398C>T	c.(397-399)TCG>TTG	p.S133L	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.S133L	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	133						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GGTGGCGTTTCGCCGCCTGGG	0.627													15	61					0	0	0	0	T	23811327	T	T	23811327	3	4	8	1	0	0	0	0	1	0	0	0	9661	893	31	1	400	1	MKRN3	15	23811327	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		23811327	78720065	441	2330											
MTMR15	22909	broad.mit.edu	37	chr15	31220836	31220836	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcttcatggatgggattccgGatgtcttcagaaacgcctgt	8	13	11	9	2	4	1	2	0	2	1	5	4	5	4	2	3	1	0	2	3	1	3	rs139319999		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:31220836G>A	uc001zff.2	+	11	2860	c.2569G>A	c.(2569-2571)GAT>AAT	p.D857N	MTMR15_uc001zfe.2_Missense_Mutation_p.D462N	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	857					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		TGGGATTCCGGATGTCTTCAG	0.557								Direct_reversal_of_damage|Editing_and_processing_nucleases					22	135					0	0	0	0	A	31220836	A	A	31220836	3	1	8	1	0	0	0	0	1	0	0	0	9996	1174	41	2	2632	2	MTMR15	15	31220836	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	7409509	31220836	71310556	442	2331											
EIF2AK4	440275	broad.mit.edu	37	chr15	40257961	40257961	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggctttgtcttgttgtatGagtgggtccttcagtggcag	4	16	15	6	0	2	1	1	1	1	0	3	1	3	1	1	3	0	4	1	3	1	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:40257961G>C	uc001zkm.1	+	8	984	c.934G>C	c.(934-936)GAG>CAG	p.E312Q	EIF2AK4_uc001zkl.2_Missense_Mutation_p.E312Q|EIF2AK4_uc010bbj.1_Missense_Mutation_p.E41Q	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	312	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CTTGTTGTATGAGTGGGTCCT	0.408													16	63					0	0	0	0	C	40257961	C	C	40257961	3	2	8	1	0	0	0	0	1	0	0	0	5021	1291	45	2	964	2	EIF2AK4	15	40257961	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	9037125	40257961	62273431	443	2332											
GANC	2595	broad.mit.edu	37	chr15	42632913	42632913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgggtagagttccctgatGaactaaagacttttgatatg	11	14	11	5	0	0	5	0	3	0	2	1	5	1	5	1	1	1	2	1	1	5	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:42632913G>A	uc001zpi.2	+	18	2427	c.2113G>A	c.(2113-2115)GAA>AAA	p.E705K		NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	705					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GTTCCCTGATGAACTAAAGAC	0.239													23	71					0	0	0	0	A	42632913	A	A	42632913	3	1	8	1	0	0	0	0	1	0	0	0	6269	1291	45	2	2183	2	GANC	15	42632913	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2374952	42632913	59898479	444	2333											
LCMT2	9836	broad.mit.edu	37	chr15	43620956	43620956	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtaatgggaggctggatgtCtactgactcccagaggaatc	10	9	14	8	0	1	2	0	1	1	1	3	5	2	5	1	5	1	2	1	5	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:43620956C>T	uc001zrg.2	-	1	1936	c.1732G>A	c.(1732-1734)GAC>AAC	p.D578N	LCMT2_uc010udn.1_Missense_Mutation_p.D157N|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	578					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	GGCTGGATGTCTACTGACTCC	0.517													35	81					0	0	0	0	T	43620956	T	T	43620956	3	4	8	1	0	0	0	0	1	0	0	0	8719	913	32	2	332	2	LCMT2	15	43620956	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	988043	43620956	58910436	445	2334											
LCMT2	9836	broad.mit.edu	37	chr15	43621022	43621022	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagagttcaatggctcctCagaagccccgagacctccag	11	6	9	15	1	2	3	2	0	0	3	4	4	4	3	5	1	1	2	5	1	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:43621022C>G	uc001zrg.2	-	1	1870	c.1666G>C	c.(1666-1668)GAG>CAG	p.E556Q	LCMT2_uc010udn.1_Missense_Mutation_p.E135Q|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	556					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	AATGGCTCCTCAGAAGCCCCG	0.557													9	121					0	0	0	0	G	43621022	G	G	43621022	3	3	8	1	0	0	0	0	1	0	0	0	8719	835	29	2	398	2	LCMT2	15	43621022	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	66	43621022	58910370	446	2335											
ZSCAN29	146050	broad.mit.edu	37	chr15	43653641	43653641	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacattgataaggtttctctCctgtgtggattctcctatgg	7	16	9	9	0	2	1	0	1	2	0	5	2	3	2	2	3	0	1	2	3	2	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:43653641C>T	uc001zrk.1	-	5	2336	c.2189G>A	c.(2188-2190)GGA>GAA	p.G730E	ZSCAN29_uc001zrj.1_Missense_Mutation_p.G610E|ZSCAN29_uc010bdf.1_3'UTR|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Missense_Mutation_p.G340E	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	730					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		AGGTTTCTCTCCTGTGTGGAT	0.433													15	59					0	0	0	0	T	43653641	T	T	43653641	3	4	8	1	0	0	0	0	1	0	0	0	18303	855	30	2	373	2	ZSCAN29	15	43653641	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	32619	43653641	58877751	447	2336											
DUOXA1	90527	broad.mit.edu	37	chr15	45415129	45415129	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgcagtcagaaagatcatGatgatgctggccaaagtggt	13	9	13	6	0	2	4	2	2	0	2	2	4	2	4	1	2	2	2	1	2	2	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:45415129G>A	uc001zuq.1	-	1	113	c.84C>T	c.(82-84)ATC>ATT	p.I28I	DUOXA1_uc010uem.1_Silent_p.I28I|DUOXA1_uc001zup.2_Silent_p.I28I|DUOXA1_uc010bec.2_Silent_p.I28I|DUOXA1_uc001zur.1_Silent_p.I28I|DUOXA1_uc010bed.1_Silent_p.I28I	NM_144565	NP_653166	Q1HG43	DOXA1_HUMAN	Numb-interacting protein	28	Helical; (Potential).				protein transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		GAAAGATCATGATGATGCTGG	0.562													30	62					0	0	0	0	A	45415129	A	A	45415129	2	1	8	1	0	0	0	0	0	0	0	1	4824	1280	45	2		2	DUOXA1	15	45415129	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1761488	45415129	57116263	448	2337											
SPATA5L1	79029	broad.mit.edu	37	chr15	45695714	45695714	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcccgggagatttgaccgaGaggtgaatgggcttggcggg	7	7	20	7	3	0	4	0	2	0	2	0	6	0	4	2	6	0	1	2	6	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:45695714G>C	uc001zve.2	+	1	1196	c.1087G>C	c.(1087-1089)GAG>CAG	p.E363Q	uc001zvd.2_5'Flank|SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	363						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		ATTTGACCGAGAGGTGAATGG	0.662													6	53					0	0	0	0	C	45695714	C	C	45695714	3	2	8	1	0	0	0	0	1	0	0	0	15078	943	33	2	1089	2	SPATA5L1	15	45695714	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	280585	45695714	56835678	449	2338											
USP50	373509	broad.mit.edu	37	chr15	50830917	50830917	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aatccatacctttttaggtgGaaaataattatttttggtgc	12	17	7	5	0	0	0	0	0	0	0	1	1	1	1	2	3	2	0	2	3	7	8			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:50830917G>A	uc001zyq.3	-	5	987	c.807C>T	c.(805-807)TTC>TTT	p.F269F		NM_203494	NP_987090	E9PP86	E9PP86_HUMAN	ubiquitin specific protease 50	264					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			lung(1)|breast(1)	2				all cancers(107;0.000519)|GBM - Glioblastoma multiforme(94;0.00288)		TTTTTAGGTGGAAAATAATTA	0.274													6	5					0	0	0	0	A	50830917	A	A	50830917	2	1	8	1	0	0	0	0	0	0	0	1	17150	1165	41	2		2	USP50	15	50830917	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5135203	50830917	51700475	450	2339											
LDHAL6B	92483	broad.mit.edu	37	chr15	59499805	59499805	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgctcgttttcgtttcttGattggacaaaagcttggtat	8	17	9	7	2	1	1	0	1	1	0	3	2	1	2	0	2	2	5	0	2	3	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:59499805G>C	uc002agb.2	+	1	764	c.666G>C	c.(664-666)TTG>TTC	p.L222F	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	222					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	TTCGTTTCTTGATTGGACAAA	0.438													16	72					0	0	0	0	C	59499805	C	C	59499805	3	2	8	1	0	0	0	0	1	0	0	0	8740	1281	45	2	668	2	LDHAL6B	15	59499805	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8668888	59499805	43031587	451	2340											
LDHAL6B	92483	broad.mit.edu	37	chr15	59499959	59499959	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taggaactgataaagatcctGagcaatggaaaaatgtccac	17	8	9	7	0	0	3	0	2	0	1	2	5	2	5	2	2	2	1	2	2	7	2	rs139039522		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:59499959G>C	uc002agb.2	+	1	918	c.820G>C	c.(820-822)GAG>CAG	p.E274Q	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	274					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	TAAAGATCCTGAGCAATGGAA	0.433													9	61					0	0	0	0	C	59499959	C	C	59499959	3	2	8	1	0	0	0	0	1	0	0	0	8740	1291	45	2	822	2	LDHAL6B	15	59499959	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	154	59499959	43031433	452	2341											
PDCD7	10081	broad.mit.edu	37	chr15	65412134	65412134	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttttctttgtttcttttCtaattctcttttcctctctt	2	28	1	10	0	6	0	0	0	6	0	9	0	7	0	1	0	0	1	1	0	1	12			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:65412134C>G	uc002aol.2	-	3	1223	c.1168G>C	c.(1168-1170)GAA>CAA	p.E390Q		NM_005707	NP_005698	Q8N8D1	PDCD7_HUMAN	programmed cell death 7	390	Potential.				apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex					0						tgtttcttttctaattctctt	0.274													12	55					0	0	0	0	G	65412134	G	G	65412134	3	3	8	1	0	0	0	0	1	0	0	0	11679	922	32	2	301	2	PDCD7	15	65412134	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5912175	65412134	37119258	453	2342											
MAP2K1	5604	broad.mit.edu	37	chr15	66781559	66781559	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acatgtgtttgcagcctcctCcaaaactgcccagtggagtg	9	10	10	12	0	0	0	0	0	0	0	2	1	2	1	4	1	4	2	4	1	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:66781559C>G	uc010bhq.2	+	9	1442	c.967C>G	c.(967-969)CCA>GCA	p.P323A	MAP2K1_uc010ujp.1_Missense_Mutation_p.P301A	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	323	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GCAGCCTCCTCCAAAACTGCC	0.483									Cardiofaciocutaneous_syndrome				18	60					0	0	0	0	G	66781559	G	G	66781559	3	3	8	1	0	0	0	0	1	0	0	0	9289	855	30	2	1001	2	MAP2K1	15	66781559	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1369425	66781559	35749833	454	2343											
KIF23	9493	broad.mit.edu	37	chr15	69733362	69733362	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtactggactgaaggcaggGaggtggttcctacattcaga	10	10	14	7	0	1	2	1	1	0	1	2	4	2	4	1	5	2	3	1	5	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:69733362G>C	uc002asb.2	+	18	2440	c.2323G>C	c.(2323-2325)GAG>CAG	p.E775Q	KIF23_uc002asc.2_Intron|KIF23_uc010bii.2_Missense_Mutation_p.E665Q|KIF23_uc010ukc.1_Intron	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	775					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						TGAAGGCAGGGAGGTGGTTCC	0.448													5	42					0	0	0	0	C	69733362	C	C	69733362	3	2	8	1	0	0	0	0	1	0	0	0	8330	1175	41	2	2393	2	KIF23	15	69733362	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2951803	69733362	32798030	455	2344											
PKM2	5315	broad.mit.edu	37	chr15	72499611	72499611	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcactggcctccaggatttCatcaaacctgatggacaaag	13	9	8	11	0	3	1	3	1	0	0	4	3	4	3	3	3	1	0	3	3	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:72499611C>T	uc002atx.1	-	7	1085	c.844G>A	c.(844-846)GAA>AAA	p.E282K	PKM2_uc002ats.1_5'Flank|PKM2_uc002att.1_Missense_Mutation_p.E48K|PKM2_uc002atu.1_Missense_Mutation_p.E48K|PKM2_uc010bit.1_Missense_Mutation_p.E287K|PKM2_uc010uki.1_Missense_Mutation_p.E356K|PKM2_uc002atv.1_Missense_Mutation_p.E317K|PKM2_uc002atw.1_Missense_Mutation_p.E282K|PKM2_uc002aty.1_Missense_Mutation_p.E282K|PKM2_uc010ukj.1_Missense_Mutation_p.E267K|PKM2_uc010ukk.1_Missense_Mutation_p.E208K|PKM2_uc010biu.1_Missense_Mutation_p.E303K|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	282					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	TCCAGGATTTCATCAAACCTG	0.478													15	46					0	0	0	0	T	72499611	T	T	72499611	3	4	8	1	0	0	0	0	1	0	0	0	12032	835	29	2	942	2	PKM2	15	72499611	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2766249	72499611	30031781	456	2345											
CELF6	60677	broad.mit.edu	37	chr15	72608214	72608214	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggtcttctgctcgtgcagtGcactctgggccttgagagca	5	11	14	11	1	3	1	0	1	3	1	4	2	3	1	1	2	4	4	1	2	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:72608214G>A	uc002auh.2	-	2	627	c.317C>T	c.(316-318)GCA>GTA	p.A106V	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010ukm.1_Missense_Mutation_p.A106V|CELF6_uc002aui.2_Silent_p.C228C|CELF6_uc002auj.2_5'UTR	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	106	RRM 1.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						CTCGTGCAGTGCACTCTGGGC	0.627													7	13					0	0	0	0	A	72608214	A	A	72608214	3	1	8	1	0	0	0	0	1	0	0	0	3235	1319	46	4	1172	4	CELF6	15	72608214	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	108603	72608214	29923178	457	2346											
TMEM202	338949	broad.mit.edu	37	chr15	72691140	72691140	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctgatcgccatgtccccActgaactgggtacagtttct	8	12	9	12	1	1	2	0	2	1	0	3	2	2	2	3	1	3	3	3	1	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:72691140A>G	uc002auq.2	+	2	228	c.228A>G	c.(226-228)CCA>CCG	p.P76P	TMEM202_uc002aur.2_Intron	NM_001080462	NP_001073931	A6NGA9	TM202_HUMAN	transmembrane protein 202	76						integral to membrane				central_nervous_system(1)|skin(1)	2						CCATGTCCCCACTGAACTGGG	0.527													26	56					0	0	0	0	G	72691140	G	G	72691140	2	3	8	1	0	0	0	0	0	0	0	1	16193	146	6	5		5	TMEM202	15	72691140	Silent	SNP	A	TCGA-BA-5152-01A-02D-1870-08	82926	72691140	29840252	458	2347											
STRA6	64220	broad.mit.edu	37	chr15	74477352	74477352	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtgagcgcatcaggaccaGgaaggtgagtaagcaggaca	14	4	15	8	1	1	2	1	2	0	0	1	5	1	5	1	4	2	3	1	4	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:74477352G>C	uc002axk.2	-	13	1317	c.1135C>G	c.(1135-1137)CTG>GTG	p.L379V	STRA6_uc002axi.2_Missense_Mutation_p.L188V|STRA6_uc010ulh.1_Missense_Mutation_p.L417V|STRA6_uc002axj.2_Missense_Mutation_p.L418V|STRA6_uc010bji.2_Missense_Mutation_p.L379V|STRA6_uc002axl.2_Missense_Mutation_p.L311V|STRA6_uc002axm.2_Missense_Mutation_p.L379V|STRA6_uc002axn.2_Missense_Mutation_p.L370V|STRA6_uc010uli.1_Missense_Mutation_p.L416V|STRA6_uc010bjj.1_RNA	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	379	Helical; (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						ATCAGGACCAGGAAGGTGAGT	0.597													10	36					0	0	0	0	C	74477352	C	C	74477352	3	2	8	1	0	0	0	0	1	0	0	0	15388	991	35	4	896	4	STRA6	15	74477352	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1786212	74477352	28054040	459	2348											
CYP1A2	1544	broad.mit.edu	37	chr15	75044189	75044189	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tacagaggaagatccagaagGagctgggtacatgggggccc	12	5	16	8	0	0	3	0	0	0	3	1	5	1	5	2	5	3	2	2	5	4	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:75044189G>C	uc002ayr.1	+	4	1100	c.1036G>C	c.(1036-1038)GAG>CAG	p.E346Q		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	346					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	GATCCAGAAGGAGCTGGGTAC	0.433													16	70					0	0	0	0	C	75044189	C	C	75044189	3	2	8	1	0	0	0	0	1	0	0	0	4167	1175	41	2	1046	2	CYP1A2	15	75044189	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	566837	75044189	27487203	460	2349											
CYP1A2	1544	broad.mit.edu	37	chr15	75047131	75047131	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcctctgttcctcttgcaGagagctgtgggaggacccct	5	12	11	13	0	3	1	0	0	3	1	5	4	4	3	4	2	2	3	4	2	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:75047131G>C	uc002ayr.1	+	7	1318	c.1254_splice	c.e7-1	p.P418_splice		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,						alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	TCCTCTTGCAGAGAGCTGTGG	0.592													18	112					0	0	0	0	C	75047131	C	C	75047131	5	2	8	1	0	0	0	0	0	0	1	0	4167	956	33	2	1275	2	CYP1A2	15	75047131	Splice_Site	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2942	75047131	27484261	461	2350											
LINGO1	84894	broad.mit.edu	37	chr15	77907918	77907918	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttgttgaaggcgccgggctCcacggcgctcacgatgttct	5	10	14	12	5	2	1	1	1	1	0	3	2	3	1	2	3	0	5	2	3	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:77907918C>A	uc002bct.1	-	2	383	c.331G>T	c.(331-333)GAG>TAG	p.E111*	LINGO1_uc002bcu.1_Nonsense_Mutation_p.E105*	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	111	Extracellular (Potential).|LRR 2.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						GCGCCGGGCTCCACGGCGCTC	0.617													6	10					5.9392e-07	6.17364e-07	1	0	A	77907918	A	A	77907918	4	1	8	1	0	0	0	0	0	1	0	0	8856	864	30	2	1535	2	LINGO1	15	77907918	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2860787	77907918	24623474	462	2351											
KIAA1199	57214	broad.mit.edu	37	chr15	81171075	81171075	+	Frame_Shift_Del	DEL	C	-	-																															ttggcagtggctgctgggtgCcctgaccagagccctgagtt																										TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:81171075delC	uc002bfw.1	+	3	368	c.108delC	c.(106-108)TGCfs	p.C36fs	KIAA1199_uc010unn.1_Frame_Shift_Del_p.C36fs	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	36										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTGCTGGGTGCCCTGACCAGA	0.582													---	---	---								-	81171075	-	-	81171075	7	5	8	1	0	1	0	1	0	0	0	0	8252	747	26	0	114	0	KIAA1199	15	81171075	Frame_Shift_Del	DEL	C	TCGA-BA-5152-01A-02D-1870-08	3263157	81171075	21360317	463	2352											
FAM154B	283726	broad.mit.edu	37	chr15	82575272	82575272	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtaaccatgtactctgtaGagtacacaccgaaaagacag	16	8	8	9	1	1	2	0	0	1	2	1	3	1	2	2	0	3	4	2	0	6	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:82575272G>C	uc002bgv.2	+	3	1135	c.1066G>C	c.(1066-1068)GAG>CAG	p.E356Q	FAM154B_uc010unr.1_Missense_Mutation_p.E341Q|FAM154B_uc010uns.1_RNA	NM_001008226	NP_001008227	Q658L1	F154B_HUMAN	hypothetical protein LOC283726	356										skin(2)	2						GTACTCTGTAGAGTACACACC	0.398													11	59					0	0	0	0	C	82575272	C	C	82575272	3	2	8	1	0	0	0	0	1	0	0	0	5492	943	33	2	1076	2	FAM154B	15	82575272	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1404197	82575272	19956120	464	2353											
BNC1	646	broad.mit.edu	37	chr15	83932315	83932315	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaggggcatgtcttcatctGagctgaggttgtgtcttttc	5	16	13	7	0	4	2	1	2	3	0	5	2	4	2	0	3	1	4	0	3	1	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:83932315G>A	uc002bjt.1	-	4	1776	c.1688C>T	c.(1687-1689)TCA>TTA	p.S563L	BNC1_uc010uos.1_Missense_Mutation_p.S551L	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	563					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						GTCTTCATCTGAGCTGAGGTT	0.478													25	174					0	0	0	0	A	83932315	A	A	83932315	3	1	8	1	0	0	0	0	1	0	0	0	1477	1294	45	2	1304	2	BNC1	15	83932315	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1357043	83932315	18599077	465	2354											
ISG20	3669	broad.mit.edu	37	chr15	89195491	89195491	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagctggaccactgcaggCgtgtctccctgcgggtgctg	5	8	14	14	2	1	0	0	0	1	0	2	1	1	1	3	3	4	3	3	3	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:89195491C>T	uc002bmv.1	+	3	672	c.379C>T	c.(379-381)CGT>TGT	p.R127C	ISG20_uc002bmu.1_RNA|ISG20_uc002bmw.1_RNA|ISG20_uc010upn.1_RNA	NM_002201	NP_002192	Q96AZ6	ISG20_HUMAN	interferon stimulated exonuclease	127					cell proliferation|DNA catabolic process, exonucleolytic|response to virus|RNA catabolic process|type I interferon-mediated signaling pathway	PML body	3'-5'-exoribonuclease activity|exoribonuclease II activity|metal ion binding|RNA binding|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity				0	Lung NSC(78;0.0554)|all_lung(78;0.103)		BRCA - Breast invasive adenocarcinoma(143;0.12)			CCACTGCAGGCGTGTCTCCCT	0.463													9	76					0	0	0	0	T	89195491	T	T	89195491	3	4	8	1	0	0	0	0	1	0	0	0	7893	768	27	1	385	1	ISG20	15	89195491	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5263176	89195491	13335901	466	2355											
WDR90	197335	broad.mit.edu	37	chr16	706411	706411	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gacacgctgtcccgggtgtaCcacatgctggctcgctccca	6	8	11	16	3	0	0	0	0	0	0	3	1	2	0	3	2	2	5	3	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:706411C>G	uc002cii.1	+	18	2130	c.2076C>G	c.(2074-2076)TAC>TAG	p.Y692*	WDR90_uc002cig.1_3'UTR|WDR90_uc002cih.1_3'UTR|WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Nonsense_Mutation_p.Y219*|WDR90_uc002cil.1_5'Flank|WDR90_uc002cim.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	692	WD 5.									ovary(1)	1		Hepatocellular(780;0.0218)				CCCGGGTGTACCACATGCTGG	0.697													5	19					0	0	0	0	G	706411	G	G	706411	4	3	8	1	0	0	0	0	0	1	0	0	17405	518	18	4	2146	4	WDR90	16	706411	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		706411	89648342	467	2356											
RPUSD1	113000	broad.mit.edu	37	chr16	836894	836894	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcccgtgttccagaaccacGagatctgtgaggcttggctt	8	10	12	11	2	1	3	0	1	1	2	2	4	2	3	3	2	2	3	3	2	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:836894G>A	uc002cka.2	-	4	678	c.444C>T	c.(442-444)CTC>CTT	p.L148L	RPUSD1_uc002ckb.2_Silent_p.L148L|RPUSD1_uc002ckc.2_Silent_p.L19L|RPUSD1_uc002ckd.2_Missense_Mutation_p.S114L|CHTF18_uc010uus.1_5'Flank|CHTF18_uc010bre.1_5'Flank|CHTF18_uc002cke.3_5'Flank|CHTF18_uc002ckf.3_5'Flank|CHTF18_uc010brf.2_5'Flank|CHTF18_uc002ckg.3_5'Flank	NM_058192	NP_478072	Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing	148					pseudouridine synthesis		pseudouridine synthase activity|RNA binding				0		Hepatocellular(780;0.00335)				CCAGAACCACGAGATCTGTGA	0.632													31	95					0	0	0	0	A	836894	A	A	836894	2	1	8	1	0	0	0	0	0	0	0	1	13731	1045	37	1		1	RPUSD1	16	836894	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	130483	836894	89517859	468	2357											
TBC1D24	57465	broad.mit.edu	37	chr16	2547031	2547031	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagcgttcgccatccgcctCttctcccgcaaggagatcca	9	8	8	16	4	2	1	0	0	2	1	6	2	4	1	5	1	1	2	5	1	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:2547031C>T	uc002cql.2	+	2	1022	c.882C>T	c.(880-882)CTC>CTT	p.L294L	TBC1D24_uc002cqk.2_Silent_p.L294L|TBC1D24_uc002cqm.2_Silent_p.L294L|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	294					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						CCATCCGCCTCTTCTCCCGCA	0.597													21	51					0	0	0	0	T	2547031	T	T	2547031	2	4	8	1	0	0	0	0	0	0	0	1	15680	900	32	2		2	TBC1D24	16	2547031	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1710137	2547031	87807722	469	2358											
ACSM2A	123876	broad.mit.edu	37	chr16	20487070	20487070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagacaggactggacatccGagaatcctatggccagacag	13	5	11	12	1	0	3	0	0	0	3	2	6	2	5	4	3	0	0	4	3	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:20487070G>A	uc010bwe.2	+	9	1312	c.1073G>A	c.(1072-1074)CGA>CAA	p.R358Q	ACSM2A_uc010vax.1_Missense_Mutation_p.R279Q|ACSM2A_uc002dhf.3_Missense_Mutation_p.R358Q|ACSM2A_uc002dhg.3_Missense_Mutation_p.R358Q|ACSM2A_uc010vay.1_Missense_Mutation_p.R279Q|ACSM2A_uc002dhh.3_5'UTR	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	358					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CTGGACATCCGAGAATCCTAT	0.493													27	245					0	0	0	0	A	20487070	A	A	20487070	3	1	8	1	0	0	0	0	1	0	0	0	183	1058	37	1	1099	1	ACSM2A	16	20487070	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	17940039	20487070	69867683	470	2359											
USP31	57478	broad.mit.edu	37	chr16	23113736	23113736	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtttccaggtcgtctgtatCacaaaaggaacgatggaacc	12	10	10	9	2	2	0	1	0	1	0	4	3	3	2	2	3	2	2	2	3	5	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:23113736C>G	uc002dll.2	-	6	1138	c.1138G>C	c.(1138-1140)GAT>CAT	p.D380H		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	380					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		TCGTCTGTATCACAAAAGGAA	0.383													29	70					0	0	0	0	G	23113736	G	G	23113736	3	3	8	1	0	0	0	0	1	0	0	0	17130	826	29	2	2964	2	USP31	16	23113736	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2626666	23113736	67241017	471	2360											
KCTD13	253980	broad.mit.edu	37	chr16	29934634	29934634	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacccatcccgcaggtaattGaggattgtaccaaagtgacg	12	8	11	10	2	0	2	0	2	0	0	1	4	1	3	3	2	1	3	3	2	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:29934634G>C	uc002duv.2	-	2	482	c.291C>G	c.(289-291)CTC>CTG	p.L97L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KCTD13_uc010vee.1_RNA	NM_178863	NP_849194	Q8WZ19	BACD1_HUMAN	potassium channel tetramerisation domain	97	BTB.				cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0						GCAGGTAATTGAGGATTGTAC	0.612													8	45					0	0	0	0	C	29934634	C	C	29934634	2	2	8	1	0	0	0	0	0	0	0	1	8139	1277	45	2		2	KCTD13	16	29934634	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	6820898	29934634	60420119	472	2361											
ZNF764	92595	broad.mit.edu	37	chr16	30569449	30569449	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agcccccggctccctccactCgggtccggccccgtttgggt	2	8	12	19	4	0	0	0	0	0	0	4	0	3	0	7	4	1	2	7	4	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:30569449C>G	uc002dyq.2	-	1	136	c.55G>C	c.(55-57)GAG>CAG	p.E19Q	ZNF764_uc002dyr.1_Missense_Mutation_p.E19Q	NM_033410	NP_219363	Q96H86	ZN764_HUMAN	zinc finger protein 764	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCCCTCCACTCGGGTCCGGCC	0.726													11	11					0	0	0	0	G	30569449	G	G	30569449	3	3	8	1	0	0	0	0	1	0	0	0	18205	893	31	3	1183	3	ZNF764	16	30569449	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	634815	30569449	59785304	473	2362											
ZNF629	23361	broad.mit.edu	37	chr16	30793399	30793399	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggaggacggaagagctCttccccagctctggactctt	8	9	11	13	1	3	1	0	0	3	1	5	5	5	5	3	4	2	2	3	4	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:30793399C>A	uc002dzs.1	-	3	2458	c.2250G>T	c.(2248-2250)AAG>AAT	p.K750N		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	750					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			CGGAAGAGCTCTTCCCCAGCT	0.617													36	100					6.05902e-23	6.52722e-23	1	0	A	30793399	A	A	30793399	3	1	8	1	0	0	0	0	1	0	0	0	18120	912	32	2	363	2	ZNF629	16	30793399	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	223950	30793399	59561354	474	2363											
STX4	6810	broad.mit.edu	37	chr16	31049870	31049870	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgactcgacaggccttaaatGagatctcggcccggcacagt	10	8	11	12	3	1	2	0	2	1	1	3	4	1	2	2	3	0	1	2	3	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:31049870G>A	uc002eal.2	+	8	828	c.604G>A	c.(604-606)GAG>AAG	p.E202K	STX4_uc002eak.2_Missense_Mutation_p.E200K|STX4_uc002eam.2_Missense_Mutation_p.E124K	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	202	Cytoplasmic (Potential).|Interaction with CENPF (By similarity).|t-SNARE coiled-coil homology.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						GGCCTTAAATGAGATCTCGGC	0.552													20	55					0	0	0	0	A	31049870	A	A	31049870	3	1	8	1	0	0	0	0	1	0	0	0	15413	1291	45	2	634	2	STX4	16	31049870	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	256471	31049870	59304883	475	2364											
PYCARD	29108	broad.mit.edu	37	chr16	31213912	31213912	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgggatgcgcccgtagccctCgcgcagcggcaccgacagca	7	3	14	17	7	0	0	0	0	0	0	1	2	0	1	3	2	4	4	3	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:31213912C>G	uc010cak.2	-	1	340	c.100G>C	c.(100-102)GAG>CAG	p.E34Q	PYCARD_uc002ebm.2_Missense_Mutation_p.E34Q	NM_013258	NP_037390	Q9ULZ3	ASC_HUMAN	PYD and CARD domain containing isoform a	34	DAPIN.				induction of apoptosis|positive regulation of interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex	caspase activator activity|cysteine-type endopeptidase activity|protein homodimerization activity|Pyrin domain binding				0						CCGTAGCCCTCGCGCAGCGGC	0.677													20	31					0	0	0	0	G	31213912	G	G	31213912	3	3	8	1	0	0	0	0	1	0	0	0	12919	893	31	3	499	3	PYCARD	16	31213912	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	164042	31213912	59140841	476	2365											
NKD1	85407	broad.mit.edu	37	chr16	50666202	50666202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgccgtaggttccagggtGacagccgcctggagcagtct	6	8	14	13	2	1	1	0	1	1	0	2	2	2	2	5	3	3	3	5	3	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:50666202G>A	uc002egg.1	+	9	930	c.706G>A	c.(706-708)GAC>AAC	p.D236N		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	236					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		GTTCCAGGGTGACAGCCGCCT	0.557													16	38					0	0	0	0	A	50666202	A	A	50666202	3	1	8	1	0	0	0	0	1	0	0	0	10495	1290	45	2	740	2	NKD1	16	50666202	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	19452290	50666202	39688551	477	2366											
CCDC135	84229	broad.mit.edu	37	chr16	57761225	57761225	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcaggtgctggagattctGaagcttcgagaggaagagga	11	10	15	5	1	2	4	1	1	1	3	3	8	2	6	0	4	2	2	0	4	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:57761225G>A	uc002emi.2	+	15	2189	c.2100G>A	c.(2098-2100)CTG>CTA	p.L700L	CCDC135_uc002emj.2_Silent_p.L700L|CCDC135_uc002emk.2_Silent_p.L635L	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	700	Potential.					cytoplasm				central_nervous_system(1)	1						TGGAGATTCTGAAGCTTCGAG	0.433													44	111					0	0	0	0	A	57761225	A	A	57761225	2	1	8	1	0	0	0	0	0	0	0	1	2781	1277	45	2		2	CCDC135	16	57761225	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	7095023	57761225	32593528	478	2367											
CES2	8824	broad.mit.edu	37	chr16	66975679	66975679	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctggccatccaggtcatgagGatctatgatacccagaagga	12	8	11	10	0	2	3	1	2	1	1	3	5	3	5	3	4	1	0	3	4	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:66975679G>A	uc002eqr.2	+	8	2257	c.1257G>A	c.(1255-1257)AGG>AGA	p.R419R	CES2_uc002eqq.2_Silent_p.R419R|CES2_uc002eqs.2_Silent_p.R262R	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	355					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		AGGTCATGAGGATCTATGATA	0.572													62	177					0	0	0	0	A	66975679	A	A	66975679	2	1	8	1	0	0	0	0	0	0	0	1	3285	1165	41	2		2	CES2	16	66975679	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	9214454	66975679	23379074	479	2368											
HSD11B2	3291	broad.mit.edu	37	chr16	67469873	67469873	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accccaggcctgtggggcctCgtcaacaacgcaggccacaa	10	4	11	16	2	1	0	1	0	0	0	2	0	1	0	5	4	2	1	5	4	3	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:67469873C>T	uc002etd.2	+	3	608	c.492C>T	c.(490-492)CTC>CTT	p.L164L		NM_000196	NP_000187	P80365	DHI2_HUMAN	hydroxysteroid (11-beta) dehydrogenase 2	164					glucocorticoid biosynthetic process	endoplasmic reticulum|microsome					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0401)|Epithelial(162;0.0891)	NADH(DB00157)	TGTGGGGCCTCGTCAACAACG	0.602													22	78					0	0	0	0	T	67469873	T	T	67469873	2	4	8	1	0	0	0	0	0	0	0	1	7416	871	31	1		1	HSD11B2	16	67469873	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	494194	67469873	22884880	480	2369											
NFATC3	4775	broad.mit.edu	37	chr16	68160439	68160439	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtgcaacctaaaactcatCatcgagcccattatgaaact	16	9	5	11	1	2	1	2	1	0	0	3	2	2	1	2	0	5	1	2	0	6	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:68160439C>T	uc002evo.1	+	3	1537	c.1327C>T	c.(1327-1329)CAT>TAT	p.H443Y	NFATC3_uc010vkl.1_5'UTR|NFATC3_uc010vkm.1_5'UTR|NFATC3_uc010vkn.1_5'UTR|NFATC3_uc010vko.1_5'UTR|NFATC3_uc010vkp.1_5'UTR|NFATC3_uc010vkq.1_5'UTR|NFATC3_uc002evl.2_Intron|NFATC3_uc002evk.2_Missense_Mutation_p.H443Y|NFATC3_uc002evm.1_Missense_Mutation_p.H443Y|NFATC3_uc002evn.1_Missense_Mutation_p.H443Y|NFATC3_uc010vkr.1_5'UTR|NFATC3_uc010vks.1_5'UTR|NFATC3_uc010vkt.1_5'UTR|NFATC3_uc010vku.1_5'UTR|NFATC3_uc010vkv.1_5'UTR|NFATC3_uc010vkw.1_5'UTR|NFATC3_uc010vkx.1_5'UTR|NFATC3_uc010vky.1_5'UTR|NFATC3_uc010vkz.1_5'UTR|NFATC3_uc010vla.1_5'UTR|NFATC3_uc010vlb.1_5'UTR|NFATC3_uc010vlc.1_5'UTR	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	443	RHD.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TAAAACTCATCATCGAGCCCA	0.433													33	71					0	0	0	0	T	68160439	T	T	68160439	3	4	8	1	0	0	0	0	1	0	0	0	10418	826	29	2	1337	2	NFATC3	16	68160439	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	690566	68160439	22194314	481	2370											
ZFP1	162239	broad.mit.edu	37	chr16	75203755	75203755	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccggaatgtggaaaagctttCacccaccagtcaaacctcat	13	8	7	13	1	3	0	3	0	0	0	3	2	3	2	4	2	2	1	4	2	4	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:75203755C>T	uc002fdo.2	+	4	911	c.747C>T	c.(745-747)TTC>TTT	p.F249F	ZFP1_uc002fdp.2_Silent_p.F194F|ZFP1_uc010cgt.2_Silent_p.F216F|ZFP1_uc010cgs.2_Silent_p.F194F|ZFP1_uc002fdq.2_Silent_p.F249F	NM_153688	NP_710155	Q6P2D0	ZFP1_HUMAN	zinc finger protein 1 homolog	249	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GAAAAGCTTTCACCCACCAGT	0.443													28	59					0	0	0	0	T	75203755	T	T	75203755	2	4	8	1	0	0	0	0	0	0	0	1	17703	825	29	2		2	ZFP1	16	75203755	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7043316	75203755	15150998	482	2371											
PKD1L2	114780	broad.mit.edu	37	chr16	81145966	81145966	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggctgctgctgtctcactGaagctgatgcctctgtggga	5	12	13	11	1	2	2	1	2	2	0	4	3	2	3	1	2	4	4	1	2	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:81145966G>A	uc002fgh.1	-	42	6786	c.6786C>T	c.(6784-6786)TTC>TTT	p.F2262F	PKD1L2_uc002fgf.1_Silent_p.F62F|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2262	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTGTCTCACTGAAGCTGATGC	0.532													19	38					0	0	0	0	A	81145966	A	A	81145966	2	1	8	1	0	0	0	0	0	0	0	1	12020	1281	45	2		2	PKD1L2	16	81145966	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	5942211	81145966	9208787	483	2372											
TRAPPC2L	51693	broad.mit.edu	37	chr16	88925146	88925146	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatggggaaggccctggtCgaccagagggagctgtacct	9	6	16	10	1	0	1	0	0	0	1	1	4	0	3	3	5	2	3	3	5	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:88925146C>A	uc002fmc.2	+	2	206	c.153C>A	c.(151-153)GTC>GTA	p.V51V	GALNS_uc002fly.3_5'Flank|GALNS_uc010cid.2_5'Flank|GALNS_uc002flz.3_5'Flank|GALNS_uc002fma.2_5'Flank|TRAPPC2L_uc010cie.2_RNA|TRAPPC2L_uc002fmd.3_Silent_p.V51V|TRAPPC2L_uc002fme.3_Silent_p.V51V|TRAPPC2L_uc002fmf.2_5'Flank|uc002fmg.2_5'Flank	NM_016209	NP_057293	Q9UL33	TPC2L_HUMAN	trafficking protein particle complex 2-like	51					ER to Golgi vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm					0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		AGGCCCTGGTCGACCAGAGGG	0.577													15	51					0.00316338	0.00320851	1	0	A	88925146	A	A	88925146	2	1	8	1	0	0	0	0	0	0	0	1	16526	871	31	3		3	TRAPPC2L	16	88925146	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7779180	88925146	1429607	484	2373											
ABR	29	broad.mit.edu	37	chr17	960284	960284	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtgtacagtcctaagcttGaaacaggatcctgtgagcac	11	11	10	9	0	0	2	0	2	0	0	2	3	2	3	2	1	4	3	2	1	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:960284G>C	uc002fsd.2	-	13	1550	c.1440C>G	c.(1438-1440)TTC>TTG	p.F480L	ABR_uc002fse.2_Missense_Mutation_p.F434L|ABR_uc010vqg.1_Missense_Mutation_p.F262L|ABR_uc002fsg.2_Missense_Mutation_p.F443L|ABR_uc002fsh.1_Intron	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	480	C2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		TCCTAAGCTTGAAACAGGATC	0.582													82	118					0	0	0	0	C	960284	C	C	960284	3	2	8	1	0	0	0	0	1	0	0	0	99	1281	45	2	1183	2	ABR	17	960284	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08		960284	80234926	485	2374											
TMEM95	339168	broad.mit.edu	37	chr17	7259355	7259355	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttcatttcagctctctgTccccccgcctgccgtgagta	4	14	7	16	2	4	1	2	1	2	0	6	1	5	1	5	0	2	2	5	0	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:7259355T>C	uc002ggh.1	+	4	342	c.315T>C	c.(313-315)TGT>TGC	p.C105C	TMEM95_uc002ggf.1_Silent_p.C105C|TMEM95_uc002ggg.1_Silent_p.C105C	NM_198154	NP_937797	Q3KNT9	TMM95_HUMAN	transmembrane protein 95	105	Extracellular (Potential).					integral to membrane					0		Prostate(122;0.173)				CAGCTCTCTGTCCCCCCGCCT	0.592											OREG0024137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	104					0	0	0	0	C	7259355	C	C	7259355	2	2	8	1	0	0	0	0	0	0	0	1	16289	1673	58	5		5	TMEM95	17	7259355	Silent	SNP	T	TCGA-BA-5152-01A-02D-1870-08	6299071	7259355	73935855	486	2375											
TP53	7157	broad.mit.edu	37	chr17	7577548	7577548	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgggcctccggttcatgcCgcccatgcaggaactgttac	7	9	12	13	2	1	0	1	0	0	0	2	2	2	1	4	3	4	3	4	3	2	2	rs28934575		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			43	59					0	0	0	0	T	7577548	T	T	7577548	3	4	8	1	0	0	0	0	1	0	0	0	16448	652	23	1	557	1	TP53	17	7577548	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	318193	7577548	73617662	487	2376											
MYH13	8735	broad.mit.edu	37	chr17	10206785	10206785	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcagctcccctcttctgttCcacatcaagctcattttcca	7	15	3	16	0	5	0	3	0	2	0	8	0	8	0	4	0	2	3	4	0	1	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:10206785C>T	uc002gmk.1	-	38	5587	c.5497G>A	c.(5497-5499)GAA>AAA	p.E1833K		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1833	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CTCTTCTGTTCCACATCAAGC	0.517													74	106					0	0	0	0	T	10206785	T	T	10206785	3	4	8	1	0	0	0	0	1	0	0	0	10085	864	30	2	335	2	MYH13	17	10206785	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2629237	10206785	70988425	488	2377											
LRRC48	83450	broad.mit.edu	37	chr17	17898417	17898417	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcctggtgtcggtgagctCcttgagacatatccttctga	6	13	11	11	1	1	3	0	3	1	1	4	4	3	3	3	2	2	1	3	2	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:17898417C>A	uc010vxd.1	+	9	1195	c.816C>A	c.(814-816)CTC>CTA	p.L272L	LRRC48_uc002gsa.2_Silent_p.L272L|LRRC48_uc010vxc.1_Silent_p.L272L|LRRC48_uc002gsb.2_Silent_p.L272L|LRRC48_uc010vxe.1_5'Flank	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	272						cytoplasm				pancreas(1)	1	all_neural(463;0.228)					TCGGTGAGCTCCTTGAGACAT	0.338													25	21					3.7963e-18	4.05891e-18	1	0	A	17898417	A	A	17898417	2	1	8	1	0	0	0	0	0	0	0	1	9055	842	30	2		2	LRRC48	17	17898417	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7691632	17898417	63296793	489	2378											
MAP2K3	5606	broad.mit.edu	37	chr17	21208407	21208407	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccagaagggctacaatgtCaagtccgacgtctggagcct	12	7	11	11	2	2	1	1	0	1	1	3	3	3	2	3	2	3	1	3	2	5	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:21208407C>T	uc002gys.2	+	9	1006	c.741C>T	c.(739-741)GTC>GTT	p.V247V	MAP2K3_uc002gyt.2_Silent_p.V218V|MAP2K3_uc002gyu.2_Silent_p.V218V	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	247	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GCTACAATGTCAAGTCCGACG	0.592													25	125					0	0	0	0	T	21208407	T	T	21208407	2	4	8	1	0	0	0	0	0	0	0	1	9291	813	29	2		2	MAP2K3	17	21208407	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3309990	21208407	59986803	490	2379											
ATAD5	79915	broad.mit.edu	37	chr17	29220740	29220740	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaacaatccagagacaaaGaaatctattccttgtcctcc	15	9	6	11	0	1	2	0	0	1	2	5	4	5	3	4	1	1	0	4	1	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:29220740G>A	uc002hfs.1	+	21	5215	c.4869G>A	c.(4867-4869)AAG>AAA	p.K1623K		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1623					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				CAGAGACAAAGAAATCTATTC	0.393													61	101					0	0	0	0	A	29220740	A	A	29220740	2	1	8	1	0	0	0	0	0	0	0	1	1078	933	33	2		2	ATAD5	17	29220740	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8012333	29220740	51974470	491	2380											
C17orf75	64149	broad.mit.edu	37	chr17	30661853	30661853	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttcaacaggagtgtaactCaaagcctatgagagaaaaat	18	8	8	7	0	2	2	2	1	0	1	2	4	2	3	1	1	3	1	1	1	6	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:30661853C>G	uc002hhg.2	-	7	706	c.675G>C	c.(673-675)TTG>TTC	p.L225F		NM_022344	NP_071739	Q9HAS0	NJMU_HUMAN	hypothetical protein LOC64149	225					spermatogenesis					ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			GAGTGTAACTCAAAGCCTATG	0.363													10	21					0	0	0	0	G	30661853	G	G	30661853	3	3	8	1	0	0	0	0	1	0	0	0	1888	825	29	2	531	2	C17orf75	17	30661853	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1441113	30661853	50533357	492	2381											
C17orf75	64149	broad.mit.edu	37	chr17	30662447	30662447	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agataggattttatgtgactCtccaggccccttgcctaaat	10	13	8	10	0	1	2	0	1	1	1	2	3	1	3	4	2	1	0	4	2	4	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:30662447C>G	uc002hhg.2	-	6	595	c.564G>C	c.(562-564)GAG>GAC	p.E188D		NM_022344	NP_071739	Q9HAS0	NJMU_HUMAN	hypothetical protein LOC64149	188					spermatogenesis					ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			TTATGTGACTCTCCAGGCCCC	0.398													27	150					0	0	0	0	G	30662447	G	G	30662447	3	3	8	1	0	0	0	0	1	0	0	0	1888	912	32	2	646	2	C17orf75	17	30662447	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	594	30662447	50532763	493	2382											
LIG3	3980	broad.mit.edu	37	chr17	33316674	33316674	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggacttccttcggaaaggctCagcaggaggtgtggcatgag	9	8	16	8	1	1	1	1	1	0	0	3	4	2	4	1	6	1	3	1	6	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:33316674C>T	uc002hik.1	+	4	989	c.881C>T	c.(880-882)TCA>TTA	p.S294L	LIG3_uc002hii.2_Missense_Mutation_p.S294L|LIG3_uc002hij.2_Missense_Mutation_p.S294L|LIG3_uc010cth.1_Missense_Mutation_p.S303L	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	294					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	CGGAAAGGCTCAGCAGGAGGT	0.423								Other_BER_factors					21	98					0	0	0	0	T	33316674	T	T	33316674	3	4	8	1	0	0	0	0	1	0	0	0	8823	838	29	2	891	2	LIG3	17	33316674	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2654227	33316674	47878536	494	2383											
PLXDC1	57125	broad.mit.edu	37	chr17	37264415	37264415	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggagttgtcggagtagcCagggttgaagttggccatca	8	11	16	6	1	1	1	1	1	0	0	2	3	1	3	2	4	1	4	2	4	2	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:37264415C>T	uc002hrg.2	-	5	765	c.553G>A	c.(553-555)GGC>AGC	p.G185S	uc002hrf.1_3'UTR|PLXDC1_uc002hrh.2_RNA|PLXDC1_uc002hri.2_RNA|PLXDC1_uc002hrj.1_RNA|PLXDC1_uc002hrk.1_RNA	NM_020405	NP_065138	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1 precursor	185	Extracellular (Potential).				angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				ovary(1)|kidney(1)|skin(1)	3						TCGGAGTAGCCAGGGTTGAAG	0.522													51	107					0	0	0	0	T	37264415	T	T	37264415	3	4	8	1	0	0	0	0	1	0	0	0	12172	594	21	4	989	4	PLXDC1	17	37264415	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3947741	37264415	43930795	495	2384											
MSL1	339287	broad.mit.edu	37	chr17	38285648	38285648	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgtttgtaaacgtgaattGaggagccaagaaaccccaga	15	8	10	8	1	0	4	0	2	0	2	0	5	0	5	3	1	3	2	3	1	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:38285648G>C	uc002hub.2	+	3	559	c.540G>C	c.(538-540)TTG>TTC	p.L180F	MSL1_uc002hua.3_Missense_Mutation_p.L118F|MSL1_uc002huc.2_Missense_Mutation_p.L118F|MSL1_uc002hud.2_5'Flank	NM_001012241	NP_001012241	Q68DK7	MSL1_HUMAN	hampin	381					histone H4-K16 acetylation	MSL complex					0						AACGTGAATTGAGGAGCCAAG	0.473													19	109					0	0	0	0	C	38285648	C	C	38285648	3	2	8	1	0	0	0	0	1	0	0	0	9930	1281	45	2	360	2	MSL1	17	38285648	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1021233	38285648	42909562	496	2385											
TOP2A	7153	broad.mit.edu	37	chr17	38567942	38567942	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagctaatttgctgaaagccTttttcactcatagttaaaca	14	14	5	8	0	2	1	2	1	0	0	2	1	2	1	1	0	4	3	1	0	6	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:38567942T>C	uc002huq.2	-	8	1044	c.918A>G	c.(916-918)AAA>AAG	p.K306K	TOP2A_uc002hur.1_5'Flank	NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	306					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	GCTGAAAGCCTTTTTCACTCA	0.318													3	93					0	0	0	0	C	38567942	C	C	38567942	2	2	8	1	0	0	0	0	0	0	0	1	16432	1606	56	5		5	TOP2A	17	38567942	Silent	SNP	T	TCGA-BA-5152-01A-02D-1870-08	282294	38567942	42627268	497	2386											
DHX8	1659	broad.mit.edu	37	chr17	41599574	41599574	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccatccttccagtgccctCttcaacagacagccagaatg	11	9	6	15	0	2	2	1	0	1	2	5	2	5	2	5	0	3	0	5	0	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:41599574C>T	uc002idu.1	+	22	3496	c.3423C>T	c.(3421-3423)CTC>CTT	p.L1141L	DHX8_uc010wig.1_Silent_p.L1141L	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	1141						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		CCAGTGCCCTCTTCAACAGAC	0.512													14	57					0	0	0	0	T	41599574	T	T	41599574	2	4	8	1	0	0	0	0	0	0	0	1	4537	900	32	2		2	DHX8	17	41599574	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3031632	41599574	39595636	498	2387											
PLEKHM1	9842	broad.mit.edu	37	chr17	43517535	43517535	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catgacactcttacctgttgGaggtcagcaacactgaacct	11	10	8	12	0	2	2	1	2	1	0	2	3	2	3	2	2	4	2	2	2	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:43517535G>A	uc002ija.2	-	10	3065	c.2895C>T	c.(2893-2895)CTC>CTT	p.L965L	PLEKHM1_uc010wjm.1_Silent_p.L937L|PLEKHM1_uc002ijb.2_Silent_p.L440L|PLEKHM1_uc010wjn.1_Silent_p.L914L	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	965					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					TTACCTGTTGGAGGTCAGCAA	0.473													16	105					0	0	0	0	A	43517535	A	A	43517535	2	1	8	1	0	0	0	0	0	0	0	1	12135	1161	41	2		2	PLEKHM1	17	43517535	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1917961	43517535	37677675	499	2388											
LPO	4025	broad.mit.edu	37	chr17	56342211	56342211	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcttcaccttcgccttccgCtttggccacttggaggtccc	3	13	9	16	2	2	0	1	0	1	0	5	1	4	1	5	3	0	1	5	3	0	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:56342211C>G	uc002ivt.2	+	10	1711	c.1395C>G	c.(1393-1395)CGC>CGG	p.R465R	LPO_uc010wns.1_Silent_p.R406R|LPO_uc010dcp.2_Silent_p.R382R|LPO_uc010dcq.2_Silent_p.R136R|LPO_uc010dcr.2_Silent_p.R28R	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	465					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						TCGCCTTCCGCTTTGGCCACT	0.517													15	103					0	0	0	0	G	56342211	G	G	56342211	2	3	8	1	0	0	0	0	0	0	0	1	8972	784	28	4		4	LPO	17	56342211	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	12824676	56342211	24852999	500	2389											
RNF43	54894	broad.mit.edu	37	chr17	56440747	56440747	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaacaccactggccaggtCagccccagcggctgctgcag	9	5	11	16	1	2	0	2	0	0	0	2	0	2	0	4	3	5	3	4	3	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:56440747C>T	uc002iwf.2	-	4	2427	c.471G>A	c.(469-471)CTG>CTA	p.L157L	RNF43_uc010wnv.1_Silent_p.L116L|RNF43_uc002iwh.3_Silent_p.L157L|RNF43_uc002iwg.3_Silent_p.L157L|RNF43_uc010dcw.2_Silent_p.L30L	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	157	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGGCCAGGTCAGCCCCAGCG	0.567													17	165					0	0	0	0	T	56440747	T	T	56440747	2	4	8	1	0	0	0	0	0	0	0	1	13560	813	29	2		2	RNF43	17	56440747	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	98536	56440747	24754463	501	2390											
KPNA2	3838	broad.mit.edu	37	chr17	66033573	66033573	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtaagctcatttcctgatGatgctacttctccgctgcag	8	14	8	11	1	2	2	1	2	1	0	4	2	3	2	2	0	4	5	2	0	2	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:66033573G>A	uc002jgk.2	+	3	307	c.175G>A	c.(175-177)GAT>AAT	p.D59N	KPNA2_uc002jgl.2_Missense_Mutation_p.D59N	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	59	IBB.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATTTCCTGATGATGCTACTTC	0.423													65	78					0	0	0	0	A	66033573	A	A	66033573	3	1	8	1	0	0	0	0	1	0	0	0	8469	1290	45	2	181	2	KPNA2	17	66033573	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	9592826	66033573	15161637	502	2391											
ABCA10	10349	broad.mit.edu	37	chr17	67150091	67150091	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctgagggcagtaccccaaGaacttgaggctgttgtcatg	9	10	12	10	0	1	3	1	2	0	1	2	3	2	3	3	2	2	4	3	2	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:67150091G>A	uc010dfa.1	-	33	4725	c.3846C>T	c.(3844-3846)TTC>TTT	p.F1282F	ABCA10_uc010wqs.1_Silent_p.F274F|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1282	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					AGTACCCCAAGAACTTGAGGC	0.478													27	124					0	0	0	0	A	67150091	A	A	67150091	2	1	8	1	0	0	0	0	0	0	0	1	29	933	33	2		2	ABCA10	17	67150091	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1116518	67150091	14045119	503	2392											
FAM104A	84923	broad.mit.edu	37	chr17	71228289	71228289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgcggcgccgctccgcgaaGagagggaacagagggggttg	9	3	19	10	6	0	2	0	0	0	2	1	5	1	3	2	4	1	2	2	4	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:71228289G>A	uc002jji.3	-	1	245	c.157C>T	c.(157-159)CTT>TTT	p.L53F	FAM104A_uc002jjj.3_Missense_Mutation_p.L53F|C17orf80_uc010wqu.1_5'Flank|C17orf80_uc010dfj.2_5'Flank|C17orf80_uc002jjk.1_5'Flank|C17orf80_uc002jjm.3_5'Flank|C17orf80_uc002jjl.3_5'Flank	NM_032837	NP_116226	Q969W3	F104A_HUMAN	hypothetical protein LOC84923 isoform 2	53											0			LUSC - Lung squamous cell carcinoma(166;0.197)			GCTCCGCGAAGAGAGGGAACA	0.701													4	32					0	0	0	0	A	71228289	A	A	71228289	3	1	8	1	0	0	0	0	1	0	0	0	5413	942	33	2	482	2	FAM104A	17	71228289	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4078198	71228289	9966921	504	2393											
CD300A	11314	broad.mit.edu	37	chr17	72469964	72469964	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggtggatacaccatggctCcgagactttcatgatcccgt	8	10	12	11	2	1	2	1	1	0	1	3	4	3	3	3	4	1	1	3	4	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:72469964C>T	uc002jkv.2	+	2	651	c.330C>T	c.(328-330)CTC>CTT	p.L110L	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	110	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						CACCATGGCTCCGAGACTTTC	0.562													12	109					0	0	0	0	T	72469964	T	T	72469964	2	4	8	1	0	0	0	0	0	0	0	1	3011	842	30	2		2	CD300A	17	72469964	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1241675	72469964	8725246	505	2394											
GALR2	8811	broad.mit.edu	37	chr17	74071153	74071153	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcagcactaccaacctgttCatccttaacctgggcgtggc	8	10	9	14	1	2	0	2	0	0	0	3	0	3	0	4	2	4	2	4	2	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:74071153C>T	uc002jqm.1	+	1	270	c.189C>T	c.(187-189)TTC>TTT	p.F63F	SRP68_uc010wsu.1_5'Flank|SRP68_uc002jqk.1_5'Flank|SRP68_uc002jql.1_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	63	Helical; Name=2; (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						CCAACCTGTTCATCCTTAACC	0.652													11	70					0	0	0	0	T	74071153	T	T	74071153	2	4	8	1	0	0	0	0	0	0	0	1	6263	825	29	2		2	GALR2	17	74071153	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1601189	74071153	7124057	506	2395											
GALR2	8811	broad.mit.edu	37	chr17	74071276	74071276	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaaggcggtgcacttcctCatcttcctcaccatgcacgc	7	10	8	16	2	3	0	2	0	1	0	5	0	5	0	3	2	3	3	3	2	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:74071276C>T	uc002jqm.1	+	1	393	c.312C>T	c.(310-312)CTC>CTT	p.L104L	SRP68_uc010wsu.1_5'Flank|SRP68_uc002jqk.1_5'Flank|SRP68_uc002jql.1_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	104	Helical; Name=3; (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						TGCACTTCCTCATCTTCCTCA	0.647													14	70					0	0	0	0	T	74071276	T	T	74071276	2	4	8	1	0	0	0	0	0	0	0	1	6263	813	29	2		2	GALR2	17	74071276	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	123	74071276	7123934	507	2396											
ZACN	353174	broad.mit.edu	37	chr17	74077658	74077658	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacacggcgctcaagtccatCatcgctctcttggtgcctgc	7	10	9	15	3	3	0	2	0	1	0	6	0	4	0	2	2	3	2	2	2	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:74077658C>G	uc002jqn.2	+	7	785	c.702C>G	c.(700-702)ATC>ATG	p.I234M	ZACN_uc002jqo.2_RNA|ZACN_uc010dgu.2_Intron|EXOC7_uc002jqp.1_3'UTR|EXOC7_uc010dgv.1_3'UTR|EXOC7_uc002jqs.2_3'UTR|EXOC7_uc002jqq.2_3'UTR|EXOC7_uc010wsw.1_3'UTR|EXOC7_uc010wsx.1_3'UTR|EXOC7_uc002jqr.2_3'UTR|EXOC7_uc010wsv.1_3'UTR	NM_180990	NP_851321	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	234	Leu-rich.|Helical; Name=1; (Potential).				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity				0						TCAAGTCCATCATCGCTCTCT	0.642													4	175					0	0	0	0	G	74077658	G	G	74077658	3	3	8	1	0	0	0	0	1	0	0	0	17578	816	29	2	728	2	ZACN	17	74077658	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	6382	74077658	7117552	508	2397											
RHBDF2	79651	broad.mit.edu	37	chr17	74475233	74475233	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcctggctggggagctcCaggtcacgctggcacgaggc	5	6	16	14	2	1	0	1	0	0	0	3	2	3	1	3	6	1	4	3	6	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:74475233C>T	uc002jrq.1	-	5	779	c.486G>A	c.(484-486)CTG>CTA	p.L162L	RHBDF2_uc002jrp.1_Silent_p.L133L|RHBDF2_uc002jrr.1_Silent_p.L14L|RHBDF2_uc010wtf.1_Silent_p.L133L|RHBDF2_uc002jrs.1_Silent_p.L133L	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	162	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						TGGGGAGCTCCAGGTCACGCT	0.692													11	77					0	0	0	0	T	74475233	T	T	74475233	2	4	8	1	0	0	0	0	0	0	0	1	13385	581	21	4		4	RHBDF2	17	74475233	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	397575	74475233	6719977	509	2398											
SEPT9	10801	broad.mit.edu	37	chr17	75398526	75398526	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggaggacggagatcaccatCgtcaaaccccaggagtcagc	12	4	12	13	3	3	1	3	0	0	1	4	5	3	4	3	4	2	0	3	4	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:75398526C>T	uc002jts.3	+	3	588	c.462C>T	c.(460-462)ATC>ATT	p.I154I	SEPT9_uc010wtk.1_Silent_p.I135I|SEPT9_uc002jtt.3_5'UTR|SEPT9_uc002jtu.3_Silent_p.I136I|SEPT9_uc002jtv.2_Silent_p.I147I|SEPT9_uc002jtw.2_5'UTR|SEPT9_uc002jtx.1_5'UTR|SEPT9_uc010wtl.1_5'Flank	NM_001113491	NP_001106963	Q9UHD8	SEPT9_HUMAN	septin 9 isoform a	154					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding|protein binding			breast(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(99;0.153)			AGATCACCATCGTCAAACCCC	0.706													8	13					0	0	0	0	T	75398526	T	T	75398526	2	4	8	1	0	0	0	0	0	0	0	1	14136	874	31	1		1	SEPT9	17	75398526	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	923293	75398526	5796684	510	2399											
NPTX1	4884	broad.mit.edu	37	chr17	78449452	78449452	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacctgcctctccagctcatCgatcttgctctgcagcagat	7	11	7	16	1	4	1	1	0	3	1	6	2	4	1	3	0	5	4	3	0	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:78449452C>G	uc002jyp.1	-	2	669	c.511G>C	c.(511-513)GAT>CAT	p.D171H		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	neuronal pentraxin I precursor	171					central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			TCCAGCTCATCGATCTTGCTC	0.637													17	48					0	0	0	0	G	78449452	G	G	78449452	3	3	8	1	0	0	0	0	1	0	0	0	10656	884	31	3	803	3	NPTX1	17	78449452	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3050926	78449452	2745758	511	2400											
AATK	9625	broad.mit.edu	37	chr17	79094803	79094803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgagggaggtggagagcCgtgtctcgggcccggggccc	5	5	19	12	3	1	2	0	1	1	1	2	4	1	3	3	6	1	0	3	6	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:79094803C>T	uc010dia.2	-	11	3013	c.2933G>A	c.(2932-2934)CGG>CAG	p.R978Q	AATK_uc010dhz.2_Intron	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	978						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GGTGGAGAGCCGTGTCTCGGG	0.652													4	24					0	0	0	0	T	79094803	T	T	79094803	3	4	8	1	0	0	0	0	1	0	0	0	26	652	23	1	1207	1	AATK	17	79094803	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	645351	79094803	2100407	512	2401											
FASN	2194	broad.mit.edu	37	chr17	80054216	80054216	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgccttccagcgacggtcatCgtccgtgaccatgtccacac	7	8	9	17	5	1	1	1	1	0	0	5	2	4	1	5	1	1	0	5	1	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:80054216C>T	uc002kdu.2	-	2	223	c.106G>A	c.(106-108)GAT>AAT	p.D36N		NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	36	Beta-ketoacyl synthase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CGACGGTCATCGTCCGTGACC	0.632													12	92					0	0	0	0	T	80054216	T	T	80054216	3	4	8	1	0	0	0	0	1	0	0	0	5715	884	31	1	7597	1	FASN	17	80054216	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	959413	80054216	1140994	513	2402											
CCDC57	284001	broad.mit.edu	37	chr17	80141798	80141798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agattttacagttgatgcatCttcacgaagtctaaacatag	14	13	7	7	1	3	2	1	1	2	1	3	3	3	2	0	0	3	2	0	0	5	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:80141798C>T	uc002kdz.1	-	9	1418	c.1063G>A	c.(1063-1065)GAT>AAT	p.D355N	CCDC57_uc002kdx.1_Missense_Mutation_p.D355N|CCDC57_uc010dik.1_5'UTR	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	355	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			GTTGATGCATCTTCACGAAGT	0.453													24	32					0	0	0	0	T	80141798	T	T	80141798	3	4	8	1	0	0	0	0	1	0	0	0	2840	913	32	2	1724	2	CCDC57	17	80141798	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	87582	80141798	1053412	514	2403											
LRRC30	339291	broad.mit.edu	37	chr18	7232012	7232012	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gggggcctggagatgctcttCggctacctgaaggacaaaaa	11	7	14	9	1	1	2	0	1	1	1	2	4	1	3	2	5	2	2	2	5	4	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:7232012C>G	uc010wzk.1	+	1	876	c.876C>G	c.(874-876)TTC>TTG	p.F292L		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	292										ovary(1)|liver(1)	2						AGATGCTCTTCGGCTACCTGA	0.587													66	137					0	0	0	0	G	7232012	G	G	7232012	3	3	8	1	0	0	0	0	1	0	0	0	9035	883	31	3	878	3	LRRC30	18	7232012	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		7232012	70845236	515	2404											
ROCK1	6093	broad.mit.edu	37	chr18	18566941	18566941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcctttctttatttccagtCaaatgttctagtttctgctg	7	20	5	9	0	4	0	1	0	3	0	6	0	6	0	2	0	1	3	2	0	3	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:18566941C>G	uc002kte.2	-	19	3215	c.2274G>C	c.(2272-2274)TTG>TTC	p.L758F		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	758	Glu-rich.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TATTTCCAGTCAAATGTTCTA	0.368													8	111					0	0	0	0	G	18566941	G	G	18566941	3	3	8	1	0	0	0	0	1	0	0	0	13582	825	29	2	1850	2	ROCK1	18	18566941	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	11334929	18566941	59510307	516	2405											
ROCK1	6093	broad.mit.edu	37	chr18	18586476	18586476	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggactctaactgactaattGacttgctcatctctgtgtga	9	14	9	9	0	3	3	1	3	2	0	4	4	3	4	0	1	2	1	0	1	2	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:18586476G>A	uc002kte.2	-	16	2662	c.1721C>T	c.(1720-1722)TCA>TTA	p.S574L		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	574	Interaction with FHOD1.|Potential.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					CTGACTAATTGACTTGCTCAT	0.383													44	121					0	0	0	0	A	18586476	A	A	18586476	3	1	8	1	0	0	0	0	1	0	0	0	13582	1294	45	2	2415	2	ROCK1	18	18586476	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	19535	18586476	59490772	517	2406											
ZNF521	25925	broad.mit.edu	37	chr18	22805754	22805754	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgtccagcaggtgtttctGaaggtcatccactgatgtga	9	12	11	9	0	2	3	1	3	1	0	4	3	4	3	2	2	1	2	2	2	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:22805754G>A	uc002kvk.2	-	4	2375	c.2128C>T	c.(2128-2130)CAG>TAG	p.Q710*	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Nonsense_Mutation_p.Q710*|ZNF521_uc002kvl.2_Nonsense_Mutation_p.Q490*	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	710	C2H2-type 16.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGGTGTTTCTGAAGGTCATCC	0.443			T	PAX5	ALL								24	101					0	0	0	0	A	22805754	A	A	22805754	4	1	8	1	0	0	0	0	0	1	0	0	18032	1299	45	2	1827	2	ZNF521	18	22805754	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4219278	22805754	55271494	518	2407											
ZNF397OS	100101467	broad.mit.edu	37	chr18	32843968	32843968	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcatagtcacagcttcctCtccattctctggccgatgct	7	12	7	15	1	3	0	1	0	2	0	6	1	4	0	3	1	3	3	3	1	1	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:32843968C>G	uc002kym.2	-	2	577	c.349G>C	c.(349-351)GAG>CAG	p.E117Q	ZNF397_uc010dmr.2_Intron|ZNF397OS_uc010xce.1_Missense_Mutation_p.E117Q|ZNF397OS_uc002kyn.1_Missense_Mutation_p.E117Q	NM_001112734	NP_001106205	Q86W11	ZSC30_HUMAN	zinc finger protein 397 opposite strand	117	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACAGCTTCCTCTCCATTCTCT	0.498													11	70					0	0	0	0	G	32843968	G	G	32843968	3	3	8	1	0	0	0	0	1	0	0	0	17951	922	32	2	1147	2	ZNF397OS	18	32843968	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	10038214	32843968	45233280	519	2408											
KATNAL2	83473	broad.mit.edu	37	chr18	44595607	44595607	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttagtatccacagctatttaCaggaattctttctccctgga	10	15	6	10	0	2	0	0	0	2	0	4	2	3	2	2	2	2	2	2	2	5	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:44595607C>T	uc002lco.2	+	9	820	c.626C>T	c.(625-627)ACA>ATA	p.T209I	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lcp.3_Missense_Mutation_p.T136I	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	281						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						CAGCTATTTACAGGAATTCTT	0.463													25	94					0	0	0	0	T	44595607	T	T	44595607	3	4	8	1	0	0	0	0	1	0	0	0	8025	478	17	4	656	4	KATNAL2	18	44595607	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	11751639	44595607	33481641	520	2409											
CTDP1	9150	broad.mit.edu	37	chr18	77474881	77474881	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagtcctcctcctccgcctCtgatggcgaaagcgagggga	8	7	13	13	3	1	1	0	1	1	0	5	5	5	2	5	3	1	0	5	3	2	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:77474881C>G	uc002lnh.1	+	8	1568	c.1421C>G	c.(1420-1422)TCT>TGT	p.S474C	CTDP1_uc002lni.1_Missense_Mutation_p.S474C|CTDP1_uc010drd.1_Missense_Mutation_p.S474C	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	474	Ser-rich.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		TCCTCCGCCTCTGATGGCGAA	0.677													2	4					0	0	0	0	G	77474881	G	G	77474881	3	3	8	1	0	0	0	0	1	0	0	0	4019	913	32	2	1451	2	CTDP1	18	77474881	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	32879274	77474881	602367	521	2410											
SHC2	25759	broad.mit.edu	37	chr19	422154	422154	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcacagcttaccacgccctCggggtccacgagcagcaggt	8	6	12	15	3	0	0	0	0	0	0	2	1	1	0	3	3	5	4	3	3	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:422154C>T	uc002loq.3	-	11	1612	c.1612G>A	c.(1612-1614)GAG>AAG	p.E538K	SHC2_uc002lop.3_Missense_Mutation_p.E279K	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	538	SH2.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCACGCCCTCGGGGTCCACG	0.687													5	10					0	0	0	0	T	422154	T	T	422154	3	4	8	1	0	0	0	0	1	0	0	0	14336	893	31	1	144	1	SHC2	19	422154	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		422154	58706829	522	2411											
POLRMT	5442	broad.mit.edu	37	chr19	621366	621366	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgagaggcggtacagcgcctCcgcccgcaggctgtgcatct	6	6	14	15	5	1	1	0	0	1	1	2	2	2	1	3	3	3	4	3	3	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:621366C>A	uc002lpf.1	-	10	2388	c.2332G>T	c.(2332-2334)GAG>TAG	p.E778*		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	778					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TACAGCGCCTCCGCCCGCAGG	0.746													4	10					0.00909568	0.00918612	1	0	A	621366	A	A	621366	4	1	8	1	0	0	0	0	0	1	0	0	12293	864	30	2	1408	2	POLRMT	19	621366	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	199212	621366	58507617	523	2412											
MEX3D	399664	broad.mit.edu	37	chr19	1556393	1556393	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtcgtccctggttgggggtCttggcccagaggctggcggc	2	9	18	12	3	1	1	0	0	1	1	3	1	2	1	2	7	0	2	2	7	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:1556393C>G	uc010dsn.2	-	2	1125	c.1125G>C	c.(1123-1125)AAG>AAC	p.K375N		NM_203304	NP_976049	Q86XN8	MEX3D_HUMAN	ring finger and KH domain containing 1	375					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTTGGGGGTCTTGGCCCAGA	0.776													3	9					0	0	0	0	G	1556393	G	G	1556393	3	3	8	1	0	0	0	0	1	0	0	0	9565	912	32	2	897	2	MEX3D	19	1556393	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	935027	1556393	57572590	524	2413											
TCF3	6929	broad.mit.edu	37	chr19	1621849	1621849	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccatacccaggaggctgtCggccccgctgacaggcggcg	6	4	16	15	4	0	1	0	1	0	0	1	2	0	2	4	6	1	2	4	6	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:1621849C>T	uc002ltr.2	-	11	1010	c.943G>A	c.(943-945)GAC>AAC	p.D315N	TCF3_uc002lto.2_Missense_Mutation_p.D77N|TCF3_uc002ltt.3_Missense_Mutation_p.D315N|TCF3_uc002ltq.2_Missense_Mutation_p.D264N|TCF3_uc002lts.1_Missense_Mutation_p.D231N|TCF3_uc010dso.1_5'Flank	NM_003200	NP_003191	P15923	TFE2_HUMAN	transcription factor 3 isoform E12	315					B cell lineage commitment|B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			lung(2)|breast(2)|ovary(1)|large_intestine(1)|skin(1)	7		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGAGGCTGTCGGCCCCGCTG	0.711			T	PBX1|HLF|TFPT	pre B-ALL								3	14					0	0	0	0	T	1621849	T	T	1621849	3	4	8	1	0	0	0	0	1	0	0	0	15760	884	31	1	1288	1	TCF3	19	1621849	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	65456	1621849	57507134	525	2414											
REXO1	57455	broad.mit.edu	37	chr19	1818554	1818554	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagcggcctgaagaggacacGaggtactcggtgccacagcg	10	4	15	12	4	0	2	0	1	0	1	1	4	0	3	2	4	4	1	2	4	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:1818554G>A	uc002lua.3	-	10	3038	c.2943C>T	c.(2941-2943)CTC>CTT	p.L981L	REXO1_uc010dsq.2_Silent_p.L290L|REXO1_uc010xgs.1_5'UTR|MIR1909_hsa-mir-1909|MI0008330_5'Flank|REXO1_uc010dsp.1_RNA	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	981						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGAGGACACGAGGTACTCGG	0.672													3	18					0	0	0	0	A	1818554	A	A	1818554	2	1	8	1	0	0	0	0	0	0	0	1	13306	1045	37	1		1	REXO1	19	1818554	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	196705	1818554	57310429	526	2415											
DIRAS1	148252	broad.mit.edu	37	chr19	2717417	2717417	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcgcctcgcgcgtgtccaCctcccgctgcgtctcatcgc	2	9	10	20	7	1	0	1	0	1	0	6	0	3	0	4	0	2	1	4	0	0	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:2717417C>T	uc002lwf.3	-	2	546	c.388G>A	c.(388-390)GTG>ATG	p.V130M		NM_145173	NP_660156	O95057	DIRA1_HUMAN	DIRAS family, GTP-binding RAS-like 1	130					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCGTGTCCACCTCCCGCTGC	0.617													15	32					0	0	0	0	T	2717417	T	T	2717417	3	4	8	1	0	0	0	0	1	0	0	0	4552	507	18	4	212	4	DIRAS1	19	2717417	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	898863	2717417	56411566	527	2416											
MAP2K2	5605	broad.mit.edu	37	chr19	4099284	4099284	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgaccacgggccggccaaaGatggcctccagctctttggc	7	7	12	15	3	1	1	0	0	1	1	3	2	2	1	5	4	1	1	5	4	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:4099284G>C	uc002lzk.2	-	7	1088	c.834C>G	c.(832-834)ATC>ATG	p.I278M	MAP2K2_uc002lzj.2_Missense_Mutation_p.I88M	NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	278	Protein kinase.|Pro-rich.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGGCCAAAGATGGCCTCCA	0.697									Cardiofaciocutaneous_syndrome				3	13					0	0	0	0	C	4099284	C	C	4099284	3	2	8	1	0	0	0	0	1	0	0	0	9290	932	33	2	388	2	MAP2K2	19	4099284	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1381867	4099284	55029699	528	2417											
SAFB	6294	broad.mit.edu	37	chr19	5664440	5664440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaggtcaatgatgggagaacGagaaggacaggtaagtctga	16	6	15	4	1	2	4	1	2	1	2	2	7	2	5	0	4	1	1	0	4	5	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:5664440G>A	uc002mcf.2	+	17	2377	c.2324G>A	c.(2323-2325)CGA>CAA	p.R775Q	SAFB_uc002mcg.2_Missense_Mutation_p.R775Q|SAFB_uc002mce.3_Missense_Mutation_p.R774Q|SAFB_uc010xir.1_Missense_Mutation_p.R774Q|SAFB_uc010xis.1_Missense_Mutation_p.R706Q|SAFB_uc010xit.1_Missense_Mutation_p.R617Q|SAFB_uc010xiu.1_Missense_Mutation_p.R574Q	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	775	Interaction with SAFB2.|Interaction with POLR2A.|Arg-rich.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		ATGGGAGAACGAGAAGGACAG	0.458													5	36					0	0	0	0	A	5664440	A	A	5664440	3	1	8	1	0	0	0	0	1	0	0	0	13871	1058	37	1	2390	1	SAFB	19	5664440	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1565156	5664440	53464543	529	2418											
DENND1C	79958	broad.mit.edu	37	chr19	6471307	6471307	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggcccagagctgataggatCgaagggcccctggggtaagg	9	5	17	10	2	0	2	0	1	0	1	1	4	0	3	3	6	1	2	3	6	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:6471307C>T	uc002mfe.2	-	17	1351	c.1259G>A	c.(1258-1260)CGA>CAA	p.R420Q	DENND1C_uc002mfb.2_5'UTR|DENND1C_uc002mfc.2_5'UTR|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Missense_Mutation_p.R376Q	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	420						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						CTGATAGGATCGAAGGGCCCC	0.463													7	11					0	0	0	0	T	6471307	T	T	6471307	3	4	8	1	0	0	0	0	1	0	0	0	4450	884	31	1	1174	1	DENND1C	19	6471307	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	806867	6471307	52657676	530	2419											
COL5A3	50509	broad.mit.edu	37	chr19	10085036	10085036	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactccgtcatctcctttctGcccaaagaggcctgggggtc	6	10	11	14	1	3	1	1	0	2	1	6	2	4	1	4	3	1	0	4	3	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:10085036G>T	uc002mmq.1	-	46	3477	c.3391C>A	c.(3391-3393)CAG>AAG	p.Q1131K		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1131	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TCTCCTTTCTGCCCAAAGAGG	0.542													14	38					1.49906e-05	1.54022e-05	1	0	T	10085036	T	T	10085036	3	4	8	1	0	0	0	0	1	0	0	0	3713	1328	46	4	1934	4	COL5A3	19	10085036	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3613729	10085036	49043947	531	2420											
EIF3G	8666	broad.mit.edu	37	chr19	10226446	10226446	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagctcctgcaggtcggtctCacgcgtgtcctctgacaagt	6	10	12	13	3	2	1	1	1	2	0	6	2	4	1	2	2	2	2	2	2	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:10226446C>G	uc002mnd.2	-	9	818	c.754G>C	c.(754-756)GAG>CAG	p.E252Q		NM_003755	NP_003746	O75821	EIF3G_HUMAN	eukaryotic translation initiation factor 3,	252	RRM.					cytosol|eukaryotic translation initiation factor 3 complex|nucleus|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0			OV - Ovarian serous cystadenocarcinoma(20;3.53e-09)|Epithelial(33;4.91e-06)|all cancers(31;1.1e-05)			AGGTCGGTCTCACGCGTGTCC	0.637													44	87					0	0	0	0	G	10226446	G	G	10226446	3	3	8	1	0	0	0	0	1	0	0	0	5041	835	29	2	220	2	EIF3G	19	10226446	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	141410	10226446	48902537	532	2421											
ICAM1	3383	broad.mit.edu	37	chr19	10395703	10395703	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtgaccgtgaatgtgctCtgtgagtgagccggcgggca	8	8	17	8	3	1	4	0	4	1	0	1	4	1	4	2	3	2	2	2	3	2	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:10395703C>T	uc002mnq.2	+	6	1744	c.1425C>T	c.(1423-1425)CTC>CTT	p.L475L	ICAM1_uc010xle.1_Silent_p.L253L|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	475	Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	TGAATGTGCTCTGTGAGTGAG	0.622													15	37					0	0	0	0	T	10395703	T	T	10395703	2	4	8	1	0	0	0	0	0	0	0	1	7518	927	32	2		2	ICAM1	19	10395703	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	169257	10395703	48733280	533	2422											
ICAM5	7087	broad.mit.edu	37	chr19	10402810	10402810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggacggactgtttccagcctCagaggccagggtctacctcg	7	8	13	13	2	2	1	1	0	1	1	4	3	3	3	4	4	2	1	4	4	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:10402810C>T	uc002mnu.3	+	4	838	c.773C>T	c.(772-774)TCA>TTA	p.S258L	ICAM5_uc002mnv.3_Missense_Mutation_p.S133L	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	258	Extracellular (Potential).|Ig-like C2-type 3.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			TTTCCAGCCTCAGAGGCCAGG	0.647													6	111					0	0	0	0	T	10402810	T	T	10402810	3	4	8	1	0	0	0	0	1	0	0	0	7522	838	29	2	787	2	ICAM5	19	10402810	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7107	10402810	48726173	534	2423											
DOCK6	57572	broad.mit.edu	37	chr19	11354276	11354276	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagctgcccagcgctgctCacgatgttggccaagtgcac	7	8	11	15	2	1	0	1	0	0	0	2	1	2	0	3	1	5	5	3	1	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:11354276C>T	uc002mqs.3	-	11	1256	c.1215G>A	c.(1213-1215)GTG>GTA	p.V405V		NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	405					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CAGCGCTGCTCACGATGTTGG	0.692											OREG0025252	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	17					0	0	0	0	T	11354276	T	T	11354276	2	4	8	1	0	0	0	0	0	0	0	1	4713	813	29	2		2	DOCK6	19	11354276	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	951466	11354276	47774707	535	2424											
ZNF625	90589	broad.mit.edu	37	chr19	12256165	12256165	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttggagctacagggtttttCtccagtgtgagtcctttcat	6	16	11	8	0	2	1	1	1	1	0	4	2	3	2	2	2	2	3	2	2	1	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:12256165C>T	uc002mth.2	-	4	1218	c.868G>A	c.(868-870)GAA>AAA	p.E290K	ZNF20_uc002mtg.1_Intron|ZNF625_uc010dyn.1_RNA|ZNF625_uc010dyo.1_Missense_Mutation_p.E324K	NM_145233	NP_660276	Q96I27	ZN625_HUMAN	zinc finger protein 625	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGGGTTTTTCTCCAGTGTGA	0.428													39	72					0	0	0	0	T	12256165	T	T	12256165	3	4	8	1	0	0	0	0	1	0	0	0	18116	922	32	2	56	2	ZNF625	19	12256165	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	901889	12256165	46872818	536	2425											
TRMT1	55621	broad.mit.edu	37	chr19	13226280	13226280	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttccagcacatgcaggccttCctgttggagtaagcagaaaa	12	9	10	10	0	0	1	0	0	0	1	2	2	2	2	3	2	3	5	3	2	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:13226280C>T	uc002mwj.2	-	4	704	c.454G>A	c.(454-456)GAA>AAA	p.E152K	NACC1_uc002mwm.2_5'Flank|TRMT1_uc002mwk.2_Missense_Mutation_p.E152K|TRMT1_uc002mwl.3_Missense_Mutation_p.E152K|TRMT1_uc010xmz.1_5'UTR	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	152							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		TGCAGGCCTTCCTGTTGGAGT	0.587													8	29					0	0	0	0	T	13226280	T	T	13226280	3	4	8	1	0	0	0	0	1	0	0	0	16628	869	30	2	1577	2	TRMT1	19	13226280	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	970115	13226280	45902703	537	2426											
OR10H4	126541	broad.mit.edu	37	chr19	16060070	16060070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcacccctcgcatgctggctGatctgctttccacccatcat	6	12	6	17	1	3	1	2	1	1	0	5	1	4	1	4	1	2	4	4	1	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:16060070G>A	uc010xov.1	+	1	253	c.253G>A	c.(253-255)GAT>AAT	p.D85N		NM_001004465	NP_001004465	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						CATGCTGGCTGATCTGCTTTC	0.507													6	349					0	0	0	0	A	16060070	A	A	16060070	3	1	8	1	0	0	0	0	1	0	0	0	10962	1290	45	2	255	2	OR10H4	19	16060070	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2833790	16060070	43068913	538	2427											
ZNF486	90649	broad.mit.edu	37	chr19	20307969	20307969	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caatgtttgacaactacccaGagcaaaatatttcaatgtgg	15	11	7	8	0	1	2	1	1	0	1	1	2	1	2	1	1	3	2	1	1	7	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:20307969G>C	uc002nou.2	+	4	507	c.450G>C	c.(448-450)CAG>CAC	p.Q150H		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAACTACCCAGAGCAAAATAT	0.303													33	95					0	0	0	0	C	20307969	C	C	20307969	3	2	8	1	0	0	0	0	1	0	0	0	18006	933	33	2	464	2	ZNF486	19	20307969	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	4247899	20307969	38821014	539	2428											
ZNF91	7644	broad.mit.edu	37	chr19	23544945	23544945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttatgtctagttagggttGaggaccatagaaatgctttg	10	15	11	5	0	2	2	0	1	2	1	2	3	2	3	1	2	1	3	1	2	5	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:23544945G>A	uc002nre.2	-	4	949	c.836C>T	c.(835-837)TCA>TTA	p.S279L	ZNF91_uc010xrj.1_Missense_Mutation_p.S247L	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	279	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGTTAGGGTTGAGGACCATAG	0.388													11	83					0	0	0	0	A	23544945	A	A	23544945	3	1	8	1	0	0	0	0	1	0	0	0	18267	1294	45	2	2743	2	ZNF91	19	23544945	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3236976	23544945	35584038	540	2429											
CATSPERG	57828	broad.mit.edu	37	chr19	38853162	38853162	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagggcactgagtacagcttCgccatcttcctgtcggcgca	8	9	11	13	3	1	1	0	1	1	0	4	1	2	1	2	2	2	4	2	2	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:38853162C>T	uc002oih.3	+	19	2391	c.2304C>T	c.(2302-2304)TTC>TTT	p.F768F	CATSPERG_uc002oig.3_Silent_p.F728F|CATSPERG_uc002oif.3_Silent_p.F408F|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	768	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane		p.S768F(1)		ovary(1)|skin(1)	2						AGTACAGCTTCGCCATCTTCC	0.612													9	54					0	0	0	0	T	38853162	T	T	38853162	2	4	8	1	0	0	0	0	0	0	0	1	2704	883	31	1		1	CATSPERG	19	38853162	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	15308217	38853162	20275821	541	2430											
FCGBP	8857	broad.mit.edu	37	chr19	40368869	40368869	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggcaaggctgtgagcacaCcgttcacctgggggaaggag	10	5	16	10	1	1	1	1	1	0	0	1	3	1	3	2	5	1	4	2	5	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:40368869C>T	uc002omp.3	-	28	12487	c.12479G>A	c.(12478-12480)GGT>GAT	p.G4160D		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4160	VWFD 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGTGAGCACACCGTTCACCTG	0.637													25	217					0	0	0	0	T	40368869	T	T	40368869	3	4	8	1	0	0	0	0	1	0	0	0	5810	507	18	4	3774	4	FCGBP	19	40368869	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1515707	40368869	18760114	542	2431											
GSK3A	2931	broad.mit.edu	37	chr19	42737444	42737444	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccccgcccctcaccttgatGatctccaccagctggtccac	6	8	7	20	1	2	2	1	2	1	0	4	2	3	2	8	1	1	1	8	1	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:42737444G>A	uc002otb.1	-	7	1115	c.996C>T	c.(994-996)ATC>ATT	p.I332I	GSK3A_uc002ota.1_Silent_p.I250I|GSK3A_uc002otc.2_RNA	NM_019884	NP_063937	P49840	GSK3A_HUMAN	glycogen synthase kinase 3 alpha	332	Protein kinase.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of transferase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process	beta-catenin destruction complex|cytosol	ATP binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|tau-protein kinase activity			ovary(2)|lung(2)	4		Prostate(69;0.00682)				TCACCTTGATGATCTCCACCA	0.642													4	10					0	0	0	0	A	42737444	A	A	42737444	2	1	8	1	0	0	0	0	0	0	0	1	6862	1280	45	2		2	GSK3A	19	42737444	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2368575	42737444	16391539	543	2432											
GEMIN7	79760	broad.mit.edu	37	chr19	45593559	45593559	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgggcacgagccgcccttCgggagcgttacctccgcagc	6	5	14	16	6	0	0	0	0	0	0	2	2	1	1	4	2	5	3	4	2	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:45593559C>T	uc002pap.1	+	3	338	c.187C>T	c.(187-189)CGG>TGG	p.R63W	uc002pas.2_5'Flank|GEMIN7_uc002paq.1_Missense_Mutation_p.R63W|GEMIN7_uc002par.1_Missense_Mutation_p.R63W	NM_001007270	NP_001007271	Q9H840	GEMI7_HUMAN	gemin 7	63					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		AGCCGCCCTTCGGGAGCGTTA	0.632													4	57					0	0	0	0	T	45593559	T	T	45593559	3	4	8	1	0	0	0	0	1	0	0	0	6370	875	31	1	189	1	GEMIN7	19	45593559	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2856115	45593559	13535424	544	2433											
PPM1N	147699	broad.mit.edu	37	chr19	46002055	46002055	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcgacggccacggtggggctCgagctgcccgcttcggtgca	4	7	16	14	6	0	0	0	0	0	0	3	2	0	0	2	5	3	4	2	5	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:46002055C>G	uc002pce.2	+	1	325	c.325C>G	c.(325-327)CGA>GGA	p.R109G	RTN2_uc002pcb.2_5'Flank|RTN2_uc002pcc.2_5'Flank|RTN2_uc002pcd.2_5'Flank|PPM1N_uc002pcf.2_5'Flank	NM_001080401	NP_001073870	Q8N819	PPM1N_HUMAN	protein phosphatase 1B-like	109	PP2C-like.						magnesium ion binding|manganese ion binding|phosphoprotein phosphatase activity				0						CGGTGGGGCTCGAGCTGCCCG	0.711													2	3					0	0	0	0	G	46002055	G	G	46002055	3	3	8	1	0	0	0	0	1	0	0	0	12406	876	31	3	327	3	PPM1N	19	46002055	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	408496	46002055	13126928	545	2434											
STRN4	29888	broad.mit.edu	37	chr19	47226133	47226133	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catgtcatacaagacggtgtCgccagagcggaaggaggcca	12	5	14	10	3	1	2	1	0	0	2	2	4	1	4	2	4	2	0	2	4	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:47226133C>T	uc002pfl.2	-	14	1873	c.1840G>A	c.(1840-1842)GAC>AAC	p.D614N	STRN4_uc002pfm.2_Missense_Mutation_p.D621N|STRN4_uc010xyf.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	614	WD 4.					cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		AAGACGGTGTCGCCAGAGCGG	0.637													29	99					0	0	0	0	T	47226133	T	T	47226133	3	4	8	1	0	0	0	0	1	0	0	0	15397	884	31	1	437	1	STRN4	19	47226133	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1224078	47226133	11902850	546	2435											
SLC1A5	6510	broad.mit.edu	37	chr19	47278850	47278850	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggagggggtttccttcctCagtggggactggcagcggat	6	9	18	8	1	1	0	1	0	0	0	3	4	3	3	2	7	1	2	2	7	0	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:47278850C>T	uc002pfs.2	-	8	2163	c.1543G>A	c.(1543-1545)GAG>AAG	p.E515K	SLC1A5_uc010xyh.1_Missense_Mutation_p.E313K|SLC1A5_uc002pfq.2_Missense_Mutation_p.E339K|SLC1A5_uc002pfr.2_Missense_Mutation_p.E287K	NM_005628	NP_005619	Q15758	AAAT_HUMAN	solute carrier family 1 member 5 isoform 1	515					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity				0		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	TTTCCTTCCTCAGTGGGGACT	0.582													53	201					0	0	0	0	T	47278850	T	T	47278850	3	4	8	1	0	0	0	0	1	0	0	0	14500	835	29	2	86	2	SLC1A5	19	47278850	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	52717	47278850	11850133	547	2436											
EHD2	30846	broad.mit.edu	37	chr19	48229328	48229328	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggtgctgcgcgtctacatCggctccttctggtcccagcc	4	10	12	15	3	2	0	0	0	2	0	5	1	4	0	3	3	4	2	3	3	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:48229328C>T	uc002phj.3	+	4	1012	c.762C>T	c.(760-762)ATC>ATT	p.I254I	EHD2_uc010xyu.1_Silent_p.I118I|EHD2_uc010xyv.1_5'Flank	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	254					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		GCGTCTACATCGGCTCCTTCT	0.697													6	6					0	0	0	0	T	48229328	T	T	48229328	2	4	8	1	0	0	0	0	0	0	0	1	5000	874	31	1		1	EHD2	19	48229328	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	950478	48229328	10899655	548	2437											
MYH14	79784	broad.mit.edu	37	chr19	50721024	50721024	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggggcctatcggagcatgctGcagggtgagtgctgggtggg	5	8	21	7	1	0	1	0	1	0	0	1	2	0	2	1	6	4	4	1	6	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:50721024G>T	uc002prr.1	+	3	605	c.558G>T	c.(556-558)CTG>CTT	p.L186L	MYH14_uc010enu.1_Silent_p.L186L|MYH14_uc002prq.1_Silent_p.L186L	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	186	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GGAGCATGCTGCAGGGTGAGT	0.642													29	57					7.01153e-11	7.36366e-11	1	0	T	50721024	T	T	50721024	2	4	8	1	0	0	0	0	0	0	0	1	10086	1306	46	4		4	MYH14	19	50721024	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	2491696	50721024	8407959	549	2438											
SIGLEC8	27181	broad.mit.edu	37	chr19	51958028	51958028	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacttgtgatacaggtcttGaggtgcctgcagatggattg	8	13	13	7	0	2	3	1	2	1	1	2	4	2	4	1	3	3	1	1	3	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:51958028G>C	uc002pwt.2	-	5	1125	c.1058C>G	c.(1057-1059)TCA>TGA	p.S353*	SIGLEC8_uc010yda.1_Nonsense_Mutation_p.S244*|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Nonsense_Mutation_p.S260*	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	353	Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TACAGGTCTTGAGGTGCCTGC	0.547													11	97					0	0	0	0	C	51958028	C	C	51958028	4	2	8	1	0	0	0	0	0	1	0	0	14379	1294	45	2	453	2	SIGLEC8	19	51958028	Nonsense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1237004	51958028	7170955	550	2439											
ZNF350	59348	broad.mit.edu	37	chr19	52468574	52468574	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctaaaggctttcccacattCactacattcaaagggtttct	11	13	6	11	0	3	0	2	0	1	0	4	0	4	0	1	2	1	3	1	2	4	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:52468574C>G	uc002pyd.2	-	5	1360	c.1132G>C	c.(1132-1134)GAA>CAA	p.E378Q	uc002pyb.2_Intron|uc002pyc.2_Intron	NM_021632	NP_067645	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	378	C2H2-type 7.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(1)	1		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		TTCCCACATTCACTACATTCA	0.433													11	43					0	0	0	0	G	52468574	G	G	52468574	3	3	8	1	0	0	0	0	1	0	0	0	17930	835	29	2	470	2	ZNF350	19	52468574	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	510546	52468574	6660409	551	2440											
ZNF615	284370	broad.mit.edu	37	chr19	52497896	52497896	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccagagctccttttctggtTttcaaaacttaaatttgatt	10	17	6	8	0	2	2	1	1	1	1	3	2	3	2	2	1	2	2	2	1	4	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:52497896T>A	uc002pye.1	-	6	725	c.433A>T	c.(433-435)AAC>TAC	p.N145Y	ZNF615_uc002pyf.1_Missense_Mutation_p.N156Y|ZNF615_uc002pyg.1_Missense_Mutation_p.N37Y|ZNF615_uc002pyh.1_Missense_Mutation_p.N156Y|ZNF615_uc010epi.1_Missense_Mutation_p.N152Y|ZNF615_uc010ydg.1_Missense_Mutation_p.N150Y	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CTTTTCTGGTTTTCAAAACTT	0.318													8	87					0	0	0	0	A	52497896	A	A	52497896	3	1	8	1	0	0	0	0	1	0	0	0	18107	1841	64	5	1766	5	ZNF615	19	52497896	Missense_Mutation	SNP	T	TCGA-BA-5152-01A-02D-1870-08	29322	52497896	6631087	552	2441											
OSCAR	126014	broad.mit.edu	37	chr19	54600369	54600369	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttggggtgcccggcatctCaaggtcacgttgaccccagg	6	8	15	12	2	2	1	2	1	1	0	3	1	2	1	3	6	1	3	3	6	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:54600369C>G	uc002qdd.2	-	4	345	c.228G>C	c.(226-228)TTG>TTC	p.L76F	OSCAR_uc002qcy.2_Missense_Mutation_p.L55F|OSCAR_uc002qcz.2_Missense_Mutation_p.L51F|OSCAR_uc002qda.2_Missense_Mutation_p.L55F|OSCAR_uc002qdb.2_Missense_Mutation_p.L40F|OSCAR_uc010erc.2_Missense_Mutation_p.E19Q|OSCAR_uc002qdc.2_Missense_Mutation_p.L65F	NM_206818	NP_996554	Q8IYS5	OSCAR_HUMAN	osteoclast-associated receptor isoform 1	51	Ig-like 1.					extracellular region|integral to membrane|plasma membrane	receptor activity				0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)					CCCGGCATCTCAAGGTCACGT	0.592													28	122					0	0	0	0	G	54600369	G	G	54600369	3	3	8	1	0	0	0	0	1	0	0	0	11339	825	29	2	844	2	OSCAR	19	54600369	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2102473	54600369	4528614	553	2442											
NLRP5	126206	broad.mit.edu	37	chr19	56539850	56539850	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccaagagatgagtccgctGaggcatgtcctgtggtccct	7	10	12	12	1	0	3	0	2	0	1	4	4	4	3	4	2	0	2	4	2	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:56539850G>A	uc002qmj.2	+	7	2251	c.2251G>A	c.(2251-2253)GAG>AAG	p.E751K	NLRP5_uc002qmi.2_Missense_Mutation_p.E732K	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	751	LRR 2.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGAGTCCGCTGAGGCATGTCC	0.522													58	202					0	0	0	0	A	56539850	A	A	56539850	3	1	8	1	0	0	0	0	1	0	0	0	10534	1291	45	2	2277	2	NLRP5	19	56539850	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1939481	56539850	2589133	554	2443											
USP29	57663	broad.mit.edu	37	chr19	57642360	57642360	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaccctcaatcagtctacaGaattaagacttcaaaaggct	16	9	6	10	0	4	3	3	0	1	3	4	3	4	3	1	1	1	1	1	1	6	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:57642360G>A	uc002qny.2	+	4	2673	c.2317G>A	c.(2317-2319)GAA>AAA	p.E773K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	773					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCAGTCTACAGAATTAAGACT	0.463													17	24					0	0	0	0	A	57642360	A	A	57642360	3	1	8	1	0	0	0	0	1	0	0	0	17127	943	33	2	2319	2	USP29	19	57642360	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1102510	57642360	1486623	555	2444											
TRIM28	10155	broad.mit.edu	37	chr19	59060728	59060728	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cggaggctgccattggagccCctcctactgccactgagggc	6	7	13	15	1	0	1	0	1	0	0	1	3	1	3	5	4	4	1	5	4	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:59060728C>A	uc002qtg.1	+	13	1982	c.1693C>A	c.(1693-1695)CCT>ACT	p.P565T	TRIM28_uc010eut.1_Missense_Mutation_p.P483T|TRIM28_uc002qth.1_Missense_Mutation_p.P180T	NM_005762	NP_005753	Q13263	TIF1B_HUMAN	tripartite motif-containing 28 protein	565					epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CATTGGAGCCCCTCCTACTGC	0.607													53	195					6.56871e-35	7.08703e-35	1	0	A	59060728	A	A	59060728	3	1	8	1	0	0	0	0	1	0	0	0	16569	623	22	4	1743	4	TRIM28	19	59060728	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1418368	59060728	68255	556	2445											
NSFL1C	55968	broad.mit.edu	37	chr20	1426360	1426360	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcccgccgtctgcaagccGaatttggatgtttgtggtag	6	12	12	11	3	1	0	0	0	1	0	2	2	2	1	4	2	2	3	4	2	3	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:1426360G>A	uc002wfc.2	-	8	1849	c.901C>T	c.(901-903)CGG>TGG	p.R301W	NSFL1C_uc002wfd.2_Missense_Mutation_p.R190W|NSFL1C_uc002wfe.2_Missense_Mutation_p.R270W|NSFL1C_uc002wff.2_RNA|NSFL1C_uc010gag.2_Missense_Mutation_p.R67W	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	301	UBX.					chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						TCTGCAAGCCGAATTTGGATG	0.517													26	258					0	0	0	0	A	1426360	A	A	1426360	3	1	8	1	0	0	0	0	1	0	0	0	10726	1057	37	1	219	1	NSFL1C	20	1426360	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08		1426360	61599160	557	2446											
ZNF343	79175	broad.mit.edu	37	chr20	2474452	2474452	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttatgattttgggtcaatttCttcatagtctctacattttc	8	21	5	7	0	4	1	2	1	2	0	6	1	4	1	0	1	1	0	0	1	4	9			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:2474452C>T	uc002wge.1	-	3	578	c.90G>A	c.(88-90)AAG>AAA	p.K30K	ZNF343_uc010gao.1_Silent_p.K30K|ZNF343_uc002wgd.1_5'Flank	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	30					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GGGTCAATTTCTTCATAGTCT	0.458													35	154					0	0	0	0	T	2474452	T	T	2474452	2	4	8	1	0	0	0	0	0	0	0	1	17925	912	32	2		2	ZNF343	20	2474452	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1048092	2474452	60551068	558	2447											
ZNF343	79175	broad.mit.edu	37	chr20	2474463	2474463	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtcaatttcttcatagtctCtacattttccccattctttg	7	19	4	11	0	5	0	2	0	3	0	7	0	6	0	2	1	1	0	2	1	3	8			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:2474463C>G	uc002wge.1	-	3	567	c.79G>C	c.(79-81)GAG>CAG	p.E27Q	ZNF343_uc010gao.1_Missense_Mutation_p.E27Q|ZNF343_uc002wgd.1_5'Flank	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E27K(1)		upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTCATAGTCTCTACATTTTCC	0.473													36	161					0	0	0	0	G	2474463	G	G	2474463	3	3	8	1	0	0	0	0	1	0	0	0	17925	922	32	2	1736	2	ZNF343	20	2474463	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	11	2474463	60551057	559	2448											
ATRN	8455	broad.mit.edu	37	chr20	3529964	3529964	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggatatatgttcaaccactCagattataacatggttctag	14	13	7	7	0	3	1	2	0	1	1	3	2	3	2	1	2	2	2	1	2	6	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:3529964C>G	uc002wim.2	+	6	1181	c.1091C>G	c.(1090-1092)TCA>TGA	p.S364*	ATRN_uc002wil.2_Nonsense_Mutation_p.S364*	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	364	Extracellular (Potential).|Kelch 1.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						TTCAACCACTCAGATTATAAC	0.299													21	99					0	0	0	0	G	3529964	G	G	3529964	4	3	8	1	0	0	0	0	0	1	0	0	1208	838	29	2	1113	2	ATRN	20	3529964	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1055501	3529964	59495556	560	2449											
C20orf185	359710	broad.mit.edu	37	chr20	31647253	31647253	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgggatttggggtgcagctGagcctgcacaccaaagtggg	8	7	16	10	1	0	1	0	1	0	0	0	2	0	2	3	4	4	3	3	4	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:31647253G>A	uc002wym.1	+	3	351	c.351G>A	c.(349-351)CTG>CTA	p.L117L		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	117	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						GGGTGCAGCTGAGCCTGCACA	0.582													13	24					0	0	0	0	A	31647253	A	A	31647253	2	1	8	1	0	0	0	0	0	0	0	1	2107	1277	45	2		2	C20orf185	20	31647253	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	28117289	31647253	31378267	561	2450											
TGM2	7052	broad.mit.edu	37	chr20	36789876	36789876	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctcgtagttgcggccctCaaagtgcagggtcagccaga	8	7	14	12	2	2	1	2	0	0	1	3	1	2	1	3	3	3	3	3	3	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:36789876C>T	uc002xhr.2	-	2	236	c.136G>A	c.(136-138)GAG>AAG	p.E46K	TGM2_uc010zvx.1_Missense_Mutation_p.E46K|TGM2_uc010zvy.1_Intron|TGM2_uc002xhs.1_Missense_Mutation_p.E46K|TGM2_uc002xht.2_Missense_Mutation_p.E46K|TGM2_uc002xhu.3_Missense_Mutation_p.E46K	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	46					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	TTGCGGCCCTCAAAGTGCAGG	0.557													9	72					0	0	0	0	T	36789876	T	T	36789876	3	4	8	1	0	0	0	0	1	0	0	0	15896	835	29	2	2007	2	TGM2	20	36789876	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5142623	36789876	26235644	562	2451											
ADA	100	broad.mit.edu	37	chr20	43251500	43251500	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgttttcctgccgcagcctGttataaagggcctggtcttc	6	14	10	11	1	1	0	0	0	1	0	3	0	2	0	4	2	2	3	4	2	3	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:43251500G>A	uc002xmj.2	-	8	878	c.750C>T	c.(748-750)AAC>AAT	p.N250N	ADA_uc010ggt.2_RNA	NM_000022	NP_000013	P00813	ADA_HUMAN	adenosine deaminase	250					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			pancreas(2)|ovary(1)	3		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	GCCGCAGCCTGTTATAAAGGG	0.557									Adenosine_Deaminase_Deficiency				27	133					0	0	0	0	A	43251500	A	A	43251500	2	1	8	1	0	0	0	0	0	0	0	1	230	1368	48	4		4	ADA	20	43251500	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	6461624	43251500	19774020	563	2452											
NEURL2	140825	broad.mit.edu	37	chr20	44517447	44517447	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgggcaggtggagcccatCaatggccagccggtgcacca	8	7	14	12	1	1	0	1	0	0	0	1	1	1	1	4	5	3	2	4	5	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:44517447C>A	uc002xqg.1	-	2	1079	c.808G>T	c.(808-810)GAT>TAT	p.D270Y	C20orf165_uc002xqf.2_5'Flank|CTSA_uc002xqh.2_5'Flank|CTSA_uc002xqj.3_5'Flank|CTSA_uc002xqi.2_5'Flank|CTSA_uc010zxi.1_5'Flank|CTSA_uc002xqk.3_5'Flank	NM_080749	NP_542787	Q9BR09	NEUL2_HUMAN	neuralized-like protein 2	270	SOCS box.				intracellular signal transduction						0		Myeloproliferative disorder(115;0.0122)				TGGAGCCCATCAATGGCCAGC	0.542													5	73					0.000602214	0.000612553	1	0	A	44517447	A	A	44517447	3	1	8	1	0	0	0	0	1	0	0	0	10400	826	29	2	53	2	NEURL2	20	44517447	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1265947	44517447	18508073	564	2453											
RBM38	55544	broad.mit.edu	37	chr20	55982766	55982766	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagtacccatacgccgcctCgcctgccacggctgccagct	6	6	9	20	4	0	0	0	0	0	0	1	0	0	0	7	1	5	3	7	1	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:55982766C>T	uc010zzj.1	+	4	759	c.584C>T	c.(583-585)TCG>TTG	p.S195L	RBM38_uc010zzk.1_3'UTR	NM_017495	NP_059965	Q9H0Z9	RBM38_HUMAN	RNA-binding region containing protein 1 isoform	195					3'-UTR-mediated mRNA stabilization|cell cycle|cell cycle arrest|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mRNA processing|negative regulation of cell proliferation|regulation of RNA splicing|RNA splicing	cytosol|cytosol|nucleus|nucleus	mRNA 3'-UTR binding|mRNA binding|nucleotide binding|RNA binding				0	Lung NSC(12;0.00242)|all_lung(29;0.00767)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.55e-12)|Epithelial(14;9.49e-09)|all cancers(14;5.01e-08)			TACGCCGCCTCGCCTGCCACG	0.692													8	20					0	0	0	0	T	55982766	T	T	55982766	3	4	8	1	0	0	0	0	1	0	0	0	13197	893	31	1	357	1	RBM38	20	55982766	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	11465319	55982766	7042754	565	2454											
YTHDF1	54915	broad.mit.edu	37	chr20	61846954	61846954	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatcttgtccttttgttctCtgcaccgccgcaggccggga	4	14	10	13	3	2	0	0	0	2	0	4	1	3	1	4	2	1	3	4	2	1	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:61846954C>G	uc002yeh.2	-	2	322	c.28_splice	c.e2-1	p.R10_splice		NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1											ovary(2)	2						CTTTTGTTCTCTGCACCGCCG	0.622													17	29					0	0	0	0	G	61846954	G	G	61846954	5	3	8	1	0	0	0	0	0	0	1	0	17566	927	32	2	1668	2	YTHDF1	20	61846954	Splice_Site	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5864188	61846954	1178566	566	2455											
KCNQ2	3785	broad.mit.edu	37	chr20	62038284	62038284	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtcccgcaggttcccctCggggggcctgcagcccgggg	2	6	17	16	3	0	0	0	0	0	0	3	0	2	0	5	6	2	4	5	6	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:62038284C>A	uc002yey.1	-	17	2509	c.2332G>T	c.(2332-2334)GAG>TAG	p.E778*	KCNQ2_uc002yez.1_Nonsense_Mutation_p.E747*|KCNQ2_uc002yfa.1_Nonsense_Mutation_p.E760*|KCNQ2_uc002yfb.1_Nonsense_Mutation_p.E750*	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	778	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	AGGTTCCCCTCGGGGGGCCTG	0.701													4	10					5.9392e-07	6.17364e-07	1	0	A	62038284	A	A	62038284	4	1	8	1	0	0	0	0	0	1	0	0	8122	893	31	3	290	3	KCNQ2	20	62038284	Nonsense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	191330	62038284	987236	567	2456											
PRIC285	85441	broad.mit.edu	37	chr20	62203596	62203596	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggcctcctgagagtggcagGtgaccaagcaggccgggcag	9	4	17	11	1	0	2	0	2	0	1	1	3	1	2	4	5	1	3	4	5	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:62203596G>C	uc002yfm.2	-	2	1035	c.143C>G	c.(142-144)ACC>AGC	p.T48S	PRIC285_uc002yfn.2_Missense_Mutation_p.T48S	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	48	C2H2-type; atypical.				cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			AGAGTGGCAGGTGACCAAGCA	0.706													9	7					0	0	0	0	C	62203596	C	C	62203596	3	2	8	1	0	0	0	0	1	0	0	0	12547	1261	44	4	7905	4	PRIC285	20	62203596	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	165312	62203596	821924	568	2457											
CXADR	1525	broad.mit.edu	37	chr21	18931416	18931416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagtggcaaaaattgtctGactcacagaaaatgcccact	15	9	8	9	0	2	3	1	2	1	1	2	3	2	3	1	1	1	1	1	1	4	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr21:18931416G>A	uc002yki.2	+	4	656	c.538G>A	c.(538-540)GAC>AAC	p.D180N	CXADR_uc002ykh.1_Missense_Mutation_p.D180N|CXADR_uc010gld.1_Intron|CXADR_uc010gle.1_Intron|CXADR_uc002ykj.1_Missense_Mutation_p.D153N	NM_001338	NP_001329	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	180	Extracellular (Potential).|Ig-like C2-type 2.				blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			ovary(1)	1				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		AAAATTGTCTGACTCACAGAA	0.383													18	68					0	0	0	0	A	18931416	A	A	18931416	3	1	8	1	0	0	0	0	1	0	0	0	4093	1290	45	2	552	2	CXADR	21	18931416	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08		18931416	29198479	569	2458											
KRTAP15-1	254950	broad.mit.edu	37	chr21	31812732	31812732	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttccacttataatttgttCtaccccagcaatgccatcta	10	15	4	12	0	2	0	0	0	2	0	3	0	3	0	4	0	3	3	4	0	5	7	rs138157793	byFrequency	TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr21:31812732C>G	uc002yod.2	+	1	87	c.87C>G	c.(85-87)TTC>TTG	p.F29L		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	29						intermediate filament					0						ATAATTTGTTCTACCCCAGCA	0.478													3	111					0	0	0	0	G	31812732	G	G	31812732	3	3	8	1	0	0	0	0	1	0	0	0	8565	912	32	2	89	2	KRTAP15-1	21	31812732	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	12881316	31812732	16317163	570	2459											
SON	6651	broad.mit.edu	37	chr21	34931614	34931614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtttcggatgaagaggaaGaagaacctcctttttatcat	13	13	9	6	1	1	4	1	1	0	3	3	6	2	6	2	2	1	1	2	2	5	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr21:34931614G>A	uc002yse.1	+	5	6449	c.6400G>A	c.(6400-6402)GAA>AAA	p.E2134K	SON_uc002ysc.2_Missense_Mutation_p.E2134K|SON_uc002ysd.2_Missense_Mutation_p.E1125K|SON_uc002ysf.1_Missense_Mutation_p.E162K|SON_uc002ysg.2_Missense_Mutation_p.E1125K	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	2134					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TGAAGAGGAAGAAGAACCTCC	0.323													11	143					0	0	0	0	A	34931614	A	A	34931614	3	1	8	1	0	0	0	0	1	0	0	0	14990	943	33	2	6418	2	SON	21	34931614	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	3118882	34931614	13198281	571	2460											
DSCAM	1826	broad.mit.edu	37	chr21	41684117	41684117	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttggaaatcctcaaggagctCgtgaagtcaatattgtcaat	13	12	9	7	1	3	1	3	1	0	0	5	3	4	3	1	2	1	1	1	2	6	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr21:41684117C>G	uc002yyq.1	-	9	2405	c.1953G>C	c.(1951-1953)ACG>ACC	p.T651T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	651	Extracellular (Potential).|Ig-like C2-type 7.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCAAGGAGCTCGTGAAGTCAA	0.547													20	78					0	0	0	0	G	41684117	G	G	41684117	2	3	8	1	0	0	0	0	0	0	0	1	4790	871	31	3		3	DSCAM	21	41684117	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	6752503	41684117	6445778	572	2461											
UFD1L	7353	broad.mit.edu	37	chr22	19463117	19463117	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atagggtggtcgaacatgttGaaagagaactagaaggagga	16	7	15	3	1	0	3	0	1	0	2	1	7	0	5	0	4	2	1	0	4	6	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:19463117G>C	uc002zpm.2	-	2	142	c.12C>G	c.(10-12)TTC>TTG	p.F4L	UFD1L_uc002zpo.2_Missense_Mutation_p.F4L|UFD1L_uc011agy.1_Missense_Mutation_p.F4L|UFD1L_uc002zpp.2_5'UTR|UFD1L_uc010grq.2_5'UTR	NM_005659	NP_005650	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1-like isoform A	4					skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity				0	Colorectal(54;0.0993)					CGAACATGTTGAAAGAGAACT	0.423													14	61					0	0	0	0	C	19463117	C	C	19463117	3	2	8	1	0	0	0	0	1	0	0	0	17003	1281	45	2	955	2	UFD1L	22	19463117	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08		19463117	31841449	573	2462											
DGCR8	54487	broad.mit.edu	37	chr22	20079432	20079432	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gggaaatccgaggtctgcatCctgcacgagtacatgcagcg	10	7	13	11	3	1	0	0	0	1	0	3	3	3	1	2	2	5	4	2	2	2	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:20079432C>G	uc002zri.2	+	7	1895	c.1545C>G	c.(1543-1545)ATC>ATG	p.I515M	DGCR8_uc010grz.2_Missense_Mutation_p.I515M|DGCR8_uc002zrj.2_Missense_Mutation_p.I158M	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	515	Necessary for interaction with DROSHA.|Necessary for heme-binding and pri-miRNA processing.|DRBM 1.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					AGGTCTGCATCCTGCACGAGT	0.468													10	34					0	0	0	0	G	20079432	G	G	20079432	3	3	8	1	0	0	0	0	1	0	0	0	4486	845	30	2	1567	2	DGCR8	22	20079432	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	616315	20079432	31225134	574	2463											
TRMT2A	27037	broad.mit.edu	37	chr22	20102116	20102116	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggaagaaggcgtgtggaGagatccggaaggtcagccct	10	6	16	9	2	1	2	1	0	0	2	2	6	2	5	3	5	1	0	3	5	3	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:20102116G>C	uc002zrk.1	-	8	1429	c.1214C>G	c.(1213-1215)TCT>TGT	p.S405C	TRMT2A_uc002zrl.1_Missense_Mutation_p.S405C|TRMT2A_uc002zrm.1_Missense_Mutation_p.S227C|TRMT2A_uc002zrn.1_Missense_Mutation_p.S405C|RANBP1_uc011ahl.1_5'Flank|RANBP1_uc002zro.1_5'Flank|RANBP1_uc002zrp.2_5'Flank	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	405					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						GGCGTGTGGAGAGATCCGGAA	0.632													21	98					0	0	0	0	C	20102116	C	C	20102116	3	2	8	1	0	0	0	0	1	0	0	0	16632	942	33	2	687	2	TRMT2A	22	20102116	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	22684	20102116	31202450	575	2464											
ZNF280B	140883	broad.mit.edu	37	chr22	22843165	22843165	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccatccctgagtttagcccTtttgggatttatgctgttta	6	18	8	9	0	0	1	0	1	0	0	2	2	2	2	3	1	2	3	3	1	3	8			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:22843165T>C	uc002zwc.1	-	4	1335	c.559A>G	c.(559-561)AGG>GGG	p.R187G	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGTTTAGCCCTTTTGGGATTT	0.388													4	189					0	0	0	0	C	22843165	C	C	22843165	3	2	8	1	0	0	0	0	1	0	0	0	17882	1608	56	5	1076	5	ZNF280B	22	22843165	Missense_Mutation	SNP	T	TCGA-BA-5152-01A-02D-1870-08	2741049	22843165	28461401	576	2465											
BCR	613	broad.mit.edu	37	chr22	23523385	23523385	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgatggggcttccggcgcGcggcgcaggcccccgacggc	4	3	18	16	8	0	0	0	0	0	0	1	2	1	0	3	6	1	2	3	6	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:23523385G>A	uc002zww.2	+	1	834	c.238G>A	c.(238-240)GCG>ACG	p.A80T	BCR_uc002zwx.2_Missense_Mutation_p.A80T	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	80	Kinase.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12						CTTCCGGCGCGCGGCGCAGGC	0.736			T	ABL1| FGFR1|JAK2 	CML|ALL|AML								3	4					0	0	0	0	A	23523385	A	A	23523385	3	1	8	1	0	0	0	0	1	0	0	0	1390	1087	38	1	240	1	BCR	22	23523385	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	680220	23523385	27781181	577	2466											
ASPHD2	57168	broad.mit.edu	37	chr22	26829810	26829810	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttcgtgtggtactgttatCacgtgggcagggagcagccc	6	11	14	10	2	2	0	1	0	1	0	3	1	2	1	1	3	3	4	1	3	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:26829810C>G	uc003acg.2	+	2	626	c.229C>G	c.(229-231)CAC>GAC	p.H77D		NM_020437	NP_065170	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	77	Helical; (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			ovary(1)	1						GTACTGTTATCACGTGGGCAG	0.637													23	74					0	0	0	0	G	26829810	G	G	26829810	3	3	8	1	0	0	0	0	1	0	0	0	1057	826	29	2	231	2	ASPHD2	22	26829810	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3306425	26829810	24474756	578	2467											
TBC1D10A	83874	broad.mit.edu	37	chr22	30691787	30691787	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgccggtgcaggtcacgctCaatcacgtccagccacttgg	7	8	11	15	3	3	0	3	0	0	0	4	0	4	0	3	3	3	2	3	3	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:30691787C>T	uc011akt.1	-	4	487	c.463G>A	c.(463-465)GAG>AAG	p.E155K	GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_RNA|GATSL3_uc003ahh.2_RNA|GATSL3_uc010gvq.2_RNA|GATSL3_uc003ahi.2_Missense_Mutation_p.E13K|TBC1D10A_uc003ahj.3_Missense_Mutation_p.E67K|TBC1D10A_uc010gvu.2_Missense_Mutation_p.E162K|TBC1D10A_uc003ahk.3_Missense_Mutation_p.E155K	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	155	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						AGGTCACGCTCAATCACGTCC	0.617													9	48					0	0	0	0	T	30691787	T	T	30691787	3	4	8	1	0	0	0	0	1	0	0	0	15664	835	29	2	1087	2	TBC1D10A	22	30691787	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	3861977	30691787	20612779	579	2468											
TRIOBP	11078	broad.mit.edu	37	chr22	38119504	38119504	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggaaacctccagggcctcatCcacccaagaggacaccccta	12	4	8	17	0	1	1	1	0	0	1	3	3	3	3	7	3	1	0	7	3	3	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:38119504C>T	uc003atr.2	+	7	1212	c.941C>T	c.(940-942)TCC>TTC	p.S314F	TRIOBP_uc003atu.2_Missense_Mutation_p.S142F|TRIOBP_uc003atq.1_Missense_Mutation_p.S314F|TRIOBP_uc003ats.1_Missense_Mutation_p.S142F	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	314					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					AGGGCCTCATCCACCCAAGAG	0.607													62	159					0	0	0	0	T	38119504	T	T	38119504	3	4	8	1	0	0	0	0	1	0	0	0	16620	855	30	2	959	2	TRIOBP	22	38119504	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	7427717	38119504	13185062	580	2469											
H1F0	3005	broad.mit.edu	37	chr22	38202088	38202088	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaaaaaggccaaaccagtGaaacccaaagcaaagtccag	19	2	7	13	0	0	1	0	1	0	0	1	1	1	1	5	1	3	1	5	1	6	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:38202088G>A	uc003aty.2	+	1	975	c.537G>A	c.(535-537)GTG>GTA	p.V179V	GCAT_uc003atz.2_5'Flank|GCAT_uc003aua.1_5'Flank	NM_005318	NP_005309	P07305	H10_HUMAN	H1 histone family, member 0	179					DNA fragmentation involved in apoptotic nuclear change|nucleosome assembly	actin cytoskeleton|Golgi apparatus|nucleoplasm|nucleosome	DNA binding				0	Melanoma(58;0.045)					CCAAACCAGTGAAACCCAAAG	0.502													19	44					0	0	0	0	A	38202088	A	A	38202088	2	1	8	1	0	0	0	0	0	0	0	1	6959	1277	45	2		2	H1F0	22	38202088	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	82584	38202088	13102478	581	2470											
C22orf23	84645	broad.mit.edu	37	chr22	38349119	38349119	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggcggcgccggaacccagttCctttggtcactacctccatc	6	9	10	16	3	1	0	1	0	0	0	4	1	3	1	5	4	2	1	5	4	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:38349119C>G	uc003auj.1	-	2	129	c.38G>C	c.(37-39)GGA>GCA	p.G13A	C22orf23_uc003auk.1_Missense_Mutation_p.G13A|POLR2F_uc010gxi.2_5'Flank|POLR2F_uc003aul.2_5'Flank|POLR2F_uc003aum.2_5'Flank	NM_032561	NP_115950	Q9BZE7	EVG1_HUMAN	hypothetical protein LOC84645	13											0	Melanoma(58;0.045)					GAACCCAGTTCCTTTGGTCAC	0.522													39	143					0	0	0	0	G	38349119	G	G	38349119	3	3	8	1	0	0	0	0	1	0	0	0	2147	855	30	2	639	2	C22orf23	22	38349119	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	147031	38349119	12955447	582	2471											
DMC1	11144	broad.mit.edu	37	chr22	38945946	38945946	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacaaagtattttctgtatCaatgaagataatctttcctc	13	17	4	7	0	3	2	1	1	2	1	5	2	4	2	1	0	1	2	1	0	7	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:38945946C>G	uc003avz.1	-	8	653	c.478G>C	c.(478-480)GAT>CAT	p.D160H	DMC1_uc011anv.1_Intron|DMC1_uc003awa.1_Missense_Mutation_p.D160H	NM_007068	NP_008999	Q14565	DMC1_HUMAN	DMC1 dosage suppressor of mck1 homolog	160					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)					TTTTCTGTATCAATGAAGATA	0.328								Homologous_recombination					8	40					0	0	0	0	G	38945946	G	G	38945946	3	3	8	1	0	0	0	0	1	0	0	0	4601	826	29	2	572	2	DMC1	22	38945946	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	596827	38945946	12358620	583	2472											
SUN2	25777	broad.mit.edu	37	chr22	39138314	39138314	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccacctcctacctggatgcGagcagcagtttccctgcgga	7	9	10	15	2	0	0	0	0	0	0	3	3	3	2	5	2	5	3	5	2	1	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:39138314G>A	uc003awh.1	-	10	1344	c.1060C>T	c.(1060-1062)CGC>TGC	p.R354C	SUN2_uc011anz.1_Missense_Mutation_p.R389C|SUN2_uc011aoa.1_Missense_Mutation_p.R343C|SUN2_uc003awi.1_Missense_Mutation_p.R354C|SUN2_uc010gxq.1_Missense_Mutation_p.R375C|SUN2_uc010gxr.1_Missense_Mutation_p.R354C|SUN2_uc010gxs.1_Missense_Mutation_p.R354C	NM_015374	NP_056189	Q9UH99	SUN2_HUMAN	unc-84 homolog B	354	Potential.|Perinuclear space.				centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			large_intestine(1)|skin(1)	2						ACCTGGATGCGAGCAGCAGTT	0.607													9	43					0	0	0	0	A	39138314	A	A	39138314	3	1	8	1	0	0	0	0	1	0	0	0	15458	1058	37	1	1133	1	SUN2	22	39138314	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	192368	39138314	12166252	584	2473											
L3MBTL2	83746	broad.mit.edu	37	chr22	41613186	41613186	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcacagttacaaggctgctCccgtcagctgtttcaagcac	10	10	8	13	1	3	0	3	0	0	0	4	0	4	0	1	1	4	6	1	1	3	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:41613186C>T	uc003azo.2	+	5	634	c.580C>T	c.(580-582)CCC>TCC	p.P194S	L3MBTL2_uc010gyi.1_Missense_Mutation_p.P103S|L3MBTL2_uc003azn.2_RNA|uc003azp.1_RNA	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	194	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						CAAGGCTGCTCCCGTCAGCTG	0.632													25	54					0	0	0	0	T	41613186	T	T	41613186	3	4	8	1	0	0	0	0	1	0	0	0	8632	855	30	2	598	2	L3MBTL2	22	41613186	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	2474872	41613186	9691380	585	2474											
L3MBTL2	83746	broad.mit.edu	37	chr22	41613200	41613200	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgctcccgtcagctgtttCaagcacgtgagtgccctgga	6	10	12	13	2	2	1	2	1	0	0	3	2	3	2	2	1	4	5	2	1	1	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:41613200C>T	uc003azo.2	+	5	648	c.594C>T	c.(592-594)TTC>TTT	p.F198F	L3MBTL2_uc010gyi.1_Silent_p.F107F|L3MBTL2_uc003azn.2_RNA|uc003azp.1_RNA	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	198	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						TCAGCTGTTTCAAGCACGTGA	0.627													20	51					0	0	0	0	T	41613200	T	T	41613200	2	4	8	1	0	0	0	0	0	0	0	1	8632	825	29	2		2	L3MBTL2	22	41613200	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	14	41613200	9691366	586	2475											
POLR3H	171568	broad.mit.edu	37	chr22	41925317	41925317	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccaccaggagagaaggccCaggcctggctcactgatgga	10	5	14	12	0	1	2	1	1	0	1	2	5	2	4	4	5	0	1	4	5	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:41925317C>T	uc003baf.2	-	7	645	c.585G>A	c.(583-585)CTG>CTA	p.L195L	POLR3H_uc003bae.2_RNA|POLR3H_uc003bag.2_Silent_p.L195L|POLR3H_uc003bai.2_Silent_p.L166L	NM_138338	NP_612211	Q9Y535	RPC8_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	195					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			skin(1)	1						AGAGAAGGCCCAGGCCTGGCT	0.597													9	34					0	0	0	0	T	41925317	T	T	41925317	2	4	8	1	0	0	0	0	0	0	0	1	12291	581	21	4		4	POLR3H	22	41925317	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	312117	41925317	9379249	587	2476											
ASMTL	8623	broad.mit.edu	37	chrX	1546743	1546743	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtcccgcctctcccgcctCggccttctcatcgcggctgc	1	10	9	21	5	2	0	1	0	2	0	7	0	3	0	5	2	1	1	5	2	0	1			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:1546743C>T	uc004cpx.1	-	7	892	c.781G>A	c.(781-783)GAG>AAG	p.E261K	ASMTL_uc011mhe.1_Missense_Mutation_p.E185K|ASMTL_uc004cpy.1_Missense_Mutation_p.E245K|ASMTL_uc011mhf.1_Missense_Mutation_p.E203K	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	261					melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTCCCGCCTCGGCCTTCTCA	0.697													7	57					0	0	0	0	T	1546743	T	T	1546743	3	4	8	1	0	0	0	0	1	0	0	0	1048	893	31	1	1112	1	ASMTL	23	1546743	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08		1546743	153723817	588	2477											
TBL1X	6907	broad.mit.edu	37	chrX	9679750	9679750	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgtctatagcgtagctttCagccctgatgggaagtactt	8	13	10	10	1	2	1	1	1	1	0	2	2	2	2	2	1	4	3	2	1	5	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:9679750C>T	uc010ndq.2	+	16	1907	c.1539C>T	c.(1537-1539)TTC>TTT	p.F513F	TBL1X_uc004csq.3_Silent_p.F462F|TBL1X_uc010ndr.2_Silent_p.F462F|TBL1X_uc004csr.2_Silent_p.F513F|TBL1X_uc004css.2_Silent_p.F464F	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	513	WD 7.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				GCGTAGCTTTCAGCCCTGATG	0.527													15	21					0	0	0	0	T	9679750	T	T	9679750	2	4	8	1	0	0	0	0	0	0	0	1	15705	825	29	2		2	TBL1X	23	9679750	Silent	SNP	C	TCGA-BA-5152-01A-02D-1870-08	8133007	9679750	145590810	589	2478											
CDKL5	6792	broad.mit.edu	37	chrX	18646649	18646649	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgagccaggcctctggcggGagcagcaacatccggcagga	9	4	15	13	2	1	1	0	1	1	0	2	3	2	3	3	5	4	3	3	5	1	0			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:18646649G>A	uc004cym.2	+	18	2908	c.2655G>A	c.(2653-2655)GGG>GGA	p.G885G	CDKL5_uc004cyn.2_Silent_p.G885G	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	885					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					CCTCTGGCGGGAGCAGCAACA	0.592													43	47					0	0	0	0	A	18646649	A	A	18646649	2	1	8	1	0	0	0	0	0	0	0	1	3172	1161	41	2		2	CDKL5	23	18646649	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8966899	18646649	136623911	590	2479											
SH3KBP1	30011	broad.mit.edu	37	chrX	19764535	19764535	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctttgttggtgagagggtCtttcttcatctctttcttta	5	20	9	7	0	5	1	1	1	4	1	6	2	5	1	0	2	1	2	0	2	1	7			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:19764535C>T	uc004czm.2	-	3	503	c.187G>A	c.(187-189)GAC>AAC	p.D63N	SH3KBP1_uc004czl.2_Missense_Mutation_p.D26N	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	63					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						GTGAGAGGGTCTTTCTTCATC	0.403													54	51					0	0	0	0	T	19764535	T	T	19764535	3	4	8	1	0	0	0	0	1	0	0	0	14320	913	32	2	1890	2	SH3KBP1	23	19764535	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1117886	19764535	135506025	591	2480											
OTUD5	55593	broad.mit.edu	37	chrX	48783269	48783269	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcttctagcatctgctgttCaatccatgactcctccgatg	7	14	7	13	1	4	1	1	1	3	0	7	2	7	1	3	0	2	3	3	0	2	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:48783269C>G	uc004dlu.2	-	6	1193	c.1132G>C	c.(1132-1134)GAA>CAA	p.E378Q	OTUD5_uc004dlt.3_Missense_Mutation_p.E373Q|OTUD5_uc004dlv.2_Missense_Mutation_p.E373Q|OTUD5_uc011mmp.1_Missense_Mutation_p.E156Q	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	378					negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						ATCTGCTGTTCAATCCATGAC	0.507													8	45					0	0	0	0	G	48783269	G	G	48783269	3	3	8	1	0	0	0	0	1	0	0	0	11369	835	29	2	599	2	OTUD5	23	48783269	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	29018734	48783269	106487291	592	2481											
CCNB3	85417	broad.mit.edu	37	chrX	50094305	50094305	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccccttggtcagacagctGaacaaactgctgactttcag	11	9	8	13	0	2	3	2	2	0	1	2	3	2	3	2	1	4	2	2	1	2	2			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:50094305G>A	uc004dox.3	+	12	4324	c.4026G>A	c.(4024-4026)CTG>CTA	p.L1342L	CCNB3_uc004doy.2_Silent_p.L1342L|CCNB3_uc004doz.2_Silent_p.L238L|CCNB3_uc010njq.2_Silent_p.L234L|CCNB3_uc004dpa.2_Silent_p.L181L	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1342					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TCAGACAGCTGAACAAACTGC	0.458													71	49					0	0	0	0	A	50094305	A	A	50094305	2	1	8	1	0	0	0	0	0	0	0	1	2929	1277	45	2		2	CCNB3	23	50094305	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	1311036	50094305	105176255	593	2482											
EFNB1	1947	broad.mit.edu	37	chrX	68058466	68058466	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccttctgggcaggttcctGagtgggaagggcttggtgat	5	13	16	7	0	1	2	0	2	1	0	3	3	3	3	2	5	0	3	2	5	1	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:68058466G>A	uc004dxd.3	+	2	915	c.135G>A	c.(133-135)CTG>CTA	p.L45L	EFNB1_uc004dxe.2_Silent_p.L45L	NM_004429	NP_004420	P98172	EFNB1_HUMAN	ephrin-B1 precursor	45	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding				0						GCAGGTTCCTGAGTGGGAAGG	0.592													17	11					0	0	0	0	A	68058466	A	A	68058466	2	1	8	1	0	0	0	0	0	0	0	1	4977	1277	45	2		2	EFNB1	23	68058466	Silent	SNP	G	TCGA-BA-5152-01A-02D-1870-08	17964161	68058466	87212094	594	2483											
DGAT2L6	347516	broad.mit.edu	37	chrX	69424864	69424864	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaagacagtagacaagtatCacgcactctacatcagtgcc	15	7	8	11	1	3	3	2	0	1	3	3	3	3	3	1	0	2	3	1	0	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:69424864C>G	uc004dxx.1	+	7	1019	c.922C>G	c.(922-924)CAC>GAC	p.H308D		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	308					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						AGACAAGTATCACGCACTCTA	0.468													18	18					0	0	0	0	G	69424864	G	G	69424864	3	3	8	1	0	0	0	0	1	0	0	0	4481	826	29	2	948	2	DGAT2L6	23	69424864	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	1366398	69424864	85845696	595	2484											
NAP1L3	4675	broad.mit.edu	37	chrX	92927287	92927287	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaggctaacatccgacaaGaacttcagaatgggctcatc	13	9	8	11	1	3	2	3	0	0	2	5	3	4	2	1	2	2	2	1	2	4	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:92927287G>C	uc004efq.2	-	1	1322	c.1017C>G	c.(1015-1017)TTC>TTG	p.F339L	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	339					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						CATCCGACAAGAACTTCAGAA	0.423													14	27					0	0	0	0	C	92927287	C	C	92927287	3	2	8	1	0	0	0	0	1	0	0	0	10211	933	33	2	507	2	NAP1L3	23	92927287	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	23502423	92927287	62343273	596	2485											
GUCY2F	2986	broad.mit.edu	37	chrX	108625366	108625366	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccttgagctctgttcttcctCgaagctccacttcatagccc	6	13	6	16	1	3	1	1	1	2	0	6	2	5	1	4	0	3	3	4	0	2	5			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:108625366C>G	uc004eod.3	-	17	3407	c.3131G>C	c.(3130-3132)CGA>CCA	p.R1044P	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	1044	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TGTTCTTCCTCGAAGCTCCAC	0.423													3	166					0	0	0	0	G	108625366	G	G	108625366	3	3	8	1	0	0	0	0	1	0	0	0	6937	884	31	3	207	3	GUCY2F	23	108625366	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	15698079	108625366	46645194	597	2486											
WDR44	54521	broad.mit.edu	37	chrX	117530989	117530989	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actggagaagaaatacctttGagtcttgcagaagagaaact	16	9	10	6	0	1	5	0	1	1	4	1	7	1	5	1	1	3	1	1	1	5	3			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:117530989G>C	uc004eqn.2	+	7	1535	c.1110G>C	c.(1108-1110)TTG>TTC	p.L370F	WDR44_uc004eqo.2_Missense_Mutation_p.L370F|WDR44_uc011mtr.1_Missense_Mutation_p.L345F|WDR44_uc010nqi.2_Missense_Mutation_p.L80F	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	370						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						AAATACCTTTGAGTCTTGCAG	0.363													33	42					0	0	0	0	C	117530989	C	C	117530989	3	2	8	1	0	0	0	0	1	0	0	0	17364	1281	45	2	1136	2	WDR44	23	117530989	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	8905623	117530989	37739571	598	2487											
ODZ1	10178	broad.mit.edu	37	chrX	123514646	123514646	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacgtgattcttttcctcttCgacagttgtcccataccgga	7	14	7	13	3	2	1	0	1	2	0	5	3	4	2	3	1	1	1	3	1	1	6			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:123514646C>G	uc004euj.2	-	31	7982	c.7918G>C	c.(7918-7920)GAA>CAA	p.E2640Q	ODZ1_uc011muj.1_Missense_Mutation_p.E2646Q|ODZ1_uc010nqy.2_Missense_Mutation_p.E2647Q	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2640	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTTTCCTCTTCGACAGTTGTC	0.532													3	83					0	0	0	0	G	123514646	G	G	123514646	3	3	8	1	0	0	0	0	1	0	0	0	10888	893	31	3	263	3	ODZ1	23	123514646	Missense_Mutation	SNP	C	TCGA-BA-5152-01A-02D-1870-08	5983657	123514646	31755914	599	2488											
EMD	2010	broad.mit.edu	37	chrX	153608306	153608306	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcctttcaatccagacttGaattcgactagaggggatgc	10	11	9	11	1	1	3	1	1	0	2	4	5	3	4	3	2	1	0	3	2	3	4			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:153608306G>C	uc004fkl.2	+	3	440	c.192G>C	c.(190-192)TTG>TTC	p.L64F		NM_000117	NP_000108	P50402	EMD_HUMAN	emerin	64	Interaction with F-actin (Probable).				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATCCAGACTTGAATTCGACTA	0.567													69	100					0	0	0	0	C	153608306	C	C	153608306	3	2	8	1	0	0	0	0	1	0	0	0	5111	1281	45	2	202	2	EMD	23	153608306	Missense_Mutation	SNP	G	TCGA-BA-5152-01A-02D-1870-08	30093660	153608306	1662254	600	2489											
APITD1	378708	broad.mit.edu	37	chr1	10494743	10494743	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaaagaccttgaaatgtttGcaaggtgggtagagaacttg	13	10	12	6	0	0	3	0	1	0	2	0	4	0	3	2	2	2	3	2	2	5	4			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:10494743G>A	uc001are.2	+	3	621	c.205G>A	c.(205-207)GCA>ACA	p.A69T	APITD1_uc001arf.2_Missense_Mutation_p.A69T|APITD1_uc001arg.2_3'UTR|APITD1_uc001arh.2_Missense_Mutation_p.A30T	NM_199294	NP_954988	Q8N2Z9	CENPS_HUMAN	apoptosis-inducing, TAF9-like domain 1 isoform	69					DNA repair|mitotic prometaphase|transcription initiation, DNA-dependent	chromosome, centromeric region|cytosol|Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		TGAAATGTTTGCAAGGTGGGT	0.418													8	162					0	0	0	0	A	10494743	A	A	10494743	3	1	9	1	0	0	0	0	1	0	0	0	775	1319	46	4	215	4	APITD1	1	10494743	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08		10494743	238755878	1	2490											
EIF4G3	8672	broad.mit.edu	37	chr1	21220080	21220080	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtaaagtctggtcctcgaGgcaaaattcgaggatccaga	12	9	12	8	2	1	1	0	0	1	1	5	4	3	2	2	3	0	2	2	3	4	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:21220080G>C	uc001bec.2	-	13	2271	c.2015C>G	c.(2014-2016)CCT>CGT	p.P672R	EIF4G3_uc010odi.1_Missense_Mutation_p.P276R|EIF4G3_uc010odj.1_Missense_Mutation_p.P671R|EIF4G3_uc009vpz.2_Missense_Mutation_p.P392R|EIF4G3_uc001bed.2_Missense_Mutation_p.P672R|EIF4G3_uc001bef.2_Missense_Mutation_p.P671R|EIF4G3_uc001bee.2_Missense_Mutation_p.P678R	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	672					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TGGTCCTCGAGGCAAAATTCG	0.463													46	83					0	0	0	0	C	21220080	C	C	21220080	3	2	9	1	0	0	0	0	1	0	0	0	5062	1000	35	4	2822	4	EIF4G3	1	21220080	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	10725337	21220080	228030541	2	2491											
PPP1R8	5511	broad.mit.edu	37	chr1	28167531	28167531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttggttattcccagcacacgGcactttcttgggtcacattc	7	14	8	12	1	2	0	1	0	1	0	4	0	3	0	1	3	1	3	1	3	1	6			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:28167531G>A	uc001bov.1	+	4	332	c.278G>A	c.(277-279)GGC>GAC	p.G93D	PPP1R8_uc001bow.1_5'UTR|PPP1R8_uc001box.1_Intron|PPP1R8_uc009vtc.1_RNA|PPP1R8_uc009vtd.1_Intron	NM_014110	NP_054829	Q12972	PP1R8_HUMAN	protein phosphatase 1 regulatory inhibitor	93	FHA.|Interaction with CDC5L, SF3B1 and MELK.				mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|RNA splicing|transcription, DNA-dependent	cytoplasm|nuclear speck|spliceosomal complex	DNA binding|endonuclease activity|protein binding|protein serine/threonine phosphatase inhibitor activity|ribonuclease E activity|RNA binding				0		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.76e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00248)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGCACACGGCACTTTCTTG	0.468													5	250					0	0	0	0	A	28167531	A	A	28167531	3	1	9	1	0	0	0	0	1	0	0	0	12437	1203	42	4	292	4	PPP1R8	1	28167531	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	6947451	28167531	221083090	3	2492											
HIVEP3	59269	broad.mit.edu	37	chr1	42046335	42046335	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacttaacccagaagggccGggcccaacctcatgcacatc	11	6	8	16	1	2	1	2	0	0	1	3	1	2	1	4	2	3	1	4	2	3	1			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:42046335G>A	uc001cgz.3	-	4	5347	c.4134C>T	c.(4132-4134)CCC>CCT	p.P1378P	HIVEP3_uc001cha.3_Silent_p.P1378P|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1378					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CAGAAGGGCCGGGCCCAACCT	0.527													105	134					0	0	0	0	A	42046335	A	A	42046335	2	1	9	1	0	0	0	0	0	0	0	1	7227	1103	39	1		1	HIVEP3	1	42046335	Silent	SNP	G	TCGA-BA-5153-01A-01D-1434-08	13878804	42046335	207204286	4	2493											
C1orf114	57821	broad.mit.edu	37	chr1	169391468	169391468	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgcaaagatttgtcaggAtcagaatgccgtttggtgtg	9	13	12	7	1	2	2	2	0	0	2	3	3	3	3	2	2	2	2	2	2	2	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:169391468A>T	uc001gga.1	-	3	369	c.201T>A	c.(199-201)GAT>GAA	p.D67E	C1orf114_uc001gfz.1_Missense_Mutation_p.D67E|C1orf114_uc009wvq.1_Missense_Mutation_p.D67E|C1orf114_uc001ggb.2_Missense_Mutation_p.D67E|C1orf114_uc001ggc.1_Missense_Mutation_p.D67E	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	67											0	all_hematologic(923;0.208)					ATTTGTCAGGATCAGAATGCC	0.383													45	83					0	0	0	0	T	169391468	T	T	169391468	3	4	9	1	0	0	0	0	1	0	0	0	1996	330	12	5	1341	5	C1orf114	1	169391468	Missense_Mutation	SNP	A	TCGA-BA-5153-01A-01D-1434-08	127345133	169391468	79859153	5	2494											
C1orf49	84066	broad.mit.edu	37	chr1	178491563	178491563	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgccccaaagtcccagacTgagggaaggtgaagcttaac	12	6	11	12	0	0	3	0	2	0	1	1	4	1	4	4	2	3	1	4	2	4	1			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr1:178491563T>A	uc001glt.1	+	9	802	c.690T>A	c.(688-690)ACT>ACA	p.T230T	C1orf49_uc001glu.1_3'UTR|C1orf49_uc001glv.1_Intron|C1orf49_uc001glw.1_Intron	NM_032126	NP_115502	Q5T0J7	CA049_HUMAN	hypothetical protein LOC84066	230						microtubule cytoskeleton					0						agtcccagactgagggaaggt	0.04													10	13					0	0	0	0	A	178491563	A	A	178491563	2	1	9	1	0	0	0	0	0	0	0	1	2051	1567	55	5		5	C1orf49	1	178491563	Silent	SNP	T	TCGA-BA-5153-01A-01D-1434-08	9100095	178491563	70759058	6	2495											
SEMA4F	10505	broad.mit.edu	37	chr2	74883774	74883774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgcccgggacaccatcttcGctttatccctgcccttctca	5	11	7	18	3	2	0	1	0	2	0	5	1	3	1	4	1	1	1	4	1	1	4			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:74883774G>A	uc002sna.1	+	2	370	c.259G>A	c.(259-261)GCT>ACT	p.A87T	SEMA4F_uc010ysb.1_Missense_Mutation_p.A87T|SEMA4F_uc010ffq.1_Missense_Mutation_p.A87T|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Missense_Mutation_p.A87T	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	87	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CACCATCTTCGCTTTATCCCT	0.527													68	131					0	0	0	0	A	74883774	A	A	74883774	3	1	9	1	0	0	0	0	1	0	0	0	14100	1087	38	1	265	1	SEMA4F	2	74883774	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08		74883774	168315599	7	2496											
C2orf68	388969	broad.mit.edu	37	chr2	85836569	85836569	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggcgtacctgatagacgaTaactgatgtgacctctccac	11	9	9	12	2	1	4	0	3	1	1	2	5	1	4	3	1	2	1	3	1	3	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:85836569T>A	uc002sqc.2	-	3	439	c.367A>T	c.(367-369)ATC>TTC	p.I123F	USP39_uc002sqb.2_Intron|USP39_uc010ysu.1_5'Flank|USP39_uc010ysv.1_5'Flank	NM_001013649	NP_001013671	Q2NKX9	CB068_HUMAN	hypothetical protein LOC388969	123										central_nervous_system(1)	1						TGATAGACGATAACTGATGTG	0.542													170	299					0	0	0	0	A	85836569	A	A	85836569	3	1	9	1	0	0	0	0	1	0	0	0	2197	1406	49	5	141	5	C2orf68	2	85836569	Missense_Mutation	SNP	T	TCGA-BA-5153-01A-01D-1434-08	10952795	85836569	157362804	8	2497											
TTN	7273	broad.mit.edu	37	chr2	179568957	179568957	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttctgctcgaacatctgcaAtggtcaatttatggactttg	9	15	8	9	1	3	0	1	0	2	0	4	2	3	1	0	2	3	2	0	2	4	4			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:179568957A>G	uc010zfg.1	-	103	26632	c.26408T>C	c.(26407-26409)ATT>ACT	p.I8803T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.I5464T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9730							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACATCTGCAATGGTCAATTT	0.413													91	181					0	0	0	0	G	179568957	G	G	179568957	3	3	9	1	0	0	0	0	1	0	0	0	16803	101	4	5	74417	5	TTN	2	179568957	Missense_Mutation	SNP	A	TCGA-BA-5153-01A-01D-1434-08	93732388	179568957	63630416	9	2498											
MARS2	92935	broad.mit.edu	37	chr2	198571571	198571571	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccgtgtccagctgtgtccGgcaaactaatggttttgtcc	6	12	12	11	2	0	0	0	0	0	0	3	0	3	0	4	3	2	3	4	3	2	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:198571571G>A	uc002uuq.2	+	1	1485	c.1442G>A	c.(1441-1443)CGG>CAG	p.R481Q	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	481					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	AGCTGTGTCCGGCAAACTAAT	0.542													4	261					0	0	0	0	A	198571571	A	A	198571571	3	1	9	1	0	0	0	0	1	0	0	0	9370	1116	39	1	1444	1	MARS2	2	198571571	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	19002614	198571571	44627802	10	2499											
AGFG1	3267	broad.mit.edu	37	chr2	228416677	228416677	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcccttctcttctgtcagcgGcaacctttggcactgcatcc	5	12	8	16	1	3	0	1	0	2	0	5	0	4	0	3	2	3	3	3	2	1	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr2:228416677G>A	uc002vpc.2	+	11	1631	c.1381G>A	c.(1381-1383)GCA>ACA	p.A461T	AGFG1_uc002vpd.2_Missense_Mutation_p.A485T|AGFG1_uc002vpe.2_Missense_Mutation_p.A461T|AGFG1_uc002vpf.2_Missense_Mutation_p.A421T	NM_004504	NP_004495	P52594	AGFG1_HUMAN	HIV-1 Rev binding protein isoform 2	461					cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TCTGTCAGCGGCAACCTTTGG	0.458													4	231					0	0	0	0	A	228416677	A	A	228416677	3	1	9	1	0	0	0	0	1	0	0	0	380	1203	42	4	1499	4	AGFG1	2	228416677	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	29845106	228416677	14782696	11	2500											
PLCXD2	257068	broad.mit.edu	37	chr3	111432939	111432939	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agtgaagaccattgcccgggGcttggttgggggcctcaaga	8	8	16	9	1	1	3	1	1	0	2	1	3	1	3	3	5	1	2	3	5	2	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:111432939G>T	uc003dya.2	+	3	1416	c.830G>T	c.(829-831)GGC>GTC	p.G277V	PLCXD2_uc003dyb.2_Missense_Mutation_p.G277V|PLCXD2_uc003dxz.2_Missense_Mutation_p.G277V	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	277					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						ATTGCCCGGGGCTTGGTTGGG	0.502													6	173					3.59834e-05	3.86687e-05	1	0	T	111432939	T	T	111432939	3	4	9	1	0	0	0	0	1	0	0	0	12097	1203	42	4	840	4	PLCXD2	3	111432939	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08		111432939	86589491	12	2501											
MYLK	4638	broad.mit.edu	37	chr3	123385193	123385193	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggatgatctgagggggcattGctgagggaggacagggagaa	11	6	20	4	0	1	4	0	3	1	1	1	8	1	7	0	6	1	2	0	6	1	1			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:123385193G>A	uc003ego.2	-	22	3986	c.3704C>T	c.(3703-3705)GCA>GTA	p.A1235V	MYLK_uc010hrr.2_5'Flank|MYLK_uc011bjv.1_Missense_Mutation_p.A35V|MYLK_uc011bjw.1_Missense_Mutation_p.A1235V|MYLK_uc003egp.2_Missense_Mutation_p.A1166V|MYLK_uc003egq.2_Missense_Mutation_p.A1235V|MYLK_uc003egr.2_Missense_Mutation_p.A1166V|MYLK_uc003egs.2_Missense_Mutation_p.A1059V	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1235	Actin-binding (calcium/calmodulin- insensitive) (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		AGGGGGCATTGCTGAGGGAGG	0.557													42	166					0	0	0	0	A	123385193	A	A	123385193	3	1	9	1	0	0	0	0	1	0	0	0	10109	1333	46	4	2092	4	MYLK	3	123385193	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	11952254	123385193	74637237	13	2502											
SMC4	10051	broad.mit.edu	37	chr3	160150245	160150245	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaatgcttactttgggagggGacgccgaactcgagcttgta	10	10	13	8	3	0	0	0	0	0	0	1	4	0	2	1	3	4	3	1	3	4	4			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:160150245G>A	uc003fdh.2	+	22	3585	c.3472G>A	c.(3472-3474)GAC>AAC	p.D1158N	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.D1133N|SMC4_uc003fdj.2_Missense_Mutation_p.D1158N|SMC4_uc010hwd.2_Missense_Mutation_p.D1100N|SMC4_uc003fdl.2_Missense_Mutation_p.D861N	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1158					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TTTGGGAGGGGACGCCGAACT	0.363													8	89					0	0	0	0	A	160150245	A	A	160150245	3	1	9	1	0	0	0	0	1	0	0	0	14849	1174	41	2	3554	2	SMC4	3	160150245	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	36765052	160150245	37872185	14	2503											
MUC20	200958	broad.mit.edu	37	chr3	195452996	195452997	+	Frame_Shift_Del	DEL	AG	-	-																															ccactaacagcgccacagaaAgagaagtgacagcacccggg																										TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr3:195452996_195452997delAG	uc010hzo.2	+	3	1135_1136	c.1009_1010delAG	c.(1009-1011)AGAfs	p.R337fs	MUC20_uc010hzp.2_Frame_Shift_Del_p.R302fs|MUC20_uc011bte.1_RNA	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	508	Involved in oligomerization.		Missing.		protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CGCCACAGAAAGAGAAGTGACA	0.604													---	---	---								-	195452997	-	-	195452996	7	5	9	1	0	1	0	1	0	0	0	0	10029	64	3	0	1019	0	MUC20	3	195452996	Frame_Shift_Del	DEL	AG	TCGA-BA-5153-01A-01D-1434-08	35302751	195452996	2569434	15	2504											
FRYL	285527	broad.mit.edu	37	chr4	48529997	48529997	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgattactcactgatgggttCtttgggaggccagattctgg	7	14	13	7	0	3	3	1	2	2	1	3	4	3	4	1	4	1	1	1	4	1	4			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr4:48529997C>T	uc003gyh.1	-	52	7736	c.7131G>A	c.(7129-7131)AAG>AAA	p.K2377K	FRYL_uc003gyg.1_Silent_p.K1073K|FRYL_uc003gyi.1_Silent_p.K1265K|FRYL_uc003gyj.1_Silent_p.K672K	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2377					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CTGATGGGTTCTTTGGGAGGC	0.373													5	152					0	0	0	0	T	48529997	T	T	48529997	2	4	9	1	0	0	0	0	0	0	0	1	6098	912	32	2		2	FRYL	4	48529997	Silent	SNP	C	TCGA-BA-5153-01A-01D-1434-08		48529997	142624279	16	2505											
PCDHB3	56132	broad.mit.edu	37	chr5	140480302	140480302	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctctttgtttttctgggaggGtctctggctgggtccgagtc	2	16	14	9	1	3	0	0	0	3	0	6	2	4	1	1	4	0	2	1	4	0	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr5:140480302G>A	uc003lio.2	+	1	69	c.69G>A	c.(67-69)GGG>GGA	p.G23G	uc003lin.2_RNA	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	23					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCTGGGAGGGTCTCTGGCTG	0.498													27	75					0	0	0	0	A	140480302	A	A	140480302	2	1	9	1	0	0	0	0	0	0	0	1	11597	1248	44	4		4	PCDHB3	5	140480302	Silent	SNP	G	TCGA-BA-5153-01A-01D-1434-08		140480302	40434958	17	2506											
SLC26A2	1836	broad.mit.edu	37	chr5	149357868	149357868	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgtgacaaaagttgctatgCaattatggttggcagcactg	12	12	11	6	0	0	1	0	1	0	0	0	1	0	1	0	2	3	6	0	2	5	4			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr5:149357868C>T	uc003lrh.2	+	2	921	c.653C>T	c.(652-654)GCA>GTA	p.A218V		NM_000112	NP_000103	P50443	S26A2_HUMAN	solute carrier family 26 member 2	218	Extracellular (Potential).					integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AGTTGCTATGCAATTATGGTT	0.363													50	134					0	0	0	0	T	149357868	T	T	149357868	3	4	9	1	0	0	0	0	1	0	0	0	14581	710	25	4	655	4	SLC26A2	5	149357868	Missense_Mutation	SNP	C	TCGA-BA-5153-01A-01D-1434-08	8877566	149357868	31557392	18	2507											
OR2W1	26692	broad.mit.edu	37	chr6	29012436	29012436	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacaagaaatgatccagaaTgttgtttccacatgtgggca	14	10	9	8	0	0	3	0	1	0	2	2	3	2	3	2	1	0	3	2	1	3	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr6:29012436T>C	uc003nlw.2	-	1	517	c.517A>G	c.(517-519)ATT>GTT	p.I173V		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TGATCCAGAATGTTGTTTCCA	0.378													62	105					0	0	0	0	C	29012436	C	C	29012436	3	2	9	1	0	0	0	0	1	0	0	0	11086	1464	51	5	449	5	OR2W1	6	29012436	Missense_Mutation	SNP	T	TCGA-BA-5153-01A-01D-1434-08		29012436	142102631	19	2508											
NEU1	4758	broad.mit.edu	37	chr6	31828219	31828219	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tctcatggactcctgacctgGcattcatcaggattgaaatc	10	12	8	11	0	3	2	3	2	1	0	6	4	4	4	2	3	0	1	2	3	1	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr6:31828219G>A	uc003nxq.3	-	4	951	c.795C>T	c.(793-795)TGC>TGT	p.C265C	NEU1_uc010jtg.2_RNA|NEU1_uc003nxr.3_RNA|NEU1_uc010jth.2_Silent_p.C96C|NEU1_uc003nxs.3_Silent_p.C265C	NM_000434	NP_000425	Q99519	NEUR1_HUMAN	neuraminidase precursor	265						cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			ovary(1)	1					Oseltamivir(DB00198)|Zanamivir(DB00558)	TCCTGACCTGGCATTCATCAG	0.557													4	163					0	0	0	0	A	31828219	A	A	31828219	2	1	9	1	0	0	0	0	0	0	0	1	10395	1195	42	4		4	NEU1	6	31828219	Silent	SNP	G	TCGA-BA-5153-01A-01D-1434-08	2815783	31828219	139286848	20	2509											
KCNK5	8645	broad.mit.edu	37	chr6	39159524	39159524	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcgtggtagttggcgctgggGttcacacctgagcggacagg	6	8	18	9	3	1	1	1	1	0	0	1	2	1	2	1	6	1	4	1	6	1	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr6:39159524G>T	uc003oon.2	-	5	1006	c.642C>A	c.(640-642)AAC>AAA	p.N214K		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	214					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						TGGCGCTGGGGTTCACACCTG	0.587													65	121					4.38816e-42	4.93669e-42	1	0	T	39159524	T	T	39159524	3	4	9	1	0	0	0	0	1	0	0	0	8108	1252	44	4	861	4	KCNK5	6	39159524	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	7331305	39159524	131955543	21	2510											
CHPF2	54480	broad.mit.edu	37	chr7	150934838	150934838	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcaccggcgggccctggctCgcagggtcagcctgctgcgg	3	5	18	15	4	1	0	1	0	0	0	2	0	1	0	3	6	3	4	3	6	0	0			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr7:150934838C>T	uc003wjr.1	+	4	2903	c.1390C>T	c.(1390-1392)CGC>TGC	p.R464C	CHPF2_uc003wjq.1_Missense_Mutation_p.R456C|MIR671_hsa-mir-671|MI0003760_5'Flank	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	464	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						GGCCCTGGCTCGCAGGGTCAG	0.652													27	58					0	0	0	0	T	150934838	T	T	150934838	3	4	9	1	0	0	0	0	1	0	0	0	3384	884	31	1	1404	1	CHPF2	7	150934838	Missense_Mutation	SNP	C	TCGA-BA-5153-01A-01D-1434-08		150934838	8203825	22	2511											
FAM86B2	653333	broad.mit.edu	37	chr8	12285220	12285220	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgcggacggtaaaggccaCgtagacctcaggagcccgct	9	6	14	12	4	1	1	1	0	0	1	1	3	1	3	3	4	2	4	3	4	3	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr8:12285220C>T	uc003wvt.3	-	7	838	c.838G>A	c.(838-840)GTG>ATG	p.V280M	FAM66D_uc011kxp.1_Intron|uc003wvm.1_Intron|uc011kxs.1_5'Flank|uc003wvp.1_5'Flank|FAM86B2_uc003wvq.3_RNA|FAM86B2_uc003wvr.3_Missense_Mutation_p.V103M|FAM86B2_uc003wvs.3_Missense_Mutation_p.V180M|FAM86B2_uc010lsn.2_RNA|FAM86B2_uc003wvu.3_Missense_Mutation_p.V89M|FAM86B2_uc010lso.2_RNA|FAM86B2_uc011kxt.1_Missense_Mutation_p.V52M|FAM86B2_uc011kxu.1_RNA|FAM86B2_uc010lsl.2_RNA	NM_001137610	NP_001131082	P0C5J1	F86B2_HUMAN	hypothetical protein LOC653333	280											0						GTAAAGGCCACGTAGACCTCA	0.652													7	41					0	0	0	0	T	12285220	T	T	12285220	3	4	9	1	0	0	0	0	1	0	0	0	5677	536	19	1	162	1	FAM86B2	8	12285220	Missense_Mutation	SNP	C	TCGA-BA-5153-01A-01D-1434-08		12285220	134078802	23	2512											
RP1	6101	broad.mit.edu	37	chr8	55534066	55534066	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggagggtcacccagagcttCgaggcatttctacagcacct	10	8	11	12	1	2	1	1	0	1	1	3	3	2	2	2	3	3	3	2	3	1	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr8:55534066C>T	uc003xsd.1	+	2	688	c.540C>T	c.(538-540)TTC>TTT	p.F180F	RP1_uc011ldy.1_Silent_p.F180F	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	180	Doublecortin 2.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCCAGAGCTTCGAGGCATTTC	0.637													99	157					0	0	0	0	T	55534066	T	T	55534066	2	4	9	1	0	0	0	0	0	0	0	1	13597	883	31	1		1	RP1	8	55534066	Silent	SNP	C	TCGA-BA-5153-01A-01D-1434-08	43248846	55534066	90829956	24	2513											
PDE7A	5150	broad.mit.edu	37	chr8	66691967	66691967	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acacttacagtggaaaatacGaaaatcaatatatgggtgag	18	9	9	5	1	1	1	1	1	0	0	1	3	1	2	0	2	2	0	0	2	9	4			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr8:66691967G>A	uc003xvq.2	-	3	283	c.271C>T	c.(271-273)CGT>TGT	p.R91C	PDE7A_uc003xvr.2_Missense_Mutation_p.R91C|PDE7A_uc003xvp.2_Missense_Mutation_p.R65C	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	91						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	TGGAAAATACGAAAATCAATA	0.353													8	191					0	0	0	0	A	66691967	A	A	66691967	3	1	9	1	0	0	0	0	1	0	0	0	11705	1058	37	1	1253	1	PDE7A	8	66691967	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	11157901	66691967	79672055	25	2514											
NOV	4856	broad.mit.edu	37	chr8	120428777	120428778	+	Frame_Shift_Del	DEL	AG	-	-																															aggggaaagcctgagcatgcAgagtgtgcagagcacgagct																										TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr8:120428777_120428778delAG	uc003yoq.2	+	1	226_227	c.5_6delAG	c.(4-6)CAGfs	p.Q2fs		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	2					regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGAGCATGCAGAGTGTGCAGA	0.55											OREG0018940	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	120428778	-	-	120428777	7	5	9	1	0	1	0	1	0	0	0	0	10607	188	7	0	7	0	NOV	8	120428777	Frame_Shift_Del	DEL	AG	TCGA-BA-5153-01A-01D-1434-08	53736810	120428777	25935245	26	2515											
ASAP1	50807	broad.mit.edu	37	chr8	131130883	131130883	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttccttgaaaacctatgaTctacatactttgcagtgata	12	15	5	9	0	2	3	0	3	2	0	3	3	3	3	2	0	4	1	2	0	6	7			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr8:131130883T>G	uc003yta.1	-	18	1674	c.1646A>C	c.(1645-1647)GAT>GCT	p.D549A	ASAP1_uc003ysz.1_Missense_Mutation_p.D360A|ASAP1_uc011liw.1_Missense_Mutation_p.D542A	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	549	Arf-GAP.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						AAACCTATGATCTACATACTT	0.333													35	32					0	0	0	0	G	131130883	G	G	131130883	3	3	9	1	0	0	0	0	1	0	0	0	1012	1435	50	5	1791	5	ASAP1	8	131130883	Missense_Mutation	SNP	T	TCGA-BA-5153-01A-01D-1434-08	10702106	131130883	15233139	27	2516											
RECK	8434	broad.mit.edu	37	chr9	36110017	36110017	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttttgctggcaatttggtgtGctctacccgcctttgcctca	4	16	9	12	1	2	0	1	0	1	0	2	0	2	0	3	2	4	3	3	2	2	5			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr9:36110017G>A	uc003zyv.2	+	15	1915	c.1829G>A	c.(1828-1830)TGC>TAC	p.C610Y	RECK_uc003zyw.2_Missense_Mutation_p.C482Y|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	610						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			AATTTGGTGTGCTCTACCCGC	0.463													118	193					0	0	0	0	A	36110017	A	A	36110017	3	1	9	1	0	0	0	0	1	0	0	0	13265	1319	46	4	1887	4	RECK	9	36110017	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08		36110017	105103414	28	2517											
C9orf5	23731	broad.mit.edu	37	chr9	111795700	111795700	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaagtatgcagagaagaatAggaccgatgattgctccttc	14	9	10	8	1	0	3	0	1	0	2	2	6	1	4	2	1	2	3	2	1	5	4			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr9:111795700A>G	uc004bdt.3	-	17	2513	c.2481T>C	c.(2479-2481)CCT>CCC	p.P827P	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Silent_p.P819P	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	827	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		AGAGAAGAATAGGACCGATGA	0.527													3	186					0	0	0	0	G	111795700	G	G	111795700	2	3	9	1	0	0	0	0	0	0	0	1	2498	407	15	5		5	C9orf5	9	111795700	Silent	SNP	A	TCGA-BA-5153-01A-01D-1434-08	75685683	111795700	29417731	29	2518											
SPTAN1	6709	broad.mit.edu	37	chr9	131388129	131388129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaagatcagcttctcgccGccaaacacgttcagtccaag	12	8	7	14	3	4	1	3	0	1	1	6	1	5	1	3	0	2	2	3	0	3	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr9:131388129G>A	uc004bvl.3	+	47	6249	c.6136G>A	c.(6136-6138)GCC>ACC	p.A2046T	SPTAN1_uc004bvm.3_Missense_Mutation_p.A2051T|SPTAN1_uc004bvn.3_Missense_Mutation_p.A2026T|SPTAN1_uc010mye.1_5'Flank|SPTAN1_uc010myf.1_5'Flank	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2046	Spectrin 21.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GCTTCTCGCCGCCAAACACGT	0.582													6	314					0	0	0	0	A	131388129	A	A	131388129	3	1	9	1	0	0	0	0	1	0	0	0	15183	1087	38	1	6337	1	SPTAN1	9	131388129	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	19592429	131388129	9825302	30	2519											
PPFIBP2	8495	broad.mit.edu	37	chr11	7618879	7618879	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggacaccaggtgaaactcaAtgctgctgaagagatgcttc	13	8	11	9	0	1	3	1	2	0	1	2	5	1	4	1	2	4	3	1	2	3	1			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr11:7618879A>G	uc001mfj.3	+	5	849	c.461A>G	c.(460-462)AAT>AGT	p.N154S	PPFIBP2_uc010rbb.1_Missense_Mutation_p.N77S|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_Missense_Mutation_p.N77S|PPFIBP2_uc010rbd.1_5'UTR|PPFIBP2_uc010rbe.1_Missense_Mutation_p.N42S	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	154	Potential.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GTGAAACTCAATGCTGCTGAA	0.547													16	20					0	0	0	0	G	7618879	G	G	7618879	3	3	9	1	0	0	0	0	1	0	0	0	12369	101	4	5	475	5	PPFIBP2	11	7618879	Missense_Mutation	SNP	A	TCGA-BA-5153-01A-01D-1434-08		7618879	127387637	31	2520											
TMEM132A	54972	broad.mit.edu	37	chr11	60696185	60696185	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccacacgggccgagctggccTacacgcttgagcctgcagct	7	6	12	16	3	0	1	0	1	0	0	0	2	0	1	4	2	5	4	4	2	1	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr11:60696185T>A	uc001nqj.2	+	4	812	c.619T>A	c.(619-621)TAC>AAC	p.Y207N	TMEM132A_uc001nqi.2_Missense_Mutation_p.Y207N|TMEM132A_uc001nqk.2_Missense_Mutation_p.Y220N|TMEM132A_uc001nql.1_Missense_Mutation_p.Y220N	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	207	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CGAGCTGGCCTACACGCTTGA	0.692													28	38					0	0	0	0	A	60696185	A	A	60696185	3	1	9	1	0	0	0	0	1	0	0	0	16111	1522	53	5	633	5	TMEM132A	11	60696185	Missense_Mutation	SNP	T	TCGA-BA-5153-01A-01D-1434-08	53077306	60696185	74310331	32	2521											
DRD2	1813	broad.mit.edu	37	chr11	113283362	113283362	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catggtcttgagggaggtccGggttttgccattgggcatgg	5	12	17	7	1	1	1	0	1	1	0	2	2	2	2	2	6	1	2	2	6	0	4			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr11:113283362G>A	uc001pnz.2	-	6	1375	c.1054C>T	c.(1054-1056)CGG>TGG	p.R352W	DRD2_uc010rwv.1_Missense_Mutation_p.R351W|DRD2_uc001poa.3_Missense_Mutation_p.R352W|DRD2_uc001pob.3_Missense_Mutation_p.R323W	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	352	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	AGGGAGGTCCGGGTTTTGCCA	0.567													52	41					0	0	0	0	A	113283362	A	A	113283362	3	1	9	1	0	0	0	0	1	0	0	0	4779	1115	39	1	285	1	DRD2	11	113283362	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	52587177	113283362	21723154	33	2522											
GRIK4	2900	broad.mit.edu	37	chr11	120732824	120732824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accatgtgcccttcactgggCctgcggtaagtacccgccag	7	8	11	15	2	1	0	1	0	0	0	1	0	1	0	5	2	3	2	5	2	2	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr11:120732824C>T	uc001pxn.2	+	9	1188	c.901C>T	c.(901-903)CCT>TCT	p.P301S	GRIK4_uc009zav.1_Missense_Mutation_p.P301S|GRIK4_uc009zaw.1_Missense_Mutation_p.P301S|GRIK4_uc009zax.1_Missense_Mutation_p.P301S	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	301	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CTTCACTGGGCCTGCGGTAAG	0.562													142	232					0	0	0	0	T	120732824	T	T	120732824	3	4	9	1	0	0	0	0	1	0	0	0	6815	739	26	4	927	4	GRIK4	11	120732824	Missense_Mutation	SNP	C	TCGA-BA-5153-01A-01D-1434-08	7449462	120732824	14273692	34	2523											
OPCML	4978	broad.mit.edu	37	chr11	132527003	132527003	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgcactattaggtgaacccGggacgttttgggatgattgt	8	14	13	6	2	0	2	0	2	0	0	0	4	0	4	1	3	2	2	1	3	3	6			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr11:132527003G>A	uc001qgs.2	-	2	429	c.379C>T	c.(379-381)CGG>TGG	p.R127W	OPCML_uc001qgu.2_Missense_Mutation_p.R120W|OPCML_uc010sck.1_Missense_Mutation_p.R127W|OPCML_uc001qgt.2_Missense_Mutation_p.R127W|OPCML_uc010scl.1_Missense_Mutation_p.R86W	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	127					cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		AGGTGAACCCGGGACGTTTTG	0.502													31	87					0	0	0	0	A	132527003	A	A	132527003	3	1	9	1	0	0	0	0	1	0	0	0	10928	1115	39	1	682	1	OPCML	11	132527003	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	11794179	132527003	2479513	35	2524											
KRT2	3849	broad.mit.edu	37	chr12	53039156	53039156	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggaactggaccctctacCtccagaacctccaaaggcag	11	6	8	16	1	1	1	0	0	1	1	4	3	4	3	6	3	3	1	6	3	4	1			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr12:53039156C>A	uc001sat.2	-	9	1600	c.1567G>T	c.(1567-1569)GGT>TGT	p.G523C		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	523	Tail.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		GACCCTCTACCTCCAGAACCT	0.552													88	148					7.539e-32	8.35089e-32	1	0	A	53039156	A	A	53039156	3	1	9	1	0	0	0	0	1	0	0	0	8496	681	24	4	356	4	KRT2	12	53039156	Missense_Mutation	SNP	C	TCGA-BA-5153-01A-01D-1434-08		53039156	80812739	36	2525											
HAL	3034	broad.mit.edu	37	chr12	96379739	96379739	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacgcgatcacagaacctgtGactctctgtggaagaggtgg	10	8	14	9	2	2	3	1	1	1	2	3	6	2	4	1	3	1	0	1	3	2	0			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr12:96379739G>A	uc001tem.1	-	14	1450	c.1153C>T	c.(1153-1155)CAC>TAC	p.H385Y	HAL_uc009zti.1_RNA|HAL_uc010suw.1_Missense_Mutation_p.H177Y|HAL_uc010sux.1_Missense_Mutation_p.H385Y	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	385					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	CAGAACCTGTGACTCTCTGTG	0.418													33	40					0	0	0	0	A	96379739	A	A	96379739	3	1	9	1	0	0	0	0	1	0	0	0	6986	1290	45	2	852	2	HAL	12	96379739	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	43340583	96379739	37472156	37	2526											
SIAH3	283514	broad.mit.edu	37	chr13	46357874	46357874	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgatccaatcagccggcgCggggaggtgcatgtccgtgg	7	7	17	10	4	1	1	1	1	0	0	3	3	3	2	3	5	2	1	3	5	1	0			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr13:46357874C>T	uc001vap.2	-	2	536	c.454G>A	c.(454-456)GCG>ACG	p.A152T		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	152					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						TCAGCCGGCGCGGGGAGGTGC	0.617													27	19					0	0	0	0	T	46357874	T	T	46357874	3	4	9	1	0	0	0	0	1	0	0	0	14366	768	27	1	359	1	SIAH3	13	46357874	Missense_Mutation	SNP	C	TCGA-BA-5153-01A-01D-1434-08		46357874	68812004	38	2527											
SYNE2	23224	broad.mit.edu	37	chr14	64493344	64493344	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgccagaatagagaccatCatgaagcaggctgagagcag	15	5	13	8	0	1	4	1	2	0	3	1	7	1	4	2	1	3	3	2	1	3	1			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr14:64493344C>T	uc001xgm.2	+	42	6530	c.6300C>T	c.(6298-6300)ATC>ATT	p.I2100I	SYNE2_uc001xgl.2_Silent_p.I2100I	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2100	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TAGAGACCATCATGAAGCAGG	0.448													17	9					0	0	0	0	T	64493344	T	T	64493344	2	4	9	1	0	0	0	0	0	0	0	1	15512	816	29	2		2	SYNE2	14	64493344	Silent	SNP	C	TCGA-BA-5153-01A-01D-1434-08		64493344	42856196	39	2528											
AHNAK2	113146	broad.mit.edu	37	chr14	105414123	105414123	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccggctccctccggcacAgggccctctgggagtttcac	5	7	13	16	2	2	0	1	0	1	0	4	1	4	1	4	5	0	3	4	5	0	1			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr14:105414123A>G	uc010axc.1	-	7	7785	c.7665T>C	c.(7663-7665)CCT>CCC	p.P2555P	AHNAK2_uc001ypx.2_Silent_p.P2455P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2555						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTCCGGCACAGGGCCCTCTG	0.627													4	220					0	0	0	0	G	105414123	G	G	105414123	2	3	9	1	0	0	0	0	0	0	0	1	415	175	7	5		5	AHNAK2	14	105414123	Silent	SNP	A	TCGA-BA-5153-01A-01D-1434-08	40920779	105414123	1935417	40	2529											
ERN2	10595	broad.mit.edu	37	chr16	23713534	23713534	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgtctctgcagttccactcCccagggtgggatggaccctc	5	11	11	14	0	1	0	0	0	1	0	5	2	3	2	4	3	1	2	4	3	0	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr16:23713534C>T	uc002dma.3	-	11	1455	c.1286G>A	c.(1285-1287)GGG>GAG	p.G429E	ERN2_uc010bxp.2_Missense_Mutation_p.G429E|ERN2_uc010bxq.1_Missense_Mutation_p.G237E	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	381	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AGTTCCACTCCCCAGGGTGGG	0.617													112	190					0	0	0	0	T	23713534	T	T	23713534	3	4	9	1	0	0	0	0	1	0	0	0	5262	623	22	4	1686	4	ERN2	16	23713534	Missense_Mutation	SNP	C	TCGA-BA-5153-01A-01D-1434-08		23713534	66641219	41	2530											
CYLD	1540	broad.mit.edu	37	chr16	50820854	50820854	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caggatttacctctgaagaaAaaggtgaccatcttaactta	15	11	7	8	0	2	3	0	2	2	1	2	4	2	4	2	2	2	0	2	2	6	4			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr16:50820854A>T	uc002egp.1	+	13	2453	c.2038A>T	c.(2038-2040)AAA>TAA	p.K680*	CYLD_uc010cbs.1_Nonsense_Mutation_p.K677*|CYLD_uc002egq.1_Nonsense_Mutation_p.K677*|CYLD_uc002egr.1_Nonsense_Mutation_p.K677*|CYLD_uc002egs.1_Nonsense_Mutation_p.K677*	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	680					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				CTCTGAAGAAAAAGGTGACCA	0.358			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				37	26					0	0	0	0	T	50820854	T	T	50820854	4	4	9	1	0	0	0	0	0	1	0	0	4160	15	1	5	2080	5	CYLD	16	50820854	Nonsense_Mutation	SNP	A	TCGA-BA-5153-01A-01D-1434-08	27107320	50820854	39533899	42	2531											
IRX6	79190	broad.mit.edu	37	chr16	55361590	55361590	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcctggctcaacgagcaccGcaaaaacccctaccccacta	12	4	7	18	2	1	0	1	0	0	0	1	1	1	0	6	2	4	3	6	2	5	2	rs139251893	by1000genomes	TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr16:55361590G>A	uc002ehy.2	+	4	1039	c.506G>A	c.(505-507)CGC>CAC	p.R169H	IRX6_uc002ehx.2_Missense_Mutation_p.R169H|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	169	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						AACGAGCACCGCAAAAACCCC	0.612													3	56					0	0	0	0	A	55361590	A	A	55361590	3	1	9	1	0	0	0	0	1	0	0	0	7887	1087	38	1	520	1	IRX6	16	55361590	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	4540736	55361590	34993163	43	2532											
CDH3	1001	broad.mit.edu	37	chr16	68729271	68729271	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctactatggcgaagaggggGgtggcgaagaggaccaggtg	10	6	19	6	2	1	2	0	0	1	2	1	5	1	3	1	7	1	0	1	7	4	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr16:68729271G>A	uc002ewf.2	+	14	3248	c.2116G>A	c.(2116-2118)GGT>AGT	p.G706S	CDH3_uc010vli.1_Missense_Mutation_p.G651S	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	706	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CGAAGAGGGGGGTGGCGAAGA	0.587													14	6					0	0	0	0	A	68729271	A	A	68729271	3	1	9	1	0	0	0	0	1	0	0	0	3126	1232	43	4	2170	4	CDH3	16	68729271	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	13367681	68729271	21625482	44	2533											
SHBG	6462	broad.mit.edu	37	chr17	7533791	7533791	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcccaggacaagagcctatcGctgtcatgacctttgacctc	9	9	9	14	1	1	3	1	2	0	1	3	4	1	4	4	1	1	1	4	1	2	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr17:7533791G>A	uc002gie.2	+	2	207	c.169G>A	c.(169-171)GCT>ACT	p.A57T	SHBG_uc010cmo.2_5'UTR|SHBG_uc010cmp.2_5'UTR|SHBG_uc010cmq.2_5'UTR|SHBG_uc010cmr.2_5'UTR|SHBG_uc010cms.2_5'UTR|SHBG_uc010cmt.2_5'UTR|SHBG_uc010cmu.2_5'UTR|SAT2_uc002gib.1_5'Flank|SAT2_uc002gic.2_5'Flank|SHBG_uc010cmz.2_5'UTR|SHBG_uc010cmv.2_5'UTR|SHBG_uc010cmw.2_5'UTR|SHBG_uc010cmx.2_5'UTR|SHBG_uc010cmy.2_5'UTR|SHBG_uc002gid.3_5'UTR|SHBG_uc010cnd.2_Missense_Mutation_p.A57T|SHBG_uc010cna.2_Missense_Mutation_p.A57T|SHBG_uc010vue.1_Missense_Mutation_p.A57T|SHBG_uc010vuf.1_Missense_Mutation_p.A57T|SHBG_uc010cnb.2_Missense_Mutation_p.A57T|SHBG_uc010cnc.2_Missense_Mutation_p.A57T	NM_001040	NP_001031	P04278	SHBG_HUMAN	sex hormone-binding globulin isoform 1	57	Laminin G-like 1.				hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.?(1)			0		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	AGAGCCTATCGCTGTCATGAC	0.537													58	108					0	0	0	0	A	7533791	A	A	7533791	3	1	9	1	0	0	0	0	1	0	0	0	14334	1087	38	1	175	1	SHBG	17	7533791	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08		7533791	73661419	45	2534											
ASPSCR1	79058	broad.mit.edu	37	chr17	79954516	79954516	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacccgcagctgccccctttGttcctttctcgggtggggga	3	11	12	15	2	1	0	0	0	1	0	3	1	2	1	4	3	2	3	4	3	0	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr17:79954516G>C	uc002kcx.2	+	7	824	c.727G>C	c.(727-729)GTT>CTT	p.V243L	ASPSCR1_uc002kcw.1_Missense_Mutation_p.V243L|ASPSCR1_uc002kcy.2_Missense_Mutation_p.V243L|ASPSCR1_uc002kcz.2_Intron|ASPSCR1_uc002kda.2_Missense_Mutation_p.V166L|ASPSCR1_uc002kdb.1_Missense_Mutation_p.V166L	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	243							protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			TGCCCCCTTTGTTCCTTTCTC	0.657			T	TFE3	alveolar soft part sarcoma								20	42					0	0	0	0	C	79954516	C	C	79954516	3	2	9	1	0	0	0	0	1	0	0	0	1061	1377	48	4	753	4	ASPSCR1	17	79954516	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	72420725	79954516	1240694	46	2535											
CHMP1B	57132	broad.mit.edu	37	chr18	11851812	11851812	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtggttaagtcgatggatgCgacattgaagaccatgaatc	12	11	12	6	2	0	3	0	2	0	1	2	6	0	4	1	2	1	1	1	2	3	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr18:11851812C>T	uc002kqe.2	+	1	424	c.302C>T	c.(301-303)GCG>GTG	p.A101V	GNAL_uc002kqc.2_Intron|GNAL_uc010dkz.2_Intron|GNAL_uc002kqd.2_Intron	NM_020412	NP_065145	Q7LBR1	CHM1B_HUMAN	chromatin modifying protein 1B	101					cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding				0						TCGATGGATGCGACATTGAAG	0.532													4	194					0	0	0	0	T	11851812	T	T	11851812	3	4	9	1	0	0	0	0	1	0	0	0	3368	768	27	1	304	1	CHMP1B	18	11851812	Missense_Mutation	SNP	C	TCGA-BA-5153-01A-01D-1434-08		11851812	66225436	47	2536											
C18orf1	753	broad.mit.edu	37	chr18	13645458	13645458	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgggcatcagtgcaagcacCtgcagcagtaacgggaggat	11	6	14	10	2	1	0	1	0	0	0	2	2	1	2	1	3	5	6	1	3	2	1			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr18:13645458C>G	uc002ksa.2	+	7	1391	c.723C>G	c.(721-723)ACC>ACG	p.T241T	C18orf1_uc002ksb.2_Silent_p.T223T|C18orf1_uc002kse.2_Silent_p.T204T|C18orf1_uc002ksf.2_Silent_p.T186T|C18orf1_uc002ksg.1_Silent_p.T164T|C18orf1_uc002ksh.1_Silent_p.T183T|C18orf1_uc002ksi.1_Silent_p.T165T	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	241	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		GTGCAAGCACCTGCAGCAGTA	0.582													67	86					0	0	0	0	G	13645458	G	G	13645458	2	3	9	1	0	0	0	0	0	0	0	1	1903	668	24	4		4	C18orf1	18	13645458	Silent	SNP	C	TCGA-BA-5153-01A-01D-1434-08	1793646	13645458	64431790	48	2537											
ZNF516	9658	broad.mit.edu	37	chr18	74091731	74091731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctgacgcggtgccagatgCgtttgtgcatccacaggacc	8	8	13	12	3	0	2	0	1	0	1	1	3	1	3	3	2	4	3	3	2	0	1			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr18:74091731C>T	uc010dqx.1	-	3	2574	c.2339G>A	c.(2338-2340)CGC>CAC	p.R780H	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	780	C2H2-type 9; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GTGCCAGATGCGTTTGTGCAT	0.572													13	30					0	0	0	0	T	74091731	T	T	74091731	3	4	9	1	0	0	0	0	1	0	0	0	18027	768	27	1	1169	1	ZNF516	18	74091731	Missense_Mutation	SNP	C	TCGA-BA-5153-01A-01D-1434-08	60446273	74091731	3985517	49	2538											
GNA15	2769	broad.mit.edu	37	chr19	3148739	3148739	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgatcgaggccatggagcGgctgcagattccattcagca	10	8	12	11	2	1	2	1	1	0	1	3	4	2	3	2	3	3	3	2	3	0	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr19:3148739G>A	uc002lxf.2	+	2	554	c.296G>A	c.(295-297)CGG>CAG	p.R99Q	GNA15_uc010xhf.1_Missense_Mutation_p.R99Q	NM_002068	NP_002059	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein),	99					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		GCCATGGAGCGGCTGCAGATT	0.692													7	1					0	0	0	0	A	3148739	A	A	3148739	3	1	9	1	0	0	0	0	1	0	0	0	6540	1116	39	1	302	1	GNA15	19	3148739	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08		3148739	55980244	50	2539											
DENND1C	79958	broad.mit.edu	37	chr19	6477435	6477435	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcccagacagggactgctgaAacagattttgaagaagttcc	13	8	11	9	0	0	5	0	2	0	3	1	6	1	6	2	1	2	2	2	1	3	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr19:6477435A>G	uc002mfe.2	-	7	493	c.401T>C	c.(400-402)TTT>TCT	p.F134S	DENND1C_uc002mfb.2_5'Flank|DENND1C_uc002mfc.2_5'Flank|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Missense_Mutation_p.F90S	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	134	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						GGACTGCTGAAACAGATTTTG	0.627													19	19					0	0	0	0	G	6477435	G	G	6477435	3	3	9	1	0	0	0	0	1	0	0	0	4450	14	1	5	2072	5	DENND1C	19	6477435	Missense_Mutation	SNP	A	TCGA-BA-5153-01A-01D-1434-08	3328696	6477435	52651548	51	2540											
ZNF429	353088	broad.mit.edu	37	chr19	21719158	21719158	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttccaaaaagtgacactgagGagatatgataaacgtggaca	17	8	10	6	1	0	4	0	3	0	1	1	6	1	5	1	2	1	0	1	2	5	3			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr19:21719158G>A	uc002nqd.1	+	4	440	c.303G>A	c.(301-303)AGG>AGA	p.R101R	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGACACTGAGGAGATATGATA	0.328													5	45					0	0	0	0	A	21719158	A	A	21719158	2	1	9	1	0	0	0	0	0	0	0	1	17969	1165	41	2		2	ZNF429	19	21719158	Silent	SNP	G	TCGA-BA-5153-01A-01D-1434-08	15241723	21719158	37409825	52	2541											
KCNK15	60598	broad.mit.edu	37	chr20	43378887	43378887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggcgaacggctgaacgCggtggtgcggcgcctcctgt	4	7	17	13	6	0	1	0	1	0	0	1	2	1	1	3	5	3	1	3	5	2	0			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr20:43378887C>T	uc002xmr.2	+	2	465	c.401C>T	c.(400-402)GCG>GTG	p.A134V		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	134	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				CGGCTGAACGCGGTGGTGCGG	0.682													3	18					0	0	0	0	T	43378887	T	T	43378887	3	4	9	1	0	0	0	0	1	0	0	0	8101	768	27	1	407	1	KCNK15	20	43378887	Missense_Mutation	SNP	C	TCGA-BA-5153-01A-01D-1434-08		43378887	19646633	53	2542											
MYH9	4627	broad.mit.edu	37	chr22	36685234	36685234	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgctccatggcttcctccAgggcccgggccagcgacaga	6	7	12	16	2	1	1	0	0	1	1	4	2	4	1	5	3	2	2	5	3	0	1			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr22:36685234A>G	uc003apg.2	-	32	4685	c.4454T>C	c.(4453-4455)CTG>CCG	p.L1485P		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1485	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GGCTTCCTCCAGGGCCCGGGC	0.627			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				24	47					0	0	0	0	G	36685234	G	G	36685234	3	3	9	1	0	0	0	0	1	0	0	0	10095	188	7	5	1468	5	MYH9	22	36685234	Missense_Mutation	SNP	A	TCGA-BA-5153-01A-01D-1434-08		36685234	14619332	54	2543											
PHF5A	84844	broad.mit.edu	37	chr22	41863565	41863565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttacactcatcacatatgcGcaccagagtgcagggacgca	12	7	10	12	2	2	1	2	0	0	1	2	2	2	2	1	1	3	4	1	1	2	2			TCGA-BA-5153-01A-01D-1434-08	TCGA-BA-5153-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	363ccc6f-dab0-413e-bc42-d738ee25abcd	e35524f2-301e-42e6-b910-6803670d8ed8	g.chr22:41863565G>A	uc003bab.2	-	3	181	c.130C>T	c.(130-132)CGC>TGC	p.R44C	ACO2_uc003bac.2_5'Flank|ACO2_uc003bad.2_5'Flank	NM_032758	NP_116147	Q7RTV0	PHF5A_HUMAN	PHD-finger 5A	44					nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent	nuclear speck|U12-type spliceosomal complex|U2 snRNP	DNA binding|sequence-specific DNA binding transcription factor activity				0						TCACATATGCGCACCAGAGTG	0.493													43	60					0	0	0	0	A	41863565	A	A	41863565	3	1	9	1	0	0	0	0	1	0	0	0	11892	1087	38	1	210	1	PHF5A	22	41863565	Missense_Mutation	SNP	G	TCGA-BA-5153-01A-01D-1434-08	5178331	41863565	9441001	55	2544											
TMEM201	199953	broad.mit.edu	37	chr1	9647987	9647988	+	5'Flank	DEL	TC	-	-																															ttcttccttccttccttcttTctctctctctctctttcctt																										TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:9647987_9647988delTC	uc001apz.2	+						TMEM201_uc001apy.2_5'Flank	NM_001130924	NP_001124396	Q5SNT2	TM201_HUMAN	transmembrane protein 201 isoform 1							integral to membrane|nuclear inner membrane					0	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		cttccttctttctctctctctc	0.059													---	---	---								-	9647988	-	-	9647987	6	5	10	0	1	1	0	1	0	0	0	0	16192	1798	62	0		0	TMEM201	1	9647987	5'Flank	DEL	TC	TCGA-BA-5555-01A-01D-1512-08		9647987	239602634	1	2545											
RCC2	55920	broad.mit.edu	37	chr1	17743045	17743045	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcagaatctgtccatctttCgtcttctcaatgaagatggc	9	13	9	10	1	4	3	1	1	4	2	7	3	5	3	1	2	0	1	1	2	3	2	rs11588635	byFrequency	TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:17743045C>T	uc001bal.2	-	7	1004	c.957G>A	c.(955-957)ACG>ACA	p.T319T	RCC2_uc001bam.2_Silent_p.T319T	NM_001136204	NP_001129676	Q9P258	RCC2_HUMAN	regulator of chromosome condensation 2	319	RCC1 4.				cell division|mitotic prometaphase	chromosome, centromeric region|cytosol|microtubule|nucleolus|spindle					0		Colorectal(325;0.000147)|Breast(348;0.00122)|Renal(390;0.00145)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;7.69e-06)|COAD - Colon adenocarcinoma(227;1.19e-05)|Kidney(64;0.000189)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.0135)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)		GTCCATCTTTCGTCTTCTCAA	0.547													7	99					0	0	0	0	T	17743045	T	T	17743045	2	4	10	1	0	0	0	0	0	0	0	1	13239	871	31	1		1	RCC2	1	17743045	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	8095058	17743045	231507576	2	2546											
CAPZB	832	broad.mit.edu	37	chr1	19670883	19670884	+	Frame_Shift_Ins	INS	-	A	A																															acgatatcctttgtttttccINSaaagtagatctcgttcagcg																								rs138529514	by1000genomes	TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:19670883_19670884insA	uc010ocz.1	-	8	1214_1215	c.786_787insT	c.(784-789)TTTGGAfs	p.F262fs	CAPZB_uc001bce.2_Frame_Shift_Ins_p.F233fs|CAPZB_uc009vpk.2_Intron|CAPZB_uc001bcd.2_Frame_Shift_Ins_p.F221fs	NM_004930	NP_004921	P47756	CAPZB_HUMAN	F-actin capping protein beta subunit	233_234					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement	cytosol|F-actin capping protein complex|WASH complex	actin binding				0		Colorectal(325;3.93e-05)|Renal(390;0.000147)|all_lung(284;0.000169)|Lung NSC(340;0.000202)|Breast(348;0.000496)|Ovarian(437;0.00428)|Myeloproliferative disorder(586;0.0262)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Kidney(64;8.63e-06)|BRCA - Breast invasive adenocarcinoma(304;4.06e-05)|KIRC - Kidney renal clear cell carcinoma(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000525)|STAD - Stomach adenocarcinoma(196;0.00779)|READ - Rectum adenocarcinoma(331;0.103)|Lung(427;0.173)		TTTGTTTTTCCAAAGTAGATCT	0.327											OREG0013171	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								A	19670884	A	A	19670883	7	5	10	1	0	1	1	0	0	0	0	0	2655	603	21	0	126	0	CAPZB	1	19670883	Frame_Shift_Ins	INS	-	TCGA-BA-5555-01A-01D-1512-08	1927838	19670883	229579738	3	2547											
PHC2	1912	broad.mit.edu	37	chr1	33820075	33820075	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcatggcagtgacaatagcCtgctgatgtggtgatgggcc	8	9	16	8	0	0	3	0	3	0	0	0	3	0	3	2	4	2	3	2	4	2	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:33820075C>T	uc001bxg.1	-	8	1536	c.1482G>A	c.(1480-1482)CAG>CAA	p.Q494Q	PHC2_uc001bxh.1_Silent_p.Q466Q|PHC2_uc009vuh.1_Silent_p.Q495Q	NM_198040	NP_932157	Q8IXK0	PHC2_HUMAN	polyhomeotic-like 2 isoform a	494					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TGACAATAGCCTGCTGATGTG	0.607													43	63					0	0	0	0	T	33820075	T	T	33820075	2	4	10	1	0	0	0	0	0	0	0	1	11872	680	24	4		4	PHC2	1	33820075	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	14149192	33820075	215430546	4	2548											
DMRTB1	63948	broad.mit.edu	37	chr1	53925281	53925281	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgccagaagatcatggccgCgcagaaggtgctcaagacgc	11	4	14	12	4	2	4	2	0	0	4	2	4	2	4	2	2	1	2	2	2	3	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:53925281C>A	uc001cvq.1	+	1	210	c.155C>A	c.(154-156)GCG>GAG	p.A52E		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	52	DM.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						ATCATGGCCGCGCAGAAGGTG	0.637													4	8					0.00909568	0.00934019	1	0	A	53925281	A	A	53925281	3	1	10	1	0	0	0	0	1	0	0	0	4612	768	27	3	157	3	DMRTB1	1	53925281	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	20105206	53925281	195325340	5	2549											
SSX2IP	117178	broad.mit.edu	37	chr1	85135504	85135504	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaatttagtacagctactaTatttaactctctctttgtct	11	18	3	9	0	3	0	0	0	3	0	4	0	3	0	0	0	4	2	0	0	7	9			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:85135504T>C	uc001dkh.2	-	5	561	c.286A>G	c.(286-288)ATA>GTA	p.I96V	SSX2IP_uc001dkf.2_Missense_Mutation_p.I69V|SSX2IP_uc001dkg.2_RNA|SSX2IP_uc010orz.1_Missense_Mutation_p.I69V|SSX2IP_uc001dki.2_Missense_Mutation_p.I96V|SSX2IP_uc010osa.1_Missense_Mutation_p.I69V|SSX2IP_uc001dkj.2_Missense_Mutation_p.I96V|SSX2IP_uc009wci.2_Intron|SSX2IP_uc001dkk.1_Missense_Mutation_p.I92V	NM_014021	NP_054740	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting	96					cell adhesion	nucleus|protein complex				ovary(2)	2				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		ACAGCTACTATATTTAACTCT	0.368													67	107					0	0	0	0	C	85135504	C	C	85135504	3	2	10	1	0	0	0	0	1	0	0	0	15270	1406	49	5	1602	5	SSX2IP	1	85135504	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	31210223	85135504	164115117	6	2550											
SH3GLB1	51100	broad.mit.edu	37	chr1	87188228	87188228	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttttcctttgcaggtaatGcccttattaaatgtggagaa	11	16	8	6	0	0	1	0	0	0	1	1	2	1	1	2	2	2	2	2	2	5	6			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:87188228G>A	uc001dlw.2	+	4	675	c.349G>A	c.(349-351)GCC>ACC	p.A117T	SH3GLB1_uc001dlx.2_Missense_Mutation_p.A117T|SH3GLB1_uc001dly.2_Missense_Mutation_p.A117T|SH3GLB1_uc001dlz.2_Missense_Mutation_p.A17T	NM_016009	NP_057093	Q9Y371	SHLB1_HUMAN	SH3-containing protein SH3GLB1	117	BAR.				anti-apoptosis|filopodium assembly|signal transduction	Golgi membrane|mitochondrial outer membrane	cytoskeletal adaptor activity|protein homodimerization activity|SH3 domain binding				0		Lung NSC(277;0.209)		all cancers(265;0.0136)|Epithelial(280;0.0414)		TGCAGGTAATGCCCTTATTAA	0.308													32	189					0	0	0	0	A	87188228	A	A	87188228	3	1	10	1	0	0	0	0	1	0	0	0	14318	1319	46	4	363	4	SH3GLB1	1	87188228	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	2052724	87188228	162062393	7	2551											
CDC14A	8556	broad.mit.edu	37	chr1	100964649	100964649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaactaccagaaattaccCtgagctcaacaataatcagt	16	8	5	12	0	2	2	2	1	0	1	2	2	2	2	3	0	5	1	3	0	7	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:100964649C>T	uc001dtg.3	+	15	2074	c.1586C>T	c.(1585-1587)CCT>CTT	p.P529L	CDC14A_uc010oui.1_Missense_Mutation_p.P471L|CDC14A_uc001dtf.2_Missense_Mutation_p.P529L|CDC14A_uc009wed.1_Missense_Mutation_p.P236L|CDC14A_uc009wee.2_Missense_Mutation_p.P529L	NM_003672	NP_003663	Q9UNH5	CC14A_HUMAN	CDC14 homolog A isoform 1	529					cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		AGAAATTACCCTGAGCTCAAC	0.547													33	52					0	0	0	0	T	100964649	T	T	100964649	3	4	10	1	0	0	0	0	1	0	0	0	3071	681	24	4	1659	4	CDC14A	1	100964649	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	13776421	100964649	148285972	8	2552											
CTTNBP2NL	55917	broad.mit.edu	37	chr1	112999521	112999521	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgccacaaatttcagtcccaAgcagatcaggaccaacaagc	15	5	7	14	1	2	1	2	0	0	1	3	2	3	2	3	1	3	1	3	1	4	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:112999521A>T	uc001ebx.2	+	6	1635	c.1407A>T	c.(1405-1407)CAA>CAT	p.Q469H	CTTNBP2NL_uc001ebz.2_RNA	NM_018704	NP_061174	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	469						actin cytoskeleton	protein binding			central_nervous_system(2)|ovary(1)	3		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCAGTCCCAAGCAGATCAGG	0.552													32	123					0	0	0	0	T	112999521	T	T	112999521	3	4	10	1	0	0	0	0	1	0	0	0	4063	69	3	5	1421	5	CTTNBP2NL	1	112999521	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	12034872	112999521	136251100	9	2553											
CASQ2	845	broad.mit.edu	37	chr1	116280898	116280899	+	Missense_Mutation	DNP	CG	GA	GA																															gtttgatgtagtcttcaatgCgttcgaaggcttggacttcc																										TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:116280898_116280899CG>GA	uc001efx.3	-	4	742_743	c.478_479CG>TC	c.(478-480)CGC>TCC	p.R160S	CASQ2_uc010owu.1_Intron	NM_001232	NP_001223	O14958	CASQ2_HUMAN	cardiac calsequestrin 2 precursor	160					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GTCTTCAATGCGTTCGAAGGCT	0.446													105	211					0	0	0	0	GA	116280899	GA	GA	116280898	3	3	10	1	0	0	0	0	1	0	0	0	2693	768	27	3	752	3	CASQ2	1	116280898	Missense_Mutation	DNP	CG	TCGA-BA-5555-01A-01D-1512-08	3281377	116280898	132969723	10	2554											
NBPF10	100132406	broad.mit.edu	37	chr1	145293541	145293541	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagagaaatgttttctaactCaactggccggcttcctggcc	10	11	9	11	1	2	1	1	0	1	1	3	2	3	1	3	3	2	2	3	3	4	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:145293541C>G	uc001end.3	+	1	171	c.136C>G	c.(136-138)CAA>GAA	p.Q46E	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.Q46E|NOTCH2NL_uc010oyh.1_RNA|NBPF10_uc001emq.1_Missense_Mutation_p.Q46E	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	46											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTTTCTAACTCAACTGGCCGG	0.448													23	538					0	0	0	0	G	145293541	G	G	145293541	3	3	10	1	0	0	0	0	1	0	0	0	10246	827	29	2	138	2	NBPF10	1	145293541	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	29012643	145293541	103957080	11	2555											
GON4L	54856	broad.mit.edu	37	chr1	155747430	155747430	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacctgctgcatctgctgctGgagtctcttcctctgtgctg	3	15	10	13	0	3	0	0	0	3	0	5	1	4	1	2	1	6	5	2	1	1	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:155747430G>A	uc001flz.2	-	15	2171	c.2074C>T	c.(2074-2076)CAG>TAG	p.Q692*	GON4L_uc001fly.1_Nonsense_Mutation_p.Q692*|GON4L_uc009wrh.1_Nonsense_Mutation_p.Q692*|GON4L_uc001fma.1_Nonsense_Mutation_p.Q692*|GON4L_uc001fmb.3_5'Flank|GON4L_uc001fmc.2_Nonsense_Mutation_p.Q692*|GON4L_uc001fmd.3_Nonsense_Mutation_p.Q692*|GON4L_uc009wri.2_Nonsense_Mutation_p.Q278*|GON4L_uc009wrj.1_Nonsense_Mutation_p.Q207*|GON4L_uc001fme.2_Nonsense_Mutation_p.Q520*	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	692					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					ATCTGCTGCTGGAGTCTCTTC	0.353													91	165					0	0	0	0	A	155747430	A	A	155747430	4	1	10	1	0	0	0	0	0	1	0	0	6609	1357	47	4	4837	4	GON4L	1	155747430	Nonsense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	10453889	155747430	93503191	12	2556											
OR10R2	343406	broad.mit.edu	37	chr1	158449897	158449897	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggataaaagcctccacaCaccaatgtacttcttccttg	11	11	5	14	0	1	0	0	0	1	0	3	1	3	1	5	1	2	1	5	1	4	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:158449897C>A	uc010pik.1	+	1	230	c.230C>A	c.(229-231)ACA>AAA	p.T77K	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					AGCCTCCACACACCAATGTAC	0.433													189	345					1.4103e-80	1.88369e-80	1	0	A	158449897	A	A	158449897	3	1	10	1	0	0	0	0	1	0	0	0	10971	478	17	4	232	4	OR10R2	1	158449897	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	2702467	158449897	90800724	13	2557											
OR10Z1	128368	broad.mit.edu	37	chr1	158576337	158576337	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcctctctctgtatctaGtcactctgaccagcaatgtc	7	15	6	13	0	5	1	1	1	4	0	8	1	6	1	2	0	1	3	2	0	3	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:158576337G>C	uc010pio.1	+	1	109	c.109G>C	c.(109-111)GTC>CTC	p.V37L		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V37I(1)		pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TCTGTATCTAGTCACTCTGAC	0.498													123	315					0	0	0	0	C	158576337	C	C	158576337	3	2	10	1	0	0	0	0	1	0	0	0	10977	1029	36	4	111	4	OR10Z1	1	158576337	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	126440	158576337	90674284	14	2558											
FCRLA	84824	broad.mit.edu	37	chr1	161681106	161681106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gactcaggtgaccttctaccGagatggctcagctctgggtc	7	10	12	12	1	4	2	2	1	2	1	5	4	4	2	2	3	2	2	2	3	1	2	rs145034072		TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:161681106G>A	uc001gbe.2	+	4	652	c.410G>A	c.(409-411)CGA>CAA	p.R137Q	FCRLA_uc001gbd.2_Missense_Mutation_p.R131Q|FCRLA_uc001gbf.2_Intron|FCRLA_uc001gbg.2_Intron|FCRLA_uc009wuo.2_Intron|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	114	Ig-like C2-type 1.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			ACCTTCTACCGAGATGGCTCA	0.592													38	75					0	0	0	0	A	161681106	A	A	161681106	3	1	10	1	0	0	0	0	1	0	0	0	5832	1058	37	1	424	1	FCRLA	1	161681106	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	3104769	161681106	87569515	15	2559											
PAPPA2	60676	broad.mit.edu	37	chr1	176668369	176668369	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagctgctcttccaacacccGgtccaagccgacaccctcac	9	6	7	19	2	2	0	1	0	1	0	4	2	4	0	5	1	4	2	5	1	2	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:176668369G>T	uc001gkz.2	+	8	4044	c.2880G>T	c.(2878-2880)CCG>CCT	p.P960P	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	960					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TCCAACACCCGGTCCAAGCCG	0.572													91	281					1.19196e-48	1.51954e-48	1	0	T	176668369	T	T	176668369	2	4	10	1	0	0	0	0	0	0	0	1	11487	1103	39	3		3	PAPPA2	1	176668369	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	14987263	176668369	72582252	16	2560											
FAM5B	57795	broad.mit.edu	37	chr1	177249786	177249786	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggcccaggggctgtgcCggccagaggtggccgagtcc	4	6	18	13	2	0	1	0	0	0	1	1	2	1	1	5	6	2	2	5	6	0	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:177249786C>G	uc001glf.2	+	8	1786	c.1474C>G	c.(1474-1476)CGG>GGG	p.R492G	FAM5B_uc001glg.2_Missense_Mutation_p.R387G	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	492						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GGGGCTGTGCCGGCCAGAGGT	0.622													40	50					0	0	0	0	G	177249786	G	G	177249786	3	3	10	1	0	0	0	0	1	0	0	0	5625	643	23	3	1500	3	FAM5B	1	177249786	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	581417	177249786	72000835	17	2561											
CFHR2	3080	broad.mit.edu	37	chr1	196928027	196928027	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagatccatgtgtaatatcAcaagaaattatggaaaaata	19	11	6	5	0	2	2	2	0	0	2	3	3	3	3	1	1	0	1	1	1	8	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:196928027A>G	uc001gtq.1	+	5	707	c.630A>G	c.(628-630)TCA>TCG	p.S210S	CFHR2_uc001gtr.1_Silent_p.S86S	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	210	Sushi 4.					extracellular region				skin(2)|ovary(1)	3						GTGTAATATCACAAGAAATTA	0.274													41	75					0	0	0	0	G	196928027	G	G	196928027	2	3	10	1	0	0	0	0	0	0	0	1	3300	146	6	5		5	CFHR2	1	196928027	Silent	SNP	A	TCGA-BA-5555-01A-01D-1512-08	19678241	196928027	52322594	18	2562											
JMJD4	65094	broad.mit.edu	37	chr1	227921284	227921284	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgccgtggcggtcccgcaggGcctcttcctgccctgggggg	1	8	17	15	3	1	0	0	0	1	0	3	0	3	0	5	6	2	1	5	6	0	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:227921284G>A	uc001hrb.2	-	4	791	c.791C>T	c.(790-792)GCC>GTC	p.A264V	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_5'Flank|SNAP47_uc001hre.2_5'Flank|SNAP47_uc001hrf.2_5'Flank|LOC100130093_uc001hqx.3_RNA|LOC100130093_uc001hqy.3_RNA|JMJD4_uc001hrc.2_Missense_Mutation_p.A264V	NM_023007	NP_075383	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4 isoform 1	264	JmjC.										0		Prostate(94;0.0885)				GTCCCGCAGGGCCTCTTCCTG	0.637													4	30					0	0	0	0	A	227921284	A	A	227921284	3	1	10	1	0	0	0	0	1	0	0	0	7990	1203	42	4	612	4	JMJD4	1	227921284	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	30993257	227921284	21329337	19	2563											
TRIM67	440730	broad.mit.edu	37	chr1	231349664	231349664	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcagcagggccccacaGccttcagccacgtggacggg	8	3	15	15	2	1	0	1	0	0	0	1	1	1	1	4	4	4	3	4	4	0	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:231349664G>A	uc009xfn.1	+	9	2269	c.2227G>A	c.(2227-2229)GCC>ACC	p.A743T		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	743	B30.2/SPRY.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GGGCCCCACAGCCTTCAGCCA	0.652													30	42					0	0	0	0	A	231349664	A	A	231349664	3	1	10	1	0	0	0	0	1	0	0	0	16607	971	34	4	2261	4	TRIM67	1	231349664	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	3428380	231349664	17900957	20	2564											
OR2T1	26696	broad.mit.edu	37	chr1	248570029	248570029	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgtgcagacacagccctctAcgagacagtgatgtatgtgt	11	10	11	9	1	1	3	0	1	1	2	1	4	1	3	1	0	3	2	1	0	2	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr1:248570029A>G	uc010pzm.1	+	1	734	c.734A>G	c.(733-735)TAC>TGC	p.Y245C		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	245	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGCCCTCTACGAGACAGTG	0.493													78	86					0	0	0	0	G	248570029	G	G	248570029	3	3	10	1	0	0	0	0	1	0	0	0	11070	391	14	5	736	5	OR2T1	1	248570029	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	17220365	248570029	680592	21	2565											
TTC27	55622	broad.mit.edu	37	chr2	32891707	32891707	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttattgttttttcaggtgctTtgggaaaaagaacacggttc	10	16	10	5	1	1	1	1	0	0	1	2	2	1	2	0	3	2	3	0	3	4	7			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:32891707T>A	uc002rom.2	+	7	1042	c.811T>A	c.(811-813)TTG>ATG	p.L271M	TTC27_uc010ymx.1_Missense_Mutation_p.L221M	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	271							protein binding			central_nervous_system(1)	1						TTCAGGTGCTTTGGGAAAAAG	0.368													57	101					0	0	0	0	A	32891707	A	A	32891707	3	1	10	1	0	0	0	0	1	0	0	0	16763	1838	64	5	837	5	TTC27	2	32891707	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08		32891707	210307666	22	2566											
EPAS1	2034	broad.mit.edu	37	chr2	46603862	46603862	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcccagctggctcccaccCcaggagacgccatcatctct	7	7	9	18	1	2	1	1	0	1	1	4	2	3	1	5	3	1	2	5	3	0	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:46603862C>A	uc002ruv.2	+	9	1707	c.1219C>A	c.(1219-1221)CCA>ACA	p.P407T	EPAS1_uc002ruw.2_5'Flank	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	407					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			GGCTCCCACCCCAGGAGACGC	0.562													80	188					2.67039e-37	3.33363e-37	1	0	A	46603862	A	A	46603862	3	1	10	1	0	0	0	0	1	0	0	0	5174	623	22	4	1253	4	EPAS1	2	46603862	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	13712155	46603862	196595511	23	2567											
RTN4	57142	broad.mit.edu	37	chr2	55252252	55252252	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actcagctctgctgaaaataTagcagatggtgatctgtcct	11	12	9	9	0	3	3	1	2	2	1	4	3	4	3	1	1	3	3	1	1	4	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:55252252T>C	uc002rye.2	-	3	3281	c.2983A>G	c.(2983-2985)ATA>GTA	p.I995V	RTN4_uc002ryd.2_Missense_Mutation_p.I789V|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	995	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						GCTGAAAATATAGCAGATGGT	0.378													64	160					0	0	0	0	C	55252252	C	C	55252252	3	2	10	1	0	0	0	0	1	0	0	0	13793	1406	49	5	661	5	RTN4	2	55252252	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	8648390	55252252	187947121	24	2568											
NMS	129521	broad.mit.edu	37	chr2	101089969	101089969	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagctggcatattgtctgAgtcagtgggcacctctttct	7	13	11	10	0	4	1	1	1	3	0	4	1	4	1	1	2	2	4	1	2	1	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:101089969A>T	uc002tan.1	+	3	158	c.151A>T	c.(151-153)AGT>TGT	p.S51C		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	51					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						ATATTGTCTGAGTCAGTGGGC	0.209													16	45					0	0	0	0	T	101089969	T	T	101089969	3	4	10	1	0	0	0	0	1	0	0	0	10556	304	11	5	161	5	NMS	2	101089969	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	45837717	101089969	142109404	25	2569											
MAP4K4	9448	broad.mit.edu	37	chr2	102452401	102452401	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatgagagcactgtttctcaTtcccagaaaccctcctcccc	10	10	5	16	0	1	2	1	1	1	2	5	3	4	2	5	0	2	2	5	0	2	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:102452401T>G	uc002tbg.2	+	9	789	c.734T>G	c.(733-735)ATT>AGT	p.I245S	MAP4K4_uc002tbc.2_Missense_Mutation_p.I245S|MAP4K4_uc002tbd.2_Missense_Mutation_p.I245S|MAP4K4_uc002tbe.2_Missense_Mutation_p.I245S|MAP4K4_uc002tbf.2_Missense_Mutation_p.I245S|MAP4K4_uc010yvy.1_Missense_Mutation_p.I245S|MAP4K4_uc002tbh.2_Missense_Mutation_p.I245S|MAP4K4_uc002tbi.2_Intron|MAP4K4_uc010yvz.1_Missense_Mutation_p.I225S|MAP4K4_uc010fiw.1_Missense_Mutation_p.I87S|MAP4K4_uc002tbj.1_Missense_Mutation_p.I141S	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	245	Protein kinase.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CTGTTTCTCATTCCCAGAAAC	0.408													15	50					0	0	0	0	G	102452401	G	G	102452401	3	3	10	1	0	0	0	0	1	0	0	0	9315	1493	52	5	768	5	MAP4K4	2	102452401	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	1362432	102452401	140746972	26	2570											
SULT1C3	442038	broad.mit.edu	37	chr2	108863794	108863794	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccaagccaagcctgatgaTcttattctggcaacttaccc	10	12	6	13	0	2	2	0	2	2	0	3	2	3	2	4	1	4	1	4	1	5	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:108863794T>C	uc010ywo.1	+	1	144	c.144T>C	c.(142-144)GAT>GAC	p.D48D		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	48						cytoplasm	alcohol sulfotransferase activity			skin(1)	1						AGCCTGATGATCTTATTCTGG	0.338													19	173					0	0	0	0	C	108863794	C	C	108863794	2	2	10	1	0	0	0	0	0	0	0	1	15444	1432	50	5		5	SULT1C3	2	108863794	Silent	SNP	T	TCGA-BA-5555-01A-01D-1512-08	6411393	108863794	134335579	27	2571											
ANAPC1	64682	broad.mit.edu	37	chr2	112638249	112638249	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccaagccagcagcaccatCagaagaccataattcagaag	17	4	7	13	0	2	3	2	0	0	3	2	3	2	3	4	0	3	2	4	0	4	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:112638249C>T	uc002thi.2	-	2	401	c.154G>A	c.(154-156)GAT>AAT	p.D52N	ANAPC1_uc002thj.2_Missense_Mutation_p.D42N	NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	52					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						GCAGCACCATCAGAAGACCAT	0.473													11	57					0	0	0	0	T	112638249	T	T	112638249	3	4	10	1	0	0	0	0	1	0	0	0	598	826	29	2	5868	2	ANAPC1	2	112638249	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	3774455	112638249	130561124	28	2572											
SLC35F5	80255	broad.mit.edu	37	chr2	114501302	114501302	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcttacttttttcagtatCaatgtttgtgctctcaggtt	6	21	7	7	0	3	0	3	0	1	0	4	0	3	0	0	1	3	5	0	1	3	8			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:114501302C>A	uc002tku.1	-	6	974	c.550G>T	c.(550-552)GAT>TAT	p.D184Y	SLC35F5_uc002tkt.2_RNA|SLC35F5_uc002tkv.2_Missense_Mutation_p.D178Y|SLC35F5_uc002tkw.2_Missense_Mutation_p.D184Y	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	184					transport	integral to membrane					0						TTTTCAGTATCAATGTTTGTG	0.358													70	218					1.37693e-34	1.70775e-34	1	0	A	114501302	A	A	114501302	3	1	10	1	0	0	0	0	1	0	0	0	14656	826	29	2	1061	2	SLC35F5	2	114501302	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	1863053	114501302	128698071	29	2573											
PTPN4	5775	broad.mit.edu	37	chr2	120718402	120718402	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatggaaattccttcttccaGcattataaatcagtacattg	13	14	6	8	0	2	0	1	0	1	0	4	2	4	1	2	1	2	2	2	1	5	7			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:120718402G>T	uc002tmf.1	+	23	2924	c.2153G>T	c.(2152-2154)AGC>ATC	p.S718I	PTPN4_uc010flj.1_Missense_Mutation_p.S431I|PTPN4_uc010yyr.1_Missense_Mutation_p.S351I	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	718	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	CCTTCTTCCAGCATTATAAAT	0.358													67	155					1.20466e-24	1.40299e-24	1	0	T	120718402	T	T	120718402	3	4	10	1	0	0	0	0	1	0	0	0	12855	971	34	4	2239	4	PTPN4	2	120718402	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	6217100	120718402	122480971	30	2574											
POTEE	445582	broad.mit.edu	37	chr2	132020968	132020968	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaaagacgtcttgcatgAaaatagtacgttgcgggaag	16	8	12	5	3	1	3	0	1	1	2	1	4	1	4	0	1	3	3	0	1	7	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:132020968A>G	uc002tsn.2	+	15	1992	c.1940A>G	c.(1939-1941)GAA>GGA	p.E647G	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Missense_Mutation_p.E247G|POTEE_uc002tsl.2_Missense_Mutation_p.E229G|POTEE_uc010fmy.1_Missense_Mutation_p.E111G	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	647	Potential.						ATP binding				0						GTCTTGCATGAAAATAGTACG	0.348													26	52					0	0	0	0	G	132020968	G	G	132020968	3	3	10	1	0	0	0	0	1	0	0	0	12319	246	9	5	1998	5	POTEE	2	132020968	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	11302566	132020968	111178405	31	2575											
ARL6IP6	151188	broad.mit.edu	37	chr2	153591558	153591558	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctggattctcctgttgcAgcttttcttggacagtgact	5	16	10	10	0	2	1	0	1	2	0	3	3	2	3	1	2	3	4	1	2	0	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:153591558A>T	uc002tyn.2	+	3	1221	c.505A>T	c.(505-507)AGC>TGC	p.S169C	ARL6IP6_uc002tym.2_RNA|ARL6IP6_uc002tyo.2_Missense_Mutation_p.S61C	NM_152522	NP_689735	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting	169	Helical; (Potential).					integral to membrane					0						CTCCTGTTGCAGCTTTTCTTG	0.393													109	225					0	0	0	0	T	153591558	T	T	153591558	3	4	10	1	0	0	0	0	1	0	0	0	947	188	7	5	515	5	ARL6IP6	2	153591558	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	21570590	153591558	89607815	32	2576											
TTN	7273	broad.mit.edu	37	chr2	179432093	179432093	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccaccatcaattctaattgCatcttttacaataagtaaag	15	13	3	10	0	3	0	1	0	2	0	3	0	3	0	2	0	2	2	2	0	7	7			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr2:179432093C>T	uc010zfg.1	-	275	71286	c.71062G>A	c.(71062-71064)GCA>ACA	p.A23688T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A17383T|TTN_uc010zfi.1_Missense_Mutation_p.A17316T|TTN_uc010zfj.1_Missense_Mutation_p.A17191T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24615							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTCTAATTGCATCTTTTACA	0.353													11	415					0	0	0	0	T	179432093	T	T	179432093	3	4	10	1	0	0	0	0	1	0	0	0	16803	710	25	4	29361	4	TTN	2	179432093	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	25840535	179432093	63767280	33	2577											
FOXP1	27086	broad.mit.edu	37	chr3	71247445	71247445	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcccctcccgaagaccgcCgcactctagtaagtggttgc	7	7	10	17	4	1	1	0	0	1	1	2	2	2	1	6	1	1	3	6	1	3	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr3:71247445C>A	uc003dol.2	-	2	411	c.88G>T	c.(88-90)GGC>TGC	p.G30C	FOXP1_uc003dom.2_Missense_Mutation_p.G30C|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Missense_Mutation_p.G30C|FOXP1_uc003dop.2_Missense_Mutation_p.G30C|FOXP1_uc003doq.1_Missense_Mutation_p.G30C|FOXP1_uc003dos.2_Missense_Mutation_p.G30C	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	30					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		CGAAGACCGCCGCACTCTAGT	0.602			T	PAX5	ALL								69	98					2.69673e-31	3.30177e-31	1	0	A	71247445	A	A	71247445	3	1	10	1	0	0	0	0	1	0	0	0	6060	652	23	3	2178	3	FOXP1	3	71247445	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08		71247445	126774985	34	2578											
CLCN2	1181	broad.mit.edu	37	chr3	184069802	184069802	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccaggctgctggccctaccTtgtgcaaagaggtccgctcc	6	8	12	15	1	0	1	0	0	0	1	2	1	2	1	5	3	3	4	5	3	2	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr3:184069802T>G	uc003foi.2	-	22	2538	c.2414A>C	c.(2413-2415)AAG>ACG	p.K805T	CLCN2_uc003foh.2_Intron|CLCN2_uc010hya.1_Missense_Mutation_p.K788T|CLCN2_uc011brl.1_Missense_Mutation_p.K805T|CLCN2_uc011brm.1_Missense_Mutation_p.K761T	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	805	CBS 2.|Cytoplasmic (By similarity).					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	TGGCCCTACCTTGTGCAAAGA	0.577													483	156					0	0	0	0	G	184069802	G	G	184069802	3	3	10	1	0	0	0	0	1	0	0	0	3478	1623	56	5	294	5	CLCN2	3	184069802	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	112822357	184069802	13952628	35	2579											
TFRC	7037	broad.mit.edu	37	chr3	195780420	195780420	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atacagccactgtaaactcaGgcccatttcctgaaacagac	14	8	6	13	0	1	2	1	1	0	1	2	2	2	2	3	1	4	1	3	1	4	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr3:195780420G>T	uc003fvz.3	-	18	2192	c.1909C>A	c.(1909-1911)CTG>ATG	p.L637M	TFRC_uc003fwa.3_Missense_Mutation_p.L637M|TFRC_uc010hzy.2_Missense_Mutation_p.L556M|TFRC_uc011btr.1_Missense_Mutation_p.L355M	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	637	Extracellular (Potential).|Ligand-binding.				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		TGTAAACTCAGGCCCATTTCC	0.393			T	BCL6	NHL								101	80					1.19336e-48	1.51954e-48	1	0	T	195780420	T	T	195780420	3	4	10	1	0	0	0	0	1	0	0	0	15878	991	35	4	381	4	TFRC	3	195780420	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	11710618	195780420	2242010	36	2580											
GBA3	57733	broad.mit.edu	37	chr4	22749649	22749649	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaattttttccagatccatcTtggaaaaatgtggattggat	12	15	9	5	0	1	1	0	0	1	1	3	5	3	4	2	3	0	0	2	3	3	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr4:22749649T>A	uc003gqp.3	+	3	1108	c.1017T>A	c.(1015-1017)TCT>TCA	p.S339S	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Silent_p.S340S	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	339					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						CAGATCCATCTTGGAAAAATG	0.368													13	15					0	0	0	0	A	22749649	A	A	22749649	2	1	10	1	0	0	0	0	0	0	0	1	6303	1596	56	5		5	GBA3	4	22749649	Silent	SNP	T	TCGA-BA-5555-01A-01D-1512-08		22749649	168404627	37	2581											
SLC4A4	8671	broad.mit.edu	37	chr4	72429555	72429555	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttccaagtattaaaattccaAtggacatcatggaacagcaa	17	10	6	8	0	1	0	1	0	0	0	3	2	3	2	2	2	2	2	2	2	7	4	rs150809470		TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr4:72429555A>G	uc003hfy.2	+	24	3262	c.3145A>G	c.(3145-3147)ATG>GTG	p.M1049V	SLC4A4_uc010iic.2_Intron|SLC4A4_uc010iib.2_Missense_Mutation_p.M965V|SLC4A4_uc003hfz.2_Missense_Mutation_p.M1049V|SLC4A4_uc003hgc.3_Missense_Mutation_p.M1005V|SLC4A4_uc010iid.2_Missense_Mutation_p.M253V	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	1049	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TAAAATTCCAATGGACATCAT	0.373													86	138					0	0	0	0	G	72429555	G	G	72429555	3	3	10	1	0	0	0	0	1	0	0	0	14720	101	4	5	3356	5	SLC4A4	4	72429555	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	49679906	72429555	118724721	38	2582											
ENPEP	2028	broad.mit.edu	37	chr4	111474548	111474548	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattcgatatatctcatataAcagctatgggaagaacatgg	15	11	8	7	1	1	1	1	0	1	1	3	3	1	2	0	2	3	1	0	2	7	6			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr4:111474548A>G	uc003iab.3	+	18	2921	c.2579A>G	c.(2578-2580)AAC>AGC	p.N860S		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	860	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ATCTCATATAACAGCTATGGG	0.393													121	129					0	0	0	0	G	111474548	G	G	111474548	3	3	10	1	0	0	0	0	1	0	0	0	5152	43	2	5	2649	5	ENPEP	4	111474548	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	39044993	111474548	79679728	39	2583											
FNIP2	57600	broad.mit.edu	37	chr4	159782919	159782919	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atccgtataatcctctttggGcacagctgggttagtaccta	9	13	9	10	1	1	0	0	0	1	0	3	0	3	0	3	2	2	5	3	2	5	6			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr4:159782919G>A	uc003iqe.3	+	12	1639	c.1456G>A	c.(1456-1458)GCA>ACA	p.A486T		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	486					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		TCCTCTTTGGGCACAGCTGGG	0.443													108	114					0	0	0	0	A	159782919	A	A	159782919	3	1	10	1	0	0	0	0	1	0	0	0	6008	1203	42	4	1502	4	FNIP2	4	159782919	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	48308371	159782919	31371357	40	2584											
SPATA4	132851	broad.mit.edu	37	chr4	177113893	177113893	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtaattctgataacctaatGttatctttaatagacttcga	14	16	5	6	1	2	2	0	1	2	1	3	3	2	2	1	0	1	2	1	0	6	9			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr4:177113893G>A	uc003iuo.1	-	4	682	c.573C>T	c.(571-573)AAC>AAT	p.N191N		NM_144644	NP_653245	Q8NEY3	SPAT4_HUMAN	spermatogenesis associated 4	191					apoptosis|spermatogenesis						0		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)		ATAACCTAATGTTATCTTTAA	0.383													49	57					0	0	0	0	A	177113893	A	A	177113893	2	1	10	1	0	0	0	0	0	0	0	1	15076	1368	48	4		4	SPATA4	4	177113893	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	17330974	177113893	14040383	41	2585											
AHRR	57491	broad.mit.edu	37	chr5	423993	423993	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggaggctgctcagggcccaGgagtggggcacaggcacgcc	7	3	19	12	1	1	0	1	0	0	0	1	2	1	2	2	7	1	4	2	7	0	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr5:423993G>A	uc003jav.2	+	7	665	c.621G>A	c.(619-621)CAG>CAA	p.Q207Q	AHRR_uc003jaw.2_Silent_p.Q203Q|AHRR_uc010isy.2_Silent_p.Q53Q|AHRR_uc010isz.2_Silent_p.Q203Q|AHRR_uc003jax.2_5'UTR|AHRR_uc003jay.2_Silent_p.Q63Q	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			TCAGGGCCCAGGAGTGGGGCA	0.657													54	59					0	0	0	0	A	423993	A	A	423993	2	1	10	1	0	0	0	0	0	0	0	1	417	991	35	4		4	AHRR	5	423993	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08		423993	180491267	42	2586											
ADAMTS16	170690	broad.mit.edu	37	chr5	5182363	5182363	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catcaacccctgcacagcagCgaccttcgcctgggactgcc	8	6	9	18	2	1	0	1	0	0	0	2	2	1	1	5	1	5	2	5	1	1	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr5:5182363C>G	uc003jdl.2	+	4	846	c.708C>G	c.(706-708)AGC>AGG	p.S236R	ADAMTS16_uc003jdk.1_Missense_Mutation_p.S236R|ADAMTS16_uc003jdj.1_Missense_Mutation_p.S236R	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	236					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TGCACAGCAGCGACCTTCGCC	0.522													46	82					0	0	0	0	G	5182363	G	G	5182363	3	3	10	1	0	0	0	0	1	0	0	0	261	767	27	3	722	3	ADAMTS16	5	5182363	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	4758370	5182363	175732897	43	2587											
PRDM9	56979	broad.mit.edu	37	chr5	23527862	23527862	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacaggggagaagccctacGtctgcagggaggatgagtaa	13	5	15	8	1	1	2	0	1	1	1	1	5	1	4	1	4	3	2	1	4	3	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr5:23527862G>T	uc003jgo.2	+	11	2847	c.2665G>T	c.(2665-2667)GTC>TTC	p.V889F		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	889					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GAAGCCCTACGTCTGCAGGGA	0.522										HNSCC(3;0.000094)			17	112					6.49762e-13	7.05139e-13	1	0	T	23527862	T	T	23527862	3	4	10	1	0	0	0	0	1	0	0	0	12525	1145	40	3	2703	3	PRDM9	5	23527862	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	18345499	23527862	157387398	44	2588											
C7	730	broad.mit.edu	37	chr5	40981608	40981608	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgagtgtgaggcgggcgCtctgagatgcagagggcaga	8	7	19	7	2	2	5	0	3	2	3	2	6	2	5	0	3	1	3	0	3	0	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr5:40981608C>T	uc003jmh.2	+	18	2579	c.2465C>T	c.(2464-2466)GCT>GTT	p.A822V		NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	822	Complement control factor I module 2.			GA -> AL (in Ref. 3).	complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				GAGGCGGGCGCTCTGAGATGC	0.567													22	36					0	0	0	0	T	40981608	T	T	40981608	3	4	10	1	0	0	0	0	1	0	0	0	2386	797	28	4	2535	4	C7	5	40981608	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	17453746	40981608	139933652	45	2589											
HCN1	348980	broad.mit.edu	37	chr5	45262156	45262156	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttcggggggatggctcccGacgacatctgtcggaagagg	7	7	18	9	4	1	1	0	0	1	1	4	5	2	3	1	7	0	2	1	7	1	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr5:45262156G>T	uc003jok.2	-	8	2565	c.2540C>A	c.(2539-2541)TCG>TAG	p.S847*		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	847	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GATGGCTCCCGACGACATCTG	0.642													46	180					9.58827e-17	1.08365e-16	1	0	T	45262156	T	T	45262156	4	4	10	1	0	0	0	0	0	1	0	0	7035	1059	37	3	136	3	HCN1	5	45262156	Nonsense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	4280548	45262156	135653104	46	2590											
MAP1B	4131	broad.mit.edu	37	chr5	71494697	71494697	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccgtgcctcagtgttattcGatacaatgcaacaccatcta	11	12	6	12	2	2	0	1	0	1	0	4	1	3	0	3	0	4	2	3	0	5	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr5:71494697G>A	uc003kbw.3	+	5	5756	c.5515G>A	c.(5515-5517)GAT>AAT	p.D1839N	MAP1B_uc010iyw.1_Missense_Mutation_p.D1856N|MAP1B_uc010iyx.1_Missense_Mutation_p.D1713N|MAP1B_uc010iyy.1_Missense_Mutation_p.D1713N	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1839						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AGTGTTATTCGATACAATGCA	0.493													40	44					0	0	0	0	A	71494697	A	A	71494697	3	1	10	1	0	0	0	0	1	0	0	0	9281	1058	37	1	5533	1	MAP1B	5	71494697	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	26232541	71494697	109420563	47	2591											
FBN2	2201	broad.mit.edu	37	chr5	127646995	127646995	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcaaattcatctcaccttCacagatgcgggtatcctcgc	10	11	6	14	2	4	1	4	0	1	1	7	1	5	1	2	1	1	1	2	1	2	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr5:127646995C>G	uc003kuu.2	-	39	5510	c.5071G>C	c.(5071-5073)GAA>CAA	p.E1691Q		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1691	EGF-like 27; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ATCTCACCTTCACAGATGCGG	0.498													21	25					0	0	0	0	G	127646995	G	G	127646995	3	3	10	1	0	0	0	0	1	0	0	0	5735	835	29	2	3775	2	FBN2	5	127646995	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	56152298	127646995	53268265	48	2592											
FAM13B	51306	broad.mit.edu	37	chr5	137346746	137346746	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgaaaaatcttcctcttcaTtctcaaaaaactcatagtag	16	13	3	9	0	5	1	3	1	3	0	7	1	6	1	1	0	1	1	1	0	7	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr5:137346746T>A	uc003lbz.2	-	6	1175	c.641A>T	c.(640-642)AAT>ATT	p.N214I	FAM13B_uc003lcb.2_Missense_Mutation_p.N96I|FAM13B_uc003lca.2_Missense_Mutation_p.N214I	NM_016603	NP_057687	Q9NYF5	FA13B_HUMAN	hypothetical protein LOC51306 isoform 1	214	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						TTCCTCTTCATTCTCAAAAAA	0.303													70	60					0	0	0	0	A	137346746	A	A	137346746	3	1	10	1	0	0	0	0	1	0	0	0	5481	1493	52	5	2248	5	FAM13B	5	137346746	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	9699751	137346746	43568514	49	2593											
NSD1	64324	broad.mit.edu	37	chr5	176637762	176637762	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcaaacagcccaagttcCgaagtataaagtgcaaacac	19	5	7	10	1	0	0	0	0	0	0	1	1	1	0	2	0	5	4	2	0	8	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr5:176637762C>T	uc003mfr.3	+	5	2500	c.2362C>T	c.(2362-2364)CGA>TGA	p.R788*	NSD1_uc003mft.3_Nonsense_Mutation_p.R519*|NSD1_uc003mfs.1_Nonsense_Mutation_p.R685*|NSD1_uc011dfx.1_Nonsense_Mutation_p.R436*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	788					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GCCCAAGTTCCGAAGTATAAA	0.413			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			38	45					0	0	0	0	T	176637762	T	T	176637762	4	4	10	1	0	0	0	0	0	1	0	0	10723	644	23	1	2376	1	NSD1	5	176637762	Nonsense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	39291016	176637762	4277498	50	2594											
PGBD1	84547	broad.mit.edu	37	chr6	28269689	28269689	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaacaatgagataattttGtgtcgttggtatggggatgg	12	13	14	2	1	0	1	0	1	0	1	1	4	0	2	0	4	1	2	0	4	5	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:28269689G>C	uc003nky.2	+	7	2428	c.2058G>C	c.(2056-2058)TTG>TTC	p.L686F	PGBD1_uc003nkz.2_Missense_Mutation_p.L686F	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	686					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						AGATAATTTTGTGTCGTTGGT	0.388													84	311					0	0	0	0	C	28269689	C	C	28269689	3	2	10	1	0	0	0	0	1	0	0	0	11835	1368	48	4	2080	4	PGBD1	6	28269689	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08		28269689	142845378	51	2595											
NOTCH4	4855	broad.mit.edu	37	chr6	32168683	32168683	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctcccactgcagccatcgCagcaaggaagcggagtagaa	12	4	13	12	2	0	1	0	0	0	1	2	3	1	3	2	3	4	5	2	3	4	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:32168683C>T	uc003obb.2	-	23	4379	c.4240G>A	c.(4240-4242)GCG>ACG	p.A1414T	NOTCH4_uc003oba.2_Missense_Mutation_p.A77T|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1414	Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GCAGCCATCGCAGCAAGGAAG	0.647													30	33					0	0	0	0	T	32168683	T	T	32168683	3	4	10	1	0	0	0	0	1	0	0	0	10605	710	25	4	1803	4	NOTCH4	6	32168683	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	3898994	32168683	138946384	52	2596											
NOTCH4	4855	broad.mit.edu	37	chr6	32188357	32188357	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagttctggcaggtgcccccGtttctgcagtgagggggacc	5	9	16	11	1	2	1	0	1	2	0	2	3	2	2	3	4	2	4	3	4	0	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:32188357G>A	uc003obb.2	-	6	1123	c.984C>T	c.(982-984)AAC>AAT	p.N328N	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Silent_p.N328N	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	328	EGF-like 8; calcium-binding (Potential).|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						AGGTGCCCCCGTTTCTGCAGT	0.617													44	141					0	0	0	0	A	32188357	A	A	32188357	2	1	10	1	0	0	0	0	0	0	0	1	10605	1136	40	1		1	NOTCH4	6	32188357	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	19674	32188357	138926710	53	2597											
HLA-DQA2	3118	broad.mit.edu	37	chr6	32713831	32713831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcactggggcctggacgagCctcttctgaaacactggggt	8	8	14	11	1	2	1	0	1	2	0	2	3	2	2	2	5	3	1	2	5	1	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:32713831C>T	uc003obx.2	+	3	653	c.595C>T	c.(595-597)CCT>TCT	p.P199S		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	199	Alpha-2.|Extracellular (Potential).|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTGGACGAGCCTCTTCTGAA	0.488													97	255					0	0	0	0	T	32713831	T	T	32713831	3	4	10	1	0	0	0	0	1	0	0	0	7244	739	26	4	605	4	HLA-DQA2	6	32713831	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	525474	32713831	138401236	54	2598											
UHRF1BP1	54887	broad.mit.edu	37	chr6	34827076	34827076	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctacaggccaagaaactgagCagaacccaagcctccagctc	14	4	8	15	0	0	3	0	1	0	2	2	3	1	3	4	1	6	2	4	1	5	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:34827076C>T	uc003oju.3	+	14	3177	c.2943C>T	c.(2941-2943)AGC>AGT	p.S981S	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	981										ovary(3)	3						AGAAACTGAGCAGAACCCAAG	0.572													65	86					0	0	0	0	T	34827076	T	T	34827076	2	4	10	1	0	0	0	0	0	0	0	1	17036	709	25	4		4	UHRF1BP1	6	34827076	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	2113245	34827076	136287991	55	2599											
DNAH8	1769	broad.mit.edu	37	chr6	38754589	38754589	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagaaacagggaagttgcTggttaatttcgatcccaaaa	14	10	9	8	1	0	1	0	0	0	1	3	3	2	2	2	2	2	3	2	2	5	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:38754589T>C	uc003ooe.1	+	16	2393	c.1793T>C	c.(1792-1794)CTG>CCG	p.L598P		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GGGAAGTTGCTGGTTAATTTC	0.363													77	99					0	0	0	0	C	38754589	C	C	38754589	3	2	10	1	0	0	0	0	1	0	0	0	4629	1580	55	5	1847	5	DNAH8	6	38754589	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	3927513	38754589	132360478	56	2600											
CUL9	23113	broad.mit.edu	37	chr6	43153942	43153943	+	Frame_Shift_Ins	INS	-	C	C																															catgtcacctccccggccaaINScccggtccatctttcagccc																										TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:43153942_43153943insC	uc003ouk.2	+	4	1075_1076	c.1000_1001insC	c.(1000-1002)ACCfs	p.T334fs	CUL9_uc003ouj.1_Frame_Shift_Ins_p.T334fs|CUL9_uc003oul.2_Frame_Shift_Ins_p.T334fs|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	334					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						TCCCCGGCCAACCCGGTCCATC	0.614													---	---	---								C	43153943	C	C	43153942	7	5	10	1	0	1	1	0	0	0	0	0	4078	43	2	0	1010	0	CUL9	6	43153942	Frame_Shift_Ins	INS	-	TCGA-BA-5555-01A-01D-1512-08	4399353	43153942	127961125	57	2601											
GPR111	222611	broad.mit.edu	37	chr6	47649207	47649207	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctggagataacattggaaaAaatttcactttttctatgag	14	15	7	5	0	3	2	1	1	2	1	3	4	3	3	0	2	1	0	0	2	5	6			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:47649207A>C	uc010jzj.1	+	6	913	c.912A>C	c.(910-912)AAA>AAC	p.K304N	GPR111_uc010jzk.1_Missense_Mutation_p.K236N|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	304	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						ACATTGGAAAAAATTTCACTT	0.398													89	293					0	0	0	0	C	47649207	C	C	47649207	3	2	10	1	0	0	0	0	1	0	0	0	6666	11	1	5	726	5	GPR111	6	47649207	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	4495265	47649207	123465860	58	2602											
DEFB112	245915	broad.mit.edu	37	chr6	50016327	50016327	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtctttgagtacatttttTcaagtttcagtctacatatg	9	20	6	6	0	4	1	2	1	2	0	4	1	4	1	0	0	2	2	0	0	4	9			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:50016327T>C	uc011dws.1	-	1	38	c.38A>G	c.(37-39)GAA>GGA	p.E13G		NM_001037498	NP_001032587	Q30KQ8	DB112_HUMAN	beta-defensin 112 precursor	13					defense response to bacterium	extracellular region				central_nervous_system(1)	1	Lung NSC(77;0.042)					GTACATTTTTTCAAGTTTCAG	0.328													120	121					0	0	0	0	C	50016327	C	C	50016327	3	2	10	1	0	0	0	0	1	0	0	0	4422	1783	62	5	310	5	DEFB112	6	50016327	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	2367120	50016327	121098740	59	2603											
ZNF451	26036	broad.mit.edu	37	chr6	57012576	57012576	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatttttatgagatggatGaggtagaaggtgaaactttg	13	14	13	1	0	0	4	0	3	0	2	0	7	0	5	0	3	1	1	0	3	5	6			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:57012576G>T	uc003pdm.1	+	10	1917	c.1693G>T	c.(1693-1695)GAG>TAG	p.E565*	ZNF451_uc003pdl.2_Nonsense_Mutation_p.E565*|ZNF451_uc003pdn.1_Nonsense_Mutation_p.E565*|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Nonsense_Mutation_p.E565*	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TGAGATGGATGAGGTAGAAGG	0.393													119	313					4.07119e-57	5.32601e-57	1	0	T	57012576	T	T	57012576	4	4	10	1	0	0	0	0	0	1	0	0	17989	1291	45	2	1731	2	ZNF451	6	57012576	Nonsense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	6996249	57012576	114102491	60	2604											
MCHR2	84539	broad.mit.edu	37	chr6	100390920	100390920	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagacccagacaggcaatgcCaggataaaggaagctgccca	15	4	11	11	0	0	2	0	0	0	2	0	4	0	4	3	3	3	2	3	3	5	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr6:100390920C>A	uc003pqh.1	-	4	807	c.492G>T	c.(490-492)CTG>CTT	p.L164L	MCHR2_uc003pqi.1_Silent_p.L164L	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	164	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		CAGGCAATGCCAGGATAAAGG	0.478													72	104					1.93348e-29	2.3373e-29	1	0	A	100390920	A	A	100390920	2	1	10	1	0	0	0	0	0	0	0	1	9436	581	21	4		4	MCHR2	6	100390920	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	43378344	100390920	70724147	61	2605											
SDK1	221935	broad.mit.edu	37	chr7	4002400	4002400	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcgcatccagaagctgcGtccagaggactccggaatct	9	7	11	14	3	1	2	0	0	1	2	4	4	4	4	4	2	3	2	4	2	2	0	rs148101694		TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr7:4002400G>A	uc003smx.2	+	9	1485	c.1346G>A	c.(1345-1347)CGT>CAT	p.R449H		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	449	Ig-like C2-type 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CAGAAGCTGCGTCCAGAGGAC	0.587													21	33					0	0	0	0	A	4002400	A	A	4002400	3	1	10	1	0	0	0	0	1	0	0	0	14033	1145	40	1	1380	1	SDK1	7	4002400	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08		4002400	155136263	62	2606											
PDE1C	5137	broad.mit.edu	37	chr7	32338306	32338306	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atgctgaaagtggcgctccgGcattttttgaagccctcctt	7	13	10	11	2	0	2	0	2	0	0	2	2	2	2	3	2	2	3	3	2	2	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr7:32338306G>T	uc003tco.1	-	1	636	c.42C>A	c.(40-42)TGC>TGA	p.C14*		NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	Error:Variant_position_missing_in_Q14123_after_alignment					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TGGCGCTCCGGCATTTTTTGA	0.662													7	16					0.00307968	0.00317956	1	0	T	32338306	T	T	32338306	4	4	10	1	0	0	0	0	0	1	0	0	11689	1218	42	4		4	PDE1C	7	32338306	Nonsense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	28335906	32338306	126800357	63	2607											
PCLO	27445	broad.mit.edu	37	chr7	82580369	82580369	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttaaagtgggaacagagtCtatcgtctcagcagtaagag	13	9	13	6	1	2	2	1	0	2	2	4	3	2	3	0	2	2	3	0	2	5	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr7:82580369C>G	uc003uhx.2	-	6	9824	c.9535G>C	c.(9535-9537)GAC>CAC	p.D3179H	PCLO_uc003uhv.2_Missense_Mutation_p.D3179H|PCLO_uc010lec.2_Missense_Mutation_p.D144H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3110					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGAACAGAGTCTATCGTCTCA	0.423													11	53					0	0	0	0	G	82580369	G	G	82580369	3	3	10	1	0	0	0	0	1	0	0	0	11637	913	32	2	5990	2	PCLO	7	82580369	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	50242063	82580369	76558294	64	2608											
AKAP9	10142	broad.mit.edu	37	chr7	91729178	91729178	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacagacaggagctggtagaGataatgtatgtccattttta	13	12	11	5	0	0	2	0	0	0	2	1	5	1	3	1	2	1	3	1	2	4	6			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr7:91729178G>C	uc003ulg.2	+	44	11116	c.10891G>C	c.(10891-10893)GAT>CAT	p.D3631H	AKAP9_uc003ulf.2_Missense_Mutation_p.D3623H|AKAP9_uc003uli.2_Missense_Mutation_p.D3254H|AKAP9_uc003ulj.2_Missense_Mutation_p.D1401H|AKAP9_uc003ull.2_Missense_Mutation_p.D527H	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3635	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGCTGGTAGAGATAATGTATG	0.378			T	BRAF	papillary thyroid								26	165					0	0	0	0	C	91729178	C	C	91729178	3	2	10	1	0	0	0	0	1	0	0	0	459	942	33	2	11065	2	AKAP9	7	91729178	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	9148809	91729178	67409485	65	2609											
PPP1R9A	55607	broad.mit.edu	37	chr7	94879416	94879416	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaaacatagaagagaataagGaaagaatgttgaagttggaa	22	7	11	1	0	0	4	0	1	0	3	0	7	0	6	0	2	1	2	0	2	10	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr7:94879416G>T	uc003unp.2	+	9	2461	c.2179G>T	c.(2179-2181)GAA>TAA	p.E727*	PPP1R9A_uc010lfj.2_Nonsense_Mutation_p.E749*|PPP1R9A_uc011kif.1_Nonsense_Mutation_p.E727*|PPP1R9A_uc003unq.2_Nonsense_Mutation_p.E727*|PPP1R9A_uc011kig.1_Nonsense_Mutation_p.E727*	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	727	Interacts with TGN38 (By similarity).|Potential.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGAGAATAAGGAAAGAATGTT	0.433										HNSCC(28;0.073)			19	41					8.28177e-16	9.2504e-16	1	0	T	94879416	T	T	94879416	4	4	10	1	0	0	0	0	0	1	0	0	12438	1175	41	2	2279	2	PPP1R9A	7	94879416	Nonsense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	3150238	94879416	64259247	66	2610											
TSGA14	95681	broad.mit.edu	37	chr7	130038842	130038842	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcgggcaccaggcacctTggactctcttccggaggagt	6	9	13	13	2	1	0	0	0	1	0	4	3	2	3	3	5	0	3	3	5	0	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr7:130038842T>A	uc003vpz.2	-	11	1059	c.1012A>T	c.(1012-1014)AAG>TAG	p.K338*	TSGA14_uc003vpy.2_Nonsense_Mutation_p.K100*|TSGA14_uc010lmf.2_Nonsense_Mutation_p.K135*|TSGA14_uc003vqa.2_Nonsense_Mutation_p.K266*|TSGA14_uc011kpg.1_Nonsense_Mutation_p.K250*	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	338					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					CCAGGCACCTTGGACTCTCTT	0.592													110	184					0	0	0	0	A	130038842	A	A	130038842	4	1	10	1	0	0	0	0	0	1	0	0	16687	1821	63	5	113	5	TSGA14	7	130038842	Nonsense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	35159426	130038842	29099821	67	2611											
AKR1B10	57016	broad.mit.edu	37	chr7	134215455	134215455	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgcaggatatcggcacAttgactgtgcctatgtctat	9	14	10	8	1	1	2	0	2	1	0	2	3	1	3	1	2	2	2	1	2	3	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr7:134215455A>C	uc003vrr.2	+	2	447	c.127A>C	c.(127-129)ATT>CTT	p.I43L		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	43					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						ATATCGGCACATTGACTGTGC	0.458													27	133					0	0	0	0	C	134215455	C	C	134215455	3	2	10	1	0	0	0	0	1	0	0	0	467	217	8	5	133	5	AKR1B10	7	134215455	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	4176613	134215455	24923208	68	2612											
TRPV6	55503	broad.mit.edu	37	chr7	142571344	142571344	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacatgaagggcaggtccaCgttgtagttggctgggccat	8	10	15	8	1	0	1	0	1	0	0	1	1	1	1	2	4	1	6	2	4	3	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr7:142571344C>A	uc003wbx.1	-	13	1861	c.1645G>T	c.(1645-1647)GTG>TTG	p.V549L	TRPV6_uc003wbw.1_Missense_Mutation_p.V335L|TRPV6_uc010lou.1_Missense_Mutation_p.V420L	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	549					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GGCAGGTCCACGTTGTAGTTG	0.562													78	165					2.51111e-31	3.09433e-31	1	0	A	142571344	A	A	142571344	3	1	10	1	0	0	0	0	1	0	0	0	16667	536	19	3	544	3	TRPV6	7	142571344	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	8355889	142571344	16567319	69	2613											
GIMAP4	55303	broad.mit.edu	37	chr7	150269705	150269705	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagacttgatggacattttcGgtgaccgctactgtgcgtta	9	13	11	8	3	0	3	0	2	0	1	1	4	0	4	1	2	2	2	1	2	3	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr7:150269705G>T	uc003whl.2	+	3	629	c.547G>T	c.(547-549)GGT>TGT	p.G183C	GIMAP4_uc011kuu.1_Missense_Mutation_p.G44C|GIMAP4_uc011kuv.1_Missense_Mutation_p.G197C	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	183							GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGACATTTTCGGTGACCGCTA	0.512													21	151					1.28384e-07	1.34733e-07	1	0	T	150269705	T	T	150269705	3	4	10	1	0	0	0	0	1	0	0	0	6418	1116	39	3	553	3	GIMAP4	7	150269705	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	7698361	150269705	8868958	70	2614											
EYA1	2138	broad.mit.edu	37	chr8	72229916	72229916	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagtcttgatgcctgcccAcaatgcacctaaatcagtta	11	12	6	12	0	3	1	2	1	1	0	3	1	3	1	3	0	3	2	3	0	4	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr8:72229916A>G	uc003xys.3	-	6	714	c.427T>C	c.(427-429)TGG>CGG	p.W143R	EYA1_uc003xyr.3_Intron|EYA1_uc003xyt.3_Missense_Mutation_p.W110R|EYA1_uc010lzf.2_Missense_Mutation_p.W70R|EYA1_uc003xyu.2_Missense_Mutation_p.W143R|EYA1_uc011lfe.1_Intron|EYA1_uc003xyv.2_Intron	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	143					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			ATGCCTGCCCACAATGCACCT	0.428													108	241					0	0	0	0	G	72229916	G	G	72229916	3	3	10	1	0	0	0	0	1	0	0	0	5353	159	6	5	1399	5	EYA1	8	72229916	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08		72229916	74134106	71	2615											
KCNB2	9312	broad.mit.edu	37	chr8	73480044	73480044	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcccttcctccagagcctgtGgacattatccggagcaaaac	10	9	8	14	1	0	1	0	0	0	1	4	3	4	3	5	2	3	1	5	2	3	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr8:73480044G>T	uc003xzb.2	+	2	663	c.75G>T	c.(73-75)GTG>GTT	p.V25V		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	25	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CAGAGCCTGTGGACATTATCC	0.547													86	173					1.07134e-49	1.3826e-49	1	0	T	73480044	T	T	73480044	2	4	10	1	0	0	0	0	0	0	0	1	8052	1335	47	4		4	KCNB2	8	73480044	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	1250128	73480044	72883978	72	2616											
VPS13B	157680	broad.mit.edu	37	chr8	100829989	100829989	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagactggtcaagagatgtGtgcctggaatccaaagcccc	12	7	12	10	0	1	2	1	0	0	2	2	5	2	3	4	2	2	0	4	2	4	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr8:100829989G>T	uc003yiv.2	+	45	8505	c.8394G>T	c.(8392-8394)GTG>GTT	p.V2798V	VPS13B_uc003yiw.2_Silent_p.V2773V	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2798					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAAGAGATGTGTGCCTGGAAT	0.418													100	69					9.45097e-43	1.19545e-42	1	0	T	100829989	T	T	100829989	2	4	10	1	0	0	0	0	0	0	0	1	17258	1364	48	4		4	VPS13B	8	100829989	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	27349945	100829989	45534033	73	2617											
FER1L6	654463	broad.mit.edu	37	chr8	125076699	125076699	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccacctcccacagtggtgcCcgactctgcccaggcccagc	6	5	10	20	1	1	0	0	0	1	0	2	1	2	0	6	2	3	0	6	2	0	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr8:125076699C>T	uc003yqw.2	+	26	3646	c.3440C>T	c.(3439-3441)CCC>CTC	p.P1147L	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1147	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACAGTGGTGCCCGACTCTGCC	0.607													78	104					0	0	0	0	T	125076699	T	T	125076699	3	4	10	1	0	0	0	0	1	0	0	0	5847	623	22	4	3538	4	FER1L6	8	125076699	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	24246710	125076699	21287323	74	2618											
ASAP1	50807	broad.mit.edu	37	chr8	131249206	131249206	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcttttacagacttcttcActttctgaagggctgttcta	7	18	7	9	0	4	2	1	1	3	1	4	2	4	2	0	1	2	3	0	1	3	8			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr8:131249206A>T	uc003yta.1	-	3	249	c.221T>A	c.(220-222)GTG>GAG	p.V74E	ASAP1_uc011liw.1_Missense_Mutation_p.V67E	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	74					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						AGACTTCTTCACTTTCTGAAG	0.294													37	79					0	0	0	0	T	131249206	T	T	131249206	3	4	10	1	0	0	0	0	1	0	0	0	1012	159	6	5	3276	5	ASAP1	8	131249206	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	6172507	131249206	15114816	75	2619											
TG	7038	broad.mit.edu	37	chr8	134042084	134042084	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agggtccggagaggtgagtgGcaactgggggctgctggacc	7	6	20	8	1	0	2	0	1	0	1	1	4	1	3	2	7	2	3	2	7	1	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr8:134042084G>T	uc003ytw.2	+	41	7096	c.7055G>T	c.(7054-7056)GGC>GTC	p.G2352V	TG_uc010mdw.2_Missense_Mutation_p.G1111V|TG_uc011ljb.1_Missense_Mutation_p.G721V|TG_uc011ljc.1_Missense_Mutation_p.G485V	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2352					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GAGGTGAGTGGCAACTGGGGG	0.572													26	47					2.61193e-14	2.88369e-14	1	0	T	134042084	T	T	134042084	3	4	10	1	0	0	0	0	1	0	0	0	15879	1203	42	4	7217	4	TG	8	134042084	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	2792878	134042084	12321938	76	2620											
SCRIB	23513	broad.mit.edu	37	chr8	144893221	144893221	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgagattgaggtgggtgagCgcgaacggcagactctgcag	9	8	17	7	3	1	4	0	3	1	2	1	6	1	4	0	3	3	2	0	3	1	2	rs146561937	byFrequency	TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr8:144893221C>T	uc003yzp.1	-	11	1135	c.1128G>A	c.(1126-1128)GCG>GCA	p.A376A	SCRIB_uc003yzo.1_Silent_p.A376A	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	376	Sufficient for targeting to adherens junction and to inhibit cell proliferation.|LRR 15.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGTGGGTGAGCGCGAACGGCA	0.687													6	10					0	0	0	0	T	144893221	T	T	144893221	2	4	10	1	0	0	0	0	0	0	0	1	14002	755	27	1		1	SCRIB	8	144893221	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	10851137	144893221	1470801	77	2621											
LINGO2	158038	broad.mit.edu	37	chr9	27950604	27950604	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcagccaatggtggatccCatgaagattaacaccacagc	13	6	11	11	0	0	2	0	1	0	1	1	3	1	3	3	3	3	1	3	3	3	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr9:27950604C>G	uc003zqu.1	-	2	260	c.66G>C	c.(64-66)ATG>ATC	p.M22I	LINGO2_uc010mjf.1_Missense_Mutation_p.M22I|LINGO2_uc003zqv.1_Missense_Mutation_p.M22I	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	22						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TGGTGGATCCCATGAAGATTA	0.542													4	55					0	0	0	0	G	27950604	G	G	27950604	3	3	10	1	0	0	0	0	1	0	0	0	8857	594	21	4	1758	4	LINGO2	9	27950604	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08		27950604	113262827	78	2622											
PAX5	5079	broad.mit.edu	37	chr9	37015148	37015148	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggcgacctttggtttggAtcctccaattaccccaggct	6	13	10	12	1	0	0	0	0	0	0	2	2	2	1	5	4	1	2	5	4	2	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr9:37015148A>G	uc003zzo.1	-	3	704	c.256T>C	c.(256-258)TCC>CCC	p.S86P	PAX5_uc011lpw.1_Missense_Mutation_p.S86P|PAX5_uc011lpx.1_Intron|PAX5_uc011lpy.1_5'UTR|PAX5_uc010mls.1_Missense_Mutation_p.S86P|PAX5_uc011lpz.1_Missense_Mutation_p.S86P|PAX5_uc011lqa.1_5'UTR|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.S86P|PAX5_uc010mlp.1_Missense_Mutation_p.S86P|PAX5_uc011lqc.1_Missense_Mutation_p.S86P|PAX5_uc010mlr.1_Missense_Mutation_p.S86P|PAX5_uc011lqd.1_Intron|PAX5_uc011lqe.1_RNA|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_RNA	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	86	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(32)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		TTTGGTTTGGATCCTCCAATT	0.483			T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								155	203					0	0	0	0	G	37015148	G	G	37015148	3	3	10	1	0	0	0	0	1	0	0	0	11536	333	12	5	951	5	PAX5	9	37015148	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	9064544	37015148	104198283	79	2623											
HSDL2	84263	broad.mit.edu	37	chr9	115216373	115216373	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgtggaagaaacatttagaAttgttaaggactctctcagt	13	13	9	6	0	2	2	1	0	1	2	3	4	2	4	0	2	1	1	0	2	5	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr9:115216373A>G	uc004bga.1	+	9	1039	c.946A>G	c.(946-948)ATT>GTT	p.I316V	HSDL2_uc011lwv.1_Missense_Mutation_p.I195V|HSDL2_uc004bgb.1_Missense_Mutation_p.I150V|HSDL2_uc004bgc.1_Missense_Mutation_p.I243V|HSDL2_uc011lww.1_Missense_Mutation_p.I111V	NM_032303	NP_115679	Q6YN16	HSDL2_HUMAN	hydroxysteroid dehydrogenase like 2	316	SCP2.					peroxisome	oxidoreductase activity|sterol binding				0						AACATTTAGAATTGTTAAGGA	0.398													81	159					0	0	0	0	G	115216373	G	G	115216373	3	3	10	1	0	0	0	0	1	0	0	0	7433	101	4	5	980	5	HSDL2	9	115216373	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	78201225	115216373	25997058	80	2624											
NUP188	23511	broad.mit.edu	37	chr9	131743547	131743547	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttctgttttggcaggtgtAtagcttcttggataagatgt	7	19	11	4	0	2	1	0	0	2	1	2	2	2	2	0	3	1	4	0	3	3	9			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr9:131743547A>G	uc004bws.1	+	15	1416	c.1394A>G	c.(1393-1395)TAT>TGT	p.Y465C		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	465					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TGGCAGGTGTATAGCTTCTTG	0.423													107	335					0	0	0	0	G	131743547	G	G	131743547	3	3	10	1	0	0	0	0	1	0	0	0	10812	449	16	5	1452	5	NUP188	9	131743547	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	16527174	131743547	9469884	81	2625											
ZWINT	11130	broad.mit.edu	37	chr10	58120976	58120976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctctagggctgcagcttccgCctctgtctccgctgcctcca	3	11	9	18	2	3	0	0	0	3	0	6	0	5	0	5	1	3	4	5	1	1	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr10:58120976C>T	uc001jjx.1	-	1	59	c.22G>A	c.(22-24)GCG>ACG	p.A8T	ZWINT_uc001jjy.1_Missense_Mutation_p.A8T|ZWINT_uc001jka.1_Missense_Mutation_p.A8T|ZWINT_uc009xoy.1_RNA	NM_007057	NP_008988	O95229	ZWINT_HUMAN	ZW10 interactor isoform a	8					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding				0						GCAGCTTCCGCCTCTGTCTCC	0.597													10	13					0	0	0	0	T	58120976	T	T	58120976	3	4	10	1	0	0	0	0	1	0	0	0	18316	739	26	4	843	4	ZWINT	10	58120976	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08		58120976	77413771	82	2626											
ENTPD1	953	broad.mit.edu	37	chr10	97583051	97583051	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccatccttggcttctcctCtatcatagctgtgatagctt	7	15	7	12	0	3	1	1	1	2	0	5	1	4	1	3	1	3	3	3	1	3	6			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr10:97583051C>A	uc001klh.3	+	2	398	c.74C>A	c.(73-75)TCT>TAT	p.S25Y	ENTPD1_uc001kle.1_Missense_Mutation_p.S32Y|ENTPD1_uc001kli.3_Missense_Mutation_p.S32Y|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Missense_Mutation_p.S37Y|ENTPD1_uc010qok.1_Intron|ENTPD1_uc010qol.1_Intron|ENTPD1_uc010qom.1_Missense_Mutation_p.S25Y|ENTPD1_uc010qon.1_5'UTR|ENTPD1_uc009xva.2_5'UTR|ENTPD1_uc009xuz.2_RNA	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	25	Helical; (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		GGCTTCTCCTCTATCATAGCT	0.393													66	79					1.17253e-29	1.42645e-29	1	0	A	97583051	A	A	97583051	3	1	10	1	0	0	0	0	1	0	0	0	5162	913	32	2	177	2	ENTPD1	10	97583051	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	39462075	97583051	37951696	83	2627											
OR56A1	120796	broad.mit.edu	37	chr11	6048184	6048184	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaaagaatgaggatgaagtGggagccacatgtgctcaggg	14	6	16	5	0	1	3	1	2	0	1	1	6	1	5	1	3	2	1	1	3	4	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr11:6048184G>T	uc010qzw.1	-	1	751	c.751C>A	c.(751-753)CAC>AAC	p.H251N		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGATGAAGTGGGAGCCACAT	0.493													34	35					3.03874e-20	3.49638e-20	1	0	T	6048184	T	T	6048184	3	4	10	1	0	0	0	0	1	0	0	0	11187	1348	47	4	209	4	OR56A1	11	6048184	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08		6048184	128958332	84	2628											
ABCC8	6833	broad.mit.edu	37	chr11	17434265	17434265	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgggccacactgattcgcTggcgttgaccaccagacagg	8	7	12	14	3	0	3	0	2	0	1	2	3	0	3	3	3	0	2	3	3	0	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr11:17434265T>A	uc001mnc.2	-	21	2630	c.2504A>T	c.(2503-2505)CAG>CTG	p.Q835L		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	835	ABC transporter 1.|Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	ACTGATTCGCTGGCGTTGACC	0.537													6	12					0	0	0	0	A	17434265	A	A	17434265	3	1	10	1	0	0	0	0	1	0	0	0	58	1580	55	5	2317	5	ABCC8	11	17434265	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	11386081	17434265	117572251	85	2629											
LRRC4C	57689	broad.mit.edu	37	chr11	40137138	40137138	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaaccctggaaagagccaggCctgatggcagataaatgatt	15	7	11	8	0	0	4	0	2	0	2	0	5	0	5	3	3	2	1	3	3	4	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr11:40137138C>A	uc001mxa.1	-	2	2669	c.705G>T	c.(703-705)AGG>AGT	p.R235S	LRRC4C_uc001mxc.1_Missense_Mutation_p.R231S|LRRC4C_uc001mxd.1_Missense_Mutation_p.R231S|LRRC4C_uc001mxb.1_Missense_Mutation_p.R231S	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	235	LRR 7.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				AAGAGCCAGGCCTGATGGCAG	0.463													29	151					2.65835e-16	2.98673e-16	1	0	A	40137138	A	A	40137138	3	1	10	1	0	0	0	0	1	0	0	0	9058	738	26	4	1221	4	LRRC4C	11	40137138	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	22702873	40137138	94869378	86	2630											
OR4C3	256144	broad.mit.edu	37	chr11	48346805	48346805	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attcttcttctatggctcctAaactcattgctgactcattg	8	17	5	11	0	5	1	2	1	3	0	6	1	6	1	1	1	2	2	1	1	3	7			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr11:48346805A>G	uc010rhv.1	+	1	313	c.313A>G	c.(313-315)AAA>GAA	p.K105E		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	78	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TATGGCTCCTAAACTCATTGC	0.463													15	313					0	0	0	0	G	48346805	G	G	48346805	3	3	10	1	0	0	0	0	1	0	0	0	11104	363	13	5	315	5	OR4C3	11	48346805	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	8209667	48346805	86659711	87	2631											
OR5D14	219436	broad.mit.edu	37	chr11	55563331	55563331	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttctactttagctgcatGatgcagtacttcctgtcctg	7	16	7	11	0	2	1	0	1	2	0	4	1	4	1	2	0	5	4	2	0	3	6			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr11:55563331G>T	uc010rim.1	+	1	300	c.300G>T	c.(298-300)ATG>ATT	p.M100I		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	100	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TTAGCTGCATGATGCAGTACT	0.458													43	110					1.03325e-14	1.14738e-14	1	0	T	55563331	T	T	55563331	3	4	10	1	0	0	0	0	1	0	0	0	11209	1290	45	2	302	2	OR5D14	11	55563331	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	7216526	55563331	79443185	88	2632											
GIF	2694	broad.mit.edu	37	chr11	59603312	59603312	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttttgcgctgtgcttcctCtaggacaacaagtaacactg	10	13	8	10	1	1	0	0	0	1	0	2	1	2	1	1	1	4	3	1	1	4	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr11:59603312C>G	uc001noi.2	-	7	1090	c.1042G>C	c.(1042-1044)GAG>CAG	p.E348Q		NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	348					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						TGTGCTTCCTCTAGGACAACA	0.413													106	292					0	0	0	0	G	59603312	G	G	59603312	3	3	10	1	0	0	0	0	1	0	0	0	6413	922	32	2	223	2	GIF	11	59603312	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	4039981	59603312	75403204	89	2633											
AHNAK	79026	broad.mit.edu	37	chr11	62294809	62294809	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatttgggccttccacagcTacttctggcatgtcagcatc	7	12	8	14	0	2	0	1	0	1	0	4	0	3	0	3	2	3	3	3	2	1	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr11:62294809T>C	uc001ntl.2	-	5	7380	c.7080A>G	c.(7078-7080)GTA>GTG	p.V2360V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2360					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTTCCACAGCTACTTCTGGCA	0.453													112	384					0	0	0	0	C	62294809	C	C	62294809	2	2	10	1	0	0	0	0	0	0	0	1	414	1509	53	5		5	AHNAK	11	62294809	Silent	SNP	T	TCGA-BA-5555-01A-01D-1512-08	2691497	62294809	72711707	90	2634											
KRTAP5-11	440051	broad.mit.edu	37	chr11	71293827	71293827	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagccacagcccccactgccGgagccacagcccccacagcc	9	1	9	22	1	0	0	0	0	0	0	0	2	0	1	8	1	6	0	8	1	0	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr11:71293827G>A	uc001oqu.2	-	1	95	c.57C>T	c.(55-57)TCC>TCT	p.S19S		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	19						keratin filament					0						CCCCACTGCCGGAGCCACAGC	0.632													22	45					0	0	0	0	A	71293827	A	A	71293827	2	1	10	1	0	0	0	0	0	0	0	1	8600	1103	39	1		1	KRTAP5-11	11	71293827	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	8999018	71293827	63712689	91	2635											
ST14	6768	broad.mit.edu	37	chr11	130058529	130058529	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actccactgagtttgtaagcCtggccagcaaggtgaaggac	11	8	12	10	0	0	2	0	2	0	0	1	3	1	3	3	3	2	3	3	3	3	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr11:130058529C>T	uc001qfw.2	+	3	539	c.346C>T	c.(346-348)CTG>TTG	p.L116L	ST14_uc010sca.1_5'Flank	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	116	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GTTTGTAAGCCTGGCCAGCAA	0.572													54	57					0	0	0	0	T	130058529	T	T	130058529	2	4	10	1	0	0	0	0	0	0	0	1	15277	680	24	4		4	ST14	11	130058529	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	58764702	130058529	4947987	92	2636											
GLB1L3	112937	broad.mit.edu	37	chr11	134153634	134153634	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcccctcttgcccccagctgGctcctgcaagacccccggtt	4	8	9	20	1	1	1	0	0	1	1	2	1	2	1	7	2	3	4	7	2	1	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr11:134153634G>C	uc009zdf.2	+	6	891	c.531G>C	c.(529-531)TGG>TGC	p.W177C	GLB1L3_uc010scs.1_Missense_Mutation_p.W177C|GLB1L3_uc010sct.1_Missense_Mutation_p.W29C	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	177					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CCCCCAGCTGGCTCCTGCAAG	0.592													7	8					0	0	0	0	C	134153634	C	C	134153634	3	2	10	1	0	0	0	0	1	0	0	0	6467	1212	42	4	553	4	GLB1L3	11	134153634	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	4095105	134153634	852882	93	2637											
KLRG1	10219	broad.mit.edu	37	chr12	9162052	9162052	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatagctttgtgcagacatgCggtgccatcaacaaaaatgg	14	9	10	8	1	1	1	1	0	0	1	1	1	1	1	1	2	5	2	1	2	5	2	rs145154967		TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:9162052C>A	uc001qvh.2	+	5	500	c.489C>A	c.(487-489)TGC>TGA	p.C163*	KLRG1_uc001qvg.2_Nonsense_Mutation_p.C163*	NM_005810	NP_005801	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G,	163	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			central_nervous_system(1)	1						TGCAGACATGCGGTGCCATCA	0.433													38	92					2.04263e-09	2.16746e-09	1	0	A	9162052	A	A	9162052	4	1	10	1	0	0	0	0	0	1	0	0	8460	776	27	3	507	3	KLRG1	12	9162052	Nonsense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08		9162052	124689843	94	2638											
LDHB	3945	broad.mit.edu	37	chr12	21791345	21791345	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actatcattgtcagttcccaTttctggattcaattcctgga	9	16	6	10	0	4	0	3	0	1	0	6	2	6	2	2	2	0	1	2	2	2	6			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:21791345T>C	uc001rfc.2	-	5	673	c.655A>G	c.(655-657)ATG>GTG	p.M219V	LDHB_uc001rfd.2_Missense_Mutation_p.M219V|LDHB_uc001rfe.2_Missense_Mutation_p.M219V	NM_002300	NP_002291	P07195	LDHB_HUMAN	L-lactate dehydrogenase B	219					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity			breast(2)|ovary(1)	3					NADH(DB00157)	TCAGTTCCCATTTCTGGATTC	0.358													57	122					0	0	0	0	C	21791345	C	C	21791345	3	2	10	1	0	0	0	0	1	0	0	0	8741	1493	52	5	361	5	LDHB	12	21791345	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	12629293	21791345	112060550	95	2639											
KIAA0528	9847	broad.mit.edu	37	chr12	22637814	22637814	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaacgtgtaggcaaatttTcttcaagcctatataaataa	16	12	5	8	1	2	0	1	0	1	0	2	0	2	0	1	1	2	2	1	1	9	8			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:22637814T>A	uc001rfq.2	-	13	1595	c.1367A>T	c.(1366-1368)GAA>GTA	p.E456V	KIAA0528_uc010sir.1_Missense_Mutation_p.E271V|KIAA0528_uc010sis.1_Missense_Mutation_p.E456V|KIAA0528_uc010sit.1_Missense_Mutation_p.E458V|KIAA0528_uc010siu.1_Missense_Mutation_p.E456V|KIAA0528_uc001rfr.2_Missense_Mutation_p.E447V|KIAA0528_uc009ziy.1_Missense_Mutation_p.E458V	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	456							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						AGGCAAATTTTCTTCAAGCCt	0.264													34	32					0	0	0	0	A	22637814	A	A	22637814	3	1	10	1	0	0	0	0	1	0	0	0	8221	1783	62	5	1687	5	KIAA0528	12	22637814	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	846469	22637814	111214081	96	2640											
AMIGO2	347902	broad.mit.edu	37	chr12	47472679	47472679	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggggcacaccccagaggcaCcagggcccacagtcactgtg	9	4	13	15	0	1	1	1	0	0	1	1	1	1	1	4	4	0	2	4	4	0	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:47472679C>G	uc001rpm.2	-	3	762	c.107G>C	c.(106-108)GGT>GCT	p.G36A	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Missense_Mutation_p.G36A|AMIGO2_uc001rpl.2_Missense_Mutation_p.G36A	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	36					heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)					CCCAGAGGCACCAGGGCCCAC	0.587													47	104					0	0	0	0	G	47472679	G	G	47472679	3	3	10	1	0	0	0	0	1	0	0	0	576	507	18	4	1465	4	AMIGO2	12	47472679	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	24834865	47472679	86379216	97	2641											
PTPRR	5801	broad.mit.edu	37	chr12	71158499	71158499	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcctaaagctgcagccacTccttggcggaagatccgaag	11	7	11	12	2	0	1	0	0	0	1	3	3	3	2	4	2	3	2	4	2	4	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:71158499T>G	uc001swi.1	-	3	833	c.417A>C	c.(415-417)GGA>GGC	p.G139G	PTPRR_uc010stq.1_Silent_p.G27G	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	139	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CTGCAGCCACTCCTTGGCGGA	0.408													63	91					0	0	0	0	G	71158499	G	G	71158499	2	3	10	1	0	0	0	0	0	0	0	1	12875	1538	54	5		5	PTPRR	12	71158499	Silent	SNP	T	TCGA-BA-5555-01A-01D-1512-08	23685820	71158499	62693396	98	2642											
ACSS3	79611	broad.mit.edu	37	chr12	81472119	81472119	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcctcggtgaccgaccccGagaggttctggggcaaagct	8	6	14	13	3	1	2	0	1	1	1	2	4	1	2	4	4	2	3	4	4	1	1	rs144134515		TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:81472119G>T	uc001szl.1	+	1	311	c.220G>T	c.(220-222)GAG>TAG	p.E74*	ACSS3_uc001szm.1_Nonsense_Mutation_p.E74*	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	74						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GACCGACCCCGAGAGGTTCTG	0.657													12	64					9.04627e-18	1.02848e-17	1	0	T	81472119	T	T	81472119	4	4	10	1	0	0	0	0	0	1	0	0	190	1059	37	3	222	3	ACSS3	12	81472119	Nonsense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	10313620	81472119	52379776	99	2643											
VEZT	55591	broad.mit.edu	37	chr12	95660258	95660258	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtcataagagctttgagatTatggaggacagccaaactac	14	9	11	7	0	1	2	1	1	0	2	1	5	1	4	1	3	4	1	1	3	4	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:95660258T>A	uc001tdz.2	+	5	665	c.560T>A	c.(559-561)TTA>TAA	p.L187*	VEZT_uc009zsy.1_Nonsense_Mutation_p.L29*|VEZT_uc001tdr.2_Nonsense_Mutation_p.L29*|VEZT_uc001tds.2_Nonsense_Mutation_p.L139*|VEZT_uc001tdt.2_Nonsense_Mutation_p.L139*|VEZT_uc009zsz.1_Nonsense_Mutation_p.L187*|VEZT_uc001tdv.2_Nonsense_Mutation_p.L156*|VEZT_uc001tdw.1_Nonsense_Mutation_p.L139*|VEZT_uc009zta.1_Nonsense_Mutation_p.L139*	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	187						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						GCTTTGAGATTATGGAGGACA	0.428													132	210					0	0	0	0	A	95660258	A	A	95660258	4	1	10	1	0	0	0	0	0	1	0	0	17224	1764	61	5	578	5	VEZT	12	95660258	Nonsense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	14188139	95660258	38191637	100	2644											
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100502306	100502319	+	Frame_Shift_Del	DEL	GGAGATAAATTTTT	-	-																															tacttagatttatcttgtcaGgagataaatttttggtaaat																										TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:100502306_100502319delGGAGATAAATTTTT	uc001tgq.2	-	2	281_294	c.52_65delAAAAATTTATCTCC	c.(52-66)AAAAATTTATCTCCTfs	p.K18fs	UHRF1BP1L_uc001tgr.2_Frame_Shift_Del_p.K18fs	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	18_22										ovary(2)	2						TATCTTGTCAGGAGATAAATTTTTGGTAAATCTG	0.313													---	---	---								-	100502319	-	-	100502306	7	5	10	1	0	1	0	1	0	0	0	0	17037	1000	35	0	4433	0	UHRF1BP1L	12	100502306	Frame_Shift_Del	DEL	GGAGATAAATTTTT	TCGA-BA-5555-01A-01D-1512-08	4842048	100502306	33349589	101	2645											
RFX4	5992	broad.mit.edu	37	chr12	107126787	107126787	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttctccagcaaaatctgcCacatctgtggaagtgccacc	10	11	7	13	0	3	0	0	0	3	0	4	1	3	1	4	1	3	1	4	1	3	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:107126787C>G	uc001tlr.2	+	15	1623	c.1557C>G	c.(1555-1557)GCC>GCG	p.A519A	RFX4_uc001tls.2_Silent_p.A528A|RFX4_uc001tlt.2_Silent_p.A528A|RFX4_uc001tlv.2_Silent_p.A425A	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	519					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						CAAAATCTGCCACATCTGTGG	0.507													74	122					0	0	0	0	G	107126787	G	G	107126787	2	3	10	1	0	0	0	0	0	0	0	1	13330	581	21	4		4	RFX4	12	107126787	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	6624481	107126787	26725108	102	2646											
KDM2B	84678	broad.mit.edu	37	chr12	121878774	121878774	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctgacagcaccaagtccCggagccctggggggacatag	10	4	14	13	1	0	1	0	1	0	0	1	3	1	3	4	4	3	1	4	4	2	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:121878774C>T	uc001uat.2	-	21	3559	c.3455G>A	c.(3454-3456)CGG>CAG	p.R1152Q	KDM2B_uc001uaq.2_Missense_Mutation_p.R592Q|KDM2B_uc010szy.1_Missense_Mutation_p.R592Q|KDM2B_uc001uar.2_Missense_Mutation_p.R743Q|KDM2B_uc001uas.2_Missense_Mutation_p.R1083Q|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_Missense_Mutation_p.R400Q|KDM2B_uc010szx.1_Missense_Mutation_p.R400Q|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	1152	LRR 2.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CACCAAGTCCCGGAGCCCTGG	0.647													14	66					0	0	0	0	T	121878774	T	T	121878774	3	4	10	1	0	0	0	0	1	0	0	0	8164	652	23	1	619	1	KDM2B	12	121878774	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	14751987	121878774	11973121	103	2647											
PIWIL1	9271	broad.mit.edu	37	chr12	130851726	130851726	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaagagtgaacaccagattTtttgctcagtctggaggaag	14	10	11	6	0	2	3	1	1	1	2	2	5	2	5	1	2	2	1	1	2	4	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr12:130851726T>G	uc001uik.2	+	19	2334	c.2244T>G	c.(2242-2244)TTT>TTG	p.F748L	PIWIL1_uc001uij.1_Missense_Mutation_p.F748L	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	748	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ACACCAGATTTTTTGCTCAGT	0.408													45	198					0	0	0	0	G	130851726	G	G	130851726	3	3	10	1	0	0	0	0	1	0	0	0	12012	1838	64	5	2314	5	PIWIL1	12	130851726	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	8972952	130851726	3000169	104	2648											
PCDH9	5101	broad.mit.edu	37	chr13	67799767	67799767	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcagatttgtagtgcttggCcaggtcaggactgttaggct	8	12	14	7	0	1	1	1	0	0	1	1	2	1	2	1	4	2	5	1	4	2	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr13:67799767C>A	uc001vik.2	-	2	3498	c.2806G>T	c.(2806-2808)GCC>TCC	p.A936S	PCDH9_uc001vil.2_Missense_Mutation_p.A936S|PCDH9_uc010thl.1_Missense_Mutation_p.A936S|PCDH9_uc001vin.3_Missense_Mutation_p.A936S	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	936	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TAGTGCTTGGCCAGGTCAGGA	0.502													67	88					5.26073e-25	6.16441e-25	1	0	A	67799767	A	A	67799767	3	1	10	1	0	0	0	0	1	0	0	0	11572	739	26	4	923	4	PCDH9	13	67799767	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08		67799767	47370111	105	2649											
SLITRK6	84189	broad.mit.edu	37	chr13	86369608	86369608	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatgttgcgctcctgacaatGtattagaagtcctgatgggg	10	12	12	7	1	0	3	0	2	0	1	2	3	2	3	2	2	1	3	2	2	5	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr13:86369608G>A	uc001vll.1	-	2	1495	c.1036C>T	c.(1036-1038)CAT>TAT	p.H346Y	SLITRK6_uc010afe.1_Missense_Mutation_p.H111Y	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	346	Extracellular (Potential).|LRRNT 2.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCCTGACAATGTATTAGAAGT	0.408													70	97					0	0	0	0	A	86369608	A	A	86369608	3	1	10	1	0	0	0	0	1	0	0	0	14811	1377	48	4	1493	4	SLITRK6	13	86369608	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	18569841	86369608	28800270	106	2650											
OR4M1	441670	broad.mit.edu	37	chr14	20248817	20248817	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttgttggggcttcggagatGttcttgctcacagtgatggc	5	15	14	7	1	2	2	1	1	1	1	3	3	2	2	0	4	1	4	0	4	0	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr14:20248817G>C	uc010tku.1	+	1	336	c.336G>C	c.(334-336)ATG>ATC	p.M112I		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTTCGGAGATGTTCTTGCTCA	0.478													153	598					0	0	0	0	C	20248817	C	C	20248817	3	2	10	1	0	0	0	0	1	0	0	0	11129	1377	48	4	338	4	OR4M1	14	20248817	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08		20248817	87100723	107	2651											
TEP1	7011	broad.mit.edu	37	chr14	20849089	20849089	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagccagtgactcatctcaCcatagagggcatgggcctcc	9	7	10	15	0	2	2	2	1	1	1	4	2	3	2	5	2	1	1	5	2	1	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr14:20849089C>T	uc001vxe.2	-	33	4802	c.4762_splice	c.e33+1	p.A1588_splice	TEP1_uc010ahk.2_Splice_Site_p.A931_splice|TEP1_uc010tlf.1_Splice_Site|TEP1_uc010tlg.1_Splice_Site_p.A1480_splice|TEP1_uc010tlh.1_Splice_Site	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1						telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		ACTCATCTCACCATAGAGGGC	0.577													23	70					0	0	0	0	T	20849089	T	T	20849089	5	4	10	1	0	0	0	0	0	0	1	0	15825	521	18	4	3212	4	TEP1	14	20849089	Splice_Site	SNP	C	TCGA-BA-5555-01A-01D-1512-08	600272	20849089	86500451	108	2652											
GOLGA5	9950	broad.mit.edu	37	chr14	93277936	93277936	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taataaagtggaaatggaacGtcagaatttagcagaagcaa	19	8	10	4	1	1	2	1	0	0	2	1	4	1	4	0	2	3	2	0	2	9	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr14:93277936G>A	uc001yaz.1	+	6	1339	c.1157G>A	c.(1156-1158)CGT>CAT	p.R386H		NM_005113	NP_005104	Q8TBA6	GOGA5_HUMAN	Golgi autoantigen, golgin subfamily a, 5	386	Cytoplasmic (Potential).|Potential.				Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			ovary(2)|lung(1)	3		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		GAAATGGAACGTCAGAATTTA	0.358			T	RET	papillary thyroid								42	120					0	0	0	0	A	93277936	A	A	93277936	3	1	10	1	0	0	0	0	1	0	0	0	6593	1145	40	1	1175	1	GOLGA5	14	93277936	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	72428847	93277936	14071604	109	2653											
RYR3	6263	broad.mit.edu	37	chr15	33936553	33936553	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtctatctcagatcggcCgcatgaatctcgggacagat	9	10	12	10	3	3	3	1	1	3	2	6	4	3	4	1	3	0	1	1	3	2	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr15:33936553C>A	uc001zhi.2	+	28	3668	c.3598C>A	c.(3598-3600)CGC>AGC	p.R1200S	RYR3_uc010bar.2_Missense_Mutation_p.R1200S	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1200	B30.2/SPRY 2.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCAGATCGGCCGCATGAATCT	0.517													13	9					1.05317e-09	1.12377e-09	1	0	A	33936553	A	A	33936553	3	1	10	1	0	0	0	0	1	0	0	0	13835	652	23	3	3708	3	RYR3	15	33936553	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08		33936553	68594839	110	2654											
ACTC1	70	broad.mit.edu	37	chr15	35086967	35086967	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccttcaccagcccagagcCgttgtcgcacaccagggcgg	7	5	13	16	3	1	1	1	0	0	1	2	1	1	1	5	3	2	2	5	3	0	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr15:35086967C>A	uc001ziu.1	-	2	286	c.43G>T	c.(43-45)GGC>TGC	p.G15C	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	15					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		AGCCCAGAGCCGTTGTCGCAC	0.677													61	59					2.79145e-41	3.50768e-41	1	0	A	35086967	A	A	35086967	3	1	10	1	0	0	0	0	1	0	0	0	195	652	23	3	1114	3	ACTC1	15	35086967	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	1150414	35086967	67444425	111	2655											
ITPKA	3706	broad.mit.edu	37	chr15	41795316	41795316	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcgaggacggctatttgctGgggctggacaatctcattgg	7	10	15	9	3	1	0	1	0	1	0	2	3	1	2	0	6	1	3	0	6	2	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr15:41795316G>A	uc001znz.2	+	7	1349	c.1338G>A	c.(1336-1338)CTG>CTA	p.L446L		NM_002220	NP_002211	P23677	IP3KA_HUMAN	1D-myo-inositol-trisphosphate 3-kinase A	446					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		GCTATTTGCTGGGGCTGGACA	0.662													19	16					0	0	0	0	A	41795316	A	A	41795316	2	1	10	1	0	0	0	0	0	0	0	1	7956	1335	47	4		4	ITPKA	15	41795316	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	6708349	41795316	60736076	112	2656											
ZFP106	64397	broad.mit.edu	37	chr15	42749328	42749328	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacccacttctgtgacccCgcacactcggcactcatgac	10	7	7	17	2	2	3	1	2	1	1	3	3	2	3	3	1	0	2	3	1	1	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr15:42749328C>A	uc001zpw.2	-	1	411	c.76G>T	c.(76-78)GGG>TGG	p.G26W	ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Intron|ZFP106_uc001zpy.1_Missense_Mutation_p.G49W	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	26	C2H2-type 1; atypical.					nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		TCTGTGACCCCGCACACTCGG	0.438													19	52					4.96729e-08	5.24173e-08	1	0	A	42749328	A	A	42749328	3	1	10	1	0	0	0	0	1	0	0	0	17704	652	23	3	5651	3	ZFP106	15	42749328	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	954012	42749328	59782064	113	2657											
THSD4	79875	broad.mit.edu	37	chr15	72023481	72023481	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgatacaccagcagccaaacCcaggcgtgcactacgagtac	13	5	9	14	2	0	1	0	1	0	0	0	2	0	1	3	1	7	3	3	1	4	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr15:72023481C>A	uc002atb.1	+	9	1634	c.1555C>A	c.(1555-1557)CCA>ACA	p.P519T	THSD4_uc002atd.1_3'UTR|THSD4_uc010ukg.1_Missense_Mutation_p.P159T|THSD4_uc002ate.2_Missense_Mutation_p.P159T	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	519						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						GCAGCCAAACCCAGGCGTGCA	0.552											OREG0023247	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	67					4.36969e-10	4.68883e-10	1	0	A	72023481	A	A	72023481	3	1	10	1	0	0	0	0	1	0	0	0	15944	623	22	4	1589	4	THSD4	15	72023481	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	29274153	72023481	30507911	114	2658											
AKAP13	11214	broad.mit.edu	37	chr15	86260576	86260576	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattcctgtctcattcaacaGactcactaaataaaatcagc	16	11	3	11	0	4	1	4	0	1	1	6	1	5	1	1	0	2	0	1	0	6	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr15:86260576G>A	uc002blv.1	+	21	5961	c.5791G>A	c.(5791-5793)GAC>AAC	p.D1931N	AKAP13_uc002blu.1_Missense_Mutation_p.D1935N|AKAP13_uc010bnf.1_Missense_Mutation_p.D552N|AKAP13_uc002blw.1_Missense_Mutation_p.D398N|AKAP13_uc002blx.1_Missense_Mutation_p.D176N	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1931	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						TCATTCAACAGACTCACTAAA	0.378													26	39					0	0	0	0	A	86260576	A	A	86260576	3	1	10	1	0	0	0	0	1	0	0	0	449	942	33	2	5939	2	AKAP13	15	86260576	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	14237095	86260576	16270816	115	2659											
ZNF263	10127	broad.mit.edu	37	chr16	3340026	3340026	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacagttccaacctccttcGgcaccagagaattcacactg	11	9	6	15	1	2	1	2	0	0	1	5	2	4	1	4	1	1	2	4	1	2	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr16:3340026G>A	uc002cuq.2	+	6	1852	c.1520G>A	c.(1519-1521)CGG>CAG	p.R507Q	ZNF263_uc010uww.1_Missense_Mutation_p.R155Q|ZNF263_uc002cur.2_Missense_Mutation_p.R155Q	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	507	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						AACCTCCTTCGGCACCAGAGA	0.522													20	58					0	0	0	0	A	3340026	A	A	3340026	3	1	10	1	0	0	0	0	1	0	0	0	17870	1116	39	1	1542	1	ZNF263	16	3340026	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08		3340026	87014727	116	2660											
PDZD9	255762	broad.mit.edu	37	chr16	21995735	21995735	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtatggagaaggggccctCacttctttcttgtcgtctct	6	14	10	11	1	4	1	1	0	3	1	6	2	4	1	1	3	0	1	1	3	2	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr16:21995735C>A	uc002dka.1	-	5	779	c.462G>T	c.(460-462)GTG>GTT	p.V154V		NM_173806	NP_776167	Q8IXQ8	PDZD9_HUMAN	hypothetical protein LOC255762	216										pancreas(1)	1						AAGGGGCCCTCACTTCTTTCT	0.433													164	349					6.73164e-69	8.86719e-69	1	0	A	21995735	A	A	21995735	2	1	10	1	0	0	0	0	0	0	0	1	11760	813	29	2		2	PDZD9	16	21995735	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	18655709	21995735	68359018	117	2661											
VWA3A	146177	broad.mit.edu	37	chr16	22130326	22130326	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacagcagcccctgtgaggCgctcacctgcaccatggagg	8	5	13	15	1	1	1	1	1	0	0	1	2	1	2	4	3	3	4	4	3	0	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr16:22130326C>A	uc010vbq.1	+	12	1190	c.1094C>A	c.(1093-1095)GCG>GAG	p.A365E	VWA3A_uc010bxd.2_5'Flank|VWA3A_uc010bxc.2_Missense_Mutation_p.A352E	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	365						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		CCCTGTGAGGCGCTCACCTGC	0.612													9	25					2.17888e-05	2.26177e-05	1	0	A	22130326	A	A	22130326	3	1	10	1	0	0	0	0	1	0	0	0	17308	768	27	3	1140	3	VWA3A	16	22130326	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	134591	22130326	68224427	118	2662											
CDH5	1003	broad.mit.edu	37	chr16	66426206	66426206	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcagcctttctaccacttCcagctgaaggaaaaccagaa	14	7	7	13	0	1	2	0	1	1	1	2	3	2	3	4	1	5	2	4	1	5	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr16:66426206C>A	uc002eom.3	+	7	1293	c.1137C>A	c.(1135-1137)TTC>TTA	p.F379L	CDH5_uc002eon.1_Missense_Mutation_p.F379L	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	379	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		TCTACCACTTCCAGCTGAAGG	0.552													67	120					1.26778e-28	1.52293e-28	1	0	A	66426206	A	A	66426206	3	1	10	1	0	0	0	0	1	0	0	0	3128	854	30	2	1159	2	CDH5	16	66426206	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	44295880	66426206	23928547	119	2663											
HYDIN	54768	broad.mit.edu	37	chr16	70852359	70852359	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaacttgatggaggctgaCgcaacttgccggactggggt	8	9	14	10	2	0	2	0	2	0	0	1	4	1	4	2	5	3	2	2	5	2	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr16:70852359C>T	uc002ezr.2	-	84	14669	c.14541G>A	c.(14539-14541)GCG>GCA	p.A4847A	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4848										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TGGAGGCTGACGCAACTTGCC	0.547													12	15					0	0	0	0	T	70852359	T	T	70852359	2	4	10	1	0	0	0	0	0	0	0	1	7506	523	19	1		1	HYDIN	16	70852359	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	4426153	70852359	19502394	120	2664											
SHPK	23729	broad.mit.edu	37	chr17	3526640	3526640	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgtgatactcacgtctctaCgttccagctttggctctgcg	6	14	9	12	3	3	1	1	1	2	0	5	1	4	1	1	1	4	3	1	1	2	4	rs111475678		TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr17:3526640C>A	uc002fvz.1	-	4	743	c.640G>T	c.(640-642)GTA>TTA	p.V214L		NM_013276	NP_037408	Q9UHJ6	SHPK_HUMAN	carbohydrate kinase-like	214					carbohydrate metabolic process	cytoplasm	ATP binding|sedoheptulokinase activity			ovary(1)	1				COAD - Colon adenocarcinoma(5;0.0828)		CACGTCTCTACGTTCCAGCTT	0.557													129	73					4.27115e-56	5.54959e-56	1	0	A	3526640	A	A	3526640	3	1	10	1	0	0	0	0	1	0	0	0	14355	536	19	3	812	3	SHPK	17	3526640	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08		3526640	77668570	121	2665											
TP53	7157	broad.mit.edu	37	chr17	7577574	7577574	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcaggaactgttacacatgTagttgtagtggatggtggta	10	13	14	4	0	0	0	0	0	0	0	0	2	0	2	0	4	3	6	0	4	5	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr17:7577574T>C	uc002gim.2	-	7	901	c.707A>G	c.(706-708)TAC>TGC	p.Y236C	TP53_uc002gig.1_Missense_Mutation_p.Y236C|TP53_uc002gih.2_Missense_Mutation_p.Y236C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y104C|TP53_uc010cng.1_Missense_Mutation_p.Y104C|TP53_uc002gii.1_Missense_Mutation_p.Y104C|TP53_uc010cnh.1_Missense_Mutation_p.Y236C|TP53_uc010cni.1_Missense_Mutation_p.Y236C|TP53_uc002gij.2_Missense_Mutation_p.Y236C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y143C|TP53_uc002gio.2_Missense_Mutation_p.Y104C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	236	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> S (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y236C(46)|p.Y236N(12)|p.Y236*(9)|p.Y236H(9)|p.0?(7)|p.Y236D(6)|p.Y236del(4)|p.Y236S(3)|p.Y236Y(2)|p.Y236fs*4(2)|p.Y236_M237delYM(1)|p.I232_Y236delIHYNY(1)|p.Y236fs*5(1)|p.H233fs*6(1)|p.Y236_M237insXX(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.N235_Y236delNY(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTACACATGTAGTTGTAGTG	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			40	32					0	0	0	0	C	7577574	C	C	7577574	3	2	10	1	0	0	0	0	1	0	0	0	16448	1638	57	5	583	5	TP53	17	7577574	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	4050934	7577574	73617636	122	2666											
RNFT1	51136	broad.mit.edu	37	chr17	58040557	58040557	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcactgcttccagttcctgGaggactgtgcagttggctac	6	12	11	12	0	1	0	1	0	0	0	3	2	3	2	2	3	3	5	2	3	1	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr17:58040557G>A	uc002iya.2	-	2	238	c.145C>T	c.(145-147)CCA>TCA	p.P49S	uc002iye.1_5'Flank|RNFT1_uc002iyb.2_RNA|RNFT1_uc002iyc.2_5'UTR|RNFT1_uc010wop.1_Missense_Mutation_p.P49S|RNFT1_uc002iyd.3_Missense_Mutation_p.P49S	NM_016125	NP_057209	Q5M7Z0	RNFT1_HUMAN	PTD016 protein	49						integral to membrane	zinc ion binding				0	all_cancers(5;1.58e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;7.95e-12)|all cancers(12;1.34e-10)			CCAGTTCCTGGAGGACTGTGC	0.483													81	67					0	0	0	0	A	58040557	A	A	58040557	3	1	10	1	0	0	0	0	1	0	0	0	13566	1174	41	2	1194	2	RNFT1	17	58040557	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	50462983	58040557	23154653	123	2667											
FASN	2194	broad.mit.edu	37	chr17	80041948	80041948	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggatgagcagcgtctccccGgggcgcacccgcccacgcac	6	4	13	18	5	1	1	0	1	1	0	2	2	1	2	4	3	2	3	4	3	0	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr17:80041948G>A	uc002kdu.2	-	29	5118	c.5001C>T	c.(4999-5001)CCC>CCT	p.P1667P	FASN_uc002kdv.1_5'Flank	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	1667	Enoyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GCGTCTCCCCGGGGCGCACCC	0.721													3	4					0	0	0	0	A	80041948	A	A	80041948	2	1	10	1	0	0	0	0	0	0	0	1	5715	1103	39	1		1	FASN	17	80041948	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	22001391	80041948	1153262	124	2668											
LAMA1	284217	broad.mit.edu	37	chr18	6999495	6999495	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggttcacactcatcgcaccGgagccccgaggcccccagcc	7	4	10	20	4	2	0	2	0	0	0	3	2	2	1	6	3	2	2	6	3	0	1	rs149937004		TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr18:6999495G>A	uc002knm.2	-	32	4706	c.4612C>T	c.(4612-4614)CGG>TGG	p.R1538W	LAMA1_uc010wzj.1_Missense_Mutation_p.R1014W	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1538	Laminin EGF-like 17.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCATCGCACCGGAGCCCCGAG	0.537													7	31					0	0	0	0	A	6999495	A	A	6999495	3	1	10	1	0	0	0	0	1	0	0	0	8645	1115	39	1	4743	1	LAMA1	18	6999495	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08		6999495	71077753	125	2669											
CEP192	55125	broad.mit.edu	37	chr18	13069788	13069788	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atccaaagaatctactccttAaacctggagaagaacatgag	17	8	7	9	0	1	4	0	1	1	3	3	5	3	4	3	1	3	0	3	1	7	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr18:13069788A>T	uc010xac.1	+	27	5187	c.5107A>T	c.(5107-5109)AAA>TAA	p.K1703*	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Nonsense_Mutation_p.K1228*|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Nonsense_Mutation_p.K125*|CEP192_uc002krw.2_5'UTR	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1703										ovary(4)|pancreas(1)	5						TCTACTCCTTAAACCTGGAGA	0.338													56	158					0	0	0	0	T	13069788	T	T	13069788	4	4	10	1	0	0	0	0	0	1	0	0	3266	363	13	5	5209	5	CEP192	18	13069788	Nonsense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	6070293	13069788	65007460	126	2670											
MC5R	4161	broad.mit.edu	37	chr18	13825564	13825564	+	5'Flank	DEL	A	-	-																															atagggagaccctgtctcttAaaaaaaaaaaaaaaaaagga																								rs33981843		TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr18:13825564delA	uc010xaf.1	+							NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor						G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						cctgtctcttaaaaaaaaaaa	0.224													---	---	---								-	13825564	-	-	13825564	6	5	10	0	1	1	0	1	0	0	0	0	9420	377	13	0		0	MC5R	18	13825564	5'Flank	DEL	A	TCGA-BA-5555-01A-01D-1512-08	755776	13825564	64251684	127	2671											
SMAD4	4089	broad.mit.edu	37	chr18	48604809	48604809	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaagtacttcataccatgcCgattgcagacccacaacctt	12	9	6	14	2	1	1	1	0	0	1	1	3	1	1	4	0	5	2	4	0	4	5			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr18:48604809C>T	uc010xdp.1	+	12	2169	c.1631C>T	c.(1630-1632)CCG>CTG	p.P544L	SMAD4_uc002lfb.3_Missense_Mutation_p.P389L	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	544	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CATACCATGCCGATTGCAGAC	0.463									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				6	139					0	0	0	0	T	48604809	T	T	48604809	3	4	10	1	0	0	0	0	1	0	0	0	14824	652	23	1	1673	1	SMAD4	18	48604809	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	34779245	48604809	29472439	128	2672											
SERPINB8	5271	broad.mit.edu	37	chr18	61654402	61654402	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgtggtcaggaattccCggtgcagcagaatggagcca	9	8	14	10	1	1	1	1	0	0	1	2	3	2	3	2	4	4	3	2	4	2	1	rs150328649	byFrequency	TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr18:61654402C>T	uc002ljv.2	+	7	1184	c.1015C>T	c.(1015-1017)CGG>TGG	p.R339W	SERPINB8_uc002lju.2_Missense_Mutation_p.R339W|SERPINB8_uc010xex.1_Missense_Mutation_p.R157W	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	339		Reactive bond (By similarity).			regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				CAGGAATTCCCGGTGCAGCAG	0.532													19	59					0	0	0	0	T	61654402	T	T	61654402	3	4	10	1	0	0	0	0	1	0	0	0	14172	643	23	1	1050	1	SERPINB8	18	61654402	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	13049593	61654402	16422846	129	2673											
CDH7	1005	broad.mit.edu	37	chr18	63511092	63511092	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttacacgctacggatagaAgctgcaaataaagatgccga	16	7	10	8	3	0	2	0	0	0	2	0	4	0	3	1	1	5	4	1	1	7	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr18:63511092A>T	uc002ljz.2	+	7	1351	c.1026A>T	c.(1024-1026)GAA>GAT	p.E342D	CDH7_uc002lka.2_Missense_Mutation_p.E342D|CDH7_uc002lkb.2_Missense_Mutation_p.E342D	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	342	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TACGGATAGAAGCTGCAAATA	0.443													47	95					0	0	0	0	T	63511092	T	T	63511092	3	4	10	1	0	0	0	0	1	0	0	0	3130	69	3	5	1048	5	CDH7	18	63511092	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	1856690	63511092	14566156	130	2674											
CDH7	1005	broad.mit.edu	37	chr18	63529970	63529970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aacaatcagtttactatctgCcaattttcattgtggacagt	12	15	6	8	0	3	0	2	0	1	0	3	1	3	1	1	1	3	1	1	1	5	6			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr18:63529970C>T	uc002ljz.2	+	11	2006	c.1681C>T	c.(1681-1683)CCA>TCA	p.P561S	CDH7_uc002lka.2_Missense_Mutation_p.P561S|CDH7_uc002lkb.2_Missense_Mutation_p.P561S	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	561	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TTACTATCTGCCAATTTTCAT	0.498													26	74					0	0	0	0	T	63529970	T	T	63529970	3	4	10	1	0	0	0	0	1	0	0	0	3130	739	26	4	1719	4	CDH7	18	63529970	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	18878	63529970	14547278	131	2675											
ZNF516	9658	broad.mit.edu	37	chr18	74154265	74154265	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctggccacacacctcgcacGggaactccccggggctcagc	7	4	11	19	3	1	0	1	0	0	0	3	1	2	1	5	4	2	2	5	4	1	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr18:74154265G>A	uc010dqx.1	-	2	981	c.746C>T	c.(745-747)CCG>CTG	p.P249L	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	249	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CACCTCGCACGGGAACTCCCC	0.687													16	34					0	0	0	0	A	74154265	A	A	74154265	3	1	10	1	0	0	0	0	1	0	0	0	18027	1116	39	1	2766	1	ZNF516	18	74154265	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	10624295	74154265	3922983	132	2676											
SALL3	27164	broad.mit.edu	37	chr18	76754386	76754386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctgagcagctacgatgacGacatggacgagaactccatg	12	6	11	12	3	0	3	0	2	0	1	1	7	1	4	2	1	4	2	2	1	2	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr18:76754386G>A	uc002lmt.2	+	2	2395	c.2395G>A	c.(2395-2397)GAC>AAC	p.D799N	SALL3_uc010dra.2_Missense_Mutation_p.D406N	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	799				DDDMDE -> NDNLDK (in Ref. 2; CAB65124).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CTACGATGACGACATGGACGA	0.662													15	47					0	0	0	0	A	76754386	A	A	76754386	3	1	10	1	0	0	0	0	1	0	0	0	13877	1058	37	1	2401	1	SALL3	18	76754386	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	2600121	76754386	1322862	133	2677											
MUC16	94025	broad.mit.edu	37	chr19	9014654	9014654	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggcttttggggtcaagaCggtgggtgcagatggcatcc	7	9	17	8	1	1	2	1	0	0	2	2	2	2	2	1	6	1	3	1	6	1	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr19:9014654C>T	uc002mkp.2	-	31	38525	c.38321G>A	c.(38320-38322)CGT>CAT	p.R12774H	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12776	SEA 5.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGGTCAAGACGGTGGGTGCA	0.567													13	56					0	0	0	0	T	9014654	T	T	9014654	3	4	10	1	0	0	0	0	1	0	0	0	10026	536	19	1	5418	1	MUC16	19	9014654	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08		9014654	50114329	134	2678											
ICAM1	3383	broad.mit.edu	37	chr19	10394262	10394262	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggcaccccgggccaaccTcaccgtggtgctgctccgtg	4	7	14	16	3	1	0	1	0	0	0	2	0	2	0	6	4	3	3	6	4	1	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr19:10394262T>A	uc002mnq.2	+	3	756	c.437T>A	c.(436-438)CTC>CAC	p.L146H	ICAM1_uc010xle.1_Intron	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	146	Ig-like C2-type 2.|Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	CGGGCCAACCTCACCGTGGTG	0.667													8	50					0	0	0	0	A	10394262	A	A	10394262	3	1	10	1	0	0	0	0	1	0	0	0	7518	1551	54	5	447	5	ICAM1	19	10394262	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	1379608	10394262	48734721	135	2679											
MYO9B	4650	broad.mit.edu	37	chr19	17283733	17283733	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccatggcagtgcttcgggagGccggacgcctgcgggccgag	5	5	18	13	5	0	0	0	0	0	0	1	3	0	2	4	5	2	2	4	5	0	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr19:17283733G>A	uc010eak.2	+	13	2253	c.2101G>A	c.(2101-2103)GCC>ACC	p.A701T	MYO9B_uc002nfi.2_Missense_Mutation_p.A701T|MYO9B_uc002nfj.1_Missense_Mutation_p.A701T	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	701	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GCTTCGGGAGGCCGGACGCCT	0.687													4	33					0	0	0	0	A	17283733	A	A	17283733	3	1	10	1	0	0	0	0	1	0	0	0	10138	1203	42	4	2147	4	MYO9B	19	17283733	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	6889471	17283733	41845250	136	2680											
UPF1	5976	broad.mit.edu	37	chr19	18958606	18958606	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttactgtaataccagcaagaAgtggttctgcaacggacgtg	12	10	11	8	2	1	1	0	0	1	1	1	2	1	2	1	2	5	4	1	2	6	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr19:18958606A>G	uc002nkg.2	+	3	700	c.425A>G	c.(424-426)AAG>AGG	p.K142R	UPF1_uc002nkf.2_Missense_Mutation_p.K142R	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	142	C2H2-type; atypical.|Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ACCAGCAAGAAGTGGTTCTGC	0.428											OREG0025373	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	99					0	0	0	0	G	18958606	G	G	18958606	3	3	10	1	0	0	0	0	1	0	0	0	17071	72	3	5	435	5	UPF1	19	18958606	Missense_Mutation	SNP	A	TCGA-BA-5555-01A-01D-1512-08	1674873	18958606	40170377	137	2681											
LGALS7B	653499	broad.mit.edu	37	chr19	39281521	39281521	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcatcgcgtcagacgaCggcttcaaggtgcgtctctg	7	10	11	13	5	5	1	4	0	1	1	7	2	5	1	0	2	1	1	0	2	1	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr19:39281521C>T	uc002ojf.3	+	3	305	c.288C>T	c.(286-288)GAC>GAT	p.D96D		NM_001042507	NP_001035972	P47929	LEG7_HUMAN	galectin-7B	96	Galectin.				apoptosis|heterophilic cell-cell adhesion	cytoplasm|extracellular space|nucleus	sugar binding				0						CGTCAGACGACGGCTTCAAGG	0.657													5	14					0	0	0	0	T	39281521	T	T	39281521	2	4	10	1	0	0	0	0	0	0	0	1	8787	535	19	1		1	LGALS7B	19	39281521	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	20322915	39281521	19847462	138	2682											
FBL	2091	broad.mit.edu	37	chr19	40327295	40327295	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggccacatcagcaaagatCacatccaccattgctaagga	14	7	8	12	0	2	1	2	0	0	1	3	2	3	2	3	2	2	2	3	2	2	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr19:40327295C>A	uc002omn.2	-	7	810	c.696G>T	c.(694-696)GTG>GTT	p.V232V	DYRK1B_uc002omi.2_5'Flank|DYRK1B_uc002omj.2_5'Flank|DYRK1B_uc002omk.2_5'Flank|DYRK1B_uc002oml.2_5'Flank|FBL_uc002omm.1_Silent_p.V146V|FBL_uc002omo.2_Silent_p.V231V	NM_001436	NP_001427	P22087	FBRL_HUMAN	fibrillarin	232					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			ovary(1)	1	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		CAGCAAAGATCACATCCACCA	0.537													21	37					2.37509e-13	2.59224e-13	1	0	A	40327295	A	A	40327295	2	1	10	1	0	0	0	0	0	0	0	1	5728	813	29	2		2	FBL	19	40327295	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	1045774	40327295	18801688	139	2683											
KCNC3	3748	broad.mit.edu	37	chr19	50826517	50826517	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgagcccggttgcgggggccGggggatgtgtttgttcttct	2	12	18	9	4	2	0	0	0	2	0	2	2	2	1	2	5	2	3	2	5	0	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr19:50826517G>A	uc002pru.1	-	2	1988	c.1693C>T	c.(1693-1695)CGG>TGG	p.R565W	KCNC3_uc002prt.1_Missense_Mutation_p.R201W	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	565	Cytoplasmic (Potential).				cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		TGCGGGGGCCGGGGGATGTGT	0.662													16	8					0	0	0	0	A	50826517	A	A	50826517	3	1	10	1	0	0	0	0	1	0	0	0	8055	1115	39	1	592	1	KCNC3	19	50826517	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	10499222	50826517	8302466	140	2684											
ZNF419	79744	broad.mit.edu	37	chr19	58005043	58005043	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggagaaaggccttacaagtGcagcgactgtgggaaatttt	12	10	13	6	1	0	1	0	0	0	1	0	4	0	2	1	3	3	1	1	3	4	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr19:58005043G>A	uc002qov.2	+	5	1358	c.1118G>A	c.(1117-1119)TGC>TAC	p.C373Y	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Missense_Mutation_p.C374Y|ZNF419_uc010etz.1_Missense_Mutation_p.C361Y|ZNF419_uc010eua.1_Missense_Mutation_p.C360Y|ZNF419_uc002qow.2_Missense_Mutation_p.C341Y|ZNF419_uc010eub.1_Missense_Mutation_p.C328Y|ZNF419_uc010euc.1_Missense_Mutation_p.C327Y	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	373	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		CCTTACAAGTGCAGCGACTGT	0.413													61	98					0	0	0	0	A	58005043	A	A	58005043	3	1	10	1	0	0	0	0	1	0	0	0	17963	1319	46	4	1139	4	ZNF419	19	58005043	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	7178526	58005043	1123940	141	2685											
ADAM33	80332	broad.mit.edu	37	chr20	3655704	3655704	+	Frame_Shift_Del	DEL	C	-	-																															ggggccagcaccactggctgCccatctgggccgtagtgggt																										TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr20:3655704delC	uc002wit.2	-	4	390	c.303delG	c.(301-303)GGGfs	p.G101fs	ADAM33_uc002wir.1_Frame_Shift_Del_p.G101fs|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Frame_Shift_Del_p.G101fs|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Frame_Shift_Del_p.G100fs|ADAM33_uc010zqg.1_Frame_Shift_Del_p.G100fs|ADAM33_uc010zqh.1_Frame_Shift_Del_p.G101fs	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	101	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						CCACTGGCTGCCCATCTGGGC	0.612													---	---	---								-	3655704	-	-	3655704	7	5	10	1	0	1	0	1	0	0	0	0	250	726	26	0	2214	0	ADAM33	20	3655704	Frame_Shift_Del	DEL	C	TCGA-BA-5555-01A-01D-1512-08		3655704	59369816	142	2686											
TOP1	7150	broad.mit.edu	37	chr20	39706251	39706251	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctggggatgcaaaaataaaGaaggagaaggaaaatggctt	18	7	13	3	0	1	2	0	0	1	2	1	5	1	4	0	5	1	2	0	5	8	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr20:39706251G>A	uc002xjl.2	+	5	555	c.309G>A	c.(307-309)AAG>AAA	p.K103K	TOP1_uc010gge.1_RNA	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	103	Lys-rich.			K->R: Localizes in both nucleoplasm and nucleoli; when associated with R-117 or R-153. Almost complete loss of sumoylation, concentrates in nucleoli and no clearing from nucleoli on CPT treatment; when associated with R-117 and R-153.	DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	CAAAAATAAAGAAGGAGAAGG	0.438			T	NUP98	AML*								81	71					0	0	0	0	A	39706251	A	A	39706251	2	1	10	1	0	0	0	0	0	0	0	1	16430	933	33	2		2	TOP1	20	39706251	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	36050547	39706251	23319269	143	2687											
MATN4	8785	broad.mit.edu	37	chr20	43933064	43933064	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcggccacgcggtcctggggCcgcccgtctgtcacgatgac	4	7	14	16	6	2	1	1	1	1	0	4	2	3	1	4	4	0	0	4	4	0	0			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr20:43933064C>T	uc002xnn.2	-	3	634	c.447G>A	c.(445-447)CGG>CGA	p.R149R	MATN4_uc002xno.2_Silent_p.R149R|MATN4_uc002xnp.2_Silent_p.R149R|MATN4_uc010zwr.1_Silent_p.R97R|MATN4_uc002xnr.1_Silent_p.R149R|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	149	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				GGTCCTGGGGCCGCCCGTCTG	0.721													6	7					0	0	0	0	T	43933064	T	T	43933064	2	4	10	1	0	0	0	0	0	0	0	1	9389	726	26	4		4	MATN4	20	43933064	Silent	SNP	C	TCGA-BA-5555-01A-01D-1512-08	4226813	43933064	19092456	144	2688											
PIGT	51604	broad.mit.edu	37	chr20	44045291	44045291	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccttcctgcaggccccaTcaggtgcagagctgtgggtc	6	8	12	15	0	1	1	1	0	0	1	3	1	2	1	4	3	3	3	4	3	0	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr20:44045291T>A	uc002xoh.1	+	2	395	c.322T>A	c.(322-324)TCA>ACA	p.S108T	PIGT_uc010ghb.1_Missense_Mutation_p.S108T|PIGT_uc010zwt.1_RNA|PIGT_uc010ghd.1_Intron|PIGT_uc010ghc.1_RNA|PIGT_uc010ghe.1_Missense_Mutation_p.S108T|PIGT_uc010ghf.1_Missense_Mutation_p.S108T|PIGT_uc002xoj.1_Missense_Mutation_p.S108T|PIGT_uc002xok.1_Missense_Mutation_p.S108T|PIGT_uc010zwu.1_5'UTR|PIGT_uc002xoi.1_RNA|PIGT_uc010zwv.1_Intron|PIGT_uc010zww.1_Missense_Mutation_p.S108T|PIGT_uc010zwx.1_5'UTR|PIGT_uc010zwy.1_Intron|PIGT_uc010zwz.1_Intron|PIGT_uc010zxa.1_5'UTR|PIGT_uc002xol.1_5'Flank	NM_015937	NP_057021	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	108	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			pancreas(1)	1		Myeloproliferative disorder(115;0.0122)				GCAGGCCCCATCAGGTGCAGA	0.582													7	35					0	0	0	0	A	44045291	A	A	44045291	3	1	10	1	0	0	0	0	1	0	0	0	11954	1435	50	5	328	5	PIGT	20	44045291	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	112227	44045291	18980229	145	2689											
KCNB1	3745	broad.mit.edu	37	chr20	47991215	47991215	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcggaagatctggaccacGcggcggacattctggaattg	10	8	14	9	4	2	1	0	0	2	1	2	5	2	5	1	5	1	0	1	5	2	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr20:47991215G>A	uc002xur.1	-	2	1046	c.882C>T	c.(880-882)CGC>CGT	p.R294R	KCNB1_uc002xus.1_Silent_p.R294R	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	294					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity	p.R294R(1)		pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCTGGACCACGCGGCGGACAT	0.532													9	78					0	0	0	0	A	47991215	A	A	47991215	2	1	10	1	0	0	0	0	0	0	0	1	8051	1074	38	1		1	KCNB1	20	47991215	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	3945924	47991215	15034305	146	2690											
HSPA13	6782	broad.mit.edu	37	chr21	15753858	15753858	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaacaggagagtcaaaacaGccgatcctgaaataaaggaa	19	4	9	9	1	1	2	1	1	0	1	2	5	2	3	3	2	3	0	3	2	7	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr21:15753858G>A	uc002yjt.2	-	2	101	c.32C>T	c.(31-33)GCT>GTT	p.A11V	HSPA13_uc011abx.1_5'UTR	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	11						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						AGTCAAAACAGCCGATCCTGA	0.363													3	18					0	0	0	0	A	15753858	A	A	15753858	3	1	10	1	0	0	0	0	1	0	0	0	7445	971	34	4	1399	4	HSPA13	21	15753858	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08		15753858	32376037	147	2691											
C21orf7	56911	broad.mit.edu	37	chr21	30521536	30521536	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccccctgaagactccattCctttggtctttccagaatta	9	13	5	14	0	1	3	0	1	1	2	4	3	4	3	5	1	0	0	5	1	3	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr21:30521536C>T	uc002yne.2	+	6	668	c.397C>T	c.(397-399)CCT>TCT	p.P133S	C21orf7_uc011acr.1_RNA|C21orf7_uc002ynd.2_RNA|C21orf7_uc010gln.2_RNA|C21orf7_uc002ynf.2_Missense_Mutation_p.P133S|C21orf7_uc010glo.2_5'UTR|C21orf7_uc002yng.2_Missense_Mutation_p.P33S|C21orf7_uc010glp.2_RNA	NM_020152	NP_064537	P57077	TAK1L_HUMAN	chromosome 21 open reading frame 7	133						cytosol|nucleus	protein binding			ovary(2)	2				Colorectal(56;0.248)		AGACTCCATTCCTTTGGTCTT	0.423													138	102					0	0	0	0	T	30521536	T	T	30521536	3	4	10	1	0	0	0	0	1	0	0	0	2142	855	30	2	415	2	C21orf7	21	30521536	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08	14767678	30521536	17608359	148	2692											
BID	637	broad.mit.edu	37	chr22	18222188	18222189	+	Frame_Shift_Ins	INS	-	T	T																															cggagggatgctacggtccaINStgctgtccccgacctgggcg																										TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr22:18222188_18222189insT	uc002znd.1	-	4	459_460	c.289_290insA	c.(289-291)ATGfs	p.M97fs	BID_uc002znc.1_Frame_Shift_Ins_p.M143fs|BID_uc002zne.1_Frame_Shift_Ins_p.M1fs|BID_uc010gra.1_RNA|BID_uc002znf.1_Frame_Shift_Ins_p.M1fs|BID_uc010grb.1_Frame_Shift_Ins_p.M97fs|BID_uc010grc.1_Frame_Shift_Ins_p.M1fs	NM_001196	NP_001187	P55957	BID_HUMAN	BH3 interacting domain death agonist isoform 2	97	BH3.				activation of pro-apoptotic gene products|establishment of protein localization in membrane|induction of apoptosis by intracellular signals|induction of apoptosis via death domain receptors|neuron apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|release of cytochrome c from mitochondria	cytosol|membrane fraction|mitochondrial outer membrane	death receptor binding				0		all_epithelial(15;0.198)		Lung(27;0.0419)		GCTACGGTCCATGCTGTCCCCG	0.629													---	---	---								T	18222189	T	T	18222188	7	5	10	1	0	1	1	0	0	0	0	0	1433	217	8	0	309	0	BID	22	18222188	Frame_Shift_Ins	INS	-	TCGA-BA-5555-01A-01D-1512-08		18222188	33082378	149	2693											
MICAL3	57553	broad.mit.edu	37	chr22	18369952	18369952	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcacctcctctgattgactgGtctttctcctcttcccagca	5	15	5	16	0	5	2	1	2	4	0	8	2	7	2	4	1	1	1	4	1	0	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr22:18369952G>A	uc002zng.3	-	15	2404	c.2051C>T	c.(2050-2052)ACC>ATC	p.T684I	MICAL3_uc011agl.1_Missense_Mutation_p.T684I|MICAL3_uc002znh.2_Missense_Mutation_p.T684I|MICAL3_uc002znj.1_Missense_Mutation_p.T384I|MICAL3_uc002znk.1_Missense_Mutation_p.T684I|MICAL3_uc002znl.1_Missense_Mutation_p.T317I|MICAL3_uc002znm.2_Missense_Mutation_p.T185I|MICAL3_uc010grf.2_Missense_Mutation_p.T684I	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	684						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		TGATTGACTGGTCTTTCTCCT	0.433													19	48					0	0	0	0	A	18369952	A	A	18369952	3	1	10	1	0	0	0	0	1	0	0	0	9624	1261	44	4	4766	4	MICAL3	22	18369952	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	147764	18369952	32934614	150	2694											
TIMP3	7078	broad.mit.edu	37	chr22	33253268	33253268	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcaccaagatgccccatgtGcagtacatccatacggaagc	12	8	8	13	1	1	1	1	0	0	1	2	2	2	2	4	1	5	2	4	1	4	3			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr22:33253268G>C	uc003anb.2	+	3	1423	c.237G>C	c.(235-237)GTG>GTC	p.V79V	SYN3_uc003amx.2_Intron|SYN3_uc003amy.2_Intron|SYN3_uc003amz.2_Intron	NM_000362	NP_000353	P35625	TIMP3_HUMAN	tissue inhibitor of metalloproteinase 3	79	NTR.				negative regulation of membrane protein ectodomain proteolysis|visual perception		metal ion binding|metalloendopeptidase inhibitor activity|protein binding			lung(1)	1						TGCCCCATGTGCAGTACATCC	0.453													62	129					0	0	0	0	C	33253268	C	C	33253268	2	2	10	1	0	0	0	0	0	0	0	1	15985	1306	46	4		4	TIMP3	22	33253268	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	14883316	33253268	18051298	151	2695											
TTLL12	23170	broad.mit.edu	37	chr22	43575707	43575707	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccagggcagcagcatgcacTtccggatcagggggtccgtc	7	6	14	14	2	1	0	1	0	0	0	4	1	3	1	3	4	3	4	3	4	0	1			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr22:43575707T>C	uc003bdq.2	-	5	790	c.758A>G	c.(757-759)AAG>AGG	p.K253R	TTLL12_uc003bdr.1_Missense_Mutation_p.K253R	NM_015140	NP_055955	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	253					protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)	1		Ovarian(80;0.221)|Glioma(61;0.222)				CAGCATGCACTTCCGGATCAG	0.662													52	135					0	0	0	0	C	43575707	C	C	43575707	3	2	10	1	0	0	0	0	1	0	0	0	16793	1609	56	5	1216	5	TTLL12	22	43575707	Missense_Mutation	SNP	T	TCGA-BA-5555-01A-01D-1512-08	10322439	43575707	7728859	152	2696											
MOV10L1	54456	broad.mit.edu	37	chr22	50591608	50591608	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctgggctgggagaagttGcctaagaaaggcttccctct	8	11	13	9	0	1	2	0	0	1	2	2	3	2	2	2	3	2	4	2	3	3	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr22:50591608G>A	uc003bjj.2	+	22	3110	c.3027G>A	c.(3025-3027)TTG>TTA	p.L1009L	MOV10L1_uc003bjk.3_Silent_p.L1009L|MOV10L1_uc011arp.1_Silent_p.L989L|MOV10L1_uc003bjl.2_Silent_p.L136L|MOV10L1_uc003bjm.1_Silent_p.L52L	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	1009					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GGGAGAAGTTGCCTAAGAAAG	0.582													58	166					0	0	0	0	A	50591608	A	A	50591608	2	1	10	1	0	0	0	0	0	0	0	1	9772	1310	46	4		4	MOV10L1	22	50591608	Silent	SNP	G	TCGA-BA-5555-01A-01D-1512-08	7015901	50591608	712958	153	2697											
PLXNB2	23654	broad.mit.edu	37	chr22	50721196	50721196	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggggttttcgcggtaggtGaagaagatgccggggttggg	7	9	20	5	4	0	3	0	1	0	2	1	3	0	3	1	7	1	3	1	7	3	4			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chr22:50721196G>C	uc003bkv.3	-	18	3037	c.2931C>G	c.(2929-2931)TTC>TTG	p.F977L	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	977	Extracellular (Potential).|IPT/TIG 2.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGCGGTAGGTGAAGAAGATGC	0.677													7	34					0	0	0	0	C	50721196	C	C	50721196	3	2	10	1	0	0	0	0	1	0	0	0	12179	1281	45	2	2665	2	PLXNB2	22	50721196	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	129588	50721196	583370	154	2698											
ARHGAP6	395	broad.mit.edu	37	chrX	11204464	11204464	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttttcctttttactttgagCctcagcaggcaaggaaagtt	9	16	8	8	0	1	1	1	1	0	0	2	2	2	2	2	2	3	3	2	2	3	7			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chrX:11204464C>A	uc004cup.1	-	5	2038	c.1165G>T	c.(1165-1167)GCT>TCT	p.A389S	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.A389S|ARHGAP6_uc004cum.1_Missense_Mutation_p.A186S|ARHGAP6_uc004cun.1_Missense_Mutation_p.A209S|ARHGAP6_uc010neb.1_Missense_Mutation_p.A211S|ARHGAP6_uc011mif.1_Missense_Mutation_p.A186S	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	389					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						TTACTTTGAGCCTCAGCAGGC	0.463													163	103					9.35327e-79	1.24061e-78	1	0	A	11204464	A	A	11204464	3	1	10	1	0	0	0	0	1	0	0	0	887	739	26	4	1917	4	ARHGAP6	23	11204464	Missense_Mutation	SNP	C	TCGA-BA-5555-01A-01D-1512-08		11204464	144066096	155	2699											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29972680	29972680	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acttatcatacaccaaagtgGatcctgaccagtggaatcaa	15	9	7	10	0	2	1	2	1	0	0	3	3	3	3	3	2	1	0	3	2	5	2			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chrX:29972680G>T	uc004dby.2	+	10	1751	c.1243G>T	c.(1243-1245)GAT>TAT	p.D415Y		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	415	Cytoplasmic (Potential).|TIR.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						CACCAAAGTGGATCCTGACCA	0.358													48	29					3.68337e-26	4.34274e-26	1	0	T	29972680	T	T	29972680	3	4	10	1	0	0	0	0	1	0	0	0	7700	1174	41	2	1277	2	IL1RAPL1	23	29972680	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	18768216	29972680	125297880	156	2700											
CXorf22	170063	broad.mit.edu	37	chrX	36007603	36007603	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aacatggtttttgttttgagGgctatgaatttgttgggtat	8	19	12	2	0	0	2	0	2	0	0	0	2	0	2	0	3	1	5	0	3	4	8			TCGA-BA-5555-01A-01D-1512-08	TCGA-BA-5555-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	65dc1531-713b-41ba-a567-caa12340c0cf	7c55fb6b-c9eb-4d2c-bd12-52d94e821743	g.chrX:36007603G>T	uc004ddj.2	+	16	2940	c.2881G>T	c.(2881-2883)GGC>TGC	p.G961C	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	961										large_intestine(1)|lung(1)|ovary(1)	3						TTGTTTTGAGGGCTATGAATT	0.328													41	31					1.59932e-28	1.90919e-28	1	0	T	36007603	T	T	36007603	3	4	10	1	0	0	0	0	1	0	0	0	4119	1232	43	4	2943	4	CXorf22	23	36007603	Missense_Mutation	SNP	G	TCGA-BA-5555-01A-01D-1512-08	6034923	36007603	119262957	157	2701											
CNR2	1269	broad.mit.edu	37	chr1	24202069	24202069	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggaatccaagccatccttGgagccattggctatctctgt	8	13	9	11	0	1	0	0	0	1	0	4	2	3	2	4	3	2	1	4	3	3	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:24202069G>C	uc001bif.2	-	2	166	c.39C>G	c.(37-39)TCC>TCG	p.S13S		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	13	Extracellular (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	AGCCATCCTTGGAGCCATTGG	0.512													24	188					0	0	0	0	C	24202069	C	C	24202069	2	2	11	1	0	0	0	0	0	0	0	1	3647	1335	47	4		4	CNR2	1	24202069	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08		24202069	225048552	1	2702											
THRAP3	9967	broad.mit.edu	37	chr1	36755247	36755247	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccccaagaaagacctctGagagccgagacaagctggga	13	4	11	13	1	1	4	0	1	1	4	2	7	2	5	4	1	2	1	4	1	3	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:36755247G>T	uc001cae.3	+	5	1851	c.1627G>T	c.(1627-1629)GAG>TAG	p.E543*	THRAP3_uc001caf.3_Nonsense_Mutation_p.E543*|THRAP3_uc001cag.1_Nonsense_Mutation_p.E543*	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	543					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AAAGACCTCTGAGAGCCGAGA	0.507			T	USP6	aneurysmal bone cysts								24	198					6.12954e-19	7.26735e-19	1	0	T	36755247	T	T	36755247	4	4	11	1	0	0	0	0	0	1	0	0	15940	1291	45	2	1637	2	THRAP3	1	36755247	Nonsense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	12553178	36755247	212495374	2	2703											
PODN	127435	broad.mit.edu	37	chr1	53543413	53543413	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgagctgagcagcctgcgCgagctatacctgcagaacaa	12	5	12	12	3	0	2	0	1	0	1	0	4	0	2	2	0	9	4	2	0	4	2	rs138179023		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:53543413C>T	uc001cuv.2	+	7	946	c.939C>T	c.(937-939)CGC>CGT	p.R313R	PODN_uc001cuw.2_Silent_p.R294R|PODN_uc010onr.1_Silent_p.R294R|PODN_uc010ons.1_Silent_p.R171R	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	265	LRR 8.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						GCAGCCTGCGCGAGCTATACC	0.612													40	183					0	0	0	0	T	53543413	T	T	53543413	2	4	11	1	0	0	0	0	0	0	0	1	12233	755	27	1		1	PODN	1	53543413	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	16788166	53543413	195707208	3	2704											
RTCD1	8634	broad.mit.edu	37	chr1	100736125	100736125	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccttaggagtgtgtgcctCttgatgcaggtctcaatgcc	6	13	11	11	0	2	1	1	1	2	0	4	2	3	2	3	2	3	1	3	2	2	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:100736125C>T	uc001dtc.2	+	4	521	c.303C>T	c.(301-303)CTC>CTT	p.L101L	RTCD1_uc010ouh.1_Silent_p.L101L|RTCD1_uc001dtd.2_Silent_p.L114L	NM_003729	NP_003720	O00442	RTC1_HUMAN	RNA terminal phosphate cyclase domain 1 isoform	101					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0513)|all cancers(265;0.0902)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)		GTGTGTGCCTCTTGATGCAGG	0.398													43	289					0	0	0	0	T	100736125	T	T	100736125	2	4	11	1	0	0	0	0	0	0	0	1	13783	900	32	2		2	RTCD1	1	100736125	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	47192712	100736125	148514496	4	2705											
STXBP3	6814	broad.mit.edu	37	chr1	109342874	109342874	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatagattagattcaaaagaAtggccatattgttcccagtg	15	12	8	6	0	1	3	1	0	0	3	2	3	2	3	2	1	0	1	2	1	7	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:109342874A>G	uc001dvy.2	+	17	1557	c.1482A>G	c.(1480-1482)GAA>GAG	p.E494E	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	494					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		ATTCAAAAGAATGGCCATATT	0.343													15	96					0	0	0	0	G	109342874	G	G	109342874	2	3	11	1	0	0	0	0	0	0	0	1	15420	98	4	5		5	STXBP3	1	109342874	Silent	SNP	A	TCGA-BA-5556-01A-01D-1512-08	8606749	109342874	139907747	5	2706											
APH1A	51107	broad.mit.edu	37	chr1	150240393	150240393	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcaaagcggaacacctccTgtagaaggacagagacagca	16	3	12	10	1	0	2	0	0	0	2	1	5	1	4	2	3	3	3	2	3	4	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:150240393T>C	uc001ety.1	-	2	570	c.248A>G	c.(247-249)CAG>CGG	p.Q83R	APH1A_uc010pbx.1_Splice_Site_p.G38_splice|APH1A_uc001etz.1_Missense_Mutation_p.Q83R|APH1A_uc001eua.1_Missense_Mutation_p.Q83R|APH1A_uc010pby.1_Intron|APH1A_uc001eub.1_Splice_Site|APH1A_uc010pbz.1_Splice_Site	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	83	Helical; Name=3; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAACACCTCCTGTAGAAGGAC	0.552													22	134					0	0	0	0	C	150240393	C	C	150240393	3	2	11	1	0	0	0	0	1	0	0	0	771	1580	55	5	584	5	APH1A	1	150240393	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	40897519	150240393	99010228	6	2707											
USH2A	7399	broad.mit.edu	37	chr1	215972260	215972260	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccccttacctggaaggcgaTtgtacaccactccttcttct	7	12	7	15	1	2	0	0	0	2	0	3	2	3	1	5	2	2	1	5	2	3	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:215972260T>A	uc001hku.1	-	50	10334	c.9947A>T	c.(9946-9948)AAT>ATT	p.N3316I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3316	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGAAGGCGATTGTACACCAC	0.483										HNSCC(13;0.011)			36	128					0	0	0	0	A	215972260	A	A	215972260	3	1	11	1	0	0	0	0	1	0	0	0	17104	1493	52	5	5753	5	USH2A	1	215972260	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	65731867	215972260	33278361	7	2708											
USH2A	7399	broad.mit.edu	37	chr1	216390860	216390860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agtgacaggtttcattcaagGctcctgagagatgacaatta	13	11	10	7	0	2	4	2	3	0	1	3	5	3	4	1	2	0	2	1	2	3	3	rs150729680	byFrequency	TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:216390860G>A	uc001hku.1	-	15	3413	c.3026C>T	c.(3025-3027)GCC>GTC	p.A1009V	USH2A_uc001hkv.2_Missense_Mutation_p.A1009V	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1009	Laminin EGF-like 10.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTCATTCAAGGCTCCTGAGAG	0.393										HNSCC(13;0.011)			9	52					0	0	0	0	A	216390860	A	A	216390860	3	1	11	1	0	0	0	0	1	0	0	0	17104	1203	42	4	12828	4	USH2A	1	216390860	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	418600	216390860	32859761	8	2709											
MARK1	4139	broad.mit.edu	37	chr1	220826574	220826574	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaacagctccgggagcgacGcagcgttgcttataatgggc	9	8	14	10	4	0	1	0	1	0	0	1	3	1	2	1	2	5	4	1	2	3	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:220826574G>C	uc001hmn.3	+	16	2465	c.1868G>C	c.(1867-1869)CGC>CCC	p.R623P	MARK1_uc009xdw.2_Missense_Mutation_p.R624P|MARK1_uc010pun.1_Missense_Mutation_p.R623P|MARK1_uc001hmm.3_Missense_Mutation_p.R601P	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	623					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		CGGGAGCGACGCAGCGTTGCT	0.532													19	127					0	0	0	0	C	220826574	C	C	220826574	3	2	11	1	0	0	0	0	1	0	0	0	9365	1087	38	3	1930	3	MARK1	1	220826574	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	4435714	220826574	28424047	9	2710											
AGT	183	broad.mit.edu	37	chr1	230845931	230845931	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagccaggccctgcacaaaCggctgcttcaggtgcaggcc	9	5	13	14	1	1	1	1	0	0	1	1	1	1	1	3	4	5	4	3	4	1	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:230845931C>T	uc001hty.3	-	2	1174	c.666G>A	c.(664-666)CCG>CCA	p.P222P	AGT_uc009xfe.2_Silent_p.P222P|AGT_uc009xff.2_Silent_p.P194P	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	222					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	CCTGCACAAACGGCTGCTTCA	0.617													5	91					0	0	0	0	T	230845931	T	T	230845931	2	4	11	1	0	0	0	0	0	0	0	1	399	523	19	1		1	AGT	1	230845931	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	10019357	230845931	18404690	10	2711											
GREM2	64388	broad.mit.edu	37	chr1	240656540	240656540	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctcgctcaccgtctgcCgcagcggctgcgtcttgcac	3	9	10	19	5	3	0	1	0	2	0	5	0	4	0	4	1	4	4	4	1	0	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:240656540C>T	uc001hys.2	-	2	516	c.236G>A	c.(235-237)CGG>CAG	p.R79Q		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	79	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			CACCGTCTGCCGCAGCGGCTG	0.642													4	29					0	0	0	0	T	240656540	T	T	240656540	3	4	11	1	0	0	0	0	1	0	0	0	6801	652	23	1	274	1	GREM2	1	240656540	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	9810609	240656540	8594081	11	2712											
SLC4A1AP	22950	broad.mit.edu	37	chr2	27890212	27890212	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggaaagggaggccttttatAtaaaggatcccaaaaaggct	16	8	11	6	0	0	0	0	0	0	0	1	3	1	3	2	5	0	1	2	5	7	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:27890212A>G	uc002rlk.3	+	3	1381	c.1099A>G	c.(1099-1101)ATA>GTA	p.I367V		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	367						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					GGCCTTTTATATAAAGGATCC	0.418													26	123					0	0	0	0	G	27890212	G	G	27890212	3	3	11	1	0	0	0	0	1	0	0	0	14717	449	16	5	1109	5	SLC4A1AP	2	27890212	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08		27890212	215309161	12	2713											
SLC8A1	6546	broad.mit.edu	37	chr2	40656013	40656013	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgatttccttctgggtatCaccaggcttaaacaccacag	10	12	7	12	0	3	1	1	1	2	0	4	1	4	1	3	2	1	2	3	2	3	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:40656013C>T	uc002rrx.2	-	1	1432	c.1408G>A	c.(1408-1410)GAT>AAT	p.D470N	SLC8A1_uc002rry.2_Missense_Mutation_p.D470N|SLC8A1_uc002rrz.2_Missense_Mutation_p.D470N|SLC8A1_uc002rsa.2_Missense_Mutation_p.D470N|SLC8A1_uc002rsd.3_Missense_Mutation_p.D470N|SLC8A1_uc002rsb.1_Missense_Mutation_p.D470N|SLC8A1_uc010fan.1_Missense_Mutation_p.D470N|SLC8A1_uc002rsc.1_Missense_Mutation_p.D470N	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	470	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TTCTGGGTATCACCAGGCTTA	0.408													12	106					0	0	0	0	T	40656013	T	T	40656013	3	4	11	1	0	0	0	0	1	0	0	0	14770	826	29	2	1661	2	SLC8A1	2	40656013	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	12765801	40656013	202543360	13	2714											
TUBA3D	113457	broad.mit.edu	37	chr2	132240222	132240222	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagcaacaccacggccattgCggaggcctgggcccgcctgg	7	4	15	15	3	0	0	0	0	0	0	0	2	0	1	5	5	3	1	5	5	1	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:132240222C>T	uc002tsu.3	+	5	1261	c.1154C>T	c.(1153-1155)GCG>GTG	p.A385V		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	385					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		ACGGCCATTGCGGAGGCCTGG	0.632													18	116					0	0	0	0	T	132240222	T	T	132240222	3	4	11	1	0	0	0	0	1	0	0	0	16815	768	27	1	1172	1	TUBA3D	2	132240222	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	91584209	132240222	110959151	14	2715											
LRP1B	53353	broad.mit.edu	37	chr2	141027862	141027862	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctggcatgtgccaccattgTaacagtagccatcacataac	12	9	8	12	0	1	0	1	0	0	0	1	0	1	0	3	1	4	4	3	1	3	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:141027862T>C	uc002tvj.1	-	86	14168	c.13196A>G	c.(13195-13197)TAC>TGC	p.Y4399C		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4399	Extracellular (Potential).|EGF-like 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCCACCATTGTAACAGTAGCC	0.403										TSP Lung(27;0.18)			12	132					0	0	0	0	C	141027862	C	C	141027862	3	2	11	1	0	0	0	0	1	0	0	0	9005	1638	57	5	627	5	LRP1B	2	141027862	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	8787640	141027862	102171511	15	2716											
LRP1B	53353	broad.mit.edu	37	chr2	141571360	141571360	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aataaagcttgttttccacaTagtctatcgatagacctgta	13	14	6	8	1	1	1	0	0	1	1	3	2	2	1	2	0	1	3	2	0	7	8			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:141571360T>A	uc002tvj.1	-	32	6197	c.5225A>T	c.(5224-5226)TAT>TTT	p.Y1742F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1742	Extracellular (Potential).|LDL-receptor class B 16.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTTTTCCACATAGTCTATCGA	0.348										TSP Lung(27;0.18)			13	109					0	0	0	0	A	141571360	A	A	141571360	3	1	11	1	0	0	0	0	1	0	0	0	9005	1406	49	5	8814	5	LRP1B	2	141571360	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	543498	141571360	101628013	16	2717											
ZC3H15	55854	broad.mit.edu	37	chr2	187364950	187364950	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaattgaagaaggatgaCaagaagaaagaattgcagga	22	5	12	2	0	0	7	0	2	0	5	0	9	0	9	0	2	1	1	0	2	8	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:187364950C>G	uc002upo.2	+	3	444	c.219C>G	c.(217-219)GAC>GAG	p.D73E		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	73	Potential.					cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			AGAAGGATGACAAGAAGAAAG	0.308													6	51					0	0	0	0	G	187364950	G	G	187364950	3	3	11	1	0	0	0	0	1	0	0	0	17634	477	17	4	229	4	ZC3H15	2	187364950	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	45793590	187364950	55834423	17	2718											
CASP8	841	broad.mit.edu	37	chr2	202149860	202149860	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatacctgttgagactgattCagaggagcaaccctatttag	12	12	9	8	0	1	3	1	2	0	2	1	5	1	4	2	1	3	2	2	1	5	7			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:202149860C>G	uc002uxr.1	+	9	1333	c.1124C>G	c.(1123-1125)TCA>TGA	p.S375*	CASP8_uc002uxp.1_Nonsense_Mutation_p.S392*|CASP8_uc002uxq.1_Nonsense_Mutation_p.S360*|CASP8_uc002uxt.1_Nonsense_Mutation_p.S434*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.S360*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.S291*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	375					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GAGACTGATTCAGAGGAGCAA	0.448										HNSCC(4;0.00038)			25	112					0	0	0	0	G	202149860	G	G	202149860	4	3	11	1	0	0	0	0	0	1	0	0	2689	838	29	2	1431	2	CASP8	2	202149860	Nonsense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	14784910	202149860	41049513	18	2719											
C2orf24	27013	broad.mit.edu	37	chr2	220037648	220037648	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccatgctgccttccaggCagctggagacattagcgaga	9	7	12	13	1	0	2	0	0	0	2	1	4	1	2	4	2	4	3	4	2	1	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:220037648C>A	uc002vju.3	-	8	1045	c.893G>T	c.(892-894)TGC>TTC	p.C298F	NHEJ1_uc002vjq.3_5'Flank|SLC23A3_uc010zkr.1_5'Flank|SLC23A3_uc010zks.1_5'Flank|SLC23A3_uc010fwb.2_5'Flank|C2orf24_uc002vjv.2_Missense_Mutation_p.C298F	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	298					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCTTCCAGGCAGCTGGAGAC	0.647													17	127					2.39187e-15	2.80231e-15	1	0	A	220037648	A	A	220037648	3	1	11	1	0	0	0	0	1	0	0	0	2169	710	25	4	343	4	C2orf24	2	220037648	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	17887788	220037648	23161725	19	2720											
GRM7	2917	broad.mit.edu	37	chr3	7348199	7348199	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccacaggcagatccttgcagCagccaaaagagctgaccaag	14	4	10	13	0	0	3	0	1	0	2	1	3	1	3	4	1	4	4	4	1	3	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:7348199C>A	uc003bqm.2	+	4	1167	c.893C>A	c.(892-894)GCA>GAA	p.A298E	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.A298E|GRM7_uc003bql.2_Missense_Mutation_p.A298E|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	298	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	ATCCTTGCAGCAGCCAAAAGA	0.438													6	198					0.00198382	0.00207829	1	0	A	7348199	A	A	7348199	3	1	11	1	0	0	0	0	1	0	0	0	6841	710	25	4	907	4	GRM7	3	7348199	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08		7348199	190674231	20	2721											
ITGA9	3680	broad.mit.edu	37	chr3	37555268	37555268	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgcagatgggctcttacttCggctcctccttgtgcgcagt	4	14	11	12	2	1	1	0	0	1	1	4	1	3	1	2	2	3	4	2	2	1	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:37555268C>T	uc003chd.2	+	9	965	c.912C>T	c.(910-912)TTC>TTT	p.F304F	ITGA9_uc003chc.2_Silent_p.F304F	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	304	Extracellular (Potential).|FG-GAP 5.				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		GCTCTTACTTCGGCTCCTCCT	0.552													15	82					0	0	0	0	T	37555268	T	T	37555268	2	4	11	1	0	0	0	0	0	0	0	1	7922	883	31	1		1	ITGA9	3	37555268	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	30207069	37555268	160467162	21	2722											
RBM6	10180	broad.mit.edu	37	chr3	50095359	50095359	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtatctgcctccttctcgaaGggaagggccaactttccgaa	9	10	10	12	2	2	0	0	0	2	0	5	3	4	1	4	2	2	1	4	2	5	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:50095359G>A	uc003cyc.2	+	9	2025	c.1892G>A	c.(1891-1893)AGG>AAG	p.R631K	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_Missense_Mutation_p.R150K|RBM6_uc003cyd.2_Missense_Mutation_p.R109K|RBM6_uc003cye.2_Missense_Mutation_p.R109K|RBM6_uc011bdi.1_5'UTR|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	631					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		CCTTCTCGAAGGGAAGGGCCA	0.512													10	61					0	0	0	0	A	50095359	A	A	50095359	3	1	11	1	0	0	0	0	1	0	0	0	13209	1000	35	4	1922	4	RBM6	3	50095359	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	12540091	50095359	147927071	22	2723											
BAP1	8314	broad.mit.edu	37	chr3	52441440	52441440	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atggctattatgggccttggCcaactccggggcattgccaa	8	10	12	11	1	0	0	0	0	0	0	1	0	1	0	4	5	2	2	4	5	4	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:52441440C>T	uc003ddx.2	-	6	527	c.412G>A	c.(412-414)GCC>ACC	p.A138T	BAP1_uc010hmh.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	138					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.?(2)		pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		TGGGCCTTGGCCAACTCCGGG	0.517			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								5	162					0	0	0	0	T	52441440	T	T	52441440	3	4	11	1	0	0	0	0	1	0	0	0	1313	739	26	4	1825	4	BAP1	3	52441440	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	2346081	52441440	145580990	23	2724											
C3orf63	23272	broad.mit.edu	37	chr3	56681252	56681252	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attggttgaacctttttgtgCtgtaaataaaacaaacaaac	16	13	6	6	0	0	1	0	1	0	0	0	1	0	1	1	1	5	3	1	1	7	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:56681252C>A	uc003did.3	-	14	1615	c.1514_splice	c.e14-1	p.S505_splice	C3orf63_uc003dic.3_Splice_Site_p.S109_splice|C3orf63_uc003die.3_Splice_Site_p.S505_splice	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b											ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		CCTTTTTGTGCTGTAAATAAA	0.318													17	88					2.94398e-08	3.29327e-08	1	0	A	56681252	A	A	56681252	5	1	11	1	0	0	0	0	0	0	1	0	2249	811	28	4	3603	4	C3orf63	3	56681252	Splice_Site	SNP	C	TCGA-BA-5556-01A-01D-1512-08	4239812	56681252	141341178	24	2725											
PLS1	5357	broad.mit.edu	37	chr3	142388320	142388320	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctggctacaaggtgcgCgagattgtggagaaaattct	10	10	13	8	2	1	2	0	0	1	2	1	4	1	2	1	3	3	1	1	3	4	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:142388320C>T	uc010huv.2	+	3	318	c.159C>T	c.(157-159)CGC>CGT	p.R53R	PLS1_uc003euz.2_Silent_p.R53R|PLS1_uc003eva.2_Silent_p.R53R	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	53	EF-hand 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						ACAAGGTGCGCGAGATTGTGG	0.408													26	184					0	0	0	0	T	142388320	T	T	142388320	2	4	11	1	0	0	0	0	0	0	0	1	12162	755	27	1		1	PLS1	3	142388320	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	85707068	142388320	55634110	25	2726											
ZIC4	84107	broad.mit.edu	37	chr3	147114229	147114229	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctggaggcggcggtgagcTgggggccatggtgtccagag	5	6	22	8	2	0	2	0	1	0	1	1	3	1	3	2	8	1	2	2	8	0	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:147114229T>G	uc003ewd.1	-	3	371	c.98A>C	c.(97-99)CAG>CCG	p.Q33P	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Missense_Mutation_p.Q83P	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	33						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GGCGGTGAGCTGGGGGCCATG	0.692													9	37					0	0	0	0	G	147114229	G	G	147114229	3	3	11	1	0	0	0	0	1	0	0	0	17748	1580	55	5	918	5	ZIC4	3	147114229	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	4725909	147114229	50908201	26	2727											
PTX3	5806	broad.mit.edu	37	chr3	157160520	157160520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgttgagatggccacaggtCacattgttcctgagggagga	9	10	14	8	0	1	2	1	2	0	1	2	5	2	4	2	4	0	2	2	4	0	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:157160520C>T	uc003fbl.3	+	3	1041	c.898C>T	c.(898-900)CAC>TAC	p.H300Y	VEPH1_uc003fbj.1_Intron|VEPH1_uc003fbk.1_Intron|VEPH1_uc010hvu.1_Intron	NM_002852	NP_002843	P26022	PTX3_HUMAN	pentraxin 3 precursor	300	Pentaxin.				inflammatory response	extracellular region				central_nervous_system(1)	1			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			GGCCACAGGTCACATTGTTCC	0.532													9	83					0	0	0	0	T	157160520	T	T	157160520	3	4	11	1	0	0	0	0	1	0	0	0	12887	826	29	2	908	2	PTX3	3	157160520	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	10046291	157160520	40861910	27	2728											
SLITRK3	22865	broad.mit.edu	37	chr3	164908254	164908254	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctttaaaatcttaagaccaTtgaaagctccagtctgaatg	14	13	6	8	0	3	3	0	2	3	1	4	3	4	3	2	0	1	1	2	0	5	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:164908254T>C	uc003fej.3	-	2	809	c.365A>G	c.(364-366)AAT>AGT	p.N122S	SLITRK3_uc003fek.2_Missense_Mutation_p.N122S	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	122	LRR 2.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CTTAAGACCATTGAAAGCTCC	0.348										HNSCC(40;0.11)			22	106					0	0	0	0	C	164908254	C	C	164908254	3	2	11	1	0	0	0	0	1	0	0	0	14808	1493	52	5	2572	5	SLITRK3	3	164908254	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	7747734	164908254	33114176	28	2729											
PPAT	5471	broad.mit.edu	37	chr4	57267496	57267496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaaagaaatctacttacCttcgaacatactgtctggtc	15	11	6	9	1	2	2	0	0	2	2	4	3	2	2	1	1	4	0	1	1	8	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:57267496C>T	uc003hbr.2	-	7	1088	c.886G>A	c.(886-888)GAC>AAC	p.D296N		NM_002703	NP_002694	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	296					glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	ATCTACTTACCTTCGAACATA	0.353													19	271					0	0	0	0	T	57267496	T	T	57267496	3	4	11	1	0	0	0	0	1	0	0	0	12357	695	24	4	687	4	PPAT	4	57267496	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08		57267496	133886780	29	2730											
YTHDC1	91746	broad.mit.edu	37	chr4	69184292	69184292	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaattccctcacataatcaTtgtaggactaaaataaaaga	19	10	5	7	0	2	1	2	0	0	1	3	3	3	2	1	1	0	1	1	1	7	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:69184292T>C	uc003hdx.2	-	15	2122	c.1769A>G	c.(1768-1770)AAT>AGT	p.N590S	YTHDC1_uc003hdy.2_Missense_Mutation_p.N572S	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	590										upper_aerodigestive_tract(1)|ovary(1)	2						CACATAATCATTGTAGGACTA	0.289													7	64					0	0	0	0	C	69184292	C	C	69184292	3	2	11	1	0	0	0	0	1	0	0	0	17564	1493	52	5	426	5	YTHDC1	4	69184292	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	11916796	69184292	121969984	30	2731											
FRAS1	80144	broad.mit.edu	37	chr4	79285132	79285132	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcctcatgtgacaccaacctCgtgctgtcccacactggcac	8	9	7	17	1	1	1	1	1	0	0	4	1	3	1	4	1	2	2	4	1	1	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:79285132C>T	uc003hlb.2	+	22	3086	c.2646C>T	c.(2644-2646)CTC>CTT	p.L882L	FRAS1_uc003hkw.2_Silent_p.L882L	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	882	FU 10.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ACACCAACCTCGTGCTGTCCC	0.527													3	24					0	0	0	0	T	79285132	T	T	79285132	2	4	11	1	0	0	0	0	0	0	0	1	6076	871	31	1		1	FRAS1	4	79285132	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	10100840	79285132	111869144	31	2732											
HERC3	8916	broad.mit.edu	37	chr4	89591032	89591032	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taactggtggtctcaggtatGcccgaaatatttcatgaagc	11	12	10	8	1	2	1	2	1	1	0	3	2	2	1	1	3	3	1	1	3	5	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:89591032G>A	uc003hrw.1	+	15	1821	c.1655G>A	c.(1654-1656)TGC>TAC	p.C552Y	HERC3_uc011cdn.1_Missense_Mutation_p.C434Y|HERC3_uc011cdo.1_5'UTR	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	552					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TCTCAGGTATGCCCGAAATAT	0.363													20	137					0	0	0	0	A	89591032	A	A	89591032	3	1	11	1	0	0	0	0	1	0	0	0	7098	1319	46	4	1705	4	HERC3	4	89591032	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	10305900	89591032	101563244	32	2733											
PAPSS1	9061	broad.mit.edu	37	chr4	108608212	108608212	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctttaatttctcctgccCgggcttttttgtagagtcct	5	17	8	11	1	1	1	0	0	1	1	3	2	2	1	4	1	1	2	4	1	2	7			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:108608212C>T	uc003hyk.2	-	4	617	c.533G>A	c.(532-534)CGG>CAG	p.R178Q	PAPSS1_uc011cfh.1_Intron	NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	178	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		TTCTCCTGCCCGGGCTTTTTT	0.363													11	238					0	0	0	0	T	108608212	T	T	108608212	3	4	11	1	0	0	0	0	1	0	0	0	11488	652	23	1	1377	1	PAPSS1	4	108608212	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	19017180	108608212	82546064	33	2734											
MORF4	10934	broad.mit.edu	37	chr4	174537544	174537545	+	Missense_Mutation	DNP	CA	GC	GC																															tttgcctggtaattaagtccCagtcatcaacaagccatggt																										TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:174537544_174537545CA>GC	uc011cke.1	-	1	250_251	c.250_251TG>GC	c.(250-252)TGG>GCG	p.W84A		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		AATTAAGTCCCAGTCATCAACA	0.391													31	253					0	0	0	0	GC	174537545	GC	GC	174537544	3	3	11	1	0	0	0	0	1	0	0	0	9758	595	21	4	459	4	MORF4	4	174537544	Missense_Mutation	DNP	CA	TCGA-BA-5556-01A-01D-1512-08	65929332	174537544	16616732	34	2735											
HEATR7B2	133558	broad.mit.edu	37	chr5	41018010	41018010	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcctgacggatggtgggcagGgtatcacaggagtgaggagc	9	6	19	7	1	1	2	1	2	0	0	1	5	1	5	1	6	1	2	1	6	1	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr5:41018010G>A	uc003jmj.3	-	28	3316	c.2826C>T	c.(2824-2826)ACC>ACT	p.T942T	HEATR7B2_uc003jmi.3_Silent_p.T497T	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	942							binding			ovary(6)|central_nervous_system(2)	8						TGGTGGGCAGGGTATCACAGG	0.483													7	12					0	0	0	0	A	41018010	A	A	41018010	2	1	11	1	0	0	0	0	0	0	0	1	7074	1219	43	4		4	HEATR7B2	5	41018010	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08		41018010	139897250	35	2736											
PPIP5K2	23262	broad.mit.edu	37	chr5	102487035	102487035	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaatggcttcagttttgtgAaaaattccatgaagtattat	13	16	7	5	0	2	2	2	2	0	0	3	2	3	2	1	1	0	3	1	1	6	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr5:102487035A>T	uc003kod.3	+	9	1504	c.985A>T	c.(985-987)AAA>TAA	p.K329*	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Nonsense_Mutation_p.K329*|PPIP5K2_uc010jbo.1_Nonsense_Mutation_p.K251*	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	329					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						CAGTTTTGTGAAAAATTCCAT	0.308													31	131					0	0	0	0	T	102487035	T	T	102487035	4	4	11	1	0	0	0	0	0	1	0	0	12393	247	9	5	1015	5	PPIP5K2	5	102487035	Nonsense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	61469025	102487035	78428225	36	2737											
C5orf15	56951	broad.mit.edu	37	chr5	133295208	133295208	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttttgttgtgatatgtaaTgtaaacaacagcaatgcaaa	15	13	7	6	0	0	1	0	1	0	0	0	1	0	1	1	0	4	5	1	0	7	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr5:133295208T>C	uc003kyo.2	-	2	774	c.643A>G	c.(643-645)ATT>GTT	p.I215V		NM_020199	NP_064584	Q8NC54	KCT2_HUMAN	keratinocytes associated transmembrane protein 2	215	Helical; (Potential).					integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)			TGATATGTAATGTAAACAACA	0.289													12	68					0	0	0	0	C	133295208	C	C	133295208	3	2	11	1	0	0	0	0	1	0	0	0	2293	1464	51	5	162	5	C5orf15	5	133295208	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	30808173	133295208	47620052	37	2738											
HARS2	23438	broad.mit.edu	37	chr5	140073602	140073602	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagctgctttaaacgtcatgGagcaaaggggatggacaccc	12	7	12	10	1	1	0	1	0	0	0	1	3	1	3	1	4	4	3	1	4	3	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr5:140073602G>A	uc003lgx.2	+	3	482	c.266G>A	c.(265-267)GGA>GAA	p.G89E	HARS_uc003lgv.2_5'Flank|HARS_uc011czm.1_5'Flank|HARS_uc003lgw.2_5'Flank|HARS_uc011czn.1_5'Flank|HARS_uc010jfu.2_5'Flank|HARS_uc011czo.1_5'Flank|HARS_uc011czp.1_5'Flank|HARS_uc011czq.1_5'Flank|HARS2_uc010jfv.1_Missense_Mutation_p.G19E|HARS2_uc011czr.1_Missense_Mutation_p.G64E|HARS2_uc011czs.1_Missense_Mutation_p.G19E|HARS2_uc011czt.1_Intron|HARS2_uc011czu.1_5'Flank	NM_012208	NP_036340	P49590	SYHM_HUMAN	histidyl-tRNA synthetase 2 precursor	89					histidyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|histidine-tRNA ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAACGTCATGGAGCAAAGGGG	0.478													59	245					0	0	0	0	A	140073602	A	A	140073602	3	1	11	1	0	0	0	0	1	0	0	0	6999	1174	41	2	276	2	HARS2	5	140073602	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	6778394	140073602	40841658	38	2739											
PCDHGB7	56099	broad.mit.edu	37	chr5	140798230	140798230	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgagagtgaaggccactgaCcaggacgagggcatcaactc	12	5	13	11	1	1	3	1	3	0	1	2	6	1	4	2	3	1	1	2	3	2	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr5:140798230C>A	uc003lkn.1	+	1	949	c.804C>A	c.(802-804)GAC>GAA	p.D268E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.D268E|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	268	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCCACTGACCAGGACGAGG	0.532													13	68					0.000151284	0.000160184	1	0	A	140798230	A	A	140798230	3	1	11	1	0	0	0	0	1	0	0	0	11622	506	18	4	806	4	PCDHGB7	5	140798230	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	724628	140798230	40117030	39	2740											
CRISP2	7180	broad.mit.edu	37	chr6	49667570	49667570	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgcacttgtttgcccacCtttgggcattcgttgttacc	6	15	9	11	1	0	0	0	0	0	0	1	0	0	0	3	1	3	5	3	1	2	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr6:49667570C>G	uc003ozq.2	-	6	474	c.218G>C	c.(217-219)AGG>ACG	p.R73T	CRISP2_uc003ozl.2_Missense_Mutation_p.R73T|CRISP2_uc003ozn.2_Missense_Mutation_p.R73T|CRISP2_uc003ozr.2_Missense_Mutation_p.R73T|CRISP2_uc003ozo.2_Missense_Mutation_p.R73T|CRISP2_uc003ozm.2_Missense_Mutation_p.R73T|CRISP2_uc003ozp.2_Missense_Mutation_p.R73T	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	73						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GTTTGCCCACCTTTGGGCATT	0.259													12	78					0	0	0	0	G	49667570	G	G	49667570	3	3	11	1	0	0	0	0	1	0	0	0	3895	681	24	4	533	4	CRISP2	6	49667570	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08		49667570	121447497	40	2741											
MICAL1	64780	broad.mit.edu	37	chr6	109766112	109766112	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccttacgtgatcatgagctCggcctcctcagccaccaggc	7	8	9	17	2	2	2	2	2	0	0	4	2	3	2	5	2	3	1	5	2	1	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr6:109766112C>T	uc003ptj.2	-	22	3222	c.2968G>A	c.(2968-2970)GAG>AAG	p.E990K	MICAL1_uc003ptk.2_Missense_Mutation_p.E990K|MICAL1_uc010kdr.2_Missense_Mutation_p.E904K|MICAL1_uc011eaq.1_Missense_Mutation_p.E1009K	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	990					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		ATCATGAGCTCGGCCTCCTCA	0.552													5	242					0	0	0	0	T	109766112	T	T	109766112	3	4	11	1	0	0	0	0	1	0	0	0	9622	893	31	1	247	1	MICAL1	6	109766112	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	60098542	109766112	61348955	41	2742											
SOD2	6648	broad.mit.edu	37	chr6	160106063	160106063	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttgatggcttccagcaactCccctattaaaaaaaaaatcc	15	11	4	11	0	0	1	0	1	0	0	3	1	3	1	4	1	2	2	4	1	7	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr6:160106063C>T	uc003qsg.2	-	4	500	c.346G>A	c.(346-348)GAG>AAG	p.E116K	SOD2_uc003qsh.2_Missense_Mutation_p.E77K|SOD2_uc003qsi.1_Missense_Mutation_p.E116K|SOD2_uc011efu.1_Intron|SOD2_uc011efv.1_Missense_Mutation_p.E77K	NM_001024465	NP_001019636	P04179	SODM_HUMAN	manganese superoxide dismutase isoform A	116					age-dependent response to reactive oxygen species|negative regulation of neuron apoptosis|oxygen homeostasis|protein homotetramerization|regulation of transcription from RNA polymerase II promoter|release of cytochrome c from mitochondria|removal of superoxide radicals|vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure		manganese ion binding|superoxide dismutase activity				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.103)		OV - Ovarian serous cystadenocarcinoma(65;1.4e-18)|BRCA - Breast invasive adenocarcinoma(81;5.77e-06)		TCCAGCAACTCCCCTATTAAA	0.373													7	49					0	0	0	0	T	160106063	T	T	160106063	3	4	11	1	0	0	0	0	1	0	0	0	14985	864	30	2	330	2	SOD2	6	160106063	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	50339951	160106063	11009004	42	2743											
EIF3B	8662	broad.mit.edu	37	chr7	2409152	2409153	+	Missense_Mutation	DNP	GC	TT	TT																															aacataatcgccttctgggtGcctgaagacaaagatattcc																										TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:2409152_2409153GC>TT	uc003slx.2	+	10	1532_1533	c.1449_1450GC>TT	c.(1447-1452)GTGCCT>GTTTCT	p.P484S	EIF3B_uc003sly.2_Missense_Mutation_p.P484S|EIF3B_uc003sma.2_Missense_Mutation_p.P212S	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	484					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CCTTCTGGGTGCCTGAAGACAA	0.47													48	338					0	0	0	0	TT	2409153	TT	TT	2409152	3	4	11	1	0	0	0	0	1	0	0	0	5035	1306	46	4	1487	4	EIF3B	7	2409152	Missense_Mutation	DNP	GC	TCGA-BA-5556-01A-01D-1512-08		2409152	156729511	43	2744											
SEMA3A	10371	broad.mit.edu	37	chr7	83606507	83606507	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttatatcttgtcgtcttGtgcgtctgaagcaattacat	8	18	7	8	2	4	1	0	1	4	0	5	1	4	1	0	0	3	1	0	0	5	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:83606507G>A	uc003uhz.2	-	15	1973	c.1658C>T	c.(1657-1659)ACA>ATA	p.T553I		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	553					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TTGTCGTCTTGTGCGTCTGAA	0.343													18	120					0	0	0	0	A	83606507	A	A	83606507	3	1	11	1	0	0	0	0	1	0	0	0	14089	1377	48	4	669	4	SEMA3A	7	83606507	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	81197355	83606507	75532156	44	2745											
MUC17	140453	broad.mit.edu	37	chr7	100679879	100679879	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccacttctactgaagccCgttcatctcctacaacttct	9	13	4	15	1	4	2	1	2	3	0	5	2	4	2	3	0	4	1	3	0	4	5	rs71273404		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:100679879C>T	uc003uxp.1	+	3	5235	c.5182C>T	c.(5182-5184)CGT>TGT	p.R1728C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1728	Extracellular (Potential).|59 X approximate tandem repeats.|27.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACTGAAGCCCGTTCATCTCC	0.498													58	353					0	0	0	0	T	100679879	T	T	100679879	3	4	11	1	0	0	0	0	1	0	0	0	10027	652	23	1	5192	1	MUC17	7	100679879	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	17073372	100679879	58458784	45	2746											
MUC17	140453	broad.mit.edu	37	chr7	100683048	100683048	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccagcatacctgtcaccaCttctactgaagccagttcct	10	10	5	16	0	2	1	1	1	1	0	3	1	3	1	5	0	4	2	5	0	3	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:100683048C>A	uc003uxp.1	+	3	8404	c.8351C>A	c.(8350-8352)ACT>AAT	p.T2784N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2784	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|45.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTGTCACCACTTCTACTGAA	0.478													9	340					2.17888e-05	2.33199e-05	1	0	A	100683048	A	A	100683048	3	1	11	1	0	0	0	0	1	0	0	0	10027	565	20	4	8361	4	MUC17	7	100683048	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	3169	100683048	58455615	46	2747											
MUC17	140453	broad.mit.edu	37	chr7	100686329	100686329	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaagaagcactccattaacaActctccttgtcagcaccaca	15	8	4	14	0	2	1	1	0	1	1	4	1	3	1	3	0	4	2	3	0	4	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:100686329A>G	uc003uxp.1	+	3	11685	c.11632A>G	c.(11632-11634)ACT>GCT	p.T3878A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3878	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCATTAACAACTCTCCTTGT	0.468													38	185					0	0	0	0	G	100686329	G	G	100686329	3	3	11	1	0	0	0	0	1	0	0	0	10027	43	2	5	11642	5	MUC17	7	100686329	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	3281	100686329	58452334	47	2748											
MOGAT3	346606	broad.mit.edu	37	chr7	100843751	100843751	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaacagagaagggccagAgtgacgtgaagaggaggaca	19	2	15	5	1	0	5	0	2	0	3	0	8	0	7	1	3	1	0	1	3	5	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:100843751A>T	uc003uyc.2	-	2	322	c.155T>A	c.(154-156)CTC>CAC	p.L52H	MOGAT3_uc010lhr.2_Missense_Mutation_p.L52H	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	52	Helical; (Potential).				glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					GAAGGGCCAGAGTGACGTGAA	0.527													7	27					0	0	0	0	T	100843751	T	T	100843751	3	4	11	1	0	0	0	0	1	0	0	0	9749	304	11	5	894	5	MOGAT3	7	100843751	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	157422	100843751	58294912	48	2749											
LRRN3	54674	broad.mit.edu	37	chr7	110762919	110762919	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaaaaagtggattgtccaCggttatgtacgtgtgaaatc	14	12	10	5	2	0	1	0	1	0	0	2	2	1	2	1	2	1	2	1	2	6	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:110762919C>A	uc003vft.3	+	4	1137	c.91C>A	c.(91-93)CGG>AGG	p.R31R	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Silent_p.R31R|LRRN3_uc003vfs.3_Silent_p.R31R	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	31	Extracellular (Potential).|LRRNT.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		GGATTGTCCACGGTTATGTAC	0.408													21	148					2.37509e-13	2.73412e-13	1	0	A	110762919	A	A	110762919	2	1	11	1	0	0	0	0	0	0	0	1	9086	527	19	3		3	LRRN3	7	110762919	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	9919168	110762919	48375744	49	2750											
NRF1	4899	broad.mit.edu	37	chr7	129297354	129297354	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaggacacctcttacgatGactcagatatactcaactcc	12	9	6	14	2	3	2	2	1	1	1	4	5	4	3	3	1	3	0	3	1	4	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:129297354G>T	uc003voz.2	+	2	280	c.163G>T	c.(163-165)GAC>TAC	p.D55Y	NRF1_uc003vpa.2_Missense_Mutation_p.D55Y|NRF1_uc011kpa.1_5'UTR|NRF1_uc003vpb.2_Missense_Mutation_p.D55Y	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	55	Dimerization.|Asp/Glu-rich (acidic).				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						CTCTTACGATGACTCAGATAT	0.478													9	124					4.68919e-08	5.21606e-08	1	0	T	129297354	T	T	129297354	3	4	11	1	0	0	0	0	1	0	0	0	10700	1290	45	2	165	2	NRF1	7	129297354	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	18534435	129297354	29841309	50	2751											
ST18	9705	broad.mit.edu	37	chr8	53055550	53055550	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtttagggcttggtatagagGcctctccaggaaactttttt	8	15	11	7	0	1	1	0	0	1	1	2	2	1	2	2	4	1	3	2	4	4	8			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:53055550G>A	uc003xqz.2	-	12	2264	c.2108C>T	c.(2107-2109)GCC>GTC	p.A703V	ST18_uc011ldq.1_Missense_Mutation_p.A350V|ST18_uc011ldr.1_Missense_Mutation_p.A668V|ST18_uc011lds.1_Missense_Mutation_p.A608V|ST18_uc003xra.2_Missense_Mutation_p.A703V	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	703						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGGTATAGAGGCCTCTCCAGG	0.418													25	193					0	0	0	0	A	53055550	A	A	53055550	3	1	11	1	0	0	0	0	1	0	0	0	15278	1203	42	4	1075	4	ST18	8	53055550	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08		53055550	93308472	51	2752											
ATP6V1H	51606	broad.mit.edu	37	chr8	54730074	54730074	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catagtcaaagaaaatgctaAcacgctgatgattttcctaa	16	11	6	8	1	1	3	1	2	0	1	2	3	2	3	1	0	2	2	1	0	6	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:54730074A>G	uc003xrl.2	-	5	475	c.323T>C	c.(322-324)GTT>GCT	p.V108A	ATP6V1H_uc003xrk.2_Missense_Mutation_p.V68A|ATP6V1H_uc003xrm.2_Missense_Mutation_p.V108A|ATP6V1H_uc003xrn.2_Missense_Mutation_p.V108A|ATP6V1H_uc011ldv.1_Missense_Mutation_p.V28A|ATP6V1H_uc010lyd.2_Missense_Mutation_p.V44A	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	108					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			GAAAATGCTAACACGCTGATG	0.413													13	51					0	0	0	0	G	54730074	G	G	54730074	3	3	11	1	0	0	0	0	1	0	0	0	1191	43	2	5	1168	5	ATP6V1H	8	54730074	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	1674524	54730074	91633948	52	2753											
RALYL	138046	broad.mit.edu	37	chr8	85774590	85774590	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtaattccgctgaagcGtcccagagtggcagtcacaa	11	8	11	11	2	1	2	1	1	0	1	3	2	3	2	2	1	2	4	2	1	3	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:85774590G>A	uc003ycq.3	+	7	889	c.473G>A	c.(472-474)CGT>CAT	p.R158H	RALYL_uc003ycr.3_Missense_Mutation_p.R158H|RALYL_uc003ycs.3_Missense_Mutation_p.R158H|RALYL_uc010lzy.2_Missense_Mutation_p.R147H|RALYL_uc003yct.3_Missense_Mutation_p.R171H|RALYL_uc003ycu.3_Missense_Mutation_p.R85H|RALYL_uc003ycv.3_Missense_Mutation_p.R70H	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	158							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						CCGCTGAAGCGTCCCAGAGTG	0.507													7	38					0	0	0	0	A	85774590	A	A	85774590	3	1	11	1	0	0	0	0	1	0	0	0	13085	1145	40	1	534	1	RALYL	8	85774590	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	31044516	85774590	60589432	53	2754											
WWP1	11059	broad.mit.edu	37	chr8	87470164	87470165	+	Frame_Shift_Ins	INS	-	A	A																															cccaggttatgttgtgtggcINSatgcaggaggttgacttggc																										TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:87470164_87470165insA	uc003ydt.2	+	22	2689_2690	c.2409_2410insA	c.(2407-2412)GGCATGfs	p.G803fs		NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	803_804	HECT.			M->P: Strongly reduces ubiquitin transfer; when associated with P-806.	central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						TGTTGTGTGGCATGCAGGAGGT	0.376													---	---	---								A	87470165	A	A	87470164	7	5	11	1	0	1	1	0	0	0	0	0	17483	697	25	0	2487	0	WWP1	8	87470164	Frame_Shift_Ins	INS	-	TCGA-BA-5556-01A-01D-1512-08	1695574	87470164	58893858	54	2755											
VPS13B	157680	broad.mit.edu	37	chr8	100523369	100523369	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatggcactcatcagcagcAtggattcctctctctgacat	10	11	8	12	0	4	2	2	1	2	1	6	3	5	3	1	2	2	3	1	2	0	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:100523369A>T	uc003yiv.2	+	29	4448	c.4337A>T	c.(4336-4338)CAT>CTT	p.H1446L	VPS13B_uc003yiw.2_Missense_Mutation_p.H1421L|VPS13B_uc003yix.1_Missense_Mutation_p.H916L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1446					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CATCAGCAGCATGGATTCCTC	0.333													37	161					0	0	0	0	T	100523369	T	T	100523369	3	4	11	1	0	0	0	0	1	0	0	0	17258	217	8	5	4641	5	VPS13B	8	100523369	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	13053205	100523369	45840653	55	2756											
DCAF13	25879	broad.mit.edu	37	chr8	104432504	104432504	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatttcagttccaagaaactAtgatcctgctttacatcctt	11	16	4	10	0	1	2	1	1	0	1	4	2	4	2	3	0	3	2	3	0	5	7			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:104432504A>G	uc003yln.2	+	2	816	c.539A>G	c.(538-540)TAT>TGT	p.Y180C	DCAF13_uc003ylm.1_Intron|DCAF13_uc003ylo.2_5'UTR	NM_015420	NP_056235	Q9NV06	DCA13_HUMAN	WD repeats and SOF1 domain containing	28					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1						CCAAGAAACTATGATCCTGCT	0.358													17	107					0	0	0	0	G	104432504	G	G	104432504	3	3	11	1	0	0	0	0	1	0	0	0	4283	449	16	5	545	5	DCAF13	8	104432504	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	3909135	104432504	41931518	56	2757											
FAM91A1	157769	broad.mit.edu	37	chr8	124796733	124796733	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacctcttgaaggttttgtaAtgaatcgagtgcaaggtgat	11	13	11	6	1	1	3	0	3	1	0	2	4	1	3	1	2	1	3	1	2	4	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:124796733A>G	uc003yqv.2	+	9	788	c.727A>G	c.(727-729)ATG>GTG	p.M243V	FAM91A1_uc011lik.1_Missense_Mutation_p.M243V|FAM91A1_uc011lil.1_Missense_Mutation_p.M1V	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	243										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			AGGTTTTGTAATGAATCGAGT	0.308													5	115					0	0	0	0	G	124796733	G	G	124796733	3	3	11	1	0	0	0	0	1	0	0	0	5683	101	4	5	761	5	FAM91A1	8	124796733	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	20364229	124796733	21567289	57	2758											
PHF20L1	51105	broad.mit.edu	37	chr8	133851650	133851650	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggtcagaggtggagtgcaaAatatcgttatgataaggagt	14	10	14	3	1	1	2	1	1	0	1	2	4	1	4	0	4	1	2	0	4	5	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:133851650A>T	uc003ytt.2	+	18	2535	c.2210A>T	c.(2209-2211)AAA>ATA	p.K737I	PHF20L1_uc011lja.1_Missense_Mutation_p.K711I	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	737							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGGAGTGCAAAATATCGTTAT	0.373													7	154					0	0	0	0	T	133851650	T	T	133851650	3	4	11	1	0	0	0	0	1	0	0	0	11887	14	1	5	2372	5	PHF20L1	8	133851650	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	9054917	133851650	12512372	58	2759											
COL22A1	169044	broad.mit.edu	37	chr8	139601676	139601676	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttagcatagccaggttccccGggttgacctggcccaaggag	8	8	13	12	1	0	1	0	1	0	0	1	2	1	2	5	4	2	3	5	4	3	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:139601676G>A	uc003yvd.2	-	65	5148	c.4701C>T	c.(4699-4701)CCC>CCT	p.P1567P	COL22A1_uc011ljo.1_Silent_p.P847P	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1567	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CAGGTTCCCCGGGTTGACCTG	0.577										HNSCC(7;0.00092)			3	26					0	0	0	0	A	139601676	A	A	139601676	2	1	11	1	0	0	0	0	0	0	0	1	3696	1103	39	1		1	COL22A1	8	139601676	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08	5750026	139601676	6762346	59	2760											
FREM1	158326	broad.mit.edu	37	chr9	14801743	14801743	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcagagaagtctttgctaaAccccctatcgatgaggaggc	11	9	10	11	1	2	2	1	1	1	1	3	5	2	3	2	2	2	1	2	2	4	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr9:14801743A>G	uc003zlm.2	-	20	4191	c.3601T>C	c.(3601-3603)TTT>CTT	p.F1201L	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1201	CSPG 8.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TCTTTGCTAAACCCCCTATCG	0.522													12	129					0	0	0	0	G	14801743	G	G	14801743	3	3	11	1	0	0	0	0	1	0	0	0	6078	43	2	5	3060	5	FREM1	9	14801743	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08		14801743	126411688	60	2761											
KIF24	347240	broad.mit.edu	37	chr9	34255735	34255735	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaaagtgtccaacttactgCgcttgctccagggtgggctg	7	10	14	10	1	0	0	0	0	0	0	2	1	2	1	2	3	4	3	2	3	3	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr9:34255735C>T	uc003zua.3	-	11	3990	c.3870G>A	c.(3868-3870)GCG>GCA	p.A1290A	KIF24_uc010mkb.2_Intron	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	1290					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			CAACTTACTGCGCTTGCTCCA	0.567											OREG0019148	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	38					0	0	0	0	T	34255735	T	T	34255735	2	4	11	1	0	0	0	0	0	0	0	1	8331	755	27	1		1	KIF24	9	34255735	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	19453992	34255735	106957696	61	2762											
WNK2	65268	broad.mit.edu	37	chr9	95993222	95993222	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggttctccgcagctggtgcCggcagatcctgaagggcctg	6	8	15	12	2	1	2	0	1	1	1	3	2	2	2	4	4	2	4	4	4	1	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr9:95993222C>T	uc004ati.1	+	3	907	c.907C>T	c.(907-909)CGG>TGG	p.R303W	WNK2_uc011lud.1_Missense_Mutation_p.R303W|WNK2_uc004atj.2_Missense_Mutation_p.R303W|WNK2_uc010mrc.1_Missense_Mutation_p.R303W|WNK2_uc010mrd.1_5'UTR	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	303	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CAGCTGGTGCCGGCAGATCCT	0.587													25	77					0	0	0	0	T	95993222	T	T	95993222	3	4	11	1	0	0	0	0	1	0	0	0	17446	643	23	1	917	1	WNK2	9	95993222	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	61737487	95993222	45220209	62	2763											
GPR107	57720	broad.mit.edu	37	chr9	132854651	132854651	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catctggattcatatccttcGaaaacgacggtaaactattt	13	13	6	9	3	2	0	1	0	1	0	4	3	3	1	1	2	2	1	1	2	6	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr9:132854651G>A	uc004bze.2	+	9	1081	c.854G>A	c.(853-855)CGA>CAA	p.R285Q	GPR107_uc004bzb.2_Missense_Mutation_p.R96Q|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.R285Q|GPR107_uc004bzd.2_Missense_Mutation_p.R285Q	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	285						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				CATATCCTTCGAAAACGACGG	0.423													62	170					0	0	0	0	A	132854651	A	A	132854651	3	1	11	1	0	0	0	0	1	0	0	0	6661	1058	37	1	888	1	GPR107	9	132854651	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	36861429	132854651	8358780	63	2764											
TPRN	286262	broad.mit.edu	37	chr9	140087090	140087090	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctgctctagggagctctcGgaagggtactcaaatgtggt	8	11	13	9	1	3	0	1	0	2	0	5	2	4	2	1	4	3	3	1	4	4	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr9:140087090G>A	uc004clt.2	-	2	1596	c.1596C>T	c.(1594-1596)TCC>TCT	p.S532S	TPRN_uc004clu.2_Silent_p.S532S	NM_173691	NP_775962	Q4KMQ1	TPRN_HUMAN	hypothetical protein LOC286262 isoform 2	593	Glu-rich.				sensory perception of sound	stereocilium					0						GGGAGCTCTCGGAAGGGTACT	0.358													5	91					0	0	0	0	A	140087090	A	A	140087090	2	1	11	1	0	0	0	0	0	0	0	1	16488	1103	39	1		1	TPRN	9	140087090	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08	7232439	140087090	1126341	64	2765											
GATA3	2625	broad.mit.edu	37	chr10	8100579	8100579	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacgagaaagagtgcctcAagtaccaggtgcccctgccc	11	5	12	13	1	1	2	1	0	0	2	1	4	1	3	5	2	4	1	5	2	3	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr10:8100579A>G	uc001ika.2	+	3	1110	c.553A>G	c.(553-555)AAG>GAG	p.K185E	GATA3_uc001ijz.2_Missense_Mutation_p.K185E	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	185					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						AGAGTGCCTCAAGTACCAGGT	0.701			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						11	97					0	0	0	0	G	8100579	G	G	8100579	3	3	11	1	0	0	0	0	1	0	0	0	6290	131	5	5	559	5	GATA3	10	8100579	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08		8100579	127434168	65	2766											
ANKRD30A	91074	broad.mit.edu	37	chr10	37430782	37430782	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acacctgacacggctgaaagCttggtggaaaaaacacctga	15	6	10	10	1	0	3	0	3	0	0	0	4	0	4	2	3	2	2	2	3	4	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr10:37430782C>A	uc001iza.1	+	7	888	c.789C>A	c.(787-789)AGC>AGA	p.S263R		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	319						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CGGCTGAAAGCTTGGTGGAAA	0.483													8	64					0.000274275	0.000288864	1	0	A	37430782	A	A	37430782	3	1	11	1	0	0	0	0	1	0	0	0	658	796	28	4	815	4	ANKRD30A	10	37430782	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	29330203	37430782	98103965	66	2767											
EXOSC1	51013	broad.mit.edu	37	chr10	99196219	99196219	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcttaggtctgcaagaattCgggttgtactcgggctactt	7	15	11	8	2	2	1	0	0	2	1	4	1	2	1	0	3	3	4	0	3	5	7			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr10:99196219C>T	uc001kni.2	-	8	597	c.571G>A	c.(571-573)GAA>AAA	p.E191K	EXOSC1_uc009xvp.1_RNA	NM_016046	NP_057130	Q9Y3B2	EXOS1_HUMAN	exosomal core protein CSL4	191					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	protein binding|RNA binding				0		Renal(717;0.000147)|Colorectal(252;0.00205)|Ovarian(717;0.00965)		all cancers(201;8.29e-42)|Epithelial(162;5.7e-33)|BRCA - Breast invasive adenocarcinoma(275;0.000315)|Kidney(138;0.000832)|KIRC - Kidney renal clear cell carcinoma(50;0.00269)|STAD - Stomach adenocarcinoma(243;0.202)		TGCAAGAATTCGGGTTGTACT	0.478													17	174					0	0	0	0	T	99196219	T	T	99196219	3	4	11	1	0	0	0	0	1	0	0	0	5337	893	31	1	20	1	EXOSC1	10	99196219	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	61765437	99196219	36338528	67	2768											
HRAS	3265	broad.mit.edu	37	chr11	534286	534286	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgcactcttgcccacacCgccggcgcccaccaccacca	8	3	7	23	4	1	0	0	0	1	0	1	0	1	0	7	1	2	1	7	1	0	1	rs104894228		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:534286C>G	uc001lpv.2	-	2	225	c.37G>C	c.(37-39)GGT>CGT	p.G13R	HRAS_uc010qvw.1_Missense_Mutation_p.G13R|HRAS_uc010qvx.1_Missense_Mutation_p.G13R|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	13	GTP.		G -> D (in FCSS).|G -> C (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(34)|p.G13V(10)|p.G13D(9)|p.G13S(9)|p.G13C(6)|p.G13G(1)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TTGCCCACACCGCCGGCGCCC	0.642		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			8	28					0	0	0	0	G	534286	G	G	534286	3	3	11	1	0	0	0	0	1	0	0	0	7387	652	23	3	615	3	HRAS	11	534286	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08		534286	134472230	68	2769											
MUC2	4583	broad.mit.edu	37	chr11	1087951	1087951	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatgtgggaaccggagcttCgagacctgcaggaccatcaa	11	6	12	12	2	1	1	1	0	0	1	2	5	1	4	4	3	3	2	4	3	2	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:1087951C>T	uc001lsx.1	+	25	3453	c.3426C>T	c.(3424-3426)TTC>TTT	p.F1142F		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	1142						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ACCGGAGCTTCGAGACCTGCA	0.612													3	18					0	0	0	0	T	1087951	T	T	1087951	2	4	11	1	0	0	0	0	0	0	0	1	10028	883	31	1		1	MUC2	11	1087951	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	553665	1087951	133918565	69	2770											
PGAP2	27315	broad.mit.edu	37	chr11	3845337	3845337	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctcgcgttgctagtgctCacttatgtctcctcctccga	6	13	7	15	3	2	0	1	0	1	0	6	1	4	0	4	0	3	3	4	0	3	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:3845337C>T	uc001lys.2	+	4	699	c.573C>T	c.(571-573)CTC>CTT	p.L191L	PGAP2_uc001lyl.2_Silent_p.L148L|PGAP2_uc010qxw.1_Silent_p.L248L|PGAP2_uc010qxx.1_Missense_Mutation_p.H172Y|PGAP2_uc001lyp.3_Intron|PGAP2_uc010qxy.1_Silent_p.L187L|PGAP2_uc010qxz.1_Silent_p.L187L|PGAP2_uc001lyn.3_Missense_Mutation_p.H84Y|PGAP2_uc010qya.1_RNA|PGAP2_uc001lyr.2_Silent_p.L130L|PGAP2_uc010qyb.1_Missense_Mutation_p.H134Y|PGAP2_uc001lyt.2_5'UTR	NM_014489	NP_055304	Q9UHJ9	PGAP2_HUMAN	FGF receptor activating protein 1 isoform 1	191	Helical; (Potential).				GPI anchor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein transporter activity				0						TGCTAGTGCTCACTTATGTCT	0.612													6	38					0	0	0	0	T	3845337	T	T	3845337	2	4	11	1	0	0	0	0	0	0	0	1	11833	826	29	2		2	PGAP2	11	3845337	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	2757386	3845337	131161179	70	2771											
ANO5	203859	broad.mit.edu	37	chr11	22249037	22249037	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgaagtatccccatcctGaatattttactgcacaattc	11	14	6	10	0	0	2	0	2	0	0	3	2	2	2	3	0	2	2	3	0	6	5	rs140381407		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:22249037G>T	uc001mqi.2	+	7	870	c.553G>T	c.(553-555)GAA>TAA	p.E185*	ANO5_uc001mqj.2_Nonsense_Mutation_p.E184*	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	185	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TCCCCATCCTGAATATTTTAC	0.463													18	164					8.00594e-06	8.66216e-06	1	0	T	22249037	T	T	22249037	4	4	11	1	0	0	0	0	0	1	0	0	700	1291	45	2	579	2	ANO5	11	22249037	Nonsense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	18403700	22249037	112757479	71	2772											
PAMR1	25891	broad.mit.edu	37	chr11	35463155	35463155	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgccaattttagcatggcGtccgttgataagcccagggc	8	10	13	10	2	0	1	0	1	0	0	1	1	1	1	3	3	3	2	3	3	3	4	rs149018193		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:35463155G>A	uc001mwg.2	-	7	950	c.907C>T	c.(907-909)CGC>TGC	p.R303C	PAMR1_uc001mwf.2_Missense_Mutation_p.R320C|PAMR1_uc010rew.1_Missense_Mutation_p.R192C|PAMR1_uc010rex.1_Missense_Mutation_p.R263C	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	303	Sushi 1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						TTAGCATGGCGTCCGTTGATA	0.468													50	178					0	0	0	0	A	35463155	A	A	35463155	3	1	11	1	0	0	0	0	1	0	0	0	11467	1145	40	1	1275	1	PAMR1	11	35463155	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	13214118	35463155	99543361	72	2773											
MADD	8567	broad.mit.edu	37	chr11	47330541	47330541	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaattggcaggaagggacaaAggatccatgtgggaccagtt	14	7	14	6	0	0	0	0	0	0	0	1	4	1	4	2	5	0	2	2	5	3	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:47330541A>G	uc001ner.1	+	26	4070	c.3879A>G	c.(3877-3879)AAA>AAG	p.K1293K	MADD_uc001neq.2_Intron|MADD_uc001nev.1_Intron|MADD_uc001nes.1_Intron|MADD_uc001net.1_Intron|MADD_uc009yln.1_Intron|MADD_uc001neu.1_Intron|MADD_uc001nex.2_Silent_p.K1293K|MADD_uc001nez.2_Intron|MADD_uc001new.2_Intron|MADD_uc009ylo.2_Silent_p.K207K	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1293					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		GAAGGGACAAAGGATCCATGT	0.458													36	172					0	0	0	0	G	47330541	G	G	47330541	2	3	11	1	0	0	0	0	0	0	0	1	9203	69	3	5		5	MADD	11	47330541	Silent	SNP	A	TCGA-BA-5556-01A-01D-1512-08	11867386	47330541	87675975	73	2774											
OR8J3	81168	broad.mit.edu	37	chr11	55904306	55904306	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttctttaaggcaacatttaCatcattattcctcaggctgt	10	17	5	9	0	3	0	2	0	1	0	4	0	4	0	1	2	2	2	1	2	4	7			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:55904306C>A	uc010riz.1	-	1	889	c.889G>T	c.(889-891)GTA>TTA	p.V297L		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					GCAACATTTACATCATTATTC	0.338													20	141					3.99206e-14	4.62238e-14	1	0	A	55904306	A	A	55904306	3	1	11	1	0	0	0	0	1	0	0	0	11296	478	17	4	60	4	OR8J3	11	55904306	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	8573765	55904306	79102210	74	2775											
OR9Q1	219956	broad.mit.edu	37	chr11	57947391	57947391	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctcatcagtgccttggtgCggacagtctcagccttcact	6	12	10	13	1	4	0	4	0	2	0	6	1	4	1	2	2	3	0	2	2	0	2	rs2513718		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:57947391C>T	uc001nmj.2	+	3	791	c.475C>T	c.(475-477)CGG>TGG	p.R159W		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				TGCCTTGGTGCGGACAGTCTC	0.537													24	62					0	0	0	0	T	57947391	T	T	57947391	3	4	11	1	0	0	0	0	1	0	0	0	11309	759	27	1	477	1	OR9Q1	11	57947391	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	2043085	57947391	77059125	75	2776											
OR1S1	219959	broad.mit.edu	37	chr11	57982965	57982965	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacacagggaaagtggaaagCcttctccacttgtggctctc	10	9	10	12	0	2	0	0	0	2	0	4	2	2	2	2	3	1	1	2	3	2	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:57982965C>T	uc010rkc.1	+	1	749	c.749C>T	c.(748-750)GCC>GTC	p.A250V		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				AAGTGGAAAGCCTTCTCCACT	0.468													25	110					0	0	0	0	T	57982965	T	T	57982965	3	4	11	1	0	0	0	0	1	0	0	0	11026	739	26	4	751	4	OR1S1	11	57982965	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	35574	57982965	77023551	76	2777											
OR4D10	390197	broad.mit.edu	37	chr11	59244959	59244959	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttccttggcctgacccaGaatcgggaagtgagcttagt	9	12	11	9	1	0	3	0	2	0	1	2	4	1	4	3	2	1	1	3	2	3	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:59244959G>A	uc001nnz.1	+	1	57	c.57G>A	c.(55-57)CAG>CAA	p.Q19Q		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GCCTGACCCAGAATCGGGAAG	0.403													5	162					0	0	0	0	A	59244959	A	A	59244959	2	1	11	1	0	0	0	0	0	0	0	1	11108	933	33	2		2	OR4D10	11	59244959	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08	1261994	59244959	75761557	77	2778											
NRXN2	9379	broad.mit.edu	37	chr11	64397889	64397889	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctacctgccgggtaccgctCgttgaccggccagctgtcca	5	8	11	17	4	0	1	0	1	0	0	2	1	1	1	7	2	4	4	7	2	2	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:64397889C>T	uc001oap.2	-	4	1115	c.604G>A	c.(604-606)GAG>AAG	p.E202K	NRXN2_uc001oar.2_Missense_Mutation_p.E1248K|NRXN2_uc001oas.2_Missense_Mutation_p.E1208K|NRXN2_uc001oaq.2_Missense_Mutation_p.E915K	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	202	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GGGTACCGCTCGTTGACCGGC	0.507													10	60					0	0	0	0	T	64397889	T	T	64397889	3	4	11	1	0	0	0	0	1	0	0	0	10720	893	31	1	1416	1	NRXN2	11	64397889	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	5152930	64397889	70608627	78	2779											
SF1	7536	broad.mit.edu	37	chr11	64536792	64536792	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctggagtctcgataccctGcttcaggatgtttcttatct	6	16	8	11	1	5	0	1	0	4	0	6	3	5	2	1	2	2	2	1	2	2	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:64536792G>A	uc001obb.1	-	7	1059	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	SF1_uc010rnm.1_5'Flank|SF1_uc010rnn.1_Nonsense_Mutation_p.Q202*|SF1_uc001oaz.1_Nonsense_Mutation_p.Q353*|SF1_uc001oba.1_Nonsense_Mutation_p.Q228*|SF1_uc001obc.1_Nonsense_Mutation_p.Q228*|SF1_uc001obd.1_Nonsense_Mutation_p.Q228*|SF1_uc001obe.1_Nonsense_Mutation_p.Q113*|SF1_uc010rno.1_Nonsense_Mutation_p.Q113*	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	228					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						TCGATACCCTGCTTCAGGATG	0.502													6	121					0	0	0	0	A	64536792	A	A	64536792	4	1	11	1	0	0	0	0	0	1	0	0	14210	1328	46	4	1403	4	SF1	11	64536792	Nonsense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	138903	64536792	70469724	79	2780											
C11orf30	56946	broad.mit.edu	37	chr11	76171120	76171120	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgccaagtggaagtactgttTatgtcaaaagtaagtgatat	14	13	10	4	0	1	1	1	1	0	0	1	2	1	2	1	1	2	3	1	1	8	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:76171120T>C	uc001oxl.2	+	6	705	c.562T>C	c.(562-564)TAT>CAT	p.Y188H	C11orf30_uc001oxk.2_3'UTR|C11orf30_uc009yuj.1_Missense_Mutation_p.Y203H|C11orf30_uc010rsa.1_Intron|C11orf30_uc001oxm.2_Missense_Mutation_p.Y189H|C11orf30_uc010rsb.1_Missense_Mutation_p.Y203H|C11orf30_uc010rsc.1_Missense_Mutation_p.Y203H|C11orf30_uc001oxn.2_Missense_Mutation_p.Y189H|C11orf30_uc010rsd.1_Missense_Mutation_p.Y202H	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	188	Interaction with BRCA2.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						AAGTACTGTTTATGTCAAAAG	0.458													45	309					0	0	0	0	C	76171120	C	C	76171120	3	2	11	1	0	0	0	0	1	0	0	0	1642	1754	61	5	580	5	C11orf30	11	76171120	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	11634328	76171120	58835396	80	2781											
CNTN5	53942	broad.mit.edu	37	chr11	100179177	100179177	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaacacattaaagagagtCtaggaagaccacagggattt	17	7	11	6	0	1	2	0	0	1	2	1	6	1	5	1	3	1	0	1	3	5	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:100179177C>G	uc001pga.2	+	21	3046	c.2707C>G	c.(2707-2709)CTA>GTA	p.L903V	CNTN5_uc001pfz.2_Missense_Mutation_p.L903V|CNTN5_uc001pgb.2_Missense_Mutation_p.L829V|CNTN5_uc010ruk.1_Missense_Mutation_p.L174V	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	903	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TAAAGAGAGTCTAGGAAGACC	0.418													8	49					0	0	0	0	G	100179177	G	G	100179177	3	3	11	1	0	0	0	0	1	0	0	0	3659	912	32	2	2781	2	CNTN5	11	100179177	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	24008057	100179177	34827339	81	2782											
HTR3B	9177	broad.mit.edu	37	chr11	113803138	113803138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catatgcttttccatttgatGtccagaattgcagcctgacc	9	14	7	11	0	0	3	0	2	0	1	2	3	2	3	4	0	3	2	4	0	2	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:113803138G>A	uc001pok.2	+	5	563	c.496G>A	c.(496-498)GTC>ATC	p.V166I	HTR3B_uc001pol.2_Missense_Mutation_p.V155I	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	166	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TCCATTTGATGTCCAGAATTG	0.428													4	144					0	0	0	0	A	113803138	A	A	113803138	3	1	11	1	0	0	0	0	1	0	0	0	7484	1377	48	4	514	4	HTR3B	11	113803138	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	13623961	113803138	21203378	82	2783											
BSX	390259	broad.mit.edu	37	chr11	122849989	122849989	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgtctcggacaggctgaGggccgtggccagctccactc	5	7	14	15	3	1	1	0	1	1	0	4	2	2	2	3	4	2	2	3	4	0	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:122849989G>A	uc010rzs.1	-	2	439	c.439C>T	c.(439-441)CTC>TTC	p.L147F		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	147	Homeobox.										0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		GACAGGCTGAGGGCCGTGGCC	0.612													43	119					0	0	0	0	A	122849989	A	A	122849989	3	1	11	1	0	0	0	0	1	0	0	0	1540	1000	35	4	269	4	BSX	11	122849989	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	9046851	122849989	12156527	83	2784											
OR6T1	219874	broad.mit.edu	37	chr11	123813728	123813728	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcagctcaggacggaggcaCctttgttgagcagtttggac	8	10	14	9	1	1	1	1	1	0	0	1	4	1	4	1	4	3	6	1	4	0	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:123813728C>A	uc010sab.1	-	1	818	c.818G>T	c.(817-819)GGT>GTT	p.G273V		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GACGGAGGCACCTTTGTTGAG	0.512													70	226					5.02462e-34	6.02955e-34	1	0	A	123813728	A	A	123813728	3	1	11	1	0	0	0	0	1	0	0	0	11264	507	18	4	156	4	OR6T1	11	123813728	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	963739	123813728	11192788	84	2785											
DYRK4	8798	broad.mit.edu	37	chr12	4721794	4721794	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaacctcaagccacagcccAggccccagaccctgaggaaa	13	2	10	16	0	1	2	1	1	0	1	1	4	1	4	6	3	3	0	6	3	3	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:4721794A>T	uc001qmx.2	+	12	1391	c.1231A>T	c.(1231-1233)AGG>TGG	p.R411W	DYRK4_uc009zeh.1_Missense_Mutation_p.R526W|DYRK4_uc001qmy.1_Missense_Mutation_p.R411W|DYRK4_uc001qmz.1_Missense_Mutation_p.R125W|DYRK4_uc001qna.1_Missense_Mutation_p.R48W|DYRK4_uc010ser.1_Missense_Mutation_p.R48W	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	411						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			GCCACAGCCCAGGCCCCAGAC	0.542													23	149					0	0	0	0	T	4721794	T	T	4721794	3	4	11	1	0	0	0	0	1	0	0	0	4880	179	7	5	1269	5	DYRK4	12	4721794	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08		4721794	129130101	85	2786											
RERG	85004	broad.mit.edu	37	chr12	15262344	15262344	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttttgatctcatctaggatGttcttaagtggcagcacttc	8	17	8	8	0	3	1	1	1	3	0	5	2	3	2	0	2	1	3	0	2	2	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:15262344G>A	uc001rcs.2	-	4	440	c.300C>T	c.(298-300)AAC>AAT	p.N100N	RERG_uc001rct.2_Silent_p.N100N|RERG_uc010shu.1_Silent_p.N81N	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	100					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						CATCTAGGATGTTCTTAAGTG	0.498													91	414					0	0	0	0	A	15262344	A	A	15262344	2	1	11	1	0	0	0	0	0	0	0	1	13297	1368	48	4		4	RERG	12	15262344	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08	10540550	15262344	118589551	86	2787											
SFRS2IP	9169	broad.mit.edu	37	chr12	46316327	46316327	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaaatggcttgatggccaaTtttacctcttgtgctgcttt	8	17	8	8	0	1	1	0	1	1	0	1	1	1	1	2	2	3	3	2	2	4	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:46316327T>C	uc001rox.2	-	14	4451	c.4164A>G	c.(4162-4164)AAA>AAG	p.K1388K	SFRS2IP_uc001row.2_Silent_p.K1073K	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1388					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		TGATGGCCAATTTTACCTCTT	0.323													20	96					0	0	0	0	C	46316327	C	C	46316327	2	2	11	1	0	0	0	0	0	0	0	1	14242	1490	52	5		5	SFRS2IP	12	46316327	Silent	SNP	T	TCGA-BA-5556-01A-01D-1512-08	31053983	46316327	87535568	87	2788											
DIP2B	57609	broad.mit.edu	37	chr12	51080428	51080428	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgaaagactggcagccacAcatctcacctgctgggacag	12	5	10	14	1	1	1	1	0	1	1	2	3	1	2	3	2	2	2	3	2	1	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:51080428A>T	uc001rwv.2	+	12	1670	c.1514A>T	c.(1513-1515)CAC>CTC	p.H505L	DIP2B_uc009zlt.2_5'UTR	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	505						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TGGCAGCCACACATCTCACCT	0.458													4	24					0	0	0	0	T	51080428	T	T	51080428	3	4	11	1	0	0	0	0	1	0	0	0	4550	159	6	5	1560	5	DIP2B	12	51080428	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	4764101	51080428	82771467	88	2789											
NAV3	89795	broad.mit.edu	37	chr12	78452823	78452823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atatactagaagtctgaaccGaataccagacacagcaactt	17	8	6	10	1	1	3	0	1	1	2	1	4	1	3	2	0	5	1	2	0	8	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:78452823G>A	uc001syp.2	+	12	2737	c.2564G>A	c.(2563-2565)CGA>CAA	p.R855Q	NAV3_uc001syo.2_Missense_Mutation_p.R855Q|NAV3_uc010sub.1_Missense_Mutation_p.R355Q	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	855						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGTCTGAACCGAATACCAGAC	0.413										HNSCC(70;0.22)			20	89					0	0	0	0	A	78452823	A	A	78452823	3	1	11	1	0	0	0	0	1	0	0	0	10238	1058	37	1	2610	1	NAV3	12	78452823	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	27372395	78452823	55399072	89	2790											
HNF1A	6927	broad.mit.edu	37	chr12	121431330	121431330	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctgtgcctgcagagttcacCcatgcagggcagggagggct	7	8	15	11	0	2	1	1	0	1	1	2	2	2	2	2	3	3	5	2	3	0	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:121431330C>T	uc001tzg.2	+	3	557	c.534C>T	c.(532-534)ACC>ACT	p.T178T	HNF1A_uc001tze.1_Silent_p.T178T|HNF1A_uc001tzf.2_Silent_p.T178T|HNF1A_uc010szn.1_Silent_p.T178T	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	178					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAGAGTTCACCCATGCAGGGC	0.587									Hepatic_Adenoma_Familial_Clustering_of				6	38					0	0	0	0	T	121431330	T	T	121431330	2	4	11	1	0	0	0	0	0	0	0	1	7290	610	22	4		4	HNF1A	12	121431330	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	42978507	121431330	12420565	90	2791											
OASL	8638	broad.mit.edu	37	chr12	121461833	121461833	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggggttctccctgttgtcaTagcaacagtcctgtttcagg	6	14	11	10	0	3	0	2	0	1	0	5	0	4	0	2	3	2	4	2	3	2	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:121461833T>C	uc001tzj.1	-	5	1013	c.1007A>G	c.(1006-1008)TAT>TGT	p.Y336C	OASL_uc001tzk.1_Silent_p.L255L	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	336					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCTGTTGTCATAGCAACAGTC	0.557													5	102					0	0	0	0	C	121461833	C	C	121461833	3	2	11	1	0	0	0	0	1	0	0	0	10856	1406	49	5	545	5	OASL	12	121461833	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	30503	121461833	12390062	91	2792											
MIPEP	4285	broad.mit.edu	37	chr13	24460635	24460635	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggcactcagctcaggaactCcaaaaagacccttagaacca	15	5	8	13	0	2	2	2	0	0	2	3	3	3	3	3	2	3	2	3	2	5	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:24460635C>T	uc001uox.3	-	2	300	c.200G>A	c.(199-201)GGA>GAA	p.G67E	PCOTH_uc001uoy.2_5'Flank|PCOTH_uc009zzx.2_5'Flank	NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	67					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		CTCAGGAACTCCAAAAAGACC	0.373													25	120					0	0	0	0	T	24460635	T	T	24460635	3	4	11	1	0	0	0	0	1	0	0	0	9645	855	30	2	2013	2	MIPEP	13	24460635	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08		24460635	90709243	92	2793											
ATP12A	479	broad.mit.edu	37	chr13	25276139	25276139	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagagtgtggggatcattTcagccaacagtgaaacagtg	13	8	12	8	0	2	2	2	1	0	1	2	3	2	3	2	2	3	0	2	2	3	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:25276139T>C	uc001upp.2	+	14	2135	c.1948T>C	c.(1948-1950)TCA>CCA	p.S650P	ATP12A_uc010aaa.2_Missense_Mutation_p.S656P	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	650	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GGGGATCATTTCAGCCAACAG	0.458													22	131					0	0	0	0	C	25276139	C	C	25276139	3	2	11	1	0	0	0	0	1	0	0	0	1124	1783	62	5	2020	5	ATP12A	13	25276139	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	815504	25276139	89893739	93	2794											
FRY	10129	broad.mit.edu	37	chr13	32841345	32841345	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggagtctctccccctccctCgcccttcttctcagccatcc	3	11	6	21	1	3	0	1	0	3	0	9	1	6	1	6	1	1	0	6	1	0	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:32841345C>T	uc001utx.2	+	55	8481	c.7985C>T	c.(7984-7986)TCG>TTG	p.S2662L	FRY_uc010tdw.1_RNA|FRY_uc001uty.2_Missense_Mutation_p.S217L|FRY_uc001utz.2_Missense_Mutation_p.S187L|FRY_uc010tdx.1_Missense_Mutation_p.S32L	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2662					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCCCCTCCCTCGCCCTTCTTC	0.537													47	230					0	0	0	0	T	32841345	T	T	32841345	3	4	11	1	0	0	0	0	1	0	0	0	6097	893	31	1	8203	1	FRY	13	32841345	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	7565206	32841345	82328533	94	2795											
LRCH1	23143	broad.mit.edu	37	chr13	47260079	47260079	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtaaagtttgacttttcctGcaacaaagtgctcgtgattc	10	14	9	8	1	0	2	0	2	0	0	3	2	1	2	1	1	3	4	1	1	4	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:47260079G>C	uc001vbj.2	+	5	961	c.725G>C	c.(724-726)TGC>TCC	p.C242S	LRCH1_uc010acp.2_Missense_Mutation_p.C242S|LRCH1_uc001vbk.2_Missense_Mutation_p.C242S|LRCH1_uc001vbl.3_Missense_Mutation_p.C242S	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	242	LRR 7.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GACTTTTCCTGCAACAAAGTG	0.323													7	55					0	0	0	0	C	47260079	C	C	47260079	3	2	11	1	0	0	0	0	1	0	0	0	8982	1319	46	4	743	4	LRCH1	13	47260079	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	14418734	47260079	67909799	95	2796											
WDFY2	115825	broad.mit.edu	37	chr13	52313218	52313218	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctgttgggacccagtccAgcgggtgttgttctcaggca	5	12	13	11	1	2	0	1	0	2	0	5	1	3	1	2	3	1	4	2	3	0	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:52313218A>T	uc001vfp.2	+	7	972	c.632A>T	c.(631-633)CAG>CTG	p.Q211L	WDFY2_uc010ads.1_Missense_Mutation_p.Q211L|WDFY2_uc010adt.1_RNA	NM_052950	NP_443182	Q96P53	WDFY2_HUMAN	WD repeat and FYVE domain containing 2	211	WD 5.						metal ion binding				0		Breast(56;0.000208)|Lung NSC(96;0.000517)|Prostate(109;0.0041)|Hepatocellular(98;0.0652)|Myeloproliferative disorder(33;0.164)|all_neural(104;0.191)		GBM - Glioblastoma multiforme(99;9e-08)		GACCCAGTCCAGCGGGTGTTG	0.512													43	215					0	0	0	0	T	52313218	T	T	52313218	3	4	11	1	0	0	0	0	1	0	0	0	17337	188	7	5	658	5	WDFY2	13	52313218	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	5053139	52313218	62856660	96	2797											
MYCBP2	23077	broad.mit.edu	37	chr13	77625189	77625190	+	Frame_Shift_Ins	INS	-	A	A																															gtcattctttgaaaatcatcINSatgacaagcattacaaaaat																										TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:77625189_77625190insA	uc001vkf.2	-	83	13840_13841	c.13749_13750insT	c.(13747-13752)CATGATfs	p.H4583fs	MYCBP2_uc010aev.2_Frame_Shift_Ins_p.H3987fs|MYCBP2_uc001vke.2_Frame_Shift_Ins_p.H1200fs	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4583_4584	B box-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGAAAATCATCATGACAAGCAT	0.347													---	---	---								A	77625190	A	A	77625189	7	5	11	1	0	1	1	0	0	0	0	0	10071	826	29	0	180	0	MYCBP2	13	77625189	Frame_Shift_Ins	INS	-	TCGA-BA-5556-01A-01D-1512-08	25311971	77625189	37544689	97	2798											
SLITRK5	26050	broad.mit.edu	37	chr13	88329623	88329623	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaggcggaggggcgtcgtcGgtgcccttgtctgtgttaat	4	11	17	9	4	1	0	0	0	1	0	3	1	1	1	1	5	1	2	1	5	1	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:88329623G>A	uc001vln.2	+	2	2199	c.1980G>A	c.(1978-1980)TCG>TCA	p.S660S	SLITRK5_uc010tic.1_Silent_p.S419S	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	660	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GGGCGTCGTCGGTGCCCTTGT	0.642													7	51					0	0	0	0	A	88329623	A	A	88329623	2	1	11	1	0	0	0	0	0	0	0	1	14810	1103	39	1		1	SLITRK5	13	88329623	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08	10704434	88329623	26840255	98	2799											
GPC6	10082	broad.mit.edu	37	chr13	94482798	94482798	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgcaaaccgagtttccaaGgtaattgaaaacgtgctttc	12	12	9	8	2	0	1	0	1	0	0	2	2	1	1	2	1	4	5	2	1	5	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:94482798G>T	uc001vlt.2	+	3	1343	c.711G>T	c.(709-711)AAG>AAT	p.K237N	GPC6_uc010tig.1_Missense_Mutation_p.K237N|GPC6_uc001vlu.1_Missense_Mutation_p.K167N	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	237						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GAGTTTCCAAGGTAATTGAAA	0.398													9	61					1.12685e-05	1.21259e-05	1	0	T	94482798	T	T	94482798	3	4	11	1	0	0	0	0	1	0	0	0	6640	1014	35	4	721	4	GPC6	13	94482798	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	6153175	94482798	20687080	99	2800											
SLC10A2	6555	broad.mit.edu	37	chr13	103710731	103710731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcatgtggtcatgctgaCgctgaaaggcaatgggcaga	11	7	16	7	1	1	3	1	2	0	1	1	4	1	4	0	4	2	5	0	4	2	0	rs150843319	by1000genomes	TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:103710731C>T	uc001vpy.3	-	2	976	c.379G>A	c.(379-381)GTC>ATC	p.V127I		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	127	Helical; (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GTCATGCTGACGCTGAAAGGC	0.408													14	84					0	0	0	0	T	103710731	T	T	103710731	3	4	11	1	0	0	0	0	1	0	0	0	14439	550	19	1	687	1	SLC10A2	13	103710731	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	9227933	103710731	11459147	100	2801											
REM2	161253	broad.mit.edu	37	chr14	23355326	23355326	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaccgacggagtttctccAaagttccagagaccctactt	10	9	8	14	3	1	1	0	0	1	1	3	5	2	2	5	1	1	2	5	1	2	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:23355326A>G	uc001whf.1	+	4	678	c.613A>G	c.(613-615)AAA>GAA	p.K205E	REM2_uc010tnd.1_Missense_Mutation_p.Q172R	NM_173527	NP_775798	Q8IYK8	REM2_HUMAN	rad and gem related GTP binding protein 2	205					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)		GAGTTTCTCCAAAGTTCCAGA	0.627													13	73					0	0	0	0	G	23355326	G	G	23355326	3	3	11	1	0	0	0	0	1	0	0	0	13288	131	5	5	627	5	REM2	14	23355326	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08		23355326	83994214	101	2802											
JUB	84962	broad.mit.edu	37	chr14	23444270	23444270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttgttgcaaacaatgcatCggaaacagcctggatgatag	14	9	10	8	1	0	1	0	1	0	0	1	3	0	3	1	2	5	3	1	2	4	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:23444270C>T	uc001whz.2	-	5	1659	c.1283G>A	c.(1282-1284)CGA>CAA	p.R428Q	JUB_uc001why.2_Missense_Mutation_p.R11Q	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	428	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		AACAATGCATCGGAAACAGCC	0.532													5	106					0	0	0	0	T	23444270	T	T	23444270	3	4	11	1	0	0	0	0	1	0	0	0	8007	884	31	1	349	1	JUB	14	23444270	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	88944	23444270	83905270	102	2803											
JUB	84962	broad.mit.edu	37	chr14	23450566	23450567	+	Frame_Shift_Ins	INS	-	C	C																															tccagacccgacggctcaatINSccccgagggttctccgcggg																										TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:23450566_23450567insC	uc001whz.2	-	1	1285_1286	c.909_910insG	c.(907-912)GGGATTfs	p.G303fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	303_304	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		GACGGCTCAATCCCCGAGGGTT	0.703													---	---	---								C	23450567	C	C	23450566	7	5	11	1	0	1	1	0	0	0	0	0	8007	1435	50	0	738	0	JUB	14	23450566	Frame_Shift_Ins	INS	-	TCGA-BA-5556-01A-01D-1512-08	6296	23450566	83898974	103	2804											
CDKL1	8814	broad.mit.edu	37	chr14	50863888	50863888	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaagacgcctgcgctaggAgcccctcctgagcggtccac	8	5	12	16	3	0	2	0	1	0	1	2	3	2	3	5	2	4	2	5	2	2	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:50863888A>T	uc010anu.1	-	4	402	c.402T>A	c.(400-402)GCT>GCA	p.A134A	CDKL1_uc001wxz.2_5'Flank	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	Error:Variant_position_missing_in_Q00532_after_alignment						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					CTGCGCTAGGAGCCCCTCCTG	0.602													5	45					0	0	0	0	T	50863888	T	T	50863888	2	4	11	1	0	0	0	0	0	0	0	1	3168	319	11	5		5	CDKL1	14	50863888	Silent	SNP	A	TCGA-BA-5556-01A-01D-1512-08	27413322	50863888	56485652	104	2805											
RDH12	145226	broad.mit.edu	37	chr14	68191267	68191267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgatcactggcgccaacaCgggcattggcaaggagacgg	10	5	16	10	3	1	2	1	1	0	1	1	3	1	2	1	6	1	2	1	6	2	1	rs28940314		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:68191267C>T	uc001xjz.3	+	4	470	c.146C>T	c.(145-147)ACG>ATG	p.T49M		NM_152443	NP_689656	Q96NR8	RDH12_HUMAN	retinol dehydrogenase 12	49	NADP (By similarity).				photoreceptor cell maintenance|response to stimulus|retinol metabolic process	intracellular	binding|retinol dehydrogenase activity			ovary(1)	1				all cancers(60;0.000704)|OV - Ovarian serous cystadenocarcinoma(108;0.00161)|BRCA - Breast invasive adenocarcinoma(234;0.00953)	Vitamin A(DB00162)	GGCGCCAACACGGGCATTGGC	0.557													19	72					0	0	0	0	T	68191267	T	T	68191267	3	4	11	1	0	0	0	0	1	0	0	0	13256	536	19	1	152	1	RDH12	14	68191267	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	17327379	68191267	39158273	105	2806											
C14orf118	55668	broad.mit.edu	37	chr14	76642983	76642983	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taggagaccagcataaacacTttggggactgagaggataag	15	7	13	6	0	0	2	0	1	0	2	0	6	0	4	1	4	2	1	1	4	4	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:76642983T>G	uc001xsh.2	+	6	1088	c.1002T>G	c.(1000-1002)ACT>ACG	p.T334T	C14orf118_uc001xsi.2_Silent_p.T334T|C14orf118_uc001xsj.1_3'UTR|C14orf118_uc001xsk.1_3'UTR|C14orf118_uc001xsl.2_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	334										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		GCATAAACACTTTGGGGACTG	0.413													27	152					0	0	0	0	G	76642983	G	G	76642983	2	3	11	1	0	0	0	0	0	0	0	1	1747	1596	56	5		5	C14orf118	14	76642983	Silent	SNP	T	TCGA-BA-5556-01A-01D-1512-08	8451716	76642983	30706557	106	2807											
PPP4R4	57718	broad.mit.edu	37	chr14	94711996	94711996	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtggagaaagcagtgttCaagaaaataaggtaaacttc	16	9	11	5	0	1	2	1	0	0	2	2	3	1	2	0	3	2	3	0	3	7	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:94711996C>T	uc001ycs.1	+	13	1571	c.1417C>T	c.(1417-1419)CAA>TAA	p.Q473*		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	473						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						AAGCAGTGTTCAAGAAAATAA	0.249													25	148					0	0	0	0	T	94711996	T	T	94711996	4	4	11	1	0	0	0	0	0	1	0	0	12465	827	29	2	1540	2	PPP4R4	14	94711996	Nonsense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	18069013	94711996	12637544	107	2808											
C15orf2	23742	broad.mit.edu	37	chr15	24923846	24923846	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcagcataattccaccaggTtttgcagagttaacatcacc	12	10	8	11	0	1	1	1	0	0	1	2	1	2	1	3	2	3	5	3	2	2	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:24923846T>C	uc001ywo.2	+	1	3306	c.2832T>C	c.(2830-2832)GGT>GGC	p.G944G		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	944					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TTCCACCAGGTTTTGCAGAGT	0.483													24	108					0	0	0	0	C	24923846	C	C	24923846	2	2	11	1	0	0	0	0	0	0	0	1	1790	1712	60	5		5	C15orf2	15	24923846	Silent	SNP	T	TCGA-BA-5556-01A-01D-1512-08		24923846	77607546	108	2809											
MTMR15	22909	broad.mit.edu	37	chr15	31229329	31229329	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttcttttccagctggtggAagttaaaggccccaatgatc	10	13	9	9	0	1	1	0	1	1	0	3	2	2	2	3	3	1	2	3	3	4	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:31229329A>G	uc001zff.2	+	14	3215	c.2924A>G	c.(2923-2925)GAA>GGA	p.E975G	MTMR15_uc001zfe.2_Missense_Mutation_p.E580G	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	975	VRR-NUC.			E->A: Loss of nuclease activity; when associated with A-864; A-960 and A-977.	double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		CAGCTGGTGGAAGTTAAAGGC	0.398								Direct_reversal_of_damage|Editing_and_processing_nucleases					14	134					0	0	0	0	G	31229329	G	G	31229329	3	3	11	1	0	0	0	0	1	0	0	0	9996	246	9	5	2999	5	MTMR15	15	31229329	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	6305483	31229329	71302063	109	2810											
RYR3	6263	broad.mit.edu	37	chr15	34040349	34040349	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcgctggcctgcgcgagagtCcctgaaaaccatgctggctg	7	8	13	13	3	0	2	0	1	0	1	2	3	1	2	3	2	3	3	3	2	2	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:34040349C>G	uc001zhi.2	+	54	8094	c.8024C>G	c.(8023-8025)TCC>TGC	p.S2675C	RYR3_uc010bar.2_Missense_Mutation_p.S2675C	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2675	3.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCGCGAGAGTCCCTGAAAACC	0.527													16	99					0	0	0	0	G	34040349	G	G	34040349	3	3	11	1	0	0	0	0	1	0	0	0	13835	855	30	2	8238	2	RYR3	15	34040349	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	2811020	34040349	68491043	110	2811											
TYRO3	7301	broad.mit.edu	37	chr15	41870164	41870164	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgcgaatggaactggagaAcatcttgggccagctgtctg	9	10	13	9	1	3	1	0	0	3	1	3	4	3	2	1	3	4	1	1	3	3	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:41870164A>T	uc001zof.1	+	19	2587	c.2363A>T	c.(2362-2364)AAC>ATC	p.N788I		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	788	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GAACTGGAGAACATCTTGGGC	0.572													9	102					0	0	0	0	T	41870164	T	T	41870164	3	4	11	1	0	0	0	0	1	0	0	0	16882	43	2	5	2437	5	TYRO3	15	41870164	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	7829815	41870164	60661228	111	2812											
TP53BP1	7158	broad.mit.edu	37	chr15	43701208	43701209	+	Frame_Shift_Ins	INS	-	G	G																															cccagacatgagacacacaaINSggaatcccactggcaaggca																										TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:43701208_43701209insG	uc001zrs.2	-	26	5619_5620	c.5471_5472insC	c.(5470-5472)CCTfs	p.P1824fs	TP53BP1_uc010udp.1_Frame_Shift_Ins_p.P1822fs|TP53BP1_uc001zrq.3_Frame_Shift_Ins_p.P1827fs|TP53BP1_uc001zrr.3_Frame_Shift_Ins_p.P1829fs|TP53BP1_uc001zrp.2_Frame_Shift_Ins_p.P241fs	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1824	BRCT 1.				double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GAGACACACAAGGAATCCCACT	0.49								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					---	---	---								G	43701209	G	G	43701208	7	5	11	1	0	1	1	0	0	0	0	0	16450	59	3	0	458	0	TP53BP1	15	43701208	Frame_Shift_Ins	INS	-	TCGA-BA-5556-01A-01D-1512-08	1831044	43701208	58830184	112	2813											
DMXL2	23312	broad.mit.edu	37	chr15	51806663	51806663	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatggctgaaaaaatatttCtgtttcctttttctccatat	10	19	5	7	0	2	2	0	2	2	0	4	2	3	2	2	1	0	2	2	1	5	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:51806663C>G	uc002abf.2	-	15	2845	c.2620G>C	c.(2620-2622)GAA>CAA	p.E874Q	DMXL2_uc010ufy.1_Missense_Mutation_p.E874Q|DMXL2_uc010bfa.2_Missense_Mutation_p.E874Q	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	874						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		AAAAATATTTCTGTTTCCTTT	0.318													32	213					0	0	0	0	G	51806663	G	G	51806663	3	3	11	1	0	0	0	0	1	0	0	0	4617	922	32	2	6609	2	DMXL2	15	51806663	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	8105455	51806663	50724729	113	2814											
ANPEP	290	broad.mit.edu	37	chr15	90328694	90328694	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agggcccgggtgcctgagccGaagcctgtttcctcgttgtc	4	10	14	13	3	0	1	0	1	0	0	3	2	1	1	5	2	3	2	5	2	1	2	rs145116014		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:90328694G>A	uc002bop.3	-	21	3082	c.2790C>T	c.(2788-2790)TTC>TTT	p.F930F		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	930	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TGCCTGAGCCGAAGCCTGTTT	0.562													14	212					0	0	0	0	A	90328694	A	A	90328694	2	1	11	1	0	0	0	0	0	0	0	1	710	1049	37	1		1	ANPEP	15	90328694	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08	38522031	90328694	12202698	114	2815											
METRN	79006	broad.mit.edu	37	chr16	765975	765975	+	Frame_Shift_Del	DEL	G	-	-																															ccccgcaggcccacggtctcGgcgtagacggtgagtggcgg																										TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr16:765975delG	uc002cjd.2	+	2	613	c.496delG	c.(496-498)GGCfs	p.G166fs	uc010bra.1_5'Flank	NM_024042	NP_076947	Q9UJH8	METRN_HUMAN	meteorin, glial cell differentiation regulator	166											0		Hepatocellular(780;0.00335)				CCACGGTCTCGGCGTAGACGG	0.711													---	---	---								-	765975	-	-	765975	7	5	11	1	0	1	0	1	0	0	0	0	9541	1116	39	0	502	0	METRN	16	765975	Frame_Shift_Del	DEL	G	TCGA-BA-5556-01A-01D-1512-08		765975	89588778	115	2816											
ZSCAN10	84891	broad.mit.edu	37	chr16	3140386	3140386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagctcaccccgcagtccGcgcagatgaactgcaactcc	10	5	10	16	3	1	2	1	1	0	1	3	3	3	3	4	1	4	4	4	1	3	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr16:3140386G>A	uc002ctv.1	-	5	972	c.884C>T	c.(883-885)GCG>GTG	p.A295V	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Missense_Mutation_p.A213V|ZSCAN10_uc002ctx.1_Missense_Mutation_p.A223V	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	295	C2H2-type 1.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CCCGCAGTCCGCGCAGATGAA	0.637													7	129					0	0	0	0	A	3140386	A	A	3140386	3	1	11	1	0	0	0	0	1	0	0	0	18294	1087	38	1	1297	1	ZSCAN10	16	3140386	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	2374411	3140386	87214367	116	2817											
MON1B	22879	broad.mit.edu	37	chr16	77229463	77229463	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aggccccctacagcagagagGaggagcggcagcggctgtcg	9	3	17	12	3	0	1	0	0	0	1	1	4	0	3	2	5	4	3	2	5	1	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr16:77229463G>C	uc002fez.2	+	5	1657	c.1327G>C	c.(1327-1329)GAG>CAG	p.E443Q	MON1B_uc010vnf.1_Missense_Mutation_p.E334Q|MON1B_uc010vng.1_Missense_Mutation_p.E297Q|MON1B_uc002ffa.2_Missense_Mutation_p.E323Q	NM_014940	NP_055755	Q7L1V2	MON1B_HUMAN	MON1 homolog B	443							protein binding				0						CAGCAGAGAGGAGGAGCGGCA	0.632													5	24					0	0	0	0	C	77229463	C	C	77229463	3	2	11	1	0	0	0	0	1	0	0	0	9752	1175	41	2	1341	2	MON1B	16	77229463	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	74089077	77229463	13125290	117	2818											
SLC38A8	146167	broad.mit.edu	37	chr16	84050761	84050761	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacctccccaggaagagcaCgatggggtagacagttacga	12	6	12	11	2	1	2	1	0	0	2	2	5	2	3	3	3	2	3	3	3	3	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr16:84050761C>T	uc002fhg.1	-	7	937	c.937G>A	c.(937-939)GTG>ATG	p.V313M		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	313	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0						AGGAAGAGCACGATGGGGTAG	0.522													10	56					0	0	0	0	T	84050761	T	T	84050761	3	4	11	1	0	0	0	0	1	0	0	0	14674	536	19	1	386	1	SLC38A8	16	84050761	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	6821298	84050761	6303992	118	2819											
PRDM7	11105	broad.mit.edu	37	chr16	90133294	90133294	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgtttactctgttctcctCtgaaggccatccaaggaggt	7	13	11	10	0	3	1	0	1	3	0	5	2	4	2	3	4	1	2	3	4	3	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr16:90133294C>T	uc010cje.2	-	4	346	c.326G>A	c.(325-327)AGA>AAA	p.R109K	PRDM7_uc010cjf.2_Intron|PRDM7_uc010cjh.1_RNA	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1	109						chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTGTTCTCCTCTGAAGGCCAT	0.373													46	281					0	0	0	0	T	90133294	T	T	90133294	3	4	11	1	0	0	0	0	1	0	0	0	12523	913	32	2	1180	2	PRDM7	16	90133294	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	6082533	90133294	221459	119	2820											
RPH3AL	9501	broad.mit.edu	37	chr17	169309	169309	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgttccccatcacattccGcctcatggtctccagccgct	5	10	7	19	3	3	0	2	0	1	0	6	0	5	0	7	1	1	2	7	1	0	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:169309G>A	uc002frd.1	-	3	297	c.253C>T	c.(253-255)CGG>TGG	p.R85W	RPH3AL_uc010vpy.1_Missense_Mutation_p.R85W|RPH3AL_uc002fre.1_Missense_Mutation_p.R85W|RPH3AL_uc002frf.1_Missense_Mutation_p.R85W|RPH3AL_uc010cjl.1_Missense_Mutation_p.R85W	NM_006987	NP_008918	Q9UNE2	RPH3L_HUMAN	rabphilin 3A-like (without C2 domains)	85	RabBD.			R -> Q (in Ref. 4; AAH05153).	exocytosis|intracellular protein transport	transport vesicle membrane	cytoskeletal protein binding|Rab GTPase binding|zinc ion binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.023)|all cancers(1;4.96e-06)|Epithelial(1;2.86e-05)|BRCA - Breast invasive adenocarcinoma(1;0.00453)|OV - Ovarian serous cystadenocarcinoma(1;0.0716)|LUAD - Lung adenocarcinoma(1115;0.102)|COAD - Colon adenocarcinoma(4;0.107)		ATCACATTCCGCCTCATGGTC	0.632													5	40					0	0	0	0	A	169309	A	A	169309	3	1	11	1	0	0	0	0	1	0	0	0	13617	1086	38	1	718	1	RPH3AL	17	169309	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08		169309	81025901	120	2821											
TOM1L2	146691	broad.mit.edu	37	chr17	17788024	17788024	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctttcctcttcagctccTcatatatgtgcacaacgccg	7	12	5	17	2	3	0	2	0	1	0	5	0	5	0	5	0	3	2	5	0	3	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:17788024T>A	uc002grz.3	-	5	582	c.425A>T	c.(424-426)GAG>GTG	p.E142V	TOM1L2_uc002gry.3_Missense_Mutation_p.E92V|TOM1L2_uc010vwy.1_Missense_Mutation_p.E142V|TOM1L2_uc010cpr.2_Intron|TOM1L2_uc010vwz.1_Intron|TOM1L2_uc010vxa.1_Intron|TOM1L2_uc010vxb.1_Missense_Mutation_p.E92V	NM_001082968	NP_001076437	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 isoform 3	142	VHS.				intracellular protein transport	intracellular					0	all_neural(463;0.228)					CTTCAGCTCCTCATATATGTG	0.517													23	207					0	0	0	0	A	17788024	A	A	17788024	3	1	11	1	0	0	0	0	1	0	0	0	16419	1551	54	5	1142	5	TOM1L2	17	17788024	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	17618715	17788024	63407186	121	2822											
ABHD15	116236	broad.mit.edu	37	chr17	27893561	27893561	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggccccgaacacaaggtcCtaccacccagtccagggcca	10	3	10	18	2	0	0	0	0	0	0	2	1	2	0	7	3	2	0	7	3	3	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:27893561C>G	uc002hed.1	-	1	488	c.424G>C	c.(424-426)GGA>CGA	p.G142R	TP53I13_uc002hee.2_5'Flank	NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	142						extracellular region	carboxylesterase activity				0						ACACAAGGTCCTACCACCCAG	0.687													3	28					0	0	0	0	G	27893561	G	G	27893561	3	3	11	1	0	0	0	0	1	0	0	0	81	690	24	4	990	4	ABHD15	17	27893561	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	10105537	27893561	53301649	122	2823											
WIPF2	147179	broad.mit.edu	37	chr17	38421105	38421105	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtcgagagggacctcctgCtccacccccagtcaaaccac	9	6	9	17	1	1	1	1	0	0	1	4	3	3	2	6	2	2	1	6	2	1	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:38421105C>T	uc002hug.1	+	5	917	c.677C>T	c.(676-678)GCT>GTT	p.A226V	WIPF2_uc002huh.1_Missense_Mutation_p.A76V|WIPF2_uc010cww.1_Missense_Mutation_p.A76V|WIPF2_uc002hui.1_Missense_Mutation_p.A226V|WIPF2_uc010cwx.1_Intron|WIPF2_uc010cwy.1_Missense_Mutation_p.A226V	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	226						cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GGACCTCCTGCTCCACCCCCA	0.607										HNSCC(43;0.11)			29	213					0	0	0	0	T	38421105	T	T	38421105	3	4	11	1	0	0	0	0	1	0	0	0	17436	797	28	4	691	4	WIPF2	17	38421105	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	10527544	38421105	42774105	123	2824											
KIAA1267	284058	broad.mit.edu	37	chr17	44109631	44109631	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggttggcactgcccagctGgggggttgtccggccgtctg	2	9	19	11	2	1	0	0	0	1	0	2	0	2	0	3	7	2	4	3	7	0	2	rs147378906		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:44109631G>A	uc002ikb.2	-	13	2957	c.2872C>T	c.(2872-2874)CAG>TAG	p.Q958*	KIAA1267_uc002ikc.2_Nonsense_Mutation_p.Q958*|KIAA1267_uc002ikd.2_Nonsense_Mutation_p.Q958*|KIAA1267_uc010dav.2_Nonsense_Mutation_p.Q957*|KIAA1267_uc010wkb.1_Nonsense_Mutation_p.Q289*|KIAA1267_uc010wkc.1_Nonsense_Mutation_p.Q226*	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	958						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				CTGCCCAGCTGGGGGGTTGTC	0.577													11	76					0	0	0	0	A	44109631	A	A	44109631	4	1	11	1	0	0	0	0	0	1	0	0	8258	1357	47	4	453	4	KIAA1267	17	44109631	Nonsense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	5688526	44109631	37085579	124	2825											
ANKFN1	162282	broad.mit.edu	37	chr17	54230890	54230890	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catggaggcgtctctaaccaGggtaggaaaacaatagttct	13	9	11	8	1	2	0	0	0	2	0	3	2	2	2	1	4	2	2	1	4	6	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:54230890G>A	uc002iun.1	+	1	55	c.20G>A	c.(19-21)AGG>AAG	p.R7K		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	7										large_intestine(1)|ovary(1)	2						TCTCTAACCAGGGTAGGAAAA	0.488													11	112					0	0	0	0	A	54230890	A	A	54230890	3	1	11	1	0	0	0	0	1	0	0	0	625	1014	35	4	22	4	ANKFN1	17	54230890	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	10121259	54230890	26964320	125	2826											
TRIM37	4591	broad.mit.edu	37	chr17	57181722	57181722	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcatcccgcaatttctccaTacaaatgaaacatcggaaaa	16	9	5	11	2	1	1	0	1	1	0	4	2	2	2	2	1	3	2	2	1	6	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:57181722T>C	uc002iwy.3	-	2	499	c.55A>G	c.(55-57)ATG>GTG	p.M19V	TRIM37_uc002iwz.3_Missense_Mutation_p.M19V|TRIM37_uc002ixa.3_5'UTR|TRIM37_uc010woc.1_Intron|uc002ixb.2_5'Flank	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	19	RING-type; degenerate.					perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					AATTTCTCCATACAAATGAAA	0.408									Mulibrey_Nanism				15	92					0	0	0	0	C	57181722	C	C	57181722	3	2	11	1	0	0	0	0	1	0	0	0	16578	1406	49	5	2939	5	TRIM37	17	57181722	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	2950832	57181722	24013488	126	2827											
MED13	9969	broad.mit.edu	37	chr17	60050211	60050211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aactggctgaagagagaggaGcattcgaagtatatcctgtg	13	9	13	6	1	0	3	0	1	0	2	2	6	1	4	1	2	2	3	1	2	5	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:60050211G>A	uc002izo.2	-	17	3921	c.3844C>T	c.(3844-3846)CTC>TTC	p.L1282F		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1282	LXXLL motif 2.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						AGAGAGAGGAGCATTCGAAGT	0.373													60	249					0	0	0	0	A	60050211	A	A	60050211	3	1	11	1	0	0	0	0	1	0	0	0	9483	971	34	4	2736	4	MED13	17	60050211	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	2868489	60050211	21144999	127	2828											
TLK2	11011	broad.mit.edu	37	chr17	60678092	60678092	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaattaatgtcggagaaagAggcccggtccattatcatgc	13	9	10	9	2	1	2	1	0	0	2	3	3	2	2	2	3	1	0	2	3	4	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:60678092A>G	uc010ddp.2	+	19	1965	c.1697A>G	c.(1696-1698)GAG>GGG	p.E566G	TLK2_uc002izx.3_Missense_Mutation_p.E392G|TLK2_uc002izz.3_Missense_Mutation_p.E544G|TLK2_uc002jaa.3_Missense_Mutation_p.E512G|TLK2_uc010wpd.1_Missense_Mutation_p.E512G	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	566	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						TCGGAGAAAGAGGCCCGGTCC	0.368													19	97					0	0	0	0	G	60678092	G	G	60678092	3	3	11	1	0	0	0	0	1	0	0	0	16010	304	11	5	1697	5	TLK2	17	60678092	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	627881	60678092	20517118	128	2829											
ABCA10	10349	broad.mit.edu	37	chr17	67197795	67197795	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaaataatggagaatcccCatggccatctttatctaatt	15	12	6	8	0	2	1	0	0	2	1	3	3	3	1	3	2	0	0	3	2	6	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:67197795C>T	uc010dfa.1	-	11	1900	c.1021G>A	c.(1021-1023)GGG>AGG	p.G341R	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_5'UTR|ABCA10_uc010dfc.1_Intron	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	341					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GGAGAATCCCCATGGCCATCT	0.313													6	75					0	0	0	0	T	67197795	T	T	67197795	3	4	11	1	0	0	0	0	1	0	0	0	29	594	21	4	3730	4	ABCA10	17	67197795	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	6519703	67197795	13997415	129	2830											
RFNG	5986	broad.mit.edu	37	chr17	80006664	80006664	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccgtgtctgggtacagaaGacaatggatagacttaaacc	13	9	11	8	1	1	3	0	0	1	3	2	4	2	4	2	2	2	1	2	2	6	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:80006664G>A	uc002kdj.2	-	8	942	c.934C>T	c.(934-936)CTT>TTT	p.L312F	RFNG_uc002kdh.2_Missense_Mutation_p.L97F	NM_002917	NP_002908	Q9Y644	RFNG_HUMAN	radical fringe	312	Lumenal (Potential).				cell differentiation|nervous system development|organ morphogenesis|pattern specification process	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GGGTACAGAAGACAATGGATA	0.408													7	81					0	0	0	0	A	80006664	A	A	80006664	3	1	11	1	0	0	0	0	1	0	0	0	13317	942	33	2	65	2	RFNG	17	80006664	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	12808869	80006664	1188546	130	2831											
CDH19	28513	broad.mit.edu	37	chr18	64239419	64239419	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggaattcccaacataaaaCgcagcagtaaataacagttc	18	7	7	9	1	0	0	0	0	0	0	2	2	1	1	1	1	4	4	1	1	7	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr18:64239419C>T	uc002lkc.1	-	2	161	c.23G>A	c.(22-24)CGT>CAT	p.R8H	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.R8H|CDH19_uc002lkd.2_Missense_Mutation_p.R8H	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	8					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CAACATAAAACGCAGCAGTAA	0.398													4	99					0	0	0	0	T	64239419	T	T	64239419	3	4	11	1	0	0	0	0	1	0	0	0	3119	536	19	1	2339	1	CDH19	18	64239419	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08		64239419	13837829	131	2832											
ZNF791	163049	broad.mit.edu	37	chr19	12734621	12734621	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgtgatgcaggaaacattCaagaacctggcatctatagg	14	9	11	7	0	2	2	1	1	1	1	2	4	2	3	1	3	3	2	1	3	5	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:12734621C>G	uc002mua.2	+	2	273	c.111C>G	c.(109-111)TTC>TTG	p.F37L	ZNF791_uc010xml.1_Missense_Mutation_p.F5L|ZNF791_uc010dyu.1_5'UTR|ZNF791_uc010xmm.1_Intron	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AGGAAACATTCAAGAACCTGG	0.323													16	108					0	0	0	0	G	12734621	G	G	12734621	3	3	11	1	0	0	0	0	1	0	0	0	18230	825	29	2	117	2	ZNF791	19	12734621	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08		12734621	46394362	132	2833											
CPAMD8	27151	broad.mit.edu	37	chr19	17038893	17038893	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccagggtgaaggcctcgctgTagctctcgtccacctccatc	6	9	10	16	2	1	1	0	1	1	0	6	1	3	1	5	2	1	3	5	2	2	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:17038893T>C	uc002nfb.2	-	25	3469	c.3437A>G	c.(3436-3438)TAC>TGC	p.Y1146C		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1099						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GGCCTCGCTGTAGCTCTCGTC	0.637													4	91					0	0	0	0	C	17038893	C	C	17038893	3	2	11	1	0	0	0	0	1	0	0	0	3810	1638	57	5	2433	5	CPAMD8	19	17038893	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	4304272	17038893	42090090	133	2834											
ZNF208	7757	broad.mit.edu	37	chr19	22155688	22155688	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttgtagggtttctctccAgtatgaattctcttatgttc	7	19	7	8	0	2	1	0	1	2	0	6	1	3	1	1	1	0	4	1	1	4	7			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:22155688A>T	uc002nqp.2	-	5	1997	c.1848T>A	c.(1846-1848)ACT>ACA	p.T616T	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTTTCTCTCCAGTATGAATTC	0.373													12	111					0	0	0	0	T	22155688	T	T	22155688	2	4	11	1	0	0	0	0	0	0	0	1	17833	175	7	5		5	ZNF208	19	22155688	Silent	SNP	A	TCGA-BA-5556-01A-01D-1512-08	5116795	22155688	36973295	134	2835											
ZNF181	339318	broad.mit.edu	37	chr19	35231761	35231761	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagtgtttacaaatacaatAtatttagaagcacctttcat	16	14	4	7	0	1	1	1	0	0	1	1	1	1	1	1	0	3	2	1	0	8	8			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:35231761A>G	uc002nvu.3	+	4	938	c.475A>G	c.(475-477)ATA>GTA	p.I159V	ZNF181_uc010xsa.1_Missense_Mutation_p.I158V|ZNF181_uc010xsb.1_Missense_Mutation_p.I158V|ZNF181_uc010xsc.1_Missense_Mutation_p.I94V	NM_001029997	NP_001025168	Q2M3W8	ZN181_HUMAN	zinc finger protein 181 isoform 1	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CAAATACAATATATTTAGAAG	0.373													23	104					0	0	0	0	G	35231761	G	G	35231761	3	3	11	1	0	0	0	0	1	0	0	0	17816	449	16	5	489	5	ZNF181	19	35231761	Missense_Mutation	SNP	A	TCGA-BA-5556-01A-01D-1512-08	13076073	35231761	23897222	135	2836											
SERTAD1	29950	broad.mit.edu	37	chr19	40928872	40928872	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatcctcagggcctggtttGaggccctcagaggctggtgc	5	9	14	13	0	2	2	2	1	0	1	3	2	3	2	4	5	1	2	4	5	0	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:40928872G>C	uc002ont.3	-	2	741	c.582C>G	c.(580-582)CTC>CTG	p.L194L		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	194					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCCTGGTTTGAGGCCCTCAG	0.582													6	26					0	0	0	0	C	40928872	C	C	40928872	2	2	11	1	0	0	0	0	0	0	0	1	14185	1277	45	2		2	SERTAD1	19	40928872	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08	5697111	40928872	18200111	136	2837											
SFRS16	11129	broad.mit.edu	37	chr19	45561107	45561107	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagaggaggaggagtcagcGgccgaggaggagagcaactc	12	2	18	9	2	1	2	1	0	0	2	2	8	1	6	2	6	3	1	2	6	1	0	rs143800882	byFrequency	TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:45561107G>A	uc002pak.2	+	7	662	c.564G>A	c.(562-564)GCG>GCA	p.A188A	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Silent_p.A126A|SFRS16_uc002pam.2_Silent_p.A188A|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	188					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AGGAGTCAGCGGCCGAGGAGG	0.612													12	95					0	0	0	0	A	45561107	A	A	45561107	2	1	11	1	0	0	0	0	0	0	0	1	14237	1103	39	1		1	SFRS16	19	45561107	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08	4632235	45561107	13567876	137	2838											
OPA3	80207	broad.mit.edu	37	chr19	46032622	46032622	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcccagcagctccgcgcccaGctcggcggctgcaccctcgt	4	5	12	20	5	0	0	0	0	0	0	3	0	1	0	4	2	4	5	4	2	0	0			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:46032622G>A	uc002pcj.3	-	2	335	c.235C>T	c.(235-237)CTG>TTG	p.L79L		NM_001017989	NP_001017989	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform a	79					response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		TCCGCGCCCAGCTCGGCGGCT	0.627													10	82					0	0	0	0	A	46032622	A	A	46032622	2	1	11	1	0	0	0	0	0	0	0	1	10926	962	34	4		4	OPA3	19	46032622	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08	471515	46032622	13096361	138	2839											
IGFL2	147920	broad.mit.edu	37	chr19	46664118	46664118	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagtgccactcatctccCatctccagtaaatgtgaaag	11	10	6	14	0	3	1	1	1	2	0	6	1	4	1	4	0	1	1	4	0	3	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:46664118C>T	uc010xxv.1	+	3	357	c.321C>T	c.(319-321)CCC>CCT	p.P107P	IGFL2_uc002peb.2_Silent_p.P118P	NM_001135113	NP_001128585	Q6UWQ7	IGFL2_HUMAN	IGF-like family member 2 isoform b	107						extracellular region	protein binding				0		Ovarian(192;0.0908)|all_neural(266;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(486;0.031)|Epithelial(262;0.247)		ACTCATCTCCCATCTCCAGTA	0.532													5	129					0	0	0	0	T	46664118	T	T	46664118	2	4	11	1	0	0	0	0	0	0	0	1	7626	581	21	4		4	IGFL2	19	46664118	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	631496	46664118	12464865	139	2840											
DHX34	9704	broad.mit.edu	37	chr19	47865870	47865870	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtctgcttccgcctctatGccgaatcggactatgatgcc	7	11	10	13	3	2	1	0	1	2	0	4	4	3	2	4	1	3	1	4	1	3	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:47865870G>A	uc010xyn.1	+	6	1854	c.1513G>A	c.(1513-1515)GCC>ACC	p.A505T	DHX34_uc010elc.1_Missense_Mutation_p.A420T	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	505	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CCGCCTCTATGCCGAATCGGA	0.657													9	51					0	0	0	0	A	47865870	A	A	47865870	3	1	11	1	0	0	0	0	1	0	0	0	4529	1319	46	4	1531	4	DHX34	19	47865870	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	1201752	47865870	11263113	140	2841											
RBL1	5933	broad.mit.edu	37	chr20	35684633	35684633	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttttagtattttcataaTgttttccacaggattacgca	10	18	5	8	1	1	0	1	0	0	0	3	1	3	1	2	1	1	3	2	1	4	9			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr20:35684633T>A	uc002xgi.2	-	10	1358	c.1279A>T	c.(1279-1281)ATT>TTT	p.I427F	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.I427F|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	427	Domain A.|Pocket; binds T and E1A.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				ATTTTCATAATGTTTTCCACA	0.348													13	51					0	0	0	0	A	35684633	A	A	35684633	3	1	11	1	0	0	0	0	1	0	0	0	13174	1464	51	5	1988	5	RBL1	20	35684633	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08		35684633	27340887	141	2842											
SLC12A5	57468	broad.mit.edu	37	chr20	44676687	44676687	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggctcgctatgccctcttaCgcctggaggaagggccccca	6	7	12	16	3	1	0	0	0	1	0	2	2	1	2	4	4	2	2	4	4	3	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr20:44676687C>T	uc010zxl.1	+	16	2120	c.2044C>T	c.(2044-2046)CGC>TGC	p.R682C	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.R659C	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	682					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGCCCTCTTACGCCTGGAGGA	0.597													3	24					0	0	0	0	T	44676687	T	T	44676687	3	4	11	1	0	0	0	0	1	0	0	0	14451	536	19	1	2162	1	SLC12A5	20	44676687	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	8992054	44676687	18348833	142	2843											
ZNF334	55713	broad.mit.edu	37	chr20	45131097	45131097	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcctgcattcactgcatTcatagggtctctctccagta	7	16	6	12	0	4	0	2	0	2	0	7	0	5	0	2	1	2	3	2	1	2	6			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr20:45131097T>A	uc002xsc.2	-	5	1065	c.881A>T	c.(880-882)GAA>GTA	p.E294V	ZNF334_uc002xsa.2_Missense_Mutation_p.E317V|ZNF334_uc002xsb.2_Missense_Mutation_p.E256V|ZNF334_uc002xsd.2_Missense_Mutation_p.E256V|ZNF334_uc010ghl.2_Missense_Mutation_p.E293V	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	294	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				TTCACTGCATTCATAGGGTCT	0.423													52	241					0	0	0	0	A	45131097	A	A	45131097	3	1	11	1	0	0	0	0	1	0	0	0	17918	1783	62	5	1165	5	ZNF334	20	45131097	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	454410	45131097	17894423	143	2844											
TPTE	7179	broad.mit.edu	37	chr21	10934054	10934054	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttactgtagagtggggacaTtatgatcatcaatcatgatt	12	14	9	6	0	3	3	3	2	0	1	3	4	3	4	0	2	1	1	0	2	4	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:10934054T>A	uc002yip.1	-	16	1291	c.923A>T	c.(922-924)AAT>ATT	p.N308I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.N290I|TPTE_uc002yir.1_Missense_Mutation_p.N270I|TPTE_uc010gkv.1_Missense_Mutation_p.N170I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	308	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGTGGGGACATTATGATCATC	0.299													20	438					0	0	0	0	A	10934054	A	A	10934054	3	1	11	1	0	0	0	0	1	0	0	0	16497	1493	52	5	768	5	TPTE	21	10934054	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08		10934054	37195841	144	2845											
APP	351	broad.mit.edu	37	chr21	27269978	27269978	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tccgtcttgatatttgtcaaCccagaacctgtattacatca	11	14	5	11	1	3	2	2	1	1	1	4	2	4	2	3	0	3	1	3	0	5	5	rs141559720	byFrequency	TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:27269978C>T	uc002ylz.2	-	16	2171	c.1971G>A	c.(1969-1971)GGG>GGA	p.G657G	APP_uc011acg.1_Silent_p.G165G|APP_uc010glk.2_Silent_p.G633G|APP_uc002yma.2_Silent_p.G638G|APP_uc011ach.1_Silent_p.G601G|APP_uc002ymb.2_Silent_p.G582G|APP_uc010glj.2_Silent_p.G526G|APP_uc011aci.1_Silent_p.G547G	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	657	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				TATTTGTCAACCCAGAACCTG	0.358													31	237					0	0	0	0	T	27269978	T	T	27269978	2	4	11	1	0	0	0	0	0	0	0	1	815	494	18	4		4	APP	21	27269978	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08	16335924	27269978	20859917	145	2846											
GRIK1	2897	broad.mit.edu	37	chr21	30959875	30959875	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgactttctcccgcacgtagGtgatggtaagaggagccact	9	10	12	10	2	1	3	0	2	1	1	2	4	1	4	2	3	1	3	2	3	2	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:30959875G>T	uc002yno.1	-	12	2068	c.1604C>A	c.(1603-1605)ACC>AAC	p.T535N	GRIK1_uc002ynn.2_Missense_Mutation_p.T520N|GRIK1_uc011acs.1_Missense_Mutation_p.T535N|GRIK1_uc011act.1_Missense_Mutation_p.T396N|GRIK1_uc010glq.1_Missense_Mutation_p.T378N	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	535	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CCGCACGTAGGTGATGGTAAG	0.483													3	48					0.004672	0.00486872	1	0	T	30959875	T	T	30959875	3	4	11	1	0	0	0	0	1	0	0	0	6812	1261	44	4	1336	4	GRIK1	21	30959875	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	3689897	30959875	17170020	146	2847											
DSCR3	10311	broad.mit.edu	37	chr21	38610786	38610786	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgttgacaaacacgccatgaTacgtctcatacagaactttg	13	11	7	10	2	1	3	1	2	1	1	2	3	1	3	1	0	4	1	1	0	4	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:38610786T>C	uc002ywf.1	-	4	565	c.326A>G	c.(325-327)TAT>TGT	p.Y109C	DSCR3_uc010gnm.1_RNA|DSCR3_uc010gnn.1_Missense_Mutation_p.Y67C|DSCR3_uc010gnl.2_Missense_Mutation_p.Y109C|DSCR3_uc011aeg.1_Intron|DSCR3_uc011aeh.1_Intron	NM_006052	NP_006043	O14972	DSCR3_HUMAN	Down syndrome critical region protein 3	109					vacuolar transport	nucleus|retromer complex					0						CACGCCATGATACGTCTCATA	0.448													7	162					0	0	0	0	C	38610786	C	C	38610786	3	2	11	1	0	0	0	0	1	0	0	0	4793	1406	49	5	591	5	DSCR3	21	38610786	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	7650911	38610786	9519109	147	2848											
B3GALT5	10317	broad.mit.edu	37	chr21	41032541	41032541	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttctggttctgggggctCtttgtttgtattttagcatg	3	19	12	7	0	3	0	0	0	3	0	3	0	3	0	1	3	1	5	1	3	2	7			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:41032541C>A	uc002yyb.1	+	5	647	c.55C>A	c.(55-57)CTT>ATT	p.L19I	B3GALT5_uc002yye.2_Missense_Mutation_p.L19I|B3GALT5_uc002yyi.1_Missense_Mutation_p.L19I|B3GALT5_uc002yyj.1_Missense_Mutation_p.L19I|B3GALT5_uc002yyk.1_Missense_Mutation_p.L19I|B3GALT5_uc002yyl.1_Missense_Mutation_p.L19I|B3GALT5_uc002yym.1_Missense_Mutation_p.L19I	NM_033173	NP_149363	Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta	19	Helical; Signal-anchor for type II membrane protein; (Potential).				protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1		Prostate(19;2.55e-06)				TCTGGGGGCTCTTTGTTTGTA	0.398													28	220					1.08312e-15	1.27653e-15	1	0	A	41032541	A	A	41032541	3	1	11	1	0	0	0	0	1	0	0	0	1252	913	32	2	57	2	B3GALT5	21	41032541	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	2421755	41032541	7097354	148	2849											
S100B	6285	broad.mit.edu	37	chr21	48022218	48022218	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgggaaagctcattgttGatgagctccttcagttcgga	11	12	11	7	1	2	2	2	2	0	0	4	4	3	4	1	2	2	4	1	2	2	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:48022218G>C	uc002zju.1	-	2	222	c.111C>G	c.(109-111)ATC>ATG	p.I37M	S100B_uc002zjv.1_Missense_Mutation_p.I37M	NM_006272	NP_006263	P04271	S100B_HUMAN	S100 calcium-binding protein, beta	37	EF-hand 1.				axonogenesis|cell proliferation|central nervous system development|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular region|nucleus|perinuclear region of cytoplasm|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|RAGE receptor binding|S100 beta binding|tau protein binding|zinc ion binding				0	Breast(49;0.247)	Lung NSC(3;0.245)		OV - Ovarian serous cystadenocarcinoma(3;1.84e-06)|Epithelial(3;4.45e-06)|all cancers(3;2.07e-05)|Colorectal(79;0.241)		GCTCATTGTTGATGAGCTCCT	0.443													11	76					0	0	0	0	C	48022218	C	C	48022218	3	2	11	1	0	0	0	0	1	0	0	0	13853	1280	45	2	175	2	S100B	21	48022218	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	6989677	48022218	107677	149	2850											
DNAJB7	150353	broad.mit.edu	37	chr22	41257198	41257198	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaacccaagatatacctccCtcatcattgtccacgaaagt	13	10	5	13	1	2	1	2	0	0	1	4	2	4	1	4	0	2	1	4	0	5	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr22:41257198C>T	uc003azj.2	-	1	933	c.801G>A	c.(799-801)GAG>GAA	p.E267E	XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azh.2_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_5'Flank|XPNPEP3_uc003azg.1_Intron|XPNPEP3_uc003azf.1_Intron|XPNPEP3_uc010gyh.1_5'Flank	NM_145174	NP_660157	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	267					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)	1						ATATACCTCCCTCATCATTGT	0.423													23	136					0	0	0	0	T	41257198	T	T	41257198	2	4	11	1	0	0	0	0	0	0	0	1	4647	680	24	4		4	DNAJB7	22	41257198	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08		41257198	10047368	150	2851											
CYB5R3	1727	broad.mit.edu	37	chr22	43032788	43032788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggtgatggctggcgtggagCgctggaacagcttcatgagc	7	8	18	8	2	1	2	1	2	0	0	1	4	1	4	0	5	4	3	0	5	1	1	rs140159332		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr22:43032788C>T	uc003bcz.2	-	2	170	c.86G>A	c.(85-87)CGC>CAC	p.R29H	CYB5R3_uc010gzc.1_5'UTR|CYB5R3_uc003bcw.2_Missense_Mutation_p.R19H|CYB5R3_uc011aps.1_Missense_Mutation_p.R62H|CYB5R3_uc003bcy.2_Missense_Mutation_p.R6H|CYB5R3_uc003bcx.2_Missense_Mutation_p.R6H	NM_000398	NP_000389	P00387	NB5R3_HUMAN	cytochrome b5 reductase 3 isoform m	29				QRSTP -> RWPRA (in Ref. 10; AAA52307).|R -> G (in Ref. 1; AAA59900).	blood circulation|cholesterol biosynthetic process|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|hemoglobin complex|mitochondrial outer membrane	cytochrome-b5 reductase activity			skin(1)	1					NADH(DB00157)	TGGCGTGGAGCGCTGGAACAG	0.642													7	23					0	0	0	0	T	43032788	T	T	43032788	3	4	11	1	0	0	0	0	1	0	0	0	4145	768	27	1	851	1	CYB5R3	22	43032788	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	1775590	43032788	8271778	151	2852											
FRMPD4	9758	broad.mit.edu	37	chrX	12701661	12701661	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattaaagtccaatcctgtCaaagtacgcttctctgagga	13	11	8	9	1	2	2	1	1	1	1	5	3	4	3	2	1	1	2	2	1	5	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:12701661C>A	uc004cuz.1	+	6	1034	c.528C>A	c.(526-528)GTC>GTA	p.V176V	FRMPD4_uc011mij.1_Silent_p.V168V	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	176					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CCAATCCTGTCAAAGTACGCT	0.418													14	90					2.31682e-05	2.46629e-05	1	0	A	12701661	A	A	12701661	2	1	11	1	0	0	0	0	0	0	0	1	6093	813	29	2		2	FRMPD4	23	12701661	Silent	SNP	C	TCGA-BA-5556-01A-01D-1512-08		12701661	142568899	152	2853											
PHKA2	5256	broad.mit.edu	37	chrX	18972501	18972501	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caggcatccttctgctcatgGctggctgacagcagccccgt	6	9	11	15	1	2	1	1	1	1	0	3	1	3	1	3	3	3	5	3	3	0	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:18972501G>T	uc004cyv.3	-	2	538	c.108C>A	c.(106-108)AGC>AGA	p.S36R	PHKA2_uc010nfh.1_RNA|PHKA2_uc010nfi.1_5'UTR	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	36					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					TCTGCTCATGGCTGGCTGACA	0.562													25	107					4.26978e-12	4.85871e-12	1	0	T	18972501	T	T	18972501	3	4	11	1	0	0	0	0	1	0	0	0	11899	1194	42	4	3727	4	PHKA2	23	18972501	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	6270840	18972501	136298059	153	2854											
RPS6KA3	6197	broad.mit.edu	37	chrX	20211697	20211697	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagtagaatttgacatcttcTtctgtgaacatcacctaaaa	15	13	5	8	0	4	3	1	2	3	1	4	3	4	3	1	0	1	1	1	0	6	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:20211697T>A	uc004czu.2	-	7	501	c.501A>T	c.(499-501)GAA>GAT	p.E167D	RPS6KA3_uc011mjk.1_Missense_Mutation_p.E138D|RPS6KA3_uc004czv.2_Missense_Mutation_p.E155D|RPS6KA3_uc011mjl.1_Missense_Mutation_p.E139D|RPS6KA3_uc011mjm.1_Missense_Mutation_p.E139D	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	167	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						TGACATCTTCTTCTGTGAACA	0.294													6	78					0	0	0	0	A	20211697	A	A	20211697	3	1	11	1	0	0	0	0	1	0	0	0	13717	1606	56	5	1785	5	RPS6KA3	23	20211697	Missense_Mutation	SNP	T	TCGA-BA-5556-01A-01D-1512-08	1239196	20211697	135058863	154	2855											
MED12	9968	broad.mit.edu	37	chrX	70349995	70349995	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatgcagctcatttgctaTccacatcgactgctggacaa	10	11	7	13	1	2	0	2	0	0	0	4	2	3	1	1	1	4	4	1	1	2	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:70349995T>C	uc004dyy.2	+	28	4177	c.3978T>C	c.(3976-3978)TAT>TAC	p.Y1326Y	MED12_uc011mpq.1_Silent_p.Y1326Y|MED12_uc004dyz.2_Silent_p.Y1326Y|MED12_uc004dza.2_Silent_p.Y1173Y|MED12_uc010nla.2_5'UTR	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1326					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TCATTTGCTATCCACATCGAC	0.572													4	29					0	0	0	0	C	70349995	C	C	70349995	2	2	11	1	0	0	0	0	0	0	0	1	9481	1442	50	5		5	MED12	23	70349995	Silent	SNP	T	TCGA-BA-5556-01A-01D-1512-08	50138298	70349995	84920565	155	2856											
ATRX	546	broad.mit.edu	37	chrX	76814235	76814235	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ataagatggattccaagaagCgtcgaatataattactcgat	16	11	8	6	3	0	2	0	0	0	2	3	5	1	3	1	1	2	0	1	1	7	5			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:76814235C>T	uc004ecp.3	-	29	6641	c.6409G>A	c.(6409-6411)GCT>ACT	p.A2137T	ATRX_uc004ecq.3_Missense_Mutation_p.A2099T|ATRX_uc004eco.3_Missense_Mutation_p.A1922T	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2137	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTCCAAGAAGCGTCGAATATA	0.353			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						28	170					0	0	0	0	T	76814235	T	T	76814235	3	4	11	1	0	0	0	0	1	0	0	0	1210	768	27	1	1097	1	ATRX	23	76814235	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	6464240	76814235	78456325	156	2857											
ATRX	546	broad.mit.edu	37	chrX	76939409	76939409	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccaaagcacaaggtttttCtccttttcgtgcttttgttt	6	20	6	9	1	1	0	0	0	1	0	4	0	2	0	2	1	2	4	2	1	2	8			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:76939409C>T	uc004ecp.3	-	9	1571	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K	ATRX_uc004ecq.3_Missense_Mutation_p.E409K|ATRX_uc004eco.3_Missense_Mutation_p.E232K|ATRX_uc004ecr.2_Missense_Mutation_p.E408K|ATRX_uc010nlx.1_Missense_Mutation_p.E447K|ATRX_uc010nly.1_Missense_Mutation_p.E392K	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	447					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CAAGGTTTTTCTCCTTTTCGT	0.363			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						60	379					0	0	0	0	T	76939409	T	T	76939409	3	4	11	1	0	0	0	0	1	0	0	0	1210	922	32	2	6247	2	ATRX	23	76939409	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	125174	76939409	78331151	157	2858											
PGAM4	441531	broad.mit.edu	37	chrX	77224509	77224509	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atgggaataccagtcggcagGttcagctccatgatagcctc	10	9	11	11	1	1	1	1	1	0	0	4	2	2	2	3	3	3	3	3	3	3	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:77224509G>A	uc004ecy.1	-	1	627	c.627C>T	c.(625-627)AAC>AAT	p.N209N	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	209					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						CAGTCGGCAGGTTCAGCTCCA	0.527													11	232					0	0	0	0	A	77224509	A	A	77224509	2	1	11	1	0	0	0	0	0	0	0	1	11830	1252	44	4		4	PGAM4	23	77224509	Silent	SNP	G	TCGA-BA-5556-01A-01D-1512-08	285100	77224509	78046051	158	2859											
GPRASP1	9737	broad.mit.edu	37	chrX	101909693	101909693	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gatcccaatagcaggtccagGtttaggtctaagaaagaagt	14	9	11	7	0	1	2	0	0	1	2	3	3	3	2	2	3	1	2	2	3	6	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:101909693G>T	uc004ejj.3	+	5	1653	c.852G>T	c.(850-852)AGG>AGT	p.R284S	GPRASP1_uc004eji.3_Missense_Mutation_p.R284S|GPRASP1_uc010nod.2_Missense_Mutation_p.R284S	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	284						cytoplasm	protein binding			ovary(1)|lung(1)	2						GCAGGTCCAGGTTTAGGTCTA	0.483													19	241					1.56452e-12	1.79061e-12	1	0	T	101909693	T	T	101909693	3	4	11	1	0	0	0	0	1	0	0	0	6761	1252	44	4	854	4	GPRASP1	23	101909693	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	24685184	101909693	53360867	159	2860											
RAB40A	142684	broad.mit.edu	37	chrX	102755663	102755663	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaagtcataggcctggtCggggctgcccggggcgctca	6	6	17	12	3	2	0	2	0	0	0	3	1	2	1	2	7	1	2	2	7	2	1			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:102755663C>A	uc004ekk.2	-	3	364	c.22G>T	c.(22-24)GAC>TAC	p.D8Y		NM_080879	NP_543155	Q8WXH6	RB40A_HUMAN	RAB40A, member RAS oncogene family	8					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0						TAGGCCTGGTCGGGGCTGCCC	0.667													12	81					5.16669e-11	5.81252e-11	1	0	A	102755663	A	A	102755663	3	1	11	1	0	0	0	0	1	0	0	0	13004	884	31	3	815	3	RAB40A	23	102755663	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	845970	102755663	52514897	160	2861											
WDR44	54521	broad.mit.edu	37	chrX	117582909	117582909	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctctgctgacttcactggaGcaatcaaagtgtttgttaat	10	15	8	8	0	3	1	2	1	1	0	4	2	3	2	0	1	2	4	0	1	3	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:117582909G>A	uc004eqn.2	+	20	3126	c.2701G>A	c.(2701-2703)GCA>ACA	p.A901T	WDR44_uc004eqo.2_Missense_Mutation_p.A893T|WDR44_uc011mtr.1_Missense_Mutation_p.A812T|WDR44_uc010nqi.2_3'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	901	WD 7.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						CTTCACTGGAGCAATCAAAGT	0.254													16	91					0	0	0	0	A	117582909	A	A	117582909	3	1	11	1	0	0	0	0	1	0	0	0	17364	971	34	4	2779	4	WDR44	23	117582909	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	14827246	117582909	37687651	161	2862											
CT47B1	643311	broad.mit.edu	37	chrX	120008795	120008795	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggtcggttcctctgcggccgGttcctctgtggcctcctctg	0	13	13	15	3	3	0	0	0	3	0	7	0	6	0	5	5	1	2	5	5	0	2			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:120008795G>A	uc011muc.1	-	1	985	c.730C>T	c.(730-732)CCG>TCG	p.P244S		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	244											0						TCTGCGGCCGGTtcctctgtg	0.547													34	197					0	0	0	0	A	120008795	A	A	120008795	3	1	11	1	0	0	0	0	1	0	0	0	4006	1261	44	4	177	4	CT47B1	23	120008795	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	2425886	120008795	35261765	162	2863											
PNMA5	114824	broad.mit.edu	37	chrX	152159412	152159412	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcagaaacctaaactgaGaggctctaaagtcctcttta	13	11	7	10	0	3	2	0	1	3	2	4	3	4	2	2	1	3	2	2	1	6	4			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:152159412G>T	uc010ntw.2	-	3	1070	c.731C>A	c.(730-732)TCT>TAT	p.S244Y	PNMA5_uc004fha.3_Missense_Mutation_p.S244Y|PNMA5_uc010ntx.2_Missense_Mutation_p.S244Y|PNMA5_uc004fgy.3_Missense_Mutation_p.S244Y	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	244					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CCTAAACTGAGAGGCTCTAAA	0.522													30	184					3.00307e-07	3.32183e-07	1	0	T	152159412	T	T	152159412	3	4	11	1	0	0	0	0	1	0	0	0	12211	942	33	2	619	2	PNMA5	23	152159412	Missense_Mutation	SNP	G	TCGA-BA-5556-01A-01D-1512-08	32150617	152159412	3111148	163	2864											
PNMA3	29944	broad.mit.edu	37	chrX	152226640	152226640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggctcaagaaaacggaaaCgccacacattctgctatagc	15	6	9	11	2	2	1	1	0	1	1	2	3	2	2	1	2	4	2	1	2	6	3			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:152226640C>T	uc004fhc.2	+	2	1564	c.1228C>T	c.(1228-1230)CGC>TGC	p.R410C	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	410	Arg-rich.				apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAAACGGAAACGCCACACATT	0.597													16	137					0	0	0	0	T	152226640	T	T	152226640	3	4	11	1	0	0	0	0	1	0	0	0	12210	536	19	1	1230	1	PNMA3	23	152226640	Missense_Mutation	SNP	C	TCGA-BA-5556-01A-01D-1512-08	67228	152226640	3043920	164	2865											
KAZ	23254	broad.mit.edu	37	chr1	15361331	15361331	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtatgccacactggagagcCgcgaggagcagctccgagac	10	5	14	12	3	0	2	0	0	0	2	1	6	1	3	3	2	4	3	3	2	1	1			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr1:15361331C>T	uc001avm.3	+	3	786	c.505C>T	c.(505-507)CGC>TGC	p.R169C	KAZ_uc009vog.1_Missense_Mutation_p.R169C|KAZ_uc010obj.1_Missense_Mutation_p.R169C|KAZ_uc001avo.2_Missense_Mutation_p.R163C|KAZ_uc001avp.2_Missense_Mutation_p.R75C|KAZ_uc001avq.2_Missense_Mutation_p.R75C|KAZ_uc001avr.2_Missense_Mutation_p.R72C	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	169	Potential.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						ACTGGAGAGCCGCGAGGAGCA	0.617													6	54					0	0	0	0	T	15361331	T	T	15361331	3	4	12	1	0	0	0	0	1	0	0	0	8027	652	23	1	727	1	KAZ	1	15361331	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08		15361331	233889290	1	2866											
HSPG2	3339	broad.mit.edu	37	chr1	22186712	22186712	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcacactggggttacccaCgtaacctgggccacacctgt	8	9	10	14	1	0	0	0	0	0	0	0	0	0	0	4	3	3	3	4	3	2	3	rs143523507		TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr1:22186712C>T	uc001bfj.2	-	40	5012	c.4972G>A	c.(4972-4974)GTG>ATG	p.V1658M	HSPG2_uc009vqd.2_Missense_Mutation_p.V1659M	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	1658	Laminin EGF-like 11.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGGTTACCCACGTAACCTGGG	0.637													4	26					0	0	0	0	T	22186712	T	T	22186712	3	4	12	1	0	0	0	0	1	0	0	0	7469	536	19	1	8435	1	HSPG2	1	22186712	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	6825381	22186712	227063909	2	2867											
TGFB2	7042	broad.mit.edu	37	chr1	218609454	218609454	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcacaacagaccaaccggcgGaagaagcgtgctttggatgc	12	6	12	11	3	1	2	1	0	0	2	1	4	1	4	2	3	5	1	2	3	4	1			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr1:218609454G>A	uc001hlm.2	+	5	1550	c.897G>A	c.(895-897)CGG>CGA	p.R299R	TGFB2_uc001hln.2_Silent_p.R327R|TGFB2_uc010pue.1_RNA|TGFB2_uc001hlo.2_RNA	NM_003238	NP_003229	P61812	TGFB2_HUMAN	transforming growth factor, beta 2 isoform 2	299					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding				0				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		CCAACCGGCGGAAGAAGCGTG	0.433													6	70					0	0	0	0	A	218609454	A	A	218609454	2	1	12	1	0	0	0	0	0	0	0	1	15884	1161	41	2		2	TGFB2	1	218609454	Silent	SNP	G	TCGA-BA-5557-01A-01D-1512-08	196422742	218609454	30641167	3	2868											
OR2T33	391195	broad.mit.edu	37	chr1	248436658	248436658	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaacagcctgcaggagcccGtcagctgcacccaggagcca	11	3	11	16	1	1	0	1	0	0	0	1	2	1	2	4	2	7	3	4	2	1	0			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr1:248436658G>A	uc010pzi.1	-	1	459	c.459C>T	c.(457-459)GAC>GAT	p.D153D		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCAGGAGCCCGTCAGCTGCAC	0.587													9	118					0	0	0	0	A	248436658	A	A	248436658	2	1	12	1	0	0	0	0	0	0	0	1	11078	1136	40	1		1	OR2T33	1	248436658	Silent	SNP	G	TCGA-BA-5557-01A-01D-1512-08	29827204	248436658	813963	4	2869											
TTN	7273	broad.mit.edu	37	chr2	179659934	179659934	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagcaatggagacctaacAgacctgatgggggatgtgga	13	7	15	6	0	0	4	0	2	0	2	0	7	0	6	2	4	2	1	2	4	2	1			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr2:179659934A>G	uc010zfg.1	-	7	1184	c.960T>C	c.(958-960)TCT>TCC	p.S320S	TTN_uc010zfh.1_Silent_p.S320S|TTN_uc010zfi.1_Silent_p.S320S|TTN_uc010zfj.1_Silent_p.S320S|TTN_uc002unb.2_Silent_p.S320S|TTN_uc010frg.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	320							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGACCTAACAGACCTGATGG	0.547													10	60					0	0	0	0	G	179659934	G	G	179659934	2	3	12	1	0	0	0	0	0	0	0	1	16803	175	7	5		5	TTN	2	179659934	Silent	SNP	A	TCGA-BA-5557-01A-01D-1512-08		179659934	63539439	5	2870											
ARMC9	80210	broad.mit.edu	37	chr2	232081457	232081457	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcctttctatgcccttcCttttgttcccaaccctatgg	4	18	4	15	0	2	0	0	0	2	0	5	0	5	0	5	1	2	1	5	1	3	8			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr2:232081457C>T	uc002vrq.3	+	5	567	c.455C>T	c.(454-456)CCT>CTT	p.P152L	ARMC9_uc002vrp.3_Missense_Mutation_p.P152L	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	152							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		TATGCCCTTCCTTTTGTTCCC	0.463													9	141					0	0	0	0	T	232081457	T	T	232081457	3	4	12	1	0	0	0	0	1	0	0	0	960	681	24	4	469	4	ARMC9	2	232081457	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	52421523	232081457	11117916	6	2871											
NR2C2	7182	broad.mit.edu	37	chr3	15079580	15079580	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggagttctgtaacagcatGgcgaagctggatatagatgg	12	9	14	6	1	1	1	0	0	1	1	1	4	1	3	0	4	3	4	0	4	4	4			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr3:15079580G>A	uc003bzj.3	+	12	1663	c.1446G>A	c.(1444-1446)ATG>ATA	p.M482I	NR2C2_uc003bzi.2_Missense_Mutation_p.M501I	NM_003298	NP_003289	P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	482	Ligand-binding (By similarity).				cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						GTAACAGCATGGCGAAGCTGG	0.463													5	101					0	0	0	0	A	15079580	A	A	15079580	3	1	12	1	0	0	0	0	1	0	0	0	10677	1348	47	4	1549	4	NR2C2	3	15079580	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08		15079580	182942850	7	2872											
MORC1	27136	broad.mit.edu	37	chr3	108688549	108688549	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attttcagctttttgttcatCtgctctgggcactgctccag	5	17	8	11	0	4	0	2	0	2	0	5	0	5	0	1	1	3	5	1	1	0	5			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr3:108688549C>G	uc003dxl.2	-	26	2658	c.2571G>C	c.(2569-2571)CAG>CAC	p.Q857H	MORC1_uc011bhn.1_Missense_Mutation_p.Q836H	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	857					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TTTTGTTCATCTGCTCTGGGC	0.363													5	101					0	0	0	0	G	108688549	G	G	108688549	3	3	12	1	0	0	0	0	1	0	0	0	9754	912	32	2	395	2	MORC1	3	108688549	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	93608969	108688549	89333881	8	2873											
HCLS1	3059	broad.mit.edu	37	chr3	121363742	121363742	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgtctgagaagagtgcttctCcacctcggcaacatactcat	10	10	8	13	2	3	2	1	1	2	2	5	3	3	2	2	1	3	2	2	1	3	2			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr3:121363742C>G	uc003eeh.3	-	5	447	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	HCLS1_uc011bjj.1_Missense_Mutation_p.E108Q|HCLS1_uc011bjk.1_RNA|HCLS1_uc011bjl.1_Missense_Mutation_p.E108Q	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	108	Cortactin 1.				erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		GAGTGCTTCTCCACCTCGGCA	0.463													20	129					0	0	0	0	G	121363742	G	G	121363742	3	3	12	1	0	0	0	0	1	0	0	0	7034	864	30	2	1178	2	HCLS1	3	121363742	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	12675193	121363742	76658688	9	2874											
PLOD2	5352	broad.mit.edu	37	chr3	145788905	145788905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgatgaggacgaagagaaCgctgtcgttcaggggagtat	12	8	15	6	3	1	3	1	2	0	1	2	7	1	5	0	3	1	3	0	3	3	2			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr3:145788905C>T	uc003evs.1	-	18	2488	c.1982G>A	c.(1981-1983)CGT>CAT	p.R661H	PLOD2_uc003evq.1_Missense_Mutation_p.R342H|PLOD2_uc011bnm.1_Missense_Mutation_p.R627H|PLOD2_uc003evr.1_Missense_Mutation_p.R682H	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	661	Fe2OG dioxygenase.				protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	ACGAAGAGAACGCTGTCGTTC	0.348													6	34					0	0	0	0	T	145788905	T	T	145788905	3	4	12	1	0	0	0	0	1	0	0	0	12157	536	19	1	239	1	PLOD2	3	145788905	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	24425163	145788905	52233525	10	2875											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			4	50					0	0	0	0	A	178936082	A	A	178936082	3	1	12	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	33147177	178936082	19086348	11	2876											
SLC4A4	8671	broad.mit.edu	37	chr4	72425867	72425867	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcttctcccagcacgacCtcagcttcctggatgatgtc	7	11	7	16	1	3	1	1	1	2	0	6	3	4	2	4	1	2	2	4	1	0	2			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr4:72425867C>A	uc003hfy.2	+	23	3112	c.2995C>A	c.(2995-2997)CTC>ATC	p.L999I	SLC4A4_uc010iic.2_Missense_Mutation_p.L999I|SLC4A4_uc010iib.2_Missense_Mutation_p.L915I|SLC4A4_uc003hfz.2_Missense_Mutation_p.L999I|SLC4A4_uc003hgc.3_Missense_Mutation_p.L955I|SLC4A4_uc010iid.2_Missense_Mutation_p.L203I	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	999	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CCAGCACGACCTCAGCTTCCT	0.348													24	109					3.99451e-17	4.35765e-17	1	0	A	72425867	A	A	72425867	3	1	12	1	0	0	0	0	1	0	0	0	14720	681	24	4	3202	4	SLC4A4	4	72425867	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08		72425867	118728409	12	2877											
ERAP2	64167	broad.mit.edu	37	chr5	96222495	96222495	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttcatcaggggtcaaggTgagactgagttctaacgttc	10	11	11	9	1	4	2	3	2	1	1	5	3	4	2	0	3	1	2	0	3	2	4			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr5:96222495T>A	uc003kmq.2	+	4	1559	c.849_splice	c.e4+2	p.K283_splice	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Splice_Site_p.K283_splice|ERAP2_uc003kmr.2_Splice_Site|ERAP2_uc003kms.2_Intron|ERAP2_uc003kmu.2_Splice_Site	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2						antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		GGGGTCAAGGTGAGACTGAGT	0.378													12	77					0	0	0	0	A	96222495	A	A	96222495	5	1	12	1	0	0	0	0	0	0	1	0	5228	1710	59	5	861	5	ERAP2	5	96222495	Splice_Site	SNP	T	TCGA-BA-5557-01A-01D-1512-08		96222495	84692765	13	2878											
PCDHB13	56123	broad.mit.edu	37	chr5	140595010	140595010	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taacacagctcaatatgaccGtgctgatcgccgatgtcaat	12	10	8	11	3	2	2	2	2	0	0	3	3	2	2	2	0	3	2	2	0	4	2			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr5:140595010G>A	uc003lja.1	+	1	1502	c.1315G>A	c.(1315-1317)GTG>ATG	p.V439M		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	439	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAATATGACCGTGCTGATCGC	0.547													18	102					0	0	0	0	A	140595010	A	A	140595010	3	1	12	1	0	0	0	0	1	0	0	0	11592	1145	40	1	1317	1	PCDHB13	5	140595010	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	44372515	140595010	40320250	14	2879											
PAPOLB	56903	broad.mit.edu	37	chr7	4899722	4899722	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacctgttgcaaggaaaattCagtagcctgtatgttagcca	12	11	9	9	0	1	0	1	0	0	0	1	1	1	1	3	1	3	5	3	1	6	5			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr7:4899722C>G	uc003snk.2	-	1	1904	c.1720G>C	c.(1720-1722)GAA>CAA	p.E574Q	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	573					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		AAGGAAAATTCAGTAGCCTGT	0.458													5	53					0	0	0	0	G	4899722	G	G	4899722	3	3	12	1	0	0	0	0	1	0	0	0	11484	835	29	2	197	2	PAPOLB	7	4899722	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08		4899722	154238941	15	2880											
PRKRIP1	79706	broad.mit.edu	37	chr7	102040012	102040012	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggttcaagtgctggggccGgcagtggagagttccacgtg	7	8	17	9	2	1	1	1	0	0	1	2	2	2	1	2	5	1	4	2	5	1	2			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr7:102040012G>A	uc003uzh.2	+	3	278	c.223G>A	c.(223-225)GGC>AGC	p.G75S	PRKRIP1_uc003uzf.2_Missense_Mutation_p.G24S|PRKRIP1_uc003uzg.2_Missense_Mutation_p.G24S|PRKRIP1_uc011kkq.1_Missense_Mutation_p.G18S|PRKRIP1_uc011kkr.1_Missense_Mutation_p.G75S	NM_024653	NP_078929	Q9H875	PKRI1_HUMAN	PRKR interacting protein 1 (IL11 inducible)	75	Required for RNA-binding (By similarity).					nucleolus				ovary(1)	1						TGCTGGGGCCGGCAGTGGAGA	0.512													19	115					0	0	0	0	A	102040012	A	A	102040012	3	1	12	1	0	0	0	0	1	0	0	0	12587	1116	39	1	233	1	PRKRIP1	7	102040012	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	97140290	102040012	57098651	16	2881											
CALD1	800	broad.mit.edu	37	chr7	134644737	134644737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatttcagggaacaaaaagcGcaaaacctacaaagccggca	19	4	8	10	2	1	0	1	0	0	0	1	1	1	1	2	2	5	2	2	2	8	2			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr7:134644737G>A	uc003vrz.2	+	12	2533	c.2074G>A	c.(2074-2076)GCA>ACA	p.A692T	CALD1_uc003vry.2_Missense_Mutation_p.A437T|CALD1_uc003vsa.2_Missense_Mutation_p.A463T|CALD1_uc003vsb.2_Missense_Mutation_p.A437T|CALD1_uc010lmm.2_Missense_Mutation_p.A462T|CALD1_uc011kpt.1_Missense_Mutation_p.A211T|CALD1_uc003vsc.2_Missense_Mutation_p.A457T|CALD1_uc003vsd.2_Missense_Mutation_p.A431T|CALD1_uc011kpu.1_Missense_Mutation_p.A442T|CALD1_uc011kpv.1_Missense_Mutation_p.A301T|CALD1_uc003vse.2_Missense_Mutation_p.A555T|CALD1_uc010lmn.2_RNA	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	692					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						AACAAAAAGCGCAAAACCTAC	0.418													3	40					0	0	0	0	A	134644737	A	A	134644737	3	1	12	1	0	0	0	0	1	0	0	0	2593	1087	38	1	2169	1	CALD1	7	134644737	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	32604725	134644737	24493926	17	2882											
IKBKB	3551	broad.mit.edu	37	chr8	42147786	42147786	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgccaaggaggagatctcCggaaggtgaggctcccacgg	10	5	15	11	2	1	2	0	1	1	1	3	5	2	4	3	6	1	1	3	6	2	0			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr8:42147786C>G	uc003xow.1	+	4	490	c.313C>G	c.(313-315)CGG>GGG	p.R105G	IKBKB_uc003xov.2_Missense_Mutation_p.R105G|IKBKB_uc010lxh.1_Intron|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Intron|IKBKB_uc003xox.1_5'UTR|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.R103G|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.R46G	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	105	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	AGGAGATCTCCGGAAGGTGAG	0.612													4	13					0	0	0	0	G	42147786	G	G	42147786	3	3	12	1	0	0	0	0	1	0	0	0	7650	643	23	3	323	3	IKBKB	8	42147786	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08		42147786	104216236	18	2883											
CDKN2A	1029	broad.mit.edu	37	chr9	21971110	21971110	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccctcccgggcagcgtcgTgcacgggtcgggtgagagtg	5	6	18	12	5	0	1	0	1	0	1	3	2	1	1	2	3	3	2	2	3	0	0			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr9:21971110T>C	uc003zpk.2	-	2	460	c.248A>G	c.(247-249)CAC>CGC	p.H83R	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.A138A	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	83	ANK 3.		H -> N (in a lung tumor).|H -> Y (in a pancreas and a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.H83Y(27)|p.?(13)|p.H83fs*2(2)|p.H83P(2)|p.H83N(1)|p.V82fs*62(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.D84fs*36(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)|p.H83Q(1)|p.H83R(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GGCAGCGTCGTGCACGGGTCG	0.741		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	14					0	0	0	0	C	21971110	C	C	21971110	3	2	12	1	0	0	0	0	1	0	0	0	3176	1696	59	5	230	5	CDKN2A	9	21971110	Missense_Mutation	SNP	T	TCGA-BA-5557-01A-01D-1512-08		21971110	119242321	19	2884											
MYST4	23522	broad.mit.edu	37	chr10	76789551	76789551	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggatgtcccatcagtttcaGatcattcacagcaagtcgta	11	12	8	10	1	4	1	4	0	0	1	6	2	5	2	1	1	1	3	1	1	2	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr10:76789551G>C	uc001jwn.1	+	18	5462	c.4969G>C	c.(4969-4971)GAT>CAT	p.D1657H	MYST4_uc001jwo.1_Missense_Mutation_p.D1365H|MYST4_uc001jwp.1_Missense_Mutation_p.D1474H	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1657	Ser-rich.|Interaction with RUNX1 and RUNX2.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					ATCAGTTTCAGATCATTCACA	0.473			T	CREBBP	AML								5	100					0	0	0	0	C	76789551	C	C	76789551	3	2	12	1	0	0	0	0	1	0	0	0	10158	942	33	2	5031	2	MYST4	10	76789551	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08		76789551	58745196	20	2885											
OR52E2	119678	broad.mit.edu	37	chr11	5080386	5080386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaagtatagagggaatgaCgaaaattaaagccctcacaa	20	6	9	6	1	1	3	1	1	0	2	1	5	1	4	1	1	1	1	1	1	10	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr11:5080386C>T	uc010qyw.1	-	1	472	c.472G>A	c.(472-474)GTC>ATC	p.V158I		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GAGGGAATGACGAAAATTAAA	0.453													4	20					0	0	0	0	T	5080386	T	T	5080386	3	4	12	1	0	0	0	0	1	0	0	0	11169	536	19	1	508	1	OR52E2	11	5080386	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08		5080386	129926130	21	2886											
CHST1	8534	broad.mit.edu	37	chr11	45671747	45671747	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgcggaaggtctcgctgcGcgaagccagaatgccgcggg	7	5	17	12	7	1	1	0	0	1	1	3	3	1	2	2	3	3	1	2	3	3	0			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr11:45671747G>A	uc001mys.1	-	4	1398	c.727C>T	c.(727-729)CGC>TGC	p.R243C		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	243	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		GTCTCGCTGCGCGAAGCCAGA	0.657													4	66					0	0	0	0	A	45671747	A	A	45671747	3	1	12	1	0	0	0	0	1	0	0	0	3412	1087	38	1	512	1	CHST1	11	45671747	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	40591361	45671747	89334769	22	2887											
OR8J3	81168	broad.mit.edu	37	chr11	55904529	55904529	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgtatccttagaatggacaaAacaatattgaaataagatac	19	10	6	6	1	0	3	0	1	0	2	1	4	1	4	1	1	2	1	1	1	10	6			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr11:55904529A>T	uc010riz.1	-	1	666	c.666T>A	c.(664-666)GTT>GTA	p.V222V		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					GAATGGACAAAACAATATTGA	0.373													5	89					0	0	0	0	T	55904529	T	T	55904529	2	4	12	1	0	0	0	0	0	0	0	1	11296	1	1	5		5	OR8J3	11	55904529	Silent	SNP	A	TCGA-BA-5557-01A-01D-1512-08	10232782	55904529	79101987	23	2888											
BBS1	582	broad.mit.edu	37	chr11	66278499	66278499	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccagcaatgaggccaattcGaagtggttggatgcgcacta	11	9	12	9	2	0	1	0	1	0	0	2	3	1	2	2	3	2	3	2	3	4	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr11:66278499G>A	uc001oij.1	+	2	75	c.63G>A	c.(61-63)TCG>TCA	p.S21S	BBS1_uc001oii.1_Silent_p.S58S|BBS1_uc010rpf.1_RNA|BBS1_uc010rpg.1_Silent_p.S21S|BBS1_uc001oik.1_5'UTR|BBS1_uc001oil.1_Silent_p.S21S	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	21					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						AGGCCAATTCGAAGTGGTTGG	0.517									Bardet-Biedl_syndrome				19	210					0	0	0	0	A	66278499	A	A	66278499	2	1	12	1	0	0	0	0	0	0	0	1	1337	1045	37	1		1	BBS1	11	66278499	Silent	SNP	G	TCGA-BA-5557-01A-01D-1512-08	10373970	66278499	68728017	24	2889											
IGSF9B	22997	broad.mit.edu	37	chr11	133791120	133791120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggcctctgccttggccaCgctgtacttcttgctgctga	3	13	10	15	2	2	1	0	1	2	0	3	1	2	1	3	2	4	4	3	2	1	4			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr11:133791120C>T	uc001qgx.3	-	18	2731	c.2500G>A	c.(2500-2502)GTG>ATG	p.V834M		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	834	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GCCTTGGCCACGCTGTACTTC	0.657													3	40					0	0	0	0	T	133791120	T	T	133791120	3	4	12	1	0	0	0	0	1	0	0	0	7645	536	19	1	1557	1	IGSF9B	11	133791120	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	67512621	133791120	1215396	25	2890											
KCNA6	3742	broad.mit.edu	37	chr12	4920108	4920108	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatcatgaacatcattgacTtggtggctatcttcccctac	10	13	6	12	0	3	2	2	2	1	0	4	2	4	2	2	2	2	1	2	2	3	5			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr12:4920108T>C	uc001qng.2	+	1	1767	c.901T>C	c.(901-903)TTG>CTG	p.L301L		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	301	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CATCATTGACTTGGTGGCTAT	0.582										HNSCC(72;0.22)			23	63					0	0	0	0	C	4920108	C	C	4920108	2	2	12	1	0	0	0	0	0	0	0	1	8046	1606	56	5		5	KCNA6	12	4920108	Silent	SNP	T	TCGA-BA-5557-01A-01D-1512-08		4920108	128931787	26	2891											
PZP	5858	broad.mit.edu	37	chr12	9318713	9318713	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcaccgtttcagggactggCcctgaactttgttcattatt	7	14	9	11	2	2	1	2	1	0	0	2	2	2	2	2	2	1	3	2	2	2	5			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr12:9318713C>A	uc001qvl.2	-	18	2222	c.2193G>T	c.(2191-2193)GGG>GGT	p.G731G	PZP_uc009zgl.2_Silent_p.G600G|PZP_uc010sgo.1_RNA|PZP_uc009zgm.1_Silent_p.G63G	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						CAGGGACTGGCCCTGAACTTT	0.428													14	104					6.31663e-08	6.68819e-08	1	0	A	9318713	A	A	9318713	2	1	12	1	0	0	0	0	0	0	0	1	12934	726	26	4		4	PZP	12	9318713	Silent	SNP	C	TCGA-BA-5557-01A-01D-1512-08	4398605	9318713	124533182	27	2892											
TMEM120B	144404	broad.mit.edu	37	chr12	122211410	122211410	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagaggaaccacctggatCtcacagtgggtgagtagctg	10	7	16	8	0	1	2	1	1	1	1	2	5	1	4	2	4	2	2	2	4	2	1			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr12:122211410C>G	uc001ubc.3	+	9	907	c.763C>G	c.(763-765)CTC>GTC	p.L255V	TMEM120B_uc009zxh.2_Missense_Mutation_p.L255V|TMEM120B_uc001uba.1_5'Flank	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	255						integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		CCACCTGGATCTCACAGTGGG	0.652											OREG0022206	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	18					0	0	0	0	G	122211410	G	G	122211410	3	3	12	1	0	0	0	0	1	0	0	0	16100	913	32	2	797	2	TMEM120B	12	122211410	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	112892697	122211410	11640485	28	2893											
PITPNM2	57605	broad.mit.edu	37	chr12	123482002	123482002	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttggcgatggtgttagcatCgcccttcttggagctggggt	4	13	16	8	2	1	0	0	0	1	0	2	2	1	1	1	5	2	4	1	5	1	4			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr12:123482002C>T	uc001uej.1	-	10	1481	c.1342G>A	c.(1342-1344)GAT>AAT	p.D448N	PITPNM2_uc001uek.1_Missense_Mutation_p.D448N	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	448					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GTGTTAGCATCGCCCTTCTTG	0.682													12	89					0	0	0	0	T	123482002	T	T	123482002	3	4	12	1	0	0	0	0	1	0	0	0	12006	884	31	1	2771	1	PITPNM2	12	123482002	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	1270592	123482002	10369893	29	2894											
GOLGA6A	342096	broad.mit.edu	37	chr15	74368258	74368258	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctgtgtcacgtgtgcgttCagcagcgcccgctcctttat	5	12	10	14	4	2	0	2	0	0	0	3	0	3	0	3	0	3	3	3	0	1	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr15:74368258C>T	uc002axa.1	-	8	674	c.633G>A	c.(631-633)CTG>CTA	p.L211L		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	211	Potential.										0						CGTGTGCGTTCAGCAGCGCCC	0.582													5	76					0	0	0	0	T	74368258	T	T	74368258	2	4	12	1	0	0	0	0	0	0	0	1	6594	813	29	2		2	GOLGA6A	15	74368258	Silent	SNP	C	TCGA-BA-5557-01A-01D-1512-08		74368258	28163134	30	2895											
ABCC11	85320	broad.mit.edu	37	chr16	48211016	48211016	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtgtaaaggagcttccgaGacacacatcttgtttttgaa	12	13	9	7	1	1	2	0	1	1	1	2	4	2	3	1	1	1	3	1	1	3	5			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr16:48211016G>A	uc002eff.1	-	24	3707	c.3357C>T	c.(3355-3357)GTC>GTT	p.V1119V	ABCC11_uc002efg.1_Silent_p.V1119V|ABCC11_uc002efh.1_Silent_p.V1119V|ABCC11_uc010cbg.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	1119	Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GAGCTTCCGAGACACACATCT	0.483									Cerumen_Type				5	54					0	0	0	0	A	48211016	A	A	48211016	2	1	12	1	0	0	0	0	0	0	0	1	51	929	33	2		2	ABCC11	16	48211016	Silent	SNP	G	TCGA-BA-5557-01A-01D-1512-08		48211016	42143737	31	2896											
HIC1	3090	broad.mit.edu	37	chr17	1960080	1960080	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttcttgtgcgacgtgatcatCgtggtgcagaacgccctctt	6	13	11	11	4	3	2	1	1	2	1	4	3	3	2	1	1	3	1	1	1	1	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr17:1960080C>G	uc010cjy.2	+	2	153	c.153C>G	c.(151-153)ATC>ATG	p.I51M	HIC1_uc002fty.3_Missense_Mutation_p.I32M|HIC1_uc002ftz.3_Missense_Mutation_p.I32M	NM_001098202	NP_001091672	Q14526	HIC1_HUMAN	hypermethylated in cancer 1 isoform 2	51	BTB.				multicellular organismal development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)	1				READ - Rectum adenocarcinoma(1115;0.236)		ACGTGATCATCGTGGTGCAGA	0.632													5	30					0	0	0	0	G	1960080	G	G	1960080	3	3	12	1	0	0	0	0	1	0	0	0	7140	874	31	3	159	3	HIC1	17	1960080	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08		1960080	79235130	32	2897											
ZNF232	7775	broad.mit.edu	37	chr17	5012303	5012303	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcccagagattccttcttCtcccatggctcttcctgtgc	4	14	7	16	0	3	1	0	0	3	1	7	2	6	1	4	1	1	2	4	1	0	4			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr17:5012303C>T	uc002gas.2	-	4	1216	c.462G>A	c.(460-462)GAG>GAA	p.E154E	ZNF232_uc002gar.1_Silent_p.E181E|ZNF232_uc002gat.2_Silent_p.E181E|ZNF232_uc010vsv.1_3'UTR	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	154					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						ATTCCTTCTTCTCCCATGGCT	0.498													12	150					0	0	0	0	T	5012303	T	T	5012303	2	4	12	1	0	0	0	0	0	0	0	1	17852	912	32	2		2	ZNF232	17	5012303	Silent	SNP	C	TCGA-BA-5557-01A-01D-1512-08	3052223	5012303	76182907	33	2898											
TP53	7157	broad.mit.edu	37	chr17	7578247	7578247	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccaaatactccacacgcAaatttccttccactcggata	13	10	3	15	2	0	0	0	0	0	0	5	1	4	1	4	1	1	1	4	1	4	4			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr17:7578247A>T	uc002gim.2	-	6	796	c.602T>A	c.(601-603)TTG>TAG	p.L201*	TP53_uc002gig.1_Nonsense_Mutation_p.L201*|TP53_uc002gih.2_Nonsense_Mutation_p.L201*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.L69*|TP53_uc010cng.1_Nonsense_Mutation_p.L69*|TP53_uc002gii.1_Nonsense_Mutation_p.L69*|TP53_uc010cnh.1_Nonsense_Mutation_p.L201*|TP53_uc010cni.1_Nonsense_Mutation_p.L201*|TP53_uc002gij.2_Nonsense_Mutation_p.L201*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.L108*|TP53_uc002gio.2_Nonsense_Mutation_p.L69*|TP53_uc010vug.1_Nonsense_Mutation_p.L162*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	201	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> S (in a sporadic cancer; somatic mutation).|LR -> FC (in a sporadic cancer; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L201F(7)|p.L201fs*46(4)|p.K164_P219del(1)|p.E198_L201>V(1)|p.N200fs*4(1)|p.L201P(1)|p.L201S(1)|p.E198fs*7(1)|p.L201fs*8(1)|p.P191fs*6(1)|p.L201_R202>FC(1)|p.L201L(1)|p.G199fs*42(1)|p.L201*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCCACACGCAAATTTCCTTC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	43					0	0	0	0	T	7578247	T	T	7578247	4	4	12	1	0	0	0	0	0	1	0	0	16448	131	5	5	692	5	TP53	17	7578247	Nonsense_Mutation	SNP	A	TCGA-BA-5557-01A-01D-1512-08	2565944	7578247	73616963	34	2899											
NF1	4763	broad.mit.edu	37	chr17	29557872	29557872	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctataggaataagatggtAgaatacctgacagactgggt	14	11	11	5	0	1	4	0	1	1	3	1	5	1	5	1	3	1	1	1	3	7	6			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr17:29557872A>G	uc002hgg.2	+	24	3459	c.3126A>G	c.(3124-3126)GTA>GTG	p.V1042V	NF1_uc002hgh.2_Silent_p.V1042V|NF1_uc010csn.1_Silent_p.V902V|NF1_uc002hgi.1_Silent_p.V75V	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1042					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATAAGATGGTAGAATACCTGA	0.368			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			3	34					0	0	0	0	G	29557872	G	G	29557872	2	3	12	1	0	0	0	0	0	0	0	1	10410	407	15	5		5	NF1	17	29557872	Silent	SNP	A	TCGA-BA-5557-01A-01D-1512-08	21979625	29557872	51637338	35	2900											
PITPNC1	26207	broad.mit.edu	37	chr17	65548417	65548417	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttgtccccaaaatattttAtgtgacagagaaggcttgga	12	13	10	6	0	0	2	0	1	0	1	1	4	1	3	2	2	0	2	2	2	5	5			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr17:65548417A>G	uc002jgc.2	+	3	589	c.242A>G	c.(241-243)TAT>TGT	p.Y81C	PITPNC1_uc002jgb.2_Missense_Mutation_p.Y81C	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	81					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			AAAATATTTTATGTGACAGAG	0.413													8	63					0	0	0	0	G	65548417	G	G	65548417	3	3	12	1	0	0	0	0	1	0	0	0	12004	449	16	5	252	5	PITPNC1	17	65548417	Missense_Mutation	SNP	A	TCGA-BA-5557-01A-01D-1512-08	35990545	65548417	15646793	36	2901											
PLEKHG2	64857	broad.mit.edu	37	chr19	39913429	39913429	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccaggtgcctggcgacagcGaaaccctcacattccaagcc	10	5	9	17	2	1	0	1	0	0	0	2	2	2	0	5	2	4	0	5	2	2	1			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr19:39913429G>A	uc010xuz.1	+	18	2060	c.1735G>A	c.(1735-1737)GAA>AAA	p.E579K	PLEKHG2_uc010xuy.1_Missense_Mutation_p.E520K|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.E357K	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	579					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TGGCGACAGCGAAACCCTCAC	0.587													4	57					0	0	0	0	A	39913429	A	A	39913429	3	1	12	1	0	0	0	0	1	0	0	0	12124	1059	37	1	1801	1	PLEKHG2	19	39913429	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08		39913429	19215554	37	2902											
FGF21	26291	broad.mit.edu	37	chr19	49261276	49261276	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccgaagcccacggcctcccGctgcacctgccagggaacaa	9	4	10	18	3	0	0	0	0	0	0	2	2	2	1	6	2	4	2	6	2	3	0			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr19:49261276G>A	uc002pkn.1	+	4	1001	c.429G>A	c.(427-429)CCG>CCA	p.P143P	FUT1_uc002pkk.2_5'Flank|FUT1_uc002pkm.1_5'Flank|FGF21_uc002pko.1_Silent_p.P143P	NM_019113	NP_061986	Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21 precursor	143					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		ACGGCCTCCCGCTGCACCTGC	0.652													21	89					0	0	0	0	A	49261276	A	A	49261276	2	1	12	1	0	0	0	0	0	0	0	1	5882	1074	38	1		1	FGF21	19	49261276	Silent	SNP	G	TCGA-BA-5557-01A-01D-1512-08	9347847	49261276	9867707	38	2903											
PPP1R12C	54776	broad.mit.edu	37	chr19	55623923	55623923	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccccgtcactgttgacggcGgcgatgttggccccgtggct	3	10	14	14	5	1	1	1	1	0	0	2	2	2	1	4	4	0	3	4	4	0	2			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr19:55623923G>A	uc002qix.2	-	3	499	c.483C>T	c.(481-483)GCC>GCT	p.A161A	PPP1R12C_uc010yfs.1_Silent_p.A87A|PPP1R12C_uc002qiy.2_Silent_p.A161A	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	161	ANK 2.					cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		TGTTGACGGCGGCGATGTTGG	0.731													10	20					0	0	0	0	A	55623923	A	A	55623923	2	1	12	1	0	0	0	0	0	0	0	1	12416	1103	39	1		1	PPP1R12C	19	55623923	Silent	SNP	G	TCGA-BA-5557-01A-01D-1512-08	6362647	55623923	3505060	39	2904											
C19orf51	352909	broad.mit.edu	37	chr19	55670503	55670503	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggctgagccagaacctctGagagtgaacctggagactca	12	6	13	10	0	2	5	1	3	1	3	2	8	2	5	3	2	3	1	3	2	2	0			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr19:55670503G>A	uc002qji.1	-	12	1587	c.1553C>T	c.(1552-1554)TCA>TTA	p.S518L	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Missense_Mutation_p.S333L|C19orf51_uc002qjj.1_Missense_Mutation_p.S565L|C19orf51_uc002qjk.1_Missense_Mutation_p.S464L|C19orf51_uc002qjl.1_Missense_Mutation_p.S585L			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	518											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CAGAACCTCTGAGAGTGAACC	0.627													8	47					0	0	0	0	A	55670503	A	A	55670503	3	1	12	1	0	0	0	0	1	0	0	0	1942	1294	45	2	76	2	C19orf51	19	55670503	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	46580	55670503	3458480	40	2905											
NLRP4	147945	broad.mit.edu	37	chr19	56369450	56369450	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agagactcttgttcgtcatcGacagcttcgaagagctgcag	10	10	11	10	3	2	2	1	0	1	2	5	5	2	2	0	0	3	4	0	0	1	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr19:56369450G>A	uc002qmd.3	+	3	1113	c.691G>A	c.(691-693)GAC>AAC	p.D231N	NLRP4_uc002qmf.2_Missense_Mutation_p.D156N|NLRP4_uc010etf.2_Missense_Mutation_p.D62N	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	231	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GTTCGTCATCGACAGCTTCGA	0.547													7	92					0	0	0	0	A	56369450	A	A	56369450	3	1	12	1	0	0	0	0	1	0	0	0	10533	1058	37	1	697	1	NLRP4	19	56369450	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	698947	56369450	2759533	41	2906											
JAG1	182	broad.mit.edu	37	chr20	10626068	10626068	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaagtcattgaccaggtcGcgacacgtgcccccattgtg	9	9	11	12	3	1	2	1	1	0	1	2	3	1	2	3	1	1	0	3	1	2	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr20:10626068G>A	uc002wnw.2	-	16	2565	c.2049C>T	c.(2047-2049)CGC>CGT	p.R683R	JAG1_uc010gcd.1_Silent_p.R241R	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	683	EGF-like 12; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						TGACCAGGTCGCGACACGTGC	0.502									Alagille_Syndrome				18	89					0	0	0	0	A	10626068	A	A	10626068	2	1	12	1	0	0	0	0	0	0	0	1	7973	1074	38	1		1	JAG1	20	10626068	Silent	SNP	G	TCGA-BA-5557-01A-01D-1512-08		10626068	52399452	42	2907											
RALGAPA2	57186	broad.mit.edu	37	chr20	20696068	20696068	+	5'Flank	DEL	T	-	-																															tggcctcccatgttttgttgTttttttttttttttgacagt																										TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr20:20696068delT	uc002wrz.2	-						RALGAPA2_uc010zsg.1_5'Flank	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250						activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						TGttttgttgttttttttttt	0.005													---	---	---								-	20696068	-	-	20696068	6	5	12	0	1	1	0	1	0	0	0	0	13079	1740	60	0		0	RALGAPA2	20	20696068	5'Flank	DEL	T	TCGA-BA-5557-01A-01D-1512-08	10070000	20696068	42329452	43	2908											
PHF20	51230	broad.mit.edu	37	chr20	34519268	34519268	+	Missense_Mutation	SNP	G	C	C																															gaagagaactactcccatcaGaatgccaagaagatcgtggc																										TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr20:34519268G>C	uc002xek.1	+	15	2313	c.2202G>C	c.(2200-2202)CAG>CAC	p.Q734H		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	734					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					ACTCCCATCAGAATGCCAAGA	0.517													7	79					0	0	0	0	C	34519268	C	C	34519268	3	2	12	1	0	0	0	0	1	0	0	0	11886	933	33	2	2256	2	PHF20	20	34519268	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	13823200	34519268	28506252	44	2909	7	2									
PHF20	51230	broad.mit.edu	37	chr20	34519277	34519277	+	Silent	SNP	G	A	A																															tactcccatcagaatgccaaGaagatcgtggccacccacca																										TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr20:34519277G>A	uc002xek.1	+	15	2322	c.2211G>A	c.(2209-2211)AAG>AAA	p.K737K		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	737					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					AGAATGCCAAGAAGATCGTGG	0.522													7	81					0	0	0	0	A	34519277	A	A	34519277	2	1	12	1	0	0	0	0	0	0	0	1	11886	933	33	2		2	PHF20	20	34519277	Silent	SNP	G	TCGA-BA-5557-01A-01D-1512-08	9	34519277	28506243	45	2910	7	2									
C20orf85	128602	broad.mit.edu	37	chr20	56728608	56728608	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctttttcaggaaataccGtctgaaggctgaatcggaag	11	13	10	7	2	3	2	1	2	2	0	4	4	3	4	1	3	1	1	1	3	5	4	rs16984945	byFrequency	TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr20:56728608G>A	uc002xyv.2	+	2	115	c.77G>A	c.(76-78)CGT>CAT	p.R26H		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	26										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			AGGAAATACCGTCTGAAGGCT	0.483													21	173					0	0	0	0	A	56728608	A	A	56728608	3	1	12	1	0	0	0	0	1	0	0	0	2130	1145	40	1	83	1	C20orf85	20	56728608	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	22209331	56728608	6296912	46	2911											
TMPRSS15	5651	broad.mit.edu	37	chr21	19666941	19666941	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttatggttacactgtaaccGaatcaaggaatcctgtaaac	14	12	7	8	1	1	0	1	0	0	0	2	2	2	1	2	2	3	3	2	2	8	5	rs140721787		TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr21:19666941G>A	uc002ykw.2	-	20	2321	c.2290C>T	c.(2290-2292)CGG>TGG	p.R764W		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	764	Extracellular (Potential).|SRCR.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CACTGTAACCGAATCAAGGAA	0.284													7	101					0	0	0	0	A	19666941	A	A	19666941	3	1	12	1	0	0	0	0	1	0	0	0	16312	1057	37	1	793	1	TMPRSS15	21	19666941	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08		19666941	28462954	47	2912											
CCDC116	164592	broad.mit.edu	37	chr22	21989343	21989343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccgtggcgcccactgccgcGacggccgtcctctgttcccc	2	8	11	20	6	1	0	0	0	1	0	4	1	4	0	7	2	1	1	7	2	0	1			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr22:21989343G>A	uc002zve.2	+	4	1084	c.991G>A	c.(991-993)GAC>AAC	p.D331N	CCDC116_uc011aih.1_Missense_Mutation_p.D331N	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	331										ovary(1)|skin(1)	2	Colorectal(54;0.105)					CCACTGCCGCGACGGCCGTCC	0.657													6	41					0	0	0	0	A	21989343	A	A	21989343	3	1	12	1	0	0	0	0	1	0	0	0	2765	1058	37	1	1001	1	CCDC116	22	21989343	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08		21989343	29315223	48	2913											
CDC42EP1	11135	broad.mit.edu	37	chr22	37964720	37964720	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgggagagcctggacgaaGagtggagggcgccccaggca	9	3	18	11	2	0	2	0	0	0	2	0	6	0	4	4	5	1	1	4	5	1	0			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr22:37964720G>C	uc003asz.3	+	3	1472	c.1069G>C	c.(1069-1071)GAG>CAG	p.E357Q		NM_152243	NP_689449	Q00587	BORG5_HUMAN	CDC42 effector protein 1	357					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding				0	Melanoma(58;0.0574)					CCTGGACGAAGAGTGGAGGGC	0.647													4	3					0	0	0	0	C	37964720	C	C	37964720	3	2	12	1	0	0	0	0	1	0	0	0	3090	943	33	2	1075	2	CDC42EP1	22	37964720	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	15975377	37964720	13339846	49	2914											
DNAJB7	150353	broad.mit.edu	37	chr22	41257532	41257532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgaaccctgtgatgtatatCctgtatcatatgaagaaaat	15	13	7	6	0	1	4	1	3	0	1	2	4	2	4	2	0	1	2	2	0	8	4			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr22:41257532C>T	uc003azj.2	-	1	599	c.467G>A	c.(466-468)GGA>GAA	p.G156E	XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azh.2_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_5'Flank|XPNPEP3_uc003azg.1_Intron|XPNPEP3_uc003azf.1_Intron|XPNPEP3_uc010gyh.1_5'Flank	NM_145174	NP_660157	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	156					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)	1						TGATGTATATCCTGTATCATA	0.398													13	166					0	0	0	0	T	41257532	T	T	41257532	3	4	12	1	0	0	0	0	1	0	0	0	4647	855	30	2	466	2	DNAJB7	22	41257532	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	3292812	41257532	10047034	50	2915											
PLXNB2	23654	broad.mit.edu	37	chr22	50720062	50720062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggcgggggctgcacctccGggggctcacagtacaggtcg	5	6	18	12	3	1	0	1	0	0	0	3	0	2	0	2	6	2	4	2	6	1	1			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chr22:50720062G>A	uc003bkv.3	-	21	3561	c.3455C>T	c.(3454-3456)CCG>CTG	p.P1152L	PLXNB2_uc003bkt.1_5'UTR|PLXNB2_uc003bku.1_Missense_Mutation_p.P137L	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1152	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTGCACCTCCGGGGGCTCACA	0.677													3	38					0	0	0	0	A	50720062	A	A	50720062	3	1	12	1	0	0	0	0	1	0	0	0	12179	1116	39	1	2129	1	PLXNB2	22	50720062	Missense_Mutation	SNP	G	TCGA-BA-5557-01A-01D-1512-08	9462530	50720062	584504	51	2916											
CLCN4	1183	broad.mit.edu	37	chrX	10201608	10201608	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcaaaccaggaccccgaatCcatcatgtttaattagcaac	14	8	7	12	1	1	0	1	0	0	0	2	2	2	1	4	2	3	3	4	2	5	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chrX:10201608C>A	uc004csy.3	+	13	2697	c.2267C>A	c.(2266-2268)TCC>TAC	p.S756Y	CLCN4_uc011mid.1_Missense_Mutation_p.S662Y	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	756	Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GACCCCGAATCCATCATGTTT	0.358													6	86					0.00198382	0.0020405	1	0	A	10201608	A	A	10201608	3	1	12	1	0	0	0	0	1	0	0	0	3480	855	30	2	2309	2	CLCN4	23	10201608	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08		10201608	145068952	52	2917											
HUWE1	10075	broad.mit.edu	37	chrX	53570870	53570870	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtataatggcatcagcctCagcctccagctgccgaacag	10	9	9	13	1	2	0	2	0	0	0	3	1	3	0	4	1	5	3	4	1	3	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chrX:53570870C>T	uc004dsp.2	-	73	11713	c.11311G>A	c.(11311-11313)GAG>AAG	p.E3771K	HUWE1_uc004dsn.2_Missense_Mutation_p.E2579K|HUWE1_uc004dsq.1_Missense_Mutation_p.E86K	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3771					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GCATCAGCCTCAGCCTCCAGC	0.517													4	19					0	0	0	0	T	53570870	T	T	53570870	3	4	12	1	0	0	0	0	1	0	0	0	7500	835	29	2	1861	2	HUWE1	23	53570870	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	43369262	53570870	101699690	53	2918											
WNK3	65267	broad.mit.edu	37	chrX	54335724	54335724	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccttaagacctttggtttCatgactttaaatcgttttaa	10	18	5	8	1	1	2	1	1	0	1	3	2	2	2	2	1	0	2	2	1	4	7			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chrX:54335724C>T	uc004dtd.1	-	4	1174	c.735G>A	c.(733-735)ATG>ATA	p.M245I	WNK3_uc004dtc.1_Missense_Mutation_p.M245I	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	245	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						CCTTTGGTTTCATGACTTTAA	0.368													5	48					0	0	0	0	T	54335724	T	T	54335724	3	4	12	1	0	0	0	0	1	0	0	0	17447	826	29	2	4751	2	WNK3	23	54335724	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	764854	54335724	100934836	54	2919											
HEPH	9843	broad.mit.edu	37	chrX	65411985	65411985	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcagatggcatgcaggcActctacaaggtcaagtcttg	10	10	10	11	0	4	1	2	0	2	1	4	1	4	1	1	3	2	3	1	3	3	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chrX:65411985A>C	uc011moz.1	+	7	1146	c.1086A>C	c.(1084-1086)GCA>GCC	p.A362A	HEPH_uc004dwn.2_Silent_p.A362A|HEPH_uc004dwo.2_Silent_p.A92A|HEPH_uc010nkr.2_Silent_p.A362A|HEPH_uc011mpa.1_Silent_p.A362A	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	359	Extracellular (Potential).|Plastocyanin-like 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						GCATGCAGGCACTCTACAAGG	0.488													13	52					0	0	0	0	C	65411985	C	C	65411985	2	2	12	1	0	0	0	0	0	0	0	1	7093	146	6	5		5	HEPH	23	65411985	Silent	SNP	A	TCGA-BA-5557-01A-01D-1512-08	11076261	65411985	89858575	55	2920											
BHLHB9	80823	broad.mit.edu	37	chrX	102004645	102004645	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccaggcaccatctgaggCaagccctccttcatatattg	10	10	7	14	0	2	1	1	1	1	0	4	1	4	1	4	2	1	2	4	2	3	4			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chrX:102004645C>A	uc010nog.2	+	4	1293	c.722C>A	c.(721-723)GCA>GAA	p.A241E	BHLHB9_uc011mrq.1_Missense_Mutation_p.A241E|BHLHB9_uc011mrr.1_Missense_Mutation_p.A241E|BHLHB9_uc011mrs.1_Missense_Mutation_p.A241E|BHLHB9_uc011mrt.1_Missense_Mutation_p.A241E|BHLHB9_uc004ejo.2_Missense_Mutation_p.A241E|BHLHB9_uc011mru.1_Missense_Mutation_p.A241E|BHLHB9_uc011mrv.1_Missense_Mutation_p.A241E	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	241						cytoplasm|nucleus	binding			ovary(2)	2						CCATCTGAGGCAAGCCCTCCT	0.517													16	151					6.31663e-08	6.68819e-08	1	0	A	102004645	A	A	102004645	3	1	12	1	0	0	0	0	1	0	0	0	1423	710	25	4	724	4	BHLHB9	23	102004645	Missense_Mutation	SNP	C	TCGA-BA-5557-01A-01D-1512-08	36592660	102004645	53265915	56	2921											
SEPT6	23157	broad.mit.edu	37	chrX	118797579	118797579	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtgtgtgggtggctggctcCccttcgaatttggtgttgaa	4	15	15	7	1	0	1	0	1	0	0	2	2	1	1	2	4	0	3	2	4	2	3			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chrX:118797579C>T	uc004erv.2	-	3	472	c.207G>A	c.(205-207)GGG>GGA	p.G69G	SEPT6_uc010nqk.2_RNA|SEPT6_uc004ers.2_Silent_p.G69G|SEPT6_uc004ert.2_Silent_p.G69G|SEPT6_uc004eru.2_Silent_p.G69G|SEPT6_uc004erw.2_Silent_p.G11G|SEPT6_uc011mtv.1_Silent_p.G11G|SEPT6_uc011mtw.1_Silent_p.G99G	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	69					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4						TGGCTGGCTCCCCTTCGAATT	0.473													73	289					0	0	0	0	T	118797579	T	T	118797579	2	4	12	1	0	0	0	0	0	0	0	1	14133	610	22	4		4	SEPT6	23	118797579	Silent	SNP	C	TCGA-BA-5557-01A-01D-1512-08	16792934	118797579	36472981	57	2922											
SPANXN4	441525	broad.mit.edu	37	chrX	142121809	142121811	+	Splice_Site	DEL	AGA	-	-																															cctctccctgtttttttaccAgaagaagaagaatctgcaca																										TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chrX:142121809_142121811delAGA	uc004fbv.3	+	2	176	c.79_splice	c.e2-1	p.K27_splice		NM_001009613	NP_001009613	Q5MJ08	SPXN4_HUMAN	SPANX family, member N4											ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TTTTTTTACCAGAAGAAGAAGAA	0.414													---	---	---								-	142121811	-	-	142121809	8	5	12	1	0	1	0	1	0	0	1	0	15059	202	7	0	83	0	SPANXN4	23	142121809	Splice_Site	DEL	AGA	TCGA-BA-5557-01A-01D-1512-08	23324230	142121809	13148751	58	2923											
VBP1	7411	broad.mit.edu	37	chrX	154467052	154467052	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctttgacaattcttgcaGatatggccagggtttataat	10	17	8	6	0	2	2	0	1	2	1	2	2	2	2	1	2	1	2	1	2	4	8			TCGA-BA-5557-01A-01D-1512-08	TCGA-BA-5557-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7caa2a2f-3b77-46f0-9886-37f6e4278d83	47dd8b1c-117a-4793-8956-859d61284da8	g.chrX:154467052G>C	uc004fnc.2	+	6	583	c.524_splice	c.e6-1	p.N175_splice	VBP1_uc004fnd.2_Splice_Site_p.N138_splice	NM_003372	NP_003363	P61758	PFD3_HUMAN	von Hippel-Lindau binding protein 1						'de novo' posttranslational protein folding	nucleus|prefoldin complex	unfolded protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AATTCTTGCAGATATGGCCAG	0.338													10	191					0	0	0	0	C	154467052	C	C	154467052	5	2	12	1	0	0	0	0	0	0	1	0	17204	956	33	2	545	2	VBP1	23	154467052	Splice_Site	SNP	G	TCGA-BA-5557-01A-01D-1512-08	12345243	154467052	803508	59	2924											
PRDM16	63976	broad.mit.edu	37	chr1	3342265	3342265	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccgctgcttcgggcagcaGaccaacctggaccggcacct	9	5	11	16	3	0	1	0	0	0	1	1	2	0	2	5	3	4	5	5	3	2	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:3342265G>A	uc001akf.2	+	13	3140	c.3060G>A	c.(3058-3060)CAG>CAA	p.Q1020Q	PRDM16_uc001akc.2_Silent_p.Q1019Q|PRDM16_uc001akd.2_Silent_p.Q1019Q|PRDM16_uc001ake.2_Silent_p.Q1020Q|PRDM16_uc009vlh.2_Silent_p.Q720Q	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	1020	Mediates interaction with SKI and regulation of TGF-beta signaling.|C2H2-type 10.|Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TCGGGCAGCAGACCAACCTGG	0.647			T	EVI1	MDS|AML								24	104					0	0	0	0	A	3342265	A	A	3342265	2	1	13	1	0	0	0	0	0	0	0	1	12519	933	33	2		2	PRDM16	1	3342265	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08		3342265	245908356	1	2925											
PRAMEF8	391002	broad.mit.edu	37	chr1	12979810	12979810	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgtcacgctgacccatttCagccctgagcccctcacagg	7	8	10	16	1	3	2	3	2	0	0	3	2	3	2	4	2	2	1	4	2	0	1	rs144939857		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:12979810C>T	uc001aup.2	+	4	1085	c.1002C>T	c.(1000-1002)TTC>TTT	p.F334F		NM_001012276	NP_001012276	Q5VWM4	PRAM8_HUMAN	PRAME family member 8	334	LRR 1.										0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGACCCATTTCAGCCCTGAGC	0.577													49	269					0	0	0	0	T	12979810	T	T	12979810	2	4	13	1	0	0	0	0	0	0	0	1	12502	825	29	2		2	PRAMEF8	1	12979810	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	9637545	12979810	236270811	2	2926											
PLEKHM2	23207	broad.mit.edu	37	chr1	16046258	16046258	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacctagacctggccccctaCatgcccgactactacaaacc	11	7	5	18	1	0	1	0	0	0	1	0	2	0	1	6	1	6	0	6	1	6	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:16046258C>T	uc010obo.1	+	6	722	c.495C>T	c.(493-495)TAC>TAT	p.Y165Y		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	165	Interaction with KIF5B.				Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TGGCCCCCTACATGCCCGACT	0.587													14	83					0	0	0	0	T	16046258	T	T	16046258	2	4	13	1	0	0	0	0	0	0	0	1	12136	489	17	4		4	PLEKHM2	1	16046258	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	3066448	16046258	233204363	3	2927											
UBR4	23352	broad.mit.edu	37	chr1	19487411	19487411	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcatcagtcagccccacCtggttctgtaattcctcccg	7	10	9	15	1	3	0	2	0	1	0	5	1	5	1	5	2	2	3	5	2	1	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:19487411C>T	uc001bbi.2	-	38	5410	c.5406G>A	c.(5404-5406)CAG>CAA	p.Q1802Q	UBR4_uc001bbm.1_Silent_p.Q1013Q	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1802					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCAGCCCCACCTGGTTCTGTA	0.512													12	36					0	0	0	0	T	19487411	T	T	19487411	2	4	13	1	0	0	0	0	0	0	0	1	16972	695	24	4		4	UBR4	1	19487411	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	3441153	19487411	229763210	4	2928											
ALPL	249	broad.mit.edu	37	chr1	21903944	21903944	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccacggcggggaggacgtgGccgtcttctccaagggcccc	5	5	15	16	4	2	0	0	0	2	0	3	2	2	2	5	6	0	0	5	6	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:21903944G>T	uc001bet.2	+	12	1635	c.1378G>T	c.(1378-1380)GCC>TCC	p.A460S	ALPL_uc010odn.1_Missense_Mutation_p.A408S|ALPL_uc010odo.1_Missense_Mutation_p.A405S|ALPL_uc010odp.1_Missense_Mutation_p.A383S|ALPL_uc001beu.3_Missense_Mutation_p.A460S	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	460					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	GGAGGACGTGGCCGTCTTCTC	0.667													7	66					2.7689e-08	2.94836e-08	1	0	T	21903944	T	T	21903944	3	4	13	1	0	0	0	0	1	0	0	0	547	1203	42	4	1420	4	ALPL	1	21903944	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	2416533	21903944	227346677	5	2929											
NRD1	4898	broad.mit.edu	37	chr1	52280475	52280475	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttccaccaaacagtgcaaGagcccagcatctacaggtgg	13	7	9	12	0	1	1	0	0	1	1	2	1	2	1	3	2	5	2	3	2	3	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:52280475G>C	uc001ctc.3	-	14	1976	c.1654C>G	c.(1654-1656)CTT>GTT	p.L552V	NRD1_uc009vzb.2_Missense_Mutation_p.L247V|NRD1_uc001ctd.3_Missense_Mutation_p.L484V|NRD1_uc001cte.2_Missense_Mutation_p.L420V|NRD1_uc001ctf.2_Missense_Mutation_p.L484V|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.L352V	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	483					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						AACAGTGCAAGAGCCCAGCAT	0.378													11	54					0	0	0	0	C	52280475	C	C	52280475	3	2	13	1	0	0	0	0	1	0	0	0	10699	942	33	2	2085	2	NRD1	1	52280475	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	30376531	52280475	196970146	6	2930											
C1orf168	199920	broad.mit.edu	37	chr1	57254662	57254662	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaccttccccctgagtcttGggaacagcagctggctgcct	6	11	10	14	0	1	1	0	1	1	0	2	2	2	2	4	2	5	3	4	2	2	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:57254662G>A	uc001cym.3	-	3	1309	c.903C>T	c.(901-903)CCC>CCT	p.P301P	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Silent_p.P301P	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	301										ovary(3)|skin(2)	5						CCTGAGTCTTGGGAACAGCAG	0.602													38	158					0	0	0	0	A	57254662	A	A	57254662	2	1	13	1	0	0	0	0	0	0	0	1	2021	1335	47	4		4	C1orf168	1	57254662	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	4974187	57254662	191995959	7	2931											
WLS	79971	broad.mit.edu	37	chr1	68659750	68659750	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgaacagaaaacacgatGtcattggcttcaatttccct	13	12	7	9	1	2	2	2	1	0	1	3	3	3	2	1	1	2	1	1	1	4	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:68659750G>A	uc001def.1	-	2	538	c.267C>T	c.(265-267)GAC>GAT	p.D89D	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Silent_p.D87D|WLS_uc001deg.1_Intron|WLS_uc001deh.1_Silent_p.D89D|WLS_uc009wbf.1_Silent_p.D44D	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	89	Lumenal (Potential).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						AAAACACGATGTCATTGGCTT	0.463													18	86					0	0	0	0	A	68659750	A	A	68659750	2	1	13	1	0	0	0	0	0	0	0	1	17444	1368	48	4		4	WLS	1	68659750	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	11405088	68659750	180590871	8	2932											
ZNF326	284695	broad.mit.edu	37	chr1	90459559	90459559	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttggtcttctcttgtggatgCctggatcctactgctgccat	4	16	10	11	0	2	0	0	0	2	0	4	2	3	2	3	3	4	1	3	3	1	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:90459559C>T	uc001dnq.2	+						GEMIN8P4_uc001dno.2_RNA|ZNF326_uc001dnp.3_5'Flank|ZNF326_uc009wda.1_5'Flank|ZNF326_uc001dnr.2_5'Flank	NM_182976	NP_892021	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			ovary(1)	1		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		CTTGTGGATGCCTGGATCCTA	0.517													4	189					0	0	0	0	T	90459559	T	T	90459559	1	4	13	0	1	0	0	0	0	0	0	0	17913	754	26	4		4	ZNF326	1	90459559	5'Flank	SNP	C	TCGA-BA-5558-01A-01D-1512-08	21799809	90459559	158791062	9	2933											
MTMR11	10903	broad.mit.edu	37	chr1	149905309	149905309	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttattctcaccaggcaggcaGagggccctcagcctcaggtg	8	8	12	13	0	3	1	3	0	1	1	4	1	3	1	3	4	1	2	3	4	1	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:149905309G>A	uc001etl.3	-	10	1226	c.975C>T	c.(973-975)CTC>CTT	p.L325L	MTMR11_uc001etm.1_Silent_p.L253L|MTMR11_uc010pbm.1_Silent_p.L297L|MTMR11_uc010pbn.1_Silent_p.L167L	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	325	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CAGGCAGGCAGAGGGCCCTCA	0.557													57	188					0	0	0	0	A	149905309	A	A	149905309	2	1	13	1	0	0	0	0	0	0	0	1	9993	929	33	2		2	MTMR11	1	149905309	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	59445750	149905309	99345312	10	2934											
ARNT	405	broad.mit.edu	37	chr1	150808789	150808789	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgaagtggaaagctgctCacgaagtttatccacatcat	12	12	8	9	1	3	1	2	1	1	0	4	3	4	2	1	1	2	3	1	1	4	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:150808789C>T	uc001evr.1	-	7	810	c.667G>A	c.(667-669)GAG>AAG	p.E223K	ARNT_uc001evs.1_Missense_Mutation_p.E208K|ARNT_uc009wmb.1_Missense_Mutation_p.E214K|ARNT_uc009wmc.1_Missense_Mutation_p.E223K|ARNT_uc009wmd.1_Missense_Mutation_p.E208K|ARNT_uc009wme.1_Missense_Mutation_p.E223K|ARNT_uc010pcl.1_Missense_Mutation_p.E207K	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	223	PAS 1.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAAAGCTGCTCACGAAGTTTA	0.448			T	ETV6	AML								28	84					0	0	0	0	T	150808789	T	T	150808789	3	4	13	1	0	0	0	0	1	0	0	0	967	835	29	2	1766	2	ARNT	1	150808789	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	903480	150808789	98441832	11	2935											
MRPL9	65005	broad.mit.edu	37	chr1	151732598	151732598	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtacttatatcttttggtCttgggcttctcaaagttcac	8	17	7	9	0	4	0	2	0	3	0	5	0	4	0	0	2	1	3	0	2	4	8			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:151732598C>A	uc001eyv.2	-	7	817	c.732G>T	c.(730-732)AAG>AAT	p.K244N	MRPL9_uc009wmz.2_RNA	NM_031420	NP_113608	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9 precursor	244					translation	mitochondrial ribosome	structural constituent of ribosome			ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ATCTTTTGGTCTTGGGCTTCT	0.493													25	70					1.64293e-13	1.81671e-13	1	0	A	151732598	A	A	151732598	3	1	13	1	0	0	0	0	1	0	0	0	9873	912	32	2	75	2	MRPL9	1	151732598	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	923809	151732598	97518023	12	2936											
ATP8B2	57198	broad.mit.edu	37	chr1	154309988	154309988	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcctacatcatcatcctCaacaccgttgtgcccatttc	8	13	5	15	1	3	0	3	0	0	0	6	0	5	0	4	1	3	1	4	1	2	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:154309988C>A	uc001fey.1	+	11	1248	c.1059C>A	c.(1057-1059)CTC>CTA	p.L353L	ATP8B2_uc001few.2_Silent_p.L334L|ATP8B2_uc001fex.2_Silent_p.L367L	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	353	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCATCATCCTCAACACCGTTG	0.532													117	403					1.39264e-60	1.56247e-60	1	0	A	154309988	A	A	154309988	2	1	13	1	0	0	0	0	0	0	0	1	1197	813	29	2		2	ATP8B2	1	154309988	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	2577390	154309988	94940633	13	2937											
PBXIP1	57326	broad.mit.edu	37	chr1	154926182	154926182	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacccagctattatcagagtCtgggcaggaggccatagttg	10	9	12	10	0	2	1	1	0	1	1	2	2	2	2	2	3	1	3	2	3	3	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:154926182C>T	uc001ffr.2	-	2	75	c.16G>A	c.(16-18)GAC>AAC	p.D6N	PBXIP1_uc001ffs.2_Intron|PBXIP1_uc010pep.1_Intron|PBXIP1_uc009woy.1_RNA	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	6					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTATCAGAGTCTGGGCAGGAG	0.607													10	24					0	0	0	0	T	154926182	T	T	154926182	3	4	13	1	0	0	0	0	1	0	0	0	11550	913	32	2	2219	2	PBXIP1	1	154926182	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	616194	154926182	94324439	14	2938											
USH2A	7399	broad.mit.edu	37	chr1	215848871	215848872	+	Frame_Shift_Del	DEL	AG	-	-																															ggcctccagggtcagtgtgtAgagagtgaaaggatccaggc																										TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:215848871_215848872delAG	uc001hku.1	-	63	12768_12769	c.12381_12382delCT	c.(12379-12384)CTCTACfs	p.L4127fs		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4127_4128	Fibronectin type-III 26.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTCAGTGTGTAGAGAGTGAAAG	0.559										HNSCC(13;0.011)			---	---	---								-	215848872	-	-	215848871	7	5	13	1	0	1	0	1	0	0	0	0	17104	420	15	0	3266	0	USH2A	1	215848871	Frame_Shift_Del	DEL	AG	TCGA-BA-5558-01A-01D-1512-08	60922689	215848871	33401750	15	2939											
USH2A	7399	broad.mit.edu	37	chr1	216369938	216369938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgttgaggtgattgttcaGaaagcatattgatgtcatac	12	14	10	5	0	2	4	2	3	0	1	2	4	2	4	0	1	2	3	0	1	3	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:216369938G>A	uc001hku.1	-	19	4595	c.4208C>T	c.(4207-4209)TCT>TTT	p.S1403F	USH2A_uc001hkv.2_Missense_Mutation_p.S1403F	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1403	Extracellular (Potential).|Fibronectin type-III 4.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGATTGTTCAGAAAGCATATT	0.408										HNSCC(13;0.011)			39	129					0	0	0	0	A	216369938	A	A	216369938	3	1	13	1	0	0	0	0	1	0	0	0	17104	942	33	2	11630	2	USH2A	1	216369938	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	521067	216369938	32880683	16	2940											
CHML	1122	broad.mit.edu	37	chr1	241798757	241798757	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctccatatcctgactggcGtagcaaaaagcttctgtgtg	9	12	9	11	1	1	1	0	1	1	0	4	1	4	1	3	1	2	3	3	1	4	3	rs113330678		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:241798757G>A	uc001hzd.2	-	1	476	c.312C>T	c.(310-312)TAC>TAT	p.Y104Y	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	104					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CCTGACTGGCGTAGCAAAAAG	0.438													116	342					0	0	0	0	A	241798757	A	A	241798757	2	1	13	1	0	0	0	0	0	0	0	1	3366	1140	40	1		1	CHML	1	241798757	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	25428819	241798757	7451864	17	2941											
OR2W3	343171	broad.mit.edu	37	chr1	248059077	248059077	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acccccatgtacttcttcctCgcccacctttccttcctgga	5	13	4	19	1	1	0	0	0	1	0	5	1	4	1	7	1	1	1	7	1	1	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr1:248059077C>T	uc001idp.1	+	3	458	c.189C>T	c.(187-189)CTC>CTT	p.L63L	OR2W3_uc010pzb.1_Silent_p.L63L	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			ACTTCTTCCTCGCCCACCTTT	0.572													49	261					0	0	0	0	T	248059077	T	T	248059077	2	4	13	1	0	0	0	0	0	0	0	1	11087	871	31	1		1	OR2W3	1	248059077	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	6260320	248059077	1191544	18	2942											
NT5C1B	93034	broad.mit.edu	37	chr2	18745214	18745214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccagcaaggaaaagagcttCgtctatctctagaccccagc	12	8	8	13	1	2	2	0	0	2	2	5	3	3	3	3	1	3	2	3	1	5	3	rs140939592	byFrequency	TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:18745214C>T	uc002rcz.2	-	10	1785	c.1681G>A	c.(1681-1683)GAA>AAA	p.E561K	NT5C1B_uc002rcy.2_Missense_Mutation_p.E561K|NT5C1B_uc010exr.2_Intron|NT5C1B_uc010yju.1_Missense_Mutation_p.E501K|NT5C1B_uc002rda.2_Missense_Mutation_p.E501K|NT5C1B_uc010yjv.1_Missense_Mutation_p.E578K|NT5C1B_uc010yjw.1_Missense_Mutation_p.E544K|NT5C1B_uc010exs.2_Missense_Mutation_p.E563K	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	561					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AAAAGAGCTTCGTCTATCTCT	0.537													38	118					0	0	0	0	T	18745214	T	T	18745214	3	4	13	1	0	0	0	0	1	0	0	0	10740	893	31	1	155	1	NT5C1B	2	18745214	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08		18745214	224454159	19	2943											
XDH	7498	broad.mit.edu	37	chr2	31621533	31621533	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgccaggggtgcagaacccGcactgggagccgtggctttt	7	8	15	11	2	0	1	0	0	0	1	0	2	0	2	3	4	4	3	3	4	1	2	rs118042822	by1000genomes	TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:31621533G>A	uc002rnv.1	-	5	418	c.339C>T	c.(337-339)TGC>TGT	p.C113C		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	113		Iron-sulfur (2Fe-2S) 2.			purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGCAGAACCCGCACTGGGAGC	0.552													55	176					0	0	0	0	A	31621533	A	A	31621533	2	1	13	1	0	0	0	0	0	0	0	1	17494	1079	38	1		1	XDH	2	31621533	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	12876319	31621533	211577840	20	2944											
BIRC6	57448	broad.mit.edu	37	chr2	32641134	32641153	+	Frame_Shift_Del	DEL	AGTGGAGCCTCCCAAAAAGG	-	-																															aactttgaaattttggccaaAgtggagcctcccaaaaagga																										TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:32641134_32641153delAGTGGAGCCTCCCAAAAAGG	uc010ezu.2	+	10	2909_2928	c.2775_2794delAGTGGAGCCTCCCAAAAAGG	c.(2773-2796)AAAGTGGAGCCTCCCAAAAAGGAGfs	p.K925fs		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	925_932					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTTTGGCCAAAGTGGAGCCTCCCAAAAAGGAGGGCACTGA	0.414													---	---	---								-	32641153	-	-	32641134	7	5	13	1	0	1	0	1	0	0	0	0	1441	69	3	0	2813	0	BIRC6	2	32641134	Frame_Shift_Del	DEL	AGTGGAGCCTCCCAAAAAGG	TCGA-BA-5558-01A-01D-1512-08	1019601	32641134	210558239	21	2945											
FAM98A	25940	broad.mit.edu	37	chr2	33813507	33813507	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aactcttgaaagacctcactAccgcctccttcttgagcttt	9	13	5	14	1	3	3	1	2	2	1	4	3	4	3	4	0	3	1	4	0	3	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:33813507A>G	uc002rpa.1	-	4	491	c.417T>C	c.(415-417)GGT>GGC	p.G139G	FAM98A_uc010yne.1_Intron|FAM98A_uc010ynd.1_5'Flank|FAM98A_uc002roz.1_Silent_p.G16G	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	139										ovary(1)	1	all_hematologic(175;0.115)					AGACCTCACTACCGCCTCCTT	0.413													41	180					0	0	0	0	G	33813507	G	G	33813507	2	3	13	1	0	0	0	0	0	0	0	1	5688	378	14	5		5	FAM98A	2	33813507	Silent	SNP	A	TCGA-BA-5558-01A-01D-1512-08	1172373	33813507	209385866	22	2946											
USP34	9736	broad.mit.edu	37	chr2	61447483	61447483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aattgtgagccaaaagaaacCgctcgacccagttttccata	14	9	7	11	2	0	2	0	1	0	1	2	3	1	2	4	0	2	2	4	0	5	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:61447483C>T	uc002sbe.2	-	67	8031	c.8009G>A	c.(8008-8010)CGG>CAG	p.R2670Q		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	2670					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CAAAAGAAACCGCTCGACCCA	0.378													103	383					0	0	0	0	T	61447483	T	T	61447483	3	4	13	1	0	0	0	0	1	0	0	0	17133	652	23	1	2687	1	USP34	2	61447483	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	27633976	61447483	181751890	23	2947											
C2orf3	6936	broad.mit.edu	37	chr2	75921517	75921517	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtatttttcatactccctCaggtgtgagcggtgagtttc	7	15	10	9	2	2	2	2	2	0	0	4	2	3	2	1	2	2	2	1	2	2	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:75921517C>T	uc002sno.2	-	6	1000	c.870G>A	c.(868-870)CTG>CTA	p.L290L	C2orf3_uc010ffs.2_5'UTR|C2orf3_uc002snn.2_Silent_p.L121L|C2orf3_uc010fft.2_5'UTR	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	290	Potential.				negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						CATACTCCCTCAGGTGTGAGC	0.294													51	178					0	0	0	0	T	75921517	T	T	75921517	2	4	13	1	0	0	0	0	0	0	0	1	2172	813	29	2		2	C2orf3	2	75921517	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	14474034	75921517	167277856	24	2948											
RFTN2	130132	broad.mit.edu	37	chr2	198498526	198498526	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatgatgaagttcttcctCaattccgctttcagatgact	9	16	6	10	1	4	4	3	3	1	1	6	4	6	4	2	0	0	2	2	0	2	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:198498526C>G	uc002uuo.3	-	4	1036	c.634G>C	c.(634-636)GAG>CAG	p.E212Q		NM_144629	NP_653230	Q52LD8	RFTN2_HUMAN	raftlin family member 2	212						plasma membrane					0						AGTTCTTCCTCAATTCCGCTT	0.403													65	155					0	0	0	0	G	198498526	G	G	198498526	3	3	13	1	0	0	0	0	1	0	0	0	13324	835	29	2	895	2	RFTN2	2	198498526	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	122577009	198498526	44700847	25	2949											
STK36	27148	broad.mit.edu	37	chr2	219562684	219562684	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctccttataggtgtcttggCcgacctcagggactcagaag	8	10	11	12	1	3	1	2	0	1	1	4	3	4	2	4	3	0	0	4	3	3	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:219562684C>T	uc002viu.2	+	25	3283	c.3017C>T	c.(3016-3018)GCC>GTC	p.A1006V	STK36_uc002viv.2_Missense_Mutation_p.A985V|STK36_uc002viw.2_Missense_Mutation_p.A184V|STK36_uc002vix.2_Missense_Mutation_p.A51V	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	1006					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GGTGTCTTGGCCGACCTCAGG	0.547													4	172					0	0	0	0	T	219562684	T	T	219562684	3	4	13	1	0	0	0	0	1	0	0	0	15368	739	26	4	3111	4	STK36	2	219562684	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	21064158	219562684	23636689	26	2950											
FARP2	9855	broad.mit.edu	37	chr2	242312558	242312558	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaacatacagagtcctgcaGactgcagggatgcgcttggg	10	7	15	9	1	0	2	0	0	0	2	1	4	1	4	1	3	5	3	1	3	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr2:242312558G>A	uc002wbi.1	+	2	153	c.36G>A	c.(34-36)CAG>CAA	p.Q12Q	FARP2_uc010zoq.1_Silent_p.Q12Q|FARP2_uc010zor.1_Silent_p.Q12Q	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	12					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GAGTCCTGCAGACTGCAGGGA	0.488													36	79					0	0	0	0	A	242312558	A	A	242312558	2	1	13	1	0	0	0	0	0	0	0	1	5709	933	33	2		2	FARP2	2	242312558	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	22749874	242312558	886815	27	2951											
CHDH	55349	broad.mit.edu	37	chr3	53852082	53852082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcgctgtcggcttttgcccGcacaaaggcatctatctctt	6	12	10	13	3	2	0	0	0	2	0	4	0	2	0	1	3	1	4	1	3	2	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:53852082G>A	uc003dgz.2	-	9	1947	c.1507C>T	c.(1507-1509)CGG>TGG	p.R503W		NM_018397	NP_060867	Q8NE62	CHDH_HUMAN	choline dehydrogenase precursor	503					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			ovary(1)|central_nervous_system(1)	2		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	GCTTTTGCCCGCACAAAGGCA	0.582													4	141					0	0	0	0	A	53852082	A	A	53852082	3	1	13	1	0	0	0	0	1	0	0	0	3348	1086	38	1	281	1	CHDH	3	53852082	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08		53852082	144170348	28	2952											
TFG	10342	broad.mit.edu	37	chr3	100463729	100463729	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctatggtgcacagcagccGcaggctccacctcagcagcc	8	5	12	16	1	1	0	1	0	0	0	2	0	2	0	4	3	5	6	4	3	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:100463729G>A	uc003due.2	+	7	1223	c.774G>A	c.(772-774)CCG>CCA	p.P258P	TFG_uc003duf.2_Silent_p.P258P|TFG_uc003dug.2_Silent_p.P254P|TFG_uc003duh.2_Silent_p.P254P|TFG_uc003dui.2_Silent_p.P258P	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	258					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						CACAGCAGCCGCAGGCTCCAC	0.468			T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								19	103					0	0	0	0	A	100463729	A	A	100463729	2	1	13	1	0	0	0	0	0	0	0	1	15872	1074	38	1		1	TFG	3	100463729	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	46611647	100463729	97558701	29	2953											
C3orf1	51300	broad.mit.edu	37	chr3	119236073	119236073	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcctgtaggaggcctgctGatggcatttcagaagtactc	9	11	11	10	0	1	2	1	1	0	1	3	3	2	3	2	3	2	4	2	3	3	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:119236073G>A	uc003ecn.2	+	6	831	c.618G>A	c.(616-618)CTG>CTA	p.L206L	C3orf1_uc003eco.2_RNA|C3orf1_uc003ecp.2_RNA	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300	206	Helical; (Potential).					integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		GAGGCCTGCTGATGGCATTTC	0.453													29	144					0	0	0	0	A	119236073	A	A	119236073	2	1	13	1	0	0	0	0	0	0	0	1	2216	1277	45	2		2	C3orf1	3	119236073	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	18772344	119236073	78786357	30	2954											
CD80	941	broad.mit.edu	37	chr3	119248743	119248743	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tactgagattaaggtaatggCccaggatgggagcaggttat	12	10	14	5	0	0	1	0	1	0	1	0	4	0	3	1	5	2	3	1	5	4	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:119248743C>T	uc003ecq.2	-	5	1137	c.742G>A	c.(742-744)GCC>ACC	p.A248T	CD80_uc010hqt.1_Intron|CD80_uc010hqu.1_Intron	NM_005191	NP_005182	P33681	CD80_HUMAN	CD80 antigen precursor	248	Helical; (Potential).				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2					Abatacept(DB01281)	AAGGTAATGGCCCAGGATGGG	0.403													20	114					0	0	0	0	T	119248743	T	T	119248743	3	4	13	1	0	0	0	0	1	0	0	0	3053	739	26	4	132	4	CD80	3	119248743	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	12670	119248743	78773687	31	2955											
CCDC48	79825	broad.mit.edu	37	chr3	128755858	128755858	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggaagagaatgagcacctGaggctggagctgcagatggt	11	7	17	6	0	0	4	0	2	0	2	0	7	0	6	1	4	3	4	1	4	2	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:128755858G>A	uc011bkt.1	+	6	1488	c.1488G>A	c.(1486-1488)CTG>CTA	p.L496L		NM_024768	NP_079044	Q9HA90	CCD48_HUMAN	coiled-coil domain containing 48	496	Potential.										0						ATGAGCACCTGAGGCTGGAGC	0.627													20	65					0	0	0	0	A	128755858	A	A	128755858	2	1	13	1	0	0	0	0	0	0	0	1	2832	1277	45	2		2	CCDC48	3	128755858	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	9507115	128755858	69266572	32	2956											
AMOTL2	51421	broad.mit.edu	37	chr3	134086483	134086483	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaggtggctgaggaggcctgGgcactcactggcccctccac	6	6	15	14	0	1	1	1	1	0	0	2	3	2	2	4	6	0	2	4	6	0	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:134086483G>A	uc003eqf.2	-	3	1188	c.1071C>T	c.(1069-1071)GCC>GCT	p.A357A	AMOTL2_uc003eqg.1_Silent_p.A299A|AMOTL2_uc003eqh.1_Silent_p.A299A|AMOTL2_uc003eqe.1_5'Flank	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	299										large_intestine(1)	1						AGGAGGCCTGGGCACTCACTG	0.667													27	88					0	0	0	0	A	134086483	A	A	134086483	2	1	13	1	0	0	0	0	0	0	0	1	584	1219	43	4		4	AMOTL2	3	134086483	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	5330625	134086483	63935947	33	2957											
GRK7	131890	broad.mit.edu	37	chr3	141497261	141497261	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcccgggctgcagggctgCgcggagctccgccagaagct	5	5	16	15	4	0	1	0	0	0	1	1	2	1	2	3	3	5	5	3	3	1	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:141497261C>T	uc011bnd.1	+	1	219	c.135C>T	c.(133-135)TGC>TGT	p.C45C		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	45					visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						TGCAGGGCTGCGCGGAGCTCC	0.687													12	33					0	0	0	0	T	141497261	T	T	141497261	2	4	13	1	0	0	0	0	0	0	0	1	6833	776	27	1		1	GRK7	3	141497261	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	7410778	141497261	56525169	34	2958											
RAP2B	5912	broad.mit.edu	37	chr3	152880843	152880843	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgggcaacaaggtggacctgGagggtgagcgcgaggtctcg	8	6	19	8	3	1	1	0	1	1	0	2	4	1	3	1	6	2	1	1	6	2	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:152880843G>C	uc003ezr.2	+	1	815	c.361G>C	c.(361-363)GAG>CAG	p.E121Q		NM_002886	NP_002877	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family precursor	121					Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			lung(2)	2			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			GGTGGACCTGGAGGGTGAGCG	0.627													43	75					0	0	0	0	C	152880843	C	C	152880843	3	2	13	1	0	0	0	0	1	0	0	0	13106	1175	41	2	363	2	RAP2B	3	152880843	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	11383582	152880843	45141587	35	2959											
SLC7A14	57709	broad.mit.edu	37	chr3	170184960	170184960	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgccttcgcatctgacatCtgttggtaatagaagccttt	8	16	8	9	1	2	2	0	1	2	1	3	2	2	2	2	1	2	3	2	1	3	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:170184960C>G	uc003fgz.2	-	8	2515	c.2199G>C	c.(2197-2199)CAG>CAC	p.Q733H	CLDN11_uc011bpt.1_Intron|uc003fha.1_5'Flank	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	733						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CATCTGACATCTGTTGGTAAT	0.532													48	208					0	0	0	0	G	170184960	G	G	170184960	3	3	13	1	0	0	0	0	1	0	0	0	14760	912	32	2	120	2	SLC7A14	3	170184960	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	17304117	170184960	27837470	36	2960											
EIF4G1	1981	broad.mit.edu	37	chr3	184043113	184043113	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcattaaagaaaagaagacGtcatcccgcatccgctttat	15	10	6	10	3	2	3	2	0	0	3	4	3	4	3	2	0	0	2	2	0	6	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr3:184043113G>A	uc003fnp.2	+	19	3111	c.2913G>A	c.(2911-2913)ACG>ACA	p.T971T	EIF4G1_uc003fno.1_Silent_p.T912T|EIF4G1_uc010hxw.1_Silent_p.T807T|EIF4G1_uc003fnt.2_Silent_p.T682T|EIF4G1_uc003fnq.2_Silent_p.T884T|EIF4G1_uc003fnr.2_Silent_p.T807T|EIF4G1_uc010hxx.2_Silent_p.T978T|EIF4G1_uc003fns.2_Silent_p.T931T|EIF4G1_uc010hxy.2_Silent_p.T978T|EIF4G1_uc003fnv.3_Silent_p.T972T|EIF4G1_uc003fnu.3_Silent_p.T971T|EIF4G1_uc003fnw.2_Silent_p.T978T|EIF4G1_uc003fnx.2_Silent_p.T776T|EIF4G1_uc003fny.3_Silent_p.T775T|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	971	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AAAAGAAGACGTCATCCCGCA	0.522													32	162					0	0	0	0	A	184043113	A	A	184043113	2	1	13	1	0	0	0	0	0	0	0	1	5060	1132	40	1		1	EIF4G1	3	184043113	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	13858153	184043113	13979317	37	2961											
WHSC1	7468	broad.mit.edu	37	chr4	1976646	1976646	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcgatttatgaatcacagCtgccagcccaactgtgagac	11	10	8	12	1	2	2	1	2	1	1	3	4	2	2	2	0	4	1	2	0	3	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:1976646C>A	uc003gdz.3	+	19	3605	c.3429C>A	c.(3427-3429)AGC>AGA	p.S1143R	WHSC1_uc003geb.3_Missense_Mutation_p.S1143R|WHSC1_uc003gec.3_Missense_Mutation_p.S1143R|WHSC1_uc003ged.3_Missense_Mutation_p.S1143R|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.S362R|WHSC1_uc011bvh.1_Missense_Mutation_p.S204R|WHSC1_uc010icf.2_Missense_Mutation_p.S491R	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1143	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TGAATCACAGCTGCCAGCCCA	0.507			T	IGH@	MM								53	109					1.77205e-36	1.9785e-36	1	0	A	1976646	A	A	1976646	3	1	13	1	0	0	0	0	1	0	0	0	17430	796	28	4	3575	4	WHSC1	4	1976646	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08		1976646	189177630	38	2962											
HGFAC	3083	broad.mit.edu	37	chr4	3444828	3444828	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccccttccgctacgggggccGcatgctgcatgcctgcactt	4	9	11	17	3	0	0	0	0	0	0	1	0	1	0	5	2	5	5	5	2	1	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:3444828G>A	uc003ghc.2	+	3	353	c.350G>A	c.(349-351)CGC>CAC	p.R117H	HGFAC_uc010icw.2_Missense_Mutation_p.R117H	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	117	Fibronectin type-II.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TACGGGGGCCGCATGCTGCAT	0.721													3	16					0	0	0	0	A	3444828	A	A	3444828	3	1	13	1	0	0	0	0	1	0	0	0	7125	1087	38	1	360	1	HGFAC	4	3444828	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	1468182	3444828	187709448	39	2963											
TBC1D19	55296	broad.mit.edu	37	chr4	26719590	26719590	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccgggatacatctgtgttGagtcactttgcattcaacag	9	13	9	10	1	3	1	2	1	1	0	4	2	4	2	1	1	3	2	1	1	2	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:26719590G>A	uc003gsf.3	+	14	1260	c.990G>A	c.(988-990)TTG>TTA	p.L330L	TBC1D19_uc010iew.2_Silent_p.L330L|TBC1D19_uc011bxu.1_Silent_p.L265L	NM_018317	NP_060787	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	330	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)				CATCTGTGTTGAGTCACTTTG	0.303													34	105					0	0	0	0	A	26719590	A	A	26719590	2	1	13	1	0	0	0	0	0	0	0	1	15673	1281	45	2		2	TBC1D19	4	26719590	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	23274762	26719590	164434686	40	2964											
ANKRD17	26057	broad.mit.edu	37	chr4	73990774	73990774	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccaagatgagtggagtaaaAcctggagaaaaataatgatc	18	7	11	5	0	0	4	0	2	0	2	1	6	0	5	2	2	1	1	2	2	6	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:73990774A>G	uc003hgp.2	-	18	3465	c.3348T>C	c.(3346-3348)GGT>GGC	p.G1116G	ANKRD17_uc003hgo.2_Silent_p.G1003G|ANKRD17_uc003hgq.2_Silent_p.G865G|ANKRD17_uc003hgr.2_Silent_p.G1115G|ANKRD17_uc011cbd.1_Silent_p.G681G	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1116	ANK 17.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTGGAGTAAAACCTGGAGAAA	0.378													28	84					0	0	0	0	G	73990774	G	G	73990774	2	3	13	1	0	0	0	0	0	0	0	1	646	57	2	5		5	ANKRD17	4	73990774	Silent	SNP	A	TCGA-BA-5558-01A-01D-1512-08	47271184	73990774	117163502	41	2965											
MAPKSP1	8649	broad.mit.edu	37	chr4	100808471	100808471	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctttaataacaggtactcCatctctatctgacacaacaa	15	11	3	12	0	2	1	0	1	2	0	4	1	3	1	2	1	3	1	2	1	6	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:100808471C>T	uc003hvg.2	-	4	334	c.85G>A	c.(85-87)GGA>AGA	p.G29R	MAPKSP1_uc003hvi.2_RNA|MAPKSP1_uc003hvh.2_Missense_Mutation_p.G29R	NM_021970	NP_068805	Q9UHA4	LTOR3_HUMAN	MAPK scaffold protein 1	29					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	Ragulator complex	protein binding				0						ACAGGTACTCCATCTCTATCT	0.269													7	35					0	0	0	0	T	100808471	T	T	100808471	3	4	13	1	0	0	0	0	1	0	0	0	9346	603	21	4	305	4	MAPKSP1	4	100808471	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	26817697	100808471	90345805	42	2966											
PAPSS1	9061	broad.mit.edu	37	chr4	108552816	108552816	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatagtagtccatacgcttCtttttcttgttgtaagctgc	7	18	7	9	1	3	0	1	0	2	0	4	0	4	0	1	0	3	5	1	0	4	9			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:108552816C>G	uc003hyk.2	-	11	1791	c.1707G>C	c.(1705-1707)AAG>AAC	p.K569N		NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	569	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		CCATACGCTTCTTTTTCTTGT	0.423													45	174					0	0	0	0	G	108552816	G	G	108552816	3	3	13	1	0	0	0	0	1	0	0	0	11488	912	32	2	175	2	PAPSS1	4	108552816	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	7744345	108552816	82601460	43	2967											
CASP6	839	broad.mit.edu	37	chr4	110612108	110612108	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgtccaacttctctgtctGattatctactacatccaaag	10	14	6	11	0	3	1	0	1	3	0	6	1	5	1	2	1	3	0	2	1	5	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:110612108G>A	uc003hzn.1	-	6	619	c.541C>T	c.(541-543)CAG>TAG	p.Q181*	CASP6_uc003hzo.1_Nonsense_Mutation_p.Q92*	NM_001226	NP_001217	P55212	CASP6_HUMAN	caspase 6 isoform alpha preproprotein	181					cellular component disassembly involved in apoptosis|induction of apoptosis|proteolysis	cytosol|nucleoplasm	cysteine-type endopeptidase activity|protein binding			ovary(1)|breast(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000171)		TTCTCTGTCTGATTATCTACT	0.488													24	84					0	0	0	0	A	110612108	A	A	110612108	4	1	13	1	0	0	0	0	0	1	0	0	2687	1299	45	2	348	2	CASP6	4	110612108	Nonsense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	2059292	110612108	80542168	44	2968											
DCHS2	54798	broad.mit.edu	37	chr4	155256201	155256201	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtcttgagcagagaccatCaacgaaagtgtggtagattc	12	9	11	9	2	2	3	1	1	1	2	3	5	2	3	2	1	2	2	2	1	3	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:155256201C>T	uc003inw.2	-	8	1035	c.1035G>A	c.(1033-1035)TTG>TTA	p.L345L	DCHS2_uc003inx.2_Silent_p.L844L	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	345	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CAGAGACCATCAACGAAAGTG	0.408													25	90					0	0	0	0	T	155256201	T	T	155256201	2	4	13	1	0	0	0	0	0	0	0	1	4305	825	29	2		2	DCHS2	4	155256201	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	44644093	155256201	35898075	45	2969											
SNX25	83891	broad.mit.edu	37	chr4	186185722	186185722	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcaaaggatgtgcagtctCtcagcttacgtataatgctt	10	13	8	10	1	3	0	2	0	1	0	4	1	3	1	1	1	4	4	1	1	4	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr4:186185722C>T	uc003ixh.2	+	4	559	c.370C>T	c.(370-372)CTC>TTC	p.L124F		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	124	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		TGTGCAGTCTCTCAGCTTACG	0.403													43	93					0	0	0	0	T	186185722	T	T	186185722	3	4	13	1	0	0	0	0	1	0	0	0	14960	913	32	2	380	2	SNX25	4	186185722	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	30929521	186185722	4968554	46	2970											
PRDM9	56979	broad.mit.edu	37	chr5	23526395	23526395	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgtctggccttttcaagtCagaaatttctcagtcaacat	10	14	7	10	0	5	1	4	0	2	1	6	1	5	1	1	1	1	1	1	1	3	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:23526395C>G	uc003jgo.2	+	11	1380	c.1198C>G	c.(1198-1200)CAG>GAG	p.Q400E		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	400	C2H2-type 1.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CTTTTCAAGTCAGAAATTTCT	0.473										HNSCC(3;0.000094)			34	203					0	0	0	0	G	23526395	G	G	23526395	3	3	13	1	0	0	0	0	1	0	0	0	12525	827	29	2	1236	2	PRDM9	5	23526395	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08		23526395	157388865	47	2971											
ADAMTS12	81792	broad.mit.edu	37	chr5	33649669	33649669	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcacttactccaagaagcGggtgatgtactcctcgctgc	8	11	10	12	2	1	2	1	1	0	1	4	2	3	2	2	1	4	2	2	1	4	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:33649669G>A	uc003jia.1	-	8	1487	c.1324C>T	c.(1324-1326)CGC>TGC	p.R442C	ADAMTS12_uc010iuq.1_Missense_Mutation_p.R442C	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	442	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCCAAGAAGCGGGTGATGTAC	0.532										HNSCC(64;0.19)			9	132					0	0	0	0	A	33649669	A	A	33649669	3	1	13	1	0	0	0	0	1	0	0	0	257	1116	39	1	3528	1	ADAMTS12	5	33649669	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	10123274	33649669	147265591	48	2972											
NIPBL	25836	broad.mit.edu	37	chr5	36985741	36985741	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actaagacgtgaccatgataAtaaacaaaaatcagatgaca	21	7	6	7	1	1	5	1	3	0	2	1	5	1	5	1	0	1	0	1	0	6	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:36985741A>G	uc003jkl.3	+	10	2958	c.2459A>G	c.(2458-2460)AAT>AGT	p.N820S	NIPBL_uc003jkk.3_Missense_Mutation_p.N820S|NIPBL_uc003jkm.1_Missense_Mutation_p.N699S	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	820					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GACCATGATAATAAACAAAAA	0.438													6	129					0	0	0	0	G	36985741	G	G	36985741	3	3	13	1	0	0	0	0	1	0	0	0	10482	101	4	5	2493	5	NIPBL	5	36985741	Missense_Mutation	SNP	A	TCGA-BA-5558-01A-01D-1512-08	3336072	36985741	143929519	49	2973											
DAB2	1601	broad.mit.edu	37	chr5	39392478	39392478	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattcttaccccagttttctCatcaattatttttatcccag	10	18	2	11	0	3	0	2	0	2	0	5	0	4	0	3	0	1	1	3	0	5	8			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:39392478C>T	uc003jlx.2	-	4	850	c.319G>A	c.(319-321)GAG>AAG	p.E107K	DAB2_uc003jlw.2_Missense_Mutation_p.E107K	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	107	PID.				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CCAGTTTTCTCATCAATTATT	0.463													21	118					0	0	0	0	T	39392478	T	T	39392478	3	4	13	1	0	0	0	0	1	0	0	0	4235	835	29	2	2037	2	DAB2	5	39392478	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	2406737	39392478	141522782	50	2974											
PDE4D	5144	broad.mit.edu	37	chr5	58285677	58285677	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacatcagcatggtaatggtCttcgagagtcataagatatg	13	11	10	7	1	3	2	2	0	1	2	4	3	3	2	0	2	1	2	0	2	3	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:58285677C>T	uc003jsa.2	-	10	1529	c.1357G>A	c.(1357-1359)GAC>AAC	p.D453N	PDE4D_uc003jrx.2_Missense_Mutation_p.D317N|PDE4D_uc003jry.2_Missense_Mutation_p.D151N|PDE4D_uc003jrz.2_Missense_Mutation_p.D389N|PDE4D_uc003jsb.2_Missense_Mutation_p.D392N|PDE4D_uc003jrt.2_Missense_Mutation_p.D151N|PDE4D_uc003jru.2_Missense_Mutation_p.D229N|PDE4D_uc003jrv.2_Missense_Mutation_p.D323N|PDE4D_uc003jrw.2_Missense_Mutation_p.D331N|PDE4D_uc003jrs.2_Missense_Mutation_p.D162N	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	453					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	TGGTAATGGTCTTCGAGAGTC	0.343													17	72					0	0	0	0	T	58285677	T	T	58285677	3	4	13	1	0	0	0	0	1	0	0	0	11696	913	32	2	1096	2	PDE4D	5	58285677	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	18893199	58285677	122629583	51	2975											
MEF2C	4208	broad.mit.edu	37	chr5	88018491	88018491	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctttcgtccggcgaaggtCtggtgagtccaatgggggag	6	9	16	10	3	1	1	0	1	1	0	4	3	3	2	3	5	0	0	3	5	2	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:88018491C>T	uc003kjj.2	-	11	2025	c.1352G>A	c.(1351-1353)AGA>AAA	p.R451K	MEF2C_uc003kji.2_Missense_Mutation_p.R443K|MEF2C_uc003kjk.2_Missense_Mutation_p.R451K|MEF2C_uc003kjm.2_Missense_Mutation_p.R441K|MEF2C_uc003kjl.2_Missense_Mutation_p.R461K	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	451					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		CGGCGAAGGTCTGGTGAGTCC	0.498										HNSCC(66;0.2)			66	251					0	0	0	0	T	88018491	T	T	88018491	3	4	13	1	0	0	0	0	1	0	0	0	9510	913	32	2	73	2	MEF2C	5	88018491	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	29732814	88018491	92896769	52	2976											
SEMA6A	57556	broad.mit.edu	37	chr5	115783452	115783452	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggatgactgcaatggccaaGagggtgacgggaaccagctg	12	5	16	8	1	0	3	0	2	0	1	0	5	0	5	2	4	3	2	2	4	3	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:115783452G>A	uc010jck.2	-	19	2659	c.1950C>T	c.(1948-1950)CTC>CTT	p.L650L	SEMA6A_uc003krx.3_Silent_p.L667L|SEMA6A_uc011cwe.1_Silent_p.L29L|SEMA6A_uc003krv.3_Silent_p.L77L|SEMA6A_uc003krw.3_Silent_p.L127L|SEMA6A_uc010jcj.2_Silent_p.L194L	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	650	Helical; (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CAATGGCCAAGAGGGTGACGG	0.552													5	29					0	0	0	0	A	115783452	A	A	115783452	2	1	13	1	0	0	0	0	0	0	0	1	14104	929	33	2		2	SEMA6A	5	115783452	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	27764961	115783452	65131808	53	2977											
ADAMTS19	171019	broad.mit.edu	37	chr5	128862009	128862009	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaggtctagaaaaatagcaGaaagtggaagagggaaacga	19	5	13	4	1	1	3	0	0	1	3	1	6	1	5	0	3	2	1	0	3	8	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:128862009G>A	uc003kvb.1	+	4	928	c.928G>A	c.(928-930)GAA>AAA	p.E310K	ADAMTS19_uc003kvc.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	310					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AAAAATAGCAGAAAGTGGAAG	0.358													18	57					0	0	0	0	A	128862009	A	A	128862009	3	1	13	1	0	0	0	0	1	0	0	0	264	943	33	2	942	2	ADAMTS19	5	128862009	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	13078557	128862009	52053251	54	2978											
HSPA4	3308	broad.mit.edu	37	chr5	132400683	132400683	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcttctagggcttgcatttCttttggtcctaagaatcgtt	6	18	9	8	1	3	1	0	0	3	1	5	1	4	1	1	2	1	3	1	2	3	8			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:132400683C>G	uc003kyj.2	+	2	400	c.119C>G	c.(118-120)TCT>TGT	p.S40C		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	40					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCTTGCATTTCTTTTGGTCCT	0.323													33	161					0	0	0	0	G	132400683	G	G	132400683	3	3	13	1	0	0	0	0	1	0	0	0	7451	913	32	2	125	2	HSPA4	5	132400683	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	3538674	132400683	48514577	55	2979											
PCDHA1	56147	broad.mit.edu	37	chr5	140165886	140165886	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttttgcaatggtgttttCtaggagagggggcctgggag	6	13	16	6	0	1	1	0	0	1	1	2	3	2	2	2	5	1	2	2	5	2	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:140165886C>A	uc003lhb.2	+	1	11	c.11C>A	c.(10-12)TCT>TAT	p.S4Y	PCDHA1_uc003lha.2_Missense_Mutation_p.S4Y|PCDHA1_uc003lgz.2_Missense_Mutation_p.S4Y	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	4					homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGGTGTTTTCTAGGAGAGGG	0.502													47	225					2.76378e-25	3.07087e-25	1	0	A	140165886	A	A	140165886	3	1	13	1	0	0	0	0	1	0	0	0	11573	913	32	2	13	2	PCDHA1	5	140165886	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	7765203	140165886	40749374	56	2980											
PCDH12	51294	broad.mit.edu	37	chr5	141336011	141336011	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtaagttgttttcccgcGtggagacttcatacctgctt	7	14	11	9	2	1	1	1	0	0	1	2	2	2	1	2	2	2	4	2	2	2	7			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:141336011G>A	uc003llx.2	-	1	2617	c.1406C>T	c.(1405-1407)ACG>ATG	p.T469M		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	469	Extracellular (Potential).|Cadherin 5.				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTTCCCGCGTGGAGACTTC	0.478													35	143					0	0	0	0	A	141336011	A	A	141336011	3	1	13	1	0	0	0	0	1	0	0	0	11564	1145	40	1	2164	1	PCDH12	5	141336011	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	1170125	141336011	39579249	57	2981											
SH3RF2	153769	broad.mit.edu	37	chr5	145379752	145379752	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggggaaatcaatggcatCagcgggaacttcccagccag	12	5	13	11	1	2	0	2	0	0	0	3	2	3	2	2	4	3	1	2	4	3	1	rs137960488		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:145379752C>T	uc003lnt.2	+	3	748	c.510C>T	c.(508-510)ATC>ATT	p.I170I	SH3RF2_uc011dbl.1_Silent_p.I170I	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	170	SH3 1.						ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAATGGCATCAGCGGGAACT	0.567													19	81					0	0	0	0	T	145379752	T	T	145379752	2	4	13	1	0	0	0	0	0	0	0	1	14324	816	29	2		2	SH3RF2	5	145379752	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	4043741	145379752	35535508	58	2982											
GABRG2	2566	broad.mit.edu	37	chr5	161524718	161524718	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttaacagcaccattaaagtCctccgattgaacagcaacat	15	10	5	11	1	0	1	0	1	0	0	2	2	2	1	3	0	5	2	3	0	5	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr5:161524718C>T	uc003lyz.3	+	4	760	c.402C>T	c.(400-402)GTC>GTT	p.V134V	GABRG2_uc010jjc.2_Silent_p.V134V|GABRG2_uc003lyy.3_Silent_p.V134V|GABRG2_uc011dej.1_Silent_p.V39V	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	134	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CCATTAAAGTCCTCCGATTGA	0.378													30	128					0	0	0	0	T	161524718	T	T	161524718	2	4	13	1	0	0	0	0	0	0	0	1	6206	842	30	2		2	GABRG2	5	161524718	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	16144966	161524718	19390542	59	2983											
SERPINB6	5269	broad.mit.edu	37	chr6	2948610	2948610	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagaaaaggaaggggtggtcGgcgcagaagcgggggacgaa	14	2	20	5	4	0	2	0	0	0	2	1	5	0	4	0	7	1	1	0	7	6	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:2948610G>A	uc003muk.2	-	6	3048	c.1053C>T	c.(1051-1053)GCC>GCT	p.A351A	SERPINB6_uc003mui.2_Silent_p.A234A|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Silent_p.A351A|SERPINB6_uc003mum.2_Silent_p.A351A|SERPINB6_uc003mun.2_Silent_p.A351A|SERPINB6_uc003muo.2_Silent_p.A351A	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	351					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	AGGGGTGGTCGGCGCAGAAGC	0.587													13	58					0	0	0	0	A	2948610	A	A	2948610	2	1	13	1	0	0	0	0	0	0	0	1	14170	1103	39	1		1	SERPINB6	6	2948610	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08		2948610	168166457	60	2984											
HIST1H2BK	85236	broad.mit.edu	37	chr6	27114238	27114238	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgacggccttggtgccctCggacacggcgtgcttggcca	4	8	16	13	4	0	1	0	1	0	0	1	2	0	2	3	6	2	1	3	6	0	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:27114238C>T	uc003nix.1	-	1	382	c.340G>A	c.(340-342)GAG>AAG	p.E114K	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	114					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						TTGGTGCCCTCGGACACGGCG	0.582													28	125					0	0	0	0	T	27114238	T	T	27114238	3	4	13	1	0	0	0	0	1	0	0	0	7189	893	31	1	44	1	HIST1H2BK	6	27114238	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	24165628	27114238	144000829	61	2985											
GABBR1	2550	broad.mit.edu	37	chr6	29591083	29591083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgcccaacccctcctcaccGaagtgaagacctcagtggtc	9	8	8	16	1	2	2	2	1	0	1	4	3	3	2	6	1	2	0	6	1	3	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:29591083G>A	uc003nmt.3	-	8	1298	c.962C>T	c.(961-963)TCG>TTG	p.S321L	GABBR1_uc003nmp.3_Missense_Mutation_p.S204L|GABBR1_uc003nms.3_Missense_Mutation_p.S204L|GABBR1_uc003nmu.3_Missense_Mutation_p.S259L|GABBR1_uc011dlr.1_Missense_Mutation_p.S144L|GABBR1_uc011dls.1_Missense_Mutation_p.S321L	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	321	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	CCTCCTCACCGAAGTGAAGAC	0.517													13	50					0	0	0	0	A	29591083	A	A	29591083	3	1	13	1	0	0	0	0	1	0	0	0	6189	1072	37	1	1987	1	GABBR1	6	29591083	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	2476845	29591083	141523984	62	2986											
MDFI	4188	broad.mit.edu	37	chr6	41621181	41621181	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcgtgcctctgctgctgctgCtgtggctctggcgagtgtgc	1	13	15	12	2	2	0	0	0	2	0	3	1	2	0	1	2	6	5	1	2	0	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:41621181C>T	uc003oqp.3	+	6	938	c.609C>T	c.(607-609)TGC>TGT	p.C203C	MDFI_uc003oqq.3_Silent_p.C203C|MDFI_uc010jxn.2_Silent_p.C203C	NM_005586	NP_005577	Q99750	MDFI_HUMAN	MyoD family inhibitor	203	Cys-rich.				cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus					0	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			GCTGCTGCTGCTGTGGCTCTG	0.657													3	105					0	0	0	0	T	41621181	T	T	41621181	2	4	13	1	0	0	0	0	0	0	0	1	9457	805	28	4		4	MDFI	6	41621181	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	12030098	41621181	129493886	63	2987											
FRS3	10817	broad.mit.edu	37	chr6	41738550	41738550	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttctggggccccttagggCggtctccaccccagcccttt	3	10	12	16	1	2	0	0	0	2	0	3	0	2	0	6	5	1	1	6	5	1	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:41738550C>T	uc003orc.1	-	7	1530	c.1286G>A	c.(1285-1287)CGC>CAC	p.R429H		NM_006653	NP_006644	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	429					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			ovary(2)	2	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCCCTTAGGGCGGTCTCCACC	0.637													6	74					0	0	0	0	T	41738550	T	T	41738550	3	4	13	1	0	0	0	0	1	0	0	0	6096	768	27	1	196	1	FRS3	6	41738550	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	117369	41738550	129376517	64	2988											
GPR111	222611	broad.mit.edu	37	chr6	47649665	47649665	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatgtaggcctgggcatttCtatttgcagcctgatccttt	7	16	9	9	0	1	1	0	1	1	0	2	1	2	1	3	2	2	3	3	2	3	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:47649665C>G	uc010jzj.1	+	6	1371	c.1370C>G	c.(1369-1371)TCT>TGT	p.S457C	GPR111_uc010jzk.1_Missense_Mutation_p.S389C|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	457	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CTGGGCATTTCTATTTGCAGC	0.428													60	187					0	0	0	0	G	47649665	G	G	47649665	3	3	13	1	0	0	0	0	1	0	0	0	6666	913	32	2	1184	2	GPR111	6	47649665	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	5911115	47649665	123465402	65	2989											
TBX18	9096	broad.mit.edu	37	chr6	85469990	85469990	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgtatcttttgttgtcCactggtacaatatccatggc	8	16	7	10	0	1	0	0	0	1	0	3	0	3	0	3	2	2	3	3	2	5	7			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:85469990C>G	uc003pkl.1	-	3	582	c.582G>C	c.(580-582)GTG>GTC	p.V194V	TBX18_uc010kbq.1_Silent_p.V36V	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	194	T-box.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		TTTTGTTGTCCACTGGTACAA	0.388													11	69					0	0	0	0	G	85469990	G	G	85469990	2	3	13	1	0	0	0	0	0	0	0	1	15719	581	21	4		4	TBX18	6	85469990	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	37820325	85469990	85645077	66	2990											
MCM9	254394	broad.mit.edu	37	chr6	119245170	119245170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttgttacacatgtaatcccGctcaaactccagaaccttca	12	12	4	13	1	2	1	2	0	0	1	4	1	4	1	3	0	3	3	3	0	4	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:119245170G>A	uc003pyh.2	-	3	690	c.427C>T	c.(427-429)CGG>TGG	p.R143W		NM_153255	NP_694987	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	143					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			ovary(1)	1		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		ATGTAATCCCGCTCAAACTCC	0.468													5	350					0	0	0	0	A	119245170	A	A	119245170	3	1	13	1	0	0	0	0	1	0	0	0	9447	1086	38	1	768	1	MCM9	6	119245170	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	33775180	119245170	51869897	67	2991											
KIAA1244	57221	broad.mit.edu	37	chr6	138576900	138576900	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggaagccatcaaaataatGaaagaggtgaggaggcactg	16	6	14	5	0	1	3	1	2	0	1	1	5	1	5	1	4	1	1	1	4	5	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:138576900G>A	uc003qhu.2	+	10	1098	c.1098G>A	c.(1096-1098)ATG>ATA	p.M366I		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	366					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TCAAAATAATGAAAGAGGTGA	0.572													5	8					0	0	0	0	A	138576900	A	A	138576900	3	1	13	1	0	0	0	0	1	0	0	0	8256	1290	45	2	1136	2	KIAA1244	6	138576900	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	19331730	138576900	32538167	68	2992											
TTLL2	83887	broad.mit.edu	37	chr6	167754382	167754382	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagatttttttcctaccttCgtagctgggatgtggacgat	7	15	11	8	2	0	1	0	0	0	1	2	4	1	3	2	2	2	3	2	2	2	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr6:167754382C>T	uc003qvs.1	+	3	1082	c.994C>T	c.(994-996)CGT>TGT	p.R332C	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	332	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TTCCTACCTTCGTAGCTGGGA	0.463													81	256					0	0	0	0	T	167754382	T	T	167754382	3	4	13	1	0	0	0	0	1	0	0	0	16795	884	31	1	1004	1	TTLL2	6	167754382	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	29177482	167754382	3360685	69	2993											
SDK1	221935	broad.mit.edu	37	chr7	4169596	4169596	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggagccacatcgtgcgaggGaaccacacgcagtcggccct	10	4	13	14	4	0	0	0	0	0	0	2	3	0	2	3	3	3	1	3	3	1	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:4169596G>A	uc003smx.2	+	27	4135	c.3996G>A	c.(3994-3996)GGG>GGA	p.G1332G	SDK1_uc010kso.2_Silent_p.G608G|SDK1_uc003smy.2_5'UTR	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1332	Fibronectin type-III 7.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TCGTGCGAGGGAACCACACGC	0.652													25	72					0	0	0	0	A	4169596	A	A	4169596	2	1	13	1	0	0	0	0	0	0	0	1	14033	1161	41	2		2	SDK1	7	4169596	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08		4169596	154969067	70	2994											
MPP6	51678	broad.mit.edu	37	chr7	24727123	24727123	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcatacaaccactattttGatttgatcatcataaatgat	15	14	5	7	0	2	3	2	3	0	0	2	4	2	3	1	0	3	1	1	0	5	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:24727123G>A	uc003swx.2	+	13	1812	c.1513G>A	c.(1513-1515)GAT>AAT	p.D505N	MPP6_uc003swy.2_Missense_Mutation_p.D505N|MPP6_uc010kur.2_Missense_Mutation_p.D173N	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	505	Guanylate kinase-like.				protein complex assembly		protein binding				0						CCACTATTTTGATTTGATCAT	0.378													46	186					0	0	0	0	A	24727123	A	A	24727123	3	1	13	1	0	0	0	0	1	0	0	0	9791	1290	45	2	1555	2	MPP6	7	24727123	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	20557527	24727123	134411540	71	2995											
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26232925	26232925	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accaaagtttccactcttcaTtggaccgtagttagaaggtt	11	13	8	9	1	2	1	1	0	1	1	3	2	3	2	3	2	0	4	3	2	4	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:26232925T>C	uc003sxr.3	-	10	1162	c.946A>G	c.(946-948)ATG>GTG	p.M316V	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.M304V	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	316	Gly-rich.|Nuclear targeting sequence (By similarity).				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCACTCTTCATTGGACCGTAG	0.343			T	ETV1	prostate								4	176					0	0	0	0	C	26232925	C	C	26232925	3	2	13	1	0	0	0	0	1	0	0	0	7298	1493	52	5	123	5	HNRNPA2B1	7	26232925	Missense_Mutation	SNP	T	TCGA-BA-5558-01A-01D-1512-08	1505802	26232925	132905738	72	2996											
CBX3	11335	broad.mit.edu	37	chr7	26251377	26251377	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgatgtttctcatgaaatgGtgagtatgcagagattgtta	11	16	11	3	0	1	4	1	3	1	1	2	5	1	4	0	1	1	4	0	1	3	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:26251377G>C	uc003sxt.2	+	5	536	c.425_splice	c.e5+1	p.W142_splice	CBX3_uc003sxu.2_Splice_Site_p.W142_splice|CBX3_uc003sxv.2_Splice_Site	NM_007276	NP_009207	Q13185	CBX3_HUMAN	chromobox homolog 3						chromatin remodeling|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome, centromeric region|nuclear centromeric heterochromatin|nuclear euchromatin|nuclear inner membrane|spindle	enzyme binding|protein domain specific binding			ovary(1)	1						TCATGAAATGGTGAGTATGCA	0.368													21	62					0	0	0	0	C	26251377	C	C	26251377	5	2	13	1	0	0	0	0	0	0	1	0	2731	1275	44	4	440	4	CBX3	7	26251377	Splice_Site	SNP	G	TCGA-BA-5558-01A-01D-1512-08	18452	26251377	132887286	73	2997											
HOXA11	3207	broad.mit.edu	37	chr7	27224977	27224978	+	5'Flank	INS	-	T	T																															ccttttccccccccctttccINSttttttttttttcctcctct																										TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:27224977_27224978insT	uc003syx.2	-						HOXA11_uc003syy.2_5'Flank|HOXA11AS_uc003syz.1_5'Flank	NM_005523	NP_005514	P31270	HXA11_HUMAN	homeobox A11						branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)	2						CCCCCCTTTCCTTTTTTTTTTT	0.53			T	NUP98	CML						OREG0003746|OREG0003747	type=REGULATORY REGION|Gene=BC025338|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|Gene=HOXA11|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---								T	27224978	T	T	27224977	6	5	13	0	1	1	1	0	0	0	0	0	7329	696	24	0		0	HOXA11	7	27224977	5'Flank	INS	-	TCGA-BA-5558-01A-01D-1512-08	973600	27224977	131913686	74	2998											
SFRP4	6424	broad.mit.edu	37	chr7	37955829	37955829	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggctcgcagtcgtcgcgcGcgcgttggcacaccgacttg	4	7	16	14	8	0	0	0	0	0	0	3	1	0	0	1	3	0	4	1	3	0	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:37955829G>T	uc003tfo.3	-	1	697	c.311C>A	c.(310-312)GCG>GAG	p.A104E		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	104	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						GTCGTCGCGCGCGCGTTGGCA	0.627													17	46					6.94344e-10	7.49761e-10	1	0	T	37955829	T	T	37955829	3	4	13	1	0	0	0	0	1	0	0	0	14228	1087	38	3	753	3	SFRP4	7	37955829	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	10730852	37955829	121182834	75	2999											
ADCY1	107	broad.mit.edu	37	chr7	45753466	45753466	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcggaaaatgtgtccatttGggagagctggccttcagggc	9	10	14	8	1	1	1	1	0	0	1	3	3	2	2	2	4	1	1	2	4	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:45753466G>T	uc003tne.3	+	20	3250	c.3232G>T	c.(3232-3234)GGG>TGG	p.G1078W		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	1078	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GTGTCCATTTGGGAGAGCTGG	0.602													30	111					1.74807e-11	1.89649e-11	1	0	T	45753466	T	T	45753466	3	4	13	1	0	0	0	0	1	0	0	0	292	1348	47	4	3310	4	ADCY1	7	45753466	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	7797637	45753466	113385197	76	3000											
NAA38	51691	broad.mit.edu	37	chr7	117828389	117828389	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttggatgaaagccatgaaCgagtattcagctcttcacag	12	12	9	8	1	3	2	2	2	1	0	3	4	3	3	1	1	3	2	1	1	3	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:117828389C>T	uc003vjg.2	+	3	322	c.130C>T	c.(130-132)CGA>TGA	p.R44*		NM_016200	NP_057284	O95777	NAA38_HUMAN	U6 snRNA-associated Sm-like protein LSm8	44					nuclear mRNA splicing, via spliceosome	nucleus|ribonucleoprotein complex	protein binding|U6 snRNA binding				0						AAGCCATGAACGAGTATTCAG	0.338													41	138					0	0	0	0	T	117828389	T	T	117828389	4	4	13	1	0	0	0	0	0	1	0	0	10177	528	19	1	140	1	NAA38	7	117828389	Nonsense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	72074923	117828389	41310274	77	3001											
AKR1B10	57016	broad.mit.edu	37	chr7	134216705	134216705	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccttgtgaggaaagcctttGagaagaccctcaaggacctg	11	8	11	11	0	1	3	1	2	0	2	1	6	1	5	4	2	1	0	4	2	3	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:134216705G>C	uc003vrr.2	+	3	600	c.280G>C	c.(280-282)GAG>CAG	p.E94Q		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	94					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						GAAAGCCTTTGAGAAGACCCT	0.468													40	150					0	0	0	0	C	134216705	C	C	134216705	3	2	13	1	0	0	0	0	1	0	0	0	467	1291	45	2	290	2	AKR1B10	7	134216705	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	16388316	134216705	24921958	78	3002											
MGAM	8972	broad.mit.edu	37	chr7	141765212	141765212	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctcttctggccgctgggcagGacattggctgggagacaaca	8	8	14	11	1	2	1	0	0	2	1	2	3	2	2	1	5	1	3	1	5	1	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:141765212G>C	uc003vwy.2	+	38	4616	c.4562G>C	c.(4561-4563)GGA>GCA	p.G1521A		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1521	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CGCTGGGCAGGACATTGGCTG	0.622													4	11					0	0	0	0	C	141765212	C	C	141765212	3	2	13	1	0	0	0	0	1	0	0	0	9594	1174	41	2	4708	2	MGAM	7	141765212	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	7548507	141765212	17373451	79	3003											
C7orf29	113763	broad.mit.edu	37	chr7	150028028	150028028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatggggctgctggcctctGagagaagcgggggctcgctg	5	7	19	10	2	1	2	0	1	1	1	2	3	1	2	1	5	2	5	1	5	1	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:150028028G>A	uc003wgy.2	+	1	1091	c.535G>A	c.(535-537)GAG>AAG	p.E179K	LRRC61_uc003wgv.2_Intron|LRRC61_uc003wgx.2_Intron|LRRC61_uc003wgw.2_Intron	NM_138434	NP_612443	Q96FA7	CG029_HUMAN	hypothetical protein LOC113763	179										ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.011)			GCTGGCCTCTGAGAGAAGCGG	0.627													7	54					0	0	0	0	A	150028028	A	A	150028028	3	1	13	1	0	0	0	0	1	0	0	0	2396	1291	45	2	537	2	C7orf29	7	150028028	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	8262816	150028028	9110635	80	3004											
DPP6	1804	broad.mit.edu	37	chr7	154679393	154679393	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcttccgtgcagcctctgcGttttccgagaggtacttggg	4	13	13	11	3	1	1	0	0	1	1	3	2	3	1	3	2	5	4	3	2	1	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr7:154679393G>A	uc003wlk.2	+	23	2382	c.2253G>A	c.(2251-2253)GCG>GCA	p.A751A	DPP6_uc003wli.2_Silent_p.A687A|DPP6_uc003wlm.2_Silent_p.A689A|DPP6_uc011kvq.1_Silent_p.A644A	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	751	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CAGCCTCTGCGTTTTCCGAGA	0.592													69	241					0	0	0	0	A	154679393	A	A	154679393	2	1	13	1	0	0	0	0	0	0	0	1	4752	1132	40	1		1	DPP6	7	154679393	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	4651365	154679393	4459270	81	3005											
TM7SF4	81501	broad.mit.edu	37	chr8	105367308	105367308	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagcatctttctaccccagCgtggagaggaagcgcatcca	10	8	10	13	2	3	1	1	0	2	1	4	3	4	2	3	2	4	2	3	2	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:105367308C>T	uc003ylx.1	+	3	1282	c.1233C>T	c.(1231-1233)AGC>AGT	p.S411S		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	411	Cytoplasmic.				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TCTACCCCAGCGTGGAGAGGA	0.438													36	242					0	0	0	0	T	105367308	T	T	105367308	2	4	13	1	0	0	0	0	0	0	0	1	16042	767	27	1		1	TM7SF4	8	105367308	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08		105367308	40996714	82	3006											
CSMD3	114788	broad.mit.edu	37	chr8	113599423	113599423	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagtggataatttggagacaGcaaaattccttcattattcg	13	13	9	6	1	1	1	1	0	0	1	3	4	2	2	1	2	1	1	1	2	4	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:113599423G>A	uc003ynu.2	-	23	3916	c.3757C>T	c.(3757-3759)CTG>TTG	p.L1253L	CSMD3_uc003yns.2_Silent_p.L525L|CSMD3_uc003ynt.2_Silent_p.L1213L|CSMD3_uc011lhx.1_Silent_p.L1149L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1253	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTTGGAGACAGCAAAATTCCT	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			29	222					0	0	0	0	A	113599423	A	A	113599423	2	1	13	1	0	0	0	0	0	0	0	1	3963	962	34	4		4	CSMD3	8	113599423	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	8232115	113599423	32764599	83	3007											
TRPS1	7227	broad.mit.edu	37	chr8	116599315	116599315	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccagacttctctccgccAgctggcgccccctgcaggaa	6	6	10	19	2	1	1	0	0	1	1	3	2	2	2	6	2	2	2	6	2	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:116599315A>C	uc003ynz.2	-	4	3033	c.2574T>G	c.(2572-2574)GCT>GCG	p.A858A	TRPS1_uc011lhy.1_Silent_p.A862A|TRPS1_uc003yny.2_Silent_p.A871A|TRPS1_uc010mcy.2_Silent_p.A858A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	858					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TCTCTCCGCCAGCTGGCGCCC	0.577									Langer-Giedion_syndrome				4	141					0	0	0	0	C	116599315	C	C	116599315	2	2	13	1	0	0	0	0	0	0	0	1	16660	175	7	5		5	TRPS1	8	116599315	Silent	SNP	A	TCGA-BA-5558-01A-01D-1512-08	2999892	116599315	29764707	84	3008											
HAS2	3037	broad.mit.edu	37	chr8	122641162	122641162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tataagtggctgatttgtctCtgcccatgacttcactgaag	9	14	9	9	0	2	3	1	3	1	0	3	3	2	3	1	1	1	1	1	1	3	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:122641162C>T	uc003yph.2	-	2	957	c.419G>A	c.(418-420)AGA>AAA	p.R140K		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	140	Cytoplasmic (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			TGATTTGTCTCTGCCCATGAC	0.443													86	434					0	0	0	0	T	122641162	T	T	122641162	3	4	13	1	0	0	0	0	1	0	0	0	7001	913	32	2	1251	2	HAS2	8	122641162	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	6041847	122641162	23722860	85	3009											
FER1L6	654463	broad.mit.edu	37	chr8	124975615	124975615	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatgcttctatctttcctgtCccctcagcttctccaaagag	7	14	6	14	0	4	1	1	0	3	1	7	2	6	1	4	0	2	2	4	0	2	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:124975615C>T	uc003yqw.2	+	3	380	c.174C>T	c.(172-174)GTC>GTT	p.V58V		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	58	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCTTTCCTGTCCCCTCAGCTT	0.368													111	123					0	0	0	0	T	124975615	T	T	124975615	2	4	13	1	0	0	0	0	0	0	0	1	5847	842	30	2		2	FER1L6	8	124975615	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	2334453	124975615	21388407	86	3010											
HSF1	3297	broad.mit.edu	37	chr8	145533469	145533469	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaatccaggtgtccaccctGaagagtgaagacataaagat	15	7	11	8	0	0	5	0	2	0	3	2	6	2	6	3	2	0	0	3	2	5	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr8:145533469G>A	uc003zbt.3	+	4	545	c.375G>A	c.(373-375)CTG>CTA	p.L125L	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	125						cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			TGTCCACCCTGAAGAGTGAAG	0.597													18	117					0	0	0	0	A	145533469	A	A	145533469	2	1	13	1	0	0	0	0	0	0	0	1	7434	1277	45	2		2	HSF1	8	145533469	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	20557854	145533469	830553	87	3011											
KIAA2026	158358	broad.mit.edu	37	chr9	5920675	5920675	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcttttagaaatagatacaGaacgtgtggctcctggtact	11	13	10	7	1	1	3	0	0	1	3	2	3	2	3	1	2	3	2	1	2	6	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:5920675G>C	uc003zjq.3	-	8	5537	c.5321C>G	c.(5320-5322)TCT>TGT	p.S1774C	KIAA2026_uc010mht.2_Missense_Mutation_p.S949C	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1774										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AATAGATACAGAACGTGTGGC	0.423													4	467					0	0	0	0	C	5920675	C	C	5920675	3	2	13	1	0	0	0	0	1	0	0	0	8309	942	33	2	994	2	KIAA2026	9	5920675	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08		5920675	135292756	88	3012											
SH3GL2	6456	broad.mit.edu	37	chr9	17791298	17791298	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacaagcaggcagtccagAtcctgcagcaagtcacggtc	12	5	10	14	1	1	1	1	0	0	1	4	1	3	1	3	2	3	4	3	2	2	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:17791298A>T	uc003zna.2	+	7	982	c.694A>T	c.(694-696)ATC>TTC	p.I232F	SH3GL2_uc011lmy.1_Missense_Mutation_p.I185F	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	232	BAR.|Potential.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		GGCAGTCCAGATCCTGCAGCA	0.433													34	131					0	0	0	0	T	17791298	T	T	17791298	3	4	13	1	0	0	0	0	1	0	0	0	14316	333	12	5	720	5	SH3GL2	9	17791298	Missense_Mutation	SNP	A	TCGA-BA-5558-01A-01D-1512-08	11870623	17791298	123422133	89	3013											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	12					0	0	0	0	A	21971120	A	A	21971120	4	1	13	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	4179822	21971120	119242311	90	3014											
C9orf11	54586	broad.mit.edu	37	chr9	27286284	27286284	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaggagggtcatcaacgaGattcccagcattattttgat	12	11	11	7	1	2	2	2	1	0	1	3	5	3	4	1	3	2	1	1	3	2	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:27286284G>C	uc003zql.2	-	7	642	c.558C>G	c.(556-558)ATC>ATG	p.I186M	C9orf11_uc011lnq.1_Missense_Mutation_p.I157M	NM_020641	NP_065692	Q9NQ60	AFAF_HUMAN	Acr formation associated factor isoform 1	186	Helical; (Potential).					acrosomal membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(39;7.39e-08)|Lung(218;1.26e-05)|LUSC - Lung squamous cell carcinoma(38;0.000106)		TCATCAACGAGATTCCCAGCA	0.458													7	20					0	0	0	0	C	27286284	C	C	27286284	3	2	13	1	0	0	0	0	1	0	0	0	2460	932	33	2	334	2	C9orf11	9	27286284	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	5315164	27286284	113927147	91	3015											
LINGO2	158038	broad.mit.edu	37	chr9	27949543	27949543	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacacataggttgctggccaCcaaactgcagggtgggctgt	9	8	13	11	0	0	0	0	0	0	0	0	0	0	0	2	4	3	4	2	4	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:27949543C>A	uc003zqu.1	-	2	1321	c.1127G>T	c.(1126-1128)GGT>GTT	p.G376V	LINGO2_uc010mjf.1_Missense_Mutation_p.G376V|LINGO2_uc003zqv.1_Missense_Mutation_p.G376V	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	376	LRRCT.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TTGCTGGCCACCAAACTGCAG	0.527													4	66					0.00024832	0.000258433	1	0	A	27949543	A	A	27949543	3	1	13	1	0	0	0	0	1	0	0	0	8857	507	18	4	697	4	LINGO2	9	27949543	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	663259	27949543	113263888	92	3016											
DBC1	1620	broad.mit.edu	37	chr9	121930223	121930223	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaggtcagtctcaaagctGatgaactgctcgctccgctc	8	10	9	14	2	2	2	2	2	1	0	7	2	4	2	2	1	3	4	2	1	2	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:121930223G>A	uc004bkc.2	-	8	1881	c.1425C>T	c.(1423-1425)ATC>ATT	p.I475I		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	475					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TCTCAAAGCTGATGAACTGCT	0.572													16	53					0	0	0	0	A	121930223	A	A	121930223	2	1	13	1	0	0	0	0	0	0	0	1	4264	1280	45	2		2	DBC1	9	121930223	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	93980680	121930223	19283208	93	3017											
GSN	2934	broad.mit.edu	37	chr9	124072998	124072998	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caggattcaagcacgtggtaCccaacgaggtggtggtgcag	10	7	15	9	2	1	0	1	0	0	0	1	2	1	1	1	5	4	3	1	5	3	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:124072998C>T	uc004blf.1	+	4	602	c.541C>T	c.(541-543)CCC>TCC	p.P181S	GSN_uc004bld.1_Missense_Mutation_p.P130S|GSN_uc010mvq.1_Missense_Mutation_p.P141S|GSN_uc010mvr.1_Missense_Mutation_p.P141S|GSN_uc010mvu.1_Missense_Mutation_p.P130S|GSN_uc010mvt.1_Missense_Mutation_p.P130S|GSN_uc010mvs.1_Missense_Mutation_p.P130S|GSN_uc004ble.1_Missense_Mutation_p.P130S|GSN_uc010mvv.1_Missense_Mutation_p.P130S|GSN_uc011lyh.1_Missense_Mutation_p.P147S|GSN_uc011lyi.1_Missense_Mutation_p.P130S|GSN_uc011lyj.1_Missense_Mutation_p.P154S|GSN_uc004blg.1_5'Flank	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	181					actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						GCACGTGGTACCCAACGAGGT	0.577													18	74					0	0	0	0	T	124072998	T	T	124072998	3	4	13	1	0	0	0	0	1	0	0	0	6864	507	18	4	583	4	GSN	9	124072998	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	2142775	124072998	17140433	94	3018											
GOLGA1	2800	broad.mit.edu	37	chr9	127684082	127684082	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgacatctgattggagttCatcaactcctcctgggtacg	9	12	10	10	1	3	2	2	2	1	0	5	4	5	3	2	2	2	2	2	2	2	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:127684082C>T	uc004bpc.2	-	9	993	c.651G>A	c.(649-651)ATG>ATA	p.M217I	GOLGA1_uc010mws.2_RNA|GOLGA1_uc010mwt.1_Missense_Mutation_p.M192I	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	217	Potential.					Golgi cisterna membrane				ovary(1)	1						GATTGGAGTTCATCAACTCCT	0.438													54	213					0	0	0	0	T	127684082	T	T	127684082	3	4	13	1	0	0	0	0	1	0	0	0	6588	826	29	2	1712	2	GOLGA1	9	127684082	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	3611084	127684082	13529349	95	3019											
NUP188	23511	broad.mit.edu	37	chr9	131745261	131745261	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtacagacctgtcgatagcaGactgtctcctgcccatcaca	10	9	8	14	1	2	2	1	0	1	2	4	3	2	2	3	0	3	2	3	0	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr9:131745261G>C	uc004bws.1	+	17	1772	c.1750G>C	c.(1750-1752)GAC>CAC	p.D584H	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	584					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						GTCGATAGCAGACTGTCTCCT	0.522													50	186					0	0	0	0	C	131745261	C	C	131745261	3	2	13	1	0	0	0	0	1	0	0	0	10812	942	33	2	1816	2	NUP188	9	131745261	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	4061179	131745261	9468170	96	3020											
CAMK1D	57118	broad.mit.edu	37	chr10	12866500	12866500	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctcaacaaaaacatccaCgagtccgtcagcgcccagat	13	5	7	16	3	2	1	2	0	0	1	4	2	4	1	4	0	3	0	4	0	3	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:12866500C>T	uc001ilo.2	+	9	1105	c.870C>T	c.(868-870)CAC>CAT	p.H290H	CAMK1D_uc001iln.2_Silent_p.H290H	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	290	Autoinhibitory domain (By similarity).					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		AAAACATCCACGAGTCCGTCA	0.517													7	42					0	0	0	0	T	12866500	T	T	12866500	2	4	13	1	0	0	0	0	0	0	0	1	2609	535	19	1		1	CAMK1D	10	12866500	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08		12866500	122668247	97	3021											
RHOBTB1	9886	broad.mit.edu	37	chr10	62670718	62670718	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgagagaaacactcacttCatcaacaacatcccgagaac	16	6	5	14	1	3	3	3	1	0	2	4	5	4	3	2	0	4	0	2	0	4	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:62670718C>T	uc001jli.2	-	5	661	c.223G>A	c.(223-225)GAA>AAA	p.E75K	RHOBTB1_uc001jlh.2_Missense_Mutation_p.E75K|RHOBTB1_uc001jlj.2_Missense_Mutation_p.E75K|RHOBTB1_uc001jlk.2_Missense_Mutation_p.E75K|RHOBTB1_uc009xpe.1_Missense_Mutation_p.E75K|RHOBTB1_uc001jlm.2_Missense_Mutation_p.E75K	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	75	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					ACACTCACTTCATCAACAACA	0.488													17	75					0	0	0	0	T	62670718	T	T	62670718	3	4	13	1	0	0	0	0	1	0	0	0	13398	835	29	2	1899	2	RHOBTB1	10	62670718	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	49804218	62670718	72864029	98	3022											
CCAR1	55749	broad.mit.edu	37	chr10	70520875	70520875	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtagaggaacaaaaagaaGaacagaaggagttagagaaa	24	3	12	2	0	0	5	0	0	0	5	0	8	0	7	0	2	2	2	0	2	10	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:70520875G>C	uc001joo.2	+	16	2151	c.2032G>C	c.(2032-2034)GAA>CAA	p.E678Q	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Missense_Mutation_p.E483Q|CCAR1_uc009xpx.1_Missense_Mutation_p.E652Q|CCAR1_uc001jon.1_Missense_Mutation_p.E624Q|CCAR1_uc010qiz.1_Missense_Mutation_p.E663Q|CCAR1_uc010qja.1_Missense_Mutation_p.E663Q|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	678	Glu-rich.				apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						ACAAAAAGAAGAACAGAAGGA	0.348													33	99					0	0	0	0	C	70520875	C	C	70520875	3	2	13	1	0	0	0	0	1	0	0	0	2742	943	33	2	2090	2	CCAR1	10	70520875	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	7850157	70520875	65013872	99	3023											
USP54	159195	broad.mit.edu	37	chr10	75331188	75331188	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagtacttaccttgagagcGcaaaagatgcaggaatctcc	14	8	10	9	1	1	2	0	1	1	2	2	5	1	3	2	1	4	3	2	1	6	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:75331188G>A	uc001juo.2	-	2	248	c.231C>T	c.(229-231)TGC>TGT	p.C77C	USP54_uc001jup.2_Silent_p.C77C|USP54_uc010qkl.1_Silent_p.C77C	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	77					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					CCTTGAGAGCGCAAAAGATGC	0.433													4	134					0	0	0	0	A	75331188	A	A	75331188	2	1	13	1	0	0	0	0	0	0	0	1	17153	1079	38	1		1	USP54	10	75331188	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	4810313	75331188	60203559	100	3024											
TM9SF3	56889	broad.mit.edu	37	chr10	98311125	98311125	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttgatggtctaaatacatctCcatgcacctgtttccatcca	10	14	5	12	0	2	1	0	1	2	0	5	1	4	1	4	1	2	2	4	1	3	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:98311125C>G	uc001kmm.3	-	7	1053	c.836G>C	c.(835-837)GGA>GCA	p.G279A	TM9SF3_uc010qot.1_Missense_Mutation_p.G279A|TM9SF3_uc001kmn.1_Missense_Mutation_p.G48A	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	279						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		AAATACATCTCCATGCACCTG	0.353													34	157					0	0	0	0	G	98311125	G	G	98311125	3	3	13	1	0	0	0	0	1	0	0	0	16045	855	30	2	969	2	TM9SF3	10	98311125	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	22979937	98311125	37223622	101	3025											
POLL	27343	broad.mit.edu	37	chr10	103344392	103344392	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaggcttatggaagctcttGagggcattgatggccttggc	8	11	14	8	0	1	2	0	2	1	0	1	3	1	3	1	5	1	3	1	5	2	4	rs41540413		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:103344392G>A	uc001ktg.1	-	4	1624	c.858C>T	c.(856-858)CTC>CTT	p.L286L	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_5'Flank|POLL_uc001kth.1_Intron|POLL_uc001kti.1_Silent_p.L286L|POLL_uc001ktj.1_Silent_p.L286L|POLL_uc001ktf.2_Intron|POLL_uc001ktk.1_Intron|POLL_uc010qqa.1_Intron|POLL_uc010qqb.1_Intron|POLL_uc001ktm.2_Silent_p.L286L|POLL_uc001ktl.2_Silent_p.L198L|POLL_uc010qqc.1_Intron|POLL_uc010qqd.1_Missense_Mutation_p.S144L	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	286					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GGAAGCTCTTGAGGGCATTGA	0.562								DNA_polymerases_(catalytic_subunits)					42	107					0	0	0	0	A	103344392	A	A	103344392	2	1	13	1	0	0	0	0	0	0	0	1	12260	1277	45	2		2	POLL	10	103344392	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	5033267	103344392	32190355	102	3026											
POLL	27343	broad.mit.edu	37	chr10	103344516	103344516	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattggtcgccttctggcttGagggctgtgcacagacccac	6	10	13	12	1	1	2	0	1	1	1	2	3	1	2	2	3	1	3	2	3	0	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:103344516G>C	uc001ktg.1	-	4	1500	c.734C>G	c.(733-735)TCA>TGA	p.S245*	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_5'Flank|POLL_uc001kth.1_Intron|POLL_uc001kti.1_Nonsense_Mutation_p.S245*|POLL_uc001ktj.1_Nonsense_Mutation_p.S245*|POLL_uc001ktf.2_Intron|POLL_uc001ktk.1_Intron|POLL_uc010qqa.1_Intron|POLL_uc010qqb.1_Intron|POLL_uc001ktm.2_Nonsense_Mutation_p.S245*|POLL_uc001ktl.2_Nonsense_Mutation_p.S157*|POLL_uc010qqc.1_Intron|POLL_uc010qqd.1_Missense_Mutation_p.Q103E	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	245					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		CTTCTGGCTTGAGGGCTGTGC	0.582								DNA_polymerases_(catalytic_subunits)					26	66					0	0	0	0	C	103344516	C	C	103344516	4	2	13	1	0	0	0	0	0	1	0	0	12260	1294	45	2	1013	2	POLL	10	103344516	Nonsense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	124	103344516	32190231	103	3027											
ACADSB	36	broad.mit.edu	37	chr10	124803982	124803982	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggagtctcaatgaaggtaGaataggaattgctgcacagg	14	8	14	5	0	1	2	1	1	1	1	2	4	1	4	0	4	2	3	0	4	6	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:124803982G>C	uc001lhb.2	+	7	998	c.881G>C	c.(880-882)AGA>ACA	p.R294T	ACADSB_uc010qub.1_Missense_Mutation_p.R192T	NM_001609	NP_001600	P45954	ACDSB_HUMAN	acyl-Coenzyme A dehydrogenase, short/branched	294	Substrate binding.				branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	AATGAAGGTAGAATAGGAATT	0.358													20	72					0	0	0	0	C	124803982	C	C	124803982	3	2	13	1	0	0	0	0	1	0	0	0	115	942	33	2	907	2	ACADSB	10	124803982	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	21459466	124803982	10730765	104	3028											
C10orf137	26098	broad.mit.edu	37	chr10	127414362	127414362	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcttcatggcctgctcccttCgaaatgccttcttcagtttc	5	15	7	14	1	3	0	2	0	1	0	6	1	4	0	3	1	2	3	3	1	1	5	rs150180630	byFrequency	TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr10:127414362C>T	uc001liq.1	+	6	1040	c.747C>T	c.(745-747)TTC>TTT	p.F249F	C10orf137_uc001lin.2_Silent_p.F249F|C10orf137_uc001lio.1_Silent_p.F249F|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CTGCTCCCTTCGAAATGCCTT	0.463													21	76					0	0	0	0	T	127414362	T	T	127414362	2	4	13	1	0	0	0	0	0	0	0	1	1600	883	31	1		1	C10orf137	10	127414362	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	2610380	127414362	8120385	105	3029											
OR52J3	119679	broad.mit.edu	37	chr11	5068023	5068023	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctgggtatcttctggtttGatgctcacgagattaactat	8	16	10	7	1	3	2	1	1	2	1	3	3	3	2	0	2	3	4	0	2	3	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:5068023G>C	uc010qyv.1	+	1	268	c.268G>C	c.(268-270)GAT>CAT	p.D90H		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTCTGGTTTGATGCTCACGA	0.498													19	112					0	0	0	0	C	5068023	C	C	5068023	3	2	13	1	0	0	0	0	1	0	0	0	11176	1290	45	2	270	2	OR52J3	11	5068023	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08		5068023	129938493	106	3030											
KIF18A	81930	broad.mit.edu	37	chr11	28104463	28104463	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcttggtcattttcattaGtgaaggctttctgttcttca	6	20	8	7	0	5	1	3	1	2	0	5	1	5	1	0	2	1	3	0	2	2	8			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:28104463G>C	uc001msc.2	-	9	1384	c.1202C>G	c.(1201-1203)ACT>AGT	p.T401S		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	401	Potential.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						ATTTTCATTAGTGAAGGCTTT	0.279													23	75					0	0	0	0	C	28104463	C	C	28104463	3	2	13	1	0	0	0	0	1	0	0	0	8319	1029	36	4	1530	4	KIF18A	11	28104463	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	23036440	28104463	106902053	107	3031											
APLNR	187	broad.mit.edu	37	chr11	57004030	57004030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcacccaaagaactgccGtggccacggccccgctgacc	9	3	10	19	3	0	2	0	1	0	1	0	2	0	2	7	2	3	2	7	2	2	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:57004030G>A	uc001njo.2	-	1	898	c.449C>T	c.(448-450)ACG>ATG	p.T150M	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	150	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						AAGAACTGCCGTGGCCACGGC	0.647													5	33					0	0	0	0	A	57004030	A	A	57004030	3	1	13	1	0	0	0	0	1	0	0	0	777	1145	40	1	697	1	APLNR	11	57004030	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	28899567	57004030	78002486	108	3032											
VWCE	220001	broad.mit.edu	37	chr11	61039224	61039224	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaaccccgttgtcgtcaaGagagcagcctggatgaggac	10	7	12	12	2	2	2	2	1	0	1	3	5	2	4	3	2	3	2	3	2	2	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:61039224G>C	uc001nra.2	-	14	1987	c.1708C>G	c.(1708-1710)CTT>GTT	p.L570V	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	570	VWFC 4.					extracellular region	calcium ion binding			ovary(1)	1						TTGTCGTCAAGAGAGCAGCCT	0.498													2	16					0	0	0	0	C	61039224	C	C	61039224	3	2	13	1	0	0	0	0	1	0	0	0	17313	942	33	2	1187	2	VWCE	11	61039224	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	4035194	61039224	73967292	109	3033											
LGALS12	85329	broad.mit.edu	37	chr11	63283757	63283757	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagggagggctgaagctggcGctcaatgggcaggggctggg	7	5	22	7	1	1	1	1	1	0	0	1	3	1	2	0	7	1	5	0	7	2	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:63283757G>A	uc001nxa.2	+	9	1244	c.903G>A	c.(901-903)GCG>GCA	p.A301A	LGALS12_uc001nxb.2_Silent_p.A292A|LGALS12_uc001nxc.2_Silent_p.A302A|LGALS12_uc001nxd.2_Silent_p.A240A|LGALS12_uc001nxe.2_Silent_p.A231A|LGALS12_uc009yot.2_Silent_p.A261A	NM_033101	NP_149092	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12 isoform	301	Galectin 2.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			ovary(2)	2						TGAAGCTGGCGCTCAATGGGC	0.632													19	50					0	0	0	0	A	63283757	A	A	63283757	2	1	13	1	0	0	0	0	0	0	0	1	8779	1074	38	1		1	LGALS12	11	63283757	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	2244533	63283757	71722759	110	3034											
PYGM	5837	broad.mit.edu	37	chr11	64519416	64519416	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttgtacagggtgatgacaTggaggcagttgaggagctgt	9	10	18	4	0	0	3	0	3	0	0	0	5	0	5	0	5	2	5	0	5	1	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:64519416T>A	uc001oax.3	-	14	2565	c.1748A>T	c.(1747-1749)CAT>CTT	p.H583L	PYGM_uc001oay.3_Missense_Mutation_p.H495L	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	583					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	GGTGATGACATGGAGGCAGTT	0.502													20	95					0	0	0	0	A	64519416	A	A	64519416	3	1	13	1	0	0	0	0	1	0	0	0	12927	1464	51	5	808	5	PYGM	11	64519416	Missense_Mutation	SNP	T	TCGA-BA-5558-01A-01D-1512-08	1235659	64519416	70487100	111	3035											
CCDC67	159989	broad.mit.edu	37	chr11	93148192	93148192	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatgactgtgagccaaacaGaagtacaatgcctcccttgc	12	9	8	12	0	1	3	1	2	0	1	2	3	2	3	3	0	5	1	3	0	4	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:93148192G>A	uc001pdq.2	+	13	1650	c.1550G>A	c.(1549-1551)AGA>AAA	p.R517K	CCDC67_uc001pdo.1_Missense_Mutation_p.R517K	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	517										ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				GAGCCAAACAGAAGTACAATG	0.398													91	113					0	0	0	0	A	93148192	A	A	93148192	3	1	13	1	0	0	0	0	1	0	0	0	2852	942	33	2	1596	2	CCDC67	11	93148192	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	28628776	93148192	41858324	112	3036											
C11orf88	399949	broad.mit.edu	37	chr11	111385713	111385713	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagcgtctgccggtggcgcgGcccaggaggagcagagggtc	6	4	19	12	4	1	1	0	0	1	1	2	3	1	3	2	6	3	1	2	6	0	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr11:111385713G>C	uc001pln.3	+	1	204	c.204G>C	c.(202-204)CGG>CGC	p.R68R	BTG4_uc001plj.2_5'Flank|BTG4_uc001plk.2_5'Flank|C11orf88_uc009yyd.2_Silent_p.R68R|C11orf88_uc001plo.1_Silent_p.R68R	NM_001100388	NP_001093858	Q6PI97	CK088_HUMAN	hypothetical protein LOC399949 isoform 2	68											0						CGGTGGCGCGGCCCAGGAGGA	0.602											OREG0021329	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	70					0	0	0	0	C	111385713	C	C	111385713	2	2	13	1	0	0	0	0	0	0	0	1	1676	1190	42	4		4	C11orf88	11	111385713	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	18237521	111385713	23620803	113	3037											
SLC6A13	6540	broad.mit.edu	37	chr12	333247	333247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcttcttgcggaacacgtGagggtacatgtccaccagcg	8	10	12	11	3	2	1	0	1	2	0	3	2	3	2	2	2	4	2	2	2	2	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:333247G>A	uc001qic.1	-	11	1275	c.1222C>T	c.(1222-1224)CAC>TAC	p.H408Y	SLC6A13_uc009zdj.1_Missense_Mutation_p.H398Y|SLC6A13_uc010sdl.1_Missense_Mutation_p.H316Y	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	408					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CGGAACACGTGAGGGTACATG	0.562													25	61					0	0	0	0	A	333247	A	A	333247	3	1	13	1	0	0	0	0	1	0	0	0	14740	1290	45	2	606	2	SLC6A13	12	333247	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08		333247	133518648	114	3038											
CHD4	1108	broad.mit.edu	37	chr12	6691446	6691446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	catgaaaagagagacatatgCcctgtgtaaagaagtagaga	18	7	11	5	0	0	5	0	1	0	4	0	7	0	5	1	0	1	2	1	0	7	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:6691446C>T	uc001qpo.2	-	30	4536	c.4372G>A	c.(4372-4374)GCA>ACA	p.A1458T	CHD4_uc001qpn.2_Missense_Mutation_p.A1451T|CHD4_uc001qpp.2_Missense_Mutation_p.A1483T|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1458					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GAGACATATGCCCTGTGTAAA	0.488													21	70					0	0	0	0	T	6691446	T	T	6691446	3	4	13	1	0	0	0	0	1	0	0	0	3342	753	26	4	1410	4	CHD4	12	6691446	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	6358199	6691446	127160449	115	3039											
ATN1	1822	broad.mit.edu	37	chr12	7045557	7045557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccatgaggtttccttattCatcctctagtagtagctctg	7	15	7	12	0	3	1	1	1	2	0	5	1	5	1	4	1	1	4	4	1	4	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:7045557C>T	uc001qrw.1	+	5	1364	c.1127C>T	c.(1126-1128)TCA>TTA	p.S376L	ATN1_uc001qrx.1_Missense_Mutation_p.S376L|ATN1_uc001qry.1_Missense_Mutation_p.S375L	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	376	Poly-Ser.				cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TTTCCTTATTCATCCTCTAGT	0.463													44	134					0	0	0	0	T	7045557	T	T	7045557	3	4	13	1	0	0	0	0	1	0	0	0	1113	838	29	2	1141	2	ATN1	12	7045557	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	354111	7045557	126806338	116	3040											
MLL2	8085	broad.mit.edu	37	chr12	49434325	49434325	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaggactggcaggcactcGggagaaagggtcggagggca	10	4	19	8	2	0	2	0	1	0	1	2	5	0	4	0	7	0	3	0	7	1	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:49434325G>A	uc001rta.3	-	31	7228	c.7228C>T	c.(7228-7230)CGA>TGA	p.R2410*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2410	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCAGGCACTCGGGAGAAAGGG	0.647			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			8	41					0	0	0	0	A	49434325	A	A	49434325	4	1	13	1	0	0	0	0	0	1	0	0	9674	1124	39	1	9481	1	MLL2	12	49434325	Nonsense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	42388768	49434325	84417570	117	3041											
ESPL1	9700	broad.mit.edu	37	chr12	53680494	53680494	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggcgccaaaagttagcctCtgctcccctgcgcctcaata	9	8	9	15	2	2	0	1	0	1	0	3	0	3	0	5	1	3	2	5	1	5	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:53680494C>T	uc001sck.2	+	18	4065	c.3974C>T	c.(3973-3975)TCT>TTT	p.S1325F	ESPL1_uc001scj.2_Missense_Mutation_p.S1000F|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1325					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						AAGTTAGCCTCTGCTCCCCTG	0.562													16	49					0	0	0	0	T	53680494	T	T	53680494	3	4	13	1	0	0	0	0	1	0	0	0	5277	913	32	2	4040	2	ESPL1	12	53680494	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	4246169	53680494	80171401	118	3042											
ARHGAP9	64333	broad.mit.edu	37	chr12	57872434	57872434	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agattgtcagtgctgacgctCctacacattttgcggggaag	9	11	12	9	2	1	2	1	1	0	1	2	3	2	3	1	2	3	2	1	2	2	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:57872434C>G	uc001sod.2	-	6	829	c.636G>C	c.(634-636)AGG>AGC	p.R212S	ARHGAP9_uc001snz.2_5'Flank|ARHGAP9_uc001soa.2_5'Flank|ARHGAP9_uc001sob.2_Missense_Mutation_p.R141S|ARHGAP9_uc001soc.2_Missense_Mutation_p.R141S|ARHGAP9_uc001soe.1_Missense_Mutation_p.R220S|ARHGAP9_uc010sro.1_Missense_Mutation_p.R141S	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	141					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			TGCTGACGCTCCTACACATTT	0.577													38	158					0	0	0	0	G	57872434	G	G	57872434	3	3	13	1	0	0	0	0	1	0	0	0	889	854	30	2	1836	2	ARHGAP9	12	57872434	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	4191940	57872434	75979461	119	3043											
FAM19A2	338811	broad.mit.edu	37	chr12	62261196	62261196	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgttgctttctgtaagtatCtcttactcatcctgcaaata	9	18	5	9	0	3	0	1	0	2	0	5	0	4	0	1	0	3	5	1	0	5	7			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:62261196C>G	uc001sqw.2	-	2	1524	c.11G>C	c.(10-12)AGA>ACA	p.R4T	FAM19A2_uc001sqx.2_Missense_Mutation_p.R4T|FAM19A2_uc001sqy.2_RNA	NM_178539	NP_848634	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine	4						cytoplasm				ovary(1)	1			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		CTGTAAGTATCTCTTACTCAT	0.313													23	113					0	0	0	0	G	62261196	G	G	62261196	3	3	13	1	0	0	0	0	1	0	0	0	5560	913	32	2	400	2	FAM19A2	12	62261196	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	4388762	62261196	71590699	120	3044											
CPM	1368	broad.mit.edu	37	chr12	69250400	69250400	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttaagagcactgaagttCtgggatttctccggaataat	11	15	9	6	1	2	2	0	1	2	1	3	4	2	4	1	2	1	2	1	2	4	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:69250400C>T	uc001sup.2	-	9	1210	c.1149G>A	c.(1147-1149)CAG>CAA	p.Q383Q	CPM_uc001sur.2_Silent_p.Q383Q|CPM_uc001suq.2_Silent_p.Q383Q	NM_198320	NP_938079	P14384	CBPM_HUMAN	carboxypeptidase M precursor	383					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding				0	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			CACTGAAGTTCTGGGATTTCT	0.393													32	124					0	0	0	0	T	69250400	T	T	69250400	2	4	13	1	0	0	0	0	0	0	0	1	3823	912	32	2		2	CPM	12	69250400	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	6989204	69250400	64601495	121	3045											
CDK17	5128	broad.mit.edu	37	chr12	96691104	96691104	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccatgtactgtttcaggtCtttatcctggaaaaacacag	12	13	7	9	0	2	0	1	0	1	0	4	1	4	1	2	2	2	2	2	2	4	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:96691104C>G	uc001tep.1	-	9	1306	c.817G>C	c.(817-819)GAC>CAC	p.D273H	CDK17_uc009ztk.2_Missense_Mutation_p.D273H|CDK17_uc010svb.1_Missense_Mutation_p.D220H	NM_002595	NP_002586	Q00537	CDK17_HUMAN	PCTAIRE protein kinase 2	273	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			ovary(3)|lung(2)|kidney(1)|central_nervous_system(1)	7						TGTTTCAGGTCTTTATCCTGG	0.338													9	67					0	0	0	0	G	96691104	G	G	96691104	3	3	13	1	0	0	0	0	1	0	0	0	3148	913	32	2	828	2	CDK17	12	96691104	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	27440704	96691104	37160791	122	3046											
MYBPC1	4604	broad.mit.edu	37	chr12	102046500	102046500	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgccctcactgaagatgaagGtgattatgtatttgcacctg	10	13	10	8	0	1	4	1	3	0	1	1	4	1	4	2	1	2	2	2	1	4	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:102046500G>C	uc001tii.2	+	15	1598	c.1496G>C	c.(1495-1497)GGT>GCT	p.G499A	MYBPC1_uc001tig.2_Missense_Mutation_p.G524A|MYBPC1_uc010svq.1_Missense_Mutation_p.G486A|MYBPC1_uc001tih.2_Missense_Mutation_p.G524A|MYBPC1_uc001tij.2_Missense_Mutation_p.G499A|MYBPC1_uc010svr.1_Missense_Mutation_p.G499A|MYBPC1_uc010svs.1_Missense_Mutation_p.G499A|MYBPC1_uc010svt.1_Missense_Mutation_p.G487A|MYBPC1_uc010svu.1_Missense_Mutation_p.G480A|MYBPC1_uc001tik.2_Missense_Mutation_p.G473A	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	499	Ig-like C2-type 4.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GAAGATGAAGGTGATTATGTA	0.358													54	199					0	0	0	0	C	102046500	C	C	102046500	3	2	13	1	0	0	0	0	1	0	0	0	10064	1261	44	4	1637	4	MYBPC1	12	102046500	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	5355396	102046500	31805395	123	3047											
STAB2	55576	broad.mit.edu	37	chr12	104064480	104064480	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctttgctcccagtgtgcaGatagcctcggcggcaacggg	6	8	14	13	3	0	1	0	0	0	1	2	1	1	1	3	3	4	3	3	3	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:104064480G>C	uc001tjw.2	+	22	2452	c.2266G>C	c.(2266-2268)GAT>CAT	p.D756H		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	756	Extracellular (Potential).|EGF-like 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCAGTGTGCAGATAGCCTCGG	0.502													11	28					0	0	0	0	C	104064480	C	C	104064480	3	2	13	1	0	0	0	0	1	0	0	0	15304	942	33	2	2352	2	STAB2	12	104064480	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	2017980	104064480	29787415	124	3048											
CKAP4	10970	broad.mit.edu	37	chr12	106633144	106633144	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctcgcccacactcctcttCagctcctccacgtcaccgta	7	9	5	20	3	3	0	2	0	1	0	7	0	6	0	5	0	2	3	5	0	1	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:106633144C>T	uc001tlk.2	-	2	1551	c.1467G>A	c.(1465-1467)CTG>CTA	p.L489L		NM_006825	NP_006816	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	489						ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction					0						CACTCCTCTTCAGCTCCTCCA	0.662													32	89					0	0	0	0	T	106633144	T	T	106633144	2	4	13	1	0	0	0	0	0	0	0	1	3459	813	29	2		2	CKAP4	12	106633144	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	2568664	106633144	27218751	125	3049											
SFRS8	6433	broad.mit.edu	37	chr12	132195869	132195869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccggcggtgggggcagccGagtggagctcttggttttcg	3	10	19	9	4	1	0	0	0	1	0	2	2	1	1	2	6	3	3	2	6	0	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr12:132195869G>A	uc001uja.1	+	1	235	c.95G>A	c.(94-96)CGA>CAA	p.R32Q	SFRS8_uc010tbn.1_Missense_Mutation_p.R32Q|SFRS8_uc001ujb.1_5'UTR|SFRS8_uc001uiz.1_5'UTR	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	32					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		GGGGGCAGCCGAGTGGAGCTC	0.697													8	32					0	0	0	0	A	132195869	A	A	132195869	3	1	13	1	0	0	0	0	1	0	0	0	14248	1058	37	1	97	1	SFRS8	12	132195869	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	25562725	132195869	1656026	126	3050											
SLC7A1	6541	broad.mit.edu	37	chr13	30096553	30096553	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtccatcctcagccatggCatagataacccgaggcatgg	11	7	10	13	1	1	1	1	0	0	1	3	2	3	1	4	3	2	2	4	3	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr13:30096553C>G	uc001uso.2	-	8	1477	c.1090G>C	c.(1090-1092)GCC>CCC	p.A364P		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	364	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TCAGCCATGGCATAGATAACC	0.498													30	150					0	0	0	0	G	30096553	G	G	30096553	3	3	13	1	0	0	0	0	1	0	0	0	14756	710	25	4	823	4	SLC7A1	13	30096553	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08		30096553	85073325	127	3051											
PCDH9	5101	broad.mit.edu	37	chr13	67800883	67800883	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggggctattgtcattctcatCcagaacagtaacaatcacag	13	10	8	10	0	3	1	3	0	1	1	5	1	4	1	1	2	2	2	1	2	4	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr13:67800883C>A	uc001vik.2	-	2	2382	c.1690G>T	c.(1690-1692)GAT>TAT	p.D564Y	PCDH9_uc001vil.2_Missense_Mutation_p.D564Y|PCDH9_uc010thl.1_Missense_Mutation_p.D564Y|PCDH9_uc001vin.3_Missense_Mutation_p.D564Y	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	564	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TCATTCTCATCCAGAACAGTA	0.428													33	155					1.74807e-11	1.89649e-11	1	0	A	67800883	A	A	67800883	3	1	13	1	0	0	0	0	1	0	0	0	11572	855	30	2	2039	2	PCDH9	13	67800883	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	37704330	67800883	47368995	128	3052											
RBM26	64062	broad.mit.edu	37	chr13	79933752	79933752	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taggaactccaggctctccaGaaccaatggttcttttcctt	9	13	7	12	0	2	1	0	0	2	1	5	2	4	2	4	3	2	2	4	3	4	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr13:79933752G>A	uc001vkz.2	-	10	1516	c.1502C>T	c.(1501-1503)TCT>TTT	p.S501F	RBM26_uc001vky.2_Missense_Mutation_p.S496F|RBM26_uc001vla.2_Missense_Mutation_p.S496F|RBM26_uc001vkx.2_Missense_Mutation_p.S208F	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	496					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		AGGCTCTCCAGAACCAATGGT	0.363													70	202					0	0	0	0	A	79933752	A	A	79933752	3	1	13	1	0	0	0	0	1	0	0	0	13191	942	33	2	1503	2	RBM26	13	79933752	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	12132869	79933752	35236126	129	3053											
TGDS	23483	broad.mit.edu	37	chr13	95233394	95233394	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacattcagcagctgctttaGatgatgcataaggatttgta	13	13	9	6	0	1	2	1	1	0	1	1	3	1	3	0	1	5	5	0	1	4	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr13:95233394G>C	uc001vlw.2	-	6	627	c.506C>G	c.(505-507)TCT>TGT	p.S169C	TGDS_uc001vlx.2_RNA	NM_014305	NP_055120	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase	169					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					AGCTGCTTTAGATGATGCATA	0.299													16	77					0	0	0	0	C	95233394	C	C	95233394	3	2	13	1	0	0	0	0	1	0	0	0	15880	942	33	2	574	2	TGDS	13	95233394	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	15299642	95233394	19936484	130	3054											
HOMEZ	57594	broad.mit.edu	37	chr14	23745733	23745733	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtgactggttgggacccCtgcctgcctgctcctttgag	4	12	12	13	0	0	2	0	2	0	0	1	3	1	3	5	2	3	2	5	2	0	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr14:23745733C>T	uc001wja.2	-	2	852	c.704G>A	c.(703-705)AGG>AAG	p.R235K	HOMEZ_uc001wjb.2_Missense_Mutation_p.R237K	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	235						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GTTGGGACCCCTGCCTGCCTG	0.542													37	105					0	0	0	0	T	23745733	T	T	23745733	3	4	13	1	0	0	0	0	1	0	0	0	7320	681	24	4	952	4	HOMEZ	14	23745733	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08		23745733	83603807	131	3055											
SLC22A17	51310	broad.mit.edu	37	chr14	23816792	23816792	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagagaagaaggatgccccGgcggccaaatcggtccacgg	11	3	16	11	4	0	2	0	0	0	2	2	5	1	4	4	6	1	0	4	6	3	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr14:23816792G>A	uc001wjl.2	-	7	1149	c.1093C>T	c.(1093-1095)CGG>TGG	p.R365W	SLC22A17_uc010akk.2_Missense_Mutation_p.R147W|SLC22A17_uc001wjn.2_RNA|SLC22A17_uc001wjm.2_Missense_Mutation_p.R365W	NM_020372	NP_065105	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17 isoform a	365					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity				0	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		AGGATGCCCCGGCGGCCAAAT	0.632													24	62					0	0	0	0	A	23816792	A	A	23816792	3	1	13	1	0	0	0	0	1	0	0	0	14513	1115	39	1	535	1	SLC22A17	14	23816792	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	71059	23816792	83532748	132	3056											
CLMN	79789	broad.mit.edu	37	chr14	95670229	95670229	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtcaccagcgaccttgtcaGaggaggattctggaatcttc	9	11	11	10	1	4	1	2	0	2	1	5	5	4	4	2	3	1	0	2	3	1	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr14:95670229G>A	uc001yef.2	-	9	1573	c.1457C>T	c.(1456-1458)TCT>TTT	p.S486F		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	486						integral to membrane	actin binding				0				Epithelial(152;0.193)		GACCTTGTCAGAGGAGGATTC	0.468													25	50					0	0	0	0	A	95670229	A	A	95670229	3	1	13	1	0	0	0	0	1	0	0	0	3557	942	33	2	1571	2	CLMN	14	95670229	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	71853437	95670229	11679311	133	3057											
C14orf49	161176	broad.mit.edu	37	chr14	95906119	95906119	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tccgggaattctgccaccagCctctaaaggacacacggaca	12	6	9	14	2	2	0	0	0	2	0	3	3	3	3	4	3	2	0	4	3	3	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr14:95906119C>A	uc001yei.3	-	12	2091	c.2076G>T	c.(2074-2076)AGG>AGT	p.R692S	C14orf49_uc010avi.2_Missense_Mutation_p.R692S	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	692	Spectrin 2.|Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		CTGCCACCAGCCTCTAAAGGA	0.607													24	63					3.01185e-09	3.22198e-09	1	0	A	95906119	A	A	95906119	3	1	13	1	0	0	0	0	1	0	0	0	1782	738	26	4	875	4	C14orf49	14	95906119	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	235890	95906119	11443421	134	3058											
PACS2	23241	broad.mit.edu	37	chr14	105850745	105850745	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gactaccgctacaacaacttCttccaggacctggcctggag	10	8	9	14	1	1	0	0	0	1	0	2	3	2	2	4	3	4	1	4	3	4	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr14:105850745C>G	uc001yqt.2	+	17	1999	c.1824C>G	c.(1822-1824)TTC>TTG	p.F608L	PACS2_uc001yqs.2_Missense_Mutation_p.F533L|PACS2_uc001yqv.2_Missense_Mutation_p.F612L|PACS2_uc001yqu.2_Missense_Mutation_p.F612L	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	608					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		ACAACAACTTCTTCCAGGACC	0.677													12	35					0	0	0	0	G	105850745	G	G	105850745	3	3	13	1	0	0	0	0	1	0	0	0	11427	912	32	2	1902	2	PACS2	14	105850745	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	9944626	105850745	1498795	135	3059											
RASL12	51285	broad.mit.edu	37	chr15	65357567	65357567	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcttacccaagttggggtCatattcactgataaacctct	10	15	6	10	0	4	1	2	1	2	0	4	1	4	1	2	2	2	1	2	2	5	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr15:65357567C>T	uc002aoi.1	-	2	363	c.148G>A	c.(148-150)GAC>AAC	p.D50N	RASL12_uc002aoj.1_Intron|RASL12_uc010uir.1_Missense_Mutation_p.D39N	NM_016563	NP_057647	Q9NYN1	RASLC_HUMAN	RAS-like, family 12 protein	50					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			skin(1)	1						AAGTTGGGGTCATATTCACTG	0.572													8	20					0	0	0	0	T	65357567	T	T	65357567	3	4	13	1	0	0	0	0	1	0	0	0	13148	826	29	2	668	2	RASL12	15	65357567	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08		65357567	37173825	136	3060											
WHAMM	123720	broad.mit.edu	37	chr15	83495204	83495204	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttcagattgcaacaggctGaagaaagcataagatactct	15	9	10	7	0	2	4	1	1	1	3	2	4	2	4	0	2	4	4	0	2	5	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr15:83495204G>A	uc002bje.2	+	7	2007	c.1501G>A	c.(1501-1503)GAA>AAA	p.E501K		NM_001080435	NP_001073904	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi	501						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding				0						GCAACAGGCTGAAGAAAGCAT	0.408													37	133					0	0	0	0	A	83495204	A	A	83495204	3	1	13	1	0	0	0	0	1	0	0	0	17429	1291	45	2	1527	2	WHAMM	15	83495204	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	18137637	83495204	19036188	137	3061											
ZNF592	9640	broad.mit.edu	37	chr15	85341666	85341666	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtgccctgagtgcccactCttgttcgtgcagaagccgga	8	9	12	12	2	1	2	0	1	1	1	2	3	1	3	3	1	4	2	3	1	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr15:85341666C>G	uc002bld.2	+	7	3033	c.2697C>G	c.(2695-2697)CTC>CTG	p.L899L	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	899	C2H2-type 8.				cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGTGCCCACTCTTGTTCGTGC	0.567													29	60					0	0	0	0	G	85341666	G	G	85341666	2	3	13	1	0	0	0	0	0	0	0	1	18089	900	32	2		2	ZNF592	15	85341666	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	1846462	85341666	17189726	138	3062											
AGBL1	123624	broad.mit.edu	37	chr15	87097594	87097594	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttgtttttactgtagacTcttcccaaaatccttgataa	10	19	4	8	0	1	2	0	1	1	1	3	2	3	2	2	0	1	2	2	0	5	9			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr15:87097594T>C	uc002blz.1	+	20	2762	c.2682T>C	c.(2680-2682)ACT>ACC	p.T894T		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	894					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TACTGTAGACTCTTCCCAAAA	0.398													4	7					0	0	0	0	C	87097594	C	C	87097594	2	2	13	1	0	0	0	0	0	0	0	1	375	1538	54	5		5	AGBL1	15	87097594	Silent	SNP	T	TCGA-BA-5558-01A-01D-1512-08	1755928	87097594	15433798	139	3063											
WDR90	197335	broad.mit.edu	37	chr16	711778	711778	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcagcgtggggcagacatCagccttcaggtgccacccgt	8	6	13	14	2	2	1	2	0	0	1	2	1	2	1	3	3	4	2	3	3	0	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:711778C>T	uc002cii.1	+	31	3909	c.3855C>T	c.(3853-3855)ATC>ATT	p.I1285I	WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Silent_p.I812I|WDR90_uc002cil.1_RNA|WDR90_uc002cim.1_Silent_p.I459I|WDR90_uc002cin.1_5'UTR	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1285	WD 14.									ovary(1)	1		Hepatocellular(780;0.0218)				GGGCAGACATCAGCCTTCAGG	0.647													32	101					0	0	0	0	T	711778	T	T	711778	2	4	13	1	0	0	0	0	0	0	0	1	17405	816	29	2		2	WDR90	16	711778	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08		711778	89642975	140	3064											
WDR90	197335	broad.mit.edu	37	chr16	716485	716485	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taggggtggagggcacagacCtatggctggctgccagtggg	7	7	19	8	0	0	1	0	0	0	1	0	2	0	2	2	7	1	3	2	7	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:716485C>T	uc002cii.1	+	38	4825	c.4771C>T	c.(4771-4773)CTA>TTA	p.L1591L	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Silent_p.L206L|WDR90_uc010uul.1_Intron|WDR90_uc002cio.1_Silent_p.L190L|WDR90_uc010bqx.1_Intron|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1591	WD 20.									ovary(1)	1		Hepatocellular(780;0.0218)				GGGCACAGACCTATGGCTGGC	0.632													13	36					0	0	0	0	T	716485	T	T	716485	2	4	13	1	0	0	0	0	0	0	0	1	17405	680	24	4		4	WDR90	16	716485	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	4707	716485	89638268	141	3065											
GLYR1	84656	broad.mit.edu	37	chr16	4863755	4863755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgggccagctcagtgaCggtgtcagcgtccactgttg	6	10	13	12	2	2	1	2	1	0	0	3	1	3	1	3	2	3	2	3	2	1	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:4863755C>T	uc002cxx.3	-	12	1139	c.1102G>A	c.(1102-1104)GTC>ATC	p.V368I	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Missense_Mutation_p.V282I|GLYR1_uc002cya.2_Missense_Mutation_p.V362I|GLYR1_uc010uxv.1_Missense_Mutation_p.V287I	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	368					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						AGCTCAGTGACGGTGTCAGCG	0.592													6	29					0	0	0	0	T	4863755	T	T	4863755	3	4	13	1	0	0	0	0	1	0	0	0	6520	536	19	1	579	1	GLYR1	16	4863755	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	4147270	4863755	85490998	142	3066											
TMC7	79905	broad.mit.edu	37	chr16	19063127	19063127	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaataatacctctgacaatCagcatatcacggtaaatgtg	15	10	7	9	1	3	1	2	1	1	0	3	1	3	1	1	1	2	3	1	1	7	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:19063127C>G	uc002dfq.2	+	13	1990	c.1860C>G	c.(1858-1860)ATC>ATG	p.I620M	TMC7_uc002dfp.2_Missense_Mutation_p.I620M|TMC7_uc010vap.1_Missense_Mutation_p.I510M	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	620	Helical; (Potential).					integral to membrane				skin(2)|ovary(1)	3						CTCTGACAATCAGCATATCAC	0.413													70	316					0	0	0	0	G	19063127	G	G	19063127	3	3	13	1	0	0	0	0	1	0	0	0	16056	816	29	2	1910	2	TMC7	16	19063127	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	14199372	19063127	71291626	143	3067											
SEPHS2	22928	broad.mit.edu	37	chr16	30456439	30456439	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactgccgtccctccttcctCagccgcatcccgaaagcctt	6	9	6	20	3	1	0	1	0	0	0	5	1	5	0	7	0	3	1	7	0	1	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:30456439C>T	uc010ves.1	-	2	786	c.610G>A	c.(610-612)GAG>AAG	p.E204K	SEPHS2_uc002dyh.1_Missense_Mutation_p.E147K|SEPHS2_uc010vet.1_Missense_Mutation_p.E86K	NM_012248	NP_036380	Q99611	SPS2_HUMAN	selenophosphate synthetase 2	204					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(2)	2						CCTCCTTCCTCAGCCGCATCC	0.517													34	106					0	0	0	0	T	30456439	T	T	30456439	3	4	13	1	0	0	0	0	1	0	0	0	14120	835	29	2	740	2	SEPHS2	16	30456439	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	11393312	30456439	59898314	144	3068											
SETD1A	9739	broad.mit.edu	37	chr16	30976423	30976423	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagggcccagccctgagagaGaagaagttcggacttccccc	10	5	13	13	1	0	3	0	1	0	3	2	7	1	4	4	2	1	1	4	2	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:30976423G>A	uc002ead.1	+	7	2046	c.1360G>A	c.(1360-1362)GAA>AAA	p.E454K		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	454	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CCCTGAGAGAGAAGAAGTTCG	0.697													11	41					0	0	0	0	A	30976423	A	A	30976423	3	1	13	1	0	0	0	0	1	0	0	0	14195	943	33	2	1382	2	SETD1A	16	30976423	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	519984	30976423	59378330	145	3069											
RPGRIP1L	23322	broad.mit.edu	37	chr16	53730193	53730193	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcgagacttcattgtccGtgttgttgaagtttctgcaa	7	15	11	8	2	2	2	1	1	1	1	3	3	3	2	1	1	1	4	1	1	2	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:53730193G>A	uc002ehp.2	-	3	164	c.100C>T	c.(100-102)CGG>TGG	p.R34W	RPGRIP1L_uc002eho.3_Missense_Mutation_p.R34W|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.R34W|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.R34W|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.R34W|RPGRIP1L_uc002ehq.1_Missense_Mutation_p.R34W|RPGRIP1L_uc010cby.1_Missense_Mutation_p.R34W	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	34					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TTCATTGTCCGTGTTGTTGAA	0.373													65	230					0	0	0	0	A	53730193	A	A	53730193	3	1	13	1	0	0	0	0	1	0	0	0	13615	1144	40	1	3947	1	RPGRIP1L	16	53730193	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	22753770	53730193	36624560	146	3070											
ZNF319	57567	broad.mit.edu	37	chr16	58031982	58031982	+	Frame_Shift_Del	DEL	G	-	-																															cctgcaggggtgcgtgttgtGggggctgcaggccggggtct																										TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:58031982delG	uc002emx.1	-	2	811	c.188delC	c.(187-189)CCAfs	p.P63fs		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	63	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCGTGTTGTGGGGGCTGCAG	0.687													---	---	---								-	58031982	-	-	58031982	7	5	13	1	0	1	0	1	0	0	0	0	17904	1348	47	0	1564	0	ZNF319	16	58031982	Frame_Shift_Del	DEL	G	TCGA-BA-5558-01A-01D-1512-08	4301789	58031982	32322771	147	3071											
CNOT1	23019	broad.mit.edu	37	chr16	58608533	58608533	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgcacaagcttgcagacaGgccaacattgtcgccaaagt	12	7	9	13	1	0	1	0	0	0	1	1	1	0	1	3	1	4	3	3	1	3	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:58608533G>C	uc002env.2	-	16	2252	c.1959C>G	c.(1957-1959)GCC>GCG	p.A653A	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.A653A|CNOT1_uc002enx.2_Silent_p.A653A|CNOT1_uc002enz.1_Silent_p.A82A	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	653					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CTTGCAGACAGGCCAACATTG	0.423													32	105					0	0	0	0	C	58608533	C	C	58608533	2	2	13	1	0	0	0	0	0	0	0	1	3632	987	35	4		4	CNOT1	16	58608533	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	576551	58608533	31746220	148	3072											
FUK	197258	broad.mit.edu	37	chr16	70513582	70513582	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctgttgccctttcccatGaagctggcttctctctgcaa	7	13	7	14	0	2	1	0	1	2	0	4	1	3	1	3	1	4	4	3	1	3	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr16:70513582G>A	uc002eyy.2	+	24	3312	c.3254G>A	c.(3253-3255)TGA>TAA	p.*1085*	FUK_uc010cft.2_Silent_p.*1091*|FUK_uc002eyz.2_Silent_p.*576*	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	1085						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				CCTTTCCCATGAAGCTGGCTT	0.592													13	45					0	0	0	0	A	70513582	A	A	70513582	2	1	13	1	0	0	0	0	0	0	0	1	6130	1285	45	2		2	FUK	16	70513582	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	11905049	70513582	19841171	149	3073											
AMAC1L3	643664	broad.mit.edu	37	chr17	7386198	7386198	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggcccttatactgcagtatTatatgctccatgagactgtg	9	14	9	9	0	0	1	0	1	0	1	1	2	1	1	2	1	3	3	2	1	5	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:7386198T>A	uc010cmj.1	+	2	1010	c.895T>A	c.(895-897)TAT>AAT	p.Y299N	ZBTB4_uc002ghd.3_Intron|POLR2A_uc002ghe.2_5'Flank|POLR2A_uc002ghf.3_5'Flank	NM_001102614	NP_001096084	P0C7Q6	AMCL3_HUMAN	acyl-malonyl condensing enzyme 1-like 3	299	DUF6 2.|Helical; (Potential).					integral to membrane					0		Prostate(122;0.173)				ACTGCAGTATTATATGCTCCA	0.577													55	170					0	0	0	0	A	7386198	A	A	7386198	3	1	13	1	0	0	0	0	1	0	0	0	561	1754	61	5	901	5	AMAC1L3	17	7386198	Missense_Mutation	SNP	T	TCGA-BA-5558-01A-01D-1512-08		7386198	73809012	150	3074											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	5	11	9	16	2	3	0	0	0	3	0	7	1	5	1	3	3	1	1	3	3	0	2	rs28934574		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	53					0	0	0	0	A	7577094	A	A	7577094	3	1	13	1	0	0	0	0	1	0	0	0	16448	1115	39	1	442	1	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	190896	7577094	73618116	151	3075											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	7	7	13	14	3	3	0	3	0	0	0	4	0	4	0	3	3	3	2	3	3	1	0	rs28934578		TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	71					0	0	0	0	T	7578406	T	T	7578406	3	4	13	1	0	0	0	0	1	0	0	0	16448	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	1312	7578406	73616804	152	3076											
ALOX12B	242	broad.mit.edu	37	chr17	7983140	7983140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggaacggagccaccatgtCgtctgtgacggggaacttgt	9	8	14	10	3	1	1	0	1	1	0	2	4	1	4	2	4	3	0	2	4	2	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:7983140C>T	uc002gjy.1	-	7	1135	c.874G>A	c.(874-876)GAC>AAC	p.D292N	uc010cnq.1_RNA	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	292	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						GCCACCATGTCGTCTGTGACG	0.572										Multiple Myeloma(8;0.094)			13	35					0	0	0	0	T	7983140	T	T	7983140	3	4	13	1	0	0	0	0	1	0	0	0	537	884	31	1	1267	1	ALOX12B	17	7983140	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	404734	7983140	73212070	153	3077											
ALOX12B	242	broad.mit.edu	37	chr17	7983186	7983186	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccgcgtgcagcggcggatCaggccggggttgacgccgtt	5	7	17	12	7	1	1	1	1	0	0	2	2	2	2	3	5	2	3	3	5	0	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:7983186C>G	uc002gjy.1	-	7	1089	c.828G>C	c.(826-828)CTG>CTC	p.L276L	uc010cnq.1_RNA	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	276	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						AGCGGCGGATCAGGCCGGGGT	0.652										Multiple Myeloma(8;0.094)			7	35					0	0	0	0	G	7983186	G	G	7983186	2	3	13	1	0	0	0	0	0	0	0	1	537	813	29	2		2	ALOX12B	17	7983186	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	46	7983186	73212024	154	3078											
DNAH9	1770	broad.mit.edu	37	chr17	11738200	11738200	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagcagcgcaggcagctctCaacaccctgaacaaggtagg	13	4	11	13	1	1	1	1	1	1	0	2	1	1	1	1	3	5	5	1	3	4	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:11738200C>G	uc002gne.2	+	49	9560	c.9492C>G	c.(9490-9492)CTC>CTG	p.L3164L	DNAH9_uc010coo.2_Silent_p.L2458L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3164	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGGCAGCTCTCAACACCCTGA	0.572													4	31					0	0	0	0	G	11738200	G	G	11738200	2	3	13	1	0	0	0	0	0	0	0	1	4630	813	29	2		2	DNAH9	17	11738200	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	3755014	11738200	69457010	155	3079											
CCDC55	84081	broad.mit.edu	37	chr17	28512309	28512309	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaaagatatgaaaataatGataaatacagagatagagaa	24	7	9	1	0	0	5	0	2	0	3	0	8	0	6	0	1	1	0	0	1	10	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:28512309G>A	uc002heu.2	+	7	1322	c.1294G>A	c.(1294-1296)GAT>AAT	p.D432N	CCDC55_uc002hev.2_Missense_Mutation_p.D378N|CCDC55_uc010wbl.1_Missense_Mutation_p.D378N|CCDC55_uc010wbm.1_Missense_Mutation_p.D378N|CCDC55_uc002hex.2_Missense_Mutation_p.D378N	NM_032141	NP_115517	Q9H0G5	NSRP1_HUMAN	coiled-coil domain containing 55 isoform 1	432					developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding				0						tgaaaataatgataaatacag	0.164													10	34					0	0	0	0	A	28512309	A	A	28512309	3	1	13	1	0	0	0	0	1	0	0	0	2838	1290	45	2	1320	2	CCDC55	17	28512309	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	16774109	28512309	52682901	156	3080											
NAGLU	4669	broad.mit.edu	37	chr17	40689478	40689478	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtgtggtgggactgggcccGctgggagcgagagatagact	7	7	19	8	3	0	2	0	0	0	2	0	6	0	4	1	4	1	1	1	4	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:40689478G>A	uc002hzv.2	+	2	786	c.446G>A	c.(445-447)CGC>CAC	p.R149H		NM_000263	NP_000254	P54802	ANAG_HUMAN	alpha-N-acetylglucosaminidase precursor	149						lysosome	alpha-N-acetylglucosaminidase activity				0		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	GACTGGGCCCGCTGGGAGCGA	0.627													4	133					0	0	0	0	A	40689478	A	A	40689478	3	1	13	1	0	0	0	0	1	0	0	0	10196	1087	38	1	452	1	NAGLU	17	40689478	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	12177169	40689478	40505732	157	3081											
C17orf57	124989	broad.mit.edu	37	chr17	45422422	45422422	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctctacatgacattatatGatgaagtaacccatggatat	15	12	6	8	0	1	3	0	3	1	0	1	4	1	4	2	1	2	1	2	1	6	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:45422422G>A	uc002iln.2	+	8	886	c.475G>A	c.(475-477)GAT>AAT	p.D159N	C17orf57_uc002ilm.2_Missense_Mutation_p.D159N|C17orf57_uc002ill.1_Missense_Mutation_p.D11N|C17orf57_uc010daz.1_Missense_Mutation_p.D159N	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	159							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						GACATTATATGATGAAGTAAC	0.313													48	175					0	0	0	0	A	45422422	A	A	45422422	3	1	13	1	0	0	0	0	1	0	0	0	1872	1290	45	2	493	2	C17orf57	17	45422422	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	4732944	45422422	35772788	158	3082											
COX11	1353	broad.mit.edu	37	chr17	53040725	53040725	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caatattgtatgtagaaattCcaattactggtttgtcagta	13	16	7	5	0	1	1	1	0	0	1	2	1	2	1	1	1	1	4	1	1	8	8			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:53040725C>G	uc010wng.1	-	3	647	c.590G>C	c.(589-591)GGA>GCA	p.G197A	COX11_uc010wne.1_RNA|COX11_uc010wnf.1_RNA|COX11_uc002iue.2_RNA|COX11_uc010wnh.1_Missense_Mutation_p.G197A	NM_004375	NP_004366	Q9Y6N1	COX11_HUMAN	COX11 homolog, cytochrome c oxidase assembly	197	Mitochondrial intermembrane (Potential).|Mitochondrial matrix (Potential).				respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	copper ion binding|cytochrome-c oxidase activity|electron carrier activity			ovary(1)	1						TGTAGAAATTCCAATTACTGG	0.323													26	94					0	0	0	0	G	53040725	G	G	53040725	3	3	13	1	0	0	0	0	1	0	0	0	3778	855	30	2	314	2	COX11	17	53040725	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	7618303	53040725	28154485	159	3083											
KCNJ2	3759	broad.mit.edu	37	chr17	68171901	68171901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccagaattacttctgaagggGagtatatccctctggatcaa	12	11	9	9	0	3	2	1	1	2	1	4	4	4	4	2	3	1	1	2	3	6	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:68171901G>A	uc010dfg.2	+	2	1122	c.721G>A	c.(721-723)GAG>AAG	p.E241K	KCNJ2_uc002jir.2_Missense_Mutation_p.E241K	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	241	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					TTCTGAAGGGGAGTATATCCC	0.448													33	87					0	0	0	0	A	68171901	A	A	68171901	3	1	13	1	0	0	0	0	1	0	0	0	8090	1175	41	2	723	2	KCNJ2	17	68171901	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	15131176	68171901	13023309	160	3084											
EXOC7	23265	broad.mit.edu	37	chr17	74085376	74085376	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtggatgtaggcatcggtCtccacgtccagcatgtcatc	8	10	11	12	2	2	0	1	0	1	0	6	1	3	1	2	3	1	3	2	3	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:74085376C>T	uc002jqs.2	-	9	1175	c.1080G>A	c.(1078-1080)GAG>GAA	p.E360E	EXOC7_uc010dgv.1_Silent_p.E256E|EXOC7_uc002jqq.2_Silent_p.E309E|EXOC7_uc010wsw.1_Silent_p.E332E|EXOC7_uc010wsx.1_Silent_p.E301E|EXOC7_uc002jqr.2_Silent_p.E278E|EXOC7_uc010wsv.1_Silent_p.E268E	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	360					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			AGGCATCGGTCTCCACGTCCA	0.637													18	45					0	0	0	0	T	74085376	T	T	74085376	2	4	13	1	0	0	0	0	0	0	0	1	5334	912	32	2		2	EXOC7	17	74085376	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	5913475	74085376	7109834	161	3085											
RPTOR	57521	broad.mit.edu	37	chr17	78681774	78681774	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtgccccggcccacagtcaAcggggaggtctgggtcttca	6	7	15	13	2	4	0	2	0	2	0	4	1	4	1	3	6	2	0	3	6	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr17:78681774A>G	uc002jyt.1	+	4	1287	c.482A>G	c.(481-483)AAC>AGC	p.N161S	RPTOR_uc002jys.2_Missense_Mutation_p.N161S|RPTOR_uc010wuf.1_5'UTR|RPTOR_uc010wug.1_Missense_Mutation_p.N161S	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	161					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CCCACAGTCAACGGGGAGGTC	0.592													11	28					0	0	0	0	G	78681774	G	G	78681774	3	3	13	1	0	0	0	0	1	0	0	0	13730	43	2	5	496	5	RPTOR	17	78681774	Missense_Mutation	SNP	A	TCGA-BA-5558-01A-01D-1512-08	4596398	78681774	2513436	162	3086											
FAM59A	64762	broad.mit.edu	37	chr18	29867529	29867529	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtcggttttcacatcaCggacagcccgtgaatactca	10	10	8	13	3	3	1	3	1	0	0	5	2	4	2	2	2	2	1	2	2	2	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr18:29867529C>A	uc002kxl.2	-	4	1087	c.1031G>T	c.(1030-1032)CGT>CTT	p.R344L	FAM59A_uc002kxk.1_Missense_Mutation_p.R344L	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	344										ovary(1)|skin(1)	2						TTTCACATCACGGACAGCCCG	0.562													33	67					4.34311e-12	4.77949e-12	1	0	A	29867529	A	A	29867529	3	1	13	1	0	0	0	0	1	0	0	0	5624	536	19	3	1608	3	FAM59A	18	29867529	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08		29867529	48209719	163	3087											
MYO5B	4645	broad.mit.edu	37	chr18	47563335	47563335	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatagattggcaactgttCataaggattaatggcaacaa	15	11	8	7	0	1	1	1	0	0	1	2	2	2	2	1	3	2	3	1	3	6	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr18:47563335C>T	uc002leb.2	-	4	628	c.340G>A	c.(340-342)GAA>AAA	p.E114K	MYO5B_uc002lec.1_Missense_Mutation_p.E113K	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	114	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GGCAACTGTTCATAAGGATTA	0.468													17	40					0	0	0	0	T	47563335	T	T	47563335	3	4	13	1	0	0	0	0	1	0	0	0	10132	835	29	2	5354	2	MYO5B	18	47563335	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	17695806	47563335	30513913	164	3088											
POLRMT	5442	broad.mit.edu	37	chr19	618526	618526	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgagcatcatgtgggaggaGtccagcgagtggatgaagtt	10	9	17	5	1	1	2	1	2	0	0	2	6	2	5	1	3	2	2	1	3	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:618526G>T	uc002lpf.1	-	17	3440	c.3384C>A	c.(3382-3384)GAC>GAA	p.D1128E		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	1128	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGGGAGGAGTCCAGCGAGT	0.662													11	30					6.40141e-05	6.72294e-05	1	0	T	618526	T	T	618526	3	4	13	1	0	0	0	0	1	0	0	0	12293	1020	36	4	328	4	POLRMT	19	618526	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08		618526	58510457	165	3089											
TUBB4	10382	broad.mit.edu	37	chr19	6501305	6501305	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgggggactcaccaaacacGaagttgtccggccgaaagat	12	6	12	11	3	1	1	1	0	0	1	2	4	2	2	3	3	1	1	3	3	3	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:6501305G>C	uc002mfg.1	-	3	377	c.270C>G	c.(268-270)TTC>TTG	p.F90L	TUBB4_uc002mff.1_Missense_Mutation_p.F18L	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	90					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		CACCAAACACGAAGTTGTCCG	0.592													11	57					0	0	0	0	C	6501305	C	C	6501305	3	2	13	1	0	0	0	0	1	0	0	0	16826	1049	37	3	1072	3	TUBB4	19	6501305	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	5882779	6501305	52627678	166	3090											
MUC16	94025	broad.mit.edu	37	chr19	9056712	9056712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taaacctggattctgggaagGaggttatcccagtggactcc	10	10	12	9	0	1	0	0	0	1	0	3	4	3	4	3	5	1	1	3	5	4	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:9056712G>A	uc002mkp.2	-	3	30938	c.30734C>T	c.(30733-30735)TCC>TTC	p.S10245F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10247	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCTGGGAAGGAGGTTATCCC	0.463													24	62					0	0	0	0	A	9056712	A	A	9056712	3	1	13	1	0	0	0	0	1	0	0	0	10026	1174	41	2	13117	2	MUC16	19	9056712	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	2555407	9056712	50072271	167	3091											
CCDC151	115948	broad.mit.edu	37	chr19	11545748	11545748	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgggtttgcccgaagcctcCctgcccttgaccctggaaga	6	9	11	15	1	0	2	0	1	0	1	1	4	1	3	5	2	3	1	5	2	2	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:11545748C>T	uc002mrs.2	-	1	233	c.90G>A	c.(88-90)AGG>AGA	p.R30R	CCDC151_uc010dxz.2_Silent_p.R30R|PRKCSH_uc002mrt.2_5'Flank|PRKCSH_uc002mru.2_5'Flank|PRKCSH_uc010xlz.1_5'Flank|PRKCSH_uc010dya.2_5'Flank|PRKCSH_uc002mrv.1_5'Flank|PRKCSH_uc010dyb.2_5'Flank	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	30										ovary(1)	1						CCGAAGCCTCCCTGCCCTTGA	0.667											OREG0025257	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	97					0	0	0	0	T	11545748	T	T	11545748	2	4	13	1	0	0	0	0	0	0	0	1	2798	622	22	4		4	CCDC151	19	11545748	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	2489036	11545748	47583235	168	3092											
SFRS16	11129	broad.mit.edu	37	chr19	45561076	45561076	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggccaaggtagagaaggCggcagaaaagccagaggagg	14	2	19	6	1	0	3	0	0	0	3	0	5	0	4	2	7	1	2	2	7	5	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:45561076C>T	uc002pak.2	+	7	631	c.533C>T	c.(532-534)GCG>GTG	p.A178V	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Missense_Mutation_p.A116V|SFRS16_uc002pam.2_Missense_Mutation_p.A178V|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	178					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GTAGAGAAGGCGGCAGAAAAG	0.612													27	131					0	0	0	0	T	45561076	T	T	45561076	3	4	13	1	0	0	0	0	1	0	0	0	14237	768	27	1	555	1	SFRS16	19	45561076	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	34015328	45561076	13567907	169	3093											
SLC8A2	6543	broad.mit.edu	37	chr19	47935484	47935484	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacagagtccttgaggccaaCggtgcagccgaagtgggagg	10	5	17	9	2	0	2	0	1	0	1	1	5	1	3	3	4	3	1	3	4	2	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:47935484C>T	uc002pgx.2	-	9	2607	c.2329G>A	c.(2329-2331)GTT>ATT	p.V777I	SLC8A2_uc010xyq.1_Missense_Mutation_p.V533I|SLC8A2_uc010xyr.1_Missense_Mutation_p.V240I|SLC8A2_uc010ele.2_Missense_Mutation_p.V777I	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	777	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		TTGAGGCCAACGGTGCAGCCG	0.607													14	89					0	0	0	0	T	47935484	T	T	47935484	3	4	13	1	0	0	0	0	1	0	0	0	14771	536	19	1	444	1	SLC8A2	19	47935484	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	2374408	47935484	11193499	170	3094											
CCDC114	93233	broad.mit.edu	37	chr19	48801464	48801464	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggaaggcctgcactgtcagGagctccaccagccgcttctc	8	7	11	15	1	2	0	1	0	1	0	4	2	3	2	4	3	3	3	4	3	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:48801464G>T	uc002pir.2	-	11	1946	c.1263C>A	c.(1261-1263)CTC>CTA	p.L421L	CCDC114_uc002piq.2_Silent_p.L230L|CCDC114_uc002pio.2_Silent_p.L458L|CCDC114_uc002pis.1_Silent_p.L101L|CCDC114_uc002pit.1_Silent_p.L458L	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	421										ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		GCACTGTCAGGAGCTCCACCA	0.652													13	63					5.50884e-06	5.81208e-06	1	0	T	48801464	T	T	48801464	2	4	13	1	0	0	0	0	0	0	0	1	2763	1161	41	2		2	CCDC114	19	48801464	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	865980	48801464	10327519	171	3095											
HAS1	3036	broad.mit.edu	37	chr19	52216936	52216936	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtagttagcggccagcttcCgccggcccgaggtgccccag	5	6	14	16	5	0	0	0	0	0	0	1	1	1	0	6	3	3	3	6	3	2	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:52216936C>T	uc002pxo.1	-	5	1516	c.1481G>A	c.(1480-1482)CGG>CAG	p.R494Q	HAS1_uc010epc.1_Missense_Mutation_p.R94Q|HAS1_uc010epd.1_3'UTR|HAS1_uc002pxn.1_Missense_Mutation_p.R501Q|HAS1_uc002pxp.1_Missense_Mutation_p.R493Q	NM_001523	NP_001514	Q92839	HAS1_HUMAN	hyaluronan synthase 1	494	Extracellular (Potential).				cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			ovary(1)|pancreas(1)	2		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GGCCAGCTTCCGCCGGCCCGA	0.687													5	4					0	0	0	0	T	52216936	T	T	52216936	3	4	13	1	0	0	0	0	1	0	0	0	7000	652	23	1	259	1	HAS1	19	52216936	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	3415472	52216936	6912047	172	3096											
PPP2R1A	5518	broad.mit.edu	37	chr19	52709301	52709301	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggtgggaggcccagagtaCgtgcactgcctgctggtgag	6	8	17	10	1	0	2	0	1	0	1	0	3	0	3	2	4	4	3	2	4	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:52709301C>T	uc002pyp.2	+	3	414	c.255C>T	c.(253-255)TAC>TAT	p.Y85Y	PPP2R1A_uc010ydk.1_Intron|PPP2R1A_uc010epm.1_Silent_p.Y125Y|PPP2R1A_uc002pyq.2_Translation_Start_Site	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	85	PP2A subunit B binding.|SV40 small T antigen binding.|HEAT 3.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GCCCAGAGTACGTGCACTGCC	0.612			Mis		clear cell ovarian carcinoma								26	118					0	0	0	0	T	52709301	T	T	52709301	2	4	13	1	0	0	0	0	0	0	0	1	12442	547	19	1		1	PPP2R1A	19	52709301	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	492365	52709301	6419682	173	3097											
ZNF160	90338	broad.mit.edu	37	chr19	53578367	53578367	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccctgtataagatcctctGagcagggtccaggcatttcc	8	11	10	12	0	1	2	0	1	1	1	5	2	5	2	4	2	1	3	4	2	2	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:53578367G>C	uc010eqk.2	-	5	501	c.85C>G	c.(85-87)CAG>GAG	p.Q29E	ZNF160_uc002qaq.3_Missense_Mutation_p.Q29E|ZNF160_uc002qar.3_Missense_Mutation_p.Q29E|ZNF160_uc002qas.3_Missense_Mutation_p.Q29E	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	29	KRAB.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		AAGATCCTCTGAGCAGGGTCC	0.453													68	134					0	0	0	0	C	53578367	C	C	53578367	3	2	13	1	0	0	0	0	1	0	0	0	17806	1299	45	2	2383	2	ZNF160	19	53578367	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	869066	53578367	5550616	174	3098											
FCAR	2204	broad.mit.edu	37	chr19	55401040	55401040	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atccaccaagattacacgacGcagaacttgatccgcatggc	13	7	8	13	3	0	3	0	1	0	2	2	4	2	3	3	1	2	2	3	1	3	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:55401040G>A	uc002qhr.1	+	5	872	c.675G>A	c.(673-675)ACG>ACA	p.T225T	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Silent_p.T176T|FCAR_uc010esi.1_Silent_p.T102T|FCAR_uc002qhu.1_Silent_p.T129T|FCAR_uc002qhv.1_Silent_p.T203T|FCAR_uc002qhw.1_Silent_p.T213T|FCAR_uc002qhx.1_Silent_p.T117T|FCAR_uc002qhy.1_Silent_p.T191T|FCAR_uc002qhz.1_Missense_Mutation_p.A189T|FCAR_uc002qia.1_Silent_p.T116T	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	225	Extracellular (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		ATTACACGACGCAGAACTTGA	0.527													123	537					0	0	0	0	A	55401040	A	A	55401040	2	1	13	1	0	0	0	0	0	0	0	1	5805	1087	38	1		1	FCAR	19	55401040	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	1822673	55401040	3727943	175	3099											
TMEM150B	284417	broad.mit.edu	37	chr19	55824413	55824413	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctacgcagcgagcaggcgtgGaggacgatcactgccccagg	9	4	15	13	4	1	0	1	0	0	0	1	4	1	2	2	4	4	2	2	4	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:55824413G>A	uc010esw.1	-	8	689	c.516C>T	c.(514-516)CTC>CTT	p.L172L	TMEM150B_uc010yfu.1_Silent_p.L172L|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	172	Helical; (Potential).					integral to membrane					0						AGCAGGCGTGGAGGACGATCA	0.687													5	15					0	0	0	0	A	55824413	A	A	55824413	2	1	13	1	0	0	0	0	0	0	0	1	16134	1161	41	2		2	TMEM150B	19	55824413	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08	423373	55824413	3304570	176	3100											
ZIM3	114026	broad.mit.edu	37	chr19	57646830	57646830	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttatgttgaatgagggttGagttctgcctgaaggatttc	8	17	12	4	0	1	4	0	4	1	0	2	5	1	5	1	2	1	3	1	2	3	6			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:57646830G>C	uc002qnz.1	-	5	1261	c.875C>G	c.(874-876)TCA>TGA	p.S292*		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	292	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AATGAGGGTTGAGTTCTGCCT	0.378													118	195					0	0	0	0	C	57646830	C	C	57646830	4	2	13	1	0	0	0	0	0	1	0	0	17752	1294	45	2	547	2	ZIM3	19	57646830	Nonsense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	1822417	57646830	1482153	177	3101											
VN1R1	57191	broad.mit.edu	37	chr19	57966870	57966870	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaactgagagatatgagtatCactcatgatgaggacaaaag	17	8	11	5	0	2	5	2	4	0	1	2	8	2	6	0	1	1	1	0	1	5	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr19:57966870C>T	uc002qos.1	-	1	985	c.985G>A	c.(985-987)GAT>AAT	p.D329N	ZNF547_uc002qpm.3_Intron	NM_020633	NP_065684	Q9GZP7	VN1R1_HUMAN	vomeronasal 1 receptor 1	329	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)|Breast(46;0.222)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)|Lung(386;0.171)		ATATGAGTATCACTCATGATG	0.463													30	99					0	0	0	0	T	57966870	T	T	57966870	3	4	13	1	0	0	0	0	1	0	0	0	17246	826	29	2	80	2	VN1R1	19	57966870	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	320040	57966870	1162113	178	3102											
SIRPG	55423	broad.mit.edu	37	chr20	1629897	1629897	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggccttctttttgattgtaGattaattcccggcctggtcc	5	17	9	10	1	1	2	0	1	1	1	3	2	3	2	4	3	0	1	4	3	2	7			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr20:1629897G>A	uc002wfm.1	-	2	296	c.231C>T	c.(229-231)ATC>ATT	p.I77I	SIRPG_uc002wfn.1_Silent_p.I77I|SIRPG_uc002wfo.1_Silent_p.I77I	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	77	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						TTTGATTGTAGATTAATTCCC	0.517													44	146					0	0	0	0	A	1629897	A	A	1629897	2	1	13	1	0	0	0	0	0	0	0	1	14401	932	33	2		2	SIRPG	20	1629897	Silent	SNP	G	TCGA-BA-5558-01A-01D-1512-08		1629897	61395623	179	3103											
EPB41L1	2036	broad.mit.edu	37	chr20	34806864	34806864	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcccacagacggtggccacgGaaatccgttctctttctccg	7	9	10	15	4	2	1	0	0	2	1	5	2	3	2	4	3	0	1	4	3	1	2			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr20:34806864G>A	uc002xfb.2	+	18	2506	c.2335G>A	c.(2335-2337)GAA>AAA	p.E779K	EPB41L1_uc002xeu.2_Missense_Mutation_p.E677K|EPB41L1_uc010zvo.1_Missense_Mutation_p.E751K|EPB41L1_uc002xev.2_Missense_Mutation_p.E778K|EPB41L1_uc002xew.2_Missense_Mutation_p.E670K|EPB41L1_uc002xex.2_Missense_Mutation_p.E599K|EPB41L1_uc002xey.2_Missense_Mutation_p.E529K|EPB41L1_uc002xez.2_Missense_Mutation_p.E677K|EPB41L1_uc010gfq.2_Missense_Mutation_p.E877K	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	779	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					GGTGGCCACGGAAATCCGTTC	0.582													10	38					0	0	0	0	A	34806864	A	A	34806864	3	1	13	1	0	0	0	0	1	0	0	0	5176	1175	41	2	2401	2	EPB41L1	20	34806864	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	33176967	34806864	28218656	180	3104											
PTPRT	11122	broad.mit.edu	37	chr20	40979290	40979290	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaggagctccccgggactGagcgggtttcagcatcactg	8	7	14	12	2	2	1	2	1	0	0	3	4	3	3	2	3	3	3	2	3	0	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr20:40979290G>A	uc002xkg.2	-	11	2027	c.1843C>T	c.(1843-1845)CAG>TAG	p.Q615*	PTPRT_uc010ggj.2_Nonsense_Mutation_p.Q615*	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	615	Extracellular (Potential).|Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCCCGGGACTGAGCGGGTTTC	0.527													30	139					0	0	0	0	A	40979290	A	A	40979290	4	1	13	1	0	0	0	0	0	1	0	0	12877	1299	45	2	2627	2	PTPRT	20	40979290	Nonsense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	6172426	40979290	22046230	181	3105											
C20orf111	51526	broad.mit.edu	37	chr20	42825779	42825779	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgacaggtcctcaatggtCacatcatccacgaagactcg	11	8	8	14	2	3	2	3	1	0	1	6	3	5	2	3	2	0	0	3	2	2	0			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr20:42825779C>T	uc002xlk.2	-	4	929	c.792G>A	c.(790-792)GTG>GTA	p.V264V		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	264											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CCTCAATGGTCACATCATCCA	0.488													30	159					0	0	0	0	T	42825779	T	T	42825779	2	4	13	1	0	0	0	0	0	0	0	1	2090	813	29	2		2	C20orf111	20	42825779	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	1846489	42825779	20199741	182	3106											
STAU1	6780	broad.mit.edu	37	chr20	47734390	47734390	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccatggggtacgtggcctGaagagatgttattctttaaa	10	13	12	6	1	1	2	0	1	1	1	2	3	2	2	2	3	1	2	2	3	5	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr20:47734390G>A	uc002xud.2	-	11	1844	c.1433C>T	c.(1432-1434)TCA>TTA	p.S478L	STAU1_uc002xua.2_Missense_Mutation_p.S397L|STAU1_uc002xub.2_Missense_Mutation_p.S403L|STAU1_uc002xuc.2_Missense_Mutation_p.S397L|STAU1_uc002xue.2_Missense_Mutation_p.S397L|STAU1_uc002xuf.2_Missense_Mutation_p.S403L|STAU1_uc002xug.2_Missense_Mutation_p.S478L	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	478						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TACGTGGCCTGAAGAGATGTT	0.537													24	93					0	0	0	0	A	47734390	A	A	47734390	3	1	13	1	0	0	0	0	1	0	0	0	15338	1294	45	2	316	2	STAU1	20	47734390	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08	4908611	47734390	15291130	183	3107											
PI4KA	5297	broad.mit.edu	37	chr22	21115663	21115663	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagcgatcaggatctgttGaacgcagtaccctaagaaga	14	7	12	8	2	2	3	1	1	1	2	2	6	2	5	1	2	3	3	1	2	5	3			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chr22:21115663G>A	uc002zsz.3	-	23	2777	c.2546C>T	c.(2545-2547)TCA>TTA	p.S849L		NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	849					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			AGGATCTGTTGAACGCAGTAC	0.393													23	46					0	0	0	0	A	21115663	A	A	21115663	3	1	13	1	0	0	0	0	1	0	0	0	11928	1294	45	2	3720	2	PI4KA	22	21115663	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08		21115663	30188903	184	3108											
MED14	9282	broad.mit.edu	37	chrX	40522377	40522377	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agagcgctgaggtagtttacGaggtggaggcatgtttgttg	8	12	17	4	2	0	2	0	1	0	1	0	4	0	3	0	4	2	6	0	4	2	5			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chrX:40522377G>A	uc004dex.3	-	26	3624	c.3484C>T	c.(3484-3486)CGT>TGT	p.R1162C	MED14_uc004dey.1_Missense_Mutation_p.R64C	NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	1162	Pro-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						GGTAGTTTACGAGGTGGAGGC	0.453													10	10					0	0	0	0	A	40522377	A	A	40522377	3	1	13	1	0	0	0	0	1	0	0	0	9485	1058	37	1	904	1	MED14	23	40522377	Missense_Mutation	SNP	G	TCGA-BA-5558-01A-01D-1512-08		40522377	114748183	185	3109											
GDPD2	54857	broad.mit.edu	37	chrX	69649354	69649354	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttatagaggcgacccttCtggggggccaaaccgctggc	7	9	13	12	2	2	1	0	0	2	1	2	2	2	1	3	5	1	1	3	5	3	4			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chrX:69649354C>T	uc004dyh.2	+	11	1199	c.948C>T	c.(946-948)TTC>TTT	p.F316F	GDPD2_uc010nkx.1_3'UTR|GDPD2_uc010nky.1_Silent_p.F102F|GDPD2_uc011mpk.1_Silent_p.F316F|GDPD2_uc011mpl.1_Silent_p.F237F|GDPD2_uc011mpm.1_Silent_p.F237F	NM_017711	NP_060181	Q9HCC8	GDPD2_HUMAN	osteoblast differentiation promoting factor	316	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			ovary(2)	2	Renal(35;0.156)					GGCGACCCTTCTGGGGGGCCA	0.522													12	16					0	0	0	0	T	69649354	T	T	69649354	2	4	13	1	0	0	0	0	0	0	0	1	6361	912	32	2		2	GDPD2	23	69649354	Silent	SNP	C	TCGA-BA-5558-01A-01D-1512-08	29126977	69649354	85621206	186	3110											
DRP2	1821	broad.mit.edu	37	chrX	100511136	100511136	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccagtacctgctgcggcactCcagccccatcacagaccggg	8	5	10	18	2	1	1	1	0	0	1	2	1	2	1	6	2	4	3	6	2	1	1			TCGA-BA-5558-01A-01D-1512-08	TCGA-BA-5558-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a47fa4-c857-4483-9572-07012c10e9d5	f7632fc3-3c2c-424e-84a7-51bea026ebf5	g.chrX:100511136C>G	uc004egz.2	+	21	2645	c.2276C>G	c.(2275-2277)TCC>TGC	p.S759C	DRP2_uc011mrh.1_Missense_Mutation_p.S681C	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	759					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						CTGCGGCACTCCAGCCCCATC	0.572													26	58					0	0	0	0	G	100511136	G	G	100511136	3	3	13	1	0	0	0	0	1	0	0	0	4786	855	30	2	2350	2	DRP2	23	100511136	Missense_Mutation	SNP	C	TCGA-BA-5558-01A-01D-1512-08	30861782	100511136	54759424	187	3111											
CDC20	991	broad.mit.edu	37	chr1	43825460	43825460	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaggaagccaagatccttcGgctcagtggaaaaccacaaa	16	5	10	10	1	1	2	1	0	0	2	3	4	2	4	3	3	2	1	3	3	5	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:43825460G>C	uc001cix.2	+	4	496	c.395G>C	c.(394-396)CGG>CCG	p.R132P	CDC20_uc001ciy.2_Missense_Mutation_p.R132P	NM_001255	NP_001246	Q12834	CDC20_HUMAN	cell division cycle 20	132				R->A: Loss of interaction with MAD2L1.	activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AAGATCCTTCGGCTCAGTGGA	0.502													102	164					0	0	0	0	C	43825460	C	C	43825460	3	2	14	1	0	0	0	0	1	0	0	0	3074	1116	39	3	405	3	CDC20	1	43825460	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		43825460	205425161	1	3112											
KIAA0467	23334	broad.mit.edu	37	chr1	43881682	43881682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgggccggaaggtaggcGtctccatggtgacagctgat	8	9	15	9	2	1	2	0	2	1	0	2	3	1	3	2	5	2	2	2	5	3	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:43881682G>A	uc009vws.1	+	6	766	c.682G>A	c.(682-684)GTC>ATC	p.V228I				Q5T011	SZT2_HUMAN	Homo sapiens mRNA for KIAA0467 protein, partial cds.	228						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GAAGGTAGGCGTCTCCATGGT	0.552													8	26					0	0	0	0	A	43881682	A	A	43881682	3	1	14	1	0	0	0	0	1	0	0	0	8217	1160	40	1		1	KIAA0467	1	43881682	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	56222	43881682	205368939	2	3113											
PTPRF	5792	broad.mit.edu	37	chr1	44044587	44044587	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccctgcgaacctgtatgtGcgaggtaaggactcaggcag	9	7	14	11	2	1	0	1	0	0	0	1	3	1	1	3	3	3	3	3	3	3	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:44044587G>A	uc001cjr.2	+	7	1015	c.675G>A	c.(673-675)GTG>GTA	p.V225V	PTPRF_uc001cjq.3_Silent_p.V231V|PTPRF_uc001cjs.2_Silent_p.V225V|PTPRF_uc001cjt.3_Silent_p.V225V	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	225	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACCTGTATGTGCGAGGTAAGG	0.612													3	39					0	0	0	0	A	44044587	A	A	44044587	2	1	14	1	0	0	0	0	0	0	0	1	12866	1306	46	4		4	PTPRF	1	44044587	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	162905	44044587	205206034	3	3114											
LPPR4	9890	broad.mit.edu	37	chr1	99771805	99771805	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccagcctggcgctgtccccGgatgtaacaacagcatgcct	8	8	10	15	2	0	0	0	0	0	0	2	1	2	1	5	2	5	3	5	2	2	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:99771805G>A	uc001dse.2	+	7	1637	c.1531G>A	c.(1531-1533)GGA>AGA	p.G511R	LPPR4_uc010oue.1_Missense_Mutation_p.G453R	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	511							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CGCTGTCCCCGGATGTAACAA	0.552													17	384					0	0	0	0	A	99771805	A	A	99771805	3	1	14	1	0	0	0	0	1	0	0	0	8977	1117	39	1	1557	1	LPPR4	1	99771805	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	55727218	99771805	149478816	4	3115											
AMIGO1	57463	broad.mit.edu	37	chr1	110051444	110051444	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggcaggacagctaaccaCggctcggccagctctggcca	8	4	14	15	3	1	0	0	0	1	0	2	1	1	1	3	6	3	4	3	6	1	1	rs139908524		TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:110051444C>T	uc001dxx.3	-	2	473	c.91G>A	c.(91-93)GTG>ATG	p.V31M		NM_020703	NP_065754	Q86WK6	AMGO1_HUMAN	AMIGO protein precursor	31	LRRNT.|Extracellular (Potential).				axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				ovary(1)|breast(1)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		CAGCTAACCACGGCTCGGCCA	0.627													11	29					0	0	0	0	T	110051444	T	T	110051444	3	4	14	1	0	0	0	0	1	0	0	0	575	536	19	1	1394	1	AMIGO1	1	110051444	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	10279639	110051444	139199177	5	3116											
ARHGEF11	9826	broad.mit.edu	37	chr1	156950259	156950259	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggtcgccctctttcacaccGgccttcatggctgcacctcc	4	10	8	19	3	3	0	2	0	1	0	5	0	4	0	5	3	1	2	5	3	0	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:156950259G>A	uc001fqo.2	-	4	1283	c.243C>T	c.(241-243)GCC>GCT	p.A81A	ARHGEF11_uc001fqn.2_Silent_p.A81A	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	81	PDZ.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTTTCACACCGGCCTTCATGG	0.567													5	11					0	0	0	0	A	156950259	A	A	156950259	2	1	14	1	0	0	0	0	0	0	0	1	896	1103	39	1		1	ARHGEF11	1	156950259	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	46898815	156950259	92300362	6	3117											
ATP1A2	477	broad.mit.edu	37	chr1	160104995	160104995	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacatgacatcggagcagctCgatgagatcctcaagaacca	14	6	10	11	2	1	3	1	2	0	2	4	7	2	4	2	1	3	2	2	1	2	0			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:160104995C>T	uc001fvc.2	+	15	2157	c.2025C>T	c.(2023-2025)CTC>CTT	p.L675L	ATP1A2_uc001fvb.2_Silent_p.L675L|ATP1A2_uc001fvd.2_Silent_p.L411L	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	675	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CGGAGCAGCTCGATGAGATCC	0.577													34	59					0	0	0	0	T	160104995	T	T	160104995	2	4	14	1	0	0	0	0	0	0	0	1	1131	871	31	1		1	ATP1A2	1	160104995	Silent	SNP	C	TCGA-BA-5559-01A-01D-1512-08	3154736	160104995	89145626	7	3118											
PAPPA2	60676	broad.mit.edu	37	chr1	176525894	176525894	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agctgctgggagatgatgacGcttatctcggcaatcaaaga	12	9	12	8	2	2	4	1	2	1	2	3	5	2	4	0	2	2	4	0	2	3	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:176525894G>A	uc001gkz.2	+	2	1600	c.436G>A	c.(436-438)GCT>ACT	p.A146T	PAPPA2_uc001gky.1_Missense_Mutation_p.A146T|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	146					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGATGATGACGCTTATCTCGG	0.542													6	209					0	0	0	0	A	176525894	A	A	176525894	3	1	14	1	0	0	0	0	1	0	0	0	11487	1087	38	1	438	1	PAPPA2	1	176525894	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	16420899	176525894	72724727	8	3119											
CACNA1E	777	broad.mit.edu	37	chr1	181745355	181745355	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtctgggcagaatatgaccGagcagcatggtgcgtaggcc	9	7	15	10	3	1	2	0	1	1	1	1	3	1	2	2	3	3	4	2	3	3	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:181745355G>A	uc001gow.2	+	38	5423	c.5258G>A	c.(5257-5259)CGA>CAA	p.R1753Q	CACNA1E_uc009wxs.2_Missense_Mutation_p.R1641Q|CACNA1E_uc001gox.1_Missense_Mutation_p.R979Q|CACNA1E_uc009wxt.2_Missense_Mutation_p.R979Q	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1753	EF-hand.|By similarity.|Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GAATATGACCGAGCAGCATGG	0.612													6	168					0	0	0	0	A	181745355	A	A	181745355	3	1	14	1	0	0	0	0	1	0	0	0	2554	1058	37	1	5408	1	CACNA1E	1	181745355	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	5219461	181745355	67505266	9	3120											
CACNA1S	779	broad.mit.edu	37	chr1	201046135	201046135	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtcatacctccccccaaaGagctgcatgcccaggagggc	11	5	10	15	0	1	1	1	0	0	1	2	2	2	2	5	2	4	2	5	2	3	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:201046135G>C	uc001gvv.2	-	12	1967	c.1740C>G	c.(1738-1740)CTC>CTG	p.L580L		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	580	II.|Helical; Name=S5 of repeat II; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCCCCCCAAAGAGCTGCATGC	0.473													16	145					0	0	0	0	C	201046135	C	C	201046135	2	2	14	1	0	0	0	0	0	0	0	1	2559	929	33	2		2	CACNA1S	1	201046135	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	19300780	201046135	48204486	10	3121											
CHI3L1	1116	broad.mit.edu	37	chr1	203150383	203150383	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgccaggctccatgaaaatcGtaggtcatgatgctaatgaa	13	9	10	9	2	1	3	1	3	0	0	3	3	2	3	2	2	1	3	2	2	5	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:203150383G>A	uc001gzi.2	-	7	789	c.618C>T	c.(616-618)TAC>TAT	p.Y206Y	FMOD_uc010pqi.1_Intron|CHI3L1_uc001gzk.1_Silent_p.Y3Y|CHI3L1_uc001gzj.2_Silent_p.Y206Y|CHI3L1_uc001gzl.3_5'Flank	NM_001276	NP_001267	P36222	CH3L1_HUMAN	chitinase 3-like 1 precursor	206	Chitooligosaccharide.				chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			pancreas(1)	1						CATGAAAATCGTAGGTCATGA	0.458													25	61					0	0	0	0	A	203150383	A	A	203150383	2	1	14	1	0	0	0	0	0	0	0	1	3355	1140	40	1		1	CHI3L1	1	203150383	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	2104248	203150383	46100238	11	3122											
GREM2	64388	broad.mit.edu	37	chr1	240656560	240656560	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcagcggctgcgtcttgcaCcagtcactcttgaggtactt	6	11	11	13	3	3	1	1	1	2	0	3	1	3	1	1	2	4	4	1	2	1	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:240656560C>G	uc001hys.2	-	2	496	c.216G>C	c.(214-216)TGG>TGC	p.W72C		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	72					BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			GCGTCTTGCACCAGTCACTCT	0.632													12	44					0	0	0	0	G	240656560	G	G	240656560	3	3	14	1	0	0	0	0	1	0	0	0	6801	508	18	4	294	4	GREM2	1	240656560	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	37506177	240656560	8594061	12	3123											
RGS7	6000	broad.mit.edu	37	chr1	240966240	240966240	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaagctcctgataggcactGgatcttataaaacgtgggta	13	10	11	7	1	1	2	0	1	1	1	2	3	2	3	1	3	2	3	1	3	6	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr1:240966240G>A	uc001hyv.2	-	16	1653	c.1323C>T	c.(1321-1323)TCC>TCT	p.S441S	RGS7_uc010pyh.1_Silent_p.S415S|RGS7_uc010pyj.1_Silent_p.S357S|RGS7_uc001hyu.2_Silent_p.S441S|RGS7_uc009xgn.1_Silent_p.S388S|RGS7_uc001hyw.2_Silent_p.S441S|RGS7_uc001hyt.2_Silent_p.S273S	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	441	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GATAGGCACTGGATCTTATAA	0.348													19	189					0	0	0	0	A	240966240	A	A	240966240	2	1	14	1	0	0	0	0	0	0	0	1	13375	1335	47	4		4	RGS7	1	240966240	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	309680	240966240	8284381	13	3124											
LRP1B	53353	broad.mit.edu	37	chr2	141806556	141806556	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtcacagtgtcacttaccAtctttcaggatggtttctct	8	16	7	10	0	5	0	3	0	2	0	6	1	5	1	1	2	1	1	1	2	1	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr2:141806556A>G	uc002tvj.1	-	11	2760	c.1788T>C	c.(1786-1788)GAT>GAC	p.D596D	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	596	Extracellular (Potential).|LDL-receptor class B 5.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTCACTTACCATCTTTCAGGA	0.418										TSP Lung(27;0.18)			45	148					0	0	0	0	G	141806556	G	G	141806556	2	3	14	1	0	0	0	0	0	0	0	1	9005	231	8	5		5	LRP1B	2	141806556	Silent	SNP	A	TCGA-BA-5559-01A-01D-1512-08		141806556	101392817	14	3125											
MBD5	55777	broad.mit.edu	37	chr2	149226535	149226535	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccacctccccctcctccAccttcttgtgctcttcagaa	5	11	5	20	0	3	1	1	0	2	1	6	1	6	1	7	1	1	1	7	1	1	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr2:149226535A>G	uc002twm.3	+	9	2011	c.1023A>G	c.(1021-1023)CCA>CCG	p.P341P	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Silent_p.P341P|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	341	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CCCCTCCTCCACCTTCTTGTG	0.428													13	58					0	0	0	0	G	149226535	G	G	149226535	2	3	14	1	0	0	0	0	0	0	0	1	9400	146	6	5		5	MBD5	2	149226535	Silent	SNP	A	TCGA-BA-5559-01A-01D-1512-08	7419979	149226535	93972838	15	3126											
ITGB6	3694	broad.mit.edu	37	chr2	161029176	161029176	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtttgctgtccattccaaaAtgagaatcagcatcactcac	13	11	6	11	0	3	1	3	1	0	1	5	2	5	1	2	0	2	3	2	0	3	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr2:161029176A>G	uc002ubh.2	-	6	841	c.825T>C	c.(823-825)CAT>CAC	p.H275H	ITGB6_uc010fow.1_RNA|ITGB6_uc010fou.2_Silent_p.H275H|ITGB6_uc010zcq.1_Silent_p.H233H|ITGB6_uc010fov.1_Silent_p.H275H	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	275	Extracellular (Potential).|VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						CCATTCCAAAATGAGAATCAG	0.448													10	213					0	0	0	0	G	161029176	G	G	161029176	2	3	14	1	0	0	0	0	0	0	0	1	7938	98	4	5		5	ITGB6	2	161029176	Silent	SNP	A	TCGA-BA-5559-01A-01D-1512-08	11802641	161029176	82170197	16	3127											
COL6A3	1293	broad.mit.edu	37	chr2	238269816	238269816	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agccgtcttctccaggaataCcctgaaacaaagtaatcggg	13	8	9	11	2	2	1	0	1	2	0	4	2	2	2	3	2	3	1	3	2	5	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr2:238269816C>A	uc002vwl.2	-	16	6443	c.6158G>T	c.(6157-6159)GGT>GTT	p.G2053V	COL6A3_uc002vwo.2_Missense_Mutation_p.G1847V|COL6A3_uc010znj.1_Missense_Mutation_p.G1446V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2053	Triple-helical region.|Collagen-like 1.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TCCAGGAATACCCTGAAACAA	0.478													4	72					2.56e-06	2.92923e-06	1	0	A	238269816	A	A	238269816	3	1	14	1	0	0	0	0	1	0	0	0	3716	521	18	4	3491	4	COL6A3	2	238269816	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	77240640	238269816	4929557	17	3128											
KLF15	28999	broad.mit.edu	37	chr3	126070938	126070938	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggcaatgcgcacaaacttGgagggcaggttcaagttgga	11	7	16	7	1	1	0	1	0	0	0	1	2	1	2	0	6	2	5	0	6	3	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr3:126070938G>C	uc011bkk.1	-	2	1010	c.828C>G	c.(826-828)TCC>TCG	p.S276S		NM_014079	NP_054798	Q9UIH9	KLF15_HUMAN	Kruppel-like factor 15	276						nucleus	DNA binding|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(114;0.147)		GCACAAACTTGGAGGGCAGGT	0.627													2	9					0	0	0	0	C	126070938	C	C	126070938	2	2	14	1	0	0	0	0	0	0	0	1	8382	1335	47	4		4	KLF15	3	126070938	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08		126070938	71951492	18	3129											
DNAJC13	23317	broad.mit.edu	37	chr3	132186135	132186135	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgatgcactggagggataGgatgggcattgctcaaaaag	13	9	14	5	0	1	1	1	1	0	0	1	4	1	4	0	4	2	3	0	4	3	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr3:132186135G>T	uc003eor.2	+	20	2251	c.2186G>T	c.(2185-2187)AGG>ATG	p.R729M	DNAJC13_uc010htq.1_Missense_Mutation_p.R729M	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	729							heat shock protein binding			ovary(1)|breast(1)	2						TGGAGGGATAGGATGGGCATT	0.398													12	154					6.40141e-05	7.18649e-05	1	0	T	132186135	T	T	132186135	3	4	14	1	0	0	0	0	1	0	0	0	4654	1000	35	4	2260	4	DNAJC13	3	132186135	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	6115197	132186135	65836295	19	3130											
FXR1	8087	broad.mit.edu	37	chr3	180688116	180688116	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggatggaatgactgaatctGatacagcttcagttaatgaa	14	12	10	5	0	2	4	1	4	1	0	2	6	2	6	0	2	2	2	0	2	5	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr3:180688116G>A	uc003fkq.2	+	15	1595	c.1573G>A	c.(1573-1575)GAT>AAT	p.D525N	FXR1_uc003fkp.2_Missense_Mutation_p.D440N|FXR1_uc003fkr.2_Missense_Mutation_p.D525N|FXR1_uc011bqj.1_Missense_Mutation_p.D439N|FXR1_uc003fks.2_Missense_Mutation_p.D468N|FXR1_uc011bqk.1_Missense_Mutation_p.D476N|FXR1_uc011bql.1_Missense_Mutation_p.D512N	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	525					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GACTGAATCTGATACAGCTTC	0.353													12	206					0	0	0	0	A	180688116	A	A	180688116	3	1	14	1	0	0	0	0	1	0	0	0	6149	1290	45	2	1631	2	FXR1	3	180688116	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	48501981	180688116	17334314	20	3131											
LYAR	55646	broad.mit.edu	37	chr4	4281210	4281210	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaaaagatattccacacctgGtccagaatggattcattatg	14	11	8	8	0	1	2	1	0	0	2	3	4	3	3	3	2	0	0	3	2	5	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr4:4281210G>C	uc011bvy.1	-	6	536	c.393C>G	c.(391-393)GAC>GAG	p.D131E	LYAR_uc011bvx.1_Missense_Mutation_p.D14E|LYAR_uc003ght.2_Missense_Mutation_p.D131E	NM_001145725	NP_001139197	Q9NX58	LYAR_HUMAN	Ly1 antibody reactive homolog	131						nucleolus	metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCCACACCTGGTCCAGAATGG	0.338													39	63					0	0	0	0	C	4281210	C	C	4281210	3	2	14	1	0	0	0	0	1	0	0	0	9154	1252	44	4	766	4	LYAR	4	4281210	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		4281210	186873066	21	3132											
CCKAR	886	broad.mit.edu	37	chr4	26491091	26491091	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagtacaagagaatctgcAccgctggctgccactctgca	11	7	11	12	1	2	1	0	0	2	1	2	3	2	2	2	2	4	5	2	2	3	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr4:26491091A>G	uc003gse.1	-	2	281	c.128T>C	c.(127-129)GTG>GCG	p.V43A		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	43	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	GAGAATCTGCACCGCTGGCTG	0.552													6	58					0	0	0	0	G	26491091	G	G	26491091	3	3	14	1	0	0	0	0	1	0	0	0	2893	159	6	5	1174	5	CCKAR	4	26491091	Missense_Mutation	SNP	A	TCGA-BA-5559-01A-01D-1512-08	22209881	26491091	164663185	22	3133											
UBA6	55236	broad.mit.edu	37	chr4	68490887	68490887	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctttttcaaatgaaagcActgccatctgaaggtcacct	12	12	6	11	0	4	2	2	2	2	0	4	2	4	2	2	1	2	1	2	1	3	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr4:68490887A>G	uc003hdg.3	-	29	2589	c.2537T>C	c.(2536-2538)GTG>GCG	p.V846A		NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	846					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						AAATGAAAGCACTGCCATCTG	0.368													4	150					0	0	0	0	G	68490887	G	G	68490887	3	3	14	1	0	0	0	0	1	0	0	0	16900	159	6	5	641	5	UBA6	4	68490887	Missense_Mutation	SNP	A	TCGA-BA-5559-01A-01D-1512-08	41999796	68490887	122663389	23	3134											
DNAH5	1767	broad.mit.edu	37	chr5	13701532	13701532	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagaaacccagtgtactaGaaatccaagaagcctgcaat	17	6	7	11	0	0	3	0	0	0	3	1	3	1	3	4	0	4	2	4	0	7	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:13701532G>C	uc003jfd.2	-	77	13394	c.13352C>G	c.(13351-13353)TCT>TGT	p.S4451C	DNAH5_uc003jfc.2_Missense_Mutation_p.S619C	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4451				S -> F (in Ref. 5; BAB15543).	microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CAGTGTACTAGAAATCCAAGA	0.373									Kartagener_syndrome				5	143					0	0	0	0	C	13701532	C	C	13701532	3	2	14	1	0	0	0	0	1	0	0	0	4626	942	33	2	534	2	DNAH5	5	13701532	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		13701532	167213728	24	3135											
PARP8	79668	broad.mit.edu	37	chr5	50091099	50091099	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattatatggactgaaaaatCacaaattgctcagcaagtcc	17	10	6	8	0	2	1	2	1	0	0	3	2	3	2	1	1	2	2	1	1	7	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:50091099C>T	uc003jon.3	+	13	1458	c.1276C>T	c.(1276-1278)CAC>TAC	p.H426Y	PARP8_uc011cpz.1_Missense_Mutation_p.H318Y|PARP8_uc003joo.2_Missense_Mutation_p.H426Y|PARP8_uc003jop.2_Missense_Mutation_p.H426Y	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	426						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				ACTGAAAAATCACAAATTGCT	0.448													24	177					0	0	0	0	T	50091099	T	T	50091099	3	4	14	1	0	0	0	0	1	0	0	0	11519	826	29	2	1322	2	PARP8	5	50091099	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	36389567	50091099	130824161	25	3136											
FAM169A	26049	broad.mit.edu	37	chr5	74091962	74091962	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctctctgttcaggttcttCttccaggaattcttctgagc	5	16	7	13	0	6	1	1	1	5	0	8	2	7	2	2	2	1	2	2	2	1	6			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:74091962C>T	uc003kdm.2	-	11	1196	c.1153G>A	c.(1153-1155)GAA>AAA	p.E385K	FAM169A_uc010izm.2_Missense_Mutation_p.E325K|FAM169A_uc003kdl.2_Missense_Mutation_p.E203K	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	385	Asp/Glu-rich.										0						TCAGGTTCTTCTTCCAGGAAT	0.423													13	207					0	0	0	0	T	74091962	T	T	74091962	3	4	14	1	0	0	0	0	1	0	0	0	5515	922	32	2	871	2	FAM169A	5	74091962	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	24000863	74091962	106823298	26	3137											
DIAPH1	1729	broad.mit.edu	37	chr5	140960400	140960400	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagcaggatccatggctctGaccagcagtaggattccttc	10	9	10	12	0	1	1	0	1	1	0	4	3	3	3	3	3	2	4	3	3	1	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:140960400G>C	uc003llb.3	-	8	876	c.735C>G	c.(733-735)GTC>GTG	p.V245V	DIAPH1_uc003llc.3_Silent_p.V236V	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	245	GBD/FH3.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATGGCTCTGACCAGCAGTA	0.463													8	116					0	0	0	0	C	140960400	C	C	140960400	2	2	14	1	0	0	0	0	0	0	0	1	4540	1277	45	2		2	DIAPH1	5	140960400	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	66868438	140960400	39954860	27	3138											
PCDH12	51294	broad.mit.edu	37	chr5	141336689	141336689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagtgaactctcagcaaacGcagggctattgtcattggag	11	9	11	10	1	2	1	2	1	1	0	3	2	2	2	1	2	3	3	1	2	3	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:141336689G>A	uc003llx.2	-	1	1939	c.728C>T	c.(727-729)GCG>GTG	p.A243V		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	243	Extracellular (Potential).|Cadherin 2.				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCAGCAAACGCAGGGCTATT	0.512													24	93					0	0	0	0	A	141336689	A	A	141336689	3	1	14	1	0	0	0	0	1	0	0	0	11564	1087	38	1	2842	1	PCDH12	5	141336689	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	376289	141336689	39578571	28	3139											
TTC1	7265	broad.mit.edu	37	chr5	159476610	159476610	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctagatgaagccctggaaGactataaatctatattagaa	17	10	8	6	0	1	4	0	1	1	3	1	5	1	5	1	1	2	1	1	1	10	6			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:159476610G>A	uc003lxu.2	+	6	681	c.631G>A	c.(631-633)GAC>AAC	p.D211N		NM_003314	NP_003305	Q99614	TTC1_HUMAN	tetratricopeptide repeat domain 1	211	TPR 3.				protein folding		unfolded protein binding			skin(1)	1	Renal(175;0.00196)	all_hematologic(541;0.00014)|Breast(839;0.0101)|all_neural(177;0.0281)|Medulloblastoma(196;0.0425)|Lung NSC(249;0.119)|all_lung(500;0.163)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	Epithelial(171;8.37e-05)|all cancers(165;0.000694)|OV - Ovarian serous cystadenocarcinoma(192;0.0402)		AGCCCTGGAAGACTATAAATC	0.333													5	52					0	0	0	0	A	159476610	A	A	159476610	3	1	14	1	0	0	0	0	1	0	0	0	16746	942	33	2	649	2	TTC1	5	159476610	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	18139921	159476610	21438650	29	3140											
ATP10B	23120	broad.mit.edu	37	chr5	160042962	160042962	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatctccggaagtcctcttCgcttacaacctatgggatgg	8	11	9	13	2	2	0	0	0	2	0	5	2	3	2	4	3	2	1	4	3	4	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:160042962C>T	uc003lym.1	-	17	3383	c.2536G>A	c.(2536-2538)GAA>AAA	p.E846K	ATP10B_uc010jit.1_Missense_Mutation_p.E163K|ATP10B_uc003lyn.2_Missense_Mutation_p.E404K	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	846	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAGTCCTCTTCGCTTACAACC	0.527													17	55					0	0	0	0	T	160042962	T	T	160042962	3	4	14	1	0	0	0	0	1	0	0	0	1119	893	31	1	1889	1	ATP10B	5	160042962	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	566352	160042962	20872298	30	3141											
C5orf25	375484	broad.mit.edu	37	chr5	175717758	175717759	+	Frame_Shift_Del	DEL	CT	-	-																															ccttagagaaagttccttggCtctctgtcatggaaacccca																										TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr5:175717758_175717759delCT	uc003mds.3	+	4	1581_1582	c.1174_1175delCT	c.(1174-1176)CTCfs	p.L392fs	C5orf25_uc003mdt.3_Intron|C5orf25_uc003mdr.3_Intron|C5orf25_uc011dfk.1_Frame_Shift_Del_p.L411fs			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	392											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		AGTTCCTTGGCTCTCTGTCATG	0.515													---	---	---								-	175717759	-	-	175717758	7	5	14	1	0	1	0	1	0	0	0	0	2298	812	28	0		0	C5orf25	5	175717758	Frame_Shift_Del	DEL	CT	TCGA-BA-5559-01A-01D-1512-08	15674796	175717758	5197502	31	3142											
ABCC10	89845	broad.mit.edu	37	chr6	43400422	43400422	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggcacccttgctggcccGtggggcctgtggagagctcc	3	8	16	14	1	0	1	0	0	0	1	1	2	1	1	4	5	2	4	4	5	0	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:43400422G>A	uc003ouy.1	+	3	919	c.704G>A	c.(703-705)CGT>CAT	p.R235H	ABCC10_uc003ouz.1_Missense_Mutation_p.R192H	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	235						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TTGCTGGCCCGTGGGGCCTGT	0.637													11	66					0	0	0	0	A	43400422	A	A	43400422	3	1	14	1	0	0	0	0	1	0	0	0	50	1145	40	1	577	1	ABCC10	6	43400422	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		43400422	127714645	32	3143											
RIMS1	22999	broad.mit.edu	37	chr6	73023290	73023290	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatgtcagtgatgtttccGccatttcccgaaccagcagt	8	12	10	11	2	1	2	1	2	0	0	3	3	3	2	4	0	2	2	4	0	1	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:73023290G>A	uc003pga.2	+	28	4122	c.4045G>A	c.(4045-4047)GCC>ACC	p.A1349T	RIMS1_uc011dyb.1_Missense_Mutation_p.A746T|RIMS1_uc003pgc.2_Missense_Mutation_p.A798T|RIMS1_uc010kaq.2_Missense_Mutation_p.A669T|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Intron|RIMS1_uc011dyd.1_Intron|RIMS1_uc003pgf.2_Missense_Mutation_p.A358T|RIMS1_uc003pgg.2_Intron|RIMS1_uc003pgi.2_Intron|RIMS1_uc003pgh.2_Intron|RIMS1_uc003pgd.2_Missense_Mutation_p.A415T|RIMS1_uc003pge.2_Missense_Mutation_p.A389T|RIMS1_uc011dye.1_Missense_Mutation_p.A155T|RIMS1_uc011dyf.1_Intron	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1349	Ser-rich.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TGATGTTTCCGCCATTTCCCG	0.448													11	36					0	0	0	0	A	73023290	A	A	73023290	3	1	14	1	0	0	0	0	1	0	0	0	13432	1087	38	1	4318	1	RIMS1	6	73023290	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	29622868	73023290	98091777	33	3144											
SYNE1	23345	broad.mit.edu	37	chr6	152451872	152451872	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctgctatgtggactgctGacagagggtccaggctgtga	8	10	14	9	0	0	3	0	2	0	1	1	4	1	4	2	3	3	3	2	3	2	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:152451872G>A	uc010kiw.2	-	145	26738	c.26136C>T	c.(26134-26136)GTC>GTT	p.V8712V	SYNE1_uc010kiv.2_Silent_p.V3236V|SYNE1_uc003qos.3_Silent_p.V3236V|SYNE1_uc003qot.3_Silent_p.V8664V|SYNE1_uc003qou.3_Silent_p.V8712V|SYNE1_uc003qop.3_Silent_p.V897V|SYNE1_uc011eez.1_Intron|SYNE1_uc003qoq.3_Intron|SYNE1_uc003qor.3_Intron	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8712	Ser-rich.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTGGACTGCTGACAGAGGGTC	0.468										HNSCC(10;0.0054)			8	34					0	0	0	0	A	152451872	A	A	152451872	2	1	14	1	0	0	0	0	0	0	0	1	15511	1277	45	2		2	SYNE1	6	152451872	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	79428582	152451872	18663195	34	3145											
SYNE1	23345	broad.mit.edu	37	chr6	152728244	152728244	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagttgtttgaccatccctCaatctcatctctagttgaca	9	14	6	12	0	3	2	2	2	2	0	6	2	4	2	2	0	0	4	2	0	2	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:152728244C>G	uc010kiw.2	-	45	7230	c.6628G>C	c.(6628-6630)GAG>CAG	p.E2210Q	SYNE1_uc003qot.3_Missense_Mutation_p.E2217Q|SYNE1_uc003qou.3_Missense_Mutation_p.E2210Q|SYNE1_uc010kjb.1_Missense_Mutation_p.E2193Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2210	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACCATCCCTCAATCTCATCT	0.428										HNSCC(10;0.0054)			8	127					0	0	0	0	G	152728244	G	G	152728244	3	3	14	1	0	0	0	0	1	0	0	0	15511	835	29	2	20246	2	SYNE1	6	152728244	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	276372	152728244	18386823	35	3146											
SYNE1	23345	broad.mit.edu	37	chr6	152746543	152746543	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taatgatctgtggtaaatctCtccatctctcatccaactgc	10	14	5	12	0	4	1	1	1	3	0	8	1	6	1	2	1	2	1	2	1	4	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:152746543C>G	uc010kiw.2	-	39	5842	c.5240G>C	c.(5239-5241)AGA>ACA	p.R1747T	SYNE1_uc003qot.3_Missense_Mutation_p.R1754T|SYNE1_uc003qou.3_Missense_Mutation_p.R1747T|SYNE1_uc010kjb.1_Missense_Mutation_p.R1730T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1747	Spectrin 2.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGTAAATCTCTCCATCTCTC	0.318										HNSCC(10;0.0054)			5	163					0	0	0	0	G	152746543	G	G	152746543	3	3	14	1	0	0	0	0	1	0	0	0	15511	913	32	2	21658	2	SYNE1	6	152746543	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	18299	152746543	18368524	36	3147											
C6orf118	168090	broad.mit.edu	37	chr6	165715113	165715113	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctcccagtgaagtcattcTtcaggagatcttgcttggcg	7	13	11	10	1	4	2	2	1	2	1	5	3	5	2	1	2	2	2	1	2	1	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr6:165715113T>C	uc003qum.3	-	2	734	c.698A>G	c.(697-699)AAG>AGG	p.K233R	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	233											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		GAAGTCATTCTTCAGGAGATC	0.607													3	101					0	0	0	0	C	165715113	C	C	165715113	3	2	14	1	0	0	0	0	1	0	0	0	2333	1609	56	5	743	5	C6orf118	6	165715113	Missense_Mutation	SNP	T	TCGA-BA-5559-01A-01D-1512-08	12968570	165715113	5399954	37	3148											
ASZ1	136991	broad.mit.edu	37	chr7	117007450	117007450	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagaccttttcactcaaatCttcaacattattaaccaatt	14	14	2	11	0	4	1	3	0	1	1	4	1	4	1	2	0	2	1	2	0	5	6			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr7:117007450C>A	uc003vjb.2	-	12	1294	c.1231G>T	c.(1231-1233)GAT>TAT	p.D411Y	ASZ1_uc011kno.1_Missense_Mutation_p.D402Y|ASZ1_uc011knp.1_Missense_Mutation_p.D203Y	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	411					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TCACTCAAATCTTCAACATTA	0.303													4	46					0.00116845	0.00127564	1	0	A	117007450	A	A	117007450	3	1	14	1	0	0	0	0	1	0	0	0	1071	913	32	2	204	2	ASZ1	7	117007450	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08		117007450	42131213	38	3149											
RIMS2	9699	broad.mit.edu	37	chr8	104897724	104897724	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatagggactccaacaggagAagtcataggcattccaaaga	16	7	10	8	0	1	2	1	0	0	2	3	4	3	3	2	3	1	1	2	3	6	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr8:104897724A>G	uc003yls.2	+	2	472	c.231A>G	c.(229-231)AGA>AGG	p.R77R	RIMS2_uc003ylp.2_Silent_p.R299R|RIMS2_uc003ylw.2_Silent_p.R107R|RIMS2_uc003ylq.2_Silent_p.R107R|RIMS2_uc003ylr.2_Silent_p.R107R	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	330					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCAACAGGAGAAGTCATAGGC	0.413										HNSCC(12;0.0054)			4	151					0	0	0	0	G	104897724	G	G	104897724	2	3	14	1	0	0	0	0	0	0	0	1	13433	243	9	5		5	RIMS2	8	104897724	Silent	SNP	A	TCGA-BA-5559-01A-01D-1512-08		104897724	41466298	39	3150											
ASAP1	50807	broad.mit.edu	37	chr8	131127917	131127917	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcatctatctcctcctgtCgaagattccactcatattct	8	16	3	14	1	5	1	2	0	4	1	10	2	7	1	3	0	0	0	3	0	3	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr8:131127917C>T	uc003yta.1	-	22	2157	c.2129G>A	c.(2128-2130)CGA>CAA	p.R710Q	ASAP1_uc003ysz.1_Missense_Mutation_p.R521Q|ASAP1_uc011liw.1_Missense_Mutation_p.R703Q	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	710					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						CTCCTCCTGTCGAAGATTCCA	0.413													32	478					0	0	0	0	T	131127917	T	T	131127917	3	4	14	1	0	0	0	0	1	0	0	0	1012	884	31	1	1292	1	ASAP1	8	131127917	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	26230193	131127917	15236105	40	3151											
TAF1L	138474	broad.mit.edu	37	chr9	32635464	32635464	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttgccgaaaaggataccCgctaaagtaaatgggccacc	14	7	10	10	2	0	0	0	0	0	0	0	2	0	1	4	2	2	3	4	2	7	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr9:32635464C>T	uc003zrg.1	-	1	204	c.114G>A	c.(112-114)GCG>GCA	p.A38A	uc003zrh.1_Intron	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	38					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AAAGGATACCCGCTAAAGTAA	0.567													7	153					0	0	0	0	T	32635464	T	T	32635464	2	4	14	1	0	0	0	0	0	0	0	1	15589	639	23	1		1	TAF1L	9	32635464	Silent	SNP	C	TCGA-BA-5559-01A-01D-1512-08		32635464	108577967	41	3152											
CTSL1	1514	broad.mit.edu	37	chr9	90343233	90343233	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccaggaaggggaaagtgttCcaggaacctctgttttatga	11	10	12	8	0	1	1	0	1	1	0	2	4	2	4	3	4	1	2	3	4	4	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr9:90343233C>T	uc004aph.2	+	4	668	c.318C>T	c.(316-318)TTC>TTT	p.F106F	CTSL1_uc004api.2_Silent_p.F106F|CTSL1_uc004apj.2_Silent_p.F51F|CTSL1_uc010mqh.2_Intron|CTSL1_uc004apk.2_Silent_p.F106F|CTSL1_uc004apl.2_Silent_p.F106F	NM_001912	NP_001903	P07711	CATL1_HUMAN	cathepsin L1 preproprotein	106					macrophage apoptosis|proteolysis	extracellular region|lysosome|nucleus	cysteine-type endopeptidase activity|histone binding			ovary(3)	3					Glucagon recombinant(DB00040)	GGAAAGTGTTCCAGGAACCTC	0.458													15	114					0	0	0	0	T	90343233	T	T	90343233	2	4	14	1	0	0	0	0	0	0	0	1	4055	854	30	2		2	CTSL1	9	90343233	Silent	SNP	C	TCGA-BA-5559-01A-01D-1512-08	57707769	90343233	50870198	42	3153											
OR1L4	254973	broad.mit.edu	37	chr9	125486377	125486377	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcttcctcatcatgtacCtactcactgcggtggggaat	8	12	8	13	1	4	0	3	0	1	0	5	1	5	1	3	3	3	1	3	3	3	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr9:125486377C>A	uc004bmu.1	+	1	109	c.109C>A	c.(109-111)CTA>ATA	p.L37I		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATCATGTACCTACTCACTGC	0.498													15	246					2.61681e-11	3.08318e-11	1	0	A	125486377	A	A	125486377	3	1	14	1	0	0	0	0	1	0	0	0	11019	680	24	4	111	4	OR1L4	9	125486377	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	35143144	125486377	15727054	43	3154											
SLC39A12	221074	broad.mit.edu	37	chr10	18270411	18270411	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccacctaccactctggaGagtaagttctggatcttcct	8	12	8	13	0	3	1	0	0	3	1	4	3	4	2	4	2	2	2	4	2	2	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr10:18270411G>C	uc001ipo.2	+	6	1368	c.1095G>C	c.(1093-1095)GAG>GAC	p.E365D	SLC39A12_uc001ipn.2_Missense_Mutation_p.E365D|SLC39A12_uc001ipp.2_Missense_Mutation_p.E365D|SLC39A12_uc010qck.1_Missense_Mutation_p.E231D	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	365	Cytoplasmic (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						CCACTCTGGAGAGTAAGTTCT	0.393													10	39					0	0	0	0	C	18270411	C	C	18270411	3	2	14	1	0	0	0	0	1	0	0	0	14679	956	33	2	1113	2	SLC39A12	10	18270411	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		18270411	117264336	44	3155											
TET1	80312	broad.mit.edu	37	chr10	70405419	70405419	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgggcaaactactaccctttCcaactcacatatcaactcag	13	10	4	14	0	3	0	3	0	0	0	4	0	4	0	2	1	5	1	2	1	6	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr10:70405419C>G	uc001jok.3	+	4	3438	c.2933C>G	c.(2932-2934)TCC>TGC	p.S978C		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	978					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						ACTACCCTTTCCAACTCACAT	0.363													17	72					0	0	0	0	G	70405419	G	G	70405419	3	3	14	1	0	0	0	0	1	0	0	0	15835	855	30	2	2943	2	TET1	10	70405419	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	52135008	70405419	65129328	45	3156											
PLCE1	51196	broad.mit.edu	37	chr10	95790919	95790919	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtctcagacatcaatatttCaaaagcacatactgtcagac	15	10	6	10	0	4	2	4	0	1	2	5	2	4	2	0	1	2	1	0	1	5	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr10:95790919C>G	uc001kjk.2	+	2	750	c.116C>G	c.(115-117)TCA>TGA	p.S39*	PLCE1_uc010qnx.1_Nonsense_Mutation_p.S39*	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	39					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				ATCAATATTTCAAAAGCACAT	0.423													17	96					0	0	0	0	G	95790919	G	G	95790919	4	3	14	1	0	0	0	0	0	1	0	0	12089	838	29	2	118	2	PLCE1	10	95790919	Nonsense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	25385500	95790919	39743828	46	3157											
SORCS3	22986	broad.mit.edu	37	chr10	107012588	107012588	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgtttcctggtctccccaCttcagcagagcttttcattc	5	15	7	14	1	3	1	2	0	1	1	6	1	4	1	3	1	2	3	3	1	0	5			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr10:107012588C>A	uc001kyi.1	+	23	3388	c.3161C>A	c.(3160-3162)ACT>AAT	p.T1054N	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1054	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGTCTCCCCACTTCAGCAGAG	0.517													30	69					2.49675e-24	3.12751e-24	1	0	A	107012588	A	A	107012588	3	1	14	1	0	0	0	0	1	0	0	0	14996	565	20	4	3251	4	SORCS3	10	107012588	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	11221669	107012588	28522159	47	3158											
MUC5B	727897	broad.mit.edu	37	chr11	1275954	1275954	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accaaattccggtgagcagcGgtttcagcaagaacggcgtg	11	7	13	10	4	1	2	1	1	0	1	2	2	2	2	2	3	4	3	2	3	3	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:1275954G>A	uc009ycr.1	+	57	16645	c.16519G>A	c.(16519-16521)GGT>AGT	p.G5507S	MUC5B_uc001ltb.2_Missense_Mutation_p.G5173S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5170	VWFD 4.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGTGAGCAGCGGTTTCAGCAA	0.607													11	31					0	0	0	0	A	1275954	A	A	1275954	3	1	14	1	0	0	0	0	1	0	0	0	10032	1116	39	1	15655	1	MUC5B	11	1275954	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		1275954	133730562	48	3159											
CARS	833	broad.mit.edu	37	chr11	3061081	3061081	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaccttgtcatcaatatccGtaatgttcatgcaataaaag	14	14	5	8	1	3	0	3	0	0	0	4	0	4	0	2	0	2	3	2	0	7	6			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:3061081G>A	uc001lxh.2	-	4	361	c.287C>T	c.(286-288)ACG>ATG	p.T96M	CARS_uc001lxe.2_Missense_Mutation_p.T86M|CARS_uc001lxf.2_Missense_Mutation_p.T179M|CARS_uc001lxg.2_Missense_Mutation_p.T96M|CARS_uc010qxo.1_Missense_Mutation_p.T179M|CARS_uc010qxp.1_Missense_Mutation_p.T109M|uc001lxi.1_Intron	NM_001751	NP_001742	P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase isoform b	96					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|protein homodimerization activity|tRNA binding|tRNA binding		CARS/ALK(5)	soft_tissue(5)|ovary(2)	7		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	ATCAATATCCGTAATGTTCAT	0.294			T	ALK	ALCL								4	42					0	0	0	0	A	3061081	A	A	3061081	3	1	14	1	0	0	0	0	1	0	0	0	2669	1145	40	1	2043	1	CARS	11	3061081	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	1785127	3061081	131945435	49	3160											
OR51F2	119694	broad.mit.edu	37	chr11	4843392	4843392	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacacctgcacatcccacatCagtgctgtttccatcttcta	10	12	4	15	0	3	0	1	0	2	0	5	0	5	0	3	0	3	3	3	0	2	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:4843392C>A	uc010qyn.1	+	1	777	c.777C>A	c.(775-777)ATC>ATA	p.I259I		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CATCCCACATCAGTGCTGTTT	0.493													22	72					7.45023e-12	8.86577e-12	1	0	A	4843392	A	A	4843392	2	1	14	1	0	0	0	0	0	0	0	1	11151	816	29	2		2	OR51F2	11	4843392	Silent	SNP	C	TCGA-BA-5559-01A-01D-1512-08	1782311	4843392	130163124	50	3161											
MRGPRX1	259249	broad.mit.edu	37	chr11	18955550	18955550	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggcactgctgttaagagcgGacaggaaaatagaaactaga	16	7	12	6	1	0	3	0	0	0	3	0	5	0	5	0	3	3	3	0	3	6	3	rs150108666		TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:18955550G>T	uc001mpg.2	-	1	1000	c.782C>A	c.(781-783)TCC>TAC	p.S261Y		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	261	Helical; Name=7; (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						GTTAAGAGCGGACAGGAAAAT	0.463													33	97					1.61788e-16	1.98482e-16	1	0	T	18955550	T	T	18955550	3	4	14	1	0	0	0	0	1	0	0	0	9819	1174	41	2	190	2	MRGPRX1	11	18955550	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	14112158	18955550	116050966	51	3162											
PAMR1	25891	broad.mit.edu	37	chr11	35454125	35454125	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggttcccagctggcacagaAcatgttatcagtgacactca	11	9	10	11	0	2	2	2	1	0	1	3	2	3	2	1	2	2	4	1	2	2	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:35454125A>G	uc001mwg.2	-	11	1985	c.1942T>C	c.(1942-1944)TTC>CTC	p.F648L	PAMR1_uc001mwf.2_Missense_Mutation_p.F665L|PAMR1_uc010rew.1_Missense_Mutation_p.F537L|PAMR1_uc010rex.1_Missense_Mutation_p.F608L	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	648	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						CTGGCACAGAACATGTTATCA	0.597													15	42					0	0	0	0	G	35454125	G	G	35454125	3	3	14	1	0	0	0	0	1	0	0	0	11467	43	2	5	224	5	PAMR1	11	35454125	Missense_Mutation	SNP	A	TCGA-BA-5559-01A-01D-1512-08	16498575	35454125	99552391	52	3163											
LRP4	4038	broad.mit.edu	37	chr11	46911062	46911062	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtgcgtgcagcctccgttGttgtccccacagcggttttt	4	13	12	12	3	0	0	0	0	0	0	2	0	2	0	4	2	4	4	4	2	0	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:46911062G>T	uc001ndn.3	-	16	2261	c.2115C>A	c.(2113-2115)AAC>AAA	p.N705K		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	705	Extracellular (Potential).|EGF-like 3.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		AGCCTCCGTTGTTGTCCCCAC	0.592											OREG0020948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	118					3.09899e-07	3.61548e-07	1	0	T	46911062	T	T	46911062	3	4	14	1	0	0	0	0	1	0	0	0	9009	1368	48	4	3694	4	LRP4	11	46911062	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	11456937	46911062	88095454	53	3164											
EFEMP2	30008	broad.mit.edu	37	chr11	65638052	65638052	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaccatcagggcaggtgcActgataggagccaggcaagt	12	6	14	9	0	1	1	1	1	0	0	1	2	1	2	2	4	3	4	2	4	3	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:65638052A>T	uc001ofy.3	-	5	639	c.445T>A	c.(445-447)TGC>AGC	p.C149S	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.C149S	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	149	EGF-like 2; calcium-binding (Potential).				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		GGGCAGGTGCACTGATAGGAG	0.622													13	27					0	0	0	0	T	65638052	T	T	65638052	3	4	14	1	0	0	0	0	1	0	0	0	4964	159	6	5	914	5	EFEMP2	11	65638052	Missense_Mutation	SNP	A	TCGA-BA-5559-01A-01D-1512-08	18726990	65638052	69368464	54	3165											
HYOU1	10525	broad.mit.edu	37	chr11	118925377	118925377	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acggtgatcactgcatccttGatgggctgctctacagatga	9	11	11	10	1	2	4	1	3	1	1	3	4	3	4	1	2	3	3	1	2	1	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr11:118925377G>A	uc001puu.2	-	7	700	c.507C>T	c.(505-507)ATC>ATT	p.I169I	HYOU1_uc001put.2_Silent_p.I134I|HYOU1_uc010ryu.1_Silent_p.I189I|HYOU1_uc010ryv.1_Silent_p.I58I|HYOU1_uc001pux.3_Silent_p.I169I|HYOU1_uc010ryw.1_RNA|HYOU1_uc001puw.1_Silent_p.I169I	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	169						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		CTGCATCCTTGATGGGCTGCT	0.458													9	26					0	0	0	0	A	118925377	A	A	118925377	2	1	14	1	0	0	0	0	0	0	0	1	7509	1280	45	2		2	HYOU1	11	118925377	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	53287325	118925377	16081139	55	3166											
LPAR5	57121	broad.mit.edu	37	chr12	6729533	6729533	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgctaaagtagtacaccagCgggtccagcacgcagttggc	10	6	13	12	3	0	0	0	0	0	0	1	0	1	0	2	2	3	6	2	2	4	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:6729533C>T	uc009zer.2	-	2	1163	c.882G>A	c.(880-882)CCG>CCA	p.P294P	LPAR5_uc001qps.2_Silent_p.P294P|LPAR5_uc010sff.1_Silent_p.P294P	NM_001142961	NP_001136433	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	294	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2						AGTACACCAGCGGGTCCAGCA	0.726													12	25					0	0	0	0	T	6729533	T	T	6729533	2	4	14	1	0	0	0	0	0	0	0	1	8958	755	27	1		1	LPAR5	12	6729533	Silent	SNP	C	TCGA-BA-5559-01A-01D-1512-08		6729533	127122362	56	3167											
CLEC1A	51267	broad.mit.edu	37	chr12	10233841	10233841	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaggacacacttacctccaGctttgttatacagctcacga	11	10	6	14	1	1	0	1	0	0	0	2	2	2	1	3	1	4	3	3	1	3	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:10233841G>A	uc001qxb.2	-	3	470	c.386C>T	c.(385-387)GCT>GTT	p.A129V	CLEC1A_uc009zhf.2_Missense_Mutation_p.A41V|CLEC1A_uc001qxc.2_Missense_Mutation_p.A41V|CLEC1A_uc001qxd.2_Missense_Mutation_p.A86V|CLEC1A_uc010sgx.1_Intron	NM_016511	NP_057595	Q8NC01	CLC1A_HUMAN	C-type lectin-like receptor-1	129	Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2						CTTACCTCCAGCTTTGTTATA	0.453													13	264					0	0	0	0	A	10233841	A	A	10233841	3	1	14	1	0	0	0	0	1	0	0	0	3520	971	34	4	472	4	CLEC1A	12	10233841	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	3504308	10233841	123618054	57	3168											
PRB3	5544	broad.mit.edu	37	chr12	11421068	11421068	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcctccttgtgggcgtcGtccttctggctttcctggag	1	16	12	12	2	1	0	0	0	1	0	6	1	5	1	4	3	0	2	4	3	0	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:11421068G>A	uc001qzs.2	-	3	153	c.115C>T	c.(115-117)CGA>TGA	p.R39*	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	39	Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TGTGGGCGTCGTCCTTCTGGC	0.547													22	190					0	0	0	0	A	11421068	A	A	11421068	4	1	14	1	0	0	0	0	0	1	0	0	12506	1153	40	1	822	1	PRB3	12	11421068	Nonsense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	1187227	11421068	122430827	58	3169											
PCBP2	5094	broad.mit.edu	37	chr12	53849269	53849269	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagaatcagttaagaagatgCgcgaggaggtaagttatgaa	16	8	14	3	2	1	4	1	1	0	3	1	7	1	5	0	2	1	3	0	2	6	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:53849269C>T	uc001sdl.3	+	4	468	c.118C>T	c.(118-120)CGC>TGC	p.R40C	PCBP2_uc001sdc.3_Missense_Mutation_p.R40C|PCBP2_uc001sdb.3_Missense_Mutation_p.R40C|PCBP2_uc001sde.3_Missense_Mutation_p.R40C|PCBP2_uc001sdi.3_Missense_Mutation_p.R40C|PCBP2_uc001sdd.3_Missense_Mutation_p.R40C|PCBP2_uc001sdf.3_Missense_Mutation_p.R40C|PCBP2_uc009zna.2_Missense_Mutation_p.R40C|PCBP2_uc010soh.1_Missense_Mutation_p.R40C|PCBP2_uc009zmz.1_Intron	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	40	KH 1.				innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						TAAGAAGATGCGCGAGGAGGT	0.348													4	138					0	0	0	0	T	53849269	T	T	53849269	3	4	14	1	0	0	0	0	1	0	0	0	11555	768	27	1	128	1	PCBP2	12	53849269	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	42428201	53849269	80002626	59	3170											
NEDD1	121441	broad.mit.edu	37	chr12	97331091	97331091	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aattgtcagagaagcacctgCcacgtccattgccacagttc	11	9	8	13	1	1	1	1	0	0	1	3	2	2	1	4	0	3	2	4	0	2	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:97331091C>T	uc001teu.3	+	9	1376	c.1037C>T	c.(1036-1038)GCC>GTC	p.A346V	NEDD1_uc001tev.3_Missense_Mutation_p.A346V|NEDD1_uc010svc.1_Missense_Mutation_p.A257V|NEDD1_uc001tew.2_Missense_Mutation_p.A353V|NEDD1_uc001tex.2_Missense_Mutation_p.A257V	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	346					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						GAAGCACCTGCCACGTCCATT	0.433													104	109					0	0	0	0	T	97331091	T	T	97331091	3	4	14	1	0	0	0	0	1	0	0	0	10363	739	26	4	1088	4	NEDD1	12	97331091	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	43481822	97331091	36520804	60	3171											
SSH1	54434	broad.mit.edu	37	chr12	109182226	109182226	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaagaaaggaggggggctCttcagtgagcctccttccaa	11	8	13	9	0	2	3	1	1	1	2	4	4	4	4	3	4	1	1	3	4	4	3	rs148301801		TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:109182226C>A	uc001tnm.2	-	15	2775	c.2688G>T	c.(2686-2688)AAG>AAT	p.K896N	SSH1_uc001tnl.2_Missense_Mutation_p.K584N	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	896					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						GAGGGGGGCTCTTCAGTGAGC	0.597													26	72					3.6726e-16	4.45959e-16	1	0	A	109182226	A	A	109182226	3	1	14	1	0	0	0	0	1	0	0	0	15250	912	32	2	465	2	SSH1	12	109182226	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	11851135	109182226	24669669	61	3172											
RIMBP2	23504	broad.mit.edu	37	chr12	130927171	130927171	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaaagtccacgaagttggaGggcaccagacccctctggcc	11	5	11	14	1	1	1	0	0	1	1	2	3	2	2	5	3	0	2	5	3	2	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr12:130927171G>A	uc001uil.2	-	8	839	c.675C>T	c.(673-675)CCC>CCT	p.P225P	RIMBP2_uc001uim.2_Silent_p.P133P|RIMBP2_uc001uin.1_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	225	SH3 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CGAAGTTGGAGGGCACCAGAC	0.597													34	46					0	0	0	0	A	130927171	A	A	130927171	2	1	14	1	0	0	0	0	0	0	0	1	13428	987	35	4		4	RIMBP2	12	130927171	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	21744945	130927171	2924724	62	3173											
INTS6	26512	broad.mit.edu	37	chr13	51957877	51957877	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggatgagatgtacgaggtgGctaaaggggaaagtcttgta	13	9	16	3	1	1	1	0	1	1	1	1	5	1	3	0	5	1	3	0	5	5	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr13:51957877G>A	uc001vfk.2	-	8	1509	c.895C>T	c.(895-897)CCA>TCA	p.P299S	INTS6_uc001vfi.2_5'UTR|INTS6_uc001vfj.2_Missense_Mutation_p.P286S|INTS6_uc001vfl.2_Missense_Mutation_p.P121S	NM_012141	NP_036273	Q9UL03	INT6_HUMAN	integrator complex subunit 6 isoform a	299					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			ovary(1)|lung(1)	2		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		GTACGAGGTGGCTAAAGGGGA	0.353													10	91					0	0	0	0	A	51957877	A	A	51957877	3	1	14	1	0	0	0	0	1	0	0	0	7821	1217	42	4	1812	4	INTS6	13	51957877	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		51957877	63212001	63	3174											
ATP7B	540	broad.mit.edu	37	chr13	52548430	52548430	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatagccctctgcagagccActgggctggtacaagaaggg	10	6	14	11	1	1	2	0	0	1	2	1	3	1	2	2	3	4	3	2	3	4	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr13:52548430A>G	uc001vfw.2	-	2	1083	c.926T>C	c.(925-927)GTG>GCG	p.V309A	ATP7B_uc010adv.2_Missense_Mutation_p.V309A|ATP7B_uc001vfx.2_Missense_Mutation_p.V309A|ATP7B_uc001vfy.2_Intron|ATP7B_uc010tgt.1_Missense_Mutation_p.V309A|ATP7B_uc010tgu.1_Missense_Mutation_p.V309A|ATP7B_uc010tgv.1_Missense_Mutation_p.V309A|ATP7B_uc010tgw.1_Missense_Mutation_p.V277A	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	309	HMA 3.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CTGCAGAGCCACTGGGCTGGT	0.488									Wilson_disease				23	109					0	0	0	0	G	52548430	G	G	52548430	3	3	14	1	0	0	0	0	1	0	0	0	1193	159	6	5	3551	5	ATP7B	13	52548430	Missense_Mutation	SNP	A	TCGA-BA-5559-01A-01D-1512-08	590553	52548430	62621448	64	3175											
OR11H4	390442	broad.mit.edu	37	chr14	20711912	20711912	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtttggaatgagaattcGtcaaaattcgtgagccaaag	13	11	10	7	2	1	2	1	2	0	1	3	4	1	3	2	1	1	1	2	1	5	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr14:20711912G>A	uc010tld.1	+	1	962	c.962G>A	c.(961-963)CGT>CAT	p.R321H		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	321	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		ATGAGAATTCGTCAAAATTCG	0.393													39	80					0	0	0	0	A	20711912	A	A	20711912	3	1	14	1	0	0	0	0	1	0	0	0	10982	1145	40	1	964	1	OR11H4	14	20711912	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		20711912	86637628	65	3176											
PLEK2	26499	broad.mit.edu	37	chr14	67864498	67864498	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagtacaccagcgtgttctGccgaaggatgaaccatcgcg	10	8	12	11	4	1	1	0	1	1	0	2	3	1	2	3	1	4	3	3	1	4	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr14:67864498G>A	uc001xjh.1	-	2	140	c.88C>T	c.(88-90)CAG>TAG	p.Q30*		NM_016445	NP_057529	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	30	PH 1.				actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				ovary(1)|pancreas(1)	2				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		AGCGTGTTCTGCCGAAGGATG	0.602													9	24					0	0	0	0	A	67864498	A	A	67864498	4	1	14	1	0	0	0	0	0	1	0	0	12109	1328	46	4	1005	4	PLEK2	14	67864498	Nonsense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	47152586	67864498	39485042	66	3177											
SGK269	79834	broad.mit.edu	37	chr15	77407481	77407481	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttggcgtcttcttcagtctCttccatgtcatcctcatcct	4	18	5	14	1	6	0	3	0	3	0	10	0	9	0	3	1	0	0	3	1	0	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr15:77407481C>G	uc002bcm.2	-	6	4566	c.4258G>C	c.(4258-4260)GAG>CAG	p.E1420Q		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1420	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TCTTCAGTCTCTTCCATGTCA	0.498													6	160					0	0	0	0	G	77407481	G	G	77407481	3	3	14	1	0	0	0	0	1	0	0	0	14276	922	32	2	986	2	SGK269	15	77407481	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08		77407481	25123911	67	3178											
TTC23	64927	broad.mit.edu	37	chr15	99762036	99762036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaaattcttgtcagtgctaCgcaacgcacaagctcatgga	12	9	9	11	2	3	0	2	0	1	0	3	1	3	1	0	1	4	5	0	1	4	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr15:99762036C>T	uc002bur.2	-	5	745	c.214G>A	c.(214-216)GTA>ATA	p.V72I	TTC23_uc002bus.2_Missense_Mutation_p.V72I|TTC23_uc002but.2_Missense_Mutation_p.V72I|TTC23_uc002buu.2_Missense_Mutation_p.V72I|TTC23_uc002buv.2_Missense_Mutation_p.V72I|TTC23_uc002bux.2_Missense_Mutation_p.V72I|TTC23_uc002buw.2_Missense_Mutation_p.V72I|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Missense_Mutation_p.V72I|TTC23_uc010bor.2_Missense_Mutation_p.V72I|TTC23_uc002buz.2_Missense_Mutation_p.V72I	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	72	TPR 1.						binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			GTCAGTGCTACGCAACGCACA	0.448													14	48					0	0	0	0	T	99762036	T	T	99762036	3	4	14	1	0	0	0	0	1	0	0	0	16758	536	19	1	1165	1	TTC23	15	99762036	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	22354555	99762036	2769356	68	3179											
ACSM2B	348158	broad.mit.edu	37	chr16	20565101	20565101	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaagagctcagcttacccAgcatccatcttggccttgag	11	9	9	12	0	2	3	1	1	1	2	3	3	3	3	3	1	4	3	3	1	2	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:20565101A>C	uc002dhj.3	-	6	948	c.738T>G	c.(736-738)GCT>GCG	p.A246A	ACSM2B_uc002dhk.3_Silent_p.A246A|ACSM2B_uc010bwf.1_Silent_p.A246A	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	246					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CAGCTTACCCAGCATCCATCT	0.512													27	104					0	0	0	0	C	20565101	C	C	20565101	2	2	14	1	0	0	0	0	0	0	0	1	184	175	7	5		5	ACSM2B	16	20565101	Silent	SNP	A	TCGA-BA-5559-01A-01D-1512-08		20565101	69789652	69	3180											
EARS2	124454	broad.mit.edu	37	chr16	23541092	23541092	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcaggaggatcctctccacGtagactgggttgaggacatc	10	8	13	10	1	1	2	0	1	1	1	4	5	2	5	2	4	1	3	2	4	1	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:23541092G>A	uc002dlt.3	-	6	1226	c.1194C>T	c.(1192-1194)TAC>TAT	p.Y398Y	EARS2_uc002dlr.3_RNA|EARS2_uc002dls.3_RNA|EARS2_uc002dlu.2_Silent_p.Y398Y	NM_001083614	NP_001077083	Q5JPH6	SYEM_HUMAN	glutamyl-tRNA synthetase 2 precursor	398					glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding				0				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)	TCCTCTCCACGTAGACTGGGT	0.592													27	181					0	0	0	0	A	23541092	A	A	23541092	2	1	14	1	0	0	0	0	0	0	0	1	4900	1140	40	1		1	EARS2	16	23541092	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	2975991	23541092	66813661	70	3181											
CYLD	1540	broad.mit.edu	37	chr16	50811826	50811826	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacaaccacaatccaaatCaaaaaatacatggtacattg	19	8	3	11	0	2	0	2	0	0	0	3	0	3	0	2	1	3	1	2	1	8	3			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:50811826C>A	uc002egp.1	+	8	1527	c.1112C>A	c.(1111-1113)TCA>TAA	p.S371*	CYLD_uc002egn.1_Nonsense_Mutation_p.S368*|CYLD_uc002ego.2_Nonsense_Mutation_p.S368*|CYLD_uc010cbs.1_Nonsense_Mutation_p.S368*|CYLD_uc002egq.1_Nonsense_Mutation_p.S368*|CYLD_uc002egr.1_Nonsense_Mutation_p.S368*|CYLD_uc002egs.1_Nonsense_Mutation_p.S368*	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	371	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding	p.S371*(1)		skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				CAATCCAAATCAAAAAATACA	0.313			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				7	126					8.12818e-05	9.03976e-05	1	0	A	50811826	A	A	50811826	4	1	14	1	0	0	0	0	0	1	0	0	4160	838	29	2	1134	2	CYLD	16	50811826	Nonsense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	27270734	50811826	39542927	71	3182											
GPR56	9289	broad.mit.edu	37	chr16	57689388	57689388	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggacgaaaggccggagcggGgaggctgagaagagactcct	12	3	18	8	3	0	2	0	1	0	2	1	8	1	5	2	6	1	1	2	6	2	0			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:57689388G>A	uc002emb.2	+	7	1138	c.846G>A	c.(844-846)GGG>GGA	p.G282G	GPR56_uc002elz.1_Silent_p.G112G|GPR56_uc002ema.1_Silent_p.G107G|GPR56_uc002emc.2_Silent_p.G282G|GPR56_uc002emf.2_Silent_p.G282G|GPR56_uc010vhs.1_Silent_p.G282G|GPR56_uc002emd.2_Silent_p.G282G|GPR56_uc002eme.2_Silent_p.G282G|GPR56_uc010vht.1_Silent_p.G287G|GPR56_uc002emg.3_Silent_p.G282G|GPR56_uc010vhu.1_Silent_p.G107G	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	282	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						GCCGGAGCGGGGAGGCTGAGA	0.587													7	40					0	0	0	0	A	57689388	A	A	57689388	2	1	14	1	0	0	0	0	0	0	0	1	6738	1219	43	4		4	GPR56	16	57689388	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	6877562	57689388	32665365	72	3183											
CDH11	1009	broad.mit.edu	37	chr16	65032522	65032522	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcgtgcaggaactccggagGgttgtcattaatgtcctgga	8	11	13	9	2	1	0	1	0	0	0	4	3	3	3	2	4	2	2	2	4	2	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:65032522G>T	uc002eoi.2	-	4	900	c.466C>A	c.(466-468)CCT>ACT	p.P156T	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Missense_Mutation_p.P156T|CDH11_uc010vin.1_Missense_Mutation_p.P30T|CDH11_uc010vio.1_Missense_Mutation_p.P156T	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	156	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AACTCCGGAGGGTTGTCATTA	0.587			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			9	95					7.48243e-07	8.64475e-07	1	0	T	65032522	T	T	65032522	3	4	14	1	0	0	0	0	1	0	0	0	3112	1232	43	4	1964	4	CDH11	16	65032522	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	7343134	65032522	25322231	73	3184											
TMCO7	79613	broad.mit.edu	37	chr16	68912102	68912102	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactacctttataactttgTcaagagaacgcccacatttg	12	12	5	12	1	1	1	1	0	0	1	1	2	1	1	3	0	3	0	3	0	5	6			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr16:68912102T>C	uc002ewi.3	+	6	1225	c.1213T>C	c.(1213-1215)TCA>CCA	p.S405P		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	405						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		TATAACTTTGTCAAGAGAACG	0.403													3	45					0	0	0	0	C	68912102	C	C	68912102	3	2	14	1	0	0	0	0	1	0	0	0	16067	1667	58	5	1235	5	TMCO7	16	68912102	Missense_Mutation	SNP	T	TCGA-BA-5559-01A-01D-1512-08	3879580	68912102	21442651	74	3185											
PIK3R5	23533	broad.mit.edu	37	chr17	8812440	8812440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaggataaggaagtggcccGggtccctgctgaccagctcc	8	6	15	12	1	0	1	0	1	0	0	2	4	2	4	4	5	2	2	4	5	2	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr17:8812440G>A	uc002glt.2	-	3	222	c.155C>T	c.(154-156)CCG>CTG	p.P52L	PIK3R5_uc010vuz.1_Missense_Mutation_p.P52L|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Missense_Mutation_p.P52L|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	52	Heterodimerization (By similarity).				platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GAAGTGGCCCGGGTCCCTGCT	0.592													3	30					0	0	0	0	A	8812440	A	A	8812440	3	1	14	1	0	0	0	0	1	0	0	0	11977	1116	39	1	2555	1	PIK3R5	17	8812440	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		8812440	72382770	75	3186											
KRT38	8687	broad.mit.edu	37	chr17	39593678	39593678	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaattcagaatcggcttcCggtggtgctggctccacagg	8	9	14	10	2	1	1	1	0	0	1	4	2	3	2	2	6	1	3	2	6	2	2	rs148086126	byFrequency	TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr17:39593678C>T	uc002hwq.1	-	7	1780	c.1357G>A	c.(1357-1359)GGA>AGA	p.G453R		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	453	Tail.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				AATCGGCTTCCGGTGGTGCTG	0.592													8	9					0	0	0	0	T	39593678	T	T	39593678	3	4	14	1	0	0	0	0	1	0	0	0	8514	661	23	1	17	1	KRT38	17	39593678	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	30781238	39593678	41601532	76	3187											
BRIP1	83990	broad.mit.edu	37	chr17	59876570	59876570	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaccgaagctgaacttctgTtacactgtaacttgctgatt	12	13	7	9	1	1	2	0	2	1	0	1	3	1	2	1	0	6	4	1	0	5	5			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr17:59876570T>C	uc002izk.1	-	9	1372	c.1231A>G	c.(1231-1233)ACA>GCA	p.T411A		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	411	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						TGAACTTCTGTTACACTGTAA	0.398			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				37	135					0	0	0	0	C	59876570	C	C	59876570	3	2	14	1	0	0	0	0	1	0	0	0	1519	1725	60	5	2566	5	BRIP1	17	59876570	Missense_Mutation	SNP	T	TCGA-BA-5559-01A-01D-1512-08	20282892	59876570	21318640	77	3188											
SLC25A19	60386	broad.mit.edu	37	chr17	73282528	73282528	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggggtcactgcgagacaggcGctcatgctgaagctaggaat	10	7	15	9	2	2	2	2	1	0	1	2	4	2	3	0	4	3	3	0	4	3	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr17:73282528G>A	uc002jns.3	-	2	1055	c.145C>T	c.(145-147)CGC>TGC	p.R49C	SLC25A19_uc010dge.2_Missense_Mutation_p.R49C|SLC25A19_uc002jnv.3_Missense_Mutation_p.R49C|SLC25A19_uc002jnu.3_Missense_Mutation_p.R49C|SLC25A19_uc002jnw.3_Missense_Mutation_p.R49C|SLC25A19_uc002jnt.3_Missense_Mutation_p.R49C	NM_021734	NP_068380	Q9HC21	TPC_HUMAN	solute carrier family 25, member 19	49	Solcar 1.					integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			ovary(1)	1	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			CGAGACAGGCGCTCATGCTGA	0.532													4	118					0	0	0	0	A	73282528	A	A	73282528	3	1	14	1	0	0	0	0	1	0	0	0	14545	1087	38	1	837	1	SLC25A19	17	73282528	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	13405958	73282528	7912682	78	3189											
LAMA1	284217	broad.mit.edu	37	chr18	7080343	7080343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtgggtttcggacgggccGacctggcacatgctccacaa	7	8	13	13	3	0	0	0	0	0	0	2	2	1	1	3	4	1	3	3	4	1	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr18:7080343G>A	uc002knm.2	-	2	269	c.175C>T	c.(175-177)CGG>TGG	p.R59W	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	59	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGACGGGCCGACCTGGCACA	0.547													72	110					0	0	0	0	A	7080343	A	A	7080343	3	1	14	1	0	0	0	0	1	0	0	0	8645	1057	37	1	9300	1	LAMA1	18	7080343	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		7080343	70996905	79	3190											
MC2R	4158	broad.mit.edu	37	chr18	13885277	13885277	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctcaatatgatcaggatatTttccaagatcttatataggc	13	15	6	7	0	3	2	2	1	2	1	5	3	4	3	1	2	0	0	1	2	7	7			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr18:13885277T>A	uc002ksp.1	-	2	418	c.241A>T	c.(241-243)AAT>TAT	p.N81Y		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	81	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	ATCAGGATATTTTCCAAGATC	0.448													108	43					0	0	0	0	A	13885277	A	A	13885277	3	1	14	1	0	0	0	0	1	0	0	0	9417	1841	64	5	656	5	MC2R	18	13885277	Missense_Mutation	SNP	T	TCGA-BA-5559-01A-01D-1512-08	6804934	13885277	64191971	80	3191											
ZNF407	55628	broad.mit.edu	37	chr18	72343784	72343784	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttggcaaaacacatctccGtcgtcagaatctggctgctc	9	11	8	13	2	4	1	1	0	3	1	7	1	4	1	1	2	2	3	1	2	3	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr18:72343784G>A	uc002llw.2	+	1	866	c.809G>A	c.(808-810)CGT>CAT	p.R270H	ZNF407_uc010xfc.1_Missense_Mutation_p.R270H|ZNF407_uc010dqu.1_Missense_Mutation_p.R270H|ZNF407_uc002llu.2_Missense_Mutation_p.R269H	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		ACACATCTCCGTCGTCAGAAT	0.403													11	195					0	0	0	0	A	72343784	A	A	72343784	3	1	14	1	0	0	0	0	1	0	0	0	17954	1145	40	1	811	1	ZNF407	18	72343784	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	58458507	72343784	5733464	81	3192											
ZNF208	7757	broad.mit.edu	37	chr19	22156525	22156525	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttatgttccataaggtttgaGgaccagttgaaagctttgcc	10	14	10	7	0	0	2	0	2	0	0	1	3	1	3	3	2	2	4	3	2	3	6			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr19:22156525G>A	uc002nqp.2	-	4	1460	c.1311C>T	c.(1309-1311)TCC>TCT	p.S437S	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAAGGTTTGAGGACCAGTTGA	0.378													11	169					0	0	0	0	A	22156525	A	A	22156525	2	1	14	1	0	0	0	0	0	0	0	1	17833	987	35	4		4	ZNF208	19	22156525	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08		22156525	36972458	82	3193											
BLVRB	645	broad.mit.edu	37	chr19	40971542	40971542	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcaccgcctgcgccagggtGgtgagcccggtctggccagt	4	7	16	14	3	1	1	0	1	1	0	1	1	1	1	5	4	3	1	5	4	0	0			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr19:40971542G>A	uc002onw.2	-	1	184	c.54C>T	c.(52-54)ACC>ACT	p.T18T	SPTBN4_uc002onx.2_5'Flank|SPTBN4_uc002ony.2_5'Flank|SPTBN4_uc002onz.2_5'Flank|BLVRB_uc010egw.1_RNA	NM_000713	NP_000704	P30043	BLVRB_HUMAN	biliverdin reductase B (flavin reductase	18					heme catabolic process	cytosol	biliverdin reductase activity|binding|flavin reductase activity				0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)		NADH(DB00157)|Riboflavin(DB00140)	GCGCCAGGGTGGTGAGCCCGG	0.687													11	26					0	0	0	0	A	40971542	A	A	40971542	2	1	14	1	0	0	0	0	0	0	0	1	1455	1335	47	4		4	BLVRB	19	40971542	Silent	SNP	G	TCGA-BA-5559-01A-01D-1512-08	18815017	40971542	18157441	83	3194											
ZNF610	162963	broad.mit.edu	37	chr19	52857030	52857030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctttatacagggacgtgatGttggagaactacaggaacct	12	10	12	7	1	0	2	0	1	0	1	0	5	0	4	1	3	4	2	1	3	5	5			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr19:52857030G>A	uc002pyx.3	+	4	565	c.159G>A	c.(157-159)ATG>ATA	p.M53I	ZNF610_uc002pyy.3_Missense_Mutation_p.M53I|ZNF610_uc002pyz.3_Missense_Mutation_p.M53I|ZNF610_uc002pza.2_Missense_Mutation_p.M53I	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	53	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GGGACGTGATGTTGGAGAACT	0.512													26	203					0	0	0	0	A	52857030	A	A	52857030	3	1	14	1	0	0	0	0	1	0	0	0	18103	1377	48	4	165	4	ZNF610	19	52857030	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	11885488	52857030	6271953	84	3195											
ZNF71	58491	broad.mit.edu	37	chr19	57132929	57132929	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtgtcctggtcccaccaCggctggacgaccccacagaa	8	6	11	16	2	0	1	0	0	0	1	2	3	2	2	5	3	0	2	5	3	1	0			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr19:57132929C>T	uc002qnm.3	+	3	512	c.274C>T	c.(274-276)CGG>TGG	p.R92W		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	92						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GGTCCCACCACGGCTGGACGA	0.582													5	82					0	0	0	0	T	57132929	T	T	57132929	3	4	14	1	0	0	0	0	1	0	0	0	18181	527	19	1	276	1	ZNF71	19	57132929	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	4275899	57132929	1996054	85	3196											
ZNF835	90485	broad.mit.edu	37	chr19	57175917	57175917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcgtagggccgctcgcccGtgtgcacgcgccggtgctgg	3	6	17	15	8	0	0	0	0	0	0	1	0	0	0	3	3	2	4	3	3	1	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr19:57175917G>A	uc010ygo.1	-	2	716	c.716C>T	c.(715-717)ACG>ATG	p.T239M	ZNF835_uc010ygn.1_Missense_Mutation_p.T217M	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CCGCTCGCCCGTGTGCACGCG	0.711													7	18					0	0	0	0	A	57175917	A	A	57175917	3	1	14	1	0	0	0	0	1	0	0	0	18253	1145	40	1	965	1	ZNF835	19	57175917	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08	42988	57175917	1953066	86	3197											
ITCH	83737	broad.mit.edu	37	chr20	33033193	33033193	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actggaatccgtccggaactAtgaacaatggcagctacagc	13	7	10	11	2	0	1	0	1	0	0	2	3	2	3	2	3	5	2	2	3	6	2			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr20:33033193A>G	uc010geu.1	+	12	1382	c.1190A>G	c.(1189-1191)TAT>TGT	p.Y397C	ITCH_uc002xak.2_Missense_Mutation_p.Y356C|ITCH_uc010zuj.1_Missense_Mutation_p.Y246C	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	397	Required for interaction with FYN.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						GTCCGGAACTATGAACAATGG	0.458													85	137					0	0	0	0	G	33033193	G	G	33033193	3	3	14	1	0	0	0	0	1	0	0	0	7907	449	16	5	1101	5	ITCH	20	33033193	Missense_Mutation	SNP	A	TCGA-BA-5559-01A-01D-1512-08		33033193	29992327	87	3198											
ZHX3	23051	broad.mit.edu	37	chr20	39831282	39831285	+	Frame_Shift_Del	DEL	GTTT	-	-																															gcctgggagctgctctgccaGtttgtttgactcatcatcct																										TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr20:39831282_39831285delGTTT	uc002xjs.1	-	3	2650_2653	c.2272_2275delAAAC	c.(2272-2277)AAACTGfs	p.K758fs	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Frame_Shift_Del_p.K758fs|ZHX3_uc002xjt.1_Frame_Shift_Del_p.K758fs|ZHX3_uc002xju.1_Frame_Shift_Del_p.K758fs|ZHX3_uc002xjv.1_Frame_Shift_Del_p.K758fs|ZHX3_uc002xjw.1_Frame_Shift_Del_p.K758fs|ZHX3_uc010ggg.1_Frame_Shift_Del_p.K758fs	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	758_759					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				TGCTCTGCCAGTTTGTTTGACTCA	0.544													---	---	---								-	39831285	-	-	39831282	7	5	14	1	0	1	0	1	0	0	0	0	17744	1020	36	0	603	0	ZHX3	20	39831282	Frame_Shift_Del	DEL	GTTT	TCGA-BA-5559-01A-01D-1512-08	6798089	39831282	23194238	88	3199											
COL6A2	1292	broad.mit.edu	37	chr21	47545457	47545457	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgggtacaccaacttcaCactggagaagaacttcgtca	13	9	8	11	1	2	2	2	0	0	2	3	3	2	2	1	2	3	1	1	2	4	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr21:47545457C>A	uc002zia.1	+	25	1977	c.1895C>A	c.(1894-1896)ACA>AAA	p.T632K	COL6A2_uc002zhy.1_Missense_Mutation_p.T632K|COL6A2_uc002zhz.1_Missense_Mutation_p.T632K|COL6A2_uc002zib.1_Missense_Mutation_p.T38K|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	632	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACCAACTTCACACTGGAGAAG	0.617													3	42					0.004672	0.00505425	1	0	A	47545457	A	A	47545457	3	1	14	1	0	0	0	0	1	0	0	0	3715	478	17	4	1989	4	COL6A2	21	47545457	Missense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08		47545457	584438	89	3200											
EP300	2033	broad.mit.edu	37	chr22	41553402	41553402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaagccttggatactgttGtggcagaaaggtaagaaatg	14	9	13	5	0	0	2	0	0	0	2	0	3	0	3	1	3	2	4	1	3	5	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chr22:41553402G>A	uc003azl.3	+	18	3886	c.3491G>A	c.(3490-3492)TGT>TAT	p.C1164Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1164					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGATACTGTTGTGGCAGAAAG	0.393			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				113	70					0	0	0	0	A	41553402	A	A	41553402	3	1	14	1	0	0	0	0	1	0	0	0	5172	1377	48	4	3561	4	EP300	22	41553402	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		41553402	9751164	90	3201											
OR13H1	347468	broad.mit.edu	37	chrX	130678201	130678201	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatctttcttattcactttGaccccaacctccacactcca	9	14	2	16	0	3	2	1	2	2	0	5	2	5	2	5	0	1	0	5	0	2	4			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chrX:130678201G>A	uc011muw.1	+	1	154	c.154G>A	c.(154-156)GAC>AAC	p.D52N	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					TATTCACTTTGACCCCAACCT	0.413													61	177					0	0	0	0	A	130678201	A	A	130678201	3	1	14	1	0	0	0	0	1	0	0	0	10997	1290	45	2	156	2	OR13H1	23	130678201	Missense_Mutation	SNP	G	TCGA-BA-5559-01A-01D-1512-08		130678201	24592359	91	3202											
IL9R	3581	broad.mit.edu	37	chrX	155232635	155232635	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggctcctggcctgcatctgCatctgcacctgtgtctgctt	3	14	10	14	0	3	0	0	0	3	0	4	0	4	0	3	2	4	5	3	2	0	1			TCGA-BA-5559-01A-01D-1512-08	TCGA-BA-5559-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0845927-fc9a-41b2-9431-619952878e18	ca4aefda-8e9e-416d-8d0a-d0be49d62753	g.chrX:155232635C>A	uc004fnv.1	+	2	272	c.93C>A	c.(91-93)TGC>TGA	p.C31*	IL9R_uc010nvn.2_Nonsense_Mutation_p.C10*|IL9R_uc004fnu.1_Nonsense_Mutation_p.C78*	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	31					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCTGCATCTGCATCTGCACCT	0.597													51	134					6.14515e-18	7.61742e-18	1	0	A	155232635	A	A	155232635	4	1	14	1	0	0	0	0	0	1	0	0	7747	718	25	4	99	4	IL9R	23	155232635	Nonsense_Mutation	SNP	C	TCGA-BA-5559-01A-01D-1512-08	24554434	155232635	37925	92	3203											
PRDM2	7799	broad.mit.edu	37	chr1	14108768	14108768	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaaaaaaaagtttctcattCatctaagaaaggtggacact	18	10	6	7	0	3	1	2	0	2	1	4	2	3	2	0	2	0	1	0	2	6	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:14108768C>T	uc001avi.2	+	8	5334	c.4478C>T	c.(4477-4479)TCA>TTA	p.S1493L	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.S1493L|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Missense_Mutation_p.S1292L|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1493						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GTTTCTCATTCATCTAAGAAA	0.448													56	161					0	0	0	0	T	14108768	T	T	14108768	3	4	15	1	0	0	0	0	1	0	0	0	12520	838	29	2	4504	2	PRDM2	1	14108768	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08		14108768	235141853	1	3204											
CROCC	9696	broad.mit.edu	37	chr1	17275397	17275397	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagccgaggggcaggccctgCtgctggccaaggagaccctg	8	4	16	13	1	0	1	0	0	0	1	0	3	0	1	4	5	3	3	4	5	2	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:17275397C>T	uc001azt.2	+	19	2881	c.2812C>T	c.(2812-2814)CTG>TTG	p.L938L	CROCC_uc009voz.1_Intron|CROCC_uc001azu.2_Silent_p.L241L	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	938	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCAGGCCCTGCTGCTGGCCAA	0.677													5	67					0	0	0	0	T	17275397	T	T	17275397	2	4	15	1	0	0	0	0	0	0	0	1	3908	796	28	4		4	CROCC	1	17275397	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	3166629	17275397	231975224	2	3205											
ZMYM6	9204	broad.mit.edu	37	chr1	35452758	35452759	+	Frame_Shift_Ins	INS	-	A	A																															ggaattaaagatgtgactgcINSaagtcttagggcagggccag																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:35452758_35452759insA	uc001byh.2	-	16	4152_4153	c.3924_3925insT	c.(3922-3927)CTTGCAfs	p.L1308fs	uc001byd.3_5'Flank|uc001bye.2_5'Flank|ZMYM6_uc001byf.1_Intron|ZMYM6_uc010oht.1_Frame_Shift_Ins_p.L1211fs	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	1308_1309					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GATGTGACTGCAAGTCTTAGGG	0.366													---	---	---								A	35452759	A	A	35452758	7	5	15	1	0	1	1	0	0	0	0	0	17771	710	25	0	56	0	ZMYM6	1	35452758	Frame_Shift_Ins	INS	-	TCGA-BA-6868-01B-12D-1912-08	18177361	35452758	213797863	3	3206											
FAM159A	348378	broad.mit.edu	37	chr1	53133142	53133143	+	RNA	INS	-	CATCAC	CATCAC																															tgactgctgtggagacagatINScatcaccatcaccatcacca																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:53133142_53133143insCATCAC	uc001cug.1	+	4		c.674_675insCATCAC			FAM159A_uc001cuh.2_RNA	NM_001042693		Q6UWV7	F159A_HUMAN	hypothetical protein LOC348378							integral to membrane					0						TGGAGACAGATcatcaccatca	0.228													---	---	---								CATCAC	53133143	CATCAC	CATCAC	53133142	6	5	15	0	1	1	1	0	0	0	0	0	5496	1450	50	0		0	FAM159A	1	53133142	RNA	INS	-	TCGA-BA-6868-01B-12D-1912-08	17680384	53133142	196117479	4	3207											
DOCK7	85440	broad.mit.edu	37	chr1	63027299	63027299	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaactcacttgtgtatggaTagacgaaacagcaacaactt	17	9	7	8	1	1	1	1	0	0	1	1	3	1	2	0	1	5	2	0	1	7	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:63027299T>C	uc001daq.2	-	19	2222	c.2188A>G	c.(2188-2190)ATC>GTC	p.I730V	DOCK7_uc001dan.2_Missense_Mutation_p.I622V|DOCK7_uc001dao.2_Missense_Mutation_p.I622V|DOCK7_uc001dap.2_Missense_Mutation_p.I730V	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	730	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						TGTGTATGGATAGACGAAACA	0.294													39	66					0	0	0	0	C	63027299	C	C	63027299	3	2	15	1	0	0	0	0	1	0	0	0	4714	1406	49	5	4265	5	DOCK7	1	63027299	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	9894157	63027299	186223322	5	3208											
COL11A1	1301	broad.mit.edu	37	chr1	103474059	103474059	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcacctttggccccagatGaaccaggccccccctataga	9	8	7	17	0	1	3	1	1	1	2	2	3	1	3	7	2	1	0	7	2	3	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:103474059G>T	uc001dul.2	-	15	1961	c.1643C>A	c.(1642-1644)TCA>TAA	p.S548*	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Nonsense_Mutation_p.S560*|COL11A1_uc001dun.2_Nonsense_Mutation_p.S509*|COL11A1_uc009weh.2_Nonsense_Mutation_p.S432*	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	548	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGCCCCAGATGAACCAGGCCC	0.299													14	36					1.3612e-06	1.71976e-06	1	0	T	103474059	T	T	103474059	4	4	15	1	0	0	0	0	0	1	0	0	3682	1294	45	2	3989	2	COL11A1	1	103474059	Nonsense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	40446760	103474059	145776562	6	3209											
ATP1A1	476	broad.mit.edu	37	chr1	116927412	116927412	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttttcccttaggatgatcAtaaacttagccttgatgaac	11	15	7	8	0	1	3	1	3	0	0	2	4	2	4	2	1	3	1	2	1	5	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:116927412A>G	uc001ege.2	+	3	470	c.131A>G	c.(130-132)CAT>CGT	p.H44R	ATP1A1_uc010owv.1_Missense_Mutation_p.H13R|ATP1A1_uc001egd.2_Missense_Mutation_p.H44R|ATP1A1_uc010oww.1_Missense_Mutation_p.H44R|ATP1A1_uc010owx.1_Missense_Mutation_p.H13R	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	44	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TAGGATGATCATAAACTTAGC	0.313													22	39					0	0	0	0	G	116927412	G	G	116927412	3	3	15	1	0	0	0	0	1	0	0	0	1130	217	8	5	157	5	ATP1A1	1	116927412	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	13453353	116927412	132323209	7	3210											
SMG5	23381	broad.mit.edu	37	chr1	156243195	156243195	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcttggtagtaaaatctctcGgctagcagctcggtatctac	9	12	10	10	2	2	0	0	0	2	0	5	0	2	0	0	3	3	7	0	3	6	6	rs151161240	byFrequency	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:156243195G>A	uc001foc.3	-	6	740	c.591C>T	c.(589-591)GCC>GCT	p.A197A		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	197					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					AAAATCTCTCGGCTAGCAGCT	0.468													19	32					0	0	0	0	A	156243195	A	A	156243195	2	1	15	1	0	0	0	0	0	0	0	1	14860	1103	39	1		1	SMG5	1	156243195	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	39315783	156243195	93007426	8	3211											
GORAB	92344	broad.mit.edu	37	chr1	170508524	170508524	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagttaacgttcaaaaaccaCctttttcttcccctactctt	10	15	3	13	1	3	0	1	0	2	0	4	1	4	0	4	0	3	2	4	0	4	7			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:170508524C>A	uc001gha.2	+	2	337	c.310C>A	c.(310-312)CCT>ACT	p.P104T	GORAB_uc009wvw.2_3'UTR|GORAB_uc001ggz.3_Missense_Mutation_p.P104T|GORAB_uc009wvx.2_5'UTR|GORAB_uc001ghb.2_5'UTR|GORAB_uc001ghc.2_5'UTR	NM_152281	NP_689494	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting isoform a	104						Golgi apparatus|nucleus					0						TCAAAAACCACCTTTTTCTTC	0.473													16	43					0.000308642	0.000378854	1	0	A	170508524	A	A	170508524	3	1	15	1	0	0	0	0	1	0	0	0	6611	507	18	4	316	4	GORAB	1	170508524	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	14265329	170508524	78742097	9	3212											
C1orf129	80133	broad.mit.edu	37	chr1	170965783	170965783	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catggagtctgctttattgcTaagtaagaacaggggtctct	10	13	11	7	0	2	1	0	0	2	1	3	2	2	2	0	3	3	3	0	3	4	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:170965783T>C	uc001ghg.2	+	14	1603	c.1473T>C	c.(1471-1473)GCT>GCC	p.A491A	C1orf129_uc009wvy.2_Silent_p.A298A|C1orf129_uc010plz.1_Silent_p.A491A	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	491							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCTTTATTGCTAAGTAAGAAC	0.428													4	136					0	0	0	0	C	170965783	C	C	170965783	2	2	15	1	0	0	0	0	0	0	0	1	2005	1509	53	5		5	C1orf129	1	170965783	Silent	SNP	T	TCGA-BA-6868-01B-12D-1912-08	457259	170965783	78284838	10	3213											
STX6	10228	broad.mit.edu	37	chr1	180959168	180959168	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaatgagaattggctctctgGagctctcggtccagacgccc	9	9	11	12	2	2	2	0	1	2	2	5	4	3	3	2	3	1	2	2	3	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:180959168G>C	uc010pnq.1	-	5	678	c.441C>G	c.(439-441)CTC>CTG	p.L147L	STX6_uc001goo.2_Silent_p.L147L|STX6_uc010pnr.1_Silent_p.L46L	NM_005819	NP_005810	O43752	STX6_HUMAN	syntaxin 6	147	Cytoplasmic (Potential).				Golgi vesicle transport|intracellular protein transport|vesicle fusion	clathrin-coated vesicle|early endosome|integral to membrane|perinuclear region of cytoplasm|plasma membrane|trans-Golgi network membrane	SNAP receptor activity			ovary(1)	1						TGGCTCTCTGGAGCTCTCGGT	0.557													48	66					0	0	0	0	C	180959168	C	C	180959168	2	2	15	1	0	0	0	0	0	0	0	1	15415	1161	41	2		2	STX6	1	180959168	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	9993385	180959168	68291453	11	3214											
KLHDC8A	55220	broad.mit.edu	37	chr1	205306715	205306715	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtctccaggacagtgggttGattccctgaaagtgtcaagg	9	10	13	9	1	2	2	1	2	1	0	4	3	3	3	2	3	0	1	2	3	2	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:205306715G>A	uc001hcf.1	-	6	1433	c.865C>T	c.(865-867)CAA>TAA	p.Q289*	KLHDC8A_uc010prg.1_Nonsense_Mutation_p.Q176*|KLHDC8A_uc001hcg.1_Nonsense_Mutation_p.Q289*	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	289	Kelch 7.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACAGTGGGTTGATTCCCTGAA	0.587													45	51					0	0	0	0	A	205306715	A	A	205306715	4	1	15	1	0	0	0	0	0	1	0	0	8401	1299	45	2	191	2	KLHDC8A	1	205306715	Nonsense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	24347547	205306715	43943906	12	3215											
INTS7	25896	broad.mit.edu	37	chr1	212120048	212120048	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgcagaggcatgctgtgtgCtgggggaaaaaagaaactaa	14	8	14	5	0	0	2	0	0	0	2	0	3	0	3	0	3	4	4	0	3	5	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:212120048C>T	uc001hiw.1	-	18	2422	c.2317_splice	c.e18-1	p.H773_splice	INTS7_uc009xdb.1_Intron|INTS7_uc001hix.1_Splice_Site_p.H649_splice|INTS7_uc001hiy.1_Splice_Site_p.H759_splice|INTS7_uc010pta.1_Splice_Site_p.H724_splice	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7						snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		ATGCTGTGTGCTGGGGGAAAA	0.348													3	58					0	0	0	0	T	212120048	T	T	212120048	5	4	15	1	0	0	0	0	0	0	1	0	7822	811	28	4	584	4	INTS7	1	212120048	Splice_Site	SNP	C	TCGA-BA-6868-01B-12D-1912-08	6813333	212120048	37130573	13	3216											
SPHAR	10638	broad.mit.edu	37	chr1	229440922	229440922	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtatgtatctgttttagatAttttgagttttgcttttttt	7	25	7	2	0	1	2	0	1	1	1	1	2	1	2	0	0	1	5	0	0	4	12			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:229440922A>G	uc001htk.3	+	1	794	c.41A>G	c.(40-42)TAT>TGT	p.Y14C		NM_006542	NP_006533	Q15513	SPHAR_HUMAN	S-phase response (cyclin-related)	14					DNA replication						0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)				TGTTTTAGATATTTTGAGTTT	0.299													26	32					0	0	0	0	G	229440922	G	G	229440922	3	3	15	1	0	0	0	0	1	0	0	0	15111	449	16	5	43	5	SPHAR	1	229440922	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	17320874	229440922	19809699	14	3217											
OR2G3	81469	broad.mit.edu	37	chr1	247769130	247769130	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actagccttgctcctcagacCttagttaacttgcaaagacc	11	11	6	13	0	1	2	1	0	0	2	2	2	2	2	4	0	4	3	4	0	4	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:247769130C>G	uc010pyz.1	+	1	243	c.243C>G	c.(241-243)ACC>ACG	p.T81T		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTCCTCAGACCTTAGTTAACT	0.458													120	194					0	0	0	0	G	247769130	G	G	247769130	2	3	15	1	0	0	0	0	0	0	0	1	11053	668	24	4		4	OR2G3	1	247769130	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	18328208	247769130	1481491	15	3218											
OR2G6	391211	broad.mit.edu	37	chr1	248684984	248684984	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagctctgaaaagggatttCttctcctgggattttcagat	10	14	9	8	0	4	2	1	1	3	1	5	4	4	4	1	2	1	1	1	2	2	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:248684984C>G	uc001ien.1	+	1	37	c.37C>G	c.(37-39)CTT>GTT	p.L13V		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAAGGGATTTCTTCTCCTGGG	0.423													44	75					0	0	0	0	G	248684984	G	G	248684984	3	3	15	1	0	0	0	0	1	0	0	0	11054	913	32	2	39	2	OR2G6	1	248684984	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	915854	248684984	565637	16	3219											
SH3BP5L	80851	broad.mit.edu	37	chr1	249107242	249107242	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagtaggggcggctcttgccGatggccctccggagggtctt	5	9	16	11	3	2	0	0	0	2	0	3	2	3	1	3	6	1	2	3	6	2	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr1:249107242G>A	uc001iew.1	-	6	1209	c.657C>T	c.(655-657)ATC>ATT	p.I219I	SH3BP5L_uc010pzp.1_Silent_p.I112I|SH3BP5L_uc010pzq.1_Silent_p.I187I|SH3BP5L_uc001iev.1_Silent_p.I100I	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	219	Potential.										0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGCTCTTGCCGATGGCCCTCC	0.652													25	43					0	0	0	0	A	249107242	A	A	249107242	2	1	15	1	0	0	0	0	0	0	0	1	14313	1048	37	1		1	SH3BP5L	1	249107242	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	422258	249107242	143379	17	3220											
TTC27	55622	broad.mit.edu	37	chr2	32927945	32927945	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctccggacaaaacttgagaaAggaagtactcgccgagtgga	14	6	12	9	3	0	1	0	1	0	1	2	6	1	4	2	3	2	1	2	3	5	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:32927945A>G	uc002rom.2	+	10	1422	c.1191A>G	c.(1189-1191)AAA>AAG	p.K397K	TTC27_uc010ymx.1_Silent_p.K347K	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	397							protein binding			central_nervous_system(1)	1						AACTTGAGAAAGGAAGTACTC	0.438													50	102					0	0	0	0	G	32927945	G	G	32927945	2	3	15	1	0	0	0	0	0	0	0	1	16763	69	3	5		5	TTC27	2	32927945	Silent	SNP	A	TCGA-BA-6868-01B-12D-1912-08		32927945	210271428	18	3221											
CEBPZ	10153	broad.mit.edu	37	chr2	37455847	37455847	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaaattcaaagatgttctgTttatctttctttactttcgg	11	19	5	6	1	4	1	1	0	3	1	5	1	4	1	0	1	1	2	0	1	5	8			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:37455847T>C	uc002rpz.2	-	2	519	c.489A>G	c.(487-489)AAA>AAG	p.K163K	C2orf56_uc010ynj.1_5'Flank|C2orf56_uc002rqa.3_5'Flank|C2orf56_uc002rqc.3_5'Flank|C2orf56_uc010ynk.1_5'Flank|C2orf56_uc010ynl.1_5'Flank	NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	163					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				AGATGTTCTGTTTATCTTTCT	0.373													50	70					0	0	0	0	C	37455847	C	C	37455847	2	2	15	1	0	0	0	0	0	0	0	1	3219	1722	60	5		5	CEBPZ	2	37455847	Silent	SNP	T	TCGA-BA-6868-01B-12D-1912-08	4527902	37455847	205743526	19	3222											
ABCG8	64241	broad.mit.edu	37	chr2	44079515	44079515	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggacgtgatcgcggagcTgcggcttaggcagtgcgctg	6	7	19	9	5	0	1	0	1	0	0	1	4	0	4	0	5	3	4	0	5	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:44079515T>C	uc002rtq.2	+	5	674	c.584T>C	c.(583-585)CTG>CCG	p.L195P	ABCG8_uc010yoa.1_Missense_Mutation_p.L195P	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	195	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ATCGCGGAGCTGCGGCTTAGG	0.637													24	31					0	0	0	0	C	44079515	C	C	44079515	3	2	15	1	0	0	0	0	1	0	0	0	72	1580	55	5	602	5	ABCG8	2	44079515	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	6623668	44079515	199119858	20	3223											
ANKRD36B	57730	broad.mit.edu	37	chr2	98165918	98165918	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatcctttttttctctggCtatattcaaaacagaatctt	10	18	3	10	0	3	1	1	0	2	1	6	1	5	1	2	1	1	1	2	1	5	7			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:98165918C>G	uc010yvc.1	-	20	1721	c.1441G>C	c.(1441-1443)GCC>CCC	p.A481P	ANKRD36B_uc010yve.1_RNA	NM_025190	NP_079466	Q8N2N9	AN36B_HUMAN	ankyrin repeat domain 36B	481											0						TTTTCTCTGGCTATATTCAAA	0.303													3	36					0	0	0	0	G	98165918	G	G	98165918	3	3	15	1	0	0	0	0	1	0	0	0	666	797	28	4	2716	4	ANKRD36B	2	98165918	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	54086403	98165918	145033455	21	3224											
MRPS9	64965	broad.mit.edu	37	chr2	105696507	105696507	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tactggcaaacagtcatactAttcattaatgcatgtaagta	15	13	6	7	0	2	0	2	0	0	0	2	0	2	0	0	1	4	4	0	1	7	7			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:105696507A>T	uc002tcn.3	+	5	544	c.476A>T	c.(475-477)TAT>TTT	p.Y159F		NM_182640	NP_872578	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9 precursor	159					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						CAGTCATACTATTCATTAATG	0.333													38	60					0	0	0	0	T	105696507	T	T	105696507	3	4	15	1	0	0	0	0	1	0	0	0	9902	449	16	5	494	5	MRPS9	2	105696507	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	7530589	105696507	137502866	22	3225											
LRP1B	53353	broad.mit.edu	37	chr2	141122323	141122323	+	Frame_Shift_Del	DEL	G	-	-																															gcagagagaattattgcaaaGgaactcatcagctctacata																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:141122323delG	uc002tvj.1	-	72	12010	c.11038delC	c.(11038-11040)CTTfs	p.L3680fs		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3680	Extracellular (Potential).|LDL-receptor class A 30.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTATTGCAAAGGAACTCATCA	0.403										TSP Lung(27;0.18)			---	---	---								-	141122323	-	-	141122323	7	5	15	1	0	1	0	1	0	0	0	0	9005	1000	35	0	2841	0	LRP1B	2	141122323	Frame_Shift_Del	DEL	G	TCGA-BA-6868-01B-12D-1912-08	35425816	141122323	102077050	23	3226											
LRP1B	53353	broad.mit.edu	37	chr2	141128783	141128783	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcacaatcatattctccatTacatttcaaagatgctgaaa	16	12	4	9	0	3	2	2	1	1	1	4	2	3	2	1	0	3	2	1	0	5	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:141128783T>A	uc002tvj.1	-	70	11812	c.10840A>T	c.(10840-10842)AAT>TAT	p.N3614Y		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3614	Extracellular (Potential).|LDL-receptor class A 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATTCTCCATTACATTTCAAA	0.294										TSP Lung(27;0.18)			17	21					0	0	0	0	A	141128783	A	A	141128783	3	1	15	1	0	0	0	0	1	0	0	0	9005	1754	61	5	3047	5	LRP1B	2	141128783	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	6460	141128783	102070590	24	3227											
TANC1	85461	broad.mit.edu	37	chr2	160053172	160053172	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttgtccacagtgccctacgGggccacggtgacattctcca	7	9	10	15	2	1	1	0	1	1	0	3	1	2	1	4	3	2	0	4	3	1	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:160053172G>T	uc002uag.2	+	18	3307	c.3033G>T	c.(3031-3033)CGG>CGT	p.R1011R	TANC1_uc010zcm.1_Silent_p.R1003R|TANC1_uc010fom.1_Silent_p.R817R|TANC1_uc010fon.2_5'Flank	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1011	ANK 4.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						GTGCCCTACGGGGCCACGGTG	0.622													25	53					2.24059e-21	3.03829e-21	1	0	T	160053172	T	T	160053172	2	4	15	1	0	0	0	0	0	0	0	1	15610	1219	43	4		4	TANC1	2	160053172	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	18924389	160053172	83146201	25	3228											
WDSUB1	151525	broad.mit.edu	37	chr2	160139519	160139519	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aagtagccaagagggaaaagGagaaggcacagcagttgaca	18	3	14	6	0	0	3	0	1	0	2	0	5	0	4	1	3	2	4	1	3	6	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:160139519G>C	uc002uaj.3	-	2	211	c.62C>G	c.(61-63)TCC>TGC	p.S21C	WDSUB1_uc002uak.3_Missense_Mutation_p.S21C|WDSUB1_uc002ual.3_Missense_Mutation_p.S21C|WDSUB1_uc002uam.3_Missense_Mutation_p.S21C|WDSUB1_uc010foo.2_Missense_Mutation_p.S21C	NM_152528	NP_689741	Q8N9V3	WSDU1_HUMAN	WD repeat, sterile alpha motif and U-box domain	21	WD 1.					ubiquitin ligase complex	ubiquitin-protein ligase activity				0						GAGGGAAAAGGAGAAGGCACA	0.413													38	42					0	0	0	0	C	160139519	C	C	160139519	3	2	15	1	0	0	0	0	1	0	0	0	17409	1174	41	2	1408	2	WDSUB1	2	160139519	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	86347	160139519	83059854	26	3229											
LRP2	4036	broad.mit.edu	37	chr2	170129520	170129520	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccatcattatctgttctgTggctgaggacacagacctgc	10	11	9	11	0	3	2	1	1	2	1	3	3	3	3	2	2	2	2	2	2	2	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:170129520T>C	uc002ues.2	-	15	2246	c.2033A>G	c.(2032-2034)CAC>CGC	p.H678R	LRP2_uc010zdf.1_Missense_Mutation_p.H609R	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	678	EGF-like 3.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATCTGTTCTGTGGCTGAGGAC	0.453													57	100					0	0	0	0	C	170129520	C	C	170129520	3	2	15	1	0	0	0	0	1	0	0	0	9006	1696	59	5	12194	5	LRP2	2	170129520	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	9990001	170129520	73069853	27	3230											
FASTKD1	79675	broad.mit.edu	37	chr2	170428349	170428349	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacatcccacttgcttttctGaaagtatggctttgtttctt	7	18	6	10	0	2	1	0	1	2	0	3	1	3	1	1	1	1	4	1	1	2	7			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:170428349G>C	uc002uev.3	-	2	579	c.191C>G	c.(190-192)TCA>TGA	p.S64*	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Nonsense_Mutation_p.S50*|FASTKD1_uc002uey.2_Nonsense_Mutation_p.S50*	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	64					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						TTGCTTTTCTGAAAGTATGGC	0.378													30	46					0	0	0	0	C	170428349	C	C	170428349	4	2	15	1	0	0	0	0	0	1	0	0	5717	1294	45	2	2408	2	FASTKD1	2	170428349	Nonsense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	298829	170428349	72771024	28	3231											
COL4A4	1286	broad.mit.edu	37	chr2	227924929	227924929	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgaaccactcagcccagggGcaccttggggacctggaaat	10	6	12	13	0	1	1	1	1	0	0	1	3	1	3	4	5	2	1	4	5	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:227924929G>T	uc010zlt.1	-	27	2741	c.2087C>A	c.(2086-2088)GCC>GAC	p.A696D		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	696	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CAGCCCAGGGGCACCTTGGGG	0.428													36	88					2.09667e-21	2.85809e-21	1	0	T	227924929	T	T	227924929	3	4	15	1	0	0	0	0	1	0	0	0	3708	1203	42	4	3073	4	COL4A4	2	227924929	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	57496580	227924929	15274444	29	3232											
DIS3L2	129563	broad.mit.edu	37	chr2	233075076	233075076	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgacccatcaaccgcccgaGacctcgatgatgccctctcc	8	8	7	18	3	2	3	1	2	1	1	4	5	2	3	6	0	2	0	6	0	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr2:233075076G>T	uc010fxz.2	+	10	1441	c.1165G>T	c.(1165-1167)GAC>TAC	p.D389Y	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	389							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		AACCGCCCGAGACCTCGATGA	0.478													16	75					6.49762e-13	8.54256e-13	1	0	T	233075076	T	T	233075076	3	4	15	1	0	0	0	0	1	0	0	0	4559	942	33	2	1199	2	DIS3L2	2	233075076	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	5150147	233075076	10124297	30	3233											
OGG1	4968	broad.mit.edu	37	chr3	9798304	9798304	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccagaccaacaaggaactGggtgaggaaagtgggctgca	13	4	14	10	0	0	2	0	1	0	1	0	4	0	4	3	4	3	2	3	4	4	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:9798304G>A	uc003bsi.2	+	5	1240	c.897G>A	c.(895-897)CTG>CTA	p.L299L	OGG1_uc003bsh.2_Silent_p.L299L|OGG1_uc003bsj.2_Silent_p.L299L|OGG1_uc003bsk.2_Silent_p.L299L|OGG1_uc003bsl.2_Silent_p.L299L|OGG1_uc003bsm.2_Silent_p.L299L|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|OGG1_uc003bsp.1_Silent_p.L64L|OGG1_uc010hcm.1_Intron|OGG1_uc003bsq.1_Intron|OGG1_uc003bsr.1_Silent_p.L64L	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	299					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)					ACAAGGAACTGGGTGAGGAAA	0.582								BER_DNA_glycosylases					27	8					0	0	0	0	A	9798304	A	A	9798304	2	1	15	1	0	0	0	0	0	0	0	1	10899	1362	47	4		4	OGG1	3	9798304	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08		9798304	188224126	31	3234											
IMPDH2	3615	broad.mit.edu	37	chr3	49064207	49064207	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaatggctgccccacacagCagctgtttcttggcatcttt	7	12	8	14	0	2	0	0	0	2	0	2	0	2	0	3	2	3	5	3	2	1	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:49064207C>T	uc003cvt.2	-	7	824	c.732G>A	c.(730-732)CTG>CTA	p.L244L		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	244					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	CCCCACACAGCAGCTGTTTCT	0.517													113	40					0	0	0	0	T	49064207	T	T	49064207	2	4	15	1	0	0	0	0	0	0	0	1	7766	697	25	4		4	IMPDH2	3	49064207	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	39265903	49064207	148958223	32	3235											
EPHA6	285220	broad.mit.edu	37	chr3	97202882	97202882	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgatccctcaagaattcgtAttgagagagtcattggggca	11	12	11	7	1	2	4	2	2	0	2	4	5	3	4	1	2	0	2	1	2	3	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:97202882A>T	uc010how.1	+	10	2222	c.2179A>T	c.(2179-2181)ATT>TTT	p.I727F	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Missense_Mutation_p.I93F|EPHA6_uc003drs.3_Missense_Mutation_p.I119F|EPHA6_uc003drr.3_Missense_Mutation_p.I119F|EPHA6_uc003drt.2_Missense_Mutation_p.I119F|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	632	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						AAGAATTCGTATTGAGAGAGT	0.264													21	20					0	0	0	0	T	97202882	T	T	97202882	3	4	15	1	0	0	0	0	1	0	0	0	5195	449	16	5	2285	5	EPHA6	3	97202882	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	48138675	97202882	100819548	33	3236											
POLQ	10721	broad.mit.edu	37	chr3	121202255	121202255	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggatcttcataactttgcTccaaggagatgccacaagaa	14	10	8	9	0	2	2	1	0	1	2	3	4	3	3	2	2	3	1	2	2	5	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:121202255T>A	uc003eee.3	-	18	6077	c.5948A>T	c.(5947-5949)GAG>GTG	p.E1983V	POLQ_uc003eed.2_Missense_Mutation_p.E1155V	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1983					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		ATAACTTTGCTCCAAGGAGAT	0.303								DNA_polymerases_(catalytic_subunits)					27	30					0	0	0	0	A	121202255	A	A	121202255	3	1	15	1	0	0	0	0	1	0	0	0	12263	1551	54	5	1876	5	POLQ	3	121202255	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	23999373	121202255	76820175	34	3237											
PIK3R4	30849	broad.mit.edu	37	chr3	130452572	130452572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacagagtcattgctgaaatGcaaaagatatggagtaatac	18	9	9	5	0	1	3	1	1	0	2	1	4	1	4	0	1	4	3	0	1	7	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:130452572G>A	uc003enj.2	-	4	1851	c.1270C>T	c.(1270-1272)CAT>TAT	p.H424Y		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	424	HEAT 1.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TTGCTGAAATGCAAAAGATAT	0.413													43	45					0	0	0	0	A	130452572	A	A	130452572	3	1	15	1	0	0	0	0	1	0	0	0	11976	1319	46	4	2874	4	PIK3R4	3	130452572	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	9250317	130452572	67569858	35	3238											
PPP2R3A	5523	broad.mit.edu	37	chr3	135863925	135863925	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaacctgcctctccctctGaatttggaaacaaaagcaat	14	10	6	11	0	2	2	0	2	2	0	3	3	2	3	3	1	4	1	3	1	6	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:135863925G>C	uc003eqv.1	+	14	3935	c.3370G>C	c.(3370-3372)GAA>CAA	p.E1124Q	PPP2R3A_uc011blz.1_Missense_Mutation_p.E388Q|PPP2R3A_uc003eqw.1_Missense_Mutation_p.E503Q	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	1124					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						CTCTCCCTCTGAATTTGGAAA	0.358													3	44					0	0	0	0	C	135863925	C	C	135863925	3	2	15	1	0	0	0	0	1	0	0	0	12448	1291	45	2	3556	2	PPP2R3A	3	135863925	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	5411353	135863925	62158505	36	3239											
XRN1	54464	broad.mit.edu	37	chr3	142048418	142048418	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccatagactgaacattaTggtactcattagcactgtga	12	13	8	8	0	1	3	1	2	0	1	2	3	2	3	1	1	3	2	1	1	5	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr3:142048418T>C	uc003eus.2	-	37	4326	c.4259A>G	c.(4258-4260)CAT>CGT	p.H1420R	XRN1_uc010huu.2_Missense_Mutation_p.H887R|XRN1_uc003eut.2_Missense_Mutation_p.H1420R|XRN1_uc003euu.2_Missense_Mutation_p.H1421R	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1420					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						CTGAACATTATGGTACTCATT	0.383													26	26					0	0	0	0	C	142048418	C	C	142048418	3	2	15	1	0	0	0	0	1	0	0	0	17527	1464	51	5	885	5	XRN1	3	142048418	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	6184493	142048418	55974012	37	3240											
SPATA18	132671	broad.mit.edu	37	chr4	52943055	52943055	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggagaccgtccccaaaccGctccaagctgtccaatgtgg	10	6	10	15	2	0	1	0	0	0	1	3	2	3	1	6	2	2	2	6	2	3	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:52943055G>T	uc003gzl.2	+	7	1147	c.869G>T	c.(868-870)CGC>CTC	p.R290L	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.R258L|SPATA18_uc003gzk.1_Missense_Mutation_p.R290L	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	290	Ser-rich.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCCCCAAACCGCTCCAAGCTG	0.682													15	28					0.000566183	0.000691705	1	0	T	52943055	T	T	52943055	3	4	15	1	0	0	0	0	1	0	0	0	15069	1087	38	3	895	3	SPATA18	4	52943055	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08		52943055	138211221	38	3241											
PRDM8	56978	broad.mit.edu	37	chr4	81123531	81123531	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagctgagtcccgacggcatCgccacgggcggcggcaaagg	8	3	17	13	6	0	1	0	1	0	0	2	3	1	1	2	5	1	3	2	5	1	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:81123531C>T	uc010ijo.2	+	8	1754	c.915C>T	c.(913-915)ATC>ATT	p.I305I	PRDM8_uc003hmb.3_Silent_p.I305I|PRDM8_uc003hmc.3_Silent_p.I305I	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	305	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CCGACGGCATCGCCACGGGCG	0.607											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	5					0	0	0	0	T	81123531	T	T	81123531	2	4	15	1	0	0	0	0	0	0	0	1	12524	874	31	1		1	PRDM8	4	81123531	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	28180476	81123531	110030745	39	3242											
FGF5	2250	broad.mit.edu	37	chr4	81188009	81188009	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttcctcctcctcctcttcTtcagccacctgatcctcagc	4	13	3	21	0	4	1	2	1	2	0	9	1	9	1	8	0	2	0	8	0	0	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:81188009T>C	uc003hmd.2	+	1	268	c.31T>C	c.(31-33)TTC>CTC	p.F11L	FGF5_uc003hme.2_Missense_Mutation_p.F11L	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	11					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						CCTCCTCTTCTTCAGCCACCT	0.622													32	42					0	0	0	0	C	81188009	C	C	81188009	3	2	15	1	0	0	0	0	1	0	0	0	5887	1609	56	5	33	5	FGF5	4	81188009	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	64478	81188009	109966267	40	3243											
HNRPDL	9987	broad.mit.edu	37	chr4	83350560	83350560	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcggcggcggagcgttgtAtggagctggatttaaaatgg	9	9	17	6	4	0	0	0	0	0	0	0	3	0	3	0	6	3	3	0	6	3	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:83350560A>G	uc003hmr.2	-	1	819	c.284T>C	c.(283-285)ATA>ACA	p.I95T	ENOPH1_uc003hmv.2_5'Flank|ENOPH1_uc003hmw.2_5'Flank|ENOPH1_uc003hmx.2_5'Flank|HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.I95T	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	95					regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				GGAGCGTTGTATGGAGCTGGA	0.667													19	50					0	0	0	0	G	83350560	G	G	83350560	3	3	15	1	0	0	0	0	1	0	0	0	7315	449	16	5	1006	5	HNRPDL	4	83350560	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	2162551	83350560	107803716	41	3244											
C4orf36	132989	broad.mit.edu	37	chr4	87809368	87809368	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttccaagaaaggcaacttGatattggctaggtttgtgga	11	13	11	6	0	1	2	0	1	1	1	2	3	2	3	1	4	1	3	1	4	5	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:87809368G>C	uc003hqe.3	-	3	439	c.126C>G	c.(124-126)ATC>ATG	p.I42M		NM_144645	NP_653246	Q96KX1	CD036_HUMAN	hypothetical protein LOC132989	42											0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00141)		AAGGCAACTTGATATTGGCTA	0.378													24	29					0	0	0	0	C	87809368	C	C	87809368	3	2	15	1	0	0	0	0	1	0	0	0	2276	1280	45	2	235	2	C4orf36	4	87809368	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	4458808	87809368	103344908	42	3245											
MAML3	55534	broad.mit.edu	37	chr4	140811147	140811147	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttgctgtttctgctgcatGagtttggccctttgttgctg	2	19	12	8	0	1	1	0	1	1	0	1	1	1	1	1	1	4	8	1	1	0	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:140811147G>A	uc003ihz.1	-	2	2195	c.1443C>T	c.(1441-1443)CTC>CTT	p.L481L	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	481	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					tctgctgcATGAGTTTGGCCC	0.313													13	24					0	0	0	0	A	140811147	A	A	140811147	2	1	15	1	0	0	0	0	0	0	0	1	9260	1277	45	2		2	MAML3	4	140811147	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	53001779	140811147	50343129	43	3246											
INPP4B	8821	broad.mit.edu	37	chr4	143094803	143094803	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actttttctgaaagcatcttTaaagaattcttcaagctgtc	12	16	5	8	0	4	2	1	1	3	1	5	2	4	2	0	0	2	2	0	0	5	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:143094803T>G	uc003iix.3	-	17	1936	c.1341A>C	c.(1339-1341)TTA>TTC	p.L447F	INPP4B_uc003iiw.3_Missense_Mutation_p.L447F|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Missense_Mutation_p.L262F|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Missense_Mutation_p.L318F	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	447					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					AAAGCATCTTTAAAGAATTCT	0.388													26	60					0	0	0	0	G	143094803	G	G	143094803	3	3	15	1	0	0	0	0	1	0	0	0	7792	1751	61	5	1477	5	INPP4B	4	143094803	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	2283656	143094803	48059473	44	3247											
FBXW7	55294	broad.mit.edu	37	chr4	153247297	153247297	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgaacacagcggactgctGcaacatgacccatcaaaaca	16	6	7	12	1	1	2	1	2	0	0	1	3	1	3	1	1	6	2	1	1	4	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:153247297G>A	uc003ims.2	-	10	1654	c.1505C>T	c.(1504-1506)GCA>GTA	p.A502V	FBXW7_uc011cii.1_Missense_Mutation_p.A502V|FBXW7_uc003imt.2_Missense_Mutation_p.A502V|FBXW7_uc011cih.1_Missense_Mutation_p.A326V|FBXW7_uc003imq.2_Missense_Mutation_p.A422V|FBXW7_uc003imr.2_Missense_Mutation_p.A384V	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	502	WD 4.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GCGGACTGCTGCAACATGACC	0.468			Mis|N|D|F		colorectal|endometrial|T-ALL								41	53					0	0	0	0	A	153247297	A	A	153247297	3	1	15	1	0	0	0	0	1	0	0	0	5801	1319	46	4	630	4	FBXW7	4	153247297	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	10152494	153247297	37906979	45	3248											
STOX2	56977	broad.mit.edu	37	chr4	184931650	184931650	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgtccacaagctataaagaGgtgtgtattccagagatagt	13	11	10	7	1	0	2	0	0	0	2	3	3	2	2	2	1	1	2	2	1	6	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:184931650G>T	uc003ivz.1	+	3	3094	c.1659G>T	c.(1657-1659)GAG>GAT	p.E553D	STOX2_uc003iwa.1_Missense_Mutation_p.E242D	NM_020225	NP_064610	Q9P2F5	STOX2_HUMAN	storkhead box 2	553					embryo development|maternal placenta development						0		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		GCTATAAAGAGGTGTGTATTC	0.522													18	15					3.52763e-06	4.4138e-06	1	0	T	184931650	T	T	184931650	3	4	15	1	0	0	0	0	1	0	0	0	15386	991	35	4	1669	4	STOX2	4	184931650	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	31684353	184931650	6222626	46	3249											
TLR3	7098	broad.mit.edu	37	chr4	187004613	187004613	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttatttgaactaaagatcatCgatttaggattgaataattt	15	17	6	3	1	1	3	1	2	0	1	2	5	1	4	0	1	1	0	0	1	7	8			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:187004613C>T	uc003iyq.2	+	4	1874	c.1773C>T	c.(1771-1773)ATC>ATT	p.I591I	TLR3_uc011ckz.1_Silent_p.I314I|TLR3_uc003iyr.2_Silent_p.I314I	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	591	LRR 21.|Lumenal (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TAAAGATCATCGATTTAGGAT	0.388													30	45					0	0	0	0	T	187004613	T	T	187004613	2	4	15	1	0	0	0	0	0	0	0	1	16018	874	31	1		1	TLR3	4	187004613	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	2072963	187004613	4149663	47	3250											
TLR3	7098	broad.mit.edu	37	chr4	187006008	187006008	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	attgcaagtagcacttggatCcaaaaactctgtacattaaa	16	11	6	8	0	1	0	0	0	1	0	2	1	2	1	1	1	4	4	1	1	7	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:187006008C>G	uc003iyq.2	+	5	2797	c.2696C>G	c.(2695-2697)TCC>TGC	p.S899C	TLR3_uc011ckz.1_Missense_Mutation_p.S622C|TLR3_uc003iyr.2_Missense_Mutation_p.S622C	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	899	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		GCACTTGGATCCAAAAACTCT	0.328													26	26					0	0	0	0	G	187006008	G	G	187006008	3	3	15	1	0	0	0	0	1	0	0	0	16018	855	30	2	2710	2	TLR3	4	187006008	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	1395	187006008	4148268	48	3251											
ZFP42	132625	broad.mit.edu	37	chr4	188924382	188924382	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatagttggagagaattcgCttgagtattctgagtacatg	12	13	12	4	1	1	4	0	2	1	2	2	6	1	5	0	1	1	4	0	1	4	7			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr4:188924382C>G	uc003izg.1	+	3	666	c.421C>G	c.(421-423)CTT>GTT	p.L141V	ZFP42_uc003izh.1_Missense_Mutation_p.L141V|ZFP42_uc003izi.1_Missense_Mutation_p.L141V	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	141					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AGAGAATTCGCTTGAGTATTC	0.418													50	88					0	0	0	0	G	188924382	G	G	188924382	3	3	15	1	0	0	0	0	1	0	0	0	17717	797	28	4	423	4	ZFP42	4	188924382	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	1918374	188924382	2229894	49	3252											
ZDHHC11	79844	broad.mit.edu	37	chr5	837492	837492	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtggtacctggagaactccTttgtccatttgcacgtatgg	7	13	12	9	1	0	1	0	0	0	1	2	2	2	1	3	4	3	3	3	4	3	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:837492T>C	uc011cma.1	-	6	1272	c.888A>G	c.(886-888)AAA>AAG	p.K296K	ZDHHC11_uc003jbj.2_RNA|ZDHHC11_uc010itd.1_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	296						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			GGAGAACTCCTTTGTCCATTT	0.478													9	301					0	0	0	0	C	837492	C	C	837492	2	2	15	1	0	0	0	0	0	0	0	1	17668	1606	56	5		5	ZDHHC11	5	837492	Silent	SNP	T	TCGA-BA-6868-01B-12D-1912-08		837492	180077768	50	3253											
SLC45A2	51151	broad.mit.edu	37	chr5	33984637	33984637	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagtcaaaggggccatcatCagctagggatttatagatgt	13	10	12	6	0	3	2	3	0	0	2	3	3	3	3	1	3	1	1	1	3	4	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:33984637C>G	uc003jid.2	-	1	144	c.52G>C	c.(52-54)GAT>CAT	p.D18H	SLC45A2_uc003jie.2_Missense_Mutation_p.D18H|SLC45A2_uc003jif.3_Missense_Mutation_p.D18H|SLC45A2_uc011coe.1_Missense_Mutation_p.D18H	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	18	Cytoplasmic (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGGCCATCATCAGCTAGGGAT	0.582													18	58					0	0	0	0	G	33984637	G	G	33984637	3	3	15	1	0	0	0	0	1	0	0	0	14705	826	29	2	1583	2	SLC45A2	5	33984637	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	33147145	33984637	146930623	51	3254											
POLK	51426	broad.mit.edu	37	chr5	74865317	74865317	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtaggatcaatgagtatgctGgtaagtaaagatcaaataca	17	10	10	4	0	2	2	2	1	0	1	2	3	2	3	0	2	2	5	0	2	8	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:74865317G>T	uc003kdw.2	+	4	504	c.408G>T	c.(406-408)CTG>CTT	p.L136L	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003kdz.2_Silent_p.L136L|POLK_uc003kea.2_Silent_p.L136L|POLK_uc003keb.2_Silent_p.L136L|POLK_uc010izq.2_Silent_p.L136L|POLK_uc003kec.2_Silent_p.L46L|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Silent_p.L46L|POLK_uc003kee.2_Silent_p.L136L|POLK_uc003kef.2_Silent_p.L46L	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	136	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TGAGTATGCTGGTAAGTAAAG	0.328								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					16	11					1.33834e-09	1.72452e-09	1	0	T	74865317	T	T	74865317	2	4	15	1	0	0	0	0	0	0	0	1	12259	1362	47	4		4	POLK	5	74865317	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	40880680	74865317	106049943	52	3255											
CMYA5	202333	broad.mit.edu	37	chr5	79033128	79033128	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attgactccagaaaggcataCagttcatactattcagacat	15	11	6	9	0	2	3	2	1	0	2	3	3	3	3	1	1	2	2	1	1	4	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:79033128C>G	uc003kgc.2	+	2	8612	c.8540C>G	c.(8539-8541)ACA>AGA	p.T2847R		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2847						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAAAGGCATACAGTTCATACT	0.423													41	25					0	0	0	0	G	79033128	G	G	79033128	3	3	15	1	0	0	0	0	1	0	0	0	3605	478	17	4	8546	4	CMYA5	5	79033128	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	4167811	79033128	101882132	53	3256											
RGMB	285704	broad.mit.edu	37	chr5	98129212	98129212	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactggagactgccaacactCaatgccatgagaagatgcca	14	6	9	12	0	1	3	1	1	0	3	1	5	1	3	3	1	4	0	3	1	3	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:98129212C>G	uc003knc.2	+	5	1594	c.1192C>G	c.(1192-1194)CAA>GAA	p.Q398E		NM_001012761	NP_001012779	Q6NW40	RGMB_HUMAN	RGM domain family, member B	357					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding				0		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		TGCCAACACTCAATGCCATGA	0.587													9	11					0	0	0	0	G	98129212	G	G	98129212	3	3	15	1	0	0	0	0	1	0	0	0	13346	827	29	2	1206	2	RGMB	5	98129212	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	19096084	98129212	82786048	54	3257											
SHROOM1	134549	broad.mit.edu	37	chr5	132161695	132161695	+	Frame_Shift_Del	DEL	G	-	-																															tctgtccccggcgactgcgtGcgcggctcggggccgccgga																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:132161695delG	uc003kxx.2	-	4	943	c.138delC	c.(136-138)CGCfs	p.R46fs	SHROOM1_uc003kxy.1_Frame_Shift_Del_p.R46fs	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	46					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCGACTGCGTGCGCGGCTCGG	0.572													---	---	---								-	132161695	-	-	132161695	7	5	15	1	0	1	0	1	0	0	0	0	14358	1306	46	0	2448	0	SHROOM1	5	132161695	Frame_Shift_Del	DEL	G	TCGA-BA-6868-01B-12D-1912-08	34032483	132161695	48753565	55	3258											
PCDHB10	56126	broad.mit.edu	37	chr5	140574507	140574507	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aattccaccttccgaaatagCtttggatttaatattcagta	13	15	5	8	1	1	0	1	0	0	0	3	2	3	1	3	1	1	2	3	1	6	9			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:140574507C>T	uc003lix.2	+	1	2556	c.2382C>T	c.(2380-2382)AGC>AGT	p.S794S		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	794	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCGAAATAGCTTTGGATTTA	0.368													17	36					0	0	0	0	T	140574507	T	T	140574507	2	4	15	1	0	0	0	0	0	0	0	1	11589	796	28	4		4	PCDHB10	5	140574507	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	8412812	140574507	40340753	56	3259											
PCDHB11	56125	broad.mit.edu	37	chr5	140580775	140580775	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcggcagtgtcagcgctacAgacagagactcaggcaccaa	13	5	11	12	2	2	2	2	0	0	2	3	3	2	2	1	2	2	3	1	2	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:140580775A>C	uc003liy.2	+	1	1428	c.1428A>C	c.(1426-1428)ACA>ACC	p.T476T	PCDHB11_uc011daj.1_Silent_p.T111T	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	476	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAGCGCTACAGACAGAGACT	0.617													41	207					0	0	0	0	C	140580775	C	C	140580775	2	2	15	1	0	0	0	0	0	0	0	1	11590	175	7	5		5	PCDHB11	5	140580775	Silent	SNP	A	TCGA-BA-6868-01B-12D-1912-08	6268	140580775	40334485	57	3260											
PCDHGA2	56113	broad.mit.edu	37	chr5	140719966	140719966	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctgtcttctcagtgacggcCcatgaccccgacagcaacga	9	8	9	15	3	3	2	1	2	3	0	4	4	3	2	3	1	2	1	3	1	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:140719966C>A	uc003ljk.1	+	1	1613	c.1428C>A	c.(1426-1428)GCC>GCA	p.A476A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.A476A	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	476	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGACGGCCCATGACCCCG	0.542													21	86					4.43304e-23	6.0749e-23	1	0	A	140719966	A	A	140719966	2	1	15	1	0	0	0	0	0	0	0	1	11608	610	22	4		4	PCDHGA2	5	140719966	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	139191	140719966	40195294	58	3261											
ARAP3	64411	broad.mit.edu	37	chr5	141059694	141059694	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggacactcctggtcccccGagggctgggctcagcccagg	5	6	14	16	1	1	0	1	0	0	0	3	2	3	1	4	5	1	2	4	5	0	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr5:141059694G>A	uc003llm.2	-	2	438	c.360C>T	c.(358-360)CTC>CTT	p.L120L	ARAP3_uc003lln.2_Silent_p.L42L|ARAP3_uc003llo.1_Silent_p.L120L	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	120	Pro-rich.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CTGGTCCCCCGAGGGCTGGGC	0.652													105	41					0	0	0	0	A	141059694	A	A	141059694	2	1	15	1	0	0	0	0	0	0	0	1	840	1045	37	1		1	ARAP3	5	141059694	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	339728	141059694	39855566	59	3262											
HFE	3077	broad.mit.edu	37	chr6	26091716	26091716	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagctggagtgggaaaggcAcaagattcgggccaggcaga	13	4	16	8	1	0	2	0	0	0	2	1	4	0	4	1	5	1	3	1	5	3	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:26091716A>G	uc003nfx.1	+	3	675	c.515A>G	c.(514-516)CAC>CGC	p.H172R	HFE_uc003nfy.1_Missense_Mutation_p.H149R|HFE_uc010jqe.1_Missense_Mutation_p.H172R|HFE_uc003nfz.1_Missense_Mutation_p.H84R|HFE_uc003ngd.1_Missense_Mutation_p.H84R|HFE_uc003nga.1_Missense_Mutation_p.H172R|HFE_uc003ngb.1_Intron|HFE_uc003ngc.1_Intron|HFE_uc003nge.1_Intron|HFE_uc003ngf.1_Intron	NM_000410	NP_000401	Q30201	HFE_HUMAN	hemochromatosis protein isoform 1 precursor	172	Alpha-2.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|cellular iron ion homeostasis|immune response|iron ion transport|protein complex assembly|receptor-mediated endocytosis	apical part of cell|basal part of cell|cytoplasmic vesicle|early endosome|integral to plasma membrane|MHC class I protein complex|perinuclear region of cytoplasm|recycling endosome	protein binding				0						TGGGAAAGGCACAAGATTCGG	0.597									Hemochromatosis				12	33					0	0	0	0	G	26091716	G	G	26091716	3	3	15	1	0	0	0	0	1	0	0	0	7120	159	6	5	525	5	HFE	6	26091716	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08		26091716	145023351	60	3263											
HLA-A	3105	broad.mit.edu	37	chr6	29911958	29911959	+	Frame_Shift_Ins	INS	-	GC	GC																															ccatgaggccaccctgaggtINSgctgggccctgggcttctac																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:29911958_29911959insGC	uc003nol.2	+	4	679_680	c.679_680insGC	c.(679-681)TGCfs	p.C227fs	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc010jrq.2_Frame_Shift_Ins_p.C106fs|HLA-A_uc003nok.2_Frame_Shift_Ins_p.C106fs|HLA-A_uc003non.2_Frame_Shift_Ins_p.C227fs|HLA-A_uc003noo.2_Frame_Shift_Ins_p.C227fs|HLA-A_uc010jrr.2_Frame_Shift_Ins_p.C227fs|HLA-A_uc003nom.2_Frame_Shift_Ins_p.C106fs|HLA-A_uc010klp.2_Frame_Shift_Ins_p.C199fs|HLA-A_uc011dmc.1_Frame_Shift_Ins_p.C106fs|HLA-A_uc011dmd.1_Frame_Shift_Ins_p.C106fs	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	227	Extracellular (Potential).|Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CACCCTGAGGTGCTGGGCCCTG	0.604									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			---	---	---								GC	29911959	GC	GC	29911958	7	5	15	1	0	1	1	0	0	0	0	0	7234	1696	59	0	693	0	HLA-A	6	29911958	Frame_Shift_Ins	INS	-	TCGA-BA-6868-01B-12D-1912-08	3820242	29911958	141203109	61	3264											
RGL2	5863	broad.mit.edu	37	chr6	33264552	33264552	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgtgggggaggcatagggAcctggagaacacagagagat	14	4	17	6	1	0	3	0	0	0	3	0	7	0	5	1	5	2	1	1	5	3	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:33264552A>C	uc003odv.2	-	4	375	c.242T>G	c.(241-243)GTC>GGC	p.V81G	RGL2_uc003odu.2_5'Flank|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_5'UTR|RGL2_uc011drb.1_5'UTR	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	81					Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						AGGCATAGGGACCTGGAGAAC	0.562													21	31					0	0	0	0	C	33264552	C	C	33264552	3	2	15	1	0	0	0	0	1	0	0	0	13342	289	10	5	2151	5	RGL2	6	33264552	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	3352594	33264552	137850515	62	3265											
MRPS10	55173	broad.mit.edu	37	chr6	42179587	42179587	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcataactgtccaatacagcCttatcgtgacctttcaccaa	12	12	4	13	1	2	1	2	1	0	0	4	1	3	1	4	0	3	0	4	0	5	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:42179587C>G	uc003osa.3	-	4	301	c.255G>C	c.(253-255)AAG>AAC	p.K85N	MRPS10_uc011dup.1_Missense_Mutation_p.K44N	NM_018141	NP_060611	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	85					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			CCAATACAGCCTTATCGTGAC	0.388													11	31					0	0	0	0	G	42179587	G	G	42179587	3	3	15	1	0	0	0	0	1	0	0	0	9874	680	24	4	366	4	MRPS10	6	42179587	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	8915035	42179587	128935480	63	3266											
TDRD6	221400	broad.mit.edu	37	chr6	46658086	46658086	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgaactagttgtgcaggaaAaagtgaaaagagcatctgtt	15	10	11	5	0	1	3	0	2	1	1	1	4	1	4	0	1	3	4	0	1	6	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:46658086A>G	uc003oyj.2	+	1	2221	c.2221A>G	c.(2221-2223)AAA>GAA	p.K741E	TDRD6_uc010jze.2_Missense_Mutation_p.K735E	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	741					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TGTGCAGGAAAAAGTGAAAAG	0.393													10	12					0	0	0	0	G	46658086	G	G	46658086	3	3	15	1	0	0	0	0	1	0	0	0	15800	15	1	5	2223	5	TDRD6	6	46658086	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	4478499	46658086	124456981	64	3267											
TFAP2B	7021	broad.mit.edu	37	chr6	50791426	50791426	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccagcctcgggccgccttgCcccagctctcgggccttgac	3	7	11	20	3	1	1	0	1	1	0	3	1	1	1	7	2	3	1	7	2	0	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:50791426C>A	uc003pag.2	+	2	554	c.388C>A	c.(388-390)CCC>ACC	p.P130T		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	130	Gln/Pro-rich (transactivation domain).				nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					GGCCGCCTTGCCCCAGCTCTC	0.721													7	5					0.00307968	0.00374477	1	0	A	50791426	A	A	50791426	3	1	15	1	0	0	0	0	1	0	0	0	15854	739	26	4	394	4	TFAP2B	6	50791426	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	4133340	50791426	120323641	65	3268											
LYRM2	57226	broad.mit.edu	37	chr6	90347471	90347471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgttctcacctcttcggtgGcacttttgtttcttctgaat	4	20	7	10	1	4	1	1	1	4	0	6	1	4	1	1	2	0	3	1	2	1	7			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:90347471G>A	uc003pnm.2	-	2	215	c.176C>T	c.(175-177)GCC>GTC	p.A59V	LYRM2_uc010kce.1_RNA|LYRM2_uc003png.2_RNA|LYRM2_uc010kcf.1_RNA|LYRM2_uc010kcg.2_RNA|LYRM2_uc003pnl.3_RNA	NM_020466	NP_065199	Q9NU23	LYRM2_HUMAN	LYR motif containing 2	59											0		all_cancers(76;2.76e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;3.72e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0131)		CTCTTCGGTGGCACTTTTGTT	0.363													5	221					0	0	0	0	A	90347471	A	A	90347471	3	1	15	1	0	0	0	0	1	0	0	0	9171	1203	42	4	98	4	LYRM2	6	90347471	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	39556045	90347471	80767596	66	3269											
MDN1	23195	broad.mit.edu	37	chr6	90409446	90409446	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttgttgatttttgctgcaTctgttccaaaaataaagagg	11	15	10	5	0	1	2	0	1	1	1	2	2	2	2	1	2	2	5	1	2	4	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:90409446T>A	uc003pnn.1	-	58	8987	c.8871A>T	c.(8869-8871)AGA>AGT	p.R2957S		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2957					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTTGCTGCATCTGTTCCAAA	0.408													31	38					0	0	0	0	A	90409446	A	A	90409446	3	1	15	1	0	0	0	0	1	0	0	0	9468	1449	50	5	8099	5	MDN1	6	90409446	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	61975	90409446	80705621	67	3270											
RSPH4A	345895	broad.mit.edu	37	chr6	116953560	116953560	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctactcgcagctgagaatGaagaatctgaggaagatgaa	15	9	11	6	1	2	6	0	4	2	3	3	8	2	7	0	1	2	2	0	1	6	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:116953560G>A	uc003pxe.2	+	6	2252	c.2107G>A	c.(2107-2109)GAA>AAA	p.E703K	RSPH4A_uc010kee.2_3'UTR	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	703					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						AGCTGAGAATGAAGAATCTGA	0.428									Kartagener_syndrome				13	24					0	0	0	0	A	116953560	A	A	116953560	3	1	15	1	0	0	0	0	1	0	0	0	13771	1291	45	2	2129	2	RSPH4A	6	116953560	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	26544114	116953560	54161507	68	3271											
BCLAF1	9774	broad.mit.edu	37	chr6	136597187	136597187	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctcaggtgactgagtttcTttctttactgttattctttc	5	21	7	8	0	4	2	1	2	3	0	5	2	4	2	0	1	2	3	0	1	2	7			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:136597187T>C	uc003qgx.1	-	5	1729	c.1476A>G	c.(1474-1476)AAA>AAG	p.K492K	BCLAF1_uc003qgw.1_Intron|BCLAF1_uc003qgy.1_Silent_p.K490K|BCLAF1_uc011edc.1_Intron|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.K490K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	492					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ACTGAGTTTCTTTCTTTACTG	0.378													31	201					0	0	0	0	C	136597187	C	C	136597187	2	2	15	1	0	0	0	0	0	0	0	1	1385	1606	56	5		5	BCLAF1	6	136597187	Silent	SNP	T	TCGA-BA-6868-01B-12D-1912-08	19643627	136597187	34517880	69	3272											
PLEKHG1	57480	broad.mit.edu	37	chr6	151162005	151162006	+	Frame_Shift_Del	DEL	GT	-	-																															tctctaagggaaaaatttcaGtgtctcagttcaagcagctt																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:151162005_151162006delGT	uc003qny.1	+	17	4443_4444	c.4131_4132delGT	c.(4129-4134)CAGTGTfs	p.Q1377fs	PLEKHG1_uc011eem.1_Frame_Shift_Del_p.Q1436fs	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	1377_1378					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		AAAAATTTCAGTGTCTCAGTTC	0.366													---	---	---								-	151162006	-	-	151162005	7	5	15	1	0	1	0	1	0	0	0	0	12123	1020	36	0	4189	0	PLEKHG1	6	151162005	Frame_Shift_Del	DEL	GT	TCGA-BA-6868-01B-12D-1912-08	14564818	151162005	19953062	70	3273											
ARID1B	57492	broad.mit.edu	37	chr6	157522507	157522507	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccacatcccaggtcacCgggccaccaccccaaccacc	9	3	6	23	1	1	0	1	0	0	0	3	0	3	0	10	2	1	0	10	2	1	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr6:157522507C>T	uc003qqn.2	+	18	4877	c.4725C>T	c.(4723-4725)ACC>ACT	p.T1575T	ARID1B_uc003qqo.2_Silent_p.T1535T|ARID1B_uc003qqp.2_Silent_p.T1522T	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1580	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCCAGGTCACCGGGCCACCAC	0.547													45	130					0	0	0	0	T	157522507	T	T	157522507	2	4	15	1	0	0	0	0	0	0	0	1	914	639	23	1		1	ARID1B	6	157522507	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	6360502	157522507	13592560	71	3274											
CDK13	8621	broad.mit.edu	37	chr7	40027286	40027286	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gattgtctagatccagaagtCgtcattctagtatttctcct	9	16	7	9	1	4	2	1	0	3	2	7	3	5	2	2	0	0	1	2	0	4	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:40027286C>T	uc003thh.3	+	2	1582	c.1300C>T	c.(1300-1302)CGT>TGT	p.R434C	CDK13_uc003thi.3_Missense_Mutation_p.R434C|CDK13_uc011kbf.1_5'UTR	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	434					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						ATCCAGAAGTCGTCATTCTAG	0.378													25	33					0	0	0	0	T	40027286	T	T	40027286	3	4	15	1	0	0	0	0	1	0	0	0	3144	884	31	1	1306	1	CDK13	7	40027286	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08		40027286	119111377	72	3275											
STEAP2	261729	broad.mit.edu	37	chr7	89859238	89859238	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagaagtttggagaattgAaatgtatatctcctttggca	13	13	11	4	0	1	3	0	1	1	2	2	5	1	4	1	3	0	3	1	3	6	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:89859238A>G	uc003ujz.2	+	4	1466	c.1073A>G	c.(1072-1074)GAA>GGA	p.E358G	STEAP2_uc010len.2_Missense_Mutation_p.E358G|STEAP2_uc003uka.2_Missense_Mutation_p.E358G|STEAP2_uc003ukb.2_Missense_Mutation_p.E358G|STEAP2_uc003ukc.2_Missense_Mutation_p.E358G|STEAP2_uc003ukd.2_Missense_Mutation_p.E358G	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	358	Ferric oxidoreductase.				electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					TGGAGAATTGAAATGTATATC	0.373													3	126					0	0	0	0	G	89859238	G	G	89859238	3	3	15	1	0	0	0	0	1	0	0	0	15344	246	9	5	1083	5	STEAP2	7	89859238	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	49831952	89859238	69279425	73	3276											
ZAN	7455	broad.mit.edu	37	chr7	100348484	100348484	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttactggcagaacacctccGtcaccgtcccctcaggacac	9	7	7	18	2	2	1	2	0	0	1	4	2	4	2	5	2	2	1	5	2	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:100348484G>A	uc003uwj.2	+	12	1651	c.1486G>A	c.(1486-1488)GTC>ATC	p.V496I	ZAN_uc003uwk.2_Missense_Mutation_p.V496I|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	496	MAM 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GAACACCTCCGTCACCGTCCC	0.632													13	64					0	0	0	0	A	100348484	A	A	100348484	3	1	15	1	0	0	0	0	1	0	0	0	17581	1145	40	1	1528	1	ZAN	7	100348484	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	10489246	100348484	58790179	74	3277											
TRYX3	136541	broad.mit.edu	37	chr7	141955074	141955074	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctcatagccaatcacttgCagatgcttttcattagagtc	10	15	6	10	0	3	2	3	0	1	2	5	2	3	2	1	0	3	2	1	0	3	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:141955074C>A	uc003vxb.2	-	3	557	c.237G>T	c.(235-237)CTG>CTT	p.L79L	TRYX3_uc003vxc.3_Silent_p.L79L	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	79	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					CAATCACTTGCAGATGCTTTT	0.413													36	16					3.76114e-14	4.99556e-14	1	0	A	141955074	A	A	141955074	2	1	15	1	0	0	0	0	0	0	0	1	16671	697	25	4		4	TRYX3	7	141955074	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	41606590	141955074	17183589	75	3278											
MLL3	58508	broad.mit.edu	37	chr7	151921619	151921619	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catcacacagcaggagtcttCctgggtcagttgccttccca	8	10	9	14	0	3	0	2	0	1	0	5	1	5	1	3	2	2	2	3	2	0	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr7:151921619C>A	uc003wla.2	-	19	3278	c.3059G>T	c.(3058-3060)GGA>GTA	p.G1020V	MLL3_uc003wkz.2_Missense_Mutation_p.G81V	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1020	PHD-type 5.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CAGGAGTCTTCCTGGGTCAGT	0.488			N		medulloblastoma								13	13					0.00400662	0.00484914	1	0	A	151921619	A	A	151921619	3	1	15	1	0	0	0	0	1	0	0	0	9675	855	30	2	11840	2	MLL3	7	151921619	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	9966545	151921619	7217044	76	3279											
PRKDC	5591	broad.mit.edu	37	chr8	48697813	48697813	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaatgtcgttgaagtcactGagcttcattctcagtagttt	9	16	9	7	1	3	2	3	2	1	0	5	2	3	2	0	0	1	5	0	0	3	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:48697813G>A	uc003xqi.2	-	78	11025	c.10968C>T	c.(10966-10968)CTC>CTT	p.L3656L	PRKDC_uc003xqj.2_Silent_p.L3656L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3656					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGAAGTCACTGAGCTTCATTC	0.363								NHEJ					12	33					0	0	0	0	A	48697813	A	A	48697813	2	1	15	1	0	0	0	0	0	0	0	1	12583	1277	45	2		2	PRKDC	8	48697813	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08		48697813	97666209	77	3280											
KCNB2	9312	broad.mit.edu	37	chr8	73480238	73480238	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagaacgagtatttctttgAtcggcatccaggagccttca	10	11	10	10	3	2	2	1	1	1	1	4	5	3	3	2	2	2	2	2	2	2	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:73480238A>G	uc003xzb.2	+	2	857	c.269A>G	c.(268-270)GAT>GGT	p.D90G		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	90	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TATTTCTTTGATCGGCATCCA	0.493													33	91					0	0	0	0	G	73480238	G	G	73480238	3	3	15	1	0	0	0	0	1	0	0	0	8052	333	12	5	271	5	KCNB2	8	73480238	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	24782425	73480238	72883784	78	3281											
JPH1	56704	broad.mit.edu	37	chr8	75233253	75233253	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggaccccgtagcgccccttGaaaccatgtgaccactcccc	8	6	8	19	3	0	2	0	2	0	0	1	3	1	3	8	1	2	1	8	1	2	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:75233253G>C	uc003yae.2	-	1	310	c.270C>G	c.(268-270)TTC>TTG	p.F90L	JPH1_uc003yaf.2_Missense_Mutation_p.F90L|JPH1_uc003yag.1_Intron	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	90	Gly-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			AGCGCCCCTTGAAACCATGTG	0.667													9	52					0	0	0	0	C	75233253	C	C	75233253	3	2	15	1	0	0	0	0	1	0	0	0	7999	1281	45	2	1735	2	JPH1	8	75233253	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	1753015	75233253	71130769	79	3282											
ZFHX4	79776	broad.mit.edu	37	chr8	77764911	77764911	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttattggaaaactttggtttTgaactggtcattcagtataa	12	17	8	4	0	2	1	2	1	0	0	2	2	2	2	0	3	2	2	0	3	6	8			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:77764911T>C	uc003yav.2	+	10	6006	c.5619T>C	c.(5617-5619)TTT>TTC	p.F1873F	ZFHX4_uc003yau.1_Silent_p.F1918F|ZFHX4_uc003yaw.1_Silent_p.F1873F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1873						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTTTGGTTTTGAACTGGTCA	0.448										HNSCC(33;0.089)			13	47					0	0	0	0	C	77764911	C	C	77764911	2	2	15	1	0	0	0	0	0	0	0	1	17702	1809	63	5		5	ZFHX4	8	77764911	Silent	SNP	T	TCGA-BA-6868-01B-12D-1912-08	2531658	77764911	68599111	80	3283											
WWP1	11059	broad.mit.edu	37	chr8	87414410	87414410	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagctccaaaaccactcgcAtctgagcctgccgatgacac	11	6	7	17	2	1	2	0	2	1	0	3	3	2	2	5	0	4	2	5	0	2	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:87414410A>G	uc003ydt.2	+	8	982	c.702A>G	c.(700-702)GCA>GCG	p.A234A	WWP1_uc010mai.2_Intron	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	234					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						AACCACTCGCATCTGAGCCTG	0.448													15	27					0	0	0	0	G	87414410	G	G	87414410	2	3	15	1	0	0	0	0	0	0	0	1	17483	204	8	5		5	WWP1	8	87414410	Silent	SNP	A	TCGA-BA-6868-01B-12D-1912-08	9649499	87414410	58949612	81	3284											
RUNX1T1	862	broad.mit.edu	37	chr8	92983007	92983007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatcatgtcgtgggctttcCgctccgcctcagacacggcc	5	10	11	15	4	2	2	2	1	0	1	5	2	4	2	4	2	0	2	4	2	0	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:92983007C>T	uc003yfd.2	-	10	1502	c.1418G>A	c.(1417-1419)CGG>CAG	p.R473Q	RUNX1T1_uc003yfc.1_Missense_Mutation_p.R446Q|RUNX1T1_uc003yfe.1_Missense_Mutation_p.R436Q|RUNX1T1_uc010mao.2_Missense_Mutation_p.R446Q|RUNX1T1_uc011lgi.1_Missense_Mutation_p.R484Q|RUNX1T1_uc010man.1_Missense_Mutation_p.R98Q|RUNX1T1_uc003yfb.1_Missense_Mutation_p.R436Q	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	473					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GTGGGCTTTCCGCTCCGCCTC	0.617													27	29					0	0	0	0	T	92983007	T	T	92983007	3	4	15	1	0	0	0	0	1	0	0	0	13812	652	23	1	404	1	RUNX1T1	8	92983007	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	5568597	92983007	53381015	82	3285											
PKHD1L1	93035	broad.mit.edu	37	chr8	110416786	110416786	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttactctattttccagataCtatattgaaatcttgctgca	11	17	5	8	0	2	2	0	1	2	1	3	2	3	2	1	0	4	3	1	0	6	9			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:110416786C>G	uc003yne.2	+	15	1481	c.1377C>G	c.(1375-1377)TAC>TAG	p.Y459*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	459	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTCCAGATACTATATTGAAA	0.299										HNSCC(38;0.096)			9	16					0	0	0	0	G	110416786	G	G	110416786	4	3	15	1	0	0	0	0	0	1	0	0	12027	576	20	4	1435	4	PKHD1L1	8	110416786	Nonsense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	17433779	110416786	35947236	83	3286											
ENPP2	5168	broad.mit.edu	37	chr8	120596204	120596204	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acagttctgccatcatacctGcatgctgttgaccttgttat	8	15	7	11	0	2	1	1	1	1	0	2	1	2	1	3	0	4	5	3	0	2	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:120596204G>A	uc003yot.1	-	16	1539	c.1453C>T	c.(1453-1455)CAG>TAG	p.Q485*	ENPP2_uc011lic.1_Nonsense_Mutation_p.Q2*|ENPP2_uc003yor.1_Nonsense_Mutation_p.Q124*|ENPP2_uc003yos.1_Nonsense_Mutation_p.Q537*|ENPP2_uc010mdd.1_Nonsense_Mutation_p.Q485*	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	485					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CATCATACCTGCATGCTGTTG	0.363													81	249					0	0	0	0	A	120596204	A	A	120596204	4	1	15	1	0	0	0	0	0	1	0	0	5154	1328	46	4	1257	4	ENPP2	8	120596204	Nonsense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	10179418	120596204	25767818	84	3287											
FAM135B	51059	broad.mit.edu	37	chr8	139160898	139160898	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatccttcaatcttcagttCttttttaaatttttctttgg	9	22	3	7	0	5	0	2	0	3	0	6	0	6	0	1	1	0	1	1	1	4	9			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:139160898C>G	uc003yuy.2	-	14	3484	c.3313G>C	c.(3313-3315)GAA>CAA	p.E1105Q	FAM135B_uc003yux.2_Missense_Mutation_p.E1006Q|FAM135B_uc003yuz.2_Intron|FAM135B_uc003yva.2_Missense_Mutation_p.E667Q|FAM135B_uc003yvb.2_Intron	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1105										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATCTTCAGTTCTTTTTTAAAT	0.368										HNSCC(54;0.14)			10	55					0	0	0	0	G	139160898	G	G	139160898	3	3	15	1	0	0	0	0	1	0	0	0	5477	922	32	2	935	2	FAM135B	8	139160898	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	18564694	139160898	7203124	85	3288											
NAPRT1	93100	broad.mit.edu	37	chr8	144658617	144658617	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcactgggctgcagcagctCggaagaccttgcggatctcc	7	8	12	14	2	2	1	1	0	1	1	4	3	2	3	2	3	4	4	2	3	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:144658617C>T	uc003yym.3	-	7	1032	c.1007G>A	c.(1006-1008)CGA>CAA	p.R336Q	NAPRT1_uc003yyn.3_Missense_Mutation_p.R336Q|NAPRT1_uc011lkh.1_Missense_Mutation_p.R336Q|NAPRT1_uc003yyo.3_Missense_Mutation_p.R336Q	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	336					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TGCAGCAGCTCGGAAGACCTT	0.652													18	40					0	0	0	0	T	144658617	T	T	144658617	3	4	15	1	0	0	0	0	1	0	0	0	10218	884	31	1	637	1	NAPRT1	8	144658617	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	5497719	144658617	1705405	86	3289											
KIFC2	90990	broad.mit.edu	37	chr8	145698668	145698668	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaccgacactccgctcaccGggaccccctgcacccctacg	7	4	8	22	4	1	0	1	0	0	0	2	2	2	1	7	1	2	3	7	1	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr8:145698668G>T	uc003zcz.2	+	17	2417	c.2352G>T	c.(2350-2352)CCG>CCT	p.P784P	KIFC2_uc003zda.2_Silent_p.P172P	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	784	Pro-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TCCGCTCACCGGGACCCCCTG	0.741													7	16					0.000157383	0.000194106	1	0	T	145698668	T	T	145698668	2	4	15	1	0	0	0	0	0	0	0	1	8352	1103	39	3		3	KIFC2	8	145698668	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	1040051	145698668	665354	87	3290											
KIAA1432	57589	broad.mit.edu	37	chr9	5774097	5774097	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacagactagcccccgggcaGaggagagcaggggctcctcc	10	3	14	14	1	0	3	0	0	0	3	2	4	2	3	4	4	3	3	4	4	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:5774097G>A	uc003zji.2	+	25	3979	c.3886G>A	c.(3886-3888)GAG>AAG	p.E1296K	KIAA1432_uc003zjl.3_Missense_Mutation_p.E1259K|ERMP1_uc011lme.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1375						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CCCCCGGGCAGAGGAGAGCAG	0.557													19	19					0	0	0	0	A	5774097	A	A	5774097	3	1	15	1	0	0	0	0	1	0	0	0	8272	943	33	2	4058	2	KIAA1432	9	5774097	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08		5774097	135439334	88	3291											
DENND1A	57706	broad.mit.edu	37	chr9	126414381	126414381	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgttaacatccacagccaCaaaatattctgtcagatttc	13	13	5	10	0	2	1	1	0	1	1	4	1	3	1	2	0	2	2	2	0	4	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:126414381C>G	uc004bnz.1	-	9	762	c.529G>C	c.(529-531)GTG>CTG	p.V177L	DENND1A_uc011lzl.1_5'UTR|DENND1A_uc004bny.1_5'UTR|DENND1A_uc011lzm.1_Missense_Mutation_p.V145L|DENND1A_uc004boa.1_Missense_Mutation_p.V177L|DENND1A_uc004bob.1_Missense_Mutation_p.V147L|DENND1A_uc004boc.2_Missense_Mutation_p.V145L	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	177	DENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						TCCACAGCCACAAAATATTCT	0.398													16	45					0	0	0	0	G	126414381	G	G	126414381	3	3	15	1	0	0	0	0	1	0	0	0	4448	478	17	4	2663	4	DENND1A	9	126414381	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	120640284	126414381	14799050	89	3292											
GTF3C4	9329	broad.mit.edu	37	chr9	135546192	135546192	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggtgagcggcctggaaccGctggcttggtccgaggacca	6	6	17	12	4	0	1	0	1	0	0	1	4	1	3	4	6	2	2	4	6	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:135546192G>A	uc010mzv.2	+	1	465	c.207G>A	c.(205-207)CCG>CCA	p.P69P	DDX31_uc004cbq.1_5'Flank|DDX31_uc010mzu.1_5'Flank|DDX31_uc004cbr.1_5'Flank|DDX31_uc004cbs.1_5'Flank|GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	69					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GCCTGGAACCGCTGGCTTGGT	0.706													4	4					0	0	0	0	A	135546192	A	A	135546192	2	1	15	1	0	0	0	0	0	0	0	1	6914	1074	38	1		1	GTF3C4	9	135546192	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	9131811	135546192	5667239	90	3293											
NOTCH1	4851	broad.mit.edu	37	chr9	139412684	139412684	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgacagggttggtgtcgCagttggagccctcgttacag	7	11	14	9	2	0	1	0	1	0	0	2	2	0	2	1	3	2	4	1	3	1	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:139412684C>T	uc004chz.2	-	7	1160	c.1160G>A	c.(1159-1161)TGC>TAC	p.C387Y		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	387	Extracellular (Potential).|EGF-like 10.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTTGGTGTCGCAGTTGGAGCC	0.672			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			9	1					0	0	0	0	T	139412684	T	T	139412684	3	4	15	1	0	0	0	0	1	0	0	0	10601	710	25	4	6619	4	NOTCH1	9	139412684	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	3866492	139412684	1800747	91	3294											
MRPL41	64975	broad.mit.edu	37	chr9	140446808	140446808	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgacggccgcgcagctctTcagcgaagccgtggcgcctg	5	6	14	16	6	2	1	1	1	1	0	2	2	2	1	4	2	3	2	4	2	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr9:140446808T>G	uc004cnh.3	+	2	405	c.275T>G	c.(274-276)TTC>TGC	p.F92C	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	92					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		GCGCAGCTCTTCAGCGAAGCC	0.622													13	29					0	0	0	0	G	140446808	G	G	140446808	3	3	15	1	0	0	0	0	1	0	0	0	9858	1783	62	5	277	5	MRPL41	9	140446808	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	1034124	140446808	766623	92	3295											
PCDH15	65217	broad.mit.edu	37	chr10	55568819	55568819	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcctcaaccatgggccttCttcttgcaagcacaatgttt	8	13	6	14	0	3	0	1	0	2	0	4	0	4	0	4	1	3	3	4	1	3	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr10:55568819C>G	uc010qhs.1	-	37	5401	c.5006G>C	c.(5005-5007)AGA>ACA	p.R1669T	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Missense_Mutation_p.R1662T|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CATGGGCCTTCTTCTTGCAAG	0.348										HNSCC(58;0.16)			11	25					0	0	0	0	G	55568819	G	G	55568819	3	3	15	1	0	0	0	0	1	0	0	0	11565	913	32	2	925	2	PCDH15	10	55568819	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08		55568819	79965928	93	3296											
LCOR	84458	broad.mit.edu	37	chr10	98714920	98714920	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgggccatctggattacaGaatcatggacaacacttaat	13	11	8	9	0	2	1	1	0	1	1	2	3	2	3	1	3	2	0	1	3	4	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr10:98714920G>C	uc001kms.1	+	8	1064	c.543G>C	c.(541-543)CAG>CAC	p.Q181H	LCOR_uc001kmr.2_Missense_Mutation_p.Q181H|C10orf12_uc009xvg.1_Intron|LCOR_uc001kmt.1_Missense_Mutation_p.Q181H|LCOR_uc001kmu.1_Missense_Mutation_p.Q181H	NM_032440	NP_115816	Q96JN0	LCOR_HUMAN	ligand dependent nuclear receptor corepressor	181						nucleus	DNA binding			ovary(3)	3		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		CTGGATTACAGAATCATGGAC	0.478													24	34					0	0	0	0	C	98714920	C	C	98714920	3	2	15	1	0	0	0	0	1	0	0	0	8729	933	33	2	553	2	LCOR	10	98714920	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	43146101	98714920	36819827	94	3297											
OR51G1	79324	broad.mit.edu	37	chr11	4945555	4945555	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctctttggaggctgctattAagaagaattgtcatagcttt	10	15	10	6	0	2	2	1	0	1	2	2	3	2	3	0	2	2	4	0	2	5	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:4945555A>C	uc010qyr.1	-	1	15	c.15T>G	c.(13-15)CTT>CTG	p.L5L		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCTGCTATTAAGAAGAATTG	0.438													31	12					0	0	0	0	C	4945555	C	C	4945555	2	2	15	1	0	0	0	0	0	0	0	1	11152	349	13	5		5	OR51G1	11	4945555	Silent	SNP	A	TCGA-BA-6868-01B-12D-1912-08		4945555	130060961	95	3298											
HPX	3263	broad.mit.edu	37	chr11	6453230	6453230	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccatcccggctggtgtccaGacgccagtagtgggtccctg	5	8	14	14	2	0	1	0	0	0	1	3	1	3	1	5	3	0	2	5	3	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:6453230G>C	uc001mdg.2	-	8	914	c.853C>G	c.(853-855)CTG>GTG	p.L285V	HPX_uc001mdf.2_Missense_Mutation_p.L31V|HPX_uc009yfc.2_RNA	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	285	Hemopexin-like 4.				cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		CTGGTGTCCAGACGCCAGTAG	0.567													66	31					0	0	0	0	C	6453230	C	C	6453230	3	2	15	1	0	0	0	0	1	0	0	0	7385	933	33	2	547	2	HPX	11	6453230	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	1507675	6453230	128553286	96	3299											
GTF2H1	2965	broad.mit.edu	37	chr11	18369136	18369136	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatctattatttctcacaggGctatggcatttcctctgtgc	8	16	7	10	0	3	0	1	0	3	0	5	0	4	0	1	2	1	2	1	2	4	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:18369136G>T	uc001moi.2	+	9	1533	c.839G>T	c.(838-840)GGC>GTC	p.G280V	GTF2H1_uc001moh.2_Missense_Mutation_p.G280V|GTF2H1_uc009yhm.2_Missense_Mutation_p.G164V|GTF2H1_uc001moj.2_5'UTR	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	280					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding				0						ttCTCACAGGGCTATGGCATT	0.343								NER					10	23					7.48243e-07	9.49975e-07	1	0	T	18369136	T	T	18369136	3	4	15	1	0	0	0	0	1	0	0	0	6899	1217	42	4	865	4	GTF2H1	11	18369136	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	11915906	18369136	116637380	97	3300											
LRP4	4038	broad.mit.edu	37	chr11	46900527	46900527	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggtacagctgaatccgcttgGatttggggacctaagacaca	11	9	12	9	1	0	2	0	1	0	1	1	4	1	4	2	4	2	3	2	4	3	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:46900527G>C	uc001ndn.3	-	22	3213	c.3067C>G	c.(3067-3069)CCA>GCA	p.P1023A		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1023	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		AATCCGCTTGGATTTGGGGAC	0.537													117	125					0	0	0	0	C	46900527	C	C	46900527	3	2	15	1	0	0	0	0	1	0	0	0	9009	1174	41	2	2718	2	LRP4	11	46900527	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	28531391	46900527	88105989	98	3301											
OR5W2	390148	broad.mit.edu	37	chr11	55681486	55681486	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actaactcattgacctgtgtAtctgagcgagagagtaataa	14	11	9	7	1	2	3	1	2	1	1	2	5	2	3	1	0	2	2	1	0	4	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:55681486A>T	uc010rir.1	-	1	573	c.573T>A	c.(571-573)GAT>GAA	p.D191E		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGACCTGTGTATCTGAGCGAG	0.383													10	68					0	0	0	0	T	55681486	T	T	55681486	3	4	15	1	0	0	0	0	1	0	0	0	11239	446	16	5	361	5	OR5W2	11	55681486	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	8780959	55681486	79325030	99	3302											
SMTNL1	219537	broad.mit.edu	37	chr11	57310543	57310543	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagaaggctgaggagaaagAggccaaacctgaatctgggc	14	4	15	8	0	1	5	0	2	1	3	1	6	1	5	2	4	1	2	2	4	4	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:57310543A>T	uc009ymh.1	+	2	482	c.482A>T	c.(481-483)GAG>GTG	p.E161V		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	143										ovary(1)	1						GAGGAGAAAGAGGCCAAACCT	0.532													4	18					0	0	0	0	T	57310543	T	T	57310543	3	4	15	1	0	0	0	0	1	0	0	0	14879	304	11	5	488	5	SMTNL1	11	57310543	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	1629057	57310543	77695973	100	3303											
C11orf84	144097	broad.mit.edu	37	chr11	63594564	63594564	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccacagttctgtcagaaTccagcaccactgtggcaggg	9	7	12	13	0	2	1	1	0	1	1	3	1	3	1	3	3	1	3	3	3	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:63594564T>G	uc001nxt.2	+	6	1335	c.1099T>G	c.(1099-1101)TCC>GCC	p.S367A	C11orf84_uc001nxu.1_RNA	NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	367											0						TCTGTCAGAATCCAGCACCAC	0.617													11	44					0	0	0	0	G	63594564	G	G	63594564	3	3	15	1	0	0	0	0	1	0	0	0	1673	1435	50	5	1121	5	C11orf84	11	63594564	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	6284021	63594564	71411952	101	3304											
RELA	5970	broad.mit.edu	37	chr11	65425831	65425831	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccgccgcagctgcatggaGacacgcacaggagcctgcag	9	3	15	14	3	0	1	0	0	0	1	0	3	0	2	3	3	4	5	3	3	0	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:65425831G>A	uc001ofg.2	-	8	944	c.804C>T	c.(802-804)GTC>GTT	p.V268V	RELA_uc001ofh.2_Silent_p.V265V|RELA_uc010ron.1_Silent_p.V279V|RELA_uc009yqr.2_Silent_p.V215V|RELA_uc001ofe.2_Silent_p.V268V|RELA_uc001off.2_Silent_p.V268V|RELA_uc009yqs.1_Intron	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	268	RHD.				anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4						GCTGCATGGAGACACGCACAG	0.627													25	43					0	0	0	0	A	65425831	A	A	65425831	2	1	15	1	0	0	0	0	0	0	0	1	13281	929	33	2		2	RELA	11	65425831	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	1831267	65425831	69580685	102	3305											
CATSPER1	117144	broad.mit.edu	37	chr11	65792826	65792826	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agactcctgtacgagaagcaGcagggccgggggcatcgtga	10	5	16	10	3	0	3	0	1	0	2	2	4	1	3	2	3	3	4	2	3	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:65792826G>T	uc001ogt.2	-	1	1163	c.1025C>A	c.(1024-1026)GCT>GAT	p.A342D		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	342	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						ACGAGAAGCAGCAGGGCCGGG	0.587													30	44					1.30897e-18	1.74754e-18	1	0	T	65792826	T	T	65792826	3	4	15	1	0	0	0	0	1	0	0	0	2699	971	34	4	1365	4	CATSPER1	11	65792826	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	366995	65792826	69213690	103	3306											
SHANK2	22941	broad.mit.edu	37	chr11	70333469	70333469	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctggcctctcttgttgcggaAgttggcttgcgggccggcat	3	12	15	11	3	1	0	0	0	1	0	2	1	1	1	2	5	2	4	2	5	1	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:70333469A>C	uc001oqc.2	-	21	3007	c.2929T>G	c.(2929-2931)TTC>GTC	p.F977V	SHANK2_uc010rqn.1_Missense_Mutation_p.F389V|SHANK2_uc001opz.2_Missense_Mutation_p.F382V|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	598					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTGTTGCGGAAGTTGGCTTGC	0.587													47	724					0	0	0	0	C	70333469	C	C	70333469	3	2	15	1	0	0	0	0	1	0	0	0	14330	72	3	5	2628	5	SHANK2	11	70333469	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	4540643	70333469	64673047	104	3307											
ARAP1	116985	broad.mit.edu	37	chr11	72415374	72415374	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgccattccccagctgtaaGaagagctgtgggggtgtgca	8	8	15	10	1	0	2	0	0	0	2	1	2	1	2	3	2	3	4	3	2	2	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:72415374G>C	uc001osu.2	-	14	2004	c.1815C>G	c.(1813-1815)TTC>TTG	p.F605L	ARAP1_uc001osv.2_Missense_Mutation_p.F605L|ARAP1_uc001osr.2_Missense_Mutation_p.F365L|ARAP1_uc001oss.2_Missense_Mutation_p.F360L|ARAP1_uc009yth.2_Intron|ARAP1_uc010rre.1_Missense_Mutation_p.F360L|ARAP1_uc001osw.1_5'Flank	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	605	Arf-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						CCAGCTGTAAGAAGAGCTGTG	0.667													11	56					0	0	0	0	C	72415374	C	C	72415374	3	2	15	1	0	0	0	0	1	0	0	0	838	933	33	2	2625	2	ARAP1	11	72415374	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	2081905	72415374	62591142	105	3308											
PCF11	51585	broad.mit.edu	37	chr11	82878338	82878338	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actcttgcaagcaaaagagaAttacttcaaaaggtagttac	17	10	7	7	0	2	1	1	0	1	1	2	2	2	1	0	1	4	4	0	1	9	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:82878338A>G	uc001ozx.3	+	6	2334	c.1989A>G	c.(1987-1989)GAA>GAG	p.E663E	PCF11_uc010rsu.1_Silent_p.E663E	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	663					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GCAAAAGAGAATTACTTCAAA	0.313													12	35					0	0	0	0	G	82878338	G	G	82878338	2	3	15	1	0	0	0	0	0	0	0	1	11627	98	4	5		5	PCF11	11	82878338	Silent	SNP	A	TCGA-BA-6868-01B-12D-1912-08	10462964	82878338	52128178	106	3309											
PICALM	8301	broad.mit.edu	37	chr11	85718613	85718613	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctggtatatcacctctgTcaattccaacttgctgtaag	9	14	8	10	0	4	0	2	0	2	0	5	0	5	0	2	2	2	3	2	2	5	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:85718613T>C	uc001pbm.2	-	8	1065	c.779A>G	c.(778-780)GAC>GGC	p.D260G	PICALM_uc001pbl.2_Missense_Mutation_p.D260G|PICALM_uc001pbn.2_Missense_Mutation_p.D260G|PICALM_uc010rtl.1_Missense_Mutation_p.D209G|PICALM_uc001pbo.1_5'UTR	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly	260					clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				ATCACCTCTGTCAATTCCAAC	0.289			T	MLLT10|MLL	TALL|AML|								3	96					0	0	0	0	C	85718613	C	C	85718613	3	2	15	1	0	0	0	0	1	0	0	0	11935	1667	58	5	1259	5	PICALM	11	85718613	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	2840275	85718613	49287903	107	3310											
TAF1D	79101	broad.mit.edu	37	chr11	93472441	93472441	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acagcatcagatgtcacatgGtcaagagaatctattcctga	14	10	8	9	0	4	3	3	1	1	2	5	4	5	3	1	1	1	1	1	1	3	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:93472441G>C	uc001ped.2	-	2	232	c.30C>G	c.(28-30)GAC>GAG	p.D10E	TAF1D_uc001pdz.2_RNA|TAF1D_uc001pea.1_RNA|C11orf54_uc001pee.1_5'Flank|C11orf54_uc001pef.2_5'Flank|C11orf54_uc009ywi.2_5'Flank|C11orf54_uc001peg.2_5'Flank|C11orf54_uc001peh.2_5'Flank|C11orf54_uc001pei.2_5'Flank	NM_024116	NP_077021	Q9H5J8	TAF1D_HUMAN	TATA box binding protein (TBP)-associated	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						ATGTCACATGGTCAAGAGAAT	0.308													14	69					0	0	0	0	C	93472441	C	C	93472441	3	2	15	1	0	0	0	0	1	0	0	0	15588	1252	44	4	826	4	TAF1D	11	93472441	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	7753828	93472441	41534075	108	3311											
CNTN5	53942	broad.mit.edu	37	chr11	99715973	99715973	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggggagtattcttagtagaGaagctacactgcagtttgcc	10	12	12	7	0	1	1	0	0	1	1	1	3	1	2	1	2	4	5	1	2	5	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:99715973G>C	uc001pga.2	+	6	895	c.556G>C	c.(556-558)GAA>CAA	p.E186Q	CNTN5_uc009ywv.1_Missense_Mutation_p.E186Q|CNTN5_uc001pfz.2_Missense_Mutation_p.E186Q|CNTN5_uc001pgb.2_Missense_Mutation_p.E112Q	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	186	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCTTAGTAGAGAAGCTACACT	0.338													38	362					0	0	0	0	C	99715973	C	C	99715973	3	2	15	1	0	0	0	0	1	0	0	0	3659	943	33	2	570	2	CNTN5	11	99715973	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	6243532	99715973	35290543	109	3312											
PDGFD	80310	broad.mit.edu	37	chr11	103870957	103870957	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggatggtctcatctcttcGgtacaagtctgtgaggtgat	7	14	12	8	1	3	2	1	2	3	0	6	3	3	3	0	4	1	1	0	4	2	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:103870957G>A	uc001phq.2	-	2	523	c.151C>T	c.(151-153)CGA>TGA	p.R51*	PDGFD_uc001php.2_Nonsense_Mutation_p.R45*	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	51					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TCATCTCTTCGGTACAAGTCT	0.458													25	353					0	0	0	0	A	103870957	A	A	103870957	4	1	15	1	0	0	0	0	0	1	0	0	11714	1124	39	1	985	1	PDGFD	11	103870957	Nonsense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	4154984	103870957	31135559	110	3313											
DSCAML1	57453	broad.mit.edu	37	chr11	117387378	117387378	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atggagtagtagggatagccGatgaccctgcagttgataag	12	9	14	6	1	0	2	0	2	0	0	0	5	0	4	2	2	2	4	2	2	4	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:117387378G>A	uc001prh.1	-	8	1769	c.1767C>T	c.(1765-1767)ATC>ATT	p.I589I		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	529	Extracellular (Potential).|Ig-like C2-type 6.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGGATAGCCGATGACCCTGC	0.592													7	23					0	0	0	0	A	117387378	A	A	117387378	2	1	15	1	0	0	0	0	0	0	0	1	4791	1048	37	1		1	DSCAML1	11	117387378	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	13516421	117387378	17619138	111	3314											
TECTA	7007	broad.mit.edu	37	chr11	121000847	121000847	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcagagctctgtgactcTgtggcccggtatgcaagcgc	7	9	14	11	2	3	2	1	1	2	1	3	3	3	2	1	2	3	3	1	2	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr11:121000847T>G	uc010rzo.1	+	9	2868	c.2868T>G	c.(2866-2868)TCT>TCG	p.S956S		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	956					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TCTGTGACTCTGTGGCCCGGT	0.602													21	43					0	0	0	0	G	121000847	G	G	121000847	2	3	15	1	0	0	0	0	0	0	0	1	15813	1567	55	5		5	TECTA	11	121000847	Silent	SNP	T	TCGA-BA-6868-01B-12D-1912-08	3613469	121000847	14005669	112	3315											
SOX5	6660	broad.mit.edu	37	chr12	23716248	23716248	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaacagccaccttcccatCaagcacctgttgttcccgtc	9	9	5	18	1	1	0	1	0	0	0	4	0	3	0	5	0	3	3	5	0	2	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:23716248C>G	uc001rfw.2	-	11	1534	c.1432G>C	c.(1432-1434)GAT>CAT	p.D478H	SOX5_uc001rfx.2_Missense_Mutation_p.D465H|SOX5_uc001rfy.2_Intron|SOX5_uc001rfv.2_Missense_Mutation_p.D92H|SOX5_uc010siv.1_Missense_Mutation_p.D465H|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.D430H	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	478	Potential.				transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						ACCTTCCCATCAAGCACCTGT	0.418													38	49					0	0	0	0	G	23716248	G	G	23716248	3	3	15	1	0	0	0	0	1	0	0	0	15018	826	29	2	879	2	SOX5	12	23716248	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08		23716248	110135647	113	3316											
TMEM117	84216	broad.mit.edu	37	chr12	44537363	44537363	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agactatatgggcatccgaaAtgaaagtttcatgaaattag	16	11	9	5	1	1	3	1	2	0	1	2	4	2	3	1	1	0	2	1	1	6	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:44537363A>G	uc001rod.2	+	4	512	c.446A>G	c.(445-447)AAT>AGT	p.N149S	TMEM117_uc001roe.2_Intron|TMEM117_uc009zkc.2_Missense_Mutation_p.N149S	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	149						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		GGCATCCGAAATGAAAGTTTC	0.408													20	36					0	0	0	0	G	44537363	G	G	44537363	3	3	15	1	0	0	0	0	1	0	0	0	16097	101	4	5	456	5	TMEM117	12	44537363	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	20821115	44537363	89314532	114	3317											
CCT2	10576	broad.mit.edu	37	chr12	69986801	69986801	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actctacagcaaaggttgcaGaaatagaacatgcggaaaag	18	6	10	7	1	1	2	0	0	1	2	1	3	1	3	0	2	5	3	0	2	7	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:69986801G>C	uc001svb.1	+	9	890	c.796G>C	c.(796-798)GAA>CAA	p.E266Q	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Missense_Mutation_p.E266Q|CCT2_uc010stl.1_Missense_Mutation_p.E219Q	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	266					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AAAGGTTGCAGAAATAGAACA	0.328													13	35					0	0	0	0	C	69986801	C	C	69986801	3	2	15	1	0	0	0	0	1	0	0	0	2968	943	33	2	830	2	CCT2	12	69986801	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	25449438	69986801	63865094	115	3318											
TRHDE	29953	broad.mit.edu	37	chr12	72667201	72667201	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcctctacccgcaaaccCaggtcttagtggtggtgctg	6	13	10	12	1	2	0	0	0	2	0	3	0	3	0	3	3	3	2	3	3	3	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:72667201C>A	uc001sxa.2	+	1	673	c.643C>A	c.(643-645)CAG>AAG	p.Q215K	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	215	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CCCGCAAACCCAGGTCTTAGT	0.572													28	34					1.75199e-13	2.31512e-13	1	0	A	72667201	A	A	72667201	3	1	15	1	0	0	0	0	1	0	0	0	16546	595	21	4	645	4	TRHDE	12	72667201	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	2680400	72667201	61184694	116	3319											
SLC6A15	55117	broad.mit.edu	37	chr12	85266514	85266514	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgaaaggttgatatgatggGgaataatatcctgactaatg	14	13	11	3	0	0	4	0	4	0	0	1	5	1	5	1	3	0	1	1	3	6	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:85266514G>A	uc001szv.2	-	8	1662	c.1169C>T	c.(1168-1170)CCC>CTC	p.P390L	SLC6A15_uc010sul.1_Missense_Mutation_p.P283L|SLC6A15_uc001szw.1_Missense_Mutation_p.P98L	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	390	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						GATATGATGGGGAATAATATC	0.323													3	37					0	0	0	0	A	85266514	A	A	85266514	3	1	15	1	0	0	0	0	1	0	0	0	14742	1232	43	4	1043	4	SLC6A15	12	85266514	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	12599313	85266514	48585381	117	3320											
KIAA1033	23325	broad.mit.edu	37	chr12	105556620	105556620	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttactgatgatggctttgccAtgggtaagcttaatggaatt	10	15	11	5	0	0	2	0	2	0	0	0	3	0	3	1	3	3	3	1	3	4	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:105556620A>G	uc001tld.2	+	30	3241	c.3154A>G	c.(3154-3156)ATG>GTG	p.M1052V	KIAA1033_uc010swr.1_Missense_Mutation_p.M1053V|KIAA1033_uc010sws.1_Missense_Mutation_p.M864V	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	1052					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						TGGCTTTGCCATGGGTAAGCT	0.308													4	16					0	0	0	0	G	105556620	G	G	105556620	3	3	15	1	0	0	0	0	1	0	0	0	8245	217	8	5	3272	5	KIAA1033	12	105556620	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	20290106	105556620	28295275	118	3321											
SH2B3	10019	broad.mit.edu	37	chr12	111886081	111886081	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccggagccacctgcgggccaTagacaatcagtacacacctc	11	5	9	16	2	1	1	1	0	0	1	2	2	1	2	5	2	3	1	5	2	3	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:111886081T>C	uc001tse.2	+	8	2060	c.1703T>C	c.(1702-1704)ATA>ACA	p.I568T	SH2B3_uc010syf.1_Missense_Mutation_p.I568T|SH2B3_uc001tsf.2_Missense_Mutation_p.I569T|SH2B3_uc010syg.1_Missense_Mutation_p.I366T	NM_005475	NP_005466	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	568					blood coagulation	cytosol	signal transducer activity			ovary(1)	1						CTGCGGGCCATAGACAATCAG	0.562													6	10					0	0	0	0	C	111886081	C	C	111886081	3	2	15	1	0	0	0	0	1	0	0	0	14294	1406	49	5	1729	5	SH2B3	12	111886081	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	6329461	111886081	21965814	119	3322											
TAOK3	51347	broad.mit.edu	37	chr12	118650751	118650751	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgatgttggcctttcctGaggtattttctgcaagcagt	6	16	11	8	0	1	2	0	2	1	0	2	2	2	2	2	2	3	5	2	2	2	5			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:118650751G>A	uc001twx.2	-	11	1082	c.787C>T	c.(787-789)CAG>TAG	p.Q263*	TAOK3_uc001tww.2_Nonsense_Mutation_p.Q93*|TAOK3_uc001twy.3_Nonsense_Mutation_p.Q263*	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	263	Protein kinase.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCCTTTCCTGAGGTATTTTC	0.348													17	12					0	0	0	0	A	118650751	A	A	118650751	4	1	15	1	0	0	0	0	0	1	0	0	15615	1299	45	2	1953	2	TAOK3	12	118650751	Nonsense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	6764670	118650751	15201144	120	3323											
NCOR2	9612	broad.mit.edu	37	chr12	124821412	124821412	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtccgggctggcgtggtgaGgtgcgaggttcttcgcaggg	3	9	21	8	4	1	1	0	1	1	0	3	2	2	1	1	7	1	3	1	7	0	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr12:124821412G>C	uc010tay.1	-	40	6188	c.6032C>G	c.(6031-6033)CCT>CGT	p.P2011R	NCOR2_uc010taz.1_Missense_Mutation_p.P1995R|NCOR2_uc010tax.1_Missense_Mutation_p.P122R	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2012					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGCGTGGTGAGGTGCGAGGTT	0.687													18	16					0	0	0	0	C	124821412	C	C	124821412	3	2	15	1	0	0	0	0	1	0	0	0	10290	1000	35	4	1582	4	NCOR2	12	124821412	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	6170661	124821412	9030483	121	3324											
NHLRC3	387921	broad.mit.edu	37	chr13	39621219	39621219	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataaaagaatccaagtatttGataaagacactggggagtgg	17	9	11	4	0	0	3	0	1	0	2	1	4	1	4	1	3	0	1	1	3	7	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr13:39621219G>A	uc001uxc.2	+	6	1043	c.721G>A	c.(721-723)GAT>AAT	p.D241N	NHLRC3_uc001uxd.2_Missense_Mutation_p.D174N|NHLRC3_uc001uxe.2_Missense_Mutation_p.D44N	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	241	NHL 3.					extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		CCAAGTATTTGATAAAGACAC	0.363													53	25					0	0	0	0	A	39621219	A	A	39621219	3	1	15	1	0	0	0	0	1	0	0	0	10461	1290	45	2	743	2	NHLRC3	13	39621219	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08		39621219	75548659	122	3325											
KIAA0564	23078	broad.mit.edu	37	chr13	42293870	42293870	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acactggagagaccttcagtCggaaatttctgtattaaaaa	15	11	8	7	1	2	1	1	0	1	1	3	4	2	3	1	2	0	1	1	2	5	4	rs140209374		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr13:42293870C>T	uc001uyj.2	-	26	3043	c.2973G>A	c.(2971-2973)CCG>CCA	p.P991P	KIAA0564_uc001uyk.2_Silent_p.P991P	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	991						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		GACCTTCAGTCGGAAATTTCT	0.303													28	14					0	0	0	0	T	42293870	T	T	42293870	2	4	15	1	0	0	0	0	0	0	0	1	8224	871	31	1		1	KIAA0564	13	42293870	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	2672651	42293870	72876008	123	3326											
ACIN1	22985	broad.mit.edu	37	chr14	23547373	23547373	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacttacacagtgtgatgaaTtctttctgattctggcagat	10	15	8	8	0	3	4	0	3	3	1	3	4	3	4	0	1	1	1	0	1	2	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:23547373T>C	uc001wit.3	-	8	2612	c.2284A>G	c.(2284-2286)ATT>GTT	p.I762V	ACIN1_uc001wis.3_Missense_Mutation_p.I444V|ACIN1_uc010akg.2_Missense_Mutation_p.I762V	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	762					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GTGTGATGAATTCTTTCTGAT	0.493													68	106					0	0	0	0	C	23547373	C	C	23547373	3	2	15	1	0	0	0	0	1	0	0	0	142	1493	52	5	1936	5	ACIN1	14	23547373	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08		23547373	83802167	124	3327											
NOVA1	4857	broad.mit.edu	37	chr14	26949229	26949229	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtctggggttgtagaatgCtgactggttctgtcttggcc	4	15	15	7	0	3	2	0	1	3	1	3	2	3	2	1	5	1	4	1	5	2	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:26949229C>A	uc001wpy.2	-	3	719	c.401G>T	c.(400-402)AGC>ATC	p.S134I	NOVA1_uc001wpz.2_Missense_Mutation_p.S134I|NOVA1_uc001wqa.2_Missense_Mutation_p.S12I|NOVA1_uc001wqb.2_Missense_Mutation_p.S134I	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	137					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		TTGTAGAATGCTGACTGGTTC	0.418													48	86					6.9144e-35	9.52568e-35	1	0	A	26949229	A	A	26949229	3	1	15	1	0	0	0	0	1	0	0	0	10608	797	28	4	1165	4	NOVA1	14	26949229	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	3401856	26949229	80400311	125	3328											
HEATR5A	25938	broad.mit.edu	37	chr14	31819914	31819915	+	Frame_Shift_Ins	INS	-	A	A																															tgtccaaaagctgttccaatINSataagaagcctacaatcaga																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:31819914_31819915insA	uc001wrf.3	-	11	1618_1619	c.1541_1542insT	c.(1540-1542)ATAfs	p.I514fs	HEATR5A_uc010ami.2_Frame_Shift_Ins_p.I412fs|HEATR5A_uc001wrg.1_Frame_Shift_Ins_p.I396fs|HEATR5A_uc010tpk.1_Frame_Shift_Ins_p.I807fs	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	801							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		GCTGTTCCAATATAAGAAGCCT	0.272													---	---	---								A	31819915	A	A	31819914	7	5	15	1	0	1	1	0	0	0	0	0	7070	1396	49	0	3799	0	HEATR5A	14	31819914	Frame_Shift_Ins	INS	-	TCGA-BA-6868-01B-12D-1912-08	4870685	31819914	75529626	126	3329											
SYNE2	23224	broad.mit.edu	37	chr14	64494410	64494410	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctaaaggagttaaaatctCagggaaactacctcttggag	14	10	10	7	0	2	0	1	0	2	0	3	3	2	3	1	3	3	2	1	3	6	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:64494410C>T	uc001xgm.2	+	43	6843	c.6613C>T	c.(6613-6615)CAG>TAG	p.Q2205*	SYNE2_uc001xgl.2_Nonsense_Mutation_p.Q2205*	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2205	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GTTAAAATCTCAGGGAAACTA	0.403													25	38					0	0	0	0	T	64494410	T	T	64494410	4	4	15	1	0	0	0	0	0	1	0	0	15512	827	29	2	6779	2	SYNE2	14	64494410	Nonsense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	32674496	64494410	42855130	127	3330											
AHNAK2	113146	broad.mit.edu	37	chr14	105415528	105415528	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatgtccacctgggggcccTtgaggtccactttgggcatc	5	11	13	12	0	0	2	0	2	0	0	3	2	2	2	4	4	0	1	4	4	0	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr14:105415528T>C	uc010axc.1	-	7	6380	c.6260A>G	c.(6259-6261)AAG>AGG	p.K2087R	AHNAK2_uc001ypx.2_Missense_Mutation_p.K1987R	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2087						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGGGGGCCCTTGAGGTCCAC	0.612													127	200					0	0	0	0	C	105415528	C	C	105415528	3	2	15	1	0	0	0	0	1	0	0	0	415	1609	56	5	11131	5	AHNAK2	14	105415528	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	40921118	105415528	1934012	128	3331											
TRPM1	4308	broad.mit.edu	37	chr15	31294736	31294736	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttttttagagtctgtctgTctttcatcatcttcctttga	5	22	5	9	0	7	2	2	1	5	1	8	2	8	2	1	0	0	0	1	0	1	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:31294736T>C	uc001zfm.2	-	27	4229	c.4101A>G	c.(4099-4101)AGA>AGG	p.R1367R	TRPM1_uc010azy.2_Silent_p.R1274R|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1367	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AGTCTGTCTGTCTTTCATCAT	0.378													64	66					0	0	0	0	C	31294736	C	C	31294736	2	2	15	1	0	0	0	0	0	0	0	1	16652	1664	58	5		5	TRPM1	15	31294736	Silent	SNP	T	TCGA-BA-6868-01B-12D-1912-08		31294736	71236656	129	3332											
DUOX1	53905	broad.mit.edu	37	chr15	45434285	45434285	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttggcttcggggtcaccatCgggaccctctgttgcttccc	3	13	11	14	2	2	0	1	0	1	0	5	1	3	1	3	4	1	3	3	4	0	4	rs140249290	byFrequency	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:45434285C>T	uc001zus.1	+	16	2143	c.1797C>T	c.(1795-1797)ATC>ATT	p.I599I	DUOX1_uc001zut.1_Silent_p.I599I|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	599	Helical; (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		GGGTCACCATCGGGACCCTCT	0.557													7	95					0	0	0	0	T	45434285	T	T	45434285	2	4	15	1	0	0	0	0	0	0	0	1	4822	874	31	1		1	DUOX1	15	45434285	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	14139549	45434285	57097107	130	3333											
RASL12	51285	broad.mit.edu	37	chr15	65347288	65347288	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agggtaggcgccttgcgcttGctctgggcccgggatgactt	4	10	16	11	3	1	1	0	1	1	0	1	2	1	2	2	4	2	3	2	4	1	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:65347288G>T	uc002aoi.1	-	5	965	c.750C>A	c.(748-750)AGC>AGA	p.S250R	RASL12_uc002aoj.1_Missense_Mutation_p.S231R|RASL12_uc010uir.1_Missense_Mutation_p.S239R	NM_016563	NP_057647	Q9NYN1	RASLC_HUMAN	RAS-like, family 12 protein	250					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			skin(1)	1						CCTTGCGCTTGCTCTGGGCCC	0.627											OREG0023189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	15					2.23348e-06	2.80812e-06	1	0	T	65347288	T	T	65347288	3	4	15	1	0	0	0	0	1	0	0	0	13148	1310	46	4	54	4	RASL12	15	65347288	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	19913003	65347288	37184104	131	3334											
CLK3	1198	broad.mit.edu	37	chr15	74919886	74919888	+	In_Frame_Del	DEL	GAG	-	-																															gccttgcctttcagagctgtGaggagaagtcagtgaagaac																								rs149199059		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:74919886_74919888delGAG	uc010uln.1	+	9	1824_1826	c.1363_1365delGAG	c.(1363-1365)GAGdel	p.E456del	CLK3_uc002ayg.3_In_Frame_Del_p.E308del|CLK3_uc002ayh.3_In_Frame_Del_p.E87del|CLK3_uc002ayj.3_In_Frame_Del_p.E285del|CLK3_uc002ayk.3_In_Frame_Del_p.E235del|CLK3_uc002ayl.3_In_Frame_Del_p.E141del	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	456	Protein kinase.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						TCAGAGCTGTGAGGAGAAGTCAG	0.576													---	---	---								-	74919888	-	-	74919886	7	5	15	1	0	1	0	1	0	0	0	0	3553	1291	45	0	1397	0	CLK3	15	74919886	In_Frame_Del	DEL	GAG	TCGA-BA-6868-01B-12D-1912-08	9572598	74919886	27611506	132	3335											
SH2D7	646892	broad.mit.edu	37	chr15	78390796	78390796	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catcgtggacccagaaaaccCacctgccacggcattcctca	11	6	7	17	2	1	1	1	0	0	1	3	2	2	2	5	2	2	1	5	2	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:78390796C>T	uc010blb.1	+	4	503	c.503C>T	c.(502-504)CCA>CTA	p.P168L		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	168											0						CCAGAAAACCCACCTGCCACG	0.607													15	24					0	0	0	0	T	78390796	T	T	78390796	3	4	15	1	0	0	0	0	1	0	0	0	14304	594	21	4	517	4	SH2D7	15	78390796	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	3470910	78390796	24140596	133	3336											
AEN	64782	broad.mit.edu	37	chr15	89173493	89173493	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcccacggcagcagaggaGgagccagggaggcacaggac	11	1	18	11	1	0	1	0	0	0	1	0	5	0	5	2	7	2	3	2	7	0	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr15:89173493G>T	uc002bmt.2	+	4	1097	c.946G>T	c.(946-948)GGA>TGA	p.G316*	AEN_uc010bnm.1_Intron	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	316					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						CAGCAGAGGAGGAGCCAGGGA	0.647													8	9					0.00448238	0.00539971	1	0	T	89173493	T	T	89173493	4	4	15	1	0	0	0	0	0	1	0	0	351	1001	35	4	956	4	AEN	15	89173493	Nonsense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	10782697	89173493	13357899	134	3337											
ADCY9	115	broad.mit.edu	37	chr16	4165167	4165167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttcaccgagtcgaacttggGgtcccaccagcggctggagg	7	7	15	12	3	1	0	1	0	0	0	3	3	2	1	3	5	2	2	3	5	1	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:4165167G>A	uc002cvx.2	-	2	816	c.277C>T	c.(277-279)CCC>TCC	p.P93S		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	93	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						TCGAACTTGGGGTCCCACCAG	0.706													12	42					0	0	0	0	A	4165167	A	A	4165167	3	1	15	1	0	0	0	0	1	0	0	0	301	1232	43	4	3824	4	ADCY9	16	4165167	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08		4165167	86189586	135	3338											
TFAP4	7023	broad.mit.edu	37	chr16	4308235	4308235	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcttttcctgggtgccctCgatgtgctggattgcctgga	3	14	13	11	1	0	0	0	0	0	0	2	3	1	2	3	3	4	2	3	3	0	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:4308235C>T	uc010uxg.1	-	7	1092	c.838G>A	c.(838-840)GAG>AAG	p.E280K		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	280					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						TGGGTGCCCTCGATGTGCTGG	0.657													18	30					0	0	0	0	T	4308235	T	T	4308235	3	4	15	1	0	0	0	0	1	0	0	0	15858	893	31	1	182	1	TFAP4	16	4308235	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	143068	4308235	86046518	136	3339											
GPRC5B	51704	broad.mit.edu	37	chr16	19871853	19871853	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcttcctgtgtgacttggcGgagcagttgggatctggaat	6	13	15	7	1	2	1	0	1	2	0	3	4	3	4	1	4	1	2	1	4	1	3	rs147744945		TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:19871853G>A	uc002dgt.2	-	4	1289	c.1181C>T	c.(1180-1182)CCG>CTG	p.P394L	GPRC5B_uc010vav.1_Missense_Mutation_p.P420L	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	394	Cytoplasmic (Potential).									lung(1)|breast(1)|skin(1)	3						GTGACTTGGCGGAGCAGTTGG	0.448													14	23					0	0	0	0	A	19871853	A	A	19871853	3	1	15	1	0	0	0	0	1	0	0	0	6764	1116	39	1	34	1	GPRC5B	16	19871853	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	15563618	19871853	70482900	137	3340											
TNRC6A	27327	broad.mit.edu	37	chr16	24800634	24800634	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacaagtgattctagcacaaActgtaagaatgctgttgtaa	15	12	8	6	0	1	2	0	1	1	1	1	2	1	2	0	0	4	5	0	0	7	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:24800634A>T	uc002dmm.2	+	6	785	c.671A>T	c.(670-672)AAC>ATC	p.N224I	TNRC6A_uc010bxs.2_5'UTR|TNRC6A_uc010vcc.1_5'UTR|TNRC6A_uc002dmn.2_5'UTR|TNRC6A_uc002dmo.2_5'UTR	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	224	Ser-rich.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TCTAGCACAAACTGTAAGAAT	0.448													47	62					0	0	0	0	T	24800634	T	T	24800634	3	4	15	1	0	0	0	0	1	0	0	0	16406	43	2	5	693	5	TNRC6A	16	24800634	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	4928781	24800634	65554119	138	3341											
SEZ6L2	26470	broad.mit.edu	37	chr16	29906732	29906732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaggcctggggatcccccaCcagccagcaccaggagctcc	8	3	11	19	0	0	0	0	0	0	0	2	2	2	2	8	4	3	2	8	4	0	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:29906732C>T	uc002duq.3	-	5	941	c.701G>A	c.(700-702)GGT>GAT	p.G234D	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.G164D|SEZ6L2_uc002dur.3_Missense_Mutation_p.G164D|SEZ6L2_uc002dus.3_Intron|SEZ6L2_uc010vec.1_Missense_Mutation_p.G234D|SEZ6L2_uc010ved.1_Missense_Mutation_p.G190D	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	234	CUB 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GGATCCCCCACCAGCCAGCAC	0.622													34	50					0	0	0	0	T	29906732	T	T	29906732	3	4	15	1	0	0	0	0	1	0	0	0	14209	507	18	4	2126	4	SEZ6L2	16	29906732	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	5106098	29906732	60448021	139	3342											
TMEM219	124446	broad.mit.edu	37	chr16	29979372	29979372	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgcaggacaactggtccttAtcacagccagggtgaccaca	11	7	10	13	0	1	1	1	1	0	0	2	2	2	2	3	3	3	1	3	3	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:29979372A>T	uc002duw.2	+	4	549	c.382A>T	c.(382-384)ATC>TTC	p.I128F	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TMEM219_uc002duy.2_Missense_Mutation_p.I128F|TMEM219_uc010bzk.1_Missense_Mutation_p.I128F|TMEM219_uc002duz.2_Missense_Mutation_p.I128F|TMEM219_uc010bzl.1_RNA	NM_194280	NP_919256	Q86XT9	TM219_HUMAN	transmembrane protein 219	128						integral to membrane					0						ACTGGTCCTTATCACAGCCAG	0.507													61	101					0	0	0	0	T	29979372	T	T	29979372	3	4	15	1	0	0	0	0	1	0	0	0	16208	449	16	5	392	5	TMEM219	16	29979372	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	72640	29979372	60375381	140	3343											
ABCC12	94160	broad.mit.edu	37	chr16	48138167	48138167	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaaaaactgctgcagaaagTtctctgcgtgaaacggcagc	14	8	10	9	2	1	2	0	1	1	1	2	2	1	2	0	1	6	4	0	1	5	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:48138167T>G	uc002efc.1	-	20	3132	c.2786A>C	c.(2785-2787)AAC>ACC	p.N929T	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_Intron|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	929	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				CTGCAGAAAGTTCTCTGCGTG	0.493													15	310					0	0	0	0	G	48138167	G	G	48138167	3	3	15	1	0	0	0	0	1	0	0	0	52	1725	60	5	1333	5	ABCC12	16	48138167	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	18158795	48138167	42216586	141	3344											
DHX38	9785	broad.mit.edu	37	chr16	72143370	72143370	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctggcggagctgggcccCatgttctatagcgtgaaaca	8	9	14	10	2	1	1	0	1	1	0	1	2	1	2	2	4	3	3	2	4	3	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:72143370C>T	uc002fcb.2	+	25	3793	c.3438C>T	c.(3436-3438)CCC>CCT	p.P1146P	DHX38_uc010vmp.1_Silent_p.P458P	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	1146					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				AGCTGGGCCCCATGTTCTATA	0.637													8	23					0	0	0	0	T	72143370	T	T	72143370	2	4	15	1	0	0	0	0	0	0	0	1	4533	581	21	4		4	DHX38	16	72143370	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	24005203	72143370	18211383	142	3345											
CLEC18B	497190	broad.mit.edu	37	chr16	74455117	74455117	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtggtgccaaggagggccaGgagcacagccaggagatgcc	10	3	18	10	0	0	1	0	0	0	1	0	4	0	3	4	6	4	1	4	6	1	0	rs141907838	byFrequency	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:74455117G>A	uc002fct.2	-	1	252	c.52C>T	c.(52-54)CTG>TTG	p.L18L	CLEC18B_uc002fcu.2_Silent_p.L18L|CLEC18B_uc010vmu.1_Silent_p.L18L|CLEC18B_uc010vmw.1_Silent_p.L18L	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	18						extracellular region	sugar binding				0						AGGAGGGCCAGGAGCACAGCC	0.682													24	99					0	0	0	0	A	74455117	A	A	74455117	2	1	15	1	0	0	0	0	0	0	0	1	3518	991	35	4		4	CLEC18B	16	74455117	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	2311747	74455117	15899636	143	3346											
CTU2	348180	broad.mit.edu	37	chr16	88780121	88780121	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcgggaccacaccctgaagGaggtcgctttctacaaccgc	9	7	11	14	3	1	1	0	1	1	0	2	3	1	3	3	3	3	1	3	3	3	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr16:88780121G>A	uc002flm.2	+	9	988	c.940G>A	c.(940-942)GAG>AAG	p.E314K	CTU2_uc002fln.2_Missense_Mutation_p.E314K|CTU2_uc010chz.2_Missense_Mutation_p.E385K|CTU2_uc010cia.2_Missense_Mutation_p.E227K	NM_001012759	NP_001012777	Q2VPK5	CTU2_HUMAN	cytoplasmic tRNA 2-thiolation protein 2 isoform	314					tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			skin(1)	1						CACCCTGAAGGAGGTCGCTTT	0.637													44	106					0	0	0	0	A	88780121	A	A	88780121	3	1	15	1	0	0	0	0	1	0	0	0	4065	1175	41	2	974	2	CTU2	16	88780121	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	14325004	88780121	1574632	144	3347											
TP53	7157	broad.mit.edu	37	chr17	7578268	7578268	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatttccttccactcggataAgatgctgaggaggggccaga	11	9	12	9	1	0	3	0	1	0	2	3	5	2	5	3	4	1	1	3	4	2	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:7578268A>G	uc002gim.2	-	6	775	c.581T>C	c.(580-582)CTT>CCT	p.L194P	TP53_uc002gig.1_Missense_Mutation_p.L194P|TP53_uc002gih.2_Missense_Mutation_p.L194P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.L62P|TP53_uc010cng.1_Missense_Mutation_p.L62P|TP53_uc002gii.1_Missense_Mutation_p.L62P|TP53_uc010cnh.1_Missense_Mutation_p.L194P|TP53_uc010cni.1_Missense_Mutation_p.L194P|TP53_uc002gij.2_Missense_Mutation_p.L194P|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.L101P|TP53_uc002gio.2_Missense_Mutation_p.L62P|TP53_uc010vug.1_Missense_Mutation_p.L155P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	194	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> H (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L194R(31)|p.L194F(16)|p.L194P(8)|p.0?(7)|p.L194H(5)|p.L194L(4)|p.A189_V197delAPPQHLIRV(4)|p.P191fs*53(2)|p.L194fs*15(2)|p.K164_P219del(1)|p.A189fs*53(1)|p.L194V(1)|p.L194fs*14(1)|p.P191fs*6(1)|p.I195fs*52(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.L194I(1)|p.L194fs*52(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACTCGGATAAGATGCTGAGG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	12					0	0	0	0	G	7578268	G	G	7578268	3	3	15	1	0	0	0	0	1	0	0	0	16448	72	3	5	713	5	TP53	17	7578268	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08		7578268	73616942	145	3348											
VTN	7448	broad.mit.edu	37	chr17	26696658	26696658	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggccttgagtctatcccCtcaggcttagaggcgcccac	7	9	10	15	1	3	2	2	1	1	1	4	2	4	2	4	3	0	1	4	3	2	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:26696658C>G	uc002hbc.2	-	3	548	c.399G>C	c.(397-399)GAG>GAC	p.E133D	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_5'Flank|SARM1_uc010waj.1_Intron|SARM1_uc010crl.1_5'Flank	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor	133					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	AGTCTATCCCCTCAGGCTTAG	0.622													17	21					0	0	0	0	G	26696658	G	G	26696658	3	3	15	1	0	0	0	0	1	0	0	0	17305	680	24	4	1061	4	VTN	17	26696658	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	19118390	26696658	54498552	146	3349											
KIAA0100	9703	broad.mit.edu	37	chr17	26962035	26962035	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagggcttggagaggcccaaGcacgagtcccttgatgtagt	9	8	14	10	1	0	2	0	1	0	1	1	4	1	2	2	3	1	3	2	3	2	3			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:26962035G>T	uc002hbu.2	-	16	2669	c.2570C>A	c.(2569-2571)GCT>GAT	p.A857D		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	857						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGAGGCCCAAGCACGAGTCCC	0.483													85	106					3.61627e-53	5.03556e-53	1	0	T	26962035	T	T	26962035	3	4	15	1	0	0	0	0	1	0	0	0	8193	971	34	4	4233	4	KIAA0100	17	26962035	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	265377	26962035	54233175	147	3350											
TIAF1	9220	broad.mit.edu	37	chr17	27400997	27400997	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtttaccttaaataggtcaTtgcacataacacgctgagac	13	11	8	9	1	1	1	1	1	0	1	1	2	1	1	1	2	3	3	1	2	5	6	rs115510379	by1000genomes	TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:27400997T>C	uc002hdv.1	-	1	1631	c.221A>G	c.(220-222)AAT>AGT	p.N74S	MYO18A_uc010wbc.1_3'UTR|MYO18A_uc002hds.2_3'UTR|MYO18A_uc010csa.1_3'UTR|MYO18A_uc002hdt.1_3'UTR|MYO18A_uc002hdu.1_3'UTR	NM_004740	NP_004731	O95411	TIAF1_HUMAN	TGFB1-induced anti-apoptotic factor 1	74					anti-apoptosis|apoptosis|I-kappaB kinase/NF-kappaB cascade	nucleus					0	Lung NSC(42;0.015)		Epithelial(11;1.19e-05)|all cancers(11;6.57e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000153)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			AAATAGGTCATTGCACATAAC	0.552													25	74					0	0	0	0	C	27400997	C	C	27400997	3	2	15	1	0	0	0	0	1	0	0	0	15954	1493	52	5	130	5	TIAF1	17	27400997	Missense_Mutation	SNP	T	TCGA-BA-6868-01B-12D-1912-08	438962	27400997	53794213	148	3351											
RFFL	117584	broad.mit.edu	37	chr17	33348470	33348470	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaggttgggtgaggtaggtgGaaccatgctggagtgaggct	8	9	20	4	0	0	2	0	2	0	0	0	5	0	4	1	7	2	4	1	7	2	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:33348470G>T	uc002hin.1	-	3	684	c.511C>A	c.(511-513)CCA>ACA	p.P171T	RFFL_uc002hiq.2_Intron|RFFL_uc002him.1_Missense_Mutation_p.P171T|RFFL_uc010cti.1_Missense_Mutation_p.P177T|RFFL_uc002hip.1_Missense_Mutation_p.P171T|RFFL_uc002hio.1_Missense_Mutation_p.P171T	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	171					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		GAGGTAGGTGGAACCATGCTG	0.587													13	19					2.27111e-07	2.89762e-07	1	0	T	33348470	T	T	33348470	3	4	15	1	0	0	0	0	1	0	0	0	13315	1174	41	2	600	2	RFFL	17	33348470	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	5947473	33348470	47846740	149	3352											
HEXIM1	10614	broad.mit.edu	37	chr17	43226879	43226879	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgacttcccgccgccggcaGaagtggaaccgacgcccgag	8	3	14	16	7	0	1	0	0	0	1	1	5	1	2	5	2	1	1	5	2	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:43226879G>C	uc002iig.2	+	1	2196	c.322G>C	c.(322-324)GAA>CAA	p.E108Q		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	108					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						GCCGCCGGCAGAAGTGGAACC	0.677											OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	5					0	0	0	0	C	43226879	C	C	43226879	3	2	15	1	0	0	0	0	1	0	0	0	7115	943	33	2	324	2	HEXIM1	17	43226879	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	9878409	43226879	37968331	150	3353											
PPM1D	8493	broad.mit.edu	37	chr17	58678140	58678140	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgcccgggagcacttgtgggGtttcatcaagaagcagaagg	10	8	15	8	1	2	2	2	0	0	2	2	3	2	3	1	4	3	3	1	4	3	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:58678140G>T	uc002iyt.1	+	1	587	c.365G>T	c.(364-366)GGT>GTT	p.G122V	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	122	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			CACTTGTGGGGTTTCATCAAG	0.637													7	35					1.26484e-09	1.63797e-09	1	0	T	58678140	T	T	58678140	3	4	15	1	0	0	0	0	1	0	0	0	12397	1261	44	4	367	4	PPM1D	17	58678140	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	15451261	58678140	22517070	151	3354											
BPTF	2186	broad.mit.edu	37	chr17	65905793	65905793	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagagcctgattctgaaaaaGatgaggtaaaaggttcagat	16	10	11	4	0	2	6	1	3	1	3	2	6	2	6	1	2	1	2	1	2	5	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:65905793G>A	uc002jgf.2	+	10	2969	c.2908G>A	c.(2908-2910)GAT>AAT	p.D970N	BPTF_uc002jge.2_Missense_Mutation_p.D1096N	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1096					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTCTGAAAAAGATGAGGTAAA	0.343													11	43					0	0	0	0	A	65905793	A	A	65905793	3	1	15	1	0	0	0	0	1	0	0	0	1500	942	33	2	3332	2	BPTF	17	65905793	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	7227653	65905793	15289417	152	3355											
CCDC57	284001	broad.mit.edu	37	chr17	80156247	80156247	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agttttctctccagtgtccaTtttagattttcatactgttc	7	20	5	9	0	2	1	1	0	1	1	6	1	4	1	2	0	1	2	2	0	2	8			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr17:80156247T>C	uc002kdz.1	-	4	814	c.459A>G	c.(457-459)AAA>AAG	p.K153K	CCDC57_uc002kdx.1_Silent_p.K153K	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	153	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			CCAGTGTCCATTTTAGATTTT	0.478													3	34					0	0	0	0	C	80156247	C	C	80156247	2	2	15	1	0	0	0	0	0	0	0	1	2840	1490	52	5		5	CCDC57	17	80156247	Silent	SNP	T	TCGA-BA-6868-01B-12D-1912-08	14250454	80156247	1038963	153	3356											
FHOD3	80206	broad.mit.edu	37	chr18	34298136	34298136	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttccatctcccctgatgctGagcccaatgacaaggtccca	9	9	8	15	0	1	3	0	3	1	0	4	3	3	3	5	1	2	2	5	1	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr18:34298136G>C	uc002kzt.1	+	15	2396	c.2299G>C	c.(2299-2301)GAG>CAG	p.E767Q	FHOD3_uc002kzs.1_Missense_Mutation_p.E784Q|FHOD3_uc010dmz.1_Missense_Mutation_p.E499Q|FHOD3_uc010dna.1_Missense_Mutation_p.E87Q	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	767					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CCCTGATGCTGAGCCCAATGA	0.542													41	249					0	0	0	0	C	34298136	C	C	34298136	3	2	15	1	0	0	0	0	1	0	0	0	5915	1291	45	2	2412	2	FHOD3	18	34298136	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08		34298136	43779112	154	3357											
PIK3C3	5289	broad.mit.edu	37	chr18	39629561	39629561	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctggataaccttttgctaaCaaaaacaggtaacaattaat	17	11	5	8	0	0	0	0	0	0	0	0	1	0	1	2	2	5	2	2	2	7	6			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr18:39629561C>G	uc002lap.2	+	21	2313	c.2255C>G	c.(2254-2256)ACA>AGA	p.T752R	PIK3C3_uc010xcl.1_Missense_Mutation_p.T689R|PIK3C3_uc002laq.2_Missense_Mutation_p.T237R|PIK3C3_uc002lar.1_Missense_Mutation_p.T136R	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	752	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						CTTTTGCTAACAAAAACAGGT	0.353										TSP Lung(28;0.18)			34	19					0	0	0	0	G	39629561	G	G	39629561	3	3	15	1	0	0	0	0	1	0	0	0	11967	478	17	4	2337	4	PIK3C3	18	39629561	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	5331425	39629561	38447687	155	3358											
MED16	10025	broad.mit.edu	37	chr19	885883	885883	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggagggcaggatctccgtgtCgatacggcacttctcgctca	7	9	13	12	4	3	0	1	0	2	0	6	3	3	2	1	4	1	3	1	4	1	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:885883C>T	uc002lqd.1	-	5	917	c.766G>A	c.(766-768)GAC>AAC	p.D256N	MED16_uc010drw.1_Missense_Mutation_p.D81N|MED16_uc002lqe.2_Missense_Mutation_p.D245N|MED16_uc002lqf.2_Missense_Mutation_p.D245N|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Missense_Mutation_p.D245N|MED16_uc010xfx.1_Intron|MED16_uc010xfy.1_Intron	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	256					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCTCCGTGTCGATACGGCAC	0.647													4	66					0	0	0	0	T	885883	T	T	885883	3	4	15	1	0	0	0	0	1	0	0	0	9487	884	31	1	1915	1	MED16	19	885883	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08		885883	58243100	156	3359											
ZFR2	23217	broad.mit.edu	37	chr19	3871980	3871980	+	5'Flank	DEL	A	-	-																															ggaatagagtgaggctctccAaaaaaaaaagaagaagaaga																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:3871980delA	uc002lyw.2	-						ZFR2_uc010xhx.1_5'Flank|ZFR2_uc002lyx.3_5'Flank|ZFR2_uc010xhy.1_5'Flank	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1							intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		gaggctctccaaaaaaaaaag	0.269													---	---	---								-	3871980	-	-	3871980	6	5	15	0	1	1	0	1	0	0	0	0	17727	145	5	0		0	ZFR2	19	3871980	5'Flank	DEL	A	TCGA-BA-6868-01B-12D-1912-08	2986097	3871980	55257003	157	3360											
FUT5	2527	broad.mit.edu	37	chr19	5867283	5867283	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccggcagttgctgggggActccatgctgaaccagatcc	7	8	14	12	1	0	2	0	1	0	1	2	3	2	3	4	3	4	4	4	3	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:5867283A>G	uc002mdo.3	-	2	542	c.454T>C	c.(454-456)TCC>CCC	p.S152P	FUT5_uc010duo.2_Missense_Mutation_p.S152P	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	152	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						TTGCTGGGGGACTCCATGCTG	0.627													7	30					0	0	0	0	G	5867283	G	G	5867283	3	3	15	1	0	0	0	0	1	0	0	0	6141	275	10	5	674	5	FUT5	19	5867283	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	1995303	5867283	53261700	158	3361											
RAVER1	125950	broad.mit.edu	37	chr19	10434234	10434234	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcagctgcccatcctggccGcacgccagctgccggaggaa	7	6	12	16	3	1	0	1	0	0	0	2	2	2	2	5	3	4	3	5	3	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:10434234G>A	uc002moa.2	-	4	896	c.816C>T	c.(814-816)TGC>TGT	p.C272C		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	255	RRM 3.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CATCCTGGCCGCACGCCAGCT	0.667													7	26					0	0	0	0	A	10434234	A	A	10434234	2	1	15	1	0	0	0	0	0	0	0	1	13159	1079	38	1		1	RAVER1	19	10434234	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	4566951	10434234	48694749	159	3362											
JAK3	3718	broad.mit.edu	37	chr19	17948809	17948809	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgtctttcgggcctccccatCcaccacctcatggcgacagc	6	9	8	18	2	2	0	1	0	1	0	5	1	4	0	6	2	1	0	6	2	0	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:17948809C>G	uc002nhn.3	-	12	1733	c.1633G>C	c.(1633-1635)GAT>CAT	p.D545H	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.D545H	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	545	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						GCCTCCCCATCCACCACCTCA	0.567		2	Mis		acute megakaryocytic leukemia|								67	95					0	0	0	0	G	17948809	G	G	17948809	3	3	15	1	0	0	0	0	1	0	0	0	7978	855	30	2	1793	2	JAK3	19	17948809	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	7514575	17948809	41180174	160	3363											
ZNF99	7652	broad.mit.edu	37	chr19	22942464	22942464	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatctggccaaaagtcttGtgtaaaatgagaactaataa	16	11	8	6	0	2	2	0	2	2	1	2	3	2	2	1	1	1	1	1	1	7	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:22942464G>C	uc010xrh.1	-	4	310	c.310C>G	c.(310-312)CAA>GAA	p.Q104E		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CAAAAGTCTTGTGTAAAATGA	0.279													16	17					0	0	0	0	C	22942464	C	C	22942464	3	2	15	1	0	0	0	0	1	0	0	0	18271	1386	48	4	2818	4	ZNF99	19	22942464	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	4993655	22942464	36186519	161	3364											
ZNF91	7644	broad.mit.edu	37	chr19	23544197	23544197	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttattaagggttaaggattgTctaaaagctttgccacattc	12	15	8	6	0	1	0	0	0	1	0	2	1	1	1	1	2	2	2	1	2	5	7			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:23544197T>C	uc002nre.2	-	4	1697	c.1584A>G	c.(1582-1584)AGA>AGG	p.R528R	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Silent_p.R496R	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	528	C2H2-type 14; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTAAGGATTGTCTAAAAGCTT	0.343													9	20					0	0	0	0	C	23544197	C	C	23544197	2	2	15	1	0	0	0	0	0	0	0	1	18267	1664	58	5		5	ZNF91	19	23544197	Silent	SNP	T	TCGA-BA-6868-01B-12D-1912-08	601733	23544197	35584786	162	3365											
ZNF91	7644	broad.mit.edu	37	chr19	23544264	23544264	+	Missense_Mutation	SNP	G	T	T																															tatgaattatcttatgtttaGtaagggttgaggattgccta																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:23544264G>T	uc002nre.2	-	4	1630	c.1517C>A	c.(1516-1518)ACT>AAT	p.T506N	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.T474N	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	506	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				CTTATGTTTAGTAAGGGTTGA	0.363													9	31					5.4927e-09	7.04262e-09	1	0	T	23544264	T	T	23544264	3	4	15	1	0	0	0	0	1	0	0	0	18267	1029	36	4	2062	4	ZNF91	19	23544264	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	67	23544264	35584719	163	3366	8	2									
ZNF91	7644	broad.mit.edu	37	chr19	23544273	23544273	+	Missense_Mutation	SNP	G	A	A																															tcttatgtttagtaagggttGaggattgcctaaaagctttg																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:23544273G>A	uc002nre.2	-	4	1621	c.1508C>T	c.(1507-1509)TCA>TTA	p.S503L	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.S471L	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	503	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGTAAGGGTTGAGGATTGCCT	0.368													11	31					0	0	0	0	A	23544273	A	A	23544273	3	1	15	1	0	0	0	0	1	0	0	0	18267	1294	45	2	2071	2	ZNF91	19	23544273	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	9	23544273	35584710	164	3367	8	2									
SLC7A10	56301	broad.mit.edu	37	chr19	33699842	33699842	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcaggcagcagggagggTgggcaggggccattctcctc	6	6	19	10	0	1	0	0	0	1	0	3	1	1	1	2	7	1	4	2	7	0	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:33699842T>G	uc002num.2	-	11	1674	c.1527A>C	c.(1525-1527)CCA>CCC	p.P509P	SLC7A10_uc002nul.2_Silent_p.P356P	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	509					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					GCAGGGAGGGTGGGCAGGGGC	0.547													10	70					0	0	0	0	G	33699842	G	G	33699842	2	3	15	1	0	0	0	0	0	0	0	1	14757	1683	59	5		5	SLC7A10	19	33699842	Silent	SNP	T	TCGA-BA-6868-01B-12D-1912-08	10155569	33699842	25429141	165	3368											
NPHS1	4868	broad.mit.edu	37	chr19	36335330	36335330	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctccaccgcggtcaccacCagcacctgctcccccaggaa	8	5	8	20	2	1	0	1	0	0	0	3	1	3	1	7	2	3	3	7	2	1	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:36335330C>T	uc002oby.2	-	15	1962	c.1962G>A	c.(1960-1962)CTG>CTA	p.L654L		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	654	Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGGTCACCACCAGCACCTGCT	0.537													3	3					0	0	0	0	T	36335330	T	T	36335330	2	4	15	1	0	0	0	0	0	0	0	1	10636	581	21	4		4	NPHS1	19	36335330	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	2635488	36335330	22793653	166	3369											
CYP2F1	1572	broad.mit.edu	37	chr19	41630665	41630665	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcgtggtgggacgcgcgCggctgccggcgctgaaggac	5	5	18	13	7	0	1	0	1	0	0	1	3	0	3	2	5	1	2	2	5	1	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:41630665C>T	uc002opu.1	+	8	1062	c.1006C>T	c.(1006-1008)CGG>TGG	p.R336W	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_Silent_p.R316R|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	336					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						GGGACGCGCGCGGCTGCCGGC	0.677													10	6					0	0	0	0	T	41630665	T	T	41630665	3	4	15	1	0	0	0	0	1	0	0	0	4188	759	27	1	1032	1	CYP2F1	19	41630665	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	5295335	41630665	17498318	167	3370											
MAMSTR	284358	broad.mit.edu	37	chr19	49216571	49216571	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagccggctgctgctggagtCagataagtcagcggagaaga	11	6	15	9	2	2	3	2	0	0	3	2	5	2	4	1	3	4	3	1	3	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:49216571C>G	uc002pkg.2	-	10	1263	c.1201G>C	c.(1201-1203)GAC>CAC	p.D401H	MAMSTR_uc002pkf.2_Missense_Mutation_p.D298H	NM_001130915	NP_001124387	Q6ZN01	MASTR_HUMAN	MEF2 activating motif and SAP domain containing	401	Ser-rich.|Transcription activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			ovary(1)	1						CTGCTGGAGTCAGATAAGTCA	0.617											OREG0025608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	17					0	0	0	0	G	49216571	G	G	49216571	3	3	15	1	0	0	0	0	1	0	0	0	9262	826	29	2	50	2	MAMSTR	19	49216571	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	7585906	49216571	9912412	168	3371											
ZNF446	55663	broad.mit.edu	37	chr19	58988810	58988810	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgctggagcagttcctGggcacactgcctcccgagat	6	9	13	13	1	0	1	0	0	0	1	2	3	2	2	3	3	3	4	3	3	0	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr19:58988810G>C	uc002qsz.2	+	2	342	c.225G>C	c.(223-225)CTG>CTC	p.L75L	ZNF446_uc002qta.2_Silent_p.L75L|ZNF446_uc010eur.2_Silent_p.L75L	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	75	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGCAGTTCCTGGGCACACTGC	0.662													28	45					0	0	0	0	C	58988810	C	C	58988810	2	2	15	1	0	0	0	0	0	0	0	1	17986	1335	47	4		4	ZNF446	19	58988810	Silent	SNP	G	TCGA-BA-6868-01B-12D-1912-08	9772239	58988810	140173	169	3372											
CDC25B	994	broad.mit.edu	37	chr20	3782640	3782640	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgccctgcagcgtgatccggCccatcctcaagaggctggag	7	7	13	14	2	1	2	1	1	0	1	3	3	3	3	4	3	3	2	4	3	1	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:3782640C>G	uc002wjn.2	+	10	1769	c.991C>G	c.(991-993)CCC>GCC	p.P331A	CDC25B_uc010zqk.1_Missense_Mutation_p.P267A|CDC25B_uc010zql.1_Missense_Mutation_p.P253A|CDC25B_uc010zqm.1_Missense_Mutation_p.P240A|CDC25B_uc002wjl.2_Missense_Mutation_p.P219A|CDC25B_uc002wjm.2_Missense_Mutation_p.P219A|CDC25B_uc002wjo.2_Missense_Mutation_p.P317A|CDC25B_uc002wjp.2_Missense_Mutation_p.P290A|CDC25B_uc002wjq.2_Missense_Mutation_p.P131A|CDC25B_uc010gbc.2_5'Flank	NM_021873	NP_068659	P30305	MPIP2_HUMAN	cell division cycle 25B isoform 1	331					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|ovary(2)	5						CGTGATCCGGCCCATCCTCAA	0.652													3	12					0	0	0	0	G	3782640	G	G	3782640	3	3	15	1	0	0	0	0	1	0	0	0	3078	739	26	4	1029	4	CDC25B	20	3782640	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08		3782640	59242880	170	3373											
C20orf103	24141	broad.mit.edu	37	chr20	9496163	9496180	+	In_Frame_Del	DEL	CTGAAAAAGATATATTTG	-	-																															ctcaggcctttccactaaccCtgaaaaagatatatttgtgg																										TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:9496163_9496180delCTGAAAAAGATATATTTG	uc002wni.1	+	2	357_374	c.128_145delCTGAAAAAGATATATTTG	c.(127-147)CCTGAAAAAGATATATTTGTG>CTG	p.43_49PEKDIFV>L	C20orf103_uc010zrc.1_In_Frame_Del_p.43_49PEKDIFV>L	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	43_49	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			TCCACTAACCCTGAAAAAGATATATTTGTGGTGCGGGA	0.436													---	---	---								-	9496180	-	-	9496163	7	5	15	1	0	1	0	1	0	0	0	0	2085	681	24	0	134	0	C20orf103	20	9496163	In_Frame_Del	DEL	CTGAAAAAGATATATTTG	TCGA-BA-6868-01B-12D-1912-08	5713523	9496163	53529357	171	3374											
AHCY	191	broad.mit.edu	37	chr20	32879320	32879320	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccccagtcgtggtctcctCagagatgcctcggatgccta	7	9	11	14	2	2	1	1	0	1	1	5	4	2	2	5	2	2	0	5	2	1	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:32879320C>T	uc002xai.2	-	5	602	c.463G>A	c.(463-465)GAG>AAG	p.E155K	AHCY_uc002xaj.2_Missense_Mutation_p.E127K	NM_000687	NP_000678	P23526	SAHH_HUMAN	adenosylhomocysteinase isoform 1	155					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding				0						GTGGTCTCCTCAGAGATGCCT	0.468													30	88					0	0	0	0	T	32879320	T	T	32879320	3	4	15	1	0	0	0	0	1	0	0	0	409	835	29	2	859	2	AHCY	20	32879320	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	23383157	32879320	30146200	172	3375											
PCIF1	63935	broad.mit.edu	37	chr20	44571864	44571864	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccatgtttcgtgaaatcAtgaacgacattcctatcagg	11	13	7	10	2	2	2	2	2	0	0	5	3	4	2	2	1	1	1	2	1	3	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr20:44571864A>G	uc002xqs.2	+	8	1116	c.802A>G	c.(802-804)ATG>GTG	p.M268V	PCIF1_uc002xqt.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	268						nucleus				skin(1)	1						TCGTGAAATCATGAACGACAT	0.537													24	128					0	0	0	0	G	44571864	G	G	44571864	3	3	15	1	0	0	0	0	1	0	0	0	11634	217	8	5	824	5	PCIF1	20	44571864	Missense_Mutation	SNP	A	TCGA-BA-6868-01B-12D-1912-08	11692544	44571864	18453656	173	3376											
TPTE	7179	broad.mit.edu	37	chr21	10933918	10933918	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agccatccactcatttacttCcttggtgaaaaccaccatct	11	12	4	14	0	2	1	1	1	1	0	4	1	4	1	5	1	3	0	5	1	3	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr21:10933918C>A	uc002yip.1	-	17	1329	c.961G>T	c.(961-963)GAA>TAA	p.E321*	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Nonsense_Mutation_p.E303*|TPTE_uc002yir.1_Nonsense_Mutation_p.E283*|TPTE_uc010gkv.1_Nonsense_Mutation_p.E183*	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	321	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCATTTACTTCCTTGGTGAAA	0.333													51	315					1.48341e-19	1.99069e-19	1	0	A	10933918	A	A	10933918	4	1	15	1	0	0	0	0	0	1	0	0	16497	864	30	2	726	2	TPTE	21	10933918	Nonsense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08		10933918	37195977	174	3377											
PCNT	5116	broad.mit.edu	37	chr21	47817314	47817314	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacagctgtctcagcatcGcgggtgtgccaagcaggcgg	9	6	15	11	3	1	1	1	0	1	1	3	1	1	1	1	3	5	3	1	3	2	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr21:47817314G>A	uc002zji.3	+	22	4459	c.4352G>A	c.(4351-4353)CGC>CAC	p.R1451H	PCNT_uc002zjj.2_Missense_Mutation_p.R1333H	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1451	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TCTCAGCATCGCGGGTGTGCC	0.567													29	23					0	0	0	0	A	47817314	A	A	47817314	3	1	15	1	0	0	0	0	1	0	0	0	11644	1087	38	1	4438	1	PCNT	21	47817314	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	36883396	47817314	312581	175	3378											
ZNF280B	140883	broad.mit.edu	37	chr22	22843615	22843615	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcagcatcttcatttacatGttccacaccaacaaagatga	14	11	4	12	0	3	2	2	1	1	1	4	2	4	2	2	0	3	2	2	0	3	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:22843615G>T	uc002zwc.1	-	4	885	c.109C>A	c.(109-111)CAT>AAT	p.H37N	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	37					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TCATTTACATGTTCCACACCA	0.418													31	68					3.80469e-20	5.13237e-20	1	0	T	22843615	T	T	22843615	3	4	15	1	0	0	0	0	1	0	0	0	17882	1377	48	4	1526	4	ZNF280B	22	22843615	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08		22843615	28460951	176	3379											
SLC2A11	66035	broad.mit.edu	37	chr22	24224830	24224830	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggagctctgcgggaatgaCtcggtgagacccctgccccg	7	7	14	13	3	1	2	0	2	1	1	2	5	1	4	4	3	3	1	4	3	1	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:24224830C>T	uc002zyn.3	+	7	969	c.870C>T	c.(868-870)GAC>GAT	p.D290D	SLC2A11_uc002zyl.1_Silent_p.D297D|SLC2A11_uc002zym.3_Silent_p.D297D|SLC2A11_uc002zyo.3_RNA|SLC2A11_uc011ajc.1_Silent_p.D297D|SLC2A11_uc002zyp.3_Silent_p.D293D	NM_001024938	NP_001020109	Q9BYW1	GTR11_HUMAN	glucose transporter protein 10 isoform c	290	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity			ovary(1)	1						GCGGGAATGACTCGGTGAGAC	0.687													4	15					0	0	0	0	T	24224830	T	T	24224830	2	4	15	1	0	0	0	0	0	0	0	1	14604	564	20	4		4	SLC2A11	22	24224830	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	1381215	24224830	27079736	177	3380											
MYO18B	84700	broad.mit.edu	37	chr22	26159338	26159338	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagaggaagcagttagctgtCgcctctccagaacgagaggt	11	7	13	10	2	1	3	0	0	1	3	3	5	1	4	2	2	3	3	2	2	3	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:26159338C>T	uc003abz.1	+	3	430	c.180C>T	c.(178-180)GTC>GTT	p.V60V	MYO18B_uc003aca.1_5'UTR|MYO18B_uc010guy.1_5'UTR|MYO18B_uc010guz.1_5'UTR|MYO18B_uc011aka.1_5'UTR	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	60						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AGTTAGCTGTCGCCTCTCCAG	0.512													13	13					0	0	0	0	T	26159338	T	T	26159338	2	4	15	1	0	0	0	0	0	0	0	1	10119	871	31	1		1	MYO18B	22	26159338	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	1934508	26159338	25145228	178	3381											
MYO18B	84700	broad.mit.edu	37	chr22	26423316	26423316	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gacacctacctccttggctgGatcagccaaaggtgggcaag	10	7	12	12	0	1	0	1	0	0	0	2	2	2	1	4	4	2	2	4	4	3	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:26423316G>C	uc003abz.1	+	43	7626	c.7376G>C	c.(7375-7377)GGA>GCA	p.G2459A	MYO18B_uc003aca.1_Missense_Mutation_p.G2340A|MYO18B_uc010guy.1_Missense_Mutation_p.G2341A|MYO18B_uc010guz.1_Missense_Mutation_p.G2339A|MYO18B_uc011aka.1_Missense_Mutation_p.G1613A|MYO18B_uc011akb.1_Missense_Mutation_p.G1972A|MYO18B_uc010gva.1_Missense_Mutation_p.G442A|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2459						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TCCTTGGCTGGATCAGCCAAA	0.532													56	83					0	0	0	0	C	26423316	C	C	26423316	3	2	15	1	0	0	0	0	1	0	0	0	10119	1174	41	2	7542	2	MYO18B	22	26423316	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	263978	26423316	24881250	179	3382											
MIOX	55586	broad.mit.edu	37	chr22	50926457	50926457	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagacagcggagggcatccGgaaggcccacccagacaagg	12	1	14	14	2	0	2	0	0	0	2	1	4	1	4	4	5	1	1	4	5	2	0			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chr22:50926457G>A	uc003bll.1	+	4	434	c.320G>A	c.(319-321)CGG>CAG	p.R107Q	MIOX_uc003blm.1_Missense_Mutation_p.R107Q|MIOX_uc003bln.1_Missense_Mutation_p.R107Q	NM_017584	NP_060054	Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	107					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GAGGGCATCCGGAAGGCCCAC	0.652													15	46					0	0	0	0	A	50926457	A	A	50926457	3	1	15	1	0	0	0	0	1	0	0	0	9643	1116	39	1	334	1	MIOX	22	50926457	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	24503141	50926457	378109	180	3383											
MXRA5	25878	broad.mit.edu	37	chrX	3241328	3241328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttaatcaatgggggtacttCtgtgcccttagggagatttt	8	16	11	6	0	2	1	1	0	1	1	2	2	2	1	1	3	2	1	1	3	4	7			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:3241328C>T	uc004crg.3	-	5	2555	c.2398G>A	c.(2398-2400)GAA>AAA	p.E800K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	800						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGGGGTACTTCTGTGCCCTTA	0.468													27	16					0	0	0	0	T	3241328	T	T	3241328	3	4	15	1	0	0	0	0	1	0	0	0	10056	922	32	2	6100	2	MXRA5	23	3241328	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08		3241328	152029232	181	3384											
FRMPD4	9758	broad.mit.edu	37	chrX	12701691	12701691	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctctgaggaggtcatcatCaacggccaagtgtcggtgag	9	10	13	9	2	4	2	3	2	1	0	6	3	4	3	1	4	1	0	1	4	2	1			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:12701691C>T	uc004cuz.1	+	6	1064	c.558C>T	c.(556-558)ATC>ATT	p.I186I	FRMPD4_uc011mij.1_Silent_p.I178I	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	186					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGGTCATCATCAACGGCCAAG	0.443													19	8					0	0	0	0	T	12701691	T	T	12701691	2	4	15	1	0	0	0	0	0	0	0	1	6093	816	29	2		2	FRMPD4	23	12701691	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	9460363	12701691	142568869	182	3385											
GPR64	10149	broad.mit.edu	37	chrX	19022962	19022962	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaatgaacgtcagagccatCatttgagcaggcagcacaga	14	7	11	9	1	2	4	2	2	0	2	2	4	2	4	1	1	4	4	1	1	2	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:19022962C>A	uc004cyx.2	-	23	2039	c.1875G>T	c.(1873-1875)ATG>ATT	p.M625I	GPR64_uc004cyy.2_Missense_Mutation_p.M622I|GPR64_uc004cyz.2_Missense_Mutation_p.M611I|GPR64_uc004czb.2_Missense_Mutation_p.M625I|GPR64_uc004czc.2_Missense_Mutation_p.M609I|GPR64_uc004czd.2_Missense_Mutation_p.M601I|GPR64_uc004cze.2_Missense_Mutation_p.M595I|GPR64_uc004czf.2_Missense_Mutation_p.M587I|GPR64_uc004cza.2_Missense_Mutation_p.M603I|GPR64_uc004cyw.2_Missense_Mutation_p.M609I|GPR64_uc010nfj.2_Missense_Mutation_p.M506I	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	625	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					TCAGAGCCATCATTTGAGCAG	0.333													84	31					1.79992e-35	2.49293e-35	1	0	A	19022962	A	A	19022962	3	1	15	1	0	0	0	0	1	0	0	0	6743	826	29	2	1206	2	GPR64	23	19022962	Missense_Mutation	SNP	C	TCGA-BA-6868-01B-12D-1912-08	6321271	19022962	136247598	183	3386											
P2RY10	27334	broad.mit.edu	37	chrX	78216656	78216656	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgtgatcccagtgatcatCatcgcatggtgtacctggaa	9	13	10	9	1	2	2	2	2	0	0	4	3	3	3	2	2	1	2	2	2	2	2			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:78216656C>T	uc004ede.2	+	4	1008	c.639C>T	c.(637-639)ATC>ATT	p.I213I	P2RY10_uc004edf.2_Silent_p.I213I	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	213	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CAGTGATCATCATCGCATGGT	0.478													38	13					0	0	0	0	T	78216656	T	T	78216656	2	4	15	1	0	0	0	0	0	0	0	1	11401	816	29	2		2	P2RY10	23	78216656	Silent	SNP	C	TCGA-BA-6868-01B-12D-1912-08	59193694	78216656	77053904	184	3387											
IRS4	8471	broad.mit.edu	37	chrX	107977584	107977584	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcttctttgcattctttcGtggctcctctgtcaacacaa	6	16	7	12	1	4	0	1	0	3	0	6	0	5	0	1	2	2	3	1	2	2	4			TCGA-BA-6868-01B-12D-1912-08	TCGA-BA-6868-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	51647474-f538-4e96-babd-e742f1fb793f	9c4cf4d1-4c14-4575-898a-6b6ad2e9aa65	g.chrX:107977584G>A	uc004eoc.2	-	1	2024	c.1991C>T	c.(1990-1992)ACG>ATG	p.T664M		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	664						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GCATTCTTTCGTGGCTCCTCT	0.512													219	77					0	0	0	0	A	107977584	A	A	107977584	3	1	15	1	0	0	0	0	1	0	0	0	7881	1145	40	1	1786	1	IRS4	23	107977584	Missense_Mutation	SNP	G	TCGA-BA-6868-01B-12D-1912-08	29760928	107977584	47292976	185	3388											
ATAD3B	83858	broad.mit.edu	37	chr1	1430870	1430870	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctctcttcactaggccacGgcatatgcctccaaggacgg	8	9	9	15	2	3	0	1	0	2	0	5	1	4	1	3	4	1	1	3	4	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:1430870G>A	uc001afv.2	+	16	1721	c.1620G>A	c.(1618-1620)ACG>ACA	p.T540T	ATAD3B_uc001afx.2_Silent_p.T494T|ATAD3B_uc001afy.2_Silent_p.T93T	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	540							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		ACTAGGCCACGGCATATGCCT	0.632													23	15					0	0	0	0	A	1430870	A	A	1430870	2	1	16	1	0	0	0	0	0	0	0	1	1076	1103	39	1		1	ATAD3B	1	1430870	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08		1430870	247819751	1	3389											
SLC35E2	9906	broad.mit.edu	37	chr1	1670363	1670363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccaggagattctttacctCatcagacccacaaacagcat	15	8	5	13	0	3	2	2	0	1	2	3	3	3	2	3	1	4	1	3	1	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:1670363C>T	uc001aib.1	-	3	872	c.456G>A	c.(454-456)ATG>ATA	p.M152I	SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Missense_Mutation_p.M152I|SLC35E2_uc001ahy.2_Missense_Mutation_p.M152I|SLC35E2_uc001ahz.2_Missense_Mutation_p.M152I	NM_182838	NP_878258	P0CK97	S35E2_HUMAN	solute carrier family 35, member E2	152	Helical; (Potential).					integral to membrane				pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTCTTTACCTCATCAGACCCA	0.473													8	28					0	0	0	0	T	1670363	T	T	1670363	3	4	16	1	0	0	0	0	1	0	0	0	14649	826	29	2	1610	2	SLC35E2	1	1670363	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	239493	1670363	247580258	2	3390											
AJAP1	55966	broad.mit.edu	37	chr1	4772252	4772252	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccacaggccccgggaccagGcggccgccctcgtgcccaag	6	2	13	20	4	0	0	0	0	0	0	1	1	0	1	7	4	1	0	7	4	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:4772252G>C	uc001alm.1	+	2	703	c.322G>C	c.(322-324)GCG>CCG	p.A108P	AJAP1_uc001aln.2_Missense_Mutation_p.A108P	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	108	Extracellular (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CCGGGACCAGGCGGCCGCCCT	0.736													2	7					0	0	0	0	C	4772252	C	C	4772252	3	2	16	1	0	0	0	0	1	0	0	0	438	1203	42	4	328	4	AJAP1	1	4772252	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3101889	4772252	244478369	3	3391											
CAMTA1	23261	broad.mit.edu	37	chr1	7723703	7723703	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtccatcagcagcgggCtcaacagcgacccggacatg	9	6	12	14	3	2	0	2	0	0	0	3	2	3	1	2	2	4	2	2	2	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:7723703C>A	uc001aoi.2	+	9	1303	c.1096C>A	c.(1096-1098)CTC>ATC	p.L366I		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CAGCAGCGGGCTCAACAGCGA	0.662													33	60					1.04352e-10	1.26206e-10	1	0	A	7723703	A	A	7723703	3	1	16	1	0	0	0	0	1	0	0	0	2625	797	28	4	1130	4	CAMTA1	1	7723703	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2951451	7723703	241526918	4	3392											
KIAA2013	90231	broad.mit.edu	37	chr1	11982754	11982754	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttgtagatgagcttgaagAggaagaggtggaagagggtg	12	8	19	2	1	0	6	0	2	0	4	0	8	0	8	0	4	1	3	0	4	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:11982754A>C	uc001atk.2	-	2	2020	c.1826T>G	c.(1825-1827)CTC>CGC	p.L609R	KIAA2013_uc001atl.1_Missense_Mutation_p.L609R	NM_138346	NP_612355	Q8IYS2	K2013_HUMAN	hypothetical protein LOC90231 precursor	609	Helical; (Potential).					integral to membrane				ovary(1)	1	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCTTGAAGAGGAAGAGGTG	0.597													10	20					0	0	0	0	C	11982754	C	C	11982754	3	2	16	1	0	0	0	0	1	0	0	0	8306	304	11	5	86	5	KIAA2013	1	11982754	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	4259051	11982754	237267867	5	3393											
PRAMEF1	65121	broad.mit.edu	37	chr1	12854287	12854287	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgagatacctcttccagtggGtttaccaaaggagaggttta	11	12	11	7	0	1	2	0	1	1	2	2	4	2	2	3	3	2	2	3	3	4	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:12854287G>A	uc001auj.1	+	3	614	c.511G>A	c.(511-513)GTT>ATT	p.V171I		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	171											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTTCCAGTGGGTTTACCAAAG	0.433													83	283					0	0	0	0	A	12854287	A	A	12854287	3	1	16	1	0	0	0	0	1	0	0	0	12485	1261	44	4	517	4	PRAMEF1	1	12854287	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	871533	12854287	236396334	6	3394											
PRAMEF4	400735	broad.mit.edu	37	chr1	12939515	12939515	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atttgagcaaatctgctccaGcagagagtaccatcagcacc	13	8	8	12	0	2	2	1	1	1	1	3	3	3	2	3	0	5	5	3	0	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:12939515G>T	uc001aun.2	-	4	1358	c.1287C>A	c.(1285-1287)TGC>TGA	p.C429*		NM_001009611	NP_001009611	O60810	PRAM4_HUMAN	PRAME family member 4	429										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATCTGCTCCAGCAGAGAGTAC	0.512													97	173					1.09907e-53	1.68946e-53	1	0	T	12939515	T	T	12939515	4	4	16	1	0	0	0	0	0	1	0	0	12499	963	34	4	153	4	PRAMEF4	1	12939515	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	85228	12939515	236311106	7	3395											
CLCNKB	1188	broad.mit.edu	37	chr1	16378026	16378026	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcctgccgggtacttcatGcccatctttgtctatggtga	6	14	10	11	1	3	1	1	1	2	0	3	1	3	1	3	2	4	1	3	2	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:16378026G>T	uc001axw.3	+	13	1361	c.1281G>T	c.(1279-1281)ATG>ATT	p.M427I	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.M427I|CLCNKB_uc001axy.3_Missense_Mutation_p.M258I	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	427	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		GGTACTTCATGCCCATCTTTG	0.592													48	104					1.65492e-34	2.50189e-34	1	0	T	16378026	T	T	16378026	3	4	16	1	0	0	0	0	1	0	0	0	3485	1319	46	4	1475	4	CLCNKB	1	16378026	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3438511	16378026	232872595	8	3396											
CAPZB	832	broad.mit.edu	37	chr1	19671737	19671737	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcagtcactcacagtttcatCcttctccatctgcaaaagac	11	11	5	14	0	5	1	3	0	2	1	7	1	6	1	2	0	1	3	2	0	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:19671737C>G	uc010ocz.1	-	7	1113	c.685G>C	c.(685-687)GAT>CAT	p.D229H	CAPZB_uc001bce.2_Missense_Mutation_p.D200H|CAPZB_uc009vpk.2_Missense_Mutation_p.D226H|CAPZB_uc001bcd.2_Missense_Mutation_p.D188H	NM_004930	NP_004921	P47756	CAPZB_HUMAN	F-actin capping protein beta subunit	200					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement	cytosol|F-actin capping protein complex|WASH complex	actin binding				0		Colorectal(325;3.93e-05)|Renal(390;0.000147)|all_lung(284;0.000169)|Lung NSC(340;0.000202)|Breast(348;0.000496)|Ovarian(437;0.00428)|Myeloproliferative disorder(586;0.0262)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Kidney(64;8.63e-06)|BRCA - Breast invasive adenocarcinoma(304;4.06e-05)|KIRC - Kidney renal clear cell carcinoma(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000525)|STAD - Stomach adenocarcinoma(196;0.00779)|READ - Rectum adenocarcinoma(331;0.103)|Lung(427;0.173)		ACAGTTTCATCCTTCTCCATC	0.557													4	110					0	0	0	0	G	19671737	G	G	19671737	3	3	16	1	0	0	0	0	1	0	0	0	2655	855	30	2	232	2	CAPZB	1	19671737	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3293711	19671737	229578884	9	3397											
CNKSR1	10256	broad.mit.edu	37	chr1	26510929	26510929	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgagcccctgcccatcccCccggaacccccagccatact	7	5	6	23	1	0	1	0	1	0	0	1	2	1	2	10	1	5	0	10	1	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:26510929C>T	uc001bln.3	+	12	1117	c.1059C>T	c.(1057-1059)CCC>CCT	p.P353P	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Silent_p.P346P|CNKSR1_uc009vsd.2_Silent_p.P88P|CNKSR1_uc009vse.2_Silent_p.P88P|CNKSR1_uc001blo.2_Silent_p.P88P	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	353	Pro-rich.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCCATCCCCCCGGAACCCC	0.637													13	17					0	0	0	0	T	26510929	T	T	26510929	2	4	16	1	0	0	0	0	0	0	0	1	3621	610	22	4		4	CNKSR1	1	26510929	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	6839192	26510929	222739692	10	3398											
MATN1	4146	broad.mit.edu	37	chr1	31187158	31187158	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatttcaccagggactcgcaGgcacacgggtcttcctctgc	8	9	10	14	2	3	0	1	0	2	0	5	1	4	1	2	3	1	2	2	3	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:31187158G>A	uc001brz.2	-	7	1411	c.1377C>T	c.(1375-1377)GCC>GCT	p.A459A	MATN1_uc001bsa.1_Silent_p.A377A	NM_002379	NP_002370	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein precursor	459					protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)	1		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		GGGACTCGCAGGCACACGGGT	0.627													4	13					0	0	0	0	A	31187158	A	A	31187158	2	1	16	1	0	0	0	0	0	0	0	1	9386	987	35	4		4	MATN1	1	31187158	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4676229	31187158	218063463	11	3399											
SPOCD1	90853	broad.mit.edu	37	chr1	32267266	32267266	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataaaatgtaaaaacctacgTagcacacaagcttcactcca	18	8	4	11	1	1	0	1	0	0	0	2	0	2	0	2	0	4	4	2	0	8	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:32267266T>C	uc001bts.1	-	3	1482	c.1424A>G	c.(1423-1425)TAC>TGC	p.Y475C	SPOCD1_uc001btt.2_5'Flank|SPOCD1_uc001btu.2_Missense_Mutation_p.Y475C|SPOCD1_uc001btv.2_5'UTR	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	475					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		AAAACCTACGTAGCACACAAG	0.507													22	57					0	0	0	0	C	32267266	C	C	32267266	3	2	16	1	0	0	0	0	1	0	0	0	15144	1652	57	5	2282	5	SPOCD1	1	32267266	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	1080108	32267266	216983355	12	3400											
TIE1	7075	broad.mit.edu	37	chr1	43772569	43772569	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatgggcggttcctgctgcaGctcccaaatgtgcagccacc	7	8	12	14	1	0	0	0	0	0	0	2	1	2	0	4	2	5	5	4	2	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:43772569G>C	uc001ciu.2	+	4	622	c.543G>C	c.(541-543)CAG>CAC	p.Q181H	TIE1_uc010okd.1_Missense_Mutation_p.Q181H|TIE1_uc010oke.1_Missense_Mutation_p.Q136H|TIE1_uc009vwq.2_Missense_Mutation_p.Q181H|TIE1_uc010okf.1_5'UTR|TIE1_uc010okg.1_5'Flank|TIE1_uc010okb.1_Missense_Mutation_p.Q181H|TIE1_uc010okc.1_Missense_Mutation_p.Q181H	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	181	Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCCTGCTGCAGCTCCCAAATG	0.607													18	46					0	0	0	0	C	43772569	C	C	43772569	3	2	16	1	0	0	0	0	1	0	0	0	15959	962	34	4	557	4	TIE1	1	43772569	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	11505303	43772569	205478052	13	3401											
CC2D1B	200014	broad.mit.edu	37	chr1	52826198	52826198	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccgttcctccagcaaagcGtgtagcccctgagatgctcc	8	9	9	15	2	0	1	0	1	0	1	4	2	4	1	6	0	4	4	6	0	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:52826198G>A	uc001ctq.1	-	6	639	c.501C>T	c.(499-501)CAC>CAT	p.H167H	CC2D1B_uc001ctr.2_5'Flank|CC2D1B_uc001cts.2_5'Flank	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	167	Potential.									ovary(2)	2						CCAGCAAAGCGTGTAGCCCCT	0.632													11	23					0	0	0	0	A	52826198	A	A	52826198	2	1	16	1	0	0	0	0	0	0	0	1	2739	1136	40	1		1	CC2D1B	1	52826198	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	9053629	52826198	196424423	14	3402											
LRRC7	57554	broad.mit.edu	37	chr1	70300502	70300502	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagctcctaaacctgacccaGctctacctgaatgacgcctt	10	9	6	16	1	1	3	0	3	1	0	2	3	2	3	5	0	4	2	5	0	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:70300502G>T	uc001dep.2	+	4	456	c.426G>T	c.(424-426)CAG>CAT	p.Q142H	LRRC7_uc001deo.1_Missense_Mutation_p.Q180H|LRRC7_uc009wbg.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	142	LRR 6.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						ACCTGACCCAGCTCTACCTGA	0.358													23	47					6.21321e-17	8.40225e-17	1	0	T	70300502	T	T	70300502	3	4	16	1	0	0	0	0	1	0	0	0	9070	962	34	4	440	4	LRRC7	1	70300502	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	17474304	70300502	178950119	15	3403											
C1orf173	127254	broad.mit.edu	37	chr1	75097586	75097586	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtgaattgcctatggagttCctgaacttcatcactgcctt	8	15	8	10	0	2	2	2	2	0	0	3	3	3	3	3	1	3	1	3	1	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:75097586C>A	uc001dgg.2	-	7	849	c.630G>T	c.(628-630)AGG>AGT	p.R210S	C1orf173_uc001dgi.3_Missense_Mutation_p.R4S	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	210										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTATGGAGTTCCTGAACTTCA	0.393													39	51					1.47244e-24	2.13538e-24	1	0	A	75097586	A	A	75097586	3	1	16	1	0	0	0	0	1	0	0	0	2023	854	30	2	3994	2	C1orf173	1	75097586	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4797084	75097586	174153035	16	3404											
FAM73A	374986	broad.mit.edu	37	chr1	78332059	78332059	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggtcggtgctgaaacagAaaagacaacagatgaaggta	16	7	13	5	1	0	5	0	2	0	3	1	5	0	5	0	3	3	3	0	3	6	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:78332059A>T	uc001dhx.2	+	14	1578	c.1546A>T	c.(1546-1548)AAA>TAA	p.K516*	FAM73A_uc010ork.1_Nonsense_Mutation_p.K516*|FAM73A_uc010orl.1_Nonsense_Mutation_p.K478*	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	516						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		GCTGAAACAGAAAAGACAACA	0.353													28	69					0	0	0	0	T	78332059	T	T	78332059	4	4	16	1	0	0	0	0	0	1	0	0	5649	247	9	5	1600	5	FAM73A	1	78332059	Nonsense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	3234473	78332059	170918562	17	3405											
LPHN2	23266	broad.mit.edu	37	chr1	82416749	82416749	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccactggaacatggaaccctAagggccccgatcttagcaac	12	6	9	14	1	1	0	0	0	1	0	1	3	1	2	4	3	4	1	4	3	5	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:82416749A>G	uc001dit.3	+	8	1721	c.1540A>G	c.(1540-1542)AAG>GAG	p.K514E	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.K514E|LPHN2_uc001div.2_Missense_Mutation_p.K514E|LPHN2_uc009wcd.2_Missense_Mutation_p.K514E|LPHN2_uc001diw.2_Missense_Mutation_p.K85E	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	514	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ATGGAACCCTAAGGGCCCCGA	0.438													29	67					0	0	0	0	G	82416749	G	G	82416749	3	3	16	1	0	0	0	0	1	0	0	0	8966	363	13	5	1562	5	LPHN2	1	82416749	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	4084690	82416749	166833872	18	3406											
CLCA1	1179	broad.mit.edu	37	chr1	86961284	86961284	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaaagtgcgggctctgggagGagttaacgcagccagacgga	12	5	16	8	3	1	1	0	0	1	1	1	4	1	4	1	4	3	3	1	4	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:86961284G>A	uc001dlt.2	+	12	2168	c.2039G>A	c.(2038-2040)GGA>GAA	p.G680E		NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	680					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GCTCTGGGAGGAGTTAACGCA	0.463													22	40					0	0	0	0	A	86961284	A	A	86961284	3	1	16	1	0	0	0	0	1	0	0	0	3472	1174	41	2	2085	2	CLCA1	1	86961284	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4544535	86961284	162289337	19	3407											
EVI5	7813	broad.mit.edu	37	chr1	93167773	93167773	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatctactaaagagtaagcCtaaaaagtaaaaaaaagttg	21	8	7	5	1	1	1	0	0	1	1	1	2	1	1	1	0	2	3	1	0	11	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:93167773C>A	uc001dox.2	-	5	707	c.697_splice	c.e5-1	p.A233_splice	EVI5_uc010otf.1_Splice_Site_p.A233_splice	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5						cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		AAGAGTAAGCCTAAAAAGTAA	0.303													15	21					1.05317e-09	1.24554e-09	1	0	A	93167773	A	A	93167773	5	1	16	1	0	0	0	0	0	0	1	0	5313	695	24	4	1792	4	EVI5	1	93167773	Splice_Site	SNP	C	TCGA-BA-6869-01A-11D-1870-08	6206489	93167773	156082848	20	3408											
NTNG1	22854	broad.mit.edu	37	chr1	107691139	107691139	+	Translation_Start_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acatacatatgtgtatatatAtgtaaactagacaaagatcg	18	12	6	5	1	0	2	0	0	0	2	1	2	0	2	0	0	2	2	0	0	10	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:107691139A>G	uc001dvh.3	+	2	642	c.-76A>G	c.(-78--74)ATATG>ATGTG		NTNG1_uc001dvf.3_Translation_Start_Site|NTNG1_uc010out.1_Translation_Start_Site|NTNG1_uc001dvc.3_Translation_Start_Site|NTNG1_uc001dvd.1_Translation_Start_Site	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1						axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GTGTATATATATGTAAACTAG	0.348													15	35					0	0	0	0	G	107691139	G	G	107691139	1	3	16	1	0	0	0	0	0	0	0	0	10758	464	16	5		5	NTNG1	1	107691139	Translation_Start_Site	SNP	A	TCGA-BA-6869-01A-11D-1870-08	14523366	107691139	141559482	21	3409											
GNAI3	2773	broad.mit.edu	37	chr1	110129355	110129355	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttatttctttttcagaaccGaatgcatgaaagcatgaaac	14	14	6	7	1	2	3	1	2	1	1	2	4	2	3	1	0	4	2	1	0	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:110129355G>A	uc001dxz.2	+	7	882	c.725G>A	c.(724-726)CGA>CAA	p.R242Q		NM_006496	NP_006487	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein),	242					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		TTTCAGAACCGAATGCATGAA	0.318													16	26					0	0	0	0	A	110129355	A	A	110129355	3	1	16	1	0	0	0	0	1	0	0	0	6543	1058	37	1	751	1	GNAI3	1	110129355	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2438216	110129355	139121266	22	3410											
WARS2	10352	broad.mit.edu	37	chr1	119575893	119575893	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactatctcctctgggctgtCtgttattcggacggtggcca	5	13	11	12	2	3	0	0	0	3	0	5	1	3	1	2	4	0	2	2	4	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:119575893C>A	uc001ehn.2	-	6	752	c.724G>T	c.(724-726)GAC>TAC	p.D242Y	WARS2_uc010oxf.1_Missense_Mutation_p.D148Y|WARS2_uc001ehm.2_3'UTR|WARS2_uc010oxg.1_Missense_Mutation_p.D185Y|WARS2_uc010oxh.1_3'UTR	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	242					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	TCTGGGCTGTCTGTTATTCGG	0.517													50	91					4.01344e-20	5.5564e-20	1	0	A	119575893	A	A	119575893	3	1	16	1	0	0	0	0	1	0	0	0	17318	913	32	2	362	2	WARS2	1	119575893	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	9446538	119575893	129674728	23	3411											
SNX27	81609	broad.mit.edu	37	chr1	151611499	151611499	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctagatcccagtgacgactcGttgggacaatcattttatga	11	12	9	9	2	1	3	1	2	0	1	3	5	2	4	1	1	0	1	1	1	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:151611499G>T	uc001eyn.1	+	2	463	c.447G>T	c.(445-447)TCG>TCT	p.S149S	SNX27_uc001eyo.2_Silent_p.S56S|SNX27_uc001eyp.2_5'UTR	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	149					cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTGACGACTCGTTGGGACAAT	0.468													25	53					1.64293e-13	2.10624e-13	1	0	T	151611499	T	T	151611499	2	4	16	1	0	0	0	0	0	0	0	1	14961	1132	40	3		3	SNX27	1	151611499	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	32035606	151611499	97639122	24	3412											
LINGO4	339398	broad.mit.edu	37	chr1	151774763	151774763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaacaatctggttgaggcGgaggtccagcagggtcagag	11	6	17	7	1	2	3	1	1	1	2	3	5	3	4	1	5	2	2	1	5	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:151774763G>A	uc001ezf.1	-	2	608	c.418C>T	c.(418-420)CGC>TGC	p.R140C		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	140	Extracellular (Potential).|LRR 4.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGGTTGAGGCGGAGGTCCAGC	0.582													35	69					0	0	0	0	A	151774763	A	A	151774763	3	1	16	1	0	0	0	0	1	0	0	0	8859	1116	39	1	1367	1	LINGO4	1	151774763	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	163264	151774763	97475858	25	3413											
FLG	2312	broad.mit.edu	37	chr1	152284331	152284331	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtccaccagaggaagtctCtgcgtgaggagttcctgatt	8	11	12	10	1	1	3	0	2	1	1	4	5	3	5	3	2	1	1	3	2	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:152284331C>G	uc001ezu.1	-	3	3067	c.3031G>C	c.(3031-3033)GAG>CAG	p.E1011Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1011	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGAAGTCTCTGCGTGAGGA	0.582									Ichthyosis				138	260					0	0	0	0	G	152284331	G	G	152284331	3	3	16	1	0	0	0	0	1	0	0	0	5954	922	32	2	9158	2	FLG	1	152284331	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	509568	152284331	96966290	26	3414											
OR10T2	128360	broad.mit.edu	37	chr1	158369186	158369186	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacaaaaagcagcagctggAgctcccccaggctggagaaa	14	4	12	11	0	0	2	0	1	0	1	1	4	1	3	2	3	4	5	2	3	3	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:158369186A>T	uc010pih.1	-	1	71	c.71T>A	c.(70-72)CTC>CAC	p.L24H		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CAGCAGCTGGAGCTCCCCCAG	0.483													11	29					0	0	0	0	T	158369186	T	T	158369186	3	4	16	1	0	0	0	0	1	0	0	0	10973	304	11	5	875	5	OR10T2	1	158369186	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	6084855	158369186	90881435	27	3415											
IGSF9	57549	broad.mit.edu	37	chr1	159898079	159898079	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctgtggaggggggccgcagGaacgaagcgctgcctcgccc	6	4	18	13	4	0	0	0	0	0	0	1	3	0	2	3	5	3	3	3	5	2	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:159898079G>A	uc001fur.2	-	19	3297	c.3099C>T	c.(3097-3099)TTC>TTT	p.F1033F	IGSF9_uc001fuq.2_Silent_p.F1017F|CCDC19_uc001ful.2_5'Flank|TAGLN2_uc001fun.1_5'Flank|TAGLN2_uc001fuo.1_5'Flank|TAGLN2_uc010piy.1_5'Flank|IGSF9_uc001fup.2_Silent_p.F179F	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	1033	Cytoplasmic (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GGGGCCGCAGGAACGAAGCGC	0.697													13	17					0	0	0	0	A	159898079	A	A	159898079	2	1	16	1	0	0	0	0	0	0	0	1	7644	1165	41	2		2	IGSF9	1	159898079	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1528893	159898079	89352542	28	3416											
SLAMF7	57823	broad.mit.edu	37	chr1	160708975	160708976	+	5'Flank	INS	-	TCACA	TCACA																															aatttagcaattactcaatcINStcacatgtctgcggcgtgac																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:160708975_160708976insTCACA	uc001fwq.2	+						SLAMF7_uc010pjn.1_5'Flank|SLAMF7_uc001fws.2_5'Flank|SLAMF7_uc001fwr.2_5'Flank|SLAMF7_uc010pjo.1_5'Flank|SLAMF7_uc010pjp.1_5'Flank|SLAMF7_uc010pjq.1_5'Flank|SLAMF7_uc010pjr.1_5'Flank	NM_021181	NP_067004	Q9NQ25	SLAF7_HUMAN	SLAM family member 7						cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			skin(2)|ovary(1)	3	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			attactcaATCTCACATGTCTG	0.252													---	---	---								TCACA	160708976	TCACA	TCACA	160708975	6	5	16	0	1	1	1	0	0	0	0	0	14434	928	32	0		0	SLAMF7	1	160708975	5'Flank	INS	-	TCGA-BA-6869-01A-11D-1870-08	810896	160708975	88541646	29	3417											
FCGR3B	2215	broad.mit.edu	37	chr1	161599754	161599754	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaggctccctggcacttcaGagtcacactgtccttctcaa	8	11	8	14	0	3	1	3	0	1	1	6	1	5	1	2	2	0	3	2	2	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:161599754G>C	uc009wul.2	-	3	407	c.133C>G	c.(133-135)CTG>GTG	p.L45V		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	45	Ig-like C2-type 1.				immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TGGCACTTCAGAGTCACACTG	0.532													24	74					0	0	0	0	C	161599754	C	C	161599754	3	2	16	1	0	0	0	0	1	0	0	0	5817	933	33	2	580	2	FCGR3B	1	161599754	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	890779	161599754	87650867	30	3418											
PRRX1	5396	broad.mit.edu	37	chr1	170633413	170633413	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccggcgctgggcggccgCttggacagcccgggcaacct	6	4	15	16	5	0	0	0	0	0	0	0	1	0	1	4	5	3	3	4	5	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:170633413C>A	uc001ghf.2	+	1	101	c.54C>A	c.(52-54)CGC>CGA	p.R18R	PRRX1_uc001ghe.2_Silent_p.R18R	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	18						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGGCGGCCGCTTGGACAGCC	0.662													14	19					6.31663e-08	7.179e-08	1	0	A	170633413	A	A	170633413	2	1	16	1	0	0	0	0	0	0	0	1	12674	784	28	4		4	PRRX1	1	170633413	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	9033659	170633413	78617208	31	3419											
TNN	63923	broad.mit.edu	37	chr1	175092651	175092651	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtgcgctacacctctgcTgacggagagaccagggaggt	9	7	15	10	2	1	2	0	1	1	1	1	5	1	4	2	4	3	2	2	4	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:175092651T>A	uc001gkl.1	+	12	2879	c.2766T>A	c.(2764-2766)GCT>GCA	p.A922A		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	922	Fibronectin type-III 8.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACACCTCTGCTGACGGAGAGA	0.597													17	59					0	0	0	0	A	175092651	A	A	175092651	2	1	16	1	0	0	0	0	0	0	0	1	16389	1567	55	5		5	TNN	1	175092651	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	4459238	175092651	74157970	32	3420											
PAPPA2	60676	broad.mit.edu	37	chr1	176526361	176526361	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccggagggaggacagaacaaCccagccatcatcgcaggtaa	14	3	12	12	2	1	1	1	0	0	1	2	4	1	4	3	4	3	2	3	4	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:176526361C>A	uc001gkz.2	+	2	2067	c.903C>A	c.(901-903)AAC>AAA	p.N301K	PAPPA2_uc001gky.1_Missense_Mutation_p.N301K|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	301					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GACAGAACAACCCAGCCATCA	0.577													4	13					0.000602214	0.000626655	1	0	A	176526361	A	A	176526361	3	1	16	1	0	0	0	0	1	0	0	0	11487	506	18	4	905	4	PAPPA2	1	176526361	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1433710	176526361	72724260	33	3421											
F13B	2165	broad.mit.edu	37	chr1	197030098	197030098	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctctgtcttctttcctccagCtgtgtagtagccagtagcac	6	14	8	13	0	3	0	0	0	3	0	5	0	5	0	3	0	3	5	3	0	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:197030098C>A	uc001gtt.1	-	4	603	c.559G>T	c.(559-561)GCT>TCT	p.A187S		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	187	Sushi 3.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTTCCTCCAGCTGTGTAGTAG	0.388													30	84					3.1745e-13	4.05349e-13	1	0	A	197030098	A	A	197030098	3	1	16	1	0	0	0	0	1	0	0	0	5366	797	28	4	1462	4	F13B	1	197030098	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	20503737	197030098	52220523	34	3422											
PTPRC	5788	broad.mit.edu	37	chr1	198687375	198687375	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggttagaaatgagtcgcatAagaattgcgatttccgtgta	12	13	11	5	3	0	3	0	1	0	2	2	4	1	3	1	1	1	3	1	1	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:198687375A>G	uc001gur.1	+	14	1777	c.1597A>G	c.(1597-1599)AAG>GAG	p.K533E	PTPRC_uc001gus.1_Missense_Mutation_p.K485E|PTPRC_uc001gut.1_Missense_Mutation_p.K372E|PTPRC_uc009wzf.1_Missense_Mutation_p.K421E|PTPRC_uc010ppg.1_Missense_Mutation_p.K469E	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	533	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TGAGTCGCATAAGAATTGCGA	0.398													12	22					0	0	0	0	G	198687375	G	G	198687375	3	3	16	1	0	0	0	0	1	0	0	0	12862	363	13	5	1658	5	PTPRC	1	198687375	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	1657277	198687375	50563246	35	3423											
KIF21B	23046	broad.mit.edu	37	chr1	200954076	200954076	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgagtgggaggggatgatggGggtgtgaatcccacatctgt	8	9	18	6	1	1	2	0	2	1	0	2	5	2	4	1	5	0	0	1	5	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:200954076G>C	uc001gvs.1	-	27	4031	c.3714C>G	c.(3712-3714)CCC>CCG	p.P1238P	KIF21B_uc001gvr.1_Silent_p.P1238P|KIF21B_uc009wzl.1_Silent_p.P1238P|KIF21B_uc010ppn.1_Silent_p.P1238P	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1238					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGGATGATGGGGGTGTGAATC	0.612													14	52					0	0	0	0	C	200954076	C	C	200954076	2	2	16	1	0	0	0	0	0	0	0	1	8328	1219	43	4		4	KIF21B	1	200954076	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2266701	200954076	48296545	36	3424											
AVPR1B	553	broad.mit.edu	37	chr1	206224591	206224591	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcctggtgctggcgaccgggGgcaacctggctgtgctgctg	3	9	17	12	2	0	0	0	0	0	0	1	1	1	0	3	5	4	5	3	5	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:206224591G>C	uc001hds.2	+	1	309	c.151G>C	c.(151-153)GGC>CGC	p.G51R		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	51	Helical; Name=1; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	GGCGACCGGGGGCAACCTGGC	0.682													21	59					0	0	0	0	C	206224591	C	C	206224591	3	2	16	1	0	0	0	0	1	0	0	0	1234	1232	43	4	153	4	AVPR1B	1	206224591	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	5270515	206224591	43026030	37	3425											
IL24	11009	broad.mit.edu	37	chr1	207072725	207072725	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagatggttgtgctcccttgCctgggttttaccctgcttct	3	16	10	12	0	1	1	0	0	1	1	2	1	2	1	3	2	4	4	3	2	1	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:207072725C>A	uc001hes.1	+	3	379	c.105C>A	c.(103-105)TGC>TGA	p.C35*	IL24_uc001het.1_Intron|IL24_uc001heu.1_Nonsense_Mutation_p.C36*|IL24_uc001hev.1_Intron|IL24_uc001hew.1_Nonsense_Mutation_p.C36*|IL24_uc001hex.1_Intron	NM_006850	NP_006841	Q13007	IL24_HUMAN	interleukin 24 isoform 1 precursor	35					apoptosis	extracellular space	cytokine activity				0	Breast(84;0.201)					TGCTCCCTTGCCTGGGTTTTA	0.592													22	46					1.1804e-14	1.54731e-14	1	0	A	207072725	A	A	207072725	4	1	16	1	0	0	0	0	0	1	0	0	7716	747	26	4	114	4	IL24	1	207072725	Nonsense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	848134	207072725	42177896	38	3426											
CR2	1380	broad.mit.edu	37	chr1	207649656	207649656	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatagctcgattttctcctGgaatgtcaatcctgtacagc	10	13	7	11	1	2	0	1	0	1	0	5	2	3	1	2	1	3	2	2	1	4	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:207649656G>A	uc001hfw.2	+	14	2711	c.2617G>A	c.(2617-2619)GGA>AGA	p.G873R	CR2_uc001hfv.2_Missense_Mutation_p.G932R|CR2_uc009xch.2_Intron	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	873	Sushi 14.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						ATTTTCTCCTGGAATGTCAAT	0.527													25	76					0	0	0	0	A	207649656	A	A	207649656	3	1	16	1	0	0	0	0	1	0	0	0	3857	1349	47	4	2852	4	CR2	1	207649656	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	576931	207649656	41600965	39	3427											
USH2A	7399	broad.mit.edu	37	chr1	215901506	215901506	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attcaacagaactgaatgagCactcgtggcttgagcccaag	13	8	10	10	1	1	4	1	3	0	1	2	4	1	4	1	1	4	2	1	1	4	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:215901506C>G	uc001hku.1	-	61	12319	c.11932G>C	c.(11932-11934)GCT>CCT	p.A3978P		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3978	Fibronectin type-III 25.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACTGAATGAGCACTCGTGGCT	0.488										HNSCC(13;0.011)			37	63					0	0	0	0	G	215901506	G	G	215901506	3	3	16	1	0	0	0	0	1	0	0	0	17104	710	25	4	3724	4	USH2A	1	215901506	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	8251850	215901506	33349115	40	3428											
USH2A	7399	broad.mit.edu	37	chr1	216019335	216019335	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaggtagcagaactccaaaaAagtgtgtaatattcaacttc	16	10	8	7	0	1	1	1	0	0	1	3	2	2	1	1	1	3	3	1	1	8	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:216019335A>T	uc001hku.1	-	45	9273	c.8886T>A	c.(8884-8886)CTT>CTA	p.L2962L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2962	Fibronectin type-III 16.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AACTCCAAAAAAGTGTGTAAT	0.398										HNSCC(13;0.011)			11	26					0	0	0	0	T	216019335	T	T	216019335	2	4	16	1	0	0	0	0	0	0	0	1	17104	1	1	5		5	USH2A	1	216019335	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	117829	216019335	33231286	41	3429											
FMN2	56776	broad.mit.edu	37	chr1	240255689	240255689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaggcgccggcggctccCgcgaagatgtactggattcc	8	6	15	12	5	0	1	0	0	0	1	2	4	2	3	3	5	1	2	3	5	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:240255689C>T	uc010pyd.1	+	1	505	c.280C>T	c.(280-282)CGC>TGC	p.R94C	FMN2_uc010pye.1_Missense_Mutation_p.R94C	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	94					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CGGCGGCTCCCGCGAAGATGT	0.622													7	14					0	0	0	0	T	240255689	T	T	240255689	3	4	16	1	0	0	0	0	1	0	0	0	5982	652	23	1	282	1	FMN2	1	240255689	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	24236354	240255689	8994932	42	3430											
FMN2	56776	broad.mit.edu	37	chr1	240601394	240601394	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acggcatatttcttcatgaaAccaaaacttggagagaagga	16	9	9	7	1	2	2	1	1	1	1	2	5	2	4	1	3	2	1	1	3	5	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:240601394A>T	uc010pyd.1	+	16	5169	c.4944A>T	c.(4942-4944)AAA>AAT	p.K1648N	FMN2_uc010pye.1_Missense_Mutation_p.K1652N|FMN2_uc010pyg.1_Missense_Mutation_p.K244N	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1648	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCTTCATGAAACCAAAACTTG	0.383													38	76					0	0	0	0	T	240601394	T	T	240601394	3	4	16	1	0	0	0	0	1	0	0	0	5982	40	2	5	5006	5	FMN2	1	240601394	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	345705	240601394	8649227	43	3431											
CEP170	9859	broad.mit.edu	37	chr1	243289810	243289810	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttgaatctattgaaatgtaTactgaaatcagcctcagatt	14	14	7	6	0	3	4	2	3	1	1	3	4	3	4	1	0	2	2	1	0	6	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:243289810T>C	uc001hzs.2	-	20	5104	c.4696A>G	c.(4696-4698)ATA>GTA	p.I1566V	CEP170_uc001hzt.2_Missense_Mutation_p.I1442V|CEP170_uc001hzu.2_Missense_Mutation_p.I1468V|CEP170_uc001hzr.2_Missense_Mutation_p.I155V|CEP170_uc001hzv.1_Intron	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1566	Targeting to microtubules.|Targeting to centrosomes.					centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TTGAAATGTATACTGAAATCA	0.438													9	16					0	0	0	0	C	243289810	C	C	243289810	3	2	16	1	0	0	0	0	1	0	0	0	3265	1406	49	5	62	5	CEP170	1	243289810	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	2688416	243289810	5960811	44	3432											
OR11L1	391189	broad.mit.edu	37	chr1	248004808	248004808	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgcatgaggaaggggtagcGgagtgggctgcagatggcca	10	6	19	6	1	0	2	0	1	0	1	0	4	0	4	1	6	3	4	1	6	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:248004808G>T	uc001idn.1	-	1	391	c.391C>A	c.(391-393)CGC>AGC	p.R131S		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AAGGGGTAGCGGAGTGGGCTG	0.587													12	29					5.50884e-06	5.9648e-06	1	0	T	248004808	T	T	248004808	3	4	16	1	0	0	0	0	1	0	0	0	10984	1116	39	3	581	3	OR11L1	1	248004808	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4714998	248004808	1245813	45	3433											
OR11L1	391189	broad.mit.edu	37	chr1	248005080	248005080	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgatgatgacaacattccctAtaatggtcaggcagtagatg	13	11	10	7	0	1	4	1	3	0	1	2	4	2	4	1	2	1	2	1	2	4	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:248005080A>G	uc001idn.1	-	1	119	c.119T>C	c.(118-120)ATA>ACA	p.I40T		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AACATTCCCTATAATGGTCAG	0.502													14	28					0	0	0	0	G	248005080	G	G	248005080	3	3	16	1	0	0	0	0	1	0	0	0	10984	449	16	5	853	5	OR11L1	1	248005080	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	272	248005080	1245541	46	3434											
OR2T11	127077	broad.mit.edu	37	chr1	248790416	248790416	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagggtgaagtcagaggatGatgtgttcgtcattgatatg	10	12	16	3	1	2	4	2	3	0	1	3	6	2	6	0	3	0	1	0	3	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:248790416G>C	uc001ier.1	-	1	14	c.14C>G	c.(13-15)TCA>TGA	p.S5*		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTCAGAGGATGATGTGTTCGT	0.547													17	44					0	0	0	0	C	248790416	C	C	248790416	4	2	16	1	0	0	0	0	0	1	0	0	11072	1294	45	2	940	2	OR2T11	1	248790416	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	785336	248790416	460205	47	3435											
OR2T27	403239	broad.mit.edu	37	chr1	248813780	248813780	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcagatcttgcggctcaTgaggacaggatagtgcagag	11	7	14	9	1	2	3	1	1	1	2	2	5	2	5	1	3	3	3	1	3	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr1:248813780T>A	uc010pzo.1	-	1	406	c.406A>T	c.(406-408)ATG>TTG	p.M136L		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGCGGCTCATGAGGACAGGA	0.557													20	48					0	0	0	0	A	248813780	A	A	248813780	3	1	16	1	0	0	0	0	1	0	0	0	11075	1464	51	5	550	5	OR2T27	1	248813780	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	23364	248813780	436841	48	3436											
TPO	7173	broad.mit.edu	37	chr2	1457542	1457542	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctatgaggacggcttcagtCagccccgaggctggaacccc	8	7	12	14	2	3	1	2	1	1	0	3	4	3	3	4	4	2	2	4	4	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:1457542C>A	uc002qww.2	+	6	650	c.559C>A	c.(559-561)CAG>AAG	p.Q187K	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.Q187K|TPO_uc002qwr.2_Missense_Mutation_p.Q187K|TPO_uc002qwx.2_Missense_Mutation_p.Q187K|TPO_uc010yio.1_Missense_Mutation_p.Q187K|TPO_uc010yip.1_Missense_Mutation_p.Q187K	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	187	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CGGCTTCAGTCAGCCCCGAGG	0.602													29	60					7.41945e-09	8.63134e-09	1	0	A	1457542	A	A	1457542	3	1	16	1	0	0	0	0	1	0	0	0	16477	827	29	2	577	2	TPO	2	1457542	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08		1457542	241741831	49	3437											
PXDN	7837	broad.mit.edu	37	chr2	1684055	1684055	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccgctgcctgcgcgttccCcgactccgcgtaggttttca	3	10	12	16	6	1	0	1	0	0	0	3	1	3	0	5	2	2	4	5	2	1	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:1684055C>G	uc002qxa.2	-	7	704	c.640G>C	c.(640-642)GGG>CGG	p.G214R	PXDN_uc002qxb.1_Missense_Mutation_p.G214R|PXDN_uc002qxc.1_Missense_Mutation_p.G31R	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	214	LRRCT.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TGCGCGTTCCCCGACTCCGCG	0.582													11	24					0	0	0	0	G	1684055	G	G	1684055	3	3	16	1	0	0	0	0	1	0	0	0	12912	623	22	4	3867	4	PXDN	2	1684055	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	226513	1684055	241515318	50	3438											
ATP6V1C2	245973	broad.mit.edu	37	chr2	10923308	10923308	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttcttttgtaggcatctgtGgagatcccgggactgcaact	7	13	11	10	1	2	1	0	0	2	1	3	3	3	2	1	3	2	3	1	3	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:10923308G>A	uc002ras.2	+	14	1312	c.1203G>A	c.(1201-1203)GTG>GTA	p.V401V	ATP6V1C2_uc002rat.2_Silent_p.V355V	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	vacuolar H+ ATPase C2 isoform a	401					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		AGGCATCTGTGGAGATCCCGG	0.443													20	45					0	0	0	0	A	10923308	A	A	10923308	2	1	16	1	0	0	0	0	0	0	0	1	1183	1335	47	4		4	ATP6V1C2	2	10923308	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	9239253	10923308	232276065	51	3439											
APOB	338	broad.mit.edu	37	chr2	21231404	21231404	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtttgctgaggtggttccaTtccctatgtcagcatttgca	6	15	10	10	1	1	1	1	1	0	0	3	1	3	1	2	2	3	5	2	2	1	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:21231404T>A	uc002red.2	-	26	8464	c.8336A>T	c.(8335-8337)AAT>ATT	p.N2779I		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2779					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGTGGTTCCATTCCCTATGTC	0.398													40	65					0	0	0	0	A	21231404	A	A	21231404	3	1	16	1	0	0	0	0	1	0	0	0	785	1493	52	5	5371	5	APOB	2	21231404	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	10308096	21231404	221967969	52	3440											
XDH	7498	broad.mit.edu	37	chr2	31598392	31598392	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgccagtcctgcacacaCgtcctgcagcagctcctcct	6	9	7	19	1	1	0	0	0	1	0	5	0	5	0	5	0	5	4	5	0	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:31598392C>A	uc002rnv.1	-	15	1535	c.1456G>T	c.(1456-1458)GTG>TTG	p.V486L		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	486					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CCTGCACACACGTCCTGCAGC	0.637													18	26					1.67942e-08	1.93616e-08	1	0	A	31598392	A	A	31598392	3	1	16	1	0	0	0	0	1	0	0	0	17494	536	19	3	2633	3	XDH	2	31598392	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	10366988	31598392	211600981	53	3441											
THUMPD2	80745	broad.mit.edu	37	chr2	39971589	39971589	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggaatgtcagaaataataaTatcaacactttctgaaggca	17	11	7	6	0	3	2	2	1	1	1	3	3	3	3	0	2	1	1	0	2	7	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:39971589T>C	uc002rru.2	-	9	1145	c.1108A>G	c.(1108-1110)ATT>GTT	p.I370V	THUMPD2_uc002rrv.2_RNA|THUMPD2_uc010ynt.1_Missense_Mutation_p.I261V	NM_025264	NP_079540	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	370							methyltransferase activity			skin(1)	1		all_hematologic(82;0.248)				GAAATAATAATATCAACACTT	0.279													16	30					0	0	0	0	C	39971589	C	C	39971589	3	2	16	1	0	0	0	0	1	0	0	0	15949	1406	49	5	411	5	THUMPD2	2	39971589	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	8373197	39971589	203227784	54	3442											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48848069	48848069	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagaaggtatagaggaacAagttttaaaagacttgaagc	18	9	11	3	0	0	5	0	2	0	3	0	6	0	6	0	2	2	2	0	2	9	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:48848069A>G	uc010yol.1	+	3	2260	c.2213A>G	c.(2212-2214)CAA>CGA	p.Q738R	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.Q738R|GTF2A1L_uc002rws.1_Missense_Mutation_p.Q34R|GTF2A1L_uc010yom.1_Intron|GTF2A1L_uc002rwt.2_Missense_Mutation_p.Q34R	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	738					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATAGAGGAACAAGTTTTAAAA	0.333													18	31					0	0	0	0	G	48848069	G	G	48848069	3	3	16	1	0	0	0	0	1	0	0	0	15383	130	5	5	2223	5	STON1-GTF2A1L	2	48848069	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	8876480	48848069	194351304	55	3443											
NRXN1	9378	broad.mit.edu	37	chr2	51254950	51254950	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccgggggcagccccccgacGaaaaggccgctgaacaccgt	9	3	13	16	5	0	1	0	1	0	0	1	3	1	1	6	3	2	2	6	3	3	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:51254950G>A	uc010fbq.2	-	2	1939	c.462C>T	c.(460-462)TTC>TTT	p.F154F	NRXN1_uc002rxe.3_Silent_p.F154F|NRXN1_uc002rxd.1_Silent_p.F154F	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCCCCCCGACGAAAAGGCCGC	0.662													5	21					0	0	0	0	A	51254950	A	A	51254950	2	1	16	1	0	0	0	0	0	0	0	1	10719	1049	37	1		1	NRXN1	2	51254950	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2406881	51254950	191944423	56	3444											
CNRIP1	25927	broad.mit.edu	37	chr2	68521024	68521024	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactccttgttcacccacatCagactgcgtgtctcgttggg	6	12	10	13	2	3	1	2	0	1	1	5	2	4	1	2	1	1	2	2	1	0	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:68521024C>A	uc002sek.3	-	3	1116	c.465G>T	c.(463-465)CTG>CTT	p.L155L	CNRIP1_uc002sej.3_Intron|CNRIP1_uc002sem.1_RNA|CNRIP1_uc002sel.3_RNA	NM_015463	NP_056278	Q96F85	CNRP1_HUMAN	cannabinoid receptor interacting protein 1	155							protein binding			liver(1)	1						TCACCCACATCAGACTGCGTG	0.473													25	40					2.79863e-10	3.35941e-10	1	0	A	68521024	A	A	68521024	2	1	16	1	0	0	0	0	0	0	0	1	3648	813	29	2		2	CNRIP1	2	68521024	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	17266074	68521024	174678349	57	3445											
DYSF	8291	broad.mit.edu	37	chr2	71839829	71839829	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcaaggtcatcgataaccGccagtttggccgccggcctg	7	8	12	14	5	2	0	2	0	0	0	3	1	2	0	5	3	1	1	5	3	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:71839829G>T	uc002sie.2	+	39	4602	c.4226G>T	c.(4225-4227)CGC>CTC	p.R1409L	DYSF_uc010feg.2_Missense_Mutation_p.R1440L|DYSF_uc010feh.2_Missense_Mutation_p.R1395L|DYSF_uc002sig.3_Missense_Mutation_p.R1395L|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R1409L|DYSF_uc010fef.2_Missense_Mutation_p.R1426L|DYSF_uc010fei.2_Missense_Mutation_p.R1426L|DYSF_uc010fek.2_Missense_Mutation_p.R1427L|DYSF_uc010fej.2_Missense_Mutation_p.R1396L|DYSF_uc010fel.2_Missense_Mutation_p.R1396L|DYSF_uc010feo.2_Missense_Mutation_p.R1441L|DYSF_uc010fem.2_Missense_Mutation_p.R1410L|DYSF_uc010fen.2_Missense_Mutation_p.R1427L|DYSF_uc002sif.2_Missense_Mutation_p.R1410L|DYSF_uc010yqy.1_Missense_Mutation_p.R290L|DYSF_uc010yqz.1_Missense_Mutation_p.R149L	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1409	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						ATCGATAACCGCCAGTTTGGC	0.637													23	52					2.41591e-17	3.27399e-17	1	0	T	71839829	T	T	71839829	3	4	16	1	0	0	0	0	1	0	0	0	4881	1087	38	3	4572	3	DYSF	2	71839829	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3318805	71839829	171359544	58	3446											
REG3G	130120	broad.mit.edu	37	chr2	79254295	79254295	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgggctccatgaccccacaCaggtgcgagtatatcctccc	8	9	9	15	1	0	1	0	1	0	0	3	2	3	1	5	2	1	2	5	2	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:79254295C>A	uc002snw.2	+	4	416	c.331C>A	c.(331-333)CAG>AAG	p.Q111K	REG3G_uc002snx.2_Missense_Mutation_p.Q111K|REG3G_uc010ffu.2_Intron	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	111	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						TGACCCCACACAGGTGCGAGT	0.557													33	67					3.76114e-14	4.88034e-14	1	0	A	79254295	A	A	79254295	3	1	16	1	0	0	0	0	1	0	0	0	13278	479	17	4	341	4	REG3G	2	79254295	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	7414466	79254295	163945078	59	3447											
LRRTM1	347730	broad.mit.edu	37	chr2	80529964	80529964	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctggaagttgttgagccaCgaggctagggcacacacgtt	9	8	13	11	2	0	1	0	1	0	0	0	3	0	2	2	3	1	5	2	3	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:80529964C>T	uc002sok.1	-	2	1251	c.981G>A	c.(979-981)TCG>TCA	p.S327S	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	327	LRRCT.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						TGTTGAGCCACGAGGCTAGGG	0.637										HNSCC(69;0.2)			7	17					0	0	0	0	T	80529964	T	T	80529964	2	4	16	1	0	0	0	0	0	0	0	1	9089	523	19	1		1	LRRTM1	2	80529964	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1275669	80529964	162669409	60	3448											
SMYD1	150572	broad.mit.edu	37	chr2	88405918	88405918	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	accaacatctacatgctgcgGatgctgagcattgtttcgga	10	11	10	10	2	1	1	0	1	1	0	2	3	1	3	1	2	6	4	1	2	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:88405918G>C	uc002ssr.2	+	8	1058	c.1056G>C	c.(1054-1056)CGG>CGC	p.R352R	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Silent_p.R48R	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						ACATGCTGCGGATGCTGAGCA	0.547													22	41					0	0	0	0	C	88405918	C	C	88405918	2	2	16	1	0	0	0	0	0	0	0	1	14885	1161	41	2		2	SMYD1	2	88405918	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	7875954	88405918	154793455	61	3449											
CNGA3	1261	broad.mit.edu	37	chr2	98999860	98999860	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccttcccgcagcgcctggccCctggccaaatgcaacactaa	9	6	8	18	2	0	0	0	0	0	0	1	0	1	0	6	2	3	2	6	2	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:98999860C>T	uc002syt.2	+	5	822	c.405C>T	c.(403-405)CCC>CCT	p.P135P	CNGA3_uc002syu.2_Intron|CNGA3_uc010fij.2_Silent_p.P139P	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	135					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						GCGCCTGGCCCCTGGCCAAAT	0.597													9	39					0	0	0	0	T	98999860	T	T	98999860	2	4	16	1	0	0	0	0	0	0	0	1	3613	610	22	4		4	CNGA3	2	98999860	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	10593942	98999860	144199513	62	3450											
C2orf55	343990	broad.mit.edu	37	chr2	99439551	99439551	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacgggctcgcgacgtcttcGggagcacagaccacctcctc	8	6	11	16	5	1	1	0	0	1	1	5	3	2	2	3	2	2	2	3	2	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:99439551G>T	uc002szf.1	-	7	1479	c.1185C>A	c.(1183-1185)CCC>CCA	p.P395P		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	395	Pro-rich.										0						CGACGTCTTCGGGAGCACAGA	0.731													8	11					0.00448238	0.00461189	1	0	T	99439551	T	T	99439551	2	4	16	1	0	0	0	0	0	0	0	1	2186	1103	39	3		3	C2orf55	2	99439551	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	439691	99439551	143759822	63	3451											
IL1R1	3554	broad.mit.edu	37	chr2	102788275	102788275	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgcaggatcccagatacaaTtgatctgtaatgtcaccggc	11	11	9	10	1	2	2	1	1	1	1	3	3	3	3	2	2	2	2	2	2	3	4	rs35308674	byFrequency	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:102788275T>A	uc002tbq.2	+	8	1054	c.736T>A	c.(736-738)TTG>ATG	p.L246M	IL1R1_uc010fix.2_Missense_Mutation_p.L246M|IL1R1_uc002tbp.2_Missense_Mutation_p.L246M|IL1R1_uc002tbr.2_Missense_Mutation_p.L246M	NM_000877	NP_000868	P14778	IL1R1_HUMAN	interleukin 1 receptor, type I precursor	246	Ig-like C2-type 3.|Extracellular (Potential).				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			skin(1)	1					Anakinra(DB00026)	CCAGATACAATTGATCTGTAA	0.294													10	33					0	0	0	0	A	102788275	A	A	102788275	3	1	16	1	0	0	0	0	1	0	0	0	7697	1490	52	5	758	5	IL1R1	2	102788275	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	3348724	102788275	140411098	64	3452											
SLC5A7	60482	broad.mit.edu	37	chr2	108626897	108626897	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgtggcaggttatgtttcTggcctcttcctgagaataac	7	13	11	10	1	2	1	0	1	2	1	3	2	3	1	3	3	1	3	3	3	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:108626897T>A	uc002tdv.2	+	9	1599	c.1323T>A	c.(1321-1323)TCT>TCA	p.S441S	SLC5A7_uc010ywm.1_Silent_p.S194S|SLC5A7_uc010fjj.2_Silent_p.S441S|SLC5A7_uc010ywn.1_Silent_p.S328S	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	441	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GTTATGTTTCTGGCCTCTTCC	0.453													16	49					0	0	0	0	A	108626897	A	A	108626897	2	1	16	1	0	0	0	0	0	0	0	1	14734	1567	55	5		5	SLC5A7	2	108626897	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	5838622	108626897	134572476	65	3453											
PSD4	23550	broad.mit.edu	37	chr2	113955162	113955163	+	Missense_Mutation	DNP	GG	TT	TT																															gccatggggcaagcgtggctGgaagatgttccacaccttac																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:113955162_113955163GG>TT	uc002tjc.2	+	13	2591_2592	c.2408_2409GG>TT	c.(2407-2409)TGG>TTT	p.W803F	PSD4_uc002tjd.2_Missense_Mutation_p.W424F|PSD4_uc002tje.2_Missense_Mutation_p.W774F|PSD4_uc002tjf.2_Missense_Mutation_p.W424F|PSD4_uc002tjg.2_5'UTR|PSD4_uc010yxs.1_Missense_Mutation_p.W34F|PSD4_uc002tjh.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	803	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						AAGCGTGGCTGGAAGATGTTCC	0.55													6	25					0	0	0	0	TT	113955163	TT	TT	113955162	3	4	16	1	0	0	0	0	1	0	0	0	12711	1357	47	4	2454	4	PSD4	2	113955162	Missense_Mutation	DNP	GG	TCGA-BA-6869-01A-11D-1870-08	5328265	113955162	129244211	66	3454											
THSD7B	80731	broad.mit.edu	37	chr2	138320906	138320906	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgcgctgtggaggaggaaCacaatctaggaaaatcaggt	13	7	13	8	1	2	0	1	0	1	0	2	4	2	4	1	5	2	1	1	5	5	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:138320906C>A	uc002tva.1	+	15	3167	c.3167C>A	c.(3166-3168)ACA>AAA	p.T1056K	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGAGGAGGAACACAATCTAGG	0.413													14	30					2.31682e-05	2.46692e-05	1	0	A	138320906	A	A	138320906	3	1	16	1	0	0	0	0	1	0	0	0	15946	478	17	4	3224	4	THSD7B	2	138320906	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	24365744	138320906	104878467	67	3455											
LRP1B	53353	broad.mit.edu	37	chr2	141092122	141092122	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccccaacaacagtccagtaCatcatcctgaagagagcggg	13	6	9	13	1	1	2	1	1	0	1	4	3	4	2	4	1	4	1	4	1	4	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:141092122C>A	uc002tvj.1	-	79	13095	c.12123G>T	c.(12121-12123)ATG>ATT	p.M4041I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4041	Extracellular (Potential).|LDL-receptor class B 35.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTCCAGTACATCATCCTGA	0.383										TSP Lung(27;0.18)			18	41					1.67942e-08	1.93616e-08	1	0	A	141092122	A	A	141092122	3	1	16	1	0	0	0	0	1	0	0	0	9005	478	17	4	1728	4	LRP1B	2	141092122	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2771216	141092122	102107251	68	3456											
LRP1B	53353	broad.mit.edu	37	chr2	141108566	141108566	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggatatataaaacccaggaTatcagtgtcattagcaatgt	15	12	8	6	0	2	0	2	0	0	0	2	2	2	2	1	2	2	1	1	2	7	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:141108566T>A	uc002tvj.1	-	77	12664	c.11692A>T	c.(11692-11694)ATC>TTC	p.I3898F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3898	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAACCCAGGATATCAGTGTCA	0.284										TSP Lung(27;0.18)			35	91					0	0	0	0	A	141108566	A	A	141108566	3	1	16	1	0	0	0	0	1	0	0	0	9005	1406	49	5	2167	5	LRP1B	2	141108566	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	16444	141108566	102090807	69	3457											
LRP1B	53353	broad.mit.edu	37	chr2	141208166	141208166	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggttcatcagatccatcaCcacagtcatccacggtgtca	11	9	7	14	1	5	1	5	0	0	1	7	1	7	1	3	2	0	1	3	2	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:141208166C>G	uc002tvj.1	-	63	11000	c.10028G>C	c.(10027-10029)GGT>GCT	p.G3343A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3343	Extracellular (Potential).|LDL-receptor class A 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGATCCATCACCACAGTCATC	0.348										TSP Lung(27;0.18)			19	65					0	0	0	0	G	141208166	G	G	141208166	3	3	16	1	0	0	0	0	1	0	0	0	9005	507	18	4	3887	4	LRP1B	2	141208166	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	99600	141208166	101991207	70	3458											
NEB	4703	broad.mit.edu	37	chr2	152563504	152563504	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttttcatagtcttctttgTattttacctgtaggagtgaa	8	20	7	6	0	4	1	1	1	3	0	4	2	4	2	1	1	1	2	1	1	5	9			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:152563504T>C	uc010fnx.2	-	13	1234	c.1043A>G	c.(1042-1044)TAC>TGC	p.Y348C	NEB_uc010fny.1_Translation_Start_Site	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	348	Nebulin 8.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTCTTCTTTGTATTTTACCTG	0.373													5	11					0	0	0	0	C	152563504	C	C	152563504	3	2	16	1	0	0	0	0	1	0	0	0	10356	1638	57	5	25323	5	NEB	2	152563504	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	11355338	152563504	90635869	71	3459											
FIGN	55137	broad.mit.edu	37	chr2	164467533	164467533	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggcaggtacgctgaaggcGgaggcggtgcccccccaggg	8	3	18	12	3	0	1	0	1	0	0	0	2	0	2	3	7	2	3	3	7	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:164467533G>T	uc002uck.1	-	3	1120	c.809C>A	c.(808-810)CCG>CAG	p.P270Q		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	270	Pro-rich.					nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CGCTGAAGGCGGAGGCGGTGC	0.592													19	35					7.45023e-12	9.30915e-12	1	0	T	164467533	T	T	164467533	3	4	16	1	0	0	0	0	1	0	0	0	5923	1116	39	3	1474	3	FIGN	2	164467533	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	11904029	164467533	78731840	72	3460											
SCN1A	6323	broad.mit.edu	37	chr2	166850763	166850763	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactctccagtaaatagcAcaatgaacaccagattgatg	16	8	6	11	0	1	3	0	2	1	1	2	3	1	3	2	0	2	2	2	0	5	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:166850763A>G	uc010zcz.1	-	25	4730	c.4712T>C	c.(4711-4713)GTG>GCG	p.V1571A		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1582	Helical; Name=S2 of repeat IV; (By similarity).|IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGTAAATAGCACAATGAACAC	0.378													12	33					0	0	0	0	G	166850763	G	G	166850763	3	3	16	1	0	0	0	0	1	0	0	0	13979	159	6	5	1292	5	SCN1A	2	166850763	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	2383230	166850763	76348610	73	3461											
SCN9A	6335	broad.mit.edu	37	chr2	167056252	167056253	+	Missense_Mutation	DNP	GC	TG	TG																															catcatcaaagcaaagagcaGcgtgcggatcccctttgctc																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:167056252_167056253GC>TG	uc010fpl.2	-	27	5204_5205	c.4863_4864GC>CA	c.(4861-4866)ACGCTG>ACCATG	p.L1622M	uc002udp.2_RNA	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1633	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GCAAAGAGCAGCGTGCGGATCC	0.5													54	109					0	0	0	0	TG	167056253	TG	TG	167056252	3	4	16	1	0	0	0	0	1	0	0	0	13990	962	34	4	1073	4	SCN9A	2	167056252	Missense_Mutation	DNP	GC	TCGA-BA-6869-01A-11D-1870-08	205489	167056252	76143121	74	3462											
XIRP2	129446	broad.mit.edu	37	chr2	168099600	168099600	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaaagagaatacttggaatgGgatgaaattctgaagggaga	17	8	14	2	0	1	4	0	2	1	2	1	9	1	6	0	3	1	0	0	3	6	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:168099600G>T	uc002udx.2	+	8	1716	c.1698G>T	c.(1696-1698)TGG>TGT	p.W566C	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.W391C|XIRP2_uc010fpq.2_Missense_Mutation_p.W344C|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	391					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ACTTGGAATGGGATGAAATTC	0.403													13	25					1.49906e-05	1.60417e-05	1	0	T	168099600	T	T	168099600	3	4	16	1	0	0	0	0	1	0	0	0	17498	1241	43	4	1728	4	XIRP2	2	168099600	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1043348	168099600	75099773	75	3463											
AGPS	8540	broad.mit.edu	37	chr2	178301756	178301756	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggaaggaatgtttgagcGaattcctgatatagttttat	12	14	11	4	1	0	2	0	2	0	0	1	5	1	4	1	2	1	2	1	2	6	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:178301756G>T	uc002ull.2	+	5	658	c.611G>T	c.(610-612)CGA>CTA	p.R204L	AGPS_uc010zfb.1_Missense_Mutation_p.R114L	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	204	FAD-binding PCMH-type.				ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity	p.R204R(1)		ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			ATGTTTGAGCGAATTCCTGAT	0.303													30	72					3.67414e-24	5.30433e-24	1	0	T	178301756	T	T	178301756	3	4	16	1	0	0	0	0	1	0	0	0	394	1058	37	3	629	3	AGPS	2	178301756	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	10202156	178301756	64897617	76	3464											
TTN	7273	broad.mit.edu	37	chr2	179481873	179481873	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catcgtcagcggtgagaggaCcaagaatttcagatggatct	12	9	12	8	2	3	3	2	1	1	3	4	6	3	5	1	3	1	0	1	3	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:179481873C>A	uc010zfg.1	-	204	40369	c.40145G>T	c.(40144-40146)GGT>GTT	p.G13382V	TTN_uc010zfh.1_Missense_Mutation_p.G7077V|TTN_uc010zfi.1_Missense_Mutation_p.G7010V|TTN_uc010zfj.1_Missense_Mutation_p.G6885V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14309							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGAGAGGACCAAGAATTTC	0.368													7	18					1.12685e-05	1.21397e-05	1	0	A	179481873	A	A	179481873	3	1	16	1	0	0	0	0	1	0	0	0	16803	507	18	4	60276	4	TTN	2	179481873	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1180117	179481873	63717500	77	3465											
TTN	7273	broad.mit.edu	37	chr2	179577472	179577472	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccttgccagcttcattgcTaactatgcaagtatattctc	10	14	6	11	0	2	0	1	0	1	0	3	0	2	0	2	0	6	4	2	0	5	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:179577472T>A	uc010zfg.1	-	91	23772	c.23548A>T	c.(23548-23550)AGC>TGC	p.S7850C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S4511C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8777							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCATTGCTAACTATGCAA	0.393													25	69					0	0	0	0	A	179577472	A	A	179577472	3	1	16	1	0	0	0	0	1	0	0	0	16803	1522	53	5	77325	5	TTN	2	179577472	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	95599	179577472	63621901	78	3466											
CWC22	57703	broad.mit.edu	37	chr2	180835757	180835757	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacgctatcatctgttggtCtttccaggagcaaagtgagc	10	11	10	10	1	3	1	1	1	2	0	4	2	4	2	1	2	3	3	1	2	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:180835757C>G	uc010frh.1	-	9	1151	c.851G>C	c.(850-852)AGA>ACA	p.R284T	CWC22_uc002unp.2_Missense_Mutation_p.R284T	NM_020943	NP_065994	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog	284	MIF4G.					catalytic step 2 spliceosome	protein binding|RNA binding				0						ATCTGTTGGTCTTTCCAGGAG	0.353													16	22					0	0	0	0	G	180835757	G	G	180835757	3	3	16	1	0	0	0	0	1	0	0	0	4085	913	32	2	1923	2	CWC22	2	180835757	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1258285	180835757	62363616	79	3467											
CWC22	57703	broad.mit.edu	37	chr2	180851515	180851515	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aatctctatcccggggggatCgttcttgttcttcatatcta	7	16	8	10	2	5	0	1	0	4	0	8	1	6	1	1	3	0	2	1	3	4	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:180851515C>G	uc010frh.1	-	4	413	c.113G>C	c.(112-114)CGA>CCA	p.R38P	CWC22_uc002unp.2_Missense_Mutation_p.R38P	NM_020943	NP_065994	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog	38	Arg-rich.					catalytic step 2 spliceosome	protein binding|RNA binding				0						CCGGGGGGATCGTTCTTGTTC	0.343													18	17					0	0	0	0	G	180851515	G	G	180851515	3	3	16	1	0	0	0	0	1	0	0	0	4085	884	31	3	2681	3	CWC22	2	180851515	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	15758	180851515	62347858	80	3468											
SLC39A10	57181	broad.mit.edu	37	chr2	196581405	196581405	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagatcgacttaatgaaactGaactgacagatttagaaggc	17	9	9	6	1	0	6	0	3	0	3	1	7	0	6	0	1	2	0	0	1	6	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:196581405G>A	uc002utg.3	+	7	1955	c.1741G>A	c.(1741-1743)GAA>AAA	p.E581K	SLC39A10_uc002uth.3_Missense_Mutation_p.E581K|SLC39A10_uc010zgp.1_Missense_Mutation_p.E131K	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	581					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TAATGAAACTGAACTGACAGA	0.348													20	33					0	0	0	0	A	196581405	A	A	196581405	3	1	16	1	0	0	0	0	1	0	0	0	14677	1291	45	2	1763	2	SLC39A10	2	196581405	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	15729890	196581405	46617968	81	3469											
DNAH7	56171	broad.mit.edu	37	chr2	196659141	196659142	+	Missense_Mutation	DNP	CC	TA	TA																															gaatgatattagcccgtaaaCcttttggtgcttcattggtc																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:196659141_196659142CC>TA	uc002utj.3	-	57	10737_10738	c.10636_10637GG>TA	c.(10636-10638)GGT>TAT	p.G3546Y	DNAH7_uc002uti.3_Missense_Mutation_p.G29Y	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3546	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGCCCGTAAACCTTTTGGTGCT	0.441													35	83					0	0	0	0	TA	196659142	TA	TA	196659141	3	4	16	1	0	0	0	0	1	0	0	0	4628	507	18	4	1473	4	DNAH7	2	196659141	Missense_Mutation	DNP	CC	TCGA-BA-6869-01A-11D-1870-08	77736	196659141	46540232	82	3470											
DNAH7	56171	broad.mit.edu	37	chr2	196674504	196674504	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtagatttatggttagacAaaaggaaaagagcagcttat	17	10	10	4	0	0	3	0	0	0	3	0	4	0	4	0	2	2	4	0	2	8	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:196674504A>C	uc002utj.3	-	52	9954	c.9853T>G	c.(9853-9855)TGT>GGT	p.C3285G		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3285					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATGGTTAGACAAAAGGAAAAG	0.368													19	31					0	0	0	0	C	196674504	C	C	196674504	3	2	16	1	0	0	0	0	1	0	0	0	4628	130	5	5	2277	5	DNAH7	2	196674504	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	15363	196674504	46524869	83	3471											
HECW2	57520	broad.mit.edu	37	chr2	197092955	197092955	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataccaggaagaaaaactctCtagaaggcccactgtaatcc	16	7	7	11	0	1	2	0	0	1	2	3	3	2	3	3	2	2	1	3	2	7	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:197092955C>A	uc002utm.1	-	22	3971	c.3788G>T	c.(3787-3789)AGA>ATA	p.R1263I	HECW2_uc002utl.1_Missense_Mutation_p.R907I	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1263	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GAAAAACTCTCTAGAAGGCCC	0.363													20	29					8.10497e-08	9.17895e-08	1	0	A	197092955	A	A	197092955	3	1	16	1	0	0	0	0	1	0	0	0	7082	913	32	2	962	2	HECW2	2	197092955	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	418451	197092955	46106418	84	3472											
FZD7	8324	broad.mit.edu	37	chr2	202900651	202900651	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcggggcttcgtgctggcGcctctgttcgtctacctctt	1	14	12	14	4	3	0	0	0	3	0	5	0	3	0	2	3	3	3	2	3	1	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:202900651G>A	uc002uyw.1	+	1	1342	c.1281G>A	c.(1279-1281)GCG>GCA	p.A427A		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	427	Helical; Name=5; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						TCGTGCTGGCGCCTCTGTTCG	0.617											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	78					0	0	0	0	A	202900651	A	A	202900651	2	1	16	1	0	0	0	0	0	0	0	1	6169	1074	38	1		1	FZD7	2	202900651	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	5807696	202900651	40298722	85	3473											
FZD5	7855	broad.mit.edu	37	chr2	208632914	208632914	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcacacgaacgggcccccagCggggcattcgccccccgagg	7	2	14	18	5	0	0	0	0	0	0	1	2	0	0	5	4	2	2	5	4	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:208632914C>A	uc002vcj.2	-	2	960	c.550G>T	c.(550-552)GCT>TCT	p.A184S		NM_003468	NP_003459	Q13467	FZD5_HUMAN	frizzled 5 precursor	184	Extracellular (Potential).				angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			ovary(2)|lung(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		GGGCCCCCAGCGGGGCATTCG	0.711													12	11					4.36969e-10	5.21596e-10	1	0	A	208632914	A	A	208632914	3	1	16	1	0	0	0	0	1	0	0	0	6167	768	27	3	1211	3	FZD5	2	208632914	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	5732263	208632914	34566459	86	3474											
CUL3	8452	broad.mit.edu	37	chr2	225371641	225371641	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagctttaccttgctccctCaaataggaactcatacactc	12	11	5	13	0	2	1	2	0	0	1	4	2	3	2	2	1	5	2	2	1	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:225371641C>G	uc002vny.2	-	7	1347	c.963G>C	c.(961-963)TTG>TTC	p.L321F	CUL3_uc010zls.1_Missense_Mutation_p.L255F|CUL3_uc010fwy.1_Missense_Mutation_p.L327F	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	321					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		CTTGCTCCCTCAAATAGGAAC	0.378													26	36					0	0	0	0	G	225371641	G	G	225371641	3	3	16	1	0	0	0	0	1	0	0	0	4073	825	29	2	1383	2	CUL3	2	225371641	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	16738727	225371641	17827732	87	3475											
SLC19A3	80704	broad.mit.edu	37	chr2	228563910	228563910	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacagaggccaaggatatgAcgttgaggtaaaagtacgac	16	6	13	6	2	0	4	0	2	0	2	0	6	0	5	1	3	1	3	1	3	5	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:228563910A>T	uc002vpi.2	-	3	610	c.521T>A	c.(520-522)GTC>GAC	p.V174D	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.V170D	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	174	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	CAAGGATATGACGTTGAGGTA	0.507													27	85					0	0	0	0	T	228563910	T	T	228563910	3	4	16	1	0	0	0	0	1	0	0	0	14495	275	10	5	985	5	SLC19A3	2	228563910	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	3192269	228563910	14635463	88	3476											
SPHKAP	80309	broad.mit.edu	37	chr2	228890142	228890142	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatctgcctggagatttcCagaggctaacccacttagga	13	9	9	10	0	1	2	0	0	1	2	2	4	2	3	3	3	2	1	3	3	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:228890142C>T	uc002vpq.2	-	5	456	c.409G>A	c.(409-411)GGA>AGA	p.G137R	SPHKAP_uc002vpp.2_Missense_Mutation_p.G137R|SPHKAP_uc010zlx.1_Missense_Mutation_p.G137R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	137						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGGAGATTTCCAGAGGCTAAC	0.378													19	60					0	0	0	0	T	228890142	T	T	228890142	3	4	16	1	0	0	0	0	1	0	0	0	15114	603	21	4	4725	4	SPHKAP	2	228890142	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	326232	228890142	14309231	89	3477											
TRIP12	9320	broad.mit.edu	37	chr2	230652349	230652349	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttacataaaaaagcatttGccgggtatcaaaaggaaaga	19	8	9	5	1	1	1	1	0	0	1	1	2	1	2	1	2	3	3	1	2	8	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:230652349G>A	uc002vpw.1	-	32	4751	c.4642C>T	c.(4642-4644)CAA>TAA	p.Q1548*	TRIP12_uc002vpx.1_Nonsense_Mutation_p.Q1596*|TRIP12_uc002vpy.1_Nonsense_Mutation_p.Q1278*	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1548	K-box.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		AAAAGCATTTGCCGGGTATCA	0.353													14	31					0	0	0	0	A	230652349	A	A	230652349	4	1	16	1	0	0	0	0	0	1	0	0	16623	1328	46	4	1376	4	TRIP12	2	230652349	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1762207	230652349	12547024	90	3478											
COL6A3	1293	broad.mit.edu	37	chr2	238277511	238277511	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtcttctatgcgactccccGcagacttaacaaagaggttt	10	11	8	12	3	2	2	0	0	2	2	3	3	3	2	2	1	2	2	2	1	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:238277511G>T	uc002vwl.2	-	10	4880	c.4595C>A	c.(4594-4596)GCG>GAG	p.A1532E	COL6A3_uc002vwo.2_Missense_Mutation_p.A1326E|COL6A3_uc010znj.1_Missense_Mutation_p.A925E	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1532	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCGACTCCCCGCAGACTTAAC	0.597													34	46					3.90053e-15	5.15513e-15	1	0	T	238277511	T	T	238277511	3	4	16	1	0	0	0	0	1	0	0	0	3716	1087	38	3	5078	3	COL6A3	2	238277511	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	7625162	238277511	4921862	91	3479											
GAL3ST2	64090	broad.mit.edu	37	chr2	242741244	242741244	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccggtcaccaacatcatgttCctgaagacgcacaagacggc	12	6	9	14	3	2	3	2	1	0	2	3	3	3	3	3	2	1	2	3	2	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr2:242741244C>T	uc002wcj.1	+	3	299	c.168C>T	c.(166-168)TTC>TTT	p.F56F		NM_022134	NP_071417	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	56	Lumenal (Potential).				biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		ACATCATGTTCCTGAAGACGC	0.662													18	33					0	0	0	0	T	242741244	T	T	242741244	2	4	16	1	0	0	0	0	0	0	0	1	6233	854	30	2		2	GAL3ST2	2	242741244	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4463733	242741244	458129	92	3480											
PLCL2	23228	broad.mit.edu	37	chr3	17052928	17052928	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatttttggaaatgtggttGccaaattgtagccatgaact	12	14	10	5	0	0	2	0	1	0	1	0	3	0	3	2	2	3	2	2	2	4	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:17052928G>C	uc011awc.1	+	5	2171	c.2066G>C	c.(2065-2067)TGC>TCC	p.C689S	PLCL2_uc011awd.1_Missense_Mutation_p.C571S	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	697	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						AAATGTGGTTGCCAAATTGTA	0.418													29	31					0	0	0	0	C	17052928	C	C	17052928	3	2	16	1	0	0	0	0	1	0	0	0	12095	1319	46	4	2090	4	PLCL2	3	17052928	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08		17052928	180969502	93	3481											
LYZL4	131375	broad.mit.edu	37	chr3	42445602	42445602	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttaattgtcttctctaaatTaggattcagtaaagctgtgg	11	17	8	5	0	3	0	1	0	2	0	4	1	3	1	0	2	1	2	0	2	6	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:42445602T>C	uc003cle.2	-	4	556	c.307A>G	c.(307-309)AAT>GAT	p.N103D		NM_144634	NP_653235	Q96KX0	LYZL4_HUMAN	lysozyme-like 4 precursor	103					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			central_nervous_system(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.222)		TTCTCTAAATTAGGATTCAGT	0.388													18	15					0	0	0	0	C	42445602	C	C	42445602	3	2	16	1	0	0	0	0	1	0	0	0	9184	1754	61	5	141	5	LYZL4	3	42445602	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	25392674	42445602	155576828	94	3482											
CCBP2	1238	broad.mit.edu	37	chr3	42906247	42906247	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcggatggttgagatctatCtgctgaatctggccatctcc	7	12	12	10	1	4	2	0	2	4	1	5	4	4	3	2	4	1	2	2	4	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:42906247C>G	uc003cme.2	+	3	432	c.253C>G	c.(253-255)CTG>GTG	p.L85V	CCBP2_uc003cmd.1_Missense_Mutation_p.L85V|CCBP2_uc003cmf.2_Missense_Mutation_p.L85V|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	85	Cytoplasmic (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		TGAGATCTATCTGCTGAATCT	0.537													53	51					0	0	0	0	G	42906247	G	G	42906247	3	3	16	1	0	0	0	0	1	0	0	0	2746	912	32	2	255	2	CCBP2	3	42906247	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	460645	42906247	155116183	95	3483											
C3orf23	285343	broad.mit.edu	37	chr3	44449031	44449031	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcatttctagtatacaaatgGtggattgttgtaagagactt	12	15	10	4	0	1	1	0	0	1	1	1	3	1	2	0	2	1	4	0	2	5	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:44449031G>C	uc010him.2	+	11	1593	c.1348G>C	c.(1348-1350)GTG>CTG	p.V450L	C3orf23_uc003cnd.3_Missense_Mutation_p.V450L|C3orf23_uc003cne.3_Missense_Mutation_p.V306L	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	450						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		TATACAAATGGTGGATTGTTG	0.358													19	28					0	0	0	0	C	44449031	C	C	44449031	3	2	16	1	0	0	0	0	1	0	0	0	2226	1261	44	4	1438	4	C3orf23	3	44449031	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1542784	44449031	153573399	96	3484											
ZNF660	285349	broad.mit.edu	37	chr3	44636619	44636619	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgagtgtgggaaagcctatCggtatagttcacagcttatt	10	13	12	6	1	1	1	1	1	0	0	2	2	1	2	1	2	2	3	1	2	5	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:44636619C>T	uc003cnl.1	+	3	1267	c.934C>T	c.(934-936)CGG>TGG	p.R312W		NM_173658	NP_775929	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	312	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		GAAAGCCTATCGGTATAGTTC	0.408													14	29					0	0	0	0	T	44636619	T	T	44636619	3	4	16	1	0	0	0	0	1	0	0	0	18137	875	31	1	936	1	ZNF660	3	44636619	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	187588	44636619	153385811	97	3485											
TGM4	7047	broad.mit.edu	37	chr3	44945437	44945437	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctgcccaagggctacgacGgctggcaggctgtggacgca	8	6	15	12	3	1	0	0	0	1	0	1	2	1	1	1	5	2	5	1	5	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:44945437G>A	uc003coc.3	+	9	1106	c.1033G>A	c.(1033-1035)GGC>AGC	p.G345S		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	345					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GGGCTACGACGGCTGGCAGGC	0.652													35	46					0	0	0	0	A	44945437	A	A	44945437	3	1	16	1	0	0	0	0	1	0	0	0	15898	1116	39	1	1067	1	TGM4	3	44945437	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	308818	44945437	153076993	98	3486											
USP19	10869	broad.mit.edu	37	chr3	49149744	49149744	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtagcccacacggtagcacCgggtacagcgcttcagcttt	9	8	11	13	3	1	0	1	0	0	0	1	0	1	0	2	2	5	6	2	2	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:49149744C>A	uc003cwd.1	-	18	2590	c.2429G>T	c.(2428-2430)CGG>CTG	p.R810L	USP19_uc003cwa.2_Missense_Mutation_p.R618L|USP19_uc003cvz.3_Missense_Mutation_p.R913L|USP19_uc011bcg.1_Missense_Mutation_p.R901L|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_Missense_Mutation_p.R568L|USP19_uc011bch.1_Missense_Mutation_p.R911L	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	810	Cytoplasmic (Potential).|MYND-type.				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACGGTAGCACCGGGTACAGCG	0.617													4	6					1.23904e-05	1.32813e-05	1	0	A	49149744	A	A	49149744	3	1	16	1	0	0	0	0	1	0	0	0	17118	652	23	3	1563	3	USP19	3	49149744	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4204307	49149744	148872686	99	3487											
FEZF2	55079	broad.mit.edu	37	chr3	62358002	62358002	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgctgaggagctcagacggcGggtacgcggtcgagtccagg	7	5	18	11	6	1	2	1	1	0	1	3	4	2	3	1	5	2	3	1	5	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:62358002G>C	uc003dlh.2	-	1	749	c.542C>G	c.(541-543)CCG>CGG	p.P181R	FEZF2_uc003dli.2_Missense_Mutation_p.P181R	NM_018008	NP_060478	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	181					transcription, DNA-dependent	nucleus	zinc ion binding			lung(1)	1		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		CTCAGACGGCGGGTACGCGGT	0.672													5	2					0	0	0	0	C	62358002	C	C	62358002	3	2	16	1	0	0	0	0	1	0	0	0	5858	1116	39	3	853	3	FEZF2	3	62358002	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	13208258	62358002	135664428	100	3488											
ROBO2	6092	broad.mit.edu	37	chr3	77651571	77651571	+	Frame_Shift_Del	DEL	G	-	-																															gcctgatccacaatggaaaaGctcaattcagcaaaaaacag																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:77651571delG	uc003dpy.3	+	20	3708	c.3065delG	c.(3064-3066)AGCfs	p.S1022fs	ROBO2_uc003dpz.2_Frame_Shift_Del_p.S1026fs|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Frame_Shift_Del_p.S1026fs|ROBO2_uc003dqa.2_Frame_Shift_Del_p.S149fs	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1022	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAATGGAAAAGCTCAATTCAG	0.443													---	---	---								-	77651571	-	-	77651571	7	5	16	1	0	1	0	1	0	0	0	0	13579	971	34	0	3145	0	ROBO2	3	77651571	Frame_Shift_Del	DEL	G	TCGA-BA-6869-01A-11D-1870-08	15293569	77651571	120370859	101	3489											
DPPA4	55211	broad.mit.edu	37	chr3	109047837	109047837	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actcactctcccttcttgctTttctggaacccaggcttgac	6	14	6	15	0	4	1	1	1	3	0	5	2	4	2	2	2	2	2	2	2	1	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:109047837T>A	uc003dxq.3	-	6	833	c.778A>T	c.(778-780)AAG>TAG	p.K260*	DPPA4_uc011bho.1_Missense_Mutation_p.K161I	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	260						nucleus	protein binding			upper_aerodigestive_tract(1)	1						CCTTCTTGCTTTTCTGGAACC	0.517													22	19					0	0	0	0	A	109047837	A	A	109047837	4	1	16	1	0	0	0	0	0	1	0	0	4758	1850	64	5	144	5	DPPA4	3	109047837	Nonsense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	31396266	109047837	88974593	102	3490											
SEMA5B	54437	broad.mit.edu	37	chr3	122662294	122662294	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgttacctggctcccacGatgagctggttcccggaggg	5	10	13	13	2	0	1	0	1	0	0	2	3	2	2	4	4	2	4	4	4	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:122662294G>T	uc003efz.1	-	4	721	c.417C>A	c.(415-417)ATC>ATA	p.I139I	SEMA5B_uc011bju.1_Silent_p.I81I|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.I139I|SEMA5B_uc010hro.1_Silent_p.I81I|SEMA5B_uc010hrp.1_Intron	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	139	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGGCTCCCACGATGAGCTGGT	0.602													9	16					1.76689e-08	2.02971e-08	1	0	T	122662294	T	T	122662294	2	4	16	1	0	0	0	0	0	0	0	1	14103	1048	37	3		3	SEMA5B	3	122662294	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	13614457	122662294	75360136	103	3491											
MYLK	4638	broad.mit.edu	37	chr3	123333078	123333078	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacttggcatcgtcatccccGcaaacatcactaataattaa	14	11	4	12	2	2	0	2	0	0	0	4	0	3	0	2	1	2	2	2	1	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:123333078G>A	uc003ego.2	-	34	5901	c.5619C>T	c.(5617-5619)TGC>TGT	p.C1873C	uc003egk.2_Intron|MYLK_uc003egl.2_Silent_p.C113C|MYLK_uc003egm.2_Silent_p.C112C|MYLK_uc010hrr.2_Silent_p.C308C|MYLK_uc011bjv.1_Silent_p.C673C|MYLK_uc011bjw.1_Silent_p.C1872C|MYLK_uc003egp.2_Silent_p.C1804C|MYLK_uc003egq.2_Silent_p.C1822C|MYLK_uc003egr.2_Silent_p.C1753C|MYLK_uc003egs.2_Silent_p.C1697C	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1873	Ig-like C2-type 9.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CGTCATCCCCGCAAACATCAC	0.498													4	156					0	0	0	0	A	123333078	A	A	123333078	2	1	16	1	0	0	0	0	0	0	0	1	10109	1079	38	1		1	MYLK	3	123333078	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	670784	123333078	74689352	104	3492											
ZNF148	7707	broad.mit.edu	37	chr3	125032301	125032301	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcactttcttgtaacacttCatctgcagcaaggatctcct	9	15	5	12	0	5	0	2	0	3	0	6	1	5	1	1	1	3	3	1	1	2	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:125032301C>T	uc003ehx.3	-	4	670	c.184G>A	c.(184-186)GAA>AAA	p.E62K	ZNF148_uc003ehz.3_Missense_Mutation_p.E62K|ZNF148_uc010hsa.2_Missense_Mutation_p.E62K|ZNF148_uc003eia.3_Missense_Mutation_p.E62K|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	62					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						TGTAACACTTCATCTGCAGCA	0.443													96	52					0	0	0	0	T	125032301	T	T	125032301	3	4	16	1	0	0	0	0	1	0	0	0	17801	835	29	2	2224	2	ZNF148	3	125032301	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1699223	125032301	72990129	105	3493											
RHO	6010	broad.mit.edu	37	chr3	129249874	129249874	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcgccgcacccccactcGccggctggtccaggtaatgg	5	6	12	18	4	0	0	0	0	0	0	2	0	1	0	6	4	1	3	6	4	1	1	rs139731264		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:129249874G>C	uc003emt.2	+	2	612	c.517G>C	c.(517-519)GCC>CCC	p.A173P		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	173	Helical; Name=4; (Potential).				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	ACCCCCACTCGCCGGCTGGTC	0.612													15	36					0	0	0	0	C	129249874	C	C	129249874	3	2	16	1	0	0	0	0	1	0	0	0	13395	1087	38	3	523	3	RHO	3	129249874	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4217573	129249874	68772556	106	3494											
COL6A6	131873	broad.mit.edu	37	chr3	130293227	130293227	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtatcgacatctactccgtGggcattggggatgtggatga	8	11	15	7	2	1	1	0	1	1	0	3	4	2	3	1	5	1	2	1	5	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:130293227G>A	uc010htl.2	+	7	3436	c.3405G>A	c.(3403-3405)GTG>GTA	p.V1135V		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1135	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TCTACTCCGTGGGCATTGGGG	0.552													45	28					0	0	0	0	A	130293227	A	A	130293227	2	1	16	1	0	0	0	0	0	0	0	1	3718	1335	47	4		4	COL6A6	3	130293227	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1043353	130293227	67729203	107	3495											
SLCO2A1	6578	broad.mit.edu	37	chr3	133657272	133657272	+	Splice_Site	DEL	C	-	-																															agaggggtcttagacacttaCccagcaagcgcatcaacaag																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:133657272delC	uc003eqa.3	-	12	1964	c.1690_splice	c.e12+1	p.A564_splice	SLCO2A1_uc003eqb.3_Splice_Site_p.A488_splice	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,						sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						TAGACACTTACCCAGCAAGCG	0.537													---	---	---								-	133657272	-	-	133657272	8	5	16	1	0	1	0	1	0	0	1	0	14790	521	18	0	252	0	SLCO2A1	3	133657272	Splice_Site	DEL	C	TCGA-BA-6869-01A-11D-1870-08	3364045	133657272	64365158	108	3496											
CLSTN2	64084	broad.mit.edu	37	chr3	140167468	140167468	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttccctccagatcgtcAcagagctgcagactaattac	10	11	7	13	1	2	3	1	0	1	3	5	3	4	3	2	0	3	2	2	0	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:140167468A>T	uc003etn.2	+	6	1085	c.895A>T	c.(895-897)ACA>TCA	p.T299S	CLSTN2_uc003etm.2_Missense_Mutation_p.T299S	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	299	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CCAGATCGTCACAGAGCTGCA	0.532										HNSCC(16;0.037)			35	127					0	0	0	0	T	140167468	T	T	140167468	3	4	16	1	0	0	0	0	1	0	0	0	3577	159	6	5	917	5	CLSTN2	3	140167468	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	6510196	140167468	57854962	109	3497											
MME	4311	broad.mit.edu	37	chr3	154802866	154802866	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatggtatttgcaagtcatCagactgcataaaatcaggta	15	11	9	6	0	3	2	3	0	0	2	3	2	3	2	0	2	2	4	0	2	5	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:154802866C>G	uc010hvr.1	+	3	390	c.179C>G	c.(178-180)TCA>TGA	p.S60*	MME_uc003fab.1_Nonsense_Mutation_p.S60*|MME_uc003fac.1_Nonsense_Mutation_p.S60*|MME_uc003fad.1_Nonsense_Mutation_p.S60*|MME_uc003fae.1_Nonsense_Mutation_p.S60*	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	60	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	tgcaagtcatcagactgcata	0.179													42	12					0	0	0	0	G	154802866	G	G	154802866	4	3	16	1	0	0	0	0	0	1	0	0	9698	838	29	2	185	2	MME	3	154802866	Nonsense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	14635398	154802866	43219564	110	3498											
VEPH1	79674	broad.mit.edu	37	chr3	157146169	157146169	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagtagatggtactgttctGgctgttccagctgagacatc	8	13	12	8	0	1	2	0	1	1	2	3	3	2	2	1	2	2	7	1	2	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:157146169G>T	uc003fbj.1	-	5	955	c.638C>A	c.(637-639)CCA>CAA	p.P213Q	VEPH1_uc003fbk.1_Missense_Mutation_p.P213Q|VEPH1_uc010hvu.1_Missense_Mutation_p.P213Q	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	213						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			GTACTGTTCTGGCTGTTCCAG	0.443													102	28					5.84261e-33	8.79134e-33	1	0	T	157146169	T	T	157146169	3	4	16	1	0	0	0	0	1	0	0	0	17222	1348	47	4	1903	4	VEPH1	3	157146169	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2343303	157146169	40876261	111	3499											
SI	6476	broad.mit.edu	37	chr3	164724621	164724621	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactcatgagtaggtttcatCtgtgaccatccatagagatt	11	14	8	8	0	3	3	2	2	1	1	4	4	4	3	2	1	1	2	2	1	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:164724621C>A	uc003fei.2	-	37	4451	c.4389G>T	c.(4387-4389)CAG>CAT	p.Q1463H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1463	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAGGTTTCATCTGTGACCATC	0.358										HNSCC(35;0.089)			40	14					3.77016e-25	5.50495e-25	1	0	A	164724621	A	A	164724621	3	1	16	1	0	0	0	0	1	0	0	0	14362	912	32	2	1142	2	SI	3	164724621	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	7578452	164724621	33297809	112	3500											
SI	6476	broad.mit.edu	37	chr3	164785240	164785240	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtaaactcttttacatactGatgaggaacttcatatcttc	13	15	5	8	0	3	2	1	2	2	0	4	3	3	3	0	1	4	1	0	1	6	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:164785240G>C	uc003fei.2	-	6	585	c.523C>G	c.(523-525)CAG>GAG	p.Q175E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	175	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTTACATACTGATGAGGAACT	0.338										HNSCC(35;0.089)			26	147					0	0	0	0	C	164785240	C	C	164785240	3	2	16	1	0	0	0	0	1	0	0	0	14362	1299	45	2	5132	2	SI	3	164785240	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	60619	164785240	33237190	113	3501											
SLITRK3	22865	broad.mit.edu	37	chr3	164907946	164907946	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttccagctggagctccaTcaggcttctgccaatgtgat	7	13	9	12	0	3	1	1	1	2	0	5	2	5	2	3	2	3	3	3	2	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:164907946T>A	uc003fej.3	-	2	1117	c.673A>T	c.(673-675)ATG>TTG	p.M225L	SLITRK3_uc003fek.2_Missense_Mutation_p.M225L	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	225	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TGGAGCTCCATCAGGCTTCTG	0.438										HNSCC(40;0.11)			60	80					0	0	0	0	A	164907946	A	A	164907946	3	1	16	1	0	0	0	0	1	0	0	0	14808	1435	50	5	2264	5	SLITRK3	3	164907946	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	122706	164907946	33114484	114	3502											
ZBBX	79740	broad.mit.edu	37	chr3	167068208	167068208	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcattttagaaagccatacCtgcaaaagagttgttctgtg	13	13	8	7	0	2	2	1	0	1	2	2	2	2	2	2	0	3	3	2	0	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:167068208C>A	uc003fep.2	-	9	851	c.528G>T	c.(526-528)CAG>CAT	p.Q176H	ZBBX_uc011bpc.1_Missense_Mutation_p.Q176H|ZBBX_uc003feq.2_Missense_Mutation_p.Q147H	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	176						intracellular	zinc ion binding			ovary(2)	2						AAAGCCATACCTGCAAAAGAG	0.343													53	242					8.13277e-46	1.24715e-45	1	0	A	167068208	A	A	167068208	3	1	16	1	0	0	0	0	1	0	0	0	17584	695	24	4	1926	4	ZBBX	3	167068208	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2160262	167068208	30954222	115	3503											
MECOM	2122	broad.mit.edu	37	chr3	168834254	168834254	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatgcctattggcgccaaaaTagtcagcaaggcccgggttg	10	8	13	10	2	1	0	1	0	0	0	1	1	1	0	3	3	2	2	3	3	5	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:168834254T>C	uc003ffi.3	-	7	1111	c.842A>G	c.(841-843)TAT>TGT	p.Y281C	MECOM_uc010hwk.1_Missense_Mutation_p.Y304C|MECOM_uc003ffj.3_Missense_Mutation_p.Y346C|MECOM_uc011bpi.1_Missense_Mutation_p.Y282C|MECOM_uc003ffn.3_Missense_Mutation_p.Y281C|MECOM_uc003ffk.2_Missense_Mutation_p.Y281C|MECOM_uc003ffl.2_Missense_Mutation_p.Y441C|MECOM_uc011bpj.1_Missense_Mutation_p.Y469C|MECOM_uc011bpk.1_Missense_Mutation_p.Y271C|MECOM_uc010hwn.2_Missense_Mutation_p.Y469C	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	281					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GGCGCCAAAATAGTCAGCAAG	0.493													15	79					0	0	0	0	C	168834254	C	C	168834254	3	2	16	1	0	0	0	0	1	0	0	0	9475	1406	49	5	2353	5	MECOM	3	168834254	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	1766046	168834254	29188176	116	3504											
TNIK	23043	broad.mit.edu	37	chr3	170843830	170843830	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctccacgcggtgggaggtCacgttcagagcctcctgaaa	9	8	12	12	3	3	2	2	1	1	1	5	3	4	3	3	3	1	1	3	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:170843830C>A	uc003fhh.2	-	17	2229	c.1884G>T	c.(1882-1884)GTG>GTT	p.V628V	TNIK_uc003fhi.2_Silent_p.V573V|TNIK_uc003fhj.2_Silent_p.V599V|TNIK_uc003fhk.2_Silent_p.V628V|TNIK_uc003fhl.2_Silent_p.V544V|TNIK_uc003fhm.2_Silent_p.V573V|TNIK_uc003fhn.2_Silent_p.V599V|TNIK_uc003fho.2_Silent_p.V544V	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	628	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGTGGGAGGTCACGTTCAGAG	0.577													18	83					0.00121646	0.00126173	1	0	A	170843830	A	A	170843830	2	1	16	1	0	0	0	0	0	0	0	1	16379	813	29	2		2	TNIK	3	170843830	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2009576	170843830	27178600	117	3505											
CCDC39	339829	broad.mit.edu	37	chr3	180372672	180372672	+	Frame_Shift_Del	DEL	C	-	-																															gttattcccaatctcactttCcaaaaacttgatcttttctt																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:180372672delC	uc010hxe.2	-	7	923	c.808delG	c.(808-810)GAAfs	p.E270fs	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	270	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ATCTCACTTTCCAAAAACTTG	0.318													---	---	---								-	180372672	-	-	180372672	7	5	16	1	0	1	0	1	0	0	0	0	2824	864	30	0	2073	0	CCDC39	3	180372672	Frame_Shift_Del	DEL	C	TCGA-BA-6869-01A-11D-1870-08	9528842	180372672	17649758	118	3506											
MAP3K13	9175	broad.mit.edu	37	chr3	185161246	185161246	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggaaggggtgtttgtactCaggccccatgttattgtatt	7	16	12	6	0	1	0	1	0	0	0	1	1	1	1	2	4	1	4	2	4	4	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr3:185161246C>T	uc010hyf.2	+	5	939	c.673C>T	c.(673-675)CAG>TAG	p.Q225*	MAP3K13_uc011brt.1_Nonsense_Mutation_p.Q18*|MAP3K13_uc003fph.3_5'UTR|MAP3K13_uc011bru.1_Nonsense_Mutation_p.Q81*|MAP3K13_uc003fpi.2_Nonsense_Mutation_p.Q225*|MAP3K13_uc010hyg.2_Intron	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	225	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TGTTTGTACTCAGGCCCCATG	0.308													76	35					0	0	0	0	T	185161246	T	T	185161246	4	4	16	1	0	0	0	0	0	1	0	0	9300	827	29	2	683	2	MAP3K13	3	185161246	Nonsense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4788574	185161246	12861184	119	3507											
DOK7	285489	broad.mit.edu	37	chr4	3494900	3494900	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccgggacagtcgagtaccAggtgcccacctccctgcggg	6	5	14	16	3	0	0	0	0	0	0	2	2	1	1	5	3	3	1	5	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:3494900A>T	uc003ghd.2	+	7	1257	c.1187A>T	c.(1186-1188)CAG>CTG	p.Q396L	DOK7_uc003ghe.2_Missense_Mutation_p.Q258L|DOK7_uc003ghf.2_Missense_Mutation_p.R138W|DOK7_uc003ghg.1_Missense_Mutation_p.Q86L	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	396					positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GTCGAGTACCAGGTGCCCACC	0.692													6	10					0	0	0	0	T	3494900	T	T	3494900	3	4	16	1	0	0	0	0	1	0	0	0	4724	188	7	5	1213	5	DOK7	4	3494900	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08		3494900	187659376	120	3508											
LRPAP1	4043	broad.mit.edu	37	chr4	3516631	3516631	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggttgtgcttctcgatttTggcttcgaagtgcttgagct	4	17	13	7	2	1	1	0	1	1	0	3	3	1	1	0	2	3	5	0	2	1	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:3516631T>A	uc003ghi.2	-	7	944	c.859A>T	c.(859-861)AAA>TAA	p.K287*		NM_002337	NP_002328	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein	287	LDL receptor binding (Potential).|Potential.				negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		TTCTCGATTTTGGCTTCGAAG	0.592													43	92					0	0	0	0	A	3516631	A	A	3516631	4	1	16	1	0	0	0	0	0	1	0	0	9014	1821	63	5	222	5	LRPAP1	4	3516631	Nonsense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	21731	3516631	187637645	121	3509											
ZNF518B	85460	broad.mit.edu	37	chr4	10444812	10444812	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgactcatccactcttcctgGtcttcatacagtcgcccaca	8	12	5	16	1	4	1	2	1	2	0	7	1	6	1	3	1	1	0	3	1	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:10444812G>A	uc003gmn.2	-	3	3628	c.3141C>T	c.(3139-3141)GAC>GAT	p.D1047D		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	1047	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						ACTCTTCCTGGTCTTCATACA	0.413													31	80					0	0	0	0	A	10444812	A	A	10444812	2	1	16	1	0	0	0	0	0	0	0	1	18030	1252	44	4		4	ZNF518B	4	10444812	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	6928181	10444812	180709464	122	3510											
KCNIP4	80333	broad.mit.edu	37	chr4	21305453	21305454	+	Missense_Mutation	DNP	CC	AG	AG																															ctaaacctgcttcaatcagcCcaaactgttccaataattta																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:21305453_21305454CC>AG	uc003gqf.1	-	1	76_77	c.76_77GG>CT	c.(76-78)GGG>CTG	p.G26L	KCNIP4_uc003gqg.1_Intron|KCNIP4_uc003gqh.1_Intron|KCNIP4_uc003gqi.1_Intron	NM_147183	NP_671712	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4 isoform 4	Error:Variant_position_missing_in_Q6PIL6_after_alignment						plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)				TTCAATCAGCCCAAACTGTTCC	0.396													8	37					0	0	0	0	AG	21305454	AG	AG	21305453	3	1	16	1	0	0	0	0	1	0	0	0	8081	623	22	4	752	4	KCNIP4	4	21305453	Missense_Mutation	DNP	CC	TCGA-BA-6869-01A-11D-1870-08	10860641	21305453	169848823	123	3511											
ARAP2	116984	broad.mit.edu	37	chr4	36075423	36075423	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttttcgttcctttccagctGgtggccatatatcatattca	7	17	7	10	1	2	0	2	0	0	0	5	0	4	0	3	2	1	3	3	2	3	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:36075423G>C	uc003gsq.1	-	32	4969	c.4631C>G	c.(4630-4632)CCA>CGA	p.P1544R	ARAP2_uc003gso.2_RNA	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1544					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTTTCCAGCTGGTGGCCATAT	0.413													36	67					0	0	0	0	C	36075423	C	C	36075423	3	2	16	1	0	0	0	0	1	0	0	0	839	1348	47	4	491	4	ARAP2	4	36075423	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	14769970	36075423	155078853	124	3512											
PHOX2B	8929	broad.mit.edu	37	chr4	41749478	41749478	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctctttgagctgggcactgGtgaaagtggtgcggatgcgc	6	10	17	8	2	1	2	0	2	1	0	1	3	1	3	0	4	3	3	0	4	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:41749478G>C	uc003gwf.3	-	2	677	c.317C>G	c.(316-318)ACC>AGC	p.T106S		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	106	Homeobox.				positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						CTGGGCACTGGTGAAAGTGGT	0.572			Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				23	59					0	0	0	0	C	41749478	C	C	41749478	3	2	16	1	0	0	0	0	1	0	0	0	11914	1261	44	4	635	4	PHOX2B	4	41749478	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	5674055	41749478	149404798	125	3513											
PDGFRA	5156	broad.mit.edu	37	chr4	55156559	55156559	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgtgtggactcagacaatgCatacattggtgtcacctaca	11	10	10	10	1	2	1	2	0	0	1	2	2	2	2	1	2	3	1	1	2	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:55156559C>A	uc003han.3	+	22	3291	c.2960C>A	c.(2959-2961)GCA>GAA	p.A987E	PDGFRA_uc003haa.2_Missense_Mutation_p.A747E	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	987	Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TCAGACAATGCATACATTGGT	0.468			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			28	82					2.12542e-12	2.68716e-12	1	0	A	55156559	A	A	55156559	3	1	16	1	0	0	0	0	1	0	0	0	11715	710	25	4	3042	4	PDGFRA	4	55156559	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	13407081	55156559	135997717	126	3514											
KIT	3815	broad.mit.edu	37	chr4	55592133	55592133	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctagtgcattcaagcacaAtggcacggttgaatgtaagg	12	11	11	7	1	2	1	1	1	1	0	2	1	2	1	0	3	2	5	0	3	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:55592133A>T	uc010igr.2	+	9	1544	c.1457A>T	c.(1456-1458)AAT>ATT	p.N486I	KIT_uc010igs.2_Missense_Mutation_p.N486I|KIT_uc011bzw.1_5'Flank|KIT_uc010igt.1_5'Flank	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	486	Extracellular (Potential).|Ig-like C2-type 5.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.N486D(1)|p.D479fs*2(1)		soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TTCAAGCACAATGGCACGGTT	0.403		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				24	50					0	0	0	0	T	55592133	T	T	55592133	3	4	16	1	0	0	0	0	1	0	0	0	8368	101	4	5	1491	5	KIT	4	55592133	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	435574	55592133	135562143	127	3515											
KDR	3791	broad.mit.edu	37	chr4	55987310	55987310	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccttaattgtaagtatgtCtttttgtatgctgagcctgg	8	17	10	6	0	1	1	0	1	1	0	1	1	1	1	2	1	3	4	2	1	4	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:55987310C>T	uc003has.2	-	2	417	c.115G>A	c.(115-117)GAC>AAC	p.D39N	KDR_uc003hat.1_Missense_Mutation_p.D39N|KDR_uc011bzx.1_Missense_Mutation_p.D39N	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	39	Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GTAAGTATGTCTTTTTGTATG	0.333			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			16	62					0	0	0	0	T	55987310	T	T	55987310	3	4	16	1	0	0	0	0	1	0	0	0	8178	913	32	2	4071	2	KDR	4	55987310	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	395177	55987310	135166966	128	3516											
KIAA1211	57482	broad.mit.edu	37	chr4	57190344	57190344	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaagtccactgctctgccAgaagagaagaggcccgagac	13	4	11	13	1	1	4	0	0	1	4	2	6	2	4	3	1	2	1	3	1	3	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:57190344A>G	uc003hbk.2	+	10	3844	c.3453A>G	c.(3451-3453)CCA>CCG	p.P1151P	KIAA1211_uc010iha.2_Silent_p.P1144P	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	1151										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CTGCTCTGCCAGAAGAGAAGA	0.572													16	37					0	0	0	0	G	57190344	G	G	57190344	2	3	16	1	0	0	0	0	0	0	0	1	8254	175	7	5		5	KIAA1211	4	57190344	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	1203034	57190344	133963932	129	3517											
TECRL	253017	broad.mit.edu	37	chr4	65180375	65180375	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtatcacttactgtaccactGggtggcgtaatcttctagca	9	13	9	10	1	3	0	1	0	2	0	3	0	3	0	1	2	3	4	1	2	5	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:65180375G>A	uc003hcv.2	-	5	651	c.542C>T	c.(541-543)CCA>CTA	p.P181L	TECRL_uc003hcw.2_Missense_Mutation_p.P181L	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	181					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						CTGTACCACTGGGTGGCGTAA	0.303													19	42					0	0	0	0	A	65180375	A	A	65180375	3	1	16	1	0	0	0	0	1	0	0	0	15812	1348	47	4	581	4	TECRL	4	65180375	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	7990031	65180375	125973901	130	3518											
TMPRSS11F	389208	broad.mit.edu	37	chr4	68919654	68919654	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccagtctttgaggcaatccaAtctcgatacttagttactct	10	14	6	11	1	3	1	0	1	3	0	5	2	4	1	2	1	2	2	2	1	5	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:68919654A>G	uc003hdt.1	-	10	1339	c.1290T>C	c.(1288-1290)GAT>GAC	p.D430D	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	430	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AGGCAATCCAATCTCGATACT	0.408													33	60					0	0	0	0	G	68919654	G	G	68919654	2	3	16	1	0	0	0	0	0	0	0	1	16309	98	4	5		5	TMPRSS11F	4	68919654	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	3739279	68919654	122234622	131	3519											
UGT2B10	7365	broad.mit.edu	37	chr4	69693223	69693223	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acttcaacacaatgtcgagtAcagacctgctgaatgcactg	13	9	8	11	1	1	2	1	1	0	1	2	3	1	2	1	0	4	3	1	0	4	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:69693223A>G	uc003hee.2	+	5	1289	c.1264A>G	c.(1264-1266)ACA>GCA	p.T422A	UGT2B10_uc011cam.1_Missense_Mutation_p.T338A	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	422					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						AATGTCGAGTACAGACCTGCT	0.388													53	91					0	0	0	0	G	69693223	G	G	69693223	3	3	16	1	0	0	0	0	1	0	0	0	17024	391	14	5	1282	5	UGT2B10	4	69693223	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	773569	69693223	121461053	132	3520											
UGT2B7	7364	broad.mit.edu	37	chr4	69978304	69978304	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaacaccttcgggttgcagcCcacgacctcacctggttcca	9	8	8	16	2	1	0	1	0	0	0	3	1	2	0	5	2	3	3	5	2	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:69978304C>A	uc003heg.3	+	6	1486	c.1440C>A	c.(1438-1440)GCC>GCA	p.A480A	UGT2B7_uc010ihq.2_3'UTR	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	480					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GGGTTGCAGCCCACGACCTCA	0.483													52	118					4.25531e-23	6.06146e-23	1	0	A	69978304	A	A	69978304	2	1	16	1	0	0	0	0	0	0	0	1	17030	610	22	4		4	UGT2B7	4	69978304	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	285081	69978304	121175972	133	3521											
GC	2638	broad.mit.edu	37	chr4	72622457	72622457	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactttggtgtttcctggatCacacacatctttgtttgtgg	6	17	10	8	0	2	0	1	0	1	0	3	2	3	1	1	3	0	2	1	3	0	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:72622457C>A	uc003hge.2	-	8	1159	c.1006G>T	c.(1006-1008)GAT>TAT	p.D336Y	GC_uc003hgd.2_Missense_Mutation_p.D214Y|GC_uc010iie.2_Missense_Mutation_p.D336Y|GC_uc010iif.2_Missense_Mutation_p.D355Y	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	336	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TTTCCTGGATCACACACATCT	0.453													8	33					5.18039e-06	5.65695e-06	1	0	A	72622457	A	A	72622457	3	1	16	1	0	0	0	0	1	0	0	0	6317	826	29	2	438	2	GC	4	72622457	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2644153	72622457	118531819	134	3522											
GC	2638	broad.mit.edu	37	chr4	72629169	72629169	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taagcagcatattgtgagcaGactctatttgacagagtggt	12	12	11	6	0	1	4	0	2	1	2	1	4	1	4	0	1	3	3	0	1	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:72629169G>C	uc003hge.2	-	6	810	c.657C>G	c.(655-657)GTC>GTG	p.V219V	GC_uc003hgd.2_Silent_p.V97V|GC_uc010iie.2_Silent_p.V219V|GC_uc010iif.2_Silent_p.V238V	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	219	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	ATTGTGAGCAGACTCTATTTG	0.368													16	39					0	0	0	0	C	72629169	C	C	72629169	2	2	16	1	0	0	0	0	0	0	0	1	6317	929	33	2		2	GC	4	72629169	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	6712	72629169	118525107	135	3523											
NAA11	84779	broad.mit.edu	37	chr4	80247017	80247017	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcaggtcgtctggctgagcGttgcggatgttcataatggc	7	12	14	8	3	3	1	2	1	1	0	4	2	3	2	0	4	2	3	0	4	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:80247017G>C	uc003hlt.3	-	1	155	c.15C>G	c.(13-15)AAC>AAG	p.N5K		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	5	Interaction with NAA15 (By similarity).|N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						CTGGCTGAGCGTTGCGGATGT	0.512													13	24					0	0	0	0	C	80247017	C	C	80247017	3	2	16	1	0	0	0	0	1	0	0	0	10170	1136	40	3	678	3	NAA11	4	80247017	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	7617848	80247017	110907259	136	3524											
AGXT2L1	64850	broad.mit.edu	37	chr4	109674060	109674060	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaatacaaaccttccttccActgttatgagcatcttcaat	13	14	3	11	0	2	1	1	1	1	0	4	1	4	1	3	0	3	2	3	0	6	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:109674060A>T	uc003hzc.2	-	6	790	c.609T>A	c.(607-609)AGT>AGA	p.S203R	AGXT2L1_uc010imc.2_Missense_Mutation_p.S197R|AGXT2L1_uc011cfm.1_Missense_Mutation_p.S163R|AGXT2L1_uc011cfn.1_Missense_Mutation_p.S130R|AGXT2L1_uc011cfo.1_Missense_Mutation_p.S145R	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	203					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		CCTTCCTTCCACTGTTATGAG	0.363													33	86					0	0	0	0	T	109674060	T	T	109674060	3	4	16	1	0	0	0	0	1	0	0	0	406	156	6	5	922	5	AGXT2L1	4	109674060	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	29427043	109674060	81480216	137	3525											
ENPEP	2028	broad.mit.edu	37	chr4	111452358	111452358	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttaaaaaaattttagttatAcatggaatatcccagttaaa	18	15	4	4	0	0	0	0	0	0	0	1	1	1	1	1	1	1	2	1	1	11	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:111452358A>G	uc003iab.3	+	11	2074	c.1732A>G	c.(1732-1734)ACA>GCA	p.T578A		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	578	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ttttaGTTATACATGGAATAT	0.184													15	22					0	0	0	0	G	111452358	G	G	111452358	3	3	16	1	0	0	0	0	1	0	0	0	5152	391	14	5	1774	5	ENPEP	4	111452358	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	1778298	111452358	79701918	138	3526											
ANK2	287	broad.mit.edu	37	chr4	114214656	114214656	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatctccgtggtcgacaccCtgaaggttgtgactgaggag	9	9	13	10	2	1	3	0	3	1	0	3	5	1	4	2	3	0	1	2	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:114214656C>A	uc003ibe.3	+	22	2537	c.2437C>A	c.(2437-2439)CTG>ATG	p.L813M	ANK2_uc003ibd.3_Missense_Mutation_p.L792M|ANK2_uc003ibf.3_Missense_Mutation_p.L813M|ANK2_uc011cgc.1_Missense_Mutation_p.L22M|ANK2_uc003ibc.2_Missense_Mutation_p.L789M|ANK2_uc011cgb.1_Missense_Mutation_p.L828M	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	813	ANK 24.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GGTCGACACCCTGAAGGTTGT	0.408													17	26					5.3912e-06	5.85722e-06	1	0	A	114214656	A	A	114214656	3	1	16	1	0	0	0	0	1	0	0	0	621	680	24	4	2548	4	ANK2	4	114214656	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2762298	114214656	76939620	139	3527											
PHF17	79960	broad.mit.edu	37	chr4	129770159	129770159	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtctgaagagaaatccctCatgttcatcaggcccaagaa	13	9	9	10	0	4	3	3	1	1	2	5	4	5	3	2	1	0	1	2	1	4	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:129770159C>T	uc003igk.2	+	5	601	c.321C>T	c.(319-321)CTC>CTT	p.L107L	PHF17_uc003igj.2_Silent_p.L107L|PHF17_uc003igl.2_Intron|PHF17_uc011cgy.1_Silent_p.L107L|PHF17_uc003igm.2_Silent_p.L107L	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	107					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						AGAAATCCCTCATGTTCATCA	0.517													28	64					0	0	0	0	T	129770159	T	T	129770159	2	4	16	1	0	0	0	0	0	0	0	1	11883	813	29	2		2	PHF17	4	129770159	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	15555503	129770159	61384117	140	3528											
PCDH18	54510	broad.mit.edu	37	chr4	138452706	138452706	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcgatattaaaaaaatcAttggcagagagcgagtatgt	16	10	9	6	2	1	1	1	0	0	1	2	4	1	1	1	1	1	2	1	1	6	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:138452706A>T	uc003ihe.3	-	1	924	c.537T>A	c.(535-537)AAT>AAA	p.N179K	PCDH18_uc003ihf.3_Missense_Mutation_p.N172K|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_5'UTR|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	179	Extracellular (Potential).|Cadherin 2.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TAAAAAAATCATTGGCAGAGA	0.483													17	40					0	0	0	0	T	138452706	T	T	138452706	3	4	16	1	0	0	0	0	1	0	0	0	11567	214	8	5	2886	5	PCDH18	4	138452706	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	8682547	138452706	52701570	141	3529											
RNF150	57484	broad.mit.edu	37	chr4	142053645	142053645	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgggtcggggcggcgaacttGgtgttggggtcgcaggccag	4	7	21	9	5	0	0	0	0	0	0	2	1	0	0	1	8	1	2	1	8	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:142053645G>T	uc003iio.1	-	1	972	c.318C>A	c.(316-318)ACC>ACA	p.T106T	RNF150_uc010iok.1_Silent_p.T106T|RNF150_uc003iip.1_Silent_p.T106T	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	106	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					CGGCGAACTTGGTGTTGGGGT	0.672													8	10					5.18039e-06	5.65695e-06	1	0	T	142053645	T	T	142053645	2	4	16	1	0	0	0	0	0	0	0	1	13516	1335	47	4		4	RNF150	4	142053645	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3600939	142053645	49100631	142	3530											
GUCY1A3	2982	broad.mit.edu	37	chr4	156629432	156629432	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaaaaacaattgcagagcAagcagttgcagcaggtaata	18	7	10	6	0	0	2	0	1	0	1	0	2	0	2	0	1	6	7	0	1	7	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:156629432A>C	uc003iov.2	+	6	898	c.362A>C	c.(361-363)CAA>CCA	p.Q121P	GUCY1A3_uc003iou.2_Missense_Mutation_p.Q121P|GUCY1A3_uc010iqc.2_Missense_Mutation_p.Q121P|GUCY1A3_uc003iow.2_Missense_Mutation_p.Q121P|GUCY1A3_uc010iqd.2_Missense_Mutation_p.Q121P|GUCY1A3_uc003iox.2_Missense_Mutation_p.Q121P|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.Q121P|GUCY1A3_uc010iqe.2_5'UTR|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.Q121P	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	121					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ATTGCAGAGCAAGCAGTTGCA	0.274													29	56					0	0	0	0	C	156629432	C	C	156629432	3	2	16	1	0	0	0	0	1	0	0	0	6933	130	5	5	372	5	GUCY1A3	4	156629432	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	14575787	156629432	34524844	143	3531											
NPY1R	4886	broad.mit.edu	37	chr4	164247365	164247365	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cattgcacaaaaggattcaaCttacacatcgcctcaccaaa	16	8	4	13	1	2	0	2	0	0	0	3	1	2	1	2	1	3	1	2	1	5	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:164247365C>G	uc003iqm.1	-	2	608	c.342G>C	c.(340-342)AAG>AAC	p.K114N	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	114	Extracellular (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AAGGATTCAACTTACACATCG	0.443													19	46					0	0	0	0	G	164247365	G	G	164247365	3	3	16	1	0	0	0	0	1	0	0	0	10662	564	20	4	820	4	NPY1R	4	164247365	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	7617933	164247365	26906911	144	3532											
TRIM60	166655	broad.mit.edu	37	chr4	165962140	165962140	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tagatctcaacacagcacatCctcaacttcttgtctctgag	11	12	5	13	0	4	2	2	1	3	1	7	2	5	2	1	0	3	1	1	0	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:165962140C>A	uc003iqy.1	+	3	1086	c.916C>A	c.(916-918)CCT>ACT	p.P306T	TRIM60_uc010iqx.1_Missense_Mutation_p.P306T	NM_152620	NP_689833	Q495X7	TRI60_HUMAN	ring finger protein 129	306	B30.2/SPRY.					intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		CACAGCACATCCTCAACTTCT	0.383													36	77					9.45814e-24	1.35934e-23	1	0	A	165962140	A	A	165962140	3	1	16	1	0	0	0	0	1	0	0	0	16602	855	30	2	918	2	TRIM60	4	165962140	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1714775	165962140	25192136	145	3533											
DDX60L	91351	broad.mit.edu	37	chr4	169305796	169305796	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctctgggtcatctcccttGgaagccagcagcatgagtcg	7	10	11	13	1	3	1	1	1	2	0	6	2	4	2	3	2	3	2	3	2	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:169305796G>T	uc003irq.3	-	30	4304	c.4083C>A	c.(4081-4083)TCC>TCA	p.S1361S		NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1361							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CATCTCCCTTGGAAGCCAGCA	0.547													10	22					9.70103e-10	1.15155e-09	1	0	T	169305796	T	T	169305796	2	4	16	1	0	0	0	0	0	0	0	1	4396	1335	47	4		4	DDX60L	4	169305796	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3343656	169305796	21848480	146	3534											
PALLD	23022	broad.mit.edu	37	chr4	169630280	169630280	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcagcaaccagcactgccCagctggttgtcacctcaggt	9	8	10	14	0	3	0	3	0	0	0	3	1	3	0	3	2	5	4	3	2	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr4:169630280C>A	uc011cjx.1	+	9	1814	c.1603C>A	c.(1603-1605)CAG>AAG	p.Q535K	PALLD_uc003iru.2_Missense_Mutation_p.Q535K|PALLD_uc003irv.2_Missense_Mutation_p.Q153K	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	535	Ig-like C2-type 2.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CAGCACTGCCCAGCTGGTTGT	0.488									Pancreatic_Cancer_Familial_Clustering_of				23	45					9.57634e-11	1.16479e-10	1	0	A	169630280	A	A	169630280	3	1	16	1	0	0	0	0	1	0	0	0	11461	595	21	4	1633	4	PALLD	4	169630280	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	324484	169630280	21523996	147	3535											
IRX1	79192	broad.mit.edu	37	chr5	3599662	3599663	+	Nonsense_Mutation	DNP	GG	CT	CT																															ggagcgcgcagcaaggaccaGgaagatggagcgctcttcgg																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:3599662_3599663GG>CT	uc003jde.2	+	2	652_653	c.600_601GG>CT	c.(598-603)CAGGAA>CACTAA	p.200_201QE>H*		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	200_201						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GCAAGGACCAGGAAGATGGAGC	0.624													35	56					0	0	0	0	CT	3599663	CT	CT	3599662	4	2	16	1	0	0	0	0	0	1	0	0	7882	991	35	4	606	4	IRX1	5	3599662	Nonsense_Mutation	DNP	GG	TCGA-BA-6869-01A-11D-1870-08		3599662	177315598	148	3536											
SEMA5A	9037	broad.mit.edu	37	chr5	9154600	9154600	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccccggagatgccctacCtgcgtgtgcggtagaactgg	7	8	14	12	3	0	3	0	1	0	2	0	4	0	3	4	3	5	1	4	3	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:9154600C>A	uc003jek.2	-	12	2193	c.1481G>T	c.(1480-1482)AGC>ATC	p.S494I		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	494	Extracellular (Potential).			S -> R (in Ref. 2; AAC14668).	cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GATGCCCTACCTGCGTGTGCG	0.612													38	39					3.28013e-08	3.76129e-08	1	0	A	9154600	A	A	9154600	3	1	16	1	0	0	0	0	1	0	0	0	14102	695	24	4	1791	4	SEMA5A	5	9154600	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	5554938	9154600	171760660	149	3537											
CCT5	22948	broad.mit.edu	37	chr5	10250045	10250047	+	5'Flank	DEL	AAC	-	-																															aaaaaaaaaaaaaaaaaaaaAaccggaaatgggtcctacca																								rs140525101	by1000genomes	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:10250045_10250047delAAC	uc003jeq.2	+						FAM173B_uc003jeo.2_5'Flank|FAM173B_uc003jep.2_5'Flank|FAM173B_uc010itr.2_5'Flank|CCT5_uc011cmq.1_5'Flank|CCT5_uc003jer.2_5'Flank|CCT5_uc010its.2_5'Flank|CCT5_uc011cmr.1_5'Flank|CCT5_uc011cms.1_5'Flank|CCT5_uc011cmt.1_5'Flank	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)						'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						aaaaaaaaaaaaCCGGAAATGGG	0.424													---	---	---								-	10250047	-	-	10250045	6	5	16	0	1	1	0	1	0	0	0	0	2971	29	1	0		0	CCT5	5	10250045	5'Flank	DEL	AAC	TCGA-BA-6869-01A-11D-1870-08	1095445	10250045	170665215	150	3538											
ADAMTS12	81792	broad.mit.edu	37	chr5	33535075	33535075	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggacagtcctcttctgaaagCcacctccacaggaagtggaa	12	7	10	12	0	2	1	0	1	2	0	4	4	4	4	4	3	1	0	4	3	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:33535075C>A	uc003jia.1	-	23	4632	c.4469G>T	c.(4468-4470)GGC>GTC	p.G1490V	ADAMTS12_uc010iuq.1_Missense_Mutation_p.G1405V	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1490	TSP type-1 8.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CTTCTGAAAGCCACCTCCACA	0.493										HNSCC(64;0.19)			32	44					1.56442e-22	2.21857e-22	1	0	A	33535075	A	A	33535075	3	1	16	1	0	0	0	0	1	0	0	0	257	739	26	4	323	4	ADAMTS12	5	33535075	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	23285030	33535075	147380185	151	3539											
WDR70	55100	broad.mit.edu	37	chr5	37727134	37727134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acagcccatattgggtttctCcagcatattccaagtgagaa	12	11	8	10	0	1	1	0	1	1	1	3	2	2	1	3	1	2	2	3	1	4	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:37727134C>T	uc003jkv.2	+	17	1922	c.1864C>T	c.(1864-1866)CCA>TCA	p.P622S		NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	622										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGGGTTTCTCCAGCATATTC	0.383													68	88					0	0	0	0	T	37727134	T	T	37727134	3	4	16	1	0	0	0	0	1	0	0	0	17389	855	30	2	1930	2	WDR70	5	37727134	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4192059	37727134	143188126	152	3540											
C9	735	broad.mit.edu	37	chr5	39306836	39306836	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttcaaatgcatattttctGgttccacctcttatgagtga	10	16	7	8	0	3	2	1	2	2	0	4	2	4	2	2	1	1	3	2	1	3	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:39306836G>C	uc003jlv.3	-	9	1388	c.1299C>G	c.(1297-1299)ACC>ACG	p.T433T		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	433	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CATATTTTCTGGTTCCACCTC	0.403													32	73					0	0	0	0	C	39306836	C	C	39306836	2	2	16	1	0	0	0	0	0	0	0	1	2455	1335	47	4		4	C9	5	39306836	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1579702	39306836	141608424	153	3541											
CARD6	84674	broad.mit.edu	37	chr5	40843302	40843302	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctcaatctatgggggcaaGcagtaattcagaagatgctt	12	11	10	8	0	3	2	2	0	1	2	4	2	4	2	1	2	2	4	1	2	5	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:40843302G>C	uc003jmg.2	+	2	407	c.332G>C	c.(331-333)AGC>ACC	p.S111T		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	111					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						ATGGGGGCAAGCAGTAATTCA	0.383													50	83					0	0	0	0	C	40843302	C	C	40843302	3	2	16	1	0	0	0	0	1	0	0	0	2662	971	34	4	338	4	CARD6	5	40843302	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1536466	40843302	140071958	154	3542											
C6	729	broad.mit.edu	37	chr5	41160245	41160245	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atagattcctgatacttactGgatttataatctggagactg	12	15	8	6	0	1	3	0	1	1	2	2	5	2	4	1	2	2	0	1	2	5	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:41160245G>T	uc003jmk.2	-	11	1893	c.1683C>A	c.(1681-1683)TCC>TCA	p.S561S	C6_uc003jml.1_Silent_p.S561S	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	561					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GATACTTACTGGATTTATAAT	0.408													50	94					3.68337e-26	5.39051e-26	1	0	T	41160245	T	T	41160245	2	4	16	1	0	0	0	0	0	0	0	1	2325	1362	47	4		4	C6	5	41160245	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	316943	41160245	139755015	155	3543											
HMGCS1	3157	broad.mit.edu	37	chr5	43298817	43298817	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccagccgcccaatgcaatcaTaggaaaggttatttctctcc	11	10	7	13	1	2	0	1	0	1	0	4	1	3	1	4	2	2	2	4	2	5	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:43298817T>C	uc003jnr.3	-	3	458	c.251A>G	c.(250-252)TAT>TGT	p.Y84C	HMGCS1_uc003jnq.3_Missense_Mutation_p.Y84C	NM_001098272	NP_001091742	Q01581	HMCS1_HUMAN	hydroxymethylglutaryl-CoA synthase 1	84					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity				0						AATGCAATCATAGGAAAGGTT	0.428													70	116					0	0	0	0	C	43298817	C	C	43298817	3	2	16	1	0	0	0	0	1	0	0	0	7271	1406	49	5	1347	5	HMGCS1	5	43298817	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	2138572	43298817	137616443	156	3544											
HCN1	348980	broad.mit.edu	37	chr5	45262356	45262356	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gagagtggcctgacttcccgGgtcaggttggtgttgtgaag	6	11	17	7	1	1	3	1	2	0	1	2	4	2	3	2	4	0	2	2	4	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:45262356G>C	uc003jok.2	-	8	2365	c.2340C>G	c.(2338-2340)ACC>ACG	p.T780T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	780	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TGACTTCCCGGGTCAGGTTGG	0.592													22	61					0	0	0	0	C	45262356	C	C	45262356	2	2	16	1	0	0	0	0	0	0	0	1	7035	1219	43	4		4	HCN1	5	45262356	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1963539	45262356	135652904	157	3545											
HCN1	348980	broad.mit.edu	37	chr5	45396681	45396681	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcatagcaggtggccccGacgatcatgctcagcatggt	9	8	13	11	2	2	0	2	0	0	0	2	2	2	0	2	4	3	4	2	4	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:45396681G>T	uc003jok.2	-	4	1168	c.1143C>A	c.(1141-1143)GTC>GTA	p.V381V		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	381	Helical; Name=Segment S6; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AGGTGGCCCCGACGATCATGC	0.507													18	75					5.03518e-11	6.19492e-11	1	0	T	45396681	T	T	45396681	2	4	16	1	0	0	0	0	0	0	0	1	7035	1045	37	3		3	HCN1	5	45396681	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	134325	45396681	135518579	158	3546											
CDC20B	166979	broad.mit.edu	37	chr5	54442506	54442509	+	Frame_Shift_Del	DEL	GCTT	-	-																															tcttcagcactgatccggaaGcttctgggaggtaggtggtt																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:54442506_54442509delGCTT	uc003jpo.1	-	3	477_480	c.302_305delAAGC	c.(301-306)GAAGCTfs	p.E101fs	CDC20B_uc003jpn.1_Frame_Shift_Del_p.E101fs|CDC20B_uc010ivu.1_Frame_Shift_Del_p.E101fs|CDC20B_uc010ivv.1_Frame_Shift_Del_p.E101fs|CDC20B_uc003jpp.2_RNA	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	101_102											0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			TGATCCGGAAGCTTCTGGGAGGTA	0.529											OREG0016610	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	54442509	-	-	54442506	7	5	16	1	0	1	0	1	0	0	0	0	3075	971	34	0	1294	0	CDC20B	5	54442506	Frame_Shift_Del	DEL	GCTT	TCGA-BA-6869-01A-11D-1870-08	9045825	54442506	126472754	159	3547											
BDP1	55814	broad.mit.edu	37	chr5	70798483	70798483	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctaaaggctttaagacctgtAcaagtgaggggccgattgca	12	9	12	8	1	0	2	0	1	0	1	0	3	0	2	2	3	2	3	2	3	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:70798483A>G	uc003kbp.1	+	15	2369	c.2106A>G	c.(2104-2106)GTA>GTG	p.V702V	BDP1_uc003kbn.1_Silent_p.V702V|BDP1_uc003kbo.2_Silent_p.V702V	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	702					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TAAGACCTGTACAAGTGAGGG	0.383													23	14					0	0	0	0	G	70798483	G	G	70798483	2	3	16	1	0	0	0	0	0	0	0	1	1397	378	14	5		5	BDP1	5	70798483	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	16355977	70798483	110116777	160	3548											
MAP1B	4131	broad.mit.edu	37	chr5	71492996	71492996	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccttagaaaagacccccCtgggtgaacgtagtgtgaac	12	7	10	12	1	0	4	0	2	0	2	0	4	0	4	4	1	2	1	4	1	6	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:71492996C>A	uc003kbw.3	+	5	4055	c.3814C>A	c.(3814-3816)CTG>ATG	p.L1272M	MAP1B_uc010iyw.1_Missense_Mutation_p.L1289M|MAP1B_uc010iyx.1_Missense_Mutation_p.L1146M|MAP1B_uc010iyy.1_Missense_Mutation_p.L1146M	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1272						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AAAGACCCCCCTGGGTGAACG	0.517													51	23					3.86236e-30	5.77103e-30	1	0	A	71492996	A	A	71492996	3	1	16	1	0	0	0	0	1	0	0	0	9281	680	24	4	3832	4	MAP1B	5	71492996	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	694513	71492996	109422264	161	3549											
NSA2	10412	broad.mit.edu	37	chr5	74069717	74069717	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcgtttcaagaaagcccatGtaacacatcctgaactgaaa	15	9	7	10	1	1	3	1	2	0	1	2	3	2	3	2	0	4	2	2	0	5	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:74069717G>C	uc003kdk.1	+	5	630	c.547G>C	c.(547-549)GTA>CTA	p.V183L		NM_014886	NP_055701	O95478	NSA2_HUMAN	NSA2 ribosome biogenesis homolog	183					rRNA processing	nucleolus|ribonucleoprotein complex				ovary(1)	1						GAAAGCCCATGTAACACATCC	0.403													31	20					0	0	0	0	C	74069717	C	C	74069717	3	2	16	1	0	0	0	0	1	0	0	0	10722	1377	48	4	565	4	NSA2	5	74069717	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2576721	74069717	106845543	162	3550											
MEF2C	4208	broad.mit.edu	37	chr5	88119602	88119603	+	Missense_Mutation	DNP	CC	AA	AA																															aatctgaatcttttttctccCcatagtccccgtttttcttc																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:88119602_88119603CC>AA	uc003kjj.2	-	2	676_677	c.3_4GG>TT	c.(1-6)ATGGGG>ATTTGG	p.1_2MG>IW	MEF2C_uc003kji.2_Missense_Mutation_p.1_2MG>IW|MEF2C_uc003kjk.2_Missense_Mutation_p.1_2MG>IW|MEF2C_uc003kjm.2_Missense_Mutation_p.1_2MG>IW|MEF2C_uc003kjl.2_Missense_Mutation_p.1_2MG>IW	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	1_2					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		TTTTTTCTCCCCATAGTCCCCG	0.342										HNSCC(66;0.2)			136	137					0	0	0	0	AA	88119603	AA	AA	88119602	3	1	16	1	0	0	0	0	1	0	0	0	9510	623	22	4	1599	4	MEF2C	5	88119602	Missense_Mutation	DNP	CC	TCGA-BA-6869-01A-11D-1870-08	14049885	88119602	92795658	163	3551											
GPR98	84059	broad.mit.edu	37	chr5	89986666	89986666	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgagtttaactcagtgaaGgtaaacctgccaataattcg	13	11	8	9	1	1	2	1	2	0	0	2	2	1	2	3	1	3	2	3	1	6	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:89986666G>A	uc003kju.2	+	31	6855	c.6759G>A	c.(6757-6759)AAG>AAA	p.K2253K	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2253	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACTCAGTGAAGGTAAACCTGC	0.428													17	10					0	0	0	0	A	89986666	A	A	89986666	2	1	16	1	0	0	0	0	0	0	0	1	6760	991	35	4		4	GPR98	5	89986666	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1867064	89986666	90928594	164	3552											
POU5F2	134187	broad.mit.edu	37	chr5	93076445	93076445	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccggctgtccccacaatctcCcgtggggaagcatcattggt	7	9	11	14	2	2	0	1	0	1	0	4	1	3	1	4	4	1	2	4	4	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:93076445C>T	uc003kkl.1	-	1	865	c.825G>A	c.(823-825)CGG>CGA	p.R275R	FAM172A_uc010jbd.2_Intron|FAM172A_uc011cuf.1_Intron|FAM172A_uc011cug.1_Intron|FAM172A_uc011cuh.1_Intron|FAM172A_uc011cui.1_Intron|FAM172A_uc011cuj.1_Intron	NM_153216	NP_694948	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	275						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		CCACAATCTCCCGTGGGGAAG	0.577													6	16					0	0	0	0	T	93076445	T	T	93076445	2	4	16	1	0	0	0	0	0	0	0	1	12338	610	22	4		4	POU5F2	5	93076445	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3089779	93076445	87838815	165	3553											
LMNB1	4001	broad.mit.edu	37	chr5	126154638	126154638	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagcatgtttggaaaggattCaagaattagaggacttgctt	13	12	12	4	0	1	2	1	0	0	2	1	6	1	5	0	3	2	3	0	3	4	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:126154638C>G	uc003kud.1	+	6	1332	c.964C>G	c.(964-966)CAA>GAA	p.Q322E	LMNB1_uc003kuc.2_Missense_Mutation_p.Q322E|LMNB1_uc010jdb.1_RNA|LMNB1_uc011cxb.1_Missense_Mutation_p.Q112E	NM_005573	NP_005564	P20700	LMNB1_HUMAN	lamin B1	322	Rod.|Coil 2.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			kidney(1)|central_nervous_system(1)	2		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		GGAAAGGATTCAAGAATTAGA	0.388													69	41					0	0	0	0	G	126154638	G	G	126154638	3	3	16	1	0	0	0	0	1	0	0	0	8891	827	29	2	986	2	LMNB1	5	126154638	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	33078193	126154638	54760622	166	3554											
FBN2	2201	broad.mit.edu	37	chr5	127595187	127595187	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcctcattctgagagcctccCcaagctcccctaggaggtag	8	8	10	15	0	2	1	1	1	1	1	4	3	4	2	6	2	2	2	6	2	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:127595187C>A	uc003kuu.2	-	65	9138	c.8699G>T	c.(8698-8700)GGG>GTG	p.G2900V		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2900					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GAGAGCCTCCCCAAGCTCCCC	0.493													62	44					9.53978e-28	1.40899e-27	1	0	A	127595187	A	A	127595187	3	1	16	1	0	0	0	0	1	0	0	0	5735	623	22	4	43	4	FBN2	5	127595187	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1440549	127595187	53320073	167	3555											
FBN2	2201	broad.mit.edu	37	chr5	127702106	127702106	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatacctactccactactacAaaggccgtggaattcagctg	12	9	8	12	1	1	0	1	0	0	0	2	2	2	1	3	2	5	1	3	2	6	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:127702106A>T	uc003kuu.2	-	17	2705	c.2266T>A	c.(2266-2268)TGT>AGT	p.C756S	FBN2_uc003kuv.2_Missense_Mutation_p.C723S	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	756	TB 3.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCACTACTACAAAGGCCGTGG	0.318													19	16					0	0	0	0	T	127702106	T	T	127702106	3	4	16	1	0	0	0	0	1	0	0	0	5735	130	5	5	6668	5	FBN2	5	127702106	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	106919	127702106	53213154	168	3556											
TGFBI	7045	broad.mit.edu	37	chr5	135379745	135379745	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtatggttgtcttgttacAgagtcatcagctacgagtgc	9	14	11	7	1	3	1	2	0	1	1	3	2	3	1	0	1	4	4	0	1	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:135379745A>G	uc003lbf.3	+	3	395	c.234_splice	c.e3-2	p.T78_splice	TGFBI_uc003lbg.3_Splice_Site|TGFBI_uc003lbh.3_Splice_Site|TGFBI_uc011cyb.1_5'Flank	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa						angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTCTTGTTACAGAGTCATCAG	0.537													95	51					0	0	0	0	G	135379745	G	G	135379745	5	3	16	1	0	0	0	0	0	0	1	0	15886	202	7	5	242	5	TGFBI	5	135379745	Splice_Site	SNP	A	TCGA-BA-6869-01A-11D-1870-08	7677639	135379745	45535515	169	3557											
TRPC7	57113	broad.mit.edu	37	chr5	135692763	135692763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcgcgtcccccacccGtgccaggttctccttcttca	5	9	8	19	3	3	0	1	0	2	0	5	0	4	0	5	1	3	2	5	1	0	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:135692763G>A	uc003lbn.1	-	1	313	c.310C>T	c.(310-312)CGG>TGG	p.R104W	TRPC7_uc010jef.1_Missense_Mutation_p.R96W|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.R96W|TRPC7_uc010jei.1_Missense_Mutation_p.R96W|TRPC7_uc010jej.1_Translation_Start_Site	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	105	Cytoplasmic (Potential).|ANK 2.				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCCCCCACCCGTGCCAGGTTC	0.652													37	21					0	0	0	0	A	135692763	A	A	135692763	3	1	16	1	0	0	0	0	1	0	0	0	16651	1144	40	1	2319	1	TRPC7	5	135692763	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	313018	135692763	45222497	170	3558											
PCDHA4	56144	broad.mit.edu	37	chr5	140188125	140188125	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggctgatgtgaacgacaaCgctccggcgttcgcgcagcc	7	7	14	13	6	0	2	0	2	0	0	2	3	1	2	2	2	3	4	2	2	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140188125C>T	uc003lhi.2	+	1	1454	c.1353C>T	c.(1351-1353)AAC>AAT	p.N451N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.N451N|PCDHA4_uc011daa.1_Silent_p.N451N	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACAACGCTCCGGCGT	0.647													62	28					0	0	0	0	T	140188125	T	T	140188125	2	4	16	1	0	0	0	0	0	0	0	1	11580	535	19	1		1	PCDHA4	5	140188125	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4495362	140188125	40727135	171	3559											
PCDHA6	56142	broad.mit.edu	37	chr5	140209711	140209711	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggccaggctccaaaggcgTcatcacgggcgtcggtgggc	6	6	17	12	4	2	0	2	0	0	0	4	0	3	0	2	6	0	1	2	6	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140209711T>A	uc003lho.2	+	1	2062	c.2035T>A	c.(2035-2037)TCA>ACA	p.S679T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.S679T	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	679	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAAAGGCGTCATCACGGGC	0.677													40	29					0	0	0	0	A	140209711	A	A	140209711	3	1	16	1	0	0	0	0	1	0	0	0	11582	1667	58	5	2037	5	PCDHA6	5	140209711	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	21586	140209711	40705549	172	3560											
PCDHA10	56139	broad.mit.edu	37	chr5	140236619	140236619	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agataagggaaacccacctaTggttggtcactgcacggtcc	11	8	11	11	1	1	1	1	0	0	1	2	2	2	2	3	4	2	2	3	4	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140236619T>C	uc003lhx.2	+	1	986	c.986T>C	c.(985-987)ATG>ACG	p.M329T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.M329T|PCDHA10_uc011dad.1_Missense_Mutation_p.M329T	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	329	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCCACCTATGGTTGGTCAC	0.408													34	39					0	0	0	0	C	140236619	C	C	140236619	3	2	16	1	0	0	0	0	1	0	0	0	11574	1464	51	5	988	5	PCDHA10	5	140236619	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	26908	140236619	40678641	173	3561											
PCDHA10	56139	broad.mit.edu	37	chr5	140237225	140237225	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggagctggagctgctacAgttccaggtgagcgcgcgcg	7	6	17	11	5	0	1	0	1	0	0	1	4	1	3	1	3	5	4	1	3	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140237225A>T	uc003lhx.2	+	1	1592	c.1592A>T	c.(1591-1593)CAG>CTG	p.Q531L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.Q531L|PCDHA10_uc011dad.1_Missense_Mutation_p.Q531L	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	531	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTGCTACAGTTCCAGGTG	0.677													80	49					0	0	0	0	T	140237225	T	T	140237225	3	4	16	1	0	0	0	0	1	0	0	0	11574	188	7	5	1594	5	PCDHA10	5	140237225	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	606	140237225	40678035	174	3562											
PCDHA12	56137	broad.mit.edu	37	chr5	140256339	140256339	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagctggtggtgactgcgCgggatgggggctcgccttcg	4	9	19	9	4	0	2	0	2	0	0	2	3	0	3	1	5	2	2	1	5	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140256339C>A	uc003lic.2	+	1	1409	c.1282C>A	c.(1282-1284)CGG>AGG	p.R428R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.R428R	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	428	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGACTGCGCGGGATGGGGG	0.637													124	76					1.15969e-64	1.78692e-64	1	0	A	140256339	A	A	140256339	2	1	16	1	0	0	0	0	0	0	0	1	11576	759	27	3		3	PCDHA12	5	140256339	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	19114	140256339	40658921	175	3563											
PCDHB3	56132	broad.mit.edu	37	chr5	140480891	140480891	+	Frame_Shift_Del	DEL	C	-	-																															ccgcgctggacggcggctctCcccctcggtctgggacagcc																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140480891delC	uc003lio.2	+	1	658	c.658delC	c.(658-660)CCCfs	p.P220fs	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	220	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGCGGCTCTCCCCCTCGGTC	0.552													---	---	---								-	140480891	-	-	140480891	7	5	16	1	0	1	0	1	0	0	0	0	11597	855	30	0	660	0	PCDHB3	5	140480891	Frame_Shift_Del	DEL	C	TCGA-BA-6869-01A-11D-1870-08	224552	140480891	40434369	176	3564											
PCDHB7	56129	broad.mit.edu	37	chr5	140554035	140554035	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagaccgcggctcccccgCgctgagcagcgaggcgctgg	6	3	15	17	6	0	2	0	1	0	1	1	3	1	2	3	3	2	4	3	3	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140554035C>T	uc003lit.2	+	1	1793	c.1619C>T	c.(1618-1620)GCG>GTG	p.A540V		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	540	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCTCCCCCGCGCTGAGCAGC	0.697													45	32					0	0	0	0	T	140554035	T	T	140554035	3	4	16	1	0	0	0	0	1	0	0	0	11601	768	27	1	1621	1	PCDHB7	5	140554035	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	73144	140554035	40361225	177	3565											
PCDHGA7	56108	broad.mit.edu	37	chr5	140762824	140762824	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgaatctttaccctataGacgtggaaataatagatatt	17	13	6	5	1	1	3	0	1	1	2	1	4	1	4	1	1	1	0	1	1	9	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:140762824G>T	uc003lka.1	+	1	358	c.358G>T	c.(358-360)GAC>TAC	p.D120Y	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.D120Y	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	120	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTACCCTATAGACGTGGAAAT	0.418													60	37					7.50695e-29	1.11646e-28	1	0	T	140762824	T	T	140762824	3	4	16	1	0	0	0	0	1	0	0	0	11613	942	33	2	360	2	PCDHGA7	5	140762824	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	208789	140762824	40152436	178	3566											
PPP2R2B	5521	broad.mit.edu	37	chr5	146017900	146017900	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctgtacacgaaggtgttgCaatgatgggggtggaactcg	9	10	16	6	2	0	1	0	1	0	0	1	3	0	2	0	4	4	4	0	4	4	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:146017900C>G	uc003loe.2	-	6	1229	c.704G>C	c.(703-705)TGC>TCC	p.C235S	PPP2R2B_uc010jgm.2_Missense_Mutation_p.C224S|PPP2R2B_uc003log.3_Missense_Mutation_p.C235S|PPP2R2B_uc003lof.3_Missense_Mutation_p.C235S|PPP2R2B_uc003loi.3_Missense_Mutation_p.C238S|PPP2R2B_uc003loh.3_Missense_Mutation_p.C235S|PPP2R2B_uc003loj.3_Missense_Mutation_p.C215S|PPP2R2B_uc003lok.3_Missense_Mutation_p.C224S|PPP2R2B_uc011dbu.1_Missense_Mutation_p.C241S|PPP2R2B_uc011dbv.1_Missense_Mutation_p.C293S	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	235	WD 4.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAAGGTGTTGCAATGATGGGG	0.542													43	21					0	0	0	0	G	146017900	G	G	146017900	3	3	16	1	0	0	0	0	1	0	0	0	12445	710	25	4	643	4	PPP2R2B	5	146017900	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	5255076	146017900	34897360	179	3567											
NSD1	64324	broad.mit.edu	37	chr5	176637520	176637520	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagcctctcattagtaactCacatacagaccacttaatgg	14	10	6	11	0	2	1	2	0	1	1	3	2	2	1	2	1	3	1	2	1	5	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr5:176637520C>G	uc003mfr.3	+	5	2258	c.2120C>G	c.(2119-2121)TCA>TGA	p.S707*	NSD1_uc003mft.3_Nonsense_Mutation_p.S438*|NSD1_uc003mfs.1_Nonsense_Mutation_p.S604*|NSD1_uc011dfx.1_Nonsense_Mutation_p.S355*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	707					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ATTAGTAACTCACATACAGAC	0.403			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			43	25					0	0	0	0	G	176637520	G	G	176637520	4	3	16	1	0	0	0	0	0	1	0	0	10723	838	29	2	2134	2	NSD1	5	176637520	Nonsense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	30619620	176637520	4277740	180	3568											
RNF182	221687	broad.mit.edu	37	chr6	13977639	13977639	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acttgacttgtggaggcaaaGggaagaagtgcctgccagag	12	7	15	7	0	0	3	0	1	0	2	0	5	0	5	2	3	2	1	2	3	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:13977639G>A	uc003nbe.2	+	3	707	c.289G>A	c.(289-291)GGG>AGG	p.G97R	RNF182_uc003nbf.2_Missense_Mutation_p.G97R|RNF182_uc003nbg.2_Missense_Mutation_p.G97R	NM_152737	NP_689950	Q8N6D2	RN182_HUMAN	ring finger protein 182	97						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			TGGAGGCAAAGGGAAGAAGTG	0.542													58	84					0	0	0	0	A	13977639	A	A	13977639	3	1	16	1	0	0	0	0	1	0	0	0	13531	1000	35	4	291	4	RNF182	6	13977639	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08		13977639	157137428	181	3569											
GPLD1	2822	broad.mit.edu	37	chr6	24473885	24473885	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcctctgaataggagccgTgaaaatcaatctaagaaaga	17	7	10	7	1	3	4	1	2	2	2	3	6	3	5	2	1	2	0	2	1	7	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:24473885T>A	uc003ned.1	-	6	563	c.452A>T	c.(451-453)CAC>CTC	p.H151L	GPLD1_uc010jpr.1_Intron|GPLD1_uc010jps.1_Missense_Mutation_p.H151L|GPLD1_uc003nee.2_Missense_Mutation_p.H151L	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	151						extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						ATAGGAGCCGTGAAAATCAAT	0.393													22	15					0	0	0	0	A	24473885	A	A	24473885	3	1	16	1	0	0	0	0	1	0	0	0	6652	1696	59	5	2191	5	GPLD1	6	24473885	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	10496246	24473885	146641182	182	3570											
SLC17A1	6568	broad.mit.edu	37	chr6	25830751	25830751	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggaacagaataaagtgctaCcttttttgggaggcaaccgg	12	10	12	7	1	0	1	0	0	0	1	0	3	0	3	2	4	4	2	2	4	6	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:25830751C>T	uc003nfh.3	-	2	150	c.34_splice	c.e2+1	p.V12_splice	SLC17A1_uc011djy.1_Intron|SLC17A1_uc010jqb.1_Splice_Site_p.V10_splice|SLC17A1_uc010jqc.1_Intron	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),						sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						TAAAGTGCTACCTTTTTTGGG	0.398													66	73					0	0	0	0	T	25830751	T	T	25830751	5	4	16	1	0	0	0	0	0	0	1	0	14481	521	18	4	1412	4	SLC17A1	6	25830751	Splice_Site	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1356866	25830751	145284316	183	3571											
HIST1H3D	8351	broad.mit.edu	37	chr6	26197203	26197203	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctcgcaggcctcctgcagCgccatcaccgccgagctctg	5	6	11	19	4	2	0	1	0	1	0	4	1	3	0	6	1	3	3	6	1	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:26197203C>A	uc003ngv.2	-	2	673	c.276G>T	c.(274-276)GCG>GCT	p.A92A	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	92					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				CCTCCTGCAGCGCCATCACCG	0.587													31	99					2.08457e-15	2.77798e-15	1	0	A	26197203	A	A	26197203	2	1	16	1	0	0	0	0	0	0	0	1	7197	755	27	3		3	HIST1H3D	6	26197203	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	366452	26197203	144917864	184	3572											
HIST1H1B	3009	broad.mit.edu	37	chr6	27835170	27835170	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagccacagccttggtgatCagctctgagactgggggccc	7	7	14	13	0	2	2	1	2	1	1	2	3	2	2	3	3	3	2	3	3	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:27835170C>T	uc003njx.2	-	1	190	c.138G>A	c.(136-138)CTG>CTA	p.L46L		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	46	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CCTTGGTGATCAGCTCTGAGA	0.602													25	87					0	0	0	0	T	27835170	T	T	27835170	2	4	16	1	0	0	0	0	0	0	0	1	7162	813	29	2		2	HIST1H1B	6	27835170	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1637967	27835170	143279897	185	3573											
OR11A1	26531	broad.mit.edu	37	chr6	29394860	29394860	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggatccgagcaagccaggcCcacgaaaagcataaagtcac	15	3	11	12	2	1	0	1	0	0	0	2	3	2	1	3	2	3	2	3	2	5	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:29394860C>A	uc003nmg.2	-	1	650	c.559G>T	c.(559-561)GGC>TGC	p.G187C		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CAAGCCAGGCCCACGAAAAGC	0.507													21	14					2.89027e-11	3.56281e-11	1	0	A	29394860	A	A	29394860	3	1	16	1	0	0	0	0	1	0	0	0	10978	623	22	4	392	4	OR11A1	6	29394860	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1559690	29394860	141720207	186	3574											
DNAH8	1769	broad.mit.edu	37	chr6	38905924	38905924	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcctctacttcctcatcaCagagatgagcatggtcaaca	12	10	6	13	0	4	2	3	1	1	1	6	3	6	2	2	1	3	1	2	1	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:38905924C>A	uc003ooe.1	+	76	11687	c.11087C>A	c.(11086-11088)ACA>AAA	p.T3696K	DNAH8_uc003oog.1_Missense_Mutation_p.T145K|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTCCTCATCACAGAGATGAGC	0.522													52	25					1.21353e-23	1.74021e-23	1	0	A	38905924	A	A	38905924	3	1	16	1	0	0	0	0	1	0	0	0	4629	478	17	4	11381	4	DNAH8	6	38905924	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	9511064	38905924	132209143	187	3575											
DAAM2	23500	broad.mit.edu	37	chr6	39864638	39864638	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcaagcgtcttagacagAtgctagaggtcatcctagcc	11	8	11	11	1	2	3	1	0	1	3	3	3	3	3	2	1	4	3	2	1	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:39864638A>T	uc003oow.2	+	20	2548	c.2392A>T	c.(2392-2394)ATG>TTG	p.M798L	DAAM2_uc003oox.2_Missense_Mutation_p.M798L	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	798	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					TCTTAGACAGATGCTAGAGGT	0.622													18	8					0	0	0	0	T	39864638	T	T	39864638	3	4	16	1	0	0	0	0	1	0	0	0	4233	333	12	5	2466	5	DAAM2	6	39864638	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	958714	39864638	131250429	188	3576											
CUL9	23113	broad.mit.edu	37	chr6	43170895	43170895	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatcctcttggagaacctgAaccgcttctggcccatcatc	8	11	8	14	1	3	3	1	2	2	1	5	4	4	3	4	2	2	1	4	2	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:43170895A>G	uc003ouk.2	+	18	3877	c.3802A>G	c.(3802-3804)AAC>GAC	p.N1268D	CUL9_uc003oul.2_Missense_Mutation_p.N1268D|CUL9_uc010jyk.2_Missense_Mutation_p.N420D	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1268	DOC.			N -> S (in Ref. 3; CAH18328).	ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GGAGAACCTGAACCGCTTCTG	0.577													23	28					0	0	0	0	G	43170895	G	G	43170895	3	3	16	1	0	0	0	0	1	0	0	0	4078	246	9	5	3868	5	CUL9	6	43170895	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	3306257	43170895	127944172	189	3577											
HMGCLL1	54511	broad.mit.edu	37	chr6	55443753	55443753	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgcgaggtggtacctgcgcgGggtcgagcgcccctgccact	4	6	16	15	6	0	0	0	0	0	0	1	2	0	0	4	4	4	1	4	4	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:55443753G>T	uc003pcn.2	-	1	260	c.101C>A	c.(100-102)CCC>CAC	p.P34H	HMGCLL1_uc003pco.2_Missense_Mutation_p.P34H|HMGCLL1_uc010jzx.2_5'UTR|HMGCLL1_uc011dxc.1_Missense_Mutation_p.P34H|HMGCLL1_uc011dxd.1_Missense_Mutation_p.P34H|HMGCLL1_uc011dxe.1_Missense_Mutation_p.P34H|HMGCLL1_uc003pcp.2_Missense_Mutation_p.P34H	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	34							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			TACCTGCGCGGGGTCGAGCGC	0.647													5	3					1.024e-07	1.15764e-07	1	0	T	55443753	T	T	55443753	3	4	16	1	0	0	0	0	1	0	0	0	7269	1232	43	4	1051	4	HMGCLL1	6	55443753	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	12272858	55443753	115671314	190	3578											
BAI3	577	broad.mit.edu	37	chr6	69666697	69666697	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agatgcaatgagcagcgatgCcctggtgagaatgaacccaa	14	6	12	9	1	0	4	0	3	0	2	0	6	0	4	2	1	5	2	2	1	4	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:69666697C>A	uc003pev.3	+	8	1969	c.1521C>A	c.(1519-1521)TGC>TGA	p.C507*	BAI3_uc010kak.2_Nonsense_Mutation_p.C507*	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	507	TSP type-1 4.|Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AGCAGCGATGCCCTGGTGAGA	0.423													39	30					1.49673e-21	2.10858e-21	1	0	A	69666697	A	A	69666697	4	1	16	1	0	0	0	0	0	1	0	0	1302	747	26	4	1543	4	BAI3	6	69666697	Nonsense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	14222944	69666697	101448370	191	3579											
TBX18	9096	broad.mit.edu	37	chr6	85446515	85446515	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaggtgcactccttccacaGggggcaacatctgccgatcc	8	7	11	15	1	1	0	0	0	1	0	4	1	4	0	4	3	3	3	4	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:85446515G>T	uc003pkl.1	-	8	1712	c.1712C>A	c.(1711-1713)CCT>CAT	p.P571H	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	571					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		TCCTTCCACAGGGGGCAACAT	0.522													40	18					4.0492e-12	5.09929e-12	1	0	T	85446515	T	T	85446515	3	4	16	1	0	0	0	0	1	0	0	0	15719	1000	35	4	115	4	TBX18	6	85446515	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	15779818	85446515	85668552	192	3580											
GPR63	81491	broad.mit.edu	37	chr6	97246760	97246760	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctggcctggctgaggcatAtaccttcagggtagctatgg	7	11	14	9	0	1	1	1	1	0	0	1	1	1	1	2	5	3	5	2	5	4	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:97246760A>G	uc010kcl.2	-	3	1326	c.848T>C	c.(847-849)ATA>ACA	p.I283T	GPR63_uc003pou.2_Missense_Mutation_p.I283T	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	283	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		GCTGAGGCATATACCTTCAGG	0.473													47	24					0	0	0	0	G	97246760	G	G	97246760	3	3	16	1	0	0	0	0	1	0	0	0	6742	449	16	5	415	5	GPR63	6	97246760	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	11800245	97246760	73868307	193	3581											
PRDM1	639	broad.mit.edu	37	chr6	106547326	106547326	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catctacttctacaccattaAgcccatccctgccaaccagg	11	9	4	17	0	2	0	0	0	2	0	3	0	3	0	5	1	5	0	5	1	4	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:106547326A>T	uc003prd.2	+	4	797	c.563A>T	c.(562-564)AAG>ATG	p.K188M	PRDM1_uc003pre.2_Missense_Mutation_p.K54M	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	188	SET.				negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		TACACCATTAAGCCCATCCCT	0.502			D|N|Mis|F|S		DLBCL								27	30					0	0	0	0	T	106547326	T	T	106547326	3	4	16	1	0	0	0	0	1	0	0	0	12512	72	3	5	590	5	PRDM1	6	106547326	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	9300566	106547326	64567741	194	3582											
GPRC6A	222545	broad.mit.edu	37	chr6	117127963	117127963	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcagttgaccaattatcaCtagcaatccacatcttattt	12	14	5	10	0	2	1	1	1	1	0	3	1	3	1	2	1	1	3	2	1	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:117127963C>A	uc003pxj.1	-	3	927	c.905G>T	c.(904-906)AGT>ATT	p.S302I	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Missense_Mutation_p.S302I	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	302	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CCAATTATCACTAGCAATCCA	0.363													44	41					9.39024e-22	1.3258e-21	1	0	A	117127963	A	A	117127963	3	1	16	1	0	0	0	0	1	0	0	0	6767	565	20	4	1891	4	GPRC6A	6	117127963	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	10580637	117127963	53987104	195	3583											
ENPP3	5169	broad.mit.edu	37	chr6	132043384	132043384	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagatcttctacgcattcaaCcagcaccaaacaatggaacc	15	7	5	14	1	3	1	1	0	2	1	3	2	3	2	3	1	5	2	3	1	5	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:132043384C>A	uc003qcu.3	+	19	1932	c.1585C>A	c.(1585-1587)CCA>ACA	p.P529T	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.P529T	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	529	Extracellular (Potential).				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		ACGCATTCAACCAGCACCAAA	0.408													29	23					3.67414e-24	5.30433e-24	1	0	A	132043384	A	A	132043384	3	1	16	1	0	0	0	0	1	0	0	0	5155	507	18	4	1655	4	ENPP3	6	132043384	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	14915421	132043384	39071683	196	3584											
TAAR9	134860	broad.mit.edu	37	chr6	132859539	132859539	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcgatctatcctctacgcCgtccttggttttggggctgt	3	15	10	13	3	2	0	0	0	2	0	5	1	4	0	4	3	1	2	4	3	2	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:132859539C>T	uc011eci.1	+	1	113	c.111C>T	c.(109-111)GCC>GCT	p.A37A		NM_175057	NP_778227	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9	37	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity				0	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		TCCTCTACGCCGTCCTTGGTT	0.478													33	17					0	0	0	0	T	132859539	T	T	132859539	2	4	16	1	0	0	0	0	0	0	0	1	15560	639	23	1		1	TAAR9	6	132859539	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	816155	132859539	38255528	197	3585											
GRM1	2911	broad.mit.edu	37	chr6	146755793	146755793	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctgcgctgacgcctccgtCgcctttccgcgactcggtgg	2	9	13	17	7	0	1	0	1	0	0	4	2	2	1	5	2	1	1	5	2	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:146755793C>T	uc010khw.1	+	9	3916	c.3446C>T	c.(3445-3447)TCG>TTG	p.S1149L	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1149	Ser-rich.|Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ACGCCTCCGTCGCCTTTCCGC	0.657													5	43					0	0	0	0	T	146755793	T	T	146755793	3	4	16	1	0	0	0	0	1	0	0	0	6835	893	31	1	3541	1	GRM1	6	146755793	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	13896254	146755793	24359274	198	3586											
SASH1	23328	broad.mit.edu	37	chr6	148867161	148867161	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctggcagcatggccgctGtgggattcctgaagccctgg	5	9	14	13	1	0	1	0	1	0	0	2	2	2	2	4	4	2	3	4	4	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:148867161G>T	uc003qme.1	+	19	3834	c.3359G>T	c.(3358-3360)TGT>TTT	p.C1120F	SASH1_uc003qmf.1_Missense_Mutation_p.C530F	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	1120							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CATGGCCGCTGTGGGATTCCT	0.498													39	19					1.7489e-18	2.3954e-18	1	0	T	148867161	T	T	148867161	3	4	16	1	0	0	0	0	1	0	0	0	13913	1377	48	4	3433	4	SASH1	6	148867161	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2111368	148867161	22247906	199	3587											
LATS1	9113	broad.mit.edu	37	chr6	150005102	150005102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agctgctgtcagaggatatgGaggtggtggctgccgattca	8	10	16	7	1	2	1	2	0	0	1	2	4	2	3	1	5	3	3	1	5	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:150005102G>A	uc003qmu.1	-	4	1671	c.1123C>T	c.(1123-1125)CCA>TCA	p.P375S	LATS1_uc010kif.1_Missense_Mutation_p.P270S|LATS1_uc003qmv.1_Missense_Mutation_p.P375S|LATS1_uc003qmw.2_Missense_Mutation_p.P375S|LATS1_uc010kig.1_Missense_Mutation_p.P270S	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	375	PPxY motif 1.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AGAGGATATGGAGGTGGTGGC	0.478													40	30					0	0	0	0	A	150005102	A	A	150005102	3	1	16	1	0	0	0	0	1	0	0	0	8686	1174	41	2	2289	2	LATS1	6	150005102	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1137941	150005102	21109965	200	3588											
SYNE1	23345	broad.mit.edu	37	chr6	152605236	152605236	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcacaagactcggatacCagctcctctgcgagagagga	11	6	11	13	2	2	2	1	0	1	2	4	6	3	4	3	2	3	1	3	2	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:152605236C>G	uc010kiw.2	-	96	18686	c.18084G>C	c.(18082-18084)CTG>CTC	p.L6028L	SYNE1_uc010kiv.2_Silent_p.L552L|SYNE1_uc003qos.3_Silent_p.L552L|SYNE1_uc003qot.3_Silent_p.L5957L|SYNE1_uc003qou.3_Silent_p.L6028L|SYNE1_uc010kiy.1_Silent_p.L207L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6028	Spectrin 20.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACTCGGATACCAGCTCCTCTG	0.542										HNSCC(10;0.0054)			35	25					0	0	0	0	G	152605236	G	G	152605236	2	3	16	1	0	0	0	0	0	0	0	1	15511	581	21	4		4	SYNE1	6	152605236	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2600134	152605236	18509831	201	3589											
SYNE1	23345	broad.mit.edu	37	chr6	152631122	152631122	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgcactgcttgcaccttcgGcttcagtgactccatctcag	6	12	8	15	1	2	1	2	1	1	0	5	1	3	1	2	1	3	4	2	1	0	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:152631122G>A	uc010kiw.2	-	90	17652	c.17050C>T	c.(17050-17052)CCG>TCG	p.P5684S	SYNE1_uc010kiv.2_Missense_Mutation_p.P208S|SYNE1_uc003qos.3_Missense_Mutation_p.P208S|SYNE1_uc003qot.3_Missense_Mutation_p.P5613S|SYNE1_uc003qou.3_Missense_Mutation_p.P5684S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5684	Spectrin 18.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCACCTTCGGCTTCAGTGAC	0.448										HNSCC(10;0.0054)			30	19					0	0	0	0	A	152631122	A	A	152631122	3	1	16	1	0	0	0	0	1	0	0	0	15511	1203	42	4	9644	4	SYNE1	6	152631122	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	25886	152631122	18483945	202	3590											
VIP	7432	broad.mit.edu	37	chr6	153077303	153077303	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagaccctgtaccagtcaaaCgtcactcagatgcagtcttc	12	9	7	13	1	4	2	3	0	1	2	5	2	4	2	2	0	3	2	2	0	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:153077303C>A	uc003qpe.2	+	5	542	c.370C>A	c.(370-372)CGT>AGT	p.R124S	VIP_uc003qpf.2_Missense_Mutation_p.R123S|VIP_uc010kjd.2_Missense_Mutation_p.R123S	NM_003381	NP_003372	P01282	VIP_HUMAN	vasoactive intestinal peptide isoform 1	124					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity				0		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		ACCAGTCAAACGTCACTCAGA	0.383													67	43					1.93348e-29	2.88223e-29	1	0	A	153077303	A	A	153077303	3	1	16	1	0	0	0	0	1	0	0	0	17235	536	19	3	384	3	VIP	6	153077303	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	446181	153077303	18037764	203	3591											
SLC22A2	6582	broad.mit.edu	37	chr6	160668217	160668217	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttaaggccctggctcaccTgaagggaggcgggtagagat	10	7	15	9	1	1	2	1	1	0	1	1	4	1	3	2	5	0	2	2	5	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr6:160668217T>G	uc003qtf.2	-	5	1126	c.956A>C	c.(955-957)CAG>CCG	p.Q319P	SLC22A2_uc003qte.1_Missense_Mutation_p.Q319P	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	319	Cytoplasmic (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CTGGCTCACCTGAAGGGAGGC	0.488													50	27					0	0	0	0	G	160668217	G	G	160668217	3	3	16	1	0	0	0	0	1	0	0	0	14515	1594	55	5	739	5	SLC22A2	6	160668217	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	7590914	160668217	10446850	204	3592											
MAD1L1	8379	broad.mit.edu	37	chr7	1937853	1937853	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccttgaagatgaggcagtCgcctgggtgctcggcgtaca	8	8	14	11	3	0	3	0	2	0	1	2	3	0	3	2	3	2	3	2	3	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:1937853C>T	uc003slh.1	-	18	2247	c.1981G>A	c.(1981-1983)GAC>AAC	p.D661N	MAD1L1_uc003sle.1_Missense_Mutation_p.D390N|MAD1L1_uc003slf.1_Missense_Mutation_p.D661N|MAD1L1_uc003slg.1_Missense_Mutation_p.D661N|MAD1L1_uc010ksh.1_Missense_Mutation_p.D661N|MAD1L1_uc003sli.1_Missense_Mutation_p.D569N|MAD1L1_uc010ksi.1_Missense_Mutation_p.D614N|MAD1L1_uc010ksj.2_Missense_Mutation_p.D661N|MAD1L1_uc003sld.1_Missense_Mutation_p.D117N	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	661					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		ATGAGGCAGTCGCCTGGGTGC	0.627													4	9					0	0	0	0	T	1937853	T	T	1937853	3	4	16	1	0	0	0	0	1	0	0	0	9198	884	31	1	183	1	MAD1L1	7	1937853	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08		1937853	157200810	205	3593											
DGKB	1607	broad.mit.edu	37	chr7	14722240	14722240	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtaacatttaacagttttgtGgcacttatcacacttggttg	10	16	8	7	0	1	0	1	0	0	0	1	0	1	0	0	2	2	4	0	2	3	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:14722240G>T	uc003ssz.2	-	11	1160	c.973C>A	c.(973-975)CAC>AAC	p.H325N	DGKB_uc011jxt.1_Missense_Mutation_p.H318N|DGKB_uc003sta.2_Missense_Mutation_p.H325N|DGKB_uc011jxu.1_Missense_Mutation_p.H325N	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	325	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	ACAGTTTTGTGGCACTTATCA	0.423													40	93					1.48646e-12	1.89052e-12	1	0	T	14722240	T	T	14722240	3	4	16	1	0	0	0	0	1	0	0	0	4488	1348	47	4	1516	4	DGKB	7	14722240	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	12784387	14722240	144416423	206	3594											
PRPS1L1	221823	broad.mit.edu	37	chr7	18067285	18067285	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actctcatcaatttccacgcAggtctcctggttgctgaatt	8	14	7	12	1	3	1	2	1	2	0	6	1	4	1	2	2	1	3	2	2	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:18067285A>T	uc003stz.2	-	1	202	c.121T>A	c.(121-123)TGC>AGC	p.C41S		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	41					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					ATTTCCACGCAGGTCTCCTGG	0.512													65	138					0	0	0	0	T	18067285	T	T	18067285	3	4	16	1	0	0	0	0	1	0	0	0	12641	188	7	5	839	5	PRPS1L1	7	18067285	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	3345045	18067285	141071378	207	3595											
CRHR2	1395	broad.mit.edu	37	chr7	30706845	30706845	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaggtgagggccactcaccTtgtcatccaaaatgggctca	10	8	11	12	0	3	1	3	1	0	0	4	1	4	1	3	3	0	2	3	3	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:30706845T>C	uc003tbn.2	-	3	558	c.314A>G	c.(313-315)AAG>AGG	p.K105R	CRHR2_uc010kvw.1_Missense_Mutation_p.K105R|CRHR2_uc010kvx.1_Missense_Mutation_p.K105R|CRHR2_uc010kvy.1_Intron|CRHR2_uc003tbo.2_Missense_Mutation_p.K91R|CRHR2_uc003tbp.2_Missense_Mutation_p.K132R	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	105	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						GCCACTCACCTTGTCATCCAA	0.517													15	47					0	0	0	0	C	30706845	C	C	30706845	3	2	16	1	0	0	0	0	1	0	0	0	3887	1623	56	5	961	5	CRHR2	7	30706845	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	12639560	30706845	128431818	208	3596											
CCDC129	223075	broad.mit.edu	37	chr7	31683113	31683113	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagctccaggtctgtaatgaCccagatgtcctccagcctgg	8	9	10	14	0	1	2	0	1	1	1	4	2	4	2	5	2	2	2	5	2	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:31683113C>T	uc003tcj.1	+	11	3122	c.2129C>T	c.(2128-2130)ACC>ATC	p.T710I	CCDC129_uc011kad.1_Missense_Mutation_p.T720I|CCDC129_uc003tci.1_Missense_Mutation_p.T561I|CCDC129_uc011kae.1_Missense_Mutation_p.T736I|CCDC129_uc003tck.1_Missense_Mutation_p.T618I	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	710											0						TCTGTAATGACCCAGATGTCC	0.522													25	45					0	0	0	0	T	31683113	T	T	31683113	3	4	16	1	0	0	0	0	1	0	0	0	2776	507	18	4	2167	4	CCDC129	7	31683113	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	976268	31683113	127455550	209	3597											
PDE1C	5137	broad.mit.edu	37	chr7	32209472	32209472	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaggatctcctctgggggtCgagggtcatggacaattgtt	7	12	14	8	1	3	0	1	0	2	0	5	3	3	2	1	5	0	1	1	5	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:32209472C>A	uc003tco.1	-	3	827	c.233G>T	c.(232-234)CGA>CTA	p.R78L		NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	Error:Variant_position_missing_in_Q14123_after_alignment					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CTCTGGGGGTCGAGGGTCATG	0.507													29	64					1.04594e-18	1.43565e-18	1	0	A	32209472	A	A	32209472	3	1	16	1	0	0	0	0	1	0	0	0	11689	899	31	3		3	PDE1C	7	32209472	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	526359	32209472	126929191	210	3598											
NPSR1	387129	broad.mit.edu	37	chr7	34889223	34889223	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacgttccgggagagaactGagaggcatgagatgcagatt	12	8	15	6	2	0	5	0	3	0	4	1	9	1	6	1	2	2	3	1	2	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:34889223G>A	uc003teg.1	+	9	1200	c.1072G>A	c.(1072-1074)GAG>AAG	p.E358K	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Silent_p.*391*|NPSR1_uc010kwt.1_Missense_Mutation_p.E205K|NPSR1_uc010kwu.1_Missense_Mutation_p.E148K|NPSR1_uc010kwv.1_Missense_Mutation_p.E292K|NPSR1_uc003tei.1_Intron|NPSR1_uc010kww.1_Intron|NPSR1_uc011kar.1_Intron	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	358	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	GGAGAGAACTGAGAGGCATGA	0.488													40	80					0	0	0	0	A	34889223	A	A	34889223	3	1	16	1	0	0	0	0	1	0	0	0	10654	1291	45	2	1106	2	NPSR1	7	34889223	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2679751	34889223	124249440	211	3599											
TXNDC3	51314	broad.mit.edu	37	chr7	37903952	37903952	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttctaaatttttttccagagGaattatacagtattgctatt	12	19	5	5	0	1	1	0	0	1	1	2	2	2	2	1	1	2	2	1	1	7	11			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:37903952G>A	uc003tfn.2	+	9	829	c.457G>A	c.(457-459)GAA>AAA	p.E153K		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	153					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TTTTCCAGAGGAATTATACAG	0.284									Kartagener_syndrome				12	24					0	0	0	0	A	37903952	A	A	37903952	3	1	16	1	0	0	0	0	1	0	0	0	16866	1175	41	2	483	2	TXNDC3	7	37903952	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3014729	37903952	121234711	212	3600											
ADCY1	107	broad.mit.edu	37	chr7	45697343	45697343	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagatctgtggctgaagccaCcgaggtggatctgaacatgc	10	8	13	10	1	2	3	0	2	2	1	2	5	2	4	2	3	3	1	2	3	2	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:45697343C>A	uc003tne.3	+	6	1184	c.1166C>A	c.(1165-1167)ACC>AAC	p.T389N	ADCY1_uc003tnd.2_Missense_Mutation_p.T164N	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	389	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCTGAAGCCACCGAGGTGGAT	0.607													5	15					1.23904e-05	1.32813e-05	1	0	A	45697343	A	A	45697343	3	1	16	1	0	0	0	0	1	0	0	0	292	507	18	4	1188	4	ADCY1	7	45697343	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	7793391	45697343	113441320	213	3601											
TNS3	64759	broad.mit.edu	37	chr7	47333420	47333420	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacgagttcattggccaaaTctccagctgtggcaagaaat	12	9	11	9	1	2	1	1	0	1	1	3	3	2	2	2	3	1	3	2	3	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:47333420T>C	uc003tnv.2	-	25	4050	c.3683A>G	c.(3682-3684)GAT>GGT	p.D1228G	TNS3_uc003tnw.2_Missense_Mutation_p.D1228G	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	1228	SH2.					focal adhesion	protein binding			ovary(4)	4						ATTGGCCAAATCTCCAGCTGT	0.438													28	50					0	0	0	0	C	47333420	C	C	47333420	3	2	16	1	0	0	0	0	1	0	0	0	16410	1435	50	5	682	5	TNS3	7	47333420	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	1636077	47333420	111805243	214	3602											
TNS3	64759	broad.mit.edu	37	chr7	47408232	47408232	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccattcacaacctggtctcCtggaaacctgggtttgaacg	9	11	9	12	1	2	1	1	1	1	0	4	2	3	2	4	3	3	1	4	3	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:47408232C>T	uc003tnv.2	-	17	2378	c.2011G>A	c.(2011-2013)GGA>AGA	p.G671R	TNS3_uc003tnw.2_Missense_Mutation_p.G671R	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	671						focal adhesion	protein binding			ovary(4)	4						ACCTGGTCTCCTGGAAACCTG	0.632													60	113					0	0	0	0	T	47408232	T	T	47408232	3	4	16	1	0	0	0	0	1	0	0	0	16410	690	24	4	2386	4	TNS3	7	47408232	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	74812	47408232	111730431	215	3603											
PKD1L1	168507	broad.mit.edu	37	chr7	47894539	47894539	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggaaaattcaatttctatCtgtagagattcctgggggtt	10	16	10	5	0	3	1	1	0	2	1	4	3	4	2	1	3	0	2	1	3	5	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:47894539C>G	uc003tny.1	-	30	4800	c.4800G>C	c.(4798-4800)CAG>CAC	p.Q1600H		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1600	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CAATTTCTATCTGTAGAGATT	0.398													31	63					0	0	0	0	G	47894539	G	G	47894539	3	3	16	1	0	0	0	0	1	0	0	0	12019	912	32	2	3861	2	PKD1L1	7	47894539	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	486307	47894539	111244124	216	3604											
ABCA13	154664	broad.mit.edu	37	chr7	48285513	48285513	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtttctctgagaaggaggtCtttttgccgcctggaaactc	7	13	11	10	2	2	1	0	1	2	1	4	4	2	3	2	3	2	1	2	3	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:48285513C>A	uc003toq.2	+	13	1570	c.1545C>A	c.(1543-1545)GTC>GTA	p.V515V	ABCA13_uc010kyr.2_Silent_p.V18V	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	515					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AGAAGGAGGTCTTTTTGCCGC	0.448													15	37					6.72482e-11	8.22636e-11	1	0	A	48285513	A	A	48285513	2	1	16	1	0	0	0	0	0	0	0	1	31	900	32	2		2	ABCA13	7	48285513	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	390974	48285513	110853150	217	3605											
ABCA13	154664	broad.mit.edu	37	chr7	48318403	48318403	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtttcggggaagatgtccAcagtttttaaaactcatttt	12	15	8	6	1	1	1	1	0	0	1	3	2	2	2	1	2	1	2	1	2	4	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:48318403A>T	uc003toq.2	+	18	7637	c.7612A>T	c.(7612-7614)ACA>TCA	p.T2538S	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2538					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GAAGATGTCCACAGTTTTTAA	0.393													55	134					0	0	0	0	T	48318403	T	T	48318403	3	4	16	1	0	0	0	0	1	0	0	0	31	159	6	5	7511	5	ABCA13	7	48318403	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	32890	48318403	110820260	218	3606											
ZPBP	11055	broad.mit.edu	37	chr7	50129302	50129302	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttggtaatcgaaccaagtgtCcaactatcaaaaaaaaagat	19	9	6	7	1	1	1	1	0	0	1	3	2	2	1	2	1	2	1	2	1	9	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:50129302C>G	uc003tou.2	-	2	201	c.131G>C	c.(130-132)GGA>GCA	p.G44A	ZPBP_uc010kyw.2_Missense_Mutation_p.G44A	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	44					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					AACCAAGTGTCCAACTATCAA	0.318													16	22					0	0	0	0	G	50129302	G	G	50129302	3	3	16	1	0	0	0	0	1	0	0	0	18286	855	30	2	952	2	ZPBP	7	50129302	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1810899	50129302	109009361	219	3607											
GTF2I	2969	broad.mit.edu	37	chr7	74113421	74113421	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggactatttctgcttttgCtatggtaaaaacaatagatt	13	15	8	5	0	1	1	0	0	1	1	1	3	1	2	0	2	3	3	0	2	7	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:74113421C>G	uc003uau.2	+	4	739	c.369C>G	c.(367-369)TGC>TGG	p.C123W	GTF2I_uc003uat.2_Missense_Mutation_p.C123W|GTF2I_uc003uav.2_Missense_Mutation_p.C123W|GTF2I_uc003uaw.2_Missense_Mutation_p.C123W|GTF2I_uc003uay.2_Missense_Mutation_p.C123W|GTF2I_uc003uax.2_Missense_Mutation_p.C123W	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	123	GTF2I-like 1.				negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TCTGCTTTTGCTATGGTAAAA	0.294													7	23					0	0	0	0	G	74113421	G	G	74113421	3	3	16	1	0	0	0	0	1	0	0	0	6906	805	28	4	379	4	GTF2I	7	74113421	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	23984119	74113421	85025242	220	3608											
PHTF2	57157	broad.mit.edu	37	chr7	77569410	77569410	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atgcagtctctctcatactgGgtttaactccatttgttttc	7	18	6	10	0	2	0	1	0	2	0	6	0	3	0	1	1	3	3	1	1	2	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:77569410G>A	uc003ugs.3	+	13	1657	c.1531G>A	c.(1531-1533)GGT>AGT	p.G511S	PHTF2_uc003ugp.2_Missense_Mutation_p.G473S|PHTF2_uc003ugq.3_Missense_Mutation_p.G473S|PHTF2_uc010ldv.2_Missense_Mutation_p.G473S|PHTF2_uc003ugt.3_Missense_Mutation_p.G477S|PHTF2_uc003ugu.3_Missense_Mutation_p.G473S|PHTF2_uc010ldw.1_Missense_Mutation_p.G293S	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						TCTCATACTGGGTTTAACTCC	0.408													21	59					0	0	0	0	A	77569410	A	A	77569410	3	1	16	1	0	0	0	0	1	0	0	0	11918	1232	43	4	1529	4	PHTF2	7	77569410	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3455989	77569410	81569253	221	3609											
PCLO	27445	broad.mit.edu	37	chr7	82538271	82538271	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagaccatgtccattttcCaaacgagactccctgggttt	9	12	7	13	1	0	2	0	0	0	2	4	3	4	2	5	1	1	1	5	1	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:82538271C>A	uc003uhx.2	-	8	13648	c.13359G>T	c.(13357-13359)TTG>TTT	p.L4453F	PCLO_uc003uhv.2_Missense_Mutation_p.L4453F	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4384					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTCCATTTTCCAAACGAGACT	0.443													22	58					2.37509e-13	3.03879e-13	1	0	A	82538271	A	A	82538271	3	1	16	1	0	0	0	0	1	0	0	0	11637	593	21	4	2158	4	PCLO	7	82538271	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4968861	82538271	76600392	222	3610											
CDK14	5218	broad.mit.edu	37	chr7	90419960	90419960	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggacacctttcacagctatCagggaaggtaggcacttttc	10	10	11	10	0	2	0	2	0	0	0	3	2	2	2	1	4	1	3	1	4	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:90419960C>T	uc003uky.2	+	5	759	c.537C>T	c.(535-537)ATC>ATT	p.I179I	CDK14_uc003ukt.1_Silent_p.I133I|CDK14_uc003ukv.1_Silent_p.I133I|CDK14_uc003uku.1_Silent_p.I133I|CDK14_uc003ukx.1_RNA|CDK14_uc003ukz.1_Silent_p.I161I|CDK14_uc010les.1_Silent_p.I133I|CDK14_uc011khl.1_Silent_p.I50I	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	179	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						TCACAGCTATCAGGGAAGGTA	0.403													15	32					0	0	0	0	T	90419960	T	T	90419960	2	4	16	1	0	0	0	0	0	0	0	1	3145	816	29	2		2	CDK14	7	90419960	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	7881689	90419960	68718703	223	3611											
CASD1	64921	broad.mit.edu	37	chr7	94183816	94183816	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttagccttcatcctaataAgaaacatccctggatatgcc	12	13	5	11	0	1	1	1	0	0	1	3	2	3	2	4	1	3	0	4	1	5	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:94183816A>G	uc003uni.3	+	17	2283	c.2056A>G	c.(2056-2058)AGA>GGA	p.R686G	CASD1_uc003unj.3_Missense_Mutation_p.R686G	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	686	Helical; (Potential).					integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CATCCTAATAAGAAACATCCC	0.274													24	59					0	0	0	0	G	94183816	G	G	94183816	3	3	16	1	0	0	0	0	1	0	0	0	2676	64	3	5	2122	5	CASD1	7	94183816	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	3763856	94183816	64954847	224	3612											
PPP1R9A	55607	broad.mit.edu	37	chr7	94740690	94740690	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagctggaacttttcccagtGgagctagagaaaggttcgtg	11	10	13	7	1	0	1	0	0	0	1	2	4	1	3	1	3	3	3	1	3	4	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:94740690G>T	uc003unp.2	+	3	1797	c.1515G>T	c.(1513-1515)GTG>GTT	p.V505V	PPP1R9A_uc010lfj.2_Silent_p.V505V|PPP1R9A_uc011kif.1_Silent_p.V505V|PPP1R9A_uc003unq.2_Silent_p.V505V|PPP1R9A_uc011kig.1_Silent_p.V505V	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	505	PDZ.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TTTTCCCAGTGGAGCTAGAGA	0.373										HNSCC(28;0.073)			23	46					2.32416e-17	3.15632e-17	1	0	T	94740690	T	T	94740690	2	4	16	1	0	0	0	0	0	0	0	1	12438	1335	47	4		4	PPP1R9A	7	94740690	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	556874	94740690	64397973	225	3613											
PUS7	54517	broad.mit.edu	37	chr7	105111200	105111200	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcctcgaagcagctgcccttCcacacaccttttgacaggta	9	10	7	15	1	0	1	0	1	0	0	3	2	2	1	4	1	3	3	4	1	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:105111200C>A	uc003vcx.2	-	11	1552	c.1333G>T	c.(1333-1335)GAA>TAA	p.E445*	PUS7_uc010lji.2_Nonsense_Mutation_p.E451*|PUS7_uc003vcy.2_Nonsense_Mutation_p.E445*|PUS7_uc003vcz.1_Nonsense_Mutation_p.E445*	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	445	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						AGCTGCCCTTCCACACACCTT	0.453													56	89					2.17126e-26	3.18484e-26	1	0	A	105111200	A	A	105111200	4	1	16	1	0	0	0	0	0	1	0	0	12898	864	30	2	676	2	PUS7	7	105111200	Nonsense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	10370510	105111200	54027463	226	3614											
CFTR	1080	broad.mit.edu	37	chr7	117267811	117267811	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacatttccttctcaataaGtcctggccagagggtgagat	11	11	10	9	0	1	2	1	1	1	2	4	4	3	2	3	2	1	0	3	2	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:117267811G>T	uc003vjd.2	+	22	3836	c.3704G>T	c.(3703-3705)AGT>ATT	p.S1235I	CFTR_uc011knq.1_Missense_Mutation_p.S641I	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	1235	Cytoplasmic (Potential).|ABC transporter 2.		S -> R (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TTCTCAATAAGTCCTGGCCAG	0.438									Cystic_Fibrosis				11	43					0.00136819	0.00141682	1	0	T	117267811	T	T	117267811	3	4	16	1	0	0	0	0	1	0	0	0	3309	1029	36	4	3790	4	CFTR	7	117267811	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	12156611	117267811	41870852	227	3615											
CTTNBP2	83992	broad.mit.edu	37	chr7	117432538	117432538	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttggcacgaagctgttcccGctcagtgtcaaactcagaga	10	9	10	12	2	3	1	3	0	0	1	4	3	4	1	1	1	2	4	1	1	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:117432538G>T	uc003vjf.2	-	4	804	c.712C>A	c.(712-714)CGG>AGG	p.R238R		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	238	Potential.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		AGCTGTTCCCGCTCAGTGTCA	0.453													13	39					2.27111e-07	2.54953e-07	1	0	T	117432538	T	T	117432538	2	4	16	1	0	0	0	0	0	0	0	1	4062	1086	38	3		3	CTTNBP2	7	117432538	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	164727	117432538	41706125	228	3616											
KCND2	3751	broad.mit.edu	37	chr7	119915355	119915355	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaactgccctgtggagaGcggtatgctgtggccttctt	8	11	13	9	1	1	2	0	0	1	2	1	3	1	2	2	3	4	2	2	3	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:119915355G>T	uc003vjj.1	+	1	1634	c.669G>T	c.(667-669)GAG>GAT	p.E223D		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	223					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					CCTGTGGAGAGCGGTATGCTG	0.542													27	39					7.41945e-09	8.63134e-09	1	0	T	119915355	T	T	119915355	3	4	16	1	0	0	0	0	1	0	0	0	8058	962	34	4	671	4	KCND2	7	119915355	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2482817	119915355	39223308	229	3617											
EXOC4	60412	broad.mit.edu	37	chr7	133502223	133502223	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agattgaaggagtcactaaaAcatctgaccctttgaagatt	15	11	8	7	0	2	5	1	3	1	2	2	6	2	6	1	1	1	0	1	1	4	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:133502223A>G	uc003vrk.2	+	11	1695	c.1660A>G	c.(1660-1662)ACA>GCA	p.T554A	EXOC4_uc011kpo.1_Missense_Mutation_p.T453A|EXOC4_uc003vrl.2_Missense_Mutation_p.T164A|EXOC4_uc011kpp.1_Missense_Mutation_p.T86A	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	554					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AGTCACTAAAACATCTGACCC	0.443													18	23					0	0	0	0	G	133502223	G	G	133502223	3	3	16	1	0	0	0	0	1	0	0	0	5330	43	2	5	1711	5	EXOC4	7	133502223	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	13586868	133502223	25636440	230	3618											
DENND2A	27147	broad.mit.edu	37	chr7	140301270	140301270	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagaggaaggtgggggagAggagggcagaggcgggggag	11	1	25	4	1	0	3	0	0	0	3	0	7	0	6	0	9	0	1	0	9	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:140301270A>C	uc010lnj.2	-	1	1073	c.928T>G	c.(928-930)TCT>GCT	p.S310A	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.S310A|DENND2A_uc003vvw.2_Missense_Mutation_p.S310A|DENND2A_uc003vvx.2_Missense_Mutation_p.S310A	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	310								p.S310A(1)		ovary(3)|breast(1)	4	Melanoma(164;0.00956)					ggtgggggagaggagggcaga	0.403													14	37					0	0	0	0	C	140301270	C	C	140301270	3	2	16	1	0	0	0	0	1	0	0	0	4451	304	11	5	2173	5	DENND2A	7	140301270	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	6799047	140301270	18837393	231	3619											
MGAM	8972	broad.mit.edu	37	chr7	141727480	141727480	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagtcgttacgaatatggaaCcttagacaacatgagggaag	15	8	11	7	2	0	2	0	1	0	1	1	5	0	4	1	2	3	1	1	2	7	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:141727480C>T	uc003vwy.2	+	10	1220	c.1166C>T	c.(1165-1167)ACC>ATC	p.T389I		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	389	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GAATATGGAACCTTAGACAAC	0.463													12	28					0	0	0	0	T	141727480	T	T	141727480	3	4	16	1	0	0	0	0	1	0	0	0	9594	507	18	4	1200	4	MGAM	7	141727480	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1426210	141727480	17411183	232	3620											
OR9A2	135924	broad.mit.edu	37	chr7	142723861	142723861	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaagggttacacacagccAcataacggtccacagccatc	14	6	7	14	1	1	0	1	0	0	0	3	0	2	0	3	2	4	1	3	2	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:142723861A>T	uc003wcc.1	-	1	359	c.359T>A	c.(358-360)GTG>GAG	p.V120E		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					ACACACAGCCACATAACGGTC	0.438													28	57					0	0	0	0	T	142723861	T	T	142723861	3	4	16	1	0	0	0	0	1	0	0	0	11302	159	6	5	577	5	OR9A2	7	142723861	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	996381	142723861	16414802	233	3621											
TAS2R60	338398	broad.mit.edu	37	chr7	143141256	143141256	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcaggattccgagagccCagtgtgcaggcacacataaa	13	6	10	12	1	1	1	1	0	0	1	2	3	2	2	3	2	2	2	3	2	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:143141256C>A	uc011ktg.1	+	1	711	c.711C>A	c.(709-711)CCC>CCA	p.P237P	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	237	Helical; Name=6; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					TCCGAGAGCCCAGTGTGCAGG	0.483													38	69					2.09667e-21	2.94729e-21	1	0	A	143141256	A	A	143141256	2	1	16	1	0	0	0	0	0	0	0	1	15651	581	21	4		4	TAS2R60	7	143141256	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	417395	143141256	15997407	234	3622											
CNTNAP2	26047	broad.mit.edu	37	chr7	146741075	146741075	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gattattgcccgctatgtgcGcatagtgcctctggattgga	7	13	12	9	2	1	0	0	0	1	0	1	3	1	2	2	2	3	2	2	2	3	5	rs138738227	by1000genomes	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:146741075G>C	uc003weu.1	+	4	995	c.479G>C	c.(478-480)CGC>CCC	p.R160P		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	160	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CGCTATGTGCGCATAGTGCCT	0.433										HNSCC(39;0.1)			27	79					0	0	0	0	C	146741075	C	C	146741075	3	2	16	1	0	0	0	0	1	0	0	0	3662	1087	38	3	493	3	CNTNAP2	7	146741075	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3599819	146741075	12397588	235	3623											
KCNH2	3757	broad.mit.edu	37	chr7	150644574	150644574	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgactgtccccccagaagctGaaaatgttggacactcctga	11	8	9	13	1	0	3	0	2	0	1	2	5	2	4	4	1	1	2	4	1	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:150644574G>A	uc003wic.2	-	13	3007	c.2994C>T	c.(2992-2994)TTC>TTT	p.F998F	KCNH2_uc003wib.2_Silent_p.F658F|KCNH2_uc011kux.1_Silent_p.F902F	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	998	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CCCAGAAGCTGAAAATGTTGG	0.692													5	11					0	0	0	0	A	150644574	A	A	150644574	2	1	16	1	0	0	0	0	0	0	0	1	8071	1281	45	2		2	KCNH2	7	150644574	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3903499	150644574	8494089	236	3624											
DPP6	1804	broad.mit.edu	37	chr7	154684051	154684051	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttccttgcagatttaccCggacgaaagccattacttta	10	12	7	12	2	0	1	0	0	0	1	1	3	1	2	4	1	4	1	4	1	4	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:154684051C>G	uc003wlk.2	+	26	2588	c.2459C>G	c.(2458-2460)CCG>CGG	p.P820R	DPP6_uc003wli.2_Missense_Mutation_p.P756R|DPP6_uc003wlm.2_Missense_Mutation_p.P758R|DPP6_uc011kvq.1_Missense_Mutation_p.P713R	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	820	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CAGATTTACCCGGACGAAAGC	0.517													30	48					0	0	0	0	G	154684051	G	G	154684051	3	3	16	1	0	0	0	0	1	0	0	0	4752	652	23	3	2677	3	DPP6	7	154684051	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4039477	154684051	4454612	237	3625											
EN2	2020	broad.mit.edu	37	chr7	155255140	155255140	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgcacggcctttaccgccGagcagctgcagaggctcaag	8	5	13	15	5	1	1	1	0	0	1	1	2	1	1	3	2	4	5	3	2	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:155255140G>T	uc003wmb.2	+	2	1009	c.760G>T	c.(760-762)GAG>TAG	p.E254*		NM_001427	NP_001418	P19622	HME2_HUMAN	engrailed homeobox 2	254	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTTTACCGCCGAGCAGCTGCA	0.607													26	85					5.45024e-15	7.18849e-15	1	0	T	155255140	T	T	155255140	4	4	16	1	0	0	0	0	0	1	0	0	5134	1059	37	3	766	3	EN2	7	155255140	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	571089	155255140	3883523	238	3626											
WDR60	55112	broad.mit.edu	37	chr7	158718989	158718989	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcacccttttctactcaagAaggtacgtgattcttcactt	9	16	5	11	1	5	2	3	1	2	1	5	2	5	2	1	1	2	1	1	1	4	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr7:158718989A>T	uc003woe.3	+	18	2527	c.2369A>T	c.(2368-2370)GAA>GTA	p.E790V	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_Missense_Mutation_p.E422V	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	790	WD 2.									ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TCTACTCAAGAAGGTACGTGA	0.388													6	12					0	0	0	0	T	158718989	T	T	158718989	3	4	16	1	0	0	0	0	1	0	0	0	17379	246	9	5	2439	5	WDR60	7	158718989	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	3463849	158718989	419674	239	3627											
CSMD1	64478	broad.mit.edu	37	chr8	2820892	2820894	+	In_Frame_Del	DEL	CGG	-	-																															tccactgttccattctgcacCggcggcggctgaggacacag																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:2820892_2820894delCGG	uc011kwk.1	-	60	9697_9699	c.9307_9309delCCG	c.(9307-9309)CCGdel	p.P3103del	CSMD1_uc011kwj.1_In_Frame_Del_p.P2432del|CSMD1_uc010lrg.2_In_Frame_Del_p.P994del	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3103	Sushi 25.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CATTCTGCACCGGCGGCGGCTGA	0.537													---	---	---								-	2820894	-	-	2820892	7	5	16	1	0	1	0	1	0	0	0	0	3961	639	23	0	1432	0	CSMD1	8	2820892	In_Frame_Del	DEL	CGG	TCGA-BA-6869-01A-11D-1870-08		2820892	143543130	240	3628											
CSMD1	64478	broad.mit.edu	37	chr8	2820916	2820916	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcggctgaggacacagcacGgctatttccaaagaacaaac	14	5	11	11	2	0	2	0	1	0	1	1	3	1	3	1	4	3	3	1	4	4	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:2820916G>T	uc011kwk.1	-	60	9675	c.9285C>A	c.(9283-9285)GCC>GCA	p.A3095A	CSMD1_uc011kwj.1_Silent_p.A2424A|CSMD1_uc010lrg.2_Silent_p.A986A	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3095	Extracellular (Potential).|Sushi 24.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GACACAGCACGGCTATTTCCA	0.498													51	101					6.56871e-35	9.95401e-35	1	0	T	2820916	T	T	2820916	2	4	16	1	0	0	0	0	0	0	0	1	3961	1130	39	3		3	CSMD1	8	2820916	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	24	2820916	143543106	241	3629											
SOX7	83595	broad.mit.edu	37	chr8	10583781	10583781	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctgctccggctccagcaCgtccaggggagacatttcag	7	8	13	13	2	2	1	1	0	1	1	5	2	5	1	3	4	2	3	3	4	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:10583781C>A	uc003wtf.2	-	2	713	c.634G>T	c.(634-636)GTG>TTG	p.V212L	SOX7_uc011kwz.1_Missense_Mutation_p.V264L	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	212					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GGCTCCAGCACGTCCAGGGGA	0.701													17	25					7.07596e-05	7.47231e-05	1	0	A	10583781	A	A	10583781	3	1	16	1	0	0	0	0	1	0	0	0	15020	536	19	3	536	3	SOX7	8	10583781	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	7762865	10583781	135780241	242	3630											
DLC1	10395	broad.mit.edu	37	chr8	12957730	12957730	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttgagctgcttcagcttctCctcatccatcccctcttgca	5	14	6	16	0	4	1	2	1	2	0	7	1	6	1	4	0	4	5	4	0	0	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:12957730C>T	uc003wwm.2	-	9	2560	c.2116G>A	c.(2116-2118)GAG>AAG	p.E706K	DLC1_uc003wwk.1_Missense_Mutation_p.E269K|DLC1_uc003wwl.1_Missense_Mutation_p.E303K|DLC1_uc011kxx.1_Missense_Mutation_p.E195K	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	706					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TTCAGCTTCTCCTCATCCATC	0.567													21	33					0	0	0	0	T	12957730	T	T	12957730	3	4	16	1	0	0	0	0	1	0	0	0	4572	864	30	2	2510	2	DLC1	8	12957730	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2373949	12957730	133406292	243	3631											
INTS10	55174	broad.mit.edu	37	chr8	19681415	19681415	+	Frame_Shift_Del	DEL	T	-	-																															acatctgatttaatgtcaccTagcaaacgtagctctcagaa																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:19681415delT	uc003wzj.2	+	7	827	c.696delT	c.(694-696)CCTfs	p.P232fs		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	232					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		TAATGTCACCTAGCAAACGTA	0.403													---	---	---								-	19681415	-	-	19681415	7	5	16	1	0	1	0	1	0	0	0	0	7815	1509	53	0	722	0	INTS10	8	19681415	Frame_Shift_Del	DEL	T	TCGA-BA-6869-01A-11D-1870-08	6723685	19681415	126682607	244	3632											
UNC5D	137970	broad.mit.edu	37	chr8	35406851	35406851	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcccgaatccatcccatcaGctcctgggacactgcctcat	8	10	6	17	1	2	0	2	0	0	0	6	2	6	1	5	1	2	1	5	1	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:35406851G>C	uc003xjr.1	+	2	473	c.145G>C	c.(145-147)GCT>CCT	p.A49P	UNC5D_uc003xjs.1_Missense_Mutation_p.A44P	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	49	Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CATCCCATCAGCTCCTGGGAC	0.483													13	40					0	0	0	0	C	35406851	C	C	35406851	3	2	16	1	0	0	0	0	1	0	0	0	17063	971	34	4	151	4	UNC5D	8	35406851	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	15725436	35406851	110957171	245	3633											
KCNU1	157855	broad.mit.edu	37	chr8	36776389	36776389	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taatgagaaatcaaactgccGaaaagtccctatccttactg	15	10	6	10	1	1	1	1	1	0	1	3	3	3	1	3	0	3	0	3	0	7	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:36776389G>A	uc010lvw.2	+	23	2657	c.2570G>A	c.(2569-2571)CGA>CAA	p.R857Q	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	857	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TCAAACTGCCGAAAAGTCCCT	0.358													17	84					0	0	0	0	A	36776389	A	A	36776389	3	1	16	1	0	0	0	0	1	0	0	0	8132	1058	37	1	2660	1	KCNU1	8	36776389	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1369538	36776389	109587633	246	3634											
DDHD2	23259	broad.mit.edu	37	chr8	38095108	38095108	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggaaaaagaaactggaatCtcccaacagagaaattatta	20	8	7	6	0	1	2	0	0	1	2	2	5	1	4	1	2	2	0	1	2	8	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:38095108C>G	uc003xlb.2	+	4	841	c.464C>G	c.(463-465)TCT>TGT	p.S155C	DDHD2_uc003xla.2_Missense_Mutation_p.S155C|DDHD2_uc003xlc.2_Missense_Mutation_p.S155C|DDHD2_uc011lbl.1_Missense_Mutation_p.I7M	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	155					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			AAACTGGAATCTCCCAACAGA	0.328													7	14					0	0	0	0	G	38095108	G	G	38095108	3	3	16	1	0	0	0	0	1	0	0	0	4344	913	32	2	474	2	DDHD2	8	38095108	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1318719	38095108	108268914	247	3635											
PXDNL	137902	broad.mit.edu	37	chr8	52287228	52287228	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggtcccactcttgtaccAggaatcaggtcttcaaccat	9	12	8	12	0	4	0	2	0	2	0	5	1	5	1	3	3	2	2	3	3	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:52287228A>G	uc003xqu.3	-	18	3722	c.3621T>C	c.(3619-3621)CCT>CCC	p.P1207P	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1207					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTCTTGTACCAGGAATCAGGT	0.483													12	39					0	0	0	0	G	52287228	G	G	52287228	2	3	16	1	0	0	0	0	0	0	0	1	12913	175	7	5		5	PXDNL	8	52287228	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	14192120	52287228	94076794	248	3636											
RP1	6101	broad.mit.edu	37	chr8	55533949	55533950	+	Frame_Shift_Ins	INS	-	G	G																															cgcactcaccgccccaccccINSgtagccgtcgctgctcccgg																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:55533949_55533950insG	uc003xsd.1	+	2	571_572	c.423_424insG	c.(421-426)CCCGTAfs	p.P141fs	RP1_uc011ldy.1_Frame_Shift_Ins_p.P141fs	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	141_142					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CGCCCCACCCCGTAGCCGTCGC	0.698													---	---	---								G	55533950	G	G	55533949	7	5	16	1	0	1	1	0	0	0	0	0	13597	639	23	0	425	0	RP1	8	55533949	Frame_Shift_Ins	INS	-	TCGA-BA-6869-01A-11D-1870-08	3246721	55533949	90830073	249	3637											
EYA1	2138	broad.mit.edu	37	chr8	72182001	72182001	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atatctgttggcgtaggaccCagtaagcaaggagtggaaaa	14	8	13	6	1	1	0	0	0	1	0	1	3	1	3	1	4	1	4	1	4	6	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:72182001C>A	uc003xys.3	-	10	1311	c.1024G>T	c.(1024-1026)GGG>TGG	p.G342W	EYA1_uc003xyr.3_Missense_Mutation_p.G337W|EYA1_uc003xyt.3_Missense_Mutation_p.G309W|EYA1_uc010lzf.2_Missense_Mutation_p.G269W|EYA1_uc003xyu.2_Missense_Mutation_p.G342W|EYA1_uc011lfe.1_Missense_Mutation_p.G336W|EYA1_uc003xyv.2_Missense_Mutation_p.G220W	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	342					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			GCGTAGGACCCAGTAAGCAAG	0.398													33	91					6.29468e-14	8.1513e-14	1	0	A	72182001	A	A	72182001	3	1	16	1	0	0	0	0	1	0	0	0	5353	594	21	4	786	4	EYA1	8	72182001	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	16648052	72182001	74182021	250	3638											
EYA1	2138	broad.mit.edu	37	chr8	72229917	72229917	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtcttgatgcctgcccaCaatgcacctaaatcagttag	11	11	7	12	0	3	1	2	1	1	0	3	1	3	1	3	0	3	2	3	0	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:72229917C>G	uc003xys.3	-	6	713	c.426G>C	c.(424-426)TTG>TTC	p.L142F	EYA1_uc003xyr.3_Intron|EYA1_uc003xyt.3_Missense_Mutation_p.L109F|EYA1_uc010lzf.2_Missense_Mutation_p.L69F|EYA1_uc003xyu.2_Missense_Mutation_p.L142F|EYA1_uc011lfe.1_Intron|EYA1_uc003xyv.2_Intron	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	142					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TGCCTGCCCACAATGCACCTA	0.423													37	96					0	0	0	0	G	72229917	G	G	72229917	3	3	16	1	0	0	0	0	1	0	0	0	5353	477	17	4	1400	4	EYA1	8	72229917	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	47916	72229917	74134105	251	3639											
MSC	9242	broad.mit.edu	37	chr8	72756070	72756070	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgcatccgggcacgctcaCgggcgttggccgcgttccgc	3	6	15	17	9	1	0	1	0	0	0	3	0	3	0	3	3	0	5	3	3	0	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:72756070C>T	uc003xyx.1	-	1	662	c.344G>A	c.(343-345)CGT>CAT	p.R115H	uc011lff.1_Intron|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	115	Basic motif.				transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			GGCACGCTCACGGGCGTTGGC	0.692											OREG0018826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	17					0	0	0	0	T	72756070	T	T	72756070	3	4	16	1	0	0	0	0	1	0	0	0	9921	536	19	1	284	1	MSC	8	72756070	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	526153	72756070	73607952	252	3640											
TRPA1	8989	broad.mit.edu	37	chr8	72951141	72951141	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatcactagtttcattgaTgatgccagttgagttgaaag	12	14	10	5	0	2	5	2	5	0	0	2	5	2	5	1	0	1	3	1	0	2	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:72951141T>A	uc003xza.2	-	19	2429	c.2254A>T	c.(2254-2256)ATC>TTC	p.I752F	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	752	Extracellular (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GTTTCATTGATGATGCCAGTT	0.299													26	46					0	0	0	0	A	72951141	A	A	72951141	3	1	16	1	0	0	0	0	1	0	0	0	16644	1464	51	5	1141	5	TRPA1	8	72951141	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	195071	72951141	73412881	253	3641											
TPD52	7163	broad.mit.edu	37	chr8	80976829	80976829	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtctgttctcagcagacCtggttggggatttaaaccat	8	13	12	8	0	2	1	1	0	2	1	3	2	2	2	2	4	2	3	2	4	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:80976829C>A	uc003ybr.1	-	2	462	c.140_splice	c.e2-1	p.G47_splice	TPD52_uc010lzr.2_Splice_Site|TPD52_uc010lzs.1_Splice_Site|TPD52_uc003ybs.1_Splice_Site_p.G7_splice|TPD52_uc003ybt.1_Splice_Site_p.G7_splice|TPD52_uc003ybq.1_Splice_Site|TPD52_uc003ybu.1_Splice_Site	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1						anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			CTCAGCAGACCTGGTTGGGGA	0.463													40	81					8.69298e-16	1.16573e-15	1	0	A	80976829	A	A	80976829	5	1	16	1	0	0	0	0	0	0	1	0	16464	695	24	4	632	4	TPD52	8	80976829	Splice_Site	SNP	C	TCGA-BA-6869-01A-11D-1870-08	8025688	80976829	65387193	254	3642											
VPS13B	157680	broad.mit.edu	37	chr8	100523713	100523713	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcagaatttttattccaaaaAcagaagaaatgcagccaact	18	10	5	8	0	1	3	1	0	0	3	2	3	2	3	2	0	4	1	2	0	7	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:100523713A>T	uc003yiv.2	+	29	4792	c.4681A>T	c.(4681-4683)ACA>TCA	p.T1561S	VPS13B_uc003yiw.2_Missense_Mutation_p.T1536S|VPS13B_uc003yix.1_Missense_Mutation_p.T1031S	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1561					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TATTCCAAAAACAGAAGAAAT	0.343													13	25					0	0	0	0	T	100523713	T	T	100523713	3	4	16	1	0	0	0	0	1	0	0	0	17258	43	2	5	4985	5	VPS13B	8	100523713	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	19546884	100523713	45840309	255	3643											
RIMS2	9699	broad.mit.edu	37	chr8	104898351	104898351	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aagaaaggcggtaaaatgcgCcagatttcgttgagcagttc	13	9	12	7	3	0	3	0	1	0	2	2	3	0	3	1	2	2	4	1	2	4	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:104898351C>T	uc003yls.2	+	2	1099	c.858C>T	c.(856-858)CGC>CGT	p.R286R	RIMS2_uc003ylp.2_Silent_p.R508R|RIMS2_uc003ylw.2_Silent_p.R316R|RIMS2_uc003ylq.2_Silent_p.R316R|RIMS2_uc003ylr.2_Silent_p.R316R	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	539					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTAAAATGCGCCAGATTTCGT	0.423										HNSCC(12;0.0054)			13	24					0	0	0	0	T	104898351	T	T	104898351	2	4	16	1	0	0	0	0	0	0	0	1	13433	726	26	4		4	RIMS2	8	104898351	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4374638	104898351	41465671	256	3644											
RIMS2	9699	broad.mit.edu	37	chr8	104922385	104922385	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acatggattacaactggttgGatcatacgtcttggcatagc	11	12	10	8	1	2	0	1	0	1	0	2	2	2	2	0	4	4	2	0	4	4	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:104922385G>C	uc003yls.2	+	3	1223	c.982G>C	c.(982-984)GAT>CAT	p.D328H	RIMS2_uc003ylp.2_Missense_Mutation_p.D550H|RIMS2_uc003ylw.2_Missense_Mutation_p.D358H|RIMS2_uc003ylq.2_Missense_Mutation_p.D358H|RIMS2_uc003ylr.2_Intron|RIMS2_uc003ylt.2_5'Flank	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CAACTGGTTGGATCATACGTC	0.393										HNSCC(12;0.0054)			32	91					0	0	0	0	C	104922385	C	C	104922385	3	2	16	1	0	0	0	0	1	0	0	0	13433	1174	41	2	1792	2	RIMS2	8	104922385	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	24034	104922385	41441637	257	3645											
PKHD1L1	93035	broad.mit.edu	37	chr8	110455181	110455181	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcattttatggcaggttcatTttcttaccaatttacttctc	8	20	4	9	0	4	0	2	0	2	0	5	0	4	0	1	2	2	2	1	2	4	9			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:110455181T>A	uc003yne.2	+	36	4504	c.4400T>A	c.(4399-4401)TTT>TAT	p.F1467Y		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1467	Extracellular (Potential).|IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCAGGTTCATTTTCTTACCAA	0.318										HNSCC(38;0.096)			21	36					0	0	0	0	A	110455181	A	A	110455181	3	1	16	1	0	0	0	0	1	0	0	0	12027	1841	64	5	4542	5	PKHD1L1	8	110455181	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	5532796	110455181	35908841	258	3646											
CSMD3	114788	broad.mit.edu	37	chr8	113267587	113267587	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagctgaatgaaacctctGactggtatataaagcttttg	12	13	9	7	0	1	3	0	3	1	0	1	3	1	3	1	1	4	4	1	1	6	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:113267587G>T	uc003ynu.2	-	62	10091	c.9932C>A	c.(9931-9933)TCA>TAA	p.S3311*	CSMD3_uc003yns.2_Nonsense_Mutation_p.S2513*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.S3271*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.S3142*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3311	Extracellular (Potential).|Sushi 26.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGAAACCTCTGACTGGTATAT	0.418										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	50					1.42536e-11	1.77065e-11	1	0	T	113267587	T	T	113267587	4	4	16	1	0	0	0	0	0	1	0	0	3963	1294	45	2	1231	2	CSMD3	8	113267587	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2812406	113267587	33096435	259	3647											
CSMD3	114788	broad.mit.edu	37	chr8	113668416	113668416	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgaaaccattattggaacGactgttgtctgttgtaaata	12	15	8	6	1	1	1	0	1	1	0	1	3	1	2	1	1	2	3	1	1	6	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:113668416G>T	uc003ynu.2	-	18	3130	c.2971C>A	c.(2971-2973)CGT>AGT	p.R991S	CSMD3_uc003yns.2_Missense_Mutation_p.R263S|CSMD3_uc003ynt.2_Missense_Mutation_p.R951S|CSMD3_uc011lhx.1_Missense_Mutation_p.R887S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	991	Extracellular (Potential).|CUB 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTATTGGAACGACTGTTGTCT	0.328										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	70					4.7796e-09	5.58056e-09	1	0	T	113668416	T	T	113668416	3	4	16	1	0	0	0	0	1	0	0	0	3963	1058	37	3	8368	3	CSMD3	8	113668416	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	400829	113668416	32695606	260	3648											
C8orf85	441376	broad.mit.edu	37	chr8	117954796	117954796	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttatttttttctaacttttaGgtggaaatgcatttccaaaa	12	19	5	5	0	1	0	0	0	1	0	2	1	2	1	1	2	2	1	1	2	6	8	rs77850379		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:117954796G>A	uc003yof.2	+	2	344	c.325_splice	c.e2-1	p.V109_splice		NM_001025357	NP_001020528	Q4LEZ3	AARD_HUMAN	alanine and arginine-rich domain-containing												0						CTAACTTTTAGGTGGAAATGC	0.343													8	16					0	0	0	0	A	117954796	A	A	117954796	5	1	16	1	0	0	0	0	0	0	1	0	2453	1014	35	4	330	4	C8orf85	8	117954796	Splice_Site	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4286380	117954796	28409226	261	3649											
FER1L6	654463	broad.mit.edu	37	chr8	124978246	124978246	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattaaactttcttttaataGatcaaaactgttgactaaga	16	16	4	5	0	2	3	1	1	1	2	2	3	2	3	0	0	2	1	0	0	8	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:124978246G>A	uc003yqw.2	+	4	404	c.198_splice	c.e4-1	p.R66_splice		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6							integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCTTTTAATAGATCAAAACTG	0.358													6	21					0	0	0	0	A	124978246	A	A	124978246	5	1	16	1	0	0	0	0	0	0	1	0	5847	956	33	2	207	2	FER1L6	8	124978246	Splice_Site	SNP	G	TCGA-BA-6869-01A-11D-1870-08	7023450	124978246	21385776	262	3650											
KCNQ3	3786	broad.mit.edu	37	chr8	133175730	133175730	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacctggatgctgcctccAgctgttctttcctagaaaga	8	13	8	12	0	1	2	0	0	1	2	3	3	3	3	4	1	4	3	4	1	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:133175730A>T	uc003ytj.2	-	9	1472	c.1247T>A	c.(1246-1248)CTG>CAG	p.L416Q	KCNQ3_uc010mdt.2_Missense_Mutation_p.L416Q	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	416					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TGCTGCCTCCAGCTGTTCTTT	0.443													22	48					0	0	0	0	T	133175730	T	T	133175730	3	4	16	1	0	0	0	0	1	0	0	0	8123	188	7	5	1399	5	KCNQ3	8	133175730	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	8197484	133175730	13188292	263	3651											
FAM135B	51059	broad.mit.edu	37	chr8	139263091	139263091	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgaacttcatacctgatcaAtggctgctgcagagccacca	11	9	8	13	0	2	3	2	2	0	1	2	3	2	3	3	1	5	3	3	1	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:139263091A>G	uc003yuy.2	-	6	706	c.535T>C	c.(535-537)TTG>CTG	p.L179L	FAM135B_uc003yux.2_Silent_p.L80L|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	179										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TACCTGATCAATGGCTGCTGC	0.562										HNSCC(54;0.14)			30	50					0	0	0	0	G	139263091	G	G	139263091	2	3	16	1	0	0	0	0	0	0	0	1	5477	98	4	5		5	FAM135B	8	139263091	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	6087361	139263091	7100931	264	3652											
COL22A1	169044	broad.mit.edu	37	chr8	139833498	139833498	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtcaatgtgcagggagaCgttctgggcctggatgctca	9	9	14	9	1	3	1	2	0	1	1	3	3	3	2	1	3	2	3	1	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr8:139833498C>A	uc003yvd.2	-	7	1573	c.1126G>T	c.(1126-1128)GTC>TTC	p.V376F		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	376	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TGCAGGGAGACGTTCTGGGCC	0.562										HNSCC(7;0.00092)			21	45					4.96729e-08	5.65548e-08	1	0	A	139833498	A	A	139833498	3	1	16	1	0	0	0	0	1	0	0	0	3696	536	19	3	3990	3	COL22A1	8	139833498	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	570407	139833498	6530524	265	3653											
KIAA1539	80256	broad.mit.edu	37	chr9	35107838	35107838	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaagcatttgatggggggCaggggggactccaggccccc	8	5	18	10	0	0	1	0	1	0	0	1	3	1	3	3	8	1	2	3	8	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:35107838C>T	uc003zwl.2	-	3	759	c.434G>A	c.(433-435)TGC>TAC	p.C145Y	KIAA1539_uc003zwm.2_Missense_Mutation_p.C145Y|KIAA1539_uc003zwn.2_Intron|KIAA1539_uc003zwo.2_Missense_Mutation_p.C145Y|KIAA1539_uc003zwp.1_Missense_Mutation_p.C145Y|KIAA1539_uc010mkk.1_Intron	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	145						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGATGGGGGGCAGGGGGGACT	0.627													31	57					0	0	0	0	T	35107838	T	T	35107838	3	4	16	1	0	0	0	0	1	0	0	0	8281	710	25	4	1210	4	KIAA1539	9	35107838	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08		35107838	106105593	266	3654											
RUSC2	9853	broad.mit.edu	37	chr9	35556330	35556330	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagtgaagccgttaccactGacctgccctgacttccagga	9	8	10	14	1	0	3	0	3	0	0	1	4	1	4	5	1	3	2	5	1	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:35556330G>A	uc003zww.2	+	5	3123	c.2868G>A	c.(2866-2868)CTG>CTA	p.L956L	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Silent_p.L956L	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	956						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			CGTTACCACTGACCTGCCCTG	0.542													27	48					0	0	0	0	A	35556330	A	A	35556330	2	1	16	1	0	0	0	0	0	0	0	1	13816	1277	45	2		2	RUSC2	9	35556330	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	448492	35556330	105657101	267	3655											
FAM75A6	389730	broad.mit.edu	37	chr9	43625328	43625328	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcctcaatccttcaagcCtttcttcatgtttttctaag	8	17	5	11	0	5	0	3	0	2	0	7	1	7	0	3	0	1	1	3	0	3	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:43625328C>A	uc011lrb.1	-	4	3388	c.3359G>T	c.(3358-3360)AGG>ATG	p.R1120M		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1120						integral to membrane					0						TCCTTCAAGCCTTTCTTCATG	0.473													50	106					2.92363e-43	4.47267e-43	1	0	A	43625328	A	A	43625328	3	1	16	1	0	0	0	0	1	0	0	0	5654	681	24	4	676	4	FAM75A6	9	43625328	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	8068998	43625328	97588103	268	3656											
C9orf79	286234	broad.mit.edu	37	chr9	90502039	90502039	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacctttaccccctgggcCtcctgggtatctcgggttga	4	12	10	15	1	1	1	0	1	1	0	4	1	3	1	6	3	1	2	6	3	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:90502039C>T	uc004app.3	+	4	2672	c.2637C>T	c.(2635-2637)GCC>GCT	p.A879A	C9orf79_uc004apo.1_Silent_p.A691A	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	879						integral to membrane				ovary(3)	3						CCCCCTGGGCCTCCTGGGTAT	0.557													15	21					0	0	0	0	T	90502039	T	T	90502039	2	4	16	1	0	0	0	0	0	0	0	1	2509	668	24	4		4	C9orf79	9	90502039	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	46876711	90502039	50711392	269	3657											
FAM22G	441457	broad.mit.edu	37	chr9	99694506	99694506	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcccccatcgtgtccccaggGaacgctgggccatggccaca	7	5	12	17	2	0	0	0	0	0	0	2	1	1	1	6	3	1	1	6	3	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:99694506G>A	uc004awq.1	+	2	1234	c.519G>A	c.(517-519)GGG>GGA	p.G173G		NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	173										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)				TGTCCCCAGGGAACGCTGGGC	0.682													26	126					0	0	0	0	A	99694506	A	A	99694506	2	1	16	1	0	0	0	0	0	0	0	1	5574	1161	41	2		2	FAM22G	9	99694506	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	9192467	99694506	41518925	270	3658											
COL15A1	1306	broad.mit.edu	37	chr9	101778282	101778282	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctggtgatgaagaagacttgGcagcagccacaacagaggag	14	5	14	8	0	0	5	0	2	0	3	0	6	0	6	1	3	3	2	1	3	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:101778282G>T	uc004azb.1	+	11	1734	c.1528G>T	c.(1528-1530)GCA>TCA	p.A510S		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	510	Nonhelical region 1 (NC1).|4.|4 X tandem repeats.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				AGAAGACTTGGCAGCAGCCAC	0.597													9	21					4.68919e-08	5.36745e-08	1	0	T	101778282	T	T	101778282	3	4	16	1	0	0	0	0	1	0	0	0	3687	1203	42	4	1570	4	COL15A1	9	101778282	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2083776	101778282	39435149	271	3659											
TMEFF1	8577	broad.mit.edu	37	chr9	103204596	103204596	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctacttcctgcagagccccCcggaggaggagcccgaatac	9	6	11	15	2	1	1	0	0	1	1	2	5	2	4	5	3	5	1	5	3	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:103204596C>A	uc004bay.1	+	1	409	c.376C>A	c.(376-378)CCG>ACG	p.P126T	C9orf30_uc004baw.2_Missense_Mutation_p.P126T|C9orf30_uc004bax.2_RNA	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two	Error:Variant_position_missing_in_Q8IYR6_after_alignment					multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)				GCAGAGCCCCCCGGAGGAGGA	0.587													15	36					5.01169e-05	5.3187e-05	1	0	A	103204596	A	A	103204596	3	1	16	1	0	0	0	0	1	0	0	0	16079	623	22	4		4	TMEFF1	9	103204596	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1426314	103204596	38008835	272	3660											
ZNF462	58499	broad.mit.edu	37	chr9	109691071	109691071	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagcccgagatgaccactgaAgtgagcccttcccaagtctc	10	7	10	14	1	1	4	0	3	1	1	3	6	2	4	4	0	2	0	4	0	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:109691071A>G	uc004bcz.2	+	3	5167	c.4878A>G	c.(4876-4878)GAA>GAG	p.E1626E	ZNF462_uc010mto.2_Silent_p.E1474E|ZNF462_uc004bda.2_Silent_p.E1474E	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1626					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						TGACCACTGAAGTGAGCCCTT	0.557													23	62					0	0	0	0	G	109691071	G	G	109691071	2	3	16	1	0	0	0	0	0	0	0	1	17993	69	3	5		5	ZNF462	9	109691071	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	6486475	109691071	31522360	273	3661											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112898559	112898559	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagaatgtaaaagtgttccTggaatcacctctaccccaca	13	9	7	12	0	2	1	1	0	1	1	3	2	3	2	4	1	1	3	4	1	5	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:112898559T>G	uc004bei.2	+	9	1623	c.1431T>G	c.(1429-1431)CCT>CCG	p.P477P	PALM2-AKAP2_uc004bek.3_Silent_p.P245P|PALM2-AKAP2_uc004bej.3_Silent_p.P245P|PALM2-AKAP2_uc004bel.1_Silent_p.P55P|AKAP2_uc011lwi.1_Silent_p.P103P|AKAP2_uc004bem.2_Silent_p.P103P|PALM2-AKAP2_uc010mtw.1_Silent_p.P63P|AKAP2_uc011lwj.1_Silent_p.P14P|PALM2-AKAP2_uc004ben.2_Silent_p.P14P	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	14							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AAAGTGTTCCTGGAATCACCT	0.502													31	88					0	0	0	0	G	112898559	G	G	112898559	2	3	16	1	0	0	0	0	0	0	0	1	11464	1567	55	5		5	PALM2-AKAP2	9	112898559	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	3207488	112898559	28314872	274	3662											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112899252	112899252	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaaaatggtggaatcccccGcaggaaaaaaccatcgagga	16	4	11	10	2	0	0	0	0	0	0	2	4	1	3	3	4	1	2	3	4	6	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:112899252G>T	uc004bei.2	+	9	2316	c.2124G>T	c.(2122-2124)CCG>CCT	p.P708P	PALM2-AKAP2_uc004bek.3_Silent_p.P476P|PALM2-AKAP2_uc004bej.3_Silent_p.P476P|PALM2-AKAP2_uc004bel.1_Silent_p.P286P|AKAP2_uc011lwi.1_Silent_p.P334P|AKAP2_uc004bem.2_Silent_p.P334P|PALM2-AKAP2_uc010mtw.1_Silent_p.P294P|AKAP2_uc011lwj.1_Silent_p.P245P|PALM2-AKAP2_uc004ben.2_Silent_p.P245P	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	245	Potential.						enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						GGAATCCCCCGCAGGAAAAAA	0.498													18	42					5.3912e-06	5.85722e-06	1	0	T	112899252	T	T	112899252	2	4	16	1	0	0	0	0	0	0	0	1	11464	1074	38	3		3	PALM2-AKAP2	9	112899252	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	693	112899252	28314179	275	3663											
ASTN2	23245	broad.mit.edu	37	chr9	119202971	119202971	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagtggtgctggactcggaaCagcatcgaggctgagacctc	9	8	14	10	2	0	1	0	1	0	1	3	5	0	3	1	4	3	3	1	4	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:119202971C>A	uc004bjs.1	-	22	3800	c.3699G>T	c.(3697-3699)CTG>CTT	p.L1233L	ASTN2_uc004bjr.1_Silent_p.L1229L|ASTN2_uc004bjt.1_Silent_p.L1182L|ASTN2_uc004bjp.1_Silent_p.L326L|ASTN2_uc004bjq.1_Silent_p.L285L|ASTN2_uc011lxr.1_Silent_p.L285L|ASTN2_uc011lxs.1_Silent_p.L285L|ASTN2_uc011lxt.1_Silent_p.L285L|ASTN2_uc004bjo.1_Silent_p.L14L	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1233	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GGACTCGGAACAGCATCGAGG	0.498													28	75					3.73808e-20	5.19764e-20	1	0	A	119202971	A	A	119202971	2	1	16	1	0	0	0	0	0	0	0	1	1067	465	17	4		4	ASTN2	9	119202971	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	6303719	119202971	22010460	276	3664											
TLR4	7099	broad.mit.edu	37	chr9	120470943	120470943	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacctgagctttaatcccCtgaggcatttaggcagctat	9	12	10	10	0	0	2	0	2	0	0	1	3	1	3	3	3	2	4	3	3	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:120470943C>T	uc004bjz.2	+	2	487	c.196C>T	c.(196-198)CTG>TTG	p.L66L	TLR4_uc004bka.2_Silent_p.L26L|TLR4_uc004bkb.2_Intron	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	66	LRR 1.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CTTTAATCCCCTGAGGCATTT	0.443													52	132					0	0	0	0	T	120470943	T	T	120470943	2	4	16	1	0	0	0	0	0	0	0	1	16019	680	24	4		4	TLR4	9	120470943	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1267972	120470943	20742488	277	3665											
OR1L1	26737	broad.mit.edu	37	chr9	125424532	125424532	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatccatcactttttctgcGatgatcaaccagtgctaaaa	12	13	5	11	1	4	1	3	1	1	0	5	2	5	1	2	0	3	1	2	0	3	3	rs142065229		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:125424532G>T	uc011lza.1	+	1	688	c.688G>T	c.(688-690)GAT>TAT	p.D230Y		NM_001005236	NP_001005236	Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L,	230	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						CTTTTTCTGCGATGATCAACC	0.428													59	123					4.96213e-28	7.34579e-28	1	0	T	125424532	T	T	125424532	3	4	16	1	0	0	0	0	1	0	0	0	11017	1058	37	3	540	3	OR1L1	9	125424532	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4953589	125424532	15788899	278	3666											
ADAMTS13	11093	broad.mit.edu	37	chr9	136302011	136302011	+	Frame_Shift_Del	DEL	G	-	-																															gccaggaccgacggccagccGctgcgctcctcccctggcgg																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr9:136302011delG	uc004cdv.3	+	12	1815	c.1371delG	c.(1369-1371)CCGfs	p.P457fs	ADAMTS13_uc004cdp.3_Intron|ADAMTS13_uc004cdt.1_Frame_Shift_Del_p.P457fs|ADAMTS13_uc004cdu.1_Frame_Shift_Del_p.P426fs|ADAMTS13_uc004cdw.3_Frame_Shift_Del_p.P457fs|ADAMTS13_uc004cdx.3_Frame_Shift_Del_p.P426fs|ADAMTS13_uc004cdy.1_RNA|ADAMTS13_uc004cdz.3_Frame_Shift_Del_p.P127fs|ADAMTS13_uc004cds.1_Intron|ADAMTS13_uc004cdr.1_RNA	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	457					cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		ACGGCCAGCCGCTGCGCTCCT	0.697													---	---	---								-	136302011	-	-	136302011	7	5	16	1	0	1	0	1	0	0	0	0	258	1074	38	0	1417	0	ADAMTS13	9	136302011	Frame_Shift_Del	DEL	G	TCGA-BA-6869-01A-11D-1870-08	10877479	136302011	4911420	279	3667											
SEPHS1	22929	broad.mit.edu	37	chr10	13378324	13378324	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccattgcatagaggtcactGaggacattggcacacgctat	11	9	10	11	1	1	2	1	1	0	1	1	3	1	3	1	3	1	3	1	3	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:13378324G>A	uc001imk.2	-	4	683	c.324C>T	c.(322-324)CTC>CTT	p.L108L	SEPHS1_uc001imh.2_Silent_p.L32L|SEPHS1_uc010qbs.1_Silent_p.L60L|SEPHS1_uc001imi.2_Silent_p.L108L|SEPHS1_uc001imj.2_Silent_p.L108L|SEPHS1_uc010qbt.1_Silent_p.L41L|SEPHS1_uc009xje.2_Silent_p.L108L	NM_012247	NP_036379	P49903	SPS1_HUMAN	selenophosphate synthetase 1	108					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			skin(1)	1						AGAGGTCACTGAGGACATTGG	0.517													10	69					0	0	0	0	A	13378324	A	A	13378324	2	1	16	1	0	0	0	0	0	0	0	1	14119	1277	45	2		2	SEPHS1	10	13378324	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08		13378324	122156423	280	3668											
C1QL3	389941	broad.mit.edu	37	chr10	16562732	16562732	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgctgatggccccggccgcGttcaggccgggcgccccggg	2	4	18	17	7	1	1	1	1	0	0	1	1	1	1	6	5	0	2	6	5	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:16562732G>A	uc001ioj.1	-	1	1273	c.333C>T	c.(331-333)AAC>AAT	p.N111N		NM_001010908	NP_001010908	Q5VWW1	C1QL3_HUMAN	complement component 1, q subcomponent-like 3	111	Collagen-like.					collagen				ovary(1)	1						CCCCGGCCGCGTTCAggccgg	0.632													6	48					0	0	0	0	A	16562732	A	A	16562732	2	1	16	1	0	0	0	0	0	0	0	1	1969	1136	40	1		1	C1QL3	10	16562732	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3184408	16562732	118972015	281	3669											
CUBN	8029	broad.mit.edu	37	chr10	16870935	16870935	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatggtgacaagccttccagCaggagcaacaaggacccact	13	5	11	12	0	0	1	0	1	0	0	1	4	1	3	3	3	4	2	3	3	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:16870935C>G	uc001ioo.2	-	66	10685	c.10633G>C	c.(10633-10635)GCT>CCT	p.A3545P		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3545	CUB 27.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGCCTTCCAGCAGGAGCAACA	0.522													65	44					0	0	0	0	G	16870935	G	G	16870935	3	3	16	1	0	0	0	0	1	0	0	0	4068	710	25	4	246	4	CUBN	10	16870935	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	308203	16870935	118663812	282	3670											
CUBN	8029	broad.mit.edu	37	chr10	16916401	16916401	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatcaccttgtcgtcactaaCggtgatggtatacagacagt	11	11	10	9	2	2	2	2	1	0	1	3	3	2	2	1	2	2	1	1	2	3	4	rs144314567		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:16916401C>A	uc001ioo.2	-	58	9260	c.9208G>T	c.(9208-9210)GTT>TTT	p.V3070F	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.V426F	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3070	CUB 23.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCGTCACTAACGGTGATGGTA	0.403													27	156					0.000117367	0.000123534	1	0	A	16916401	A	A	16916401	3	1	16	1	0	0	0	0	1	0	0	0	4068	536	19	3	1703	3	CUBN	10	16916401	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	45466	16916401	118618346	283	3671											
ARHGAP21	57584	broad.mit.edu	37	chr10	24880577	24880577	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacaatacttacaagaggCtcttcagcaccttcttctgt	11	12	6	12	0	4	2	1	0	3	2	4	2	4	2	1	1	3	2	1	1	4	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:24880577C>A	uc001isb.2	-	23	4525	c.4038G>T	c.(4036-4038)GAG>GAT	p.E1346D	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1345					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TTACAAGAGGCTCTTCAGCAC	0.393													33	161					8.73648e-17	1.17897e-16	1	0	A	24880577	A	A	24880577	3	1	16	1	0	0	0	0	1	0	0	0	871	796	28	4	1854	4	ARHGAP21	10	24880577	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	7964176	24880577	110654170	284	3672											
GPR158	57512	broad.mit.edu	37	chr10	25885717	25885717	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttggatccagaggacattcGggtaatgccagtactctatc	10	11	10	10	1	1	1	0	0	1	1	4	3	2	3	2	3	2	2	2	3	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:25885717G>A	uc001isj.2	+	10	2204	c.2144G>A	c.(2143-2145)CGG>CAG	p.R715Q	GPR158_uc001isk.2_Missense_Mutation_p.R90Q	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	715	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GAGGACATTCGGGTAATGCCA	0.488													87	63					0	0	0	0	A	25885717	A	A	25885717	3	1	16	1	0	0	0	0	1	0	0	0	6701	1130	39	1	2182	1	GPR158	10	25885717	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1005140	25885717	109649030	285	3673											
RET	5979	broad.mit.edu	37	chr10	43608405	43608405	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaacatttgccctcaggacTgcctccgtaagcagggttta	9	11	9	12	1	2	0	2	0	0	0	3	1	3	1	3	2	4	3	3	2	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:43608405T>A	uc001jal.2	+	9	1943	c.1753T>A	c.(1753-1755)TGC>AGC	p.C585S	RET_uc001jak.1_Missense_Mutation_p.C585S|RET_uc010qez.1_Missense_Mutation_p.C331S	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	585	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CCCTCAGGACTGCCTCCGTAA	0.572		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				13	27					0	0	0	0	A	43608405	A	A	43608405	3	1	16	1	0	0	0	0	1	0	0	0	13300	1580	55	5	1787	5	RET	10	43608405	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	17722688	43608405	91926342	286	3674											
C10orf72	196740	broad.mit.edu	37	chr10	50255035	50255035	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacggttacttaccagcgtgActtttctctgtggtttcagc	6	15	10	10	2	2	1	1	1	1	0	3	2	2	1	1	2	4	2	1	2	2	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:50255035A>C	uc001jhf.2	-	7	859	c.830T>G	c.(829-831)GTC>GGC	p.V277G		NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	277	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						TACCAGCGTGACTTTTCTCTG	0.453													60	143					0	0	0	0	C	50255035	C	C	50255035	3	2	16	1	0	0	0	0	1	0	0	0	1621	275	10	5	140	5	C10orf72	10	50255035	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	6646630	50255035	85279712	287	3675											
SGMS1	259230	broad.mit.edu	37	chr10	52103623	52103623	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgtctacgccaatgttgagGtgcccattggcatggccgtt	7	12	12	10	2	1	1	0	1	1	0	1	1	1	1	3	3	2	3	3	3	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:52103623G>A	uc001jje.2	-	7	1206	c.252C>T	c.(250-252)CAC>CAT	p.H84H	SGMS1_uc010qhk.1_Intron|SGMS1_uc009xot.1_Intron|SGMS1_uc009xou.1_Silent_p.H84H|SGMS1_uc010qhl.1_RNA	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	90					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						CAATGTTGAGGTGCCCATTGG	0.512													22	54					0	0	0	0	A	52103623	A	A	52103623	2	1	16	1	0	0	0	0	0	0	0	1	14279	1252	44	4		4	SGMS1	10	52103623	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1848588	52103623	83431124	288	3676											
ANK3	288	broad.mit.edu	37	chr10	61828625	61828625	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacaagctttaaggtctcaCcactaattcccttaaaatat	14	12	3	12	0	1	0	1	0	1	0	3	0	2	0	3	1	1	1	3	1	6	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:61828625C>T	uc001jky.2	-	37	12206	c.12014G>A	c.(12013-12015)GGT>GAT	p.G4005D	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	4005					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TAAGGTCTCACCACTAATTCC	0.368													38	88					0	0	0	0	T	61828625	T	T	61828625	3	4	16	1	0	0	0	0	1	0	0	0	622	507	18	4	1460	4	ANK3	10	61828625	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	9725002	61828625	73706122	289	3677											
LRRTM3	347731	broad.mit.edu	37	chr10	68687991	68687991	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcatcctgctggttatctaCgtgtcatggaagcggtaccc	7	12	11	11	2	3	0	2	0	1	0	4	1	4	1	2	3	4	3	2	3	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:68687991C>G	uc001jmz.1	+	2	1867	c.1317C>G	c.(1315-1317)TAC>TAG	p.Y439*	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Nonsense_Mutation_p.Y439*	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	439	Helical; (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TGGTTATCTACGTGTCATGGA	0.542													26	86					0	0	0	0	G	68687991	G	G	68687991	4	3	16	1	0	0	0	0	0	1	0	0	9091	547	19	3	1323	3	LRRTM3	10	68687991	Nonsense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	6859366	68687991	66846756	290	3678											
GRID1	2894	broad.mit.edu	37	chr10	87487768	87487768	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccctttgtagcgcttgggCtgtcctaggatgttctcagc	6	13	11	11	1	1	0	1	0	1	0	3	1	2	1	2	2	3	4	2	2	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:87487768C>A	uc001kdl.1	-	10	1478	c.1377G>T	c.(1375-1377)CAG>CAT	p.Q459H	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.Q30H	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	459	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGCGCTTGGGCTGTCCTAGGA	0.473										Multiple Myeloma(13;0.14)			38	54					1.22674e-20	1.71691e-20	1	0	A	87487768	A	A	87487768	3	1	16	1	0	0	0	0	1	0	0	0	6810	796	28	4	1680	4	GRID1	10	87487768	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	18799777	87487768	48046979	291	3679											
IFIT5	24138	broad.mit.edu	37	chr10	91177811	91177811	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaccaacttcttctttcctGcatcaccagatgggactttg	9	13	6	13	0	3	1	1	0	2	1	4	2	4	2	3	1	2	1	3	1	1	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:91177811G>A	uc010qnh.1	+	2	1086	c.855G>A	c.(853-855)CTG>CTA	p.L285L	IFIT5_uc010qng.1_Silent_p.L237L	NM_012420	NP_036552	Q13325	IFIT5_HUMAN	interferon-induced protein with	285							binding				0						CTTCTTTCCTGCATCACCAGA	0.423													33	35					0	0	0	0	A	91177811	A	A	91177811	2	1	16	1	0	0	0	0	0	0	0	1	7564	1306	46	4		4	IFIT5	10	91177811	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3690043	91177811	44356936	292	3680											
PLCE1	51196	broad.mit.edu	37	chr10	95995801	95995801	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggagctgcaatcgaagtctgGagacagacgaggaggacagc	13	4	16	8	2	1	2	0	0	1	2	2	8	1	5	0	4	3	2	0	4	2	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:95995801G>T	uc001kjk.2	+	7	2978	c.2344G>T	c.(2344-2346)GAG>TAG	p.E782*	PLCE1_uc010qnx.1_Nonsense_Mutation_p.E782*|PLCE1_uc001kjm.2_Nonsense_Mutation_p.E474*	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	782	Ras-GEF.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TCGAAGTCTGGAGACAGACGA	0.468													15	16					1.3612e-06	1.50436e-06	1	0	T	95995801	T	T	95995801	4	4	16	1	0	0	0	0	0	1	0	0	12089	1175	41	2	2652	2	PLCE1	10	95995801	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4817990	95995801	39538946	293	3681											
CYP2C8	1558	broad.mit.edu	37	chr10	96796938	96796938	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcagagaaacaatcccttTggtaactgcagtagtattga	13	11	10	7	0	0	2	0	1	0	1	1	3	1	2	1	2	3	5	1	2	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:96796938T>G	uc001kkb.2	-	9	1515	c.1420A>C	c.(1420-1422)AAA>CAA	p.K474Q	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.K404Q|CYP2C8_uc010qob.1_Missense_Mutation_p.K388Q|CYP2C8_uc010qoc.1_Missense_Mutation_p.K372Q	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	474					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	ACAATCCCTTTGGTAACTGCA	0.428													13	24					0	0	0	0	G	96796938	G	G	96796938	3	3	16	1	0	0	0	0	1	0	0	0	4184	1821	63	5	56	5	CYP2C8	10	96796938	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	801137	96796938	38737809	294	3682											
SLIT1	6585	broad.mit.edu	37	chr10	98770785	98770785	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaggcaggagtagctgttGacttcatccatacactgggc	10	9	12	10	0	1	2	1	1	0	1	2	3	2	3	1	3	2	4	1	3	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:98770785G>C	uc001kmw.2	-	31	3558	c.3306C>G	c.(3304-3306)GTC>GTG	p.V1102V		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1102	EGF-like 5.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		AGTAGCTGTTGACTTCATCCA	0.592													6	18					0	0	0	0	C	98770785	C	C	98770785	2	2	16	1	0	0	0	0	0	0	0	1	14803	1277	45	2		2	SLIT1	10	98770785	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1973847	98770785	36763962	295	3683											
SEC31B	25956	broad.mit.edu	37	chr10	102256959	102256959	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaccagccgctccacactcCctgagcacacataacagagt	12	5	6	18	1	0	2	0	1	0	1	2	2	2	2	5	0	3	2	5	0	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:102256959C>A	uc001krc.1	-	17	2171	c.2069G>T	c.(2068-2070)GGG>GTG	p.G690V	SEC31B_uc010qpo.1_Missense_Mutation_p.G689V|SEC31B_uc001krd.1_Missense_Mutation_p.G227V|SEC31B_uc001krf.1_Missense_Mutation_p.G227V|SEC31B_uc001kre.1_Missense_Mutation_p.G227V|SEC31B_uc001krg.1_Missense_Mutation_p.G259V	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	690	WD 7.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CTCCACACTCCCTGAGCACAC	0.582													15	43					7.93312e-07	8.81305e-07	1	0	A	102256959	A	A	102256959	3	1	16	1	0	0	0	0	1	0	0	0	14064	623	22	4	1510	4	SEC31B	10	102256959	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3486174	102256959	33277788	296	3684											
CALHM1	255022	broad.mit.edu	37	chr10	105218107	105218107	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgttgcccagtgcgctcacGggcacggcagtgcagaaggc	7	5	15	14	4	1	1	1	0	0	1	1	1	1	1	2	3	3	5	2	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:105218107G>A	uc001kxe.2	-	1	542	c.402C>T	c.(400-402)CCC>CCT	p.P134P		NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	134						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1						GTGCGCTCACGGGCACGGCAG	0.706													10	17					0	0	0	0	A	105218107	A	A	105218107	2	1	16	1	0	0	0	0	0	0	0	1	2594	1103	39	1		1	CALHM1	10	105218107	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2961148	105218107	30316640	297	3685											
NRAP	4892	broad.mit.edu	37	chr10	115350515	115350515	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actgggaccgactcttggcaAagtccttcttgtactcattg	8	13	9	11	1	3	0	1	0	2	0	4	2	4	1	2	2	1	2	2	2	2	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:115350515A>G	uc001laj.2	-	40	4942	c.4778T>C	c.(4777-4779)TTT>TCT	p.F1593S	NRAP_uc009xyb.2_Missense_Mutation_p.F346S|NRAP_uc001lak.2_Missense_Mutation_p.F1558S|NRAP_uc001lal.3_Missense_Mutation_p.F1593S	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1593	Nebulin 42.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		ACTCTTGGCAAAGTCCTTCTT	0.577													26	63					0	0	0	0	G	115350515	G	G	115350515	3	3	16	1	0	0	0	0	1	0	0	0	10692	14	1	5	426	5	NRAP	10	115350515	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	10132408	115350515	20184232	298	3686											
ATRNL1	26033	broad.mit.edu	37	chr10	117061411	117061411	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaaaaagccatgctctctGaggacatcatgttccaactg	12	10	8	11	0	2	1	1	1	1	0	4	2	3	2	2	1	4	3	2	1	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:117061411G>T	uc001lcg.2	+	17	3062	c.2676G>T	c.(2674-2676)CTG>CTT	p.L892L	ATRNL1_uc010qsm.1_Silent_p.L67L|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	892	PSI 4.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CATGCTCTCTGAGGACATCAT	0.378													16	48					0.000308642	0.000323267	1	0	T	117061411	T	T	117061411	2	4	16	1	0	0	0	0	0	0	0	1	1209	1277	45	2		2	ATRNL1	10	117061411	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1710896	117061411	18473336	299	3687											
PNLIPRP2	5408	broad.mit.edu	37	chr10	118386463	118386463	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacccaagccgtgcaaaacaTtcgggttgttggggcggaga	10	7	14	10	3	0	1	0	0	0	1	1	2	0	1	2	4	3	3	2	4	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:118386463T>A	uc001lcq.2	+	7	445	c.422T>A	c.(421-423)ATT>AAT	p.I141N	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	140					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		GTGCAAAACATTCGGGTTGTT	0.557													8	11					0	0	0	0	A	118386463	A	A	118386463	3	1	16	1	0	0	0	0	1	0	0	0	12206	1493	52	5	439	5	PNLIPRP2	10	118386463	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	1325052	118386463	17148284	300	3688											
BTBD16	118663	broad.mit.edu	37	chr10	124036332	124036332	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcggctggaacgccgggtCactggctcaaccaaccggtg	7	6	14	14	4	2	0	2	0	0	0	3	1	2	1	3	5	3	3	3	5	3	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:124036332C>A	uc001lgc.1	+	3	296	c.45C>A	c.(43-45)GTC>GTA	p.V15V	BTBD16_uc001lgd.1_Silent_p.V14V	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	15										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				AACGCCGGGTCACTGGCTCAA	0.478													22	92					1.96292e-10	2.36066e-10	1	0	A	124036332	A	A	124036332	2	1	16	1	0	0	0	0	0	0	0	1	1546	813	29	2		2	BTBD16	10	124036332	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	5649869	124036332	11498415	301	3689											
DMBT1	1755	broad.mit.edu	37	chr10	124399936	124399936	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatactccaatgacttcacGtctttgacttatgatctaat	11	15	4	11	1	3	3	1	3	2	0	4	3	4	3	2	0	1	0	2	0	4	5	rs112912048		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:124399936G>C	uc001lgk.1	+	52	7042	c.6936G>C	c.(6934-6936)ACG>ACC	p.T2312T	DMBT1_uc001lgl.1_Silent_p.T2302T|DMBT1_uc001lgm.1_Silent_p.T1684T|DMBT1_uc009xzz.1_Silent_p.T2311T|DMBT1_uc010qtx.1_Silent_p.T1032T|DMBT1_uc009yab.1_Silent_p.T1015T|DMBT1_uc009yac.1_Silent_p.T606T	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2312	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATGACTTCACGTCTTTGACTT	0.458													19	40					0	0	0	0	C	124399936	C	C	124399936	2	2	16	1	0	0	0	0	0	0	0	1	4599	1132	40	3		3	DMBT1	10	124399936	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	363604	124399936	11134811	302	3690											
FAM53B	9679	broad.mit.edu	37	chr10	126370314	126370314	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccgctggagcgtctcgcCagctctggtgttgaggcagg	5	8	17	11	3	2	1	0	1	2	0	3	2	2	2	2	5	2	4	2	5	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:126370314C>A	uc001lhv.1	-	4	1291	c.768G>T	c.(766-768)CTG>CTT	p.L256L	FAM53B_uc001lhu.1_Silent_p.L256L|FAM53B_uc001lhw.2_Silent_p.L256L	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	256										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		AGCGTCTCGCCAGCTCTGGTG	0.587													4	13					3.59834e-05	3.8251e-05	1	0	A	126370314	A	A	126370314	2	1	16	1	0	0	0	0	0	0	0	1	5612	581	21	4		4	FAM53B	10	126370314	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1970378	126370314	9164433	303	3691											
ADAM8	101	broad.mit.edu	37	chr10	135086312	135086312	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctgcccaccttgtccacgTgattcaccacctccagcacc	7	8	6	20	2	1	1	1	1	0	0	3	1	3	1	7	0	2	2	7	0	0	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr10:135086312T>A	uc010qva.1	-	7	629	c.578A>T	c.(577-579)CAC>CTC	p.H193L	ADAM8_uc010quz.1_Missense_Mutation_p.H232L|ADAM8_uc009ybi.2_Missense_Mutation_p.H232L|ADAM8_uc010qvb.1_Missense_Mutation_p.H207L|ADAM8_uc009ybj.1_RNA			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	193					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		CTTGTCCACGTGATTCACCAC	0.672													14	23					0	0	0	0	A	135086312	A	A	135086312	3	1	16	1	0	0	0	0	1	0	0	0	252	1696	59	5	1761	5	ADAM8	10	135086312	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	8715998	135086312	448435	304	3692											
PHRF1	57661	broad.mit.edu	37	chr11	608731	608731	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccggaggacgtcccggtcgcGgtcggggagccctggcagct	4	5	18	14	6	0	0	0	0	0	0	3	3	1	3	3	7	2	2	3	7	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:608731G>T	uc001lqe.2	+	14	3406	c.3275G>T	c.(3274-3276)CGG>CTG	p.R1092L	PHRF1_uc010qwc.1_Missense_Mutation_p.R1091L|PHRF1_uc010qwd.1_Missense_Mutation_p.R1090L|PHRF1_uc010qwe.1_Missense_Mutation_p.R1088L|PHRF1_uc009ybz.1_Missense_Mutation_p.R882L|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1092	Arg-rich.						RNA polymerase binding|zinc ion binding				0						TCCCGGTCGCGGTCGGGGAGC	0.632													12	19					1.61879e-10	1.95046e-10	1	0	T	608731	T	T	608731	3	4	16	1	0	0	0	0	1	0	0	0	11916	1116	39	3	3322	3	PHRF1	11	608731	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08		608731	134397785	305	3693											
MUC2	4583	broad.mit.edu	37	chr11	1078313	1078313	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gggaacatgcagaagatcaaCcagcccgatgtggtgtgtga	12	7	14	8	1	1	3	1	1	0	2	1	5	1	4	2	2	4	1	2	2	3	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:1078313C>A	uc001lsx.1	+	5	627	c.600C>A	c.(598-600)AAC>AAA	p.N200K		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	200	VWFD 1.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	AGAAGATCAACCAGCCCGATG	0.662													27	69					1.7881e-09	2.11082e-09	1	0	A	1078313	A	A	1078313	3	1	16	1	0	0	0	0	1	0	0	0	10028	506	18	4	618	4	MUC2	11	1078313	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	469582	1078313	133928203	306	3694											
OR52I2	143502	broad.mit.edu	37	chr11	4608485	4608485	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacggggctgctgctgaccaTggcttttgaccgctatgtag	6	11	14	10	2	0	2	0	2	0	0	0	3	0	2	2	3	2	6	2	3	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:4608485T>C	uc010qyh.1	+	1	443	c.443T>C	c.(442-444)ATG>ACG	p.M148T		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	148	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGCTGACCATGGCTTTTGAC	0.493													16	70					0	0	0	0	C	4608485	C	C	4608485	3	2	16	1	0	0	0	0	1	0	0	0	11175	1464	51	5	445	5	OR52I2	11	4608485	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	3530172	4608485	130398031	307	3695											
TRIM68	55128	broad.mit.edu	37	chr11	4621844	4621844	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctacattttgcttacataCtcccaggccccactcagacc	9	11	5	16	0	2	1	1	0	1	1	3	1	3	1	4	1	4	1	4	1	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:4621844C>G	uc001lzf.1	-	7	1358	c.1120G>C	c.(1120-1122)GTA>CTA	p.V374L	TRIM68_uc001lzg.1_Missense_Mutation_p.V151L|TRIM68_uc010qyj.1_RNA	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	374	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		TGCTTACATACTCCCAGGCCC	0.537													18	29					0	0	0	0	G	4621844	G	G	4621844	3	3	16	1	0	0	0	0	1	0	0	0	16608	565	20	4	341	4	TRIM68	11	4621844	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	13359	4621844	130384672	308	3696											
HBG2	3048	broad.mit.edu	37	chr11	5275578	5275578	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcagttcactcagctgggCaaaggtgcccttgagatcat	9	10	12	10	0	3	1	3	1	0	1	3	2	3	1	1	2	3	4	1	2	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:5275578C>T	uc001mai.1	-	2	696	c.259G>A	c.(259-261)GCC>ACC	p.A87T	HBG2_uc001mak.1_RNA|HBG2_uc001maj.1_Missense_Mutation_p.A87T	NM_000559	NP_000550	P69892	HBG2_HUMAN	A-gamma globin	87					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCAGCTGGGCAAAGGTGCCC	0.517													25	197					0	0	0	0	T	5275578	T	T	5275578	3	4	16	1	0	0	0	0	1	0	0	0	7022	710	25	4	192	4	HBG2	11	5275578	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	653734	5275578	129730938	309	3697											
OR51B6	390058	broad.mit.edu	37	chr11	5373081	5373081	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggagtcaggtgtcttgcttgCcatggcttatgactgtttca	6	15	12	8	0	3	1	2	1	1	0	3	2	3	2	1	3	2	3	1	3	1	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:5373081C>G	uc010qzb.1	+	1	344	c.344C>G	c.(343-345)GCC>GGC	p.A115G	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCTTGCTTGCCATGGCTTAT	0.473													13	63					0	0	0	0	G	5373081	G	G	5373081	3	3	16	1	0	0	0	0	1	0	0	0	11146	739	26	4	346	4	OR51B6	11	5373081	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	97503	5373081	129633435	310	3698											
DNHD1	144132	broad.mit.edu	37	chr11	6588904	6588904	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgagtgcctggcaggtgcCctggcagacttcaccactag	7	8	12	14	0	1	2	1	1	0	1	1	2	1	2	4	3	2	2	4	3	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:6588904C>T	uc001mdw.3	+	36	12729	c.12165C>T	c.(12163-12165)GCC>GCT	p.A4055A	DNHD1_uc001mea.3_Silent_p.A324A|DNHD1_uc001meb.2_Silent_p.A323A|DNHD1_uc001mec.2_Silent_p.A323A|DNHD1_uc010rao.1_Silent_p.A313A|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4055					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TGGCAGGTGCCCTGGCAGACT	0.617													16	38					0	0	0	0	T	6588904	T	T	6588904	2	4	16	1	0	0	0	0	0	0	0	1	4690	610	22	4		4	DNHD1	11	6588904	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1215823	6588904	128417612	311	3699											
DNHD1	144132	broad.mit.edu	37	chr11	6589744	6589744	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaagcaggaatgtaagcaCtgttcacagagattttcgtc	13	11	10	7	1	1	2	1	1	0	1	3	4	1	3	0	1	2	4	0	1	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:6589744C>G	uc001mdw.3	+	38	13163	c.12599C>G	c.(12598-12600)ACT>AGT	p.T4200S	DNHD1_uc001mea.3_Missense_Mutation_p.T469S|DNHD1_uc001meb.2_Missense_Mutation_p.T468S|DNHD1_uc001mec.2_Missense_Mutation_p.T468S|DNHD1_uc010rao.1_Missense_Mutation_p.T458S|DNHD1_uc009yfg.2_5'UTR	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4200					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		AATGTAAGCACTGTTCACAGA	0.463													24	48					0	0	0	0	G	6589744	G	G	6589744	3	3	16	1	0	0	0	0	1	0	0	0	4690	565	20	4	12750	4	DNHD1	11	6589744	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	840	6589744	128416772	312	3700											
OR6A2	8590	broad.mit.edu	37	chr11	6816345	6816345	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatctgtaagctctgctgTggacatatcagtgcatgaga	12	11	11	7	0	3	1	1	1	2	1	3	4	3	2	0	1	3	4	0	1	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:6816345T>C	uc001mes.1	-	1	795	c.595A>G	c.(595-597)ACA>GCA	p.T199A		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AGCTCTGCTGTGGACATATCA	0.468													37	98					0	0	0	0	C	6816345	C	C	6816345	3	2	16	1	0	0	0	0	1	0	0	0	11240	1696	59	5	392	5	OR6A2	11	6816345	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	226601	6816345	128190171	313	3701											
FAR1	84188	broad.mit.edu	37	chr11	13743308	13743308	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caataactcgtcttcacaaaGctatggtgtttcttgaatat	12	15	6	8	1	3	1	1	1	2	0	4	1	3	1	0	1	2	2	0	1	6	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:13743308G>T	uc001mld.2	+	10	1314	c.1159G>T	c.(1159-1161)GCT>TCT	p.A387S		NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	387					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						TCTTCACAAAGCTATGGTGTT	0.328													24	39					9.57634e-11	1.16479e-10	1	0	T	13743308	T	T	13743308	3	4	16	1	0	0	0	0	1	0	0	0	5706	971	34	4	1193	4	FAR1	11	13743308	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	6926963	13743308	121263208	314	3702											
INSC	387755	broad.mit.edu	37	chr11	15197552	15197552	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgggtgcacagcatgagcGtgcgtctgacctgccatgcc	7	7	13	14	3	1	2	0	2	1	0	1	2	1	2	3	1	6	2	3	1	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:15197552G>C	uc001mly.2	+	3	509	c.463G>C	c.(463-465)GTG>CTG	p.V155L	INSC_uc001mlz.2_Missense_Mutation_p.V108L|INSC_uc001mma.2_Missense_Mutation_p.V108L|INSC_uc010rcs.1_Missense_Mutation_p.V108L|INSC_uc001mmb.2_Missense_Mutation_p.V108L|INSC_uc001mmc.2_Missense_Mutation_p.V108L	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	155					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CAGCATGAGCGTGCGTCTGAC	0.627													8	10					0	0	0	0	C	15197552	C	C	15197552	3	2	16	1	0	0	0	0	1	0	0	0	7803	1145	40	3	473	3	INSC	11	15197552	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1454244	15197552	119808964	315	3703											
INSC	387755	broad.mit.edu	37	chr11	15260566	15260566	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagaaagctgcagtgaccCtggctcgtctcagccgagac	10	6	12	13	2	1	3	1	1	1	2	3	4	1	3	2	1	4	4	2	1	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:15260566C>A	uc001mly.2	+	11	1526	c.1480C>A	c.(1480-1482)CTG>ATG	p.L494M	INSC_uc001mlz.2_Missense_Mutation_p.L447M|INSC_uc001mma.2_Missense_Mutation_p.L447M|INSC_uc010rcs.1_Missense_Mutation_p.L482M|INSC_uc001mmb.2_Missense_Mutation_p.L447M|INSC_uc001mmc.2_Missense_Mutation_p.L405M	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	494					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						TGCAGTGACCCTGGCTCGTCT	0.602													16	26					1.15088e-07	1.29651e-07	1	0	A	15260566	A	A	15260566	3	1	16	1	0	0	0	0	1	0	0	0	7803	680	24	4	1522	4	INSC	11	15260566	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	63014	15260566	119745950	316	3704											
PLEKHA7	144100	broad.mit.edu	37	chr11	16834669	16834669	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtcacttacctttagatcCaggtactccaggtctttctt	8	16	6	11	0	3	1	1	0	2	1	5	1	5	1	3	2	2	1	3	2	3	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:16834669C>A	uc001mmo.2	-	13	2013	c.1998G>T	c.(1996-1998)CTG>CTT	p.L666L	PLEKHA7_uc010rcu.1_Silent_p.L666L|PLEKHA7_uc010rcv.1_Silent_p.L240L|PLEKHA7_uc001mmn.2_Silent_p.L374L	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	666	Interaction with CTNND1.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						CCTTTAGATCCAGGTACTCCA	0.468													15	34					7.93312e-07	8.81305e-07	1	0	A	16834669	A	A	16834669	2	1	16	1	0	0	0	0	0	0	0	1	12116	581	21	4		4	PLEKHA7	11	16834669	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1574103	16834669	118171847	317	3705											
SERGEF	26297	broad.mit.edu	37	chr11	18010157	18010157	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctcacctgtctgagcaacCaggtgtgtccatccactcca	8	10	8	15	0	2	1	1	1	2	0	6	1	5	1	5	1	2	1	5	1	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:18010157C>G	uc001mnm.2	-	8	911	c.831G>C	c.(829-831)CTG>CTC	p.L277L	SERGEF_uc009yhd.2_RNA|SERGEF_uc001mnn.2_Silent_p.L277L|SERGEF_uc010rcz.1_Silent_p.L163L|SERGEF_uc001mno.1_Silent_p.L163L	NM_012139	NP_036271	Q9UGK8	SRGEF_HUMAN	deafness locus associated putative guanine	277	RCC1 5.				negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1						TCTGAGCAACCAGGTGTGTCC	0.507													26	43					0	0	0	0	G	18010157	G	G	18010157	2	3	16	1	0	0	0	0	0	0	0	1	14142	581	21	4		4	SERGEF	11	18010157	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1175488	18010157	116996359	318	3706											
LDHC	3948	broad.mit.edu	37	chr11	18472631	18472631	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcccttttcaagaagaGtgcagaaacactttggaata	14	9	11	7	0	1	3	1	0	0	3	1	5	1	5	1	3	2	1	1	3	5	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:18472631G>T	uc001mon.3	+	8	1068	c.956G>T	c.(955-957)AGT>ATT	p.S319I	LDHC_uc001mom.3_Missense_Mutation_p.S319I|LDHC_uc009yhp.2_3'UTR|LDHC_uc001moo.3_Missense_Mutation_p.S203I|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_3'UTR	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	319					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	TTCAAGAAGAGTGCAGAAACA	0.388													29	55					1.2476e-16	1.68006e-16	1	0	T	18472631	T	T	18472631	3	4	16	1	0	0	0	0	1	0	0	0	8742	1029	36	4	982	4	LDHC	11	18472631	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	462474	18472631	116533885	319	3707											
ANO5	203859	broad.mit.edu	37	chr11	22271793	22271793	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttttcacaggaattattatGgagaaaaaattggtatctat	15	16	7	3	0	2	1	1	0	1	1	2	3	2	2	0	3	0	1	0	3	8	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:22271793G>A	uc001mqi.2	+	10	1206	c.889G>A	c.(889-891)GGA>AGA	p.G297R	ANO5_uc001mqj.2_Missense_Mutation_p.G296R	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	297	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						GAATTATTATGGAGAAAAAAT	0.244													10	20					0	0	0	0	A	22271793	A	A	22271793	3	1	16	1	0	0	0	0	1	0	0	0	700	1349	47	4	927	4	ANO5	11	22271793	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3799162	22271793	112734723	320	3708											
MAPK8IP1	9479	broad.mit.edu	37	chr11	45924289	45924289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacccctccacggcagggcGgccgcacccctccatcagtg	6	5	10	20	3	1	0	1	0	0	0	3	0	3	0	7	3	1	2	7	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:45924289G>A	uc001nbr.2	+	5	1141	c.971G>A	c.(970-972)CGG>CAG	p.R324Q		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	324					vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		ACGGCAGGGCGGCCGCACCCC	0.711													7	10					0	0	0	0	A	45924289	A	A	45924289	3	1	16	1	0	0	0	0	1	0	0	0	9337	1116	39	1	989	1	MAPK8IP1	11	45924289	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	23652496	45924289	89082227	321	3709											
OR4B1	119765	broad.mit.edu	37	chr11	48239279	48239279	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagcaaaaaggagaatccAgggagggagtgaaaaaagag	19	3	16	3	0	0	3	0	1	0	2	1	7	1	6	1	4	1	1	1	4	6	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:48239279A>T	uc010rhs.1	+	1	918	c.918A>T	c.(916-918)CCA>CCT	p.P306P		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P306T(1)		skin(2)|ovary(1)|pancreas(1)	4						AGGAGAATCCAGGGAGGGAGT	0.408													11	31					0	0	0	0	T	48239279	T	T	48239279	2	4	16	1	0	0	0	0	0	0	0	1	11098	175	7	5		5	OR4B1	11	48239279	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	2314990	48239279	86767237	322	3710											
OR5M3	219482	broad.mit.edu	37	chr11	56237369	56237369	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gggaatatgtgaagttaatgCcggcaagtatgatcattgta	13	12	12	4	1	1	2	1	2	0	0	1	3	1	3	1	2	1	4	1	2	7	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:56237369C>A	uc010rjk.1	-	1	605	c.605G>T	c.(604-606)GGC>GTC	p.G202V		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAAGTTAATGCCGGCAAGTAT	0.418													35	80					1.90571e-15	2.54491e-15	1	0	A	56237369	A	A	56237369	3	1	16	1	0	0	0	0	1	0	0	0	11229	739	26	4	320	4	OR5M3	11	56237369	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	7998090	56237369	78769147	323	3711											
OR5M8	219484	broad.mit.edu	37	chr11	56258161	56258161	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttttgcctgccctctgtaGagcgaatctttaaaatagca	10	14	7	10	1	2	1	0	0	2	1	2	2	2	1	2	0	4	2	2	0	5	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:56258161G>T	uc001nix.1	-	1	686	c.686C>A	c.(685-687)TCT>TAT	p.S229Y		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					GCCCTCTGTAGAGCGAATCTT	0.413													17	34					4.14922e-12	5.215e-12	1	0	T	56258161	T	T	56258161	3	4	16	1	0	0	0	0	1	0	0	0	11230	942	33	2	253	2	OR5M8	11	56258161	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	20792	56258161	78748355	324	3712											
OR5AR1	219493	broad.mit.edu	37	chr11	56431878	56431878	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgccttaaggctttctcCacctgcgggtctcaccttac	5	11	9	16	2	2	0	1	0	2	0	4	0	2	0	5	3	2	1	5	3	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:56431878C>A	uc010rjm.1	+	1	717	c.717C>A	c.(715-717)TCC>TCA	p.S239S		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	239	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGCTTTCTCCACCTGCGGGT	0.483													24	90					2.21704e-12	2.79748e-12	1	0	A	56431878	A	A	56431878	2	1	16	1	0	0	0	0	0	0	0	1	11199	581	21	4		4	OR5AR1	11	56431878	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	173717	56431878	78574638	325	3713											
OR9I1	219954	broad.mit.edu	37	chr11	57886521	57886521	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgggattcatggccacggtAtagagcagtgggttgcgaat	9	10	15	7	2	1	1	1	0	0	1	1	3	1	2	1	4	2	3	1	4	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:57886521A>G	uc001nml.1	-	1	396	c.396T>C	c.(394-396)TAT>TAC	p.Y132Y	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				TGGCCACGGTATAGAGCAGTG	0.557													12	38					0	0	0	0	G	57886521	G	G	57886521	2	3	16	1	0	0	0	0	0	0	0	1	11307	456	16	5		5	OR9I1	11	57886521	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	1454643	57886521	77119995	326	3714											
MS4A4A	51338	broad.mit.edu	37	chr11	60073587	60073587	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctagggtctggatggcatGgtgctcctcctaagtgtgct	5	13	13	10	0	1	0	0	0	1	0	4	1	4	1	3	4	2	3	3	4	2	2	rs148827848		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:60073587G>T	uc001noz.2	+	6	571	c.561G>T	c.(559-561)ATG>ATT	p.M187I	MS4A4A_uc001npa.2_Missense_Mutation_p.M168I|MS4A4A_uc001npb.2_Missense_Mutation_p.M168I|MS4A4A_uc001npc.2_Missense_Mutation_p.M115I	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	187	Helical; (Potential).					integral to membrane	receptor activity				0						TGGATGGCATGGTGCTCCTCC	0.458													32	78					1.22384e-17	1.66556e-17	1	0	T	60073587	T	T	60073587	3	4	16	1	0	0	0	0	1	0	0	0	9915	1348	47	4	583	4	MS4A4A	11	60073587	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2187066	60073587	74932929	327	3715											
FAM86C	55199	broad.mit.edu	37	chr11	71507140	71507140	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcctgccgggagcaccagCgggctcctcaattctacatg	7	8	11	15	2	2	0	1	0	1	0	3	1	3	1	4	2	5	2	4	2	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:71507140C>A	uc001oqv.3	+	4	365	c.339C>A	c.(337-339)AGC>AGA	p.S113R	FAM86C_uc009ysr.2_Missense_Mutation_p.S106R|FAM86C_uc001oqw.3_Missense_Mutation_p.S79R|FAM86C_uc009yss.2_RNA|FAM86C_uc010rqq.1_RNA|uc001oqx.1_Intron	NM_018172	NP_060642	Q9NVL1	FA86C_HUMAN	hypothetical protein LOC55199 isoform 1	113											0						GGAGCACCAGCGGGCTCCTCA	0.632													46	119					7.88023e-25	1.14801e-24	1	0	A	71507140	A	A	71507140	3	1	16	1	0	0	0	0	1	0	0	0	5678	767	27	3	438	3	FAM86C	11	71507140	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	11433553	71507140	63499376	328	3716											
GDPD4	220032	broad.mit.edu	37	chr11	76940195	76940195	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaattatatatatacttacCagtgaaaacaaaatatggca	21	11	4	5	0	0	1	0	1	0	0	0	1	0	1	1	1	3	1	1	1	13	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:76940195C>A	uc001oyf.2	-	14	1723	c.1472G>T	c.(1471-1473)TGG>TTG	p.W491L		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	491	Cytoplasmic (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						atataCTTACCAGTGAAAACA	0.299													8	21					5.18039e-06	5.65695e-06	1	0	A	76940195	A	A	76940195	3	1	16	1	0	0	0	0	1	0	0	0	6363	608	21	4	102	4	GDPD4	11	76940195	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	5433055	76940195	58066321	329	3717											
FZD4	8322	broad.mit.edu	37	chr11	86662821	86662821	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctgctgccaaaaaccaaGtgagtgtcagaataacccac	14	7	8	12	0	1	2	1	1	0	1	2	2	2	2	4	0	4	1	4	0	5	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:86662821G>A	uc001pce.2	-	2	1283	c.977C>T	c.(976-978)ACT>ATT	p.T326I	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	326	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAAAAACCAAGTGAGTGTCAG	0.453													13	23					0	0	0	0	A	86662821	A	A	86662821	3	1	16	1	0	0	0	0	1	0	0	0	6166	1029	36	4	640	4	FZD4	11	86662821	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	9722626	86662821	48343695	330	3718											
GRM5	2915	broad.mit.edu	37	chr11	88258477	88258477	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccactcatagtttgcttacCtgctcattgttgctctccca	6	15	6	14	0	3	0	2	0	1	0	4	0	3	0	3	0	4	5	3	0	2	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:88258477C>A	uc001pcq.2	-	8	2926	c.2726G>T	c.(2725-2727)AGT>ATT	p.S909I	GRM5_uc009yvm.2_Intron	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	909	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GTTTGCTTACCTGCTCATTGT	0.507													73	191					2.37984e-18	3.25262e-18	1	0	A	88258477	A	A	88258477	3	1	16	1	0	0	0	0	1	0	0	0	6839	695	24	4	920	4	GRM5	11	88258477	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1595656	88258477	46748039	331	3719											
FAT3	120114	broad.mit.edu	37	chr11	92087428	92087428	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggatttcttgacttttattCaattaatagacagggaccat	12	16	7	6	0	2	2	1	1	1	1	2	4	2	4	1	2	0	0	1	2	4	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:92087428C>T	uc001pdj.3	+	1	2167	c.2150C>T	c.(2149-2151)TCA>TTA	p.S717L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	717	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GACTTTTATTCAATTAATAGA	0.398										TCGA Ovarian(4;0.039)			49	145					0	0	0	0	T	92087428	T	T	92087428	3	4	16	1	0	0	0	0	1	0	0	0	5723	838	29	2	2152	2	FAT3	11	92087428	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3828951	92087428	42919088	332	3720											
FAT3	120114	broad.mit.edu	37	chr11	92564960	92564960	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggacagtccctgtcctcTctcactactgtcaccatcac	7	11	5	18	0	4	0	3	0	1	0	7	1	6	1	4	1	1	0	4	1	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:92564960T>A	uc001pdj.3	+	13	9671	c.9654T>A	c.(9652-9654)TCT>TCA	p.S3218S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3218	Cadherin 29.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCCTGTCCTCTCTCACTACTG	0.577										TCGA Ovarian(4;0.039)			11	11					0	0	0	0	A	92564960	A	A	92564960	2	1	16	1	0	0	0	0	0	0	0	1	5723	1538	54	5		5	FAT3	11	92564960	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	477532	92564960	42441556	333	3721											
CNTN5	53942	broad.mit.edu	37	chr11	99715885	99715885	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagtttgatagatggcacCttcattataagcaatccaag	14	12	7	8	0	1	2	1	1	0	1	2	2	2	2	2	1	2	3	2	1	6	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:99715885C>A	uc001pga.2	+	6	807	c.468C>A	c.(466-468)ACC>ACA	p.T156T	CNTN5_uc009ywv.1_Silent_p.T156T|CNTN5_uc001pfz.2_Silent_p.T156T|CNTN5_uc001pgb.2_Silent_p.T82T	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	156	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TAGATGGCACCTTCATTATAA	0.373													35	69					8.53417e-09	9.91016e-09	1	0	A	99715885	A	A	99715885	2	1	16	1	0	0	0	0	0	0	0	1	3659	668	24	4		4	CNTN5	11	99715885	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	7150925	99715885	35290631	334	3722											
CNTN5	53942	broad.mit.edu	37	chr11	99941252	99941252	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactggaaaacccagacccaCgtatcgttggctgaagaatg	13	8	10	10	2	0	3	0	1	0	2	1	4	0	4	2	2	2	3	2	2	6	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:99941252C>G	uc001pga.2	+	11	1598	c.1259C>G	c.(1258-1260)ACG>AGG	p.T420R	CNTN5_uc009ywv.1_Missense_Mutation_p.T420R|CNTN5_uc001pfz.2_Missense_Mutation_p.T420R|CNTN5_uc001pgb.2_Missense_Mutation_p.T346R	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	420	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCCAGACCCACGTATCGTTGG	0.478													16	30					0	0	0	0	G	99941252	G	G	99941252	3	3	16	1	0	0	0	0	1	0	0	0	3659	536	19	3	1293	3	CNTN5	11	99941252	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	225367	99941252	35065264	335	3723											
CNTN5	53942	broad.mit.edu	37	chr11	99944884	99944884	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttttttaatagcttcagctCccacttttgcactgaatcaa	10	16	4	11	0	2	1	2	1	0	0	3	1	3	1	1	0	3	3	1	0	4	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:99944884C>A	uc001pga.2	+	13	1777	c.1438C>A	c.(1438-1440)CCC>ACC	p.P480T	CNTN5_uc009ywv.1_Missense_Mutation_p.P480T|CNTN5_uc001pfz.2_Missense_Mutation_p.P480T|CNTN5_uc001pgb.2_Missense_Mutation_p.P406T	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	480	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGCTTCAGCTCCCACTTTTGC	0.368													10	30					5.50884e-06	5.9648e-06	1	0	A	99944884	A	A	99944884	3	1	16	1	0	0	0	0	1	0	0	0	3659	855	30	2	1480	2	CNTN5	11	99944884	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3632	99944884	35061632	336	3724											
MMP10	4319	broad.mit.edu	37	chr11	102649421	102649421	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccataaagcccaggtccagGtgggtaggcatgagccaaac	12	6	12	11	0	0	1	0	1	0	0	2	1	2	1	4	4	3	2	4	4	4	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:102649421G>A	uc001phg.1	-	4	578	c.556C>T	c.(556-558)CCT>TCT	p.P186S		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	186					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		CCAGGTCCAGGTGGGTAGGCA	0.423													23	42					0	0	0	0	A	102649421	A	A	102649421	3	1	16	1	0	0	0	0	1	0	0	0	9702	1261	44	4	902	4	MMP10	11	102649421	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2704537	102649421	32357095	337	3725											
CARD16	114769	broad.mit.edu	37	chr11	104912149	104912149	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgataatttatgagttccaGtttgcaactctttacctaaa	13	16	5	7	0	1	2	0	2	1	0	2	2	2	2	2	0	3	3	2	0	6	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:104912149G>C	uc001pip.1	-	3	599	c.572C>G	c.(571-573)ACT>AGT	p.T191S	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_3'UTR	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	191					regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1						ATGAGTTCCAGTTTGCAACTC	0.393													21	35					0	0	0	0	C	104912149	C	C	104912149	3	2	16	1	0	0	0	0	1	0	0	0	2659	1029	36	4	25	4	CARD16	11	104912149	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2262728	104912149	30094367	338	3726											
GUCY1A2	2977	broad.mit.edu	37	chr11	106888648	106888648	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggccgggctgggctccagcGgcccgggcgggctccggctg	1	4	20	16	6	0	0	0	0	0	0	2	0	2	0	4	7	1	4	4	7	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:106888648G>C	uc001pjg.1	-	1	524	c.134C>G	c.(133-135)CCG>CGG	p.P45R	GUCY1A2_uc010rvo.1_Missense_Mutation_p.P45R|GUCY1A2_uc009yxn.1_Missense_Mutation_p.P45R	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	45					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GGGCTCCAGCGGCCCGGGCGG	0.473													2	5					0	0	0	0	C	106888648	C	C	106888648	3	2	16	1	0	0	0	0	1	0	0	0	6932	1116	39	3	2096	3	GUCY1A2	11	106888648	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1976499	106888648	28117868	339	3727											
DRD2	1813	broad.mit.edu	37	chr11	113295162	113295162	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgcgaggctgacgatcaggTagttggtggtggtctgcagc	6	10	17	8	2	2	1	1	1	1	0	2	3	2	1	0	5	3	4	0	5	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:113295162T>A	uc001pnz.2	-	1	533	c.212A>T	c.(211-213)TAC>TTC	p.Y71F	DRD2_uc010rwv.1_Missense_Mutation_p.Y71F|DRD2_uc001poa.3_Missense_Mutation_p.Y71F|DRD2_uc001pob.3_Missense_Mutation_p.Y71F|DRD2_uc009yyr.1_Missense_Mutation_p.Y71F	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	71	Helical; Name=2; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GACGATCAGGTAGTTGGTGGT	0.637													16	38					0	0	0	0	A	113295162	A	A	113295162	3	1	16	1	0	0	0	0	1	0	0	0	4779	1638	57	5	1147	5	DRD2	11	113295162	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	6406514	113295162	21711354	340	3728											
RNF214	257160	broad.mit.edu	37	chr11	117153235	117153235	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gactggcagaacatgagcggGtggcagcaagtactcaggtg	11	6	16	8	1	1	2	1	1	0	1	1	3	1	2	0	4	4	4	0	4	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:117153235G>A	uc001pqt.2	+	12	1873	c.1828G>A	c.(1828-1830)GTG>ATG	p.V610M	RNF214_uc001pqu.2_Missense_Mutation_p.V610M|RNF214_uc010rxf.1_Missense_Mutation_p.V455M	NM_207343	NP_997226	Q8ND24	RN214_HUMAN	ring finger protein 214	610							zinc ion binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		ACATGAGCGGGTGGCAGCAAG	0.522													14	18					0	0	0	0	A	117153235	A	A	117153235	3	1	16	1	0	0	0	0	1	0	0	0	13543	1261	44	4	1870	4	RNF214	11	117153235	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3858073	117153235	17853281	341	3729											
CEP164	22897	broad.mit.edu	37	chr11	117253621	117253621	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagaggatcctgaggagaagGtggcggtcagccccaccccg	9	4	15	13	2	1	3	1	1	0	2	2	5	2	4	5	5	1	0	5	5	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:117253621G>C	uc001prc.2	+	14	1834	c.1687G>C	c.(1687-1689)GTG>CTG	p.V563L	CEP164_uc001prb.2_Missense_Mutation_p.V566L|CEP164_uc010rxk.1_Missense_Mutation_p.V537L|CEP164_uc001prf.2_RNA|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_5'Flank	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	563	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		TGAGGAGAAGGTGGCGGTCAG	0.637													17	20					0	0	0	0	C	117253621	C	C	117253621	3	2	16	1	0	0	0	0	1	0	0	0	3264	1261	44	4	1733	4	CEP164	11	117253621	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	100386	117253621	17752895	342	3730											
SORL1	6653	broad.mit.edu	37	chr11	121475024	121475024	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cggacgagagcgatgaaaagGcctgcagtggtgagtgccgg	10	5	18	8	4	0	3	0	2	0	1	0	6	0	4	2	4	3	1	2	4	2	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:121475024G>A	uc001pxx.2	+	33	4722	c.4642G>A	c.(4642-4644)GCC>ACC	p.A1548T	SORL1_uc010rzp.1_Missense_Mutation_p.A394T|SORL1_uc010rzq.1_Missense_Mutation_p.A163T	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1548	Extracellular (Potential).|LDL-receptor class A 11.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CGATGAAAAGGCCTGCAGTGG	0.547													20	37					0	0	0	0	A	121475024	A	A	121475024	3	1	16	1	0	0	0	0	1	0	0	0	14998	1203	42	4	4772	4	SORL1	11	121475024	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4221403	121475024	13531492	343	3731											
OR10G4	390264	broad.mit.edu	37	chr11	123886995	123886995	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaggcgcagagcctttcaGacctgtgcctcccactgtat	7	9	12	13	1	1	2	1	0	0	2	2	3	2	3	4	2	2	2	4	2	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:123886995G>T	uc010sac.1	+	1	714	c.714G>T	c.(712-714)CAG>CAT	p.Q238H		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GAGCCTTTCAGACCTGTGCCT	0.542													22	57					1.50039e-11	1.86025e-11	1	0	T	123886995	T	T	123886995	3	4	16	1	0	0	0	0	1	0	0	0	10955	933	33	2	716	2	OR10G4	11	123886995	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2411971	123886995	11119521	344	3732											
OR8D2	283160	broad.mit.edu	37	chr11	124189698	124189698	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgggacatgacaatattGtaaagcagtgggcgacagat	13	9	13	6	1	0	2	0	1	0	1	0	4	0	3	0	2	1	2	0	2	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:124189698G>T	uc010sah.1	-	1	396	c.396C>A	c.(394-396)TAC>TAA	p.Y132*		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TGACAATATTGTAAAGCAGTG	0.443													11	32					2.80697e-09	3.30141e-09	1	0	T	124189698	T	T	124189698	4	4	16	1	0	0	0	0	0	1	0	0	11286	1372	48	4	542	4	OR8D2	11	124189698	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	302703	124189698	10816818	345	3733											
FAM118B	79607	broad.mit.edu	37	chr11	126110725	126110725	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaactaagaagcctcgagAacttgtgctagtgattggaa	16	9	10	6	1	0	3	0	1	0	2	1	5	0	4	1	1	4	1	1	1	7	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:126110725A>C	uc001qdf.2	+	4	308	c.125A>C	c.(124-126)GAA>GCA	p.E42A	FAM118B_uc009zca.2_Missense_Mutation_p.E46A|FAM118B_uc001qdg.2_Missense_Mutation_p.E42A	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	42											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		AAGCCTCGAGAACTTGTGCTA	0.443													64	148					0	0	0	0	C	126110725	C	C	126110725	3	2	16	1	0	0	0	0	1	0	0	0	5440	246	9	5	131	5	FAM118B	11	126110725	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	1921027	126110725	8895791	346	3734											
KCNJ1	3758	broad.mit.edu	37	chr11	128709440	128709440	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttcattcccagcgtcaacTacaaagttgatattgatctg	11	15	6	9	1	3	2	2	2	1	0	4	2	4	2	1	0	3	1	1	0	4	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:128709440T>A	uc001qeo.1	-	2	807	c.756A>T	c.(754-756)GTA>GTT	p.V252V	KCNJ1_uc001qep.1_Silent_p.V233V|KCNJ1_uc001qeq.1_Silent_p.V233V|KCNJ1_uc001qer.1_Silent_p.V233V|KCNJ1_uc001qes.1_Silent_p.V233V	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	252	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CAGCGTCAACTACAAAGTTGA	0.428													40	92					0	0	0	0	A	128709440	A	A	128709440	2	1	16	1	0	0	0	0	0	0	0	1	8082	1509	53	5		5	KCNJ1	11	128709440	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	2598715	128709440	6297076	347	3735											
OPCML	4978	broad.mit.edu	37	chr11	132307171	132307171	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagcgacatcgttcaacgcGctgcattcgtactccccgga	8	8	10	15	6	1	0	1	0	0	0	4	2	2	1	2	1	4	5	2	1	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr11:132307171G>C	uc001qgs.2	-	4	659	c.609C>G	c.(607-609)AGC>AGG	p.S203R	OPCML_uc001qgu.2_Missense_Mutation_p.S196R|OPCML_uc010sck.1_Missense_Mutation_p.S203R|OPCML_uc001qgt.2_Missense_Mutation_p.S202R|OPCML_uc010scl.1_Missense_Mutation_p.S162R	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	203	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CGTTCAACGCGCTGCATTCGT	0.542													26	42					0	0	0	0	C	132307171	C	C	132307171	3	2	16	1	0	0	0	0	1	0	0	0	10928	1078	38	3	444	3	OPCML	11	132307171	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3597731	132307171	2699345	348	3736											
LEPREL2	10536	broad.mit.edu	37	chr12	6943184	6943184	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgggctgctcaccccagccGagtgtggggtgctgctgcag	5	8	16	12	1	1	0	1	0	0	0	1	1	1	0	3	3	5	5	3	3	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:6943184G>T	uc001qra.1	+	11	1463	c.1429G>T	c.(1429-1431)GAG>TAG	p.E477*	LEPREL2_uc001qqz.1_Nonsense_Mutation_p.E284*|LEPREL2_uc001qrb.1_Nonsense_Mutation_p.E284*	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	477					negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CACCCCAGCCGAGTGTGGGGT	0.587													28	55					1.17739e-12	1.50042e-12	1	0	T	6943184	T	T	6943184	4	4	16	1	0	0	0	0	0	1	0	0	8771	1059	37	3	1462	3	LEPREL2	12	6943184	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08		6943184	126908711	349	3737											
CD163	9332	broad.mit.edu	37	chr12	7640427	7640427	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttccttctgggcggggtgcTactgggcagagtgaaagatg	7	10	17	7	1	1	3	0	1	1	2	2	3	2	3	1	4	2	3	1	4	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:7640427T>G	uc001qsz.3	-	7	1805	c.1677A>C	c.(1675-1677)GTA>GTC	p.V559V	CD163_uc001qta.3_Silent_p.V559V|CD163_uc009zfw.2_Silent_p.V559V	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	559	SRCR 5.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GGCGGGGTGCTACTGGGCAGA	0.502													32	58					0	0	0	0	G	7640427	G	G	7640427	2	3	16	1	0	0	0	0	0	0	0	1	2982	1509	53	5		5	CD163	12	7640427	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	697243	7640427	126211468	350	3738											
KLRB1	3820	broad.mit.edu	37	chr12	9751243	9751243	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgggcagtttaagagacccGgtctctctaaagtaaaaaac	14	10	9	8	1	2	1	0	0	2	1	3	2	2	1	1	2	1	3	1	2	6	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:9751243G>T	uc010sgt.1	-	4	328	c.266C>A	c.(265-267)CCG>CAG	p.P89Q		NM_002258	NP_002249	Q12918	KLRB1_HUMAN	killer cell lectin-like receptor subfamily B,	89	Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0						TAAGAGACCCGGTCTCTCTAA	0.373													32	72					4.31634e-10	5.16189e-10	1	0	T	9751243	T	T	9751243	3	4	16	1	0	0	0	0	1	0	0	0	8453	1116	39	3	422	3	KLRB1	12	9751243	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2110816	9751243	124100652	351	3739											
TAS2R8	50836	broad.mit.edu	37	chr12	10959383	10959383	+	Frame_Shift_Del	DEL	C	-	-																															ggttcagtactattacaatgCcatttacaaccattacactg																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:10959383delC	uc010shh.1	-	1	197	c.197delG	c.(196-198)GGCfs	p.G66fs		NM_023918	NP_076407	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	66	Helical; Name=2; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			ovary(2)	2						TATTACAATGCCATTTACAAC	0.318													---	---	---								-	10959383	-	-	10959383	7	5	16	1	0	1	0	1	0	0	0	0	15653	739	26	0	735	0	TAS2R8	12	10959383	Frame_Shift_Del	DEL	C	TCGA-BA-6869-01A-11D-1870-08	1208140	10959383	122892512	352	3740											
GUCY2C	2984	broad.mit.edu	37	chr12	14766128	14766128	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttatagctggctacccGtctgggtttttggcttctta	4	20	9	8	1	2	0	0	0	2	0	2	0	2	0	1	3	2	4	1	3	4	9	rs140551603		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:14766128G>A	uc001rcd.2	-	27	3282	c.3145C>T	c.(3145-3147)CGG>TGG	p.R1049W		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	1049	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						CTGGCTACCCGTCTGGGTTTT	0.433													74	158					0	0	0	0	A	14766128	A	A	14766128	3	1	16	1	0	0	0	0	1	0	0	0	6935	1144	40	1	80	1	GUCY2C	12	14766128	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3806745	14766128	119085767	353	3741											
ART4	420	broad.mit.edu	37	chr12	14993877	14993877	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacaaaatagccacagcgtGtgtggtagtcatgttctggg	12	10	12	7	1	2	0	1	0	1	0	2	0	2	0	1	2	3	2	1	2	5	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:14993877G>T	uc001rcl.1	-	2	721	c.355C>A	c.(355-357)CAC>AAC	p.H119N	ART4_uc009zid.1_Intron|ART4_uc009zie.1_Intron|ART4_uc001rcm.1_Missense_Mutation_p.H119N	NM_021071	NP_066549	Q93070	NAR4_HUMAN	ADP-ribosyltransferase 4 precursor	119					arginine metabolic process|protein ADP-ribosylation	anchored to membrane|plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity				0						GCCACAGCGTGTGTGGTAGTC	0.438													44	87					4.18559e-23	5.97542e-23	1	0	T	14993877	T	T	14993877	3	4	16	1	0	0	0	0	1	0	0	0	1001	1377	48	4	597	4	ART4	12	14993877	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	227749	14993877	118858018	354	3742											
PTPRO	5800	broad.mit.edu	37	chr12	15654948	15654948	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atattgacctggttaccaccCaaaccacccactgcttttga	11	11	5	14	0	0	2	0	2	0	0	0	2	0	2	5	1	3	2	5	1	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:15654948C>G	uc001rcv.1	+	5	1230	c.1056C>G	c.(1054-1056)CCC>CCG	p.P352P	PTPRO_uc001rcw.1_Silent_p.P352P|PTPRO_uc001rcu.1_Silent_p.P352P	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	352	Fibronectin type-III 4.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GGTTACCACCCAAACCACCCA	0.418													21	63					0	0	0	0	G	15654948	G	G	15654948	2	3	16	1	0	0	0	0	0	0	0	1	12874	581	21	4		4	PTPRO	12	15654948	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	661071	15654948	118196947	355	3743											
SLCO1C1	53919	broad.mit.edu	37	chr12	20876190	20876190	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agggccaactttgtgatcggTatgctcatctgcctttcatg	7	14	10	10	1	3	1	2	1	1	0	4	1	3	1	2	2	3	2	2	2	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:20876190T>G	uc001rej.3	+	10	1541	c.1186_splice	c.e10+2	p.G396_splice	SLCO1C1_uc010sii.1_Splice_Site_p.G396_splice|SLCO1C1_uc010sij.1_Splice_Site_p.G347_splice|SLCO1C1_uc009zip.2_Splice_Site_p.G230_splice|SLCO1C1_uc001rei.2_Splice_Site_p.G396_splice|SLCO1C1_uc010sik.1_Splice_Site_p.G278_splice	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,						sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TTGTGATCGGTATGCTCATCT	0.443													17	40					0	0	0	0	G	20876190	G	G	20876190	5	3	16	1	0	0	0	0	0	0	1	0	14789	1652	57	5	1218	5	SLCO1C1	12	20876190	Splice_Site	SNP	T	TCGA-BA-6869-01A-11D-1870-08	5221242	20876190	112975705	356	3744											
RECQL	5965	broad.mit.edu	37	chr12	21629893	21629893	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagctttacaatatcctcaaTaaaatcttcagtgtttgagg	13	14	7	7	0	3	1	2	1	1	0	4	2	4	1	1	1	2	2	1	1	6	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:21629893T>C	uc001rex.2	-	9	1249	c.901A>G	c.(901-903)ATT>GTT	p.I301V	RECQL_uc001rey.2_Missense_Mutation_p.I301V	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	301	Helicase C-terminal.				DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						ATATCCTCAATAAAATCTTCA	0.338								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					13	39					0	0	0	0	C	21629893	C	C	21629893	3	2	16	1	0	0	0	0	1	0	0	0	13266	1406	49	5	1080	5	RECQL	12	21629893	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	753703	21629893	112222002	357	3745											
PPFIBP1	8496	broad.mit.edu	37	chr12	27844781	27844781	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggaattgggacaggcatcaGgaagtgcatctaagaaagga	15	7	14	5	0	2	1	1	0	1	1	2	5	2	5	0	5	1	2	0	5	4	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:27844781G>C	uc001ric.1	+	27	3180	c.2803G>C	c.(2803-2805)GGA>CGA	p.G935R	PPFIBP1_uc010sjr.1_Missense_Mutation_p.G766R|PPFIBP1_uc001rib.1_Missense_Mutation_p.G929R|PPFIBP1_uc001ria.2_Missense_Mutation_p.G904R|PPFIBP1_uc001rid.1_Missense_Mutation_p.G782R|PPFIBP1_uc001rif.1_Missense_Mutation_p.G442R	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	935					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					ACAGGCATCAGGAAGTGCATC	0.403													38	81					0	0	0	0	C	27844781	C	C	27844781	3	2	16	1	0	0	0	0	1	0	0	0	12368	1001	35	4	2929	4	PPFIBP1	12	27844781	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	6214888	27844781	106007114	358	3746											
PKP2	5318	broad.mit.edu	37	chr12	32975546	32975547	+	Frame_Shift_Del	DEL	CA	-	-																															aggagaggttatgaagaatgCacacacaattctccgtggcc																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:32975546_32975547delCA	uc001rlj.3	-	9	1940_1941	c.1825_1826delTG	c.(1825-1827)TGCfs	p.C609fs	PKP2_uc001rlk.3_Frame_Shift_Del_p.C565fs|PKP2_uc010skj.1_Frame_Shift_Del_p.C565fs	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	609	ARM 4.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					ATGAAGAATGCACACACAATTC	0.426													---	---	---								-	32975547	-	-	32975546	7	5	16	1	0	1	0	1	0	0	0	0	12040	710	25	0	843	0	PKP2	12	32975546	Frame_Shift_Del	DEL	CA	TCGA-BA-6869-01A-11D-1870-08	5130765	32975546	100876349	359	3747											
KIF21A	55605	broad.mit.edu	37	chr12	39720119	39720119	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctcatcagtactatcctcTacattttctacaaaaaaatg	14	14	2	11	0	4	0	2	0	2	0	6	0	6	0	2	0	3	1	2	0	7	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:39720119T>C	uc001rly.2	-	25	3494	c.3348A>G	c.(3346-3348)GTA>GTG	p.V1116V	KIF21A_uc001rlv.2_Silent_p.V121V|KIF21A_uc001rlw.2_Silent_p.V433V|KIF21A_uc001rlx.2_Silent_p.V1103V|KIF21A_uc001rlz.2_Silent_p.V1080V|KIF21A_uc010skl.1_Silent_p.V1096V	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1116					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TACTATCCTCTACATTTTCTA	0.358													11	35					0	0	0	0	C	39720119	C	C	39720119	2	2	16	1	0	0	0	0	0	0	0	1	8327	1509	53	5		5	KIF21A	12	39720119	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	6744573	39720119	94131776	360	3748											
LRRK2	120892	broad.mit.edu	37	chr12	40707845	40707845	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttgaaaaaatcattttatcGgagcgtaaaaatgtgccaat	16	12	7	6	2	1	1	1	1	0	0	2	2	1	2	1	1	2	1	1	1	8	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:40707845G>C	uc001rmg.3	+	32	4729	c.4608G>C	c.(4606-4608)TCG>TCC	p.S1536S	LRRK2_uc009zjw.2_Silent_p.S374S|LRRK2_uc001rmi.2_Silent_p.S369S	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1536					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCATTTTATCGGAGCGTAAAA	0.373													13	37					0	0	0	0	C	40707845	C	C	40707845	2	2	16	1	0	0	0	0	0	0	0	1	9083	1103	39	3		3	LRRK2	12	40707845	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	987726	40707845	93144050	361	3749											
NELL2	4753	broad.mit.edu	37	chr12	45173741	45173741	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacttctgtgtgagggcggtGactgcctgagcggtaatgca	7	10	15	9	2	1	3	0	3	1	0	1	3	1	3	1	3	3	2	1	3	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:45173741G>A	uc001rog.2	-	4	995	c.400C>T	c.(400-402)CAC>TAC	p.H134Y	NELL2_uc001rof.3_Missense_Mutation_p.H133Y|NELL2_uc001roh.2_Missense_Mutation_p.H134Y|NELL2_uc009zkd.2_Missense_Mutation_p.H133Y|NELL2_uc010skz.1_Missense_Mutation_p.H184Y|NELL2_uc010sla.1_Missense_Mutation_p.H157Y|NELL2_uc001roi.1_Missense_Mutation_p.H134Y|NELL2_uc010slb.1_Missense_Mutation_p.H133Y|NELL2_uc001roj.2_Missense_Mutation_p.H134Y	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	134	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TGAGGGCGGTGACTGCCTGAG	0.473													32	79					0	0	0	0	A	45173741	A	A	45173741	3	1	16	1	0	0	0	0	1	0	0	0	10388	1290	45	2	2118	2	NELL2	12	45173741	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4465896	45173741	88678154	362	3750											
KRT6C	286887	broad.mit.edu	37	chr12	52862855	52862855	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggcagcactttagtgcttGtagctcttcctgctggagga	7	12	13	9	0	1	0	0	0	1	0	2	3	2	2	1	3	4	6	1	3	2	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:52862855G>A	uc001sal.3	-	9	1734	c.1686C>T	c.(1684-1686)TAC>TAT	p.Y562Y		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	562	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		TTTAGTGCTTGTAGCTCTTCC	0.612													4	50					0	0	0	0	A	52862855	A	A	52862855	2	1	16	1	0	0	0	0	0	0	0	1	8521	1372	48	4		4	KRT6C	12	52862855	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	7689114	52862855	80989040	363	3751											
ANKRD52	283373	broad.mit.edu	37	chr12	56641850	56641850	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcgcttgcgctccttgatGagggcagaggcgccgtgggc	4	9	17	11	4	0	3	0	2	0	1	1	3	1	3	2	3	2	3	2	3	0	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:56641850G>A	uc001skm.3	-	18	2025	c.1935C>T	c.(1933-1935)CTC>CTT	p.L645L		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	645	ANK 18.						protein binding			ovary(2)	2						GCTCCTTGATGAGGGCAGAGG	0.632													11	19					0	0	0	0	A	56641850	A	A	56641850	2	1	16	1	0	0	0	0	0	0	0	1	678	1277	45	2		2	ANKRD52	12	56641850	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3778995	56641850	77210045	364	3752											
GNS	2799	broad.mit.edu	37	chr12	65130829	65130829	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggtcctcgaaccaacagTggaactttgatatcaaactc	13	9	7	12	1	1	1	1	1	0	0	4	3	2	2	3	2	4	0	3	2	5	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:65130829T>C	uc001ssg.3	-	9	1223	c.1053A>G	c.(1051-1053)CCA>CCG	p.P351P	GNS_uc001ssf.2_Silent_p.P295P|GNS_uc010ssq.1_Silent_p.P383P|GNS_uc010ssr.1_Silent_p.P331P	NM_002076	NP_002067	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase precursor	351						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		GAACCAACAGTGGAACTTTGA	0.453													16	51					0	0	0	0	C	65130829	C	C	65130829	2	2	16	1	0	0	0	0	0	0	0	1	6587	1683	59	5		5	GNS	12	65130829	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	8488979	65130829	68721066	365	3753											
PPFIA2	8499	broad.mit.edu	37	chr12	81768458	81768458	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagttcagcctctacttcAggcaaggtttcagcctttct	7	13	8	13	0	5	0	3	0	2	0	5	0	5	0	3	2	3	3	3	2	2	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:81768458A>T	uc001szo.1	-	11	1382	c.1221T>A	c.(1219-1221)CCT>CCA	p.P407P	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	333										ovary(3)|lung(2)|pancreas(1)	6						CCTCTACTTCAGGCAAGGTTT	0.433													39	61					0	0	0	0	T	81768458	T	T	81768458	2	4	16	1	0	0	0	0	0	0	0	1	12365	175	7	5		5	PPFIA2	12	81768458	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	16637629	81768458	52083437	366	3754											
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100492321	100492321	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagcaaagccgtattcacTggaaaaacaaagcaaaacaa	20	6	6	9	1	2	0	2	0	0	0	2	1	2	1	1	1	5	3	1	1	8	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:100492321T>C	uc001tgq.2	-	5	568	c.339_splice	c.e5-1	p.S113_splice	UHRF1BP1L_uc001tgr.2_Splice_Site_p.S113_splice	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a											ovary(2)	2						CCGTATTCACTGGAAAAACAA	0.259													16	23					0	0	0	0	C	100492321	C	C	100492321	5	2	16	1	0	0	0	0	0	0	1	0	17037	1594	55	5	4149	5	UHRF1BP1L	12	100492321	Splice_Site	SNP	T	TCGA-BA-6869-01A-11D-1870-08	18723863	100492321	33359574	367	3755											
NT5DC3	51559	broad.mit.edu	37	chr12	104187036	104187036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaacgatataactcatccCtttgtccctagggcaacaag	12	9	6	14	1	1	0	1	0	0	0	3	1	3	0	3	1	3	1	3	1	6	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:104187036C>T	uc010swe.1	-	9	966	c.925G>A	c.(925-927)GGG>AGG	p.G309R		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	309							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						TAACTCATCCCTTTGTCCCTA	0.418													63	167					0	0	0	0	T	104187036	T	T	104187036	3	4	16	1	0	0	0	0	1	0	0	0	10746	681	24	4	745	4	NT5DC3	12	104187036	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3694715	104187036	29664859	368	3756											
SLC41A2	84102	broad.mit.edu	37	chr12	105321903	105321903	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcatcaccatcactagataTatcttcatcttgtaacatgg	12	15	4	10	0	6	1	4	0	2	1	6	1	6	1	1	1	1	1	1	1	4	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:105321903T>G	uc001tla.2	-	1	570	c.403A>C	c.(403-405)ATA>CTA	p.I135L		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	135	Extracellular.					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TCACTAGATATATCTTCATCT	0.393													34	75					0	0	0	0	G	105321903	G	G	105321903	3	3	16	1	0	0	0	0	1	0	0	0	14694	1406	49	5	1358	5	SLC41A2	12	105321903	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	1134867	105321903	28529992	369	3757											
NUAK1	9891	broad.mit.edu	37	chr12	106461453	106461453	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaaagtcattctctttcttGgatttcttcagcgaccgctg	7	15	8	11	2	5	0	2	0	3	0	6	2	5	1	1	1	1	2	1	1	1	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:106461453G>T	uc001tlj.1	-	7	2493	c.1113C>A	c.(1111-1113)TCC>TCA	p.S371S		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	371							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						TCTCTTTCTTGGATTTCTTCA	0.547													32	68					1.45844e-13	1.87346e-13	1	0	T	106461453	T	T	106461453	2	4	16	1	0	0	0	0	0	0	0	1	10766	1335	47	4		4	NUAK1	12	106461453	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1139550	106461453	27390442	370	3758											
WSCD2	9671	broad.mit.edu	37	chr12	108603974	108603974	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tccaggcgacgaacgtgagcGaggcagagtgcgacatggag	11	4	17	9	5	0	2	0	1	0	1	1	7	1	3	1	3	3	1	1	3	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:108603974G>C	uc001tms.2	+	4	1318	c.574G>C	c.(574-576)GAG>CAG	p.E192Q	WSCD2_uc001tmt.2_Missense_Mutation_p.E192Q	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	192	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GAACGTGAGCGAGGCAGAGTG	0.677													8	26					0	0	0	0	C	108603974	C	C	108603974	3	2	16	1	0	0	0	0	1	0	0	0	17475	1059	37	3	584	3	WSCD2	12	108603974	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2142521	108603974	25247921	371	3759											
C12orf51	283450	broad.mit.edu	37	chr12	112673511	112673511	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taaggactagctttggagacGggcgttggtcaagcagcagg	10	8	16	7	2	1	1	1	0	0	1	1	3	1	2	0	5	3	4	0	5	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:112673511G>A	uc009zwc.2	-	29	4274	c.4256C>T	c.(4255-4257)CCG>CTG	p.P1419L		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CTTTGGAGACGGGCGTTGGTC	0.562													11	21					0	0	0	0	A	112673511	A	A	112673511	3	1	16	1	0	0	0	0	1	0	0	0	1702	1116	39	1	7898	1	C12orf51	12	112673511	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4069537	112673511	21178384	372	3760											
C12orf51	283450	broad.mit.edu	37	chr12	112684766	112684766	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgactgggctgcgatggtGacatgcagcaacagctcggc	8	6	14	13	3	0	1	0	1	0	0	1	3	0	1	1	3	5	4	1	3	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:112684766G>C	uc009zwc.2	-	22	3204	c.3186C>G	c.(3184-3186)GTC>GTG	p.V1062V		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CTGCGATGGTGACATGCAGCA	0.493													22	24					0	0	0	0	C	112684766	C	C	112684766	2	2	16	1	0	0	0	0	0	0	0	1	1702	1277	45	2		2	C12orf51	12	112684766	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	11255	112684766	21167129	373	3761											
RASAL1	8437	broad.mit.edu	37	chr12	113543582	113543582	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccagacgtagcgcttcttGaaggcaaagcgcgtggccag	10	6	14	11	4	1	2	0	1	1	1	1	2	1	2	2	2	3	3	2	2	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:113543582G>A	uc001tum.1	-	17	2057	c.1764C>T	c.(1762-1764)TTC>TTT	p.F588F	RASAL1_uc010syp.1_Silent_p.F589F|RASAL1_uc001tul.2_Silent_p.F588F|RASAL1_uc001tun.1_Silent_p.F590F|RASAL1_uc010syq.1_Silent_p.F589F|RASAL1_uc001tuo.3_Silent_p.F589F	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	588	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						AGCGCTTCTTGAAGGCAAAGC	0.637													31	54					0	0	0	0	A	113543582	A	A	113543582	2	1	16	1	0	0	0	0	0	0	0	1	13128	1281	45	2		2	RASAL1	12	113543582	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	858816	113543582	20308313	374	3762											
IQCD	115811	broad.mit.edu	37	chr12	113645397	113645397	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtagtttttcaaacaggaaaCcacggagctctatcaggctg	12	10	10	9	1	3	0	2	0	1	0	3	2	3	2	1	3	3	4	1	3	4	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:113645397C>T	uc001tuv.1	-	2	997	c.575G>A	c.(574-576)GGT>GAT	p.G192D	IQCD_uc001tuu.2_Missense_Mutation_p.G192D	NM_138451	NP_612460	Q96DY2	IQCD_HUMAN	IQ motif containing D	192										ovary(1)	1						AAACAGGAAACCACGGAGCTC	0.473													22	66					0	0	0	0	T	113645397	T	T	113645397	3	4	16	1	0	0	0	0	1	0	0	0	7844	507	18	4	476	4	IQCD	12	113645397	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	101815	113645397	20206498	375	3763											
SRRM4	84530	broad.mit.edu	37	chr12	119563220	119563220	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgaaagtctcaccgccacCgccatcaccgctgcccctcg	7	5	7	22	5	2	0	2	0	1	0	4	1	2	0	8	0	1	1	8	0	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:119563220C>A	uc001txa.1	+	7	842	c.550C>A	c.(550-552)CGC>AGC	p.R184S		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	184	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						TCACCGCCACCGCCATCACCG	0.478													17	27					6.94344e-10	8.25742e-10	1	0	A	119563220	A	A	119563220	3	1	16	1	0	0	0	0	1	0	0	0	15237	652	23	3	576	3	SRRM4	12	119563220	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	5917823	119563220	14288675	376	3764											
COQ5	84274	broad.mit.edu	37	chr12	120947835	120947835	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catacctgatcaatgtgtgtGacattccggatcccaaaggc	11	10	9	11	1	1	2	1	2	0	0	3	3	3	3	3	2	1	0	3	2	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr12:120947835G>C	uc001tyn.2	-	4	686	c.666C>G	c.(664-666)GTC>GTG	p.V222V	COQ5_uc001tyo.2_Silent_p.V141V|COQ5_uc010szj.1_Silent_p.V148V	NM_032314	NP_115690	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase	222					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAATGTGTGTGACATTCCGGA	0.438													15	37					0	0	0	0	C	120947835	C	C	120947835	2	2	16	1	0	0	0	0	0	0	0	1	3763	1277	45	2		2	COQ5	12	120947835	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1384615	120947835	12904060	377	3765											
TUBA3C	7278	broad.mit.edu	37	chr13	19751082	19751082	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cataccttaaatccagttggGcaccaatctacaaactggat	14	10	6	11	0	1	0	0	0	1	0	2	1	2	1	3	2	3	2	3	2	6	4	rs148928584		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:19751082G>T	uc009zzj.2	-	4	1090	c.1041C>A	c.(1039-1041)TGC>TGA	p.C347*		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	347					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		ATCCAGTTGGGCACCAATCTA	0.527													13	19					1.15088e-07	1.29651e-07	1	0	T	19751082	T	T	19751082	4	4	16	1	0	0	0	0	0	1	0	0	16814	1195	42	4	319	4	TUBA3C	13	19751082	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08		19751082	95418796	378	3766											
BRCA2	675	broad.mit.edu	37	chr13	32907114	32907114	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agtggcttcttcatttcaggGtatcaaaaagtctatattca	12	15	7	7	0	6	0	4	0	2	0	6	0	6	0	0	2	0	2	0	2	5	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:32907114G>T	uc001uub.1	+	10	1726	c.1499G>T	c.(1498-1500)GGT>GTT	p.G500V	BRCA2_uc001uua.1_Missense_Mutation_p.G377V	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	500					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TCATTTCAGGGTATCAAAAAG	0.363			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			25	33					4.26978e-12	5.34556e-12	1	0	T	32907114	T	T	32907114	3	4	16	1	0	0	0	0	1	0	0	0	1504	1261	44	4	1533	4	BRCA2	13	32907114	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	13156032	32907114	82262764	379	3767											
FREM2	341640	broad.mit.edu	37	chr13	39343823	39343823	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagggccacatggcgagtgcGgatcctgagtgatggggagc	8	6	18	9	2	0	2	0	2	0	0	1	5	1	4	2	5	2	0	2	5	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:39343823G>T	uc001uwv.2	+	4	5828	c.5519G>T	c.(5518-5520)CGG>CTG	p.R1840L	FREM2_uc001uww.2_5'UTR	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1840	Calx-beta 1.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGGCGAGTGCGGATCCTGAGT	0.537													19	21					2.39187e-15	3.17264e-15	1	0	T	39343823	T	T	39343823	3	4	16	1	0	0	0	0	1	0	0	0	6079	1116	39	3	5533	3	FREM2	13	39343823	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	6436709	39343823	75826055	380	3768											
FREM2	341640	broad.mit.edu	37	chr13	39425200	39425200	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccctttggggctgcagttGgtgaacaaaatgaaactctc	10	11	10	10	0	1	2	0	2	1	0	3	2	2	2	1	3	3	3	1	3	4	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:39425200G>C	uc001uwv.2	+	10	7006	c.6697G>C	c.(6697-6699)GGT>CGT	p.G2233R	FREM2_uc001uww.2_Missense_Mutation_p.G319R	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2233	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGCTGCAGTTGGTGAACAAAA	0.438													16	24					0	0	0	0	C	39425200	C	C	39425200	3	2	16	1	0	0	0	0	1	0	0	0	6079	1348	47	4	6735	4	FREM2	13	39425200	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	81377	39425200	75744678	381	3769											
DIAPH3	81624	broad.mit.edu	37	chr13	60590252	60590252	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atgtctaataataatccaagCccttcatgtccaaagctttc	13	13	4	11	0	2	0	1	0	1	0	5	0	4	0	3	0	2	1	3	0	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:60590252C>T	uc001vht.2	-	6	873	c.654G>A	c.(652-654)GGG>GGA	p.G218G	DIAPH3_uc001vhu.2_5'Flank|DIAPH3_uc001vhw.1_Silent_p.G207G|DIAPH3_uc010aed.1_Silent_p.G172G|DIAPH3_uc010aee.1_Silent_p.G148G|uc001vhx.2_Intron|uc001vhy.2_Intron	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	218	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		ATAATCCAAGCCCTTCATGTC	0.313													7	15					0	0	0	0	T	60590252	T	T	60590252	2	4	16	1	0	0	0	0	0	0	0	1	4542	726	26	4		4	DIAPH3	13	60590252	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	21165052	60590252	54579626	382	3770											
MYO16	23026	broad.mit.edu	37	chr13	109318423	109318423	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgaaaaggctgaagcatgCgaagaatccgaaagttcact	15	7	10	9	2	1	3	1	2	0	1	2	5	2	3	2	1	2	3	2	1	6	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr13:109318423C>A	uc001vqt.1	+	2	278	c.152C>A	c.(151-153)GCG>GAG	p.A51E	MYO16_uc010agk.1_Missense_Mutation_p.A73E	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	51					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity	p.A51A(1)		ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CTGAAGCATGCGAAGAATCCG	0.483													12	12					3.07112e-06	3.38245e-06	1	0	A	109318423	A	A	109318423	3	1	16	1	0	0	0	0	1	0	0	0	10117	768	27	3	154	3	MYO16	13	109318423	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	48728171	109318423	5851455	383	3771											
POTEG	404785	broad.mit.edu	37	chr14	19553682	19553682	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctggagaccacgacgactCtgctatgaagacactcagga	12	8	10	11	2	3	3	1	1	2	2	3	7	3	4	1	2	1	1	1	2	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:19553682C>T	uc001vuz.1	+	1	318	c.266C>T	c.(265-267)TCT>TTT	p.S89F	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	89										ovary(1)	1						CACGACGACTCTGCTATGAAG	0.617													23	531					0	0	0	0	T	19553682	T	T	19553682	3	4	16	1	0	0	0	0	1	0	0	0	12321	913	32	2	268	2	POTEG	14	19553682	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08		19553682	87795858	384	3772											
POTEG	404785	broad.mit.edu	37	chr14	19553819	19553819	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatggagccgaggtaccacGtccgtcgagaagatctggac	10	7	13	11	4	2	2	1	0	1	2	4	6	3	4	3	3	2	1	3	3	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:19553819G>A	uc001vuz.1	+	1	455	c.403G>A	c.(403-405)GTC>ATC	p.V135I	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	135										ovary(1)	1						GAGGTACCACGTCCGTCGAGA	0.582													11	285					0	0	0	0	A	19553819	A	A	19553819	3	1	16	1	0	0	0	0	1	0	0	0	12321	1145	40	1	405	1	POTEG	14	19553819	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	137	19553819	87795721	385	3773											
FOXG1	2290	broad.mit.edu	37	chr14	29236541	29236541	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatccccaagtcctcgttcaGcatcaacagcctggtgcccg	8	8	9	16	2	2	0	2	0	0	0	5	1	4	0	5	1	4	2	5	1	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:29236541G>T	uc001wqe.2	+	1	255	c.56G>T	c.(55-57)AGC>ATC	p.S19I		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	19					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TCCTCGTTCAGCATCAACAGC	0.393													7	18					1.12685e-05	1.21397e-05	1	0	T	29236541	T	T	29236541	3	4	16	1	0	0	0	0	1	0	0	0	6041	971	34	4	58	4	FOXG1	14	29236541	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	9682722	29236541	78112999	386	3774											
PRKD1	5587	broad.mit.edu	37	chr14	30194823	30194823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaggatgttttcagaggtagGgtcatggcgaaaaagcagga	14	8	15	4	1	2	1	2	0	0	1	2	4	2	3	0	5	1	3	0	5	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:30194823G>A	uc001wqh.2	-	2	503	c.322C>T	c.(322-324)CCT>TCT	p.P108S		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	108					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TCAGAGGTAGGGTCATGGCGA	0.413													16	45					0	0	0	0	A	30194823	A	A	30194823	3	1	16	1	0	0	0	0	1	0	0	0	12580	1232	43	4	2484	4	PRKD1	14	30194823	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	958282	30194823	77154717	387	3775											
CLEC14A	161198	broad.mit.edu	37	chr14	38724494	38724494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggaggtacctcccggggcagGgacacaacacatcgcccgag	10	3	14	14	3	0	0	0	0	0	0	2	3	1	2	3	5	2	2	3	5	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:38724494G>A	uc001wum.1	-	1	1081	c.734C>T	c.(733-735)CCC>CTC	p.P245L		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	245	Extracellular (Potential).|EGF-like.					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CCCGGGGCAGGGACACAACAC	0.617													46	120					0	0	0	0	A	38724494	A	A	38724494	3	1	16	1	0	0	0	0	1	0	0	0	3514	1232	43	4	742	4	CLEC14A	14	38724494	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	8529671	38724494	68625046	388	3776											
PLEKHG3	26030	broad.mit.edu	37	chr14	65208417	65208417	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagctattatgaaaatgcaGaacaccatgatgcaggcttc	15	9	9	8	0	0	4	0	2	0	2	1	4	0	4	1	1	4	4	1	1	5	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:65208417G>C	uc001xho.1	+	16	2451	c.2182G>C	c.(2182-2184)GAA>CAA	p.E728Q	PLEKHG3_uc001xhn.1_Missense_Mutation_p.E672Q|PLEKHG3_uc001xhp.2_Missense_Mutation_p.E849Q|PLEKHG3_uc010aqh.1_Missense_Mutation_p.E270Q|PLEKHG3_uc001xhq.1_Missense_Mutation_p.E233Q	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	728				YYENAEHHDAGFSV -> WWPHCTPASCSSPT (in Ref. 2; AAH04298).	regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TGAAAATGCAGAACACCATGA	0.527													22	84					0	0	0	0	C	65208417	C	C	65208417	3	2	16	1	0	0	0	0	1	0	0	0	12125	943	33	2	2064	2	PLEKHG3	14	65208417	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	26483923	65208417	42141123	389	3777											
ZFYVE26	23503	broad.mit.edu	37	chr14	68274302	68274302	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cacaggagatgcaactcaacCccaagtggttctgcggggca	11	6	12	12	1	2	1	1	0	1	1	2	2	2	1	2	4	4	3	2	4	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:68274302C>A	uc001xka.2	-	5	838	c.699G>T	c.(697-699)GGG>GGT	p.G233G	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Silent_p.G233G|ZFYVE26_uc010tta.1_Silent_p.G233G	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	233					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCAACTCAACCCCAAGTGGTT	0.637													16	31					2.31682e-05	2.46692e-05	1	0	A	68274302	A	A	68274302	2	1	16	1	0	0	0	0	0	0	0	1	17735	610	22	4		4	ZFYVE26	14	68274302	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3065885	68274302	39075238	390	3778											
CYP46A1	10858	broad.mit.edu	37	chr14	100172989	100172989	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctgtttctccagctcctTggttagcttaatggaaacat	8	15	9	9	0	1	0	0	0	1	0	3	1	2	1	2	2	4	5	2	2	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:100172989T>A	uc001ygo.2	+	6	449	c.449T>A	c.(448-450)TTG>TAG	p.L150*	CYP46A1_uc001ygn.1_Nonsense_Mutation_p.L112*|CYP46A1_uc001ygp.2_5'UTR	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	150					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				TCCAGCTCCTTGGTTAGCTTA	0.547													22	44					0	0	0	0	A	100172989	A	A	100172989	4	1	16	1	0	0	0	0	0	1	0	0	4199	1821	63	5	471	5	CYP46A1	14	100172989	Nonsense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	31898687	100172989	7176551	391	3779											
AHNAK2	113146	broad.mit.edu	37	chr14	105411241	105411241	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgaggtcagtggccttgAggtccccctgcatggaggag	6	9	16	10	0	1	2	1	2	0	0	2	4	2	4	3	5	2	2	3	5	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr14:105411241A>C	uc010axc.1	-	7	10667	c.10547T>G	c.(10546-10548)CTC>CGC	p.L3516R	AHNAK2_uc001ypx.2_Missense_Mutation_p.L3416R	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3516						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGTGGCCTTGAGGTCCCCCTG	0.667													49	125					0	0	0	0	C	105411241	C	C	105411241	3	2	16	1	0	0	0	0	1	0	0	0	415	304	11	5	6844	5	AHNAK2	14	105411241	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	5238252	105411241	1938299	392	3780											
OR4M2	390538	broad.mit.edu	37	chr15	22369024	22369024	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctggtggctctctcctggaGggggggcttcattcattcta	4	13	13	11	0	4	0	2	0	2	0	6	1	5	1	2	6	0	2	2	6	1	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:22369024G>T	uc010tzu.1	+	1	449	c.449G>T	c.(448-450)AGG>ATG	p.R150M	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTCTCCTGGAGGGGGGGCTTC	0.502													49	313					1.74971e-23	2.50349e-23	1	0	T	22369024	T	T	22369024	3	4	16	1	0	0	0	0	1	0	0	0	11130	1000	35	4	451	4	OR4M2	15	22369024	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08		22369024	80162368	393	3781											
OR4N4	283694	broad.mit.edu	37	chr15	22382647	22382647	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accctgggctcacagcccccCtctatttatttctgggcaac	7	11	7	16	0	3	0	1	0	2	0	3	0	3	0	4	2	2	2	4	2	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:22382647C>T	uc001yuc.1	+	7	1156	c.175C>T	c.(175-177)CTC>TTC	p.L59F	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.L59F	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CACAGCCCCCCTCTATTTATT	0.453													48	141					0	0	0	0	T	22382647	T	T	22382647	3	4	16	1	0	0	0	0	1	0	0	0	11132	681	24	4	177	4	OR4N4	15	22382647	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	13623	22382647	80148745	394	3782			1	5		3	3	770	N	G_C	8.840025e-05
OR4N4	283694	broad.mit.edu	37	chr15	22382715	22382715	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcattgtggctcccaggatGttggtggacttcctctctga	5	15	11	10	0	2	1	1	1	1	0	5	3	4	3	2	4	0	2	2	4	0	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:22382715G>A	uc001yuc.1	+	7	1224	c.243G>A	c.(241-243)ATG>ATA	p.M81I	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.M81I	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTCCCAGGATGTTGGTGGACT	0.517													28	121					0	0	0	0	A	22382715	A	A	22382715	3	1	16	1	0	0	0	0	1	0	0	0	11132	1377	48	4	245	4	OR4N4	15	22382715	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	68	22382715	80148677	395	3783			1	5		3	3	770	N	G_C	8.840025e-05
OR4N4	283694	broad.mit.edu	37	chr15	22383416	22383416	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaagtggattttataataaGaaactgagaaggaggaattc	17	11	10	3	0	1	2	1	1	0	2	2	6	1	5	0	3	1	0	0	3	7	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:22383416G>T	uc001yuc.1	+	7	1925	c.944G>T	c.(943-945)AGA>ATA	p.R315I	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.R315I	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	315	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTTATAATAAGAAACTGAGAA	0.254													11	21					6.40141e-05	6.77113e-05	1	0	T	22383416	T	T	22383416	3	4	16	1	0	0	0	0	1	0	0	0	11132	942	33	2	946	2	OR4N4	15	22383416	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	701	22383416	80147976	396	3784			1	5		3	3	770	N	G_C	8.840025e-05
MAGEL2	54551	broad.mit.edu	37	chr15	23890799	23890799	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgctgctaccgggggtccGggctgggcctgcaagactgc	4	6	17	14	3	0	1	0	0	0	1	1	1	1	1	4	4	4	4	4	4	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:23890799G>T	uc001ywj.3	-	1	377	c.282C>A	c.(280-282)CCC>CCA	p.P94P		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		CCGGGGGTCCGGGCTGGGCCT	0.652													3	8					0.004672	0.0047916	1	0	T	23890799	T	T	23890799	2	4	16	1	0	0	0	0	0	0	0	1	9242	1103	39	3		3	MAGEL2	15	23890799	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1507383	23890799	78640593	397	3785											
GABRA5	2558	broad.mit.edu	37	chr15	27160007	27160007	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttcccgatggatgcgcaCgcttgccctctgaaatttgg	7	11	11	12	3	1	1	0	1	1	0	2	4	2	2	2	2	2	2	2	2	1	3	rs140643363	by1000genomes	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:27160007C>G	uc001zbd.1	+	8	894	c.555C>G	c.(553-555)CAC>CAG	p.H185Q	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	185	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGGATGCGCACGCTTGCCCTC	0.433													17	18					0	0	0	0	G	27160007	G	G	27160007	3	3	16	1	0	0	0	0	1	0	0	0	6198	535	19	3	573	3	GABRA5	15	27160007	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3269208	27160007	75371385	398	3786											
C15orf55	256646	broad.mit.edu	37	chr15	34640812	34640812	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttccgtcagtggcagcgttAcaaagccttggcccggaggc	7	8	13	13	3	1	0	1	0	0	0	2	1	2	1	3	4	3	2	3	4	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:34640812A>T	uc001zif.2	+	2	814	c.659A>T	c.(658-660)TAC>TTC	p.Y220F	C15orf55_uc010ucc.1_Missense_Mutation_p.Y248F|C15orf55_uc010ucd.1_Missense_Mutation_p.Y238F	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	220						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		TGGCAGCGTTACAAAGCCTTG	0.512			T	BRD3|BRD4	lethal midline carcinoma								33	33					0	0	0	0	T	34640812	T	T	34640812	3	4	16	1	0	0	0	0	1	0	0	0	1809	391	14	5	665	5	C15orf55	15	34640812	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	7480805	34640812	67890580	399	3787											
MAP1A	4130	broad.mit.edu	37	chr15	43821049	43821049	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacccacctctgcccccaTccatagatgatagggacctc	10	8	7	16	0	1	3	0	2	1	1	3	4	2	4	6	1	2	0	6	1	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:43821049T>A	uc001zrt.2	+	4	7845	c.7378T>A	c.(7378-7380)TCC>ACC	p.S2460T		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2460						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TCTGCCCCCATCCATAGATGA	0.662													25	16					0	0	0	0	A	43821049	A	A	43821049	3	1	16	1	0	0	0	0	1	0	0	0	9280	1435	50	5	7380	5	MAP1A	15	43821049	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	9180237	43821049	58710343	400	3788											
MYO5C	55930	broad.mit.edu	37	chr15	52532055	52532055	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgtatttctgtaggatcaCagccttatgttcctccagca	8	14	8	11	1	2	0	1	0	1	0	4	1	4	1	3	1	3	4	3	1	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:52532055C>A	uc010bff.2	-	21	2715	c.2578G>T	c.(2578-2580)GTG>TTG	p.V860L	MYO5C_uc010uga.1_RNA|MYO5C_uc010ugb.1_Intron	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	860	IQ 5.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		TGTAGGATCACAGCCTTATGT	0.463													15	23					1.05317e-09	1.24554e-09	1	0	A	52532055	A	A	52532055	3	1	16	1	0	0	0	0	1	0	0	0	10133	478	17	4	2734	4	MYO5C	15	52532055	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	8711006	52532055	49999337	401	3789											
DENND4A	10260	broad.mit.edu	37	chr15	66007893	66007893	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acattcttcaatgaagcgaaTaaacatttgtgttttggtca	13	15	7	6	1	3	1	2	1	1	0	3	2	3	1	0	1	2	1	0	1	5	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:66007893T>A	uc002aph.2	-	14	2254	c.1876A>T	c.(1876-1878)ATT>TTT	p.I626F	DENND4A_uc002api.2_Missense_Mutation_p.I626F|DENND4A_uc002apj.3_Missense_Mutation_p.I626F|DENND4A_uc010ujj.1_Missense_Mutation_p.I626F	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	626	dDENN.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						ATGAAGCGAATAAACATTTGT	0.328													7	21					0	0	0	0	A	66007893	A	A	66007893	3	1	16	1	0	0	0	0	1	0	0	0	4455	1406	49	5	3924	5	DENND4A	15	66007893	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	13475838	66007893	36523499	402	3790											
IQCH	64799	broad.mit.edu	37	chr15	67757467	67757467	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctcctgttttaatcaggtGtgggcaaccggccttaacct	7	12	11	11	1	1	0	1	0	0	0	2	0	2	0	4	4	2	3	4	4	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:67757467G>T	uc002aqo.1	+	17	2555	c.2508G>T	c.(2506-2508)GTG>GTT	p.V836V	IQCH_uc002aqq.1_Silent_p.V493V|IQCH_uc002aqp.1_Silent_p.V497V|uc002aqr.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	836										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		TTAATCAGGTGTGGGCAACCG	0.517													21	43					9.57634e-11	1.16479e-10	1	0	T	67757467	T	T	67757467	2	4	16	1	0	0	0	0	0	0	0	1	7850	1364	48	4		4	IQCH	15	67757467	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1749574	67757467	34773925	403	3791											
TBC1D21	161514	broad.mit.edu	37	chr15	74178505	74178505	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctggaccccgtgtttgcTgagcacctaagtgagtggtt	6	13	12	10	1	0	2	0	2	0	0	1	3	1	3	4	2	2	4	4	2	1	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:74178505T>A	uc002avz.2	+	7	749	c.666T>A	c.(664-666)GCT>GCA	p.A222A	TBC1D21_uc010ulc.1_Silent_p.A186A	NM_153356	NP_699187	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	222	Rab-GAP TBC.					intracellular	Rab GTPase activator activity	p.A222P(1)		ovary(2)	2						CCGTGTTTGCTGAGCACCTAA	0.592													15	35					0	0	0	0	A	74178505	A	A	74178505	2	1	16	1	0	0	0	0	0	0	0	1	15676	1567	55	5		5	TBC1D21	15	74178505	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	6421038	74178505	28352887	404	3792											
ACSBG1	23205	broad.mit.edu	37	chr15	78474423	78474423	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggtagctgactaccaccTcctgctggacttctgccggc	6	9	11	15	1	1	1	0	1	1	0	2	2	2	2	4	3	4	4	4	3	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:78474423T>C	uc002bdh.2	-	8	1015	c.959A>G	c.(958-960)GAG>GGG	p.E320G	ACSBG1_uc010umw.1_Missense_Mutation_p.E316G|ACSBG1_uc010umx.1_Missense_Mutation_p.E78G|ACSBG1_uc010umy.1_Missense_Mutation_p.E213G	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	320					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						GACTACCACCTCCTGCTGGAC	0.627													21	32					0	0	0	0	C	78474423	C	C	78474423	3	2	16	1	0	0	0	0	1	0	0	0	173	1551	54	5	1243	5	ACSBG1	15	78474423	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	4295918	78474423	24056969	405	3793											
IL16	3603	broad.mit.edu	37	chr15	81517813	81517813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccatctccaggtccctgatgCtctgtaatgctaagaccagt	9	11	8	13	0	2	2	0	1	2	1	4	2	3	2	4	1	2	3	4	1	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:81517813C>T	uc002bgh.3	+	2	449	c.73C>T	c.(73-75)CTC>TTC	p.L25F	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.L25F|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.L67F|IL16_uc002bgg.2_Missense_Mutation_p.L25F	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	25					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GTCCCTGATGCTCTGTAATGC	0.498													19	50					0	0	0	0	T	81517813	T	T	81517813	3	4	16	1	0	0	0	0	1	0	0	0	7672	797	28	4	75	4	IL16	15	81517813	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3043390	81517813	21013579	406	3794											
TMC3	342125	broad.mit.edu	37	chr15	81625263	81625263	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggggagggaggctggcGggggacccgggatgcatatt	6	7	21	7	2	0	0	0	0	0	0	0	4	0	4	1	8	1	2	1	8	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:81625263G>T	uc002bgo.1	-	22	2800	c.2800C>A	c.(2800-2802)CGC>AGC	p.R934S	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	934	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						GGAGGCTGGCGGGGGACCCGG	0.552													13	44					9.05144e-12	1.1266e-11	1	0	T	81625263	T	T	81625263	3	4	16	1	0	0	0	0	1	0	0	0	16052	1116	39	3	506	3	TMC3	15	81625263	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	107450	81625263	20906129	407	3795											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84657464	84657464	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ataattttggatggaactggGaagatacagatacagaatcc	16	10	10	5	0	0	3	0	0	0	3	1	6	1	6	1	3	3	0	1	3	6	5	rs141705388		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:84657464G>T	uc002bjz.3	+	22	3962	c.3738G>T	c.(3736-3738)GGG>GGT	p.G1246G	ADAMTSL3_uc010bmt.1_Silent_p.G1246G|ADAMTSL3_uc010bmu.1_Silent_p.G1246G	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1246	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			ATGGAACTGGGAAGATACAGA	0.373													8	39					5.18039e-06	5.65695e-06	1	0	T	84657464	T	T	84657464	2	4	16	1	0	0	0	0	0	0	0	1	276	1161	41	2		2	ADAMTSL3	15	84657464	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3032201	84657464	17873928	408	3796											
ZNF592	9640	broad.mit.edu	37	chr15	85326315	85326315	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagtcagagccattacccAccttcaaccagttcagtcca	12	8	5	16	0	3	1	3	0	0	1	4	1	4	1	6	0	3	1	6	0	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:85326315A>C	uc002bld.2	+	4	745	c.409A>C	c.(409-411)ACC>CCC	p.T137P	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	137					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCATTACCCACCTTCAACCA	0.478													49	91					0	0	0	0	C	85326315	C	C	85326315	3	2	16	1	0	0	0	0	1	0	0	0	18089	159	6	5	411	5	ZNF592	15	85326315	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	668851	85326315	17205077	409	3797											
AGBL1	123624	broad.mit.edu	37	chr15	86790944	86790944	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaccgaggctacgtcaccaGcctgctcgggctgcaccagg	8	5	13	15	3	1	0	1	0	0	0	2	2	1	0	4	3	5	4	4	3	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:86790944G>C	uc002blz.1	+	6	511	c.431G>C	c.(430-432)AGC>ACC	p.S144T		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	144					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TACGTCACCAGCCTGCTCGGG	0.612													12	11					0	0	0	0	C	86790944	C	C	86790944	3	2	16	1	0	0	0	0	1	0	0	0	375	971	34	4	449	4	AGBL1	15	86790944	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1464629	86790944	15740448	410	3798											
PEX11A	8800	broad.mit.edu	37	chr15	90227164	90227164	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctgtatagcatgtaccacaTtgcctagtctgaaccctgca	10	11	7	13	0	1	1	0	1	1	0	1	1	1	1	4	0	5	4	4	0	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:90227164T>C	uc002boi.2	-	3	283	c.188A>G	c.(187-189)AAT>AGT	p.N63S	PEX11A_uc010upy.1_RNA	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	63	Cytoplasmic (Potential).				cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			ATGTACCACATTGCCTAGTCT	0.448													23	48					0	0	0	0	C	90227164	C	C	90227164	3	2	16	1	0	0	0	0	1	0	0	0	11792	1493	52	5	559	5	PEX11A	15	90227164	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	3436220	90227164	12304228	411	3799											
NR2F2	7026	broad.mit.edu	37	chr15	96875646	96875646	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcaagagcttcttcaaGcgcagcgtgcggaggaacct	9	7	14	11	3	2	1	1	0	1	1	2	3	2	3	1	3	6	4	1	3	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr15:96875646G>C	uc010uri.1	+	1	1536	c.312G>C	c.(310-312)AAG>AAC	p.K104N	NR2F2_uc002btp.2_Intron|NR2F2_uc010urj.1_5'Flank|MIR1469_hsa-mir-1469|MI0007074_5'Flank|NR2F2_uc010urk.1_5'Flank	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	104	Nuclear receptor.				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			GCTTCTTCAAGCGCAGCGTGC	0.612													8	28					0	0	0	0	C	96875646	C	C	96875646	3	2	16	1	0	0	0	0	1	0	0	0	10682	962	34	4	361	4	NR2F2	15	96875646	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	6648482	96875646	5655746	412	3800											
CREBBP	1387	broad.mit.edu	37	chr16	3781465	3781465	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagcgtgcaggtggatcaCgaagaagacctgcaggagag	12	4	15	10	2	1	3	1	0	0	3	1	6	1	4	2	3	3	2	2	3	2	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:3781465C>A	uc002cvv.2	-	30	5104	c.4900G>T	c.(4900-4902)GTG>TTG	p.V1634L	CREBBP_uc002cvw.2_Missense_Mutation_p.V1596L	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1634	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AGGTGGATCACGAAGAAGACC	0.642			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				6	1					0.00198382	0.00204771	1	0	A	3781465	A	A	3781465	3	1	16	1	0	0	0	0	1	0	0	0	3876	536	19	3	2436	3	CREBBP	16	3781465	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08		3781465	86573288	413	3801											
A2BP1	54715	broad.mit.edu	37	chr16	7629790	7629790	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttttagcagacagatgaCgcagcaccgacggatggcca	11	8	11	11	3	1	3	0	1	1	2	1	5	1	4	2	2	2	3	2	2	1	3	rs145861898	byFrequency	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:7629790C>T	uc002cys.2	+	6	1270	c.282C>T	c.(280-282)GAC>GAT	p.D94D	A2BP1_uc010buf.1_Silent_p.D94D|A2BP1_uc002cyr.1_Silent_p.D93D|A2BP1_uc002cyt.2_Silent_p.D94D|A2BP1_uc010uxz.1_Silent_p.D137D|A2BP1_uc010uya.1_Intron|A2BP1_uc002cyv.1_Silent_p.D94D|A2BP1_uc010uyb.1_Silent_p.D94D|A2BP1_uc002cyw.2_Silent_p.D114D|A2BP1_uc002cyy.2_Silent_p.D114D|A2BP1_uc002cyx.2_Silent_p.D114D|A2BP1_uc010uyc.1_Silent_p.D114D	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	94					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		AGACAGATGACGCAGCACCGA	0.517													40	56					0	0	0	0	T	7629790	T	T	7629790	2	4	16	1	0	0	0	0	0	0	0	1	3	535	19	1		1	A2BP1	16	7629790	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3848325	7629790	82724963	414	3802											
C16orf68	79091	broad.mit.edu	37	chr16	8736032	8736032	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaggaaatttctgacttgtAcgatcacaccaccatcctgt	12	11	7	11	1	2	2	1	1	1	1	3	4	3	3	3	1	1	1	3	1	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:8736032A>G	uc002cyz.2	+	8	1151	c.875A>G	c.(874-876)TAC>TGC	p.Y292C	C16orf68_uc002cza.2_Missense_Mutation_p.Y236C	NM_024109	NP_077014	Q9BUU2	MET22_HUMAN	hypothetical protein LOC79091	292							methyltransferase activity				0						TCTGACTTGTACGATCACACC	0.478													16	59					0	0	0	0	G	8736032	G	G	8736032	3	3	16	1	0	0	0	0	1	0	0	0	1833	391	14	5	901	5	C16orf68	16	8736032	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	1106242	8736032	81618721	415	3803											
CLN3	1201	broad.mit.edu	37	chr16	28493805	28493805	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccctcacttacaagtcccTggttaatgaaatactcggca	12	10	6	13	1	1	1	1	1	0	0	3	1	2	1	3	2	2	2	3	2	5	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:28493805T>A	uc002dpo.2	-	11	1222	c.899A>T	c.(898-900)CAG>CTG	p.Q300L	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.Q222L|CLN3_uc010vcu.1_Missense_Mutation_p.Q200L|CLN3_uc002dpn.2_Missense_Mutation_p.Q201L|CLN3_uc002dpm.2_Missense_Mutation_p.Q246L|CLN3_uc010vcv.1_Missense_Mutation_p.Q276L|CLN3_uc010byd.2_Missense_Mutation_p.Q300L|CLN3_uc002dpp.2_Missense_Mutation_p.Q300L|CLN3_uc002dpt.1_Missense_Mutation_p.Q200L|CLN3_uc002dpq.1_Missense_Mutation_p.Q252L|CLN3_uc010bye.1_Intron|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.Q173L|CLN3_uc002dpu.1_Missense_Mutation_p.Q198L|CLN3_uc002dpw.1_Missense_Mutation_p.Q147L|CLN3_uc010vcw.1_Missense_Mutation_p.Q246L|CLN3_uc002dqa.2_3'UTR|CLN3_uc010vcx.1_3'UTR|CLN3_uc002dpx.1_Missense_Mutation_p.Q177L|CLN3_uc002dpy.1_Missense_Mutation_p.Q144L	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	300					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						TACAAGTCCCTGGTTAATGAA	0.547													22	38					0	0	0	0	A	28493805	A	A	28493805	3	1	16	1	0	0	0	0	1	0	0	0	3558	1580	55	5	437	5	CLN3	16	28493805	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	19757773	28493805	61860948	416	3804											
SEPHS2	22928	broad.mit.edu	37	chr16	30456594	30456594	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcacgttggcacaagctatgCgccccatcatgtagggatct	9	9	11	12	2	2	0	1	0	1	0	2	1	2	1	2	2	2	5	2	2	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:30456594C>A	uc010ves.1	-	2	631	c.455G>T	c.(454-456)CGC>CTC	p.R152L	SEPHS2_uc002dyh.1_Missense_Mutation_p.R95L|SEPHS2_uc010vet.1_Missense_Mutation_p.R34L	NM_012248	NP_036380	Q99611	SPS2_HUMAN	selenophosphate synthetase 2	152					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(2)	2						ACAAGCTATGCGCCCCATCAT	0.547													23	46					5.35047e-06	5.83274e-06	1	0	A	30456594	A	A	30456594	3	1	16	1	0	0	0	0	1	0	0	0	14120	768	27	3	895	3	SEPHS2	16	30456594	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1962789	30456594	59898159	417	3805											
ITFG1	81533	broad.mit.edu	37	chr16	47345160	47345160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatttccttaccttccagatGtgttctttagtatgaccaga	10	16	6	9	0	1	3	0	1	1	2	3	3	3	3	4	0	1	2	4	0	4	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:47345160G>A	uc002eet.2	-	10	1123	c.1061C>T	c.(1060-1062)ACA>ATA	p.T354I	ITFG1_uc010vgg.1_Missense_Mutation_p.T99I|ITFG1_uc010vgh.1_Missense_Mutation_p.T241I	NM_030790	NP_110417	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	354						extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				CCTTCCAGATGTGTTCTTTAG	0.353													15	25					0	0	0	0	A	47345160	A	A	47345160	3	1	16	1	0	0	0	0	1	0	0	0	7908	1377	48	4	813	4	ITFG1	16	47345160	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	16888566	47345160	43009593	418	3806											
CNGB1	1258	broad.mit.edu	37	chr16	57931410	57931410	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacccgtgcgccaccacgtTggccgtgcgccggttcccgc	5	6	12	18	7	0	0	0	0	0	0	1	0	1	0	6	2	3	2	6	2	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:57931410T>A	uc002emt.2	-	31	3198	c.3133A>T	c.(3133-3135)AAC>TAC	p.N1045Y	CNGB1_uc010cdh.2_Missense_Mutation_p.N1039Y	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	1045	Cytoplasmic (Potential).|cAMP (By similarity).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GCCACCACGTTGGCCGTGCGC	0.557													14	33					0	0	0	0	A	57931410	A	A	57931410	3	1	16	1	0	0	0	0	1	0	0	0	3615	1812	63	5	634	5	CNGB1	16	57931410	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	10586250	57931410	32423343	419	3807											
CDH8	1006	broad.mit.edu	37	chr16	61935119	61935119	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggcacagtagcatgataggGtccattaagaaactctggtg	12	10	12	7	0	1	2	0	1	1	1	2	2	2	2	1	3	2	3	1	3	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:61935119G>T	uc002eog.1	-	3	763	c.511C>A	c.(511-513)CCC>ACC	p.P171T		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	171	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GCATGATAGGGTCCATTAAGA	0.398													30	59					4.02929e-09	4.73035e-09	1	0	T	61935119	T	T	61935119	3	4	16	1	0	0	0	0	1	0	0	0	3131	1261	44	4	1928	4	CDH8	16	61935119	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4003709	61935119	28419634	420	3808											
CDH11	1009	broad.mit.edu	37	chr16	64984725	64984725	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggcgcctgtgctcaggccGgcgttcagaatgtaggcctc	6	8	15	12	3	2	1	2	0	0	1	3	1	2	1	3	4	1	3	3	4	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:64984725G>A	uc002eoi.2	-	12	2273	c.1839C>T	c.(1837-1839)GCC>GCT	p.A613A	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.A613A|CDH11_uc010vin.1_Silent_p.A487A	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	613	Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TGCTCAGGCCGGCGTTCAGAA	0.637			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			13	25					0	0	0	0	A	64984725	A	A	64984725	2	1	16	1	0	0	0	0	0	0	0	1	3112	1103	39	1		1	CDH11	16	64984725	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3049606	64984725	25370028	421	3809											
CDH11	1009	broad.mit.edu	37	chr16	65022110	65022110	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatagtccgttgtgatttCaaacgattccataccatctc	10	15	5	11	2	3	1	2	1	1	0	6	2	5	1	3	0	2	1	3	0	3	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:65022110C>A	uc002eoi.2	-	7	1383	c.949G>T	c.(949-951)GAA>TAA	p.E317*	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Nonsense_Mutation_p.E317*|CDH11_uc010vin.1_Nonsense_Mutation_p.E191*	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	317	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GTTGTGATTTCAAACGATTCC	0.443			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			71	106					9.42754e-34	1.4219e-33	1	0	A	65022110	A	A	65022110	4	1	16	1	0	0	0	0	0	1	0	0	3112	835	29	2	1469	2	CDH11	16	65022110	Nonsense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	37385	65022110	25332643	422	3810											
SLC12A4	6560	broad.mit.edu	37	chr16	67981323	67981323	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggcctcggatcccgtcaccCcactccttctcagccctgca	6	8	7	20	2	2	0	2	0	1	0	6	1	4	1	6	2	2	1	6	2	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:67981323C>T	uc002euz.2	-	16	2124	c.1983G>A	c.(1981-1983)TGG>TGA	p.W661*	SLC12A4_uc010ceu.2_Nonsense_Mutation_p.W655*|SLC12A4_uc010vkh.1_Nonsense_Mutation_p.W630*|SLC12A4_uc010vki.1_Nonsense_Mutation_p.W661*|SLC12A4_uc010vkj.1_Nonsense_Mutation_p.W663*|SLC12A4_uc002eva.2_Nonsense_Mutation_p.W661*|SLC12A4_uc010cev.1_RNA|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	661					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCCCGTCACCCCACTCCTTCT	0.667													5	10					0	0	0	0	T	67981323	T	T	67981323	4	4	16	1	0	0	0	0	0	1	0	0	14450	624	22	4	1310	4	SLC12A4	16	67981323	Nonsense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2959213	67981323	22373430	423	3811											
NFAT5	10725	broad.mit.edu	37	chr16	69727108	69727108	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagacttctacaacctcctCtgaacaaatgcagcctccaa	13	9	4	15	0	3	2	1	1	2	1	5	2	5	2	4	0	5	1	4	0	5	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:69727108C>G	uc002exm.1	+	12	4534	c.3326C>G	c.(3325-3327)TCT>TGT	p.S1109C	NFAT5_uc002exi.2_Missense_Mutation_p.S1033C|NFAT5_uc002exj.1_Missense_Mutation_p.S1033C|NFAT5_uc002exk.1_Missense_Mutation_p.S1033C|NFAT5_uc002exl.1_Missense_Mutation_p.S1127C|NFAT5_uc002exn.1_Missense_Mutation_p.S1126C|NFAT5_uc002exo.1_RNA	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	1109					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						ACAACCTCCTCTGAACAAATG	0.438													35	122					0	0	0	0	G	69727108	G	G	69727108	3	3	16	1	0	0	0	0	1	0	0	0	10414	913	32	2	3430	2	NFAT5	16	69727108	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1745785	69727108	20627645	424	3812											
ZFHX3	463	broad.mit.edu	37	chr16	72821667	72821667	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccgccgccggtggggacgTgaagcaccatctcttgcagg	6	6	15	14	5	1	1	0	1	1	0	2	2	1	2	4	4	2	2	4	4	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:72821667T>A	uc002fck.2	-	10	11181	c.10508A>T	c.(10507-10509)CAC>CTC	p.H3503L	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Missense_Mutation_p.H2589L	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3503					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				gGTGGGGACGTGAAGCACCAT	0.433													13	29					0	0	0	0	A	72821667	A	A	72821667	3	1	16	1	0	0	0	0	1	0	0	0	17701	1696	59	5	607	5	ZFHX3	16	72821667	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	3094559	72821667	17533086	425	3813											
ANKRD11	29123	broad.mit.edu	37	chr16	89351869	89351869	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caataggtgcttgtcgtccaCcggaggaaccctgtcctgct	7	10	11	13	2	0	0	0	0	0	0	3	2	2	2	4	3	3	2	4	3	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr16:89351869C>A	uc002fmx.1	-	9	1542	c.1081G>T	c.(1081-1083)GTG>TTG	p.V361L	ANKRD11_uc002fmy.1_Missense_Mutation_p.V361L|ANKRD11_uc002fnc.1_Missense_Mutation_p.V361L|ANKRD11_uc002fnb.1_Missense_Mutation_p.V318L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	361						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTGTCGTCCACCGGAGGAACC	0.468													60	125					1.92745e-42	2.94166e-42	1	0	A	89351869	A	A	89351869	3	1	16	1	0	0	0	0	1	0	0	0	639	507	18	4	6930	4	ANKRD11	16	89351869	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	16530202	89351869	1002884	426	3814											
PRPF8	10594	broad.mit.edu	37	chr17	1576801	1576801	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacacgaagctgttctcccaCtgaactgtagtcactgaccg	10	9	9	13	2	2	2	1	2	1	0	3	4	2	2	2	0	2	3	2	0	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:1576801C>A	uc002fte.2	-	23	3621	c.3507G>T	c.(3505-3507)CAG>CAT	p.Q1169H		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1169						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TGTTCTCCCACTGAACTGTAG	0.547													29	57					2.4375e-19	3.36008e-19	1	0	A	1576801	A	A	1576801	3	1	16	1	0	0	0	0	1	0	0	0	12637	564	20	4	3584	4	PRPF8	17	1576801	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08		1576801	79618409	427	3815											
OR3A1	4994	broad.mit.edu	37	chr17	3195410	3195410	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggtcagtgcgttggtgAaagcacaagcccaggacgca	10	7	15	9	2	1	1	1	1	0	0	1	2	1	2	1	3	3	3	1	3	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:3195410A>G	uc002fvh.1	-	1	467	c.467T>C	c.(466-468)TTC>TCC	p.F156S		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						TGCGTTGGTGAAAGCACAAGC	0.572													47	102					0	0	0	0	G	3195410	G	G	3195410	3	3	16	1	0	0	0	0	1	0	0	0	11091	246	9	5	484	5	OR3A1	17	3195410	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	1618609	3195410	77999800	428	3816											
ALOX12	239	broad.mit.edu	37	chr17	6913397	6913397	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgatgtccggcaggcctgTcttcaaatggccatctcatg	7	11	10	13	1	3	1	2	1	2	0	5	1	4	1	4	3	0	1	4	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:6913397T>C	uc002gdx.3	+	13	1817	c.1764T>C	c.(1762-1764)TGT>TGC	p.C588C	uc002gdy.1_Intron|ALOX12_uc002gdz.3_Silent_p.C58C|RNASEK_uc002gea.2_5'Flank|C17orf49_uc002geb.3_5'Flank|C17orf49_uc002gec.2_5'Flank	NM_000697	NP_000688	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	588	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			central_nervous_system(1)	1						GGCAGGCCTGTCTTCAAATGG	0.562													13	34					0	0	0	0	C	6913397	C	C	6913397	2	2	16	1	0	0	0	0	0	0	0	1	536	1673	58	5		5	ALOX12	17	6913397	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	3717987	6913397	74281813	429	3817											
NLGN2	57555	broad.mit.edu	37	chr17	7317751	7317751	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaacatgttcgatggctcAgtcctggctgcctatggcaa	9	10	12	10	1	1	0	1	0	0	0	3	2	2	1	2	4	2	4	2	4	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:7317751A>T	uc002ggt.1	+	3	670	c.597A>T	c.(595-597)TCA>TCT	p.S199S		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	199	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				TCGATGGCTCAGTCCTGGCTG	0.597													27	73					0	0	0	0	T	7317751	T	T	7317751	2	4	16	1	0	0	0	0	0	0	0	1	10516	175	7	5		5	NLGN2	17	7317751	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	404354	7317751	73877459	430	3818											
TP53	7157	broad.mit.edu	37	chr17	7577568	7577568	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcccatgcaggaactgttaCacatgtagttgtagtggatg	10	11	12	8	1	0	0	0	0	0	0	0	2	0	2	1	2	3	5	1	2	4	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:7577568C>A	uc002gim.2	-	7	907	c.713G>T	c.(712-714)TGT>TTT	p.C238F	TP53_uc002gig.1_Missense_Mutation_p.C238F|TP53_uc002gih.2_Missense_Mutation_p.C238F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106F|TP53_uc010cng.1_Missense_Mutation_p.C106F|TP53_uc002gii.1_Missense_Mutation_p.C106F|TP53_uc010cnh.1_Missense_Mutation_p.C238F|TP53_uc010cni.1_Missense_Mutation_p.C238F|TP53_uc002gij.2_Missense_Mutation_p.C238F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145F|TP53_uc002gio.2_Missense_Mutation_p.C106F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(34)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C238del(1)|p.C238G(1)|p.C238C(1)|p.M237fs*1(1)|p.C145F(1)|p.H233fs*6(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.M237_C238insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	62					1.2644e-06	1.3998e-06	1	0	A	7577568	A	A	7577568	3	1	16	1	0	0	0	0	1	0	0	0	16448	478	17	4	577	4	TP53	17	7577568	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	259817	7577568	73617642	431	3819											
TP53	7157	broad.mit.edu	37	chr17	7578463	7578463	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatggccatggcgcggacgCgggtgccgggcgggggtgtg	4	5	23	9	6	0	1	0	0	0	1	0	2	0	2	2	7	1	0	2	7	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:7578463C>G	uc002gim.2	-	5	661	c.467G>C	c.(466-468)CGC>CCC	p.R156P	TP53_uc002gig.1_Missense_Mutation_p.R156P|TP53_uc002gih.2_Missense_Mutation_p.R156P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R24P|TP53_uc010cng.1_Missense_Mutation_p.R24P|TP53_uc002gii.1_Missense_Mutation_p.R24P|TP53_uc010cnh.1_Missense_Mutation_p.R156P|TP53_uc010cni.1_Missense_Mutation_p.R156P|TP53_uc002gij.2_Missense_Mutation_p.R156P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R63P|TP53_uc002gio.2_Missense_Mutation_p.R24P|TP53_uc010vug.1_Missense_Mutation_p.R117P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	156	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R156P(24)|p.R156H(10)|p.R156fs*14(8)|p.0?(7)|p.R156S(3)|p.R156R(3)|p.R156fs*25(3)|p.R156G(3)|p.R156L(3)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.P153fs*22(2)|p.R156C(2)|p.T155_R156delTR(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156del(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.G154_R156delGTR(1)|p.R156fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCGCGGACGCGGGTGCCGGG	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	43					0	0	0	0	G	7578463	G	G	7578463	3	3	16	1	0	0	0	0	1	0	0	0	16448	768	27	3	831	3	TP53	17	7578463	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	895	7578463	73616747	432	3820											
DNAH2	146754	broad.mit.edu	37	chr17	7734089	7734089	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggacatgtcacagatgactgGgaccggcgcctgctgaccac	9	6	13	13	2	1	3	1	2	0	1	1	5	1	5	3	3	1	1	3	3	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:7734089G>T	uc002giu.1	+	78	12173	c.12159G>T	c.(12157-12159)TGG>TGT	p.W4053C	DNAH2_uc010cnm.1_Missense_Mutation_p.W991C	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4053					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAGATGACTGGGACCGGCGCC	0.547													18	43					3.41278e-10	4.08896e-10	1	0	T	7734089	T	T	7734089	3	4	16	1	0	0	0	0	1	0	0	0	4624	1241	43	4	12469	4	DNAH2	17	7734089	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	155626	7734089	73461121	433	3821											
ARHGEF15	22899	broad.mit.edu	37	chr17	8219105	8219105	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcctgtcccgtgtgcgctCttccccccacatcagcgact	4	10	8	19	3	2	0	1	0	1	0	5	1	5	0	5	0	2	2	5	0	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:8219105C>A	uc002glc.2	+	8	1575	c.1454C>A	c.(1453-1455)TCT>TAT	p.S485Y	ARHGEF15_uc002gld.2_Missense_Mutation_p.S485Y|ARHGEF15_uc010vuw.1_Missense_Mutation_p.S374Y	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	485	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CGTGTGCGCTCTTCCCCCCAC	0.577													17	18					5.35267e-07	5.97746e-07	1	0	A	8219105	A	A	8219105	3	1	16	1	0	0	0	0	1	0	0	0	898	913	32	2	1480	2	ARHGEF15	17	8219105	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	485016	8219105	72976105	434	3822											
PIK3R6	146850	broad.mit.edu	37	chr17	8707437	8707437	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggtcccggctctggatcTggatattgttcgtcctgaag	5	14	12	10	2	3	1	0	1	3	0	6	3	5	3	2	4	0	2	2	4	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:8707437T>C	uc002glq.1	-	20	2270	c.2030A>G	c.(2029-2031)CAG>CGG	p.Q677R	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	677					platelet activation	cytosol					0						GCTCTGGATCTGGATATTGTT	0.587													12	20					0	0	0	0	C	8707437	C	C	8707437	3	2	16	1	0	0	0	0	1	0	0	0	11978	1580	55	5	242	5	PIK3R6	17	8707437	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	488332	8707437	72487773	435	3823											
GAS7	8522	broad.mit.edu	37	chr17	10101583	10101583	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggagcccgtcctccttctcgCcttcccaccagccgccgtcc	3	8	8	22	4	1	0	0	0	1	0	6	1	5	1	9	1	2	0	9	1	0	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:10101583C>A	uc002gmg.1	-	1	286	c.125G>T	c.(124-126)GGC>GTC	p.G42V		NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	42	SH3.				cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						CTCCTTCTCGCCTTCCCACCA	0.726			T	MLL	AML*								17	31					8.34094e-07	9.25007e-07	1	0	A	10101583	A	A	10101583	3	1	16	1	0	0	0	0	1	0	0	0	6285	739	26	4	1419	4	GAS7	17	10101583	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1394146	10101583	71093627	436	3824											
DNAH9	1770	broad.mit.edu	37	chr17	11757566	11757566	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcaagaccccgagttcaatCctgagtttgtggccaccaaa	11	9	9	12	1	1	2	1	1	0	1	2	3	2	2	5	1	1	3	5	1	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:11757566C>A	uc002gne.2	+	50	9822	c.9754C>A	c.(9754-9756)CCT>ACT	p.P3252T	DNAH9_uc010coo.2_Missense_Mutation_p.P2546T	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3252	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CGAGTTCAATCCTGAGTTTGT	0.488													40	106					1.69901e-12	2.15657e-12	1	0	A	11757566	A	A	11757566	3	1	16	1	0	0	0	0	1	0	0	0	4630	855	30	2	9952	2	DNAH9	17	11757566	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1655983	11757566	69437644	437	3825											
UBB	7314	broad.mit.edu	37	chr17	16285753	16285753	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtgacaccatcgaaaatGtgaaggccaagatccaagat	16	6	9	10	1	0	4	0	2	0	2	2	5	1	4	4	1	0	0	4	1	5	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:16285753G>A	uc002gpx.2	+	2	670	c.532G>A	c.(532-534)GTG>ATG	p.V178M	UBB_uc010vwe.1_Missense_Mutation_p.V102M	NM_018955	NP_061828	P0CG47	UBB_HUMAN	ubiquitin B precursor	178	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		CATCGAAAATGTGAAGGCCAA	0.552													21	47					0	0	0	0	A	16285753	A	A	16285753	3	1	16	1	0	0	0	0	1	0	0	0	16909	1377	48	4	534	4	UBB	17	16285753	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4528187	16285753	64909457	438	3826											
TRIM16L	147166	broad.mit.edu	37	chr17	18638707	18638707	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccaagaaggaaaacgccatCcggattgtagatctgggaga	14	7	12	8	2	1	3	0	0	1	3	3	6	3	5	3	3	1	1	3	3	5	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:18638707C>A	uc002gug.1	+	10	1668	c.981C>A	c.(979-981)ATC>ATA	p.I327I	TRIM16L_uc010vyf.1_Silent_p.I381I|TRIM16L_uc002guh.1_Silent_p.I327I|TRIM16L_uc010cqg.1_Silent_p.I429I|TRIM16L_uc002gui.1_Silent_p.I327I|TRIM16L_uc010vyg.1_Silent_p.I327I|TRIM16L_uc010vyh.1_3'UTR	NM_001037330	NP_001032407	Q309B1	TR16L_HUMAN	tripartite motif-containing 16-like	327	B30.2/SPRY.					cytoplasm					0						AAAACGCCATCCGGATTGTAG	0.527													8	33					3.52763e-06	3.87858e-06	1	0	A	18638707	A	A	18638707	2	1	16	1	0	0	0	0	0	0	0	1	16559	845	30	2		2	TRIM16L	17	18638707	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2352954	18638707	62556503	439	3827											
ACCN1	40	broad.mit.edu	37	chr17	32483062	32483062	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagagcatcatatccttcaGgtcatggcccacacggtgca	10	9	10	12	1	3	1	3	0	0	1	4	1	4	1	2	3	2	3	2	3	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:32483062G>T	uc002hhu.2	-	1	764	c.490C>A	c.(490-492)CTG>ATG	p.L164M		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	164	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	ATATCCTTCAGGTCATGGCCC	0.557													23	72					1.1804e-14	1.54731e-14	1	0	T	32483062	T	T	32483062	3	4	16	1	0	0	0	0	1	0	0	0	128	991	35	4	1800	4	ACCN1	17	32483062	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	13844355	32483062	48712148	440	3828											
UNC45B	146862	broad.mit.edu	37	chr17	33497240	33497241	+	Frame_Shift_Ins	INS	-	C	C																															gacgactttgtccaggacgtINSccctgccctgcaggccatgt																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:33497240_33497241insC	uc002hja.2	+	12	1752_1753	c.1655_1656insC	c.(1654-1656)GTCfs	p.V552fs	UNC45B_uc002hjb.2_Frame_Shift_Ins_p.V552fs|UNC45B_uc002hjc.2_Frame_Shift_Ins_p.V552fs|UNC45B_uc010cto.2_Intron	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	552					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				GTCCAGGACGTCCCTGCCCTGC	0.619													---	---	---								C	33497241	C	C	33497240	7	5	16	1	0	1	1	0	0	0	0	0	17057	1667	58	0	1697	0	UNC45B	17	33497240	Frame_Shift_Ins	INS	-	TCGA-BA-6869-01A-11D-1870-08	1014178	33497240	47697970	441	3829											
GAS2L2	246176	broad.mit.edu	37	chr17	34074283	34074283	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaggaagctgcctggcttGtgtgctaccaacagtccccc	7	10	10	14	0	1	0	1	0	0	0	2	1	2	1	4	2	5	3	4	2	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:34074283G>A	uc002hjv.1	-	5	865	c.837C>T	c.(835-837)CAC>CAT	p.H279H		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	279					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCCTGGCTTGTGTGCTACCA	0.597													52	101					0	0	0	0	A	34074283	A	A	34074283	2	1	16	1	0	0	0	0	0	0	0	1	6282	1368	48	4		4	GAS2L2	17	34074283	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	577043	34074283	47120927	442	3830											
TADA2A	6871	broad.mit.edu	37	chr17	35818669	35818669	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctatcattccaggttaaaGgagagacaaagacgaaaaaa	20	7	8	6	1	2	2	1	0	1	2	3	5	3	3	1	2	0	1	1	2	7	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:35818669G>T	uc002hnt.2	+	9	805	c.648G>T	c.(646-648)AAG>AAT	p.K216N	TADA2A_uc002hnu.1_Missense_Mutation_p.K216N|TADA2A_uc002hnv.2_Missense_Mutation_p.K216N|TADA2A_uc010wdd.1_Missense_Mutation_p.K216N|TADA2A_uc002hnw.2_Missense_Mutation_p.K115N|TADA2A_uc010cvb.2_Missense_Mutation_p.K12N	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	216					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						CCAGGTTAAAGGAGAGACAAA	0.229													13	34					2.32078e-09	2.7346e-09	1	0	T	35818669	T	T	35818669	3	4	16	1	0	0	0	0	1	0	0	0	15576	991	35	4	678	4	TADA2A	17	35818669	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1744386	35818669	45376541	443	3831											
ORMDL3	94103	broad.mit.edu	37	chr17	38079494	38079494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagggtgtccccttcaccGtgtgcaggaagatatacatg	11	9	11	10	1	1	1	1	0	0	1	2	2	2	2	3	2	2	1	3	2	4	3	rs139204234	byFrequency	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:38079494G>A	uc002htj.1	-	3	337	c.197C>T	c.(196-198)ACG>ATG	p.T66M	ORMDL3_uc002hti.1_RNA|ORMDL3_uc002htk.1_Missense_Mutation_p.T66M	NM_139280	NP_644809	Q8N138	ORML3_HUMAN	ORM1-like 3	66	Lumenal (Potential).				ceramide metabolic process	integral to membrane|SPOTS complex	protein binding				0	Colorectal(19;0.000442)		Lung(15;0.0234)			CCCCTTCACCGTGTGCAGGAA	0.582													39	120					0	0	0	0	A	38079494	A	A	38079494	3	1	16	1	0	0	0	0	1	0	0	0	11325	1145	40	1	272	1	ORMDL3	17	38079494	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2260825	38079494	43115716	444	3832											
STAT5B	6777	broad.mit.edu	37	chr17	40362219	40362219	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccaagcaatggtgatgcCgccaatttctgagtcactga	10	11	9	11	1	2	3	1	3	1	0	3	3	3	3	3	1	2	1	3	1	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:40362219C>A	uc002hzh.2	-	15	2045	c.1876G>T	c.(1876-1878)GGC>TGC	p.G626C		NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	626	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	ATGGTGATGCCGCCAATTTCT	0.428													30	51					2.12542e-12	2.68716e-12	1	0	A	40362219	A	A	40362219	3	1	16	1	0	0	0	0	1	0	0	0	15335	652	23	3	507	3	STAT5B	17	40362219	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2282725	40362219	40832991	445	3833											
PLEKHH3	79990	broad.mit.edu	37	chr17	40822701	40822701	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagtcgggcgagtcctccaAcccagcttcctccgcggcca	6	6	12	17	4	0	0	0	0	0	0	5	2	4	1	6	3	2	1	6	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:40822701A>T	uc002iau.2	-	10	1911	c.1444T>A	c.(1444-1446)TTG>ATG	p.L482M	PLEKHH3_uc010cyl.1_RNA|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Intron|PLEKHH3_uc002iaw.2_Missense_Mutation_p.L479M	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	482	FERM.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GAGTCCTCCAACCCAGCTTCC	0.672													17	19					0	0	0	0	T	40822701	T	T	40822701	3	4	16	1	0	0	0	0	1	0	0	0	12133	40	2	5	953	5	PLEKHH3	17	40822701	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	460482	40822701	40372509	446	3834											
ARL4D	379	broad.mit.edu	37	chr17	41477216	41477216	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggaaagacctccctcctttAccgcctcaagttcaaggagt	10	10	8	13	1	2	1	2	0	0	1	4	3	4	3	5	2	1	1	5	2	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:41477216A>T	uc002idt.2	+	2	297	c.116A>T	c.(115-117)TAC>TTC	p.Y39F		NM_001661	NP_001652	P49703	ARL4D_HUMAN	ADP-ribosylation factor-like 4D	39					protein secretion|small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)	1		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.155)		TCCCTCCTTTACCGCCTCAAG	0.592													20	40					0	0	0	0	T	41477216	T	T	41477216	3	4	16	1	0	0	0	0	1	0	0	0	940	391	14	5	118	5	ARL4D	17	41477216	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	654515	41477216	39717994	447	3835											
GPATCH8	23131	broad.mit.edu	37	chr17	42475961	42475961	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttccaagccagactcttCacacttcttattgggctttc	7	15	5	14	0	3	1	1	0	2	1	5	1	4	1	3	1	1	1	3	1	2	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:42475961C>A	uc002igw.1	-	8	3548	c.3484G>T	c.(3484-3486)GAA>TAA	p.E1162*	GPATCH8_uc002igv.1_Nonsense_Mutation_p.E1084*|GPATCH8_uc010wiz.1_Nonsense_Mutation_p.E1084*	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1162						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CCAGACTCTTCACACTTCTTA	0.542													50	121					1.32667e-27	1.95493e-27	1	0	A	42475961	A	A	42475961	4	1	16	1	0	0	0	0	0	1	0	0	6632	835	29	2	1028	2	GPATCH8	17	42475961	Nonsense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	998745	42475961	38719249	448	3836											
ADAM11	4185	broad.mit.edu	37	chr17	42852065	42852065	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccgcctggctcacccctcaGgggactgcaagtgtccagac	7	7	11	16	1	2	1	2	0	0	1	4	2	4	2	5	3	1	2	5	3	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:42852065G>T	uc002ihh.2	+	14	1169	c.1169_splice	c.e14-1	p.G390_splice	ADAM11_uc010wjd.1_Splice_Site_p.G190_splice|ADAM11_uc002ihi.2_5'Flank	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein						integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				TCACCCCTCAGGGGACTGCAA	0.652													11	47					6.40141e-05	6.77113e-05	1	0	T	42852065	T	T	42852065	5	4	16	1	0	0	0	0	0	0	1	0	235	1014	35	4	1222	4	ADAM11	17	42852065	Splice_Site	SNP	G	TCGA-BA-6869-01A-11D-1870-08	376104	42852065	38343145	449	3837											
MAPT	4137	broad.mit.edu	37	chr17	44068882	44068882	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagcagcccctccaggccaGaagggccaggccaacgccac	10	1	13	17	1	0	1	0	0	0	1	1	2	1	2	7	4	3	1	7	4	2	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:44068882G>C	uc002ijr.3	+	9	1757	c.1437G>C	c.(1435-1437)CAG>CAC	p.Q479H	MAPT_uc010dau.2_Missense_Mutation_p.Q479H|MAPT_uc002ijs.3_Missense_Mutation_p.Q162H|MAPT_uc002ijx.3_Missense_Mutation_p.Q133H|MAPT_uc002ijt.3_Missense_Mutation_p.Q104H|MAPT_uc002iju.3_Missense_Mutation_p.Q104H|MAPT_uc002ijv.3_Missense_Mutation_p.Q111H	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	479					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CTCCAGGCCAGAAGGGCCAGG	0.542													37	94					0	0	0	0	C	44068882	C	C	44068882	3	2	16	1	0	0	0	0	1	0	0	0	9350	933	33	2	1467	2	MAPT	17	44068882	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1216817	44068882	37126328	450	3838											
OR4D2	124538	broad.mit.edu	37	chr17	56247544	56247544	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccccaacattttggataaCttctactgtgatgttcccca	9	13	7	12	0	1	1	0	1	1	0	2	2	2	2	4	2	3	1	4	2	3	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:56247544C>T	uc010wnp.1	+	1	528	c.528C>T	c.(526-528)AAC>AAT	p.N176N		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TTTTGGATAACTTCTACTGTG	0.547													48	99					0	0	0	0	T	56247544	T	T	56247544	2	4	16	1	0	0	0	0	0	0	0	1	11110	564	20	4		4	OR4D2	17	56247544	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	12178662	56247544	24947666	451	3839											
C17orf82	388407	broad.mit.edu	37	chr17	59489603	59489603	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtctcctgggcaccctccCgggagcgccttcggggtgga	3	7	17	14	3	1	0	0	0	1	0	4	2	2	2	4	6	1	1	4	6	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:59489603C>T	uc002izh.1	+	1	492	c.267C>T	c.(265-267)CCC>CCT	p.P89P		NM_203425	NP_982249	Q86X59	CQ082_HUMAN	hypothetical protein LOC388407	89											0						GGCACCCTCCCGGGAGCGCCT	0.721											OREG0024630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	7					0	0	0	0	T	59489603	T	T	59489603	2	4	16	1	0	0	0	0	0	0	0	1	1895	639	23	1		1	C17orf82	17	59489603	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3242059	59489603	21705607	452	3840											
CSH1	1442	broad.mit.edu	37	chr17	61972895	61972895	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatagtcatcgctgtccgAggtgtcatacaccaggttgt	8	12	12	9	2	2	1	2	1	0	0	4	2	3	1	2	2	1	2	2	2	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:61972895A>T	uc002jcs.1	-	4	510	c.394T>A	c.(394-396)TCG>ACG	p.S132T	CSH2_uc002jck.2_Intron|CSH1_uc002jcp.1_Missense_Mutation_p.S93T|CSH1_uc002jcq.1_Missense_Mutation_p.S93T|CSH1_uc002jcr.1_3'UTR|CSH1_uc002jct.1_Missense_Mutation_p.S98T|CSH1_uc002jcu.1_Missense_Mutation_p.S132T|CSH1_uc002jcv.1_Intron|CSH1_uc002jcw.2_Missense_Mutation_p.S132T|CSH1_uc002jcy.2_3'UTR	NM_001317	NP_001308	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 1 isoform 1	132					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			skin(1)	1						TCGCTGTCCGAGGTGTCATAC	0.592									Russell-Silver_syndrome				17	31					0	0	0	0	T	61972895	T	T	61972895	3	4	16	1	0	0	0	0	1	0	0	0	3957	304	11	5	516	5	CSH1	17	61972895	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	2483292	61972895	19222315	453	3841											
ABCA6	23460	broad.mit.edu	37	chr17	67136824	67136824	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctttggtttgctgatacacGcttttctgtttcatattcat	6	20	7	8	1	3	1	2	1	1	0	3	1	3	1	0	1	2	5	0	1	2	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:67136824G>T	uc002jhw.1	-	2	196	c.21C>A	c.(19-21)AGC>AGA	p.S7R	ABCA6_uc002jhy.2_Missense_Mutation_p.S5R	NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	7					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					GCTGATACACGCTTTTCTGTT	0.333													23	52					7.87624e-14	1.01788e-13	1	0	T	67136824	T	T	67136824	3	4	16	1	0	0	0	0	1	0	0	0	36	1078	38	3	4984	3	ABCA6	17	67136824	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	5163929	67136824	14058386	454	3842											
C17orf77	146723	broad.mit.edu	37	chr17	72588218	72588218	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctgtcattttccctgacAtgtctccttcctgagaacag	7	13	8	13	1	2	2	1	2	1	1	5	3	4	2	3	0	1	1	3	0	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr17:72588218A>T	uc002jla.1	+	3	395	c.33A>T	c.(31-33)ACA>ACT	p.T11T	CD300LD_uc002jkz.2_Intron	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	11						extracellular region					0						TTTCCCTGACATGTCTCCTTC	0.478													48	92					0	0	0	0	T	72588218	T	T	72588218	2	4	16	1	0	0	0	0	0	0	0	1	1890	204	8	5		5	C17orf77	17	72588218	Silent	SNP	A	TCGA-BA-6869-01A-11D-1870-08	5451394	72588218	8606992	455	3843											
DLGAP1	9229	broad.mit.edu	37	chr18	3879384	3879384	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtactgtgaggccgagcggtCggggcacctgcccatggtca	6	7	16	12	3	1	1	1	1	0	0	2	2	1	1	3	5	3	2	3	5	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:3879384C>G	uc002kmf.2	-	1	752	c.685G>C	c.(685-687)GAC>CAC	p.D229H	DLGAP1_uc010wyz.1_Missense_Mutation_p.D229H|DLGAP1_uc002kmk.2_Missense_Mutation_p.D229H|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	229					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GCCGAGCGGTCGGGGCACCTG	0.647													152	187					0	0	0	0	G	3879384	G	G	3879384	3	3	16	1	0	0	0	0	1	0	0	0	4581	884	31	3	2343	3	DLGAP1	18	3879384	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08		3879384	74197864	456	3844											
DLGAP1	9229	broad.mit.edu	37	chr18	3879506	3879506	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgggccttgggctccgcgCgccgctccttgctcttgctg	0	10	14	17	5	1	0	0	0	1	0	3	0	3	0	5	2	2	4	5	2	0	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:3879506C>G	uc002kmf.2	-	1	630	c.563G>C	c.(562-564)CGC>CCC	p.R188P	DLGAP1_uc010wyz.1_Missense_Mutation_p.R188P|DLGAP1_uc002kmk.2_Missense_Mutation_p.R188P|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	188					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane		p.R188C(1)		ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GGGCTCCGCGCGCCGCTCCTT	0.711													53	258					0	0	0	0	G	3879506	G	G	3879506	3	3	16	1	0	0	0	0	1	0	0	0	4581	768	27	3	2465	3	DLGAP1	18	3879506	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	122	3879506	74197742	457	3845											
ASXL3	80816	broad.mit.edu	37	chr18	31224903	31224903	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatgcaatgcttcacactaaCactcgaataggggatggaac	15	8	9	9	1	1	0	1	0	0	0	2	3	1	2	0	3	4	2	0	3	6	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:31224903C>T	uc010dmg.1	+	3	238	c.183C>T	c.(181-183)AAC>AAT	p.N61N	ASXL3_uc002kxq.2_5'UTR	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	61					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TTCACACTAACACTCGAATAG	0.393													3	8					0	0	0	0	T	31224903	T	T	31224903	2	4	16	1	0	0	0	0	0	0	0	1	1070	477	17	4		4	ASXL3	18	31224903	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	27345397	31224903	46852345	458	3846											
SETBP1	26040	broad.mit.edu	37	chr18	42532199	42532199	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagctaatcaccaagttccAagtgttcagaatctcccacc	12	9	7	13	0	3	1	2	0	1	1	5	2	4	2	4	1	1	3	4	1	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:42532199A>G	uc010dni.2	+	4	3190	c.2894A>G	c.(2893-2895)CAA>CGA	p.Q965R		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	965						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		ACCAAGTTCCAAGTGTTCAGA	0.473									Schinzel-Giedion_syndrome				52	58					0	0	0	0	G	42532199	G	G	42532199	3	3	16	1	0	0	0	0	1	0	0	0	14194	130	5	5	3097	5	SETBP1	18	42532199	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	11307296	42532199	35545049	459	3847											
SLC14A1	6563	broad.mit.edu	37	chr18	43316445	43316445	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttctcaagtgcattgaaTtccatgctcagcaaatggga	12	13	8	8	0	2	1	2	1	1	0	4	2	3	2	1	1	3	3	1	1	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:43316445T>C	uc010xcn.1	+	7	814	c.495T>C	c.(493-495)AAT>AAC	p.N165N	SLC14A1_uc010dnk.2_Silent_p.N221N|SLC14A1_uc002lbf.3_Silent_p.N165N|SLC14A1_uc002lbg.3_Intron|SLC14A1_uc010xco.1_Silent_p.N60N|SLC14A1_uc002lbh.3_Silent_p.N57N|SLC14A1_uc002lbi.3_Silent_p.N33N|SLC14A1_uc002lbj.3_Silent_p.N221N|SLC14A1_uc002lbk.3_Silent_p.N165N	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	165						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						GTGCATTGAATTCCATGCTCA	0.458													34	114					0	0	0	0	C	43316445	C	C	43316445	2	2	16	1	0	0	0	0	0	0	0	1	14461	1490	52	5		5	SLC14A1	18	43316445	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	784246	43316445	34760803	460	3848											
TCEB3C	162699	broad.mit.edu	37	chr18	44555173	44555173	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgccgagggcgtccggattGttcctaggcacccggaggca	6	7	15	13	5	0	0	0	0	0	0	3	3	2	2	4	5	0	3	4	5	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:44555173G>A	uc010xdb.1	-	1	1277	c.1041C>T	c.(1039-1041)AAC>AAT	p.N347N	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	347	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						CGTCCGGATTGTTCCTAGGCA	0.647													24	600					0	0	0	0	A	44555173	A	A	44555173	2	1	16	1	0	0	0	0	0	0	0	1	15749	1368	48	4		4	TCEB3C	18	44555173	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1238728	44555173	33522075	461	3849											
MBD1	4152	broad.mit.edu	37	chr18	47806252	47806252	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgcccactacccacccagtaCctctggtaataggtgtctga	9	10	8	14	0	2	1	0	1	2	0	2	1	2	1	4	2	3	2	4	2	4	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:47806252C>T	uc010dow.1	-	2	547	c.110_splice	c.e2+1	p.S37_splice	MBD1_uc002lef.2_5'Flank|MBD1_uc002leg.2_Splice_Site_p.S37_splice|MBD1_uc010xdi.1_Splice_Site_p.S63_splice|MBD1_uc002leh.3_Splice_Site_p.S37_splice|MBD1_uc002len.2_Splice_Site_p.S37_splice|MBD1_uc002lei.3_Splice_Site_p.S37_splice|MBD1_uc002lej.3_Splice_Site_p.S37_splice|MBD1_uc002lek.3_Splice_Site_p.S37_splice|MBD1_uc002lel.3_Splice_Site_p.S37_splice|MBD1_uc002lem.3_Splice_Site_p.S37_splice|MBD1_uc010xdj.1_Splice_Site_p.S37_splice|MBD1_uc010xdk.1_Splice_Site_p.S37_splice|MBD1_uc010dox.1_Intron|MBD1_uc002leo.2_Splice_Site_p.S37_splice	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1						negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCACCCAGTACCTCTGGTAAT	0.537													16	50					0	0	0	0	T	47806252	T	T	47806252	5	4	16	1	0	0	0	0	0	0	1	0	9395	521	18	4	1960	4	MBD1	18	47806252	Splice_Site	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3251079	47806252	30270996	462	3850											
MRO	83876	broad.mit.edu	37	chr18	48331580	48331580	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgaagaaggaacccaaacCtttcccctggatcttgccca	12	9	7	13	0	1	2	0	1	1	1	2	4	2	4	5	2	3	0	5	2	5	3	rs143359256	by1000genomes	TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:48331580C>T	uc002lew.3	-	5	667	c.373G>A	c.(373-375)GGT>AGT	p.G125S	MRO_uc010xdn.1_Missense_Mutation_p.G125S|MRO_uc010dpa.2_Missense_Mutation_p.G139S|MRO_uc010dpb.2_Missense_Mutation_p.G139S|MRO_uc010dpc.2_Missense_Mutation_p.G125S|MRO_uc002lex.3_Missense_Mutation_p.G125S	NM_031939	NP_114145	Q9BYG7	MSTRO_HUMAN	maestro isoform a	125						nucleolus	binding				0		Colorectal(6;0.0596)		Colorectal(21;0.082)		GAACCCAAACCTTTCCCCTGG	0.433													50	45					0	0	0	0	T	48331580	T	T	48331580	3	4	16	1	0	0	0	0	1	0	0	0	9825	681	24	4	389	4	MRO	18	48331580	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	525328	48331580	29745668	463	3851											
DCC	1630	broad.mit.edu	37	chr18	50450211	50450211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttacctggttacgaggcgagGaagtcatccaactcaggtat	11	10	11	9	2	2	0	2	0	0	0	3	3	3	1	2	4	3	2	2	4	5	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:50450211G>A	uc002lfe.1	+	4	1419	c.832G>A	c.(832-834)GAA>AAA	p.E278K	DCC_uc010xdr.1_Missense_Mutation_p.E126K	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	278	Extracellular (Potential).|Ig-like C2-type 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ACGAGGCGAGGAAGTCATCCA	0.368													41	48					0	0	0	0	A	50450211	A	A	50450211	3	1	16	1	0	0	0	0	1	0	0	0	4299	1175	41	2	846	2	DCC	18	50450211	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2118631	50450211	27627037	464	3852											
CDH19	28513	broad.mit.edu	37	chr18	64239255	64239255	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaataagtacctggccgaTgtgatgactagtcgtattca	13	12	9	7	2	1	2	1	2	0	0	2	3	1	2	2	1	1	2	2	1	6	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:64239255T>C	uc002lkc.1	-	2	325	c.187A>G	c.(187-189)ATC>GTC	p.I63V	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.I63V|CDH19_uc002lkd.2_Missense_Mutation_p.I63V	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	63	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				ACCTGGCCGATGTGATGACTA	0.378													17	38					0	0	0	0	C	64239255	C	C	64239255	3	2	16	1	0	0	0	0	1	0	0	0	3119	1464	51	5	2175	5	CDH19	18	64239255	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	13789044	64239255	13837993	465	3853											
CNDP1	84735	broad.mit.edu	37	chr18	72247448	72247448	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgactctaggactacaccCgtggattgcaaatattgatg	12	11	9	9	1	1	2	0	2	1	0	1	4	1	4	1	2	2	1	1	2	4	5	rs144587048		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:72247448C>G	uc002llq.2	+	10	1461	c.1250C>G	c.(1249-1251)CCG>CGG	p.P417R	CNDP1_uc002lls.2_Missense_Mutation_p.P220R	NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	417					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		GGACTACACCCGTGGATTGCA	0.443													12	36					0	0	0	0	G	72247448	G	G	72247448	3	3	16	1	0	0	0	0	1	0	0	0	3608	652	23	3	1288	3	CNDP1	18	72247448	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	8008193	72247448	5829800	466	3854											
NFATC1	4772	broad.mit.edu	37	chr18	77170505	77170505	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccttcagacctccacacCgggcatcatcccgccggcgg	8	5	9	19	4	2	1	2	0	0	1	4	1	4	1	6	3	1	1	6	3	1	1	rs143045693		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr18:77170505C>T	uc010xfg.1	+	2	683	c.230C>T	c.(229-231)CCG>CTG	p.P77L	NFATC1_uc002lnc.1_Missense_Mutation_p.P77L|NFATC1_uc010xff.1_Missense_Mutation_p.P77L|NFATC1_uc002lnd.2_Missense_Mutation_p.P77L|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Missense_Mutation_p.P77L|NFATC1_uc010xfi.1_Missense_Mutation_p.P64L|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Missense_Mutation_p.P64L|NFATC1_uc002lng.2_Missense_Mutation_p.P64L|NFATC1_uc010xfk.1_Missense_Mutation_p.P64L	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	77					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		ACCTCCACACCGGGCATCATC	0.692													32	37					0	0	0	0	T	77170505	T	T	77170505	3	4	16	1	0	0	0	0	1	0	0	0	10415	652	23	1	328	1	NFATC1	18	77170505	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4923057	77170505	906743	467	3855											
ELANE	1991	broad.mit.edu	37	chr19	852883	852883	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtgtgtccccaggcaccgcGctggcctcggagattgtggg	4	8	17	12	3	0	1	0	0	0	1	2	2	1	1	4	5	0	2	4	5	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:852883G>A	uc002lqb.2	+	2	113	c.75G>A	c.(73-75)GCG>GCA	p.A25A		NM_001972	NP_001963	P08246	ELNE_HUMAN	neutrophil elastase preproprotein	25			A -> V (in SCN1).		cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			pancreas(1)	1					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CAGGCACCGCGCTGGCCTCGG	0.741									Kostmann_syndrome				11	8					0	0	0	0	A	852883	A	A	852883	2	1	16	1	0	0	0	0	0	0	0	1	5072	1074	38	1		1	ELANE	19	852883	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08		852883	58276100	468	3856											
APC2	10297	broad.mit.edu	37	chr19	1466497	1466497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcgcaagaggggccactctCgctgtcccgatgcagctccc	6	6	13	16	3	1	1	0	0	1	1	4	2	3	1	3	3	2	4	3	3	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:1466497C>T	uc002lsr.1	+	15	3405	c.3197C>T	c.(3196-3198)TCG>TTG	p.S1066L	APC2_uc002lss.1_Missense_Mutation_p.S648L|APC2_uc002lst.1_Missense_Mutation_p.S1066L|APC2_uc002lsu.1_Missense_Mutation_p.S1065L|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1066	Interaction with CTNNB1.|1.|5 X 20 AA approximate repeat of F-X-V-E- X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCCACTCTCGCTGTCCCGA	0.682													5	10					0	0	0	0	T	1466497	T	T	1466497	3	4	16	1	0	0	0	0	1	0	0	0	764	893	31	1	3251	1	APC2	19	1466497	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	613614	1466497	57662486	469	3857											
MUC16	94025	broad.mit.edu	37	chr19	9070007	9070007	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ataacttctgtcctggagacCtcagtagtagtagtagtggg	10	12	12	7	0	2	1	1	0	1	1	3	2	3	1	2	2	1	4	2	2	5	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:9070007C>G	uc002mkp.2	-	3	17643	c.17439G>C	c.(17437-17439)GAG>GAC	p.E5813D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5815	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCTGGAGACCTCAGTAGTAG	0.493													21	75					0	0	0	0	G	9070007	G	G	9070007	3	3	16	1	0	0	0	0	1	0	0	0	10026	680	24	4	26412	4	MUC16	19	9070007	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	7603510	9070007	50058976	470	3858											
MUC16	94025	broad.mit.edu	37	chr19	9075389	9075389	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtccatgtaagggctgacGtccctcagttcaatagtcaa	10	11	10	10	1	3	1	3	1	0	0	5	1	5	1	2	1	0	3	2	1	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:9075389G>A	uc002mkp.2	-	3	12261	c.12057C>T	c.(12055-12057)GAC>GAT	p.D4019D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4021	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAGGGCTGACGTCCCTCAGTT	0.473													27	56					0	0	0	0	A	9075389	A	A	9075389	2	1	16	1	0	0	0	0	0	0	0	1	10026	1136	40	1		1	MUC16	19	9075389	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	5382	9075389	50053594	471	3859											
DNM2	1785	broad.mit.edu	37	chr19	10893766	10893766	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacatggccgaccgcatgggCacgccacatctgcagaagac	11	4	11	15	3	1	2	0	0	1	2	1	3	1	2	3	2	1	3	3	2	1	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:10893766C>T	uc002mps.1	+	6	983	c.819C>T	c.(817-819)GGC>GGT	p.G273G	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.G273G|DNM2_uc002mpv.1_Silent_p.G273G|DNM2_uc002mpu.1_Silent_p.G273G|DNM2_uc010dxl.1_Silent_p.G273G|DNM2_uc002mpw.2_Silent_p.G6G	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	273					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			ACCGCATGGGCACGCCACATC	0.577													15	47					0	0	0	0	T	10893766	T	T	10893766	2	4	16	1	0	0	0	0	0	0	0	1	4694	697	25	4		4	DNM2	19	10893766	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1818377	10893766	48235217	472	3860											
ZNF443	10224	broad.mit.edu	37	chr19	12542408	12542408	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tacatttataaggtccatctCcacgctgcactgccatgtgt	9	13	7	12	1	1	0	0	0	1	0	3	0	2	0	3	1	3	2	3	1	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:12542408C>G	uc002mtu.2	-	4	776	c.578G>C	c.(577-579)GGA>GCA	p.G193A		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	193					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						AGGTCCATCTCCACGCTGCAC	0.418													36	93					0	0	0	0	G	12542408	G	G	12542408	3	3	16	1	0	0	0	0	1	0	0	0	17983	855	30	2	1441	2	ZNF443	19	12542408	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1648642	12542408	46586575	473	3861											
CCDC130	81576	broad.mit.edu	37	chr19	13869957	13869957	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gagacggacgccatgttccgGctggagcatggcgaggccga	8	5	17	11	5	0	1	0	0	0	1	1	6	1	3	3	5	1	3	3	5	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:13869957G>T	uc002mxb.1	+	9	947	c.444G>T	c.(442-444)CGG>CGT	p.R148R	CCDC130_uc010xnf.1_3'UTR|CCDC130_uc002mxc.1_Silent_p.R148R|CCDC130_uc002mxd.1_Silent_p.R3R|CCDC130_uc010dzf.1_Silent_p.R42R	NM_030818	NP_110445	P13994	CC130_HUMAN	coiled-coil domain containing 130	148					response to virus		protein binding				0			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			CCATGTTCCGGCTGGAGCATG	0.652													4	10					0.00909568	0.00929877	1	0	T	13869957	T	T	13869957	2	4	16	1	0	0	0	0	0	0	0	1	2778	1190	42	4		4	CCDC130	19	13869957	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1327549	13869957	45259026	474	3862											
RFX1	5989	broad.mit.edu	37	chr19	14104570	14104570	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgggggtggtggcggtggcGgctggggctgggcttgtggc	0	9	25	7	2	0	0	0	0	0	0	0	0	0	0	0	11	0	3	0	11	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:14104570G>A	uc002mxv.2	-	2	358	c.86C>T	c.(85-87)CCG>CTG	p.P29L	RFX1_uc010dzi.2_Missense_Mutation_p.P29L	NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	29					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			tggcggtggcggctggggctg	0.129													5	15					0	0	0	0	A	14104570	A	A	14104570	3	1	16	1	0	0	0	0	1	0	0	0	13327	1116	39	1	2933	1	RFX1	19	14104570	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	234613	14104570	45024413	475	3863											
FCHO1	23149	broad.mit.edu	37	chr19	17887482	17887482	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccagagacctcggtctgccCccagaaccagcaggtgggtt	8	6	12	15	1	1	2	0	0	1	2	2	3	1	2	5	3	3	2	5	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:17887482C>G	uc010ebb.2	+	17	1435	c.1246C>G	c.(1246-1248)CCC>GCC	p.P416A	FCHO1_uc002nhg.3_Missense_Mutation_p.P416A|FCHO1_uc002nhh.2_Missense_Mutation_p.P416A|FCHO1_uc010xpw.1_Missense_Mutation_p.P366A|FCHO1_uc002nhi.2_5'Flank|FCHO1_uc002nhj.2_5'Flank	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	416										breast(1)	1						TCGGTCTGCCCCCAGAACCAG	0.597													13	41					0	0	0	0	G	17887482	G	G	17887482	3	3	16	1	0	0	0	0	1	0	0	0	5819	623	22	4	1304	4	FCHO1	19	17887482	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	3782912	17887482	41241501	476	3864											
ZNF90	7643	broad.mit.edu	37	chr19	20229413	20229413	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaatgtggcaaagccttCaggcgctccttagtccttcg	9	10	11	11	2	1	1	1	0	0	1	4	2	3	1	3	2	1	2	3	2	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:20229413C>A	uc002nor.2	+	4	1189	c.1050C>A	c.(1048-1050)TTC>TTA	p.F350L	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	350	C2H2-type 7.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GCAAAGCCTTCAGGCGCTCCT	0.423													14	23					6.81908e-15	8.97542e-15	1	0	A	20229413	A	A	20229413	3	1	16	1	0	0	0	0	1	0	0	0	18266	825	29	2	1064	2	ZNF90	19	20229413	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2341931	20229413	38899570	477	3865											
ZNF430	80264	broad.mit.edu	37	chr19	21205625	21205625	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctggagtgtatcctctcAaggaagcaagtggatgccct	10	10	12	9	0	2	0	1	0	2	0	4	3	3	3	2	3	2	2	2	3	4	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:21205625A>T	uc002npj.2	+	2	144	c.34A>T	c.(34-36)AAG>TAG	p.K12*	ZNF430_uc002npk.2_Nonsense_Mutation_p.K12*	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	12					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						GTATCCTCTCAAGGAAGCAAG	0.448													33	74					0	0	0	0	T	21205625	T	T	21205625	4	4	16	1	0	0	0	0	0	1	0	0	17971	131	5	5	40	5	ZNF430	19	21205625	Nonsense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	976212	21205625	37923358	478	3866											
ZNF208	7757	broad.mit.edu	37	chr19	22154585	22154585	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacattcttcacatttgtagGgttcctctccagcatgagtt	8	15	7	11	0	3	1	1	1	2	0	5	1	4	1	2	1	1	4	2	1	1	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:22154585G>T	uc002nqp.2	-	6	3016	c.2867C>A	c.(2866-2868)CCC>CAC	p.P956H	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATTTGTAGGGTTCCTCTCC	0.428													36	86					1.03484e-13	1.33467e-13	1	0	T	22154585	T	T	22154585	3	4	16	1	0	0	0	0	1	0	0	0	17833	1232	43	4	595	4	ZNF208	19	22154585	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	948960	22154585	36974398	479	3867											
ZNF676	163223	broad.mit.edu	37	chr19	22363718	22363718	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	attgccttatgtgtattaagGgttgagacgctactaaatcc	11	14	9	7	1	0	1	0	1	0	1	1	2	1	1	2	1	2	3	2	1	6	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:22363718G>A	uc002nqs.1	-	3	1119	c.801C>T	c.(799-801)ACC>ACT	p.T267T		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	267	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GTGTATTAAGGGTTGAGACGC	0.388													23	60					0	0	0	0	A	22363718	A	A	22363718	2	1	16	1	0	0	0	0	0	0	0	1	18150	1219	43	4		4	ZNF676	19	22363718	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	209133	22363718	36765265	480	3868											
LGI4	163175	broad.mit.edu	37	chr19	35617862	35617862	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacaatgtgaggctccccttGgtaggagaagggctctacgc	9	8	13	11	1	1	2	0	1	1	1	2	3	2	2	2	4	1	3	2	4	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:35617862G>A	uc002nxx.2	-	7	1282	c.688C>T	c.(688-690)CAA>TAA	p.Q230*	LGI4_uc002nxy.1_Nonsense_Mutation_p.Q58*|LGI4_uc002nxz.1_Nonsense_Mutation_p.Q58*	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	230	EAR 1.					extracellular region				pancreas(1)	1	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GGCTCCCCTTGGTAGGAGAAG	0.652													15	43					0	0	0	0	A	35617862	A	A	35617862	4	1	16	1	0	0	0	0	0	1	0	0	8795	1357	47	4	937	4	LGI4	19	35617862	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	13254144	35617862	23511121	481	3869											
ZNF568	374900	broad.mit.edu	37	chr19	37488355	37488355	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcaaaaagttcacactgggGagagaccccataagtgtaag	16	7	10	8	0	2	1	2	0	0	1	2	3	2	2	2	2	0	2	2	2	4	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:37488355G>T	uc010efg.2	+	10	2277	c.1720G>T	c.(1720-1722)GAG>TAG	p.E574*	ZNF568_uc010xtn.1_Nonsense_Mutation_p.E512*|uc010efi.2_Nonsense_Mutation_p.E392*|uc010efj.2_Nonsense_Mutation_p.E392*			Q3ZCX4	ZN568_HUMAN	SubName: Full=cDNA FLJ57578, moderately similar to Mus musculus zinc finger protein 568 (Zfp568), mRNA;	611					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCACACTGGGGAGAGACCCCA	0.448													5	13					0.000602214	0.000626655	1	0	T	37488355	T	T	37488355	4	4	16	1	0	0	0	0	0	1	0	0	18066	1189	41	2		2	ZNF568	19	37488355	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1870493	37488355	21640628	482	3870											
RYR1	6261	broad.mit.edu	37	chr19	38948913	38948913	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctattcctacggctttgaTggactgcatctctggacagg	7	13	10	11	1	2	1	0	1	2	0	4	3	3	3	1	4	2	2	1	4	2	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:38948913T>A	uc002oit.2	+	18	2278	c.2148T>A	c.(2146-2148)GAT>GAA	p.D716E	RYR1_uc002oiu.2_Missense_Mutation_p.D716E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	716	Cytoplasmic.|B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACGGCTTTGATGGACTGCATC	0.632													23	79					0	0	0	0	A	38948913	A	A	38948913	3	1	16	1	0	0	0	0	1	0	0	0	13833	1461	51	5	2218	5	RYR1	19	38948913	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	1460558	38948913	20180070	483	3871											
DYRK1B	9149	broad.mit.edu	37	chr19	40317964	40317964	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcgtagggtccagccaccCccaggcagccgttcaaagta	9	7	10	15	2	1	0	1	0	0	0	3	0	2	0	5	2	2	4	5	2	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:40317964C>A	uc002omj.2	-	8	1336	c.1056G>T	c.(1054-1056)GGG>GGT	p.G352G	DYRK1B_uc002omi.2_Silent_p.G352G|DYRK1B_uc002omk.2_Silent_p.G352G	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	352	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			TCCAGCCACCCCCAGGCAGCC	0.647													14	23					6.72482e-11	8.22636e-11	1	0	A	40317964	A	A	40317964	2	1	16	1	0	0	0	0	0	0	0	1	4877	610	22	4		4	DYRK1B	19	40317964	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1369051	40317964	18811019	484	3872											
HNRNPUL1	11100	broad.mit.edu	37	chr19	41809959	41809959	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaacaactccaacaacagAggcagctacaaccgggctcc	16	3	7	15	1	0	1	0	0	0	1	2	1	2	1	3	2	8	3	3	2	7	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:41809959A>T	uc002oqb.3	+	13	2344	c.2055A>T	c.(2053-2055)AGA>AGT	p.R685S	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Missense_Mutation_p.R585S|HNRNPUL1_uc002oqa.3_Missense_Mutation_p.R585S|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.R685S|HNRNPUL1_uc002oqc.3_Missense_Mutation_p.R571S|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Missense_Mutation_p.R585S|HNRNPUL1_uc010ehn.2_Missense_Mutation_p.R585S|HNRNPUL1_uc010eho.2_Missense_Mutation_p.R585S|HNRNPUL1_uc010xvy.1_Missense_Mutation_p.R585S|HNRNPUL1_uc010ehp.2_Missense_Mutation_p.R541S|HNRNPUL1_uc002oqf.3_Missense_Mutation_p.R209S	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	685	Necessary for interaction with TP53.|Asn-rich.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						CCAACAACAGAGGCAGCTACA	0.388													37	56					0	0	0	0	T	41809959	T	T	41809959	3	4	16	1	0	0	0	0	1	0	0	0	7313	301	11	5	2105	5	HNRNPUL1	19	41809959	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	1491995	41809959	17319024	485	3873											
EXOC3L2	90332	broad.mit.edu	37	chr19	45731307	45731307	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actcctggctgatgcggggtGctcgctctgtgtgctcttcc	2	13	13	13	2	2	1	0	1	2	0	5	1	4	1	2	3	3	4	2	3	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:45731307G>A	uc002pay.1	-	4	259	c.218C>T	c.(217-219)GCA>GTA	p.A73V		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	73										ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		GATGCGGGGTGCTCGCTCTGT	0.637													8	26					0	0	0	0	A	45731307	A	A	45731307	3	1	16	1	0	0	0	0	1	0	0	0	5329	1319	46	4	1039	4	EXOC3L2	19	45731307	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3921348	45731307	13397676	486	3874											
CCDC155	147872	broad.mit.edu	37	chr19	49902726	49902726	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttggtcaggaaaaggagcagCagcatctggtggctgagatg	11	8	16	6	0	2	1	1	1	1	1	2	4	2	3	0	5	3	4	0	5	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:49902726C>G	uc002pnm.1	+	9	934	c.760C>G	c.(760-762)CAG>GAG	p.Q254E	CCDC155_uc002pnl.1_Missense_Mutation_p.Q254E|CCDC155_uc010emx.1_Missense_Mutation_p.Q227E	NM_144688	NP_653289	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	254	Potential.					integral to membrane	calcium ion binding			ovary(1)|central_nervous_system(1)	2						AAAGGAGCAGCAGCATCTGGT	0.572													7	9					0	0	0	0	G	49902726	G	G	49902726	3	3	16	1	0	0	0	0	1	0	0	0	2801	711	25	4	790	4	CCDC155	19	49902726	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	4171419	49902726	9226257	487	3875											
HAS1	3036	broad.mit.edu	37	chr19	52222623	52222623	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctcccgataggctccggCgcccaccgcgcccgccgccg	4	3	11	23	8	0	0	0	0	0	0	2	1	2	0	8	2	0	1	8	2	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:52222623C>A	uc002pxo.1	-	2	573	c.538G>T	c.(538-540)GCC>TCC	p.A180S	HAS1_uc010epc.1_5'Flank|HAS1_uc010epd.1_Missense_Mutation_p.A145S|HAS1_uc002pxn.1_Missense_Mutation_p.A187S|HAS1_uc002pxp.1_Missense_Mutation_p.A179S	NM_001523	NP_001514	Q92839	HAS1_HUMAN	hyaluronan synthase 1	180	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			ovary(1)|pancreas(1)	2		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TAGGCTccggcgcccaccgcg	0.587													3	8					0.004672	0.0047916	1	0	A	52222623	A	A	52222623	3	1	16	1	0	0	0	0	1	0	0	0	7000	768	27	3	1214	3	HAS1	19	52222623	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2319897	52222623	6906360	488	3876											
FPR2	2358	broad.mit.edu	37	chr19	52272136	52272136	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggctgacttttctttcacGgccacattaccattcctcat	7	15	5	14	1	3	1	2	1	1	0	4	1	4	1	3	2	1	1	3	2	1	5	rs147854636		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:52272136G>C	uc002pxr.2	+	2	270	c.225G>C	c.(223-225)ACG>ACC	p.T75T	FPR2_uc002pxs.3_Silent_p.T75T|FPR2_uc010epf.2_Silent_p.T75T	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	75	Helical; Name=2; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						TTTCTTTCACGGCCACATTAC	0.512													28	88					0	0	0	0	C	52272136	C	C	52272136	2	2	16	1	0	0	0	0	0	0	0	1	6073	1103	39	3		3	FPR2	19	52272136	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	49513	52272136	6856847	489	3877											
PTPRH	5794	broad.mit.edu	37	chr19	55707974	55707974	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatggtggctgggtaggaccGagccggcccgagacccaaca	9	4	16	12	3	0	1	0	0	0	1	0	5	0	2	4	5	2	2	4	5	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:55707974G>A	uc002qjq.2	-	10	2246	c.2173C>T	c.(2173-2175)CGG>TGG	p.R725W	PTPRH_uc010esv.2_Missense_Mutation_p.R547W|PTPRH_uc002qjs.2_Missense_Mutation_p.R732W	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	725	Extracellular (Potential).|Fibronectin type-III 8.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GGGTAGGACCGAGCCGGCCCG	0.632													29	44					0	0	0	0	A	55707974	A	A	55707974	3	1	16	1	0	0	0	0	1	0	0	0	12868	1057	37	1	1218	1	PTPRH	19	55707974	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3435838	55707974	3421009	490	3878											
BRSK1	84446	broad.mit.edu	37	chr19	55817783	55817783	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acgggacggcagcggaggtgGtggcatctactccgtcacct	7	7	15	12	4	2	0	1	0	1	0	3	2	3	2	2	6	2	2	2	6	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:55817783G>A	uc002qkg.2	+	17	2331	c.2054G>A	c.(2053-2055)GGT>GAT	p.G685D	BRSK1_uc002qkf.2_Missense_Mutation_p.G701D|BRSK1_uc002qkh.2_Missense_Mutation_p.G380D	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	685					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		AGCGGAGGTGGTGGCATCTAC	0.642													9	33					0	0	0	0	A	55817783	A	A	55817783	3	1	16	1	0	0	0	0	1	0	0	0	1528	1261	44	4	2120	4	BRSK1	19	55817783	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	109809	55817783	3311200	491	3879											
ZNF256	10172	broad.mit.edu	37	chr19	58453833	58453833	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgtctgtatacagtttctGaccatggtgtgttccttggt	5	16	10	10	1	2	1	0	1	2	0	3	1	3	1	3	2	1	3	3	2	2	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:58453833G>T	uc002qqu.2	-	3	578	c.343C>A	c.(343-345)CAG>AAG	p.Q115K	ZNF256_uc010euj.2_5'UTR	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	115					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		TACAGTTTCTGACCATGGTGT	0.473													42	103					3.66854e-30	5.49424e-30	1	0	T	58453833	T	T	58453833	3	4	16	1	0	0	0	0	1	0	0	0	17866	1299	45	2	1544	2	ZNF256	19	58453833	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2636050	58453833	675150	492	3880											
ZNF324	25799	broad.mit.edu	37	chr19	58983146	58983146	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcccttcgcctgcccacaGtgcggccgcgcctttagcca	6	7	10	18	4	0	0	0	0	0	0	1	0	0	0	6	1	4	0	6	1	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr19:58983146G>C	uc002qsw.1	+	4	1381	c.1287G>C	c.(1285-1287)CAG>CAC	p.Q429H	ZNF324_uc002qsx.1_Missense_Mutation_p.Q206H	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	429	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CCTGCCCACAGTGCGGCCGCG	0.677													14	31					0	0	0	0	C	58983146	C	C	58983146	3	2	16	1	0	0	0	0	1	0	0	0	17911	1020	36	4	1297	4	ZNF324	19	58983146	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	529313	58983146	145837	493	3881											
C20orf27	54976	broad.mit.edu	37	chr20	3735131	3735131	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcctctttgaggacgccctCtttgtgcgccgagtactcac	5	12	9	15	3	3	1	1	1	2	0	4	3	4	2	3	1	2	1	3	1	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:3735131C>G	uc002wji.1	-	5	566	c.337G>C	c.(337-339)GAG>CAG	p.E113Q	C20orf27_uc002wjf.1_3'UTR|C20orf27_uc002wjh.1_Missense_Mutation_p.E138Q	NM_001039140	NP_001034229	Q9GZN8	CT027_HUMAN	hypothetical protein LOC54976	113											0						AGGACGCCCTCTTTGTGCGCC	0.632													24	53					0	0	0	0	G	3735131	G	G	3735131	3	3	16	1	0	0	0	0	1	0	0	0	2117	922	32	2	195	2	C20orf27	20	3735131	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08		3735131	59290389	494	3882											
PAK7	57144	broad.mit.edu	37	chr20	9561116	9561116	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccagaggggagctactcgaGgctctctgatactcccactt	8	10	10	13	1	1	2	0	1	1	1	5	4	3	3	2	3	3	2	2	3	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:9561116G>T	uc002wnl.2	-	5	1211	c.666C>A	c.(664-666)GCC>GCA	p.A222A	PAK7_uc002wnk.2_Silent_p.A222A|PAK7_uc002wnj.2_Silent_p.A222A|PAK7_uc010gby.1_Silent_p.A222A	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	222	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			AGCTACTCGAGGCTCTCTGAT	0.488													20	43					2.39187e-15	3.17264e-15	1	0	T	9561116	T	T	9561116	2	4	16	1	0	0	0	0	0	0	0	1	11459	987	35	4		4	PAK7	20	9561116	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	5825985	9561116	53464404	495	3883											
FLRT3	23767	broad.mit.edu	37	chr20	14306693	14306694	+	Frame_Shift_Ins	INS	-	T	T																															agtttcatcaaataggtagaINSggttgctggtttccatggga																								rs144984452		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:14306693_14306694insT	uc002wov.1	-	3	1926_1927	c.1459_1460insA	c.(1459-1461)CTCfs	p.L487fs	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Frame_Shift_Ins_p.L487fs	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	487	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		AAATAGGTAGAGGTTGCTGGTT	0.455													---	---	---								T	14306694	T	T	14306693	7	5	16	1	0	1	1	0	0	0	0	0	5972	304	11	0	493	0	FLRT3	20	14306693	Frame_Shift_Ins	INS	-	TCGA-BA-6869-01A-11D-1870-08	4745577	14306693	48718827	496	3884											
C20orf160	140706	broad.mit.edu	37	chr20	30610545	30610545	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtattgagtgtgtggaccGggctggctaccactacacat	9	10	13	9	1	0	1	0	1	0	0	0	3	0	2	2	3	2	3	2	3	3	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:30610545G>T	uc002wxf.2	+	6	1029	c.1016G>T	c.(1015-1017)CGG>CTG	p.R339L	C20orf160_uc002wxg.2_5'UTR	NM_080625	NP_542192	Q9NUG4	CT160_HUMAN	hypothetical protein LOC140706	339										central_nervous_system(3)|ovary(1)	4						TGTGTGGACCGGGCTGGCTAC	0.587													15	46					2.61681e-11	3.23818e-11	1	0	T	30610545	T	T	30610545	3	4	16	1	0	0	0	0	1	0	0	0	2103	1116	39	3	1038	3	C20orf160	20	30610545	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	16303852	30610545	32414975	497	3885											
C20orf114	92747	broad.mit.edu	37	chr20	31877739	31877739	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagctgcaggtgaagccctcGgccaatgaccaggagctgct	9	6	13	13	1	0	2	0	2	0	0	1	3	0	3	3	3	5	4	3	3	2	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:31877739G>T	uc002wyw.1	+	4	467	c.306G>T	c.(304-306)TCG>TCT	p.S102S	C20orf114_uc010gej.1_Silent_p.S102S	NM_033197	NP_149974	Q8TDL5	LPLC1_HUMAN	LPLUNC1 protein precursor	102						extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4						TGAAGCCCTCGGCCAATGACC	0.542													17	47					9.16793e-09	1.06268e-08	1	0	T	31877739	T	T	31877739	2	4	16	1	0	0	0	0	0	0	0	1	2092	1103	39	3		3	C20orf114	20	31877739	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1267194	31877739	31147781	498	3886											
BPI	671	broad.mit.edu	37	chr20	36952317	36952317	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acaatccacctccctttgctCcaccagtgatggagtttccc	8	11	6	16	0	0	1	0	1	0	0	4	2	4	2	6	1	1	2	6	1	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:36952317C>T	uc002xib.2	+	8	876	c.814C>T	c.(814-816)CCA>TCA	p.P272S		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	272					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				TCCCTTTGCTCCACCAGTGAT	0.522													23	45					0	0	0	0	T	36952317	T	T	36952317	3	4	16	1	0	0	0	0	1	0	0	0	1495	855	30	2	844	2	BPI	20	36952317	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	5074578	36952317	26073203	499	3887											
ACTR5	79913	broad.mit.edu	37	chr20	37378668	37378668	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agtagggctgtgttgatcatCccatagttttgacagaagct	10	13	11	7	0	1	3	1	2	0	1	2	3	2	3	1	1	1	5	1	1	3	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:37378668C>T	uc002xjd.2	+	2	416	c.391C>T	c.(391-393)CCC>TCC	p.P131S		NM_024855	NP_079131	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog	131					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding				0		Myeloproliferative disorder(115;0.00878)				TGTTGATCATCCCATAGTTTT	0.413													23	55					0	0	0	0	T	37378668	T	T	37378668	3	4	16	1	0	0	0	0	1	0	0	0	215	855	30	2	397	2	ACTR5	20	37378668	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	426351	37378668	25646852	500	3888											
ZNF831	128611	broad.mit.edu	37	chr20	57769304	57769304	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacagccaccgtatccatcGcctctgcatgggcagcactt	8	9	9	15	2	1	1	0	1	1	0	3	1	2	1	4	1	3	4	4	1	1	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:57769304G>T	uc002yan.2	+	1	3230	c.3230G>T	c.(3229-3231)CGC>CTC	p.R1077L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1077						intracellular	nucleic acid binding|zinc ion binding	p.R1077C(1)		skin(13)|ovary(1)	14	all_lung(29;0.0085)					CGTATCCATCGCCTCTGCATG	0.637													10	32					1.76689e-08	2.02971e-08	1	0	T	57769304	T	T	57769304	3	4	16	1	0	0	0	0	1	0	0	0	18252	1087	38	3	3232	3	ZNF831	20	57769304	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	20390636	57769304	5256216	501	3889											
TAF4	6874	broad.mit.edu	37	chr20	60581806	60581806	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcagctgtctcaaggcgggTaagctcctctgggtggaaag	8	9	15	9	1	3	0	2	0	2	0	5	1	4	1	1	4	2	3	1	4	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:60581806T>C	uc002ybs.2	-	7	1983	c.1983A>G	c.(1981-1983)TTA>TTG	p.L661L		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	661	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TCAAGGCGGGTAAGCTCCTCT	0.587													16	27					0	0	0	0	C	60581806	C	C	60581806	2	2	16	1	0	0	0	0	0	0	0	1	15592	1635	57	5		5	TAF4	20	60581806	Silent	SNP	T	TCGA-BA-6869-01A-11D-1870-08	2812502	60581806	2443714	502	3890											
ZNF512B	57473	broad.mit.edu	37	chr20	62597874	62597874	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgactggcatgggtctgccGaccgagactggcttgctgat	6	10	15	10	2	1	3	0	2	1	1	1	5	1	3	2	3	2	3	2	3	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr20:62597874G>A	uc002yhl.1	-	5	708	c.654C>T	c.(652-654)GTC>GTT	p.V218V		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	218					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TGGGTCTGCCGACCGAGACTG	0.597													65	165					0	0	0	0	A	62597874	A	A	62597874	2	1	16	1	0	0	0	0	0	0	0	1	18024	1045	37	1		1	ZNF512B	20	62597874	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2016068	62597874	427646	503	3891											
KRTAP6-2	337967	broad.mit.edu	37	chr21	31971084	31971084	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccatgaccatagccacagCaggagctatagccacagcgc	13	4	10	14	1	0	1	0	1	0	0	0	2	0	2	4	1	6	2	4	1	3	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:31971084C>G	uc011adc.1	-	1	110	c.110G>C	c.(109-111)TGC>TCC	p.C37S	KRTAP22-1_uc011add.1_5'Flank	NM_181604	NP_853635	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	37						intermediate filament					0						ATAGCCACAGCAGGAGCTATA	0.562													14	39					0	0	0	0	G	31971084	G	G	31971084	3	3	16	1	0	0	0	0	1	0	0	0	8610	710	25	4	81	4	KRTAP6-2	21	31971084	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08		31971084	16158811	504	3892											
SYNJ1	8867	broad.mit.edu	37	chr21	34018775	34018775	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggaagggaaggtacaggacCctctgatattgtaggtgact	11	9	15	6	0	1	2	0	2	1	0	1	5	1	5	1	5	1	2	1	5	5	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:34018775C>A	uc002yqh.2	-	24	3292	c.3292G>T	c.(3292-3294)GGT>TGT	p.G1098C	SYNJ1_uc011ads.1_Missense_Mutation_p.G1054C|SYNJ1_uc002yqf.2_Missense_Mutation_p.G1059C|SYNJ1_uc002yqg.2_Missense_Mutation_p.G1054C|SYNJ1_uc002yqi.2_Missense_Mutation_p.G1098C	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1059	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						GGTACAGGACCCTCTGATATT	0.517													61	99					3.95532e-38	6.00796e-38	1	0	A	34018775	A	A	34018775	3	1	16	1	0	0	0	0	1	0	0	0	15518	623	22	4	1607	4	SYNJ1	21	34018775	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	2047691	34018775	14111120	505	3893											
CLIC6	54102	broad.mit.edu	37	chr21	36042977	36042977	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggtagcggcgaggccgcGcgcgtgaacggccgccggga	6	2	21	12	9	0	1	0	1	0	0	0	4	0	2	3	5	2	1	3	5	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:36042977G>C	uc010gmt.1	+	1	1290	c.1290G>C	c.(1288-1290)GCG>GCC	p.A430A	CLIC6_uc002yuf.1_Silent_p.A430A	NM_053277	NP_444507	Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	430						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						GCGAGGCCGCGCGCGTGAACG	0.741													5	4					0	0	0	0	C	36042977	C	C	36042977	2	2	16	1	0	0	0	0	0	0	0	1	3545	1074	38	3		3	CLIC6	21	36042977	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2024202	36042977	12086918	506	3894											
DSCAM	1826	broad.mit.edu	37	chr21	41505903	41505903	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtccagctccagtgaaggcTgtgtggtggtgatgttttta	6	14	14	7	1	0	2	0	2	0	0	2	2	2	2	2	3	1	3	2	3	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:41505903T>A	uc002yyq.1	-	19	3892	c.3440A>T	c.(3439-3441)CAG>CTG	p.Q1147L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1147	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CAGTGAAGGCTGTGTGGTGGT	0.532													18	38					0	0	0	0	A	41505903	A	A	41505903	3	1	16	1	0	0	0	0	1	0	0	0	4790	1580	55	5	2658	5	DSCAM	21	41505903	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	5462926	41505903	6623992	507	3895											
MCM3AP	8888	broad.mit.edu	37	chr21	47704494	47704494	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaatattgacttaggtcctCtcttctcttcctctacattt	8	18	3	12	0	3	1	0	1	3	0	7	1	5	1	2	1	1	0	2	1	4	7			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:47704494C>G	uc002zir.1	-	1	743	c.707G>C	c.(706-708)AGA>ACA	p.R236T	C21orf57_uc002zit.1_5'Flank|C21orf57_uc002ziu.1_5'Flank|C21orf57_uc002ziv.2_5'Flank|C21orf57_uc002ziw.2_5'Flank|C21orf57_uc002zix.2_5'Flank|C21orf57_uc010gqh.2_5'Flank|C21orf57_uc002ziy.2_5'Flank	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	236					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					CTTAGGTCCTCTCTTCTCTTC	0.393													22	67					0	0	0	0	G	47704494	G	G	47704494	3	3	16	1	0	0	0	0	1	0	0	0	9441	913	32	2	5347	2	MCM3AP	21	47704494	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	6198591	47704494	425401	508	3896											
MCM3AP	8888	broad.mit.edu	37	chr21	47704507	47704507	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtcctctcttctcttcctCtacattttggtttgacaaag	7	17	6	11	0	3	1	0	1	3	0	7	1	5	1	2	2	1	1	2	2	2	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:47704507C>G	uc002zir.1	-	1	730	c.694G>C	c.(694-696)GAG>CAG	p.E232Q	C21orf57_uc002zit.1_5'Flank|C21orf57_uc002ziu.1_5'Flank|C21orf57_uc002ziv.2_5'Flank|C21orf57_uc002ziw.2_5'Flank|C21orf57_uc002zix.2_5'Flank|C21orf57_uc010gqh.2_5'Flank|C21orf57_uc002ziy.2_5'Flank	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	232					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					TTCTCTTCCTCTACATTTTGG	0.388													21	61					0	0	0	0	G	47704507	G	G	47704507	3	3	16	1	0	0	0	0	1	0	0	0	9441	922	32	2	5360	2	MCM3AP	21	47704507	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	13	47704507	425388	509	3897											
PCNT	5116	broad.mit.edu	37	chr21	47821563	47821563	+	Frame_Shift_Del	DEL	G	-	-																															agatgtcccgagcctccttcGggcagccctcctgagggtcc																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr21:47821563delG	uc002zji.3	+	26	4997	c.4890delG	c.(4888-4890)TCGfs	p.S1630fs	PCNT_uc002zjj.2_Frame_Shift_Del_p.S1512fs	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1630	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AGCCTCCTTCGGGCAGCCCTC	0.562													---	---	---								-	47821563	-	-	47821563	7	5	16	1	0	1	0	1	0	0	0	0	11644	1103	39	0	4992	0	PCNT	21	47821563	Frame_Shift_Del	DEL	G	TCGA-BA-6869-01A-11D-1870-08	117056	47821563	308332	510	3898											
OR11H1	81061	broad.mit.edu	37	chr22	16449523	16449523	+	Frame_Shift_Del	DEL	G	-	-																															aggaagttgaccaacatcttGggaactgtagaagagacata																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:16449523delG	uc011agd.1	-	1	282	c.282delC	c.(280-282)CCCfs	p.P94fs		NM_001005239	NP_001005239	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		CCAACATCTTGGGAACTGTAG	0.408													---	---	---								-	16449523	-	-	16449523	7	5	16	1	0	1	0	1	0	0	0	0	10980	1335	47	0	700	0	OR11H1	22	16449523	Frame_Shift_Del	DEL	G	TCGA-BA-6869-01A-11D-1870-08		16449523	34855043	511	3899											
ZNF280B	140883	broad.mit.edu	37	chr22	22843555	22843555	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgttcaaaatgtttgaaaCgactggttttgaatttgaag	12	16	9	4	1	2	3	1	3	1	0	2	4	2	3	0	1	1	3	0	1	5	5			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:22843555C>G	uc002zwc.1	-	4	945	c.169G>C	c.(169-171)GTT>CTT	p.V57L	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		ATGTTTGAAACGACTGGTTTT	0.408													30	56					0	0	0	0	G	22843555	G	G	22843555	3	3	16	1	0	0	0	0	1	0	0	0	17882	536	19	3	1466	3	ZNF280B	22	22843555	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	6394032	22843555	28461011	512	3900											
GNAZ	2781	broad.mit.edu	37	chr22	23465617	23465617	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagtacattggcctttgctGaggagctgggcccggggccc	6	8	15	12	1	0	1	0	1	0	0	0	2	0	2	3	5	3	3	3	5	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:23465617G>A	uc002zwu.1	+	3	1604	c.1067G>A	c.(1066-1068)TGA>TAA	p.*356*	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	356						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		GGCCTTTGCTGAGGAGCTGGG	0.587													6	4					0	0	0	0	A	23465617	A	A	23465617	2	1	16	1	0	0	0	0	0	0	0	1	6551	1285	45	2		2	GNAZ	22	23465617	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	622062	23465617	27838949	513	3901											
SUSD2	56241	broad.mit.edu	37	chr22	24584279	24584279	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtctatgtgctgctgcgcCgcaggaagggcaacacgtga	8	8	14	11	4	1	1	0	1	1	0	2	2	1	2	1	2	4	4	1	2	3	1	rs150371467		TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:24584279C>A	uc002zzn.1	+	14	2472	c.2428C>A	c.(2428-2430)CGC>AGC	p.R810S		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	810	Cytoplasmic (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						GCTGCTGCGCCGCAGGAAGGG	0.657													8	20					0.00621372	0.00636261	1	0	A	24584279	A	A	24584279	3	1	16	1	0	0	0	0	1	0	0	0	15474	652	23	3	2482	3	SUSD2	22	24584279	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	1118662	24584279	26720287	514	3902											
GGT5	2687	broad.mit.edu	37	chr22	24622662	24622662	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccccttggcaaacttgagCgtctctacaaggtggtggta	8	11	12	10	1	1	1	0	1	1	0	2	1	1	1	2	4	4	2	2	4	4	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:24622662C>G	uc002zzo.3	-	7	1392	c.975G>C	c.(973-975)ACG>ACC	p.T325T	GGT5_uc002zzp.3_Silent_p.T325T|GGT5_uc002zzr.3_Silent_p.T293T|GGT5_uc002zzq.3_Silent_p.T293T|GGT5_uc011ajm.1_Silent_p.T248T|GGT5_uc011ajn.1_RNA	NM_004121	NP_004112	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5 isoform b	325	Extracellular (Potential).				glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(2)|skin(1)	3						CAAACTTGAGCGTCTCTACAA	0.612													21	61					0	0	0	0	G	24622662	G	G	24622662	2	3	16	1	0	0	0	0	0	0	0	1	6399	755	27	3		3	GGT5	22	24622662	Silent	SNP	C	TCGA-BA-6869-01A-11D-1870-08	38383	24622662	26681904	515	3903											
CRYBB1	1414	broad.mit.edu	37	chr22	26995525	26995525	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgcttgtcacgcaggcgacGcagggactgcatctgtggct	6	9	14	12	3	2	0	1	0	1	0	2	2	2	1	0	3	2	5	0	3	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:26995525G>T	uc003acy.1	-	6	758	c.688C>A	c.(688-690)CGT>AGT	p.R230S		NM_001887	NP_001878	P53674	CRBB1_HUMAN	crystallin, beta B1	230	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens			ovary(1)	1						CGCAGGCGACGCAGGGACTGC	0.627													21	45					8.10497e-08	9.17895e-08	1	0	T	26995525	T	T	26995525	3	4	16	1	0	0	0	0	1	0	0	0	3925	1087	38	3	74	3	CRYBB1	22	26995525	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2372863	26995525	24309041	516	3904											
RFPL1	5988	broad.mit.edu	37	chr22	29835041	29835041	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttccatggtctctcagaaGaacaaaatcaggcccagttg	12	10	9	10	0	3	2	2	0	1	2	5	2	4	2	2	2	1	2	2	2	4	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:29835041G>A	uc003afn.2	+	1	470	c.261G>A	c.(259-261)AAG>AAA	p.K87K	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	87							zinc ion binding				0						TCTCTCAGAAGAACAAAATCA	0.517													28	70					0	0	0	0	A	29835041	A	A	29835041	2	1	16	1	0	0	0	0	0	0	0	1	13318	933	33	2		2	RFPL1	22	29835041	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2839516	29835041	21469525	517	3905											
DUSP18	150290	broad.mit.edu	37	chr22	31059931	31059931	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcttttggttatctgcgaGaggccgctgactgagggctg	6	11	16	8	2	1	3	0	2	1	1	1	4	1	3	1	4	1	4	1	4	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:31059931G>C	uc003aiu.2	-	2	561	c.60C>G	c.(58-60)CTC>CTG	p.L20L	SLC35E4_uc003ait.2_Intron|DUSP18_uc010gwa.1_RNA|DUSP18_uc003aiw.1_Silent_p.L20L	NM_152511	NP_689724	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	20						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						TTATCTGCGAGAGGCCGCTGA	0.552													15	40					0	0	0	0	C	31059931	C	C	31059931	2	2	16	1	0	0	0	0	0	0	0	1	4839	929	33	2		2	DUSP18	22	31059931	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	1224890	31059931	20244635	518	3906											
GTSE1	51512	broad.mit.edu	37	chr22	46722418	46722418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	catggcgtgtgtcagccttgCccacacccgccagccggcgc	5	6	12	18	4	1	0	1	0	0	0	1	0	1	0	5	2	3	0	5	2	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chr22:46722418C>T	uc011aqy.1	+	9	1803	c.1591C>T	c.(1591-1593)CCC>TCC	p.P531S	GTSE1_uc011aqz.1_Missense_Mutation_p.P378S|GTSE1_uc003bhl.1_Missense_Mutation_p.P156S|GTSE1_uc003bhm.1_Missense_Mutation_p.P156S|GTSE1_uc003bhn.2_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	512					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		GTCAGCCTTGCCCACACCCGC	0.652													21	37					0	0	0	0	T	46722418	T	T	46722418	3	4	16	1	0	0	0	0	1	0	0	0	6924	739	26	4	1621	4	GTSE1	22	46722418	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	15662487	46722418	4582148	519	3907											
GLRA2	2742	broad.mit.edu	37	chrX	14627215	14627215	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcttatagtaattttgtcctGggtttccttttggataaata	9	19	8	5	0	0	0	0	0	0	0	2	1	2	1	2	2	0	3	2	2	6	10			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:14627215G>C	uc010nep.2	+	8	1150	c.818G>C	c.(817-819)TGG>TCG	p.W273S	GLRA2_uc010neq.2_Missense_Mutation_p.W273S|GLRA2_uc004cwe.3_Missense_Mutation_p.W273S|GLRA2_uc011mio.1_Missense_Mutation_p.W184S|GLRA2_uc011mip.1_Missense_Mutation_p.W251S	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	273	Helical; (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	ATTTTGTCCTGGGTTTCCTTT	0.473													51	29					0	0	0	0	C	14627215	C	C	14627215	3	2	16	1	0	0	0	0	1	0	0	0	6492	1357	47	4	916	4	GLRA2	23	14627215	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08		14627215	140643345	520	3908											
NHS	4810	broad.mit.edu	37	chrX	17739579	17739579	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcccatcccccagaggatGaagatacagatgtcatgtta	13	9	9	10	0	1	4	1	1	0	3	3	5	3	5	3	1	1	1	3	1	3	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:17739579G>T	uc004cxx.2	+	4	1209	c.871G>T	c.(871-873)GAA>TAA	p.E291*	NHS_uc011mix.1_Nonsense_Mutation_p.E312*|NHS_uc004cxy.2_Nonsense_Mutation_p.E135*|NHS_uc004cxz.2_Nonsense_Mutation_p.E114*|NHS_uc004cya.2_Nonsense_Mutation_p.E14*	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	291						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CCCAGAGGATGAAGATACAGA	0.433													25	13					4.59853e-10	5.47892e-10	1	0	T	17739579	T	T	17739579	4	4	16	1	0	0	0	0	0	1	0	0	10465	1291	45	2	990	2	NHS	23	17739579	Nonsense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	3112364	17739579	137530981	521	3909											
DMD	1756	broad.mit.edu	37	chrX	32459328	32459328	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagagatttcctcagctccgCcaggaatgttttcagtggtt	8	13	10	10	1	2	1	2	0	0	1	4	3	4	2	3	2	1	3	3	2	1	4			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:32459328C>G	uc004dda.1	-	28	4134	c.3890G>C	c.(3889-3891)GGC>GCC	p.G1297A	DMD_uc004dcz.2_Missense_Mutation_p.G1174A|DMD_uc004dcy.1_Missense_Mutation_p.G1293A|DMD_uc004ddb.1_Missense_Mutation_p.G1289A|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1297	Spectrin 9.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTCAGCTCCGCCAGGAATGTT	0.358													31	21					0	0	0	0	G	32459328	G	G	32459328	3	3	16	1	0	0	0	0	1	0	0	0	4602	739	26	4	7618	4	DMD	23	32459328	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	14719749	32459328	122811232	522	3910											
FAM47B	170062	broad.mit.edu	37	chrX	34962223	34962223	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgggtgtccagtctctgcccGgagcctaccaagaccggagc	7	6	13	15	3	1	1	0	0	1	1	3	3	2	3	5	3	4	0	5	3	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:34962223G>T	uc004ddi.1	+	1	1293	c.1275G>T	c.(1273-1275)CCG>CCT	p.P425P		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	425										ovary(3)|breast(1)	4						GTCTCTGCCCGGAGCCTACCA	0.547													31	10					3.80469e-20	5.27881e-20	1	0	T	34962223	T	T	34962223	2	4	16	1	0	0	0	0	0	0	0	1	5602	1103	39	3		3	FAM47B	23	34962223	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2502895	34962223	120308337	523	3911											
DGKK	139189	broad.mit.edu	37	chrX	50163498	50163498	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagtgatttttcgttgtggtGtaataacctaaacaaaaagc	14	13	9	5	1	0	1	0	1	0	0	1	2	0	1	1	1	3	2	1	1	6	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:50163498G>T	uc010njr.1	-	4	905	c.845C>A	c.(844-846)ACA>AAA	p.T282K		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	282	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TCGTTGTGGTGTAATAACCTA	0.388													39	21					2.59497e-14	3.38085e-14	1	0	T	50163498	T	T	50163498	3	4	16	1	0	0	0	0	1	0	0	0	4494	1377	48	4	3069	4	DGKK	23	50163498	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	15201275	50163498	105107062	524	3912											
TRO	7216	broad.mit.edu	37	chrX	54957428	54957428	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagtggagccgccagtcttgGtgcctgtggcttctcgtatg	4	12	14	11	2	2	0	0	0	2	0	3	1	2	1	3	3	2	2	3	3	1	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:54957428G>T	uc004dtq.2	+	12	4378	c.4271G>T	c.(4270-4272)GGT>GTT	p.G1424V	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_RNA|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.G955V|TRO_uc004dtw.2_Missense_Mutation_p.G1027V|TRO_uc004dtx.2_Missense_Mutation_p.G807V	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1424	62; approximate.|62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						GCCAGTCTTGGTGCCTGTGGC	0.567													9	11					1.11149e-13	1.43065e-13	1	0	T	54957428	T	T	54957428	3	4	16	1	0	0	0	0	1	0	0	0	16641	1261	44	4	4313	4	TRO	23	54957428	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4793930	54957428	100313132	525	3913											
FAM123B	139285	broad.mit.edu	37	chrX	63410293	63410293	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggacagggagcccaagcaggCcaatcataggcccctggggg	10	3	16	12	0	1	0	1	0	0	0	1	2	1	2	4	6	2	1	4	6	3	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:63410293C>A	uc004dvo.2	-	2	3147	c.2874G>T	c.(2872-2874)TGG>TGT	p.W958C		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	958	Pro-rich.				Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CCCAAGCAGGCCAATCATAGG	0.577													15	6					4.7546e-09	5.57167e-09	1	0	A	63410293	A	A	63410293	3	1	16	1	0	0	0	0	1	0	0	0	5451	740	26	4	537	4	FAM123B	23	63410293	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	8452865	63410293	91860267	526	3914											
KIAA2022	340533	broad.mit.edu	37	chrX	73962264	73962265	+	Frame_Shift_Ins	INS	-	A	A																															actttcctctctggccccttINSaaactctgtgtcttgggctt																										TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:73962264_73962265insA	uc004eby.2	-	3	2744_2745	c.2127_2128insT	c.(2125-2130)TTTAAGfs	p.F709fs		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	709_710					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TCTGGCCCCTTAAACTCTGTGT	0.431													---	---	---								A	73962265	A	A	73962264	7	5	16	1	0	1	1	0	0	0	0	0	8308	1763	61	0	2430	0	KIAA2022	23	73962264	Frame_Shift_Ins	INS	-	TCGA-BA-6869-01A-11D-1870-08	10551971	73962264	81308296	527	3915											
BRWD3	254065	broad.mit.edu	37	chrX	79932626	79932626	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atctacgtaatcttgatctgTtctggaagttgattcagagt	10	16	9	6	1	5	3	1	2	4	1	5	4	5	4	0	1	1	3	0	1	3	6			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:79932626T>A	uc004edt.2	-	41	5154	c.4891A>T	c.(4891-4893)ACA>TCA	p.T1631S	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.T1227S|BRWD3_uc004edp.2_Missense_Mutation_p.T1460S|BRWD3_uc004edq.2_Missense_Mutation_p.T1227S|BRWD3_uc010nmj.1_Missense_Mutation_p.T1227S|BRWD3_uc004edr.2_Missense_Mutation_p.T1301S|BRWD3_uc004eds.2_Missense_Mutation_p.T1227S|BRWD3_uc004edu.2_Missense_Mutation_p.T1301S|BRWD3_uc004edv.2_Missense_Mutation_p.T1227S|BRWD3_uc004edw.2_Missense_Mutation_p.T1227S|BRWD3_uc004edx.2_Missense_Mutation_p.T1227S|BRWD3_uc004edy.2_Missense_Mutation_p.T1227S|BRWD3_uc004edz.2_Missense_Mutation_p.T1301S|BRWD3_uc004eea.2_Missense_Mutation_p.T1301S|BRWD3_uc004eeb.2_Missense_Mutation_p.T1227S|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1631										ovary(4)	4						TCTTGATCTGTTCTGGAAGTT	0.378													47	36					0	0	0	0	A	79932626	A	A	79932626	3	1	16	1	0	0	0	0	1	0	0	0	1531	1725	60	5	521	5	BRWD3	23	79932626	Missense_Mutation	SNP	T	TCGA-BA-6869-01A-11D-1870-08	5970362	79932626	75337934	528	3916											
PABPC5	140886	broad.mit.edu	37	chrX	90690743	90690743	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgccgtgatccggtgacccGcagccccctgggctatgggt	4	8	14	15	3	0	2	0	2	0	0	1	2	1	2	5	3	2	2	5	3	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:90690743G>T	uc004efg.2	+	2	607	c.167G>T	c.(166-168)CGC>CTC	p.R56L	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	56	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CCGGTGACCCGCAGCCCCCTG	0.532													9	5					5.68852e-11	6.98533e-11	1	0	T	90690743	T	T	90690743	3	4	16	1	0	0	0	0	1	0	0	0	11421	1087	38	3	169	3	PABPC5	23	90690743	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	10758117	90690743	64579817	529	3917											
PCDH11X	27328	broad.mit.edu	37	chrX	91132611	91132611	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctcttcatcaaagtgaaaGatgaaaatgacaatgctcca	16	10	7	8	0	3	4	2	3	1	1	4	4	4	4	1	0	2	2	1	0	5	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:91132611G>C	uc004efk.1	+	2	2217	c.1372G>C	c.(1372-1374)GAT>CAT	p.D458H	PCDH11X_uc004efl.1_Missense_Mutation_p.D458H|PCDH11X_uc004efo.1_Missense_Mutation_p.D458H|PCDH11X_uc010nmv.1_Missense_Mutation_p.D458H|PCDH11X_uc004efm.1_Missense_Mutation_p.D458H|PCDH11X_uc004efn.1_Missense_Mutation_p.D458H|PCDH11X_uc004efh.1_Missense_Mutation_p.D458H|PCDH11X_uc004efj.1_Missense_Mutation_p.D458H	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	458	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CAAAGTGAAAGATGAAAATGA	0.403													27	12					0	0	0	0	C	91132611	C	C	91132611	3	2	16	1	0	0	0	0	1	0	0	0	11562	942	33	2	1378	2	PCDH11X	23	91132611	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	441868	91132611	64137949	530	3918											
NXF3	56000	broad.mit.edu	37	chrX	102332651	102332651	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctggtatcccgcacaaagAgcttgtcattcacgatgcac	10	9	10	12	2	2	1	2	0	0	1	3	2	3	1	1	2	2	5	1	2	2	3			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:102332651A>T	uc004eju.2	-	18	1546	c.1475T>A	c.(1474-1476)CTC>CAC	p.L492H	NXF3_uc010noi.1_3'UTR	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	492	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CCGCACAAAGAGCTTGTCATT	0.572													42	22					0	0	0	0	T	102332651	T	T	102332651	3	4	16	1	0	0	0	0	1	0	0	0	10839	304	11	5	128	5	NXF3	23	102332651	Missense_Mutation	SNP	A	TCGA-BA-6869-01A-11D-1870-08	11200040	102332651	52937909	531	3919											
TEX13A	56157	broad.mit.edu	37	chrX	104464879	104464879	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaaggccaggctgccccagGtgcaggcctctttgacctca	7	7	11	16	0	2	1	1	1	1	0	2	1	2	1	6	4	2	2	6	4	1	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:104464879G>A	uc004ema.2	-	2	315	c.203C>T	c.(202-204)ACC>ATC	p.T68I	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.T68I	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	68						intracellular	zinc ion binding			ovary(2)	2						GCTGCCCCAGGTGCAGGCCTC	0.582													16	11					0	0	0	0	A	104464879	A	A	104464879	3	1	16	1	0	0	0	0	1	0	0	0	15842	1261	44	4	1036	4	TEX13A	23	104464879	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	2132228	104464879	50805681	532	3920											
NRK	203447	broad.mit.edu	37	chrX	105132386	105132386	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcatttttcaagctgagtCcccctggtcagcggcaccaa	9	9	10	13	1	2	1	2	1	0	0	3	2	3	1	3	2	3	3	3	2	2	2			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:105132386C>A	uc004emd.2	+	5	655	c.352C>A	c.(352-354)CCC>ACC	p.P118T	NRK_uc010npc.1_5'UTR	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	118	Protein kinase.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						CAAGCTGAGTCCCCCTGGTCA	0.398										HNSCC(51;0.14)			5	2					5.9392e-07	6.62092e-07	1	0	A	105132386	A	A	105132386	3	1	16	1	0	0	0	0	1	0	0	0	10709	855	30	2	370	2	NRK	23	105132386	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	667507	105132386	50138174	533	3921											
BCORL1	63035	broad.mit.edu	37	chrX	129184758	129184758	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcctgggatttttacagcaGttctgtgttgggtaagtttt	7	18	11	5	0	1	0	0	0	1	0	2	1	2	1	1	2	2	5	1	2	2	8			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:129184758G>T	uc004evb.1	+	11	4799	c.4685G>T	c.(4684-4686)AGT>ATT	p.S1562I	BCORL1_uc004evc.1_Missense_Mutation_p.S398I	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1562					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TTTTACAGCAGTTCTGTGTTG	0.502													61	39					8.33888e-18	1.13728e-17	1	0	T	129184758	T	T	129184758	3	4	16	1	0	0	0	0	1	0	0	0	1389	1029	36	4	4949	4	BCORL1	23	129184758	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	24052372	129184758	26085802	534	3922											
GPR101	83550	broad.mit.edu	37	chrX	136112905	136112905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccgtcgctggccaccgtgCtgctctctctgacctcctcg	2	11	10	18	4	2	1	0	1	2	0	6	1	3	1	5	1	3	3	5	1	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:136112905C>T	uc011mwh.1	-	1	929	c.929G>A	c.(928-930)AGC>AAC	p.S310N		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	310	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GGCCACCGTGCTGCTCTCTCT	0.602													72	51					0	0	0	0	T	136112905	T	T	136112905	3	4	16	1	0	0	0	0	1	0	0	0	6660	797	28	4	600	4	GPR101	23	136112905	Missense_Mutation	SNP	C	TCGA-BA-6869-01A-11D-1870-08	6928147	136112905	19157655	535	3923											
MAGEC1	9947	broad.mit.edu	37	chrX	140993368	140993368	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtcctcagagtcgttctgagGgggaggactcctcggatcct	6	10	14	11	2	2	2	1	1	1	1	7	5	5	5	3	4	0	1	3	4	0	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:140993368G>T	uc004fbt.2	+	4	464	c.178G>T	c.(178-180)GGG>TGG	p.G60W	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	60							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCGTTCTGAGGGGGAGGACTC	0.602										HNSCC(15;0.026)			42	31					4.67007e-22	6.60819e-22	1	0	T	140993368	T	T	140993368	3	4	16	1	0	0	0	0	1	0	0	0	9233	1232	43	4	184	4	MAGEC1	23	140993368	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4880463	140993368	14277192	536	3924											
PLXNA3	55558	broad.mit.edu	37	chrX	153689091	153689091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccgcaagctcatcagtgatGaagacagcgcggacatgttc	11	7	11	12	3	2	3	2	2	0	1	3	4	2	4	1	1	2	3	1	1	2	1			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:153689091G>A	uc004flm.2	+	2	741	c.568G>A	c.(568-570)GAA>AAA	p.E190K		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	190	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CATCAGTGATGAAGACAGCGC	0.597													29	18					0	0	0	0	A	153689091	A	A	153689091	3	1	16	1	0	0	0	0	1	0	0	0	12176	1291	45	2	570	2	PLXNA3	23	153689091	Missense_Mutation	SNP	G	TCGA-BA-6869-01A-11D-1870-08	12695723	153689091	1581469	537	3925											
PLXNA3	55558	broad.mit.edu	37	chrX	153693211	153693211	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagggtccacagccctgaGgtgaggcgggcgccgcatgt	6	5	18	12	3	0	2	0	2	0	0	1	2	1	2	3	5	1	2	3	5	0	0			TCGA-BA-6869-01A-11D-1870-08	TCGA-BA-6869-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	b78a2501-f312-41a2-ab19-7c18d8dfbac6	2db34c9d-a6f8-4a60-97c4-cf139a9415bb	g.chrX:153693211G>A	uc004flm.2	+	10	2216	c.2043G>A	c.(2041-2043)GAG>GAA	p.E681E		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	681	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACAGCCCTGAGGTGAGGCGGG	0.662													3	2					0	0	0	0	A	153693211	A	A	153693211	2	1	16	1	0	0	0	0	0	0	0	1	12176	1014	35	4		4	PLXNA3	23	153693211	Silent	SNP	G	TCGA-BA-6869-01A-11D-1870-08	4120	153693211	1577349	538	3926											
ZMYM6	9204	broad.mit.edu	37	chr1	35453123	35453123	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtccttccaggtgctcaaaaAtaatccttgtgatgtctgtc	9	14	8	10	0	2	1	1	1	1	0	6	1	5	1	3	1	1	1	3	1	3	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:35453123A>C	uc001byh.2	-	16	3788	c.3560T>G	c.(3559-3561)ATT>AGT	p.I1187S	uc001byd.3_5'Flank|uc001bye.2_5'Flank|ZMYM6_uc001byf.1_Intron|ZMYM6_uc010oht.1_Missense_Mutation_p.I1090S	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	1187					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GTGCTCAAAAATAATCCTTGT	0.299													9	63					0	0	0	0	C	35453123	C	C	35453123	3	2	17	1	0	0	0	0	1	0	0	0	17771	101	4	5	421	5	ZMYM6	1	35453123	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08		35453123	213797498	1	3927											
RLF	6018	broad.mit.edu	37	chr1	40703347	40703347	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccaaaaagataaagacgaaAgatctgtttccctctttggg	14	10	8	9	1	2	3	0	0	2	3	3	4	3	3	2	1	0	1	2	1	5	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:40703347A>G	uc001cfc.3	+	8	3004	c.2973A>G	c.(2971-2973)AAA>AAG	p.K991K	RLF_uc001cfd.3_Silent_p.K682K	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	991					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TAAAGACGAAAGATCTGTTTC	0.408													14	43					0	0	0	0	G	40703347	G	G	40703347	2	3	17	1	0	0	0	0	0	0	0	1	13454	69	3	5		5	RLF	1	40703347	Silent	SNP	A	TCGA-BA-6870-01A-11D-1870-08	5250224	40703347	208547274	2	3928											
ERMAP	114625	broad.mit.edu	37	chr1	43305715	43305715	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attctttagagaaactccggAgtgaactgagtaagtttccc	12	12	9	8	1	1	3	0	2	1	1	3	5	3	4	2	1	2	2	2	1	4	5			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:43305715A>T	uc001cic.1	+	9	919	c.649A>T	c.(649-651)AGT>TGT	p.S217C	ERMAP_uc001cid.1_RNA|ERMAP_uc001cie.1_Missense_Mutation_p.S217C|ERMAP_uc001cif.1_Missense_Mutation_p.S127C	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	217	Cytoplasmic (Potential).		Missing (in Sc-3 allele).			integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAAACTCCGGAGTGAACTGAG	0.438													45	129					0	0	0	0	T	43305715	T	T	43305715	3	4	17	1	0	0	0	0	1	0	0	0	5258	304	11	5	675	5	ERMAP	1	43305715	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	2602368	43305715	205944906	3	3929											
CYP4A22	284541	broad.mit.edu	37	chr1	47609524	47609535	+	In_Frame_Del	DEL	CTACAGCCTGAC	-	-																															tttcatgagaatgacaccatCtacagcctgacctctgctgg																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:47609524_47609535delCTACAGCCTGAC	uc001cqv.1	+	6	777_788	c.726_737delCTACAGCCTGAC	c.(724-738)ATCTACAGCCTGACC>ATC	p.YSLT243del	CYP4A22_uc009vyo.2_In_Frame_Del_p.YSLT243del|CYP4A22_uc009vyp.2_Intron	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	243_246						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						ATGACACCATCTACAGCCTGACCTCTGCTGGC	0.542													---	---	---								-	47609535	-	-	47609524	7	5	17	1	0	1	0	1	0	0	0	0	4201	903	32	0	748	0	CYP4A22	1	47609524	In_Frame_Del	DEL	CTACAGCCTGAC	TCGA-BA-6870-01A-11D-1870-08	4303809	47609524	201641097	4	3930											
ANKRD13C	81573	broad.mit.edu	37	chr1	70758091	70758091	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaaaattctgttccattaTgtttccacctttactcaaac	11	16	2	12	0	3	0	2	0	1	0	5	0	5	0	3	0	2	2	3	0	5	6			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:70758091T>G	uc001dex.3	-	9	1521	c.1195A>C	c.(1195-1197)ATA>CTA	p.I399L	ANKRD13C_uc009wbk.2_Missense_Mutation_p.I364L	NM_030816	NP_110443	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	399					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding				0						TGTTCCATTATGTTTCCACCT	0.338													15	57					0	0	0	0	G	70758091	G	G	70758091	3	3	17	1	0	0	0	0	1	0	0	0	643	1464	51	5	450	5	ANKRD13C	1	70758091	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08	23148567	70758091	178492530	5	3931											
CASQ2	845	broad.mit.edu	37	chr1	116280931	116280931	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacttccagtttgctgctgAtgatctccactgggtcttca	6	14	10	11	0	3	2	1	2	2	0	5	3	4	3	2	2	2	3	2	2	0	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:116280931A>C	uc001efx.3	-	4	710	c.446T>G	c.(445-447)ATC>AGC	p.I149S	CASQ2_uc010owu.1_Intron	NM_001232	NP_001223	O14958	CASQ2_HUMAN	cardiac calsequestrin 2 precursor	149					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTTGCTGCTGATGATCTCCAC	0.443													47	121					0	0	0	0	C	116280931	C	C	116280931	3	2	17	1	0	0	0	0	1	0	0	0	2693	333	12	5	785	5	CASQ2	1	116280931	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	45522840	116280931	132969690	6	3932											
NOTCH2	4853	broad.mit.edu	37	chr1	120502074	120502074	+	Frame_Shift_Del	DEL	T	-	-																															tgccatccatacagattccaTggatacaagggttacttgca																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:120502074delT	uc001eik.2	-	12	2223	c.1967delA	c.(1966-1968)CATfs	p.H656fs	NOTCH2_uc001eil.2_Frame_Shift_Del_p.H656fs|NOTCH2_uc001eim.3_Frame_Shift_Del_p.H573fs	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	656	Extracellular (Potential).|EGF-like 17; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGATTCCATGGATACAAGG	0.428			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				---	---	---								-	120502074	-	-	120502074	7	5	17	1	0	1	0	1	0	0	0	0	10602	1464	51	0	5540	0	NOTCH2	1	120502074	Frame_Shift_Del	DEL	T	TCGA-BA-6870-01A-11D-1870-08	4221143	120502074	128748547	7	3933											
ZNF687	57592	broad.mit.edu	37	chr1	151259824	151259824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	taactcaggtcccctcagatCctgatccacctgcccccttg	7	10	6	18	0	2	2	2	1	0	1	5	2	5	2	7	1	2	0	7	1	1	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:151259824C>T	uc001exq.2	+	2	1155	c.1057C>T	c.(1057-1059)CCT>TCT	p.P353S	ZNF687_uc001exp.1_Missense_Mutation_p.P362S|ZNF687_uc009wmo.2_Missense_Mutation_p.P353S|ZNF687_uc009wmp.2_Missense_Mutation_p.P353S	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCCCTCAGATCCTGATCCACC	0.562													29	65					0	0	0	0	T	151259824	T	T	151259824	3	4	17	1	0	0	0	0	1	0	0	0	18159	855	30	2	1059	2	ZNF687	1	151259824	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	30757750	151259824	97990797	8	3934											
ADAM15	8751	broad.mit.edu	37	chr1	155034393	155034393	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcaggctgagctggctgAccgacccaatccccctaccc	7	8	9	17	1	1	2	1	2	0	0	2	3	2	2	5	2	2	4	5	2	2	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:155034393A>G	uc001fgr.1	+	21	2467	c.2366A>G	c.(2365-2367)GAC>GGC	p.D789G	EFNA3_uc010pew.1_5'Flank|ADAM15_uc001fgq.1_Missense_Mutation_p.D473G|ADAM15_uc001fgt.1_Missense_Mutation_p.D788G|ADAM15_uc010pev.1_Intron|ADAM15_uc001fgs.1_Intron|ADAM15_uc001fgu.1_Missense_Mutation_p.D764G|ADAM15_uc001fgw.1_Intron|ADAM15_uc001fgv.1_Intron|ADAM15_uc001fgx.1_Intron|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_Intron|EFNA4_uc001fhc.2_5'Flank|EFNA4_uc001fhd.2_5'Flank|EFNA4_uc001fhe.2_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	789	Cytoplasmic (Potential).				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GAGCTGGCTGACCGACCCAAT	0.642											OREG0013848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	145					0	0	0	0	G	155034393	G	G	155034393	3	3	17	1	0	0	0	0	1	0	0	0	237	275	10	5	2448	5	ADAM15	1	155034393	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	3774569	155034393	94216228	9	3935											
BCAN	63827	broad.mit.edu	37	chr1	156618415	156618415	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acattggaggaagcacgggcGtactgccaggagcggggtgc	9	5	18	9	3	0	0	0	0	0	0	0	3	0	3	1	6	5	2	1	6	2	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:156618415G>A	uc001fpp.2	+	6	1161	c.825G>A	c.(823-825)GCG>GCA	p.A275A	BCAN_uc001fpo.2_Silent_p.A275A	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	275	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AAGCACGGGCGTACTGCCAGG	0.498													24	126					0	0	0	0	A	156618415	A	A	156618415	2	1	17	1	0	0	0	0	0	0	0	1	1347	1132	40	1		1	BCAN	1	156618415	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08	1584022	156618415	92632206	10	3936											
CFH	3075	broad.mit.edu	37	chr1	196658702	196658702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagttactgggatcacattCattgcacacaagatggatgg	13	10	11	7	0	2	1	2	0	0	1	2	4	2	3	0	3	2	2	0	3	3	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:196658702C>T	uc001gtj.3	+	8	1357	c.1117C>T	c.(1117-1119)CAT>TAT	p.H373Y	CFH_uc001gti.3_Missense_Mutation_p.H373Y|CFH_uc009wyw.2_Missense_Mutation_p.H348Y|CFH_uc009wyx.2_Missense_Mutation_p.H309Y	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	373	Sushi 6.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GGATCACATTCATTGCACACA	0.393													9	130					0	0	0	0	T	196658702	T	T	196658702	3	4	17	1	0	0	0	0	1	0	0	0	3298	826	29	2	1147	2	CFH	1	196658702	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	40040287	196658702	52591919	11	3937											
URB2	9816	broad.mit.edu	37	chr1	229773396	229773396	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggagctaatgcagatgctCatccaaatgaagctgagctt	13	9	11	8	0	1	3	1	2	0	1	2	5	2	4	1	1	5	5	1	1	3	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:229773396C>A	uc001hts.1	+	4	3172	c.3036C>A	c.(3034-3036)CTC>CTA	p.L1012L	URB2_uc009xfd.1_Silent_p.L1012L	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1012						nucleolus				central_nervous_system(2)|ovary(1)	3						TGCAGATGCTCATCCAAATGA	0.448													26	49					1.64293e-13	1.99609e-13	1	0	A	229773396	A	A	229773396	2	1	17	1	0	0	0	0	0	0	0	1	17093	813	29	2		2	URB2	1	229773396	Silent	SNP	C	TCGA-BA-6870-01A-11D-1870-08	33114694	229773396	19477225	12	3938											
OR2C3	81472	broad.mit.edu	37	chr1	247695697	247695697	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atgatgccattgcccaagatCgataccatgtaaaaactcaa	16	9	6	10	1	1	2	1	1	0	1	2	3	1	2	3	0	4	1	3	0	6	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr1:247695697C>G	uc009xgy.2	-	2	479	c.117G>C	c.(115-117)TCG>TCC	p.S39S	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TGCCCAAGATCGATACCATGT	0.473													25	109					0	0	0	0	G	247695697	G	G	247695697	2	3	17	1	0	0	0	0	0	0	0	1	11047	871	31	3		3	OR2C3	1	247695697	Silent	SNP	C	TCGA-BA-6870-01A-11D-1870-08	17922301	247695697	1554924	13	3939											
HADHA	3030	broad.mit.edu	37	chr2	26415267	26415267	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcacaccctcctgatagaTgtaaaagcccttcccagatt	11	11	5	14	0	1	3	1	1	0	2	3	3	3	3	4	0	1	1	4	0	3	5			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:26415267T>C	uc002rgy.2	-	18	2042	c.1912A>G	c.(1912-1914)ATC>GTC	p.I638V	HADHA_uc010yks.1_Missense_Mutation_p.I551V	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	638					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	TCCTGATAGATGTAAAAGCCC	0.428													15	49					0	0	0	0	C	26415267	C	C	26415267	3	2	17	1	0	0	0	0	1	0	0	0	6982	1464	51	5	391	5	HADHA	2	26415267	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08		26415267	216784106	14	3940											
CCDC88A	55704	broad.mit.edu	37	chr2	55573405	55573405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgactctgactgctttctctCgaagtgcatctaattcatct	8	15	6	12	2	5	1	1	1	4	0	7	3	5	1	0	0	2	2	0	0	2	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:55573405C>T	uc002ryv.2	-	10	1789	c.947G>A	c.(946-948)CGA>CAA	p.R316Q	CCDC88A_uc010yoz.1_Missense_Mutation_p.R316Q|CCDC88A_uc010ypa.1_Missense_Mutation_p.R316Q|CCDC88A_uc010ypb.1_Missense_Mutation_p.R218Q	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	316	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TGCTTTCTCTCGAAGTGCATC	0.333													30	93					0	0	0	0	T	55573405	T	T	55573405	3	4	17	1	0	0	0	0	1	0	0	0	2876	884	31	1	4760	1	CCDC88A	2	55573405	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	29158138	55573405	187625968	15	3941											
MERTK	10461	broad.mit.edu	37	chr2	112732906	112732906	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagtaatggctcagtcatgaTttttaacacctctgccttac	10	14	7	10	0	3	1	2	1	1	0	3	2	3	1	2	1	3	2	2	1	3	5			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:112732906T>C	uc002thk.1	+	7	1123	c.1001T>C	c.(1000-1002)ATT>ACT	p.I334T	MERTK_uc002thl.1_Missense_Mutation_p.I158T	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	334	Fibronectin type-III 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						TCAGTCATGATTTTTAACACC	0.473													54	166					0	0	0	0	C	112732906	C	C	112732906	3	2	17	1	0	0	0	0	1	0	0	0	9532	1493	52	5	1027	5	MERTK	2	112732906	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08	57159501	112732906	130466467	16	3942											
MYO7B	4648	broad.mit.edu	37	chr2	128390861	128390861	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggaagcagcccccgcacCaggtggaggtggaggccgca	8	2	16	15	3	0	0	0	0	0	0	0	3	0	3	5	6	2	3	5	6	1	0			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:128390861C>A	uc002top.2	+	39	5409	c.5356C>A	c.(5356-5358)CAG>AAG	p.Q1786K	MYO7B_uc002tos.1_5'Flank|MYO7B_uc002tot.2_5'Flank	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1786	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GCCCCCGCACCAGGTGGAGGT	0.667													4	24					0.000602214	0.000669127	1	0	A	128390861	A	A	128390861	3	1	17	1	0	0	0	0	1	0	0	0	10136	595	21	4	5506	4	MYO7B	2	128390861	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	15657955	128390861	114808512	17	3943											
LRP1B	53353	broad.mit.edu	37	chr2	141457953	141457953	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagccaaggctatgacattcTtgaaataacgtggattctca	14	11	8	8	1	2	2	1	2	2	0	3	3	2	3	1	2	2	1	1	2	5	5			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:141457953T>C	uc002tvj.1	-	41	7637	c.6665A>G	c.(6664-6666)AAG>AGG	p.K2222R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2222	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATGACATTCTTGAAATAACG	0.318										TSP Lung(27;0.18)			35	143					0	0	0	0	C	141457953	C	C	141457953	3	2	17	1	0	0	0	0	1	0	0	0	9005	1609	56	5	7338	5	LRP1B	2	141457953	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08	13067092	141457953	101741420	18	3944											
ASNSD1	54529	broad.mit.edu	37	chr2	190532561	190532561	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catcgtgtccgctttcagtcGcatgggctggaaggattgaa	8	11	13	9	3	1	1	1	1	0	0	4	3	2	3	1	3	0	3	1	3	2	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr2:190532561G>A	uc002uqt.2	+	5	1970	c.1536G>A	c.(1534-1536)TCG>TCA	p.S512S		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	512	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			GCTTTCAGTCGCATGGGCTGG	0.413													4	142					0	0	0	0	A	190532561	A	A	190532561	2	1	17	1	0	0	0	0	0	0	0	1	1051	1074	38	1		1	ASNSD1	2	190532561	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08	49074608	190532561	52666812	19	3945											
PTPN23	25930	broad.mit.edu	37	chr3	47450918	47450918	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttcctcagaagttgttcgaGgagcagctgaaaaagtatga	13	10	11	7	1	1	3	1	2	0	1	3	5	2	4	1	1	2	5	1	1	4	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr3:47450918G>A	uc003crf.1	+	18	1905	c.1809G>A	c.(1807-1809)GAG>GAA	p.E603E	PTPN23_uc011baw.1_Silent_p.E568E|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Silent_p.E473E	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	603	Potential.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGTTGTTCGAGGAGCAGCTGA	0.622													3	39					0	0	0	0	A	47450918	A	A	47450918	2	1	17	1	0	0	0	0	0	0	0	1	12853	991	35	4		4	PTPN23	3	47450918	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08		47450918	150571512	20	3946											
OR5H1	26341	broad.mit.edu	37	chr3	97852161	97852161	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattttctcaggttcaattcAggtattcagcattgtgacta	10	17	7	7	0	4	1	4	1	1	0	5	1	4	1	0	2	1	3	0	2	4	9			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr3:97852161A>G	uc011bgt.1	+	1	620	c.620A>G	c.(619-621)CAG>CGG	p.Q207R		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GGTTCAATTCAGGTATTCAGC	0.318													3	83					0	0	0	0	G	97852161	G	G	97852161	3	3	17	1	0	0	0	0	1	0	0	0	11213	188	7	5	622	5	OR5H1	3	97852161	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	50401243	97852161	100170269	21	3947											
TRH	7200	broad.mit.edu	37	chr3	129695840	129695840	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaaggagctgggaagaagaGgaggaggaggaagagagaga	18	1	20	2	0	0	4	0	0	0	4	0	12	0	10	0	6	1	1	0	6	4	0			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr3:129695840G>A	uc003enc.2	+	3	1071	c.510G>A	c.(508-510)GAG>GAA	p.E170E		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	170					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						Gggaagaagaggaggaggagg	0.547													3	78					0	0	0	0	A	129695840	A	A	129695840	2	1	17	1	0	0	0	0	0	0	0	1	16545	991	35	4		4	TRH	3	129695840	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08	31843679	129695840	68326590	22	3948											
NCK1	4690	broad.mit.edu	37	chr3	136665013	136665013	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtgattacattaggccttCactcactggaaagtttgctg	9	14	10	8	0	2	1	2	1	0	0	2	2	2	2	1	2	2	2	1	2	3	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr3:136665013C>T	uc003erh.2	+	3	922	c.815C>T	c.(814-816)TCA>TTA	p.S272L	NCK1_uc011bme.1_Missense_Mutation_p.S208L	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	272					axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1						ATTAGGCCTTCACTCACTGGA	0.413													28	161					0	0	0	0	T	136665013	T	T	136665013	3	4	17	1	0	0	0	0	1	0	0	0	10273	838	29	2	821	2	NCK1	3	136665013	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	6969173	136665013	61357417	23	3949											
PACRGL	133015	broad.mit.edu	37	chr4	20706289	20706289	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgtttttttccaggtaactAtgatcaaaggacatcatcaa	13	14	6	8	0	3	1	3	1	0	0	4	2	4	2	1	2	1	2	1	2	4	5			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr4:20706289A>G	uc010iek.2	+	3	450	c.59A>G	c.(58-60)TAT>TGT	p.Y20C	PACRGL_uc003gpu.2_RNA|PACRGL_uc010iei.1_Missense_Mutation_p.Y68C|PACRGL_uc003gpz.2_Missense_Mutation_p.Y20C|PACRGL_uc011bxm.1_Missense_Mutation_p.Y20C|PACRGL_uc003gqa.2_Missense_Mutation_p.Y20C|PACRGL_uc003gpx.3_RNA|PACRGL_uc003gpv.2_Missense_Mutation_p.Y20C|PACRGL_uc003gpw.2_RNA|PACRGL_uc010iej.1_RNA|PACRGL_uc011bxn.1_Missense_Mutation_p.Y20C|PACRGL_uc003gpy.2_Missense_Mutation_p.Y20C	NM_145048	NP_659485	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like isoform 1	20							binding				0						CCAGGTAACTATGATCAAAGG	0.403													12	40					0	0	0	0	G	20706289	G	G	20706289	3	3	17	1	0	0	0	0	1	0	0	0	11425	449	16	5	65	5	PACRGL	4	20706289	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08		20706289	170447987	24	3950											
GNRHR	2798	broad.mit.edu	37	chr4	68606303	68606303	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaacctgtttaacatttcAggatcaaaccaataccaaat	17	10	4	10	0	2	0	2	0	0	0	2	2	2	1	3	1	4	1	3	1	6	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr4:68606303A>T	uc003hdn.2	-	3	2633	c.882T>A	c.(880-882)CCT>CCA	p.P294P	LOC550112_uc003hdl.3_Intron|GNRHR_uc003hdm.2_3'UTR|uc003hdo.1_5'Flank	NM_000406	NP_000397	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor isoform	294	Helical; Name=6; (Potential).				multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			ovary(1)	1					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	TTAACATTTCAGGATCAAACC	0.393													4	259					0	0	0	0	T	68606303	T	T	68606303	2	4	17	1	0	0	0	0	0	0	0	1	6586	175	7	5		5	GNRHR	4	68606303	Silent	SNP	A	TCGA-BA-6870-01A-11D-1870-08	47900014	68606303	122547973	25	3951											
NDST4	64579	broad.mit.edu	37	chr4	115997541	115997541	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttggaaaatagtccagtcttCcccaggaagagggcctttct	10	11	10	10	0	2	1	0	0	2	1	4	3	4	3	4	3	0	0	4	3	4	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr4:115997541C>T	uc003ibu.2	-	2	1331	c.652G>A	c.(652-654)GAA>AAA	p.E218K	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	218	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GTCCAGTCTTCCCCAGGAAGA	0.408													19	62					0	0	0	0	T	115997541	T	T	115997541	3	4	17	1	0	0	0	0	1	0	0	0	10312	864	30	2	2018	2	NDST4	4	115997541	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	47391238	115997541	75156735	26	3952											
TBC1D9	23158	broad.mit.edu	37	chr4	141591978	141591978	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctctgcactagaaagtctcTatctttcaagttggcaaata	12	13	6	10	0	4	1	1	0	3	1	5	1	4	1	1	1	1	3	1	1	6	5			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr4:141591978T>C	uc010ioj.2	-	7	1434	c.1162A>G	c.(1162-1164)AGA>GGA	p.R388G		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	388						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				AGAAAGTCTCTATCTTTCAAG	0.443													49	117					0	0	0	0	C	141591978	C	C	141591978	3	2	17	1	0	0	0	0	1	0	0	0	15693	1530	53	5	2698	5	TBC1D9	4	141591978	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08	25594437	141591978	49562298	27	3953											
C4orf41	60684	broad.mit.edu	37	chr4	184596347	184596347	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaggcatcagttcaaaataGctttcttcagtgagttgaaa	13	14	8	6	0	4	2	3	2	1	0	4	2	4	2	0	1	1	4	0	1	5	6			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr4:184596347G>A	uc003ivx.2	+	7	867	c.691G>A	c.(691-693)GCT>ACT	p.A231T	C4orf41_uc003ivw.2_Missense_Mutation_p.A231T|C4orf41_uc010isc.2_Intron	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	231											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		GTTCAAAATAGCTTTCTTCAG	0.239													5	40					0	0	0	0	A	184596347	A	A	184596347	3	1	17	1	0	0	0	0	1	0	0	0	2280	971	34	4	713	4	C4orf41	4	184596347	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	43004369	184596347	6557929	28	3954											
CDH9	1007	broad.mit.edu	37	chr5	26915954	26915954	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtctcctgtattttcatctaTaacaaatagactgccagccc	11	13	5	12	0	3	1	1	0	2	1	4	1	3	1	3	0	3	1	3	0	5	6			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:26915954T>C	uc003jgs.1	-	3	476	c.307A>G	c.(307-309)ATA>GTA	p.I103V	CDH9_uc010iug.2_Missense_Mutation_p.I103V	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	103	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTTTCATCTATAACAAATAGA	0.378													95	152					0	0	0	0	C	26915954	C	C	26915954	3	2	17	1	0	0	0	0	1	0	0	0	3132	1406	49	5	2102	5	CDH9	5	26915954	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08		26915954	153999306	29	3955											
CDH6	1004	broad.mit.edu	37	chr5	31302316	31302316	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggagaaaatgctgaaattGagtacagcatcacagacggt	15	8	12	6	1	1	4	1	2	0	2	1	5	1	4	0	2	3	3	0	2	4	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:31302316G>C	uc003jhe.1	+	6	1236	c.910G>C	c.(910-912)GAG>CAG	p.E304Q	CDH6_uc003jhd.1_Missense_Mutation_p.E304Q	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	304	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TGCTGAAATTGAGTACAGCAT	0.473													11	105					0	0	0	0	C	31302316	C	C	31302316	3	2	17	1	0	0	0	0	1	0	0	0	3129	1291	45	2	928	2	CDH6	5	31302316	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	4386362	31302316	149612944	30	3956											
GHR	2690	broad.mit.edu	37	chr5	42718796	42718796	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgaacctgacattctggAgactgatttcaatgccaatg	11	13	9	8	0	2	4	1	3	1	1	2	5	2	4	2	1	2	0	2	1	3	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:42718796A>G	uc003jmt.2	+	10	1230	c.1187A>G	c.(1186-1188)GAG>GGG	p.E396G	GHR_uc011cpq.1_Missense_Mutation_p.E209G	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	396	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GACATTCTGGAGACTGATTTC	0.478													23	96					0	0	0	0	G	42718796	G	G	42718796	3	3	17	1	0	0	0	0	1	0	0	0	6408	304	11	5	1221	5	GHR	5	42718796	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	11416480	42718796	138196464	31	3957											
SKIV2L2	23517	broad.mit.edu	37	chr5	54662572	54662572	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggctccgctgatcctctaaAtagtgctttccatttgacct	7	14	8	12	1	1	2	0	2	1	0	4	2	4	2	4	1	1	3	4	1	3	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:54662572A>G	uc003jpy.3	+	16	1945	c.1679A>G	c.(1678-1680)AAT>AGT	p.N560S	SKIV2L2_uc011cqi.1_Missense_Mutation_p.N459S	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	560	Helicase C-terminal.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				GATCCTCTAAATAGTGCTTTC	0.338													31	63					0	0	0	0	G	54662572	G	G	54662572	3	3	17	1	0	0	0	0	1	0	0	0	14425	101	4	5	1741	5	SKIV2L2	5	54662572	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	11943776	54662572	126252688	32	3958											
CMYA5	202333	broad.mit.edu	37	chr5	79032587	79032587	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaaagtcaagcagagatatgCcagatcacagtgaagaaaaa	21	5	9	6	0	2	4	2	1	0	3	2	5	2	4	1	0	2	1	1	0	7	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:79032587C>G	uc003kgc.2	+	2	8071	c.7999C>G	c.(7999-8001)CCA>GCA	p.P2667A		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2667						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CAGAGATATGCCAGATCACAG	0.403													10	46					0	0	0	0	G	79032587	G	G	79032587	3	3	17	1	0	0	0	0	1	0	0	0	3605	739	26	4	8005	4	CMYA5	5	79032587	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	24370015	79032587	101882673	33	3959											
TCF7	6932	broad.mit.edu	37	chr5	133477960	133477961	+	Frame_Shift_Ins	INS	-	GG	GG																															cggccattgtgcccccctcaINSgggaagcaggagctgcagcc																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:133477960_133477961insGG	uc003kyt.2	+	6	916_917	c.720_721insGG	c.(718-723)TCAGGGfs	p.S240fs	TCF7_uc003kyu.1_Frame_Shift_Ins_p.S125fs|TCF7_uc003kyv.2_Frame_Shift_Ins_p.S125fs|TCF7_uc003kyw.2_Frame_Shift_Ins_p.S125fs|TCF7_uc003kyx.2_Frame_Shift_Ins_p.S38fs|TCF7_uc003kyy.2_Frame_Shift_Ins_p.S125fs|TCF7_uc003kyz.2_Frame_Shift_Ins_p.S125fs|TCF7_uc003kza.2_Frame_Shift_Ins_p.S125fs|TCF7_uc003kzb.2_Frame_Shift_Ins_p.S54fs|TCF7_uc010jdu.2_5'Flank	NM_003202	NP_003193	P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific,	240_241					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding				0		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGCCCCCCTCAGGGAAGCAGGA	0.604													---	---	---								GG	133477961	GG	GG	133477960	7	5	17	1	0	1	1	0	0	0	0	0	15762	175	7	0	742	0	TCF7	5	133477960	Frame_Shift_Ins	INS	-	TCGA-BA-6870-01A-11D-1870-08	54445373	133477960	47437300	34	3960											
PCDHA5	56143	broad.mit.edu	37	chr5	140202875	140202875	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcgagcgcccgctgtcgagTtacgtttcggtgcacgcgga	5	8	16	12	8	0	0	0	0	0	0	2	3	0	1	1	3	3	4	1	3	1	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:140202875T>C	uc003lhl.2	+	1	1515	c.1515T>C	c.(1513-1515)AGT>AGC	p.S505S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.S505S|PCDHA5_uc003lhj.1_Silent_p.S505S	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	505	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGTCGAGTTACGTTTCGG	0.682													25	86					0	0	0	0	C	140202875	C	C	140202875	2	2	17	1	0	0	0	0	0	0	0	1	11581	1722	60	5		5	PCDHA5	5	140202875	Silent	SNP	T	TCGA-BA-6870-01A-11D-1870-08	6724915	140202875	40712385	35	3961											
PCDHB12	56124	broad.mit.edu	37	chr5	140588971	140588971	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggatttagatgtaggaatCaatgctgtaaaaagctacac	17	10	9	5	0	1	1	1	0	0	1	1	3	1	3	0	2	3	4	0	2	9	5			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:140588971C>A	uc003liz.2	+	1	681	c.492C>A	c.(490-492)ATC>ATA	p.I164I	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	164	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGTAGGAATCAATGCTGTAA	0.388													11	64					0.000673444	0.00074193	1	0	A	140588971	A	A	140588971	2	1	17	1	0	0	0	0	0	0	0	1	11591	816	29	2		2	PCDHB12	5	140588971	Silent	SNP	C	TCGA-BA-6870-01A-11D-1870-08	386096	140588971	40326289	36	3962											
PCDHGA6	56109	broad.mit.edu	37	chr5	140755399	140755399	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcgccccgctccgcagaGcccggctacctggtgaccaa	6	5	12	18	4	0	2	0	1	0	1	1	2	1	2	6	3	2	3	6	3	2	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:140755399G>A	uc003ljy.1	+	1	1749	c.1749G>A	c.(1747-1749)GAG>GAA	p.E583E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.E583E	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	583	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCCGCAGAGCCCGGCTACC	0.657													53	143					0	0	0	0	A	140755399	A	A	140755399	2	1	17	1	0	0	0	0	0	0	0	1	11612	962	34	4		4	PCDHGA6	5	140755399	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08	166428	140755399	40159861	37	3963											
DOCK2	1794	broad.mit.edu	37	chr5	169506012	169506012	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttagcatcacccaagacgccGagagtggagcaggaggaacc	13	4	13	11	2	1	2	1	0	0	2	1	6	1	5	3	3	3	2	3	3	3	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr5:169506012G>A	uc003maf.2	+	49	5108	c.5028G>A	c.(5026-5028)CCG>CCA	p.P1676P	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.P1168P|DOCK2_uc003mah.2_Silent_p.P232P	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1676					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCAAGACGCCGAGAGTGGAGC	0.547													16	141					0	0	0	0	A	169506012	A	A	169506012	2	1	17	1	0	0	0	0	0	0	0	1	4709	1045	37	1		1	DOCK2	5	169506012	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08	28750613	169506012	11409248	38	3964											
BAT2	7916	broad.mit.edu	37	chr6	31605291	31605291	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagggccgccacctcgagaAgggccctcccgacgggcaga	9	2	14	16	4	0	2	0	0	0	2	2	4	1	2	5	3	0	1	5	3	1	0			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:31605291A>G	uc003nvb.3	+	31	6651	c.6402A>G	c.(6400-6402)GAA>GAG	p.E2134E	BAT2_uc003nvc.3_Silent_p.E2134E	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	2134						cytoplasm|nucleus	protein binding				0						CACCTCGAGAAGGGCCCTCCC	0.677													28	100					0	0	0	0	G	31605291	G	G	31605291	2	3	17	1	0	0	0	0	0	0	0	1	1321	69	3	5		5	BAT2	6	31605291	Silent	SNP	A	TCGA-BA-6870-01A-11D-1870-08		31605291	139509776	39	3965											
BAT3	7917	broad.mit.edu	37	chr6	31610753	31610754	+	Frame_Shift_Ins	INS	-	A	A																															gagagaactgaagatcagccINSatggagggttgaggggtggg																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:31610753_31610754insA	uc003nvg.3	-	14	2119_2120	c.1805_1806insT	c.(1804-1806)ATGfs	p.M602fs	BAT3_uc003nvf.3_Frame_Shift_Ins_p.M596fs|BAT3_uc003nvh.3_Frame_Shift_Ins_p.M596fs|BAT3_uc003nvi.3_Frame_Shift_Ins_p.M596fs|BAT3_uc011dnw.1_Frame_Shift_Ins_p.M596fs|BAT3_uc011dnx.1_Intron	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	602	3.|4 X 29 AA approximate repeats.|Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						GAAGATCAGCCATGGAGGGTTG	0.653													---	---	---								A	31610754	A	A	31610753	7	5	17	1	0	1	1	0	0	0	0	0	1324	594	21	0	1640	0	BAT3	6	31610753	Frame_Shift_Ins	INS	-	TCGA-BA-6870-01A-11D-1870-08	5462	31610753	139504314	40	3966											
TREML2	79865	broad.mit.edu	37	chr6	41166046	41166046	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaggctcacacttcttcttCctgattttgcaccaaacctt	8	14	4	15	0	3	1	1	1	2	0	4	1	4	1	4	1	2	2	4	1	1	6			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:41166046C>A	uc010jxm.1	-	2	356	c.177G>T	c.(175-177)AGG>AGT	p.R59S		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	59	Ig-like V-type.|Extracellular (Potential).			R -> K (in Ref. 3; BAB14668).	T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					ACTTCTTCTTCCTGATTTTGC	0.552													47	148					6.31075e-24	7.96503e-24	1	0	A	41166046	A	A	41166046	3	1	17	1	0	0	0	0	1	0	0	0	16540	854	30	2	804	2	TREML2	6	41166046	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	9555293	41166046	129949021	41	3967											
OGFRL1	79627	broad.mit.edu	37	chr6	72003291	72003291	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caatcttcgtttttataagaAtaaaattccattcaagccag	15	14	4	8	1	2	1	1	0	1	1	4	1	3	1	2	0	1	1	2	0	7	8			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:72003291A>G	uc003pfx.1	+	3	540	c.377A>G	c.(376-378)AAT>AGT	p.N126S		NM_024576	NP_078852	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	126						membrane	receptor activity				0						TTTTATAAGAATAAAATTCCA	0.299													8	40					0	0	0	0	G	72003291	G	G	72003291	3	3	17	1	0	0	0	0	1	0	0	0	10898	101	4	5	387	5	OGFRL1	6	72003291	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	30837245	72003291	99111776	42	3968											
EEF1A1	1915	broad.mit.edu	37	chr6	74229664	74229664	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtcgatgccaccgcatttaTagatcagatggccagtagtg	10	11	11	9	2	1	2	1	0	0	2	2	3	1	2	3	1	1	2	3	1	3	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:74229664T>C	uc003phi.2	-	1	123	c.86A>G	c.(85-87)TAT>TGT	p.Y29C	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phf.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phg.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phh.2_5'UTR|EEF1A1_uc003phj.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phk.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phl.2_Missense_Mutation_p.Y29C|EEF1A1_uc003phm.1_RNA	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	29						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						ACCGCATTTATAGATCAGATG	0.418													15	81					0	0	0	0	C	74229664	C	C	74229664	3	2	17	1	0	0	0	0	1	0	0	0	4945	1406	49	5	1330	5	EEF1A1	6	74229664	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08	2226373	74229664	96885403	43	3969											
MED23	9439	broad.mit.edu	37	chr6	131926435	131926435	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttcataggtaagggggtaaTagatcctgaagccatacagt	13	10	12	6	0	1	2	1	1	0	1	2	2	2	2	2	3	2	3	2	3	6	6			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr6:131926435T>C	uc003qcs.1	-	14	1732	c.1558A>G	c.(1558-1560)ATT>GTT	p.I520V	MED23_uc003qcq.2_Missense_Mutation_p.I526V|MED23_uc011eca.1_Missense_Mutation_p.I161V|MED23_uc003qct.1_Missense_Mutation_p.I526V|MED23_uc011ecb.1_Intron	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	520					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		AAGGGGGTAATAGATCCTGAA	0.393													10	47					0	0	0	0	C	131926435	C	C	131926435	3	2	17	1	0	0	0	0	1	0	0	0	9494	1406	49	5	2619	5	MED23	6	131926435	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08	57696771	131926435	39188632	44	3970											
SBDS	51119	broad.mit.edu	37	chr7	66453484	66453484	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagcccgggtcaatcagacaTacctgaaacatttaacgtag	14	8	8	11	2	2	2	2	1	0	1	2	2	2	2	2	1	4	1	2	1	5	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:66453484T>C	uc003tvm.1	-	5	811	c.627A>G	c.(625-627)GTA>GTG	p.V209V		NM_016038	NP_057122	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome protein	209					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1						CAATCAGACATACCTGAAACA	0.408			Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				12	47					0	0	0	0	C	66453484	C	C	66453484	2	2	17	1	0	0	0	0	0	0	0	1	13922	1393	49	5		5	SBDS	7	66453484	Silent	SNP	T	TCGA-BA-6870-01A-11D-1870-08		66453484	92685179	45	3971											
COL1A2	1278	broad.mit.edu	37	chr7	94037520	94037520	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgggcttcctggtgagaGaggacgtgttggtgcccctg	4	10	17	10	2	0	2	0	1	0	1	1	4	1	3	4	4	1	2	4	4	0	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:94037520G>T	uc003ung.1	+	14	1136	c.665G>T	c.(664-666)AGA>ATA	p.R222I	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	222					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCTGGTGAGAGAGGACGTGTT	0.408										HNSCC(75;0.22)			6	76					8.12818e-05	9.18838e-05	1	0	T	94037520	T	T	94037520	3	4	17	1	0	0	0	0	1	0	0	0	3693	942	33	2	719	2	COL1A2	7	94037520	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	27584036	94037520	65101143	46	3972											
FBXO24	26261	broad.mit.edu	37	chr7	100198322	100198322	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccccaggaccccggggggAtggcccaggcctgcgaggag	7	2	17	15	2	0	0	0	0	0	0	0	4	0	3	6	7	1	0	6	7	0	0			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:100198322A>G	uc003uvm.1	+	10	1836	c.1543A>G	c.(1543-1545)ATG>GTG	p.M515V	FBXO24_uc003uvn.1_Missense_Mutation_p.M153V|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Missense_Mutation_p.M553V|FBXO24_uc011kka.1_Missense_Mutation_p.M503V|PCOLCE_uc011kkb.1_5'Flank|PCOLCE_uc003uvo.2_5'Flank|PCOLCE_uc010lhb.1_5'Flank	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	515						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCCCGGGGGGATGGCCCAGGC	0.662													3	56					0	0	0	0	G	100198322	G	G	100198322	3	3	17	1	0	0	0	0	1	0	0	0	5767	333	12	5	1738	5	FBXO24	7	100198322	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	6160802	100198322	58940341	47	3973											
GNB2	2783	broad.mit.edu	37	chr7	100276221	100276224	+	Frame_Shift_Del	DEL	GAAG	-	-																															tgcaacatctgggatgccatGaagggcgaccgtgcaggtga																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:100276221_100276224delGAAG	uc003uwb.2	+	9	1173_1176	c.900_903delGAAG	c.(898-903)ATGAAGfs	p.M300fs	GNB2_uc003uwc.2_Frame_Shift_Del_p.M256fs|GNB2_uc010lhd.2_Frame_Shift_Del_p.M256fs|GNB2_uc010lhe.2_Frame_Shift_Del_p.M256fs|GNB2_uc003uwd.2_Frame_Shift_Del_p.M200fs|GNB2_uc010lhf.2_Frame_Shift_Del_p.M200fs|GNB2_uc003uwe.2_Frame_Shift_Del_p.M300fs|GNB2_uc003uwf.2_Frame_Shift_Del_p.M200fs	NM_005273	NP_005264	P62879	GBB2_HUMAN	guanine nucleotide-binding protein, beta-2	300_301					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	perinuclear region of cytoplasm|plasma membrane	GTPase activity|GTPase binding|signal transducer activity			ovary(2)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)	Ovarian(593;0.238)				GGGATGCCATGAAGGGCGACCGTG	0.608													---	---	---								-	100276224	-	-	100276221	7	5	17	1	0	1	0	1	0	0	0	0	6554	1290	45	0	930	0	GNB2	7	100276221	Frame_Shift_Del	DEL	GAAG	TCGA-BA-6870-01A-11D-1870-08	77899	100276221	58862442	48	3974											
CTTNBP2	83992	broad.mit.edu	37	chr7	117450836	117450836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccttcttttgtctgctctCagcagcagccagctgtgcgg	5	13	10	13	1	3	0	1	0	3	0	4	0	3	0	2	1	7	4	2	1	1	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:117450836C>T	uc003vjf.2	-	3	489	c.397G>A	c.(397-399)GAG>AAG	p.E133K		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	133	Potential.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGTCTGCTCTCAGCAGCAGCC	0.483													39	266					0	0	0	0	T	117450836	T	T	117450836	3	4	17	1	0	0	0	0	1	0	0	0	4062	835	29	2	4678	2	CTTNBP2	7	117450836	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	17174615	117450836	41687827	49	3975											
AKR1B10	57016	broad.mit.edu	37	chr7	134221441	134221441	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaggggctggtgaaagccCttggggtctccaatttcagc	8	10	14	9	0	2	2	1	2	1	0	3	2	2	2	2	5	2	1	2	5	2	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:134221441C>A	uc003vrr.2	+	5	789	c.469C>A	c.(469-471)CTT>ATT	p.L157I		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	157					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						GGTGAAAGCCCTTGGGGTCTC	0.488													36	148					5.71845e-15	7.01319e-15	1	0	A	134221441	A	A	134221441	3	1	17	1	0	0	0	0	1	0	0	0	467	681	24	4	487	4	AKR1B10	7	134221441	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	16770605	134221441	24917222	50	3976											
CNTNAP2	26047	broad.mit.edu	37	chr7	146829576	146829576	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaacatcacacagaccaaGatgagccaaatcgatatttc	17	8	5	11	1	2	3	2	1	0	2	4	4	2	3	2	0	2	0	2	0	4	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:146829576G>T	uc003weu.1	+	8	1839	c.1323G>T	c.(1321-1323)AAG>AAT	p.K441N		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	441	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CACAGACCAAGATGAGCCAAA	0.413										HNSCC(39;0.1)			22	48					1.22574e-08	1.42273e-08	1	0	T	146829576	T	T	146829576	3	4	17	1	0	0	0	0	1	0	0	0	3662	933	33	2	1353	2	CNTNAP2	7	146829576	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	12608135	146829576	12309087	51	3977											
PAXIP1	22976	broad.mit.edu	37	chr7	154738224	154738225	+	Frame_Shift_Ins	INS	-	T	T																															taagcggggaaacgtacctaINStgcctctggcaaaatattct																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr7:154738224_154738225insT	uc003wlp.2	-	19	3173_3174	c.3130_3131insA	c.(3130-3132)ATAfs	p.I1044fs	LOC100132707_uc011kvr.1_Intron|LOC100132707_uc003wlo.2_Intron|PAXIP1_uc003wlq.1_Frame_Shift_Ins_p.I1010fs|PAXIP1_uc011kvs.1_Frame_Shift_Ins_p.I1008fs	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	1044	Interaction with TP53BP1.|BRCT 6.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		AAACGTACCTATGCCTCTGGCA	0.406													---	---	---								T	154738225	T	T	154738224	7	5	17	1	0	1	1	0	0	0	0	0	11541	449	16	0	90	0	PAXIP1	7	154738224	Frame_Shift_Ins	INS	-	TCGA-BA-6870-01A-11D-1870-08	7908648	154738224	4400439	52	3978											
RUNX1T1	862	broad.mit.edu	37	chr8	93017495	93017496	+	Missense_Mutation	DNP	GG	CA	CA																															ggccagtcttgcgcagtggaGgagctcacgctgcagcaggg																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr8:93017495_93017496GG>CA	uc003yfd.2	-	5	672_673	c.588_589CC>TG	c.(586-591)CTCCTC>CTTGTC	p.L197V	RUNX1T1_uc003yfc.1_Missense_Mutation_p.L170V|RUNX1T1_uc003yfe.1_Missense_Mutation_p.L160V|RUNX1T1_uc010mao.2_Missense_Mutation_p.L170V|RUNX1T1_uc011lgi.1_Missense_Mutation_p.L208V|RUNX1T1_uc003yfb.1_Missense_Mutation_p.L160V|RUNX1T1_uc003yff.1_Missense_Mutation_p.L160V	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	197	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.L159L(1)		lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GCGCAGTGGAGGAGCTCACGCT	0.554													6	71					0	0	0	0	CA	93017496	CA	CA	93017495	3	2	17	1	0	0	0	0	1	0	0	0	13812	1000	35	4	1253	4	RUNX1T1	8	93017495	Missense_Mutation	DNP	GG	TCGA-BA-6870-01A-11D-1870-08		93017495	53346527	53	3979											
TTC35	9694	broad.mit.edu	37	chr8	109462150	109462150	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taattaatgaatatgcttctAagctgggagatgatagtaag	15	13	10	3	0	1	3	0	2	1	1	1	4	1	3	0	1	2	3	0	1	7	7			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr8:109462150A>G	uc003ymw.1	+	2	174	c.139A>G	c.(139-141)AAG>GAG	p.K47E		NM_014673	NP_055488	Q15006	TTC35_HUMAN	tetratricopeptide repeat domain 35	47						endoplasmic reticulum|nucleus	binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.34e-10)			ATATGCTTCTAAGCTGGGAGA	0.318													26	171					0	0	0	0	G	109462150	G	G	109462150	3	3	17	1	0	0	0	0	1	0	0	0	16771	363	13	5	145	5	TTC35	8	109462150	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	16444655	109462150	36901872	54	3980											
MTBP	27085	broad.mit.edu	37	chr8	121468867	121468867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcagaaatgttattgactCaaaggaattatggaggggga	14	11	12	4	0	2	2	2	1	1	1	3	5	2	5	0	4	0	1	0	4	5	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr8:121468867C>T	uc003ypc.1	+	7	749	c.704C>T	c.(703-705)TCA>TTA	p.S235L	MTBP_uc011lie.1_RNA	NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	235					cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			GTTATTGACTCAAAGGAATTA	0.313													24	282					0	0	0	0	T	121468867	T	T	121468867	3	4	17	1	0	0	0	0	1	0	0	0	9965	838	29	2	730	2	MTBP	8	121468867	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	12006717	121468867	24895155	55	3981											
DMRT2	10655	broad.mit.edu	37	chr9	1057243	1057243	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagtctattcttaagaggccTtcatctgccatcactcgtgt	8	14	8	11	1	5	1	2	0	3	1	6	2	5	1	2	1	1	0	2	1	2	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr9:1057243T>C	uc003zha.2	+	4	1856	c.1656T>C	c.(1654-1656)CCT>CCC	p.P552P	DMRT2_uc003zgx.3_Silent_p.P319P|DMRT2_uc010mgz.2_Silent_p.P319P|DMRT2_uc003zgy.3_Silent_p.P396P|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Silent_p.P552P	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	552					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		TTAAGAGGCCTTCATCTGCCA	0.393													20	54					0	0	0	0	C	1057243	C	C	1057243	2	2	17	1	0	0	0	0	0	0	0	1	4608	1596	56	5		5	DMRT2	9	1057243	Silent	SNP	T	TCGA-BA-6870-01A-11D-1870-08		1057243	140156188	56	3982											
RC3H2	54542	broad.mit.edu	37	chr9	125618124	125618124	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataatgggaaagatgatcttCttcaaattttgtaccactca	14	14	6	7	0	4	2	2	1	2	1	4	3	4	3	1	1	1	1	1	1	4	6			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr9:125618124C>T	uc010mwc.1	-	14	2729	c.2488G>A	c.(2488-2490)GAA>AAA	p.E830K	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.E830K|RC3H2_uc004bne.3_Missense_Mutation_p.E830K	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	830						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						AGATGATCTTCTTCAAATTTT	0.343													9	59					0	0	0	0	T	125618124	T	T	125618124	3	4	17	1	0	0	0	0	1	0	0	0	13232	922	32	2	1197	2	RC3H2	9	125618124	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	124560881	125618124	15595307	57	3983											
RC3H2	54542	broad.mit.edu	37	chr9	125621230	125621230	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctggtaaggagaagaattCattcgatctcgaggggaaaa	14	8	14	5	2	2	2	1	0	1	2	4	6	2	3	0	5	0	2	0	5	5	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr9:125621230C>T	uc010mwc.1	-	12	2242	c.2001G>A	c.(1999-2001)ATG>ATA	p.M667I	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.M667I|RC3H2_uc004bne.3_Missense_Mutation_p.M667I	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	667	Pro-rich.					cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						GAGAAGAATTCATTCGATCTC	0.522													5	213					0	0	0	0	T	125621230	T	T	125621230	3	4	17	1	0	0	0	0	1	0	0	0	13232	826	29	2	1692	2	RC3H2	9	125621230	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	3106	125621230	15592201	58	3984											
TTF1	7270	broad.mit.edu	37	chr9	135276927	135276927	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcacaccttcttccatcaTggcgccatcaccttctactg	7	14	4	16	1	5	0	3	0	2	0	6	0	6	0	4	1	1	0	4	1	1	5			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr9:135276927T>C	uc004cbl.2	-	2	1334	c.1282A>G	c.(1282-1284)ATG>GTG	p.M428V	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	428					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		TCTTCCATCATGGCGCCATCA	0.507													66	78					0	0	0	0	C	135276927	C	C	135276927	3	2	17	1	0	0	0	0	1	0	0	0	16786	1464	51	5	1475	5	TTF1	9	135276927	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08	9655697	135276927	5936504	59	3985											
OR56A1	120796	broad.mit.edu	37	chr11	6048343	6048344	+	Frame_Shift_Ins	INS	-	A	A																															attctgttaagggtgaaattINSatcacaggagagcctggaca																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:6048343_6048344insA	uc010qzw.1	-	1	591_592	c.591_592insT	c.(589-594)GATAATfs	p.D197fs		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	197_198	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGGTGAAATTATCACAGGAGA	0.46													---	---	---								A	6048344	A	A	6048343	7	5	17	1	0	1	1	0	0	0	0	0	11187	1754	61	0	368	0	OR56A1	11	6048343	Frame_Shift_Ins	INS	-	TCGA-BA-6870-01A-11D-1870-08		6048343	128958173	60	3986											
OR5I1	10798	broad.mit.edu	37	chr11	55703033	55703033	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcagcactggaatgaaaaTggtgtagaacactgagataa	17	9	10	5	0	1	3	1	2	0	2	1	5	1	4	0	2	2	2	0	2	6	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:55703033T>C	uc010ris.1	-	1	844	c.844A>G	c.(844-846)ATT>GTT	p.I282V		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGAATGAAAATGGTGTAGAAC	0.383													12	26					0	0	0	0	C	55703033	C	C	55703033	3	2	17	1	0	0	0	0	1	0	0	0	11218	1464	51	5	103	5	OR5I1	11	55703033	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08	49654690	55703033	79303483	61	3987											
MS4A12	54860	broad.mit.edu	37	chr11	60264874	60264874	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accaagcagctttatggctcCtggatttcaacagcctctgg	9	11	9	12	0	2	0	1	0	1	0	3	1	3	1	3	3	4	3	3	3	3	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:60264874C>A	uc001npr.2	+	2	140	c.83C>A	c.(82-84)CCT>CAT	p.P28H	MS4A12_uc009ynb.2_Missense_Mutation_p.P28H	NM_017716	NP_060186	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member	28	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						TTTATGGCTCCTGGATTTCAA	0.478													27	83					2.48779e-11	2.96709e-11	1	0	A	60264874	A	A	60264874	3	1	17	1	0	0	0	0	1	0	0	0	9909	681	24	4	85	4	MS4A12	11	60264874	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	4561841	60264874	74741642	62	3988											
PC	5091	broad.mit.edu	37	chr11	66617874	66617874	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccgtgcagtcgaaggccgcGtacagtccccgagccccctc	6	5	12	18	5	0	0	0	0	0	0	3	2	1	0	6	1	3	2	6	1	2	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:66617874G>A	uc001ojn.1	-	17	2584	c.2535C>T	c.(2533-2535)TAC>TAT	p.Y845Y	PC_uc001ojo.1_Silent_p.Y845Y|PC_uc001ojp.1_Silent_p.Y845Y|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	845					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CGAAGGCCGCGTACAGTCCCC	0.597													9	87					0	0	0	0	A	66617874	A	A	66617874	2	1	17	1	0	0	0	0	0	0	0	1	11551	1140	40	1		1	PC	11	66617874	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08	6353000	66617874	68388642	63	3989											
MMP8	4317	broad.mit.edu	37	chr11	102585393	102585393	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atagtttgatatatccttggGataaccttgcagaatatcat	13	15	7	6	0	1	2	1	1	0	1	2	3	2	3	2	1	2	2	2	1	6	8			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr11:102585393G>A	uc001phe.2	-	8	1183	c.1084C>T	c.(1084-1086)CCC>TCC	p.P362S	MMP8_uc010rut.1_Intron|MMP8_uc010ruu.1_Missense_Mutation_p.P339S	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	362	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		ATATCCTTGGGATAACCTTGC	0.383													10	174					0	0	0	0	A	102585393	A	A	102585393	3	1	17	1	0	0	0	0	1	0	0	0	9721	1174	41	2	331	2	MMP8	11	102585393	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	35967519	102585393	32421123	64	3990											
PARP11	57097	broad.mit.edu	37	chr12	3935380	3935380	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcgctgctttccagtggtGagattcatttgcttcatttc	7	16	9	9	1	2	1	2	1	0	1	4	2	3	1	1	1	3	3	1	1	1	5			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:3935380G>A	uc001qmk.1	-	3	322	c.267C>T	c.(265-267)CTC>CTT	p.L89L	PARP11_uc001qml.2_Silent_p.L96L|PARP11_uc009zef.2_RNA|PARP11_uc001qmm.2_Silent_p.L15L|PARP11_uc001qmn.2_Silent_p.L15L	NM_020367	NP_065100	Q9NR21	PAR11_HUMAN	poly (ADP-ribose) polymerase family, member 11	89	WWE.						NAD+ ADP-ribosyltransferase activity			ovary(1)|central_nervous_system(1)	2			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)			TTCCAGTGGTGAGATTCATTT	0.358													23	172					0	0	0	0	A	3935380	A	A	3935380	2	1	17	1	0	0	0	0	0	0	0	1	11510	1277	45	2		2	PARP11	12	3935380	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08		3935380	129916515	65	3991											
DPPA3	359787	broad.mit.edu	37	chr12	7864205	7864205	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aatccaacctacatcccaggGtctccacaaatgctcaccga	13	7	5	16	1	2	0	1	0	1	0	5	1	4	0	5	1	3	1	5	1	4	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:7864205G>T	uc001qtf.2	+	1	117	c.39G>T	c.(37-39)GGG>GGT	p.G13G		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	13						cytoplasm|nucleus					0				Kidney(36;0.0887)		ACATCCCAGGGTCTCCACAAA	0.483													3	43					0.004672	0.0050195	1	0	T	7864205	T	T	7864205	2	4	17	1	0	0	0	0	0	0	0	1	4757	1248	44	4		4	DPPA3	12	7864205	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08	3928825	7864205	125987690	66	3992											
PDZRN4	29951	broad.mit.edu	37	chr12	41966610	41966610	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaagaactgagaaacattGagcttgagtgtcagaatatc	16	10	10	5	0	1	6	1	4	0	3	2	7	1	6	0	0	3	1	0	0	5	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:41966610G>A	uc010skn.1	+	10	1500	c.1432G>A	c.(1432-1434)GAG>AAG	p.E478K	PDZRN4_uc001rmq.3_Missense_Mutation_p.E419K|PDZRN4_uc009zjz.2_Missense_Mutation_p.E417K|PDZRN4_uc001rmr.2_Missense_Mutation_p.E304K	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	677	Potential.						ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAGAAACATTGAGCTTGAGTG	0.453													13	80					0	0	0	0	A	41966610	A	A	41966610	3	1	17	1	0	0	0	0	1	0	0	0	11764	1291	45	2	2140	2	PDZRN4	12	41966610	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	34102405	41966610	91885285	67	3993											
MLL2	8085	broad.mit.edu	37	chr12	49434544	49434544	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgggctctggggctctacctGagatgcccgaggggtcaggg	5	7	18	11	2	3	1	1	1	2	1	3	3	3	1	2	6	2	2	2	6	1	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:49434544G>A	uc001rta.3	-	31	7009	c.7009C>T	c.(7009-7011)CAG>TAG	p.Q2337*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2337	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCTCTACCTGAGATGCCCGA	0.627			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			17	38					0	0	0	0	A	49434544	A	A	49434544	4	1	17	1	0	0	0	0	0	1	0	0	9674	1299	45	2	9700	2	MLL2	12	49434544	Nonsense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	7467934	49434544	84417351	68	3994											
NCKAP1L	3071	broad.mit.edu	37	chr12	54936370	54936370	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctttcaggtggtggaggaGtcatccttcctgaccctgga	6	12	12	11	0	3	1	2	1	1	0	5	4	5	4	3	5	0	0	3	5	0	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:54936370G>A	uc001sgc.3	+	31	3364	c.3285G>A	c.(3283-3285)GAG>GAA	p.E1095E	NCKAP1L_uc010sox.1_Silent_p.E637E|NCKAP1L_uc010soy.1_Silent_p.E1045E	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	1095					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TGGTGGAGGAGTCATCCTTCC	0.527													18	136					0	0	0	0	A	54936370	A	A	54936370	2	1	17	1	0	0	0	0	0	0	0	1	10276	1020	36	4		4	NCKAP1L	12	54936370	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08	5501826	54936370	78915525	69	3995											
LRIG3	121227	broad.mit.edu	37	chr12	59266402	59266402	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttggagtcctgtagttttcTaaagtctgtttaaaggtaca	10	17	9	5	0	2	0	0	0	2	0	3	1	3	1	1	2	1	4	1	2	6	8			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:59266402T>G	uc001sqr.2	-	19	3558	c.3312A>C	c.(3310-3312)TTA>TTC	p.L1104F	LRIG3_uc009zqh.2_Missense_Mutation_p.L1044F|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	1104						integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			TGTAGTTTTCTAAAGTCTGTT	0.383													16	98					0	0	0	0	G	59266402	G	G	59266402	3	3	17	1	0	0	0	0	1	0	0	0	8996	1519	53	5	51	5	LRIG3	12	59266402	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08	4330032	59266402	74585493	70	3996											
DPY19L2	283417	broad.mit.edu	37	chr12	64041067	64041067	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaggttctattctggtgaCattccagcaggtcttagttt	9	15	10	7	0	3	2	0	1	3	1	4	2	4	2	1	3	1	3	1	3	3	6			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:64041067C>T	uc001srp.1	-	5	848	c.667G>A	c.(667-669)GTC>ATC	p.V223I	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	223					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		ATTCTGGTGACATTCCAGCAG	0.318													17	133					0	0	0	0	T	64041067	T	T	64041067	3	4	17	1	0	0	0	0	1	0	0	0	4763	478	17	4	1681	4	DPY19L2	12	64041067	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	4774665	64041067	69810828	71	3997											
PIWIL1	9271	broad.mit.edu	37	chr12	130847537	130847537	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttctctggcctgtttcagcGgctctgagggcttggaatag	5	13	13	10	1	3	1	1	1	2	0	4	2	3	2	1	4	1	3	1	4	2	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr12:130847537G>A	uc001uik.2	+	18	2133	c.2043G>A	c.(2041-2043)GCG>GCA	p.A681A	PIWIL1_uc001uij.1_Silent_p.A681A	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	681	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CTGTTTCAGCGGCTCTGAGGG	0.512													26	62					0	0	0	0	A	130847537	A	A	130847537	2	1	17	1	0	0	0	0	0	0	0	1	12012	1130	39	1		1	PIWIL1	12	130847537	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08	66806470	130847537	3004358	72	3998											
WASF3	10810	broad.mit.edu	37	chr13	27255411	27255411	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccgcctccccctcaggccCcagaggggtcccaggcctct	4	5	10	22	1	2	1	1	0	1	1	4	1	4	1	9	4	0	0	9	4	0	0			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr13:27255411C>T	uc001uqv.2	+	8	1162	c.937C>T	c.(937-939)CCA>TCA	p.P313S	WASF3_uc001uqw.2_Missense_Mutation_p.P310S	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	313					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CCCTCAGGCCCCAGAGGGGTC	0.652													32	97					0	0	0	0	T	27255411	T	T	27255411	3	4	17	1	0	0	0	0	1	0	0	0	17322	623	22	4	959	4	WASF3	13	27255411	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08		27255411	87914467	73	3999											
BRCA2	675	broad.mit.edu	37	chr13	32936727	32936727	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttgggtttataatcactatAgatggatcatatggaaactg	13	15	9	4	0	2	1	2	0	0	1	2	3	2	3	0	3	1	1	0	3	6	7			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr13:32936727A>T	uc001uub.1	+	17	8100	c.7873A>T	c.(7873-7875)AGA>TGA	p.R2625*		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2625					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TAATCACTATAGATGGATCAT	0.368			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			26	72					0	0	0	0	T	32936727	T	T	32936727	4	4	17	1	0	0	0	0	0	1	0	0	1504	412	15	5	7935	5	BRCA2	13	32936727	Nonsense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	5681316	32936727	82233151	74	4000											
SPTB	6710	broad.mit.edu	37	chr14	65239589	65239589	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgcgtcgatgagtcgctcGatgaaggcattcacattgtc	8	10	11	12	5	1	2	1	2	0	0	5	4	1	2	1	1	0	2	1	1	1	2	rs142168941		TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr14:65239589G>A	uc001xht.2	-	25	5316	c.5262C>T	c.(5260-5262)ATC>ATT	p.I1754I	SPTB_uc001xhr.2_Silent_p.I1754I|SPTB_uc001xhs.2_Silent_p.I1754I|SPTB_uc001xhu.2_Silent_p.I1754I|SPTB_uc010aqi.2_Silent_p.I415I	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1754	Spectrin 14.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGAGTCGCTCGATGAAGGCAT	0.637													12	21					0	0	0	0	A	65239589	A	A	65239589	2	1	17	1	0	0	0	0	0	0	0	1	15184	1048	37	1		1	SPTB	14	65239589	Silent	SNP	G	TCGA-BA-6870-01A-11D-1870-08		65239589	42109951	75	4001											
ABCD4	5826	broad.mit.edu	37	chr14	74766262	74766262	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatcttaccgtggagttcaGaacaatgagcatgacagcca	14	8	10	9	1	2	4	1	2	1	2	2	5	2	5	2	1	4	2	2	1	3	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr14:74766262G>C	uc001xpr.2	-	3	426	c.274C>G	c.(274-276)CTG>GTG	p.L92V	ABCD4_uc001xps.2_Intron|ABCD4_uc001xpt.2_Intron|ABCD4_uc010tur.1_Missense_Mutation_p.L5V|ABCD4_uc001xpu.2_5'UTR|ABCD4_uc001xpv.2_Intron	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	92	ABC transmembrane type-1.|Helical; (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		GTGGAGTTCAGAACAATGAGC	0.512													20	72					0	0	0	0	C	74766262	C	C	74766262	3	2	17	1	0	0	0	0	1	0	0	0	63	933	33	2	1614	2	ABCD4	14	74766262	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	9526673	74766262	32583278	76	4002											
NRXN3	9369	broad.mit.edu	37	chr14	79181301	79181301	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcattgatgggcgcagcaaGaacattcgacagctggcaga	12	8	12	9	2	1	3	1	1	0	2	2	4	1	3	0	2	3	4	0	2	2	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr14:79181301G>C	uc001xun.2	+	5	1235	c.744G>C	c.(742-744)AAG>AAC	p.K248N	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.K382N	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	621	Extracellular (Potential).|Laminin G-like 3.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GGCGCAGCAAGAACATTCGAC	0.557													11	36					0	0	0	0	C	79181301	C	C	79181301	3	2	17	1	0	0	0	0	1	0	0	0	10721	933	33	2	754	2	NRXN3	14	79181301	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	4415039	79181301	28168239	77	4003											
LTK	4058	broad.mit.edu	37	chr15	41797201	41797201	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtgccatcccaaagtcccCaatcttggccactcggctgg	7	9	9	16	2	1	0	0	0	1	0	5	0	3	0	5	3	1	1	5	3	2	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr15:41797201C>T	uc001zoa.3	-	16	2165	c.1987G>A	c.(1987-1989)GGG>AGG	p.G663R	LTK_uc001zob.3_Missense_Mutation_p.G602R|LTK_uc010ucx.1_Missense_Mutation_p.G533R|LTK_uc010bcg.2_Missense_Mutation_p.G361R	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	663	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CCAAAGTCCCCAATCTTGGCC	0.567										TSP Lung(18;0.14)			11	32					0	0	0	0	T	41797201	T	T	41797201	3	4	17	1	0	0	0	0	1	0	0	0	9130	594	21	4	627	4	LTK	15	41797201	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08		41797201	60734191	78	4004											
THSD4	79875	broad.mit.edu	37	chr15	72023537	72023538	+	Missense_Mutation	DNP	GC	AT	AT																															aacgccatcagcccccaggtGccaccccacaggagaccagg																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr15:72023537_72023538GC>AT	uc002atb.1	+	9	1690_1691	c.1611_1612GC>AT	c.(1609-1614)GTGCCA>GTATCA	p.P538S	THSD4_uc002atd.1_3'UTR|THSD4_uc010ukg.1_Missense_Mutation_p.P178S|THSD4_uc002ate.2_Missense_Mutation_p.P178S	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	538						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						GCCCCCAGGTGCCACCCCACAG	0.54											OREG0023247	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	47					0	0	0	0	AT	72023538	AT	AT	72023537	3	1	17	1	0	0	0	0	1	0	0	0	15944	1306	46	4	1645	4	THSD4	15	72023537	Missense_Mutation	DNP	GC	TCGA-BA-6870-01A-11D-1870-08	30226336	72023537	30507855	79	4005											
DNAH3	55567	broad.mit.edu	37	chr16	20998737	20998737	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagaagacccgataaacctCatggatccaaagccggatac	16	6	8	11	2	1	2	1	0	0	2	2	5	2	4	4	2	3	0	4	2	6	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:20998737C>T	uc010vbe.1	-	47	6916	c.6916G>A	c.(6916-6918)GAG>AAG	p.E2306K	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2306					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CGATAAACCTCATGGATCCAA	0.418													15	82					0	0	0	0	T	20998737	T	T	20998737	3	4	17	1	0	0	0	0	1	0	0	0	4625	835	29	2	5497	2	DNAH3	16	20998737	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08		20998737	69356016	80	4006											
UBFD1	56061	broad.mit.edu	37	chr16	23570829	23570829	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaagtcatgtataagggactCgtccccgaggataaaacatt	15	9	9	8	2	1	0	1	0	0	0	3	3	2	2	2	2	1	1	2	2	5	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:23570829C>T	uc002dlv.2	+	3	598	c.396C>T	c.(394-396)CTC>CTT	p.L132L	EARS2_uc002dls.3_5'Flank|EARS2_uc002dlt.3_5'Flank|EARS2_uc002dlu.2_5'Flank	NM_019116	NP_061989	O14562	UBFD1_HUMAN	ubiquitin-binding protein homolog	132	Ubiquitin-like.										0				GBM - Glioblastoma multiforme(48;0.0331)		ATAAGGGACTCGTCCCCGAGG	0.418													8	40					0	0	0	0	T	23570829	T	T	23570829	2	4	17	1	0	0	0	0	0	0	0	1	16952	871	31	1		1	UBFD1	16	23570829	Silent	SNP	C	TCGA-BA-6870-01A-11D-1870-08	2572092	23570829	66783924	81	4007											
GTF3C1	2975	broad.mit.edu	37	chr16	27483198	27483198	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctggcactccatgaaggccTtcacaagaacgtggtccttg	9	10	10	12	1	2	2	1	1	1	1	4	2	4	2	3	3	1	1	3	3	3	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:27483198T>C	uc002dov.1	-	30	4437	c.4397A>G	c.(4396-4398)AAG>AGG	p.K1466R	GTF3C1_uc002dou.2_Missense_Mutation_p.K1466R	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1466						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CATGAAGGCCTTCACAAGAAC	0.627													18	62					0	0	0	0	C	27483198	C	C	27483198	3	2	17	1	0	0	0	0	1	0	0	0	6911	1609	56	5	1964	5	GTF3C1	16	27483198	Missense_Mutation	SNP	T	TCGA-BA-6870-01A-11D-1870-08	3912369	27483198	62871555	82	4008											
HPR	3250	broad.mit.edu	37	chr16	72110554	72110554	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgagagagtgatgcccatCtgcctaccttcaaagaatta	14	10	8	9	0	2	4	1	2	1	2	2	5	2	4	3	0	3	0	3	0	5	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:72110554C>T	uc002fby.2	+	5	651	c.621C>T	c.(619-621)ATC>ATT	p.I207I	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	207	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				TGATGCCCATCTGCCTACCTT	0.448													19	141					0	0	0	0	T	72110554	T	T	72110554	2	4	17	1	0	0	0	0	0	0	0	1	7376	903	32	2		2	HPR	16	72110554	Silent	SNP	C	TCGA-BA-6870-01A-11D-1870-08	44627356	72110554	18244199	83	4009											
LRRC50	123872	broad.mit.edu	37	chr16	84203819	84203819	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaggagaggatggagatcAagagccagaggggaccctcc	14	4	15	8	0	1	4	1	0	0	4	2	8	2	6	3	5	1	0	3	5	3	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr16:84203819A>G	uc002fhl.3	+	8	1566	c.1385A>G	c.(1384-1386)CAA>CGA	p.Q462R	LRRC50_uc010vnw.1_Missense_Mutation_p.Q226R	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	462	Pro-rich.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						GATGGAGATCAAGAGCCAGAG	0.612									Kartagener_syndrome				11	120					0	0	0	0	G	84203819	G	G	84203819	3	3	17	1	0	0	0	0	1	0	0	0	9059	130	5	5	1415	5	LRRC50	16	84203819	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08	12093265	84203819	6150934	84	4010											
TP53	7157	broad.mit.edu	37	chr17	7577556	7577556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccggttcatgccgcccatgCaggaactgttacacatgtag	9	10	10	12	2	1	0	1	0	0	0	2	1	2	1	3	2	4	4	3	2	3	3	rs121912655		TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr17:7577556C>T	uc002gim.2	-	7	919	c.725G>A	c.(724-726)TGC>TAC	p.C242Y	TP53_uc002gig.1_Missense_Mutation_p.C242Y|TP53_uc002gih.2_Missense_Mutation_p.C242Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C110Y|TP53_uc010cng.1_Missense_Mutation_p.C110Y|TP53_uc002gii.1_Missense_Mutation_p.C110Y|TP53_uc010cnh.1_Missense_Mutation_p.C242Y|TP53_uc010cni.1_Missense_Mutation_p.C242Y|TP53_uc002gij.2_Missense_Mutation_p.C242Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C149Y|TP53_uc002gio.2_Missense_Mutation_p.C110Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	242	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).	Zinc.	C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(63)|p.C242Y(37)|p.C242S(25)|p.C242fs*5(16)|p.C242R(11)|p.C242W(7)|p.0?(7)|p.N239_C242delNSSC(3)|p.C242*(3)|p.C242C(2)|p.C242G(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241_G245delSCMGG(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGCCCATGCAGGAACTGTT	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	62					0	0	0	0	T	7577556	T	T	7577556	3	4	17	1	0	0	0	0	1	0	0	0	16448	710	25	4	565	4	TP53	17	7577556	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08		7577556	73617654	85	4011											
SCO1	6341	broad.mit.edu	37	chr17	10584496	10584496	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaagcagctatttctcccttCctcttgttctggccaaaata	9	14	6	12	0	3	0	0	0	3	0	5	1	4	0	3	1	2	3	3	1	5	6			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr17:10584496C>T	uc002gmr.3	-	6	907	c.846G>A	c.(844-846)AGG>AGA	p.R282R	SCO1_uc002gms.3_Silent_p.R251R	NM_004589	NP_004580	O75880	SCO1_HUMAN	cytochrome oxidase deficient homolog 1	282					cellular copper ion homeostasis|copper ion transport|generation of precursor metabolites and energy|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0						TTTCTCCCTTCCTCTTGTTCT	0.438													46	74					0	0	0	0	T	10584496	T	T	10584496	2	4	17	1	0	0	0	0	0	0	0	1	13996	854	30	2		2	SCO1	17	10584496	Silent	SNP	C	TCGA-BA-6870-01A-11D-1870-08	3006940	10584496	70610714	86	4012											
MAP2K4	6416	broad.mit.edu	37	chr17	12016562	12016575	+	Frame_Shift_Del	DEL	CCAATATTCTTCTG	-	-																															tcttgcagatatcaaaccttCcaatattcttctggacagaa																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr17:12016562_12016575delCCAATATTCTTCTG	uc002gnj.2	+	7	767_780	c.698_711delCCAATATTCTTCTG	c.(697-711)TCCAATATTCTTCTGfs	p.S233fs	MAP2K4_uc002gnk.2_Frame_Shift_Del_p.S244fs|MAP2K4_uc010vvi.1_Frame_Shift_Del_p.S115fs|MAP2K4_uc010vvj.1_Frame_Shift_Del_p.S105fs	NM_003010	NP_003001	P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	233_237	Protein kinase.				cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.N234I(1)|p.?(1)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		ATCAAACCTTCCAATATTCTTCTGGACAGAAGTG	0.388			D|Mis|N		pancreatic|breast|colorectal								---	---	---								-	12016575	-	-	12016562	7	5	17	1	0	1	0	1	0	0	0	0	9292	855	30	0	724	0	MAP2K4	17	12016562	Frame_Shift_Del	DEL	CCAATATTCTTCTG	TCGA-BA-6870-01A-11D-1870-08	1432066	12016562	69178648	87	4013											
MKNK2	2872	broad.mit.edu	37	chr19	2041985	2041985	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtcgtagatgctagcctcctCgctgaaggcctccactacct	7	10	9	15	2	0	2	0	1	0	1	4	2	2	2	5	1	3	3	5	1	4	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:2041985C>G	uc002lus.2	-	11	1044	c.799G>C	c.(799-801)GAG>CAG	p.E267Q	MKNK2_uc002luq.1_Missense_Mutation_p.E11Q|MKNK2_uc010xgu.1_Missense_Mutation_p.E106Q|MKNK2_uc010xgv.1_Missense_Mutation_p.E136Q|MKNK2_uc002lur.2_Missense_Mutation_p.E267Q|MKNK2_uc002lut.1_Missense_Mutation_p.E11Q	NM_199054	NP_951009	Q9HBH9	MKNK2_HUMAN	MAP kinase-interacting serine/threonine kinase 2	267	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(1)|breast(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTAGCCTCCTCGCTGAAGGCC	0.667													3	8					0	0	0	0	G	2041985	G	G	2041985	3	3	17	1	0	0	0	0	1	0	0	0	9658	893	31	3	709	3	MKNK2	19	2041985	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08		2041985	57086998	88	4014											
TLE6	79816	broad.mit.edu	37	chr19	2987759	2987759	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	accaggatcctgtgacccagGaacagacccatgtcctgaag	12	6	10	13	0	0	3	0	2	0	1	2	5	2	5	5	2	1	0	5	2	2	0			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:2987759G>A	uc002lwu.2	+	8	627	c.227G>A	c.(226-228)GGA>GAA	p.G76E	TLE6_uc002lwt.2_Missense_Mutation_p.G199E|TLE6_uc010dtg.2_Missense_Mutation_p.G199E|TLE6_uc002lwv.2_5'UTR	NM_024760	NP_079036	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 isoform 2	76					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGACCCAGGAACAGACCCA	0.607													7	91					0	0	0	0	A	2987759	A	A	2987759	3	1	17	1	0	0	0	0	1	0	0	0	16008	1174	41	2	626	2	TLE6	19	2987759	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	945774	2987759	56141224	89	4015											
CHAF1A	10036	broad.mit.edu	37	chr19	4418037	4418037	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataactaagaaattcgtcaaAggctctacagagaagaacaa	20	7	7	7	1	2	3	1	0	1	3	3	4	2	3	0	1	3	1	0	1	8	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:4418037A>G	uc002mal.2	+	4	1081	c.981A>G	c.(979-981)AAA>AAG	p.K327K		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	327	Arg/Glu/Lys-rich.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AATTCGTCAAAGGCTCTACAG	0.353								Chromatin_Structure					7	97					0	0	0	0	G	4418037	G	G	4418037	2	3	17	1	0	0	0	0	0	0	0	1	3326	69	3	5		5	CHAF1A	19	4418037	Silent	SNP	A	TCGA-BA-6870-01A-11D-1870-08	1430278	4418037	54710946	90	4016											
ZNF433	163059	broad.mit.edu	37	chr19	12126445	12126446	+	Frame_Shift_Ins	INS	-	A	A																															tctccagtgtgagttctttcINSatgatatcggaaggaactgg																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:12126445_12126446insA	uc002msy.1	-	4	1407_1408	c.1236_1237insT	c.(1234-1239)CATGAAfs	p.H412fs	uc002msx.1_Intron|ZNF433_uc002msz.1_Frame_Shift_Ins_p.H377fs	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	412_413	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGAGTTCTTTCATGATATCGGA	0.431													---	---	---								A	12126446	A	A	12126445	7	5	17	1	0	1	1	0	0	0	0	0	17974	835	29	0	788	0	ZNF433	19	12126445	Frame_Shift_Ins	INS	-	TCGA-BA-6870-01A-11D-1870-08	7708408	12126445	47002538	91	4017											
ZNF493	284443	broad.mit.edu	37	chr19	21606460	21606460	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaaagcctttagtattttCtcaacccctactaaacataa	14	12	4	11	0	1	0	1	0	1	0	2	0	1	0	3	1	4	2	3	1	8	8			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:21606460C>T	uc002npx.2	+	2	895	c.615C>T	c.(613-615)TTC>TTT	p.F205F	ZNF493_uc002npw.2_Silent_p.F333F|ZNF493_uc002npy.2_Silent_p.F205F	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	205	C2H2-type 7; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTAGTATTTTCTCAACCCCTA	0.348													4	90					0	0	0	0	T	21606460	T	T	21606460	2	4	17	1	0	0	0	0	0	0	0	1	18011	912	32	2		2	ZNF493	19	21606460	Silent	SNP	C	TCGA-BA-6870-01A-11D-1870-08	9480015	21606460	37522523	92	4018											
CHST8	64377	broad.mit.edu	37	chr19	34263477	34263477	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctttgtccgcgagcccttcGagaggctggtgtccgccttc	3	12	12	14	4	1	1	0	0	1	1	5	3	3	1	4	2	1	1	4	2	0	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:34263477G>A	uc002nus.3	+	5	1289	c.784G>A	c.(784-786)GAG>AAG	p.E262K	CHST8_uc002nut.3_Missense_Mutation_p.E262K|CHST8_uc002nuu.2_Missense_Mutation_p.E262K	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	262	PAPS (By similarity).|Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					CGAGCCCTTCGAGAGGCTGGT	0.617													7	95					0	0	0	0	A	34263477	A	A	34263477	3	1	17	1	0	0	0	0	1	0	0	0	3425	1059	37	1	794	1	CHST8	19	34263477	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	12657017	34263477	24865506	93	4019											
LMTK3	114783	broad.mit.edu	37	chr19	48989041	48989041	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcggggaatcaattctccaCggggcctgaggatggacaga	10	8	14	9	2	2	2	1	1	1	1	4	5	2	5	2	6	0	0	2	6	2	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr19:48989041C>A	uc002pjk.2	-	16	4459	c.4459G>T	c.(4459-4461)GTG>TTG	p.V1487L		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CAATTCTCCACGGGGCCTGAG	0.458													7	15					0.00307968	0.00333632	1	0	A	48989041	A	A	48989041	3	1	17	1	0	0	0	0	1	0	0	0	8902	536	19	3	14	3	LMTK3	19	48989041	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	14725564	48989041	10139942	94	4020											
JAG1	182	broad.mit.edu	37	chr20	10653370	10653370	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccaggcgaaactgaaaggCagcacgatgcggttgcggtc	10	5	16	10	4	0	1	0	1	0	0	1	3	0	1	1	5	4	3	1	5	2	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr20:10653370C>G	uc002wnw.2	-	2	882	c.366G>C	c.(364-366)CTG>CTC	p.L122L		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	122	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						AACTGAAAGGCAGCACGATGC	0.677									Alagille_Syndrome				9	30					0	0	0	0	G	10653370	G	G	10653370	2	3	17	1	0	0	0	0	0	0	0	1	7973	697	25	4		4	JAG1	20	10653370	Silent	SNP	C	TCGA-BA-6870-01A-11D-1870-08		10653370	52372150	95	4021											
XRN2	22803	broad.mit.edu	37	chr20	21314185	21314186	+	Missense_Mutation	DNP	GA	AT	AT																															cattcctgttcttgcagcatGatgaacttgccgatagtctt																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr20:21314185_21314186GA>AT	uc002wsf.1	+	10	957_958	c.862_863GA>AT	c.(862-864)GAT>ATT	p.D288I	XRN2_uc002wsg.1_Missense_Mutation_p.D212I|XRN2_uc010zsk.1_Missense_Mutation_p.D234I	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	288					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						CTTGCAGCATGATGAACTTGCC	0.391													17	129					0	0	0	0	AT	21314186	AT	AT	21314185	3	1	17	1	0	0	0	0	1	0	0	0	17528	1290	45	2	900	2	XRN2	20	21314185	Missense_Mutation	DNP	GA	TCGA-BA-6870-01A-11D-1870-08	10660815	21314185	41711335	96	4022											
SUN5	140732	broad.mit.edu	37	chr20	31587923	31587923	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgtcttctccatgagcttCtggcacagcagcttgcatct	6	13	8	14	0	4	1	0	1	4	0	5	1	4	1	2	1	4	5	2	1	0	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr20:31587923C>G	uc002wyi.2	-	5	390	c.297G>C	c.(295-297)CAG>CAC	p.Q99H		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	99					spermatogenesis					skin(1)	1						CCATGAGCTTCTGGCACAGCA	0.552													8	47					0	0	0	0	G	31587923	G	G	31587923	3	3	17	1	0	0	0	0	1	0	0	0	15460	912	32	2	878	2	SUN5	20	31587923	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	10273738	31587923	31437597	97	4023											
PTPRT	11122	broad.mit.edu	37	chr20	41101056	41101056	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacctcctcggcctcgtactGctgctggttgaacacatact	7	11	9	14	2	0	1	0	1	0	0	3	2	1	1	3	2	5	4	3	2	3	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr20:41101056G>A	uc002xkg.2	-	8	1484	c.1300C>T	c.(1300-1302)CAG>TAG	p.Q434*	PTPRT_uc010ggj.2_Nonsense_Mutation_p.Q434*	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	434	Extracellular (Potential).|Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCCTCGTACTGCTGCTGGTTG	0.627													50	59					0	0	0	0	A	41101056	A	A	41101056	4	1	17	1	0	0	0	0	0	1	0	0	12877	1328	46	4	3182	4	PTPRT	20	41101056	Nonsense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	9513133	41101056	21924464	98	4024											
MYT1	4661	broad.mit.edu	37	chr20	62871243	62871243	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaagtctcgccaatatccGccttccgcacatggtaggca	10	8	8	15	3	1	0	0	0	1	0	4	0	3	0	5	2	0	3	5	2	4	3	rs139674530		TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr20:62871243G>T	uc002yii.2	+	22	3588	c.3224G>T	c.(3223-3225)CGC>CTC	p.R1075L	MYT1_uc002yij.2_Missense_Mutation_p.R734L|MYT1_uc002yik.2_Missense_Mutation_p.R41L	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1075				R -> H (in Ref. 5; AAA59897).	cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GCCAATATCCGCCTTCCGCAC	0.622													37	114					7.04047e-22	8.80059e-22	1	0	T	62871243	T	T	62871243	3	4	17	1	0	0	0	0	1	0	0	0	10159	1087	38	3	3302	3	MYT1	20	62871243	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	21770187	62871243	154277	99	4025											
DOPEY2	9980	broad.mit.edu	37	chr21	37623566	37623566	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcagaaagaaagcccagcGtcacagtaagatgaaggtaa	18	4	12	7	1	1	4	1	1	0	3	1	5	1	4	1	1	3	3	1	1	5	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr21:37623566G>A	uc002yvg.2	+	22	5184	c.5105G>A	c.(5104-5106)CGT>CAT	p.R1702H	DOPEY2_uc011aeb.1_Missense_Mutation_p.R1651H|DOPEY2_uc002yvh.2_Missense_Mutation_p.R553H	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1702					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						AAAGCCCAGCGTCACAGTAAG	0.423													13	77					0	0	0	0	A	37623566	A	A	37623566	3	1	17	1	0	0	0	0	1	0	0	0	4730	1145	40	1	5187	1	DOPEY2	21	37623566	Missense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08		37623566	10506329	100	4026											
PDE9A	5152	broad.mit.edu	37	chr21	44153465	44153465	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttttctttttcattcctaGagcattcaaaatcaatgaac	12	17	3	9	0	5	2	3	1	2	1	6	2	6	2	1	0	2	1	1	0	5	7			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr21:44153465G>A	uc002zbm.2	+	7	561	c.498_splice	c.e7-1	p.R166_splice	PDE9A_uc002zbn.2_Splice_Site_p.R39_splice|PDE9A_uc002zbo.2_Splice_Site_p.R113_splice|PDE9A_uc002zbp.2_Splice_Site|PDE9A_uc002zbq.2_Splice_Site_p.R64_splice|PDE9A_uc002zbs.2_Splice_Site|PDE9A_uc002zbr.2_Splice_Site|PDE9A_uc002zbt.2_Splice_Site_p.R38_splice|PDE9A_uc002zbu.2_Splice_Site_p.R32_splice|PDE9A_uc002zbv.2_Splice_Site_p.R6_splice|PDE9A_uc002zbw.2_Splice_Site|PDE9A_uc002zbx.2_Splice_Site_p.R106_splice|PDE9A_uc002zby.2_Splice_Site|PDE9A_uc002zbz.2_Splice_Site_p.R58_splice|PDE9A_uc002zca.2_Splice_Site_p.R125_splice|PDE9A_uc002zcb.2_Splice_Site_p.R140_splice|PDE9A_uc002zcc.2_Splice_Site_p.R65_splice|PDE9A_uc002zcd.2_Splice_Site_p.R80_splice|PDE9A_uc002zce.2_Splice_Site_p.R99_splice|PDE9A_uc002zcf.2_Splice_Site|PDE9A_uc002zcg.2_Splice_Site|PDE9A_uc002zch.2_Splice_Site	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a						platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						TTCATTCCTAGAGCATTCAAA	0.318													13	36					0	0	0	0	A	44153465	A	A	44153465	5	1	17	1	0	0	0	0	0	0	1	0	11709	956	33	2	603	2	PDE9A	21	44153465	Splice_Site	SNP	G	TCGA-BA-6870-01A-11D-1870-08	6529899	44153465	3976430	101	4027											
NF2	4771	broad.mit.edu	37	chr22	30057252	30057252	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggggcttcacatttatgAccctgagaacagactgaccc	10	9	9	13	0	1	4	1	3	0	2	1	5	1	4	3	2	1	1	3	2	2	3			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chr22:30057252A>G	uc003age.3	+	8	1177	c.734A>G	c.(733-735)GAC>GGC	p.D245G	NF2_uc003afy.3_Missense_Mutation_p.D245G|NF2_uc003afz.3_Missense_Mutation_p.D162G|NF2_uc003agf.3_Missense_Mutation_p.D245G|NF2_uc003agb.3_Missense_Mutation_p.D168G|NF2_uc003agc.3_Missense_Mutation_p.D207G|NF2_uc003agd.3_RNA|NF2_uc003agg.3_Missense_Mutation_p.D245G|NF2_uc003aga.3_Missense_Mutation_p.D203G|NF2_uc003agh.3_Missense_Mutation_p.D204G|NF2_uc003agi.3_Missense_Mutation_p.D162G|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Missense_Mutation_p.D207G	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	245	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.D245fs*31(1)|p.N226_E270del(1)|p.L140_P252del(1)|p.?(1)|p.L127_D382del(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						CACATTTATGACCCTGAGAAC	0.498			D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				3	157					0	0	0	0	G	30057252	G	G	30057252	3	3	17	1	0	0	0	0	1	0	0	0	10411	275	10	5	764	5	NF2	22	30057252	Missense_Mutation	SNP	A	TCGA-BA-6870-01A-11D-1870-08		30057252	21247314	102	4028											
BMX	660	broad.mit.edu	37	chrX	15567988	15567988	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgatgtgggaggtgttcagCctggggaagcagccctatga	8	9	16	8	0	1	2	1	2	0	0	1	4	1	4	2	4	3	2	2	4	2	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:15567988C>A	uc004cww.2	+	18	2009	c.1821C>A	c.(1819-1821)AGC>AGA	p.S607R	BMX_uc004cwx.3_Missense_Mutation_p.S607R|BMX_uc004cwy.3_Missense_Mutation_p.S607R	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	607	Protein kinase.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AGGTGTTCAGCCTGGGGAAGC	0.552													4	197					0.00116845	0.00127645	1	0	A	15567988	A	A	15567988	3	1	17	1	0	0	0	0	1	0	0	0	1476	738	26	4	1887	4	BMX	23	15567988	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08		15567988	139702572	103	4029											
FGD1	2245	broad.mit.edu	37	chrX	54496604	54496604	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaggcacactagccagggCagggggcccagggcagaggc	11	1	17	12	0	0	1	0	0	0	1	0	1	0	1	2	6	2	3	2	6	2	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:54496604C>A	uc004dtg.2	-	4	1680	c.946G>T	c.(946-948)GCC>TCC	p.A316S	FGD1_uc011moi.1_Missense_Mutation_p.A74S	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	316	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CTAGCCAGGGCAGGGGGCCCA	0.557													11	19					4.68919e-08	5.39464e-08	1	0	A	54496604	A	A	54496604	3	1	17	1	0	0	0	0	1	0	0	0	5864	710	25	4	1999	4	FGD1	23	54496604	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	38928616	54496604	100773956	104	4030											
DIAPH2	1730	broad.mit.edu	37	chrX	96213115	96213115	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaaaaatgtataaacctGaagtgtccatgaagagaatc	20	8	8	5	0	0	4	0	2	0	2	2	5	1	4	2	0	1	1	2	0	9	2			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:96213115G>T	uc004efu.3	+	16	2299	c.1903G>T	c.(1903-1905)GAA>TAA	p.E635*	DIAPH2_uc004eft.3_Nonsense_Mutation_p.E635*	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	635	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						GTATAAACCTGAAGTGTCCAT	0.398													20	112					1.96292e-10	2.29892e-10	1	0	T	96213115	T	T	96213115	4	4	17	1	0	0	0	0	0	1	0	0	4541	1291	45	2	1965	2	DIAPH2	23	96213115	Nonsense_Mutation	SNP	G	TCGA-BA-6870-01A-11D-1870-08	41716511	96213115	59057445	105	4031											
IL1RAPL2	26280	broad.mit.edu	37	chrX	104728331	104728332	+	Missense_Mutation	DNP	CC	AA	AA																															tcacagacaagcctcccaagCcattgttccccatggagaat																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:104728331_104728332CC>AA	uc004elz.1	+	6	1480_1481	c.724_725CC>AA	c.(724-726)CCA>AAA	p.P242K		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	242	Ig-like C2-type 3.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						GCCTCCCAAGCCATTGTTCCCC	0.396													21	102					0	0	0	0	AA	104728332	AA	AA	104728331	3	1	17	1	0	0	0	0	1	0	0	0	7701	739	26	4	742	4	IL1RAPL2	23	104728331	Missense_Mutation	DNP	CC	TCGA-BA-6870-01A-11D-1870-08	8515216	104728331	50542229	106	4032											
GLUD2	2747	broad.mit.edu	37	chrX	120182678	120182678	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcgactgtgacatactgatCccagctgccactgagaagca	11	8	10	12	1	0	3	0	3	0	1	2	5	1	3	2	0	4	2	2	0	2	1			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:120182678C>A	uc004eto.2	+	1	1217	c.1140C>A	c.(1138-1140)ATC>ATA	p.I380I		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	380					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	ACATACTGATCCCAGCTGCCA	0.507													64	220					7.05995e-25	8.99798e-25	1	0	A	120182678	A	A	120182678	2	1	17	1	0	0	0	0	0	0	0	1	6514	845	30	2		2	GLUD2	23	120182678	Silent	SNP	C	TCGA-BA-6870-01A-11D-1870-08	15454347	120182678	35087882	107	4033											
STAG2	10735	broad.mit.edu	37	chrX	123200245	123200245	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtactcactatgtaatcCtttggcaacttgctaagata	12	14	7	8	0	1	1	1	0	0	1	2	1	2	1	1	1	3	4	1	1	6	7			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:123200245C>A	uc004etz.3	+	22	2563	c.2224C>A	c.(2224-2226)CTT>ATT	p.L742I	STAG2_uc004eua.2_Missense_Mutation_p.L742I|STAG2_uc004eub.2_Missense_Mutation_p.L742I|STAG2_uc004euc.2_Missense_Mutation_p.L742I|STAG2_uc004eud.2_Missense_Mutation_p.L742I|STAG2_uc004eue.2_Missense_Mutation_p.L742I	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	742					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CTATGTAATCCTTTGGCAACT	0.328													13	110					1.5739e-10	1.86006e-10	1	0	A	123200245	A	A	123200245	3	1	17	1	0	0	0	0	1	0	0	0	15309	681	24	4	2306	4	STAG2	23	123200245	Missense_Mutation	SNP	C	TCGA-BA-6870-01A-11D-1870-08	3017567	123200245	32070315	108	4034											
ATP11C	286410	broad.mit.edu	37	chrX	138820082	138820084	+	In_Frame_Del	DEL	CTT	-	-																															acttagttcttaccctggcaCttcttcttcttacattcttt																										TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:138820082_138820084delCTT	uc004faz.2	-	28	3387_3389	c.3288_3290delAAG	c.(3286-3291)AGAAGT>AGT	p.R1096del	ATP11C_uc004fax.2_In_Frame_Del_p.R304del|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_In_Frame_Del_p.R1096del	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	1096	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TACCCTGGCACTTCTTCTTCTTA	0.355													---	---	---								-	138820084	-	-	138820082	7	5	17	1	0	1	0	1	0	0	0	0	1123	565	20	0	183	0	ATP11C	23	138820082	In_Frame_Del	DEL	CTT	TCGA-BA-6870-01A-11D-1870-08	15619837	138820082	16450478	109	4035											
HCFC1	3054	broad.mit.edu	37	chrX	153223611	153223611	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacttgtgcactgtgatgatAgggcgggtagacgtgttggt	7	12	17	5	2	0	3	0	2	0	1	0	4	0	3	0	3	1	3	0	3	2	4			TCGA-BA-6870-01A-11D-1870-08	TCGA-BA-6870-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdd3f42-cb2f-4faf-8a47-b8bfee058265	7a53ffac-dad3-4e36-b077-c29fc66c6a42	g.chrX:153223611A>T	uc004fjp.2	-	11	2421	c.1893T>A	c.(1891-1893)CCT>CCA	p.P631P		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	631	Interaction with SIN3A.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGTGATGATAGGGCGGGTAG	0.622													18	67					0	0	0	0	T	153223611	T	T	153223611	2	4	17	1	0	0	0	0	0	0	0	1	7030	407	15	5		5	HCFC1	23	153223611	Silent	SNP	A	TCGA-BA-6870-01A-11D-1870-08	14403529	153223611	2046949	110	4036											
AIM1L	55057	broad.mit.edu	37	chr1	26658052	26658052	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgtgagagtggggaactcGccctcagagagaatgtgctg	9	7	16	9	2	1	3	1	1	0	3	2	6	1	4	2	2	2	1	2	2	2	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:26658052G>A	uc001bmd.3	-	14	1537	c.1107C>T	c.(1105-1107)GGC>GGT	p.G369G		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	369	Beta/gamma crystallin 'Greek key' 8.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		TGGGGAACTCGCCCTCAGAGA	0.567													18	29					0	0	0	0	A	26658052	A	A	26658052	2	1	18	1	0	0	0	0	0	0	0	1	431	1074	38	1		1	AIM1L	1	26658052	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08		26658052	222592569	1	4037											
RCC1	1104	broad.mit.edu	37	chr1	28864461	28864461	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaaccgtgtggtcttatCtgtgtccagcgggggccagc	6	9	16	10	2	2	1	0	0	2	1	3	2	3	1	3	4	3	0	3	4	2	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:28864461C>A	uc001bqg.1	+	10	1293	c.1208C>A	c.(1207-1209)TCT>TAT	p.S403Y	SNHG3-RCC1_uc001bqa.1_Missense_Mutation_p.S403Y|SNHG3-RCC1_uc001bqb.1_Missense_Mutation_p.S403Y|SNHG3-RCC1_uc001bqc.1_Missense_Mutation_p.S403Y|RCC1_uc001bqe.1_Missense_Mutation_p.S420Y|RCC1_uc001bqf.1_Missense_Mutation_p.S434Y	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	403	RCC1 7.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGTCTTATCTGTGTCCAGC	0.577													5	20					0.000602214	0.00063964	1	0	A	28864461	A	A	28864461	3	1	18	1	0	0	0	0	1	0	0	0	13238	913	32	2	1339	2	RCC1	1	28864461	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	2206409	28864461	220386160	2	4038											
PTPRU	10076	broad.mit.edu	37	chr1	29609426	29609426	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgagcctaggaaggcctatCtcatctacttccaggcagca	10	10	9	12	0	2	1	1	1	2	0	4	2	3	2	3	3	3	2	3	3	4	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:29609426C>G	uc001bru.2	+	12	2217	c.2107C>G	c.(2107-2109)CTC>GTC	p.L703V	PTPRU_uc001brv.2_Missense_Mutation_p.L703V|PTPRU_uc001brw.2_Missense_Mutation_p.L703V|PTPRU_uc009vtq.2_Missense_Mutation_p.L703V|PTPRU_uc009vtr.2_Missense_Mutation_p.L703V	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	703	Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GAAGGCCTATCTCATCTACTT	0.617													12	53					0	0	0	0	G	29609426	G	G	29609426	3	3	18	1	0	0	0	0	1	0	0	0	12878	913	32	2	2153	2	PTPRU	1	29609426	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	744965	29609426	219641195	3	4039											
C1orf94	84970	broad.mit.edu	37	chr1	34666533	34666533	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaacctacatgtccagcCgagaagaacttgctctatga	15	8	8	10	1	1	4	0	1	1	3	2	5	2	4	3	0	5	1	3	0	6	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:34666533C>T	uc001bxs.3	+	3	999	c.600C>T	c.(598-600)GCC>GCT	p.A200A	C1orf94_uc001bxt.2_Silent_p.A390A	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	200							protein binding				0		Myeloproliferative disorder(586;0.0393)				CATGTCCAGCCGAGAAGAACT	0.592													13	27					0	0	0	0	T	34666533	T	T	34666533	2	4	18	1	0	0	0	0	0	0	0	1	2081	639	23	1		1	C1orf94	1	34666533	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08	5057107	34666533	214584088	4	4040											
INPP5B	3633	broad.mit.edu	37	chr1	38357097	38357097	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cataggcactcccttcccatTtggtctcaaaccatcaaagt	11	11	5	14	0	2	0	2	0	1	0	5	0	4	0	3	2	1	1	3	2	3	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:38357097T>A	uc001ccg.1	-	8	656	c.562A>T	c.(562-564)AAT>TAT	p.N188Y	INPP5B_uc009vvk.1_Missense_Mutation_p.N129Y|INPP5B_uc001ccf.1_Missense_Mutation_p.N24Y|INPP5B_uc010oij.1_5'Flank	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	268					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CCCTTCCCATTTGGTCTCAAA	0.353													44	87					0	0	0	0	A	38357097	A	A	38357097	3	1	18	1	0	0	0	0	1	0	0	0	7794	1841	64	5	2247	5	INPP5B	1	38357097	Missense_Mutation	SNP	T	TCGA-BA-6871-01A-11D-1870-08	3690564	38357097	210893524	5	4041											
FHL3	2275	broad.mit.edu	37	chr1	38463526	38463526	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gctgatcacggtatgtcactCcaccctgtgtcagcgtctgt	6	12	10	13	2	4	1	3	1	1	0	5	1	5	1	2	1	1	2	2	1	1	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:38463526C>G	uc001ccj.2	-	5	605	c.518G>C	c.(517-519)GGA>GCA	p.G173A	FHL3_uc001cck.2_Missense_Mutation_p.G173A|FHL3_uc001ccl.2_Missense_Mutation_p.G173A|FHL3_uc001ccm.2_Missense_Mutation_p.G65A|FHL3_uc009vvl.1_3'UTR	NM_004468	NP_004459	Q13643	FHL3_HUMAN	four and a half LIM domains 3	173	LIM zinc-binding 3.				muscle organ development		zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GTATGTCACTCCACCCTGTGT	0.607													9	31					0	0	0	0	G	38463526	G	G	38463526	3	3	18	1	0	0	0	0	1	0	0	0	5912	855	30	2	332	2	FHL3	1	38463526	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	106429	38463526	210787095	6	4042											
PARS2	25973	broad.mit.edu	37	chr1	55224719	55224719	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacacgagacagcagcaggCgccgccctcttcttggggca	9	5	12	15	3	2	1	0	0	2	1	2	2	2	1	2	3	2	3	2	3	0	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:55224719C>T	uc001cxy.2	-	2	199	c.116G>A	c.(115-117)CGC>CAC	p.R39H		NM_152268	NP_689481	Q7L3T8	SYPM_HUMAN	prolyl-tRNA synthetase (mitochondrial)(putative)	39					prolyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|proline-tRNA ligase activity			ovary(2)	2					L-Proline(DB00172)	CAGCAGCAGGCGCCGCCCTCT	0.522													4	20					0	0	0	0	T	55224719	T	T	55224719	3	4	18	1	0	0	0	0	1	0	0	0	11521	768	27	1	1315	1	PARS2	1	55224719	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	16761193	55224719	194025902	7	4043											
SGIP1	84251	broad.mit.edu	37	chr1	67154866	67154866	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcgaccagccactcctttgGttccttgcagaagtaccact	8	11	7	15	1	0	1	0	0	0	1	3	2	2	1	5	1	3	3	5	1	2	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:67154866G>C	uc001dcr.2	+	16	1568	c.1351G>C	c.(1351-1353)GTT>CTT	p.V451L	SGIP1_uc010opd.1_Missense_Mutation_p.V51L|SGIP1_uc001dcs.2_Missense_Mutation_p.V51L|SGIP1_uc001dct.2_Missense_Mutation_p.V51L|SGIP1_uc009wat.2_Missense_Mutation_p.V245L	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	451	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						CACTCCTTTGGTTCCTTGCAG	0.532													87	159					0	0	0	0	C	67154866	C	C	67154866	3	2	18	1	0	0	0	0	1	0	0	0	14271	1261	44	4	1413	4	SGIP1	1	67154866	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	11930147	67154866	182095755	8	4044											
OVGP1	5016	broad.mit.edu	37	chr1	111957388	111957388	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggtgactgatatgtttcTggaggggacagtcacctttt	8	13	14	6	0	2	2	1	2	1	0	2	4	2	4	1	5	0	1	1	5	1	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:111957388T>C	uc001eba.2	-	11	1791	c.1735A>G	c.(1735-1737)AGA>GGA	p.R579G	OVGP1_uc001eaz.2_Missense_Mutation_p.R541G|OVGP1_uc010owb.1_Missense_Mutation_p.R227G	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	579					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		GATATGTTTCTGGAGGGGACA	0.522													34	61					0	0	0	0	C	111957388	C	C	111957388	3	2	18	1	0	0	0	0	1	0	0	0	11379	1588	55	5	305	5	OVGP1	1	111957388	Missense_Mutation	SNP	T	TCGA-BA-6871-01A-11D-1870-08	44802522	111957388	137293233	9	4045											
TBX15	6913	broad.mit.edu	37	chr1	119474283	119474283	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atttcagttccaatatcatgGaaccgcttccagaggtcagc	11	11	8	11	1	3	1	3	0	0	1	5	2	5	2	3	2	2	2	3	2	3	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:119474283G>A	uc001ehl.1	-	2	375	c.60C>T	c.(58-60)TTC>TTT	p.F20F		NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	126	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CAATATCATGGAACCGCTTCC	0.507													19	32					0	0	0	0	A	119474283	A	A	119474283	2	1	18	1	0	0	0	0	0	0	0	1	15718	1165	41	2		2	TBX15	1	119474283	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	7516895	119474283	129776338	10	4046											
ZBTB7B	51043	broad.mit.edu	37	chr1	154987574	154987574	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attctgcagggcagtgggctAgaagctcccagcccggacga	9	6	14	12	2	1	1	0	0	1	1	2	3	2	2	2	3	3	4	2	3	2	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:154987574A>C	uc001fgk.3	+	3	596	c.438A>C	c.(436-438)CTA>CTC	p.L146L	ZBTB7B_uc009wpa.2_Silent_p.L146L|ZBTB7B_uc001fgj.3_Silent_p.L180L|ZBTB7B_uc010peq.1_Silent_p.L180L|ZBTB7B_uc001fgl.3_Silent_p.L146L	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	146					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCAGTGGGCTAGAAGCTCCCA	0.627													53	28					0	0	0	0	C	154987574	C	C	154987574	2	2	18	1	0	0	0	0	0	0	0	1	17621	407	15	5		5	ZBTB7B	1	154987574	Silent	SNP	A	TCGA-BA-6871-01A-11D-1870-08	35513291	154987574	94263047	11	4047											
KIFAP3	22920	broad.mit.edu	37	chr1	169923234	169923234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgggacttatggctccttCagaggcaattaatccatcta	11	12	8	10	1	2	1	1	0	1	1	5	2	4	2	2	3	0	2	2	3	4	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:169923234C>T	uc001ggv.2	-	19	2462	c.2191G>A	c.(2191-2193)GAA>AAA	p.E731K	KIFAP3_uc010plx.1_Missense_Mutation_p.E433K	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	731					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATGGCTCCTTCAGAGGCAATT	0.358													41	186					0	0	0	0	T	169923234	T	T	169923234	3	4	18	1	0	0	0	0	1	0	0	0	8350	835	29	2	195	2	KIFAP3	1	169923234	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	14935660	169923234	79327387	12	4048											
GPR25	2848	broad.mit.edu	37	chr1	200843070	200843070	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccttcgtcaacagctgcgCcaacccgctcatctacctcc	7	8	7	19	3	3	0	2	0	1	0	5	0	4	0	5	1	5	2	5	1	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:200843070C>G	uc001gvn.1	+	1	905	c.905C>G	c.(904-906)GCC>GGC	p.A302G		NM_005298	NP_005289	O00155	GPR25_HUMAN	G protein-coupled receptor 25	302	Helical; Name=7; (Potential).					integral to plasma membrane				ovary(1)	1						AACAGCTGCGCCAACCCGCTC	0.731													9	88					0	0	0	0	G	200843070	G	G	200843070	3	3	18	1	0	0	0	0	1	0	0	0	6721	739	26	4	907	4	GPR25	1	200843070	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	30919836	200843070	48407551	13	4049											
TMEM81	388730	broad.mit.edu	37	chr1	205052694	205052694	+	Frame_Shift_Del	DEL	C	-	-																															gaagctgtcactgctgcaggCccccccttagcgcacagagg																										TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:205052694delC	uc001hbt.2	-	1	895	c.755delG	c.(754-756)GGCfs	p.G252fs		NM_203376	NP_976310	Q6P7N7	TMM81_HUMAN	transmembrane protein 81 precursor	252	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			CTGCTGCAGGCCCCCCCTTAG	0.537													---	---	---								-	205052694	-	-	205052694	7	5	18	1	0	1	0	1	0	0	0	0	16271	739	26	0	16	0	TMEM81	1	205052694	Frame_Shift_Del	DEL	C	TCGA-BA-6871-01A-11D-1870-08	4209624	205052694	44197927	14	4050											
USH2A	7399	broad.mit.edu	37	chr1	215824103	215824103	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccggttctgcaccatgtcCagctactgggggcttttcct	4	12	11	14	1	1	0	0	0	1	0	3	0	3	0	4	3	3	4	4	3	1	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:215824103C>T	uc001hku.1	-	65	14561	c.14174G>A	c.(14173-14175)TGG>TAG	p.W4725*		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4725	Fibronectin type-III 32.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCACCATGTCCAGCTACTGGG	0.522										HNSCC(13;0.011)			62	263					0	0	0	0	T	215824103	T	T	215824103	4	4	18	1	0	0	0	0	0	1	0	0	17104	595	21	4	1466	4	USH2A	1	215824103	Nonsense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	10771409	215824103	33426518	15	4051											
USH2A	7399	broad.mit.edu	37	chr1	215940058	215940058	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagtgtctgacctagaaaaGgctcgcttgaagtgcaccca	11	8	11	11	1	1	3	0	2	1	1	2	3	1	3	2	1	1	4	2	1	4	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr1:215940058G>A	uc001hku.1	-	56	11399	c.11012C>T	c.(11011-11013)CCT>CTT	p.P3671L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3671	Extracellular (Potential).|Fibronectin type-III 21.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACCTAGAAAAGGCTCGCTTGA	0.438										HNSCC(13;0.011)			168	23					0	0	0	0	A	215940058	A	A	215940058	3	1	18	1	0	0	0	0	1	0	0	0	17104	1000	35	4	4664	4	USH2A	1	215940058	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	115955	215940058	33310563	16	4052											
TPO	7173	broad.mit.edu	37	chr2	1460007	1460007	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccttcgggggaggggctGactgccagatgacttgtgag	6	9	17	9	1	0	4	0	3	0	1	1	5	0	5	2	4	2	1	2	4	0	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:1460007G>C	uc002qww.2	+	7	863	c.772G>C	c.(772-774)GAC>CAC	p.D258H	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.D258H|TPO_uc002qwr.2_Missense_Mutation_p.D258H|TPO_uc002qwx.2_Missense_Mutation_p.D258H|TPO_uc010yio.1_Missense_Mutation_p.D258H|TPO_uc010yip.1_Missense_Mutation_p.D258H	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	258	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGAGGGGCTGACTGCCAGAT	0.463													9	40					0	0	0	0	C	1460007	C	C	1460007	3	2	18	1	0	0	0	0	1	0	0	0	16477	1290	45	2	794	2	TPO	2	1460007	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08		1460007	241739366	17	4053											
ALMS1	7840	broad.mit.edu	37	chr2	73716878	73716878	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctgaacatccacaactaGatagacacccttgtgctttc	11	12	5	13	0	1	3	0	1	1	2	3	3	2	3	2	0	3	1	2	0	4	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:73716878G>C	uc002sje.1	+	12	7906	c.7795G>C	c.(7795-7797)GAT>CAT	p.D2599H	ALMS1_uc002sjf.1_Missense_Mutation_p.D2555H|ALMS1_uc002sjg.2_Missense_Mutation_p.D1985H|ALMS1_uc002sjh.1_Missense_Mutation_p.D1985H	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2597					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TCCACAACTAGATAGACACCC	0.473													13	46					0	0	0	0	C	73716878	C	C	73716878	3	2	18	1	0	0	0	0	1	0	0	0	535	942	33	2	7827	2	ALMS1	2	73716878	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	72256871	73716878	169482495	18	4054											
CTNNA2	1496	broad.mit.edu	37	chr2	80085146	80085146	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctgtcttccaggtgagacGatgcggatcgcctcctccga	6	10	12	13	4	2	1	0	1	2	1	6	5	5	2	4	2	1	0	4	2	0	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:80085146G>A	uc010ysh.1	+	3	311	c.306G>A	c.(304-306)ACG>ACA	p.T102T	CTNNA2_uc010yse.1_Silent_p.T102T|CTNNA2_uc010ysf.1_Silent_p.T102T|CTNNA2_uc010ysg.1_Silent_p.T102T	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	102					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CAGGTGAGACGATGCGGATCG	0.552													28	87					0	0	0	0	A	80085146	A	A	80085146	2	1	18	1	0	0	0	0	0	0	0	1	4030	1045	37	1		1	CTNNA2	2	80085146	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	6368268	80085146	163114227	19	4055											
KDM3A	55818	broad.mit.edu	37	chr2	86716520	86716520	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgcagctaatgtcatggtCtatgtgggaattcccaaagg	11	11	12	7	0	2	0	1	0	1	0	3	2	3	1	1	3	2	2	1	3	4	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:86716520C>G	uc002sri.3	+	22	3720	c.3393C>G	c.(3391-3393)GTC>GTG	p.V1131V	KDM3A_uc010ytj.1_Silent_p.V1131V|KDM3A_uc010ytk.1_Silent_p.V1079V	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	1131	JmjC.				androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						ATGTCATGGTCTATGTGGGAA	0.428													20	43					0	0	0	0	G	86716520	G	G	86716520	2	3	18	1	0	0	0	0	0	0	0	1	8165	900	32	2		2	KDM3A	2	86716520	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08	6631374	86716520	156482853	20	4056											
MYO7B	4648	broad.mit.edu	37	chr2	128394476	128394476	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtggcagccgcctgctgtgCgagacctccctggtgagctc	4	8	14	15	3	0	2	0	1	0	1	2	3	1	2	4	2	4	3	4	2	0	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:128394476C>A	uc002top.2	+	46	6290	c.6237C>A	c.(6235-6237)TGC>TGA	p.C2079*	MYO7B_uc002tos.1_Nonsense_Mutation_p.C189*|MYO7B_uc002tot.2_Nonsense_Mutation_p.C189*	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	2079	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GCCTGCTGTGCGAGACCTCCC	0.612													3	40					0.004672	0.00487964	1	0	A	128394476	A	A	128394476	4	1	18	1	0	0	0	0	0	1	0	0	10136	776	27	3	6415	3	MYO7B	2	128394476	Nonsense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	41677956	128394476	114804897	21	4057											
THSD7B	80731	broad.mit.edu	37	chr2	138414381	138414381	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccaggagactgccatttaaCagaatggtcagagtggagca	13	8	12	8	0	1	3	1	0	0	3	2	5	2	4	2	3	3	1	2	3	2	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:138414381C>G	uc002tva.1	+	22	4034	c.4034C>G	c.(4033-4035)ACA>AGA	p.T1345R	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGCCATTTAACAGAATGGTCA	0.473													5	32					0	0	0	0	G	138414381	G	G	138414381	3	3	18	1	0	0	0	0	1	0	0	0	15946	478	17	4	4119	4	THSD7B	2	138414381	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	10019905	138414381	104784992	22	4058											
LRP1B	53353	broad.mit.edu	37	chr2	141032089	141032089	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attttggtccttcatagcgcGttggacagacacattcaaca	11	12	8	10	2	2	1	2	0	0	1	3	2	3	2	1	2	2	1	1	2	2	6			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:141032089G>A	uc002tvj.1	-	85	14018	c.13046C>T	c.(13045-13047)ACG>ATG	p.T4349M		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4349	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCATAGCGCGTTGGACAGAC	0.423										TSP Lung(27;0.18)			17	32					0	0	0	0	A	141032089	A	A	141032089	3	1	18	1	0	0	0	0	1	0	0	0	9005	1145	40	1	781	1	LRP1B	2	141032089	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	2617708	141032089	102167284	23	4059											
LRP1B	53353	broad.mit.edu	37	chr2	141116452	141116452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcccattgcacatttgctccGactgtaggcatattctgtta	8	15	7	11	1	1	0	0	0	1	0	3	1	3	0	2	1	2	5	2	1	3	6			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:141116452G>A	uc002tvj.1	-	73	12167	c.11195C>T	c.(11194-11196)TCG>TTG	p.S3732L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3732	Extracellular (Potential).|LDL-receptor class A 31.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATTTGCTCCGACTGTAGGCA	0.388										TSP Lung(27;0.18)			34	42					0	0	0	0	A	141116452	A	A	141116452	3	1	18	1	0	0	0	0	1	0	0	0	9005	1059	37	1	2680	1	LRP1B	2	141116452	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	84363	141116452	102082921	24	4060											
TTN	7273	broad.mit.edu	37	chr2	179439600	179439600	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttattggtacaccaccatcGttctcaggtgggtcccaaga	9	11	9	12	1	1	1	1	0	1	1	4	1	2	1	3	3	1	2	3	3	3	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:179439600G>A	uc010zfg.1	-	275	63779	c.63555C>T	c.(63553-63555)AAC>AAT	p.N21185N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.N14880N|TTN_uc010zfi.1_Silent_p.N14813N|TTN_uc010zfj.1_Silent_p.N14688N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22112							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACCACCATCGTTCTCAGGTG	0.448													4	17					0	0	0	0	A	179439600	A	A	179439600	2	1	18	1	0	0	0	0	0	0	0	1	16803	1136	40	1		1	TTN	2	179439600	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	38323148	179439600	63759773	25	4061											
ZSWIM2	151112	broad.mit.edu	37	chr2	187712479	187712479	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacaaagttcccctcctttcGgaaatgtggaacagttacaa	13	11	7	10	1	0	0	0	0	0	0	3	2	2	2	3	2	3	2	3	2	6	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:187712479G>A	uc002upu.1	-	2	249	c.209C>T	c.(208-210)CCG>CTG	p.P70L		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	70	SWIM-type.				apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			CCCTCCTTTCGGAAATGTGGA	0.348													25	35					0	0	0	0	A	187712479	A	A	187712479	3	1	18	1	0	0	0	0	1	0	0	0	18308	1116	39	1	1724	1	ZSWIM2	2	187712479	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	8272879	187712479	55486894	26	4062											
FAM119A	151194	broad.mit.edu	37	chr2	208478045	208478045	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggagaaaaactccccaaatTttgtccccaagtcagctcct	13	9	6	13	0	1	1	1	0	0	1	4	2	4	1	5	1	2	1	5	1	4	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:208478045T>G	uc002vcf.2	-	4	542	c.382A>C	c.(382-384)AAT>CAT	p.N128H	FAM119A_uc002vce.2_Intron|FAM119A_uc010fuk.1_Missense_Mutation_p.N128H|FAM119A_uc002vcg.3_Missense_Mutation_p.N128H	NM_145280	NP_660323	Q8WXB1	MT21A_HUMAN	hypothetical protein LOC151194	128						integral to membrane	methyltransferase activity				0				LUSC - Lung squamous cell carcinoma(261;0.0705)|Epithelial(149;0.131)|Lung(261;0.135)		CTCCCCAAATTTTGTCCCCAA	0.368													24	33					0	0	0	0	G	208478045	G	G	208478045	3	3	18	1	0	0	0	0	1	0	0	0	5441	1841	64	5	278	5	FAM119A	2	208478045	Missense_Mutation	SNP	T	TCGA-BA-6871-01A-11D-1870-08	20765566	208478045	34721328	27	4063											
KIAA1486	57624	broad.mit.edu	37	chr2	226447438	226447438	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taccctaaaagtcactccacCtctccctcccccgtcagcat	9	9	3	20	1	3	0	2	0	1	0	6	0	5	0	6	0	2	1	6	0	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:226447438C>T	uc002voe.2	+	4	1480	c.1305C>T	c.(1303-1305)ACC>ACT	p.T435T	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Silent_p.T205T	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	435	Pro-rich.									ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GTCACTCCACCTCTCCCTCCC	0.647													9	12					0	0	0	0	T	226447438	T	T	226447438	2	4	18	1	0	0	0	0	0	0	0	1	8276	668	24	4		4	KIAA1486	2	226447438	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08	17969393	226447438	16751935	28	4064											
ALPPL2	251	broad.mit.edu	37	chr2	233272041	233272041	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccaggatcctaaaagggcAgaagaaggacaaactggggc	15	4	14	8	0	0	2	0	0	0	2	1	4	1	4	2	5	2	1	2	5	5	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:233272041A>G	uc002vss.3	+	3	283	c.230A>G	c.(229-231)CAG>CGG	p.Q77R		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	77					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CTAAAAGGGCAGAAGAAGGAC	0.587													17	36					0	0	0	0	G	233272041	G	G	233272041	3	3	18	1	0	0	0	0	1	0	0	0	549	188	7	5	240	5	ALPPL2	2	233272041	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	6824603	233272041	9927332	29	4065											
CHRNG	1146	broad.mit.edu	37	chr2	233410382	233410382	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acaaccgggtgccggccctgCcattccctggagatccacgc	7	6	11	17	3	0	1	0	0	0	1	2	2	2	1	6	3	3	0	6	3	1	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:233410382C>G	uc002vsx.1	+	12	1531	c.1510C>G	c.(1510-1512)CCA>GCA	p.P504A	CHRNG_uc010fye.1_Missense_Mutation_p.P452A	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	504					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		GCCGGCCCTGCCATTCCCTGG	0.617													17	43					0	0	0	0	G	233410382	G	G	233410382	3	3	18	1	0	0	0	0	1	0	0	0	3411	739	26	4	1556	4	CHRNG	2	233410382	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	138341	233410382	9788991	30	4066											
ATG16L1	55054	broad.mit.edu	37	chr2	234202923	234202923	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatccatcaatgcggtggCgtggtcgccctctggctcgc	4	10	12	15	4	3	0	2	0	1	0	6	0	4	0	2	4	1	1	2	4	1	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:234202923C>T	uc002vty.2	+	18	2008	c.1751C>T	c.(1750-1752)GCG>GTG	p.A584V	ATG16L1_uc002vtx.1_Missense_Mutation_p.A421V|ATG16L1_uc002vua.2_Missense_Mutation_p.A565V|ATG16L1_uc002vub.2_Missense_Mutation_p.A442V|ATG16L1_uc002vtz.2_Missense_Mutation_p.A405V|ATG16L1_uc002vud.3_Missense_Mutation_p.A500V	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	584	WD 7.				autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		AATGCGGTGGCGTGGTCGCCC	0.537													14	25					0	0	0	0	T	234202923	T	T	234202923	3	4	18	1	0	0	0	0	1	0	0	0	1093	768	27	1	1821	1	ATG16L1	2	234202923	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	792541	234202923	8996450	31	4067											
UGT1A7	54577	broad.mit.edu	37	chr2	234591112	234591112	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggaatattttgccactatCttgaagaaggtgcacagtgc	11	11	12	7	0	1	2	0	1	1	1	1	3	1	3	1	3	3	1	1	3	5	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr2:234591112C>G	uc002vut.2	+	1	529	c.529C>G	c.(529-531)CTT>GTT	p.L177V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Missense_Mutation_p.L177V	NM_019077	NP_061950	Q9HAW7	UD17_HUMAN	UDP glycosyltransferase 1 family, polypeptide A7	177					drug metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	drug binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TTGCCACTATCTTGAAGAAGG	0.483													56	100					0	0	0	0	G	234591112	G	G	234591112	3	3	18	1	0	0	0	0	1	0	0	0	17018	913	32	2	531	2	UGT1A7	2	234591112	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	388189	234591112	8608261	32	4068											
DOCK3	1795	broad.mit.edu	37	chr3	51317591	51317591	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccagatgtgtgacacccatTtccagcacctcctggacaac	10	8	8	15	0	0	2	0	1	0	1	2	3	2	3	5	1	2	1	5	1	1	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:51317591T>C	uc011bds.1	+	27	2901	c.2878T>C	c.(2878-2880)TTC>CTC	p.F960L		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	960						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGACACCCATTTCCAGCACCT	0.532													10	17					0	0	0	0	C	51317591	C	C	51317591	3	2	18	1	0	0	0	0	1	0	0	0	4710	1841	64	5	2984	5	DOCK3	3	51317591	Missense_Mutation	SNP	T	TCGA-BA-6871-01A-11D-1870-08		51317591	146704839	33	4069											
FAM116A	201627	broad.mit.edu	37	chr3	57658127	57658127	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagcagtatttttacttacTtctctgtcagtaagtttgga	10	17	8	6	0	2	1	1	0	1	1	3	2	2	2	0	1	3	4	0	1	4	8			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:57658127T>C	uc003dja.2	-	2	347	c.276A>G	c.(274-276)GAA>GAG	p.E92E		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	92										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		TTTTACTTACTTCTCTGTCAG	0.234													39	13					0	0	0	0	C	57658127	C	C	57658127	2	2	18	1	0	0	0	0	0	0	0	1	5435	1623	56	5		5	FAM116A	3	57658127	Silent	SNP	T	TCGA-BA-6871-01A-11D-1870-08	6340536	57658127	140364303	34	4070											
ROBO2	6092	broad.mit.edu	37	chr3	77600053	77600053	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctcacaatcaccaacattCaacgttccgacgcgggttac	12	8	6	15	4	3	0	3	0	0	0	4	1	4	0	3	1	3	2	3	1	4	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:77600053C>G	uc003dpy.3	+	8	1787	c.1144C>G	c.(1144-1146)CAA>GAA	p.Q382E	ROBO2_uc003dpz.2_Missense_Mutation_p.Q386E|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.Q386E	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	382	Ig-like C2-type 4.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CACCAACATTCAACGTTCCGA	0.488													16	34					0	0	0	0	G	77600053	G	G	77600053	3	3	18	1	0	0	0	0	1	0	0	0	13579	827	29	2	1176	2	ROBO2	3	77600053	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	19941926	77600053	120422377	35	4071											
SLC15A2	6565	broad.mit.edu	37	chr3	121646672	121646672	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcagttgcggcagctgtaGagataaaaataaatgtgagt	14	11	12	4	1	0	2	0	1	0	1	0	3	0	2	0	1	3	5	0	1	6	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:121646672G>C	uc003eep.2	+	14	1345	c.1192G>C	c.(1192-1194)GAG>CAG	p.E398Q	SLC15A2_uc011bjn.1_Missense_Mutation_p.E367Q	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	398	Helical; (Potential).				protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GGCAGCTGTAGAGATAAAAAT	0.254													15	43					0	0	0	0	C	121646672	C	C	121646672	3	2	18	1	0	0	0	0	1	0	0	0	14464	943	33	2	1246	2	SLC15A2	3	121646672	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	44046619	121646672	76375758	36	4072											
DHX36	170506	broad.mit.edu	37	chr3	154022638	154022638	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcattcaatgttgcactcatCaatattactttcaagtcaga	13	14	5	9	0	5	1	5	0	0	1	5	1	5	1	0	0	2	3	0	0	5	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:154022638C>A	uc003ezy.3	-	8	1173	c.1092G>T	c.(1090-1092)TTG>TTT	p.L364F	DHX36_uc010hvq.2_Missense_Mutation_p.L364F|DHX36_uc003ezz.3_Missense_Mutation_p.L364F	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	364	Helicase ATP-binding.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTGCACTCATCAATATTACTT	0.289													10	78					0.000978159	0.00103311	1	0	A	154022638	A	A	154022638	3	1	18	1	0	0	0	0	1	0	0	0	4531	825	29	2	2006	2	DHX36	3	154022638	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	32375966	154022638	43999792	37	4073											
IFT80	57560	broad.mit.edu	37	chr3	159997002	159997002	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaacaaagcgacaaagtctCacagcatcttcccattttga	14	11	5	11	1	2	1	1	1	2	0	4	2	3	1	1	0	3	1	1	0	3	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:159997002C>G	uc011boy.1	-	16	2248	c.1815G>C	c.(1813-1815)GTG>GTC	p.V605V	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Silent_p.V468V|IFT80_uc003fdd.1_Silent_p.V288V|IFT80_uc003fde.1_Silent_p.V468V	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	605						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GACAAAGTCTCACAGCATCTT	0.343													13	117					0	0	0	0	G	159997002	G	G	159997002	2	3	18	1	0	0	0	0	0	0	0	1	7603	813	29	2		2	IFT80	3	159997002	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08	5974364	159997002	38025428	38	4074											
SMC4	10051	broad.mit.edu	37	chr3	160141353	160141353	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gataccttagtagctgacaaCttggatcaagccacaagagt	14	9	9	9	0	1	2	1	1	0	1	1	4	1	3	2	1	4	2	2	1	6	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:160141353C>G	uc003fdh.2	+	14	2273	c.2160C>G	c.(2158-2160)AAC>AAG	p.N720K	IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Missense_Mutation_p.N484K|SMC4_uc003fdi.2_Missense_Mutation_p.N695K|SMC4_uc003fdj.2_Missense_Mutation_p.N720K|SMC4_uc010hwd.2_Missense_Mutation_p.N720K|SMC4_uc003fdl.2_Missense_Mutation_p.N423K	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	720	Flexible hinge.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TAGCTGACAACTTGGATCAAG	0.343													53	389					0	0	0	0	G	160141353	G	G	160141353	3	3	18	1	0	0	0	0	1	0	0	0	14849	564	20	4	2210	4	SMC4	3	160141353	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	144351	160141353	37881077	39	4075											
SI	6476	broad.mit.edu	37	chr3	164733816	164733817	+	Frame_Shift_Ins	INS	-	T	T																															gtcctggaatgcttcaccaaINSttgtaaagtctagctgcctt																										TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:164733816_164733817insT	uc003fei.2	-	32	3873_3874	c.3811_3812insA	c.(3811-3813)ATTfs	p.I1271fs		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1271	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGCTTCACCAATTGTAAAGTCT	0.366										HNSCC(35;0.089)			---	---	---								T	164733817	T	T	164733816	7	5	18	1	0	1	1	0	0	0	0	0	14362	101	4	0	1739	0	SI	3	164733816	Frame_Shift_Ins	INS	-	TCGA-BA-6871-01A-11D-1870-08	4592463	164733816	33288614	40	4076											
SLITRK3	22865	broad.mit.edu	37	chr3	164905937	164905937	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccacaaatcccactgtgcaGggggcaggctgtggcctctc	7	8	12	14	0	1	0	0	0	1	0	4	0	3	0	3	4	1	3	3	4	1	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:164905937G>T	uc003fej.3	-	2	3126	c.2682C>A	c.(2680-2682)CCC>CCA	p.P894P	SLITRK3_uc003fek.2_Silent_p.P894P	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	894	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CCACTGTGCAGGGGGCAGGCT	0.552										HNSCC(40;0.11)			44	59					1.7489e-18	2.01714e-18	1	0	T	164905937	T	T	164905937	2	4	18	1	0	0	0	0	0	0	0	1	14808	987	35	4		4	SLITRK3	3	164905937	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	172121	164905937	33116493	41	4077											
ZNF639	51193	broad.mit.edu	37	chr3	179052100	179052100	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaagatcttaaaattcatCtagatttcaagcattcagct	14	15	5	7	0	5	3	3	1	2	2	5	3	5	3	0	0	2	2	0	0	5	6			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:179052100C>G	uc003fjq.1	+	6	1691	c.1348C>G	c.(1348-1350)CTA>GTA	p.L450V	ZNF639_uc003fjr.1_Missense_Mutation_p.L450V	NM_016331	NP_057415	Q9UID6	ZN639_HUMAN	zinc finger protein 639	450	Interaction with CTNNA2.|C2H2-type 7.				initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TAAAATTCATCTAGATTTCAA	0.323													32	162					0	0	0	0	G	179052100	G	G	179052100	3	3	18	1	0	0	0	0	1	0	0	0	18123	912	32	2	1362	2	ZNF639	3	179052100	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	14146163	179052100	18970330	42	4078											
YEATS2	55689	broad.mit.edu	37	chr3	183493712	183493712	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtatttttagatctccagtCtggctcagctgccagtggtg	6	15	11	9	0	3	1	1	0	2	1	4	1	3	1	2	2	2	3	2	2	2	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:183493712C>G	uc003fly.2	+	18	2573	c.2378C>G	c.(2377-2379)TCT>TGT	p.S793C	YEATS2_uc003flz.2_5'UTR	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	793					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GATCTCCAGTCTGGCTCAGCT	0.279													20	146					0	0	0	0	G	183493712	G	G	183493712	3	3	18	1	0	0	0	0	1	0	0	0	17540	913	32	2	2444	2	YEATS2	3	183493712	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	4441612	183493712	14528718	43	4079											
CHRD	8646	broad.mit.edu	37	chr3	184102418	184102418	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcaccaaggacttcccaGacggagagcttcgggggcac	9	5	15	12	2	0	2	0	0	0	2	2	4	1	3	2	5	1	3	2	5	1	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:184102418G>T	uc003fov.2	+	13	1780	c.1534G>T	c.(1534-1536)GAC>TAC	p.D512Y	CHRD_uc003fow.2_Missense_Mutation_p.D142Y|CHRD_uc003fox.2_Missense_Mutation_p.D512Y|CHRD_uc003foy.2_Missense_Mutation_p.D142Y|CHRD_uc010hyc.2_Missense_Mutation_p.D102Y|CHRD_uc011brr.1_Missense_Mutation_p.D142Y	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	512	CHRD 3.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGACTTCCCAGACGGAGAGCT	0.637													23	90					1.50039e-11	1.68906e-11	1	0	T	184102418	T	T	184102418	3	4	18	1	0	0	0	0	1	0	0	0	3387	942	33	2	1584	2	CHRD	3	184102418	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	608706	184102418	13920012	44	4080											
PAK2	5062	broad.mit.edu	37	chr3	196530019	196530019	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagtgaagcagaaatatctGagctttactcctcctggtaa	13	11	8	9	0	1	3	0	2	1	1	3	3	3	3	2	1	3	3	2	1	5	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr3:196530019G>C	uc003fwy.3	+	4	742	c.420G>C	c.(418-420)CTG>CTC	p.L140L		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	140					axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		AGAAATATCTGAGCTTTACTC	0.418													16	113					0	0	0	0	C	196530019	C	C	196530019	2	2	18	1	0	0	0	0	0	0	0	1	11455	1277	45	2		2	PAK2	3	196530019	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	12427601	196530019	1492411	45	4081											
KIT	3815	broad.mit.edu	37	chr4	55594190	55594190	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attttagcgagtgcccatttGacagaacgggaagccctcat	11	10	10	10	2	1	2	1	1	0	1	1	4	1	3	2	1	4	0	2	1	3	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr4:55594190G>C	uc010igr.2	+	13	1980	c.1893G>C	c.(1891-1893)TTG>TTC	p.L631F	KIT_uc010igs.2_Missense_Mutation_p.L627F|KIT_uc010igt.1_Missense_Mutation_p.L80F	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	631	Protein kinase.|Cytoplasmic (Potential).				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GTGCCCATTTGACAGAACGGG	0.438		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				5	71					0	0	0	0	C	55594190	C	C	55594190	3	2	18	1	0	0	0	0	1	0	0	0	8368	1281	45	2	1943	2	KIT	4	55594190	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08		55594190	135560086	46	4082											
CENPC1	1060	broad.mit.edu	37	chr4	68385088	68385088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaacagaaggtgagccaacgGataagtaaaattcttcatca	17	8	9	7	1	3	2	2	1	1	1	3	4	3	3	1	2	3	1	1	2	6	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr4:68385088G>A	uc003hdd.1	-	6	647	c.464C>T	c.(463-465)TCC>TTC	p.S155F	CENPC1_uc010ihj.1_RNA|CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihm.1_Missense_Mutation_p.S155F	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	155					mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2						TGAGCCAACGGATAAGTAAAA	0.343													23	83					0	0	0	0	A	68385088	A	A	68385088	3	1	18	1	0	0	0	0	1	0	0	0	3244	1174	41	2	2423	2	CENPC1	4	68385088	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	12790898	68385088	122769188	47	4083											
PRDM8	56978	broad.mit.edu	37	chr4	81122461	81122461	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtagacacctcagcagcAaatggttcctcagaaggtct	12	8	10	11	0	3	2	2	0	1	2	4	2	4	2	2	3	2	4	2	3	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr4:81122461A>C	uc010ijo.2	+	7	1076	c.237A>C	c.(235-237)GCA>GCC	p.A79A	PRDM8_uc003hmb.3_Silent_p.A79A|PRDM8_uc003hmc.3_Silent_p.A79A	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	79	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CCTCAGCAGCAAATGGTTCCT	0.478													9	18					0	0	0	0	C	81122461	C	C	81122461	2	2	18	1	0	0	0	0	0	0	0	1	12524	117	5	5		5	PRDM8	4	81122461	Silent	SNP	A	TCGA-BA-6871-01A-11D-1870-08	12737373	81122461	110031815	48	4084											
PRDM8	56978	broad.mit.edu	37	chr4	81123227	81123227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcaccaaggaccacggggGcggcggcggcggtggcaaag	8	1	21	11	5	0	0	0	0	0	0	0	1	0	1	2	9	0	2	2	9	2	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr4:81123227G>A	uc010ijo.2	+	8	1450	c.611G>A	c.(610-612)GGC>GAC	p.G204D	PRDM8_uc003hmb.3_Missense_Mutation_p.G204D|PRDM8_uc003hmc.3_Missense_Mutation_p.G204D	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	204	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						gaccacgggggcggcggcggc	0.378											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	53					0	0	0	0	A	81123227	A	A	81123227	3	1	18	1	0	0	0	0	1	0	0	0	12524	1203	42	4	621	4	PRDM8	4	81123227	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	766	81123227	110031049	49	4085											
MTTP	4547	broad.mit.edu	37	chr4	100534196	100534196	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcagctcagacctgtcaccTttttcaacggatacagtgat	10	13	7	11	1	4	2	4	1	0	1	4	3	4	3	2	1	3	1	2	1	2	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr4:100534196T>C	uc003hvc.3	+	16	2372	c.2116T>C	c.(2116-2118)TTT>CTT	p.F706L	MTTP_uc011cej.1_Missense_Mutation_p.F733L	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	706					lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	ACCTGTCACCTTTTTCAACGG	0.478													3	120					0	0	0	0	C	100534196	C	C	100534196	3	2	18	1	0	0	0	0	1	0	0	0	10017	1609	56	5	2174	5	MTTP	4	100534196	Missense_Mutation	SNP	T	TCGA-BA-6871-01A-11D-1870-08	19410969	100534196	90620080	50	4086											
TBCK	93627	broad.mit.edu	37	chr4	107156504	107156504	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttgcttctttccagatttgGttttttttatatggataagc	7	21	7	6	0	1	1	0	0	1	1	2	2	2	2	1	2	2	2	1	2	3	10			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr4:107156504G>T	uc010ilv.2	-	15	1736	c.1371C>A	c.(1369-1371)AAC>AAA	p.N457K	TBCK_uc003hyb.2_Missense_Mutation_p.N200K|TBCK_uc003hye.2_Missense_Mutation_p.N418K|TBCK_uc003hyc.2_Missense_Mutation_p.N394K|TBCK_uc003hyd.2_Missense_Mutation_p.N285K|TBCK_uc003hyf.2_Missense_Mutation_p.N457K	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	457						intracellular	Rab GTPase activator activity	p.N457fs*15(1)		large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						TCCAGATTTGGTTTTTTTTAT	0.363													10	28					6.40141e-05	6.87694e-05	1	0	T	107156504	T	T	107156504	3	4	18	1	0	0	0	0	1	0	0	0	15702	1252	44	4	1358	4	TBCK	4	107156504	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	6622308	107156504	83997772	51	4087											
ANK2	287	broad.mit.edu	37	chr4	114275313	114275313	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaaggcaccctccagtatcaCcatcaagtaaaactgagaaa	18	6	6	11	0	2	1	2	1	0	1	3	2	3	1	3	1	1	3	3	1	6	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr4:114275313C>A	uc003ibe.3	+	38	5639	c.5539C>A	c.(5539-5541)CCA>ACA	p.P1847T	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.P1862T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1814	Repeat A.|Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCCAGTATCACCATCAAGTAA	0.473													56	179					2.5401e-28	2.98461e-28	1	0	A	114275313	A	A	114275313	3	1	18	1	0	0	0	0	1	0	0	0	621	507	18	4	5754	4	ANK2	4	114275313	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	7118809	114275313	76878963	52	4088											
KIAA1109	84162	broad.mit.edu	37	chr4	123270379	123270379	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtaatcgtgatcgagagatCagcatgtctgttggtctggg	9	12	14	6	2	3	2	1	1	2	1	5	4	3	2	0	2	1	3	0	2	1	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr4:123270379C>T	uc003ieh.2	+	76	13392	c.13347C>T	c.(13345-13347)ATC>ATT	p.I4449I	KIAA1109_uc003iem.2_Silent_p.I805I	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4449					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						ATCGAGAGATCAGCATGTCTG	0.403													12	37					0	0	0	0	T	123270379	T	T	123270379	2	4	18	1	0	0	0	0	0	0	0	1	8247	816	29	2		2	KIAA1109	4	123270379	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08	8995066	123270379	67883897	53	4089											
ZNF827	152485	broad.mit.edu	37	chr4	146823888	146823888	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcattctgttcctgcttctCggccaacttcctggccagaa	6	13	8	14	1	3	1	1	0	2	1	6	1	5	1	4	2	2	2	4	2	2	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr4:146823888C>T	uc003ikn.2	-	2	571	c.523G>A	c.(523-525)GAG>AAG	p.E175K	ZNF827_uc003ikm.2_Missense_Mutation_p.E175K|ZNF827_uc010iox.2_Intron	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					TCCTGCTTCTCGGCCAACTTC	0.537													4	93					0	0	0	0	T	146823888	T	T	146823888	3	4	18	1	0	0	0	0	1	0	0	0	18247	893	31	1	2758	1	ZNF827	4	146823888	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	23553509	146823888	44330388	54	4090											
FAT1	2195	broad.mit.edu	37	chr4	187535482	187535482	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggacgtcttcaggaataGtgtctgaatataaagtctgc	13	11	11	6	1	4	1	1	1	3	0	4	4	4	3	0	2	1	0	0	2	7	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr4:187535482G>A	uc003izf.2	-	12	9280	c.9092C>T	c.(9091-9093)ACT>ATT	p.T3031I		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3031	Extracellular (Potential).|Cadherin 28.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTCAGGAATAGTGTCTGAATA	0.378										HNSCC(5;0.00058)			19	56					0	0	0	0	A	187535482	A	A	187535482	3	1	18	1	0	0	0	0	1	0	0	0	5721	1029	36	4	4738	4	FAT1	4	187535482	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	40711594	187535482	3618794	55	4091											
TERT	7015	broad.mit.edu	37	chr5	1253933	1253933	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccgggagcttccgactCagctgcgtctgggctgcggg	3	8	16	14	4	2	0	1	0	1	0	4	2	4	1	3	3	4	3	3	3	0	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr5:1253933C>A	uc003jcb.1	-	16	3367	c.3309G>T	c.(3307-3309)CTG>CTT	p.L1103L	TERT_uc003jbz.1_Silent_p.L299L|TERT_uc003jca.1_Silent_p.L1091L|TERT_uc003jcc.1_Silent_p.L1040L|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	1103	CTE.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCTTCCGACTCAGCTGCGTCT	0.662									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				13	133					1.3612e-06	1.48783e-06	1	0	A	1253933	A	A	1253933	2	1	18	1	0	0	0	0	0	0	0	1	15830	813	29	2		2	TERT	5	1253933	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08		1253933	179661327	56	4092											
C5orf23	79614	broad.mit.edu	37	chr5	32789781	32789781	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcacatgtgccttctttgcCccaaatgcatcactttcctt	7	14	6	14	0	2	0	1	0	1	0	3	0	3	0	4	1	3	2	4	1	1	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr5:32789781C>A	uc003jhw.1	+	1	837	c.274C>A	c.(274-276)CCC>ACC	p.P92T		NM_024563	NP_078839			hypothetical protein LOC79614												0						CCTTCTTTGCCCCAAATGCAT	0.403													18	41					1.67942e-08	1.85724e-08	1	0	A	32789781	A	A	32789781	3	1	18	1	0	0	0	0	1	0	0	0	2296	623	22	4	276	4	C5orf23	5	32789781	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	31535848	32789781	148125479	57	4093											
REEP5	7905	broad.mit.edu	37	chr5	112238181	112238181	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaggtcagccactgggtatCatcttctttgttgggactct	6	15	11	9	0	5	0	2	0	3	0	5	1	5	1	1	3	1	3	1	3	2	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr5:112238181C>T	uc003kqe.1	-	3	391	c.247G>A	c.(247-249)GAT>AAT	p.D83N	REEP5_uc011cvw.1_Missense_Mutation_p.D56N|REEP5_uc011cvx.1_RNA|REEP5_uc011cvy.1_Missense_Mutation_p.D83N|REEP5_uc011cvz.1_Intron	NM_005669	NP_005660	Q00765	REEP5_HUMAN	receptor accessory protein 5	83						integral to membrane	protein binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		Epithelial(69;1.3e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.26e-08)|all cancers(49;3.56e-07)|Colorectal(14;0.00778)|COAD - Colon adenocarcinoma(37;0.013)		CACTGGGTATCATCTTCTTTG	0.383													16	48					0	0	0	0	T	112238181	T	T	112238181	3	4	18	1	0	0	0	0	1	0	0	0	13273	826	29	2	334	2	REEP5	5	112238181	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	79448400	112238181	68677079	58	4094											
FBN2	2201	broad.mit.edu	37	chr5	127595471	127595471	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgggagaggttgaacttCatgttgacggggctgtccat	8	11	16	6	1	1	3	1	2	0	1	2	4	2	3	1	5	1	3	1	5	1	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr5:127595471C>T	uc003kuu.2	-	65	8854	c.8415G>A	c.(8413-8415)ATG>ATA	p.M2805I		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2805					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGTTGAACTTCATGTTGACGG	0.517													47	44					0	0	0	0	T	127595471	T	T	127595471	3	4	18	1	0	0	0	0	1	0	0	0	5735	826	29	2	327	2	FBN2	5	127595471	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	15357290	127595471	53319789	59	4095											
KCTD16	57528	broad.mit.edu	37	chr5	143586683	143586683	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcccagatgaattctgcCacagtgactttgaagatgcc	13	9	9	10	0	1	5	0	3	1	2	1	5	1	5	3	0	3	0	3	0	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr5:143586683C>G	uc003lnm.1	+	3	1035	c.406C>G	c.(406-408)CAC>GAC	p.H136D	KCTD16_uc003lnn.1_Missense_Mutation_p.H136D	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	136						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TGAATTCTGCCACAGTGACTT	0.522													28	43					0	0	0	0	G	143586683	G	G	143586683	3	3	18	1	0	0	0	0	1	0	0	0	8142	594	21	4	408	4	KCTD16	5	143586683	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	15991212	143586683	37328577	60	4096											
THG1L	54974	broad.mit.edu	37	chr5	157166327	157166327	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actactttatttttacctgtAggtggatgaagtgatgacaa	12	15	9	5	0	0	3	0	3	0	0	0	4	0	4	1	2	2	1	1	2	6	7			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr5:157166327A>T	uc003lxd.2	+	6	862	c.736_splice	c.e6-2	p.V246_splice	THG1L_uc011ddu.1_Splice_Site_p.V114_splice	NM_017872	NP_060342	Q9NWX6	THG1_HUMAN	interphase cytoplasmic foci protein 45						protein homotetramerization|tRNA modification	mitochondrion	GTP binding|metal ion binding|tRNA guanylyltransferase activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTTACCTGTAGGTGGATGAA	0.428													17	26					0	0	0	0	T	157166327	T	T	157166327	5	4	18	1	0	0	0	0	0	0	1	0	15927	434	15	5	756	5	THG1L	5	157166327	Splice_Site	SNP	A	TCGA-BA-6871-01A-11D-1870-08	13579644	157166327	23748933	61	4097											
TRIM26	7726	broad.mit.edu	37	chr6	30166498	30166498	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgtggggcctgtgctccCgggactcccggcacatcacg	4	7	14	16	4	1	0	1	0	0	0	3	1	3	1	4	4	1	2	4	4	0	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr6:30166498C>G	uc003npr.2	-	3	592	c.383G>C	c.(382-384)CGG>CCG	p.R128P	TRIM26_uc003nps.2_Missense_Mutation_p.R128P|TRIM26_uc010jry.2_5'UTR|TRIM26_uc003npt.2_Missense_Mutation_p.R128P|TRIM26_uc003npu.1_Missense_Mutation_p.R128P	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	128	B box-type.						DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CCTGTGCTCCCGGGACTCCCG	0.642													11	14					0	0	0	0	G	30166498	G	G	30166498	3	3	18	1	0	0	0	0	1	0	0	0	16567	652	23	3	1264	3	TRIM26	6	30166498	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08		30166498	140948569	62	4098											
ANKS1A	23294	broad.mit.edu	37	chr6	34949518	34949518	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcgcagtatggccacacaGaggtggtgaaggtgctctta	10	8	14	9	1	1	2	0	1	1	1	1	2	1	2	1	4	2	3	1	4	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr6:34949518G>C	uc003ojx.3	+	4	629	c.487G>C	c.(487-489)GAG>CAG	p.E163Q	ANKS1A_uc011dss.1_Missense_Mutation_p.E163Q|ANKS1A_uc011dst.1_5'UTR|ANKS1A_uc010jvp.1_5'UTR|ANKS1A_uc010jvr.1_RNA	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	163	ANK 3.					cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						TGGCCACACAGAGGTGGTGAA	0.542													21	41					0	0	0	0	C	34949518	C	C	34949518	3	2	18	1	0	0	0	0	1	0	0	0	688	943	33	2	501	2	ANKS1A	6	34949518	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	4783020	34949518	136165549	63	4099											
ZFAND3	60685	broad.mit.edu	37	chr6	38120124	38120124	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgaagctggaccggaaaGtggggcgctcctgccagcgc	7	6	17	11	3	0	1	0	1	0	0	1	3	1	3	3	5	3	2	3	5	2	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr6:38120124G>C	uc003onx.2	+	6	1058	c.643G>C	c.(643-645)GTG>CTG	p.V215L		NM_021943	NP_068762	Q9H8U3	ZFAN3_HUMAN	zinc finger, AN1-type domain 3	215							DNA binding|zinc ion binding			ovary(1)	1						GGACCGGAAAGTGGGGCGCTC	0.577													69	67					0	0	0	0	C	38120124	C	C	38120124	3	2	18	1	0	0	0	0	1	0	0	0	17696	1029	36	4	665	4	ZFAND3	6	38120124	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	3170606	38120124	132994943	64	4100											
KLHDC3	116138	broad.mit.edu	37	chr6	42985674	42985674	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcctgtgtcctaggcaagAtcatgtacatttttgggggc	8	12	12	9	0	1	1	1	0	0	1	2	1	2	1	2	3	2	2	2	3	3	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr6:42985674A>C	uc003otl.2	+	4	584	c.415A>C	c.(415-417)ATC>CTC	p.I139L	KLHDC3_uc003otm.2_RNA|KLHDC3_uc010jyf.2_Missense_Mutation_p.I139L|KLHDC3_uc003otn.2_Intron|KLHDC3_uc003oto.2_Missense_Mutation_p.I80L	NM_057161	NP_476502	Q9BQ90	KLDC3_HUMAN	kelch domain containing 3	139	Kelch 3.				reciprocal meiotic recombination	cytoplasm|nuclear chromatin	chromatin binding|protein binding			upper_aerodigestive_tract(1)	1			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCTAGGCAAGATCATGTACAT	0.512													27	77					0	0	0	0	C	42985674	C	C	42985674	3	2	18	1	0	0	0	0	1	0	0	0	8396	333	12	5	425	5	KLHDC3	6	42985674	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	4865550	42985674	128129393	65	4101											
GSTA4	2941	broad.mit.edu	37	chr6	52847396	52847396	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggaaaggaaatgcagacagGatattaggaattttctcttc	15	11	10	5	0	1	1	0	0	1	1	3	5	1	5	0	4	1	1	0	4	5	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr6:52847396G>A	uc003pbc.2	-	5	586	c.522C>T	c.(520-522)ATC>ATT	p.I174I	GSTA4_uc003pbd.2_Silent_p.I81I|GSTA4_uc003pbe.2_Silent_p.I81I|GSTA4_uc003pbf.2_Silent_p.I174I	NM_001512	NP_001503	O15217	GSTA4_HUMAN	glutathione S-transferase alpha 4	174	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity|protein homodimerization activity				0	Lung NSC(77;0.103)				Glutathione(DB00143)	ATGCAGACAGGATATTAGGAA	0.408													19	39					0	0	0	0	A	52847396	A	A	52847396	2	1	18	1	0	0	0	0	0	0	0	1	6872	1164	41	2		2	GSTA4	6	52847396	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	9861722	52847396	118267671	66	4102											
FHL5	9457	broad.mit.edu	37	chr6	97063544	97063544	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtggcatagcgaatgctttAactgcgggaaatgctctgtc	10	11	12	8	2	1	0	0	0	1	0	2	2	1	1	0	2	5	3	0	2	4	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr6:97063544A>G	uc003pos.1	+	7	1156	c.751A>G	c.(751-753)AAC>GAC	p.N251D	FHL5_uc003pot.1_Missense_Mutation_p.N251D	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	251	LIM zinc-binding 4.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		CGAATGCTTTAACTGCGGGAA	0.428													8	53					0	0	0	0	G	97063544	G	G	97063544	3	3	18	1	0	0	0	0	1	0	0	0	5913	362	13	5	769	5	FHL5	6	97063544	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	44216148	97063544	74051523	67	4103											
GRIK2	2898	broad.mit.edu	37	chr6	102503442	102503442	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atacaaatccaaaaaaaacgCtcaattggaaaaggtaaatg	22	7	6	6	1	1	0	1	0	0	0	2	1	2	1	1	2	2	2	1	2	11	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr6:102503442C>A	uc003pqp.3	+	15	2798	c.2549C>A	c.(2548-2550)GCT>GAT	p.A850D	GRIK2_uc003pqo.3_Missense_Mutation_p.A850D|GRIK2_uc010kcw.2_Missense_Mutation_p.A850D	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	850	Cytoplasmic (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	AAAAAAAACGCTCAATTGGAA	0.328													20	100					9.95505e-16	1.13427e-15	1	0	A	102503442	A	A	102503442	3	1	18	1	0	0	0	0	1	0	0	0	6813	797	28	4	2607	4	GRIK2	6	102503442	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	5439898	102503442	68611625	68	4104											
NCOA7	135112	broad.mit.edu	37	chr6	126210254	126210258	+	Frame_Shift_Del	DEL	GAGAA	-	-																															ccagaccaatagtacctttgGagaagtccacaggacataca																										TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr6:126210254_126210258delGAGAA	uc010kes.2	+	11	1503_1507	c.1054_1058delGAGAA	c.(1054-1059)GAGAAGfs	p.E352fs	NCOA7_uc003qae.3_Frame_Shift_Del_p.E352fs|NCOA7_uc003qah.2_Frame_Shift_Del_p.E341fs|NCOA7_uc003qai.2_Frame_Shift_Del_p.E352fs|NCOA7_uc010ket.2_Frame_Shift_Del_p.E237fs	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	352_353					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		AGTACCTTTGGAGAAGTCCACAGGA	0.434													---	---	---								-	126210258	-	-	126210254	7	5	18	1	0	1	0	1	0	0	0	0	10288	1175	41	0	1084	0	NCOA7	6	126210254	Frame_Shift_Del	DEL	GAGAA	TCGA-BA-6871-01A-11D-1870-08	23706812	126210254	44904813	69	4105											
HECA	51696	broad.mit.edu	37	chr6	139495643	139495643	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctgggcactatgtacacCtacgacatcctggctgcctc	8	9	9	15	1	0	0	0	0	0	0	2	1	1	0	3	2	4	4	3	2	3	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr6:139495643C>T	uc003qin.2	+	3	1719	c.1434C>T	c.(1432-1434)ACC>ACT	p.T478T		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	478					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		CTATGTACACCTACGACATCC	0.547													12	131					0	0	0	0	T	139495643	T	T	139495643	2	4	18	1	0	0	0	0	0	0	0	1	7077	668	24	4		4	HECA	6	139495643	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08	13285389	139495643	31619424	70	4106											
SUN1	23353	broad.mit.edu	37	chr7	912967	912967	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatggcgaacctgtcaagtGaagacactactcattatttt	12	13	7	9	1	3	2	3	1	0	1	3	3	3	2	1	1	2	0	1	1	5	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:912967G>A	uc011jvp.1	+	20	2436	c.2357G>A	c.(2356-2358)TGA>TAA	p.*786*	GET4_uc003sjj.1_Intron|SUN1_uc003sjf.2_Silent_p.*703*|SUN1_uc011jvq.1_Silent_p.*683*|SUN1_uc003sjg.2_Silent_p.*691*|SUN1_uc011jvr.1_Silent_p.*584*|SUN1_uc003sji.2_Silent_p.*624*|SUN1_uc003sjk.2_Silent_p.*425*	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	786	Perinuclear space.|SUN.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						CCTGTCAAGTGAAGACACTAC	0.423											OREG0017816	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	67					0	0	0	0	A	912967	A	A	912967	2	1	18	1	0	0	0	0	0	0	0	1	15457	1285	45	2		2	SUN1	7	912967	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08		912967	158225696	71	4107											
CARD11	84433	broad.mit.edu	37	chr7	2987368	2987368	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccacattctcccacaaggCgtcctcttcatccttcagcg	7	11	5	18	2	4	0	2	0	2	0	8	0	7	0	4	1	1	0	4	1	1	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:2987368C>T	uc003smv.2	-	3	465	c.61G>A	c.(61-63)GCC>ACC	p.A21T		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	21	CARD.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCCCACAAGGCGTCCTCTTCA	0.498			Mis		DLBCL								27	99					0	0	0	0	T	2987368	T	T	2987368	3	4	18	1	0	0	0	0	1	0	0	0	2657	768	27	1	3495	1	CARD11	7	2987368	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	2074401	2987368	156151295	72	4108											
PMS2	5395	broad.mit.edu	37	chr7	6043690	6043690	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atagtccttaagctttagatCtagaaagtttaaaatattta	16	16	5	4	0	1	2	0	0	1	2	2	2	2	2	1	0	1	2	1	0	9	10			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:6043690C>G	uc003spl.2	-	3	251	c.164_splice	c.e3-1	p.D55_splice	PMS2_uc003spj.2_Splice_Site|PMS2_uc003spk.2_Splice_Site|PMS2_uc011jwl.1_Splice_Site|PMS2_uc010ktg.2_Splice_Site|PMS2_uc010kte.2_Splice_Site_p.D55_splice|PMS2_uc010ktf.1_Splice_Site_p.D55_splice	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform						mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		AGCTTTAGATCTAGAAAGttt	0.289			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				33	78					0	0	0	0	G	6043690	G	G	6043690	5	3	18	1	0	0	0	0	0	0	1	0	12198	927	32	2	2477	2	PMS2	7	6043690	Splice_Site	SNP	C	TCGA-BA-6871-01A-11D-1870-08	3056322	6043690	153094973	73	4109											
ZNF12	7559	broad.mit.edu	37	chr7	6731676	6731676	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaggatttcccacactgattAcattcgtaaggtttctctcc	10	14	6	11	1	1	1	0	1	1	0	5	2	3	2	2	2	1	2	2	2	3	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:6731676A>T	uc003sqt.1	-	5	1451	c.897T>A	c.(895-897)TGT>TGA	p.C299*	ZNF12_uc011jxa.1_Nonsense_Mutation_p.C137*|ZNF12_uc003sqs.1_Nonsense_Mutation_p.C261*	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	299	C2H2-type 2.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		CACACTGATTACATTCGTAAG	0.423													70	51					0	0	0	0	T	6731676	T	T	6731676	4	4	18	1	0	0	0	0	0	1	0	0	17785	389	14	5	1200	5	ZNF12	7	6731676	Nonsense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	687986	6731676	152406987	74	4110											
WIPF3	644150	broad.mit.edu	37	chr7	29923502	29923502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggccctggctcccgcgcgcCctctcccaggcttcccaaca	4	6	10	21	3	1	0	0	0	1	0	4	0	3	0	5	3	1	2	5	3	1	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:29923502C>T	uc003taj.1	+	4	392	c.392C>T	c.(391-393)CCC>CTC	p.P131L		NM_001080529	NP_001073998	A6NGB9	WIPF3_HUMAN	WAS/WASL interacting protein family, member 3	131										ovary(1)	1						TCCCGCGCGCCCTCTCCCAGG	0.627													6	18					0	0	0	0	T	29923502	T	T	29923502	3	4	18	1	0	0	0	0	1	0	0	0	17437	623	22	4	406	4	WIPF3	7	29923502	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	23191826	29923502	129215161	75	4111											
DDX56	54606	broad.mit.edu	37	chr7	44610375	44610375	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttgtcccctttgggccctCggccccgacgcttgcccttg	2	11	10	18	3	0	0	0	0	0	0	2	1	1	0	6	2	1	1	6	2	0	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:44610375C>T	uc003tlg.2	-	7	1635	c.992G>A	c.(991-993)CGA>CAA	p.R331Q	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Missense_Mutation_p.R267Q|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Intron|DDX56_uc010kyh.1_RNA	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	331	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1						TTTGGGCCCTCGGCCCCGACG	0.527													32	75					0	0	0	0	T	44610375	T	T	44610375	3	4	18	1	0	0	0	0	1	0	0	0	4391	884	31	1	683	1	DDX56	7	44610375	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	14686873	44610375	114528288	76	4112											
PKD1L1	168507	broad.mit.edu	37	chr7	47924243	47924243	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcttgaatgtcactgtaaTaggcttcaaaatctataaga	14	14	6	7	0	4	2	2	1	2	1	4	2	4	2	0	1	0	2	0	1	7	7			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:47924243T>C	uc003tny.1	-	19	3218	c.3218A>G	c.(3217-3219)TAT>TGT	p.Y1073C		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1073	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GTCACTGTAATAGGCTTCAAA	0.448													9	29					0	0	0	0	C	47924243	C	C	47924243	3	2	18	1	0	0	0	0	1	0	0	0	12019	1406	49	5	5487	5	PKD1L1	7	47924243	Missense_Mutation	SNP	T	TCGA-BA-6871-01A-11D-1870-08	3313868	47924243	111214420	77	4113											
IKZF1	10320	broad.mit.edu	37	chr7	50358680	50358680	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgctgatgagggtcaagAcatgtcccaagtttcaggtg	10	10	14	7	0	2	3	2	2	0	1	3	4	3	4	1	3	1	2	1	3	2	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:50358680A>G	uc003tow.3	+	3	191	c.23A>G	c.(22-24)GAC>GGC	p.D8G	IKZF1_uc003tox.3_Missense_Mutation_p.D8G|IKZF1_uc003toy.3_Missense_Mutation_p.D8G|IKZF1_uc011kck.1_Missense_Mutation_p.D8G|IKZF1_uc003tov.1_Missense_Mutation_p.D8G	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	8					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(24)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GAGGGTCAAGACATGTCCCAA	0.438			D		ALL								45	138					0	0	0	0	G	50358680	G	G	50358680	3	3	18	1	0	0	0	0	1	0	0	0	7653	275	10	5	25	5	IKZF1	7	50358680	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	2434437	50358680	108779983	78	4114											
IKZF1	10320	broad.mit.edu	37	chr7	50450284	50450284	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcggggcctcattcacccaGaagggcaacctgctccggca	8	6	12	15	2	2	1	2	0	0	1	3	1	3	1	4	4	3	3	4	4	2	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:50450284G>A	uc003tow.3	+	6	636	c.468G>A	c.(466-468)CAG>CAA	p.Q156Q	IKZF1_uc003tox.3_Silent_p.Q156Q|IKZF1_uc003toy.3_Silent_p.Q156Q|IKZF1_uc011kck.1_Silent_p.Q69Q|IKZF1_uc003toz.3_Silent_p.Q126Q|IKZF1_uc010kyx.2_Intron	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	156	Required for both high-affinity DNA binding and pericentromeric heterochromatin localization (By similarity).|C2H2-type 2.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(74)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CATTCACCCAGAAGGGCAACC	0.612			D		ALL								7	21					0	0	0	0	A	50450284	A	A	50450284	2	1	18	1	0	0	0	0	0	0	0	1	7653	933	33	2		2	IKZF1	7	50450284	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	91604	50450284	108688379	79	4115											
POM121	9883	broad.mit.edu	37	chr7	72413639	72413639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttggcggtgccacgcactCggcgtttgggttgaaagcca	6	10	14	11	4	0	1	0	1	0	0	1	1	0	1	2	4	2	3	2	4	1	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:72413639C>T	uc003twk.2	+	11	3107	c.3107C>T	c.(3106-3108)TCG>TTG	p.S1036L	POM121_uc003twj.2_Missense_Mutation_p.S771L|POM121_uc010lam.1_Missense_Mutation_p.S771L	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1036	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				GCCACGCACTCGGCGTTTGGG	0.652													10	63					0	0	0	0	T	72413639	T	T	72413639	3	4	18	1	0	0	0	0	1	0	0	0	12294	893	31	1	2350	1	POM121	7	72413639	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	21963355	72413639	86725024	80	4116											
HIP1	3092	broad.mit.edu	37	chr7	75168691	75168691	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagctcgtagtgctttttccGaagctctcccagtttttgac	7	15	8	11	2	1	1	0	1	1	0	4	2	2	1	2	0	3	5	2	0	3	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:75168691G>A	uc003uds.1	-	30	3054	c.3013C>T	c.(3013-3015)CGG>TGG	p.R1005W	HIP1_uc011kfz.1_Missense_Mutation_p.R831W	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	1005	I/LWEQ.			R->E: Reduces AR-induced nuclear translocation.	activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						TGCTTTTTCCGAAGCTCTCCC	0.502			T	PDGFRB	CMML								85	293					0	0	0	0	A	75168691	A	A	75168691	3	1	18	1	0	0	0	0	1	0	0	0	7153	1057	37	1	108	1	HIP1	7	75168691	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	2755052	75168691	83969972	81	4117											
PCLO	27445	broad.mit.edu	37	chr7	82585126	82585126	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcagactcgaagatccctCtccccttgacctatcttcag	9	11	6	15	1	3	3	1	1	2	2	6	4	4	3	4	0	1	1	4	0	2	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:82585126C>G	uc003uhx.2	-	5	5432	c.5143G>C	c.(5143-5145)GAG>CAG	p.E1715Q	PCLO_uc003uhv.2_Missense_Mutation_p.E1715Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1646					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GAAGATCCCTCTCCCCTTGAC	0.463													21	48					0	0	0	0	G	82585126	G	G	82585126	3	3	18	1	0	0	0	0	1	0	0	0	11637	922	32	2	10386	2	PCLO	7	82585126	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	7416435	82585126	76553537	82	4118											
STEAP4	79689	broad.mit.edu	37	chr7	87908865	87908865	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagataccatctgagatttgAagggctgaggaatctcttcc	12	11	10	8	0	2	4	0	3	2	2	4	6	3	5	2	2	1	1	2	2	4	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:87908865A>T	uc003ujs.2	-	5	1333	c.1228T>A	c.(1228-1230)TCA>ACA	p.S410T	STEAP4_uc010lek.2_Missense_Mutation_p.S234T	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	410					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					CTGAGATTTGAAGGGCTGAGG	0.448													22	32					0	0	0	0	T	87908865	T	T	87908865	3	4	18	1	0	0	0	0	1	0	0	0	15346	246	9	5	155	5	STEAP4	7	87908865	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	5323739	87908865	71229798	83	4119											
AKAP9	10142	broad.mit.edu	37	chr7	91695764	91695764	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagccattgacagagaacaTgagagagatgtattccaaca	17	7	9	8	0	0	4	0	2	0	3	1	7	1	4	2	0	3	1	2	0	4	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:91695764T>C	uc003ulg.2	+	26	6459	c.6234T>C	c.(6232-6234)CAT>CAC	p.H2078H	AKAP9_uc003ulf.2_Silent_p.H2078H|AKAP9_uc003uli.2_Silent_p.H1701H	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2090	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACAGAGAACATGAGAGAGATG	0.358			T	BRAF	papillary thyroid								15	58					0	0	0	0	C	91695764	C	C	91695764	2	2	18	1	0	0	0	0	0	0	0	1	459	1461	51	5		5	AKAP9	7	91695764	Silent	SNP	T	TCGA-BA-6871-01A-11D-1870-08	3786899	91695764	67442899	84	4120											
LRRN3	54674	broad.mit.edu	37	chr7	110763135	110763135	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctggatttatctcaaaacAatttatcttcagtcaccaat	13	14	4	10	0	4	0	3	0	2	0	5	1	4	1	2	1	1	0	2	1	6	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:110763135A>T	uc003vft.3	+	4	1353	c.307A>T	c.(307-309)AAT>TAT	p.N103Y	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.N103Y|LRRN3_uc003vfs.3_Missense_Mutation_p.N103Y	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	103	Extracellular (Potential).|LRR 2.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ATCTCAAAACAATTTATCTTC	0.353													5	35					0	0	0	0	T	110763135	T	T	110763135	3	4	18	1	0	0	0	0	1	0	0	0	9086	130	5	5	309	5	LRRN3	7	110763135	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	19067371	110763135	48375528	85	4121											
MGAM	8972	broad.mit.edu	37	chr7	141797392	141797392	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgtttatgtttcattttaGaatgccagaaatgtcactgc	10	17	7	7	0	2	2	2	0	0	2	2	2	2	2	1	0	2	2	1	0	4	6			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr7:141797392G>C	uc003vwy.2	+	43	5059	c.5005_splice	c.e43-1	p.N1669_splice		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase						polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTTCATTTTAGAATGCCAGAA	0.353													16	36					0	0	0	0	C	141797392	C	C	141797392	5	2	18	1	0	0	0	0	0	0	1	0	9594	956	33	2	5170	2	MGAM	7	141797392	Splice_Site	SNP	G	TCGA-BA-6871-01A-11D-1870-08	31034257	141797392	17341271	86	4122											
CSMD3	114788	broad.mit.edu	37	chr8	114110999	114110999	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttaccatatggtaggtggCtcagaaccttctatttctaa	11	14	7	9	0	3	1	1	0	2	1	3	1	3	1	2	3	2	2	2	3	6	7			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr8:114110999C>A	uc003ynu.2	-	5	1062	c.903G>T	c.(901-903)GAG>GAT	p.E301D	CSMD3_uc003ynt.2_Missense_Mutation_p.E261D|CSMD3_uc011lhx.1_Missense_Mutation_p.E301D|CSMD3_uc010mcx.1_Missense_Mutation_p.E301D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	301	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGGTAGGTGGCTCAGAACCTT	0.363										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	60					0.00909568	0.00944745	1	0	A	114110999	A	A	114110999	3	1	18	1	0	0	0	0	1	0	0	0	3963	796	28	4	10488	4	CSMD3	8	114110999	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08		114110999	32253023	87	4123											
OC90	729330	broad.mit.edu	37	chr8	133048660	133048660	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgtcagcctcagtctctgCagccactgtgaacagaaatc	10	10	8	13	0	4	2	2	1	2	1	6	2	4	2	2	0	4	1	2	0	2	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr8:133048660C>A	uc003ytg.2	-	8	637	c.637G>T	c.(637-639)GCA>TCA	p.A213S	OC90_uc011lix.1_Intron	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	229					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TCAGTCTCTGCAGCCACTGTG	0.463													16	100					0.000566183	0.000604787	1	0	A	133048660	A	A	133048660	3	1	18	1	0	0	0	0	1	0	0	0	10868	725	25	4		4	OC90	8	133048660	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	18937661	133048660	13315362	88	4124											
KCNQ3	3786	broad.mit.edu	37	chr8	133153390	133153390	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cattaccttcagaactctgcCagaaagcgtaggctttcatg	11	11	8	11	1	3	2	2	0	1	2	3	2	3	2	2	1	4	2	2	1	4	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr8:133153390C>A	uc003ytj.2	-	10	1676	c.1451G>T	c.(1450-1452)TGG>TTG	p.W484L	KCNQ3_uc010mdt.2_Missense_Mutation_p.W484L	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	484					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			AGAACTCTGCCAGAAAGCGTA	0.493													36	81					1.69901e-12	1.92418e-12	1	0	A	133153390	A	A	133153390	3	1	18	1	0	0	0	0	1	0	0	0	8123	595	21	4	1191	4	KCNQ3	8	133153390	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	104730	133153390	13210632	89	4125											
TRAPPC9	83696	broad.mit.edu	37	chr8	140744287	140744287	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcaggtcgtagttgtgcaCgccgttctggtggtcctgga	4	12	16	9	3	1	0	0	0	1	0	3	1	2	1	2	4	2	5	2	4	1	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr8:140744287C>T	uc003yvj.2	-	22	3348	c.3214G>A	c.(3214-3216)GTG>ATG	p.V1072M	TRAPPC9_uc003yvh.2_Missense_Mutation_p.V1170M	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	1072					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						TAGTTGTGCACGCCGTTCTGG	0.682													3	16					0	0	0	0	T	140744287	T	T	140744287	3	4	18	1	0	0	0	0	1	0	0	0	16532	536	19	1	240	1	TRAPPC9	8	140744287	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	7590897	140744287	5619735	90	4126											
TOP1MT	116447	broad.mit.edu	37	chr8	144406249	144406249	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcagcccggtactgggagcGgatctcgtccacaaatcccc	8	7	11	15	3	2	0	1	0	1	0	5	2	4	2	4	3	3	1	4	3	2	1	rs144092447		TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr8:144406249G>A	uc003yxz.2	-	7	899	c.880C>T	c.(880-882)CGC>TGC	p.R294C	TOP1MT_uc011lkd.1_Missense_Mutation_p.R196C|TOP1MT_uc011lke.1_Missense_Mutation_p.R196C|TOP1MT_uc010mfb.2_Missense_Mutation_p.R196C|TOP1MT_uc011lkf.1_Missense_Mutation_p.R89C|TOP1MT_uc010mfd.1_Missense_Mutation_p.R89C	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	294					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	TACTGGGAGCGGATCTCGTCC	0.527													4	206					0	0	0	0	A	144406249	A	A	144406249	3	1	18	1	0	0	0	0	1	0	0	0	16431	1116	39	1	957	1	TOP1MT	8	144406249	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	3661962	144406249	1957773	91	4127											
EPPK1	83481	broad.mit.edu	37	chr8	144947143	144947143	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcagggccttggacacaggGagcagctggccccgggcgag	7	4	18	12	2	0	0	0	0	0	0	0	3	0	2	3	5	3	3	3	5	0	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr8:144947143G>A	uc003zaa.1	-	1	292	c.279C>T	c.(277-279)CTC>CTT	p.L93L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	93	Plectin 2.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGACACAGGGAGCAGCTGGC	0.701													5	24					0	0	0	0	A	144947143	A	A	144947143	2	1	18	1	0	0	0	0	0	0	0	1	5214	1161	41	2		2	EPPK1	8	144947143	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	540894	144947143	1416879	92	4128											
PTPRD	5789	broad.mit.edu	37	chr9	8525016	8525016	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttggtcagactcttcactCtgctcaatctgaagggctcc	7	12	8	14	0	6	2	3	1	3	1	7	2	7	2	2	2	1	2	2	2	2	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr9:8525016C>G	uc003zkk.2	-	17	1299	c.588G>C	c.(586-588)CAG>CAC	p.Q196H	PTPRD_uc003zkp.2_Missense_Mutation_p.Q196H|PTPRD_uc003zkq.2_Missense_Mutation_p.Q196H|PTPRD_uc003zkr.2_Missense_Mutation_p.Q190H|PTPRD_uc003zks.2_Missense_Mutation_p.Q190H|PTPRD_uc003zkl.2_Missense_Mutation_p.Q196H|PTPRD_uc003zkm.2_Missense_Mutation_p.Q187H|PTPRD_uc003zkn.2_Missense_Mutation_p.Q196H|PTPRD_uc003zko.2_Missense_Mutation_p.Q193H	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	196	Extracellular (Potential).|Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ACTCTTCACTCTGCTCAATCT	0.338										TSP Lung(15;0.13)			41	115					0	0	0	0	G	8525016	G	G	8525016	3	3	18	1	0	0	0	0	1	0	0	0	12864	912	32	2	5334	2	PTPRD	9	8525016	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08		8525016	132688415	93	4129											
PSIP1	11168	broad.mit.edu	37	chr9	15472711	15472711	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcctttcagcatattccttCtgtgagcagtctgaaagttc	8	14	9	10	0	3	2	1	2	2	0	5	2	4	2	2	1	2	3	2	1	2	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr9:15472711C>G	uc003zlv.3	-	10	1226	c.896G>C	c.(895-897)AGA>ACA	p.R299T	PSIP1_uc003zlw.3_Missense_Mutation_p.R299T|PSIP1_uc003zlz.3_Missense_Mutation_p.R299T|PSIP1_uc003zma.3_Missense_Mutation_p.R290T|PSIP1_uc003zly.2_Missense_Mutation_p.R299T	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	299					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		CATATTCCTTCTGTGAGCAGT	0.373													37	51					0	0	0	0	G	15472711	G	G	15472711	3	3	18	1	0	0	0	0	1	0	0	0	12725	913	32	2	753	2	PSIP1	9	15472711	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	6947695	15472711	125740720	94	4130											
NOL8	55035	broad.mit.edu	37	chr9	95062242	95062242	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaactgctgtcttgtaaacGagggtcttcctgccagacaa	10	11	10	10	1	2	2	0	1	2	1	3	3	3	2	2	1	4	2	2	1	4	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr9:95062242G>A	uc004arv.2	-	14	3569	c.3232C>T	c.(3232-3234)CGT>TGT	p.R1078C	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Missense_Mutation_p.R310C|NOL8_uc011ltw.1_Missense_Mutation_p.R1010C	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	1078					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						TCTTGTAAACGAGGGTCTTCC	0.413													74	131					0	0	0	0	A	95062242	A	A	95062242	3	1	18	1	0	0	0	0	1	0	0	0	10581	1058	37	1	287	1	NOL8	9	95062242	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	79589531	95062242	46151189	95	4131											
GRIN3A	116443	broad.mit.edu	37	chr9	104375732	104375732	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggagcatatccataaaccCatgtgacttgtattgactga	13	12	8	8	0	0	3	0	3	0	0	1	4	1	4	2	1	2	2	2	1	4	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr9:104375732C>A	uc004bbp.1	-	6	3293	c.2692G>T	c.(2692-2694)GGG>TGG	p.G898W	GRIN3A_uc004bbq.1_Missense_Mutation_p.G898W	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	898	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TCCATAAACCCATGTGACTTG	0.463													22	8					2.27525e-19	2.65682e-19	1	0	A	104375732	A	A	104375732	3	1	18	1	0	0	0	0	1	0	0	0	6822	594	21	4	671	4	GRIN3A	9	104375732	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	9313490	104375732	36837699	96	4132											
GRIN3A	116443	broad.mit.edu	37	chr9	104432608	104432608	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaaatggactcttccattCatacagagtgaggaagacgg	14	8	10	9	1	2	3	1	1	1	2	3	5	3	5	2	3	1	0	2	3	3	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr9:104432608C>T	uc004bbp.1	-	3	2687	c.2086G>A	c.(2086-2088)GAA>AAA	p.E696K	GRIN3A_uc004bbq.1_Missense_Mutation_p.E696K	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	696	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CTCTTCCATTCATACAGAGTG	0.488													29	77					0	0	0	0	T	104432608	T	T	104432608	3	4	18	1	0	0	0	0	1	0	0	0	6822	835	29	2	1289	2	GRIN3A	9	104432608	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	56876	104432608	36780823	97	4133											
C9orf50	375759	broad.mit.edu	37	chr9	132375462	132375462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcagcggccttcttccatGaacagaagggcaggctgctg	9	7	14	11	1	1	2	0	1	1	1	2	3	2	2	2	3	4	4	2	3	2	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr9:132375462G>A	uc004byc.3	-	6	1314	c.1112C>T	c.(1111-1113)TCA>TTA	p.S371L	C9orf50_uc004byb.3_RNA	NM_199350	NP_955382	Q5SZB4	CI050_HUMAN	hypothetical protein LOC375759	371										ovary(1)|central_nervous_system(1)	2		Ovarian(14;0.00556)				CTTCTTCCATGAACAGAAGGG	0.607													11	33					0	0	0	0	A	132375462	A	A	132375462	3	1	18	1	0	0	0	0	1	0	0	0	2499	1294	45	2	191	2	C9orf50	9	132375462	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	27942854	132375462	8837969	98	4134											
COL5A1	1289	broad.mit.edu	37	chr9	137715309	137715309	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccacccaggacccccaggCcccccggtaagtagcccttg	7	4	11	19	1	0	0	0	0	0	0	0	1	0	1	8	4	1	2	8	4	2	3	rs61735501	byFrequency	TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr9:137715309C>A	uc004cfe.2	+	61	5074	c.4692C>A	c.(4690-4692)GGC>GGA	p.G1564G	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1564	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GACCCCCAGGCCCCCCGGTAA	0.597													26	50					1.74197e-06	1.89301e-06	1	0	A	137715309	A	A	137715309	2	1	18	1	0	0	0	0	0	0	0	1	3711	726	26	4		4	COL5A1	9	137715309	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08	5339847	137715309	3498122	99	4135											
GLT6D1	360203	broad.mit.edu	37	chr9	138531020	138531020	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataaaaccaataacagcattCttttagaattcattctctcc	15	14	2	10	0	3	1	1	0	2	1	5	1	4	1	2	0	3	1	2	0	6	7			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr9:138531020C>G	uc010nbd.1	-	2	268	c.14G>C	c.(13-15)AGA>ACA	p.R5T		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	5	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		TAACAGCATTCTTTTAGAATT	0.289													13	32					0	0	0	0	G	138531020	G	G	138531020	3	3	18	1	0	0	0	0	1	0	0	0	6505	913	32	2	832	2	GLT6D1	9	138531020	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	815711	138531020	2682411	100	4136											
UPF2	26019	broad.mit.edu	37	chr10	11994141	11994141	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaattacagagtttgatCtttggtcttagcagttctag	11	15	10	5	0	3	3	0	1	3	2	3	4	3	3	0	1	2	3	0	1	4	6			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr10:11994141C>A	uc001ila.2	-	14	3432	c.2958G>T	c.(2956-2958)AAG>AAT	p.K986N	UPF2_uc001ilb.2_Missense_Mutation_p.K986N|UPF2_uc001ilc.2_Missense_Mutation_p.K986N|UPF2_uc009xiz.1_Missense_Mutation_p.K986N	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	986	MIF4G 3.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				AGAGTTTGATCTTTGGTCTTA	0.368													87	82					8.84886e-50	1.0529e-49	1	0	A	11994141	A	A	11994141	3	1	18	1	0	0	0	0	1	0	0	0	17072	912	32	2	892	2	UPF2	10	11994141	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08		11994141	123540606	101	4137											
UPF2	26019	broad.mit.edu	37	chr10	11994167	11994167	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttagcagttctagtgtatCactgatcatgtaatctatat	11	17	6	7	0	5	1	2	1	3	0	5	1	5	1	0	0	1	4	0	0	6	7			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr10:11994167C>T	uc001ila.2	-	14	3406	c.2932G>A	c.(2932-2934)GAT>AAT	p.D978N	UPF2_uc001ilb.2_Missense_Mutation_p.D978N|UPF2_uc001ilc.2_Missense_Mutation_p.D978N|UPF2_uc009xiz.1_Missense_Mutation_p.D978N	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	978	MIF4G 3.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				TCTAGTGTATCACTGATCATG	0.353													76	66					0	0	0	0	T	11994167	T	T	11994167	3	4	18	1	0	0	0	0	1	0	0	0	17072	826	29	2	918	2	UPF2	10	11994167	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	26	11994167	123540580	102	4138											
CUBN	8029	broad.mit.edu	37	chr10	17113568	17113568	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttaggaaaaaaaggcgagcGaatgaccccttctccagtta	14	8	10	9	2	1	1	0	1	1	0	2	4	1	2	3	2	1	2	3	2	6	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr10:17113568G>A	uc001ioo.2	-	19	2534	c.2482C>T	c.(2482-2484)CGC>TGC	p.R828C		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	828	CUB 4.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAAGGCGAGCGAATGACCCCT	0.413													17	66					0	0	0	0	A	17113568	A	A	17113568	3	1	18	1	0	0	0	0	1	0	0	0	4068	1058	37	1	8585	1	CUBN	10	17113568	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	5119401	17113568	118421179	103	4139											
NRP1	8829	broad.mit.edu	37	chr10	33619748	33619748	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcacttgggtgataagaatGaggataaccaggagatgtaa	15	10	12	4	0	1	4	1	2	0	2	1	6	1	5	1	3	1	1	1	3	4	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr10:33619748G>A	uc001iwx.3	-	2	659	c.136C>T	c.(136-138)CAT>TAT	p.H46Y	NRP1_uc001iwv.3_Missense_Mutation_p.H46Y|NRP1_uc009xlz.2_Missense_Mutation_p.H46Y|NRP1_uc001iww.3_5'UTR|NRP1_uc001iwy.3_Missense_Mutation_p.H46Y|NRP1_uc001iwz.2_Missense_Mutation_p.H46Y|NRP1_uc001ixa.2_Missense_Mutation_p.H46Y|NRP1_uc001ixb.1_Missense_Mutation_p.H46Y|NRP1_uc001ixc.1_Missense_Mutation_p.H46Y	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	46	CUB 1.|Extracellular (Potential).				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	TGATAAGAATGAGGATAACCA	0.418													24	30					0	0	0	0	A	33619748	A	A	33619748	3	1	18	1	0	0	0	0	1	0	0	0	10714	1290	45	2	2710	2	NRP1	10	33619748	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	16506180	33619748	101914999	104	4140											
ANKRD30A	91074	broad.mit.edu	37	chr10	37451602	37451602	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccggggaagccatctgccttCgaggtatttagttttatgat	8	14	11	8	2	1	1	0	1	1	0	2	3	1	2	3	3	2	2	3	3	4	6			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr10:37451602C>G	uc001iza.1	+	16	1857	c.1758C>G	c.(1756-1758)TTC>TTG	p.F586L		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	642						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CATCTGCCTTCGAGGTATTTA	0.328													47	65					0	0	0	0	G	37451602	G	G	37451602	3	3	18	1	0	0	0	0	1	0	0	0	658	883	31	3	1820	3	ANKRD30A	10	37451602	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	3831854	37451602	98083145	105	4141											
BICC1	80114	broad.mit.edu	37	chr10	60559980	60559980	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatataaaatatggtgcaatAtccacttcatcacttggaga	15	12	7	7	0	2	1	2	0	0	1	3	3	3	1	1	2	1	1	1	2	6	6			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr10:60559980A>G	uc001jki.1	+	13	1752	c.1752A>G	c.(1750-1752)ATA>ATG	p.I584M	BICC1_uc001jkj.1_Missense_Mutation_p.I225M	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	584					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						ATGGTGCAATATCCACTTCAT	0.333													15	7					0	0	0	0	G	60559980	G	G	60559980	3	3	18	1	0	0	0	0	1	0	0	0	1430	439	16	5	1802	5	BICC1	10	60559980	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	23108378	60559980	74974767	106	4142											
PIK3AP1	118788	broad.mit.edu	37	chr10	98469731	98469731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgatgaggatgtcgcatcctCtgggcacccctggacaagaa	10	7	12	12	2	1	2	0	1	1	1	3	5	2	4	3	3	0	2	3	3	2	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr10:98469731C>T	uc001kmq.2	-	2	151	c.23G>A	c.(22-24)AGA>AAA	p.R8K		NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	8						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		GTCGCATCCTCTGGGCACCCC	0.592													13	51					0	0	0	0	T	98469731	T	T	98469731	3	4	18	1	0	0	0	0	1	0	0	0	11963	913	32	2	2458	2	PIK3AP1	10	98469731	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	37909751	98469731	37065016	107	4143											
TECTB	6975	broad.mit.edu	37	chr10	114044408	114044408	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgttacaatggggtccaCgaaggaggttactaccaatt	11	11	11	8	1	0	0	0	0	0	0	1	2	1	1	2	4	3	2	2	4	6	4	rs146576556		TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr10:114044408C>T	uc001kzr.1	+	2	192	c.192C>T	c.(190-192)CAC>CAT	p.H64H		NM_058222	NP_478129	Q96PL2	TECTB_HUMAN	tectorin beta precursor	64	ZP.					anchored to membrane|plasma membrane|proteinaceous extracellular matrix					0		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		ATGGGGTCCACGAAGGAGGTT	0.488													25	14					0	0	0	0	T	114044408	T	T	114044408	2	4	18	1	0	0	0	0	0	0	0	1	15814	535	19	1		1	TECTB	10	114044408	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08	15574677	114044408	21490339	108	4144											
PSTK	118672	broad.mit.edu	37	chr10	124742535	124742535	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaagtctaccagctggctcGgaaatgtaattaaaactttt	13	13	8	7	1	1	1	0	1	1	0	2	2	1	2	1	2	3	3	1	2	6	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr10:124742535G>A	uc001lgy.1	+	2	943	c.503G>A	c.(502-504)CGG>CAG	p.R168Q		NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase	168							ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		CAGCTGGCTCGGAAATGTAAT	0.313													58	61					0	0	0	0	A	124742535	A	A	124742535	3	1	18	1	0	0	0	0	1	0	0	0	12782	1116	39	1	509	1	PSTK	10	124742535	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	10698127	124742535	10792212	109	4145											
GPR26	2849	broad.mit.edu	37	chr10	125426287	125426287	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggccaagatgcgcctccgcGacgcggcgctcatggtggcc	5	5	16	15	6	1	1	1	0	0	1	2	2	2	1	4	4	1	1	4	4	1	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr10:125426287G>A	uc001lhh.2	+	1	417	c.364G>A	c.(364-366)GAC>AAC	p.D122N		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	122	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				GCGCCTCCGCGACGCGGCGCT	0.701													3	6					0	0	0	0	A	125426287	A	A	125426287	3	1	18	1	0	0	0	0	1	0	0	0	6722	1058	37	1	366	1	GPR26	10	125426287	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	683752	125426287	10108460	110	4146											
PSMC3	5702	broad.mit.edu	37	chr11	47444246	47444246	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatgaacatctgcaccagctGggggccagccagctttagga	11	7	12	11	0	1	1	0	1	1	0	1	2	1	2	3	3	5	3	3	3	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:47444246G>C	uc001nfh.2	-	8	957	c.763C>G	c.(763-765)CAG>GAG	p.Q255E	PSMC3_uc009ylr.1_Missense_Mutation_p.Q213E	NM_002804	NP_002795	P17980	PRS6A_HUMAN	proteasome 26S ATPase subunit 3	255					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|nucleoside-triphosphatase activity|protein binding|transcription coactivator activity|transcription corepressor activity			ovary(4)	4				Lung(87;0.0932)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TGCACCAGCTGGGGGCCAGCC	0.547													29	110					0	0	0	0	C	47444246	C	C	47444246	3	2	18	1	0	0	0	0	1	0	0	0	12749	1357	47	4	576	4	PSMC3	11	47444246	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08		47444246	87562270	111	4147											
OR8J3	81168	broad.mit.edu	37	chr11	55905136	55905136	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggaatctggagctctggaCagctagagacacctgtgaga	11	7	15	8	0	2	2	0	1	2	2	2	7	2	5	1	4	2	2	1	4	2	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:55905136C>T	uc010riz.1	-	1	59	c.59G>A	c.(58-60)TGT>TAT	p.C20Y		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					GAGCTCTGGACAGCTAGAGAC	0.478													33	93					0	0	0	0	T	55905136	T	T	55905136	3	4	18	1	0	0	0	0	1	0	0	0	11296	478	17	4	890	4	OR8J3	11	55905136	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	8460890	55905136	79101380	112	4148											
OR8K5	219453	broad.mit.edu	37	chr11	55927085	55927085	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggaaccacatgtggagaaagCctttttcctgccctctgcag	9	10	10	12	0	1	1	0	0	1	1	2	3	2	2	4	2	4	1	4	2	2	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:55927085C>A	uc010rja.1	-	1	709	c.709G>T	c.(709-711)GCT>TCT	p.A237S		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				GTGGAGAAAGCCTTTTTCCTG	0.408													13	33					1.5842e-08	1.76231e-08	1	0	A	55927085	A	A	55927085	3	1	18	1	0	0	0	0	1	0	0	0	11299	739	26	4	217	4	OR8K5	11	55927085	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	21949	55927085	79079431	113	4149											
OR5M9	390162	broad.mit.edu	37	chr11	56230773	56230773	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaatatttcccaacagagtGatcatgtaaaccgctaggaa	15	9	7	10	1	1	2	1	1	0	1	2	3	2	3	3	1	2	2	3	1	7	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:56230773G>A	uc010rjj.1	-	1	105	c.105C>T	c.(103-105)ATC>ATT	p.I35I		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					CCAACAGAGTGATCATGTAAA	0.443													15	27					0	0	0	0	A	56230773	A	A	56230773	2	1	18	1	0	0	0	0	0	0	0	1	11231	1280	45	2		2	OR5M9	11	56230773	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	303688	56230773	78775743	114	4150											
CCDC87	55231	broad.mit.edu	37	chr11	66359037	66359037	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtactgccaacaaagttatCaatatccattttttcaatgg	14	14	5	8	0	2	0	2	0	0	0	3	0	3	0	2	1	3	2	2	1	7	6			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:66359037C>G	uc001oiq.3	-	1	1518	c.1450G>C	c.(1450-1452)GAT>CAT	p.D484H	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	484										ovary(1)|skin(1)	2						ACAAAGTTATCAATATCCATT	0.463													29	84					0	0	0	0	G	66359037	G	G	66359037	3	3	18	1	0	0	0	0	1	0	0	0	2875	826	29	2	1103	2	CCDC87	11	66359037	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	10128264	66359037	68647479	115	4151											
LRP5	4041	broad.mit.edu	37	chr11	68201226	68201226	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcccagttcccctgcgcgcGgggtcagtgtgtggacctgc	3	8	15	15	4	1	0	1	0	0	0	2	1	2	1	4	3	2	1	4	3	0	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:68201226G>A	uc001ont.2	+	18	3995	c.3920G>A	c.(3919-3921)CGG>CAG	p.R1307Q	LRP5_uc009ysg.2_Missense_Mutation_p.R717Q	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1307	LDL-receptor class A 2.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CCCTGCGCGCGGGGTCAGTGT	0.711													26	27					0	0	0	0	A	68201226	A	A	68201226	3	1	18	1	0	0	0	0	1	0	0	0	9010	1116	39	1	3990	1	LRP5	11	68201226	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	1842189	68201226	66805290	116	4152											
DDI1	414301	broad.mit.edu	37	chr11	103908425	103908425	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgggctggggttgctaaagGagtgggcacacagagaatta	11	8	17	5	0	0	1	0	0	0	1	0	3	0	2	0	5	1	4	0	5	4	3	rs142985363		TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:103908425G>A	uc001phr.2	+	1	1118	c.875G>A	c.(874-876)GGA>GAA	p.G292E	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	292					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GTTGCTAAAGGAGTGGGCACA	0.512													14	25					0	0	0	0	A	103908425	A	A	103908425	3	1	18	1	0	0	0	0	1	0	0	0	4345	1174	41	2	877	2	DDI1	11	103908425	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	35707199	103908425	31098091	117	4153											
CWF19L2	143884	broad.mit.edu	37	chr11	107207441	107207442	+	Splice_Site	INS	-	A	A																															caatgattttctgaacatctINSaaaaaaaaaaaagaactagg																										TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:107207441_107207442insA	uc010rvp.1	-	15	2233	c.2203_splice	c.e15-1	p.M735_splice	CWF19L2_uc001pjh.3_Splice_Site|CWF19L2_uc009yxo.2_Splice_Site	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control								catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TCTGAACATCTAAAAAAAAAAA	0.257													---	---	---								A	107207442	A	A	107207441	8	5	18	1	0	1	1	0	0	0	1	0	4089	1536	53	0	499	0	CWF19L2	11	107207441	Splice_Site	INS	-	TCGA-BA-6871-01A-11D-1870-08	3299016	107207441	27799075	118	4154											
SIK2	23235	broad.mit.edu	37	chr11	111571713	111571713	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttgaagggcagcagtatgaAggaccacagctggacatctg	12	8	13	8	0	1	2	0	2	1	0	1	4	1	4	1	3	2	4	1	3	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:111571713A>G	uc001plt.2	+	5	700	c.582A>G	c.(580-582)GAA>GAG	p.E194E		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	194	Protein kinase.				intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						AGCAGTATGAAGGACCACAGC	0.468													8	27					0	0	0	0	G	111571713	G	G	111571713	2	3	18	1	0	0	0	0	0	0	0	1	14383	69	3	5		5	SIK2	11	111571713	Silent	SNP	A	TCGA-BA-6871-01A-11D-1870-08	4364272	111571713	23434803	119	4155											
UBE4A	9354	broad.mit.edu	37	chr11	118260439	118260439	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agactttggattcttttccaGagatcaagtcactctttgtg	9	16	8	8	0	4	2	2	0	2	2	5	4	5	3	1	1	0	0	1	1	1	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:118260439G>A	uc001psw.2	+	17	2717	c.2588_splice	c.e17-1	p.E863_splice	UBE4A_uc001psv.2_Splice_Site_p.E870_splice	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TTCTTTTCCAGAGATCAAGTC	0.433													25	84					0	0	0	0	A	118260439	A	A	118260439	5	1	18	1	0	0	0	0	0	0	1	0	16950	956	33	2	2670	2	UBE4A	11	118260439	Splice_Site	SNP	G	TCGA-BA-6871-01A-11D-1870-08	6688726	118260439	16746077	120	4156											
ARCN1	372	broad.mit.edu	37	chr11	118468432	118468432	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcacaacaggtctggtgtcGgcgcgcctgttatcggtgag	6	10	14	11	4	2	1	1	1	1	0	4	1	2	1	1	4	1	1	1	4	2	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:118468432G>A	uc001ptq.2	+	9	1413	c.1252G>A	c.(1252-1254)GGC>AGC	p.G418S	ARCN1_uc009zah.2_Intron|ARCN1_uc010ryg.1_Missense_Mutation_p.G330S|ARCN1_uc009zag.2_Missense_Mutation_p.G459S	NM_001655	NP_001646	P48444	COPD_HUMAN	archain isoform 1	418	MHD.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GTCTGGTGTCGGCGCGCCTGT	0.493													4	22					0	0	0	0	A	118468432	A	A	118468432	3	1	18	1	0	0	0	0	1	0	0	0	842	1116	39	1	1286	1	ARCN1	11	118468432	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	207993	118468432	16538084	121	4157											
CRTAM	56253	broad.mit.edu	37	chr11	122724650	122724650	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaaaatccattttgttctaGcaactcctttcaagccaatc	13	13	4	11	0	2	0	1	0	1	0	5	1	4	0	3	0	3	2	3	0	6	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:122724650G>T	uc001pyj.2	+	4	347	c.347_splice	c.e4-1	p.A116_splice		NM_019604	NP_062550	O95727	CRTAM_HUMAN	class-I MHC-restricted T cell associated						cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			ovary(1)	1		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TTTTGTTCTAGCAACTCCTTT	0.398													10	35					3.07112e-06	3.31822e-06	1	0	T	122724650	T	T	122724650	5	4	18	1	0	0	0	0	0	0	1	0	3912	985	34	4	360	4	CRTAM	11	122724650	Splice_Site	SNP	G	TCGA-BA-6871-01A-11D-1870-08	4256218	122724650	12281866	122	4158											
VPS26B	112936	broad.mit.edu	37	chr11	134095034	134095034	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgatgagcttcttcggcttCgggcagagcgtggaggtgga	6	9	18	8	4	1	2	0	1	1	1	3	5	1	4	0	5	2	3	0	5	0	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr11:134095034C>T	uc001qhe.2	+	1	474	c.18C>T	c.(16-18)TTC>TTT	p.F6F	NCAPD3_uc001qhd.1_5'Flank|NCAPD3_uc010scm.1_5'Flank|NCAPD3_uc009zda.1_5'Flank|NCAPD3_uc010scn.1_5'Flank	NM_052875	NP_443107	Q4G0F5	VP26B_HUMAN	vacuolar protein sorting 26 homolog B	6					protein transport|vacuolar transport	cytosol|retromer complex					0	all_hematologic(175;0.127)	all_cancers(12;1.1e-21)|all_epithelial(12;3.77e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;2.43e-10)|all cancers(11;2.94e-09)|BRCA - Breast invasive adenocarcinoma(10;9.57e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00164)|Lung(977;0.216)		TCTTCGGCTTCGGGCAGAGCG	0.627													5	10					0	0	0	0	T	134095034	T	T	134095034	2	4	18	1	0	0	0	0	0	0	0	1	17266	883	31	1		1	VPS26B	11	134095034	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08	11370384	134095034	911482	123	4159											
ERC1	23085	broad.mit.edu	37	chr12	1250924	1250924	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggacatgttggatgtgaagGagcggaaggttaatgttctt	11	12	15	3	1	1	1	0	1	1	0	1	5	1	5	0	5	1	3	0	5	3	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr12:1250924G>T	uc001qjb.2	+	8	1949	c.1708G>T	c.(1708-1710)GAG>TAG	p.E570*	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Nonsense_Mutation_p.E542*|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Nonsense_Mutation_p.E570*|ERC1_uc010sdv.1_Nonsense_Mutation_p.E318*|ERC1_uc009zdp.2_Nonsense_Mutation_p.E210*	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	570	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GGATGTGAAGGAGCGGAAGGT	0.423													16	275					1.15088e-07	1.26529e-07	1	0	T	1250924	T	T	1250924	4	4	18	1	0	0	0	0	0	1	0	0	5234	1175	41	2	1734	2	ERC1	12	1250924	Nonsense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08		1250924	132600971	124	4160											
NCAPD2	9918	broad.mit.edu	37	chr12	6639016	6639016	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagcgaggcctccgtaagatGcttgacaattttgactgttt	9	13	11	8	2	0	3	0	2	0	1	1	5	1	3	2	1	2	3	2	1	2	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr12:6639016G>C	uc001qoo.2	+	29	3775	c.3729G>C	c.(3727-3729)ATG>ATC	p.M1243I	NCAPD2_uc010sfd.1_Missense_Mutation_p.M1198I	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	1243					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						TCCGTAAGATGCTTGACAATT	0.532													392	84					0	0	0	0	C	6639016	C	C	6639016	3	2	18	1	0	0	0	0	1	0	0	0	10259	1319	46	4	3839	4	NCAPD2	12	6639016	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	5388092	6639016	127212879	125	4161											
DDX11	1663	broad.mit.edu	37	chr12	31253973	31253973	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttaccaggtcacgtgatccCtccagacaacatcctgcccc	9	8	6	18	1	1	2	1	1	0	1	4	2	4	2	6	1	3	0	6	1	2	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr12:31253973C>T	uc001rjt.1	+	20	2212	c.1961C>T	c.(1960-1962)CCT>CTT	p.P654L	DDX11_uc001rjr.1_Missense_Mutation_p.P654L|DDX11_uc001rjs.1_Missense_Mutation_p.P654L|DDX11_uc001rju.1_Intron|DDX11_uc001rjv.1_Missense_Mutation_p.P654L|DDX11_uc001rjw.1_Missense_Mutation_p.P628L|DDX11_uc009zjn.1_RNA|DDX11_uc009zjo.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	654					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CACGTGATCCCTCCAGACAAC	0.582										Multiple Myeloma(12;0.14)			15	114					0	0	0	0	T	31253973	T	T	31253973	3	4	18	1	0	0	0	0	1	0	0	0	4360	681	24	4	2035	4	DDX11	12	31253973	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	24614957	31253973	102597922	126	4162											
MLL2	8085	broad.mit.edu	37	chr12	49441813	49441813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaggcaaggaggtggccctCtgccccccggccaaagctgc	8	4	13	16	1	1	0	0	0	1	0	1	1	1	1	5	5	3	2	5	5	2	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr12:49441813C>T	uc001rta.3	-	14	4171	c.4171G>A	c.(4171-4173)GAG>AAG	p.E1391K		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1391	PHD-type 3.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGGTGGCCCTCTGCCCCCCGG	0.562			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			31	49					0	0	0	0	T	49441813	T	T	49441813	3	4	18	1	0	0	0	0	1	0	0	0	9674	922	32	2	12606	2	MLL2	12	49441813	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	18187840	49441813	84410082	127	4163											
STAT2	6773	broad.mit.edu	37	chr12	56743976	56743976	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgttgaacttccggaagcTgttccaggaggaagatacat	13	10	11	7	1	0	2	0	1	0	1	2	5	2	5	2	3	3	3	2	3	5	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr12:56743976T>A	uc001slc.2	-	13	1194	c.1116_splice	c.e13-1	p.G372_splice	STAT2_uc001slb.2_5'Flank|STAT2_uc001sld.2_Splice_Site_p.G368_splice|STAT2_uc010sqn.1_Splice_Site_p.G368_splice	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription						interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TTCCGGAAGCTGTTCCAGGAG	0.423													29	83					0	0	0	0	A	56743976	A	A	56743976	5	1	18	1	0	0	0	0	0	0	1	0	15331	1594	55	5	1489	5	STAT2	12	56743976	Splice_Site	SNP	T	TCGA-BA-6871-01A-11D-1870-08	7302163	56743976	77107919	128	4164											
NR2C1	7181	broad.mit.edu	37	chr12	95451597	95451597	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agattttttctgttgaagcgGcacagttggaagatttttct	9	17	10	5	1	2	3	0	1	2	2	2	4	2	4	0	2	1	3	0	2	2	7			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr12:95451597G>A	uc001tdm.3	-	6	858	c.602C>T	c.(601-603)GCC>GTC	p.A201V	NR2C1_uc010suu.1_Missense_Mutation_p.A201V|NR2C1_uc001tdo.3_Missense_Mutation_p.A201V|NR2C1_uc001tdn.3_Missense_Mutation_p.A201V	NM_003297	NP_003288	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	201					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1						TGTTGAAGCGGCACAGTTGGA	0.343													4	147					0	0	0	0	A	95451597	A	A	95451597	3	1	18	1	0	0	0	0	1	0	0	0	10676	1203	42	4	1323	4	NR2C1	12	95451597	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	38707621	95451597	38400298	129	4165											
RIMBP2	23504	broad.mit.edu	37	chr12	130921646	130921646	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaacttgctaatggctttGattggggtgcaggtctcggg	7	12	15	7	1	1	2	0	1	1	1	2	2	1	2	0	5	3	3	0	5	2	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr12:130921646G>C	uc001uil.2	-	10	1960	c.1796C>G	c.(1795-1797)TCA>TGA	p.S599*	RIMBP2_uc001uim.2_Nonsense_Mutation_p.S507*|RIMBP2_uc001uin.1_Nonsense_Mutation_p.S258*	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	599	Pro-rich.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TAATGGCTTTGATTGGGGTGC	0.652													4	16					0	0	0	0	C	130921646	C	C	130921646	4	2	18	1	0	0	0	0	0	1	0	0	13428	1294	45	2	1402	2	RIMBP2	12	130921646	Nonsense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	35470049	130921646	2930249	130	4166											
NBEA	26960	broad.mit.edu	37	chr13	35685031	35685031	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatacgcagagtaggaacaGtattacagctaatgcacacc	15	7	8	11	1	0	1	0	0	0	1	0	2	0	2	2	1	5	5	2	1	6	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr13:35685031G>C	uc001uvb.2	+	14	2124	c.1918G>C	c.(1918-1920)GTA>CTA	p.V640L		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	640						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AGTAGGAACAGTATTACAGCT	0.373													19	43					0	0	0	0	C	35685031	C	C	35685031	3	2	18	1	0	0	0	0	1	0	0	0	10240	1029	36	4	1968	4	NBEA	13	35685031	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08		35685031	79484847	131	4167											
SLITRK5	26050	broad.mit.edu	37	chr13	88330088	88330088	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccccgccgcagctgcagctGcagcccggggaggaggagag	7	2	17	15	3	0	1	0	0	0	1	0	4	0	3	4	4	5	5	4	4	0	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr13:88330088G>A	uc001vln.2	+	2	2664	c.2445G>A	c.(2443-2445)CTG>CTA	p.L815L	SLITRK5_uc010tic.1_Silent_p.L574L	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	815	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					agctgcagctgcagcCCGGGG	0.428													3	6					0	0	0	0	A	88330088	A	A	88330088	2	1	18	1	0	0	0	0	0	0	0	1	14810	1306	46	4		4	SLITRK5	13	88330088	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	52645057	88330088	26839790	132	4168											
IPO5	3843	broad.mit.edu	37	chr13	98668033	98668033	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgaagagtcactacaagatGaggtaagttattccctttgg	12	12	10	7	1	1	3	1	1	0	2	3	4	2	3	1	2	1	2	1	2	5	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr13:98668033G>A	uc001vne.2	+	24	2725	c.2545G>A	c.(2545-2547)GAG>AAG	p.E849K		NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	831					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						ACTACAAGATGAGGTAAGTTA	0.358													11	27					0	0	0	0	A	98668033	A	A	98668033	3	1	18	1	0	0	0	0	1	0	0	0	7835	1291	45	2	2631	2	IPO5	13	98668033	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	10337945	98668033	16501845	133	4169											
C14orf104	55172	broad.mit.edu	37	chr14	50092739	50092739	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctttcctcctttccttgtaGctgatcagagttactacatt	7	18	5	11	0	2	2	1	1	1	1	5	2	5	2	3	0	3	3	3	0	3	7			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr14:50092739G>A	uc001wws.3	-	3	2116	c.2035C>T	c.(2035-2037)CTA>TTA	p.L679L	SDCCAG1_uc010anj.1_Intron|C14orf104_uc001wwt.3_Silent_p.L631L	NM_018139	NP_060609	Q9NVR5	KTU_HUMAN	kintoun isoform 1	679					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm					0	all_epithelial(31;0.0021)|Breast(41;0.0124)					TTTCCTTGTAGCTGATCAGAG	0.299									Kartagener_syndrome				3	8					0	0	0	0	A	50092739	A	A	50092739	2	1	18	1	0	0	0	0	0	0	0	1	1742	962	34	4		4	C14orf104	14	50092739	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08		50092739	57256801	134	4170											
PPP2R5E	5529	broad.mit.edu	37	chr14	63860550	63860550	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcctacctgtgcatggaaGagtgataagctcctgacagt	10	10	10	11	0	0	3	0	2	0	1	2	4	2	4	4	1	3	2	4	1	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr14:63860550G>C	uc001xgd.1	-	8	1427	c.837C>G	c.(835-837)CTC>CTG	p.L279L	PPP2R5E_uc010tsf.1_Silent_p.L203L|PPP2R5E_uc010tsg.1_Silent_p.L203L|PPP2R5E_uc001xge.2_Silent_p.L279L|PPP2R5E_uc010tsh.1_Silent_p.L279L|PPP2R5E_uc001xgf.1_RNA	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	279					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		GTGCATGGAAGAGTGATAAGC	0.343													6	10					0	0	0	0	C	63860550	C	C	63860550	2	2	18	1	0	0	0	0	0	0	0	1	12456	929	33	2		2	PPP2R5E	14	63860550	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	13767811	63860550	43488990	135	4171											
SMEK1	55671	broad.mit.edu	37	chr14	91948149	91948149	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttttcgtggttgtgataaaGcaggatcatattctaaacat	12	15	9	5	1	2	1	1	1	1	0	3	2	2	2	0	2	2	3	0	2	5	7			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr14:91948149G>A	uc001xzn.2	-	4	1508	c.686C>T	c.(685-687)GCT>GTT	p.A229V	SMEK1_uc001xzm.2_Missense_Mutation_p.A229V|SMEK1_uc001xzo.2_Missense_Mutation_p.A229V|SMEK1_uc010atz.2_Intron|SMEK1_uc001xzp.1_RNA|SMEK1_uc001xzq.1_Missense_Mutation_p.A105V	NM_032560	NP_115949	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1	229						microtubule organizing center|nucleus	protein binding				0		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		TTGTGATAAAGCAGGATCATA	0.348													19	38					0	0	0	0	A	91948149	A	A	91948149	3	1	18	1	0	0	0	0	1	0	0	0	14857	971	34	4	1824	4	SMEK1	14	91948149	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	28087599	91948149	15401391	136	4172											
ATP10A	57194	broad.mit.edu	37	chr15	25966813	25966813	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagactcaccatttgcatCatgagaatattctacaccag	13	10	5	13	0	3	2	2	1	1	2	3	3	3	2	3	0	2	1	3	0	3	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr15:25966813C>G	uc010ayu.2	-	7	1460	c.1354G>C	c.(1354-1356)GAT>CAT	p.D452H		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	452	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CCATTTGCATCATGAGAATAT	0.418													17	69					0	0	0	0	G	25966813	G	G	25966813	3	3	18	1	0	0	0	0	1	0	0	0	1118	826	29	2	3205	2	ATP10A	15	25966813	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08		25966813	76564579	137	4173											
HERC2	8924	broad.mit.edu	37	chr15	28358347	28358347	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacctcccagaaccactggAtcagcgatgcggaaggctcg	10	6	11	14	3	2	1	2	0	0	1	4	4	3	3	3	3	3	1	3	3	2	0			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr15:28358347A>G	uc001zbj.2	-	92	14208	c.14102T>C	c.(14101-14103)ATC>ACC	p.I4701T	HERC2_uc001zbi.2_Missense_Mutation_p.I390T	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4701	HECT.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GAACCACTGGATCAGCGATGC	0.607													11	48					0	0	0	0	G	28358347	G	G	28358347	3	3	18	1	0	0	0	0	1	0	0	0	7097	333	12	5	410	5	HERC2	15	28358347	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	2391534	28358347	74173045	138	4174											
CGNL1	84952	broad.mit.edu	37	chr15	57815716	57815716	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtcagactacccaggagcaGaagcagttgtctgagaagct	13	7	12	9	0	2	3	1	1	1	3	2	5	2	4	1	1	4	4	1	1	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr15:57815716G>A	uc002aeg.2	+	11	2821	c.2745G>A	c.(2743-2745)CAG>CAA	p.Q915Q	CGNL1_uc010bfw.2_Silent_p.Q915Q	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	915	Potential.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		CCCAGGAGCAGAAGCAGTTGT	0.532													43	20					0	0	0	0	A	57815716	A	A	57815716	2	1	18	1	0	0	0	0	0	0	0	1	3319	933	33	2		2	CGNL1	15	57815716	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	29457369	57815716	44715676	139	4175											
GRIN2A	2903	broad.mit.edu	37	chr16	10274118	10274118	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggggccccacagtgttcgaaGttcgcgctctgtcacgtcgt	5	10	13	13	5	2	0	1	0	1	0	5	1	2	0	2	2	0	3	2	2	1	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr16:10274118G>C	uc002czo.3	-	2	699	c.151C>G	c.(151-153)CTT>GTT	p.L51V	GRIN2A_uc010uym.1_Missense_Mutation_p.L51V|GRIN2A_uc002czr.3_Missense_Mutation_p.L51V|GRIN2A_uc010buk.2_Missense_Mutation_p.L51V	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	51	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGTGTTCGAAGTTCGCGCTCT	0.682													16	93					0	0	0	0	C	10274118	C	C	10274118	3	2	18	1	0	0	0	0	1	0	0	0	6818	1029	36	4	4291	4	GRIN2A	16	10274118	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08		10274118	80080635	140	4176											
ZKSCAN2	342357	broad.mit.edu	37	chr16	25268325	25268325	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagcatttgcggaaggtctCagagctatccgatccttcca	10	10	10	11	2	1	1	1	0	1	1	5	4	4	2	3	2	3	2	3	2	3	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr16:25268325C>G	uc002dod.3	-	1	531	c.124G>C	c.(124-126)GAG>CAG	p.E42Q	ZKSCAN2_uc010vcl.1_5'UTR|ZKSCAN2_uc002doe.2_Missense_Mutation_p.E42Q	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	42					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		CGGAAGGTCTCAGAGCTATCC	0.522											OREG0023690	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	40					0	0	0	0	G	25268325	G	G	25268325	3	3	18	1	0	0	0	0	1	0	0	0	17754	835	29	2	2807	2	ZKSCAN2	16	25268325	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	14994207	25268325	65086428	141	4177											
CPNE2	221184	broad.mit.edu	37	chr16	57149418	57149418	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaagaagatcactaggcctCtgctgctgctgaatgacaag	12	8	11	10	0	2	4	1	2	1	2	2	4	2	4	1	1	3	4	1	1	5	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr16:57149418C>T	uc002eks.1	+	4	620	c.391C>T	c.(391-393)CTG>TTG	p.L131L	CPNE2_uc010cct.1_Silent_p.L157L|CPNE2_uc010ccu.1_Silent_p.L131L	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	131										central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				CACTAGGCCTCTGCTGCTGCT	0.622													14	46					0	0	0	0	T	57149418	T	T	57149418	2	4	18	1	0	0	0	0	0	0	0	1	3827	912	32	2		2	CPNE2	16	57149418	Silent	SNP	C	TCGA-BA-6871-01A-11D-1870-08	31881093	57149418	33205335	142	4178											
CPNE2	221184	broad.mit.edu	37	chr16	57153158	57153158	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agttttataagccaggagacGatggcaagtggatgctggtc	11	10	14	6	1	0	1	0	0	0	1	1	4	0	2	1	4	2	3	1	4	3	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr16:57153158G>A	uc002eks.1	+	6	788	c.559G>A	c.(559-561)GAT>AAT	p.D187N	CPNE2_uc010cct.1_Missense_Mutation_p.D213N|CPNE2_uc010ccu.1_Missense_Mutation_p.D187N	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	187	C2 2.									central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				GCCAGGAGACGATGGCAAGTG	0.587													30	90					0	0	0	0	A	57153158	A	A	57153158	3	1	18	1	0	0	0	0	1	0	0	0	3827	1058	37	1	577	1	CPNE2	16	57153158	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	3740	57153158	33201595	143	4179											
OR3A2	4995	broad.mit.edu	37	chr17	3181289	3181289	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcagtgatctcctccccaaaAatatttgccacagagcaccc	12	9	5	15	0	2	2	1	1	1	1	4	2	3	2	5	0	2	1	5	0	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr17:3181289A>C	uc002fvg.2	-	1	980	c.941T>G	c.(940-942)TTT>TGT	p.F314C		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	314	Cytoplasmic (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CCTCCCCAAAAATATTTGCCA	0.463													8	48					0	0	0	0	C	3181289	C	C	3181289	3	2	18	1	0	0	0	0	1	0	0	0	11092	14	1	5	28	5	OR3A2	17	3181289	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08		3181289	78013921	144	4180											
ZNF594	84622	broad.mit.edu	37	chr17	5085147	5085147	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctatgatgtctcagaaggtCtgagctctgattgagttttc	8	16	10	7	0	4	5	1	4	4	1	6	5	4	5	0	1	1	2	0	1	2	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr17:5085147C>G	uc010cla.1	-	2	2561	c.2405G>C	c.(2404-2406)AGA>ACA	p.R802T		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	802					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						CTCAGAAGGTCTGAGCTCTGA	0.403													40	114					0	0	0	0	G	5085147	G	G	5085147	3	3	18	1	0	0	0	0	1	0	0	0	18091	913	32	2	22	2	ZNF594	17	5085147	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	1903858	5085147	76110063	145	4181											
ZNF624	57547	broad.mit.edu	37	chr17	16527489	16527489	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccaaatgggtatctgtaatCaaatttaaattctctgtgaa	14	14	6	7	0	3	1	1	1	2	0	4	1	3	1	1	1	0	2	1	1	7	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr17:16527489C>G	uc010cpi.1	-	6	794	c.711G>C	c.(709-711)TTG>TTC	p.L237F		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	237					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TATCTGTAATCAAATTTAAAT	0.383													22	66					0	0	0	0	G	16527489	G	G	16527489	3	3	18	1	0	0	0	0	1	0	0	0	18115	825	29	2	1890	2	ZNF624	17	16527489	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	11442342	16527489	64667721	146	4182											
PROCA1	147011	broad.mit.edu	37	chr17	27038611	27038611	+	5'Flank	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggcatctgctctcatcccacGagcgggccttgggctcggtc	4	9	13	15	3	2	0	1	0	2	0	6	1	3	0	2	4	2	3	2	4	0	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr17:27038611G>C	uc002hcb.3	-						PROCA1_uc010crv.2_5'Flank|PROCA1_uc002hca.1_Missense_Mutation_p.S23W	NM_152465	NP_689678	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1						lipid catabolic process		calcium ion binding|phospholipase A2 activity			ovary(1)	1	Lung NSC(42;0.00431)					CTCATCCCACGAGCGGGCCTT	0.672													6	209					0	0	0	0	C	27038611	C	C	27038611	1	2	18	0	1	0	0	0	0	0	0	0	12608	1059	37	3		3	PROCA1	17	27038611	5'Flank	SNP	G	TCGA-BA-6871-01A-11D-1870-08	10511122	27038611	54156599	147	4183											
RPTOR	57521	broad.mit.edu	37	chr17	78858859	78858859	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgttcgtgggcaactctgcaGagaggacggaccactccacc	9	6	12	14	3	1	1	0	0	1	1	3	4	2	3	3	3	2	3	3	3	1	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr17:78858859G>C	uc002jyt.1	+	17	2699	c.1894G>C	c.(1894-1896)GAG>CAG	p.E632Q	RPTOR_uc010wug.1_Intron	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	632					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CAACTCTGCAGAGAGGACGGA	0.672													4	13					0	0	0	0	C	78858859	C	C	78858859	3	2	18	1	0	0	0	0	1	0	0	0	13730	943	33	2	1960	2	RPTOR	17	78858859	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	51820248	78858859	2336351	148	4184											
SETBP1	26040	broad.mit.edu	37	chr18	42530340	42530340	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaaagatgtgataagtcaGaccataccaaacccagacct	19	6	6	10	0	1	4	1	1	0	3	1	4	1	4	4	0	2	0	4	0	6	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr18:42530340G>A	uc010dni.2	+	4	1331	c.1035G>A	c.(1033-1035)CAG>CAA	p.Q345Q		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	345						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TGATAAGTCAGACCATACCAA	0.483									Schinzel-Giedion_syndrome				13	35					0	0	0	0	A	42530340	A	A	42530340	2	1	18	1	0	0	0	0	0	0	0	1	14194	933	33	2		2	SETBP1	18	42530340	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08		42530340	35546908	149	4185											
TRIP10	9322	broad.mit.edu	37	chr19	6743214	6743214	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttctgtagcacttccaaGaagggcggcgggcccagcag	8	8	13	12	2	2	1	0	0	2	1	3	1	3	1	2	3	2	3	2	3	3	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr19:6743214G>C	uc002mfs.2	+	5	421	c.355G>C	c.(355-357)GAA>CAA	p.E119Q	TRIP10_uc010dux.1_Missense_Mutation_p.E119Q|TRIP10_uc002mfr.2_Missense_Mutation_p.E119Q|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_5'UTR	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	119	Potential.|Induction of membrane tubulation.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						GCACTTCCAAGAAGGGCGGCG	0.562													9	16					0	0	0	0	C	6743214	C	C	6743214	3	2	18	1	0	0	0	0	1	0	0	0	16621	943	33	2	373	2	TRIP10	19	6743214	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08		6743214	52385769	150	4186											
COL5A3	50509	broad.mit.edu	37	chr19	10107155	10107155	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggcctgctggaatgagActggggggcctttaaaggag	8	8	17	8	0	0	1	0	1	0	1	0	4	0	3	3	6	1	1	3	6	3	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr19:10107155A>T	uc002mmq.1	-	13	1462	c.1376T>A	c.(1375-1377)GTC>GAC	p.V459D		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	459	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CTGGAATGAGACTGGGGGGCC	0.597													13	41					0	0	0	0	T	10107155	T	T	10107155	3	4	18	1	0	0	0	0	1	0	0	0	3713	275	10	5	4081	5	COL5A3	19	10107155	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	3363941	10107155	49021828	151	4187											
JAK3	3718	broad.mit.edu	37	chr19	17942159	17942159	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctctccacgaggatgtttcgGgcggccaggtcgcggtgcac	5	8	15	13	5	1	0	0	0	1	0	4	2	1	1	2	5	1	2	2	5	0	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr19:17942159G>T	uc002nhn.3	-	21	2956	c.2856C>A	c.(2854-2856)GCC>GCA	p.A952A	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Silent_p.A952A	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	952	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						GGATGTTTCGGGCGGCCAGGT	0.652		2	Mis		acute megakaryocytic leukemia|								26	107					5.77227e-19	6.69868e-19	1	0	T	17942159	T	T	17942159	2	4	18	1	0	0	0	0	0	0	0	1	7978	1219	43	4		4	JAK3	19	17942159	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	7835004	17942159	41186824	152	4188											
KIAA1683	80726	broad.mit.edu	37	chr19	18377335	18377335	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactggatatgtctggagtaGagtcttggtgatcatgggcc	8	12	14	7	0	3	2	1	1	2	1	3	4	3	4	1	4	0	1	1	4	2	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr19:18377335G>C	uc002nin.2	-	3	1231	c.1015C>G	c.(1015-1017)CTA>GTA	p.L339V	KIAA1683_uc010ebn.2_Missense_Mutation_p.L339V|KIAA1683_uc010xqe.1_Missense_Mutation_p.L293V	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	339	Thr-rich.					mitochondrion				ovary(2)	2						GTCTGGAGTAGAGTCTTGGTG	0.567													13	53					0	0	0	0	C	18377335	C	C	18377335	3	2	18	1	0	0	0	0	1	0	0	0	8290	933	33	2	3096	2	KIAA1683	19	18377335	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	435176	18377335	40751648	153	4189											
ZNF383	163087	broad.mit.edu	37	chr19	37733511	37733511	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagatgttttggaatatagaAgccaccttgcaaaacaactg	15	10	9	7	0	0	2	0	0	0	2	0	4	0	3	2	1	4	2	2	1	7	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr19:37733511A>G	uc002oft.1	+	8	953	c.373A>G	c.(373-375)AGC>GGC	p.S125G	ZNF383_uc002ofs.1_Missense_Mutation_p.S60G|ZNF383_uc002ofu.1_Missense_Mutation_p.S125G	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGAATATAGAAGCCACCTTGC	0.383													46	87					0	0	0	0	G	37733511	G	G	37733511	3	3	18	1	0	0	0	0	1	0	0	0	17941	72	3	5	387	5	ZNF383	19	37733511	Missense_Mutation	SNP	A	TCGA-BA-6871-01A-11D-1870-08	19356176	37733511	21395472	154	4190											
SAMD4B	55095	broad.mit.edu	37	chr19	39860463	39860463	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgctttcatcgaggagaGtcgccagctgctttcctatg	8	12	10	11	2	1	1	1	0	0	1	4	3	2	1	2	1	3	3	2	1	2	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr19:39860463G>A	uc002olb.2	+	6	1400	c.365G>A	c.(364-366)AGT>AAT	p.S122N	SAMD4B_uc002ola.2_Missense_Mutation_p.S122N	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	122							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			ATCGAGGAGAGTCGCCAGCTG	0.587													9	22					0	0	0	0	A	39860463	A	A	39860463	3	1	18	1	0	0	0	0	1	0	0	0	13887	1029	36	4	371	4	SAMD4B	19	39860463	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	2126952	39860463	19268520	155	4191											
CCDC114	93233	broad.mit.edu	37	chr19	48800482	48800482	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgaggcactggtggagccGaaggtcacgtggccagtgtt	7	8	16	10	3	1	0	1	0	0	0	2	3	1	1	2	5	1	2	2	5	1	1			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr19:48800482G>A	uc002pir.2	-	14	2447	c.1764C>T	c.(1762-1764)TTC>TTT	p.F588F	CCDC114_uc002piq.2_Silent_p.F397F|CCDC114_uc002pio.2_3'UTR	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	588										ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		TGGTGGAGCCGAAGGTCACGT	0.657													13	18					0	0	0	0	A	48800482	A	A	48800482	2	1	18	1	0	0	0	0	0	0	0	1	2763	1049	37	1		1	CCDC114	19	48800482	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	8940019	48800482	10328501	156	4192											
GPR32	2854	broad.mit.edu	37	chr19	51273921	51273921	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctggggtcctgacacgtGatcgctcttgttccaggaag	8	10	12	11	2	1	2	0	2	1	0	4	3	3	3	3	3	1	2	3	3	2	2			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr19:51273921G>A	uc010ycf.1	+	1	64	c.64G>A	c.(64-66)GAT>AAT	p.D22N		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	22	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CCTGACACGTGATCGCTCTTG	0.527													11	15					0	0	0	0	A	51273921	A	A	51273921	3	1	18	1	0	0	0	0	1	0	0	0	6726	1290	45	2	66	2	GPR32	19	51273921	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08	2473439	51273921	7855062	157	4193											
C20orf194	25943	broad.mit.edu	37	chr20	3311319	3311319	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcagttttcttgggcagcttGctgtcaccacctgtgaaaga	8	13	10	10	0	3	2	2	1	1	1	3	2	3	2	2	1	2	4	2	1	1	4			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chr20:3311319G>T	uc002wii.2	-	12	1125	c.1074C>A	c.(1072-1074)AGC>AGA	p.S358R	C20orf194_uc002wij.3_Missense_Mutation_p.S97R|C20orf194_uc002wik.2_Missense_Mutation_p.S32R|C20orf194_uc010gay.1_RNA	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	358											0						TGGGCAGCTTGCTGTCACCAC	0.388													7	17					0.00307968	0.00323452	1	0	T	3311319	T	T	3311319	3	4	18	1	0	0	0	0	1	0	0	0	2109	1310	46	4	2563	4	C20orf194	20	3311319	Missense_Mutation	SNP	G	TCGA-BA-6871-01A-11D-1870-08		3311319	59714201	158	4194											
PRDX4	10549	broad.mit.edu	37	chrX	23700512	23700512	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccattcttctgttttacaGaggtctcttcattattgatg	8	19	6	8	0	4	2	1	1	3	1	5	2	4	2	1	1	2	1	1	1	3	8			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chrX:23700512G>A	uc004dam.2	+	5	643	c.600_splice	c.e5-1	p.R200_splice		NM_006406	NP_006397	Q13162	PRDX4_HUMAN	peroxiredoxin 4						cell redox homeostasis|I-kappaB phosphorylation		thioredoxin peroxidase activity			upper_aerodigestive_tract(1)	1						CTGTTTTACAGAGGTCTCTTC	0.368													16	25					0	0	0	0	A	23700512	A	A	23700512	5	1	18	1	0	0	0	0	0	0	1	0	12529	956	33	2	617	2	PRDX4	23	23700512	Splice_Site	SNP	G	TCGA-BA-6871-01A-11D-1870-08		23700512	131570048	159	4195											
RPGR	6103	broad.mit.edu	37	chrX	38145068	38145068	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttcccctcttcttcctcctCctcttctctgttcctcctgt	0	19	2	20	0	4	0	0	0	4	0	11	0	10	0	7	0	0	1	7	0	0	5			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chrX:38145068C>G	uc004ded.1	-	15	3352	c.3184G>C	c.(3184-3186)GAG>CAG	p.E1062Q	RPGR_uc004deb.2_Intron|RPGR_uc004dea.2_Intron|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						tcttcctcctcctcttctctg	0.189													39	31					0	0	0	0	G	38145068	G	G	38145068	3	3	18	1	0	0	0	0	1	0	0	0	13613	864	30	2	837	2	RPGR	23	38145068	Missense_Mutation	SNP	C	TCGA-BA-6871-01A-11D-1870-08	14444556	38145068	117125492	160	4196											
ZNF41	7592	broad.mit.edu	37	chrX	47306830	47306831	+	Frame_Shift_Del	DEL	CA	-	-																															tttccaggtgaagactttctCagtcactggctttatagcgt																										TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chrX:47306830_47306831delCA	uc004dhs.3	-	4	2531_2532	c.2464_2465delTG	c.(2464-2466)TGAfs	p.*822fs	ZNF41_uc004dhu.3_Frame_Shift_Del_p.*814fs|ZNF41_uc004dht.3_Frame_Shift_Del_p.*694fs|ZNF41_uc004dhv.3_Frame_Shift_Del_p.*790fs|ZNF41_uc004dhw.3_Frame_Shift_Del_p.*782fs|ZNF41_uc004dhy.3_Frame_Shift_Del_p.*780fs|ZNF41_uc004dhx.3_Frame_Shift_Del_p.*780fs|ZNF41_uc011mlm.1_Frame_Shift_Del_p.*694fs	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	822						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				AAGACTTTCTCAGTCACTGGCT	0.431													---	---	---								-	47306831	-	-	47306830	7	5	18	1	0	1	0	1	0	0	0	0	17956	837	29	0	4	0	ZNF41	23	47306830	Frame_Shift_Del	DEL	CA	TCGA-BA-6871-01A-11D-1870-08	9161762	47306830	107963730	161	4197											
HUWE1	10075	broad.mit.edu	37	chrX	53631658	53631658	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtagcatcagcaacattGcctgcgcaagccagttctcg	10	8	11	12	2	2	0	1	0	1	0	3	0	2	0	2	1	6	5	2	1	3	3			TCGA-BA-6871-01A-11D-1870-08	TCGA-BA-6871-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8a04117-0ebc-4c27-83d6-441be47e5fd3	4c569302-a5d1-4106-aec8-c3c4e815de8e	g.chrX:53631658G>A	uc004dsp.2	-	26	3036	c.2634C>T	c.(2632-2634)GGC>GGT	p.G878G		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	878					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CAGCAACATTGCCTGCGCAAG	0.562													8	17					0	0	0	0	A	53631658	A	A	53631658	2	1	18	1	0	0	0	0	0	0	0	1	7500	1306	46	4		4	HUWE1	23	53631658	Silent	SNP	G	TCGA-BA-6871-01A-11D-1870-08	6324828	53631658	101638902	162	4198											
CLCNKB	1188	broad.mit.edu	37	chr1	16380141	16380141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctgcctgcagttcccacCgcgtgagggtggagcacttc	5	9	12	15	2	1	1	0	1	1	0	3	2	2	2	4	2	3	3	4	2	0	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:16380141C>T	uc001axw.3	+	16	1710	c.1630C>T	c.(1630-1632)CGC>TGC	p.R544C	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.R544C|CLCNKB_uc001axy.3_Missense_Mutation_p.R375C	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	544					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTTCCCACCGCGTGAGGGT	0.622													3	67					0	0	0	0	T	16380141	T	T	16380141	3	4	19	1	0	0	0	0	1	0	0	0	3485	652	23	1	1836	1	CLCNKB	1	16380141	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08		16380141	232870480	1	4199											
CYP4A11	1579	broad.mit.edu	37	chr1	47398701	47398701	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtggtgaaggccataaatgGagaggaggaccatgatacct	13	8	14	6	0	0	3	0	2	0	1	0	6	0	5	3	5	1	0	3	5	4	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:47398701G>A	uc001cqp.3	-	10	1292	c.1241C>T	c.(1240-1242)TCC>TTC	p.S414F	CYP4A11_uc001cqq.2_Missense_Mutation_p.S414F	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	414					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GCCATAAATGGAGAGGAGGAC	0.507													84	357					0	0	0	0	A	47398701	A	A	47398701	3	1	19	1	0	0	0	0	1	0	0	0	4200	1174	41	2	330	2	CYP4A11	1	47398701	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	31018560	47398701	201851920	2	4200											
LEPR	3953	broad.mit.edu	37	chr1	66064395	66064395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtagacagtatacttcctgGgtcttcgtatgaggttcagg	9	13	12	7	1	2	2	1	1	1	1	4	2	3	2	1	3	1	4	1	3	4	7			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:66064395G>A	uc001dci.2	+	8	1104	c.902G>A	c.(901-903)GGG>GAG	p.G301E	LEPR_uc001dcg.2_Missense_Mutation_p.G301E|LEPR_uc001dch.2_Missense_Mutation_p.G301E|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.G301E|LEPR_uc001dck.2_Missense_Mutation_p.G301E	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	301	Extracellular (Potential).|Fibronectin type-III 1.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ATACTTCCTGGGTCTTCGTAT	0.413													17	48					0	0	0	0	A	66064395	A	A	66064395	3	1	19	1	0	0	0	0	1	0	0	0	8768	1232	43	4	924	4	LEPR	1	66064395	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	18665694	66064395	183186226	3	4201											
IL12RB2	3595	broad.mit.edu	37	chr1	67793933	67793933	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaagcaatgtaaagacatttAttgtgactatttggactttg	13	15	9	4	0	0	2	0	1	0	1	0	4	0	3	0	1	1	2	0	1	6	7			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:67793933A>C	uc001ddu.2	+	5	1170	c.530A>C	c.(529-531)TAT>TCT	p.Y177S	IL12RB2_uc010oqi.1_Missense_Mutation_p.Y177S|IL12RB2_uc010oqj.1_Missense_Mutation_p.Y177S|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.Y177S|IL12RB2_uc010oqm.1_Missense_Mutation_p.Y177S|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	177	Extracellular (Potential).|Fibronectin type-III 1.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						AAAGACATTTATTGTGACTAT	0.398													56	70					0	0	0	0	C	67793933	C	C	67793933	3	2	19	1	0	0	0	0	1	0	0	0	7666	449	16	5	544	5	IL12RB2	1	67793933	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	1729538	67793933	181456688	4	4202											
MSH4	4438	broad.mit.edu	37	chr1	76272747	76272747	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaggacttgccagaggtgAaataggaatggcaagtattg	14	8	15	4	0	0	3	0	1	0	2	0	6	0	5	1	4	1	2	1	4	5	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:76272747A>G	uc001dhd.1	+	3	550	c.509A>G	c.(508-510)GAA>GGA	p.E170G		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	170					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						GCCAGAGGTGAAATAGGAATG	0.363								MMR					19	52					0	0	0	0	G	76272747	G	G	76272747	3	3	19	1	0	0	0	0	1	0	0	0	9925	246	9	5	519	5	MSH4	1	76272747	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	8478814	76272747	172977874	5	4203											
LPHN2	23266	broad.mit.edu	37	chr1	82415915	82415915	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacttcttcagctgagctgtTcaaaaccataatatcaacca	15	11	4	11	0	4	1	3	1	1	0	4	1	4	1	2	0	5	3	2	0	6	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:82415915T>G	uc001dit.3	+	7	1422	c.1241T>G	c.(1240-1242)TTC>TGC	p.F414C	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.F414C|LPHN2_uc001div.2_Missense_Mutation_p.F414C|LPHN2_uc009wcd.2_Missense_Mutation_p.F414C|LPHN2_uc001diw.2_5'UTR	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	414	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GCTGAGCTGTTCAAAACCATA	0.428													43	135					0	0	0	0	G	82415915	G	G	82415915	3	3	19	1	0	0	0	0	1	0	0	0	8966	1783	62	5	1259	5	LPHN2	1	82415915	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	6143168	82415915	166834706	6	4204											
LPHN2	23266	broad.mit.edu	37	chr1	82416120	82416120	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggataaagtggcctcagacAcaaaggggaatgatggttga	14	7	15	5	0	1	3	1	2	0	1	1	5	1	5	1	5	0	1	1	5	4	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:82416120A>T	uc001dit.3	+	7	1627	c.1446A>T	c.(1444-1446)ACA>ACT	p.T482T	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.T482T|LPHN2_uc001div.2_Silent_p.T482T|LPHN2_uc009wcd.2_Silent_p.T482T|LPHN2_uc001diw.2_Silent_p.T53T	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	482	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GGCCTCAGACACAAAGGGGAA	0.398													11	36					0	0	0	0	T	82416120	T	T	82416120	2	4	19	1	0	0	0	0	0	0	0	1	8966	146	6	5		5	LPHN2	1	82416120	Silent	SNP	A	TCGA-BA-6872-01A-11D-1870-08	205	82416120	166834501	7	4205											
SPRR1A	6698	broad.mit.edu	37	chr1	152957935	152957935	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgagccctgcccttcaacgGtcactccagcaccagcccag	8	6	8	19	1	2	1	2	1	0	0	3	1	3	1	5	1	5	1	5	1	1	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:152957935G>A	uc009wnu.1	+	2	307	c.229G>A	c.(229-231)GTC>ATC	p.V77I	SPRR1A_uc001faw.2_Missense_Mutation_p.V77I	NM_005987	NP_005978	P35321	SPR1A_HUMAN	small proline-rich protein 1A	77	6.|6 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity				0	Lung NSC(65;1.46e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCCTTCAACGGTCACTCCAGC	0.617													39	87					0	0	0	0	A	152957935	A	A	152957935	3	1	19	1	0	0	0	0	1	0	0	0	15161	1261	44	4	231	4	SPRR1A	1	152957935	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	70541815	152957935	96292686	8	4206											
CD1A	909	broad.mit.edu	37	chr1	158224916	158224916	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccatgtcacctggatcgcatCcttttacaaccattcctgga	9	12	6	14	1	1	0	1	0	0	0	4	2	3	2	5	2	2	1	5	2	2	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:158224916C>G	uc001frt.2	+	2	634	c.101C>G	c.(100-102)TCC>TGC	p.S34C		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	34	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TGGATCGCATCCTTTTACAAC	0.478													23	122					0	0	0	0	G	158224916	G	G	158224916	3	3	19	1	0	0	0	0	1	0	0	0	2989	855	30	2	107	2	CD1A	1	158224916	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	5266981	158224916	91025705	9	4207											
OR6N1	128372	broad.mit.edu	37	chr1	158735835	158735835	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacataggagcagaggatcAgcaggaaggtggctaggatc	13	5	16	7	0	1	1	1	0	0	1	2	5	1	5	0	6	2	4	0	6	3	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:158735835A>C	uc010piq.1	-	1	638	c.638T>G	c.(637-639)CTG>CGG	p.L213R		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GCAGAGGATCAGCAGGAAGGT	0.498													8	120					0	0	0	0	C	158735835	C	C	158735835	3	2	19	1	0	0	0	0	1	0	0	0	11260	188	7	5	303	5	OR6N1	1	158735835	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	510919	158735835	90514786	10	4208											
CASQ1	844	broad.mit.edu	37	chr1	160165806	160165806	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagattgtcaacttcgtggaGgagcacaggaggtggggacc	10	7	17	7	1	1	1	1	0	0	1	2	6	1	5	1	6	2	1	1	6	1	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:160165806G>A	uc010pja.1	+	6	1028	c.771G>A	c.(769-771)GAG>GAA	p.E257E		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	257						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACTTCGTGGAGGAGCACAGGA	0.552													10	73					0	0	0	0	A	160165806	A	A	160165806	2	1	19	1	0	0	0	0	0	0	0	1	2692	991	35	4		4	CASQ1	1	160165806	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1429971	160165806	89084815	11	4209											
RGS5	8490	broad.mit.edu	37	chr1	163122400	163122400	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctttgccttctcagccatCttggcaggggacttgatctt	5	15	10	11	0	3	1	1	1	3	0	4	2	3	2	2	3	3	2	2	3	0	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:163122400C>G	uc001gcn.2	-	4	571	c.324G>C	c.(322-324)AAG>AAC	p.K108N	RGS5_uc009wvb.2_RNA	NM_003617	NP_003608	O15539	RGS5_HUMAN	regulator of G-protein signalling 5	108	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity				0			LUSC - Lung squamous cell carcinoma(543;0.187)			TCTCAGCCATCTTGGCAGGGG	0.448													62	282					0	0	0	0	G	163122400	G	G	163122400	3	3	19	1	0	0	0	0	1	0	0	0	13373	912	32	2	229	2	RGS5	1	163122400	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	2956594	163122400	86128221	12	4210											
TBX19	9095	broad.mit.edu	37	chr1	168260618	168260618	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggatgaaagctcccatctccTtcagcaaagtgaagctgacc	12	8	9	12	0	2	3	1	3	1	0	4	4	3	4	3	1	3	3	3	1	3	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:168260618T>C	uc001gfl.2	+	2	475	c.424T>C	c.(424-426)TTC>CTC	p.F142L	TBX19_uc001gfj.3_Missense_Mutation_p.F73L	NM_005149	NP_005140	O60806	TBX19_HUMAN	T-box 19	142	T-box.				anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)					TCCCATCTCCTTCAGCAAAGT	0.622													34	175					0	0	0	0	C	168260618	C	C	168260618	3	2	19	1	0	0	0	0	1	0	0	0	15720	1609	56	5	430	5	TBX19	1	168260618	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	5138218	168260618	80990003	13	4211											
NUAK2	81788	broad.mit.edu	37	chr1	205272810	205272811	+	Missense_Mutation	DNP	TC	AT	AT																															agtccagctggtcaaaggacTcagaggacaggatgctgtcc																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:205272810_205272811TC>AT	uc001hce.2	-	7	1781_1782	c.1654_1655GA>AT	c.(1654-1656)GAG>ATG	p.E552M		NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	552					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GTCAAAGGACTCAGAGGACAGG	0.673													7	50					0	0	0	0	AT	205272811	AT	AT	205272810	3	1	19	1	0	0	0	0	1	0	0	0	10767	1551	54	5	235	5	NUAK2	1	205272810	Missense_Mutation	DNP	TC	TCGA-BA-6872-01A-11D-1870-08	37012192	205272810	43977811	14	4212											
PROX1	5629	broad.mit.edu	37	chr1	214170581	214170581	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaaaagaacagaagcgagagGagcgccgacagctgaaacag	18	1	14	8	3	0	4	0	1	0	3	0	8	0	5	1	1	5	1	1	1	5	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr1:214170581G>A	uc001hkh.2	+	2	975	c.703G>A	c.(703-705)GAG>AAG	p.E235K	PROX1_uc001hkg.1_Missense_Mutation_p.E235K	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	235					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GAAGCGAGAGGAGCGCCGACA	0.498													10	48					0	0	0	0	A	214170581	A	A	214170581	3	1	19	1	0	0	0	0	1	0	0	0	12622	1175	41	2	705	2	PROX1	1	214170581	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	8897771	214170581	35080040	15	4213											
UBXN2A	165324	broad.mit.edu	37	chr2	24194165	24194165	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtttgtgaaacaggatctGataatcaacctcttggtaat	12	13	10	6	0	3	2	1	2	2	0	3	3	3	3	1	3	2	2	1	3	4	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:24194165G>C	uc010exy.2	+	4	529	c.61G>C	c.(61-63)GAT>CAT	p.D21H	UBXN2A_uc002rem.2_RNA|UBXN2A_uc002ren.2_Missense_Mutation_p.D21H|UBXN2A_uc010ykj.1_Missense_Mutation_p.D21H	NM_181713	NP_859064	P68543	UBX2A_HUMAN	UBX domain containing 4	21											0						AACAGGATCTGATAATCAACC	0.313													8	102					0	0	0	0	C	24194165	C	C	24194165	3	2	19	1	0	0	0	0	1	0	0	0	16982	1290	45	2	67	2	UBXN2A	2	24194165	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08		24194165	219005208	16	4214											
FOSL2	2355	broad.mit.edu	37	chr2	28626989	28626989	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcagaaattccgggtagatAtgcctggctcaggcagtgca	10	10	12	9	1	2	2	2	0	0	2	3	2	3	2	2	3	2	4	2	3	3	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:28626989A>G	uc002rma.2	+	2	927	c.118A>G	c.(118-120)ATG>GTG	p.M40V	FOSL2_uc010ymi.1_Missense_Mutation_p.M1V	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	40					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					CCGGGTAGATATGCCTGGCTC	0.463													28	83					0	0	0	0	G	28626989	G	G	28626989	3	3	19	1	0	0	0	0	1	0	0	0	6020	449	16	5	124	5	FOSL2	2	28626989	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	4432824	28626989	214572384	17	4215											
RTN4	57142	broad.mit.edu	37	chr2	55252582	55252582	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcagtatattccctggctaAtttagaaaatgaatcagttt	13	15	7	6	0	2	2	2	1	0	1	3	2	3	2	1	1	0	3	1	1	7	7			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:55252582A>C	uc002rye.2	-	3	2951	c.2653T>G	c.(2653-2655)TTA>GTA	p.L885V	RTN4_uc002ryd.2_Missense_Mutation_p.L679V|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	885	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						TCCCTGGCTAATTTAGAAAAT	0.388													34	19					0	0	0	0	C	55252582	C	C	55252582	3	2	19	1	0	0	0	0	1	0	0	0	13793	98	4	5	991	5	RTN4	2	55252582	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	26625593	55252582	187946791	18	4216											
MCM6	4175	broad.mit.edu	37	chr2	136614422	136614422	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgattgggtttgctgctGccaaaatggacgtccgggcg	7	10	14	10	3	0	1	0	1	0	0	1	2	1	2	2	3	3	3	2	3	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:136614422G>T	uc002tuw.2	-	11	1578	c.1502C>A	c.(1501-1503)GCA>GAA	p.A501E		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	501	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	GTTTGCTGCTGCCAAAATGGA	0.338													16	31					0.000566183	0.000617889	1	0	T	136614422	T	T	136614422	3	4	19	1	0	0	0	0	1	0	0	0	9444	1319	46	4	991	4	MCM6	2	136614422	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	81361840	136614422	106584951	19	4217											
EPC2	26122	broad.mit.edu	37	chr2	149501231	149501231	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaccagattatgatatggaTtcagaagatgagactttatt	15	13	8	5	0	1	5	1	2	0	4	1	7	1	6	1	1	1	0	1	1	5	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:149501231T>G	uc010zbt.1	+	3	381	c.354T>G	c.(352-354)GAT>GAG	p.D118E		NM_015630	NP_056445	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2	118					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)		ATGATATGGATTCAGAAGATG	0.294													9	14					0	0	0	0	G	149501231	G	G	149501231	3	3	19	1	0	0	0	0	1	0	0	0	5185	1490	52	5	364	5	EPC2	2	149501231	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	12886809	149501231	93698142	20	4218											
KIF5C	3800	broad.mit.edu	37	chr2	149868127	149868127	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacccggcctcatctccaacGgccgtccatgccattcgagg	7	8	9	17	4	2	0	1	0	1	0	5	1	3	0	6	3	3	0	6	3	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:149868127G>A	uc010zbu.1	+	25	3179	c.2811G>A	c.(2809-2811)ACG>ACA	p.T937T	KIF5C_uc002tws.1_RNA|KIF5C_uc002twu.1_Silent_p.T219T	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	937	Globular.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		CATCTCCAACGGCCGTCCATG	0.498													18	45					0	0	0	0	A	149868127	A	A	149868127	2	1	19	1	0	0	0	0	0	0	0	1	8346	1103	39	1		1	KIF5C	2	149868127	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08	366896	149868127	93331246	21	4219											
SCN1A	6323	broad.mit.edu	37	chr2	166848067	166848067	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcgttttaaagtagtagtGattggctgataggagacctt	10	16	11	4	1	0	3	0	2	0	1	1	4	0	3	1	2	0	4	1	2	5	8			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:166848067G>A	uc010zcz.1	-	26	5703	c.5685C>T	c.(5683-5685)ATC>ATT	p.I1895I		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1906						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AAGTAGTAGTGATTGGCTGAT	0.443													11	118					0	0	0	0	A	166848067	A	A	166848067	2	1	19	1	0	0	0	0	0	0	0	1	13979	1280	45	2		2	SCN1A	2	166848067	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08	16979940	166848067	76351306	22	4220											
XIRP2	129446	broad.mit.edu	37	chr2	168101809	168101809	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagaaaacaattactgaaGaagtaatacagggtgatgta	19	8	9	5	0	0	4	0	2	0	2	0	4	0	4	1	1	3	2	1	1	10	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:168101809G>T	uc002udx.2	+	8	3925	c.3907G>T	c.(3907-3909)GAA>TAA	p.E1303*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.E1128*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.E1081*|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1128					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AATTACTGAAGAAGTAATACA	0.383													17	65					1.5739e-10	1.80847e-10	1	0	T	168101809	T	T	168101809	4	4	19	1	0	0	0	0	0	1	0	0	17498	943	33	2	3937	2	XIRP2	2	168101809	Nonsense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1253742	168101809	75097564	23	4221											
XIRP2	129446	broad.mit.edu	37	chr2	168105100	168105100	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaacaatattcccaaaaaGaagcctcgaactctcagaat	17	8	5	11	1	1	2	1	0	1	2	4	3	2	2	2	0	4	1	2	0	8	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:168105100G>A	uc002udx.2	+	8	7216	c.7198G>A	c.(7198-7200)GAA>AAA	p.E2400K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E2225K|XIRP2_uc010fpq.2_Missense_Mutation_p.E2178K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2225					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTCCCAAAAAGAAGCCTCGAA	0.473													4	102					0	0	0	0	A	168105100	A	A	168105100	3	1	19	1	0	0	0	0	1	0	0	0	17498	943	33	2	7228	2	XIRP2	2	168105100	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	3291	168105100	75094273	24	4222											
LRP2	4036	broad.mit.edu	37	chr2	170065990	170065990	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaatccactgcaataccccGgactccattttctcctattc	9	12	3	17	1	1	0	0	0	1	0	5	1	3	1	6	1	2	1	6	1	4	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:170065990G>A	uc002ues.2	-	38	6655	c.6442C>T	c.(6442-6444)CGG>TGG	p.R2148W		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2148	LDL-receptor class B 20.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GCAATACCCCGGACTCCATTT	0.398													19	124					0	0	0	0	A	170065990	A	A	170065990	3	1	19	1	0	0	0	0	1	0	0	0	9006	1115	39	1	7693	1	LRP2	2	170065990	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1960890	170065990	73133383	25	4223											
SCRN3	79634	broad.mit.edu	37	chr2	175292478	175292479	+	Frame_Shift_Del	DEL	TG	-	-																															gttggacaacatgaggaaacTggagaaagaactattcagag																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:175292478_175292479delTG	uc002uiq.2	+	8	1218_1219	c.1130_1131delTG	c.(1129-1131)CTGfs	p.L377fs	SCRN3_uc010zen.1_Frame_Shift_Del_p.L370fs|SCRN3_uc010zeo.1_Frame_Shift_Del_p.L175fs|SCRN3_uc002uis.2_Frame_Shift_Del_p.L119fs	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	377					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			ATGAGGAAACTGGAGAAAGAAC	0.297													---	---	---								-	175292479	-	-	175292478	7	5	19	1	0	1	0	1	0	0	0	0	14005	1580	55	0	1156	0	SCRN3	2	175292478	Frame_Shift_Del	DEL	TG	TCGA-BA-6872-01A-11D-1870-08	5226488	175292478	67906895	26	4224											
KIAA1715	80856	broad.mit.edu	37	chr2	176794907	176794907	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctctgtattatcatcaaGaacatcgtgttctaaagatt	12	15	6	8	1	4	2	2	0	2	2	5	2	4	2	0	0	2	3	0	0	6	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:176794907G>A	uc002ukc.1	-	13	1268	c.1075C>T	c.(1075-1077)CTT>TTT	p.L359F	KIAA1715_uc010zer.1_Missense_Mutation_p.L390F|KIAA1715_uc010fqw.1_Missense_Mutation_p.L425F|KIAA1715_uc010zes.1_Missense_Mutation_p.L361F|KIAA1715_uc002ukd.1_Missense_Mutation_p.L236F|KIAA1715_uc010zet.1_RNA	NM_030650	NP_085153	Q9C0E8	LNP_HUMAN	Lunapark	359	Cytoplasmic (Potential).					integral to membrane	protein binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0793)			TTATCATCAAGAACATCGTGT	0.343													4	167					0	0	0	0	A	176794907	A	A	176794907	3	1	19	1	0	0	0	0	1	0	0	0	8293	942	33	2	215	2	KIAA1715	2	176794907	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1502429	176794907	66404466	27	4225											
OSBPL6	114880	broad.mit.edu	37	chr2	179213991	179213991	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcaccagttcgcttgcattCctccaaccccaacctttgtg	7	12	6	16	1	1	0	1	0	0	0	4	0	3	0	6	0	3	3	6	0	2	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:179213991C>T	uc002ulx.2	+	12	1406	c.1028C>T	c.(1027-1029)TCC>TTC	p.S343F	OSBPL6_uc002ulw.2_Missense_Mutation_p.S312F|OSBPL6_uc002uly.2_Missense_Mutation_p.S368F|OSBPL6_uc010zfe.1_Missense_Mutation_p.S312F|OSBPL6_uc002ulz.2_Missense_Mutation_p.S343F|OSBPL6_uc002uma.2_Missense_Mutation_p.S347F	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	343					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CGCTTGCATTCCTCCAACCCC	0.438													17	271					0	0	0	0	T	179213991	T	T	179213991	3	4	19	1	0	0	0	0	1	0	0	0	11335	855	30	2	1188	2	OSBPL6	2	179213991	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	2419084	179213991	63985382	28	4226											
TTN	7273	broad.mit.edu	37	chr2	179403855	179403855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtcagtggatgtctctttgCgttcgatgtagtagcctgtg	5	16	13	7	2	2	0	1	0	1	0	4	2	2	1	1	1	2	3	1	1	2	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:179403855C>T	uc010zfg.1	-	302	91327	c.91103G>A	c.(91102-91104)CGC>CAC	p.R30368H	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R24063H|TTN_uc010zfi.1_Missense_Mutation_p.R23996H|TTN_uc010zfj.1_Missense_Mutation_p.R23871H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31295							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTCTCTTTGCGTTCGATGTA	0.498													16	114					0	0	0	0	T	179403855	T	T	179403855	3	4	19	1	0	0	0	0	1	0	0	0	16803	768	27	1	9212	1	TTN	2	179403855	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	189864	179403855	63795518	29	4227											
TTN	7273	broad.mit.edu	37	chr2	179544334	179544334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggtggtgtaccttttgccGgtggagcttccttcttcttg	3	17	12	9	1	2	0	0	0	2	0	3	1	3	1	3	4	3	2	3	4	1	7			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:179544334G>A	uc010zfg.1	-	138	30148	c.29924C>T	c.(29923-29925)CCG>CTG	p.P9975L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6636L|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10902							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTTTGCCGGTGGAGCTTC	0.418													8	31					0	0	0	0	A	179544334	A	A	179544334	3	1	19	1	0	0	0	0	1	0	0	0	16803	1116	39	1	70761	1	TTN	2	179544334	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	140479	179544334	63655039	30	4228											
NCKAP1	10787	broad.mit.edu	37	chr2	183850902	183850902	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaataaaactactcacgcaTgtgacacggctgcctccttg	13	9	7	12	2	1	1	1	1	0	0	2	1	2	1	2	1	3	2	2	1	5	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:183850902T>C	uc002upc.2	-	10	1403	c.1001A>G	c.(1000-1002)CAT>CGT	p.H334R	NCKAP1_uc002upb.2_Missense_Mutation_p.H340R	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	334					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TACTCACGCATGTGACACGGC	0.318													6	12					0	0	0	0	C	183850902	C	C	183850902	3	2	19	1	0	0	0	0	1	0	0	0	10275	1464	51	5	2473	5	NCKAP1	2	183850902	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	4306568	183850902	59348471	31	4229											
ERBB4	2066	broad.mit.edu	37	chr2	212488717	212488717	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctcagtttctttcaaaataCgaagttgagcttgattgggt	10	15	10	6	1	3	2	2	2	1	0	3	3	3	2	0	1	2	4	0	1	4	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:212488717C>A	uc002veg.1	-	18	2230	c.2132G>T	c.(2131-2133)CGT>CTT	p.R711L	ERBB4_uc002veh.1_Missense_Mutation_p.R711L|ERBB4_uc010zji.1_Missense_Mutation_p.R701L|ERBB4_uc010zjj.1_Missense_Mutation_p.R701L|ERBB4_uc010fut.1_Missense_Mutation_p.R711L	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	711	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TTTCAAAATACGAAGTTGAGC	0.418										TSP Lung(8;0.080)			4	57					0.00909568	0.0094516	1	0	A	212488717	A	A	212488717	3	1	19	1	0	0	0	0	1	0	0	0	5233	536	19	3	1838	3	ERBB4	2	212488717	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	28637815	212488717	30710656	32	4230											
ABCA12	26154	broad.mit.edu	37	chr2	215854110	215854110	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataaatgaaagagtcagctaGgattagacagcacagccagc	17	6	10	8	0	1	3	1	1	0	2	1	4	1	4	1	1	4	2	1	1	5	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:215854110G>T	uc002vew.2	-	26	3992	c.3772C>A	c.(3772-3774)CTA>ATA	p.L1258I	ABCA12_uc002vev.2_Missense_Mutation_p.L940I|ABCA12_uc010zjn.1_Missense_Mutation_p.L185I	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1258	Helical; (Potential).				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GAGTCAGCTAGGATTAGACAG	0.423													9	68					1.12685e-05	1.25264e-05	1	0	T	215854110	T	T	215854110	3	4	19	1	0	0	0	0	1	0	0	0	30	991	35	4	4127	4	ABCA12	2	215854110	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	3365393	215854110	27345263	33	4231											
TRIP12	9320	broad.mit.edu	37	chr2	230693917	230693917	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttttacttactagctccaCttccaattgttctatggaaa	11	17	4	9	0	1	0	0	0	1	0	3	1	3	1	2	1	3	2	2	1	6	9			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr2:230693917C>T	uc002vpw.1	-	7	1407	c.1298G>A	c.(1297-1299)AGT>AAT	p.S433N	TRIP12_uc002vpx.1_Missense_Mutation_p.S481N|TRIP12_uc002vpy.1_Missense_Mutation_p.S136N|TRIP12_uc010zlz.1_Intron|TRIP12_uc010fxh.1_Missense_Mutation_p.S439N	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	433					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		ACTAGCTCCACTTCCAATTGT	0.393													7	36					0	0	0	0	T	230693917	T	T	230693917	3	4	19	1	0	0	0	0	1	0	0	0	16623	565	20	4	4820	4	TRIP12	2	230693917	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	14839807	230693917	12505456	34	4232											
TRANK1	9881	broad.mit.edu	37	chr3	36873988	36873988	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttcagactctagagctttGagttccctgttgtagttgtc	6	18	9	8	0	2	3	1	1	1	2	4	3	3	3	1	0	1	5	1	0	2	8			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr3:36873988G>C	uc003cgj.2	-	12	5606	c.5304C>G	c.(5302-5304)CTC>CTG	p.L1768L		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2318	Potential.				DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CTAGAGCTTTGAGTTCCCTGT	0.512													7	75					0	0	0	0	C	36873988	C	C	36873988	2	2	19	1	0	0	0	0	0	0	0	1	16521	1277	45	2		2	TRANK1	3	36873988	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08		36873988	161148442	35	4233											
ULK4	54986	broad.mit.edu	37	chr3	41960008	41960008	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttcagttaattctgaaataCtttctgagaagaatggaggt	13	15	9	4	0	3	3	1	2	2	2	3	5	3	4	0	2	1	1	0	2	5	5	rs55840267		TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr3:41960008C>A	uc003ckv.3	-	7	869	c.668G>T	c.(667-669)AGT>ATT	p.S223I	ULK4_uc003ckw.2_Missense_Mutation_p.S223I|ULK4_uc003ckx.1_Missense_Mutation_p.S223I	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	223	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TTCTGAAATACTTTCTGAGAA	0.274													3	64					0.00909568	0.0094516	1	0	A	41960008	A	A	41960008	3	1	19	1	0	0	0	0	1	0	0	0	17046	565	20	4	3283	4	ULK4	3	41960008	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	5086020	41960008	156062422	36	4234											
NKTR	4820	broad.mit.edu	37	chr3	42680530	42680530	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacaaaacattcagcacgttGaagaaagtgttcccaatgga	16	9	8	8	1	1	2	1	1	0	1	2	3	2	3	1	1	3	3	1	1	6	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr3:42680530G>A	uc003clo.2	+	13	3481	c.3334G>A	c.(3334-3336)GAA>AAA	p.E1112K	NKTR_uc003clm.1_Missense_Mutation_p.E859K|NKTR_uc003clp.2_Missense_Mutation_p.E859K|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.E1002K|NKTR_uc003clr.1_Missense_Mutation_p.E859K|NKTR_uc003cls.2_Missense_Mutation_p.E812K	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1112					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TCAGCACGTTGAAGAAAGTGT	0.408													10	37					0	0	0	0	A	42680530	A	A	42680530	3	1	19	1	0	0	0	0	1	0	0	0	10502	1291	45	2	3380	2	NKTR	3	42680530	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	720522	42680530	155341900	37	4235											
PDE12	201626	broad.mit.edu	37	chr3	57542704	57542704	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccttttccgctggtataagGaagccaagcccggagcggcg	8	7	13	13	4	0	0	0	0	0	0	1	2	1	2	4	4	3	2	4	4	4	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr3:57542704G>A	uc003diw.3	+	1	724	c.598G>A	c.(598-600)GAA>AAA	p.E200K	PDE12_uc003div.2_Missense_Mutation_p.E200K	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	200							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		CTGGTATAAGGAAGCCAAGCC	0.607													24	51					0	0	0	0	A	57542704	A	A	57542704	3	1	19	1	0	0	0	0	1	0	0	0	11686	1175	41	2	600	2	PDE12	3	57542704	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	14862174	57542704	140479726	38	4236											
FAM55C	91775	broad.mit.edu	37	chr3	101520115	101520115	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtttcagccactttcatcGacagcagtggacagtttgtt	8	14	9	10	1	2	0	2	0	0	0	3	2	2	1	1	1	2	4	1	1	0	4	rs139375291		TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr3:101520115G>A	uc003dvn.2	+	5	767	c.130G>A	c.(130-132)GAC>AAC	p.D44N	FAM55C_uc010hpn.2_Missense_Mutation_p.D44N	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	44						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						CACTTTCATCGACAGCAGTGG	0.458													27	161					0	0	0	0	A	101520115	A	A	101520115	3	1	19	1	0	0	0	0	1	0	0	0	5618	1058	37	1	136	1	FAM55C	3	101520115	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	43977411	101520115	96502315	39	4237											
KALRN	8997	broad.mit.edu	37	chr3	124207131	124207131	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagtgtcccaaagaaagcCaatgatgccatgcatgtcag	13	8	9	11	0	2	2	2	1	0	1	3	2	3	2	3	0	3	1	3	0	3	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr3:124207131C>T	uc003ehg.2	+	29	4486	c.4359C>T	c.(4357-4359)GCC>GCT	p.A1453A	KALRN_uc010hrv.1_Silent_p.A1444A|KALRN_uc003ehf.1_Silent_p.A1453A|KALRN_uc011bjy.1_Silent_p.A1444A|KALRN_uc003ehh.1_Silent_p.A799A	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1453	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CAAAGAAAGCCAATGATGCCA	0.532													4	91					0	0	0	0	T	124207131	T	T	124207131	2	4	19	1	0	0	0	0	0	0	0	1	8014	581	21	4		4	KALRN	3	124207131	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	22687016	124207131	73815299	40	4238											
ACAD9	28976	broad.mit.edu	37	chr3	128625055	128625055	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagggactatccgtacgagcGcatactgcgtgacacccgca	11	6	11	13	5	0	1	0	1	0	0	1	3	1	2	2	1	4	3	2	1	4	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr3:128625055G>A	uc003ela.3	+	12	1443	c.1241G>A	c.(1240-1242)CGC>CAC	p.R414H	ACAD9_uc010hsw.1_Missense_Mutation_p.R291H|ACAD9_uc011bks.1_Missense_Mutation_p.R291H|ACAD9_uc003elb.2_Missense_Mutation_p.R291H|ACAD9_uc003eld.1_RNA|ACAD9_uc003ele.2_Missense_Mutation_p.R66H	NM_014049	NP_054768	Q9H845	ACAD9_HUMAN	acyl-Coenzyme A dehydrogenase family, member 9	414						mitochondrion	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			ovary(2)|central_nervous_system(1)	3						CCGTACGAGCGCATACTGCGT	0.632													4	115					0	0	0	0	A	128625055	A	A	128625055	3	1	19	1	0	0	0	0	1	0	0	0	111	1087	38	1	1287	1	ACAD9	3	128625055	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	4417924	128625055	69397375	41	4239											
ZBTB38	253461	broad.mit.edu	37	chr3	141161426	141161426	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaatatcttttggagccatAcaatctgtatttccagccac	13	13	5	10	0	2	0	0	0	2	0	3	1	3	1	3	1	3	1	3	1	6	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr3:141161426A>G	uc003etw.2	+	8	1178	c.196A>G	c.(196-198)ACA>GCA	p.T66A	ZBTB38_uc010hun.2_Missense_Mutation_p.T63A|ZBTB38_uc010huo.2_Missense_Mutation_p.T66A|ZBTB38_uc003ety.2_Missense_Mutation_p.T66A|ZBTB38_uc010hup.2_Missense_Mutation_p.T67A	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	66	BTB.				positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TTGGAGCCATACAATCTGTAT	0.388													16	81					0	0	0	0	G	141161426	G	G	141161426	3	3	19	1	0	0	0	0	1	0	0	0	17606	391	14	5	198	5	ZBTB38	3	141161426	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	12536371	141161426	56861004	42	4240											
DVL3	1857	broad.mit.edu	37	chr3	183885832	183885832	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccgagcagtgctactacAtcttcggtgacctctgcggc	6	11	10	14	3	3	1	0	1	3	0	5	2	3	1	2	2	5	2	2	2	2	3	rs61758454		TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr3:183885832A>G	uc003fms.2	+	13	1617	c.1477A>G	c.(1477-1479)ATC>GTC	p.I493V	DVL3_uc011bqw.1_Missense_Mutation_p.I476V|DVL3_uc003fmt.2_Missense_Mutation_p.I164V|DVL3_uc003fmu.2_Missense_Mutation_p.I325V	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	493	DEP.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			GTGCTACTACATCTTCGGTGA	0.592													16	102					0	0	0	0	G	183885832	G	G	183885832	3	3	19	1	0	0	0	0	1	0	0	0	4859	217	8	5	1527	5	DVL3	3	183885832	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	42724406	183885832	14136598	43	4241											
CC2D2A	57545	broad.mit.edu	37	chr4	15589466	15589468	+	In_Frame_Del	DEL	GAA	-	-																															ttgatctcctggcaggggatGaagaagaacatgcagtacta																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr4:15589466_15589468delGAA	uc010idv.2	+	33	4338_4340	c.4093_4095delGAA	c.(4093-4095)GAAdel	p.E1367del	CC2D2A_uc003gnx.2_In_Frame_Del_p.E1259del|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	1367					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						GGCAGGGGATGAAGAAGAACATG	0.399													---	---	---								-	15589468	-	-	15589466	7	5	19	1	0	1	0	1	0	0	0	0	2740	1291	45	0	4418	0	CC2D2A	4	15589466	In_Frame_Del	DEL	GAA	TCGA-BA-6872-01A-11D-1870-08		15589466	175564810	44	4242											
GC	2638	broad.mit.edu	37	chr4	72635073	72635073	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgaagtcctcctttcccaGatgggagaattccttgcaga	9	12	10	10	0	0	4	0	1	0	3	4	5	4	4	4	1	1	1	4	1	2	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr4:72635073G>A	uc003hge.2	-	2	256	c.103C>T	c.(103-105)CTG>TTG	p.L35L	GC_uc003hgd.2_5'UTR|GC_uc010iie.2_Silent_p.L35L|GC_uc010iif.2_Silent_p.L54L	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	35	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TCCTTTCCCAGATGGGAGAAT	0.408													3	27					0	0	0	0	A	72635073	A	A	72635073	2	1	19	1	0	0	0	0	0	0	0	1	6317	933	33	2		2	GC	4	72635073	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08	57045607	72635073	118519203	45	4243											
ALB	213	broad.mit.edu	37	chr4	74274375	74274375	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaacctatggtgaaatggCtgactgctgtgcaaaacaag	14	9	11	7	0	0	3	0	3	0	0	0	3	0	3	1	2	4	3	1	2	6	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr4:74274375C>T	uc003hgs.3	+	4	408	c.335C>T	c.(334-336)GCT>GTT	p.A112V	ALB_uc003hgw.3_Intron|ALB_uc011cbe.1_Intron|ALB_uc003hgt.3_Missense_Mutation_p.A112V|ALB_uc010iii.2_Intron|ALB_uc003hgu.3_Intron|ALB_uc003hgv.3_Intron|ALB_uc011cbf.1_Missense_Mutation_p.A2V|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'Flank	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	112	Albumin 1.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	GGTGAAATGGCTGACTGCTGT	0.443													6	27					0	0	0	0	T	74274375	T	T	74274375	3	4	19	1	0	0	0	0	1	0	0	0	486	797	28	4	349	4	ALB	4	74274375	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	1639302	74274375	116879901	46	4244											
STBD1	8987	broad.mit.edu	37	chr4	77231134	77231134	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggataaagtggttcacgCatggtgggggattcactgat	10	11	15	5	1	2	2	2	2	0	0	2	4	2	4	0	5	0	2	0	5	2	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr4:77231134C>A	uc003hka.2	+	2	1304	c.1058C>A	c.(1057-1059)GCA>GAA	p.A353E	STBD1_uc003hjy.2_3'UTR|STBD1_uc011cbv.1_3'UTR|STBD1_uc011cbw.1_Missense_Mutation_p.A204E	NM_003943	NP_003934	O95210	STBD1_HUMAN	starch binding domain 1	353	CBM20.|Cytoplasmic (Potential).				carbohydrate metabolic process|muscle contraction	integral to plasma membrane|membrane fraction	carbohydrate binding|catalytic activity|protein binding			ovary(1)	1			Lung(101;0.196)			GTGGTTCACGCATGGTGGGGG	0.453													23	115					4.87955e-14	5.68885e-14	1	0	A	77231134	A	A	77231134	3	1	19	1	0	0	0	0	1	0	0	0	15340	710	25	4	1064	4	STBD1	4	77231134	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	2956759	77231134	113923142	47	4245											
HERC3	8916	broad.mit.edu	37	chr4	89627912	89627912	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctccccagtgttcctgaCaggcagcgatcggattccca	7	10	10	14	2	1	1	0	1	1	0	5	3	3	2	4	2	1	3	4	2	0	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr4:89627912C>A	uc003hrw.1	+	26	3120	c.2954C>A	c.(2953-2955)ACA>AAA	p.T985K	HERC3_uc011cdn.1_Missense_Mutation_p.T867K|HERC3_uc011cdo.1_Missense_Mutation_p.T429K	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	985	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		GTGTTCCTGACAGGCAGCGAT	0.552											OREG0016265	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	15					0.00024832	0.000272241	1	0	A	89627912	A	A	89627912	3	1	19	1	0	0	0	0	1	0	0	0	7098	478	17	4	3048	4	HERC3	4	89627912	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	12396778	89627912	101526364	48	4246											
INTS12	57117	broad.mit.edu	37	chr4	106604428	106604428	+	Frame_Shift_Del	DEL	G	-	-																															ttaagccactagttactgacGaggaaacgctggcactagaa																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr4:106604428delG	uc003hxw.2	-	8	1109	c.851delC	c.(850-852)TCGfs	p.S284fs	INTS12_uc010ilr.2_Frame_Shift_Del_p.S284fs	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	284	Ser-rich.				snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		AGTTACTGACGAGGAAACGCT	0.378													---	---	---								-	106604428	-	-	106604428	7	5	19	1	0	1	0	1	0	0	0	0	7816	1059	37	0	541	0	INTS12	4	106604428	Frame_Shift_Del	DEL	G	TCGA-BA-6872-01A-11D-1870-08	16976516	106604428	84549848	49	4247											
CCDC110	256309	broad.mit.edu	37	chr4	186380147	186380147	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgttgcttctctaaagaaaGttgtatatttttttcctcta	9	21	5	6	0	2	1	0	0	2	1	4	1	3	1	1	0	1	4	1	0	6	11			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr4:186380147G>C	uc003ixu.3	-	6	1670	c.1594C>G	c.(1594-1596)CTT>GTT	p.L532V	CCDC110_uc003ixv.3_Missense_Mutation_p.L495V|CCDC110_uc011ckt.1_Missense_Mutation_p.L532V	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	532	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TCTAAAGAAAGTTGTATATTT	0.264													13	31					0	0	0	0	C	186380147	C	C	186380147	3	2	19	1	0	0	0	0	1	0	0	0	2759	1029	36	4	915	4	CCDC110	4	186380147	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	79775719	186380147	4774129	50	4248											
DNAH5	1767	broad.mit.edu	37	chr5	13901525	13901525	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctatggaagagctggcgggCccacaaaatctttccagcga	11	7	11	12	2	1	1	0	0	1	1	2	3	2	2	3	3	2	1	3	3	4	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:13901525C>T	uc003jfd.2	-	14	1930	c.1888G>A	c.(1888-1890)GCC>ACC	p.A630T		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	630	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGCTGGCGGGCCCACAAAATC	0.502									Kartagener_syndrome				7	30					0	0	0	0	T	13901525	T	T	13901525	3	4	19	1	0	0	0	0	1	0	0	0	4626	739	26	4	12250	4	DNAH5	5	13901525	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08		13901525	167013735	51	4249											
SEMA6A	57556	broad.mit.edu	37	chr5	115782551	115782551	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctcccctgccaaagctctGgtttctggagaggtgagagg	7	10	14	10	0	3	2	0	1	3	2	4	4	3	2	3	4	2	2	3	4	1	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:115782551G>T	uc010jck.2	-	19	3560	c.2851C>A	c.(2851-2853)CAG>AAG	p.Q951K	SEMA6A_uc003krx.3_Missense_Mutation_p.Q968K|SEMA6A_uc011cwe.1_Missense_Mutation_p.Q330K|SEMA6A_uc003krv.3_Missense_Mutation_p.Q378K|SEMA6A_uc003krw.3_Missense_Mutation_p.Q428K|SEMA6A_uc010jcj.2_Missense_Mutation_p.Q495K	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	951	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CCAAAGCTCTGGTTTCTGGAG	0.607													10	38					1.76689e-08	2.00136e-08	1	0	T	115782551	T	T	115782551	3	4	19	1	0	0	0	0	1	0	0	0	14104	1357	47	4	245	4	SEMA6A	5	115782551	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	101881026	115782551	65132709	52	4250											
FTMT	94033	broad.mit.edu	37	chr5	121188162	121188162	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgctctactcttggaaaaGaacgtgaaccagtcgttgct	10	12	10	9	2	2	2	0	1	2	1	3	3	2	3	1	1	5	3	1	1	5	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:121188162G>C	uc003kss.2	+	1	513	c.504G>C	c.(502-504)AAG>AAC	p.K168N		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	168	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		TCTTGGAAAAGAACGTGAACC	0.547													17	91					0	0	0	0	C	121188162	C	C	121188162	3	2	19	1	0	0	0	0	1	0	0	0	6119	933	33	2	506	2	FTMT	5	121188162	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	5405611	121188162	59727098	53	4251											
HSPA4	3308	broad.mit.edu	37	chr5	132440096	132440096	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctgtgccttcggattcaGacaagaagcttcctgaaatg	11	10	10	10	1	1	3	1	1	0	2	3	4	2	4	2	1	3	2	2	1	3	3	rs144576995		TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:132440096G>T	uc003kyj.2	+	19	2772	c.2491G>T	c.(2491-2493)GAC>TAC	p.D831Y		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	831					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTCGGATTCAGACAAGAAGCT	0.423													14	64					6.72482e-11	7.76441e-11	1	0	T	132440096	T	T	132440096	3	4	19	1	0	0	0	0	1	0	0	0	7451	942	33	2	2565	2	HSPA4	5	132440096	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	11251934	132440096	48475164	54	4252											
CD14	929	broad.mit.edu	37	chr5	140012362	140012362	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgcatcgacgcgctttagAaacggctctaggttgagacc	9	9	11	12	5	1	2	0	1	1	2	3	4	2	2	2	2	1	4	2	2	3	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:140012362A>T	uc003lgi.1	-	2	561	c.207T>A	c.(205-207)TTT>TTA	p.F69L	CD14_uc003lgj.1_Missense_Mutation_p.F69L	NM_000591	NP_000582	P08571	CD14_HUMAN	CD14 antigen precursor	69	LRR 1.				apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCTTTAGAAACGGCTCTA	0.632													4	38					0	0	0	0	T	140012362	T	T	140012362	3	4	19	1	0	0	0	0	1	0	0	0	2979	243	9	5	924	5	CD14	5	140012362	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	7572266	140012362	40902898	55	4253											
PCDHA3	56145	broad.mit.edu	37	chr5	140181796	140181796	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gatcactgcacagttctactCgaaattgtggacatcaatga	13	11	8	9	1	3	1	2	1	1	0	4	4	3	2	0	1	2	2	0	1	3	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:140181796C>G	uc003lhf.2	+	1	1014	c.1014C>G	c.(1012-1014)CTC>CTG	p.L338L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.L338L	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	338	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTTCTACTCGAAATTGTGG	0.398													3	71					0	0	0	0	G	140181796	G	G	140181796	2	3	19	1	0	0	0	0	0	0	0	1	11579	871	31	3		3	PCDHA3	5	140181796	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	169434	140181796	40733464	56	4254											
RNF14	9604	broad.mit.edu	37	chr5	141363007	141363007	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggctaataaaagacttttgGatcaaaggtatggtaagaga	17	10	11	3	0	1	2	1	0	0	2	1	4	1	3	0	4	0	3	0	4	6	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:141363007G>T	uc003lly.2	+	6	1165	c.1126G>T	c.(1126-1128)GAT>TAT	p.D376Y	RNF14_uc003llz.2_Missense_Mutation_p.D376Y|RNF14_uc003lma.2_Missense_Mutation_p.D376Y|RNF14_uc003lmb.2_Missense_Mutation_p.D250Y|RNF14_uc003lmc.2_Missense_Mutation_p.D376Y|RNF14_uc011dbg.1_Missense_Mutation_p.D200Y|RNF14_uc011dbh.1_Missense_Mutation_p.D73Y|RNF14_uc003lmd.2_Missense_Mutation_p.D376Y	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	376	Potential.|Interaction with androgen receptor.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		AAGACTTTTGGATCAAAGGTA	0.378													3	22					0.004672	0.00494074	1	0	T	141363007	T	T	141363007	3	4	19	1	0	0	0	0	1	0	0	0	13508	1174	41	2	1144	2	RNF14	5	141363007	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1181211	141363007	39552253	57	4255											
PPARGC1B	133522	broad.mit.edu	37	chr5	149215963	149215963	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctcactcaaggccaccccaGgggctgcccacaagctgcca	9	5	9	18	0	2	0	2	0	1	0	3	0	2	0	5	3	3	2	5	3	2	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:149215963G>A	uc003lrc.2	+	8	1987	c.1945G>A	c.(1945-1947)GGG>AGG	p.G649R	PPARGC1B_uc003lrb.1_Missense_Mutation_p.G649R|PPARGC1B_uc003lrd.2_Missense_Mutation_p.G610R|PPARGC1B_uc003lrf.2_Missense_Mutation_p.G628R|PPARGC1B_uc003lre.1_Missense_Mutation_p.G628R	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	649					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GGCCACCCCAGGGGCTGCCCA	0.602													16	78					0	0	0	0	A	149215963	A	A	149215963	3	1	19	1	0	0	0	0	1	0	0	0	12356	1000	35	4	1982	4	PPARGC1B	5	149215963	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	7852956	149215963	31699297	58	4256											
C5orf54	63920	broad.mit.edu	37	chr5	159821116	159821116	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taagatctccaatggaaaaaTatccatggaagaagttgctc	16	10	8	7	0	1	2	0	0	1	2	4	4	2	4	2	2	1	2	2	2	7	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:159821116T>C	uc003lye.1	-	2	1846	c.1382A>G	c.(1381-1383)TAT>TGT	p.Y461C	C5orf54_uc003lyf.1_Missense_Mutation_p.Y461C	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	461										pancreas(1)	1						aatggaaaaatatccatggaa	0													8	62					0	0	0	0	C	159821116	C	C	159821116	3	2	19	1	0	0	0	0	1	0	0	0	2320	1406	49	5	406	5	C5orf54	5	159821116	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	10605153	159821116	21094144	59	4257											
CCNG1	900	broad.mit.edu	37	chr5	162866483	162866483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttgacacagagacattttCtctagctgtgaatttactgg	10	15	8	8	0	1	3	0	2	1	1	2	4	1	3	0	1	2	1	0	1	3	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:162866483C>T	uc003lzb.2	+	3	355	c.221C>T	c.(220-222)TCT>TTT	p.S74F	CCNG1_uc011dek.1_Intron|CCNG1_uc011del.1_Intron|CCNG1_uc003lzc.2_RNA	NM_199246	NP_954854	P51959	CCNG1_HUMAN	cyclin G1	74					cell division|mitosis|regulation of cyclin-dependent protein kinase activity	nucleus				lung(1)|kidney(1)	2	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0597)|OV - Ovarian serous cystadenocarcinoma(192;0.107)|Epithelial(171;0.164)		GAGACATTTTCTCTAGCTGTG	0.373													24	24					0	0	0	0	T	162866483	T	T	162866483	3	4	19	1	0	0	0	0	1	0	0	0	2938	913	32	2	223	2	CCNG1	5	162866483	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	3045367	162866483	18048777	60	4258											
FOXI1	2299	broad.mit.edu	37	chr5	169535531	169535531	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctcagctatggaggatcTgtgctcagccaattcagccc	9	10	10	12	0	4	0	3	0	1	0	4	2	4	2	2	2	5	3	2	2	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr5:169535531T>A	uc003mai.3	+	2	1098	c.1053T>A	c.(1051-1053)TCT>TCA	p.S351S	FOXI1_uc003maj.3_Silent_p.S256S	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	351					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATGGAGGATCTGTGCTCAGCC	0.582									Pendred_syndrome				10	62					0	0	0	0	A	169535531	A	A	169535531	2	1	19	1	0	0	0	0	0	0	0	1	6043	1567	55	5		5	FOXI1	5	169535531	Silent	SNP	T	TCGA-BA-6872-01A-11D-1870-08	6669048	169535531	11379729	61	4259											
TRIM10	10107	broad.mit.edu	37	chr6	30122152	30122152	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacaggtggcccggtcaaaaCgttgggggttgtctggtgag	7	9	17	8	2	2	1	1	1	1	0	2	1	2	1	1	6	1	2	1	6	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr6:30122152C>T	uc003npo.3	-	7	1116	c.1040G>A	c.(1039-1041)CGT>CAT	p.R347H	TRIM10_uc003npn.2_Missense_Mutation_p.R347H	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	347	B30.2/SPRY.					cytoplasm	zinc ion binding				0						CCGGTCAAAACGTTGGGGGTT	0.602													15	48					0	0	0	0	T	30122152	T	T	30122152	3	4	19	1	0	0	0	0	1	0	0	0	16553	536	19	1	497	1	TRIM10	6	30122152	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08		30122152	140992915	62	4260											
MTCH1	23787	broad.mit.edu	37	chr6	36936732	36936732	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcggaaaagcaggctggAgcctcggaagagctggccct	9	4	16	12	3	0	1	0	0	0	1	1	4	0	4	3	6	3	3	3	6	3	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr6:36936732A>G	uc003ond.1	-	12	1117	c.1117T>C	c.(1117-1119)TCC>CCC	p.S373P	MTCH1_uc003onc.1_Missense_Mutation_p.S356P|MTCH1_uc010jwo.1_RNA	NM_014341	NP_055156	Q9NZJ7	MTCH1_HUMAN	mitochondrial carrier homolog 1	373					activation of caspase activity|neuronal ion channel clustering|positive regulation of apoptosis|regulation of signal transduction|transport	integral to membrane|mitochondrial inner membrane	protein binding				0						AGCAGGCTGGAGCCTCGGAAG	0.562													3	63					0	0	0	0	G	36936732	G	G	36936732	3	3	19	1	0	0	0	0	1	0	0	0	9966	304	11	5	56	5	MTCH1	6	36936732	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	6814580	36936732	134178335	63	4261											
DST	667	broad.mit.edu	37	chr6	56417926	56417926	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgtgttgttcagtaattctaCcataccaaagtgttggtcca	10	15	8	8	0	2	0	1	0	1	0	3	0	3	0	3	1	2	4	3	1	4	7			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr6:56417926C>A	uc003pdf.2	-	55	9335	c.9307G>T	c.(9307-9309)GTA>TTA	p.V3103L	DST_uc003pcz.3_Missense_Mutation_p.V2925L|DST_uc011dxj.1_Missense_Mutation_p.V2954L|DST_uc011dxk.1_Missense_Mutation_p.V2965L|DST_uc003pcy.3_Missense_Mutation_p.V2599L	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5011					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGTAATTCTACCATACCAAAG	0.403													86	204					4.25105e-50	5.05473e-50	1	0	A	56417926	A	A	56417926	3	1	19	1	0	0	0	0	1	0	0	0	4805	507	18	4	7892	4	DST	6	56417926	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	19481194	56417926	114697141	64	4262											
PRIM2	5558	broad.mit.edu	37	chr6	57472427	57472427	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtcatacaagatctctcctGgagggataagccaggtaggt	12	9	12	8	0	2	1	1	0	1	1	4	3	3	3	2	4	2	1	2	4	4	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr6:57472427G>T	uc003pdx.2	+	13	1303	c.1216G>T	c.(1216-1218)GGA>TGA	p.G406*		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	406					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		GATCTCTCCTGGAGGGATAAG	0.448													5	47					2.0095e-06	2.26542e-06	1	0	T	57472427	T	T	57472427	4	4	19	1	0	0	0	0	0	1	0	0	12553	1349	47	4	1258	4	PRIM2	6	57472427	Nonsense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1054501	57472427	113642640	65	4263											
TBX18	9096	broad.mit.edu	37	chr6	85472390	85472390	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggccgggccagggagcgCgccggagaccccttggggga	5	2	20	14	5	0	1	0	0	0	1	0	4	0	3	6	6	1	0	6	6	0	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr6:85472390C>G	uc003pkl.1	-	2	369	c.369G>C	c.(367-369)GCG>GCC	p.A123A	TBX18_uc010kbq.1_5'UTR	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	123					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		CCAGGGAGCGCGCCGGAGACC	0.697													7	35					0	0	0	0	G	85472390	G	G	85472390	2	3	19	1	0	0	0	0	0	0	0	1	15719	755	27	3		3	TBX18	6	85472390	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	27999963	85472390	85642677	66	4264											
RRAGD	58528	broad.mit.edu	37	chr6	90097057	90097057	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctcctgttccccggaagAtcatctcatagtcaaatgta	10	12	8	11	1	3	1	3	0	1	1	6	2	5	2	3	1	1	3	3	1	4	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr6:90097057A>T	uc003pnd.3	-	2	684	c.401T>A	c.(400-402)ATC>AAC	p.I134N	RRAGD_uc010kcc.2_Intron	NM_021244	NP_067067	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	134					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			ovary(2)|central_nervous_system(1)	3		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		TCCCCGGAAGATCATCTCATA	0.498													16	124					0	0	0	0	T	90097057	T	T	90097057	3	4	19	1	0	0	0	0	1	0	0	0	13740	333	12	5	825	5	RRAGD	6	90097057	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	4624667	90097057	81018010	67	4265											
GRM1	2911	broad.mit.edu	37	chr6	146351225	146351225	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttattcagccacaagcatcgAcctgagtgacaaaactttgt	13	11	7	10	1	1	2	1	2	0	0	2	3	1	2	2	0	3	1	2	0	4	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr6:146351225A>T	uc010khw.1	+	2	1042	c.572A>T	c.(571-573)GAC>GTC	p.D191V	GRM1_uc010khu.1_Missense_Mutation_p.D191V|GRM1_uc010khv.1_Missense_Mutation_p.D191V|GRM1_uc003qll.2_Missense_Mutation_p.D191V|GRM1_uc011edz.1_Missense_Mutation_p.D191V|GRM1_uc011eea.1_Missense_Mutation_p.D191V	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	191	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ACAAGCATCGACCTGAGTGAC	0.507													49	65					0	0	0	0	T	146351225	T	T	146351225	3	4	19	1	0	0	0	0	1	0	0	0	6835	275	10	5	574	5	GRM1	6	146351225	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	56254168	146351225	24763842	68	4266											
PLEKHG1	57480	broad.mit.edu	37	chr6	151054974	151054974	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataaggaggtaggggccataAaactggagctgattcctgcc	12	8	13	8	0	0	1	0	1	0	0	1	3	1	3	3	5	3	2	3	5	4	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr6:151054974A>C	uc003qny.1	+	3	469	c.157A>C	c.(157-159)AAA>CAA	p.K53Q	PLEKHG1_uc011eel.1_Missense_Mutation_p.K93Q|PLEKHG1_uc011eem.1_Missense_Mutation_p.K112Q|PLEKHG1_uc003qnz.2_Missense_Mutation_p.K53Q	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	53					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		AGGGGCCATAAAACTGGAGCT	0.572													18	55					0	0	0	0	C	151054974	C	C	151054974	3	2	19	1	0	0	0	0	1	0	0	0	12123	15	1	5	159	5	PLEKHG1	6	151054974	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	4703749	151054974	20060093	69	4267											
RMND1	55005	broad.mit.edu	37	chr6	151766876	151766876	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaacattagatgaccgattCttcggcactgatgtgctttt	9	16	8	8	2	1	3	0	2	1	1	2	4	1	3	1	1	2	2	1	1	2	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr6:151766876C>A	uc003qoi.2	-	2	251	c.71G>T	c.(70-72)AGA>ATA	p.R24I	RMND1_uc011eeq.1_5'Flank|RMND1_uc003qoj.2_Missense_Mutation_p.R24I|RMND1_uc011eer.1_Missense_Mutation_p.R24I	NM_017909	NP_060379	Q9NWS8	RMND1_HUMAN	required for meiotic nuclear division 1 homolog	24											0		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.146)	OV - Ovarian serous cystadenocarcinoma(155;6.8e-11)		ATGACCGATTCTTCGGCACTG	0.403													14	34					4.36969e-10	4.97312e-10	1	0	A	151766876	A	A	151766876	3	1	19	1	0	0	0	0	1	0	0	0	13461	913	32	2	1322	2	RMND1	6	151766876	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	711902	151766876	19348191	70	4268											
NUDT1	4521	broad.mit.edu	37	chr7	2290629	2290629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactccgcgaggtggacaCggtctagcgggagcccaggg	8	4	16	13	4	1	0	0	0	1	0	2	3	2	2	2	5	2	0	2	5	1	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr7:2290629C>T	uc003slp.1	+	5	635	c.533C>T	c.(532-534)ACG>ATG	p.T178M	NUDT1_uc003slq.1_Missense_Mutation_p.T155M|NUDT1_uc003slr.1_Missense_Mutation_p.T155M|NUDT1_uc003sls.1_Missense_Mutation_p.T178M|NUDT1_uc003slt.1_Missense_Mutation_p.T155M|NUDT1_uc003slu.1_Missense_Mutation_p.T178M|NUDT1_uc003slv.1_Missense_Mutation_p.T155M	NM_198949	NP_945187	P36639	8ODP_HUMAN	nudix-type motif 1 isoform p22	196					DNA protection|DNA repair|response to oxidative stress	cytoplasm	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|GTPase activity|metal ion binding|protein binding				0		Ovarian(82;0.0253)|Melanoma(862;0.155)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.8e-14)|BRCA - Breast invasive adenocarcinoma(126;0.15)		GAGGTGGACACGGTCTAGCGG	0.602								Direct_reversal_of_damage|Modulation_of_nucleotide_pools					18	140					0	0	0	0	T	2290629	T	T	2290629	3	4	19	1	0	0	0	0	1	0	0	0	10779	536	19	1	547	1	NUDT1	7	2290629	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08		2290629	156848034	71	4269											
C7orf10	79783	broad.mit.edu	37	chr7	40535977	40535977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatgaagaatgtatttgcaGaacctcaggtttgtttttga	12	15	9	5	0	1	4	1	2	0	2	1	4	1	4	1	1	2	4	1	1	4	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr7:40535977G>A	uc003thn.1	+	12	1126	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K	C7orf10_uc003thm.1_Missense_Mutation_p.E331K|C7orf10_uc003tho.1_Missense_Mutation_p.E313K	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	368							transferase activity			ovary(2)	2						TGTATTTGCAGAACCTCAGGT	0.403													4	27					0	0	0	0	A	40535977	A	A	40535977	3	1	19	1	0	0	0	0	1	0	0	0	2387	943	33	2	1037	2	C7orf10	7	40535977	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	38245348	40535977	118602686	72	4270											
EGFR	1956	broad.mit.edu	37	chr7	55218998	55218998	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatttcaggccaaaagtgtGatccaagctgtcccaatggg	12	9	10	10	0	1	1	1	1	0	0	3	1	3	1	3	2	1	1	3	2	4	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr7:55218998G>A	uc003tqk.2	+	5	817	c.571G>A	c.(571-573)GAT>AAT	p.D191N	EGFR_uc003tqh.2_Missense_Mutation_p.D191N|EGFR_uc003tqi.2_Missense_Mutation_p.D191N|EGFR_uc003tqj.2_Missense_Mutation_p.D191N|EGFR_uc010kzg.1_Missense_Mutation_p.D146N|EGFR_uc011kco.1_Missense_Mutation_p.D138N|EGFR_uc003tql.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	191	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCAAAAGTGTGATCCAAGCTG	0.498		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			59	724					0	0	0	0	A	55218998	A	A	55218998	3	1	19	1	0	0	0	0	1	0	0	0	4989	1290	45	2	589	2	EGFR	7	55218998	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	14683021	55218998	103919665	73	4271											
AASS	10157	broad.mit.edu	37	chr7	121738533	121738533	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatcctgttttgccaccaaGaagcccagcttctcttcttg	8	13	7	13	0	2	2	0	0	2	2	4	2	3	2	4	0	3	2	4	0	2	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr7:121738533G>A	uc003vka.2	-	14	1722	c.1626C>T	c.(1624-1626)TTC>TTT	p.F542F	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Silent_p.F542F|AASS_uc011knw.1_Silent_p.F30F	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	542	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	TTGCCACCAAGAAGCCCAGCT	0.338													13	48					0	0	0	0	A	121738533	A	A	121738533	2	1	19	1	0	0	0	0	0	0	0	1	24	933	33	2		2	AASS	7	121738533	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08	66519535	121738533	37400130	74	4272											
KIAA1549	57670	broad.mit.edu	37	chr7	138524925	138524926	+	Missense_Mutation	DNP	GC	TT	TT																															cccgtacgaaggccagcctgGccccccatactggctgcctc																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr7:138524925_138524926GC>TT	uc011kql.1	-	19	5599_5600	c.5550_5551GC>AA	c.(5548-5553)GGGCCA>GGAACA	p.P1851T	KIAA1549_uc011kqi.1_Missense_Mutation_p.P635T|KIAA1549_uc003vuk.3_Missense_Mutation_p.P1801T|KIAA1549_uc011kqj.1_Missense_Mutation_p.P1851T|KIAA1549_uc011kqk.1_Missense_Mutation_p.P635T	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1851						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GGCCAGCCTGGCCCCCCATACT	0.545			O	BRAF	pilocytic astrocytoma								3	3					0	0	0	0	TT	138524926	TT	TT	138524925	3	4	19	1	0	0	0	0	1	0	0	0	8283	1203	42	4	309	4	KIAA1549	7	138524925	Missense_Mutation	DNP	GC	TCGA-BA-6872-01A-11D-1870-08	16786392	138524925	20613738	75	4273											
CLCN1	1180	broad.mit.edu	37	chr7	143020479	143020479	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgttctgcggggtatatgaGgtaaggttgagacagtgaaa	11	11	16	3	1	1	3	0	3	1	1	1	4	1	3	0	4	1	4	0	4	4	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr7:143020479G>C	uc003wcr.1	+	6	861	c.774G>C	c.(772-774)GAG>GAC	p.E258D	CLCN1_uc011ktc.1_5'UTR|CLCN1_uc003wcs.1_RNA|CLCN1_uc010lox.1_Intron|CLCN1_uc010loy.1_Intron	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	258					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					GGGTATATGAGGTAAGGTTGA	0.602													16	63					0	0	0	0	C	143020479	C	C	143020479	3	2	19	1	0	0	0	0	1	0	0	0	3477	1014	35	4	796	4	CLCN1	7	143020479	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	4495554	143020479	16118184	76	4274											
ZNF746	155061	broad.mit.edu	37	chr7	149191396	149191396	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccgcctctgcagcagccCgtactcctgcagcagggtcc	6	6	11	18	2	1	0	0	0	1	0	3	0	3	0	5	1	7	5	5	1	1	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr7:149191396C>A	uc003wfw.2	-	2	494	c.223G>T	c.(223-225)GGG>TGG	p.G75W	ZNF746_uc010lpi.2_Missense_Mutation_p.G75W	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	75	Potential.				negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TGCAGCAGCCCGTACTCCTGC	0.652													4	166					0.00909568	0.0094516	1	0	A	149191396	A	A	149191396	3	1	19	1	0	0	0	0	1	0	0	0	18196	652	23	3	1738	3	ZNF746	7	149191396	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	6170917	149191396	9947267	77	4275											
EFHA2	286097	broad.mit.edu	37	chr8	16963031	16963031	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcatattcttttacgatatAcaaatgtggaaaatacatca	16	14	4	7	1	3	0	2	0	1	0	3	2	3	1	0	1	3	0	0	1	8	7			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr8:16963031A>G	uc003wxd.2	+	11	1237	c.1195A>G	c.(1195-1197)ACA>GCA	p.T399A		NM_181723	NP_859074	Q86XE3	EFHA2_HUMAN	EF-hand domain family, member A2	399						integral to membrane	calcium ion binding			skin(1)	1				Colorectal(111;0.0686)|COAD - Colon adenocarcinoma(73;0.239)		TTTACGATATACAAATGTGGA	0.303													4	19					0	0	0	0	G	16963031	G	G	16963031	3	3	19	1	0	0	0	0	1	0	0	0	4966	391	14	5	1237	5	EFHA2	8	16963031	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08		16963031	129400991	78	4276											
STC1	6781	broad.mit.edu	37	chr8	23702493	23702493	+	Frame_Shift_Del	DEL	G	-	-																															ttctccatcaggctgtctctGattgtgctgactgtgtcttc																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr8:23702493delG	uc003xdw.1	-	4	818	c.534delC	c.(532-534)ATCfs	p.I178fs		NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor	178					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GGCTGTCTCTGATTGTGCTGA	0.502													---	---	---								-	23702493	-	-	23702493	7	5	19	1	0	1	0	1	0	0	0	0	15341	1280	45	0	213	0	STC1	8	23702493	Frame_Shift_Del	DEL	G	TCGA-BA-6872-01A-11D-1870-08	6739462	23702493	122661529	79	4277											
ADAM2	2515	broad.mit.edu	37	chr8	39613286	39613286	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttccatcttttatccacatCttttggctgtctgcatgatc	6	18	6	11	0	3	1	0	1	3	0	6	1	5	1	2	1	1	3	2	1	1	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr8:39613286C>G	uc003xnj.2	-	16	1833	c.1758G>C	c.(1756-1758)AAG>AAC	p.K586N	ADAM2_uc003xnk.2_Missense_Mutation_p.K567N|ADAM2_uc011lck.1_Intron|ADAM2_uc003xnl.2_Missense_Mutation_p.K430N	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	586	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TTATCCACATCTTTTGGCTGT	0.338													25	10					0	0	0	0	G	39613286	G	G	39613286	3	3	19	1	0	0	0	0	1	0	0	0	241	912	32	2	469	2	ADAM2	8	39613286	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	15910793	39613286	106750736	80	4278											
POTEA	340441	broad.mit.edu	37	chr8	43147924	43147924	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaaaagggacaagaagaaGaggtaaccgggcctggggct	16	3	15	7	1	0	3	0	0	0	3	0	4	0	4	2	5	2	2	2	5	7	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr8:43147924G>T	uc003xpz.1	+	1	340	c.297G>T	c.(295-297)AAG>AAT	p.K99N	POTEA_uc003xqa.1_Missense_Mutation_p.K99N	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	99	ANK 1.									ovary(1)	1						ACAAGAAGAAGAGGTAACCGG	0.627													9	23					0.000673444	0.000731605	1	0	T	43147924	T	T	43147924	3	4	19	1	0	0	0	0	1	0	0	0	12316	933	33	2	299	2	POTEA	8	43147924	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	3534638	43147924	103216098	81	4279											
ZFHX4	79776	broad.mit.edu	37	chr8	77763747	77763747	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agaaaagggcccaattttacGatggaaaaattccttgatcc	15	10	8	8	1	0	2	0	1	0	1	2	4	2	3	3	2	1	0	3	2	6	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr8:77763747G>C	uc003yav.2	+	10	4842	c.4455G>C	c.(4453-4455)ACG>ACC	p.T1485T	ZFHX4_uc003yau.1_Silent_p.T1530T|ZFHX4_uc003yaw.1_Silent_p.T1485T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1485						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAATTTTACGATGGAAAAAT	0.403										HNSCC(33;0.089)			4	45					0	0	0	0	C	77763747	C	C	77763747	2	2	19	1	0	0	0	0	0	0	0	1	17702	1045	37	3		3	ZFHX4	8	77763747	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08	34615823	77763747	68600275	82	4280											
MMP16	4325	broad.mit.edu	37	chr8	89128802	89128802	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcccatcacagatgttgggTttggctccgggataggaggg	7	11	15	8	1	1	1	1	0	0	1	3	3	3	3	2	5	0	3	2	5	1	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr8:89128802T>G	uc003yeb.3	-	6	1299	c.1017A>C	c.(1015-1017)AAA>AAC	p.K339N	MMP16_uc003yec.2_Missense_Mutation_p.K339N	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	339	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						AGATGTTGGGTTTGGCTCCGG	0.483													44	56					0	0	0	0	G	89128802	G	G	89128802	3	3	19	1	0	0	0	0	1	0	0	0	9708	1722	60	5	982	5	MMP16	8	89128802	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	11365055	89128802	57235220	83	4281											
CSMD3	114788	broad.mit.edu	37	chr8	113256689	113256689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactctatgttctgttccacCtgctaagaagaagccaggct	10	11	8	12	0	2	2	0	0	2	2	3	2	3	2	3	1	2	4	3	1	4	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr8:113256689C>T	uc003ynu.2	-	65	10495	c.10336G>A	c.(10336-10338)GGT>AGT	p.G3446S	CSMD3_uc003yns.2_Missense_Mutation_p.G2648S|CSMD3_uc003ynt.2_Missense_Mutation_p.G3406S|CSMD3_uc011lhx.1_Missense_Mutation_p.G3277S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3446	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCTGTTCCACCTGCTAAGAAG	0.428										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	59					0	0	0	0	T	113256689	T	T	113256689	3	4	19	1	0	0	0	0	1	0	0	0	3963	681	24	4	815	4	CSMD3	8	113256689	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	24127887	113256689	33107333	84	4282											
CSMD3	114788	broad.mit.edu	37	chr8	113317029	113317029	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggcaggacctagtccatgAtaaccagggtcacagctgaa	13	6	12	10	0	1	2	1	2	0	0	2	4	2	3	3	3	2	2	3	3	3	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr8:113317029A>G	uc003ynu.2	-	52	8346	c.8187T>C	c.(8185-8187)TAT>TAC	p.Y2729Y	CSMD3_uc003yns.2_Silent_p.Y1931Y|CSMD3_uc003ynt.2_Silent_p.Y2689Y|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2729	Extracellular (Potential).|Sushi 16.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTAGTCCATGATAACCAGGGT	0.408										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	47					0	0	0	0	G	113317029	G	G	113317029	2	3	19	1	0	0	0	0	0	0	0	1	3963	340	12	5		5	CSMD3	8	113317029	Silent	SNP	A	TCGA-BA-6872-01A-11D-1870-08	60340	113317029	33046993	85	4283											
TRMT12	55039	broad.mit.edu	37	chr8	125463385	125463385	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttccagagcagcacctgcagGagctgaggaatcgtgttgcc	9	8	13	11	1	0	2	0	1	0	1	2	4	1	4	3	2	5	5	3	2	1	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr8:125463385G>A	uc003yra.3	+	1	338	c.217G>A	c.(217-219)GAG>AAG	p.E73K		NM_017956	NP_060426	Q53H54	TYW2_HUMAN	homolog of yeast tRNA methyltransferase 12	73					tRNA processing		methyltransferase activity			upper_aerodigestive_tract(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GCACCTGCAGGAGCTGAGGAA	0.592													8	44					0	0	0	0	A	125463385	A	A	125463385	3	1	19	1	0	0	0	0	1	0	0	0	16631	1175	41	2	219	2	TRMT12	8	125463385	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	12146356	125463385	20900637	86	4284											
CDKN2A	1029	broad.mit.edu	37	chr9	21970971	21970971	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccccccgcagccgcgcgcagGtaccgtgcgacatcgcgatg	6	4	13	18	8	0	0	0	0	0	0	1	2	0	0	5	1	3	3	5	1	1	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr9:21970971G>T	uc003zpk.2	-	2	599	c.387C>A	c.(385-387)TAC>TAA	p.Y129*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	129	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.Y129*(5)|p.R128fs*12(3)|p.Y129C(2)|p.R128fs*9(2)|p.Y129H(1)|p.A118fs*10(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCGCGCGCAGGTACCGTGCGA	0.682		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			20	12					1.55795e-14	1.82524e-14	1	0	T	21970971	T	T	21970971	4	4	19	1	0	0	0	0	0	1	0	0	3176	1256	44	4	91	4	CDKN2A	9	21970971	Nonsense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08		21970971	119242460	87	4285											
PRKCQ	5588	broad.mit.edu	37	chr10	6470234	6470234	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaacatattctggtccaTgctgttgatcagtgctctgt	7	15	9	10	0	3	2	1	2	2	0	4	2	4	2	2	1	3	3	2	1	2	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:6470234T>C	uc001ijj.1	-	18	2131	c.2056A>G	c.(2056-2058)ATG>GTG	p.M686V	PRKCQ_uc009xim.1_Missense_Mutation_p.M623V|PRKCQ_uc001iji.1_Missense_Mutation_p.M719V|PRKCQ_uc009xin.1_Missense_Mutation_p.M650V|PRKCQ_uc010qax.1_Missense_Mutation_p.M561V	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	686	AGC-kinase C-terminal.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						TTCTGGTCCATGCTGTTGATC	0.468													122	93					0	0	0	0	C	6470234	C	C	6470234	3	2	19	1	0	0	0	0	1	0	0	0	12577	1464	51	5	68	5	PRKCQ	10	6470234	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08		6470234	129064513	88	4286											
PCDH15	65217	broad.mit.edu	37	chr10	55955582	55955594	+	Frame_Shift_Del	DEL	TTTTCATCCAGTA	-	-																															taaaatatggactttgattgTtttcatccagtatttcaatg																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:55955582_55955594delTTTTCATCCAGTA	uc001jju.1	-	11	1549_1561	c.1154_1166delTACTGGATGAAAA	c.(1153-1167)ATACTGGATGAAAACfs	p.I385fs	PCDH15_uc010qhq.1_Frame_Shift_Del_p.I390fs|PCDH15_uc010qhr.1_Frame_Shift_Del_p.I385fs|PCDH15_uc010qhs.1_Frame_Shift_Del_p.I390fs|PCDH15_uc010qht.1_Frame_Shift_Del_p.I385fs|PCDH15_uc010qhu.1_Frame_Shift_Del_p.I385fs|PCDH15_uc001jjv.1_Frame_Shift_Del_p.I363fs|PCDH15_uc010qhv.1_Frame_Shift_Del_p.I385fs|PCDH15_uc010qhw.1_Frame_Shift_Del_p.I348fs|PCDH15_uc010qhx.1_Frame_Shift_Del_p.I385fs|PCDH15_uc010qhy.1_Frame_Shift_Del_p.I390fs|PCDH15_uc010qhz.1_Frame_Shift_Del_p.I385fs|PCDH15_uc010qia.1_Frame_Shift_Del_p.I363fs|PCDH15_uc010qib.1_Frame_Shift_Del_p.I363fs|PCDH15_uc001jjw.2_Frame_Shift_Del_p.I385fs	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	385_389	Cadherin 3.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACTTTGATTGTTTTCATCCAGTATTTCAATGTG	0.39										HNSCC(58;0.16)			---	---	---								-	55955594	-	-	55955582	7	5	19	1	0	1	0	1	0	0	0	0	11565	1725	60	0	6437	0	PCDH15	10	55955582	Frame_Shift_Del	DEL	TTTTCATCCAGTA	TCGA-BA-6872-01A-11D-1870-08	49485348	55955582	79579165	89	4287											
ASCC1	51008	broad.mit.edu	37	chr10	73892814	73892814	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atagttctctgggggacttaCcattggggtctttcctgaat	7	15	11	8	0	2	1	0	1	2	0	4	2	3	2	2	4	1	1	2	4	3	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:73892814C>G	uc001jst.1	-	9	1063	c.955_splice	c.e9+1	p.A319_splice	ASCC1_uc001jsr.1_Splice_Site_p.A206_splice|ASCC1_uc001jss.1_Splice_Site_p.A291_splice|ASCC1_uc001jsu.1_Splice_Site_p.A291_splice|ASCC1_uc010qju.1_Splice_Site_p.A312_splice			Q8N9N2	ASCC1_HUMAN	RecName: Full=Activating signal cointegrator 1 complex subunit 1; AltName: Full=ASC-1 complex subunit p50; AltName: Full=Trip4 complex subunit p50;						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	RNA binding				0						GGGGGACTTACCATTGGGGTC	0.428													10	81					0	0	0	0	G	73892814	G	G	73892814	5	3	19	1	0	0	0	0	0	0	1	0	1033	521	18	4	213	4	ASCC1	10	73892814	Splice_Site	SNP	C	TCGA-BA-6872-01A-11D-1870-08	17937232	73892814	61641933	90	4288											
DLG5	9231	broad.mit.edu	37	chr10	79616567	79616567	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcccgggtcatcagccgcaGctgaatggagaggttctcca	8	8	12	13	2	3	2	2	1	1	1	5	3	4	2	3	3	2	3	3	3	1	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:79616567G>T	uc001jzk.2	-	3	527	c.457C>A	c.(457-459)CTG>ATG	p.L153M	DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	153					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ATCAGCCGCAGCTGAATGGAG	0.597													7	58					0.00307968	0.0032713	1	0	T	79616567	T	T	79616567	3	4	19	1	0	0	0	0	1	0	0	0	4580	962	34	4	5422	4	DLG5	10	79616567	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	5723753	79616567	55918180	91	4289											
SH2D4B	387694	broad.mit.edu	37	chr10	82330001	82330001	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccctggtgacaagccctaCgaagagatctctgaggagct	10	7	13	11	1	1	3	0	2	1	1	2	6	1	4	2	3	3	1	2	3	3	1	rs149783849	byFrequency	TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:82330001C>T	uc001kck.1	+	2	706	c.276C>T	c.(274-276)TAC>TAT	p.Y92Y	SH2D4B_uc001kcl.1_Silent_p.Y43Y	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	91											0			Colorectal(32;0.229)			ACAAGCCCTACGAAGAGATCT	0.597													36	93					0	0	0	0	T	82330001	T	T	82330001	2	4	19	1	0	0	0	0	0	0	0	1	14301	547	19	1		1	SH2D4B	10	82330001	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	2713434	82330001	53204746	92	4290											
IFIT5	24138	broad.mit.edu	37	chr10	91177539	91177539	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgattctgatagagaagggTctgtaaagagcttttctctg	11	14	11	5	0	3	4	0	2	3	2	4	5	3	4	0	1	1	2	0	1	4	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:91177539T>G	uc010qnh.1	+	2	814	c.583T>G	c.(583-585)TCT>GCT	p.S195A	IFIT5_uc010qng.1_Intron	NM_012420	NP_036552	Q13325	IFIT5_HUMAN	interferon-induced protein with	195	TPR 4.						binding				0						TAGAGAAGGGTCTGTAAAGAG	0.448													5	74					0	0	0	0	G	91177539	G	G	91177539	3	3	19	1	0	0	0	0	1	0	0	0	7564	1667	58	5	589	5	IFIT5	10	91177539	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	8847538	91177539	44357208	93	4291											
BTAF1	9044	broad.mit.edu	37	chr10	93741428	93741428	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaactgttgagtaaggcttCagttcagtatgtggtagcag	10	12	14	5	0	2	1	2	1	0	0	2	2	2	2	0	3	2	7	0	3	4	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:93741428C>T	uc001khr.2	+	16	1882	c.1784C>T	c.(1783-1785)TCA>TTA	p.S595L	BTAF1_uc001khs.1_Missense_Mutation_p.S265L|BTAF1_uc001kht.1_Missense_Mutation_p.S33L	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	595	HEAT 4.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				AGTAAGGCTTCAGTTCAGTAT	0.398													34	183					0	0	0	0	T	93741428	T	T	93741428	3	4	19	1	0	0	0	0	1	0	0	0	1541	838	29	2	1846	2	BTAF1	10	93741428	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	2563889	93741428	41793319	94	4292											
DNTT	1791	broad.mit.edu	37	chr10	98078208	98078208	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcagctcacaaccagagctCctcgatgtctcctggctgat	8	10	9	14	1	3	2	2	1	1	1	6	3	4	2	3	1	3	3	3	1	1	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:98078208C>A	uc001kmf.2	+	2	473	c.303C>A	c.(301-303)CTC>CTA	p.L101L	DNTT_uc001kmg.2_Silent_p.L101L	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	101	BRCT.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		AACCAGAGCTCCTCGATGTCT	0.488													52	110					5.13769e-22	6.07875e-22	1	0	A	98078208	A	A	98078208	2	1	19	1	0	0	0	0	0	0	0	1	4702	842	30	2		2	DNTT	10	98078208	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	4336780	98078208	37456539	95	4293											
SORCS1	114815	broad.mit.edu	37	chr10	108437080	108437080	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgcccttaccaaagatgtCgaattgggagagatgtgtgt	10	12	13	6	1	0	2	0	0	0	2	1	5	0	3	2	1	2	0	2	1	3	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:108437080C>T	uc001kym.2	-	13	1831	c.1823G>A	c.(1822-1824)CGA>CAA	p.R608Q	SORCS1_uc001kyl.2_Missense_Mutation_p.R608Q|SORCS1_uc009xxs.2_Missense_Mutation_p.R608Q|SORCS1_uc001kyn.1_Missense_Mutation_p.R608Q|SORCS1_uc001kyo.2_Missense_Mutation_p.R608Q	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	608	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CCAAAGATGTCGAATTGGGAG	0.463													22	53					0	0	0	0	T	108437080	T	T	108437080	3	4	19	1	0	0	0	0	1	0	0	0	14994	884	31	1	1973	1	SORCS1	10	108437080	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	10358872	108437080	27097667	96	4294											
SORCS1	114815	broad.mit.edu	37	chr10	108489807	108489807	+	Splice_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggcaaagttgatttacttaCgaccatccacagttctggcc	10	11	8	12	2	1	1	0	1	1	0	2	2	2	1	3	2	2	3	3	2	3	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:108489807C>T	uc001kym.2	-	6	1032	c.1024_splice	c.e6+1	p.H342_splice	SORCS1_uc001kyl.2_Splice_Site_p.H342_splice|SORCS1_uc009xxs.2_Splice_Site_p.H342_splice|SORCS1_uc001kyn.1_Splice_Site_p.H342_splice|SORCS1_uc001kyo.2_Splice_Site_p.H342_splice	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a							integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GATTTACTTACGACCATCCAC	0.383													4	81					0	0	0	0	T	108489807	T	T	108489807	5	4	19	1	0	0	0	0	0	0	1	0	14994	550	19	1	2799	1	SORCS1	10	108489807	Splice_Site	SNP	C	TCGA-BA-6872-01A-11D-1870-08	52727	108489807	27044940	97	4295											
C10orf137	26098	broad.mit.edu	37	chr10	127414390	127414390	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttcttcagtttctgaagatCccagtgcttccagtcaggtt	7	15	8	11	0	4	2	2	1	2	1	6	2	6	2	2	1	1	3	2	1	1	5	rs149421957		TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:127414390C>G	uc001liq.1	+	6	1068	c.775C>G	c.(775-777)CCC>GCC	p.P259A	C10orf137_uc001lin.2_Missense_Mutation_p.P259A|C10orf137_uc001lio.1_Missense_Mutation_p.P259A|C10orf137_uc001lip.1_Translation_Start_Site	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TTCTGAAGATCCCAGTGCTTC	0.408													5	63					0	0	0	0	G	127414390	G	G	127414390	3	3	19	1	0	0	0	0	1	0	0	0	1600	855	30	2	797	2	C10orf137	10	127414390	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	18924583	127414390	8120357	98	4296											
UROS	7390	broad.mit.edu	37	chr10	127503624	127503624	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttcagttttattgttttgctCcaaacataactctgctgctt	8	19	5	9	0	2	0	1	0	1	0	3	0	3	0	1	0	5	5	1	0	3	8			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr10:127503624C>G	uc001liw.3	-	3	356	c.223G>C	c.(223-225)GAG>CAG	p.E75Q	UROS_uc001liv.3_5'UTR|UROS_uc010quh.1_RNA|UROS_uc001lix.3_Missense_Mutation_p.E75Q|UROS_uc001liy.3_RNA|UROS_uc001liz.2_RNA	NM_000375	NP_000366	P10746	HEM4_HUMAN	uroporphyrinogen III synthase	75					heme biosynthetic process|uroporphyrinogen III biosynthetic process	cytosol|mitochondrion	uroporphyrinogen-III synthase activity				0		all_lung(145;0.00756)|Lung NSC(174;0.0116)|Colorectal(57;0.0855)|all_neural(114;0.0937)|Breast(234;0.203)				TTGTTTTGCTCCAAACATAAC	0.443													6	59					0	0	0	0	G	127503624	G	G	127503624	3	3	19	1	0	0	0	0	1	0	0	0	17098	864	30	2	602	2	UROS	10	127503624	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	89234	127503624	8031123	99	4297											
MUC5B	727897	broad.mit.edu	37	chr11	1272931	1272931	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccccagctcccacttctctActccctgcttctgcagggca	5	11	6	19	0	2	0	0	0	2	0	6	0	5	0	4	1	4	4	4	1	1	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:1272931A>G	uc009ycr.1	+	52	15913	c.15787A>G	c.(15787-15789)ACT>GCT	p.T5263A	MUC5B_uc001ltb.2_Missense_Mutation_p.T4944A	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4941					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACTTCTCTACTCCCTGCTT	0.582													7	23					0	0	0	0	G	1272931	G	G	1272931	3	3	19	1	0	0	0	0	1	0	0	0	10032	391	14	5	14952	5	MUC5B	11	1272931	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08		1272931	133733585	100	4298											
FAR1	84188	broad.mit.edu	37	chr11	13736146	13736146	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacctccaatcatcttttatAtcattactggattgctgtaa	12	16	4	9	0	3	0	2	0	1	0	4	1	4	1	2	1	3	2	2	1	6	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:13736146A>G	uc001mld.2	+	9	1201	c.1046A>G	c.(1045-1047)TAT>TGT	p.Y349C		NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	349					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						CATCTTTTATATCATTACTGG	0.438													9	29					0	0	0	0	G	13736146	G	G	13736146	3	3	19	1	0	0	0	0	1	0	0	0	5706	449	16	5	1076	5	FAR1	11	13736146	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	12463215	13736146	121270370	101	4299											
PLEKHA7	144100	broad.mit.edu	37	chr11	16816213	16816213	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggcttgctctcagaagttGagagtgaaggcacaggcggg	9	7	17	8	2	1	3	1	2	1	2	2	4	1	3	0	4	1	4	0	4	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:16816213G>C	uc001mmo.2	-	19	2582	c.2567C>G	c.(2566-2568)TCA>TGA	p.S856*	PLEKHA7_uc010rcu.1_Nonsense_Mutation_p.S856*|PLEKHA7_uc001mmm.2_5'Flank|PLEKHA7_uc010rcv.1_Nonsense_Mutation_p.S430*|PLEKHA7_uc001mmn.2_Nonsense_Mutation_p.S564*	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	856	Pro-rich.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						CTCAGAAGTTGAGAGTGAAGG	0.582													7	54					0	0	0	0	C	16816213	C	C	16816213	4	2	19	1	0	0	0	0	0	1	0	0	12116	1294	45	2	818	2	PLEKHA7	11	16816213	Nonsense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	3080067	16816213	118190303	102	4300											
OSBP	5007	broad.mit.edu	37	chr11	59376155	59376155	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagagggtccgaagggtattCtgcagctcagtcttgtcagt	8	11	14	8	1	4	1	2	0	2	1	5	3	5	1	1	2	2	3	1	2	2	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:59376155C>G	uc001noc.1	-	3	1104	c.624G>C	c.(622-624)CAG>CAC	p.Q208H		NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	208					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GAAGGGTATTCTGCAGCTCAG	0.468													7	66					0	0	0	0	G	59376155	G	G	59376155	3	3	19	1	0	0	0	0	1	0	0	0	11327	912	32	2	1847	2	OSBP	11	59376155	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	42559942	59376155	75630361	103	4301											
DDB1	1642	broad.mit.edu	37	chr11	61080987	61080987	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcacctgtcaggatagccatCtgaattgaggggacacatgt	11	10	11	9	0	3	2	2	2	1	0	3	4	3	4	2	3	1	0	2	3	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:61080987C>T	uc001nrc.3	-	16	2279	c.2053G>A	c.(2053-2055)GAT>AAT	p.D685N	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Missense_Mutation_p.D685N	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	685	Interaction with CDT1.|Interaction with CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						GGATAGCCATCTGAATTGAGG	0.433								NER					17	124					0	0	0	0	T	61080987	T	T	61080987	3	4	19	1	0	0	0	0	1	0	0	0	4340	913	32	2	1417	2	DDB1	11	61080987	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	1704832	61080987	73925529	104	4302											
CATSPER1	117144	broad.mit.edu	37	chr11	65793160	65793160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgctggtgggcttcatgatGacgggacctgccatggtggt	6	11	16	8	1	1	2	1	2	0	0	1	3	1	3	2	5	2	2	2	5	0	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:65793160G>A	uc001ogt.2	-	1	829	c.691C>T	c.(691-693)CAT>TAT	p.H231Y		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	231	His-rich.|Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						GCTTCATGATGACGGGACCTG	0.572													40	22					0	0	0	0	A	65793160	A	A	65793160	3	1	19	1	0	0	0	0	1	0	0	0	2699	1290	45	2	1699	2	CATSPER1	11	65793160	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	4712173	65793160	69213356	105	4303											
NADSYN1	55191	broad.mit.edu	37	chr11	71191849	71191849	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaggtggactttgccctcTcgtgccacgaggacttgctg	6	11	13	11	2	1	1	0	1	1	0	2	4	1	3	2	3	3	1	2	3	1	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:71191849T>C	uc001oqn.2	+	11	1048	c.922T>C	c.(922-924)TCG>CCG	p.S308P	NADSYN1_uc001oqo.2_Missense_Mutation_p.S48P|NADSYN1_uc001oqp.2_5'UTR	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	308					NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTTTGCCCTCTCGTGCCACGA	0.592													7	300					0	0	0	0	C	71191849	C	C	71191849	3	2	19	1	0	0	0	0	1	0	0	0	10191	1551	54	5	964	5	NADSYN1	11	71191849	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	5398689	71191849	63814667	106	4304											
FAT3	120114	broad.mit.edu	37	chr11	92577879	92577879	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtccgcgtttctacaggaaCgtgcgttgcacctgcaatgg	7	11	12	11	4	1	0	0	0	1	0	2	1	2	1	2	2	5	4	2	2	3	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:92577879C>T	uc001pdj.3	+	18	11363	c.11346C>T	c.(11344-11346)AAC>AAT	p.N3782N	FAT3_uc001pdi.3_Silent_p.N222N	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3782	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCTACAGGAACGTGCGTTGCA	0.512										TCGA Ovarian(4;0.039)			4	4					0	0	0	0	T	92577879	T	T	92577879	2	4	19	1	0	0	0	0	0	0	0	1	5723	535	19	1		1	FAT3	11	92577879	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	21386030	92577879	42428637	107	4305											
PIWIL4	143689	broad.mit.edu	37	chr11	94349700	94349700	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcagagaacaatgactgatgTtgcagattgcttgaaagttt	13	13	10	5	0	1	5	1	3	0	2	1	6	1	5	0	0	3	4	0	0	3	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:94349700T>C	uc001pfa.2	+	16	2196	c.1985T>C	c.(1984-1986)GTT>GCT	p.V662A	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	662	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ATGACTGATGTTGCAGATTGC	0.343													14	34					0	0	0	0	C	94349700	C	C	94349700	3	2	19	1	0	0	0	0	1	0	0	0	12015	1725	60	5	2047	5	PIWIL4	11	94349700	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	1771821	94349700	40656816	108	4306											
KBTBD3	143879	broad.mit.edu	37	chr11	105924371	105924371	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaacatttccctttgcaacCacctgtcaagaatattttct	12	14	3	12	0	2	1	1	0	1	1	3	1	3	1	3	0	3	1	3	0	5	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:105924371C>T	uc001pja.2	-	4	1685	c.1045G>A	c.(1045-1047)GGT>AGT	p.G349S	KBTBD3_uc001pjb.2_Missense_Mutation_p.G349S|KBTBD3_uc009yxm.2_Missense_Mutation_p.G270S	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	345	Kelch 2.									ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		CCTTTGCAACCACCTGTCAAG	0.423													11	20					0	0	0	0	T	105924371	T	T	105924371	3	4	19	1	0	0	0	0	1	0	0	0	8033	594	21	4	797	4	KBTBD3	11	105924371	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	11574671	105924371	29082145	109	4307											
SC5DL	6309	broad.mit.edu	37	chr11	121174255	121174255	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acactgagctattattttgtCttcgatcatgcattaatgaa	12	16	6	7	1	2	2	1	2	1	0	3	3	2	2	0	0	2	2	0	0	4	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:121174255C>G	uc001pxu.2	+	2	319	c.171C>G	c.(169-171)GTC>GTG	p.V57V	SC5DL_uc001pxs.1_Silent_p.V57V|SC5DL_uc001pxt.2_Silent_p.V57V|SC5DL_uc001pxv.2_Silent_p.V57V	NM_006918	NP_008849	O75845	SC5D_HUMAN	sterol-C5-desaturase	57					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	C-5 sterol desaturase activity|iron ion binding|lathosterol oxidase activity			ovary(1)	1		Breast(109;0.00328)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)	OV - Ovarian serous cystadenocarcinoma(1;0.0334)	BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		ATTATTTTGTCTTCGATCATG	0.289													12	35					0	0	0	0	G	121174255	G	G	121174255	2	3	19	1	0	0	0	0	0	0	0	1	13931	900	32	2		2	SC5DL	11	121174255	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	15249884	121174255	13832261	110	4308											
ROBO4	54538	broad.mit.edu	37	chr11	124757312	124757312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagaggggtgctggagggaGatgacgagtaaccagctcat	13	6	16	6	1	1	3	1	1	0	2	1	6	1	4	1	4	3	3	1	4	2	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr11:124757312G>A	uc001qbg.2	-	14	2280	c.2140C>T	c.(2140-2142)CTC>TTC	p.L714F	ROBO4_uc010sas.1_Missense_Mutation_p.L569F|ROBO4_uc001qbh.2_Missense_Mutation_p.L604F|ROBO4_uc001qbi.2_Missense_Mutation_p.L272F	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	714					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GCTGGAGGGAGATGACGAGTA	0.602													17	49					0	0	0	0	A	124757312	A	A	124757312	3	1	19	1	0	0	0	0	1	0	0	0	13581	942	33	2	903	2	ROBO4	11	124757312	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	3583057	124757312	10249204	111	4309											
FAM90A1	55138	broad.mit.edu	37	chr12	8380429	8380429	+	5'Flank	DEL	C	-	-																															ggctggagggccgaggactaCccccgcttctaggtgagagg																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:8380429delC	uc001qui.2	-						FAM90A1_uc001quh.2_5'Flank	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138								nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		CCGAGGACTACCCCCGCTTCT	0.607													---	---	---								-	8380429	-	-	8380429	6	5	19	0	1	1	0	1	0	0	0	0	5682	522	18	0		0	FAM90A1	12	8380429	5'Flank	DEL	C	TCGA-BA-6872-01A-11D-1870-08		8380429	125471466	112	4310											
ADAMTS20	80070	broad.mit.edu	37	chr12	43822440	43822440	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctcataagaatacttacggGtgaccaatcccctgcttgcc	10	11	7	13	1	1	2	1	1	1	1	3	2	2	2	4	1	4	1	4	1	5	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:43822440G>T	uc010skx.1	-	25	3652	c.3652C>A	c.(3652-3654)CCC>ACC	p.P1218T	ADAMTS20_uc001rno.1_Missense_Mutation_p.P336T|ADAMTS20_uc001rnp.1_Missense_Mutation_p.P372T	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1218	TSP type-1 8.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ATACTTACGGGTGACCAATCC	0.328													4	12					0.00909568	0.0094516	1	0	T	43822440	T	T	43822440	3	4	19	1	0	0	0	0	1	0	0	0	266	1261	44	4	2139	4	ADAMTS20	12	43822440	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	35442011	43822440	90029455	113	4311											
AAAS	8086	broad.mit.edu	37	chr12	53708119	53708119	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggtccagggtccagataaGaatgcagctctggcaggcca	11	6	14	10	0	1	2	0	0	1	2	3	2	3	2	3	4	2	3	3	4	2	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:53708119G>A	uc001scr.3	-	7	815	c.652C>T	c.(652-654)CTT>TTT	p.L218F	AAAS_uc001scs.3_Missense_Mutation_p.L185F	NM_015665	NP_056480	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency,	218	WD 2.				carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				ovary(1)	1						GTCCAGATAAGAATGCAGCTC	0.587													21	119					0	0	0	0	A	53708119	A	A	53708119	3	1	19	1	0	0	0	0	1	0	0	0	8	942	33	2	1028	2	AAAS	12	53708119	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	9885679	53708119	80143776	114	4312											
TRHDE	29953	broad.mit.edu	37	chr12	73012775	73012775	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagccgagctctttatcctcTagataaattactggaccgca	11	11	7	12	2	2	1	0	0	2	1	3	3	3	2	3	1	3	2	3	1	5	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:73012775T>C	uc001sxa.2	+	13	2321	c.2291T>C	c.(2290-2292)CTA>CCA	p.L764P		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	764	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CTTTATCCTCTAGATAAATTA	0.353													9	45					0	0	0	0	C	73012775	C	C	73012775	3	2	19	1	0	0	0	0	1	0	0	0	16546	1522	53	5	2341	5	TRHDE	12	73012775	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	19304656	73012775	60839120	115	4313											
TRHDE	29953	broad.mit.edu	37	chr12	73015465	73015465	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatgctggcctgcagttttgGcaacaagcactgtcaccaac	11	9	9	12	0	1	0	1	0	0	0	1	0	1	0	2	2	5	5	2	2	4	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:73015465G>T	uc001sxa.2	+	15	2504	c.2474G>T	c.(2473-2475)GGC>GTC	p.G825V		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	825	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TGCAGTTTTGGCAACAAGCAC	0.373													6	24					0.00198382	0.00211666	1	0	T	73015465	T	T	73015465	3	4	19	1	0	0	0	0	1	0	0	0	16546	1203	42	4	2532	4	TRHDE	12	73015465	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	2690	73015465	60836430	116	4314											
TMCC3	57458	broad.mit.edu	37	chr12	94965347	94965347	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgggtgagacgaacttcGcgatggtggacacacacact	11	8	12	10	3	1	1	1	1	0	1	2	5	1	2	0	3	1	0	0	3	1	1	rs149413079	byFrequency	TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:94965347G>A	uc001tdj.2	-	4	1416	c.1298C>T	c.(1297-1299)GCG>GTG	p.A433V	TMCC3_uc001tdi.2_Missense_Mutation_p.A402V	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	433	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2						GACGAACTTCGCGATGGTGGA	0.488													21	77					0	0	0	0	A	94965347	A	A	94965347	3	1	19	1	0	0	0	0	1	0	0	0	16060	1087	38	1	139	1	TMCC3	12	94965347	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	21949882	94965347	38886548	117	4315											
C12orf42	374470	broad.mit.edu	37	chr12	103695998	103695998	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaacctttattaacctcttgGaggggaaatgggtggaagca	13	10	12	6	0	1	0	0	0	1	0	1	3	1	3	2	5	3	1	2	5	5	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:103695998G>T	uc001tjt.2	-	6	1059	c.971C>A	c.(970-972)TCC>TAC	p.S324Y	C12orf42_uc001tjs.2_Intron|C12orf42_uc009zuf.1_Missense_Mutation_p.S324Y|C12orf42_uc001tju.2_Missense_Mutation_p.S229Y	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	324										ovary(1)|central_nervous_system(1)	2						TAACCTCTTGGAGGGGAAATG	0.622													22	54					2.89027e-11	3.35327e-11	1	0	T	103695998	T	T	103695998	3	4	19	1	0	0	0	0	1	0	0	0	1694	1174	41	2	115	2	C12orf42	12	103695998	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	8730651	103695998	30155897	118	4316											
APPL2	55198	broad.mit.edu	37	chr12	105591721	105591721	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccaggtggtggtgaccaGccctgttttgctgtgagttg	4	13	14	10	0	0	2	0	2	0	0	1	2	1	2	3	3	2	3	3	3	0	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:105591721G>C	uc001tlf.1	-	11	1092	c.874C>G	c.(874-876)CTG>GTG	p.L292V	APPL2_uc010swt.1_Missense_Mutation_p.L249V|APPL2_uc001tlg.1_Missense_Mutation_p.L46V|APPL2_uc010swu.1_Missense_Mutation_p.L298V|APPL2_uc009zuq.2_Missense_Mutation_p.L249V	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	292	Required for RAB5A binding (By similarity).|PH.				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						GTGGTGACCAGCCCTGTTTTG	0.542													5	27					0	0	0	0	C	105591721	C	C	105591721	3	2	19	1	0	0	0	0	1	0	0	0	818	962	34	4	1164	4	APPL2	12	105591721	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1895723	105591721	28260174	119	4317											
PRDM4	11108	broad.mit.edu	37	chr12	108145684	108145684	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aacaccgtccatcgtaagctCctctgccattccatctgtcg	8	11	6	16	3	2	0	0	0	2	0	7	0	5	0	5	0	3	2	5	0	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:108145684C>T	uc001tmp.2	-	5	1071	c.634G>A	c.(634-636)GAG>AAG	p.E212K	PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	212					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						ATCGTAAGCTCCTCTGCCATT	0.512													8	89					0	0	0	0	T	108145684	T	T	108145684	3	4	19	1	0	0	0	0	1	0	0	0	12521	864	30	2	1803	2	PRDM4	12	108145684	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	2553963	108145684	25706211	120	4318											
TMEM119	338773	broad.mit.edu	37	chr12	108985942	108985942	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggggtgatgggccccccaggGttatgggctggggccccatc	4	7	18	12	0	0	1	0	1	0	0	1	1	0	1	5	7	0	2	5	7	1	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:108985942G>A	uc001tng.2	-	2	381	c.218C>T	c.(217-219)ACC>ATC	p.T73I	TMEM119_uc001tnf.2_RNA	NM_181724	NP_859075	Q4V9L6	TM119_HUMAN	transmembrane protein 119 precursor	73	Extracellular (Potential).					integral to membrane				ovary(1)	1						GCCCCCCAGGGTTATGGGCTG	0.677													14	55					0	0	0	0	A	108985942	A	A	108985942	3	1	19	1	0	0	0	0	1	0	0	0	16098	1261	44	4	637	4	TMEM119	12	108985942	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	840258	108985942	24865953	121	4319											
ANAPC7	51434	broad.mit.edu	37	chr12	110834183	110834183	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acttactcacagcattccgaTattccttatcatgaaagaga	14	12	5	10	1	2	2	2	1	0	1	4	4	4	2	2	0	2	1	2	0	4	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:110834183T>C	uc001tqo.2	-	2	279	c.278A>G	c.(277-279)TAT>TGT	p.Y93C	ANAPC7_uc001tqp.3_Missense_Mutation_p.Y93C	NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	anaphase-promoting complex subunit 7 isoform a	93	TPR 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0						AGCATTCCGATATTCCTTATC	0.383													15	22					0	0	0	0	C	110834183	C	C	110834183	3	2	19	1	0	0	0	0	1	0	0	0	606	1406	49	5	1565	5	ANAPC7	12	110834183	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	1848241	110834183	23017712	122	4320											
VPS29	51699	broad.mit.edu	37	chr12	110929916	110929916	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatccatcaacacaaatgatGgaataatgtttctagaagaa	18	11	6	6	0	2	3	1	1	1	2	3	4	3	4	1	1	1	1	1	1	8	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:110929916G>A	uc001tqy.2	-	4	503	c.443C>T	c.(442-444)CCA>CTA	p.P148L	VPS29_uc001tqw.2_RNA|VPS29_uc001tqx.2_Missense_Mutation_p.P152L|VPS29_uc001tqz.2_RNA	NM_016226	NP_057310	Q9UBQ0	VPS29_HUMAN	vacuolar protein sorting 29 isoform 1	148					protein transport	endosome membrane	metal ion binding|phosphoserine phosphatase activity				0						CACAAATGATGGAATAATGTT	0.328													5	29					0	0	0	0	A	110929916	A	A	110929916	3	1	19	1	0	0	0	0	1	0	0	0	17268	1348	47	4	109	4	VPS29	12	110929916	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	95733	110929916	22921979	123	4321											
KSR2	283455	broad.mit.edu	37	chr12	117909103	117909103	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgaaaggccattccctggCgtggagttcataccagattg	9	11	11	10	1	1	2	1	1	0	1	2	3	2	3	3	3	1	1	3	3	2	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:117909103C>T	uc001two.2	-	18	2573	c.2518G>A	c.(2518-2520)GCC>ACC	p.A840T		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	869	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CATTCCCTGGCGTGGAGTTCA	0.502													17	32					0	0	0	0	T	117909103	T	T	117909103	3	4	19	1	0	0	0	0	1	0	0	0	8622	768	27	1	259	1	KSR2	12	117909103	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	6979187	117909103	15942792	124	4322											
C12orf43	64897	broad.mit.edu	37	chr12	121442193	121442193	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttcttctttgcctccttCtccactgttccagggctgtg	2	18	7	14	0	3	0	0	0	3	0	6	0	5	0	4	1	1	2	4	1	0	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:121442193C>T	uc001tzh.1	-	6	575	c.552G>A	c.(550-552)GAG>GAA	p.E184E	C12orf43_uc009zxa.1_Silent_p.E215E|C12orf43_uc010szo.1_Silent_p.E143E|C12orf43_uc010szp.1_Silent_p.E174E|C12orf43_uc001tzi.1_Silent_p.E185E	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	184											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TTGCCTCCTTCTCCACTGTTC	0.602													39	138					0	0	0	0	T	121442193	T	T	121442193	2	4	19	1	0	0	0	0	0	0	0	1	1695	912	32	2		2	C12orf43	12	121442193	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	3533090	121442193	12409702	125	4323											
UBC	7316	broad.mit.edu	37	chr12	125397265	125397265	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaccatcttccagctgtttTccggcaaagatcaacctctg	9	11	7	14	2	3	1	1	0	2	1	5	2	5	1	4	1	2	3	4	1	2	3	rs140629410		TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr12:125397265T>C	uc001ugs.3	-	2	1501	c.1053A>G	c.(1051-1053)GGA>GGG	p.G351G	UBC_uc001ugr.2_Intron|UBC_uc001ugu.1_Silent_p.G351G|UBC_uc001ugt.2_Silent_p.G351G|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Silent_p.G199G	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	351	Ubiquitin-like 5.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CCAGCTGTTTTCCGGCAAAGA	0.527													31	180					0	0	0	0	C	125397265	C	C	125397265	2	2	19	1	0	0	0	0	0	0	0	1	16910	1770	62	5		5	UBC	12	125397265	Silent	SNP	T	TCGA-BA-6872-01A-11D-1870-08	3955072	125397265	8454630	126	4324											
FAM155A	728215	broad.mit.edu	37	chr13	108518304	108518304	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatccgacaagttccagagcGgagtgggatgcttgctcctc	9	9	12	11	2	0	1	0	0	0	1	4	4	3	3	3	2	3	3	3	2	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr13:108518304G>A	uc001vql.2	-	1	1157	c.641C>T	c.(640-642)CCG>CTG	p.P214L		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	214						integral to membrane	binding			skin(1)	1						GTTCCAGAGCGGAGTGGGATG	0.577													16	106					0	0	0	0	A	108518304	A	A	108518304	3	1	19	1	0	0	0	0	1	0	0	0	5493	1116	39	1	747	1	FAM155A	13	108518304	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08		108518304	6651574	127	4325											
RHOJ	57381	broad.mit.edu	37	chr14	63747788	63747788	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctcttaccacaatgtccagGaggaatgggtccccgagctc	9	8	10	14	1	1	0	0	0	1	0	4	3	3	2	5	3	2	1	5	3	3	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr14:63747788G>A	uc001xgb.1	+	3	780	c.337G>A	c.(337-339)GAG>AAG	p.E113K		NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	ras homolog gene family, member J precursor	113					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		CAATGTCCAGGAGGAATGGGT	0.557													25	67					0	0	0	0	A	63747788	A	A	63747788	3	1	19	1	0	0	0	0	1	0	0	0	13406	1175	41	2	347	2	RHOJ	14	63747788	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08		63747788	43601752	128	4326											
RHOJ	57381	broad.mit.edu	37	chr14	63747813	63747813	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgggtccccgagctcaaggActgcatgcctcacgtgcctt	7	9	11	14	2	2	0	2	0	0	0	3	2	3	1	4	2	4	2	4	2	1	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr14:63747813A>G	uc001xgb.1	+	3	805	c.362A>G	c.(361-363)GAC>GGC	p.D121G		NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	ras homolog gene family, member J precursor	121					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		GAGCTCAAGGACTGCATGCCT	0.537													24	55					0	0	0	0	G	63747813	G	G	63747813	3	3	19	1	0	0	0	0	1	0	0	0	13406	275	10	5	372	5	RHOJ	14	63747813	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	25	63747813	43601727	129	4327											
SYNE2	23224	broad.mit.edu	37	chr14	64532170	64532170	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccttggtgtcaaatcttatAtcaaccaaagaagagttaat	15	12	7	7	0	3	2	2	0	1	2	3	2	3	2	2	1	1	1	2	1	7	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr14:64532170A>G	uc001xgm.2	+	51	10463	c.10233A>G	c.(10231-10233)ATA>ATG	p.I3411M	SYNE2_uc001xgl.2_Missense_Mutation_p.I3411M|SYNE2_uc010apw.1_Missense_Mutation_p.I117M	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3411	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAAATCTTATATCAACCAAAG	0.353													24	22					0	0	0	0	G	64532170	G	G	64532170	3	3	19	1	0	0	0	0	1	0	0	0	15512	439	16	5	10431	5	SYNE2	14	64532170	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	784357	64532170	42817370	130	4328											
ACOT4	122970	broad.mit.edu	37	chr14	74061758	74061758	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttcttttcttccaggtaaaAggcccaggcattgggctttt	7	15	9	10	0	2	0	0	0	2	0	3	0	3	0	2	4	0	3	2	4	2	8			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr14:74061758A>G	uc001xoo.2	+	3	920	c.666A>G	c.(664-666)AAA>AAG	p.K222K		NM_152331	NP_689544	Q8N9L9	ACOT4_HUMAN	acyl-CoA thioesterase 4	222					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)		TCCAGGTAAAAGGCCCAGGCA	0.328													3	181					0	0	0	0	G	74061758	G	G	74061758	2	3	19	1	0	0	0	0	0	0	0	1	153	69	3	5		5	ACOT4	14	74061758	Silent	SNP	A	TCGA-BA-6872-01A-11D-1870-08	9529588	74061758	33287782	131	4329											
FAM82A2	55177	broad.mit.edu	37	chr15	41029852	41029852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaagctctggagggcatcttCcacagtggcactgagagggc	9	7	15	10	0	2	1	0	1	2	1	3	4	3	2	1	4	1	3	1	4	1	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr15:41029852C>T	uc001zmo.1	-	10	1342	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	FAM82A2_uc001zmp.1_Missense_Mutation_p.E400K|FAM82A2_uc001zmq.1_Missense_Mutation_p.E400K	NM_018145	NP_060615	Q96TC7	RMD3_HUMAN	family with sequence similarity 82, member A2	400					apoptosis|cell differentiation	integral to membrane|microtubule|mitochondrial membrane|nucleus|spindle pole	protein binding				0						AGGGCATCTTCCACAGTGGCA	0.478													5	76					0	0	0	0	T	41029852	T	T	41029852	3	4	19	1	0	0	0	0	1	0	0	0	5663	864	30	2	230	2	FAM82A2	15	41029852	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08		41029852	61501540	132	4330											
MAP1A	4130	broad.mit.edu	37	chr15	43815715	43815716	+	Frame_Shift_Ins	INS	-	A	A																															aaaagctgagggtttttaccINSaaaaacatatgcaggaaccc																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr15:43815715_43815716insA	uc001zrt.2	+	4	2511_2512	c.2044_2045insA	c.(2044-2046)CAAfs	p.Q682fs		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	682				Q -> P (in Ref. 1; AAB41132/AAB41133).		cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGGTTTTTACCAAAAACATATG	0.515													---	---	---								A	43815716	A	A	43815715	7	5	19	1	0	1	1	0	0	0	0	0	9280	595	21	0	2046	0	MAP1A	15	43815715	Frame_Shift_Ins	INS	-	TCGA-BA-6872-01A-11D-1870-08	2785863	43815715	58715677	133	4331											
CASC4	113201	broad.mit.edu	37	chr15	44671915	44671915	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagcctcctatttcagtttCtcaacatgaaagtcatcaag	13	12	6	10	0	4	1	4	1	1	0	6	2	5	1	2	0	2	1	2	0	5	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr15:44671915C>G	uc001zto.1	+	7	1129	c.830C>G	c.(829-831)TCT>TGT	p.S277C	CASC4_uc001ztp.2_Missense_Mutation_p.S277C|CASC4_uc001ztq.2_Missense_Mutation_p.S277C	NM_138423	NP_612432	Q6P4E1	CASC4_HUMAN	cancer susceptibility candidate 4 isoform a	277	Lumenal (Potential).					integral to membrane				ovary(1)	1		all_cancers(109;1.69e-13)|all_epithelial(112;3.94e-11)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.027)		all cancers(107;2.91e-20)|GBM - Glioblastoma multiforme(94;1.57e-06)|COAD - Colon adenocarcinoma(120;0.217)|Colorectal(105;0.237)		ATTTCAGTTTCTCAACATGAA	0.333													67	76					0	0	0	0	G	44671915	G	G	44671915	3	3	19	1	0	0	0	0	1	0	0	0	2674	913	32	2	856	2	CASC4	15	44671915	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	856200	44671915	57859477	134	4332											
PLDN	26258	broad.mit.edu	37	chr15	45884445	45884445	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattatttgccagatctgcaGagatcaaaacaagccctcca	14	9	6	12	0	2	2	1	0	1	2	3	3	3	2	3	0	4	1	3	0	4	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr15:45884445G>C	uc001zvq.2	+	2	420	c.195G>C	c.(193-195)CAG>CAC	p.Q65H	PLDN_uc001zvr.2_RNA|PLDN_uc001zvs.2_RNA	NM_012388	NP_036520	Q9UL45	PLDN_HUMAN	pallidin	65	Potential.				post-Golgi vesicle-mediated transport|synaptic vesicle docking involved in exocytosis	BLOC-1 complex|endomembrane system|membrane	identical protein binding|syntaxin-13 binding			skin(1)	1		Lung NSC(122;1.6e-06)|all_lung(180;1.13e-05)|Melanoma(134;0.027)		all cancers(107;6.58e-18)|GBM - Glioblastoma multiforme(94;5.91e-07)		CAGATCTGCAGAGATCAAAAC	0.398													8	29					0	0	0	0	C	45884445	C	C	45884445	3	2	19	1	0	0	0	0	1	0	0	0	12106	933	33	2	201	2	PLDN	15	45884445	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1212530	45884445	56646947	135	4333											
UNC13C	440279	broad.mit.edu	37	chr15	54305645	54305645	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttaaaactgggagctttacGaaaactgagaaaatggaaaa	19	8	9	5	1	0	1	0	1	0	1	0	5	0	3	0	2	4	1	0	2	9	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr15:54305645G>A	uc002ack.2	+	1	545	c.545G>A	c.(544-546)CGA>CAA	p.R182Q		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	182					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGAGCTTTACGAAAACTGAGA	0.458													48	82					0	0	0	0	A	54305645	A	A	54305645	3	1	19	1	0	0	0	0	1	0	0	0	17054	1058	37	1	547	1	UNC13C	15	54305645	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	8421200	54305645	48225747	136	4334											
VPS13C	54832	broad.mit.edu	37	chr15	62165518	62165518	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcgactcaactcttctcttCttttttgctgatattccttg	5	20	5	11	1	4	1	1	1	3	0	7	2	5	1	1	0	2	1	1	0	2	8			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr15:62165518C>G	uc002agz.2	-	78	10579	c.10505G>C	c.(10504-10506)AGA>ACA	p.R3502T	VPS13C_uc002aha.2_Missense_Mutation_p.R3459T|VPS13C_uc002ahb.1_Missense_Mutation_p.R3502T|VPS13C_uc002ahc.1_Missense_Mutation_p.R3459T	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3502					protein localization					ovary(2)	2						CTCTTCTCTTCTTTTTTGCTG	0.423													46	154					0	0	0	0	G	62165518	G	G	62165518	3	3	19	1	0	0	0	0	1	0	0	0	17259	913	32	2	816	2	VPS13C	15	62165518	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	7859873	62165518	40365874	137	4335											
DENND4A	10260	broad.mit.edu	37	chr15	65968902	65968902	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcatggcagacatcttcaTctgttaaagaggtagattca	13	12	8	8	0	5	3	3	0	2	3	5	3	5	3	0	2	0	3	0	2	3	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr15:65968902T>C	uc002aph.2	-	23	4496	c.4118A>G	c.(4117-4119)GAT>GGT	p.D1373G	DENND4A_uc002api.2_Missense_Mutation_p.D1416G	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GACATCTTCATCTGTTAAAGA	0.423													7	31					0	0	0	0	C	65968902	C	C	65968902	3	2	19	1	0	0	0	0	1	0	0	0	4455	1435	50	5	1513	5	DENND4A	15	65968902	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	3803384	65968902	36562490	138	4336											
STARD5	80765	broad.mit.edu	37	chr15	81614833	81614833	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaacagctggcttcacacaGtcccacacctcctctagtgt	9	9	6	17	0	2	0	1	0	1	0	4	0	4	0	4	1	2	2	4	1	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr15:81614833G>A	uc002bgm.2	-	3	282	c.198C>T	c.(196-198)GAC>GAT	p.D66D	STARD5_uc002bgn.2_5'UTR	NM_181900	NP_871629	Q9NSY2	STAR5_HUMAN	StAR-related lipid transfer protein 5	66	START.				C21-steroid hormone biosynthetic process|lipid transport	cytosol	lipid binding			ovary(1)	1						GCTTCACACAGTCCCACACCT	0.473													19	75					0	0	0	0	A	81614833	A	A	81614833	2	1	19	1	0	0	0	0	0	0	0	1	15326	1020	36	4		4	STARD5	15	81614833	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08	15645931	81614833	20916559	139	4337											
IQGAP1	8826	broad.mit.edu	37	chr15	90934059	90934060	+	Frame_Shift_Ins	INS	-	A	A																															gatggatgaaaggagacgtcINSagaacgtggcttatgagtac																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr15:90934059_90934060insA	uc002bpl.1	+	2	210_211	c.109_110insA	c.(109-111)CAGfs	p.Q37fs		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	37					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AAGGAGACGTCAGAACGTGGCT	0.426													---	---	---								A	90934060	A	A	90934059	7	5	19	1	0	1	1	0	0	0	0	0	7853	827	29	0	115	0	IQGAP1	15	90934059	Frame_Shift_Ins	INS	-	TCGA-BA-6872-01A-11D-1870-08	9319226	90934059	11597333	140	4338											
NAT15	79903	broad.mit.edu	37	chr16	3533528	3533528	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cccctattactactccattcGaggggtcctcaaagatggct	9	11	8	13	1	1	1	1	0	0	1	4	2	3	1	4	3	2	1	4	3	4	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr16:3533528G>C	uc002cvh.3	+	6	749	c.503G>C	c.(502-504)CGA>CCA	p.R168P	NAT15_uc010uxb.1_Missense_Mutation_p.R175P|NAT15_uc010btk.1_Missense_Mutation_p.R103P|NAT15_uc010btl.2_Intron|NAT15_uc010btm.2_Missense_Mutation_p.R168P|NAT15_uc010uxc.1_Missense_Mutation_p.R168P|NAT15_uc010uxd.1_Intron|NAT15_uc010uxe.1_Intron|NAT15_uc002cvg.1_Missense_Mutation_p.R168P	NM_001083601	NP_001077070	Q9H7X0	NAT15_HUMAN	N-acetyltransferase 15	168	N-acetyltransferase.						N-acetyltransferase activity				0						TACTCCATTCGAGGGGTCCTC	0.478													5	70					0	0	0	0	C	3533528	C	C	3533528	3	2	19	1	0	0	0	0	1	0	0	0	10229	1058	37	3	517	3	NAT15	16	3533528	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08		3533528	86821225	141	4339											
ACSM5	54988	broad.mit.edu	37	chr16	20442541	20442541	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgatgatttccttaccaGattgtggatgatgagggcaa	10	13	12	6	0	0	5	0	4	0	1	1	6	1	6	2	2	1	1	2	2	2	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr16:20442541G>A	uc002dhe.2	+	10	1354	c.1207_splice	c.e10-1	p.I403_splice		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5						fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TTCCTTACCAGATTGTGGATG	0.552													23	102					0	0	0	0	A	20442541	A	A	20442541	5	1	19	1	0	0	0	0	0	0	1	0	187	956	33	2	1240	2	ACSM5	16	20442541	Splice_Site	SNP	G	TCGA-BA-6872-01A-11D-1870-08	16909013	20442541	69912212	142	4340											
PALB2	79728	broad.mit.edu	37	chr16	23641719	23641719	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatggagccgtgaaagcatCatcatccaaggataaataag	18	7	9	7	1	2	1	2	1	0	0	3	3	3	3	2	2	2	1	2	2	6	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr16:23641719C>T	uc002dlx.1	-	5	1956	c.1756G>A	c.(1756-1758)GAT>AAT	p.D586N		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	586					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		GTGAAAGCATCATCATCCAAG	0.368			F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				7	24					0	0	0	0	T	23641719	T	T	23641719	3	4	19	1	0	0	0	0	1	0	0	0	11460	826	29	2	1840	2	PALB2	16	23641719	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	3199178	23641719	66713034	143	4341											
ZNF423	23090	broad.mit.edu	37	chr16	49764716	49764716	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgggcccggtggtccgtcagGtctgccagagactcgaagtc	6	8	15	12	3	2	1	1	0	1	1	5	3	3	1	3	4	1	0	3	4	1	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr16:49764716G>C	uc002efs.2	-	4	541	c.243C>G	c.(241-243)GAC>GAG	p.D81E		NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	81	C2H2-type 1; degenerate.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GGTCCGTCAGGTCTGCCAGAG	0.517													5	105					0	0	0	0	C	49764716	C	C	49764716	3	2	19	1	0	0	0	0	1	0	0	0	17965	1252	44	4	3635	4	ZNF423	16	49764716	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	26122997	49764716	40590037	144	4342											
PLCG2	5336	broad.mit.edu	37	chr16	81957192	81957192	+	Frame_Shift_Del	DEL	G	-	-																															acaatgtctccaaggagcccGggggctggtaaggctgagtg																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr16:81957192delG	uc002fgt.2	+	22	2562	c.2410delG	c.(2410-2412)GGGfs	p.G804fs		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	804	SH3.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						CAAGGAGCCCGGGGGCTGGTA	0.582													---	---	---								-	81957192	-	-	81957192	7	5	19	1	0	1	0	1	0	0	0	0	12091	1116	39	0	2492	0	PLCG2	16	81957192	Frame_Shift_Del	DEL	G	TCGA-BA-6872-01A-11D-1870-08	32192476	81957192	8397561	145	4343											
ALOX12	239	broad.mit.edu	37	chr17	6900305	6900305	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccttcccgtgctaccgctGggtgcagggcgaggacatcc	5	7	15	14	3	0	0	0	0	0	0	2	2	2	1	4	4	3	3	4	4	1	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:6900305G>A	uc002gdx.3	+	2	349	c.296G>A	c.(295-297)TGG>TAG	p.W99*		NM_000697	NP_000688	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	99	PLAT.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			central_nervous_system(1)	1						TGCTACCGCTGGGTGCAGGGC	0.706													5	3					0	0	0	0	A	6900305	A	A	6900305	4	1	19	1	0	0	0	0	0	1	0	0	536	1357	47	4	302	4	ALOX12	17	6900305	Nonsense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08		6900305	74294905	146	4344											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	7	7	13	14	3	3	0	3	0	0	0	4	0	4	0	3	3	3	2	3	3	1	0	rs28934578		TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			32	25					0	0	0	0	T	7578406	T	T	7578406	3	4	19	1	0	0	0	0	1	0	0	0	16448	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	678101	7578406	73616804	147	4345											
MYH8	4626	broad.mit.edu	37	chr17	10302117	10302117	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctagttgatgtttcagctCttcaatctgctgagtagatg	8	16	9	8	0	5	3	2	2	3	1	5	3	5	3	0	0	2	5	0	0	3	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:10302117C>T	uc002gmm.2	-	29	4044	c.3949G>A	c.(3949-3951)GAG>AAG	p.E1317K	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1317	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TGTTTCAGCTCTTCAATCTGC	0.388									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				6	55					0	0	0	0	T	10302117	T	T	10302117	3	4	19	1	0	0	0	0	1	0	0	0	10094	922	32	2	1912	2	MYH8	17	10302117	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	2723711	10302117	70893093	148	4346											
C17orf48	56985	broad.mit.edu	37	chr17	10608466	10608466	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgtccttcagcttggagatAtcatcgatggatataatgca	11	13	10	7	1	2	1	2	0	0	1	4	4	3	2	1	2	2	2	1	2	3	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:10608466A>G	uc002gmt.2	+	2	298	c.223A>G	c.(223-225)ATC>GTC	p.I75V	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA|C17orf48_uc010vvg.1_Missense_Mutation_p.I75V	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	75							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						GCTTGGAGATATCATCGATGG	0.418													20	95					0	0	0	0	G	10608466	G	G	10608466	3	3	19	1	0	0	0	0	1	0	0	0	1866	449	16	5	225	5	C17orf48	17	10608466	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	306349	10608466	70586744	149	4347											
CCDC144A	9720	broad.mit.edu	37	chr17	16612243	16612243	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attagagtggaaaaaccaatTaaaactcgtcataaatgagt	19	10	7	5	1	1	2	1	1	0	1	2	3	1	3	1	1	2	0	1	1	8	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:16612243T>C	uc002gqk.1	+	5	948	c.872T>C	c.(871-873)TTA>TCA	p.L291S	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	291											0						AAAAACCAATTAAAACTCGTC	0.363													39	60					0	0	0	0	C	16612243	C	C	16612243	3	2	19	1	0	0	0	0	1	0	0	0	2789	1764	61	5	890	5	CCDC144A	17	16612243	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	6003777	16612243	64582967	150	4348											
SUPT6H	6830	broad.mit.edu	37	chr17	27017211	27017211	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acacagaggagatcttcaatAtgttaaccaaagaaacacca	19	7	6	9	0	2	3	1	0	1	3	2	4	2	3	2	1	2	1	2	1	5	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:27017211A>G	uc002hby.2	+	26	3544	c.3454A>G	c.(3454-3456)ATG>GTG	p.M1152V	SUPT6H_uc010crt.2_Missense_Mutation_p.M1152V|SUPT6H_uc002hbz.1_Missense_Mutation_p.M84V	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1152					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					GATCTTCAATATGTTAACCAA	0.458													26	57					0	0	0	0	G	27017211	G	G	27017211	3	3	19	1	0	0	0	0	1	0	0	0	15466	449	16	5	3552	5	SUPT6H	17	27017211	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	10404968	27017211	54177999	151	4349											
ACACA	31	broad.mit.edu	37	chr17	35564685	35564685	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagctacatgggtcatgccaTagtggttgaggttggaggag	9	11	16	5	0	1	1	1	1	0	0	1	3	1	3	1	5	3	3	1	5	3	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:35564685T>C	uc002hnm.2	-	31	3817	c.3626A>G	c.(3625-3627)TAT>TGT	p.Y1209C	ACACA_uc002hnk.2_Missense_Mutation_p.Y1131C|ACACA_uc002hnl.2_Missense_Mutation_p.Y1151C|ACACA_uc002hnn.2_Missense_Mutation_p.Y1209C|ACACA_uc002hno.2_Missense_Mutation_p.Y1246C|ACACA_uc010cuy.2_5'Flank	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1209					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GGTCATGCCATAGTGGTTGAG	0.473													21	84					0	0	0	0	C	35564685	C	C	35564685	3	2	19	1	0	0	0	0	1	0	0	0	106	1406	49	5	3518	5	ACACA	17	35564685	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	8547474	35564685	45630525	152	4350											
KRT25	147183	broad.mit.edu	37	chr17	38906826	38906826	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagttgctctcggtctctgtCaaggagcactccagggagtg	7	11	13	10	1	3	0	1	0	2	0	6	2	4	2	1	3	2	3	1	3	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:38906826C>G	uc002hve.2	-	6	1042	c.981G>C	c.(979-981)TTG>TTC	p.L327F		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	327	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				CGGTCTCTGTCAAGGAGCACT	0.522													18	216					0	0	0	0	G	38906826	G	G	38906826	3	3	19	1	0	0	0	0	1	0	0	0	8501	825	29	2	383	2	KRT25	17	38906826	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	3342141	38906826	42288384	153	4351											
JUP	3728	broad.mit.edu	37	chr17	39912040	39912040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtacgggggcctgaggcCgtcgctgtaggtgtcgatgg	4	8	21	8	4	0	1	0	1	0	0	2	2	0	1	2	7	1	3	2	7	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:39912040C>T	uc002hxq.2	-	14	2471	c.2194G>A	c.(2194-2196)GGC>AGC	p.G732S	JUP_uc010wfs.1_Intron|JUP_uc002hxr.2_Missense_Mutation_p.G732S|JUP_uc002hxs.2_Missense_Mutation_p.G732S	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	732					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GGCCTGAGGCCGTCGCTGTAG	0.632													12	51					0	0	0	0	T	39912040	T	T	39912040	3	4	19	1	0	0	0	0	1	0	0	0	8011	652	23	1	47	1	JUP	17	39912040	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	1005214	39912040	41283170	154	4352											
BRCA1	672	broad.mit.edu	37	chr17	41244991	41244991	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attctgcaaatactgagcatCaagttcactttcttccattt	11	16	4	10	0	4	1	2	1	2	0	5	1	5	1	1	0	3	3	1	0	3	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:41244991C>T	uc002icq.2	-	10	2789	c.2557G>A	c.(2557-2559)GAT>AAT	p.D853N	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.D782N|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.D806N|BRCA1_uc002ict.2_Missense_Mutation_p.D853N|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.D853N|BRCA1_uc002ide.1_Missense_Mutation_p.D684N|BRCA1_uc010cyy.1_Missense_Mutation_p.D853N|BRCA1_uc010whs.1_Missense_Mutation_p.D853N|BRCA1_uc010cyz.2_Missense_Mutation_p.D806N|BRCA1_uc010cza.2_Missense_Mutation_p.D827N|BRCA1_uc010wht.1_Missense_Mutation_p.D557N	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	853					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TACTGAGCATCAAGTTCACTT	0.393			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			50	133					0	0	0	0	T	41244991	T	T	41244991	3	4	19	1	0	0	0	0	1	0	0	0	1503	826	29	2	3160	2	BRCA1	17	41244991	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	1332951	41244991	39950219	155	4353											
HEXIM1	10614	broad.mit.edu	37	chr17	43226740	43226743	+	Frame_Shift_Del	DEL	GGAG	-	-																															ttgggtggccgtccggggccGgagggggaagggagcctgga																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:43226740_43226743delGGAG	uc002iig.2	+	1	2057_2060	c.183_186delGGAG	c.(181-186)CCGGAGfs	p.P61fs		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	61_62					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						GTCCGGGGCCGGAGGGGGAAGGGA	0.676											OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	43226743	-	-	43226740	7	5	19	1	0	1	0	1	0	0	0	0	7115	1103	39	0	185	0	HEXIM1	17	43226740	Frame_Shift_Del	DEL	GGAG	TCGA-BA-6872-01A-11D-1870-08	1981749	43226740	37968470	156	4354											
LUC7L3	51747	broad.mit.edu	37	chr17	48821155	48821155	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaagaagagagagaactgcTaaggtccacaacgtcggtga	17	5	12	7	2	0	4	0	1	0	3	2	6	1	4	1	2	3	1	1	2	6	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:48821155T>C	uc002isr.2	+	6	632	c.515T>C	c.(514-516)CTA>CCA	p.L172P	LUC7L3_uc002isp.1_Missense_Mutation_p.L96P|LUC7L3_uc010wmw.1_Missense_Mutation_p.L96P|LUC7L3_uc002isq.2_Missense_Mutation_p.L172P|LUC7L3_uc002iss.2_Missense_Mutation_p.L172P	NM_006107	NP_006098	O95232	LC7L3_HUMAN	LUC7-like 3	172	Potential.				apoptosis|mRNA processing|response to stress|RNA splicing	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding				0						AGAGAACTGCTAAGGTCCACA	0.363													9	48					0	0	0	0	C	48821155	C	C	48821155	3	2	19	1	0	0	0	0	1	0	0	0	9134	1522	53	5	537	5	LUC7L3	17	48821155	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	5594415	48821155	32374055	157	4355											
SMURF2	64750	broad.mit.edu	37	chr17	62579622	62579622	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttcttgttatatggtttaGatactggattcttccagagg	9	17	10	5	0	2	2	0	0	2	2	3	3	3	3	1	3	1	3	1	3	4	9			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:62579622G>C	uc002jep.1	-	7	914	c.526C>G	c.(526-528)CTA>GTA	p.L176V	SMURF2_uc002jeq.1_Translation_Start_Site|SMURF2_uc002jer.1_Translation_Start_Site	NM_022739	NP_073576	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	176	WW 1.				BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			ATATGGTTTAGATACTGGATT	0.413													4	85					0	0	0	0	C	62579622	C	C	62579622	3	2	19	1	0	0	0	0	1	0	0	0	14884	933	33	2	1772	2	SMURF2	17	62579622	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	13758467	62579622	18615588	158	4356											
CD300E	342510	broad.mit.edu	37	chr17	72619723	72619723	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccacagccccactcacctGagaggcagagaaggagtaga	14	3	12	12	0	1	3	1	1	0	3	1	6	1	4	4	2	2	2	4	2	2	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr17:72619723G>C	uc002jlb.1	-	1	79	c.38C>G	c.(37-39)TCA>TGA	p.S13*		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	13						integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						CCACTCACCTGAGAGGCAGAG	0.547													4	152					0	0	0	0	C	72619723	C	C	72619723	4	2	19	1	0	0	0	0	0	1	0	0	3013	1294	45	2	595	2	CD300E	17	72619723	Nonsense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	10040101	72619723	8575487	159	4357											
FHOD3	80206	broad.mit.edu	37	chr18	33935606	33935606	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggcttccaggatgacgcCgggtaagagcaactgttcac	11	7	13	10	2	1	2	1	1	0	1	2	4	2	3	2	3	2	4	2	3	3	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr18:33935606C>T	uc002kzt.1	+	2	367	c.270C>T	c.(268-270)GCC>GCT	p.A90A	FHOD3_uc002kzr.1_Silent_p.A90A|FHOD3_uc002kzs.1_Silent_p.A90A	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	90	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				AGGATGACGCCGGGTAAGAGC	0.542													15	13					0	0	0	0	T	33935606	T	T	33935606	2	4	19	1	0	0	0	0	0	0	0	1	5915	639	23	1		1	FHOD3	18	33935606	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08		33935606	44141642	160	4358											
SMAD2	4087	broad.mit.edu	37	chr18	45371798	45371798	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cggcttcaaaaccctgattaAcagactgagccagaagagca	15	6	9	11	1	1	5	1	2	0	3	1	5	1	5	2	1	4	2	2	1	4	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr18:45371798A>G	uc002lcy.2	-	10	1441	c.1193T>C	c.(1192-1194)GTT>GCT	p.V398A	SMAD2_uc002lcz.2_Missense_Mutation_p.V398A|SMAD2_uc010xdc.1_Missense_Mutation_p.V368A|SMAD2_uc010xdd.1_Missense_Mutation_p.V368A	NM_005901	NP_005892	Q15796	SMAD2_HUMAN	Sma- and Mad-related protein 2 isoform 1	398	MH2.			V->R: Increased binding to PPM1A.	anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			large_intestine(3)|lung(1)|central_nervous_system(1)	5						ACCCTGATTAACAGACTGAGC	0.383													49	42					0	0	0	0	G	45371798	G	G	45371798	3	3	19	1	0	0	0	0	1	0	0	0	14822	43	2	5	218	5	SMAD2	18	45371798	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	11436192	45371798	32705450	161	4359											
AP3D1	8943	broad.mit.edu	37	chr19	2121203	2121203	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtagttggactggctgcaGatgtcaatgatcttggtgag	8	13	15	5	0	2	3	1	2	1	1	2	4	2	4	0	4	1	4	0	4	2	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:2121203G>A	uc002luz.2	-	13	1432	c.1209C>T	c.(1207-1209)ATC>ATT	p.I403I	AP3D1_uc002luy.2_Silent_p.I312I|AP3D1_uc002lva.2_Silent_p.I403I	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	403	HEAT 8.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTGGCTGCAGATGTCAATGA	0.587													16	63					0	0	0	0	A	2121203	A	A	2121203	2	1	19	1	0	0	0	0	0	0	0	1	746	932	33	2		2	AP3D1	19	2121203	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08		2121203	57007780	162	4360											
DOT1L	84444	broad.mit.edu	37	chr19	2210666	2210666	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggagcagccaccgtgaagaAgccgtctccctccaaagccc	10	4	11	16	2	1	2	0	1	1	1	3	3	2	3	6	1	4	1	6	1	3	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:2210666A>T	uc002lvb.3	+	14	1199	c.1163A>T	c.(1162-1164)AAG>ATG	p.K388M	DOT1L_uc002lvc.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	388						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCGTGAAGAAGCCGTCTCCC	0.607													22	131					0	0	0	0	T	2210666	T	T	2210666	3	4	19	1	0	0	0	0	1	0	0	0	4731	72	3	5	1217	5	DOT1L	19	2210666	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	89463	2210666	56918317	163	4361											
DIRAS1	148252	broad.mit.edu	37	chr19	2717766	2717766	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgcccacgccgcccgccccGaacaccaccacgcggtaatc	8	4	8	21	6	0	0	0	0	0	0	1	1	0	0	7	1	2	1	7	1	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:2717766G>A	uc002lwf.3	-	2	197	c.39C>T	c.(37-39)TTC>TTT	p.F13F		NM_145173	NP_660156	O95057	DIRA1_HUMAN	DIRAS family, GTP-binding RAS-like 1	13					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCCGCCCCGAACACCACCA	0.547													9	30					0	0	0	0	A	2717766	A	A	2717766	2	1	19	1	0	0	0	0	0	0	0	1	4552	1049	37	1		1	DIRAS1	19	2717766	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08	507100	2717766	56411217	164	4362											
SLC44A2	57153	broad.mit.edu	37	chr19	10745462	10745462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgctacatggagtactcccGactgcgtggtgaggccggct	6	9	14	12	3	0	1	0	1	0	0	1	3	1	2	2	4	4	3	2	4	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:10745462G>A	uc002mpf.2	+	11	993	c.854G>A	c.(853-855)CGA>CAA	p.R285Q	SLC44A2_uc002mpe.3_Missense_Mutation_p.R283Q|SLC44A2_uc002mpg.1_Missense_Mutation_p.R5Q|SLC44A2_uc002mph.2_5'Flank	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	285	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GAGTACTCCCGACTGCGTGGT	0.557													4	97					0	0	0	0	A	10745462	A	A	10745462	3	1	19	1	0	0	0	0	1	0	0	0	14700	1058	37	1	931	1	SLC44A2	19	10745462	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	8027696	10745462	48383521	165	4363											
EMR3	84658	broad.mit.edu	37	chr19	14736338	14736338	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtcaggacccatcttgctgGaaagtgtgtatgtctcagac	10	11	11	9	0	3	1	2	0	2	1	4	3	3	3	1	2	1	2	1	2	2	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:14736338G>A	uc002mzi.3	-	15	2034	c.1886C>T	c.(1885-1887)TCC>TTC	p.S629F	EMR3_uc010dzp.2_Missense_Mutation_p.S577F|EMR3_uc010xnv.1_Missense_Mutation_p.S503F	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	629	Cytoplasmic (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						CATCTTGCTGGAAAGTGTGTA	0.393													17	95					0	0	0	0	A	14736338	A	A	14736338	3	1	19	1	0	0	0	0	1	0	0	0	5130	1174	41	2	80	2	EMR3	19	14736338	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	3990876	14736338	44392645	166	4364											
ZNF429	353088	broad.mit.edu	37	chr19	21720747	21720747	+	Missense_Mutation	SNP	C	A	A																															agaatgtgccaaagcttttaCccggtcttcaagacttactc																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:21720747C>A	uc002nqd.1	+	4	2029	c.1892C>A	c.(1891-1893)ACC>AAC	p.T631N	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	631	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AAAGCTTTTACCCGGTCTTCA	0.254													4	40					0.00198382	0.00211666	1	0	A	21720747	A	A	21720747	3	1	19	1	0	0	0	0	1	0	0	0	17969	507	18	4	1906	4	ZNF429	19	21720747	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	6984409	21720747	37408236	167	4365	9	2									
ZNF429	353088	broad.mit.edu	37	chr19	21720754	21720754	+	Silent	SNP	T	C	C																															gccaaagcttttacccggtcTtcaagacttactcaacataa																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:21720754T>C	uc002nqd.1	+	4	2036	c.1899T>C	c.(1897-1899)TCT>TCC	p.S633S	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	633	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TTACCCGGTCTTCAAGACTTA	0.234													4	36					0	0	0	0	C	21720754	C	C	21720754	2	2	19	1	0	0	0	0	0	0	0	1	17969	1596	56	5		5	ZNF429	19	21720754	Silent	SNP	T	TCGA-BA-6872-01A-11D-1870-08	7	21720754	37408229	168	4366	9	2									
C19orf40	91442	broad.mit.edu	37	chr19	33464412	33464412	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgcattctttatgtcaccGaagctgatttggtggcagga	8	13	12	8	1	2	1	1	1	1	0	2	3	2	2	1	3	2	4	1	3	2	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:33464412G>A	uc002nud.3	+	3	305	c.187G>A	c.(187-189)GAA>AAA	p.E63K	CCDC123_uc002nty.2_5'Flank|CCDC123_uc010edg.2_5'Flank|CCDC123_uc002ntz.1_5'Flank|CCDC123_uc002nua.2_5'Flank|CCDC123_uc002nuc.1_5'Flank	NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa	63					DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					TTATGTCACCGAAGCTGATTT	0.328								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks					19	106					0	0	0	0	A	33464412	A	A	33464412	3	1	19	1	0	0	0	0	1	0	0	0	1932	1059	37	1	193	1	C19orf40	19	33464412	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	11743658	33464412	25664571	169	4367											
ATP4A	495	broad.mit.edu	37	chr19	36051332	36051332	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggctctcgtgcgtgcactcGggtgagcgggtctgtggctc	2	10	18	11	4	2	1	0	1	2	0	5	1	2	1	0	4	3	3	0	4	0	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:36051332G>A	uc002oal.1	-	6	749	c.720C>T	c.(718-720)CCC>CCT	p.P240P	ATP4A_uc010eee.1_5'Flank	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	240	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GCGTGCACTCGGGTGAGCGGG	0.657													15	81					0	0	0	0	A	36051332	A	A	36051332	2	1	19	1	0	0	0	0	0	0	0	1	1147	1103	39	1		1	ATP4A	19	36051332	Silent	SNP	G	TCGA-BA-6872-01A-11D-1870-08	2586920	36051332	23077651	170	4368											
NUP62	23636	broad.mit.edu	37	chr19	50412137	50412137	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggccaggtggagcggtcaCggcagctgctgtattgctgg	6	8	18	9	2	1	0	1	0	0	0	1	1	1	1	1	6	4	5	1	6	1	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:50412137C>T	uc002pqx.2	-	2	1032	c.928G>A	c.(928-930)GTG>ATG	p.V310M	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.V310M|NUP62_uc002pqz.2_Missense_Mutation_p.V310M|NUP62_uc002pra.2_Missense_Mutation_p.V310M|NUP62_uc002prb.2_Missense_Mutation_p.V310M|NUP62_uc002prc.2_Intron	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	310	Ala-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GGAGCGGTCACGGCAGCTGCT	0.517													9	49					0	0	0	0	T	50412137	T	T	50412137	3	4	19	1	0	0	0	0	1	0	0	0	10822	536	19	1	644	1	NUP62	19	50412137	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	14360805	50412137	8716846	171	4369											
ZNF577	84765	broad.mit.edu	37	chr19	52376780	52376780	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcattcatgtggtttccCtcctgcacaaattttttgta	8	17	6	10	0	1	0	1	0	0	0	3	0	3	0	2	1	2	4	2	1	2	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:52376780C>G	uc010yde.1	-	7	854	c.463G>C	c.(463-465)GGG>CGG	p.G155R	ZNF577_uc010ydd.1_Intron|ZNF577_uc002pxx.3_Missense_Mutation_p.G96R|ZNF577_uc002pxv.2_Missense_Mutation_p.G148R|ZNF577_uc002pxw.2_Missense_Mutation_p.G89R	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGTGGTTTCCCTCCTGCACAA	0.448													7	120					0	0	0	0	G	52376780	G	G	52376780	3	3	19	1	0	0	0	0	1	0	0	0	18076	681	24	4	998	4	ZNF577	19	52376780	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	1964643	52376780	6752203	172	4370											
ZNF320	162967	broad.mit.edu	37	chr19	53384531	53384539	+	In_Frame_Del	DEL	GCGAAGGTC	-	-																															ttacgaggactgaatttcgaGcgaaggtcttgccacactca																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:53384531_53384539delGCGAAGGTC	uc002qag.2	-	4	1031_1039	c.840_848delGACCTTCGC	c.(838-849)AAGACCTTCGCT>AAT	p.280_283KTFA>N	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_In_Frame_Del_p.226_229KTFA>N|ZNF320_uc002qai.2_In_Frame_Del_p.280_283KTFA>N	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	280_283	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TGAATTTCGAGCGAAGGTCTTGCCACACT	0.416													---	---	---								-	53384539	-	-	53384531	7	5	19	1	0	1	0	1	0	0	0	0	17906	971	34	0	685	0	ZNF320	19	53384531	In_Frame_Del	DEL	GCGAAGGTC	TCGA-BA-6872-01A-11D-1870-08	1007751	53384531	5744452	173	4371											
MBOAT7	79143	broad.mit.edu	37	chr19	54677830	54677830	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacctaaagccagccccaGccccagggctgccagggcca	9	2	10	20	0	0	0	0	0	0	0	0	0	0	0	9	2	4	1	9	2	2	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:54677830G>T	uc002qdq.2	-	9	1593	c.1327C>A	c.(1327-1329)CTG>ATG	p.L443M	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Missense_Mutation_p.L127M|MBOAT7_uc010yem.1_Missense_Mutation_p.L425M|MBOAT7_uc002qdr.2_Missense_Mutation_p.L443M|MBOAT7_uc002qds.2_Missense_Mutation_p.L370M|MBOAT7_uc010yen.1_Missense_Mutation_p.L370M	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	443	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCAGCCCCAGCCCCAGGGCT	0.652													8	33					5.18039e-06	5.81274e-06	1	0	T	54677830	T	T	54677830	3	4	19	1	0	0	0	0	1	0	0	0	9411	962	34	4	95	4	MBOAT7	19	54677830	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1293299	54677830	4451153	174	4372											
PEG3	5178	broad.mit.edu	37	chr19	57327434	57327434	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttactgggccctgctacActgtgacttttctgagcttc	5	15	10	11	0	1	2	0	2	1	0	2	2	1	2	1	2	4	3	1	2	2	6			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:57327434A>C	uc002qnu.2	-	7	2727	c.2376T>G	c.(2374-2376)AGT>AGG	p.S792R	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.S763R|PEG3_uc002qnv.2_Missense_Mutation_p.S792R|PEG3_uc002qnw.2_Missense_Mutation_p.S668R|PEG3_uc002qnx.2_Missense_Mutation_p.S666R|PEG3_uc010etr.2_Missense_Mutation_p.S792R	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	792					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GCCCTGCTACACTGTGACTTT	0.453													76	88					0	0	0	0	C	57327434	C	C	57327434	3	2	19	1	0	0	0	0	1	0	0	0	11774	156	6	5	2394	5	PEG3	19	57327434	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08	2649604	57327434	1801549	175	4373											
ZBTB45	84878	broad.mit.edu	37	chr19	59028615	59028615	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgcgcaggtgcgagtggCgggggcacaggggtgggcag	6	4	23	8	3	0	0	0	0	0	0	0	1	0	0	0	7	3	4	0	7	0	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr19:59028615C>T	uc002qtd.2	-	2	718	c.426G>A	c.(424-426)CCG>CCA	p.P142P	ZBTB45_uc002qte.2_Silent_p.P142P|ZBTB45_uc002qtf.2_Silent_p.P142P	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	142	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		GTGCGAGTGGCGGGGGCACAG	0.706											OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	13					0	0	0	0	T	59028615	T	T	59028615	2	4	19	1	0	0	0	0	0	0	0	1	17613	755	27	1		1	ZBTB45	19	59028615	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	1701181	59028615	100368	176	4374											
PAK7	57144	broad.mit.edu	37	chr20	9561038	9561038	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttcactgtacgccaggctCtccttggagcacccgctggt	5	11	10	15	2	2	0	1	0	1	0	3	1	2	1	3	3	2	4	3	3	1	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr20:9561038C>G	uc002wnl.2	-	5	1289	c.744G>C	c.(742-744)GAG>GAC	p.E248D	PAK7_uc002wnk.2_Missense_Mutation_p.E248D|PAK7_uc002wnj.2_Missense_Mutation_p.E248D|PAK7_uc010gby.1_Missense_Mutation_p.E248D	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	248	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ACGCCAGGCTCTCCTTGGAGC	0.537													7	68					0	0	0	0	G	9561038	G	G	9561038	3	3	19	1	0	0	0	0	1	0	0	0	11459	912	32	2	1443	2	PAK7	20	9561038	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08		9561038	53464482	177	4375											
RBL1	5933	broad.mit.edu	37	chr20	35717460	35717460	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatgataccctttccaacCgtgggaataatgcttttgcg	9	13	8	11	2	0	1	0	1	0	0	2	2	2	2	4	1	4	1	4	1	4	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr20:35717460C>T	uc002xgi.2	-	2	301	c.222G>A	c.(220-222)ACG>ACA	p.T74T	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Silent_p.T74T|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	74					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				CCTTTCCAACCGTGGGAATAA	0.383													12	76					0	0	0	0	T	35717460	T	T	35717460	2	4	19	1	0	0	0	0	0	0	0	1	13174	639	23	1		1	RBL1	20	35717460	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	26156422	35717460	27308060	178	4376											
LBP	3929	broad.mit.edu	37	chr20	36992694	36992694	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaagcccctcgggcaacaGcccagatgctggaggtgatg	9	6	15	11	1	0	2	0	1	0	1	1	4	0	4	3	4	4	2	3	4	2	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr20:36992694G>T	uc002xic.1	+	7	753	c.718G>T	c.(718-720)GCC>TCC	p.A240S		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	240					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				TCGGGCAACAGCCCAGATGCT	0.562													6	44					0.00198382	0.00211666	1	0	T	36992694	T	T	36992694	3	4	19	1	0	0	0	0	1	0	0	0	8691	971	34	4	744	4	LBP	20	36992694	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1275234	36992694	26032826	179	4377											
B4GALT5	9334	broad.mit.edu	37	chr20	48263615	48263615	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttcaagtcaagaggataaTctagggaggtaaaggaaaaa	18	7	13	3	0	3	1	2	0	1	1	3	4	3	4	0	5	0	2	0	5	8	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr20:48263615T>C	uc002xuu.3	-	3	445	c.251A>G	c.(250-252)GAT>GGT	p.D84G		NM_004776	NP_004767	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	84	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			AAGAGGATAATCTAGGGAGGT	0.413													14	49					0	0	0	0	C	48263615	C	C	48263615	3	2	19	1	0	0	0	0	1	0	0	0	1276	1449	50	5	943	5	B4GALT5	20	48263615	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	11270921	48263615	14761905	180	4378											
MC3R	4159	broad.mit.edu	37	chr20	54823685	54823686	+	5'Flank	DEL	TC	-	-																															tctttctctctgtgtgtatgTctctctctctctctgtctct																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr20:54823685_54823686delTC	uc002xxb.2	+							NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor						activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			tgtgtgtatgtctctctctctc	0.208													---	---	---								-	54823686	-	-	54823685	6	5	19	0	1	1	0	1	0	0	0	0	9418	1682	58	0		0	MC3R	20	54823685	5'Flank	DEL	TC	TCGA-BA-6872-01A-11D-1870-08	6560070	54823685	8201835	181	4379											
PRPF6	24148	broad.mit.edu	37	chr20	62626765	62626765	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gccaggactgatgacacctgGcacaggtgagctggacatga	11	6	14	10	0	0	4	0	4	0	0	0	6	0	6	2	4	1	2	2	4	0	0			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr20:62626765G>T	uc002yho.2	+	6	869	c.701G>T	c.(700-702)GGC>GTC	p.G234V	PRPF6_uc002yhp.2_Missense_Mutation_p.G234V	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	234					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					ATGACACCTGGCACAGGTGAG	0.527													11	51					5.50884e-06	6.15239e-06	1	0	T	62626765	T	T	62626765	3	4	19	1	0	0	0	0	1	0	0	0	12636	1203	42	4	723	4	PRPF6	20	62626765	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	7803080	62626765	398755	182	4380											
ZNF295	49854	broad.mit.edu	37	chr21	43413679	43413679	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gactgcaatgctaggagaggGccgggaagtatggcttacat	11	8	15	7	1	0	1	0	0	0	1	0	4	0	2	1	4	3	4	1	4	5	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr21:43413679G>A	uc002zab.3	-	3	740	c.526C>T	c.(526-528)CCC>TCC	p.P176S	ZNF295_uc002yzz.3_Missense_Mutation_p.P176S|ZNF295_uc002yzy.3_Missense_Mutation_p.P176S|ZNF295_uc002zaa.3_Missense_Mutation_p.P176S|ZNF295_uc010gov.1_Missense_Mutation_p.P176S|ZNF295_uc002zac.2_Missense_Mutation_p.P176S	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	176					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CTAGGAGAGGGCCGGGAAGTA	0.418													41	132					0	0	0	0	A	43413679	A	A	43413679	3	1	19	1	0	0	0	0	1	0	0	0	17894	1203	42	4	2678	4	ZNF295	21	43413679	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08		43413679	4716216	183	4381											
KRTAP10-9	386676	broad.mit.edu	37	chr21	46047691	46047691	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccatctgctgtgtgcctgtCtgctctggggcttcctcttt	1	16	10	14	0	4	0	0	0	4	0	5	0	5	0	3	2	3	3	3	2	0	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr21:46047691C>G	uc002zfp.3	+	1	652	c.603C>G	c.(601-603)GTC>GTG	p.V201V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	201	20.|25 X 5 AA repeats of C-C-X(3).					keratin filament					0						GTGTGCCTGTCTGCTCTGGGG	0.622													72	296					0	0	0	0	G	46047691	G	G	46047691	2	3	19	1	0	0	0	0	0	0	0	1	8555	900	32	2		2	KRTAP10-9	21	46047691	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	2634012	46047691	2082204	184	4382											
PCNT	5116	broad.mit.edu	37	chr21	47783764	47783764	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	attgcagccagtgtgggcggGagccgcccacagcccaggac	8	4	15	14	2	0	0	0	0	0	0	0	2	0	2	4	3	4	1	4	3	0	1			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr21:47783764G>C	uc002zji.3	+	14	2631	c.2524G>C	c.(2524-2526)GAG>CAG	p.E842Q	PCNT_uc002zjj.2_Missense_Mutation_p.E724Q	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	842					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTGTGGGCGGGAGCCGCCCAC	0.662													8	129					0	0	0	0	C	47783764	C	C	47783764	3	2	19	1	0	0	0	0	1	0	0	0	11644	1175	41	2	2578	2	PCNT	21	47783764	Missense_Mutation	SNP	G	TCGA-BA-6872-01A-11D-1870-08	1736073	47783764	346131	185	4383											
MICAL3	57553	broad.mit.edu	37	chr22	18301236	18301236	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggttggcagggacaacggCtcgccttccggctttggcag	5	8	17	11	3	0	0	0	0	0	0	2	1	1	1	2	7	1	5	2	7	1	3			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr22:18301236C>T	uc002zng.3	-	26	4544	c.4191G>A	c.(4189-4191)GAG>GAA	p.E1397E	MICAL3_uc011agl.1_Silent_p.E1313E|MICAL3_uc010gre.1_5'Flank	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1397	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		GGGACAACGGCTCGCCTTCCG	0.647													34	94					0	0	0	0	T	18301236	T	T	18301236	2	4	19	1	0	0	0	0	0	0	0	1	9624	796	28	4		4	MICAL3	22	18301236	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08		18301236	33003330	186	4384											
CABIN1	23523	broad.mit.edu	37	chr22	24463127	24463127	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccagcccagctgcttcttCtgcaggtgtgtgctgccagt	4	11	13	13	0	2	0	0	0	2	0	2	0	2	0	3	2	6	4	3	2	0	2			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr22:24463127C>T	uc002zzi.1	+	16	2354	c.2227C>T	c.(2227-2229)CTG>TTG	p.L743L	CABIN1_uc002zzj.1_Silent_p.L693L|CABIN1_uc002zzl.1_Silent_p.L743L	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	743					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GCTGCTTCTTCTGCAGGTGTG	0.532													5	26					0	0	0	0	T	24463127	T	T	24463127	2	4	19	1	0	0	0	0	0	0	0	1	2540	912	32	2		2	CABIN1	22	24463127	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	6161891	24463127	26841439	187	4385											
SRRD	402055	broad.mit.edu	37	chr22	26886165	26886168	+	Splice_Site	DEL	GTAA	-	-																															ttcaaaggacttgaggagagGtaagtctgagaatgctgaga																										TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr22:26886165_26886168delGTAA	uc010gve.2	+	5	771	c.764_splice	c.e5+1	p.R255_splice	SRRD_uc003acp.3_Splice_Site_p.R248_splice|uc003acu.1_5'Flank	NM_001013694	NP_001013716	Q9UH36	SRR1L_HUMAN	SRR1 domain containing						rhythmic process						0						TTGAGGAGAGGTAAGTCTGAGAAT	0.461													---	---	---								-	26886168	-	-	26886165	8	5	19	1	0	1	0	1	0	0	1	0	15233	1275	44	0	783	0	SRRD	22	26886165	Splice_Site	DEL	GTAA	TCGA-BA-6872-01A-11D-1870-08	2423038	26886165	24418401	188	4386											
TPST2	8459	broad.mit.edu	37	chr22	26928676	26928676	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaacctgaaaatatcctttCagattggctggtgttttata	11	16	7	7	0	1	2	1	1	0	1	2	2	2	2	2	2	1	2	2	2	6	7			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr22:26928676C>T	uc003acv.2	-	4	1245	c.1077G>A	c.(1075-1077)CTG>CTA	p.L359L	TPST2_uc003acw.2_Silent_p.L359L|TPST2_uc003acx.2_Silent_p.L359L	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	359	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						AATATCCTTTCAGATTGGCTG	0.264													35	233					0	0	0	0	T	26928676	T	T	26928676	2	4	19	1	0	0	0	0	0	0	0	1	16495	813	29	2		2	TPST2	22	26928676	Silent	SNP	C	TCGA-BA-6872-01A-11D-1870-08	42511	26928676	24375890	189	4387											
SMC1B	27127	broad.mit.edu	37	chr22	45745620	45745620	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaacttactttgcctatgtTagtattgtctagggctgcat	9	16	9	7	0	1	0	0	0	1	0	1	1	1	0	1	1	4	4	1	1	6	7			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chr22:45745620T>A	uc003bgc.2	-	23	3536	c.3484A>T	c.(3484-3486)AAC>TAC	p.N1162Y	SMC1B_uc003bgd.2_Intron	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	1162					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TTGCCTATGTTAGTATTGTCT	0.333													17	26					0	0	0	0	A	45745620	A	A	45745620	3	1	19	1	0	0	0	0	1	0	0	0	14846	1754	61	5	235	5	SMC1B	22	45745620	Missense_Mutation	SNP	T	TCGA-BA-6872-01A-11D-1870-08	18816944	45745620	5558946	190	4388											
REPS2	9185	broad.mit.edu	37	chrX	17047658	17047658	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtttcagcaccttatgAagctaggcagccccttgtcc	7	12	9	13	0	1	1	1	1	0	0	2	1	2	1	4	1	4	5	4	1	3	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chrX:17047658A>G	uc004cxv.1	+	5	854	c.683A>G	c.(682-684)GAA>GGA	p.E228G	REPS2_uc004cxw.1_Missense_Mutation_p.E227G|REPS2_uc011miw.1_Missense_Mutation_p.E87G	NM_004726	NP_004717	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	228					epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					GCACCTTATGAAGCTAGGCAG	0.483													3	57					0	0	0	0	G	17047658	G	G	17047658	3	3	19	1	0	0	0	0	1	0	0	0	13294	246	9	5	701	5	REPS2	23	17047658	Missense_Mutation	SNP	A	TCGA-BA-6872-01A-11D-1870-08		17047658	138222902	191	4389											
CDKL5	6792	broad.mit.edu	37	chrX	18646534	18646534	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caagttgttacatctctcttCggcctcaaatcacccggctt	8	13	6	14	2	4	0	2	0	2	0	6	0	4	0	2	2	1	3	2	2	3	4			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chrX:18646534C>T	uc004cym.2	+	18	2793	c.2540C>T	c.(2539-2541)TCG>TTG	p.S847L	CDKL5_uc004cyn.2_Missense_Mutation_p.S847L	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	847					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					CATCTCTCTTCGGCCTCAAAT	0.483													63	93					0	0	0	0	T	18646534	T	T	18646534	3	4	19	1	0	0	0	0	1	0	0	0	3172	893	31	1	2606	1	CDKL5	23	18646534	Missense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	1598876	18646534	136624026	192	4390											
GABRQ	55879	broad.mit.edu	37	chrX	151818953	151818953	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagttaacagctaccttgtgCaagtctactggcctactgtc	10	12	8	11	0	1	0	0	0	1	0	2	0	1	0	2	1	6	3	2	1	6	5			TCGA-BA-6872-01A-11D-1870-08	TCGA-BA-6872-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	182b2a39-4881-402a-a907-b51aa114584a	1f4ec99a-77d9-437c-b7d0-d67a65109078	g.chrX:151818953C>T	uc004ffp.1	+	7	831	c.811C>T	c.(811-813)CAA>TAA	p.Q271*		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	271	Helical; (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTACCTTGTGCAAGTCTACTG	0.488													209	67					0	0	0	0	T	151818953	T	T	151818953	4	4	19	1	0	0	0	0	0	1	0	0	6209	711	25	4	837	4	GABRQ	23	151818953	Nonsense_Mutation	SNP	C	TCGA-BA-6872-01A-11D-1870-08	133172419	151818953	3451607	193	4391											
PER3	8863	broad.mit.edu	37	chr1	7902814	7902814	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctggtagaagacagctgttGagtgactgtgaggatgaacc	11	10	14	6	0	1	6	0	4	1	2	1	7	1	7	1	2	2	3	1	2	3	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:7902814G>C	uc001aoo.2	+	21	3780	c.3605G>C	c.(3604-3606)TGA>TCA	p.*1202S	PER3_uc001aop.2_Nonstop_Mutation_p.*1211S|PER3_uc010nzw.1_Nonstop_Mutation_p.*891S	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	1202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		GACAGCTGTTGAGTGACTGTG	0.438													24	77					0	0	0	0	C	7902814	C	C	7902814	4	2	20	1	0	0	0	0	0	0	0	0	11785	1285	45	2	3687	2	PER3	1	7902814	Nonstop_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08		7902814	241347807	1	4392											
EPHA2	1969	broad.mit.edu	37	chr1	16462185	16462185	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacctcgtacttccacactcGgctctgctgcggcgggggga	5	8	14	14	4	1	0	0	0	1	0	4	2	2	1	2	5	3	3	2	5	1	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:16462185G>A	uc001aya.1	-	6	1530	c.1393C>T	c.(1393-1395)CGA>TGA	p.R465*	EPHA2_uc010oca.1_Nonsense_Mutation_p.R465*	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	465	Extracellular (Potential).|Fibronectin type-III 2.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	TTCCACACTCGGCTCTGCTGC	0.662													35	36					0	0	0	0	A	16462185	A	A	16462185	4	1	20	1	0	0	0	0	0	1	0	0	5191	1124	39	1	1585	1	EPHA2	1	16462185	Nonsense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	8559371	16462185	232788436	2	4393											
KIAA0754	643314	broad.mit.edu	37	chr1	39879889	39879889	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttcagtgcccaccccagagGtgcctgccatcccagctgct	6	8	9	18	0	1	1	1	0	0	1	2	1	2	1	6	1	5	2	6	1	0	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:39879889G>A	uc009vvt.1	+	1	4714	c.3952G>A	c.(3952-3954)GTG>ATG	p.V1318M	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	1182	Ala-rich.										0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CACCCCAGAGGTGCCTGCCAT	0.627													6	37					0	0	0	0	A	39879889	A	A	39879889	3	1	20	1	0	0	0	0	1	0	0	0	8231	1261	44	4	3954	4	KIAA0754	1	39879889	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	23417704	39879889	209370732	3	4394											
PTPRF	5792	broad.mit.edu	37	chr1	44069439	44069439	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacaccatagatttcggcaaGgatgaccagcacttcacagt	14	8	8	11	1	1	2	1	1	0	1	2	3	1	3	2	2	2	2	2	2	3	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:44069439G>A	uc001cjr.2	+	16	2956	c.2616G>A	c.(2614-2616)AAG>AAA	p.K872K	PTPRF_uc001cjs.2_Silent_p.K863K|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Silent_p.K432K|PTPRF_uc001cjv.2_Silent_p.K332K|PTPRF_uc001cjw.2_Silent_p.K98K	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	872	Extracellular (Potential).|Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATTTCGGCAAGGATGACCAGC	0.632													18	89					0	0	0	0	A	44069439	A	A	44069439	2	1	20	1	0	0	0	0	0	0	0	1	12866	991	35	4		4	PTPRF	1	44069439	Silent	SNP	G	TCGA-BA-6873-01A-11D-1870-08	4189550	44069439	205181182	4	4395											
TAL1	6886	broad.mit.edu	37	chr1	47691450	47691450	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgcggctcgtctccttggcGacgccgttcagcaggaccag	5	7	14	15	6	2	0	1	0	1	0	4	2	2	1	3	3	1	3	3	3	0	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:47691450G>A	uc001cqx.2	-	2	688	c.111C>T	c.(109-111)GTC>GTT	p.V37V	TAL1_uc009vyq.2_5'Flank|TAL1_uc001cqy.2_Silent_p.V37V|TAL1_uc001cra.1_Intron|TAL1_uc001cqz.1_Intron	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	37					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1						TCTCCTTGGCGACGCCGTTCA	0.562			T	TRD@|SIL	lymphoblastic leukemia/biphasic								11	27					0	0	0	0	A	47691450	A	A	47691450	2	1	20	1	0	0	0	0	0	0	0	1	15607	1045	37	1		1	TAL1	1	47691450	Silent	SNP	G	TCGA-BA-6873-01A-11D-1870-08	3622011	47691450	201559171	5	4396											
SGIP1	84251	broad.mit.edu	37	chr1	67105475	67105475	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tacagaagaaaagcaatgggGcaccaaatggattttatgcg	16	8	11	6	1	0	2	0	0	0	2	0	3	0	3	1	3	3	2	1	3	7	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:67105475G>A	uc001dcr.2	+	5	404	c.187G>A	c.(187-189)GCA>ACA	p.A63T		NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	63					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						AAGCAATGGGGCACCAAATGG	0.289													14	53					0	0	0	0	A	67105475	A	A	67105475	3	1	20	1	0	0	0	0	1	0	0	0	14271	1203	42	4	205	4	SGIP1	1	67105475	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	19414025	67105475	182145146	6	4397											
PSRC1	84722	broad.mit.edu	37	chr1	109824422	109824422	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcacaaaggtctcccgcCgaggactgggcttcactcgg	8	7	12	14	3	3	0	2	0	1	0	5	2	3	1	2	4	1	2	2	4	1	1	rs114022452	byFrequency	TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:109824422C>T	uc001dxg.2	-	4	460	c.338G>A	c.(337-339)CGG>CAG	p.R113Q	PSRC1_uc001dxb.2_5'UTR|PSRC1_uc001dxc.2_Missense_Mutation_p.R113Q|PSRC1_uc001dxd.2_Missense_Mutation_p.R113Q|PSRC1_uc001dxe.2_Missense_Mutation_p.R113Q|PSRC1_uc001dxf.2_Missense_Mutation_p.R113Q|PSRC1_uc001dxh.2_Missense_Mutation_p.R113Q|PSRC1_uc001dxi.2_Missense_Mutation_p.R113Q|PSRC1_uc001dxj.2_Missense_Mutation_p.R113Q	NM_001032290	NP_001027461	Q6PGN9	PSRC1_HUMAN	proline/serine-rich coiled-coil 1 isoform c	113	4 X 4 AA repeats of P-X-X-P.				cell division|microtubule bundle formation|mitotic metaphase plate congression|negative regulation of cell growth|positive regulation of microtubule polymerization|positive regulation of transcription, DNA-dependent|regulation of mitotic spindle organization	cytosol|midbody|spindle pole	microtubule binding				0		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0286)|Lung(183;0.0658)|COAD - Colon adenocarcinoma(174;0.112)|Epithelial(280;0.188)|all cancers(265;0.213)		GGTCTCCCGCCGAGGACTGGG	0.672													32	53					0	0	0	0	T	109824422	T	T	109824422	3	4	20	1	0	0	0	0	1	0	0	0	12781	652	23	1	744	1	PSRC1	1	109824422	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	42718947	109824422	139426199	7	4398											
NTRK1	4914	broad.mit.edu	37	chr1	156845368	156845368	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtccctgcatttcatgacaTtgggtggcagctccctgtcc	5	13	10	13	0	1	1	1	1	0	0	4	1	4	1	3	2	2	3	3	2	0	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:156845368T>C	uc001fqh.1	+	12	1467	c.1411T>C	c.(1411-1413)TTG>CTG	p.L471L	NTRK1_uc001fqf.1_Silent_p.L435L|NTRK1_uc009wsi.1_Silent_p.L170L|NTRK1_uc001fqi.1_Silent_p.L465L|NTRK1_uc009wsk.1_Silent_p.L465L	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	471	Cytoplasmic (Potential).|Interaction with SQSTM1 (By similarity).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TTTCATGACATTGGGTGGCAG	0.607			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			15	78					0	0	0	0	C	156845368	C	C	156845368	2	2	20	1	0	0	0	0	0	0	0	1	10760	1490	52	5		5	NTRK1	1	156845368	Silent	SNP	T	TCGA-BA-6873-01A-11D-1870-08	47020946	156845368	92405253	8	4399											
HHIPL2	79802	broad.mit.edu	37	chr1	222696022	222696022	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttttcaggctcttcctcCtcttgccctggcggacgtgg	2	13	12	14	2	3	0	1	0	2	0	5	1	5	1	3	5	1	2	3	5	0	4			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:222696022C>T	uc001hnh.1	-	9	2154	c.2096G>A	c.(2095-2097)AGG>AAG	p.R699K		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	699					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GCTCTTCCTCCTCTTGCCCTG	0.567													103	269					0	0	0	0	T	222696022	T	T	222696022	3	4	20	1	0	0	0	0	1	0	0	0	7133	681	24	4	82	4	HHIPL2	1	222696022	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	65850654	222696022	26554599	9	4400											
HHIPL2	79802	broad.mit.edu	37	chr1	222721186	222721186	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgtgctgatcacagcagccGaaggactcatagtcagagca	12	8	11	10	1	3	2	3	1	0	1	3	4	3	3	1	1	4	3	1	1	2	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:222721186G>A	uc001hnh.1	-	1	259	c.201C>T	c.(199-201)TTC>TTT	p.F67F		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	67					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CACAGCAGCCGAAGGACTCAT	0.567													23	40					0	0	0	0	A	222721186	A	A	222721186	2	1	20	1	0	0	0	0	0	0	0	1	7133	1049	37	1		1	HHIPL2	1	222721186	Silent	SNP	G	TCGA-BA-6873-01A-11D-1870-08	25164	222721186	26529435	10	4401											
OR2M4	26245	broad.mit.edu	37	chr1	248402849	248402849	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcatttgttgtgtggtaatgCtaatctttccagtttcagtt	7	20	8	6	0	3	0	2	0	1	0	4	0	4	0	1	1	1	5	1	1	2	7			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr1:248402849C>T	uc010pzh.1	+	1	619	c.619C>T	c.(619-621)CTA>TTA	p.L207L		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGTGGTAATGCTAATCTTTCC	0.433													12	78					0	0	0	0	T	248402849	T	T	248402849	2	4	20	1	0	0	0	0	0	0	0	1	11066	796	28	4		4	OR2M4	1	248402849	Silent	SNP	C	TCGA-BA-6873-01A-11D-1870-08	25681663	248402849	847772	11	4402											
PSME4	23198	broad.mit.edu	37	chr2	54120868	54120868	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccttttctgtcttctaaTgatagaaaagtaattaactg	12	18	5	6	0	3	2	0	1	3	1	4	2	4	2	1	0	1	1	1	0	6	8			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr2:54120868T>C	uc002rxp.2	-	35	4037	c.3981A>G	c.(3979-3981)TCA>TCG	p.S1327S	PSME4_uc010yop.1_Silent_p.S1213S|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Silent_p.S702S|PSME4_uc010fbv.1_Silent_p.S471S	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1327					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TGTCTTCTAATGATAGAAAAG	0.289													8	30					0	0	0	0	C	54120868	C	C	54120868	2	2	20	1	0	0	0	0	0	0	0	1	12771	1451	51	5		5	PSME4	2	54120868	Silent	SNP	T	TCGA-BA-6873-01A-11D-1870-08		54120868	189078505	12	4403											
TFCP2L1	29842	broad.mit.edu	37	chr2	121981961	121981961	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtagccatcattgctctCagctgcaagagagaaacact	12	9	10	10	0	2	2	2	0	1	2	3	3	2	2	1	1	5	4	1	1	3	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr2:121981961C>T	uc002tmx.2	-	15	1489	c.1396G>A	c.(1396-1398)GAG>AAG	p.E466K	TFCP2L1_uc010flr.2_Missense_Mutation_p.E401K|TFCP2L1_uc010flq.2_RNA	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	466					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					TCATTGCTCTCAGCTGCAAGA	0.517													17	32					0	0	0	0	T	121981961	T	T	121981961	3	4	20	1	0	0	0	0	1	0	0	0	15862	835	29	2	47	2	TFCP2L1	2	121981961	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	67861093	121981961	121217412	13	4404											
GPR155	151556	broad.mit.edu	37	chr2	175301127	175301127	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccacagaaagttccagcaGaagtctttgcaccacacctg	13	7	8	13	0	1	2	0	0	1	2	2	2	2	2	4	0	3	3	4	0	2	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr2:175301127G>A	uc002uit.2	-	17	2721	c.2330C>T	c.(2329-2331)TCT>TTT	p.S777F	GPR155_uc002uiu.2_Missense_Mutation_p.S777F|GPR155_uc002uiv.2_Missense_Mutation_p.S777F|GPR155_uc010fqs.2_Missense_Mutation_p.S749F	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	777	DEP.				intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						AGTTCCAGCAGAAGTCTTTGC	0.473													33	62					0	0	0	0	A	175301127	A	A	175301127	3	1	20	1	0	0	0	0	1	0	0	0	6698	942	33	2	286	2	GPR155	2	175301127	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	53319166	175301127	67898246	14	4405											
HOXD13	3239	broad.mit.edu	37	chr2	176958165	176958165	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcagcgtaccggccaacgagGtgccagcgcgagccaaggag	10	2	16	13	5	0	0	0	0	0	0	0	3	0	1	4	3	6	2	4	3	3	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr2:176958165G>T	uc002ukf.1	+	1	634	c.547G>T	c.(547-549)GTG>TTG	p.V183L		NM_000523	NP_000514	P35453	HXD13_HUMAN	homeobox D13	183					skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		GGCCAACGAGGTGCCAGCGCG	0.627			T	NUP98	AML*								12	53					0.00010058	0.000104603	1	0	T	176958165	T	T	176958165	3	4	20	1	0	0	0	0	1	0	0	0	7361	1261	44	4	549	4	HOXD13	2	176958165	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	1657038	176958165	66241208	15	4406											
CASP8	841	broad.mit.edu	37	chr2	202131411	202131411	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgaaggagctgctcttcCgaattaatagactggatttg	10	13	10	8	1	1	2	0	1	1	1	3	5	3	4	2	2	2	2	2	2	4	4			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr2:202131411C>T	uc002uxr.1	+	3	411	c.202C>T	c.(202-204)CGA>TGA	p.R68*	CASP8_uc010ftc.1_Nonsense_Mutation_p.R68*|CASP8_uc002uxo.1_Nonsense_Mutation_p.R68*|CASP8_uc002uxp.1_Nonsense_Mutation_p.R68*|CASP8_uc002uxq.1_Nonsense_Mutation_p.R68*|CASP8_uc002uxs.1_Nonsense_Mutation_p.R68*|CASP8_uc002uxt.1_Nonsense_Mutation_p.R127*|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Nonsense_Mutation_p.R68*|CASP8_uc002uxw.1_Nonsense_Mutation_p.R68*|CASP8_uc002uxy.1_Nonsense_Mutation_p.R68*|CASP8_uc002uxx.1_Nonsense_Mutation_p.R68*|CASP8_uc010ftf.2_Nonsense_Mutation_p.R68*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	68	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GCTGCTCTTCCGAATTAATAG	0.453										HNSCC(4;0.00038)			16	49					0	0	0	0	T	202131411	T	T	202131411	4	4	20	1	0	0	0	0	0	1	0	0	2689	644	23	1	385	1	CASP8	2	202131411	Nonsense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	25173246	202131411	41067962	16	4407											
IDH1	3417	broad.mit.edu	37	chr2	209108281	209108281	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaactgtgtgcaaaatcttCaattgacttatcttgattat	12	16	7	6	0	3	2	1	2	2	0	3	3	3	3	0	1	2	1	0	1	6	5			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr2:209108281C>T	uc002vcs.2	-	6	814	c.568G>A	c.(568-570)GAA>AAA	p.E190K	IDH1_uc002vct.2_Missense_Mutation_p.E190K|IDH1_uc002vcu.2_Missense_Mutation_p.E190K	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	190					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		GCAAAATCTTCAATTGACTTA	0.408			Mis		gliobastoma 								28	40					0	0	0	0	T	209108281	T	T	209108281	3	4	20	1	0	0	0	0	1	0	0	0	7533	835	29	2	696	2	IDH1	2	209108281	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	6976870	209108281	34091092	17	4408											
LRRFIP2	9209	broad.mit.edu	37	chr3	37095356	37095356	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttttcctactgctgggccaGaagtgctgtcctattggcct	5	14	11	11	0	0	1	0	0	0	1	2	1	2	1	4	2	3	3	4	2	3	5			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr3:37095356G>C	uc003cgp.2	-	29	2575	c.2152C>G	c.(2152-2154)CTG>GTG	p.L718V	MLH1_uc011aye.1_Intron|LRRFIP2_uc011ayf.1_Missense_Mutation_p.L500V|LRRFIP2_uc003cgr.2_Missense_Mutation_p.L421V|LRRFIP2_uc003cgs.3_Missense_Mutation_p.L421V|LRRFIP2_uc003cgt.3_Missense_Mutation_p.L397V	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	718					Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1						TGCTGGGCCAGAAGTGCTGTC	0.532													36	77					0	0	0	0	C	37095356	C	C	37095356	3	2	20	1	0	0	0	0	1	0	0	0	9078	933	33	2	17	2	LRRFIP2	3	37095356	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08		37095356	160927074	18	4409											
KIAA1524	57650	broad.mit.edu	37	chr3	108288376	108288376	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagagtggcgctgccaggtgGagactgttcaaacatcatct	10	9	12	10	1	3	2	2	0	1	2	3	3	3	2	1	3	2	2	1	3	1	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr3:108288376G>T	uc003dxb.3	-	9	1242	c.973C>A	c.(973-975)CCA>ACA	p.P325T	KIAA1524_uc010hpv.1_5'Flank|KIAA1524_uc003dxc.1_Missense_Mutation_p.P166T|KIAA1524_uc010hpw.1_Missense_Mutation_p.P166T	NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	325						cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						CTGCCAGGTGGAGACTGTTCA	0.458													6	25					1.06961e-07	1.1351e-07	1	0	T	108288376	T	T	108288376	3	4	20	1	0	0	0	0	1	0	0	0	8278	1174	41	2	1796	2	KIAA1524	3	108288376	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	71193020	108288376	89734054	19	4410											
PARP14	54625	broad.mit.edu	37	chr3	122418601	122418602	+	Frame_Shift_Ins	INS	-	A	A																															tcaggtctaaatataaagtcINSaacccaattaaagtggatcc																										TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr3:122418601_122418602insA	uc003efq.3	+	6	1259_1260	c.1200_1201insA	c.(1198-1203)GTCAACfs	p.V400fs	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Frame_Shift_Ins_p.V117fs|PARP14_uc003efs.1_Frame_Shift_Ins_p.V117fs	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	400_401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		AATATAAAGTCAACCCAATTAA	0.406													---	---	---								A	122418602	A	A	122418601	7	5	20	1	0	1	1	0	0	0	0	0	11512	813	29	0	1222	0	PARP14	3	122418601	Frame_Shift_Ins	INS	-	TCGA-BA-6873-01A-11D-1870-08	14130225	122418601	75603829	20	4411											
PLSCR4	57088	broad.mit.edu	37	chr3	145912935	145912935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaagcaagctccaaaaatCatggctttcatcttcacatc	14	10	6	11	0	4	0	3	0	1	0	6	1	5	1	1	2	2	3	1	2	4	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr3:145912935C>T	uc010huy.2	-	8	1250	c.921G>A	c.(919-921)ATG>ATA	p.M307I	PLSCR4_uc010huz.2_Missense_Mutation_p.M307I|PLSCR4_uc003evt.3_Missense_Mutation_p.M307I|PLSCR4_uc010hva.2_Missense_Mutation_p.M217I|PLSCR4_uc003evu.3_Missense_Mutation_p.M202I	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	307	Helical; (Potential).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						CTCCAAAAATCATGGCTTTCA	0.353													6	49					0	0	0	0	T	145912935	T	T	145912935	3	4	20	1	0	0	0	0	1	0	0	0	12167	826	29	2	76	2	PLSCR4	3	145912935	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	23494334	145912935	52109495	21	4412											
MED12L	116931	broad.mit.edu	37	chr3	151082800	151082800	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagtaaagcaaaccatataTaataacgtgatgcctgcaaa	20	8	6	7	1	0	1	0	1	0	0	0	1	0	1	2	0	5	3	2	0	9	5			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr3:151082800T>C	uc003eyp.2	+	20	2924	c.2886T>C	c.(2884-2886)TAT>TAC	p.Y962Y	MED12L_uc011bnz.1_Silent_p.Y822Y|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Silent_p.Y125Y	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	962					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAACCATATATAATAACGTGA	0.353													68	246					0	0	0	0	C	151082800	C	C	151082800	2	2	20	1	0	0	0	0	0	0	0	1	9482	1413	49	5		5	MED12L	3	151082800	Silent	SNP	T	TCGA-BA-6873-01A-11D-1870-08	5169865	151082800	46939630	22	4413											
ENPEP	2028	broad.mit.edu	37	chr4	111441470	111441470	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaagaacatcacacagaaaCgctttttgttggacccaaga	15	9	7	10	1	2	3	2	0	0	3	2	4	2	4	1	1	2	2	1	1	4	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr4:111441470C>T	uc003iab.3	+	10	2017	c.1675C>T	c.(1675-1677)CGC>TGC	p.R559C		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	559	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CACACAGAAACGCTTTTTGTT	0.448													34	30					0	0	0	0	T	111441470	T	T	111441470	3	4	20	1	0	0	0	0	1	0	0	0	5152	536	19	1	1713	1	ENPEP	4	111441470	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08		111441470	79712806	23	4414											
FAT1	2195	broad.mit.edu	37	chr4	187539564	187539564	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtcccactatgttctgctcGgatgagatctatctctgttc	7	15	8	11	1	3	1	0	1	3	1	7	3	4	2	1	1	1	3	1	1	2	4			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr4:187539564G>A	uc003izf.2	-	10	8364	c.8176C>T	c.(8176-8178)CGA>TGA	p.R2726*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2726	Extracellular (Potential).|Cadherin 25.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGTTCTGCTCGGATGAGATCT	0.453										HNSCC(5;0.00058)			70	65					0	0	0	0	A	187539564	A	A	187539564	4	1	20	1	0	0	0	0	0	1	0	0	5721	1124	39	1	5662	1	FAT1	4	187539564	Nonsense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	76098094	187539564	3614712	24	4415											
CEP72	55722	broad.mit.edu	37	chr5	637680	637680	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcagaagttggatttgtCaggagaaatggtgcctggtc	9	13	13	6	0	2	2	2	0	1	2	4	4	2	3	1	4	1	1	1	4	2	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr5:637680C>G	uc003jbf.2	+	7	1025	c.953C>G	c.(952-954)TCA>TGA	p.S318*	CEP72_uc011clz.1_RNA	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	318					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			TTGGATTTGTCAGGAGAAATG	0.552													15	108					0	0	0	0	G	637680	G	G	637680	4	3	20	1	0	0	0	0	0	1	0	0	3275	838	29	2	979	2	CEP72	5	637680	Nonsense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08		637680	180277580	25	4416											
DHX29	54505	broad.mit.edu	37	chr5	54603304	54603304	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcttgctttgggcctccccgGcaattccagcctcggcagat	5	11	10	15	2	1	1	0	0	1	1	4	1	3	1	5	3	2	3	5	3	1	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr5:54603304G>A	uc003jpx.2	-	1	218	c.98C>T	c.(97-99)GCC>GTC	p.A33V	SKIV2L2_uc003jpy.3_5'Flank|SKIV2L2_uc011cqi.1_5'Flank|DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	33	Ala-rich.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GGCCTCCCCGGCAATTCCAGC	0.662													41	157					0	0	0	0	A	54603304	A	A	54603304	3	1	20	1	0	0	0	0	1	0	0	0	4525	1203	42	4	4119	4	DHX29	5	54603304	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	53965624	54603304	126311956	26	4417											
KIF4B	285643	broad.mit.edu	37	chr5	154394891	154394891	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctgcagccattgatactgCggtagaagaagaagctcaag	13	7	13	8	1	1	4	1	1	0	3	1	4	1	4	1	2	5	4	1	2	6	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr5:154394891C>T	uc010jih.1	+	1	1632	c.1472C>T	c.(1471-1473)GCG>GTG	p.A491V		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	491	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATTGATACTGCGGTAGAAGAA	0.443													16	114					0	0	0	0	T	154394891	T	T	154394891	3	4	20	1	0	0	0	0	1	0	0	0	8343	768	27	1	1474	1	KIF4B	5	154394891	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	99791587	154394891	26520369	27	4418											
ZNF454	285676	broad.mit.edu	37	chr5	178369801	178369801	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaagaaagaatggctgtCagccacctgccaaccatggt	13	6	12	10	0	1	3	1	0	0	3	1	4	1	3	4	3	3	1	4	3	4	0			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr5:178369801C>A	uc003mjo.1	+	2	280	c.9C>A	c.(7-9)GTC>GTA	p.V3V	ZNF454_uc010jkz.1_Silent_p.V3V|ZNF454_uc003mjp.2_Missense_Mutation_p.Q39K	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		GAATGGCTGTCAGCCACCTGC	0.537													7	65					5.18039e-06	5.44203e-06	1	0	A	178369801	A	A	178369801	2	1	20	1	0	0	0	0	0	0	0	1	17990	813	29	2		2	ZNF454	5	178369801	Silent	SNP	C	TCGA-BA-6873-01A-11D-1870-08	23974910	178369801	2545459	28	4419											
BTNL8	79908	broad.mit.edu	37	chr5	180335650	180335650	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggggaggacgcagcattCtcctgtttcctgtctcctaa	6	12	12	11	1	2	0	0	0	2	0	5	2	3	2	3	3	1	3	3	3	1	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr5:180335650C>A	uc003mmp.2	+	2	348	c.114C>A	c.(112-114)TTC>TTA	p.F38L	BTNL8_uc003mmq.2_Missense_Mutation_p.F38L|BTNL8_uc011dhg.1_Intron|BTNL8_uc010jll.2_Missense_Mutation_p.F38L|BTNL8_uc010jlm.2_Intron|BTNL8_uc011dhh.1_5'Flank	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	38	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACGCAGCATTCTCCTGTTTCC	0.552													37	70					2.47872e-24	2.77191e-24	1	0	A	180335650	A	A	180335650	3	1	20	1	0	0	0	0	1	0	0	0	1572	912	32	2	146	2	BTNL8	5	180335650	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	1965849	180335650	579610	29	4420											
RREB1	6239	broad.mit.edu	37	chr6	7230732	7230732	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtgcagcgccgcgttcgcGgccaagcgcaactgcatcca	8	5	13	15	6	0	0	0	0	0	0	2	1	1	0	3	1	5	4	3	1	2	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr6:7230732G>A	uc003mxc.2	+	10	2790	c.2400G>A	c.(2398-2400)GCG>GCA	p.A800A	RREB1_uc003mxb.2_Silent_p.A800A|RREB1_uc010jnx.2_Silent_p.A800A	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	800	C2H2-type 11.				multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CCGCGTTCGCGGCCAAGCGCA	0.711													4	19					0	0	0	0	A	7230732	A	A	7230732	2	1	20	1	0	0	0	0	0	0	0	1	13744	1103	39	1		1	RREB1	6	7230732	Silent	SNP	G	TCGA-BA-6873-01A-11D-1870-08		7230732	163884335	30	4421											
TAAR2	9287	broad.mit.edu	37	chr6	132938773	132938773	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacaagcaaccaagatgtcaTagccctctattccatctgca	14	9	5	13	0	3	1	1	0	2	1	4	1	4	1	3	0	5	2	3	0	6	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr6:132938773T>G	uc003qdl.1	-	2	572	c.572A>C	c.(571-573)TAT>TCT	p.Y191S	TAAR2_uc010kfr.1_Missense_Mutation_p.Y146S	NM_001033080	NP_001028252	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2 isoform 1	191	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		CAAGATGTCATAGCCCTCTAT	0.493													8	80					0	0	0	0	G	132938773	G	G	132938773	3	3	20	1	0	0	0	0	1	0	0	0	15556	1406	49	5	487	5	TAAR2	6	132938773	Missense_Mutation	SNP	T	TCGA-BA-6873-01A-11D-1870-08	125708041	132938773	38176294	31	4422											
ABCA13	154664	broad.mit.edu	37	chr7	48314202	48314202	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actccttaatgcctgtagttCatcacactagtccacaaaat	13	12	4	12	0	2	0	2	0	0	0	4	0	4	0	3	0	1	2	3	0	5	4			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr7:48314202C>T	uc003toq.2	+	17	4964	c.4939C>T	c.(4939-4941)CAT>TAT	p.H1647Y	ABCA13_uc010kyr.2_Missense_Mutation_p.H1150Y	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1647					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GCCTGTAGTTCATCACACTAG	0.373													60	137					0	0	0	0	T	48314202	T	T	48314202	3	4	20	1	0	0	0	0	1	0	0	0	31	826	29	2	4834	2	ABCA13	7	48314202	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08		48314202	110824461	32	4423											
WBSCR17	64409	broad.mit.edu	37	chr7	70885987	70885987	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggacaactttgaggtgcaGcggtacgagaactcggccca	11	6	13	11	3	0	2	0	1	0	1	1	4	0	3	1	4	5	2	1	4	3	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr7:70885987G>T	uc003tvy.2	+	5	858	c.858G>T	c.(856-858)CAG>CAT	p.Q286H	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	286	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TTGAGGTGCAGCGGTACGAGA	0.582													37	133					1.90571e-15	2.06452e-15	1	0	T	70885987	T	T	70885987	3	4	20	1	0	0	0	0	1	0	0	0	17332	962	34	4	876	4	WBSCR17	7	70885987	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	22571785	70885987	88252676	33	4424											
PCLO	27445	broad.mit.edu	37	chr7	82785646	82785646	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagaccaggttgagctggaCgcccagggtccgggggtctt	6	8	17	10	2	1	2	0	2	1	1	2	4	2	3	3	5	1	2	3	5	0	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr7:82785646C>T	uc003uhx.2	-	2	600	c.311G>A	c.(310-312)CGT>CAT	p.R104H	PCLO_uc003uhv.2_Missense_Mutation_p.R104H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	104					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTGAGCTGGACGCCCAGGGTC	0.428													9	43					0	0	0	0	T	82785646	T	T	82785646	3	4	20	1	0	0	0	0	1	0	0	0	11637	536	19	1	15230	1	PCLO	7	82785646	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	11899659	82785646	76353017	34	4425											
CSMD1	64478	broad.mit.edu	37	chr8	3565950	3565950	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcacagacagagtttttaTggcttccatccttgctgggc	8	13	9	11	0	1	2	1	0	0	2	3	2	3	2	2	2	1	3	2	2	1	5			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr8:3565950T>C	uc011kwk.1	-	7	1385	c.995A>G	c.(994-996)CAT>CGT	p.H332R		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	332	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGAGTTTTTATGGCTTCCATC	0.463													18	32					0	0	0	0	C	3565950	C	C	3565950	3	2	20	1	0	0	0	0	1	0	0	0	3961	1464	51	5	9768	5	CSMD1	8	3565950	Missense_Mutation	SNP	T	TCGA-BA-6873-01A-11D-1870-08		3565950	142798072	35	4426											
TTPA	7274	broad.mit.edu	37	chr8	63973923	63973923	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttcaccaccatattccagaGgaagaatgtctgggaaatgc	13	9	9	10	0	2	2	1	0	1	2	3	4	3	4	3	2	1	0	3	2	4	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr8:63973923G>A	uc003xux.1	-	5	757	c.725C>T	c.(724-726)CCT>CTT	p.P242L		NM_000370	NP_000361	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	242	CRAL-TRIO.				lipid metabolic process		transporter activity|vitamin E binding				0	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)	ATATTCCAGAGGAAGAATGTC	0.393													8	74					0	0	0	0	A	63973923	A	A	63973923	3	1	20	1	0	0	0	0	1	0	0	0	16804	1000	35	4	115	4	TTPA	8	63973923	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	60407973	63973923	82390099	36	4427											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			24	8					0	0	0	0	A	21971120	A	A	21971120	4	1	20	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08		21971120	119242311	37	4428											
OR13C8	138802	broad.mit.edu	37	chr9	107332319	107332319	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggagtgatgactcccatgCttaatcctctcatctatagt	10	14	7	10	0	2	2	1	2	2	0	5	3	4	3	2	1	1	1	2	1	3	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr9:107332319C>A	uc011lvo.1	+	1	871	c.871C>A	c.(871-873)CTT>ATT	p.L291I		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	291	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GACTCCCATGCTTAATCCTCT	0.408													20	68					8.04996e-18	8.81258e-18	1	0	A	107332319	A	A	107332319	3	1	20	1	0	0	0	0	1	0	0	0	10992	797	28	4	873	4	OR13C8	9	107332319	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	85361199	107332319	33881112	38	4429											
NOTCH1	4851	broad.mit.edu	37	chr9	139412704	139412704	+	Frame_Shift_Del	DEL	G	-	-																															cagttggagccctcgttacaGgggttgctgatgcatgcgtc																										TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr9:139412704delG	uc004chz.2	-	7	1140	c.1140delC	c.(1138-1140)CCCfs	p.P380fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	380	Extracellular (Potential).|EGF-like 10.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCTCGTTACAGGGGTTGCTGA	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								-	139412704	-	-	139412704	7	5	20	1	0	1	0	1	0	0	0	0	10601	987	35	0	6639	0	NOTCH1	9	139412704	Frame_Shift_Del	DEL	G	TCGA-BA-6873-01A-11D-1870-08	32080385	139412704	1800727	39	4430											
CCAR1	55749	broad.mit.edu	37	chr10	70525798	70525798	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtctttgagtgtcctattgGactacagattagaggataat	11	15	10	5	0	1	3	0	1	1	2	2	5	2	5	1	2	1	0	1	2	4	6			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr10:70525798G>C	uc001joo.2	+	17	2379	c.2260G>C	c.(2260-2262)GAC>CAC	p.D754H	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Missense_Mutation_p.D559H|CCAR1_uc009xpx.1_Missense_Mutation_p.D728H|CCAR1_uc001jon.1_Missense_Mutation_p.D700H|CCAR1_uc010qiz.1_Missense_Mutation_p.D739H|CCAR1_uc010qja.1_Missense_Mutation_p.D739H|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	754	Glu-rich.				apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						TGTCCTATTGGACTACAGATT	0.274													19	53					0	0	0	0	C	70525798	C	C	70525798	3	2	20	1	0	0	0	0	1	0	0	0	2742	1174	41	2	2322	2	CCAR1	10	70525798	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08		70525798	65008949	40	4431											
HELLS	3070	broad.mit.edu	37	chr10	96336456	96336456	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatggaacccaggaggaacGtcaaaaattggtaagaaata	18	7	10	6	1	2	1	2	0	0	1	2	4	2	4	1	4	2	1	1	4	7	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr10:96336456G>A	uc001kjt.2	+	10	1031	c.926G>A	c.(925-927)CGT>CAT	p.R309H	HELLS_uc001kjs.2_Missense_Mutation_p.R293H|HELLS_uc009xul.2_Missense_Mutation_p.R309H|HELLS_uc009xum.2_Missense_Mutation_p.R309H|HELLS_uc009xun.2_Missense_Mutation_p.R185H|HELLS_uc009xuo.2_Missense_Mutation_p.R309H|HELLS_uc001kju.2_5'UTR|HELLS_uc009xup.2_RNA|HELLS_uc009xuq.2_Missense_Mutation_p.R171H|HELLS_uc009xur.2_RNA	NM_018063	NP_060533	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	309	Helicase ATP-binding.				cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		CAGGAGGAACGTCAAAAATTG	0.333													5	38					0	0	0	0	A	96336456	A	A	96336456	3	1	20	1	0	0	0	0	1	0	0	0	7085	1145	40	1	964	1	HELLS	10	96336456	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	25810658	96336456	39198291	41	4432											
SORCS3	22986	broad.mit.edu	37	chr10	106907398	106907398	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcacatcatcagtacagaCgagaaccaagtatttgctgc	14	9	8	10	1	2	2	2	0	0	2	2	3	2	2	1	0	5	4	1	0	4	3	rs147429425	by1000genomes	TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr10:106907398C>T	uc001kyi.1	+	9	1553	c.1326C>T	c.(1324-1326)GAC>GAT	p.D442D		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	442	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCAGTACAGACGAGAACCAAG	0.473													19	58					0	0	0	0	T	106907398	T	T	106907398	2	4	20	1	0	0	0	0	0	0	0	1	14996	535	19	1		1	SORCS3	10	106907398	Silent	SNP	C	TCGA-BA-6873-01A-11D-1870-08	10570942	106907398	28627349	42	4433											
VAX1	11023	broad.mit.edu	37	chr10	118896029	118896029	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcgagctcggtcctctcgCggcccaccacgtactggcag	5	6	14	16	5	1	0	0	0	1	0	4	1	2	0	3	4	2	3	3	4	1	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr10:118896029C>T	uc009xyx.2	-	2	628	c.383G>A	c.(382-384)CGC>CAC	p.R128H	VAX1_uc001ldb.1_Missense_Mutation_p.R128H	NM_001112704	NP_001106175	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1 isoform a	128	Homeobox.					nucleus	sequence-specific DNA binding			ovary(2)	2				all cancers(201;0.0108)		GGTCCTCTCGCGGCCCACCAC	0.667													15	40					0	0	0	0	T	118896029	T	T	118896029	3	4	20	1	0	0	0	0	1	0	0	0	17202	768	27	1	769	1	VAX1	10	118896029	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	11988631	118896029	16638718	43	4434											
CTBP2	1488	broad.mit.edu	37	chr10	126678151	126678151	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggttgggagagggcgctTgggaaggatgtgccactgtc	6	9	19	7	1	0	1	0	0	0	1	1	4	0	3	1	5	1	3	1	5	1	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr10:126678151T>C	uc009yak.2	-	11	1561	c.1274A>G	c.(1273-1275)CAA>CGA	p.Q425R	CTBP2_uc009yal.2_Missense_Mutation_p.Q425R|CTBP2_uc001lif.3_Missense_Mutation_p.Q425R|CTBP2_uc001lih.3_Missense_Mutation_p.Q425R|CTBP2_uc001lid.3_Missense_Mutation_p.Q493R|CTBP2_uc001lie.3_Missense_Mutation_p.Q965R	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	425					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		AGAGGGCGCTTGGGAAGGATG	0.567													4	116					0	0	0	0	C	126678151	C	C	126678151	3	2	20	1	0	0	0	0	1	0	0	0	4015	1812	63	5	67	5	CTBP2	10	126678151	Missense_Mutation	SNP	T	TCGA-BA-6873-01A-11D-1870-08	7782122	126678151	8856596	44	4435											
ADRBK1	156	broad.mit.edu	37	chr11	67044804	67044804	+	Frame_Shift_Del	DEL	T	-	-																															aggtgacctttgagaagatcTtttcccagaagctgggtgag																										TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr11:67044804delT	uc009yrn.1	+	2	441	c.175delT	c.(175-177)TTTfs	p.F59fs	ADRBK1_uc009yrm.1_Frame_Shift_Del_p.F59fs	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	59	RGS.|N-terminal.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	TGAGAAGATCTTTTCCCAGAA	0.607													---	---	---								-	67044804	-	-	67044804	7	5	20	1	0	1	0	1	0	0	0	0	343	1609	56	0	181	0	ADRBK1	11	67044804	Frame_Shift_Del	DEL	T	TCGA-BA-6873-01A-11D-1870-08		67044804	67961712	45	4436											
FOLH1B	219595	broad.mit.edu	37	chr11	89395322	89395322	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatttttttttttcagaataCgcttataggcatggaattgc	11	18	7	5	1	1	1	1	0	0	1	1	2	1	2	0	2	2	2	0	2	6	9			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr11:89395322C>T	uc001pda.2	+	2	433	c.-93C>T	c.(-95--91)TACGC>TATGC			NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TTTCAGAATACGCTTATAGGC	0.328													5	56					0	0	0	0	T	89395322	T	T	89395322	1	4	20	1	0	0	0	0	0	0	0	0	6012	551	19	1		1	FOLH1B	11	89395322	Translation_Start_Site	SNP	C	TCGA-BA-6873-01A-11D-1870-08	22350518	89395322	45611194	46	4437											
GPR162	27239	broad.mit.edu	37	chr12	6935885	6935885	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tacccctcgggaaccaggctCcttcctgcacaagtggtcat	8	9	9	15	1	1	0	1	0	0	0	4	1	3	1	5	3	3	2	5	3	3	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr12:6935885C>T	uc001qqw.1	+	5	1818	c.1283C>T	c.(1282-1284)TCC>TTC	p.S428F	LEPREL2_uc001qqz.1_5'Flank|LEPREL2_uc001qra.1_5'Flank|LEPREL2_uc001qrb.1_5'Flank|GPR162_uc001qqx.1_Missense_Mutation_p.S144F|GPR162_uc009zfd.1_Missense_Mutation_p.S124F|GPR162_uc001qqy.1_Intron	NM_019858	NP_062832	Q16538	GP162_HUMAN	G protein-coupled receptor 162 isoform 2	428	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GAACCAGGCTCCTTCCTGCAC	0.612													86	143					0	0	0	0	T	6935885	T	T	6935885	3	4	20	1	0	0	0	0	1	0	0	0	6704	855	30	2	1316	2	GPR162	12	6935885	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08		6935885	126916010	47	4438											
ACCN2	41	broad.mit.edu	37	chr12	50475373	50475373	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accctgccgggatgacatacGctgccaacatcctacctcac	10	7	7	17	2	1	1	1	1	0	0	2	2	2	2	5	1	5	1	5	1	3	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr12:50475373G>A	uc001rvw.2	+	12	1757	c.1528G>A	c.(1528-1530)GCT>ACT	p.A510T	ACCN2_uc001rvv.2_Missense_Mutation_p.A556T|ACCN2_uc009zln.2_Missense_Mutation_p.A301T|ACCN2_uc009zlo.2_Missense_Mutation_p.A510T	NM_001095	NP_001086	P78348	ACCN2_HUMAN	amiloride-sensitive cation channel 2, neuronal	510	Cytoplasmic (By similarity).				calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)	GATGACATACGCTGCCAACAT	0.642													5	48					0	0	0	0	A	50475373	A	A	50475373	3	1	20	1	0	0	0	0	1	0	0	0	129	1087	38	1	1708	1	ACCN2	12	50475373	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	43539488	50475373	83376522	48	4439											
BEST3	144453	broad.mit.edu	37	chr12	70049468	70049468	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctcctgtagcttcttcttCtggggctggaggggtgttcg	2	14	15	10	1	3	0	0	0	3	0	5	1	4	1	2	5	1	4	2	5	1	5			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr12:70049468C>G	uc001svg.2	-	10	1453	c.1226G>C	c.(1225-1227)AGA>ACA	p.R409T	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.R196T|BEST3_uc010stm.1_Missense_Mutation_p.R303T	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	409	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GCTTCTTCTTCTGGGGCTGGA	0.552													65	102					0	0	0	0	G	70049468	G	G	70049468	3	3	20	1	0	0	0	0	1	0	0	0	1408	913	32	2	784	2	BEST3	12	70049468	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	19574095	70049468	63802427	49	4440											
ATXN2	6311	broad.mit.edu	37	chr12	111895024	111895024	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagttgcccttacctgaacAggactgggtgcaggatgact	9	10	13	9	0	0	3	0	3	0	0	0	5	0	5	2	3	4	2	2	3	2	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr12:111895024A>G	uc001tsj.2	-	22	3672	c.3510T>C	c.(3508-3510)CCT>CCC	p.P1170P	ATXN2_uc001tsh.2_Silent_p.P905P|ATXN2_uc001tsi.2_Silent_p.P863P|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Silent_p.P358P|ATXN2_uc001tsl.1_Silent_p.P171P	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	1170					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						TTACCTGAACAGGACTGGGTG	0.537													3	40					0	0	0	0	G	111895024	G	G	111895024	2	3	20	1	0	0	0	0	0	0	0	1	1213	175	7	5		5	ATXN2	12	111895024	Silent	SNP	A	TCGA-BA-6873-01A-11D-1870-08	41845556	111895024	21956871	50	4441											
OASL	8638	broad.mit.edu	37	chr12	121465598	121465598	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagagggggcagattggctCtgggggacctggctttcaca	8	8	17	8	0	2	2	1	0	1	2	2	4	2	3	1	6	0	3	1	6	0	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr12:121465598C>T	uc001tzj.1	-	4	686	c.680G>A	c.(679-681)AGA>AAA	p.R227K	OASL_uc001tzk.1_Intron	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	227					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAGATTGGCTCTGGGGGACCT	0.398													25	39					0	0	0	0	T	121465598	T	T	121465598	3	4	20	1	0	0	0	0	1	0	0	0	10856	913	32	2	876	2	OASL	12	121465598	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	9570574	121465598	12386297	51	4442											
DCT	1638	broad.mit.edu	37	chr13	95112446	95112446	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcacttgagaatccagagTcccatctgctttatcaaacc	12	11	5	13	0	3	2	2	1	1	2	5	3	5	2	3	0	2	1	3	0	3	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr13:95112446T>C	uc001vlv.3	-	6	1505	c.1078A>G	c.(1078-1080)ACT>GCT	p.T360A	DCT_uc010afh.2_Missense_Mutation_p.T360A	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	360	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		GAATCCAGAGTCCCATCTGCT	0.408													8	26					0	0	0	0	C	95112446	C	C	95112446	3	2	20	1	0	0	0	0	1	0	0	0	4321	1667	58	5	600	5	DCT	13	95112446	Missense_Mutation	SNP	T	TCGA-BA-6873-01A-11D-1870-08		95112446	20057432	52	4443											
NPAS3	64067	broad.mit.edu	37	chr14	34269100	34269100	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggacagccgcgacagcgaCgacagcttcgagcactcgga	10	3	13	15	7	0	0	0	0	0	0	2	6	0	2	2	2	4	2	2	2	0	1	rs148867285		TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr14:34269100C>T	uc001wru.2	+	12	1651	c.1587C>T	c.(1585-1587)GAC>GAT	p.D529D	NPAS3_uc001wrs.2_Silent_p.D516D|NPAS3_uc001wrt.2_Silent_p.D497D|NPAS3_uc001wrv.2_Silent_p.D499D	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	529					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GCGACAGCGACGACAGCTTCG	0.637													27	43					0	0	0	0	T	34269100	T	T	34269100	2	4	20	1	0	0	0	0	0	0	0	1	10618	535	19	1		1	NPAS3	14	34269100	Silent	SNP	C	TCGA-BA-6873-01A-11D-1870-08		34269100	73080440	53	4444											
PAPLN	89932	broad.mit.edu	37	chr14	73721248	73721248	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagttgtggcgttggcgtcCggaagcggagcgttacttgc	5	11	16	9	5	1	0	1	0	0	0	2	2	2	2	1	4	4	3	1	4	2	4	rs143213374		TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr14:73721248C>T	uc010ttx.1	+	12	1493	c.1330C>T	c.(1330-1332)CGG>TGG	p.R444W	PAPLN_uc001xnw.3_Missense_Mutation_p.R417W|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.R444W	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	444	TSP type-1 4.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CGTTGGCGTCCGGAAGCGGAG	0.622													58	211					0	0	0	0	T	73721248	T	T	73721248	3	4	20	1	0	0	0	0	1	0	0	0	11482	643	23	1	1291	1	PAPLN	14	73721248	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	39452148	73721248	33628292	54	4445											
TRAF3	7187	broad.mit.edu	37	chr14	103357700	103357700	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcccacgaggccagctcCgccgtgcagcacgtcaacct	9	4	11	17	4	1	0	1	0	0	0	2	1	2	0	5	2	4	3	5	2	2	0			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr14:103357700C>T	uc001ymc.1	+	9	1118	c.765C>T	c.(763-765)TCC>TCT	p.S255S	TRAF3_uc001yme.1_Silent_p.S230S|TRAF3_uc001ymd.1_Silent_p.S255S|TRAF3_uc010txy.1_Intron	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	255					apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		AGGCCAGCTCCGCCGTGCAGC	0.557													7	35					0	0	0	0	T	103357700	T	T	103357700	2	4	20	1	0	0	0	0	0	0	0	1	16506	639	23	1		1	TRAF3	14	103357700	Silent	SNP	C	TCGA-BA-6873-01A-11D-1870-08	29636452	103357700	3991840	55	4446											
LCAT	3931	broad.mit.edu	37	chr16	67974104	67974112	+	In_Frame_Del	DEL	GCCCACGCC	-	-																															taggtgcggggcgtgggcagGcccacgccgtaaagacagta																								rs112299487		TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr16:67974104_67974112delGCCCACGCC	uc002euy.1	-	6	1029_1037	c.1018_1026delGGCGTGGGC	c.(1018-1026)GGCGTGGGCdel	p.GVG340del		NM_000229	NP_000220	P04180	LCAT_HUMAN	lecithin-cholesterol acyltransferase precursor	340_342					cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|reverse cholesterol transport|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein A-I binding|phosphatidylcholine-sterol O-acyltransferase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00418)|Epithelial(162;0.0183)|all cancers(182;0.12)		GCGTGGGCAGGCCCACGCCGTAAAGACAG	0.608													---	---	---								-	67974112	-	-	67974104	7	5	20	1	0	1	0	1	0	0	0	0	8698	1190	42	0	300	0	LCAT	16	67974104	In_Frame_Del	DEL	GCCCACGCC	TCGA-BA-6873-01A-11D-1870-08		67974104	22380649	56	4447											
NFAT5	10725	broad.mit.edu	37	chr16	69727514	69727515	+	Frame_Shift_Del	DEL	CT	-	-																															atagttgccatgcagagtaaCtctccatcccaggaacagca																								rs148486602		TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr16:69727514_69727515delCT	uc002exm.1	+	12	4940_4941	c.3732_3733delCT	c.(3730-3735)AACTCTfs	p.N1244fs	NFAT5_uc002exi.2_Frame_Shift_Del_p.N1168fs|NFAT5_uc002exj.1_Frame_Shift_Del_p.N1168fs|NFAT5_uc002exk.1_Frame_Shift_Del_p.N1168fs|NFAT5_uc002exl.1_Frame_Shift_Del_p.N1262fs|NFAT5_uc002exn.1_Frame_Shift_Del_p.N1261fs|NFAT5_uc002exo.1_RNA	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	1244_1245					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TGCAGAGTAACTCTCCATCCCA	0.361													---	---	---								-	69727515	-	-	69727514	7	5	20	1	0	1	0	1	0	0	0	0	10414	564	20	0	3836	0	NFAT5	16	69727514	Frame_Shift_Del	DEL	CT	TCGA-BA-6873-01A-11D-1870-08	1753410	69727514	20627239	57	4448											
ATP2A3	489	broad.mit.edu	37	chr17	3851149	3851149	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcccgatgtgatattggtgcCctggccaggggagggacaag	8	7	17	9	1	0	1	0	1	0	0	0	4	0	3	3	5	1	0	3	5	2	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr17:3851149C>T	uc002fxb.1	-	8	782	c.631G>A	c.(631-633)GGC>AGC	p.G211S	ATP2A3_uc002fwx.1_Missense_Mutation_p.G211S|ATP2A3_uc002fwy.1_Missense_Mutation_p.G211S|ATP2A3_uc002fwz.1_Missense_Mutation_p.G211S|ATP2A3_uc002fxa.1_Missense_Mutation_p.G211S|ATP2A3_uc002fxc.1_Missense_Mutation_p.G211S|ATP2A3_uc002fxd.1_Missense_Mutation_p.G211S	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	211	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		ATATTGGTGCCCTGGCCAGGG	0.607													6	36					0	0	0	0	T	3851149	T	T	3851149	3	4	20	1	0	0	0	0	1	0	0	0	1140	637	22	4	2635	4	ATP2A3	17	3851149	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08		3851149	77344061	58	4449											
TP53	7157	broad.mit.edu	37	chr17	7578271	7578271	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccttccactcggataagaTgctgaggaggggccagacct	9	9	12	11	1	0	3	0	1	0	2	3	5	2	5	4	4	1	1	4	4	1	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr17:7578271T>A	uc002gim.2	-	6	772	c.578A>T	c.(577-579)CAT>CTT	p.H193L	TP53_uc002gig.1_Missense_Mutation_p.H193L|TP53_uc002gih.2_Missense_Mutation_p.H193L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H61L|TP53_uc010cng.1_Missense_Mutation_p.H61L|TP53_uc002gii.1_Missense_Mutation_p.H61L|TP53_uc010cnh.1_Missense_Mutation_p.H193L|TP53_uc010cni.1_Missense_Mutation_p.H193L|TP53_uc002gij.2_Missense_Mutation_p.H193L|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100L|TP53_uc002gio.2_Missense_Mutation_p.H61L|TP53_uc010vug.1_Missense_Mutation_p.H154L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	193	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> D (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(67)|p.H193L(31)|p.H193Y(26)|p.H193P(12)|p.0?(7)|p.H193D(7)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.H193H(2)|p.P191fs*53(2)|p.K164_P219del(1)|p.P191fs*15(1)|p.P191fs*6(1)|p.H100L(1)|p.H61L(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	29					0	0	0	0	A	7578271	A	A	7578271	3	1	20	1	0	0	0	0	1	0	0	0	16448	1464	51	5	716	5	TP53	17	7578271	Missense_Mutation	SNP	T	TCGA-BA-6873-01A-11D-1870-08	3727122	7578271	73616939	59	4450											
TP53	7157	broad.mit.edu	37	chr17	7578384	7578401	+	In_Frame_Del	DEL	GCAGCGCTCATGGTGGGG	-	-																															tgctcaccatcgctatctgaGcagcgctcatggtgggggca																								rs138525931	by1000genomes	TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr17:7578384_7578401delGCAGCGCTCATGGTGGGG	uc002gim.2	-	5	723_740	c.529_546delCCCCACCATGAGCGCTGC	c.(529-546)CCCCACCATGAGCGCTGCdel	p.PHHERC177del	TP53_uc002gig.1_In_Frame_Del_p.PHHERC177del|TP53_uc002gih.2_In_Frame_Del_p.PHHERC177del|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.PHHERC45del|TP53_uc010cng.1_In_Frame_Del_p.PHHERC45del|TP53_uc002gii.1_In_Frame_Del_p.PHHERC45del|TP53_uc010cnh.1_In_Frame_Del_p.PHHERC177del|TP53_uc010cni.1_In_Frame_Del_p.PHHERC177del|TP53_uc002gij.2_In_Frame_Del_p.PHHERC177del|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_In_Frame_Del_p.PHHERC84del|TP53_uc002gio.2_In_Frame_Del_p.PHHERC45del|TP53_uc010vug.1_In_Frame_Del_p.PHHERC138del	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	177_182	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(98)|p.H179Y(74)|p.H179L(31)|p.R181H(20)|p.H179Q(17)|p.P177L(17)|p.P177R(15)|p.R181P(14)|p.H179N(13)|p.E180*(13)|p.R181C(13)|p.H178fs*69(10)|p.H179D(10)|p.P177P(10)|p.H178Y(8)|p.P177_C182delPHHERC(8)|p.P177S(8)|p.C182S(8)|p.0?(7)|p.H178P(6)|p.E180K(5)|p.H178fs*3(5)|p.H178Q(5)|p.C182*(5)|p.H178D(4)|p.C176_R181delCPHHER(3)|p.H179P(3)|p.H178N(3)|p.P177H(3)|p.E180D(3)|p.R175_E180delRCPHHE(3)|p.R181L(3)|p.R174fs*24(3)|p.H179fs*68(2)|p.H179H(2)|p.R174fs*1(2)|p.H178H(2)|p.P177fs*3(2)|p.C182Y(2)|p.C182C(2)|p.C182R(2)|p.R181R(2)|p.V173fs*59(2)|p.V173fs*69(1)|p.R175_H178>X(1)|p.E180G(1)|p.E180fs*67(1)|p.E180Q(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.H178fs*6(1)|p.H178L(1)|p.R174fs*3(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.P177fs*4(1)|p.H168fs*69(1)|p.E180>DGRCPHQ(1)|p.H178del(1)|p.P177I(1)|p.E180_S183del(1)|p.P177T(1)|p.K164_P219del(1)|p.R49P(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.C176_P177delCP(1)|p.P177fs*69(1)|p.R42fs*24(1)|p.R88P(1)|p.C182fs*4(1)|p.R174_E180>K(1)|p.P177_E180delPHHE(1)|p.C182fs*65(1)|p.C176fs*65(1)|p.R181G(1)|p.C176fs*68(1)|p.R174_H178>S(1)|p.R181>XXXXXXX(1)|p.H178_H179>QY(1)|p.?(1)|p.R81fs*24(1)|p.P177_H179delPHH(1)|p.E180fs*6(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGCTATCTGAGCAGCGCTCATGGTGGGGGCAGCGCCTC	0.638		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578401	-	-	7578384	7	5	20	1	0	1	0	1	0	0	0	0	16448	963	34	0	752	0	TP53	17	7578384	In_Frame_Del	DEL	GCAGCGCTCATGGTGGGG	TCGA-BA-6873-01A-11D-1870-08	113	7578384	73616826	60	4451											
CCDC144A	9720	broad.mit.edu	37	chr17	16631037	16631038	+	Frame_Shift_Del	DEL	AG	-	-																															caaaaaattgaatgggagaaAgagctgtacgatttgaggta																										TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr17:16631037_16631038delAG	uc002gqk.1	+	9	2164_2165	c.2088_2089delAG	c.(2086-2091)AAAGAGfs	p.K696fs	CCDC144A_uc002gql.1_Frame_Shift_Del_p.K166fs|LOC162632_uc010cpj.1_RNA	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	696_697	Potential.										0						AATGGGAGAAAGAGCTGTACGA	0.302													---	---	---								-	16631038	-	-	16631037	7	5	20	1	0	1	0	1	0	0	0	0	2789	69	3	0	2122	0	CCDC144A	17	16631037	Frame_Shift_Del	DEL	AG	TCGA-BA-6873-01A-11D-1870-08	9052653	16631037	64564173	61	4452											
PTPRM	5797	broad.mit.edu	37	chr18	7926657	7926657	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgccatcggcaggaccgtGgcaggagacaggctctggtt	8	7	16	10	2	1	1	0	0	1	1	2	3	1	2	2	6	1	4	2	6	0	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr18:7926657G>A	uc002knn.3	+	5	1142	c.639G>A	c.(637-639)GTG>GTA	p.V213V	PTPRM_uc010dkv.2_Silent_p.V213V	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	213	Ig-like C2-type.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GCAGGACCGTGGCAGGAGACA	0.522													9	97					0	0	0	0	A	7926657	A	A	7926657	2	1	20	1	0	0	0	0	0	0	0	1	12871	1335	47	4		4	PTPRM	18	7926657	Silent	SNP	G	TCGA-BA-6873-01A-11D-1870-08		7926657	70150591	62	4453											
WDR18	57418	broad.mit.edu	37	chr19	989771	989771	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccctcacaggtctccaccGggaaccttctggtcatcctg	6	9	9	17	1	4	0	2	0	2	0	6	1	5	1	6	3	1	0	6	3	1	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr19:989771G>A	uc002lqm.1	+	3	357	c.331G>A	c.(331-333)GGG>AGG	p.G111R	WDR18_uc002lqn.1_RNA|WDR18_uc010drx.1_Missense_Mutation_p.G74R|WDR18_uc010dry.1_Missense_Mutation_p.G111R	NM_024100	NP_077005	Q9BV38	WDR18_HUMAN	WD repeat domain 18	111	WD 2.									skin(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCTCCACCGGGAACCTTCT	0.632													18	79					0	0	0	0	A	989771	A	A	989771	3	1	20	1	0	0	0	0	1	0	0	0	17346	1116	39	1	341	1	WDR18	19	989771	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08		989771	58139212	63	4454											
ZNF426	79088	broad.mit.edu	37	chr19	9643595	9643595	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagactgggtttgatgatcTgacctcctgagcacagagaa	11	11	11	8	0	1	6	0	4	1	2	2	7	2	6	2	1	1	2	2	1	2	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr19:9643595T>A	uc002mlq.2	-	6	515	c.251A>T	c.(250-252)CAG>CTG	p.Q84L	ZNF426_uc010dws.2_Missense_Mutation_p.Q46L	NM_024106	NP_077011	Q9BUY5	ZN426_HUMAN	zinc finger protein 426	84	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTTGATGATCTGACCTCCTGA	0.413													24	119					0	0	0	0	A	9643595	A	A	9643595	3	1	20	1	0	0	0	0	1	0	0	0	17967	1580	55	5	1425	5	ZNF426	19	9643595	Missense_Mutation	SNP	T	TCGA-BA-6873-01A-11D-1870-08	8653824	9643595	49485388	64	4455											
ZSWIM4	65249	broad.mit.edu	37	chr19	13941278	13941278	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaccagatcgtgctggacgCggcggccggcggcctgggcc	4	5	17	15	6	0	1	0	0	0	1	1	2	0	2	4	6	2	1	4	6	1	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr19:13941278C>T	uc002mxh.1	+	13	2573	c.2384C>T	c.(2383-2385)GCG>GTG	p.A795V	ZSWIM4_uc010xng.1_Missense_Mutation_p.A718V	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	795							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			GTGCTGGACGCGGCGGCCGGC	0.697													64	81					0	0	0	0	T	13941278	T	T	13941278	3	4	20	1	0	0	0	0	1	0	0	0	18310	768	27	1	2434	1	ZSWIM4	19	13941278	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	4297683	13941278	45187705	65	4456											
ZNF507	22847	broad.mit.edu	37	chr19	32844652	32844652	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtggggtcgatgcagtcGtcattgctattggagagagt	7	12	16	6	2	1	1	1	0	0	1	3	4	1	2	0	4	2	2	0	4	1	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr19:32844652G>A	uc002nte.2	+	3	1188	c.916G>A	c.(916-918)GTC>ATC	p.V306I	ZNF507_uc002ntc.2_Missense_Mutation_p.V306I|ZNF507_uc010xrn.1_Missense_Mutation_p.V306I|ZNF507_uc002ntd.2_Missense_Mutation_p.V306I	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					CGATGCAGTCGTCATTGCTAT	0.478													19	177					0	0	0	0	A	32844652	A	A	32844652	3	1	20	1	0	0	0	0	1	0	0	0	18020	1145	40	1	918	1	ZNF507	19	32844652	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	18903374	32844652	26284331	66	4457											
BCKDHA	593	broad.mit.edu	37	chr19	41920002	41920002	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtgaggagggcacgcacGtggggagtgccgccgccctg	6	5	19	11	4	0	1	0	1	0	0	0	3	0	3	3	5	1	2	3	5	0	0			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr19:41920002G>A	uc002oqq.2	+	4	453	c.424G>A	c.(424-426)GTG>ATG	p.V142M	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Missense_Mutation_p.V176M|BCKDHA_uc002oqp.1_Missense_Mutation_p.V34M|BCKDHA_uc002oqr.2_Missense_Mutation_p.V142M|BCKDHA_uc010xvz.1_Missense_Mutation_p.V120M	NM_000709	NP_000700	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha	142					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding				0						GGGCACGCACGTGGGGAGTGC	0.617													16	83					0	0	0	0	A	41920002	A	A	41920002	3	1	20	1	0	0	0	0	1	0	0	0	1361	1145	40	1	438	1	BCKDHA	19	41920002	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	9075350	41920002	17208981	67	4458											
ERF	2077	broad.mit.edu	37	chr19	42754040	42754040	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtttgttgaaattgaacttGtaggtgaaccgtttcccctt	9	16	9	7	1	0	3	0	3	0	0	1	3	1	3	3	1	2	4	3	1	4	7			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr19:42754040G>A	uc002ote.3	-	3	470	c.312C>T	c.(310-312)TAC>TAT	p.Y104Y	ERF_uc002otd.3_5'UTR	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	104	ETS.				cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)				AATTGAACTTGTAGGTGAACC	0.488													30	134					0	0	0	0	A	42754040	A	A	42754040	2	1	20	1	0	0	0	0	0	0	0	1	5245	1372	48	4		4	ERF	19	42754040	Silent	SNP	G	TCGA-BA-6873-01A-11D-1870-08	834038	42754040	16374943	68	4459											
NLRP2	55655	broad.mit.edu	37	chr19	55489152	55489152	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaacgaccacctctagacGtggacgaaatgctggagcgc	13	5	12	11	4	1	2	0	0	1	2	1	6	1	4	2	2	3	1	2	2	4	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr19:55489152G>A	uc002qij.2	+	4	444	c.358G>A	c.(358-360)GTG>ATG	p.V120M	NLRP2_uc010yfp.1_Missense_Mutation_p.V97M|NLRP2_uc010esn.2_Intron|NLRP2_uc010eso.2_Missense_Mutation_p.V120M|NLRP2_uc010esp.2_Missense_Mutation_p.V120M	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	120					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ACCTCTAGACGTGGACGAAAT	0.542													31	62					0	0	0	0	A	55489152	A	A	55489152	3	1	20	1	0	0	0	0	1	0	0	0	10531	1145	40	1	368	1	NLRP2	19	55489152	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	12735112	55489152	3639831	69	4460											
C20orf46	55321	broad.mit.edu	37	chr20	1161909	1161909	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaagccataatccacCgggcggctcacgggctccag	12	4	11	14	3	1	0	1	0	0	0	3	1	3	0	4	3	2	2	4	3	3	1	rs139413230		TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr20:1161909C>T	uc010gaa.1	-	3	573	c.354G>A	c.(352-354)CCG>CCA	p.P118P	C20orf46_uc002weq.1_Silent_p.P118P	NM_018354	NP_060824	Q9NUR3	CT046_HUMAN	hypothetical protein LOC55321	118						integral to membrane	protein binding			ovary(1)	1						CATAATCCACCGGGCGGCTCA	0.627													22	94					0	0	0	0	T	1161909	T	T	1161909	2	4	20	1	0	0	0	0	0	0	0	1	2123	639	23	1		1	C20orf46	20	1161909	Silent	SNP	C	TCGA-BA-6873-01A-11D-1870-08		1161909	61863611	70	4461											
SPATA2	9825	broad.mit.edu	37	chr20	48524766	48524766	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtctccagcatgctgaaggCgccgtgcagagcccgcaggc	7	5	14	15	4	1	2	0	1	1	1	2	2	1	2	3	2	4	4	3	2	1	0	rs150565930		TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr20:48524766C>A	uc010gie.2	-	2	612	c.262G>T	c.(262-264)GCC>TCC	p.A88S	SPATA2_uc002xuw.2_Missense_Mutation_p.A88S|SPATA2_uc010zyn.1_Intron	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	88					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			ATGCTGAAGGCGCCGTGCAGA	0.577													46	98					3.21987e-24	3.56241e-24	1	0	A	48524766	A	A	48524766	3	1	20	1	0	0	0	0	1	0	0	0	15071	768	27	3	1308	3	SPATA2	20	48524766	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08	47362857	48524766	14500754	71	4462											
SON	6651	broad.mit.edu	37	chr21	34922496	34922496	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgaggtgtaccctgagcCaagcacatcaacaacaatgg	14	7	9	11	0	1	2	1	2	0	0	1	2	1	2	2	2	6	2	2	2	6	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr21:34922496C>G	uc002yse.1	+	3	1008	c.959C>G	c.(958-960)CCA>CGA	p.P320R	SON_uc002ysb.1_Missense_Mutation_p.P320R|SON_uc002ysc.2_Missense_Mutation_p.P320R|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	320					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TACCCTGAGCCAAGCACATCA	0.468											OREG0003564	type=REGULATORY REGION|Gene=AK074269|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	13	104					0	0	0	0	G	34922496	G	G	34922496	3	3	20	1	0	0	0	0	1	0	0	0	14990	594	21	4	969	4	SON	21	34922496	Missense_Mutation	SNP	C	TCGA-BA-6873-01A-11D-1870-08		34922496	13207399	72	4463											
FAM3B	54097	broad.mit.edu	37	chr21	42710379	42710379	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctatgcctacaggttactcAgcggaggtggcagaagcaag	11	7	13	10	1	1	1	1	0	0	1	1	2	1	2	2	4	5	3	2	4	5	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr21:42710379A>G	uc002yzb.1	+	3	384	c.238A>G	c.(238-240)AGC>GGC	p.S80G	FAM3B_uc002yza.2_RNA|FAM3B_uc002yzc.1_Missense_Mutation_p.S32G|FAM3B_uc002yzd.1_Missense_Mutation_p.S103G|FAM3B_uc011aeq.1_Missense_Mutation_p.S94G	NM_058186	NP_478066	P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	80					apoptosis|insulin secretion	extracellular space	cytokine activity				0		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				CAGGTTACTCAGCGGAGGTGG	0.458													4	123					0	0	0	0	G	42710379	G	G	42710379	3	3	20	1	0	0	0	0	1	0	0	0	5589	188	7	5	248	5	FAM3B	21	42710379	Missense_Mutation	SNP	A	TCGA-BA-6873-01A-11D-1870-08	7787883	42710379	5419516	73	4464											
COL6A1	1291	broad.mit.edu	37	chr21	47409674	47409674	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgggtgtgtagggagaaaaAgggagccgtggggagaaggt	11	6	21	3	1	0	2	0	0	0	2	0	5	0	3	1	6	1	1	1	6	4	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr21:47409674A>G	uc002zhu.1	+	11	1014	c.912A>G	c.(910-912)AAA>AAG	p.K304K		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	304	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	AGGGAGAAAAAGGGAGCCGTG	0.637													3	115					0	0	0	0	G	47409674	G	G	47409674	2	3	20	1	0	0	0	0	0	0	0	1	3714	69	3	5		5	COL6A1	21	47409674	Silent	SNP	A	TCGA-BA-6873-01A-11D-1870-08	4699295	47409674	720221	74	4465											
SFI1	9814	broad.mit.edu	37	chr22	31979944	31979944	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccccttactgcatgctgcCtgggaccactacaggtaggg	7	9	11	14	0	0	0	0	0	0	0	1	1	1	1	4	3	5	3	4	3	3	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr22:31979944C>G	uc003ale.2	+	13	1725	c.1332C>G	c.(1330-1332)GCC>GCG	p.A444A	SFI1_uc003ald.1_Silent_p.A420A|SFI1_uc003alf.2_Silent_p.A413A|SFI1_uc003alg.2_Silent_p.A362A|SFI1_uc011alp.1_Silent_p.A362A|SFI1_uc011alq.1_Silent_p.A389A|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	444					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						TGCATGCTGCCTGGGACCACT	0.517													62	123					0	0	0	0	G	31979944	G	G	31979944	2	3	20	1	0	0	0	0	0	0	0	1	14221	668	24	4		4	SFI1	22	31979944	Silent	SNP	C	TCGA-BA-6873-01A-11D-1870-08		31979944	19324622	75	4466											
TNRC6B	23112	broad.mit.edu	37	chr22	40669448	40669448	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattccaaatctatgcaagaCggctggggggagagtgacgg	11	7	16	7	2	1	3	0	1	1	2	2	5	2	3	1	5	1	2	1	5	3	2			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr22:40669448C>T	uc011aor.1	+	7	3196	c.2985C>T	c.(2983-2985)GAC>GAT	p.D995D	TNRC6B_uc003aym.2_Silent_p.D248D|TNRC6B_uc003ayn.3_Silent_p.D942D|TNRC6B_uc003ayo.2_Silent_p.D799D	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	995					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						CTATGCAAGACGGCTGGGGGG	0.483													5	6					0	0	0	0	T	40669448	T	T	40669448	2	4	20	1	0	0	0	0	0	0	0	1	16407	535	19	1		1	TNRC6B	22	40669448	Silent	SNP	C	TCGA-BA-6873-01A-11D-1870-08	8689504	40669448	10635118	76	4467											
PANX2	56666	broad.mit.edu	37	chr22	50615649	50615649	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actgttaccaccgggcggccGagggccgcgcgcccaagatc	7	4	14	16	6	0	1	0	0	0	1	1	2	0	1	5	3	1	1	5	3	2	1			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chr22:50615649G>A	uc003bjn.3	+	2	508	c.508G>A	c.(508-510)GAG>AAG	p.E170K	PANX2_uc003bjp.3_Missense_Mutation_p.E36K|PANX2_uc003bjo.3_Missense_Mutation_p.E170K	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	170	Cytoplasmic (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		CCGGGCGGCCGAGGGCCGCGC	0.662													4	10					0	0	0	0	A	50615649	A	A	50615649	3	1	20	1	0	0	0	0	1	0	0	0	11475	1059	37	1	514	1	PANX2	22	50615649	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	9946201	50615649	688917	77	4468											
FRMPD4	9758	broad.mit.edu	37	chrX	12736856	12736856	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattaacaccgaacccctgtTtggcacattgagagatggat	12	10	9	10	1	0	2	0	1	0	1	0	5	0	3	3	2	2	2	3	2	2	3			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chrX:12736856T>G	uc004cuz.1	+	16	4417	c.3911T>G	c.(3910-3912)TTT>TGT	p.F1304C	FRMPD4_uc011mij.1_Missense_Mutation_p.F1296C	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1304					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						GAACCCCTGTTTGGCACATTG	0.507													72	67					0	0	0	0	G	12736856	G	G	12736856	3	3	20	1	0	0	0	0	1	0	0	0	6093	1841	64	5	3973	5	FRMPD4	23	12736856	Missense_Mutation	SNP	T	TCGA-BA-6873-01A-11D-1870-08		12736856	142533704	78	4469											
CACNA1F	778	broad.mit.edu	37	chrX	49089767	49089767	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttcccgccttcagattccGacatctttctttcgagattg	6	16	6	13	3	3	2	1	0	2	2	6	4	5	2	3	0	0	0	3	0	0	6			TCGA-BA-6873-01A-11D-1870-08	TCGA-BA-6873-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f65b842c-257e-4ac7-a155-23d3ac12d41c	f976fe92-00c7-45c7-8acd-32cf2ae2e9e4	g.chrX:49089767G>A	uc004dnb.2	-	1	67	c.5C>T	c.(4-6)TCG>TTG	p.S2L	CACNA1F_uc010nip.2_Missense_Mutation_p.S2L|CCDC22_uc011mna.1_5'Flank|CCDC22_uc004dnc.1_5'Flank|CCDC22_uc004dnd.1_5'Flank	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	2	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	TTCAGATTCCGACATCTTTCT	0.577													23	13					0	0	0	0	A	49089767	A	A	49089767	3	1	20	1	0	0	0	0	1	0	0	0	2555	1059	37	1	6120	1	CACNA1F	23	49089767	Missense_Mutation	SNP	G	TCGA-BA-6873-01A-11D-1870-08	36352911	49089767	106180793	79	4470											
ACTRT2	140625	broad.mit.edu	37	chr1	2939160	2939160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggagattgtgctgtcggggGgcactaccctgttccacggg	5	9	17	10	2	0	1	0	0	0	1	2	2	1	1	2	5	2	3	2	5	1	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:2939160G>A	uc001ajz.2	+	1	1115	c.910G>A	c.(910-912)GGC>AGC	p.G304S		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	304						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GCTGTCGGGGGGCACTACCCT	0.612													24	53					0	0	0	0	A	2939160	A	A	2939160	3	1	21	1	0	0	0	0	1	0	0	0	219	1232	43	4	912	4	ACTRT2	1	2939160	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08		2939160	246311461	1	4471											
CAMTA1	23261	broad.mit.edu	37	chr1	7798137	7798138	+	Silent	DNP	GC	AT	AT																															ttccagacaaggcaggagaaGctgcttcccactgcactgag																										TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:7798137_7798138GC>AT	uc001aoi.2	+	16	3984_3985	c.3777_3778GC>AT	c.(3775-3780)AAGCTG>AAATTG	p.1259_1260KL>KL	CAMTA1_uc010nzv.1_Silent_p.346_347KL>KL|CAMTA1_uc001aok.3_Silent_p.302_303KL>KL|CAMTA1_uc001aoj.2_Silent_p.215_216KL>KL	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1259_1260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GGCAGGAGAAGCTGCTTCCCAC	0.495													9	41					0	0	0	0	AT	7798138	AT	AT	7798137	2	1	21	1	0	0	0	0	0	0	0	1	2625	962	34	4		4	CAMTA1	1	7798137	Silent	DNP	GC	TCGA-BA-7269-01A-11D-2012-08	4858977	7798137	241452484	2	4472											
PABPC4	8761	broad.mit.edu	37	chr1	40034520	40034520	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaactgttcaaatttccgtTttaactctgcctgccgttct	7	17	5	12	2	4	0	2	0	2	0	5	0	5	0	3	0	4	3	3	0	3	5			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:40034520T>A	uc010oiv.1	-	6	1728	c.830A>T	c.(829-831)AAA>ATA	p.K277I	PABPC4_uc001cdl.2_Missense_Mutation_p.K277I|PABPC4_uc001cdm.2_Missense_Mutation_p.K277I|SNORA55_uc001cdo.1_5'Flank	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	277					blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AAATTTCCGTTTTAACTCTGC	0.418													28	64					0	0	0	0	A	40034520	A	A	40034520	3	1	21	1	0	0	0	0	1	0	0	0	11420	1841	64	5	1192	5	PABPC4	1	40034520	Missense_Mutation	SNP	T	TCGA-BA-7269-01A-11D-2012-08	32236383	40034520	209216101	3	4473											
CMPK1	51727	broad.mit.edu	37	chr1	47834266	47834266	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagattgtaccagttgagatAaccatcagtttattaaagag	16	12	8	5	0	1	3	1	1	0	3	1	4	1	3	2	0	2	3	2	0	6	7			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:47834266A>G	uc001cri.2	+	2	446	c.297A>G	c.(295-297)ATA>ATG	p.I99M	CMPK1_uc010omp.1_Intron|CMPK1_uc010omq.1_RNA	NM_016308	NP_057392	P30085	KCY_HUMAN	UMP-CMP kinase 1 isoform a	67					nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleus	ATP binding|cytidylate kinase activity|nucleoside phosphate kinase activity|uridine kinase activity			ovary(1)	1					Gemcitabine(DB00441)	CAGTTGAGATAACCATCAGTT	0.353													8	24					0	0	0	0	G	47834266	G	G	47834266	3	3	21	1	0	0	0	0	1	0	0	0	3595	352	13	5	303	5	CMPK1	1	47834266	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	7799746	47834266	201416355	4	4474											
C1orf83	127428	broad.mit.edu	37	chr1	54562121	54562121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggctcgctgccagtcggcaCgtttgtacagacccacaaaa	10	7	10	14	4	0	1	0	0	0	1	2	1	0	1	2	2	2	5	2	2	3	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:54562121C>T	uc001cwt.1	+	5	802	c.602C>T	c.(601-603)ACG>ATG	p.T201M	C1orf83_uc001cwu.1_RNA	NM_153035	NP_694580	Q96MN5	TEAN2_HUMAN	hypothetical protein LOC127428	201	TFIIS central.				transcription, DNA-dependent	nucleus	DNA binding				0						CCAGTCGGCACGTTTGTACAG	0.582													7	53					0	0	0	0	T	54562121	T	T	54562121	3	4	21	1	0	0	0	0	1	0	0	0	2070	536	19	1	616	1	C1orf83	1	54562121	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	6727855	54562121	194688500	5	4475											
FUBP1	8880	broad.mit.edu	37	chr1	78430374	78430374	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttgacccatactcattcCgaacttctctgaaaccgcct	9	13	4	15	2	3	2	1	2	2	0	5	3	4	2	4	0	3	0	4	0	3	5			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:78430374C>T	uc001dii.2	-	10	883	c.794G>A	c.(793-795)CGG>CAG	p.R265Q	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Missense_Mutation_p.R286Q	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	265					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						ATACTCATTCCGAACTTCTCT	0.353													17	57					0	0	0	0	T	78430374	T	T	78430374	3	4	21	1	0	0	0	0	1	0	0	0	6126	652	23	1	1184	1	FUBP1	1	78430374	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	23868253	78430374	170820247	6	4476											
OLFM3	118427	broad.mit.edu	37	chr1	102271700	102271700	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgggttccagatgtcttgaCtgtaactgggcctgtgattt	6	15	12	8	1	1	3	0	2	1	1	3	3	2	3	2	2	1	2	2	2	1	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:102271700C>A	uc001duf.2	-	5	762	c.691G>T	c.(691-693)GTC>TTC	p.V231F	OLFM3_uc001dug.2_Missense_Mutation_p.V211F|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.V136F|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	231	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		GATGTCTTGACTGTAACTGGG	0.428													10	31					2.68362e-12	3.127e-12	1	0	A	102271700	A	A	102271700	3	1	21	1	0	0	0	0	1	0	0	0	10908	565	20	4	753	4	OLFM3	1	102271700	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	23841326	102271700	146978921	7	4477											
RFX5	5993	broad.mit.edu	37	chr1	151316211	151316211	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagatcgggcagagatgaGatgctgctgtagcaggaagc	11	7	16	7	1	0	3	0	1	0	3	1	6	0	4	0	2	5	6	0	2	2	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:151316211G>T	uc001exv.1	-	9	917	c.703C>A	c.(703-705)CTC>ATC	p.L235I	RFX5_uc001exw.1_Missense_Mutation_p.L235I|RFX5_uc009wmr.1_Missense_Mutation_p.L235I|RFX5_uc010pcx.1_Missense_Mutation_p.L195I	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	235						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCAGAGATGAGATGCTGCTGT	0.582													35	110					2.20262e-25	2.78444e-25	1	0	T	151316211	T	T	151316211	3	4	21	1	0	0	0	0	1	0	0	0	13331	942	33	2	1159	2	RFX5	1	151316211	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	49044511	151316211	97934410	8	4478											
SLC27A3	11000	broad.mit.edu	37	chr1	153749041	153749041	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgcccgccctgagagccatgGggctccacctgtgggctgca	5	7	14	15	1	0	1	0	1	0	1	1	2	1	1	5	3	3	3	5	3	0	0			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:153749041G>T	uc001fcz.2	+	2	921	c.856G>T	c.(856-858)GGG>TGG	p.G286W	SLC27A3_uc009won.2_RNA	NM_024330	NP_077306	Q5K4L6	S27A3_HUMAN	solute carrier family 27 member 3	286					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			ovary(1)	1	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GAGAGCCATGGGGCTCCACCT	0.627													4	152					1.23904e-05	1.32825e-05	1	0	T	153749041	T	T	153749041	3	4	21	1	0	0	0	0	1	0	0	0	14591	1232	43	4	862	4	SLC27A3	1	153749041	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	2432830	153749041	95501580	9	4479											
ATP8B2	57198	broad.mit.edu	37	chr1	154303375	154303378	+	Frame_Shift_Del	DEL	ACTT	-	-																															agttccaggaagttgccaacActtacttcctgttcctcctc																										TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:154303375_154303378delACTT	uc001fey.1	+	3	421_424	c.232_235delACTT	c.(232-237)ACTTACfs	p.T78fs	ATP8B2_uc001few.2_Frame_Shift_Del_p.T59fs|ATP8B2_uc001fex.2_Frame_Shift_Del_p.T92fs	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	78_79	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGTTGCCAACACTTACTTCCTGTT	0.461													---	---	---								-	154303378	-	-	154303375	7	5	21	1	0	1	0	1	0	0	0	0	1197	159	6	0	288	0	ATP8B2	1	154303375	Frame_Shift_Del	DEL	ACTT	TCGA-BA-7269-01A-11D-2012-08	554334	154303375	94947246	10	4480											
CD5L	922	broad.mit.edu	37	chr1	157811469	157811469	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagagatactcaccaaggAtcaaggagaatagcagagcc	16	5	11	9	0	2	3	2	0	0	3	2	6	2	4	2	2	4	2	2	2	5	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:157811469A>G	uc001frk.3	-	1	166	c.23T>C	c.(22-24)ATC>ACC	p.I8T		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	8					apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTCACCAAGGATCAAGGAGAA	0.453													5	25					0	0	0	0	G	157811469	G	G	157811469	3	3	21	1	0	0	0	0	1	0	0	0	3042	333	12	5	1044	5	CD5L	1	157811469	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	3508094	157811469	91439152	11	4481											
PAPPA2	60676	broad.mit.edu	37	chr1	176738821	176738821	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtggactgcggtgttcccGacccgtctttggtgaactat	5	12	12	12	4	1	1	0	1	1	0	2	3	2	2	3	3	2	1	3	3	2	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:176738821G>T	uc001gkz.2	+	16	5566	c.4402G>T	c.(4402-4404)GAC>TAC	p.D1468Y	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1468	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CGGTGTTCCCGACCCGTCTTT	0.507													16	102					0.000308642	0.000325654	1	0	T	176738821	T	T	176738821	3	4	21	1	0	0	0	0	1	0	0	0	11487	1058	37	3	4513	3	PAPPA2	1	176738821	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	18927352	176738821	72511800	12	4482											
ASPM	259266	broad.mit.edu	37	chr1	197072273	197072273	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatcctttattctttttctCactttcataccacgataagc	10	17	2	12	1	3	0	2	0	2	0	5	1	4	0	2	0	2	0	2	0	4	8			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:197072273C>A	uc001gtu.2	-	18	6365	c.6108G>T	c.(6106-6108)GTG>GTT	p.V2036V	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2036	IQ 14.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTCTTTTTCTCACTTTCATAC	0.338													54	59					6.14515e-18	7.41847e-18	1	0	A	197072273	A	A	197072273	2	1	21	1	0	0	0	0	0	0	0	1	1058	813	29	2		2	ASPM	1	197072273	Silent	SNP	C	TCGA-BA-7269-01A-11D-2012-08	20333452	197072273	52178348	13	4483											
ATP2B4	493	broad.mit.edu	37	chr1	203682333	203682333	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagatctggcctaagcttcGggtcctggcgcgatcttctc	6	11	11	13	3	3	1	0	0	3	1	6	2	4	1	2	3	1	1	2	3	2	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:203682333G>C	uc001gzw.2	+	14	3136	c.2252G>C	c.(2251-2253)CGG>CCG	p.R751P	ATP2B4_uc001gzv.2_Missense_Mutation_p.R751P|ATP2B4_uc009xaq.2_Missense_Mutation_p.R751P	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	751	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCTAAGCTTCGGGTCCTGGCG	0.537													26	110					0	0	0	0	C	203682333	C	C	203682333	3	2	21	1	0	0	0	0	1	0	0	0	1144	1116	39	3	2302	3	ATP2B4	1	203682333	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	6610060	203682333	45568288	14	4484											
RPS6KC1	26750	broad.mit.edu	37	chr1	213436154	213436154	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaggctcgctcactcattCaacaggtaatttaactgacc	13	10	7	11	1	3	2	3	1	0	1	4	2	3	2	1	2	2	3	1	2	4	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:213436154C>T	uc010ptr.1	+	14	3244	c.3085C>T	c.(3085-3087)CAA>TAA	p.Q1029*	RPS6KC1_uc001hkd.2_Nonsense_Mutation_p.Q1017*|RPS6KC1_uc010pts.1_Nonsense_Mutation_p.Q817*|RPS6KC1_uc010ptt.1_Nonsense_Mutation_p.Q817*|RPS6KC1_uc010ptu.1_Nonsense_Mutation_p.Q848*|RPS6KC1_uc010ptv.1_Nonsense_Mutation_p.Q564*|RPS6KC1_uc001hke.2_Nonsense_Mutation_p.Q848*	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	1029	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		CTCACTCATTCAACAGGTAAT	0.418													9	48					0	0	0	0	T	213436154	T	T	213436154	4	4	21	1	0	0	0	0	0	1	0	0	13723	827	29	2	3139	2	RPS6KC1	1	213436154	Nonsense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	9753821	213436154	35814467	15	4485											
HIST3H2A	92815	broad.mit.edu	37	chr1	228646356	228646357	+	5'Flank	INS	-	GTGT	GTGT																															ggtgcggccgaatctgagccINSgtgtgtgtgtgtgtgtgtgt																								rs144766104	by1000genomes	TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:228646356_228646357insGTGT	uc001hsy.2	-							NM_033445	NP_254280	Q7L7L0	H2A3_HUMAN	histone cluster 3, H2a						nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1		Prostate(94;0.183)				GAATCTGAGCCgtgtgtgtgtg	0.48													---	---	---								GTGT	228646357	GTGT	GTGT	228646356	6	5	21	0	1	1	1	0	0	0	0	0	7221	667	23	0		0	HIST3H2A	1	228646356	5'Flank	INS	-	TCGA-BA-7269-01A-11D-2012-08	15210202	228646356	20604265	16	4486											
LYST	1130	broad.mit.edu	37	chr1	235952058	235952058	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttggatcatcaacgctttgGatcccagtgaaattatatga	12	13	8	8	1	2	2	2	2	0	0	3	4	3	4	1	2	1	1	1	2	4	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:235952058G>T	uc001hxj.2	-	13	4806	c.4631C>A	c.(4630-4632)TCC>TAC	p.S1544Y	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1544					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CAACGCTTTGGATCCCAGTGA	0.403									Chediak-Higashi_syndrome				9	29					1.12685e-05	1.21773e-05	1	0	T	235952058	T	T	235952058	3	4	21	1	0	0	0	0	1	0	0	0	9179	1174	41	2	6938	2	LYST	1	235952058	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	7305702	235952058	13298563	17	4487											
OR2M2	391194	broad.mit.edu	37	chr1	248344299	248344299	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatctttttctatgatgtcAaaatactagcattgattatg	12	17	5	7	0	3	2	1	2	2	0	3	2	3	2	1	0	2	1	1	0	6	7			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr1:248344299A>G	uc010pzf.1	+	1	1012	c.1012A>G	c.(1012-1014)AAA>GAA	p.K338E		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	338	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTATGATGTCAAAATACTAGC	0.289													23	114					0	0	0	0	G	248344299	G	G	248344299	3	3	21	1	0	0	0	0	1	0	0	0	11064	131	5	5	1014	5	OR2M2	1	248344299	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	12392241	248344299	906322	18	4488											
LCLAT1	253558	broad.mit.edu	37	chr2	30863047	30863047	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaacattcctcaatcagaGaagcacctcctccaaggaga	15	6	6	14	0	2	2	2	0	0	2	5	4	5	2	4	1	2	1	4	1	4	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:30863047G>C	uc002rnj.2	+	7	1016	c.807G>C	c.(805-807)GAG>GAC	p.E269D	LCLAT1_uc010ymp.1_Missense_Mutation_p.E107D|LCLAT1_uc002rnl.2_Missense_Mutation_p.E231D|LCLAT1_uc010ymq.1_Missense_Mutation_p.E231D	NM_182551	NP_872357	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1 isoform 1	269					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			ovary(2)	2						CTCAATCAGAGAAGCACCTCC	0.473													51	63					0	0	0	0	C	30863047	C	C	30863047	3	2	21	1	0	0	0	0	1	0	0	0	8717	933	33	2	829	2	LCLAT1	2	30863047	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08		30863047	212336326	19	4489											
CNNM4	26504	broad.mit.edu	37	chr2	97427416	97427416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggcaccgagaaggagaggcGctatgcccgcaagattgagc	11	5	15	10	3	0	4	0	1	0	3	0	6	0	4	2	3	2	3	2	3	3	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:97427416G>A	uc002swx.2	+	1	778	c.680G>A	c.(679-681)CGC>CAC	p.R227H		NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	227	DUF21.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|ovary(1)	3						AAGGAGAGGCGCTATGCCCGC	0.592													4	69					0	0	0	0	A	97427416	A	A	97427416	3	1	21	1	0	0	0	0	1	0	0	0	3630	1087	38	1	682	1	CNNM4	2	97427416	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	66564369	97427416	145771957	20	4490											
VWA3B	200403	broad.mit.edu	37	chr2	98852910	98852910	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaatcgtcagaaaaggtgaCgcgagaaggaagccaggttt	15	6	13	7	3	1	3	1	1	0	2	2	5	1	4	1	3	1	1	1	3	5	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:98852910C>T	uc002syo.2	+	18	2750	c.2486C>T	c.(2485-2487)ACG>ATG	p.T829M	VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Missense_Mutation_p.T348M|VWA3B_uc002sym.2_Missense_Mutation_p.T829M|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.T486M|VWA3B_uc002syp.1_Missense_Mutation_p.T221M|VWA3B_uc002syq.1_Missense_Mutation_p.T105M|VWA3B_uc002syr.1_Missense_Mutation_p.T146M|VWA3B_uc010fih.1_5'Flank	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	829										ovary(3)|large_intestine(2)|skin(1)	6						GAAAAGGTGACGCGAGAAGGA	0.423													22	45					0	0	0	0	T	98852910	T	T	98852910	3	4	21	1	0	0	0	0	1	0	0	0	17309	536	19	1	2552	1	VWA3B	2	98852910	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	1425494	98852910	144346463	21	4491											
INPP4A	3631	broad.mit.edu	37	chr2	99160454	99160454	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taccaggagaacctgaccgaCctccatcagtacagaggtgg	12	6	11	12	1	1	3	1	1	0	2	2	5	2	3	5	3	3	1	5	3	3	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:99160454C>T	uc002syy.2	+	11	1326	c.933C>T	c.(931-933)GAC>GAT	p.D311D	INPP4A_uc010yvj.1_Silent_p.D311D|INPP4A_uc010yvk.1_Silent_p.D311D|INPP4A_uc002syx.2_Silent_p.D311D|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	311					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						ACCTGACCGACCTCCATCAGT	0.488													3	5					0	0	0	0	T	99160454	T	T	99160454	2	4	21	1	0	0	0	0	0	0	0	1	7791	506	18	4		4	INPP4A	2	99160454	Silent	SNP	C	TCGA-BA-7269-01A-11D-2012-08	307544	99160454	144038919	22	4492											
POTEE	445582	broad.mit.edu	37	chr2	131976382	131976382	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcccaggtaccacgtccGtggagaagatctggacaagc	11	5	14	11	2	1	2	0	0	1	2	2	5	2	4	3	4	3	1	3	4	3	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:131976382G>A	uc002tsn.2	+	1	459	c.407G>A	c.(406-408)CGT>CAT	p.R136H	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Translation_Start_Site|POTEE_uc002tsl.2_Translation_Start_Site	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	136							ATP binding				0						TACCACGTCCGTGGAGAAGAT	0.592													29	78					0	0	0	0	A	131976382	A	A	131976382	3	1	21	1	0	0	0	0	1	0	0	0	12319	1145	40	1	409	1	POTEE	2	131976382	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	32815928	131976382	111222991	23	4493											
KYNU	8942	broad.mit.edu	37	chr2	143712382	143712382	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atatgtttattttacaggagCcaatgagaaagaaatagccc	16	11	8	6	0	0	2	0	1	0	2	0	4	0	3	2	1	3	1	2	1	7	6			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:143712382C>G	uc002tvl.2	+	5	507	c.377C>G	c.(376-378)GCC>GGC	p.A126G	KYNU_uc002tvk.2_Missense_Mutation_p.A126G|KYNU_uc010fnm.2_Missense_Mutation_p.A126G	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	126					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTTACAGGAGCCAATGAGAAA	0.299													3	28					0	0	0	0	G	143712382	G	G	143712382	3	3	21	1	0	0	0	0	1	0	0	0	8627	739	26	4	391	4	KYNU	2	143712382	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	11736000	143712382	99486991	24	4494											
NFE2L2	4780	broad.mit.edu	37	chr2	178096545	178096545	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcactgtcaactggttgggGtcttctgtggagaggatgct	6	14	14	7	0	4	1	2	0	2	1	4	3	4	2	0	5	2	2	0	5	1	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:178096545G>C	uc002ulh.3	-	5	1341	c.786C>G	c.(784-786)GAC>GAG	p.D262E	NFE2L2_uc002ulg.3_Missense_Mutation_p.D246E|NFE2L2_uc010zfa.1_Missense_Mutation_p.D239E|NFE2L2_uc002uli.3_Missense_Mutation_p.D246E	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	262					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ACTGGTTGGGGTCTTCTGTGG	0.403			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			10	41					0	0	0	0	C	178096545	C	C	178096545	3	2	21	1	0	0	0	0	1	0	0	0	10422	1252	44	4	1035	4	NFE2L2	2	178096545	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	34384163	178096545	65102828	25	4495											
TTN	7273	broad.mit.edu	37	chr2	179471858	179471858	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccctcaagcagacctgtgAtgtcacatttagatctctca	10	12	7	12	0	4	3	3	1	1	2	6	3	5	3	2	0	1	1	2	0	2	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:179471858A>G	uc010zfg.1	-	227	45991	c.45767T>C	c.(45766-45768)ATC>ACC	p.I15256T	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I8951T|TTN_uc010zfi.1_Missense_Mutation_p.I8884T|TTN_uc010zfj.1_Missense_Mutation_p.I8759T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16183							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGACCTGTGATGTCACATTT	0.413													24	130					0	0	0	0	G	179471858	G	G	179471858	3	3	21	1	0	0	0	0	1	0	0	0	16803	333	12	5	54562	5	TTN	2	179471858	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	1375313	179471858	63727515	26	4496											
ZNF142	7701	broad.mit.edu	37	chr2	219510940	219510940	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcacacggaggtagtgctTccacttggtgacatagccac	9	9	12	11	1	0	1	0	1	0	0	1	2	1	2	2	3	3	3	2	3	2	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:219510940T>A	uc002vin.2	-	7	1841	c.1405A>T	c.(1405-1407)AAG>TAG	p.K469*	ZNF142_uc002vil.2_Nonsense_Mutation_p.K430*|ZNF142_uc010fvt.2_Nonsense_Mutation_p.K306*|ZNF142_uc002vim.2_Nonsense_Mutation_p.K306*	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	469	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGGTAGTGCTTCCACTTGGTG	0.517													43	56					0	0	0	0	A	219510940	A	A	219510940	4	1	21	1	0	0	0	0	0	1	0	0	17798	1792	62	5	3674	5	ZNF142	2	219510940	Nonsense_Mutation	SNP	T	TCGA-BA-7269-01A-11D-2012-08	40039082	219510940	23688433	27	4497											
COPS7B	64708	broad.mit.edu	37	chr2	232653363	232653363	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccagtggctcagccctcaCtgctctcataagccaggtct	8	10	8	15	0	4	0	3	0	2	0	5	0	4	0	3	2	4	2	3	2	2	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr2:232653363C>A	uc002vsg.1	+	2	186	c.83C>A	c.(82-84)ACT>AAT	p.T28N	COPS7B_uc010fxy.1_Intron|COPS7B_uc002vsh.1_Missense_Mutation_p.T28N|COPS7B_uc002vsi.1_Translation_Start_Site|COPS7B_uc002vsj.1_5'Flank	NM_022730	NP_073567	Q9H9Q2	CSN7B_HUMAN	COP9 constitutive photomorphogenic homolog	28					cullin deneddylation	cytoplasm|signalosome				ovary(1)|liver(1)|skin(1)	3		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;1.36e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00136)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		TCAGCCCTCACTGCTCTCATA	0.498													29	41					8.58068e-18	1.02662e-17	1	0	A	232653363	A	A	232653363	3	1	21	1	0	0	0	0	1	0	0	0	3754	565	20	4	85	4	COPS7B	2	232653363	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	13142423	232653363	10546010	28	4498											
FANCD2	2177	broad.mit.edu	37	chr3	10122836	10122836	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccaacagagatctgcccAagaaattgttcattgtgttt	11	14	7	9	0	3	2	1	0	2	2	4	3	3	2	2	0	2	2	2	0	3	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:10122836A>G	uc003buw.2	+	31	3107	c.3029A>G	c.(3028-3030)CAA>CGA	p.Q1010R	FANCD2_uc003bux.1_Missense_Mutation_p.Q1010R|FANCD2_uc003buy.1_Missense_Mutation_p.Q1010R|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1010					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AGATCTGCCCAAGAAATTGTT	0.408			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				18	46					0	0	0	0	G	10122836	G	G	10122836	3	3	21	1	0	0	0	0	1	0	0	0	5697	130	5	5	3147	5	FANCD2	3	10122836	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08		10122836	187899594	29	4499											
CAND2	23066	broad.mit.edu	37	chr3	12858258	12858258	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgaccggcttggggatgaCctggagcccacgttactgct	6	9	15	11	2	0	2	0	2	0	0	0	4	0	4	3	5	3	3	3	5	1	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:12858258C>G	uc003bxk.2	+	10	1876	c.1827C>G	c.(1825-1827)GAC>GAG	p.D609E	CAND2_uc003bxj.2_Missense_Mutation_p.D516E	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	609	HEAT 13.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						TTGGGGATGACCTGGAGCCCA	0.647													23	149					0	0	0	0	G	12858258	G	G	12858258	3	3	21	1	0	0	0	0	1	0	0	0	2628	506	18	4	1865	4	CAND2	3	12858258	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	2735422	12858258	185164172	30	4500											
SLC4A7	9497	broad.mit.edu	37	chr3	27477926	27477926	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcatatccagcatgactgttCcattgaggatgcaactcctt	10	13	7	11	0	1	2	1	2	0	0	4	3	4	3	3	1	3	3	3	1	2	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:27477926C>A	uc003cdv.2	-	5	586	c.515G>T	c.(514-516)GGA>GTA	p.G172V	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.G177V|SLC4A7_uc011aww.1_Missense_Mutation_p.G181V|SLC4A7_uc011awx.1_Missense_Mutation_p.G181V|SLC4A7_uc011awy.1_Missense_Mutation_p.G177V|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.G177V|SLC4A7_uc011axb.1_Missense_Mutation_p.G181V|SLC4A7_uc010hfm.2_Missense_Mutation_p.G177V|SLC4A7_uc003cdw.2_Missense_Mutation_p.G172V	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	172	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						CATGACTGTTCCATTGAGGAT	0.393													11	30					4.68919e-08	5.28026e-08	1	0	A	27477926	A	A	27477926	3	1	21	1	0	0	0	0	1	0	0	0	14722	855	30	2	3213	2	SLC4A7	3	27477926	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	14619668	27477926	170544504	31	4501											
SETD2	29072	broad.mit.edu	37	chr3	47162207	47162207	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aggtctacctgatcttggatCccagtaaccattgccttgcc	8	12	8	13	0	2	1	0	1	2	0	3	2	3	2	5	2	4	1	5	2	2	5			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:47162207C>G	uc003cqs.2	-	3	3972	c.3919G>C	c.(3919-3921)GAT>CAT	p.D1307H	SETD2_uc003cqv.2_Missense_Mutation_p.D1296H	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GATCTTGGATCCCAGTAACCA	0.473			N|F|S|Mis		clear cell renal carcinoma								10	31					0	0	0	0	G	47162207	G	G	47162207	3	3	21	1	0	0	0	0	1	0	0	0	14196	855	30	2	3851	2	SETD2	3	47162207	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	19684281	47162207	150860223	32	4502											
SLC12A8	84561	broad.mit.edu	37	chr3	124906105	124906105	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaaacacatagagcagcccGatggtgcctcccgtctgccc	9	6	9	17	2	1	1	0	0	1	1	2	2	2	1	5	1	5	1	5	1	2	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:124906105G>A	uc003ehv.3	-	4	477	c.366C>T	c.(364-366)ATC>ATT	p.I122I	SLC12A8_uc003ehw.3_Silent_p.I151I|SLC12A8_uc010hrz.1_5'UTR	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	122					potassium ion transport	integral to membrane	symporter activity				0						AGAGCAGCCCGATGGTGCCTC	0.627													14	72					0	0	0	0	A	124906105	A	A	124906105	2	1	21	1	0	0	0	0	0	0	0	1	14454	1048	37	1		1	SLC12A8	3	124906105	Silent	SNP	G	TCGA-BA-7269-01A-11D-2012-08	77743898	124906105	73116325	33	4503											
PLD1	5337	broad.mit.edu	37	chr3	171394572	171394572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgccttcccgtggactgcaGaggcaatgtcatgccagggc	7	7	13	14	2	1	1	1	0	0	1	2	2	2	2	4	3	2	2	4	3	1	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr3:171394572G>A	uc003fhs.2	-	18	2164	c.2048C>T	c.(2047-2049)TCT>TTT	p.S683F	PLD1_uc003fht.2_Missense_Mutation_p.S645F|PLD1_uc003fhu.3_5'Flank|PLD1_uc003fhv.1_Missense_Mutation_p.S8F	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	683	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GTGGACTGCAGAGGCAATGTC	0.532													8	81					0	0	0	0	A	171394572	A	A	171394572	3	1	21	1	0	0	0	0	1	0	0	0	12100	942	33	2	1216	2	PLD1	3	171394572	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	46488467	171394572	26627858	34	4504											
TBCK	93627	broad.mit.edu	37	chr4	107016738	107016738	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgggtaagctccccttcTgcagtgaaggcagcactgaa	9	8	11	13	0	1	2	0	2	1	0	2	2	2	2	3	2	3	5	3	2	3	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr4:107016738T>G	uc010ilv.2	-	25	2837	c.2472A>C	c.(2470-2472)GCA>GCC	p.A824A	TBCK_uc003hyb.2_Silent_p.A567A|TBCK_uc003hye.2_Silent_p.A785A|TBCK_uc003hyc.2_Silent_p.A761A|TBCK_uc003hyd.2_Silent_p.A652A|TBCK_uc003hyf.2_Silent_p.A824A	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	824	Rhodanese.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						GCTCCCCTTCTGCAGTGAAGG	0.468													11	45					0	0	0	0	G	107016738	G	G	107016738	2	3	21	1	0	0	0	0	0	0	0	1	15702	1567	55	5		5	TBCK	4	107016738	Silent	SNP	T	TCGA-BA-7269-01A-11D-2012-08		107016738	84137538	35	4505											
KIAA0922	23240	broad.mit.edu	37	chr4	154525199	154525199	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acagacttcacccctgggcaGctcactgcctgctgctaaag	9	8	9	15	0	2	1	2	0	0	1	2	1	2	1	3	1	4	4	3	1	2	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr4:154525199G>A	uc003inm.3	+	25	3084	c.3032G>A	c.(3031-3033)AGC>AAC	p.S1011N	KIAA0922_uc010ipp.2_Missense_Mutation_p.S1012N|KIAA0922_uc010ipq.2_Missense_Mutation_p.S780N	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1011	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CCCCTGGGCAGCTCACTGCCT	0.502													13	67					0	0	0	0	A	154525199	A	A	154525199	3	1	21	1	0	0	0	0	1	0	0	0	8240	971	34	4	3133	4	KIAA0922	4	154525199	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	47508461	154525199	36629077	36	4506											
ADAM29	11086	broad.mit.edu	37	chr4	175898746	175898746	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttattgttttgtttattttAttatgttgtctttatcgact	6	26	5	4	1	1	0	0	0	1	0	2	1	1	0	0	0	0	3	0	0	5	12			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr4:175898746A>T	uc003iuc.2	+	5	2740	c.2070A>T	c.(2068-2070)TTA>TTT	p.L690F	ADAM29_uc003iud.2_Missense_Mutation_p.L690F|ADAM29_uc010irr.2_Missense_Mutation_p.L690F|ADAM29_uc011cki.1_Missense_Mutation_p.L690F	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	690	Helical; (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGTTTATTTTATTATGTTGTC	0.343													9	19					0	0	0	0	T	175898746	T	T	175898746	3	4	21	1	0	0	0	0	1	0	0	0	247	446	16	5	2072	5	ADAM29	4	175898746	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	21373547	175898746	15255530	37	4507											
FAT1	2195	broad.mit.edu	37	chr4	187628726	187628732	+	Frame_Shift_Del	DEL	CAGTTTT	-	-																															cctccagaaacagcatagacCagttttccattgaagccagt																										TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr4:187628726_187628732delCAGTTTT	uc003izf.2	-	2	2438_2444	c.2250_2256delAAAACTG	c.(2248-2256)GGAAAACTGfs	p.G750fs	FAT1_uc010iso.1_Frame_Shift_Del_p.G750fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	750_752	Extracellular (Potential).|Cadherin 6.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CAGCATAGACCAGTTTTCCATTGAAGC	0.425										HNSCC(5;0.00058)			---	---	---								-	187628732	-	-	187628726	7	5	21	1	0	1	0	1	0	0	0	0	5721	581	21	0	11614	0	FAT1	4	187628726	Frame_Shift_Del	DEL	CAGTTTT	TCGA-BA-7269-01A-11D-2012-08	11729980	187628726	3525550	38	4508											
TTC37	9652	broad.mit.edu	37	chr5	94820469	94820469	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcagatattcttcctgtgtCtattagaccagtgacagctt	9	16	7	9	0	3	3	1	1	2	2	4	3	4	3	2	0	1	1	2	0	3	7			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr5:94820469C>G	uc003klb.2	-	38	4282	c.4012G>C	c.(4012-4014)GAC>CAC	p.D1338H		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1338	TPR 19.						binding			ovary(3)|pancreas(1)	4						CTTCCTGTGTCTATTAGACCA	0.348													18	25					0	0	0	0	G	94820469	G	G	94820469	3	3	21	1	0	0	0	0	1	0	0	0	16773	913	32	2	706	2	TTC37	5	94820469	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08		94820469	86094791	39	4509											
PCDHA12	56137	broad.mit.edu	37	chr5	140256690	140256690	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgacgccggcgtgccgcctCtgggcagcaacgtgacgctg	5	5	16	15	7	1	1	0	1	1	0	1	2	1	1	3	2	3	3	3	2	1	0			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr5:140256690C>G	uc003lic.2	+	1	1760	c.1633C>G	c.(1633-1635)CTG>GTG	p.L545V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.L545V	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	545	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCCGCCTCTGGGCAGCAA	0.697													36	79					0	0	0	0	G	140256690	G	G	140256690	3	3	21	1	0	0	0	0	1	0	0	0	11576	912	32	2	1635	2	PCDHA12	5	140256690	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	45436221	140256690	40658570	40	4510											
PCDHGB6	56100	broad.mit.edu	37	chr5	140788292	140788292	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagattataagataaactctAatccttatttttcattaatg	16	17	3	5	0	2	2	1	0	1	2	3	2	3	2	1	0	1	0	1	0	8	8			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr5:140788292A>C	uc003lkj.1	+	1	523	c.523A>C	c.(523-525)AAT>CAT	p.N175H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.N175H	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	175	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATAAACTCTAATCCTTATTT	0.388													10	7					0	0	0	0	C	140788292	C	C	140788292	3	2	21	1	0	0	0	0	1	0	0	0	11621	362	13	5	525	5	PCDHGB6	5	140788292	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	531602	140788292	40126968	41	4511											
FAM71B	153745	broad.mit.edu	37	chr5	156590665	156590666	+	Missense_Mutation	DNP	GC	AA	AA																															ccccttctctgtggagctctGcagcctataccaaggggaag																										TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr5:156590665_156590666GC>AA	uc003lwn.2	-	2	710_711	c.610_611GC>TT	c.(610-612)GCA>TTA	p.A204L		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	204						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGAGCTCTGCAGCCTATACC	0.49													18	53					0	0	0	0	AA	156590666	AA	AA	156590665	3	1	21	1	0	0	0	0	1	0	0	0	5640	1319	46	4	1210	4	FAM71B	5	156590665	Missense_Mutation	DNP	GC	TCGA-BA-7269-01A-11D-2012-08	15802373	156590665	24324595	42	4512											
PECI	10455	broad.mit.edu	37	chr6	4135788	4135788	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccaagccaagtacgccaTcgccatcccttgggcggctc	7	8	9	17	3	1	0	0	0	1	0	5	0	2	0	5	2	2	2	5	2	3	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:4135788T>C	uc003mwf.2	-	1	44	c.7A>G	c.(7-9)ATG>GTG	p.M3V	PECI_uc003mwc.2_5'UTR|PECI_uc003mwd.2_5'UTR|PECI_uc003mwe.2_5'UTR|PECI_uc010jnr.1_5'Flank|uc003mwg.1_5'Flank	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	3					fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				AAGTACGCCATCGCCATCCCT	0.652													19	59					0	0	0	0	C	4135788	C	C	4135788	3	2	21	1	0	0	0	0	1	0	0	0	11770	1435	50	5	1217	5	PECI	6	4135788	Missense_Mutation	SNP	T	TCGA-BA-7269-01A-11D-2012-08		4135788	166979279	43	4513											
SCAND3	114821	broad.mit.edu	37	chr6	28540656	28540656	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttcatggcaagactttCtcgatgaatgaagcaatgtg	11	15	9	6	1	2	3	1	2	1	1	3	4	2	3	0	1	1	2	0	1	4	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:28540656C>A	uc003nlo.2	-	4	3628	c.3010G>T	c.(3010-3012)GAA>TAA	p.E1004*		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1004					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						gcaagactttctcgatgaatg	0													16	34					3.51602e-12	4.06161e-12	1	0	A	28540656	A	A	28540656	4	1	21	1	0	0	0	0	0	1	0	0	13941	922	32	2	971	2	SCAND3	6	28540656	Nonsense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	24404868	28540656	142574411	44	4514											
OR2H1	26716	broad.mit.edu	37	chr6	29429639	29429639	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctttgtggttgtcttcacTtcctacctcttgaccctggt	3	18	7	13	0	4	1	1	1	3	0	5	1	5	1	3	2	1	1	3	2	1	6			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:29429639T>A	uc003nmi.2	+	3	536	c.93T>A	c.(91-93)ACT>ACA	p.T31T	OR2H1_uc003nmj.1_Silent_p.T31T|OR2H1_uc010jri.1_Intron	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTGTCTTCACTTCCTACCTCT	0.522													4	166					0	0	0	0	A	29429639	A	A	29429639	2	1	21	1	0	0	0	0	0	0	0	1	11055	1596	56	5		5	OR2H1	6	29429639	Silent	SNP	T	TCGA-BA-7269-01A-11D-2012-08	888983	29429639	141685428	45	4515											
ZFP57	346171	broad.mit.edu	37	chr6	29641487	29641487	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtcatcactagtccccTcatctctcagactgggatgt	7	13	7	14	0	5	1	4	0	1	1	7	2	6	2	3	1	0	0	3	1	1	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:29641487T>C	uc011dlw.1	-	4	552	c.401A>G	c.(400-402)GAG>GGG	p.E134G	ZFP57_uc003nnl.3_Missense_Mutation_p.E114G	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						ACTAGTCCCCTCATCTCTCAG	0.512													3	142					0	0	0	0	C	29641487	C	C	29641487	3	2	21	1	0	0	0	0	1	0	0	0	17718	1551	54	5	1213	5	ZFP57	6	29641487	Missense_Mutation	SNP	T	TCGA-BA-7269-01A-11D-2012-08	211848	29641487	141473580	46	4516											
HLA-F	3134	broad.mit.edu	37	chr6	29692932	29692932	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcgggatggggaggaacaGacccaggacacagagcttgt	12	4	16	9	1	0	2	0	0	0	2	0	6	0	6	1	5	3	1	1	5	1	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:29692932G>C	uc010jrl.2	+	4	859	c.735G>C	c.(733-735)CAG>CAC	p.Q245H	HLA-F_uc003nnm.3_Intron|HLA-F_uc003nno.3_Missense_Mutation_p.Q245H|HLA-F_uc011dlx.1_Missense_Mutation_p.Q245H|HLA-F_uc011dly.1_RNA	NM_018950	NP_061823	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	245	Alpha-3.|Extracellular (Potential).|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						GGGAGGAACAGACCCAGGACA	0.627													14	44					0	0	0	0	C	29692932	C	C	29692932	3	2	21	1	0	0	0	0	1	0	0	0	7250	933	33	2	749	2	HLA-F	6	29692932	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	51445	29692932	141422135	47	4517											
HLA-DMB	3109	broad.mit.edu	37	chr6	32906490	32906490	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggtcagtgatccccagaagGgctgggtgtgtgtggcacaa	8	9	16	8	0	1	2	1	1	0	1	2	2	2	2	2	4	0	2	2	4	2	0			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:32906490G>A	uc003ocl.1	-	2	541	c.308C>T	c.(307-309)CCC>CTC	p.P103L	HLA-DMB_uc003ocj.1_Missense_Mutation_p.P103L|HLA-DMB_uc003ock.1_5'Flank|HLA-DMB_uc010jud.1_5'Flank|HLA-DMB_uc010jue.1_5'Flank|HLA-DMB_uc010juf.1_5'Flank|HLA-DMB_uc011dql.1_Missense_Mutation_p.P103L	NM_002118	NP_002109	P28068	DMB_HUMAN	major histocompatibility complex, class II, DM	103	Beta-1.|Lumenal (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						TCCCCAGAAGGGCTGGGTGTG	0.572													25	77					0	0	0	0	A	32906490	A	A	32906490	3	1	21	1	0	0	0	0	1	0	0	0	7238	1232	43	4	503	4	HLA-DMB	6	32906490	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	3213558	32906490	138208577	48	4518											
DNAH8	1769	broad.mit.edu	37	chr6	38690577	38690577	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtataaagcattccgcaCgacgggggatggagaaggat	14	6	15	6	3	0	1	0	0	0	1	1	6	1	3	1	4	1	3	1	4	5	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:38690577C>T	uc003ooe.1	+	1	26	c.-574C>T	c.(-576--572)CACGA>CATGA		DNAH8_uc003ood.1_Translation_Start_Site	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GCATTCCGCACGACGGGGGAT	0.483													4	14					0	0	0	0	T	38690577	T	T	38690577	1	4	21	1	0	0	0	0	0	0	0	0	4629	551	19	1		1	DNAH8	6	38690577	Translation_Start_Site	SNP	C	TCGA-BA-7269-01A-11D-2012-08	5784087	38690577	132424490	49	4519											
PEX6	5190	broad.mit.edu	37	chr6	42934376	42934376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctccccctcatcctcctCagtcaagccacctgccaaac	9	7	4	21	0	3	0	3	0	0	0	6	0	6	0	7	0	4	1	7	0	2	0			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:42934376C>T	uc003otf.2	-	10	2074	c.1981G>A	c.(1981-1983)GAG>AAG	p.E661K	PEX6_uc010jya.2_RNA	NM_000287	NP_000278	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	661					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)	1			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			TCATCCTCCTCAGTCAAGCCA	0.597													32	128					0	0	0	0	T	42934376	T	T	42934376	3	4	21	1	0	0	0	0	1	0	0	0	11805	835	29	2	993	2	PEX6	6	42934376	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	4243799	42934376	128180691	50	4520											
PAQR8	85315	broad.mit.edu	37	chr6	52268767	52268767	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtaccacaccctccagatCctcttcttcctggttagcgc	6	12	7	16	1	2	1	0	0	2	1	5	1	5	1	5	2	2	2	5	2	2	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:52268767C>A	uc003pao.3	+	2	930	c.756C>A	c.(754-756)ATC>ATA	p.I252I		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	252	Helical; Name=5; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					CCCTCCAGATCCTCTTCTTCC	0.577													17	50					2.23348e-06	2.45317e-06	1	0	A	52268767	A	A	52268767	2	1	21	1	0	0	0	0	0	0	0	1	11495	845	30	2		2	PAQR8	6	52268767	Silent	SNP	C	TCGA-BA-7269-01A-11D-2012-08	9334391	52268767	118846300	51	4521											
GCM1	8521	broad.mit.edu	37	chr6	52993147	52993147	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagaggcgtaggtgaagaGaaaggggtcttcttgaggtg	11	9	18	3	1	2	4	0	3	2	2	2	6	2	4	0	5	0	1	0	5	3	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:52993147G>A	uc003pbp.2	-	6	1377	c.1168C>T	c.(1168-1170)CTC>TTC	p.L390F		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	390						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					TAGGTGAAGAGAAAGGGGTCT	0.443													13	269					0	0	0	0	A	52993147	A	A	52993147	3	1	21	1	0	0	0	0	1	0	0	0	6332	942	33	2	146	2	GCM1	6	52993147	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	724380	52993147	118121920	52	4522											
FBXL4	26235	broad.mit.edu	37	chr6	99374830	99374830	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcatatataataaaacatgGtcagaactgttaacatggga	17	10	9	5	0	1	1	1	0	0	1	1	2	1	2	0	3	3	2	0	3	7	5			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:99374830G>C	uc003ppf.1	-	3	393	c.35C>G	c.(34-36)ACC>AGC	p.T12S	FBXL4_uc003ppg.1_Missense_Mutation_p.T12S|FBXL4_uc003pph.1_5'UTR	NM_012160	NP_036292	Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	12					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				skin(2)	2		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		ATAAAACATGGTCAGAACTGT	0.433													15	75					0	0	0	0	C	99374830	C	C	99374830	3	2	21	1	0	0	0	0	1	0	0	0	5753	1261	44	4	1858	4	FBXL4	6	99374830	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	46381683	99374830	71740237	53	4523											
SIM1	6492	broad.mit.edu	37	chr6	100898154	100898154	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcacctacctgagaaagacCcaagtggactgaggctgtct	11	8	10	12	0	2	3	1	2	1	2	2	5	2	4	3	2	1	1	3	2	3	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:100898154C>T	uc003pqj.3	-	3	544	c.337G>A	c.(337-339)GGT>AGT	p.G113S	SIM1_uc010kcu.2_Missense_Mutation_p.G113S	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	113	PAS 1.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TGAGAAAGACCCAAGTGGACT	0.562													32	107					0	0	0	0	T	100898154	T	T	100898154	3	4	21	1	0	0	0	0	1	0	0	0	14388	623	22	4	1999	4	SIM1	6	100898154	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	1523324	100898154	70216913	54	4524											
LRP11	84918	broad.mit.edu	37	chr6	150174158	150174158	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcatgtccactgacgggTccccctgcagcagtgcccac	6	8	9	18	1	1	1	1	1	0	0	3	1	3	1	5	1	3	2	5	1	0	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr6:150174158T>C	uc003qng.2	-	2	1076	c.752A>G	c.(751-753)GAC>GGC	p.D251G	LRP11_uc003qnh.1_Missense_Mutation_p.D251G	NM_032832	NP_116221	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein	251	PKD.|Extracellular (Potential).					integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		CACTGACGGGTCCCCCTGCAG	0.542													4	54					0	0	0	0	C	150174158	C	C	150174158	3	2	21	1	0	0	0	0	1	0	0	0	9003	1667	58	5	774	5	LRP11	6	150174158	Missense_Mutation	SNP	T	TCGA-BA-7269-01A-11D-2012-08	49276004	150174158	20940909	55	4525											
SDK1	221935	broad.mit.edu	37	chr7	4249658	4249658	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgtgttctattctcccagcCcctggggcccccagctttct	3	14	8	16	0	3	0	0	0	3	0	4	0	3	0	5	2	2	2	5	2	1	5			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:4249658C>T	uc003smx.2	+	38	5542	c.5403C>T	c.(5401-5403)GCC>GCT	p.A1801A	SDK1_uc010kso.2_Silent_p.A1057A|SDK1_uc003smy.2_Silent_p.A288A	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1801					cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TTCTCCCAGCCCCTGGGGCCC	0.522													4	118					0	0	0	0	T	4249658	T	T	4249658	2	4	21	1	0	0	0	0	0	0	0	1	14033	637	22	4		4	SDK1	7	4249658	Silent	SNP	C	TCGA-BA-7269-01A-11D-2012-08		4249658	154889005	56	4526											
EGFR	1956	broad.mit.edu	37	chr7	55210023	55210023	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacgcagttgggcacttttGaagatcattttctcagcctc	8	14	8	11	1	3	2	3	1	1	1	5	2	3	2	1	1	1	3	1	1	1	5			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:55210023G>C	uc003tqk.2	+	2	379	c.133G>C	c.(133-135)GAA>CAA	p.E45Q	EGFR_uc003tqh.2_Missense_Mutation_p.E45Q|EGFR_uc003tqi.2_Missense_Mutation_p.E45Q|EGFR_uc003tqj.2_Missense_Mutation_p.E45Q|EGFR_uc010kzg.1_Missense_Mutation_p.E45Q|EGFR_uc011kco.1_5'UTR	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	45	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGGCACTTTTGAAGATCATTT	0.398		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			5	350					0	0	0	0	C	55210023	C	C	55210023	3	2	21	1	0	0	0	0	1	0	0	0	4989	1291	45	2	139	2	EGFR	7	55210023	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	50960365	55210023	103928640	57	4527											
STEAP4	79689	broad.mit.edu	37	chr7	87910314	87910314	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagagtacaaacagaaaaaaCccaagtattcccaaagccac	21	4	5	11	0	0	2	0	0	0	2	1	2	1	2	3	0	4	2	3	0	9	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:87910314C>T	uc003ujs.2	-	4	1170	c.1065G>A	c.(1063-1065)GGG>GGA	p.G355G	STEAP4_uc010lek.2_Silent_p.G179G	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	355	Ferric oxidoreductase.|Helical; (Potential).				fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					ACAGAAAAAACCCAAGTATTC	0.408													19	34					0	0	0	0	T	87910314	T	T	87910314	2	4	21	1	0	0	0	0	0	0	0	1	15346	494	18	4		4	STEAP4	7	87910314	Silent	SNP	C	TCGA-BA-7269-01A-11D-2012-08	32700291	87910314	71228349	58	4528											
TRRAP	8295	broad.mit.edu	37	chr7	98608797	98608797	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgttccggaagatgttcacCatccagctggctctgatagg	9	10	11	11	2	2	2	1	1	1	1	4	3	4	3	3	3	1	4	3	3	2	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:98608797C>A	uc003upp.2	+	70	11228	c.11019C>A	c.(11017-11019)ACC>ACA	p.T3673T	TRRAP_uc011kis.1_Silent_p.T3644T|TRRAP_uc003upr.2_Silent_p.T3379T|TRRAP_uc003ups.2_5'Flank	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3673	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGATGTTCACCATCCAGCTGG	0.537													20	73					1.96895e-08	2.23592e-08	1	0	A	98608797	A	A	98608797	2	1	21	1	0	0	0	0	0	0	0	1	16668	581	21	4		4	TRRAP	7	98608797	Silent	SNP	C	TCGA-BA-7269-01A-11D-2012-08	10698483	98608797	60529866	59	4529											
FBXO24	26261	broad.mit.edu	37	chr7	100198322	100198322	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccccaggaccccggggggAtggcccaggcctgcgaggag	7	2	17	15	2	0	0	0	0	0	0	0	4	0	3	6	7	1	0	6	7	0	0			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:100198322A>G	uc003uvm.1	+	10	1836	c.1543A>G	c.(1543-1545)ATG>GTG	p.M515V	FBXO24_uc003uvn.1_Missense_Mutation_p.M153V|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Missense_Mutation_p.M553V|FBXO24_uc011kka.1_Missense_Mutation_p.M503V|PCOLCE_uc011kkb.1_5'Flank|PCOLCE_uc003uvo.2_5'Flank|PCOLCE_uc010lhb.1_5'Flank	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	515						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCCCGGGGGGATGGCCCAGGC	0.662													3	50					0	0	0	0	G	100198322	G	G	100198322	3	3	21	1	0	0	0	0	1	0	0	0	5767	333	12	5	1738	5	FBXO24	7	100198322	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	1589525	100198322	58940341	60	4530											
SLC35B4	84912	broad.mit.edu	37	chr7	133979789	133979789	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcgtgacggtgagggaggcGcattctgtggtgaggataaa	10	8	18	5	3	1	3	0	3	1	0	1	5	1	5	0	5	1	1	0	5	2	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr7:133979789G>A	uc003vrn.2	-	10	1116	c.792C>T	c.(790-792)TGC>TGT	p.C264C	SLC35B4_uc010lmk.2_Silent_p.C128C|SLC35B4_uc010lml.1_Intron	NM_032826	NP_116215	Q969S0	S35B4_HUMAN	solute carrier family 35, member B4	264	Helical; (Potential).					Golgi membrane|integral to membrane	UDP-N-acetylglucosamine transmembrane transporter activity|UDP-xylose transmembrane transporter activity			skin(1)	1						TGAGGGAGGCGCATTCTGTGG	0.537													7	377					0	0	0	0	A	133979789	A	A	133979789	2	1	21	1	0	0	0	0	0	0	0	1	14642	1079	38	1		1	SLC35B4	7	133979789	Silent	SNP	G	TCGA-BA-7269-01A-11D-2012-08	33781467	133979789	25158874	61	4531											
CSMD1	64478	broad.mit.edu	37	chr8	3432474	3432474	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcggagccttaccttgtccGggtcggtggtggtgatgacc	4	10	17	10	3	0	2	0	2	0	0	2	3	1	3	4	6	2	0	4	6	1	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr8:3432474G>A	uc011kwk.1	-	10	1730	c.1340C>T	c.(1339-1341)CCG>CTG	p.P447L		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	447	CUB 3.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TACCTTGTCCGGGTCGGTGGT	0.522													16	31					0	0	0	0	A	3432474	A	A	3432474	3	1	21	1	0	0	0	0	1	0	0	0	3961	1116	39	1	9414	1	CSMD1	8	3432474	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08		3432474	142931548	62	4532											
ADHFE1	137872	broad.mit.edu	37	chr8	67372555	67372555	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcttctaggagccgacacccGcactgccaggatccaagatg	10	7	10	14	2	2	1	0	0	2	1	3	4	3	3	4	2	2	1	4	2	2	2	rs144952353		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr8:67372555G>A	uc003xwb.3	+	13	1209	c.1175G>A	c.(1174-1176)CGC>CAC	p.R392H	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Missense_Mutation_p.R344H|ADHFE1_uc003xwe.3_RNA|ADHFE1_uc003xwf.3_RNA|ADHFE1_uc011les.1_Missense_Mutation_p.R322H	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	392					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			GCCGACACCCGCACTGCCAGG	0.517											OREG0018808	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	155					0	0	0	0	A	67372555	A	A	67372555	3	1	21	1	0	0	0	0	1	0	0	0	314	1087	38	1	1225	1	ADHFE1	8	67372555	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	63940081	67372555	78991467	63	4533											
EXT1	2131	broad.mit.edu	37	chr8	118847731	118847731	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acggcagcttggttccaattAatcacttcagagaatggcaa	13	10	9	9	1	2	1	2	0	0	1	3	2	3	1	1	3	1	4	1	3	4	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr8:118847731A>T	uc003yok.1	-	3	1889	c.1116T>A	c.(1114-1116)ATT>ATA	p.I372I		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	372	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			GGTTCCAATTAATCACTTCAG	0.507			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				4	94					0	0	0	0	T	118847731	T	T	118847731	2	4	21	1	0	0	0	0	0	0	0	1	5348	358	13	5		5	EXT1	8	118847731	Silent	SNP	A	TCGA-BA-7269-01A-11D-2012-08	51475176	118847731	27516291	64	4534											
CDKN2A	1029	broad.mit.edu	37	chr9	21974678	21974678	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagaccctctacccaccTggatcggcctccgaccgtaa	8	7	8	18	3	1	1	0	0	1	1	3	3	2	2	6	2	2	2	6	2	2	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr9:21974678T>C	uc003zpk.2	-	1	361	c.149A>G	c.(148-150)CAG>CGG	p.Q50R	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Missense_Mutation_p.Q50R|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	50	ANK 2.		Q -> R (in CMM2).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(25)|p.Q50*(5)|p.Q50R(1)|p.V28_V51del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCTACCCACCTGGATCGGCCT	0.682		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			94	81					0	0	0	0	C	21974678	C	C	21974678	3	2	21	1	0	0	0	0	1	0	0	0	3176	1594	55	5	534	5	CDKN2A	9	21974678	Missense_Mutation	SNP	T	TCGA-BA-7269-01A-11D-2012-08		21974678	119238753	65	4535											
GCNT1	2650	broad.mit.edu	37	chr9	79117750	79117750	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgcctcagaatttctattgCattcatgtggacacaaaatc	13	13	6	9	0	3	1	2	0	1	1	4	2	3	2	1	1	2	1	1	1	4	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr9:79117750C>T	uc010mpf.2	+	3	794	c.453C>T	c.(451-453)TGC>TGT	p.C151C	GCNT1_uc010mpg.2_Silent_p.C151C|GCNT1_uc010mph.2_Silent_p.C151C|GCNT1_uc004akf.3_Silent_p.C151C|GCNT1_uc010mpi.2_Silent_p.C151C|GCNT1_uc004akh.3_Silent_p.C151C	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	151	Lumenal (Potential).|Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						ATTTCTATTGCATTCATGTGG	0.443													22	35					0	0	0	0	T	79117750	T	T	79117750	2	4	21	1	0	0	0	0	0	0	0	1	6335	718	25	4		4	GCNT1	9	79117750	Silent	SNP	C	TCGA-BA-7269-01A-11D-2012-08	57143072	79117750	62095681	66	4536											
NOL8	55035	broad.mit.edu	37	chr9	95064013	95064013	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgtagtttggaatatttCtttcagatccatagcaatat	11	19	6	5	0	2	1	1	0	1	1	3	2	3	2	1	1	1	3	1	1	6	9			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr9:95064013C>G	uc004arv.2	-	13	3332	c.2995G>C	c.(2995-2997)GAA>CAA	p.E999Q	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Missense_Mutation_p.E231Q|NOL8_uc011ltw.1_Missense_Mutation_p.E931Q	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	999					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						TGGAATATTTCTTTCAGATCC	0.388													5	11					0	0	0	0	G	95064013	G	G	95064013	3	3	21	1	0	0	0	0	1	0	0	0	10581	922	32	2	528	2	NOL8	9	95064013	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	15946263	95064013	46149418	67	4537											
PCGF5	84333	broad.mit.edu	37	chr10	93038049	93038049	+	Nonsense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccctatggtactgcagtaTcgaccaagaattgatttcgg	11	12	9	9	2	0	2	0	1	0	1	2	3	0	2	2	2	3	3	2	2	6	6			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr10:93038049T>G	uc001khh.2	+	10	994	c.747T>G	c.(745-747)TAT>TAG	p.Y249*	PCGF5_uc010qnk.1_Nonsense_Mutation_p.Y249*|PCGF5_uc001khi.2_Nonsense_Mutation_p.Y249*	NM_032373	NP_115749	Q86SE9	PCGF5_HUMAN	polycomb group ring finger 5	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|PcG protein complex	zinc ion binding			lung(1)	1						TACTGCAGTATCGACCAAGAA	0.358													4	24					0	0	0	0	G	93038049	G	G	93038049	4	3	21	1	0	0	0	0	0	1	0	0	11631	1442	50	5	781	5	PCGF5	10	93038049	Nonsense_Mutation	SNP	T	TCGA-BA-7269-01A-11D-2012-08		93038049	42496698	68	4538											
IDE	3416	broad.mit.edu	37	chr10	94294475	94294475	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttagggtatttctttgtTcccaaaaaaagcatatgttc	11	17	6	7	0	2	0	0	0	2	0	4	0	3	0	1	1	1	4	1	1	6	8			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr10:94294475T>C	uc001kia.2	-	3	427	c.351A>G	c.(349-351)GGA>GGG	p.G117G		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	117					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATTTCTTTGTTCCCAAAAAAA	0.348													28	36					0	0	0	0	C	94294475	C	C	94294475	2	2	21	1	0	0	0	0	0	0	0	1	7532	1770	62	5		5	IDE	10	94294475	Silent	SNP	T	TCGA-BA-7269-01A-11D-2012-08	1256426	94294475	41240272	69	4539											
CALHM1	255022	broad.mit.edu	37	chr10	105218230	105218230	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacatgtagcgcaacacagcGgggtccttggcccggcggcc	8	5	14	14	4	0	0	0	0	0	0	1	0	1	0	3	5	4	2	3	5	3	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr10:105218230G>A	uc001kxe.2	-	1	419	c.279C>T	c.(277-279)CCC>CCT	p.P93P		NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	93						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1						GCAACACAGCGGGGTCCTTGG	0.642													17	26					0	0	0	0	A	105218230	A	A	105218230	2	1	21	1	0	0	0	0	0	0	0	1	2594	1103	39	1		1	CALHM1	10	105218230	Silent	SNP	G	TCGA-BA-7269-01A-11D-2012-08	10923755	105218230	30316517	70	4540											
VENTX	27287	broad.mit.edu	37	chr10	135053283	135053283	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtcttccagcaccaccagtaCctgagccctctggagcggaa	9	7	10	15	1	2	1	0	1	2	0	3	3	3	3	5	2	4	2	5	2	2	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr10:135053283C>G	uc010quy.1	+	2	356	c.345C>G	c.(343-345)TAC>TAG	p.Y115*		NM_014468	NP_055283	O95231	VENTX_HUMAN	VENT homeobox	115	Homeobox.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		ACCACCAGTACCTGAGCCCTC	0.502													27	33					0	0	0	0	G	135053283	G	G	135053283	4	3	21	1	0	0	0	0	0	1	0	0	17221	518	18	4	351	4	VENTX	10	135053283	Nonsense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	29835053	135053283	481464	71	4541											
AHNAK	79026	broad.mit.edu	37	chr11	62296954	62296954	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgggggccttgaaatgcatCtcaggcatcttaaacttggg	9	12	12	8	0	2	1	1	1	2	0	3	1	2	1	1	4	2	2	1	4	3	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr11:62296954C>A	uc001ntl.2	-	5	5235	c.4935G>T	c.(4933-4935)GAG>GAT	p.E1645D	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1645					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGAAATGCATCTCAGGCATCT	0.468													71	224					8.73484e-25	1.0939e-24	1	0	A	62296954	A	A	62296954	3	1	21	1	0	0	0	0	1	0	0	0	414	912	32	2	12857	2	AHNAK	11	62296954	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08		62296954	72709562	72	4542											
RTN3	10313	broad.mit.edu	37	chr11	63488185	63488185	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actccagtagcatctcttgaCttagaacaagaacagctcac	14	9	6	12	0	2	3	1	1	1	2	4	3	3	3	1	0	4	3	1	0	5	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr11:63488185C>A	uc001nxq.2	+	3	2398	c.2211C>A	c.(2209-2211)GAC>GAA	p.D737E	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Missense_Mutation_p.D718E|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Missense_Mutation_p.D625E|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	737					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						CATCTCTTGACTTAGAACAAG	0.423													17	26					5.3912e-06	5.87334e-06	1	0	A	63488185	A	A	63488185	3	1	21	1	0	0	0	0	1	0	0	0	13792	564	20	4	2221	4	RTN3	11	63488185	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	1191231	63488185	71518331	73	4543											
PTPN6	5777	broad.mit.edu	37	chr12	7065324	7065324	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttgaccacagccgagtgatCctgcagggacgggacagtaa	11	6	14	10	2	0	2	0	2	0	0	1	5	1	4	3	2	2	3	3	2	1	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr12:7065324C>T	uc001qsb.2	+	8	1106	c.864C>T	c.(862-864)ATC>ATT	p.I288I	PTPN6_uc001qsa.1_Silent_p.I290I|PTPN6_uc010sfr.1_Silent_p.I249I|PTPN6_uc009zfl.1_Silent_p.I288I|PTPN6_uc010sfs.1_Silent_p.I276I	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	288	Tyrosine-protein phosphatase.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						GCCGAGTGATCCTGCAGGGAC	0.612													14	34					0	0	0	0	T	7065324	T	T	7065324	2	4	21	1	0	0	0	0	0	0	0	1	12857	845	30	2		2	PTPN6	12	7065324	Silent	SNP	C	TCGA-BA-7269-01A-11D-2012-08		7065324	126786571	74	4544											
USP15	9958	broad.mit.edu	37	chr12	62715344	62715344	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taacacatttgaaccactgaAtaaaccagacagcaccattc	17	8	4	12	0	0	3	0	2	0	1	1	3	0	3	3	0	4	1	3	0	5	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr12:62715344A>G	uc001src.1	+	5	584	c.575A>G	c.(574-576)AAT>AGT	p.N192S	USP15_uc001srb.1_Missense_Mutation_p.N192S|USP15_uc001sra.2_Missense_Mutation_p.N192S	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	192					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GAACCACTGAATAAACCAGAC	0.338													8	19					0	0	0	0	G	62715344	G	G	62715344	3	3	21	1	0	0	0	0	1	0	0	0	17114	101	4	5	593	5	USP15	12	62715344	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	55650020	62715344	71136551	75	4545											
E2F7	144455	broad.mit.edu	37	chr12	77439832	77439832	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actcacaagagggacagtcgGgttcagagaaatccagtaac	15	6	11	9	1	2	2	2	0	0	2	4	4	3	3	1	2	1	2	1	2	3	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr12:77439832G>T	uc001sym.3	-	5	1051	c.815C>A	c.(814-816)CCC>CAC	p.P272H	E2F7_uc001syn.2_Missense_Mutation_p.P272H	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	272					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						GGGACAGTCGGGTTCAGAGAA	0.433													12	34					0.000978159	0.00101607	1	0	T	77439832	T	T	77439832	3	4	21	1	0	0	0	0	1	0	0	0	4894	1232	43	4	1956	4	E2F7	12	77439832	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	14724488	77439832	56412063	76	4546											
SACS	26278	broad.mit.edu	37	chr13	23942586	23942586	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatcttctcaaaatgtccttGagaaaatcaacaagtggtgg	14	12	8	7	0	3	1	2	1	2	1	5	2	4	1	1	2	1	0	1	2	7	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr13:23942586G>C	uc001uon.2	-	5	889	c.300C>G	c.(298-300)CTC>CTG	p.L100L	SACS_uc001uoo.2_5'UTR|SACS_uc001uoq.1_5'UTR	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	100					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAATGTCCTTGAGAAAATCAA	0.373													5	13					0	0	0	0	C	23942586	C	C	23942586	2	2	21	1	0	0	0	0	0	0	0	1	13869	1277	45	2		2	SACS	13	23942586	Silent	SNP	G	TCGA-BA-7269-01A-11D-2012-08		23942586	91227292	77	4547											
KLHL1	57626	broad.mit.edu	37	chr13	70549922	70549922	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaggtgtcattgaatggccGgttgatgacagcctataaac	11	11	12	7	1	1	4	1	4	0	0	1	4	1	4	2	3	2	1	2	3	4	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr13:70549922G>A	uc001vip.2	-	2	1304	c.510C>T	c.(508-510)ACC>ACT	p.T170T	KLHL1_uc010thm.1_Intron	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	170					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TTGAATGGCCGGTTGATGACA	0.318													3	30					0	0	0	0	A	70549922	A	A	70549922	2	1	21	1	0	0	0	0	0	0	0	1	8404	1103	39	1		1	KLHL1	13	70549922	Silent	SNP	G	TCGA-BA-7269-01A-11D-2012-08	46607336	70549922	44619956	78	4548											
ARHGAP5	394	broad.mit.edu	37	chr14	32560503	32560516	+	Frame_Shift_Del	DEL	AGAGAAGTTCAGGC	-	-																															aatgcgtggatcattatcttAgagaagttcaggcatttgct																										TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr14:32560503_32560516delAGAGAAGTTCAGGC	uc001wrl.2	+	2	867_880	c.628_641delAGAGAAGTTCAGGC	c.(628-642)AGAGAAGTTCAGGCAfs	p.R210fs	ARHGAP5_uc001wrm.2_Frame_Shift_Del_p.R210fs|ARHGAP5_uc001wrn.2_Frame_Shift_Del_p.R210fs|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	210_214					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TCATTATCTTAGAGAAGTTCAGGCATTTGCTTCA	0.322													---	---	---								-	32560516	-	-	32560503	7	5	21	1	0	1	0	1	0	0	0	0	886	412	15	0	630	0	ARHGAP5	14	32560503	Frame_Shift_Del	DEL	AGAGAAGTTCAGGC	TCGA-BA-7269-01A-11D-2012-08		32560503	74789037	79	4549											
CLEC14A	161198	broad.mit.edu	37	chr14	38724915	38724915	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgcaaaggctcgttctccaGggtgcagtgggaacgcctgc	7	7	14	13	3	1	0	0	0	1	0	3	1	1	1	3	3	3	4	3	3	2	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr14:38724915G>A	uc001wum.1	-	1	660	c.313C>T	c.(313-315)CTG>TTG	p.L105L		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	105	Extracellular (Potential).|C-type lectin.					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TCGTTCTCCAGGGTGCAGTGG	0.692													3	8					0	0	0	0	A	38724915	A	A	38724915	2	1	21	1	0	0	0	0	0	0	0	1	3514	991	35	4		4	CLEC14A	14	38724915	Silent	SNP	G	TCGA-BA-7269-01A-11D-2012-08	6164412	38724915	68624625	80	4550											
FLRT2	23768	broad.mit.edu	37	chr14	86088851	86088851	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaaatatatcccttcatcTctcaacgtgcggggtttcat	9	14	6	12	2	5	0	4	0	1	0	7	0	6	0	1	2	2	1	1	2	4	4			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr14:86088851T>C	uc001xvr.2	+	2	1760	c.993T>C	c.(991-993)TCT>TCC	p.S331S	FLRT2_uc010atd.2_Silent_p.S331S	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	331	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TCCCTTCATCTCTCAACGTGC	0.488													38	216					0	0	0	0	C	86088851	C	C	86088851	2	2	21	1	0	0	0	0	0	0	0	1	5971	1538	54	5		5	FLRT2	14	86088851	Silent	SNP	T	TCGA-BA-7269-01A-11D-2012-08	47363936	86088851	21260689	81	4551											
MAP1A	4130	broad.mit.edu	37	chr15	43821107	43821107	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctagtaggaagaggggggcGgcgccgggtaggggggccag	7	3	24	7	3	0	1	0	0	0	1	0	2	0	2	2	9	0	3	2	9	4	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr15:43821107G>A	uc001zrt.2	+	4	7903	c.7436G>A	c.(7435-7437)CGG>CAG	p.R2479Q		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2479						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGAGGGGGGCGGCGCCGGGTA	0.622													17	33					0	0	0	0	A	43821107	A	A	43821107	3	1	21	1	0	0	0	0	1	0	0	0	9280	1116	39	1	7438	1	MAP1A	15	43821107	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08		43821107	58710285	82	4552											
SGK269	79834	broad.mit.edu	37	chr15	77474216	77474216	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttaggtttaaagcaattcTtgcattcaccaggtttccaa	11	16	6	8	0	2	0	1	0	1	0	3	0	3	0	2	2	2	4	2	2	5	8			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr15:77474216T>C	uc002bcm.2	-	3	361	c.53A>G	c.(52-54)AAG>AGG	p.K18R	SGK269_uc002bcn.2_Missense_Mutation_p.K18R	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	18					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		AAAGCAATTCTTGCATTCACC	0.408													23	43					0	0	0	0	C	77474216	C	C	77474216	3	2	21	1	0	0	0	0	1	0	0	0	14276	1609	56	5	5203	5	SGK269	15	77474216	Missense_Mutation	SNP	T	TCGA-BA-7269-01A-11D-2012-08	33653109	77474216	25057176	83	4553											
ANKS3	124401	broad.mit.edu	37	chr16	4774826	4774826	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagggagtaaatccacatatCggctccctgcaagatgtggg	12	8	12	9	1	0	1	0	0	0	1	3	2	2	2	2	3	1	3	2	3	5	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:4774826C>T	uc002cxj.1	-	6	793	c.498G>A	c.(496-498)CCG>CCA	p.P166P	ANKS3_uc002cxi.1_Silent_p.P93P|ANKS3_uc002cxk.2_Silent_p.P37P|ANKS3_uc002cxl.2_5'UTR|ANKS3_uc010uxs.1_Silent_p.P93P|ANKS3_uc002cxm.2_Intron	NM_133450	NP_597707	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain	166											0						ATCCACATATCGGCTCCCTGC	0.488													6	16					0	0	0	0	T	4774826	T	T	4774826	2	4	21	1	0	0	0	0	0	0	0	1	690	871	31	1		1	ANKS3	16	4774826	Silent	SNP	C	TCGA-BA-7269-01A-11D-2012-08		4774826	85579927	84	4554											
C16orf71	146562	broad.mit.edu	37	chr16	4793097	4793097	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagagtctggcgggacaagaAgacaaccagggaaatcgtgc	14	4	14	9	2	1	3	0	0	1	3	2	5	1	5	1	3	2	0	1	3	4	0			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:4793097A>C	uc002cxn.2	+	5	1299	c.837A>C	c.(835-837)GAA>GAC	p.E279D		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	279										central_nervous_system(1)	1						CGGGACAAGAAGACAACCAGG	0.527													28	52					0	0	0	0	C	4793097	C	C	4793097	3	2	21	1	0	0	0	0	1	0	0	0	1836	69	3	5	851	5	C16orf71	16	4793097	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	18271	4793097	85561656	85	4555											
NFATC2IP	84901	broad.mit.edu	37	chr16	28975123	28975123	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgatgggacaaagctttcagGcagggagctgccagctgacc	10	7	14	10	0	1	2	1	2	0	0	1	4	1	4	2	3	4	4	2	3	1	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:28975123G>T	uc002dru.2	+	8	1214	c.1199G>T	c.(1198-1200)GGC>GTC	p.G400V	uc010vct.1_Intron|NFATC2IP_uc002drt.2_Missense_Mutation_p.G121V|NFATC2IP_uc002drv.2_Missense_Mutation_p.G119V|NFATC2IP_uc010vdh.1_Missense_Mutation_p.G108V	NM_032815	NP_116204	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells,	400	Ubiquitin-like.					cytoplasm|nucleus				ovary(1)	1						AAGCTTTCAGGCAGGGAGCTG	0.587													9	29					0.000442599	0.000463346	1	0	T	28975123	T	T	28975123	3	4	21	1	0	0	0	0	1	0	0	0	10417	1203	42	4	1229	4	NFATC2IP	16	28975123	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	24182026	28975123	61379630	86	4556											
CDH11	1009	broad.mit.edu	37	chr16	64984856	64984856	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgctgatcactatgggcaGaaggtacaagtcctgcttct	10	11	10	10	1	2	2	1	1	1	1	4	2	3	2	1	2	2	4	1	2	4	3	rs142957030		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:64984856G>A	uc002eoi.2	-	12	2142	c.1708C>T	c.(1708-1710)CTG>TTG	p.L570L	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.L570L|CDH11_uc010vin.1_Silent_p.L444L	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	570	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ACTATGGGCAGAAGGTACAAG	0.612			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			15	33					0	0	0	0	A	64984856	A	A	64984856	2	1	21	1	0	0	0	0	0	0	0	1	3112	933	33	2		2	CDH11	16	64984856	Silent	SNP	G	TCGA-BA-7269-01A-11D-2012-08	36009733	64984856	25369897	87	4557											
RANBP10	57610	broad.mit.edu	37	chr16	67761784	67761784	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccccgcagagctgccgcCgaggatgcctgtcatctgca	6	7	12	16	3	2	1	1	0	1	1	2	3	2	2	5	1	5	3	5	1	0	0			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr16:67761784C>T	uc002eud.2	-	12	1606	c.1490G>A	c.(1489-1491)CGG>CAG	p.R497Q	RANBP10_uc010ceo.2_Missense_Mutation_p.R268Q|RANBP10_uc010vju.1_Missense_Mutation_p.R471Q|RANBP10_uc010vjv.1_Missense_Mutation_p.R410Q|RANBP10_uc010vjw.1_Missense_Mutation_p.R188Q	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	497										ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		GAGCTGCCGCCGAGGATGCCT	0.622													12	29					0	0	0	0	T	67761784	T	T	67761784	3	4	21	1	0	0	0	0	1	0	0	0	13091	652	23	1	384	1	RANBP10	16	67761784	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	2776928	67761784	22592969	88	4558											
TP53	7157	broad.mit.edu	37	chr17	7578180	7578181	+	Frame_Shift_Ins	INS	-	T	T																															cagttgcaaaccagacctcaINSggcggctcatagggcaccac																								rs138983188		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr17:7578180_7578181insT	uc002gim.2	-	6	862_863	c.668_669insA	c.(667-669)CCTfs	p.P223fs	TP53_uc002gig.1_Frame_Shift_Ins_p.P223fs|TP53_uc002gih.2_Frame_Shift_Ins_p.P223fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.P91fs|TP53_uc010cng.1_Frame_Shift_Ins_p.P91fs|TP53_uc002gii.1_Frame_Shift_Ins_p.P91fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.P223fs|TP53_uc010cni.1_Frame_Shift_Ins_p.P223fs|TP53_uc002gij.2_Frame_Shift_Ins_p.P223fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Ins_p.P130fs|TP53_uc002gio.2_Frame_Shift_Ins_p.P91fs|TP53_uc010vug.1_Frame_Shift_Ins_p.P184fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	223	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> L (in sporadic cancers; somatic mutation).|P -> T (in a sporadic cancer; somatic mutation).|P -> A (in a sporadic cancer; somatic mutation).|P -> S (in a sporadic cancer; somatic mutation).|P -> R (in a sporadic cancer; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.P223P(4)|p.P223L(4)|p.?(2)|p.P223H(2)|p.Y220_P223delYEPP(1)|p.P223S(1)|p.E224fs*5(1)|p.V218_E224delVPYEPPE(1)|p.P223A(1)|p.P223fs*24(1)|p.P223R(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACCAGACCTCAGGCGGCTCATA	0.535		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								T	7578181	T	T	7578180	7	5	21	1	0	1	1	0	0	0	0	0	16448	175	7	0	625	0	TP53	17	7578180	Frame_Shift_Ins	INS	-	TCGA-BA-7269-01A-11D-2012-08		7578180	73617030	89	4559											
RAI1	10743	broad.mit.edu	37	chr17	17697704	17697704	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagcataaaagccagcactGcagccccgaagggagcggct	12	3	13	13	2	0	0	0	0	0	0	0	2	0	1	3	2	6	5	3	2	3	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr17:17697704G>T	uc002grm.2	+	3	1911	c.1442G>T	c.(1441-1443)TGC>TTC	p.C481F	RAI1_uc002grn.1_Missense_Mutation_p.C481F	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	481						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		AGCCAGCACTGCAGCCCCGAA	0.652													19	66					4.63292e-17	5.49391e-17	1	0	T	17697704	T	T	17697704	3	4	21	1	0	0	0	0	1	0	0	0	13072	1319	46	4	1444	4	RAI1	17	17697704	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	10119524	17697704	63497506	90	4560											
CDC6	990	broad.mit.edu	37	chr17	38450241	38450241	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atggatcaactggacagcaaAggccaggatgtattgtacac	14	8	11	8	0	1	0	1	0	0	0	1	3	1	3	1	4	3	3	1	4	4	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr17:38450241A>G	uc002huj.1	+	6	1086	c.876A>G	c.(874-876)AAA>AAG	p.K292K		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	292					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						TGGACAGCAAAGGCCAGGATG	0.393													24	79					0	0	0	0	G	38450241	G	G	38450241	2	3	21	1	0	0	0	0	0	0	0	1	3098	69	3	5		5	CDC6	17	38450241	Silent	SNP	A	TCGA-BA-7269-01A-11D-2012-08	20752537	38450241	42744969	91	4561											
DSEL	92126	broad.mit.edu	37	chr18	65180850	65180850	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccataaaaccaattataattGgaatctgctatacccacagt	16	11	4	10	0	1	0	0	0	1	0	1	1	1	1	3	1	3	1	3	1	8	6			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr18:65180850G>T	uc002lke.1	-	2	2250	c.1026C>A	c.(1024-1026)TCC>TCA	p.S342S		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	332						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				AATTATAATTGGAATCTGCTA	0.363													13	56					4.3838e-07	4.89524e-07	1	0	T	65180850	T	T	65180850	2	4	21	1	0	0	0	0	0	0	0	1	4797	1335	47	4		4	DSEL	18	65180850	Silent	SNP	G	TCGA-BA-7269-01A-11D-2012-08		65180850	12896398	92	4562											
KEAP1	9817	broad.mit.edu	37	chr19	10597411	10597411	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccccactccggcccgatgTcattcgggtcacctcgctcc	5	8	8	20	4	2	0	2	0	0	0	6	1	4	0	6	2	0	1	6	2	0	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:10597411T>C	uc002moq.1	-	6	1948	c.1792A>G	c.(1792-1794)ACA>GCA	p.T598A	KEAP1_uc002mop.1_Missense_Mutation_p.T257A|KEAP1_uc002mor.1_Missense_Mutation_p.T598A	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	598	Kelch 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CGGCCCGATGTCATTCGGGTC	0.567													47	44					0	0	0	0	C	10597411	C	C	10597411	3	2	21	1	0	0	0	0	1	0	0	0	8180	1667	58	5	86	5	KEAP1	19	10597411	Missense_Mutation	SNP	T	TCGA-BA-7269-01A-11D-2012-08		10597411	48531572	93	4563											
ZNF709	163051	broad.mit.edu	37	chr19	12575387	12575387	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggctttaccacactgtttaCattcatagggtttctctcca	9	15	6	11	0	2	0	1	0	1	0	4	0	3	0	2	2	2	3	2	2	3	7			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:12575387C>A	uc002mtv.3	-	4	1510	c.1349G>T	c.(1348-1350)TGT>TTT	p.C450F	ZNF709_uc002mtw.3_Missense_Mutation_p.C418F|ZNF709_uc002mtx.3_Missense_Mutation_p.C450F	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	450	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACACTGTTTACATTCATAGGG	0.403													27	82					4.87955e-14	5.73562e-14	1	0	A	12575387	A	A	12575387	3	1	21	1	0	0	0	0	1	0	0	0	18180	478	17	4	580	4	ZNF709	19	12575387	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	1977976	12575387	46553596	94	4564											
ZNF302	55900	broad.mit.edu	37	chr19	35175566	35175566	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acatgcagtgaatgtgggaaAgcctttggcaaacagtcaat	14	9	11	7	0	1	1	1	1	0	0	1	2	1	2	1	2	3	2	1	2	4	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:35175566A>G	uc002nvr.1	+	6	1019	c.756A>G	c.(754-756)AAA>AAG	p.K252K	ZNF302_uc002nvp.1_Silent_p.K208K|ZNF302_uc002nvq.1_Silent_p.K208K|ZNF302_uc002nvs.1_Silent_p.K208K	NM_018443	NP_060913	Q9NR11	ZN302_HUMAN	zinc finger protein 302	287	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			AATGTGGGAAAGCCTTTGGCA	0.438													54	60					0	0	0	0	G	35175566	G	G	35175566	2	3	21	1	0	0	0	0	0	0	0	1	17899	69	3	5		5	ZNF302	19	35175566	Silent	SNP	A	TCGA-BA-7269-01A-11D-2012-08	22600179	35175566	23953417	95	4565											
AXL	558	broad.mit.edu	37	chr19	41749592	41749592	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgcgcaagtcctacagtcGtcggaccactgaagctacct	9	8	10	14	4	0	1	0	1	0	0	3	2	1	2	3	1	4	2	3	1	4	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:41749592G>A	uc010ehj.2	+	12	1707	c.1517G>A	c.(1516-1518)CGT>CAT	p.R506H	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Missense_Mutation_p.R506H|AXL_uc010ehk.2_Missense_Mutation_p.R497H	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	506	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						TCCTACAGTCGTCGGACCACT	0.562													38	72					0	0	0	0	A	41749592	A	A	41749592	3	1	21	1	0	0	0	0	1	0	0	0	1240	1145	40	1	1563	1	AXL	19	41749592	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	6574026	41749592	17379391	96	4566											
SLC8A2	6543	broad.mit.edu	37	chr19	47941206	47941206	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccgagcctcctcctcctcgGctgttagcttcctgtcccca	3	12	7	19	2	0	0	0	0	0	0	7	1	6	0	8	1	2	3	8	1	1	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:47941206G>A	uc002pgx.2	-	7	2188	c.1910C>T	c.(1909-1911)GCC>GTC	p.A637V	SLC8A2_uc010xyq.1_Missense_Mutation_p.A393V|SLC8A2_uc010xyr.1_Missense_Mutation_p.A100V|SLC8A2_uc010ele.2_Missense_Mutation_p.A637V	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	637	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CTCCTCCTCGGCTGTTAGCTT	0.567													27	101					0	0	0	0	A	47941206	A	A	47941206	3	1	21	1	0	0	0	0	1	0	0	0	14771	1203	42	4	871	4	SLC8A2	19	47941206	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	6191614	47941206	11187777	97	4567											
SIGLEC11	114132	broad.mit.edu	37	chr19	50463939	50463939	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaaggagcagctccctttGccgggatccccagtgagctg	8	7	12	14	1	0	1	0	1	0	0	2	3	2	3	5	2	4	3	5	2	1	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:50463939G>A	uc010ybh.1	-	2	421	c.330C>T	c.(328-330)GGC>GGT	p.G110G	SIGLEC11_uc010ybi.1_Silent_p.G110G	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	110	Ig-like V-type.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		AGCTCCCTTTGCCGGGATCCC	0.587													11	87					0	0	0	0	A	50463939	A	A	50463939	2	1	21	1	0	0	0	0	0	0	0	1	14372	1306	46	4		4	SIGLEC11	19	50463939	Silent	SNP	G	TCGA-BA-7269-01A-11D-2012-08	2522733	50463939	8665044	98	4568											
BRSK1	84446	broad.mit.edu	37	chr19	55823324	55823324	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctgctggtgccccaccccGaagcctgcagcccccacccg	5	4	10	22	2	0	0	0	0	0	0	0	1	0	0	9	1	5	2	9	1	1	0			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr19:55823324G>A	uc002qkg.2	+	19	2502	c.2225G>A	c.(2224-2226)CGA>CAA	p.R742Q	BRSK1_uc002qkf.2_Missense_Mutation_p.R758Q|BRSK1_uc002qkh.2_Missense_Mutation_p.R437Q	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	742					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GCCCCACCCCGAAGCCTGCAG	0.697													5	17					0	0	0	0	A	55823324	A	A	55823324	3	1	21	1	0	0	0	0	1	0	0	0	1528	1058	37	1	2299	1	BRSK1	19	55823324	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	5359385	55823324	3305659	99	4569											
SLC23A2	9962	broad.mit.edu	37	chr20	4880210	4880210	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccaatctcacctgcatccaAacgttgtctgtagcaaagta	12	10	6	13	1	2	0	1	0	2	0	4	0	3	0	3	0	3	5	3	0	5	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr20:4880210A>G	uc002wlg.1	-	6	848	c.473T>C	c.(472-474)TTT>TCT	p.F158S	SLC23A2_uc010zqr.1_Missense_Mutation_p.F157S|SLC23A2_uc002wlh.1_Missense_Mutation_p.F158S|SLC23A2_uc002wli.2_Missense_Mutation_p.F157S	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	158	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						CCTGCATCCAAACGTTGTCTG	0.552													71	176					0	0	0	0	G	4880210	G	G	4880210	3	3	21	1	0	0	0	0	1	0	0	0	14527	14	1	5	1527	5	SLC23A2	20	4880210	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08		4880210	58145310	100	4570											
XRN2	22803	broad.mit.edu	37	chr20	21312236	21312236	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtgctcctggtgaaggagAacataaaatcatggattaca	15	10	10	6	0	1	2	1	1	0	1	2	4	2	3	1	3	3	1	1	3	6	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr20:21312236A>G	uc002wsf.1	+	7	709	c.614A>G	c.(613-615)GAA>GGA	p.E205G	XRN2_uc002wsg.1_Missense_Mutation_p.E129G|XRN2_uc010zsk.1_Missense_Mutation_p.E151G	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	205					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						GGTGAAGGAGAACATAAAATC	0.289													16	36					0	0	0	0	G	21312236	G	G	21312236	3	3	21	1	0	0	0	0	1	0	0	0	17528	246	9	5	640	5	XRN2	20	21312236	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	16432026	21312236	41713284	101	4571											
MRPL39	54148	broad.mit.edu	37	chr21	26978860	26978860	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacttctatcttctcagttcGgggagttaatgataactgcc	10	14	8	9	1	3	1	1	1	3	0	5	2	3	2	1	2	3	2	1	2	4	6			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr21:26978860G>C	uc002ylo.2	-	2	195	c.181C>G	c.(181-183)CGA>GGA	p.R61G	MRPL39_uc002yln.2_Missense_Mutation_p.R61G	NM_017446	NP_059142	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39 isoform a	61						mitochondrial ribosome	nucleotide binding				0						TTCTCAGTTCGGGGAGTTAAT	0.433													10	40					0	0	0	0	C	26978860	C	C	26978860	3	2	21	1	0	0	0	0	1	0	0	0	9855	1124	39	3	964	3	MRPL39	21	26978860	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08		26978860	21151035	102	4572											
APP	351	broad.mit.edu	37	chr21	27394285	27394285	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcaccatcctcatcgtcctCgtcatcatcggcttcttctt	6	15	4	16	3	6	0	4	0	2	0	11	0	8	0	3	1	0	1	3	1	0	3	rs147485129		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr21:27394285C>T	uc002ylz.2	-	6	936	c.736G>A	c.(736-738)GAG>AAG	p.E246K	APP_uc010glk.2_Missense_Mutation_p.E241K|APP_uc002yma.2_Missense_Mutation_p.E246K|APP_uc011ach.1_Missense_Mutation_p.E190K|APP_uc002ymb.2_Missense_Mutation_p.E246K|APP_uc010glj.2_Missense_Mutation_p.E190K|APP_uc011aci.1_Missense_Mutation_p.E211K|APP_uc011acj.1_Missense_Mutation_p.E246K	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	246	Extracellular (Potential).|Asp/Glu-rich (acidic).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				tcatcgtcctcgtcatcatcg	0.114													9	35					0	0	0	0	T	27394285	T	T	27394285	3	4	21	1	0	0	0	0	1	0	0	0	815	893	31	1	1628	1	APP	21	27394285	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	415425	27394285	20735610	103	4573											
NEFH	4744	broad.mit.edu	37	chr22	29879403	29879403	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcagccaaggtgaacaCagacgctatgcgctcagcgc	11	4	14	12	3	1	2	1	1	0	1	1	3	1	3	1	3	4	3	1	3	3	1			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr22:29879403C>T	uc003afo.2	+	2	994	c.923C>T	c.(922-924)ACA>ATA	p.T308I		NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	308	Coil 2B.|Rod.				cell death|nervous system development	neurofilament					0						AAGGTGAACACAGACGCTATG	0.597													56	271					0	0	0	0	T	29879403	T	T	29879403	3	4	21	1	0	0	0	0	1	0	0	0	10368	478	17	4	929	4	NEFH	22	29879403	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08		29879403	21425163	104	4574											
SSTR3	6753	broad.mit.edu	37	chr22	37603361	37603361	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acacagccgcgctgaccgtgCgggccaccggagctgtgcgc	6	4	15	16	6	0	1	0	1	0	0	0	2	0	2	4	2	4	2	4	2	0	0			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr22:37603361C>T	uc003ara.2	-	2	544	c.482G>A	c.(481-483)CGC>CAC	p.R161H	SSTR3_uc003arb.2_Missense_Mutation_p.R161H	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	161	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						GCTGACCGTGCGGGCCACCGG	0.682													53	59					0	0	0	0	T	37603361	T	T	37603361	3	4	21	1	0	0	0	0	1	0	0	0	15265	768	27	1	778	1	SSTR3	22	37603361	Missense_Mutation	SNP	C	TCGA-BA-7269-01A-11D-2012-08	7723958	37603361	13701205	105	4575											
APOBEC3B	9582	broad.mit.edu	37	chr22	39387518	39387518	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttccttcaggagaacacacAcgtgagactgcgcatcttcg	10	9	10	12	3	2	2	1	1	1	2	4	4	3	2	1	1	2	2	1	1	1	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chr22:39387518A>G	uc003awo.1	+	6	959	c.905A>G	c.(904-906)CAC>CGC	p.H302R	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Missense_Mutation_p.H277R|APOBEC3B_uc003awq.1_RNA|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	302					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					GAGAACACACACGTGAGACTG	0.597													14	212					0	0	0	0	G	39387518	G	G	39387518	3	3	21	1	0	0	0	0	1	0	0	0	790	159	6	5	927	5	APOBEC3B	22	39387518	Missense_Mutation	SNP	A	TCGA-BA-7269-01A-11D-2012-08	1784157	39387518	11917048	106	4576											
DMD	1756	broad.mit.edu	37	chrX	31854842	31854842	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgcttcattaccttcactGgctgagtggctggtttttcc	4	17	10	10	0	2	1	2	1	0	0	3	1	3	1	2	3	2	5	2	3	1	6			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chrX:31854842G>T	uc004dda.1	-	49	7437	c.7193C>A	c.(7192-7194)CCA>CAA	p.P2398Q	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.P1054Q|DMD_uc004dcx.2_Missense_Mutation_p.P1057Q|DMD_uc004dcz.2_Missense_Mutation_p.P2275Q|DMD_uc004dcy.1_Missense_Mutation_p.P2394Q|DMD_uc004ddb.1_Missense_Mutation_p.P2390Q|DMD_uc004ddd.1_5'UTR	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2398					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TACCTTCACTGGCTGAGTGGC	0.423													23	16					1.36565e-18	1.6636e-18	1	0	T	31854842	T	T	31854842	3	4	21	1	0	0	0	0	1	0	0	0	4602	1348	47	4	4136	4	DMD	23	31854842	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08		31854842	123415718	107	4577											
SRPX	8406	broad.mit.edu	37	chrX	38079976	38079978	+	In_Frame_Del	DEL	GCA	-	-																															gctgcggctgggcgggacgcGcagcagcagcagcagcagca																								rs72249350		TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chrX:38079976_38079978delGCA	uc004ddy.1	-	1	154_156	c.68_70delTGC	c.(67-72)CTGCGC>CGC	p.L23del	SRPX_uc004ddz.1_In_Frame_Del_p.L23del|SRPX_uc011mkh.1_In_Frame_Del_p.L23del|SRPX_uc011mki.1_In_Frame_Del_p.L23del	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	23			Missing.		cell adhesion	cell surface|membrane					0						GGCGGGACGCgcagcagcagcag	0.576											OREG0019726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	38079978	-	-	38079976	7	5	21	1	0	1	0	1	0	0	0	0	15230	1087	38	0	1364	0	SRPX	23	38079976	In_Frame_Del	DEL	GCA	TCGA-BA-7269-01A-11D-2012-08	6225134	38079976	117190584	108	4578											
CSTF2	1478	broad.mit.edu	37	chrX	100078983	100078983	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgatgagaattgtggatccgGaaattgccctggtgagtgct	9	12	14	6	1	0	3	0	3	0	1	1	6	1	5	2	3	2	1	2	3	2	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chrX:100078983G>A	uc004egh.2	+	5	611	c.553G>A	c.(553-555)GAA>AAA	p.E185K	CSTF2_uc010nnd.2_Missense_Mutation_p.E185K|CSTF2_uc004egi.2_Missense_Mutation_p.E185K	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	185	Interactions with CSTF3 and SYMPK.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						TGTGGATCCGGAAATTGCCCT	0.468													23	45					0	0	0	0	A	100078983	A	A	100078983	3	1	21	1	0	0	0	0	1	0	0	0	4001	1175	41	2	571	2	CSTF2	23	100078983	Missense_Mutation	SNP	G	TCGA-BA-7269-01A-11D-2012-08	61999007	100078983	55191577	109	4579											
DCAF12L1	139170	broad.mit.edu	37	chrX	125685719	125685719	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcctggatagtgcgctcccGgctttccacaggtggaagta	8	9	13	11	2	0	0	0	0	0	0	2	2	2	2	3	4	2	3	3	4	3	3			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chrX:125685719G>A	uc004eul.2	-	1	1124	c.873C>T	c.(871-873)GCC>GCT	p.A291A		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	291	WD 3.									skin(3)|ovary(1)	4						GTGCGCTCCCGGCTTTCCACA	0.607													15	30					0	0	0	0	A	125685719	A	A	125685719	2	1	21	1	0	0	0	0	0	0	0	1	4281	1103	39	1		1	DCAF12L1	23	125685719	Silent	SNP	G	TCGA-BA-7269-01A-11D-2012-08	25606736	125685719	29584841	110	4580											
ZNF185	7739	broad.mit.edu	37	chrX	152113985	152113985	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcggatctgagcaacttgtCagacgagagagttgtggcag	11	8	15	7	2	2	3	1	1	1	2	2	6	2	4	0	2	3	3	0	2	1	2			TCGA-BA-7269-01A-11D-2012-08	TCGA-BA-7269-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2e8ffdfc-48f5-41e0-9192-d761f3b518ef	da077b22-a2b5-4b29-bb44-692e5eb09f28	g.chrX:152113985C>T	uc010ntv.1	+	16	1420	c.1383C>T	c.(1381-1383)GTC>GTT	p.V461V	ZNF185_uc011myg.1_Silent_p.V493V|ZNF185_uc011myh.1_Silent_p.V464V|ZNF185_uc011myi.1_Silent_p.V432V|ZNF185_uc011myj.1_Silent_p.V402V|ZNF185_uc011myk.1_Silent_p.V462V|ZNF185_uc004fgw.3_Silent_p.V240V|ZNF185_uc004fgu.2_Silent_p.V90V|ZNF185_uc004fgv.2_Silent_p.V158V|ZNF185_uc004fgx.2_Silent_p.V99V	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	461						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGCAACTTGTCAGACGAGAGA	0.607													6	3					0	0	0	0	T	152113985	T	T	152113985	2	4	21	1	0	0	0	0	0	0	0	1	17819	813	29	2		2	ZNF185	23	152113985	Silent	SNP	C	TCGA-BA-7269-01A-11D-2012-08	26428266	152113985	3156575	111	4581											
PER3	8863	broad.mit.edu	37	chr1	7880227	7880227	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaagaaagtgtatctcctgtAcaaatacaacttcttcctcc	14	12	4	11	0	2	1	0	0	2	1	5	1	4	1	3	0	3	2	3	0	7	5			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr1:7880227A>T	uc001aoo.2	+	14	1862	c.1687A>T	c.(1687-1689)ACA>TCA	p.T563S	PER3_uc009vmg.1_Missense_Mutation_p.T571S|PER3_uc009vmh.1_Missense_Mutation_p.T564S|PER3_uc001aop.2_Missense_Mutation_p.T571S|PER3_uc010nzw.1_Missense_Mutation_p.T252S	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	563	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TATCTCCTGTACAAATACAAC	0.398													5	59					0	0	0	0	T	7880227	T	T	7880227	3	4	22	1	0	0	0	0	1	0	0	0	11785	391	14	5	1741	5	PER3	1	7880227	Missense_Mutation	SNP	A	TCGA-BB-4217-01A-11D-2078-08		7880227	241370394	1	4582											
ASH1L	55870	broad.mit.edu	37	chr1	155319129	155319129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaaaatacctcagcattccGaaagactttgagcatgtcag	15	9	8	9	1	2	2	2	1	0	1	3	4	3	2	2	0	3	2	2	0	4	3			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr1:155319129G>A	uc009wqq.2	-	19	8038	c.7558C>T	c.(7558-7560)CGG>TGG	p.R2520W	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.R2515W|MIR555_hsa-mir-555|MI0003561_5'Flank	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2520	Bromo.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TCAGCATTCCGAAAGACTTTG	0.383													7	57					0	0	0	0	A	155319129	A	A	155319129	3	1	22	1	0	0	0	0	1	0	0	0	1043	1057	37	1	1391	1	ASH1L	1	155319129	Missense_Mutation	SNP	G	TCGA-BB-4217-01A-11D-2078-08	147438902	155319129	93931492	2	4583											
LTBP1	4052	broad.mit.edu	37	chr2	33567941	33567941	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacaacactgtttgtgacaGtcacgggttttgtgacaata	13	12	9	7	1	1	2	1	2	0	0	1	2	1	2	0	1	2	2	0	1	4	4			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:33567941G>A	uc002ros.2	+	25	3770	c.3770G>A	c.(3769-3771)AGT>AAT	p.S1257N	LTBP1_uc002rot.2_Missense_Mutation_p.S931N|LTBP1_uc002rou.2_Missense_Mutation_p.S930N|LTBP1_uc002rov.2_Missense_Mutation_p.S877N|LTBP1_uc010ymz.1_Intron|LTBP1_uc010yna.1_Intron|LTBP1_uc010ynb.1_Intron	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1256	EGF-like 13; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GTTTGTGACAGTCACGGGTTT	0.443													6	46					0	0	0	0	A	33567941	A	A	33567941	3	1	22	1	0	0	0	0	1	0	0	0	9123	1029	36	4	3920	4	LTBP1	2	33567941	Missense_Mutation	SNP	G	TCGA-BB-4217-01A-11D-2078-08		33567941	209631432	3	4584											
LRP1B	53353	broad.mit.edu	37	chr2	141243044	141243044	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagaccaatagaggttttttCcaatccaatcgacagcaagt	14	10	7	10	1	0	2	0	0	0	2	3	3	2	2	3	1	1	2	3	1	5	4			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:141243044C>T	uc002tvj.1	-	59	10265	c.9293G>A	c.(9292-9294)GGA>GAA	p.G3098E		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3098	Extracellular (Potential).|LDL-receptor class B 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAGGTTTTTTCCAATCCAATC	0.373										TSP Lung(27;0.18)			5	35					0	0	0	0	T	141243044	T	T	141243044	3	4	22	1	0	0	0	0	1	0	0	0	9005	855	30	2	4638	2	LRP1B	2	141243044	Missense_Mutation	SNP	C	TCGA-BB-4217-01A-11D-2078-08	107675103	141243044	101956329	4	4585											
CCDC148	130940	broad.mit.edu	37	chr2	159170404	159170404	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcttcacttagttgacagTttctagaagcaacaaaaatg	14	13	6	8	0	3	2	1	1	2	1	3	2	3	2	0	0	2	3	0	0	6	6			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr2:159170404T>C	uc002tzq.2	-	8	1030	c.767A>G	c.(766-768)AAC>AGC	p.N256S	CCDC148_uc002tzr.2_Missense_Mutation_p.N104S|CCDC148_uc010foh.2_5'UTR|CCDC148_uc010foi.1_Missense_Mutation_p.N203S|CCDC148_uc010foj.1_Missense_Mutation_p.N104S|CCDC148_uc010fok.1_Missense_Mutation_p.N170S	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	256										ovary(2)	2						TAGTTGACAGTTTCTAGAAGC	0.388													4	46					0	0	0	0	C	159170404	C	C	159170404	3	2	22	1	0	0	0	0	1	0	0	0	2794	1725	60	5	1088	5	CCDC148	2	159170404	Missense_Mutation	SNP	T	TCGA-BB-4217-01A-11D-2078-08	17927360	159170404	84028969	5	4586											
WDR82	80335	broad.mit.edu	37	chr3	52304734	52304734	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaggcttgcttaccgtctaTtttgttagagctgtaaacaa	12	14	8	7	1	1	1	0	0	1	1	1	1	1	1	1	1	4	5	1	1	7	7			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:52304734T>C	uc003ddl.2	-	2	535	c.253A>G	c.(253-255)ATA>GTA	p.I85V	WDR82_uc003ddk.2_5'Flank|uc011bee.1_5'Flank|MIRLET7G_hsa-let-7g|MI0000433_5'Flank	NM_025222	NP_079498	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	85					histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding				0				BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		TTACCGTCTATTTTGTTAGAG	0.378													7	134					0	0	0	0	C	52304734	C	C	52304734	3	2	22	1	0	0	0	0	1	0	0	0	17399	1493	52	5	720	5	WDR82	3	52304734	Missense_Mutation	SNP	T	TCGA-BB-4217-01A-11D-2078-08		52304734	145717696	6	4587											
KPNA4	3840	broad.mit.edu	37	chr3	160227623	160227623	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actaattgttaagttacttaTggcccaagcagcttcttttt	10	17	6	8	0	1	0	0	0	1	0	1	0	1	0	1	1	3	4	1	1	5	8			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:160227623T>A	uc003fdn.2	-	14	1480	c.1174A>T	c.(1174-1176)ATA>TTA	p.I392L		NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4	392	ARM 8.|NLS binding site (minor) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			AAGTTACTTATGGCCCAAGCA	0.318													18	137					0	0	0	0	A	160227623	A	A	160227623	3	1	22	1	0	0	0	0	1	0	0	0	8471	1464	51	5	407	5	KPNA4	3	160227623	Missense_Mutation	SNP	T	TCGA-BB-4217-01A-11D-2078-08	107922889	160227623	37794807	7	4588											
ST6GAL1	6480	broad.mit.edu	37	chr3	186760908	186760908	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atcaagttcagtgcagaggcCctgcgctgccacctccggga	8	7	12	14	2	2	1	2	0	0	1	3	2	3	2	4	2	3	3	4	2	1	1			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr3:186760908C>T	uc003frb.2	+	4	849	c.417C>T	c.(415-417)GCC>GCT	p.A139A	ST6GAL1_uc003frc.2_Intron|ST6GAL1_uc003frd.2_Silent_p.A139A	NM_173216	NP_775323	P15907	SIAT1_HUMAN	ST6 beta-galactosamide	139	Lumenal (Potential).				humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)	1	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		GTGCAGAGGCCCTGCGCTGCC	0.507													8	52					0	0	0	0	T	186760908	T	T	186760908	2	4	22	1	0	0	0	0	0	0	0	1	15287	610	22	4		4	ST6GAL1	3	186760908	Silent	SNP	C	TCGA-BB-4217-01A-11D-2078-08	26533285	186760908	11261522	8	4589											
OTOP1	133060	broad.mit.edu	37	chr4	4214642	4214642	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgggaaaactccttcagTggctgataaacattctgaaa	14	10	9	8	0	2	2	1	2	1	0	3	4	3	3	1	2	2	1	1	2	5	3			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr4:4214642T>C	uc003ghp.1	-	2	523	c.493A>G	c.(493-495)ACT>GCT	p.T165A		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	165					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACTCCTTCAGTGGCTGATAAA	0.393													5	61					0	0	0	0	C	4214642	C	C	4214642	3	2	22	1	0	0	0	0	1	0	0	0	11359	1696	59	5	1365	5	OTOP1	4	4214642	Missense_Mutation	SNP	T	TCGA-BB-4217-01A-11D-2078-08		4214642	186939634	9	4590											
GABRA2	2555	broad.mit.edu	37	chr4	46307679	46307679	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcaacctgtactgaatcAgatgcattgtaagtccaaat	14	10	9	8	0	1	2	1	1	0	1	2	3	2	3	2	1	4	4	2	1	5	3			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr4:46307679A>G	uc003gxc.3	-	6	1282	c.609T>C	c.(607-609)TCT>TCC	p.S203S	GABRA2_uc010igc.2_Silent_p.S203S|GABRA2_uc011bzc.1_Silent_p.S148S|GABRA2_uc003gxe.2_Silent_p.S203S	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	203	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTACTGAATCAGATGCATTGT	0.358													4	63					0	0	0	0	G	46307679	G	G	46307679	2	3	22	1	0	0	0	0	0	0	0	1	6195	175	7	5		5	GABRA2	4	46307679	Silent	SNP	A	TCGA-BB-4217-01A-11D-2078-08	42093037	46307679	144846597	10	4591											
CDC20B	166979	broad.mit.edu	37	chr5	54420729	54420729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagtccatcactgcagcCgctggaaagcagcctgccat	10	6	10	15	1	1	0	1	0	0	0	2	1	2	1	4	1	6	4	4	1	1	0			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:54420729C>T	uc003jpo.1	-	9	1292	c.1117G>A	c.(1117-1119)GGC>AGC	p.G373S	CDC20B_uc003jpn.1_Missense_Mutation_p.G373S|CDC20B_uc010ivu.1_Missense_Mutation_p.G373S|CDC20B_uc010ivv.1_3'UTR	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	373	WD 4.										0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			TCACTGCAGCCGCTGGAAAGC	0.567													5	63					0	0	0	0	T	54420729	T	T	54420729	3	4	22	1	0	0	0	0	1	0	0	0	3075	652	23	1	458	1	CDC20B	5	54420729	Missense_Mutation	SNP	C	TCGA-BB-4217-01A-11D-2078-08		54420729	126494531	11	4592											
ZNF366	167465	broad.mit.edu	37	chr5	71739939	71739939	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agggctgtagggctccacctCgtagcagttatcctcctctt	6	12	10	13	1	1	0	0	0	1	0	5	0	4	0	4	2	1	6	4	2	3	4			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:71739939C>T	uc003kce.1	-	5	2065	c.1879G>A	c.(1879-1881)GAG>AAG	p.E627K		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	627					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GGCTCCACCTCGTAGCAGTTA	0.667													9	194					0	0	0	0	T	71739939	T	T	71739939	3	4	22	1	0	0	0	0	1	0	0	0	17937	893	31	1	359	1	ZNF366	5	71739939	Missense_Mutation	SNP	C	TCGA-BB-4217-01A-11D-2078-08	17319210	71739939	109175321	12	4593											
PCDHA3	56145	broad.mit.edu	37	chr5	140182956	140182956	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgctctgcggtgctccgCgccgccaaccgaaggcgact	6	7	12	16	6	1	0	0	0	1	0	2	2	2	0	4	2	5	2	4	2	3	1			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:140182956C>A	uc003lhf.2	+	1	2174	c.2174C>A	c.(2173-2175)GCG>GAG	p.A725E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.A725E	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	725	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGTGCTCCGCGCCGCCAACC	0.637													9	129					0.00829132	0.00829132	1	0	A	140182956	A	A	140182956	3	1	22	1	0	0	0	0	1	0	0	0	11579	768	27	3	2176	3	PCDHA3	5	140182956	Missense_Mutation	SNP	C	TCGA-BB-4217-01A-11D-2078-08	68443017	140182956	40732304	13	4594											
STK10	6793	broad.mit.edu	37	chr5	171488259	171488260	+	Frame_Shift_Del	DEL	AC	-	-																															ggtcctccttctgcttggctAcaaagtcccggtcctgtggg																										TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr5:171488259_171488260delAC	uc003mbo.1	-	14	2395_2396	c.2095_2096delGT	c.(2095-2097)GTAfs	p.V699fs		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	699	Potential.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTGCTTGGCTACAAAGTCCCGG	0.584													---	---	---								-	171488260	-	-	171488259	7	5	22	1	0	1	0	1	0	0	0	0	15352	391	14	0	834	0	STK10	5	171488259	Frame_Shift_Del	DEL	AC	TCGA-BB-4217-01A-11D-2078-08	31305303	171488259	9427001	14	4595											
LAMA4	3910	broad.mit.edu	37	chr6	112440499	112440499	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtcggccactgctcctttCtcgaataaatatcacctgga	10	11	7	13	2	2	0	1	0	1	0	5	2	3	1	3	2	1	1	3	2	4	3			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr6:112440499C>T	uc003pvu.2	-	34	4990	c.4681G>A	c.(4681-4683)GAA>AAA	p.E1561K	LAMA4_uc003pvv.2_Missense_Mutation_p.E1554K|LAMA4_uc003pvt.2_Missense_Mutation_p.E1554K	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1561	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CTGCTCCTTTCTCGAATAAAT	0.438													6	80					0	0	0	0	T	112440499	T	T	112440499	3	4	22	1	0	0	0	0	1	0	0	0	8648	922	32	2	814	2	LAMA4	6	112440499	Missense_Mutation	SNP	C	TCGA-BB-4217-01A-11D-2078-08		112440499	58674568	15	4596											
TMEM38B	55151	broad.mit.edu	37	chr9	108484899	108484900	+	Frame_Shift_Ins	INS	-	A	A																															gatgaatggctgaagatgtcINSatagtaagttggtataaatt																										TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr9:108484899_108484900insA	uc004bcu.1	+	4	656_657	c.539_540insA	c.(538-540)TCAfs	p.S180fs	TMEM38B_uc010mtn.1_Intron	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	180	Lumenal (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2						CTGAAGATGTCATAGTAAGTTG	0.342													---	---	---								A	108484900	A	A	108484899	7	5	22	1	0	1	1	0	0	0	0	0	16226	838	29	0	553	0	TMEM38B	9	108484899	Frame_Shift_Ins	INS	-	TCGA-BB-4217-01A-11D-2078-08		108484899	32728532	16	4597											
TTF1	7270	broad.mit.edu	37	chr9	135277018	135277018	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagacactcgtgcccttttGacagacgtaagcttcctttt	8	13	7	13	2	0	3	0	1	0	2	2	3	1	3	3	0	2	2	3	0	1	6			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr9:135277018G>A	uc004cbl.2	-	2	1243	c.1191C>T	c.(1189-1191)GTC>GTT	p.V397V	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	397					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		GTGCCCTTTTGACAGACGTAA	0.463													6	94					0	0	0	0	A	135277018	A	A	135277018	2	1	22	1	0	0	0	0	0	0	0	1	16786	1277	45	2		2	TTF1	9	135277018	Silent	SNP	G	TCGA-BB-4217-01A-11D-2078-08	26792119	135277018	5936413	17	4598											
HKDC1	80201	broad.mit.edu	37	chr10	71003038	71003038	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacacagagtggggggccttCggggacgacggggccctgga	8	4	19	10	3	0	1	0	0	0	1	1	4	0	3	2	8	1	0	2	8	1	1	rs138098227		TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr10:71003038C>T	uc001jpf.3	+	7	925	c.792C>T	c.(790-792)TTC>TTT	p.F264F	HKDC1_uc010qje.1_Silent_p.F127F	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	264					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						GGGGGGCCTTCGGGGACGACG	0.592													5	87					0	0	0	0	T	71003038	T	T	71003038	2	4	22	1	0	0	0	0	0	0	0	1	7232	883	31	1		1	HKDC1	10	71003038	Silent	SNP	C	TCGA-BB-4217-01A-11D-2078-08		71003038	64531709	18	4599											
TAF10	6881	broad.mit.edu	37	chr11	6632457	6632457	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agctgccggaggccgtgcccTtcattttgcagtgctgtagg	5	11	14	11	2	1	0	1	0	0	0	1	1	1	1	3	3	5	4	3	3	1	4			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr11:6632457T>C	uc001mej.1	-	4	555	c.530A>G	c.(529-531)AAG>AGG	p.K177R		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	177					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GGCCGTGCCCTTCATTTTGCA	0.488													5	64					0	0	0	0	C	6632457	C	C	6632457	3	2	22	1	0	0	0	0	1	0	0	0	15580	1609	56	5	134	5	TAF10	11	6632457	Missense_Mutation	SNP	T	TCGA-BB-4217-01A-11D-2078-08		6632457	128374059	19	4600											
C11orf48	79081	broad.mit.edu	37	chr11	62435132	62435134	+	In_Frame_Del	DEL	TCT	-	-																															cctcaagaatccaacaagcaTcttcttcatcctggtcctgc																										TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr11:62435132_62435134delTCT	uc001nue.2	-	4	834_836	c.399_401delAGA	c.(397-402)GAAGAT>GAT	p.E133del	C11orf48_uc001nuf.2_In_Frame_Del_p.E133del|METTL12_uc001nuh.2_3'UTR|C11orf48_uc010rmd.1_In_Frame_Del_p.E133del	NM_024099	NP_077004	Q9BQE6	CK048_HUMAN	hypothetical protein LOC79081	159											0						CCAACAAGCATCTTCTTCATCCT	0.537													---	---	---								-	62435134	-	-	62435132	7	5	22	1	0	1	0	1	0	0	0	0	1650	1435	50	0	406	0	C11orf48	11	62435132	In_Frame_Del	DEL	TCT	TCGA-BB-4217-01A-11D-2078-08	55802675	62435132	72571384	20	4601											
TAS2R30	259293	broad.mit.edu	37	chr12	11286073	11286073	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagaacatgaagacaggttgCttttccagcctcccaaaatt	13	10	7	11	0	0	3	0	1	0	2	2	3	2	3	3	1	3	2	3	1	4	4			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr12:11286073C>A	uc009zhs.1	-	1	771	c.771G>T	c.(769-771)AAG>AAT	p.K257N	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_001097643	NP_001091112			type 2 taste receptor member 30												0						AGACAGGTTGCTTTTCCAGCC	0.388													12	116					1.5842e-08	1.71265e-08	1	0	A	11286073	A	A	11286073	3	1	22	1	0	0	0	0	1	0	0	0	15639	796	28	4	192	4	TAS2R30	12	11286073	Missense_Mutation	SNP	C	TCGA-BB-4217-01A-11D-2078-08		11286073	122565822	21	4602											
EID3	493861	broad.mit.edu	37	chr12	104698633	104698633	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcaggaaacagggagttatAtctttgactttacaggagtg	12	11	13	5	0	1	1	0	1	1	0	1	4	1	4	0	4	2	2	0	4	4	5			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr12:104698633A>G	uc001tkw.2	+	1	1085	c.921A>G	c.(919-921)ATA>ATG	p.I307M	TXNRD1_uc010swk.1_Intron|TXNRD1_uc010swl.1_Intron|TXNRD1_uc010swm.1_Intron|TXNRD1_uc010swn.1_Intron|TXNRD1_uc010swo.1_Intron|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Intron|TXNRD1_uc001tku.2_Intron|TXNRD1_uc001tko.1_Intron|TXNRD1_uc001tkp.1_Intron|TXNRD1_uc001tkv.1_Intron	NM_001008394	NP_001008395	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0						AGGGAGTTATATCTTTGACTT	0.398													10	63					0	0	0	0	G	104698633	G	G	104698633	3	3	22	1	0	0	0	0	1	0	0	0	5011	439	16	5	923	5	EID3	12	104698633	Missense_Mutation	SNP	A	TCGA-BB-4217-01A-11D-2078-08	93412560	104698633	29153262	22	4603											
EPSTI1	94240	broad.mit.edu	37	chr13	43500540	43500540	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtctggcgattctgtgttcaGtttgctcaagaactcagcgg	7	13	12	9	2	5	1	3	0	2	1	5	2	5	1	0	2	3	3	0	2	2	3			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr13:43500540G>T	uc001uyw.1	-	7	665	c.589C>A	c.(589-591)CTG>ATG	p.L197M	EPSTI1_uc001uyx.1_Missense_Mutation_p.L197M	NM_001002264	NP_001002264	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 isoform 1	197										ovary(1)	1		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		TCTGTGTTCAGTTTGCTCAAG	0.428													12	170					0.00010058	0.000103159	1	0	T	43500540	T	T	43500540	3	4	22	1	0	0	0	0	1	0	0	0	5222	1020	36	4	671	4	EPSTI1	13	43500540	Missense_Mutation	SNP	G	TCGA-BB-4217-01A-11D-2078-08		43500540	71669338	23	4604											
PRKD1	5587	broad.mit.edu	37	chr14	30100144	30100144	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acatttgccgtagtgatttcGaaacaatgaggattggcccc	11	11	10	9	2	0	2	0	2	0	0	1	4	0	3	3	2	2	1	3	2	3	4			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr14:30100144G>A	uc001wqh.2	-	10	1657	c.1476C>T	c.(1474-1476)TTC>TTT	p.F492F		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	492	PH.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TAGTGATTTCGAAACAATGAG	0.398													7	80					0	0	0	0	A	30100144	A	A	30100144	2	1	22	1	0	0	0	0	0	0	0	1	12580	1049	37	1		1	PRKD1	14	30100144	Silent	SNP	G	TCGA-BB-4217-01A-11D-2078-08		30100144	77249396	24	4605											
GPX2	2877	broad.mit.edu	37	chr14	65406461	65406462	+	Frame_Shift_Del	DEL	CT	-	-																															tgctcgttctgcccattcacCtcacatttttggacaagggt																										TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr14:65406461_65406462delCT	uc010tsn.1	-	3	404_405	c.317_318delAG	c.(316-318)GAGfs	p.E106fs	CHURC1_uc010tsj.1_Intron|CHURC1_uc010tsk.1_Intron|FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|GPX2_uc001xhy.1_RNA	NM_002083	NP_002074	P18283	GPX2_HUMAN	glutathione peroxidase 2	106					response to oxidative stress	cytoplasm	electron carrier activity|glutathione peroxidase activity			ovary(1)	1				all cancers(60;0.00117)|OV - Ovarian serous cystadenocarcinoma(108;0.00557)|BRCA - Breast invasive adenocarcinoma(234;0.00971)	Glutathione(DB00143)	GCCCATTCACCTCACATTTTTG	0.525													---	---	---								-	65406462	-	-	65406461	7	5	22	1	0	1	0	1	0	0	0	0	6779	680	24	0	258	0	GPX2	14	65406461	Frame_Shift_Del	DEL	CT	TCGA-BB-4217-01A-11D-2078-08	35306317	65406461	41943079	25	4606											
SERPINA12	145264	broad.mit.edu	37	chr14	94956062	94956062	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagtcttcttcaggtcgaaGgtgcccgtcatgtggagtct	7	12	13	9	2	5	1	2	0	3	1	6	3	5	2	1	3	1	0	1	3	1	2			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr14:94956062G>A	uc001ydj.2	-	5	1744	c.948C>T	c.(946-948)ACC>ACT	p.T316T		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	316					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		TCAGGTCGAAGGTGCCCGTCA	0.532													5	50					0	0	0	0	A	94956062	A	A	94956062	2	1	22	1	0	0	0	0	0	0	0	1	14154	987	35	4		4	SERPINA12	14	94956062	Silent	SNP	G	TCGA-BB-4217-01A-11D-2078-08	29549601	94956062	12393478	26	4607											
LDHAL6B	92483	broad.mit.edu	37	chr15	59499318	59499318	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagagtgagcttattgagcGtttcacttccgagaagcccg	10	10	12	9	3	1	4	1	2	0	2	2	6	2	4	2	0	3	2	2	0	3	4			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr15:59499318G>A	uc002agb.2	+	1	277	c.179G>A	c.(178-180)CGT>CAT	p.R60H	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	60					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	CTTATTGAGCGTTTCACTTCC	0.552													5	78					0	0	0	0	A	59499318	A	A	59499318	3	1	22	1	0	0	0	0	1	0	0	0	8740	1145	40	1	181	1	LDHAL6B	15	59499318	Missense_Mutation	SNP	G	TCGA-BB-4217-01A-11D-2078-08		59499318	43032074	27	4608											
AGBL1	123624	broad.mit.edu	37	chr15	86810224	86810224	+	Frame_Shift_Del	DEL	T	-	-																															tccttatttcattgtaggccTttgcaagacaatgcttccaa																										TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr15:86810224delT	uc002blz.1	+	12	1697	c.1617delT	c.(1615-1617)CCTfs	p.P539fs	AGBL1_uc002bma.1_Frame_Shift_Del_p.P270fs|AGBL1_uc002bmb.1_Frame_Shift_Del_p.P233fs	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	539					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ATTGTAGGCCTTTGCAAGACA	0.323													---	---	---								-	86810224	-	-	86810224	7	5	22	1	0	1	0	1	0	0	0	0	375	1596	56	0	1659	0	AGBL1	15	86810224	Frame_Shift_Del	DEL	T	TCGA-BB-4217-01A-11D-2078-08	27310906	86810224	15721168	28	4609											
LOC100132247	100132247	broad.mit.edu	37	chr16	22545578	22545580	+	In_Frame_Del	DEL	ATA	-	-																															gcttccaccctcagcggatgAtaatctcaagacaccttccg																										TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr16:22545578_22545580delATA	uc010bxg.2	+	9	1456_1458	c.1274_1276delATA	c.(1273-1278)GATAAT>GAT	p.N426del	LOC100132247_uc010vbv.1_In_Frame_Del_p.N426del|LOC100132247_uc010vbw.1_In_Frame_Del_p.N426del|LOC100132247_uc010bxi.2_In_Frame_Del_p.N407del|LOC100132247_uc010bxk.2_In_Frame_Del_p.N243del	NM_001135865	NP_001129337	A8MRT5	K220L_HUMAN	hypothetical protein LOC100132247	426	Pro-rich.					integral to membrane					0						TCAGCGGATGATAATCTCAAGAC	0.586													---	---	---								-	22545580	-	-	22545578	7	5	22	1	0	1	0	1	0	0	0	0	8912	333	12	0	1300	0	LOC100132247	16	22545578	In_Frame_Del	DEL	ATA	TCGA-BB-4217-01A-11D-2078-08		22545578	67809175	29	4610											
PMFBP1	83449	broad.mit.edu	37	chr16	72159281	72159281	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctttgctgcaggctcttTgtctctgaggtcacgtgatt	6	15	11	9	1	3	2	1	2	2	0	4	2	3	2	0	2	3	4	0	2	1	3			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr16:72159281T>G	uc002fcc.3	-	16	2464	c.2292A>C	c.(2290-2292)ACA>ACC	p.T764T	PMFBP1_uc002fcd.2_Silent_p.T759T|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Silent_p.T614T|PMFBP1_uc010cgo.1_Silent_p.T55T	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	764	Potential.									ovary(2)	2		Ovarian(137;0.179)				GCAGGCTCTTTGTCTCTGAGG	0.483											OREG0023927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	170					0	0	0	0	G	72159281	G	G	72159281	2	3	22	1	0	0	0	0	0	0	0	1	12189	1799	63	5		5	PMFBP1	16	72159281	Silent	SNP	T	TCGA-BB-4217-01A-11D-2078-08	49613703	72159281	18195472	30	4611											
CNTNAP4	85445	broad.mit.edu	37	chr16	76556036	76556036	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaaccagtggcaccatgtGagggttgaaaggaacatgaa	15	6	13	7	0	0	3	0	3	0	0	0	5	0	4	2	3	2	2	2	3	4	1			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr16:76556036G>A	uc002feu.1	+	19	3022	c.2637G>A	c.(2635-2637)GTG>GTA	p.V879V	CNTNAP4_uc002fev.1_Silent_p.V743V|CNTNAP4_uc010chb.1_Silent_p.V806V|CNTNAP4_uc002fex.1_Silent_p.V882V	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	879	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GGCACCATGTGAGGGTTGAAA	0.527													6	120					0	0	0	0	A	76556036	A	A	76556036	2	1	22	1	0	0	0	0	0	0	0	1	3664	1277	45	2		2	CNTNAP4	16	76556036	Silent	SNP	G	TCGA-BB-4217-01A-11D-2078-08	4396755	76556036	13798717	31	4612											
TP53	7157	broad.mit.edu	37	chr17	7578457	7578457	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgtagatggccatggcgCggacgcgggtgccgggcggg	4	6	21	10	6	0	1	0	0	0	1	0	2	0	2	2	6	1	2	2	6	1	2			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr17:7578457C>A	uc002gim.2	-	5	667	c.473G>T	c.(472-474)CGC>CTC	p.R158L	TP53_uc002gig.1_Missense_Mutation_p.R158L|TP53_uc002gih.2_Missense_Mutation_p.R158L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26L|TP53_uc010cng.1_Missense_Mutation_p.R26L|TP53_uc002gii.1_Missense_Mutation_p.R26L|TP53_uc010cnh.1_Missense_Mutation_p.R158L|TP53_uc010cni.1_Missense_Mutation_p.R158L|TP53_uc002gij.2_Missense_Mutation_p.R158L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65L|TP53_uc002gio.2_Missense_Mutation_p.R26L|TP53_uc010vug.1_Missense_Mutation_p.R119L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	63					5.9392e-07	6.25179e-07	1	0	A	7578457	A	A	7578457	3	1	22	1	0	0	0	0	1	0	0	0	16448	768	27	3	825	3	TP53	17	7578457	Missense_Mutation	SNP	C	TCGA-BB-4217-01A-11D-2078-08		7578457	73616753	32	4613											
PGLYRP2	114770	broad.mit.edu	37	chr19	15587145	15587145	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acggtcgagccatcaggtgcCagcaccaccccatattcctt	9	8	8	16	2	1	0	1	0	0	0	3	1	2	0	6	2	3	1	6	2	1	3			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr19:15587145C>T	uc002nbf.3	-	2	469	c.336G>A	c.(334-336)CTG>CTA	p.L112L	PGLYRP2_uc002nbg.3_Silent_p.L112L	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	112					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						CATCAGGTGCCAGCACCACCC	0.617													9	105					0	0	0	0	T	15587145	T	T	15587145	2	4	22	1	0	0	0	0	0	0	0	1	11849	581	21	4		4	PGLYRP2	19	15587145	Silent	SNP	C	TCGA-BB-4217-01A-11D-2078-08		15587145	43541838	33	4614											
CACNA1I	8911	broad.mit.edu	37	chr22	40059771	40059771	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcccacaaactcttcgactaCgtcgtcctggccttcatctt	7	12	6	16	3	3	0	1	0	2	0	6	1	4	0	3	1	2	0	3	1	2	4			TCGA-BB-4217-01A-11D-2078-08	TCGA-BB-4217-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5916ef19-7838-4621-a869-de8c2b34931c	7a5278a1-1bf9-4dba-ade5-43dd3e0653ab	g.chr22:40059771C>T	uc003ayc.2	+	19	3522	c.3522C>T	c.(3520-3522)TAC>TAT	p.Y1174Y	CACNA1I_uc003ayd.2_Silent_p.Y1139Y|CACNA1I_uc003aye.2_Silent_p.Y1089Y|CACNA1I_uc003ayf.2_Silent_p.Y1054Y	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1174	Helical; Name=S1 of repeat III; (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TCTTCGACTACGTCGTCCTGG	0.632													9	96					0	0	0	0	T	40059771	T	T	40059771	2	4	22	1	0	0	0	0	0	0	0	1	2558	547	19	1		1	CACNA1I	22	40059771	Silent	SNP	C	TCGA-BB-4217-01A-11D-2078-08		40059771	11244795	34	4615											
PRKCZ	5590	broad.mit.edu	37	chr1	2080336	2080336	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacatttcctcatcccggaaGcatgacagcattaaagacga	14	9	7	11	2	1	2	1	1	0	1	3	4	3	3	2	1	3	2	2	1	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:2080336G>T	uc001aiq.2	+	8	821	c.660G>T	c.(658-660)AAG>AAT	p.K220N	PRKCZ_uc001air.2_Missense_Mutation_p.K37N|PRKCZ_uc010nyw.1_Missense_Mutation_p.K116N|PRKCZ_uc001ais.2_Missense_Mutation_p.K37N|PRKCZ_uc009vla.2_Missense_Mutation_p.K44N|PRKCZ_uc010nyx.1_RNA|PRKCZ_uc009vlb.2_Missense_Mutation_p.K33N	NM_002744	NP_002735	Q05513	KPCZ_HUMAN	protein kinase C, zeta isoform 1	220					anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CATCCCGGAAGCATGACAGCA	0.562													26	52					1.32181e-22	1.38925e-22	1	0	T	2080336	T	T	2080336	3	4	23	1	0	0	0	0	1	0	0	0	12579	962	34	4	690	4	PRKCZ	1	2080336	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08		2080336	247170285	1	4616											
CASZ1	54897	broad.mit.edu	37	chr1	10715871	10715871	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctgcttactcgtgaacctCtgccaggagacagcgccacg	8	8	10	15	3	1	2	0	1	1	1	3	3	2	2	4	1	5	1	4	1	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:10715871C>T	uc001aro.2	-	9	1821	c.1501_splice	c.e9-1	p.R501_splice	CASZ1_uc001arp.1_Splice_Site_p.R501_splice|CASZ1_uc009vmx.2_Splice_Site_p.R525_splice	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TCGTGAACCTCTGCCAGGAGA	0.632													4	85					0	0	0	0	T	10715871	T	T	10715871	5	4	23	1	0	0	0	0	0	0	1	0	2697	927	32	2	3835	2	CASZ1	1	10715871	Splice_Site	SNP	C	TCGA-BB-4223-01A-01D-1434-08	8635535	10715871	238534750	2	4617											
CLCN6	1185	broad.mit.edu	37	chr1	11896103	11896103	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtctctggtgagcatcCtgcgcaccacggtccaccat	7	9	9	16	2	1	1	0	1	1	0	5	1	4	1	5	2	2	2	5	2	0	0	rs7412854		TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:11896103C>T	uc001ate.3	+	18	1986	c.1873C>T	c.(1873-1875)CTG>TTG	p.L625L	CLCN6_uc010oat.1_Silent_p.L341L|CLCN6_uc010oau.1_Silent_p.L603L	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	625	Cytoplasmic (By similarity).|CBS 1.				cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGAGCATCCTGCGCACCAC	0.592													3	53					0	0	0	0	T	11896103	T	T	11896103	2	4	23	1	0	0	0	0	0	0	0	1	3482	680	24	4		4	CLCN6	1	11896103	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1180232	11896103	237354518	3	4618											
GMEB1	10691	broad.mit.edu	37	chr1	29029013	29029013	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagggctggaatggaactCagctctcaccgctgctgtca	8	8	13	12	1	3	0	3	0	1	0	4	2	3	2	1	4	3	5	1	4	2	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:29029013C>G	uc001bra.2	+	7	830	c.692C>G	c.(691-693)TCA>TGA	p.S231*	GMEB1_uc001bqz.2_Nonsense_Mutation_p.S221*|GMEB1_uc001brb.2_Nonsense_Mutation_p.S221*	NM_006582	NP_006573	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding	231					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		GAATGGAACTCAGCTCTCACC	0.488													5	104					0	0	0	0	G	29029013	G	G	29029013	4	3	23	1	0	0	0	0	0	1	0	0	6524	838	29	2	714	2	GMEB1	1	29029013	Nonsense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	17132910	29029013	220221608	4	4619											
CSMD2	114784	broad.mit.edu	37	chr1	33992840	33992840	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgggcagtgttgatgggtCtcccactgggccggacctct	4	9	14	14	2	2	1	0	1	2	0	3	2	2	2	4	4	0	2	4	4	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:33992840C>G	uc001bxn.1	-	64	9787	c.9758G>C	c.(9757-9759)AGA>ACA	p.R3253T	CSMD2_uc001bxm.1_Missense_Mutation_p.R3397T	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3253	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTTGATGGGTCTCCCACTGGG	0.507													4	138					0	0	0	0	G	33992840	G	G	33992840	3	3	23	1	0	0	0	0	1	0	0	0	3962	913	32	2	729	2	CSMD2	1	33992840	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	4963827	33992840	215257781	5	4620											
CLSPN	63967	broad.mit.edu	37	chr1	36226454	36226454	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttactatggtgatcactgttCatttcagtagtatttgcagt	9	18	8	6	0	3	1	3	1	0	0	3	1	3	1	0	1	2	4	0	1	4	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:36226454C>T	uc001bzi.2	-	8	1148	c.1068G>A	c.(1066-1068)ATG>ATA	p.M356I	CLSPN_uc009vux.2_Missense_Mutation_p.M356I	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	356					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GATCACTGTTCATTTCAGTAG	0.383													6	138					0	0	0	0	T	36226454	T	T	36226454	3	4	23	1	0	0	0	0	1	0	0	0	3575	826	29	2	3023	2	CLSPN	1	36226454	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2233614	36226454	213024167	6	4621											
CLSPN	63967	broad.mit.edu	37	chr1	36226773	36226773	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcatgaatggttttattctCaggcatatgatatggaaggt	12	15	10	4	0	2	2	2	2	1	0	3	3	2	3	0	4	0	2	0	4	5	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:36226773C>G	uc001bzi.2	-	7	1008	c.928G>C	c.(928-930)GAG>CAG	p.E310Q	CLSPN_uc009vux.2_Missense_Mutation_p.E310Q	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	310					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTTTTATTCTCAGGCATATGA	0.358													8	177					0	0	0	0	G	36226773	G	G	36226773	3	3	23	1	0	0	0	0	1	0	0	0	3575	835	29	2	3167	2	CLSPN	1	36226773	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	319	36226773	213023848	7	4622											
CLSPN	63967	broad.mit.edu	37	chr1	36228043	36228043	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgataactcacttccttcctCaaatgaatggaccccactct	11	12	4	14	0	3	2	2	2	1	0	5	3	5	3	4	1	1	0	4	1	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:36228043C>G	uc001bzi.2	-	5	864	c.784G>C	c.(784-786)GAG>CAG	p.E262Q	CLSPN_uc009vux.2_Missense_Mutation_p.E262Q	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	262					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTTCCTTCCTCAAATGAATGG	0.388													4	146					0	0	0	0	G	36228043	G	G	36228043	3	3	23	1	0	0	0	0	1	0	0	0	3575	835	29	2	3319	2	CLSPN	1	36228043	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1270	36228043	213022578	8	4623											
PPCS	79717	broad.mit.edu	37	chr1	42925418	42925418	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttggaaatttatcagcatCaagtggtggtggctaatatc	11	14	10	6	0	2	0	2	0	0	0	3	1	2	1	0	4	1	2	0	4	5	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:42925418C>G	uc001chl.2	+	3	821	c.757C>G	c.(757-759)CAA>GAA	p.Q253E	PPCS_uc001chk.2_Missense_Mutation_p.Q80E	NM_024664	NP_078940	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase isoform	253					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TTATCAGCATCAAGTGGTGGT	0.408													6	245					0	0	0	0	G	42925418	G	G	42925418	3	3	23	1	0	0	0	0	1	0	0	0	12360	827	29	2	767	2	PPCS	1	42925418	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	6697375	42925418	206325203	9	4624											
BEST4	266675	broad.mit.edu	37	chr1	45250344	45250344	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaatgagggccgcagagactCggccgccgtggccacagtgt	8	5	16	12	4	0	2	0	1	0	1	1	4	0	2	4	3	0	1	4	3	1	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:45250344C>T	uc001cmm.2	-	8	1154	c.1105G>A	c.(1105-1107)GAG>AAG	p.E369K		NM_153274	NP_695006	Q8NFU0	BEST4_HUMAN	bestrophin 4	369	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CGCAGAGACTCGGCCGCCGTG	0.657													5	27					0	0	0	0	T	45250344	T	T	45250344	3	4	23	1	0	0	0	0	1	0	0	0	1409	893	31	1	324	1	BEST4	1	45250344	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2324926	45250344	204000277	10	4625											
USP1	7398	broad.mit.edu	37	chr1	62908868	62908868	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttggcaagttatgaattGatatgcagtttacagtcctt	10	17	8	6	0	1	2	0	2	1	0	2	2	2	2	1	1	2	4	1	1	5	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:62908868G>A	uc001daj.1	+	5	763	c.435G>A	c.(433-435)TTG>TTA	p.L145L	USP1_uc001dak.1_Silent_p.L145L|USP1_uc001dal.1_Silent_p.L145L	NM_001017415	NP_001017415	O94782	UBP1_HUMAN	ubiquitin specific protease 1	145					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		GTTATGAATTGATATGCAGTT	0.358													7	201					0	0	0	0	A	62908868	A	A	62908868	2	1	23	1	0	0	0	0	0	0	0	1	17108	1281	45	2		2	USP1	1	62908868	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	17658524	62908868	186341753	11	4626											
IL23R	149233	broad.mit.edu	37	chr1	67635171	67635171	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttataaaaatggcatcaaaGaaagatttcaaatcacaagg	20	10	6	5	0	3	2	3	0	0	2	3	2	3	2	0	2	0	1	0	2	8	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:67635171G>C	uc001ddo.2	+	3	302	c.217G>C	c.(217-219)GAA>CAA	p.E73Q	IL23R_uc009waz.2_5'UTR|IL23R_uc001ddp.2_RNA|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_5'UTR|IL23R_uc010opk.1_Missense_Mutation_p.E30Q|IL23R_uc010opl.1_5'UTR|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_5'UTR|IL23R_uc010opn.1_5'UTR|IL23R_uc001ddr.2_RNA	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	73	Extracellular (Potential).				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						TGGCATCAAAGAAAGATTTCA	0.343													9	227					0	0	0	0	C	67635171	C	C	67635171	3	2	23	1	0	0	0	0	1	0	0	0	7715	943	33	2	223	2	IL23R	1	67635171	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4726303	67635171	181615450	12	4627											
LRRC7	57554	broad.mit.edu	37	chr1	70518708	70518708	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccataccatttttgcaataGaccccgtcccagcaaagcaa	13	8	6	14	1	0	1	0	0	0	1	1	1	1	1	5	0	4	3	5	0	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:70518708G>C	uc001dep.2	+	21	4027	c.3997_splice	c.e21-1	p.T1333_splice	LRRC7_uc009wbg.2_Splice_Site_p.T617_splice|LRRC7_uc001deq.2_Splice_Site_p.T527_splice	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7							centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TTTTGCAATAGACCCCGTCCC	0.393													8	196					0	0	0	0	C	70518708	C	C	70518708	5	2	23	1	0	0	0	0	0	0	1	0	9070	956	33	2	4078	2	LRRC7	1	70518708	Splice_Site	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2883537	70518708	178731913	13	4628											
ACADM	34	broad.mit.edu	37	chr1	76215195	76215195	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaatgttttaattggtgacgGagctggtttcaaagttgcaa	12	14	11	4	1	1	1	1	1	0	0	1	2	1	2	0	3	2	5	0	3	4	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:76215195G>A	uc001dgw.3	+	9	1230	c.800G>A	c.(799-801)GGA>GAA	p.G267E	ACADM_uc010ord.1_Missense_Mutation_p.G181E|ACADM_uc009wbp.2_Missense_Mutation_p.G271E|ACADM_uc009wbr.2_Missense_Mutation_p.G300E|ACADM_uc010ore.1_Missense_Mutation_p.G231E|ACADM_uc010orf.1_Missense_Mutation_p.G78E|ACADM_uc001dgx.3_Missense_Mutation_p.G181E|ACADM_uc010org.1_Missense_Mutation_p.G137E|ACADM_uc009wbs.1_RNA	NM_000016	NP_000007	P11310	ACADM_HUMAN	medium-chain acyl-CoA dehydrogenase isoform a	267			G -> R (in ACADMD).		carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4						ATTGGTGACGGAGCTGGTTTC	0.343													14	179					0	0	0	0	A	76215195	A	A	76215195	3	1	23	1	0	0	0	0	1	0	0	0	113	1174	41	2	846	2	ACADM	1	76215195	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	5696487	76215195	173035426	14	4629											
LRRC8C	84230	broad.mit.edu	37	chr1	90178478	90178478	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttataaatcagatgtgttatGagcgagccctccactggtat	11	13	9	8	1	1	2	1	1	0	1	2	3	2	2	2	1	2	2	2	1	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:90178478G>C	uc001dnl.3	+	3	591	c.349G>C	c.(349-351)GAG>CAG	p.E117Q		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	117						endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		GATGTGTTATGAGCGAGCCCT	0.453													8	222					0	0	0	0	C	90178478	C	C	90178478	3	2	23	1	0	0	0	0	1	0	0	0	9073	1291	45	2	355	2	LRRC8C	1	90178478	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	13963283	90178478	159072143	15	4630											
HFM1	164045	broad.mit.edu	37	chr1	91841220	91841220	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttctgaagtttcactggtCtatggctctcatccattttc	6	18	6	11	0	4	1	2	1	3	0	7	1	5	1	1	2	0	2	1	2	2	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:91841220C>G	uc001doa.3	-	12	1560	c.1460G>C	c.(1459-1461)AGA>ACA	p.R487T	HFM1_uc010osu.1_Missense_Mutation_p.R166T|HFM1_uc010osv.1_Missense_Mutation_p.R171T	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	487							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TTTCACTGGTCTATGGCTCTC	0.378													8	286					0	0	0	0	G	91841220	G	G	91841220	3	3	23	1	0	0	0	0	1	0	0	0	7122	913	32	2	2959	2	HFM1	1	91841220	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1662742	91841220	157409401	16	4631											
HIST2H2AB	317772	broad.mit.edu	37	chr1	149859462	149859462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccctgctttccgcgtcctGacattacggctaaaattgca	8	12	7	14	3	0	1	0	1	0	0	3	1	3	1	3	1	3	3	3	1	3	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:149859462G>A	uc001ete.2	-	1	5	c.5C>T	c.(4-6)TCA>TTA	p.S2L	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	2				S->A: Blocks the inhibition of transcription by RPS6KA5/MSK1.	nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TCCGCGTCCTGACATTACGGC	0.537													12	263					0	0	0	0	A	149859462	A	A	149859462	3	1	23	1	0	0	0	0	1	0	0	0	7216	1294	45	2	391	2	HIST2H2AB	1	149859462	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	58018242	149859462	99391159	17	4632											
PIP5K1A	8394	broad.mit.edu	37	chr1	151204833	151204833	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatttggtatccggcccgatGattacttggtaagcatctgg	8	14	11	8	2	1	1	0	1	1	0	2	2	2	1	2	4	2	3	2	4	4	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:151204833G>A	uc001exj.2	+	6	930	c.478G>A	c.(478-480)GAT>AAT	p.D160N	PIP5K1A_uc001exi.2_Missense_Mutation_p.D147N|PIP5K1A_uc010pcu.1_Missense_Mutation_p.D148N|PIP5K1A_uc001exk.2_Missense_Mutation_p.D147N|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	160	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCGGCCCGATGATTACTTGGT	0.498													9	284					0	0	0	0	A	151204833	A	A	151204833	3	1	23	1	0	0	0	0	1	0	0	0	11994	1290	45	2	500	2	PIP5K1A	1	151204833	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1345371	151204833	98045788	18	4633											
TCHH	7062	broad.mit.edu	37	chr1	152083217	152083217	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgcagctctttctccctctCgcgtcgctggcggcgccgct	1	11	11	18	6	3	0	0	0	3	0	6	0	3	0	2	2	2	4	2	2	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:152083217C>G	uc001ezp.2	-	2	2476	c.2476G>C	c.(2476-2478)GAG>CAG	p.E826Q	TCHH_uc009wne.1_Missense_Mutation_p.E826Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	826					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCTCCCTCTCGCGTCGCTGG	0.687													6	173					0	0	0	0	G	152083217	G	G	152083217	3	3	23	1	0	0	0	0	1	0	0	0	15766	893	31	3	3359	3	TCHH	1	152083217	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	878384	152083217	97167404	19	4634											
TCHH	7062	broad.mit.edu	37	chr1	152083788	152083788	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctcctcctgctcctcgctCttcagcagctgctggcgcct	2	12	8	19	2	3	0	1	0	2	0	7	0	5	0	4	1	4	5	4	1	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:152083788C>G	uc001ezp.2	-	2	1905	c.1905G>C	c.(1903-1905)AAG>AAC	p.K635N	TCHH_uc009wne.1_Missense_Mutation_p.K635N	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	635	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTCCTCGCTCTTCAGCAGCT	0.672													5	157					0	0	0	0	G	152083788	G	G	152083788	3	3	23	1	0	0	0	0	1	0	0	0	15766	912	32	2	3930	2	TCHH	1	152083788	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	571	152083788	97166833	20	4635											
FLG2	388698	broad.mit.edu	37	chr1	152323783	152323783	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtggactgtccatgaccaGactggccatgtctagtggta	8	11	13	9	0	1	2	0	1	1	1	2	3	2	3	3	3	0	1	3	3	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:152323783G>C	uc001ezw.3	-	3	6552	c.6479C>G	c.(6478-6480)TCT>TGT	p.S2160C	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2160	Filaggrin 10.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCATGACCAGACTGGCCATG	0.512													8	571					0	0	0	0	C	152323783	C	C	152323783	3	2	23	1	0	0	0	0	1	0	0	0	5955	942	33	2	700	2	FLG2	1	152323783	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	239995	152323783	96926838	21	4636											
SPRR2E	6704	broad.mit.edu	37	chr1	153066128	153066128	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttggtggtgggcagggctCagggcacttcgggggtggac	4	9	20	8	1	1	0	1	0	0	0	2	1	1	1	0	8	0	3	0	8	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:153066128C>G	uc001fbh.2	-	2	161	c.100G>C	c.(100-102)GAG>CAG	p.E34Q	SPRR2D_uc009wnz.2_Intron|SPRR2A_uc001fbf.2_Intron|SPRR2A_uc009woa.2_Intron	NM_001024209	NP_001019380	P22531	SPR2E_HUMAN	small proline-rich protein 2E	34	3 X 9 AA tandem repeats of P-K-C-P-[EQ]- P-C-P-P.|2.				keratinization	cornified envelope|cytoplasm	protein binding|structural molecule activity			ovary(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGCAGGGCTCAGGGCACTTC	0.617													10	531					0	0	0	0	G	153066128	G	G	153066128	3	3	23	1	0	0	0	0	1	0	0	0	15166	835	29	2	122	2	SPRR2E	1	153066128	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	742345	153066128	96184493	22	4637											
ASH1L	55870	broad.mit.edu	37	chr1	155327111	155327111	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatatttcctttttacctttCacgattggacattggcttca	8	18	6	9	1	2	0	2	0	0	0	3	3	3	1	2	2	1	1	2	2	2	9			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:155327111C>T	uc009wqq.2	-	15	7546	c.7066G>A	c.(7066-7068)GAA>AAA	p.E2356K	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.E2351K	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2356					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TTTTACCTTTCACGATTGGAC	0.363													6	159					0	0	0	0	T	155327111	T	T	155327111	3	4	23	1	0	0	0	0	1	0	0	0	1043	835	29	2	1899	2	ASH1L	1	155327111	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2260983	155327111	93923510	23	4638											
ASH1L	55870	broad.mit.edu	37	chr1	155448995	155448995	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctcaaaagaatgcctcctCtttttttgcccacaaaattt	11	15	4	11	0	2	1	1	0	1	1	3	1	3	1	3	0	3	1	3	0	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:155448995C>G	uc009wqq.2	-	3	4146	c.3666G>C	c.(3664-3666)AAG>AAC	p.K1222N	ASH1L_uc001fkt.2_Missense_Mutation_p.K1222N|ASH1L_uc009wqr.1_Missense_Mutation_p.K1222N	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1222					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			AATGCCTCCTCTTTTTTTGCC	0.413													85	206					0	0	0	0	G	155448995	G	G	155448995	3	3	23	1	0	0	0	0	1	0	0	0	1043	912	32	2	5332	2	ASH1L	1	155448995	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	121884	155448995	93801626	24	4639			1	6		5	5	780	C		2.332608e-10
ASH1L	55870	broad.mit.edu	37	chr1	155449016	155449016	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttttttgcccacaaaatttCtctgccctgtctgatgtgct	6	18	6	11	0	2	1	0	1	2	0	3	1	2	1	2	0	3	1	2	0	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:155449016C>G	uc009wqq.2	-	3	4125	c.3645G>C	c.(3643-3645)GAG>GAC	p.E1215D	ASH1L_uc001fkt.2_Missense_Mutation_p.E1215D|ASH1L_uc009wqr.1_Missense_Mutation_p.E1215D	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1215					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CACAAAATTTCTCTGCCCTGT	0.418													73	192					0	0	0	0	G	155449016	G	G	155449016	3	3	23	1	0	0	0	0	1	0	0	0	1043	912	32	2	5353	2	ASH1L	1	155449016	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	21	155449016	93801605	25	4640			1	6		5	5	780	C		2.332608e-10
ASH1L	55870	broad.mit.edu	37	chr1	155449680	155449680	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgattcaacagtttctttCtctttaaagtcttcatttta	9	21	3	8	0	6	1	2	1	4	0	7	1	6	1	0	0	1	1	0	0	4	8			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:155449680C>G	uc009wqq.2	-	3	3461	c.2981G>C	c.(2980-2982)AGA>ACA	p.R994T	ASH1L_uc001fkt.2_Missense_Mutation_p.R994T|ASH1L_uc009wqr.1_Missense_Mutation_p.R994T	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	994					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CAGTTTCTTTCTCTTTAAAGT	0.323													23	65					0	0	0	0	G	155449680	G	G	155449680	3	3	23	1	0	0	0	0	1	0	0	0	1043	913	32	2	6017	2	ASH1L	1	155449680	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	664	155449680	93800941	26	4641			1	6		5	5	780	C		2.332608e-10
ASH1L	55870	broad.mit.edu	37	chr1	155449745	155449745	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attaattgtccattgtttctCttggtaatttttttatctgg	7	23	6	5	0	2	0	0	0	2	0	4	0	3	0	1	2	0	2	1	2	3	10			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:155449745C>G	uc009wqq.2	-	3	3396	c.2916G>C	c.(2914-2916)AAG>AAC	p.K972N	ASH1L_uc001fkt.2_Missense_Mutation_p.K972N|ASH1L_uc009wqr.1_Missense_Mutation_p.K972N	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	972					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CATTGTTTCTCTTGGTAATTT	0.343													50	101					0	0	0	0	G	155449745	G	G	155449745	3	3	23	1	0	0	0	0	1	0	0	0	1043	912	32	2	6082	2	ASH1L	1	155449745	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	65	155449745	93800876	27	4642			1	6		5	5	780	C		2.332608e-10
ASH1L	55870	broad.mit.edu	37	chr1	155449774	155449774	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttttatctggttccatctCaaggtcactcatactacaga	10	16	5	10	0	4	1	3	0	2	1	6	1	5	1	1	2	2	1	1	2	4	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:155449774C>G	uc009wqq.2	-	3	3367	c.2887G>C	c.(2887-2889)GAG>CAG	p.E963Q	ASH1L_uc001fkt.2_Missense_Mutation_p.E963Q|ASH1L_uc009wqr.1_Missense_Mutation_p.E963Q	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	963					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GGTTCCATCTCAAGGTCACTC	0.353													76	150					0	0	0	0	G	155449774	G	G	155449774	3	3	23	1	0	0	0	0	1	0	0	0	1043	835	29	2	6111	2	ASH1L	1	155449774	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	29	155449774	93800847	28	4643			1	6		5	5	780	C		2.332608e-10
SEMA4A	64218	broad.mit.edu	37	chr1	156142792	156142792	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccatcttgtcatgtacctggGaaccagtgagtaaagagttc	11	11	10	9	0	2	2	1	1	1	1	3	3	2	3	3	1	2	3	3	1	4	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:156142792G>A	uc001fnl.2	+	11	1414	c.1310G>A	c.(1309-1311)GGA>GAA	p.G437E	SEMA4A_uc009wrq.2_Missense_Mutation_p.G437E|SEMA4A_uc001fnm.2_Missense_Mutation_p.G437E|SEMA4A_uc001fnn.2_Missense_Mutation_p.G305E|SEMA4A_uc001fno.2_Missense_Mutation_p.G437E	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	437	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					ATGTACCTGGGAACCAGTGAG	0.547													5	58					0	0	0	0	A	156142792	A	A	156142792	3	1	23	1	0	0	0	0	1	0	0	0	14096	1174	41	2	1348	2	SEMA4A	1	156142792	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	693018	156142792	93107829	29	4644											
IFI16	3428	broad.mit.edu	37	chr1	159002440	159002440	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagccatcttcggactcctCagatgccaccaacaactcca	12	7	6	16	1	2	2	1	0	1	2	5	3	4	3	5	1	4	0	5	1	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:159002440C>G	uc001ftg.2	+	7	1578	c.1288C>G	c.(1288-1290)CAG>GAG	p.Q430E	IFI16_uc010pis.1_Missense_Mutation_p.Q374E|IFI16_uc001fth.2_Missense_Mutation_p.Q29E|IFI16_uc010pit.1_Missense_Mutation_p.Q29E	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	430					cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					TCGGACTCCTCAGATGCCACC	0.512													11	188					0	0	0	0	G	159002440	G	G	159002440	3	3	23	1	0	0	0	0	1	0	0	0	7550	827	29	2	1310	2	IFI16	1	159002440	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2859648	159002440	90248181	30	4645											
ATP1A4	480	broad.mit.edu	37	chr1	160128899	160128899	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaccgagtccctgctgacctCcggcttatctctgcacaagg	7	9	10	15	2	1	1	0	1	1	0	4	3	3	1	4	2	2	3	4	2	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:160128899C>G	uc001fve.3	+	5	1112	c.633C>G	c.(631-633)CTC>CTG	p.L211L	ATP1A4_uc001fvf.3_RNA	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	211	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTGCTGACCTCCGGCTTATCT	0.532													5	132					0	0	0	0	G	160128899	G	G	160128899	2	3	23	1	0	0	0	0	0	0	0	1	1133	842	30	2		2	ATP1A4	1	160128899	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1126459	160128899	89121722	31	4646											
ATP1A4	480	broad.mit.edu	37	chr1	160147443	160147443	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgacctggaggacagctacGgacagcagtgggtgagtaga	12	6	16	7	1	0	3	0	2	0	1	0	6	0	6	1	4	3	3	1	4	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:160147443G>A	uc001fve.3	+	18	3204	c.2725G>A	c.(2725-2727)GGA>AGA	p.G909R	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.G412R|ATP1A4_uc001fvh.2_Missense_Mutation_p.G45R	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	909	Extracellular (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGACAGCTACGGACAGCAGTG	0.488													41	95					0	0	0	0	A	160147443	A	A	160147443	3	1	23	1	0	0	0	0	1	0	0	0	1133	1117	39	1	2795	1	ATP1A4	1	160147443	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	18544	160147443	89103178	32	4647											
FMO2	2327	broad.mit.edu	37	chr1	171178065	171178065	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctaaactggctgtgagactCtatttcggaccctgcaactc	9	11	8	13	1	1	1	0	1	1	1	3	3	1	2	2	2	3	2	2	2	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:171178065C>G	uc001ghk.1	+	9	1506	c.1389C>G	c.(1387-1389)CTC>CTG	p.L463L	FMO2_uc010pmd.1_Silent_p.L243L	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	463					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTGTGAGACTCTATTTCGGAC	0.478													14	533					0	0	0	0	G	171178065	G	G	171178065	2	3	23	1	0	0	0	0	0	0	0	1	5987	900	32	2		2	FMO2	1	171178065	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	11030622	171178065	78072556	33	4648											
TNFSF4	7292	broad.mit.edu	37	chr1	173155684	173155684	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagaattcaccaggattttGatggataagaatcagttctc	14	12	8	7	0	3	3	2	1	1	2	4	5	3	5	1	2	0	1	1	2	3	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:173155684G>C	uc001giw.2	-	3	679	c.523C>G	c.(523-525)CAA>GAA	p.Q175E	TNFSF4_uc001giv.2_Missense_Mutation_p.Q125E	NM_003326	NP_003317	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily,	175	Extracellular (Potential).				acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			central_nervous_system(1)	1						CCAGGATTTTGATGGATAAGA	0.468													4	117					0	0	0	0	C	173155684	C	C	173155684	3	2	23	1	0	0	0	0	1	0	0	0	16376	1299	45	2	32	2	TNFSF4	1	173155684	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1977619	173155684	76094937	34	4649											
ASTN1	460	broad.mit.edu	37	chr1	176993782	176993782	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacgagagggcagttgacgtGagaggagcacacgaggccaa	14	3	16	8	3	0	3	0	2	0	2	0	7	0	4	1	3	2	3	1	3	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:176993782G>C	uc001glc.2	-	6	1419	c.1207C>G	c.(1207-1209)CAC>GAC	p.H403D	ASTN1_uc001glb.1_Missense_Mutation_p.H403D|ASTN1_uc001gld.1_Missense_Mutation_p.H403D|ASTN1_uc009wwx.1_Missense_Mutation_p.H403D|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	403					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CAGTTGACGTGAGAGGAGCAC	0.552													5	84					0	0	0	0	C	176993782	C	C	176993782	3	2	23	1	0	0	0	0	1	0	0	0	1066	1290	45	2	2753	2	ASTN1	1	176993782	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3838098	176993782	72256839	35	4650											
ASPM	259266	broad.mit.edu	37	chr1	197072981	197072981	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagtagctgcttttttgacTtgcaagaagttcttcctctg	8	16	8	9	0	2	2	0	1	2	1	3	2	3	2	1	0	3	5	1	0	4	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:197072981T>A	uc001gtu.2	-	18	5657	c.5400A>T	c.(5398-5400)CAA>CAT	p.Q1800H	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1800					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CTTTTTTGACTTGCAAGAAGT	0.368													93	146					0	0	0	0	A	197072981	A	A	197072981	3	1	23	1	0	0	0	0	1	0	0	0	1058	1606	56	5	5077	5	ASPM	1	197072981	Missense_Mutation	SNP	T	TCGA-BB-4223-01A-01D-1434-08	20079199	197072981	52177640	36	4651											
PPP1R15B	84919	broad.mit.edu	37	chr1	204379825	204379825	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctatttccatcactgttctGatagctgacttctagcctag	8	15	7	11	0	3	2	1	2	2	0	4	2	4	2	2	0	2	3	2	0	4	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:204379825G>C	uc001hav.3	-	1	1120	c.715C>G	c.(715-717)CAG>GAG	p.Q239E		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	239					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			TCACTGTTCTGATAGCTGACT	0.507													6	210					0	0	0	0	C	204379825	C	C	204379825	3	2	23	1	0	0	0	0	1	0	0	0	12424	1299	45	2	1434	2	PPP1R15B	1	204379825	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	7306844	204379825	44870796	37	4652											
MAPKAPK2	9261	broad.mit.edu	37	chr1	206856279	206856279	+	5'Flank	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagatgttacatgtcttgctCaaggtaacccagttggagga	11	11	12	7	0	2	1	1	0	1	1	2	4	2	3	1	3	3	4	1	3	3	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:206856279C>G	uc001hem.1	+						DYRK3_uc001hek.2_RNA|MAPKAPK2_uc001hel.1_5'Flank	NM_032960	NP_116584	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated						activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			atgtcttgctcaaggtaaccc	0.035													8	188					0	0	0	0	G	206856279	G	G	206856279	1	3	23	0	1	0	0	0	0	0	0	0	9342	841	29	2		2	MAPKAPK2	1	206856279	5'Flank	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2476454	206856279	42394342	38	4653											
NEK2	4751	broad.mit.edu	37	chr1	211842543	211842543	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctcactcaatacagggctGgaatcctgcgatttttctgg	9	12	10	10	1	3	0	2	0	1	0	4	2	4	1	1	3	3	2	1	3	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:211842543G>A	uc001hir.1	-	6	1043	c.897C>T	c.(895-897)TCC>TCT	p.S299S	NEK2_uc001hiq.1_Silent_p.S299S|NEK2_uc001his.3_Silent_p.S299S|NEK2_uc001hit.1_RNA	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	299	Interaction with PCNT.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		ATACAGGGCTGGAATCCTGCG	0.443													16	424					0	0	0	0	A	211842543	A	A	211842543	2	1	23	1	0	0	0	0	0	0	0	1	10378	1335	47	4		4	NEK2	1	211842543	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4986264	211842543	37408078	39	4654											
PROX1	5629	broad.mit.edu	37	chr1	214171409	214171409	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctggaaaagacagagccTctcctgaatccttagactta	12	11	7	11	0	2	4	0	1	2	3	5	5	3	5	3	1	1	0	3	1	5	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:214171409T>C	uc001hkh.2	+	2	1803	c.1531T>C	c.(1531-1533)TCT>CCT	p.S511P	PROX1_uc001hkg.1_Missense_Mutation_p.S511P	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	511					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		AGACAGAGCCTCTCCTGAATC	0.562													5	211					0	0	0	0	C	214171409	C	C	214171409	3	2	23	1	0	0	0	0	1	0	0	0	12622	1551	54	5	1533	5	PROX1	1	214171409	Missense_Mutation	SNP	T	TCGA-BB-4223-01A-01D-1434-08	2328866	214171409	35079212	40	4655											
TP53BP2	7159	broad.mit.edu	37	chr1	223984046	223984046	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagaggccttggtgcgttaGacagtttctttcgtaaggct	7	15	12	7	2	1	2	0	0	1	2	2	2	1	2	1	3	1	4	1	3	3	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:223984046G>C	uc010pvb.1	-	13	2487	c.2195C>G	c.(2194-2196)TCT>TGT	p.S732C	TP53BP2_uc001hod.2_Missense_Mutation_p.S603C|TP53BP2_uc010puz.1_5'UTR|TP53BP2_uc010pva.1_Missense_Mutation_p.S371C	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	726					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		TGGTGCGTTAGACAGTTTCTT	0.438													6	261					0	0	0	0	C	223984046	C	C	223984046	3	2	23	1	0	0	0	0	1	0	0	0	16451	942	33	2	1233	2	TP53BP2	1	223984046	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	9812637	223984046	25266575	41	4656											
OBSCN	84033	broad.mit.edu	37	chr1	228480247	228480247	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctgccaggttcatagaaGatgtgaaaaaccaggaggcc	13	7	12	9	0	1	3	1	1	0	2	1	4	1	4	4	3	3	1	4	3	4	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:228480247G>T	uc009xez.1	+	40	10671	c.10627G>T	c.(10627-10629)GAT>TAT	p.D3543Y	OBSCN_uc001hsn.2_Missense_Mutation_p.D3543Y|OBSCN_uc001hsq.1_Missense_Mutation_p.D799Y	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3543	Ig-like 36.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GTTCATAGAAGATGTGAAAAA	0.567													9	152					1.33987e-11	1.39401e-11	1	0	T	228480247	T	T	228480247	3	4	23	1	0	0	0	0	1	0	0	0	10866	942	33	2	10781	2	OBSCN	1	228480247	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4496201	228480247	20770374	42	4657											
C1orf96	126731	broad.mit.edu	37	chr1	229462743	229462743	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttatcttctacatctttCactggcagtgcttttgaaaa	9	17	7	8	0	4	1	1	1	3	0	4	1	4	1	0	2	2	3	0	2	4	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:229462743C>A	uc001htl.3	-	3	456	c.378G>T	c.(376-378)GTG>GTT	p.V126V	C1orf96_uc009xfc.2_RNA	NM_145257	NP_660300	Q6IQ19	CA096_HUMAN	hypothetical protein LOC126731	126						centrosome					0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.178)				CTACATCTTTCACTGGCAGTG	0.328													52	118					6.08268e-21	6.37675e-21	1	0	A	229462743	A	A	229462743	2	1	23	1	0	0	0	0	0	0	0	1	2083	813	29	2		2	C1orf96	1	229462743	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	982496	229462743	19787878	43	4658											
LYST	1130	broad.mit.edu	37	chr1	235972988	235972988	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgcagtgttttcttttgtCttggtgcaaaagggtcaggc	6	15	12	8	0	3	0	1	0	2	0	3	0	3	0	1	3	2	3	1	3	2	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:235972988C>G	uc001hxj.2	-	5	1305	c.1130G>C	c.(1129-1131)AGA>ACA	p.R377T	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.R377T	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	377					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTTCTTTTGTCTTGGTGCAAA	0.378									Chediak-Higashi_syndrome				10	281					0	0	0	0	G	235972988	G	G	235972988	3	3	23	1	0	0	0	0	1	0	0	0	9179	913	32	2	10471	2	LYST	1	235972988	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	6510245	235972988	13277633	44	4659											
OR2T4	127074	broad.mit.edu	37	chr1	248525533	248525533	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgaagttcctgctgtattGaatctctcctgctcagacac	8	14	8	11	0	2	3	1	2	1	1	5	3	4	3	2	0	2	4	2	0	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr1:248525533G>A	uc001ieh.1	+	1	651	c.651G>A	c.(649-651)TTG>TTA	p.L217L		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	217	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGCTGTATTGAATCTCTCCT	0.478													13	282					0	0	0	0	A	248525533	A	A	248525533	2	1	23	1	0	0	0	0	0	0	0	1	11081	1281	45	2		2	OR2T4	1	248525533	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	12552545	248525533	725088	45	4660											
TPO	7173	broad.mit.edu	37	chr2	1497617	1497617	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcggcctgcctcgcctggaGacccccgctgacctgagcac	5	6	12	18	3	0	3	0	2	0	1	1	4	0	3	6	2	3	2	6	2	0	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:1497617G>A	uc002qww.2	+	11	1903	c.1812G>A	c.(1810-1812)GAG>GAA	p.E604E	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Silent_p.E547E|TPO_uc002qwr.2_Silent_p.E604E|TPO_uc002qwx.2_Silent_p.E547E|TPO_uc010yio.1_Silent_p.E431E|TPO_uc010yip.1_Silent_p.E604E|TPO_uc002qwy.1_5'UTR|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	604	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CTCGCCTGGAGACCCCCGCTG	0.587													28	35					0	0	0	0	A	1497617	A	A	1497617	2	1	23	1	0	0	0	0	0	0	0	1	16477	933	33	2		2	TPO	2	1497617	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08		1497617	241701756	46	4661											
ODC1	4953	broad.mit.edu	37	chr2	10582007	10582007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aattaaatgatccatagacgCcatcattcacataatacata	18	11	3	9	1	2	2	2	1	0	1	3	2	3	2	2	0	1	0	2	0	7	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:10582007C>T	uc010exg.1	-	10	1396	c.962G>A	c.(961-963)GGC>GAC	p.G321D	ODC1_uc002ran.1_Missense_Mutation_p.G7D|ODC1_uc002rao.1_Missense_Mutation_p.G321D|ODC1_uc010yjd.1_Missense_Mutation_p.G191D	NM_002539	NP_002530	P11926	DCOR_HUMAN	ornithine decarboxylase 1	321					polyamine biosynthetic process|regulation of cellular amino acid metabolic process|response to virus	cytosol	ornithine decarboxylase activity|protein binding			ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.161)	Pyridoxal Phosphate(DB00114)|Spermine(DB00127)	TCCATAGACGCCATCATTCAC	0.373													92	149					0	0	0	0	T	10582007	T	T	10582007	3	4	23	1	0	0	0	0	1	0	0	0	10879	739	26	4	435	4	ODC1	2	10582007	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	9084390	10582007	232617366	47	4662											
LAPTM4A	9741	broad.mit.edu	37	chr2	20240727	20240727	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctggcatggagtttggatGagtcacttccacagtcagca	10	10	12	9	0	2	1	2	1	0	0	3	3	3	3	1	3	2	4	1	3	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:20240727G>A	uc002rdm.2	-	2	665	c.157C>T	c.(157-159)CAT>TAT	p.H53Y	LAPTM4A_uc002rdn.2_Missense_Mutation_p.H11Y|LAPTM4A_uc010yjx.1_Missense_Mutation_p.H53Y	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	53					transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGTTTGGATGAGTCACTTCC	0.368													9	157					0	0	0	0	A	20240727	A	A	20240727	3	1	23	1	0	0	0	0	1	0	0	0	8664	1290	45	2	568	2	LAPTM4A	2	20240727	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	9658720	20240727	222958646	48	4663											
ATAD2B	54454	broad.mit.edu	37	chr2	24033258	24033258	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatctagtctatgcacagaGaatctttctagagtgtgcaa	13	12	9	7	0	4	3	0	0	4	3	4	4	4	3	0	0	2	2	0	0	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:24033258G>C	uc002rek.3	-	18	2676	c.2382C>G	c.(2380-2382)TTC>TTG	p.F794L	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Missense_Mutation_p.F39L|ATAD2B_uc002rej.3_5'UTR	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	794							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATGCACAGAGAATCTTTCTA	0.478													5	102					0	0	0	0	C	24033258	C	C	24033258	3	2	23	1	0	0	0	0	1	0	0	0	1074	933	33	2	2038	2	ATAD2B	2	24033258	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3792531	24033258	219166115	49	4664											
NCOA1	8648	broad.mit.edu	37	chr2	24928094	24928094	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatcatgggaattcatatCatcgacaggtactacttatt	12	15	6	8	1	4	0	4	0	0	0	5	2	4	1	0	2	2	1	0	2	5	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:24928094C>T	uc002rfk.2	+	10	1347	c.1089C>T	c.(1087-1089)ATC>ATT	p.I363I	NCOA1_uc010eye.2_Silent_p.I363I|NCOA1_uc002rfi.2_Silent_p.I212I|NCOA1_uc002rfj.2_Silent_p.I363I|NCOA1_uc002rfl.2_Silent_p.I363I	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	363	Interaction with STAT3.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAATTCATATCATCGACAGGT	0.378			T	PAX3	alveolar rhadomyosarcoma								5	129					0	0	0	0	T	24928094	T	T	24928094	2	4	23	1	0	0	0	0	0	0	0	1	10282	816	29	2		2	NCOA1	2	24928094	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	894836	24928094	218271279	50	4665											
PLB1	151056	broad.mit.edu	37	chr2	28789673	28789673	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacgttacagcgtcggcggaGatgagaacatcggcaccgtt	10	7	13	11	6	0	2	0	1	0	2	2	4	0	2	1	3	3	3	1	3	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:28789673G>A	uc002rmb.1	+	20	1291	c.1291G>A	c.(1291-1293)GAT>AAT	p.D431N	PLB1_uc010ezj.1_Missense_Mutation_p.D442N|PLB1_uc002rmc.2_Missense_Mutation_p.D119N|PLB1_uc002rmd.1_5'UTR	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	431	4 X 308-326 AA approximate repeats.|2.|Extracellular (Potential).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CGTCGGCGGAGATGAGAACAT	0.622											OREG0014523	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	109					0	0	0	0	A	28789673	A	A	28789673	3	1	23	1	0	0	0	0	1	0	0	0	12079	942	33	2	1402	2	PLB1	2	28789673	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3861579	28789673	214409700	51	4666											
PRKD3	23683	broad.mit.edu	37	chr2	37520348	37520348	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcagctgcaaaatgttttCtgagttcatgtcatggcgaa	12	13	9	7	1	4	1	3	1	1	0	4	2	4	1	0	1	2	4	0	1	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:37520348C>T	uc002rqd.2	-	2	910	c.355G>A	c.(355-357)GAA>AAA	p.E119K	PRKD3_uc002rqf.1_Missense_Mutation_p.E119K	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	119					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				AAAATGTTTTCTGAGTTCATG	0.398													79	106					0	0	0	0	T	37520348	T	T	37520348	3	4	23	1	0	0	0	0	1	0	0	0	12582	922	32	2	2385	2	PRKD3	2	37520348	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	8730675	37520348	205679025	52	4667											
SOS1	6654	broad.mit.edu	37	chr2	39234270	39234270	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caactcttgaaagacttgtaGaatctcaataattcgactca	15	12	5	9	1	3	3	2	1	2	2	5	4	3	3	0	0	1	1	0	0	6	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:39234270G>C	uc002rrk.3	-	16	2616	c.2575C>G	c.(2575-2577)CTA>GTA	p.L859V	SOS1_uc002rrj.3_Missense_Mutation_p.L473V	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	859	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				AAGACTTGTAGAATCTCAATA	0.348									Noonan_syndrome				6	269					0	0	0	0	C	39234270	C	C	39234270	3	2	23	1	0	0	0	0	1	0	0	0	15000	933	33	2	1458	2	SOS1	2	39234270	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1713922	39234270	203965103	53	4668											
C2orf61	285051	broad.mit.edu	37	chr2	47378441	47378441	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggcttggccgtggtttgtCtttgaatgagtaagtagcca	7	13	15	6	1	1	2	0	2	1	0	1	2	1	2	2	4	1	4	2	4	3	5	rs147631903		TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:47378441C>G	uc002rvs.2	-	3	482	c.355G>C	c.(355-357)GAC>CAC	p.D119H	C2orf61_uc010fbd.2_RNA|C2orf61_uc010yog.1_Missense_Mutation_p.D119H	NM_173649	NP_775920	Q8N801	CB061_HUMAN	hypothetical protein LOC285051 isoform 2	119								p.0?(2)			0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CGTGGTTTGTCTTTGAATGAG	0.473													10	173					0	0	0	0	G	47378441	G	G	47378441	3	3	23	1	0	0	0	0	1	0	0	0	2190	913	32	2	426	2	C2orf61	2	47378441	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	8144171	47378441	195820932	54	4669											
CCDC85A	114800	broad.mit.edu	37	chr2	56599513	56599513	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaggcaacctccaactagaaAcagctcaaatatggagaaag	19	5	8	9	0	1	2	1	0	0	2	2	3	2	2	2	2	4	2	2	2	8	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:56599513A>G	uc002rzn.2	+	4	1854	c.1352A>G	c.(1351-1353)AAC>AGC	p.N451S		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	451										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CCAACTAGAAACAGCTCAAAT	0.502													7	10					0	0	0	0	G	56599513	G	G	56599513	3	3	23	1	0	0	0	0	1	0	0	0	2872	43	2	5	1366	5	CCDC85A	2	56599513	Missense_Mutation	SNP	A	TCGA-BB-4223-01A-01D-1434-08	9221072	56599513	186599860	55	4670											
EHBP1	23301	broad.mit.edu	37	chr2	63053232	63053232	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatcttccaggaatccccttCtggtcgaaggaaagctcttg	10	11	9	11	1	3	0	0	0	3	0	6	3	5	2	3	3	1	1	3	3	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:63053232C>G	uc002sby.2	+	6	805	c.323C>G	c.(322-324)TCT>TGT	p.S108C	EHBP1_uc010fcp.2_Missense_Mutation_p.S108C|EHBP1_uc010fcq.1_Missense_Mutation_p.S108C|EHBP1_uc002sbx.2_Missense_Mutation_p.S108C|EHBP1_uc002sbz.2_Missense_Mutation_p.S108C|EHBP1_uc002scb.2_Missense_Mutation_p.S108C	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	108						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			GAATCCCCTTCTGGTCGAAGG	0.318									Hereditary_Prostate_Cancer				3	107					0	0	0	0	G	63053232	G	G	63053232	3	3	23	1	0	0	0	0	1	0	0	0	4997	913	32	2	341	2	EHBP1	2	63053232	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	6453719	63053232	180146141	56	4671											
NAT8	9027	broad.mit.edu	37	chr2	73868552	73868552	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagggcagggaagaggctGatgctgaacacgagggctag	12	4	17	8	1	0	3	0	2	0	1	0	5	0	4	0	4	2	4	0	4	3	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:73868552G>A	uc002sji.1	-	2	371	c.204C>T	c.(202-204)ATC>ATT	p.I68I		NM_003960	NP_003951	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8	68	Helical; (Potential).|N-acetyltransferase.				gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			ovary(1)	1						GGAAGAGGCTGATGCTGAACA	0.537													10	224					0	0	0	0	A	73868552	A	A	73868552	2	1	23	1	0	0	0	0	0	0	0	1	10232	1280	45	2		2	NAT8	2	73868552	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	10815320	73868552	169330821	57	4672											
MRPS9	64965	broad.mit.edu	37	chr2	105665724	105665724	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggattttattaaaaagcaGattgaagagttcaacatagg	17	11	10	3	0	1	3	1	1	0	2	1	5	1	4	0	2	2	2	0	2	7	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:105665724G>A	uc002tcn.3	+	2	299	c.231G>A	c.(229-231)CAG>CAA	p.Q77Q		NM_182640	NP_872578	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9 precursor	77					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						TTAAAAAGCAGATTGAAGAGT	0.348													7	99					0	0	0	0	A	105665724	A	A	105665724	2	1	23	1	0	0	0	0	0	0	0	1	9902	933	33	2		2	MRPS9	2	105665724	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	31797172	105665724	137533649	58	4673											
SLC20A1	6574	broad.mit.edu	37	chr2	113410356	113410356	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaataaacctcttttccatCatgtatactggagcaccgtg	11	12	8	10	1	2	0	1	0	1	0	3	2	3	2	3	2	3	2	3	2	5	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:113410356C>T	uc002tib.2	+	5	1085	c.639C>T	c.(637-639)ATC>ATT	p.I213I		NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	213	Helical; (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						TCTTTTCCATCATGTATACTG	0.353													7	273					0	0	0	0	T	113410356	T	T	113410356	2	4	23	1	0	0	0	0	0	0	0	1	14503	816	29	2		2	SLC20A1	2	113410356	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	7744632	113410356	129789017	59	4674											
PROC	5624	broad.mit.edu	37	chr2	128186312	128186312	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgtgtgcgggcatcctcggGgaccggcaggatgcctgcga	5	7	17	12	4	0	0	0	0	0	0	2	3	1	2	3	5	3	2	3	5	0	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:128186312G>A	uc002tok.2	+	9	1249	c.1176G>A	c.(1174-1176)GGG>GGA	p.G392G	PROC_uc002tol.2_Silent_p.G413G|PROC_uc010yzi.1_Silent_p.G448G|PROC_uc010yzj.1_Silent_p.G287G|PROC_uc010yzk.1_Silent_p.G447G|PROC_uc002tom.2_Silent_p.G426G	NM_000312	NP_000303	P04070	PROC_HUMAN	protein C	392	Peptidase S1.		G -> R (in ADPROCD; Osaka-9).		blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	GCATCCTCGGGGACCGGCAGG	0.632													8	205					0	0	0	0	A	128186312	A	A	128186312	2	1	23	1	0	0	0	0	0	0	0	1	12607	1219	43	4		4	PROC	2	128186312	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	14775956	128186312	115013061	60	4675											
POTEF	728378	broad.mit.edu	37	chr2	130832366	130832366	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctatagccatgctcggtGaggatcttcatgaggtagtc	10	11	11	9	1	2	2	1	2	1	0	4	3	2	3	2	3	3	2	2	3	4	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:130832366G>A	uc010fmh.2	-	17	3079	c.2679C>T	c.(2677-2679)CTC>CTT	p.L893L		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	893	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						CATGCTCGGTGAGGATCTTCA	0.587													9	98					0	0	0	0	A	130832366	A	A	130832366	2	1	23	1	0	0	0	0	0	0	0	1	12320	1277	45	2		2	POTEF	2	130832366	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2646054	130832366	112367007	61	4676											
ACMSD	130013	broad.mit.edu	37	chr2	135659429	135659429	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagagaaaacaatttgaatGactgaatttactacaaaggc	18	10	8	5	0	0	5	0	4	0	1	0	6	0	5	0	1	3	0	0	1	8	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:135659429G>C	uc002ttz.2	+	10	1077	c.1010G>C	c.(1009-1011)TGA>TCA	p.*337S	ACMSD_uc002tua.2_Nonstop_Mutation_p.*279S|uc010zbe.1_Intron	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	337					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		CAATTTGAATGACTGAATTTA	0.299													3	75					0	0	0	0	C	135659429	C	C	135659429	4	2	23	1	0	0	0	0	0	0	0	0	144	1285	45	2	1048	2	ACMSD	2	135659429	Nonstop_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4827063	135659429	107539944	62	4677											
UBXN4	23190	broad.mit.edu	37	chr2	136537915	136537915	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtgagagtaacatcgtcaGaacccccaaaccctgcatca	14	6	7	14	1	2	2	2	1	0	2	3	3	2	2	3	0	4	2	3	0	3	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:136537915G>A	uc002tur.2	+	12	1659	c.1348G>A	c.(1348-1350)GAA>AAA	p.E450K	UBXN4_uc002tus.2_Missense_Mutation_p.E216K|UBXN4_uc002tut.2_Missense_Mutation_p.E86K	NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	450	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						AACATCGTCAGAACCCCCAAA	0.388													13	256					0	0	0	0	A	136537915	A	A	136537915	3	1	23	1	0	0	0	0	1	0	0	0	16984	943	33	2	1394	2	UBXN4	2	136537915	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	878486	136537915	106661458	63	4678											
ITGB6	3694	broad.mit.edu	37	chr2	161052754	161052754	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacttaaggatcaagctttGaggcgcaatctgaacaatgt	14	10	9	8	1	2	2	1	2	1	0	2	3	2	3	0	2	3	2	0	2	6	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:161052754G>A	uc002ubh.2	-	3	335	c.319C>T	c.(319-321)CAA>TAA	p.Q107*	ITGB6_uc010fow.1_RNA|ITGB6_uc010fou.2_Nonsense_Mutation_p.Q107*|ITGB6_uc010zcq.1_Nonsense_Mutation_p.Q65*|ITGB6_uc010fov.1_Nonsense_Mutation_p.Q107*	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	107	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						ATCAAGCTTTGAGGCGCAATC	0.383													13	244					0	0	0	0	A	161052754	A	A	161052754	4	1	23	1	0	0	0	0	0	1	0	0	7938	1299	45	2	2099	2	ITGB6	2	161052754	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	24514839	161052754	82146619	64	4679											
HOXD10	3236	broad.mit.edu	37	chr2	176983913	176983913	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaaactcaagaagatgagccGagagaaccggatccgagaac	17	3	12	9	3	1	5	1	1	0	4	2	10	2	6	3	1	4	0	3	1	5	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:176983913G>C	uc002ukj.2	+	2	1047	c.977G>C	c.(976-978)CGA>CCA	p.R326P		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	326						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		AAGATGAGCCGAGAGAACCGG	0.453													5	101					0	0	0	0	C	176983913	C	C	176983913	3	2	23	1	0	0	0	0	1	0	0	0	7358	1058	37	3	983	3	HOXD10	2	176983913	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	15931159	176983913	66215460	65	4680											
TTN	7273	broad.mit.edu	37	chr2	179569097	179569097	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcaagtctggccttctttCagagtcacatcctgaagatg	9	12	10	10	0	4	3	2	1	2	2	5	3	5	3	2	1	1	1	2	1	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:179569097C>G	uc010zfg.1	-	103	26492	c.26268G>C	c.(26266-26268)CTG>CTC	p.L8756L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.L5417L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9683							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCCTTCTTTCAGAGTCACAT	0.428													16	338					0	0	0	0	G	179569097	G	G	179569097	2	3	23	1	0	0	0	0	0	0	0	1	16803	813	29	2		2	TTN	2	179569097	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2585184	179569097	63630276	66	4681											
DNAH7	56171	broad.mit.edu	37	chr2	196801458	196801458	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagctccaaaagttcattaGattttttcagcctttccagc	10	15	6	10	0	2	2	2	1	0	1	4	2	4	2	3	0	3	2	3	0	3	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:196801458G>T	uc002utj.3	-	20	3238	c.3137C>A	c.(3136-3138)TCT>TAT	p.S1046Y		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1046	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AAGTTCATTAGATTTTTTCAG	0.299													4	103					0.00909568	0.0092301	1	0	T	196801458	T	T	196801458	3	4	23	1	0	0	0	0	1	0	0	0	4628	942	33	2	9121	2	DNAH7	2	196801458	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	17232361	196801458	46397915	67	4682											
SGOL2	151246	broad.mit.edu	37	chr2	201437872	201437872	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataaagatgcacatgtccaaGaaagctatacaaaagatctt	19	9	6	7	0	1	3	0	0	1	3	2	3	2	3	1	0	3	2	1	0	8	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:201437872G>C	uc002uvw.2	+	7	2916	c.2803G>C	c.(2803-2805)GAA>CAA	p.E935Q	SGOL2_uc010zhd.1_Missense_Mutation_p.E935Q|SGOL2_uc010zhe.1_Missense_Mutation_p.E935Q	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	935					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						ACATGTCCAAGAAAGCTATAC	0.274													9	198					0	0	0	0	C	201437872	C	C	201437872	3	2	23	1	0	0	0	0	1	0	0	0	14282	943	33	2	2825	2	SGOL2	2	201437872	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4636414	201437872	41761501	68	4683											
ALS2	57679	broad.mit.edu	37	chr2	202572650	202572650	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agtgcaaaaagacttcctttCggttggcagaggagcagaga	13	8	13	7	1	0	3	0	0	0	3	2	5	1	4	1	3	2	4	1	3	2	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:202572650C>G	uc002uyo.2	-	28	4701	c.4345G>C	c.(4345-4347)GAA>CAA	p.E1449Q	ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	1449					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						GACTTCCTTTCGGTTGGCAGA	0.438													3	103					0	0	0	0	G	202572650	G	G	202572650	3	3	23	1	0	0	0	0	1	0	0	0	550	893	31	3	656	3	ALS2	2	202572650	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1134778	202572650	40626723	69	4684											
RPL37A	6168	broad.mit.edu	37	chr2	217364725	217364725	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactgtggttcctgcatgaaGacagtggctggcggtgcctg	6	10	15	10	1	0	2	0	1	0	1	1	2	1	2	2	4	2	3	2	4	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:217364725G>C	uc002vgf.2	+	3	264	c.186G>C	c.(184-186)AAG>AAC	p.K62N	RPL37A_uc002vgg.2_Missense_Mutation_p.K62N	NM_000998	NP_000989	P61513	RL37A_HUMAN	ribosomal protein L37a	62					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	metal ion binding|protein binding|structural constituent of ribosome			ovary(1)	1		Renal(323;0.0458)		Epithelial(149;3.51e-06)|all cancers(144;0.000249)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTGCATGAAGACAGTGGCTG	0.473													4	132					0	0	0	0	C	217364725	C	C	217364725	3	2	23	1	0	0	0	0	1	0	0	0	13655	933	33	2	196	2	RPL37A	2	217364725	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	14792075	217364725	25834648	70	4685											
PLCD4	84812	broad.mit.edu	37	chr2	219496958	219496958	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacctgagttggaagagtcaGaattggcgctggagtcccag	11	8	14	8	1	1	3	1	1	0	2	2	5	2	5	2	3	1	2	2	3	3	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:219496958G>C	uc002vij.1	+	10	1567	c.1372G>C	c.(1372-1374)GAA>CAA	p.E458Q	PLCD4_uc010zkk.1_Intron	NM_032726	NP_116115	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	458	Glu-rich.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)	3		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GGAAGAGTCAGAATTGGCGCT	0.502													4	17					0	0	0	0	C	219496958	C	C	219496958	3	2	23	1	0	0	0	0	1	0	0	0	12088	943	33	2	1406	2	PLCD4	2	219496958	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2132233	219496958	23702415	71	4686											
COL4A4	1286	broad.mit.edu	37	chr2	227973311	227973311	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttaccgggtctcccatttGcccctttactcccacaccgg	5	12	6	18	2	2	0	0	0	2	0	4	0	3	0	6	2	3	0	6	2	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:227973311G>A	uc010zlt.1	-	12	1375	c.721C>T	c.(721-723)CAA>TAA	p.Q241*		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	241	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCTCCCATTTGCCCCTTTACT	0.418													7	231					0	0	0	0	A	227973311	A	A	227973311	4	1	23	1	0	0	0	0	0	1	0	0	3708	1328	46	4	4499	4	COL4A4	2	227973311	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	8476353	227973311	15226062	72	4687											
NMUR1	10316	broad.mit.edu	37	chr2	232393432	232393432	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtccgacacggccaggctGaagaggtagtagttggtagg	10	7	17	7	2	0	2	0	1	0	1	1	3	1	2	2	6	0	5	2	6	4	4	rs139992213	by1000genomes	TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr2:232393432G>A	uc002vry.3	-	2	410	c.300C>T	c.(298-300)TTC>TTT	p.F100F		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	100	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CGGCCAGGCTGAAGAGGTAGT	0.627													10	156					0	0	0	0	A	232393432	A	A	232393432	2	1	23	1	0	0	0	0	0	0	0	1	10560	1281	45	2		2	NMUR1	2	232393432	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4420121	232393432	10805941	73	4688											
EDEM1	9695	broad.mit.edu	37	chr3	5243458	5243458	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcctgggaagcctcctttCtgctcacagaataataactg	10	11	9	11	0	2	1	1	0	1	1	4	2	4	2	3	2	3	1	3	2	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:5243458C>T	uc003bqi.2	+	4	839	c.707C>T	c.(706-708)TCT>TTT	p.S236F	EDEM1_uc011asz.1_Missense_Mutation_p.S14F|EDEM1_uc003bqh.2_Missense_Mutation_p.S236F	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	236	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		AGCCTCCTTTCTGCTCACAGA	0.408													85	144					0	0	0	0	T	5243458	T	T	5243458	3	4	23	1	0	0	0	0	1	0	0	0	4933	913	32	2	721	2	EDEM1	3	5243458	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08		5243458	192778972	74	4689											
RAF1	5894	broad.mit.edu	37	chr3	12660106	12660106	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcatctgatgcccggcgctGatagccaaactgctgaacta	11	9	9	12	2	2	3	1	3	1	0	2	3	2	3	2	1	5	2	2	1	4	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:12660106G>C	uc003bxf.3	-	2	530	c.115C>G	c.(115-117)CAG>GAG	p.Q39E	RAF1_uc011auu.1_Translation_Start_Site	NM_002880	NP_002871	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog	39					activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)	GCCCGGCGCTGATAGCCAAAC	0.473			T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				13	201					0	0	0	0	C	12660106	C	C	12660106	3	2	23	1	0	0	0	0	1	0	0	0	13067	1299	45	2	1895	2	RAF1	3	12660106	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	7416648	12660106	185362324	75	4690											
EPM2AIP1	9852	broad.mit.edu	37	chr3	37033799	37033799	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatgtatgagacgagtcctGagttctcaccaatcatcctc	10	12	7	12	1	3	2	3	2	1	1	7	4	5	2	3	0	0	2	3	0	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:37033799G>A	uc003cgk.2	-	1	997	c.770C>T	c.(769-771)TCA>TTA	p.S257L	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	257						endoplasmic reticulum					0						GACGAGTCCTGAGTTCTCACC	0.473													13	302					0	0	0	0	A	37033799	A	A	37033799	3	1	23	1	0	0	0	0	1	0	0	0	5208	1294	45	2	1057	2	EPM2AIP1	3	37033799	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	24373693	37033799	160988631	76	4691											
DLEC1	9940	broad.mit.edu	37	chr3	38101288	38101288	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctacggaaacatcatttGatctccccagaagattacta	13	12	6	10	1	2	3	1	1	1	2	3	4	2	4	2	1	4	1	2	1	5	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:38101288G>A	uc003cho.1	+	3	639	c.618G>A	c.(616-618)TTG>TTA	p.L206L	DLEC1_uc003chp.1_Silent_p.L206L|DLEC1_uc010hgv.1_Silent_p.L206L|DLEC1_uc010hgw.1_5'Flank|DLEC1_uc003chq.1_5'Flank	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	206					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		AACATCATTTGATCTCCCCAG	0.478													21	444					0	0	0	0	A	38101288	A	A	38101288	2	1	23	1	0	0	0	0	0	0	0	1	4574	1281	45	2		2	DLEC1	3	38101288	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1067489	38101288	159921142	77	4692											
ZNF197	10168	broad.mit.edu	37	chr3	44684611	44684611	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagtttttattctgaagaaGagcctcattttacatcaaag	15	14	6	6	0	3	3	2	1	1	2	3	3	3	3	1	0	2	1	1	0	6	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:44684611G>C	uc003cnm.2	+	6	2195	c.1989G>C	c.(1987-1989)AAG>AAC	p.K663N	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	663	C2H2-type 11.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		TTCTGAAGAAGAGCCTCATTT	0.403													3	95					0	0	0	0	C	44684611	C	C	44684611	3	2	23	1	0	0	0	0	1	0	0	0	17826	933	33	2	2007	2	ZNF197	3	44684611	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	6583323	44684611	153337819	78	4693											
MAP4	4134	broad.mit.edu	37	chr3	47894525	47894525	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaccagaatgtcatcattaGatgcctggaaaataaaaggt	17	9	9	6	0	2	3	2	0	0	3	2	4	2	4	2	2	1	0	2	2	6	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:47894525G>C	uc003csb.2	-	19	3982	c.3456C>G	c.(3454-3456)ATC>ATG	p.I1152M	MAP4_uc003csc.3_Intron|MAP4_uc003crw.2_Missense_Mutation_p.I231M|MAP4_uc003crx.2_Missense_Mutation_p.I328M|MAP4_uc011bbe.1_Intron|MAP4_uc003cry.2_Missense_Mutation_p.I887M|MAP4_uc003csa.3_Intron|MAP4_uc003crz.3_RNA	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	1152					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GTCATCATTAGATGCCTGGAA	0.502													6	148					0	0	0	0	C	47894525	C	C	47894525	3	2	23	1	0	0	0	0	1	0	0	0	9311	932	33	2	157	2	MAP4	3	47894525	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3209914	47894525	150127905	79	4694											
COL7A1	1294	broad.mit.edu	37	chr3	48624640	48624640	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctggcgtctgtgtgacaGatgcctcaggaccccgcaca	8	8	11	14	2	2	2	1	1	1	1	2	3	2	3	4	2	2	1	4	2	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:48624640G>A	uc003ctz.2	-	23	3123	c.3122C>T	c.(3121-3123)TCT>TTT	p.S1041F		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1041	Nonhelical region (NC1).|Fibronectin type-III 9.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGTGTGACAGATGCCTCAGG	0.597													3	69					0	0	0	0	A	48624640	A	A	48624640	3	1	23	1	0	0	0	0	1	0	0	0	3719	942	33	2	6096	2	COL7A1	3	48624640	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	730115	48624640	149397790	80	4695											
COL7A1	1294	broad.mit.edu	37	chr3	48626388	48626388	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaacgtcgctggaagcattGaggatctgcagcctcgacac	11	7	12	11	3	1	2	0	1	1	1	3	5	1	4	1	2	4	3	1	2	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:48626388G>A	uc003ctz.2	-	18	2356	c.2355C>T	c.(2353-2355)CTC>CTT	p.L785L		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	785	Nonhelical region (NC1).|Fibronectin type-III 7.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGAAGCATTGAGGATCTGCA	0.607													8	167					0	0	0	0	A	48626388	A	A	48626388	2	1	23	1	0	0	0	0	0	0	0	1	3719	1277	45	2		2	COL7A1	3	48626388	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1748	48626388	149396042	81	4696											
USP19	10869	broad.mit.edu	37	chr3	49155175	49155175	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctactcccacacgaagcttGacaatcacctcttctgcact	10	10	4	17	1	3	1	1	1	2	0	4	2	4	1	3	0	3	2	3	0	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:49155175G>C	uc003cwd.1	-	4	548	c.387C>G	c.(385-387)GTC>GTG	p.V129V	USP19_uc003cwa.2_5'UTR|USP19_uc003cvz.3_Silent_p.V129V|USP19_uc011bcg.1_Silent_p.V129V|USP19_uc003cwb.2_Silent_p.V114V|USP19_uc003cwc.1_5'Flank|USP19_uc011bch.1_Silent_p.V129V|USP19_uc011bci.1_Silent_p.V114V	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	129	Cytoplasmic (Potential).|CS 1.				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CACGAAGCTTGACAATCACCT	0.433													6	117					0	0	0	0	C	49155175	C	C	49155175	2	2	23	1	0	0	0	0	0	0	0	1	17118	1277	45	2		2	USP19	3	49155175	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	528787	49155175	148867255	82	4697											
PCBP4	57060	broad.mit.edu	37	chr3	51993286	51993286	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaggggaccgcatggcttGagagctgctggagcttggtg	8	8	17	8	1	0	1	0	1	0	1	0	4	0	3	1	5	3	5	1	5	1	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:51993286G>C	uc003dcd.1	-	9	1055	c.659C>G	c.(658-660)TCA>TGA	p.S220*	PCBP4_uc003dcb.1_Nonsense_Mutation_p.S186*|PCBP4_uc003dcc.1_Nonsense_Mutation_p.S241*|PCBP4_uc003dce.1_Silent_p.L221L|PCBP4_uc003dcf.1_Nonsense_Mutation_p.S220*|PCBP4_uc003dcg.1_Nonsense_Mutation_p.S186*|PCBP4_uc003dch.1_Nonsense_Mutation_p.S220*|PCBP4_uc003dci.1_Nonsense_Mutation_p.S60*|PCBP4_uc003dcj.1_Nonsense_Mutation_p.S220*|PCBP4_uc003dck.1_Nonsense_Mutation_p.S177*|PCBP4_uc003dcl.1_Nonsense_Mutation_p.S220*	NM_033010	NP_127503	P57723	PCBP4_HUMAN	poly(rC) binding protein 4 isoform c	220						cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CGCATGGCTTGAGAGCTGCTG	0.632													24	49					0	0	0	0	C	51993286	C	C	51993286	4	2	23	1	0	0	0	0	0	1	0	0	11557	1294	45	2	568	2	PCBP4	3	51993286	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2838111	51993286	146029144	83	4698											
PHF7	51533	broad.mit.edu	37	chr3	52446916	52446916	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaagactgtaaaagaaaaGaaggaatgccagagattgag	20	6	12	3	0	0	6	0	2	0	4	0	8	0	7	1	1	1	1	1	1	7	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:52446916G>C	uc003ddy.2	+	2	827	c.21G>C	c.(19-21)AAG>AAC	p.K7N	BAP1_uc003ddx.2_5'Flank|PHF7_uc003ddz.2_Missense_Mutation_p.K7N	NM_016483	NP_057567	Q9BWX1	PHF7_HUMAN	PHD finger protein 7 isoform 1	7						nucleus	zinc ion binding			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		TAAAAGAAAAGAAGGAATGCC	0.413													3	31					0	0	0	0	C	52446916	C	C	52446916	3	2	23	1	0	0	0	0	1	0	0	0	11894	933	33	2	23	2	PHF7	3	52446916	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	453630	52446916	145575514	84	4699											
C3orf63	23272	broad.mit.edu	37	chr3	56667379	56667379	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtggaatgctgctcatcaGagttggtatctttcaaagga	12	12	11	6	0	4	1	3	0	1	1	4	3	4	3	0	3	2	4	0	3	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:56667379G>C	uc003did.3	-	17	3358	c.3257C>G	c.(3256-3258)TCT>TGT	p.S1086C	C3orf63_uc003dib.3_Missense_Mutation_p.S205C|C3orf63_uc003dic.3_Missense_Mutation_p.S710C|C3orf63_uc003die.3_Missense_Mutation_p.S1147C	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1147										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		CTGCTCATCAGAGTTGGTATC	0.423													20	309					0	0	0	0	C	56667379	C	C	56667379	3	2	23	1	0	0	0	0	1	0	0	0	2249	942	33	2	1660	2	C3orf63	3	56667379	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4220463	56667379	141355051	85	4700											
ADAMTS9	56999	broad.mit.edu	37	chr3	64526833	64526833	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactggaaaacccagcggccGtgtaatccttccgacattgg	11	8	10	12	3	0	0	0	0	0	0	2	2	2	1	4	3	3	1	4	3	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:64526833G>A	uc003dmg.2	-	36	5491	c.5459C>T	c.(5458-5460)ACG>ATG	p.T1820M	ADAMTS9_uc011bfo.1_Missense_Mutation_p.T1792M|ADAMTS9_uc011bfp.1_Missense_Mutation_p.T731M	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1820	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CCCAGCGGCCGTGTAATCCTT	0.468													57	101					0	0	0	0	A	64526833	A	A	64526833	3	1	23	1	0	0	0	0	1	0	0	0	273	1145	40	1	364	1	ADAMTS9	3	64526833	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	7859454	64526833	133495597	86	4701											
OR5H6	79295	broad.mit.edu	37	chr3	97983460	97983460	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtaagatgatatctctctCtgaatgcatggtacaatttt	12	15	8	6	0	2	3	0	2	2	1	4	4	2	3	0	1	2	3	0	1	5	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:97983460C>G	uc003dsi.1	+	1	332	c.332C>G	c.(331-333)TCT>TGT	p.S111C		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	111	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						ATATCTCTCTCTGAATGCATG	0.403													57	150					0	0	0	0	G	97983460	G	G	97983460	3	3	23	1	0	0	0	0	1	0	0	0	11217	913	32	2	334	2	OR5H6	3	97983460	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	33456627	97983460	100038970	87	4702											
KIAA1407	57577	broad.mit.edu	37	chr3	113724691	113724691	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattgccaggtgcactcagaGagacattctgaagggaaccc	12	8	11	10	0	2	3	1	1	1	2	2	5	2	4	2	2	3	1	2	2	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:113724691G>C	uc003eax.2	-	10	1679	c.1532C>G	c.(1531-1533)TCT>TGT	p.S511C	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.S489C|KIAA1407_uc011bip.1_Missense_Mutation_p.S498C	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	511										ovary(2)	2						TGCACTCAGAGAGACATTCTG	0.537													8	458					0	0	0	0	C	113724691	C	C	113724691	3	2	23	1	0	0	0	0	1	0	0	0	8268	942	33	2	1310	2	KIAA1407	3	113724691	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	15741231	113724691	84297739	88	4703											
QTRTD1	79691	broad.mit.edu	37	chr3	113798772	113798772	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctcatatctggtgttagtCggccagatgaggtgctcgag	7	11	15	8	2	2	2	1	1	1	1	4	3	2	2	1	4	1	3	1	4	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:113798772C>T	uc003eay.2	+	8	996	c.766C>T	c.(766-768)CGG>TGG	p.R256W	QTRTD1_uc003eaz.2_Missense_Mutation_p.R268W|QTRTD1_uc011biq.1_Missense_Mutation_p.R133W|QTRTD1_uc011bir.1_Missense_Mutation_p.R150W	NM_024638	NP_078914	Q9H974	QTRD1_HUMAN	queuine tRNA-ribosyltransferase domain	256					queuosine biosynthetic process	mitochondrion	metal ion binding|queuine tRNA-ribosyltransferase activity			central_nervous_system(1)|skin(1)	2						TGGTGTTAGTCGGCCAGATGA	0.428													9	433					0	0	0	0	T	113798772	T	T	113798772	3	4	23	1	0	0	0	0	1	0	0	0	12951	875	31	1	788	1	QTRTD1	3	113798772	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	74081	113798772	84223658	89	4704											
TOPBP1	11073	broad.mit.edu	37	chr3	133347312	133347312	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaagtggctttggggcttCttcctgtccatggaaaataa	9	13	12	7	0	1	1	0	1	1	0	3	2	3	2	2	4	0	2	2	4	4	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:133347312C>G	uc003eps.2	-	16	2830	c.2698G>C	c.(2698-2700)GAA>CAA	p.E900Q	TOPBP1_uc003ept.1_5'UTR	NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	900	BRCT 6.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						TTTGGGGCTTCTTCCTGTCCA	0.373								Other_conserved_DNA_damage_response_genes					4	42					0	0	0	0	G	133347312	G	G	133347312	3	3	23	1	0	0	0	0	1	0	0	0	16436	922	32	2	1922	2	TOPBP1	3	133347312	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	19548540	133347312	64675118	90	4705											
MSL2	55167	broad.mit.edu	37	chr3	135871283	135871283	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaagtaaaggatgaatctGagggtttttctgtctcctca	12	13	9	7	0	4	2	1	2	3	0	5	3	4	3	1	2	0	2	1	2	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:135871283G>A	uc003eqx.1	-	2	1173	c.440C>T	c.(439-441)TCA>TTA	p.S147L	MSL2_uc011bmb.1_Missense_Mutation_p.S73L	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	147					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						GGATGAATCTGAGGGTTTTTC	0.403													6	167					0	0	0	0	A	135871283	A	A	135871283	3	1	23	1	0	0	0	0	1	0	0	0	9931	1294	45	2	1297	2	MSL2	3	135871283	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2523971	135871283	62151147	91	4706											
XRN1	54464	broad.mit.edu	37	chr3	142074246	142074246	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacaaggaatactaaccttCtcttgtatagttggctgaaa	15	12	7	7	0	1	1	0	1	1	0	2	2	1	2	1	2	3	3	1	2	8	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:142074246C>G	uc003eus.2	-	32	3832	c.3765G>C	c.(3763-3765)GAG>GAC	p.E1255D	XRN1_uc010huu.2_Missense_Mutation_p.E721D|XRN1_uc003eut.2_Missense_Mutation_p.E1255D|XRN1_uc003euu.2_Missense_Mutation_p.E1255D	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1255					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						TACTAACCTTCTCTTGTATAG	0.303													4	199					0	0	0	0	G	142074246	G	G	142074246	3	3	23	1	0	0	0	0	1	0	0	0	17527	912	32	2	1399	2	XRN1	3	142074246	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	6202963	142074246	55948184	92	4707											
PLOD2	5352	broad.mit.edu	37	chr3	145803008	145803008	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggatttgtcaaaacaacatCtgcatccacactaaagtaat	16	11	5	9	0	2	0	1	0	1	0	3	1	3	1	1	1	3	2	1	1	6	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:145803008C>T	uc003evs.1	-	11	1686	c.1180G>A	c.(1180-1182)GAT>AAT	p.D394N	PLOD2_uc003evq.1_Missense_Mutation_p.D54N|PLOD2_uc011bnm.1_Missense_Mutation_p.D339N|PLOD2_uc003evr.1_Missense_Mutation_p.D394N	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	394					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	AAAACAACATCTGCATCCACA	0.284													28	95					0	0	0	0	T	145803008	T	T	145803008	3	4	23	1	0	0	0	0	1	0	0	0	12157	913	32	2	1136	2	PLOD2	3	145803008	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	3728762	145803008	52219422	93	4708											
CPA3	1359	broad.mit.edu	37	chr3	148583121	148583121	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcatcctgcctgtgggtttGattgctaccactcttgcaat	6	15	8	12	0	2	1	1	1	1	0	3	1	3	1	3	1	4	3	3	1	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:148583121G>C	uc003ewm.2	+	1	79	c.27G>C	c.(25-27)TTG>TTC	p.L9F		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	9					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTGTGGGTTTGATTGCTACCA	0.463													7	160					0	0	0	0	C	148583121	C	C	148583121	3	2	23	1	0	0	0	0	1	0	0	0	3806	1281	45	2	29	2	CPA3	3	148583121	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2780113	148583121	49439309	94	4709											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			31	79					0	0	0	0	A	178936082	A	A	178936082	3	1	23	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	30352961	178936082	19086348	95	4710											
KCNMB3	27094	broad.mit.edu	37	chr3	178984446	178984446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgacttacctcccctggCgcctccggctgccctgaagt	6	9	10	16	2	0	2	0	2	0	0	2	2	2	2	6	2	2	1	6	2	3	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:178984446C>T	uc003fjp.1	-	1	393	c.53G>A	c.(52-54)CGC>CAC	p.R18H	KCNMB3_uc011bqc.1_Missense_Mutation_p.R18H	NM_171828	NP_741979	Q9NPA1	KCMB3_HUMAN	calcium-activated potassium channel beta 3	Error:Variant_position_missing_in_Q9NPA1_after_alignment					detection of calcium ion|platelet activation|regulation of action potential in neuron	voltage-gated potassium channel complex	calcium-activated potassium channel activity|potassium channel regulator activity				0	all_cancers(143;5.6e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;2.41e-27)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.03)			CCTCCCCTGGCGCCTCCGGCT	0.587													20	99					0	0	0	0	T	178984446	T	T	178984446	3	4	23	1	0	0	0	0	1	0	0	0	8115	768	27	1	1003	1	KCNMB3	3	178984446	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	48364	178984446	19037984	96	4711											
FXR1	8087	broad.mit.edu	37	chr3	180651167	180651167	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcccttacagttgtttttGaaaataagtaagttattttt	12	19	5	5	0	0	1	0	1	0	0	1	1	1	1	1	0	1	4	1	0	6	9			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:180651167G>C	uc003fkq.2	+	2	119	c.97G>C	c.(97-99)GAA>CAA	p.E33Q	FXR1_uc003fkp.2_5'UTR|FXR1_uc003fkr.2_Missense_Mutation_p.E33Q|FXR1_uc011bqj.1_Intron|FXR1_uc003fks.2_5'UTR|FXR1_uc011bqk.1_Intron|FXR1_uc011bql.1_Missense_Mutation_p.E20Q	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	33					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			AGTTGTTTTTGAAAATAAGTA	0.338													25	77					0	0	0	0	C	180651167	C	C	180651167	3	2	23	1	0	0	0	0	1	0	0	0	6149	1291	45	2	103	2	FXR1	3	180651167	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1666721	180651167	17371263	97	4712											
EPHB3	2049	broad.mit.edu	37	chr3	184294725	184294725	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggacctgggtggccgggatGacctcctgtacaatgtcatc	7	9	14	11	1	1	1	1	1	0	0	3	3	2	3	4	4	1	1	4	4	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:184294725G>A	uc003foz.2	+	5	1545	c.1108G>A	c.(1108-1110)GAC>AAC	p.D370N		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	370	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TGGCCGGGATGACCTCCTGTA	0.597													24	412					0	0	0	0	A	184294725	A	A	184294725	3	1	23	1	0	0	0	0	1	0	0	0	5200	1290	45	2	1126	2	EPHB3	3	184294725	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3643558	184294725	13727705	98	4713											
C3orf70	285382	broad.mit.edu	37	chr3	184801032	184801032	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctatttttggtgtattgctCtcttttgaaattaaggcatc	8	20	7	6	0	2	1	0	1	2	0	4	1	2	1	0	2	1	3	0	2	4	8			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:184801032C>G	uc003fpd.2	-	2	707	c.516G>C	c.(514-516)GAG>GAC	p.E172D		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	172											0						GTGTATTGCTCTCTTTTGAAA	0.483													17	159					0	0	0	0	G	184801032	G	G	184801032	3	3	23	1	0	0	0	0	1	0	0	0	2252	912	32	2	240	2	C3orf70	3	184801032	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	506307	184801032	13221398	99	4714											
TBCCD1	55171	broad.mit.edu	37	chr3	186274220	186274220	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatgagcccaagccaatttCtttccagacttgaggcaagc	11	10	9	11	0	1	4	0	3	1	1	2	4	2	4	3	1	3	1	3	1	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr3:186274220C>G	uc003fqg.2	-	4	966	c.837G>C	c.(835-837)AAG>AAC	p.K279N	TBCCD1_uc011bry.1_Missense_Mutation_p.K279N|TBCCD1_uc003fqh.2_Missense_Mutation_p.K183N	NM_018138	NP_060608	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	279					cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			large_intestine(1)|ovary(1)	2	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		AAGCCAATTTCTTTCCAGACT	0.353													12	129					0	0	0	0	G	186274220	G	G	186274220	3	3	23	1	0	0	0	0	1	0	0	0	15698	912	32	2	852	2	TBCCD1	3	186274220	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1473188	186274220	11748210	100	4715											
PIGG	54872	broad.mit.edu	37	chr4	514999	514999	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagacgctgagcttgtccctGagtgcacaagtggcccagta	10	8	12	11	1	0	3	0	2	0	1	1	3	1	3	2	1	2	4	2	1	3	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr4:514999G>A	uc003gak.3	+	7	1405	c.1269G>A	c.(1267-1269)CTG>CTA	p.L423L	PIGG_uc003gaj.3_Silent_p.L423L|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Silent_p.L290L|PIGG_uc003gal.3_Silent_p.L334L|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Silent_p.L301L|PIGG_uc003gam.2_Intron|PIGG_uc003gan.2_Silent_p.L334L	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	423	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						GCTTGTCCCTGAGTGCACAAG	0.517													7	85					0	0	0	0	A	514999	A	A	514999	2	1	23	1	0	0	0	0	0	0	0	1	11943	1277	45	2		2	PIGG	4	514999	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08		514999	190639277	101	4716											
AFAP1	60312	broad.mit.edu	37	chr4	7780519	7780519	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccttttcacaacagccgcggGatccgctttctttggctgac	6	12	9	14	3	2	1	1	1	1	0	3	2	3	2	3	2	2	2	3	2	1	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr4:7780519G>A	uc003gkg.1	-	13	1888	c.1615C>T	c.(1615-1617)CCC>TCC	p.P539S	AFAP1_uc011bwk.1_Missense_Mutation_p.P623S|LOC84740_uc003gkd.3_RNA	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	539						actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						ACAGCCGCGGGATCCGCTTTC	0.527													15	147					0	0	0	0	A	7780519	A	A	7780519	3	1	23	1	0	0	0	0	1	0	0	0	353	1174	41	2	597	2	AFAP1	4	7780519	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	7265520	7780519	183373757	102	4717											
DCAF16	54876	broad.mit.edu	37	chr4	17805694	17805694	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccccagaactctcatttaggTaactaatattttcttcttcc	10	16	3	12	0	3	1	1	0	3	1	5	1	4	1	3	1	2	1	3	1	5	9			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr4:17805694T>C	uc003gpn.2	-	3	1132	c.71A>G	c.(70-72)TAC>TGC	p.Y24C	DCAF16_uc003gpo.2_RNA	NM_017741	NP_060211	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	24						CUL4 RING ubiquitin ligase complex				ovary(1)	1						CTCATTTAGGTAACTAATATT	0.438													6	72					0	0	0	0	C	17805694	C	C	17805694	3	2	23	1	0	0	0	0	1	0	0	0	4285	1638	57	5	583	5	DCAF16	4	17805694	Missense_Mutation	SNP	T	TCGA-BB-4223-01A-01D-1434-08	10025175	17805694	173348582	103	4718											
APBB2	323	broad.mit.edu	37	chr4	41016054	41016054	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcagaagttatgttgatGactgcagtggggctcaggtt	8	14	13	6	0	2	3	2	2	1	1	3	3	2	3	0	3	1	5	0	3	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr4:41016054G>A	uc003gvl.2	-	6	1011	c.381C>T	c.(379-381)GTC>GTT	p.V127V	APBB2_uc003gvm.2_Silent_p.V127V|APBB2_uc003gvn.2_Silent_p.V127V|APBB2_uc011byt.1_Silent_p.V110V	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	127					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						TTATGTTGATGACTGCAGTGG	0.527													6	175					0	0	0	0	A	41016054	A	A	41016054	2	1	23	1	0	0	0	0	0	0	0	1	761	1277	45	2		2	APBB2	4	41016054	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	23210360	41016054	150138222	104	4719											
ANKRD17	26057	broad.mit.edu	37	chr4	73951068	73951068	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaaggggtgccccaggtcCgtacatctgacctcctgaaa	9	8	10	14	1	1	2	0	2	1	0	4	2	4	2	6	3	2	1	6	3	3	1	rs139173196		TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr4:73951068C>T	uc003hgp.2	-	30	7174	c.7057G>A	c.(7057-7059)GGA>AGA	p.G2353R	ANKRD17_uc003hgo.2_Missense_Mutation_p.G2240R|ANKRD17_uc003hgq.2_Missense_Mutation_p.G2102R|ANKRD17_uc003hgr.2_Missense_Mutation_p.G2352R	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2353					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GCCCCAGGTCCGTACATCTGA	0.453													18	279					0	0	0	0	T	73951068	T	T	73951068	3	4	23	1	0	0	0	0	1	0	0	0	646	661	23	1	774	1	ANKRD17	4	73951068	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	32935014	73951068	117203208	105	4720											
PDLIM5	10611	broad.mit.edu	37	chr4	95496979	95496979	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccttcacccgtggctgcCgtcactcctcccctgttcgc	2	11	7	21	3	2	0	2	0	0	0	6	0	5	0	7	1	1	2	7	1	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr4:95496979C>T	uc003hti.2	+	5	655	c.504C>T	c.(502-504)GCC>GCT	p.A168A	PDLIM5_uc003htf.2_Intron|PDLIM5_uc003htg.2_Intron|PDLIM5_uc011cdx.1_Intron|PDLIM5_uc003hth.2_Intron|PDLIM5_uc003htj.2_Intron|PDLIM5_uc003htk.2_Intron|PDLIM5_uc011cdy.1_Silent_p.A46A	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	168					regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		CCGTGGCTGCCGTCACTCCTC	0.547													7	218					0	0	0	0	T	95496979	T	T	95496979	2	4	23	1	0	0	0	0	0	0	0	1	11737	639	23	1		1	PDLIM5	4	95496979	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	21545911	95496979	95657297	106	4721											
BANK1	55024	broad.mit.edu	37	chr4	102993520	102993520	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggtaaggaaactgcccacaAtgaaaataagttttataatg	18	10	8	5	0	0	1	0	1	0	0	0	2	0	2	1	2	2	2	1	2	8	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr4:102993520A>G	uc003hvy.3	+	15	2535	c.2261A>G	c.(2260-2262)AAT>AGT	p.N754S	BANK1_uc003hvx.3_Missense_Mutation_p.N739S|BANK1_uc010ill.2_Missense_Mutation_p.N621S|BANK1_uc003hvz.3_Missense_Mutation_p.N724S	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	754					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		ACTGCCCACAATGAAAATAAG	0.254													6	215					0	0	0	0	G	102993520	G	G	102993520	3	3	23	1	0	0	0	0	1	0	0	0	1311	101	4	5	2319	5	BANK1	4	102993520	Missense_Mutation	SNP	A	TCGA-BB-4223-01A-01D-1434-08	7496541	102993520	88160756	107	4722											
GLRB	2743	broad.mit.edu	37	chr4	158073943	158073943	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcccaaagtttcctatgtGaaggctcttgatgtttggct	7	16	9	9	0	1	2	0	2	1	0	3	2	3	2	2	2	0	4	2	2	3	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr4:158073943G>T	uc003ipj.2	+	9	1180	c.978G>T	c.(976-978)GTG>GTT	p.V326V		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	326					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	TTTCCTATGTGAAGGCTCTTG	0.488													8	209					0.000157383	0.000160898	1	0	T	158073943	T	T	158073943	2	4	23	1	0	0	0	0	0	0	0	1	6495	1277	45	2		2	GLRB	4	158073943	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	55080423	158073943	33080333	108	4723											
CDKN2AIP	55602	broad.mit.edu	37	chr4	184367348	184367348	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacagaacgtgcatcagctCagcaggaaaacagttcaacg	16	5	10	10	2	3	2	3	0	0	2	3	3	3	3	0	1	6	4	0	1	4	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr4:184367348C>T	uc003ivp.1	+	3	673	c.511C>T	c.(511-513)CAG>TAG	p.Q171*	CDKN2AIP_uc003ivq.1_5'UTR	NM_017632	NP_060102	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	171					negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding				0		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		TGCATCAGCTCAGCAGGAAAA	0.468													5	149					0	0	0	0	T	184367348	T	T	184367348	4	4	23	1	0	0	0	0	0	1	0	0	3177	827	29	2	521	2	CDKN2AIP	4	184367348	Nonsense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	26293405	184367348	6786928	109	4724											
SNX25	83891	broad.mit.edu	37	chr4	186272652	186272652	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagcactttatgccttcttGagcccttctcctgactacct	7	14	6	14	0	2	2	0	2	2	0	3	3	2	2	4	0	4	1	4	0	3	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr4:186272652G>C	uc003ixh.2	+	14	2052	c.1863G>C	c.(1861-1863)TTG>TTC	p.L621F	SNX25_uc010ish.2_Intron|SNX25_uc003ixi.2_Missense_Mutation_p.L125F	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	621	PX.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		ATGCCTTCTTGAGCCCTTCTC	0.418													18	274					0	0	0	0	C	186272652	C	C	186272652	3	2	23	1	0	0	0	0	1	0	0	0	14960	1281	45	2	1913	2	SNX25	4	186272652	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1905304	186272652	4881624	110	4725											
DNAH5	1767	broad.mit.edu	37	chr5	13901452	13901452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaattataggtttggcttctGccgtgcttagcacagctggg	7	13	13	8	1	1	0	0	0	1	0	1	1	1	0	1	3	4	5	1	3	4	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:13901452G>A	uc003jfd.2	-	14	2003	c.1961C>T	c.(1960-1962)GCA>GTA	p.A654V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	654	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTTGGCTTCTGCCGTGCTTAG	0.562									Kartagener_syndrome				4	92					0	0	0	0	A	13901452	A	A	13901452	3	1	23	1	0	0	0	0	1	0	0	0	4626	1319	46	4	12177	4	DNAH5	5	13901452	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08		13901452	167013808	111	4726											
CDH9	1007	broad.mit.edu	37	chr5	26890572	26890572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taacagtgatgttatgccaaGgagatgattcccggtcaagg	12	10	12	7	1	1	3	1	2	0	1	2	4	2	3	2	3	2	1	2	3	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:26890572G>A	uc003jgs.1	-	8	1524	c.1355C>T	c.(1354-1356)CCT>CTT	p.P452L	CDH9_uc011cnv.1_Missense_Mutation_p.P45L	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	452	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GTTATGCCAAGGAGATGATTC	0.398													10	225					0	0	0	0	A	26890572	A	A	26890572	3	1	23	1	0	0	0	0	1	0	0	0	3132	1000	35	4	1034	4	CDH9	5	26890572	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	12989120	26890572	154024688	112	4727											
RAI14	26064	broad.mit.edu	37	chr5	34814701	34814701	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttagttgagtgatgtctCttccccaagatcaataactt	10	17	6	8	0	2	3	1	2	1	1	4	3	3	3	2	0	1	1	2	0	4	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:34814701C>T	uc003jir.2	+	12	1062	c.866C>T	c.(865-867)TCT>TTT	p.S289F	RAI14_uc010iur.2_Missense_Mutation_p.S260F|RAI14_uc011coj.1_Missense_Mutation_p.S289F|RAI14_uc010ius.1_Missense_Mutation_p.S218F|RAI14_uc003jis.2_Missense_Mutation_p.S292F|RAI14_uc003jit.2_Missense_Mutation_p.S289F|RAI14_uc011cok.1_Missense_Mutation_p.S281F	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	289						cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					AGTGATGTCTCTTCCCCAAGA	0.363													7	197					0	0	0	0	T	34814701	T	T	34814701	3	4	23	1	0	0	0	0	1	0	0	0	13073	913	32	2	973	2	RAI14	5	34814701	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	7924129	34814701	146100559	113	4728											
MAP1B	4131	broad.mit.edu	37	chr5	71494638	71494638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttgccacagttcctcttCtccaccaatagatgcagcat	11	11	5	14	0	2	1	0	0	2	1	4	1	3	1	4	0	4	3	4	0	3	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:71494638C>T	uc003kbw.3	+	5	5697	c.5456C>T	c.(5455-5457)TCT>TTT	p.S1819F	MAP1B_uc010iyw.1_Missense_Mutation_p.S1836F|MAP1B_uc010iyx.1_Missense_Mutation_p.S1693F|MAP1B_uc010iyy.1_Missense_Mutation_p.S1693F	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1819						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AGTTCCTCTTCTCCACCAATA	0.468													6	120					0	0	0	0	T	71494638	T	T	71494638	3	4	23	1	0	0	0	0	1	0	0	0	9281	913	32	2	5474	2	MAP1B	5	71494638	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	36679937	71494638	109420622	114	4729											
COL4A3BP	10087	broad.mit.edu	37	chr5	74712757	74712757	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccattagttcaatacaatGagaaagtgttgcaaggattc	16	11	8	6	0	1	1	1	1	0	1	2	3	1	2	1	1	3	3	1	1	7	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:74712757G>A	uc011csu.1	-	7	1203	c.781C>T	c.(781-783)CAT>TAT	p.H261Y	COL4A3BP_uc003kds.2_Missense_Mutation_p.H261Y|COL4A3BP_uc003kdt.2_Missense_Mutation_p.H389Y|COL4A3BP_uc003kdu.2_Missense_Mutation_p.H261Y	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	261					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		TCAATACAATGAGAAAGTGTT	0.353													6	272					0	0	0	0	A	74712757	A	A	74712757	3	1	23	1	0	0	0	0	1	0	0	0	3707	1290	45	2	1137	2	COL4A3BP	5	74712757	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3218119	74712757	106202503	115	4730											
FNIP1	96459	broad.mit.edu	37	chr5	131007934	131007934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagcaggcacaatcttatCtggaggttttttttccacaa	11	14	8	8	0	2	1	0	1	2	0	3	2	3	2	1	3	1	3	1	3	4	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:131007934C>T	uc003kvs.1	-	14	2345	c.2203G>A	c.(2203-2205)GAT>AAT	p.D735N	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.D707N|FNIP1_uc010jdm.1_Missense_Mutation_p.D690N	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	735					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		ACAATCTTATCTGGAGGTTTT	0.448													10	429					0	0	0	0	T	131007934	T	T	131007934	3	4	23	1	0	0	0	0	1	0	0	0	6007	913	32	2	1317	2	FNIP1	5	131007934	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	56295177	131007934	49907326	116	4731											
TGFBI	7045	broad.mit.edu	37	chr5	135391456	135391456	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgatggaccgggtgctgaccCccccaatggggactgtcatg	7	7	14	13	2	1	1	1	1	0	0	1	4	1	3	4	4	1	1	4	4	1	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:135391456C>A	uc003lbf.3	+	11	1659	c.1498C>A	c.(1498-1500)CCC>ACC	p.P500T	TGFBI_uc003lbg.3_Missense_Mutation_p.P233T|TGFBI_uc003lbh.3_Missense_Mutation_p.P326T|TGFBI_uc011cyb.1_Missense_Mutation_p.P326T|TGFBI_uc010jed.2_Missense_Mutation_p.P233T	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	500					angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTGCTGACCCCCCCAATGGG	0.587													29	51					5.45727e-16	5.70659e-16	1	0	A	135391456	A	A	135391456	3	1	23	1	0	0	0	0	1	0	0	0	15886	623	22	4	1540	4	TGFBI	5	135391456	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	4383522	135391456	45523804	117	4732											
FAM13B	51306	broad.mit.edu	37	chr5	137354085	137354085	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctaagaaggctaatagctgaGggaacatctgcttccttaac	13	10	9	9	0	1	2	0	1	1	1	2	3	2	3	1	2	4	3	1	2	6	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:137354085G>A	uc003lbz.2	-	4	810	c.276C>T	c.(274-276)CCC>CCT	p.P92P	FAM13B_uc003lcb.2_5'UTR|FAM13B_uc003lca.2_Silent_p.P92P	NM_016603	NP_057687	Q9NYF5	FA13B_HUMAN	hypothetical protein LOC51306 isoform 1	92	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						TAATAGCTGAGGGAACATCTG	0.433													10	202					0	0	0	0	A	137354085	A	A	137354085	2	1	23	1	0	0	0	0	0	0	0	1	5481	987	35	4		4	FAM13B	5	137354085	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1962629	137354085	43561175	118	4733											
CTNNA1	1495	broad.mit.edu	37	chr5	138118956	138118956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgttttggctgcatctgttGaacaagcaactgagaatttc	11	14	9	7	0	1	2	0	2	1	1	2	3	1	2	0	1	4	5	0	1	4	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:138118956G>A	uc003ldh.2	+	3	291	c.196G>A	c.(196-198)GAA>AAA	p.E66K	CTNNA1_uc011cyx.1_Intron|CTNNA1_uc011cyy.1_5'UTR|CTNNA1_uc003ldi.2_Silent_p.L7L|CTNNA1_uc003ldj.2_Missense_Mutation_p.E66K	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	66	Involved in homodimerization.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGCATCTGTTGAACAAGCAAC	0.433													7	197					0	0	0	0	A	138118956	A	A	138118956	3	1	23	1	0	0	0	0	1	0	0	0	4029	1291	45	2	202	2	CTNNA1	5	138118956	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	764871	138118956	42796304	119	4734											
PCDHA10	56139	broad.mit.edu	37	chr5	140237154	140237154	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctcgctgtcgagctacgtGtcggtgcacgcggagagcgg	5	7	17	12	8	0	1	0	0	0	1	3	3	0	1	0	3	4	4	0	3	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:140237154G>T	uc003lhx.2	+	1	1521	c.1521G>T	c.(1519-1521)GTG>GTT	p.V507V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.V507V|PCDHA10_uc011dad.1_Silent_p.V507V	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	507	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAGCTACGTGTCGGTGCACG	0.692													9	237					7.48243e-07	7.72622e-07	1	0	T	140237154	T	T	140237154	2	4	23	1	0	0	0	0	0	0	0	1	11574	1364	48	4		4	PCDHA10	5	140237154	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2118198	140237154	40678106	120	4735											
PCDHB16	57717	broad.mit.edu	37	chr5	140563086	140563086	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggttacgtcttatgaagtgCgcatcaaagccacagatggg	11	10	12	8	2	2	2	1	1	1	1	2	2	2	2	1	2	3	2	1	2	4	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:140563086C>T	uc003liv.2	+	1	2107	c.952C>T	c.(952-954)CGC>TGC	p.R318C	PCDHB16_uc010jfw.1_Intron	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	318	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTATGAAGTGCGCATCAAAGC	0.473													12	183					0	0	0	0	T	140563086	T	T	140563086	3	4	23	1	0	0	0	0	1	0	0	0	11595	768	27	1	954	1	PCDHB16	5	140563086	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	325932	140563086	40352174	121	4736											
ARAP3	64411	broad.mit.edu	37	chr5	141041787	141041787	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcaggctgcgggcacgagCgccccctttccggtatacac	6	8	11	16	4	1	0	1	0	1	0	3	1	2	0	3	3	3	3	3	3	2	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:141041787C>T	uc003llm.2	-	20	2914	c.2836G>A	c.(2836-2838)GCT>ACT	p.A946T	ARAP3_uc003lll.2_5'UTR|ARAP3_uc011dbe.1_Missense_Mutation_p.A608T|ARAP3_uc003lln.2_Intron	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	946	Rho-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CGGGCACGAGCGCCCCCTTTC	0.642													8	318					0	0	0	0	T	141041787	T	T	141041787	3	4	23	1	0	0	0	0	1	0	0	0	840	768	27	1	1854	1	ARAP3	5	141041787	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	478701	141041787	39873473	122	4737											
ARAP3	64411	broad.mit.edu	37	chr5	141059994	141059994	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtcggaacgtgtctgcataCtgctccaggtgcaccgtggc	6	9	13	13	4	1	0	0	0	1	0	3	1	2	1	2	3	5	3	2	3	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:141059994C>G	uc003llm.2	-	2	138	c.60G>C	c.(58-60)CAG>CAC	p.Q20H	ARAP3_uc003lln.2_5'UTR|ARAP3_uc003llo.1_Missense_Mutation_p.Q20H	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	20	SAM.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						TGTCTGCATACTGCTCCAGGT	0.677													5	121					0	0	0	0	G	141059994	G	G	141059994	3	3	23	1	0	0	0	0	1	0	0	0	840	564	20	4	4702	4	ARAP3	5	141059994	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	18207	141059994	39855266	123	4738											
HAVCR2	84868	broad.mit.edu	37	chr5	156522384	156522384	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagatccctgctccgatgtaGatgcctattctgatggttgc	7	13	10	11	1	1	3	0	1	1	2	3	4	3	3	3	1	3	3	3	1	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:156522384G>A	uc003lwk.1	-	5	753	c.609C>T	c.(607-609)ATC>ATT	p.I203I		NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	203	Helical; (Potential).					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTCCGATGTAGATGCCTATTC	0.453													5	226					0	0	0	0	A	156522384	A	A	156522384	2	1	23	1	0	0	0	0	0	0	0	1	7013	932	33	2		2	HAVCR2	5	156522384	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	15462390	156522384	24392876	124	4739											
ODZ2	57451	broad.mit.edu	37	chr5	167622191	167622191	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttctcagcttggtttctCtcatccgaggccaagtagta	7	15	8	11	1	4	0	2	0	3	0	7	1	5	0	2	2	1	4	2	2	3	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr5:167622191C>G	uc010jjd.2	+	15	2764	c.2764C>G	c.(2764-2766)CTC>GTC	p.L922V	ODZ2_uc003lzr.3_Missense_Mutation_p.L699V|ODZ2_uc003lzt.3_Missense_Mutation_p.L295V|ODZ2_uc010jje.2_Missense_Mutation_p.L193V	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CTTGGTTTCTCTCATCCGAGG	0.507													3	45					0	0	0	0	G	167622191	G	G	167622191	3	3	23	1	0	0	0	0	1	0	0	0	10889	913	32	2	2822	2	ODZ2	5	167622191	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	11099807	167622191	13293069	125	4740											
RPP40	10799	broad.mit.edu	37	chr6	4996630	4996630	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggtacttggaaaaatatGacatcattgtcgattcttct	11	17	7	6	1	3	1	1	1	2	0	4	3	3	2	0	2	1	1	0	2	4	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:4996630G>A	uc003mwl.2	-	6	619	c.584C>T	c.(583-585)TCA>TTA	p.S195L	RPP40_uc003mwm.2_Missense_Mutation_p.S172L	NM_006638	NP_006629	O75818	RPP40_HUMAN	ribonuclease P 40kDa subunit	195					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0895)				GGAAAAATATGACATCATTGT	0.458													5	130					0	0	0	0	A	4996630	A	A	4996630	3	1	23	1	0	0	0	0	1	0	0	0	13679	1294	45	2	519	2	RPP40	6	4996630	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08		4996630	166118437	126	4741											
DSP	1832	broad.mit.edu	37	chr6	7569567	7569567	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccactggccgtggacctctCttgcaagtaagtcatccaag	9	9	9	14	1	2	0	1	0	1	0	4	1	3	1	4	2	1	2	4	2	3	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:7569567C>G	uc003mxp.1	+	12	1847	c.1568C>G	c.(1567-1569)TCT>TGT	p.S523C	DSP_uc003mxq.1_Missense_Mutation_p.S523C	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	523	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GTGGACCTCTCTTGCAAGTAA	0.572													6	173					0	0	0	0	G	7569567	G	G	7569567	3	3	23	1	0	0	0	0	1	0	0	0	4803	913	32	2	1614	2	DSP	6	7569567	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2572937	7569567	163545500	127	4742											
DSP	1832	broad.mit.edu	37	chr6	7572178	7572178	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcaagaaacatggatgctGatggagctgcagaagattcg	15	7	13	6	1	0	4	0	1	0	3	1	6	0	6	0	2	5	4	0	2	4	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:7572178G>A	uc003mxp.1	+	15	2286	c.2007G>A	c.(2005-2007)CTG>CTA	p.L669L	DSP_uc003mxq.1_Silent_p.L669L	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	669	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CATGGATGCTGATGGAGCTGC	0.458													6	118					0	0	0	0	A	7572178	A	A	7572178	2	1	23	1	0	0	0	0	0	0	0	1	4803	1277	45	2		2	DSP	6	7572178	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2611	7572178	163542889	128	4743											
SYCP2L	221711	broad.mit.edu	37	chr6	10911091	10911091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtgtattgctgcttttgctGatgagcatgaggtatgttca	7	16	12	6	1	1	3	1	3	0	0	1	3	1	3	0	1	4	7	0	1	2	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:10911091G>A	uc003mzo.2	+	12	1203	c.907G>A	c.(907-909)GAT>AAT	p.D303N	SYCP2L_uc011din.1_Missense_Mutation_p.D144N|SYCP2L_uc010jow.2_Intron	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	303						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TGCTTTTGCTGATGAGCATGA	0.408													126	225					0	0	0	0	A	10911091	A	A	10911091	3	1	23	1	0	0	0	0	1	0	0	0	15499	1290	45	2	953	2	SYCP2L	6	10911091	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3338913	10911091	160203976	129	4744											
HIST1H2BD	3017	broad.mit.edu	37	chr6	26158465	26158465	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggcggtgactaaggctcAgaagaaggacgggaagaagc	15	3	17	6	2	1	4	1	1	0	3	1	7	1	6	0	5	1	1	0	5	6	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:26158465A>T	uc003ngr.2	+	1	117	c.68A>T	c.(67-69)CAG>CTG	p.Q23L	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.Q23L	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	23					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						ACTAAGGCTCAGAAGAAGGAC	0.532													11	303					0	0	0	0	T	26158465	T	T	26158465	3	4	23	1	0	0	0	0	1	0	0	0	7182	188	7	5	70	5	HIST1H2BD	6	26158465	Missense_Mutation	SNP	A	TCGA-BB-4223-01A-01D-1434-08	15247374	26158465	144956602	130	4745											
HIST1H2BH	8345	broad.mit.edu	37	chr6	26251947	26251947	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggcggtgaccaaggcgcaGaagaaggatggcaagaagcg	15	2	17	7	3	0	4	0	1	0	3	0	5	0	5	1	5	1	2	1	5	6	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:26251947G>C	uc003nhh.2	+	1	69	c.69G>C	c.(67-69)CAG>CAC	p.Q23H	HIST1H3F_uc003nhg.1_5'Flank	NM_003524	NP_003515	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	23					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)	3						CCAAGGCGCAGAAGAAGGATG	0.552													13	233					0	0	0	0	C	26251947	C	C	26251947	3	2	23	1	0	0	0	0	1	0	0	0	7186	933	33	2	71	2	HIST1H2BH	6	26251947	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	93482	26251947	144863120	131	4746											
SLC26A8	116369	broad.mit.edu	37	chr6	35927554	35927554	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtaattgagctgcagcactgGaagattttcaccccaggaat	12	10	10	9	0	1	2	1	1	0	1	1	4	1	4	2	2	3	4	2	2	3	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:35927554G>C	uc003olm.2	-	15	1779	c.1668C>G	c.(1666-1668)TTC>TTG	p.F556L	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.F138L|SLC26A8_uc003oln.2_Missense_Mutation_p.F556L|SLC26A8_uc003oll.2_Missense_Mutation_p.F451L	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	556	STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						TGCAGCACTGGAAGATTTTCA	0.393													4	164					0	0	0	0	C	35927554	C	C	35927554	3	2	23	1	0	0	0	0	1	0	0	0	14587	1165	41	2	1268	2	SLC26A8	6	35927554	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	9675607	35927554	135187513	132	4747											
ZFAND3	60685	broad.mit.edu	37	chr6	37897761	37897761	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caagactatgaatctctgttCcaaatgctttgctggtaagt	11	14	8	8	0	1	2	0	1	1	1	3	2	2	2	1	1	2	4	1	1	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:37897761C>G	uc003onx.2	+	2	513	c.98C>G	c.(97-99)TCC>TGC	p.S33C		NM_021943	NP_068762	Q9H8U3	ZFAN3_HUMAN	zinc finger, AN1-type domain 3	33	A20-type.						DNA binding|zinc ion binding			ovary(1)	1						AATCTCTGTTCCAAATGCTTT	0.269													6	237					0	0	0	0	G	37897761	G	G	37897761	3	3	23	1	0	0	0	0	1	0	0	0	17696	855	30	2	104	2	ZFAND3	6	37897761	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1970207	37897761	133217306	133	4748											
DNAH8	1769	broad.mit.edu	37	chr6	38950169	38950169	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaatattccctacgaattCaattctgctgacttttcagc	10	15	6	10	1	3	1	2	1	1	0	4	3	4	2	1	1	3	1	1	1	5	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:38950169C>T	uc003ooe.1	+	84	12831	c.12231C>T	c.(12229-12231)TTC>TTT	p.F4077F	DNAH8_uc003oog.1_Silent_p.F526F	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CCTACGAATTCAATTCTGCTG	0.353													10	277					0	0	0	0	T	38950169	T	T	38950169	2	4	23	1	0	0	0	0	0	0	0	1	4629	825	29	2		2	DNAH8	6	38950169	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1052408	38950169	132164898	134	4749											
PPP2R5D	5528	broad.mit.edu	37	chr6	42978724	42978724	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagaggactgtggagactGaggctgttcaggtgggaggg	9	8	20	4	0	1	4	1	2	0	2	1	7	1	6	0	6	0	2	0	6	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:42978724G>A	uc003oth.2	+	15	1746	c.1660G>A	c.(1660-1662)GAG>AAG	p.E554K	MEA1_uc010jyc.1_Intron|PPP2R5D_uc003otg.2_Missense_Mutation_p.E522K|PPP2R5D_uc010jyd.2_Missense_Mutation_p.E448K|PPP2R5D_uc011dva.1_Missense_Mutation_p.E403K|PPP2R5D_uc003oti.2_Missense_Mutation_p.E403K|PPP2R5D_uc003otj.2_Missense_Mutation_p.E385K	NM_006245	NP_006236	Q14738	2A5D_HUMAN	delta isoform of regulatory subunit B56, protein	554	Nuclear localization signal (Potential).				nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			breast(1)|central_nervous_system(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TGTGGAGACTGAGGCTGTTCA	0.557													8	193					0	0	0	0	A	42978724	A	A	42978724	3	1	23	1	0	0	0	0	1	0	0	0	12455	1291	45	2	1718	2	PPP2R5D	6	42978724	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4028555	42978724	128136343	135	4750											
TTBK1	84630	broad.mit.edu	37	chr6	43222389	43222389	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accacgggggatgtgcggccCgtgagtaccgtcggggcggg	5	5	20	11	6	0	1	0	1	0	0	1	2	0	2	3	6	2	1	3	6	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:43222389C>T	uc003ouq.1	+	6	855	c.576C>T	c.(574-576)CCC>CCT	p.P192P		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	192	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			ATGTGCGGCCCGTGAGTACCG	0.627													6	111					0	0	0	0	T	43222389	T	T	43222389	2	4	23	1	0	0	0	0	0	0	0	1	16744	666	23	1		1	TTBK1	6	43222389	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	243665	43222389	127892678	136	4751											
TCTE1	202500	broad.mit.edu	37	chr6	44254175	44254175	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtagttctcactgtctatCaggttggcggtcacagccag	8	11	11	11	1	4	0	3	0	2	0	5	0	4	0	1	3	1	3	1	3	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:44254175C>G	uc003oxi.2	-	3	528	c.372G>C	c.(370-372)CTG>CTC	p.L124L	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	124										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CACTGTCTATCAGGTTGGCGG	0.592													10	311					0	0	0	0	G	44254175	G	G	44254175	2	3	23	1	0	0	0	0	0	0	0	1	15783	813	29	2		2	TCTE1	6	44254175	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1031786	44254175	126860892	137	4752											
CDC5L	988	broad.mit.edu	37	chr6	44371637	44371637	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaagagaggagttgattatAatgccgaaatcccatttgaa	15	10	11	5	1	0	3	0	2	0	1	1	7	1	5	2	2	1	1	2	2	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:44371637A>T	uc003oxl.2	+	6	890	c.631A>T	c.(631-633)AAT>TAT	p.N211Y		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	211	Potential.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AGTTGATTATAATGCCGAAAT	0.393													64	64					0	0	0	0	T	44371637	T	T	44371637	3	4	23	1	0	0	0	0	1	0	0	0	3097	362	13	5	653	5	CDC5L	6	44371637	Missense_Mutation	SNP	A	TCGA-BB-4223-01A-01D-1434-08	117462	44371637	126743430	138	4753											
PLA2G7	7941	broad.mit.edu	37	chr6	46673033	46673033	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcaaaattctggtggactGaacccctaaaagagaacaag	17	6	9	9	0	1	2	0	1	1	1	1	4	1	3	2	2	3	1	2	2	7	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:46673033G>A	uc010jzf.2	-	11	1315	c.1046C>T	c.(1045-1047)TCA>TTA	p.S349L	PLA2G7_uc010jzg.1_Nonsense_Mutation_p.Q286*	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	349					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			CTGGTGGACTGAACCCCTAAA	0.333													4	70					0	0	0	0	A	46673033	A	A	46673033	3	1	23	1	0	0	0	0	1	0	0	0	12064	1294	45	2	287	2	PLA2G7	6	46673033	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2301396	46673033	124442034	139	4754											
DST	667	broad.mit.edu	37	chr6	56357812	56357812	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttagggtctgttcagcctGagtaagccagttgatgaagt	10	13	12	6	0	2	3	1	3	1	0	2	3	2	3	2	1	2	3	2	1	3	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:56357812G>A	uc003pdf.2	-	78	14141	c.14113C>T	c.(14113-14115)CAG>TAG	p.Q4705*	DST_uc003pcz.3_Nonsense_Mutation_p.Q4527*|DST_uc011dxj.1_Nonsense_Mutation_p.Q4556*|DST_uc011dxk.1_Nonsense_Mutation_p.Q4567*|DST_uc003pcy.3_Nonsense_Mutation_p.Q4201*|DST_uc003pda.3_5'Flank	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6613	Spectrin 17.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGTTCAGCCTGAGTAAGCCAG	0.428													5	37					0	0	0	0	A	56357812	A	A	56357812	4	1	23	1	0	0	0	0	0	1	0	0	4805	1299	45	2	2994	2	DST	6	56357812	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	9684779	56357812	114757255	140	4755											
DST	667	broad.mit.edu	37	chr6	56513371	56513371	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctacagtgacactaaccttCagttctacaggattattagg	12	13	7	9	0	3	1	1	1	2	0	3	2	3	2	1	2	3	1	1	2	5	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:56513371C>G	uc003pdf.2	-	12	1480	c.1452G>C	c.(1450-1452)CTG>CTC	p.L484L	DST_uc003pcz.3_Silent_p.L306L|DST_uc011dxj.1_Silent_p.L335L|DST_uc011dxk.1_Silent_p.L346L|DST_uc011dxl.1_Silent_p.L335L|DST_uc003pde.2_Silent_p.L422L	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	306					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CACTAACCTTCAGTTCTACAG	0.333													3	20					0	0	0	0	G	56513371	G	G	56513371	2	3	23	1	0	0	0	0	0	0	0	1	4805	841	29	2		2	DST	6	56513371	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	155559	56513371	114601696	141	4756											
KHDC1	80759	broad.mit.edu	37	chr6	73952217	73952217	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccaccacggcttcttgctGagagcactcgttcccatgtc	6	11	9	15	2	1	1	0	1	1	1	5	2	3	1	3	1	2	4	3	1	0	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:73952217G>A	uc003pgo.2	-	3	744	c.243C>T	c.(241-243)CTC>CTT	p.L81L	KHDC1_uc011dyl.1_RNA|KHDC1_uc003pgn.3_Silent_p.L8L	NM_030568	NP_085045	Q4VXA5	KHDC1_HUMAN	KH homology domain containing 1	81						integral to membrane	RNA binding			skin(1)	1						GCTTCTTGCTGAGAGCACTCG	0.527													11	229					0	0	0	0	A	73952217	A	A	73952217	2	1	23	1	0	0	0	0	0	0	0	1	8183	1277	45	2		2	KHDC1	6	73952217	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	17438846	73952217	97162850	142	4757											
PHIP	55023	broad.mit.edu	37	chr6	79787178	79787178	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtctcaccagattctggtagGtcctgggatgctccttcccg	5	12	11	13	1	2	1	1	0	2	1	6	2	5	2	4	3	1	2	4	3	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:79787178G>A	uc003pir.2	-	4	402	c.176C>T	c.(175-177)ACC>ATC	p.T59I	PHIP_uc011dyp.1_Missense_Mutation_p.T59I	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	59					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		ATTCTGGTAggtcctgggatg	0.184													8	171					0	0	0	0	A	79787178	A	A	79787178	3	1	23	1	0	0	0	0	1	0	0	0	11897	1261	44	4	5437	4	PHIP	6	79787178	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	5834961	79787178	91327889	143	4758											
SIM1	6492	broad.mit.edu	37	chr6	100901696	100901696	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagggggctggtccgacttGagtggccccacgcctcgccg	4	6	15	16	4	0	1	0	1	0	0	2	2	1	1	6	4	0	1	6	4	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:100901696G>C	uc003pqj.3	-	2	407	c.200C>G	c.(199-201)TCA>TGA	p.S67*	SIM1_uc010kcu.2_Nonsense_Mutation_p.S67*	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	67					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GGTCCGACTTGAGTGGCCCCA	0.617													52	106					0	0	0	0	C	100901696	C	C	100901696	4	2	23	1	0	0	0	0	0	1	0	0	14388	1294	45	2	2140	2	SIM1	6	100901696	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	21114518	100901696	70213371	144	4759											
SOBP	55084	broad.mit.edu	37	chr6	107956425	107956425	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggccaaaaagctgatgggcGaggaggccctggcggggggc	8	3	20	10	3	0	1	0	1	0	0	0	3	0	2	2	8	1	1	2	8	2	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:107956425G>A	uc003prx.2	+	6	2881	c.2377G>A	c.(2377-2379)GAG>AAG	p.E793K		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	793							metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GCTGATGGGCGAGGAGGCCCT	0.632													7	162					0	0	0	0	A	107956425	A	A	107956425	3	1	23	1	0	0	0	0	1	0	0	0	14976	1059	37	1	2399	1	SOBP	6	107956425	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	7054729	107956425	63158642	145	4760											
PTPRK	5796	broad.mit.edu	37	chr6	128291404	128291404	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtactccaaagctacatCatagcagaaacggtattgct	14	9	8	10	1	1	1	1	0	0	1	2	1	2	1	1	2	6	5	1	2	6	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:128291404C>T	uc003qbk.2	-	30	4655	c.4288G>A	c.(4288-4290)GAT>AAT	p.D1430N	PTPRK_uc003qbj.2_Missense_Mutation_p.D1431N|PTPRK_uc010kfc.2_Missense_Mutation_p.D1437N|PTPRK_uc011ebu.1_Missense_Mutation_p.D1453N	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1430	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		AAAGCTACATCATAGCAGAAA	0.383													5	106					0	0	0	0	T	128291404	T	T	128291404	3	4	23	1	0	0	0	0	1	0	0	0	12870	826	29	2	35	2	PTPRK	6	128291404	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	20334979	128291404	42823663	146	4761											
CNKSR3	154043	broad.mit.edu	37	chr6	154831247	154831248	+	Frame_Shift_Ins	INS	-	G	G																															ccacttggtcacgggttccaINStggtaaaccgcttcgcctct																										TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:154831247_154831248insG	uc003qpy.2	-	1	506_507	c.1_2insC	c.(1-3)ATGfs	p.M1fs		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	1					negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		CACGGGTTCCATGGTAAACCGC	0.683													---	---	---								G	154831248	G	G	154831247	7	5	23	1	0	1	1	0	0	0	0	0	3623	217	8	0	1717	0	CNKSR3	6	154831247	Frame_Shift_Ins	INS	-	TCGA-BB-4223-01A-01D-1434-08	26539843	154831247	16283820	147	4762											
TIAM2	26230	broad.mit.edu	37	chr6	155450635	155450635	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggtgttgcctactccaCgcacaggacaaatgccccag	11	6	10	14	1	0	1	0	0	0	1	1	2	1	2	4	2	3	2	4	2	2	2	rs141887143		TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:155450635C>T	uc003qqb.2	+	6	1551	c.278C>T	c.(277-279)ACG>ATG	p.T93M	TIAM2_uc003qqe.2_Missense_Mutation_p.T93M	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	93					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GCCTACTCCACGCACAGGACA	0.552													5	76					0	0	0	0	T	155450635	T	T	155450635	3	4	23	1	0	0	0	0	1	0	0	0	15957	536	19	1	280	1	TIAM2	6	155450635	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	619388	155450635	15664432	148	4763											
PNLDC1	154197	broad.mit.edu	37	chr6	160222178	160222178	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatcggagtggtatctaaaGacccgtcagagtgttcagca	11	9	11	10	2	3	2	2	0	1	2	4	3	3	3	2	2	1	3	2	2	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr6:160222178G>C	uc003qsx.1	+	3	306	c.135G>C	c.(133-135)AAG>AAC	p.K45N	PNLDC1_uc003qsy.1_Missense_Mutation_p.K56N	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	45	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		GGTATCTAAAGACCCGTCAGA	0.433													16	440					0	0	0	0	C	160222178	C	C	160222178	3	2	23	1	0	0	0	0	1	0	0	0	12203	933	33	2	141	2	PNLDC1	6	160222178	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4771543	160222178	10892889	149	4764											
IQCE	23288	broad.mit.edu	37	chr7	2623917	2623917	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttctgaaaccaccggaaaGaagtatgatggccgcttgca	13	8	11	9	2	1	3	0	2	1	1	1	4	1	4	3	2	2	4	3	2	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:2623917G>A	uc003smo.3	+	11	1006	c.822G>A	c.(820-822)AAG>AAA	p.K274K	IQCE_uc010ksm.1_Silent_p.K274K|IQCE_uc003sml.1_Silent_p.K274K|IQCE_uc011jvy.1_Silent_p.K258K|IQCE_uc011jvz.1_Silent_p.K209K|IQCE_uc003smk.3_Silent_p.K258K|IQCE_uc003smn.3_Silent_p.K209K	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	274											0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		CCACCGGAAAGAAGTATGATG	0.483													10	293					0	0	0	0	A	2623917	A	A	2623917	2	1	23	1	0	0	0	0	0	0	0	1	7845	933	33	2		2	IQCE	7	2623917	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08		2623917	156514746	150	4765											
TMEM196	256130	broad.mit.edu	37	chr7	19765224	19765224	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taactggctagtcgacaagtGagccaggaagagagagtgca	14	6	14	7	1	0	3	0	1	0	2	1	6	0	4	1	2	3	2	1	2	4	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:19765224G>T	uc011jyg.1	-	3	457	c.372C>A	c.(370-372)CTC>CTA	p.L124L	TMEM196_uc003sur.2_RNA	NM_152774	NP_689987	Q5HYL7	TM196_HUMAN	transmembrane protein 196	130						integral to membrane					0						GTCGACAAGTGAGCCAGGAAG	0.512													6	107					0.00116845	0.00118864	1	0	T	19765224	T	T	19765224	2	4	23	1	0	0	0	0	0	0	0	1	16184	1277	45	2		2	TMEM196	7	19765224	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	17141307	19765224	139373439	151	4766											
HOXA4	3201	broad.mit.edu	37	chr7	27169017	27169017	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacttcatcctccggttctGaaaccagatcttgacctggc	8	11	7	15	1	3	3	1	2	2	1	5	3	5	3	5	2	1	1	5	2	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:27169017G>C	uc003sym.3	-	2	837	c.790C>G	c.(790-792)CAG>GAG	p.Q264E	HOXA3_uc003syk.2_5'Flank	NM_002141	NP_002132	Q00056	HXA4_HUMAN	homeobox A4	264	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CTCCGGTTCTGAAACCAGATC	0.582													11	245					0	0	0	0	C	27169017	C	C	27169017	3	2	23	1	0	0	0	0	1	0	0	0	7333	1299	45	2	176	2	HOXA4	7	27169017	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	7403793	27169017	131969646	152	4767											
EGFR	1956	broad.mit.edu	37	chr7	55240703	55240703	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atcccgtccatcgccactggGatggtgggggccctcctctt	4	10	12	15	2	1	0	0	0	1	0	5	1	4	1	5	4	0	0	5	4	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:55240703G>A	uc003tqk.2	+	17	2193	c.1947G>A	c.(1945-1947)GGG>GGA	p.G649G	EGFR_uc010kzg.1_Silent_p.G604G|EGFR_uc011kco.1_Silent_p.G596G	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	649	Helical; (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCGCCACTGGGATGGTGGGGG	0.632		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			5	222					0	0	0	0	A	55240703	A	A	55240703	2	1	23	1	0	0	0	0	0	0	0	1	4989	1161	41	2		2	EGFR	7	55240703	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	28071686	55240703	103897960	153	4768											
PION	54103	broad.mit.edu	37	chr7	77006225	77006225	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaagatactccttgatttCtaaaagagaaaacagaatgg	17	12	7	5	0	1	4	0	1	1	3	2	5	2	4	1	1	2	0	1	1	7	6	rs10268488		TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:77006225C>G	uc003ugf.2	-	10	761	c.682_splice	c.e10-1	p.K228_splice	PION_uc003ugg.1_Splice_Site_p.K13_splice	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog						beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						TCCTTGATTTCTAAAAGAGAA	0.308													7	136					0	0	0	0	G	77006225	G	G	77006225	5	3	23	1	0	0	0	0	0	0	1	0	11989	927	32	2	1971	2	PION	7	77006225	Splice_Site	SNP	C	TCGA-BB-4223-01A-01D-1434-08	21765522	77006225	82132438	154	4769											
AKAP9	10142	broad.mit.edu	37	chr7	91630469	91630469	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaatcataaagacagccAgttcgaaactgatatagtac	18	8	8	7	1	1	3	1	1	0	2	2	5	1	3	1	0	3	2	1	0	7	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:91630469A>G	uc003ulg.2	+	8	1463	c.1238A>G	c.(1237-1239)CAG>CGG	p.Q413R	AKAP9_uc003ule.2_Missense_Mutation_p.Q425R|AKAP9_uc003ulf.2_Missense_Mutation_p.Q413R|AKAP9_uc003uli.2_Missense_Mutation_p.Q38R	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	425	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAGACAGCCAGTTCGAAACT	0.323			T	BRAF	papillary thyroid								32	86					0	0	0	0	G	91630469	G	G	91630469	3	3	23	1	0	0	0	0	1	0	0	0	459	188	7	5	1268	5	AKAP9	7	91630469	Missense_Mutation	SNP	A	TCGA-BB-4223-01A-01D-1434-08	14624244	91630469	67508194	155	4770											
AKAP9	10142	broad.mit.edu	37	chr7	91726995	91726995	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatcaaactacgctaaattGattgaaatgaatggaggagg	17	9	11	4	1	1	3	1	3	0	0	1	6	1	5	0	3	2	1	0	3	7	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:91726995G>C	uc003ulg.2	+	42	10719	c.10494G>C	c.(10492-10494)TTG>TTC	p.L3498F	AKAP9_uc003ulf.2_Missense_Mutation_p.L3490F|AKAP9_uc003uli.2_Missense_Mutation_p.L3121F|AKAP9_uc003ulj.2_Missense_Mutation_p.L1268F|AKAP9_uc003ull.2_Missense_Mutation_p.L394F	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3502					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACGCTAAATTGATTGAAATGA	0.393			T	BRAF	papillary thyroid								5	166					0	0	0	0	C	91726995	C	C	91726995	3	2	23	1	0	0	0	0	1	0	0	0	459	1281	45	2	10660	2	AKAP9	7	91726995	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	96526	91726995	67411668	156	4771											
ZNF394	84124	broad.mit.edu	37	chr7	99091737	99091737	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaggtcagagcgttgtttGaaactcttcccacagttacc	11	11	9	10	1	2	3	1	1	1	2	3	3	3	3	2	1	3	3	2	1	3	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:99091737G>C	uc003uqs.2	-	3	1262	c.1101C>G	c.(1099-1101)TTC>TTG	p.F367L	ZNF394_uc003uqt.2_Missense_Mutation_p.F160L	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	367	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AGCGTTGTTTGAAACTCTTCC	0.483													7	269					0	0	0	0	C	99091737	C	C	99091737	3	2	23	1	0	0	0	0	1	0	0	0	17947	1281	45	2	588	2	ZNF394	7	99091737	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	7364742	99091737	60046926	157	4772											
ZAN	7455	broad.mit.edu	37	chr7	100365621	100365621	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctcctatggcggccagctCtgtgggctgtgtggtgagtt	3	13	15	10	1	1	1	0	1	1	0	3	1	3	1	3	4	1	3	3	4	1	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:100365621C>G	uc003uwj.2	+	26	5193	c.5028C>G	c.(5026-5028)CTC>CTG	p.L1676L	ZAN_uc003uwk.2_Silent_p.L1676L|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Silent_p.L253L	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1676	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCGGCCAGCTCTGTGGGCTGT	0.602													5	35					0	0	0	0	G	100365621	G	G	100365621	2	3	23	1	0	0	0	0	0	0	0	1	17581	900	32	2		2	ZAN	7	100365621	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1273884	100365621	58773042	158	4773											
TRIM56	81844	broad.mit.edu	37	chr7	100732101	100732101	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tttccccacgcggatgcctgGagacaagcggtccccccgga	7	6	12	16	4	0	1	0	0	0	1	2	4	2	3	6	4	2	0	6	4	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:100732101G>C	uc003uxq.2	+	3	1739	c.1508G>C	c.(1507-1509)GGA>GCA	p.G503A	TRIM56_uc003uxr.2_Intron	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	503					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					CGGATGCCTGGAGACAAGCGG	0.657													82	194					0	0	0	0	C	100732101	C	C	100732101	3	2	23	1	0	0	0	0	1	0	0	0	16597	1174	41	2	1510	2	TRIM56	7	100732101	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	366480	100732101	58406562	159	4774											
MLL5	55904	broad.mit.edu	37	chr7	104746007	104746007	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttagctacacaactcaattCtttaccaggtctcacttaca	12	13	4	12	0	3	0	2	0	2	0	4	0	3	0	1	1	5	2	1	1	6	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:104746007C>G	uc003vcm.2	+	18	2852	c.2318C>G	c.(2317-2319)TCT>TGT	p.S773C	MLL5_uc010ljc.2_Missense_Mutation_p.S773C|MLL5_uc010lje.1_RNA|MLL5_uc010ljf.1_5'Flank|MLL5_uc010ljg.2_5'Flank	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	773					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						CAACTCAATTCTTTACCAGGT	0.398													8	236					0	0	0	0	G	104746007	G	G	104746007	3	3	23	1	0	0	0	0	1	0	0	0	9677	913	32	2	2380	2	MLL5	7	104746007	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	4013906	104746007	54392656	160	4775											
NRCAM	4897	broad.mit.edu	37	chr7	107866759	107866759	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtcctctgggaggacattgGaaaaataaaggtccccattc	12	10	10	9	0	1	0	0	0	1	0	4	3	3	3	3	4	0	0	3	4	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:107866759G>T	uc003vfb.2	-	9	1085	c.614C>A	c.(613-615)TCC>TAC	p.S205Y	NRCAM_uc003vfc.2_Missense_Mutation_p.S199Y|NRCAM_uc011kmk.1_Missense_Mutation_p.S200Y|NRCAM_uc003vfd.2_Missense_Mutation_p.S200Y|NRCAM_uc003vfe.2_Missense_Mutation_p.S200Y	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	205	Ig-like 2.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						GAGGACATTGGAAAAATAAAG	0.413													8	279					2.17888e-05	2.23865e-05	1	0	T	107866759	T	T	107866759	3	4	23	1	0	0	0	0	1	0	0	0	10698	1174	41	2	3430	2	NRCAM	7	107866759	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3120752	107866759	51271904	161	4776											
NRCAM	4897	broad.mit.edu	37	chr7	107866787	107866787	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggtccccattcaaaccttGagaaactctctcactttgtg	11	12	6	12	0	3	1	2	1	1	1	5	2	4	1	3	1	2	0	3	1	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:107866787G>C	uc003vfb.2	-	9	1057	c.586C>G	c.(586-588)CAA>GAA	p.Q196E	NRCAM_uc003vfc.2_Missense_Mutation_p.Q190E|NRCAM_uc011kmk.1_Missense_Mutation_p.Q191E|NRCAM_uc003vfd.2_Missense_Mutation_p.Q191E|NRCAM_uc003vfe.2_Missense_Mutation_p.Q191E	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	196	Ig-like 2.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TTCAAACCTTGAGAAACTCTC	0.403													6	252					0	0	0	0	C	107866787	C	C	107866787	3	2	23	1	0	0	0	0	1	0	0	0	10698	1299	45	2	3458	2	NRCAM	7	107866787	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	28	107866787	51271876	162	4777											
DOCK4	9732	broad.mit.edu	37	chr7	111368537	111368537	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgctgtacgggggcggagtCttgctctccttgcgcactgg	4	10	15	12	4	2	0	0	0	2	0	3	1	2	1	1	4	3	4	1	4	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:111368537C>G	uc003vfx.2	-	52	5963	c.5694G>C	c.(5692-5694)AAG>AAC	p.K1898N	DOCK4_uc011kml.1_Missense_Mutation_p.K779N|DOCK4_uc011kmm.1_Missense_Mutation_p.K767N|DOCK4_uc003vfw.2_Missense_Mutation_p.K1310N|DOCK4_uc003vfy.2_Missense_Mutation_p.K1943N|DOCK4_uc003vfv.2_Missense_Mutation_p.K211N	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1898	Pro-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				GGGGCGGAGTCTTGCTCTCCT	0.692													4	71					0	0	0	0	G	111368537	G	G	111368537	3	3	23	1	0	0	0	0	1	0	0	0	4711	912	32	2	210	2	DOCK4	7	111368537	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	3501750	111368537	47770126	163	4778											
FAM40B	57464	broad.mit.edu	37	chr7	129122805	129122805	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aagtacctggggcgccaatgGaggaaaagcaacatgaaaac	17	4	12	8	1	0	1	0	1	0	0	0	3	0	3	2	4	4	2	2	4	8	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:129122805G>C	uc011koy.1	+	20	2212	c.2172G>C	c.(2170-2172)TGG>TGC	p.W724C	FAM40B_uc003vow.2_Missense_Mutation_p.W724C|FAM40B_uc011koz.1_Missense_Mutation_p.W216C	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	724											0						GGCGCCAATGGAGGAAAAGCA	0.488													7	107					0	0	0	0	C	129122805	C	C	129122805	3	2	23	1	0	0	0	0	1	0	0	0	5593	1183	41	2	2250	2	FAM40B	7	129122805	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	17754268	129122805	30015858	164	4779											
DGKI	9162	broad.mit.edu	37	chr7	137363312	137363312	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcacactcactgcaaatctGacttggcagttctcctctcc	8	11	6	16	1	4	1	1	1	3	0	6	1	4	1	2	1	1	4	2	1	1	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:137363312G>C	uc003vtt.2	-	3	598	c.597C>G	c.(595-597)GTC>GTG	p.V199V	DGKI_uc003vtu.2_5'UTR	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	199	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CTGCAAATCTGACTTGGCAGT	0.532													23	473					0	0	0	0	C	137363312	C	C	137363312	2	2	23	1	0	0	0	0	0	0	0	1	4493	1277	45	2		2	DGKI	7	137363312	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	8240507	137363312	21775351	165	4780											
JHDM1D	80853	broad.mit.edu	37	chr7	139827294	139827294	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taacacttttggtctgttagGattcatgaagtatttaacat	12	17	7	5	0	2	1	1	1	1	0	2	2	2	2	0	2	2	2	0	2	5	8			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:139827294G>A	uc003vvm.2	-	5	653	c.649C>T	c.(649-651)CCT>TCT	p.P217S		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	217					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					GGTCTGTTAGGATTCATGAAG	0.378													11	227					0	0	0	0	A	139827294	A	A	139827294	3	1	23	1	0	0	0	0	1	0	0	0	7987	1174	41	2	2240	2	JHDM1D	7	139827294	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2463982	139827294	19311369	166	4781											
BRAF	673	broad.mit.edu	37	chr7	140434447	140434447	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgcctggatgggtgtttttgGagaagcacaagcatatagac	11	11	13	6	0	0	2	0	0	0	2	0	4	0	3	1	3	3	3	1	3	4	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:140434447G>C	uc003vwc.3	-	18	2312	c.2251C>G	c.(2251-2253)CCA>GCA	p.P751A		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	751					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	GGTGTTTTTGGAGAAGCACAA	0.463		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				28	609					0	0	0	0	C	140434447	C	C	140434447	3	2	23	1	0	0	0	0	1	0	0	0	1501	1174	41	2	53	2	BRAF	7	140434447	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	607153	140434447	18704216	167	4782											
PDIA4	9601	broad.mit.edu	37	chr7	148702240	148702240	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccacgggctcaccttttttGaaagcagtgacaaactcgcg	10	9	10	12	3	1	2	1	2	0	0	2	2	1	2	2	1	2	2	2	1	2	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr7:148702240G>A	uc003wff.2	-	9	1797	c.1515C>T	c.(1513-1515)TTC>TTT	p.F505F		NM_004911	NP_004902	P13667	PDIA4_HUMAN	protein disulfide isomerase A4 precursor	505	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			lung(5)|ovary(1)	6	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			CACCTTTTTTGAAAGCAGTGA	0.602													12	328					0	0	0	0	A	148702240	A	A	148702240	2	1	23	1	0	0	0	0	0	0	0	1	11724	1281	45	2		2	PDIA4	7	148702240	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	8267793	148702240	10436423	168	4783											
CSGALNACT1	55790	broad.mit.edu	37	chr8	19316071	19316071	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgaatggtcgaaataagatGagccgtttgaattcgtgttt	11	13	11	6	4	0	3	0	2	0	1	2	5	0	3	2	1	1	2	2	1	4	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr8:19316071G>A	uc011kyn.1	-	5	1781	c.717C>T	c.(715-717)CTC>CTT	p.L239L	CSGALNACT1_uc011kyo.1_Silent_p.L239L|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Silent_p.L238L|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	239	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		GAAATAAGATGAGCCGTTTGA	0.433													20	529					0	0	0	0	A	19316071	A	A	19316071	2	1	23	1	0	0	0	0	0	0	0	1	3955	1277	45	2		2	CSGALNACT1	8	19316071	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08		19316071	127047951	169	4784											
PDLIM2	64236	broad.mit.edu	37	chr8	22438988	22438988	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cggagggcatgctgcatgccGaggcccagagcaagatccgc	9	4	15	13	3	0	2	0	0	0	2	1	4	1	3	3	3	4	4	3	3	1	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr8:22438988G>C	uc003xby.2	+	3	590	c.190G>C	c.(190-192)GAG>CAG	p.E64Q	PDLIM2_uc003xbx.1_Missense_Mutation_p.E64Q|PDLIM2_uc003xbz.2_Missense_Mutation_p.E64Q|PDLIM2_uc003xca.2_Missense_Mutation_p.E64Q|PDLIM2_uc003xcb.2_Missense_Mutation_p.E64Q|PDLIM2_uc003xcc.1_Missense_Mutation_p.E64Q	NM_021630	NP_067643	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 isoform 2	64	PDZ.					actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		GCTGCATGCCGAGGCCCAGAG	0.682													3	60					0	0	0	0	C	22438988	C	C	22438988	3	2	23	1	0	0	0	0	1	0	0	0	11734	1059	37	3	196	3	PDLIM2	8	22438988	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3122917	22438988	123925034	170	4785											
TACC1	6867	broad.mit.edu	37	chr8	38677342	38677342	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgccagacgccctccaggacGaggcgatgacagaaggcagc	11	2	14	14	4	0	3	0	1	0	2	1	6	1	4	3	3	1	1	3	3	1	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr8:38677342G>A	uc010lwp.2	+	3	959	c.580G>A	c.(580-582)GAG>AAG	p.E194K	TACC1_uc011lby.1_5'UTR|TACC1_uc003xma.2_Intron|TACC1_uc003xlz.2_5'UTR|TACC1_uc003xmc.3_5'UTR|TACC1_uc011lbz.1_Missense_Mutation_p.E210K|TACC1_uc003xmb.3_Missense_Mutation_p.E149K|TACC1_uc003xme.1_Intron|TACC1_uc003xmd.1_Intron|TACC1_uc010lwo.1_Intron|TACC1_uc003xmf.3_Intron|TACC1_uc011lca.1_Missense_Mutation_p.E194K|TACC1_uc011lcb.1_5'UTR|TACC1_uc011lcc.1_5'UTR|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_5'UTR|TACC1_uc010lwq.2_5'UTR	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	194	Interaction with TDRD7.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			CCTCCAGGACGAGGCGATGAC	0.597													8	257					0	0	0	0	A	38677342	A	A	38677342	3	1	23	1	0	0	0	0	1	0	0	0	15567	1059	37	1	590	1	TACC1	8	38677342	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	16238354	38677342	107686680	171	4786											
HOOK3	84376	broad.mit.edu	37	chr8	42823326	42823326	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttaagaaaggccaacgcagCgcgaagtcaacttgaaacct	15	6	10	10	3	1	2	1	1	0	1	1	3	1	2	2	1	4	2	2	1	6	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr8:42823326C>T	uc003xpr.2	+	11	1333	c.1091C>T	c.(1090-1092)GCG>GTG	p.A364V	HOOK3_uc010lxq.1_Missense_Mutation_p.A364V	NM_032410	NP_115786	Q86VS8	HOOK3_HUMAN	golgi-associated microtubule-binding protein	364	Potential.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			ovary(1)|breast(1)	2	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			GCCAACGCAGCGCGAAGTCAA	0.418			T	RET	papillary thyroid								4	72					0	0	0	0	T	42823326	T	T	42823326	3	4	23	1	0	0	0	0	1	0	0	0	7323	768	27	1	1133	1	HOOK3	8	42823326	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	4145984	42823326	103540696	172	4787											
ST18	9705	broad.mit.edu	37	chr8	53079543	53079543	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctcttttcaggccttggtGaatctatggagaaattcaat	10	14	8	9	0	4	2	2	1	2	1	4	3	4	2	2	3	0	0	2	3	4	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr8:53079543G>A	uc003xqz.2	-	6	1229	c.1073C>T	c.(1072-1074)TCA>TTA	p.S358L	ST18_uc011ldq.1_Missense_Mutation_p.S5L|ST18_uc011ldr.1_Missense_Mutation_p.S323L|ST18_uc011lds.1_Missense_Mutation_p.S263L|ST18_uc003xra.2_Missense_Mutation_p.S358L|ST18_uc003xrb.2_Missense_Mutation_p.S358L	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	358						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AGGCCTTGGTGAATCTATGGA	0.493													158	177					0	0	0	0	A	53079543	A	A	53079543	3	1	23	1	0	0	0	0	1	0	0	0	15278	1294	45	2	2134	2	ST18	8	53079543	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	10256217	53079543	93284479	173	4788											
LY96	23643	broad.mit.edu	37	chr8	74922333	74922333	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgccgaggatctgatgaCgattactctttttgcagagc	9	14	10	8	2	2	3	0	2	2	1	2	6	2	4	1	1	4	1	1	1	1	4	rs148048520	byFrequency	TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr8:74922333C>T	uc003yad.2	+	3	391	c.300C>T	c.(298-300)GAC>GAT	p.D100D		NM_015364	NP_056179	Q9Y6Y9	LY96_HUMAN	MD-2 protein precursor	100					cellular defense response|detection of lipopolysaccharide|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	extracellular space|lipopolysaccharide receptor complex|plasma membrane	coreceptor activity|lipopolysaccharide receptor activity|protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0208)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0619)			GATCTGATGACGATTACTCTT	0.313													92	90					0	0	0	0	T	74922333	T	T	74922333	2	4	23	1	0	0	0	0	0	0	0	1	9153	535	19	1		1	LY96	8	74922333	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	21842790	74922333	71441689	174	4789											
ZNF704	619279	broad.mit.edu	37	chr8	81733769	81733769	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccaaggaaaacacgtgttGatgagacatttttttaccac	13	11	9	8	1	0	2	0	2	0	1	0	4	0	3	2	2	2	1	2	2	4	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr8:81733769G>C	uc003yby.1	-	2	293	c.61C>G	c.(61-63)CAA>GAA	p.Q21E		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	21						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			AACACGTGTTGATGAGACATT	0.438													23	783					0	0	0	0	C	81733769	C	C	81733769	3	2	23	1	0	0	0	0	1	0	0	0	18174	1299	45	2	1209	2	ZNF704	8	81733769	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	6811436	81733769	64630253	175	4790											
PDP1	54704	broad.mit.edu	37	chr8	94934633	94934633	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccttggatttgacagcaatCagctgcctgcaaatgcaccc	10	10	8	13	0	1	1	1	1	0	0	2	2	2	2	3	1	5	4	3	1	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr8:94934633C>T	uc003yge.2	+	2	615	c.346C>T	c.(346-348)CAG>TAG	p.Q116*	PDP1_uc003ygf.2_Nonsense_Mutation_p.Q141*|PDP1_uc010max.2_Nonsense_Mutation_p.Q141*|PDP1_uc011lgm.1_Nonsense_Mutation_p.Q116*|PDP1_uc011lgn.1_Nonsense_Mutation_p.Q175*	NM_018444	NP_060914	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic	116				NVSSILGFDSNQ -> MSVLSLDLTAIK (in Ref. 1; AAF67480).	pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						TGACAGCAATCAGCTGCCTGC	0.463													11	318					0	0	0	0	T	94934633	T	T	94934633	4	4	23	1	0	0	0	0	0	1	0	0	11739	827	29	2	529	2	PDP1	8	94934633	Nonsense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	13200864	94934633	51429389	176	4791											
ATAD2	29028	broad.mit.edu	37	chr8	124358863	124358863	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaagaaaaatatacctattCaaatgaagaaaattaaaatt	23	10	4	4	0	1	3	1	1	0	2	1	3	1	3	1	0	1	1	1	0	12	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr8:124358863C>G	uc003yqh.3	-	17	2448	c.2340G>C	c.(2338-2340)TTG>TTC	p.L780F	ATAD2_uc011lii.1_Missense_Mutation_p.L571F|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.L780F	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	780					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TATACCTATTCAAATGAAGAA	0.279													3	91					0	0	0	0	G	124358863	G	G	124358863	3	3	23	1	0	0	0	0	1	0	0	0	1073	825	29	2	1880	2	ATAD2	8	124358863	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	29424230	124358863	22005159	177	4792											
SLC45A4	57210	broad.mit.edu	37	chr8	142228605	142228605	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgggactttagcttcattCaagtgattatccagcaaggt	10	15	9	7	0	2	1	2	1	0	0	3	2	3	2	1	2	2	2	1	2	4	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr8:142228605C>G	uc003ywd.1	-	4	1289	c.981G>C	c.(979-981)TTG>TTC	p.L327F	SLC45A4_uc003ywc.1_Missense_Mutation_p.L327F|SLC45A4_uc010meq.1_Missense_Mutation_p.L325F	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	378					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TAGCTTCATTCAAGTGATTAT	0.617													4	175					0	0	0	0	G	142228605	G	G	142228605	3	3	23	1	0	0	0	0	1	0	0	0	14707	825	29	2	1435	2	SLC45A4	8	142228605	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	17869742	142228605	4135417	178	4793											
KIAA2026	158358	broad.mit.edu	37	chr9	5920395	5920395	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgaatacaaggttcactGaactgactcccgactagact	12	10	8	11	1	1	4	1	3	0	1	2	5	2	4	1	1	3	2	1	1	5	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:5920395G>A	uc003zjq.3	-	8	5817	c.5601C>T	c.(5599-5601)TTC>TTT	p.F1867F	KIAA2026_uc010mht.2_Silent_p.F1042F	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1867										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AAGGTTCACTGAACTGACTCC	0.448													13	345					0	0	0	0	A	5920395	A	A	5920395	2	1	23	1	0	0	0	0	0	0	0	1	8309	1281	45	2		2	KIAA2026	9	5920395	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08		5920395	135293036	179	4794											
BNC2	54796	broad.mit.edu	37	chr9	16435892	16435892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttgatgacgtcctggtgaGagggctcactgtggttctca	6	12	13	10	1	2	3	2	3	1	1	4	4	3	3	2	3	0	2	2	3	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:16435892G>A	uc003zml.2	-	6	2440	c.2300C>T	c.(2299-2301)TCT>TTT	p.S767F	BNC2_uc011lmw.1_Missense_Mutation_p.S672F|BNC2_uc003zmm.2_Missense_Mutation_p.S725F|BNC2_uc003zmq.1_Missense_Mutation_p.S781F|BNC2_uc003zmr.1_Missense_Mutation_p.S804F|BNC2_uc003zmp.1_Missense_Mutation_p.S795F|BNC2_uc010mij.1_Missense_Mutation_p.S689F|BNC2_uc011lmv.1_Missense_Mutation_p.S593F|BNC2_uc003zmo.1_Missense_Mutation_p.S689F|BNC2_uc003zmj.2_Missense_Mutation_p.S532F|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.S532F|BNC2_uc003zmn.1_Missense_Mutation_p.S532F	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	767					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GTCCTGGTGAGAGGGCTCACT	0.502													4	99					0	0	0	0	A	16435892	A	A	16435892	3	1	23	1	0	0	0	0	1	0	0	0	1478	942	33	2	1007	2	BNC2	9	16435892	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	10515497	16435892	124777539	180	4795											
DENND4C	55667	broad.mit.edu	37	chr9	19316773	19316773	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaggatatagaacatatctCagaccaatcacagaggctcc	17	7	7	10	0	2	3	2	0	1	3	4	4	3	4	2	2	1	1	2	2	6	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:19316773C>G	uc003znq.2	+	8	1068	c.1035C>G	c.(1033-1035)CTC>CTG	p.L345L	DENND4C_uc011lnc.1_5'UTR	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	345	dDENN.					integral to membrane				ovary(1)|skin(1)	2						GAACATATCTCAGACCAATCA	0.393													6	314					0	0	0	0	G	19316773	G	G	19316773	2	3	23	1	0	0	0	0	0	0	0	1	4457	813	29	2		2	DENND4C	9	19316773	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2880881	19316773	121896658	181	4796											
KIAA1797	54914	broad.mit.edu	37	chr9	20820388	20820388	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaccacgactaagagctgtCactttgcgcttgctgacatc	10	10	8	13	2	1	2	1	1	0	1	2	3	1	2	1	0	3	3	1	0	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:20820388C>G	uc003zog.1	+	15	1989	c.1626C>G	c.(1624-1626)GTC>GTG	p.V542V	KIAA1797_uc003zoh.1_5'UTR	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	542						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		TAAGAGCTGTCACTTTGCGCT	0.353													4	175					0	0	0	0	G	20820388	G	G	20820388	2	3	23	1	0	0	0	0	0	0	0	1	8297	813	29	2		2	KIAA1797	9	20820388	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1503615	20820388	120393043	182	4797											
IFNE	338376	broad.mit.edu	37	chr9	21481364	21481364	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgttgatgaagttgaatGaggaatttctccgtgtggtt	9	15	13	4	1	1	4	0	4	1	0	2	5	1	5	1	2	1	4	1	2	3	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:21481364G>A	uc003zpg.2	-	1	949	c.330C>T	c.(328-330)CTC>CTT	p.L110L	LOC554202_uc003zpe.2_Intron|LOC554202_uc003zpf.2_Intron	NM_176891	NP_795372	Q86WN2	IFNE_HUMAN	interferon, epsilon precursor	110					defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding				0						GAAGTTGAATGAGGAATTTCT	0.448													11	265					0	0	0	0	A	21481364	A	A	21481364	2	1	23	1	0	0	0	0	0	0	0	1	7586	1277	45	2		2	IFNE	9	21481364	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	660976	21481364	119732067	183	4798											
IFNE	338376	broad.mit.edu	37	chr9	21481504	21481504	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaggactcaaagacttctGaggaagcagaaagtttttcc	13	10	10	8	0	2	4	1	2	1	2	3	6	3	6	1	2	1	2	1	2	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:21481504G>C	uc003zpg.2	-	1	809	c.190C>G	c.(190-192)CAG>GAG	p.Q64E	LOC554202_uc003zpe.2_Intron|LOC554202_uc003zpf.2_Intron	NM_176891	NP_795372	Q86WN2	IFNE_HUMAN	interferon, epsilon precursor	64					defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding				0						AAAGACTTCTGAGGAAGCAGA	0.418													3	118					0	0	0	0	C	21481504	C	C	21481504	3	2	23	1	0	0	0	0	1	0	0	0	7586	1299	45	2	440	2	IFNE	9	21481504	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	140	21481504	119731927	184	4799											
RGP1	9827	broad.mit.edu	37	chr9	35751361	35751361	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaagattcatggctagctGagctggctggggaacgccta	11	8	14	8	1	1	3	1	1	0	2	1	4	1	4	1	4	3	4	1	4	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:35751361G>C	uc011lpf.1	+	6	727	c.586G>C	c.(586-588)GAG>CAG	p.E196Q	GBA2_uc011lpb.1_5'Flank|GBA2_uc003zxw.2_5'Flank|GBA2_uc011lpc.1_5'Flank|GBA2_uc011lpd.1_5'Flank|RGP1_uc011lpe.1_Missense_Mutation_p.E236Q	NM_001080496	NP_001073965	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog	196										ovary(1)	1	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ATGGCTAGCTGAGCTGGCTGG	0.547													5	139					0	0	0	0	C	35751361	C	C	35751361	3	2	23	1	0	0	0	0	1	0	0	0	13349	1291	45	2	732	2	RGP1	9	35751361	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	14269857	35751361	105462070	185	4800											
NPR2	4882	broad.mit.edu	37	chr9	35807370	35807370	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtatacctgctttgatgccaTaattgacaactttgatgtct	10	16	7	8	0	1	3	0	3	1	0	1	3	1	3	2	0	4	2	2	0	4	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:35807370T>C	uc003zyd.2	+	18	2687	c.2687T>C	c.(2686-2688)ATA>ACA	p.I896T	NPR2_uc010mlb.2_Missense_Mutation_p.I872T	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	896	Guanylate cyclase.|Cytoplasmic (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	TTTGATGCCATAATTGACAAC	0.443													40	313					0	0	0	0	C	35807370	C	C	35807370	3	2	23	1	0	0	0	0	1	0	0	0	10649	1406	49	5	2757	5	NPR2	9	35807370	Missense_Mutation	SNP	T	TCGA-BB-4223-01A-01D-1434-08	56009	35807370	105406061	186	4801											
ZNF658	26149	broad.mit.edu	37	chr9	40772638	40772638	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcattacattcatagggtttCtcccctgtgtgaattctgtg	7	17	8	9	0	4	1	2	1	2	0	5	1	4	1	2	1	1	1	2	1	3	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:40772638C>G	uc004abs.2	-	5	2789	c.2637G>C	c.(2635-2637)GAG>GAC	p.E879D	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.E879D	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	879					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CATAGGGTTTCTCCCCTGTGT	0.443													12	226					0	0	0	0	G	40772638	G	G	40772638	3	3	23	1	0	0	0	0	1	0	0	0	18136	912	32	2	546	2	ZNF658	9	40772638	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	4965268	40772638	100440793	187	4802											
NTRK2	4915	broad.mit.edu	37	chr9	87325654	87325654	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcaggatttgtactgcctGaatgaaagcagcaagaatat	15	10	9	7	0	1	3	1	2	0	1	1	4	1	4	1	1	4	3	1	1	6	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:87325654G>A	uc004aoa.1	+	8	1469	c.531G>A	c.(529-531)CTG>CTA	p.L177L	NTRK2_uc004anv.1_Silent_p.L177L|NTRK2_uc004any.1_Silent_p.L177L|NTRK2_uc004anz.1_Silent_p.L177L|NTRK2_uc011lsz.1_Silent_p.L177L|NTRK2_uc011lta.1_Silent_p.L177L|NTRK2_uc004aob.1_Silent_p.L177L|NTRK2_uc011ltb.1_Silent_p.L21L	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	177	Extracellular (Potential).|LRRCT.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						TGTACTGCCTGAATGAAAGCA	0.403										TSP Lung(25;0.17)			5	124					0	0	0	0	A	87325654	A	A	87325654	2	1	23	1	0	0	0	0	0	0	0	1	10761	1277	45	2		2	NTRK2	9	87325654	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	46553016	87325654	53887777	188	4803											
C9orf79	286234	broad.mit.edu	37	chr9	90500184	90500184	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctctccacctccacccgactCcagcctggctggacttcagt	6	9	7	19	1	2	0	1	0	1	0	5	2	4	1	6	2	1	1	6	2	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:90500184C>T	uc004app.3	+	4	817	c.782C>T	c.(781-783)TCC>TTC	p.S261F	C9orf79_uc004apo.1_Missense_Mutation_p.S73F	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	261	Pro-rich.					integral to membrane				ovary(3)	3						CCACCCGACTCCAGCCTGGCT	0.607													9	141					0	0	0	0	T	90500184	T	T	90500184	3	4	23	1	0	0	0	0	1	0	0	0	2509	855	30	2	796	2	C9orf79	9	90500184	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	3174530	90500184	50713247	189	4804											
ZNF169	169841	broad.mit.edu	37	chr9	97062673	97062673	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tagccagaaggcctccctctCcatacaccagaggaagcact	12	6	8	15	0	1	2	0	0	1	2	3	3	2	3	5	2	3	1	5	2	4	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:97062673C>G	uc004aum.1	+	5	938	c.833C>G	c.(832-834)TCC>TGC	p.S278C		NM_194320	NP_919301	Q14929	ZN169_HUMAN	zinc finger protein 169	278	C2H2-type 2.			SLS -> PSP (in Ref. 5; AAA70188).		nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				GCCTCCCTCTCCATACACCAG	0.542													4	172					0	0	0	0	G	97062673	G	G	97062673	3	3	23	1	0	0	0	0	1	0	0	0	17809	855	30	2	847	2	ZNF169	9	97062673	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	6562489	97062673	44150758	190	4805											
SVEP1	79987	broad.mit.edu	37	chr9	113275356	113275356	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttggataaagtaaccattttCgggaggcttcagggcagggc	10	10	14	7	1	1	0	1	0	0	0	2	2	1	2	1	5	1	3	1	5	3	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:113275356C>T	uc010mtz.2	-	5	1490	c.1153G>A	c.(1153-1155)GAA>AAA	p.E385K	SVEP1_uc010mua.1_Missense_Mutation_p.E385K|SVEP1_uc004beu.2_Missense_Mutation_p.E385K|SVEP1_uc004bev.2_Missense_Mutation_p.E129K	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	385	Sushi 1.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TAACCATTTTCGGGAGGCTTC	0.403													14	62					0	0	0	0	T	113275356	T	T	113275356	3	4	23	1	0	0	0	0	1	0	0	0	15486	893	31	1	9738	1	SVEP1	9	113275356	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	16212683	113275356	27938075	191	4806											
PIP5KL1	138429	broad.mit.edu	37	chr9	130687445	130687445	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcatcctcgtggagacgttgGaaggctatcaggaggctgta	9	10	14	8	2	2	1	2	0	0	1	4	4	3	3	1	5	0	4	1	5	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:130687445G>A	uc011mao.1	-	9	903	c.858C>T	c.(856-858)TTC>TTT	p.F286F	PIP5KL1_uc004bsu.2_Silent_p.F83F	NM_001135219	NP_001128691	Q5T9C9	PI5L1_HUMAN	phosphatidylinositol-4-phosphate 5-kinase-like 1	286	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			lung(1)|kidney(1)	2						GGAGACGTTGGAAGGCTATCA	0.637													10	181					0	0	0	0	A	130687445	A	A	130687445	2	1	23	1	0	0	0	0	0	0	0	1	11997	1165	41	2		2	PIP5KL1	9	130687445	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	17412089	130687445	10525986	192	4807											
PIP5KL1	138429	broad.mit.edu	37	chr9	130687478	130687478	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggctgtaatccagcacgttGagctcccggaggaaggtggt	9	8	15	9	2	0	1	0	1	0	0	2	3	2	3	2	5	2	5	2	5	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:130687478G>C	uc011mao.1	-	9	870	c.825C>G	c.(823-825)CTC>CTG	p.L275L	PIP5KL1_uc004bsu.2_Silent_p.L72L	NM_001135219	NP_001128691	Q5T9C9	PI5L1_HUMAN	phosphatidylinositol-4-phosphate 5-kinase-like 1	275	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			lung(1)|kidney(1)	2						CCAGCACGTTGAGCTCCCGGA	0.602													5	142					0	0	0	0	C	130687478	C	C	130687478	2	2	23	1	0	0	0	0	0	0	0	1	11997	1277	45	2		2	PIP5KL1	9	130687478	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	33	130687478	10525953	193	4808											
PRDM12	59335	broad.mit.edu	37	chr9	133542052	133542052	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggtgatcatcgctcagagctCcatccctggcgagggcctcg	6	8	13	14	3	2	2	2	1	0	1	6	3	4	2	3	3	1	2	3	3	0	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:133542052C>G	uc004bzt.1	+	2	341	c.281C>G	c.(280-282)TCC>TGC	p.S94C		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	94	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GCTCAGAGCTCCATCCCTGGC	0.672													6	197					0	0	0	0	G	133542052	G	G	133542052	3	3	23	1	0	0	0	0	1	0	0	0	12515	855	30	2	287	2	PRDM12	9	133542052	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2854574	133542052	7671379	194	4809											
C9orf171	389799	broad.mit.edu	37	chr9	135357756	135357756	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgactcctcagcggtgcaGaaagttattccttcccttgc	8	13	8	12	1	1	2	1	1	0	1	4	2	4	2	3	1	3	2	3	1	3	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr9:135357756G>A	uc004cbn.2	+	2	303	c.255G>A	c.(253-255)CAG>CAA	p.Q85Q	C9orf171_uc004cbo.2_Intron	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	85										ovary(4)|large_intestine(1)	5						CAGCGGTGCAGAAAGTTATTC	0.493													10	172					0	0	0	0	A	135357756	A	A	135357756	2	1	23	1	0	0	0	0	0	0	0	1	2482	933	33	2		2	C9orf171	9	135357756	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1815704	135357756	5855675	195	4810											
KIAA1462	57608	broad.mit.edu	37	chr10	30316406	30316406	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacatcctcggctgtggctCaaccctcatttccgggctgt	5	11	9	16	2	2	0	2	0	0	0	5	0	4	0	4	3	1	3	4	3	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr10:30316406C>G	uc001iux.2	-	2	2730	c.2671G>C	c.(2671-2673)GAG>CAG	p.E891Q	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.E753Q|KIAA1462_uc009xle.1_Missense_Mutation_p.E891Q	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	891										ovary(4)	4						GGCTGTGGCTCAACCCTCATT	0.602													4	166					0	0	0	0	G	30316406	G	G	30316406	3	3	23	1	0	0	0	0	1	0	0	0	8273	835	29	2	1416	2	KIAA1462	10	30316406	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08		30316406	105218341	196	4811											
MAP3K8	1326	broad.mit.edu	37	chr10	30749691	30749691	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctcaagaggcaacgctctCtctacatcgacctcggcgct	8	9	9	15	4	3	1	1	0	2	1	6	2	3	1	1	2	3	4	1	2	3	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr10:30749691C>G	uc001ivi.1	+	9	2026	c.1330C>G	c.(1330-1332)CTC>GTC	p.L444V	MAP3K8_uc009xlf.1_Missense_Mutation_p.L444V|MAP3K8_uc001ivj.1_Missense_Mutation_p.L444V	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	444			Missing (in oncogenic form).		cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)				GCAACGCTCTCTCTACATCGA	0.463													7	180					0	0	0	0	G	30749691	G	G	30749691	3	3	23	1	0	0	0	0	1	0	0	0	9309	913	32	2	1356	2	MAP3K8	10	30749691	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	433285	30749691	104785056	197	4812											
ITGB1	3688	broad.mit.edu	37	chr10	33200866	33200866	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgaaattatcacactcgcaGaatttgccagaataaatttc	15	13	5	8	1	1	3	1	1	0	2	3	3	1	3	1	0	1	1	1	0	6	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr10:33200866G>A	uc001iws.3	-	12	1792	c.1656C>T	c.(1654-1656)TTC>TTT	p.F552F	ITGB1_uc001iwp.3_Silent_p.F552F|ITGB1_uc001iwq.3_Silent_p.F552F|ITGB1_uc001iwr.3_Silent_p.F552F|ITGB1_uc001iwt.3_Silent_p.F552F|ITGB1_uc001iwu.1_Silent_p.F552F	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	552	Extracellular (Potential).|Cysteine-rich tandem repeats.|II.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				CACACTCGCAGAATTTGCCAG	0.398													14	262					0	0	0	0	A	33200866	A	A	33200866	2	1	23	1	0	0	0	0	0	0	0	1	7929	933	33	2		2	ITGB1	10	33200866	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2451175	33200866	102333881	198	4813											
POLR3A	11128	broad.mit.edu	37	chr10	79737257	79737257	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tatgtgacaagggggatgtgGaattcatttgtgtcgaagat	11	13	14	3	1	1	2	1	1	0	1	2	5	1	4	0	3	0	0	0	3	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr10:79737257G>C	uc001jzn.2	-	31	4246	c.4152C>G	c.(4150-4152)TTC>TTG	p.F1384L		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	1384					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GGGGGATGTGGAATTCATTTG	0.517													11	207					0	0	0	0	C	79737257	C	C	79737257	3	2	23	1	0	0	0	0	1	0	0	0	12283	1165	41	2	24	2	POLR3A	10	79737257	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	46536391	79737257	55797490	199	4814											
POLR3A	11128	broad.mit.edu	37	chr10	79737319	79737319	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgggtccctgtcagccttgtGaagcagcttgaagagcccgg	7	8	14	12	2	1	3	1	2	0	1	2	3	2	3	3	2	4	2	3	2	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr10:79737319G>A	uc001jzn.2	-	31	4184	c.4090C>T	c.(4090-4092)CAC>TAC	p.H1364Y		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	1364					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			TCAGCCTTGTGAAGCAGCTTG	0.512													9	175					0	0	0	0	A	79737319	A	A	79737319	3	1	23	1	0	0	0	0	1	0	0	0	12283	1290	45	2	86	2	POLR3A	10	79737319	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	62	79737319	55797428	200	4815											
PNLIP	5406	broad.mit.edu	37	chr10	118306823	118306823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggaaaagaagtttgctacGaaagactcggctgcttcagt	13	9	11	8	2	1	2	1	0	0	2	2	4	1	3	0	2	3	4	0	2	5	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr10:118306823G>A	uc001lcm.2	+	3	107	c.64G>A	c.(64-66)GAA>AAA	p.E22K		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	22					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	AGTTTGCTACGAAAGACTCGG	0.423													6	141					0	0	0	0	A	118306823	A	A	118306823	3	1	23	1	0	0	0	0	1	0	0	0	12204	1059	37	1	70	1	PNLIP	10	118306823	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	38569504	118306823	17227924	201	4816											
TACC2	10579	broad.mit.edu	37	chr10	124001494	124001494	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaatagtggccgagtatgaGaagaccatcgctcagatgat	15	8	11	7	2	1	4	1	2	0	3	2	6	1	4	2	1	0	2	2	1	5	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr10:124001494G>C	uc001lfv.2	+	19	8730	c.8370G>C	c.(8368-8370)GAG>GAC	p.E2790D	TACC2_uc001lfw.2_Missense_Mutation_p.E936D|TACC2_uc009xzx.2_Missense_Mutation_p.E2668D|TACC2_uc010qtv.1_Missense_Mutation_p.E2717D|TACC2_uc001lfx.2_Missense_Mutation_p.E417D|TACC2_uc001lfy.2_Missense_Mutation_p.E413D|TACC2_uc001lfz.2_Missense_Mutation_p.E868D|TACC2_uc001lga.2_Missense_Mutation_p.E838D|TACC2_uc009xzy.2_Missense_Mutation_p.E850D|TACC2_uc001lgb.2_Missense_Mutation_p.E748D	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2790	Potential.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCGAGTATGAGAAGACCATCG	0.522													9	184					0	0	0	0	C	124001494	C	C	124001494	3	2	23	1	0	0	0	0	1	0	0	0	15568	933	33	2	8512	2	TACC2	10	124001494	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	5694671	124001494	11533253	202	4817											
CPXM2	119587	broad.mit.edu	37	chr10	125516751	125516751	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctccatgaacacgatcagaGattcccggttattctcccac	10	10	7	14	2	2	2	1	1	1	1	5	4	4	2	3	1	1	2	3	1	2	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr10:125516751G>A	uc001lhk.1	-	12	2220	c.1895C>T	c.(1894-1896)TCT>TTT	p.S632F	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	632					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CACGATCAGAGATTCCCGGTT	0.537													7	198					0	0	0	0	A	125516751	A	A	125516751	3	1	23	1	0	0	0	0	1	0	0	0	3853	942	33	2	387	2	CPXM2	10	125516751	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1515257	125516751	10017996	203	4818											
TUBGCP2	10844	broad.mit.edu	37	chr10	135096618	135096618	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacatgacgcacacagacatGagcttggagaagaccttcag	15	6	10	10	1	1	5	1	2	0	3	1	6	1	5	1	1	2	2	1	1	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr10:135096618G>A	uc001lmg.1	-	15	2610	c.2253C>T	c.(2251-2253)CTC>CTT	p.L751L	TUBGCP2_uc001lmf.1_Silent_p.L344L|TUBGCP2_uc010qvc.1_Silent_p.L779L|TUBGCP2_uc009ybk.1_Silent_p.L774L|TUBGCP2_uc010qvd.1_Silent_p.L621L|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	751					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		ACACAGACATGAGCTTGGAGA	0.612													7	123					0	0	0	0	A	135096618	A	A	135096618	2	1	23	1	0	0	0	0	0	0	0	1	16834	1277	45	2		2	TUBGCP2	10	135096618	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	9579867	135096618	438129	204	4819											
CDHR5	53841	broad.mit.edu	37	chr11	621851	621851	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggtcttaaaggggaattcGggggcattgtcattgacgtc	8	13	14	6	2	2	1	1	1	1	0	4	2	2	2	0	5	0	1	0	5	3	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:621851G>A	uc001lqj.2	-	4	471	c.366C>T	c.(364-366)CCC>CCT	p.P122P	CDHR5_uc001lqk.2_Silent_p.P122P|CDHR5_uc009ycc.2_5'UTR|CDHR5_uc009ycd.2_Silent_p.P122P|CDHR5_uc001lql.2_Silent_p.P122P|CDHR5_uc001lqm.2_5'UTR|CDHR5_uc009yce.1_Intron	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	122	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						AGGGGAATTCGGGGGCATTGT	0.637													8	98					0	0	0	0	A	621851	A	A	621851	2	1	23	1	0	0	0	0	0	0	0	1	3137	1103	39	1		1	CDHR5	11	621851	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08		621851	134384665	205	4820											
MUC6	4588	broad.mit.edu	37	chr11	1017138	1017138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttggtggggctgtgtgggtgGaccctgtggccttgatcgtg	2	13	19	7	1	0	1	0	1	0	0	1	2	0	2	2	6	0	1	2	6	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:1017138G>A	uc001lsw.2	-	31	5714	c.5663C>T	c.(5662-5664)TCC>TTC	p.S1888F		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1888	Thr-rich.|2.|Approximate repeats.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGTGTGGGTGGACCCTGTGGC	0.567													97	637					0	0	0	0	A	1017138	A	A	1017138	3	1	23	1	0	0	0	0	1	0	0	0	10033	1174	41	2	1668	2	MUC6	11	1017138	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	395287	1017138	133989378	206	4821											
MUC5B	727897	broad.mit.edu	37	chr11	1271273	1271273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctcctccactccggggaCgacctggatcctcacagagc	7	6	9	19	2	1	1	1	0	0	1	5	4	5	3	7	3	1	0	7	3	0	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:1271273C>T	uc009ycr.1	+	51	14708	c.14582C>T	c.(14581-14583)ACG>ATG	p.T4861M	MUC5B_uc001ltb.2_Missense_Mutation_p.T4391M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4388	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACTCCGGGGACGACCTGGATC	0.662													6	124					0	0	0	0	T	1271273	T	T	1271273	3	4	23	1	0	0	0	0	1	0	0	0	10032	536	19	1	13294	1	MUC5B	11	1271273	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	254135	1271273	133735243	207	4822											
BRSK2	9024	broad.mit.edu	37	chr11	1467115	1467115	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctgcgcggcgggccattGagatggcccagcacggccag	6	5	16	14	4	0	1	0	1	0	1	0	2	0	1	4	4	3	1	4	4	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:1467115G>A	uc001lti.2	+	12	1590	c.1204G>A	c.(1204-1206)GAG>AAG	p.E402K	BRSK2_uc009ycv.1_Missense_Mutation_p.E402K|BRSK2_uc001lth.1_Missense_Mutation_p.E402K|BRSK2_uc001ltj.2_Missense_Mutation_p.E402K|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Missense_Mutation_p.E402K|BRSK2_uc001ltm.2_Missense_Mutation_p.E448K|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	402					establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		GCGGGCCATTGAGATGGCCCA	0.716													4	107					0	0	0	0	A	1467115	A	A	1467115	3	1	23	1	0	0	0	0	1	0	0	0	1529	1291	45	2	1250	2	BRSK2	11	1467115	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	195842	1467115	133539401	208	4823											
NUP98	4928	broad.mit.edu	37	chr11	3784171	3784171	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagtattggtctgcccaaaGagacctgttcctgttccaaa	10	11	8	12	0	1	1	0	0	1	1	3	2	3	1	5	1	1	3	5	1	3	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:3784171G>C	uc001lyh.2	-	9	1338	c.1047C>G	c.(1045-1047)CTC>CTG	p.L349L	NUP98_uc001lyi.2_Silent_p.L349L|NUP98_uc001lyj.1_Silent_p.L349L|NUP98_uc001lyk.1_Silent_p.L349L	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	349	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TCTGCCCAAAGAGACCTGTTC	0.443			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								6	193					0	0	0	0	C	3784171	C	C	3784171	2	2	23	1	0	0	0	0	0	0	0	1	10827	929	33	2		2	NUP98	11	3784171	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2317056	3784171	131222345	209	4824											
OR52D1	390066	broad.mit.edu	37	chr11	5510656	5510656	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgatgcccagcacaaagcTctgagtacctgtggctccca	10	8	9	14	0	1	2	0	2	1	0	2	2	2	2	3	1	4	4	3	1	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:5510656T>C	uc010qzg.1	+	1	720	c.720T>C	c.(718-720)GCT>GCC	p.A240A	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	240	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCACAAAGCTCTGAGTACCT	0.512													8	279					0	0	0	0	C	5510656	C	C	5510656	2	2	23	1	0	0	0	0	0	0	0	1	11168	1538	54	5		5	OR52D1	11	5510656	Silent	SNP	T	TCGA-BB-4223-01A-01D-1434-08	1726485	5510656	129495860	210	4825											
C11orf42	160298	broad.mit.edu	37	chr11	6231403	6231403	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catatgggtgacctgcgcaaGaaggttgccttcctgttgct	7	12	12	10	1	0	2	0	1	0	1	1	2	1	2	3	2	3	4	3	2	3	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:6231403G>C	uc001mcj.2	+	2	444	c.396G>C	c.(394-396)AAG>AAC	p.K132N		NM_173525	NP_775796	Q8N5U0	CK042_HUMAN	hypothetical protein LOC160298	132										ovary(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.95e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCTGCGCAAGAAGGTTGCCT	0.552													6	210					0	0	0	0	C	6231403	C	C	6231403	3	2	23	1	0	0	0	0	1	0	0	0	1647	933	33	2	402	2	C11orf42	11	6231403	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	720747	6231403	128775113	211	4826											
CCKBR	887	broad.mit.edu	37	chr11	6291978	6291978	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttagggcttcgctttgaCggcgacagtgacagcgacag	9	9	13	10	4	0	2	0	2	0	0	1	4	0	2	0	2	2	2	0	2	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:6291978C>T	uc001mcp.2	+	4	949	c.756C>T	c.(754-756)GAC>GAT	p.D252D	CCKBR_uc001mcq.2_Silent_p.D180D|CCKBR_uc001mcr.2_Silent_p.D252D|CCKBR_uc001mcs.2_Silent_p.D252D|CCKBR_uc001mct.1_5'Flank	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	252	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TTCGCTTTGACGGCGACAGTG	0.602													61	79					0	0	0	0	T	6291978	T	T	6291978	2	4	23	1	0	0	0	0	0	0	0	1	2894	535	19	1		1	CCKBR	11	6291978	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	60575	6291978	128714538	212	4827											
RRP8	23378	broad.mit.edu	37	chr11	6621416	6621416	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggctgaagctgcaggcctGaaagctgagccttgggccct	8	8	14	11	0	0	3	0	3	0	0	0	3	0	3	3	3	4	4	3	3	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:6621416G>C	uc001med.2	-	7	1410	c.1331C>G	c.(1330-1332)TCA>TGA	p.S444*		NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	444					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0						CTGCAGGCCTGAAAGCTGAGC	0.537													6	128					0	0	0	0	C	6621416	C	C	6621416	4	2	23	1	0	0	0	0	0	1	0	0	13755	1294	45	2	43	2	RRP8	11	6621416	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	329438	6621416	128385100	213	4828											
LYVE1	10894	broad.mit.edu	37	chr11	10585492	10585492	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagatcagactcaccagatGagttgtaacaataggctgca	14	8	10	9	0	2	4	2	1	0	3	2	4	2	4	1	1	2	5	1	1	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:10585492G>A	uc001miv.2	-	3	678	c.392C>T	c.(391-393)TCA>TTA	p.S131L	uc001miu.2_Intron|LYVE1_uc010rca.1_Intron	NM_006691	NP_006682	Q9Y5Y7	LYVE1_HUMAN	lymphatic vessel endothelial hyaluronan receptor	131	Extracellular (Potential).				anatomical structure morphogenesis|cell-matrix adhesion|cellular component movement|response to wounding|transport	integral to plasma membrane|membrane fraction				central_nervous_system(1)|skin(1)	2				all cancers(16;7.22e-08)|Epithelial(150;1.03e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0609)		CTCACCAGATGAGTTGTAACA	0.507													5	83					0	0	0	0	A	10585492	A	A	10585492	3	1	23	1	0	0	0	0	1	0	0	0	9180	1294	45	2	592	2	LYVE1	11	10585492	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3964076	10585492	124421024	214	4829											
CCDC34	91057	broad.mit.edu	37	chr11	27384412	27384412	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctgtaactccattcctctCaggctcgccactttggcctc	5	12	6	18	1	1	0	1	0	1	0	6	0	3	0	5	2	1	2	5	2	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:27384412C>T	uc001mrh.1	-	1	384	c.330G>A	c.(328-330)CTG>CTA	p.L110L	CCDC34_uc001mri.1_Silent_p.L110L	NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	110											0						CCATTCCTCTCAGGCTCGCCA	0.562													9	215					0	0	0	0	T	27384412	T	T	27384412	2	4	23	1	0	0	0	0	0	0	0	1	2820	813	29	2		2	CCDC34	11	27384412	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	16798920	27384412	107622104	215	4830											
CREB3L1	90993	broad.mit.edu	37	chr11	46321584	46321584	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaccctgtgctggatgagaaGagccctctattggacatgga	10	9	13	9	0	1	2	0	1	1	2	1	7	1	5	2	3	2	1	2	3	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:46321584G>C	uc001ncf.2	+	2	636	c.201G>C	c.(199-201)AAG>AAC	p.K67N		NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	67	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)		TGGATGAGAAGAGCCCTCTAT	0.577			T	FUS	myxofibrosarcoma								17	45					0	0	0	0	C	46321584	C	C	46321584	3	2	23	1	0	0	0	0	1	0	0	0	3871	933	33	2	207	2	CREB3L1	11	46321584	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	18937172	46321584	88684932	216	4831											
NUP160	23279	broad.mit.edu	37	chr11	47810131	47810131	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaacactctttctccagatCttccagttccaggatttcaa	10	13	6	12	0	4	1	1	0	3	1	7	3	6	3	3	2	1	1	3	2	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:47810131C>T	uc001ngm.2	-	30	3629	c.3544G>A	c.(3544-3546)GAT>AAT	p.D1182N	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	1182					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						TTCTCCAGATCTTCCAGTTCC	0.413													5	100					0	0	0	0	T	47810131	T	T	47810131	3	4	23	1	0	0	0	0	1	0	0	0	10811	913	32	2	794	2	NUP160	11	47810131	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1488547	47810131	87196385	217	4832											
OR4C12	283093	broad.mit.edu	37	chr11	50003785	50003785	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagatgattttcttctcttGaaaggaatccacaatcaact	13	13	7	8	0	3	3	1	2	2	1	5	5	4	4	1	2	1	0	1	2	4	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:50003785G>A	uc010ria.1	-	1	253	c.253C>T	c.(253-255)CAA>TAA	p.Q85*		NM_001005270	NP_001005270	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TTCTTCTCTTGAAAGGAATCC	0.443													76	125					0	0	0	0	A	50003785	A	A	50003785	4	1	23	1	0	0	0	0	0	1	0	0	11100	1299	45	2	680	2	OR4C12	11	50003785	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2193654	50003785	85002731	218	4833											
SSSCA1	10534	broad.mit.edu	37	chr11	65338884	65338884	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaatgcccaggctgccctCtcccaagctcgggagcacca	8	6	10	17	1	1	1	0	1	1	0	3	2	1	2	4	2	4	3	4	2	2	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:65338884C>G	uc001oek.2	+	4	299	c.279C>G	c.(277-279)CTC>CTG	p.L93L	FAM89B_uc001oen.2_5'Flank|FAM89B_uc001oem.2_5'Flank|FAM89B_uc001oel.2_5'Flank	NM_006396	NP_006387	O60232	SSA27_HUMAN	Sjogren syndrome/scleroderma autoantigen 1	93					cell division|mitosis		protein binding			ovary(1)|skin(1)	2						AGGCTGCCCTCTCCCAAGCTC	0.632													10	158					0	0	0	0	G	65338884	G	G	65338884	2	3	23	1	0	0	0	0	0	0	0	1	15261	900	32	2		2	SSSCA1	11	65338884	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	15335099	65338884	69667632	219	4834											
EFEMP2	30008	broad.mit.edu	37	chr11	65638808	65638808	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttcccccttgcaggcctCagggatggtcagacactcgt	7	10	10	14	1	2	1	2	0	0	1	4	2	3	2	3	3	1	1	3	3	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:65638808C>A	uc001ofy.3	-	4	381	c.187G>T	c.(187-189)GAG>TAG	p.E63*	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Nonsense_Mutation_p.E63*	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	63	EGF-like 1; atypical.				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		TTGCAGGCCTCAGGGATGGTC	0.647													12	236					2.27111e-07	2.351e-07	1	0	A	65638808	A	A	65638808	4	1	23	1	0	0	0	0	0	1	0	0	4964	835	29	2	1176	2	EFEMP2	11	65638808	Nonsense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	299924	65638808	69367708	220	4835											
SYT12	91683	broad.mit.edu	37	chr11	66811231	66811231	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcgatgaggatgagcgcaaCgtcagcacgggggtggtgga	10	6	18	7	4	1	2	1	2	0	0	2	5	1	4	0	5	3	2	0	5	1	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:66811231C>T	uc009yrl.2	+	5	974	c.744C>T	c.(742-744)AAC>AAT	p.N248N	SYT12_uc001oju.2_Silent_p.N248N	NM_177963	NP_808878	Q8IV01	SYT12_HUMAN	synaptotagmin XII	248	C2 1.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane				ovary(1)	1						ATGAGCGCAACGTCAGCACGG	0.547													9	165					0	0	0	0	T	66811231	T	T	66811231	2	4	23	1	0	0	0	0	0	0	0	1	15534	535	19	1		1	SYT12	11	66811231	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1172423	66811231	68195285	221	4836											
POLD4	57804	broad.mit.edu	37	chr11	67120197	67120197	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggtctccggggtgggtcttCagcacctgccacacctctgg	4	9	14	14	1	4	0	1	0	3	0	5	0	4	0	4	5	2	1	4	5	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:67120197C>T	uc001okm.2	-	3	411	c.264G>A	c.(262-264)CTG>CTA	p.L88L	LOC100130987_uc010rpo.1_Intron|POLD4_uc001okn.2_RNA|POLD4_uc001oko.2_RNA|POLD4_uc001okp.1_3'UTR	NM_021173	NP_066996	Q9HCU8	DPOD4_HUMAN	DNA-directed DNA polymerase delta 4	88					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA-directed DNA polymerase activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(15;3.08e-06)			GGTGGGTCTTCAGCACCTGCC	0.662													10	101					0	0	0	0	T	67120197	T	T	67120197	2	4	23	1	0	0	0	0	0	0	0	1	12248	813	29	2		2	POLD4	11	67120197	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	308966	67120197	67886319	222	4837											
SLCO2B1	11309	broad.mit.edu	37	chr11	74914390	74914390	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatccacggcagcgccatcGacaccacctgtgtgcactgg	8	7	11	15	3	0	1	0	1	0	0	2	2	1	1	4	2	2	2	4	2	0	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:74914390G>T	uc001owb.2	+	13	2254	c.1867G>T	c.(1867-1869)GAC>TAC	p.D623Y	SLCO2B1_uc010rrr.1_Missense_Mutation_p.D479Y|SLCO2B1_uc010rrs.1_Missense_Mutation_p.D507Y|SLCO2B1_uc001owc.2_Missense_Mutation_p.D396Y|SLCO2B1_uc001owd.2_Missense_Mutation_p.D601Y	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	623	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	CAGCGCCATCGACACCACCTG	0.632													86	141					7.74691e-53	8.16298e-53	1	0	T	74914390	T	T	74914390	3	4	23	1	0	0	0	0	1	0	0	0	14791	1058	37	3	1917	3	SLCO2B1	11	74914390	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	7794193	74914390	60092126	223	4838											
MMP3	4314	broad.mit.edu	37	chr11	102713291	102713291	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacagcatcttttggcaaatCtggtgtataattcacaatcc	13	13	6	9	0	3	0	1	0	2	0	4	0	4	0	1	2	2	3	1	2	5	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:102713291C>G	uc001phj.1	-	3	435	c.370G>C	c.(370-372)GAT>CAT	p.D124H		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	124		Calcium 1.			collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	TTTGGCAAATCTGGTGTATAA	0.398													6	201					0	0	0	0	G	102713291	G	G	102713291	3	3	23	1	0	0	0	0	1	0	0	0	9719	913	32	2	1095	2	MMP3	11	102713291	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	27798901	102713291	32293225	224	4839											
BCO2	83875	broad.mit.edu	37	chr11	112050030	112050030	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtacatgggaaatactcctCagaaaaaagccgtctttggg	13	9	11	8	1	2	1	1	0	1	1	3	2	3	2	2	3	3	1	2	3	6	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr11:112050030C>G	uc001pnf.2	+	2	235	c.118C>G	c.(118-120)CAG>GAG	p.Q40E	BCO2_uc001pne.1_Intron|BCO2_uc001png.2_Missense_Mutation_p.Q40E|BCO2_uc001pnh.2_Missense_Mutation_p.Q6E|BCO2_uc010rwt.1_Intron|BCO2_uc009yyn.2_Missense_Mutation_p.Q6E|BCO2_uc001pni.2_Missense_Mutation_p.Q6E	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	40					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AAATACTCCTCAGAAAAAAGC	0.478													48	38					0	0	0	0	G	112050030	G	G	112050030	3	3	23	1	0	0	0	0	1	0	0	0	1387	827	29	2	124	2	BCO2	11	112050030	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	9336739	112050030	22956486	225	4840											
LRTM2	654429	broad.mit.edu	37	chr12	1943732	1943732	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaggggtcgtgtgcggcGtcgtctgcatcatgatggtg	4	12	17	8	4	2	1	1	1	1	0	4	1	2	1	0	4	3	2	0	4	0	1	rs146537358	byFrequency	TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:1943732G>A	uc001qjt.2	+	5	1764	c.958G>A	c.(958-960)GTC>ATC	p.V320I	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Missense_Mutation_p.V320I|LRTM2_uc010sdx.1_Missense_Mutation_p.V320I|LRTM2_uc001qjv.2_Missense_Mutation_p.V82I	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	320	Helical; (Potential).					integral to membrane		p.V320I(1)		large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CGTGTGCGGCGTCGTCTGCAT	0.657													18	171					0	0	0	0	A	1943732	A	A	1943732	3	1	23	1	0	0	0	0	1	0	0	0	9095	1145	40	1	968	1	LRTM2	12	1943732	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08		1943732	131908163	226	4841											
DYRK4	8798	broad.mit.edu	37	chr12	4705861	4705861	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaaggactttttctactttCgcaatcacttctgcatcacc	9	15	5	12	1	4	1	2	1	2	0	5	2	4	2	1	1	2	2	1	1	3	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:4705861C>T	uc001qmx.2	+	6	686	c.526C>T	c.(526-528)CGC>TGC	p.R176C	DYRK4_uc009zeh.1_Missense_Mutation_p.R291C|DYRK4_uc001qmy.1_Missense_Mutation_p.R176C	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	176	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			TTTCTACTTTCGCAATCACTT	0.443													42	124					0	0	0	0	T	4705861	T	T	4705861	3	4	23	1	0	0	0	0	1	0	0	0	4880	884	31	1	540	1	DYRK4	12	4705861	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2762129	4705861	129146034	227	4842											
FAM90A1	55138	broad.mit.edu	37	chr12	8375318	8375318	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggtagctgagcgatcagaGaggacagggtccacacgcgg	10	5	16	10	4	1	2	1	1	0	1	3	5	2	3	1	4	2	2	1	4	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:8375318G>A	uc001qui.2	-	7	1054	c.495C>T	c.(493-495)CTC>CTT	p.L165L	FAM90A1_uc001quh.2_Silent_p.L165L	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	165							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		AGCGATCAGAGAGGACAGGGT	0.547													6	158					0	0	0	0	A	8375318	A	A	8375318	2	1	23	1	0	0	0	0	0	0	0	1	5682	929	33	2		2	FAM90A1	12	8375318	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3669457	8375318	125476577	228	4843											
DDN	23109	broad.mit.edu	37	chr12	49391846	49391846	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagatccgaggatccagcctCttctttgtgcgccctccgtc	5	12	9	15	3	2	1	0	0	2	1	6	3	5	2	5	1	2	0	5	1	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:49391846C>G	uc001rsv.1	-	2	831	c.813G>C	c.(811-813)AAG>AAC	p.K271N	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	271						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon		p.K217K(1)		large_intestine(1)	1						GATCCAGCCTCTTCTTTGTGC	0.657													6	270					0	0	0	0	G	49391846	G	G	49391846	3	3	23	1	0	0	0	0	1	0	0	0	4350	912	32	2	1326	2	DDN	12	49391846	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	41016528	49391846	84460049	229	4844											
PRPH	5630	broad.mit.edu	37	chr12	49690818	49690818	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgaagaacctgcaggaggcGgaggagtggtacaagtccaa	13	4	16	8	2	0	1	0	0	0	1	1	5	1	4	2	5	3	2	2	5	5	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:49690818G>A	uc001rtu.2	+	4	924	c.849G>A	c.(847-849)GCG>GCA	p.A283A		NM_006262	NP_006253	P41219	PERI_HUMAN	peripherin	283	Coil 2.|Rod.						structural molecule activity				0						TGCAGGAGGCGGAGGAGTGGT	0.672											OREG0021790	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	103					0	0	0	0	A	49690818	A	A	49690818	2	1	23	1	0	0	0	0	0	0	0	1	12638	1103	39	1		1	PRPH	12	49690818	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	298972	49690818	84161077	230	4845											
AAAS	8086	broad.mit.edu	37	chr12	53702757	53702757	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcttacctgacagcgccctGatagagtaggccacctctca	9	9	8	15	1	2	3	1	2	2	1	3	3	2	3	4	1	2	1	4	1	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:53702757G>A	uc001scr.3	-	10	1146	c.983C>T	c.(982-984)TCA>TTA	p.S328L	AAAS_uc001scs.3_Missense_Mutation_p.S295L	NM_015665	NP_056480	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency,	328					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				ovary(1)	1						ACAGCGCCCTGATAGAGTAGG	0.522													16	439					0	0	0	0	A	53702757	A	A	53702757	3	1	23	1	0	0	0	0	1	0	0	0	8	1294	45	2	685	2	AAAS	12	53702757	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4011939	53702757	80149138	231	4846											
AAAS	8086	broad.mit.edu	37	chr12	53702953	53702953	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccactcaccgaaagacagctGaaggagtggtagccaggatt	13	6	12	10	1	1	2	1	1	0	1	1	5	1	4	3	3	2	2	3	3	3	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:53702953G>A	uc001scr.3	-	9	1086	c.923C>T	c.(922-924)TCA>TTA	p.S308L	AAAS_uc001scs.3_Missense_Mutation_p.S275L	NM_015665	NP_056480	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency,	308	WD 4.				carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				ovary(1)	1						AAAGACAGCTGAAGGAGTGGT	0.577													26	583					0	0	0	0	A	53702953	A	A	53702953	3	1	23	1	0	0	0	0	1	0	0	0	8	1294	45	2	749	2	AAAS	12	53702953	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	196	53702953	80148942	232	4847											
TIMELESS	8914	broad.mit.edu	37	chr12	56812008	56812008	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctttacagtgctcctcatCagagccttgctctccaggga	7	12	8	14	0	4	1	2	0	2	1	6	2	5	2	3	1	4	2	3	1	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:56812008C>G	uc001slf.2	-	27	3532	c.3364G>C	c.(3364-3366)GAT>CAT	p.D1122H		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	1122					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						TGCTCCTCATCAGAGCCTTGC	0.582													25	844					0	0	0	0	G	56812008	G	G	56812008	3	3	23	1	0	0	0	0	1	0	0	0	15970	826	29	2	274	2	TIMELESS	12	56812008	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	3109055	56812008	77039887	233	4848											
GPR182	11318	broad.mit.edu	37	chr12	57389816	57389816	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgtgctggctgccctatCatgtgaccctgctgctgctc	4	13	10	14	0	2	1	2	1	0	0	3	1	2	1	2	1	5	5	2	1	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:57389816C>A	uc001smk.2	+	2	917	c.823C>A	c.(823-825)CAT>AAT	p.H275N	RDH16_uc010sqx.1_Intron	NM_007264	NP_009195	O15218	GP182_HUMAN	G protein-coupled receptor 182	275	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(1)	1						GCTGCCCTATCATGTGACCCT	0.607													11	519					0.00010058	0.000103082	1	0	A	57389816	A	A	57389816	3	1	23	1	0	0	0	0	1	0	0	0	6715	826	29	2	825	2	GPR182	12	57389816	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	577808	57389816	76462079	234	4849											
PPM1H	57460	broad.mit.edu	37	chr12	63225906	63225906	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcttaccgagttctccttCagctgcagcccttccccatt	5	13	7	16	1	3	0	1	0	2	0	5	1	4	0	5	1	4	3	5	1	1	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:63225906C>T	uc001srk.3	-	2	548	c.399G>A	c.(397-399)CTG>CTA	p.L133L		NM_020700	NP_065751	Q9ULR3	PPM1H_HUMAN	protein phosphatase 1H (PP2C domain containing)	133							phosphoprotein phosphatase activity			lung(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		AGTTCTCCTTCAGCTGCAGCC	0.532													39	44					0	0	0	0	T	63225906	T	T	63225906	2	4	23	1	0	0	0	0	0	0	0	1	12401	813	29	2		2	PPM1H	12	63225906	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	5836090	63225906	70625989	235	4850											
KCNMB4	27345	broad.mit.edu	37	chr12	70824287	70824287	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagatgatgtgcttctgcatCgcactcatgatgagattgtc	9	13	10	9	1	2	4	1	3	1	2	4	5	2	4	0	0	2	3	0	0	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:70824287C>T	uc001svx.2	+	3	940	c.487C>T	c.(487-489)CGC>TGC	p.R163C	uc001svy.1_5'Flank	NM_014505	NP_055320	Q86W47	KCMB4_HUMAN	calcium-activated potassium channel beta 4	163	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding				0	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			GCTTCTGCATCGCACTCATGA	0.483													15	429					0	0	0	0	T	70824287	T	T	70824287	3	4	23	1	0	0	0	0	1	0	0	0	8116	884	31	1	497	1	KCNMB4	12	70824287	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	7598381	70824287	63027608	236	4851											
PWP1	11137	broad.mit.edu	37	chr12	108082473	108082473	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtgcacgcacccaggcacgCccaagagagcccctggagga	11	2	13	15	2	0	1	0	0	0	1	0	4	0	3	4	3	2	3	4	3	1	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:108082473C>T	uc001tmo.1	+	3	300	c.213C>T	c.(211-213)CGC>CGT	p.R71R	PWP1_uc001tmn.1_RNA|PWP1_uc009zuu.1_Silent_p.R71R	NM_007062	NP_008993	Q13610	PWP1_HUMAN	periodic tryptophan protein 1	71					transcription, DNA-dependent	nucleus					0						CCCAGGCACGCCCAAGAGAGC	0.522													39	100					0	0	0	0	T	108082473	T	T	108082473	2	4	23	1	0	0	0	0	0	0	0	1	12908	726	26	4		4	PWP1	12	108082473	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	37258186	108082473	25769422	237	4852											
SART3	9733	broad.mit.edu	37	chr12	108939002	108939002	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatgtaaaccaacagacgaGagagccctttcaaacacgga	17	6	8	10	2	1	2	1	0	0	2	1	5	1	3	2	1	4	1	2	1	5	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:108939002G>C	uc001tmz.1	-	4	877	c.642C>G	c.(640-642)CTC>CTG	p.L214L	SART3_uc009zux.1_5'UTR|SART3_uc010swx.1_Silent_p.L214L|SART3_uc010swy.1_Silent_p.L82L|SART3_uc010swz.1_Silent_p.L214L|SART3_uc001tna.1_RNA	NM_014706	NP_055521	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T	214	HAT 3.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			pancreas(1)	1						CAACAGACGAGAGAGCCCTTT	0.507									Porokeratosis				145	120					0	0	0	0	C	108939002	C	C	108939002	2	2	23	1	0	0	0	0	0	0	0	1	13912	929	33	2		2	SART3	12	108939002	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	856529	108939002	24912893	238	4853											
ACACB	32	broad.mit.edu	37	chr12	109647006	109647006	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagctcatgatgaccctcCggcacccgtcactgccgctg	8	7	10	16	3	2	3	2	2	0	1	3	3	3	3	4	1	2	3	4	1	1	0	rs146548721		TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:109647006C>T	uc001tob.2	+	21	3216	c.3097C>T	c.(3097-3099)CGG>TGG	p.R1033W	ACACB_uc001toc.2_Missense_Mutation_p.R1033W	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1033					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GATGACCCTCCGGCACCCGTC	0.662													8	24					0	0	0	0	T	109647006	T	T	109647006	3	4	23	1	0	0	0	0	1	0	0	0	107	643	23	1	3175	1	ACACB	12	109647006	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	708004	109647006	24204889	239	4854											
GCN1L1	10985	broad.mit.edu	37	chr12	120594339	120594339	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacgtccacctcctcctgctCtgcaaaggcacagccatcat	9	8	6	18	1	2	0	1	0	1	0	5	0	5	0	5	1	3	3	5	1	1	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:120594339C>G	uc001txo.2	-	28	3251	c.3238G>C	c.(3238-3240)GAG>CAG	p.E1080Q		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1080	HEAT 4.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCCTCCTGCTCTGCAAAGGCA	0.597													3	87					0	0	0	0	G	120594339	G	G	120594339	3	3	23	1	0	0	0	0	1	0	0	0	6334	922	32	2	4901	2	GCN1L1	12	120594339	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	10947333	120594339	13257556	240	4855											
PXN	5829	broad.mit.edu	37	chr12	120652792	120652792	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccacgtcttccccatggCggtcacaacctgaggaggag	8	7	13	13	2	2	1	1	1	1	0	3	3	3	3	4	4	2	0	4	4	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:120652792C>T	uc001txt.2	-	9	1245	c.1114G>A	c.(1114-1116)GCC>ACC	p.A372T	PXN_uc001txu.2_Missense_Mutation_p.A184T|PXN_uc001txv.2_Missense_Mutation_p.A253T|PXN_uc001txx.2_Missense_Mutation_p.A205T|PXN_uc001txy.2_Missense_Mutation_p.A338T|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	372	LIM zinc-binding 1.				cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCCCCATGGCGGTCACAACC	0.662													19	12					0	0	0	0	T	120652792	T	T	120652792	3	4	23	1	0	0	0	0	1	0	0	0	12917	768	27	1	677	1	PXN	12	120652792	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	58453	120652792	13199103	241	4856											
WDR66	144406	broad.mit.edu	37	chr12	122359293	122359293	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aagaagaggaggaacctaatCcaaattataaagaagtagaa	22	6	9	4	0	0	4	0	0	0	4	1	6	1	6	2	2	1	1	2	2	11	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:122359293C>G	uc009zxk.2	+	2	224	c.82C>G	c.(82-84)CCA>GCA	p.P28A		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	28	Glu-rich.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GGAACCTAATCCAAATTATAA	0.348													3	78					0	0	0	0	G	122359293	G	G	122359293	3	3	23	1	0	0	0	0	1	0	0	0	17385	855	30	2	84	2	WDR66	12	122359293	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1706501	122359293	11492602	242	4857											
LRRC43	254050	broad.mit.edu	37	chr12	122677376	122677376	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtcatcgaagacattgttGaagaggttactgaagaggtc	13	10	12	6	2	1	5	1	2	0	3	3	6	1	5	0	2	1	2	0	2	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr12:122677376G>A	uc009zxm.2	+	7	1199	c.1174G>A	c.(1174-1176)GAA>AAA	p.E392K	LRRC43_uc001ubw.3_Missense_Mutation_p.E207K|LRRC43_uc009zxn.2_Missense_Mutation_p.E153K	NM_001098519	NP_001091989	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43 isoform 1	392	Glu-rich.										0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		AGACATTGTTGAAGAGGTTAC	0.517													7	192					0	0	0	0	A	122677376	A	A	122677376	3	1	23	1	0	0	0	0	1	0	0	0	9051	1291	45	2	1200	2	LRRC43	12	122677376	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	318083	122677376	11174519	243	4858											
XPO4	64328	broad.mit.edu	37	chr13	21429888	21429888	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctagtagaatctgttcccGaacatacttttgaaggctgt	10	14	9	8	1	1	2	0	1	1	1	2	3	2	2	1	1	3	4	1	1	6	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr13:21429888G>A	uc001unq.3	-	4	370	c.334C>T	c.(334-336)CGG>TGG	p.R112W	XPO4_uc010tcr.1_Missense_Mutation_p.R38W	NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	112					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		ATCTGTTCCCGAACATACTTT	0.328													9	206					0	0	0	0	A	21429888	A	A	21429888	3	1	23	1	0	0	0	0	1	0	0	0	17514	1057	37	1	3201	1	XPO4	13	21429888	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08		21429888	93739990	244	4859											
SACS	26278	broad.mit.edu	37	chr13	23906424	23906424	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatctaattgtttgccctcaGaatttttaaatatgcggctc	10	16	7	8	1	2	1	1	0	1	1	3	2	2	1	1	1	2	2	1	1	5	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr13:23906424G>C	uc001uon.2	-	10	12180	c.11591C>G	c.(11590-11592)TCT>TGT	p.S3864C	SACS_uc001uoo.2_Missense_Mutation_p.S3717C|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3864					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTTGCCCTCAGAATTTTTAAA	0.373													13	231					0	0	0	0	C	23906424	C	C	23906424	3	2	23	1	0	0	0	0	1	0	0	0	13869	942	33	2	2152	2	SACS	13	23906424	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2476536	23906424	91263454	245	4860											
ENOX1	55068	broad.mit.edu	37	chr13	43930093	43930093	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagagcggcttcgtgctccGagtagtgcattatggcaggc	7	9	15	10	3	0	1	0	0	0	1	2	2	1	1	1	3	3	6	1	3	2	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr13:43930093G>A	uc001uza.3	-	8	1085	c.785C>T	c.(784-786)TCG>TTG	p.S262L	ENOX1_uc001uzb.3_Missense_Mutation_p.S262L|ENOX1_uc001uzc.3_Missense_Mutation_p.S262L|ENOX1_uc001uyz.3_5'UTR|ENOX1_uc010tfm.1_Missense_Mutation_p.S75L	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	262					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		TTCGTGCTCCGAGTAGTGCAT	0.637													14	207					0	0	0	0	A	43930093	A	A	43930093	3	1	23	1	0	0	0	0	1	0	0	0	5150	1059	37	1	1186	1	ENOX1	13	43930093	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	20023669	43930093	71239785	246	4861											
RCBTB1	55213	broad.mit.edu	37	chr13	50125565	50125565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggcatacagcaagccctCatctgttagtgctagagtat	11	10	9	11	0	2	1	1	0	1	1	2	1	2	1	2	1	4	5	2	1	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr13:50125565C>T	uc001vde.1	-	8	1012	c.751G>A	c.(751-753)GAG>AAG	p.E251K		NM_018191	NP_060661	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and	251					cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		AGCAAGCCCTCATCTGTTAGT	0.473													4	115					0	0	0	0	T	50125565	T	T	50125565	3	4	23	1	0	0	0	0	1	0	0	0	13236	835	29	2	868	2	RCBTB1	13	50125565	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	6195472	50125565	65044313	247	4862											
FAM155A	728215	broad.mit.edu	37	chr13	108518355	108518355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcccccccggccgcccccCgactccagttcctggcgcac	3	5	9	24	5	0	0	0	0	0	0	3	1	3	0	9	2	0	2	9	2	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr13:108518355C>T	uc001vql.2	-	1	1106	c.590G>A	c.(589-591)CGG>CAG	p.R197Q		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	197						integral to membrane	binding			skin(1)	1						GGCCGCCCCCCGACTCCAGTT	0.632													29	217					0	0	0	0	T	108518355	T	T	108518355	3	4	23	1	0	0	0	0	1	0	0	0	5493	652	23	1	798	1	FAM155A	13	108518355	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	58392790	108518355	6651523	248	4863											
CPNE6	9362	broad.mit.edu	37	chr14	24545039	24545039	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cctctccctacctccaggtgGagaaggtgcacaccttcctg	7	9	9	16	0	1	1	0	0	1	1	4	2	3	1	6	3	2	1	6	3	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr14:24545039G>C	uc001wll.2	+	10	967	c.868G>C	c.(868-870)GAG>CAG	p.E290Q	CPNE6_uc010tnv.1_Missense_Mutation_p.E345Q|CPNE6_uc001wlm.2_Missense_Mutation_p.E115Q|CPNE6_uc001wln.2_5'UTR	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	290					lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		CCTCCAGGTGGAGAAGGTGCA	0.602													3	100					0	0	0	0	C	24545039	C	C	24545039	3	2	23	1	0	0	0	0	1	0	0	0	3831	1175	41	2	902	2	CPNE6	14	24545039	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08		24545039	82804501	249	4864											
C14orf149	112849	broad.mit.edu	37	chr14	59939793	59939793	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactataacagctttaaaatCaccacatttcgcttcctgaa	14	12	3	12	1	1	1	1	1	0	0	3	1	2	1	2	0	2	2	2	0	5	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr14:59939793C>G	uc001xee.1	-	5	994	c.955G>C	c.(955-957)GAT>CAT	p.D319H		NM_144581	NP_653182	Q96EM0	PRCM_HUMAN	proline racemase-like	319							proline racemase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.14)	L-Proline(DB00172)	GCTTTAAAATCACCACATTTC	0.373													5	162					0	0	0	0	G	59939793	G	G	59939793	3	3	23	1	0	0	0	0	1	0	0	0	1758	826	29	2	113	2	C14orf149	14	59939793	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	35394754	59939793	47409747	250	4865											
SYT16	83851	broad.mit.edu	37	chr14	62547795	62547795	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagagagggcccaaccccGtcttcagggagaaggtcacc	11	5	12	13	1	3	2	2	0	1	2	3	4	3	2	4	3	2	0	4	3	3	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr14:62547795G>A	uc001xfu.1	+	4	1434	c.1237G>A	c.(1237-1239)GTC>ATC	p.V413I	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_5'UTR	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	413	C2 1.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GCCCAACCCCGTCTTCAGGGA	0.582													22	28					0	0	0	0	A	62547795	A	A	62547795	3	1	23	1	0	0	0	0	1	0	0	0	15538	1145	40	1	1251	1	SYT16	14	62547795	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2608002	62547795	44801745	251	4866											
CALM1	801	broad.mit.edu	37	chr14	90870274	90870274	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatgaaagatacagatagtGaagaagaaatccgtgaggca	20	6	11	4	1	0	7	0	3	0	4	1	7	1	7	1	1	1	1	1	1	7	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr14:90870274G>A	uc001xyl.1	+	4	449	c.247G>A	c.(247-249)GAA>AAA	p.E83K	CALM1_uc010atq.1_Missense_Mutation_p.E84K|CALM1_uc010atr.1_Intron|CALM1_uc001xym.1_Missense_Mutation_p.E47K	NM_006888	NP_008819	P62158	CALM_HUMAN	calmodulin 1 isoform 1	83	EF-hand 3.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			central_nervous_system(1)	1		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.208)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	TACAGATAGTGAAGAAGAAAT	0.383													33	21					0	0	0	0	A	90870274	A	A	90870274	3	1	23	1	0	0	0	0	1	0	0	0	2596	1291	45	2	261	2	CALM1	14	90870274	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	28322479	90870274	16479266	252	4867											
RPS6KA5	9252	broad.mit.edu	37	chr14	91366509	91366509	+	Frame_Shift_Del	DEL	C	-	-																															tttttttatgcacacactttCgacaaattgaaaaactacct																										TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr14:91366509delC	uc001xys.2	-	11	1537	c.1322delG	c.(1321-1323)CGAfs	p.R441fs	RPS6KA5_uc010twi.1_Frame_Shift_Del_p.R362fs|RPS6KA5_uc001xyt.2_Frame_Shift_Del_p.R441fs	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	441	Protein kinase 2.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		CACACACTTTCGACAAATTGA	0.333													---	---	---								-	91366509	-	-	91366509	7	5	23	1	0	1	0	1	0	0	0	0	13719	884	31	0	1120	0	RPS6KA5	14	91366509	Frame_Shift_Del	DEL	C	TCGA-BB-4223-01A-01D-1434-08	496235	91366509	15983031	253	4868											
DYNC1H1	1778	broad.mit.edu	37	chr14	102452268	102452268	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccggatcaccgctcgccttcGggatcagcttggcacagcca	7	7	11	16	4	2	0	2	0	0	0	4	2	2	2	4	3	2	3	4	3	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr14:102452268G>A	uc001yks.2	+	8	1870	c.1706G>A	c.(1705-1707)CGG>CAG	p.R569Q		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	569	Interaction with DYNC1I2 (By similarity).|Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GCTCGCCTTCGGGATCAGCTT	0.547													38	27					0	0	0	0	A	102452268	A	A	102452268	3	1	23	1	0	0	0	0	1	0	0	0	4863	1116	39	1	1736	1	DYNC1H1	14	102452268	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	11085759	102452268	4897272	254	4869											
MTMR15	22909	broad.mit.edu	37	chr15	31218129	31218129	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggcccattacagacgcagCggttttgaccagggtaactg	9	9	12	11	2	0	2	0	1	0	1	0	2	0	2	2	3	3	3	2	3	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr15:31218129C>T	uc001zff.2	+	10	2766	c.2475C>T	c.(2473-2475)AGC>AGT	p.S825S	MTMR15_uc001zfe.2_Silent_p.S430S	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	825					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		ACAGACGCAGCGGTTTTGACC	0.627								Direct_reversal_of_damage|Editing_and_processing_nucleases					22	277					0	0	0	0	T	31218129	T	T	31218129	2	4	23	1	0	0	0	0	0	0	0	1	9996	767	27	1		1	MTMR15	15	31218129	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08		31218129	71313263	255	4870											
TYRO3	7301	broad.mit.edu	37	chr15	41864735	41864735	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacctgcatgccttcctgctCgcctcccggattggggagaa	6	9	12	14	2	0	1	0	0	0	1	3	4	2	2	5	3	3	2	5	3	1	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr15:41864735C>T	uc001zof.1	+	15	2072	c.1848C>T	c.(1846-1848)CTC>CTT	p.L616L		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	616	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CCTTCCTGCTCGCCTCCCGGA	0.617													4	83					0	0	0	0	T	41864735	T	T	41864735	2	4	23	1	0	0	0	0	0	0	0	1	16882	871	31	1		1	TYRO3	15	41864735	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	10646606	41864735	60666657	256	4871											
VPS39	23339	broad.mit.edu	37	chr15	42457948	42457948	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccagacccttaaaattctCtattaagaagccgaggactc	14	9	7	11	1	1	2	0	0	1	2	3	4	1	3	3	1	2	0	3	1	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr15:42457948C>G	uc001zpd.2	-	18	1931	c.1780G>C	c.(1780-1782)GAG>CAG	p.E594Q	VPS39_uc001zpc.2_Missense_Mutation_p.E583Q|VPS39_uc001zpb.2_5'UTR	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	594					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		TTAAAATTCTCTATTAAGAAG	0.443													8	148					0	0	0	0	G	42457948	G	G	42457948	3	3	23	1	0	0	0	0	1	0	0	0	17277	922	32	2	916	2	VPS39	15	42457948	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	593213	42457948	60073444	257	4872											
PLDN	26258	broad.mit.edu	37	chr15	45898619	45898619	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcacttaaactgcagcagaaGaggcaaaaagaagagttgga	18	5	12	6	0	0	4	0	0	0	4	0	5	0	5	0	2	3	5	0	2	6	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr15:45898619G>C	uc001zvq.2	+	5	651	c.426G>C	c.(424-426)AAG>AAC	p.K142N	PLDN_uc001zvr.2_RNA|PLDN_uc001zvs.2_RNA	NM_012388	NP_036520	Q9UL45	PLDN_HUMAN	pallidin	142	Potential.				post-Golgi vesicle-mediated transport|synaptic vesicle docking involved in exocytosis	BLOC-1 complex|endomembrane system|membrane	identical protein binding|syntaxin-13 binding			skin(1)	1		Lung NSC(122;1.6e-06)|all_lung(180;1.13e-05)|Melanoma(134;0.027)		all cancers(107;6.58e-18)|GBM - Glioblastoma multiforme(94;5.91e-07)		TGCAGCAGAAGAGGCAAAAAG	0.383													7	183					0	0	0	0	C	45898619	C	C	45898619	3	2	23	1	0	0	0	0	1	0	0	0	12106	933	33	2	444	2	PLDN	15	45898619	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3440671	45898619	56632773	258	4873											
RFX7	64864	broad.mit.edu	37	chr15	56387891	56387891	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatggtagctgctgaaagctGttccacaattggtttcttta	9	16	9	7	0	1	1	0	1	1	0	2	1	2	1	1	2	3	6	1	2	5	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr15:56387891G>A	uc010bfn.2	-	9	2035	c.2035C>T	c.(2035-2037)CAG>TAG	p.Q679*	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Nonsense_Mutation_p.Q493*	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	582					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						GCTGAAAGCTGTTCCACAATT	0.448													10	197					0	0	0	0	A	56387891	A	A	56387891	4	1	23	1	0	0	0	0	0	1	0	0	13333	1386	48	4	2351	4	RFX7	15	56387891	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	10489272	56387891	46143501	259	4874											
HERC1	8925	broad.mit.edu	37	chr15	63972741	63972741	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgggtgtcggtacctctcCatttttcccaaaagaaatgg	11	12	9	9	1	1	1	0	0	1	1	4	1	2	1	3	3	1	1	3	3	5	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr15:63972741C>T	uc002amp.2	-	35	6608	c.6460G>A	c.(6460-6462)GGA>AGA	p.G2154R		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2154	B30.2/SPRY.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GGTACCTCTCCATTTTTCCCA	0.388													4	74					0	0	0	0	T	63972741	T	T	63972741	3	4	23	1	0	0	0	0	1	0	0	0	7096	603	21	4	8301	4	HERC1	15	63972741	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	7584850	63972741	38558651	260	4875											
PTPLAD1	51495	broad.mit.edu	37	chr15	65847227	65847227	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatttctttctttatagctCaaggacatggtgccaaagga	12	13	8	8	0	3	0	1	0	2	0	3	2	3	2	1	3	2	1	1	3	4	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr15:65847227C>G	uc002apc.2	+	3	281	c.133C>G	c.(133-135)CAA>GAA	p.Q45E	PTPLAD1_uc002apb.1_RNA|PTPLAD1_uc010uiw.1_Missense_Mutation_p.Q45E	NM_016395	NP_057479	Q9P035	HACD3_HUMAN	protein tyrosine phosphatase-like A domain	45	CS.|Cytoplasmic (Potential).				activation of JUN kinase activity|fatty acid biosynthetic process|I-kappaB kinase/NF-kappaB cascade|Rac protein signal transduction	endoplasmic reticulum membrane|integral to membrane	GTPase activator activity|lyase activity|protein binding				0						CTTTATAGCTCAAGGACATGG	0.433													7	254					0	0	0	0	G	65847227	G	G	65847227	3	3	23	1	0	0	0	0	1	0	0	0	12838	827	29	2	143	2	PTPLAD1	15	65847227	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1874486	65847227	36684165	261	4876											
ISLR2	57611	broad.mit.edu	37	chr15	74425126	74425126	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgggccctgtggttggtcTgggcgcttctaggagtggcc	2	12	17	10	2	2	0	0	0	2	0	3	1	2	1	2	6	0	2	2	6	1	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr15:74425126T>G	uc002axd.2	+	4	800	c.31T>G	c.(31-33)TGG>GGG	p.W11G	ISLR2_uc002axe.2_Missense_Mutation_p.W11G|ISLR2_uc010bjg.2_Missense_Mutation_p.W11G|ISLR2_uc010bjf.2_Missense_Mutation_p.W11G	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	11					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						GTGGTTGGTCTGGGCGCTTCT	0.607													40	58					0	0	0	0	G	74425126	G	G	74425126	3	3	23	1	0	0	0	0	1	0	0	0	7898	1580	55	5	33	5	ISLR2	15	74425126	Missense_Mutation	SNP	T	TCGA-BB-4223-01A-01D-1434-08	8577899	74425126	28106266	262	4877											
PLIN1	5346	broad.mit.edu	37	chr15	90210857	90210857	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaacttgttctcctcagtCtccaattcttcctcctcctc	5	16	3	17	0	4	1	1	1	3	0	10	1	7	1	5	0	1	1	5	0	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr15:90210857C>T	uc010upx.1	-	7	1049	c.939G>A	c.(937-939)GAG>GAA	p.E313E	PLIN1_uc002boh.2_Silent_p.E313E	NM_001145311	NP_001138783	O60240	PLIN1_HUMAN	perilipin 1	313	Poly-Glu.				triglyceride catabolic process	lipid particle	lipid binding			central_nervous_system(1)|skin(1)	2						tctcctcagtctccaattctt	0.388													5	52					0	0	0	0	T	90210857	T	T	90210857	2	4	23	1	0	0	0	0	0	0	0	1	12144	912	32	2		2	PLIN1	15	90210857	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	15785731	90210857	12320535	263	4878											
MVP	9961	broad.mit.edu	37	chr16	29853148	29853148	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaggtgtacgactaccgaGagaagcgagcccggtgagtg	10	6	16	9	4	0	2	0	1	0	1	0	6	0	2	2	2	5	2	2	2	3	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr16:29853148G>A	uc002dui.2	+	9	1507	c.1423G>A	c.(1423-1425)GAG>AAG	p.E475K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010vdz.1_RNA|MVP_uc002duj.2_Missense_Mutation_p.E475K|MVP_uc010vea.1_Missense_Mutation_p.E69K	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	475	MVP 9.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CGACTACCGAGAGAAGCGAGC	0.662													4	73					0	0	0	0	A	29853148	A	A	29853148	3	1	23	1	0	0	0	0	1	0	0	0	10049	943	33	2	1453	2	MVP	16	29853148	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08		29853148	60501605	264	4879											
ALDOA	226	broad.mit.edu	37	chr16	30080707	30080707	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgctgccagtatgtgaccgaGaaggtaaatggctacctgcc	10	8	12	11	2	0	2	0	1	0	1	0	3	0	2	4	2	3	4	4	2	5	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr16:30080707G>C	uc002dvw.2	+	9	1749	c.621G>C	c.(619-621)GAG>GAC	p.E207D	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ALDOA_uc002dvx.2_Missense_Mutation_p.E207D|ALDOA_uc002dvy.2_Missense_Mutation_p.E207D|ALDOA_uc002dvz.2_Missense_Mutation_p.E207D|ALDOA_uc002dwa.3_Missense_Mutation_p.E207D|ALDOA_uc002dwb.1_Missense_Mutation_p.E207D|ALDOA_uc002dwc.2_Missense_Mutation_p.E207D|ALDOA_uc010veg.1_Missense_Mutation_p.E261D|ALDOA_uc002dwd.2_Missense_Mutation_p.E211D	NM_184043	NP_908932	P04075	ALDOA_HUMAN	fructose-bisphosphate aldolase A	207			E -> K (in GSD12; reduces thermal stability; 3-fold decrease in catalytic efficiency mostly due to reduced substrate affinity).		actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			lung(1)	1						ATGTGACCGAGAAGGTAAATG	0.622											OREG0023729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	160					0	0	0	0	C	30080707	C	C	30080707	3	2	23	1	0	0	0	0	1	0	0	0	507	933	33	2	639	2	ALDOA	16	30080707	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	227559	30080707	60274046	265	4880											
SRCAP	10847	broad.mit.edu	37	chr16	30727497	30727497	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaagcgtcaacgctgtctCtatgatgacttcatggcaca	10	11	8	12	2	3	2	2	2	1	0	5	2	4	2	1	1	2	2	1	1	3	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr16:30727497C>G	uc002dze.1	+	17	2989	c.2604C>G	c.(2602-2604)CTC>CTG	p.L868L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.L725L|SRCAP_uc010bzz.1_Silent_p.L438L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	868					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			AACGCTGTCTCTATGATGACT	0.512													10	173					0	0	0	0	G	30727497	G	G	30727497	2	3	23	1	0	0	0	0	0	0	0	1	15201	900	32	2		2	SRCAP	16	30727497	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	646790	30727497	59627256	266	4881											
KCTD19	146212	broad.mit.edu	37	chr16	67329284	67329284	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgatccagtacactctctGagggttggacagcagttctg	8	12	12	9	0	2	2	0	2	2	0	4	3	3	3	1	2	2	4	1	2	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr16:67329284G>C	uc002esu.2	-	9	1324	c.1273C>G	c.(1273-1275)CAG>GAG	p.Q425E	KCTD19_uc002est.2_Missense_Mutation_p.Q197E|KCTD19_uc010vjj.1_Missense_Mutation_p.Q168E	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	425	BTB 2.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TACACTCTCTGAGGGTTGGAC	0.527													3	93					0	0	0	0	C	67329284	C	C	67329284	3	2	23	1	0	0	0	0	1	0	0	0	8145	1299	45	2	1539	2	KCTD19	16	67329284	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	36601787	67329284	23025469	267	4882											
CIRH1A	84916	broad.mit.edu	37	chr16	69184786	69184786	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagaattacgatgccgctctCcgaaaaatcacctttcccca	13	9	5	14	3	2	1	1	0	1	1	4	3	3	1	5	0	2	1	5	0	5	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr16:69184786C>T	uc002ews.3	+	8	1077	c.981C>T	c.(979-981)CTC>CTT	p.L327L	CIRH1A_uc002ewr.2_Silent_p.L327L|CIRH1A_uc002ewt.3_Silent_p.L244L|CIRH1A_uc010cfi.2_Silent_p.L244L|CIRH1A_uc010cfj.1_Silent_p.L146L	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	327	WD 8.					nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		ATGCCGCTCTCCGAAAAATCA	0.527													9	179					0	0	0	0	T	69184786	T	T	69184786	2	4	23	1	0	0	0	0	0	0	0	1	3449	842	30	2		2	CIRH1A	16	69184786	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1855502	69184786	21169967	268	4883											
RFWD3	55159	broad.mit.edu	37	chr16	74660297	74660297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggatgttgccatcattctCtgggctttggaaaatggcat	9	13	11	8	0	2	0	1	0	1	0	3	2	2	2	1	4	1	3	1	4	2	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr16:74660297C>T	uc002fda.2	-	12	2223	c.2125G>A	c.(2125-2127)GAG>AAG	p.E709K	RFWD3_uc010vmx.1_Missense_Mutation_p.E229K|RFWD3_uc010cgq.2_Missense_Mutation_p.E709K	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	709					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						CCATCATTCTCTGGGCTTTGG	0.423													12	387					0	0	0	0	T	74660297	T	T	74660297	3	4	23	1	0	0	0	0	1	0	0	0	13326	922	32	2	207	2	RFWD3	16	74660297	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	5475511	74660297	15694456	269	4884											
ZFP1	162239	broad.mit.edu	37	chr16	75203689	75203689	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcccataaggccaacctCatcaaacatcagagaattca	15	9	4	13	0	5	1	4	0	1	1	6	2	5	1	3	1	2	0	3	1	4	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr16:75203689C>T	uc002fdo.2	+	4	845	c.681C>T	c.(679-681)CTC>CTT	p.L227L	ZFP1_uc002fdp.2_Silent_p.L172L|ZFP1_uc010cgt.2_Silent_p.L194L|ZFP1_uc010cgs.2_Silent_p.L172L|ZFP1_uc002fdq.2_Silent_p.L227L	NM_153688	NP_710155	Q6P2D0	ZFP1_HUMAN	zinc finger protein 1 homolog	227	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						AGGCCAACCTCATCAAACATC	0.423													25	52					0	0	0	0	T	75203689	T	T	75203689	2	4	23	1	0	0	0	0	0	0	0	1	17703	813	29	2		2	ZFP1	16	75203689	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	543392	75203689	15151064	270	4885											
TMEM231	79583	broad.mit.edu	37	chr16	75579249	75579249	+	Splice_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacaatgagaagcgctcttaCgttgtatcgggcatctaggc	10	10	12	9	3	2	1	0	1	2	1	3	3	2	1	0	2	2	4	0	2	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr16:75579249C>T	uc002fem.2	-	4	645	c.582_splice	c.e4+1	p.N194_splice	CHST5_uc002fej.1_Intron|TMEM231_uc002fek.2_Splice_Site_p.N223_splice|TMEM231_uc002fel.2_Splice_Site_p.N78_splice|TMEM231_uc010vne.1_Intron|TMEM231_uc010cgx.1_Splice_Site_p.N158_splice	NM_001077418	NP_001070886	Q9H6L2	TM231_HUMAN	transmembrane protein 231 isoform 2							integral to membrane					0						AGCGCTCTTACGTTGTATCGG	0.468													71	148					0	0	0	0	T	75579249	T	T	75579249	5	4	23	1	0	0	0	0	0	0	1	0	16215	550	19	1	383	1	TMEM231	16	75579249	Splice_Site	SNP	C	TCGA-BB-4223-01A-01D-1434-08	375560	75579249	14775504	271	4886											
CENPN	55839	broad.mit.edu	37	chr16	81045655	81045655	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtctgaaaatcaactgcaGactgtaaatttccgacagag	14	11	8	8	1	2	3	1	1	1	2	3	4	3	3	1	0	2	2	1	0	5	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr16:81045655G>A	uc002ffx.2	+	2	901	c.111G>A	c.(109-111)CAG>CAA	p.Q37Q	CENPN_uc002ffw.3_Silent_p.Q37Q|CENPN_uc010vnl.1_Silent_p.Q37Q|CENPN_uc010vnm.1_Silent_p.Q37Q|CENPN_uc002ffy.3_Silent_p.Q37Q	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	37					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						ATCAACTGCAGACTGTAAATT	0.413													37	63					0	0	0	0	A	81045655	A	A	81045655	2	1	23	1	0	0	0	0	0	0	0	1	3253	933	33	2		2	CENPN	16	81045655	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	5466406	81045655	9309098	272	4887											
LRRC50	123872	broad.mit.edu	37	chr16	84211375	84211375	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acacccccagagacgtgtgtCggagttgcccagcccagcca	9	5	11	16	2	0	1	0	0	0	1	1	3	0	2	5	1	3	1	5	1	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr16:84211375C>G	uc002fhl.3	+	12	2287	c.2106C>G	c.(2104-2106)GTC>GTG	p.V702V	LRRC50_uc010vnw.1_Silent_p.V466V	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	702					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						AGACGTGTGTCGGAGTTGCCC	0.577									Kartagener_syndrome				106	154					0	0	0	0	G	84211375	G	G	84211375	2	3	23	1	0	0	0	0	0	0	0	1	9059	871	31	3		3	LRRC50	16	84211375	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	3165720	84211375	6143378	273	4888											
RNMTL1	55178	broad.mit.edu	37	chr17	686565	686566	+	Frame_Shift_Ins	INS	-	G	G																															gtaacgccacaaggaataatINSgggttagtgattacccagtg																										TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:686565_686566insG	uc002frw.2	+	2	663_664	c.557_558insG	c.(556-558)ATGfs	p.M186fs	GLOD4_uc002fru.2_5'Flank|GLOD4_uc010vqc.1_5'Flank|GLOD4_uc002frv.2_5'Flank	NM_018146	NP_060616	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	186					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		CAAGGAATAATGGGTTAGTGAT	0.272													---	---	---								G	686566	G	G	686565	7	5	23	1	0	1	1	0	0	0	0	0	13572	1464	51	0	563	0	RNMTL1	17	686565	Frame_Shift_Ins	INS	-	TCGA-BB-4223-01A-01D-1434-08		686565	80508645	274	4889											
NLRP1	22861	broad.mit.edu	37	chr17	5462809	5462809	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggatgaagagcagccgctCtggcctagacaggatctgtc	10	7	14	10	1	2	3	0	1	2	2	3	6	2	5	2	3	2	2	2	3	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:5462809C>G	uc002gci.2	-	4	1762	c.1207G>C	c.(1207-1209)GAG>CAG	p.E403Q	NLRP1_uc002gcg.1_Missense_Mutation_p.E403Q|NLRP1_uc002gck.2_Missense_Mutation_p.E403Q|NLRP1_uc002gcj.2_Missense_Mutation_p.E403Q|NLRP1_uc002gcl.2_Missense_Mutation_p.E403Q|NLRP1_uc002gch.3_Missense_Mutation_p.E403Q|NLRP1_uc010clh.2_Missense_Mutation_p.E403Q	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	403	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				AGCAGCCGCTCTGGCCTAGAC	0.597													4	95					0	0	0	0	G	5462809	G	G	5462809	3	3	23	1	0	0	0	0	1	0	0	0	10525	922	32	2	3345	2	NLRP1	17	5462809	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	4776244	5462809	75732401	275	4890											
SAT2	112483	broad.mit.edu	37	chr17	7529794	7529795	+	Frame_Shift_Ins	INS	-	TCCT	TCCT																															gccaactttctcgttgcctcINStccttgaaagcagaagaagt																										TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:7529794_7529795insTCCT	uc002gic.2	-	6	724_725	c.483_484insAGGA	c.(481-486)GGAGAGfs	p.G161fs	SHBG_uc010cmo.2_Intron|SHBG_uc010cmp.2_Intron|SHBG_uc010cmq.2_Intron|SHBG_uc010cmr.2_Intron|SHBG_uc010cms.2_Intron|SHBG_uc010cmt.2_Intron|SHBG_uc010cmu.2_Intron|SAT2_uc002gib.1_RNA|SHBG_uc010cmz.2_5'Flank|SHBG_uc010cmv.2_5'Flank|SHBG_uc010cmw.2_5'Flank|SHBG_uc010cmx.2_5'Flank|SHBG_uc010cmy.2_5'Flank|SHBG_uc002gid.3_5'Flank	NM_133491	NP_597998	Q96F10	SAT2_HUMAN	diamine N-acetyltransferase 2	161_162	N-acetyltransferase.					cytoplasm	diamine N-acetyltransferase activity	p.?(1)			0				READ - Rectum adenocarcinoma(115;0.166)	Spermine(DB00127)	CTCGTTGCCTCTCCTTGAAAGC	0.545													---	---	---								TCCT	7529795	TCCT	TCCT	7529794	7	5	23	1	0	1	1	0	0	0	0	0	13917	922	32	0	32	0	SAT2	17	7529794	Frame_Shift_Ins	INS	-	TCGA-BB-4223-01A-01D-1434-08	2066985	7529794	73665416	276	4891											
ATP1B2	482	broad.mit.edu	37	chr17	7557557	7557557	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcactgggcagccctgtgtCttcatcaagatgaaccgggt	9	9	12	11	1	3	2	2	1	1	1	3	2	3	2	2	2	3	2	2	2	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:7557557C>G	uc002gif.1	+	4	1117	c.534C>G	c.(532-534)GTC>GTG	p.V178V		NM_001678	NP_001669	P14415	AT1B2_HUMAN	Na+/K+ -ATPase beta 2 subunit	178	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		AGCCCTGTGTCTTCATCAAGA	0.567													134	249					0	0	0	0	G	7557557	G	G	7557557	2	3	23	1	0	0	0	0	0	0	0	1	1135	900	32	2		2	ATP1B2	17	7557557	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	27763	7557557	73637653	277	4892											
C17orf42	79736	broad.mit.edu	37	chr17	29226242	29226242	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcaatagcttgtaataatGaatcataaagctcttctact	15	13	6	7	0	3	1	1	1	2	0	3	1	3	1	0	1	3	4	0	1	8	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:29226242G>A	uc002hfu.2	-	4	1098	c.1028C>T	c.(1027-1029)TCA>TTA	p.S343L	C17orf42_uc002hfv.2_RNA	NM_024683	NP_078959	Q96QE5	TEFM_HUMAN	hypothetical protein LOC79736	343					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding			ovary(1)	1		all_cancers(10;4.64e-07)|all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				TTGTAATAATGAATCATAAAG	0.363													9	278					0	0	0	0	A	29226242	A	A	29226242	3	1	23	1	0	0	0	0	1	0	0	0	1863	1294	45	2	58	2	C17orf42	17	29226242	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	21668685	29226242	51968968	278	4893											
KRT24	192666	broad.mit.edu	37	chr17	38855880	38855880	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagccacgtagccagcttCtgtgtcagccagggttccct	6	10	11	14	1	2	1	1	1	1	0	3	1	3	1	4	1	4	3	4	1	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:38855880C>T	uc002hvd.2	-	6	1234	c.1177G>A	c.(1177-1179)GAA>AAA	p.E393K		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	393	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				TAGCCAGCTTCTGTGTCAGCC	0.438													14	242					0	0	0	0	T	38855880	T	T	38855880	3	4	23	1	0	0	0	0	1	0	0	0	8500	922	32	2	412	2	KRT24	17	38855880	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	9629638	38855880	42339330	279	4894											
CBX1	10951	broad.mit.edu	37	chr17	46152376	46152376	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggccgactcaccatttcatCaggaacatgagctctccact	10	10	7	14	1	4	1	3	1	1	0	5	3	4	2	3	2	2	1	3	2	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:46152376C>G	uc002ind.3	-	4	886	c.405G>C	c.(403-405)CTG>CTC	p.L135L	CBX1_uc002ine.3_Silent_p.L135L	NM_006807	NP_006798	P83916	CBX1_HUMAN	heterochromatin protein 1-beta	135	Chromo 2; shadow subtype.	PxVxL motif (By similarity).				nuclear heterochromatin|nucleoplasm|spindle	chromatin binding|enzyme binding				0						ACCATTTCATCAGGAACATGA	0.478													11	286					0	0	0	0	G	46152376	G	G	46152376	2	3	23	1	0	0	0	0	0	0	0	1	2729	813	29	2		2	CBX1	17	46152376	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	7296496	46152376	35042834	280	4895											
MTMR4	9110	broad.mit.edu	37	chr17	56573327	56573327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctggtcccttagtctcttCtaggactttgatctcaggat	7	15	9	10	0	3	1	1	1	3	0	6	3	4	3	1	3	1	1	1	3	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:56573327C>T	uc002iwj.2	-	16	2286	c.2176G>A	c.(2176-2178)GAA>AAA	p.E726K		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	726						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTAGTCTCTTCTAGGACTTTG	0.493													31	610					0	0	0	0	T	56573327	T	T	56573327	3	4	23	1	0	0	0	0	1	0	0	0	9999	922	32	2	1427	2	MTMR4	17	56573327	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	10420951	56573327	24621883	281	4896											
PRR11	55771	broad.mit.edu	37	chr17	57270903	57270903	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtggtcaaacatgtcacatGagtggtaaacttacaaatgt	14	12	9	6	0	2	1	2	1	0	0	2	1	2	1	0	2	3	1	0	2	5	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:57270903G>A	uc002ixf.1	+	5	532	c.453G>A	c.(451-453)ATG>ATA	p.M151I	PRR11_uc002ixg.1_RNA	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	proline rich 11	151										ovary(2)	2	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CATGTCACATGAGTGGTAAAC	0.453													7	138					0	0	0	0	A	57270903	A	A	57270903	3	1	23	1	0	0	0	0	1	0	0	0	12645	1290	45	2	467	2	PRR11	17	57270903	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	697576	57270903	23924307	282	4897											
AXIN2	8313	broad.mit.edu	37	chr17	63532463	63532463	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttgggggcttcgacacctCagctagcctgcgacaggcct	6	9	12	14	2	1	0	1	0	0	0	2	2	1	0	3	3	3	2	3	3	1	3	rs121908567		TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:63532463C>T	uc002jfi.2	-	8	2405	c.2116G>A	c.(2116-2118)GAG>AAG	p.E706K	AXIN2_uc002jfh.2_Missense_Mutation_p.E641K	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	706					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						TTCGACACCTCAGCTAGCCTG	0.642									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				3	24					0	0	0	0	T	63532463	T	T	63532463	3	4	23	1	0	0	0	0	1	0	0	0	1239	835	29	2	431	2	AXIN2	17	63532463	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	6261560	63532463	17662747	283	4898											
QRICH2	84074	broad.mit.edu	37	chr17	74287166	74287166	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctcctcatccagatccttCatactctcctttagccccac	7	13	3	18	0	3	1	2	0	1	1	7	1	6	1	6	0	3	1	6	0	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:74287166C>T	uc002jrd.1	-	4	3324	c.3144G>A	c.(3142-3144)ATG>ATA	p.M1048I	QRICH2_uc010wsz.1_Missense_Mutation_p.M974I|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1048							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						CCAGATCCTTCATACTCTCCT	0.532													8	195					0	0	0	0	T	74287166	T	T	74287166	3	4	23	1	0	0	0	0	1	0	0	0	12945	826	29	2	1911	2	QRICH2	17	74287166	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	10754703	74287166	6908044	284	4899											
JMJD6	23210	broad.mit.edu	37	chr17	74721741	74721741	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttcatcttcatcttcactGagtagccatcgttatcctca	9	16	4	12	1	6	1	4	1	2	0	8	1	7	1	2	0	1	2	2	0	2	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:74721741G>A	uc002jso.2	-	2	650	c.326C>T	c.(325-327)TCA>TTA	p.S109L	JMJD6_uc002jsn.1_Missense_Mutation_p.S109L|JMJD6_uc010dgz.2_Missense_Mutation_p.S109L|C17orf95_uc002jsp.2_5'Flank|C17orf95_uc002jsq.2_5'Flank|C17orf95_uc002jsr.2_5'Flank|C17orf95_uc002jss.2_5'Flank|C17orf95_uc002jst.2_5'Flank|C17orf95_uc002jsu.2_5'Flank	NM_015167	NP_055982	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6 isoform 2	109					mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			skin(2)|ovary(1)	3						CATCTTCACTGAGTAGCCATC	0.463													11	262					0	0	0	0	A	74721741	A	A	74721741	3	1	23	1	0	0	0	0	1	0	0	0	7992	1294	45	2	946	2	JMJD6	17	74721741	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	434575	74721741	6473469	285	4900											
JMJD6	23210	broad.mit.edu	37	chr17	74721784	74721784	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acacttgaacttctggttccGatatttcctttttaggcgct	7	17	7	10	2	1	1	0	1	1	0	3	2	3	1	2	2	1	2	2	2	3	8			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:74721784G>C	uc002jso.2	-	2	607	c.283C>G	c.(283-285)CGG>GGG	p.R95G	JMJD6_uc002jsn.1_Missense_Mutation_p.R95G|JMJD6_uc010dgz.2_Missense_Mutation_p.R95G|C17orf95_uc002jsp.2_5'Flank|C17orf95_uc002jsq.2_5'Flank|C17orf95_uc002jsr.2_5'Flank|C17orf95_uc002jss.2_5'Flank|C17orf95_uc002jst.2_5'Flank|C17orf95_uc002jsu.2_5'Flank	NM_015167	NP_055982	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6 isoform 2	95	Nuclear localization signal 2.				mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			skin(2)|ovary(1)	3						TTCTGGTTCCGATATTTCCTT	0.473													10	241					0	0	0	0	C	74721784	C	C	74721784	3	2	23	1	0	0	0	0	1	0	0	0	7992	1057	37	3	989	3	JMJD6	17	74721784	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	43	74721784	6473426	286	4901											
DNAH17	8632	broad.mit.edu	37	chr17	76459075	76459075	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgtagttgtagcgcctctCagtagccaggtataccctgg	7	11	13	10	1	1	0	1	0	1	0	2	0	1	0	3	3	3	5	3	3	5	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:76459075C>G	uc010dhp.1	-	2	247	c.25G>C	c.(25-27)GAG>CAG	p.E9Q	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TAGCGCCTCTCAGTAGCCAGG	0.498													9	97					0	0	0	0	G	76459075	G	G	76459075	3	3	23	1	0	0	0	0	1	0	0	0	4623	835	29	2	4463	2	DNAH17	17	76459075	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1737291	76459075	4736135	287	4902											
GAA	2548	broad.mit.edu	37	chr17	78092121	78092121	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctggaagtgctggagcgaGgggcctacacacaggtcatc	9	6	15	11	1	1	0	1	0	0	0	2	3	1	2	2	5	3	1	2	5	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr17:78092121G>C	uc002jxo.2	+	19	2793	c.2611G>C	c.(2611-2613)GGG>CGG	p.G871R	GAA_uc002jxp.2_Missense_Mutation_p.G871R|GAA_uc002jxq.2_Missense_Mutation_p.G871R	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	871					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GCTGGAGCGAGGGGCCTACAC	0.677													7	165					0	0	0	0	C	78092121	C	C	78092121	3	2	23	1	0	0	0	0	1	0	0	0	6181	1000	35	4	2677	4	GAA	17	78092121	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1633046	78092121	3103089	288	4903											
CETN1	1068	broad.mit.edu	37	chr18	580886	580886	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggacggcgaagtgaacgagGaggagttccttcggatcatg	10	7	17	7	4	1	1	1	1	0	0	3	7	2	5	1	5	1	1	1	5	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr18:580886G>T	uc002kko.1	+	1	520	c.478G>T	c.(478-480)GAG>TAG	p.E160*		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	160	2 (Probable).|EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2						AGTGAACGAGGAGGAGTTCCT	0.537													27	117					1.04121e-07	1.08055e-07	1	0	T	580886	T	T	580886	4	4	23	1	0	0	0	0	0	1	0	0	3289	1175	41	2	480	2	CETN1	18	580886	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08		580886	77496362	289	4904											
DLGAP1	9229	broad.mit.edu	37	chr18	3879505	3879505	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgggccttgggctccgcGcgccgctccttgctcttgct	0	10	14	17	5	1	0	0	0	1	0	3	0	3	0	5	3	2	4	5	3	0	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr18:3879505G>A	uc002kmf.2	-	1	631	c.564C>T	c.(562-564)CGC>CGT	p.R188R	DLGAP1_uc010wyz.1_Silent_p.R188R|DLGAP1_uc002kmk.2_Silent_p.R188R|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	188					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane		p.R188C(1)		ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				TGGGCTCCGCGCGCCGCTCCT	0.706													110	399					0	0	0	0	A	3879505	A	A	3879505	2	1	23	1	0	0	0	0	0	0	0	1	4581	1074	38	1		1	DLGAP1	18	3879505	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3298619	3879505	74197743	290	4905											
KIAA0802	23255	broad.mit.edu	37	chr18	8825033	8825033	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagcccagagcactgccaGaagcagccactgcggagcca	12	2	11	16	1	0	2	0	0	0	2	0	3	0	3	5	1	7	2	5	1	1	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr18:8825033G>C	uc002knr.2	+	15	3667	c.3525G>C	c.(3523-3525)CAG>CAC	p.Q1175H	KIAA0802_uc002knq.2_Missense_Mutation_p.Q1134H|KIAA0802_uc002kns.2_Missense_Mutation_p.Q515H	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1485											0						AGCACTGCCAGAAGCAGCCAC	0.647													4	135					0	0	0	0	C	8825033	C	C	8825033	3	2	23	1	0	0	0	0	1	0	0	0	8233	933	33	2	3575	2	KIAA0802	18	8825033	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4945528	8825033	69252215	291	4906											
ATP8B1	5205	broad.mit.edu	37	chr18	55398973	55398973	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtttcatcatcactgtaggGaaccacttcgtcattaggct	9	14	8	10	1	4	0	4	0	0	0	5	1	4	1	1	2	1	3	1	2	3	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr18:55398973G>A	uc002lgw.2	-	1	67	c.67C>T	c.(67-69)CCC>TCC	p.P23S	uc002lgv.1_RNA	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	23	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				TCACTGTAGGGAACCACTTCG	0.463									Byler_disease				13	735					0	0	0	0	A	55398973	A	A	55398973	3	1	23	1	0	0	0	0	1	0	0	0	1196	1174	41	2	3796	2	ATP8B1	18	55398973	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	46573940	55398973	22678275	292	4907											
MALT1	10892	broad.mit.edu	37	chr18	56411652	56411652	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgagttttccaatgtcatGatcatctatacaagtatagt	12	15	7	7	0	3	2	2	2	1	0	4	2	4	2	1	0	1	3	1	0	6	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr18:56411652G>C	uc002lhm.1	+	15	2094	c.1836G>C	c.(1834-1836)ATG>ATC	p.M612I	MALT1_uc002lhn.1_Missense_Mutation_p.M601I	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	612					activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						CCAATGTCATGATCATCTATA	0.338			T	BIRC3	MALT								6	355					0	0	0	0	C	56411652	C	C	56411652	3	2	23	1	0	0	0	0	1	0	0	0	9255	1290	45	2	1894	2	MALT1	18	56411652	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1012679	56411652	21665596	293	4908											
CNDP2	55748	broad.mit.edu	37	chr18	72180810	72180810	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaggctctttggtggacaaGagggggaacatcctgatccc	9	9	13	10	0	2	2	1	1	1	1	4	4	4	4	2	5	1	1	2	5	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr18:72180810G>A	uc002llm.1	+	8	921	c.759G>A	c.(757-759)AAG>AAA	p.K253K	CNDP2_uc002lln.1_Silent_p.K169K|CNDP2_uc010dqs.2_Intron	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	253						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		TGGTGGACAAGAGGGGGAACA	0.607													22	93					0	0	0	0	A	72180810	A	A	72180810	2	1	23	1	0	0	0	0	0	0	0	1	3609	933	33	2		2	CNDP2	18	72180810	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	15769158	72180810	5896438	294	4909											
SALL3	27164	broad.mit.edu	37	chr18	76753093	76753093	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcttctacctcagacttccGccagcggcgtcatcttcccc	5	10	7	19	4	4	1	2	0	2	1	6	1	6	1	5	1	2	1	5	1	1	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr18:76753093G>A	uc002lmt.2	+	2	1102	c.1102G>A	c.(1102-1104)GCC>ACC	p.A368T	SALL3_uc010dra.2_5'UTR	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	368					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TCAGACTTCCGCCAGCGGCGT	0.716													4	53					0	0	0	0	A	76753093	A	A	76753093	3	1	23	1	0	0	0	0	1	0	0	0	13877	1087	38	1	1108	1	SALL3	18	76753093	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	4572283	76753093	1324155	295	4910											
JSRP1	126306	broad.mit.edu	37	chr19	2254199	2254199	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacccactcgctccggctttCagcctctccttccccgttcc	4	11	5	21	3	2	0	1	0	1	0	7	0	5	0	7	1	2	3	7	1	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:2254199C>T	uc002lvi.1	-	3	284	c.249G>A	c.(247-249)CTG>CTA	p.L83L	JSRP1_uc002lvj.1_Silent_p.L83L	NM_144616	NP_653217	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	83						sarcoplasmic reticulum membrane				pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCGGCTTTCAGCCTCTCCT	0.632											OREG0025137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	531					0	0	0	0	T	2254199	T	T	2254199	2	4	23	1	0	0	0	0	0	0	0	1	8005	813	29	2		2	JSRP1	19	2254199	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08		2254199	56874784	296	4911											
LONP1	9361	broad.mit.edu	37	chr19	5711832	5711832	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtggacaacgttctctacctCcaccatgagcacctcagccg	9	8	8	16	2	2	1	1	1	1	0	4	2	3	2	5	1	4	2	5	1	2	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:5711832C>G	uc002mcx.2	-	4	853	c.820G>C	c.(820-822)GAG>CAG	p.E274Q	LONP1_uc002mcy.2_Missense_Mutation_p.E210Q|LONP1_uc010duh.2_Missense_Mutation_p.E15Q|LONP1_uc010dui.2_Missense_Mutation_p.E274Q|LONP1_uc002mcz.2_Missense_Mutation_p.E78Q	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	274	Lon.				cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						TTCTCTACCTCCACCATGAGC	0.682													8	271					0	0	0	0	G	5711832	G	G	5711832	3	3	23	1	0	0	0	0	1	0	0	0	8942	864	30	2	2119	2	LONP1	19	5711832	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	3457633	5711832	53417151	297	4912											
TRIP10	9322	broad.mit.edu	37	chr19	6743836	6743836	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctatttttcacagatgcccCagatattcgatgtgagtgct	9	15	8	9	1	2	3	1	1	1	2	3	4	2	3	2	0	2	1	2	0	2	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:6743836C>T	uc002mfs.2	+	7	697	c.631C>T	c.(631-633)CAG>TAG	p.Q211*	TRIP10_uc010dux.1_Nonsense_Mutation_p.Q211*|TRIP10_uc002mfr.2_Nonsense_Mutation_p.Q211*|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Nonsense_Mutation_p.Q30*	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	211	Induction of membrane tubulation.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						ACAGATGCCCCAGATATTCGA	0.498													8	224					0	0	0	0	T	6743836	T	T	6743836	4	4	23	1	0	0	0	0	0	1	0	0	16621	595	21	4	657	4	TRIP10	19	6743836	Nonsense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1032004	6743836	52385147	298	4913											
FBN3	84467	broad.mit.edu	37	chr19	8138080	8138080	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagcccccgagggcctgatCaaagtcaaagccagaggggc	11	3	14	13	1	2	2	2	1	0	1	2	3	2	2	4	3	2	1	4	3	2	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:8138080C>G	uc002mjf.2	-	61	7825	c.7804G>C	c.(7804-7806)GAT>CAT	p.D2602H	FBN3_uc002mje.2_Missense_Mutation_p.D398H	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2602	EGF-like 43; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						AGGGCCTGATCAAAGTCAAAG	0.662													58	154					0	0	0	0	G	8138080	G	G	8138080	3	3	23	1	0	0	0	0	1	0	0	0	5736	826	29	2	637	2	FBN3	19	8138080	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1394244	8138080	50990903	299	4914											
EIF3G	8666	broad.mit.edu	37	chr19	10227615	10227615	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcggcaggacacgatcttCtggcccttgagtttgttcat	7	13	11	10	2	3	1	1	1	2	0	3	3	3	2	1	3	1	3	1	3	0	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:10227615C>T	uc002mnd.2	-	7	520	c.456G>A	c.(454-456)CAG>CAA	p.Q152Q		NM_003755	NP_003746	O75821	EIF3G_HUMAN	eukaryotic translation initiation factor 3,	152						cytosol|eukaryotic translation initiation factor 3 complex|nucleus|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0			OV - Ovarian serous cystadenocarcinoma(20;3.53e-09)|Epithelial(33;4.91e-06)|all cancers(31;1.1e-05)			ACACGATCTTCTGGCCCTTGA	0.647													11	294					0	0	0	0	T	10227615	T	T	10227615	2	4	23	1	0	0	0	0	0	0	0	1	5041	912	32	2		2	EIF3G	19	10227615	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	2089535	10227615	48901368	300	4915											
DNMT1	1786	broad.mit.edu	37	chr19	10265371	10265371	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtcataactctccacctgctCcaccacaaactgcgcgtgtc	9	9	6	17	2	2	0	1	0	1	0	5	0	3	0	4	0	4	1	4	0	2	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:10265371C>G	uc002mng.2	-	20	1855	c.1675G>C	c.(1675-1677)GAG>CAG	p.E559Q	DNMT1_uc010xlc.1_Missense_Mutation_p.E575Q|DNMT1_uc002mnh.2_Missense_Mutation_p.E454Q|DNMT1_uc010xld.1_Missense_Mutation_p.E559Q	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	559	Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TCCACCTGCTCCACCACAAAC	0.582													4	128					0	0	0	0	G	10265371	G	G	10265371	3	3	23	1	0	0	0	0	1	0	0	0	4697	864	30	2	3259	2	DNMT1	19	10265371	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	37756	10265371	48863612	301	4916											
ZNF563	147837	broad.mit.edu	37	chr19	12430300	12430300	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcttcgaaggtttctacgaGaactgaaggtttttccacat	10	14	9	8	2	2	2	0	1	2	1	4	4	3	2	1	2	2	2	1	2	4	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:12430300G>C	uc002mtp.2	-	4	777	c.539C>G	c.(538-540)TCT>TGT	p.S180C	ZNF563_uc002mtq.2_Missense_Mutation_p.S180C	NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	180	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTTTCTACGAGAACTGAAGGT	0.433													8	359					0	0	0	0	C	12430300	C	C	12430300	3	2	23	1	0	0	0	0	1	0	0	0	18061	942	33	2	895	2	ZNF563	19	12430300	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	2164929	12430300	46698683	302	4917											
ZSWIM4	65249	broad.mit.edu	37	chr19	13941729	13941729	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tatggggatttcatcgaattCctgggcaaggcccgggagac	9	9	14	9	2	1	1	1	0	0	1	3	4	2	2	2	5	0	1	2	5	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:13941729C>G	uc002mxh.1	+	13	3024	c.2835C>G	c.(2833-2835)TTC>TTG	p.F945L	ZSWIM4_uc010xng.1_Missense_Mutation_p.F868L	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	945							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			TCATCGAATTCCTGGGCAAGG	0.612													7	209					0	0	0	0	G	13941729	G	G	13941729	3	3	23	1	0	0	0	0	1	0	0	0	18310	854	30	2	2885	2	ZSWIM4	19	13941729	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1511429	13941729	45187254	303	4918											
TECR	9524	broad.mit.edu	37	chr19	14675667	14675667	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atcaccctctctacactcccCctagtaagtggcctcagacc	9	9	5	18	0	3	1	2	0	1	1	5	1	4	1	5	1	1	1	5	1	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:14675667C>T	uc002mza.2	+	8	686	c.559C>T	c.(559-561)CCT>TCT	p.P187S	TECR_uc002mzb.2_Missense_Mutation_p.P202S|TECR_uc010xns.1_Missense_Mutation_p.P32S|TECR_uc002mzc.2_Missense_Mutation_p.P32S|TECR_uc002mzd.2_Missense_Mutation_p.P187S|TECR_uc002mze.2_Missense_Mutation_p.P13S|TECR_uc002mzf.1_5'Flank	NM_138501	NP_612510	Q9NZ01	TECR_HUMAN	glycoprotein, synaptic 2	187					fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity				0						CTACACTCCCCCTAGTAAGTG	0.617													9	189					0	0	0	0	T	14675667	T	T	14675667	3	4	23	1	0	0	0	0	1	0	0	0	15811	623	22	4	589	4	TECR	19	14675667	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	733938	14675667	44453316	304	4919											
ILVBL	10994	broad.mit.edu	37	chr19	15233935	15233935	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggactgggtacctgcagcaGagtgctggcagccccaccca	9	5	13	14	0	0	1	0	0	0	1	0	2	0	2	4	3	5	5	4	3	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:15233935G>C	uc002nam.2	-	4	578	c.457C>G	c.(457-459)CTG>GTG	p.L153V	ILVBL_uc010dzw.2_Missense_Mutation_p.L46V|ILVBL_uc010dzx.1_Missense_Mutation_p.L153V	NM_006844	NP_006835	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	153						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			ovary(2)	2						ACCTGCAGCAGAGTGCTGGCA	0.627													9	224					0	0	0	0	C	15233935	C	C	15233935	3	2	23	1	0	0	0	0	1	0	0	0	7754	933	33	2	1493	2	ILVBL	19	15233935	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	558268	15233935	43895048	305	4920											
BRD4	23476	broad.mit.edu	37	chr19	15375245	15375245	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcatgtccatggggtgcttGatgatgtcacagtagtcgtg	7	13	13	8	1	2	2	2	2	0	0	4	2	3	2	1	2	1	2	1	2	1	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:15375245G>C	uc002nar.2	-	6	1404	c.1182C>G	c.(1180-1182)ATC>ATG	p.I394M	BRD4_uc002nas.2_Missense_Mutation_p.I394M|BRD4_uc002nat.3_Missense_Mutation_p.I394M|BRD4_uc002nau.3_Missense_Mutation_p.I394M	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	394	Bromo 2.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TGGGGTGCTTGATGATGTCAC	0.567			T	NUT|C15orf55	lethal midline carcinoma of young people						OREG0025319	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	351					0	0	0	0	C	15375245	C	C	15375245	3	2	23	1	0	0	0	0	1	0	0	0	1509	1280	45	2	2981	2	BRD4	19	15375245	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	141310	15375245	43753738	306	4921											
CILP2	148113	broad.mit.edu	37	chr19	19656685	19656685	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgggagccaccggccggaCgacccagcctcttccagagg	7	3	14	17	4	1	1	0	0	1	1	2	4	2	3	7	4	2	0	7	4	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:19656685C>T	uc002nmv.3	+	8	3416	c.3331C>T	c.(3331-3333)CGA>TGA	p.R1111*	CILP2_uc002nmw.3_Nonsense_Mutation_p.R1117*	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1111						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						ACCGGCCGGACGACCCAGCCT	0.672													5	16					0	0	0	0	T	19656685	T	T	19656685	4	4	23	1	0	0	0	0	0	1	0	0	3445	528	19	1	3361	1	CILP2	19	19656685	Nonsense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	4281440	19656685	39472298	307	4922											
ZNF91	7644	broad.mit.edu	37	chr19	23544861	23544861	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttatgtttagcaagggttGaagaatggctaaaagctttg	12	14	11	4	0	1	2	0	1	1	1	1	2	1	2	0	2	2	5	0	2	7	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:23544861G>A	uc002nre.2	-	4	1033	c.920C>T	c.(919-921)TCA>TTA	p.S307L	ZNF91_uc010xrj.1_Missense_Mutation_p.S275L	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	307	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGCAAGGGTTGAAGAATGGCT	0.403													10	296					0	0	0	0	A	23544861	A	A	23544861	3	1	23	1	0	0	0	0	1	0	0	0	18267	1294	45	2	2659	2	ZNF91	19	23544861	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	3888176	23544861	35584122	308	4923											
MAG	4099	broad.mit.edu	37	chr19	35786781	35786781	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaaactgcaccctcctgctCagcaacgtcagccccgagct	9	6	8	18	3	2	0	2	0	0	0	3	2	3	0	4	0	7	4	4	0	2	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:35786781C>G	uc002nyy.1	+	4	461	c.312C>G	c.(310-312)CTC>CTG	p.L104L	MAG_uc002nyx.1_Silent_p.L104L|MAG_uc010eds.1_Silent_p.L79L|MAG_uc002nyz.1_Silent_p.L104L	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	104	Ig-like V-type.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCCTCCTGCTCAGCAACGTCA	0.642													10	562					0	0	0	0	G	35786781	G	G	35786781	2	3	23	1	0	0	0	0	0	0	0	1	9213	813	29	2		2	MAG	19	35786781	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	12241920	35786781	23342202	309	4924											
CAPNS1	826	broad.mit.edu	37	chr19	36637120	36637120	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccacctgaatgagcatctCtataacatgatcatccgacg	12	11	6	12	2	2	3	1	3	1	0	5	4	4	3	3	0	2	1	3	0	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:36637120C>A	uc002odj.2	+	9	784	c.627C>A	c.(625-627)CTC>CTA	p.L209L	CAPNS1_uc002odi.1_Silent_p.L209L|CAPNS1_uc002odk.2_Silent_p.L209L|CAPNS1_uc002odl.2_Silent_p.L209L	NM_001749	NP_001740	P04632	CPNS1_HUMAN	calpain, small subunit 1	209	EF-hand 4.				positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			ATGAGCATCTCTATAACATGA	0.537													9	619					0.000442599	0.000451364	1	0	A	36637120	A	A	36637120	2	1	23	1	0	0	0	0	0	0	0	1	2645	900	32	2		2	CAPNS1	19	36637120	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	850339	36637120	22491863	310	4925											
PLEKHG2	64857	broad.mit.edu	37	chr19	39914871	39914871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgttctgatttcacagtttCagtcaccacccctgtgccca	7	14	6	14	0	4	1	3	1	1	0	4	1	4	1	4	0	1	2	4	0	0	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:39914871C>T	uc010xuz.1	+	19	3423	c.3098C>T	c.(3097-3099)TCA>TTA	p.S1033L	PLEKHG2_uc010xuy.1_Missense_Mutation_p.S974L|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.S811L	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	1033					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TTCACAGTTTCAGTCACCACC	0.547													10	292					0	0	0	0	T	39914871	T	T	39914871	3	4	23	1	0	0	0	0	1	0	0	0	12124	838	29	2	3168	2	PLEKHG2	19	39914871	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	3277751	39914871	19214112	311	4926											
SNRPD2	6633	broad.mit.edu	37	chr19	46190931	46190931	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttcttgcccttgccactCttgggtacctcagtccacat	5	15	6	15	0	4	0	1	0	3	0	5	0	5	0	4	1	3	1	4	1	1	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:46190931C>G	uc002pcw.2	-	3	534	c.237G>C	c.(235-237)AAG>AAC	p.K79N	SNRPD2_uc002pcv.2_Missense_Mutation_p.K69N	NM_004597	NP_004588	P62316	SMD2_HUMAN	small nuclear ribonucleoprotein D2 isoform 1	79					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00546)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.194)		CCTTGCCACTCTTGGGTACCT	0.597													5	208					0	0	0	0	G	46190931	G	G	46190931	3	3	23	1	0	0	0	0	1	0	0	0	14929	912	32	2	123	2	SNRPD2	19	46190931	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	6276060	46190931	12938052	312	4927											
IRF2BP1	26145	broad.mit.edu	37	chr19	46387755	46387755	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggcttcggccacattcttCagggcggcaatgggcgaggg	7	7	17	10	3	2	0	1	0	1	0	3	1	2	0	1	6	0	2	1	6	1	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:46387755C>T	uc002pds.1	-	1	1622	c.1278G>A	c.(1276-1278)CTG>CTA	p.L426L		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	426					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CCACATTCTTCAGGGCGGCAA	0.716													4	114					0	0	0	0	T	46387755	T	T	46387755	2	4	23	1	0	0	0	0	0	0	0	1	7868	813	29	2		2	IRF2BP1	19	46387755	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	196824	46387755	12741228	313	4928											
IGFL3	388555	broad.mit.edu	37	chr19	46627533	46627533	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcctgtccttacctgtagttCcttttgaacactggaggagg	7	14	10	10	0	0	1	0	1	0	0	3	3	3	3	4	3	2	2	4	3	3	5	rs148630126		TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:46627533C>T	uc002pea.1	-	2	96	c.71G>A	c.(70-72)GGA>GAA	p.G24E		NM_207393	NP_997276	Q6UXB1	IGFL3_HUMAN	IGF-like family member 3 precursor	24						extracellular region	protein binding				0		Ovarian(192;0.0175)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00473)|GBM - Glioblastoma multiforme(486;0.0149)|Epithelial(262;0.239)		ACCTGTAGTTCCTTTTGAACA	0.453													8	125					0	0	0	0	T	46627533	T	T	46627533	3	4	23	1	0	0	0	0	1	0	0	0	7627	855	30	2	318	2	IGFL3	19	46627533	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	239778	46627533	12501450	314	4929											
SLC8A2	6543	broad.mit.edu	37	chr19	47951487	47951487	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttgaacaccagcgtgccctCgctgcggcggggtggggagg	5	7	18	11	4	0	1	0	1	0	0	1	2	0	2	2	6	4	1	2	6	1	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:47951487C>G	uc002pgx.2	-	4	1620	c.1342G>C	c.(1342-1344)GAG>CAG	p.E448Q	SLC8A2_uc010xyq.1_Missense_Mutation_p.E204Q|SLC8A2_uc010xyr.1_Intron|SLC8A2_uc010ele.2_Missense_Mutation_p.E448Q	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	448	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		AGCGTGCCCTCGCTGCGGCGG	0.637													5	104					0	0	0	0	G	47951487	G	G	47951487	3	3	23	1	0	0	0	0	1	0	0	0	14771	898	31	3	1451	3	SLC8A2	19	47951487	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1323954	47951487	11177496	315	4930											
CRX	1406	broad.mit.edu	37	chr19	48342644	48342644	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagaaacagcagcagcagcCcccagggggccaggccaagg	12	0	15	14	0	0	1	0	0	0	1	0	1	0	1	4	4	5	4	4	4	2	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:48342644C>G	uc002phq.3	+	4	524	c.320C>G	c.(319-321)CCC>CGC	p.P107R		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	107					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		cagcagcagcCCCCAGGGGGC	0.517													11	268					0	0	0	0	G	48342644	G	G	48342644	3	3	23	1	0	0	0	0	1	0	0	0	3917	623	22	4	330	4	CRX	19	48342644	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	391157	48342644	10786339	316	4931											
LMTK3	114783	broad.mit.edu	37	chr19	49001313	49001313	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatctcaggcccccattctCtgacaccttgtcctcgctct	6	12	6	17	1	3	1	1	1	3	0	7	2	4	1	4	1	0	1	4	1	1	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:49001313C>T	uc002pjk.2	-	12	3100	c.3100G>A	c.(3100-3102)GAG>AAG	p.E1034K		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CCCCCATTCTCTGACACCTTG	0.647													10	365					0	0	0	0	T	49001313	T	T	49001313	3	4	23	1	0	0	0	0	1	0	0	0	8902	922	32	2	1389	2	LMTK3	19	49001313	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	658669	49001313	10127670	317	4932											
LMTK3	114783	broad.mit.edu	37	chr19	49001325	49001325	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccattctctgacaccttgtCctcgctctttgggggtgtca	4	14	9	14	1	3	1	1	1	2	0	6	1	4	1	3	2	0	1	3	2	0	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:49001325C>T	uc002pjk.2	-	12	3088	c.3088G>A	c.(3088-3090)GAC>AAC	p.D1030N		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GACACCTTGTCCTCGCTCTTT	0.642													9	428					0	0	0	0	T	49001325	T	T	49001325	3	4	23	1	0	0	0	0	1	0	0	0	8902	855	30	2	1401	2	LMTK3	19	49001325	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	12	49001325	10127658	318	4933											
PPFIA3	8541	broad.mit.edu	37	chr19	49636556	49636556	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccaagcagaagctgcagcaGacgctgcagaaagcggagac	14	2	14	11	2	0	4	0	0	0	4	0	5	0	4	1	1	6	6	1	1	3	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:49636556G>C	uc002pmr.2	+	9	1421	c.1089G>C	c.(1087-1089)CAG>CAC	p.Q363H	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010emt.2_Missense_Mutation_p.Q287H|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Missense_Mutation_p.Q231H	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	363	Potential.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		AGCTGCAGCAGACGCTGCAGA	0.682													6	118					0	0	0	0	C	49636556	C	C	49636556	3	2	23	1	0	0	0	0	1	0	0	0	12366	933	33	2	1119	2	PPFIA3	19	49636556	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	635231	49636556	9492427	319	4934											
HRC	3270	broad.mit.edu	37	chr19	49658238	49658238	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcctccttttcacggtctGggtggctccagaaatgatgc	7	12	10	12	1	2	2	1	1	1	1	5	2	5	2	3	3	1	1	3	3	1	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:49658238G>C	uc002pmv.2	-	1	444	c.257C>G	c.(256-258)CCA>CGA	p.P86R	TRPM4_uc002pmw.2_5'Flank|TRPM4_uc010emu.2_5'Flank|TRPM4_uc010yak.1_5'Flank|TRPM4_uc002pmx.2_5'Flank|TRPM4_uc010emv.2_5'Flank|TRPM4_uc010yal.1_5'Flank	NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	86					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		TTCACGGTCTGGGTGGCTCCA	0.537													13	344					0	0	0	0	C	49658238	C	C	49658238	3	2	23	1	0	0	0	0	1	0	0	0	7391	1348	47	4	1866	4	HRC	19	49658238	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	21682	49658238	9470745	320	4935											
KLK9	284366	broad.mit.edu	37	chr19	51506440	51506440	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agactgcggggcgccggggtCtggagcagggctcagcaccc	6	4	18	13	3	2	1	1	0	1	1	2	2	2	2	2	6	3	3	2	6	0	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:51506440C>T	uc002pux.1	-	5	767	c.680G>A	c.(679-681)AGA>AAA	p.R227K	KLK9_uc002puw.1_RNA|KLK9_uc010eol.1_Missense_Mutation_p.R198K|KLK8_uc002puq.1_5'Flank|KLK8_uc002pur.1_5'Flank|KLK8_uc002pus.1_5'Flank|KLK8_uc002put.1_5'Flank|KLK8_uc002puu.1_5'UTR|KLK9_uc002puv.1_RNA	NM_012315	NP_036447	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9 precursor	227	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		GCGCCGGGGTCTGGAGCAGGG	0.642													96	219					0	0	0	0	T	51506440	T	T	51506440	3	4	23	1	0	0	0	0	1	0	0	0	8450	913	32	2	76	2	KLK9	19	51506440	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	1848202	51506440	7622543	321	4936											
SIGLEC8	27181	broad.mit.edu	37	chr19	51955701	51955701	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgagtctctgcagtttctcGcttgtggatcttgatctccg	4	16	10	11	2	4	2	0	2	4	0	7	3	4	3	1	1	1	3	1	1	0	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:51955701G>A	uc002pwt.2	-	7	1499	c.1432C>T	c.(1432-1434)CGA>TGA	p.R478*	SIGLEC8_uc010yda.1_Nonsense_Mutation_p.R369*|SIGLEC8_uc002pwu.2_Intron|SIGLEC8_uc010eox.2_Nonsense_Mutation_p.R385*	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	478	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GCAGTTTCTCGCTTGTGGATC	0.483													73	255					0	0	0	0	A	51955701	A	A	51955701	4	1	23	1	0	0	0	0	0	1	0	0	14379	1095	38	1	71	1	SIGLEC8	19	51955701	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	449261	51955701	7173282	322	4937											
SIGLEC6	946	broad.mit.edu	37	chr19	52033951	52033951	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcacaggagacattgagctgGatggttctctccatggtcac	9	11	11	10	0	3	2	2	1	1	1	5	4	4	3	1	4	1	2	1	4	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:52033951G>C	uc002pwy.2	-	3	852	c.690C>G	c.(688-690)ATC>ATG	p.I230M	SIGLEC6_uc002pwz.2_Missense_Mutation_p.I230M|SIGLEC6_uc002pxa.2_Missense_Mutation_p.I230M|SIGLEC6_uc010ydb.1_Missense_Mutation_p.I183M|SIGLEC6_uc010ydc.1_Missense_Mutation_p.I219M|SIGLEC6_uc010eoz.1_Missense_Mutation_p.I208M|SIGLEC6_uc010epb.1_Missense_Mutation_p.I183M|SIGLEC6_uc010epa.1_Missense_Mutation_p.I219M	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	230	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CATTGAGCTGGATGGTTCTCT	0.637													9	272					0	0	0	0	C	52033951	C	C	52033951	3	2	23	1	0	0	0	0	1	0	0	0	14377	1164	41	2	728	2	SIGLEC6	19	52033951	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	78250	52033951	7095032	323	4938											
ZNF480	147657	broad.mit.edu	37	chr19	52825764	52825764	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcacgacatcgaagaattCatactggagagaagccttac	14	9	9	9	2	1	2	1	0	0	2	2	6	1	3	1	1	4	1	1	1	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr19:52825764C>G	uc010ydl.1	+	5	1331	c.1261C>G	c.(1261-1263)CAT>GAT	p.H421D	ZNF480_uc002pyv.2_Missense_Mutation_p.H344D|ZNF480_uc010ydm.1_Missense_Mutation_p.H378D|ZNF480_uc010epn.2_Missense_Mutation_p.H252D|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	421	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		TCGAAGAATTCATACTGGAGA	0.373													9	236					0	0	0	0	G	52825764	G	G	52825764	3	3	23	1	0	0	0	0	1	0	0	0	18002	826	29	2	1275	2	ZNF480	19	52825764	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	791813	52825764	6303219	324	4939											
FAM113A	64773	broad.mit.edu	37	chr20	2820550	2820550	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctcctcgctcgacagacaGaagaccatgccgccaccagc	10	4	10	17	3	0	3	0	0	0	3	3	4	1	3	5	1	2	2	5	1	1	0	rs143418384		TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr20:2820550G>A	uc002wgz.1	-	2	506	c.9C>T	c.(7-9)TTC>TTT	p.F3F	FAM113A_uc002whb.1_5'UTR|FAM113A_uc002wha.1_5'UTR|FAM113A_uc010zqa.1_5'UTR|FAM113A_uc002whc.1_Silent_p.F3F|VPS16_uc002whe.2_5'Flank|VPS16_uc002whf.2_5'Flank|VPS16_uc002whd.2_5'Flank	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773	3							hydrolase activity|protein binding			ovary(2)	2						TCGACAGACAGAAGACCATGC	0.647													15	32					0	0	0	0	A	2820550	A	A	2820550	2	1	23	1	0	0	0	0	0	0	0	1	5429	933	33	2		2	FAM113A	20	2820550	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08		2820550	60204970	325	4940											
UBOX5	22888	broad.mit.edu	37	chr20	3102039	3102039	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgaattacctgtcgagcAgtccatatgtgtcaggctgg	8	12	12	9	1	1	1	1	1	0	0	3	2	2	1	2	2	3	3	2	2	3	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr20:3102039A>G	uc002whw.2	-	3	1416	c.1246T>C	c.(1246-1248)TGC>CGC	p.C416R	uc002whv.1_Intron|UBOX5_uc002whx.2_Missense_Mutation_p.C416R|UBOX5_uc002why.1_Missense_Mutation_p.C416R	NM_014948	NP_055763	O94941	RNF37_HUMAN	U-box domain containing 5 isoform a	416						nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						CCTGTCGAGCAGTCCATATGT	0.532													49	78					0	0	0	0	G	3102039	G	G	3102039	3	3	23	1	0	0	0	0	1	0	0	0	16962	188	7	5	391	5	UBOX5	20	3102039	Missense_Mutation	SNP	A	TCGA-BB-4223-01A-01D-1434-08	281489	3102039	59923481	326	4941											
CRNKL1	51340	broad.mit.edu	37	chr20	20023027	20023027	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagataaatgtagcgcttcCagtgcctcttctcctgaatg	11	12	8	10	1	2	2	0	1	2	1	4	2	3	2	3	0	2	2	3	0	5	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr20:20023027C>T	uc002wrs.2	-	9	1621	c.1589G>A	c.(1588-1590)TGG>TAG	p.W530*		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	530	HAT 9.				spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						GTAGCGCTTCCAGTGCCTCTT	0.448													6	225					0	0	0	0	T	20023027	T	T	20023027	4	4	23	1	0	0	0	0	0	1	0	0	3906	595	21	4	985	4	CRNKL1	20	20023027	Nonsense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	16920988	20023027	43002493	327	4942											
CRNKL1	51340	broad.mit.edu	37	chr20	20026038	20026038	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagaattccacagctctctCatacactttccgtgcatggg	11	11	7	12	1	2	1	1	0	1	1	5	1	4	1	2	1	3	2	2	1	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr20:20026038C>T	uc002wrs.2	-	7	1230	c.1198G>A	c.(1198-1200)GAG>AAG	p.E400K		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	400	HAT 6.				spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						ACAGCTCTCTCATACACTTTC	0.418													8	289					0	0	0	0	T	20026038	T	T	20026038	3	4	23	1	0	0	0	0	1	0	0	0	3906	835	29	2	1384	2	CRNKL1	20	20026038	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	3011	20026038	42999482	328	4943											
MYL9	10398	broad.mit.edu	37	chr20	35173423	35173423	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatgattgaccagaaccgtGatggcttcattgacaaggag	13	9	11	8	1	1	5	1	4	0	1	1	6	1	6	2	2	1	1	2	2	2	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr20:35173423G>C	uc002xfl.1	+	2	230	c.136G>C	c.(136-138)GAT>CAT	p.D46H	uc002xfk.3_Intron|MYL9_uc002xfm.1_Missense_Mutation_p.D46H	NM_006097	NP_006088	P24844	MYL9_HUMAN	myosin regulatory light chain 9 isoform a	46	|EF-hand 1.				axon guidance|muscle contraction|regulation of muscle contraction	cytosol|muscle myosin complex	calcium ion binding|structural constituent of muscle				0	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCAGAACCGTGATGGCTTCAT	0.572													5	158					0	0	0	0	C	35173423	C	C	35173423	3	2	23	1	0	0	0	0	1	0	0	0	10107	1290	45	2	138	2	MYL9	20	35173423	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	15147385	35173423	27852097	329	4944											
ZMYND8	23613	broad.mit.edu	37	chr20	45905248	45905248	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcagcacaggcttgctcatCaggatcttgggggatgccgt	7	10	13	11	1	4	0	3	0	1	0	4	2	4	2	1	4	3	3	1	4	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr20:45905248C>T	uc002xta.1	-	11	1484	c.1230G>A	c.(1228-1230)CTG>CTA	p.L410L	ZMYND8_uc010ghq.1_Silent_p.L87L|ZMYND8_uc010ghr.1_Silent_p.L385L|ZMYND8_uc002xst.1_Silent_p.L385L|ZMYND8_uc002xsu.1_Silent_p.L410L|ZMYND8_uc002xsv.1_Silent_p.L385L|ZMYND8_uc002xsw.1_Silent_p.L162L|ZMYND8_uc002xsx.1_Silent_p.L162L|ZMYND8_uc002xsy.1_Silent_p.L385L|ZMYND8_uc002xsz.1_Silent_p.L347L|ZMYND8_uc010zxy.1_Silent_p.L437L|ZMYND8_uc002xtb.1_Silent_p.L430L|ZMYND8_uc002xss.2_Silent_p.L410L|ZMYND8_uc010zxz.1_Silent_p.L405L|ZMYND8_uc002xtc.1_Silent_p.L430L|ZMYND8_uc002xtd.1_Silent_p.L405L|ZMYND8_uc002xte.1_Silent_p.L410L|ZMYND8_uc010zya.1_Silent_p.L410L|ZMYND8_uc002xtf.1_Silent_p.L430L|ZMYND8_uc002xtg.2_Silent_p.L404L|ZMYND8_uc010ghs.1_Silent_p.L404L	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	410							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GCTTGCTCATCAGGATCTTGG	0.592													12	185					0	0	0	0	T	45905248	T	T	45905248	2	4	23	1	0	0	0	0	0	0	0	1	17778	813	29	2		2	ZMYND8	20	45905248	Silent	SNP	C	TCGA-BB-4223-01A-01D-1434-08	10731825	45905248	17120272	330	4945											
CTCFL	140690	broad.mit.edu	37	chr20	56099082	56099082	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agctccacttcttcctccagGacgctgtcctggaaggcccc	6	9	9	17	1	1	0	0	0	1	0	5	2	5	2	6	3	1	2	6	3	1	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr20:56099082G>A	uc010gix.1	-	1	842	c.180C>T	c.(178-180)GTC>GTT	p.V60V	CTCFL_uc010giw.1_Silent_p.V60V|CTCFL_uc002xym.2_Silent_p.V60V|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Silent_p.V60V|CTCFL_uc010gjb.1_Silent_p.V60V|CTCFL_uc010gjc.1_Silent_p.V60V|CTCFL_uc010gjd.1_Silent_p.V60V|CTCFL_uc010gje.2_Silent_p.V60V|CTCFL_uc010gjf.2_Intron|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Silent_p.V60V|CTCFL_uc010gji.1_Intron|CTCFL_uc010gjj.1_Silent_p.V60V|CTCFL_uc010gjk.1_Silent_p.V60V|CTCFL_uc010gjl.1_Silent_p.V60V	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	60					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CTTCCTCCAGGACGCTGTCCT	0.587													134	284					0	0	0	0	A	56099082	A	A	56099082	2	1	23	1	0	0	0	0	0	0	0	1	4018	1161	41	2		2	CTCFL	20	56099082	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	10193834	56099082	6926438	331	4946											
IFNAR2	3455	broad.mit.edu	37	chr21	34635244	34635244	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatagcgatactgaggcagcGcccaggacaagtggcggtgg	10	5	17	9	3	0	1	0	1	0	0	0	4	0	2	1	5	3	1	1	5	3	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr21:34635244G>T	uc002yrd.2	+	9	1315	c.987G>T	c.(985-987)GCG>GCT	p.A329A	IFNAR2_uc002yre.2_Silent_p.A329A|IFNAR2_uc002yrf.2_3'UTR|IL10RB_uc002yrh.1_Intron|IL10RB_uc002yri.1_Intron	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	329	Cytoplasmic (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	CTGAGGCAGCGCCCAGGACAA	0.498													7	183					5.18039e-06	5.3358e-06	1	0	T	34635244	T	T	34635244	2	4	23	1	0	0	0	0	0	0	0	1	7584	1074	38	3		3	IFNAR2	21	34635244	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08		34635244	13494651	332	4947											
TFIP11	24144	broad.mit.edu	37	chr22	26894918	26894918	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcttttccacttagagatGatctcggtgccataagtgca	10	12	10	9	1	1	2	0	1	1	1	3	3	2	2	2	2	2	2	2	2	2	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr22:26894918G>A	uc003acr.2	-	9	1727	c.1353C>T	c.(1351-1353)ATC>ATT	p.I451I	TFIP11_uc003acs.2_Silent_p.I451I|TFIP11_uc003act.2_Silent_p.I451I	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	451					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						ACTTAGAGATGATCTCGGTGC	0.552													19	333					0	0	0	0	A	26894918	A	A	26894918	2	1	23	1	0	0	0	0	0	0	0	1	15873	1280	45	2		2	TFIP11	22	26894918	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08		26894918	24409648	333	4948											
TFIP11	24144	broad.mit.edu	37	chr22	26895394	26895394	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgccggtcattctggatGatctcctgctccgtgaggtc	5	12	12	12	2	3	2	1	2	2	0	6	3	4	3	3	3	3	2	3	3	0	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr22:26895394G>A	uc003acr.2	-	8	1379	c.1005C>T	c.(1003-1005)ATC>ATT	p.I335I	TFIP11_uc003acs.2_Silent_p.I335I|TFIP11_uc003act.2_Silent_p.I335I	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	335					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						CATTCTGGATGATCTCCTGCT	0.622													5	216					0	0	0	0	A	26895394	A	A	26895394	2	1	23	1	0	0	0	0	0	0	0	1	15873	1280	45	2		2	TFIP11	22	26895394	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	476	26895394	24409172	334	4949											
BPIL2	254240	broad.mit.edu	37	chr22	32828417	32828417	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgggttgggtgagcatcatGatggaggcagggatgtccag	8	10	18	5	0	1	2	1	2	0	0	2	4	2	4	1	5	1	3	1	5	0	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr22:32828417G>C	uc003amn.2	-	10	1092	c.1092C>G	c.(1090-1092)ATC>ATG	p.I364M	BPIL2_uc010gwo.2_Intron|BPIL2_uc011amb.1_Missense_Mutation_p.I88M	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	364						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						TGAGCATCATGATGGAGGCAG	0.517													6	161					0	0	0	0	C	32828417	C	C	32828417	3	2	23	1	0	0	0	0	1	0	0	0	1497	1280	45	2	455	2	BPIL2	22	32828417	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	5933023	32828417	18476149	335	4950											
CDC42EP1	11135	broad.mit.edu	37	chr22	37962692	37962692	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccccggctccaccggccatCtcccccatcatcaagaacgc	8	6	6	21	3	3	1	2	0	1	1	6	1	5	1	7	2	1	1	7	2	2	0			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr22:37962692C>G	uc003asz.3	+	2	739	c.336C>G	c.(334-336)ATC>ATG	p.I112M		NM_152243	NP_689449	Q00587	BORG5_HUMAN	CDC42 effector protein 1	112					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding				0	Melanoma(58;0.0574)					CACCGGCCATCTCCCCCATCA	0.682													5	189					0	0	0	0	G	37962692	G	G	37962692	3	3	23	1	0	0	0	0	1	0	0	0	3090	903	32	2	338	2	CDC42EP1	22	37962692	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08	5134275	37962692	13341874	336	4951											
LGALS1	3956	broad.mit.edu	37	chr22	38073070	38073070	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggtggctcctgacgctaaGaggtgagaagtgaagtcggg	10	7	18	6	2	0	4	0	3	0	2	2	6	1	4	1	4	0	2	1	4	3	1			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr22:38073070G>C	uc003atn.2	+	2	184	c.87G>C	c.(85-87)AAG>AAC	p.K29N		NM_002305	NP_002296	P09382	LEG1_HUMAN	galectin-1	29	Galectin.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of apoptosis	cytoplasm|extracellular space|proteinaceous extracellular matrix	galactoside binding|signal transducer activity				0	Melanoma(58;0.0574)					CTGACGCTAAGAGGTGAGAAG	0.667													4	63					0	0	0	0	C	38073070	C	C	38073070	3	2	23	1	0	0	0	0	1	0	0	0	8778	933	33	2	93	2	LGALS1	22	38073070	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	110378	38073070	13231496	337	4952											
EIF3L	51386	broad.mit.edu	37	chr22	38254699	38254699	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttcagatgctgtcttcctGattttatacaaagaattata	12	17	5	7	0	2	3	1	1	1	2	3	3	3	3	1	0	2	1	1	0	6	7			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr22:38254699G>C	uc003auf.2	+	5	474	c.387G>C	c.(385-387)CTG>CTC	p.L129L	EIF3L_uc003aue.1_Silent_p.L129L|EIF3L_uc011ann.1_Silent_p.L129L|EIF3L_uc003aug.2_Silent_p.L21L	NM_016091	NP_057175	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3	129						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1						CTGTCTTCCTGATTTTATACA	0.378													16	556					0	0	0	0	C	38254699	C	C	38254699	2	2	23	1	0	0	0	0	0	0	0	1	5046	1277	45	2		2	EIF3L	22	38254699	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	181629	38254699	13049867	338	4953											
TAB1	10454	broad.mit.edu	37	chr22	39814772	39814772	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttttatgcaaatcgacagtgGatgggttgcaggtgacacag	11	11	13	6	1	0	1	0	1	0	0	1	3	0	2	0	3	2	3	0	3	2	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr22:39814772G>C	uc003axt.2	+	6	635	c.586G>C	c.(586-588)GAT>CAT	p.D196H	TAB1_uc003axr.2_Missense_Mutation_p.D272H|TAB1_uc011aok.1_Missense_Mutation_p.D30H|TAB1_uc003axu.1_Missense_Mutation_p.D196H	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	196	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						ATCGACAGTGGATGGGTTGCA	0.527													40	94					0	0	0	0	C	39814772	C	C	39814772	3	2	23	1	0	0	0	0	1	0	0	0	15561	1174	41	2	608	2	TAB1	22	39814772	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	1560073	39814772	11489794	339	4954											
MAPK12	6300	broad.mit.edu	37	chr22	50695547	50695547	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atctggtacacgaggaactgGatccggtcctcgcctagctt	8	10	11	12	3	1	0	0	0	1	0	4	3	3	2	3	4	3	2	3	4	3	3			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr22:50695547G>C	uc003bkm.1	-	4	541	c.390C>G	c.(388-390)ATC>ATG	p.I130M	MAPK12_uc003bkn.2_Translation_Start_Site|MAPK12_uc003bko.2_Missense_Mutation_p.I50M|MAPK12_uc003bkl.1_Missense_Mutation_p.I130M|MAPK12_uc003bkp.2_5'Flank|MAPK12_uc003bkq.2_Intron	NM_002969	NP_002960	P53778	MK12_HUMAN	mitogen-activated protein kinase 12	130	Protein kinase.				cell cycle arrest|DNA damage induced protein phosphorylation|muscle organ development|myoblast differentiation|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction	mitochondrion|nucleoplasm	ATP binding|magnesium ion binding|MAP kinase activity|protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGAGGAACTGGATCCGGTCCT	0.667													7	98					0	0	0	0	C	50695547	C	C	50695547	3	2	23	1	0	0	0	0	1	0	0	0	9327	1164	41	2	749	2	MAPK12	22	50695547	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	10880775	50695547	609019	340	4955											
SBF1	6305	broad.mit.edu	37	chr22	50898407	50898407	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagatggcatacatgcggttGaccggagaaatgcggaaggg	12	6	16	7	3	0	3	0	1	0	2	0	5	0	4	1	5	3	2	1	5	3	2			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chr22:50898407G>C	uc003blh.2	-	26	3660	c.3465C>G	c.(3463-3465)GTC>GTG	p.V1155V	SBF1_uc011arx.1_Silent_p.V819V	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1155	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		ACATGCGGTTGACCGGAGAAA	0.677													5	155					0	0	0	0	C	50898407	C	C	50898407	2	2	23	1	0	0	0	0	0	0	0	1	13923	1277	45	2		2	SBF1	22	50898407	Silent	SNP	G	TCGA-BB-4223-01A-01D-1434-08	202860	50898407	406159	341	4956											
ARSH	347527	broad.mit.edu	37	chrX	2947379	2947379	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccactactgtggggtctatCtgcacacggtcaggtggcat	7	11	12	11	1	3	0	1	0	2	0	4	0	4	0	1	5	2	2	1	5	2	2	rs145847839	byFrequency	TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chrX:2947379C>G	uc011mhj.1	+	8	1291	c.1291C>G	c.(1291-1293)CTG>GTG	p.L431V		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	431						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TGGGGTCTATCTGCACACGGT	0.572													9	97					0	0	0	0	G	2947379	G	G	2947379	3	3	23	1	0	0	0	0	1	0	0	0	995	912	32	2	1321	2	ARSH	23	2947379	Missense_Mutation	SNP	C	TCGA-BB-4223-01A-01D-1434-08		2947379	152323181	342	4957											
S100G	795	broad.mit.edu	37	chrX	16669151	16669151	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagtactaaaaagtctcctGaggaactgaagaggattttt	14	12	10	5	0	1	4	0	3	1	1	2	6	1	6	1	2	2	1	1	2	6	4			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chrX:16669151G>A	uc004cxn.1	+	2	76	c.22G>A	c.(22-24)GAG>AAG	p.E8K	CTPS2_uc004cxk.2_Intron|CTPS2_uc004cxl.2_Intron|CTPS2_uc004cxm.2_Intron	NM_004057	NP_004048	P29377	S100G_HUMAN	calbindin 3	8							calcium ion binding|vitamin D binding				0	Hepatocellular(33;0.0997)					AAAGTCTCCTGAGGAACTGAA	0.393													5	103					0	0	0	0	A	16669151	A	A	16669151	3	1	23	1	0	0	0	0	1	0	0	0	13854	1291	45	2	24	2	S100G	23	16669151	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	13721772	16669151	138601409	343	4958											
CPXCR1	53336	broad.mit.edu	37	chrX	88008677	88008677	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaagaagatctaaaagaaGagcttcttctacttcagacc	16	9	8	8	0	4	6	1	0	3	6	4	7	4	6	1	0	2	1	1	0	6	5			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chrX:88008677G>C	uc004efd.3	+	3	521	c.262G>C	c.(262-264)GAG>CAG	p.E88Q	CPXCR1_uc004efc.3_Missense_Mutation_p.E88Q	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	88						intracellular	zinc ion binding			ovary(3)	3						TCTAAAAGAAGAGCTTCTTCT	0.443													26	9					0	0	0	0	C	88008677	C	C	88008677	3	2	23	1	0	0	0	0	1	0	0	0	3851	943	33	2	264	2	CPXCR1	23	88008677	Missense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	71339526	88008677	67261883	344	4959											
MCF2	4168	broad.mit.edu	37	chrX	138698572	138698572	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagcatcttctttagactGaaacttatctatttcctgat	10	17	5	9	0	3	4	0	3	3	1	4	4	4	4	1	0	2	1	1	0	4	6			TCGA-BB-4223-01A-01D-1434-08	TCGA-BB-4223-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	c4799ee4-3014-4b2f-ba7e-9771ab5dc3f1	5e0586d3-8efa-4b1c-a91c-993472fae18f	g.chrX:138698572G>A	uc004fau.2	-	9	1354	c.1060C>T	c.(1060-1062)CAG>TAG	p.Q354*	MCF2_uc004fav.2_Nonsense_Mutation_p.Q354*|MCF2_uc011mwl.1_Nonsense_Mutation_p.Q315*|MCF2_uc010nsh.1_Nonsense_Mutation_p.Q354*|MCF2_uc011mwm.1_Nonsense_Mutation_p.Q315*|MCF2_uc011mwn.1_Nonsense_Mutation_p.Q499*|MCF2_uc004faw.2_Nonsense_Mutation_p.Q414*|MCF2_uc011mwo.1_Nonsense_Mutation_p.Q414*	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	354					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TCTTTAGACTGAAACTTATCT	0.338													4	67					0	0	0	0	A	138698572	A	A	138698572	4	1	23	1	0	0	0	0	0	1	0	0	9431	1299	45	2	1865	2	MCF2	23	138698572	Nonsense_Mutation	SNP	G	TCGA-BB-4223-01A-01D-1434-08	50689895	138698572	16571988	345	4960											
GPATCH3	63906	broad.mit.edu	37	chr1	27226589	27226589	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtacatgcgaataagcctCtgagcttgagccaaccccct	11	8	9	13	1	1	2	0	2	1	0	1	4	1	2	4	0	6	2	4	0	4	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr1:27226589C>G	uc001bne.2	-	1	374	c.345G>C	c.(343-345)CAG>CAC	p.Q115H	GPATCH3_uc009vsp.1_Intron	NM_022078	NP_071361	Q96I76	GPTC3_HUMAN	G patch domain containing 3	115						intracellular	nucleic acid binding				0		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		GAATAAGCCTCTGAGCTTGAG	0.622													42	84					0	0	0	0	G	27226589	G	G	27226589	3	3	24	1	0	0	0	0	1	0	0	0	6630	912	32	2	1260	2	GPATCH3	1	27226589	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08		27226589	222024032	1	4961											
OSCP1	127700	broad.mit.edu	37	chr1	36904426	36904426	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgctcatagacagtcctcagGgccttcttggagtagagctc	8	10	11	12	1	3	2	2	0	1	2	5	3	4	3	2	2	1	3	2	2	2	4	rs139567315	byFrequency	TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr1:36904426G>A	uc001cap.2	-	3	310	c.228C>T	c.(226-228)GCC>GCT	p.A76A	OSCP1_uc001caq.2_Silent_p.A66A|OSCP1_uc001car.2_Silent_p.A66A	NM_145047	NP_659484	Q8WVF1	OSCP1_HUMAN	oxidored-nitro domain-containing protein isoform	76					transport	basal plasma membrane				ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAGTCCTCAGGGCCTTCTTGG	0.473													28	63					0	0	0	0	A	36904426	A	A	36904426	2	1	24	1	0	0	0	0	0	0	0	1	11340	1219	43	4		4	OSCP1	1	36904426	Silent	SNP	G	TCGA-BB-4224-01A-01D-1434-08	9677837	36904426	212346195	2	4962											
TMEM48	55706	broad.mit.edu	37	chr1	54275387	54275387	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcatctatgtgaaggttcaTagcagtgctaatccaagctt	11	13	8	9	0	3	1	2	1	1	0	4	1	4	1	1	1	3	4	1	1	5	5	rs140272518		TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr1:54275387T>C	uc001cvs.2	-	7	977	c.736A>G	c.(736-738)ATG>GTG	p.M246V	TMEM48_uc010onu.1_Missense_Mutation_p.M206V|TMEM48_uc001cvt.2_Missense_Mutation_p.M123V|TMEM48_uc009vzk.2_RNA|TMEM48_uc010onv.1_5'UTR	NM_018087	NP_060557	Q9BTX1	NDC1_HUMAN	transmembrane protein 48	246	Helical; Name=5; (Potential).				mRNA transport|nuclear pore complex assembly|nuclear pore distribution|protein transport|transmembrane transport	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore			ovary(1)|pancreas(1)	2						TGAAGGTTCATAGCAGTGCTA	0.308													45	44					0	0	0	0	C	54275387	C	C	54275387	3	2	24	1	0	0	0	0	1	0	0	0	16238	1406	49	5	1336	5	TMEM48	1	54275387	Missense_Mutation	SNP	T	TCGA-BB-4224-01A-01D-1434-08	17370961	54275387	194975234	3	4963											
FAM151A	338094	broad.mit.edu	37	chr1	55078320	55078320	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggggacgtggacatgtaGaaggtggtccagcctggaga	9	9	17	6	1	0	2	0	0	0	2	1	5	1	4	2	6	1	1	2	6	2	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr1:55078320G>T	uc001cxn.2	-	5	771	c.639C>A	c.(637-639)TTC>TTA	p.F213L	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	213						integral to membrane					0						TGGACATGTAGAAGGTGGTCC	0.567													16	76					6.94344e-10	7.41023e-10	1	0	T	55078320	T	T	55078320	3	4	24	1	0	0	0	0	1	0	0	0	5486	933	33	2	1134	2	FAM151A	1	55078320	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	802933	55078320	194172301	4	4964											
RPRD2	23248	broad.mit.edu	37	chr1	150390094	150390095	+	Missense_Mutation	DNP	TC	AG	AG																															gcatatccccaccgtttgaaTctcttttaccttgccaatga																										TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr1:150390094_150390095TC>AG	uc009wlr.2	+	2	429_430	c.228_229TC>AG	c.(226-231)AATCTC>AAAGTC	p.76_77NL>KV	RPRD2_uc010pcc.1_Missense_Mutation_p.76_77NL>KV|RPRD2_uc001eup.3_Missense_Mutation_p.76_77NL>KV	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	76_77	CID.						protein binding			ovary(1)	1						ACCGTTTGAATCTCTTTTACCT	0.361													81	207					0	0	0	0	AG	150390095	AG	AG	150390094	3	1	24	1	0	0	0	0	1	0	0	0	13682	1432	50	5	234	5	RPRD2	1	150390094	Missense_Mutation	DNP	TC	TCGA-BB-4224-01A-01D-1434-08	95311774	150390094	98860527	5	4965											
ACBD6	84320	broad.mit.edu	37	chr1	180471245	180471245	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacctgaatcaggccttgcaGgtgcgcggcagccttctcaa	8	8	11	14	2	2	1	2	1	1	0	3	1	2	1	3	3	3	2	3	3	2	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr1:180471245G>T	uc001gog.2	-	1	778	c.157C>A	c.(157-159)CTG>ATG	p.L53M		NM_032360	NP_115736	Q9BR61	ACBD6_HUMAN	acyl-coenzyme A binding domain containing 6	53	ACB.					cytoplasm|nucleus	fatty-acyl-CoA binding			ovary(1)	1						AGGCCTTGCAGGTGCGCGGCA	0.602													32	10					6.50621e-10	7.00245e-10	1	0	T	180471245	T	T	180471245	3	4	24	1	0	0	0	0	1	0	0	0	126	991	35	4	723	4	ACBD6	1	180471245	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	30081151	180471245	68779376	6	4966											
PCNXL2	80003	broad.mit.edu	37	chr1	233275516	233275516	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatcaatagtgagggcattCaaaattagcgctgggtacaa	14	9	11	7	1	2	1	2	1	0	0	2	1	2	1	0	2	2	4	0	2	7	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr1:233275516C>G	uc001hvl.2	-	20	3838	c.3603G>C	c.(3601-3603)TTG>TTC	p.L1201F	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1201	Helical; (Potential).					integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TGAGGGCATTCAAAATTAGCG	0.358													6	21					0	0	0	0	G	233275516	G	G	233275516	3	3	24	1	0	0	0	0	1	0	0	0	11646	825	29	2	2870	2	PCNXL2	1	233275516	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	52804271	233275516	15975105	7	4967											
NRXN1	9378	broad.mit.edu	37	chr2	50464073	50464073	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccacttatacgtgatttGtccaccacctttgctaaaga	11	12	7	11	1	0	2	0	1	0	1	1	2	1	2	4	1	2	1	4	1	4	5			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr2:50464073G>C	uc010fbp.2	-	2	1102	c.295C>G	c.(295-297)CAA>GAA	p.Q99E	NRXN1_uc002rxb.3_Missense_Mutation_p.Q806E|NRXN1_uc010fbq.2_Missense_Mutation_p.Q1174E|NRXN1_uc002rxe.3_Missense_Mutation_p.Q1134E|NRXN1_uc002rxc.1_RNA	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	99	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TACGTGATTTGTCCACCACCT	0.448													40	106					0	0	0	0	C	50464073	C	C	50464073	3	2	24	1	0	0	0	0	1	0	0	0	10719	1386	48	4	1147	4	NRXN1	2	50464073	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08		50464073	192735300	8	4968											
IL1F7	27178	broad.mit.edu	37	chr2	113675313	113675313	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagttttgtctctactgtGacaaggataaaggacaaagt	13	11	12	5	0	1	1	0	1	1	0	2	4	1	4	0	3	1	1	0	3	5	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr2:113675313G>C	uc002tij.2	+	4	409	c.367G>C	c.(367-369)GAC>CAC	p.D123H	IL1F7_uc002tik.2_Missense_Mutation_p.D102H|IL1F7_uc002til.2_Missense_Mutation_p.D83H|IL1F7_uc002tim.2_Missense_Mutation_p.D62H|IL1F7_uc002tin.2_Missense_Mutation_p.D97H	NM_014439	NP_055254	Q9NZH6	IL37_HUMAN	interleukin 1 family, member 7 isoform 1	123					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding				0						TCTCTACTGTGACAAGGATAA	0.488													47	145					0	0	0	0	C	113675313	C	C	113675313	3	2	24	1	0	0	0	0	1	0	0	0	7694	1290	45	2	452	2	IL1F7	2	113675313	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	63211240	113675313	129524060	9	4969											
LRP2	4036	broad.mit.edu	37	chr2	170063539	170063539	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtggtgtgacaatgccctCtgacacaagcactgttcgat	9	10	10	12	2	1	2	0	2	1	0	2	3	1	2	2	1	2	2	2	1	2	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr2:170063539C>T	uc002ues.2	-	39	6904	c.6691G>A	c.(6691-6693)GAG>AAG	p.E2231K		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2231	LDL-receptor class B 22.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACAATGCCCTCTGACACAAGC	0.463													68	185					0	0	0	0	T	170063539	T	T	170063539	3	4	24	1	0	0	0	0	1	0	0	0	9006	922	32	2	7440	2	LRP2	2	170063539	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	56388226	170063539	73135834	10	4970											
CTNNB1	1499	broad.mit.edu	37	chr3	41275254	41275254	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttcgtcatctgaccagcCgacaccaagaagcagagatg	12	7	9	13	2	3	3	1	1	2	2	4	5	3	3	3	0	2	1	3	0	2	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr3:41275254C>T	uc010hia.1	+	10	1576	c.1420C>T	c.(1420-1422)CGA>TGA	p.R474*	CTNNB1_uc003ckp.2_Nonsense_Mutation_p.R474*|CTNNB1_uc003ckq.2_Nonsense_Mutation_p.R474*|CTNNB1_uc003ckr.2_Nonsense_Mutation_p.R474*|CTNNB1_uc011azf.1_Nonsense_Mutation_p.R467*|CTNNB1_uc011azg.1_Nonsense_Mutation_p.R402*|CTNNB1_uc003cks.2_Nonsense_Mutation_p.R77*|CTNNB1_uc003ckt.1_5'Flank	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	474	ARM 8.				adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TCTGACCAGCCGACACCAAGA	0.542		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				75	103					0	0	0	0	T	41275254	T	T	41275254	4	4	24	1	0	0	0	0	0	1	0	0	4033	644	23	1	1450	1	CTNNB1	3	41275254	Nonsense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08		41275254	156747176	11	4971											
COL6A6	131873	broad.mit.edu	37	chr3	130300633	130300633	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtttgagatctacagtgAaaacatactgaatagcttga	16	11	8	6	0	1	4	0	4	1	1	1	5	1	4	0	0	4	2	0	0	7	5			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr3:130300633A>G	uc010htl.2	+	8	3807	c.3776A>G	c.(3775-3777)GAA>GGA	p.E1259G	COL6A6_uc003eni.3_5'Flank	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1259	VWFA 7.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						ATCTACAGTGAAAACATACTG	0.403													54	207					0	0	0	0	G	130300633	G	G	130300633	3	3	24	1	0	0	0	0	1	0	0	0	3718	246	9	5	3806	5	COL6A6	3	130300633	Missense_Mutation	SNP	A	TCGA-BB-4224-01A-01D-1434-08	89025379	130300633	67721797	12	4972											
MRFAP1L1	114932	broad.mit.edu	37	chr4	6711285	6711285	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accgggagcaggaactgctcGaaatcctcctcgggctccag	9	6	12	14	3	0	0	0	0	0	0	5	3	3	2	4	3	3	3	4	3	2	0			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr4:6711285G>A	uc003gjn.2	-	1	312	c.72C>T	c.(70-72)TTC>TTT	p.F24F	MRFAP1L1_uc003gjo.2_Silent_p.F24F	NM_203462	NP_982287	Q96HT8	MR1L1_HUMAN	Morf4 family associated protein 1-like 1	24											0						GGAACTGCTCGAAATCCTCCT	0.632													29	51					0	0	0	0	A	6711285	A	A	6711285	2	1	24	1	0	0	0	0	0	0	0	1	9815	1049	37	1		1	MRFAP1L1	4	6711285	Silent	SNP	G	TCGA-BB-4224-01A-01D-1434-08		6711285	184442991	13	4973											
CEP135	9662	broad.mit.edu	37	chr4	56830566	56830566	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttattgctcatttaaatattCaggtaatggcttttataatt	12	20	5	4	0	2	0	2	0	0	0	2	0	2	0	0	2	1	3	0	2	7	11			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr4:56830566C>G	uc003hbi.2	+	7	1060	c.826C>G	c.(826-828)CAG>GAG	p.Q276E	CEP135_uc003hbj.2_5'Flank|CEP135_uc010igz.1_Missense_Mutation_p.Q106E	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	276	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					TTTAAATATTCAGGTAATGGC	0.348													14	32					0	0	0	0	G	56830566	G	G	56830566	3	3	24	1	0	0	0	0	1	0	0	0	3262	827	29	2	848	2	CEP135	4	56830566	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	50119281	56830566	134323710	14	4974											
YTHDC1	91746	broad.mit.edu	37	chr4	69195943	69195944	+	Frame_Shift_Del	DEL	AC	-	-																															gaaattttccactctctctgAcagaaaatattaagataaca																										TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr4:69195943_69195944delAC	uc003hdx.2	-	8	1560_1561	c.1207_1208delGT	c.(1207-1209)GTCfs	p.V403fs	YTHDC1_uc003hdy.2_Frame_Shift_Del_p.V385fs	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	403	YTH.									upper_aerodigestive_tract(1)|ovary(1)	2						ACTCTCTCTGACAGAAAATATT	0.277													---	---	---								-	69195944	-	-	69195943	7	5	24	1	0	1	0	1	0	0	0	0	17564	275	10	0	1015	0	YTHDC1	4	69195943	Frame_Shift_Del	DEL	AC	TCGA-BB-4224-01A-01D-1434-08	12365377	69195943	121958333	15	4975											
PLA2G12A	81579	broad.mit.edu	37	chr4	110650952	110650952	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggagggtgagcgcggggcgcGagagcagggccatgcgcgca	7	2	22	10	6	0	2	0	1	0	1	0	4	0	3	1	5	3	2	1	5	0	0			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr4:110650952G>C	uc003hzp.2	-	1	291	c.14C>G	c.(13-15)TCG>TGG	p.S5W	PLA2G12A_uc010img.2_Missense_Mutation_p.S5W	NM_030821	NP_110448	Q9BZM1	PG12A_HUMAN	phospholipase A2, group XIIA precursor	5					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity				0				OV - Ovarian serous cystadenocarcinoma(123;0.000268)		CGCGGGGCGCGAGAGCAGGGC	0.736													2	5					0	0	0	0	C	110650952	C	C	110650952	3	2	24	1	0	0	0	0	1	0	0	0	12045	1059	37	3	571	3	PLA2G12A	4	110650952	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	41455009	110650952	80503324	16	4976											
PRSS12	8492	broad.mit.edu	37	chr4	119273941	119273941	+	5'Flank	DEL	G	-	-																															gcttggagcggagaagaggaGggggcgggggcggggctgcc																										TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr4:119273941delG	uc003ica.1	-							NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor							membrane	scavenger receptor activity			skin(1)	1						GAGAAGAGGAGGGGGCGGGGG	0.736													---	---	---								-	119273941	-	-	119273941	6	5	24	0	1	1	0	1	0	0	0	0	12677	1015	35	0		0	PRSS12	4	119273941	5'Flank	DEL	G	TCGA-BB-4224-01A-01D-1434-08	8622989	119273941	71880335	17	4977											
C4orf31	79625	broad.mit.edu	37	chr4	121958285	121958285	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcaaccttgggcctggagtAgacatgacgccccagttttg	9	10	11	11	1	1	2	1	1	0	1	1	3	1	3	4	2	1	2	4	2	2	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr4:121958285A>C	uc003idq.1	-	4	1368	c.841T>G	c.(841-843)TAC>GAC	p.Y281D		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	281	Fibronectin type-III 1.										0						GGCCTGGAGTAGACATGACGC	0.458													20	85					0	0	0	0	C	121958285	C	C	121958285	3	2	24	1	0	0	0	0	1	0	0	0	2271	420	15	5	869	5	C4orf31	4	121958285	Missense_Mutation	SNP	A	TCGA-BB-4224-01A-01D-1434-08	2684344	121958285	69195991	18	4978											
TDO2	6999	broad.mit.edu	37	chr4	156825277	156825277	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctatgggaactacctgcatgTaagtggcagggtccttacag	10	10	12	9	0	0	0	0	0	0	0	1	1	1	1	2	3	4	3	2	3	5	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr4:156825277T>C	uc003ipf.1	+	2	205	c.141_splice	c.e2+2	p.H47_splice		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase						tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	TACCTGCATGTAAGTGGCAGG	0.423													24	33					0	0	0	0	C	156825277	C	C	156825277	5	2	24	1	0	0	0	0	0	0	1	0	15793	1652	57	5	149	5	TDO2	4	156825277	Splice_Site	SNP	T	TCGA-BB-4224-01A-01D-1434-08	34866992	156825277	34328999	19	4979											
DNAH5	1767	broad.mit.edu	37	chr5	13817674	13817674	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacctttctttgctcttaatGttttcctccaaagcgtagaa	9	17	5	10	1	2	1	0	0	2	1	4	1	4	1	3	0	3	3	3	0	5	7			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr5:13817674G>T	uc003jfd.2	-	42	7013	c.6971C>A	c.(6970-6972)ACA>AAA	p.T2324K		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2324	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGCTCTTAATGTTTTCCTCCA	0.383									Kartagener_syndrome				20	123					5.35267e-07	5.66491e-07	1	0	T	13817674	T	T	13817674	3	4	24	1	0	0	0	0	1	0	0	0	4626	1377	48	4	7055	4	DNAH5	5	13817674	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08		13817674	167097586	20	4980											
MYO10	4651	broad.mit.edu	37	chr5	16694532	16694532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttctcctcgctgtcgttttCaaagtacatcagcttggact	7	15	7	12	2	3	0	2	0	1	0	6	1	3	1	1	1	2	4	1	1	2	5			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr5:16694532C>T	uc003jft.3	-	27	4216	c.3748G>A	c.(3748-3750)GAA>AAA	p.E1250K	MYO10_uc011cnc.1_Missense_Mutation_p.E129K|MYO10_uc011cnd.1_Missense_Mutation_p.E607K|MYO10_uc011cne.1_Missense_Mutation_p.E607K|MYO10_uc010itx.2_Missense_Mutation_p.E873K	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1250	PH 1.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CTGTCGTTTTCAAAGTACATC	0.552													61	227					0	0	0	0	T	16694532	T	T	16694532	3	4	24	1	0	0	0	0	1	0	0	0	10115	835	29	2	2488	2	MYO10	5	16694532	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	2876858	16694532	164220728	21	4981											
FYB	2533	broad.mit.edu	37	chr5	39139348	39139348	+	Frame_Shift_Del	DEL	C	-	-																															atctgacctcatctagatttCcagcacctaaaagattaaaa																										TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr5:39139348delC	uc003jls.2	-	4	1413	c.1346delG	c.(1345-1347)GGAfs	p.G449fs	FYB_uc003jlt.2_Frame_Shift_Del_p.G449fs|FYB_uc003jlu.2_Frame_Shift_Del_p.G449fs|FYB_uc011cpl.1_Frame_Shift_Del_p.G459fs	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	449					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			ATCTAGATTTCCAGCACCTAA	0.244													---	---	---								-	39139348	-	-	39139348	7	5	24	1	0	1	0	1	0	0	0	0	6158	855	30	0	1203	0	FYB	5	39139348	Frame_Shift_Del	DEL	C	TCGA-BB-4224-01A-01D-1434-08	22444816	39139348	141775912	22	4982											
RREB1	6239	broad.mit.edu	37	chr6	7229363	7229363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccatgtggcggcagaccaggGtcaagaaaagccgcaggcca	12	3	14	12	2	1	2	1	0	0	2	1	2	1	2	4	4	1	2	4	4	3	0	rs114551633	by1000genomes	TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr6:7229363G>A	uc003mxc.2	+	10	1421	c.1031G>A	c.(1030-1032)GGT>GAT	p.G344D	RREB1_uc003mxb.2_Missense_Mutation_p.G344D|RREB1_uc010jnx.2_Missense_Mutation_p.G344D	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	344					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GCAGACCAGGGTCAAGAAAAG	0.622													16	30					0	0	0	0	A	7229363	A	A	7229363	3	1	24	1	0	0	0	0	1	0	0	0	13744	1261	44	4	1057	4	RREB1	6	7229363	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08		7229363	163885704	23	4983											
HIST1H2BK	85236	broad.mit.edu	37	chr6	27114408	27114408	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatgattcccatggccttaGaggagatgccggtgtcgggg	7	10	15	9	2	1	3	1	1	0	2	3	4	2	3	3	5	1	0	3	5	1	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr6:27114408G>C	uc003nix.1	-	1	212	c.170C>G	c.(169-171)TCT>TGT	p.S57C	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	57					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						CATGGCCTTAGAGGAGATGCC	0.577													69	414					0	0	0	0	C	27114408	C	C	27114408	3	2	24	1	0	0	0	0	1	0	0	0	7189	942	33	2	214	2	HIST1H2BK	6	27114408	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	19885045	27114408	144000659	24	4984											
OR5V1	81696	broad.mit.edu	37	chr6	29323454	29323454	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacagaagaagtaattaatCtgattgttgccacagaaggg	15	10	10	6	0	2	4	1	1	1	3	2	4	2	4	1	1	1	2	1	1	5	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr6:29323454C>A	uc011dlo.1	-	1	601	c.519G>T	c.(517-519)CAG>CAT	p.Q173H		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						AGTAATTAATCTGATTGTTGC	0.463													35	140					3.93418e-24	4.50127e-24	1	0	A	29323454	A	A	29323454	3	1	24	1	0	0	0	0	1	0	0	0	11238	912	32	2	449	2	OR5V1	6	29323454	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	2209046	29323454	141791613	25	4985											
TNFRSF21	27242	broad.mit.edu	37	chr6	47254185	47254185	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagacgcgcaggcttgtgttGgtacaatgctcagagacata	11	9	12	9	2	1	2	1	0	0	2	1	3	1	2	0	2	2	5	0	2	3	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr6:47254185G>T	uc003oyv.2	-	2	676	c.243C>A	c.(241-243)ACC>ACA	p.T81T		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	81	Extracellular (Potential).|TNFR-Cys 1.				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			GGCTTGTGTTGGTACAATGCT	0.542													20	57					3.51602e-12	3.81653e-12	1	0	T	47254185	T	T	47254185	2	4	24	1	0	0	0	0	0	0	0	1	16361	1335	47	4		4	TNFRSF21	6	47254185	Silent	SNP	G	TCGA-BB-4224-01A-01D-1434-08	17930731	47254185	123860882	26	4986											
AKAP12	9590	broad.mit.edu	37	chr6	151671735	151671735	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggttcccaagaacatgatCcagggcagggaagttcctcc	10	8	11	12	0	0	2	0	1	0	1	4	3	4	3	4	3	1	3	4	3	3	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr6:151671735C>A	uc011eep.1	+	4	2449	c.2209C>A	c.(2209-2211)CCA>ACA	p.P737T	AKAP12_uc003qoe.2_Missense_Mutation_p.P737T|AKAP12_uc003qof.2_Missense_Mutation_p.P639T|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.P632T	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	737					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		AGAACATGATCCAGGGCAGGG	0.547													67	181					8.33888e-18	9.2898e-18	1	0	A	151671735	A	A	151671735	3	1	24	1	0	0	0	0	1	0	0	0	448	855	30	2	2248	2	AKAP12	6	151671735	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	104417550	151671735	19443332	27	4987											
TNRC18	84629	broad.mit.edu	37	chr7	5413746	5413746	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caactccaagtctttcttctCgaccacattctcgggagcct	8	12	6	15	2	4	0	0	0	4	0	7	2	5	1	3	1	2	0	3	1	2	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr7:5413746C>T	uc003soi.3	-	10	3518	c.3169G>A	c.(3169-3171)GAG>AAG	p.E1057K		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1057	Pro-rich.						DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		TCTTTCTTCTCGACCACATTC	0.677													3	40					0	0	0	0	T	5413746	T	T	5413746	3	4	24	1	0	0	0	0	1	0	0	0	16405	893	31	1	5821	1	TNRC18	7	5413746	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08		5413746	153724917	28	4988											
MGC87042	256227	broad.mit.edu	37	chr7	22534408	22534408	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccaaataatcgttgtcttCtaaatttctcctaggcttca	11	16	4	10	1	4	0	1	0	3	0	6	0	4	0	2	1	1	2	2	1	6	8			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr7:22534408C>A	uc003svh.2	-	2	164	c.67G>T	c.(67-69)GAA>TAA	p.E23*	MGC87042_uc010kum.1_Nonsense_Mutation_p.E23*			Q6NZ63	STEAL_HUMAN	SubName: Full=cDNA FLJ60218, highly similar to Six transmembrane epithelial antigen ofprostate 1;	23						integral to membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0						TCGTTGTCTTCTAAATTTCTC	0.274													9	71					0.000274275	0.000280911	1	0	A	22534408	A	A	22534408	4	1	24	1	0	0	0	0	0	1	0	0	9607	922	32	2	1014	2	MGC87042	7	22534408	Nonsense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	17120662	22534408	136604255	29	4989											
ABCA13	154664	broad.mit.edu	37	chr7	48411940	48411940	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcttggattttgggatgtCagtcgtcatgctgagctacc	6	15	11	9	1	3	1	2	1	1	0	5	3	3	3	1	2	3	2	1	2	1	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr7:48411940C>G	uc003toq.2	+	33	11004	c.10979C>G	c.(10978-10980)TCA>TGA	p.S3660*	ABCA13_uc010kys.1_Nonsense_Mutation_p.S734*|ABCA13_uc003tos.1_Nonsense_Mutation_p.S486*	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3660	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTTGGGATGTCAGTCGTCATG	0.458													83	673					0	0	0	0	G	48411940	G	G	48411940	4	3	24	1	0	0	0	0	0	1	0	0	31	838	29	2	10938	2	ABCA13	7	48411940	Nonsense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	25877532	48411940	110726723	30	4990											
SEMA3A	10371	broad.mit.edu	37	chr7	83643635	83643635	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcttcaggattgtcactctCtgagatgaggtgggcactaa	10	12	11	8	0	4	2	2	2	2	1	5	4	4	3	0	3	0	1	0	3	1	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr7:83643635C>T	uc003uhz.2	-	7	1015	c.700G>A	c.(700-702)GAG>AAG	p.E234K		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	234	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TTGTCACTCTCTGAGATGAGG	0.368													21	60					0	0	0	0	T	83643635	T	T	83643635	3	4	24	1	0	0	0	0	1	0	0	0	14089	922	32	2	1659	2	SEMA3A	7	83643635	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	35231695	83643635	75495028	31	4991											
ZNF804B	219578	broad.mit.edu	37	chr7	88965298	88965298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagtgcaattccaaggactaCggagaaagacaaaagcaaaa	20	4	9	8	1	0	2	0	0	0	2	1	4	1	3	1	2	3	2	1	2	8	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr7:88965298C>T	uc011khi.1	+	4	3540	c.3002C>T	c.(3001-3003)ACG>ATG	p.T1001M		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1001						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CCAAGGACTACGGAGAAAGAC	0.368										HNSCC(36;0.09)			29	58					0	0	0	0	T	88965298	T	T	88965298	3	4	24	1	0	0	0	0	1	0	0	0	18238	536	19	1	3016	1	ZNF804B	7	88965298	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	5321663	88965298	70173365	32	4992											
COL1A2	1278	broad.mit.edu	37	chr7	94027705	94027705	+	Frame_Shift_Del	DEL	A	-	-																															cttttctaggaaactgtaagAaaggtaagagtacactactt																										TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr7:94027705delA	uc003ung.1	+	3	564	c.93delA	c.(91-93)AGAfs	p.R31fs	COL1A2_uc011kib.1_Frame_Shift_Del_p.R31fs	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	31					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AAACTGTAAGAAAGGTAAGAG	0.234										HNSCC(75;0.22)			---	---	---								-	94027705	-	-	94027705	7	5	24	1	0	1	0	1	0	0	0	0	3693	243	9	0	103	0	COL1A2	7	94027705	Frame_Shift_Del	DEL	A	TCGA-BB-4224-01A-01D-1434-08	5062407	94027705	65110958	33	4993											
BCAP29	55973	broad.mit.edu	37	chr7	107224424	107224424	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctattgattgttctatttCtaggtaagtactagatccct	9	18	6	8	0	2	2	0	1	2	1	4	2	4	2	2	1	1	3	2	1	6	10			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr7:107224424C>T	uc003vej.2	+	3	529	c.190C>T	c.(190-192)CTA>TTA	p.L64L	BCAP29_uc011kly.1_5'UTR|BCAP29_uc011klz.1_Silent_p.L64L|BCAP29_uc011kma.1_Silent_p.L64L	NM_018844	NP_061332	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein BAP29 isoform	64	Helical; (Potential).				apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				large_intestine(1)|ovary(1)	2						TGTTCTATTTCTAGGTAAGTA	0.279													23	67					0	0	0	0	T	107224424	T	T	107224424	2	4	24	1	0	0	0	0	0	0	0	1	1348	912	32	2		2	BCAP29	7	107224424	Silent	SNP	C	TCGA-BB-4224-01A-01D-1434-08	13196719	107224424	51914239	34	4994											
CREB3L2	64764	broad.mit.edu	37	chr7	137686374	137686374	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtacatgagggcctcgccGtccccgggctctgacagctc	5	8	13	15	3	1	2	0	2	1	0	4	2	2	2	4	3	2	3	4	3	1	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr7:137686374G>C	uc003vtw.2	-	1	473	c.78C>G	c.(76-78)GAC>GAG	p.D26E	CREB3L2_uc003vtx.1_Missense_Mutation_p.D26E|CREB3L2_uc003vty.3_Missense_Mutation_p.D26E|AKR1D1_uc011kqb.1_5'Flank|AKR1D1_uc011kqc.1_5'Flank|AKR1D1_uc011kqd.1_5'Flank	NM_194071	NP_919047	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like	26	Cytoplasmic (Potential).				chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	soft_tissue(158)|upper_aerodigestive_tract(1)|ovary(1)	160						GGGCCTCGCCGTCCCCGGGCT	0.706			T	FUS	fibromyxoid sarcoma								14	39					0	0	0	0	C	137686374	C	C	137686374	3	2	24	1	0	0	0	0	1	0	0	0	3872	1136	40	3	1532	3	CREB3L2	7	137686374	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	30461950	137686374	21452289	35	4995											
LUC7L2	51631	broad.mit.edu	37	chr7	139060879	139060879	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcaccttctcaactgttgtCctcatgatgtcctttctgga	6	16	7	12	0	4	1	3	1	2	0	7	2	6	2	3	1	1	1	3	1	1	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr7:139060879C>T	uc003vux.2	+	2	507	c.133C>T	c.(133-135)CCT>TCT	p.P45S	LUC7L2_uc011kqs.1_Missense_Mutation_p.P42S|LUC7L2_uc011kqt.1_Missense_Mutation_p.P111S|LUC7L2_uc003vuy.2_Missense_Mutation_p.P44S|LUC7L2_uc003vuz.1_5'UTR|LUC7L2_uc003vva.2_5'UTR	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	45							enzyme binding|metal ion binding				0	Melanoma(164;0.242)					CAACTGTTGTCCTCATGATGT	0.338													23	67					0	0	0	0	T	139060879	T	T	139060879	3	4	24	1	0	0	0	0	1	0	0	0	9133	855	30	2	139	2	LUC7L2	7	139060879	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	1374505	139060879	20077784	36	4996											
WWP1	11059	broad.mit.edu	37	chr8	87460450	87460450	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcgtatgttaagtaaaaaacTtactattaaggatttggaat	16	14	8	3	1	0	0	0	0	0	0	0	2	0	2	0	2	2	3	0	2	9	7			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr8:87460450T>A	uc003ydt.2	+	19	2352	c.2072T>A	c.(2071-2073)CTT>CAT	p.L691H	WWP1_uc010mai.2_Missense_Mutation_p.L467H	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	691	HECT.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						AGTAAAAAACTTACTATTAAG	0.274													17	104					0	0	0	0	A	87460450	A	A	87460450	3	1	24	1	0	0	0	0	1	0	0	0	17483	1609	56	5	2138	5	WWP1	8	87460450	Missense_Mutation	SNP	T	TCGA-BB-4224-01A-01D-1434-08		87460450	58903572	37	4997											
PKHD1L1	93035	broad.mit.edu	37	chr8	110457059	110457059	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtccaatgaatttgataggcGatttgtacttttgccaaaca	12	14	8	7	1	0	2	0	2	0	0	1	3	1	2	2	1	3	1	2	1	5	6			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr8:110457059G>A	uc003yne.2	+	38	5065	c.4961G>A	c.(4960-4962)CGA>CAA	p.R1654Q		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1654	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTGATAGGCGATTTGTACTT	0.433										HNSCC(38;0.096)			187	517					0	0	0	0	A	110457059	A	A	110457059	3	1	24	1	0	0	0	0	1	0	0	0	12027	1058	37	1	5111	1	PKHD1L1	8	110457059	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	22996609	110457059	35906963	38	4998											
ADCY8	114	broad.mit.edu	37	chr8	131862050	131862050	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatggtcattggcatcactCtgcagggaaacacagaatgt	12	9	12	8	0	3	1	2	0	1	1	3	3	3	3	0	4	2	2	0	4	2	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr8:131862050C>T	uc003ytd.3	-	10	2467	c.2211_splice	c.e10-1	p.R737_splice	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TGGCATCACTCTGCAGGGAAA	0.468										HNSCC(32;0.087)			3	46					0	0	0	0	T	131862050	T	T	131862050	5	4	24	1	0	0	0	0	0	0	1	0	300	927	32	2	1581	2	ADCY8	8	131862050	Splice_Site	SNP	C	TCGA-BB-4224-01A-01D-1434-08	21404991	131862050	14501972	39	4999											
EIF2C2	27161	broad.mit.edu	37	chr8	141557665	141557665	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcgtggtcctctgcacgttCttcatctgcacgcactgcgt	4	12	11	14	4	4	0	1	0	3	0	5	0	5	0	1	2	3	4	1	2	0	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr8:141557665C>G	uc003yvn.2	-	13	1690	c.1650G>C	c.(1648-1650)AAG>AAC	p.K550N	EIF2C2_uc010men.2_Missense_Mutation_p.K473N|EIF2C2_uc010meo.2_Missense_Mutation_p.K550N	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	550	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			TCTGCACGTTCTTCATCTGCA	0.627													44	117					0	0	0	0	G	141557665	G	G	141557665	3	3	24	1	0	0	0	0	1	0	0	0	5028	912	32	2	957	2	EIF2C2	8	141557665	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	9695615	141557665	4806357	40	5000											
NAPRT1	93100	broad.mit.edu	37	chr8	144659233	144659233	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtttagaggagggactgaccGggtcagggggcacctcgctg	7	7	18	9	2	1	2	1	1	0	1	2	4	1	4	2	5	0	3	2	5	1	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr8:144659233G>A	uc003yym.3	-	5	708	c.683C>T	c.(682-684)CCG>CTG	p.P228L	NAPRT1_uc003yyn.3_Missense_Mutation_p.P228L|NAPRT1_uc011lkh.1_Missense_Mutation_p.P228L|NAPRT1_uc003yyo.3_Missense_Mutation_p.P228L	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	228					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GGGACTGACCGGGTCAGGGGG	0.677													7	82					0	0	0	0	A	144659233	A	A	144659233	3	1	24	1	0	0	0	0	1	0	0	0	10218	1130	39	1	969	1	NAPRT1	8	144659233	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	3101568	144659233	1704789	41	5001											
KIAA1161	57462	broad.mit.edu	37	chr9	34371689	34371689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcaccagcgcaggtaacCggcccgtgggttcgcgcacg	7	4	15	15	7	0	0	0	0	0	0	1	0	0	0	3	3	3	5	3	3	1	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr9:34371689C>T	uc003zue.3	-	3	1420	c.1253G>A	c.(1252-1254)CGG>CAG	p.R418Q		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	418	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CGCAGGTAACCGGCCCGTGGG	0.672													5	25					0	0	0	0	T	34371689	T	T	34371689	3	4	24	1	0	0	0	0	1	0	0	0	8250	652	23	1	895	1	KIAA1161	9	34371689	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08		34371689	106841742	42	5002											
TRPM6	140803	broad.mit.edu	37	chr9	77377269	77377269	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgatcttggcttgggaaaGaggggagctcattgtcatgg	9	11	15	6	0	3	2	2	1	1	1	3	4	3	4	0	5	1	2	0	5	1	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr9:77377269G>A	uc004ajl.1	-	26	4556	c.4318C>T	c.(4318-4320)CTT>TTT	p.L1440F	TRPM6_uc004ajk.1_Missense_Mutation_p.L1435F|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.L396F	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1440	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GCTTGGGAAAGAGGGGAGCTC	0.473													44	207					0	0	0	0	A	77377269	A	A	77377269	3	1	24	1	0	0	0	0	1	0	0	0	16657	942	33	2	1806	2	TRPM6	9	77377269	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	43005580	77377269	63836162	43	5003											
ZNF169	169841	broad.mit.edu	37	chr9	97062822	97062822	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggagtgtgggcgaggctttCgccagaagatagccctcctt	8	9	14	10	2	0	2	0	0	0	2	2	4	1	3	3	3	1	1	3	3	2	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr9:97062822C>T	uc004aum.1	+	5	1087	c.982C>T	c.(982-984)CGC>TGC	p.R328C		NM_194320	NP_919301	Q14929	ZN169_HUMAN	zinc finger protein 169	328	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				GCGAGGCTTTCGCCAGAAGAT	0.542													45	269					0	0	0	0	T	97062822	T	T	97062822	3	4	24	1	0	0	0	0	1	0	0	0	17809	884	31	1	996	1	ZNF169	9	97062822	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	19685553	97062822	44150609	44	5004											
ZNF510	22869	broad.mit.edu	37	chr9	99521950	99521950	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgaactctgtgaaccgacgTctggtaggatttcttatttt	8	15	10	8	3	3	1	0	1	3	0	3	4	3	2	1	2	2	1	1	2	4	5			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr9:99521950T>A	uc004awn.1	-	6	1351	c.1162A>T	c.(1162-1164)ACG>TCG	p.T388S	ZNF510_uc004awo.1_Missense_Mutation_p.T388S	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				TGAACCGACGTCTGGTAGGAT	0.393													82	445					0	0	0	0	A	99521950	A	A	99521950	3	1	24	1	0	0	0	0	1	0	0	0	18021	1667	58	5	893	5	ZNF510	9	99521950	Missense_Mutation	SNP	T	TCGA-BB-4224-01A-01D-1434-08	2459128	99521950	41691481	45	5005											
NANS	54187	broad.mit.edu	37	chr9	100845233	100845233	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaaggctatcctcctgaaGacatctttaatctagtgggc	11	11	8	11	0	2	2	0	1	2	1	4	2	4	2	3	2	0	1	3	2	5	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr9:100845233G>A	uc004ayb.2	+	7	1618	c.976G>A	c.(976-978)GAC>AAC	p.D326N	NANS_uc004ayc.2_Missense_Mutation_p.D326N|TRIM14_uc004ayd.2_Intron|TRIM14_uc004ayf.1_Intron	NM_018946	NP_061819	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid phosphate synthase	326	AFP-like.				lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				TCCTCCTGAAGACATCTTTAA	0.458													24	125					0	0	0	0	A	100845233	A	A	100845233	3	1	24	1	0	0	0	0	1	0	0	0	10208	942	33	2	998	2	NANS	9	100845233	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	1323283	100845233	40368198	46	5006											
OR13C4	138804	broad.mit.edu	37	chr9	107288872	107288872	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacgagcagaggaagaactaGgaaagcaatatttgacactg	17	6	11	7	1	0	3	0	1	0	2	0	6	0	5	0	2	3	2	0	2	6	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr9:107288872G>T	uc011lvn.1	-	1	619	c.619C>A	c.(619-621)CTA>ATA	p.L207I		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGAAGAACTAGGAAAGCAATA	0.383													64	137					1.48873e-21	1.68811e-21	1	0	T	107288872	T	T	107288872	3	4	24	1	0	0	0	0	1	0	0	0	10990	991	35	4	339	4	OR13C4	9	107288872	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	6443639	107288872	33924559	47	5007											
ENTPD8	377841	broad.mit.edu	37	chr9	140332687	140332687	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgtgaggcctgagaccccCgaggcccccagcagggccaa	8	2	14	17	2	0	2	0	2	0	1	0	4	0	2	7	3	1	1	7	3	1	0			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr9:140332687C>T	uc004cmw.2	-	2	235	c.51G>A	c.(49-51)TCG>TCA	p.S17S	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Silent_p.S17S|ENTPD8_uc004cmy.2_Silent_p.S17S	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	17	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		CTGAGACCCCCGAGGCCCCCA	0.697													6	27					0	0	0	0	T	140332687	T	T	140332687	2	4	24	1	0	0	0	0	0	0	0	1	5169	639	23	1		1	ENTPD8	9	140332687	Silent	SNP	C	TCGA-BB-4224-01A-01D-1434-08	33043815	140332687	880744	48	5008											
ZMYND11	10771	broad.mit.edu	37	chr10	294288	294288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttttaggaaccagagcctGaaacagaagcagtaagttct	14	9	9	9	0	1	3	0	1	1	2	1	4	1	4	3	1	4	3	3	1	5	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr10:294288G>A	uc010pzt.1	+	13	1668	c.1240G>A	c.(1240-1242)GAA>AAA	p.E414K	ZMYND11_uc001ifk.2_Missense_Mutation_p.E413K|ZMYND11_uc010pzu.1_Missense_Mutation_p.E414K|ZMYND11_uc010pzv.1_Missense_Mutation_p.E359K|ZMYND11_uc010pzw.1_Missense_Mutation_p.E329K|ZMYND11_uc001ifm.2_Missense_Mutation_p.E360K|ZMYND11_uc010pzx.1_Missense_Mutation_p.E414K|ZMYND11_uc001ifn.2_Missense_Mutation_p.E360K|ZMYND11_uc009xhg.2_Missense_Mutation_p.E397K|ZMYND11_uc009xhh.2_Missense_Mutation_p.E288K|ZMYND11_uc010pzy.1_Missense_Mutation_p.E266K	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	374					cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		ACCAGAGCCTGAAACAGAAGC	0.448													51	129					0	0	0	0	A	294288	A	A	294288	3	1	24	1	0	0	0	0	1	0	0	0	17773	1291	45	2	1286	2	ZMYND11	10	294288	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08		294288	135240459	49	5009											
SFMBT2	57713	broad.mit.edu	37	chr10	7239538	7239538	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaccagcacgcatttgcccGgtcccaccgactgaggtagc	9	6	11	15	3	0	1	0	1	0	0	1	3	1	1	4	2	4	3	4	2	2	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr10:7239538G>A	uc009xio.1	-	15	1761	c.1670C>T	c.(1669-1671)CCG>CTG	p.P557L	SFMBT2_uc001ijn.1_Missense_Mutation_p.P557L|SFMBT2_uc010qay.1_Intron	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	557					regulation of transcription, DNA-dependent	nucleus		p.P557P(1)		ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						GCATTTGCCCGGTCCCACCGA	0.478													25	90					0	0	0	0	A	7239538	A	A	7239538	3	1	24	1	0	0	0	0	1	0	0	0	14223	1116	39	1	1042	1	SFMBT2	10	7239538	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	6945250	7239538	128295209	50	5010											
CTNNA3	29119	broad.mit.edu	37	chr10	68280411	68280411	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcatcaatgcttgtaatgtCatctacggcttcagtgagga	10	13	10	8	1	5	1	4	1	1	0	5	2	5	2	0	2	2	3	0	2	3	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr10:68280411C>T	uc009xpn.1	-	11	1618	c.1495G>A	c.(1495-1497)GAC>AAC	p.D499N	CTNNA3_uc001jmw.2_Missense_Mutation_p.D499N|CTNNA3_uc001jmx.3_Missense_Mutation_p.D499N	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	499					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CTTGTAATGTCATCTACGGCT	0.343													39	118					0	0	0	0	T	68280411	T	T	68280411	3	4	24	1	0	0	0	0	1	0	0	0	4031	826	29	2	1224	2	CTNNA3	10	68280411	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	61040873	68280411	67254336	51	5011											
USP54	159195	broad.mit.edu	37	chr10	75279642	75279642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgattgctgctgctgcatgCgatcctgcaggctccgtgct	4	12	13	12	2	0	1	0	1	0	0	2	2	2	1	2	1	7	7	2	1	0	1	rs143471997	by1000genomes	TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr10:75279642C>T	uc001juo.2	-	17	2608	c.2591G>A	c.(2590-2592)CGC>CAC	p.R864H	USP54_uc010qkk.1_Missense_Mutation_p.R46H|USP54_uc001juk.2_Intron|USP54_uc001jul.2_Intron|USP54_uc001jum.2_Intron|USP54_uc001jun.2_Intron|USP54_uc001jup.2_Missense_Mutation_p.R864H	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	864					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					CTGCTGCATGCGATCCTGCAG	0.577													3	40					0	0	0	0	T	75279642	T	T	75279642	3	4	24	1	0	0	0	0	1	0	0	0	17153	768	27	1	2487	1	USP54	10	75279642	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	6999231	75279642	60255105	52	5012											
ATHL1	80162	broad.mit.edu	37	chr11	294141	294141	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcaggcgctgtgaacttcCtgacaggcatggggggcttc	6	9	16	10	1	1	2	1	2	0	0	3	2	2	2	1	6	1	3	1	6	1	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr11:294141C>T	uc010qvu.1	+	12	1868	c.1753C>T	c.(1753-1755)CTG>TTG	p.L585L	ATHL1_uc001lor.3_Silent_p.L337L|ATHL1_uc001lou.3_Silent_p.L160L|ATHL1_uc001lov.3_Silent_p.L46L	NM_025092	NP_079368	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1	585					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			liver(1)|central_nervous_system(1)|skin(1)	3		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		TGTGAACTTCCTGACAGGCAT	0.667													33	98					0	0	0	0	T	294141	T	T	294141	2	4	24	1	0	0	0	0	0	0	0	1	1106	680	24	4		4	ATHL1	11	294141	Silent	SNP	C	TCGA-BB-4224-01A-01D-1434-08		294141	134712375	53	5013											
AP2A2	161	broad.mit.edu	37	chr11	988626	988626	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgaccgcagcaacgccccAcagatcgtggccgagatgct	9	5	12	15	5	0	2	0	0	0	2	1	4	0	2	4	1	4	3	4	1	1	0			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr11:988626A>T	uc001lss.2	+	10	1387	c.1206A>T	c.(1204-1206)CCA>CCT	p.P402P	AP2A2_uc001lst.1_Silent_p.P403P|AP2A2_uc009yco.1_RNA	NM_012305	NP_036437	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2	402					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCAACGCCCCACAGATCGTGG	0.607													43	112					0	0	0	0	T	988626	T	T	988626	2	4	24	1	0	0	0	0	0	0	0	1	740	146	6	5		5	AP2A2	11	988626	Silent	SNP	A	TCGA-BB-4224-01A-01D-1434-08	694485	988626	134017890	54	5014											
AMBRA1	55626	broad.mit.edu	37	chr11	46419246	46419246	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctctgccagttgcccggcCtctgggagcagtccccgaga	5	7	13	16	3	2	1	0	0	2	1	3	3	3	2	5	2	3	3	5	2	0	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr11:46419246C>A	uc010rgu.1	-	18	4011	c.3651G>T	c.(3649-3651)GAG>GAT	p.E1217D	AMBRA1_uc010rgt.1_3'UTR|AMBRA1_uc009ylc.1_Missense_Mutation_p.E1188D|AMBRA1_uc001ncu.1_Missense_Mutation_p.E1127D|AMBRA1_uc001ncv.2_Missense_Mutation_p.E1220D|AMBRA1_uc001ncw.2_Missense_Mutation_p.E1098D|AMBRA1_uc001ncx.2_Missense_Mutation_p.E1157D	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	1217					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		GTTGCCCGGCCTCTGGGAGCA	0.687													24	251					3.7963e-18	4.26664e-18	1	0	A	46419246	A	A	46419246	3	1	24	1	0	0	0	0	1	0	0	0	565	680	24	4	249	4	AMBRA1	11	46419246	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	45430620	46419246	88587270	55	5015											
LRP4	4038	broad.mit.edu	37	chr11	46898081	46898081	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgccacaccaacactttccGcatggacccgtccaggttgc	8	8	8	17	2	0	0	0	0	0	0	2	1	2	1	5	2	3	2	5	2	1	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr11:46898081G>A	uc001ndn.3	-	25	3618	c.3472C>T	c.(3472-3474)CGG>TGG	p.R1158W		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1158	Extracellular (Potential).|LDL-receptor class B 12.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		AACACTTTCCGCATGGACCCG	0.577													63	298					0	0	0	0	A	46898081	A	A	46898081	3	1	24	1	0	0	0	0	1	0	0	0	9009	1086	38	1	2301	1	LRP4	11	46898081	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	478835	46898081	88108435	56	5016											
BSCL2	26580	broad.mit.edu	37	chr11	62457910	62457910	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagctgcccagagtctctaGgacaggggcagaagcagaag	13	4	15	9	0	1	4	0	0	1	4	2	5	1	5	1	3	3	3	1	3	3	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr11:62457910G>A	uc001nuo.1	-	11	1550	c.1126C>T	c.(1126-1128)CTA>TTA	p.L376L	LRRN4CL_uc001nun.2_5'Flank|BSCL2_uc009yoc.1_3'UTR|BSCL2_uc001nup.2_Silent_p.L376L|BSCL2_uc001nuq.1_Silent_p.L376L|BSCL2_uc001nur.3_Silent_p.L440L|BSCL2_uc009yod.2_Silent_p.L440L|BSCL2_uc001nut.3_Silent_p.L442L|HNRNPUL2_uc001nuu.1_RNA	NM_032667	NP_116056	Q96G97	BSCL2_HUMAN	seipin isoform 2	376	Cytoplasmic (Potential).				cell death	integral to endoplasmic reticulum membrane					0						AGAGTCTCTAGGACAGGGGCA	0.607													22	80					0	0	0	0	A	62457910	A	A	62457910	2	1	24	1	0	0	0	0	0	0	0	1	1532	991	35	4		4	BSCL2	11	62457910	Silent	SNP	G	TCGA-BB-4224-01A-01D-1434-08	15559829	62457910	72548606	57	5017											
ESRRA	2101	broad.mit.edu	37	chr11	64074712	64074712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcagagccggccagccctGacagtccaaagggttcctcg	9	5	13	14	2	0	2	0	1	0	1	3	2	2	2	5	3	2	2	5	3	1	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr11:64074712G>A	uc001nzq.1	+	2	238	c.61G>A	c.(61-63)GAC>AAC	p.D21N	ESRRA_uc001nzr.1_Missense_Mutation_p.D21N|ESRRA_uc001nzs.1_Missense_Mutation_p.D21N	NM_004451	NP_004442	P11474	ERR1_HUMAN	estrogen-related receptor alpha	21	Repressor domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0						GGCCAGCCCTGACAGTCCAAA	0.642													21	55					0	0	0	0	A	64074712	A	A	64074712	3	1	24	1	0	0	0	0	1	0	0	0	5284	1290	45	2	63	2	ESRRA	11	64074712	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	1616802	64074712	70931804	58	5018											
IGHMBP2	3508	broad.mit.edu	37	chr11	68696768	68696768	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccccctgctgaaggccaGaaagtgcatcctggcgggcg	8	6	14	13	2	0	2	0	1	0	1	2	3	2	2	4	3	2	2	4	3	2	0			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr11:68696768G>T	uc001ook.1	+	8	1280	c.1178G>T	c.(1177-1179)AGA>ATA	p.R393I	IGHMBP2_uc001ooj.1_RNA|IGHMBP2_uc001ool.1_5'Flank	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	393	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTGAAGGCCAGAAAGTGCATC	0.627													26	106					4.87955e-14	5.34227e-14	1	0	T	68696768	T	T	68696768	3	4	24	1	0	0	0	0	1	0	0	0	7630	942	33	2	1208	2	IGHMBP2	11	68696768	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	4622056	68696768	66309748	59	5019											
RSF1	51773	broad.mit.edu	37	chr11	77394814	77394814	+	Frame_Shift_Del	DEL	T	-	-																															tcaagcaagtttgctttggaTttttttgaatcttttttctt																										TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr11:77394814delT	uc001oyn.2	-	11	3126	c.3006delA	c.(3004-3006)AAAfs	p.K1002fs	RSF1_uc001oym.2_Frame_Shift_Del_p.K750fs	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	1002	Potential.				CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			TTGCTTTGGATTTTTTTGAAT	0.323													---	---	---								-	77394814	-	-	77394814	7	5	24	1	0	1	0	1	0	0	0	0	13764	1490	52	0	1343	0	RSF1	11	77394814	Frame_Shift_Del	DEL	T	TCGA-BB-4224-01A-01D-1434-08	8698046	77394814	57611702	60	5020											
REXO2	25996	broad.mit.edu	37	chr11	114314649	114314649	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattggtgtaaggagcatcaCgggaaggtaacattaccaaa	15	8	12	6	1	1	0	1	0	0	0	1	3	1	2	1	4	3	3	1	4	5	4	rs151260750		TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr11:114314649C>T	uc001poy.2	+	3	446	c.303C>T	c.(301-303)CAC>CAT	p.H101H	REXO2_uc001poz.2_Intron	NM_015523	NP_056338	Q9Y3B8	ORN_HUMAN	small fragment nuclease precursor	101	Exonuclease.				nucleotide metabolic process	mitochondrion|nucleus	3'-5' exonuclease activity|nucleic acid binding				0		all_cancers(61;5.06e-12)|all_epithelial(67;5.3e-06)|all_hematologic(158;7.68e-05)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.65e-06)|Epithelial(105;6.09e-05)|all cancers(92;0.000494)		AGGAGCATCACGGGAAGGTAA	0.458													4	9					0	0	0	0	T	114314649	T	T	114314649	2	4	24	1	0	0	0	0	0	0	0	1	13307	535	19	1		1	REXO2	11	114314649	Silent	SNP	C	TCGA-BB-4224-01A-01D-1434-08	36919835	114314649	20691867	61	5021											
TAS2R50	259296	broad.mit.edu	37	chr12	11138842	11138842	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatggagctgcatcttcttGagatgtttacacagagaaca	12	11	9	9	0	2	2	0	1	2	2	2	5	2	3	1	1	4	3	1	1	2	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr12:11138842G>C	uc001qzl.2	-	1	670	c.618C>G	c.(616-618)CTC>CTG	p.L206L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	206	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						GCATCTTCTTGAGATGTTTAC	0.418													58	351					0	0	0	0	C	11138842	C	C	11138842	2	2	24	1	0	0	0	0	0	0	0	1	15650	1277	45	2		2	TAS2R50	12	11138842	Silent	SNP	G	TCGA-BB-4224-01A-01D-1434-08		11138842	122713053	62	5022											
C12orf60	144608	broad.mit.edu	37	chr12	14976229	14976229	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtattcaaaagtgcccatacGccagtcatcatctctgtgct	10	12	7	12	1	4	0	3	0	1	0	5	0	4	0	2	0	3	2	2	0	4	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr12:14976229G>A	uc001rcj.3	+	2	564	c.360G>A	c.(358-360)ACG>ACA	p.T120T		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	120										ovary(1)|central_nervous_system(1)	2						GTGCCCATACGCCAGTCATCA	0.428													45	326					0	0	0	0	A	14976229	A	A	14976229	2	1	24	1	0	0	0	0	0	0	0	1	1709	1074	38	1		1	C12orf60	12	14976229	Silent	SNP	G	TCGA-BB-4224-01A-01D-1434-08	3837387	14976229	118875666	63	5023											
IRAK4	51135	broad.mit.edu	37	chr12	44177513	44177513	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctgtggatgaacaccgtGaacctcagttattggtaaat	12	11	10	8	1	1	2	1	2	0	0	1	3	1	3	2	2	3	3	2	2	5	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr12:44177513G>T	uc001rnu.3	+	11	1304	c.1174G>T	c.(1174-1176)GAA>TAA	p.E392*	IRAK4_uc001rnt.3_Nonsense_Mutation_p.E392*|IRAK4_uc001rnx.3_Nonsense_Mutation_p.E268*|IRAK4_uc001rny.3_Nonsense_Mutation_p.E268*|IRAK4_uc010sky.1_Nonsense_Mutation_p.E268*|IRAK4_uc001rnv.3_Nonsense_Mutation_p.E268*|IRAK4_uc001rnw.3_Nonsense_Mutation_p.E268*	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	392	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		TGAACACCGTGAACCTCAGTT	0.264													12	20					0.000151284	0.000157485	1	0	T	44177513	T	T	44177513	4	4	24	1	0	0	0	0	0	1	0	0	7864	1291	45	2	1208	2	IRAK4	12	44177513	Nonsense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	29201284	44177513	89674382	64	5024											
GPR182	11318	broad.mit.edu	37	chr12	57389924	57389924	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcattgactgcttctccatgCtgcactgtgtcatcaacccc	7	13	6	15	0	4	1	3	1	1	0	5	1	4	1	3	0	4	3	3	0	1	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr12:57389924C>G	uc001smk.2	+	2	1025	c.931C>G	c.(931-933)CTG>GTG	p.L311V	RDH16_uc010sqx.1_Intron	NM_007264	NP_009195	O15218	GP182_HUMAN	G protein-coupled receptor 182	311	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(1)	1						CTTCTCCATGCTGCACTGTGT	0.542													10	415					0	0	0	0	G	57389924	G	G	57389924	3	3	24	1	0	0	0	0	1	0	0	0	6715	796	28	4	933	4	GPR182	12	57389924	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	13212411	57389924	76461971	65	5025											
CHST11	50515	broad.mit.edu	37	chr12	105150982	105150982	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatggagatcccggccaacGaggcacacgtctccgccaac	10	4	10	17	4	1	1	0	0	1	1	3	3	2	1	5	3	2	1	5	3	2	0			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr12:105150982G>A	uc001tkx.1	+	4	751	c.460G>A	c.(460-462)GAG>AAG	p.E154K	CHST11_uc001tky.2_Missense_Mutation_p.E149K|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	154	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						CCCGGCCAACGAGGCACACGT	0.587													20	74					0	0	0	0	A	105150982	A	A	105150982	3	1	24	1	0	0	0	0	1	0	0	0	3414	1059	37	1	470	1	CHST11	12	105150982	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	47761058	105150982	28700913	66	5026											
CUX2	23316	broad.mit.edu	37	chr12	111744814	111744814	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctgcggctgctgaaggaCgtgcagcacctccagagctc	8	7	12	14	2	0	2	0	1	0	1	3	3	2	3	3	2	5	5	3	2	1	0			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr12:111744814C>T	uc001tsa.1	+	11	1101	c.948C>T	c.(946-948)GAC>GAT	p.D316D		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	316	Potential.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TGCTGAAGGACGTGCAGCACC	0.647													24	66					0	0	0	0	T	111744814	T	T	111744814	2	4	24	1	0	0	0	0	0	0	0	1	4082	535	19	1		1	CUX2	12	111744814	Silent	SNP	C	TCGA-BB-4224-01A-01D-1434-08	6593832	111744814	22107081	67	5027											
PCDH17	27253	broad.mit.edu	37	chr13	58208360	58208360	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctaaggactcgggggcgccCgcgcacttggagagcaacgc	8	4	16	13	5	0	1	0	0	0	1	1	3	0	2	1	4	2	3	1	4	2	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr13:58208360C>T	uc001vhq.1	+	1	2572	c.1680C>T	c.(1678-1680)CCC>CCT	p.P560P	PCDH17_uc010aec.1_Silent_p.P560P	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	560	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CGGGGGCGCCCGCGCACTTGG	0.607													21	42					0	0	0	0	T	58208360	T	T	58208360	2	4	24	1	0	0	0	0	0	0	0	1	11566	639	23	1		1	PCDH17	13	58208360	Silent	SNP	C	TCGA-BB-4224-01A-01D-1434-08		58208360	56961518	68	5028											
HEATR4	399671	broad.mit.edu	37	chr14	73978743	73978743	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggtggcaatccggggccGttccaaagcagctgtggcac	7	7	15	12	2	0	0	0	0	0	0	2	0	2	0	3	5	2	6	3	5	2	1	rs139427381	byFrequency	TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr14:73978743G>A	uc010tub.1	-	7	1847	c.1525C>T	c.(1525-1527)CGG>TGG	p.R509W	HEATR4_uc010tua.1_Missense_Mutation_p.R462W	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		ATCCGGGGCCGTTCCAAAGCA	0.458													30	126					0	0	0	0	A	73978743	A	A	73978743	3	1	24	1	0	0	0	0	1	0	0	0	7069	1144	40	1	1603	1	HEATR4	14	73978743	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08		73978743	33370797	69	5029											
DYNC1H1	1778	broad.mit.edu	37	chr14	102478730	102478730	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtggatccagagtgggttGagaacttgaactcagtgctg	10	11	14	6	0	1	3	1	2	0	2	2	5	2	4	1	2	3	2	1	2	2	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr14:102478730G>A	uc001yks.2	+	34	7101	c.6937G>A	c.(6937-6939)GAG>AAG	p.E2313K	DYNC1H1_uc001ykt.1_5'Flank	NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2313	AAA 2 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						AGAGTGGGTTGAGAACTTGAA	0.502													59	101					0	0	0	0	A	102478730	A	A	102478730	3	1	24	1	0	0	0	0	1	0	0	0	4863	1291	45	2	7071	2	DYNC1H1	14	102478730	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	28499987	102478730	4870810	70	5030											
DYNC1H1	1778	broad.mit.edu	37	chr14	102504839	102504839	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgaacccggtgctgaacCgtgaagtgcggcgaacaggg	9	8	15	9	4	0	3	0	3	0	0	0	4	0	3	2	3	5	1	2	3	4	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr14:102504839C>T	uc001yks.2	+	58	11115	c.10951C>T	c.(10951-10953)CGT>TGT	p.R3651C		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3651	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GGTGCTGAACCGTGAAGTGCG	0.547													17	46					0	0	0	0	T	102504839	T	T	102504839	3	4	24	1	0	0	0	0	1	0	0	0	4863	652	23	1	11181	1	DYNC1H1	14	102504839	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	26109	102504839	4844701	71	5031											
SQRDL	58472	broad.mit.edu	37	chr15	45981253	45981253	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagtatgatggctacacatCatgtccactggtgaccggct	9	12	10	10	1	1	2	1	2	0	0	2	2	2	2	2	3	1	3	2	3	3	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr15:45981253C>G	uc001zvt.2	+	10	1322	c.1133C>G	c.(1132-1134)TCA>TGA	p.S378*	SQRDL_uc001zvu.2_Nonsense_Mutation_p.S378*|SQRDL_uc001zvv.2_Nonsense_Mutation_p.S378*	NM_021199	NP_067022	Q9Y6N5	SQRD_HUMAN	sulfide dehydrogenase like precursor	378							oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		GGCTACACATCATGTCCACTG	0.393													52	224					0	0	0	0	G	45981253	G	G	45981253	4	3	24	1	0	0	0	0	0	1	0	0	15195	838	29	2	1163	2	SQRDL	15	45981253	Nonsense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08		45981253	56550139	72	5032											
ATP8B4	79895	broad.mit.edu	37	chr15	50223420	50223420	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttatggtctctggggtcCgggatttaaaaatgaaccca	10	13	11	7	1	1	1	0	1	1	0	3	2	2	2	2	4	1	1	2	4	5	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr15:50223420C>T	uc001zxu.2	-	16	1680	c.1538G>A	c.(1537-1539)CGG>CAG	p.R513Q	ATP8B4_uc010ber.2_Missense_Mutation_p.R386Q|ATP8B4_uc010ufd.1_Intron|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	513	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CTCTGGGGTCCGGGATTTAAA	0.398													41	98					0	0	0	0	T	50223420	T	T	50223420	3	4	24	1	0	0	0	0	1	0	0	0	1199	652	23	1	2092	1	ATP8B4	15	50223420	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	4242167	50223420	52307972	73	5033											
AKAP13	11214	broad.mit.edu	37	chr15	86283474	86283474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggttgtccagagcgttgttCatctctacgagctcctcagc	7	12	10	12	2	3	1	2	0	1	1	6	2	5	1	2	1	4	4	2	1	1	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr15:86283474C>T	uc002blv.1	+	34	7749	c.7579C>T	c.(7579-7581)CAT>TAT	p.H2527Y	AKAP13_uc002blu.1_Missense_Mutation_p.H2531Y|AKAP13_uc002blw.1_Missense_Mutation_p.H992Y|AKAP13_uc002blx.1_Missense_Mutation_p.H772Y	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2527	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GAGCGTTGTTCATCTCTACGA	0.468													23	68					0	0	0	0	T	86283474	T	T	86283474	3	4	24	1	0	0	0	0	1	0	0	0	449	826	29	2	7779	2	AKAP13	15	86283474	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	36060054	86283474	16247918	74	5034											
PDXDC1	23042	broad.mit.edu	37	chr16	15103580	15103580	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgattaaagatgatatagagCgaggaagactgcccctgttg	13	10	12	6	1	0	5	0	2	0	3	0	7	0	6	2	1	2	1	2	1	5	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr16:15103580C>G	uc002dda.3	+	8	915	c.691C>G	c.(691-693)CGA>GGA	p.R231G	PDXDC1_uc010uzl.1_Missense_Mutation_p.R216G|PDXDC1_uc010uzm.1_Missense_Mutation_p.R140G|PDXDC1_uc002dcz.2_Missense_Mutation_p.R208G|PDXDC1_uc002ddb.3_Missense_Mutation_p.R204G|PDXDC1_uc010uzn.1_Missense_Mutation_p.R203G|PDXDC1_uc002ddc.2_Missense_Mutation_p.R231G	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	231					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	TGATATAGAGCGAGGAAGACT	0.418													42	163					0	0	0	0	G	15103580	G	G	15103580	3	3	24	1	0	0	0	0	1	0	0	0	11750	760	27	3	721	3	PDXDC1	16	15103580	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08		15103580	75251173	75	5035											
ARHGAP17	55114	broad.mit.edu	37	chr16	24988544	24988544	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgatactcacgtgtctccTctcggcatcggtgccatgct	5	13	9	14	3	4	1	1	1	3	0	7	1	4	1	2	2	3	2	2	2	1	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr16:24988544T>G	uc002dnb.2	-	3	283	c.190A>C	c.(190-192)AGG>CGG	p.R64R	ARHGAP17_uc002dnc.2_Silent_p.R64R|ARHGAP17_uc010vcf.1_Intron|ARHGAP17_uc002dng.1_Silent_p.R64R	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	64	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		ACGTGTCTCCTCTCGGCATCG	0.547													38	42					0	0	0	0	G	24988544	G	G	24988544	2	3	24	1	0	0	0	0	0	0	0	1	867	1550	54	5		5	ARHGAP17	16	24988544	Silent	SNP	T	TCGA-BB-4224-01A-01D-1434-08	9884964	24988544	65366209	76	5036											
SRCAP	10847	broad.mit.edu	37	chr16	30736322	30736322	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgcgctctggtccccccagCcctccctccactgctacctc	3	10	6	22	1	1	0	0	0	1	0	5	0	4	0	7	1	4	2	7	1	1	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr16:30736322C>T	uc002dze.1	+	25	5962	c.5577C>T	c.(5575-5577)AGC>AGT	p.S1859S	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.S1654S|SRCAP_uc010bzz.1_Silent_p.S1429S	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1859	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GTCCCCCCAGCCCTCCCTCCA	0.612													125	132					0	0	0	0	T	30736322	T	T	30736322	2	4	24	1	0	0	0	0	0	0	0	1	15201	738	26	4		4	SRCAP	16	30736322	Silent	SNP	C	TCGA-BB-4224-01A-01D-1434-08	5747778	30736322	59618431	77	5037											
ADAMTS18	170692	broad.mit.edu	37	chr16	77465453	77465453	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccgttgtgcaaaatgtcGtgtgaaatatatgacccggc	10	11	11	9	3	0	2	0	2	0	0	1	2	0	2	2	1	2	2	2	1	5	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr16:77465453G>A	uc002ffc.3	-	3	653	c.234C>T	c.(232-234)CAC>CAT	p.H78H	ADAMTS18_uc002ffe.1_Translation_Start_Site|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	78					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GCAAAATGTCGTGTGAAATAT	0.488													101	418					0	0	0	0	A	77465453	A	A	77465453	2	1	24	1	0	0	0	0	0	0	0	1	263	1136	40	1		1	ADAMTS18	16	77465453	Silent	SNP	G	TCGA-BB-4224-01A-01D-1434-08	46729131	77465453	12889300	78	5038											
PKD1L2	114780	broad.mit.edu	37	chr16	81142864	81142864	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccgcatcaaagagggtttTgtaggaacggagtttccaac	11	9	12	9	3	1	1	1	0	0	1	2	3	2	3	2	3	2	4	2	3	4	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr16:81142864T>C	uc002fgh.1	-	43	7021	c.7021A>G	c.(7021-7023)AAA>GAA	p.K2341E	PKD1L2_uc002fgf.1_Missense_Mutation_p.K141E|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2341	Channel pore-region.|Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AAGAGGGTTTTGTAGGAACGG	0.458													3	19					0	0	0	0	C	81142864	C	C	81142864	3	2	24	1	0	0	0	0	1	0	0	0	12020	1821	63	5	370	5	PKD1L2	16	81142864	Missense_Mutation	SNP	T	TCGA-BB-4224-01A-01D-1434-08	3677411	81142864	9211889	79	5039											
KCTD11	147040	broad.mit.edu	37	chr17	7256193	7256193	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccctcctttgggggccccGtgaccctgaatgtggggggc	3	8	15	15	1	0	2	0	2	0	0	1	2	1	2	6	5	0	0	6	5	1	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr17:7256193G>A	uc002gge.3	+	1	986	c.-68G>A	c.(-70--66)CCGTG>CCATG		TMEM95_uc002ggf.1_5'Flank|TMEM95_uc002ggg.1_5'Flank|TMEM95_uc002ggh.1_5'Flank	NM_001002914	NP_001002914	Q693B1	KCD11_HUMAN	potassium channel tetramerisation domain						cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Prostate(122;0.157)				TGGGGGCCCCGTGACCCTGAA	0.582													36	31					0	0	0	0	A	7256193	A	A	7256193	1	1	24	1	0	0	0	0	0	0	0	0	8137	1160	40	1		1	KCTD11	17	7256193	Translation_Start_Site	SNP	G	TCGA-BB-4224-01A-01D-1434-08		7256193	73939017	80	5040											
TP53	7157	broad.mit.edu	37	chr17	7578192	7578193	+	Frame_Shift_Del	DEL	GG	-	-																															cagacctcaggcggctcataGggcaccaccacactatgtcg																										TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr17:7578192_7578193delGG	uc002gim.2	-	6	850_851	c.656_657delCC	c.(655-657)CCCfs	p.P219fs	TP53_uc002gig.1_Frame_Shift_Del_p.P219fs|TP53_uc002gih.2_Frame_Shift_Del_p.P219fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.P87fs|TP53_uc010cng.1_Frame_Shift_Del_p.P87fs|TP53_uc002gii.1_Frame_Shift_Del_p.P87fs|TP53_uc010cnh.1_Frame_Shift_Del_p.P219fs|TP53_uc010cni.1_Frame_Shift_Del_p.P219fs|TP53_uc002gij.2_Frame_Shift_Del_p.P219fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.P126fs|TP53_uc002gio.2_Frame_Shift_Del_p.P87fs|TP53_uc010vug.1_Frame_Shift_Del_p.P180fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	219	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> R (in a sporadic cancer; somatic mutation).|P -> C (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|P -> H (in a sporadic cancer; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.P219S(4)|p.P219P(4)|p.P219L(3)|p.P219T(2)|p.D208fs*1(1)|p.V216fs*28(1)|p.Y220_P223delYEPP(1)|p.V218fs*26(1)|p.?(1)|p.P219R(1)|p.V218_P219insX(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.K164_P219del(1)|p.S215fs*27(1)|p.V218_Y220delVPY(1)|p.P219C(1)|p.V216_Y220delVVVPY(1)|p.P219H(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGGCTCATAGGGCACCACCAC	0.545		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578193	-	-	7578192	7	5	24	1	0	1	0	1	0	0	0	0	16448	987	35	0	637	0	TP53	17	7578192	Frame_Shift_Del	DEL	GG	TCGA-BB-4224-01A-01D-1434-08	321999	7578192	73617018	81	5041											
TP53	7157	broad.mit.edu	37	chr17	7578500	7578500	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtggaatcaacccacagctGcacagggcaggtcttggcca	10	7	12	12	0	2	0	1	0	1	0	2	1	2	1	2	4	3	3	2	4	2	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr17:7578500G>A	uc002gim.2	-	5	624	c.430C>T	c.(430-432)CAG>TAG	p.Q144*	TP53_uc002gig.1_Nonsense_Mutation_p.Q144*|TP53_uc002gih.2_Nonsense_Mutation_p.Q144*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q12*|TP53_uc010cng.1_Nonsense_Mutation_p.Q12*|TP53_uc002gii.1_Nonsense_Mutation_p.Q12*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q144*|TP53_uc010cni.1_Nonsense_Mutation_p.Q144*|TP53_uc002gij.2_Nonsense_Mutation_p.Q144*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.Q51*|TP53_uc002gio.2_Nonsense_Mutation_p.Q12*|TP53_uc010vug.1_Nonsense_Mutation_p.Q105*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	144	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q144*(29)|p.Q144L(8)|p.0?(7)|p.Q144H(4)|p.Q144P(4)|p.Q144R(4)|p.Q144fs*26(3)|p.Q144K(2)|p.Q144del(2)|p.Q144Q(2)|p.Q144_G154del11(1)|p.L137_W146del10(1)|p.Q144fs*32(1)|p.Q144fs*16(1)|p.P142_Q144delPVQ(1)|p.Q144fs*4(1)|p.V143_S149del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACCCACAGCTGCACAGGGCAG	0.597		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	62					0	0	0	0	A	7578500	A	A	7578500	4	1	24	1	0	0	0	0	0	1	0	0	16448	1328	46	4	868	4	TP53	17	7578500	Nonsense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	308	7578500	73616710	82	5042											
ATAD5	79915	broad.mit.edu	37	chr17	29161578	29161578	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagtagtacttctgttttacGttacaagaaacaagtagagg	15	12	9	5	1	1	2	0	0	1	2	1	2	1	2	0	1	4	5	0	1	9	7			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr17:29161578G>A	uc002hfs.1	+	2	825	c.479G>A	c.(478-480)CGT>CAT	p.R160H	ATAD5_uc002hft.1_Missense_Mutation_p.R57H	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	160					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TCTGTTTTACGTTACAAGAAA	0.313													69	199					0	0	0	0	A	29161578	A	A	29161578	3	1	24	1	0	0	0	0	1	0	0	0	1078	1145	40	1	485	1	ATAD5	17	29161578	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	21583078	29161578	52033632	83	5043											
AP2B1	163	broad.mit.edu	37	chr17	33963460	33963460	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtcatcagggacatcttccGcaaataccccaacaagtatg	13	9	7	12	1	3	0	2	0	1	0	4	1	4	1	3	1	2	2	3	1	5	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr17:33963460G>A	uc002hjr.2	+	10	1445	c.1256G>A	c.(1255-1257)CGC>CAC	p.R419H	AP2B1_uc002hjq.2_Missense_Mutation_p.R419H|AP2B1_uc010wci.1_Missense_Mutation_p.R381H|AP2B1_uc002hjs.2_Missense_Mutation_p.R362H|AP2B1_uc002hjt.2_Missense_Mutation_p.R419H|AP2B1_uc010ctv.2_Missense_Mutation_p.R419H|AP2B1_uc010wcj.1_Missense_Mutation_p.R156H	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	419					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		GACATCTTCCGCAAATACCCC	0.398													9	30					0	0	0	0	A	33963460	A	A	33963460	3	1	24	1	0	0	0	0	1	0	0	0	741	1087	38	1	1290	1	AP2B1	17	33963460	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	4801882	33963460	47231750	84	5044											
DDX52	11056	broad.mit.edu	37	chr17	36002269	36002269	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacacacctgggacagacttCttgtttccaaaaaagtccag	13	9	7	12	0	1	1	0	0	1	1	3	2	3	2	3	1	0	1	3	1	3	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr17:36002269C>G	uc002hoi.1	-	2	194	c.156G>C	c.(154-156)AAG>AAC	p.K52N	DDX52_uc002hoh.1_5'UTR|DDX52_uc002hoj.1_5'UTR	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a	52						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				GGACAGACTTCTTGTTTCCAA	0.413													29	82					0	0	0	0	G	36002269	G	G	36002269	3	3	24	1	0	0	0	0	1	0	0	0	4387	912	32	2	1699	2	DDX52	17	36002269	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	2038809	36002269	45192941	85	5045											
UNK	85451	broad.mit.edu	37	chr17	73809222	73809222	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagcccccgcggctgtgccGccaaggctatgcctgtccct	5	7	12	17	3	0	0	0	0	0	0	1	1	1	0	6	2	3	2	6	2	3	1			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr17:73809222G>A	uc002jpm.2	+	6	914	c.914G>A	c.(913-915)CGC>CAC	p.R305H		NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	229	C3H1-type 3.						nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGGCTGTGCCGCCAAGGCTAT	0.637													6	7					0	0	0	0	A	73809222	A	A	73809222	3	1	24	1	0	0	0	0	1	0	0	0	17068	1087	38	1	936	1	UNK	17	73809222	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	37806953	73809222	7385988	86	5046											
SPIRE1	56907	broad.mit.edu	37	chr18	12449740	12449740	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaatcgggcccttttgttgGccaacaccagactgcgccgg	7	9	11	14	3	1	1	1	0	0	1	2	1	1	1	4	3	2	1	4	3	2	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr18:12449740G>A	uc002kre.2	-	17	2215	c.2168C>T	c.(2167-2169)GCC>GTC	p.A723V	SPIRE1_uc002krc.2_RNA|SPIRE1_uc010wzw.1_Missense_Mutation_p.A589V|SPIRE1_uc010wzx.1_Missense_Mutation_p.A512V|SPIRE1_uc010wzy.1_Missense_Mutation_p.A709V	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a	723						cytoskeleton|perinuclear region of cytoplasm	actin binding				0						CCTTTTGTTGGCCAACACCAG	0.522													4	163					0	0	0	0	A	12449740	A	A	12449740	3	1	24	1	0	0	0	0	1	0	0	0	15137	1203	42	4	106	4	SPIRE1	18	12449740	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08		12449740	65627508	87	5047											
MAPK4	5596	broad.mit.edu	37	chr18	48190823	48190823	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagaggacctcgtgctcaaGattggggatttcgggttggc	8	10	15	8	2	1	2	1	0	0	2	3	4	1	4	1	5	1	2	1	5	1	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr18:48190823G>C	uc002lev.2	+	2	1495	c.495G>C	c.(493-495)AAG>AAC	p.K165N	MAPK4_uc010xdm.1_Intron|MAPK4_uc010doz.2_Missense_Mutation_p.K165N	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	165	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		TCGTGCTCAAGATTGGGGATT	0.562													69	30					0	0	0	0	C	48190823	C	C	48190823	3	2	24	1	0	0	0	0	1	0	0	0	9333	933	33	2	497	2	MAPK4	18	48190823	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08	35741083	48190823	29886425	88	5048											
MUC16	94025	broad.mit.edu	37	chr19	9085379	9085379	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagttatggccattggaaGagggacttcagagctgatac	13	9	13	6	0	1	4	1	1	0	3	1	6	1	6	1	3	2	2	1	3	4	4			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr19:9085379G>T	uc002mkp.2	-	1	6640	c.6436C>A	c.(6436-6438)CTT>ATT	p.L2146I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2146	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCCATTGGAAGAGGGACTTCA	0.498													30	94					1.2476e-16	1.37778e-16	1	0	T	9085379	T	T	9085379	3	4	24	1	0	0	0	0	1	0	0	0	10026	942	33	2	37423	2	MUC16	19	9085379	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08		9085379	50043604	89	5049											
C19orf57	79173	broad.mit.edu	37	chr19	14001123	14001123	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatccccactgccgggcacCgcctgcacagggctctggct	6	6	12	17	2	1	0	0	0	1	0	2	1	2	0	5	3	2	4	5	3	1	0			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr19:14001123C>T	uc002mxl.1	-	6	605	c.546G>A	c.(544-546)GCG>GCA	p.A182A	C19orf57_uc002mxk.1_Silent_p.A64A|C19orf57_uc002mxm.1_Intron	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	182					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			TGCCGGGCACCGCCTGCACAG	0.682													51	102					0	0	0	0	T	14001123	T	T	14001123	2	4	24	1	0	0	0	0	0	0	0	1	1948	639	23	1		1	C19orf57	19	14001123	Silent	SNP	C	TCGA-BB-4224-01A-01D-1434-08	4915744	14001123	45127860	90	5050											
SIRPG	55423	broad.mit.edu	37	chr20	1638344	1638344	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaccaggaggatggggccagGaggctgggacaggcattttg	9	6	19	7	0	0	0	0	0	0	0	0	5	0	4	2	8	0	2	2	8	0	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr20:1638344G>A	uc002wfm.1	-	1	82	c.17C>T	c.(16-18)TCC>TTC	p.S6F	SIRPG_uc002wfn.1_Missense_Mutation_p.S6F|SIRPG_uc002wfo.1_Missense_Mutation_p.S6F	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	6					blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						ATGGGGCCAGGAGGCTGGGAC	0.557													34	157					0	0	0	0	A	1638344	A	A	1638344	3	1	24	1	0	0	0	0	1	0	0	0	14401	1174	41	2	1166	2	SIRPG	20	1638344	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08		1638344	61387176	91	5051											
INSM1	3642	broad.mit.edu	37	chr20	20349259	20349259	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacgagaagcacaagtacttCgaacgcagcttcaacctggg	13	6	10	12	3	1	1	1	0	0	1	2	3	1	1	1	1	5	4	1	1	5	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr20:20349259C>G	uc002wrx.2	+	1	495	c.348C>G	c.(346-348)TTC>TTG	p.F116L		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	116	Ala/Gly/Pro-rich.				endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		ACAAGTACTTCGAACGCAGCT	0.597													7	10					0	0	0	0	G	20349259	G	G	20349259	3	3	24	1	0	0	0	0	1	0	0	0	7810	883	31	3	350	3	INSM1	20	20349259	Missense_Mutation	SNP	C	TCGA-BB-4224-01A-01D-1434-08	18710915	20349259	42676261	92	5052											
CACNA1I	8911	broad.mit.edu	37	chr22	39996588	39996588	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgctcaagatggtggccctgGggatttttggcaagaagtgc	8	11	15	7	0	1	2	1	0	0	2	1	3	1	3	1	5	2	2	1	5	3	2			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chr22:39996588G>T	uc003ayc.2	+	3	412	c.412G>T	c.(412-414)GGG>TGG	p.G138W	CACNA1I_uc003ayd.2_Missense_Mutation_p.G138W|CACNA1I_uc003aye.2_Missense_Mutation_p.G53W|CACNA1I_uc003ayf.2_Missense_Mutation_p.G53W	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	138	I.|Helical; Name=S2 of repeat I; (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGTGGCCCTGGGGATTTTTGG	0.562													15	15					7.93312e-07	8.3265e-07	1	0	T	39996588	T	T	39996588	3	4	24	1	0	0	0	0	1	0	0	0	2558	1232	43	4	422	4	CACNA1I	22	39996588	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08		39996588	11307978	93	5053											
PAGE2	203569	broad.mit.edu	37	chrX	55117016	55117016	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcacctagtggggagattGaaaatcaagcagtgcctgct	11	10	12	8	0	1	2	1	1	0	1	1	3	1	2	2	2	4	3	2	2	4	3			TCGA-BB-4224-01A-01D-1434-08	TCGA-BB-4224-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfa7d658-031d-4cd4-9ca3-ceaa201f702d	1531c3a5-b0ac-4076-a2b7-a9ff9b855840	g.chrX:55117016G>A	uc004duf.1	+	3	220	c.166G>A	c.(166-168)GAA>AAA	p.E56K		NM_207339	NP_997222	Q7Z2X7	GGEE2_HUMAN	P antigen family, member 2	56										ovary(2)	2						TGGGGAGATTGAAAATCAAGC	0.443													9	11					0	0	0	0	A	55117016	A	A	55117016	3	1	24	1	0	0	0	0	1	0	0	0	11444	1291	45	2	172	2	PAGE2	23	55117016	Missense_Mutation	SNP	G	TCGA-BB-4224-01A-01D-1434-08		55117016	100153544	94	5054											
ASAP3	55616	broad.mit.edu	37	chr1	23759729	23759729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gatgtccagcctcccactggCccagtgagcctgggccggga	6	6	14	15	1	0	1	0	1	0	0	2	3	2	2	6	3	2	0	6	3	0	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:23759729C>T	uc001bha.2	-	22	2288	c.2164G>A	c.(2164-2166)GCC>ACC	p.A722T	ASAP3_uc001bgy.1_Missense_Mutation_p.A226T|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Missense_Mutation_p.A612T|ASAP3_uc010oea.1_Missense_Mutation_p.A713T|ASAP3_uc001bhb.2_Missense_Mutation_p.A245T	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	722					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CTCCCACTGGCCCAGTGAGCC	0.642													39	148					0	0	0	0	T	23759729	T	T	23759729	3	4	25	1	0	0	0	0	1	0	0	0	1014	739	26	4	563	4	ASAP3	1	23759729	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08		23759729	225490892	1	5055											
ASAP3	55616	broad.mit.edu	37	chr1	23763755	23763755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccccgggccagcgctgggctCcccgaggaaggcgctgctca	5	4	15	17	4	1	0	1	0	0	0	2	2	2	1	5	4	2	4	5	4	1	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:23763755C>T	uc001bha.2	-	14	1334	c.1210G>A	c.(1210-1212)GAG>AAG	p.E404K	ASAP3_uc001bgy.1_5'Flank|ASAP3_uc001bgz.1_5'Flank|ASAP3_uc010odz.1_Missense_Mutation_p.E273K|ASAP3_uc010oea.1_Missense_Mutation_p.E395K|ASAP3_uc001bhb.2_5'UTR	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	404					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						GCGCTGGGCTCCCCGAGGAAG	0.662													5	15					0	0	0	0	T	23763755	T	T	23763755	3	4	25	1	0	0	0	0	1	0	0	0	1014	864	30	2	1549	2	ASAP3	1	23763755	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	4026	23763755	225486866	2	5056											
HECTD3	79654	broad.mit.edu	37	chr1	45475780	45475780	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgcactcgtaggtccatgTcgggggtacatagctaagca	9	9	13	10	3	0	0	0	0	0	0	4	0	1	0	1	3	3	5	1	3	4	4			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:45475780T>C	uc009vxk.2	-	4	735	c.637A>G	c.(637-639)ACA>GCA	p.T213A	HECTD3_uc001cmy.3_5'Flank|HECTD3_uc010olh.1_Intron|UROD_uc010oli.1_5'Flank|UROD_uc001cna.1_5'Flank|UROD_uc001cnb.1_5'Flank|UROD_uc010olj.1_5'Flank|UROD_uc001cnc.1_5'Flank	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	213					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					TAGGTCCATGTCGGGGGTACA	0.567													21	85					0	0	0	0	C	45475780	C	C	45475780	3	2	25	1	0	0	0	0	1	0	0	0	7080	1667	58	5	2020	5	HECTD3	1	45475780	Missense_Mutation	SNP	T	TCGA-BB-4225-01A-01D-1434-08	21712025	45475780	203774841	3	5057											
CCDC17	149483	broad.mit.edu	37	chr1	46087966	46087966	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaagatttctgcctccaagCgccggttttcagcctccact	7	11	7	16	2	2	1	1	0	1	1	4	1	4	1	6	1	3	1	6	1	2	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:46087966C>T	uc010olt.1	-	7	1062	c.914G>A	c.(913-915)CGC>CAC	p.R305H	CCDC17_uc009vxy.2_Missense_Mutation_p.R273H|CCDC17_uc010ols.1_Missense_Mutation_p.R296H|CCDC17_uc001com.3_Missense_Mutation_p.R126H|CCDC17_uc001con.3_RNA|CCDC17_uc009vxz.2_Intron	NM_001114938	NP_001108410	Q96LX7	CCD17_HUMAN	coiled-coil domain containing 17	305	Potential.									ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGCCTCCAAGCGCCGGTTTTC	0.582													10	25					0	0	0	0	T	46087966	T	T	46087966	3	4	25	1	0	0	0	0	1	0	0	0	2806	768	27	1	982	1	CCDC17	1	46087966	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	612186	46087966	203162655	4	5058											
RBM15	64783	broad.mit.edu	37	chr1	110882129	110882129	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggcggcgggttactcagctCcgcggagacgacctccgacg	6	5	16	14	7	1	1	1	0	0	1	3	4	3	1	3	4	2	2	3	4	1	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:110882129C>T	uc001dzl.1	+	1	185	c.102C>T	c.(100-102)CTC>CTT	p.L34L	RBM15_uc001dzm.1_Silent_p.L34L|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	34					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		TTACTCAGCTCCGCGGAGACG	0.677			T	MKL1	acute megakaryocytic leukemia								14	36					0	0	0	0	T	110882129	T	T	110882129	2	4	25	1	0	0	0	0	0	0	0	1	13181	842	30	2		2	RBM15	1	110882129	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	64794163	110882129	138368492	5	5059											
MAGI3	260425	broad.mit.edu	37	chr1	114092242	114092242	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagataatctctacttgaGaaccattccatgtaagtatg	14	12	7	8	0	1	2	0	1	1	2	3	4	2	2	2	0	2	2	2	0	5	6			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:114092242G>A	uc001edk.2	+	2	603	c.422G>A	c.(421-423)AGA>AAA	p.R141K	MAGI3_uc001edh.3_Missense_Mutation_p.R141K|MAGI3_uc001edi.3_Missense_Mutation_p.R141K|MAGI3_uc010owm.1_Missense_Mutation_p.R141K	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	141	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTCTACTTGAGAACCATTCCA	0.338													4	78					0	0	0	0	A	114092242	A	A	114092242	3	1	25	1	0	0	0	0	1	0	0	0	9245	942	33	2	428	2	MAGI3	1	114092242	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	3210113	114092242	135158379	6	5060											
ANKRD34A	284615	broad.mit.edu	37	chr1	145473666	145473666	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccgagatcacgcgggcgcctCggctcttgtccacgccctgg	4	7	13	17	6	2	1	1	0	1	1	4	2	3	1	4	3	0	1	4	3	0	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:145473666C>G	uc001enq.1	+	4	1631	c.338C>G	c.(337-339)TCG>TGG	p.S113W	NBPF10_uc001emp.3_Intron	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	113	ANK 4.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCGGGCGCCTCGGCTCTTGTC	0.711													15	42					0	0	0	0	G	145473666	G	G	145473666	3	3	25	1	0	0	0	0	1	0	0	0	662	893	31	3	340	3	ANKRD34A	1	145473666	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	31381424	145473666	103776955	7	5061											
CRNN	49860	broad.mit.edu	37	chr1	152382225	152382225	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactgtctcccttgagtggtCatcaacccattcctcaccaa	9	11	5	16	0	4	1	3	1	1	0	6	1	5	1	4	1	1	0	4	1	2	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:152382225C>T	uc001ezx.2	-	3	1407	c.1333G>A	c.(1333-1335)GAC>AAC	p.D445N		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	445					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGAGTGGTCATCAACCCAT	0.577													25	87					0	0	0	0	T	152382225	T	T	152382225	3	4	25	1	0	0	0	0	1	0	0	0	3907	826	29	2	158	2	CRNN	1	152382225	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	6908559	152382225	96868396	8	5062											
CD1A	909	broad.mit.edu	37	chr1	158226066	158226066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caggaaaggcacatctccagCggcaaggtcagtcctgcact	11	6	11	13	1	2	0	1	0	1	0	4	1	3	1	2	4	2	3	2	4	2	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:158226066C>T	uc001frt.2	+	3	1131	c.598C>T	c.(598-600)CGG>TGG	p.R200W		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	200	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	ACATCTCCAGCGGCAAGGTCA	0.463													8	123					0	0	0	0	T	158226066	T	T	158226066	3	4	25	1	0	0	0	0	1	0	0	0	2989	759	27	1	608	1	CD1A	1	158226066	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	5843841	158226066	91024555	9	5063											
FCRLB	127943	broad.mit.edu	37	chr1	161692465	161692465	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcagtcagatccatcatGtggccactgacagcccttct	8	10	9	14	0	3	2	2	1	1	1	4	2	4	2	3	1	2	2	3	1	0	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:161692465G>A	uc001gbh.2	+	3	237	c.3G>A	c.(1-3)ATG>ATA	p.M1I	FCRLB_uc009wus.2_Missense_Mutation_p.M1I|FCRLB_uc001gbj.2_Missense_Mutation_p.M1I|FCRLB_uc001gbk.2_Missense_Mutation_p.M1I|FCRLB_uc001gbl.2_Missense_Mutation_p.M1I|FCRLB_uc001gbm.2_Missense_Mutation_p.M1I|FCRLB_uc001gbi.2_Missense_Mutation_p.M1I	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	1						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			GATCCATCATGTGGCCACTGA	0.557													84	250					0	0	0	0	A	161692465	A	A	161692465	3	1	25	1	0	0	0	0	1	0	0	0	5833	1377	48	4	5	4	FCRLB	1	161692465	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	3466399	161692465	87558156	10	5064											
KIF21B	23046	broad.mit.edu	37	chr1	200950187	200950187	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactgcagtggggccgtccGtgcacccttggctcctccaa	6	8	11	16	2	0	0	0	0	0	0	3	0	3	0	5	3	2	3	5	3	1	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:200950187G>A	uc001gvs.1	-	29	4197	c.3880C>T	c.(3880-3882)CGG>TGG	p.R1294W	KIF21B_uc001gvr.1_Missense_Mutation_p.R1281W|KIF21B_uc009wzl.1_Missense_Mutation_p.R1294W|KIF21B_uc010ppn.1_Missense_Mutation_p.R1281W	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1294					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGGGCCGTCCGTGCACCCTTG	0.622													52	64					0	0	0	0	A	200950187	A	A	200950187	3	1	25	1	0	0	0	0	1	0	0	0	8328	1144	40	1	1061	1	KIF21B	1	200950187	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	39257722	200950187	48300434	11	5065											
GPATCH2	55105	broad.mit.edu	37	chr1	217665079	217665079	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctttcagctcgattatctCtcagaagctgatgctacaca	10	13	6	12	1	4	2	2	1	2	1	6	3	4	2	0	0	4	3	0	0	3	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:217665079C>T	uc001hlf.1	-	8	1316	c.1220G>A	c.(1219-1221)AGA>AAA	p.R407K	GPATCH2_uc009xdq.1_RNA	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	407						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		TCGATTATCTCTCAGAAGCTG	0.313													16	84					0	0	0	0	T	217665079	T	T	217665079	3	4	25	1	0	0	0	0	1	0	0	0	6629	913	32	2	378	2	GPATCH2	1	217665079	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	16714892	217665079	31585542	12	5066											
PCNXL2	80003	broad.mit.edu	37	chr1	233270852	233270852	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaagatgacagtgaagctCaagttaataaactggtaaac	20	8	8	5	0	1	3	1	2	0	1	1	3	1	3	0	1	3	3	0	1	9	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:233270852C>T	uc001hvl.2	-	21	3979	c.3744G>A	c.(3742-3744)TTG>TTA	p.L1248L	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1248	Helical; (Potential).					integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CAGTGAAGCTCAAGTTAATAA	0.398													13	50					0	0	0	0	T	233270852	T	T	233270852	2	4	25	1	0	0	0	0	0	0	0	1	11646	825	29	2		2	PCNXL2	1	233270852	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	15605773	233270852	15979769	13	5067											
RYR2	6262	broad.mit.edu	37	chr1	237895442	237895442	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttagtcggacagctttaacaGagaaatggtatggttgggag	12	11	14	4	1	0	1	0	0	0	1	1	4	0	3	0	4	2	3	0	4	4	5			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:237895442G>A	uc001hyl.1	+	78	11152	c.11032G>A	c.(11032-11034)GAG>AAG	p.E3678K	RYR2_uc010pya.1_Missense_Mutation_p.E74K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3678					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCTTTAACAGAGAAATGGTA	0.453													11	74					0	0	0	0	A	237895442	A	A	237895442	3	1	25	1	0	0	0	0	1	0	0	0	13834	943	33	2	11342	2	RYR2	1	237895442	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	4624590	237895442	11355179	14	5068											
ACOXL	55289	broad.mit.edu	37	chr2	111666365	111666365	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtctgttgattccctctaGccggaggcagtttgggccca	5	12	13	11	1	2	1	0	1	2	0	3	2	3	2	3	3	1	3	3	3	1	4	rs2974746		TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr2:111666365G>A	uc002tgr.3	+	11	1013	c.789_splice	c.e11-1	p.S263_splice	ACOXL_uc010fkc.2_Splice_Site_p.S263_splice|ACOXL_uc010yxk.1_Splice_Site_p.S263_splice	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2						fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						ATTCCCTCTAGCCGGAGGCAG	0.522													23	79					0	0	0	0	A	111666365	A	A	111666365	5	1	25	1	0	0	0	0	0	0	1	0	161	985	34	4	826	4	ACOXL	2	111666365	Splice_Site	SNP	G	TCGA-BB-4225-01A-01D-1434-08		111666365	131533008	15	5069											
HOXD3	3232	broad.mit.edu	37	chr2	177033995	177033995	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accccccaccagccctacccAccccctgctgctgccagctc	6	5	5	25	0	0	0	0	0	0	0	1	0	0	0	9	0	6	3	9	0	1	1	rs141168805	byFrequency	TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr2:177033995A>C	uc002ukt.1	+	2	329	c.153A>C	c.(151-153)CCA>CCC	p.P51P		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	51					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		AGCCCTACCCACCCCCTGCTG	0.587													8	101					0	0	0	0	C	177033995	C	C	177033995	2	2	25	1	0	0	0	0	0	0	0	1	7362	146	6	5		5	HOXD3	2	177033995	Silent	SNP	A	TCGA-BB-4225-01A-01D-1434-08	65367630	177033995	66165378	16	5070											
TTN	7273	broad.mit.edu	37	chr2	179582457	179582457	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggttctgagccattgatgcGgcattcaaatgcaactggga	11	10	12	8	1	2	2	1	2	1	0	2	3	2	3	1	3	4	3	1	3	2	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr2:179582457G>A	uc010zfg.1	-	84	21636	c.21412C>T	c.(21412-21414)CGC>TGC	p.R7138C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R3799C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8065							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATTGATGCGGCATTCAAAT	0.413													6	46					0	0	0	0	A	179582457	A	A	179582457	3	1	25	1	0	0	0	0	1	0	0	0	16803	1116	39	1	79489	1	TTN	2	179582457	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	2548462	179582457	63616916	17	5071											
ATG16L1	55054	broad.mit.edu	37	chr2	234171780	234171780	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtttgccaatttagtcccGgacatgatggcacatggaat	10	12	11	8	1	0	1	0	1	0	0	1	3	1	3	2	4	1	2	2	4	3	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr2:234171780G>A	uc002vty.2	+	3	471	c.214G>A	c.(214-216)GGA>AGA	p.G72R	ATG16L1_uc002vtx.1_Intron|ATG16L1_uc002vua.2_Missense_Mutation_p.G72R|ATG16L1_uc002vub.2_5'UTR|ATG16L1_uc002vtz.2_Intron|ATG16L1_uc002vud.3_5'UTR	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	72					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		ATTTAGTCCCGGACATGATGG	0.438													7	31					0	0	0	0	A	234171780	A	A	234171780	3	1	25	1	0	0	0	0	1	0	0	0	1093	1117	39	1	224	1	ATG16L1	2	234171780	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	54589323	234171780	9027593	18	5072											
SCN5A	6331	broad.mit.edu	37	chr3	38647495	38647495	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctggaagcgcttttccttctCctcggtctcagcgatggtgg	4	13	12	12	3	2	0	1	0	2	0	6	2	3	1	2	4	2	1	2	4	1	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr3:38647495C>T	uc003cio.2	-	10	1479	c.1285G>A	c.(1285-1287)GAG>AAG	p.E429K	SCN5A_uc003cin.2_Missense_Mutation_p.E429K|SCN5A_uc003cil.3_Missense_Mutation_p.E429K|SCN5A_uc010hhi.2_Missense_Mutation_p.E429K|SCN5A_uc010hhk.2_Missense_Mutation_p.E429K|SCN5A_uc011ayr.1_Missense_Mutation_p.E429K|SCN5A_uc010hhj.1_Missense_Mutation_p.E40K	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	429					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TTTTCCTTCTCCTCGGTCTCA	0.567													4	143					0	0	0	0	T	38647495	T	T	38647495	3	4	25	1	0	0	0	0	1	0	0	0	13987	864	30	2	4841	2	SCN5A	3	38647495	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08		38647495	159374935	19	5073											
RHO	6010	broad.mit.edu	37	chr3	129251103	129251103	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtcctcaggtacatcccCgagggcctgcagtgctcgtg	5	9	12	15	2	1	0	1	0	0	0	4	1	3	0	5	2	3	3	5	2	1	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr3:129251103C>T	uc003emt.2	+	3	635	c.540C>T	c.(538-540)CCC>CCT	p.P180P		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	180	Extracellular.				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	GGTACATCCCCGAGGGCCTGC	0.587													14	90					0	0	0	0	T	129251103	T	T	129251103	2	4	25	1	0	0	0	0	0	0	0	1	13395	639	23	1		1	RHO	3	129251103	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	90603608	129251103	68771327	20	5074											
GHSR	2693	broad.mit.edu	37	chr3	172165615	172165615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaactcggtggggcggcactCgttggtgtcccaagggtcgg	6	8	17	10	4	0	0	0	0	0	0	4	0	1	0	1	7	1	2	1	7	2	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr3:172165615C>T	uc003fib.1	-	1	589	c.589G>A	c.(589-591)GAG>AAG	p.E197K	GHSR_uc011bpv.1_Missense_Mutation_p.E197K	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	197	Extracellular (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GGGCGGCACTCGTTGGTGTCC	0.622													17	76					0	0	0	0	T	172165615	T	T	172165615	3	4	25	1	0	0	0	0	1	0	0	0	6412	893	31	1	593	1	GHSR	3	172165615	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	42914512	172165615	25856815	21	5075											
WDR53	348793	broad.mit.edu	37	chr3	196288329	196288329	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggagaagaatgcccaccCgtccacttgactgccataat	13	7	8	13	1	0	3	0	1	0	2	1	4	1	3	4	1	2	0	4	1	3	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr3:196288329C>T	uc003fwt.2	-	3	489	c.18G>A	c.(16-18)ACG>ACA	p.T6T		NM_182627	NP_872433	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	6										breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		AATGCCCACCCGTCCACTTGA	0.522													15	89					0	0	0	0	T	196288329	T	T	196288329	2	4	25	1	0	0	0	0	0	0	0	1	17373	639	23	1		1	WDR53	3	196288329	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	24122714	196288329	1734101	22	5076											
BMP2K	55589	broad.mit.edu	37	chr4	79792071	79792071	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcaactccatttacagcatCgtcatcctcaccagcagcag	12	8	6	15	1	2	0	2	0	0	0	5	0	4	0	3	0	6	4	3	0	2	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr4:79792071C>T	uc003hlk.2	+	11	1532	c.1366C>T	c.(1366-1368)CGT>TGT	p.R456C	BMP2K_uc010ijl.1_RNA|BMP2K_uc003hlj.2_Missense_Mutation_p.R456C|BMP2K_uc003hll.2_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	456	Gln/His-rich.					nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						TTTACAGCATCGTCATCCTCA	0.294													4	35					0	0	0	0	T	79792071	T	T	79792071	3	4	25	1	0	0	0	0	1	0	0	0	1463	884	31	1	1408	1	BMP2K	4	79792071	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08		79792071	111362205	23	5077											
FRG1	2483	broad.mit.edu	37	chr4	190878594	190878594	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaatagctgctttattagAtgcaatgaagcaggggacat	14	11	10	6	0	1	2	1	1	0	1	1	3	1	3	0	2	4	4	0	2	6	4			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr4:190878594A>T	uc003izs.2	+	6	665	c.474A>T	c.(472-474)AGA>AGT	p.R158S		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	158					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		GCTTTATTAGATGCAATGAAG	0.368													4	46					0	0	0	0	T	190878594	T	T	190878594	3	4	25	1	0	0	0	0	1	0	0	0	6080	330	12	5	496	5	FRG1	4	190878594	Missense_Mutation	SNP	A	TCGA-BB-4225-01A-01D-1434-08	111086523	190878594	275682	24	5078											
HEATR7B2	133558	broad.mit.edu	37	chr5	41008798	41008798	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcatcttctggcccagtGtgcagctaaccagcttcagg	8	10	11	12	0	3	1	1	1	2	0	3	1	3	1	2	2	5	4	2	2	1	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:41008798G>A	uc003jmj.3	-	33	4008	c.3518C>T	c.(3517-3519)ACA>ATA	p.T1173I	HEATR7B2_uc003jmi.3_Missense_Mutation_p.T728I	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1173	HEAT 13.						binding			ovary(6)|central_nervous_system(2)	8						CTGGCCCAGTGTGCAGCTAAC	0.567													25	55					0	0	0	0	A	41008798	A	A	41008798	3	1	25	1	0	0	0	0	1	0	0	0	7074	1377	48	4	1279	4	HEATR7B2	5	41008798	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08		41008798	139906462	25	5079											
PRR16	51334	broad.mit.edu	37	chr5	120021719	120021719	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgactgacagctccaaaaCggacacgctgaatagtagct	14	7	10	10	2	0	3	0	3	0	0	1	5	1	4	1	1	3	4	1	1	5	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:120021719C>T	uc003ksq.2	+	2	393	c.230C>T	c.(229-231)ACG>ATG	p.T77M	PRR16_uc003ksp.2_Missense_Mutation_p.T54M|PRR16_uc003ksr.2_Missense_Mutation_p.T7M	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	77										pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		AGCTCCAAAACGGACACGCTG	0.502													30	85					0	0	0	0	T	120021719	T	T	120021719	3	4	25	1	0	0	0	0	1	0	0	0	12651	536	19	1	167	1	PRR16	5	120021719	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	79012921	120021719	60893541	26	5080											
PCDHA11	56138	broad.mit.edu	37	chr5	140248820	140248820	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggccaaacacggcaccttCgtgggccgcatcgcgcagga	9	4	14	14	5	0	0	0	0	0	0	2	2	0	1	3	4	1	3	3	4	1	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:140248820C>T	uc003lia.2	+	1	990	c.132C>T	c.(130-132)TTC>TTT	p.F44F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.F44F	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	44	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGCACCTTCGTGGGCCGCA	0.652													47	138					0	0	0	0	T	140248820	T	T	140248820	2	4	25	1	0	0	0	0	0	0	0	1	11575	883	31	1		1	PCDHA11	5	140248820	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	20227101	140248820	40666440	27	5081											
PCDHAC2	56134	broad.mit.edu	37	chr5	140347507	140347507	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacccaacaccattgtggccGttctcagtgtcaatgaccaa	11	9	7	14	1	2	1	2	1	1	0	3	1	2	1	4	1	1	1	4	1	3	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:140347507G>A	uc003lii.2	+	1	1396	c.1156G>A	c.(1156-1158)GTT>ATT	p.V386I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.V386I	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	386	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTGTGGCCGTTCTCAGTGT	0.557													4	139					0	0	0	0	A	140347507	A	A	140347507	3	1	25	1	0	0	0	0	1	0	0	0	11587	1145	40	1	1158	1	PCDHAC2	5	140347507	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	98687	140347507	40567753	28	5082											
PCDHB13	56123	broad.mit.edu	37	chr5	140595079	140595079	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctacaccctgttcgtccgcGagaacaacagccccgccctg	8	6	8	19	4	0	1	0	0	0	1	2	2	1	1	6	0	4	1	6	0	3	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:140595079G>A	uc003lja.1	+	1	1571	c.1384G>A	c.(1384-1386)GAG>AAG	p.E462K		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	462	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCGTCCGCGAGAACAACAG	0.602													27	186					0	0	0	0	A	140595079	A	A	140595079	3	1	25	1	0	0	0	0	1	0	0	0	11592	1059	37	1	1386	1	PCDHB13	5	140595079	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	247572	140595079	40320181	29	5083											
PCDHGB1	56104	broad.mit.edu	37	chr5	140731948	140731948	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgcggtgattctagcgatCgccctgcgcctgcgacgttc	4	10	12	15	7	1	1	0	1	1	0	4	3	1	1	2	1	3	1	2	1	1	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:140731948C>T	uc003ljo.1	+	1	2121	c.2121C>T	c.(2119-2121)ATC>ATT	p.I707I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA4_uc003ljq.1_5'Flank|PCDHGB1_uc011daq.1_Silent_p.I707I|PCDHGA4_uc003ljp.1_5'Flank	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	707	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTAGCGATCGCCCTGCGCC	0.617													61	214					0	0	0	0	T	140731948	T	T	140731948	2	4	25	1	0	0	0	0	0	0	0	1	11616	874	31	1		1	PCDHGB1	5	140731948	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	136869	140731948	40183312	30	5084											
BTNL2	56244	broad.mit.edu	37	chr6	32372831	32372831	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttcagtgccacatttccCtttgcaatgccattctctat	8	16	4	13	0	3	0	1	0	2	0	5	0	4	0	3	0	3	1	3	0	2	5			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr6:32372831C>G	uc003obg.1	-	2	312	c.312G>C	c.(310-312)AAG>AAC	p.K104N	BTNL2_uc010jty.1_Intron|BTNL2_uc010jtz.1_Intron|BTNL2_uc010jua.1_Intron	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	104	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						CCACATTTCCCTTTGCAATGC	0.507													55	95					0	0	0	0	G	32372831	G	G	32372831	3	3	25	1	0	0	0	0	1	0	0	0	1570	680	24	4	1075	4	BTNL2	6	32372831	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08		32372831	138742236	31	5085											
FUCA2	2519	broad.mit.edu	37	chr6	143825112	143825112	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattgatccggtgctcctccGtcaccatccgaccacagaac	9	9	7	16	3	1	2	1	1	0	1	5	3	5	2	6	1	2	1	6	1	2	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr6:143825112G>A	uc003qjm.2	-	3	782	c.690C>T	c.(688-690)GAC>GAT	p.D230D	FUCA2_uc003qjn.2_5'Flank	NM_032020	NP_114409	Q9BTY2	FUCO2_HUMAN	fucosidase, alpha-L- 2, plasma precursor	230					fucose metabolic process	extracellular region	alpha-L-fucosidase activity|cation binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;7.45e-06)|GBM - Glioblastoma multiforme(68;0.0142)		GTGCTCCTCCGTCACCATCCG	0.463													15	35					0	0	0	0	A	143825112	A	A	143825112	2	1	25	1	0	0	0	0	0	0	0	1	6129	1136	40	1		1	FUCA2	6	143825112	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08	111452281	143825112	27289955	32	5086											
UTRN	7402	broad.mit.edu	37	chr6	145069596	145069596	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgtgcggaatggctggaaGcccgtgggagacttactcat	8	9	14	10	3	1	1	1	0	0	1	2	4	2	3	2	4	3	1	2	4	3	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr6:145069596G>A	uc003qkt.2	+	54	8246	c.8154G>A	c.(8152-8154)AAG>AAA	p.K2718K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2718	Spectrin 20.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATGGCTGGAAGCCCGTGGGAG	0.473													3	60					0	0	0	0	A	145069596	A	A	145069596	2	1	25	1	0	0	0	0	0	0	0	1	17171	962	34	4		4	UTRN	6	145069596	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08	1244484	145069596	26045471	33	5087											
THBS2	7058	broad.mit.edu	37	chr6	169648954	169648954	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtagtcaaagcgcacgaagCggtaagccggcacgccgggg	10	4	16	11	6	1	0	1	0	0	0	1	1	1	0	2	4	3	4	2	4	4	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr6:169648954C>T	uc003qwt.2	-	4	415	c.167G>A	c.(166-168)CGC>CAC	p.R56H		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	56	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GCGCACGAAGCGGTAAGCCGG	0.587													14	31					0	0	0	0	T	169648954	T	T	169648954	3	4	25	1	0	0	0	0	1	0	0	0	15920	768	27	1	3431	1	THBS2	6	169648954	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	24579358	169648954	1466113	34	5088											
FBXL18	80028	broad.mit.edu	37	chr7	5521496	5521496	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggggacgtcccggatgacGtcggtcaggccctcgtggag	6	6	18	11	5	1	1	1	1	0	0	4	4	2	4	2	6	0	0	2	6	0	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr7:5521496G>A	uc003son.3	-	5	2161	c.2067C>T	c.(2065-2067)GAC>GAT	p.D689D		NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	Error:Variant_position_missing_in_Q96ME1_after_alignment										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		CCCGGATGACGTCGGTCAGGC	0.617													64	161					0	0	0	0	A	5521496	A	A	5521496	2	1	25	1	0	0	0	0	0	0	0	1	5746	1136	40	1		1	FBXL18	7	5521496	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08		5521496	153617167	35	5089											
CROT	54677	broad.mit.edu	37	chr7	87027901	87027901	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgatgcggaaaagctagttCagctgactttttgtgctttt	8	16	10	7	1	1	2	1	2	0	0	1	3	1	3	0	1	4	4	0	1	3	6			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr7:87027901C>T	uc003uit.2	+	18	2025	c.1780C>T	c.(1780-1782)CAG>TAG	p.Q594*	CROT_uc003uiu.2_Nonsense_Mutation_p.Q622*	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	594					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	AAAGCTAGTTCAGCTGACTTT	0.373													20	70					0	0	0	0	T	87027901	T	T	87027901	4	4	25	1	0	0	0	0	0	1	0	0	3909	827	29	2	1930	2	CROT	7	87027901	Nonsense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	81506405	87027901	72110762	36	5090											
ARF5	381	broad.mit.edu	37	chr7	127231136	127231136	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gggctacagcacttacgcagCcgcacggtaggggtcctgcc	7	6	14	14	3	0	0	0	0	0	0	1	0	1	0	3	4	5	5	3	4	3	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr7:127231136C>T	uc003vmb.1	+	5	486	c.450C>T	c.(448-450)AGC>AGT	p.S150S	FSCN3_uc003vmc.1_5'Flank|FSCN3_uc011kog.1_5'Flank|FSCN3_uc011koh.1_5'Flank|FSCN3_uc003vmd.1_5'Flank|FSCN3_uc010llc.1_5'Flank	NM_001662	NP_001653	P84085	ARF5_HUMAN	ADP-ribosylation factor 5	150					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1						ACTTACGCAGCCGCACGGTAG	0.577													13	192					0	0	0	0	T	127231136	T	T	127231136	2	4	25	1	0	0	0	0	0	0	0	1	847	738	26	4		4	ARF5	7	127231136	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	40203235	127231136	31907527	37	5091											
DOCK5	80005	broad.mit.edu	37	chr8	25159858	25159858	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taggaccttagcagcatggaCctcatccggccccgcgtcag	8	7	11	15	3	2	0	2	0	0	0	3	2	3	2	5	3	2	2	5	3	2	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:25159858C>T	uc003xeg.2	+	10	1001	c.864C>T	c.(862-864)GAC>GAT	p.D288D	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Silent_p.D2D|DOCK5_uc003xef.2_Silent_p.D288D	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	288						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GCAGCATGGACCTCATCCGGC	0.557													24	27					0	0	0	0	T	25159858	T	T	25159858	2	4	25	1	0	0	0	0	0	0	0	1	4712	506	18	4		4	DOCK5	8	25159858	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08		25159858	121204164	38	5092											
EPHX2	2053	broad.mit.edu	37	chr8	27398085	27398085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgcaggaggactttttgtaAatagcccagaagagcccagc	12	9	11	9	0	0	2	0	0	0	2	0	4	0	4	2	2	4	2	2	2	4	5			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:27398085A>G	uc003xfu.2	+	15	1372	c.1291A>G	c.(1291-1293)AAT>GAT	p.N431D	EPHX2_uc010luu.2_Missense_Mutation_p.N399D|EPHX2_uc010luv.2_Missense_Mutation_p.N365D|EPHX2_uc003xfv.2_Missense_Mutation_p.N378D|EPHX2_uc010luw.2_Missense_Mutation_p.N365D	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	431	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	ACTTTTTGTAAATAGCCCAGA	0.502													43	91					0	0	0	0	G	27398085	G	G	27398085	3	3	25	1	0	0	0	0	1	0	0	0	5204	14	1	5	1349	5	EPHX2	8	27398085	Missense_Mutation	SNP	A	TCGA-BB-4225-01A-01D-1434-08	2238227	27398085	118965937	39	5093											
PAG1	55824	broad.mit.edu	37	chr8	81897445	81897445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtccccgtccacacttctcgCcgtgagcatggtatccactg	6	10	9	16	3	1	1	0	1	1	0	5	1	4	1	5	1	1	2	5	1	1	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:81897445C>T	uc003ybz.2	-	7	1153	c.442G>A	c.(442-444)GCG>ACG	p.A148T		NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid	148	Cytoplasmic (Potential).				epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			ACACTTCTCGCCGTGAGCATG	0.577													14	129					0	0	0	0	T	81897445	T	T	81897445	3	4	25	1	0	0	0	0	1	0	0	0	11442	739	26	4	868	4	PAG1	8	81897445	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	54499360	81897445	64466577	40	5094											
FBXO43	286151	broad.mit.edu	37	chr8	101153320	101153320	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgactgcgagctttgttcccGaagggtggacagtcttctcg	6	12	13	10	3	2	1	0	1	2	0	4	4	3	2	1	2	2	2	1	2	1	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:101153320G>A	uc003yjd.2	-	2	1875	c.1162C>T	c.(1162-1164)CGG>TGG	p.R388W	FBXO43_uc003yje.2_Missense_Mutation_p.R354W|FBXO43_uc010mbp.1_Missense_Mutation_p.R388W	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	388					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			CTTTGTTCCCGAAGGGTGGAC	0.483													61	281					0	0	0	0	A	101153320	A	A	101153320	3	1	25	1	0	0	0	0	1	0	0	0	5784	1057	37	1	980	1	FBXO43	8	101153320	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	19255875	101153320	45210702	41	5095											
CYP11B1	1584	broad.mit.edu	37	chr8	143961145	143961145	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgtcctggggacccgggCggctctcgtgcccagtgcct	3	8	14	16	3	1	0	0	0	1	0	3	1	2	1	4	4	2	1	4	4	0	0	rs144224988	byFrequency	TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:143961145C>T	uc003yxi.2	-	1	92	c.85G>A	c.(85-87)GCC>ACC	p.A29T	CYP11B1_uc003yxj.2_Missense_Mutation_p.A29T|CYP11B1_uc010mey.2_Missense_Mutation_p.A29T	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	29					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GGGACCCGGGCGGCTCTCGTG	0.642									Familial_Hyperaldosteronism_type_I				42	218					0	0	0	0	T	143961145	T	T	143961145	3	4	25	1	0	0	0	0	1	0	0	0	4162	768	27	1	1462	1	CYP11B1	8	143961145	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	42807825	143961145	2402877	42	5096											
ZNF623	9831	broad.mit.edu	37	chr8	144733541	144733541	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagagattttaactcaactaCaaacgttaaaaataatcaaa	21	10	4	6	1	2	1	2	0	0	1	2	3	2	1	0	0	4	1	0	0	9	5			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:144733541C>A	uc003yzd.2	+	1	1588	c.1499C>A	c.(1498-1500)ACA>AAA	p.T500K	ZNF623_uc011lkp.1_Missense_Mutation_p.T460K|ZNF623_uc003yzc.2_Missense_Mutation_p.T460K	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	500					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AACTCAACTACAAACGTTAAA	0.413													8	287					0.00307968	0.00334517	1	0	A	144733541	A	A	144733541	3	1	25	1	0	0	0	0	1	0	0	0	18114	478	17	4	1501	4	ZNF623	8	144733541	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	772396	144733541	1630481	43	5097											
SVEP1	79987	broad.mit.edu	37	chr9	113168736	113168736	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagagctccactggccatcGgcttcacaggtgatttcaga	9	9	10	13	1	2	3	2	1	0	2	4	3	3	3	3	3	1	2	3	3	0	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr9:113168736G>A	uc010mtz.2	-	38	9481	c.9144C>T	c.(9142-9144)GCC>GCT	p.A3048A	SVEP1_uc010mty.2_Silent_p.A974A	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3048	Sushi 27.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ACTGGCCATCGGCTTCACAGG	0.498													49	31					0	0	0	0	A	113168736	A	A	113168736	2	1	25	1	0	0	0	0	0	0	0	1	15486	1103	39	1		1	SVEP1	9	113168736	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08		113168736	28044695	44	5098											
GLT6D1	360203	broad.mit.edu	37	chr9	138516492	138516492	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttatttgcggagtgtaggaaCggcctcaggtactcctctgc	7	12	12	10	2	2	0	1	0	1	0	3	2	3	2	2	4	4	2	2	4	4	4			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr9:138516492C>T	uc010nbd.1	-	5	536	c.282G>A	c.(280-282)CCG>CCA	p.P94P		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	94	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		AGTGTAGGAACGGCCTCAGGT	0.393													22	84					0	0	0	0	T	138516492	T	T	138516492	2	4	25	1	0	0	0	0	0	0	0	1	6505	523	19	1		1	GLT6D1	9	138516492	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	25347756	138516492	2696939	45	5099											
NOTCH1	4851	broad.mit.edu	37	chr9	139412263	139412263	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggtggcgtcgttctggCacgggttcgagacgcactcg	5	8	17	11	6	1	1	0	0	1	1	4	2	1	1	0	5	0	5	0	5	0	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr9:139412263C>T	uc004chz.2	-	8	1382	c.1382G>A	c.(1381-1383)TGC>TAC	p.C461Y		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	461	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTCGTTCTGGCACGGGTTCGA	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			52	27					0	0	0	0	T	139412263	T	T	139412263	3	4	25	1	0	0	0	0	1	0	0	0	10601	710	25	4	6393	4	NOTCH1	9	139412263	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	895771	139412263	1801168	46	5100											
OIT3	170392	broad.mit.edu	37	chr10	74673159	74673159	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgaccaacacctcctgccGaggagtgtccaacggcaccc	9	5	9	18	2	0	1	0	1	0	0	2	3	2	2	7	2	3	1	7	2	2	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr10:74673159G>A	uc001jte.1	+	6	1102	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	295	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					ACCTCCTGCCGAGGAGTGTCC	0.542													62	149					0	0	0	0	A	74673159	A	A	74673159	3	1	25	1	0	0	0	0	1	0	0	0	10903	1058	37	1	906	1	OIT3	10	74673159	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08		74673159	60861588	47	5101											
AFAP1L2	84632	broad.mit.edu	37	chr10	116057015	116057015	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaggtgggtggtgtccacGgtggtgcctaacgtcacagg	6	9	16	10	2	1	0	1	0	0	0	3	0	3	0	3	6	2	0	3	6	1	1	rs150853765	byFrequency	TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr10:116057015G>A	uc001lbn.2	-	17	2572	c.2271C>T	c.(2269-2271)ACC>ACT	p.T757T	AFAP1L2_uc001lbo.2_Silent_p.T757T|AFAP1L2_uc010qse.1_Silent_p.T810T|AFAP1L2_uc001lbp.2_Silent_p.T785T|AFAP1L2_uc001lbm.2_Silent_p.T196T|AFAP1L2_uc010qsd.1_Silent_p.T323T|AFAP1L2_uc001lbq.1_Silent_p.T279T	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	757					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		TGGTGTCCACGGTGGTGCCTA	0.652													18	52					0	0	0	0	A	116057015	A	A	116057015	2	1	25	1	0	0	0	0	0	0	0	1	355	1103	39	1		1	AFAP1L2	10	116057015	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08	41383856	116057015	19477732	48	5102											
ABCC8	6833	broad.mit.edu	37	chr11	17426127	17426127	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggggcaagagggccacgagGaacacaggtgtgacatagga	14	3	17	7	1	0	2	0	1	0	1	0	5	0	4	1	6	1	1	1	6	3	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:17426127G>A	uc001mnc.2	-	28	3615	c.3489C>T	c.(3487-3489)TTC>TTT	p.F1163F		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1163	Helical; Name=15; (By similarity).|ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GGGCCACGAGGAACACAGGTG	0.627													17	96					0	0	0	0	A	17426127	A	A	17426127	2	1	25	1	0	0	0	0	0	0	0	1	58	1165	41	2		2	ABCC8	11	17426127	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08		17426127	117580389	49	5103											
ASRGL1	80150	broad.mit.edu	37	chr11	62159699	62159699	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgggcagccgccaaggaCggcaagctgcacttcggaat	9	5	13	14	3	0	0	0	0	0	0	1	2	0	2	3	4	3	4	3	4	3	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:62159699C>T	uc001nte.3	+	7	1154	c.870C>T	c.(868-870)GAC>GAT	p.D290D	ASRGL1_uc001ntf.3_Silent_p.D290D|ASRGL1_uc001ntg.3_Silent_p.D162D	NM_025080	NP_079356	Q7L266	ASGL1_HUMAN	asparaginase-like 1	290					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	CCGCCAAGGACGGCAAGCTGC	0.532											OREG0021023	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	79	84					0	0	0	0	T	62159699	T	T	62159699	2	4	25	1	0	0	0	0	0	0	0	1	1062	535	19	1		1	ASRGL1	11	62159699	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	44733572	62159699	72846817	50	5104											
PLCB3	5331	broad.mit.edu	37	chr11	64033385	64033385	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgctgatgtggaggacacGaaggagggggaggacgaggc	10	3	21	7	3	0	1	0	1	0	0	0	8	0	6	1	7	0	1	1	7	1	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:64033385G>A	uc001nzb.2	+	26	3063	c.3063G>A	c.(3061-3063)ACG>ACA	p.T1021T	PLCB3_uc009ypg.1_Silent_p.T1021T|PLCB3_uc009yph.1_Silent_p.T954T|PLCB3_uc009ypi.2_Silent_p.T1021T	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1021					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						TGGAGGACACGAAGGAGGGGG	0.662													21	29					0	0	0	0	A	64033385	A	A	64033385	2	1	25	1	0	0	0	0	0	0	0	1	12084	1045	37	1		1	PLCB3	11	64033385	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08	1873686	64033385	70973131	51	5105											
CTTN	2017	broad.mit.edu	37	chr11	70260656	70260656	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accctgttccagtcagctgtCggccacgaatatcagtcgaa	10	9	9	13	3	2	0	2	0	0	0	5	2	3	0	3	1	1	2	3	1	3	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:70260656C>T	uc001opv.3	+	6	506	c.300C>T	c.(298-300)GTC>GTT	p.V100V	CTTN_uc001opu.2_Silent_p.V100V|CTTN_uc001opw.3_Silent_p.V100V	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	100	Cortactin 1.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		AGTCAGCTGTCGGCCACGAAT	0.557													17	89					0	0	0	0	T	70260656	T	T	70260656	2	4	25	1	0	0	0	0	0	0	0	1	4061	871	31	1		1	CTTN	11	70260656	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	6227271	70260656	64745860	52	5106											
PDE2A	5138	broad.mit.edu	37	chr11	72292993	72292993	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcatgctcaggatggccTggagagggcagagggaggta	10	5	19	7	0	1	2	1	0	0	2	1	5	1	4	1	6	2	5	1	6	1	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:72292993T>C	uc010rrc.1	-	22	2095	c.1852_splice	c.e22-1	p.A618_splice	PDE2A_uc001oso.2_Splice_Site_p.A597_splice|PDE2A_uc010rra.1_Splice_Site_p.A611_splice|PDE2A_uc001osn.2_Splice_Site_p.A362_splice|PDE2A_uc010rrb.1_Splice_Site_p.A609_splice|PDE2A_uc010rrd.1_Splice_Site_p.A503_splice	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1						platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CAGGATGGCCTGGAGAGGGCA	0.567													3	65					0	0	0	0	C	72292993	C	C	72292993	5	2	25	1	0	0	0	0	0	0	1	0	11690	1594	55	5	1015	5	PDE2A	11	72292993	Splice_Site	SNP	T	TCGA-BB-4225-01A-01D-1434-08	2032337	72292993	62713523	53	5107											
DLAT	1737	broad.mit.edu	37	chr11	111916646	111916646	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcattattacctttctatCgatgtaaatatgggagaagt	12	15	7	7	1	2	1	1	0	1	1	3	3	2	1	2	1	1	1	2	1	7	6			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:111916646C>T	uc001pmo.2	+	10	2009	c.1350C>T	c.(1348-1350)ATC>ATT	p.I450I	DLAT_uc009yyk.1_Silent_p.I345I|DLAT_uc010rwr.1_Silent_p.I323I	NM_001931	NP_001922	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase precursor	450	Catalytic (By similarity).				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding				0		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	ACCTTTCTATCGATGTAAATA	0.299													10	54					0	0	0	0	T	111916646	T	T	111916646	2	4	25	1	0	0	0	0	0	0	0	1	4571	874	31	1		1	DLAT	11	111916646	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	39623653	111916646	23089870	54	5108											
IFFO1	25900	broad.mit.edu	37	chr12	6665033	6665033	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcggggccgggcccggccCgggcggcgagtaggcagcag	5	1	22	13	6	0	0	0	0	0	0	0	1	0	0	3	8	1	3	3	8	1	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr12:6665033C>T	uc001qpd.1	-	1	197	c.163G>A	c.(163-165)GGG>AGG	p.G55R	IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_Missense_Mutation_p.G55R|IFFO1_uc001qpf.1_Missense_Mutation_p.G55R|IFFO1_uc001qpc.1_Missense_Mutation_p.G55R	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	55						intermediate filament					0						gggcccggcccgggcggcgAG	0.587													4	64					0	0	0	0	T	6665033	T	T	6665033	3	4	25	1	0	0	0	0	1	0	0	0	7549	652	23	1	1568	1	IFFO1	12	6665033	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08		6665033	127186862	55	5109											
LRP6	4040	broad.mit.edu	37	chr12	12315147	12315147	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccttcggcagggtccaacgcGagagctctgggactatctag	8	8	13	12	3	2	1	0	0	2	1	4	3	3	2	2	3	2	2	2	3	3	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr12:12315147G>A	uc001rah.3	-	10	2401	c.2259C>T	c.(2257-2259)CTC>CTT	p.L753L	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Silent_p.L753L	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	753	Extracellular (Potential).|Beta-propeller 3.|LDL-receptor class B 12.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				GGTCCAACGCGAGAGCTCTGG	0.478													13	199					0	0	0	0	A	12315147	A	A	12315147	2	1	25	1	0	0	0	0	0	0	0	1	9012	1045	37	1		1	LRP6	12	12315147	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08	5650114	12315147	121536748	56	5110											
SLC6A15	55117	broad.mit.edu	37	chr12	85266897	85266897	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttctcatttatgacatttgCtttgaagcccagaactgcaa	11	15	6	9	0	1	3	1	2	1	1	2	3	1	3	1	0	4	2	1	0	4	5			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr12:85266897C>T	uc001szv.2	-	7	1571	c.1078G>A	c.(1078-1080)GCA>ACA	p.A360T	SLC6A15_uc010sul.1_Missense_Mutation_p.A253T|SLC6A15_uc001szw.1_Missense_Mutation_p.A68T	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	360	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						ATGACATTTGCTTTGAAGCCC	0.333													13	72					0	0	0	0	T	85266897	T	T	85266897	3	4	25	1	0	0	0	0	1	0	0	0	14742	797	28	4	1138	4	SLC6A15	12	85266897	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	72951750	85266897	48584998	57	5111											
ANO4	121601	broad.mit.edu	37	chr12	101480443	101480443	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtcttcctgccagatctgCgtggtgattgctgccgtgtt	3	16	12	10	2	2	2	0	1	2	1	3	2	3	2	3	1	4	2	3	1	0	4			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr12:101480443C>T	uc010svm.1	+	17	2114	c.1542C>T	c.(1540-1542)TGC>TGT	p.C514C	ANO4_uc001thw.2_Silent_p.C479C|ANO4_uc001thx.2_Silent_p.C514C|ANO4_uc001thy.2_Silent_p.C34C	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	514	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GCCAGATCTGCGTGGTGATTG	0.507										HNSCC(74;0.22)			9	672					0	0	0	0	T	101480443	T	T	101480443	2	4	25	1	0	0	0	0	0	0	0	1	699	776	27	1		1	ANO4	12	101480443	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	16213546	101480443	32371452	58	5112											
TXNRD1	7296	broad.mit.edu	37	chr12	104719127	104719127	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttacaggttgaacaaattGaagcagggacaccaggccga	14	7	11	9	1	1	2	0	2	1	0	1	4	1	3	2	3	3	2	2	3	4	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr12:104719127G>A	uc010swk.1	+	11	1250	c.1228G>A	c.(1228-1230)GAA>AAA	p.E410K	TXNRD1_uc010swl.1_Missense_Mutation_p.E260K|TXNRD1_uc010swm.1_Missense_Mutation_p.E312K|TXNRD1_uc010swn.1_Missense_Mutation_p.E260K|TXNRD1_uc010swo.1_Missense_Mutation_p.E260K|TXNRD1_uc010swp.1_Missense_Mutation_p.E222K|TXNRD1_uc010swq.1_Missense_Mutation_p.E310K|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.E326K	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	410					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						TGAACAAATTGAAGCAGGGAC	0.418													5	23					0	0	0	0	A	104719127	A	A	104719127	3	1	25	1	0	0	0	0	1	0	0	0	16875	1291	45	2	1284	2	TXNRD1	12	104719127	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	3238684	104719127	29132768	59	5113											
TBPL2	387332	broad.mit.edu	37	chr14	55903726	55903726	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acaggggagacctgggtgggGcaaggccatcctaggcagtt	9	6	17	9	0	0	1	0	0	0	1	1	2	1	1	3	7	0	3	3	7	2	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr14:55903726G>A	uc001xby.2	-	2	161	c.161C>T	c.(160-162)GCC>GTC	p.A54V		NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	54					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						CCTGGGTGGGGCAAGGCCATC	0.483													4	202					0	0	0	0	A	55903726	A	A	55903726	3	1	25	1	0	0	0	0	1	0	0	0	15712	1203	42	4	990	4	TBPL2	14	55903726	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08		55903726	51445814	60	5114											
MTMR10	54893	broad.mit.edu	37	chr15	31234209	31234209	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttctccttggaagtaattCttggtcactgatgattccat	9	17	7	8	0	3	2	1	2	2	0	5	3	4	3	2	2	0	1	2	2	2	6			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr15:31234209C>T	uc001zfh.1	-	16	1896	c.1798G>A	c.(1798-1800)GAA>AAA	p.E600K	MTMR15_uc001zff.2_3'UTR|MTMR15_uc001zfe.2_3'UTR|MTMR10_uc010ubk.1_Missense_Mutation_p.E14K|MTMR10_uc001zfg.1_Missense_Mutation_p.E181K|MTMR10_uc010azx.1_Missense_Mutation_p.E352K|MTMR10_uc001zfi.1_3'UTR	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	600	Myotubularin phosphatase.						phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		GGAAGTAATTCTTGGTCACTG	0.408													9	320					0	0	0	0	T	31234209	T	T	31234209	3	4	25	1	0	0	0	0	1	0	0	0	9992	922	32	2	539	2	MTMR10	15	31234209	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08		31234209	71297183	61	5115											
MFGE8	4240	broad.mit.edu	37	chr15	89450552	89450552	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcacacgcacagacgaggcGgcgatctgtgagttggcaat	10	7	14	10	4	2	2	1	1	1	1	2	4	2	2	0	3	0	3	0	3	1	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr15:89450552G>A	uc002bng.3	-	3	374	c.261C>T	c.(259-261)GCC>GCT	p.A87A	MFGE8_uc002bnf.3_5'UTR|MFGE8_uc002bnh.3_Silent_p.A87A|MFGE8_uc010bnn.2_Silent_p.A79A|MFGE8_uc010upq.1_Silent_p.A43A|MFGE8_uc010upr.1_Silent_p.A87A|MFGE8_uc010bno.2_Silent_p.A43A	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	87	F5/8 type C 1.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					CAGACGAGGCGGCGATCTGTG	0.617													23	38					0	0	0	0	A	89450552	A	A	89450552	2	1	25	1	0	0	0	0	0	0	0	1	9573	1103	39	1		1	MFGE8	15	89450552	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08	58216343	89450552	13080840	62	5116											
PPL	5493	broad.mit.edu	37	chr16	4947769	4947769	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgtgcacagcctccatgtgCgcctgccaggaagagaaggg	9	5	15	12	2	0	1	0	0	0	1	1	3	1	2	4	2	4	1	4	2	2	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr16:4947769C>T	uc002cyd.1	-	9	969	c.879G>A	c.(877-879)GCG>GCA	p.A293A		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	293	Potential.|Spectrin 1.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						CCTCCATGTGCGCCTGCCAGG	0.612													3	28					0	0	0	0	T	4947769	T	T	4947769	2	4	25	1	0	0	0	0	0	0	0	1	12394	755	27	1		1	PPL	16	4947769	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08		4947769	85406984	63	5117											
BCKDK	10295	broad.mit.edu	37	chr16	31122691	31122691	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatcaccatcgccaacaatGatgtcgatctgatcatcagg	12	10	7	12	2	5	2	4	2	1	0	7	3	5	2	2	1	1	0	2	1	2	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr16:31122691G>A	uc002eaw.3	+	10	1232	c.916G>A	c.(916-918)GAT>AAT	p.D306N	BCKDK_uc002eav.3_Missense_Mutation_p.D306N|BCKDK_uc010cah.2_RNA|BCKDK_uc010cai.2_Intron	NM_005881	NP_005872	O14874	BCKD_HUMAN	branched chain ketoacid dehydrogenase kinase	306	Histidine kinase.				branched chain family amino acid catabolic process|peptidyl-histidine phosphorylation	mitochondrial alpha-ketoglutarate dehydrogenase complex	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity|ATP binding|protein binding|protein serine/threonine kinase activity|two-component sensor activity			stomach(1)|breast(1)	2						CGCCAACAATGATGTCGATCT	0.507													17	68					0	0	0	0	A	31122691	A	A	31122691	3	1	25	1	0	0	0	0	1	0	0	0	1363	1290	45	2	950	2	BCKDK	16	31122691	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	26174922	31122691	59232062	64	5118											
KIAA0664	23277	broad.mit.edu	37	chr17	2604101	2604101	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatggggtggcgatcctctcGaacgggtggcgctggaccct	6	8	16	11	4	1	0	0	0	1	0	3	3	2	1	2	6	1	1	2	6	2	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:2604101G>A	uc002fuy.1	-	8	1016	c.930C>T	c.(928-930)TTC>TTT	p.F310F	KIAA0664_uc002fux.1_Silent_p.F242F	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	310							binding			breast(2)	2						CGATCCTCTCGAACGGGTGGC	0.682													16	42					0	0	0	0	A	2604101	A	A	2604101	2	1	25	1	0	0	0	0	0	0	0	1	8228	1049	37	1		1	KIAA0664	17	2604101	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08		2604101	78591109	65	5119											
MYH3	4621	broad.mit.edu	37	chr17	10558189	10558189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagccttaccctgttgtcctCagtttccacagtgaccttcc	6	13	7	15	0	1	1	1	1	0	0	4	2	4	1	6	0	2	2	6	0	1	4			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:10558189C>T	uc002gmq.1	-	2	270	c.193G>A	c.(193-195)GAG>AAG	p.E65K		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	65	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CTGTTGTCCTCAGTTTCCACA	0.537													84	300					0	0	0	0	T	10558189	T	T	10558189	3	4	25	1	0	0	0	0	1	0	0	0	10089	835	29	2	5785	2	MYH3	17	10558189	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	7954088	10558189	70637021	66	5120											
AKAP10	11216	broad.mit.edu	37	chr17	19835244	19835244	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accgaatggatgagatcattCaaatatttataataaagatt	18	13	6	4	1	2	2	2	1	0	2	2	5	2	3	1	1	0	0	1	1	7	7			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:19835244C>T	uc002gwo.2	-	10	1652	c.1515G>A	c.(1513-1515)TTG>TTA	p.L505L	AKAP10_uc002gwp.1_Silent_p.L505L|AKAP10_uc010cqw.1_Intron	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	505	RGS 2.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					TGAGATCATTCAAATATTTAT	0.418													15	107					0	0	0	0	T	19835244	T	T	19835244	2	4	25	1	0	0	0	0	0	0	0	1	446	825	29	2		2	AKAP10	17	19835244	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	9277055	19835244	61359966	67	5121											
FOXN1	8456	broad.mit.edu	37	chr17	26851658	26851658	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cactgcccagccggccccggCcctgggcccttcaggctctc	3	6	11	21	2	2	0	1	0	1	0	3	0	2	0	6	4	2	1	6	4	0	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:26851658C>T	uc010crm.2	+	3	459	c.261C>T	c.(259-261)GGC>GGT	p.G87G	FOXN1_uc002hbj.2_Silent_p.G87G	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	87					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					CCGGCCCCGGCCCTGGGCCCT	0.682													18	93					0	0	0	0	T	26851658	T	T	26851658	2	4	25	1	0	0	0	0	0	0	0	1	6053	726	26	4		4	FOXN1	17	26851658	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	7016414	26851658	54343552	68	5122											
GPR179	440435	broad.mit.edu	37	chr17	36491542	36491542	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agccgcacccagcgaagagcGatgcagcggaatacactggg	12	3	14	12	4	0	1	0	0	0	1	0	4	0	2	2	2	6	2	2	2	3	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:36491542G>A	uc002hpz.2	-	6	1359	c.1338C>T	c.(1336-1338)ATC>ATT	p.I446I		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	446	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGCGAAGAGCGATGCAGCGGA	0.443													15	63					0	0	0	0	A	36491542	A	A	36491542	2	1	25	1	0	0	0	0	0	0	0	1	6712	1048	37	1		1	GPR179	17	36491542	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08	9639884	36491542	44703668	69	5123											
GSDMA	284110	broad.mit.edu	37	chr17	38133088	38133088	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggagagcacgatggaacAgaacttcctgctggataaag	13	7	14	7	1	0	2	0	0	0	2	1	6	1	4	1	4	4	2	1	4	4	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:38133088A>G	uc002htl.1	+	12	1233	c.1115A>G	c.(1114-1116)CAG>CGG	p.Q372R	GSDMA_uc002htm.1_Missense_Mutation_p.Q372R	NM_178171	NP_835465	Q96QA5	GSDMA_HUMAN	gasdermin 1	372					apoptosis|induction of apoptosis	perinuclear region of cytoplasm					0						ACGATGGAACAGAACTTCCTG	0.517													30	183					0	0	0	0	G	38133088	G	G	38133088	3	3	25	1	0	0	0	0	1	0	0	0	6855	188	7	5	1157	5	GSDMA	17	38133088	Missense_Mutation	SNP	A	TCGA-BB-4225-01A-01D-1434-08	1641546	38133088	43062122	70	5124											
KRT39	390792	broad.mit.edu	37	chr17	39122694	39122694	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacaggtaatcaggacataGaacagggagctctttgttac	14	9	11	7	0	2	2	1	0	1	2	2	4	2	4	0	3	3	3	0	3	4	4	rs144576097	byFrequency	TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:39122694G>A	uc002hvo.1	-	1	451	c.415C>T	c.(415-417)CTA>TTA	p.L139L	KRT39_uc010wfm.1_5'UTR	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	139	Linker 1.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				TCAGGACATAGAACAGGGAGC	0.423													55	189					0	0	0	0	A	39122694	A	A	39122694	2	1	25	1	0	0	0	0	0	0	0	1	8515	933	33	2		2	KRT39	17	39122694	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08	989606	39122694	42072516	71	5125											
C17orf57	124989	broad.mit.edu	37	chr17	45473259	45473259	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagacgatgagtgtttctGacctgtggaatactctgtct	9	13	12	7	1	3	3	0	2	3	1	3	6	3	4	1	2	1	1	1	2	2	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:45473259G>A	uc002iln.2	+	17	2272	c.1861G>A	c.(1861-1863)GAC>AAC	p.D621N	C17orf57_uc002ilm.2_Missense_Mutation_p.D525N	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	621							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						GAGTGTTTCTGACCTGTGGAA	0.373													27	112					0	0	0	0	A	45473259	A	A	45473259	3	1	25	1	0	0	0	0	1	0	0	0	1872	1290	45	2	1915	2	C17orf57	17	45473259	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	6350565	45473259	35721951	72	5126											
ABCA10	10349	broad.mit.edu	37	chr17	67186544	67186544	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctaggttcaagaatacttCattcagagatgtcactgaaa	14	13	7	7	0	5	3	4	1	1	2	5	4	5	3	0	1	1	1	0	1	5	6			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:67186544C>A	uc010dfa.1	-	19	2965	c.2086G>T	c.(2086-2088)GAA>TAA	p.E696*	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Nonsense_Mutation_p.E297*	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	696					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					AAGAATACTTCATTCAGAGAT	0.333													19	98					3.51602e-12	3.92051e-12	1	0	A	67186544	A	A	67186544	4	1	25	1	0	0	0	0	0	1	0	0	29	835	29	2	2633	2	ABCA10	17	67186544	Nonsense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	21713285	67186544	14008666	73	5127											
KCNJ16	3773	broad.mit.edu	37	chr17	68129405	68129405	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaggagaccaccacttccGccacacatgaatatagggaa	14	6	9	12	1	0	3	0	2	0	1	1	5	1	4	4	2	0	0	4	2	4	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:68129405G>A	uc002jin.2	+	5	1663	c.1177G>A	c.(1177-1179)GCC>ACC	p.A393T	KCNJ16_uc002jio.2_Missense_Mutation_p.A393T|KCNJ16_uc002jip.2_Missense_Mutation_p.A393T|KCNJ16_uc002jiq.2_Missense_Mutation_p.A425T	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	393	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					CACCACTTCCGCCACACATGA	0.458													23	107					0	0	0	0	A	68129405	A	A	68129405	3	1	25	1	0	0	0	0	1	0	0	0	8089	1087	38	1	1179	1	KCNJ16	17	68129405	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	942861	68129405	13065805	74	5128											
FDXR	2232	broad.mit.edu	37	chr17	72862630	72862630	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgtccctgcccacctccaCgttgccccagaaggcacagc	8	5	8	20	2	0	1	0	0	0	1	2	1	2	1	6	1	3	2	6	1	1	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:72862630C>T	uc002jly.2	-	4	418	c.331G>A	c.(331-333)GTG>ATG	p.V111M	FDXR_uc010wri.1_Missense_Mutation_p.V59M|FDXR_uc010wrj.1_Missense_Mutation_p.V109M|FDXR_uc002jlw.2_Translation_Start_Site|FDXR_uc002jlx.2_Missense_Mutation_p.V111M|FDXR_uc002jmc.2_Missense_Mutation_p.V112M|FDXR_uc010wrk.1_Missense_Mutation_p.V142M|FDXR_uc010wrl.1_Missense_Mutation_p.V154M|FDXR_uc002jma.2_Missense_Mutation_p.V112M|FDXR_uc010wrm.1_Intron|FDXR_uc002jlz.2_Missense_Mutation_p.V103M|FDXR_uc002jmb.2_RNA	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	111					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					CCCACCTCCACGTTGCCCCAG	0.652													18	44					0	0	0	0	T	72862630	T	T	72862630	3	4	25	1	0	0	0	0	1	0	0	0	5839	536	19	1	1198	1	FDXR	17	72862630	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	4733225	72862630	8332580	75	5129											
PGS1	9489	broad.mit.edu	37	chr17	76388715	76388715	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcacgttagggtgctttCttccccggcagagtttttcg	4	16	10	11	3	2	1	1	0	2	1	5	1	3	1	2	2	1	4	2	2	1	6			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:76388715C>T	uc002jvm.2	+	2	314	c.302C>T	c.(301-303)TCT>TTT	p.S101F	PGS1_uc010wtt.1_RNA	NM_024419	NP_077733	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	101					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			AGGGTGCTTTCTTCCCCGGCA	0.502													27	141					0	0	0	0	T	76388715	T	T	76388715	3	4	25	1	0	0	0	0	1	0	0	0	11863	913	32	2	308	2	PGS1	17	76388715	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	3526085	76388715	4806495	76	5130											
MAPK4	5596	broad.mit.edu	37	chr18	48190638	48190638	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcagcgtggcgtacatcGtccaggagtacatggagacc	10	8	13	10	3	1	1	1	0	0	1	3	3	2	2	2	3	3	3	2	3	2	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr18:48190638G>A	uc002lev.2	+	2	1310	c.310G>A	c.(310-312)GTC>ATC	p.V104I	MAPK4_uc010xdm.1_Intron|MAPK4_uc010doz.2_Missense_Mutation_p.V104I	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	104	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GGCGTACATCGTCCAGGAGTA	0.612													26	105					0	0	0	0	A	48190638	A	A	48190638	3	1	25	1	0	0	0	0	1	0	0	0	9333	1145	40	1	312	1	MAPK4	18	48190638	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08		48190638	29886610	77	5131											
SALL3	27164	broad.mit.edu	37	chr18	76753935	76753935	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagttcaaggcccagtttccGttcggggggctgctagactc	6	10	13	12	2	1	1	1	0	0	1	4	1	2	1	2	4	1	5	2	4	2	4			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr18:76753935G>A	uc002lmt.2	+	2	1944	c.1944G>A	c.(1942-1944)CCG>CCA	p.P648P	SALL3_uc010dra.2_Silent_p.P255P	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	648					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCCAGTTTCCGTTCGGGGGGC	0.652													3	15					0	0	0	0	A	76753935	A	A	76753935	2	1	25	1	0	0	0	0	0	0	0	1	13877	1132	40	1		1	SALL3	18	76753935	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08	28563297	76753935	1323313	78	5132											
NFATC1	4772	broad.mit.edu	37	chr18	77246917	77246917	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgagagcctgaagagttggAccagttgtacctggatgacg	10	8	15	8	2	0	4	0	2	0	2	0	7	0	6	3	2	2	3	3	2	2	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr18:77246917A>G	uc010xfg.1	+	9	3215	c.2762A>G	c.(2761-2763)GAC>GGC	p.D921G	NFATC1_uc002lnd.2_Intron|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Intron|NFATC1_uc010xfj.1_Missense_Mutation_p.D449G|NFATC1_uc002lnf.2_Missense_Mutation_p.D908G|NFATC1_uc002lng.2_Intron|NFATC1_uc010xfk.1_Intron	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	921	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GAAGAGTTGGACCAGTTGTAC	0.637													3	122					0	0	0	0	G	77246917	G	G	77246917	3	3	25	1	0	0	0	0	1	0	0	0	10415	275	10	5	2947	5	NFATC1	18	77246917	Missense_Mutation	SNP	A	TCGA-BB-4225-01A-01D-1434-08	492982	77246917	830331	79	5133											
ABCA7	10347	broad.mit.edu	37	chr19	1058700	1058700	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatacaggggcccctcttcCttctcttcacactactgctg	6	13	7	15	0	3	1	1	1	2	0	5	1	4	1	3	2	3	1	3	2	2	5			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:1058700C>T	uc002lqw.3	+	38	5464	c.5233C>T	c.(5233-5235)CTT>TTT	p.L1745F	ABCA7_uc002lqy.2_Missense_Mutation_p.L198F|ABCA7_uc010dsc.2_RNA	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1745	Helical; (Potential).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCCTCTTCCTTCTCTTCAC	0.572													31	189					0	0	0	0	T	1058700	T	T	1058700	3	4	25	1	0	0	0	0	1	0	0	0	37	681	24	4	5379	4	ABCA7	19	1058700	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08		1058700	58070283	80	5134											
MUC16	94025	broad.mit.edu	37	chr19	9065980	9065980	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctcatctgaagtgtggcTcagctttggaggtgaactgg	7	13	13	8	0	4	2	2	2	2	0	5	3	4	3	0	4	2	2	0	4	2	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:9065980T>C	uc002mkp.2	-	3	21670	c.21466A>G	c.(21466-21468)AGC>GGC	p.S7156G		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7158	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAGTGTGGCTCAGCTTTGGA	0.502													32	139					0	0	0	0	C	9065980	C	C	9065980	3	2	25	1	0	0	0	0	1	0	0	0	10026	1551	54	5	22385	5	MUC16	19	9065980	Missense_Mutation	SNP	T	TCGA-BB-4225-01A-01D-1434-08	8007280	9065980	50063003	81	5135											
C19orf66	55337	broad.mit.edu	37	chr19	10202783	10202783	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatcctgtgctcaccccaaGagccggaagcagaaccacct	12	5	8	16	1	1	2	1	0	0	2	2	3	2	3	6	1	4	2	6	1	3	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:10202783G>A	uc002mmu.3	+	8	979	c.681G>A	c.(679-681)AAG>AAA	p.K227K	C19orf66_uc002mmv.3_Silent_p.K191K|C19orf66_uc002mmw.3_Silent_p.K176K	NM_018381	NP_060851	Q9NUL5	CS066_HUMAN	hypothetical protein LOC55337	227											0						CTCACCCCAAGAGCCGGAAGC	0.642													29	139					0	0	0	0	A	10202783	A	A	10202783	2	1	25	1	0	0	0	0	0	0	0	1	1955	933	33	2		2	C19orf66	19	10202783	Silent	SNP	G	TCGA-BB-4225-01A-01D-1434-08	1136803	10202783	48926200	82	5136											
CILP2	148113	broad.mit.edu	37	chr19	19654523	19654523	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcctgcgacccccggccccGagagtacctgatcaagctcc	8	5	10	18	3	1	2	1	1	0	1	2	4	2	2	7	1	4	2	7	1	2	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:19654523G>A	uc002nmv.3	+	8	1254	c.1169G>A	c.(1168-1170)CGA>CAA	p.R390Q	CILP2_uc002nmw.3_Missense_Mutation_p.R396Q	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	390						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CCCCGGCCCCGAGAGTACCTG	0.662													125	491					0	0	0	0	A	19654523	A	A	19654523	3	1	25	1	0	0	0	0	1	0	0	0	3445	1058	37	1	1199	1	CILP2	19	19654523	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	9451740	19654523	39474460	83	5137											
DHX34	9704	broad.mit.edu	37	chr19	47856613	47856613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgttaccgcatcaacctctCtgttcttggccctgccacgc	6	11	7	17	3	3	0	1	0	2	0	4	0	3	0	4	1	3	3	4	1	2	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:47856613C>T	uc010xyn.1	+	2	667	c.326C>T	c.(325-327)TCT>TTT	p.S109F	DHX34_uc010elc.1_Missense_Mutation_p.S109F	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	109						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		ATCAACCTCTCTGTTCTTGGC	0.637													52	282					0	0	0	0	T	47856613	T	T	47856613	3	4	25	1	0	0	0	0	1	0	0	0	4529	913	32	2	328	2	DHX34	19	47856613	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	28202090	47856613	11272370	84	5138											
VRK3	51231	broad.mit.edu	37	chr19	50482394	50482394	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggtcatatggagacacaCgcagatcctgcagcaaagct	12	7	12	10	1	1	2	1	0	0	2	2	3	2	2	1	3	3	4	1	3	2	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:50482394C>T	uc002prg.2	-	14	1480	c.1382G>A	c.(1381-1383)CGT>CAT	p.R461H	VRK3_uc002prh.1_Missense_Mutation_p.R461H|VRK3_uc002pri.1_Missense_Mutation_p.R411H|VRK3_uc010ens.2_Missense_Mutation_p.R461H|VRK3_uc010ybl.1_Missense_Mutation_p.R411H|VRK3_uc010ybm.1_Missense_Mutation_p.R230H	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	461						nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		TGGAGACACACGCAGATCCTG	0.572													53	113					0	0	0	0	T	50482394	T	T	50482394	3	4	25	1	0	0	0	0	1	0	0	0	17289	536	19	1	46	1	VRK3	19	50482394	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08	2625781	50482394	8646589	85	5139											
SNRPB	6628	broad.mit.edu	37	chr20	2443804	2443804	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggtgggtactgggttggagCcccggcaatactggctgtgg	6	9	18	8	1	0	0	0	0	0	0	0	1	0	1	2	7	3	4	2	7	3	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr20:2443804C>A	uc002wfz.1	-	5	653	c.490G>T	c.(490-492)GCT>TCT	p.A164S	SNRPB_uc002wga.1_Missense_Mutation_p.A164S|SNRPB_uc010zpv.1_Missense_Mutation_p.A85S|SNRPB_uc002wgb.2_Missense_Mutation_p.A164S|SNORD119_uc010gam.1_5'Flank	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	164					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						TGGGTTGGAGCCCCGGCAATA	0.592													66	154					1.59627e-33	1.7958e-33	1	0	A	2443804	A	A	2443804	3	1	25	1	0	0	0	0	1	0	0	0	14925	739	26	4	259	4	SNRPB	20	2443804	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08		2443804	60581716	86	5140											
RPN2	6185	broad.mit.edu	37	chr20	35827572	35827572	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttggccttcccttggcatcCcaagaagcactcagtgccct	7	11	8	15	0	1	1	1	0	0	1	3	1	3	1	4	2	2	2	4	2	2	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr20:35827572C>T	uc002xgp.2	+	4	727	c.423C>T	c.(421-423)TCC>TCT	p.S141S	RPN2_uc002xgo.3_Silent_p.S141S|RPN2_uc010gfw.2_Intron|RPN2_uc002xgq.2_Silent_p.S109S	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	141	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CCTTGGCATCCCAAGAAGCAC	0.527													11	254					0	0	0	0	T	35827572	T	T	35827572	2	4	25	1	0	0	0	0	0	0	0	1	13673	610	22	4		4	RPN2	20	35827572	Silent	SNP	C	TCGA-BB-4225-01A-01D-1434-08	33383768	35827572	27197948	87	5141											
GNAS	2778	broad.mit.edu	37	chr20	57428501	57428501	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacaacgagcccatccccGtcgagaatgatggcgaggcc	10	5	11	15	4	1	2	1	1	0	1	3	5	2	2	4	2	2	0	4	2	2	0			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr20:57428501G>A	uc002xzw.2	+	1	466	c.181G>A	c.(181-183)GTC>ATC	p.V61I	GNASAS_uc002xzs.1_5'Flank|GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GCCCATCCCCGTCGAGAATGA	0.642			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			10	39					0	0	0	0	A	57428501	A	A	57428501	3	1	25	1	0	0	0	0	1	0	0	0	6547	1145	40	1	925	1	GNAS	20	57428501	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	21600929	57428501	5597019	88	5142											
SIK1	150094	broad.mit.edu	37	chr21	44841623	44841623	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccacggccgacaggatttGccagaacttcttccgcgcct	7	9	9	16	4	1	1	0	0	1	1	3	3	3	2	5	2	2	0	5	2	1	3			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr21:44841623G>T	uc002zdf.2	-	5	521	c.394C>A	c.(394-396)CAA>AAA	p.Q132K		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	132	Protein kinase.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						GACAGGATTTGCCAGAACTTC	0.552													15	36					2.32078e-09	2.56508e-09	1	0	T	44841623	T	T	44841623	3	4	25	1	0	0	0	0	1	0	0	0	14382	1328	46	4	1997	4	SIK1	21	44841623	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08		44841623	3288272	89	5143											
GRAMD4	23151	broad.mit.edu	37	chr22	47062766	47062766	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtgcccgaagtgtctgagcCcgtggtaagtccctggaggg	6	8	16	11	3	1	1	0	1	1	0	2	3	2	2	3	3	2	1	3	3	2	1			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr22:47062766C>G	uc003bhx.2	+	9	893	c.854C>G	c.(853-855)CCC>CGC	p.P285R	GRAMD4_uc010had.2_Missense_Mutation_p.P224R	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	285					apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		GTGTCTGAGCCCGTGGTAAGT	0.617													3	151					0	0	0	0	G	47062766	G	G	47062766	3	3	25	1	0	0	0	0	1	0	0	0	6791	623	22	4	888	4	GRAMD4	22	47062766	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08		47062766	4241800	90	5144											
ACR	49	broad.mit.edu	37	chr22	51183225	51183225	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccctatctgaactggatcGcctccaagattggttctaac	9	11	9	12	1	2	2	0	1	2	1	4	3	3	3	3	3	2	1	3	3	4	4			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr22:51183225G>A	uc003bnh.3	+	5	868	c.856G>A	c.(856-858)GCC>ACC	p.A286T		NM_001097	NP_001088	P10323	ACRO_HUMAN	acrosin precursor	286	Peptidase S1.				acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		GAACTGGATCGCCTCCAAGAT	0.622													9	12					0	0	0	0	A	51183225	A	A	51183225	3	1	25	1	0	0	0	0	1	0	0	0	169	1087	38	1	874	1	ACR	22	51183225	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08	4120459	51183225	121341	91	5145											
MAGEB10	139422	broad.mit.edu	37	chrX	27840150	27840150	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttgagcacttcatgtttgggGagcccaggaagctccttacc	8	11	11	11	0	1	1	1	1	0	0	2	3	2	3	3	3	4	3	3	3	2	4			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chrX:27840150G>A	uc004dbw.2	+	3	954	c.727G>A	c.(727-729)GAG>AAG	p.E243K		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	243	MAGE.									lung(1)|breast(1)|central_nervous_system(1)	3						CATGTTTGGGGAGCCCAGGAA	0.453													6	54					0	0	0	0	A	27840150	A	A	27840150	3	1	25	1	0	0	0	0	1	0	0	0	9226	1175	41	2	729	2	MAGEB10	23	27840150	Missense_Mutation	SNP	G	TCGA-BB-4225-01A-01D-1434-08		27840150	127430410	92	5146											
NLGN4Y	22829	broad.mit.edu	37	chrY	16952550	16952550	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctccaccagacatgacatCatttccctatggcacccggc	9	9	6	17	1	1	2	1	1	0	1	4	2	4	2	5	2	0	1	5	2	1	2			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chrY:16952550C>T	uc004ftg.2	+	6	2111	c.1859C>T	c.(1858-1860)TCA>TTA	p.S620L	NLGN4Y_uc004fte.2_Missense_Mutation_p.S452L|NLGN4Y_uc011nas.1_Missense_Mutation_p.S640L|NLGN4Y_uc004ftf.2_Missense_Mutation_p.S313L|NLGN4Y_uc004fth.2_Missense_Mutation_p.S620L	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	620	Extracellular (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						GACATGACATCATTTCCCTAT	0.493													30	33					0	0	0	0	T	16952550	T	T	16952550	3	4	25	1	0	0	0	0	1	0	0	0	10519	838	29	2	2031	2	NLGN4Y	24	16952550	Missense_Mutation	SNP	C	TCGA-BB-4225-01A-01D-1434-08		16952550	42421016	93	5147											
SKI	6497	broad.mit.edu	37	chr1	2160775	2160775	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcctgtgcaacgcgctgctCtacggcggcgcctacccgcc	4	6	12	19	7	1	0	0	0	1	0	1	0	1	0	4	2	5	3	4	2	3	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:2160775C>T	uc001aja.3	+	1	642	c.570C>T	c.(568-570)CTC>CTT	p.L190L		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	190					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		ACGCGCTGCTCTACGGCGGCG	0.692													4	10					0	0	0	0	T	2160775	T	T	2160775	2	4	26	1	0	0	0	0	0	0	0	1	14422	900	32	2		2	SKI	1	2160775	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08		2160775	247089846	1	5148											
ASAP3	55616	broad.mit.edu	37	chr1	23759683	23759683	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggtggctgctcccaggctgGcgacagtctcataggtcttg	5	10	15	11	1	2	0	1	0	2	0	4	1	3	0	1	5	1	3	1	5	1	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:23759683G>A	uc001bha.2	-	22	2334	c.2210C>T	c.(2209-2211)GCC>GTC	p.A737V	ASAP3_uc001bgy.1_Missense_Mutation_p.A241V|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Missense_Mutation_p.A627V|ASAP3_uc010oea.1_Missense_Mutation_p.A728V|ASAP3_uc001bhb.2_Missense_Mutation_p.A260V	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	737					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						TCCCAGGCTGGCGACAGTCTC	0.602													81	93					0	0	0	0	A	23759683	A	A	23759683	3	1	26	1	0	0	0	0	1	0	0	0	1014	1203	42	4	517	4	ASAP3	1	23759683	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	21598908	23759683	225490938	2	5149											
C1orf91	56063	broad.mit.edu	37	chr1	32682865	32682865	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agtagtctaacttacgttttCcaccaatatcttctccaagg	11	14	5	11	1	3	0	0	0	3	0	5	0	4	0	3	1	2	2	3	1	6	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:32682865C>G	uc009vub.1	-	4	326	c.323G>C	c.(322-324)GGA>GCA	p.G108A	C1orf91_uc001buo.3_RNA|C1orf91_uc001bup.3_RNA|C1orf91_uc010oha.1_RNA|C1orf91_uc001buq.3_Missense_Mutation_p.G108A			Q8WY98	TM234_HUMAN	RecName: Full=UPF0546 membrane protein C1orf91;	108						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CTTACGTTTTCCACCAATATC	0.522													29	48					0	0	0	0	G	32682865	G	G	32682865	3	3	26	1	0	0	0	0	1	0	0	0	2078	855	30	2	107	2	C1orf91	1	32682865	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	8923182	32682865	216567756	3	5150											
KIAA1522	57648	broad.mit.edu	37	chr1	33236757	33236757	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccctgggtgacaggtttgtCatacctcctcaccccaaggt	7	10	9	15	0	2	1	2	1	0	0	3	1	3	1	6	3	1	1	6	3	2	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:33236757C>G	uc001bvv.2	+	6	1936	c.1800C>G	c.(1798-1800)GTC>GTG	p.V600V	KIAA1522_uc001bvu.1_Silent_p.V659V|KIAA1522_uc010ohm.1_Silent_p.V611V|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	600	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				ACAGGTTTGTCATACCTCCTC	0.632													80	103					0	0	0	0	G	33236757	G	G	33236757	2	3	26	1	0	0	0	0	0	0	0	1	8277	813	29	2		2	KIAA1522	1	33236757	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	553892	33236757	216013864	4	5151											
CSMD2	114784	broad.mit.edu	37	chr1	34258100	34258100	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcatagcccctctccaaatCaaactcctcaaaggcgagct	12	8	6	15	1	4	0	3	0	1	0	6	1	5	0	4	1	3	1	4	1	4	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:34258100C>G	uc001bxn.1	-	11	1383	c.1354G>C	c.(1354-1356)GAT>CAT	p.D452H	CSMD2_uc001bxm.1_Missense_Mutation_p.D492H	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	452	CUB 3.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTCTCCAAATCAAACTCCTCA	0.552													29	65					0	0	0	0	G	34258100	G	G	34258100	3	3	26	1	0	0	0	0	1	0	0	0	3962	826	29	2	9345	2	CSMD2	1	34258100	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1021343	34258100	214992521	5	5152											
INPP5B	3633	broad.mit.edu	37	chr1	38339682	38339682	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctggcaggaggaagcctCtgctggggttggcattcagc	7	9	15	10	0	2	0	1	0	1	0	2	2	2	2	2	6	4	4	2	6	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:38339682C>T	uc001ccg.1	-	18	2028	c.1934G>A	c.(1933-1935)AGA>AAA	p.R645K	INPP5B_uc009vvk.1_Missense_Mutation_p.R586K|INPP5B_uc001ccf.1_Missense_Mutation_p.R481K|INPP5B_uc010oij.1_RNA	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	725					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GAGGAAGCCTCTGCTGGGGTT	0.438													18	18					0	0	0	0	T	38339682	T	T	38339682	3	4	26	1	0	0	0	0	1	0	0	0	7794	913	32	2	835	2	INPP5B	1	38339682	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	4081582	38339682	210910939	6	5153											
RLF	6018	broad.mit.edu	37	chr1	40627251	40627251	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcagctggagacagagctGagggagcaagaggtgtcgga	11	5	19	6	1	0	4	0	1	0	3	1	7	0	6	0	5	3	4	0	5	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:40627251G>A	uc001cfc.3	+	1	211	c.180G>A	c.(178-180)CTG>CTA	p.L60L		NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	60					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AGACAGAGCTGAGGGAGCAAG	0.617													32	43					0	0	0	0	A	40627251	A	A	40627251	2	1	26	1	0	0	0	0	0	0	0	1	13454	1277	45	2		2	RLF	1	40627251	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2287569	40627251	208623370	7	5154											
COL9A2	1298	broad.mit.edu	37	chr1	40775622	40775622	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggactcacctcgtcacccttCtccccagctcggcctggcgg	4	8	10	19	3	3	0	2	0	1	0	6	1	3	1	5	4	1	1	5	4	0	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:40775622C>G	uc001cfh.1	-	16	904	c.834G>C	c.(832-834)GAG>GAC	p.E278D	COL9A2_uc001cfi.1_Missense_Mutation_p.E97D	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	278	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CGTCACCCTTCTCCCCAGCTC	0.587													50	81					0	0	0	0	G	40775622	G	G	40775622	3	3	26	1	0	0	0	0	1	0	0	0	3723	912	32	2	1303	2	COL9A2	1	40775622	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	148371	40775622	208474999	8	5155											
TOE1	114034	broad.mit.edu	37	chr1	45808853	45808853	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcagaggacaagcggcgaCggcgacgacgtagggaaaaa	14	1	17	9	7	0	1	0	0	0	1	0	6	0	3	0	5	1	2	0	5	4	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:45808853C>T	uc009vxq.2	+	8	1595	c.1012C>T	c.(1012-1014)CGG>TGG	p.R338W	MUTYH_uc001cno.2_5'Flank|MUTYH_uc001cnk.2_5'Flank|MUTYH_uc010oll.1_5'Flank|MUTYH_uc001cnm.2_5'Flank|MUTYH_uc001cnl.2_5'Flank|MUTYH_uc009vxp.2_5'Flank|MUTYH_uc001cnn.2_5'Flank|TOE1_uc001cnq.3_RNA|TOE1_uc010olm.1_Missense_Mutation_p.R258W|TOE1_uc001cnr.3_RNA	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	338	Nuclear localization signal.					nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)					CAAGCGGCGACGGCGACGACG	0.567													81	129					0	0	0	0	T	45808853	T	T	45808853	3	4	26	1	0	0	0	0	1	0	0	0	16415	527	19	1	1042	1	TOE1	1	45808853	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	5033231	45808853	203441768	9	5156											
PARS2	25973	broad.mit.edu	37	chr1	55224213	55224213	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggagtcaaaggtgtacatatCcttcatgtaaaactctcggc	12	11	9	9	1	3	0	2	0	1	0	5	1	4	1	1	3	2	2	1	3	5	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:55224213C>G	uc001cxy.2	-	2	705	c.622G>C	c.(622-624)GAT>CAT	p.D208H		NM_152268	NP_689481	Q7L3T8	SYPM_HUMAN	prolyl-tRNA synthetase (mitochondrial)(putative)	208					prolyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|proline-tRNA ligase activity			ovary(2)	2					L-Proline(DB00172)	GTGTACATATCCTTCATGTAA	0.552													54	56					0	0	0	0	G	55224213	G	G	55224213	3	3	26	1	0	0	0	0	1	0	0	0	11521	855	30	2	809	2	PARS2	1	55224213	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	9415360	55224213	194026408	10	5157											
SGIP1	84251	broad.mit.edu	37	chr1	67109271	67109271	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcaagtgaatcggaagaaGaagaagaatcacataagaaa	21	6	9	5	1	2	6	2	1	0	5	3	7	2	7	0	1	0	0	0	1	9	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:67109271G>A	uc001dcr.2	+	7	545	c.328G>A	c.(328-330)GAA>AAA	p.E110K	SGIP1_uc010opd.1_5'UTR|SGIP1_uc001dcs.2_5'UTR|SGIP1_uc001dct.2_5'UTR	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	110	Poly-Glu.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						ATCGGAAGAAGAAGAAGAATC	0.343													22	39					0	0	0	0	A	67109271	A	A	67109271	3	1	26	1	0	0	0	0	1	0	0	0	14271	943	33	2	354	2	SGIP1	1	67109271	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	11885058	67109271	182141350	11	5158											
ODF2L	57489	broad.mit.edu	37	chr1	86818601	86818601	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttctttctaagctcagtttCcagatctaatattttaattt	10	21	3	7	0	4	1	1	0	3	1	5	1	5	1	1	0	1	2	1	0	4	9	rs149282656	byFrequency	TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:86818601C>G	uc001dll.1	-	17	2174	c.1834G>C	c.(1834-1836)GAA>CAA	p.E612Q	ODF2L_uc001dlm.1_Missense_Mutation_p.E596Q|ODF2L_uc001dln.2_Missense_Mutation_p.E583Q|ODF2L_uc001dlo.2_Missense_Mutation_p.E452Q|ODF2L_uc001dlp.2_Missense_Mutation_p.E559Q|ODF2L_uc010osg.1_Missense_Mutation_p.E530Q	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	612	Potential.					centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		AGCTCAGTTTCCAGATCTAAT	0.279													23	31					0	0	0	0	G	86818601	G	G	86818601	3	3	26	1	0	0	0	0	1	0	0	0	10882	864	30	2	217	2	ODF2L	1	86818601	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	19709330	86818601	162432020	12	5159											
CCDC76	54482	broad.mit.edu	37	chr1	100613702	100613702	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tttcagggctctaggccttgGagcagtggaattccattatt	8	14	11	8	0	2	0	1	0	1	0	3	2	3	2	2	4	1	2	2	4	3	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:100613702G>T	uc001dsv.2	+	10	1089	c.1070G>T	c.(1069-1071)GGA>GTA	p.G357V	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Intron	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	357					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		CTAGGCCTTGGAGCAGTGGAA	0.458													19	39					1.96292e-10	2.04633e-10	1	0	T	100613702	T	T	100613702	3	4	26	1	0	0	0	0	1	0	0	0	2863	1174	41	2	1108	2	CCDC76	1	100613702	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	13795101	100613702	148636919	13	5160											
PROK1	84432	broad.mit.edu	37	chr1	110998955	110998955	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccgctgctccatggacttGaagaacatcaatttttaggc	11	12	8	10	1	1	2	1	1	0	1	2	3	2	3	2	2	3	2	2	2	5	5	rs148436202		TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:110998955G>C	uc001dzs.2	+	3	351	c.300G>C	c.(298-300)TTG>TTC	p.L100F		NM_032414	NP_115790	P58294	PROK1_HUMAN	prokineticin 1 precursor	100					angiogenesis|positive regulation of cell division	extracellular region	growth factor activity				0		all_cancers(81;6.23e-06)|all_epithelial(167;2.12e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0239)|all cancers(265;0.0699)|Epithelial(280;0.0753)|Colorectal(144;0.105)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCATGGACTTGAAGAACATCA	0.537													9	94					0	0	0	0	C	110998955	C	C	110998955	3	2	26	1	0	0	0	0	1	0	0	0	12612	1281	45	2	310	2	PROK1	1	110998955	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	10385253	110998955	138251666	14	5161											
FAM19A3	284467	broad.mit.edu	37	chr1	113265703	113265703	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgcaaccggaaccgcatcGaggagcgctcccagacggtg	9	4	14	14	5	0	1	0	0	0	1	2	4	1	3	3	3	4	4	3	3	2	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:113265703G>A	uc001ecv.2	+	3	250	c.181G>A	c.(181-183)GAG>AAG	p.E61K	FAM19A3_uc001ecu.2_Missense_Mutation_p.E61K|FAM19A3_uc010owk.1_RNA|FAM19A3_uc010owl.1_RNA	NM_182759	NP_877436	Q7Z5A8	F19A3_HUMAN	family with sequence similarity 19 (chemokine	61						extracellular region					0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACCGCATCGAGGAGCGCTC	0.657													16	22					0	0	0	0	A	113265703	A	A	113265703	3	1	26	1	0	0	0	0	1	0	0	0	5561	1059	37	1	187	1	FAM19A3	1	113265703	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2266748	113265703	135984918	15	5162											
CSDE1	7812	broad.mit.edu	37	chr1	115275262	115275262	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtgaactgaaatgtatttGacagaacttctatattggtt	13	16	8	4	0	1	4	0	3	1	1	1	4	1	4	0	1	2	2	0	1	7	8			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:115275262G>C	uc001efk.2	-	10	1479	c.1013C>G	c.(1012-1014)TCA>TGA	p.S338*	CSDE1_uc001efi.2_Nonsense_Mutation_p.S384*|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Nonsense_Mutation_p.S307*|CSDE1_uc001efm.2_Nonsense_Mutation_p.S353*|CSDE1_uc009wgv.2_Nonsense_Mutation_p.S338*|CSDE1_uc001efn.2_Nonsense_Mutation_p.S307*	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	338					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATGTATTTGACAGAACTTC	0.373													13	108					0	0	0	0	C	115275262	C	C	115275262	4	2	26	1	0	0	0	0	0	1	0	0	3946	1294	45	2	1427	2	CSDE1	1	115275262	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2009559	115275262	133975359	16	5163											
IGSF3	3321	broad.mit.edu	37	chr1	117158899	117158899	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cataggggaaggaagagtccAtggtgctgacgatctgcacc	11	7	14	9	1	1	2	0	1	1	1	2	5	2	4	2	4	2	2	2	4	3	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:117158899A>G	uc001egr.1	-	3	929	c.224T>C	c.(223-225)ATG>ACG	p.M75T	IGSF3_uc001egq.1_Missense_Mutation_p.M75T	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	75	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GGAAGAGTCCATGGTGCTGAC	0.542													3	48					0	0	0	0	G	117158899	G	G	117158899	3	3	26	1	0	0	0	0	1	0	0	0	7640	217	8	5	3460	5	IGSF3	1	117158899	Missense_Mutation	SNP	A	TCGA-BB-4227-01A-01D-1870-08	1883637	117158899	132091722	17	5164											
CD101	9398	broad.mit.edu	37	chr1	117554213	117554213	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaccatgagttctcagactCtcggtaaggaggaaggtgag	11	8	13	9	1	2	3	1	2	2	1	4	5	2	5	2	4	0	2	2	4	2	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:117554213C>G	uc010oxb.1	+	3	524	c.466C>G	c.(466-468)CTC>GTC	p.L156V	CD101_uc009whd.2_Missense_Mutation_p.L156V|CD101_uc010oxc.1_Missense_Mutation_p.L156V|CD101_uc010oxd.1_Intron	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	156	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TTCTCAGACTCTCGGTAAGGA	0.512													39	73					0	0	0	0	G	117554213	G	G	117554213	3	3	26	1	0	0	0	0	1	0	0	0	2977	913	32	2	476	2	CD101	1	117554213	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	395314	117554213	131696408	18	5165											
FAM46C	54855	broad.mit.edu	37	chr1	118165574	118165574	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttagccggctgcatgaggtCctcactgaagttgtacctat	8	12	11	10	1	1	2	1	2	0	0	2	2	2	2	3	2	3	5	3	2	4	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:118165574C>A	uc001ehe.2	+	2	283	c.84C>A	c.(82-84)GTC>GTA	p.V28V		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	28											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		TGCATGAGGTCCTCACTGAAG	0.557										Multiple Myeloma(3;1.13e-06)			14	64					1.49906e-05	1.52813e-05	1	0	A	118165574	A	A	118165574	2	1	26	1	0	0	0	0	0	0	0	1	5599	842	30	2		2	FAM46C	1	118165574	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	611361	118165574	131085047	19	5166											
ZNF697	90874	broad.mit.edu	37	chr1	120165544	120165544	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgagcgtggagaagtcgctGaagcgcttctcgcactggcc	7	8	15	11	4	1	3	0	2	1	1	3	4	1	3	1	2	2	3	1	2	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:120165544G>A	uc001ehy.1	-	3	1536	c.1422C>T	c.(1420-1422)TTC>TTT	p.F474F		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	474	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		AGAAGTCGCTGAAGCGCTTCT	0.647													14	9					0	0	0	0	A	120165544	A	A	120165544	2	1	26	1	0	0	0	0	0	0	0	1	18167	1281	45	2		2	ZNF697	1	120165544	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1999970	120165544	129085077	20	5167											
PIAS3	10401	broad.mit.edu	37	chr1	145581457	145581458	+	Nonsense_Mutation	DNP	GC	TT	TT																															gccctcacctgcgcccacctGcagagcttcgatgctgccct																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:145581457_145581458GC>TT	uc001eoc.1	+	9	1129_1130	c.1038_1039GC>TT	c.(1036-1041)CTGCAG>CTTTAG	p.Q347*	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_Nonsense_Mutation_p.Q16*	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	347	SP-RING-type.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCGCCCACCTGCAGAGCTTCGA	0.505													90	73					0	0	0	0	TT	145581458	TT	TT	145581457	4	4	26	1	0	0	0	0	0	1	0	0	11932	1306	46	4	1072	4	PIAS3	1	145581457	Nonsense_Mutation	DNP	GC	TCGA-BB-4227-01A-01D-1870-08	25415913	145581457	103669164	21	5168											
ADAMTSL4	54507	broad.mit.edu	37	chr1	150525982	150525982	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgccactgcaccggaaccGcaggcaccctcggagcccac	9	4	10	18	3	0	0	0	0	0	0	1	2	0	2	5	3	4	3	5	3	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:150525982G>A	uc001eux.2	+	6	751	c.515G>A	c.(514-516)CGC>CAC	p.R172H	ADAMTSL4_uc001euw.2_Missense_Mutation_p.R172H|ADAMTSL4_uc009wlw.2_Missense_Mutation_p.R172H|ADAMTSL4_uc010pcg.1_Missense_Mutation_p.R172H	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	172					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CACCGGAACCGCAGGCACCCT	0.577													5	153					0	0	0	0	A	150525982	A	A	150525982	3	1	26	1	0	0	0	0	1	0	0	0	277	1087	38	1	529	1	ADAMTSL4	1	150525982	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	4944525	150525982	98724639	22	5169											
FAM63A	55793	broad.mit.edu	37	chr1	150972984	150972984	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtatgcctagcaggtcaaaGacactgcactcgggtgtata	11	9	12	9	1	1	1	1	0	0	1	2	1	1	1	1	3	3	4	1	3	5	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:150972984G>C	uc001ewf.2	-	6	2368	c.684C>G	c.(682-684)GTC>GTG	p.V228V	FAM63A_uc001ewc.2_Silent_p.V86V|FAM63A_uc010pcm.1_Silent_p.V133V|FAM63A_uc001ewd.2_Silent_p.V86V|FAM63A_uc001ewe.2_Silent_p.V62V|FAM63A_uc010pcn.1_Silent_p.V276V|FAM63A_uc001ewg.2_Silent_p.V228V	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	228							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCAGGTCAAAGACACTGCACT	0.527													45	112					0	0	0	0	C	150972984	C	C	150972984	2	2	26	1	0	0	0	0	0	0	0	1	5628	929	33	2		2	FAM63A	1	150972984	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	447002	150972984	98277637	23	5170											
FLG2	388698	broad.mit.edu	37	chr1	152327320	152327320	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagccagaggattttcctGagcctgactcatgttgtcca	10	11	9	11	0	1	3	1	2	0	1	3	4	3	4	4	1	2	1	4	1	1	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:152327320G>C	uc001ezw.3	-	3	3015	c.2942C>G	c.(2941-2943)TCA>TGA	p.S981*	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	981	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGATTTTCCTGAGCCTGACTC	0.493													12	592					0	0	0	0	C	152327320	C	C	152327320	4	2	26	1	0	0	0	0	0	1	0	0	5955	1294	45	2	4237	2	FLG2	1	152327320	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1354336	152327320	96923301	24	5171											
S100A4	6275	broad.mit.edu	37	chr1	153516241	153516241	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcagaggagttttcatttCttcctgggctgcttatctgg	6	16	10	9	0	4	1	2	0	2	1	5	2	5	2	1	3	1	3	1	3	1	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:153516241C>G	uc001fby.2	-	4	418	c.300G>C	c.(298-300)AAG>AAC	p.K100N	S100A5_uc001fbx.2_5'Flank|S100A4_uc001fbz.2_Missense_Mutation_p.K100N|uc009wog.1_5'Flank	NM_019554	NP_062427	P26447	S10A4_HUMAN	S100 calcium-binding protein A4	100					epithelial to mesenchymal transition|positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus|perinuclear region of cytoplasm	calcium ion binding|RAGE receptor binding				0	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTTTTCATTTCTTCCTGGGCT	0.527													85	274					0	0	0	0	G	153516241	G	G	153516241	3	3	26	1	0	0	0	0	1	0	0	0	13845	912	32	2	9	2	S100A4	1	153516241	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1188921	153516241	95734380	25	5172											
NPR1	4881	broad.mit.edu	37	chr1	153665640	153665640	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctggaggagtttggtggtttCgagctggagcttcgagggga	6	11	19	5	2	0	0	0	0	0	0	2	6	0	4	0	7	2	4	0	7	0	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:153665640C>G	uc001fcs.3	+	21	3511	c.3090C>G	c.(3088-3090)TTC>TTG	p.F1030L	NPR1_uc010pdz.1_Missense_Mutation_p.F776L|NPR1_uc010pea.1_Missense_Mutation_p.F508L	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	1030	Cytoplasmic (Potential).				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	TTGGTGGTTTCGAGCTGGAGC	0.552													41	112					0	0	0	0	G	153665640	G	G	153665640	3	3	26	1	0	0	0	0	1	0	0	0	10648	883	31	3	3172	3	NPR1	1	153665640	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	149399	153665640	95584981	26	5173											
DCST2	127579	broad.mit.edu	37	chr1	155002952	155002952	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggcgtggtgaagcccatCagagccagggcctctcggac	9	5	15	12	2	2	3	1	1	1	2	3	4	2	4	3	4	2	0	3	4	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:155002952C>G	uc001fgm.2	-	6	1055	c.975G>C	c.(973-975)CTG>CTC	p.L325L	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	325	Helical; (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGAAGCCCATCAGAGCCAGGG	0.662													5	69					0	0	0	0	G	155002952	G	G	155002952	2	3	26	1	0	0	0	0	0	0	0	1	4320	813	29	2		2	DCST2	1	155002952	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1337312	155002952	94247669	27	5174											
BCAN	63827	broad.mit.edu	37	chr1	156626846	156626846	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccggatgtacggcgcgcatCtggccagcatcagcacaccc	8	5	12	16	4	2	0	1	0	1	0	2	1	2	1	3	3	3	4	3	3	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:156626846C>G	uc001fpp.2	+	10	2503	c.2167C>G	c.(2167-2169)CTG>GTG	p.L723V		NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	723	C-type lectin.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGGCGCGCATCTGGCCAGCAT	0.597													29	86					0	0	0	0	G	156626846	G	G	156626846	3	3	26	1	0	0	0	0	1	0	0	0	1347	912	32	2	2275	2	BCAN	1	156626846	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1623894	156626846	92623775	28	5175											
HDGF	3068	broad.mit.edu	37	chr1	156713644	156713648	+	Frame_Shift_Del	DEL	TGCCT	-	-																															tcctctccttcagggttttcTgcctccttgggacgtttagg																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:156713644_156713648delTGCCT	uc001fpy.3	-	5	834_838	c.512_516delAGGCA	c.(511-516)GAGGCAfs	p.E171fs	MRPL24_uc001fpw.1_5'Flank|MRPL24_uc001fpx.1_5'Flank|HDGF_uc009wsd.2_Frame_Shift_Del_p.E139fs|HDGF_uc001fpz.3_Frame_Shift_Del_p.E164fs|HDGF_uc009wse.2_Frame_Shift_Del_p.E187fs|HDGF_uc010phr.1_Frame_Shift_Del_p.E194fs|HDGF_uc009wsf.2_Frame_Shift_Del_p.E139fs|HDGF_uc009wsg.2_Frame_Shift_Del_p.E171fs	NM_004494	NP_004485	P51858	HDGF_HUMAN	hepatoma-derived growth factor isoform a	171_172	Glu-rich.				cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			lung(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		CAGGGTTTTCTGCCTCCTTGGGACG	0.605													---	---	---								-	156713648	-	-	156713644	7	5	26	1	0	1	0	1	0	0	0	0	7057	1567	55	0	214	0	HDGF	1	156713644	Frame_Shift_Del	DEL	TGCCT	TCGA-BB-4227-01A-01D-1870-08	86798	156713644	92536977	29	5176											
OR6N1	128372	broad.mit.edu	37	chr1	158735618	158735618	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagctgtagatgaaggggttGaggaagggtgtgagcactga	12	8	18	3	0	0	5	0	4	0	1	0	6	0	6	0	4	2	4	0	4	4	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:158735618G>A	uc010piq.1	-	1	855	c.855C>T	c.(853-855)CTC>CTT	p.L285L		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TGAAGGGGTTGAGGAAGGGTG	0.517													72	200					0	0	0	0	A	158735618	A	A	158735618	2	1	26	1	0	0	0	0	0	0	0	1	11260	1277	45	2		2	OR6N1	1	158735618	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2021974	158735618	90515003	30	5177											
TBX19	9095	broad.mit.edu	37	chr1	168281973	168281973	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgtgcctgtggaccatcagCaatggtgccggaggccccag	7	6	14	14	2	1	0	1	0	0	0	1	2	1	2	6	4	3	1	6	4	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:168281973C>T	uc001gfl.2	+	8	1131	c.1080C>T	c.(1078-1080)AGC>AGT	p.S360S	TBX19_uc001gfj.3_Silent_p.S228S|TBX19_uc001gfm.2_Silent_p.S63S	NM_005149	NP_005140	O60806	TBX19_HUMAN	T-box 19	360					anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)					GGACCATCAGCAATGGTGCCG	0.617													35	83					0	0	0	0	T	168281973	T	T	168281973	2	4	26	1	0	0	0	0	0	0	0	1	15720	709	25	4		4	TBX19	1	168281973	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	9546355	168281973	80968648	31	5178											
ABL2	27	broad.mit.edu	37	chr1	179095631	179095631	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggaagctgccattgattaGactgctgagcagatactcag	12	9	11	9	0	1	4	1	2	0	2	1	5	1	5	1	1	5	3	1	1	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:179095631G>A	uc001gmj.3	-	4	855	c.568C>T	c.(568-570)CTA>TTA	p.L190L	ABL2_uc010pnf.1_Silent_p.L190L|ABL2_uc010png.1_Silent_p.L169L|ABL2_uc010pnh.1_Silent_p.L169L|ABL2_uc009wxe.2_Silent_p.L169L|ABL2_uc001gmg.3_Silent_p.L175L|ABL2_uc001gmi.3_Silent_p.L175L|ABL2_uc001gmh.3_Silent_p.L154L|ABL2_uc010pne.1_Silent_p.L154L|ABL2_uc009wxf.1_Silent_p.L175L|ABL2_uc001gmk.2_Silent_p.L154L	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	190	SH2.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.A190T(1)		lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CCATTGATTAGACTGCTGAGC	0.537			T	ETV6	AML								48	140					0	0	0	0	A	179095631	A	A	179095631	2	1	26	1	0	0	0	0	0	0	0	1	93	933	33	2		2	ABL2	1	179095631	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	10813658	179095631	70154990	32	5179											
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200818403	200818403	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaggagcaagtcactggcaGatataaaagagagcatggag	18	5	13	5	0	1	2	1	0	0	2	1	5	1	4	0	3	2	3	0	3	5	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:200818403G>C	uc001gvl.2	+	12	2809	c.2539G>C	c.(2539-2541)GAT>CAT	p.D847H	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.D836H|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.D820H	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	847						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GTCACTGGCAGATATAAAAGA	0.453													48	153					0	0	0	0	C	200818403	C	C	200818403	3	2	26	1	0	0	0	0	1	0	0	0	2624	942	33	2	2548	2	CAMSAP1L1	1	200818403	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	21722772	200818403	48432218	33	5180											
KLHL12	59349	broad.mit.edu	37	chr1	202864773	202864773	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actaaggcgggaacggccatCatagccaccaatgacgtaga	14	5	11	11	3	1	2	1	1	0	1	1	3	1	3	3	3	2	1	3	3	5	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:202864773C>T	uc001gyo.1	-	8	1212	c.1012G>A	c.(1012-1014)GAT>AAT	p.D338N	KLHL12_uc001gym.1_Missense_Mutation_p.D71N|KLHL12_uc001gyn.1_Missense_Mutation_p.D188N|KLHL12_uc010pqc.1_Missense_Mutation_p.D376N|KLHL12_uc009xah.1_Intron	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	338	Kelch 2.				Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			GAACGGCCATCATAGCCACCA	0.507													24	69					0	0	0	0	T	202864773	T	T	202864773	3	4	26	1	0	0	0	0	1	0	0	0	8407	826	29	2	714	2	KLHL12	1	202864773	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	2046370	202864773	46385848	34	5181											
MYBPH	4608	broad.mit.edu	37	chr1	203144777	203144777	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcttctctggtggactctGatactgccacttctccggga	5	13	10	13	1	4	1	0	1	4	0	6	3	4	3	2	3	2	1	2	3	1	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:203144777G>C	uc001gzh.1	-	1	166	c.107C>G	c.(106-108)TCA>TGA	p.S36*	FMOD_uc010pqi.1_Intron	NM_004997	NP_004988	Q13203	MYBPH_HUMAN	myosin binding protein H	36					cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle				0			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		GGTGGACTCTGATACTGCCAC	0.622													85	218					0	0	0	0	C	203144777	C	C	203144777	4	2	26	1	0	0	0	0	0	1	0	0	10067	1294	45	2	1366	2	MYBPH	1	203144777	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	280004	203144777	46105844	35	5182											
FLVCR1	28982	broad.mit.edu	37	chr1	213032530	213032530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaccgccgtgctgggcaatCaggtaagtactggagtggta	9	8	14	10	2	1	0	1	0	0	0	1	1	1	1	3	4	2	5	3	4	4	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:213032530C>G	uc001hjt.2	+	1	934	c.736C>G	c.(736-738)CAG>GAG	p.Q246E	LQK1_uc001hjr.3_5'Flank|LQK1_uc001hjs.3_5'Flank	NM_014053	NP_054772	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular	246	Helical; (Potential).				cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		GCTGGGCAATCAGGTAAGTAC	0.562													40	112					0	0	0	0	G	213032530	G	G	213032530	3	3	26	1	0	0	0	0	1	0	0	0	5977	827	29	2	738	2	FLVCR1	1	213032530	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	9887753	213032530	36218091	36	5183											
HHIPL2	79802	broad.mit.edu	37	chr1	222721362	222721362	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaatgcagaccaccacacaGattaggagtggacgttctca	13	7	10	11	1	1	2	1	0	1	2	2	4	1	4	2	2	1	3	2	2	2	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:222721362G>C	uc001hnh.1	-	1	83	c.25C>G	c.(25-27)CTG>GTG	p.L9V		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	9					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CCACCACACAGATTAGGAGTG	0.547													23	47					0	0	0	0	C	222721362	C	C	222721362	3	2	26	1	0	0	0	0	1	0	0	0	7133	933	33	2	2185	2	HHIPL2	1	222721362	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	9688832	222721362	26529259	37	5184											
PARP1	142	broad.mit.edu	37	chr1	226567800	226567800	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacgtcctggaggaagtcctCagacacaactcggatgttgg	10	8	13	10	2	1	1	1	0	0	1	4	5	3	4	2	4	1	1	2	4	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:226567800C>G	uc001hqd.3	-	10	1537	c.1366G>C	c.(1366-1368)GAG>CAG	p.E456Q		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	456	Automodification domain.|BRCT.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		AGGAAGTCCTCAGACACAACT	0.488								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					18	48					0	0	0	0	G	226567800	G	G	226567800	3	3	26	1	0	0	0	0	1	0	0	0	11508	835	29	2	1734	2	PARP1	1	226567800	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	3846438	226567800	22682821	38	5185											
WNT9A	7483	broad.mit.edu	37	chr1	228113207	228113207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgggaggatggtcaggggctCgctgcccgtcagcctgggca	5	6	18	12	3	2	0	2	0	0	0	3	2	2	2	2	6	2	3	2	6	0	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:228113207C>T	uc001hri.2	-	2	197	c.109G>A	c.(109-111)GAG>AAG	p.E37K		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	37					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				GTCAGGGGCTCGCTGCCCGTC	0.711													7	10					0	0	0	0	T	228113207	T	T	228113207	3	4	26	1	0	0	0	0	1	0	0	0	17466	893	31	1	1000	1	WNT9A	1	228113207	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1545407	228113207	21137414	39	5186											
C1orf96	126731	broad.mit.edu	37	chr1	229478177	229478177	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcggctcctggtagcgcttCatgtactcgctcttcacccc	4	11	9	17	4	3	0	2	0	1	0	5	0	4	0	3	2	2	5	3	2	2	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:229478177C>T	uc001htl.3	-	2	114	c.36G>A	c.(34-36)ATG>ATA	p.M12I	C1orf96_uc009xfc.2_RNA	NM_145257	NP_660300	Q6IQ19	CA096_HUMAN	hypothetical protein LOC126731	12						centrosome					0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.178)				GGTAGCGCTTCATGTACTCGC	0.726													10	32					0	0	0	0	T	229478177	T	T	229478177	3	4	26	1	0	0	0	0	1	0	0	0	2083	826	29	2	788	2	C1orf96	1	229478177	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1364970	229478177	19772444	40	5187											
LYST	1130	broad.mit.edu	37	chr1	235964315	235964327	+	Frame_Shift_Del	DEL	TTCCCCTTGAGTG	-	-																															caaatctcaggataaattatTtccccttgagtgaggttttc																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:235964315_235964327delTTCCCCTTGAGTG	uc001hxj.2	-	9	3958_3970	c.3783_3795delCACTCAAGGGGAA	c.(3781-3795)CTCACTCAAGGGGAAfs	p.L1261fs	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Frame_Shift_Del_p.L1261fs	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1261_1265					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GATAAATTATTTCCCCTTGAGTGAGGTTTTCGA	0.366									Chediak-Higashi_syndrome				---	---	---								-	235964327	-	-	235964315	7	5	26	1	0	1	0	1	0	0	0	0	9179	1838	64	0	7790	0	LYST	1	235964315	Frame_Shift_Del	DEL	TTCCCCTTGAGTG	TCGA-BB-4227-01A-01D-1870-08	6486138	235964315	13286306	41	5188											
OR14A16	284532	broad.mit.edu	37	chr1	247978846	247978846	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatccaagaaagatagattCttcaagaagaaatacacggg	19	7	9	6	1	2	6	1	0	1	6	3	6	3	6	1	1	1	0	1	1	7	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr1:247978846C>T	uc001idm.1	-	1	186	c.186G>A	c.(184-186)AAG>AAA	p.K62K		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAGATAGATTCTTCAAGAAGA	0.418													23	62					0	0	0	0	T	247978846	T	T	247978846	2	4	26	1	0	0	0	0	0	0	0	1	10999	912	32	2		2	OR14A16	1	247978846	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	12014531	247978846	1271775	42	5189											
LPIN1	23175	broad.mit.edu	37	chr2	11955216	11955216	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgttttatgtctttcaggaAtggatataaatttctctact	11	19	6	5	0	3	0	1	0	2	0	4	2	3	2	0	2	1	1	0	2	6	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:11955216A>G	uc010yjn.1	+	18	2418	c.2144A>G	c.(2143-2145)AAT>AGT	p.N715S	LPIN1_uc010yjm.1_Missense_Mutation_p.N800S|LPIN1_uc002rbt.2_Missense_Mutation_p.N715S|LPIN1_uc010yjo.1_Missense_Mutation_p.N216S	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	715	C-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		TCTTTCAGGAATGGATATAAA	0.488													18	36					0	0	0	0	G	11955216	G	G	11955216	3	3	26	1	0	0	0	0	1	0	0	0	8968	101	4	5	2206	5	LPIN1	2	11955216	Missense_Mutation	SNP	A	TCGA-BB-4227-01A-01D-1870-08		11955216	231244157	43	5190											
WDR35	57539	broad.mit.edu	37	chr2	20113939	20113939	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagtttaatgaaagcttttGaacaagtcccaaaggctctg	14	12	8	7	0	1	2	0	2	1	0	2	2	2	2	1	1	2	3	1	1	6	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:20113939G>A	uc002rdi.2	-	27	3362	c.3254C>T	c.(3253-3255)TCA>TTA	p.S1085L	WDR35_uc002rdj.2_Missense_Mutation_p.S1074L|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Intron	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	1085										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAAAGCTTTTGAACAAGTCCC	0.433													30	53					0	0	0	0	A	20113939	A	A	20113939	3	1	26	1	0	0	0	0	1	0	0	0	17357	1294	45	2	299	2	WDR35	2	20113939	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	8158723	20113939	223085434	44	5191											
APOB	338	broad.mit.edu	37	chr2	21232316	21232316	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccagatacactgcaactgtgGccttggtttcctctaaaaac	11	11	7	12	0	1	1	0	0	1	1	2	1	2	1	3	2	4	2	3	2	5	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:21232316G>T	uc002red.2	-	26	7552	c.7424C>A	c.(7423-7425)GCC>GAC	p.A2475D		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2475					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGCAACTGTGGCCTTGGTTTC	0.418													26	107					2.65835e-16	2.81923e-16	1	0	T	21232316	T	T	21232316	3	4	26	1	0	0	0	0	1	0	0	0	785	1203	42	4	6283	4	APOB	2	21232316	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1118377	21232316	221967057	45	5192											
NLRC4	58484	broad.mit.edu	37	chr2	32476577	32476577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtcaatatcttcaccaaggGgataaaagttcagaaaagat	17	10	8	6	0	4	2	3	0	1	2	4	3	4	3	1	2	0	1	1	2	7	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:32476577G>A	uc002roi.2	-	4	602	c.356C>T	c.(355-357)CCC>CTC	p.P119L	NLRC4_uc002roj.1_Missense_Mutation_p.P119L|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	119					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTCACCAAGGGGATAAAAGTT	0.433													27	40					0	0	0	0	A	32476577	A	A	32476577	3	1	26	1	0	0	0	0	1	0	0	0	10523	1232	43	4	2742	4	NLRC4	2	32476577	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	11244261	32476577	210722796	46	5193											
NLRC4	58484	broad.mit.edu	37	chr2	32476659	32476659	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caagtctccttctgatgtctGatgaaaaagacctattagag	13	12	8	8	0	3	5	0	3	3	2	4	5	3	5	2	0	0	0	2	0	5	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:32476659G>C	uc002roi.2	-	4	520	c.274C>G	c.(274-276)CAG>GAG	p.Q92E	NLRC4_uc002roj.1_Missense_Mutation_p.Q92E|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	92					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TCTGATGTCTGATGAAAAAGA	0.433													25	48					0	0	0	0	C	32476659	C	C	32476659	3	2	26	1	0	0	0	0	1	0	0	0	10523	1299	45	2	2824	2	NLRC4	2	32476659	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	82	32476659	210722714	47	5194											
TTC27	55622	broad.mit.edu	37	chr2	32983539	32983539	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcggaacaaggagtttcaaGagtgtgtagagtgcttcgaa	12	11	13	5	2	1	2	1	0	0	2	3	5	1	4	0	2	2	3	0	2	5	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:32983539G>C	uc002rom.2	+	13	1864	c.1633G>C	c.(1633-1635)GAG>CAG	p.E545Q	TTC27_uc010ymx.1_Missense_Mutation_p.E495Q|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	545	TPR 3.|HAT 1.						protein binding			central_nervous_system(1)	1						GGAGTTTCAAGAGTGTGTAGA	0.522													34	60					0	0	0	0	C	32983539	C	C	32983539	3	2	26	1	0	0	0	0	1	0	0	0	16763	943	33	2	1683	2	TTC27	2	32983539	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	506880	32983539	210215834	48	5195											
GALM	130589	broad.mit.edu	37	chr2	38893363	38893363	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgggaggagggacagtggaGaagttccagctgcagtcaga	11	6	17	7	1	1	2	1	0	0	2	3	6	2	5	1	4	2	3	1	4	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:38893363G>A	uc002rqy.2	+	1	312	c.60G>A	c.(58-60)GAG>GAA	p.E20E		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	20					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				GGACAGTGGAGAAGTTCCAGC	0.597													15	42					0	0	0	0	A	38893363	A	A	38893363	2	1	26	1	0	0	0	0	0	0	0	1	6240	933	33	2		2	GALM	2	38893363	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	5909824	38893363	204306010	49	5196											
FAM161A	84140	broad.mit.edu	37	chr2	62067353	62067353	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgctttatgtaccatttcGatatctgatttagatttcat	10	18	6	7	2	2	2	1	1	1	1	3	3	2	2	1	0	2	2	1	0	4	8			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:62067353G>A	uc010ypo.1	-	3	888	c.786C>T	c.(784-786)ATC>ATT	p.I262I	FAM161A_uc002sbm.3_Silent_p.I262I|FAM161A_uc002sbn.3_Silent_p.I72I|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Silent_p.I153I	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	262					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						GTACCATTTCGATATCTGATT	0.393													37	69					0	0	0	0	A	62067353	A	A	62067353	2	1	26	1	0	0	0	0	0	0	0	1	5500	1048	37	1		1	FAM161A	2	62067353	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	23173990	62067353	181132020	50	5197											
CD8B	926	broad.mit.edu	37	chr2	87085532	87085533	+	Frame_Shift_Ins	INS	-	T	T																															gctggaggactgagttgccaINStggagaactaggaaaagcca																								rs137953763	byFrequency	TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:87085532_87085533insT	uc002srz.2	-	2	100_101	c.50_51insA	c.(49-51)CATfs	p.H17fs	RMND5A_uc002srs.3_Intron|CD8B_uc002srw.2_Frame_Shift_Ins_p.H17fs|CD8B_uc002srx.2_Frame_Shift_Ins_p.H17fs|CD8B_uc002sry.2_Frame_Shift_Ins_p.H17fs|CD8B_uc010fgt.2_Frame_Shift_Ins_p.H17fs|CD8B_uc002ssa.2_Frame_Shift_Ins_p.H17fs|CD8B_uc010yto.1_Frame_Shift_Ins_p.H17fs	NM_004931	NP_004922	P10966	CD8B_HUMAN	CD8b antigen isoform 5 precursor	17					immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			upper_aerodigestive_tract(1)|skin(1)	2						CTGAGTTGCCATGGAGAACTAG	0.49													---	---	---								T	87085533	T	T	87085532	7	5	26	1	0	1	1	0	0	0	0	0	3060	214	8	0	875	0	CD8B	2	87085532	Frame_Shift_Ins	INS	-	TCGA-BB-4227-01A-01D-1870-08	25018179	87085532	156113841	51	5198											
TRIM43	129868	broad.mit.edu	37	chr2	96260159	96260159	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctcacaaacaccatcccatcGaagaggcagctgaggaacac	15	4	8	14	1	1	2	1	1	0	1	3	4	2	3	2	2	3	2	2	2	3	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:96260159G>C	uc002suv.2	+	2	524	c.388G>C	c.(388-390)GAA>CAA	p.E130Q		NM_138800	NP_620155	Q96BQ3	TRI43_HUMAN	tripartite motif-containing 43	130	Potential.					intracellular	zinc ion binding			ovary(1)	1						CCATCCCATCGAAGAGGCAGC	0.488													37	53					0	0	0	0	C	96260159	C	C	96260159	3	2	26	1	0	0	0	0	1	0	0	0	16585	1059	37	3	390	3	TRIM43	2	96260159	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	9174627	96260159	146939214	52	5199											
FAHD2B	151313	broad.mit.edu	37	chr2	97749505	97749505	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagccatcacaccaccttgTtgatgatgacacctagttct	10	11	8	12	0	2	3	1	3	1	0	2	4	2	4	4	1	1	2	4	1	1	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:97749505T>C	uc002sxm.2	-	8	1083	c.932A>G	c.(931-933)AAC>AGC	p.N311S		NM_199336	NP_955368	Q6P2I3	FAH2B_HUMAN	fumarylacetoacetate hydrolase domain containing	311							hydrolase activity|metal ion binding				0						CACCACCTTGTTGATGATGAC	0.567													38	88					0	0	0	0	C	97749505	C	C	97749505	3	2	26	1	0	0	0	0	1	0	0	0	5402	1725	60	5	16	5	FAHD2B	2	97749505	Missense_Mutation	SNP	T	TCGA-BB-4227-01A-01D-1870-08	1489346	97749505	145449868	53	5200											
TGFBRAP1	9392	broad.mit.edu	37	chr2	105912815	105912815	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccagttaattacaaacctGaaatttttcctttggaatgt	13	15	6	7	0	0	1	0	1	0	0	1	3	1	2	3	1	2	1	3	1	5	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:105912815G>A	uc002tcq.2	-	4	1120	c.1036C>T	c.(1036-1038)CAG>TAG	p.Q346*	TGFBRAP1_uc010fjc.2_Nonsense_Mutation_p.Q116*|TGFBRAP1_uc002tcr.3_Nonsense_Mutation_p.Q346*	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	346					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						TTACAAACCTGAAATTTTTCC	0.328													37	74					0	0	0	0	A	105912815	A	A	105912815	4	1	26	1	0	0	0	0	0	1	0	0	15890	1299	45	2	1582	2	TGFBRAP1	2	105912815	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	8163310	105912815	137286558	54	5201											
GCC2	9648	broad.mit.edu	37	chr2	109103017	109103017	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaaaatccacgagcacctGaaaacctctgcggaacagca	16	4	7	14	2	1	1	0	1	1	0	2	3	2	2	3	1	5	2	3	1	5	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:109103017G>A	uc002tec.2	+	16	3997	c.3843G>A	c.(3841-3843)CTG>CTA	p.L1281L	GCC2_uc002ted.2_Silent_p.L1180L	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1281	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						ACGAGCACCTGAAAACCTCTG	0.473													50	79					0	0	0	0	A	109103017	A	A	109103017	2	1	26	1	0	0	0	0	0	0	0	1	6321	1277	45	2		2	GCC2	2	109103017	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	3190202	109103017	134096356	55	5202											
IL1F8	27177	broad.mit.edu	37	chr2	113780314	113780314	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatctttgtccttcttcctGagatggtgatgttgaaagga	10	15	10	6	0	2	3	0	3	2	1	4	5	4	4	2	2	0	1	2	2	2	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:113780314G>C	uc002tiq.1	-	6	536	c.432C>G	c.(430-432)CTC>CTG	p.L144L		NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	144					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						CCTTCTTCCTGAGATGGTGAT	0.433													51	68					0	0	0	0	C	113780314	C	C	113780314	2	2	26	1	0	0	0	0	0	0	0	1	7695	1277	45	2		2	IL1F8	2	113780314	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	4677297	113780314	129419059	56	5203											
DBI	1622	broad.mit.edu	37	chr2	120128369	120128369	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaagtgggatgcctggaatGagctgaaaggtaattgttct	11	11	13	6	0	1	2	0	2	1	0	1	4	1	4	2	3	2	3	2	3	4	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:120128369G>A	uc002tlv.2	+	3	305	c.181G>A	c.(181-183)GAG>AAG	p.E61K	DBI_uc010yyh.1_Missense_Mutation_p.E78K|DBI_uc010yyi.1_Missense_Mutation_p.E78K|DBI_uc010yyj.1_RNA|DBI_uc010yyk.1_Missense_Mutation_p.E103K|DBI_uc010yyl.1_Missense_Mutation_p.E78K|DBI_uc010yym.1_Missense_Mutation_p.E71K|DBI_uc010yyn.1_Missense_Mutation_p.E78K|DBI_uc002tlw.2_Missense_Mutation_p.E78K|DBI_uc010yyo.1_RNA|DBI_uc002tlx.2_Missense_Mutation_p.E62K	NM_001079862	NP_001073331	P07108	ACBP_HUMAN	diazepam binding inhibitor isoform 3	61	ACB.				transport		benzodiazepine receptor binding|fatty-acyl-CoA binding				0						TGCCTGGAATGAGCTGAAAGG	0.418													14	27					0	0	0	0	A	120128369	A	A	120128369	3	1	26	1	0	0	0	0	1	0	0	0	4268	1291	45	2	497	2	DBI	2	120128369	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	6348055	120128369	123071004	57	5204											
ERCC3	2071	broad.mit.edu	37	chr2	128038127	128038127	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttaaatccacaattttgtCatcttcgcggacgagggtcg	10	13	9	9	4	2	0	1	0	1	0	5	2	3	1	1	2	0	0	1	2	3	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:128038127C>G	uc002toh.1	-	9	1518	c.1423G>C	c.(1423-1425)GAC>CAC	p.D475H	ERCC3_uc002toe.1_Missense_Mutation_p.D230H|ERCC3_uc002tof.1_Missense_Mutation_p.D411H|ERCC3_uc002tog.1_Missense_Mutation_p.D411H	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	475	Helicase ATP-binding.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		ACAATTTTGTCATCTTCGCGG	0.507			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				17	45					0	0	0	0	G	128038127	G	G	128038127	3	3	26	1	0	0	0	0	1	0	0	0	5238	826	29	2	953	2	ERCC3	2	128038127	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	7909758	128038127	115161246	58	5205											
GPR39	2863	broad.mit.edu	37	chr2	133402856	133402856	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccgctcctgtacacggtgTcctcgcagcagtttcggcgg	5	9	12	15	5	0	0	0	0	0	0	4	0	2	0	3	3	2	5	3	3	1	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:133402856T>G	uc002ttl.2	+	2	1508	c.1039T>G	c.(1039-1041)TCC>GCC	p.S347A	LYPD1_uc002ttm.3_3'UTR|LYPD1_uc002ttn.2_3'UTR|LYPD1_uc002tto.2_3'UTR	NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	347	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						GTACACGGTGTCCTCGCAGCA	0.622													23	72					0	0	0	0	G	133402856	G	G	133402856	3	3	26	1	0	0	0	0	1	0	0	0	6731	1667	58	5	1045	5	GPR39	2	133402856	Missense_Mutation	SNP	T	TCGA-BB-4227-01A-01D-1870-08	5364729	133402856	109796517	59	5206											
YSK4	80122	broad.mit.edu	37	chr2	135744048	135744048	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagacaggagggaattcattCtgtttcatggactgctcagg	10	11	13	7	0	4	1	3	0	1	1	4	5	4	4	0	4	1	2	0	4	1	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:135744048C>G	uc002tue.1	-	7	2425	c.2394G>C	c.(2392-2394)CAG>CAC	p.Q798H	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.Q685H|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.Q526H|YSK4_uc002tui.3_Missense_Mutation_p.Q815H	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	798							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GGAATTCATTCTGTTTCATGG	0.393													21	70					0	0	0	0	G	135744048	G	G	135744048	3	3	26	1	0	0	0	0	1	0	0	0	17563	912	32	2	1608	2	YSK4	2	135744048	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	2341192	135744048	107455325	60	5207											
KYNU	8942	broad.mit.edu	37	chr2	143797996	143797996	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgattgtttctcattccacaGatctttaagcaagcgacaat	12	14	6	9	1	2	2	1	1	2	1	4	3	3	2	1	0	2	2	1	0	3	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:143797996G>A	uc002tvl.2	+	13	1172	c.1042_splice	c.e13-1	p.I348_splice	KYNU_uc010fnm.2_Splice_Site_p.I348_splice	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a						anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TCATTCCACAGATCTTTAAGC	0.333													21	50					0	0	0	0	A	143797996	A	A	143797996	5	1	26	1	0	0	0	0	0	0	1	0	8627	956	33	2	1113	2	KYNU	2	143797996	Splice_Site	SNP	G	TCGA-BB-4227-01A-01D-1870-08	8053948	143797996	99401377	61	5208											
ABCB11	8647	broad.mit.edu	37	chr2	169788945	169788945	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttgtcggtccagcagttgaAaaaagcgtgcagctgatatt	11	11	12	7	2	0	2	0	2	0	0	2	2	1	2	1	1	4	5	1	1	4	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:169788945A>G	uc002ueo.1	-	24	3281	c.3155T>C	c.(3154-3156)TTT>TCT	p.F1052S	ABCB11_uc010zda.1_Missense_Mutation_p.F494S|ABCB11_uc010zdb.1_Missense_Mutation_p.F528S	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1052	Cytoplasmic (Potential).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CAGCAGTTGAAAAAAGCGTGC	0.373													8	10					0	0	0	0	G	169788945	G	G	169788945	3	3	26	1	0	0	0	0	1	0	0	0	42	14	1	5	830	5	ABCB11	2	169788945	Missense_Mutation	SNP	A	TCGA-BB-4227-01A-01D-1870-08	25990949	169788945	73410428	62	5209											
ABCB11	8647	broad.mit.edu	37	chr2	169792772	169792772	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctccagggcctgcttatctcGagaggcaaatcctgtcaaca	10	9	9	13	1	2	1	1	0	1	1	5	2	4	1	3	2	2	2	3	2	3	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:169792772G>C	uc002ueo.1	-	22	2908	c.2782C>G	c.(2782-2784)CGA>GGA	p.R928G	ABCB11_uc010zda.1_Missense_Mutation_p.R370G|ABCB11_uc010zdb.1_Missense_Mutation_p.R404G	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	928	Cytoplasmic (Potential).|ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TGCTTATCTCGAGAGGCAAAT	0.488													18	29					0	0	0	0	C	169792772	C	C	169792772	3	2	26	1	0	0	0	0	1	0	0	0	42	1066	37	3	1211	3	ABCB11	2	169792772	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	3827	169792772	73406601	63	5210											
PDK1	5163	broad.mit.edu	37	chr2	173429336	173429336	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctttggggtggatcctgtCaccagccagaatgttcagta	9	11	12	9	0	2	1	2	0	0	1	3	2	3	2	3	3	2	3	3	3	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:173429336C>G	uc002uhr.2	+	4	616	c.516C>G	c.(514-516)GTC>GTG	p.V172V	PDK1_uc010zdz.1_Silent_p.V17V|PDK1_uc010zea.1_RNA|PDK1_uc002uhq.1_Silent_p.V192V|PDK1_uc002uhs.2_Silent_p.V172V|PDK1_uc010zeb.1_Silent_p.V192V	NM_002610	NP_002601	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase 1 precursor	172	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(3)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.12)			TGGATCCTGTCACCAGCCAGA	0.443									Autosomal_Dominant_Polycystic_Kidney_Disease				26	55					0	0	0	0	G	173429336	G	G	173429336	2	3	26	1	0	0	0	0	0	0	0	1	11729	813	29	2		2	PDK1	2	173429336	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	3636564	173429336	69770037	64	5211											
TTC30A	92104	broad.mit.edu	37	chr2	178482268	178482268	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgagtctccgaagctgctCagtcagcatccctgctagcc	7	9	11	14	1	3	1	2	1	1	0	5	2	4	1	3	1	5	4	3	1	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:178482268C>G	uc002ulo.2	-	1	1427	c.1162G>C	c.(1162-1164)GAG>CAG	p.E388Q		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	388					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			CGAAGCTGCTCAGTCAGCATC	0.463													99	122					0	0	0	0	G	178482268	G	G	178482268	3	3	26	1	0	0	0	0	1	0	0	0	16766	835	29	2	839	2	TTC30A	2	178482268	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	5052932	178482268	64717105	65	5212											
TTN	7273	broad.mit.edu	37	chr2	179392320	179392320	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgcttgcaaatttcatctCagtcatgctgctagcactgc	9	13	7	12	0	3	0	3	0	1	0	4	0	3	0	0	0	6	5	0	0	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:179392320C>T	uc010zfg.1	-	311	100053	c.99829G>A	c.(99829-99831)GAG>AAG	p.E33277K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E26972K|TTN_uc010zfi.1_Missense_Mutation_p.E26905K|TTN_uc010zfj.1_Missense_Mutation_p.E26780K|TTN_uc002umq.2_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	34204							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTTCATCTCAGTCATGCTG	0.478													36	35					0	0	0	0	T	179392320	T	T	179392320	3	4	26	1	0	0	0	0	1	0	0	0	16803	835	29	2	450	2	TTN	2	179392320	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	910052	179392320	63807053	66	5213											
TTN	7273	broad.mit.edu	37	chr2	179458787	179458787	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgtttggccttgatcttctCtaaagcaagtgttgctggtg	7	15	11	8	1	2	1	0	1	2	0	3	1	2	1	1	2	2	4	1	2	3	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:179458787C>G	uc010zfg.1	-	246	50853	c.50629G>C	c.(50629-50631)GAG>CAG	p.E16877Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E10572Q|TTN_uc010zfi.1_Missense_Mutation_p.E10505Q|TTN_uc010zfj.1_Missense_Mutation_p.E10380Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17804							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGATCTTCTCTAAAGCAAGT	0.438													60	112					0	0	0	0	G	179458787	G	G	179458787	3	3	26	1	0	0	0	0	1	0	0	0	16803	922	32	2	49910	2	TTN	2	179458787	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	66467	179458787	63740586	67	5214											
MFSD6	54842	broad.mit.edu	37	chr2	191362379	191362379	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgacctttgtctatgcactCtaccaaattaaagagatgat	13	13	7	8	0	2	3	0	2	2	1	2	4	2	3	2	0	2	1	2	0	5	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:191362379C>G	uc002urz.2	+	7	2430	c.2106C>G	c.(2104-2106)CTC>CTG	p.L702L	MFSD6_uc010zge.1_Silent_p.L164L	NM_017694	NP_060164	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing	702					transmembrane transport	integral to membrane				ovary(2)	2						TCTATGCACTCTACCAAATTA	0.463													33	26					0	0	0	0	G	191362379	G	G	191362379	2	3	26	1	0	0	0	0	0	0	0	1	9588	900	32	2		2	MFSD6	2	191362379	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	11903592	191362379	51836994	68	5215											
RNPEPL1	57140	broad.mit.edu	37	chr2	241517130	241517131	+	Frame_Shift_Del	DEL	AG	-	-																															ggctgcaccccaacctgcgcAgagccatccagcagatcctg																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr2:241517130_241517131delAG	uc002vzi.2	+	11	1899_1900	c.1306_1307delAG	c.(1306-1308)AGAfs	p.R436fs	RNPEPL1_uc010fzf.2_Frame_Shift_Del_p.R342fs|RNPEPL1_uc002vzj.2_Frame_Shift_Del_p.R84fs	NM_018226	NP_060696	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like	436					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		CAACCTGCGCAGAGCCATCCAG	0.663													---	---	---								-	241517131	-	-	241517130	7	5	26	1	0	1	0	1	0	0	0	0	13575	180	7	0	1340	0	RNPEPL1	2	241517130	Frame_Shift_Del	DEL	AG	TCGA-BB-4227-01A-01D-1870-08	50154751	241517130	1682243	69	5216											
TMEM40	55287	broad.mit.edu	37	chr3	12777058	12777058	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agactttaaaagttacctgtCagcctaaacttctggaagag	14	11	8	8	0	2	2	1	0	1	2	2	3	2	3	2	1	3	1	2	1	6	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:12777058C>A	uc003bxg.1	-	11	805	c.678G>T	c.(676-678)CTG>CTT	p.L226L	TMEM40_uc003bxh.1_Silent_p.L196L|TMEM40_uc003bxi.1_Silent_p.L150L|TMEM40_uc011auv.1_Silent_p.L242L	NM_018306	NP_060776	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	226						integral to membrane					0						AGTTACCTGTCAGCCTAAACT	0.403													7	69					2.74318e-10	2.85167e-10	1	0	A	12777058	A	A	12777058	2	1	26	1	0	0	0	0	0	0	0	1	16229	813	29	2		2	TMEM40	3	12777058	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08		12777058	185245372	70	5217											
FBLN2	2199	broad.mit.edu	37	chr3	13670672	13670672	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccccccacagacgtgaatGagtgtgagacaggtgtgcac	11	6	12	12	1	0	4	0	3	0	2	0	5	0	4	3	1	1	1	3	1	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:13670672G>T	uc011avb.1	+	12	2706	c.2581G>T	c.(2581-2583)GAG>TAG	p.E861*	FBLN2_uc011auz.1_Nonsense_Mutation_p.E887*|FBLN2_uc011ava.1_Nonsense_Mutation_p.E908*|FBLN2_uc011avc.1_Nonsense_Mutation_p.E908*	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	861	EGF-like 6; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGACGTGAATGAGTGTGAGAC	0.667													16	9					1.33834e-09	1.38345e-09	1	0	T	13670672	T	T	13670672	4	4	26	1	0	0	0	0	0	1	0	0	5731	1291	45	2	1458	2	FBLN2	3	13670672	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	893614	13670672	184351758	71	5218											
PRSS50	29122	broad.mit.edu	37	chr3	46759219	46759219	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggactcacctgcagacctCagcaacagaagcagcagcag	14	3	11	13	0	2	2	2	0	0	2	2	3	2	3	2	1	6	5	2	1	2	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:46759219C>G	uc003cqe.1	-	1	155	c.96G>C	c.(94-96)CTG>CTC	p.L32L	PRSS50_uc003cqf.1_Intron	NM_013270	NP_037402	Q9UI38	TSP50_HUMAN	testes-specific protease 50 precursor	32					proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity				0						CTGCAGACCTCAGCAACAGAA	0.721													6	2					0	0	0	0	G	46759219	G	G	46759219	2	3	26	1	0	0	0	0	0	0	0	1	12693	813	29	2		2	PRSS50	3	46759219	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	33088547	46759219	151263211	72	5219											
SLMAP	7871	broad.mit.edu	37	chr3	57743444	57743444	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtttcaggagcgtcatgtCtacctggacgagcccatcaa	9	9	10	13	3	4	0	3	0	1	0	4	3	4	2	3	2	3	1	3	2	2	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:57743444C>T	uc003dje.1	+	1	271	c.66C>T	c.(64-66)GTC>GTT	p.V22V	SLMAP_uc003djc.1_Silent_p.V22V|SLMAP_uc003djd.1_Silent_p.V22V|SLMAP_uc003djf.1_Silent_p.V22V	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	22	Necessary for targeting to centrosomes (By similarity).|Cytoplasmic (Potential).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		AGCGTCATGTCTACCTGGACG	0.572													26	9					0	0	0	0	T	57743444	T	T	57743444	2	4	26	1	0	0	0	0	0	0	0	1	14813	900	32	2		2	SLMAP	3	57743444	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	10984225	57743444	140278986	73	5220											
LRIG1	26018	broad.mit.edu	37	chr3	66432706	66432706	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaggccttaccattgctctCaatgtgcccattggcctgag	7	12	10	12	0	1	2	1	2	1	0	2	2	1	2	4	2	3	1	4	2	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:66432706C>G	uc003dmx.2	-	16	2622	c.2608G>C	c.(2608-2610)GAG>CAG	p.E870Q	SLC25A26_uc011bft.1_Intron|LRIG1_uc011bfu.1_Missense_Mutation_p.E490Q|LRIG1_uc003dmw.2_Missense_Mutation_p.E536Q|LRIG1_uc010hnz.2_Missense_Mutation_p.E586Q|LRIG1_uc010hoa.2_Missense_Mutation_p.E847Q	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	870	Cytoplasmic (Potential).					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CCATTGCTCTCAATGTGCCCA	0.567													56	38					0	0	0	0	G	66432706	G	G	66432706	3	3	26	1	0	0	0	0	1	0	0	0	8994	835	29	2	689	2	LRIG1	3	66432706	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	8689262	66432706	131589724	74	5221											
HTR1F	3355	broad.mit.edu	37	chr3	88040493	88040493	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcccactggcattgattttGatcctttactacaaaatata	13	15	4	9	0	0	2	0	2	0	0	2	2	2	2	2	1	2	1	2	1	6	8			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:88040493G>C	uc003dqr.2	+	2	752	c.594G>C	c.(592-594)TTG>TTC	p.L198F		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	198	Helical; Name=5; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	CATTGATTTTGATCCTTTACT	0.408													51	16					0	0	0	0	C	88040493	C	C	88040493	3	2	26	1	0	0	0	0	1	0	0	0	7479	1281	45	2	596	2	HTR1F	3	88040493	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	21607787	88040493	109981937	75	5222											
DCBLD2	131566	broad.mit.edu	37	chr3	98518387	98518387	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcagctgtcagtcctggaGagaagtgtattgtaagttcc	10	11	13	7	0	1	1	1	0	0	1	3	4	3	2	2	1	2	5	2	1	3	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:98518387G>A	uc003dtd.2	-	16	2520	c.2157C>T	c.(2155-2157)CTC>CTT	p.L719L	DCBLD2_uc003dte.2_Silent_p.L733L	NM_080927	NP_563615	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	719	Cytoplasmic (Potential).				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3						CAGTCCTGGAGAGAAGTGTAT	0.572													67	253					0	0	0	0	A	98518387	A	A	98518387	2	1	26	1	0	0	0	0	0	0	0	1	4298	929	33	2		2	DCBLD2	3	98518387	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	10477894	98518387	99504043	76	5223											
HSPBAP1	79663	broad.mit.edu	37	chr3	122474119	122474119	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctattacctgtcctgggctCagtgtaaccgcatgtctttg	6	14	9	12	1	2	0	1	0	1	0	3	0	3	0	4	1	2	3	4	1	3	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:122474119C>G	uc003efu.1	-	5	852	c.729G>C	c.(727-729)CTG>CTC	p.L243L	HSPBAP1_uc003efv.1_3'UTR	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	243	JmjC.					cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)		GTCCTGGGCTCAGTGTAACCG	0.448													19	55					0	0	0	0	G	122474119	G	G	122474119	2	3	26	1	0	0	0	0	0	0	0	1	7464	813	29	2		2	HSPBAP1	3	122474119	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	23955732	122474119	75548311	77	5224											
UROC1	131669	broad.mit.edu	37	chr3	126219702	126219702	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccccgtcgtgtccaattcGtggaccaggcgctccctggg	4	9	12	16	4	0	0	0	0	0	0	5	1	3	1	5	3	0	1	5	3	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:126219702G>A	uc003eiz.1	-	11	1013	c.981C>T	c.(979-981)CAC>CAT	p.H327H	UROC1_uc010hsi.1_Silent_p.H387H	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	327					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		TGTCCAATTCGTGGACCAGGC	0.637													23	40					0	0	0	0	A	126219702	A	A	126219702	2	1	26	1	0	0	0	0	0	0	0	1	17096	1136	40	1		1	UROC1	3	126219702	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	3745583	126219702	71802728	78	5225											
CHST13	166012	broad.mit.edu	37	chr3	126260987	126260987	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctacagcgccgccttccagAggcgctacggtgcacgcatc	7	6	11	17	5	0	1	0	0	0	1	2	1	1	1	4	2	4	3	4	2	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:126260987A>T	uc003eja.2	+	3	592	c.592A>T	c.(592-594)AGG>TGG	p.R198W		NM_152889	NP_690849	Q8NET6	CHSTD_HUMAN	carbohydrate sulfotransferase 13	198	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.151)		CGCCTTCCAGAGGCGCTACGG	0.547													9	11					0	0	0	0	T	126260987	T	T	126260987	3	4	26	1	0	0	0	0	1	0	0	0	3416	295	11	5	602	5	CHST13	3	126260987	Missense_Mutation	SNP	A	TCGA-BB-4227-01A-01D-1870-08	41285	126260987	71761443	79	5226											
ACAD11	84129	broad.mit.edu	37	chr3	132345633	132345633	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacaactgtccagtagtatCaatctgtggtagtacagtac	14	11	8	8	0	2	0	1	0	1	0	3	0	3	0	1	1	4	5	1	1	8	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:132345633C>G	uc003eov.3	-	9	1479	c.1099G>C	c.(1099-1101)GAT>CAT	p.D367H	ACAD11_uc011blr.1_5'UTR|ACAD11_uc003eoy.2_Missense_Mutation_p.D367H	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	367						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						CCAGTAGTATCAATCTGTGGT	0.338													19	55					0	0	0	0	G	132345633	G	G	132345633	3	3	26	1	0	0	0	0	1	0	0	0	109	826	29	2	1291	2	ACAD11	3	132345633	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	6084646	132345633	65676797	80	5227											
ZBTB38	253461	broad.mit.edu	37	chr3	141161524	141161524	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacagttccacagtcgttgtCaagagacaggaaacagtcac	14	8	9	10	1	2	1	2	0	0	1	4	3	3	2	1	1	2	2	1	1	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:141161524C>G	uc003etw.2	+	8	1276	c.294C>G	c.(292-294)GTC>GTG	p.V98V	ZBTB38_uc010hun.2_Silent_p.V95V|ZBTB38_uc010huo.2_Silent_p.V98V|ZBTB38_uc003ety.2_Silent_p.V98V|ZBTB38_uc010hup.2_Silent_p.V99V	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	98	BTB.				positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CAGTCGTTGTCAAGAGACAGG	0.438													8	64					0	0	0	0	G	141161524	G	G	141161524	2	3	26	1	0	0	0	0	0	0	0	1	17606	813	29	2		2	ZBTB38	3	141161524	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	8815891	141161524	56860906	81	5228											
MED12L	116931	broad.mit.edu	37	chr3	151072985	151072985	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagactgtgttcactaaactCcagctcctttcatattttga	10	15	6	10	0	2	2	2	1	0	1	4	3	4	2	2	0	2	2	2	0	3	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:151072985C>G	uc003eyp.2	+	16	2408	c.2370C>G	c.(2368-2370)CTC>CTG	p.L790L	MED12L_uc011bnz.1_Silent_p.L650L|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_5'Flank	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	790					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCACTAAACTCCAGCTCCTTT	0.358													32	63					0	0	0	0	G	151072985	G	G	151072985	2	3	26	1	0	0	0	0	0	0	0	1	9482	842	30	2		2	MED12L	3	151072985	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	9911461	151072985	46949445	82	5229											
MED12L	116931	broad.mit.edu	37	chr3	151078367	151078367	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgtgtcatgtagccacctCagaagtaaatttggagacct	12	12	9	8	0	2	2	2	0	0	2	2	3	2	2	3	1	1	2	3	1	5	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:151078367C>T	uc003eyp.2	+	19	2864	c.2826C>T	c.(2824-2826)CTC>CTT	p.L942L	MED12L_uc011bnz.1_Silent_p.L802L|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Silent_p.L106L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	942					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTAGCCACCTCAGAAGTAAAT	0.428													68	173					0	0	0	0	T	151078367	T	T	151078367	2	4	26	1	0	0	0	0	0	0	0	1	9482	813	29	2		2	MED12L	3	151078367	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	5382	151078367	46944063	83	5230											
IGSF10	285313	broad.mit.edu	37	chr3	151155107	151155107	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcaatatagccaactttattCctagctgcacagcgatattt	12	14	5	10	1	1	0	1	0	0	0	2	1	2	0	2	0	5	2	2	0	7	8			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:151155107C>G	uc011bod.1	-	6	7242	c.7242G>C	c.(7240-7242)AGG>AGC	p.R2414S	IGSF10_uc011bob.1_Missense_Mutation_p.R441S|IGSF10_uc011boc.1_Missense_Mutation_p.R393S	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2414	Ig-like C2-type 10.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAACTTTATTCCTAGCTGCAC	0.393													62	131					0	0	0	0	G	151155107	G	G	151155107	3	3	26	1	0	0	0	0	1	0	0	0	7636	854	30	2	633	2	IGSF10	3	151155107	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	76740	151155107	46867323	84	5231											
IGSF10	285313	broad.mit.edu	37	chr3	151155347	151155347	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctaaatgtcggtcttctCagcatttccagtacttctaa	9	17	5	10	1	4	0	1	0	4	0	7	0	5	0	1	1	2	2	1	1	4	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:151155347C>G	uc011bod.1	-	6	7002	c.7002G>C	c.(7000-7002)CTG>CTC	p.L2334L	IGSF10_uc011bob.1_Silent_p.L361L|IGSF10_uc011boc.1_Silent_p.L313L	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2334					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCGGTCTTCTCAGCATTTCCA	0.448													67	178					0	0	0	0	G	151155347	G	G	151155347	2	3	26	1	0	0	0	0	0	0	0	1	7636	813	29	2		2	IGSF10	3	151155347	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	240	151155347	46867083	85	5232											
BCHE	590	broad.mit.edu	37	chr3	165548470	165548470	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttagatataaacagtcttCactgaggtcagtgtttgggt	11	15	10	5	0	3	2	2	1	1	1	3	2	3	2	0	2	1	1	0	2	4	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:165548470C>T	uc003fem.3	-	2	512	c.352G>A	c.(352-354)GAA>AAA	p.E118K	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	118					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAACAGTCTTCACTGAGGTCA	0.388													23	64					0	0	0	0	T	165548470	T	T	165548470	3	4	26	1	0	0	0	0	1	0	0	0	1360	835	29	2	1468	2	BCHE	3	165548470	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	14393123	165548470	32473960	86	5233											
FNDC3B	64778	broad.mit.edu	37	chr3	172070742	172070742	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttctgcgtgccttgtactGaactgggaagagccgtgcaa	8	10	12	11	2	1	2	0	1	1	1	1	3	1	3	3	1	6	2	3	1	4	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:172070742G>A	uc003fhy.2	+	22	2836	c.2664G>A	c.(2662-2664)CTG>CTA	p.L888L	FNDC3B_uc003fhz.3_Silent_p.L888L	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	888	Fibronectin type-III 7.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GCCTTGTACTGAACTGGGAAG	0.542													31	95					0	0	0	0	A	172070742	A	A	172070742	2	1	26	1	0	0	0	0	0	0	0	1	6002	1277	45	2		2	FNDC3B	3	172070742	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	6522272	172070742	25951688	87	5234											
YEATS2	55689	broad.mit.edu	37	chr3	183493896	183493896	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttacacatcttacatcctCaagcaaactccccaggtctg	12	10	4	15	0	3	0	1	0	2	0	5	0	5	0	3	1	4	1	3	1	4	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:183493896C>T	uc003fly.2	+	18	2757	c.2562C>T	c.(2560-2562)CTC>CTT	p.L854L	YEATS2_uc003flz.2_5'UTR	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	854					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CTTACATCCTCAAGCAAACTC	0.318													11	33					0	0	0	0	T	183493896	T	T	183493896	2	4	26	1	0	0	0	0	0	0	0	1	17540	813	29	2		2	YEATS2	3	183493896	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	11423154	183493896	14528534	88	5235											
EPHB3	2049	broad.mit.edu	37	chr3	184295229	184295229	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcccaacggagtcatcctgGactacgagatgaagtacttt	11	9	11	10	2	1	2	1	1	0	1	2	5	2	4	2	3	3	1	2	3	4	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:184295229G>C	uc003foz.2	+	6	1890	c.1453G>C	c.(1453-1455)GAC>CAC	p.D485H		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	485	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			AGTCATCCTGGACTACGAGAT	0.602													3	130					0	0	0	0	C	184295229	C	C	184295229	3	2	26	1	0	0	0	0	1	0	0	0	5200	1174	41	2	1475	2	EPHB3	3	184295229	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	801333	184295229	13727201	89	5236											
EPHB3	2049	broad.mit.edu	37	chr3	184298534	184298534	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagggcgggaagatccccatCcgctggactgccccagaggc	8	4	14	15	2	0	2	0	0	0	2	2	4	2	4	5	4	1	1	5	4	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:184298534C>T	uc003foz.2	+	13	2843	c.2406C>T	c.(2404-2406)ATC>ATT	p.I802I		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	802	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			AGATCCCCATCCGCTGGACTG	0.642													15	76					0	0	0	0	T	184298534	T	T	184298534	2	4	26	1	0	0	0	0	0	0	0	1	5200	845	30	2		2	EPHB3	3	184298534	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	3305	184298534	13723896	90	5237											
EPHB3	2049	broad.mit.edu	37	chr3	184298946	184298946	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaggtcattgccagcgctCagtctgggttagtacctctg	7	12	11	11	1	5	0	3	0	2	0	5	0	5	0	2	2	3	3	2	2	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:184298946C>T	uc003foz.2	+	14	3162	c.2725C>T	c.(2725-2727)CAG>TAG	p.Q909*		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	909	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TGCCAGCGCTCAGTCTGGGTT	0.572													48	127					0	0	0	0	T	184298946	T	T	184298946	4	4	26	1	0	0	0	0	0	1	0	0	5200	827	29	2	2779	2	EPHB3	3	184298946	Nonsense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	412	184298946	13723484	91	5238											
TMEM41A	90407	broad.mit.edu	37	chr3	185209541	185209541	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagatgaaattatatgggatCaaacctggaagaagaaaagg	19	7	11	4	0	1	4	1	1	0	3	1	6	1	6	1	3	1	0	1	3	8	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:185209541C>G	uc003fpj.2	-	5	675	c.579G>C	c.(577-579)TTG>TTC	p.L193F	TMEM41A_uc003fpk.2_Nonstop_Mutation_p.*93S	NM_080652	NP_542383	Q96HV5	TM41A_HUMAN	transmembrane protein 41A precursor	193	Helical; (Potential).					integral to membrane					0	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TATATGGGATCAAACCTGGAA	0.423													21	52					0	0	0	0	G	185209541	G	G	185209541	3	3	26	1	0	0	0	0	1	0	0	0	16230	825	29	2	219	2	TMEM41A	3	185209541	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	910595	185209541	12812889	92	5239											
PPP1R2	5504	broad.mit.edu	37	chr3	195243706	195243706	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatctcgtctatgaacttcgTaatttgttttgctgttggtc	7	19	8	7	2	2	1	0	1	2	0	5	1	2	1	0	1	2	4	0	1	4	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:195243706T>A	uc003fup.2	-	6	982	c.606A>T	c.(604-606)TTA>TTT	p.L202F		NM_006241	NP_006232	P41236	IPP2_HUMAN	protein phosphatase 1, regulatory subunit 2	202					glycogen metabolic process|regulation of phosphoprotein phosphatase activity|regulation of signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			urinary_tract(1)	1	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)		Epithelial(36;2.64e-22)|all cancers(36;2.69e-20)|OV - Ovarian serous cystadenocarcinoma(49;3.52e-19)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;9.55e-05)		ATGAACTTCGTAATTTGTTTT	0.358													29	27					0	0	0	0	A	195243706	A	A	195243706	3	1	26	1	0	0	0	0	1	0	0	0	12430	1635	57	5	15	5	PPP1R2	3	195243706	Missense_Mutation	SNP	T	TCGA-BB-4227-01A-01D-1870-08	10034165	195243706	2778724	93	5240											
PAK2	5062	broad.mit.edu	37	chr3	196554193	196554193	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaaaggggttcagccaaaGaattattacaggtaaattta	19	10	8	4	0	1	1	1	0	0	1	1	1	1	1	1	3	2	2	1	3	10	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr3:196554193G>C	uc003fwy.3	+	14	1799	c.1477G>C	c.(1477-1479)GAA>CAA	p.E493Q		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	493	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		TTCAGCCAAAGAATTATTACA	0.358													41	82					0	0	0	0	C	196554193	C	C	196554193	3	2	26	1	0	0	0	0	1	0	0	0	11455	943	33	2	1527	2	PAK2	3	196554193	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1310487	196554193	1468237	94	5241											
SLC34A2	10568	broad.mit.edu	37	chr4	25671434	25671434	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagatcttctgaaagtcatCactaagcccttcacaaagct	13	10	5	13	0	5	2	3	1	2	1	5	2	5	2	2	0	2	1	2	0	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:25671434C>T	uc003grr.2	+	7	882	c.801C>T	c.(799-801)ATC>ATT	p.I267I	SLC34A2_uc003grs.2_Silent_p.I266I|SLC34A2_uc010iev.2_Silent_p.I266I	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	267	Extracellular (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				TGAAAGTCATCACTAAGCCCT	0.483													74	41					0	0	0	0	T	25671434	T	T	25671434	2	4	26	1	0	0	0	0	0	0	0	1	14632	816	29	2		2	SLC34A2	4	25671434	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08		25671434	165482842	95	5242											
ARAP2	116984	broad.mit.edu	37	chr4	36130348	36130348	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatcaccattcttttgataGatatatttgcatcctaaacc	12	15	5	9	0	2	2	1	1	1	1	3	3	3	3	3	1	2	1	3	1	5	8			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:36130348G>C	uc003gsq.1	-	21	3785	c.3447C>G	c.(3445-3447)ATC>ATG	p.I1149M		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1149	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TCTTTTGATAGATATATTTGC	0.294													25	44					0	0	0	0	C	36130348	C	C	36130348	3	2	26	1	0	0	0	0	1	0	0	0	839	932	33	2	1719	2	ARAP2	4	36130348	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	10458914	36130348	155023928	96	5243											
PDS5A	23244	broad.mit.edu	37	chr4	39929692	39929692	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttattggggttcctgaggaaGaattcagatgcaagatgcaa	13	11	12	5	0	1	4	1	1	0	3	2	5	2	5	1	3	2	3	1	3	5	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:39929692G>A	uc003guv.3	-	3	771	c.231C>T	c.(229-231)TTC>TTT	p.F77F	PDS5A_uc010ifo.2_Silent_p.F37F|PDS5A_uc003guw.3_Silent_p.F77F	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	77					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						TCCTGAGGAAGAATTCAGATG	0.423													35	33					0	0	0	0	A	39929692	A	A	39929692	2	1	26	1	0	0	0	0	0	0	0	1	11745	933	33	2		2	PDS5A	4	39929692	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	3799344	39929692	151224584	97	5244											
CHRNA9	55584	broad.mit.edu	37	chr4	40356015	40356015	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggtaaatactacatagccacGatggccctgatcacagcctc	12	8	8	13	1	1	1	1	1	0	0	2	2	1	1	3	2	4	1	3	2	5	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:40356015G>C	uc003gva.1	+	5	934	c.918G>C	c.(916-918)ACG>ACC	p.T306T		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	306	Helical; (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	ACATAGCCACGATGGCCCTGA	0.433													56	216					0	0	0	0	C	40356015	C	C	40356015	2	2	26	1	0	0	0	0	0	0	0	1	3404	1045	37	3		3	CHRNA9	4	40356015	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	426323	40356015	150798261	98	5245											
MOBKL1A	92597	broad.mit.edu	37	chr4	71835700	71835700	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatggaactatcacagacttCtgtacagaagagagttgtcc	13	11	9	8	0	2	3	1	0	1	3	3	5	3	4	1	1	2	2	1	1	5	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:71835700C>T	uc003hfw.2	+	3	424	c.234C>T	c.(232-234)TTC>TTT	p.F78F	MOBKL1A_uc003hfv.1_Silent_p.F78F|MOBKL1A_uc011cba.1_Silent_p.F83F	NM_173468	NP_775739	Q7L9L4	MOL1A_HUMAN	MOB1, Mps One Binder kinase activator-like 1A	78					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			TCACAGACTTCTGTACAGAAG	0.338													3	29					0	0	0	0	T	71835700	T	T	71835700	2	4	26	1	0	0	0	0	0	0	0	1	9735	912	32	2		2	MOBKL1A	4	71835700	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	31479685	71835700	119318576	99	5246											
GRIA2	2891	broad.mit.edu	37	chr4	158254442	158254442	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaatataaagtttgaccaGaatggaaaaagaataaacta	22	8	8	3	0	0	3	0	1	0	2	0	5	0	5	1	2	1	1	1	2	11	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr4:158254442G>C	uc003ipm.3	+	8	1551	c.1092G>C	c.(1090-1092)CAG>CAC	p.Q364H	GRIA2_uc011cit.1_Missense_Mutation_p.Q317H|GRIA2_uc003ipl.3_Missense_Mutation_p.Q364H|GRIA2_uc003ipk.3_Missense_Mutation_p.Q317H|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	364	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AGTTTGACCAGAATGGAAAAA	0.358													23	19					0	0	0	0	C	158254442	C	C	158254442	3	2	26	1	0	0	0	0	1	0	0	0	6807	933	33	2	1122	2	GRIA2	4	158254442	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	86418742	158254442	32899834	100	5247											
C5orf51	285636	broad.mit.edu	37	chr5	41904484	41904484	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggccatggcggccgcagtCtctagtgtggtgagacgagt	6	9	17	9	3	1	1	0	1	1	1	2	3	1	1	2	4	0	1	2	4	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:41904484C>G	uc003jmo.2	+	1	15	c.15C>G	c.(13-15)GTC>GTG	p.V5V		NM_175921	NP_787117	A6NDU8	CE051_HUMAN	hypothetical protein LOC285636	5											0						CGGCCGCAGTCTCTAGTGTGG	0.667													22	39					0	0	0	0	G	41904484	G	G	41904484	2	3	26	1	0	0	0	0	0	0	0	1	2318	900	32	2		2	C5orf51	5	41904484	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08		41904484	139010776	101	5248											
FBXO4	26272	broad.mit.edu	37	chr5	41934106	41934106	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cataaattcaacattctaatCttatattcaactaccaggta	16	14	2	9	0	4	0	2	0	2	0	4	0	4	0	1	1	3	1	1	1	9	9			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:41934106C>G	uc003jmq.2	+	4	761	c.705C>G	c.(703-705)ATC>ATG	p.I235M	FBXO4_uc003jmp.2_Missense_Mutation_p.I235M|FBXO4_uc003jmr.2_Missense_Mutation_p.I235M	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	235					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				ACATTCTAATCTTATATTCAA	0.328													16	69					0	0	0	0	G	41934106	G	G	41934106	3	3	26	1	0	0	0	0	1	0	0	0	5780	903	32	2	719	2	FBXO4	5	41934106	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	29622	41934106	138981154	102	5249											
ZNF608	57507	broad.mit.edu	37	chr5	123974878	123974878	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcctgggcagccacctgctGagaggcaacaagggcagcag	10	4	15	12	0	0	1	0	1	0	1	0	2	0	1	3	3	5	5	3	3	2	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:123974878G>C	uc003ktq.1	-	8	4603	c.4480C>G	c.(4480-4482)CAG>GAG	p.Q1494E	ZNF608_uc003ktr.1_RNA|ZNF608_uc003ktp.1_Missense_Mutation_p.Q189E	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1494						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCCACCTGCTGAGAGGCAACA	0.423													16	31					0	0	0	0	C	123974878	C	C	123974878	3	2	26	1	0	0	0	0	1	0	0	0	18101	1299	45	2	66	2	ZNF608	5	123974878	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	82040772	123974878	56940382	103	5250											
SEC24A	10802	broad.mit.edu	37	chr5	134060674	134060674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccttttattcctaagggatGagagtccaatgaaagcaaac	14	10	9	8	0	0	2	0	2	0	1	2	4	2	3	3	1	2	1	3	1	5	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:134060674G>A	uc003kzs.2	+	23	3460	c.3172G>A	c.(3172-3174)GAG>AAG	p.E1058K	SEC24A_uc011cxu.1_Missense_Mutation_p.E822K	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	1058					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTAAGGGATGAGAGTCCAAT	0.318													23	43					0	0	0	0	A	134060674	A	A	134060674	3	1	26	1	0	0	0	0	1	0	0	0	14059	1291	45	2	3262	2	SEC24A	5	134060674	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	10085796	134060674	46854586	104	5251											
PCDHGA4	56111	broad.mit.edu	37	chr5	140736827	140736827	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcagcagacccagacgactCgggcctcacactctatctcg	9	8	8	16	3	4	2	2	0	2	2	6	3	4	2	2	1	1	1	2	1	1	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:140736827C>T	uc003ljq.1	+	1	2060	c.2060C>T	c.(2059-2061)TCG>TTG	p.S687L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGB2_uc003ljs.1_5'Flank|PCDHGA4_uc003ljp.1_Missense_Mutation_p.S687L|PCDHGB2_uc011dar.1_5'Flank	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	687	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGACGACTCGGGCCTCACA	0.617													25	40					0	0	0	0	T	140736827	T	T	140736827	3	4	26	1	0	0	0	0	1	0	0	0	11610	893	31	1	2062	1	PCDHGA4	5	140736827	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	6676153	140736827	40178433	105	5252											
MFAP3	4238	broad.mit.edu	37	chr5	153433244	153433244	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatctaactgtaactacaaaGatggggcatatgaaaactgt	17	10	8	6	0	1	2	0	1	1	1	1	2	1	2	0	2	4	2	0	2	8	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:153433244G>C	uc003lvf.2	+	3	1576	c.1060G>C	c.(1060-1062)GAT>CAT	p.D354H	MFAP3_uc010jib.2_Missense_Mutation_p.D354H|MFAP3_uc011ddb.1_Missense_Mutation_p.D208H	NM_001135037	NP_001128509	P55082	MFAP3_HUMAN	microfibrillar-associated protein 3 isoform 2	354	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	Renal(175;0.00488)	Lung NSC(249;0.00145)|all_lung(500;0.00226)|all_neural(177;0.122)|Breast(839;0.14)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;9.69e-06)|GBM - Glioblastoma multiforme(465;0.0201)		TAACTACAAAGATGGGGCATA	0.408													25	36					0	0	0	0	C	153433244	C	C	153433244	3	2	26	1	0	0	0	0	1	0	0	0	9568	942	33	2	1066	2	MFAP3	5	153433244	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	12696417	153433244	27482016	106	5253											
ATP10B	23120	broad.mit.edu	37	chr5	160049574	160049574	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttggtcagtaggtttttatCtggagttacatctttttcct	6	20	8	7	0	3	0	1	0	2	0	4	1	4	1	1	3	1	3	1	3	3	8			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:160049574C>G	uc003lym.1	-	14	2486	c.1639G>C	c.(1639-1641)GAT>CAT	p.D547H	ATP10B_uc010jit.1_5'Flank|ATP10B_uc003lyn.2_Missense_Mutation_p.D105H	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	547	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGTTTTTATCTGGAGTTACA	0.507													45	65					0	0	0	0	G	160049574	G	G	160049574	3	3	26	1	0	0	0	0	1	0	0	0	1119	913	32	2	2798	2	ATP10B	5	160049574	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	6616330	160049574	20865686	107	5254											
ATP10B	23120	broad.mit.edu	37	chr5	160071214	160071214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctcgaagcagaagactctCacagccaaagccagtcctgg	12	5	10	14	1	1	2	1	0	1	2	4	3	2	2	4	1	3	1	4	1	3	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr5:160071214C>T	uc003lym.1	-	9	1646	c.799G>A	c.(799-801)GAG>AAG	p.E267K	ATP10B_uc003lyp.2_Missense_Mutation_p.E267K|ATP10B_uc011deg.1_Missense_Mutation_p.E311K|ATP10B_uc003lyo.2_Missense_Mutation_p.E239K	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	267	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGAAGACTCTCACAGCCAAAG	0.512													28	54					0	0	0	0	T	160071214	T	T	160071214	3	4	26	1	0	0	0	0	1	0	0	0	1119	835	29	2	3658	2	ATP10B	5	160071214	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	21640	160071214	20844046	108	5255											
SLC17A3	10786	broad.mit.edu	37	chr6	25862469	25862469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tatgttgcttacctttgcagGaagactctttggggctttac	7	16	10	8	0	1	1	0	0	1	1	1	2	1	2	1	3	4	4	1	3	4	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:25862469G>A	uc003nfi.3	-	3	405	c.295C>T	c.(295-297)CCT>TCT	p.P99S	SLC17A3_uc003nfk.3_Missense_Mutation_p.P99S|SLC17A3_uc011djz.1_Missense_Mutation_p.P99S|SLC17A3_uc011dka.1_Missense_Mutation_p.P99S	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	99					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						ACCTTTGCAGGAAGACTCTTT	0.383													17	14					0	0	0	0	A	25862469	A	A	25862469	3	1	26	1	0	0	0	0	1	0	0	0	14483	1174	41	2	1241	2	SLC17A3	6	25862469	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08		25862469	145252598	109	5256											
OR2B6	26212	broad.mit.edu	37	chr6	27925541	27925541	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgtgacccctatgtgataGatcactttctctgtgaagtc	8	15	8	10	0	3	4	1	3	2	1	5	4	3	4	2	0	0	0	2	0	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:27925541G>A	uc011dkx.1	+	1	523	c.523G>A	c.(523-525)GAT>AAT	p.D175N		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTATGTGATAGATCACTTTCT	0.483													51	39					0	0	0	0	A	27925541	A	A	27925541	3	1	26	1	0	0	0	0	1	0	0	0	11045	942	33	2	525	2	OR2B6	6	27925541	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2063072	27925541	143189526	110	5257											
DHX16	8449	broad.mit.edu	37	chr6	30624384	30624384	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccaatcacctaagctcttGagcagcaacacgacattgcc	12	7	7	15	1	2	1	1	1	1	0	2	2	2	1	3	0	5	3	3	0	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:30624384G>C	uc003nqz.2	-	14	2513	c.2301C>G	c.(2299-2301)CTC>CTG	p.L767L	DHX16_uc003nqy.2_Silent_p.L286L|DHX16_uc011dmo.1_Silent_p.L707L	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	767	Helicase C-terminal.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						CTAAGCTCTTGAGCAGCAACA	0.557													73	102					0	0	0	0	C	30624384	C	C	30624384	2	2	26	1	0	0	0	0	0	0	0	1	4524	1277	45	2		2	DHX16	6	30624384	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2698843	30624384	140490683	111	5258											
CFB	629	broad.mit.edu	37	chr6	31915793	31915793	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacctggtgctagatggaTcagacagcattggggccagc	9	9	13	10	0	2	2	1	0	1	2	2	3	2	3	2	4	4	2	2	4	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:31915793T>A	uc003nyj.3	+	6	1110	c.832T>A	c.(832-834)TCA>ACA	p.S278T	CFB_uc011dor.1_Missense_Mutation_p.S780T|CFB_uc003nyi.2_Missense_Mutation_p.S278T	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	278	VWFA.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						GCTAGATGGATCAGACAGCAT	0.537													30	42					0	0	0	0	A	31915793	A	A	31915793	3	1	26	1	0	0	0	0	1	0	0	0	3293	1435	50	5	854	5	CFB	6	31915793	Missense_Mutation	SNP	T	TCGA-BB-4227-01A-01D-1870-08	1291409	31915793	139199274	112	5259											
TAPBP	6892	broad.mit.edu	37	chr6	33272808	33272808	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gacctgtccttgcaggtatgGcaggtgtatggtggccagat	7	11	15	8	0	0	1	0	0	0	1	1	2	1	1	3	5	1	4	3	5	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:33272808G>A	uc003odx.1	-	4	997	c.826C>T	c.(826-828)CCA>TCA	p.P276S	TAPBP_uc010jus.1_Missense_Mutation_p.P294S|TAPBP_uc003ody.2_Missense_Mutation_p.P276S|TAPBP_uc003odz.2_Missense_Mutation_p.P276S|TAPBP_uc010jut.1_Missense_Mutation_p.P189S|TAPBP_uc011drc.1_Missense_Mutation_p.P276S	NM_003190	NP_003181	O15533	TPSN_HUMAN	tapasin isoform 1 precursor	276	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|immune response|peptide antigen stabilization|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|MHC class I peptide loading complex|microsome	MHC class I protein binding|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|unfolded protein binding			ovary(1)	1						TGCAGGTATGGCAGGTGTATG	0.587													108	138					0	0	0	0	A	33272808	A	A	33272808	3	1	26	1	0	0	0	0	1	0	0	0	15618	1203	42	4	720	4	TAPBP	6	33272808	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1357015	33272808	137842259	113	5260											
UHRF1BP1	54887	broad.mit.edu	37	chr6	34835329	34835329	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actgtggccctgcaagcagaGgaactgaccctccagcagct	10	6	11	14	0	0	2	0	1	0	1	1	3	1	3	3	2	5	4	3	2	2	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:34835329G>A	uc003oju.3	+	17	3888	c.3654G>A	c.(3652-3654)GAG>GAA	p.E1218E	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1218										ovary(3)	3						TGCAAGCAGAGGAACTGACCC	0.547													40	89					0	0	0	0	A	34835329	A	A	34835329	2	1	26	1	0	0	0	0	0	0	0	1	17036	991	35	4		4	UHRF1BP1	6	34835329	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1562521	34835329	136279738	114	5261											
LHFPL5	222662	broad.mit.edu	37	chr6	35773513	35773513	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaactatgtgcggaactcGcgagccgtgggcgtgatgtg	8	8	15	10	5	0	1	0	1	0	0	1	3	0	2	2	2	4	0	2	2	3	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:35773513G>A	uc003olg.1	+	1	443	c.66G>A	c.(64-66)TCG>TCA	p.S22S		NM_182548	NP_872354	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	22						integral to membrane				skin(1)	1						TGCGGAACTCGCGAGCCGTGG	0.617													30	122					0	0	0	0	A	35773513	A	A	35773513	2	1	26	1	0	0	0	0	0	0	0	1	8809	1074	38	1		1	LHFPL5	6	35773513	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	938184	35773513	135341554	115	5262											
ZNF318	24149	broad.mit.edu	37	chr6	43307216	43307216	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatggcagctggctgtgctGaggccatgatggctacaggc	8	8	16	9	0	0	2	0	2	0	0	0	3	0	2	1	5	3	5	1	5	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:43307216G>C	uc003oux.2	-	10	4598	c.4520C>G	c.(4519-4521)TCA>TGA	p.S1507*	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1507	Pro-rich.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TGGCTGTGCTGAGGCCATGAT	0.532													20	45					0	0	0	0	C	43307216	C	C	43307216	4	2	26	1	0	0	0	0	0	1	0	0	17903	1294	45	2	2323	2	ZNF318	6	43307216	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	7533703	43307216	127807851	116	5263											
ELOVL5	60481	broad.mit.edu	37	chr6	53138060	53138060	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttccaccagaggtatggAcgcatggaagggactgacga	11	8	13	9	2	1	2	0	1	1	1	2	6	2	5	2	4	0	2	2	4	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:53138060A>G	uc003pbq.1	-	6	1027	c.579T>C	c.(577-579)CGT>CGC	p.R193R	ELOVL5_uc003pbr.1_Silent_p.R193R|ELOVL5_uc011dwx.1_Silent_p.R220R|ELOVL5_uc003pbs.1_Intron|ELOVL5_uc003pbt.3_5'Flank	NM_021814	NP_068586	Q9NYP7	ELOV5_HUMAN	elongation of very long chain fatty acids-like	193				YFGATLNSFIHVLMYSYYGLSSVPSMRPYLWWKKYITQGQL LQFVLTIIQTSCGVIWPCTFPLGWLYFQIGYMISLIALFTN FYIQTYNKKGASRR -> SVCADNHPDQLRGHLAVHIPSWL VVFPDWIHDFPDCSLHKLLHSDLQQERGLPKERPPEGPPEW VHGCCEWTHQQLFTPGKQCEAKEAAEGLKSKN (in Ref. 4; BAD93035).	fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Lung NSC(77;0.116)					AGAGGTATGGACGCATGGAAG	0.502													3	119					0	0	0	0	G	53138060	G	G	53138060	2	3	26	1	0	0	0	0	0	0	0	1	5101	262	10	5		5	ELOVL5	6	53138060	Silent	SNP	A	TCGA-BB-4227-01A-01D-1870-08	9830844	53138060	117977007	117	5264											
FAM83B	222584	broad.mit.edu	37	chr6	54792428	54792428	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagtgatgtacggttcttaCaggtaagatcattgtgttta	12	15	10	4	1	2	2	1	1	1	1	2	2	2	2	0	2	2	4	0	2	5	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:54792428C>A	uc003pck.2	+	4	848	c.732C>A	c.(730-732)TAC>TAA	p.Y244*		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	244										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					ACGGTTCTTACAGGTAAGATC	0.299													44	83					2.74695e-27	2.9386e-27	1	0	A	54792428	A	A	54792428	4	1	26	1	0	0	0	0	0	1	0	0	5666	489	17	4	742	4	FAM83B	6	54792428	Nonsense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1654368	54792428	116322639	118	5265											
KHDC1	80759	broad.mit.edu	37	chr6	73951446	73951446	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcggacacgttccagcatctCcaggcctgcaaaataagtgc	11	8	9	13	2	1	0	0	0	1	0	4	1	2	1	3	2	3	3	3	2	3	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:73951446C>G	uc003pgo.2	-	5	1021	c.520G>C	c.(520-522)GAG>CAG	p.E174Q	KHDC1_uc011dyl.1_Intron|KHDC1_uc003pgn.3_Missense_Mutation_p.E101Q	NM_030568	NP_085045	Q4VXA5	KHDC1_HUMAN	KH homology domain containing 1	174						integral to membrane	RNA binding			skin(1)	1						TCCAGCATCTCCAGGCCTGCA	0.582													27	35					0	0	0	0	G	73951446	G	G	73951446	3	3	26	1	0	0	0	0	1	0	0	0	8183	864	30	2	197	2	KHDC1	6	73951446	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	19159018	73951446	97163621	119	5266											
ME1	4199	broad.mit.edu	37	chr6	83921771	83921771	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttctttgttttgcggttcagGataaactgtggctgtctttt	5	20	10	6	1	3	0	1	0	2	0	3	1	3	1	0	3	2	3	0	3	2	8			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:83921771G>A	uc003pjy.2	-	14	1697	c.1591C>T	c.(1591-1593)CCT>TCT	p.P531S	ME1_uc011dzb.1_Missense_Mutation_p.P456S|ME1_uc011dzc.1_Missense_Mutation_p.P365S	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	531					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	TGCGGTTCAGGATAAACTGTG	0.358													32	56					0	0	0	0	A	83921771	A	A	83921771	3	1	26	1	0	0	0	0	1	0	0	0	9470	1174	41	2	131	2	ME1	6	83921771	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	9970325	83921771	87193296	120	5267											
MAP3K7	6885	broad.mit.edu	37	chr6	91228236	91228236	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgccattttacaatgctgttCaaacactgccatagattctt	11	15	5	10	0	2	1	1	0	1	1	2	1	2	1	2	0	5	2	2	0	4	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:91228236C>G	uc003pnz.1	-	16	1732	c.1570G>C	c.(1570-1572)GAA>CAA	p.E524Q	MAP3K7_uc003pny.1_Missense_Mutation_p.E61Q|MAP3K7_uc003poa.1_Intron|MAP3K7_uc003pob.1_Missense_Mutation_p.E497Q|MAP3K7_uc003poc.1_Intron	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	524					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CAATGCTGTTCAAACACTGCC	0.284													11	24					0	0	0	0	G	91228236	G	G	91228236	3	3	26	1	0	0	0	0	1	0	0	0	9308	835	29	2	258	2	MAP3K7	6	91228236	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	7306465	91228236	79886831	121	5268											
HACE1	57531	broad.mit.edu	37	chr6	105281023	105281023	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcatggagtagttctgtcCgcccattcacagccagccaa	9	9	10	13	1	3	0	2	0	1	0	4	1	4	1	4	2	2	2	4	2	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:105281023C>T	uc003pqu.1	-	6	705	c.428G>A	c.(427-429)CGG>CAG	p.R143Q	HACE1_uc010kcy.1_5'UTR|HACE1_uc010kcz.1_Missense_Mutation_p.R143Q	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	143	ANK 3.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		TAGTTCTGTCCGCCCATTCAC	0.423													25	75					0	0	0	0	T	105281023	T	T	105281023	3	4	26	1	0	0	0	0	1	0	0	0	6979	652	23	1	2377	1	HACE1	6	105281023	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	14052787	105281023	65834044	122	5269											
IFNGR1	3459	broad.mit.edu	37	chr6	137540429	137540429	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcagccctgctcacaccCtgcatgacaaggggtaggag	10	7	11	13	0	2	1	2	1	1	0	3	2	2	2	2	3	3	3	2	3	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:137540429C>G	uc003qho.2	-	1	139	c.36G>C	c.(34-36)CAG>CAC	p.Q12H	IFNGR1_uc011edm.1_5'Flank|IFNGR1_uc011edn.1_5'UTR	NM_000416	NP_000407	P15260	INGR1_HUMAN	interferon gamma receptor 1 precursor	12					regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	TGCTCACACCCTGCATGACAA	0.692													12	21					0	0	0	0	G	137540429	G	G	137540429	3	3	26	1	0	0	0	0	1	0	0	0	7588	680	24	4	1461	4	IFNGR1	6	137540429	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	32259406	137540429	33574638	123	5270											
GPR126	57211	broad.mit.edu	37	chr6	142689043	142689043	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtttcaatgccagctacatCagaggtatgtaaaccaaagg	14	9	10	8	0	2	1	2	0	0	1	2	1	2	1	2	3	4	4	2	3	6	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:142689043C>G	uc010khc.2	+	3	852	c.441C>G	c.(439-441)ATC>ATG	p.I147M	GPR126_uc010khd.2_Missense_Mutation_p.I147M|GPR126_uc010khe.2_Missense_Mutation_p.I147M|GPR126_uc010khf.2_Missense_Mutation_p.I147M|GPR126_uc003qix.2_Missense_Mutation_p.I147M	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	147	CUB.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		CCAGCTACATCAGAGGTATGT	0.408													17	33					0	0	0	0	G	142689043	G	G	142689043	3	3	26	1	0	0	0	0	1	0	0	0	6678	816	29	2	451	2	GPR126	6	142689043	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	5148614	142689043	28426024	124	5271											
LATS1	9113	broad.mit.edu	37	chr6	149983190	149983190	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttaggaatgtatgaagcaGactgctgtctcaggtcactg	10	13	11	7	0	2	2	2	1	1	1	3	3	2	3	0	2	2	3	0	2	4	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:149983190G>C	uc003qmu.1	-	8	3616	c.3068C>G	c.(3067-3069)TCT>TGT	p.S1023C	LATS1_uc010kif.1_Missense_Mutation_p.S918C	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	1023	AGC-kinase C-terminal.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		GTATGAAGCAGACTGCTGTCT	0.388													14	107					0	0	0	0	C	149983190	C	C	149983190	3	2	26	1	0	0	0	0	1	0	0	0	8686	942	33	2	328	2	LATS1	6	149983190	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	7294147	149983190	21131877	125	5272											
LATS1	9113	broad.mit.edu	37	chr6	150001095	150001095	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaatatgaccatcacgatCaatcaaaatattatcaggtt	16	14	4	7	1	4	1	4	1	0	0	4	2	4	1	1	1	0	1	1	1	7	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:150001095C>G	uc003qmu.1	-	5	3057	c.2509G>C	c.(2509-2511)GAT>CAT	p.D837H	LATS1_uc010kif.1_Missense_Mutation_p.D732H|LATS1_uc003qmv.1_Missense_Mutation_p.D837H	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	837	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		CCATCACGATCAATCAAAATA	0.363													29	49					0	0	0	0	G	150001095	G	G	150001095	3	3	26	1	0	0	0	0	1	0	0	0	8686	826	29	2	899	2	LATS1	6	150001095	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	17905	150001095	21113972	126	5273											
MTRF1L	54516	broad.mit.edu	37	chr6	153311053	153311053	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactttttgggaaataatttCtactaaagattcataatcgg	15	15	6	5	1	2	1	1	0	1	1	3	2	2	2	0	2	2	0	0	2	7	8			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr6:153311053C>G	uc003qpi.3	-	7	1225	c.1120G>C	c.(1120-1122)GAA>CAA	p.E374Q	MTRF1L_uc003qpl.3_3'UTR|MTRF1L_uc011efa.1_Missense_Mutation_p.E338Q|MTRF1L_uc003qpj.3_Missense_Mutation_p.E232Q|MTRF1L_uc003qpk.3_3'UTR	NM_019041	NP_061914	Q9UGC7	RF1ML_HUMAN	mitochondrial translational release factor	374						mitochondrion	translation release factor activity, codon specific				0		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.24e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0888)		GAAATAATTTCTACTAAAGAT	0.333													37	80					0	0	0	0	G	153311053	G	G	153311053	3	3	26	1	0	0	0	0	1	0	0	0	10013	922	32	2	26	2	MTRF1L	6	153311053	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	3309958	153311053	17804014	127	5274											
PDGFA	5154	broad.mit.edu	37	chr7	552064	552064	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatggaccccgtgagctctCaggctggtgtccaaagaatc	9	8	12	12	1	1	2	1	1	1	1	4	3	2	3	3	3	1	3	3	3	2	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:552064C>G	uc003sir.2	-	3	1032	c.189G>C	c.(187-189)CTG>CTC	p.L63L	PDGFA_uc003sis.2_Silent_p.L63L|PDGFA_uc003sit.1_Silent_p.L77L	NM_002607	NP_002598	P04085	PDGFA_HUMAN	platelet-derived growth factor alpha isoform 1	63					actin cytoskeleton organization|angiogenesis|cell projection assembly|embryo development|hair follicle development|lung alveolus development|negative chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|organ morphogenesis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of DNA replication|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of MAP kinase activity|positive regulation of mesenchymal cell proliferation|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein kinase B signaling cascade|regulation of actin cytoskeleton organization|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|regulation of peptidyl-tyrosine phosphorylation|regulation of smooth muscle cell migration|skin development	cell surface|endoplasmic reticulum lumen|extracellular space|Golgi membrane|microvillus|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity				0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|Epithelial(4;1.1e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.7e-17)|all cancers(6;4.89e-15)		CGTGAGCTCTCAGGCTGGTGT	0.597													26	79					0	0	0	0	G	552064	G	G	552064	2	3	26	1	0	0	0	0	0	0	0	1	11711	813	29	2		2	PDGFA	7	552064	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08		552064	158586599	128	5275											
PMS2	5395	broad.mit.edu	37	chr7	6029573	6029573	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttttatctggagtaacattGatatcaacgcattctaaggc	12	14	7	8	1	3	1	1	1	2	0	3	2	3	2	0	2	2	2	0	2	5	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:6029573G>C	uc003spl.2	-	10	1089	c.1002C>G	c.(1000-1002)ATC>ATG	p.I334M	PMS2_uc003spj.2_Missense_Mutation_p.I228M|PMS2_uc003spk.2_Missense_Mutation_p.I199M|PMS2_uc011jwl.1_Missense_Mutation_p.I199M|PMS2_uc010ktg.2_Missense_Mutation_p.I23M|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Missense_Mutation_p.I334M	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	334					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		GAGTAACATTGATATCAACGC	0.239			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				36	35					0	0	0	0	C	6029573	C	C	6029573	3	2	26	1	0	0	0	0	1	0	0	0	12198	1280	45	2	1610	2	PMS2	7	6029573	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	5477509	6029573	153109090	129	5276											
NOD1	10392	broad.mit.edu	37	chr7	30492447	30492447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccaggatgaagatggtctCaccctgctcattgaggatgc	10	9	11	11	0	2	3	2	2	1	1	3	5	2	5	2	3	2	1	2	3	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:30492447C>T	uc003tav.2	-	6	1109	c.586G>A	c.(586-588)GAG>AAG	p.E196K	NOD1_uc010kvs.2_Intron	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	196	NACHT.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						AAGATGGTCTCACCCTGCTCA	0.627													42	13					0	0	0	0	T	30492447	T	T	30492447	3	4	26	1	0	0	0	0	1	0	0	0	10570	835	29	2	2311	2	NOD1	7	30492447	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	24462874	30492447	128646216	130	5277											
AUTS2	26053	broad.mit.edu	37	chr7	70227855	70227855	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttgctctctcccatgcaGatccggagttaggtgttggc	5	14	11	11	1	2	1	0	0	2	1	5	2	4	2	2	3	2	4	2	3	1	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:70227855G>T	uc003tvw.3	+	7	1486	c.743_splice	c.e7-1	p.D248_splice	AUTS2_uc003tvx.3_Splice_Site_p.D248_splice	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1											ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CTCCCATGCAGATCCGGAGTT	0.522													44	225					2.24722e-20	2.39011e-20	1	0	T	70227855	T	T	70227855	5	4	26	1	0	0	0	0	0	0	1	0	1227	956	33	2	913	2	AUTS2	7	70227855	Splice_Site	SNP	G	TCGA-BB-4227-01A-01D-1870-08	39735408	70227855	88910808	131	5278											
ARPC1B	10095	broad.mit.edu	37	chr7	98988657	98988657	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtctgtttctcagccagcggGagccgcgtggcctgggtaag	5	9	16	11	3	2	0	1	0	2	0	3	1	2	1	3	3	3	2	3	3	1	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:98988657G>A	uc003upz.2	+	6	731	c.642G>A	c.(640-642)GGG>GGA	p.G214G	ARPC1B_uc003uqa.2_Silent_p.G214G|ARPC1B_uc003uqb.2_Silent_p.G214G|ARPC1B_uc003uqc.2_Silent_p.G214G|ARPC1B_uc003uqd.2_Silent_p.G26G	NM_005720	NP_005711	O15143	ARC1B_HUMAN	actin related protein 2/3 complex subunit 1B	214					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			CAGCCAGCGGGAGCCGCGTGG	0.632													16	47					0	0	0	0	A	98988657	A	A	98988657	2	1	26	1	0	0	0	0	0	0	0	1	972	1161	41	2		2	ARPC1B	7	98988657	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	28760802	98988657	60150006	132	5279											
ZNF394	84124	broad.mit.edu	37	chr7	99097680	99097680	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagggtcccaactcggcgtCactgccgcgcctctgggcgg	4	6	14	17	5	2	0	1	0	1	0	4	0	3	0	4	4	2	0	4	4	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:99097680C>T	uc003uqs.2	-	1	198	c.37G>A	c.(37-39)GAC>AAC	p.D13N	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Missense_Mutation_p.D13N	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	13					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AACTCGGCGTCACTGCCGCGC	0.597													52	48					0	0	0	0	T	99097680	T	T	99097680	3	4	26	1	0	0	0	0	1	0	0	0	17947	826	29	2	1660	2	ZNF394	7	99097680	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	109023	99097680	60040983	133	5280											
C7orf51	222950	broad.mit.edu	37	chr7	100087172	100087172	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcctgtgcccacgtcatcGccagcgcagggacaccagag	8	6	11	16	3	2	1	1	0	1	1	4	2	2	2	4	1	2	1	4	1	0	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:100087172G>A	uc003uvd.1	+	4	1987	c.1828G>A	c.(1828-1830)GCC>ACC	p.A610T	C7orf51_uc003uve.1_Missense_Mutation_p.A392T	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	610										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCACGTCATCGCCAGCGCAGG	0.637													35	95					0	0	0	0	A	100087172	A	A	100087172	3	1	26	1	0	0	0	0	1	0	0	0	2411	1087	38	1	1838	1	C7orf51	7	100087172	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	989492	100087172	59051491	134	5281											
MUC17	140453	broad.mit.edu	37	chr7	100679095	100679095	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atacctgtcagcaacacgccGgtggccaattctgaggctag	10	8	11	12	2	2	1	1	1	1	0	2	1	2	1	3	3	3	2	3	3	4	3	rs149059191	byFrequency	TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:100679095G>C	uc003uxp.1	+	3	4451	c.4398G>C	c.(4396-4398)CCG>CCC	p.P1466P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1466	Extracellular (Potential).|Ser-rich.|22.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCAACACGCCGGTGGCCAATT	0.478													161	432					0	0	0	0	C	100679095	C	C	100679095	2	2	26	1	0	0	0	0	0	0	0	1	10027	1103	39	3		3	MUC17	7	100679095	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	591923	100679095	58459568	135	5282											
LAMB1	3912	broad.mit.edu	37	chr7	107601753	107601753	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcccttctcaaagcacacCggccgaggaaggacgacata	12	6	10	13	3	1	0	1	0	1	0	3	4	2	2	3	3	1	2	3	3	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:107601753C>T	uc003vew.2	-	17	2342	c.2007G>A	c.(2005-2007)CCG>CCA	p.P669P	LAMB1_uc003vev.2_Silent_p.P693P|LAMB1_uc003vex.2_Silent_p.P669P	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	669	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAAGCACACCGGCCGAGGAA	0.463													9	55					0	0	0	0	T	107601753	T	T	107601753	2	4	26	1	0	0	0	0	0	0	0	1	8650	639	23	1		1	LAMB1	7	107601753	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	6922658	107601753	51536910	136	5283											
IQUB	154865	broad.mit.edu	37	chr7	123109372	123109372	+	Frame_Shift_Del	DEL	T	-	-																															ttgcagctctctggctctgaTggtgaactgcgtatccatct																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:123109372delT	uc003vkn.2	-	9	2054	c.1477delA	c.(1477-1479)ATCfs	p.I493fs	IQUB_uc003vko.2_Frame_Shift_Del_p.I493fs|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Frame_Shift_Del_p.I493fs	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	493										ovary(3)|large_intestine(1)	4						CTGGCTCTGATGGTGAACTGC	0.353													---	---	---								-	123109372	-	-	123109372	7	5	26	1	0	1	0	1	0	0	0	0	7859	1464	51	0	918	0	IQUB	7	123109372	Frame_Shift_Del	DEL	T	TCGA-BB-4227-01A-01D-1870-08	15507619	123109372	36029291	137	5284											
OR2A14	135941	broad.mit.edu	37	chr7	143826410	143826410	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcacacctggccattgttGacatatcctatgcttccaac	9	13	5	14	0	1	1	1	1	1	0	4	1	3	1	4	1	2	2	4	1	3	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:143826410G>A	uc011kua.1	+	1	205	c.205G>A	c.(205-207)GAC>AAC	p.D69N		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GGCCATTGTTGACATATCCTA	0.463													79	140					0	0	0	0	A	143826410	A	A	143826410	3	1	26	1	0	0	0	0	1	0	0	0	11030	1290	45	2	207	2	OR2A14	7	143826410	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	20717038	143826410	15312253	138	5285											
KCNH2	3757	broad.mit.edu	37	chr7	150648119	150648119	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggatgaactcccgcacccGcagcatctgtgtgtggtagc	7	8	13	13	3	1	1	0	1	1	0	2	2	2	2	2	2	3	4	2	2	2	1	rs79624542		TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:150648119G>A	uc003wic.2	-	8	2048	c.2035C>T	c.(2035-2037)CGG>TGG	p.R679W	KCNH2_uc003wib.2_Missense_Mutation_p.R339W|KCNH2_uc011kux.1_Missense_Mutation_p.R583W|KCNH2_uc003wid.2_Missense_Mutation_p.R339W|KCNH2_uc003wie.2_Missense_Mutation_p.R679W	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	679	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TCCCGCACCCGCAGCATCTGT	0.632													27	32					0	0	0	0	A	150648119	A	A	150648119	3	1	26	1	0	0	0	0	1	0	0	0	8071	1086	38	1	1745	1	KCNH2	7	150648119	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	6821709	150648119	8490544	139	5286											
GALNTL5	168391	broad.mit.edu	37	chr7	151711769	151711769	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actctttataatcccctgctCtcgagtaggacatatcagta	11	13	6	11	1	3	0	1	0	2	0	5	2	4	1	2	1	1	3	2	1	5	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:151711769C>G	uc003wkp.2	+	8	1290	c.1067C>G	c.(1066-1068)TCT>TGT	p.S356C	GALNTL5_uc003wkq.2_Missense_Mutation_p.S107C|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.S245C	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	356	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		ATCCCCTGCTCTCGAGTAGGA	0.413													34	52					0	0	0	0	G	151711769	G	G	151711769	3	3	26	1	0	0	0	0	1	0	0	0	6259	913	32	2	1093	2	GALNTL5	7	151711769	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1063650	151711769	7426894	140	5287											
VIPR2	7434	broad.mit.edu	37	chr7	158823439	158823439	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcccggctcgcggacggggtCgggcaccggcttcgccattt	3	8	15	15	7	0	0	0	0	0	0	4	1	1	1	3	6	0	3	3	6	0	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr7:158823439C>G	uc003woh.2	-	13	1371	c.1185G>C	c.(1183-1185)CCG>CCC	p.P395P	VIPR2_uc010lqx.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	395	Cytoplasmic (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CGGACGGGGTCGGGCACCGGC	0.706													4	7					0	0	0	0	G	158823439	G	G	158823439	2	3	26	1	0	0	0	0	0	0	0	1	17238	871	31	3		3	VIPR2	7	158823439	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	7111670	158823439	315224	141	5288											
MTMR7	9108	broad.mit.edu	37	chr8	17228648	17228648	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttcttgcagcgaatcagcaGagggcatccggtagcggttg	8	9	15	9	3	2	1	1	0	1	1	3	2	3	1	1	3	4	6	1	3	2	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:17228648G>C	uc003wxm.2	-	3	447	c.208C>G	c.(208-210)CTG>GTG	p.L70V		NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	70							protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		CGAATCAGCAGAGGGCATCCG	0.453													6	94					0	0	0	0	C	17228648	C	C	17228648	3	2	26	1	0	0	0	0	1	0	0	0	10001	933	33	2	1822	2	MTMR7	8	17228648	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08		17228648	129135374	142	5289											
MTUS1	57509	broad.mit.edu	37	chr8	17613105	17613105	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacaccctgaaggcttaaaGaaatattttcaccagtaact	16	10	5	10	0	1	2	1	1	0	1	1	2	1	2	2	1	2	2	2	1	7	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:17613105G>A	uc003wxv.2	-	2	686	c.212C>T	c.(211-213)TCT>TTT	p.S71F	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.S71F|MTUS1_uc010lsz.2_Missense_Mutation_p.S71F	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	71						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		AAGGCTTAAAGAAATATTTTC	0.388													6	76					0	0	0	0	A	17613105	A	A	17613105	3	1	26	1	0	0	0	0	1	0	0	0	10018	942	33	2	3975	2	MTUS1	8	17613105	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	384457	17613105	128750917	143	5290											
SLC39A14	23516	broad.mit.edu	37	chr8	22262337	22262337	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccctgggtgcaccagctatCagcgctgcctccttcctgca	5	10	9	17	1	1	0	1	0	0	0	4	0	4	0	5	1	5	4	5	1	1	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:22262337C>G	uc003xbq.3	+	2	289	c.114C>G	c.(112-114)ATC>ATG	p.I38M	SLC39A14_uc011kzg.1_Missense_Mutation_p.I38M|SLC39A14_uc003xbp.3_Missense_Mutation_p.I38M|SLC39A14_uc011kzh.1_Missense_Mutation_p.I38M	NM_001128431	NP_001121903	Q15043	S39AE_HUMAN	solute carrier family 39 (zinc transporter),	38	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity				0				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)		CACCAGCTATCAGCGCTGCCT	0.602													3	76					0	0	0	0	G	22262337	G	G	22262337	3	3	26	1	0	0	0	0	1	0	0	0	14681	816	29	2	116	2	SLC39A14	8	22262337	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	4649232	22262337	124101685	144	5291											
ANK1	286	broad.mit.edu	37	chr8	41545690	41545690	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcacctgcccagctgagaccGaggtgctctgagataacagc	10	7	11	13	1	2	2	1	2	1	2	2	5	2	2	3	1	5	2	3	1	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:41545690G>C	uc003xok.2	-	35	4326	c.4242C>G	c.(4240-4242)CTC>CTG	p.L1414L	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Silent_p.L730L|ANK1_uc003xoi.2_Silent_p.L1414L|ANK1_uc003xoj.2_Silent_p.L1414L|ANK1_uc003xol.2_Silent_p.L1414L|ANK1_uc003xom.2_Silent_p.L1455L	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1414	55 kDa regulatory domain.|Death.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			AGCTGAGACCGAGGTGCTCTG	0.512													76	43					0	0	0	0	C	41545690	C	C	41545690	2	2	26	1	0	0	0	0	0	0	0	1	620	1045	37	3		3	ANK1	8	41545690	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	19283353	41545690	104818332	145	5292											
NSMAF	8439	broad.mit.edu	37	chr8	59522253	59522253	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaggcgtcaccatttctgcTttgcattccatgtgcagctt	7	14	9	11	1	2	1	1	0	1	1	3	1	3	1	2	1	4	4	2	1	0	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:59522253T>C	uc003xtt.2	-	10	811	c.597A>G	c.(595-597)AAA>AAG	p.K199K	NSMAF_uc011lee.1_Silent_p.K230K|NSMAF_uc003xtu.2_Silent_p.K199K	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	199	GRAM.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				CCATTTCTGCTTTGCATTCCA	0.428													57	32					0	0	0	0	C	59522253	C	C	59522253	2	2	26	1	0	0	0	0	0	0	0	1	10728	1606	56	5		5	NSMAF	8	59522253	Silent	SNP	T	TCGA-BB-4227-01A-01D-1870-08	17976563	59522253	86841769	146	5293											
ARFGEF1	10565	broad.mit.edu	37	chr8	68208741	68208741	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggctgttgtctgattgatGagatttttgcttgctaagta	7	19	11	4	0	1	3	0	3	1	1	1	4	1	3	0	1	2	5	0	1	2	8			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:68208741G>A	uc003xxo.1	-	5	954	c.564C>T	c.(562-564)CTC>CTT	p.L188L		NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	188					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TCTGATTGATGAGATTTTTGC	0.378													42	101					0	0	0	0	A	68208741	A	A	68208741	2	1	26	1	0	0	0	0	0	0	0	1	852	1277	45	2		2	ARFGEF1	8	68208741	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	8686488	68208741	78155281	147	5294											
SULF1	23213	broad.mit.edu	37	chr8	70539481	70539481	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgactctatccattgtgaGagagaactgtaccaatcggc	13	10	9	9	1	1	3	0	2	1	2	3	5	2	3	2	1	2	1	2	1	5	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:70539481G>C	uc010lza.1	+	16	2604	c.1887G>C	c.(1885-1887)GAG>GAC	p.E629D	SULF1_uc003xyd.2_Missense_Mutation_p.E629D|SULF1_uc003xye.2_Missense_Mutation_p.E629D|SULF1_uc003xyf.2_Missense_Mutation_p.E629D|SULF1_uc003xyg.2_Missense_Mutation_p.E629D|SULF1_uc003xyh.1_RNA|SULF1_uc003xyi.1_5'Flank	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	629					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TCCATTGTGAGAGAGAACTGT	0.388													8	64					0	0	0	0	C	70539481	C	C	70539481	3	2	26	1	0	0	0	0	1	0	0	0	15436	933	33	2	1933	2	SULF1	8	70539481	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2330740	70539481	75824541	148	5295											
CNGB3	54714	broad.mit.edu	37	chr8	87645092	87645092	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccaatggtaattaaagttCgaactgcccaataataacat	17	10	5	9	1	0	0	0	0	0	0	1	1	0	0	2	1	3	2	2	1	8	5	rs147876778	byFrequency	TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:87645092C>T	uc003ydx.2	-	11	1254	c.1208G>A	c.(1207-1209)CGA>CAA	p.R403Q	CNGB3_uc010maj.2_Missense_Mutation_p.R265Q	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	403	Cytoplasmic (Potential).		R -> Q (in macular degeneration).		signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						AATTAAAGTTCGAACTGCCCA	0.328													18	42					0	0	0	0	T	87645092	T	T	87645092	3	4	26	1	0	0	0	0	1	0	0	0	3616	884	31	1	1253	1	CNGB3	8	87645092	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	17105611	87645092	58718930	149	5296											
ESRP1	54845	broad.mit.edu	37	chr8	95653588	95653588	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtggtgctttttgggatCactgctggggccaccggggc	3	12	17	9	1	1	0	1	0	0	0	1	1	1	1	2	7	2	2	2	7	0	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:95653588C>T	uc003ygq.3	+	1	225	c.42C>T	c.(40-42)ATC>ATT	p.I14I	ESRP1_uc003ygr.3_Silent_p.I14I|ESRP1_uc003ygs.3_Silent_p.I14I|ESRP1_uc003ygt.3_Silent_p.I14I|ESRP1_uc003ygu.3_Silent_p.I14I	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	14					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						TTTTTGGGATCACTGCTGGGG	0.587													10	88					0	0	0	0	T	95653588	T	T	95653588	2	4	26	1	0	0	0	0	0	0	0	1	5282	816	29	2		2	ESRP1	8	95653588	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	8008496	95653588	50710434	150	5297											
ABRA	137735	broad.mit.edu	37	chr8	107782023	107782023	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaagcacaccagcatccctCtcgtacctgtggctgaggtg	8	9	10	14	1	2	1	1	1	1	0	4	1	3	1	3	2	3	4	3	2	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:107782023C>T	uc003ymm.3	-	1	450	c.396G>A	c.(394-396)GAG>GAA	p.E132E		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	132					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CAGCATCCCTCTCGTACCTGT	0.542													62	155					0	0	0	0	T	107782023	T	T	107782023	2	4	26	1	0	0	0	0	0	0	0	1	100	912	32	2		2	ABRA	8	107782023	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	12128435	107782023	38581999	151	5298											
KCNV1	27012	broad.mit.edu	37	chr8	110980590	110980590	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcccgataatatacacatGaaggccacgattttgcctgt	12	12	7	10	2	0	1	0	1	0	0	1	3	1	1	3	1	2	0	3	1	4	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:110980590G>A	uc003ynr.3	-	3	1572	c.1230C>T	c.(1228-1230)TTC>TTT	p.F410F	KCNV1_uc010mcw.2_Silent_p.F410F	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	410	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			ATATACACATGAAGGCCACGA	0.478													39	123					0	0	0	0	A	110980590	A	A	110980590	2	1	26	1	0	0	0	0	0	0	0	1	8133	1281	45	2		2	KCNV1	8	110980590	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	3198567	110980590	35383432	152	5299											
TRIB1	10221	broad.mit.edu	37	chr8	126445719	126445719	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcactcctatgtgcgaagccGgaagaggctgcgggaagagg	10	5	17	9	3	0	2	0	0	0	2	1	5	1	4	2	4	3	2	2	4	4	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:126445719G>A	uc003yrx.2	+	2	1103	c.521G>A	c.(520-522)CGG>CAG	p.R174Q	TRIB1_uc011lis.1_Missense_Mutation_p.R8Q|TRIB1_uc010mdn.2_5'Flank	NM_025195	NP_079471	Q96RU8	TRIB1_HUMAN	G-protein-coupled receptor induced protein	174	Protein kinase.				JNK cascade|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|response to lipopolysaccharide	cytoplasm|nucleus	ATP binding|mitogen-activated protein kinase kinase binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			lung(1)	1	all_hematologic(1;4.97e-05)|Ovarian(258;0.00167)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			GTGCGAAGCCGGAAGAGGCTG	0.572													94	202					0	0	0	0	A	126445719	A	A	126445719	3	1	26	1	0	0	0	0	1	0	0	0	16549	1116	39	1	527	1	TRIB1	8	126445719	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	15465129	126445719	19918303	153	5300											
PUF60	22827	broad.mit.edu	37	chr8	144902849	144902849	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattgaccgattgcaaaggtGagagaggatctccaaagccc	13	8	11	9	1	1	3	0	2	1	1	2	6	1	4	3	2	2	1	3	2	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:144902849G>C	uc003yzs.2	-	5	399	c.335C>G	c.(334-336)TCA>TGA	p.S112*	PUF60_uc003yzr.2_Intron|PUF60_uc003yzt.2_Intron|PUF60_uc003yzq.2_Nonsense_Mutation_p.S69*|PUF60_uc003yzu.1_Nonsense_Mutation_p.S101*	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	112	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TTGCAAAGGTGAGAGAGGATC	0.547													78	246					0	0	0	0	C	144902849	C	C	144902849	4	2	26	1	0	0	0	0	0	1	0	0	12889	1294	45	2	1376	2	PUF60	8	144902849	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	18457130	144902849	1461173	154	5301											
PLEC	5339	broad.mit.edu	37	chr8	144990596	144990596	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggtggactgcgcggcagcctCcagcagccgcagccccgtgc	5	4	15	17	4	0	0	0	0	0	0	1	1	1	1	5	3	6	3	5	3	0	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:144990596C>G	uc003zaf.1	-	32	13974	c.13804G>C	c.(13804-13806)GAG>CAG	p.E4602Q	PLEC_uc003zab.1_Missense_Mutation_p.E4465Q|PLEC_uc003zac.1_Missense_Mutation_p.E4469Q|PLEC_uc003zad.2_Missense_Mutation_p.E4465Q|PLEC_uc003zae.1_Missense_Mutation_p.E4433Q|PLEC_uc003zag.1_Missense_Mutation_p.E4443Q|PLEC_uc003zah.2_Missense_Mutation_p.E4451Q|PLEC_uc003zaj.2_Missense_Mutation_p.E4492Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4602	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCGGCAGCCTCCAGCAGCCGC	0.677													57	151					0	0	0	0	G	144990596	G	G	144990596	3	3	26	1	0	0	0	0	1	0	0	0	12107	864	30	2	254	2	PLEC	8	144990596	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	87747	144990596	1373426	155	5302											
PARP10	84875	broad.mit.edu	37	chr8	145052088	145052088	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctcaccgttgcggccgcaGaagctgcggttgaagccgtg	6	7	15	13	5	1	2	1	1	0	1	1	2	1	2	4	2	4	4	4	2	2	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr8:145052088G>C	uc003zal.3	-	10	2826	c.2718C>G	c.(2716-2718)TTC>TTG	p.F906L	PLEC_uc003zaj.2_5'Flank|PARP10_uc003zak.3_Missense_Mutation_p.F603L|PARP10_uc011lku.1_Missense_Mutation_p.F918L|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Missense_Mutation_p.F897L	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	906	PARP catalytic.|Myc binding.					Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCGGCCGCAGAAGCTGCGGT	0.721													7	38					0	0	0	0	C	145052088	C	C	145052088	3	2	26	1	0	0	0	0	1	0	0	0	11509	933	33	2	367	2	PARP10	8	145052088	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	61492	145052088	1311934	156	5303											
NTRK2	4915	broad.mit.edu	37	chr9	87636301	87636301	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atcaagggcatccataccctCcttcagaacttggccaaggc	11	8	8	14	0	2	1	2	0	0	1	4	1	4	1	4	3	2	1	4	3	4	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:87636301C>G	uc004aoa.1	+	20	3356	c.2418C>G	c.(2416-2418)CTC>CTG	p.L806L	NTRK2_uc004anz.1_Silent_p.L822L	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	806	Protein kinase.|Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						TCCATACCCTCCTTCAGAACT	0.597										TSP Lung(25;0.17)			88	16					0	0	0	0	G	87636301	G	G	87636301	2	3	26	1	0	0	0	0	0	0	0	1	10761	842	30	2		2	NTRK2	9	87636301	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08		87636301	53577130	157	5304											
DAB2IP	153090	broad.mit.edu	37	chr9	124530800	124530800	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcgcttcctgctggagatctCcaaccccgagaccctctcca	7	8	8	18	2	2	2	0	0	2	2	5	4	3	2	6	1	2	2	6	1	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:124530800C>G	uc004bln.2	+	10	1772	c.1703C>G	c.(1702-1704)TCC>TGC	p.S568C	DAB2IP_uc004blo.2_Missense_Mutation_p.S472C|DAB2IP_uc004blp.2_Missense_Mutation_p.S23C	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	596					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						CTGGAGATCTCCAACCCCGAG	0.587													5	141					0	0	0	0	G	124530800	G	G	124530800	3	3	26	1	0	0	0	0	1	0	0	0	4236	855	30	2	1741	2	DAB2IP	9	124530800	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	36894499	124530800	16682631	158	5305											
OR1B1	347169	broad.mit.edu	37	chr9	125391590	125391590	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggggcagtgtaactgtggaTagccccatgtctatcacaga	10	10	12	9	0	2	1	1	0	1	1	2	2	2	2	2	3	2	2	2	3	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:125391590T>G	uc011lyz.1	-	1	225	c.225A>C	c.(223-225)CTA>CTC	p.L75L		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TAACTGTGGATAGCCCCATGT	0.522													48	10					0	0	0	0	G	125391590	G	G	125391590	2	3	26	1	0	0	0	0	0	0	0	1	11005	1393	49	5		5	OR1B1	9	125391590	Silent	SNP	T	TCGA-BB-4227-01A-01D-1870-08	860790	125391590	15821841	159	5306											
TTF1	7270	broad.mit.edu	37	chr9	135266215	135266215	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactccaagcaccacgatttCtttctgtagatataaaaaga	15	12	5	9	1	2	2	0	0	2	2	3	3	3	2	2	0	2	2	2	0	7	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:135266215C>G	uc004cbl.2	-	7	2043	c.1991G>C	c.(1990-1992)AGA>ACA	p.R664T	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Missense_Mutation_p.R149T	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	664	Myb-like 2.				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ACCACGATTTCTTTCTGTAGA	0.358													107	26					0	0	0	0	G	135266215	G	G	135266215	3	3	26	1	0	0	0	0	1	0	0	0	16786	913	32	2	746	2	TTF1	9	135266215	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	9874625	135266215	5947216	160	5307											
RNF208	727800	broad.mit.edu	37	chr9	140114909	140114909	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagcaggcggacagtgggttCcgcacgtggcaggtgcacgc	7	5	18	11	4	0	0	0	0	0	0	1	2	1	1	1	5	2	5	1	5	0	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:140114909C>T	uc004clz.1	-	1	867	c.756G>A	c.(754-756)CGG>CGA	p.R252R		NM_031297	NP_112587	Q9H0X6	RN208_HUMAN	ring finger protein 208	252							zinc ion binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		ACAGTGGGTTCCGCACGTGGC	0.701													17	8					0	0	0	0	T	140114909	T	T	140114909	2	4	26	1	0	0	0	0	0	0	0	1	13540	842	30	2		2	RNF208	9	140114909	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	4848694	140114909	1098522	161	5308											
EXD3	54932	broad.mit.edu	37	chr9	140249213	140249213	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcgctgctgaatggccgcgTtgggacacagcgctgaaagg	8	6	17	10	4	0	2	0	2	0	0	0	3	0	3	1	4	2	4	1	4	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr9:140249213T>C	uc004cmp.2	-	9	966	c.770A>G	c.(769-771)AAC>AGC	p.N257S	C9orf167_uc011mew.1_Intron|EXD3_uc010ncf.1_5'UTR|EXD3_uc004cmq.1_Intron|EXD3_uc010ncg.1_Missense_Mutation_p.N196S	NM_017820	NP_060290	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	257					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						AATGGCCGCGTTGGGACACAG	0.697													28	5					0	0	0	0	C	140249213	C	C	140249213	3	2	26	1	0	0	0	0	1	0	0	0	5323	1725	60	5	1916	5	EXD3	9	140249213	Missense_Mutation	SNP	T	TCGA-BB-4227-01A-01D-1870-08	134304	140249213	964218	162	5309											
UPF2	26019	broad.mit.edu	37	chr10	12070767	12070767	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttttgtctctcagtattctgGagctccctgtggtccctttt	3	19	8	11	0	3	0	1	0	2	0	6	1	5	1	2	2	1	2	2	2	1	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:12070767G>C	uc001ila.2	-	2	1596	c.1122C>G	c.(1120-1122)CTC>CTG	p.L374L	UPF2_uc001ilb.2_Silent_p.L374L|UPF2_uc001ilc.2_Silent_p.L374L|UPF2_uc009xiz.1_Silent_p.L374L	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	374	MIF4G 1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				CAGTATTCTGGAGCTCCCTGT	0.373													37	43					0	0	0	0	C	12070767	C	C	12070767	2	2	26	1	0	0	0	0	0	0	0	1	17072	1161	41	2		2	UPF2	10	12070767	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08		12070767	123463980	163	5310											
STAM	8027	broad.mit.edu	37	chr10	17737124	17737124	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatccaagcacatccagtctCttaactaaccaccaacatga	15	9	3	14	0	1	1	0	1	1	0	4	1	3	1	4	0	4	1	4	0	5	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:17737124C>T	uc001ipj.1	+	7	828	c.612C>T	c.(610-612)CTC>CTT	p.L204L	STAM_uc010qcf.1_Silent_p.L93L|STAM_uc009xjw.1_5'UTR	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	204					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2						CATCCAGTCTCTTAACTAACC	0.388													30	51					0	0	0	0	T	17737124	T	T	17737124	2	4	26	1	0	0	0	0	0	0	0	1	15314	900	32	2		2	STAM	10	17737124	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	5666357	17737124	117797623	164	5311											
ARMC4	55130	broad.mit.edu	37	chr10	28151401	28151401	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caataaaggaacaactccatGatctgtgataacagctaaat	18	9	6	8	0	1	2	0	2	1	0	2	3	2	3	1	1	4	1	1	1	8	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:28151401G>A	uc009xky.2	-	18	2859	c.2761C>T	c.(2761-2763)CAT>TAT	p.H921Y	ARMC4_uc010qds.1_Missense_Mutation_p.H446Y|ARMC4_uc010qdt.1_Missense_Mutation_p.H613Y|ARMC4_uc001itz.2_Missense_Mutation_p.H921Y	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	921	ARM 8.						binding			ovary(4)|skin(2)	6						ACAACTCCATGATCTGTGATA	0.303													50	90					0	0	0	0	A	28151401	A	A	28151401	3	1	26	1	0	0	0	0	1	0	0	0	955	1290	45	2	385	2	ARMC4	10	28151401	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	10414277	28151401	107383346	165	5312											
ARMC4	55130	broad.mit.edu	37	chr10	28151529	28151529	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gttccaaaccaccaacaaagGaacgaaccatttccccagca	16	5	5	15	1	0	0	0	0	0	0	2	2	2	1	6	1	5	2	6	1	5	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:28151529G>T	uc009xky.2	-	18	2731	c.2633C>A	c.(2632-2634)TCC>TAC	p.S878Y	ARMC4_uc010qds.1_Missense_Mutation_p.S403Y|ARMC4_uc010qdt.1_Missense_Mutation_p.S570Y|ARMC4_uc001itz.2_Missense_Mutation_p.S878Y	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	878	ARM 7.						binding			ovary(4)|skin(2)	6						ACCAACAAAGGAACGAACCAT	0.348													15	17					4.7546e-09	4.9011e-09	1	0	T	28151529	T	T	28151529	3	4	26	1	0	0	0	0	1	0	0	0	955	1174	41	2	513	2	ARMC4	10	28151529	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	128	28151529	107383218	166	5313											
ANK3	288	broad.mit.edu	37	chr10	61822996	61822996	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgattaatttttgtcaagacCgaagttaaggcatcagctga	13	12	9	7	2	2	2	2	1	0	1	2	4	2	2	1	1	1	3	1	1	4	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:61822996C>T	uc001jky.2	-	40	12660	c.12468G>A	c.(12466-12468)TCG>TCA	p.S4156S	ANK3_uc001jkw.2_Silent_p.S677S|ANK3_uc009xpa.2_Silent_p.S677S|ANK3_uc001jkx.2_Silent_p.S721S|ANK3_uc010qih.1_Silent_p.S1544S|ANK3_uc001jkz.3_Silent_p.S1537S|ANK3_uc001jkv.2_Silent_p.S76S	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	4156	Death.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTGTCAAGACCGAAGTTAAGG	0.348													12	15					0	0	0	0	T	61822996	T	T	61822996	2	4	26	1	0	0	0	0	0	0	0	1	622	639	23	1		1	ANK3	10	61822996	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	33671467	61822996	73711751	167	5314											
MYPN	84665	broad.mit.edu	37	chr10	69881286	69881286	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagacatcggggaaacaatGagaggagtcgagcggagccc	13	3	15	10	3	0	2	0	1	0	2	2	7	0	5	2	4	3	0	2	4	2	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:69881286G>T	uc001jnm.3	+	3	276	c.91G>T	c.(91-93)GAG>TAG	p.E31*	MYPN_uc001jnl.1_Nonsense_Mutation_p.E31*|MYPN_uc001jnn.3_Intron|MYPN_uc001jno.3_Nonsense_Mutation_p.E31*|MYPN_uc001jnp.1_Nonsense_Mutation_p.E31*|MYPN_uc009xps.2_Nonsense_Mutation_p.E31*|MYPN_uc009xpt.2_Nonsense_Mutation_p.E31*|MYPN_uc010qit.1_5'UTR|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	31	Interaction with CARP.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						GGGAAACAATGAGAGGAGTCG	0.522													13	73					9.31168e-06	9.51861e-06	1	0	T	69881286	T	T	69881286	4	4	26	1	0	0	0	0	0	1	0	0	10151	1291	45	2	93	2	MYPN	10	69881286	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	8058290	69881286	65653461	168	5315											
HKDC1	80201	broad.mit.edu	37	chr10	70992626	70992626	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcagatggagagtcagttCtacccaacgcccaatgaaat	13	8	10	10	1	2	3	1	1	1	2	2	4	2	3	2	1	3	2	2	1	4	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:70992626C>G	uc001jpf.3	+	3	466	c.333C>G	c.(331-333)TTC>TTG	p.F111L	HKDC1_uc010qje.1_5'Flank	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	111					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						AGAGTCAGTTCTACCCAACGC	0.602													75	109					0	0	0	0	G	70992626	G	G	70992626	3	3	26	1	0	0	0	0	1	0	0	0	7232	912	32	2	343	2	HKDC1	10	70992626	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1111340	70992626	64542121	169	5316											
SAMD8	142891	broad.mit.edu	37	chr10	76928341	76928341	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtagtctgatgggaactgtAttcttgcttcgctgctttac	6	17	10	8	1	2	1	0	1	2	0	3	2	2	2	0	1	4	5	0	1	4	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:76928341A>G	uc001jwx.1	+	4	820	c.717A>G	c.(715-717)GTA>GTG	p.V239V	SAMD8_uc001jwy.1_Silent_p.V239V	NM_144660	NP_653261	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	239	Helical; (Potential).				sphingomyelin biosynthetic process	integral to membrane					0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TGGGAACTGTATTCTTGCTTC	0.458													82	136					0	0	0	0	G	76928341	G	G	76928341	2	3	26	1	0	0	0	0	0	0	0	1	13890	436	16	5		5	SAMD8	10	76928341	Silent	SNP	A	TCGA-BB-4227-01A-01D-1870-08	5935715	76928341	58606406	170	5317											
GSTO1	9446	broad.mit.edu	37	chr10	106019428	106019428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagttctggaaaacagtcagGgtcagctgatctacgagtct	11	10	11	9	1	5	1	2	1	3	0	5	3	5	2	0	2	3	2	0	2	3	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr10:106019428G>A	uc001kya.2	+	3	247	c.238G>A	c.(238-240)GGT>AGT	p.G80S		NM_004832	NP_004823	P78417	GSTO1_HUMAN	glutathione-S-transferase omega 1	80	GST N-terminal.				xenobiotic metabolic process	cytosol	glutathione transferase activity|monodehydroascorbate reductase (NADH) activity				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;8.07e-10)|all cancers(201;2.72e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0147)	Glutathione(DB00143)	AAACAGTCAGGGTCAGCTGAT	0.468													43	63					0	0	0	0	A	106019428	A	A	106019428	3	1	26	1	0	0	0	0	1	0	0	0	6881	1232	43	4	248	4	GSTO1	10	106019428	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	29091087	106019428	29515319	171	5318											
UBQLN3	50613	broad.mit.edu	37	chr11	5529368	5529368	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccggggatggcagccagggaGgctcagggattccaggaatg	9	5	18	9	1	1	0	1	0	0	0	2	4	2	4	3	7	1	2	3	7	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:5529368G>T	uc001may.1	-	2	1507	c.1421C>A	c.(1420-1422)CCT>CAT	p.P474H	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	474										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGCCAGGGAGGCTCAGGGAT	0.552													29	18					3.65163e-15	3.86149e-15	1	0	T	5529368	T	T	5529368	3	4	26	1	0	0	0	0	1	0	0	0	16966	1000	35	4	550	4	UBQLN3	11	5529368	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08		5529368	129477148	172	5319											
OR52B2	255725	broad.mit.edu	37	chr11	6191434	6191434	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atcaggatgctgtttcccagGactgcagtgatgtaaatgag	11	11	12	7	0	1	2	1	2	0	0	2	4	2	4	1	2	2	4	1	2	2	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:6191434G>A	uc010qzy.1	-	1	123	c.123C>T	c.(121-123)GTC>GTT	p.V41V		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTTTCCCAGGACTGCAGTGA	0.478													34	17					0	0	0	0	A	6191434	A	A	6191434	2	1	26	1	0	0	0	0	0	0	0	1	11165	1161	41	2		2	OR52B2	11	6191434	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	662066	6191434	128815082	173	5320											
APBB1	322	broad.mit.edu	37	chr11	6422239	6422239	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caacaggtttagcaacaggtAcattccccaggtaatagact	14	9	8	10	0	0	1	0	0	0	1	1	1	1	1	2	3	4	4	2	3	6	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:6422239A>G	uc001mdb.1	-	11	1752	c.1652T>C	c.(1651-1653)GTA>GCA	p.V551A	APBB1_uc001mcz.1_Missense_Mutation_p.V170A|APBB1_uc001mdd.3_Missense_Mutation_p.V329A|APBB1_uc001mda.2_Missense_Mutation_p.V76A|APBB1_uc001mdc.1_Missense_Mutation_p.V549A|APBB1_uc010rab.1_Missense_Mutation_p.V76A	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	551	PID 2.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		AGCAACAGGTACATTCCCCAG	0.478													9	216					0	0	0	0	G	6422239	G	G	6422239	3	3	26	1	0	0	0	0	1	0	0	0	759	391	14	5	496	5	APBB1	11	6422239	Missense_Mutation	SNP	A	TCGA-BB-4227-01A-01D-1870-08	230805	6422239	128584277	174	5321											
MICAL2	9645	broad.mit.edu	37	chr11	12248645	12248645	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccatttctaataactatctCaacctcacatttccaaggaa	14	13	2	12	0	3	0	2	0	2	0	6	1	5	1	3	1	2	0	3	1	6	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:12248645C>G	uc001mjz.2	+	15	2250	c.1962C>G	c.(1960-1962)CTC>CTG	p.L654L	MICAL2_uc010rch.1_Silent_p.L654L|MICAL2_uc001mka.2_Silent_p.L654L|MICAL2_uc010rci.1_Silent_p.L654L|MICAL2_uc001mkb.2_Silent_p.L654L|MICAL2_uc001mkc.2_Silent_p.L654L|MICAL2_uc001mkd.2_Silent_p.L483L|MICAL2_uc010rcj.1_Silent_p.L56L	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	654						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		ATAACTATCTCAACCTCACAT	0.443													15	7					0	0	0	0	G	12248645	G	G	12248645	2	3	26	1	0	0	0	0	0	0	0	1	9623	813	29	2		2	MICAL2	11	12248645	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	5826406	12248645	122757871	175	5322											
CSTF3	1479	broad.mit.edu	37	chr11	33182907	33182907	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caacgtgcgcactgaccgtcGatgggaagctagaaaagaaa	15	5	12	9	4	0	3	0	1	0	2	1	5	0	4	1	1	3	2	1	1	6	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:33182907G>C	uc001muh.2	-	1	131	c.-35C>G	c.(-37--33)ATCGA>ATGGA		CSTF3_uc001mui.2_Translation_Start_Site|CSTF3_uc001muj.2_Translation_Start_Site|uc001muk.2_5'Flank	NM_001326	NP_001317	Q12996	CSTF3_HUMAN	cleavage stimulation factor subunit 3 isoform 1						mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding				0						ACTGACCGTCGATGGGAAGCT	0.557											OREG0020867	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	20					0	0	0	0	C	33182907	C	C	33182907	1	2	26	1	0	0	0	0	0	0	0	0	4003	1073	37	3		3	CSTF3	11	33182907	Translation_Start_Site	SNP	G	TCGA-BB-4227-01A-01D-1870-08	20934262	33182907	101823609	176	5323											
CREB3L1	90993	broad.mit.edu	37	chr11	46341831	46341831	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccagtgccctcccgaagcctCctattctacgatgacggggc	7	8	10	16	3	1	1	0	1	1	0	3	3	3	1	5	2	3	0	5	2	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:46341831C>G	uc001ncf.2	+	11	1710	c.1275C>G	c.(1273-1275)CTC>CTG	p.L425L	CREB3L1_uc001ncg.2_Silent_p.L59L	NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	425	Lumenal (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)		CCCGAAGCCTCCTATTCTACG	0.557			T	FUS	myxofibrosarcoma								13	29					0	0	0	0	G	46341831	G	G	46341831	2	3	26	1	0	0	0	0	0	0	0	1	3871	842	30	2		2	CREB3L1	11	46341831	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	13158924	46341831	88664685	177	5324											
PTPMT1	114971	broad.mit.edu	37	chr11	47587500	47587500	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcggggtgatcaccatgaacGaggagtacgagacgaggttc	11	6	16	8	4	1	3	1	2	0	1	2	7	1	4	1	4	2	2	1	4	2	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:47587500G>C	uc001nfs.3	+	2	410	c.217G>C	c.(217-219)GAG>CAG	p.E73Q	PTPMT1_uc001nfv.3_Missense_Mutation_p.R109P|PTPMT1_uc009ylt.2_Missense_Mutation_p.E73Q|PTPMT1_uc001nfu.3_Missense_Mutation_p.R109P|NDUFS3_uc001nft.3_5'UTR	NM_175732	NP_783859	Q8WUK0	PTPM1_HUMAN	protein tyrosine phosphatase, mitochondrial 1	73					inositol phosphate dephosphorylation	mitochondrial inner membrane	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(1)	1						CACCATGAACGAGGAGTACGA	0.677													14	58					0	0	0	0	C	47587500	C	C	47587500	3	2	26	1	0	0	0	0	1	0	0	0	12841	1059	37	3	328	3	PTPMT1	11	47587500	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1245669	47587500	87419016	178	5325											
OR8H1	219469	broad.mit.edu	37	chr11	56058397	56058397	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggaggtccaggcggattaTcaatatcatccccacattgc	10	10	9	12	1	2	0	2	0	0	0	4	2	4	2	3	4	1	0	3	4	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:56058397T>G	uc010rje.1	-	1	142	c.142A>C	c.(142-144)ATA>CTA	p.I48L		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					AGGCGGATTATCAATATCATC	0.423													75	201					0	0	0	0	G	56058397	G	G	56058397	3	3	26	1	0	0	0	0	1	0	0	0	11291	1435	50	5	795	5	OR8H1	11	56058397	Missense_Mutation	SNP	T	TCGA-BB-4227-01A-01D-1870-08	8470897	56058397	78948119	179	5326											
UBXN1	51035	broad.mit.edu	37	chr11	62445293	62445293	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtccctctcgatcttttctCtaactctttgtctgaaatgt	6	19	5	11	1	5	1	0	1	5	0	8	2	6	1	1	0	1	0	1	0	2	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:62445293C>T	uc001nul.1	-	6	626	c.494G>A	c.(493-495)AGA>AAA	p.R165K	UBXN1_uc001nuj.2_Missense_Mutation_p.R165K|UBXN1_uc001num.1_Missense_Mutation_p.R161K|UBXN1_uc001nuk.2_Missense_Mutation_p.R130K|UBXN1_uc010rme.1_Missense_Mutation_p.R165K	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	165	Potential.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						GATCTTTTCTCTAACTCTTTG	0.433													50	105					0	0	0	0	T	62445293	T	T	62445293	3	4	26	1	0	0	0	0	1	0	0	0	16979	913	32	2	456	2	UBXN1	11	62445293	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	6386896	62445293	72561223	180	5327											
RASGRP2	10235	broad.mit.edu	37	chr11	64507521	64507521	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcgatactccaagtaggtGagatgctccgccagctccat	10	8	11	12	2	0	1	0	1	0	1	3	4	3	1	4	1	4	3	4	1	3	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:64507521G>T	uc009ypu.2	-	6	713	c.486C>A	c.(484-486)CTC>CTA	p.L162L	RASGRP2_uc001oat.2_Silent_p.L64L|RASGRP2_uc001oau.2_Silent_p.L17L|RASGRP2_uc009ypv.2_Silent_p.L162L|RASGRP2_uc009ypw.2_Silent_p.L162L	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	162	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						CCAAGTAGGTGAGATGCTCCG	0.607													12	82					5.16669e-11	5.41692e-11	1	0	T	64507521	T	T	64507521	2	4	26	1	0	0	0	0	0	0	0	1	13140	1277	45	2		2	RASGRP2	11	64507521	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2062228	64507521	70498995	181	5328											
SF1	7536	broad.mit.edu	37	chr11	64534668	64534668	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagacagccattacctttTccttgatgcaggcgatagac	11	10	9	11	1	0	3	0	1	0	2	1	4	1	3	3	1	4	2	3	1	2	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:64534668T>C	uc001obb.1	-	11	1775	c.1398A>G	c.(1396-1398)GGA>GGG	p.G466G	SF1_uc010rnm.1_Silent_p.G158G|SF1_uc010rnn.1_Silent_p.G440G|SF1_uc001oaz.1_Silent_p.G591G|SF1_uc001oba.1_Silent_p.G466G|SF1_uc001obc.1_Silent_p.G466G|SF1_uc001obd.1_Missense_Mutation_p.K468E|SF1_uc001obe.1_Missense_Mutation_p.K353E|SF1_uc010rno.1_Silent_p.G351G	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	466	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						CATTACCTTTTCCTTGATGCA	0.562													40	61					0	0	0	0	C	64534668	C	C	64534668	2	2	26	1	0	0	0	0	0	0	0	1	14210	1792	62	5		5	SF1	11	64534668	Silent	SNP	T	TCGA-BB-4227-01A-01D-1870-08	27147	64534668	70471848	182	5329											
SHANK2	22941	broad.mit.edu	37	chr11	70332212	70332212	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccaagtccacggatgccaGagggggaggagggatgcgga	11	4	18	8	2	0	1	0	0	0	1	2	6	2	6	3	6	2	0	3	6	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:70332212G>T	uc001oqc.2	-	21	4264	c.4186C>A	c.(4186-4188)CTG>ATG	p.L1396M	SHANK2_uc010rqn.1_Missense_Mutation_p.L808M|SHANK2_uc001opz.2_Missense_Mutation_p.L801M|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1017					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACGGATGCCAGAGGGGGAGGA	0.582													34	457					4.92203e-23	5.25016e-23	1	0	T	70332212	T	T	70332212	3	4	26	1	0	0	0	0	1	0	0	0	14330	933	33	2	1371	2	SHANK2	11	70332212	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	5797544	70332212	64674304	183	5330											
DLG2	1740	broad.mit.edu	37	chr11	84245714	84245714	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gagttctgggcctcttacttCgtgggttagtcgaggtaagg	6	13	15	7	2	2	0	0	0	2	0	4	2	2	0	1	4	1	3	1	4	3	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:84245714C>G	uc001paj.2	-	2	406	c.103G>C	c.(103-105)GAA>CAA	p.E35Q	DLG2_uc010rsz.1_Missense_Mutation_p.E35Q|DLG2_uc010rta.1_Missense_Mutation_p.E35Q|DLG2_uc001pak.2_Missense_Mutation_p.E140Q|DLG2_uc001pal.1_Missense_Mutation_p.E35Q	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	35						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding	p.E35E(1)		ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CCTCTTACTTCGTGGGTTAGT	0.398													47	83					0	0	0	0	G	84245714	G	G	84245714	3	3	26	1	0	0	0	0	1	0	0	0	4577	893	31	3	2756	3	DLG2	11	84245714	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	13913502	84245714	50760802	184	5331											
BIRC2	329	broad.mit.edu	37	chr11	102233700	102233700	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagatatcctcatcttcttGaacaggtaaatacattttta	13	16	5	7	0	3	2	1	1	2	1	4	2	4	2	1	1	2	2	1	1	7	9			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:102233700G>C	uc001pgy.2	+	4	2468	c.1069G>C	c.(1069-1071)GAA>CAA	p.E357Q	BIRC2_uc010ruq.1_Missense_Mutation_p.E308Q|BIRC2_uc010rur.1_Missense_Mutation_p.E357Q	NM_001166	NP_001157	Q13490	BIRC2_HUMAN	baculoviral IAP repeat-containing protein 2	357					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		TCATCTTCTTGAACAGGTAAA	0.224													8	184					0	0	0	0	C	102233700	C	C	102233700	3	2	26	1	0	0	0	0	1	0	0	0	1438	1291	45	2	1079	2	BIRC2	11	102233700	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	17987986	102233700	32772816	185	5332											
MMP27	64066	broad.mit.edu	37	chr11	102562560	102562560	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaataaacaagcttaaactCttatgatacaatatctttat	19	14	2	6	0	2	1	0	1	2	0	2	1	2	1	0	0	4	1	0	0	12	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:102562560C>G	uc001phd.1	-	10	1502	c.1479G>C	c.(1477-1479)AAG>AAC	p.K493N		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	493					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		AGCTTAAACTCTTATGATACA	0.299													32	585					0	0	0	0	G	102562560	G	G	102562560	3	3	26	1	0	0	0	0	1	0	0	0	9717	912	32	2	66	2	MMP27	11	102562560	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	328860	102562560	32443956	186	5333											
MMP8	4317	broad.mit.edu	37	chr11	102592421	102592421	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atgagaggtgatgcaacactCcagagttcaaaggcatcctt	13	9	10	9	0	1	3	1	2	0	2	3	4	3	3	2	2	2	3	2	2	2	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:102592421C>G	uc001phe.2	-	3	519	c.420G>C	c.(418-420)TGG>TGC	p.W140C	MMP8_uc010rut.1_Missense_Mutation_p.W75C|MMP8_uc010ruu.1_Missense_Mutation_p.W117C	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	140					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		ATGCAACACTCCAGAGTTCAA	0.448													21	350					0	0	0	0	G	102592421	G	G	102592421	3	3	26	1	0	0	0	0	1	0	0	0	9721	856	30	2	1015	2	MMP8	11	102592421	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	29861	102592421	32414095	187	5334											
MMP1	4312	broad.mit.edu	37	chr11	102666324	102666324	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagttcatgagctgcaacacGatgtaagttgtactctaaaa	14	11	9	7	1	2	1	1	1	1	0	2	3	2	1	0	0	4	6	0	0	5	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:102666324G>A	uc001phi.2	-	5	783	c.640C>T	c.(640-642)CGT>TGT	p.R214C	uc001phh.1_Intron|MMP1_uc010ruv.1_Missense_Mutation_p.R148C	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	214	Metalloprotease.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		GCTGCAACACGATGTAAGTTG	0.368													15	168					0	0	0	0	A	102666324	A	A	102666324	3	1	26	1	0	0	0	0	1	0	0	0	9701	1058	37	1	793	1	MMP1	11	102666324	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	73903	102666324	32340192	188	5335											
ARHGAP32	9743	broad.mit.edu	37	chr11	128844701	128844701	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actccaatgtctggtgggctCaagtcaacatcctcagctga	10	10	9	12	0	4	1	3	1	1	0	6	1	6	1	2	2	2	2	2	2	3	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr11:128844701C>T	uc009zcp.2	-	20	2349	c.2349G>A	c.(2347-2349)TTG>TTA	p.L783L	ARHGAP32_uc009zcq.1_Silent_p.L743L|ARHGAP32_uc009zco.2_5'UTR|ARHGAP32_uc001qez.2_Silent_p.L434L	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	783					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						CTGGTGGGCTCAAGTCAACAT	0.483													25	10					0	0	0	0	T	128844701	T	T	128844701	2	4	26	1	0	0	0	0	0	0	0	1	881	825	29	2		2	ARHGAP32	11	128844701	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	26178377	128844701	6161815	189	5336											
LRP6	4040	broad.mit.edu	37	chr12	12302048	12302048	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcatagggttgtatttccaGgttctgactcggaactgagc	8	13	12	8	1	2	2	1	2	1	0	4	3	3	3	1	3	2	3	1	3	3	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:12302048G>T	uc001rah.3	-	14	3176	c.3034C>A	c.(3034-3036)CTG>ATG	p.L1012M	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.L1012M	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1012	LDL-receptor class B 16.|Extracellular (Potential).|Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				TGTATTTCCAGGTTCTGACTC	0.428													94	147					1.41219e-46	1.51512e-46	1	0	T	12302048	T	T	12302048	3	4	26	1	0	0	0	0	1	0	0	0	9012	991	35	4	1847	4	LRP6	12	12302048	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08		12302048	121549847	190	5337											
KIAA1467	57613	broad.mit.edu	37	chr12	13221564	13221564	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tactttgtccttatttgcagCcagcctactcctggatattt	7	17	6	11	0	0	0	0	0	0	0	2	1	2	1	4	1	5	1	4	1	4	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:13221564C>T	uc001rbi.2	+	9	1310	c.1287C>T	c.(1285-1287)AGC>AGT	p.S429S	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	429						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TTATTTGCAGCCAGCCTACTC	0.418													39	72					0	0	0	0	T	13221564	T	T	13221564	2	4	26	1	0	0	0	0	0	0	0	1	8274	753	26	4		4	KIAA1467	12	13221564	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	919516	13221564	120630331	191	5338											
PDE3A	5139	broad.mit.edu	37	chr12	20782960	20782977	+	In_Frame_Del	DEL	AACTGCCAAACAAAGCCT	-	-																															tttccagaatctgctgacacAactgccaaacaaagcctagg																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:20782960_20782977delAACTGCCAAACAAAGCCT	uc001reh.1	+	6	1681_1698	c.1659_1676delAACTGCCAAACAAAGCCT	c.(1657-1677)ACAACTGCCAAACAAAGCCTA>ACA	p.TAKQSL554del		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	554_559					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTGCTGACACAACTGCCAAACAAAGCCTAGGTTCTCAC	0.5													---	---	---								-	20782977	-	-	20782960	7	5	26	1	0	1	0	1	0	0	0	0	11691	117	5	0	1681	0	PDE3A	12	20782960	In_Frame_Del	DEL	AACTGCCAAACAAAGCCT	TCGA-BB-4227-01A-01D-1870-08	7561396	20782960	113068935	192	5339											
IRAK3	11213	broad.mit.edu	37	chr12	66603284	66603284	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatcaggaaggtggatttcCaaatatattattcaaggtag	14	14	9	4	0	2	0	2	0	0	0	3	2	3	2	1	4	0	1	1	4	8	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:66603284C>T	uc001sth.2	+	3	467	c.365C>T	c.(364-366)CCA>CTA	p.P122L	IRAK3_uc010ssy.1_Missense_Mutation_p.P61L	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	122					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		GGTGGATTTCCAAATATATTA	0.353													21	53					0	0	0	0	T	66603284	T	T	66603284	3	4	26	1	0	0	0	0	1	0	0	0	7863	594	21	4	375	4	IRAK3	12	66603284	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	45820324	66603284	67248611	193	5340											
KCNC2	3747	broad.mit.edu	37	chr12	75601539	75601539	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgccgccctcgaagcagccGcctggcccgggggacagcgg	5	2	17	17	6	0	0	0	0	0	0	1	2	0	1	5	4	3	1	5	4	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:75601539G>A	uc001sxg.1	-	2	769	c.225C>T	c.(223-225)GGC>GGT	p.G75G	KCNC2_uc009zry.2_Silent_p.G75G|KCNC2_uc001sxe.2_Silent_p.G75G|KCNC2_uc001sxf.2_Silent_p.G75G|KCNC2_uc010stw.1_Silent_p.G75G	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	75	Gly/Pro-rich (insert).|Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						CGAAGCAGCCGCCTGGCCCGg	0.537													7	1					0	0	0	0	A	75601539	A	A	75601539	2	1	26	1	0	0	0	0	0	0	0	1	8054	1074	38	1		1	KCNC2	12	75601539	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	8998255	75601539	58250356	194	5341											
C12orf63	374467	broad.mit.edu	37	chr12	97102560	97102560	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	taattaccaacaagagcaaaCcaaacctaccaaacttggaa	20	6	4	11	0	0	1	0	0	0	1	0	2	0	2	4	1	7	1	4	1	9	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:97102560C>A	uc001tet.1	+	15	2056	c.1978C>A	c.(1978-1980)CCA>ACA	p.P660T		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	660										skin(6)|ovary(1)	7						CAAGAGCAAACCAAACCTACC	0.348													20	41					1.01871e-10	1.06502e-10	1	0	A	97102560	A	A	97102560	3	1	26	1	0	0	0	0	1	0	0	0	1712	507	18	4	2032	4	C12orf63	12	97102560	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	21501021	97102560	36749335	195	5342											
RNFT2	84900	broad.mit.edu	37	chr12	117217096	117217096	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttctgaagtacatcaccatCgccctcaagtgcctcatcgt	9	11	7	14	2	4	1	3	1	1	0	6	1	4	1	3	0	2	2	3	0	3	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:117217096C>T	uc009zwn.2	+	7	1058	c.825C>T	c.(823-825)ATC>ATT	p.I275I	RNFT2_uc001twb.3_Silent_p.I275I|RNFT2_uc001twa.3_Silent_p.I185I|RNFT2_uc001twc.3_Silent_p.I23I	NM_001109903	NP_001103373	Q96EX2	RNFT2_HUMAN	transmembrane protein 118 isoform 1	275	Helical; (Potential).					integral to membrane	zinc ion binding				0	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		ACATCACCATCGCCCTCAAGT	0.552													60	81					0	0	0	0	T	117217096	T	T	117217096	2	4	26	1	0	0	0	0	0	0	0	1	13567	874	31	1		1	RNFT2	12	117217096	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	20114536	117217096	16634799	196	5343											
ANAPC5	51433	broad.mit.edu	37	chr12	121756175	121756175	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaggagcatgggcagcgCgatggtaggggaggaagatc	10	5	19	7	2	0	1	0	0	0	1	1	5	0	4	0	6	3	4	0	6	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:121756175C>T	uc001uag.2	-	15	1920	c.1798G>A	c.(1798-1800)GCG>ACG	p.A600T	ANAPC5_uc010szu.1_Missense_Mutation_p.A266T|ANAPC5_uc001uae.2_Missense_Mutation_p.A164T|ANAPC5_uc010szv.1_Missense_Mutation_p.A202T|ANAPC5_uc001uaf.2_RNA|ANAPC5_uc001uah.2_Missense_Mutation_p.A488T|ANAPC5_uc001uai.1_Intron	NM_016237	NP_057321	Q9UJX4	APC5_HUMAN	anaphase-promoting complex subunit 5 isoform a	600	TPR 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			skin(3)|breast(2)|kidney(1)	6	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATGGGCAGCGCGATGGTAGGG	0.552													33	47					0	0	0	0	T	121756175	T	T	121756175	3	4	26	1	0	0	0	0	1	0	0	0	605	768	27	1	481	1	ANAPC5	12	121756175	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	4539079	121756175	12095720	197	5344											
DDX51	317781	broad.mit.edu	37	chr12	132627321	132627321	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgcagctgcttctgcaggtCaggatggacgtcagggatgt	7	9	15	10	2	3	0	2	0	1	0	3	3	3	3	1	4	3	4	1	4	0	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:132627321C>G	uc001ujy.3	-	3	661	c.622G>C	c.(622-624)GAC>CAC	p.D208H	NOC4L_uc001ujz.1_5'Flank	NM_175066	NP_778236	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	208					rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			lung(1)|pancreas(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		TTCTGCAGGTCAGGATGGACG	0.617													48	93					0	0	0	0	G	132627321	G	G	132627321	3	3	26	1	0	0	0	0	1	0	0	0	4386	826	29	2	1430	2	DDX51	12	132627321	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	10871146	132627321	1224574	198	5345											
GOLGA3	2802	broad.mit.edu	37	chr12	133350895	133350895	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagagctggcctcgcctttCggctcctttctctgttttta	4	16	9	12	2	1	1	0	0	1	1	5	2	2	1	3	2	1	3	3	2	2	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr12:133350895C>T	uc001ukz.1	-	23	4714	c.4155G>A	c.(4153-4155)CCG>CCA	p.P1385P		NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1385	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CCTCGCCTTTCGGCTCCTTTC	0.617													28	49					0	0	0	0	T	133350895	T	T	133350895	2	4	26	1	0	0	0	0	0	0	0	1	6591	871	31	1		1	GOLGA3	12	133350895	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	723574	133350895	501000	199	5346											
RNF31	55072	broad.mit.edu	37	chr14	24617533	24617533	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatgggttgagcttccccGaagggcaggaggagccagat	10	6	16	9	1	0	3	0	1	0	2	1	6	1	5	3	4	2	3	3	4	1	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:24617533G>T	uc001wmn.1	+	3	655	c.406G>T	c.(406-408)GAA>TAA	p.E136*	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_5'UTR|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_5'UTR|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	136	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GAGCTTCCCCGAAGGGCAGGA	0.567													14	38					7.93312e-07	8.132e-07	1	0	T	24617533	T	T	24617533	4	4	26	1	0	0	0	0	0	1	0	0	13552	1059	37	3	416	3	RNF31	14	24617533	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08		24617533	82732007	200	5347											
MDGA2	161357	broad.mit.edu	37	chr14	47426688	47426688	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcgtactctgtgtattcctGagagtcaaattgacccgtcc	9	12	9	11	2	2	2	1	2	1	1	4	3	4	2	3	0	2	2	3	0	3	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:47426688G>A	uc001wwj.3	-	9	1967	c.1771C>T	c.(1771-1773)CAG>TAG	p.Q591*	MDGA2_uc001wwi.3_Nonsense_Mutation_p.Q362*|MDGA2_uc010ani.2_Nonsense_Mutation_p.Q151*	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	591	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GTGTATTCCTGAGAGTCAAAT	0.448													39	67					0	0	0	0	A	47426688	A	A	47426688	4	1	26	1	0	0	0	0	0	1	0	0	9460	1299	45	2	1135	2	MDGA2	14	47426688	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	22809155	47426688	59922852	201	5348											
SYNE2	23224	broad.mit.edu	37	chr14	64476717	64476717	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggagagttttggagctcttAaaacaatatcagaattttaa	15	13	9	4	0	2	2	1	0	1	2	2	4	2	3	0	2	2	2	0	2	6	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:64476717A>T	uc001xgm.2	+	32	4841	c.4611A>T	c.(4609-4611)TTA>TTT	p.L1537F	SYNE2_uc001xgl.2_Missense_Mutation_p.L1537F	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1537	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGGAGCTCTTAAAACAATATC	0.353													18	32					0	0	0	0	T	64476717	T	T	64476717	3	4	26	1	0	0	0	0	1	0	0	0	15512	359	13	5	4733	5	SYNE2	14	64476717	Missense_Mutation	SNP	A	TCGA-BB-4227-01A-01D-1870-08	17050029	64476717	42872823	202	5349											
HSPA2	3306	broad.mit.edu	37	chr14	65008483	65008483	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccatcacgcgcgcccgcttcGaggagctcaatgccgacctc	7	6	10	18	6	2	0	2	0	0	0	4	3	2	1	4	1	2	2	4	1	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:65008483G>C	uc001xhj.2	+	2	992	c.916G>C	c.(916-918)GAG>CAG	p.E306Q	HSPA2_uc001xhk.3_Missense_Mutation_p.E306Q	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	306					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		CGCCCGCTTCGAGGAGCTCAA	0.652													10	19					0	0	0	0	C	65008483	C	C	65008483	3	2	26	1	0	0	0	0	1	0	0	0	7450	1059	37	3	918	3	HSPA2	14	65008483	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	531766	65008483	42341057	203	5350											
TSHR	7253	broad.mit.edu	37	chr14	81610641	81610641	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactgattgaaaactcccatCtaaccccaaagaagcaaggc	17	6	6	12	0	1	3	0	2	1	1	2	3	2	3	3	1	4	1	3	1	7	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:81610641C>T	uc001xvd.1	+	10	2395	c.2239C>T	c.(2239-2241)CTA>TTA	p.L747L		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	747	Cytoplasmic (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	AAACTCCCATCTAACCCCAAA	0.408			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						38	67					0	0	0	0	T	81610641	T	T	81610641	2	4	26	1	0	0	0	0	0	0	0	1	16689	912	32	2		2	TSHR	14	81610641	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	16602158	81610641	25738899	204	5351											
ZC3H14	79882	broad.mit.edu	37	chr14	89039315	89039315	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttagaagaaacgtatagtccGttctttagaaacaactcgga	15	11	8	7	3	1	3	0	0	1	3	3	4	2	4	1	1	3	2	1	1	8	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:89039315G>A	uc001xww.2	+	6	1050	c.825G>A	c.(823-825)CCG>CCA	p.P275P	ZC3H14_uc010twd.1_Silent_p.P275P|ZC3H14_uc010twe.1_Silent_p.P275P|ZC3H14_uc001xwx.2_Silent_p.P275P|ZC3H14_uc010twf.1_Silent_p.P120P|ZC3H14_uc001xwy.2_Silent_p.P241P|ZC3H14_uc010twg.1_Silent_p.P120P|ZC3H14_uc001xxa.2_5'Flank	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	275						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						CGTATAGTCCGTTCTTTAGAA	0.388													4	80					0	0	0	0	A	89039315	A	A	89039315	2	1	26	1	0	0	0	0	0	0	0	1	17633	1132	40	1		1	ZC3H14	14	89039315	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	7428674	89039315	18310225	205	5352											
EML5	161436	broad.mit.edu	37	chr14	89131807	89131807	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacggctaaagctttaccatCaggagaaaaacagcaacacc	17	6	7	11	1	1	1	1	0	0	1	1	2	1	1	2	2	6	3	2	2	7	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:89131807C>T	uc001xxg.2	-	23	3337	c.3151G>A	c.(3151-3153)GAT>AAT	p.D1051N	EML5_uc001xxf.2_5'UTR|EML5_uc001xxh.1_Missense_Mutation_p.D190N	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1051	WD 17.					cytoplasm|microtubule				ovary(3)	3						GCTTTACCATCAGGAGAAAAA	0.348													33	57					0	0	0	0	T	89131807	T	T	89131807	3	4	26	1	0	0	0	0	1	0	0	0	5124	826	29	2	2870	2	EML5	14	89131807	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	92492	89131807	18217733	206	5353											
EML5	161436	broad.mit.edu	37	chr14	89192964	89192964	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgcattgacagctgcacaacGaattggttcttccatattac	11	13	7	10	1	1	1	0	1	1	0	2	2	2	1	1	1	5	4	1	1	4	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:89192964G>C	uc001xxg.2	-	9	1294	c.1108C>G	c.(1108-1110)CGT>GGT	p.R370G		NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	370						cytoplasm|microtubule				ovary(3)	3						GCTGCACAACGAATTGGTTCT	0.368													3	14					0	0	0	0	C	89192964	C	C	89192964	3	2	26	1	0	0	0	0	1	0	0	0	5124	1058	37	3	4969	3	EML5	14	89192964	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	61157	89192964	18156576	207	5354											
MOAP1	64112	broad.mit.edu	37	chr14	93650551	93650551	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccgagggttcatgtccaTccccctgcaccagtcttcta	6	13	7	15	1	3	0	1	0	2	0	6	1	6	0	5	1	1	2	5	1	1	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:93650551T>C	uc001ybj.2	-	3	407	c.37A>G	c.(37-39)ATG>GTG	p.M13V	C14orf109_uc001ybk.3_5'Flank|C14orf109_uc010auo.2_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	13					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			skin(2)|ovary(1)	3		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		ttcatgtccatccccctgcac	0.085													5	169					0	0	0	0	C	93650551	C	C	93650551	3	2	26	1	0	0	0	0	1	0	0	0	9733	1435	50	5	1022	5	MOAP1	14	93650551	Missense_Mutation	SNP	T	TCGA-BB-4227-01A-01D-1870-08	4457587	93650551	13698989	208	5355											
JAG2	3714	broad.mit.edu	37	chr14	105609974	105609974	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggtccctggcagggctgaagGactgcggcaaagaacggcat	10	5	16	10	2	0	2	0	1	0	1	1	3	1	3	1	6	2	4	1	6	3	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr14:105609974G>C	uc001yqg.2	-	25	3490	c.3086C>G	c.(3085-3087)TCC>TGC	p.S1029C	JAG2_uc010axf.2_5'UTR|JAG2_uc001yqf.2_Missense_Mutation_p.S433C|JAG2_uc001yqh.2_Missense_Mutation_p.S991C	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	1029	Extracellular (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		AGGGCTGAAGGACTGCGGCAA	0.682													5	60					0	0	0	0	C	105609974	C	C	105609974	3	2	26	1	0	0	0	0	1	0	0	0	7974	1188	41	2	638	2	JAG2	14	105609974	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	11959423	105609974	1739566	209	5356											
CYFIP1	23191	broad.mit.edu	37	chr15	22997806	22997806	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctgctctagtctttagaaGaagtgtgtgacctgctgcac	8	13	10	10	0	3	3	0	1	3	2	3	3	3	3	1	0	3	3	1	0	4	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:22997806G>C	uc001yus.2	+	27	3156	c.3052G>C	c.(3052-3054)GAA>CAA	p.E1018Q	CYFIP1_uc001yut.2_Missense_Mutation_p.E1018Q|CYFIP1_uc001yuu.2_Missense_Mutation_p.E587Q|CYFIP1_uc001yuv.2_Missense_Mutation_p.E212Q	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	1018					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GTCTTTAGAAGAAGTGTGTGA	0.527													98	170					0	0	0	0	C	22997806	C	C	22997806	3	2	26	1	0	0	0	0	1	0	0	0	4154	943	33	2	3535	2	CYFIP1	15	22997806	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08		22997806	79533586	210	5357											
OCA2	4948	broad.mit.edu	37	chr15	28211914	28211914	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcggaaagcagaccaggaGaacaaggcaaatcccaatga	18	2	12	9	1	0	3	0	1	0	2	1	6	1	4	2	3	3	2	2	3	5	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:28211914G>A	uc001zbh.3	-	15	1668	c.1558C>T	c.(1558-1560)CTC>TTC	p.L520F	OCA2_uc010ayv.2_Missense_Mutation_p.L496F	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	520	Helical; (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CAGACCAGGAGAACAAGGCAA	0.438									Oculocutaneous_Albinism				13	23					0	0	0	0	A	28211914	A	A	28211914	3	1	26	1	0	0	0	0	1	0	0	0	10869	942	33	2	998	2	OCA2	15	28211914	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	5214108	28211914	74319478	211	5358											
EIF2AK4	440275	broad.mit.edu	37	chr15	40268942	40268942	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggagtggagcacttcgggcGagcgctcggccagtgcccgt	5	7	17	12	5	0	0	0	0	0	0	2	3	0	2	2	4	3	2	2	4	0	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:40268942G>A	uc001zkm.1	+	12	2196	c.2146G>A	c.(2146-2148)GAG>AAG	p.E716K	EIF2AK4_uc010bbj.1_Missense_Mutation_p.E445K	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	716	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CACTTCGGGCGAGCGCTCGGC	0.716													36	62					0	0	0	0	A	40268942	A	A	40268942	3	1	26	1	0	0	0	0	1	0	0	0	5021	1059	37	1	2192	1	EIF2AK4	15	40268942	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	12057028	40268942	62262450	212	5359											
ZFP106	64397	broad.mit.edu	37	chr15	42743329	42743329	+	Silent	SNP	G	A	A																															caatcccgactgtaaatccaGagtcttctgagaagggtaag																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:42743329G>A	uc001zpw.2	-	2	1407	c.1072C>T	c.(1072-1074)CTG>TTG	p.L358L	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Silent_p.L141L|ZFP106_uc001zpy.1_Silent_p.L381L	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	358						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		TGTAAATCCAGAGTCTTCTGA	0.438													49	63					0	0	0	0	A	42743329	A	A	42743329	2	1	26	1	0	0	0	0	0	0	0	1	17704	933	33	2		2	ZFP106	15	42743329	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2474387	42743329	59788063	213	5360	10	2									
ZFP106	64397	broad.mit.edu	37	chr15	42743338	42743338	+	Missense_Mutation	SNP	G	C	C																															ctgtaaatccagagtcttctGagaagggtaaggcgtccagc																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:42743338G>C	uc001zpw.2	-	2	1398	c.1063C>G	c.(1063-1065)CAG>GAG	p.Q355E	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Missense_Mutation_p.Q138E|ZFP106_uc001zpy.1_Missense_Mutation_p.Q378E	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	355						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		AGAGTCTTCTGAGAAGGGTAA	0.448													49	60					0	0	0	0	C	42743338	C	C	42743338	3	2	26	1	0	0	0	0	1	0	0	0	17704	1299	45	2	4660	2	ZFP106	15	42743338	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	9	42743338	59788054	214	5361	10	2									
ZFP106	64397	broad.mit.edu	37	chr15	42743875	42743875	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccagaattactatggttgtGaaaccaagtcgaggagcctc	12	10	10	9	1	0	2	0	1	0	1	3	4	1	3	3	2	3	1	3	2	5	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:42743875G>C	uc001zpw.2	-	2	861	c.526C>G	c.(526-528)CAC>GAC	p.H176D	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_5'UTR|ZFP106_uc001zpy.1_Missense_Mutation_p.H199D	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	176						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		CTATGGTTGTGAAACCAAGTC	0.468													34	77					0	0	0	0	C	42743875	C	C	42743875	3	2	26	1	0	0	0	0	1	0	0	0	17704	1290	45	2	5197	2	ZFP106	15	42743875	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	537	42743875	59787517	215	5362											
SPG11	80208	broad.mit.edu	37	chr15	44856881	44856881	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaacaaaatcgtaggcctCagccacaatagaagccttaa	16	7	8	10	1	1	1	1	0	0	1	2	2	1	2	3	2	3	1	3	2	8	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:44856881C>T	uc001ztx.2	-	39	7046	c.7015G>A	c.(7015-7017)GAG>AAG	p.E2339K	SPG11_uc010bdw.2_Missense_Mutation_p.E469K|SPG11_uc010ueh.1_Missense_Mutation_p.E2226K|SPG11_uc010uei.1_Intron	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	2339	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TCGTAGGCCTCAGCCACAATA	0.373													27	38					0	0	0	0	T	44856881	T	T	44856881	3	4	26	1	0	0	0	0	1	0	0	0	15107	835	29	2	324	2	SPG11	15	44856881	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	2113006	44856881	57674511	216	5363											
AP4E1	23431	broad.mit.edu	37	chr15	51233943	51233943	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacaataattgaatgtttaGatcatcctgatcccattatt	13	16	5	7	0	1	4	1	3	0	1	3	4	3	4	2	0	0	1	2	0	5	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:51233943G>C	uc001zyx.1	+	10	1177	c.1147G>C	c.(1147-1149)GAT>CAT	p.D383H	AP4E1_uc010ufi.1_3'UTR|AP4E1_uc010ufj.1_RNA|AP4E1_uc010ufk.1_RNA|LOC100132724_uc010ufl.1_5'Flank	NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	383					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		TGAATGTTTAGATCATCCTGA	0.333													14	38					0	0	0	0	C	51233943	C	C	51233943	3	2	26	1	0	0	0	0	1	0	0	0	752	942	33	2	1185	2	AP4E1	15	51233943	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	6377062	51233943	51297449	217	5364											
VPS13C	54832	broad.mit.edu	37	chr15	62161820	62161820	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagctccttcctttttggCaccttcagaaaaccaatgac	11	11	6	13	0	1	2	1	1	0	1	3	2	3	2	4	1	3	3	4	1	3	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr15:62161820C>T	uc002agz.2	-	80	10701	c.10627G>A	c.(10627-10629)GCC>ACC	p.A3543T	VPS13C_uc002aha.2_Missense_Mutation_p.A3500T|VPS13C_uc002ahb.1_Missense_Mutation_p.A3543T|VPS13C_uc002ahc.1_Missense_Mutation_p.A3500T	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3543					protein localization					ovary(2)	2						TCCTTTTTGGCACCTTCAGAA	0.443													4	132					0	0	0	0	T	62161820	T	T	62161820	3	4	26	1	0	0	0	0	1	0	0	0	17259	710	25	4	686	4	VPS13C	15	62161820	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	10927877	62161820	40369572	218	5365											
HBZ	3050	broad.mit.edu	37	chr16	202962	202962	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtccatgtgggccaagatCtccacgcaggccgacaccat	9	7	11	14	2	1	1	0	0	1	1	3	2	2	1	5	2	0	1	5	2	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:202962C>T	uc002cft.1	+	1	109	c.54C>T	c.(52-54)ATC>ATT	p.I18I		NM_005332	NP_005323	P02008	HBAZ_HUMAN	hemoglobin, zeta	18						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		all_cancers(16;4.28e-07)|all_epithelial(16;2.09e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				GGGCCAAGATCTCCACGCAGG	0.622													17	36					0	0	0	0	T	202962	T	T	202962	2	4	26	1	0	0	0	0	0	0	0	1	7028	903	32	2		2	HBZ	16	202962	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08		202962	90151791	219	5366											
ITFG3	83986	broad.mit.edu	37	chr16	312520	312520	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgcactgggagagcatgctCaatgccaccacccgcaggat	10	5	11	15	2	1	1	1	0	0	1	1	3	1	2	4	2	3	4	4	2	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:312520C>G	uc002cgf.2	+	8	1134	c.939C>G	c.(937-939)CTC>CTG	p.L313L	ITFG3_uc010bqr.2_RNA|ITFG3_uc002cgg.2_Silent_p.L313L|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Silent_p.L313L	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	313	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				AGAGCATGCTCAATGCCACCA	0.652													25	38					0	0	0	0	G	312520	G	G	312520	2	3	26	1	0	0	0	0	0	0	0	1	7910	813	29	2		2	ITFG3	16	312520	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	109558	312520	90042233	220	5367											
BAIAP3	8938	broad.mit.edu	37	chr16	1388988	1388988	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gacagggcttgccgtgcctcGaggtaagggtgccaccccca	7	6	14	14	2	0	0	0	0	0	0	1	2	0	0	5	3	3	2	5	3	1	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:1388988G>C	uc002clk.1	+	3	322	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	BAIAP3_uc002clj.2_Missense_Mutation_p.E73Q|BAIAP3_uc010uuz.1_Missense_Mutation_p.E73Q|BAIAP3_uc010uva.1_Missense_Mutation_p.E73Q|BAIAP3_uc010uvb.1_Missense_Mutation_p.E108Q|BAIAP3_uc010uvc.1_Missense_Mutation_p.E73Q	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	108					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				GCCGTGCCTCGAGGTAAGGGT	0.667													40	66					0	0	0	0	C	1388988	C	C	1388988	3	2	26	1	0	0	0	0	1	0	0	0	1306	1059	37	3	332	3	BAIAP3	16	1388988	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1076468	1388988	88965765	221	5368											
HS3ST6	64711	broad.mit.edu	37	chr16	1961639	1961639	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctggtagaacctgcggttGaagggccggtagaactcctg	9	9	14	9	2	1	3	0	1	1	2	2	3	2	3	3	4	3	3	3	4	5	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:1961639G>A	uc002cnf.2	-	2	888	c.888C>T	c.(886-888)TTC>TTT	p.F296F		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	296											0						ACCTGCGGTTGAAGGGCCGGT	0.701													9	5					0	0	0	0	A	1961639	A	A	1961639	2	1	26	1	0	0	0	0	0	0	0	1	7408	1281	45	2		2	HS3ST6	16	1961639	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	572651	1961639	88393114	222	5369											
TNFRSF12A	51330	broad.mit.edu	37	chr16	3071626	3071626	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcgctctgagcctgaccttCgtgctggggctgctttctgg	2	12	15	12	2	2	2	0	2	2	0	3	2	2	2	2	4	3	4	2	4	0	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:3071626C>T	uc002csv.3	+	3	356	c.270C>T	c.(268-270)TTC>TTT	p.F90F	TNFRSF12A_uc002csw.3_Silent_p.F55F|THOC6_uc002ctb.2_5'Flank|THOC6_uc002ctd.2_5'Flank|THOC6_uc002ctc.2_5'Flank|THOC6_uc002cta.2_5'Flank	NM_016639	NP_057723	Q9NP84	TNR12_HUMAN	tumor necrosis factor receptor superfamily,	90	Helical; (Potential).				angiogenesis|apoptosis	integral to membrane	receptor activity				0						GCCTGACCTTCGTGCTGGGGC	0.652											OREG0023566	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	41					0	0	0	0	T	3071626	T	T	3071626	2	4	26	1	0	0	0	0	0	0	0	1	16352	883	31	1		1	TNFRSF12A	16	3071626	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1109987	3071626	87283127	223	5370											
GRIN2A	2903	broad.mit.edu	37	chr16	9857426	9857426	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggacactaaacaggctgccGtaaaaatttccctccagaag	14	7	9	11	1	0	1	0	0	0	1	2	2	2	2	3	2	2	2	3	2	6	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:9857426G>A	uc002czo.3	-	13	4523	c.3975C>T	c.(3973-3975)TAC>TAT	p.Y1325Y	GRIN2A_uc010uym.1_Silent_p.Y1325Y|GRIN2A_uc010uyn.1_Intron|GRIN2A_uc002czr.3_Intron	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1325	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACAGGCTGCCGTAAAAATTTC	0.527													56	86					0	0	0	0	A	9857426	A	A	9857426	2	1	26	1	0	0	0	0	0	0	0	1	6818	1140	40	1		1	GRIN2A	16	9857426	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	6785800	9857426	80497327	224	5371											
ACSM1	116285	broad.mit.edu	37	chr16	20696551	20696551	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagccaccagccaccactCaggaactcgaggcagcatca	13	3	8	17	1	2	0	2	0	0	0	3	2	2	1	4	2	4	2	4	2	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:20696551C>G	uc002dhm.1	-	2	435	c.367G>C	c.(367-369)GAG>CAG	p.E123Q	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Missense_Mutation_p.E123Q	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	123					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						AGCCACCACTCAGGAACTCGA	0.582													22	74					0	0	0	0	G	20696551	G	G	20696551	3	3	26	1	0	0	0	0	1	0	0	0	182	835	29	2	1414	2	ACSM1	16	20696551	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	10839125	20696551	69658202	225	5372											
HIRIP3	8479	broad.mit.edu	37	chr16	30005773	30005773	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgctctttcttctgggctagGatctcctcttcactctcctg	3	17	7	14	0	7	0	1	0	6	0	9	1	7	1	2	2	1	2	2	2	1	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:30005773G>A	uc002dve.2	-	4	1154	c.693C>T	c.(691-693)ATC>ATT	p.I231I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvg.1_5'Flank|INO80E_uc002dvh.1_5'Flank|INO80E_uc002dvi.1_5'Flank|INO80E_uc002dvj.1_5'Flank|INO80E_uc002dvk.1_5'Flank|HIRIP3_uc002dvf.2_Intron	NM_003609	NP_003600	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	231	Glu-rich.				chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)	1						TCTGGGCTAGGATCTCCTCTT	0.368													6	230					0	0	0	0	A	30005773	A	A	30005773	2	1	26	1	0	0	0	0	0	0	0	1	7160	1164	41	2		2	HIRIP3	16	30005773	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	9309222	30005773	60348980	226	5373											
PRSS36	146547	broad.mit.edu	37	chr16	31153248	31153248	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agccagaaaccaggtcccctCctcctggcacaaaaggctcc	11	5	8	17	0	0	1	0	0	0	1	4	1	4	1	7	3	2	2	7	3	3	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:31153248C>G	uc002ebd.2	-	11	1614	c.1555G>C	c.(1555-1557)GAG>CAG	p.E519Q	PRSS36_uc010vff.1_Missense_Mutation_p.E294Q|PRSS36_uc010vfg.1_Missense_Mutation_p.E514Q|PRSS36_uc010vfh.1_Missense_Mutation_p.E519Q	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	519	Peptidase S1 2.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						CAGGTCCCCTCCTCCTGGCAC	0.557													46	89					0	0	0	0	G	31153248	G	G	31153248	3	3	26	1	0	0	0	0	1	0	0	0	12687	864	30	2	1032	2	PRSS36	16	31153248	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1147475	31153248	59201505	227	5374											
CHD9	80205	broad.mit.edu	37	chr16	53260306	53260306	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaaatcgacaaattaaaaGaaaaaaatacgcagaagata	25	6	5	5	2	1	3	1	0	0	3	2	4	1	3	0	0	1	1	0	0	10	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:53260306G>C	uc002ehb.2	+	4	2089	c.1925G>C	c.(1924-1926)AGA>ACA	p.R642T	CHD9_uc002egy.2_Missense_Mutation_p.R642T|CHD9_uc002egz.1_Missense_Mutation_p.R642T|CHD9_uc002eha.1_Missense_Mutation_p.R642T|CHD9_uc002ehc.2_Missense_Mutation_p.R642T|CHD9_uc002ehd.2_Missense_Mutation_p.R168T	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	642	Lys-rich.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CAAATTAAAAGAAAAAAATAC	0.289													16	24					0	0	0	0	C	53260306	C	C	53260306	3	2	26	1	0	0	0	0	1	0	0	0	3347	942	33	2	1939	2	CHD9	16	53260306	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	22107058	53260306	37094447	228	5375											
FTO	79068	broad.mit.edu	37	chr16	53844097	53844097	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagacacttggctcccttatCtgacccccaaagatgatgaa	13	9	7	12	0	1	5	0	3	1	2	2	5	2	5	3	1	0	1	3	1	4	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:53844097C>G	uc002ehr.2	+	2	313	c.91C>G	c.(91-93)CTG>GTG	p.L31V	FTO_uc010vha.1_Translation_Start_Site	NM_001080432	NP_001073901	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	31					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GCTCCCTTATCTGACCCCCAA	0.264													21	43					0	0	0	0	G	53844097	G	G	53844097	3	3	26	1	0	0	0	0	1	0	0	0	6120	912	32	2	97	2	FTO	16	53844097	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	583791	53844097	36510656	229	5376											
LRRC36	55282	broad.mit.edu	37	chr16	67405001	67405001	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaactcctctgcggacactGctgttgtctcctgggacttc	6	12	9	14	1	2	0	0	0	2	0	5	2	3	2	2	2	3	2	2	2	1	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:67405001G>A	uc002esv.2	+	9	1369	c.1350G>A	c.(1348-1350)CTG>CTA	p.L450L	LRRC36_uc002esw.2_RNA|LRRC36_uc010ceh.2_Silent_p.L182L|LRRC36_uc002esx.2_Silent_p.L329L|LRRC36_uc010vjk.1_Silent_p.L329L|LRRC36_uc010vjl.1_5'UTR|LRRC36_uc002esy.2_Intron	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	450											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		TGCGGACACTGCTGTTGTCTC	0.468													44	70					0	0	0	0	A	67405001	A	A	67405001	2	1	26	1	0	0	0	0	0	0	0	1	9040	1306	46	4		4	LRRC36	16	67405001	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	13560904	67405001	22949752	230	5377											
GFOD2	81577	broad.mit.edu	37	chr16	67709325	67709325	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtacagcagcgggacatcCtggggcccctgctcaggcag	8	5	15	13	1	1	0	1	0	0	0	2	1	2	1	3	5	4	4	3	5	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:67709325C>G	uc002eub.2	-	3	1186	c.891G>C	c.(889-891)CAG>CAC	p.Q297H	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Missense_Mutation_p.Q192H	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	297						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		GCGGGACATCCTGGGGCCCCT	0.667													5	74					0	0	0	0	G	67709325	G	G	67709325	3	3	26	1	0	0	0	0	1	0	0	0	6381	680	24	4	270	4	GFOD2	16	67709325	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	304324	67709325	22645428	231	5378											
NRN1L	123904	broad.mit.edu	37	chr16	67920047	67920047	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcgggagcgcggcacaggctCcgaaaccaaccaggagacgc	11	2	14	14	5	0	1	0	0	0	1	2	4	1	2	3	4	3	2	3	4	2	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:67920047C>G	uc002euu.2	+	3	409	c.383C>G	c.(382-384)TCC>TGC	p.S128C	EDC4_uc002eut.1_3'UTR	NM_198443	NP_940845	Q496H8	NRN1L_HUMAN	neuritin 1-like precursor	128						anchored to membrane|plasma membrane				central_nervous_system(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		GGCACAGGCTCCGAAACCAAC	0.667													4	17					0	0	0	0	G	67920047	G	G	67920047	3	3	26	1	0	0	0	0	1	0	0	0	10713	855	30	2	393	2	NRN1L	16	67920047	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	210722	67920047	22434706	232	5379											
DPEP2	64174	broad.mit.edu	37	chr16	68025794	68025794	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagcgcactcccagcatgtaGaaggtaggtaagatggagag	13	7	14	7	1	0	3	0	0	0	3	1	4	1	3	1	3	2	5	1	3	5	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:68025794G>C	uc010cey.2	-	4	773	c.609C>G	c.(607-609)TTC>TTG	p.F203L	DPEP2_uc002evd.3_Missense_Mutation_p.F203L|DPEP2_uc002eve.2_Missense_Mutation_p.F203L|DPEP2_uc002evf.2_RNA|DPEP2_uc002evg.2_3'UTR	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	dipeptidase 2 precursor	203					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		CCAGCATGTAGAAGGTAGGTA	0.592													28	58					0	0	0	0	C	68025794	C	C	68025794	3	2	26	1	0	0	0	0	1	0	0	0	4736	933	33	2	879	2	DPEP2	16	68025794	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	105747	68025794	22328959	233	5380											
DUS2L	54920	broad.mit.edu	37	chr16	68109341	68109341	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggctctcagccaagacttCagagcagacaggggagccag	12	4	13	12	0	2	3	2	0	1	3	3	4	2	4	2	3	3	2	2	3	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:68109341C>T	uc002evi.2	+	14	1165	c.1016C>T	c.(1015-1017)TCA>TTA	p.S339L	DUS2L_uc002evj.2_Missense_Mutation_p.S339L|DUS2L_uc010vkk.1_Missense_Mutation_p.S304L|DUS2L_uc010cez.2_Missense_Mutation_p.S252L	NM_017803	NP_060273	Q9NX74	DUS2L_HUMAN	dihydrouridine synthase 2-like, SMM1 homolog	339					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		GCCAAGACTTCAGAGCAGACA	0.567													20	32					0	0	0	0	T	68109341	T	T	68109341	3	4	26	1	0	0	0	0	1	0	0	0	4828	838	29	2	1062	2	DUS2L	16	68109341	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	83547	68109341	22245412	234	5381											
PLA2G15	23659	broad.mit.edu	37	chr16	68293433	68293433	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgaagagtgccctgcagtGccaggcctggcagagccgcc	7	6	14	14	1	0	3	0	1	0	2	0	3	0	3	5	2	4	2	5	2	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:68293433G>T	uc002evr.2	+	6	1195	c.1112G>T	c.(1111-1113)TGC>TTC	p.C371F	PLA2G15_uc010vld.1_3'UTR|PLA2G15_uc010vle.1_Missense_Mutation_p.C277F|PLA2G15_uc010vlf.1_Missense_Mutation_p.C171F|PLA2G15_uc002evs.2_Missense_Mutation_p.C192F	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	lysophospholipase 3 (lysosomal phospholipase A2)	371					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			ovary(1)	1						GCCCTGCAGTGCCAGGCCTGG	0.587													21	40					2.89027e-11	3.03891e-11	1	0	T	68293433	T	T	68293433	3	4	26	1	0	0	0	0	1	0	0	0	12047	1319	46	4	1134	4	PLA2G15	16	68293433	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	184092	68293433	22061320	235	5382											
ZFHX3	463	broad.mit.edu	37	chr16	72993190	72993190	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaaaggagagtttgcacaaGaaacacatcaggatgggctt	15	7	11	8	0	1	2	1	0	0	2	1	4	1	3	1	3	2	3	1	3	3	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:72993190G>C	uc002fck.2	-	2	1528	c.855C>G	c.(853-855)TTC>TTG	p.F285L	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	285	C2H2-type 1.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GTTTGCACAAGAAACACATCA	0.498													36	80					0	0	0	0	C	72993190	C	C	72993190	3	2	26	1	0	0	0	0	1	0	0	0	17701	933	33	2	10292	2	ZFHX3	16	72993190	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	4699757	72993190	17361563	236	5383											
LRRC50	123872	broad.mit.edu	37	chr16	84209596	84209596	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagtgatgacagtgaccctGaactggactacacgtcactc	11	9	10	11	1	1	5	1	5	0	0	2	6	1	6	1	1	2	0	1	1	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:84209596G>A	uc002fhl.3	+	11	1937	c.1756G>A	c.(1756-1758)GAA>AAA	p.E586K	LRRC50_uc010vnw.1_Missense_Mutation_p.E350K	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	586					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						CAGTGACCCTGAACTGGACTA	0.453									Kartagener_syndrome		OREG0023983	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	69					0	0	0	0	A	84209596	A	A	84209596	3	1	26	1	0	0	0	0	1	0	0	0	9059	1291	45	2	1798	2	LRRC50	16	84209596	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	11216406	84209596	6145157	237	5384											
ANKRD11	29123	broad.mit.edu	37	chr16	89349254	89349254	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagcttctgtttatttttCttatcttgcgtggagtccac	5	18	10	8	1	3	0	0	0	3	0	4	2	4	2	1	2	2	2	1	2	2	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:89349254C>G	uc002fmx.1	-	9	4157	c.3696G>C	c.(3694-3696)AAG>AAC	p.K1232N	ANKRD11_uc002fmy.1_Missense_Mutation_p.K1232N|ANKRD11_uc002fnc.1_Missense_Mutation_p.K1232N|ANKRD11_uc002fnb.1_Missense_Mutation_p.K1189N	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1232	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GTTTATTTTTCTTATCTTGCG	0.443													58	57					0	0	0	0	G	89349254	G	G	89349254	3	3	26	1	0	0	0	0	1	0	0	0	639	912	32	2	4315	2	ANKRD11	16	89349254	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	5139658	89349254	1005499	238	5385											
ANKRD11	29123	broad.mit.edu	37	chr16	89349405	89349405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcggtcctttctcctgtctCtgggctccttgtccttctgc	0	17	8	16	1	3	0	0	0	3	0	9	0	6	0	4	2	1	1	4	2	0	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr16:89349405C>T	uc002fmx.1	-	9	4006	c.3545G>A	c.(3544-3546)AGA>AAA	p.R1182K	ANKRD11_uc002fmy.1_Missense_Mutation_p.R1182K|ANKRD11_uc002fnc.1_Missense_Mutation_p.R1182K|ANKRD11_uc002fnb.1_Missense_Mutation_p.R1139K	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1182	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCTCCTGTCTCTGGGCTCCTT	0.542													58	79					0	0	0	0	T	89349405	T	T	89349405	3	4	26	1	0	0	0	0	1	0	0	0	639	913	32	2	4466	2	ANKRD11	16	89349405	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	151	89349405	1005348	239	5386											
WDR81	124997	broad.mit.edu	37	chr17	1636853	1636853	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggaaaatcatccccaaccacGagctggttggggagctggcg	10	6	14	11	2	1	0	1	0	0	0	2	3	2	2	3	5	3	3	3	5	3	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:1636853G>C	uc002fti.2	+	7	1102	c.841G>C	c.(841-843)GAG>CAG	p.E281Q	WDR81_uc002fth.2_Missense_Mutation_p.E457Q|WDR81_uc010vqp.1_Missense_Mutation_p.E305Q|WDR81_uc002ftj.2_Missense_Mutation_p.E1508Q|WDR81_uc010vqq.1_Missense_Mutation_p.E139Q	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	281										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCCCAACCACGAGCTGGTTGG	0.632													75	122					0	0	0	0	C	1636853	C	C	1636853	3	2	26	1	0	0	0	0	1	0	0	0	17398	1059	37	3	4610	3	WDR81	17	1636853	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08		1636853	79558357	240	5387											
OR1G1	8390	broad.mit.edu	37	chr17	3030534	3030534	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagcatcacaaataacatGaaaaaatacaactgtagtag	20	8	5	8	0	1	1	1	1	0	0	2	1	2	1	1	0	4	3	1	0	9	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:3030534G>T	uc002fvc.1	-	1	312	c.312C>A	c.(310-312)TTC>TTA	p.F104L		NM_003555	NP_003546	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAAATAACATGAAAAAATACA	0.483													10	82					0.000442599	0.000449935	1	0	T	3030534	T	T	3030534	3	4	26	1	0	0	0	0	1	0	0	0	11011	1281	45	2	633	2	OR1G1	17	3030534	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1393681	3030534	78164676	241	5388											
OR1A2	26189	broad.mit.edu	37	chr17	3101343	3101343	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccaggaagtagccaatttCtactgtgacattatgccttt	12	13	7	9	0	1	1	0	1	1	0	1	2	1	2	3	1	4	1	3	1	6	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:3101343C>T	uc002fvd.1	+	1	531	c.531C>T	c.(529-531)TTC>TTT	p.F177F		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TAGCCAATTTCTACTGTGACA	0.473													57	93					0	0	0	0	T	3101343	T	T	3101343	2	4	26	1	0	0	0	0	0	0	0	1	11004	912	32	2		2	OR1A2	17	3101343	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	70809	3101343	78093867	242	5389											
TRPV1	7442	broad.mit.edu	37	chr17	3495380	3495380	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggcaccggtggggccgtCtcctggcctctggatggtga	3	9	16	13	2	2	1	0	1	2	0	3	2	2	2	5	7	0	1	5	7	0	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:3495380C>G	uc010vrr.1	-	1	792	c.265G>C	c.(265-267)GAC>CAC	p.D89H	TRPV1_uc010vro.1_Missense_Mutation_p.D89H|TRPV1_uc010vrp.1_Missense_Mutation_p.D89H|TRPV1_uc010vrq.1_Missense_Mutation_p.E63D|TRPV1_uc010vrs.1_Missense_Mutation_p.D89H|TRPV1_uc010vrt.1_Missense_Mutation_p.D89H|TRPV1_uc010vru.1_Missense_Mutation_p.D89H	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,	89	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	GTGGGGCCGTCTCCTGGCCTC	0.657													12	43					0	0	0	0	G	3495380	G	G	3495380	3	3	26	1	0	0	0	0	1	0	0	0	16662	913	32	2	1987	2	TRPV1	17	3495380	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	394037	3495380	77699830	243	5390											
TRPV1	7442	broad.mit.edu	37	chr17	3495440	3495440	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtcgggcaggagtccagctCaccttcctcgtgagggcaat	7	8	14	12	2	1	1	1	1	0	0	5	2	3	2	3	4	1	3	3	4	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:3495440C>G	uc010vrr.1	-	1	732	c.205G>C	c.(205-207)GAG>CAG	p.E69Q	TRPV1_uc010vro.1_Missense_Mutation_p.E69Q|TRPV1_uc010vrp.1_Missense_Mutation_p.E69Q|TRPV1_uc010vrq.1_Silent_p.V43V|TRPV1_uc010vrs.1_Missense_Mutation_p.E69Q|TRPV1_uc010vrt.1_Missense_Mutation_p.E69Q|TRPV1_uc010vru.1_Missense_Mutation_p.E69Q	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,	69	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	GAGTCCAGCTCACCTTCCTCG	0.652													13	25					0	0	0	0	G	3495440	G	G	3495440	3	3	26	1	0	0	0	0	1	0	0	0	16662	835	29	2	2047	2	TRPV1	17	3495440	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	60	3495440	77699770	244	5391											
TP53	7157	broad.mit.edu	37	chr17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcaccaccacactatgtcGaaaagtgtttctgtcatcca	11	10	8	12	1	2	0	1	0	1	0	4	1	3	0	3	1	0	2	3	1	3	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	8					0	0	0	0	A	7578212	A	A	7578212	4	1	26	1	0	0	0	0	0	1	0	0	16448	1066	37	1	657	1	TP53	17	7578212	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	4082772	7578212	73616998	245	5392											
DNAH2	146754	broad.mit.edu	37	chr17	7623114	7623114	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaagctcccaggcaagctGgtcagggcgggccactcggg	8	4	17	12	2	1	0	1	0	0	0	3	1	2	1	2	6	2	3	2	6	2	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:7623114G>A	uc002giu.1	+	1	76	c.62G>A	c.(61-63)TGG>TAG	p.W21*	DNAH2_uc002git.2_Nonsense_Mutation_p.W21*|DNAH2_uc010vuk.1_Nonsense_Mutation_p.W21*	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	21	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAGGCAAGCTGGTCAGGGCGG	0.617													18	24					0	0	0	0	A	7623114	A	A	7623114	4	1	26	1	0	0	0	0	0	1	0	0	4624	1357	47	4	64	4	DNAH2	17	7623114	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	44902	7623114	73572096	246	5393											
MYH10	4628	broad.mit.edu	37	chr17	8415820	8415822	+	In_Frame_Del	DEL	TTC	-	-																															ttttggaggatttggtttctTtcttcttcttcttcaaccct																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:8415820_8415822delTTC	uc002gll.2	-	22	2902_2904	c.2806_2808delGAA	c.(2806-2808)GAAdel	p.E936del	MYH10_uc002glm.2_In_Frame_Del_p.E967del|MYH10_uc010cnx.2_In_Frame_Del_p.E945del	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	936	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TTTGGTTTCTTTCTTCTTCTTCT	0.35													---	---	---								-	8415822	-	-	8415820	7	5	26	1	0	1	0	1	0	0	0	0	10083	1838	64	0	3202	0	MYH10	17	8415820	In_Frame_Del	DEL	TTC	TCGA-BB-4227-01A-01D-1870-08	792706	8415820	72779390	247	5394											
TNFAIP1	7126	broad.mit.edu	37	chr17	26666552	26666552	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctacctgcagcgggagatgtCgggggacacctgcctgtgcc	6	7	15	13	2	0	1	0	0	0	1	1	3	0	2	4	3	5	1	4	3	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:26666552C>T	uc002hax.1	+	2	24	c.5C>T	c.(4-6)TCG>TTG	p.S2L	TNFAIP1_uc002hay.2_Missense_Mutation_p.S2L|TNFAIP1_uc010waf.1_Intron	NM_021137	NP_066960	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1	2					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CGGGAGATGTCGGGGGACACC	0.637													17	31					0	0	0	0	T	26666552	T	T	26666552	3	4	26	1	0	0	0	0	1	0	0	0	16338	893	31	1	7	1	TNFAIP1	17	26666552	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	18250732	26666552	54528658	248	5395											
PIGS	94005	broad.mit.edu	37	chr17	26897883	26897883	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactcacatttcagaggaatCtctctttcatgcacaacggt	12	12	6	11	1	5	1	3	0	2	1	6	2	5	2	0	2	3	1	0	2	3	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:26897883C>T	uc002hbo.2	-	3	646	c.273G>A	c.(271-273)GAG>GAA	p.E91E	PIGS_uc002hbn.2_Silent_p.E83E|PIGS_uc010wap.1_Silent_p.E30E	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	91	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					TCAGAGGAATCTCTCTTTCAT	0.562													5	134					0	0	0	0	T	26897883	T	T	26897883	2	4	26	1	0	0	0	0	0	0	0	1	11953	912	32	2		2	PIGS	17	26897883	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	231331	26897883	54297327	249	5396											
KIAA0100	9703	broad.mit.edu	37	chr17	26965349	26965349	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtggcgcccgctgaatgtggGagtcactgcccacacgccag	7	6	14	14	3	1	1	1	1	0	0	1	2	1	2	3	2	1	1	3	2	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:26965349G>A	uc002hbu.2	-	13	1532	c.1433C>T	c.(1432-1434)TCC>TTC	p.S478F		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	478						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CTGAATGTGGGAGTCACTGCC	0.562													28	42					0	0	0	0	A	26965349	A	A	26965349	3	1	26	1	0	0	0	0	1	0	0	0	8193	1174	41	2	5382	2	KIAA0100	17	26965349	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	67466	26965349	54229861	250	5397											
NUFIP2	57532	broad.mit.edu	37	chr17	27613310	27613310	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttgaggactagtccgtttctCcagctcgtaagccttgggaa	8	12	11	10	2	1	1	0	1	1	0	4	3	2	3	3	2	2	3	3	2	3	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:27613310C>G	uc002hdy.3	-	2	1791	c.1702G>C	c.(1702-1704)GAG>CAG	p.E568Q	NUFIP2_uc002hdx.3_Intron	NM_020772	NP_065823	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein	568						nucleus|polysomal ribosome	protein binding|RNA binding			skin(2)|ovary(1)|breast(1)	4			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			GTCCGTTTCTCCAGCTCGTAA	0.463													12	84					0	0	0	0	G	27613310	G	G	27613310	3	3	26	1	0	0	0	0	1	0	0	0	10803	864	30	2	397	2	NUFIP2	17	27613310	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	647961	27613310	53581900	251	5398											
EVI2B	2124	broad.mit.edu	37	chr17	29632227	29632227	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actttggtggttgtgtggtaGaagtacgggcagatggtagt	8	13	17	3	1	0	2	0	0	0	2	0	2	0	2	0	5	1	5	0	5	4	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:29632227G>C	uc002hgk.2	-	2	556	c.401C>G	c.(400-402)TCT>TGT	p.S134C	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.S149C	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	134	Extracellular (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		TTGTGTGGTAGAAGTACGGGC	0.448													127	216					0	0	0	0	C	29632227	C	C	29632227	3	2	26	1	0	0	0	0	1	0	0	0	5312	942	33	2	949	2	EVI2B	17	29632227	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2018917	29632227	51562983	252	5399											
MED1	5469	broad.mit.edu	37	chr17	37564043	37564043	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgtctgagctgggactattCtgataagatttctctgctat	8	16	9	8	1	3	3	0	2	3	1	5	4	3	4	0	1	2	2	0	1	3	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:37564043C>T	uc002hrv.3	-	17	4643	c.4431G>A	c.(4429-4431)CAG>CAA	p.Q1477Q	MED1_uc010wee.1_Silent_p.Q1305Q|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1477	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TGGGACTATTCTGATAAGATT	0.438										HNSCC(31;0.082)			27	95					0	0	0	0	T	37564043	T	T	37564043	2	4	26	1	0	0	0	0	0	0	0	1	9478	912	32	2		2	MED1	17	37564043	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	7931816	37564043	43631167	253	5400											
KRT27	342574	broad.mit.edu	37	chr17	38935781	38935781	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagagggactgaagttcaatCtcaagggtttgaagagtgcg	13	9	14	5	1	2	4	2	2	1	2	3	5	2	5	0	2	1	2	0	2	5	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:38935781C>T	uc002hvg.2	-	5	986	c.945G>A	c.(943-945)GAG>GAA	p.E315E		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	315	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				GAAGTTCAATCTCAAGGGTTT	0.453													25	255					0	0	0	0	T	38935781	T	T	38935781	2	4	26	1	0	0	0	0	0	0	0	1	8503	912	32	2		2	KRT27	17	38935781	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1371738	38935781	42259429	254	5401											
KRT39	390792	broad.mit.edu	37	chr17	39118663	39118663	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatcccccacctgcgtgttGaaccactgttccacatcttt	8	13	5	15	1	1	1	0	1	1	0	3	1	3	1	5	0	2	2	5	0	2	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:39118663G>C	uc002hvo.1	-	4	897	c.861C>G	c.(859-861)TTC>TTG	p.F287L	KRT39_uc010wfm.1_Missense_Mutation_p.F20L	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	287	Coil 2.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				CCTGCGTGTTGAACCACTGTT	0.433													82	862					0	0	0	0	C	39118663	C	C	39118663	3	2	26	1	0	0	0	0	1	0	0	0	8515	1281	45	2	630	2	KRT39	17	39118663	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	182882	39118663	42076547	255	5402											
AKAP1	8165	broad.mit.edu	37	chr17	55183460	55183460	+	Frame_Shift_Del	DEL	A	-	-																															tggtgatgccgtgttgggggAaaaggtgcttgaagaagctc																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:55183460delA	uc002iux.2	+	2	866	c.635delA	c.(634-636)GAAfs	p.E212fs	AKAP1_uc010wnl.1_Frame_Shift_Del_p.E212fs|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Frame_Shift_Del_p.E212fs	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	212					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					GTGTTGGGGGAAAAGGTGCTT	0.587													---	---	---								-	55183460	-	-	55183460	7	5	26	1	0	1	0	1	0	0	0	0	445	246	9	0	637	0	AKAP1	17	55183460	Frame_Shift_Del	DEL	A	TCGA-BB-4227-01A-01D-1870-08	16064797	55183460	26011750	256	5403											
NUP85	79902	broad.mit.edu	37	chr17	73227442	73227442	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgaatctgcagcatcgccCtgagcaactggtggtttgtg	7	12	12	10	1	2	2	0	2	2	0	3	2	2	2	1	2	4	4	1	2	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr17:73227442C>T	uc002jng.1	+	12	1362	c.1102C>T	c.(1102-1104)CTG>TTG	p.L368L	NUP85_uc010dgd.1_Silent_p.L323L|NUP85_uc010wrv.1_Silent_p.L322L|NUP85_uc002jnh.1_5'UTR	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	368					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			CAGCATCGCCCTGAGCAACTG	0.582													5	191					0	0	0	0	T	73227442	T	T	73227442	2	4	26	1	0	0	0	0	0	0	0	1	10824	680	24	4		4	NUP85	17	73227442	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	18043982	73227442	7967768	257	5404											
LRRC30	339291	broad.mit.edu	37	chr18	7231387	7231387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgtctcacaaccagctccGggttctccctcccgaggtgg	5	10	10	16	2	3	0	1	0	3	0	7	1	5	0	4	3	2	2	4	3	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr18:7231387G>A	uc010wzk.1	+	1	251	c.251G>A	c.(250-252)CGG>CAG	p.R84Q		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	84	LRR 1.									ovary(1)|liver(1)	2						AACCAGCTCCGGGTTCTCCCT	0.587													23	45					0	0	0	0	A	7231387	A	A	7231387	3	1	26	1	0	0	0	0	1	0	0	0	9035	1116	39	1	253	1	LRRC30	18	7231387	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08		7231387	70845861	258	5405											
RBBP8	5932	broad.mit.edu	37	chr18	20562197	20562197	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaggaatgatcaacagcatCaagcagctgagcttgaatgt	14	9	10	8	0	2	3	2	3	0	0	2	4	2	4	0	1	5	4	0	1	5	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr18:20562197C>G	uc002ktw.2	+	7	776	c.445C>G	c.(445-447)CAA>GAA	p.Q149E	RBBP8_uc002kty.2_Missense_Mutation_p.Q149E|RBBP8_uc002ktz.2_Missense_Mutation_p.Q149E|RBBP8_uc002kua.2_Missense_Mutation_p.Q149E|RBBP8_uc002ktx.1_Missense_Mutation_p.Q149E	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	149	Potential.				cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			TCAACAGCATCAAGCAGCTGA	0.403								Direct_reversal_of_damage|Homologous_recombination					15	21					0	0	0	0	G	20562197	G	G	20562197	3	3	26	1	0	0	0	0	1	0	0	0	13170	827	29	2	467	2	RBBP8	18	20562197	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	13330810	20562197	57515051	259	5406											
PARD6G	84552	broad.mit.edu	37	chr18	77960666	77960666	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaagttgtcatcattgttGatgggcagcaggtctccgtg	8	12	13	8	1	3	2	2	1	1	1	4	2	3	2	1	2	1	4	1	2	1	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr18:77960666G>A	uc002lny.2	-	2	388	c.222C>T	c.(220-222)ATC>ATT	p.I74I	PARD6G_uc010xfp.1_Silent_p.I74I	NM_032510	NP_115899	Q9BYG4	PAR6G_HUMAN	PAR-6 gamma protein	74	OPR.				cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding				0		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)		CATCATTGTTGATGGGCAGCA	0.493													6	108					0	0	0	0	A	77960666	A	A	77960666	2	1	26	1	0	0	0	0	0	0	0	1	11501	1280	45	2		2	PARD6G	18	77960666	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	57398469	77960666	116582	260	5407											
ABCA7	10347	broad.mit.edu	37	chr19	1055346	1055346	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctacccgcgcctggtgcgcCaggggtgagccatgccctgg	4	6	15	16	3	0	1	0	1	0	0	0	1	0	1	6	4	4	0	6	4	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:1055346C>T	uc002lqw.3	+	30	4432	c.4201C>T	c.(4201-4203)CAG>TAG	p.Q1401*	ABCA7_uc010dsb.1_Nonsense_Mutation_p.Q1263*|ABCA7_uc002lqy.2_5'Flank	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1401	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGGTGCGCCAGGGGTGAGC	0.637													5	18					0	0	0	0	T	1055346	T	T	1055346	4	4	26	1	0	0	0	0	0	1	0	0	37	595	21	4	4315	4	ABCA7	19	1055346	Nonsense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08		1055346	58073637	261	5408											
C19orf28	126321	broad.mit.edu	37	chr19	3542796	3542796	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcctagtgggtcccccagtCttccctgggccatggcttag	4	10	13	14	0	1	0	0	0	1	0	3	0	3	0	5	4	0	1	5	4	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:3542796C>G	uc002lxw.2	-	10	1770	c.1600G>C	c.(1600-1602)GAC>CAC	p.D534H	C19orf28_uc002lxx.2_Intron|C19orf28_uc010dtl.1_5'Flank|C19orf71_uc010xhm.1_Intron	NM_021731	NP_068377	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform a	Error:Variant_position_missing_in_Q6NUT3_after_alignment					transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCCCCCAGTCTTCCCTGGGC	0.368													11	19					0	0	0	0	G	3542796	G	G	3542796	3	3	26	1	0	0	0	0	1	0	0	0	1926	913	32	2	26	2	C19orf28	19	3542796	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	2487450	3542796	55586187	262	5409											
ZNF559	84527	broad.mit.edu	37	chr19	9453221	9453221	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggaaagcttttgctaactCttcacatcttactgtacata	11	15	6	9	0	3	0	1	0	2	0	3	1	3	1	0	1	5	3	0	1	5	7			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:9453221C>G	uc002mlg.2	+	7	1741	c.1094C>G	c.(1093-1095)TCT>TGT	p.S365C	ZNF559_uc002mlf.2_Missense_Mutation_p.S134C|ZNF559_uc010dwl.1_Missense_Mutation_p.S134C|ZNF559_uc010xkn.1_Missense_Mutation_p.S357C|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Missense_Mutation_p.S429C|ZNF559_uc010dwk.1_Missense_Mutation_p.S134C|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	365	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTTGCTAACTCTTCACATCTT	0.378													13	23					0	0	0	0	G	9453221	G	G	9453221	3	3	26	1	0	0	0	0	1	0	0	0	18057	913	32	2	1108	2	ZNF559	19	9453221	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	5910425	9453221	49675762	263	5410											
TYK2	7297	broad.mit.edu	37	chr19	10469922	10469922	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	catgggcacatggccccgctCcctccgcagccacacatcca	8	5	8	20	2	0	0	0	0	0	0	3	0	3	0	6	2	1	3	6	2	0	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:10469922C>G	uc002moc.3	-	15	2482	c.2104G>C	c.(2104-2106)GAG>CAG	p.E702Q	TYK2_uc010dxe.2_Missense_Mutation_p.E517Q|TYK2_uc002mod.2_Missense_Mutation_p.E702Q	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	702	Protein kinase 1.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			TGGCCCCGCTCCCTCCGCAGC	0.637													3	32					0	0	0	0	G	10469922	G	G	10469922	3	3	26	1	0	0	0	0	1	0	0	0	16878	864	30	2	1503	2	TYK2	19	10469922	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1016701	10469922	48659061	264	5411											
PLVAP	83483	broad.mit.edu	37	chr19	17487789	17487789	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaggtcgcggcgagcattCagccacatctgcatgatggc	8	8	12	13	3	2	1	1	1	1	0	4	2	3	1	2	3	3	2	2	3	0	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:17487789C>G	uc002ngk.1	-	1	359	c.309G>C	c.(307-309)CTG>CTC	p.L103L		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	103	Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						GGCGAGCATTCAGCCACATCT	0.547													10	59					0	0	0	0	G	17487789	G	G	17487789	2	3	26	1	0	0	0	0	0	0	0	1	12171	813	29	2		2	PLVAP	19	17487789	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	7017867	17487789	41641194	265	5412											
NCAN	1463	broad.mit.edu	37	chr19	19356217	19356217	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgaaagcgggcgctggaaCgatgtcccctgcaactacaa	12	6	11	12	3	0	1	0	1	0	0	1	3	1	2	2	2	5	2	2	2	5	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:19356217C>T	uc002nlz.2	+	13	3687	c.3588C>T	c.(3586-3588)AAC>AAT	p.N1196N	NCAN_uc002nma.2_Intron	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1196	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GGCGCTGGAACGATGTCCCCT	0.552													21	56					0	0	0	0	T	19356217	T	T	19356217	2	4	26	1	0	0	0	0	0	0	0	1	10258	535	19	1		1	NCAN	19	19356217	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1868428	19356217	39772766	266	5413											
CAPN12	147968	broad.mit.edu	37	chr19	39234625	39234625	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgagtccggccccagctggtCatagccaagggcatcagggc	8	5	14	14	2	2	0	2	0	0	0	3	1	3	0	4	4	2	2	4	4	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:39234625C>T	uc002ojd.1	-	1	490	c.181G>A	c.(181-183)GAC>AAC	p.D61N		NM_144691	NP_653292	Q6ZSI9	CAN12_HUMAN	calpain 12	61	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CCCAGCTGGTCATAGCCAAGG	0.502													22	36					0	0	0	0	T	39234625	T	T	39234625	3	4	26	1	0	0	0	0	1	0	0	0	2637	826	29	2	2062	2	CAPN12	19	39234625	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	19878408	39234625	19894358	267	5414											
ZFP36	7538	broad.mit.edu	37	chr19	39898586	39898586	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgcccccaccccctggcttCgcaccgctggctccccgcct	2	7	9	23	3	0	0	0	0	0	0	2	0	1	0	8	2	1	4	8	2	0	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:39898586C>T	uc002olh.1	+	2	286	c.228C>T	c.(226-228)TTC>TTT	p.F76F	ZFP36_uc010egn.1_5'UTR	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	76					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCCCTGGCTTCGCACCGCTGG	0.706													22	33					0	0	0	0	T	39898586	T	T	39898586	2	4	26	1	0	0	0	0	0	0	0	1	17712	883	31	1		1	ZFP36	19	39898586	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	663961	39898586	19230397	268	5415											
PRX	57716	broad.mit.edu	37	chr19	40902497	40902497	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tttcatctcaggcacctttgGaagcttcatctcagggactt	8	14	8	11	0	4	0	4	0	2	0	6	2	4	2	1	3	1	2	1	3	1	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:40902497G>C	uc002onr.2	-	7	2031	c.1762C>G	c.(1762-1764)CCA>GCA	p.P588A	PRX_uc002onq.2_Missense_Mutation_p.P449A|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	588	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCACCTTTGGAAGCTTCATC	0.567													90	198					0	0	0	0	C	40902497	C	C	40902497	3	2	26	1	0	0	0	0	1	0	0	0	12704	1174	41	2	2627	2	PRX	19	40902497	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1003911	40902497	18226486	269	5416											
ZNF284	342909	broad.mit.edu	37	chr19	44591044	44591044	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtgggcctcaggtattttGagacataagagactccatac	12	10	11	8	0	1	2	1	1	0	2	2	4	2	2	2	3	1	1	2	3	3	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:44591044G>C	uc002oyg.1	+	5	1629	c.1413G>C	c.(1411-1413)TTG>TTC	p.L471F	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	471	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				CAGGTATTTTGAGACATAAGA	0.413													33	37					0	0	0	0	C	44591044	C	C	44591044	3	2	26	1	0	0	0	0	1	0	0	0	17888	1281	45	2	1427	2	ZNF284	19	44591044	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	3688547	44591044	14537939	270	5417											
MARK4	57787	broad.mit.edu	37	chr19	45783693	45783693	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagtccttgaccagccagaaGtacaacgaagtgaccgccac	13	5	10	13	2	0	3	0	2	0	1	1	5	1	3	5	0	3	1	5	0	4	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:45783693G>A	uc002pbb.1	+	11	1073	c.1068G>A	c.(1066-1068)AAG>AAA	p.K356K	MARK4_uc002paz.1_Missense_Mutation_p.V94I|MARK4_uc002pba.1_Silent_p.K356K|MARK4_uc002pbc.1_Silent_p.K222K			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	356	UBA.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCAGCCAGAAGTACAACGAAG	0.607													67	125					0	0	0	0	A	45783693	A	A	45783693	2	1	26	1	0	0	0	0	0	0	0	1	9368	1020	36	4		4	MARK4	19	45783693	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1192649	45783693	13345290	271	5418											
DHX34	9704	broad.mit.edu	37	chr19	47884111	47884111	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cggctcacagggctagaagtCcagaacatgtatgtgggacc	11	7	13	10	1	1	2	1	0	0	2	2	3	2	3	2	3	1	3	2	3	4	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:47884111C>G	uc010xyn.1	+	15	3362	c.3021C>G	c.(3019-3021)GTC>GTG	p.V1007V	DHX34_uc010xyo.1_Silent_p.V136V	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	1007						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GGCTAGAAGTCCAGAACATGT	0.438													30	44					0	0	0	0	G	47884111	G	G	47884111	2	3	26	1	0	0	0	0	0	0	0	1	4529	842	30	2		2	DHX34	19	47884111	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	2100418	47884111	11244872	272	5419											
GLTSCR2	29997	broad.mit.edu	37	chr19	48258620	48258620	+	Frame_Shift_Del	DEL	G	-	-																															cacagcgggtacagcaggccGcgttgcgggccgcccggctc																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:48258620delG	uc002phm.2	+	9	1093	c.1069delG	c.(1069-1071)GCGfs	p.A357fs	GLTSCR2_uc002phk.2_Frame_Shift_Del_p.A357fs|GLTSCR2_uc002phl.2_Frame_Shift_Del_p.A357fs|GLTSCR2_uc010elj.2_Frame_Shift_Del_p.A357fs|GLTSCR2_uc010elk.1_RNA|SNORD23_uc010ell.2_5'Flank	NM_015710	NP_056525	Q9NZM5	GSCR2_HUMAN	glioma tumor suppressor candidate region gene 2	357						nucleolus				central_nervous_system(1)	1		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)		ACAGCAGGCCGCGTTGCGGGC	0.657													---	---	---								-	48258620	-	-	48258620	7	5	26	1	0	1	0	1	0	0	0	0	6512	1087	38	0	1103	0	GLTSCR2	19	48258620	Frame_Shift_Del	DEL	G	TCGA-BB-4227-01A-01D-1870-08	374509	48258620	10870363	273	5420											
FAM83E	54854	broad.mit.edu	37	chr19	49106753	49106753	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagccacaaggtctcacctCgttgtccccatcactggagc	8	8	8	17	1	2	0	2	0	1	0	5	1	3	1	5	2	2	1	5	2	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:49106753C>T	uc002pjn.2	-	4	1239	c.1174G>A	c.(1174-1176)GAG>AAG	p.E392K		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	392										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GGTCTCACCTCGTTGTCCCCA	0.532													12	24					0	0	0	0	T	49106753	T	T	49106753	3	4	26	1	0	0	0	0	1	0	0	0	5669	893	31	1	270	1	FAM83E	19	49106753	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	848133	49106753	10022230	274	5421											
SCAF1	58506	broad.mit.edu	37	chr19	50156573	50156573	+	Frame_Shift_Del	DEL	C	-	-																															ggcagccaaggttcctagcaCcccgccccccaaggcagccc																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:50156573delC	uc002poq.2	+	7	3051	c.2927delC	c.(2926-2928)ACCfs	p.T976fs		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	976					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GTTCCTAGCACCCCGCCCCCC	0.682													---	---	---								-	50156573	-	-	50156573	7	5	26	1	0	1	0	1	0	0	0	0	13933	507	18	0	2949	0	SCAF1	19	50156573	Frame_Shift_Del	DEL	C	TCGA-BB-4227-01A-01D-1870-08	1049820	50156573	8972410	275	5422											
TSKS	60385	broad.mit.edu	37	chr19	50247585	50247585	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaattgccgcccgaactcctCcagaatgggtttcagtgggc	9	9	11	12	2	1	1	1	0	0	1	3	2	3	1	4	2	2	1	4	2	3	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:50247585C>G	uc002ppm.2	-	8	1275	c.1264G>C	c.(1264-1266)GAG>CAG	p.E422Q		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	422							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CCGAACTCCTCCAGAATGGGT	0.597													32	52					0	0	0	0	G	50247585	G	G	50247585	3	3	26	1	0	0	0	0	1	0	0	0	16693	864	30	2	530	2	TSKS	19	50247585	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	91012	50247585	8881398	276	5423											
KLK2	3817	broad.mit.edu	37	chr19	51379884	51379884	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagactccagccatgacctCatgctgctccgcctgtcaga	9	8	9	15	1	2	3	2	1	0	2	4	4	4	3	5	0	3	2	5	0	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:51379884C>G	uc002ptv.2	+	3	404	c.363C>G	c.(361-363)CTC>CTG	p.L121L	KLK2_uc010eog.2_Silent_p.L19L|KLK2_uc010yck.1_Silent_p.L121L|KLK2_uc002ptu.2_Silent_p.L121L|KLK2_uc002ptt.2_RNA|KLK2_uc010ycl.1_Silent_p.L104L|KLK2_uc010ycm.1_Silent_p.L19L|KLK2_uc010eoh.2_Silent_p.L19L	NM_005551	NP_005542	P20151	KLK2_HUMAN	kallikrein 2, prostatic isoform 1	121	Peptidase S1.				proteolysis		serine-type endopeptidase activity			ovary(1)|skin(1)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		GCCATGACCTCATGCTGCTCC	0.582			T	ETV4	prostate								24	42					0	0	0	0	G	51379884	G	G	51379884	2	3	26	1	0	0	0	0	0	0	0	1	8443	813	29	2		2	KLK2	19	51379884	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1132299	51379884	7749099	277	5424											
ZNF836	162962	broad.mit.edu	37	chr19	52659059	52659059	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgaattctcttatgatttGaaaggtttccactgtcattg	10	18	7	6	0	2	3	1	3	1	0	4	3	3	3	1	1	0	1	1	1	4	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:52659059G>C	uc010ydi.1	-	5	2251	c.1877C>G	c.(1876-1878)TCA>TGA	p.S626*	ZNF836_uc010ydj.1_Nonsense_Mutation_p.S626*	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	626	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTATGATTTGAAAGGTTTCC	0.408													77	141					0	0	0	0	C	52659059	C	C	52659059	4	2	26	1	0	0	0	0	0	1	0	0	18254	1294	45	2	935	2	ZNF836	19	52659059	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	1279175	52659059	6469924	278	5425											
ZNF347	84671	broad.mit.edu	37	chr19	53643671	53643671	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtctgatgggtagttaggcTtgaacagatactaaagggtt	11	13	13	4	0	1	3	0	2	1	1	1	3	1	3	0	3	2	4	0	3	6	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:53643671T>C	uc002qbb.1	-	5	2479	c.2410A>G	c.(2410-2412)AGC>GGC	p.S804G	ZNF347_uc010eql.1_Missense_Mutation_p.S805G|ZNF347_uc002qbc.1_Missense_Mutation_p.S805G	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	804	C2H2-type 20; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		GTAGTTAGGCTTGAACAGATA	0.418													66	101					0	0	0	0	C	53643671	C	C	53643671	3	2	26	1	0	0	0	0	1	0	0	0	17928	1609	56	5	113	5	ZNF347	19	53643671	Missense_Mutation	SNP	T	TCGA-BB-4227-01A-01D-1870-08	984612	53643671	5485312	279	5426											
ZNF211	10520	broad.mit.edu	37	chr19	58146057	58146057	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggaggaatgggatctccttGatgaggctcagaaacacctg	11	8	14	8	0	2	3	1	2	1	1	3	6	2	6	2	4	1	1	2	4	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:58146057G>C	uc002qpq.2	+	2	331	c.151G>C	c.(151-153)GAT>CAT	p.D51H	ZNF211_uc010yhb.1_Missense_Mutation_p.D55H|ZNF211_uc002qpp.2_Missense_Mutation_p.D64H|ZNF211_uc002qpr.2_Missense_Mutation_p.D63H|ZNF211_uc002qps.2_Missense_Mutation_p.D64H|ZNF211_uc002qpt.2_Missense_Mutation_p.D63H|ZNF211_uc010yhc.1_Missense_Mutation_p.D63H|ZNF211_uc010yhd.1_5'UTR|ZNF211_uc010yhe.1_5'UTR	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	51	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGATCTCCTTGATGAGGCTCA	0.498													4	127					0	0	0	0	C	58146057	C	C	58146057	3	2	26	1	0	0	0	0	1	0	0	0	17834	1290	45	2	200	2	ZNF211	19	58146057	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	4502386	58146057	982926	280	5427											
MZF1	7593	broad.mit.edu	37	chr19	59080894	59080894	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggacttacctgggcctcctCaggcaggagggtgggtacag	8	7	16	10	0	1	0	1	0	0	0	2	2	2	2	3	6	2	2	3	6	2	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr19:59080894C>G	uc002qto.2	-	4	1201	c.640G>C	c.(640-642)GAG>CAG	p.E214Q	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Missense_Mutation_p.E214Q|MZF1_uc010euu.1_Missense_Mutation_p.E255Q	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	214					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		TGGGCCTCCTCAGGCAGGAGG	0.597													30	45					0	0	0	0	G	59080894	G	G	59080894	3	3	26	1	0	0	0	0	1	0	0	0	10161	835	29	2	1576	2	MZF1	19	59080894	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	934837	59080894	48089	281	5428											
ITCH	83737	broad.mit.edu	37	chr20	33001680	33001680	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caatggtgaaactacatgttCagaaagtaagtgactacctt	15	11	8	7	0	1	3	1	2	0	1	1	3	1	3	1	1	3	2	1	1	6	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:33001680C>T	uc010geu.1	+	6	662	c.470C>T	c.(469-471)TCA>TTA	p.S157L	ITCH_uc002xak.2_Missense_Mutation_p.S157L|ITCH_uc010zuj.1_Missense_Mutation_p.S47L	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	157					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						ACTACATGTTCAGAAAGTAAG	0.328													22	28					0	0	0	0	T	33001680	T	T	33001680	3	4	26	1	0	0	0	0	1	0	0	0	7907	838	29	2	484	2	ITCH	20	33001680	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08		33001680	30023840	282	5429											
CEP250	11190	broad.mit.edu	37	chr20	34090860	34090860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaaaagcagttggttactCtggaatgcctggccctggaa	11	10	12	8	0	1	1	0	1	1	0	1	3	1	3	2	4	3	3	2	4	5	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:34090860C>G	uc002xcm.2	+	31	5334	c.4663C>G	c.(4663-4665)CTG>GTG	p.L1555V	CEP250_uc010zve.1_Missense_Mutation_p.L923V	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1555	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GTTGGTTACTCTGGAATGCCT	0.498													27	82					0	0	0	0	G	34090860	G	G	34090860	3	3	26	1	0	0	0	0	1	0	0	0	3267	912	32	2	4769	2	CEP250	20	34090860	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	1089180	34090860	28934660	283	5430											
CEP250	11190	broad.mit.edu	37	chr20	34091370	34091370	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcacagcgcgggagcctaGagcacatgaagctgatcctg	12	5	13	11	2	0	3	0	2	0	1	1	4	1	4	2	1	5	3	2	1	3	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:34091370G>C	uc002xcm.2	+	31	5844	c.5173G>C	c.(5173-5175)GAG>CAG	p.E1725Q	CEP250_uc010zve.1_Missense_Mutation_p.E1093Q	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1725	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CGGGAGCCTAGAGCACATGAA	0.577													56	92					0	0	0	0	C	34091370	C	C	34091370	3	2	26	1	0	0	0	0	1	0	0	0	3267	943	33	2	5279	2	CEP250	20	34091370	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	510	34091370	28934150	284	5431											
DLGAP4	22839	broad.mit.edu	37	chr20	35155318	35155330	+	Frame_Shift_Del	DEL	GAGGCCCGCAAGA	-	-																															ccagcgacaagcagcgccagGaggcccgcaagagactcctg																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:35155318_35155330delGAGGCCCGCAAGA	uc002xff.2	+	13	3289_3301	c.2854_2866delGAGGCCCGCAAGA	c.(2854-2868)GAGGCCCGCAAGAGAfs	p.E952fs	DLGAP4_uc010zvp.1_Frame_Shift_Del_p.E952fs|DLGAP4_uc002xfg.2_Frame_Shift_Del_p.E248fs|DLGAP4_uc002xfh.2_Frame_Shift_Del_p.E416fs|DLGAP4_uc002xfi.2_3'UTR|DLGAP4_uc002xfj.2_Frame_Shift_Del_p.E248fs|uc002xfk.3_Intron	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	955_959					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				GCAGCGCCAGGAGGCCCGCAAGAGACTCCTGGC	0.638													---	---	---								-	35155330	-	-	35155318	7	5	26	1	0	1	0	1	0	0	0	0	4584	1175	41	0	3024	0	DLGAP4	20	35155318	Frame_Shift_Del	DEL	GAGGCCCGCAAGA	TCGA-BB-4227-01A-01D-1870-08	1063948	35155318	27870202	285	5432											
MYL9	10398	broad.mit.edu	37	chr20	35173441	35173441	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtgatggcttcattgacaagGaggacctgcacgacatgctg	10	9	13	9	1	1	2	1	2	0	0	1	5	1	4	1	3	2	3	1	3	1	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:35173441G>T	uc002xfl.1	+	2	248	c.154G>T	c.(154-156)GAG>TAG	p.E52*	uc002xfk.3_Intron|MYL9_uc002xfm.1_Nonsense_Mutation_p.E52*	NM_006097	NP_006088	P24844	MYL9_HUMAN	myosin regulatory light chain 9 isoform a	52	|EF-hand 1.				axon guidance|muscle contraction|regulation of muscle contraction	cytosol|muscle myosin complex	calcium ion binding|structural constituent of muscle				0	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CATTGACAAGGAGGACCTGCA	0.542													13	74					3.41278e-10	3.53776e-10	1	0	T	35173441	T	T	35173441	4	4	26	1	0	0	0	0	0	1	0	0	10107	1175	41	2	156	2	MYL9	20	35173441	Nonsense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	18123	35173441	27852079	286	5433											
C20orf117	140710	broad.mit.edu	37	chr20	35444081	35444081	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggttctcgtactgcagcttCttgaccttgccgctgagctc	4	13	10	14	3	2	2	0	2	2	0	4	2	2	2	2	1	5	6	2	1	1	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:35444081C>T	uc002xgd.1	-	5	1377	c.1050G>A	c.(1048-1050)AAG>AAA	p.K350K	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	350											0		Myeloproliferative disorder(115;0.00874)				ACTGCAGCTTCTTGACCTTGC	0.647													6	9					0	0	0	0	T	35444081	T	T	35444081	2	4	26	1	0	0	0	0	0	0	0	1	2093	912	32	2		2	C20orf117	20	35444081	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	270640	35444081	27581439	287	5434											
ZHX3	23051	broad.mit.edu	37	chr20	39831571	39831571	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcattcacttttttccgtctCtctgaaaaccagctatcaat	10	15	4	12	1	4	1	2	1	2	0	6	1	5	1	2	0	2	2	2	0	4	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:39831571C>G	uc002xjs.1	-	3	2364	c.1986G>C	c.(1984-1986)GAG>GAC	p.E662D	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.E662D|ZHX3_uc002xjt.1_Missense_Mutation_p.E662D|ZHX3_uc002xju.1_Missense_Mutation_p.E662D|ZHX3_uc002xjv.1_Missense_Mutation_p.E662D|ZHX3_uc002xjw.1_Missense_Mutation_p.E662D|ZHX3_uc010ggg.1_Missense_Mutation_p.E662D	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	662	Homeobox 3.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				TTTTCCGTCTCTCTGAAAACC	0.493													103	182					0	0	0	0	G	39831571	G	G	39831571	3	3	26	1	0	0	0	0	1	0	0	0	17744	912	32	2	892	2	ZHX3	20	39831571	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	4387490	39831571	23193949	288	5435											
SFRS6	6431	broad.mit.edu	37	chr20	42086714	42086714	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgcctgagctacaacgtccGggagaaggacatccagcgct	11	5	12	13	4	0	2	0	1	0	1	2	4	2	3	3	2	4	2	3	2	3	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:42086714G>C	uc010zwg.1	+	1	211	c.41G>C	c.(40-42)CGG>CCG	p.R14P	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Missense_Mutation_p.R14P	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	14	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TACAACGTCCGGGAGAAGGAC	0.647													27	39					0	0	0	0	C	42086714	C	C	42086714	3	2	26	1	0	0	0	0	1	0	0	0	14246	1116	39	3	43	3	SFRS6	20	42086714	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2255143	42086714	20938806	289	5436											
TSHZ2	128553	broad.mit.edu	37	chr20	51871400	51871400	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaagagagtaaaaaagaaaGgccagaggaaaccagcaagg	22	1	13	5	0	0	3	0	0	0	3	0	6	0	4	2	3	2	2	2	3	7	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr20:51871400G>C	uc002xwo.2	+	2	2359	c.1403G>C	c.(1402-1404)AGG>ACG	p.R468T		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	468					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AAAAAAGAAAGGCCAGAGGAA	0.423													56	96					0	0	0	0	C	51871400	C	C	51871400	3	2	26	1	0	0	0	0	1	0	0	0	16691	1000	35	4	1409	4	TSHZ2	20	51871400	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	9784686	51871400	11154120	290	5437											
HUNK	30811	broad.mit.edu	37	chr21	33371383	33371383	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgttaaggaagcgccatcaGagtctgcagccatctgcaga	12	8	11	10	1	3	2	1	0	2	2	3	3	3	3	2	1	4	3	2	1	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr21:33371383G>C	uc002yph.2	+	11	2391	c.2031G>C	c.(2029-2031)CAG>CAC	p.Q677H		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	677					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						AGCGCCATCAGAGTCTGCAGC	0.612													30	63					0	0	0	0	C	33371383	C	C	33371383	3	2	26	1	0	0	0	0	1	0	0	0	7497	933	33	2	2073	2	HUNK	21	33371383	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08		33371383	14758512	291	5438											
SLC5A3	6526	broad.mit.edu	37	chr21	35467896	35467896	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagccttgtctctgattctCtatattttcaccaagctctc	7	16	5	13	0	4	1	1	1	3	0	7	1	4	1	2	0	2	2	2	0	3	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr21:35467896C>G	uc002yto.2	+	2	911	c.399C>G	c.(397-399)CTC>CTG	p.L133L	MRPS6_uc002ytp.2_Intron	NM_006933	NP_008864	P53794	SC5A3_HUMAN	solute carrier family 5 (inositol transporters),	133	Helical; (Potential).					integral to plasma membrane	myo-inositol:sodium symporter activity			ovary(2)	2						CTCTGATTCTCTATATTTTCA	0.448													92	170					0	0	0	0	G	35467896	G	G	35467896	2	3	26	1	0	0	0	0	0	0	0	1	14730	900	32	2		2	SLC5A3	21	35467896	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	2096513	35467896	12661999	292	5439											
UMODL1	89766	broad.mit.edu	37	chr21	43531075	43531075	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcacgggaacagcagccctCggcctagagaacttcacctt	10	6	11	14	2	1	1	1	0	0	1	2	3	1	2	3	3	4	2	3	3	3	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr21:43531075C>T	uc002zaf.1	+	11	1743	c.1743C>T	c.(1741-1743)CTC>CTT	p.L581L	UMODL1_uc002zad.1_Silent_p.L509L|UMODL1_uc002zae.1_Silent_p.L509L|UMODL1_uc002zag.1_Silent_p.L581L|C21orf128_uc002zak.2_5'Flank	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	581	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CAGCAGCCCTCGGCCTAGAGA	0.657													18	42					0	0	0	0	T	43531075	T	T	43531075	2	4	26	1	0	0	0	0	0	0	0	1	17048	871	31	1		1	UMODL1	21	43531075	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08	8063179	43531075	4598820	293	5440											
TSSK2	23617	broad.mit.edu	37	chr22	19119070	19119070	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaacacctactgactttgTggagagattccttcctcggg	10	11	10	10	1	0	2	0	1	0	1	3	5	2	3	3	2	2	0	3	2	3	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:19119070T>G	uc002zow.2	+	1	750	c.158T>G	c.(157-159)GTG>GGG	p.V53G	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	53	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					ACTGACTTTGTGGAGAGATTC	0.498													22	30					0	0	0	0	G	19119070	G	G	19119070	3	3	26	1	0	0	0	0	1	0	0	0	16736	1696	59	5	160	5	TSSK2	22	19119070	Missense_Mutation	SNP	T	TCGA-BB-4227-01A-01D-1870-08		19119070	32185496	294	5441											
TOP3B	8940	broad.mit.edu	37	chr22	22317203	22317203	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctctgcaggtacttgcagtCatggctgaccgtggcgatga	7	10	14	10	2	2	2	1	2	1	0	2	3	2	2	1	3	3	5	1	3	1	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:22317203C>G	uc002zvs.2	-	12	1702	c.1267G>C	c.(1267-1269)GAC>CAC	p.D423H	TOP3B_uc010gtm.1_5'UTR|TOP3B_uc002zvr.2_Missense_Mutation_p.D148H|TOP3B_uc010gtl.2_Missense_Mutation_p.D423H|TOP3B_uc002zvt.3_Missense_Mutation_p.D423H	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	423					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TACTTGCAGTCATGGCTGACC	0.612													36	64					0	0	0	0	G	22317203	G	G	22317203	3	3	26	1	0	0	0	0	1	0	0	0	16435	826	29	2	1349	2	TOP3B	22	22317203	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	3198133	22317203	28987363	295	5442											
CABIN1	23523	broad.mit.edu	37	chr22	24483645	24483645	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcagtggagaggcgagctGccccctgagctcgtgcagca	9	5	15	12	2	0	2	0	1	0	1	1	4	0	2	2	2	6	5	2	2	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:24483645G>A	uc002zzi.1	+	23	3631	c.3504G>A	c.(3502-3504)CTG>CTA	p.L1168L	CABIN1_uc002zzj.1_Silent_p.L1118L|CABIN1_uc002zzl.1_Silent_p.L1168L	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1168					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GAGGCGAGCTGCCCCCTGAGC	0.567													54	63					0	0	0	0	A	24483645	A	A	24483645	2	1	26	1	0	0	0	0	0	0	0	1	2540	1306	46	4		4	CABIN1	22	24483645	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	2166442	24483645	26820921	296	5443											
RFPL2	10739	broad.mit.edu	37	chr22	32590359	32590359	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gctggaagctcctctgtcctCcagctgcttccactgggcgc	4	10	11	16	1	1	0	0	0	1	0	5	1	5	1	4	2	3	4	4	2	1	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:32590359C>G	uc003amg.3	-	3	1174	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	RFPL2_uc003ame.3_5'Flank|RFPL2_uc003amf.3_5'UTR|RFPL2_uc003amh.3_Intron	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	80							zinc ion binding			skin(1)	1						CCTCTGTCCTCCAGCTGCTTC	0.562													15	23					0	0	0	0	G	32590359	G	G	32590359	3	3	26	1	0	0	0	0	1	0	0	0	13319	864	30	2	992	2	RFPL2	22	32590359	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	8106714	32590359	18714207	297	5444											
RAC2	5880	broad.mit.edu	37	chr22	37637674	37637674	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgttggtggtgtagctgatGagaaggcaggtcttgcccac	7	10	16	8	1	1	2	0	2	1	1	1	3	1	2	1	4	2	4	1	4	2	3			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:37637674G>A	uc003arc.2	-	2	177	c.60C>T	c.(58-60)CTC>CTT	p.L20L		NM_002872	NP_002863	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2	20					axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			breast(2)|central_nervous_system(1)|skin(1)	4						TGTAGCTGATGAGAAGGCAGG	0.622													52	72					0	0	0	0	A	37637674	A	A	37637674	2	1	26	1	0	0	0	0	0	0	0	1	13040	1277	45	2		2	RAC2	22	37637674	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	5047315	37637674	13666892	298	5445											
TOB2	10766	broad.mit.edu	37	chr22	41832490	41832490	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aggtgccagccccactgcctCcaaacgggcctggggtgccg	6	5	14	16	2	0	0	0	0	0	0	1	0	1	0	7	4	5	0	7	4	1	0			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:41832490C>G	uc003azz.1	-	2	1567	c.860G>C	c.(859-861)GGA>GCA	p.G287A		NM_016272	NP_057356	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	287				QGSGTPGPFGGSGAGTCNSSSFDMAQVFGGGANSLFLEKT -> RAAAPQARLEAVGLAPATAAALTWPRYLEVVPTASSWR RH (in Ref. 1; BAA10971).	female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				ovary(1)	1						CCCACTGCCTCCAAACGGGCC	0.378													25	24					0	0	0	0	G	41832490	G	G	41832490	3	3	26	1	0	0	0	0	1	0	0	0	16414	855	30	2	178	2	TOB2	22	41832490	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	4194816	41832490	9472076	299	5446											
SAPS2	9701	broad.mit.edu	37	chr22	50854547	50854547	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgaagagaaggtcatccaGaggcttgtggagttgatcca	13	9	13	6	0	1	4	1	2	0	2	3	6	3	5	2	3	0	2	2	3	3	2			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chr22:50854547G>A	uc003blb.1	+	7	1001	c.579G>A	c.(577-579)CAG>CAA	p.Q193Q	SAPS2_uc003bky.1_Silent_p.Q193Q|SAPS2_uc003bkz.1_Silent_p.Q193Q|SAPS2_uc003blc.2_Silent_p.Q193Q|SAPS2_uc003bla.1_Silent_p.Q193Q	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	193						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		AGGTCATCCAGAGGCTTGTGG	0.517													10	78					0	0	0	0	A	50854547	A	A	50854547	2	1	26	1	0	0	0	0	0	0	0	1	13902	933	33	2		2	SAPS2	22	50854547	Silent	SNP	G	TCGA-BB-4227-01A-01D-1870-08	9022057	50854547	450019	300	5447											
PPP2R3B	28227	broad.mit.edu	37	chrX	299609	299609	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagccagcttgcagcgcttCaggtcctgcagcgtgatctt	6	12	11	12	2	2	1	1	1	1	0	3	1	3	1	2	1	6	4	2	1	1	4			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:299609C>G	uc004cpg.2	-	11	1575	c.1374G>C	c.(1372-1374)CTG>CTC	p.L458L	PPP2R3B_uc004cpf.2_Silent_p.L59L	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	458					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGCAGCGCTTCAGGTCCTGCA	0.622													26	111					0	0	0	0	G	299609	G	G	299609	2	3	26	1	0	0	0	0	0	0	0	1	12449	813	29	2		2	PPP2R3B	23	299609	Silent	SNP	C	TCGA-BB-4227-01A-01D-1870-08		299609	154970951	301	5448											
ATXN3L	92552	broad.mit.edu	37	chrX	13337468	13337469	+	Frame_Shift_Ins	INS	-	T	T																															tgctctttttgttttactaaINStttttttccattaagttttg																										TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:13337468_13337469insT	uc010ned.2	-	1	1050_1051	c.585_586insA	c.(583-588)AAATTAfs	p.K195fs		NM_001135995	NP_001129467	Q9H3M9	ATX3L_HUMAN	ataxin 3-like	195_196					protein deubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ubiquitin-specific protease activity			lung(2)|ovary(2)|large_intestine(1)|skin(1)	6						TGTTTTACTAATTTTTTTCCAT	0.381													---	---	---								T	13337469	T	T	13337468	7	5	26	1	0	1	1	0	0	0	0	0	1216	98	4	0	485	0	ATXN3L	23	13337468	Frame_Shift_Ins	INS	-	TCGA-BB-4227-01A-01D-1870-08	13037859	13337468	141933092	302	5449											
USP11	8237	broad.mit.edu	37	chrX	47098752	47098752	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccacccccgccccacagatGagataaactggcgcctcaag	11	5	8	17	2	1	2	1	1	0	2	2	3	2	2	6	1	1	0	6	1	3	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:47098752G>C	uc004dhp.2	+	3	418	c.418G>C	c.(418-420)GAG>CAG	p.E140Q	USP11_uc004dhq.2_5'UTR	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	140	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CCCCACAGATGAGATAAACTG	0.562													17	5					0	0	0	0	C	47098752	C	C	47098752	3	2	26	1	0	0	0	0	1	0	0	0	17110	1291	45	2	428	2	USP11	23	47098752	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	33761284	47098752	108171808	303	5450											
ARHGEF9	23229	broad.mit.edu	37	chrX	62917013	62917013	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taagatacttacgtgctctaGgaagcagggtcctatctcgc	10	11	10	10	2	2	1	0	0	2	1	4	2	3	2	1	2	4	2	1	2	6	5			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:62917013G>C	uc004dvl.2	-	4	1392	c.553C>G	c.(553-555)CTA>GTA	p.L185V	ARHGEF9_uc004dvj.1_Missense_Mutation_p.L74V|ARHGEF9_uc004dvk.1_Missense_Mutation_p.L47V|ARHGEF9_uc011mos.1_Missense_Mutation_p.L164V|ARHGEF9_uc004dvm.1_Missense_Mutation_p.L164V|ARHGEF9_uc011mot.1_Missense_Mutation_p.L132V|ARHGEF9_uc004dvn.2_Missense_Mutation_p.L192V	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	185	DH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						ACGTGCTCTAGGAAGCAGGGT	0.458													16	2					0	0	0	0	C	62917013	C	C	62917013	3	2	26	1	0	0	0	0	1	0	0	0	912	991	35	4	1025	4	ARHGEF9	23	62917013	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	15818261	62917013	92353547	304	5451											
ITGB1BP2	26548	broad.mit.edu	37	chrX	70524109	70524109	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgactgtatatggccagattCcacttcctgcgtttaactgg	8	14	9	10	1	0	2	0	1	0	1	2	2	2	2	3	2	2	2	3	2	3	6			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:70524109C>T	uc004dzr.1	+	9	741	c.712C>T	c.(712-714)CCA>TCA	p.P238S	BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_Missense_Mutation_p.P220S	NM_012278	NP_036410	Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein 2	238	CS.				muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)					TGGCCAGATTCCACTTCCTGC	0.473													46	13					0	0	0	0	T	70524109	T	T	70524109	3	4	26	1	0	0	0	0	1	0	0	0	7931	855	30	2	746	2	ITGB1BP2	23	70524109	Missense_Mutation	SNP	C	TCGA-BB-4227-01A-01D-1870-08	7607096	70524109	84746451	305	5452											
ACRC	93953	broad.mit.edu	37	chrX	70814205	70814205	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atccttaatgtccagtcaagGagtggtgacaccagtgggtc	10	10	12	9	0	1	1	1	1	0	0	4	2	3	2	3	3	0	0	3	3	2	1			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:70814205G>C	uc004eae.2	+	5	666	c.165G>C	c.(163-165)AGG>AGC	p.R55S	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	55						nucleus				ovary(3)	3	Renal(35;0.156)					TCCAGTCAAGGAGTGGTGACA	0.403													32	8					0	0	0	0	C	70814205	C	C	70814205	3	2	26	1	0	0	0	0	1	0	0	0	171	1165	41	2	179	2	ACRC	23	70814205	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	290096	70814205	84456355	306	5453											
OCRL	4952	broad.mit.edu	37	chrX	128692624	128692624	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcagggcttcttggatttGaagacaatttttcttctatg	8	19	8	6	0	4	2	1	1	3	1	4	3	4	3	0	2	0	1	0	2	3	8			TCGA-BB-4227-01A-01D-1870-08	TCGA-BB-4227-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c1b315bb-773b-4fd0-88ec-d11044996adc	cca35864-76be-4095-afb4-eb4ca15b142c	g.chrX:128692624G>C	uc004euq.2	+	7	619	c.454G>C	c.(454-456)GAA>CAA	p.E152Q	OCRL_uc004eur.2_Missense_Mutation_p.E152Q	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	152					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						TCTTGGATTTGAAGACAATTT	0.408													3	52					0	0	0	0	C	128692624	C	C	128692624	3	2	26	1	0	0	0	0	1	0	0	0	10877	1291	45	2	480	2	OCRL	23	128692624	Missense_Mutation	SNP	G	TCGA-BB-4227-01A-01D-1870-08	57878419	128692624	26577936	307	5454											
CRCT1	54544	broad.mit.edu	37	chr1	152487926	152487926	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtcgtcccagggccccgctCcgtgtcccgccccggcgccc	1	5	13	22	6	0	0	0	0	0	0	4	0	3	0	8	3	0	1	8	3	0	0			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:152487926C>T	uc001ezz.2	+	2	140	c.67C>T	c.(67-69)CCG>TCG	p.P23S		NM_019060	NP_061933	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	23											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGccccgctccgtgtcccgc	0.473													19	13					0	0	0	0	T	152487926	T	T	152487926	3	4	27	1	0	0	0	0	1	0	0	0	3868	855	30	2	69	2	CRCT1	1	152487926	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08		152487926	96762695	1	5455											
KPRP	448834	broad.mit.edu	37	chr1	152732518	152732520	+	In_Frame_Del	DEL	AAC	-	-																															atgtagaatgcccagtccagAactatgtaccctgtccagct																										TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:152732518_152732520delAAC	uc001fal.1	+	2	512_514	c.454_456delAAC	c.(454-456)AACdel	p.N152del		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	152	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCAGTCCAGAACTATGTACCCT	0.507													---	---	---								-	152732520	-	-	152732518	7	5	27	1	0	1	0	1	0	0	0	0	8475	246	9	0	456	0	KPRP	1	152732518	In_Frame_Del	DEL	AAC	TCGA-BB-4228-01A-01D-1434-08	244592	152732518	96518103	2	5456											
KCNT2	343450	broad.mit.edu	37	chr1	196227545	196227545	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatcactggatgttgagttgCggtggttgctgcggtggtgc	4	13	18	6	2	1	1	1	1	0	0	1	3	1	2	0	5	4	4	0	5	0	3			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:196227545C>T	uc001gtd.1	-	26	3050	c.2990G>A	c.(2989-2991)CGC>CAC	p.R997H	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.R930H|KCNT2_uc001gtf.1_Missense_Mutation_p.R973H|KCNT2_uc001gtg.1_RNA|KCNT2_uc001gth.1_Missense_Mutation_p.R501H	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	997	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TGTTGAGTTGCGGTGGTTGCT	0.483													74	100					0	0	0	0	T	196227545	T	T	196227545	3	4	27	1	0	0	0	0	1	0	0	0	8131	768	27	1	429	1	KCNT2	1	196227545	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08	43495027	196227545	53023076	3	5457											
IRF2BP2	359948	broad.mit.edu	37	chr1	234743346	234743348	+	In_Frame_Del	DEL	TTG	-	-																															aggcatgactgccccctgcaTtgtctgctactaagatcagg																										TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr1:234743346_234743348delTTG	uc001hwg.2	-	2	1330_1332	c.1299_1301delCAA	c.(1297-1302)GACAAT>GAT	p.N434del	IRF2BP2_uc009xfw.2_In_Frame_Del_p.N44del|IRF2BP2_uc001hwf.2_In_Frame_Del_p.N418del	NM_182972	NP_892017	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			GCCCCCTGCATTGTCTGCTACTA	0.581													---	---	---								-	234743348	-	-	234743346	7	5	27	1	0	1	0	1	0	0	0	0	7869	1493	52	0	466	0	IRF2BP2	1	234743346	In_Frame_Del	DEL	TTG	TCGA-BB-4228-01A-01D-1434-08	38515801	234743346	14507275	4	5458											
COL3A1	1281	broad.mit.edu	37	chr2	189854843	189854843	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaatcaggtagacccggaCgacctggagagcgaggattg	12	5	16	8	3	1	3	1	0	0	3	1	9	1	5	2	4	1	1	2	4	2	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr2:189854843C>T	uc002uqj.1	+	9	829	c.712C>T	c.(712-714)CGA>TGA	p.R238*	COL3A1_uc010frw.1_5'Flank	NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	238	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TAGACCCGGACGACCTGGAGA	0.383													35	73					0	0	0	0	T	189854843	T	T	189854843	4	4	27	1	0	0	0	0	0	1	0	0	3703	528	19	1	746	1	COL3A1	2	189854843	Nonsense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08		189854843	53344530	5	5459											
IFRD2	7866	broad.mit.edu	37	chr3	50326114	50326114	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagcacctcaaagccgaagCgcactatctcttcttcgcat	11	9	7	14	3	3	1	1	0	2	1	5	2	3	1	2	0	3	3	2	0	3	3			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr3:50326114C>T	uc011bdp.1	-	10	1373	c.1244G>A	c.(1243-1245)CGC>CAC	p.R415H	IFRD2_uc003czb.2_Missense_Mutation_p.R517H	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	415							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AAAGCCGAAGCGCACTATCTC	0.597													18	2					0	0	0	0	T	50326114	T	T	50326114	3	4	27	1	0	0	0	0	1	0	0	0	7593	768	27	1	288	1	IFRD2	3	50326114	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08		50326114	147696316	6	5460											
MRPL3	11222	broad.mit.edu	37	chr3	131190031	131190031	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcacaccagttgcaacagctCcaggtctcctgtgggttttc	7	12	9	13	0	2	0	1	0	1	0	5	0	3	0	3	2	3	4	3	2	1	3			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr3:131190031C>A	uc003eoh.2	-	7	886	c.722G>T	c.(721-723)GGA>GTA	p.G241V	MRPL3_uc011blo.1_Missense_Mutation_p.G136V|MRPL3_uc011blp.1_Missense_Mutation_p.G268V	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	241					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						TGCAACAGCTCCAGGTCTCCT	0.423													8	148					0.00307968	0.00312367	1	0	A	131190031	A	A	131190031	3	1	27	1	0	0	0	0	1	0	0	0	9846	855	30	2	340	2	MRPL3	3	131190031	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08	80863917	131190031	66832399	7	5461											
TBC1D14	57533	broad.mit.edu	37	chr4	7016236	7016236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaatttgccgaaattatttgCgcatttcaagaagaacaacc	16	11	6	8	2	1	2	1	0	0	2	1	3	1	2	2	0	4	1	2	0	7	4			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr4:7016236C>T	uc011bwg.1	+	12	1788	c.1709C>T	c.(1708-1710)GCG>GTG	p.A570V	TBC1D14_uc003gjs.3_Missense_Mutation_p.A570V|TBC1D14_uc010idh.2_Missense_Mutation_p.A290V|TBC1D14_uc011bwh.1_Missense_Mutation_p.A217V|TBC1D14_uc003gju.3_Missense_Mutation_p.A61V	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	570	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						AAATTATTTGCGCATTTCAAG	0.358													3	66					0	0	0	0	T	7016236	T	T	7016236	3	4	27	1	0	0	0	0	1	0	0	0	15669	768	27	1	1758	1	TBC1D14	4	7016236	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08		7016236	184138040	8	5462											
FAT4	79633	broad.mit.edu	37	chr4	126372965	126372965	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaaatgtcttccacaggAactgtgcatatcacagttat	12	12	6	11	0	3	0	2	0	1	0	4	1	4	1	2	1	2	2	2	1	4	3			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr4:126372965A>G	uc003ifj.3	+	9	10794	c.10794A>G	c.(10792-10794)GGA>GGG	p.G3598G	FAT4_uc011cgp.1_Silent_p.G1896G|FAT4_uc003ifi.1_Silent_p.G1076G	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3598	Cadherin 34.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTTCCACAGGAACTGTGCATA	0.428													125	155					0	0	0	0	G	126372965	G	G	126372965	2	3	27	1	0	0	0	0	0	0	0	1	5724	233	9	5		5	FAT4	4	126372965	Silent	SNP	A	TCGA-BB-4228-01A-01D-1434-08	119356729	126372965	64781311	9	5463											
FBXW7	55294	broad.mit.edu	37	chr4	153247289	153247289	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccatcatattgaacacagcGgactgctgcaacatgaccca	13	7	8	13	1	1	2	1	2	0	0	1	3	1	3	2	1	5	2	2	1	3	2	rs149680468		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr4:153247289G>C	uc003ims.2	-	10	1662	c.1513C>G	c.(1513-1515)CGC>GGC	p.R505G	FBXW7_uc011cii.1_Missense_Mutation_p.R505G|FBXW7_uc003imt.2_Missense_Mutation_p.R505G|FBXW7_uc011cih.1_Missense_Mutation_p.R329G|FBXW7_uc003imq.2_Missense_Mutation_p.R425G|FBXW7_uc003imr.2_Missense_Mutation_p.R387G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468			Mis|N|D|F		colorectal|endometrial|T-ALL								100	120					0	0	0	0	C	153247289	C	C	153247289	3	2	27	1	0	0	0	0	1	0	0	0	5801	1116	39	3	622	3	FBXW7	4	153247289	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08	26874324	153247289	37906987	10	5464											
HMGCR	3156	broad.mit.edu	37	chr5	74651207	74651207	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagcttggtggaggtgccagCagccgagtccttgcagatgg	7	9	16	9	1	0	1	0	0	0	1	1	3	1	2	3	4	5	3	3	4	1	3			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr5:74651207C>A	uc003kdp.2	+	14	1896	c.1740C>A	c.(1738-1740)AGC>AGA	p.S580R	HMGCR_uc011cst.1_Missense_Mutation_p.S600R|HMGCR_uc003kdq.2_Missense_Mutation_p.S527R	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	580	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GAGGTGCCAGCAGCCGAGTCC	0.493													94	160					8.45e-40	9.23e-40	1	0	A	74651207	A	A	74651207	3	1	27	1	0	0	0	0	1	0	0	0	7270	709	25	4	1790	4	HMGCR	5	74651207	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08		74651207	106264053	11	5465											
PCDHA3	56145	broad.mit.edu	37	chr5	140181621	140181621	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaataaggatatcgcgtattCtttcaatacggacatgtcag	14	12	8	7	3	3	0	2	0	1	0	4	2	3	2	0	2	1	1	0	2	6	6			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr5:140181621C>G	uc003lhf.2	+	1	839	c.839C>G	c.(838-840)TCT>TGT	p.S280C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.S280C	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	280	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCGCGTATTCTTTCAATACG	0.388													69	78					0	0	0	0	G	140181621	G	G	140181621	3	3	27	1	0	0	0	0	1	0	0	0	11579	913	32	2	841	2	PCDHA3	5	140181621	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08	65530414	140181621	40733639	12	5466											
PIM1	5292	broad.mit.edu	37	chr6	37140830	37140830	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcgctaccatggcaggtcGgcggcagtctggtccctggg	5	8	15	13	3	1	0	0	0	1	0	4	0	2	0	2	6	1	3	2	6	1	1			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:37140830G>A	uc003onk.2	+	5	1096	c.666G>A	c.(664-666)TCG>TCA	p.S222S	PIM1_uc011dtw.1_Missense_Mutation_p.R91Q	NM_002648	NP_002639	P11309	PIM1_HUMAN	non-specific serine/threonine protein kinase	313	Protein kinase.				cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	ATGGCAGGTCGGCGGCAGTCT	0.522			T	BCL6	NHL								65	97					0	0	0	0	A	37140830	A	A	37140830	2	1	27	1	0	0	0	0	0	0	0	1	11982	1103	39	1		1	PIM1	6	37140830	Silent	SNP	G	TCGA-BB-4228-01A-01D-1434-08		37140830	133974237	13	5467											
SYNCRIP	10492	broad.mit.edu	37	chr6	86324547	86324547	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaaccatagttaccagaaTgatcaccaccttggagcggt	12	10	9	10	1	1	2	1	1	0	1	1	3	1	3	4	2	3	2	4	2	4	4	rs147197492		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:86324547T>A	uc003pla.2	-	11	2340	c.1799A>T	c.(1798-1800)CAT>CTT	p.H600L	SYNCRIP_uc003pku.2_Intron|SYNCRIP_uc003pkw.2_Intron|SYNCRIP_uc003pky.2_Intron|SYNCRIP_uc003pkv.2_Intron|SYNCRIP_uc003pkx.2_Intron|SYNCRIP_uc003pkz.2_Missense_Mutation_p.H565L	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	600					CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		GTTACCAGAATGATCACCACC	0.478													90	113					0	0	0	0	A	86324547	A	A	86324547	3	1	27	1	0	0	0	0	1	0	0	0	15510	1464	51	5	122	5	SYNCRIP	6	86324547	Missense_Mutation	SNP	T	TCGA-BB-4228-01A-01D-1434-08	49183717	86324547	84790520	14	5468											
C6orf174	387104	broad.mit.edu	37	chr6	127796906	127796906	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctccttcttgcccgcgtcGctctcggcgtcgctgtcgcg	0	12	11	18	8	3	0	0	0	3	0	8	0	3	0	2	1	1	2	2	1	0	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:127796906G>A	uc003qbd.2	-	6	3130	c.2265C>T	c.(2263-2265)AGC>AGT	p.S755S	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	755						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TGCCCGCGTCGCTCTCGGCGT	0.692													94	99					0	0	0	0	A	127796906	A	A	127796906	2	1	27	1	0	0	0	0	0	0	0	1	2355	1078	38	1		1	C6orf174	6	127796906	Silent	SNP	G	TCGA-BB-4228-01A-01D-1434-08	41472359	127796906	43318161	15	5469											
FNDC1	84624	broad.mit.edu	37	chr6	159653589	159653589	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccgtccagcgttctccGcgacagaagctctgtgcacc	6	8	10	17	4	2	1	0	0	2	1	5	2	4	1	5	0	3	3	5	0	1	1			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:159653589G>A	uc010kjv.2	+	11	2245	c.2045G>A	c.(2044-2046)CGC>CAC	p.R682H	FNDC1_uc010kjw.1_Missense_Mutation_p.R567H	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	682	Ser-rich.					extracellular region		p.R682H(1)		large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGCGTTCTCCGCGACAGAAGC	0.716													19	21					0	0	0	0	A	159653589	A	A	159653589	3	1	27	1	0	0	0	0	1	0	0	0	6000	1087	38	1	2087	1	FNDC1	6	159653589	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08	31856683	159653589	11461478	16	5470											
PLG	5340	broad.mit.edu	37	chr6	161155067	161155067	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgatgtaggtggtccctggtGctacacgacaaatccaagaa	12	9	11	9	1	0	2	0	1	0	1	2	3	2	2	2	3	2	2	2	3	5	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr6:161155067G>A	uc003qtm.3	+	13	1691	c.1628G>A	c.(1627-1629)TGC>TAC	p.C543Y		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	543	Kringle 5.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGTCCCTGGTGCTACACGACA	0.473													30	31					0	0	0	0	A	161155067	A	A	161155067	3	1	27	1	0	0	0	0	1	0	0	0	12141	1319	46	4	1682	4	PLG	6	161155067	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08	1501478	161155067	9960000	17	5471											
GNB2	2783	broad.mit.edu	37	chr7	100275401	100275401	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtcgtgttgccgcttcctgGatgacaaccaaatcatcacc	9	11	8	13	2	2	1	2	1	0	0	4	2	3	2	4	1	2	2	4	1	2	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr7:100275401G>A	uc003uwb.2	+	7	730	c.457G>A	c.(457-459)GAT>AAT	p.D153N	GNB2_uc003uwc.2_Missense_Mutation_p.D109N|GNB2_uc010lhd.2_Missense_Mutation_p.D109N|GNB2_uc010lhe.2_Missense_Mutation_p.D109N|GNB2_uc003uwd.2_Missense_Mutation_p.D53N|GNB2_uc010lhf.2_Missense_Mutation_p.D53N|GNB2_uc003uwe.2_Missense_Mutation_p.D153N|GNB2_uc003uwf.2_Missense_Mutation_p.D53N	NM_005273	NP_005264	P62879	GBB2_HUMAN	guanine nucleotide-binding protein, beta-2	153	WD 3.				cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	perinuclear region of cytoplasm|plasma membrane	GTPase activity|GTPase binding|signal transducer activity			ovary(2)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)	Ovarian(593;0.238)				CCGCTTCCTGGATGACAACCA	0.627													46	42					0	0	0	0	A	100275401	A	A	100275401	3	1	27	1	0	0	0	0	1	0	0	0	6554	1174	41	2	479	2	GNB2	7	100275401	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08		100275401	58863262	18	5472											
CSMD1	64478	broad.mit.edu	37	chr8	3245095	3245095	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtcacttagtgtgtacccCgggtcacagctgaaagtcac	9	10	10	12	2	3	1	3	1	0	0	4	1	3	1	2	1	2	2	2	1	3	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:3245095C>T	uc011kwk.1	-	18	3096	c.2706G>A	c.(2704-2706)CCG>CCA	p.P902P	CSMD1_uc011kwj.1_Silent_p.P294P|CSMD1_uc003wqe.2_Silent_p.P58P	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	902	Extracellular (Potential).|Sushi 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGTGTACCCCGGGTCACAGC	0.607													14	18					0	0	0	0	T	3245095	T	T	3245095	2	4	27	1	0	0	0	0	0	0	0	1	3961	639	23	1		1	CSMD1	8	3245095	Silent	SNP	C	TCGA-BB-4228-01A-01D-1434-08		3245095	143118927	19	5473											
FZD3	7976	broad.mit.edu	37	chr8	28384970	28384970	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgattgatgtcacaagattCcgttatcctgaaaggcctat	11	14	8	8	1	1	4	1	3	0	1	3	4	3	4	3	1	0	1	3	1	4	5			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:28384970C>A	uc003xgx.2	+	5	1171	c.693C>A	c.(691-693)TTC>TTA	p.F231L	FZD3_uc010lvb.2_Missense_Mutation_p.F231L	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	231	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		TCACAAGATTCCGTTATCCTG	0.353													86	280					5.72486e-32	6.06665e-32	1	0	A	28384970	A	A	28384970	3	1	27	1	0	0	0	0	1	0	0	0	6165	854	30	2	703	2	FZD3	8	28384970	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08	25139875	28384970	117979052	20	5474											
ADAM2	2515	broad.mit.edu	37	chr8	39624556	39624556	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctacacattctttcttttgAcataaactgatgggatgagg	11	14	8	8	0	2	3	0	3	2	0	2	4	2	4	1	2	2	0	1	2	3	6			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:39624556A>T	uc003xnj.2	-	14	1393	c.1318T>A	c.(1318-1320)TCA>ACA	p.S440T	ADAM2_uc003xnk.2_Missense_Mutation_p.S421T|ADAM2_uc011lck.1_Missense_Mutation_p.S440T|ADAM2_uc003xnl.2_Missense_Mutation_p.S314T	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	440	Extracellular (Potential).|Disintegrin.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTTTCTTTTGACATAAACTGA	0.343													331	117					0	0	0	0	T	39624556	T	T	39624556	3	4	27	1	0	0	0	0	1	0	0	0	241	275	10	5	917	5	ADAM2	8	39624556	Missense_Mutation	SNP	A	TCGA-BB-4228-01A-01D-1434-08	11239586	39624556	106739466	21	5475											
PEX2	5828	broad.mit.edu	37	chr8	77896111	77896111	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagcataccagattttttGatttttactgggtggctgat	10	16	9	6	0	0	3	0	2	0	1	0	3	0	3	1	2	4	2	1	2	3	7			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr8:77896111G>T	uc003yax.2	-	4	762	c.304C>A	c.(304-306)CAA>AAA	p.Q102K	PEX2_uc003yay.2_Missense_Mutation_p.Q102K|PEX2_uc003yaz.2_Missense_Mutation_p.Q102K	NM_000318	NP_000309	P28328	PEX2_HUMAN	peroxin 2	102					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			ovary(1)	1						CAGATTTTTTGATTTTTACTG	0.373													115	57					4.35912e-55	4.8359e-55	1	0	T	77896111	T	T	77896111	3	4	27	1	0	0	0	0	1	0	0	0	11800	1299	45	2	617	2	PEX2	8	77896111	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08	38271555	77896111	68467911	22	5476											
ARMC3	219681	broad.mit.edu	37	chr10	23270411	23270411	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaggcagcaaagattttttCaataatcagggtaagtcaac	15	11	8	7	0	4	1	4	0	0	1	4	1	4	1	0	2	2	3	0	2	5	5	rs146538646		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr10:23270411C>G	uc001irm.3	+	9	1142	c.1059C>G	c.(1057-1059)TTC>TTG	p.F353L	ARMC3_uc010qcv.1_Missense_Mutation_p.F353L|ARMC3_uc010qcw.1_Missense_Mutation_p.F90L	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	353	ARM 9.						binding				0						AAGATTTTTTCAATAATCAGG	0.363													57	62					0	0	0	0	G	23270411	G	G	23270411	3	3	27	1	0	0	0	0	1	0	0	0	954	825	29	2	1089	2	ARMC3	10	23270411	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08		23270411	112264336	23	5477											
AP2A2	161	broad.mit.edu	37	chr11	994108	994108	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agatgcccccattcccggagCgggagtcctccatcttggca	7	8	11	15	2	1	1	0	0	1	1	4	3	4	3	5	3	2	1	5	3	0	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:994108C>T	uc001lss.2	+	14	2000	c.1819C>T	c.(1819-1821)CGG>TGG	p.R607W	AP2A2_uc001lst.1_Missense_Mutation_p.R608W|AP2A2_uc009yco.1_RNA	NM_012305	NP_036437	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2	607					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		ATTCCCGGAGCGGGAGTCCTC	0.622													68	111					0	0	0	0	T	994108	T	T	994108	3	4	27	1	0	0	0	0	1	0	0	0	740	759	27	1	1873	1	AP2A2	11	994108	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08		994108	134012408	24	5478											
MUC5B	727897	broad.mit.edu	37	chr11	1263410	1263410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcacgcccaggacagagaCgacaatgagccccttgacta	13	4	10	14	2	0	3	0	2	0	1	0	6	0	4	3	1	2	1	3	1	2	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:1263410C>T	uc009ycr.1	+	47	7505	c.7379C>T	c.(7378-7380)ACG>ATG	p.T2460M	MUC5B_uc001ltb.2_Missense_Mutation_p.T1770M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1767	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGGACAGAGACGACAATGAGC	0.617													31	41					0	0	0	0	T	1263410	T	T	1263410	3	4	27	1	0	0	0	0	1	0	0	0	10032	536	19	1	5431	1	MUC5B	11	1263410	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08	269302	1263410	133743106	25	5479											
TMEM86A	144110	broad.mit.edu	37	chr11	18723189	18723189	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgcagccactggctcttcGgacaggtctggtgatggcag	7	9	14	11	1	2	1	0	1	2	0	3	2	2	2	1	5	2	3	1	5	0	1			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:18723189G>T	uc001moz.1	+	3	439	c.356G>T	c.(355-357)CGG>CTG	p.R119L		NM_153347	NP_699178	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	119						integral to membrane				ovary(1)	1						CTGGCTCTTCGGACAGGTCTG	0.612													58	73					2.56585e-57	2.89167e-57	1	0	T	18723189	T	T	18723189	3	4	27	1	0	0	0	0	1	0	0	0	16274	1116	39	3	366	3	TMEM86A	11	18723189	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08	17459779	18723189	116283327	26	5480											
DAGLA	747	broad.mit.edu	37	chr11	61488167	61488167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggtttgtgatcctgtccGtggtgctcttcggcctggtc	3	14	13	11	2	1	1	0	1	1	0	5	1	3	1	3	4	1	2	3	4	0	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:61488167G>A	uc001nsa.2	+	3	223	c.112G>A	c.(112-114)GTG>ATG	p.V38M		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	38	Helical; (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GATCCTGTCCGTGGTGCTCTT	0.637													48	60					0	0	0	0	A	61488167	A	A	61488167	3	1	27	1	0	0	0	0	1	0	0	0	4243	1145	40	1	118	1	DAGLA	11	61488167	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08	42764978	61488167	73518349	27	5481											
CATSPER1	117144	broad.mit.edu	37	chr11	65793355	65793355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctcaccgtggtggggcaCgccagaggaatagtgggata	10	6	16	9	2	1	1	1	0	0	1	1	3	1	3	3	5	1	1	3	5	3	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:65793355C>T	uc001ogt.2	-	1	634	c.496G>A	c.(496-498)GTG>ATG	p.V166M		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	166	His-rich.|Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding	p.V166M(1)		ovary(2)	2						TGGTGGGGCACGCCAGAGGAA	0.582													71	75					0	0	0	0	T	65793355	T	T	65793355	3	4	27	1	0	0	0	0	1	0	0	0	2699	536	19	1	1894	1	CATSPER1	11	65793355	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08	4305188	65793355	69213161	28	5482											
PKNOX2	63876	broad.mit.edu	37	chr11	125301145	125301145	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggctatgatggctgcacacGatgactcattggatgggaca	11	9	13	8	1	1	2	1	2	0	0	1	5	1	4	0	4	1	3	0	4	1	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr11:125301145G>A	uc001qbu.2	+	13	1590	c.1276G>A	c.(1276-1278)GAT>AAT	p.D426N	PKNOX2_uc010saz.1_Missense_Mutation_p.D397N|PKNOX2_uc010sba.1_Missense_Mutation_p.D397N|PKNOX2_uc010sbb.1_Missense_Mutation_p.D362N|PKNOX2_uc001qbv.2_Missense_Mutation_p.D191N	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	426	Asp/Glu-rich (acidic).					nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		GGCTGCACACGATGACTCATT	0.388													18	29					0	0	0	0	A	125301145	A	A	125301145	3	1	27	1	0	0	0	0	1	0	0	0	12038	1058	37	1	1314	1	PKNOX2	11	125301145	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08	59507790	125301145	9705371	29	5483											
MAP3K12	7786	broad.mit.edu	37	chr12	53877172	53877172	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcttctgtggcacattcctcTtcttgataagcttctccatt	6	17	6	12	0	4	1	0	1	4	0	6	1	5	1	2	1	1	3	2	1	1	7	rs140537763		TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr12:53877172T>C	uc001sdm.1	-	11	1573	c.1475A>G	c.(1474-1476)AAG>AGG	p.K492R	MAP3K12_uc001sdn.1_Missense_Mutation_p.K525R	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	492					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						CACATTCCTCTTCTTGATAAG	0.532													127	162					0	0	0	0	C	53877172	C	C	53877172	3	2	27	1	0	0	0	0	1	0	0	0	9299	1609	56	5	1124	5	MAP3K12	12	53877172	Missense_Mutation	SNP	T	TCGA-BB-4228-01A-01D-1434-08		53877172	79974723	30	5484											
ACTN1	87	broad.mit.edu	37	chr14	69349260	69349260	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tctcattgtgctgctgtcggGcatgctcctccgtcagagct	4	13	11	13	2	2	1	2	0	1	1	6	1	4	1	2	1	4	5	2	1	0	1			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr14:69349260G>A	uc001xkl.2	-	16	2178	c.1868C>T	c.(1867-1869)GCC>GTC	p.A623V	ACTN1_uc001xkk.2_Missense_Mutation_p.A219V|ACTN1_uc010ttb.1_Missense_Mutation_p.A558V|ACTN1_uc001xkm.2_Missense_Mutation_p.A623V|ACTN1_uc001xkn.2_Missense_Mutation_p.A623V|ACTN1_uc010ttc.1_Missense_Mutation_p.A208V	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	623	Interaction with DDN.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CTGCTGTCGGGCATGCTCCTC	0.612													5	129					0	0	0	0	A	69349260	A	A	69349260	3	1	27	1	0	0	0	0	1	0	0	0	204	1203	42	4	904	4	ACTN1	14	69349260	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08		69349260	38000280	31	5485											
TRAF3	7187	broad.mit.edu	37	chr14	103363706	103363706	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agagacaaaaggaaatgcttCgaaataatgaatccaaaatc	21	7	7	6	1	0	2	0	1	0	1	3	5	1	3	1	1	1	1	1	1	8	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr14:103363706C>T	uc001ymc.1	+	10	1281	c.928C>T	c.(928-930)CGA>TGA	p.R310*	TRAF3_uc001yme.1_Nonsense_Mutation_p.R285*|TRAF3_uc001ymd.1_Nonsense_Mutation_p.R310*|TRAF3_uc010txy.1_Nonsense_Mutation_p.R227*	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	310	Potential.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		GGAAATGCTTCGAAATAATGA	0.378													27	7					0	0	0	0	T	103363706	T	T	103363706	4	4	27	1	0	0	0	0	0	1	0	0	16506	876	31	1	958	1	TRAF3	14	103363706	Nonsense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08	34014446	103363706	3985834	32	5486											
ZFYVE19	84936	broad.mit.edu	37	chr15	41102895	41102895	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcccagcagacacaggatCtgctaacgcagctggcagct	12	5	11	13	1	1	1	0	0	1	1	1	2	1	2	1	2	6	6	1	2	2	1			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr15:41102895C>T	uc001zmt.1	+	6	1280	c.766C>T	c.(766-768)CTG>TTG	p.L256L	ZFYVE19_uc001zmu.1_Silent_p.L256L|ZFYVE19_uc001zmv.1_Silent_p.L81L|ZFYVE19_uc001zmw.1_Silent_p.L81L|ZFYVE19_uc001zmx.1_Silent_p.L81L|ZFYVE19_uc010bcc.1_Silent_p.L81L	NM_001077268	NP_001070736	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	256							zinc ion binding				0		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GACACAGGATCTGCTAACGCA	0.592													2	8					0	0	0	0	T	41102895	T	T	41102895	2	4	27	1	0	0	0	0	0	0	0	1	17732	912	32	2		2	ZFYVE19	15	41102895	Silent	SNP	C	TCGA-BB-4228-01A-01D-1434-08		41102895	61428497	33	5487											
ADAL	161823	broad.mit.edu	37	chr15	43641114	43641114	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttctttagattccaaacCaaaaaaaagaaacacaaata	21	9	2	9	0	1	2	0	0	1	2	2	2	2	2	3	0	2	0	3	0	9	5			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr15:43641114C>T	uc010udo.1	+	10	1136	c.562C>T	c.(562-564)CAA>TAA	p.Q188*	ADAL_uc001zrh.2_Nonsense_Mutation_p.Q215*|ADAL_uc001zri.1_Nonsense_Mutation_p.Q100*	NM_001159280	NP_001152752	Q6DHV7	ADAL_HUMAN	adenosine deaminase-like isoform 1	215					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding				0		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GATTCCAAACCAAAAAAAAGA	0.453													36	61					0	0	0	0	T	43641114	T	T	43641114	4	4	27	1	0	0	0	0	0	1	0	0	233	595	21	4	673	4	ADAL	15	43641114	Nonsense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08	2538219	43641114	58890278	34	5488											
ITGAL	3683	broad.mit.edu	37	chr16	30522385	30522385	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcagtaacaatgaggactCagacctcctggaggacaact	14	7	10	10	0	1	2	1	1	0	1	2	5	2	5	2	3	3	2	2	3	3	1			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr16:30522385C>G	uc002dyi.3	+	24	2890	c.2714C>G	c.(2713-2715)TCA>TGA	p.S905*	ITGAL_uc002dyj.3_Nonsense_Mutation_p.S821*|ITGAL_uc010vev.1_Nonsense_Mutation_p.S139*	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	905	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	AATGAGGACTCAGACCTCCTG	0.567													53	72					0	0	0	0	G	30522385	G	G	30522385	4	3	27	1	0	0	0	0	0	1	0	0	7925	838	29	2	2808	2	ITGAL	16	30522385	Nonsense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08		30522385	59832368	35	5489											
ITGAL	3683	broad.mit.edu	37	chr16	30525152	30525152	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccccaagatccaccaagtCaagcacatgtaccaggtatg	13	6	9	13	0	1	1	1	0	0	1	2	1	2	1	5	2	2	3	5	2	5	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr16:30525152C>T	uc002dyi.3	+	25	3023	c.2847C>T	c.(2845-2847)GTC>GTT	p.V949V	ITGAL_uc002dyj.3_Silent_p.V865V|ITGAL_uc010vev.1_Silent_p.V183V	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	949	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	TCCACCAAGTCAAGCACATGT	0.507													57	74					0	0	0	0	T	30525152	T	T	30525152	2	4	27	1	0	0	0	0	0	0	0	1	7925	813	29	2		2	ITGAL	16	30525152	Silent	SNP	C	TCGA-BB-4228-01A-01D-1434-08	2767	30525152	59829601	36	5490											
EFCAB5	374786	broad.mit.edu	37	chr17	28417554	28417554	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagaggctctgggagtcctcGattttaacatcggccaaaat	11	10	11	9	2	1	1	0	0	1	1	4	4	2	2	2	3	1	1	2	3	3	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr17:28417554G>A	uc002het.2	+	20	3991	c.3799G>A	c.(3799-3801)GAT>AAT	p.D1267N	EFCAB5_uc010cse.2_Missense_Mutation_p.D1022N|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1267							calcium ion binding			ovary(1)|skin(1)	2						GGGAGTCCTCGATTTTAACAT	0.428													90	109					0	0	0	0	A	28417554	A	A	28417554	3	1	27	1	0	0	0	0	1	0	0	0	4960	1058	37	1	4044	1	EFCAB5	17	28417554	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08		28417554	52777656	37	5491											
CCDC40	55036	broad.mit.edu	37	chr17	78013852	78013852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaaatcagtgctgcagataCgacttacccgtatttcagtc	11	11	8	11	2	2	1	2	0	0	1	3	2	2	1	1	0	4	4	1	0	4	4			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr17:78013852C>T	uc010dht.2	+	3	362	c.335C>T	c.(334-336)ACG>ATG	p.T112M	CCDC40_uc010wub.1_Missense_Mutation_p.T112M	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	112					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTGCAGATACGACTTACCCG	0.483													89	115					0	0	0	0	T	78013852	T	T	78013852	3	4	27	1	0	0	0	0	1	0	0	0	2825	536	19	1	345	1	CCDC40	17	78013852	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08	49596298	78013852	3181358	38	5492											
ASPSCR1	79058	broad.mit.edu	37	chr17	79966949	79966949	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccgtggaccgggagccggtgGtgtgccaccccgacctggag	5	5	17	14	4	0	0	0	0	0	0	0	4	0	3	7	5	2	0	7	5	0	0			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr17:79966949G>T	uc002kcx.2	+	8	1067	c.970G>T	c.(970-972)GTG>TTG	p.V324L	ASPSCR1_uc002kcw.1_Missense_Mutation_p.V324L|ASPSCR1_uc002kcy.2_Missense_Mutation_p.V324L|ASPSCR1_uc002kcz.2_Missense_Mutation_p.V218L|ASPSCR1_uc002kda.2_Missense_Mutation_p.V247L|ASPSCR1_uc002kdb.1_Missense_Mutation_p.V247L	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	324	Interaction with GLUT4 (By similarity).						protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GGAGCCGGTGGTGTGCCACCC	0.721			T	TFE3	alveolar soft part sarcoma								10	3					3.07112e-06	3.16014e-06	1	0	T	79966949	T	T	79966949	3	4	27	1	0	0	0	0	1	0	0	0	1061	1261	44	4	1000	4	ASPSCR1	17	79966949	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08	1953097	79966949	1228261	39	5493											
AES	166	broad.mit.edu	37	chr19	3054133	3054133	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catactcggatgatagagttCagctcgggagcggtgacctg	9	9	14	9	3	1	3	1	2	0	1	3	5	1	5	1	3	3	2	1	3	2	3			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:3054133C>T	uc002lwy.1	-	6	530	c.357G>A	c.(355-357)CTG>CTA	p.L119L	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Silent_p.L119L|AES_uc002lxa.1_Silent_p.L63L|AES_uc002lxb.1_Silent_p.L186L|AES_uc002lxc.2_Silent_p.L186L	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	119	Gln-rich (Q domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGATAGAGTTCAGCTCGGGAG	0.657													14	17					0	0	0	0	T	3054133	T	T	3054133	2	4	27	1	0	0	0	0	0	0	0	1	352	813	29	2		2	AES	19	3054133	Silent	SNP	C	TCGA-BB-4228-01A-01D-1434-08		3054133	56074850	40	5494											
ACER1	125981	broad.mit.edu	37	chr19	6309770	6309770	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgctgttgagggcgtaggcGttgaccgtgggccgcaggaa	7	8	18	8	4	0	2	0	2	0	0	0	3	0	3	2	4	1	5	2	4	2	3			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:6309770G>A	uc002mel.2	-	4	504	c.426C>T	c.(424-426)AAC>AAT	p.N142N		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	142	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0						GGGCGTAGGCGTTGACCGTGG	0.607													81	109					0	0	0	0	A	6309770	A	A	6309770	2	1	27	1	0	0	0	0	0	0	0	1	138	1136	40	1		1	ACER1	19	6309770	Silent	SNP	G	TCGA-BB-4228-01A-01D-1434-08	3255637	6309770	52819213	41	5495											
ZNF90	7643	broad.mit.edu	37	chr19	20235931	20235931	+	RNA	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctgtggcgcactgcagaCgcggcaatggtctcatcaag	9	7	13	12	3	2	1	2	0	1	1	3	1	2	1	0	3	2	4	0	3	2	0			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:20235931C>T	uc002nos.1	+	5		c.607C>T			ZNF90_uc002not.1_RNA			Q03938	ZNF90_HUMAN	Synthetic construct DNA, clone: pF1KB9685, Homo sapiens ZNF90 gene for zinc finger protein 90, without stop codon, in Flexi system.							Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GCACTGCAGACGCGGCAATGG	0.602													20	22					0	0	0	0	T	20235931	T	T	20235931	1	4	27	0	1	0	0	0	0	0	0	0	18266	551	19	1		1	ZNF90	19	20235931	RNA	SNP	C	TCGA-BB-4228-01A-01D-1434-08	13926161	20235931	38893052	42	5496											
DMWD	1762	broad.mit.edu	37	chr19	46289911	46289911	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaggggcccctcacccacCgcccacttggccagcgggtt	5	7	12	17	2	1	1	1	1	0	0	1	1	1	1	6	4	1	1	6	4	0	3			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:46289911C>T	uc002pdj.1	-	3	889	c.843G>A	c.(841-843)GCG>GCA	p.A281A	DMWD_uc002pdk.1_Silent_p.A281A|DMWD_uc010eko.1_5'UTR	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	281					meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CCTCACCCACCGCCCACTTGG	0.677													41	54					0	0	0	0	T	46289911	T	T	46289911	2	4	27	1	0	0	0	0	0	0	0	1	4615	639	23	1		1	DMWD	19	46289911	Silent	SNP	C	TCGA-BB-4228-01A-01D-1434-08	26053980	46289911	12839072	43	5497											
ZIM2	23619	broad.mit.edu	37	chr19	57286109	57286109	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatggagttgataatgttGagtgaggtatgagggtcggc	11	11	17	2	1	0	5	0	4	0	1	1	6	0	6	0	4	0	3	0	4	3	4			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr19:57286109G>T	uc002qnr.2	-	11	1913	c.1531C>A	c.(1531-1533)CAA>AAA	p.Q511K	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_Missense_Mutation_p.Q307K|ZIM2_uc010ygr.1_Missense_Mutation_p.Q307K|ZIM2_uc002qnq.2_Missense_Mutation_p.Q511K|ZIM2_uc010etp.2_Missense_Mutation_p.Q511K|ZIM2_uc010ygs.1_Missense_Mutation_p.Q511K	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	511	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		TGATAATGTTGAGTGAGGTAT	0.423													64	66					4.83677e-39	5.2032e-39	1	0	T	57286109	T	T	57286109	3	4	27	1	0	0	0	0	1	0	0	0	17751	1299	45	2	56	2	ZIM2	19	57286109	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08	10996198	57286109	1842874	44	5498											
STK35	140901	broad.mit.edu	37	chr20	2097996	2097996	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctttgaacttgaaaccaGaatggaccaggtcacatgtg	12	10	10	9	0	1	3	1	2	0	1	1	4	1	4	3	2	3	0	3	2	3	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr20:2097996G>A	uc010gak.2	+	3	1577	c.1577G>A	c.(1576-1578)AGA>AAA	p.R526K	STK35_uc010zpu.1_Intron|STK35_uc002wfw.3_Missense_Mutation_p.R393K	NM_080836	NP_543026	Q8TDR2	STK35_HUMAN	serine/threonine kinase 35	526	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CTTGAAACCAGAATGGACCAG	0.428													65	10					0	0	0	0	A	2097996	A	A	2097996	3	1	27	1	0	0	0	0	1	0	0	0	15367	942	33	2	1587	2	STK35	20	2097996	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08		2097996	60927524	45	5499											
RIPK4	54101	broad.mit.edu	37	chr21	43161351	43161351	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagcggtgtagccgtctgAggtcatggcctccttgccag	6	9	14	12	2	2	2	1	1	1	1	3	2	3	2	4	3	3	1	4	3	1	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr21:43161351A>G	uc002yzn.1	-	8	2050	c.2002T>C	c.(2002-2004)TCA>CCA	p.S668P		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	668						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						TAGCCGTCTGAGGTCATGGCC	0.687													82	78					0	0	0	0	G	43161351	G	G	43161351	3	3	27	1	0	0	0	0	1	0	0	0	13448	304	11	5	356	5	RIPK4	21	43161351	Missense_Mutation	SNP	A	TCGA-BB-4228-01A-01D-1434-08		43161351	4968544	46	5500											
ABCG1	9619	broad.mit.edu	37	chr21	43704767	43704767	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccatccaccagcccagcGccaaactcttcgagctgttc	9	7	7	18	2	1	0	0	0	1	0	4	1	2	0	5	0	4	3	5	0	1	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr21:43704767G>A	uc002zaq.2	+	7	938	c.832G>A	c.(832-834)GCC>ACC	p.A278T	ABCG1_uc002zan.2_Missense_Mutation_p.A280T|ABCG1_uc002zam.2_Missense_Mutation_p.A256T|ABCG1_uc002zao.2_Missense_Mutation_p.A275T|ABCG1_uc002zap.2_Missense_Mutation_p.A278T|ABCG1_uc002zar.2_Missense_Mutation_p.A289T|ABCG1_uc011aev.1_Missense_Mutation_p.A289T|ABCG1_uc010gpb.1_5'Flank	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	278	Cytoplasmic (Potential).|ABC transporter.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	CCAGCCCAGCGCCAAACTCTT	0.637													7	209					0	0	0	0	A	43704767	A	A	43704767	3	1	27	1	0	0	0	0	1	0	0	0	68	1087	38	1	1026	1	ABCG1	21	43704767	Missense_Mutation	SNP	G	TCGA-BB-4228-01A-01D-1434-08	543416	43704767	4425128	47	5501											
AP1B1	162	broad.mit.edu	37	chr22	29747175	29747175	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcacctccaccttgatggcGcagcggccaatagcacgcac	9	6	9	17	3	1	1	1	1	0	0	2	1	2	1	4	2	2	3	4	2	2	2			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chr22:29747175G>A	uc003afj.2	-	9	1324	c.1140C>T	c.(1138-1140)TGC>TGT	p.C380C	AP1B1_uc003afi.2_Silent_p.C380C|AP1B1_uc003afk.2_Silent_p.C380C|AP1B1_uc003afl.2_Silent_p.C380C|AP1B1_uc011ako.1_5'Flank	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	380					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CCTTGATGGCGCAGCGGCCAA	0.547													13	482					0	0	0	0	A	29747175	A	A	29747175	2	1	27	1	0	0	0	0	0	0	0	1	731	1079	38	1		1	AP1B1	22	29747175	Silent	SNP	G	TCGA-BB-4228-01A-01D-1434-08		29747175	21557391	48	5502											
RENBP	5973	broad.mit.edu	37	chrX	153209359	153209359	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcacctacctgcttttgctgCgtccagaagctgagcatggc	7	10	11	13	1	0	2	0	1	0	1	1	2	1	2	3	1	6	5	3	1	2	3			TCGA-BB-4228-01A-01D-1434-08	TCGA-BB-4228-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd93146-1026-4362-982b-d1fc70e3c65d	6905336e-7cc4-4b72-a515-fda1b8dd7006	g.chrX:153209359C>T	uc004fjo.1	-	4	447	c.277G>A	c.(277-279)GCA>ACA	p.A93T	RENBP_uc011mzh.1_Missense_Mutation_p.A93T	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	93					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	GCTTTTGCTGCGTCCAGAAGC	0.577													6	0					0	0	0	0	T	153209359	T	T	153209359	3	4	27	1	0	0	0	0	1	0	0	0	13290	768	27	1	1038	1	RENBP	23	153209359	Missense_Mutation	SNP	C	TCGA-BB-4228-01A-01D-1434-08		153209359	2061201	49	5503											
ATAD3C	219293	broad.mit.edu	37	chr1	1390875	1390875	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcagtcgaccccaggaCgtgctggagggtgttgtgct	5	10	14	12	2	1	0	1	0	0	0	3	3	2	2	3	3	2	3	3	3	0	1	rs1781147	by1000genomes	TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr1:1390875C>T	uc001aft.2	+	5	1409	c.414C>T	c.(412-414)GAC>GAT	p.D138D		NM_001039211	NP_001034300	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	138							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GACCCCAGGACGTGCTGGAGG	0.677													11	47					0	0	0	0	T	1390875	T	T	1390875	2	4	28	1	0	0	0	0	0	0	0	1	1077	535	19	1		1	ATAD3C	1	1390875	Silent	SNP	C	TCGA-BB-7861-01A-11D-2229-08		1390875	247859746	1	5504											
MIB2	142678	broad.mit.edu	37	chr1	1565047	1565047	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcaggatgaagaagtgcatCaggtgccaggtggtcgtcag	10	7	16	8	2	2	2	2	1	0	1	3	3	2	3	1	4	2	2	1	4	2	0	rs146481628	by1000genomes	TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr1:1565047C>T	uc001agg.2	+	19	2893	c.2766C>T	c.(2764-2766)ATC>ATT	p.I922I	MIB2_uc001agh.2_Silent_p.I908I|MIB2_uc001agi.2_Silent_p.I918I|MIB2_uc001agj.2_Silent_p.I763I|MIB2_uc001agk.2_Silent_p.I857I|MIB2_uc001agm.2_Nonsense_Mutation_p.Q739*|MIB2_uc010nyq.1_Silent_p.I878I|MIB2_uc009vkh.2_Silent_p.I728I|MIB2_uc001agn.2_Silent_p.I554I|MIB2_uc001ago.2_Silent_p.I5I|MMP23B_uc001agp.2_5'Flank|MMP23B_uc001agq.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	922	RING-type 1.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGAAGTGCATCAGGTGCCAGG	0.701													9	28					0	0	0	0	T	1565047	T	T	1565047	2	4	28	1	0	0	0	0	0	0	0	1	9620	827	29	2		2	MIB2	1	1565047	Silent	SNP	C	TCGA-BB-7861-01A-11D-2229-08	174172	1565047	247685574	2	5505											
MEGF6	1953	broad.mit.edu	37	chr1	3418445	3418445	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggcccccccacaggagcaGgagctcgagcagttcacgcc	8	3	14	16	2	1	0	1	0	0	0	2	3	1	2	4	4	3	4	4	4	0	1			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr1:3418445G>A	uc001akl.2	-	18	2456	c.2229C>T	c.(2227-2229)TCC>TCT	p.S743S	MEGF6_uc001akk.2_Silent_p.S638S	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	743	EGF-like 12.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CACAGGAGCAGGAGCTCGAGC	0.687													13	63					0	0	0	0	A	3418445	A	A	3418445	2	1	28	1	0	0	0	0	0	0	0	1	9515	987	35	4		4	MEGF6	1	3418445	Silent	SNP	G	TCGA-BB-7861-01A-11D-2229-08	1853398	3418445	245832176	3	5506											
LOC649330	649330	broad.mit.edu	37	chr1	12908065	12908065	+	Frame_Shift_Del	DEL	A	-	-																															acatccgatttcttgacaacAagagtgttgagattcccaat																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr1:12908065delA	uc009vno.2	-	1	173	c.78delT	c.(76-78)CTTfs	p.L26fs	HNRNPCL1_uc010obf.1_Frame_Shift_Del_p.L26fs	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	26							nucleic acid binding|nucleotide binding				0						TCTTGACAACAAGAGTGTTGA	0.453													---	---	---								-	12908065	-	-	12908065	7	5	28	1	0	1	0	1	0	0	0	0	8935	117	5	0	807	0	LOC649330	1	12908065	Frame_Shift_Del	DEL	A	TCGA-BB-7861-01A-11D-2229-08	9489620	12908065	236342556	4	5507											
BCL9	607	broad.mit.edu	37	chr1	147091663	147091665	+	In_Frame_Del	DEL	ATG	-	-																															gcctccctggatttgcaggcAtgataaactctgaaatggaa																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr1:147091663_147091665delATG	uc001epq.2	+	8	2442_2444	c.1702_1704delATG	c.(1702-1704)ATGdel	p.M568del	BCL9_uc010ozr.1_In_Frame_Del_p.M494del	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	568	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					ATTTGCAGGCATGATAAACTCTG	0.547			T	IGH@|IGL@	B-ALL								---	---	---								-	147091665	-	-	147091663	7	5	28	1	0	1	0	1	0	0	0	0	1383	217	8	0	1720	0	BCL9	1	147091663	In_Frame_Del	DEL	ATG	TCGA-BB-7861-01A-11D-2229-08	134183598	147091663	102158958	5	5508											
HIST2H2BF	440689	broad.mit.edu	37	chr1	149398885	149398885	+	RNA	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgggcagcagcaggcgcaCggccgtctggatctcgcggg	5	4	18	14	6	2	0	0	0	2	0	3	1	2	1	2	5	2	4	2	5	0	0			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr1:149398885C>A	uc010pbi.1	-	1		c.345G>T						Q5QNW6	H2B2F_HUMAN	Homo sapiens histone cluster 2, H3, pseudogene 2, mRNA (cDNA clone IMAGE:5190019).						nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					AGCAGGCGCACGGCCGTCTGG	0.652													12	50					5.50884e-06	5.88444e-06	1	0	A	149398885	A	A	149398885	1	1	28	0	1	0	0	0	0	0	0	0	7219	536	19	3		3	HIST2H2BF	1	149398885	RNA	SNP	C	TCGA-BB-7861-01A-11D-2229-08	2307222	149398885	99851736	6	5509											
PM20D1	148811	broad.mit.edu	37	chr1	205819066	205819067	+	Frame_Shift_Del	DEL	TT	-	-																															ttcatcgcgacgcgttcctcTttgctgaactgagaagggat																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr1:205819066_205819067delTT	uc001hdj.2	-	1	179_180	c.134_135delAA	c.(133-135)AAAfs	p.K45fs	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	45						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			CGCGTTCCTCTTTGCTGAACTG	0.599													---	---	---								-	205819067	-	-	205819066	7	5	28	1	0	1	0	1	0	0	0	0	12183	1606	56	0	1425	0	PM20D1	1	205819066	Frame_Shift_Del	DEL	TT	TCGA-BB-7861-01A-11D-2229-08	56420181	205819066	43431555	7	5510											
PARP9	83666	broad.mit.edu	37	chr3	122255866	122255868	+	In_Frame_Del	DEL	ATG	-	-																															gcacaggacatttcagaaatAtgatattttctttcatttcg																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr3:122255866_122255868delATG	uc010hri.2	-	9	2068_2070	c.1923_1925delCAT	c.(1921-1926)ATCATA>ATA	p.641_642II>I	PARP9_uc003eff.3_In_Frame_Del_p.606_607II>I|PARP9_uc011bjs.1_In_Frame_Del_p.606_607II>I|PARP9_uc003efg.2_In_Frame_Del_p.186_187II>I|PARP9_uc003efi.2_In_Frame_Del_p.606_607II>I|PARP9_uc003efh.2_In_Frame_Del_p.641_642II>I|PARP9_uc003efj.2_In_Frame_Del_p.606_607II>I	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	641_642	PARP catalytic.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		TTTCAGAAATATGATATTTTCTT	0.355													---	---	---								-	122255868	-	-	122255866	7	5	28	1	0	1	0	1	0	0	0	0	11520	449	16	0	704	0	PARP9	3	122255866	In_Frame_Del	DEL	ATG	TCGA-BB-7861-01A-11D-2229-08		122255866	75766564	8	5511											
ATF6B	1388	broad.mit.edu	37	chr6	32087633	32087633	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgggcaggagtttccaggcaTaggagcgggaacgatgctct	9	7	16	9	3	1	0	0	0	1	0	2	4	2	3	1	5	3	4	1	5	2	2	rs148535194	byFrequency	TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr6:32087633T>C	uc003nzn.2	-	9	967	c.934A>G	c.(934-936)ATG>GTG	p.M312V	TNXB_uc010jts.1_5'Flank|ATF6B_uc003nzm.1_5'Flank|ATF6B_uc003nzo.2_Missense_Mutation_p.M309V|ATF6B_uc003nzp.1_Missense_Mutation_p.M1V	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	312	Cytoplasmic (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTTCCAGGCATAGGAGCGGGA	0.582													24	103					0	0	0	0	C	32087633	C	C	32087633	3	2	28	1	0	0	0	0	1	0	0	0	1087	1406	49	5	1217	5	ATF6B	6	32087633	Missense_Mutation	SNP	T	TCGA-BB-7861-01A-11D-2229-08		32087633	139027434	9	5512											
SMPD2	6610	broad.mit.edu	37	chr6	109764875	109764877	+	In_Frame_Del	DEL	GGA	-	-																															tgctgtgtgtcctggcggctGgaggaggggccggggaagct																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr6:109764875_109764877delGGA	uc003pti.2	+	10	1433_1435	c.1039_1041delGGA	c.(1039-1041)GGAdel	p.G349del	PPIL6_uc003pth.1_5'Flank	NM_003080	NP_003071	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral	349	Helical; (Potential).				induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		CCTGGCGGCTGGAGGAGGGGCCG	0.635													---	---	---								-	109764877	-	-	109764875	7	5	28	1	0	1	0	1	0	0	0	0	14869	1349	47	0	1077	0	SMPD2	6	109764875	In_Frame_Del	DEL	GGA	TCGA-BB-7861-01A-11D-2229-08	77677242	109764875	61350192	10	5513											
OR2A5	393046	broad.mit.edu	37	chr7	143747823	143747824	+	Frame_Shift_Del	DEL	CT	-	-																															atacatggcttttgctcacaCtgagtgtctcatcttggtaa																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr7:143747823_143747824delCT	uc011ktw.1	+	1	329_330	c.329_330delCT	c.(328-330)ACTfs	p.T110fs		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TTTGCTCACACTGAGTGTCTCA	0.46													---	---	---								-	143747824	-	-	143747823	7	5	28	1	0	1	0	1	0	0	0	0	11035	565	20	0	331	0	OR2A5	7	143747823	Frame_Shift_Del	DEL	CT	TCGA-BB-7861-01A-11D-2229-08		143747823	15390840	11	5514											
C7orf29	113763	broad.mit.edu	37	chr7	150028158	150028158	+	Frame_Shift_Del	DEL	C	-	-																															ctgggagaagaagcgagaagCctggccaccatctatctgtc																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr7:150028158delC	uc003wgy.2	+	1	1221	c.665delC	c.(664-666)GCCfs	p.A222fs	LRRC61_uc003wgv.2_Intron|LRRC61_uc003wgx.2_Intron|LRRC61_uc003wgw.2_Intron	NM_138434	NP_612443	Q96FA7	CG029_HUMAN	hypothetical protein LOC113763	222										ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.011)			AAGCGAGAAGCCTGGCCACCA	0.542													---	---	---								-	150028158	-	-	150028158	7	5	28	1	0	1	0	1	0	0	0	0	2396	739	26	0	667	0	C7orf29	7	150028158	Frame_Shift_Del	DEL	C	TCGA-BB-7861-01A-11D-2229-08	6280335	150028158	9110505	12	5515											
ASPH	444	broad.mit.edu	37	chr8	62559410	62559410	+	Frame_Shift_Del	DEL	T	-	-																															gtggttctcctgtgggtccaTcttcttgttgcaagtcttct																								rs80163539		TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr8:62559410delT	uc003xuj.2	-	6	787	c.518delA	c.(517-519)GATfs	p.D173fs	ASPH_uc011leg.1_Frame_Shift_Del_p.D144fs|ASPH_uc003xuo.2_Frame_Shift_Del_p.D173fs|ASPH_uc011leh.1_Frame_Shift_Del_p.D159fs|ASPH_uc003xul.2_Frame_Shift_Del_p.D159fs|ASPH_uc011lei.1_Frame_Shift_Del_p.D159fs|ASPH_uc011lej.1_Intron|ASPH_uc003xun.2_Intron|ASPH_uc011lek.1_Frame_Shift_Del_p.D173fs|ASPH_uc003xum.2_Frame_Shift_Del_p.D173fs	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	173	Glu-rich.|Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	TGTGGGTCCATCTTCTTGTTG	0.448													---	---	---								-	62559410	-	-	62559410	7	5	28	1	0	1	0	1	0	0	0	0	1055	1435	50	0	1850	0	ASPH	8	62559410	Frame_Shift_Del	DEL	T	TCGA-BB-7861-01A-11D-2229-08		62559410	83804612	13	5516											
FABP4	2167	broad.mit.edu	37	chr8	82391122	82391122	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctctctcataaactctcGtggaagtgacgcctttcatg	9	13	8	11	2	4	1	2	1	2	0	6	2	4	2	1	1	2	1	1	1	3	2			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr8:82391122G>A	uc003ycd.2	-	4	448	c.377C>T	c.(376-378)ACG>ATG	p.T126M		NM_001442	NP_001433	P15090	FABP4_HUMAN	fatty acid binding protein 4, adipocyte	126					triglyceride catabolic process	cytoplasm|nucleus|soluble fraction	fatty acid binding|protein binding|transporter activity			breast(1)	1			Epithelial(68;0.213)			ATAAACTCTCGTGGAAGTGAC	0.388													35	93					0	0	0	0	A	82391122	A	A	82391122	3	1	28	1	0	0	0	0	1	0	0	0	5387	1145	40	1	25	1	FABP4	8	82391122	Missense_Mutation	SNP	G	TCGA-BB-7861-01A-11D-2229-08	19831712	82391122	63972900	14	5517											
PGM2L1	283209	broad.mit.edu	37	chr11	74058232	74058232	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaggatttggacatttaacGgtagaaaagtctggatcagg	13	11	12	5	1	3	1	2	0	1	1	3	4	3	4	0	5	1	1	0	5	4	4			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr11:74058232G>A	uc001ovb.1	-	7	1196	c.900C>T	c.(898-900)ACC>ACT	p.T300T		NM_173582	NP_775853	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	300					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			ovary(1)	1	Breast(11;3.32e-06)					GACATTTAACGGTAGAAAAGT	0.338													16	68					0	0	0	0	A	74058232	A	A	74058232	2	1	28	1	0	0	0	0	0	0	0	1	11854	1103	39	1		1	PGM2L1	11	74058232	Silent	SNP	G	TCGA-BB-7861-01A-11D-2229-08		74058232	60948284	15	5518											
ATN1	1822	broad.mit.edu	37	chr12	7045880	7045885	+	In_Frame_Del	DEL	CAGCAA	-	-																															caacacatcaccatcaccacCagcaacagcaacagcagcag																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr12:7045880_7045885delCAGCAA	uc001qrw.1	+	5	1687_1692	c.1450_1455delCAGCAA	c.(1450-1455)CAGCAAdel	p.QQ500del	ATN1_uc001qrx.1_In_Frame_Del_p.QQ500del|ATN1_uc001qry.1_In_Frame_Del_p.QQ485del	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	500_501	Poly-Gln.				cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCATCACCACcagcaacagcaacagc	0.447													---	---	---								-	7045885	-	-	7045880	7	5	28	1	0	1	0	1	0	0	0	0	1113	595	21	0	1464	0	ATN1	12	7045880	In_Frame_Del	DEL	CAGCAA	TCGA-BB-7861-01A-11D-2229-08		7045880	126806015	16	5519											
RPL6	6128	broad.mit.edu	37	chr12	112844148	112844149	+	Splice_Site	DEL	TG	-	-																															gcttcaggaaaaccaccctcTgtaagttaaaaagaaaataa																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr12:112844148_112844149delTG	uc001ttu.2	-	5	710	c.481_splice	c.e5-1	p.R161_splice	RPL6_uc001ttv.2_Splice_Site_p.R161_splice	NM_001024662	NP_001019833	Q02878	RL6_HUMAN	ribosomal protein L6						endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			large_intestine(1)	1						AACCACCCTCTGTAAGTTAAAA	0.327													---	---	---								-	112844149	-	-	112844148	8	5	28	1	0	1	0	1	0	0	1	0	13663	1594	55	0	399	0	RPL6	12	112844148	Splice_Site	DEL	TG	TCGA-BB-7861-01A-11D-2229-08	105798268	112844148	21007747	17	5520											
C13orf39	196541	broad.mit.edu	37	chr13	103338404	103338405	+	Frame_Shift_Ins	INS	-	A	A																															tcccattttagtatccccttINSaaaaagtttgactgatgact																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr13:103338404_103338405insA	uc001vpj.2	-	4	777_778	c.771_772insT	c.(769-774)TTTAAGfs	p.F257fs	C13orf39_uc001vpk.2_Frame_Shift_Ins_p.F257fs	NM_001010977	NP_001010977	Q5VZV1	MT21C_HUMAN	hypothetical protein LOC196541	257_258							methyltransferase activity				0						AGTATCCCCTTAAAAAGTTTGA	0.351													---	---	---								A	103338405	A	A	103338404	7	5	28	1	0	1	1	0	0	0	0	0	1738	1763	61	0	26	0	C13orf39	13	103338404	Frame_Shift_Ins	INS	-	TCGA-BB-7861-01A-11D-2229-08		103338404	11831474	18	5521											
BUB1B	701	broad.mit.edu	37	chr15	40501931	40501931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcagagttgtgtatagaaGacagaccaatgcctaagttg	13	10	11	7	0	0	4	0	0	0	4	0	4	0	4	2	0	2	4	2	0	5	5			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr15:40501931G>A	uc001zkx.3	+	17	2451	c.2239G>A	c.(2239-2241)GAC>AAC	p.D747N		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	747					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GTGTATAGAAGACAGACCAAT	0.423			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				24	95					0	0	0	0	A	40501931	A	A	40501931	3	1	28	1	0	0	0	0	1	0	0	0	1576	942	33	2	2305	2	BUB1B	15	40501931	Missense_Mutation	SNP	G	TCGA-BB-7861-01A-11D-2229-08		40501931	62029461	19	5522											
IQGAP1	8826	broad.mit.edu	37	chr15	90984759	90984759	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatgctgctgttattgctaTtaatgaagctattgaccgta	11	15	8	7	1	0	2	0	2	0	0	0	2	0	2	1	0	4	6	1	0	6	7			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr15:90984759T>A	uc002bpl.1	+	8	772	c.671T>A	c.(670-672)ATT>AAT	p.I224N		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	224					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			GTTATTGCTATTAATGAAGCT	0.353													22	59					0	0	0	0	A	90984759	A	A	90984759	3	1	28	1	0	0	0	0	1	0	0	0	7853	1493	52	5	701	5	IQGAP1	15	90984759	Missense_Mutation	SNP	T	TCGA-BB-7861-01A-11D-2229-08	50482828	90984759	11546633	20	5523											
MBTPS1	8720	broad.mit.edu	37	chr16	84129399	84129399	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgggtttcattgcagggtaCtgtggggtcagctacaggca	7	10	15	9	1	2	0	2	0	0	0	2	0	2	0	1	5	4	5	1	5	2	4	rs138737600	byFrequency	TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr16:84129399C>T	uc002fhi.2	-	4	935	c.433G>A	c.(433-435)GTA>ATA	p.V145I		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	145					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						TTGCAGGGTACTGTGGGGTCA	0.557													22	107					0	0	0	0	T	84129399	T	T	84129399	3	4	28	1	0	0	0	0	1	0	0	0	9414	565	20	4	2805	4	MBTPS1	16	84129399	Missense_Mutation	SNP	C	TCGA-BB-7861-01A-11D-2229-08		84129399	6225354	21	5524											
PHF23	79142	broad.mit.edu	37	chr17	7139304	7139304	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctcgccttcactggagctGgcatctccatcttggcttgt	5	14	9	13	1	4	0	1	0	3	0	6	1	4	1	2	3	1	3	2	3	0	3			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr17:7139304G>A	uc002gfa.2	-	4	1169	c.942C>T	c.(940-942)GCC>GCT	p.A314A	DVL2_uc002gez.1_5'Flank|DVL2_uc010vtr.1_5'Flank|DVL2_uc010clz.1_5'Flank|PHF23_uc010vtt.1_Silent_p.A247A|PHF23_uc010cma.2_Silent_p.A184A	NM_024297	NP_077273	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	314							zinc ion binding				0						CACTGGAGCTGGCATCTCCAT	0.587													124	520					0	0	0	0	A	7139304	A	A	7139304	2	1	28	1	0	0	0	0	0	0	0	1	11890	1335	47	4		4	PHF23	17	7139304	Silent	SNP	G	TCGA-BB-7861-01A-11D-2229-08		7139304	74055906	22	5525											
NFATC1	4772	broad.mit.edu	37	chr18	77171332	77171332	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcgctcaaggtggagcccGtcggggaggacctgggcagc	6	5	19	11	3	1	0	1	0	0	0	2	3	1	3	2	7	2	2	2	7	1	0			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr18:77171332G>A	uc010xfg.1	+	2	1510	c.1057G>A	c.(1057-1059)GTC>ATC	p.V353I	NFATC1_uc002lnc.1_Missense_Mutation_p.V353I|NFATC1_uc010xff.1_Missense_Mutation_p.V353I|NFATC1_uc002lnd.2_Missense_Mutation_p.V353I|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Missense_Mutation_p.V353I|NFATC1_uc010xfi.1_Missense_Mutation_p.V340I|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Missense_Mutation_p.V340I|NFATC1_uc002lng.2_Missense_Mutation_p.V340I|NFATC1_uc010xfk.1_Missense_Mutation_p.V340I	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	353					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GGTGGAGCCCGTCGGGGAGGA	0.682													12	38					0	0	0	0	A	77171332	A	A	77171332	3	1	28	1	0	0	0	0	1	0	0	0	10415	1145	40	1	1155	1	NFATC1	18	77171332	Missense_Mutation	SNP	G	TCGA-BB-7861-01A-11D-2229-08		77171332	905916	23	5526											
ZFR2	23217	broad.mit.edu	37	chr19	3871980	3871980	+	5'Flank	DEL	A	-	-																															ggaatagagtgaggctctccAaaaaaaaaagaagaagaaga																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr19:3871980delA	uc002lyw.2	-						ZFR2_uc010xhx.1_5'Flank|ZFR2_uc002lyx.3_5'Flank|ZFR2_uc010xhy.1_5'Flank	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1							intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		gaggctctccaaaaaaaaaag	0.269													---	---	---								-	3871980	-	-	3871980	6	5	28	0	1	1	0	1	0	0	0	0	17727	145	5	0		0	ZFR2	19	3871980	5'Flank	DEL	A	TCGA-BB-7861-01A-11D-2229-08		3871980	55257003	24	5527											
CLIP3	25999	broad.mit.edu	37	chr19	36517641	36517641	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagaggcgcacggctgccgCggggtcccctgcgcgatagg	5	4	18	14	7	0	1	0	0	0	1	1	3	1	1	3	5	2	2	3	5	1	1			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr19:36517641C>T	uc010eeq.1	-	4	691	c.409G>A	c.(409-411)GCG>ACG	p.A137T	uc002ocy.2_Intron|CLIP3_uc002ocz.1_Missense_Mutation_p.A137T	NM_015526	NP_056341	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	137	ANK 1.				chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			ACGGCTGCCGCGGGGTCCCCT	0.672													6	15					0	0	0	0	T	36517641	T	T	36517641	3	4	28	1	0	0	0	0	1	0	0	0	3549	768	27	1	1274	1	CLIP3	19	36517641	Missense_Mutation	SNP	C	TCGA-BB-7861-01A-11D-2229-08	32645661	36517641	22611342	25	5528											
CYP2A7	1549	broad.mit.edu	37	chr19	41382568	41382568	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccagcatagggaacacttcGgtgccctggtagggaggagg	9	6	16	10	1	0	0	0	0	0	0	1	3	0	3	2	6	3	2	2	6	3	3			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr19:41382568G>A	uc002opm.2	-	8	1709	c.1167C>T	c.(1165-1167)ACC>ACT	p.T389T	CYP2A7_uc002opo.2_Silent_p.T389T|CYP2A7_uc002opn.2_Silent_p.T338T	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	389						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GGAACACTTCGGTGCCCTGGT	0.577													27	83					0	0	0	0	A	41382568	A	A	41382568	2	1	28	1	0	0	0	0	0	0	0	1	4180	1103	39	1		1	CYP2A7	19	41382568	Silent	SNP	G	TCGA-BB-7861-01A-11D-2229-08	4864927	41382568	17746415	26	5529											
PNMAL1	55228	broad.mit.edu	37	chr19	46973295	46973295	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccatcttggtctgactcaGaggcgcctcctgggctctcg	5	10	11	15	2	4	2	1	1	3	1	6	2	5	2	3	3	0	1	3	3	0	1			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr19:46973295G>A	uc002peq.3	-	2	1304	c.998C>T	c.(997-999)TCT>TTT	p.S333F	PNMAL1_uc002per.3_Missense_Mutation_p.S333F	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	333											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GTCTGACTCAGAGGCGCCTCC	0.597													74	233					0	0	0	0	A	46973295	A	A	46973295	3	1	28	1	0	0	0	0	1	0	0	0	12212	942	33	2	351	2	PNMAL1	19	46973295	Missense_Mutation	SNP	G	TCGA-BB-7861-01A-11D-2229-08	5590727	46973295	12155688	27	5530											
C20orf118	140711	broad.mit.edu	37	chr20	35509132	35509134	+	In_Frame_Del	DEL	CTC	-	-																															actggcgagacattcctcttCtccttctccccacagctgaa																										TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr20:35509132_35509134delCTC	uc002xgg.1	+	4	425_427	c.417_419delCTC	c.(415-420)TTCTCC>TTC	p.S140del		NM_080628	NP_542195	A0PJX2	CT118_HUMAN	hypothetical protein LOC140711	140	TLD.										0		Myeloproliferative disorder(115;0.00874)				CATTCCTCTTCTCCTTCTCCCCA	0.567													---	---	---								-	35509134	-	-	35509132	7	5	28	1	0	1	0	1	0	0	0	0	2094	912	32	0	431	0	C20orf118	20	35509132	In_Frame_Del	DEL	CTC	TCGA-BB-7861-01A-11D-2229-08		35509132	27516388	28	5531											
MYH9	4627	broad.mit.edu	37	chr22	36710335	36710335	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcagcttctcattggtgtaaTtgatgcacagctgctcaaac	10	12	9	10	0	2	1	2	1	1	0	3	1	2	1	0	1	5	6	0	1	2	4			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chr22:36710335T>C	uc003apg.2	-	13	1640	c.1409A>G	c.(1408-1410)AAT>AGT	p.N470S	MYH9_uc003aph.1_Missense_Mutation_p.N334S	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	470	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						ATTGGTGTAATTGATGCACAG	0.527			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				17	43					0	0	0	0	C	36710335	C	C	36710335	3	2	28	1	0	0	0	0	1	0	0	0	10095	1493	52	5	4589	5	MYH9	22	36710335	Missense_Mutation	SNP	T	TCGA-BB-7861-01A-11D-2229-08		36710335	14594231	29	5532											
TGIF2LX	90316	broad.mit.edu	37	chrX	89177312	89177312	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tataagcatcggtttaaggcCtacccttcagaagaagagaa	15	9	9	8	1	1	3	1	0	0	3	2	4	1	3	2	2	2	2	2	2	7	6			TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chrX:89177312C>G	uc004efe.2	+	2	277	c.228C>G	c.(226-228)GCC>GCG	p.A76A		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	76	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GGTTTAAGGCCTACCCTTCAG	0.468													55	62					0	0	0	0	G	89177312	G	G	89177312	2	3	28	1	0	0	0	0	0	0	0	1	15893	668	24	4		4	TGIF2LX	23	89177312	Silent	SNP	C	TCGA-BB-7861-01A-11D-2229-08		89177312	66093248	30	5533											
PLXNB3	5365	broad.mit.edu	37	chrX	153033806	153033806	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgctgaagctcgggcagccgGtcagcgccgtggcagctctc	5	7	15	14	4	2	1	1	1	1	0	4	1	2	1	2	3	5	5	2	3	1	0	rs141165767		TCGA-BB-7861-01A-11D-2229-08	TCGA-BB-7861-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	77cb5c69-f15e-45de-a060-0e8b52648209	baa74281-5ff2-4100-a721-5698c8e648b5	g.chrX:153033806G>A	uc004fii.2	+	4	1363	c.1189G>A	c.(1189-1191)GTC>ATC	p.V397I	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Missense_Mutation_p.V79I|PLXNB3_uc010nuk.2_Missense_Mutation_p.V420I|PLXNB3_uc011mzd.1_Missense_Mutation_p.V36I	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	397	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CGGGCAGCCGGTCAGCGCCGT	0.687													10	46					0	0	0	0	A	153033806	A	A	153033806	3	1	28	1	0	0	0	0	1	0	0	0	12180	1261	44	4	1317	4	PLXNB3	23	153033806	Missense_Mutation	SNP	G	TCGA-BB-7861-01A-11D-2229-08	63856494	153033806	2236754	31	5534											
NPHP4	261734	broad.mit.edu	37	chr1	5969225	5969225	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacttacccctggtcccacaGgtgagttctgcggggcagcg	6	8	14	13	2	1	1	0	1	1	0	2	2	2	1	3	4	3	2	3	4	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:5969225G>C	uc001alq.1	-	12	1756	c.1490C>G	c.(1489-1491)CCT>CGT	p.P497R	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_Intron|NPHP4_uc001alt.1_Intron	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	497					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTCCCACAGGTGAGTTCTG	0.602													4	4					0	0	0	0	C	5969225	C	C	5969225	3	2	29	1	0	0	0	0	1	0	0	0	10635	1000	35	4	2866	4	NPHP4	1	5969225	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08		5969225	243281396	1	5535											
MTOR	2475	broad.mit.edu	37	chr1	11294218	11294218	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accttcagaataggctccatGtaggggcggatgagtcgggg	9	8	16	8	2	1	2	1	1	0	1	3	3	2	3	2	6	0	2	2	6	3	3	rs148505575		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:11294218G>A	uc001asd.2	-	14	2434	c.2313C>T	c.(2311-2313)TAC>TAT	p.Y771Y		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	771					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TAGGCTCCATGTAGGGGCGGA	0.542													49	30					0	0	0	0	A	11294218	A	A	11294218	2	1	29	1	0	0	0	0	0	0	0	1	10007	1372	48	4		4	MTOR	1	11294218	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	5324993	11294218	237956403	2	5536											
PRAMEF10	343071	broad.mit.edu	37	chr1	12952809	12952809	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacagttagggcaagggaCgggaccaaagaagatcctct	13	5	13	10	1	1	2	0	0	1	2	2	4	2	4	3	3	0	2	3	3	4	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:12952809C>A	uc001auo.2	-	4	1436	c.1363G>T	c.(1363-1365)GTC>TTC	p.V455F		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	455											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCAAGGGACGGGACCAAAG	0.537													32	28					1.07637e-12	1.25165e-12	1	0	A	12952809	A	A	12952809	3	1	29	1	0	0	0	0	1	0	0	0	12486	536	19	3	65	3	PRAMEF10	1	12952809	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1658591	12952809	236297812	3	5537											
CLCNKA	1187	broad.mit.edu	37	chr1	16354523	16354523	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccccgcagtggcatctgcGgcgtcctgagctgtgcttac	5	9	12	15	3	1	1	0	1	1	0	2	1	2	1	3	2	4	4	3	2	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:16354523G>T	uc001axu.2	+	10	957	c.877G>T	c.(877-879)GGC>TGC	p.G293C	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.G293C|CLCNKA_uc010obw.1_Missense_Mutation_p.G250C|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010obx.1_5'Flank|CLCNKA_uc010oby.1_5'Flank	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	293	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	TGGCATCTGCGGCGTCCTGAG	0.582													40	24					1.30916e-28	1.73756e-28	1	0	T	16354523	T	T	16354523	3	4	29	1	0	0	0	0	1	0	0	0	3484	1116	39	3	911	3	CLCNKA	1	16354523	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	3401714	16354523	232896098	4	5538											
CSMD2	114784	broad.mit.edu	37	chr1	34066553	34066553	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgaactctgcactgttttCttggccatgctccgggtgaa	7	13	11	10	1	2	2	0	2	2	0	3	3	3	2	2	2	3	3	2	2	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:34066553C>A	uc001bxn.1	-	45	6803	c.6774G>T	c.(6772-6774)AAG>AAT	p.K2258N	CSMD2_uc001bxm.1_Missense_Mutation_p.K2256N|CSMD2_uc001bxo.1_Missense_Mutation_p.K1129N	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2258	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCACTGTTTTCTTGGCCATGC	0.547													69	71					4.09166e-32	5.51721e-32	1	0	A	34066553	A	A	34066553	3	1	29	1	0	0	0	0	1	0	0	0	3962	912	32	2	3789	2	CSMD2	1	34066553	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	17712030	34066553	215184068	5	5539											
CSMD2	114784	broad.mit.edu	37	chr1	34066577	34066577	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatgctccgggtgaagacGccgagccgtggtgctgtttg	5	9	16	11	4	0	2	0	1	0	1	1	3	1	2	4	2	3	3	4	2	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:34066577G>T	uc001bxn.1	-	45	6779	c.6750C>A	c.(6748-6750)GGC>GGA	p.G2250G	CSMD2_uc001bxm.1_Silent_p.G2248G|CSMD2_uc001bxo.1_Silent_p.G1121G	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2250	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGGTGAAGACGCCGAGCCGTG	0.582													56	60					7.10663e-31	9.53191e-31	1	0	T	34066577	T	T	34066577	2	4	29	1	0	0	0	0	0	0	0	1	3962	1074	38	3		3	CSMD2	1	34066577	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	24	34066577	215184044	6	5540											
SLC6A9	6536	broad.mit.edu	37	chr1	44474158	44474158	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaccggcgcagtcatgcgTgttccaggggttattgcagt	7	11	13	10	3	1	0	1	0	0	0	2	0	2	0	2	3	3	4	2	3	2	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:44474158T>A	uc001cll.2	-	5	868	c.676A>T	c.(676-678)ACG>TCG	p.T226S	SLC6A9_uc009vxe.2_Missense_Mutation_p.T82S|SLC6A9_uc010okm.1_Missense_Mutation_p.T153S|SLC6A9_uc001clm.2_Missense_Mutation_p.T172S|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Missense_Mutation_p.T157S|SLC6A9_uc001cln.2_Missense_Mutation_p.T153S|SLC6A9_uc010oko.1_Missense_Mutation_p.T42S|SLC6A9_uc010okp.1_RNA	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	226	Extracellular (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CAGTCATGCGTGTTCCAGGGG	0.592													54	88					0	0	0	0	A	44474158	A	A	44474158	3	1	29	1	0	0	0	0	1	0	0	0	14755	1696	59	5	1484	5	SLC6A9	1	44474158	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	10407581	44474158	204776463	7	5541											
RNF220	55182	broad.mit.edu	37	chr1	45110420	45110420	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaacccggacagtgatgctGacttggatgtggatggggat	10	9	16	6	1	0	3	0	2	0	1	0	7	0	7	1	5	2	1	1	5	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:45110420G>A	uc001clv.1	+	9	1537	c.1177G>A	c.(1177-1179)GAC>AAC	p.D393N	RNF220_uc001clw.1_Missense_Mutation_p.D393N|RNF220_uc010okx.1_Missense_Mutation_p.D154N|RNF220_uc010oky.1_Missense_Mutation_p.D180N|RNF220_uc010okz.1_Missense_Mutation_p.D135N|RNF220_uc001clx.1_Missense_Mutation_p.D109N|RNF220_uc001cly.1_Missense_Mutation_p.D72N|RNF220_uc001clz.1_Missense_Mutation_p.D72N|RNF220_uc001cma.1_Missense_Mutation_p.D72N|TMEM53_uc001cmb.1_Intron	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	393					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CAGTGATGCTGACTTGGATGT	0.592													29	74					0	0	0	0	A	45110420	A	A	45110420	3	1	29	1	0	0	0	0	1	0	0	0	13548	1290	45	2	1207	2	RNF220	1	45110420	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	636262	45110420	204140201	8	5542											
PTCH2	8643	broad.mit.edu	37	chr1	45307563	45307563	+	Frame_Shift_Del	DEL	C	-	-																															ttgtctcaataatggccatgCggagacctaatgccagggcc																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:45307563delC	uc010olf.1	-	2	233	c.221delG	c.(220-222)CGCfs	p.R74fs	PTCH2_uc010olg.1_5'UTR	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	74	Helical; (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					AATGGCCATGCGGAGACCTAA	0.537									Basal_Cell_Nevus_syndrome				---	---	---								-	45307563	-	-	45307563	7	5	29	1	0	1	0	1	0	0	0	0	12793	768	27	0	3494	0	PTCH2	1	45307563	Frame_Shift_Del	DEL	C	TCGA-BB-7862-01A-21D-2229-08	197143	45307563	203943058	9	5543											
CYP4B1	1580	broad.mit.edu	37	chr1	47282727	47282727	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgttgctggcagggatgatCtgggcaaaatgacttatctg	9	12	14	6	0	2	2	0	2	2	0	2	3	2	3	0	3	1	4	0	3	3	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:47282727C>T	uc001cqm.3	+	9	1162	c.1078C>T	c.(1078-1080)CTG>TTG	p.L360L	CYP4B1_uc001cqn.3_Silent_p.L361L|CYP4B1_uc009vym.2_Silent_p.L346L|CYP4B1_uc010omk.1_Silent_p.L197L	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	360					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CAGGGATGATCTGGGCAAAAT	0.547													48	99					0	0	0	0	T	47282727	T	T	47282727	2	4	29	1	0	0	0	0	0	0	0	1	4202	912	32	2		2	CYP4B1	1	47282727	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1975164	47282727	201967894	10	5544											
CYP4X1	260293	broad.mit.edu	37	chr1	47501491	47501491	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgccaggataagtgggagaAgatttgcagcactcaggaca	13	7	14	7	0	1	2	1	0	0	2	1	5	1	4	1	3	3	2	1	3	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:47501491A>G	uc001cqt.2	+	5	756	c.506A>G	c.(505-507)AAG>AGG	p.K169R	CYP4X1_uc001cqr.2_Missense_Mutation_p.K168R|CYP4X1_uc001cqs.2_Missense_Mutation_p.K104R	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	169						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						AAGTGGGAGAAGATTTGCAGC	0.483													20	43					0	0	0	0	G	47501491	G	G	47501491	3	3	29	1	0	0	0	0	1	0	0	0	4210	72	3	5	524	5	CYP4X1	1	47501491	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	218764	47501491	201749130	11	5545											
MYSM1	114803	broad.mit.edu	37	chr1	59165708	59165708	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccttcgatatccacatccGcctcttcagccgccatgatg	7	10	6	18	3	2	1	1	1	1	0	5	2	4	1	7	0	1	0	7	0	1	3	rs12402204		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:59165708G>A	uc009wab.1	-	1	40	c.17C>T	c.(16-18)GCG>GTG	p.A6V	MYSM1_uc001czd.2_Missense_Mutation_p.A6V	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	6					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					ATCCACATCCGCCTCTTCAGC	0.682													31	65					0	0	0	0	A	59165708	A	A	59165708	3	1	29	1	0	0	0	0	1	0	0	0	10154	1087	38	1	2549	1	MYSM1	1	59165708	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	11664217	59165708	190084913	12	5546											
C1orf87	127795	broad.mit.edu	37	chr1	60503779	60503779	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagtagcttttcataattcaCctgaaaattaaatgtaaaat	17	14	5	5	0	2	1	2	1	0	0	2	2	2	1	1	0	1	3	1	0	8	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:60503779C>T	uc001czs.1	-	6	840	c.748G>A	c.(748-750)GTG>ATG	p.V250M		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	250							calcium ion binding			ovary(1)|breast(1)	2						TCATAATTCACCTGAAAATTA	0.333													14	17					0	0	0	0	T	60503779	T	T	60503779	3	4	29	1	0	0	0	0	1	0	0	0	2074	521	18	4	920	4	C1orf87	1	60503779	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1338071	60503779	188746842	13	5547											
C1orf87	127795	broad.mit.edu	37	chr1	60505791	60505791	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacgtgacttgagttctcttCtgaccagggcaagaagaaaa	13	9	11	8	1	2	5	0	3	2	2	3	6	2	5	1	1	0	2	1	1	4	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:60505791C>T	uc001czs.1	-	5	637	c.545G>A	c.(544-546)AGA>AAA	p.R182K		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	182							calcium ion binding			ovary(1)|breast(1)	2						GAGTTCTCTTCTGACCAGGGC	0.423													30	37					0	0	0	0	T	60505791	T	T	60505791	3	4	29	1	0	0	0	0	1	0	0	0	2074	913	32	2	1127	2	C1orf87	1	60505791	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2012	60505791	188744830	14	5548											
USP1	7398	broad.mit.edu	37	chr1	62910842	62910842	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgagagtccaagacccTcacaaaagaaatcaagagtt	20	6	7	8	0	2	4	2	1	0	4	3	5	3	4	2	0	0	1	2	0	7	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:62910842T>A	uc001daj.1	+	6	1319	c.991T>A	c.(991-993)TCA>ACA	p.S331T	USP1_uc001dak.1_Missense_Mutation_p.S331T|USP1_uc001dal.1_Missense_Mutation_p.S331T	NM_001017415	NP_001017415	O94782	UBP1_HUMAN	ubiquitin specific protease 1	331					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		TCCAAGACCCTCACAAAAGAA	0.323													13	26					0	0	0	0	A	62910842	A	A	62910842	3	1	29	1	0	0	0	0	1	0	0	0	17108	1551	54	5	1009	5	USP1	1	62910842	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	2405051	62910842	186339779	15	5549											
JAK1	3716	broad.mit.edu	37	chr1	65316496	65316497	+	Frame_Shift_Del	DEL	AT	-	-																															ccgtgactcacctgcaccagAtccttcttgaggatccgatc																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:65316496_65316497delAT	uc001dbu.1	-	12	1994_1995	c.1745_1746delAT	c.(1744-1746)GATfs	p.D582fs	JAK1_uc009wam.1_Frame_Shift_Del_p.D570fs	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	582					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		CCTGCACCAGATCCTTCTTGAG	0.589			Mis		ALL								---	---	---								-	65316497	-	-	65316496	7	5	29	1	0	1	0	1	0	0	0	0	7976	330	12	0	1774	0	JAK1	1	65316496	Frame_Shift_Del	DEL	AT	TCGA-BB-7862-01A-21D-2229-08	2405654	65316496	183934125	16	5550											
LEPR	3953	broad.mit.edu	37	chr1	66062270	66062270	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaattctacaacagttatCagagaagtaagtatatttta	17	13	7	4	0	2	2	1	0	1	2	2	4	2	2	0	0	2	3	0	0	9	8			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:66062270C>A	uc001dci.2	+	7	1045	c.843C>A	c.(841-843)ATC>ATA	p.I281I	LEPR_uc001dcg.2_Silent_p.I281I|LEPR_uc001dch.2_Silent_p.I281I|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Silent_p.I281I|LEPR_uc001dck.2_Silent_p.I281I	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	281	Extracellular (Potential).|Fibronectin type-III 1.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CAACAGTTATCAGAGAAGTAA	0.328													11	18					1.5842e-08	1.73851e-08	1	0	A	66062270	A	A	66062270	2	1	29	1	0	0	0	0	0	0	0	1	8768	816	29	2		2	LEPR	1	66062270	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	745774	66062270	183188351	17	5551											
SLC44A5	204962	broad.mit.edu	37	chr1	75805305	75805305	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgaaatctgggtcatatgtCcttggatcacctgcatttaa	10	15	8	8	0	3	1	2	1	1	0	4	2	4	2	2	2	1	1	2	2	3	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:75805305C>T	uc001dgu.2	-	4	207	c.63G>A	c.(61-63)AGG>AGA	p.R21R	SLC44A5_uc001dgt.2_Silent_p.R21R|SLC44A5_uc001dgs.2_5'UTR|SLC44A5_uc001dgr.2_5'UTR|SLC44A5_uc010oqz.1_Silent_p.R60R|SLC44A5_uc010ora.1_Silent_p.R15R|SLC44A5_uc010orb.1_5'UTR	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	21	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						GGTCATATGTCCTTGGATCAC	0.328													129	233					0	0	0	0	T	75805305	T	T	75805305	2	4	29	1	0	0	0	0	0	0	0	1	14703	854	30	2		2	SLC44A5	1	75805305	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	9743035	75805305	173445316	18	5552											
COL24A1	255631	broad.mit.edu	37	chr1	86200453	86200453	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgcagtcatctgaaagcacTttaggttcaagtagagtgtt	11	14	10	6	0	3	2	2	1	1	1	3	2	3	2	0	1	2	5	0	1	4	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:86200453T>C	uc001dlj.2	-	59	5019	c.4977A>G	c.(4975-4977)AAA>AAG	p.K1659K	COL24A1_uc001dli.2_Silent_p.K774K|COL24A1_uc010osd.1_Silent_p.K959K|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1659	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTGAAAGCACTTTAGGTTCAA	0.358													57	111					0	0	0	0	C	86200453	C	C	86200453	2	2	29	1	0	0	0	0	0	0	0	1	3698	1606	56	5		5	COL24A1	1	86200453	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	10395148	86200453	163050168	19	5553											
COL11A1	1301	broad.mit.edu	37	chr1	103381186	103381186	+	Splice_Site	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taacaataacacagtacttaCgcctacacctgcttccccag	13	9	4	15	1	0	0	0	0	0	0	1	0	1	0	4	0	6	2	4	0	6	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:103381186C>G	uc001dul.2	-	50	4134	c.3816_splice	c.e50+1	p.G1272_splice	COL11A1_uc001duk.2_Splice_Site_p.G468_splice|COL11A1_uc001dum.2_Splice_Site_p.G1284_splice|COL11A1_uc001dun.2_Splice_Site_p.G1233_splice|COL11A1_uc009weh.2_Splice_Site_p.G1156_splice	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACAGTACTTACGCCTACACCT	0.388													31	39					0	0	0	0	G	103381186	G	G	103381186	5	3	29	1	0	0	0	0	0	0	1	0	3682	550	19	3	1675	3	COL11A1	1	103381186	Splice_Site	SNP	C	TCGA-BB-7862-01A-21D-2229-08	17180733	103381186	145869435	20	5554											
PDE4DIP	9659	broad.mit.edu	37	chr1	144880744	144880744	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacaccctgtgctcttaccaGgactggtggtttcctcccgt	5	12	9	15	1	1	0	0	0	1	0	3	1	3	1	4	3	2	2	4	3	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:144880744G>T	uc001elw.3	-	26	4175	c.3884C>A	c.(3883-3885)CCT>CAT	p.P1295H	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.P1251H|PDE4DIP_uc001elv.3_Missense_Mutation_p.P302H	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1295					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTCTTACCAGGACTGGTGGT	0.567			T	PDGFRB	MPD								158	275					1.4242e-99	2.05133e-99	1	0	T	144880744	T	T	144880744	3	4	29	1	0	0	0	0	1	0	0	0	11697	1000	35	4	3232	4	PDE4DIP	1	144880744	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	41499558	144880744	104369877	21	5555											
PDE4DIP	9659	broad.mit.edu	37	chr1	144918863	144918863	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctccttgtgactcagactAtggtttaggtgctggatgtt	6	16	12	7	0	1	2	1	1	0	1	2	3	2	3	1	3	2	4	1	3	2	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:144918863A>T	uc001elw.3	-	10	1614	c.1323T>A	c.(1321-1323)CAT>CAA	p.H441Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.H507Q|PDE4DIP_uc001emc.1_Missense_Mutation_p.H441Q|PDE4DIP_uc001emd.1_Missense_Mutation_p.H441Q|PDE4DIP_uc001emb.1_Missense_Mutation_p.H604Q|PDE4DIP_uc001eme.1_5'UTR|PDE4DIP_uc001emf.1_Missense_Mutation_p.H228Q	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	441	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GACTCAGACTATGGTTTAGGT	0.388			T	PDGFRB	MPD								139	595					0	0	0	0	T	144918863	T	T	144918863	3	4	29	1	0	0	0	0	1	0	0	0	11697	446	16	5	5867	5	PDE4DIP	1	144918863	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	38119	144918863	104331758	22	5556											
FLG2	388698	broad.mit.edu	37	chr1	152324044	152324044	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtatctcctgtctgtccaTgagtagttccgtgtctctca	5	16	9	11	1	4	1	1	1	3	0	8	1	6	1	3	1	0	3	3	1	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:152324044T>C	uc001ezw.3	-	3	6291	c.6218A>G	c.(6217-6219)CAT>CGT	p.H2073R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2073							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTGTCCATGAGTAGTTCC	0.532													213	482					0	0	0	0	C	152324044	C	C	152324044	3	2	29	1	0	0	0	0	1	0	0	0	5955	1464	51	5	961	5	FLG2	1	152324044	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	7405181	152324044	96926577	23	5557											
IQGAP3	128239	broad.mit.edu	37	chr1	156500967	156500967	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacttgctctctggaagcCgagagggacaggatctcctt	8	10	11	12	1	3	1	1	0	2	1	5	5	3	4	2	3	2	1	2	3	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:156500967C>A	uc001fpf.2	-	33	4251	c.4176G>T	c.(4174-4176)TCG>TCT	p.S1392S		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1392					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCTGGAAGCCGAGAGGGACA	0.582													121	74					2.30743e-64	3.28615e-64	1	0	A	156500967	A	A	156500967	2	1	29	1	0	0	0	0	0	0	0	1	7855	639	23	3		3	IQGAP3	1	156500967	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	4176923	156500967	92749654	24	5558											
APCS	325	broad.mit.edu	37	chr1	159558302	159558302	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggggcaggaacaggattcctAtgggggcaagtttgatagga	11	8	17	5	0	0	1	0	1	0	0	1	4	1	4	1	7	1	3	1	7	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:159558302A>G	uc001ftv.2	+	2	572	c.476A>G	c.(475-477)TAT>TGT	p.Y159C		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	159	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					CAGGATTCCTATGGGGGCAAG	0.498													29	12					0	0	0	0	G	159558302	G	G	159558302	3	3	29	1	0	0	0	0	1	0	0	0	767	449	16	5	482	5	APCS	1	159558302	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	3057335	159558302	89692319	25	5559											
DCAF6	55827	broad.mit.edu	37	chr1	168007626	168007626	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagataacaataatgaaaagCtgagccccaaaccagggaca	19	4	8	10	0	0	3	0	2	0	1	0	4	0	4	3	1	4	1	3	1	6	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:168007626C>T	uc001gew.2	+	11	1638	c.1396C>T	c.(1396-1398)CTG>TTG	p.L466L	DCAF6_uc001gev.2_Silent_p.L486L|DCAF6_uc001gex.2_Silent_p.L543L|DCAF6_uc010plk.1_Silent_p.L512L|DCAF6_uc001gey.2_Silent_p.L339L	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	466					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TAATGAAAAGCTGAGCCCCAA	0.323													18	37					0	0	0	0	T	168007626	T	T	168007626	2	4	29	1	0	0	0	0	0	0	0	1	4291	796	28	4		4	DCAF6	1	168007626	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	8449324	168007626	81242995	26	5560											
C1orf114	57821	broad.mit.edu	37	chr1	169391453	169391453	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttggtgagacctcatcctgCaaagatttgtcaggatcaga	11	11	10	9	0	3	3	3	1	0	3	4	5	4	4	2	2	1	1	2	2	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:169391453C>T	uc001gga.1	-	3	384	c.216G>A	c.(214-216)TTG>TTA	p.L72L	C1orf114_uc001gfz.1_Silent_p.L72L|C1orf114_uc009wvq.1_Silent_p.L72L|C1orf114_uc001ggb.2_Silent_p.L72L|C1orf114_uc001ggc.1_Silent_p.L72L	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	72											0	all_hematologic(923;0.208)					CCTCATCCTGCAAAGATTTGT	0.403													27	48					0	0	0	0	T	169391453	T	T	169391453	2	4	29	1	0	0	0	0	0	0	0	1	1996	709	25	4		4	C1orf114	1	169391453	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1383827	169391453	79859168	27	5561											
FAM5B	57795	broad.mit.edu	37	chr1	177226509	177226509	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	accatatccagatagccacgGgggccatcaaggtaatgacc	13	6	10	12	1	1	2	1	1	0	1	2	2	2	2	5	3	1	1	5	3	4	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:177226509G>T	uc001glf.2	+	4	970	c.658G>T	c.(658-660)GGG>TGG	p.G220W	FAM5B_uc010pna.1_5'UTR|FAM5B_uc001glg.2_Missense_Mutation_p.G115W	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	220						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GATAGCCACGGGGGCCATCAA	0.607													7	26					0.000274275	0.000281493	1	0	T	177226509	T	T	177226509	3	4	29	1	0	0	0	0	1	0	0	0	5625	1232	43	4	668	4	FAM5B	1	177226509	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	7835056	177226509	72024112	28	5562											
CACNA1E	777	broad.mit.edu	37	chr1	181767769	181767769	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctcagactgtggtgaggaGgagacgctcactttcgaagc	9	8	14	10	2	2	3	2	1	0	2	3	6	2	4	1	3	1	1	1	3	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:181767769G>A	uc001gow.2	+	47	6777	c.6612G>A	c.(6610-6612)GAG>GAA	p.E2204E	CACNA1E_uc009wxs.2_Silent_p.E2092E|CACNA1E_uc009wxt.2_Silent_p.E1473E	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2247	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GTGGTGAGGAGGAGACGCTCA	0.642													7	19					0	0	0	0	A	181767769	A	A	181767769	2	1	29	1	0	0	0	0	0	0	0	1	2554	991	35	4		4	CACNA1E	1	181767769	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4541260	181767769	67482852	29	5563											
HMCN1	83872	broad.mit.edu	37	chr1	186010236	186010236	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagtgaatgctgctggagAaaagcaaagggacattgacc	14	6	14	7	0	0	3	0	2	0	1	0	5	0	4	1	3	3	4	1	3	4	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:186010236A>C	uc001grq.1	+	40	6501	c.6272A>C	c.(6271-6273)GAA>GCA	p.E2091A		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2091	Ig-like C2-type 18.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GCTGCTGGAGAAAAGCAAAGG	0.438													24	79					0	0	0	0	C	186010236	C	C	186010236	3	2	29	1	0	0	0	0	1	0	0	0	7259	246	9	5	6430	5	HMCN1	1	186010236	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	4242467	186010236	63240385	30	5564											
PTGS2	5743	broad.mit.edu	37	chr1	186648537	186648537	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacactcatacatacacctCggttttgacatgggtgggaa	11	10	9	11	1	1	1	1	1	0	0	2	2	1	2	2	3	2	1	2	3	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:186648537C>T	uc001gsb.2	-	2	223	c.86G>A	c.(85-87)CGA>CAA	p.R29Q	PTGS2_uc009wyo.2_5'UTR	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	29	EGF-like.				cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	ACATACACCTCGGTTTTGACA	0.388													31	15					0	0	0	0	T	186648537	T	T	186648537	3	4	29	1	0	0	0	0	1	0	0	0	12819	884	31	1	1764	1	PTGS2	1	186648537	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	638301	186648537	62602084	31	5565											
KCNT2	343450	broad.mit.edu	37	chr1	196295847	196295847	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtatcttaaaatatacttacGggttatccaatagcagtact	14	14	6	7	1	1	0	0	0	1	0	2	0	2	0	1	1	4	4	1	1	10	8			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:196295847G>A	uc001gtd.1	-	19	2336	c.2276C>T	c.(2275-2277)CCG>CTG	p.P759L	KCNT2_uc009wyt.1_Intron|KCNT2_uc001gte.1_Missense_Mutation_p.P709L|KCNT2_uc001gtf.1_Missense_Mutation_p.P759L|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.P759L|KCNT2_uc001gth.1_Missense_Mutation_p.P280L	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	759	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						ATATACTTACGGGTTATCCAA	0.284													20	31					0	0	0	0	A	196295847	A	A	196295847	3	1	29	1	0	0	0	0	1	0	0	0	8131	1130	39	1	1171	1	KCNT2	1	196295847	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	9647310	196295847	52954774	32	5566											
ASPM	259266	broad.mit.edu	37	chr1	197053484	197053484	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgccaagcgtatccatcacCatttgaatagcttgcagggg	11	10	10	10	1	1	1	1	1	0	0	2	1	2	1	3	2	4	3	3	2	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:197053484C>A	uc001gtu.2	-	28	10661	c.10404G>T	c.(10402-10404)ATG>ATT	p.M3468I	ASPM_uc001gtv.2_Missense_Mutation_p.M1883I	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	3468					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TATCCATCACCATTTGAATAG	0.328													21	51					2.25844e-05	2.35602e-05	1	0	A	197053484	A	A	197053484	3	1	29	1	0	0	0	0	1	0	0	0	1058	594	21	4	33	4	ASPM	1	197053484	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	757637	197053484	52197137	33	5567											
CRB1	23418	broad.mit.edu	37	chr1	197390841	197390841	+	Frame_Shift_Del	DEL	T	-	-																															cagcaatggtgttgctctgcTtaacttctataatatgccat																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:197390841delT	uc001gtz.2	+	6	2018	c.1883delT	c.(1882-1884)CTTfs	p.L628fs	CRB1_uc010poz.1_Frame_Shift_Del_p.L559fs|CRB1_uc010ppa.1_Intron|CRB1_uc009wza.2_Frame_Shift_Del_p.L516fs|CRB1_uc010ppb.1_Frame_Shift_Del_p.L628fs|CRB1_uc010ppc.1_Intron|CRB1_uc010ppd.1_Frame_Shift_Del_p.L109fs|CRB1_uc001gub.1_Frame_Shift_Del_p.L277fs	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	628	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GTTGCTCTGCTTAACTTCTAT	0.428													---	---	---								-	197390841	-	-	197390841	7	5	29	1	0	1	0	1	0	0	0	0	3863	1609	56	0	1905	0	CRB1	1	197390841	Frame_Shift_Del	DEL	T	TCGA-BB-7862-01A-21D-2229-08	337357	197390841	51859780	34	5568											
CACNA1S	779	broad.mit.edu	37	chr1	201036040	201036040	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccatggagatgagggacaCggccaccaccagcaggtcca	11	4	12	14	1	0	2	0	1	0	1	2	4	2	3	5	4	1	1	5	4	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:201036040C>A	uc001gvv.2	-	20	2859	c.2632G>T	c.(2632-2634)GTG>TTG	p.V878L		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	878	III.|Helical; Name=S3 of repeat III; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATGAGGGACACGGCCACCACC	0.607													13	35					0.00010058	0.000103646	1	0	A	201036040	A	A	201036040	3	1	29	1	0	0	0	0	1	0	0	0	2559	536	19	3	3089	3	CACNA1S	1	201036040	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	3645199	201036040	48214581	35	5569											
IGFN1	91156	broad.mit.edu	37	chr1	201195238	201195238	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accagccagccctggtgcatCccccggcagcgcggtaagca	8	4	12	17	3	0	0	0	0	0	0	1	0	1	0	5	3	5	4	5	3	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:201195238C>A	uc001gwc.2	+	11	3025	c.2253C>A	c.(2251-2253)ATC>ATA	p.I751I	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CCTGGTGCATCCCCCGGCAGC	0.667													41	15					1.03325e-14	1.24727e-14	1	0	A	201195238	A	A	201195238	2	1	29	1	0	0	0	0	0	0	0	1	7629	845	30	2		2	IGFN1	1	201195238	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	159198	201195238	48055383	36	5570											
CR2	1380	broad.mit.edu	37	chr1	207649644	207649644	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atactggtggaaacatagctCgattttctcctggaatgtca	11	13	9	8	1	2	0	1	0	1	0	4	3	2	2	1	3	3	1	1	3	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:207649644C>T	uc001hfw.2	+	14	2699	c.2605C>T	c.(2605-2607)CGA>TGA	p.R869*	CR2_uc001hfv.2_Nonsense_Mutation_p.R928*|CR2_uc009xch.2_Intron	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	869	Sushi 14.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						AAACATAGCTCGATTTTCTCC	0.512													20	89					0	0	0	0	T	207649644	T	T	207649644	4	4	29	1	0	0	0	0	0	1	0	0	3857	876	31	1	2840	1	CR2	1	207649644	Nonsense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	6454406	207649644	41600977	37	5571											
USH2A	7399	broad.mit.edu	37	chr1	215956128	215956128	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagacaattgtatcttcaaGattgtctattttggtccacg	11	16	7	7	1	3	2	1	0	2	2	4	2	4	2	1	1	0	1	1	1	5	8			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:215956128G>T	uc001hku.1	-	53	10924	c.10537C>A	c.(10537-10539)CTT>ATT	p.L3513I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3513	Extracellular (Potential).|Fibronectin type-III 20.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTATCTTCAAGATTGTCTATT	0.383										HNSCC(13;0.011)			55	64					9.64103e-21	1.22814e-20	1	0	T	215956128	T	T	215956128	3	4	29	1	0	0	0	0	1	0	0	0	17104	942	33	2	5151	2	USH2A	1	215956128	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	8306484	215956128	33294493	38	5572											
USH2A	7399	broad.mit.edu	37	chr1	216040501	216040501	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtacgaagagcatatattcaTaggttgtaaacctaaaatgt	16	12	8	5	1	1	1	1	0	0	1	1	2	1	1	1	1	3	4	1	1	9	8			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:216040501T>C	uc001hku.1	-	44	9080	c.8693A>G	c.(8692-8694)TAT>TGT	p.Y2898C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2898	Extracellular (Potential).|Fibronectin type-III 15.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CATATATTCATAGGTTGTAAA	0.343										HNSCC(13;0.011)			24	56					0	0	0	0	C	216040501	C	C	216040501	3	2	29	1	0	0	0	0	1	0	0	0	17104	1406	49	5	7031	5	USH2A	1	216040501	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	84373	216040501	33210120	39	5573											
SPATA17	128153	broad.mit.edu	37	chr1	217947724	217947724	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaaaagagcctgatccatggGagctgcaattacagaaggca	15	6	12	8	0	0	3	0	1	0	2	1	5	1	4	2	2	4	3	2	2	5	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:217947724G>A	uc001hlh.1	+	7	594	c.568G>A	c.(568-570)GAG>AAG	p.E190K	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.E190K	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	190						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TGATCCATGGGAGCTGCAATT	0.393													46	33					0	0	0	0	A	217947724	A	A	217947724	3	1	29	1	0	0	0	0	1	0	0	0	15068	1175	41	2	594	2	SPATA17	1	217947724	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1907223	217947724	31302897	40	5574											
HLX	3142	broad.mit.edu	37	chr1	221053233	221053233	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctggctcccttctacgccTccaacttcagcctctggtcg	4	11	9	17	2	3	0	1	0	2	0	6	0	5	0	4	3	3	2	4	3	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:221053233T>A	uc001hmv.3	+	1	491	c.34T>A	c.(34-36)TCC>ACC	p.S12T		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	12					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		CTTCTACGCCTCCAACTTCAG	0.721													15	3					0	0	0	0	A	221053233	A	A	221053233	3	1	29	1	0	0	0	0	1	0	0	0	7255	1551	54	5	36	5	HLX	1	221053233	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	3105509	221053233	28197388	41	5575											
C1orf65	164127	broad.mit.edu	37	chr1	223568415	223568415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggacaaggtgcagcacctccGggagctcaaccacctgaggg	10	4	14	13	1	1	1	1	1	0	0	2	3	2	3	4	4	4	3	4	4	2	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:223568415G>A	uc001hoa.2	+	1	1701	c.1598G>A	c.(1597-1599)CGG>CAG	p.R533Q		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	533										central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		CAGCACCTCCGGGAGCTCAAC	0.532													101	28					0	0	0	0	A	223568415	A	A	223568415	3	1	29	1	0	0	0	0	1	0	0	0	2065	1116	39	1	1600	1	C1orf65	1	223568415	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2515182	223568415	25682206	42	5576											
JMJD4	65094	broad.mit.edu	37	chr1	227922491	227922491	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtattcctggaccccacAgtttgcaactggtacaacca	10	11	8	12	0	0	0	0	0	0	0	1	1	1	1	4	2	4	5	4	2	4	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:227922491A>C	uc001hrb.2	-	2	427	c.427T>G	c.(427-429)TGT>GGT	p.C143G	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_5'Flank|SNAP47_uc001hre.2_5'Flank|SNAP47_uc001hrf.2_5'Flank|JMJD4_uc001hrc.2_Missense_Mutation_p.C143G	NM_023007	NP_075383	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4 isoform 1	143											0		Prostate(94;0.0885)				TGGACCCCACAGTTTGCAACT	0.537													31	45					0	0	0	0	C	227922491	C	C	227922491	3	2	29	1	0	0	0	0	1	0	0	0	7990	188	7	5	984	5	JMJD4	1	227922491	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	4354076	227922491	21328130	43	5577											
HEATR1	55127	broad.mit.edu	37	chr1	236734671	236734671	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggaaatattccagcaacagTgcccaaaagtaaaagggcat	17	6	9	9	1	0	0	0	0	0	0	1	1	1	1	2	2	3	3	2	2	7	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:236734671T>C	uc001hyd.1	-	28	4053	c.3928A>G	c.(3928-3930)ACT>GCT	p.T1310A	HEATR1_uc009xgh.1_Missense_Mutation_p.T472A	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1310					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CCAGCAACAGTGCCCAAAAGT	0.413													43	29					0	0	0	0	C	236734671	C	C	236734671	3	2	29	1	0	0	0	0	1	0	0	0	7066	1696	59	5	2578	5	HEATR1	1	236734671	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	8812180	236734671	12515950	44	5578											
RYR2	6262	broad.mit.edu	37	chr1	237617718	237617718	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgctctcagcaagaaagcGaaggcttccacagtcgattt	12	9	10	10	2	1	1	1	0	1	1	4	4	2	1	1	1	3	3	1	1	3	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:237617718G>T	uc001hyl.1	+	15	1440	c.1320G>T	c.(1318-1320)GCG>GCT	p.A440A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	440	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCAAGAAAGCGAAGGCTTCCA	0.408													31	29					3.21399e-22	4.15688e-22	1	0	T	237617718	T	T	237617718	2	4	29	1	0	0	0	0	0	0	0	1	13834	1045	37	3		3	RYR2	1	237617718	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	883047	237617718	11632903	45	5579											
GREM2	64388	broad.mit.edu	37	chr1	240656338	240656338	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaccttctggattttcttGagtcggaagggtgggtccag	6	14	13	8	1	3	1	1	1	2	0	5	3	4	3	2	4	0	0	2	4	1	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:240656338G>T	uc001hys.2	-	2	718	c.438C>A	c.(436-438)CTC>CTA	p.L146L		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	146	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			GGATTTTCTTGAGTCGGAAGG	0.617													146	52					5.10563e-82	7.2917e-82	1	0	T	240656338	T	T	240656338	2	4	29	1	0	0	0	0	0	0	0	1	6801	1277	45	2		2	GREM2	1	240656338	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	3038620	240656338	8594283	46	5580											
RGS7	6000	broad.mit.edu	37	chr1	241031928	241031929	+	Frame_Shift_Ins	INS	-	A	A																															aacgctctctcttggctgtcINSaaggatcttcctttcaatct																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:241031928_241031929insA	uc001hyv.2	-	9	897_898	c.567_568insT	c.(565-570)CTTGACfs	p.L189fs	RGS7_uc010pyh.1_Frame_Shift_Ins_p.L163fs|RGS7_uc010pyj.1_Frame_Shift_Ins_p.L105fs|RGS7_uc001hyu.2_Frame_Shift_Ins_p.L189fs|RGS7_uc009xgn.1_Frame_Shift_Ins_p.L136fs|RGS7_uc001hyw.2_Frame_Shift_Ins_p.L189fs|RGS7_uc001hyt.2_Frame_Shift_Ins_p.L21fs	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	189_190					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCTTGGCTGTCAAGGATCTTCC	0.465													---	---	---								A	241031929	A	A	241031928	7	5	29	1	0	1	1	0	0	0	0	0	13375	826	29	0	935	0	RGS7	1	241031928	Frame_Shift_Ins	INS	-	TCGA-BB-7862-01A-21D-2229-08	375590	241031928	8218693	47	5581											
OR1C1	26188	broad.mit.edu	37	chr1	247920886	247920886	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caccattgaatacatgatggTtgacagagtgtcgctctcag	11	11	10	9	1	1	4	1	3	1	1	3	4	1	4	1	1	1	2	1	1	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:247920886T>A	uc010pza.1	-	1	823	c.823A>T	c.(823-825)ACC>TCC	p.T275S		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TACATGATGGTTGACAGAGTG	0.498													57	48					0	0	0	0	A	247920886	A	A	247920886	3	1	29	1	0	0	0	0	1	0	0	0	11006	1725	60	5	123	5	OR1C1	1	247920886	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	6888958	247920886	1329735	48	5582											
OR1C1	26188	broad.mit.edu	37	chr1	247921680	247921680	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccagaaggacgaattccCtgacaactgttagatttctt	11	12	8	10	1	1	3	0	1	1	2	3	5	3	4	2	1	1	1	2	1	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:247921680C>T	uc010pza.1	-	1	29	c.29G>A	c.(28-30)AGG>AAG	p.R10K		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GACGAATTCCCTGACAACTGT	0.408													24	9					0	0	0	0	T	247921680	T	T	247921680	3	4	29	1	0	0	0	0	1	0	0	0	11006	681	24	4	917	4	OR1C1	1	247921680	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	794	247921680	1328941	49	5583											
OR2AK2	391191	broad.mit.edu	37	chr1	248128997	248128997	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacgtatgtgttcttggccCttggtggaactgaagccctt	8	13	11	9	1	1	1	0	1	1	0	1	2	1	2	2	3	3	2	2	3	4	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:248128997C>A	uc010pzd.1	+	1	364	c.364C>A	c.(364-366)CTT>ATT	p.L122I	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	122	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GTTCTTGGCCCTTGGTGGAAC	0.443													202	197					8.27929e-85	1.18576e-84	1	0	A	248128997	A	A	248128997	3	1	29	1	0	0	0	0	1	0	0	0	11040	681	24	4	366	4	OR2AK2	1	248128997	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	207317	248128997	1121624	50	5584											
OR2M2	391194	broad.mit.edu	37	chr1	248343571	248343571	+	Frame_Shift_Del	DEL	C	-	-																															cagcaagtccatttctatggCtggttgtgtcacacaaattt																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:248343571delC	uc010pzf.1	+	1	284	c.284delC	c.(283-285)GCTfs	p.A95fs		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATTTCTATGGCTGGTTGTGTC	0.463													---	---	---								-	248343571	-	-	248343571	7	5	29	1	0	1	0	1	0	0	0	0	11064	797	28	0	286	0	OR2M2	1	248343571	Frame_Shift_Del	DEL	C	TCGA-BB-7862-01A-21D-2229-08	214574	248343571	907050	51	5585											
OR2M3	127062	broad.mit.edu	37	chr1	248367188	248367188	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccccaacacaggacaagatGgtgtctgtattctacaccat	12	10	7	12	0	2	1	0	0	2	1	3	2	3	2	3	2	2	1	3	2	4	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr1:248367188G>T	uc010pzg.1	+	1	819	c.819G>T	c.(817-819)ATG>ATT	p.M273I		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGGACAAGATGGTGTCTGTAT	0.493													194	51					4.64004e-97	6.66431e-97	1	0	T	248367188	T	T	248367188	3	4	29	1	0	0	0	0	1	0	0	0	11065	1348	47	4	821	4	OR2M3	1	248367188	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	23617	248367188	883433	52	5586											
GREB1	9687	broad.mit.edu	37	chr2	11728900	11728900	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aacttcccttacctctgtggGaacctgaatgacgtcgtggt	8	12	10	11	2	1	2	0	2	1	0	3	3	2	3	3	2	3	0	3	2	4	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:11728900G>C	uc002rbk.1	+	10	1488	c.1188G>C	c.(1186-1188)GGG>GGC	p.G396G	GREB1_uc002rbn.1_Silent_p.G396G|GREB1_uc002rbo.1_Silent_p.G30G	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	396						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ACCTCTGTGGGAACCTGAATG	0.572													24	65					0	0	0	0	C	11728900	C	C	11728900	2	2	29	1	0	0	0	0	0	0	0	1	6799	1161	41	2		2	GREB1	2	11728900	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08		11728900	231470473	53	5587											
IFT172	26160	broad.mit.edu	37	chr2	27670692	27670692	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcaccaggttgaagaggAcatctcgaagatcagcccag	12	7	10	12	1	3	3	2	1	1	2	5	5	4	4	3	2	1	1	3	2	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:27670692A>T	uc002rku.2	-	41	4577	c.4526T>A	c.(4525-4527)GTC>GAC	p.V1509D	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1509					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					GTTGAAGAGGACATCTCGAAG	0.458													25	68					0	0	0	0	T	27670692	T	T	27670692	3	4	29	1	0	0	0	0	1	0	0	0	7596	275	10	5	755	5	IFT172	2	27670692	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	15941792	27670692	215528681	54	5588											
C2orf71	388939	broad.mit.edu	37	chr2	29296561	29296561	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaggctggagtgtagataGgtgtaagcctgctggtgggc	8	9	19	5	0	0	2	0	0	0	2	0	4	0	3	1	5	2	4	1	5	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:29296561G>T	uc002rmt.1	-	1	567	c.567C>A	c.(565-567)ACC>ACA	p.T189T		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	189					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						AGTGTAGATAGGTGTAAGCCT	0.562													27	62					7.92952e-12	9.13697e-12	1	0	T	29296561	T	T	29296561	2	4	29	1	0	0	0	0	0	0	0	1	2201	987	35	4		4	C2orf71	2	29296561	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1625869	29296561	213902812	55	5589											
CAPN13	92291	broad.mit.edu	37	chr2	30986003	30986003	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccagcccattctccatcGcctgtgctgtatctgttggc	5	13	8	15	1	3	0	1	0	2	0	5	0	3	0	4	1	2	3	4	1	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:30986003G>A	uc002rnn.2	-	7	895	c.719C>T	c.(718-720)GCG>GTG	p.A240V	CAPN13_uc002rnp.1_Missense_Mutation_p.A240V	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	240	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					ATTCTCCATCGCCTGTGCTGT	0.522													16	22					0	0	0	0	A	30986003	A	A	30986003	3	1	29	1	0	0	0	0	1	0	0	0	2638	1087	38	1	1354	1	CAPN13	2	30986003	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1689442	30986003	212213370	56	5590											
MAP4K3	8491	broad.mit.edu	37	chr2	39499427	39499427	+	Frame_Shift_Del	DEL	G	-	-																															taaggatgtacccttaccttGgcagtattctgtcagggagt																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:39499427delG	uc002rro.2	-	26	2061	c.1970delC	c.(1969-1971)CCAfs	p.P657fs	MAP4K3_uc002rrp.2_Frame_Shift_Del_p.P636fs|MAP4K3_uc010yns.1_Frame_Shift_Del_p.P210fs	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	657	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				CCCTTACCTTGGCAGTATTCT	0.358													---	---	---								-	39499427	-	-	39499427	7	5	29	1	0	1	0	1	0	0	0	0	9314	1348	47	0	750	0	MAP4K3	2	39499427	Frame_Shift_Del	DEL	G	TCGA-BB-7862-01A-21D-2229-08	8513424	39499427	203699946	57	5591											
EPAS1	2034	broad.mit.edu	37	chr2	46574193	46574193	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgcgaacacacaagctcCtctcctcaggtaaggccagc	10	7	8	16	1	2	0	1	0	1	0	5	1	4	0	4	2	4	2	4	2	3	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:46574193C>T	uc002ruv.2	+	2	696	c.208C>T	c.(208-210)CTC>TTC	p.L70F		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	70					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			ACACAAGCTCCTCTCCTCAGG	0.602													25	66					0	0	0	0	T	46574193	T	T	46574193	3	4	29	1	0	0	0	0	1	0	0	0	5174	681	24	4	214	4	EPAS1	2	46574193	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	7074766	46574193	196625180	58	5592											
DYSF	8291	broad.mit.edu	37	chr2	71797013	71797013	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggtgtttgagaaccagacCcggcttcccggaggccagtg	8	7	15	11	2	0	2	0	1	0	2	1	5	1	3	4	4	1	2	4	4	1	2	rs148531939		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:71797013C>A	uc002sie.2	+	27	3250	c.2874C>A	c.(2872-2874)ACC>ACA	p.T958T	DYSF_uc010feg.2_Silent_p.T989T|DYSF_uc010feh.2_Silent_p.T944T|DYSF_uc002sig.3_Silent_p.T944T|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.T958T|DYSF_uc010fef.2_Silent_p.T975T|DYSF_uc010fei.2_Silent_p.T975T|DYSF_uc010fek.2_Silent_p.T976T|DYSF_uc010fej.2_Silent_p.T945T|DYSF_uc010fel.2_Silent_p.T945T|DYSF_uc010feo.2_Silent_p.T990T|DYSF_uc010fem.2_Silent_p.T959T|DYSF_uc010fen.2_Silent_p.T976T|DYSF_uc002sif.2_Silent_p.T959T	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	958	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						AGAACCAGACCCGGCTTCCCG	0.577													15	42					1.28384e-07	1.3938e-07	1	0	A	71797013	A	A	71797013	2	1	29	1	0	0	0	0	0	0	0	1	4881	610	22	4		4	DYSF	2	71797013	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	25222820	71797013	171402360	59	5593											
LRRTM4	80059	broad.mit.edu	37	chr2	77746670	77746670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattaattctttcagtctacGgatcccttgaaatgcatctt	11	16	5	9	1	4	1	1	1	3	0	5	2	5	2	1	1	2	1	1	1	4	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:77746670G>A	uc002snr.2	-	3	740	c.325C>T	c.(325-327)CGT>TGT	p.R109C	LRRTM4_uc002snq.2_Missense_Mutation_p.R109C|LRRTM4_uc002sns.2_Missense_Mutation_p.R109C|LRRTM4_uc002snt.2_Missense_Mutation_p.R110C	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	109	Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		TTCAGTCTACGGATCCCTTGA	0.398													9	34					0	0	0	0	A	77746670	A	A	77746670	3	1	29	1	0	0	0	0	1	0	0	0	9092	1116	39	1	1461	1	LRRTM4	2	77746670	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	5949657	77746670	165452703	60	5594											
CTNNA2	1496	broad.mit.edu	37	chr2	80801322	80801322	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgaacaagtagaggttgcCattgaagccctgagtgccaa	12	8	12	9	0	0	4	0	3	0	1	0	4	0	4	3	1	4	3	3	1	5	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:80801322C>A	uc010ysh.1	+	12	1781	c.1776C>A	c.(1774-1776)GCC>GCA	p.A592A	CTNNA2_uc010yse.1_Silent_p.A592A|CTNNA2_uc010ysf.1_Silent_p.A592A|CTNNA2_uc010ysg.1_Silent_p.A592A|CTNNA2_uc010ysi.1_Silent_p.A224A	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	592					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TAGAGGTTGCCATTGAAGCCC	0.478													27	75					3.73988e-18	4.68178e-18	1	0	A	80801322	A	A	80801322	2	1	29	1	0	0	0	0	0	0	0	1	4030	581	21	4		4	CTNNA2	2	80801322	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	3054652	80801322	162398051	61	5595											
CNGA3	1261	broad.mit.edu	37	chr2	99013556	99013556	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctccctggacaccctgcaGaccaggtttgcacgcctcct	6	9	8	18	1	0	1	0	0	0	1	3	2	3	2	6	2	2	3	6	2	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:99013556G>C	uc002syt.2	+	8	2340	c.1923G>C	c.(1921-1923)CAG>CAC	p.Q641H	CNGA3_uc002syu.2_Missense_Mutation_p.Q623H|CNGA3_uc010fij.2_Missense_Mutation_p.Q645H	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	641					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						ACACCCTGCAGACCAGGTTTG	0.612													9	21					0	0	0	0	C	99013556	C	C	99013556	3	2	29	1	0	0	0	0	1	0	0	0	3613	933	33	2	1949	2	CNGA3	2	99013556	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	18212234	99013556	144185817	62	5596											
AFF3	3899	broad.mit.edu	37	chr2	100209870	100209870	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttagaggggagagaagttcGttccggccaaaggggaccag	11	7	16	7	2	0	2	0	0	0	2	2	5	1	4	3	5	0	2	3	5	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:100209870G>C	uc002tag.2	-	14	2489	c.2253C>G	c.(2251-2253)AAC>AAG	p.N751K	AFF3_uc002taf.2_Missense_Mutation_p.N776K|AFF3_uc010fiq.1_Missense_Mutation_p.N751K|AFF3_uc010yvr.1_Missense_Mutation_p.N904K|AFF3_uc002tah.1_Missense_Mutation_p.N776K	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	751					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						AGAGAAGTTCGTTCCGGCCAA	0.582													16	56					0	0	0	0	C	100209870	C	C	100209870	3	2	29	1	0	0	0	0	1	0	0	0	358	1136	40	3	1471	3	AFF3	2	100209870	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1196314	100209870	142989503	63	5597											
RANBP2	5903	broad.mit.edu	37	chr2	109381511	109381511	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctgcttgtcagaatccgAgaaaacagagtctacctgct	11	10	10	10	1	2	3	1	0	1	3	3	4	3	3	2	0	5	3	2	0	4	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:109381511A>G	uc002tem.3	+	20	4642	c.4516A>G	c.(4516-4518)AGA>GGA	p.R1506G		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1506	RanBP2-type 3.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TCAGAATCCGAGAAAACAGAG	0.403													25	72					0	0	0	0	G	109381511	G	G	109381511	3	3	29	1	0	0	0	0	1	0	0	0	13093	296	11	5	4594	5	RANBP2	2	109381511	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	9171641	109381511	133817862	64	5598											
MERTK	10461	broad.mit.edu	37	chr2	112758861	112758861	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcggcgagccattgaacttaCctgtaagttgactttcattt	9	15	8	9	2	1	2	1	2	0	0	2	3	1	2	2	1	3	2	2	1	3	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:112758861C>G	uc002thk.1	+	11	1810	c.1688C>G	c.(1687-1689)ACC>AGC	p.T563S	MERTK_uc002thl.1_Missense_Mutation_p.T387S	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	563	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						ATTGAACTTACCTGTAAGTTG	0.368													20	39					0	0	0	0	G	112758861	G	G	112758861	3	3	29	1	0	0	0	0	1	0	0	0	9532	507	18	4	1730	4	MERTK	2	112758861	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	3377350	112758861	130440512	65	5599											
PCDP1	200373	broad.mit.edu	37	chr2	120395992	120395992	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcagtttctccatcacaCggtaatgtcatcaccaggct	12	10	7	12	1	4	0	3	0	1	0	5	0	4	0	2	2	1	4	2	2	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:120395992C>T	uc002tmb.2	+	21	2366	c.1274C>T	c.(1273-1275)ACG>ATG	p.T425M		NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	711						cilium	calmodulin binding				0	Colorectal(110;0.196)					CTCCATCACACGGTAATGTCA	0.537													30	77					0	0	0	0	T	120395992	T	T	120395992	3	4	29	1	0	0	0	0	1	0	0	0	11626	550	19	1	1320	1	PCDP1	2	120395992	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	7637131	120395992	122803381	66	5600											
THSD7B	80731	broad.mit.edu	37	chr2	138414380	138414380	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtccaggagactgccatttaAcagaatggtcagagtggagc	12	8	13	8	0	1	3	1	0	0	3	2	5	2	4	2	3	3	0	2	3	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:138414380A>T	uc002tva.1	+	22	4033	c.4033A>T	c.(4033-4035)ACA>TCA	p.T1345S	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTGCCATTTAACAGAATGGTC	0.468													11	13					0	0	0	0	T	138414380	T	T	138414380	3	4	29	1	0	0	0	0	1	0	0	0	15946	43	2	5	4118	5	THSD7B	2	138414380	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	18018388	138414380	104784993	67	5601											
LRP1B	53353	broad.mit.edu	37	chr2	141108534	141108534	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatttgttgatgatcgccActgtagttgaatggatatat	12	15	10	4	1	0	3	0	3	0	0	1	5	0	4	1	1	0	3	1	1	5	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:141108534A>C	uc002tvj.1	-	77	12696	c.11724T>G	c.(11722-11724)AGT>AGG	p.S3908R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3908	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GATGATCGCCACTGTAGTTGA	0.303										TSP Lung(27;0.18)			37	94					0	0	0	0	C	141108534	C	C	141108534	3	2	29	1	0	0	0	0	1	0	0	0	9005	156	6	5	2135	5	LRP1B	2	141108534	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	2694154	141108534	102090839	68	5602											
ACVR1	90	broad.mit.edu	37	chr2	158617405	158617405	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tacctaccattgctcaccatCcgcctggccacttcccacaa	9	9	4	19	1	1	0	1	0	0	0	3	0	3	0	7	1	3	1	7	1	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:158617405C>T	uc002tzm.3	-	10	1590	c.1251G>A	c.(1249-1251)CGG>CGA	p.R417R	ACVR1_uc002tzn.3_Silent_p.R417R|ACVR1_uc010fog.2_Silent_p.R417R	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	417	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	TGCTCACCATCCGCCTGGCCA	0.408													17	27					0	0	0	0	T	158617405	T	T	158617405	2	4	29	1	0	0	0	0	0	0	0	1	220	842	30	2		2	ACVR1	2	158617405	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	17508871	158617405	84581968	69	5603											
PSMD14	10213	broad.mit.edu	37	chr2	162224019	162224019	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatgctcctgcagtggacAcagcagaacaagtctatatc	13	8	9	11	0	1	2	0	0	1	2	3	3	2	3	1	1	4	3	1	1	4	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:162224019A>G	uc002ubu.2	+	4	546	c.79A>G	c.(79-81)ACA>GCA	p.T27A		NM_005805	NP_005796	O00487	PSDE_HUMAN	proteasome 26S subunit, non-ATPase 14	27	MPN.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K63-linked deubiquitination|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	endopeptidase activator activity|metal ion binding|metallopeptidase activity|proteasome binding|ubiquitin thiolesterase activity			breast(1)	1						TGCAGTGGACACAGCAGAACA	0.358													6	8					0	0	0	0	G	162224019	G	G	162224019	3	3	29	1	0	0	0	0	1	0	0	0	12759	159	6	5	85	5	PSMD14	2	162224019	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	3606614	162224019	80975354	70	5604											
TBR1	10716	broad.mit.edu	37	chr2	162280128	162280128	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgaggacccgggcgcgccctCgccgcaacgctggtttgtga	5	6	15	15	7	0	1	0	1	0	0	1	3	0	2	3	3	1	3	3	3	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:162280128C>T	uc002ubw.1	+	6	1741	c.1439C>T	c.(1438-1440)TCG>TTG	p.S480L	TBR1_uc010foy.2_Missense_Mutation_p.S193L	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	480						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GGCGCGCCCTCGCCGCAACGC	0.622													2	4					0	0	0	0	T	162280128	T	T	162280128	3	4	29	1	0	0	0	0	1	0	0	0	15713	893	31	1	1461	1	TBR1	2	162280128	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	56109	162280128	80919245	71	5605											
SCN3A	6328	broad.mit.edu	37	chr2	165946938	165946938	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagataacatctgaaattacGctgaatgatagcggcagaca	17	8	9	7	2	1	5	0	3	1	2	1	5	1	5	0	1	3	2	0	1	6	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:165946938G>T	uc002ucx.2	-	28	6217	c.5725C>A	c.(5725-5727)CGT>AGT	p.R1909S	SCN3A_uc010zcy.1_Missense_Mutation_p.R392S|SCN3A_uc002ucy.2_Missense_Mutation_p.R1860S|SCN3A_uc002ucz.2_Missense_Mutation_p.R1860S	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1909	IQ.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CTGAAATTACGCTGAATGATA	0.358													16	31					6.31663e-08	6.88716e-08	1	0	T	165946938	T	T	165946938	3	4	29	1	0	0	0	0	1	0	0	0	13983	1087	38	3	281	3	SCN3A	2	165946938	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	3666810	165946938	77252435	72	5606											
SCN7A	6332	broad.mit.edu	37	chr2	167330398	167330398	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaataaacagttggaaaaaGgtagcttatagtcaaggaat	19	9	10	3	0	1	1	1	0	0	1	1	3	1	3	0	3	2	3	0	3	10	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:167330398G>C	uc002udu.1	-	4	481	c.354C>G	c.(352-354)CCC>CCG	p.P118P	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	118	Helical; Name=S1 of repeat I; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						GTTGGAAAAAGGTAGCTTATA	0.244													28	45					0	0	0	0	C	167330398	C	C	167330398	2	2	29	1	0	0	0	0	0	0	0	1	13988	1014	35	4		4	SCN7A	2	167330398	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1383460	167330398	75868975	73	5607											
ABCB11	8647	broad.mit.edu	37	chr2	169814479	169814479	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctgtgtacttaccccaaGaatctggctgaataaaaagg	14	9	9	9	0	1	2	0	1	1	1	1	2	1	2	2	2	3	3	2	2	8	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:169814479G>C	uc002ueo.1	-	19	2464	c.2338C>G	c.(2338-2340)CTT>GTT	p.L780V	ABCB11_uc010zda.1_Missense_Mutation_p.L222V|ABCB11_uc010zdb.1_Missense_Mutation_p.L256V	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	780	Extracellular (Potential).|ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTTACCCCAAGAATCTGGCTG	0.423													14	24					0	0	0	0	C	169814479	C	C	169814479	3	2	29	1	0	0	0	0	1	0	0	0	42	942	33	2	1667	2	ABCB11	2	169814479	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2484081	169814479	73384894	74	5608											
LRP2	4036	broad.mit.edu	37	chr2	170030530	170030530	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cattagcacaccgaaactggCccggccggcaggtcctgctg	8	6	12	15	3	0	0	0	0	0	0	1	1	1	0	4	4	3	3	4	4	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:170030530C>T	uc002ues.2	-	56	11126	c.10913G>A	c.(10912-10914)GGC>GAC	p.G3638D		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3638	LDL-receptor class A 29.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCGAAACTGGCCCGGCCGGCA	0.547													25	62					0	0	0	0	T	170030530	T	T	170030530	3	4	29	1	0	0	0	0	1	0	0	0	9006	739	26	4	3150	4	LRP2	2	170030530	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	216051	170030530	73168843	75	5609											
HOXD12	3238	broad.mit.edu	37	chr2	176964836	176964836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcaggctaagttctatgcgCccgaagcggccgctgggcca	8	6	14	13	4	1	0	0	0	1	0	1	1	1	0	3	3	3	4	3	3	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:176964836C>T	uc010zev.1	+	1	307	c.307C>T	c.(307-309)CCC>TCC	p.P103S	HOXD12_uc010zew.1_Missense_Mutation_p.P103S	NM_021193	NP_067016	P35452	HXD12_HUMAN	homeobox D12	103						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		GTTCTATGCGCCCGAAGCGGC	0.692													7	14					0	0	0	0	T	176964836	T	T	176964836	3	4	29	1	0	0	0	0	1	0	0	0	7360	739	26	4	309	4	HOXD12	2	176964836	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	6934306	176964836	66234537	76	5610											
AGPS	8540	broad.mit.edu	37	chr2	178364423	178364423	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgagaaggttcttcaacaTgaaaaacaagtgtatgatat	16	11	9	5	1	2	3	1	3	1	1	2	4	2	3	0	1	2	2	0	1	7	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:178364423T>A	uc002ull.2	+	14	1487	c.1440T>A	c.(1438-1440)CAT>CAA	p.H480Q	AGPS_uc010zfb.1_Missense_Mutation_p.H390Q	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	480					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			TTCTTCAACATGAAAAACAAG	0.279													34	79					0	0	0	0	A	178364423	A	A	178364423	3	1	29	1	0	0	0	0	1	0	0	0	394	1461	51	5	1494	5	AGPS	2	178364423	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	1399587	178364423	64834950	77	5611											
TTN	7273	broad.mit.edu	37	chr2	179472265	179472265	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacgttgtctattacaacaCggtctttatccagctcccct	9	13	5	14	2	2	0	0	0	2	0	4	0	4	0	3	1	4	2	3	1	5	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:179472265C>T	uc010zfg.1	-	226	45670	c.45446G>A	c.(45445-45447)CGT>CAT	p.R15149H	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R8844H|TTN_uc010zfi.1_Missense_Mutation_p.R8777H|TTN_uc010zfj.1_Missense_Mutation_p.R8652H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16076							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTACAACACGGTCTTTATC	0.433													123	254					0	0	0	0	T	179472265	T	T	179472265	3	4	29	1	0	0	0	0	1	0	0	0	16803	536	19	1	54887	1	TTN	2	179472265	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1107842	179472265	63727108	78	5612											
TTN	7273	broad.mit.edu	37	chr2	179497260	179497260	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaactatttaccttcaatGatcagtttgccacttgtgtg	11	16	6	8	0	2	1	2	1	0	0	2	1	2	1	2	0	3	1	2	0	5	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:179497260G>A	uc010zfg.1	-	184	35993	c.35769C>T	c.(35767-35769)ATC>ATT	p.I11923I	TTN_uc010zfh.1_Silent_p.I5618I|TTN_uc010zfi.1_Silent_p.I5551I|TTN_uc010zfj.1_Silent_p.I5426I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12850							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACCTTCAATGATCAGTTTGC	0.323													14	37					0	0	0	0	A	179497260	A	A	179497260	2	1	29	1	0	0	0	0	0	0	0	1	16803	1280	45	2		2	TTN	2	179497260	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	24995	179497260	63702113	79	5613											
CCDC141	285025	broad.mit.edu	37	chr2	179702443	179702443	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cttcccctgttccattgatgCccaaaagatctgccacctgc	8	11	6	16	0	1	2	0	1	1	1	3	2	3	2	6	0	3	1	6	0	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:179702443C>A	uc002unf.1	-	13	1835	c.1778G>T	c.(1777-1779)GGC>GTC	p.G593V	CCDC141_uc002une.1_Missense_Mutation_p.G43V	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	593							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TCCATTGATGCCCAAAAGATC	0.468													34	69					1.49673e-21	1.926e-21	1	0	A	179702443	A	A	179702443	3	1	29	1	0	0	0	0	1	0	0	0	2787	739	26	4	853	4	CCDC141	2	179702443	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	205183	179702443	63496930	80	5614											
NRP2	8828	broad.mit.edu	37	chr2	206659496	206659496	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatgaatacgaggtggactGgagcaattcttcttctgcaa	12	11	11	7	1	3	2	0	1	3	1	3	5	3	4	0	3	3	2	0	3	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:206659496G>A	uc002vaw.2	+	17	3301	c.2510G>A	c.(2509-2511)TGG>TAG	p.W837*	NRP2_uc002vax.2_Nonsense_Mutation_p.W832*|NRP2_uc002vay.2_Nonsense_Mutation_p.W815*	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	837	Extracellular (Potential).				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GAGGTGGACTGGAGCAATTCT	0.532													36	67					0	0	0	0	A	206659496	A	A	206659496	4	1	29	1	0	0	0	0	0	1	0	0	10715	1357	47	4	2888	4	NRP2	2	206659496	Nonsense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	26957053	206659496	36539877	81	5615											
C2orf67	151050	broad.mit.edu	37	chr2	210968871	210968871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaaagtagggctgcttggtGacatttcaaaatcttgttcc	10	14	10	7	0	2	1	1	1	1	0	3	1	3	1	1	2	1	5	1	2	5	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:210968871G>A	uc002vds.2	-	4	1593	c.1385C>T	c.(1384-1386)TCA>TTA	p.S462L	C2orf67_uc002vdt.2_Missense_Mutation_p.S462L|C2orf67_uc002vdw.2_Missense_Mutation_p.S462L|C2orf67_uc002vdv.2_Missense_Mutation_p.S462L|C2orf67_uc002vdx.1_Missense_Mutation_p.S462L	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	462										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		GCTGCTTGGTGACATTTCAAA	0.393													17	36					0	0	0	0	A	210968871	A	A	210968871	3	1	29	1	0	0	0	0	1	0	0	0	2196	1294	45	2	1626	2	C2orf67	2	210968871	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4309375	210968871	32230502	82	5616											
ABCB6	10058	broad.mit.edu	37	chr2	220079138	220079138	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtttagcagagagtccacTgctcgtgcccgggtagcgtt	8	10	13	10	3	0	1	0	0	0	1	2	2	1	1	2	1	4	5	2	1	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:220079138T>A	uc002vkc.1	-	7	1636	c.1359A>T	c.(1357-1359)GCA>GCT	p.A453A	ABCB6_uc010fwe.1_Silent_p.A407A|ABCB6_uc010zku.1_RNA	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	453	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAGAGTCCACTGCTCGTGCCC	0.577													33	82					0	0	0	0	A	220079138	A	A	220079138	2	1	29	1	0	0	0	0	0	0	0	1	45	1567	55	5		5	ABCB6	2	220079138	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	9110267	220079138	23120235	83	5617											
PTPRN	5798	broad.mit.edu	37	chr2	220161532	220161532	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctccaccttcagttttatgCgggcatggtcatctgcacag	7	13	9	12	1	4	0	2	0	2	0	5	0	4	0	2	2	2	3	2	2	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:220161532C>G	uc002vkz.2	-	16	2338	c.2249G>C	c.(2248-2250)CGC>CCC	p.R750P	PTPRN_uc010zlc.1_Missense_Mutation_p.R660P|PTPRN_uc002vla.2_Missense_Mutation_p.R721P|uc010zld.1_5'Flank|MIR153-1_hsa-mir-153-1|MI0000463_5'Flank	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	750	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CAGTTTTATGCGGGCATGGTC	0.617													14	41					0	0	0	0	G	220161532	G	G	220161532	3	3	29	1	0	0	0	0	1	0	0	0	12872	768	27	3	722	3	PTPRN	2	220161532	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	82394	220161532	23037841	84	5618											
FARSB	10056	broad.mit.edu	37	chr2	223464699	223464699	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcaccaggaggcacatcGagcaactgcataattctgtc	11	10	8	12	1	3	0	1	0	2	0	5	2	3	1	1	2	3	3	1	2	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:223464699G>T	uc002vne.1	-	16	1601	c.1566C>A	c.(1564-1566)CTC>CTA	p.L522L	FARSB_uc010zlq.1_Silent_p.L542L|FARSB_uc002vnf.1_Silent_p.L423L	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	522					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	GAGGCACATCGAGCAACTGCA	0.453													49	119					2.53126e-37	3.48736e-37	1	0	T	223464699	T	T	223464699	2	4	29	1	0	0	0	0	0	0	0	1	5712	1045	37	3		3	FARSB	2	223464699	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	3303167	223464699	19734674	85	5619											
SCG2	7857	broad.mit.edu	37	chr2	224463478	224463478	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtttaaaggggttatcccTggaattctcttcatacatag	10	14	9	8	1	2	0	1	0	1	0	4	1	3	1	1	3	1	2	1	3	6	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:224463478T>C	uc002vnm.2	-	2	656	c.523A>G	c.(523-525)AGG>GGG	p.R175G		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	175					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		GGGTTATCCCTGGAATTCTCT	0.423													60	91					0	0	0	0	C	224463478	C	C	224463478	3	2	29	1	0	0	0	0	1	0	0	0	13956	1579	55	5	1334	5	SCG2	2	224463478	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	998779	224463478	18735895	86	5620											
CAPN10	11132	broad.mit.edu	37	chr2	241534667	241534667	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gacagtcatacttcgtggagCccagcgagcatcccgggcaa	10	6	12	13	3	1	0	1	0	0	0	3	3	2	1	2	2	4	2	2	2	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr2:241534667C>G	uc002vzk.1	+	7	1408	c.1224C>G	c.(1222-1224)AGC>AGG	p.S408R	CAPN10_uc010zoh.1_Missense_Mutation_p.S408R|CAPN10_uc002vzl.1_Missense_Mutation_p.S408R|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Missense_Mutation_p.S280R|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	408	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		CTTCGTGGAGCCCAGCGAGCA	0.652													35	65					0	0	0	0	G	241534667	G	G	241534667	3	3	29	1	0	0	0	0	1	0	0	0	2635	738	26	4	1250	4	CAPN10	2	241534667	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	17071189	241534667	1664706	87	5621											
SCN10A	6336	broad.mit.edu	37	chr3	38781085	38781085	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gactcacagtgacgatgatgCagtcaaagatattccacttc	13	10	8	10	1	2	3	2	2	0	1	4	5	3	3	1	0	1	1	1	0	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:38781085C>G	uc003ciq.2	-	14	2201	c.2201G>C	c.(2200-2202)TGC>TCC	p.C734S		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	734	Helical; Name=S3 of repeat II; (Potential).|II.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GACGATGATGCAGTCAAAGAT	0.448													21	15					0	0	0	0	G	38781085	G	G	38781085	3	3	29	1	0	0	0	0	1	0	0	0	13977	710	25	4	3725	4	SCN10A	3	38781085	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08		38781085	159241345	88	5622											
PBRM1	55193	broad.mit.edu	37	chr3	52613197	52613197	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaccattggacatttccaCagggacatcttctttttcct	8	16	5	12	0	3	0	1	0	2	0	5	2	5	2	3	2	0	0	3	2	0	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:52613197C>A	uc003des.2	-	21	3418	c.3406G>T	c.(3406-3408)GTG>TTG	p.V1136L	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.V1136L|PBRM1_uc003der.2_Missense_Mutation_p.V1104L|PBRM1_uc003det.2_Missense_Mutation_p.V1151L|PBRM1_uc003deu.2_Missense_Mutation_p.V1151L|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.V1136L|PBRM1_uc010hmk.1_Missense_Mutation_p.V1111L|PBRM1_uc003dey.2_Missense_Mutation_p.V1111L|PBRM1_uc003dez.1_Missense_Mutation_p.V1135L	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1136					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GACATTTCCACAGGGACATCT	0.423			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								25	24					8.4185e-14	9.97239e-14	1	0	A	52613197	A	A	52613197	3	1	29	1	0	0	0	0	1	0	0	0	11545	478	17	4	1534	4	PBRM1	3	52613197	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	13832112	52613197	145409233	89	5623											
MAGI1	9223	broad.mit.edu	37	chr3	65428515	65428515	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttcaatcttttcccaaccaGcaggcagttctgaaaaataa	14	11	5	11	0	3	1	1	1	2	0	4	1	4	1	2	1	2	3	2	1	5	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:65428515G>A	uc003dmn.2	-	8	1614	c.1088C>T	c.(1087-1089)GCT>GTT	p.A363V	MAGI1_uc003dmm.2_Missense_Mutation_p.A363V|MAGI1_uc003dmo.2_Missense_Mutation_p.A363V|MAGI1_uc003dmp.2_Missense_Mutation_p.A363V|MAGI1_uc010hny.2_Missense_Mutation_p.A248V	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	363	WW 2.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TTCCCAACCAGCAGGCAGTTC	0.378													32	26					0	0	0	0	A	65428515	A	A	65428515	3	1	29	1	0	0	0	0	1	0	0	0	9243	971	34	4	3598	4	MAGI1	3	65428515	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	12815318	65428515	132593915	90	5624											
TMF1	7110	broad.mit.edu	37	chr3	69073259	69073259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccttctcttcaagttcatCattttgatttgttaatttaa	10	20	3	8	0	4	1	3	1	1	0	5	1	4	1	1	0	0	2	1	0	3	9			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:69073259C>T	uc003dnn.2	-	16	3332	c.3085G>A	c.(3085-3087)GAT>AAT	p.D1029N	TMF1_uc011bfx.1_Missense_Mutation_p.D1032N	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	1029	Potential.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		TCAAGTTCATCATTTTGATTT	0.323													28	14					0	0	0	0	T	69073259	T	T	69073259	3	4	29	1	0	0	0	0	1	0	0	0	16294	826	29	2	204	2	TMF1	3	69073259	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	3644744	69073259	128949171	91	5625											
CADM2	253559	broad.mit.edu	37	chr3	86010637	86010637	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aggccagaacctgttttgtgGacaaaggatggcggagaatt	12	9	14	6	1	0	2	0	0	0	2	0	5	0	4	2	5	1	1	2	5	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:86010637G>C	uc003dqj.2	+	7	1409	c.783G>C	c.(781-783)TGG>TGC	p.W261C	CADM2_uc003dqk.2_Missense_Mutation_p.W270C|CADM2_uc003dql.2_Missense_Mutation_p.W263C	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	261	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CTGTTTTGTGGACAAAGGATG	0.348													40	45					0	0	0	0	C	86010637	C	C	86010637	3	2	29	1	0	0	0	0	1	0	0	0	2579	1183	41	2	880	2	CADM2	3	86010637	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	16937378	86010637	112011793	92	5626											
BBX	56987	broad.mit.edu	37	chr3	107492462	107492462	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagggcatgctcacctctCtgcgagctaatgttgacaga	9	10	11	11	1	2	3	1	2	1	1	3	4	2	3	1	1	3	4	1	1	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:107492462C>A	uc010hpr.2	+	11	2221	c.1894C>A	c.(1894-1896)CTG>ATG	p.L632M	BBX_uc003dwk.3_Missense_Mutation_p.L632M|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Missense_Mutation_p.L653M|BBX_uc003dwm.3_Missense_Mutation_p.L632M|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GCTCACCTCTCTGCGAGCTAA	0.413													9	22					1.58986e-06	1.68986e-06	1	0	A	107492462	A	A	107492462	3	1	29	1	0	0	0	0	1	0	0	0	1345	912	32	2	1924	2	BBX	3	107492462	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	21481825	107492462	90529968	93	5627											
GUCA1C	9626	broad.mit.edu	37	chr3	108635029	108635029	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgatgaattcttcaggactCagagtttgctggccattgag	9	14	11	7	0	3	4	2	3	1	1	3	5	3	5	1	2	1	2	1	2	1	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:108635029C>G	uc003dxj.2	-	3	455	c.387G>C	c.(385-387)CTG>CTC	p.L129L	GUCA1C_uc003dxk.2_Silent_p.L129L	NM_005459	NP_005450	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	129					signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity				0						CTTCAGGACTCAGAGTTTGCT	0.398													38	74					0	0	0	0	G	108635029	G	G	108635029	2	3	29	1	0	0	0	0	0	0	0	1	6929	813	29	2		2	GUCA1C	3	108635029	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1142567	108635029	89387401	94	5628											
DPPA2	151871	broad.mit.edu	37	chr3	109023501	109023501	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagaagtctgccatggacCacacaccacctgacgcctgg	11	5	11	14	1	1	2	0	1	1	1	1	5	1	3	5	2	1	0	5	2	1	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:109023501C>A	uc003dxo.2	-	7	922	c.675G>T	c.(673-675)GTG>GTT	p.V225V		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	225						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						TGCCATGGACCACACACCACC	0.498													14	53					0.00244969	0.00249898	1	0	A	109023501	A	A	109023501	2	1	29	1	0	0	0	0	0	0	0	1	4756	581	21	4		4	DPPA2	3	109023501	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	388472	109023501	88998929	95	5629											
LSAMP	4045	broad.mit.edu	37	chr3	115805400	115805400	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagttcttgtcttctacaacGcacctgacagagcagagtaa	12	10	9	10	1	3	3	0	1	3	2	3	4	3	3	1	0	3	4	1	0	3	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:115805400G>A	uc003ebt.2	-	2	659	c.159C>T	c.(157-159)TGC>TGT	p.C53C	LSAMP_uc011bis.1_Silent_p.C53C	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	53	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CTTCTACAACGCACCTGACAG	0.448													13	32					0	0	0	0	A	115805400	A	A	115805400	2	1	29	1	0	0	0	0	0	0	0	1	9098	1079	38	1		1	LSAMP	3	115805400	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	6781899	115805400	82217030	96	5630											
PLXNA1	5361	broad.mit.edu	37	chr3	126751566	126751566	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagatgccagccatcagcGaccaggacatgagtgcgtat	12	6	11	12	2	1	2	1	1	0	1	1	4	1	3	4	1	4	1	4	1	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:126751566G>T	uc003ejg.2	+	30	5417	c.5413G>T	c.(5413-5415)GAC>TAC	p.D1805Y	PLXNA1_uc003ejh.2_Missense_Mutation_p.D473Y	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1828	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		AGCCATCAGCGACCAGGACAT	0.612													38	77					7.61001e-30	1.01534e-29	1	0	T	126751566	T	T	126751566	3	4	29	1	0	0	0	0	1	0	0	0	12174	1058	37	3	5600	3	PLXNA1	3	126751566	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	10946166	126751566	71270864	97	5631											
EEFSEC	60678	broad.mit.edu	37	chr3	128060317	128060317	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cattacagtgggccatgaaaCagtcatgggccggttgatgt	10	10	13	8	1	1	2	1	2	0	0	1	2	1	2	2	3	2	1	2	3	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:128060317C>T	uc003eki.2	+	5	1066	c.1028C>T	c.(1027-1029)ACA>ATA	p.T343I	EEFSEC_uc003ekj.2_Missense_Mutation_p.T288I	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	343						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GGCCATGAAACAGTCATGGGC	0.502													19	35					0	0	0	0	T	128060317	T	T	128060317	3	4	29	1	0	0	0	0	1	0	0	0	4953	478	17	4	1046	4	EEFSEC	3	128060317	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1308751	128060317	69962113	98	5632											
CPNE4	131034	broad.mit.edu	37	chr3	131293958	131293958	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgatgtagtccaagaaaGaatgcatcttgtgaatctgc	13	11	9	8	0	2	4	0	2	2	2	3	4	3	4	2	0	2	2	2	0	5	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:131293958G>T	uc003eok.2	-	10	1319	c.884C>A	c.(883-885)TCT>TAT	p.S295Y	CPNE4_uc011blq.1_Missense_Mutation_p.S313Y|CPNE4_uc003eol.2_Missense_Mutation_p.S313Y|CPNE4_uc003eom.2_Missense_Mutation_p.S295Y	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	295										upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GTCCAAGAAAGAATGCATCTT	0.418													29	74					6.02846e-25	7.87739e-25	1	0	T	131293958	T	T	131293958	3	4	29	1	0	0	0	0	1	0	0	0	3829	942	33	2	817	2	CPNE4	3	131293958	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	3233641	131293958	66728472	99	5633											
CLSTN2	64084	broad.mit.edu	37	chr3	140178481	140178481	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgacggcaggcagggtgcCaaagtccccgatgggattgt	8	9	15	9	2	0	1	0	1	0	0	1	3	1	2	3	4	1	2	3	4	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:140178481C>G	uc003etn.2	+	7	1282	c.1092C>G	c.(1090-1092)GCC>GCG	p.A364A	CLSTN2_uc003etm.2_Silent_p.A364A	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	364	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GGCAGGGTGCCAAAGTCCCCG	0.577										HNSCC(16;0.037)			16	36					0	0	0	0	G	140178481	G	G	140178481	2	3	29	1	0	0	0	0	0	0	0	1	3577	581	21	4		4	CLSTN2	3	140178481	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	8884523	140178481	57843949	100	5634											
CLSTN2	64084	broad.mit.edu	37	chr3	140277487	140277487	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaatgttttcccaggtgctTtggggaagacgtatgcatca	10	12	12	7	1	1	2	1	0	0	2	2	3	2	3	1	3	2	4	1	3	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:140277487T>C	uc003etn.2	+	12	2019	c.1829T>C	c.(1828-1830)TTT>TCT	p.F610S		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	610	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CCCAGGTGCTTTGGGGAAGAC	0.527										HNSCC(16;0.037)			18	55					0	0	0	0	C	140277487	C	C	140277487	3	2	29	1	0	0	0	0	1	0	0	0	3577	1841	64	5	1875	5	CLSTN2	3	140277487	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	99006	140277487	57744943	101	5635											
HLTF	6596	broad.mit.edu	37	chr3	148793756	148793756	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaacttgatttccattcaCattgtttactttaattgcat	10	18	4	9	0	1	1	1	1	0	0	2	1	2	1	2	0	3	2	2	0	3	9			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:148793756C>T	uc003ewq.1	-	3	525	c.307G>A	c.(307-309)GTG>ATG	p.V103M	HLTF_uc003ewr.1_Missense_Mutation_p.V103M|HLTF_uc003ews.1_Missense_Mutation_p.V103M|HLTF_uc010hve.1_Missense_Mutation_p.V103M	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	103					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TTTCCATTCACATTGTTTACT	0.318													19	30					0	0	0	0	T	148793756	T	T	148793756	3	4	29	1	0	0	0	0	1	0	0	0	7254	478	17	4	2814	4	HLTF	3	148793756	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	8516269	148793756	49228674	102	5636											
GPR171	29909	broad.mit.edu	37	chr3	150916479	150916479	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaggaacaaagcatatgatgTagcccgtggtcactaaaagt	16	8	10	7	1	1	1	1	1	0	0	1	2	1	2	1	2	3	2	1	2	7	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:150916479T>C	uc003eyq.3	-	3	935	c.695A>G	c.(694-696)TAC>TGC	p.Y232C	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_013308	NP_037440	O14626	GP171_HUMAN	G protein-coupled receptor 171	232	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCATATGATGTAGCCCGTGGT	0.398													24	51					0	0	0	0	C	150916479	C	C	150916479	3	2	29	1	0	0	0	0	1	0	0	0	6706	1638	57	5	268	5	GPR171	3	150916479	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	2122723	150916479	47105951	103	5637											
P2RY13	53829	broad.mit.edu	37	chr3	151046055	151046055	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagcaaaacacacaaagaaGacagccacgacaacaaatac	22	1	7	11	1	0	2	0	0	0	2	0	4	0	3	1	1	5	1	1	1	7	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:151046055G>A	uc003eyv.2	-	2	810	c.789C>T	c.(787-789)GTC>GTT	p.V263V	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	263	Helical; Name=6; (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			ACACAAAGAAGACAGCCACGA	0.343													17	45					0	0	0	0	A	151046055	A	A	151046055	2	1	29	1	0	0	0	0	0	0	0	1	11404	929	33	2		2	P2RY13	3	151046055	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	129576	151046055	46976375	104	5638											
SI	6476	broad.mit.edu	37	chr3	164735803	164735803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aacaccatgagcattgccctCctcttccagagccatgtaat	11	10	6	14	0	1	2	0	1	1	1	3	2	3	2	5	0	4	2	5	0	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:164735803C>T	uc003fei.2	-	29	3537	c.3475G>A	c.(3475-3477)GAG>AAG	p.E1159K		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1159	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GCATTGCCCTCCTCTTCCAGA	0.323										HNSCC(35;0.089)			27	52					0	0	0	0	T	164735803	T	T	164735803	3	4	29	1	0	0	0	0	1	0	0	0	14362	864	30	2	2088	2	SI	3	164735803	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	13689748	164735803	33286627	105	5639											
SERPINI1	5274	broad.mit.edu	37	chr3	167508197	167508197	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaggagttttcaaacatGgtaactgctaaagagagcca	15	10	10	6	0	1	2	1	1	0	1	1	4	1	3	1	2	4	3	1	2	5	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:167508197G>A	uc003ffa.3	+	3	486	c.288G>A	c.(286-288)ATG>ATA	p.M96I	SERPINI1_uc003ffb.3_Missense_Mutation_p.M96I	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	96					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						TTTCAAACATGGTAACTGCTA	0.343													19	51					0	0	0	0	A	167508197	A	A	167508197	3	1	29	1	0	0	0	0	1	0	0	0	14183	1348	47	4	294	4	SERPINI1	3	167508197	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2772394	167508197	30514233	106	5640											
TBL1XR1	79718	broad.mit.edu	37	chr3	176744174	176744174	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacttactgaaccatctgatGcactggctccaactttgtct	9	14	6	12	0	2	2	0	2	2	0	3	2	3	2	2	1	5	2	2	1	4	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:176744174G>A	uc003fiw.3	-	15	1765	c.1505C>T	c.(1504-1506)GCA>GTA	p.A502V	TBL1XR1_uc003fix.3_Missense_Mutation_p.A502V|TBL1XR1_uc011bpz.1_Missense_Mutation_p.A174V	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	502	WD 8.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			ACCATCTGATGCACTGGCTCC	0.418													21	41					0	0	0	0	A	176744174	A	A	176744174	3	1	29	1	0	0	0	0	1	0	0	0	15706	1319	46	4	47	4	TBL1XR1	3	176744174	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	9235977	176744174	21278256	107	5641											
FXR1	8087	broad.mit.edu	37	chr3	180630488	180630488	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaacatggcggagctgacGgtggaggttcgcggctctaa	8	8	15	10	4	1	1	0	1	1	0	3	3	2	3	1	6	2	3	1	6	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:180630488G>T	uc003fkq.2	+	1	37	c.15G>T	c.(13-15)ACG>ACT	p.T5T	FXR1_uc003fkp.2_5'UTR|FXR1_uc003fkr.2_Silent_p.T5T|FXR1_uc011bqj.1_5'UTR|FXR1_uc003fks.2_5'UTR|FXR1_uc011bqk.1_Silent_p.T5T|FXR1_uc011bql.1_5'Flank	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	5					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			CGGAGCTGACGGTGGAGGTTC	0.458											OREG0015934	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	113	223					4.55767e-64	6.47265e-64	1	0	T	180630488	T	T	180630488	2	4	29	1	0	0	0	0	0	0	0	1	6149	1103	39	3		3	FXR1	3	180630488	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	3886314	180630488	17391942	108	5642											
CPN2	1370	broad.mit.edu	37	chr3	194062679	194062679	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcggcaggtgcgtgatggcGttgcgttgcagccacagcct	6	8	16	11	4	0	1	0	1	0	0	0	1	0	1	2	3	6	4	2	3	0	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:194062679G>A	uc003fts.2	-	2	843	c.753C>T	c.(751-753)AAC>AAT	p.N251N		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	251	LRR 7.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GCGTGATGGCGTTGCGTTGCA	0.602													28	76					0	0	0	0	A	194062679	A	A	194062679	2	1	29	1	0	0	0	0	0	0	0	1	3825	1136	40	1		1	CPN2	3	194062679	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	13432191	194062679	3959751	109	5643											
LRRC15	131578	broad.mit.edu	37	chr3	194080603	194080603	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgcagctggatggccatgagGccattgacgttggcgaagat	9	9	15	8	2	0	3	0	2	0	1	0	5	0	4	2	4	2	3	2	4	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr3:194080603G>T	uc003ftu.2	-	2	1256	c.1170C>A	c.(1168-1170)GGC>GGA	p.G390G	LRRC15_uc003ftt.2_Silent_p.G396G	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	390	LRR 15.|Extracellular (Potential).					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TGGCCATGAGGCCATTGACGT	0.562													17	21					2.48551e-13	2.91702e-13	1	0	T	194080603	T	T	194080603	2	4	29	1	0	0	0	0	0	0	0	1	9020	1190	42	4		4	LRRC15	3	194080603	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	17924	194080603	3941827	110	5644											
ZNF721	170960	broad.mit.edu	37	chr4	435690	435690	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctccagtatgaattctccTatgtacataaaggattgctg	11	14	7	9	0	2	1	0	1	2	0	4	2	2	2	2	1	2	3	2	1	6	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:435690T>A	uc003gag.2	-	3	3257	c.2566A>T	c.(2566-2568)AGG>TGG	p.R856W	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.R888W|ZNF721_uc010ibe.2_Missense_Mutation_p.R844W	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	856						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TGAATTCTCCTATGTACATAA	0.393													16	35					0	0	0	0	A	435690	A	A	435690	3	1	29	1	0	0	0	0	1	0	0	0	18189	1521	53	5	209	5	ZNF721	4	435690	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08		435690	190718586	111	5645											
MFSD7	84179	broad.mit.edu	37	chr4	680330	680330	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtctgactcaccgccgcacgGagcccgacggagtccaggat	8	5	13	15	5	2	1	1	1	1	0	3	5	3	4	4	3	1	1	4	3	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:680330G>A	uc003gay.2	-	2	342	c.285C>T	c.(283-285)CTC>CTT	p.L95L	MFSD7_uc003gaw.2_5'Flank|MFSD7_uc003gax.2_Silent_p.L95L|MFSD7_uc003gaz.2_Silent_p.L73L|MFSD7_uc003gba.2_Silent_p.L95L|MFSD7_uc003gbb.1_Silent_p.L31L	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	95					transmembrane transport	integral to membrane					0						CCGCCGCACGGAGCCCGACGG	0.657													48	91					0	0	0	0	A	680330	A	A	680330	2	1	29	1	0	0	0	0	0	0	0	1	9590	1161	41	2		2	MFSD7	4	680330	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	244640	680330	190473946	112	5646											
RGS12	6002	broad.mit.edu	37	chr4	3419261	3419261	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagggagcacggggaccaCgcagacggtttgtggggtgg	9	5	20	7	3	0	2	0	0	0	2	0	4	0	4	1	7	1	3	1	7	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:3419261C>T	uc003ggw.2	+	9	3658	c.2754C>T	c.(2752-2754)CAC>CAT	p.H918H	RGS12_uc010ics.1_Silent_p.H117H|RGS12_uc003ggv.2_Silent_p.H918H|RGS12_uc003ggy.1_Silent_p.H316H|RGS12_uc010ict.1_Silent_p.H270H|RGS12_uc003ggz.2_Silent_p.H270H|RGS12_uc010icu.1_Silent_p.H117H|RGS12_uc011bvs.1_Silent_p.H260H|RGS12_uc003gha.2_Silent_p.H260H|RGS12_uc010icv.2_Silent_p.H117H|RGS12_uc003ghb.2_Silent_p.H117H	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	918						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACGGGGACCACGCAGACGGTT	0.667													15	36					0	0	0	0	T	3419261	T	T	3419261	2	4	29	1	0	0	0	0	0	0	0	1	13360	535	19	1		1	RGS12	4	3419261	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2738931	3419261	187735015	113	5647											
MSX1	4487	broad.mit.edu	37	chr4	4864566	4864566	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtccatcgccgagcgcgCggagttctccagctcgctca	5	8	11	17	6	2	0	1	0	1	0	6	2	3	1	4	1	2	3	4	1	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:4864566C>A	uc003gif.2	+	2	843	c.608C>A	c.(607-609)GCG>GAG	p.A203E		NM_002448	NP_002439	P28360	MSX1_HUMAN	msh homeobox 1	197	Homeobox.				apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GCCGAGCGCGCGGAGTTCTCC	0.627													29	37					2.08457e-15	2.54057e-15	1	0	A	4864566	A	A	4864566	3	1	29	1	0	0	0	0	1	0	0	0	9948	768	27	3	614	3	MSX1	4	4864566	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1445305	4864566	186289710	114	5648											
EVC2	132884	broad.mit.edu	37	chr4	5696066	5696066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacttaatacttaccaggCggtgtgttataggagactct	11	13	10	7	1	1	2	0	1	1	1	1	3	1	2	1	3	3	1	1	3	6	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:5696066C>T	uc003gij.2	-	3	500	c.446G>A	c.(445-447)CGC>CAC	p.R149H	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.R69H	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	149						integral to membrane				large_intestine(3)|ovary(2)	5						ACTTACCAGGCGGTGTGTTAT	0.393													21	24					0	0	0	0	T	5696066	T	T	5696066	3	4	29	1	0	0	0	0	1	0	0	0	5310	768	27	1	3560	1	EVC2	4	5696066	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	831500	5696066	185458210	115	5649											
TLR6	10333	broad.mit.edu	37	chr4	38829447	38829447	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccagccctctaacacttCacttgatacttggtctatat	10	13	6	12	0	3	1	1	1	2	0	3	1	3	1	2	2	3	0	2	2	4	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:38829447C>A	uc003gtm.2	-	1	1714	c.1648G>T	c.(1648-1650)GAA>TAA	p.E550*	TLR6_uc010ifg.1_Nonsense_Mutation_p.E550*	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	550	LRRCT.|Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						TCTAACACTTCACTTGATACT	0.413													94	211					1.54295e-31	2.075e-31	1	0	A	38829447	A	A	38829447	4	1	29	1	0	0	0	0	0	1	0	0	16021	835	29	2	746	2	TLR6	4	38829447	Nonsense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	33133381	38829447	152324829	116	5650											
GRXCR1	389207	broad.mit.edu	37	chr4	43022383	43022383	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttaatagggtgctgagaaaAttttgtcaatgaatgaatca	15	13	10	3	0	2	3	2	3	0	1	2	4	2	3	0	1	1	2	0	1	7	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:43022383A>T	uc003gwt.2	+	3	640	c.640A>T	c.(640-642)ATT>TTT	p.I214F		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	214	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						TGCTGAGAAAATTTTGTCAAT	0.323													13	33					0	0	0	0	T	43022383	T	T	43022383	3	4	29	1	0	0	0	0	1	0	0	0	6851	101	4	5	650	5	GRXCR1	4	43022383	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	4192936	43022383	148131893	117	5651											
YIPF7	285525	broad.mit.edu	37	chr4	44638095	44638095	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggctgaggctgctcaccagCttgttgtctagaaaaagaaa	13	9	11	8	0	2	3	1	1	1	2	2	3	2	3	1	2	2	5	1	2	4	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:44638095C>T	uc010ifx.1	-	3	213	c.196G>A	c.(196-198)GCT>ACT	p.A66T	YIPF7_uc010ify.1_Missense_Mutation_p.A66T	NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	66						endoplasmic reticulum membrane|integral to membrane					0						TGCTCACCAGCTTGTTGTCTA	0.383													11	18					0	0	0	0	T	44638095	T	T	44638095	3	4	29	1	0	0	0	0	1	0	0	0	17551	797	28	4	662	4	YIPF7	4	44638095	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1615712	44638095	146516181	118	5652											
GABRA2	2555	broad.mit.edu	37	chr4	46312211	46312211	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccaaatttcagaggacAtgaatgagcatccattggga	13	9	11	8	0	1	3	1	2	0	1	2	5	2	5	2	2	2	2	2	2	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:46312211A>T	uc003gxc.3	-	5	1211	c.538T>A	c.(538-540)TGT>AGT	p.C180S	GABRA2_uc010igc.2_Missense_Mutation_p.C180S|GABRA2_uc011bzc.1_Missense_Mutation_p.C125S|GABRA2_uc003gxe.2_Missense_Mutation_p.C180S	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	180	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTCAGAGGACATGAATGAGCA	0.388													40	84					0	0	0	0	T	46312211	T	T	46312211	3	4	29	1	0	0	0	0	1	0	0	0	6195	217	8	5	837	5	GABRA2	4	46312211	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	1674116	46312211	144842065	119	5653											
TMPRSS11B	132724	broad.mit.edu	37	chr4	69095162	69095162	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcatgaaaaataatgttttgGactttccgtgtcatatatgg	12	16	8	5	1	2	1	2	1	0	0	3	2	3	2	1	2	0	1	1	2	5	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:69095162G>T	uc003hdw.3	-	8	895	c.759C>A	c.(757-759)GTC>GTA	p.V253V		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	253	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TAATGTTTTGGACTTTCCGTG	0.333													21	33					3.8784e-16	4.79598e-16	1	0	T	69095162	T	T	69095162	2	4	29	1	0	0	0	0	0	0	0	1	16306	1161	41	2		2	TMPRSS11B	4	69095162	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	22782951	69095162	122059114	120	5654											
C4orf35	85438	broad.mit.edu	37	chr4	71201383	71201383	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaggctgtccaggtcactgaTtccactattcctgaggctga	8	11	11	11	0	1	3	1	3	0	0	4	4	4	3	3	3	0	2	3	3	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:71201383T>A	uc003hff.2	+	1	713	c.627T>A	c.(625-627)GAT>GAA	p.D209E		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	209						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				AGGTCACTGATTCCACTATTC	0.438													14	24					0	0	0	0	A	71201383	A	A	71201383	3	1	29	1	0	0	0	0	1	0	0	0	2275	1490	52	5	629	5	C4orf35	4	71201383	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	2106221	71201383	119952893	121	5655											
ALB	213	broad.mit.edu	37	chr4	74280805	74280805	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttactctgtcgtgctgctgcTgagacttgccaagacatatg	8	13	10	10	1	1	2	0	1	1	2	2	3	1	2	1	0	5	3	1	0	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:74280805T>G	uc003hgs.3	+	9	1185	c.1112T>G	c.(1111-1113)CTG>CGG	p.L371R	ALB_uc003hgw.3_Missense_Mutation_p.L179R|ALB_uc011cbe.1_Missense_Mutation_p.L50R|ALB_uc003hgt.3_Missense_Mutation_p.L371R|ALB_uc010iii.2_Missense_Mutation_p.L256R|ALB_uc003hgu.3_Missense_Mutation_p.L221R|ALB_uc003hgv.3_Missense_Mutation_p.L50R|ALB_uc011cbf.1_Missense_Mutation_p.L261R|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Missense_Mutation_p.L50R	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	371	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	GTGCTGCTGCTGAGACTTGCC	0.398													37	74					0	0	0	0	G	74280805	G	G	74280805	3	3	29	1	0	0	0	0	1	0	0	0	486	1580	55	5	1146	5	ALB	4	74280805	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	3079422	74280805	116873471	122	5656											
HELQ	113510	broad.mit.edu	37	chr4	84328640	84328640	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggaagaagccacagcaccaGggaaatcagaaggcaatctt	16	5	11	9	0	2	2	1	0	1	2	2	4	2	4	2	3	2	2	2	3	5	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:84328640G>A	uc003hom.2	-	18	3451	c.3272C>T	c.(3271-3273)CCT>CTT	p.P1091L	HELQ_uc010ikb.2_Missense_Mutation_p.P1024L|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	1091							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						CACAGCACCAGGGAAATCAGA	0.363								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					11	33					0	0	0	0	A	84328640	A	A	84328640	3	1	29	1	0	0	0	0	1	0	0	0	7086	1000	35	4	37	4	HELQ	4	84328640	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	10047835	84328640	106825636	123	5657											
GPRIN3	285513	broad.mit.edu	37	chr4	90169364	90169364	+	Frame_Shift_Del	DEL	C	-	-																															cgctgacgcggctgggcctgCgtgggctggctttgacggag																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:90169364delC	uc003hsm.1	-	2	2417	c.1898delG	c.(1897-1899)CGCfs	p.R633fs		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	633										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GCTGGGCCTGCGTGGGCTGGC	0.572													---	---	---								-	90169364	-	-	90169364	7	5	29	1	0	1	0	1	0	0	0	0	6770	768	27	0	436	0	GPRIN3	4	90169364	Frame_Shift_Del	DEL	C	TCGA-BB-7862-01A-21D-2229-08	5840724	90169364	100984912	124	5658											
GRID2	2895	broad.mit.edu	37	chr4	94411878	94411878	+	Frame_Shift_Del	DEL	G	-	-																															attgttatctcatcttacacGgcaaacctcgctgctttcct																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:94411878delG	uc011cdt.1	+	12	2205	c.1947delG	c.(1945-1947)ACGfs	p.T649fs	GRID2_uc011cdu.1_Frame_Shift_Del_p.T554fs	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	649	Helical; (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CATCTTACACGGCAAACCTCG	0.438													---	---	---								-	94411878	-	-	94411878	7	5	29	1	0	1	0	1	0	0	0	0	6811	1103	39	0	1993	0	GRID2	4	94411878	Frame_Shift_Del	DEL	G	TCGA-BB-7862-01A-21D-2229-08	4242514	94411878	96742398	125	5659											
UNC5C	8633	broad.mit.edu	37	chr4	96166251	96166251	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataccctcgtccacagcggcTgttacacacagaccactccg	10	7	7	17	3	0	1	0	0	0	1	3	1	2	1	4	1	3	2	4	1	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:96166251T>C	uc003htp.1	-	6	974	c.820A>G	c.(820-822)AGC>GGC	p.S274G	UNC5C_uc010ilc.1_Missense_Mutation_p.S274G|UNC5C_uc003htq.2_Missense_Mutation_p.S274G	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	274	Extracellular (Potential).|TSP type-1 1.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CCACAGCGGCTGTTACACACA	0.517													23	37					0	0	0	0	C	96166251	C	C	96166251	3	2	29	1	0	0	0	0	1	0	0	0	17061	1580	55	5	2019	5	UNC5C	4	96166251	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	1754373	96166251	94988025	126	5660											
ANK2	287	broad.mit.edu	37	chr4	114275822	114275822	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctttgagcacaaatcagcAaaacaaaagcagccacaaga	19	5	6	11	0	2	2	1	1	1	1	2	2	2	2	1	0	5	3	1	0	6	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:114275822A>G	uc003ibe.3	+	38	6148	c.6048A>G	c.(6046-6048)GCA>GCG	p.A2016A	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Silent_p.A2031A	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1983					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACAAATCAGCAAAACAAAAGC	0.443													14	32					0	0	0	0	G	114275822	G	G	114275822	2	3	29	1	0	0	0	0	0	0	0	1	621	117	5	5		5	ANK2	4	114275822	Silent	SNP	A	TCGA-BB-7862-01A-21D-2229-08	18109571	114275822	76878454	127	5661											
ANK2	287	broad.mit.edu	37	chr4	114279247	114279247	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tactggggctgatcccctacCgctggagacatcagctgaat	9	9	11	12	1	1	3	1	2	0	1	2	4	2	3	3	3	3	3	3	3	3	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:114279247C>A	uc003ibe.3	+	38	9573	c.9473C>A	c.(9472-9474)CCG>CAG	p.P3158Q	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.P460Q|ANK2_uc011cgb.1_Missense_Mutation_p.P3173Q	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3125					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GATCCCCTACCGCTGGAGACA	0.458													18	35					3.99206e-14	4.75111e-14	1	0	A	114279247	A	A	114279247	3	1	29	1	0	0	0	0	1	0	0	0	621	652	23	3	9688	3	ANK2	4	114279247	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	3425	114279247	76875029	128	5662											
C4orf31	79625	broad.mit.edu	37	chr4	121957973	121957973	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctcacttggatttggaCagcatccagacaagagtgaa	12	11	9	9	0	2	3	1	1	2	2	4	5	3	5	1	2	1	1	1	2	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:121957973C>A	uc003idq.1	-	4	1680	c.1153G>T	c.(1153-1155)GTC>TTC	p.V385F		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	385											0						TGGATTTGGACAGCATCCAGA	0.408													27	61					7.26314e-15	8.78857e-15	1	0	A	121957973	A	A	121957973	3	1	29	1	0	0	0	0	1	0	0	0	2271	478	17	4	557	4	C4orf31	4	121957973	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	7678726	121957973	69196303	129	5663											
TRPC3	7222	broad.mit.edu	37	chr4	122825631	122825631	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cggaagtcacttcagacaacCcaaatattgaccaaaataaa	19	7	5	10	1	2	2	2	1	0	1	2	3	2	3	2	1	1	0	2	1	8	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:122825631C>G	uc003ieg.2	-	8	2173	c.2099G>C	c.(2098-2100)GGG>GCG	p.G700A	TRPC3_uc010inr.2_Missense_Mutation_p.G572A|TRPC3_uc003ief.2_Missense_Mutation_p.G627A|TRPC3_uc011cgl.1_Missense_Mutation_p.G364A	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	615	Helical; (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						TTCAGACAACCCAAATATTGA	0.303													7	23					0	0	0	0	G	122825631	G	G	122825631	3	3	29	1	0	0	0	0	1	0	0	0	16646	623	22	4	686	4	TRPC3	4	122825631	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	867658	122825631	68328645	130	5664											
TRPC3	7222	broad.mit.edu	37	chr4	122828721	122828721	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaagggagccatttatctctAgctagaaaaaagagagaaag	18	7	11	5	0	1	3	0	0	1	3	2	6	1	4	1	1	2	1	1	1	8	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:122828721A>T	uc003ieg.2	-	7	1868	c.1794T>A	c.(1792-1794)GCT>GCA	p.A598A	TRPC3_uc010inr.2_Silent_p.A470A|TRPC3_uc003ief.2_Silent_p.A525A|TRPC3_uc011cgl.1_Silent_p.A262A	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	513	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						ATTTATCTCTAGCTAGAAAAA	0.413													14	27					0	0	0	0	T	122828721	T	T	122828721	2	4	29	1	0	0	0	0	0	0	0	1	16646	434	15	5		5	TRPC3	4	122828721	Silent	SNP	A	TCGA-BB-7862-01A-21D-2229-08	3090	122828721	68325555	131	5665											
KIAA1109	84162	broad.mit.edu	37	chr4	123274986	123274986	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taggctccagtgatcattctAcatatattgtacaaacacta	14	13	5	9	0	2	1	1	1	1	0	3	1	3	1	1	1	3	2	1	1	7	8			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:123274986A>T	uc003ieh.2	+	80	14164	c.14119A>T	c.(14119-14121)ACA>TCA	p.T4707S	KIAA1109_uc003iem.2_Missense_Mutation_p.T1063S	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4707					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TGATCATTCTACATATATTGT	0.323													15	34					0	0	0	0	T	123274986	T	T	123274986	3	4	29	1	0	0	0	0	1	0	0	0	8247	391	14	5	14437	5	KIAA1109	4	123274986	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	446265	123274986	67879290	132	5666											
FAT4	79633	broad.mit.edu	37	chr4	126237812	126237812	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagccacgccctgtttgcCataaacagtagcaccggagc	12	6	10	13	2	0	0	0	0	0	0	0	2	0	1	4	1	5	3	4	1	4	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:126237812C>T	uc003ifj.3	+	1	246	c.246C>T	c.(244-246)GCC>GCT	p.A82A		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	82	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCCTGTTTGCCATAAACAGTA	0.622											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	57					0	0	0	0	T	126237812	T	T	126237812	2	4	29	1	0	0	0	0	0	0	0	1	5724	581	21	4		4	FAT4	4	126237812	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2962826	126237812	64916464	133	5667											
USP38	84640	broad.mit.edu	37	chr4	144119035	144119035	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcttgcagttctttctcaCatgctgcttagctttcagca	6	16	7	12	0	4	0	2	0	3	0	5	0	4	0	0	0	5	7	0	0	1	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:144119035C>A	uc003ijb.2	+	4	1542	c.1008C>A	c.(1006-1008)CAC>CAA	p.H336Q	USP38_uc003ija.3_Missense_Mutation_p.H336Q|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	336					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					TTCTTTCTCACATGCTGCTTA	0.373													21	58					4.87955e-14	5.79376e-14	1	0	A	144119035	A	A	144119035	3	1	29	1	0	0	0	0	1	0	0	0	17137	477	17	4	1022	4	USP38	4	144119035	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	17881223	144119035	47035241	134	5668											
LRBA	987	broad.mit.edu	37	chr4	151392833	151392833	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatatctctctgtgttgccAtcgctgggtcatattagaag	9	14	10	8	1	3	2	1	0	2	2	5	2	3	2	1	1	1	2	1	1	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:151392833A>G	uc010ipj.2	-	44	7117	c.6643T>C	c.(6643-6645)TGG>CGG	p.W2215R	LRBA_uc003ils.3_Missense_Mutation_p.W105R|LRBA_uc003ilt.3_Missense_Mutation_p.W863R|LRBA_uc003ilu.3_Missense_Mutation_p.W2204R	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2215	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding	p.W2215R(1)		ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CTGTGTTGCCATCGCTGGGTC	0.323													36	78					0	0	0	0	G	151392833	G	G	151392833	3	3	29	1	0	0	0	0	1	0	0	0	8981	217	8	5	2008	5	LRBA	4	151392833	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	7273798	151392833	39761443	135	5669											
LRBA	987	broad.mit.edu	37	chr4	151682970	151682970	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcgataaaagcaaggccTgcattcttctgaatagaatt	14	12	8	7	1	2	2	0	1	2	1	3	3	2	2	1	1	2	3	1	1	6	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:151682970T>G	uc010ipj.2	-	35	6084	c.5610A>C	c.(5608-5610)GCA>GCC	p.A1870A	LRBA_uc003ilt.3_Silent_p.A529A|LRBA_uc003ilu.3_Silent_p.A1870A	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1870						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					AAGCAAGGCCTGCATTCTTCT	0.264													28	41					0	0	0	0	G	151682970	G	G	151682970	2	3	29	1	0	0	0	0	0	0	0	1	8981	1567	55	5		5	LRBA	4	151682970	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	290137	151682970	39471306	136	5670											
RXFP1	59350	broad.mit.edu	37	chr4	159572918	159572918	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttcttttttaggtaccataaCctcttgggtagtgattttta	8	20	7	6	0	2	1	0	1	2	0	2	1	2	1	2	2	2	2	2	2	5	11			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:159572918C>A	uc003ipz.2	+	18	2067	c.1985C>A	c.(1984-1986)ACC>AAC	p.T662N	RXFP1_uc011cja.1_Missense_Mutation_p.T557N|RXFP1_uc010iqo.2_Missense_Mutation_p.T614N|RXFP1_uc011cjb.1_Missense_Mutation_p.T560N|RXFP1_uc010iqk.2_Missense_Mutation_p.T530N|RXFP1_uc011cjc.1_Missense_Mutation_p.T581N|RXFP1_uc011cjd.1_Missense_Mutation_p.T581N|RXFP1_uc010iql.2_Missense_Mutation_p.T506N|RXFP1_uc011cje.1_Missense_Mutation_p.T689N|RXFP1_uc010iqm.2_Missense_Mutation_p.T629N|RXFP1_uc011cjf.1_Missense_Mutation_p.T531N|RXFP1_uc010iqn.2_Missense_Mutation_p.T607N	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	662	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		GGTACCATAACCTCTTGGGTA	0.343													9	32					2.74318e-10	3.10445e-10	1	0	A	159572918	A	A	159572918	3	1	29	1	0	0	0	0	1	0	0	0	13824	507	18	4	2055	4	RXFP1	4	159572918	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	7889948	159572918	31581358	137	5671											
NPY1R	4886	broad.mit.edu	37	chr4	164247135	164247135	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acacgtatttgtctttgtacGcatcaagtgttacattttgg	9	17	8	7	2	2	0	1	0	1	0	2	0	2	0	0	1	2	4	0	1	4	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:164247135G>T	uc003iqm.1	-	2	838	c.572C>A	c.(571-573)GCG>GAG	p.A191E	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	191	Extracellular (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GTCTTTGTACGCATCAAGTGT	0.433													13	54					4.36969e-10	4.9014e-10	1	0	T	164247135	T	T	164247135	3	4	29	1	0	0	0	0	1	0	0	0	10662	1087	38	3	590	3	NPY1R	4	164247135	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4674217	164247135	26907141	138	5672											
TLL1	7092	broad.mit.edu	37	chr4	166986968	166986968	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgagaattgaattcaaatCtgacaatactgtatccaaga	17	12	6	6	0	2	4	1	3	1	2	3	5	3	4	1	0	1	1	1	0	8	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:166986968C>T	uc003irh.1	+	16	2788	c.2141C>T	c.(2140-2142)TCT>TTT	p.S714F	TLL1_uc011cjn.1_Missense_Mutation_p.S737F|TLL1_uc011cjo.1_Missense_Mutation_p.S538F	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	714	CUB 3.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GAATTCAAATCTGACAATACT	0.388													43	85					0	0	0	0	T	166986968	T	T	166986968	3	4	29	1	0	0	0	0	1	0	0	0	16011	913	32	2	2203	2	TLL1	4	166986968	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2739833	166986968	24167308	139	5673											
GLRA3	8001	broad.mit.edu	37	chr4	175649783	175649783	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaggtctaaagagtcgtcagGatattcactgtacgcgaggc	11	9	13	8	3	3	1	2	0	1	1	4	4	3	2	0	3	1	1	0	3	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:175649783G>C	uc003ity.1	-	4	837	c.334C>G	c.(334-336)CCT>GCT	p.P112A	GLRA3_uc003itz.1_Missense_Mutation_p.P112A	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	112	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GAGTCGTCAGGATATTCACTG	0.398													26	51					0	0	0	0	C	175649783	C	C	175649783	3	2	29	1	0	0	0	0	1	0	0	0	6493	1174	41	2	1088	2	GLRA3	4	175649783	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	8662815	175649783	15504493	140	5674											
ADAM29	11086	broad.mit.edu	37	chr4	175898234	175898234	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaatactgcaagtgagactTgctacaaagaattgaacacc	17	8	7	9	0	0	3	0	2	0	2	0	4	0	3	1	0	5	2	1	0	7	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:175898234T>A	uc003iuc.2	+	5	2228	c.1558T>A	c.(1558-1560)TGC>AGC	p.C520S	ADAM29_uc003iud.2_Missense_Mutation_p.C520S|ADAM29_uc010irr.2_Missense_Mutation_p.C520S|ADAM29_uc011cki.1_Missense_Mutation_p.C520S	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	520	Cys-rich.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AAGTGAGACTTGCTACAAAGA	0.433													21	53					0	0	0	0	A	175898234	A	A	175898234	3	1	29	1	0	0	0	0	1	0	0	0	247	1812	63	5	1560	5	ADAM29	4	175898234	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	248451	175898234	15256042	141	5675											
WDR17	116966	broad.mit.edu	37	chr4	177072972	177072972	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaaaaccagtctgaagctCaagaactaacaacagtcaag	18	8	6	9	0	3	2	2	1	1	1	3	2	3	2	1	0	5	1	1	0	8	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:177072972C>A	uc003iuj.2	+	18	2542	c.2386C>A	c.(2386-2388)CAA>AAA	p.Q796K	WDR17_uc003iuk.2_Missense_Mutation_p.Q772K|WDR17_uc003ium.3_Missense_Mutation_p.Q772K|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.Q15K	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	796										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GTCTGAAGCTCAAGAACTAAC	0.284													16	36					1.33834e-09	1.49129e-09	1	0	A	177072972	A	A	177072972	3	1	29	1	0	0	0	0	1	0	0	0	17345	827	29	2	2452	2	WDR17	4	177072972	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1174738	177072972	14081304	142	5676											
CDKN2AIP	55602	broad.mit.edu	37	chr4	184366134	184366134	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctagcacggatgaagctgccGacgccgagagcgggacccga	10	3	15	13	6	0	2	0	1	0	1	0	7	0	4	3	2	4	2	3	2	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr4:184366134G>A	uc003ivp.1	+	1	346	c.184G>A	c.(184-186)GAC>AAC	p.D62N	CDKN2AIP_uc003ivq.1_5'UTR	NM_017632	NP_060102	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	62					negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding				0		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		TGAAGCTGCCGACGCCGAGAG	0.667													23	39					0	0	0	0	A	184366134	A	A	184366134	3	1	29	1	0	0	0	0	1	0	0	0	3177	1058	37	1	186	1	CDKN2AIP	4	184366134	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	7293162	184366134	6788142	143	5677											
IRX4	50805	broad.mit.edu	37	chr5	1880913	1880913	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctggtgccaggcccccatgCgcagatcccgaaccatcctt	7	7	10	17	2	0	1	0	0	0	1	2	2	2	1	6	2	3	2	6	2	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:1880913C>G	uc003jcz.2	-	3	452	c.333G>C	c.(331-333)GCG>GCC	p.A111A	IRX4_uc011cmf.1_5'UTR	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	111					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		GGCCCCCATGCGCAGATCCCG	0.622													32	91					0	0	0	0	G	1880913	G	G	1880913	2	3	29	1	0	0	0	0	0	0	0	1	7885	755	27	3		3	IRX4	5	1880913	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08		1880913	179034347	144	5678											
IRX1	79192	broad.mit.edu	37	chr5	3599605	3599605	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacctggttcgccaacgcGcgccggcgcctcaagaagga	8	5	12	16	6	1	1	1	0	0	1	3	2	2	2	5	3	1	1	5	3	3	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:3599605G>C	uc003jde.2	+	2	595	c.543G>C	c.(541-543)GCG>GCC	p.A181A		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	181	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						TCGCCAACGCGCGCCGGCGCC	0.632													24	79					0	0	0	0	C	3599605	C	C	3599605	2	2	29	1	0	0	0	0	0	0	0	1	7882	1074	38	3		3	IRX1	5	3599605	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1718692	3599605	177315655	145	5679											
KIAA0947	23379	broad.mit.edu	37	chr5	5465077	5465077	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcccagggaacctccctcCagctgaagttgcaacaacaa	12	6	7	16	0	0	1	0	1	0	0	3	2	3	2	5	1	5	3	5	1	5	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:5465077C>T	uc003jdm.3	+	13	5852	c.5630C>T	c.(5629-5631)CCA>CTA	p.P1877L		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1877										ovary(1)|central_nervous_system(1)	2						AACCTCCCTCCAGCTGAAGTT	0.507													7	20					0	0	0	0	T	5465077	T	T	5465077	3	4	29	1	0	0	0	0	1	0	0	0	8241	594	21	4	5680	4	KIAA0947	5	5465077	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1865472	5465077	175450183	146	5680											
CDH12	1010	broad.mit.edu	37	chr5	21783484	21783484	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tactaactttactcgcaattAtggagaaattatactgcgca	14	13	6	8	2	0	1	0	0	0	1	1	2	0	1	0	1	5	2	0	1	8	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:21783484A>G	uc010iuc.2	-	8	1834	c.1376T>C	c.(1375-1377)ATA>ACA	p.I459T	CDH12_uc011cno.1_Missense_Mutation_p.I419T|CDH12_uc003jgk.2_Missense_Mutation_p.I459T	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	459	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						ACTCGCAATTATGGAGAAATT	0.383										HNSCC(59;0.17)			35	69					0	0	0	0	G	21783484	G	G	21783484	3	3	29	1	0	0	0	0	1	0	0	0	3113	449	16	5	1028	5	CDH12	5	21783484	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	16318407	21783484	159131776	147	5681											
C5orf22	55322	broad.mit.edu	37	chr5	31552888	31552888	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttggttctaggtcaagtcTggatgattactgtccttctg	6	17	11	7	0	4	1	1	1	3	0	5	2	5	2	1	3	1	2	1	3	3	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:31552888T>A	uc003jhj.3	+	9	1335	c.1208T>A	c.(1207-1209)CTG>CAG	p.L403Q	C5orf22_uc003jhk.3_Missense_Mutation_p.L138Q|C5orf22_uc010iuj.2_Missense_Mutation_p.L138Q	NM_018356	NP_060826	Q49AR2	CE022_HUMAN	hypothetical protein LOC55322	403										ovary(2)	2						AGGTCAAGTCTGGATGATTAC	0.383													23	39					0	0	0	0	A	31552888	A	A	31552888	3	1	29	1	0	0	0	0	1	0	0	0	2295	1580	55	5	1242	5	C5orf22	5	31552888	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	9769404	31552888	149362372	148	5682											
C1QTNF3	114899	broad.mit.edu	37	chr5	34035786	34035786	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcccggtggcccagggggGccttggtagcctcgaaagct	5	6	18	12	2	0	0	0	0	0	0	1	1	0	0	4	7	2	2	4	7	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:34035786G>T	uc003jin.2	-	2	249	c.162C>A	c.(160-162)GGC>GGA	p.G54G	C1QTNF3_uc003jio.2_Silent_p.G127G	NM_030945	NP_112207	Q9BXJ4	C1QT3_HUMAN	C1q and tumor necrosis factor related protein 3	54	Collagen-like.					collagen					0	all_lung(31;0.0207)					GCCCAGGGGGGCCTTGGTAGC	0.522													10	36					2.27111e-07	2.45512e-07	1	0	T	34035786	T	T	34035786	2	4	29	1	0	0	0	0	0	0	0	1	1973	1190	42	4		4	C1QTNF3	5	34035786	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2482898	34035786	146879474	149	5683											
EGFLAM	133584	broad.mit.edu	37	chr5	38448428	38448428	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atagaagccattgagatcccGcagtttatcggccgcagtta	11	10	10	10	3	0	2	0	1	0	2	2	3	1	2	3	1	1	4	3	1	4	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:38448428G>A	uc003jlc.1	+	19	2838	c.2514G>A	c.(2512-2514)CCG>CCA	p.P838P	EGFLAM_uc003jlb.1_Silent_p.P830P|EGFLAM_uc003jle.1_Silent_p.P596P|EGFLAM_uc003jlf.1_Silent_p.P196P|EGFLAM_uc003jlg.1_5'UTR	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	838	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TTGAGATCCCGCAGTTTATCG	0.473													48	134					0	0	0	0	A	38448428	A	A	38448428	2	1	29	1	0	0	0	0	0	0	0	1	4988	1074	38	1		1	EGFLAM	5	38448428	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4412642	38448428	142466832	150	5684											
OXCT1	5019	broad.mit.edu	37	chr5	41853618	41853618	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaccatgcgttttatctgcTtggaccgaagcaaaagcccc	11	9	9	12	2	1	1	0	0	1	1	1	3	1	2	4	1	4	3	4	1	4	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:41853618T>A	uc003jmn.2	-	4	648	c.317A>T	c.(316-318)AAG>ATG	p.K106M		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	106					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	TTTTATCTGCTTGGACCGAAG	0.418													13	41					0	0	0	0	A	41853618	A	A	41853618	3	1	29	1	0	0	0	0	1	0	0	0	11383	1609	56	5	1301	5	OXCT1	5	41853618	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	3405190	41853618	139061642	151	5685											
IL31RA	133396	broad.mit.edu	37	chr5	55192206	55192206	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcctggaactgtggagagtCctgaaaccagctgaggcgga	10	6	16	9	1	0	3	0	2	0	1	1	6	1	5	3	5	3	1	3	5	2	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:55192206C>T	uc003jql.2	+	7	866	c.801C>T	c.(799-801)GTC>GTT	p.V267V	IL31RA_uc003jqk.2_Silent_p.V267V|IL31RA_uc011cqj.1_Silent_p.V125V|IL31RA_uc003jqm.2_Silent_p.V235V|IL31RA_uc003jqn.2_Silent_p.V267V|IL31RA_uc010iwa.1_Silent_p.V235V|IL31RA_uc003jqo.2_Silent_p.V125V	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	235	Extracellular (Potential).|Fibronectin type-III 3.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				TGTGGAGAGTCCTGAAACCAG	0.443													41	62					0	0	0	0	T	55192206	T	T	55192206	2	4	29	1	0	0	0	0	0	0	0	1	7730	842	30	2		2	IL31RA	5	55192206	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	13338588	55192206	125723054	152	5686											
GAPT	202309	broad.mit.edu	37	chr5	57790833	57790833	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atacattcttccagattcatAttagcttttcaaaatattga	14	17	3	7	0	3	2	2	1	1	1	4	2	4	2	1	0	2	1	1	0	6	10			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:57790833A>T	uc003jro.1	+	3	864	c.470A>T	c.(469-471)TAT>TTT	p.Y157F		NM_152687	NP_689900	Q8N292	GAPT_HUMAN	GRB2-binding adaptor protein, transmembrane	157					B cell activation	integral to membrane|plasma membrane					0						CCAGATTCATATTAGCTTTTC	0.224													8	19					0	0	0	0	T	57790833	T	T	57790833	3	4	29	1	0	0	0	0	1	0	0	0	6273	449	16	5	472	5	GAPT	5	57790833	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	2598627	57790833	123124427	153	5687											
MAST4	375449	broad.mit.edu	37	chr5	66459668	66459668	+	Frame_Shift_Del	DEL	C	-	-																															acaggaatcccaccagaaatCccatggacccgggagtgatt																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:66459668delC	uc003jut.1	+	28	4162	c.4094delC	c.(4093-4095)TCCfs	p.S1365fs	MAST4_uc003juw.2_Frame_Shift_Del_p.S1293fs|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1557						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CACCAGAAATCCCATGGACCC	0.507													---	---	---								-	66459668	-	-	66459668	7	5	29	1	0	1	0	1	0	0	0	0	9380	855	30	0	4905	0	MAST4	5	66459668	Frame_Shift_Del	DEL	C	TCGA-BB-7862-01A-21D-2229-08	8668835	66459668	114455592	154	5688											
FAM169A	26049	broad.mit.edu	37	chr5	74109689	74109689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atacatgagagaagacagtgGataccgcaagccaagcgcat	16	5	11	9	2	0	3	0	1	0	2	0	5	0	4	2	1	4	2	2	1	5	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:74109689G>A	uc003kdm.2	-	6	689	c.646C>T	c.(646-648)CCA>TCA	p.P216S	FAM169A_uc010izm.2_Intron|FAM169A_uc003kdl.2_Missense_Mutation_p.P34S	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	216											0						GAAGACAGTGGATACCGCAAG	0.363													36	50					0	0	0	0	A	74109689	A	A	74109689	3	1	29	1	0	0	0	0	1	0	0	0	5515	1174	41	2	1398	2	FAM169A	5	74109689	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	7650021	74109689	106805571	155	5689											
CMYA5	202333	broad.mit.edu	37	chr5	79028981	79028981	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttttgtcagaagtagaaGccaaagaagttaaagctggg	14	10	12	5	0	1	3	1	0	0	3	1	3	1	3	1	1	2	4	1	1	7	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:79028981G>A	uc003kgc.2	+	2	4465	c.4393G>A	c.(4393-4395)GCC>ACC	p.A1465T		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1465						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGAAGTAGAAGCCAAAGAAGT	0.378													21	37					0	0	0	0	A	79028981	A	A	79028981	3	1	29	1	0	0	0	0	1	0	0	0	3605	971	34	4	4399	4	CMYA5	5	79028981	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4919292	79028981	101886279	156	5690											
DHFR	1719	broad.mit.edu	37	chr5	79924954	79924954	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtacttaatgcctttctcCtcctggacatcagagagaac	10	13	7	11	0	2	2	1	0	1	2	4	4	3	3	3	1	3	1	3	1	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:79924954C>A	uc003kgy.1	-	6	1008	c.516G>T	c.(514-516)GAG>GAT	p.E172D	DHFR_uc011ctl.1_3'UTR|DHFR_uc011ctm.1_Missense_Mutation_p.E120D|DHFR_uc010jap.1_RNA|DHFR_uc003kgx.1_Missense_Mutation_p.E321D	NM_000791	NP_000782	P00374	DYR_HUMAN	dihydrofolate reductase	172	DHFR.				folic acid metabolic process|glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to methotrexate|tetrahydrofolate metabolic process	cytosol	dihydrofolate reductase activity|drug binding|folate reductase activity|NADP binding				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.69e-46)|Epithelial(54;7.49e-41)|all cancers(79;1.54e-35)	Dapsone(DB00250)|Dimethyl sulfoxide(DB01093)|Lamotrigine(DB00555)|Methotrexate(DB00563)|NADH(DB00157)|Pemetrexed(DB00642)|Proguanil(DB01131)|Pyrimethamine(DB00205)|Trimethoprim(DB00440)|Trimetrexate(DB01157)	TGCCTTTCTCCTCCTGGACAT	0.328													9	20					5.50884e-06	5.80661e-06	1	0	A	79924954	A	A	79924954	3	1	29	1	0	0	0	0	1	0	0	0	4503	680	24	4	51	4	DHFR	5	79924954	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	895973	79924954	100990306	157	5691											
GPR98	84059	broad.mit.edu	37	chr5	89923209	89923209	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcataattccagtagttcGtggaaaggacaacaatggaa	16	9	9	7	1	1	0	1	0	0	0	3	3	2	3	1	3	1	2	1	3	6	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:89923209G>T	uc003kju.2	+	7	950	c.854G>T	c.(853-855)CGT>CTT	p.R285L	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	285	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCAGTAGTTCGTGGAAAGGAC	0.393													50	119					8.24881e-48	1.15849e-47	1	0	T	89923209	T	T	89923209	3	4	29	1	0	0	0	0	1	0	0	0	6760	1145	40	3	880	3	GPR98	5	89923209	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	9998255	89923209	90992051	158	5692											
PCSK1	5122	broad.mit.edu	37	chr5	95743993	95743993	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccgaggtgcctgtgtgcGtctccgtgcagtcattgtgc	4	11	15	11	3	2	0	1	0	1	0	3	1	2	0	3	2	4	1	3	2	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:95743993G>A	uc003kls.1	-	9	1336	c.1130C>T	c.(1129-1131)ACG>ATG	p.T377M	PCSK1_uc010jbi.1_Missense_Mutation_p.T67M	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	377	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCCTGTGTGCGTCTCCGTGCA	0.577													18	31					0	0	0	0	A	95743993	A	A	95743993	3	1	29	1	0	0	0	0	1	0	0	0	11654	1145	40	1	1155	1	PCSK1	5	95743993	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	5820784	95743993	85171267	159	5693											
ST8SIA4	7903	broad.mit.edu	37	chr5	100147576	100147576	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctttacacactttcctgttGtcagttttagagctcctcta	7	17	6	11	0	2	1	1	0	1	1	4	1	4	1	2	0	2	4	2	0	3	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:100147576G>T	uc003knk.2	-	5	1383	c.1055C>A	c.(1054-1056)ACA>AAA	p.T352K		NM_005668	NP_005659	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide	352	Lumenal (Potential).				axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			large_intestine(1)|central_nervous_system(1)	2		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		CTTTCCTGTTGTCAGTTTTAG	0.338													13	34					9.31168e-06	9.77437e-06	1	0	T	100147576	T	T	100147576	3	4	29	1	0	0	0	0	1	0	0	0	15300	1377	48	4	28	4	ST8SIA4	5	100147576	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4403583	100147576	80767684	160	5694											
SLCO6A1	133482	broad.mit.edu	37	chr5	101834371	101834371	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttcggaaaccgccgaaccTtatcaaggcctctggaagta	11	10	9	11	3	2	0	1	0	1	0	3	3	2	2	4	3	2	1	4	3	6	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:101834371T>A	uc003knn.2	-	1	350	c.178A>T	c.(178-180)AGG>TGG	p.R60W	SLCO6A1_uc003kno.2_Missense_Mutation_p.R60W|SLCO6A1_uc003knp.2_Missense_Mutation_p.R60W|SLCO6A1_uc003knq.2_Missense_Mutation_p.R60W	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	60	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity	p.R60S(1)		ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CCGCCGAACCTTATCAAGGCC	0.552													74	183					0	0	0	0	A	101834371	A	A	101834371	3	1	29	1	0	0	0	0	1	0	0	0	14796	1608	56	5	2033	5	SLCO6A1	5	101834371	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	1686795	101834371	79080889	161	5695											
FAM170A	340069	broad.mit.edu	37	chr5	118970235	118970235	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacgtctttcatctcaccatGgctcagctgacaggcaacat	10	10	7	14	1	4	1	3	1	2	0	5	1	4	1	1	2	2	3	1	2	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:118970235G>T	uc003ksm.2	+	3	1002	c.792G>T	c.(790-792)ATG>ATT	p.M264I	FAM170A_uc003ksl.2_Intron|FAM170A_uc003ksn.2_Missense_Mutation_p.M264I|FAM170A_uc003kso.2_Missense_Mutation_p.M217I	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	264						intracellular	zinc ion binding			skin(1)	1						ATCTCACCATGGCTCAGCTGA	0.398													78	156					8.16569e-41	1.13115e-40	1	0	T	118970235	T	T	118970235	3	4	29	1	0	0	0	0	1	0	0	0	5517	1348	47	4	802	4	FAM170A	5	118970235	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	17135864	118970235	61945025	162	5696											
FTMT	94033	broad.mit.edu	37	chr5	121187935	121187935	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgagctctatgcgtcctacGtgtacttgtccatggcctat	6	14	9	12	3	1	0	0	0	1	0	4	1	3	0	3	1	4	2	3	1	4	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:121187935G>T	uc003kss.2	+	1	286	c.277G>T	c.(277-279)GTG>TTG	p.V93L		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	93	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		TGCGTCCTACGTGTACTTGTC	0.622													21	49					1.10513e-12	1.28216e-12	1	0	T	121187935	T	T	121187935	3	4	29	1	0	0	0	0	1	0	0	0	6119	1145	40	3	279	3	FTMT	5	121187935	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2217700	121187935	59727325	163	5697											
ACSL6	23305	broad.mit.edu	37	chr5	131302194	131302194	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgtctggatctttcaagtagCctttgaacacatttggtcct	8	16	8	9	0	3	1	1	1	2	0	4	2	4	2	2	2	2	1	2	2	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:131302194C>T	uc010jdo.1	-	17	1636	c.1553G>A	c.(1552-1554)GGC>GAC	p.G518D	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.G543D|ACSL6_uc003kvy.1_Missense_Mutation_p.G543D|ACSL6_uc003kwb.2_Missense_Mutation_p.G508D|ACSL6_uc003kvz.1_Missense_Mutation_p.G443D|ACSL6_uc003kwa.1_Missense_Mutation_p.G529D|ACSL6_uc003kvw.1_Missense_Mutation_p.G164D|ACSL6_uc010jdn.1_Missense_Mutation_p.G533D	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	518	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTTCAAGTAGCCTTTGAACAC	0.502													36	92					0	0	0	0	T	131302194	T	T	131302194	3	4	29	1	0	0	0	0	1	0	0	0	181	739	26	4	560	4	ACSL6	5	131302194	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	10114259	131302194	49613066	164	5698											
SEC24A	10802	broad.mit.edu	37	chr5	134032863	134032863	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctataagaaattagccttGgactgttctggtcagcaagt	11	14	9	7	0	3	1	1	0	2	1	3	2	3	2	1	2	2	2	1	2	5	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:134032863G>T	uc003kzs.2	+	14	2322	c.2034G>T	c.(2032-2034)TTG>TTT	p.L678F	SEC24A_uc011cxu.1_Missense_Mutation_p.L442F	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	678					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AATTAGCCTTGGACTGTTCTG	0.323													56	83					4.10029e-35	5.6185e-35	1	0	T	134032863	T	T	134032863	3	4	29	1	0	0	0	0	1	0	0	0	14059	1339	47	4	2088	4	SEC24A	5	134032863	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2730669	134032863	46882397	165	5699											
KDM3B	51780	broad.mit.edu	37	chr5	137727661	137727661	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcggctttctgtcctccccGgcagatttttcacaggagaa	7	11	11	12	2	2	2	1	0	1	2	4	3	4	2	3	4	0	2	3	4	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:137727661G>A	uc003lcy.1	+	8	2540	c.2340G>A	c.(2338-2340)CCG>CCA	p.P780P	KDM3B_uc010jew.1_Silent_p.P436P|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	780					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						TGTCCTCCCCGGCAGATTTTT	0.532													157	306					0	0	0	0	A	137727661	A	A	137727661	2	1	29	1	0	0	0	0	0	0	0	1	8166	1103	39	1		1	KDM3B	5	137727661	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	3694798	137727661	43187599	166	5700											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139909127	139909127	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cataaacccagcaaataagtCtttgccacctacatttggcc	13	10	5	13	0	1	0	0	0	1	0	1	0	1	0	4	1	4	1	4	1	5	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:139909127C>G	uc003lfs.1	+	29	6720	c.6596C>G	c.(6595-6597)TCT>TGT	p.S2199C	ANKHD1_uc003lfr.2_Missense_Mutation_p.S2199C|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.S938C|ANKHD1_uc003lfw.2_Missense_Mutation_p.S837C|ANKHD1_uc010jfl.2_Missense_Mutation_p.S634C|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.S336C	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2199						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAATAAGTCTTTGCCACCT	0.478													58	83					0	0	0	0	G	139909127	G	G	139909127	3	3	29	1	0	0	0	0	1	0	0	0	629	913	32	2	6710	2	ANKHD1-EIF4EBP3	5	139909127	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2181466	139909127	41006133	167	5701											
ZMAT2	153527	broad.mit.edu	37	chr5	140080472	140080472	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaactcgccgagaagaggctCacggaagagagagaaaagaa	19	2	13	7	3	1	5	1	0	0	5	2	9	1	6	1	2	1	1	1	2	6	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:140080472C>G	uc003lgy.1	+	2	101	c.87C>G	c.(85-87)CTC>CTG	p.L29L		NM_144723	NP_653324	Q96NC0	ZMAT2_HUMAN	zinc finger, matrin type 2	29						nucleus	DNA binding|zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAGAGGCTCACGGAAGAGA	0.498													10	23					0	0	0	0	G	140080472	G	G	140080472	2	3	29	1	0	0	0	0	0	0	0	1	17759	813	29	2		2	ZMAT2	5	140080472	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	171345	140080472	40834788	168	5702											
PCDHA8	56140	broad.mit.edu	37	chr5	140222189	140222189	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgagttggtggtaaccgcgcGggacgggggctcgccttcgc	4	8	18	11	6	0	1	0	1	0	0	2	2	0	2	2	5	1	3	2	5	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:140222189G>A	uc003lhs.2	+	1	1283	c.1283G>A	c.(1282-1284)CGG>CAG	p.R428Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.R428Q	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	428	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTAACCGCGCGGGACGGGGGC	0.632													100	135					0	0	0	0	A	140222189	A	A	140222189	3	1	29	1	0	0	0	0	1	0	0	0	11584	1116	39	1	1285	1	PCDHA8	5	140222189	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	141717	140222189	40693071	169	5703											
PCDHB4	56131	broad.mit.edu	37	chr5	140502659	140502660	+	Frame_Shift_Del	DEL	CT	-	-																															ctccatcccagaaaatgctcCtgagacggtagtctctatct																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:140502659_140502660delCT	uc003lip.1	+	1	1079_1080	c.1079_1080delCT	c.(1078-1080)CCTfs	p.P360fs		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	360	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAAATGCTCCTGAGACGGTAG	0.421													---	---	---								-	140502660	-	-	140502659	7	5	29	1	0	1	0	1	0	0	0	0	11598	681	24	0	1081	0	PCDHB4	5	140502659	Frame_Shift_Del	DEL	CT	TCGA-BB-7862-01A-21D-2229-08	280470	140502659	40412601	170	5704											
PCDHB16	57717	broad.mit.edu	37	chr5	140563029	140563029	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggaggtaaatcctatgacaGgggaagttcgactgagaaag	14	8	14	5	1	0	2	0	2	0	1	2	6	1	4	1	4	0	2	1	4	5	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:140563029G>T	uc003liv.2	+	1	2050	c.895G>T	c.(895-897)GGG>TGG	p.G299W	PCDHB16_uc010jfw.1_Intron	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	299	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTATGACAGGGGAAGTTCG	0.453													33	56					7.83172e-31	1.04767e-30	1	0	T	140563029	T	T	140563029	3	4	29	1	0	0	0	0	1	0	0	0	11595	1000	35	4	897	4	PCDHB16	5	140563029	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	60370	140563029	40352231	171	5705											
PCDHGB1	56104	broad.mit.edu	37	chr5	140730296	140730296	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctggattctgctcaagatGcagatgtggaaggcaattca	11	11	11	8	0	4	2	2	0	2	2	4	4	4	4	0	3	2	3	0	3	3	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:140730296G>A	uc003ljo.1	+	1	469	c.469G>A	c.(469-471)GCA>ACA	p.A157T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.A157T	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	157	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTCAAGATGCAGATGTGGA	0.423													105	181					0	0	0	0	A	140730296	A	A	140730296	3	1	29	1	0	0	0	0	1	0	0	0	11616	1319	46	4	471	4	PCDHGB1	5	140730296	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	167267	140730296	40184964	172	5706											
PCDHGB1	56104	broad.mit.edu	37	chr5	140731764	140731764	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggtcgctgtgcgtgatggagGacagccgccactctccgcca	6	7	14	14	4	1	1	0	1	1	0	3	3	1	3	4	3	2	1	4	3	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:140731764G>A	uc003ljo.1	+	1	1937	c.1937G>A	c.(1936-1938)GGA>GAA	p.G646E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.G646E	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	646	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGATGGAGGACAGCCGCCA	0.682													29	44					0	0	0	0	A	140731764	A	A	140731764	3	1	29	1	0	0	0	0	1	0	0	0	11616	1174	41	2	1939	2	PCDHGB1	5	140731764	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1468	140731764	40183496	173	5707											
PCDHGA6	56109	broad.mit.edu	37	chr5	140754340	140754340	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcgtcgcccaaattctggtAacagttctagatgtgaatga	12	11	10	8	2	2	3	0	2	2	1	3	3	2	3	1	1	2	2	1	1	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:140754340A>G	uc003ljy.1	+	1	690	c.690A>G	c.(688-690)GTA>GTG	p.V230V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.V230V	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	230	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAATTCTGGTAACAGTTCTAG	0.542													9	26					0	0	0	0	G	140754340	G	G	140754340	2	3	29	1	0	0	0	0	0	0	0	1	11612	349	13	5		5	PCDHGA6	5	140754340	Silent	SNP	A	TCGA-BB-7862-01A-21D-2229-08	22576	140754340	40160920	174	5708											
PCDHGB6	56100	broad.mit.edu	37	chr5	140789910	140789910	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattctggccattgccttgcGcctgcgacgctctctcagcc	4	11	10	16	3	3	0	1	0	2	0	4	2	3	0	4	1	4	1	4	1	0	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:140789910G>A	uc003lkj.1	+	1	2141	c.2141G>A	c.(2140-2142)CGC>CAC	p.R714H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.R714H|PCDHGA10_uc011day.1_5'Flank|PCDHGA10_uc003lkl.1_5'Flank	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	714	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGCCTTGCGCCTGCGACGC	0.577													64	101					0	0	0	0	A	140789910	A	A	140789910	3	1	29	1	0	0	0	0	1	0	0	0	11621	1087	38	1	2143	1	PCDHGB6	5	140789910	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	35570	140789910	40125350	175	5709											
RBM27	54439	broad.mit.edu	37	chr5	145610481	145610481	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcgatgcagagattatgatgGtaaaaatcaccaccttttct	13	12	8	8	1	2	2	1	1	1	1	2	4	2	2	2	1	1	2	2	1	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:145610481G>A	uc003lnz.3	+	6	1016	c.850_splice	c.e6+1	p.E284_splice	RBM27_uc003lny.2_Splice_Site_p.E284_splice	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27						mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GATTATGATGGTAAAAATCAC	0.348													47	33					0	0	0	0	A	145610481	A	A	145610481	5	1	29	1	0	0	0	0	0	0	1	0	13192	1275	44	4	873	4	RBM27	5	145610481	Splice_Site	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4820571	145610481	35304779	176	5710											
ANXA6	309	broad.mit.edu	37	chr5	150503912	150503912	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttgaagtcattggctgggCgcacagttcccttcagctgt	6	12	13	10	1	2	1	2	1	0	0	3	1	3	1	1	3	1	5	1	3	1	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:150503912C>T	uc003ltl.1	-	15	1225	c.1073G>A	c.(1072-1074)CGC>CAC	p.R358H	ANXA6_uc011dcp.1_Missense_Mutation_p.R326H|ANXA6_uc003ltm.1_Missense_Mutation_p.R358H|ANXA6_uc003ltn.1_Missense_Mutation_p.R151H|ANXA6_uc003lto.1_Intron	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	358						melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding				0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTGGCTGGGCGCACAGTTCC	0.597													8	5					0	0	0	0	T	150503912	T	T	150503912	3	4	29	1	0	0	0	0	1	0	0	0	722	768	27	1	996	1	ANXA6	5	150503912	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	4893431	150503912	30411348	177	5711											
CYFIP2	26999	broad.mit.edu	37	chr5	156723752	156723752	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtgctggagccggaggtCaccaagctcatgaagttcat	10	8	14	9	1	3	1	3	1	0	0	3	4	3	3	2	4	3	3	2	4	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:156723752C>A	uc003lwq.2	+	7	495	c.357C>A	c.(355-357)GTC>GTA	p.V119V	CYFIP2_uc011ddn.1_Silent_p.V93V|CYFIP2_uc011ddo.1_Intron|CYFIP2_uc003lwr.2_Silent_p.V119V|CYFIP2_uc003lws.2_Silent_p.V119V|CYFIP2_uc003lwt.2_5'UTR|CYFIP2_uc011ddp.1_5'UTR|CYFIP2_uc003lwp.2_5'UTR	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	119					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGCCGGAGGTCACCAAGCTCA	0.517													59	47					1.84395e-34	2.5199e-34	1	0	A	156723752	A	A	156723752	2	1	29	1	0	0	0	0	0	0	0	1	4155	813	29	2		2	CYFIP2	5	156723752	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	6219840	156723752	24191508	178	5712											
IL12B	3593	broad.mit.edu	37	chr5	158749420	158749420	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accctctgctgcttttgacaCtgaatgtcaaatcagtactg	10	13	7	11	0	3	2	2	2	1	0	3	2	3	2	1	0	3	3	1	0	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:158749420C>T	uc003lxr.1	-	4	506	c.464G>A	c.(463-465)AGT>AAT	p.S155N		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	155					cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTTTTGACACTGAATGTCAA	0.418													31	22					0	0	0	0	T	158749420	T	T	158749420	3	4	29	1	0	0	0	0	1	0	0	0	7664	565	20	4	538	4	IL12B	5	158749420	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2025668	158749420	22165840	179	5713											
C1QTNF2	114898	broad.mit.edu	37	chr5	159781811	159781811	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccggtcgccgtcgtgtcCatcttggccgtctttgccag	2	11	11	17	5	2	0	0	0	2	0	5	0	3	0	6	2	1	0	6	2	0	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr5:159781811C>A	uc003lyd.2	-	2	347	c.343G>T	c.(343-345)GGA>TGA	p.G115*		NM_031908	NP_114114	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	70	Collagen-like.					collagen				skin(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCGTCGTGTCCATCTTGGCCG	0.677													14	20					5.03518e-11	5.76261e-11	1	0	A	159781811	A	A	159781811	4	1	29	1	0	0	0	0	0	1	0	0	1972	603	21	4	657	4	C1QTNF2	5	159781811	Nonsense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1032391	159781811	21133449	180	5714											
SNRNP48	154007	broad.mit.edu	37	chr6	7609064	7609064	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcttttatttcagggatggGgaaagacaccatagtcataa	13	12	9	7	0	3	1	2	0	1	1	3	3	3	3	1	3	0	0	1	3	4	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:7609064G>A	uc003mxr.2	+	9	1037	c.978G>A	c.(976-978)GGG>GGA	p.G326G	SNRNP48_uc003mxs.2_RNA	NM_152551	NP_689764	Q6IEG0	SNR48_HUMAN	U11/U12 snRNP 48K	326	Arg-rich.				mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0						TCAGGGATGGGGAAAGACACC	0.279													4	4					0	0	0	0	A	7609064	A	A	7609064	2	1	29	1	0	0	0	0	0	0	0	1	14921	1219	43	4		4	SNRNP48	6	7609064	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08		7609064	163506003	181	5715											
CD83	9308	broad.mit.edu	37	chr6	14133945	14133945	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cggagattgtcctgctgctgGctctggttattttctactta	5	17	10	9	1	2	1	0	0	2	1	3	2	3	1	1	3	3	4	1	3	3	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:14133945G>T	uc003nbi.2	+	4	626	c.448G>T	c.(448-450)GCT>TCT	p.A150S	CD83_uc003nbh.2_Missense_Mutation_p.A150S	NM_004233	NP_004224	Q01151	CD83_HUMAN	CD83 antigen isoform a	150	Helical; (Potential).				defense response|humoral immune response|signal transduction	integral to plasma membrane					0	Breast(50;0.00245)|Ovarian(93;0.137)	all_hematologic(90;0.117)				CCTGCTGCTGGCTCTGGTTAT	0.378													25	14					1.62565e-12	1.88174e-12	1	0	T	14133945	T	T	14133945	3	4	29	1	0	0	0	0	1	0	0	0	3056	1203	42	4	462	4	CD83	6	14133945	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	6524881	14133945	156981122	182	5716											
TRIM26	7726	broad.mit.edu	37	chr6	30166632	30166632	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggctgcctgcccttgtcCaccttcagccgctcaatgtt	4	11	8	18	2	2	0	2	0	0	0	3	0	3	0	6	1	3	3	6	1	1	3	rs143331737	byFrequency	TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:30166632C>T	uc003npr.2	-	3	458	c.249G>A	c.(247-249)GTG>GTA	p.V83V	TRIM26_uc003nps.2_Silent_p.V83V|TRIM26_uc010jry.2_5'UTR|TRIM26_uc003npt.2_Silent_p.V83V|TRIM26_uc003npu.1_Silent_p.V83V	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	83							DNA binding|zinc ion binding			ovary(2)|lung(1)	3						TGCCCTTGTCCACCTTCAGCC	0.602													18	71					0	0	0	0	T	30166632	T	T	30166632	2	4	29	1	0	0	0	0	0	0	0	1	16567	581	21	4		4	TRIM26	6	30166632	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	16032687	30166632	140948435	183	5717											
DDR1	780	broad.mit.edu	37	chr6	30861116	30861116	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaccgccatcctcatcggCtgcctggtggccatcatcct	5	9	9	18	3	2	0	2	0	0	0	5	1	4	0	7	3	1	1	7	3	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:30861116C>G	uc003nrr.2	+	11	1522	c.1263C>G	c.(1261-1263)GGC>GGG	p.G421G	DDR1_uc010jse.2_Silent_p.G421G|DDR1_uc003nrq.2_Silent_p.G421G|DDR1_uc003nrs.2_Silent_p.G421G|DDR1_uc003nrt.2_Silent_p.G421G|DDR1_uc011dms.1_Silent_p.G439G|DDR1_uc003nru.2_Silent_p.G421G|DDR1_uc003nrv.2_Silent_p.G421G|DDR1_uc003nrw.1_Silent_p.G220G|DDR1_uc003nry.1_RNA|DDR1_uc003nrx.1_RNA	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	421	Helical; (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	TCCTCATCGGCTGCCTGGTGG	0.682													12	14					0	0	0	0	G	30861116	G	G	30861116	2	3	29	1	0	0	0	0	0	0	0	1	4353	784	28	4		4	DDR1	6	30861116	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	694484	30861116	140253951	184	5718											
DNAH8	1769	broad.mit.edu	37	chr6	38863890	38863890	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatattggctctgatgcagcGtcgtgtattcttcctgaacc	8	14	9	10	2	2	2	0	2	2	0	4	2	3	2	2	1	3	3	2	1	4	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:38863890G>A	uc003ooe.1	+	58	8778	c.8178G>A	c.(8176-8178)GCG>GCA	p.A2726A		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CTGATGCAGCGTCGTGTATTC	0.403													46	27					0	0	0	0	A	38863890	A	A	38863890	2	1	29	1	0	0	0	0	0	0	0	1	4629	1132	40	1		1	DNAH8	6	38863890	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	8002774	38863890	132251177	185	5719											
TFAP2D	83741	broad.mit.edu	37	chr6	50696657	50696657	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctacttccaaatacaaggtGaccattgctgaggtaaagag	14	10	9	8	0	1	3	0	2	1	1	2	3	2	3	2	2	3	2	2	2	6	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:50696657G>A	uc003paf.2	+	4	1199	c.687G>A	c.(685-687)GTG>GTA	p.V229V	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	229							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					AATACAAGGTGACCATTGCTG	0.493													30	33					0	0	0	0	A	50696657	A	A	50696657	2	1	29	1	0	0	0	0	0	0	0	1	15856	1277	45	2		2	TFAP2D	6	50696657	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	11832767	50696657	120418410	186	5720											
TFAP2B	7021	broad.mit.edu	37	chr6	50803977	50803977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctcaatgcatctctcctcGgcggagtcctcagaaggtaa	9	9	10	13	2	3	1	2	0	1	1	7	2	5	2	3	3	1	2	3	3	3	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:50803977G>A	uc003pag.2	+	4	971	c.805G>A	c.(805-807)GGC>AGC	p.G269S		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	269					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					ATCTCTCCTCGGCGGAGTCCT	0.418													9	6					0	0	0	0	A	50803977	A	A	50803977	3	1	29	1	0	0	0	0	1	0	0	0	15854	1116	39	1	819	1	TFAP2B	6	50803977	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	107320	50803977	120311090	187	5721											
PKHD1	5314	broad.mit.edu	37	chr6	51893046	51893046	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacctccaggccccaagcCgactgtgtgtgaaccggagc	8	5	12	16	2	0	1	0	1	0	0	1	3	1	2	7	2	3	0	7	2	2	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:51893046C>G	uc003pah.1	-	30	3744	c.3468G>C	c.(3466-3468)TCG>TCC	p.S1156S	PKHD1_uc003pai.2_Silent_p.S1156S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1156	Extracellular (Potential).|IPT/TIG 6; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGCCCCAAGCCGACTGTGTGT	0.572													95	76					0	0	0	0	G	51893046	G	G	51893046	2	3	29	1	0	0	0	0	0	0	0	1	12026	639	23	3		3	PKHD1	6	51893046	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1089069	51893046	119222021	188	5722											
LCA5	167691	broad.mit.edu	37	chr6	80202314	80202314	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttatttggagaggacttTggcagacgattagaatatat	12	15	10	4	1	1	3	0	0	1	3	1	6	1	4	0	3	0	1	0	3	5	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:80202314T>G	uc003pix.2	-	5	1344	c.909A>C	c.(907-909)CCA>CCC	p.P303P	LCA5_uc003piy.2_Silent_p.P303P|LCA5_uc011dyq.1_RNA	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	303					protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		GAGAGGACTTTGGCAGACGAT	0.299													7	5					0	0	0	0	G	80202314	G	G	80202314	2	3	29	1	0	0	0	0	0	0	0	1	8696	1799	63	5		5	LCA5	6	80202314	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	28309268	80202314	90912753	189	5723											
SYNCRIP	10492	broad.mit.edu	37	chr6	86324617	86324617	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgattattggtctggcgccGcttggaatctggctggttgt	4	15	14	8	2	2	1	0	1	2	0	2	2	2	2	1	5	0	3	1	5	2	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:86324617G>A	uc003pla.2	-	11	2270	c.1729C>T	c.(1729-1731)CGG>TGG	p.R577W	SYNCRIP_uc003pku.2_Intron|SYNCRIP_uc003pkw.2_Intron|SYNCRIP_uc003pky.2_Intron|SYNCRIP_uc003pkv.2_Intron|SYNCRIP_uc003pkx.2_Intron|SYNCRIP_uc003pkz.2_Missense_Mutation_p.R542W	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	577	Bipartite nuclear localization signal (Potential).				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		GTCTGGCGCCGCTTGGAATCT	0.542													68	191					0	0	0	0	A	86324617	A	A	86324617	3	1	29	1	0	0	0	0	1	0	0	0	15510	1086	38	1	192	1	SYNCRIP	6	86324617	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	6122303	86324617	84790450	190	5724											
MCHR2	84539	broad.mit.edu	37	chr6	100390887	100390887	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaacaccgtctttaaatttGatgaccttcgagtagaccca	12	12	6	11	2	2	3	1	2	1	1	3	4	2	3	3	0	1	1	3	0	4	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:100390887G>C	uc003pqh.1	-	4	840	c.525C>G	c.(523-525)ATC>ATG	p.I175M	MCHR2_uc003pqi.1_Missense_Mutation_p.I175M	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	175	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTTTAAATTTGATGACCTTCG	0.433													42	143					0	0	0	0	C	100390887	C	C	100390887	3	2	29	1	0	0	0	0	1	0	0	0	9436	1280	45	2	509	2	MCHR2	6	100390887	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	14066270	100390887	70724180	191	5725											
SIM1	6492	broad.mit.edu	37	chr6	100841606	100841606	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagccatagcagagagagcTgcggtccgaaaactgtctgt	13	7	12	9	2	1	2	0	0	1	2	2	4	2	2	2	1	5	2	2	1	4	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:100841606T>A	uc003pqj.3	-	10	1534	c.1327A>T	c.(1327-1329)AGC>TGC	p.S443C	SIM1_uc010kcu.2_Missense_Mutation_p.S443C	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	443	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CAGAGAGAGCTGCGGTCCGAA	0.622													92	66					0	0	0	0	A	100841606	A	A	100841606	3	1	29	1	0	0	0	0	1	0	0	0	14388	1580	55	5	981	5	SIM1	6	100841606	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	450719	100841606	70273461	192	5726											
TRAF3IP2	10758	broad.mit.edu	37	chr6	111912698	111912698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggggctgggaatcatatcCcgtgtctatggttggcagat	7	12	14	8	1	2	1	1	0	1	1	3	2	3	2	1	5	0	3	1	5	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:111912698C>T	uc011ebc.1	-	3	1207	c.592G>A	c.(592-594)GGA>AGA	p.G198R	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.G198R|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.G198R|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.G198R|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.G198R	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	207					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		GAATCATATCCCGTGTCTATG	0.622													39	96					0	0	0	0	T	111912698	T	T	111912698	3	4	29	1	0	0	0	0	1	0	0	0	16508	632	22	4	1137	4	TRAF3IP2	6	111912698	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	11071092	111912698	59202369	193	5727											
ROS1	6098	broad.mit.edu	37	chr6	117710680	117710681	+	Missense_Mutation	DNP	CC	AA	AA																															ctatgtgactcaggtcacatCccacgatgaattcattaaaa																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:117710680_117710681CC>AA	uc003pxp.1	-	12	1790_1791	c.1591_1592GG>TT	c.(1591-1593)GGA>TTA	p.G531L	ROS1_uc011ebi.1_Intron|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	531	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CAGGTCACATCCCACGATGAAT	0.455			T	GOPC|ROS1	glioblastoma|NSCLC								16	46					0	0	0	0	AA	117710681	AA	AA	117710680	3	1	29	1	0	0	0	0	1	0	0	0	13596	855	30	2	5579	2	ROS1	6	117710680	Missense_Mutation	DNP	CC	TCGA-BB-7862-01A-21D-2229-08	5797982	117710680	53404387	194	5728											
LAMA2	3908	broad.mit.edu	37	chr6	129714237	129714237	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaagaagctgtttggagagtCccggggggaaaatgaagaaa	15	6	16	4	1	0	4	0	1	0	3	1	7	1	5	1	4	1	2	1	4	6	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:129714237C>T	uc003qbn.2	+	37	5387	c.5282C>T	c.(5281-5283)TCC>TTC	p.S1761F	LAMA2_uc003qbo.2_Missense_Mutation_p.S1761F	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1761	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTTGGAGAGTCCCGGGGGGAA	0.468													22	34					0	0	0	0	T	129714237	T	T	129714237	3	4	29	1	0	0	0	0	1	0	0	0	8646	855	30	2	5428	2	LAMA2	6	129714237	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	12003557	129714237	41400830	195	5729											
AKAP7	9465	broad.mit.edu	37	chr6	131520611	131520611	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttcttcagagactgcaaaTaggacatttcaagaaaaagg	16	11	8	6	0	3	2	2	0	1	2	3	4	3	3	0	2	1	1	0	2	5	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:131520611T>C	uc003qck.2	+	6	633	c.600T>C	c.(598-600)AAT>AAC	p.N200N	AKAP7_uc011ebz.1_Silent_p.N178N|AKAP7_uc003qcl.1_Silent_p.N81N	NM_016377	NP_057461	O43687	AKA7A_HUMAN	A-kinase anchor protein 7 isoform gamma	Error:Variant_position_missing_in_O43687_after_alignment					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			ovary(2)	2	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)		AGACTGCAAATAGGACATTTC	0.348													10	25					0	0	0	0	C	131520611	C	C	131520611	2	2	29	1	0	0	0	0	0	0	0	1	456	1403	49	5		5	AKAP7	6	131520611	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	1806374	131520611	39594456	196	5730											
GRM1	2911	broad.mit.edu	37	chr6	146755255	146755256	+	Missense_Mutation	DNP	CC	AA	AA																															cccagccgattcgctttagcCcgcctggtagcccttccatg																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:146755255_146755256CC>AA	uc010khw.1	+	9	3378_3379	c.2908_2909CC>AA	c.(2908-2910)CCG>AAG	p.P970K	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	970	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TCGCTTTAGCCCGCCTGGTAGC	0.619													72	111					0	0	0	0	AA	146755256	AA	AA	146755255	3	1	29	1	0	0	0	0	1	0	0	0	6835	623	22	4	3003	4	GRM1	6	146755255	Missense_Mutation	DNP	CC	TCGA-BB-7862-01A-21D-2229-08	15234644	146755255	24359812	197	5731											
C6orf97	80129	broad.mit.edu	37	chr6	151894603	151894603	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagattcgagaaatggacAgccgggaagaaagcagggac	17	3	15	6	2	0	4	0	0	0	4	1	8	0	7	1	3	2	1	1	3	4	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:151894603A>G	uc003qol.2	+	6	1158	c.1069A>G	c.(1069-1071)AGC>GGC	p.S357G		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	357											0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		AGAAATGGACAGCCGGGAAGA	0.478													31	42					0	0	0	0	G	151894603	G	G	151894603	3	3	29	1	0	0	0	0	1	0	0	0	2385	188	7	5	1091	5	C6orf97	6	151894603	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	5139348	151894603	19220464	198	5732											
SYNE1	23345	broad.mit.edu	37	chr6	152772324	152772324	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gatgaagcaaatgataagggGcttctccttgaagatcctac	13	10	10	8	0	1	4	0	3	1	1	3	5	2	4	2	2	2	2	2	2	5	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:152772324G>T	uc010kiw.2	-	26	3646	c.3044C>A	c.(3043-3045)GCC>GAC	p.A1015D	SYNE1_uc003qot.3_Missense_Mutation_p.A1022D|SYNE1_uc003qou.3_Missense_Mutation_p.A1015D|SYNE1_uc010kjb.1_Missense_Mutation_p.A998D|SYNE1_uc003qow.2_Missense_Mutation_p.A310D|SYNE1_uc003qox.1_Missense_Mutation_p.A531D	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1015	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGATAAGGGGCTTCTCCTTG	0.393										HNSCC(10;0.0054)			18	35					1.40151e-16	1.73732e-16	1	0	T	152772324	T	T	152772324	3	4	29	1	0	0	0	0	1	0	0	0	15511	1203	42	4	23906	4	SYNE1	6	152772324	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	877721	152772324	18342743	199	5733											
SYNE1	23345	broad.mit.edu	37	chr6	152792750	152792750	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accacgtagttttgtagaagCtgctccactgactctctcct	8	13	7	13	1	1	2	0	1	1	1	4	2	3	2	3	0	2	5	3	0	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:152792750C>G	uc010kiw.2	-	16	2216	c.1614G>C	c.(1612-1614)CAG>CAC	p.Q538H	SYNE1_uc003qot.3_Missense_Mutation_p.Q545H|SYNE1_uc003qou.3_Missense_Mutation_p.Q538H|SYNE1_uc010kjb.1_Missense_Mutation_p.Q521H|SYNE1_uc003qpa.1_Missense_Mutation_p.Q538H|SYNE1_uc003qox.1_Missense_Mutation_p.Q54H|SYNE1_uc003qoz.2_5'UTR|SYNE1_uc003qoy.2_Missense_Mutation_p.Q105H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	538	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTGTAGAAGCTGCTCCACTG	0.433										HNSCC(10;0.0054)			61	122					0	0	0	0	G	152792750	G	G	152792750	3	3	29	1	0	0	0	0	1	0	0	0	15511	796	28	4	25376	4	SYNE1	6	152792750	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	20426	152792750	18322317	200	5734											
SYNJ2	8871	broad.mit.edu	37	chr6	158510920	158510920	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttataatgtcaagcagatcaAaaccaccaatgcccaggagg	16	7	8	10	0	2	1	2	0	0	1	2	2	2	2	3	2	3	1	3	2	6	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:158510920A>T	uc003qqx.1	+	25	3581	c.3506A>T	c.(3505-3507)AAA>ATA	p.K1169I	SYNJ2_uc003qqw.1_Missense_Mutation_p.K1169I|SYNJ2_uc003qqy.1_Missense_Mutation_p.K882I|SYNJ2_uc003qqz.1_Missense_Mutation_p.K786I|SYNJ2_uc003qra.1_Missense_Mutation_p.K512I|SYNJ2_uc010kjp.1_Missense_Mutation_p.K52I	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1169	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		AAGCAGATCAAAACCACCAAT	0.522													17	14					0	0	0	0	T	158510920	T	T	158510920	3	4	29	1	0	0	0	0	1	0	0	0	15519	14	1	5	3604	5	SYNJ2	6	158510920	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	5718170	158510920	12604147	201	5735											
FNDC1	84624	broad.mit.edu	37	chr6	159654497	159654497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctcgtccgcccgcagcaCggtcacagcagcatcccagt	7	6	10	18	4	1	0	1	0	0	0	4	0	3	0	3	1	4	5	3	1	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:159654497C>T	uc010kjv.2	+	11	3153	c.2953C>T	c.(2953-2955)CGG>TGG	p.R985W	FNDC1_uc010kjw.1_Missense_Mutation_p.R870W	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	985						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCCCGCAGCACGGTCACAGCA	0.677													8	10					0	0	0	0	T	159654497	T	T	159654497	3	4	29	1	0	0	0	0	1	0	0	0	6000	527	19	1	2995	1	FNDC1	6	159654497	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1143577	159654497	11460570	202	5736											
PDE10A	10846	broad.mit.edu	37	chr6	165792847	165792847	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agagtggagaagatattgtgCccttccaactagggaaaaaa	16	8	11	6	0	0	3	0	0	0	3	1	5	1	4	2	2	2	0	2	2	7	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:165792847C>T	uc003qun.2	-	19	2032	c.1791G>A	c.(1789-1791)GGG>GGA	p.G597G	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Silent_p.G527G|PDE10A_uc003quo.2_Silent_p.G607G	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	597					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	AGATATTGTGCCCTTCCAACT	0.378													13	27					0	0	0	0	T	165792847	T	T	165792847	2	4	29	1	0	0	0	0	0	0	0	1	11684	726	26	4		4	PDE10A	6	165792847	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	6138350	165792847	5322220	203	5737											
C6orf120	387263	broad.mit.edu	37	chr6	170102778	170102784	+	Frame_Shift_Del	DEL	GATGCGG	-	-																															ggatgcgcagcctcaagggaGatgcggatctgtacgtctcc																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr6:170102778_170102784delGATGCGG	uc003qxb.2	+	1	522_528	c.223_229delGATGCGG	c.(223-231)GATGCGGATfs	p.D75fs	WDR27_uc010kkw.1_5'Flank|WDR27_uc003qwx.2_5'Flank|WDR27_uc003qwy.2_5'Flank|WDR27_uc011egw.1_5'Flank|WDR27_uc010kkx.2_5'Flank|C6orf120_uc011egx.1_Frame_Shift_Del_p.D94fs	NM_001029863	NP_001025034	Q7Z4R8	CF120_HUMAN	hypothetical protein LOC387263 precursor	75_77						extracellular region					0		Breast(66;0.000338)		OV - Ovarian serous cystadenocarcinoma(33;9.65e-22)|BRCA - Breast invasive adenocarcinoma(81;1.29e-07)|GBM - Glioblastoma multiforme(31;0.0015)		CCTCAAGGGAGATGCGGATCTGTACGT	0.652													---	---	---								-	170102784	-	-	170102778	7	5	29	1	0	1	0	1	0	0	0	0	2334	942	33	0	225	0	C6orf120	6	170102778	Frame_Shift_Del	DEL	GATGCGG	TCGA-BB-7862-01A-21D-2229-08	4309931	170102778	1012289	204	5738											
EIF2AK1	27102	broad.mit.edu	37	chr7	6080705	6080705	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagttcaccagattctcttaTgactaaattggtggtgtact	11	15	8	7	0	2	2	1	1	1	1	3	2	2	2	1	2	1	2	1	2	5	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:6080705T>A	uc003spp.2	-	9	1083	c.937A>T	c.(937-939)ATA>TTA	p.I313L	EIF2AK1_uc003spq.2_Missense_Mutation_p.I312L|EIF2AK1_uc011jwm.1_Missense_Mutation_p.I189L|EIF2AK1_uc003spr.1_Missense_Mutation_p.I105L	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	313	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		GATTCTCTTATGACTAAATTG	0.458													77	142					0	0	0	0	A	6080705	A	A	6080705	3	1	29	1	0	0	0	0	1	0	0	0	5018	1464	51	5	983	5	EIF2AK1	7	6080705	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08		6080705	153057958	205	5739											
THSD7A	221981	broad.mit.edu	37	chr7	11450926	11450926	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttccacaaactgccttctCactcagctgacatgtactcc	10	12	4	15	0	2	1	2	1	1	0	5	1	4	1	3	0	4	2	3	0	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:11450926C>A	uc003ssf.3	-	18	3958	c.3706G>T	c.(3706-3708)GAG>TAG	p.E1236*		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1236	TSP type-1 12.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ACTGCCTTCTCACTCAGCTGA	0.413										HNSCC(18;0.044)			14	27					7.93312e-07	8.52138e-07	1	0	A	11450926	A	A	11450926	4	1	29	1	0	0	0	0	0	1	0	0	15945	835	29	2	1307	2	THSD7A	7	11450926	Nonsense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	5370221	11450926	147687737	206	5740											
THSD7A	221981	broad.mit.edu	37	chr7	11500374	11500374	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggactaattggcatctgcgCcatttgtgagtcttccacct	7	13	10	11	1	2	1	0	1	2	0	3	2	3	2	3	2	1	1	3	2	1	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:11500374C>A	uc003ssf.3	-	11	2772	c.2520G>T	c.(2518-2520)TGG>TGT	p.W840C		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	840	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GGCATCTGCGCCATTTGTGAG	0.547										HNSCC(18;0.044)			6	22					3.59834e-05	3.74611e-05	1	0	A	11500374	A	A	11500374	3	1	29	1	0	0	0	0	1	0	0	0	15945	740	26	4	2521	4	THSD7A	7	11500374	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	49448	11500374	147638289	207	5741											
HDAC9	9734	broad.mit.edu	37	chr7	18788696	18788696	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attccaccacccaccctgagCatgctggacgaatacagagt	12	7	8	14	1	0	2	0	1	0	1	1	4	1	3	4	1	3	2	4	1	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:18788696C>A	uc003suh.2	+	13	2010	c.1969C>A	c.(1969-1971)CAT>AAT	p.H657N	HDAC9_uc003sue.2_Missense_Mutation_p.H657N|HDAC9_uc011jyd.1_Missense_Mutation_p.H657N|HDAC9_uc003sui.2_Missense_Mutation_p.H660N|HDAC9_uc003suj.2_Missense_Mutation_p.H616N|HDAC9_uc003sua.1_Missense_Mutation_p.H635N|HDAC9_uc010kue.1_Missense_Mutation_p.H312N	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	657	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CCACCCTGAGCATGCTGGACG	0.448													14	30					0.000219431	0.000225663	1	0	A	18788696	A	A	18788696	3	1	29	1	0	0	0	0	1	0	0	0	7053	710	25	4	2079	4	HDAC9	7	18788696	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	7288322	18788696	140349967	208	5742											
DNAH11	8701	broad.mit.edu	37	chr7	21654860	21654860	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagaaataaaattgctcaaGggactgtgggatgtcattat	16	11	10	4	0	2	1	2	0	0	1	2	3	2	3	0	2	1	1	0	2	6	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:21654860G>A	uc003svc.2	+	21	4012	c.3981G>A	c.(3979-3981)AAG>AAA	p.K1327K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1327	Potential.|Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AATTGCTCAAGGGACTGTGGG	0.353									Kartagener_syndrome				25	38					0	0	0	0	A	21654860	A	A	21654860	2	1	29	1	0	0	0	0	0	0	0	1	4621	991	35	4		4	DNAH11	7	21654860	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2866164	21654860	137483803	209	5743											
AMPH	273	broad.mit.edu	37	chr7	38574590	38574590	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcgtcttttgtctcatcagCtttccccagcttttggagga	5	17	8	11	1	3	0	2	0	2	0	6	2	4	2	2	2	2	2	2	2	0	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:38574590C>A	uc003tgu.2	-	2	160	c.91G>T	c.(91-93)GCT>TCT	p.A31S	AMPH_uc003tgv.2_Missense_Mutation_p.A31S	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	31	BAR.|Potential.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						GTCTCATCAGCTTTCCCCAGC	0.348													16	28					3.62473e-10	4.08386e-10	1	0	A	38574590	A	A	38574590	3	1	29	1	0	0	0	0	1	0	0	0	588	797	28	4	2076	4	AMPH	7	38574590	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	16919730	38574590	120564073	210	5744											
ZNF716	441234	broad.mit.edu	37	chr7	57529304	57529304	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attcatactggagagaaaccCtacacttgtgaagaatgtgg	14	10	10	7	0	1	3	1	1	0	2	1	5	1	4	1	2	3	0	1	2	5	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:57529304C>T	uc011kdi.1	+	4	1249	c.1137C>T	c.(1135-1137)CCC>CCT	p.P379P		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						GAGAGAAACCCTACACTTGTG	0.413													3	6					0	0	0	0	T	57529304	T	T	57529304	2	4	29	1	0	0	0	0	0	0	0	1	18186	668	24	4		4	ZNF716	7	57529304	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	18954714	57529304	101609359	211	5745											
NSUN5	55695	broad.mit.edu	37	chr7	72717963	72717963	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggctcgctgctggaacccTgccagggcatgcagacgcac	8	5	14	14	2	0	1	0	0	0	1	1	2	0	2	2	3	4	6	2	3	1	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:72717963T>A	uc003txw.2	-	8	1041	c.1005A>T	c.(1003-1005)GCA>GCT	p.A335A	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Silent_p.A335A|NSUN5_uc003txx.2_Silent_p.A297A|NSUN5_uc011kev.1_Silent_p.A335A	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	335							methyltransferase activity				0		Lung NSC(55;0.163)				GCTGGAACCCTGCCAGGGCAT	0.622													21	53					0	0	0	0	A	72717963	A	A	72717963	2	1	29	1	0	0	0	0	0	0	0	1	10735	1567	55	5		5	NSUN5	7	72717963	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	15188659	72717963	86420700	212	5746											
GRM3	2913	broad.mit.edu	37	chr7	86415998	86415998	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgccaatgcctccttcacctGggtggccagcgacggctggg	5	7	14	15	3	1	0	1	0	0	0	2	1	2	0	5	4	2	1	5	4	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:86415998G>C	uc003uid.2	+	3	1989	c.890G>C	c.(889-891)TGG>TCG	p.W297S	GRM3_uc010lef.2_Missense_Mutation_p.W295S|GRM3_uc010leg.2_Missense_Mutation_p.W169S|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	297	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TCCTTCACCTGGGTGGCCAGC	0.682													31	54					0	0	0	0	C	86415998	C	C	86415998	3	2	29	1	0	0	0	0	1	0	0	0	6837	1357	47	4	896	4	GRM3	7	86415998	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	13698035	86415998	72722665	213	5747											
PON1	5444	broad.mit.edu	37	chr7	94940875	94940875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggatggttcaccaccaggaGgtacatggcattatctgaga	11	10	12	8	0	2	1	1	1	1	1	2	4	2	3	2	5	1	3	2	5	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:94940875G>A	uc003uns.2	-	5	482	c.385C>T	c.(385-387)CTC>TTC	p.L129F	PON1_uc011kih.1_Missense_Mutation_p.L129F	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	129					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	ACCACCAGGAGGTACATGGCA	0.393													17	41					0	0	0	0	A	94940875	A	A	94940875	3	1	29	1	0	0	0	0	1	0	0	0	12303	1000	35	4	702	4	PON1	7	94940875	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	8524877	94940875	64197788	214	5748											
PON1	5444	broad.mit.edu	37	chr7	94944689	94944689	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatgaagatacatcaaatttActtccagtgatccccaattc	15	12	4	10	0	1	3	1	2	0	1	4	3	3	3	3	0	2	0	3	0	6	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:94944689A>T	uc003uns.2	-	4	412	c.315T>A	c.(313-315)AGT>AGA	p.S105R	PON1_uc011kih.1_Missense_Mutation_p.S105R	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	105					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	CATCAAATTTACTTCCAGTGA	0.358													16	48					0	0	0	0	T	94944689	T	T	94944689	3	4	29	1	0	0	0	0	1	0	0	0	12303	388	14	5	776	5	PON1	7	94944689	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	3814	94944689	64193974	215	5749											
CYP3A4	1576	broad.mit.edu	37	chr7	99367466	99367466	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acacatctccatactgggcaAtgatagggaccatctaagca	14	8	8	11	0	2	1	0	1	2	0	3	2	2	2	2	2	2	2	2	2	4	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:99367466A>G	uc003urv.1	-	6	550	c.446T>C	c.(445-447)ATT>ACT	p.I149T	CYP3A4_uc003urw.1_Missense_Mutation_p.I149T|CYP3A4_uc011kiz.1_Intron|CYP3A4_uc011kja.1_Missense_Mutation_p.I100T|CYP3A4_uc011kjb.1_Intron	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	149					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	ATACTGGGCAATGATAGGGAC	0.498													37	69					0	0	0	0	G	99367466	G	G	99367466	3	3	29	1	0	0	0	0	1	0	0	0	4195	101	4	5	1097	5	CYP3A4	7	99367466	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	4422777	99367466	59771197	216	5750											
SERPINE1	5054	broad.mit.edu	37	chr7	100776987	100776987	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcacagctgagttcaccAcgcccgatggccattactac	9	10	7	15	2	3	1	2	1	1	0	3	2	3	1	3	1	3	2	3	1	2	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:100776987A>G	uc003uxt.2	+	5	860	c.712A>G	c.(712-714)ACG>GCG	p.T238A	SERPINE1_uc011kkj.1_Missense_Mutation_p.T223A|SERPINE1_uc003uxu.1_Missense_Mutation_p.T69A	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	238					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	TGAGTTCACCACGCCCGATGG	0.547													41	73					0	0	0	0	G	100776987	G	G	100776987	3	3	29	1	0	0	0	0	1	0	0	0	14176	159	6	5	726	5	SERPINE1	7	100776987	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	1409521	100776987	58361676	217	5751											
TMEM168	64418	broad.mit.edu	37	chr7	112423756	112423756	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acaaacaataagcttacctgCcaggaaactgctcccaaaat	17	7	5	12	0	0	0	0	0	0	0	1	1	1	1	3	1	6	2	3	1	7	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:112423756C>A	uc003vgn.2	-	2	1517	c.1125G>T	c.(1123-1125)TGG>TGT	p.W375C	TMEM168_uc010lju.2_Missense_Mutation_p.W375C|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	375						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						AGCTTACCTGCCAGGAAACTG	0.398													30	57					3.03874e-20	3.86126e-20	1	0	A	112423756	A	A	112423756	3	1	29	1	0	0	0	0	1	0	0	0	16149	740	26	4	984	4	TMEM168	7	112423756	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	11646769	112423756	46714907	218	5752											
SLC35B4	84912	broad.mit.edu	37	chr7	133979788	133979788	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcgtgacggtgagggaggCgcattctgtggtgaggataa	9	8	19	5	3	1	3	0	3	1	0	1	6	1	5	0	5	1	1	0	5	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:133979788C>A	uc003vrn.2	-	10	1117	c.793G>T	c.(793-795)GCC>TCC	p.A265S	SLC35B4_uc010lmk.2_Missense_Mutation_p.A129S|SLC35B4_uc010lml.1_Intron	NM_032826	NP_116215	Q969S0	S35B4_HUMAN	solute carrier family 35, member B4	265	Helical; (Potential).					Golgi membrane|integral to membrane	UDP-N-acetylglucosamine transmembrane transporter activity|UDP-xylose transmembrane transporter activity			skin(1)	1						GTGAGGGAGGCGCATTCTGTG	0.532													133	263					1.86983e-63	2.64806e-63	1	0	A	133979788	A	A	133979788	3	1	29	1	0	0	0	0	1	0	0	0	14642	768	27	3	206	3	SLC35B4	7	133979788	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	21556032	133979788	25158875	219	5753											
SLC13A4	26266	broad.mit.edu	37	chr7	135378956	135378956	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttcccttttggtcttcttCttcttgctcagagagcaggt	4	18	9	10	0	5	1	1	0	4	1	6	2	6	1	1	2	2	3	1	2	0	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:135378956C>G	uc003vta.2	-	10	1736	c.1047G>C	c.(1045-1047)AAG>AAC	p.K349N	SLC13A4_uc003vtb.2_Missense_Mutation_p.K350N	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	349						integral to plasma membrane	sodium:sulfate symporter activity				0						TGGTCTTCTTCTTCTTGCTCA	0.403													30	58					0	0	0	0	G	135378956	G	G	135378956	3	3	29	1	0	0	0	0	1	0	0	0	14459	912	32	2	861	2	SLC13A4	7	135378956	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1399168	135378956	23759707	220	5754											
OR6V1	346517	broad.mit.edu	37	chr7	142750181	142750181	+	Frame_Shift_Del	DEL	C	-	-																															cacctcacactggtcttcatCggctacagtagtaccatctt																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:142750181delC	uc011ksv.1	+	1	744	c.744delC	c.(742-744)ATCfs	p.I248fs		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					TGGTCTTCATCGGCTACAGTA	0.552													---	---	---								-	142750181	-	-	142750181	7	5	29	1	0	1	0	1	0	0	0	0	11265	874	31	0	746	0	OR6V1	7	142750181	Frame_Shift_Del	DEL	C	TCGA-BB-7862-01A-21D-2229-08	7371225	142750181	16388482	221	5755											
TMEM176B	28959	broad.mit.edu	37	chr7	150490256	150490256	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcatccatctgtacccagTggtagggaagacagggtctg	9	8	13	11	1	2	1	0	0	2	1	3	2	3	2	3	3	1	3	3	3	3	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:150490256T>C	uc003wht.3	-	5	686	c.520A>G	c.(520-522)ACT>GCT	p.T174A	TMEM176B_uc003whu.3_Missense_Mutation_p.T174A|TMEM176B_uc003whv.3_Missense_Mutation_p.T137A|TMEM176B_uc003whw.3_Missense_Mutation_p.T174A	NM_001101313	NP_001094783	Q3YBM2	T176B_HUMAN	transmembrane protein 176B isoform a	174					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGTACCCAGTGGTAGGGAAG	0.512													27	56					0	0	0	0	C	150490256	C	C	150490256	3	2	29	1	0	0	0	0	1	0	0	0	16159	1696	59	5	304	5	TMEM176B	7	150490256	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	7740075	150490256	8648407	222	5756											
RNF32	140545	broad.mit.edu	37	chr7	156450872	156450872	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aataagaaaacctgtcctctCtgtagaaagaaccagtatca	17	9	6	9	0	2	3	1	0	1	3	4	3	3	3	3	0	2	2	3	0	8	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr7:156450872C>T	uc003wmo.2	+	6	683	c.501C>T	c.(499-501)CTC>CTT	p.L167L	RNF32_uc010lql.1_RNA|RNF32_uc010lqm.2_Silent_p.L167L|RNF32_uc003wmq.2_Silent_p.L167L|RNF32_uc003wmr.2_Silent_p.L167L|RNF32_uc003wms.2_Silent_p.L167L|RNF32_uc003wmu.2_RNA|RNF32_uc003wmt.2_Silent_p.L167L	NM_030936	NP_112198	Q9H0A6	RNF32_HUMAN	ring finger protein 32	167	RING-type 1; atypical.					aggresome|endosome	protein binding|zinc ion binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		CCTGTCCTCTCTGTAGAAAGA	0.428													9	27					0	0	0	0	T	156450872	T	T	156450872	2	4	29	1	0	0	0	0	0	0	0	1	13553	900	32	2		2	RNF32	7	156450872	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	5960616	156450872	2687791	223	5757											
BNIP3L	665	broad.mit.edu	37	chr8	26238681	26238681	+	5'Flank	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtcattcgaagatctggAtccaatacagtatgattaca	15	12	7	7	1	2	2	1	1	1	1	4	4	3	3	1	1	2	1	1	1	6	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:26238681A>T	uc003xex.1	+						uc003xew.2_RNA|BNIP3L_uc010luh.1_5'Flank|BNIP3L_uc010lui.1_5'Flank	NM_004331	NP_004322	O60238	BNI3L_HUMAN	BCL2/adenovirus E1B 19kD-interacting protein						apoptosis|defense response to virus|induction of apoptosis|interspecies interaction between organisms|mitochondrial protein catabolic process|negative regulation of survival gene product expression	endoplasmic reticulum|integral to membrane|mitochondrial outer membrane|nuclear envelope	lamin binding|protein heterodimerization activity|protein homodimerization activity				0		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0019)|Epithelial(17;1.59e-12)|all cancers(2;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(2;2.57e-08)|Colorectal(74;0.135)		GAAGATCTGGATCCAATACAG	0.373													20	15					0	0	0	0	T	26238681	T	T	26238681	1	4	29	0	1	0	0	0	0	0	0	0	1482	348	12	5		5	BNIP3L	8	26238681	5'Flank	SNP	A	TCGA-BB-7862-01A-21D-2229-08		26238681	120125341	224	5758											
RAB11FIP1	80223	broad.mit.edu	37	chr8	37729787	37729787	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccgtcagacgcgtttccagCaacagaccatgcagggttca	10	8	10	13	3	2	2	2	0	0	2	4	2	4	2	3	1	3	4	3	1	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:37729787C>A	uc003xkm.1	-	4	2577	c.2533G>T	c.(2533-2535)GCT>TCT	p.A845S	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.A174S|RAB11FIP1_uc003xko.1_Missense_Mutation_p.A174S|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	845					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			GCGTTTCCAGCAACAGACCAT	0.622													83	44					1.61229e-46	2.25187e-46	1	0	A	37729787	A	A	37729787	3	1	29	1	0	0	0	0	1	0	0	0	12958	710	25	4	1330	4	RAB11FIP1	8	37729787	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	11491106	37729787	108634235	225	5759											
RAB11FIP1	80223	broad.mit.edu	37	chr8	37756684	37756684	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgagcagcgcgcggtgcagCacggtgagctgcagggtggc	6	4	19	12	5	0	1	0	1	0	0	0	2	0	1	1	4	6	5	1	4	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:37756684C>T	uc003xkm.1	-	1	320	c.276G>A	c.(274-276)GTG>GTA	p.V92V	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Silent_p.V92V	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	92	C2.				protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CGCGGTGCAGCACGGTGAGCT	0.741													11	10					0	0	0	0	T	37756684	T	T	37756684	2	4	29	1	0	0	0	0	0	0	0	1	12958	697	25	4		4	RAB11FIP1	8	37756684	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	26897	37756684	108607338	226	5760											
NPBWR1	2831	broad.mit.edu	37	chr8	53853443	53853443	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagctgataacttgccgcGcggcagcctgactcccccag	7	6	11	17	3	0	2	0	2	0	0	1	2	1	2	5	1	4	2	5	1	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:53853443G>T	uc011ldu.1	+	1	976	c.976G>T	c.(976-978)GCG>TCG	p.A326S		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	326	Cytoplasmic (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				AACTTGCCGCGCGGCAGCCTG	0.697													9	24					0.000442599	0.000453329	1	0	T	53853443	T	T	53853443	3	4	29	1	0	0	0	0	1	0	0	0	10622	1087	38	3	978	3	NPBWR1	8	53853443	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	16096759	53853443	92510579	227	5761											
RP1	6101	broad.mit.edu	37	chr8	55539327	55539327	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgatccccatacaaattctgGaaaaataagtaattttgtta	16	14	5	6	0	1	1	0	1	1	0	2	2	2	2	2	1	1	2	2	1	7	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:55539327G>A	uc003xsd.1	+	4	3033	c.2885G>A	c.(2884-2886)GGA>GAA	p.G962E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	962					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACAAATTCTGGAAAAATAAGT	0.313													20	38					0	0	0	0	A	55539327	A	A	55539327	3	1	29	1	0	0	0	0	1	0	0	0	13597	1174	41	2	2895	2	RP1	8	55539327	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1685884	55539327	90824695	228	5762											
EYA1	2138	broad.mit.edu	37	chr8	72246403	72246403	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactgctgctcattggctctGttttaactacaaaaataaac	13	13	5	10	0	2	0	1	0	1	0	2	0	2	0	0	1	5	4	0	1	6	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:72246403G>C	uc003xys.3	-	3	418	c.131C>G	c.(130-132)ACA>AGA	p.T44R	EYA1_uc003xyr.3_Missense_Mutation_p.T44R|EYA1_uc003xyt.3_Missense_Mutation_p.T11R|EYA1_uc010lzf.2_5'UTR|EYA1_uc003xyu.2_Missense_Mutation_p.T44R|EYA1_uc011lfe.1_Missense_Mutation_p.T44R|EYA1_uc003xyv.2_5'UTR	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	44					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CATTGGCTCTGTTTTAACTAC	0.328													25	52					0	0	0	0	C	72246403	C	C	72246403	3	2	29	1	0	0	0	0	1	0	0	0	5353	1377	48	4	1707	4	EYA1	8	72246403	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	16707076	72246403	74117619	229	5763											
ZFHX4	79776	broad.mit.edu	37	chr8	77763218	77763218	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagaaaccgactaaagaacCcttggaagtctcagaatgga	16	6	10	9	1	1	3	1	0	1	3	2	6	1	5	2	2	2	1	2	2	6	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:77763218C>G	uc003yav.2	+	10	4313	c.3926C>G	c.(3925-3927)CCC>CGC	p.P1309R	ZFHX4_uc003yau.1_Missense_Mutation_p.P1354R|ZFHX4_uc003yaw.1_Missense_Mutation_p.P1309R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1309						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTAAAGAACCCTTGGAAGTC	0.418										HNSCC(33;0.089)			9	16					0	0	0	0	G	77763218	G	G	77763218	3	3	29	1	0	0	0	0	1	0	0	0	17702	623	22	4	4095	4	ZFHX4	8	77763218	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	5516815	77763218	68600804	230	5764											
MMP16	4325	broad.mit.edu	37	chr8	89068480	89068480	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtaaccaggttgaagagttgTatccttgaacacccaatatt	13	12	8	8	0	0	3	0	2	0	1	1	3	1	3	3	1	2	4	3	1	6	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:89068480T>A	uc003yeb.3	-	8	1531	c.1249A>T	c.(1249-1251)ACA>TCA	p.T417S		NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	417	Hemopexin-like 2.|Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TGAAGAGTTGTATCCTTGAAC	0.328													36	49					0	0	0	0	A	89068480	A	A	89068480	3	1	29	1	0	0	0	0	1	0	0	0	9708	1638	57	5	586	5	MMP16	8	89068480	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	11305262	89068480	57295542	231	5765											
SLC26A7	115111	broad.mit.edu	37	chr8	92378866	92378867	+	Frame_Shift_Ins	INS	-	A	A																															ccgcttgttttcctgaatgcINSaaaaaaattttatactgatt																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:92378866_92378867insA	uc003yex.2	+	15	1825_1826	c.1547_1548insA	c.(1546-1548)GCAfs	p.A516fs	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Frame_Shift_Ins_p.A516fs|SLC26A7_uc003yfa.2_Frame_Shift_Ins_p.A516fs	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	516	STAS.|Cytoplasmic (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TTCCTGAATGCAAAAAAATTTT	0.347													---	---	---								A	92378867	A	A	92378866	7	5	29	1	0	1	1	0	0	0	0	0	14586	710	25	0	1597	0	SLC26A7	8	92378866	Frame_Shift_Ins	INS	-	TCGA-BB-7862-01A-21D-2229-08	3310386	92378866	53985156	232	5766											
CSMD3	114788	broad.mit.edu	37	chr8	113249444	113249445	+	Frame_Shift_Ins	INS	-	T	T																															gtagcagctccatgttgctaINSttgctcagtgttgcgttaac																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:113249444_113249445insT	uc003ynu.2	-	67	10760_10761	c.10601_10602insA	c.(10600-10602)AATfs	p.N3534fs	CSMD3_uc003yns.2_Frame_Shift_Ins_p.N2736fs|CSMD3_uc003ynt.2_Frame_Shift_Ins_p.N3494fs|CSMD3_uc011lhx.1_Frame_Shift_Ins_p.N3365fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3534	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCATGTTGCTATTGCTCAGTGT	0.366										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---								T	113249445	T	T	113249444	7	5	29	1	0	1	1	0	0	0	0	0	3963	446	16	0	541	0	CSMD3	8	113249444	Frame_Shift_Ins	INS	-	TCGA-BB-7862-01A-21D-2229-08	20870578	113249444	33114578	233	5767											
CSMD3	114788	broad.mit.edu	37	chr8	113529397	113529397	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccaggttctcttccatccCcatttcgagtcccattcatg	6	13	5	17	1	2	0	1	0	1	0	7	1	5	0	6	1	0	1	6	1	0	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:113529397C>A	uc003ynu.2	-	28	4781	c.4622G>T	c.(4621-4623)GGG>GTG	p.G1541V	CSMD3_uc003yns.2_Missense_Mutation_p.G813V|CSMD3_uc003ynt.2_Missense_Mutation_p.G1501V|CSMD3_uc011lhx.1_Missense_Mutation_p.G1437V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1541	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCTTCCATCCCCATTTCGAGT	0.448										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			20	35					2.89027e-11	3.31531e-11	1	0	A	113529397	A	A	113529397	3	1	29	1	0	0	0	0	1	0	0	0	3963	623	22	4	6677	4	CSMD3	8	113529397	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	279953	113529397	32834625	234	5768											
CSMD3	114788	broad.mit.edu	37	chr8	114186129	114186129	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaacaccaggatttccacaAgagctactctgcaattctat	13	10	7	11	0	2	1	0	0	2	1	3	3	3	3	2	2	4	2	2	2	5	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr8:114186129A>G	uc003ynu.2	-	4	690	c.531T>C	c.(529-531)TCT>TCC	p.S177S	CSMD3_uc003ynt.2_Silent_p.S137S|CSMD3_uc011lhx.1_Silent_p.S177S|CSMD3_uc010mcx.1_Silent_p.S177S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	177	Extracellular (Potential).|Sushi 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GATTTCCACAAGAGCTACTCT	0.373										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	31					0	0	0	0	G	114186129	G	G	114186129	2	3	29	1	0	0	0	0	0	0	0	1	3963	59	3	5		5	CSMD3	8	114186129	Silent	SNP	A	TCGA-BB-7862-01A-21D-2229-08	656732	114186129	32177893	235	5769											
KANK1	23189	broad.mit.edu	37	chr9	730159	730159	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggacctcagaaggaaagcCaatcagcagcctggatgcct	12	5	13	11	0	2	1	2	0	0	1	2	4	2	4	4	4	4	1	4	4	3	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr9:730159C>T	uc003zgl.1	+	8	3456	c.2807C>T	c.(2806-2808)CCA>CTA	p.P936L	KANK1_uc003zgm.2_Missense_Mutation_p.P936L|KANK1_uc003zgn.1_Missense_Mutation_p.P936L|KANK1_uc003zgs.1_Missense_Mutation_p.P778L|KANK1_uc010mgx.1_5'Flank|KANK1_uc010mgy.1_5'Flank	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	936					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GAAGGAAAGCCAATCAGCAGC	0.547													25	15					0	0	0	0	T	730159	T	T	730159	3	4	29	1	0	0	0	0	1	0	0	0	8015	594	21	4	2817	4	KANK1	9	730159	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08		730159	140483272	236	5770											
GLDC	2731	broad.mit.edu	37	chr9	6602195	6602195	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacgatacacttctttccCagtggcatctctacaccaag	12	10	6	13	1	2	1	0	0	2	1	4	2	3	1	2	1	2	1	2	1	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr9:6602195C>A	uc003zkc.2	-	8	1262	c.1069G>T	c.(1069-1071)GGG>TGG	p.G357W		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	357					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	ACTTCTTTCCCAGTGGCATCT	0.453													14	16					9.16793e-09	1.00827e-08	1	0	A	6602195	A	A	6602195	3	1	29	1	0	0	0	0	1	0	0	0	6470	594	21	4	2065	4	GLDC	9	6602195	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	5872036	6602195	134611236	237	5771											
CDKN2A	1029	broad.mit.edu	37	chr9	21971017	21971017	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctcctcagccaggtccacgGgcagacggccccaggcatcg	7	4	13	17	3	1	1	1	0	0	1	4	1	3	1	5	4	1	3	5	4	0	0	rs121913386		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr9:21971017G>T	uc003zpk.2	-	2	553	c.341C>A	c.(340-342)CCC>CAC	p.P114H	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.A169A	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	114	ANK 4.		P -> L (in non-small cell lung carcinoma).|P -> S (found in some patients with melanoma; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.P114L(21)|p.?(13)|p.P114H(3)|p.H83fs*2(2)|p.P114S(2)|p.A68fs*3(1)|p.P114P(1)|p.V115fs*11(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGGTCCACGGGCAGACGGCC	0.731	P114L(SKMEL30_SKIN)|P114L(WM983B_SKIN)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			22	29					7.33628e-21	9.369e-21	1	0	T	21971017	T	T	21971017	3	4	29	1	0	0	0	0	1	0	0	0	3176	1232	43	4	137	4	CDKN2A	9	21971017	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	15368822	21971017	119242414	238	5772											
TOPORS	10210	broad.mit.edu	37	chr9	32541632	32541632	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgtggcaatatcacattccTtgtccagcacaccaaattca	12	11	6	12	0	2	0	2	0	0	0	4	0	4	0	3	1	1	2	3	1	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr9:32541632T>A	uc003zrb.2	-	3	3058	c.2891A>T	c.(2890-2892)AAG>ATG	p.K964M	TOPORS_uc003zrc.2_Missense_Mutation_p.K897M	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	964					DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		ATCACATTCCTTGTCCAGCAC	0.388													68	38					0	0	0	0	A	32541632	A	A	32541632	3	1	29	1	0	0	0	0	1	0	0	0	16437	1609	56	5	250	5	TOPORS	9	32541632	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	10570615	32541632	108671799	239	5773											
TRPM6	140803	broad.mit.edu	37	chr9	77377127	77377127	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcttctggtgctgttcaCtccgagaggaatcactgtca	7	12	10	12	1	4	1	3	0	1	1	5	3	5	2	2	2	2	3	2	2	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr9:77377127C>A	uc004ajl.1	-	26	4698	c.4460G>T	c.(4459-4461)AGT>ATT	p.S1487I	TRPM6_uc004ajk.1_Missense_Mutation_p.S1482I|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.S443I	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1487	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTGCTGTTCACTCCGAGAGGA	0.502													88	40					9.07295e-45	1.26373e-44	1	0	A	77377127	A	A	77377127	3	1	29	1	0	0	0	0	1	0	0	0	16657	565	20	4	1664	4	TRPM6	9	77377127	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	44835495	77377127	63836304	240	5774											
TLE1	7088	broad.mit.edu	37	chr9	84230971	84230971	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agctggactgctagaagcatCcttctttagcaggcgatttt	9	13	10	9	1	1	1	0	0	1	1	2	3	2	2	1	2	4	4	1	2	3	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr9:84230971C>G	uc004aly.2	-	11	1285	c.844G>C	c.(844-846)GAT>CAT	p.D282H	TLE1_uc004alz.2_Missense_Mutation_p.D292H|TLE1_uc011lsr.1_Missense_Mutation_p.D282H|TLE1_uc004ama.1_Missense_Mutation_p.D282H|TLE1_uc011lss.1_Missense_Mutation_p.D208H	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	282	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						CTAGAAGCATCCTTCTTTAGC	0.493													51	114					0	0	0	0	G	84230971	G	G	84230971	3	3	29	1	0	0	0	0	1	0	0	0	16004	855	30	2	1508	2	TLE1	9	84230971	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	6853844	84230971	56982460	241	5775											
PTPN3	5774	broad.mit.edu	37	chr9	112144045	112144045	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttccatagtgaccaacaCaccggttcgacctattccag	10	11	7	13	2	0	1	0	1	0	0	3	2	2	1	5	1	1	2	5	1	3	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr9:112144045C>T	uc004bed.2	-	25	2663	c.2551G>A	c.(2551-2553)GTG>ATG	p.V851M	PTPN3_uc004beb.2_Missense_Mutation_p.V720M|PTPN3_uc004bec.2_Missense_Mutation_p.V675M|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.V806M|PTPN3_uc011lwh.1_Missense_Mutation_p.V697M|PTPN3_uc011lwd.1_Missense_Mutation_p.V319M|PTPN3_uc011lwe.1_Missense_Mutation_p.V564M|PTPN3_uc011lwf.1_Missense_Mutation_p.V519M	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	851	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						GTGACCAACACACCGGTTCGA	0.537													37	64					0	0	0	0	T	112144045	T	T	112144045	3	4	29	1	0	0	0	0	1	0	0	0	12854	478	17	4	198	4	PTPN3	9	112144045	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	27913074	112144045	29069386	242	5776											
SVEP1	79987	broad.mit.edu	37	chr9	113168502	113168502	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccactgcattggcgacagaCggtggggacccacaggacaa	11	4	14	12	2	0	1	0	0	0	1	0	4	0	3	2	5	1	1	2	5	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr9:113168502C>T	uc010mtz.2	-	38	9715	c.9378G>A	c.(9376-9378)CCG>CCA	p.P3126P	SVEP1_uc010mty.2_Silent_p.P1052P	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3126	Sushi 29.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TGGCGACAGACGGTGGGGACC	0.527													101	47					0	0	0	0	T	113168502	T	T	113168502	2	4	29	1	0	0	0	0	0	0	0	1	15486	523	19	1		1	SVEP1	9	113168502	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1024457	113168502	28044929	243	5777											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123215784	123215784	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcagcctgccacccaggcaCcccgtgcaggttctctggcc	5	6	12	18	1	1	0	0	0	1	0	2	0	1	0	6	4	3	4	6	4	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr9:123215784C>T	uc004bkf.2	-	21	2924	c.2743G>A	c.(2743-2745)GTG>ATG	p.V915M	CDK5RAP2_uc004bke.2_Missense_Mutation_p.V200M|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.V915M|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.V180M|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.V180M|CDK5RAP2_uc011lya.1_Missense_Mutation_p.V180M|CDK5RAP2_uc004bkh.1_Intron|CDK5RAP2_uc004bki.2_Missense_Mutation_p.V682M	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	915					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CACCCAGGCACCCCGTGCAGG	0.483													46	139					0	0	0	0	T	123215784	T	T	123215784	3	4	29	1	0	0	0	0	1	0	0	0	3161	507	18	4	3010	4	CDK5RAP2	9	123215784	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	10047282	123215784	17997647	244	5778											
TUBAL3	79861	broad.mit.edu	37	chr10	5435740	5435740	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggcggccgattgttgatgcCcaccttgaaaccagttggac	8	9	13	11	2	0	2	0	2	0	0	0	4	0	3	4	3	2	2	4	3	1	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:5435740C>A	uc001ihy.2	-	4	1121	c.1081G>T	c.(1081-1083)GGC>TGC	p.G361C	TUBAL3_uc001ihz.2_Missense_Mutation_p.G321C	NM_024803	NP_079079	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	361					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1						TTGTTGATGCCCACCTTGAAA	0.582													22	29					3.28513e-13	3.84656e-13	1	0	A	5435740	A	A	5435740	3	1	29	1	0	0	0	0	1	0	0	0	16819	623	22	4	263	4	TUBAL3	10	5435740	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08		5435740	130099007	245	5779											
GATA3	2625	broad.mit.edu	37	chr10	8115940	8115940	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcacccgccatccagcctgtCctttggaccacaccacccct	7	7	6	21	1	0	0	0	0	0	0	2	1	2	1	9	1	1	1	9	1	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:8115940C>T	uc001ika.2	+	6	1843	c.1286C>T	c.(1285-1287)TCC>TTC	p.S429F	GATA3_uc001ijz.2_Missense_Mutation_p.S430F	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	429					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						TCCAGCCTGTCCTTTGGACCA	0.642			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						71	145					0	0	0	0	T	8115940	T	T	8115940	3	4	29	1	0	0	0	0	1	0	0	0	6290	855	30	2	1307	2	GATA3	10	8115940	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2680200	8115940	127418807	246	5780											
MRC1	4360	broad.mit.edu	37	chr10	17949652	17949652	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagctttacatgcgtcttCtgggttttggagtaatattc	7	18	10	6	1	2	0	0	0	2	0	3	1	2	1	0	2	3	4	0	2	4	9			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:17949652C>A	uc001ipk.2	+	28	4119	c.4016C>A	c.(4015-4017)TCT>TAT	p.S1339Y		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	1339	Extracellular (Potential).|C-type lectin 8.				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						CATGCGTCTTCTGGGTTTTGG	0.413													55	124					8.20758e-20	1.04031e-19	1	0	A	17949652	A	A	17949652	3	1	29	1	0	0	0	0	1	0	0	0	9809	913	32	2	4126	2	MRC1	10	17949652	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	9833712	17949652	117585095	247	5781											
APBB1IP	54518	broad.mit.edu	37	chr10	26849703	26849703	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taccagcgggctgtggcaaaGgctggacttgcctctcggtg	6	9	15	11	2	1	0	0	0	1	0	2	1	1	1	2	5	3	3	2	5	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:26849703G>A	uc001iss.2	+	13	1620	c.1299G>A	c.(1297-1299)AAG>AAA	p.K433K		NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	433					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CTGTGGCAAAGGCTGGACTTG	0.493													34	72					0	0	0	0	A	26849703	A	A	26849703	2	1	29	1	0	0	0	0	0	0	0	1	760	991	35	4		4	APBB1IP	10	26849703	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	8900051	26849703	108685044	248	5782											
ERCC6	2074	broad.mit.edu	37	chr10	50690805	50690805	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctccataaacacaggcaaCgtgcctaactttcccgggaa	12	8	8	13	2	0	0	0	0	0	0	2	1	2	1	3	2	5	2	3	2	5	3	rs75166536		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:50690805C>A	uc001jhs.3	-	10	2251	c.2097G>T	c.(2095-2097)ACG>ACT	p.T699T	ERCC6_uc010qgr.1_Silent_p.T69T|ERCC6_uc001jhr.3_Silent_p.T99T	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	699					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						ACACAGGCAACGTGCCTAACT	0.483								Direct_reversal_of_damage|NER					28	61					1.26454e-06	1.35544e-06	1	0	A	50690805	A	A	50690805	2	1	29	1	0	0	0	0	0	0	0	1	5241	523	19	3		3	ERCC6	10	50690805	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	23841102	50690805	84843942	249	5783											
BICC1	80114	broad.mit.edu	37	chr10	60558967	60558967	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccatatcaacagtatgcaGaccgaaggcaaaaaaatctc	17	7	7	10	1	2	1	1	0	1	1	4	2	3	1	2	1	2	3	2	1	7	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:60558967G>T	uc001jki.1	+	12	1680	c.1680G>T	c.(1678-1680)CAG>CAT	p.Q560H	BICC1_uc001jkj.1_Missense_Mutation_p.Q201H	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	560					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						ACAGTATGCAGACCGAAGGCA	0.453													7	14					8.12818e-05	8.41018e-05	1	0	T	60558967	T	T	60558967	3	4	29	1	0	0	0	0	1	0	0	0	1430	933	33	2	1726	2	BICC1	10	60558967	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	9868162	60558967	74975780	250	5784											
PHYHIPL	84457	broad.mit.edu	37	chr10	60998404	60998404	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctgaagtgattgcaggaCgcatgcttaagttttctgtt	9	14	12	6	1	1	2	0	2	1	0	1	3	1	3	0	2	2	6	0	2	2	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:60998404C>A	uc001jkk.3	+	4	801	c.535C>A	c.(535-537)CGC>AGC	p.R179S	PHYHIPL_uc001jkl.3_Missense_Mutation_p.R133S|PHYHIPL_uc001jkm.3_Missense_Mutation_p.R153S	NM_032439	NP_115815	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting	179											0						GATTGCAGGACGCATGCTTAA	0.303													26	60					5.45727e-16	6.73196e-16	1	0	A	60998404	A	A	60998404	3	1	29	1	0	0	0	0	1	0	0	0	11922	536	19	3	581	3	PHYHIPL	10	60998404	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	439437	60998404	74536343	251	5785											
CCDC6	8030	broad.mit.edu	37	chr10	61566690	61566690	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgcacacacctttcgtcgtCcatttctaagctggactcac	9	12	6	14	2	2	0	1	0	1	0	5	1	3	1	2	1	2	2	2	1	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:61566690C>A	uc001jks.3	-	6	1630	c.994G>T	c.(994-996)GAC>TAC	p.D332Y		NM_005436	NP_005427	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	332	Potential.					cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton			ovary(3)|breast(1)	4				Kidney(211;0.0597)		CTTTCGTCGTCCATTTCTAAG	0.453													18	42					2.21704e-12	2.56045e-12	1	0	A	61566690	A	A	61566690	3	1	29	1	0	0	0	0	1	0	0	0	2843	855	30	2	446	2	CCDC6	10	61566690	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	568286	61566690	73968057	252	5786											
ADK	132	broad.mit.edu	37	chr10	76158270	76158270	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctgccaattgttataaaaAggaaaaacatcttgatctgg	15	12	8	6	0	2	1	0	1	2	0	2	2	2	2	1	2	3	2	1	2	7	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:76158270A>C	uc001jwi.2	+	6	560	c.488A>C	c.(487-489)AAG>ACG	p.K163T	ADK_uc010qlb.1_Missense_Mutation_p.K163T|ADK_uc001jwj.2_Missense_Mutation_p.K146T|ADK_uc010qlc.1_Missense_Mutation_p.K128T	NM_006721	NP_006712	P55263	ADK_HUMAN	adenosine kinase isoform b	163					purine base metabolic process|purine ribonucleoside salvage	cytosol	adenosine kinase activity|ATP binding|metal ion binding|phosphotransferase activity, alcohol group as acceptor			ovary(1)|skin(1)	2	Prostate(51;0.0112)|Ovarian(15;0.148)				Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Pegademase bovine(DB00061)|Ribavirin(DB00811)	TGTTATAAAAAGGAAAAACAT	0.318													13	26					0	0	0	0	C	76158270	C	C	76158270	3	2	29	1	0	0	0	0	1	0	0	0	320	72	3	5	528	5	ADK	10	76158270	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	14591580	76158270	59376477	253	5787											
KCNMA1	3778	broad.mit.edu	37	chr10	78669856	78669856	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaacattagtatcgttcacTagaaaaagcataaaataaga	20	10	6	5	1	1	3	1	1	0	2	2	3	1	3	0	0	2	3	0	0	9	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:78669856T>C	uc001jxn.2	-	25	3194	c.3017_splice	c.e25-1	p.V1006_splice	KCNMA1_uc001jxj.2_Splice_Site_p.V952_splice|KCNMA1_uc001jxk.1_Splice_Site_p.V624_splice|KCNMA1_uc009xrt.1_Splice_Site_p.V797_splice|KCNMA1_uc001jxl.1_Splice_Site_p.V631_splice|KCNMA1_uc001jxo.2_Splice_Site_p.V989_splice|KCNMA1_uc001jxm.2_Splice_Site_p.V948_splice|KCNMA1_uc001jxq.2_Splice_Site_p.V978_splice	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium						cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TATCGTTCACTAGAAAAAGCA	0.438													23	33					0	0	0	0	C	78669856	C	C	78669856	5	2	29	1	0	0	0	0	0	0	1	0	8112	1536	53	5	740	5	KCNMA1	10	78669856	Splice_Site	SNP	T	TCGA-BB-7862-01A-21D-2229-08	2511586	78669856	56864891	254	5788											
RGR	5995	broad.mit.edu	37	chr10	86012697	86012697	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcagctctgccccttcTgggttggggtcactacgact	4	11	13	13	1	3	0	1	0	2	0	3	1	3	0	2	4	3	3	2	4	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:86012697T>A	uc001kdc.1	+	4	481	c.443T>A	c.(442-444)CTG>CAG	p.L148Q	RGR_uc001kdd.1_Missense_Mutation_p.L152Q|RGR_uc001kde.1_Missense_Mutation_p.L148Q	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	148	Helical; Name=4; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						CTGCCCCTTCTGGGTTGGGGT	0.617													23	49					0	0	0	0	A	86012697	A	A	86012697	3	1	29	1	0	0	0	0	1	0	0	0	13356	1580	55	5	469	5	RGR	10	86012697	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	7342841	86012697	49522050	255	5789											
LIPJ	142910	broad.mit.edu	37	chr10	90366488	90366488	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcaactgcaatttggaatGgtaaaagtgacttgttggct	11	13	12	5	0	0	1	0	1	0	0	0	2	0	2	0	4	2	5	0	4	5	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:90366488G>T	uc001kff.2	+	11	1239	c.925G>T	c.(925-927)GGT>TGT	p.G309C		NM_001010939	NP_001010939	Q5W064	LIPJ_HUMAN	lipase, family member J	309					lipid catabolic process		hydrolase activity			ovary(1)	1		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		AATTTGGAATGGTAAAAGTGA	0.313													34	44					1.41504e-22	1.83484e-22	1	0	T	90366488	T	T	90366488	3	4	29	1	0	0	0	0	1	0	0	0	8868	1348	47	4	959	4	LIPJ	10	90366488	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4353791	90366488	45168259	256	5790											
GPR120	338557	broad.mit.edu	37	chr10	95326494	95326494	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaatgtcccctgaatgcgCgcgggcagcgggcgacgcgc	6	4	18	13	7	0	1	0	1	0	0	1	3	1	2	2	3	2	1	2	3	2	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:95326494C>T	uc010qnt.1	+	1	73	c.17C>T	c.(16-18)GCG>GTG	p.A6V	GPR120_uc010qnu.1_Missense_Mutation_p.A6V	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	G protein-coupled receptor 120	6	Extracellular (Potential).				negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding				0		Colorectal(252;0.122)				CCTGAATGCGCGCGGGCAGCG	0.697													6	10					0	0	0	0	T	95326494	T	T	95326494	3	4	29	1	0	0	0	0	1	0	0	0	6674	768	27	1	19	1	GPR120	10	95326494	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	4960006	95326494	40208253	257	5791											
CYP2C9	1559	broad.mit.edu	37	chr10	96708890	96708890	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caataatttttctcctatcaTtgattacttcccgggaactc	10	16	4	11	1	2	1	1	1	1	0	5	2	3	2	2	1	2	0	2	1	5	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:96708890T>C	uc001kka.3	+	5	693	c.668T>C	c.(667-669)ATT>ACT	p.I223T	CYP2C9_uc009xut.2_Missense_Mutation_p.I223T	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	223					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TCTCCTATCATTGATTACTTC	0.274													18	23					0	0	0	0	C	96708890	C	C	96708890	3	2	29	1	0	0	0	0	1	0	0	0	4185	1493	52	5	686	5	CYP2C9	10	96708890	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	1382396	96708890	38825857	258	5792											
BLNK	29760	broad.mit.edu	37	chr10	97987324	97987324	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattttcatagtcgctgtccTgcaagtgcagatgcagacac	10	11	10	10	1	1	2	1	0	0	2	3	3	2	2	1	0	3	4	1	0	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:97987324T>G	uc001kls.3	-	5	383	c.205_splice	c.e5-1	p.D69_splice	BLNK_uc001kme.3_Splice_Site|BLNK_uc001klt.3_Splice_Site|BLNK_uc009xvc.2_Intron|BLNK_uc001klu.3_Splice_Site|BLNK_uc001klv.3_Splice_Site_p.D69_splice|BLNK_uc001klw.3_Splice_Site|BLNK_uc001klx.3_Splice_Site_p.D69_splice|BLNK_uc001kly.3_Splice_Site_p.D69_splice|BLNK_uc001klz.3_Splice_Site|BLNK_uc001kma.3_Splice_Site_p.D69_splice|BLNK_uc001kmb.3_Splice_Site|BLNK_uc001kmc.3_Splice_Site|BLNK_uc001kmd.3_Splice_Site|BLNK_uc009xvd.2_Splice_Site	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1						B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		GTCGCTGTCCTGCAAGTGCAG	0.562													42	87					0	0	0	0	G	97987324	G	G	97987324	5	3	29	1	0	0	0	0	0	0	1	0	1450	1594	55	5	1219	5	BLNK	10	97987324	Splice_Site	SNP	T	TCGA-BB-7862-01A-21D-2229-08	1278434	97987324	37547423	259	5793											
CRTAC1	55118	broad.mit.edu	37	chr10	99664467	99664467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctcatttgcagatagaGgcggtgggggccattccagt	7	10	16	8	1	1	2	1	0	0	2	2	2	2	2	2	5	2	2	2	5	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:99664467G>A	uc001kou.1	-	7	1311	c.955C>T	c.(955-957)CTC>TTC	p.L319F	CRTAC1_uc001kov.2_Missense_Mutation_p.L308F|CRTAC1_uc001kot.1_Missense_Mutation_p.L109F	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	319	FG-GAP 3; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		TGCAGATAGAGGCGGTGGGGG	0.493													58	120					0	0	0	0	A	99664467	A	A	99664467	3	1	29	1	0	0	0	0	1	0	0	0	3911	1000	35	4	1066	4	CRTAC1	10	99664467	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1677143	99664467	35870280	260	5794											
HPS1	3257	broad.mit.edu	37	chr10	100189563	100189563	+	Frame_Shift_Del	DEL	C	-	-																															cacaccgtctctgcagagctCcccccagttgggcccgtgga																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:100189563delC	uc010qpf.1	-	9	1098	c.852delG	c.(850-852)GGGfs	p.G284fs	HPS1_uc001kpi.1_Frame_Shift_Del_p.G284fs|HPS1_uc001kpj.1_Intron|HPS1_uc001kpk.1_Intron|HPS1_uc009xwb.2_Intron|HPS1_uc010qph.1_Frame_Shift_Del_p.G284fs|HPS1_uc001kpl.2_Frame_Shift_Del_p.G284fs	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	284					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		CTGCAGAGCTCCCCCCAGTTG	0.692									Hermansky-Pudlak_syndrome				---	---	---								-	100189563	-	-	100189563	7	5	29	1	0	1	0	1	0	0	0	0	7378	842	30	0	1336	0	HPS1	10	100189563	Frame_Shift_Del	DEL	C	TCGA-BB-7862-01A-21D-2229-08	525096	100189563	35345184	261	5795											
SORCS1	114815	broad.mit.edu	37	chr10	108339127	108339127	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggatagagggacacgcacCttttaaacttgtagatgacg	12	10	12	7	2	0	3	0	1	0	2	0	5	0	5	1	2	1	2	1	2	4	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:108339127C>G	uc001kym.2	-	25	3379	c.3371G>C	c.(3370-3372)AGG>ACG	p.R1124T	SORCS1_uc001kyl.2_Missense_Mutation_p.R1124T|SORCS1_uc009xxs.2_Missense_Mutation_p.R1124T|SORCS1_uc001kyn.1_Missense_Mutation_p.R1124T|SORCS1_uc001kyo.2_Missense_Mutation_p.R1124T	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1124	Cytoplasmic (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GGACACGCACCTTTTAAACTT	0.532													23	48					0	0	0	0	G	108339127	G	G	108339127	3	3	29	1	0	0	0	0	1	0	0	0	14994	695	24	4	377	4	SORCS1	10	108339127	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	8149564	108339127	27195620	262	5796											
KCNK18	338567	broad.mit.edu	37	chr10	118969760	118969760	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgattgacatatacaaaaatGttatgctattctttgcaaaa	16	15	5	5	0	1	2	0	2	1	0	1	2	1	2	0	0	3	3	0	0	8	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:118969760G>A	uc010qsr.1	+	3	1105	c.1105G>A	c.(1105-1107)GTT>ATT	p.V369I		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	369	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		ATACAAAAATGTTATGCTATT	0.378													34	81					0	0	0	0	A	118969760	A	A	118969760	3	1	29	1	0	0	0	0	1	0	0	0	8104	1377	48	4	1115	4	KCNK18	10	118969760	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	10630633	118969760	16564987	263	5797											
NPS	594857	broad.mit.edu	37	chr10	129347783	129347783	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaatctcatcctagttctGtcgctgtccacaatgcatgt	8	14	6	13	1	3	0	2	0	2	0	7	0	5	0	2	0	1	3	2	0	3	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:129347783G>T	uc001ljx.1	+	2	59	c.39G>T	c.(37-39)CTG>CTT	p.L13L		NM_001030013	NP_001025184	P0C0P6	NPS_HUMAN	neuropeptide S precursor	13					neuropeptide signaling pathway	extracellular region					0						TCCTAGTTCTGTCGCTGTCCA	0.368													31	77					5.71845e-15	6.93602e-15	1	0	T	129347783	T	T	129347783	2	4	29	1	0	0	0	0	0	0	0	1	10653	1364	48	4		4	NPS	10	129347783	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	10378023	129347783	6186964	264	5798											
C10orf93	255352	broad.mit.edu	37	chr10	134750492	134750492	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatattaatatagaaagtgActgacaggctaatggaattt	16	12	9	4	0	0	3	0	2	0	1	0	4	0	4	0	2	0	2	0	2	7	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr10:134750492A>C	uc001llt.1	-	7	804	c.728T>G	c.(727-729)GTC>GGC	p.V243G		NM_173572	NP_775843	Q5SR76	CJ093_HUMAN	hypothetical protein LOC255352	243							binding			pancreas(1)	1		all_cancers(35;1.8e-07)|all_epithelial(44;6.22e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Colorectal(31;0.119)|Glioma(114;0.172)|Melanoma(40;0.175)		Epithelial(32;4.28e-05)|OV - Ovarian serous cystadenocarcinoma(35;4.31e-05)|all cancers(32;5.02e-05)		ATAGAAAGTGACTGACAGGCT	0.229													7	18					0	0	0	0	C	134750492	C	C	134750492	3	2	29	1	0	0	0	0	1	0	0	0	1631	275	10	5	501	5	C10orf93	10	134750492	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	5402709	134750492	784255	265	5799											
OR51M1	390059	broad.mit.edu	37	chr11	5410672	5410672	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcctcaattcatgctgctatCcaacattactcagtttagcc	10	14	4	13	0	3	0	3	0	0	0	5	0	5	0	3	0	5	3	3	0	5	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:5410672C>G	uc010qzc.1	+	1	44	c.44C>G	c.(43-45)TCC>TGC	p.S15C	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	15						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGCTGCTATCCAACATTACT	0.393													67	138					0	0	0	0	G	5410672	G	G	5410672	3	3	29	1	0	0	0	0	1	0	0	0	11157	855	30	2	46	2	OR51M1	11	5410672	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08		5410672	129595844	266	5800											
OR10A6	390093	broad.mit.edu	37	chr11	7949863	7949863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcggtcataagccattgctCccagaagaaaacattcagcc	14	8	7	12	1	2	2	2	0	0	2	4	2	3	2	3	1	4	1	3	1	4	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:7949863C>T	uc010rbh.1	-	1	347	c.347G>A	c.(346-348)GGA>GAA	p.G116E		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGCCATTGCTCCCAGAAGAAA	0.368													44	75					0	0	0	0	T	7949863	T	T	7949863	3	4	29	1	0	0	0	0	1	0	0	0	10948	855	30	2	600	2	OR10A6	11	7949863	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2539191	7949863	127056653	267	5801											
CALCB	797	broad.mit.edu	37	chr11	15098958	15098958	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accaatgtgggttccaaagcCtttggcaggcgccgcaggga	9	7	14	11	2	0	0	0	0	0	0	1	1	1	1	4	4	1	3	4	4	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:15098958C>A	uc001mlx.1	+	4	424	c.351C>A	c.(349-351)GCC>GCA	p.A117A	CALCB_uc009ygr.1_Silent_p.A117A	NM_000728	NP_000719	P10092	CALCB_HUMAN	calcitonin-related polypeptide, beta precursor	117					cellular calcium ion homeostasis|signal transduction|vasodilation	extracellular region|soluble fraction	neuropeptide hormone activity				0						GTTCCAAAGCCTTTGGCAGGC	0.557													9	25					5.16669e-11	5.8998e-11	1	0	A	15098958	A	A	15098958	2	1	29	1	0	0	0	0	0	0	0	1	2588	668	24	4		4	CALCB	11	15098958	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	7149095	15098958	119907558	268	5802											
CALCB	797	broad.mit.edu	37	chr11	15098970	15098970	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccaaagcctttggcaggcgCcgcagggaccttcaagcctg	8	7	12	14	2	1	0	1	0	0	0	2	1	2	1	5	3	2	2	5	3	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:15098970C>G	uc001mlx.1	+	4	436	c.363C>G	c.(361-363)CGC>CGG	p.R121R	CALCB_uc009ygr.1_Silent_p.R121R	NM_000728	NP_000719	P10092	CALCB_HUMAN	calcitonin-related polypeptide, beta precursor	121					cellular calcium ion homeostasis|signal transduction|vasodilation	extracellular region|soluble fraction	neuropeptide hormone activity				0						TTGGCAGGCGCCGCAGGGACC	0.547													7	27					0	0	0	0	G	15098970	G	G	15098970	2	3	29	1	0	0	0	0	0	0	0	1	2588	726	26	4		4	CALCB	11	15098970	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	12	15098970	119907546	269	5803											
C11orf46	120534	broad.mit.edu	37	chr11	30354491	30354491	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatttgctccagaaactggtAaaagagaaaaaagaaggctt	19	8	9	5	0	0	3	0	0	0	3	1	4	1	3	1	2	2	3	1	2	8	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:30354491A>T	uc001mso.1	+	3	669	c.505A>T	c.(505-507)AAA>TAA	p.K169*		NM_152316	NP_689529	Q8N8R7	CK046_HUMAN	hypothetical protein LOC120534	169											0						AGAAACTGGTAAAAGAGAAAA	0.388													16	24					0	0	0	0	T	30354491	T	T	30354491	4	4	29	1	0	0	0	0	0	1	0	0	1649	363	13	5	511	5	C11orf46	11	30354491	Nonsense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	15255521	30354491	104652025	270	5804											
RAG1	5896	broad.mit.edu	37	chr11	36595864	36595864	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccgatatccatgcttccCtactgacctggagagtccag	8	11	9	13	1	0	2	0	1	0	1	3	4	3	2	5	1	3	1	5	1	2	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:36595864C>T	uc001mwu.3	+	2	1134	c.1010C>T	c.(1009-1011)CCT>CTT	p.P337L	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	337					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				CCATGCTTCCCTACTGACCTG	0.493									Familial_Hemophagocytic_Lymphohistiocytosis				26	51					0	0	0	0	T	36595864	T	T	36595864	3	4	29	1	0	0	0	0	1	0	0	0	13068	681	24	4	1012	4	RAG1	11	36595864	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	6241373	36595864	98410652	271	5805											
RAG1	5896	broad.mit.edu	37	chr11	36597586	36597586	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcccagaatccctctgccAgtacagtttcaattcacagc	10	10	7	14	0	3	1	2	0	1	1	4	1	4	1	3	0	4	2	3	0	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:36597586A>T	uc001mwu.3	+	2	2856	c.2732A>T	c.(2731-2733)CAG>CTG	p.Q911L	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	911					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				TCCCTCTGCCAGTACAGTTTC	0.463									Familial_Hemophagocytic_Lymphohistiocytosis				21	50					0	0	0	0	T	36597586	T	T	36597586	3	4	29	1	0	0	0	0	1	0	0	0	13068	188	7	5	2734	5	RAG1	11	36597586	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	1722	36597586	98408930	272	5806											
LRRC4C	57689	broad.mit.edu	37	chr11	40136477	40136477	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catagtctctactgtgacggTtgaaaagtaagagaaaggag	15	9	12	5	1	1	3	0	2	1	1	2	5	1	4	0	2	1	2	0	2	6	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:40136477T>A	uc001mxa.1	-	2	3330	c.1366A>T	c.(1366-1368)ACC>TCC	p.T456S	LRRC4C_uc001mxc.1_Missense_Mutation_p.T452S|LRRC4C_uc001mxd.1_Missense_Mutation_p.T452S|LRRC4C_uc001mxb.1_Missense_Mutation_p.T452S	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	456					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				ACTGTGACGGTTGAAAAGTAA	0.488													30	60					0	0	0	0	A	40136477	A	A	40136477	3	1	29	1	0	0	0	0	1	0	0	0	9058	1725	60	5	560	5	LRRC4C	11	40136477	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	3538891	40136477	94870039	273	5807											
OR4C13	283092	broad.mit.edu	37	chr11	49974158	49974158	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccccatgtactttttcctgGcctatctctcctttattgat	5	18	4	14	0	1	1	0	1	1	0	4	1	3	1	5	1	1	1	5	1	3	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:49974158G>T	uc010rhz.1	+	1	184	c.184G>T	c.(184-186)GCC>TCC	p.A62S		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						CTTTTTCCTGGCCTATCTCTC	0.433													98	219					6.99195e-59	9.87443e-59	1	0	T	49974158	T	T	49974158	3	4	29	1	0	0	0	0	1	0	0	0	11101	1203	42	4	186	4	OR4C13	11	49974158	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	9837681	49974158	85032358	274	5808											
OR4C16	219428	broad.mit.edu	37	chr11	55340089	55340089	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcagatttttcttgccctGagtttgccattctgtggccc	4	17	9	11	0	3	2	1	1	2	1	3	2	3	2	3	1	2	2	3	1	0	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:55340089G>T	uc010rih.1	+	1	486	c.486G>T	c.(484-486)CTG>CTT	p.L162L		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TTCTTGCCCTGAGTTTGCCAT	0.468													34	84					1.59361e-14	1.91007e-14	1	0	T	55340089	T	T	55340089	2	4	29	1	0	0	0	0	0	0	0	1	11103	1277	45	2		2	OR4C16	11	55340089	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	5365931	55340089	79666427	275	5809											
OR5D14	219436	broad.mit.edu	37	chr11	55563356	55563356	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtacttcctgtcctgcactGctgtggtgacagagtctttc	6	14	10	11	0	1	2	0	1	1	1	4	2	3	2	2	1	3	3	2	1	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:55563356G>A	uc010rim.1	+	1	325	c.325G>A	c.(325-327)GCT>ACT	p.A109T		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				GTCCTGCACTGCTGTGGTGAC	0.488													16	25					0	0	0	0	A	55563356	A	A	55563356	3	1	29	1	0	0	0	0	1	0	0	0	11209	1319	46	4	327	4	OR5D14	11	55563356	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	223267	55563356	79443160	276	5810											
OR8J3	81168	broad.mit.edu	37	chr11	55904598	55904598	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgttgctgcagatataaaGactattgtttctggtatgta	10	18	9	4	0	1	2	0	0	1	2	1	2	1	2	0	1	2	6	0	1	6	9			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:55904598G>T	uc010riz.1	-	1	597	c.597C>A	c.(595-597)GTC>GTA	p.V199V		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					CAGATATAAAGACTATTGTTT	0.313													28	42					5.77227e-19	7.27995e-19	1	0	T	55904598	T	T	55904598	2	4	29	1	0	0	0	0	0	0	0	1	11296	929	33	2		2	OR8J3	11	55904598	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	341242	55904598	79101918	277	5811											
OR8J1	219477	broad.mit.edu	37	chr11	56128008	56128008	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaactacctcattctatGaatgtgccacccaactggga	14	9	7	11	0	2	2	1	1	1	1	2	3	2	3	3	1	4	0	3	1	6	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:56128008G>T	uc010rjh.1	+	1	286	c.286G>T	c.(286-288)GAA>TAA	p.E96*		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E96A(1)		ovary(2)	2	Esophageal squamous(21;0.00448)					CTCATTCTATGAATGTGCCAC	0.418													35	64					1.96642e-18	2.46776e-18	1	0	T	56128008	T	T	56128008	4	4	29	1	0	0	0	0	0	1	0	0	11295	1291	45	2	288	2	OR8J1	11	56128008	Nonsense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	223410	56128008	78878508	278	5812											
OR5A2	219981	broad.mit.edu	37	chr11	59190059	59190059	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttgcagattgcagcatacCggtcataggccatagctgcc	9	9	12	11	1	1	1	1	0	0	1	1	1	1	1	3	3	6	5	3	3	3	5	rs151222077	by1000genomes	TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:59190059C>A	uc010rkt.1	-	1	368	c.368G>T	c.(367-369)CGG>CTG	p.R123L		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCAGCATACCGGTCATAGGC	0.483													18	28					3.99206e-14	4.75111e-14	1	0	A	59190059	A	A	59190059	3	1	29	1	0	0	0	0	1	0	0	0	11194	652	23	3	608	3	OR5A2	11	59190059	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	3062051	59190059	75816457	279	5813											
MS4A8B	83661	broad.mit.edu	37	chr11	60482537	60482537	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgctgctggtcttctgccTcctggagtttggcatcgcat	3	14	12	12	2	2	0	0	0	2	0	4	1	3	1	2	3	3	5	2	3	0	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:60482537T>C	uc001npv.2	+	6	781	c.578T>C	c.(577-579)CTC>CCC	p.L193P		NM_031457	NP_113645	Q9BY19	M4A8B_HUMAN	membrane-spanning 4-domains, subfamily A, member	193	Helical; (Potential).					integral to membrane	receptor activity				0						GTCTTCTGCCTCCTGGAGTTT	0.408													61	91					0	0	0	0	C	60482537	C	C	60482537	3	2	29	1	0	0	0	0	1	0	0	0	9920	1551	54	5	596	5	MS4A8B	11	60482537	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	1292478	60482537	74523979	280	5814											
MS4A10	341116	broad.mit.edu	37	chr11	60557908	60557908	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggcagacaagtgcacccCagaacacgacccagcccaag	13	2	9	17	1	0	2	0	0	0	2	0	3	0	2	5	1	3	2	5	1	3	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:60557908C>A	uc001npz.1	+	2	196	c.100C>A	c.(100-102)CAG>AAG	p.Q34K		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	34	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2						AAGTGCACCCCAGAACACGAC	0.587													39	82					1.91658e-06	2.03286e-06	1	0	A	60557908	A	A	60557908	3	1	29	1	0	0	0	0	1	0	0	0	9908	595	21	4	102	4	MS4A10	11	60557908	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	75371	60557908	74448608	281	5815											
PGA3	643834	broad.mit.edu	37	chr11	60971081	60971081	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggtggcactctctgagtgCatcatgtacaagtgagtccg	8	11	12	10	1	2	2	1	2	1	0	4	2	3	2	1	2	2	3	1	2	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:60971081C>T	uc001nqx.2	+	1	98	c.45C>T	c.(43-45)TGC>TGT	p.C15C	PGA3_uc010rld.1_Silent_p.C15C	NM_001079807	NP_001073275			pepsinogen 3, group I precursor											ovary(1)|skin(1)	2						TCTCTGAGTGCATCATGTACA	0.567													67	50					0	0	0	0	T	60971081	T	T	60971081	2	4	29	1	0	0	0	0	0	0	0	1	11826	718	25	4		4	PGA3	11	60971081	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	413173	60971081	74035435	282	5816											
VWCE	220001	broad.mit.edu	37	chr11	61032011	61032011	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agggcagggtcggcacaggcCcgctggcagggaaccttctc	7	5	16	13	2	1	0	0	0	1	0	3	1	1	1	2	6	1	4	2	6	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:61032011C>A	uc001nra.2	-	19	2457	c.2178G>T	c.(2176-2178)CGG>CGT	p.R726R	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	726	VWFC 6.					extracellular region	calcium ion binding			ovary(1)	1						CGGCACAGGCCCGCTGGCAGG	0.617													7	14					1.58986e-06	1.68986e-06	1	0	A	61032011	A	A	61032011	2	1	29	1	0	0	0	0	0	0	0	1	17313	610	22	4		4	VWCE	11	61032011	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	60930	61032011	73974505	283	5817											
NDUFS8	4728	broad.mit.edu	37	chr11	67803773	67803773	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagccgccggaccacccgCtatgacatcgacatgaccaa	11	4	10	16	4	0	2	0	2	0	0	1	4	0	3	5	2	1	2	5	2	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:67803773C>T	uc001onc.2	+	6	533	c.426C>T	c.(424-426)CGC>CGT	p.R142R	NDUFS8_uc009ysb.1_RNA|NDUFS8_uc009ysc.1_Silent_p.R142R|TCIRG1_uc001ond.1_5'Flank|TCIRG1_uc001one.2_5'Flank	NM_002496	NP_002487	O00217	NDUS8_HUMAN	NADH dehydrogenase ubiquinone Fe-S 8 precursor	142	4Fe-4S ferredoxin-type 2.				mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)	GGACCACCCGCTATGACATCG	0.662													19	26					0	0	0	0	T	67803773	T	T	67803773	2	4	29	1	0	0	0	0	0	0	0	1	10352	784	28	4		4	NDUFS8	11	67803773	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	6771762	67803773	67202743	284	5818											
MYEOV	26579	broad.mit.edu	37	chr11	69063226	69063226	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggtttgctgctggagcTggtgaccgggagagaaacaa	9	9	16	7	1	0	2	0	1	0	1	0	5	0	4	1	4	4	4	1	4	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:69063226T>A	uc001oov.2	+	3	759	c.309T>A	c.(307-309)GCT>GCA	p.A103A	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Silent_p.A103A|MYEOV_uc001oow.2_Silent_p.A45A	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	103											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		CTGCTGGAGCTGGTGACCGGG	0.647													28	64					0	0	0	0	A	69063226	A	A	69063226	2	1	29	1	0	0	0	0	0	0	0	1	10078	1567	55	5		5	MYEOV	11	69063226	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	1259453	69063226	65943290	285	5819											
FOLR2	2350	broad.mit.edu	37	chr11	71932330	71932330	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cacacgtgcaagagcaactgGcacagaggatgggactggac	13	4	14	10	1	0	2	0	0	0	2	0	5	0	5	0	4	3	3	0	4	2	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:71932330G>A	uc009ytd.2	+	4	619	c.450G>A	c.(448-450)TGG>TGA	p.W150*	FOLR2_uc009yte.2_Nonsense_Mutation_p.W150*|FOLR2_uc001ose.3_Nonsense_Mutation_p.W150*|FOLR2_uc009ytf.2_Nonsense_Mutation_p.W150*	NM_001113534	NP_001107006	P14207	FOLR2_HUMAN	folate receptor 2 precursor	150					folic acid transport	anchored to membrane|extracellular region|membrane fraction|plasma membrane	folic acid binding|receptor activity			breast(2)|ovary(1)	3					Folic Acid(DB00158)	AGAGCAACTGGCACAGAGGAT	0.532													11	37					0	0	0	0	A	71932330	A	A	71932330	4	1	29	1	0	0	0	0	0	1	0	0	6014	1212	42	4	460	4	FOLR2	11	71932330	Nonsense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2869104	71932330	63074186	286	5820											
KLHL35	283212	broad.mit.edu	37	chr11	75139659	75139659	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgaccacgatcacttcagcTaggtccatgaatctggcgtg	10	10	10	11	2	3	2	2	2	1	0	4	3	4	2	2	2	1	1	2	2	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:75139659T>G	uc001owm.1	-	2	453	c.234A>C	c.(232-234)CTA>CTC	p.L78L		NM_001039548	NP_001034637	Q6PF15	KLH35_HUMAN	kelch-like 35	78											0						TCACTTCAGCTAGGTCCATGA	0.627													13	46					0	0	0	0	G	75139659	G	G	75139659	2	3	29	1	0	0	0	0	0	0	0	1	8427	1509	53	5		5	KLHL35	11	75139659	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	3207329	75139659	59866857	287	5821											
MOGAT2	80168	broad.mit.edu	37	chr11	75438505	75438505	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caagactgctgagctggaccCctctcggaactacattgcgg	9	8	11	13	2	1	2	0	1	1	1	2	4	1	4	2	3	5	2	2	3	3	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:75438505C>T	uc010rru.1	+	3	296	c.296C>T	c.(295-297)CCC>CTC	p.P99L	MOGAT2_uc001oww.1_Missense_Mutation_p.P99L|MOGAT2_uc010rrv.1_Missense_Mutation_p.P17L	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	99					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					GAGCTGGACCCCTCTCGGAAC	0.438													18	46					0	0	0	0	T	75438505	T	T	75438505	3	4	29	1	0	0	0	0	1	0	0	0	9748	623	22	4	306	4	MOGAT2	11	75438505	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	298846	75438505	59568011	288	5822											
ODZ4	26011	broad.mit.edu	37	chr11	78498058	78498058	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtcgcaggctgcccccatCcagccatcctcgcagcggca	6	6	11	18	3	0	0	0	0	0	0	4	0	2	0	5	3	3	4	5	3	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:78498058C>A	uc001ozl.3	-	16	2713	c.2250G>T	c.(2248-2250)TGG>TGT	p.W750C		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	750	Extracellular (Potential).|EGF-like 6.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CTGCCCCCATCCAGCCATCCT	0.692													8	7					0.00307968	0.00313534	1	0	A	78498058	A	A	78498058	3	1	29	1	0	0	0	0	1	0	0	0	10891	856	30	2	6135	2	ODZ4	11	78498058	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	3059553	78498058	56508458	289	5823											
CCDC89	220388	broad.mit.edu	37	chr11	85396955	85396955	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatgcagatgagctgggaCtgctcttcaatgcgggagcg	9	8	16	8	2	2	2	1	1	1	1	2	5	2	5	0	3	5	3	0	3	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:85396955C>A	uc001pau.1	-	1	366	c.219G>T	c.(217-219)CAG>CAT	p.Q73H		NM_152723	NP_689936	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	73	Potential.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TGAGCTGGGACTGCTCTTCAA	0.587													17	30					9.16793e-09	1.00827e-08	1	0	A	85396955	A	A	85396955	3	1	29	1	0	0	0	0	1	0	0	0	2879	564	20	4	909	4	CCDC89	11	85396955	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	6898897	85396955	49609561	290	5824											
FAT3	120114	broad.mit.edu	37	chr11	92570929	92570929	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatttctgatgtgaatgacaAcagcccggtgtttacacctg	10	13	9	9	1	1	3	0	3	1	0	1	3	1	3	2	1	3	1	2	1	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:92570929A>G	uc001pdj.3	+	16	10342	c.10325A>G	c.(10324-10326)AAC>AGC	p.N3442S	FAT3_uc001pdi.3_5'Flank	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3442	Extracellular (Potential).|Cadherin 31.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGAATGACAACAGCCCGGTG	0.468										TCGA Ovarian(4;0.039)			18	57					0	0	0	0	G	92570929	G	G	92570929	3	3	29	1	0	0	0	0	1	0	0	0	5723	43	2	5	10387	5	FAT3	11	92570929	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	7173974	92570929	42435587	291	5825											
CASP5	838	broad.mit.edu	37	chr11	104869611	104869611	+	Splice_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgttactaaaagacacataCgtggtgttgaagaacagaaa	17	9	9	6	1	0	4	0	1	0	3	0	4	0	4	0	1	3	2	0	1	7	4	rs141481245	byFrequency	TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:104869611C>T	uc010rva.1	-	7	1128	c.1096_splice	c.e7+1	p.H366_splice	CASP5_uc010ruz.1_Splice_Site_p.H379_splice|CASP5_uc010rvb.1_Splice_Site_p.H308_splice|CASP5_uc010rvc.1_Splice_Site_p.H224_splice|CASP5_uc009yxh.2_Splice_Site_p.H148_splice|CASP5_uc010rvd.1_Splice_Site_p.H148_splice	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor						apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		AAGACACATACGTGGTGTTGA	0.438													33	57					0	0	0	0	T	104869611	T	T	104869611	5	4	29	1	0	0	0	0	0	0	1	0	2686	550	19	1	219	1	CASP5	11	104869611	Splice_Site	SNP	C	TCGA-BB-7862-01A-21D-2229-08	12298682	104869611	30136905	292	5826											
CWF19L2	143884	broad.mit.edu	37	chr11	107200714	107200714	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accctccgtgaaggccaaaaTccacagagaagtaaggtaac	16	5	9	11	1	0	2	0	1	0	1	2	3	2	2	4	2	1	2	4	2	6	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:107200714T>C	uc010rvp.1	-	17	2501	c.2471A>G	c.(2470-2472)GAT>GGT	p.D824G	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	824							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		AAGGCCAAAATCCACAGAGAA	0.398													4	9					0	0	0	0	C	107200714	C	C	107200714	3	2	29	1	0	0	0	0	1	0	0	0	4089	1435	50	5	221	5	CWF19L2	11	107200714	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	2331103	107200714	27805802	293	5827											
DSCAML1	57453	broad.mit.edu	37	chr11	117403130	117403130	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccattgctctgccgggtctCcccgctatacttgtgcttgg	3	13	10	15	2	2	0	0	0	2	0	3	0	2	0	4	2	4	3	4	2	2	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:117403130C>A	uc001prh.1	-	4	801	c.799G>T	c.(799-801)GAG>TAG	p.E267*	DSCAML1_uc001pri.1_Nonsense_Mutation_p.E71*	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	207	Extracellular (Potential).|Ig-like C2-type 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGCCGGGTCTCCCCGCTATAC	0.607													38	79					1.30475e-32	1.76874e-32	1	0	A	117403130	A	A	117403130	4	1	29	1	0	0	0	0	0	1	0	0	4791	864	30	2	5662	2	DSCAML1	11	117403130	Nonsense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	10202416	117403130	17603386	294	5828											
PHLDB1	23187	broad.mit.edu	37	chr11	118513088	118513088	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctcccccgcctctgccCgccaaagcttcccgtcagct	4	10	6	21	3	4	0	1	0	3	0	6	0	5	0	6	0	3	2	6	0	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:118513088C>T	uc001ptr.1	+	14	3206	c.2853C>T	c.(2851-2853)CCC>CCT	p.P951P	PHLDB1_uc001pts.2_Silent_p.P951P|PHLDB1_uc001ptt.2_Intron|PHLDB1_uc001ptu.1_RNA|PHLDB1_uc001ptv.1_Silent_p.P751P|PHLDB1_uc001ptw.1_Intron|PHLDB1_uc009zai.1_Intron|PHLDB1_uc001ptx.1_Intron|PHLDB1_uc010ryi.1_Silent_p.P94P|PHLDB1_uc010ryj.1_Silent_p.P89P	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	951											0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CGCCTCTGCCCGCCAAAGCTT	0.637													58	156					0	0	0	0	T	118513088	T	T	118513088	2	4	29	1	0	0	0	0	0	0	0	1	11906	639	23	1		1	PHLDB1	11	118513088	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1109958	118513088	16493428	295	5829											
TMEM225	338661	broad.mit.edu	37	chr11	123754038	123754038	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctactggtagacaacttgCactctaggagagagaggact	13	8	12	8	0	1	3	0	0	1	3	1	6	1	4	0	3	4	3	0	3	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:123754038C>T	uc001pzi.2	-	4	693	c.485G>A	c.(484-486)TGC>TAC	p.C162Y		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	162						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						AGACAACTTGCACTCTAGGAG	0.428													17	35					0	0	0	0	T	123754038	T	T	123754038	3	4	29	1	0	0	0	0	1	0	0	0	16213	710	25	4	196	4	TMEM225	11	123754038	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	5240950	123754038	11252478	296	5830											
TMEM225	338661	broad.mit.edu	37	chr11	123756046	123756046	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattcaacccatttatctaaGgtgattcccatcaccattaa	14	13	3	11	0	3	1	2	1	1	0	4	1	4	1	3	1	1	0	3	1	5	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:123756046G>A	uc001pzi.2	-	1	295	c.87C>T	c.(85-87)ACC>ACT	p.T29T		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	29	Helical; (Potential).					integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						ATTTATCTAAGGTGATTCCCA	0.423													27	45					0	0	0	0	A	123756046	A	A	123756046	2	1	29	1	0	0	0	0	0	0	0	1	16213	987	35	4		4	TMEM225	11	123756046	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2008	123756046	11250470	297	5831											
OR10G9	219870	broad.mit.edu	37	chr11	123893799	123893799	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gctggacgccccactctttgGaatcttcctggtggtttacg	5	13	11	12	2	2	0	0	0	2	0	3	2	3	2	3	4	1	2	3	4	2	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:123893799G>C	uc010sad.1	+	1	80	c.80G>C	c.(79-81)GGA>GCA	p.G27A		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCACTCTTTGGAATCTTCCTG	0.572													70	228					0	0	0	0	C	123893799	C	C	123893799	3	2	29	1	0	0	0	0	1	0	0	0	10958	1174	41	2	82	2	OR10G9	11	123893799	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	137753	123893799	11112717	298	5832											
VWA5A	4013	broad.mit.edu	37	chr11	123988981	123988981	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctccagggatgtcttctCttgcaatgtgggtaacctcc	7	12	10	12	0	2	0	0	0	2	0	5	1	4	1	3	2	3	3	3	2	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:123988981C>G	uc001pzu.2	+	5	541	c.332C>G	c.(331-333)TCT>TGT	p.S111C	VWA5A_uc001pzr.2_Missense_Mutation_p.S111C|VWA5A_uc001pzs.2_Missense_Mutation_p.S111C|VWA5A_uc010sae.1_Missense_Mutation_p.S127C|VWA5A_uc001pzt.2_Missense_Mutation_p.S111C	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	111	VIT.									upper_aerodigestive_tract(1)|ovary(1)	2						GATGTCTTCTCTTGCAATGTG	0.587													46	95					0	0	0	0	G	123988981	G	G	123988981	3	3	29	1	0	0	0	0	1	0	0	0	17310	913	32	2	342	2	VWA5A	11	123988981	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	95182	123988981	11017535	299	5833											
CDON	50937	broad.mit.edu	37	chr11	125887193	125887193	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actcaccacacactccaaggTtacagggctacgagaaagaa	16	5	8	12	1	1	2	1	0	0	2	2	3	2	2	2	2	2	2	2	2	5	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr11:125887193T>A	uc009zbw.2	-	6	846	c.718A>T	c.(718-720)ACC>TCC	p.T240S	CDON_uc001qdc.3_Missense_Mutation_p.T240S|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.T240S	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	240	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CACTCCAAGGTTACAGGGCTA	0.502													27	39					0	0	0	0	A	125887193	A	A	125887193	3	1	29	1	0	0	0	0	1	0	0	0	3185	1725	60	5	3136	5	CDON	11	125887193	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	1898212	125887193	9119323	300	5834											
WNK1	65125	broad.mit.edu	37	chr12	1005419	1005420	+	Frame_Shift_Del	DEL	AG	-	-																															ggtatctcttcagatgtgccAgagagtgcccacaaaactac																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:1005419_1005420delAG	uc001qio.3	+	24	6273_6274	c.5766_5767delAG	c.(5764-5769)CCAGAGfs	p.P1922fs	WNK1_uc001qip.3_Frame_Shift_Del_p.P1674fs|WNK1_uc001qir.3_Frame_Shift_Del_p.P1095fs	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1922_1923					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CAGATGTGCCAGAGAGTGCCCA	0.505													---	---	---								-	1005420	-	-	1005419	7	5	29	1	0	1	0	1	0	0	0	0	17445	175	7	0	7362	0	WNK1	12	1005419	Frame_Shift_Del	DEL	AG	TCGA-BB-7862-01A-21D-2229-08		1005419	132846476	301	5835											
EMG1	10436	broad.mit.edu	37	chr12	7080212	7080213	+	Splice_Site	INS	-	C	C																															acaagatcggaggccgtagtINSttattgtggtgctggaaggg																								rs17857448		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:7080212_7080213insC	uc001qsh.3	+	2	272	c.129_splice	c.e2+1	p.L43_splice	PHB2_uc001qsd.2_5'Flank|PHB2_uc010sft.1_5'Flank|PHB2_uc010sfu.1_5'Flank|EMG1_uc009zfo.2_RNA|EMG1_uc010sfv.1_RNA	NM_006331	NP_006322	Q92979	NEP1_HUMAN	ribosome biogenesis protein NEP1						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding				0						GAGGCCGTAGTTTATTGTGGTG	0.569													---	---	---								C	7080213	C	C	7080212	8	5	29	1	0	1	1	0	0	0	1	0	5114	1722	60	0	128	0	EMG1	12	7080212	Splice_Site	INS	-	TCGA-BB-7862-01A-21D-2229-08	6074793	7080212	126771683	302	5836											
C1R	715	broad.mit.edu	37	chr12	7242032	7242032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggtaggaccgagggtactCcaggctggagatgtagcctg	8	7	18	8	1	0	1	0	0	0	1	1	4	1	2	3	6	2	4	3	6	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:7242032C>T	uc010sfy.1	-	5	684	c.625G>A	c.(625-627)GAG>AAG	p.E209K	C1R_uc010sfz.1_Missense_Mutation_p.E223K|C1R_uc010sga.1_Missense_Mutation_p.E175K	NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	209	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CGAGGGTACTCCAGGCTGGAG	0.622													26	25					0	0	0	0	T	7242032	T	T	7242032	3	4	29	1	0	0	0	0	1	0	0	0	1981	864	30	2	1199	2	C1R	12	7242032	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	161820	7242032	126609863	303	5837											
CLEC4C	170482	broad.mit.edu	37	chr12	7883448	7883448	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccaatgtcgccgaccccCtggatctgacagccccagaa	9	7	9	16	2	1	2	0	1	1	1	2	4	1	3	6	1	2	0	6	1	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:7883448C>A	uc001qtg.1	-	5	616	c.442G>T	c.(442-444)GGG>TGG	p.G148W	CLEC4C_uc001qth.1_Missense_Mutation_p.G148W|CLEC4C_uc001qti.1_Missense_Mutation_p.G117W	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	148	Extracellular (Potential).|C-type lectin.				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		CGCCGACCCCCTGGATCTGAC	0.413													115	86					6.25423e-57	8.80804e-57	1	0	A	7883448	A	A	7883448	3	1	29	1	0	0	0	0	1	0	0	0	3528	681	24	4	207	4	CLEC4C	12	7883448	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	641416	7883448	125968447	304	5838											
PRB4	5545	broad.mit.edu	37	chr12	11461215	11461215	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcaggtctgggtggcctGcccccttgaggaggtggagg	4	8	20	9	0	1	1	0	1	1	0	1	3	1	3	3	8	1	1	3	8	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:11461215G>C	uc001qzf.1	-	3	736	c.702C>G	c.(700-702)GGC>GGG	p.G234G	PRB4_uc001qzt.2_Silent_p.G234G	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	297						extracellular region				ovary(1)	1						TGGGTGGCCTGCCCCCTTGAG	0.577										HNSCC(22;0.051)			57	235					0	0	0	0	C	11461215	C	C	11461215	2	2	29	1	0	0	0	0	0	0	0	1	12507	1306	46	4		4	PRB4	12	11461215	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	3577767	11461215	122390680	305	5839											
PRB1	5542	broad.mit.edu	37	chr12	11506214	11506214	+	Frame_Shift_Del	DEL	G	-	-																															tggctttcctggaggagatcGggcactttgggacttgctgc																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:11506214delG	uc001qzw.1	-	4	860	c.823delC	c.(823-825)CGAfs	p.R275fs	PRB1_uc001qzu.1_Frame_Shift_Del_p.R142fs|PRB1_uc001qzv.1_Frame_Shift_Del_p.R122fs	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	336	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].|14.					extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGAGGAGATCGGGCACTTTGG	0.607													---	---	---								-	11506214	-	-	11506214	7	5	29	1	0	1	0	1	0	0	0	0	12504	1124	39	0	176	0	PRB1	12	11506214	Frame_Shift_Del	DEL	G	TCGA-BB-7862-01A-21D-2229-08	44999	11506214	122345681	306	5840											
LST-3TM12	338821	broad.mit.edu	37	chr12	21205184	21205184	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcaaatcttcaagtggtaatAaagagcccatagtgagtatt	15	11	9	6	0	2	2	1	1	1	1	2	2	2	2	1	1	1	3	1	1	7	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:21205184A>G	uc010sin.1	+	9	1345	c.1345A>G	c.(1345-1347)AAA>GAA	p.K449E	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Missense_Mutation_p.K496E	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	449						membrane	transporter activity				0						AAGTGGTAATAAAGAGCCCAT	0.353													100	73					0	0	0	0	G	21205184	G	G	21205184	3	3	29	1	0	0	0	0	1	0	0	0	9116	363	13	5	1379	5	LST-3TM12	12	21205184	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	9698970	21205184	112646711	307	5841											
MLL2	8085	broad.mit.edu	37	chr12	49421894	49421894	+	Frame_Shift_Del	DEL	C	-	-																															gatcttcatgctcagcagctCcgccactgccaccatcacgc																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:49421894delC	uc001rta.3	-	46	14413	c.14413delG	c.(14413-14415)GAGfs	p.E4805fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4805					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTCAGCAGCTCCGCCACTGCC	0.592			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								-	49421894	-	-	49421894	7	5	29	1	0	1	0	1	0	0	0	0	9674	864	30	0	2236	0	MLL2	12	49421894	Frame_Shift_Del	DEL	C	TCGA-BB-7862-01A-21D-2229-08	28216710	49421894	84430001	308	5842											
AQP2	359	broad.mit.edu	37	chr12	50344932	50344932	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccgctctgctccatgagAtcacgccagcagacatccgc	9	6	10	16	3	2	2	1	1	1	2	4	4	4	2	4	0	3	3	4	0	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:50344932A>G	uc001rvn.2	+	1	409	c.319A>G	c.(319-321)ATC>GTC	p.I107V		NM_000486	NP_000477	P41181	AQP2_HUMAN	aquaporin 2	107	Helical; (Potential).				cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			ovary(2)	2						GCTCCATGAGATCACGCCAGC	0.642													14	23					0	0	0	0	G	50344932	G	G	50344932	3	3	29	1	0	0	0	0	1	0	0	0	826	333	12	5	321	5	AQP2	12	50344932	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	923038	50344932	83506963	309	5843											
SCN8A	6334	broad.mit.edu	37	chr12	52159508	52159508	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accctgaacatgctaatcaaGattattggaaattcagtggg	14	11	9	7	0	2	2	2	1	0	1	2	3	2	3	1	2	2	1	1	2	5	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:52159508G>A	uc001ryw.2	+	16	2776	c.2598G>A	c.(2596-2598)AAG>AAA	p.K866K	SCN8A_uc010snl.1_Silent_p.K731K|SCN8A_uc001ryy.2_Silent_p.K731K	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	866	II.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TGCTAATCAAGATTATTGGAA	0.428													21	20					0	0	0	0	A	52159508	A	A	52159508	2	1	29	1	0	0	0	0	0	0	0	1	13989	933	33	2		2	SCN8A	12	52159508	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1814576	52159508	81692387	310	5844											
KRT80	144501	broad.mit.edu	37	chr12	52566834	52566835	+	Frame_Shift_Del	DEL	AG	-	-																															atactcacatggctcttgacAgagaggatctgggaccgcag																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:52566834_52566835delAG	uc001rzx.2	-	6	1042_1043	c.944_945delCT	c.(943-945)TCTfs	p.S315fs	KRT80_uc001rzw.2_Frame_Shift_Del_p.S350fs|KRT80_uc001rzy.2_Frame_Shift_Del_p.S315fs	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	315	Rod.|Coil 2.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)		GGCTCTTGACAGAGAGGATCTG	0.609													---	---	---								-	52566835	-	-	52566834	7	5	29	1	0	1	0	1	0	0	0	0	8533	175	7	0	464	0	KRT80	12	52566834	Frame_Shift_Del	DEL	AG	TCGA-BB-7862-01A-21D-2229-08	407326	52566834	81285061	311	5845											
HOXC9	3225	broad.mit.edu	37	chr12	54396287	54396287	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccctacaccaagtaccagacGctggaactggagaaggagtt	13	6	11	11	1	0	2	0	0	0	2	0	5	0	4	3	3	3	3	3	3	5	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:54396287G>A	uc001sep.2	+	3	710	c.612G>A	c.(610-612)ACG>ACA	p.T204T	HOXC9_uc001seq.2_Silent_p.T204T	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	204	Homeobox.				multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						AGTACCAGACGCTGGAACTGG	0.572													37	72					0	0	0	0	A	54396287	A	A	54396287	2	1	29	1	0	0	0	0	0	0	0	1	7356	1074	38	1		1	HOXC9	12	54396287	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1829453	54396287	79455608	312	5846											
KIAA0748	9840	broad.mit.edu	37	chr12	55367305	55367305	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttattgattggattcccTagaaaagtcagacactagat	14	14	7	6	0	1	4	1	1	0	3	2	5	2	5	1	1	0	0	1	1	5	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:55367305T>C	uc001sgn.3	-	3	274	c.164_splice	c.e3-1	p.G55_splice	KIAA0748_uc001sgl.3_5'UTR|KIAA0748_uc001sgm.3_5'UTR|KIAA0748_uc010spb.1_5'UTR|KIAA0748_uc010spc.1_Splice_Site|KIAA0748_uc010spd.1_Splice_Site_p.G55_splice|KIAA0748_uc001sgo.3_Splice_Site	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840											ovary(1)|central_nervous_system(1)	2						TTGGATTCCCTAGAAAAGTCA	0.438													27	59					0	0	0	0	C	55367305	C	C	55367305	5	2	29	1	0	0	0	0	0	0	1	0	8229	1536	53	5	1435	5	KIAA0748	12	55367305	Splice_Site	SNP	T	TCGA-BB-7862-01A-21D-2229-08	971018	55367305	78484590	313	5847											
ESYT1	23344	broad.mit.edu	37	chr12	56522379	56522379	+	Frame_Shift_Del	DEL	C	-	-																															gccctctacctgggctggcgCcgggtccgcgacgagaaaga																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:56522379delC	uc001sjq.2	+	1	326	c.276delC	c.(274-276)CGCfs	p.R92fs	ESYT1_uc001sjr.2_Frame_Shift_Del_p.R92fs	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	92	Potential.					integral to membrane				ovary(4)|skin(1)	5						TGGGCTGGCGCCGGGTCCGCG	0.617													---	---	---								-	56522379	-	-	56522379	7	5	29	1	0	1	0	1	0	0	0	0	5288	726	26	0	278	0	ESYT1	12	56522379	Frame_Shift_Del	DEL	C	TCGA-BB-7862-01A-21D-2229-08	1155074	56522379	77329516	314	5848											
ARHGAP9	64333	broad.mit.edu	37	chr12	57870384	57870384	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggttctcacctgagcttgcgCcccccttgggcaatcttggt	4	12	11	14	1	2	1	1	1	2	0	3	1	2	1	4	3	2	3	4	3	1	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:57870384C>T	uc001sod.2	-	10	1420	c.1227G>A	c.(1225-1227)GGG>GGA	p.G409G	ARHGAP9_uc001sny.2_5'Flank|ARHGAP9_uc001snz.2_Silent_p.G154G|ARHGAP9_uc001soa.2_Silent_p.G8G|ARHGAP9_uc001sob.2_Silent_p.G338G|ARHGAP9_uc001soc.2_Silent_p.G338G|ARHGAP9_uc001soe.1_Silent_p.G417G	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	338	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			TGAGCTTGCGCCCCCCTTGGG	0.562													70	150					0	0	0	0	T	57870384	T	T	57870384	2	4	29	1	0	0	0	0	0	0	0	1	889	726	26	4		4	ARHGAP9	12	57870384	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1348005	57870384	75981511	315	5849											
GALNT4	8693	broad.mit.edu	37	chr12	89919631	89919632	+	5'Flank	DEL	CC	-	-																															ggacaggctccagggagggaCcccccccacctccaacccgt																								rs67346689		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:89919631_89919632delCC	uc001tbd.2	-						POC1B_uc001tba.2_5'Flank|POC1B_uc001tbb.2_5'Flank|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Intron|GALNT4_uc010suo.1_Intron	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4						carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						CAGGGAGGGACCCCCCCCACCT	0.668													---	---	---								-	89919632	-	-	89919631	6	5	29	0	1	1	0	1	0	0	0	0	6250	522	18	0		0	GALNT4	12	89919631	5'Flank	DEL	CC	TCGA-BB-7862-01A-21D-2229-08	32049247	89919631	43932264	316	5850											
C12orf63	374467	broad.mit.edu	37	chr12	97147651	97147651	+	Frame_Shift_Del	DEL	G	-	-																															gcagtggaggaacatgaggtGgaagctgaaatcctttttca																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:97147651delG	uc001tet.1	+	23	3168	c.3090delG	c.(3088-3090)GTGfs	p.V1030fs		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1030										skin(6)|ovary(1)	7						AACATGAGGTGGAAGCTGAAA	0.403													---	---	---								-	97147651	-	-	97147651	7	5	29	1	0	1	0	1	0	0	0	0	1712	1335	47	0	3176	0	C12orf63	12	97147651	Frame_Shift_Del	DEL	G	TCGA-BB-7862-01A-21D-2229-08	7228020	97147651	36704244	317	5851											
DNAH10	196385	broad.mit.edu	37	chr12	124289536	124289536	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccccaagctggcctcctactAcaaatactgggaaaagaaaa	16	6	7	12	0	0	1	0	0	0	1	1	2	1	2	4	2	4	1	4	2	9	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:124289536A>G	uc001uft.3	+	17	2607	c.2582A>G	c.(2581-2583)TAC>TGC	p.Y861C	DNAH10_uc010tav.1_Missense_Mutation_p.Y403C|DNAH10_uc010taw.1_Missense_Mutation_p.Y346C	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	861	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCCTCCTACTACAAATACTGG	0.468													24	47					0	0	0	0	G	124289536	G	G	124289536	3	3	29	1	0	0	0	0	1	0	0	0	4620	391	14	5	2648	5	DNAH10	12	124289536	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	27141885	124289536	9562359	318	5852											
NCOR2	9612	broad.mit.edu	37	chr12	124846798	124846798	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgggggagctggcttggTgggagctgcgtcctcccggg	2	8	21	10	2	0	0	0	0	0	0	2	2	2	2	2	7	3	4	2	7	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:124846798T>A	uc010tba.1	-	22	3091	c.2974A>T	c.(2974-2976)ACC>TCC	p.T992S	NCOR2_uc010tay.1_Missense_Mutation_p.T991S|NCOR2_uc010taz.1_Missense_Mutation_p.T975S|NCOR2_uc010tbb.1_Missense_Mutation_p.T992S|NCOR2_uc010tbc.1_Missense_Mutation_p.T974S|NCOR2_uc001ugj.1_Missense_Mutation_p.T992S	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	992					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCTGGCTTGGTGGGAGCTGCG	0.667													13	21					0	0	0	0	A	124846798	A	A	124846798	3	1	29	1	0	0	0	0	1	0	0	0	10290	1696	59	5	4698	5	NCOR2	12	124846798	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	557262	124846798	9005097	319	5853											
ULK1	8408	broad.mit.edu	37	chr12	132396562	132396562	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcttcctgcacagctccCgggactctggtggcagcaag	6	8	13	14	1	1	0	0	0	1	0	3	1	3	1	2	4	3	5	2	4	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr12:132396562C>T	uc001uje.2	+	13	1292	c.1024C>T	c.(1024-1026)CGG>TGG	p.R342W		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	342	Interaction with GABARAP and GABARAPL2.				autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		GCACAGCTCCCGGGACTCTGG	0.652													19	30					0	0	0	0	T	132396562	T	T	132396562	3	4	29	1	0	0	0	0	1	0	0	0	17043	643	23	1	1074	1	ULK1	12	132396562	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	7549764	132396562	1455333	320	5854											
MTMR6	9107	broad.mit.edu	37	chr13	25825793	25825793	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcagaatacttacagattcTaggtctttaatatctttctc	11	18	4	8	0	5	2	1	0	4	2	6	2	5	2	0	1	2	0	0	1	6	9			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr13:25825793T>C	uc001uqf.3	-	13	1918	c.1599A>G	c.(1597-1599)CTA>CTG	p.L533L	MTMR6_uc001uqe.1_Silent_p.L533L	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	533						cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		TTACAGATTCTAGGTCTTTAA	0.274													5	3					0	0	0	0	C	25825793	C	C	25825793	2	2	29	1	0	0	0	0	0	0	0	1	10000	1509	53	5		5	MTMR6	13	25825793	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08		25825793	89344085	321	5855											
MTMR6	9107	broad.mit.edu	37	chr13	25840354	25840354	+	Frame_Shift_Del	DEL	C	-	-																															tcagcgagatcaatgagctgCcagccttgtagtcgttctga																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr13:25840354delC	uc001uqf.3	-	4	694	c.375delG	c.(373-375)TGGfs	p.W125fs	MTMR6_uc001uqe.1_Frame_Shift_Del_p.W125fs	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	125	Myotubularin phosphatase.			W -> R (in Ref. 4; CAD89918).		cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		CAATGAGCTGCCAGCCTTGTA	0.393													---	---	---								-	25840354	-	-	25840354	7	5	29	1	0	1	0	1	0	0	0	0	10000	740	26	0	1534	0	MTMR6	13	25840354	Frame_Shift_Del	DEL	C	TCGA-BB-7862-01A-21D-2229-08	14561	25840354	89329524	322	5856											
TRPC4	7223	broad.mit.edu	37	chr13	38320428	38320428	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccacatctgaactggacacGcattccacacagttacagcg	12	8	7	14	2	1	1	0	1	1	0	3	2	3	2	2	1	3	2	2	1	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr13:38320428G>T	uc001uws.2	-	3	778	c.543C>A	c.(541-543)TGC>TGA	p.C181*	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Nonsense_Mutation_p.C181*|TRPC4_uc010tey.1_Nonsense_Mutation_p.C181*|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Nonsense_Mutation_p.C181*|TRPC4_uc010aby.2_Nonsense_Mutation_p.C181*	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	181	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AACTGGACACGCATTCCACAC	0.507													36	19					6.97489e-18	8.71002e-18	1	0	T	38320428	T	T	38320428	4	4	29	1	0	0	0	0	0	1	0	0	16647	1079	38	3	2441	3	TRPC4	13	38320428	Nonsense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	12480074	38320428	76849450	323	5857											
TRPC4	7223	broad.mit.edu	37	chr13	38357115	38357115	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtttttctccactaggttttTtgtggttcaataacagctca	8	18	7	8	0	3	0	2	0	1	0	4	0	3	0	1	2	2	4	1	2	3	8			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr13:38357115T>C	uc001uws.2	-	2	591	c.356A>G	c.(355-357)AAA>AGA	p.K119R	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.K119R|TRPC4_uc010tey.1_Missense_Mutation_p.K119R|TRPC4_uc010abw.2_Missense_Mutation_p.K119R|TRPC4_uc010abx.2_Missense_Mutation_p.K119R|TRPC4_uc010aby.2_Missense_Mutation_p.K119R	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	119	ANK 3.|Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ACTAGGTTTTTTGTGGTTCAA	0.299													26	18					0	0	0	0	C	38357115	C	C	38357115	3	2	29	1	0	0	0	0	1	0	0	0	16647	1841	64	5	2632	5	TRPC4	13	38357115	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	36687	38357115	76812763	324	5858											
AKAP11	11215	broad.mit.edu	37	chr13	42891737	42891737	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcacggtagacccccagctAaggattattcttcagtggct	9	11	10	11	1	2	1	1	0	1	1	2	2	2	2	2	3	2	4	2	3	3	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr13:42891737A>G	uc001uys.1	+	12	5653	c.5478A>G	c.(5476-5478)CTA>CTG	p.L1826L		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1826					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		ACCCCCAGCTAAGGATTATTC	0.393													32	28					0	0	0	0	G	42891737	G	G	42891737	2	3	29	1	0	0	0	0	0	0	0	1	447	349	13	5		5	AKAP11	13	42891737	Silent	SNP	A	TCGA-BB-7862-01A-21D-2229-08	4534622	42891737	72278141	325	5859											
ZC3H13	23091	broad.mit.edu	37	chr13	46594641	46594641	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actttctggagttctttcctTagtgatttttatgtcttcct	5	22	6	8	0	3	1	0	1	3	0	5	2	5	2	2	1	0	1	2	1	2	8			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr13:46594641T>C	uc010tfw.1	-	4	397	c.391A>G	c.(391-393)AAG>GAG	p.K131E	ZC3H13_uc001vas.1_Missense_Mutation_p.K131E|ZC3H13_uc001vat.1_Missense_Mutation_p.K131E	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	131							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		GTTCTTTCCTTAGTGATTTTT	0.299													16	13					0	0	0	0	C	46594641	C	C	46594641	3	2	29	1	0	0	0	0	1	0	0	0	17632	1763	61	5	4355	5	ZC3H13	13	46594641	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	3702904	46594641	68575237	326	5860											
EFNB2	1948	broad.mit.edu	37	chr13	107145598	107145598	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgctgagcgacagcgtggtCgtgtgctgcggcgagtgctt	4	10	18	9	5	0	1	0	1	0	0	1	3	0	1	0	2	6	3	0	2	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr13:107145598C>T	uc001vqi.2	-	5	817	c.792G>A	c.(790-792)ACG>ACA	p.T264T		NM_004093	NP_004084	P52799	EFNB2_HUMAN	ephrin B2 precursor	264	Cytoplasmic (Potential).				cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			ovary(1)	1	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					ACAGCGTGGTCGTGTGCTGCG	0.522													20	24					0	0	0	0	T	107145598	T	T	107145598	2	4	29	1	0	0	0	0	0	0	0	1	4978	871	31	1		1	EFNB2	13	107145598	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	60550957	107145598	8024280	327	5861											
ANKRD10	55608	broad.mit.edu	37	chr13	111567112	111567112	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtgcacgggcgtccagccaTagaaggagtcctcagaggcc	10	5	14	12	2	1	2	1	0	0	2	3	3	3	3	4	3	2	1	4	3	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr13:111567112T>C	uc001vrn.2	-	1	305	c.170A>G	c.(169-171)TAT>TGT	p.Y57C	ANKRD10_uc001vro.1_Missense_Mutation_p.Y57C|ANKRD10_uc001vrp.1_Missense_Mutation_p.Y57C	NM_017664	NP_060134	Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	57	ANK 2.									central_nervous_system(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			CGTCCAGCCATAGAAGGAGTC	0.677													6	3					0	0	0	0	C	111567112	C	C	111567112	3	2	29	1	0	0	0	0	1	0	0	0	638	1406	49	5	1116	5	ANKRD10	13	111567112	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	4421514	111567112	3602766	328	5862											
OR4K5	79317	broad.mit.edu	37	chr14	20389165	20389165	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcaaacccttatactatgtgGtcatcatgagccgaaggaca	13	9	9	10	1	2	1	2	1	0	0	2	3	2	2	2	2	3	1	2	2	5	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr14:20389165G>T	uc010tkw.1	+	1	400	c.400G>T	c.(400-402)GTC>TTC	p.V134F		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATACTATGTGGTCATCATGAG	0.443													66	57					1.34159e-35	1.84333e-35	1	0	T	20389165	T	T	20389165	3	4	29	1	0	0	0	0	1	0	0	0	11127	1261	44	4	402	4	OR4K5	14	20389165	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08		20389165	86960375	329	5863											
NDRG2	57447	broad.mit.edu	37	chr14	21487854	21487854	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggttgggtgcatgtgtaatGatatttctgtacttttgtat	8	19	11	3	0	1	1	0	1	1	0	1	1	1	1	0	2	2	5	0	2	4	8			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr14:21487854G>A	uc001vyy.2	-	11	810	c.660C>T	c.(658-660)ATC>ATT	p.I220I	NDRG2_uc010tll.1_Silent_p.I216I|NDRG2_uc001vyt.2_Silent_p.I133I|NDRG2_uc001vyu.2_Silent_p.I177I|NDRG2_uc001vyv.2_Silent_p.I206I|NDRG2_uc001vyw.2_Silent_p.I206I|NDRG2_uc001vzb.2_Silent_p.I160I|NDRG2_uc001vyx.2_Silent_p.I220I|NDRG2_uc001vza.2_Silent_p.I206I|NDRG2_uc001vyz.2_Silent_p.I206I|NDRG2_uc001vzc.2_Silent_p.I206I|NDRG2_uc001vze.2_Silent_p.I220I|NDRG2_uc001vzd.2_Silent_p.I220I|NDRG2_uc001vzg.2_Silent_p.I206I|NDRG2_uc001vzf.2_Silent_p.I206I|NDRG2_uc010aig.2_Silent_p.I220I	NM_201540	NP_963834	Q9UN36	NDRG2_HUMAN	N-myc downstream-regulated gene 2 isoform a	220					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				ovary(1)|breast(1)	2	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		CATGTGTAATGATATTTCTGT	0.403													18	14					0	0	0	0	A	21487854	A	A	21487854	2	1	29	1	0	0	0	0	0	0	0	1	10306	1280	45	2		2	NDRG2	14	21487854	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1098689	21487854	85861686	330	5864											
C14orf135	64430	broad.mit.edu	37	chr14	60592508	60592508	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaattttacaagaaaagccAtacttgttttctctggggta	12	14	8	7	0	1	1	0	0	1	1	2	1	1	1	1	2	3	3	1	2	7	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr14:60592508A>T	uc001xer.3	+	9	3054	c.2532A>T	c.(2530-2532)CCA>CCT	p.P844P	C14orf135_uc001xeq.2_Silent_p.P844P|C14orf135_uc010apm.2_RNA	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	1078						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		AAGAAAAGCCATACTTGTTTT	0.299													12	6					0	0	0	0	T	60592508	T	T	60592508	2	4	29	1	0	0	0	0	0	0	0	1	1751	204	8	5		5	C14orf135	14	60592508	Silent	SNP	A	TCGA-BB-7862-01A-21D-2229-08	39104654	60592508	46757032	331	5865											
LTBP2	4053	broad.mit.edu	37	chr14	75022287	75022287	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctggtcccgggggcagggCgttggaagagagctggctac	6	6	19	10	2	0	1	0	0	0	1	1	3	1	2	2	6	2	4	2	6	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr14:75022287C>T	uc001xqa.2	-	4	1327	c.940G>A	c.(940-942)GCC>ACC	p.A314T		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	314					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGGGGCAGGGCGTTGGAAGAG	0.652													18	74					0	0	0	0	T	75022287	T	T	75022287	3	4	29	1	0	0	0	0	1	0	0	0	9124	768	27	1	4657	1	LTBP2	14	75022287	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	14429779	75022287	32327253	332	5866											
NRXN3	9369	broad.mit.edu	37	chr14	79181141	79181141	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcacgccattcaccgccaGtggggagagcgagatcctgg	8	5	15	13	4	1	2	1	0	0	2	2	4	2	2	4	3	1	1	4	3	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr14:79181141G>A	uc001xun.2	+	5	1075	c.584G>A	c.(583-585)AGT>AAT	p.S195N	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.S329N	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	568	Extracellular (Potential).|Laminin G-like 3.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TTCACCGCCAGTGGGGAGAGC	0.572													80	89					0	0	0	0	A	79181141	A	A	79181141	3	1	29	1	0	0	0	0	1	0	0	0	10721	1029	36	4	594	4	NRXN3	14	79181141	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4158854	79181141	28168399	333	5867											
KCNK10	54207	broad.mit.edu	37	chr14	88658719	88658719	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatgaacaggatggttgaGatgacccggatcttggtctg	11	10	14	6	1	2	4	0	3	2	2	2	7	2	6	1	4	1	1	1	4	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr14:88658719G>T	uc001xwo.2	-	5	1159	c.702C>A	c.(700-702)ATC>ATA	p.I234I	KCNK10_uc001xwm.2_Silent_p.I239I|KCNK10_uc001xwn.2_Silent_p.I239I	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	234	Helical; (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						GGATGGTTGAGATGACCCGGA	0.493													46	47					1.42923e-14	1.72118e-14	1	0	T	88658719	T	T	88658719	2	4	29	1	0	0	0	0	0	0	0	1	8098	932	33	2		2	KCNK10	14	88658719	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	9477578	88658719	18690821	334	5868											
SERPINA10	51156	broad.mit.edu	37	chr14	94754646	94754646	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttcatgtttctgagccaTgtctccaccaagtctgtggt	6	16	9	10	0	4	1	1	1	3	0	5	1	4	1	3	1	1	2	3	1	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr14:94754646T>A	uc001yct.2	-	3	1435	c.969A>T	c.(967-969)ACA>ACT	p.T323T	SERPINA10_uc001ycu.3_Silent_p.T323T	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	323					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TTCTGAGCCATGTCTCCACCA	0.493													33	27					0	0	0	0	A	94754646	A	A	94754646	2	1	29	1	0	0	0	0	0	0	0	1	14152	1451	51	5		5	SERPINA10	14	94754646	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	6095927	94754646	12594894	335	5869											
C14orf49	161176	broad.mit.edu	37	chr14	95918720	95918720	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggccagcgccgcccgtgttgCctgcagcacatgacgacacc	7	5	12	17	4	0	1	0	1	0	0	0	2	0	1	5	1	4	3	5	1	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr14:95918720C>T	uc001yei.3	-	6	1153	c.1138G>A	c.(1138-1140)GCA>ACA	p.A380T	C14orf49_uc010avi.2_Missense_Mutation_p.A380T|C14orf49_uc001yej.1_Missense_Mutation_p.A380T	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	380	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		GCCCGTGTTGCCTGCAGCACA	0.652											OREG0022900	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	26					0	0	0	0	T	95918720	T	T	95918720	3	4	29	1	0	0	0	0	1	0	0	0	1782	753	26	4	1837	4	C14orf49	14	95918720	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1164074	95918720	11430820	336	5870											
OR4M2	390538	broad.mit.edu	37	chr15	22368660	22368660	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtccaactagtcctatttGttatatttctatccttctat	9	19	4	9	0	2	0	0	0	2	0	5	0	5	0	3	1	1	1	3	1	7	9			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:22368660G>C	uc010tzu.1	+	1	85	c.85G>C	c.(85-87)GTT>CTT	p.V29L	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		AGTCCTATTTGTTATATTTCT	0.393													95	296					0	0	0	0	C	22368660	C	C	22368660	3	2	29	1	0	0	0	0	1	0	0	0	11130	1377	48	4	87	4	OR4M2	15	22368660	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08		22368660	80162732	337	5871											
MKRN3	7681	broad.mit.edu	37	chr15	23812141	23812141	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggcctgcaggtattttgcGgaaggcaggggtaactgccc	9	8	15	9	1	0	0	0	0	0	0	0	1	0	1	2	6	4	4	2	6	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:23812141G>A	uc001ywh.3	+	1	1688	c.1212G>A	c.(1210-1212)GCG>GCA	p.A404A	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Intron	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	404	C3H1-type 3.					ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GGTATTTTGCGGAAGGCAGGG	0.522													33	116					0	0	0	0	A	23812141	A	A	23812141	2	1	29	1	0	0	0	0	0	0	0	1	9661	1103	39	1		1	MKRN3	15	23812141	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1443481	23812141	78719251	338	5872											
C15orf2	23742	broad.mit.edu	37	chr15	24923265	24923265	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccaccagtttgcctgcaCagtcagtcagggcaccagct	8	8	10	15	0	2	0	2	0	0	0	3	0	3	0	4	1	3	5	4	1	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:24923265C>G	uc001ywo.2	+	1	2725	c.2251C>G	c.(2251-2253)CAG>GAG	p.Q751E		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	751					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TTTGCCTGCACAGTCAGTCAG	0.562													194	114					0	0	0	0	G	24923265	G	G	24923265	3	3	29	1	0	0	0	0	1	0	0	0	1790	479	17	4	2253	4	C15orf2	15	24923265	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1111124	24923265	77608127	339	5873											
ATP10A	57194	broad.mit.edu	37	chr15	25947134	25947134	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggcatatgcaatgttgaCagctgtttcttgtttgtcac	8	15	10	8	0	2	1	1	1	1	0	2	1	2	1	0	1	2	7	0	1	2	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:25947134C>A	uc010ayu.2	-	13	2795	c.2689G>T	c.(2689-2691)GTC>TTC	p.V897F		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	897	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCAATGTTGACAGCTGTTTCT	0.532													50	150					1.57914e-17	1.96714e-17	1	0	A	25947134	A	A	25947134	3	1	29	1	0	0	0	0	1	0	0	0	1118	478	17	4	1846	4	ATP10A	15	25947134	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1023869	25947134	76584258	340	5874											
RYR3	6263	broad.mit.edu	37	chr15	33916022	33916022	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacagagtacgtttcctgaTgggtggacgtcatggagagt	9	11	15	6	2	1	4	1	2	0	2	2	6	2	5	1	3	1	2	1	3	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:33916022T>A	uc001zhi.2	+	20	2442	c.2372T>A	c.(2371-2373)ATG>AAG	p.M791K	RYR3_uc010bar.2_Missense_Mutation_p.M791K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	791	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CGTTTCCTGATGGGTGGACGT	0.423													34	33					0	0	0	0	A	33916022	A	A	33916022	3	1	29	1	0	0	0	0	1	0	0	0	13835	1464	51	5	2450	5	RYR3	15	33916022	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	7968888	33916022	68615370	341	5875											
RYR3	6263	broad.mit.edu	37	chr15	33926903	33926903	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgcacttttgttggttacggGtataacattgagccatcaga	10	13	10	8	2	1	2	1	1	0	1	1	2	1	2	1	2	3	4	1	2	3	7	rs2291733		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:33926903G>A	uc001zhi.2	+	25	3214	c.3144G>A	c.(3142-3144)GGG>GGA	p.G1048G	RYR3_uc010bar.2_Silent_p.G1048G	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1048	2.|B30.2/SPRY 2.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGGTTACGGGTATAACATTG	0.483													69	90					0	0	0	0	A	33926903	A	A	33926903	2	1	29	1	0	0	0	0	0	0	0	1	13835	1248	44	4		4	RYR3	15	33926903	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	10881	33926903	68604489	342	5876											
ZFP106	64397	broad.mit.edu	37	chr15	42742648	42742648	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcactttcatcttctagtgCgtgcacttgaaactcaattt	10	16	5	10	1	5	1	3	1	2	0	5	1	5	1	0	0	3	1	0	0	3	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:42742648C>A	uc001zpw.2	-	2	2088	c.1753G>T	c.(1753-1755)GCA>TCA	p.A585S	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Missense_Mutation_p.A368S|ZFP106_uc001zpy.1_Missense_Mutation_p.A608S	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	585						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		TCTTCTAGTGCGTGCACTTGA	0.388													111	95					1.06059e-47	1.48541e-47	1	0	A	42742648	A	A	42742648	3	1	29	1	0	0	0	0	1	0	0	0	17704	768	27	3	3970	3	ZFP106	15	42742648	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	8815745	42742648	59788744	343	5877											
SHC4	399694	broad.mit.edu	37	chr15	49143384	49143384	+	Splice_Site	DEL	C	-	-																															ggagaagggcattgtacctaCctattgccctgctttgttct																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:49143384delC	uc001zxb.1	-	9	1732	c.1303_splice	c.e9+1	p.G435_splice	SHC4_uc010uey.1_Splice_Site_p.G192_splice|SHC4_uc010uez.1_Splice_Site_p.G149_splice	NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein						intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		ATTGTACCTACCTATTGCCCT	0.413													---	---	---								-	49143384	-	-	49143384	8	5	29	1	0	1	0	1	0	0	1	0	14338	521	18	0	604	0	SHC4	15	49143384	Splice_Site	DEL	C	TCGA-BB-7862-01A-21D-2229-08	6400736	49143384	53388008	344	5878											
SHC4	399694	broad.mit.edu	37	chr15	49254847	49254847	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccgctggaacctgggtcccgGctttcctggagcttcagccg	4	9	13	15	3	1	0	1	0	0	0	3	2	3	2	5	4	3	3	5	4	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:49254847G>A	uc001zxb.1	-	1	795	c.366C>T	c.(364-366)AGC>AGT	p.S122S		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	122	CH2.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		CTGGGTCCCGGCTTTCCTGGA	0.597													15	41					0	0	0	0	A	49254847	A	A	49254847	2	1	29	1	0	0	0	0	0	0	0	1	14338	1194	42	4		4	SHC4	15	49254847	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	111463	49254847	53276545	345	5879											
PRTG	283659	broad.mit.edu	37	chr15	55933315	55933315	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catggctttcacttacacacGcatcctggagtgctgacagt	9	11	9	12	1	1	1	1	1	0	0	2	2	2	2	1	2	2	3	1	2	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:55933315G>A	uc002adg.2	-	12	2181	c.2133C>T	c.(2131-2133)TGC>TGT	p.C711C		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	711					multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		ACTTACACACGCATCCTGGAG	0.448													7	17					0	0	0	0	A	55933315	A	A	55933315	2	1	29	1	0	0	0	0	0	0	0	1	12700	1079	38	1		1	PRTG	15	55933315	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	6678468	55933315	46598077	346	5880											
MYO1E	4643	broad.mit.edu	37	chr15	59553688	59553688	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgaaagggttgactgagatTaatacagatcctatatatgt	14	14	9	4	0	0	4	0	3	0	2	1	5	1	4	1	1	1	1	1	1	6	7			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:59553688T>C	uc002aga.2	-	3	540	c.168A>G	c.(166-168)TTA>TTG	p.L56L		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	56	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		TGACTGAGATTAATACAGATC	0.338													53	33					0	0	0	0	C	59553688	C	C	59553688	2	2	29	1	0	0	0	0	0	0	0	1	10125	1751	61	5		5	MYO1E	15	59553688	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	3620373	59553688	42977704	347	5881											
IGF1R	3480	broad.mit.edu	37	chr15	99460071	99460071	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaataccgcaaagtctttGagaatttcctgcacaactcc	12	11	6	12	1	1	2	0	2	1	1	3	3	3	2	3	0	3	2	3	0	5	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr15:99460071G>C	uc002bul.2	+	10	2217	c.2167G>C	c.(2167-2169)GAG>CAG	p.E723Q	IGF1R_uc010urq.1_Missense_Mutation_p.E723Q|IGF1R_uc010bon.2_Missense_Mutation_p.E723Q|IGF1R_uc010urr.1_Missense_Mutation_p.E173Q	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	723					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CAAAGTCTTTGAGAATTTCCT	0.542													21	27					0	0	0	0	C	99460071	C	C	99460071	3	2	29	1	0	0	0	0	1	0	0	0	7610	1291	45	2	2205	2	IGF1R	15	99460071	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	39906383	99460071	3071321	348	5882											
TELO2	9894	broad.mit.edu	37	chr16	1544453	1544453	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaggaggagtttgcctcggcCcacttctcgcctgtcctcag	6	10	11	14	2	2	0	1	0	1	0	5	2	3	2	4	3	1	1	4	3	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr16:1544453C>T	uc002cly.2	+	2	462	c.171C>T	c.(169-171)GCC>GCT	p.A57A	TELO2_uc010uvg.1_Silent_p.A57A	NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	57						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				TTGCCTCGGCCCACTTCTCGC	0.647											OREG0023547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	94	170					0	0	0	0	T	1544453	T	T	1544453	2	4	29	1	0	0	0	0	0	0	0	1	15823	610	22	4		4	TELO2	16	1544453	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08		1544453	88810300	349	5883											
A2BP1	54715	broad.mit.edu	37	chr16	7568151	7568151	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctttttgatttttcagggTaatcaggaagcagccgctgc	9	13	10	9	1	2	1	2	1	0	0	2	2	2	2	2	2	3	3	2	2	2	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr16:7568151T>C	uc002cys.2	+	5	1018	c.30T>C	c.(28-30)GGT>GGC	p.G10G	A2BP1_uc010buf.1_Silent_p.G10G|A2BP1_uc002cyr.1_Silent_p.G10G|A2BP1_uc002cyt.2_Silent_p.G10G|A2BP1_uc010uxz.1_Silent_p.G53G|A2BP1_uc010uya.1_Silent_p.G46G|A2BP1_uc002cyv.1_Silent_p.G10G|A2BP1_uc010uyb.1_Silent_p.G10G|A2BP1_uc002cyw.2_Silent_p.G30G|A2BP1_uc002cyy.2_Silent_p.G30G|A2BP1_uc002cyx.2_Silent_p.G30G|A2BP1_uc010uyc.1_Silent_p.G30G	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	10					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TTTTTCAGGGTAATCAGGAAG	0.587													101	224					0	0	0	0	C	7568151	C	C	7568151	2	2	29	1	0	0	0	0	0	0	0	1	3	1625	57	5		5	A2BP1	16	7568151	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	6023698	7568151	82786602	350	5884											
ZC3H7A	29066	broad.mit.edu	37	chr16	11862237	11862237	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccttcgaggggatgtcttgGagtcactgatgaagatggtt	8	13	14	6	1	2	3	1	2	1	1	4	6	3	5	1	4	0	1	1	4	1	3	rs147099217		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr16:11862237G>A	uc002dbk.2	-	11	1492	c.1294C>T	c.(1294-1296)CCA>TCA	p.P432S	ZC3H7A_uc002dbj.2_5'Flank|ZC3H7A_uc002dbl.2_Missense_Mutation_p.P432S|ZC3H7A_uc002dbm.1_Missense_Mutation_p.P342S	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	432						nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						GGATGTCTTGGAGTCACTGAT	0.413													41	95					0	0	0	0	A	11862237	A	A	11862237	3	1	29	1	0	0	0	0	1	0	0	0	17639	1174	41	2	1669	2	ZC3H7A	16	11862237	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4294086	11862237	78492516	351	5885											
NOMO1	23420	broad.mit.edu	37	chr16	14976452	14976452	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgagtttttttgcagcCgggatgtgtgtaccacgttc	5	15	11	10	2	0	1	0	1	0	0	2	2	1	2	3	1	3	4	3	1	1	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr16:14976452C>T	uc002dcv.2	+	26	3095	c.3029C>T	c.(3028-3030)CCG>CTG	p.P1010L		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	1010	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						TTTTTGCAGCCGGGATGTGTG	0.547													66	141					0	0	0	0	T	14976452	T	T	14976452	3	4	29	1	0	0	0	0	1	0	0	0	10585	666	23	1	3131	1	NOMO1	16	14976452	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	3114215	14976452	75378301	352	5886											
GPRC5B	51704	broad.mit.edu	37	chr16	19883697	19883697	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccaccagctgccagcccgcGgggcccgtgccatgccgcac	5	3	12	21	4	0	0	0	0	0	0	0	0	0	0	7	2	5	2	7	2	0	0	rs144341472		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr16:19883697G>T	uc002dgt.2	-	2	579	c.471C>A	c.(469-471)CCC>CCA	p.P157P	GPRC5B_uc010vav.1_Silent_p.P183P	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	157	Cytoplasmic (Potential).									lung(1)|breast(1)|skin(1)	3						GCCAGCCCGCGGGGCCCGTGC	0.687													18	60					8.28177e-16	1.01667e-15	1	0	T	19883697	T	T	19883697	2	4	29	1	0	0	0	0	0	0	0	1	6764	1103	39	3		3	GPRC5B	16	19883697	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4907245	19883697	70471056	353	5887											
ACSM2A	123876	broad.mit.edu	37	chr16	20497919	20497919	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtttgtcttgaacctgccCaagactgtcacagggaaaat	12	10	10	9	0	2	2	1	1	1	1	2	4	2	3	2	1	2	1	2	1	4	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr16:20497919C>A	uc010bwe.2	+	15	1892	c.1653C>A	c.(1651-1653)CCC>CCA	p.P551P	ACSM2A_uc002dhf.3_Silent_p.P551P|ACSM2A_uc002dhg.3_Silent_p.P551P|ACSM2A_uc010vay.1_Silent_p.P472P|ACSM2A_uc002dhh.3_Silent_p.P181P|uc002dhi.1_5'Flank	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	551					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						TGAACCTGCCCAAGACTGTCA	0.478													77	168					1.42074e-37	1.96271e-37	1	0	A	20497919	A	A	20497919	2	1	29	1	0	0	0	0	0	0	0	1	183	581	21	4		4	ACSM2A	16	20497919	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	614222	20497919	69856834	354	5888											
TAOK2	9344	broad.mit.edu	37	chr16	29990342	29990342	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatcgcagctgtgacccacGgggcgcttcagggcctggca	7	6	15	13	3	1	2	1	1	0	1	2	2	1	2	2	4	1	4	2	4	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr16:29990342G>T	uc002dva.1	+	6	1183	c.400G>T	c.(400-402)GGG>TGG	p.G134W	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.G134W|TAOK2_uc002dvc.1_Missense_Mutation_p.G134W|TAOK2_uc010bzm.1_Missense_Mutation_p.G134W|TAOK2_uc002dvd.1_5'Flank	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	134	Protein kinase.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						TGTGACCCACGGGGCGCTTCA	0.587													63	176					3.82405e-32	5.17012e-32	1	0	T	29990342	T	T	29990342	3	4	29	1	0	0	0	0	1	0	0	0	15614	1116	39	3	418	3	TAOK2	16	29990342	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	9492423	29990342	60364411	355	5889											
SRCAP	10847	broad.mit.edu	37	chr16	30748559	30748559	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctcgtgtcagtgagcgtcttCgtggagcccgggctgagact	5	10	15	11	4	2	2	1	2	1	1	4	4	2	3	1	2	2	1	1	2	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr16:30748559C>G	uc002dze.1	+	34	7583	c.7198C>G	c.(7198-7200)CGT>GGT	p.R2400G	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.R2195G	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2400					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGAGCGTCTTCGTGGAGCCCG	0.627													36	62					0	0	0	0	G	30748559	G	G	30748559	3	3	29	1	0	0	0	0	1	0	0	0	15201	884	31	3	7324	3	SRCAP	16	30748559	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	758217	30748559	59606194	356	5890											
HPR	3250	broad.mit.edu	37	chr16	72108244	72108244	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtggagcacttgtttcgctaCcagtgtaagaactactacag	11	11	10	9	1	0	1	0	0	0	1	1	2	0	2	1	1	5	4	1	1	5	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr16:72108244C>G	uc002fby.2	+	3	183	c.153C>G	c.(151-153)TAC>TAG	p.Y51*	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	51	Sushi.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				TGTTTCGCTACCAGTGTAAGA	0.488													31	28					0	0	0	0	G	72108244	G	G	72108244	4	3	29	1	0	0	0	0	0	1	0	0	7376	518	18	4	163	4	HPR	16	72108244	Nonsense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	41359685	72108244	18246509	357	5891											
OR3A3	8392	broad.mit.edu	37	chr17	3324532	3324532	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcacccttggtcttcatcaGtgtgtcctatgcccatgtgg	5	13	11	12	0	3	0	2	0	1	0	4	0	4	0	3	3	1	1	3	3	1	3	rs143627345	by1000genomes	TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:3324532G>T	uc010vrd.1	+	1	671	c.671G>T	c.(670-672)AGT>ATT	p.S224I		NM_012373	NP_036505	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A,	224	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTCTTCATCAGTGTGTCCTAT	0.567													27	15					7.76418e-22	1.00164e-21	1	0	T	3324532	T	T	3324532	3	4	29	1	0	0	0	0	1	0	0	0	11093	1029	36	4	673	4	OR3A3	17	3324532	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08		3324532	77870678	358	5892											
TRPV1	7442	broad.mit.edu	37	chr17	3495362	3495362	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccagacgcggacttaccTggcaccggtggggccgtctc	5	7	14	15	4	1	1	0	0	1	1	3	2	2	2	4	5	1	2	4	5	1	1	rs56016548		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:3495362T>C	uc010vrr.1	-	1	810	c.283A>G	c.(283-285)AGG>GGG	p.R95G	TRPV1_uc010vro.1_Missense_Mutation_p.R95G|TRPV1_uc010vrp.1_Missense_Mutation_p.R95G|TRPV1_uc010vrq.1_Silent_p.P69P|TRPV1_uc010vrs.1_Missense_Mutation_p.R95G|TRPV1_uc010vrt.1_Missense_Mutation_p.R95G|TRPV1_uc010vru.1_Missense_Mutation_p.R95G	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,	95	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	CGGACTTACCTGGCACCGGTG	0.632													6	16					0	0	0	0	C	3495362	C	C	3495362	3	2	29	1	0	0	0	0	1	0	0	0	16662	1594	55	5	1969	5	TRPV1	17	3495362	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	170830	3495362	77699848	359	5893											
ALOX15	246	broad.mit.edu	37	chr17	4542794	4542794	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acaagggaacctgacctcgtCcccggctccggggccctgca	7	5	12	17	3	0	1	0	1	0	0	3	2	2	2	6	4	2	2	6	4	2	0	rs11568142	byFrequency	TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:4542794C>G	uc002fyh.2	-	2	282	c.268G>C	c.(268-270)GAC>CAC	p.D90H	ALOX15_uc010vsd.1_Missense_Mutation_p.D51H|ALOX15_uc010vse.1_Missense_Mutation_p.D112H	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	90	PLAT.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	CTGACCTCGTCCCCGGCTCCG	0.652													6	22					0	0	0	0	G	4542794	G	G	4542794	3	3	29	1	0	0	0	0	1	0	0	0	538	855	30	2	1772	2	ALOX15	17	4542794	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1047432	4542794	76652416	360	5894											
TP53	7157	broad.mit.edu	37	chr17	7578461	7578461	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagatggccatggcgcggaCgcgggtgccgggcgggggtg	4	5	23	9	6	0	1	0	0	0	1	0	2	0	2	2	7	1	1	2	7	1	1	rs121912654		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:7578461C>A	uc002gim.2	-	5	663	c.469G>T	c.(469-471)GTC>TTC	p.V157F	TP53_uc002gig.1_Missense_Mutation_p.V157F|TP53_uc002gih.2_Missense_Mutation_p.V157F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V25F|TP53_uc010cng.1_Missense_Mutation_p.V25F|TP53_uc002gii.1_Missense_Mutation_p.V25F|TP53_uc010cnh.1_Missense_Mutation_p.V157F|TP53_uc010cni.1_Missense_Mutation_p.V157F|TP53_uc002gij.2_Missense_Mutation_p.V157F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V64F|TP53_uc002gio.2_Missense_Mutation_p.V25F|TP53_uc010vug.1_Missense_Mutation_p.V118F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	157	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> I (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> F (in sporadic cancers; somatic mutation).|V -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V157F(139)|p.V157I(10)|p.V157D(8)|p.V157G(7)|p.0?(7)|p.V157L(6)|p.V157V(5)|p.V157fs*13(3)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.V157fs*22(2)|p.V157fs*24(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.V157A(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.D148fs*23(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.V157fs*25(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCGCGGACGCGGGTGCCG	0.617		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			37	37					1.04594e-18	1.31586e-18	1	0	A	7578461	A	A	7578461	3	1	29	1	0	0	0	0	1	0	0	0	16448	536	19	3	829	3	TP53	17	7578461	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	3035667	7578461	73616749	361	5895											
TNFRSF13B	23495	broad.mit.edu	37	chr17	16843706	16843708	+	In_Frame_Del	DEL	TCT	-	-																															gcaggagcagggatccccccTcttcttgaggaagcaggcca																								rs74811083	byFrequency	TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:16843706_16843708delTCT	uc002gqs.1	-	4	576_578	c.563_565delAGA	c.(562-567)AAGAGG>AGG	p.K188del	TNFRSF13B_uc010vwt.1_RNA|TNFRSF13B_uc002gqt.1_In_Frame_Del_p.K142del	NM_012452	NP_036584	O14836	TR13B_HUMAN	tumor necrosis factor receptor 13B	188	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity			kidney(2)	2						GGATCCCCCCTCTTCTTGAGGAA	0.645									IgA_Deficiency_Selective				---	---	---								-	16843708	-	-	16843706	7	5	29	1	0	1	0	1	0	0	0	0	16353	1550	54	0	324	0	TNFRSF13B	17	16843706	In_Frame_Del	DEL	TCT	TCGA-BB-7862-01A-21D-2229-08	9265245	16843706	64351504	362	5896											
SLC13A2	9058	broad.mit.edu	37	chr17	26821423	26821423	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagtagaaaacccagggaagCtgaaggcccctcttggcctc	12	6	11	12	0	1	2	0	1	1	1	2	3	1	3	4	3	2	2	4	3	6	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:26821423C>A	uc002hbh.2	+	9	1268	c.1201C>A	c.(1201-1203)CTG>ATG	p.L401M	SLC13A2_uc010wam.1_Missense_Mutation_p.L357M|SLC13A2_uc010wan.1_Missense_Mutation_p.L450M|SLC13A2_uc010wao.1_Missense_Mutation_p.L358M|SLC13A2_uc002hbi.2_Missense_Mutation_p.L330M	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	401						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CCCAGGGAAGCTGAAGGCCCC	0.567											OREG0024276	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	56					1.66031e-10	1.88739e-10	1	0	A	26821423	A	A	26821423	3	1	29	1	0	0	0	0	1	0	0	0	14457	796	28	4	1382	4	SLC13A2	17	26821423	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	9977717	26821423	54373787	363	5897											
SUPT6H	6830	broad.mit.edu	37	chr17	27013800	27013800	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctctatatgaacagcaagaAgtcagaggtaatgctggagc	14	9	11	7	0	2	3	1	1	1	2	3	4	2	4	0	2	4	3	0	2	6	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:27013800A>T	uc002hby.2	+	21	2783	c.2693A>T	c.(2692-2694)AAG>ATG	p.K898M	SUPT6H_uc010crt.2_Missense_Mutation_p.K898M|SUPT6H_uc002hbz.1_5'Flank	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	898					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					AACAGCAAGAAGTCAGAGGTA	0.488													16	24					0	0	0	0	T	27013800	T	T	27013800	3	4	29	1	0	0	0	0	1	0	0	0	15466	72	3	5	2771	5	SUPT6H	17	27013800	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	192377	27013800	54181410	364	5898											
KRT31	3881	broad.mit.edu	37	chr17	39551868	39551868	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagctggcagcgcagggtaTtgacctcctatggatgcaga	10	8	13	10	1	0	2	0	1	0	1	1	3	1	3	2	3	3	5	2	3	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:39551868T>C	uc002hwn.2	-	4	649	c.596A>G	c.(595-597)AAT>AGT	p.N199S	KRT31_uc010cxn.2_Missense_Mutation_p.N199S	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	199	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				GCGCAGGGTATTGACCTCCTA	0.483													26	39					0	0	0	0	C	39551868	C	C	39551868	3	2	29	1	0	0	0	0	1	0	0	0	8506	1493	52	5	670	5	KRT31	17	39551868	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	12538068	39551868	41643342	365	5899											
KAT2A	2648	broad.mit.edu	37	chr17	40269097	40269097	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcacagaagacaatctccgTgaagccctgggtgggaaaca	14	5	12	10	1	1	3	0	1	1	2	2	4	1	4	2	2	3	1	2	2	4	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:40269097T>C	uc002hyx.2	-	11	1780	c.1720A>G	c.(1720-1722)ACG>GCG	p.T574A		NM_021078	NP_066564	Q92830	KAT2A_HUMAN	general control of amino acid synthesis 5-like	574	N-acetyltransferase.				chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			upper_aerodigestive_tract(1)|lung(1)	2						ACAATCTCCGTGAAGCCCTGG	0.617											OREG0024419	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	83					0	0	0	0	C	40269097	C	C	40269097	3	2	29	1	0	0	0	0	1	0	0	0	8020	1696	59	5	825	5	KAT2A	17	40269097	Missense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	717229	40269097	40926113	366	5900											
RAMP2	10266	broad.mit.edu	37	chr17	40914628	40914628	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctaggccttatagcaccCtgcgagattgcctggagcac	8	8	10	15	1	0	1	0	0	0	1	0	3	0	2	5	2	4	2	5	2	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:40914628C>T	uc002ibg.2	+	4	354	c.286C>T	c.(286-288)CTG>TTG	p.L96L	LOC100190938_uc002ibd.1_5'Flank|LOC100190938_uc002ibe.3_5'Flank|LOC100190938_uc002ibf.3_5'Flank|RAMP2_uc010cyt.2_Silent_p.L101L|RAMP2_uc002ibh.2_Silent_p.P59P	NM_005854	NP_005845	O60895	RAMP2_HUMAN	receptor activity modifying protein 2 precursor	96	Extracellular (Potential).				intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	coated pit|integral to plasma membrane|lysosome	protein transporter activity				0		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0741)	Pramlintide(DB01278)	TTATAGCACCCTGCGAGATTG	0.552													43	64					0	0	0	0	T	40914628	T	T	40914628	2	4	29	1	0	0	0	0	0	0	0	1	13087	680	24	4		4	RAMP2	17	40914628	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	645531	40914628	40280582	367	5901											
ACBD4	79777	broad.mit.edu	37	chr17	43216410	43216411	+	Missense_Mutation	DNP	GG	TT	TT																															gggttgcggggcagcccgccGgggccccaggagttggacgt																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:43216410_43216411GG>TT	uc002iid.2	+	9	1006_1007	c.662_663GG>TT	c.(661-663)CGG>CTT	p.R221L	ACBD4_uc010wjj.1_Missense_Mutation_p.R237L|ACBD4_uc002iie.2_Missense_Mutation_p.R237L|ACBD4_uc002iif.2_Missense_Mutation_p.G225W|ACBD4_uc002iic.2_Missense_Mutation_p.G225W|ACBD4_uc010dae.2_Missense_Mutation_p.R159L	NM_001135707	NP_001129179	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	221							fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						GCAGCCCGCCGGGGCCCCAGGA	0.678													40	70					0	0	0	0	TT	43216411	TT	TT	43216410	3	4	29	1	0	0	0	0	1	0	0	0	124	1116	39	3	740	3	ACBD4	17	43216410	Missense_Mutation	DNP	GG	TCGA-BB-7862-01A-21D-2229-08	2301782	43216410	37978800	368	5902											
C17orf57	124989	broad.mit.edu	37	chr17	45456566	45456567	+	Frame_Shift_Ins	INS	-	A	A																															gagaatggaatggtggagttINSagatgactttgtaaatgctc																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:45456566_45456567insA	uc002iln.2	+	14	1940_1941	c.1529_1530insA	c.(1528-1530)TTAfs	p.L510fs	C17orf57_uc002ilm.2_Frame_Shift_Ins_p.L414fs|C17orf57_uc010daz.1_Frame_Shift_Ins_p.L462fs	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	510	EF-hand 1.						calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						ATGGTGGAGTTAGATGACTTTG	0.277													---	---	---								A	45456567	A	A	45456566	7	5	29	1	0	1	1	0	0	0	0	0	1872	1764	61	0	1571	0	C17orf57	17	45456566	Frame_Shift_Ins	INS	-	TCGA-BB-7862-01A-21D-2229-08	2240156	45456566	35738644	369	5903											
MRPL10	124995	broad.mit.edu	37	chr17	45906032	45906032	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acagtctggagggtaggcagCcggcctgggagggcatatag	9	6	18	8	1	1	0	0	0	1	0	1	2	1	2	2	6	1	3	2	6	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:45906032C>A	uc002ilz.2	-	2	83	c.57G>T	c.(55-57)CGG>CGT	p.R19R	MRPL10_uc010wky.1_5'UTR|MRPL10_uc002ily.2_Silent_p.R29R	NM_145255	NP_660298	Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10 precursor	19					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			ovary(1)	1						GGGTAGGCAGCCGGCCTGGGA	0.547													16	39					5.35267e-07	5.77405e-07	1	0	A	45906032	A	A	45906032	2	1	29	1	0	0	0	0	0	0	0	1	9828	726	26	4		4	MRPL10	17	45906032	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	449466	45906032	35289178	370	5904											
HOXB5	3215	broad.mit.edu	37	chr17	46669598	46669598	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggaaggcgctgccagctgtAgccaggctcatacttttcaa	9	10	11	11	1	2	0	2	0	0	0	2	1	2	1	2	3	4	4	2	3	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:46669598A>T	uc002inr.2	-	2	842	c.783T>A	c.(781-783)GCT>GCA	p.A261A	HOXB3_uc010wlm.1_5'Flank|HOXB3_uc010dbf.2_5'Flank|HOXB3_uc010dbg.2_5'Flank	NM_002147	NP_002138	P09067	HXB5_HUMAN	homeobox B5	261						nucleus	sequence-specific DNA binding				0						TGCCAGCTGTAGCCAGGCTCA	0.637													44	69					0	0	0	0	T	46669598	T	T	46669598	2	4	29	1	0	0	0	0	0	0	0	1	7343	407	15	5		5	HOXB5	17	46669598	Silent	SNP	A	TCGA-BB-7862-01A-21D-2229-08	763566	46669598	34525612	371	5905											
ANKFN1	162282	broad.mit.edu	37	chr17	54428145	54428145	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaattgtcgtgtgaaaatGacgcaacaaatgcaaaattt	17	10	9	5	2	0	2	0	2	0	0	1	3	0	3	0	1	2	2	0	1	7	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:54428145G>A	uc002iun.1	+	4	251	c.216G>A	c.(214-216)ATG>ATA	p.M72I		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	72										large_intestine(1)|ovary(1)	2						GTGTGAAAATGACGCAACAAA	0.388													57	62					0	0	0	0	A	54428145	A	A	54428145	3	1	29	1	0	0	0	0	1	0	0	0	625	1290	45	2	230	2	ANKFN1	17	54428145	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	7758547	54428145	26767065	372	5906											
C17orf47	284083	broad.mit.edu	37	chr17	56621330	56621330	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtccaggtcctgactggAgggagacagatcgagggtag	10	7	17	7	1	0	3	0	1	0	2	3	6	2	4	2	4	0	1	2	4	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:56621330A>C	uc002iwq.1	-	1	354	c.218T>G	c.(217-219)CTC>CGC	p.L73R		NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	73										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCCTGACTGGAGGGAGACAGA	0.567													47	51					0	0	0	0	C	56621330	C	C	56621330	3	2	29	1	0	0	0	0	1	0	0	0	1865	304	11	5	1502	5	C17orf47	17	56621330	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	2193185	56621330	24573880	373	5907											
CACNG5	27091	broad.mit.edu	37	chr17	64873613	64873613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgagatcaagatgtccctgCactcaggcctctggcgggtc	7	8	12	14	2	3	2	2	0	1	2	5	3	4	2	3	3	1	1	3	3	1	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:64873613C>T	uc010wqi.1	+	2	400	c.163C>T	c.(163-165)CAC>TAC	p.H55Y	CACNG5_uc002jfr.2_Missense_Mutation_p.H55Y|CACNG5_uc010wqj.1_Missense_Mutation_p.H55Y	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	55					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			GATGTCCCTGCACTCAGGCCT	0.637													60	69					0	0	0	0	T	64873613	T	T	64873613	3	4	29	1	0	0	0	0	1	0	0	0	2572	710	25	4	165	4	CACNG5	17	64873613	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	8252283	64873613	16321597	374	5908											
ARSG	22901	broad.mit.edu	37	chr17	66366632	66366632	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgagctagcgggcagtgtgGgtcccttcactggattttgg	5	12	16	8	1	1	1	1	1	0	0	2	2	2	2	1	4	2	2	1	4	1	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:66366632G>T	uc002jhc.2	+	8	1745	c.949G>T	c.(949-951)GGT>TGT	p.G317C	ARSG_uc002jhb.1_Missense_Mutation_p.G153C	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	317					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GGGCAGTGTGGGTCCCTTCAC	0.552													31	45					5.20837e-25	6.82337e-25	1	0	T	66366632	T	T	66366632	3	4	29	1	0	0	0	0	1	0	0	0	994	1232	43	4	975	4	ARSG	17	66366632	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1493019	66366632	14828578	375	5909											
CDR2L	30850	broad.mit.edu	37	chr17	72997561	72997562	+	Missense_Mutation	DNP	GG	TT	TT																															aggctggtgctggagagtaaGgctgcccagcagaagatcca																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:72997561_72997562GG>TT	uc002jml.3	+	3	730_731	c.318_319GG>TT	c.(316-321)AAGGCT>AATTCT	p.106_107KA>NS		NM_014603	NP_055418	Q86X02	CDR2L_HUMAN	cerebellar degeneration-related protein 2-like	106_107	Potential.										0	all_lung(278;0.226)					TGGAGAGTAAGGCTGCCCAGCA	0.658													9	12					0	0	0	0	TT	72997562	TT	TT	72997561	3	4	29	1	0	0	0	0	1	0	0	0	3188	991	35	4	328	4	CDR2L	17	72997561	Missense_Mutation	DNP	GG	TCGA-BB-7862-01A-21D-2229-08	6630929	72997561	8197649	376	5910											
UNK	85451	broad.mit.edu	37	chr17	73815859	73815859	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgccccacccaggaagcatCaccatcggtactgggtgtgg	8	7	13	13	1	1	0	1	0	0	0	2	1	1	1	4	4	3	2	4	4	2	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr17:73815859C>T	uc002jpm.2	+	13	1869	c.1869C>T	c.(1867-1869)ATC>ATT	p.I623I		NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	547							nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGGAAGCATCACCATCGGTA	0.627													28	62					0	0	0	0	T	73815859	T	T	73815859	2	4	29	1	0	0	0	0	0	0	0	1	17068	816	29	2		2	UNK	17	73815859	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	818298	73815859	7379351	377	5911											
COLEC12	81035	broad.mit.edu	37	chr18	334986	334986	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggcccggggggcctgggtcCccactggagccctgagggcc	3	4	19	15	1	0	1	0	1	0	0	1	2	1	2	6	7	1	0	6	7	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr18:334986C>T	uc002kkm.2	-	6	1787	c.1572G>A	c.(1570-1572)GGG>GGA	p.G524G		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	524	Collagen-like 2.|Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GGCCTGGGTCCCCACTGGAGC	0.721													7	10					0	0	0	0	T	334986	T	T	334986	2	4	29	1	0	0	0	0	0	0	0	1	3727	610	22	4		4	COLEC12	18	334986	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08		334986	77742262	378	5912											
LPIN2	9663	broad.mit.edu	37	chr18	2938026	2938026	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgatggtcagatcgttctcTtttgctgacctaaaaaagtt	11	15	8	7	1	2	3	1	2	1	1	4	3	2	3	1	1	1	3	1	1	3	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr18:2938026T>A	uc002klo.2	-	7	1071	c.832A>T	c.(832-834)AGA>TGA	p.R278*		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	278					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GATCGTTCTCTTTTGCTGACC	0.338													35	62					0	0	0	0	A	2938026	A	A	2938026	4	1	29	1	0	0	0	0	0	1	0	0	8969	1617	56	5	1914	5	LPIN2	18	2938026	Nonsense_Mutation	SNP	T	TCGA-BB-7862-01A-21D-2229-08	2603040	2938026	75139222	379	5913											
PTPRM	5797	broad.mit.edu	37	chr18	7955280	7955280	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatgaccggcagccagtcGattccacgagctataaaatt	13	8	10	10	3	0	1	0	1	0	0	2	4	1	2	3	2	2	2	3	2	4	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr18:7955280G>T	uc002knn.3	+	7	1503	c.1000G>T	c.(1000-1002)GAT>TAT	p.D334Y	PTPRM_uc010dkv.2_Missense_Mutation_p.D334Y|PTPRM_uc010wzl.1_Missense_Mutation_p.D121Y	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	334	Fibronectin type-III 1.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GCAGCCAGTCGATTCCACGAG	0.572													11	25					4.68919e-08	5.12375e-08	1	0	T	7955280	T	T	7955280	3	4	29	1	0	0	0	0	1	0	0	0	12871	1058	37	3	1026	3	PTPRM	18	7955280	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	5017254	7955280	70121968	380	5914											
KIAA0802	23255	broad.mit.edu	37	chr18	8819104	8819104	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtgcagatgctgactccatCccgtttgaagaccggccgct	7	10	11	13	3	0	4	0	2	0	2	2	4	2	4	4	1	2	4	4	1	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr18:8819104C>A	uc002knr.2	+	13	3145	c.3003C>A	c.(3001-3003)ATC>ATA	p.I1001I	KIAA0802_uc002knq.2_Silent_p.I960I|KIAA0802_uc002kns.2_Silent_p.I341I	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1311											0						CTGACTCCATCCCGTTTGAAG	0.602													12	45					4.36969e-10	4.9014e-10	1	0	A	8819104	A	A	8819104	2	1	29	1	0	0	0	0	0	0	0	1	8233	845	30	2		2	KIAA0802	18	8819104	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	863824	8819104	69258144	381	5915											
CEP192	55125	broad.mit.edu	37	chr18	13087592	13087592	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aataaaactgcaacagaactAtcaactgtatacttatttgg	17	12	5	7	0	1	1	1	0	0	1	1	1	1	1	0	1	6	2	0	1	10	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr18:13087592A>G	uc010xac.1	+	32	6020	c.5940A>G	c.(5938-5940)CTA>CTG	p.L1980L	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Silent_p.L1505L|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Silent_p.L402L|CEP192_uc002krw.2_Silent_p.L129L|CEP192_uc002krx.2_5'UTR|CEP192_uc002kry.2_5'Flank	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1980										ovary(4)|pancreas(1)	5						CAACAGAACTATCAACTGTAT	0.313													31	46					0	0	0	0	G	13087592	G	G	13087592	2	3	29	1	0	0	0	0	0	0	0	1	3266	436	16	5		5	CEP192	18	13087592	Silent	SNP	A	TCGA-BB-7862-01A-21D-2229-08	4268488	13087592	64989656	382	5916											
ASXL3	80816	broad.mit.edu	37	chr18	31263416	31263416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acattgacatagaaaccccaGgatctattcttgtcaacact	14	11	5	11	0	3	2	1	1	2	1	3	3	3	3	2	1	2	0	2	1	4	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr18:31263416G>A	uc010dmg.1	+	8	818	c.763G>A	c.(763-765)GGA>AGA	p.G255R	ASXL3_uc002kxq.2_5'UTR	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AGAAACCCCAGGATCTATTCT	0.418													14	6					0	0	0	0	A	31263416	A	A	31263416	3	1	29	1	0	0	0	0	1	0	0	0	1070	1001	35	4	793	4	ASXL3	18	31263416	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	18175824	31263416	46813832	383	5917											
ELAC1	55520	broad.mit.edu	37	chr18	48510848	48510848	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgtaaaagcatttcgcctCtttcacagaattccctcatt	10	15	5	11	1	3	1	2	0	1	1	5	1	4	1	2	0	1	3	2	0	3	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr18:48510848C>G	uc002lez.2	+	3	646	c.540C>G	c.(538-540)CTC>CTG	p.L180L	ELAC1_uc010dpe.2_Silent_p.L180L|SMAD4_uc010xdo.1_Intron	NM_018696	NP_061166	Q9H777	RNZ1_HUMAN	elaC homolog 1	180					tRNA 3'-trailer cleavage	nucleus	endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0		Colorectal(6;0.0269)|all_epithelial(6;0.0729)		Colorectal(21;0.000943)|COAD - Colon adenocarcinoma(17;0.0398)|READ - Rectum adenocarcinoma(32;0.0894)|STAD - Stomach adenocarcinoma(97;0.18)		CATTTCGCCTCTTTCACAGAA	0.388													13	9					0	0	0	0	G	48510848	G	G	48510848	2	3	29	1	0	0	0	0	0	0	0	1	5070	900	32	2		2	ELAC1	18	48510848	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	17247432	48510848	29566400	384	5918											
C19orf21	126353	broad.mit.edu	37	chr19	757706	757706	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaagccccaggtgaaggggGtggtcagggaagagaacaag	13	4	17	7	0	2	2	2	1	0	1	2	4	2	3	2	5	2	0	2	5	5	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:757706G>T	uc002lpo.2	+	2	843	c.760G>T	c.(760-762)GTG>TTG	p.V254L		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	254										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGAAGGGGGTGGTCAGGGA	0.657													21	22					1.96292e-10	2.2264e-10	1	0	T	757706	T	T	757706	3	4	29	1	0	0	0	0	1	0	0	0	1922	1261	44	4	762	4	C19orf21	19	757706	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08		757706	58371277	385	5919											
ATP8B3	148229	broad.mit.edu	37	chr19	1800001	1800001	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcaagatgttctgcgtgagCgtgcccgtcttgtccgagaa	7	11	13	10	4	3	3	1	1	2	2	4	4	4	3	2	0	3	1	2	0	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:1800001C>A	uc002ltw.2	-	14	1731	c.1497G>T	c.(1495-1497)ACG>ACT	p.T499T	ATP8B3_uc002ltv.2_Silent_p.T452T|ATP8B3_uc002ltx.2_RNA|ATP8B3_uc002lty.1_Silent_p.T247T|ATP8B3_uc002ltz.1_Silent_p.T446T	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	499	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGCGTGAGCGTGCCCGTCT	0.612													13	21					1.49906e-05	1.5703e-05	1	0	A	1800001	A	A	1800001	2	1	29	1	0	0	0	0	0	0	0	1	1198	755	27	3		3	ATP8B3	19	1800001	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1042295	1800001	57328982	386	5920											
TIMM13	26517	broad.mit.edu	37	chr19	2426974	2426974	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctcgttcccgctgcagcCgcgagttgtaggcgcgagac	5	8	15	13	6	0	1	0	0	0	1	2	3	1	1	2	2	2	6	2	2	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:2426974C>A	uc002lvx.1	-	3	604	c.260G>T	c.(259-261)CGG>CTG	p.R87L		NM_012458	NP_036590	Q9Y5L4	TIM13_HUMAN	translocase of inner mitochondrial membrane 13	87					protein import into mitochondrial inner membrane|sensory perception of sound|transmembrane transport	mitochondrial inner membrane presequence translocase complex|mitochondrial intermembrane space protein transporter complex	protein binding|zinc ion binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGCTGCAGCCGCGAGTTGTA	0.647													9	12					0.00829132	0.00835725	1	0	A	2426974	A	A	2426974	3	1	29	1	0	0	0	0	1	0	0	0	15972	652	23	3	31	3	TIMM13	19	2426974	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	626973	2426974	56702009	387	5921											
UHRF1	29128	broad.mit.edu	37	chr19	4910983	4910983	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaccaaggtggaggagctgaGgcggaagatccaggagctgt	11	5	18	7	1	0	2	0	1	0	1	1	7	1	6	2	6	2	2	2	6	2	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:4910983G>A	uc002mbo.2	+	2	254	c.86G>A	c.(85-87)AGG>AAG	p.R29K	uc002mbn.1_5'Flank|UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.R42K	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	29	Ubiquitin-like.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		GAGGAGCTGAGGCGGAAGATC	0.627											OREG0025176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	60	127					0	0	0	0	A	4910983	A	A	4910983	3	1	29	1	0	0	0	0	1	0	0	0	17035	1000	35	4	127	4	UHRF1	19	4910983	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2484009	4910983	54218000	388	5922											
MUC16	94025	broad.mit.edu	37	chr19	9002556	9002556	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcccagctcagtgatgccGtgggtcagctggctcagctt	5	9	15	12	1	3	1	3	1	0	0	3	1	3	1	2	3	4	4	2	3	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:9002556G>A	uc002mkp.2	-	51	40464	c.40260C>T	c.(40258-40260)CAC>CAT	p.H13420H	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.H237H|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13422	Extracellular (Potential).|SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGTGATGCCGTGGGTCAGCT	0.582													88	215					0	0	0	0	A	9002556	A	A	9002556	2	1	29	1	0	0	0	0	0	0	0	1	10026	1136	40	1		1	MUC16	19	9002556	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	4091573	9002556	50126427	389	5923											
MUC16	94025	broad.mit.edu	37	chr19	9060524	9060524	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagaaacaatgtcttttatGgtggaagaggtgaccactgg	12	11	13	5	0	1	3	0	1	1	2	1	4	1	4	1	4	1	1	1	4	5	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:9060524G>A	uc002mkp.2	-	3	27126	c.26922C>T	c.(26920-26922)ACC>ACT	p.T8974T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8976	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTCTTTTATGGTGGAAGAGG	0.488													74	180					0	0	0	0	A	9060524	A	A	9060524	2	1	29	1	0	0	0	0	0	0	0	1	10026	1335	47	4		4	MUC16	19	9060524	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	57968	9060524	50068459	390	5924											
SMARCA4	6597	broad.mit.edu	37	chr19	11144071	11144071	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagaagatcctagctgcaGccaagtacaagctcaacgtg	14	6	11	10	1	1	2	1	0	0	2	2	3	2	2	2	1	6	4	2	1	6	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:11144071G>A	uc002mqf.3	+	26	3936	c.3652G>A	c.(3652-3654)GCC>ACC	p.A1218T	SMARCA4_uc010dxp.2_Missense_Mutation_p.A1218T|SMARCA4_uc010dxo.2_Missense_Mutation_p.A1218T|SMARCA4_uc010dxq.2_Missense_Mutation_p.A1218T|SMARCA4_uc010dxr.2_Missense_Mutation_p.A1218T|SMARCA4_uc002mqj.3_Missense_Mutation_p.A1218T|SMARCA4_uc010dxs.2_Missense_Mutation_p.A1218T|SMARCA4_uc010dxt.1_Missense_Mutation_p.A438T|SMARCA4_uc002mqh.3_Missense_Mutation_p.A341T|SMARCA4_uc002mqi.1_Missense_Mutation_p.A421T	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1218	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CCTAGCTGCAGCCAAGTACAA	0.632			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				87	206					0	0	0	0	A	11144071	A	A	11144071	3	1	29	1	0	0	0	0	1	0	0	0	14834	971	34	4	3750	4	SMARCA4	19	11144071	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2083547	11144071	47984912	391	5925											
RAB3D	9545	broad.mit.edu	37	chr19	11436084	11436084	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggccatctctagcagctgCagctgctgggctggggggct	4	8	18	11	0	1	0	0	0	1	0	2	0	1	0	1	6	5	7	1	6	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:11436084C>A	uc002mqy.2	-	5	888	c.650G>T	c.(649-651)TGC>TTC	p.C217F	TSPAN16_uc002mqv.1_Intron|RAB3D_uc002mqx.2_5'Flank	NM_004283	NP_004274	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	217					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(2)	2						CTAGCAGCTGCAGCTGCTGGG	0.657													10	5					2.17888e-05	2.27771e-05	1	0	A	11436084	A	A	11436084	3	1	29	1	0	0	0	0	1	0	0	0	12999	710	25	4	13	4	RAB3D	19	11436084	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	292013	11436084	47692899	392	5926											
ECSIT	51295	broad.mit.edu	37	chr19	11624045	11624045	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatggggtagcttttgcgTccaaagatctgaatcagcag	11	10	12	8	1	2	2	1	1	1	1	3	2	3	2	1	2	4	4	1	2	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:11624045T>C	uc002msb.2	-	4	698	c.564A>G	c.(562-564)GGA>GGG	p.G188G	ECSIT_uc002msa.1_RNA|ECSIT_uc010dyc.1_Silent_p.G188G|ECSIT_uc010dyd.2_Silent_p.G188G|ECSIT_uc010xma.1_Intron	NM_016581	NP_057665	Q9BQ95	ECSIT_HUMAN	evolutionarily conserved signaling intermediate	188					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			ovary(1)	1						AGCTTTTGCGTCCAAAGATCT	0.587													22	29					0	0	0	0	C	11624045	C	C	11624045	2	2	29	1	0	0	0	0	0	0	0	1	4922	1654	58	5		5	ECSIT	19	11624045	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	187961	11624045	47504938	393	5927											
FBXW9	84261	broad.mit.edu	37	chr19	12800869	12800869	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgtgccggtcatccgccagCagggtcagcacgggtctgga	7	7	15	12	3	3	0	2	0	1	0	4	1	4	1	3	4	3	2	3	4	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:12800869C>T	uc010dyx.2	-	6	999	c.999G>A	c.(997-999)CTG>CTA	p.L333L	FBXW9_uc010xmp.1_RNA|uc002mul.1_3'UTR|FBXW9_uc002mum.1_Silent_p.L313L|FBXW9_uc002mun.1_Silent_p.L150L	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	343	WD 4.						protein binding			ovary(1)	1						CATCCGCCAGCAGGGTCAGCA	0.657													65	138					0	0	0	0	T	12800869	T	T	12800869	2	4	29	1	0	0	0	0	0	0	0	1	5803	697	25	4		4	FBXW9	19	12800869	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1176824	12800869	46328114	394	5928											
ILVBL	10994	broad.mit.edu	37	chr19	15234374	15234374	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctccgccatgccggacgCttgccttgtccacctgggcc	3	10	10	18	3	1	0	0	0	1	0	4	1	3	1	7	2	2	1	7	2	0	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:15234374C>A	uc002nam.2	-	3	270	c.149G>T	c.(148-150)AGC>ATC	p.S50I	ILVBL_uc010dzw.2_5'UTR|ILVBL_uc010dzx.1_Missense_Mutation_p.S50I	NM_006844	NP_006835	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	50						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			ovary(2)	2						ATGCCGGACGCTTGCCTTGTC	0.632													26	71					2.4375e-19	3.08182e-19	1	0	A	15234374	A	A	15234374	3	1	29	1	0	0	0	0	1	0	0	0	7754	797	28	4	1805	4	ILVBL	19	15234374	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2433505	15234374	43894609	395	5929											
NOTCH3	4854	broad.mit.edu	37	chr19	15290995	15290995	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccagtacggccctctgggCacacgcagtagtgggagctg	8	7	14	12	2	1	0	0	0	1	0	1	1	1	1	2	3	3	5	2	3	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:15290995C>A	uc002nan.2	-	20	3291	c.3215G>T	c.(3214-3216)TGC>TTC	p.C1072F	NOTCH3_uc002nao.1_Missense_Mutation_p.C1020F	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1072	Extracellular (Potential).|EGF-like 27.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GCCCTCTGGGCACACGCAGTA	0.652													54	106					7.77372e-23	1.01058e-22	1	0	A	15290995	A	A	15290995	3	1	29	1	0	0	0	0	1	0	0	0	10604	710	25	4	3806	4	NOTCH3	19	15290995	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	56621	15290995	43837988	396	5930											
WIZ	58525	broad.mit.edu	37	chr19	15547905	15547905	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccccgcagaagtcacagcGcatcaggctgaaggtgcctg	10	5	13	13	2	2	2	2	1	0	1	2	2	2	2	3	2	3	3	3	2	2	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:15547905G>A	uc002nbb.3	-	3	455	c.241C>T	c.(241-243)CGC>TGC	p.R81C		NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						nucleus	zinc ion binding				0						AAGTCACAGCGCATCAGGCTG	0.657													5	16					0	0	0	0	A	15547905	A	A	15547905	3	1	29	1	0	0	0	0	1	0	0	0	17443	1087	38	1	2167	1	WIZ	19	15547905	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	256910	15547905	43581078	397	5931											
KCNN1	3780	broad.mit.edu	37	chr19	18085010	18085010	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctcttcgagaagcggaagCgcctcagcgactatgccctc	8	7	11	15	5	2	1	1	0	1	1	4	4	2	2	2	1	4	1	2	1	3	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:18085010C>A	uc002nht.2	+	3	623	c.313C>A	c.(313-315)CGC>AGC	p.R105S	KCNN1_uc010xqa.1_Missense_Mutation_p.R105S	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	105					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						GAAGCGGAAGCGCCTCAGCGA	0.627													13	20					9.31168e-06	9.77437e-06	1	0	A	18085010	A	A	18085010	3	1	29	1	0	0	0	0	1	0	0	0	8117	768	27	3	315	3	KCNN1	19	18085010	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2537105	18085010	41043973	398	5932											
GATAD2A	54815	broad.mit.edu	37	chr19	19606652	19606652	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcgaagctggggccacaggcGagctcacaggtcgtcatgcc	8	6	14	13	3	2	0	2	0	0	0	4	2	2	0	2	4	3	2	2	4	1	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:19606652G>C	uc010xqt.1	+	6	1026	c.714G>C	c.(712-714)GCG>GCC	p.A238A	GATAD2A_uc010xqu.1_Intron|GATAD2A_uc010xqv.1_Silent_p.A257A|GATAD2A_uc010xqw.1_Silent_p.A65A	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	238					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGCCACAGGCGAGCTCACAGG	0.657													25	32					0	0	0	0	C	19606652	C	C	19606652	2	2	29	1	0	0	0	0	0	0	0	1	6295	1045	37	3		3	GATAD2A	19	19606652	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1521642	19606652	39522331	399	5933											
GPATCH1	55094	broad.mit.edu	37	chr19	33585111	33585111	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcgaattgctaagaaaaatGggttggaaagaaggacaagg	17	8	13	3	1	0	2	0	0	0	2	1	5	0	4	0	4	1	2	0	4	7	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:33585111G>T	uc002nug.1	+	5	803	c.489G>T	c.(487-489)ATG>ATT	p.M163I		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	163	G-patch.					catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					TAAGAAAAATGGGTTGGAAAG	0.383													27	45					2.08457e-15	2.54057e-15	1	0	T	33585111	T	T	33585111	3	4	29	1	0	0	0	0	1	0	0	0	6628	1348	47	4	507	4	GPATCH1	19	33585111	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	13978459	33585111	25543872	400	5934											
WTIP	126374	broad.mit.edu	37	chr19	34991064	34991064	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgcagctgagcggggaggagGgacgccgttgctatcccctg	6	7	17	11	3	0	1	0	1	0	0	1	4	1	4	3	4	4	4	3	4	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:34991064G>A	uc002nvm.2	+	8	1183	c.1183G>A	c.(1183-1185)GGA>AGA	p.G395R		NM_001080436	NP_001073905			Wilms tumor 1 interacting protein												0	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			CGGGGAGGAGGGACGCCGTTG	0.672													15	35					0	0	0	0	A	34991064	A	A	34991064	3	1	29	1	0	0	0	0	1	0	0	0	17478	1233	43	4	1213	4	WTIP	19	34991064	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1405953	34991064	24137919	401	5935											
FFAR2	2867	broad.mit.edu	37	chr19	35940898	35940898	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcttctacagcagcatctaCtgcagcacgtggctcctggc	7	9	11	14	1	2	0	0	0	2	0	3	0	3	0	1	3	6	6	1	3	2	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:35940898C>A	uc002nzg.2	+	2	362	c.282C>A	c.(280-282)TAC>TAA	p.Y94*	FFAR2_uc010eea.2_Nonsense_Mutation_p.Y94*	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	94	Helical; Name=3; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCAGCATCTACTGCAGCACGT	0.607													17	22					3.52763e-06	3.73384e-06	1	0	A	35940898	A	A	35940898	4	1	29	1	0	0	0	0	0	1	0	0	5860	576	20	4	284	4	FFAR2	19	35940898	Nonsense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	949834	35940898	23188085	402	5936											
ZNF607	84775	broad.mit.edu	37	chr19	38189043	38189043	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccagtatgaactctatgAtgtatactaagttcatggct	12	14	7	8	0	3	2	2	2	1	0	3	2	3	2	1	1	2	4	1	1	6	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:38189043A>G	uc002ohc.1	-	5	2585	c.1989T>C	c.(1987-1989)CAT>CAC	p.H663H	ZNF607_uc002ohb.1_Silent_p.H662H	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	663	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			GAACTCTATGATGTATACTAA	0.363													50	73					0	0	0	0	G	38189043	G	G	38189043	2	3	29	1	0	0	0	0	0	0	0	1	18100	330	12	5		5	ZNF607	19	38189043	Silent	SNP	A	TCGA-BB-7862-01A-21D-2229-08	2248145	38189043	20939940	403	5937											
CEACAM7	1087	broad.mit.edu	37	chr19	42181430	42181430	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacttgcttgtactgactcAtctgccatggaaagaaaaga	14	10	9	8	0	2	3	1	1	1	2	2	5	2	4	1	1	4	2	1	1	5	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:42181430A>T	uc002ori.1	-	4	710	c.708T>A	c.(706-708)TAT>TAA	p.Y236*	CEACAM7_uc010ehx.2_Nonsense_Mutation_p.Y236*|CEACAM7_uc010ehy.1_Nonsense_Mutation_p.Y143*	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	236						anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		GTACTGACTCATCTGCCATGG	0.473													42	21					0	0	0	0	T	42181430	T	T	42181430	4	4	29	1	0	0	0	0	0	1	0	0	3212	231	8	5	93	5	CEACAM7	19	42181430	Nonsense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	3992387	42181430	16947553	404	5938											
CEACAM8	1088	broad.mit.edu	37	chr19	43093044	43093044	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtgatgttggggataaagaGcttttgtgtgtattgctgga	9	15	15	2	0	0	2	0	1	0	1	0	4	0	4	0	3	2	4	0	3	3	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:43093044G>A	uc002oud.2	-	4	952	c.850C>T	c.(850-852)CTC>TTC	p.L284F	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	284	Ig-like C2-type 2.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				GGGATAAAGAGCTTTTGTGTG	0.507													24	20					0	0	0	0	A	43093044	A	A	43093044	3	1	29	1	0	0	0	0	1	0	0	0	3213	971	34	4	207	4	CEACAM8	19	43093044	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	911614	43093044	16035939	405	5939											
MARK4	57787	broad.mit.edu	37	chr19	45790802	45790802	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgccaggccggaaggcgagCtgcagcaccgcggggagtgg	7	3	19	12	4	0	0	0	0	0	0	0	3	0	2	3	6	4	3	3	6	1	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:45790802C>T	uc002pbb.1	+	13	1379	c.1374C>T	c.(1372-1374)AGC>AGT	p.S458S	MARK4_uc002pba.1_Silent_p.S458S|MARK4_uc002pbc.1_Silent_p.S324S			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	458					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGAAGGCGAGCTGCAGCACCG	0.716													6	6					0	0	0	0	T	45790802	T	T	45790802	2	4	29	1	0	0	0	0	0	0	0	1	9368	796	28	4		4	MARK4	19	45790802	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2697758	45790802	13338181	406	5940											
SIX5	147912	broad.mit.edu	37	chr19	46269000	46269000	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaccagacaggcacggccGcgggtgacaacatcagcccc	10	3	12	16	3	1	3	1	2	0	1	1	3	1	3	4	3	2	1	4	3	1	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:46269000G>T	uc002pdb.2	-	3	2374	c.1979C>A	c.(1978-1980)GCG>GAG	p.A660E	SIX5_uc002pdc.2_3'UTR	NM_175875	NP_787071	Q8N196	SIX5_HUMAN	SIX homeobox 5	660						cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00783)|GBM - Glioblastoma multiforme(486;0.0802)|Epithelial(262;0.235)		AGGCACGGCCGCGGGTGACAA	0.687													12	53					7.05477e-17	8.76658e-17	1	0	T	46269000	T	T	46269000	3	4	29	1	0	0	0	0	1	0	0	0	14415	1087	38	3	244	3	SIX5	19	46269000	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	478198	46269000	12859983	407	5941											
LILRB5	10990	broad.mit.edu	37	chr19	54760627	54760627	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagcccagagggtgggtttgGggagggtgcctagaatggaa	9	7	19	6	0	0	2	0	0	0	2	0	4	0	4	2	6	2	1	2	6	3	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:54760627G>T	uc002qex.2	-	3	191	c.80C>A	c.(79-81)CCC>CAC	p.P27H	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.P27H|LILRB5_uc002qey.2_Missense_Mutation_p.P27H|LILRB5_uc002qez.2_Missense_Mutation_p.P27H|LILRB5_uc002qfa.1_Missense_Mutation_p.P17H|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	27	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGTGGGTTTGGGGAGGGTGCC	0.622													39	28					8.69298e-16	1.06457e-15	1	0	T	54760627	T	T	54760627	3	4	29	1	0	0	0	0	1	0	0	0	8835	1232	43	4	1739	4	LILRB5	19	54760627	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	8491627	54760627	4368356	408	5942											
KIR3DL2	3812	broad.mit.edu	37	chr19	55363640	55363640	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcatcatgggccctgtgacCccagcacatgcagggaccta	9	8	10	14	0	2	1	2	1	0	0	2	2	2	2	4	2	2	2	4	2	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:55363640C>A	uc002qho.3	+	3	291	c.258C>A	c.(256-258)ACC>ACA	p.T86T	KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc002qhn.1_Intron|KIR3DL2_uc010esh.2_Silent_p.T86T	NM_006737	NP_006728	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three	86	Extracellular (Potential).|Ig-like C2-type 1.				cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0192)		GCCCTGTGACCCCAGCACATG	0.557													26	9					3.54909e-21	4.55541e-21	1	0	A	55363640	A	A	55363640	2	1	29	1	0	0	0	0	0	0	0	1	8360	610	22	4		4	KIR3DL2	19	55363640	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	603013	55363640	3765343	409	5943											
ZNF548	147694	broad.mit.edu	37	chr19	57910317	57910317	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcaccagaaaatccacacagGagaaaggtcttatgaatgta	17	7	9	8	0	1	3	0	1	1	2	2	4	2	3	2	2	0	2	2	2	6	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr19:57910317G>T	uc002qom.2	+	3	912	c.662G>T	c.(661-663)GGA>GTA	p.G221V	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.G224V	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATCCACACAGGAGAAAGGTCT	0.383													23	28					1.75199e-13	2.06571e-13	1	0	T	57910317	T	T	57910317	3	4	29	1	0	0	0	0	1	0	0	0	18047	1174	41	2	712	2	ZNF548	19	57910317	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2546677	57910317	1218666	410	5944											
PLCB4	5332	broad.mit.edu	37	chr20	9434014	9434014	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaacacagtaccatgcagaaGttacactgcacgcaagttga	15	7	9	10	1	0	2	0	1	0	1	0	3	0	2	1	0	5	6	1	0	5	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr20:9434014G>A	uc002wnf.2	+	31	3001	c.2865G>A	c.(2863-2865)AAG>AAA	p.K955K	PLCB4_uc010gbw.1_Silent_p.K955K|PLCB4_uc010gbx.2_Silent_p.K967K|PLCB4_uc002wne.2_Silent_p.K955K|PLCB4_uc002wnh.2_Silent_p.K802K	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	955					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CCATGCAGAAGTTACACTGCA	0.428													41	58					0	0	0	0	A	9434014	A	A	9434014	2	1	29	1	0	0	0	0	0	0	0	1	12085	1020	36	4		4	PLCB4	20	9434014	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08		9434014	53591506	411	5945											
GDAP1L1	78997	broad.mit.edu	37	chr20	42885925	42885925	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcccgtcatcatccaccgcGacaacatcatcagtgactat	11	9	6	15	3	4	1	4	1	0	0	5	2	5	1	3	0	2	0	3	0	2	1	rs149151812		TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr20:42885925G>A	uc002xlq.2	+	2	380	c.313G>A	c.(313-315)GAC>AAC	p.D105N	GDAP1L1_uc002xlp.1_Missense_Mutation_p.D105N|GDAP1L1_uc010zwl.1_Missense_Mutation_p.D105N|GDAP1L1_uc010zwm.1_Missense_Mutation_p.D105N|GDAP1L1_uc010zwn.1_Intron	NM_024034	NP_076939	Q96MZ0	GD1L1_HUMAN	ganglioside-induced differentiation-associated	105	GST N-terminal.									large_intestine(1)	1		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CATCCACCGCGACAACATCAT	0.617													18	48					0	0	0	0	A	42885925	A	A	42885925	3	1	29	1	0	0	0	0	1	0	0	0	6344	1058	37	1	319	1	GDAP1L1	20	42885925	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	33451911	42885925	20139595	412	5946											
MMP9	4318	broad.mit.edu	37	chr20	44641955	44641955	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acaccgcagcccacggctccCccgacggtctgccccaccgg	6	3	10	22	5	1	0	0	0	1	0	2	1	2	0	7	3	2	2	7	3	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr20:44641955C>A	uc002xqz.2	+	9	1411	c.1392C>A	c.(1390-1392)CCC>CCA	p.P464P		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	464					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CCACGGCTCCCCCGACGGTCT	0.483											OREG0025990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	76	147					6.11987e-43	8.50075e-43	1	0	A	44641955	A	A	44641955	2	1	29	1	0	0	0	0	0	0	0	1	9722	610	22	4		4	MMP9	20	44641955	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1756030	44641955	18383565	413	5947											
PREX1	57580	broad.mit.edu	37	chr20	47248859	47248859	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actttctccagggactgcgcGttgatgtcctgctgcaaatc	7	12	10	12	2	1	1	0	1	1	0	4	2	2	2	2	1	3	3	2	1	1	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr20:47248859G>T	uc002xtw.1	-	35	4505	c.4482C>A	c.(4480-4482)AAC>AAA	p.N1494K	PREX1_uc002xtv.1_Missense_Mutation_p.N791K	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1494					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GGGACTGCGCGTTGATGTCCT	0.637													102	212					2.3733e-33	3.22591e-33	1	0	T	47248859	T	T	47248859	3	4	29	1	0	0	0	0	1	0	0	0	12538	1136	40	3	521	3	PREX1	20	47248859	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2606904	47248859	15776661	414	5948											
TMEM189-UBE2V1	387522	broad.mit.edu	37	chr20	48713232	48713232	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggcccaattatcatccCtgtccatcttgtaagtgtca	9	13	8	11	0	3	0	2	0	1	0	5	1	5	1	3	2	0	1	3	2	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr20:48713232C>T	uc002xvf.2	-	6	978	c.817G>A	c.(817-819)GGG>AGG	p.G273R	UBE2V1_uc002xvb.2_Intron|UBE2V1_uc002xva.2_Missense_Mutation_p.G50R|UBE2V1_uc002xvc.2_Intron|UBE2V1_uc002xvd.2_Missense_Mutation_p.G73R|UBE2V1_uc002xve.2_Missense_Mutation_p.G73R	NM_199203	NP_954673	Q13404	UB2V1_HUMAN	TMEM189-UBE2V1 readthrough transcript	50					cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein K63-linked ubiquitination|regulation of DNA repair|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-UEV1A complex|ubiquitin ligase complex	acid-amino acid ligase activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(9;8.29e-07)			ATTATCATCCCTGTCCATCTT	0.433													59	108					0	0	0	0	T	48713232	T	T	48713232	3	4	29	1	0	0	0	0	1	0	0	0	16178	681	24	4	307	4	TMEM189-UBE2V1	20	48713232	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1464373	48713232	14312288	415	5949											
ATP9A	10079	broad.mit.edu	37	chr20	50346510	50346510	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgcagcatctcagccactCgcagcacctgtgggaaagaa	12	5	10	14	2	1	1	1	0	1	1	3	2	1	2	3	1	3	4	3	1	2	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr20:50346510C>A	uc002xwg.1	-	2	76	c.76G>T	c.(76-78)GAG>TAG	p.E26*	ATP9A_uc010gih.1_Nonsense_Mutation_p.E11*	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	26	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						CTCAGCCACTCGCAGCACCTG	0.602													37	128					7.05121e-23	9.19014e-23	1	0	A	50346510	A	A	50346510	4	1	29	1	0	0	0	0	0	1	0	0	1200	893	31	3	3175	3	ATP9A	20	50346510	Nonsense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	1633278	50346510	12679010	416	5950											
OGFR	11054	broad.mit.edu	37	chr20	61438939	61438939	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gccacgagggacatgtgtagGtatcggcacaactatccggt	10	8	13	10	3	0	0	0	0	0	0	2	2	1	1	2	4	1	3	2	4	4	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr20:61438939G>T	uc002ydj.2	+	2	257	c.222G>T	c.(220-222)AGG>AGT	p.R74S	OGFR_uc002ydk.2_Missense_Mutation_p.R57S|OGFR_uc002ydl.2_5'UTR	NM_007346	NP_031372	Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	74				DAGDEDEESEEPRAARPSSFQSRMTGSRNWRATRDMCRYRH NYP -> GARRALGVLGQPGGLQMRLPERHGGPQGSLCLMD PCCPLSLALQ (in Ref. 5).	regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity				0	Breast(26;3.65e-08)					ACATGTGTAGGTATCGGCACA	0.582													17	32					1.10923e-09	1.23872e-09	1	0	T	61438939	T	T	61438939	3	4	29	1	0	0	0	0	1	0	0	0	10897	1252	44	4	228	4	OGFR	20	61438939	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	11092429	61438939	1586581	417	5951											
DIDO1	11083	broad.mit.edu	37	chr20	61528097	61528097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgctgcaggtgccggtccggCctgcctggcagctgaagcac	5	6	15	15	3	0	1	0	1	0	0	1	1	1	1	4	4	5	5	4	4	1	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr20:61528097C>T	uc002ydr.1	-	7	2104	c.1840G>A	c.(1840-1842)GCC>ACC	p.A614T	DIDO1_uc002yds.1_Missense_Mutation_p.A614T|DIDO1_uc002ydt.1_Missense_Mutation_p.A614T|DIDO1_uc002ydu.1_Missense_Mutation_p.A614T	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	614					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GCCGGTCCGGCCTGCCTGGCA	0.617													24	90					0	0	0	0	T	61528097	T	T	61528097	3	4	29	1	0	0	0	0	1	0	0	0	4544	739	26	4	4951	4	DIDO1	20	61528097	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	89158	61528097	1497423	418	5952											
HSPA13	6782	broad.mit.edu	37	chr21	15753648	15753648	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagctctacgctttcatatCccacatatacatcattgtca	11	13	3	14	1	4	0	3	0	1	0	5	0	5	0	2	0	3	2	2	0	4	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr21:15753648C>A	uc002yjt.2	-	2	311	c.242G>T	c.(241-243)GGA>GTA	p.G81V	HSPA13_uc011abx.1_5'UTR	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	81						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						GCTTTCATATCCCACATATAC	0.398													43	30					6.33695e-27	8.36675e-27	1	0	A	15753648	A	A	15753648	3	1	29	1	0	0	0	0	1	0	0	0	7445	855	30	2	1189	2	HSPA13	21	15753648	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08		15753648	32376247	419	5953											
COL18A1	80781	broad.mit.edu	37	chr21	46912604	46912604	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtccctctttccccagggcCggccgggtttcgcaggcttt	2	11	12	16	4	1	0	0	0	1	0	4	0	3	0	5	4	0	3	5	4	0	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr21:46912604C>G	uc011afs.1	+	23	3457	c.3436C>G	c.(3436-3438)CGG>GGG	p.R1146G	COL18A1_uc002zhg.2_Missense_Mutation_p.R731G|COL18A1_uc002zhi.2_Missense_Mutation_p.R911G	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1146	Triple-helical region 5 (COL5).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		TCCCCAGGGCCGGCCGGGTTT	0.701													32	39					0	0	0	0	G	46912604	G	G	46912604	3	3	29	1	0	0	0	0	1	0	0	0	3690	643	23	3	3640	3	COL18A1	21	46912604	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	31158956	46912604	1217291	420	5954											
P2RX6	9127	broad.mit.edu	37	chr22	21372348	21372348	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcagggcagatgcccagAggtgagtttacccaggatcc	10	8	13	10	0	1	3	1	1	0	2	2	4	2	4	3	3	2	3	3	3	1	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr22:21372348A>T	uc010gsu.1	+	3	386	c.386A>T	c.(385-387)GAG>GTG	p.E129V	P2RX6_uc002ztz.2_Missense_Mutation_p.E103V|P2RX6_uc010gst.1_3'UTR|P2RX6_uc002zua.2_Intron|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	129	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						AGATGCCCAGAGGTGAGTTTA	0.602													8	17					0	0	0	0	T	21372348	T	T	21372348	3	4	29	1	0	0	0	0	1	0	0	0	11398	318	11	5	396	5	P2RX6	22	21372348	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08		21372348	29932218	421	5955											
CCDC116	164592	broad.mit.edu	37	chr22	21991274	21991274	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacatggacaatgagggccGtgataaagccgagattgaag	14	6	15	6	2	0	4	0	3	0	1	0	7	0	6	2	3	1	0	2	3	4	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr22:21991274G>A	uc002zve.2	+	5	1850	c.1757G>A	c.(1756-1758)CGT>CAT	p.R586H		NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	Error:Variant_position_missing_in_Q8IYX3_after_alignment										ovary(1)|skin(1)	2	Colorectal(54;0.105)					AATGAGGGCCGTGATAAAGCC	0.443													45	57					0	0	0	0	A	21991274	A	A	21991274	3	1	29	1	0	0	0	0	1	0	0	0	2765	1145	40	1	1771	1	CCDC116	22	21991274	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	618926	21991274	29313292	422	5956											
AP1B1	162	broad.mit.edu	37	chr22	29754923	29754923	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagcccatggtccgcactGccagggctcggatgaggggg	6	6	17	12	2	0	1	0	1	0	0	2	2	1	2	3	5	3	3	3	5	0	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr22:29754923G>T	uc003afj.2	-	5	501	c.317C>A	c.(316-318)GCA>GAA	p.A106E	AP1B1_uc003afi.2_Missense_Mutation_p.A106E|AP1B1_uc003afk.2_Missense_Mutation_p.A106E|AP1B1_uc003afl.2_Missense_Mutation_p.A106E	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	106					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GGTCCGCACTGCCAGGGCTCG	0.612													18	17					1.55795e-14	1.87175e-14	1	0	T	29754923	T	T	29754923	3	4	29	1	0	0	0	0	1	0	0	0	731	1319	46	4	2608	4	AP1B1	22	29754923	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	7763649	29754923	21549643	423	5957											
DEPDC5	9681	broad.mit.edu	37	chr22	32241081	32241081	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccgccaccaagcgcatcaCggagggggaggcccactgcg	9	2	14	16	4	1	0	1	0	0	0	1	2	1	2	4	4	2	1	4	4	1	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chr22:32241081C>T	uc003als.2	+	30	2994	c.2852C>T	c.(2851-2853)ACG>ATG	p.T951M	DEPDC5_uc011als.1_Missense_Mutation_p.T882M|DEPDC5_uc011alu.1_Missense_Mutation_p.T960M|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.T951M|DEPDC5_uc003alu.2_Missense_Mutation_p.T400M|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Missense_Mutation_p.T281M|DEPDC5_uc003alw.2_Missense_Mutation_p.T249M|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_Translation_Start_Site	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	951					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						AAGCGCATCACGGAGGGGGAG	0.602													38	86					0	0	0	0	T	32241081	T	T	32241081	3	4	29	1	0	0	0	0	1	0	0	0	4464	536	19	1	2984	1	DEPDC5	22	32241081	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	2486158	32241081	19063485	424	5958											
PNPLA4	8228	broad.mit.edu	37	chrX	7870155	7870155	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacgggcaggatgggaagagCgttggtgaggcctccgtcca	8	6	18	9	3	0	2	0	1	0	1	2	5	2	4	3	5	1	2	3	5	1	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:7870155C>A	uc011mhq.1	-	6	667	c.505G>T	c.(505-507)GCT>TCT	p.A169S	PNPLA4_uc011mhr.1_Missense_Mutation_p.A169S|PNPLA4_uc011mhs.1_Missense_Mutation_p.A82S	NM_004650	NP_004641	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	169	Patatin.				lipid catabolic process		triglyceride lipase activity				0		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				ATGGGAAGAGCGTTGGTGAGG	0.537													24	8					1.42536e-11	1.63867e-11	1	0	A	7870155	A	A	7870155	3	1	29	1	0	0	0	0	1	0	0	0	12222	768	27	3	264	3	PNPLA4	23	7870155	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08		7870155	147400405	425	5959											
EGFL6	25975	broad.mit.edu	37	chrX	13612977	13612977	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acatgcgaacctggatgtaaGtttggtgagtgcgtgggacc	9	10	15	7	2	0	1	0	1	0	0	0	4	0	3	2	3	3	2	2	3	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:13612977G>T	uc004cvi.2	+	3	450	c.210G>T	c.(208-210)AAG>AAT	p.K70N	EGFL6_uc004cvj.2_Missense_Mutation_p.K70N|EGFL6_uc011mik.1_5'UTR	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	70	EGF-like 1.				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						CTGGATGTAAGTTTGGTGAGT	0.458													22	17					1.75199e-13	2.06571e-13	1	0	T	13612977	T	T	13612977	3	4	29	1	0	0	0	0	1	0	0	0	4985	1020	36	4	220	4	EGFL6	23	13612977	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	5742822	13612977	141657583	426	5960											
KLHL34	257240	broad.mit.edu	37	chrX	21675294	21675294	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcagttgtgggctcctgccGcaaccaagctaacgccaggc	8	7	11	15	2	1	0	1	0	0	0	2	0	2	0	4	2	4	4	4	2	3	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:21675294G>C	uc004czz.1	-	1	1155	c.613C>G	c.(613-615)CGG>GGG	p.R205G		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	205	BACK.									ovary(1)	1						GGCTCCTGCCGCAACCAAGCT	0.672													6	3					0	0	0	0	C	21675294	C	C	21675294	3	2	29	1	0	0	0	0	1	0	0	0	8426	1086	38	3	1325	3	KLHL34	23	21675294	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	8062317	21675294	133595266	427	5961											
FAM48B1	100130302	broad.mit.edu	37	chrX	24382859	24382859	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	actaccagatgcaaggcccgGtgcagtgcaggcatcttctc	9	8	11	13	1	2	1	0	0	2	1	3	1	2	1	2	3	4	4	2	3	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:24382859G>A	uc011mjx.1	+	1	1982	c.1982G>A	c.(1981-1983)GGT>GAT	p.G661D		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						GCAAGGCCCGGTGCAGTGCAG	0.617													35	15					0	0	0	0	A	24382859	A	A	24382859	3	1	29	1	0	0	0	0	1	0	0	0	5605	1261	44	4	1984	4	FAM48B1	23	24382859	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	2707565	24382859	130887701	428	5962											
MAGEB6	158809	broad.mit.edu	37	chrX	26212046	26212047	+	Missense_Mutation	DNP	CC	AT	AT																															gccacagggtctcacgggtcCccaggccactgcagagaagc																										TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:26212046_26212047CC>AT	uc004dbr.2	+	2	232_233	c.83_84CC>AT	c.(82-84)CCC>CAT	p.P28H	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	28										ovary(3)	3						CTCACGGGTCCCCAGGCCACTG	0.569													17	9					0	0	0	0	AT	26212047	AT	AT	26212046	3	1	29	1	0	0	0	0	1	0	0	0	9232	623	22	4	85	4	MAGEB6	23	26212046	Missense_Mutation	DNP	CC	TCGA-BB-7862-01A-21D-2229-08	1829187	26212046	129058514	429	5963											
FAM47C	442444	broad.mit.edu	37	chrX	37028613	37028613	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccagagcctcccaagactcgGgtgtccagtctccacgcgga	8	6	11	16	3	1	2	0	0	1	2	5	3	3	3	5	2	1	0	5	2	1	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:37028613G>C	uc004ddl.1	+	1	2144	c.2130G>C	c.(2128-2130)CGG>CGC	p.R710R		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	710										ovary(3)	3						CCAAGACTCGGGTGTCCAGTC	0.637													38	22					0	0	0	0	C	37028613	C	C	37028613	2	2	29	1	0	0	0	0	0	0	0	1	5603	1219	43	4		4	FAM47C	23	37028613	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	10816567	37028613	118241947	430	5964											
USP9X	8239	broad.mit.edu	37	chrX	41026734	41026734	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttttatcattttgaaaccaGgtcgtgattcagagtaatga	12	15	8	6	1	2	4	2	3	0	1	3	4	2	4	1	1	1	1	1	1	3	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:41026734G>A	uc004dfb.2	+	17	2962	c.2329_splice	c.e17-1	p.V777_splice	USP9X_uc004dfc.2_Splice_Site_p.V777_splice	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TTTGAAACCAGGTCGTGATTC	0.353													16	8					0	0	0	0	A	41026734	A	A	41026734	5	1	29	1	0	0	0	0	0	0	1	0	17158	1014	35	4	2390	4	USP9X	23	41026734	Splice_Site	SNP	G	TCGA-BB-7862-01A-21D-2229-08	3998121	41026734	114243826	431	5965											
GATA1	2623	broad.mit.edu	37	chrX	48649532	48649532	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccatggagttccctggcCtggggtccctggggacctca	4	9	14	14	0	1	0	1	0	0	0	4	2	4	2	5	6	0	2	5	6	0	1			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:48649532C>A	uc004dkq.3	+	2	107	c.16C>A	c.(16-18)CTG>ATG	p.L6M		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	6					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.M1fs(7)|p.E2fs*444(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						GTTCCCTGGCCTGGGGTCCCT	0.567			Mis|F		megakaryoblastic leukemia of Downs Syndrome								10	8					1.08611e-07	1.18167e-07	1	0	A	48649532	A	A	48649532	3	1	29	1	0	0	0	0	1	0	0	0	6288	680	24	4	18	4	GATA1	23	48649532	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	7622798	48649532	106621028	432	5966											
FGD1	2245	broad.mit.edu	37	chrX	54475346	54475346	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgcacacacggttggagcGgttgttgtcatagacgaggc	9	9	15	8	3	1	1	1	0	0	1	1	3	1	2	0	4	2	4	0	4	1	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:54475346G>A	uc004dtg.2	-	16	3063	c.2329C>T	c.(2329-2331)CGC>TGC	p.R777C	FGD1_uc011moi.1_3'UTR	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	777	FYVE-type.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CGGTTGGAGCGGTTGTTGTCA	0.622													22	10					0	0	0	0	A	54475346	A	A	54475346	3	1	29	1	0	0	0	0	1	0	0	0	5864	1116	39	1	568	1	FGD1	23	54475346	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	5825814	54475346	100795214	433	5967											
FOXR2	139628	broad.mit.edu	37	chrX	55650163	55650163	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatggacttaaaactaaaaGactgtgaattttggtatagt	16	13	9	3	0	0	3	0	1	0	2	0	4	0	4	0	2	1	1	0	2	7	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:55650163G>T	uc004duo.2	+	1	331	c.19G>T	c.(19-21)GAC>TAC	p.D7Y		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	7					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						AAAACTAAAAGACTGTGAATT	0.458													35	12					4.62619e-21	5.92292e-21	1	0	T	55650163	T	T	55650163	3	4	29	1	0	0	0	0	1	0	0	0	6066	942	33	2	21	2	FOXR2	23	55650163	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1174817	55650163	99620397	434	5968											
AR	367	broad.mit.edu	37	chrX	66905881	66905881	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtacctgtgcgccagcagaAatgattgcactattgataaa	14	10	9	8	1	0	3	0	2	0	1	0	3	0	3	2	0	4	3	2	0	5	5			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:66905881A>T	uc004dwu.1	+	3	2913	c.1798A>T	c.(1798-1800)AAT>TAT	p.N600Y	AR_uc011mpd.1_Missense_Mutation_p.N600Y|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.N600Y|AR_uc004dwv.1_Missense_Mutation_p.N68Y	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	599	NR C4-type.|Interaction with HIPK3 (By similarity).|Nuclear receptor.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CGCCAGCAGAAATGATTGCAC	0.403									Androgen_Insensitivity_Syndrome				32	7					0	0	0	0	T	66905881	T	T	66905881	3	4	29	1	0	0	0	0	1	0	0	0	836	14	1	5	1832	5	AR	23	66905881	Missense_Mutation	SNP	A	TCGA-BB-7862-01A-21D-2229-08	11255718	66905881	88364679	435	5969											
EDA	1896	broad.mit.edu	37	chrX	68836326	68836326	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctccacctgctgacgttGtgctgctacctagagttgcg	5	11	11	14	2	0	2	0	1	0	1	1	2	1	2	4	0	5	5	4	0	2	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:68836326G>C	uc004dxs.2	+	1	416	c.174G>C	c.(172-174)TTG>TTC	p.L58F	EDA_uc004dxr.2_Missense_Mutation_p.L58F|EDA_uc011mpj.1_Missense_Mutation_p.L58F|EDA_uc004dxn.1_Missense_Mutation_p.L58F|EDA_uc004dxm.1_Missense_Mutation_p.L58F|EDA_uc004dxp.1_Missense_Mutation_p.L58F|EDA_uc004dxq.1_Missense_Mutation_p.L58F|EDA_uc004dxl.1_Missense_Mutation_p.L58F	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	58	Helical; Signal-anchor for type II membrane protein; (Potential).				cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						TGCTGACGTTGTGCTGCTACC	0.692													45	12					0	0	0	0	C	68836326	C	C	68836326	3	2	29	1	0	0	0	0	1	0	0	0	4925	1368	48	4	176	4	EDA	23	68836326	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1930445	68836326	86434234	436	5970											
ABCB7	22	broad.mit.edu	37	chrX	74289143	74289143	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caccctgacccactacctccTacaatggccactttctttcc	8	11	3	19	0	1	1	0	1	1	0	3	1	3	1	6	1	2	0	6	1	3	4			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:74289143T>A	uc004eca.2	-	11	1537	c.1512A>T	c.(1510-1512)GTA>GTT	p.V504V	ABCB7_uc004ebz.2_Silent_p.V505V|ABCB7_uc011mqn.1_Silent_p.V478V|ABCB7_uc010nls.2_Silent_p.V465V|ABCB7_uc010nlt.2_Silent_p.V464V	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	504	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						CACTACCTCCTACAATGGCCA	0.378													66	31					0	0	0	0	A	74289143	A	A	74289143	2	1	29	1	0	0	0	0	0	0	0	1	46	1509	53	5		5	ABCB7	23	74289143	Silent	SNP	T	TCGA-BB-7862-01A-21D-2229-08	5452817	74289143	80981417	437	5971											
KLHL4	56062	broad.mit.edu	37	chrX	86919784	86919784	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatgatccaaaaggtgattCatggtcaactgtggcacctc	11	11	10	9	0	2	2	2	2	0	0	4	2	3	2	2	3	1	2	2	3	4	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:86919784C>A	uc004efb.2	+	10	2128	c.1946C>A	c.(1945-1947)TCA>TAA	p.S649*	KLHL4_uc004efa.2_Nonsense_Mutation_p.S649*	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	649	Kelch 5.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AAAGGTGATTCATGGTCAACT	0.408													19	13					2.39556e-15	2.91259e-15	1	0	A	86919784	A	A	86919784	4	1	29	1	0	0	0	0	0	1	0	0	8430	838	29	2	1984	2	KLHL4	23	86919784	Nonsense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	12630641	86919784	68350776	438	5972											
PABPC5	140886	broad.mit.edu	37	chrX	90690749	90690749	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgatccggtgacccgcagccCcctgggctatgggtatgtta	6	10	13	12	2	0	2	0	2	0	0	1	2	1	2	4	3	1	4	4	3	3	3			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:90690749C>T	uc004efg.2	+	2	613	c.173C>T	c.(172-174)CCC>CTC	p.P58L	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	58	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						ACCCGCAGCCCCCTGGGCTAT	0.532													13	7					0	0	0	0	T	90690749	T	T	90690749	3	4	29	1	0	0	0	0	1	0	0	0	11421	623	22	4	175	4	PABPC5	23	90690749	Missense_Mutation	SNP	C	TCGA-BB-7862-01A-21D-2229-08	3770965	90690749	64579811	439	5973											
GUCY2F	2986	broad.mit.edu	37	chrX	108696910	108696910	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtccaggattacatattctGaaattccatttccatttgaa	12	16	5	8	0	1	2	0	2	1	0	4	3	4	3	3	1	1	0	3	1	4	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:108696910G>A	uc004eod.3	-	4	1487	c.1211C>T	c.(1210-1212)TCA>TTA	p.S404L	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	404	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TACATATTCTGAAATTCCATT	0.478													106	9					0	0	0	0	A	108696910	A	A	108696910	3	1	29	1	0	0	0	0	1	0	0	0	6937	1294	45	2	2179	2	GUCY2F	23	108696910	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	18006161	108696910	46573650	440	5974											
ZIC3	7547	broad.mit.edu	37	chrX	136649543	136649543	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacatgggagtgaacgtggcGgcccaccacgggcccggcgc	8	3	16	14	5	0	1	0	1	0	0	0	2	0	2	3	5	2	0	3	5	2	0			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:136649543G>T	uc004fak.2	+	1	1198	c.693G>T	c.(691-693)GCG>GCT	p.A231A		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	231					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TGAACGTGGCGGCCCACCACG	0.647													26	16					7.24521e-05	7.51191e-05	1	0	T	136649543	T	T	136649543	2	4	29	1	0	0	0	0	0	0	0	1	17747	1103	39	3		3	ZIC3	23	136649543	Silent	SNP	G	TCGA-BB-7862-01A-21D-2229-08	27952633	136649543	18621017	441	5975											
F9	2158	broad.mit.edu	37	chrX	138643014	138643014	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaattacagttgtcgcaGgtaaatacacagaaagaata	19	10	7	5	1	0	2	0	0	0	2	1	2	0	2	0	1	2	3	0	1	9	6			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:138643014G>T	uc004fas.1	+	7	867	c.838G>T	c.(838-840)GGT>TGT	p.G280C	F9_uc004fat.1_Missense_Mutation_p.G242C	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	280	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	AGTTGTCGCAGGTAAATACAC	0.343													51	11					2.17126e-26	2.85929e-26	1	0	T	138643014	T	T	138643014	3	4	29	1	0	0	0	0	1	0	0	0	5379	1014	35	4	864	4	F9	23	138643014	Missense_Mutation	SNP	G	TCGA-BB-7862-01A-21D-2229-08	1993471	138643014	16627546	442	5976											
PRRG3	79057	broad.mit.edu	37	chrX	150869334	150869334	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccggctagagagcaccctCtacctccctgagctctctct	6	10	8	17	1	3	2	0	1	3	1	6	3	5	2	4	1	3	3	4	1	2	2			TCGA-BB-7862-01A-21D-2229-08	TCGA-BB-7862-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	84c57a23-1428-488e-9275-9f2bc3673476	5aecc517-51d9-48af-ae2a-8eb82cc47df3	g.chrX:150869334C>A	uc004few.1	+	4	915	c.525C>A	c.(523-525)CTC>CTA	p.L175L		NM_024082	NP_076987	Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3	175	Cytoplasmic (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGCACCCTCTACCTCCCTG	0.672													22	16					1.85244e-09	2.05512e-09	1	0	A	150869334	A	A	150869334	2	1	29	1	0	0	0	0	0	0	0	1	12669	900	32	2		2	PRRG3	23	150869334	Silent	SNP	C	TCGA-BB-7862-01A-21D-2229-08	12226320	150869334	4401226	443	5977											
CLCN6	1185	broad.mit.edu	37	chr1	11883823	11883823	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatctgaatggcgtaaaggtGccaggaatcgtccgtctccg	9	10	12	10	4	2	1	0	1	2	0	5	2	3	2	3	3	1	1	3	3	5	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr1:11883823G>A	uc001ate.3	+	7	626	c.513G>A	c.(511-513)GTG>GTA	p.V171V	CLCN6_uc009vnf.1_Silent_p.V171V|CLCN6_uc009vng.1_Silent_p.V171V|CLCN6_uc009vnh.1_Silent_p.V171V|CLCN6_uc010oat.1_5'UTR|CLCN6_uc010oau.1_Silent_p.V149V	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	171					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GCGTAAAGGTGCCAGGAATCG	0.542													15	41					0	0	0	0	A	11883823	A	A	11883823	2	1	30	1	0	0	0	0	0	0	0	1	3482	1306	46	4		4	CLCN6	1	11883823	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08		11883823	237366798	1	5978											
MAP7D1	55700	broad.mit.edu	37	chr1	36644168	36644168	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcgggagcgcgaggagcaGgagcggaggctgcaggcaga	10	1	21	9	4	0	1	0	0	0	1	0	6	0	5	0	6	5	4	0	6	0	0			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr1:36644168G>A	uc001bzz.2	+	10	2073	c.1857G>A	c.(1855-1857)CAG>CAA	p.Q619Q	MAP7D1_uc001caa.2_Silent_p.Q587Q|MAP7D1_uc001cab.2_Silent_p.Q582Q|MAP7D1_uc001cac.2_Silent_p.Q319Q|MAP7D1_uc001cad.2_Silent_p.Q156Q	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	619	Potential.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				GCGAGGAGCAGGAGCGGAGGC	0.682													2	3					0	0	0	0	A	36644168	A	A	36644168	2	1	30	1	0	0	0	0	0	0	0	1	9320	991	35	4		4	MAP7D1	1	36644168	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08	24760345	36644168	212606453	2	5979											
SH3GLB1	51100	broad.mit.edu	37	chr1	87170606	87170606	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatcatggacttcaacgtGaagaagctggcggccgacgc	12	7	12	10	4	2	2	2	1	0	1	2	4	2	3	1	3	2	1	1	3	5	2	rs150324653	byFrequency	TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr1:87170606G>T	uc001dlw.2	+	1	350	c.24G>T	c.(22-24)GTG>GTT	p.V8V	SH3GLB1_uc001dlx.2_Silent_p.V8V|SH3GLB1_uc001dly.2_Silent_p.V8V|SH3GLB1_uc001dlz.2_5'UTR	NM_016009	NP_057093	Q9Y371	SHLB1_HUMAN	SH3-containing protein SH3GLB1	8	Membrane-binding amphipathic helix.			V->M: Abolishes interaction with BAX.	anti-apoptosis|filopodium assembly|signal transduction	Golgi membrane|mitochondrial outer membrane	cytoskeletal adaptor activity|protein homodimerization activity|SH3 domain binding				0		Lung NSC(277;0.209)		all cancers(265;0.0136)|Epithelial(280;0.0414)		ACTTCAACGTGAAGAAGCTGG	0.716													4	10					2.0095e-06	2.08392e-06	1	0	T	87170606	T	T	87170606	2	4	30	1	0	0	0	0	0	0	0	1	14318	1277	45	2		2	SH3GLB1	1	87170606	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08	50526438	87170606	162080015	3	5980											
TMEM206	55248	broad.mit.edu	37	chr1	212583849	212583849	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagttctcaaccacctggacCaactcctcactcagctaaag	12	8	6	15	0	3	0	3	0	1	0	5	2	4	1	4	1	3	2	4	1	4	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr1:212583849C>T	uc001hjc.3	-	2	219	c.51G>A	c.(49-51)TTG>TTA	p.L17L	TMEM206_uc010pte.1_Silent_p.L78L	NM_018252	NP_060722	Q9H813	TM206_HUMAN	transmembrane protein 206	17	Cytoplasmic (Potential).					integral to membrane				breast(1)	1				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		CCACCTGGACCAACTCCTCAC	0.502													88	274					0	0	0	0	T	212583849	T	T	212583849	2	4	30	1	0	0	0	0	0	0	0	1	16197	593	21	4		4	TMEM206	1	212583849	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	125413243	212583849	36666772	4	5981											
CNTNAP5	129684	broad.mit.edu	37	chr2	125192141	125192141	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgagtactctcaaagatGtgatctccctgaagttcaag	12	12	9	8	0	3	5	2	4	2	1	5	5	3	5	1	0	1	2	1	0	4	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr2:125192141G>A	uc002tno.2	+	5	974	c.610G>A	c.(610-612)GTG>ATG	p.V204M	CNTNAP5_uc010flu.2_Missense_Mutation_p.V204M	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	204	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCTCAAAGATGTGATCTCCCT	0.493													14	44					0	0	0	0	A	125192141	A	A	125192141	3	1	30	1	0	0	0	0	1	0	0	0	3665	1377	48	4	628	4	CNTNAP5	2	125192141	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08		125192141	118007232	5	5982											
DHRS9	10170	broad.mit.edu	37	chr2	169948429	169948429	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagcagctgtctccagacatCaaacaacaatatggagaagg	16	6	10	9	0	2	2	1	0	1	2	3	4	2	2	1	2	4	2	1	2	5	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr2:169948429C>G	uc002uep.2	+	7	2206	c.702C>G	c.(700-702)ATC>ATG	p.I234M	DHRS9_uc002ueq.2_Missense_Mutation_p.I234M|DHRS9_uc010zdc.1_Missense_Mutation_p.I294M|DHRS9_uc010zdd.1_Missense_Mutation_p.I234M|DHRS9_uc010zde.1_Missense_Mutation_p.I234M	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	234					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						CTCCAGACATCAAACAACAAT	0.413													8	31					0	0	0	0	G	169948429	G	G	169948429	3	3	30	1	0	0	0	0	1	0	0	0	4520	816	29	2	712	2	DHRS9	2	169948429	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08	44756288	169948429	73250944	6	5983											
CYP27A1	1593	broad.mit.edu	37	chr2	219679314	219679314	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggtgtcccgggaccccactgCcttctctgagcctgaaagct	6	9	11	15	1	1	2	0	2	1	0	3	3	2	3	5	2	3	1	5	2	1	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr2:219679314C>T	uc002viz.3	+	8	1744	c.1310C>T	c.(1309-1311)GCC>GTC	p.A437V		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	437					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	GACCCCACTGCCTTCTCTGAG	0.582													15	50					0	0	0	0	T	219679314	T	T	219679314	3	4	30	1	0	0	0	0	1	0	0	0	4175	739	26	4	1340	4	CYP27A1	2	219679314	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08	49730885	219679314	23520059	7	5984											
PER2	8864	broad.mit.edu	37	chr2	239186554	239186554	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggggttactggggctgggCggaaattccgcgtatccatt	6	11	16	8	3	0	0	0	0	0	0	2	1	2	1	2	6	1	3	2	6	3	4			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr2:239186554C>A	uc002vyc.2	-	2	261	c.24G>T	c.(22-24)CCG>CCT	p.P8P	PER2_uc010znv.1_Silent_p.P8P|PER2_uc010znw.1_Silent_p.P8P|PER2_uc010fyx.1_Silent_p.P8P	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	8					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TGGGGCTGGGCGGAAATTCCG	0.602													8	28					1.12685e-05	1.15433e-05	1	0	A	239186554	A	A	239186554	2	1	30	1	0	0	0	0	0	0	0	1	11784	755	27	3		3	PER2	2	239186554	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	19507240	239186554	4012819	8	5985											
METTL6	131965	broad.mit.edu	37	chr3	15466554	15466554	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgggaataaacagtttccaaCcccacagccagcttcaagca	14	7	7	13	0	1	0	1	0	0	0	2	1	2	1	4	1	5	3	4	1	5	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr3:15466554C>T	uc003bzs.1	-	3	526	c.268G>A	c.(268-270)GTT>ATT	p.V90I	METTL6_uc011avp.1_Intron|METTL6_uc003bzt.1_Missense_Mutation_p.V90I|EAF1_uc003bzu.2_5'Flank|EAF1_uc011avq.1_5'Flank	NM_152396	NP_689609	Q8TCB7	METL6_HUMAN	methyltransferase like 6	90							methyltransferase activity				0						CAGTTTCCAACCCCACAGCCA	0.373													15	48					0	0	0	0	T	15466554	T	T	15466554	3	4	30	1	0	0	0	0	1	0	0	0	9557	507	18	4	602	4	METTL6	3	15466554	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08		15466554	182555876	9	5986											
GALNTL2	117248	broad.mit.edu	37	chr3	16264172	16264172	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cactttggcagcccacagcaCctgtgctttgctgtcaggca	7	10	10	14	0	1	0	1	0	0	0	1	0	1	0	2	2	4	5	2	2	0	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr3:16264172C>T	uc003car.3	+	9	2155	c.1680C>T	c.(1678-1680)CAC>CAT	p.H560H	GALNTL2_uc003caq.3_Silent_p.H293H|GALNTL2_uc003cas.3_Silent_p.H90H	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	560	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						GCCCACAGCACCTGTGCTTTG	0.542													68	80					0	0	0	0	T	16264172	T	T	16264172	2	4	30	1	0	0	0	0	0	0	0	1	6257	506	18	4		4	GALNTL2	3	16264172	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	797618	16264172	181758258	10	5987											
GOLGB1	2804	broad.mit.edu	37	chr3	121416590	121416590	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taatttcaaccccaagagaaAacttctcttcattaagctga	15	12	4	10	0	3	2	2	1	1	1	4	3	3	2	2	0	3	1	2	0	6	5			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr3:121416590A>G	uc003eei.3	-	13	2891	c.2765T>C	c.(2764-2766)TTT>TCT	p.F922S	GOLGB1_uc010hrc.2_Missense_Mutation_p.F927S|GOLGB1_uc003eej.3_Missense_Mutation_p.F888S|GOLGB1_uc011bjm.1_Missense_Mutation_p.F808S|GOLGB1_uc010hrd.1_Missense_Mutation_p.F886S	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	922	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		CCCAAGAGAAAACTTCTCTTC	0.378													33	64					0	0	0	0	G	121416590	G	G	121416590	3	3	30	1	0	0	0	0	1	0	0	0	6602	14	1	5	7054	5	GOLGB1	3	121416590	Missense_Mutation	SNP	A	TCGA-BB-7863-01A-11D-2229-08	105152418	121416590	76605840	11	5988											
SEMA5B	54437	broad.mit.edu	37	chr3	122634457	122634457	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgaagcccccatcccgtgtCacattccgcacctgaagaca	10	6	7	18	3	1	2	1	1	0	1	3	3	3	2	6	0	1	1	6	0	2	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr3:122634457C>T	uc003efz.1	-	14	2122	c.1818G>A	c.(1816-1818)GTG>GTA	p.V606V	SEMA5B_uc011bju.1_Silent_p.V548V|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.V606V|SEMA5B_uc010hro.1_Silent_p.V548V	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	606	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CATCCCGTGTCACATTCCGCA	0.557													8	20					0	0	0	0	T	122634457	T	T	122634457	2	4	30	1	0	0	0	0	0	0	0	1	14103	813	29	2		2	SEMA5B	3	122634457	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	1217867	122634457	75387973	12	5989											
PIK3CA	5290	broad.mit.edu	37	chr3	178917478	178917478	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tttatgtaattttattaaagGttttgctatcggcatgccag	10	18	8	5	1	0	0	0	0	0	0	1	0	0	0	1	2	2	4	1	2	6	9			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr3:178917478G>A	uc003fjk.2	+	3	510	c.353G>A	c.(352-354)GGT>GAT	p.G118D		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	118					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G118D(6)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTTATTAAAGGTTTTGCTATC	0.338		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			28	26					0	0	0	0	A	178917478	A	A	178917478	3	1	30	1	0	0	0	0	1	0	0	0	11968	1275	44	4	359	4	PIK3CA	3	178917478	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	56283021	178917478	19104952	13	5990											
GAK	2580	broad.mit.edu	37	chr4	884350	884350	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccactgccagcggggcccaCgggagggggtggccctcggg	4	3	20	14	3	0	0	0	0	0	0	1	1	0	1	4	7	2	0	4	7	0	0	rs150270892	byFrequency	TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr4:884350C>T	uc003gbm.3	-	10	1250	c.1051G>A	c.(1051-1053)GTG>ATG	p.V351M	GAK_uc003gbn.3_Missense_Mutation_p.V272M|GAK_uc010ibk.1_Missense_Mutation_p.V245M|GAK_uc003gbl.3_Missense_Mutation_p.V215M	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	351					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		GCGGGGCCCACGGGAGGGGGT	0.642													11	46					0	0	0	0	T	884350	T	T	884350	3	4	30	1	0	0	0	0	1	0	0	0	6230	536	19	1	2960	1	GAK	4	884350	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08		884350	190269926	14	5991											
SH3TC1	54436	broad.mit.edu	37	chr4	8214503	8214503	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctacagcagaccctccgggGccagctccgcctgctggaga	7	5	12	17	2	0	2	0	0	0	2	2	3	2	2	6	3	4	3	6	3	1	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr4:8214503G>A	uc003gkv.3	+	4	424	c.323G>A	c.(322-324)GGC>GAC	p.G108D	SH3TC1_uc003gkw.3_Missense_Mutation_p.G32D|SH3TC1_uc003gkx.3_RNA	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	108							binding			large_intestine(2)|pancreas(1)	3						ACCCTCCGGGGCCAGCTCCGC	0.687													7	19					0	0	0	0	A	8214503	A	A	8214503	3	1	30	1	0	0	0	0	1	0	0	0	14326	1203	42	4	333	4	SH3TC1	4	8214503	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	7330153	8214503	182939773	15	5992											
PCDH7	5099	broad.mit.edu	37	chr4	30725117	30725117	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttctattgaaaatgacacGgggaccatttactccacaat	13	13	6	9	1	1	2	0	2	1	0	2	3	2	3	2	2	1	0	2	2	5	6			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr4:30725117G>A	uc003gsk.1	+	1	3081	c.2073G>A	c.(2071-2073)ACG>ACA	p.T691T	PCDH7_uc011bxw.1_Silent_p.T644T|PCDH7_uc011bxx.1_Silent_p.T691T	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	691	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						AAAATGACACGGGGACCATTT	0.483													28	108					0	0	0	0	A	30725117	A	A	30725117	2	1	30	1	0	0	0	0	0	0	0	1	11570	1103	39	1		1	PCDH7	4	30725117	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08	22510614	30725117	160429159	16	5993											
APBB2	323	broad.mit.edu	37	chr4	41015609	41015609	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccaggggtacctgtttcatCcggggagctgggtgaggcac	6	8	16	11	1	1	1	1	1	0	0	2	2	2	2	3	6	2	4	3	6	1	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr4:41015609C>T	uc003gvl.2	-	6	1456	c.826G>A	c.(826-828)GAT>AAT	p.D276N	APBB2_uc003gvm.2_Missense_Mutation_p.D276N|APBB2_uc003gvn.2_Missense_Mutation_p.D276N|APBB2_uc011byt.1_Missense_Mutation_p.D259N	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	276					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						CCTGTTTCATCCGGGGAGCTG	0.512													35	149					0	0	0	0	T	41015609	T	T	41015609	3	4	30	1	0	0	0	0	1	0	0	0	761	855	30	2	1505	2	APBB2	4	41015609	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08	10290492	41015609	150138667	17	5994											
PSD2	84249	broad.mit.edu	37	chr5	139218317	139218317	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctccatgaagaagttctGtcggcccctgctgccctcct	6	10	9	16	1	1	2	0	1	1	1	4	2	3	2	5	1	3	3	5	1	2	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr5:139218317G>A	uc003leu.1	+	13	2133	c.1928G>A	c.(1927-1929)TGT>TAT	p.C643Y		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	643					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAAGTTCTGTCGGCCCCTG	0.617													17	74					0	0	0	0	A	139218317	A	A	139218317	3	1	30	1	0	0	0	0	1	0	0	0	12709	1377	48	4	1974	4	PSD2	5	139218317	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08		139218317	41696943	18	5995											
PCDHB6	56130	broad.mit.edu	37	chr5	140531568	140531568	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccgagctggtgccccgggCggccgagccgggctacctgg	4	4	17	16	5	0	0	0	0	0	0	0	2	0	0	6	5	4	2	6	5	1	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr5:140531568C>T	uc003lir.2	+	1	1730	c.1730C>T	c.(1729-1731)GCG>GTG	p.A577V	PCDHB6_uc011dah.1_Missense_Mutation_p.A441V	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	577	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGCCCCGGGCGGCCGAGCCG	0.697													17	74					0	0	0	0	T	140531568	T	T	140531568	3	4	30	1	0	0	0	0	1	0	0	0	11600	768	27	1	1732	1	PCDHB6	5	140531568	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08	1313251	140531568	40383692	19	5996											
OR2H1	26716	broad.mit.edu	37	chr6	29430086	29430086	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactttttatgtgaggtcccAtctctgattcgactctcctg	6	16	8	11	1	2	2	0	2	2	0	6	4	3	2	2	1	0	0	2	1	1	4			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr6:29430086A>G	uc003nmi.2	+	3	983	c.540A>G	c.(538-540)CCA>CCG	p.P180P	OR2H1_uc003nmj.1_Silent_p.P180P|OR2H1_uc010jri.1_Silent_p.P102P	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTGAGGTCCCATCTCTGATTC	0.502													44	176					0	0	0	0	G	29430086	G	G	29430086	2	3	30	1	0	0	0	0	0	0	0	1	11055	204	8	5		5	OR2H1	6	29430086	Silent	SNP	A	TCGA-BB-7863-01A-11D-2229-08		29430086	141684981	20	5997											
BAT4	7918	broad.mit.edu	37	chr6	31630061	31630062	+	Frame_Shift_Ins	INS	-	T	T																															gtcagaactcgaggttcatgINStaagtccttagatcccgctc																										TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr6:31630061_31630062insT	uc003nvn.2	-	3	1697_1698	c.1052_1053insA	c.(1051-1053)TACfs	p.Y351fs	C6orf47_uc003nvm.1_5'Flank|BAT4_uc003nvo.3_Frame_Shift_Ins_p.Y351fs|BAT4_uc003nvp.3_Frame_Shift_Ins_p.Y351fs|BAT4_uc003nvq.2_Frame_Shift_Ins_p.Y351fs	NM_033177	NP_149417	O95872	GPAN1_HUMAN	HLA-B associated transcript 4	351						intracellular	nucleic acid binding				0						CGAGGTTCATGTAAGTCCTTAG	0.579													---	---	---								T	31630062	T	T	31630061	7	5	30	1	0	1	1	0	0	0	0	0	1325	1372	48	0	21	0	BAT4	6	31630061	Frame_Shift_Ins	INS	-	TCGA-BB-7863-01A-11D-2229-08	2199975	31630061	139485006	21	5998											
SPDEF	25803	broad.mit.edu	37	chr6	34506204	34506204	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccccacagccgggccacctgGgctgagtcctcaattttgaa	8	8	10	15	1	1	2	1	2	0	0	2	2	2	2	6	2	1	1	6	2	2	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr6:34506204G>A	uc003ojq.1	-	6	1270	c.855C>T	c.(853-855)GCC>GCT	p.A285A	SPDEF_uc011dsq.1_Silent_p.A269A	NM_012391	NP_036523	O95238	SPDEF_HUMAN	SAM pointed domain containing ets transcription	285	ETS.				negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(3)|ovary(1)|central_nervous_system(1)	5						GGGCCACCTGGGCTGAGTCCT	0.587													23	96					0	0	0	0	A	34506204	A	A	34506204	2	1	30	1	0	0	0	0	0	0	0	1	15092	1219	43	4		4	SPDEF	6	34506204	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08	2876143	34506204	136608863	22	5999											
SYNE1	23345	broad.mit.edu	37	chr6	152451909	152451909	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgagagactacacttgcctCgtggctgtttgcaatgaaca	10	11	11	9	1	0	3	0	2	0	1	1	4	0	3	1	1	4	3	1	1	3	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr6:152451909C>T	uc010kiw.2	-	145	26701	c.26099G>A	c.(26098-26100)CGA>CAA	p.R8700Q	SYNE1_uc010kiv.2_Missense_Mutation_p.R3224Q|SYNE1_uc003qos.3_Missense_Mutation_p.R3224Q|SYNE1_uc003qot.3_Missense_Mutation_p.R8652Q|SYNE1_uc003qou.3_Missense_Mutation_p.R8700Q|SYNE1_uc003qop.3_Missense_Mutation_p.R885Q|SYNE1_uc011eez.1_Intron|SYNE1_uc003qoq.3_Intron|SYNE1_uc003qor.3_Intron	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8700	Ser-rich.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACACTTGCCTCGTGGCTGTTT	0.458										HNSCC(10;0.0054)			8	33					0	0	0	0	T	152451909	T	T	152451909	3	4	30	1	0	0	0	0	1	0	0	0	15511	884	31	1	302	1	SYNE1	6	152451909	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08	117945705	152451909	18663158	23	6000											
C7orf27	221927	broad.mit.edu	37	chr7	2578389	2578389	+	Frame_Shift_Del	DEL	G	-	-																															gaggatgtgcaggagctccaGgaacaggctctgggggacag																										TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr7:2578389delG	uc003smi.2	-	14	1822	c.1780delC	c.(1780-1782)CTGfs	p.L594fs	C7orf27_uc003smh.3_Frame_Shift_Del_p.L26fs	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	594					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		AGGAGCTCCAGGAACAGGCTC	0.647													---	---	---								-	2578389	-	-	2578389	7	5	30	1	0	1	0	1	0	0	0	0	2393	991	35	0	689	0	C7orf27	7	2578389	Frame_Shift_Del	DEL	G	TCGA-BB-7863-01A-11D-2229-08		2578389	156560274	24	6001											
COBL	23242	broad.mit.edu	37	chr7	51203860	51203860	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcccactgccctaccttttCcgatgccttgtcttgcacag	6	12	7	16	1	1	0	0	0	1	0	2	1	2	0	5	0	5	1	5	0	1	5			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr7:51203860C>A	uc003tpr.3	-	6	1137	c.952G>T	c.(952-954)GAA>TAA	p.E318*	COBL_uc003tps.2_Nonsense_Mutation_p.E318*|COBL_uc011kcl.1_Nonsense_Mutation_p.E318*|COBL_uc010kzc.2_Nonsense_Mutation_p.E318*|COBL_uc003tpt.2_Nonsense_Mutation_p.E318*|COBL_uc003tpp.3_Nonsense_Mutation_p.E47*|COBL_uc003tpq.3_Nonsense_Mutation_p.E259*	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	318	Pro-rich.									skin(3)|ovary(2)	5	Glioma(55;0.08)					CCTACCTTTTCCGATGCCTTG	0.542													22	41					1.64293e-13	1.74692e-13	1	0	A	51203860	A	A	51203860	4	1	30	1	0	0	0	0	0	1	0	0	3668	864	30	2	2865	2	COBL	7	51203860	Nonsense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08	48625471	51203860	107934803	25	6002											
COL1A2	1278	broad.mit.edu	37	chr7	94038721	94038721	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccaggcctctccggccccGttggacctcctgtaagtagc	5	10	10	16	2	1	0	0	0	1	0	4	1	3	1	7	3	1	3	7	3	2	4	rs145693444	byFrequency	TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr7:94038721G>A	uc003ung.1	+	17	1351	c.880G>A	c.(880-882)GTT>ATT	p.V294I	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	294					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CTCCGGCCCCGTTGGACCTCC	0.502										HNSCC(75;0.22)			35	45					0	0	0	0	A	94038721	A	A	94038721	3	1	30	1	0	0	0	0	1	0	0	0	3693	1145	40	1	946	1	COL1A2	7	94038721	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	42834861	94038721	65099942	26	6003											
C7orf58	79974	broad.mit.edu	37	chr7	120906436	120906436	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atcagttattcctactatccCcagttctggataagcccttc	9	14	5	13	0	2	0	1	0	1	0	5	1	4	1	4	1	2	2	4	1	4	7	rs145128194		TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr7:120906436C>T	uc003vjq.3	+	19	2913	c.2466C>T	c.(2464-2466)CCC>CCT	p.P822P		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	822						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CCTACTATCCCCAGTTCTGGA	0.403													30	103					0	0	0	0	T	120906436	T	T	120906436	2	4	30	1	0	0	0	0	0	0	0	1	2416	610	22	4		4	C7orf58	7	120906436	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	26867715	120906436	38232227	27	6004											
SGK223	157285	broad.mit.edu	37	chr8	8235417	8235417	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcctctcgccgcggggctCaaggttgtgcaggccgacca	5	8	14	14	4	2	0	1	0	1	0	4	1	3	0	4	4	1	4	4	4	1	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr8:8235417C>T	uc003wsh.3	-	2	502	c.502G>A	c.(502-504)GAG>AAG	p.E168K		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	168							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CCGCGGGGCTCAAGGTTGTGC	0.592													23	50					0	0	0	0	T	8235417	T	T	8235417	3	4	30	1	0	0	0	0	1	0	0	0	14275	835	29	2	3722	2	SGK223	8	8235417	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08		8235417	138128605	28	6005											
SCARA3	51435	broad.mit.edu	37	chr8	27509034	27509034	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtcccccacaggccggccagGgccccgctgcagccgctgcc	4	3	13	21	3	0	0	0	0	0	0	1	0	1	0	8	3	3	3	8	3	0	0			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr8:27509034G>A	uc003xga.1	+	3	257	c.116G>A	c.(115-117)GGG>GAG	p.G39E	SCARA3_uc003xgb.1_Missense_Mutation_p.G39E	NM_016240	NP_057324	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3 isoform 1	39	Cytoplasmic (Potential).				response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			skin(2)|ovary(1)|breast(1)	4		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		GGCCGGCCAGGGCCCCGCTGC	0.617													12	38					0	0	0	0	A	27509034	A	A	27509034	3	1	30	1	0	0	0	0	1	0	0	0	13944	1232	43	4	126	4	SCARA3	8	27509034	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	19273617	27509034	118854988	29	6006											
IKBKB	3551	broad.mit.edu	37	chr8	42177162	42177162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctgtggagctctgtgggCgggtaggagactcattttgg	6	11	18	6	1	2	1	1	0	1	1	2	3	2	2	0	6	1	3	0	6	1	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr8:42177162C>T	uc003xow.1	+	15	1753	c.1576C>T	c.(1576-1578)CGG>TGG	p.R526W	IKBKB_uc010lxh.1_3'UTR|IKBKB_uc011lco.1_Intron|IKBKB_uc010lxj.1_Missense_Mutation_p.R303W|IKBKB_uc003xox.1_Missense_Mutation_p.R247W|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.R524W|IKBKB_uc010lxi.1_Intron|IKBKB_uc011lcr.1_Missense_Mutation_p.R467W	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	526					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GCTCTGTGGGCGGGTAGGAGA	0.438											OREG0018747	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	22					0	0	0	0	T	42177162	T	T	42177162	3	4	30	1	0	0	0	0	1	0	0	0	7650	759	27	1	1630	1	IKBKB	8	42177162	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08	14668128	42177162	104186860	30	6007											
SOX17	64321	broad.mit.edu	37	chr8	55372477	55372477	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gactccggtgtgaatctcccCgacagccacggggccatttc	7	8	11	15	3	1	1	0	1	1	0	4	3	2	1	5	3	1	0	5	3	1	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr8:55372477C>T	uc003xsb.3	+	2	1371	c.1167C>T	c.(1165-1167)CCC>CCT	p.P389P		NM_022454	NP_071899	Q9H6I2	SOX17_HUMAN	SRY-box 17	389	Sox C-terminal.				angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			lung(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			TGAATCTCCCCGACAGCCACG	0.607													23	66					0	0	0	0	T	55372477	T	T	55372477	2	4	30	1	0	0	0	0	0	0	0	1	15011	639	23	1		1	SOX17	8	55372477	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	13195315	55372477	90991545	31	6008											
SNX31	169166	broad.mit.edu	37	chr8	101589289	101589289	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttacttttgctttgttcCggaacttcaatctgctagat	7	20	6	8	1	2	1	1	0	1	1	3	2	3	2	1	1	4	3	1	1	4	9	rs149337394	byFrequency	TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr8:101589289C>G	uc003yjr.2	-	13	1336	c.1185G>C	c.(1183-1185)CCG>CCC	p.P395P	SNX31_uc011lha.1_Silent_p.P190P|SNX31_uc011lhb.1_Silent_p.P296P	NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	sorting nexin 31	395					cell communication|protein transport		phosphatidylinositol binding				0	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TGCTTTGTTCCGGAACTTCAA	0.348													43	101					0	0	0	0	G	101589289	G	G	101589289	2	3	30	1	0	0	0	0	0	0	0	1	14965	639	23	3		3	SNX31	8	101589289	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	46216812	101589289	44774733	32	6009											
OR13F1	138805	broad.mit.edu	37	chr9	107267480	107267480	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagaaatcattttaatactGccttcatttccatcctcaaa	13	16	2	10	0	3	1	3	0	0	1	5	1	5	1	3	0	2	0	3	0	5	6			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr9:107267480G>A	uc011lvm.1	+	1	937	c.937G>A	c.(937-939)GCC>ACC	p.A313T		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						TTTTAATACTGCCTTCATTTC	0.358													12	40					0	0	0	0	A	107267480	A	A	107267480	3	1	30	1	0	0	0	0	1	0	0	0	10995	1319	46	4	939	4	OR13F1	9	107267480	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08		107267480	33945951	33	6010											
NOTCH1	4851	broad.mit.edu	37	chr9	139400209	139400209	+	Frame_Shift_Del	DEL	C	-	-																															ccgggaactggcattcggggCccgtgaaggggcccaggcac																										TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr9:139400209delC	uc004chz.2	-	25	4139	c.4139delG	c.(4138-4140)GGCfs	p.G1380fs	NOTCH1_uc004cia.1_Frame_Shift_Del_p.G610fs	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1380	Extracellular (Potential).|EGF-like 35.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCATTCGGGGCCCGTGAAGGG	0.697			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								-	139400209	-	-	139400209	7	5	30	1	0	1	0	1	0	0	0	0	10601	739	26	0	3568	0	NOTCH1	9	139400209	Frame_Shift_Del	DEL	C	TCGA-BB-7863-01A-11D-2229-08	32132729	139400209	1813222	34	6011											
ITGA8	8516	broad.mit.edu	37	chr10	15590480	15590480	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggtgtgggcccataatcGtgacctgactttcaggactg	9	10	13	9	1	1	2	1	2	0	0	2	4	1	3	2	3	0	0	2	3	2	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr10:15590480G>A	uc001ioc.1	-	27	2854	c.2854C>T	c.(2854-2856)CGA>TGA	p.R952*	ITGA8_uc010qcb.1_Nonsense_Mutation_p.R937*	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	952	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GCCCATAATCGTGACCTGACT	0.483													9	36					0	0	0	0	A	15590480	A	A	15590480	4	1	30	1	0	0	0	0	0	1	0	0	7921	1153	40	1	353	1	ITGA8	10	15590480	Nonsense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08		15590480	119944267	35	6012											
EIF3A	8661	broad.mit.edu	37	chr10	120795718	120795718	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctgggggaggaactcgacGaggagggtcccgctcttcca	8	6	16	11	3	1	0	0	0	1	0	4	5	3	3	2	5	2	2	2	5	1	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr10:120795718G>A	uc001ldu.2	-	22	4128	c.3982C>T	c.(3982-3984)CGT>TGT	p.R1328C	EIF3A_uc010qsu.1_Missense_Mutation_p.R1294C	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	1328					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		GGAACTCGACGAGGAGGGTCC	0.448													12	45					0	0	0	0	A	120795718	A	A	120795718	3	1	30	1	0	0	0	0	1	0	0	0	5034	1058	37	1	170	1	EIF3A	10	120795718	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	105205238	120795718	14739029	36	6013											
OR10A2	341276	broad.mit.edu	37	chr11	6891253	6891255	+	In_Frame_Del	DEL	TTC	-	-																															gctgtgccactcagatgtatTtcttcttcttctttggagtg																										TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr11:6891253_6891255delTTC	uc001meu.1	+	1	268_270	c.268_270delTTC	c.(268-270)TTCdel	p.F94del		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	94	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TCAGATGTATTTCTTCTTCTTCT	0.517													---	---	---								-	6891255	-	-	6891253	7	5	30	1	0	1	0	1	0	0	0	0	10944	1841	64	0	270	0	OR10A2	11	6891253	In_Frame_Del	DEL	TTC	TCGA-BB-7863-01A-11D-2229-08		6891253	128115263	37	6014											
FAT3	120114	broad.mit.edu	37	chr11	92532047	92532047	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactacatgctgatagttaaGgtgtctgatggaaagttcta	12	13	10	6	0	2	2	0	2	2	0	2	3	2	3	0	2	2	3	0	2	5	5			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr11:92532047G>A	uc001pdj.3	+	9	5885	c.5868G>A	c.(5866-5868)AAG>AAA	p.K1956K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1956	Cadherin 17.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGATAGTTAAGGTGTCTGATG	0.418										TCGA Ovarian(4;0.039)			11	28					0	0	0	0	A	92532047	A	A	92532047	2	1	30	1	0	0	0	0	0	0	0	1	5723	991	35	4		4	FAT3	11	92532047	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08	85640794	92532047	42474469	38	6015											
CD163L1	283316	broad.mit.edu	37	chr12	7548909	7548909	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgcagctttactgttccagCcgtcatcacacactgtgccc	7	11	7	16	1	2	0	2	0	0	0	3	0	3	0	3	0	5	3	3	0	1	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr12:7548909C>T	uc001qsy.2	-	8	1858	c.1832G>A	c.(1831-1833)GGC>GAC	p.G611D	CD163L1_uc010sge.1_Missense_Mutation_p.G621D	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	611	SRCR 6.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ACTGTTCCAGCCGTCATCACA	0.562													12	45					0	0	0	0	T	7548909	T	T	7548909	3	4	30	1	0	0	0	0	1	0	0	0	2983	739	26	4	2577	4	CD163L1	12	7548909	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08		7548909	126302986	39	6016											
TAS2R19	259294	broad.mit.edu	37	chr12	11174603	11174603	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaaaacatattaggctcaGagtaaagggtatgaggtttg	15	10	12	4	0	1	3	1	1	0	2	1	3	1	3	0	3	1	4	0	3	7	5			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr12:11174603G>C	uc010shj.1	-	1	568	c.568C>G	c.(568-570)CTG>GTG	p.L190V	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176888	NP_795369	P59542	T2R19_HUMAN	taste receptor, type 2, member 19	190	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1						ATTAGGCTCAGAGTAAAGGGT	0.398													23	112					0	0	0	0	C	11174603	C	C	11174603	3	2	30	1	0	0	0	0	1	0	0	0	15636	933	33	2	334	2	TAS2R19	12	11174603	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	3625694	11174603	122677292	40	6017											
ARID2	196528	broad.mit.edu	37	chr12	46233255	46233255	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatagagcaagtccaaaccCagactcatgtagcatctgcc	13	8	7	13	0	2	2	1	0	1	2	3	2	3	2	3	0	4	3	3	0	5	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr12:46233255C>T	uc001ros.1	+	11	1474	c.1474C>T	c.(1474-1476)CAG>TAG	p.Q492*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q492*|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q119*|ARID2_uc001rot.1_Nonsense_Mutation_p.Q138*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	492					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AGTCCAAACCCAGACTCATGT	0.398													29	124					0	0	0	0	T	46233255	T	T	46233255	4	4	30	1	0	0	0	0	0	1	0	0	915	595	21	4	1516	4	ARID2	12	46233255	Nonsense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08	35058652	46233255	87618640	41	6018											
FRY	10129	broad.mit.edu	37	chr13	32783029	32783029	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaacacaccccaacgggcGccagatcatgcttacctacc	12	5	6	18	2	1	1	1	0	0	1	1	1	1	1	5	1	5	1	5	1	4	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr13:32783029G>A	uc001utx.2	+	32	4554	c.4058G>A	c.(4057-4059)CGC>CAC	p.R1353H	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCCAACGGGCGCCAGATCATG	0.557													14	46					0	0	0	0	A	32783029	A	A	32783029	3	1	30	1	0	0	0	0	1	0	0	0	6097	1087	38	1	4184	1	FRY	13	32783029	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08		32783029	82386849	42	6019											
CMA1	1215	broad.mit.edu	37	chr14	24976687	24976687	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taggggcgggaatgtggcttGcattctgtgcccccgatgat	6	11	15	9	2	1	1	0	1	1	0	1	3	1	2	2	4	2	2	2	4	2	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr14:24976687G>A	uc001wpp.1	-	2	114	c.84C>T	c.(82-84)TGC>TGT	p.C28C	CMA1_uc010alx.1_Intron	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	28	Peptidase S1.			C -> S (in Ref. 7; AAB26828).	interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		AATGTGGCTTGCATTCTGTGC	0.493													38	154					0	0	0	0	A	24976687	A	A	24976687	2	1	30	1	0	0	0	0	0	0	0	1	3589	1311	46	4		4	CMA1	14	24976687	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08		24976687	82372853	43	6020											
LOXL1	4016	broad.mit.edu	37	chr15	74241808	74241808	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcttcctcaggtgcacgtGaacccaaagtatattgtttt	9	15	7	10	1	2	1	1	1	1	0	3	1	3	1	2	1	2	3	2	1	4	7			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr15:74241808G>A	uc002awc.1	+	6	1947	c.1611G>A	c.(1609-1611)GTG>GTA	p.V537V	LOXL1_uc002awd.1_RNA	NM_005576	NP_005567	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1 preproprotein	537	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding				0						AGGTGCACGTGAACCCAAAGT	0.423													33	144					0	0	0	0	A	74241808	A	A	74241808	2	1	30	1	0	0	0	0	0	0	0	1	8949	1277	45	2		2	LOXL1	15	74241808	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08		74241808	28289584	44	6021											
MRPL28	10573	broad.mit.edu	37	chr16	420374	420374	+	5'Flank	DEL	C	-	-																															gctctcacccgctaccccggCccccggctctcacccgctac																										TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr16:420374delC	uc002cgr.1	-						MRPL28_uc010bqu.1_5'Flank|MRPL28_uc002cgs.1_Intron|MRPL28_uc002cgt.1_Intron	NM_006428	NP_006419	Q13084	RM28_HUMAN	mitochondrial ribosomal protein L28 precursor						translation	mitochondrial ribosome	protein binding|structural constituent of ribosome				0		Hepatocellular(16;0.000105)|Lung NSC(18;0.0324)|all_lung(18;0.064)				gctaccccggcccccggctct	0.04													---	---	---								-	420374	-	-	420374	6	5	30	0	1	1	0	1	0	0	0	0	9845	754	26	0		0	MRPL28	16	420374	5'Flank	DEL	C	TCGA-BB-7863-01A-11D-2229-08		420374	89934379	45	6022											
ABAT	18	broad.mit.edu	37	chr16	8862755	8862755	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttgactggcccatcgcaccGttcccacggctgaaataccc	8	9	8	16	3	0	2	0	2	0	0	2	2	1	2	4	2	1	3	4	2	2	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr16:8862755G>A	uc002czc.3	+	11	907	c.741G>A	c.(739-741)CCG>CCA	p.P247P	ABAT_uc002czd.3_Silent_p.P247P|ABAT_uc010buh.2_Silent_p.P189P|ABAT_uc010bui.2_Silent_p.P247P	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	247				P -> T (in Ref. 2; AAB38510).	behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	CCATCGCACCGTTCCCACGGC	0.517													57	177					0	0	0	0	A	8862755	A	A	8862755	2	1	30	1	0	0	0	0	0	0	0	1	27	1132	40	1		1	ABAT	16	8862755	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08	8442381	8862755	81491998	46	6023											
FAM65A	79567	broad.mit.edu	37	chr16	67572623	67572623	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccccacggaagccccccgcGctctcccgagtgtccaggat	6	5	10	20	4	1	0	0	0	1	0	3	3	2	2	7	2	1	1	7	2	1	0			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr16:67572623G>A	uc010vjp.1	+	3	309	c.213G>A	c.(211-213)GCG>GCA	p.A71A	FAM65A_uc010cei.1_5'UTR|FAM65A_uc002eth.2_Silent_p.A51A|FAM65A_uc010cej.2_Silent_p.A54A|FAM65A_uc002eti.1_Intron|FAM65A_uc010vjq.1_Silent_p.A65A|FAM65A_uc002etj.1_Silent_p.A50A|FAM65A_uc002etk.2_Silent_p.A50A	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	55						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		AGCCCCCCGCGCTCTCCCGAG	0.682													21	98					0	0	0	0	A	67572623	A	A	67572623	2	1	30	1	0	0	0	0	0	0	0	1	5631	1074	38	1		1	FAM65A	16	67572623	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08	58709868	67572623	22782130	47	6024											
ACSF3	197322	broad.mit.edu	37	chr16	89169065	89169065	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagacgacgtgatcctccaCgtgctcccgctgcaccacgt	9	7	9	16	5	0	2	0	1	0	1	3	3	3	2	4	0	2	3	4	0	1	0			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr16:89169065C>T	uc002fmp.2	+	4	1060	c.720C>T	c.(718-720)CAC>CAT	p.H240H	ACSF3_uc010cig.1_Silent_p.H240H|ACSF3_uc010cih.1_Translation_Start_Site|ACSF3_uc002fmq.1_RNA|ACSF3_uc010cii.1_RNA|ACSF3_uc002fmr.1_Translation_Start_Site	NM_174917	NP_777577	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3 precursor	240					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0281)		TGATCCTCCACGTGCTCCCGC	0.622													18	58					0	0	0	0	T	89169065	T	T	89169065	2	4	30	1	0	0	0	0	0	0	0	1	176	535	19	1		1	ACSF3	16	89169065	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	21596442	89169065	1185688	48	6025											
KDSR	2531	broad.mit.edu	37	chr18	61027014	61027014	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaatttctttctttgcctgCagcagcttatcctgaaagca	9	15	6	11	0	3	1	1	1	2	0	4	1	4	1	2	0	5	4	2	0	3	4			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr18:61027014C>A	uc010dpw.2	-	3	365	c.210G>T	c.(208-210)CTG>CTT	p.L70L	KDSR_uc010xem.1_Silent_p.L70L	NM_002035	NP_002026	Q06136	KDSR_HUMAN	3-ketodihydrosphingosine reductase precursor	70	Cytoplasmic (Potential).				3-keto-sphinganine metabolic process	endoplasmic reticulum membrane|extracellular space|integral to membrane	3-dehydrosphinganine reductase activity|binding			skin(1)	1						TCTTTGCCTGCAGCAGCTTAT	0.348													17	41					0.00887093	0.00887093	1	0	A	61027014	A	A	61027014	2	1	30	1	0	0	0	0	0	0	0	1	8179	697	25	4		4	KDSR	18	61027014	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08		61027014	17050234	49	6026											
C3	718	broad.mit.edu	37	chr19	6696608	6696608	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctgcagccgactcaccacgGcccaggcgttctggatccag	7	6	11	17	3	2	0	1	0	1	0	3	2	3	1	5	3	2	2	5	3	0	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr19:6696608G>A	uc002mfm.2	-	22	2921	c.2859C>T	c.(2857-2859)GGC>GGT	p.G953G		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	953					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACTCACCACGGCCCAGGCGTT	0.597													86	307					0	0	0	0	A	6696608	A	A	6696608	2	1	30	1	0	0	0	0	0	0	0	1	2214	1190	42	4		4	C3	19	6696608	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08		6696608	52432375	50	6027											
INSR	3643	broad.mit.edu	37	chr19	7184413	7184413	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtggcagccctgcctccgCgagttcttgcatttgtggtg	3	13	14	11	2	1	0	0	0	1	0	2	1	2	0	3	3	3	3	3	3	0	3	rs2229428	byFrequency	TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr19:7184413C>T	uc002mgd.1	-	3	997	c.888G>A	c.(886-888)TCG>TCA	p.S296S	INSR_uc002mge.1_Silent_p.S296S|INSR_uc002mgf.2_Silent_p.S296S	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	296	Cys-rich.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTGCCTCCGCGAGTTCTTGC	0.572													13	56					0	0	0	0	T	7184413	T	T	7184413	2	4	30	1	0	0	0	0	0	0	0	1	7812	755	27	1		1	INSR	19	7184413	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	487805	7184413	51944570	51	6028											
DOCK6	57572	broad.mit.edu	37	chr19	11319683	11319683	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgcaccatgcactgggcGgcctcggcgtggttgcccag	4	7	16	14	4	0	0	0	0	0	0	1	0	0	0	3	4	3	3	3	4	0	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr19:11319683G>A	uc002mqs.3	-	38	4889	c.4848C>T	c.(4846-4848)GCC>GCT	p.A1616A	DOCK6_uc002mqr.3_Silent_p.A14A|DOCK6_uc010xlq.1_Silent_p.A955A	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1616	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TGCACTGGGCGGCCTCGGCGT	0.692													5	19					0	0	0	0	A	11319683	A	A	11319683	2	1	30	1	0	0	0	0	0	0	0	1	4713	1103	39	1		1	DOCK6	19	11319683	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08	4135270	11319683	47809300	52	6029											
CYP4F11	57834	broad.mit.edu	37	chr19	16025591	16025591	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttggggatgacgcggccGtctgggagcacaaagtcctg	7	8	15	11	3	1	1	0	1	1	0	2	3	2	3	3	4	1	1	3	4	1	1	rs150098509	byFrequency	TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr19:16025591G>A	uc002nbu.2	-	10	1266	c.1230C>T	c.(1228-1230)GAC>GAT	p.D410D	CYP4F11_uc010eab.1_Silent_p.D410D|CYP4F11_uc002nbt.2_Silent_p.D410D	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	410					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						TGACGCGGCCGTCTGGGAGCA	0.637													30	92					0	0	0	0	A	16025591	A	A	16025591	2	1	30	1	0	0	0	0	0	0	0	1	4203	1136	40	1		1	CYP4F11	19	16025591	Silent	SNP	G	TCGA-BB-7863-01A-11D-2229-08	4705908	16025591	43103392	53	6030											
MLL4	9757	broad.mit.edu	37	chr19	36215897	36215903	+	Frame_Shift_Del	DEL	TGGCCCC	-	-																															ctttcctccccaggatgcttTggcccctggcccctttgctt																										TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr19:36215897_36215903delTGGCCCC	uc010eei.2	+	11	3437_3443	c.3437_3443delTGGCCCC	c.(3436-3444)TTGGCCCCTfs	p.L1146fs		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1146_1148					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAGGATGCTTTGGCCCCTGGCCCCTTT	0.585													---	---	---								-	36215903	-	-	36215897	7	5	30	1	0	1	0	1	0	0	0	0	9676	1821	63	0	3475	0	MLL4	19	36215897	Frame_Shift_Del	DEL	TGGCCCC	TCGA-BB-7863-01A-11D-2229-08	20190306	36215897	22913086	54	6031											
SIGLEC9	27180	broad.mit.edu	37	chr19	51633177	51633177	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaaccttgggcagaagaCagtcccccagaccagcctcc	11	5	9	16	0	0	4	0	1	0	3	2	4	2	4	6	1	2	1	6	1	2	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr19:51633177C>T	uc002pvu.2	+	7	1300	c.1233C>T	c.(1231-1233)GAC>GAT	p.D411D	SIGLEC9_uc010yct.1_Intron	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	411	Cytoplasmic (Potential).				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		GGGCAGAAGACAGTCCCCCAG	0.527													48	92					0	0	0	0	T	51633177	T	T	51633177	2	4	30	1	0	0	0	0	0	0	0	1	14380	477	17	4		4	SIGLEC9	19	51633177	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	15417280	51633177	7495806	55	6032											
ZNF765	91661	broad.mit.edu	37	chr19	53911920	53911920	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagtcggaagtcacattttaCatgccatcatagagttcata	13	13	7	8	1	3	1	3	0	0	1	4	2	3	2	1	1	2	1	1	1	5	6			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr19:53911920C>A	uc010ydx.1	+	6	1439	c.1112C>A	c.(1111-1113)ACA>AAA	p.T371K	ZNF765_uc002qbm.2_Missense_Mutation_p.T371K|ZNF765_uc002qbn.2_Intron	NM_001040185	NP_001035275	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	371	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00379)		TCACATTTTACATGCCATCAT	0.413													20	74					7.45023e-12	7.82274e-12	1	0	A	53911920	A	A	53911920	3	1	30	1	0	0	0	0	1	0	0	0	18206	478	17	4	1122	4	ZNF765	19	53911920	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08	2278743	53911920	5217063	56	6033											
ZNF341	84905	broad.mit.edu	37	chr20	32378906	32378906	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagttccgctgtgctggctgCgccaagggcttttcccgcca	5	10	12	14	3	0	0	0	0	0	0	2	0	2	0	4	2	2	5	4	2	2	3	rs61734271	byFrequency	TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr20:32378906C>T	uc002wzy.2	+	15	2168	c.2148C>T	c.(2146-2148)TGC>TGT	p.C716C	ZNF341_uc002wzx.2_Silent_p.C709C|ZNF341_uc010geq.2_Silent_p.C626C|ZNF341_uc010ger.2_RNA|ZNF341_uc002wzz.2_Silent_p.C143C	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	716					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GTGCTGGCTGCGCCAAGGGCT	0.637													13	44					0	0	0	0	T	32378906	T	T	32378906	2	4	30	1	0	0	0	0	0	0	0	1	17924	776	27	1		1	ZNF341	20	32378906	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08		32378906	30646614	57	6034											
EIF2S2	8894	broad.mit.edu	37	chr20	32677659	32677661	+	In_Frame_Del	DEL	CTT	-	-																															aggaaatagagtcgtgtgtcCttctgcaggattgtgtccgg																										TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr20:32677659_32677661delCTT	uc002xaf.2	-	9	1046_1048	c.877_879delAAG	c.(877-879)AAGdel	p.K293del	EIF2S2_uc002xag.2_In_Frame_Del_p.K290del|EIF2S2_uc010ges.2_In_Frame_Del_p.K233del	NM_003908	NP_003899	P20042	IF2B_HUMAN	eukaryotic translation initiation factor 2 beta	293	C4-type (Potential).					cytosol|eukaryotic translation initiation factor 2 complex	metal ion binding|protein binding|translation initiation factor activity			large_intestine(1)	1						GTCGTGTGTCCTTCTGCAGGATT	0.488													---	---	---								-	32677661	-	-	32677659	7	5	30	1	0	1	0	1	0	0	0	0	5032	680	24	0	126	0	EIF2S2	20	32677659	In_Frame_Del	DEL	CTT	TCGA-BB-7863-01A-11D-2229-08	298753	32677659	30347861	58	6035											
MC3R	4159	broad.mit.edu	37	chr20	54824200	54824200	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaccatcatgatcgccatcGtccacagcgactacctgacc	11	7	7	16	3	1	3	1	2	0	1	4	4	2	3	5	0	2	0	5	0	1	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr20:54824200G>A	uc002xxb.2	+	1	413	c.301G>A	c.(301-303)GTC>ATC	p.V101I		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	138	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			GATCGCCATCGTCCACAGCGA	0.552													13	56					0	0	0	0	A	54824200	A	A	54824200	3	1	30	1	0	0	0	0	1	0	0	0	9418	1145	40	1	303	1	MC3R	20	54824200	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	22146541	54824200	8201320	59	6036											
STMN3	50861	broad.mit.edu	37	chr20	62273563	62273565	+	In_Frame_Del	DEL	GTT	-	-																															tcctccgcctggcggctgaaGttgttattctcctccagcgc																										TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr20:62273563_62273565delGTT	uc002yfr.1	-	4	461_463	c.379_381delAAC	c.(379-381)AACdel	p.N127del	STMN3_uc011abb.1_In_Frame_Del_p.N127del	NM_015894	NP_056978	Q9NZ72	STMN3_HUMAN	SCG10-like-protein	127	Potential.				cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding				0	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			GGCGGCTGAAGTTGTTATTCTCC	0.67													---	---	---								-	62273565	-	-	62273563	7	5	30	1	0	1	0	1	0	0	0	0	15376	1020	36	0	169	0	STMN3	20	62273563	In_Frame_Del	DEL	GTT	TCGA-BB-7863-01A-11D-2229-08	7449363	62273563	751957	60	6037											
UMODL1	89766	broad.mit.edu	37	chr21	43524101	43524101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctcaccgtgcaggaccccGggtttcccatgggcatctcc	6	8	11	16	2	2	0	1	0	1	0	4	1	3	1	5	3	2	4	5	3	0	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr21:43524101G>A	uc002zaf.1	+	9	1423	c.1423G>A	c.(1423-1425)GGG>AGG	p.G475R	UMODL1_uc002zad.1_Missense_Mutation_p.G403R|UMODL1_uc002zae.1_Missense_Mutation_p.G403R|UMODL1_uc002zag.1_Missense_Mutation_p.G475R|UMODL1_uc010gow.1_Missense_Mutation_p.G267R|UMODL1_uc002zai.1_Missense_Mutation_p.G126R|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Missense_Mutation_p.G126R|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.G220R|C21orf128_uc002zak.2_Silent_p.P44P	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	475	Extracellular (Potential).|SEA 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						GCAGGACCCCGGGTTTCCCAT	0.602													30	149					0	0	0	0	A	43524101	A	A	43524101	3	1	30	1	0	0	0	0	1	0	0	0	17048	1116	39	1	1457	1	UMODL1	21	43524101	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08		43524101	4605794	61	6038											
TRMT2A	27037	broad.mit.edu	37	chr22	20101289	20101289	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgcatccaattgggcccagtCctggatgactgtgtagagca	9	9	12	11	1	0	2	0	1	0	1	2	3	2	3	3	2	1	3	3	2	2	2	rs146579566	byFrequency	TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr22:20101289C>T	uc002zrk.1	-	9	1491	c.1276G>A	c.(1276-1278)GAC>AAC	p.D426N	TRMT2A_uc002zrl.1_Missense_Mutation_p.D426N|TRMT2A_uc002zrm.1_Missense_Mutation_p.D248N|TRMT2A_uc002zrn.1_Missense_Mutation_p.D426N	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	426					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						TGGGCCCAGTCCTGGATGACT	0.672													11	35					0	0	0	0	T	20101289	T	T	20101289	3	4	30	1	0	0	0	0	1	0	0	0	16632	855	30	2	621	2	TRMT2A	22	20101289	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08		20101289	31203277	62	6039											
CABIN1	23523	broad.mit.edu	37	chr22	24463009	24463009	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcggctgtatgaagcaggCgactacaaggctgttgtgca	10	8	14	9	2	0	1	0	1	0	0	0	2	0	1	0	3	4	6	0	3	4	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr22:24463009C>G	uc002zzi.1	+	16	2236	c.2109C>G	c.(2107-2109)GGC>GGG	p.G703G	CABIN1_uc002zzj.1_Silent_p.G653G|CABIN1_uc002zzl.1_Silent_p.G703G	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	703					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ATGAAGCAGGCGACTACAAGG	0.547													9	40					0	0	0	0	G	24463009	G	G	24463009	2	3	30	1	0	0	0	0	0	0	0	1	2540	755	27	3		3	CABIN1	22	24463009	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	4361720	24463009	26841557	63	6040											
DEPDC5	9681	broad.mit.edu	37	chr22	32154558	32154558	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctagttgtgaaccccaaaGtgttccctcacatcaagctt	11	11	7	12	0	2	1	2	1	0	0	3	1	3	1	3	0	3	4	3	0	4	4			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr22:32154558G>A	uc003als.2	+	3	227	c.85G>A	c.(85-87)GTG>ATG	p.V29M	DEPDC5_uc011als.1_Missense_Mutation_p.V29M|DEPDC5_uc011alu.1_Missense_Mutation_p.V29M|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.V29M|DEPDC5_uc003alr.1_Missense_Mutation_p.V29M|DEPDC5_uc011alt.1_Missense_Mutation_p.V29M	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	29					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						GAACCCCAAAGTGTTCCCTCA	0.378													19	62					0	0	0	0	A	32154558	A	A	32154558	3	1	30	1	0	0	0	0	1	0	0	0	4464	1029	36	4	91	4	DEPDC5	22	32154558	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	7691549	32154558	19150008	64	6041											
EP300	2033	broad.mit.edu	37	chr22	41546092	41546092	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagtgcagccttcacttcctGctgcaccttctgctgaccag	7	11	8	15	0	2	1	1	1	1	0	3	1	3	1	4	0	5	4	4	0	1	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr22:41546092G>A	uc003azl.3	+	14	3102	c.2707G>A	c.(2707-2709)GCT>ACT	p.A903T		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	903					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TTCACTTCCTGCTGCACCTTC	0.617			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				13	44					0	0	0	0	A	41546092	A	A	41546092	3	1	30	1	0	0	0	0	1	0	0	0	5172	1319	46	4	2761	4	EP300	22	41546092	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	9391534	41546092	9758474	65	6042											
TUBGCP6	85378	broad.mit.edu	37	chr22	50659169	50659169	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gttccaccgtggccgggtggGagccatgtctgacacagact	7	8	14	12	2	1	2	0	1	1	1	2	3	2	3	4	3	1	1	4	3	0	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr22:50659169G>A	uc003bkb.1	-	16	4131	c.3619C>T	c.(3619-3621)CCC>TCC	p.P1207S	TUBGCP6_uc003bka.1_Missense_Mutation_p.P294S|TUBGCP6_uc010har.1_Missense_Mutation_p.P1199S|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1207	7.|9 X 27 AA tandem repeats.				G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GGCCGGGTGGGAGCCATGTCT	0.622													16	67					0	0	0	0	A	50659169	A	A	50659169	3	1	30	1	0	0	0	0	1	0	0	0	16838	1174	41	2	1880	2	TUBGCP6	22	50659169	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	9113077	50659169	645397	66	6043											
LMF2	91289	broad.mit.edu	37	chr22	50943408	50943408	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgggctccacgtaggagtaCggcacctggagacaggtggg	8	5	17	11	3	0	1	0	0	0	1	1	3	1	2	3	6	1	4	3	6	2	2	rs139453267		TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chr22:50943408C>T	uc003blp.2	-	10	1291	c.1260G>A	c.(1258-1260)CCG>CCA	p.P420P	LMF2_uc010hba.2_Silent_p.P242P|LMF2_uc003blo.2_Silent_p.P395P	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	420						endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGTAGGAGTACGGCACCTGGA	0.687													8	20					0	0	0	0	T	50943408	T	T	50943408	2	4	30	1	0	0	0	0	0	0	0	1	8888	523	19	1		1	LMF2	22	50943408	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	284239	50943408	361158	67	6044											
CCDC120	90060	broad.mit.edu	37	chrX	48925109	48925109	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggactattccttggaccggGgcctgccccgcagtggcggt	4	9	15	13	3	0	0	0	0	0	0	1	2	1	2	5	6	1	1	5	6	1	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chrX:48925109G>A	uc010nik.2	+	10	1861	c.1354G>A	c.(1354-1356)GGC>AGC	p.G452S	CCDC120_uc011mmq.1_Missense_Mutation_p.G440S|CCDC120_uc004dmf.2_Missense_Mutation_p.G452S|CCDC120_uc010nil.2_Missense_Mutation_p.G452S|CCDC120_uc011mmr.1_Missense_Mutation_p.G452S|CCDC120_uc011mms.1_Missense_Mutation_p.G440S	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	452	Pro-rich.						protein binding			pancreas(1)	1						CTTGGACCGGGGCCTGCCCCG	0.716													12	35					0	0	0	0	A	48925109	A	A	48925109	3	1	30	1	0	0	0	0	1	0	0	0	2768	1232	43	4	1384	4	CCDC120	23	48925109	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08		48925109	106345451	68	6045											
CPXCR1	53336	broad.mit.edu	37	chrX	88008652	88008652	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacagagatccaaaaagaTcaacgagaagaagatctaaa	23	4	8	6	1	2	5	1	0	1	5	3	8	3	5	1	0	2	0	1	0	8	1			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chrX:88008652T>A	uc004efd.3	+	3	496	c.237T>A	c.(235-237)GAT>GAA	p.D79E	CPXCR1_uc004efc.3_Missense_Mutation_p.D79E	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	79						intracellular	zinc ion binding			ovary(3)	3						TCCAAAAAGATCAACGAGAAG	0.458													8	17					0	0	0	0	A	88008652	A	A	88008652	3	1	30	1	0	0	0	0	1	0	0	0	3851	1432	50	5	239	5	CPXCR1	23	88008652	Missense_Mutation	SNP	T	TCGA-BB-7863-01A-11D-2229-08	39083543	88008652	67261908	69	6046											
ZCCHC12	170261	broad.mit.edu	37	chrX	117959418	117959418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgacccaagtcaatggcGtcctgccagattggaatatg	10	9	12	10	1	1	2	1	1	0	1	2	3	2	3	3	3	1	1	3	3	4	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chrX:117959418G>A	uc004equ.2	+	4	684	c.211G>A	c.(211-213)GTC>ATC	p.V71I		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	71					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						agtcaatggcgtcctgccaga	0.055													22	58					0	0	0	0	A	117959418	A	A	117959418	3	1	30	1	0	0	0	0	1	0	0	0	17648	1145	40	1	213	1	ZCCHC12	23	117959418	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	29950766	117959418	37311142	70	6047											
DCAF12L2	340578	broad.mit.edu	37	chrX	125298805	125298805	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agaagagcagggaaccatggCcggtgcccacagtgatgatg	12	5	15	9	1	0	4	0	2	0	2	0	5	0	5	3	3	3	1	3	3	2	0			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chrX:125298805C>T	uc004euk.1	-	1	1130	c.1103G>A	c.(1102-1104)GGC>GAC	p.G368D		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	368	WD 4.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GGAACCATGGCCGGTGCCCAC	0.652													19	61					0	0	0	0	T	125298805	T	T	125298805	3	4	30	1	0	0	0	0	1	0	0	0	4282	739	26	4	292	4	DCAF12L2	23	125298805	Missense_Mutation	SNP	C	TCGA-BB-7863-01A-11D-2229-08	7339387	125298805	29971755	71	6048											
GABRQ	55879	broad.mit.edu	37	chrX	151815526	151815526	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgagaagttgtgggtccctGactgctactttctgaacagc	9	12	11	9	0	1	3	0	3	1	1	2	4	2	3	1	1	4	2	1	1	3	3			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chrX:151815526G>C	uc004ffp.1	+	4	444	c.424G>C	c.(424-426)GAC>CAC	p.D142H		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	142	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GTGGGTCCCTGACTGCTACTT	0.488													27	69					0	0	0	0	C	151815526	C	C	151815526	3	2	30	1	0	0	0	0	1	0	0	0	6209	1290	45	2	438	2	GABRQ	23	151815526	Missense_Mutation	SNP	G	TCGA-BB-7863-01A-11D-2229-08	26516721	151815526	3455034	72	6049											
PLXNA3	55558	broad.mit.edu	37	chrX	153695914	153695914	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacctgattcccgcggcagcCggcagctcccgcctcaacta	8	6	9	18	4	1	1	1	1	0	0	3	1	3	1	5	2	4	3	5	2	3	2			TCGA-BB-7863-01A-11D-2229-08	TCGA-BB-7863-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bf356d5-1259-4042-9860-2f793f5fe32c	b93c12cc-bb24-4437-b373-3842d878e488	g.chrX:153695914C>T	uc004flm.2	+	20	3641	c.3468C>T	c.(3466-3468)GCC>GCT	p.A1156A		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1156	IPT/TIG 4.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCGCGGCAGCCGGCAGCTCCC	0.662													8	9					0	0	0	0	T	153695914	T	T	153695914	2	4	30	1	0	0	0	0	0	0	0	1	12176	639	23	1		1	PLXNA3	23	153695914	Silent	SNP	C	TCGA-BB-7863-01A-11D-2229-08	1880388	153695914	1574646	73	6050											
VPS13D	55187	broad.mit.edu	37	chr1	12321060	12321060	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtccgggagccccagaacCcggtggaggcagtgggatgc	7	5	17	12	2	0	1	0	0	0	1	1	4	1	4	4	5	3	1	4	5	1	0			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:12321060C>T	uc001atv.2	+	12	1409	c.1268C>T	c.(1267-1269)CCC>CTC	p.P423L	VPS13D_uc001atw.2_Missense_Mutation_p.P423L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	423					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GCCCCAGAACCCGGTGGAGGC	0.562													50	137					0	0	0	0	T	12321060	T	T	12321060	3	4	31	1	0	0	0	0	1	0	0	0	17260	623	22	4	1310	4	VPS13D	1	12321060	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08		12321060	236929561	1	6051											
CELA2A	63036	broad.mit.edu	37	chr1	15793937	15793937	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacggccggtggcaggtgcaCggcatcgtcagcttcgggtc	5	7	17	12	5	1	0	1	0	0	0	4	1	1	0	1	6	2	4	1	6	0	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:15793937C>T	uc001awk.2	+	7	722	c.696C>T	c.(694-696)CAC>CAT	p.H232H		NM_033440	NP_254275	P08217	CEL2A_HUMAN	elastase 2A preproprotein	232	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						GGCAGGTGCACGGCATCGTCA	0.592													19	59					0	0	0	0	T	15793937	T	T	15793937	2	4	31	1	0	0	0	0	0	0	0	1	3226	535	19	1		1	CELA2A	1	15793937	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08	3472877	15793937	233456684	2	6052											
MACF1	23499	broad.mit.edu	37	chr1	39775248	39775248	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtgttatttctagggtcgaAcaatcttatcagaaggttat	11	16	9	5	1	3	1	1	0	2	1	4	2	3	1	0	2	1	2	0	2	7	5			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:39775248A>C	uc010ois.1	+	25	3016	c.2811A>C	c.(2809-2811)GAA>GAC	p.E937D	MACF1_uc001cda.1_Missense_Mutation_p.E845D|MACF1_uc001cdc.1_Missense_Mutation_p.E24D|MACF1_uc009vvq.1_5'UTR|MACF1_uc001cdb.1_Missense_Mutation_p.E24D	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	937					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTAGGGTCGAACAATCTTATC	0.408													20	63					0	0	0	0	C	39775248	C	C	39775248	3	2	31	1	0	0	0	0	1	0	0	0	9195	40	2	5	2901	5	MACF1	1	39775248	Missense_Mutation	SNP	A	TCGA-BB-7864-01A-11D-2229-08	23981311	39775248	209475373	3	6053											
UBE2Q1	55585	broad.mit.edu	37	chr1	154528354	154528360	+	Frame_Shift_Del	DEL	TATGTCC	-	-																															accagagtattccctttcttTatgtccaccagcctctccaa																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:154528354_154528360delTATGTCC	uc001fff.1	-	2	499_505	c.408_414delGGACATA	c.(406-414)GTGGACATAfs	p.V136fs		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	136_138							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCCCTTTCTTTATGTCCACCAGCCTCT	0.522													---	---	---								-	154528360	-	-	154528354	7	5	31	1	0	1	0	1	0	0	0	0	16937	1744	61	0	902	0	UBE2Q1	1	154528354	Frame_Shift_Del	DEL	TATGTCC	TCGA-BB-7864-01A-11D-2229-08	114753106	154528354	94722267	4	6054											
APCS	325	broad.mit.edu	37	chr1	159558139	159558139	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagttacatccaaagttatcGaaaagttcccggctccagtg	13	10	8	10	2	0	0	0	0	0	0	4	1	3	0	3	1	1	4	3	1	6	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:159558139G>A	uc001ftv.2	+	2	409	c.313G>A	c.(313-315)GAA>AAA	p.E105K		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	105	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					CAAAGTTATCGAAAAGTTCCC	0.423													27	69					0	0	0	0	A	159558139	A	A	159558139	3	1	31	1	0	0	0	0	1	0	0	0	767	1059	37	1	319	1	APCS	1	159558139	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	5029785	159558139	89692482	5	6055											
AVPR1B	553	broad.mit.edu	37	chr1	206224583	206224583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccactgtcctggtgctggCgaccgggggcaacctggctg	4	7	17	13	2	0	0	0	0	0	0	1	1	1	0	4	6	2	3	4	6	1	0			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:206224583C>T	uc001hds.2	+	1	301	c.143C>T	c.(142-144)GCG>GTG	p.A48V		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	48	Helical; Name=1; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CTGGTGCTGGCGACCGGGGGC	0.677													38	138					0	0	0	0	T	206224583	T	T	206224583	3	4	31	1	0	0	0	0	1	0	0	0	1234	768	27	1	145	1	AVPR1B	1	206224583	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	46666444	206224583	43026038	6	6056											
SPATA17	128153	broad.mit.edu	37	chr1	217856683	217856683	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtacctgaaagtcgtttcAgagaccaatgatgcaattag	14	10	10	7	1	1	3	1	2	0	1	2	5	1	3	2	0	2	3	2	0	5	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:217856683A>G	uc001hlh.1	+	5	401	c.375A>G	c.(373-375)TCA>TCG	p.S125S	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Silent_p.S125S	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	125						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		AAGTCGTTTCAGAGACCAATG	0.348													34	91					0	0	0	0	G	217856683	G	G	217856683	2	3	31	1	0	0	0	0	0	0	0	1	15068	175	7	5		5	SPATA17	1	217856683	Silent	SNP	A	TCGA-BB-7864-01A-11D-2229-08	11632100	217856683	31393938	7	6057											
ACTN2	88	broad.mit.edu	37	chr1	236902795	236902795	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagctgcggatcagcaaccGtcctgccttcatgccctccg	7	8	9	17	3	2	0	2	0	0	0	4	1	4	1	5	1	6	2	5	1	2	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:236902795G>A	uc001hyf.2	+	10	1274	c.1070G>A	c.(1069-1071)CGT>CAT	p.R357H	ACTN2_uc001hyg.2_Missense_Mutation_p.R149H|ACTN2_uc009xgi.1_Missense_Mutation_p.R357H|ACTN2_uc010pxu.1_Intron|ACTN2_uc001hyh.2_Missense_Mutation_p.R45H	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	357	Spectrin 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			ATCAGCAACCGTCCTGCCTTC	0.607													10	40					0	0	0	0	A	236902795	A	A	236902795	3	1	31	1	0	0	0	0	1	0	0	0	205	1145	40	1	1108	1	ACTN2	1	236902795	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	19046112	236902795	12347826	8	6058											
SDCCAG8	10806	broad.mit.edu	37	chr1	243504378	243504378	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaatattgcccaactggaggCccaggtggaaaaggttacaa	14	7	12	8	0	0	0	0	0	0	0	0	3	0	2	2	5	3	1	2	5	7	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:243504378C>T	uc001hzw.2	+	11	1415	c.1259C>T	c.(1258-1260)GCC>GTC	p.A420V	SDCCAG8_uc010pyk.1_Missense_Mutation_p.A275V|SDCCAG8_uc010pyl.1_Missense_Mutation_p.A232V|SDCCAG8_uc001hzx.2_Missense_Mutation_p.A232V	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	420	Potential.|Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		CAACTGGAGGCCCAGGTGGAA	0.373													13	37					0	0	0	0	T	243504378	T	T	243504378	3	4	31	1	0	0	0	0	1	0	0	0	14024	739	26	4	1301	4	SDCCAG8	1	243504378	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	6601583	243504378	5746243	9	6059											
CNST	163882	broad.mit.edu	37	chr1	246755211	246755211	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggaaaaagaagtccaagaaGcaaaaaagggactgctaaga	21	4	11	5	0	0	3	0	0	0	3	1	5	1	5	1	2	2	2	1	2	9	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr1:246755211G>T	uc001ibp.2	+	2	725	c.347G>T	c.(346-348)AGC>ATC	p.S116I	CNST_uc001ibo.3_Missense_Mutation_p.S116I	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	116					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						AGTCCAAGAAGCAAAAAAGGG	0.378													6	18					0.00116845	0.00119181	1	0	T	246755211	T	T	246755211	3	4	31	1	0	0	0	0	1	0	0	0	3649	971	34	4	349	4	CNST	1	246755211	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	3250833	246755211	2495410	10	6060											
CCDC85A	114800	broad.mit.edu	37	chr2	56419679	56419679	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgtttcctggatgatgAccggcagaaaggcaagaggg	10	8	15	8	1	0	4	0	2	0	2	1	5	1	5	2	4	1	4	2	4	2	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:56419679A>T	uc002rzn.2	+	2	846	c.344A>T	c.(343-345)GAC>GTC	p.D115V		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	115										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTGGATGATGACCGGCAGAAA	0.532													45	22					0	0	0	0	T	56419679	T	T	56419679	3	4	31	1	0	0	0	0	1	0	0	0	2872	275	10	5	350	5	CCDC85A	2	56419679	Missense_Mutation	SNP	A	TCGA-BB-7864-01A-11D-2229-08		56419679	186779694	11	6061											
C2orf51	200523	broad.mit.edu	37	chr2	88828764	88828764	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcgcaagttcaccagcacCtgccatttcacatatccagc	11	8	7	15	1	2	0	2	0	0	0	3	1	3	0	4	0	4	3	4	0	2	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:88828764C>T	uc002stb.1	+	4	457	c.315C>T	c.(313-315)ACC>ACT	p.T105T		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	105						nucleus				skin(1)	1						TCACCAGCACCTGCCATTTCA	0.592													24	122					0	0	0	0	T	88828764	T	T	88828764	2	4	31	1	0	0	0	0	0	0	0	1	2183	668	24	4		4	C2orf51	2	88828764	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08	32409085	88828764	154370609	12	6062											
LRP1B	53353	broad.mit.edu	37	chr2	141032097	141032097	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttcatagcgcgttggacaGacacattcaacacttccatc	11	10	6	14	2	2	1	2	0	0	1	4	2	3	2	2	1	2	1	2	1	2	5			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:141032097G>C	uc002tvj.1	-	85	14010	c.13038C>G	c.(13036-13038)GTC>GTG	p.V4346V		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4346	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCGTTGGACAGACACATTCAA	0.408										TSP Lung(27;0.18)			50	32					0	0	0	0	C	141032097	C	C	141032097	2	2	31	1	0	0	0	0	0	0	0	1	9005	929	33	2		2	LRP1B	2	141032097	Silent	SNP	G	TCGA-BB-7864-01A-11D-2229-08	52203333	141032097	102167276	13	6063											
NEB	4703	broad.mit.edu	37	chr2	152468860	152468860	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacagagccaatgggaaccCatcctatgcctctcagccac	11	7	7	16	0	1	1	1	0	1	1	3	2	2	2	5	1	5	0	5	1	4	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:152468860C>A	uc010fnx.2	-	74	11107	c.10916G>T	c.(10915-10917)TGG>TTG	p.W3639L		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3639	Nebulin 100.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AATGGGAACCCATCCTATGCC	0.458													30	17					4.31634e-10	4.94681e-10	1	0	A	152468860	A	A	152468860	3	1	31	1	0	0	0	0	1	0	0	0	10356	595	21	4	14461	4	NEB	2	152468860	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	11436763	152468860	90730513	14	6064											
TTN	7273	broad.mit.edu	37	chr2	179456400	179456400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgttttcagcttttacaCggaatctataggtctttcct	9	17	6	9	1	3	0	1	0	2	0	4	1	4	1	1	2	2	2	1	2	5	7			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:179456400C>T	uc010zfg.1	-	252	52666	c.52442G>A	c.(52441-52443)CGT>CAT	p.R17481H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R11176H|TTN_uc010zfi.1_Missense_Mutation_p.R11109H|TTN_uc010zfj.1_Missense_Mutation_p.R10984H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18408							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCTTTTACACGGAATCTATA	0.398													130	70					0	0	0	0	T	179456400	T	T	179456400	3	4	31	1	0	0	0	0	1	0	0	0	16803	536	19	1	48073	1	TTN	2	179456400	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	26987540	179456400	63742973	15	6065											
TMEFF2	23671	broad.mit.edu	37	chr2	192818509	192818509	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaggaccgggaacaacgtaTagaacactgtagtccttttt	13	10	9	9	2	0	1	0	0	0	1	1	3	1	3	2	2	3	2	2	2	6	5			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:192818509T>C	uc002utc.2	-	9	1318	c.924A>G	c.(922-924)CTA>CTG	p.L308L		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	308	Required for shedding.|Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			GAACAACGTATAGAACACTGT	0.443													33	22					0	0	0	0	C	192818509	C	C	192818509	2	2	31	1	0	0	0	0	0	0	0	1	16080	1393	49	5		5	TMEFF2	2	192818509	Silent	SNP	T	TCGA-BB-7864-01A-11D-2229-08	13362109	192818509	50380864	16	6066											
FN1	2335	broad.mit.edu	37	chr2	216246973	216246973	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaggctgactctctccgCttggattctgagcatagaca	9	10	10	12	1	2	4	0	2	2	2	4	5	3	5	2	2	1	3	2	2	1	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr2:216246973C>T	uc002vfa.2	-	32	5392	c.5126G>A	c.(5125-5127)AGC>AAC	p.S1709N	FN1_uc002vfb.2_Missense_Mutation_p.S1618N|FN1_uc002vfc.2_Missense_Mutation_p.S1618N|FN1_uc002vfd.2_Missense_Mutation_p.S1709N|FN1_uc002vfe.2_Missense_Mutation_p.S1618N|FN1_uc002vff.2_Missense_Mutation_p.S1618N|FN1_uc002vfg.2_Missense_Mutation_p.S1618N|FN1_uc002vfh.2_Missense_Mutation_p.S1618N|FN1_uc002vfi.2_Missense_Mutation_p.S1709N|FN1_uc002vfj.2_Missense_Mutation_p.S1709N|FN1_uc002vez.2_5'UTR|FN1_uc010zjp.1_Missense_Mutation_p.S336N|FN1_uc010fvc.1_Missense_Mutation_p.S71N|FN1_uc010fvd.1_Missense_Mutation_p.S71N	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTCTCTCCGCTTGGATTCTG	0.443													17	28					0	0	0	0	T	216246973	T	T	216246973	3	4	31	1	0	0	0	0	1	0	0	0	5994	797	28	4	2367	4	FN1	2	216246973	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	23428464	216246973	26952400	17	6067											
ITPR1	3708	broad.mit.edu	37	chr3	4687340	4687340	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacacaggaagaagcagcaCgtcttcctgagaaccacggg	14	4	12	11	2	1	2	0	1	1	2	2	5	2	3	2	2	4	2	2	2	4	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr3:4687340C>T	uc003bqa.2	+	10	1131	c.783C>T	c.(781-783)CAC>CAT	p.H261H	ITPR1_uc010hbz.2_Silent_p.H261H|ITPR1_uc010hca.1_Silent_p.H261H|ITPR1_uc011asu.1_Silent_p.H261H|ITPR1_uc010hcb.1_Silent_p.H261H	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	261	MIR 3.|Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGAAGCAGCACGTCTTCCTGA	0.547													14	8					0	0	0	0	T	4687340	T	T	4687340	2	4	31	1	0	0	0	0	0	0	0	1	7959	535	19	1		1	ITPR1	3	4687340	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08		4687340	193335090	18	6068											
TBC1D5	9779	broad.mit.edu	37	chr3	17255708	17255708	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaatacttacagattctttTctgcccatagttttgctgtg	9	18	6	8	0	2	1	0	0	2	1	2	1	2	1	1	0	4	2	1	0	5	9			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr3:17255708T>C	uc003cbf.2	-	18	3408	c.1743A>G	c.(1741-1743)AGA>AGG	p.R581R	TBC1D5_uc010heu.2_Silent_p.R168R|TBC1D5_uc010hev.2_Silent_p.R603R|TBC1D5_uc003cbe.2_Silent_p.R581R|TBC1D5_uc010hew.1_Silent_p.R555R	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	581						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						CAGATTCTTTTCTGCCCATAG	0.383													6	18					0	0	0	0	C	17255708	C	C	17255708	2	2	31	1	0	0	0	0	0	0	0	1	15689	1780	62	5		5	TBC1D5	3	17255708	Silent	SNP	T	TCGA-BB-7864-01A-11D-2229-08	12568368	17255708	180766722	19	6069											
KALRN	8997	broad.mit.edu	37	chr3	124281837	124281837	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctggtccgtaccaccgaaCggagcccgcccttggagggt	6	7	14	14	4	1	0	0	0	1	0	2	3	2	2	5	4	3	1	5	4	2	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr3:124281837C>T	uc003ehg.2	+	34	5204	c.5077C>T	c.(5077-5079)CGG>TGG	p.R1693W	KALRN_uc003ehi.2_Missense_Mutation_p.R66W	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1693	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TACCACCGAACGGAGCCCGCC	0.657													43	103					0	0	0	0	T	124281837	T	T	124281837	3	4	31	1	0	0	0	0	1	0	0	0	8014	527	19	1	5278	1	KALRN	3	124281837	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	107026129	124281837	73740593	20	6070											
SERPINI2	5276	broad.mit.edu	37	chr3	167189381	167189381	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtaagagtctcaccagctGaggtttcctgttgttttaaa	10	15	9	7	0	1	2	1	1	1	1	3	2	2	2	2	1	1	5	2	1	3	5			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr3:167189381G>A	uc003fer.1	-	1	300	c.242C>T	c.(241-243)TCA>TTA	p.S81L	SERPINI2_uc003fes.1_Missense_Mutation_p.S91L|SERPINI2_uc003fet.1_Missense_Mutation_p.S81L	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	81					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						CTCACCAGCTGAGGTTTCCTG	0.363													42	127					0	0	0	0	A	167189381	A	A	167189381	3	1	31	1	0	0	0	0	1	0	0	0	14184	1294	45	2	1007	2	SERPINI2	3	167189381	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	42907544	167189381	30833049	21	6071											
ABCF3	55324	broad.mit.edu	37	chr3	183911221	183911221	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccattgaggctctgggccGtgccctcaacaatttcaggg	8	9	12	12	1	3	1	2	1	1	0	3	2	3	1	3	3	2	1	3	3	2	2	rs150420700		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr3:183911221G>C	uc003fmz.2	+	20	2085	c.1952G>C	c.(1951-1953)CGT>CCT	p.R651P	ABCF3_uc003fna.2_Missense_Mutation_p.R645P|ABCF3_uc003fnb.2_Missense_Mutation_p.R332P	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	651	ABC transporter 2.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCTCTGGGCCGTGCCCTCAAC	0.592													37	174					0	0	0	0	C	183911221	C	C	183911221	3	2	31	1	0	0	0	0	1	0	0	0	67	1145	40	3	2030	3	ABCF3	3	183911221	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	16721840	183911221	14111209	22	6072											
JAKMIP1	152789	broad.mit.edu	37	chr4	6064140	6064140	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgggtcagctggcagaagcGcaggtcagcctcctctcggg	6	6	15	14	3	3	1	2	0	1	1	5	1	4	1	3	4	3	3	3	4	1	0			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr4:6064140G>A	uc003giu.3	-	10	1735	c.1459C>T	c.(1459-1461)CGC>TGC	p.R487C	JAKMIP1_uc010idb.1_Missense_Mutation_p.R487C|JAKMIP1_uc010idc.1_Missense_Mutation_p.R302C|JAKMIP1_uc010idd.1_Missense_Mutation_p.R487C|JAKMIP1_uc011bwc.1_Missense_Mutation_p.R322C|JAKMIP1_uc003giv.3_Missense_Mutation_p.R487C|JAKMIP1_uc010ide.2_Missense_Mutation_p.R487C	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	487	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TGGCAGAAGCGCAGGTCAGCC	0.532													17	64					0	0	0	0	A	6064140	A	A	6064140	3	1	31	1	0	0	0	0	1	0	0	0	7979	1087	38	1	1159	1	JAKMIP1	4	6064140	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08		6064140	185090136	23	6073											
ABCG2	9429	broad.mit.edu	37	chr4	89039301	89039301	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcctcctgagcaggcccGtggaacataagtcttcctga	10	8	11	12	1	1	2	0	2	1	0	3	3	3	3	4	3	2	1	4	3	3	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr4:89039301G>A	uc003hrg.2	-	7	1294	c.801C>T	c.(799-801)CAC>CAT	p.H267H	ABCG2_uc003hrh.2_Silent_p.H267H|ABCG2_uc003hrf.2_Silent_p.H137H	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	267	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	GAGCAGGCCCGTGGAACATAA	0.433													22	46					0	0	0	0	A	89039301	A	A	89039301	2	1	31	1	0	0	0	0	0	0	0	1	69	1136	40	1		1	ABCG2	4	89039301	Silent	SNP	G	TCGA-BB-7864-01A-11D-2229-08	82975161	89039301	102114975	24	6074											
NPY2R	4887	broad.mit.edu	37	chr4	156136031	156136031	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacagtgttccacatcatcGccatgtgctccacttttgcc	7	13	6	15	1	2	0	2	0	0	0	5	0	4	0	4	0	2	2	4	0	0	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr4:156136031G>A	uc003ioq.2	+	2	1435	c.940G>A	c.(940-942)GCC>ACC	p.A314T	NPY2R_uc003ior.2_Missense_Mutation_p.A314T	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	314	Helical; Name=7; (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				CCACATCATCGCCATGTGCTC	0.537													23	45					0	0	0	0	A	156136031	A	A	156136031	3	1	31	1	0	0	0	0	1	0	0	0	10663	1087	38	1	942	1	NPY2R	4	156136031	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	67096730	156136031	35018245	25	6075											
PCDHGC3	5098	broad.mit.edu	37	chr5	140857945	140857945	+	Frame_Shift_Del	DEL	G	-	-																															cggggaggcctgatgtcgccGcacctttaccatcaggtgta																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr5:140857945delG	uc003lkv.1	+	1	2377	c.2262delG	c.(2260-2262)CCGfs	p.P754fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Frame_Shift_Del_p.P754fs|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	754	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATGTCGCCGCACCTTTACC	0.642											OREG0016865	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	140857945	-	-	140857945	7	5	31	1	0	1	0	1	0	0	0	0	11623	1074	38	0	2264	0	PCDHGC3	5	140857945	Frame_Shift_Del	DEL	G	TCGA-BB-7864-01A-11D-2229-08		140857945	40057315	26	6076											
IRF4	3662	broad.mit.edu	37	chr6	401688	401688	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagagcaggatctactgggAcgggcccctggcgctgtgca	7	6	15	13	2	1	1	0	0	1	1	1	3	1	3	3	4	3	3	3	4	1	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:401688A>T	uc003msz.3	+	7	1123	c.1010A>T	c.(1009-1011)GAC>GTC	p.D337V	IRF4_uc010jne.1_Missense_Mutation_p.D337V|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.D336V|IRF4_uc003mtc.1_Missense_Mutation_p.D167V	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	337					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		ATCTACTGGGACGGGCCCCTG	0.597			T	IGH@	MM 								11	29					0	0	0	0	T	401688	T	T	401688	3	4	31	1	0	0	0	0	1	0	0	0	7871	275	10	5	1032	5	IRF4	6	401688	Missense_Mutation	SNP	A	TCGA-BB-7864-01A-11D-2229-08		401688	170713379	27	6077											
HIST1H1T	3010	broad.mit.edu	37	chr6	26108108	26108108	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctctacgtcgtagccagcagCggccaatgccttcttgagcg	7	9	11	14	4	2	1	0	1	2	0	3	1	2	1	3	1	6	2	3	1	3	4			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:26108108C>T	uc003ngj.2	-	1	257	c.214G>A	c.(214-216)GCT>ACT	p.A72T		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	72	H15.				cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						TAGCCAGCAGCGGCCAATGCC	0.527													29	69					0	0	0	0	T	26108108	T	T	26108108	3	4	31	1	0	0	0	0	1	0	0	0	7166	768	27	1	413	1	HIST1H1T	6	26108108	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	25706420	26108108	145006959	28	6078											
OR2H2	7932	broad.mit.edu	37	chr6	29556136	29556136	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcatccacccccgcctgTgctggcagctggcatctgtg	5	9	10	17	1	2	0	1	0	1	0	3	0	3	0	5	2	2	4	5	2	0	0			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:29556136T>C	uc003nmr.1	+	1	454	c.415T>C	c.(415-417)TGC>CGC	p.C139R	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	139	Helical; Name=4; (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCCCCGCCTGTGCTGGCAGCT	0.612													46	230					0	0	0	0	C	29556136	C	C	29556136	3	2	31	1	0	0	0	0	1	0	0	0	11056	1696	59	5	417	5	OR2H2	6	29556136	Missense_Mutation	SNP	T	TCGA-BB-7864-01A-11D-2229-08	3448028	29556136	141558931	29	6079											
STK19	8859	broad.mit.edu	37	chr6	31939881	31939881	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcacgaaggaggttgacacCaacgtggccaccggcgcccc	9	5	12	15	4	1	1	1	1	0	0	1	3	1	2	5	4	1	1	5	4	2	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:31939881C>T	uc003nyv.2	+	1	236	c.108C>T	c.(106-108)ACC>ACT	p.T36T	DOM3Z_uc003nyo.1_5'UTR|DOM3Z_uc003nyp.1_5'UTR|DOM3Z_uc003nyq.1_5'UTR|DOM3Z_uc003nyr.1_5'UTR|DOM3Z_uc003nys.1_5'Flank|DOM3Z_uc010jtl.1_5'UTR|STK19_uc003nyt.2_5'UTR|DOM3Z_uc003nyu.1_5'UTR|STK19_uc011dow.1_Silent_p.T36T|STK19_uc011dox.1_5'UTR|STK19_uc003nyw.2_Silent_p.T36T|STK19_uc010jtn.1_5'Flank	NM_032454	NP_115830	P49842	STK19_HUMAN	serine/threonine kinase 19 isoform 2	36						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(4)	4						AGGTTGACACCAACGTGGCCA	0.687													22	94					0	0	0	0	T	31939881	T	T	31939881	2	4	31	1	0	0	0	0	0	0	0	1	15358	581	21	4		4	STK19	6	31939881	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08	2383745	31939881	139175186	30	6080											
CUL9	23113	broad.mit.edu	37	chr6	43188224	43188224	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaatgagtacctgacaactCggatcgagcagaaccttgtt	12	9	11	9	2	0	3	0	2	0	1	2	6	0	5	2	2	4	3	2	2	4	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:43188224C>T	uc003ouk.2	+	32	6385	c.6310C>T	c.(6310-6312)CGG>TGG	p.R2104W	CUL9_uc003oul.2_Missense_Mutation_p.R2076W|CUL9_uc010jyk.2_Missense_Mutation_p.R1256W|CUL9_uc003oun.2_5'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	2104	RING-type 1.				ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CCTGACAACTCGGATCGAGCA	0.582													58	183					0	0	0	0	T	43188224	T	T	43188224	3	4	31	1	0	0	0	0	1	0	0	0	4078	875	31	1	6432	1	CUL9	6	43188224	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	11248343	43188224	127926843	31	6081											
SLC35F1	222553	broad.mit.edu	37	chr6	118228909	118228909	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgatcccccctgagcagcCgcagcagcagctgcagccgc	8	4	12	17	2	0	2	0	2	0	0	1	3	1	2	5	0	7	6	5	0	0	0			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:118228909C>T	uc003pxx.3	+	1	221	c.20C>T	c.(19-21)CCG>CTG	p.P7L		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	7					transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		CCTGAGCAGCCGCAGCAGCAG	0.741													7	23					0	0	0	0	T	118228909	T	T	118228909	3	4	31	1	0	0	0	0	1	0	0	0	14652	652	23	1	22	1	SLC35F1	6	118228909	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	75040685	118228909	52886158	32	6082											
CLVS2	134829	broad.mit.edu	37	chr6	123319012	123319012	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagacacgctgcaccaggaCatccaggaggtgagggatat	12	5	13	11	1	0	2	0	1	0	1	1	5	1	5	3	4	1	2	3	4	1	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:123319012C>A	uc003pzi.1	+	2	959	c.90C>A	c.(88-90)GAC>GAA	p.D30E		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	30					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TGCACCAGGACATCCAGGAGG	0.547													12	57					1.5842e-08	1.7564e-08	1	0	A	123319012	A	A	123319012	3	1	31	1	0	0	0	0	1	0	0	0	3587	477	17	4	92	4	CLVS2	6	123319012	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	5090103	123319012	47796055	33	6083											
MYCT1	80177	broad.mit.edu	37	chr6	153019122	153019122	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atagaatcaaactgctttttTtcgacatactggtttttctt	10	19	5	7	1	2	1	1	0	1	1	3	2	2	1	0	1	3	2	0	1	4	8			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr6:153019122T>C	uc003qpd.3	+	1	93	c.85T>C	c.(85-87)TTC>CTC	p.F29L	MYCT1_uc010kjc.1_Missense_Mutation_p.F29L|MYCT1_uc003qpc.3_Missense_Mutation_p.F29L	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	29						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		ACTGCTTTTTTTCGACATACT	0.333													6	15					0	0	0	0	C	153019122	C	C	153019122	3	2	31	1	0	0	0	0	1	0	0	0	10075	1841	64	5	87	5	MYCT1	6	153019122	Missense_Mutation	SNP	T	TCGA-BB-7864-01A-11D-2229-08	29700110	153019122	18095945	34	6084											
C7orf25	79020	broad.mit.edu	37	chr7	42950018	42950018	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaagatgatgtgagggttgCtatactgcactggctgctgg	9	11	14	7	0	0	3	0	2	0	1	0	3	0	3	0	3	4	5	0	3	3	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr7:42950018C>A	uc003thw.2	-	2	946	c.482G>T	c.(481-483)AGC>ATC	p.S161I	C7orf25_uc010kxq.2_Missense_Mutation_p.S161I|C7orf25_uc003thx.3_Missense_Mutation_p.S219I|C7orf25_uc010kxr.2_Missense_Mutation_p.S219I	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	161										skin(1)	1						GTGAGGGTTGCTATACTGCAC	0.498													28	60					7.26314e-15	8.41864e-15	1	0	A	42950018	A	A	42950018	3	1	31	1	0	0	0	0	1	0	0	0	2391	797	28	4	787	4	C7orf25	7	42950018	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08		42950018	116188645	35	6085											
AUTS2	26053	broad.mit.edu	37	chr7	69364472	69364472	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagagaaagaaaatgccgaaGgcactcagacaggtgaggaa	19	3	13	6	1	1	4	1	1	0	3	1	7	1	5	1	3	1	1	1	3	6	0			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr7:69364472G>A	uc003tvw.3	+	2	1253	c.510G>A	c.(508-510)AAG>AAA	p.K170K	AUTS2_uc003tvv.3_Silent_p.K170K|AUTS2_uc003tvx.3_Silent_p.K170K	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	170										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		AAATGCCGAAGGCACTCAGAC	0.517													19	35					0	0	0	0	A	69364472	A	A	69364472	2	1	31	1	0	0	0	0	0	0	0	1	1227	991	35	4		4	AUTS2	7	69364472	Silent	SNP	G	TCGA-BB-7864-01A-11D-2229-08	26414454	69364472	89774191	36	6086											
PON3	5446	broad.mit.edu	37	chr7	94993361	94993361	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgttctggtccaagaaccAcaatgtcattcacactaaag	14	10	6	11	0	3	1	2	0	1	1	4	1	4	1	2	1	1	1	2	1	5	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr7:94993361A>G	uc003unt.2	-	6	534	c.509T>C	c.(508-510)GTG>GCG	p.V170A	PON1_uc011kih.1_Intron|PON3_uc011kii.1_Missense_Mutation_p.V218A	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	170					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TCCAAGAACCACAATGTCATT	0.398													19	73					0	0	0	0	G	94993361	G	G	94993361	3	3	31	1	0	0	0	0	1	0	0	0	12305	159	6	5	571	5	PON3	7	94993361	Missense_Mutation	SNP	A	TCGA-BB-7864-01A-11D-2229-08	25628889	94993361	64145302	37	6087											
C7orf58	79974	broad.mit.edu	37	chr7	120773893	120773893	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggaattctttcacagaaGataagaacattgaaaaacca	19	8	7	7	0	2	4	1	1	1	3	2	5	2	5	1	1	2	1	1	1	6	4			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr7:120773893G>T	uc003vjq.3	+	13	2041	c.1594G>T	c.(1594-1596)GAT>TAT	p.D532Y	C7orf58_uc003vjr.1_Missense_Mutation_p.D532Y|C7orf58_uc003vjs.3_Missense_Mutation_p.D532Y|C7orf58_uc003vjt.3_Missense_Mutation_p.D312Y|C7orf58_uc010lkk.1_Missense_Mutation_p.D312Y	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	532						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TTTCACAGAAGATAAGAACAT	0.299													13	37					6.94344e-10	7.86924e-10	1	0	T	120773893	T	T	120773893	3	4	31	1	0	0	0	0	1	0	0	0	2416	942	33	2	1640	2	C7orf58	7	120773893	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	25780532	120773893	38364770	38	6088											
CDCA2	157313	broad.mit.edu	37	chr8	25364100	25364100	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaaaagaaaggatcttttgCgtcatgacccagatttgcat	13	12	9	7	1	2	4	1	2	1	2	2	5	2	5	1	1	2	1	1	1	3	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr8:25364100C>T	uc003xep.1	+	15	2397	c.1918C>T	c.(1918-1920)CGT>TGT	p.R640C	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.R625C|CDCA2_uc003xer.1_Missense_Mutation_p.R303C	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	640					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		GGATCTTTTGCGTCATGACCC	0.363													37	38					0	0	0	0	T	25364100	T	T	25364100	3	4	31	1	0	0	0	0	1	0	0	0	3101	768	27	1	1972	1	CDCA2	8	25364100	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08		25364100	120999922	39	6089											
PRKDC	5591	broad.mit.edu	37	chr8	48771464	48771464	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtgcttgaccagggccgtCaggggcgccatgcactcatg	7	8	14	12	2	2	1	2	1	0	0	2	1	2	1	3	3	2	2	3	3	0	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr8:48771464C>T	uc003xqi.2	-	48	6348	c.6291G>A	c.(6289-6291)CTG>CTA	p.L2097L	PRKDC_uc003xqj.2_Silent_p.L2097L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2097					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CCAGGGCCGTCAGGGGCGCCA	0.577								NHEJ					29	153					0	0	0	0	T	48771464	T	T	48771464	2	4	31	1	0	0	0	0	0	0	0	1	12583	813	29	2		2	PRKDC	8	48771464	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08	23407364	48771464	97592558	40	6090											
KCNB2	9312	broad.mit.edu	37	chr8	73849915	73849915	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcactgaggtttcagcGccttgtcagggaccttccaa	7	10	12	12	1	2	1	2	1	0	0	3	2	3	2	3	3	1	2	3	3	1	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr8:73849915G>T	uc003xzb.2	+	3	2913	c.2325G>T	c.(2323-2325)GCG>GCT	p.A775A		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	775	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGGTTTCAGCGCCTTGTCAGG	0.532													47	61					6.68952e-21	7.84289e-21	1	0	T	73849915	T	T	73849915	2	4	31	1	0	0	0	0	0	0	0	1	8052	1074	38	3		3	KCNB2	8	73849915	Silent	SNP	G	TCGA-BB-7864-01A-11D-2229-08	25078451	73849915	72514107	41	6091											
CSMD3	114788	broad.mit.edu	37	chr8	113277798	113277798	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcagtccattggctggtataCctgggtctccacaactgatt	8	13	9	11	0	2	1	1	1	1	0	4	1	3	1	3	3	2	2	3	3	3	4			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr8:113277798C>A	uc003ynu.2	-	60	9689	c.9530G>T	c.(9529-9531)GGT>GTT	p.G3177V	CSMD3_uc003yns.2_Missense_Mutation_p.G2379V|CSMD3_uc003ynt.2_Missense_Mutation_p.G3137V|CSMD3_uc011lhx.1_Missense_Mutation_p.G3008V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3177	Extracellular (Potential).|Sushi 24.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGCTGGTATACCTGGGTCTCC	0.428										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			129	97					5.60598e-63	6.80726e-63	1	0	A	113277798	A	A	113277798	3	1	31	1	0	0	0	0	1	0	0	0	3963	507	18	4	1641	4	CSMD3	8	113277798	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	39427883	113277798	33086224	42	6092											
PTCH1	5727	broad.mit.edu	37	chr9	98209339	98209339	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgtggtcagtctcagggtagCctgggcagagtccccctcgg	5	8	15	13	2	2	1	2	0	1	1	5	1	3	1	3	4	1	2	3	4	1	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr9:98209339C>T	uc004avk.3	-	23	4387	c.4199G>A	c.(4198-4200)GGC>GAC	p.G1400D	PTCH1_uc010mrn.2_Missense_Mutation_p.G192D|PTCH1_uc010mro.2_Missense_Mutation_p.G1249D|PTCH1_uc010mrp.2_Missense_Mutation_p.G1249D|PTCH1_uc010mrq.2_Missense_Mutation_p.G1249D|PTCH1_uc004avl.3_Missense_Mutation_p.G1249D|PTCH1_uc010mrr.2_Missense_Mutation_p.G1334D|PTCH1_uc004avm.3_Missense_Mutation_p.G1399D	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1400	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CTCAGGGTAGCCTGGGCAGAG	0.657									Basal_Cell_Nevus_syndrome				35	127					0	0	0	0	T	98209339	T	T	98209339	3	4	31	1	0	0	0	0	1	0	0	0	12792	739	26	4	148	4	PTCH1	9	98209339	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08		98209339	43004092	43	6093											
ZNF883	169834	broad.mit.edu	37	chr9	115759647	115759648	+	Frame_Shift_Ins	INS	-	A	A																															atagcaaaacagtttctgacINSattcattacattgatagggt																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr9:115759647_115759648insA	uc011lwy.1	-	5	2131_2132	c.892_893insT	c.(892-894)TGTfs	p.C298fs		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	298	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGTTTCTGACATTCATTACAT	0.376													---	---	---								A	115759648	A	A	115759647	7	5	31	1	0	1	1	0	0	0	0	0	18265	478	17	0	248	0	ZNF883	9	115759647	Frame_Shift_Ins	INS	-	TCGA-BB-7864-01A-11D-2229-08	17550308	115759647	25453784	44	6094											
TRIM32	22954	broad.mit.edu	37	chr9	119460090	119460091	+	Frame_Shift_Ins	INS	-	A	A																															tgctagaatgccccatctgcINSatggagtccttcacagaaga																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr9:119460090_119460091insA	uc004bjx.2	+	2	227_228	c.69_70insA	c.(67-72)TGCATGfs	p.C23fs	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Frame_Shift_Ins_p.C23fs	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	23_24	RING-type.				fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						GCCCCATCTGCATGGAGTCCTT	0.554									Bardet-Biedl_syndrome				---	---	---								A	119460091	A	A	119460090	7	5	31	1	0	1	1	0	0	0	0	0	16573	718	25	0	71	0	TRIM32	9	119460090	Frame_Shift_Ins	INS	-	TCGA-BB-7864-01A-11D-2229-08	3700443	119460090	21753341	45	6095											
NOTCH1	4851	broad.mit.edu	37	chr9	139418227	139418228	+	Frame_Shift_Ins	INS	-	C	C																															gcgtgagcaggtcgcaggtgINScccccgttgcggcaggggtt																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr9:139418227_139418228insC	uc004chz.2	-	3	344_345	c.344_345insG	c.(343-345)GGCfs	p.G115fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	115	Extracellular (Potential).|EGF-like 3.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGTCGCAGGTGCCCCCGTTGCG	0.688			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								C	139418228	C	C	139418227	7	5	31	1	0	1	1	0	0	0	0	0	10601	1306	46	0	7450	0	NOTCH1	9	139418227	Frame_Shift_Ins	INS	-	TCGA-BB-7864-01A-11D-2229-08	19958137	139418227	1795204	46	6096											
MKX	283078	broad.mit.edu	37	chr10	27964468	27964468	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acctttcacccttattggatCcgttttccagagtgtctgta	7	16	7	11	1	2	1	1	0	1	1	4	2	4	2	4	1	0	2	4	1	2	6			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:27964468C>T	uc001ity.3	-	6	1079	c.854G>A	c.(853-855)GGA>GAA	p.G285E	MKX_uc001itx.3_Missense_Mutation_p.G285E	NM_173576	NP_775847	Q8IYA7	MKX_HUMAN	mohawk homeobox	285					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTATTGGATCCGTTTTCCAG	0.378													8	30					0	0	0	0	T	27964468	T	T	27964468	3	4	31	1	0	0	0	0	1	0	0	0	9663	855	30	2	212	2	MKX	10	27964468	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08		27964468	107570279	47	6097											
CCAR1	55749	broad.mit.edu	37	chr10	70520917	70520919	+	In_Frame_Del	DEL	GAT	-	-																															ctgaaaaagaagaggatgagGatgatgataggaaatctgaa																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:70520917_70520919delGAT	uc001joo.2	+	16	2193_2195	c.2074_2076delGAT	c.(2074-2076)GATdel	p.D694del	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_In_Frame_Del_p.D499del|CCAR1_uc009xpx.1_In_Frame_Del_p.D668del|CCAR1_uc001jon.1_In_Frame_Del_p.D640del|CCAR1_uc010qiz.1_In_Frame_Del_p.D679del|CCAR1_uc010qja.1_In_Frame_Del_p.D679del|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	694	Glu-rich.				apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						AGAGGATGAGGATGATGATAGGA	0.34													---	---	---								-	70520919	-	-	70520917	7	5	31	1	0	1	0	1	0	0	0	0	2742	1174	41	0	2132	0	CCAR1	10	70520917	In_Frame_Del	DEL	GAT	TCGA-BB-7864-01A-11D-2229-08	42556449	70520917	65013830	48	6098											
CHUK	1147	broad.mit.edu	37	chr10	101989276	101989276	+	Frame_Shift_Del	DEL	G	-	-																															ccgcgcccggccgcagccccGggggccgctccatggggcgg																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr10:101989276delG	uc001kqp.2	-	1	69	c.14delC	c.(13-15)CCGfs	p.P5fs		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	5					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		ccgcagccccgggggccgcTC	0.557													---	---	---								-	101989276	-	-	101989276	7	5	31	1	0	1	0	1	0	0	0	0	3431	1116	39	0	2307	0	CHUK	10	101989276	Frame_Shift_Del	DEL	G	TCGA-BB-7864-01A-11D-2229-08	31468359	101989276	33545471	49	6099											
TRPM5	29850	broad.mit.edu	37	chr11	2444230	2444231	+	Frame_Shift_Ins	INS	-	G	G																															cgccggtcttcagcatccccINSggggcttccgggacgggggc																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:2444230_2444231insG	uc001lwm.3	-	1	45_46	c.36_37insC	c.(34-39)CCCGGGfs	p.P12fs	TRPM5_uc010qxl.1_Frame_Shift_Ins_p.P12fs|TRPM5_uc009ydn.2_Frame_Shift_Ins_p.P12fs	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	12_13	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TCAGCATCCCCGGGGCTTCCGG	0.668													---	---	---								G	2444231	G	G	2444230	7	5	31	1	0	1	1	0	0	0	0	0	16656	652	23	0	3556	0	TRPM5	11	2444230	Frame_Shift_Ins	INS	-	TCGA-BB-7864-01A-11D-2229-08		2444230	132562286	50	6100											
C11orf41	25758	broad.mit.edu	37	chr11	33667394	33667394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgcacatgctgctggaggagGccttcagcctggcatccgcg	6	8	14	13	2	1	0	1	0	0	0	2	2	2	2	3	4	4	4	3	4	0	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:33667394G>A	uc001mup.3	+	16	4823	c.4699G>A	c.(4699-4701)GCC>ACC	p.A1567T		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1561						integral to membrane				ovary(2)	2						GCTGGAGGAGGCCTTCAGCCT	0.657													11	33					0	0	0	0	A	33667394	A	A	33667394	3	1	31	1	0	0	0	0	1	0	0	0	1646	1203	42	4	4761	4	C11orf41	11	33667394	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	31223164	33667394	101339122	51	6101											
ABTB2	25841	broad.mit.edu	37	chr11	34182507	34182507	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccctcggtcaccagctcctcGttgtactcctcctctctgat	4	13	6	18	2	2	1	1	1	1	0	8	1	5	1	5	1	2	3	5	1	1	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:34182507G>A	uc001mvl.1	-	11	2012	c.1782C>T	c.(1780-1782)AAC>AAT	p.N594N		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	594							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				CCAGCTCCTCGTTGTACTCCT	0.597													14	46					0	0	0	0	A	34182507	A	A	34182507	2	1	31	1	0	0	0	0	0	0	0	1	103	1136	40	1		1	ABTB2	11	34182507	Silent	SNP	G	TCGA-BB-7864-01A-11D-2229-08	515113	34182507	100824009	52	6102											
F2	2147	broad.mit.edu	37	chr11	46741250	46741250	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacccccccaccgccttacAgtgttcctggctcctcagca	6	9	7	19	1	1	1	1	1	0	0	3	1	3	1	7	1	2	3	7	1	1	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:46741250A>G	uc001ndf.3	+	2	123	c.80_splice	c.e2-2	p.V27_splice	F2_uc001ndg.3_Splice_Site	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein						activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	ACCGCCTTACAGTGTTCCTGG	0.647													7	18					0	0	0	0	G	46741250	G	G	46741250	5	3	31	1	0	0	0	0	0	0	1	0	5367	202	7	5	84	5	F2	11	46741250	Splice_Site	SNP	A	TCGA-BB-7864-01A-11D-2229-08	12558743	46741250	88265266	53	6103											
OR4A15	81328	broad.mit.edu	37	chr11	55135884	55135884	+	Frame_Shift_Del	DEL	G	-	-																															tgtgttcttatgctgttggcGgcctggattggaggctttct																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:55135884delG	uc010rif.1	+	1	525	c.525delG	c.(523-525)GCGfs	p.A175fs		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	175	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGCTGTTGGCGGCCTGGATTG	0.438													---	---	---								-	55135884	-	-	55135884	7	5	31	1	0	1	0	1	0	0	0	0	11094	1103	39	0	527	0	OR4A15	11	55135884	Frame_Shift_Del	DEL	G	TCGA-BB-7864-01A-11D-2229-08	8394634	55135884	79870632	54	6104											
OR9Q1	219956	broad.mit.edu	37	chr11	57947810	57947810	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaacaaggaagtgaaggaGgccctgagaaaaattctcaa	18	5	12	6	0	1	2	1	2	1	1	2	6	1	5	1	4	1	0	1	4	7	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:57947810G>T	uc001nmj.2	+	3	1210	c.894G>T	c.(892-894)GAG>GAT	p.E298D		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				AAGTGAAGGAGGCCCTGAGAA	0.473													11	33					1.05317e-09	1.18048e-09	1	0	T	57947810	T	T	57947810	3	4	31	1	0	0	0	0	1	0	0	0	11309	991	35	4	896	4	OR9Q1	11	57947810	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	2811926	57947810	77058706	55	6105											
PPP2R5B	5526	broad.mit.edu	37	chr11	64695279	64695279	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactctgccactcagatctcAgtgaatatcttccggactct	10	12	6	13	1	5	2	2	1	4	1	7	3	6	3	2	1	2	0	2	1	3	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:64695279A>T	uc001oby.2	+	4	987	c.402A>T	c.(400-402)TCA>TCT	p.S134S	PPP2R5B_uc001obz.2_Silent_p.S134S	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	134					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						CTCAGATCTCAGTGAATATCT	0.463													15	50					0	0	0	0	T	64695279	T	T	64695279	2	4	31	1	0	0	0	0	0	0	0	1	12453	175	7	5		5	PPP2R5B	11	64695279	Silent	SNP	A	TCGA-BB-7864-01A-11D-2229-08	6747469	64695279	70311237	56	6106											
NCAPD3	23310	broad.mit.edu	37	chr11	134023217	134023217	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagtccgtggtgtcccgaTgtaactgacccctgctccaa	7	9	11	14	3	0	1	0	1	0	0	3	3	3	2	5	2	2	2	5	2	2	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr11:134023217T>G	uc001qhd.1	-	33	4900	c.4294A>C	c.(4294-4296)ATC>CTC	p.I1432L	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA|NCAPD3_uc001qhc.1_Missense_Mutation_p.I382L	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1432					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		GGTGTCCCGATGTAACTGACC	0.527													52	202					0	0	0	0	G	134023217	G	G	134023217	3	3	31	1	0	0	0	0	1	0	0	0	10260	1464	51	5	214	5	NCAPD3	11	134023217	Missense_Mutation	SNP	T	TCGA-BB-7864-01A-11D-2229-08	69327938	134023217	983299	57	6107											
CACNA1C	775	broad.mit.edu	37	chr12	2595423	2595423	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgctacaaccaggagggcaTagcaggtaagaggggcaggc	12	4	16	9	0	0	1	0	0	0	1	0	2	0	2	1	6	4	5	1	6	4	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:2595423T>C	uc009zdu.1	+	6	1224	c.911T>C	c.(910-912)ATA>ACA	p.I304T	CACNA1C_uc009zdv.1_Missense_Mutation_p.I304T|CACNA1C_uc001qkb.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkc.2_Missense_Mutation_p.I304T|CACNA1C_uc001qke.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkf.2_Missense_Mutation_p.I304T|CACNA1C_uc001qjz.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkd.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkg.2_Missense_Mutation_p.I304T|CACNA1C_uc009zdw.1_Missense_Mutation_p.I304T|CACNA1C_uc001qkh.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkl.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkn.2_Missense_Mutation_p.I304T|CACNA1C_uc001qko.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkp.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkr.2_Missense_Mutation_p.I304T|CACNA1C_uc001qku.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkq.2_Missense_Mutation_p.I304T|CACNA1C_uc001qks.2_Missense_Mutation_p.I304T|CACNA1C_uc001qkt.2_Missense_Mutation_p.I304T|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_Missense_Mutation_p.I40T|CACNA1C_uc001qkj.1_Missense_Mutation_p.I40T|CACNA1C_uc001qkk.1_Missense_Mutation_p.I40T|CACNA1C_uc001qkm.1_Missense_Mutation_p.I40T	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	304	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CAGGAGGGCATAGCAGGTAAG	0.587													13	57					0	0	0	0	C	2595423	C	C	2595423	3	2	31	1	0	0	0	0	1	0	0	0	2552	1406	49	5	933	5	CACNA1C	12	2595423	Missense_Mutation	SNP	T	TCGA-BB-7864-01A-11D-2229-08		2595423	131256472	58	6108											
ERP27	121506	broad.mit.edu	37	chr12	15068553	15068566	+	Frame_Shift_Del	DEL	TTTAGTTTGAAAAA	-	-																															aagctggcagttgagactccTttagtttgaaaaatgatatc																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:15068553_15068566delTTTAGTTTGAAAAA	uc001rco.2	-	6	652_665	c.631_644delTTTTTCAAACTAAA	c.(631-645)TTTTTCAAACTAAAGfs	p.F211fs		NM_152321	NP_689534	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27 kDa precursor	211_215						endoplasmic reticulum lumen				breast(1)	1						TTGAGACTCCTTTAGTTTGAAAAATGATATCACC	0.421													---	---	---								-	15068566	-	-	15068553	7	5	31	1	0	1	0	1	0	0	0	0	5265	1609	56	0	185	0	ERP27	12	15068553	Frame_Shift_Del	DEL	TTTAGTTTGAAAAA	TCGA-BB-7864-01A-11D-2229-08	12473130	15068553	118783342	59	6109											
NCKAP1L	3071	broad.mit.edu	37	chr12	54902309	54902309	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgcccatgagatgctgcatgGgcatgggtgagttaaggcga	9	9	16	7	1	0	2	0	2	0	1	0	4	0	2	1	3	3	4	1	3	1	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:54902309G>A	uc001sgc.3	+	5	579	c.500G>A	c.(499-501)GGG>GAG	p.G167E	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.G117E	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	167					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						ATGCTGCATGGGCATGGGTGA	0.428													75	183					0	0	0	0	A	54902309	A	A	54902309	3	1	31	1	0	0	0	0	1	0	0	0	10276	1232	43	4	518	4	NCKAP1L	12	54902309	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	39833756	54902309	78949586	60	6110											
MARCH9	92979	broad.mit.edu	37	chr12	58149573	58149573	+	Frame_Shift_Del	DEL	C	-	-																															cgcccgcgccgccgctgccgCccccgggcgcgctggacgcc																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:58149573delC	uc001spx.1	+	1	674	c.262delC	c.(262-264)CCCfs	p.P88fs	MARCH9_uc001spy.2_5'Flank	NM_138396	NP_612405	Q86YJ5	MARH9_HUMAN	membrane-associated RING-CH protein IX	88	Pro-rich.					Golgi membrane|Golgi stack|integral to membrane|lysosomal membrane|trans-Golgi network	ligase activity|zinc ion binding				0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			gccgctgccgcccccgggcgc	0.507													---	---	---								-	58149573	-	-	58149573	7	5	31	1	0	1	0	1	0	0	0	0	9361	739	26	0	264	0	MARCH9	12	58149573	Frame_Shift_Del	DEL	C	TCGA-BB-7864-01A-11D-2229-08	3247264	58149573	75702322	61	6111											
PPTC7	160760	broad.mit.edu	37	chr12	110977626	110977626	+	Splice_Site	DEL	C	-	-																															gctaacctttgagttaattaCctttaacttttttagctcct																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:110977626delC	uc001trh.1	-	4	954	c.726_splice	c.e4+1	p.K242_splice		NM_139283	NP_644812	Q8NI37	PPTC7_HUMAN	T-cell activation protein phosphatase 2C								metal ion binding|phosphoprotein phosphatase activity				0						GAGTTAATTACCTTTAACTTT	0.393													---	---	---								-	110977626	-	-	110977626	8	5	31	1	0	1	0	1	0	0	1	0	12473	521	18	0	199	0	PPTC7	12	110977626	Splice_Site	DEL	C	TCGA-BB-7864-01A-11D-2229-08	52828053	110977626	22874269	62	6112											
SBNO1	55206	broad.mit.edu	37	chr12	123782568	123782568	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttcttagccgcacgatctgCatcttcacgtttgtgccact	6	14	8	13	3	4	0	1	0	3	0	4	1	4	0	2	0	3	4	2	0	1	4			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:123782568C>T	uc010tap.1	-	30	3996	c.3996G>A	c.(3994-3996)ATG>ATA	p.M1332I	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.M1331I|SBNO1_uc010taq.1_Missense_Mutation_p.M283I	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1332							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GCACGATCTGCATCTTCACGT	0.433													30	100					0	0	0	0	T	123782568	T	T	123782568	3	4	31	1	0	0	0	0	1	0	0	0	13927	710	25	4	193	4	SBNO1	12	123782568	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	12804942	123782568	10069327	63	6113											
PIWIL1	9271	broad.mit.edu	37	chr12	130847589	130847589	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgcccagccggatcatcGtgtaccgcgatggcgtagga	9	7	13	12	5	1	0	1	0	0	0	2	3	1	2	3	3	3	2	3	3	2	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr12:130847589G>A	uc001uik.2	+	18	2185	c.2095G>A	c.(2095-2097)GTG>ATG	p.V699M	PIWIL1_uc001uij.1_Missense_Mutation_p.V699M	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	699	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CCGGATCATCGTGTACCGCGA	0.488													27	50					0	0	0	0	A	130847589	A	A	130847589	3	1	31	1	0	0	0	0	1	0	0	0	12012	1145	40	1	2161	1	PIWIL1	12	130847589	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	7065021	130847589	3004306	64	6114											
DCLK1	9201	broad.mit.edu	37	chr13	36402442	36402442	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcatactctctagcagtcGatctgcgaagagaaagttca	13	9	10	9	2	3	1	1	0	2	1	5	5	3	1	0	0	4	3	0	0	4	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr13:36402442G>T	uc001uvf.2	-	9	1465	c.1232C>A	c.(1231-1233)TCG>TAG	p.S411*	DCLK1_uc001uve.3_Nonsense_Mutation_p.S104*|DCLK1_uc010teh.1_Nonsense_Mutation_p.S104*|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	411	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TCTAGCAGTCGATCTGCGAAG	0.328													11	6					8.00594e-06	8.41862e-06	1	0	T	36402442	T	T	36402442	4	4	31	1	0	0	0	0	0	1	0	0	4308	1059	37	3	997	3	DCLK1	13	36402442	Nonsense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08		36402442	78767436	65	6115											
CCNA1	8900	broad.mit.edu	37	chr13	37011963	37011963	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggatgtgtatgaagtagaCaccggcacactcaagtcaga	14	7	12	8	1	2	3	2	1	0	2	2	5	2	4	1	2	0	3	1	2	4	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr13:37011963C>T	uc001uvr.3	+	3	845	c.495C>T	c.(493-495)GAC>GAT	p.D165D	CCNA1_uc010teo.1_Silent_p.D121D|CCNA1_uc010abq.2_Silent_p.D121D|CCNA1_uc010abp.2_Silent_p.D121D|CCNA1_uc001uvs.3_Silent_p.D164D|CCNA1_uc010abr.2_Intron	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	165					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		ATGAAGTAGACACCGGCACAC	0.488													30	47					0	0	0	0	T	37011963	T	T	37011963	2	4	31	1	0	0	0	0	0	0	0	1	2924	477	17	4		4	CCNA1	13	37011963	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08	609521	37011963	78157915	66	6116											
AHNAK2	113146	broad.mit.edu	37	chr14	105410834	105410835	+	Missense_Mutation	DNP	CC	AA	AA																															ctccatggacttccctggggCcgataccctgaatgacggca																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr14:105410834_105410835CC>AA	uc010axc.1	-	7	11073_11074	c.10953_10954GG>TT	c.(10951-10956)TCGGCC>TCTTCC	p.A3652S	AHNAK2_uc001ypx.2_Missense_Mutation_p.A3552S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3652						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTCCCTGGGGCCGATACCCTGA	0.584													77	160					0	0	0	0	AA	105410835	AA	AA	105410834	3	1	31	1	0	0	0	0	1	0	0	0	415	739	26	4	6437	4	AHNAK2	14	105410834	Missense_Mutation	DNP	CC	TCGA-BB-7864-01A-11D-2229-08		105410834	1938706	67	6117											
AHNAK2	113146	broad.mit.edu	37	chr14	105416396	105416396	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcacactgtccagcttggCtcctggagcctcgacgtcca	6	8	10	17	3	0	0	0	0	0	0	4	2	3	1	5	2	2	3	5	2	0	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr14:105416396C>A	uc010axc.1	-	7	5512	c.5392G>T	c.(5392-5394)GCC>TCC	p.A1798S	AHNAK2_uc001ypx.2_Missense_Mutation_p.A1698S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1798						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCCAGCTTGGCTCCTGGAGCC	0.627													12	57					2.31682e-05	2.41139e-05	1	0	A	105416396	A	A	105416396	3	1	31	1	0	0	0	0	1	0	0	0	415	797	28	4	11999	4	AHNAK2	14	105416396	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	5562	105416396	1933144	68	6118											
MAP1A	4130	broad.mit.edu	37	chr15	43814461	43814461	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcccactgagaagattgtgCgtgtgctttttccaggaaat	10	13	10	8	1	0	2	0	1	0	2	2	4	2	3	2	1	2	1	2	1	2	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr15:43814461C>T	uc001zrt.2	+	4	1257	c.790C>T	c.(790-792)CGT>TGT	p.R264C		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	264						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GAAGATTGTGCGTGTGCTTTT	0.542													16	46					0	0	0	0	T	43814461	T	T	43814461	3	4	31	1	0	0	0	0	1	0	0	0	9280	768	27	1	792	1	MAP1A	15	43814461	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08		43814461	58716931	69	6119											
SH2D7	646892	broad.mit.edu	37	chr15	78390833	78390833	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcacagtggtccccgacaaGgccgccagcccccgctcttc	6	6	9	20	3	2	0	1	0	1	0	4	1	3	0	6	2	1	1	6	2	1	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr15:78390833G>A	uc010blb.1	+	4	540	c.540G>A	c.(538-540)AAG>AAA	p.K180K		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	180											0						TCCCCGACAAGGCCGCCAGCC	0.602													18	34					0	0	0	0	A	78390833	A	A	78390833	2	1	31	1	0	0	0	0	0	0	0	1	14304	991	35	4		4	SH2D7	15	78390833	Silent	SNP	G	TCGA-BB-7864-01A-11D-2229-08	34576372	78390833	24140559	70	6120											
FANCI	55215	broad.mit.edu	37	chr15	89857856	89857856	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccttaggccagagttcttcGggaaaccaagccaatcccta	11	8	8	14	1	1	1	0	0	1	1	3	2	2	2	5	2	2	1	5	2	5	4			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr15:89857856G>T	uc010bnp.1	+	36	3824	c.3734G>T	c.(3733-3735)CGG>CTG	p.R1245L	FANCI_uc002bnm.1_Missense_Mutation_p.R1185L|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.R1005L|FANCI_uc002bnq.1_Missense_Mutation_p.R658L	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1245					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					AGAGTTCTTCGGGAAACCAAG	0.378								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				18	48					1.87028e-06	1.98717e-06	1	0	T	89857856	T	T	89857856	3	4	31	1	0	0	0	0	1	0	0	0	5701	1116	39	3	3872	3	FANCI	15	89857856	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	11467023	89857856	12673536	71	6121											
ACSM2A	123876	broad.mit.edu	37	chr16	20494425	20494425	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcgcagttcctgtcccatGacccagaacagctcaccaag	10	7	7	17	1	1	2	1	1	0	1	4	2	3	2	5	0	2	3	5	0	2	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr16:20494425G>A	uc010bwe.2	+	14	1794	c.1555G>A	c.(1555-1557)GAC>AAC	p.D519N	ACSM2A_uc002dhf.3_Missense_Mutation_p.D519N|ACSM2A_uc002dhg.3_Missense_Mutation_p.D519N|ACSM2A_uc010vay.1_Missense_Mutation_p.D440N|ACSM2A_uc002dhh.3_Missense_Mutation_p.D149N	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	519					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CCTGTCCCATGACCCAGAACA	0.522													34	81					0	0	0	0	A	20494425	A	A	20494425	3	1	31	1	0	0	0	0	1	0	0	0	183	1290	45	2	1601	2	ACSM2A	16	20494425	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08		20494425	69860328	72	6122											
SRCAP	10847	broad.mit.edu	37	chr16	30734936	30734936	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagctgcccccttgaccatCtcttctcctctccacgtgcc	4	11	7	19	1	3	1	0	1	3	0	6	2	3	2	6	1	3	1	6	1	0	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr16:30734936C>G	uc002dze.1	+	25	4576	c.4191C>G	c.(4189-4191)ATC>ATG	p.I1397M	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.I1192M|SRCAP_uc010bzz.1_Missense_Mutation_p.I967M	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1397	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CCTTGACCATCTCTTCTCCTC	0.567													43	137					0	0	0	0	G	30734936	G	G	30734936	3	3	31	1	0	0	0	0	1	0	0	0	15201	903	32	2	4281	2	SRCAP	16	30734936	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	10240511	30734936	59619817	73	6123											
PHKB	5257	broad.mit.edu	37	chr16	47733262	47733262	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagccaaacaatgatgacccGtgtctgattagctagtgggg	12	9	12	8	1	1	3	0	3	1	0	1	3	1	3	2	2	3	1	2	2	5	2	rs146134171	byFrequency	TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr16:47733262G>A	uc002eev.3	+	31	3319	c.3267G>A	c.(3265-3267)CCG>CCA	p.P1089P	PHKB_uc002eeu.3_Silent_p.P1082P|PHKB_uc002eew.3_Silent_p.P330P	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	1089					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				ATGATGACCCGTGTCTGATTA	0.463													36	123					0	0	0	0	A	47733262	A	A	47733262	2	1	31	1	0	0	0	0	0	0	0	1	11900	1132	40	1		1	PHKB	16	47733262	Silent	SNP	G	TCGA-BB-7864-01A-11D-2229-08	16998326	47733262	42621491	74	6124											
SLC7A6	9057	broad.mit.edu	37	chr16	68330382	68330382	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttggacagctctacctccGctggaaggagcccaagcggc	8	7	13	13	2	1	0	0	0	1	0	2	3	2	3	3	4	4	3	3	4	3	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr16:68330382G>A	uc002evt.1	+	10	1544	c.1235G>A	c.(1234-1236)CGC>CAC	p.R412H	SLC7A6_uc002evu.1_Missense_Mutation_p.R412H|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_001076785	NP_001070253	Q92536	YLAT2_HUMAN	solute carrier family 7 (cationic amino acid	412	Cytoplasmic (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		CTCTACCTCCGCTGGAAGGAG	0.577													46	132					0	0	0	0	A	68330382	A	A	68330382	3	1	31	1	0	0	0	0	1	0	0	0	14765	1087	38	1	1261	1	SLC7A6	16	68330382	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	20597120	68330382	22024371	75	6125											
CDH13	1012	broad.mit.edu	37	chr16	83711944	83711944	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcactgtcctggatgtcaaCgagggcccagtcttctaccc	8	10	9	14	1	4	0	2	0	2	0	5	2	5	1	3	2	2	0	3	2	2	2	rs147140848	by1000genomes	TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr16:83711944C>T	uc002fgx.2	+	10	1536	c.1416C>T	c.(1414-1416)AAC>AAT	p.N472N	CDH13_uc010vns.1_Silent_p.N519N|CDH13_uc010vnt.1_Silent_p.N218N|CDH13_uc010vnu.1_Silent_p.N433N	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	472	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TGGATGTCAACGAGGGCCCAG	0.602													18	96					0	0	0	0	T	83711944	T	T	83711944	2	4	31	1	0	0	0	0	0	0	0	1	3114	535	19	1		1	CDH13	16	83711944	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08	15381562	83711944	6642809	76	6126											
PFAS	5198	broad.mit.edu	37	chr17	8170160	8170160	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctgaagcgttaccgggatGctggcctccattgcctggag	6	10	14	11	2	0	1	0	1	0	0	1	3	1	3	4	3	5	3	4	3	2	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:8170160G>T	uc002gkr.2	+	23	3052	c.2911G>T	c.(2911-2913)GCT>TCT	p.A971S	PFAS_uc010vuv.1_Missense_Mutation_p.A547S|PFAS_uc002gks.2_Missense_Mutation_p.A50S	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	971					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TTACCGGGATGCTGGCCTCCA	0.662													20	44					8.10497e-08	8.88932e-08	1	0	T	8170160	T	T	8170160	3	4	31	1	0	0	0	0	1	0	0	0	11809	1319	46	4	2997	4	PFAS	17	8170160	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08		8170160	73025050	77	6127											
BCAS3	54828	broad.mit.edu	37	chr17	58824568	58824568	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcttatgcagatcagtggtGaagcacaagagctcttctct	10	12	9	10	0	4	3	1	1	3	2	5	3	4	3	0	1	3	3	0	1	3	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:58824568G>A	uc002iyv.3	+	6	440	c.331G>A	c.(331-333)GAA>AAA	p.E111K	BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Missense_Mutation_p.E111K|BCAS3_uc002iyw.3_Missense_Mutation_p.E107K	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	111	WD 1.					nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			GATCAGTGGTGAAGCACAAGA	0.378													53	106					0	0	0	0	A	58824568	A	A	58824568	3	1	31	1	0	0	0	0	1	0	0	0	1354	1291	45	2	349	2	BCAS3	17	58824568	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	50654408	58824568	22370642	78	6128											
LGALS3BP	3959	broad.mit.edu	37	chr17	76969075	76969076	+	Frame_Shift_Del	DEL	CA	-	-																															agaaggtccctgaccatgggCacacactcagcatccacact																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:76969075_76969076delCA	uc002jwh.2	-	5	784_785	c.605_606delTG	c.(604-606)GTGfs	p.V202fs	LGALS3BP_uc002jwi.2_Frame_Shift_Del_p.V8fs|LGALS3BP_uc010dhr.2_Frame_Shift_Del_p.V8fs	NM_005567	NP_005558	Q08380	LG3BP_HUMAN	galectin 3 binding protein	202	BTB.				cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			central_nervous_system(3)|ovary(1)	4			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			TGACCATGGGCACACACTCAGC	0.624													---	---	---								-	76969076	-	-	76969075	7	5	31	1	0	1	0	1	0	0	0	0	8784	697	25	0	1159	0	LGALS3BP	17	76969075	Frame_Shift_Del	DEL	CA	TCGA-BB-7864-01A-11D-2229-08	18144507	76969075	4226135	79	6129											
CCDC57	284001	broad.mit.edu	37	chr17	80173535	80173535	+	5'Flank	DEL	C	-	-																															cccctccccttccttccctgCcccccacactgcagcacccc																								rs112012232		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr17:80173535delC	uc002kdz.1	-						CCDC57_uc002kdx.1_5'Flank	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57											ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			tccttccctgccccccacact	0.313													---	---	---								-	80173535	-	-	80173535	6	5	31	0	1	1	0	1	0	0	0	0	2840	754	26	0		0	CCDC57	17	80173535	5'Flank	DEL	C	TCGA-BB-7864-01A-11D-2229-08	3204460	80173535	1021675	80	6130											
CDH19	28513	broad.mit.edu	37	chr18	64212132	64212132	+	Frame_Shift_Del	DEL	G	-	-																															agattcagagacagtcaagcGgtataaacctttaaaaacaa																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr18:64212132delG	uc002lkc.1	-	6	922	c.784delC	c.(784-786)CGCfs	p.R262fs	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Frame_Shift_Del_p.R262fs|CDH19_uc002lkd.2_Frame_Shift_Del_p.R262fs	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	262	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				ACAGTCAAGCGGTATAAACCT	0.294													---	---	---								-	64212132	-	-	64212132	7	5	31	1	0	1	0	1	0	0	0	0	3119	1116	39	0	1562	0	CDH19	18	64212132	Frame_Shift_Del	DEL	G	TCGA-BB-7864-01A-11D-2229-08		64212132	13865116	81	6131											
ZNF556	80032	broad.mit.edu	37	chr19	2877759	2877759	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagcactgtgggaaagcctTcaggtgtcagaaatcctttc	11	10	10	10	0	2	1	2	0	0	1	4	2	3	2	2	2	2	1	2	2	3	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:2877759T>G	uc002lwp.1	+	4	890	c.803T>G	c.(802-804)TTC>TGC	p.F268C	ZNF556_uc002lwq.2_Missense_Mutation_p.F267C	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	268	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGAAAGCCTTCAGGTGTCAG	0.542													8	37					0	0	0	0	G	2877759	G	G	2877759	3	3	31	1	0	0	0	0	1	0	0	0	18054	1783	62	5	817	5	ZNF556	19	2877759	Missense_Mutation	SNP	T	TCGA-BB-7864-01A-11D-2229-08		2877759	56251224	82	6132											
PTPRS	5802	broad.mit.edu	37	chr19	5274277	5274277	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgtggcttggggtcacccGtggcctgacacacgaaagag	8	7	14	12	3	1	2	1	1	0	1	2	3	1	2	2	4	0	1	2	4	1	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:5274277G>A	uc002mbv.2	-	3	404	c.170C>T	c.(169-171)ACG>ATG	p.T57M	PTPRS_uc002mbu.1_Missense_Mutation_p.T57M|PTPRS_uc010xin.1_Missense_Mutation_p.T57M|PTPRS_uc002mbw.2_Missense_Mutation_p.T57M|PTPRS_uc002mbx.2_Missense_Mutation_p.T57M|PTPRS_uc002mby.2_Missense_Mutation_p.T57M|PTPRS_uc002mbz.1_Missense_Mutation_p.T57M	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	57	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGGGTCACCCGTGGCCTGACA	0.597													9	34					0	0	0	0	A	5274277	A	A	5274277	3	1	31	1	0	0	0	0	1	0	0	0	12876	1145	40	1	5820	1	PTPRS	19	5274277	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	2396518	5274277	53854706	83	6133											
ZNF799	90576	broad.mit.edu	37	chr19	12501842	12501842	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaaggaatagaaatcaataAaggctttcccacatttgcat	17	10	7	7	0	1	1	1	0	0	1	2	3	2	2	1	2	1	2	1	2	7	4	rs78572821		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:12501842A>T	uc010dyt.2	-	4	1520	c.1370T>A	c.(1369-1371)TTT>TAT	p.F457Y	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	457	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						GAAATCAATAAAGGCTTTCCC	0.388													24	42					0	0	0	0	T	12501842	T	T	12501842	3	4	31	1	0	0	0	0	1	0	0	0	18233	14	1	5	565	5	ZNF799	19	12501842	Missense_Mutation	SNP	A	TCGA-BB-7864-01A-11D-2229-08	7227565	12501842	46627141	84	6134											
MYO9B	4650	broad.mit.edu	37	chr19	17283727	17283727	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccgggccatggcagtgcttCgggaggccggacgcctgcgg	4	6	18	13	5	0	0	0	0	0	0	2	2	1	2	4	6	2	2	4	6	0	1			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:17283727C>T	uc010eak.2	+	13	2247	c.2095C>T	c.(2095-2097)CGG>TGG	p.R699W	MYO9B_uc002nfi.2_Missense_Mutation_p.R699W|MYO9B_uc002nfj.1_Missense_Mutation_p.R699W	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	699	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GGCAGTGCTTCGGGAGGCCGG	0.687													29	57					0	0	0	0	T	17283727	T	T	17283727	3	4	31	1	0	0	0	0	1	0	0	0	10138	875	31	1	2141	1	MYO9B	19	17283727	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	4781885	17283727	41845256	85	6135											
MYO9B	4650	broad.mit.edu	37	chr19	17322568	17322568	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggaggagcgggccgggCggggggcctcggaaggtcag	5	4	23	9	4	1	0	1	0	0	0	2	3	1	3	2	9	2	1	2	9	1	0			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:17322568C>T	uc010eak.2	+	39	6195	c.6043C>T	c.(6043-6045)CGG>TGG	p.R2015W	MYO9B_uc002nfi.2_Missense_Mutation_p.R2015W|MYO9B_uc002nfm.1_Missense_Mutation_p.R175W	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	2015	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GCGGGCCGGGCGGGGGGCCTC	0.697													16	37					0	0	0	0	T	17322568	T	T	17322568	3	4	31	1	0	0	0	0	1	0	0	0	10138	759	27	1	6193	1	MYO9B	19	17322568	Missense_Mutation	SNP	C	TCGA-BB-7864-01A-11D-2229-08	38841	17322568	41806415	86	6136											
DYRK1B	9149	broad.mit.edu	37	chr19	40319075	40319075	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggccagaaagagcagtgcCgtgcagagctgctgcgccag	9	5	16	11	2	0	3	0	0	0	3	0	3	0	3	3	1	6	4	3	1	1	0			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:40319075C>A	uc002omj.2	-	6	949	c.669G>T	c.(667-669)ACG>ACT	p.T223T	DYRK1B_uc002omi.2_Silent_p.T223T|DYRK1B_uc002omk.2_Silent_p.T223T	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	223	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			AGAGCAGTGCCGTGCAGAGCT	0.602													6	13					0.000157383	0.000162152	1	0	A	40319075	A	A	40319075	2	1	31	1	0	0	0	0	0	0	0	1	4877	639	23	3		3	DYRK1B	19	40319075	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08	22996507	40319075	18809908	87	6137											
RCN3	57333	broad.mit.edu	37	chr19	50040344	50040344	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacaaaaagatgctggctcGggacgagcggcgtttccggg	9	7	15	10	5	0	1	0	0	0	1	2	3	1	2	1	4	3	3	1	4	3	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:50040344G>T	uc002poj.2	+	4	947	c.500G>T	c.(499-501)CGG>CTG	p.R167L		NM_020650	NP_065701	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	167	EF-hand 3.					endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		ATGCTGGCTCGGGACGAGCGG	0.572													69	142					1.37693e-34	1.63311e-34	1	0	T	50040344	T	T	50040344	3	4	31	1	0	0	0	0	1	0	0	0	13246	1116	39	3	510	3	RCN3	19	50040344	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08	9721269	50040344	9088639	88	6138											
KLK10	5655	broad.mit.edu	37	chr19	51518155	51518155	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacaggggtaaacaccccaCgagaggatgccttggagggt	11	5	14	11	1	0	1	0	0	0	1	0	4	0	3	4	5	2	1	4	5	2	2	rs138296032		TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:51518155C>G	uc002puy.2	-	6	813	c.732G>C	c.(730-732)TCG>TCC	p.S244S	KLK10_uc002puz.2_Silent_p.S244S|KLK10_uc002pva.2_Silent_p.S244S	NM_145888	NP_665895	O43240	KLK10_HUMAN	kallikrein-related peptidase 10 preproprotein	244	Peptidase S1.				cell cycle|proteolysis	extracellular region	serine-type endopeptidase activity			lung(2)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		AAACACCCCACGAGAGGATGC	0.537													12	52					0	0	0	0	G	51518155	G	G	51518155	2	3	31	1	0	0	0	0	0	0	0	1	8437	523	19	3		3	KLK10	19	51518155	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08	1477811	51518155	7610828	89	6139											
ZIM3	114026	broad.mit.edu	37	chr19	57647237	57647237	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaatttggatggattattGccaactaattttctgtatcc	12	16	6	7	0	1	0	0	0	1	0	2	2	2	2	2	2	2	1	2	2	5	7			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr19:57647237G>A	uc002qnz.1	-	5	854	c.468C>T	c.(466-468)GGC>GGT	p.G156G		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATGGATTATTGCCAACTAATT	0.368													58	120					0	0	0	0	A	57647237	A	A	57647237	2	1	31	1	0	0	0	0	0	0	0	1	17752	1306	46	4		4	ZIM3	19	57647237	Silent	SNP	G	TCGA-BB-7864-01A-11D-2229-08	6129082	57647237	1481746	90	6140											
RIN2	54453	broad.mit.edu	37	chr20	19981297	19981297	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcaggaggtcaacagtggttGcacaggaaagaccctccttg	11	8	12	10	0	2	1	2	0	0	1	3	3	3	3	2	4	2	2	2	4	2	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr20:19981297G>A	uc002wro.1	+	11	2441	c.2405G>A	c.(2404-2406)TGC>TAC	p.C802Y	RIN2_uc010gcu.1_Missense_Mutation_p.C369Y|RIN2_uc010gcv.1_Missense_Mutation_p.C596Y	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	802	Ras-associating.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						AACAGTGGTTGCACAGGAAAG	0.493													47	151					0	0	0	0	A	19981297	A	A	19981297	3	1	31	1	0	0	0	0	1	0	0	0	13437	1319	46	4	2447	4	RIN2	20	19981297	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08		19981297	43044223	91	6141											
CHRNA4	1137	broad.mit.edu	37	chr20	61982208	61982208	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaggtcgatcttggccttGtcgtaggtccaggagccgaa	8	9	13	11	3	1	0	0	0	1	0	4	3	2	1	4	4	1	1	4	4	2	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chr20:61982208G>A	uc002yes.2	-	5	733	c.555C>T	c.(553-555)GAC>GAT	p.D185D	CHRNA4_uc002yet.1_Silent_p.D9D|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.D114D|CHRNA4_uc002yev.1_Silent_p.D9D|CHRNA4_uc010gkf.1_Silent_p.D9D	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	185	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TCTTGGCCTTGTCGTAGGTCC	0.592													27	134					0	0	0	0	A	61982208	A	A	61982208	2	1	31	1	0	0	0	0	0	0	0	1	3400	1368	48	4		4	CHRNA4	20	61982208	Silent	SNP	G	TCGA-BB-7864-01A-11D-2229-08	42000911	61982208	1043312	92	6142											
ZCCHC5	203430	broad.mit.edu	37	chrX	77913339	77913339	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcctgggcatttgaaggCtccagaggctcctggggagg	8	9	15	9	0	0	2	0	1	0	1	3	3	3	3	3	6	0	3	3	6	2	2			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrX:77913339C>T	uc004edc.1	-	2	875	c.579G>A	c.(577-579)GAG>GAA	p.E193E		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	193	Pro-rich.						nucleic acid binding|zinc ion binding			ovary(1)	1						CATTTGAAGGCTCCAGAGGCT	0.537													4	8					0	0	0	0	T	77913339	T	T	77913339	2	4	31	1	0	0	0	0	0	0	0	1	17658	796	28	4		4	ZCCHC5	23	77913339	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08		77913339	77357221	93	6143											
SEPT6	23157	broad.mit.edu	37	chrX	118797474	118797474	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttgatctggtccccaaaGccaactgtgctaacgatcgt	9	12	9	11	2	1	1	0	1	1	0	3	2	2	1	3	1	4	2	3	1	3	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrX:118797474G>A	uc004erv.2	-	3	577	c.312C>T	c.(310-312)GGC>GGT	p.G104G	SEPT6_uc010nqk.2_RNA|SEPT6_uc004ers.2_Silent_p.G104G|SEPT6_uc004ert.2_Silent_p.G104G|SEPT6_uc004eru.2_Silent_p.G104G|SEPT6_uc004erw.2_Silent_p.G46G|SEPT6_uc011mtv.1_Silent_p.G46G|SEPT6_uc011mtw.1_Silent_p.G134G	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	104		GTP; via amide nitrogen (By similarity).			cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4						GGTCCCCAAAGCCAACTGTGC	0.572													145	116					0	0	0	0	A	118797474	A	A	118797474	2	1	31	1	0	0	0	0	0	0	0	1	14133	958	34	4		4	SEPT6	23	118797474	Silent	SNP	G	TCGA-BB-7864-01A-11D-2229-08	40884135	118797474	36473086	94	6144											
CT47B1	643311	broad.mit.edu	37	chrX	120009066	120009066	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcacagcagcgtggggcccCaccatcaggcggctgaggtg	7	4	17	13	2	1	1	1	1	0	0	1	1	1	1	3	6	2	3	3	6	0	0			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrX:120009066C>T	uc011muc.1	-	1	714	c.459G>A	c.(457-459)GTG>GTA	p.V153V		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	153											0						CGTGGGGCCCCACCATCAGGC	0.652													10	39					0	0	0	0	T	120009066	T	T	120009066	2	4	31	1	0	0	0	0	0	0	0	1	4006	581	21	4		4	CT47B1	23	120009066	Silent	SNP	C	TCGA-BB-7864-01A-11D-2229-08	1211592	120009066	35261494	95	6145											
AFF2	2334	broad.mit.edu	37	chrX	148038070	148038070	+	Frame_Shift_Del	DEL	C	-	-																															gccagaccacaaggagactgCcacaaaacccaagcgtcaga																										TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrX:148038070delC	uc004fcp.2	+	11	2974	c.2495delC	c.(2494-2496)GCCfs	p.A832fs	AFF2_uc004fcq.2_Frame_Shift_Del_p.A822fs|AFF2_uc004fcr.2_Frame_Shift_Del_p.A793fs|AFF2_uc011mxb.1_Frame_Shift_Del_p.A797fs|AFF2_uc004fcs.2_Frame_Shift_Del_p.A799fs|AFF2_uc011mxc.1_Frame_Shift_Del_p.A473fs	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	832					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGAGACTGCCACAAAACCC	0.527													---	---	---								-	148038070	-	-	148038070	7	5	31	1	0	1	0	1	0	0	0	0	357	739	26	0	2592	0	AFF2	23	148038070	Frame_Shift_Del	DEL	C	TCGA-BB-7864-01A-11D-2229-08	28029004	148038070	7232490	96	6146											
PCDH11Y	83259	broad.mit.edu	37	chrY	4968515	4968515	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcaagcctgacagccctGatttggcccgacactacaaa	11	9	7	14	1	1	2	1	2	0	0	1	3	1	2	3	1	3	0	3	1	3	3			TCGA-BB-7864-01A-11D-2229-08	TCGA-BB-7864-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d6324a3-8bb4-45d1-89b3-134ffca01aec	db5989e5-7e20-4c78-b78e-15cb47af9ee3	g.chrY:4968515G>T	uc004fqo.2	+	2	3630	c.2896G>T	c.(2896-2898)GAT>TAT	p.D966Y	PCDH11Y_uc010nwg.1_Missense_Mutation_p.D955Y|PCDH11Y_uc004fql.1_Missense_Mutation_p.D955Y|PCDH11Y_uc004fqm.1_Missense_Mutation_p.D955Y|PCDH11Y_uc004fqn.1_Missense_Mutation_p.D966Y|PCDH11Y_uc004fqp.1_Missense_Mutation_p.D737Y	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	966	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TGACAGCCCTGATTTGGCCCG	0.463													106	24					2.24849e-53	2.69819e-53	1	0	T	4968515	T	T	4968515	3	4	31	1	0	0	0	0	1	0	0	0	11563	1290	45	2	2938	2	PCDH11Y	24	4968515	Missense_Mutation	SNP	G	TCGA-BB-7864-01A-11D-2229-08		4968515	54405051	97	6147											
PER3	8863	broad.mit.edu	37	chr1	7863187	7863187	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgcaccctgaagatcgttCtctgatggttgccatacacc	8	11	8	14	1	1	3	0	2	1	1	3	3	1	3	4	1	3	3	4	1	2	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr1:7863187C>G	uc001aoo.2	+	8	1125	c.950C>G	c.(949-951)TCT>TGT	p.S317C	PER3_uc009vmg.1_Missense_Mutation_p.S318C|PER3_uc009vmh.1_Missense_Mutation_p.S318C|PER3_uc001aop.2_Missense_Mutation_p.S318C|PER3_uc010nzw.1_5'UTR|PER3_uc001aon.2_Missense_Mutation_p.S317C	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	317	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGATCGTTCTCTGATGGTT	0.423													44	59					0	0	0	0	G	7863187	G	G	7863187	3	3	32	1	0	0	0	0	1	0	0	0	11785	913	32	2	980	2	PER3	1	7863187	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08		7863187	241387434	1	6148											
COL16A1	1307	broad.mit.edu	37	chr1	32154073	32154073	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taacccaggtctcaccttctCtcctttcagccctggaaccc	7	11	5	18	0	3	0	2	0	2	0	6	1	4	1	5	2	3	0	5	2	2	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr1:32154073C>T	uc001btk.1	-	26	2163	c.1798G>A	c.(1798-1800)GAG>AAG	p.E600K	COL16A1_uc001btj.1_Missense_Mutation_p.E429K|COL16A1_uc001btl.3_Missense_Mutation_p.E600K	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	600	Triple-helical region 7 (COL7) with 1 imperfection.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CTCACCTTCTCTCCTTTCAGC	0.567													41	107					0	0	0	0	T	32154073	T	T	32154073	3	4	32	1	0	0	0	0	1	0	0	0	3688	922	32	2	3200	2	COL16A1	1	32154073	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	24290886	32154073	217096548	2	6149											
ROR1	4919	broad.mit.edu	37	chr1	64643424	64643424	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgagttcctcatcatgaGatccccacactctgatgttg	9	12	7	13	0	3	3	2	3	1	1	5	4	5	3	4	0	0	2	4	0	0	2			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr1:64643424G>T	uc001dbj.2	+	9	2099	c.1700G>T	c.(1699-1701)AGA>ATA	p.R567I	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	567	Cytoplasmic (Potential).|Protein kinase.		R -> I (in a colorectal adenocarcinoma sample; somatic mutation).		transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding	p.R567I(1)		ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						CTCATCATGAGATCCCCACAC	0.468													28	49					2.79863e-10	3.00341e-10	1	0	T	64643424	T	T	64643424	3	4	32	1	0	0	0	0	1	0	0	0	13591	942	33	2	1742	2	ROR1	1	64643424	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	32489351	64643424	184607197	3	6150											
CD2	914	broad.mit.edu	37	chr1	117297336	117297336	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttggacattcctagttttCaaatgagtgatgatattgac	12	15	8	6	0	1	4	1	4	0	0	2	5	2	5	1	1	0	1	1	1	3	7			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr1:117297336C>T	uc001egu.3	+	2	174	c.145C>T	c.(145-147)CAA>TAA	p.Q49*	CD2_uc010owz.1_Nonsense_Mutation_p.Q49*|CD2_uc010oxa.1_Nonsense_Mutation_p.Q49*	NM_001767	NP_001758	P06729	CD2_HUMAN	CD2 molecule precursor	49	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			breast(1)	1	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	TCCTAGTTTTCAAATGAGTGA	0.373													32	43					0	0	0	0	T	117297336	T	T	117297336	4	4	32	1	0	0	0	0	0	1	0	0	2994	827	29	2	151	2	CD2	1	117297336	Nonsense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	52653912	117297336	131953285	4	6151											
RFX5	5993	broad.mit.edu	37	chr1	151315612	151315612	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttcttccgctctccacgtgCgagaggaccggccccagttc	5	9	10	17	4	2	1	0	0	2	1	5	3	3	2	5	2	1	2	5	2	0	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr1:151315612C>T	uc001exv.1	-	11	1115	c.901G>A	c.(901-903)GCA>ACA	p.A301T	RFX5_uc001exw.1_Missense_Mutation_p.A301T|RFX5_uc009wmr.1_Missense_Mutation_p.A301T|RFX5_uc010pcx.1_Missense_Mutation_p.A261T	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	301						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCTCCACGTGCGAGAGGACCG	0.542													26	74					0	0	0	0	T	151315612	T	T	151315612	3	4	32	1	0	0	0	0	1	0	0	0	13331	768	27	1	953	1	RFX5	1	151315612	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	34018276	151315612	97935009	5	6152											
S100A7A	338324	broad.mit.edu	37	chr1	153390616	153390617	+	Frame_Shift_Ins	INS	-	A	A																															gatcgacatgtttcacaaatINSacaccggacgtgatggcaag																								rs138663810	byFrequency	TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr1:153390616_153390617insA	uc001fbt.1	+	2	115_116	c.58_59insA	c.(58-60)TACfs	p.Y20fs		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	20	EF-hand 1.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTTTCACAAATACACCGGACGT	0.45													---	---	---								A	153390617	A	A	153390616	7	5	32	1	0	1	1	0	0	0	0	0	13849	1406	49	0	60	0	S100A7A	1	153390616	Frame_Shift_Ins	INS	-	TCGA-BB-7866-01A-11D-2229-08	2075004	153390616	95860005	6	6153											
FCRL5	83416	broad.mit.edu	37	chr1	157509156	157509157	+	Splice_Site	INS	-	GA	GA																															caggatgagacacgggaactINSgagagagagaaaaaattagt																										TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr1:157509156_157509157insGA	uc001fqu.2	-	7	1282	c.1124_splice	c.e7-1	p.V375_splice	FCRL5_uc009wsm.2_Splice_Site_p.V375_splice|FCRL5_uc010phv.1_Splice_Site_p.V375_splice|FCRL5_uc010phw.1_Splice_Site_p.V290_splice|FCRL5_uc001fqv.1_Splice_Site_p.V375_splice|FCRL5_uc010phx.1_Splice_Site_p.V126_splice	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5							integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				ACACGGGAACTGAGAGAGAGAA	0.366													---	---	---								GA	157509157	GA	GA	157509156	8	5	32	1	0	1	1	0	0	0	1	0	5830	1594	55	0	1855	0	FCRL5	1	157509156	Splice_Site	INS	-	TCGA-BB-7866-01A-11D-2229-08	4118540	157509156	91741465	7	6154											
LOC642587	642587	broad.mit.edu	37	chr1	209605573	209605574	+	Frame_Shift_Ins	INS	-	GC	GC																															agtggagtgaagttcaggagINSgcatggagctgacaaccatg																										TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr1:209605573_209605574insGC	uc009xcn.2	+	4	571_572	c.188_189insGC	c.(187-189)AGGfs	p.R63fs	LOC642587_uc010psk.1_RNA|MIR205_hsa-mir-205|MI0000285_RNA	NM_001104548	NP_001098018			hypothetical protein LOC642587												0				OV - Ovarian serous cystadenocarcinoma(81;0.0422)		AAGTTCAGGAGGCATGGAGCTG	0.292													---	---	---								GC	209605574	GC	GC	209605573	7	5	32	1	0	1	1	0	0	0	0	0	8931	1000	35	0	198	0	LOC642587	1	209605573	Frame_Shift_Ins	INS	-	TCGA-BB-7866-01A-11D-2229-08	52096417	209605573	39645048	8	6155											
DISC1	27185	broad.mit.edu	37	chr1	231830149	231830149	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctttagctttattcggctCtcgcttggctctgccgggga	4	14	12	11	3	2	0	0	0	2	0	4	1	2	1	1	4	3	5	1	4	2	6			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr1:231830149C>T	uc001huz.2	+	2	698	c.645C>T	c.(643-645)CTC>CTT	p.L215L	TSNAX-DISC1_uc010pwe.1_Silent_p.L170L|TSNAX-DISC1_uc010pwf.1_Silent_p.L170L|TSNAX-DISC1_uc010pwg.1_Silent_p.L204L|TSNAX-DISC1_uc010pwh.1_Silent_p.L170L|TSNAX-DISC1_uc010pwi.1_Silent_p.L170L|TSNAX-DISC1_uc010pwj.1_Silent_p.L204L|TSNAX-DISC1_uc010pwk.1_Silent_p.L204L|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwo.1_Silent_p.L215L|DISC1_uc010pwp.1_Silent_p.L215L|DISC1_uc010pwq.1_Silent_p.L215L|DISC1_uc010pwr.1_Silent_p.L215L|DISC1_uc010pws.1_Silent_p.L215L|DISC1_uc010pwt.1_Silent_p.L215L|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Silent_p.L215L|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Silent_p.L215L|DISC1_uc010pxb.1_Silent_p.L215L|DISC1_uc010pxc.1_Silent_p.L215L|DISC1_uc010pxd.1_5'UTR|DISC1_uc010pxe.1_Silent_p.L215L|DISC1_uc009xfr.2_Silent_p.L170L|DISC1_uc010pxf.1_Silent_p.L215L|DISC1_uc010pxg.1_Silent_p.L215L|DISC1_uc010pxh.1_Silent_p.L215L|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_5'UTR|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Silent_p.L215L|DISC1_uc010pxn.1_5'UTR|DISC1_uc001hva.2_Silent_p.L215L|DISC1_uc010pwm.1_Silent_p.L215L|DISC1_uc001hux.1_Silent_p.L215L|DISC1_uc001hvc.3_Silent_p.L215L|DISC1_uc010pwn.1_Silent_p.L215L	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	215	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				TTATTCGGCTCTCGCTTGGCT	0.607													20	43					0	0	0	0	T	231830149	T	T	231830149	2	4	32	1	0	0	0	0	0	0	0	1	4560	900	32	2		2	DISC1	1	231830149	Silent	SNP	C	TCGA-BB-7866-01A-11D-2229-08	22224576	231830149	17420472	9	6156											
ZNF513	130557	broad.mit.edu	37	chr2	27600843	27600843	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtttcaggttatccagatGagcagaggcataaggacagc	12	8	12	9	1	1	3	1	1	0	2	2	4	2	4	2	3	2	4	2	3	2	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr2:27600843G>A	uc002rkk.2	-	4	1395	c.1195C>T	c.(1195-1197)CAT>TAT	p.H399Y	ZNF513_uc002rkj.2_Missense_Mutation_p.H337Y	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	399	C2H2-type 5.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTATCCAGATGAGCAGAGGCA	0.587													56	160					0	0	0	0	A	27600843	A	A	27600843	3	1	32	1	0	0	0	0	1	0	0	0	18025	1290	45	2	434	2	ZNF513	2	27600843	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08		27600843	215598530	10	6157											
DNAH7	56171	broad.mit.edu	37	chr2	196636519	196636519	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tacctcctcatggcagcctcGatgtcgaagttgtttggaag	8	12	11	10	2	1	0	1	0	0	0	4	3	2	1	3	2	2	3	3	2	3	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr2:196636519G>C	uc002utj.3	-	61	11399	c.11298C>G	c.(11296-11298)ATC>ATG	p.I3766M	DNAH7_uc002uti.3_Missense_Mutation_p.I249M	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3766					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGGCAGCCTCGATGTCGAAGT	0.453													54	148					0	0	0	0	C	196636519	C	C	196636519	3	2	32	1	0	0	0	0	1	0	0	0	4628	1048	37	3	796	3	DNAH7	2	196636519	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	169035676	196636519	46562854	11	6158											
GTF3C3	9330	broad.mit.edu	37	chr2	197637642	197637642	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaataactgggaaatcacctGatatagttgtatgcctttct	13	14	7	7	0	2	1	1	1	1	0	2	2	2	2	2	1	2	2	2	1	6	6			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr2:197637642G>A	uc002uts.2	-	14	2157	c.2067C>T	c.(2065-2067)ATC>ATT	p.I689I	GTF3C3_uc010zgu.1_Silent_p.I660I	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	689						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						GAAATCACCTGATATAGTTGT	0.323													10	22					0	0	0	0	A	197637642	A	A	197637642	2	1	32	1	0	0	0	0	0	0	0	1	6913	1280	45	2		2	GTF3C3	2	197637642	Silent	SNP	G	TCGA-BB-7866-01A-11D-2229-08	1001123	197637642	45561731	12	6159											
CELSR3	1951	broad.mit.edu	37	chr3	48669776	48669776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggagtcgttcaaggcctgcgGggccagggattctgtcacac	7	8	15	11	2	3	0	2	0	1	0	4	2	3	2	2	5	1	1	2	5	1	2	rs140373134	by1000genomes	TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr3:48669776G>A	uc003cuf.1	-	41	10702	c.10702C>T	c.(10702-10704)CCG>TCG	p.P3568S	SLC26A6_uc003cug.2_Missense_Mutation_p.P142S|SLC26A6_uc003cuh.2_Missense_Mutation_p.P163S|SLC26A6_uc010hke.2_Missense_Mutation_p.P14S|SLC26A6_uc003cuk.2_Intron|SLC26A6_uc003cui.2_Missense_Mutation_p.P163S|SLC26A6_uc003cuj.2_Missense_Mutation_p.P163S|SLC26A6_uc011bbp.1_Intron	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AAGGCCTGCGGGGCCAGGGAT	0.597													8	30					0	0	0	0	A	48669776	A	A	48669776	3	1	32	1	0	0	0	0	1	0	0	0	3238	1232	43	4		4	CELSR3	3	48669776	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08		48669776	149352654	13	6160											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			12	24					0	0	0	0	A	178936091	A	A	178936091	3	1	32	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	130266315	178936091	19086339	14	6161											
DLG1	1739	broad.mit.edu	37	chr3	197009663	197009663	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttcagacggctttgaacGatctatacattttggattat	10	16	9	6	2	2	2	1	1	1	1	2	4	2	3	0	3	2	2	0	3	4	7			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr3:197009663G>T	uc003fxo.3	-	4	395	c.205C>A	c.(205-207)CGT>AGT	p.R69S	DLG1_uc011bud.1_5'UTR|DLG1_uc003fxn.3_Missense_Mutation_p.R69S|DLG1_uc011bue.1_Missense_Mutation_p.R69S|DLG1_uc010ial.2_Missense_Mutation_p.R69S|DLG1_uc011buf.1_RNA|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Missense_Mutation_p.R69S	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	69					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GGCTTTGAACGATCTATACAT	0.358													46	103					5.57489e-27	6.05667e-27	1	0	T	197009663	T	T	197009663	3	4	32	1	0	0	0	0	1	0	0	0	4576	1058	37	3	2705	3	DLG1	3	197009663	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	18073572	197009663	1012767	15	6162											
MMRN1	22915	broad.mit.edu	37	chr4	90844391	90844393	+	In_Frame_Del	DEL	AGC	-	-																															tgttggcagaggagtagctgAgcagcagcagcagcaaggct																										TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr4:90844391_90844393delAGC	uc003hst.2	+	4	994_996	c.923_925delAGC	c.(922-927)GAGCAG>GAG	p.Q313del	MMRN1_uc010iku.2_In_Frame_Del_p.Q279del|MMRN1_uc011cds.1_In_Frame_Del_p.Q55del	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	313	Poly-Gln.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		GGAGTAGCTGAGCAGCAGCAGCA	0.448													---	---	---								-	90844393	-	-	90844391	7	5	32	1	0	1	0	1	0	0	0	0	9723	304	11	0	937	0	MMRN1	4	90844391	In_Frame_Del	DEL	AGC	TCGA-BB-7866-01A-11D-2229-08		90844391	100309885	16	6163											
PCDHGB1	56104	broad.mit.edu	37	chr5	140731511	140731511	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccacgggtgctgtaccccGcgctggggcctgatggctcc	3	7	15	16	4	0	1	0	1	0	0	1	1	1	1	5	4	2	4	5	4	1	1			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr5:140731511G>A	uc003ljo.1	+	1	1684	c.1684G>A	c.(1684-1686)GCG>ACG	p.A562T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.A562T	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	562	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGTACCCCGCGCTGGGGCC	0.697													29	60					0	0	0	0	A	140731511	A	A	140731511	3	1	32	1	0	0	0	0	1	0	0	0	11616	1087	38	1	1686	1	PCDHGB1	5	140731511	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08		140731511	40183749	17	6164											
BTN2A2	10385	broad.mit.edu	37	chr6	26392980	26392980	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggcgtcttcctggactatGaagctggagatgtctccttc	6	13	12	10	1	2	2	0	1	2	1	5	4	3	3	2	3	1	1	2	3	2	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr6:26392980G>A	uc003nhq.2	+	8	1443	c.1357G>A	c.(1357-1359)GAA>AAA	p.E453K	BTN2A2_uc011dkg.1_3'UTR|BTN2A2_uc003nhr.2_Missense_Mutation_p.E337K|BTN2A2_uc011dkh.1_Missense_Mutation_p.E243K|BTN2A2_uc003nhs.2_Intron|BTN2A2_uc003nht.2_Missense_Mutation_p.E453K|BTN2A2_uc011dki.1_3'UTR	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	453	B30.2/SPRY.|Cytoplasmic (Potential).				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						CCTGGACTATGAAGCTGGAGA	0.542													17	43					0	0	0	0	A	26392980	A	A	26392980	3	1	32	1	0	0	0	0	1	0	0	0	1566	1291	45	2	1383	2	BTN2A2	6	26392980	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08		26392980	144722087	18	6165											
FOXO3	2309	broad.mit.edu	37	chr6	108882906	108882906	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctgtcctacgcggacctGatcacccgcgccatcgagag	9	6	10	16	5	1	2	1	1	0	1	3	4	2	3	5	1	2	0	5	1	2	1	rs149906214		TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr6:108882906G>A	uc003psk.2	+	2	811	c.495G>A	c.(493-495)CTG>CTA	p.L165L	FOXO3_uc003psn.2_Silent_p.L165L|FOXO3_uc003psm.2_Silent_p.L165L	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	165	Fork-head.				antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		ACGCGGACCTGATCACCCGCG	0.672													6	18					0	0	0	0	A	108882906	A	A	108882906	2	1	32	1	0	0	0	0	0	0	0	1	6058	1277	45	2		2	FOXO3	6	108882906	Silent	SNP	G	TCGA-BB-7866-01A-11D-2229-08	82489926	108882906	62232161	19	6166											
EYA4	2070	broad.mit.edu	37	chr6	133802648	133802648	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacacccatcaaagatcttGatgagagaacctgtaggagt	14	8	9	10	0	2	4	1	2	1	2	2	6	2	5	3	1	1	1	3	1	3	2			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr6:133802648G>A	uc003qec.3	+	12	1476	c.1018G>A	c.(1018-1020)GAT>AAT	p.D340N	EYA4_uc011ecq.1_Missense_Mutation_p.D286N|EYA4_uc011ecr.1_Missense_Mutation_p.D292N|EYA4_uc003qed.3_Missense_Mutation_p.D340N|EYA4_uc003qee.3_Missense_Mutation_p.D317N|EYA4_uc011ecs.1_Missense_Mutation_p.D346N|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	340					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CAAAGATCTTGATGAGAGAAC	0.458													46	111					0	0	0	0	A	133802648	A	A	133802648	3	1	32	1	0	0	0	0	1	0	0	0	5356	1290	45	2	1060	2	EYA4	6	133802648	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	24919742	133802648	37312419	20	6167											
GPR146	115330	broad.mit.edu	37	chr7	1097172	1097172	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtggagctgcagctggttCaacggcacagggctggtgga	8	8	17	8	1	1	0	1	0	0	0	1	2	1	2	0	6	4	6	0	6	1	1			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr7:1097172C>G	uc003sjw.2	+	2	97	c.21C>G	c.(19-21)TTC>TTG	p.F7L	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPR146_uc003sjx.3_Missense_Mutation_p.F7L|GPR146_uc003sjy.1_Missense_Mutation_p.F7L	NM_138445	NP_612454	Q96CH1	GP146_HUMAN	G protein-coupled receptor 146	7	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GCAGCTGGTTCAACGGCACAG	0.687													10	17					0	0	0	0	G	1097172	G	G	1097172	3	3	32	1	0	0	0	0	1	0	0	0	6690	825	29	2	23	2	GPR146	7	1097172	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08		1097172	158041491	21	6168											
NOS3	4846	broad.mit.edu	37	chr7	150706129	150706129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accggctgagcgcccaggccGagggcctgcagttgctgcca	6	5	15	15	3	0	1	0	1	0	0	0	2	0	1	5	3	4	4	5	3	0	1			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr7:150706129G>A	uc003wif.2	+	18	2520	c.2224G>A	c.(2224-2226)GAG>AAG	p.E742K	NOS3_uc011kuy.1_Missense_Mutation_p.E536K	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	742					anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CGCCCAGGCCGAGGGCCTGCA	0.682											OREG0018442	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	13					0	0	0	0	A	150706129	A	A	150706129	3	1	32	1	0	0	0	0	1	0	0	0	10598	1059	37	1	2572	1	NOS3	7	150706129	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	149608957	150706129	8432534	22	6169											
RP1	6101	broad.mit.edu	37	chr8	55537326	55537326	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctacttagactattcttttgTtcctgaaaagtacttggcct	9	17	6	9	0	1	2	0	1	1	1	2	2	2	2	2	1	2	2	2	1	6	9			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr8:55537326T>C	uc003xsd.1	+	4	1032	c.884T>C	c.(883-885)GTT>GCT	p.V295A	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	295					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATTCTTTTGTTCCTGAAAAG	0.308													18	26					0	0	0	0	C	55537326	C	C	55537326	3	2	32	1	0	0	0	0	1	0	0	0	13597	1725	60	5	894	5	RP1	8	55537326	Missense_Mutation	SNP	T	TCGA-BB-7866-01A-11D-2229-08		55537326	90826696	23	6170											
FAM135B	51059	broad.mit.edu	37	chr8	139164197	139164197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gatgtctatgtatccggggcCctgctggttgtcagcatcta	6	13	12	10	1	3	0	1	0	2	0	4	1	4	0	2	3	2	4	2	3	3	4			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr8:139164197C>T	uc003yuy.2	-	13	2692	c.2521G>A	c.(2521-2523)GGC>AGC	p.G841S	FAM135B_uc003yux.2_Missense_Mutation_p.G742S|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.G403S|FAM135B_uc003yvb.2_Missense_Mutation_p.G403S	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	841										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TATCCGGGGCCCTGCTGGTTG	0.517										HNSCC(54;0.14)			17	48					0	0	0	0	T	139164197	T	T	139164197	3	4	32	1	0	0	0	0	1	0	0	0	5477	623	22	4	1731	4	FAM135B	8	139164197	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	83626871	139164197	7199825	24	6171											
RANBP6	26953	broad.mit.edu	37	chr9	6015424	6015424	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtctcacctcataacctgCtcttctatttctgacggcat	7	16	5	13	1	5	1	2	1	4	0	6	1	5	1	2	1	2	2	2	1	2	5			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr9:6015424C>T	uc003zjr.2	-	1	195	c.184G>A	c.(184-186)GCA>ACA	p.A62T	RANBP6_uc011lmf.1_Missense_Mutation_p.A62T|RANBP6_uc003zjs.2_Intron	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	62					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TCATAACCTGCTCTTCTATTT	0.483													35	70					0	0	0	0	T	6015424	T	T	6015424	3	4	32	1	0	0	0	0	1	0	0	0	13096	797	28	4	3137	4	RANBP6	9	6015424	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08		6015424	135198007	25	6172											
MCART1	92014	broad.mit.edu	37	chr9	37887677	37887677	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tataacctttaacaagaactCataagttgcattgattatgc	15	14	5	7	0	1	2	1	1	0	1	1	2	1	2	1	0	5	2	1	0	7	8			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr9:37887677C>G	uc004aau.2	-	3	1615	c.871G>C	c.(871-873)GAG>CAG	p.E291Q	MCART1_uc004aar.1_Intron|MCART1_uc004aaq.1_Intron|uc004aat.1_5'Flank|MCART1_uc004aav.2_Missense_Mutation_p.E291Q	NM_033412	NP_219480	Q9H1U9	MCAR1_HUMAN	mitochondrial carrier triple repeat 1	291	Solcar 3.				transport	integral to membrane|mitochondrial inner membrane				ovary(2)|breast(1)	3				GBM - Glioblastoma multiforme(29;0.00559)|Lung(182;0.0422)		AACAAGAACTCATAAGTTGCA	0.383													20	52					0	0	0	0	G	37887677	G	G	37887677	3	3	32	1	0	0	0	0	1	0	0	0	9422	835	29	2	26	2	MCART1	9	37887677	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	31872253	37887677	103325754	26	6173											
NANS	54187	broad.mit.edu	37	chr9	100819144	100819144	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtgggcgggcaacacccGtgcttcatcattgccgagat	7	9	14	11	3	2	1	2	0	0	1	2	2	2	1	2	3	3	2	2	3	1	2			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr9:100819144G>T	uc004ayb.2	+	2	696	c.54G>T	c.(52-54)CCG>CCT	p.P18P	NANS_uc004ayc.2_Silent_p.P18P	NM_018946	NP_061819	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid phosphate synthase	18					lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GGCAACACCCGTGCTTCATCA	0.647													9	32					0.000673444	0.000681185	1	0	T	100819144	T	T	100819144	2	4	32	1	0	0	0	0	0	0	0	1	10208	1132	40	3		3	NANS	9	100819144	Silent	SNP	G	TCGA-BB-7866-01A-11D-2229-08	62931467	100819144	40394287	27	6174											
PPP2R4	5524	broad.mit.edu	37	chr9	131873256	131873256	+	5'Flank	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtggaggaggaaggaggAggtcaccgtccagctgtctc	8	7	16	10	1	2	0	1	0	1	0	4	5	3	5	3	6	1	1	3	6	1	0	rs3118625	by1000genomes	TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr9:131873256A>C	uc004bxm.1	+						CRAT_uc004bxg.2_5'Flank|CRAT_uc004bxk.3_5'Flank|CRAT_uc004bxh.2_5'Flank|CRAT_uc004bxj.2_5'Flank|PPP2R4_uc004bxl.1_5'UTR|PPP2R4_uc011mbo.1_5'Flank|PPP2R4_uc010myr.1_5'Flank|PPP2R4_uc004bxn.1_5'Flank|PPP2R4_uc004bxo.1_5'Flank|PPP2R4_uc011mbp.1_5'Flank|PPP2R4_uc011mbq.1_5'Flank|PPP2R4_uc010mys.1_5'Flank	NM_178001	NP_821068	Q15257	PTPA_HUMAN	protein phosphatase 2A, regulatory subunit B'						ATP catabolic process|negative regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|positive regulation of apoptosis|positive regulation of phosphoprotein phosphatase activity|positive regulation of protein dephosphorylation	calcium channel complex|cytoplasm|nucleus|protein phosphatase type 2A complex|soluble fraction	ATP binding|peptidyl-prolyl cis-trans isomerase activity|protein heterodimerization activity|protein homodimerization activity|protein phosphatase 2A binding|protein phosphatase type 2A regulator activity|protein tyrosine phosphatase activator activity|receptor binding			ovary(1)|lung(1)|pancreas(1)	3		Medulloblastoma(224;0.235)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)		AGGAAGGAGGAGGTCACCGTC	0.642											OREG0003932	type=REGULATORY REGION|Gene=CRAT|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	15	67					0	0	0	0	C	131873256	C	C	131873256	1	2	32	0	1	0	0	0	0	0	0	0	12451	319	11	5		5	PPP2R4	9	131873256	5'Flank	SNP	A	TCGA-BB-7866-01A-11D-2229-08	31054112	131873256	9340175	28	6175											
KIAA1462	57608	broad.mit.edu	37	chr10	30317108	30317108	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcatttgtttgtctgtcttCttctggttcccctagatctt	3	21	7	10	0	6	1	1	0	5	1	7	1	7	1	2	1	0	2	2	1	1	7			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr10:30317108C>T	uc001iux.2	-	2	2028	c.1969G>A	c.(1969-1971)GAA>AAA	p.E657K	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.E519K|KIAA1462_uc009xle.1_Missense_Mutation_p.E657K	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	657										ovary(4)	4						TGTCTGTCTTCTTCTGGTTCC	0.517													15	25					0	0	0	0	T	30317108	T	T	30317108	3	4	32	1	0	0	0	0	1	0	0	0	8273	922	32	2	2118	2	KIAA1462	10	30317108	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08		30317108	105217639	29	6176											
ZEB1	6935	broad.mit.edu	37	chr10	31809260	31809260	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagatacggcaaaagataGagaataaaccccttcaagaa	20	5	7	9	1	1	4	1	0	0	4	1	5	1	4	2	1	2	1	2	1	9	4			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr10:31809260G>C	uc001ivs.3	+	7	1060	c.997G>C	c.(997-999)GAG>CAG	p.E333Q	ZEB1_uc001ivr.3_Missense_Mutation_p.E115Q|ZEB1_uc010qee.1_Missense_Mutation_p.E115Q|ZEB1_uc010qef.1_Missense_Mutation_p.E115Q|ZEB1_uc009xlj.1_Missense_Mutation_p.E259Q|ZEB1_uc010qeg.1_Missense_Mutation_p.E192Q|ZEB1_uc009xlk.1_Missense_Mutation_p.E115Q|ZEB1_uc001ivt.3_Missense_Mutation_p.E115Q|ZEB1_uc001ivu.3_Missense_Mutation_p.E334Q|ZEB1_uc001ivv.3_Missense_Mutation_p.E313Q|ZEB1_uc010qeh.1_Missense_Mutation_p.E266Q|ZEB1_uc009xlo.1_Missense_Mutation_p.E316Q|ZEB1_uc009xlp.2_Missense_Mutation_p.E317Q	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	333					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				GCAAAAGATAGAGAATAAACC	0.438													15	26					0	0	0	0	C	31809260	C	C	31809260	3	2	32	1	0	0	0	0	1	0	0	0	17690	943	33	2	1037	2	ZEB1	10	31809260	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	1492152	31809260	103725487	30	6177											
PLAC9	219348	broad.mit.edu	37	chr10	81904065	81904065	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggcctggaacctgcccccGggacccttcagccccgctcc	4	6	10	21	2	1	0	1	0	0	0	2	2	2	2	8	3	3	1	8	3	1	1			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr10:81904065G>A	uc001kbp.1	+	3	510	c.249G>A	c.(247-249)CCG>CCA	p.P83P		NM_001012973	NP_001012991	Q5JTB6	PLAC9_HUMAN	placenta-specific 9 precursor	83						extracellular region					0	Prostate(51;0.0095)|all_epithelial(25;0.175)		Colorectal(32;0.109)			ACCTGCCCCCGGGACCCTTCA	0.657											OREG0020321	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	14					0	0	0	0	A	81904065	A	A	81904065	2	1	32	1	0	0	0	0	0	0	0	1	12072	1103	39	1		1	PLAC9	10	81904065	Silent	SNP	G	TCGA-BB-7866-01A-11D-2229-08	50094805	81904065	53630682	31	6178											
C11orf35	256329	broad.mit.edu	37	chr11	558714	558714	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcctggatctccagttctcGctgtctccacagcagccgca	6	9	10	16	2	3	0	0	0	3	0	6	1	3	1	4	2	2	4	4	2	0	1			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr11:558714G>A	uc001lpx.2	-	3	274	c.211C>T	c.(211-213)CGA>TGA	p.R71*	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank|RASSF7_uc001lqb.2_5'Flank|RASSF7_uc001lqc.2_5'Flank|RASSF7_uc001lqd.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	71										pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCCAGTTCTCGCTGTCTCCAC	0.667													4	10					0	0	0	0	A	558714	A	A	558714	4	1	32	1	0	0	0	0	0	1	0	0	1644	1095	38	1	1741	1	C11orf35	11	558714	Nonsense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08		558714	134447802	32	6179											
OR52B6	340980	broad.mit.edu	37	chr11	5602330	5602330	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcctctcccaggcaatccTgcatgagcccatgtacatat	10	10	6	15	0	1	1	0	1	1	0	4	1	3	1	4	1	3	3	4	1	3	2			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr11:5602330T>A	uc010qzi.1	+	1	224	c.224T>A	c.(223-225)CTG>CAG	p.L75Q	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGCAATCCTGCATGAGCCC	0.502													21	76					0	0	0	0	A	5602330	A	A	5602330	3	1	32	1	0	0	0	0	1	0	0	0	11167	1580	55	5	226	5	OR52B6	11	5602330	Missense_Mutation	SNP	T	TCGA-BB-7866-01A-11D-2229-08	5043616	5602330	129404186	33	6180											
HPX	3263	broad.mit.edu	37	chr11	6461935	6461935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctggcttggtctcgccttCagcaacattcccatgggcac	6	11	10	14	1	3	0	1	0	2	0	5	0	4	0	2	3	2	3	2	3	1	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr11:6461935C>T	uc001mdg.2	-	2	170	c.109G>A	c.(109-111)GAA>AAA	p.E37K	HPX_uc001mdf.2_5'Flank|HPX_uc009yfc.2_RNA|HPX_uc010rai.1_Missense_Mutation_p.E37K	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	37	O-glycosylated at one, two and three sites.				cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		GTCTCGCCTTCAGCAACATTC	0.502													33	82					0	0	0	0	T	6461935	T	T	6461935	3	4	32	1	0	0	0	0	1	0	0	0	7385	835	29	2	1315	2	HPX	11	6461935	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	859605	6461935	128544581	34	6181											
B3GAT3	26229	broad.mit.edu	37	chr11	62384595	62384595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagtccagggccttgttcCgctgctcgacaccacgggga	6	7	13	15	3	0	0	0	0	0	0	3	2	2	1	5	3	1	3	5	3	0	2			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr11:62384595C>T	uc001ntw.2	-	3	511	c.482G>A	c.(481-483)CGG>CAG	p.R161Q	B3GAT3_uc009ynz.2_Missense_Mutation_p.R154Q|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Missense_Mutation_p.R161Q	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	161	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						GGCCTTGTTCCGCTGCTCGAC	0.662													20	68					0	0	0	0	T	62384595	T	T	62384595	3	4	32	1	0	0	0	0	1	0	0	0	1257	652	23	1	537	1	B3GAT3	11	62384595	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	55922660	62384595	72621921	35	6182											
LOH12CR1	118426	broad.mit.edu	37	chr12	12618499	12618500	+	Frame_Shift_Del	DEL	CT	-	-																															gatggatctgtctgtagaaaCtctgttcagcttcatgcagg																										TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr12:12618499_12618500delCT	uc001ral.2	+	4	746_747	c.380_381delCT	c.(379-381)ACTfs	p.T127fs	LOH12CR1_uc009zhu.2_Frame_Shift_Del_p.T79fs	NM_058169	NP_477517	Q969J3	L12R1_HUMAN	LOH1CR12	127										ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.0205)		TCTGTAGAAACTCTGTTCAGCT	0.515													---	---	---								-	12618500	-	-	12618499	7	5	32	1	0	1	0	1	0	0	0	0	8941	565	20	0	394	0	LOH12CR1	12	12618499	Frame_Shift_Del	DEL	CT	TCGA-BB-7866-01A-11D-2229-08		12618499	121233396	36	6183											
PLEKHA5	54477	broad.mit.edu	37	chr12	19498823	19498823	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagttaagtacaaaaatgagGtaagtttggattgtttttct	13	16	9	3	0	1	1	0	1	1	0	1	2	1	2	0	2	1	5	0	2	5	7			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr12:19498823G>A	uc001reb.2	+	18	2486	c.2400_splice	c.e18+1	p.E800_splice	PLEKHA5_uc010sie.1_Splice_Site_p.E898_splice|PLEKHA5_uc001rea.2_Splice_Site_p.E858_splice|PLEKHA5_uc009zin.2_Splice_Site_p.E558_splice|PLEKHA5_uc010sif.1_Splice_Site_p.E726_splice|PLEKHA5_uc010sig.1_Splice_Site_p.E719_splice|PLEKHA5_uc010sih.1_Splice_Site_p.E692_splice|PLEKHA5_uc001rec.1_Splice_Site_p.E546_splice|PLEKHA5_uc009zio.2_Intron	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A								1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					CAAAAATGAGGTAAGTTTGGA	0.234													6	23					0	0	0	0	A	19498823	A	A	19498823	5	1	32	1	0	0	0	0	0	0	1	0	12114	1275	44	4	2596	4	PLEKHA5	12	19498823	Splice_Site	SNP	G	TCGA-BB-7866-01A-11D-2229-08	6880324	19498823	114353072	37	6184											
MLL2	8085	broad.mit.edu	37	chr12	49444054	49444054	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccagggctggggcagggctgGgggcggggcaggaaaggtcc	6	3	23	9	1	0	0	0	0	0	0	1	1	1	1	2	10	0	4	2	10	1	0			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr12:49444054G>A	uc001rta.3	-	11	3317	c.3317C>T	c.(3316-3318)CCC>CTC	p.P1106L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1106	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCAGGGCTGGGGGCGGGGCA	0.612			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			12	22					0	0	0	0	A	49444054	A	A	49444054	3	1	32	1	0	0	0	0	1	0	0	0	9674	1232	43	4	13472	4	MLL2	12	49444054	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	29945231	49444054	84407841	38	6185											
C12orf51	283450	broad.mit.edu	37	chr12	112688011	112688011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctgagctttatcatgattCctggaggcagtctgatccga	8	12	10	11	1	2	3	1	3	1	0	4	5	4	4	3	2	1	2	3	2	1	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr12:112688011C>T	uc009zwc.2	-	18	2639	c.2621G>A	c.(2620-2622)GGA>GAA	p.G874E	C12orf51_uc010syk.1_Missense_Mutation_p.G696E|C12orf51_uc001tts.2_Missense_Mutation_p.G687E|C12orf51_uc001ttt.3_Missense_Mutation_p.G685E	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TATCATGATTCCTGGAGGCAG	0.458													9	30					0	0	0	0	T	112688011	T	T	112688011	3	4	32	1	0	0	0	0	1	0	0	0	1702	855	30	2	9577	2	C12orf51	12	112688011	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	63243957	112688011	21163884	39	6186											
C13orf34	79866	broad.mit.edu	37	chr13	73320857	73320857	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaaggtgaagatgaggaaGataaagagaatattccttcc	16	9	10	6	0	1	5	1	2	0	3	3	7	3	6	2	2	0	0	2	2	7	4			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr13:73320857G>C	uc001viv.1	+	10	1209	c.1090G>C	c.(1090-1092)GAT>CAT	p.D364H	C13orf34_uc010thq.1_Missense_Mutation_p.D139H|C13orf34_uc010aen.1_Missense_Mutation_p.D439H|C13orf34_uc010thr.1_Missense_Mutation_p.D294H|C13orf34_uc001viw.1_Missense_Mutation_p.D313H	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	364					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		AGATGAGGAAGATAAAGAGAA	0.448													44	101					0	0	0	0	C	73320857	C	C	73320857	3	2	32	1	0	0	0	0	1	0	0	0	1734	942	33	2	1124	2	C13orf34	13	73320857	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08		73320857	41849021	40	6187											
C13orf34	79866	broad.mit.edu	37	chr13	73321010	73321010	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaatcagtccagtgcttctGagaaagaattagcactgttg	14	11	9	7	0	2	2	1	1	1	2	3	3	3	2	1	0	2	3	1	0	5	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr13:73321010G>A	uc001viv.1	+	10	1362	c.1243G>A	c.(1243-1245)GAG>AAG	p.E415K	C13orf34_uc010thq.1_Missense_Mutation_p.E190K|C13orf34_uc010aen.1_Missense_Mutation_p.E490K|C13orf34_uc010thr.1_Missense_Mutation_p.E345K|C13orf34_uc001viw.1_Missense_Mutation_p.E364K	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	415					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		CAGTGCTTCTGAGAAAGAATT	0.423													18	59					0	0	0	0	A	73321010	A	A	73321010	3	1	32	1	0	0	0	0	1	0	0	0	1734	1291	45	2	1277	2	C13orf34	13	73321010	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	153	73321010	41848868	41	6188											
NALCN	259232	broad.mit.edu	37	chr13	101742207	101742207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcgcttaccggccccacaCgatgaataataacatctctc	11	9	6	15	3	1	1	0	1	1	0	4	2	1	1	3	1	2	2	3	1	4	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr13:101742207C>T	uc001vox.1	-	29	3569	c.3380G>A	c.(3379-3381)CGT>CAT	p.R1127H		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1127	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CGGCCCCACACGATGAATAAT	0.423													88	197					0	0	0	0	T	101742207	T	T	101742207	3	4	32	1	0	0	0	0	1	0	0	0	10201	536	19	1	1900	1	NALCN	13	101742207	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	28421197	101742207	13427671	42	6189											
OR4K13	390433	broad.mit.edu	37	chr14	20502654	20502654	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caccatgagatggtcttacgTtctcggaggaaatctacaat	12	11	9	9	2	3	1	0	1	3	1	4	4	3	3	1	3	2	1	1	3	4	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr14:20502654T>C	uc010tkz.1	-	1	264	c.264A>G	c.(262-264)GAA>GAG	p.E88E		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TGGTCTTACGTTCTCGGAGGA	0.448													11	34					0	0	0	0	C	20502654	C	C	20502654	2	2	32	1	0	0	0	0	0	0	0	1	11122	1722	60	5		5	OR4K13	14	20502654	Silent	SNP	T	TCGA-BB-7866-01A-11D-2229-08		20502654	86846886	43	6190											
MYH7	4625	broad.mit.edu	37	chr14	23900628	23900628	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagattcatggcactcacaGgtctctatgtctgcagatgc	9	11	10	11	0	4	2	2	0	2	2	5	2	4	2	0	2	2	3	0	2	1	2			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr14:23900628G>T	uc001wjx.2	-	9	901	c.795C>A	c.(793-795)ACC>ACA	p.T265T		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	265	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GGCACTCACAGGTCTCTATGT	0.413													47	138					1.64573e-32	1.81031e-32	1	0	T	23900628	T	T	23900628	2	4	32	1	0	0	0	0	0	0	0	1	10092	1014	35	4		4	MYH7	14	23900628	Silent	SNP	G	TCGA-BB-7866-01A-11D-2229-08	3397974	23900628	83448912	44	6191											
RPS6KA5	9252	broad.mit.edu	37	chr14	91372495	91372495	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctattcaataatttcacctGaaagaagagatgttctttga	14	15	6	6	0	4	4	2	2	2	2	4	5	4	4	1	0	0	1	1	0	5	6			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr14:91372495G>A	uc001xys.2	-	8	1170	c.955C>T	c.(955-957)CAG>TAG	p.Q319*	RPS6KA5_uc010twi.1_Nonsense_Mutation_p.Q240*|RPS6KA5_uc001xyt.2_Nonsense_Mutation_p.Q319*|RPS6KA5_uc010att.1_RNA	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	319	AGC-kinase C-terminal.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		AATTTCACCTGAAAGAAGAGA	0.413													24	48					0	0	0	0	A	91372495	A	A	91372495	4	1	32	1	0	0	0	0	0	1	0	0	13719	1299	45	2	1499	2	RPS6KA5	14	91372495	Nonsense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	67471867	91372495	15977045	45	6192											
KIAA0284	283638	broad.mit.edu	37	chr14	105349504	105349504	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaggagaccccgcagccgtCgcagccccccgaggtgccgg	7	2	15	17	5	0	1	0	0	0	1	1	4	0	1	7	3	3	2	7	3	1	0			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr14:105349504C>T	uc010axb.2	+	8	934	c.710C>T	c.(709-711)TCG>TTG	p.S237L	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.S167L|KIAA0284_uc001yps.2_Missense_Mutation_p.S143L	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	237						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		CCGCAGCCGTCGCAGCCCCCC	0.711													4	16					0	0	0	0	T	105349504	T	T	105349504	3	4	32	1	0	0	0	0	1	0	0	0	8205	893	31	1	736	1	KIAA0284	14	105349504	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	13977009	105349504	2000036	46	6193											
AHNAK2	113146	broad.mit.edu	37	chr14	105415731	105415731	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggggagactcacgtcggcCtccaccttgggtgcaggcac	7	6	15	13	2	1	1	1	0	0	1	3	3	2	1	3	5	1	2	3	5	0	1	rs139340205	by1000genomes	TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr14:105415731C>T	uc010axc.1	-	7	6177	c.6057G>A	c.(6055-6057)GAG>GAA	p.E2019E	AHNAK2_uc001ypx.2_Silent_p.E1919E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2019						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCACGTCGGCCTCCACCTTGG	0.617													22	59					0	0	0	0	T	105415731	T	T	105415731	2	4	32	1	0	0	0	0	0	0	0	1	415	680	24	4		4	AHNAK2	14	105415731	Silent	SNP	C	TCGA-BB-7866-01A-11D-2229-08	66227	105415731	1933809	47	6194											
ATP10A	57194	broad.mit.edu	37	chr15	25972326	25972326	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgcgtagatgacaatgccGacgactgcgtccgtgttcct	7	10	11	13	5	0	2	0	1	0	1	2	4	2	2	4	0	3	2	4	0	2	2			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr15:25972326G>A	uc010ayu.2	-	4	934	c.828C>T	c.(826-828)GTC>GTT	p.V276V		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	276	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TGACAATGCCGACGACTGCGT	0.552													22	24					0	0	0	0	A	25972326	A	A	25972326	2	1	32	1	0	0	0	0	0	0	0	1	1118	1045	37	1		1	ATP10A	15	25972326	Silent	SNP	G	TCGA-BB-7866-01A-11D-2229-08		25972326	76559066	48	6195											
ITPKA	3706	broad.mit.edu	37	chr15	41793928	41793928	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctgatggctgacgcgctgCgcggctgcgtgcctgccttc	2	9	16	14	5	0	2	0	2	0	0	1	2	0	2	2	3	4	4	2	3	0	1			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr15:41793928C>T	uc001znz.2	+	3	693	c.682C>T	c.(682-684)CGC>TGC	p.R228C		NM_002220	NP_002211	P23677	IP3KA_HUMAN	1D-myo-inositol-trisphosphate 3-kinase A	228					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		TGACGCGCTGCGCGGCTGCGT	0.682													6	21					0	0	0	0	T	41793928	T	T	41793928	3	4	32	1	0	0	0	0	1	0	0	0	7956	768	27	1	692	1	ITPKA	15	41793928	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	15821602	41793928	60737464	49	6196											
SGSM2	9905	broad.mit.edu	37	chr17	2275526	2275526	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagagtatgaagaggcagatCgtgtcccgggccttctacgg	9	8	15	9	3	1	4	0	1	1	3	3	5	2	4	2	3	1	2	2	3	3	3			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr17:2275526C>T	uc002fun.3	+	13	1660	c.1485C>T	c.(1483-1485)ATC>ATT	p.I495I	SGSM2_uc002fum.3_Silent_p.I540I|SGSM2_uc010vqw.1_Silent_p.I495I|SGSM2_uc002fuo.2_Silent_p.I83I	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	495						intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		AGAGGCAGATCGTGTCCCGGG	0.706													14	60					0	0	0	0	T	2275526	T	T	2275526	2	4	32	1	0	0	0	0	0	0	0	1	14288	874	31	1		1	SGSM2	17	2275526	Silent	SNP	C	TCGA-BB-7866-01A-11D-2229-08		2275526	78919684	50	6197											
SGSM2	9905	broad.mit.edu	37	chr17	2276633	2276633	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgagtacaggtggacgcAgtggtggcagcaaggtacca	10	7	16	8	1	1	1	0	1	1	0	1	2	1	2	1	5	3	5	1	5	3	2			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr17:2276633A>G	uc002fun.3	+	16	1966	c.1791A>G	c.(1789-1791)GCA>GCG	p.A597A	SGSM2_uc002fum.3_Silent_p.A642A|SGSM2_uc010vqw.1_Silent_p.A597A|SGSM2_uc002fuo.2_3'UTR|SGSM2_uc002fup.1_5'Flank	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	597	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		AGGTGGACGCAGTGGTGGCAG	0.662													12	56					0	0	0	0	G	2276633	G	G	2276633	2	3	32	1	0	0	0	0	0	0	0	1	14288	175	7	5		5	SGSM2	17	2276633	Silent	SNP	A	TCGA-BB-7866-01A-11D-2229-08	1107	2276633	78918577	51	6198											
MRM1	79922	broad.mit.edu	37	chr17	34964135	34964135	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagggctggctcgtggcCggcacggtgggctgcccaag	5	5	18	13	3	0	0	0	0	0	0	1	0	0	0	2	6	2	5	2	6	1	0	rs113915340		TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr17:34964135C>T	uc002hne.2	+	3	881	c.666C>T	c.(664-666)GCC>GCT	p.A222A	MRM1_uc002hnf.2_Silent_p.A27A	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	222					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GGCTCGTGGCCGGCACGGTGG	0.463													72	164					0	0	0	0	T	34964135	T	T	34964135	2	4	32	1	0	0	0	0	0	0	0	1	9824	639	23	1		1	MRM1	17	34964135	Silent	SNP	C	TCGA-BB-7866-01A-11D-2229-08	32687502	34964135	46231075	52	6199											
STAT3	6774	broad.mit.edu	37	chr17	40474419	40474419	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaccaggatattggtagcaTccatgatcttatagcccatg	12	11	8	10	0	1	1	0	1	1	0	2	2	2	2	3	2	2	2	3	2	4	5			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr17:40474419T>A	uc002hzl.1	-	21	2222	c.1982A>T	c.(1981-1983)GAT>GTT	p.D661V	STAT3_uc002hzk.1_Missense_Mutation_p.D661V|STAT3_uc002hzm.1_Missense_Mutation_p.D661V|STAT3_uc010wgh.1_Missense_Mutation_p.D563V|STAT3_uc002hzn.1_Missense_Mutation_p.D661V	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	661	SH2.				cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		ATTGGTAGCATCCATGATCTT	0.483									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				61	143					0	0	0	0	A	40474419	A	A	40474419	3	1	32	1	0	0	0	0	1	0	0	0	15332	1435	50	5	346	5	STAT3	17	40474419	Missense_Mutation	SNP	T	TCGA-BB-7866-01A-11D-2229-08	5510284	40474419	40720791	53	6200											
FOXK2	3607	broad.mit.edu	37	chr17	80540627	80540627	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttcatagaattcaattcGccacaatctctctctgaatc	11	15	4	11	1	4	2	2	1	2	1	8	2	4	2	1	0	0	1	1	0	5	4			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr17:80540627G>A	uc002kfn.2	+	5	1091	c.920G>A	c.(919-921)CGC>CAC	p.R307H	FOXK2_uc002kfm.1_Missense_Mutation_p.R307H|FOXK2_uc010diu.2_Intron	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	307	DNA-binding; major groove.|Fork-head.			R->A: Abolishes DNA-binding.	embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			AATTCAATTCGCCACAATCTC	0.393													9	26					0	0	0	0	A	80540627	A	A	80540627	3	1	32	1	0	0	0	0	1	0	0	0	6049	1087	38	1	938	1	FOXK2	17	80540627	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	40066208	80540627	654583	54	6201											
CCDC11	220136	broad.mit.edu	37	chr18	47753897	47753897	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaactctcggcgtttctcttCcttctctgcttcttgggact	4	17	7	13	2	4	0	0	0	4	0	8	1	5	1	1	2	2	2	1	2	1	5			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr18:47753897C>T	uc002lee.2	-	8	1490	c.1399G>A	c.(1399-1401)GAA>AAA	p.E467K		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	467	Potential.									ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		CGTTTCTCTTCCTTCTCTGCT	0.488													35	87					0	0	0	0	T	47753897	T	T	47753897	3	4	32	1	0	0	0	0	1	0	0	0	2758	864	30	2	149	2	CCDC11	18	47753897	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08		47753897	30323351	55	6202											
CLEC4M	10332	broad.mit.edu	37	chr19	7830969	7830969	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagtgggtgagttgccagaGaaatccaagctgcaggagat	12	7	15	7	0	0	3	0	1	0	2	1	5	1	3	2	2	3	4	2	2	2	1			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr19:7830969G>C	uc002mih.2	+	5	709	c.591G>C	c.(589-591)GAG>GAC	p.E197D	CLEC4M_uc010xjv.1_Missense_Mutation_p.E192D|CLEC4M_uc002mhy.2_Missense_Mutation_p.E164D|CLEC4M_uc010xjw.1_Intron|CLEC4M_uc010dvt.2_Missense_Mutation_p.E174D|CLEC4M_uc010dvs.2_Missense_Mutation_p.E196D|CLEC4M_uc010xjx.1_Missense_Mutation_p.E169D|CLEC4M_uc002mhz.2_Intron|CLEC4M_uc002mic.2_Missense_Mutation_p.E192D|CLEC4M_uc002mia.2_Intron	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	220	Extracellular (Probable).|5.|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						AGTTGCCAGAGAAATCCAAGC	0.557													27	116					0	0	0	0	C	7830969	C	C	7830969	3	2	32	1	0	0	0	0	1	0	0	0	3533	933	33	2	695	2	CLEC4M	19	7830969	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08		7830969	51298014	56	6203											
MUC16	94025	broad.mit.edu	37	chr19	9090538	9090538	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aagttccttctgtttcctttCcactcgtggagtgatgggtg	5	16	11	9	1	1	1	0	1	1	0	5	2	4	2	3	2	0	2	3	2	1	4			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr19:9090538C>A	uc002mkp.2	-	1	1481	c.1277G>T	c.(1276-1278)GGA>GTA	p.G426V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	426	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTTTCCTTTCCACTCGTGGA	0.512													16	44					0.00316338	0.00316338	1	0	A	9090538	A	A	9090538	3	1	32	1	0	0	0	0	1	0	0	0	10026	855	30	2	42582	2	MUC16	19	9090538	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	1259569	9090538	50038445	57	6204											
ELL	8178	broad.mit.edu	37	chr19	18576334	18576334	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcgtcggtggcacacacCgtgatcttgtcctgtatgct	6	12	12	11	3	1	1	0	1	1	0	4	2	2	1	2	2	1	3	2	2	1	2			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr19:18576334C>T	uc002njh.2	-	4	429	c.357G>A	c.(355-357)ACG>ACA	p.T119T	ELL_uc010ebq.2_Silent_p.T62T|ELL_uc002njg.2_5'UTR	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	119					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)		TGGCACACACCGTGATCTTGT	0.622			T	MLL	AL								15	33					0	0	0	0	T	18576334	T	T	18576334	2	4	32	1	0	0	0	0	0	0	0	1	5086	639	23	1		1	ELL	19	18576334	Silent	SNP	C	TCGA-BB-7866-01A-11D-2229-08	9485796	18576334	40552649	58	6205											
ZNF208	7757	broad.mit.edu	37	chr19	22155677	22155677	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacattcttcacatttgtagGgtttctctccagtatgaatt	9	17	6	9	0	3	1	1	1	2	0	5	1	4	1	1	1	0	3	1	1	3	7			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr19:22155677G>C	uc002nqp.2	-	5	2008	c.1859C>G	c.(1858-1860)CCC>CGC	p.P620R	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATTTGTAGGGTTTCTCTCC	0.378													7	24					0	0	0	0	C	22155677	C	C	22155677	3	2	32	1	0	0	0	0	1	0	0	0	17833	1232	43	4	1687	4	ZNF208	19	22155677	Missense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08	3579343	22155677	36973306	59	6206											
ZNF492	57615	broad.mit.edu	37	chr19	22847039	22847039	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acctttctacacataaaagaAttcatactggaaagaaaccc	18	9	4	10	0	2	2	1	0	1	2	2	3	2	3	2	1	3	0	2	1	7	5			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr19:22847039A>C	uc002nqw.3	+	4	812	c.568A>C	c.(568-570)ATT>CTT	p.I190L		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	190	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				ACATAAAAGAATTCATACTGG	0.368													3	8					0	0	0	0	C	22847039	C	C	22847039	3	2	32	1	0	0	0	0	1	0	0	0	18010	101	4	5	578	5	ZNF492	19	22847039	Missense_Mutation	SNP	A	TCGA-BB-7866-01A-11D-2229-08	691362	22847039	36281944	60	6207											
ZNF540	163255	broad.mit.edu	37	chr19	38103616	38103616	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgggaagacctttcgagttCgttctcaaattagtctacat	10	14	9	8	2	2	1	1	0	2	1	5	3	2	2	1	1	1	2	1	1	4	5			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr19:38103616C>T	uc002ogq.2	+	5	1767	c.1435C>T	c.(1435-1437)CGT>TGT	p.R479C	ZNF540_uc002ogu.2_Missense_Mutation_p.R479C|ZNF540_uc010efq.2_Missense_Mutation_p.R447C	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	479	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTTTCGAGTTCGTTCTCAAAT	0.403													11	40					0	0	0	0	T	38103616	T	T	38103616	3	4	32	1	0	0	0	0	1	0	0	0	18042	884	31	1	1449	1	ZNF540	19	38103616	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	15256577	38103616	21025367	61	6208											
ZNF45	7596	broad.mit.edu	37	chr19	44426335	44426335	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caactcaccttagacttcgtCattttgtcctcctccttctg	6	16	4	15	1	3	1	2	0	1	1	7	1	6	1	4	0	1	0	4	0	2	5			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr19:44426335C>G	uc002oxu.1	-	1	102	c.3G>C	c.(1-3)ATG>ATC	p.M1I	ZNF45_uc002oxw.1_Missense_Mutation_p.M1I|ZNF45_uc002oxv.1_Missense_Mutation_p.M1I	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	1					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TAGACTTCGTCATTTTGTCCT	0.403													10	12					0	0	0	0	G	44426335	G	G	44426335	3	3	32	1	0	0	0	0	1	0	0	0	17988	826	29	2	2061	2	ZNF45	19	44426335	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	6322719	44426335	14702648	62	6209											
FUT1	2523	broad.mit.edu	37	chr19	49253657	49253658	+	Frame_Shift_Del	DEL	AA	-	-																															ttgcactgtgtgagcagggcAaagtctttccacggtgtagc																										TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr19:49253657_49253658delAA	uc002pkk.2	-	4	1856_1857	c.881_882delTT	c.(880-882)TTTfs	p.F294fs		NM_000148	NP_000139	P19526	FUT1_HUMAN	fucosyltransferase 1	294	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			ovary(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		TGAGCAGGGCAAAGTCTTTCCA	0.564													---	---	---								-	49253658	-	-	49253657	7	5	32	1	0	1	0	1	0	0	0	0	6135	127	5	0	219	0	FUT1	19	49253657	Frame_Shift_Del	DEL	AA	TCGA-BB-7866-01A-11D-2229-08	4827322	49253657	9875326	63	6210											
ZNF880	400713	broad.mit.edu	37	chr19	52887427	52887427	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctttagagtgtcttcaagActtgctaacaatcaagtaat	13	13	7	8	0	3	2	2	0	1	2	3	2	3	2	1	0	2	2	1	0	6	6	rs8104808	by1000genomes	TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr19:52887427A>C	uc002pzc.2	+	4	643	c.594A>C	c.(592-594)AGA>AGC	p.R198S		NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	198	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TGTCTTCAAGACTTGCTAACA	0.373													4	7					0	0	0	0	C	52887427	C	C	52887427	3	2	32	1	0	0	0	0	1	0	0	0	18264	272	10	5	608	5	ZNF880	19	52887427	Missense_Mutation	SNP	A	TCGA-BB-7866-01A-11D-2229-08	3633770	52887427	6241556	64	6211											
ZNF787	126208	broad.mit.edu	37	chr19	56599489	56599489	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccgcgcggtagtagctctgtCcgcagctgctgcagaccgag	6	7	14	14	5	1	1	0	0	1	1	2	2	2	1	3	1	4	7	3	1	2	2			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr19:56599489C>G	uc010eth.1	-	3	1171	c.1052G>C	c.(1051-1053)GGA>GCA	p.G351A		NM_001002836	NP_001002836	Q6DD87	ZN787_HUMAN	zinc finger protein 787	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0559)		GTAGCTCTGTCCGCAGCTGCT	0.741													10	21					0	0	0	0	G	56599489	G	G	56599489	3	3	32	1	0	0	0	0	1	0	0	0	18226	855	30	2	103	2	ZNF787	19	56599489	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	3712062	56599489	2529494	65	6212											
GTSE1	51512	broad.mit.edu	37	chr22	46725995	46725995	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgagccctgaggctgacaagGagaacgtggattccccactc	10	7	12	12	1	0	4	0	3	0	1	2	6	1	5	3	3	2	1	3	3	2	1			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chr22:46725995G>T	uc011aqy.1	+	12	2400	c.2188G>T	c.(2188-2190)GAG>TAG	p.E730*	GTSE1_uc011aqz.1_Nonsense_Mutation_p.E577*|GTSE1_uc003bhn.2_RNA|uc011ara.1_5'Flank|uc003bho.3_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	711					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		GGCTGACAAGGAGAACGTGGA	0.532													19	36					5.35267e-07	5.60756e-07	1	0	T	46725995	T	T	46725995	4	4	32	1	0	0	0	0	0	1	0	0	6924	1175	41	2	2230	2	GTSE1	22	46725995	Nonsense_Mutation	SNP	G	TCGA-BB-7866-01A-11D-2229-08		46725995	4578571	66	6213											
DCAF8L2	347442	broad.mit.edu	37	chrX	27766045	27766045	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaagatgctgttgtcttcAccattgacctcagacaagac	11	11	9	10	0	3	5	2	2	1	3	3	5	3	5	2	0	1	2	2	0	2	3	rs5926895	by1000genomes	TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chrX:27766045A>G	uc011mjy.1	+	1	1120	c.1033A>G	c.(1033-1035)ACC>GCC	p.T345A		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						TGTTGTCTTCACCATTGACCT	0.478													4	8					0	0	0	0	G	27766045	G	G	27766045	3	3	32	1	0	0	0	0	1	0	0	0	4295	159	6	5	1035	5	DCAF8L2	23	27766045	Missense_Mutation	SNP	A	TCGA-BB-7866-01A-11D-2229-08		27766045	127504515	67	6214											
SLC7A3	84889	broad.mit.edu	37	chrX	70145695	70145695	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatagagagtgccgggatCaaggtctacagttttggctc	10	10	13	8	1	2	1	1	0	1	1	3	4	2	2	1	3	2	2	1	3	3	4			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chrX:70145695C>A	uc004dyn.2	-	12	1986	c.1828G>T	c.(1828-1830)GAT>TAT	p.D610Y	SLC7A3_uc004dyo.2_Missense_Mutation_p.D610Y	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	610	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GTGCCGGGATCAAGGTCTACA	0.498													19	24					1.9806e-07	2.09991e-07	1	0	A	70145695	A	A	70145695	3	1	32	1	0	0	0	0	1	0	0	0	14762	826	29	2	35	2	SLC7A3	23	70145695	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08	42379650	70145695	85124865	68	6215											
PCDH11Y	83259	broad.mit.edu	37	chrY	4924992	4924992	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccgggacgtacattttcgCggtcctgctagtatgcgtgg	5	12	14	10	5	0	0	0	0	0	0	3	1	2	1	2	3	3	3	2	3	3	5			TCGA-BB-7866-01A-11D-2229-08	TCGA-BB-7866-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6ae619-b33e-453c-aa6d-dda14cd5a337	2a133813-bed7-462f-a34b-4462f5b40b81	g.chrY:4924992C>T	uc004fqo.2	+	1	862	c.128C>T	c.(127-129)GCG>GTG	p.A43V	PCDH11Y_uc010nwg.1_Missense_Mutation_p.A32V|PCDH11Y_uc004fql.1_Missense_Mutation_p.A32V|PCDH11Y_uc004fqm.1_Missense_Mutation_p.A32V|PCDH11Y_uc004fqn.1_Missense_Mutation_p.A43V	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	43	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TACATTTTCGCGGTCCTGCTA	0.473													9	8					0	0	0	0	T	4924992	T	T	4924992	3	4	32	1	0	0	0	0	1	0	0	0	11563	768	27	1	166	1	PCDH11Y	24	4924992	Missense_Mutation	SNP	C	TCGA-BB-7866-01A-11D-2229-08		4924992	54448574	69	6216											
CYP4A22	284541	broad.mit.edu	37	chr1	47606535	47606535	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttattggatatggggaggCaaagttcgtgtccagctcta	9	12	12	8	1	1	0	0	0	1	0	3	2	2	2	2	4	1	3	2	4	4	5			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr1:47606535C>G	uc001cqv.1	+	2	330	c.279C>G	c.(277-279)GGC>GGG	p.G93G	CYP4A22_uc009vyo.2_Silent_p.G93G|CYP4A22_uc009vyp.2_Silent_p.G93G	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	93						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						TATGGGGAGGCAAAGTTCGTG	0.507													17	32					0	0	0	0	G	47606535	G	G	47606535	2	3	33	1	0	0	0	0	0	0	0	1	4201	697	25	4		4	CYP4A22	1	47606535	Silent	SNP	C	TCGA-BB-7870-01A-11D-2229-08		47606535	201644086	1	6217											
BRDT	676	broad.mit.edu	37	chr1	92459709	92459709	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcagaccacaccttcacatGtaatgccaccaaatcaccac	15	7	3	16	0	3	1	3	0	0	1	3	1	3	1	5	0	1	1	5	0	2	2			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr1:92459709G>A	uc001dok.3	+	15	2534	c.2185G>A	c.(2185-2187)GTA>ATA	p.V729I	BRDT_uc001dol.3_Missense_Mutation_p.V729I|BRDT_uc010osz.1_Missense_Mutation_p.V733I|BRDT_uc009wdf.2_Missense_Mutation_p.V656I|BRDT_uc010ota.1_Missense_Mutation_p.V683I|BRDT_uc010otb.1_Missense_Mutation_p.V683I|BRDT_uc001dom.3_Missense_Mutation_p.V729I	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	729					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		ACCTTCACATGTAATGCCACC	0.363													13	30					0	0	0	0	A	92459709	A	A	92459709	3	1	33	1	0	0	0	0	1	0	0	0	1513	1377	48	4	2239	4	BRDT	1	92459709	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	44853174	92459709	156790912	2	6218											
RPAP2	79871	broad.mit.edu	37	chr1	92789439	92789439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgaaagtgaatacagtaGgtcagaaataactctagtag	16	11	9	5	0	3	3	1	2	2	1	3	3	3	3	0	1	2	2	0	1	8	6			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr1:92789439G>A	uc001dot.2	+	8	1071	c.962G>A	c.(961-963)AGG>AAG	p.R321K	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	321						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		GAATACAGTAGGTCAGAAATA	0.348													3	4					0	0	0	0	A	92789439	A	A	92789439	3	1	33	1	0	0	0	0	1	0	0	0	13607	1000	35	4	992	4	RPAP2	1	92789439	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	329730	92789439	156461182	3	6219											
SPAG17	200162	broad.mit.edu	37	chr1	118583438	118583438	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaccctgagatttgagtgggTatatttcccatattgtatcc	9	15	9	8	0	0	2	0	2	0	1	2	4	2	2	3	1	0	2	3	1	4	7			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr1:118583438T>A	uc001ehk.2	-	22	3149	c.3081A>T	c.(3079-3081)ATA>ATT	p.I1027I		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1027						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTTGAGTGGGTATATTTCCCA	0.368													10	17					0	0	0	0	A	118583438	A	A	118583438	2	1	33	1	0	0	0	0	0	0	0	1	15045	1628	57	5		5	SPAG17	1	118583438	Silent	SNP	T	TCGA-BB-7870-01A-11D-2229-08	25793999	118583438	130667183	4	6220											
NUP210L	91181	broad.mit.edu	37	chr1	153973462	153973462	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagttgaccactcttacagaGtaaatggccaggccaggagt	13	8	11	9	0	1	2	0	1	1	1	1	3	1	3	3	3	1	2	3	3	4	3			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr1:153973462G>A	uc001fdw.2	-	37	5328	c.5256C>T	c.(5254-5256)TAC>TAT	p.Y1752Y	NUP210L_uc009woq.2_Silent_p.Y661Y|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1752						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CTCTTACAGAGTAAATGGCCA	0.478													29	46					0	0	0	0	A	153973462	A	A	153973462	2	1	33	1	0	0	0	0	0	0	0	1	10815	1024	36	4		4	NUP210L	1	153973462	Silent	SNP	G	TCGA-BB-7870-01A-11D-2229-08	35390024	153973462	95277159	5	6221											
SLC19A2	10560	broad.mit.edu	37	chr1	169446778	169446778	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cactgtagatataagagtaaTaggcaatttcagtggctgtg	13	12	11	5	0	1	2	1	0	0	2	1	2	1	2	0	2	0	4	0	2	6	6			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr1:169446778T>C	uc001gge.3	-	2	626	c.422A>G	c.(421-423)TAT>TGT	p.Y141C	SLC19A2_uc001ggf.3_Intron	NM_006996	NP_008927	O60779	S19A2_HUMAN	solute carrier family 19, member 2	141	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity				0	all_hematologic(923;0.208)					ATAAGAGTAATAGGCAATTTC	0.453													8	13					0	0	0	0	C	169446778	C	C	169446778	3	2	33	1	0	0	0	0	1	0	0	0	14494	1406	49	5	1091	5	SLC19A2	1	169446778	Missense_Mutation	SNP	T	TCGA-BB-7870-01A-11D-2229-08	15473316	169446778	79803843	6	6222											
USH2A	7399	broad.mit.edu	37	chr1	216420335	216420335	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagtcccagggagggatcCagctgtgtcacagtcacagg	10	6	14	11	0	2	0	2	0	0	0	4	3	4	2	2	3	1	1	2	3	0	0			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr1:216420335C>T	uc001hku.1	-	13	2788	c.2401G>A	c.(2401-2403)GGA>AGA	p.G801R	USH2A_uc001hkv.2_Missense_Mutation_p.G801R	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	801	Extracellular (Potential).|Laminin EGF-like 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGGAGGGATCCAGCTGTGTCA	0.468										HNSCC(13;0.011)			6	11					0	0	0	0	T	216420335	T	T	216420335	3	4	33	1	0	0	0	0	1	0	0	0	17104	603	21	4	13461	4	USH2A	1	216420335	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08	46973557	216420335	32830286	7	6223											
RHOU	58480	broad.mit.edu	37	chr1	228871725	228871725	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggctaccccaccgagtacaTccctactgccttcgacaact	9	8	6	18	3	0	0	0	0	0	0	2	2	1	0	5	1	5	2	5	1	4	4			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr1:228871725T>A	uc001htf.2	+	1	857	c.236T>A	c.(235-237)ATC>AAC	p.I79N		NM_021205	NP_067028	Q7L0Q8	RHOU_HUMAN	ras homolog gene family, member U	79					regulation of small GTPase mediated signal transduction	cell projection|cytosol|focal adhesion|Golgi membrane|podosome	GTP binding|metal ion binding|protein binding				0	Breast(184;0.162)	Prostate(94;0.183)				ACCGAGTACATCCCTACTGCC	0.488													9	17					0	0	0	0	A	228871725	A	A	228871725	3	1	33	1	0	0	0	0	1	0	0	0	13410	1435	50	5	238	5	RHOU	1	228871725	Missense_Mutation	SNP	T	TCGA-BB-7870-01A-11D-2229-08	12451390	228871725	20378896	8	6224											
GREB1	9687	broad.mit.edu	37	chr2	11737977	11737977	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagctcctctcccatgtGtgttccattgcggattccag	7	12	9	13	1	1	1	0	0	1	1	5	2	4	2	4	1	2	2	4	1	1	3			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr2:11737977G>T	uc002rbk.1	+	14	2325	c.2025G>T	c.(2023-2025)GTG>GTT	p.V675V	GREB1_uc002rbo.1_Silent_p.V309V	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	675						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TCTCCCATGTGTGTTCCATTG	0.557													31	65					1.22384e-17	1.94502e-17	1	0	T	11737977	T	T	11737977	2	4	33	1	0	0	0	0	0	0	0	1	6799	1364	48	4		4	GREB1	2	11737977	Silent	SNP	G	TCGA-BB-7870-01A-11D-2229-08		11737977	231461396	9	6225											
AFF3	3899	broad.mit.edu	37	chr2	100203726	100203726	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttgatctccctgtagtcGtcttcgttgtcacactgtat	5	18	7	11	2	4	1	1	1	3	0	7	1	4	1	1	0	0	3	1	0	2	6			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr2:100203726G>A	uc002tag.2	-	15	2717	c.2481C>T	c.(2479-2481)GAC>GAT	p.D827D	AFF3_uc002taf.2_Silent_p.D852D|AFF3_uc010fiq.1_Silent_p.D827D|AFF3_uc010yvr.1_Silent_p.D980D|AFF3_uc002tah.1_Silent_p.D852D	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	827					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CCCTGTAGTCGTCTTCGTTGT	0.473													15	17					0	0	0	0	A	100203726	A	A	100203726	2	1	33	1	0	0	0	0	0	0	0	1	358	1136	40	1		1	AFF3	2	100203726	Silent	SNP	G	TCGA-BB-7870-01A-11D-2229-08	88465749	100203726	142995647	10	6226											
AFF3	3899	broad.mit.edu	37	chr2	100217970	100217970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctcggtctccgagtcagatCcggagctgctctctgagtcg	5	11	12	13	4	4	2	1	1	3	1	9	4	5	3	2	2	2	2	2	2	0	0			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr2:100217970C>T	uc002tag.2	-	13	1534	c.1298G>A	c.(1297-1299)GGA>GAA	p.G433E	AFF3_uc002taf.2_Missense_Mutation_p.G458E|AFF3_uc010fiq.1_Missense_Mutation_p.G433E|AFF3_uc010yvr.1_Missense_Mutation_p.G586E|AFF3_uc002tah.1_Missense_Mutation_p.G458E	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	433					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CGAGTCAGATCCGGAGCTGCT	0.537													3	4					0	0	0	0	T	100217970	T	T	100217970	3	4	33	1	0	0	0	0	1	0	0	0	358	855	30	2	2430	2	AFF3	2	100217970	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08	14244	100217970	142981403	11	6227											
LRP1B	53353	broad.mit.edu	37	chr2	141473634	141473634	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattgagtcttgcaacttcAattaagttgaaaccatgatc	13	13	6	9	0	2	3	1	3	1	0	3	3	2	3	2	0	3	2	2	0	4	5			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr2:141473634A>T	uc002tvj.1	-	37	6903	c.5931T>A	c.(5929-5931)ATT>ATA	p.I1977I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1977	Extracellular (Potential).|LDL-receptor class B 20.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGCAACTTCAATTAAGTTGA	0.343										TSP Lung(27;0.18)			5	9					0	0	0	0	T	141473634	T	T	141473634	2	4	33	1	0	0	0	0	0	0	0	1	9005	126	5	5		5	LRP1B	2	141473634	Silent	SNP	A	TCGA-BB-7870-01A-11D-2229-08	41255664	141473634	101725739	12	6228											
XRCC5	7520	broad.mit.edu	37	chr2	216972361	216972362	+	5'Flank	DEL	TC	-	-																															cctgtctgtttctttcctttTctctctctctctagctctgg																										TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr2:216972361_216972362delTC	uc002vfy.2	+							NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II						double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		TCTTTCCTTTTCTCTCTCTCTC	0.243								Direct_reversal_of_damage|NHEJ					---	---	---								-	216972362	-	-	216972361	6	5	33	0	1	1	0	1	0	0	0	0	17524	1798	62	0		0	XRCC5	2	216972361	5'Flank	DEL	TC	TCGA-BB-7870-01A-11D-2229-08	75498727	216972361	26227012	13	6229											
WDR69	164781	broad.mit.edu	37	chr2	228786234	228786234	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggggcacactgatgaaatCttttcatgtgctttcaacta	11	13	9	8	0	3	2	2	2	1	0	3	3	3	2	0	2	2	2	0	2	3	4			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr2:228786234C>A	uc002vpn.1	+	12	1249	c.1170C>A	c.(1168-1170)ATC>ATA	p.I390I	WDR69_uc010zlw.1_Silent_p.I375I|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	390	WD 8.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		CTGATGAAATCTTTTCATGTG	0.443													7	6					0.00448238	0.00504977	1	0	A	228786234	A	A	228786234	2	1	33	1	0	0	0	0	0	0	0	1	17387	903	32	2		2	WDR69	2	228786234	Silent	SNP	C	TCGA-BB-7870-01A-11D-2229-08	11813873	228786234	14413139	14	6230											
SIDT1	54847	broad.mit.edu	37	chr3	113320475	113320475	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcatcccattgctgccagCacacccgaagggagcaatta	11	8	8	14	1	1	0	1	0	1	0	3	2	2	1	3	1	4	3	3	1	3	2			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr3:113320475C>A	uc003eak.2	+	11	1737	c.1086C>A	c.(1084-1086)AGC>AGA	p.S362R	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.S362R|SIDT1_uc011big.1_Missense_Mutation_p.S115R|SIDT1_uc011bih.1_5'Flank	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	362	Cytoplasmic (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						TTGCTGCCAGCACACCCGAAG	0.418													5	10					5.18039e-06	6.98568e-06	1	0	A	113320475	A	A	113320475	3	1	33	1	0	0	0	0	1	0	0	0	14367	709	25	4	1128	4	SIDT1	3	113320475	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08		113320475	84701955	15	6231											
AGTR1	185	broad.mit.edu	37	chr3	148459143	148459143	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtaagattgcttcagccagCgtcagtttcaacctgtacgc	9	12	9	11	2	3	1	3	0	0	1	3	1	3	1	2	0	5	4	2	0	3	5			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr3:148459143C>A	uc003ewg.2	+	4	767	c.321C>A	c.(319-321)AGC>AGA	p.S107R	AGTR1_uc003ewh.2_Missense_Mutation_p.S107R|AGTR1_uc003ewi.2_Missense_Mutation_p.S107R|AGTR1_uc003ewj.2_Missense_Mutation_p.S107R|AGTR1_uc003ewk.2_Missense_Mutation_p.S107R	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	107	Helical; Name=3; (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	CTTCAGCCAGCGTCAGTTTCA	0.473													14	23					9.31168e-06	1.23692e-05	1	0	A	148459143	A	A	148459143	3	1	33	1	0	0	0	0	1	0	0	0	401	767	27	3	323	3	AGTR1	3	148459143	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08	35138668	148459143	49563287	16	6232											
CP	1356	broad.mit.edu	37	chr3	148925398	148925398	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacttccaaaagtgtatccaTtcacagctgtaagtcaagag	14	10	8	9	0	2	1	2	0	0	1	4	2	4	1	2	0	1	3	2	0	5	4	rs150303869	byFrequency	TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr3:148925398T>C	uc003ewy.3	-	5	1041	c.788A>G	c.(787-789)AAT>AGT	p.N263S	CP_uc011bnr.1_RNA|CP_uc003ewx.3_Missense_Mutation_p.N44S|CP_uc003ewz.2_Missense_Mutation_p.N263S|CP_uc010hvf.1_5'UTR	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	263	F5/8 type A 1.|Plastocyanin-like 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	AGTGTATCCATTCACAGCTGT	0.373													5	10					0	0	0	0	C	148925398	C	C	148925398	3	2	33	1	0	0	0	0	1	0	0	0	3802	1493	52	5	2469	5	CP	3	148925398	Missense_Mutation	SNP	T	TCGA-BB-7870-01A-11D-2229-08	466255	148925398	49097032	17	6233											
MAP3K13	9175	broad.mit.edu	37	chr3	185167779	185167779	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatctggggtgttggaagcAacagcctccaccttccagtt	8	12	10	11	0	1	0	0	0	1	0	3	1	3	1	4	3	3	3	4	3	3	4			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr3:185167779A>T	uc010hyf.2	+	7	1368	c.1102A>T	c.(1102-1104)AAC>TAC	p.N368Y	MAP3K13_uc011brt.1_Missense_Mutation_p.N161Y|MAP3K13_uc003fph.3_Missense_Mutation_p.N136Y|MAP3K13_uc011bru.1_Missense_Mutation_p.N224Y|MAP3K13_uc003fpi.2_Missense_Mutation_p.N368Y|MAP3K13_uc010hyg.2_Missense_Mutation_p.N58Y	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	368	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TGTTGGAAGCAACAGCCTCCA	0.453													15	7					0	0	0	0	T	185167779	T	T	185167779	3	4	33	1	0	0	0	0	1	0	0	0	9300	130	5	5	1120	5	MAP3K13	3	185167779	Missense_Mutation	SNP	A	TCGA-BB-7870-01A-11D-2229-08	36242381	185167779	12854651	18	6234											
ZNF518B	85460	broad.mit.edu	37	chr4	10447135	10447135	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtaacaacatgatattgTgcattttgtctttatttgca	11	17	7	6	0	1	1	0	1	1	0	1	1	1	1	0	1	4	3	0	1	4	8			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr4:10447135T>C	uc003gmn.2	-	3	1305	c.818A>G	c.(817-819)CAC>CGC	p.H273R		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						CATGATATTGTGCATTTTGTC	0.373													20	32					0	0	0	0	C	10447135	C	C	10447135	3	2	33	1	0	0	0	0	1	0	0	0	18030	1696	59	5	2410	5	ZNF518B	4	10447135	Missense_Mutation	SNP	T	TCGA-BB-7870-01A-11D-2229-08		10447135	180707141	19	6235											
PPARGC1A	10891	broad.mit.edu	37	chr4	23816147	23816147	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggtggcaccacagtcttgCaagaggacttcagctttgga	9	10	13	9	0	2	1	1	0	1	1	2	3	2	3	1	4	2	3	1	4	1	3			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr4:23816147C>A	uc003gqs.2	-	8	1079	c.959G>T	c.(958-960)TGC>TTC	p.C320F	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	320	Interaction with PPARG.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				CACAGTCTTGCAAGAGGACTT	0.488													13	26					2.32078e-09	3.5612e-09	1	0	A	23816147	A	A	23816147	3	1	33	1	0	0	0	0	1	0	0	0	12355	710	25	4	1461	4	PPARGC1A	4	23816147	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08	13369012	23816147	167338129	20	6236											
KIT	3815	broad.mit.edu	37	chr4	55599309	55599309	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cacaaagatttgtgattttgGtctagccagagacatcaaga	14	11	9	7	0	2	4	1	1	1	3	2	5	2	4	1	1	1	0	1	1	3	4			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr4:55599309G>T	uc010igr.2	+	17	2522	c.2435G>T	c.(2434-2436)GGT>GTT	p.G812V	KIT_uc010igs.2_Missense_Mutation_p.G808V	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	812	Protein kinase.|Cytoplasmic (Potential).		G -> V (in PBT).		male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TGTGATTTTGGTCTAGCCAGA	0.393		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				9	22					7.48243e-07	1.02452e-06	1	0	T	55599309	T	T	55599309	3	4	33	1	0	0	0	0	1	0	0	0	8368	1261	44	4	2501	4	KIT	4	55599309	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	31783162	55599309	135554967	21	6237											
SLC4A4	8671	broad.mit.edu	37	chr4	72363397	72363397	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaattcaaaactagtccttaTtttccaaccacagtaagtac	16	12	3	10	0	1	0	1	0	0	0	3	0	3	0	3	0	3	2	3	0	8	7			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr4:72363397T>C	uc003hfy.2	+	16	2271	c.2154T>C	c.(2152-2154)TAT>TAC	p.Y718Y	SLC4A4_uc010iic.2_Silent_p.Y718Y|SLC4A4_uc010iib.2_Silent_p.Y718Y|SLC4A4_uc003hfz.2_Silent_p.Y718Y|SLC4A4_uc003hgc.3_Silent_p.Y674Y|SLC4A4_uc010iid.2_Intron	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	718	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CTAGTCCTTATTTTCCAACCA	0.343													8	10					0	0	0	0	C	72363397	C	C	72363397	2	2	33	1	0	0	0	0	0	0	0	1	14720	1500	52	5		5	SLC4A4	4	72363397	Silent	SNP	T	TCGA-BB-7870-01A-11D-2229-08	16764088	72363397	118790879	22	6238											
FAT4	79633	broad.mit.edu	37	chr4	126337709	126337709	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctcagccagtggagaacttgGagtaacacagagtctggatc	12	8	12	9	0	2	2	1	0	1	2	3	5	2	4	1	3	3	1	1	3	2	2			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr4:126337709G>T	uc003ifj.3	+	6	6950	c.6950G>T	c.(6949-6951)GGA>GTA	p.G2317V	FAT4_uc011cgp.1_Missense_Mutation_p.G615V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2317	Extracellular (Potential).|Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGAGAACTTGGAGTAACACAG	0.413													14	18					3.27435e-08	4.5534e-08	1	0	T	126337709	T	T	126337709	3	4	33	1	0	0	0	0	1	0	0	0	5724	1174	41	2	6972	2	FAT4	4	126337709	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	53974312	126337709	64816567	23	6239											
ZNF330	27309	broad.mit.edu	37	chr4	142150788	142150788	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaaatgtctcagtacacatGcttgtgcctgccctcttacc	8	12	8	13	0	2	0	1	0	2	0	3	1	2	1	3	1	5	2	3	1	3	3			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr4:142150788G>T	uc003iiq.3	+	6	575	c.355G>T	c.(355-357)GCT>TCT	p.A119S	ZNF330_uc011chl.1_Missense_Mutation_p.A59S	NM_014487	NP_055302	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	119						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)					CAGTACACATGCTTGTGCCTG	0.443													28	25					9.78306e-22	1.58308e-21	1	0	T	142150788	T	T	142150788	3	4	33	1	0	0	0	0	1	0	0	0	17915	1319	46	4	373	4	ZNF330	4	142150788	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	15813079	142150788	49003488	24	6240											
CTNND2	1501	broad.mit.edu	37	chr5	11199589	11199589	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcccggatctccaggtcaGtcgtcttgcggagtaacctc	6	10	11	14	3	3	0	1	0	2	0	7	2	4	2	3	3	2	2	3	3	1	2			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr5:11199589G>C	uc003jfa.1	-	11	2091	c.1946C>G	c.(1945-1947)ACT>AGT	p.T649S	CTNND2_uc010itt.2_Missense_Mutation_p.T558S|CTNND2_uc011cmy.1_Missense_Mutation_p.T312S|CTNND2_uc011cmz.1_Missense_Mutation_p.T216S|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.T216S	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	649	ARM 4.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CTCCAGGTCAGTCGTCTTGCG	0.428													22	56					0	0	0	0	C	11199589	C	C	11199589	3	2	33	1	0	0	0	0	1	0	0	0	4037	1029	36	4	1779	4	CTNND2	5	11199589	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08		11199589	169715671	25	6241											
PDZD2	23037	broad.mit.edu	37	chr5	31983413	31983413	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagctgggtgaccgaactgCgaaaaaggggaaacgaacca	15	3	15	8	3	0	1	0	1	0	0	0	6	0	3	2	4	5	1	2	4	5	0			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr5:31983413C>T	uc003jhl.2	+	3	1017	c.629C>T	c.(628-630)GCG>GTG	p.A210V	PDZD2_uc003jhm.2_Missense_Mutation_p.A210V|PDZD2_uc011cnx.1_Missense_Mutation_p.A36V	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	210					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus		p.A210V(1)		central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GACCGAACTGCGAAAAAGGGG	0.542													6	10					0	0	0	0	T	31983413	T	T	31983413	3	4	33	1	0	0	0	0	1	0	0	0	11755	768	27	1	635	1	PDZD2	5	31983413	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08	20783824	31983413	148931847	26	6242											
PIK3R1	5295	broad.mit.edu	37	chr5	67589623	67589634	+	In_Frame_Del	DEL	ATATGATAGATT	-	-																															tttcaagaaaaaagtcgagaAtatgatagattatatgaaga																										TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr5:67589623_67589634delATATGATAGATT	uc003jva.2	+	11	1946_1957	c.1386_1397delATATGATAGATT	c.(1384-1398)GAATATGATAGATTA>GAA	p.YDRL463del	PIK3R1_uc003jvb.2_In_Frame_Del_p.YDRL463del|PIK3R1_uc003jvc.2_In_Frame_Del_p.YDRL163del|PIK3R1_uc003jvd.2_In_Frame_Del_p.YDRL193del|PIK3R1_uc003jve.2_In_Frame_Del_p.YDRL142del|PIK3R1_uc011crb.1_In_Frame_Del_p.YDRL133del	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	463_466					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.D464fs*2(1)|p.?(1)|p.D464H(1)|p.Y463fs*1(1)|p.Y463_L466del(1)|p.T454_D464del(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AAAGTCGAGAATATGATAGATTATATGAAGAA	0.283			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			---	---	---								-	67589634	-	-	67589623	7	5	33	1	0	1	0	1	0	0	0	0	11973	98	4	0	1554	0	PIK3R1	5	67589623	In_Frame_Del	DEL	ATATGATAGATT	TCGA-BB-7870-01A-11D-2229-08	35606210	67589623	113325637	27	6243											
PCDHA7	56141	broad.mit.edu	37	chr5	140216084	140216085	+	Frame_Shift_Ins	INS	-	A	A																															cctgatcatcgccatctgcgINScggtgtccagtctgttggtg																								rs138671187		TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr5:140216084_140216085insA	uc003lhq.2	+	1	2116_2117	c.2116_2117insA	c.(2116-2118)GCGfs	p.A706fs	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Frame_Shift_Ins_p.A706fs	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	706	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCATCTGCGCGGTGTCCAGT	0.619													---	---	---								A	140216085	A	A	140216084	7	5	33	1	0	1	1	0	0	0	0	0	11583	1087	38	0	2118	0	PCDHA7	5	140216084	Frame_Shift_Ins	INS	-	TCGA-BB-7870-01A-11D-2229-08	72626461	140216084	40699176	28	6244											
PCDHGA7	56108	broad.mit.edu	37	chr5	140762628	140762628	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcgccaaggacctggggctGgagccccgggagctggcgga	7	4	18	12	3	0	0	0	0	0	0	1	4	0	4	4	7	2	2	4	7	1	0			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr5:140762628G>T	uc003lka.1	+	1	162	c.162G>T	c.(160-162)CTG>CTT	p.L54L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Silent_p.L54L	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	54	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTGGGGCTGGAGCCCCGGG	0.652													5	5					0.000157383	0.000194543	1	0	T	140762628	T	T	140762628	2	4	33	1	0	0	0	0	0	0	0	1	11613	1335	47	4		4	PCDHGA7	5	140762628	Silent	SNP	G	TCGA-BB-7870-01A-11D-2229-08	546544	140762628	40152632	29	6245											
LARP1	23367	broad.mit.edu	37	chr5	154193517	154193517	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggtggcggcggtgagggcaGgaagcggtgcccctcccagt	6	5	19	11	3	0	1	0	1	0	0	1	2	1	2	3	7	2	1	3	7	1	0			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr5:154193517G>T	uc003lvp.2	+	19	3581	c.3152G>T	c.(3151-3153)AGG>ATG	p.R1051M	LARP1_uc003lvo.2_Missense_Mutation_p.R974M	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	1051							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GGTGAGGGCAGGAAGCGGTGC	0.642													10	18					0.00010058	0.00012788	1	0	T	154193517	T	T	154193517	3	4	33	1	0	0	0	0	1	0	0	0	8668	1000	35	4	2995	4	LARP1	5	154193517	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	13430889	154193517	26721743	30	6246											
NSD1	64324	broad.mit.edu	37	chr5	176638368	176638368	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgactctgcattatctggcGagttgtctgcttccctacct	5	15	9	12	1	3	1	0	1	3	0	4	2	4	1	2	1	3	3	2	1	2	4	rs138673583		TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr5:176638368G>T	uc003mfr.3	+	5	3106	c.2968G>T	c.(2968-2970)GAG>TAG	p.E990*	NSD1_uc003mft.3_Nonsense_Mutation_p.E721*|NSD1_uc003mfs.1_Nonsense_Mutation_p.E887*|NSD1_uc011dfx.1_Nonsense_Mutation_p.E638*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	990					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ATTATCTGGCGAGTTGTCTGC	0.527			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			13	10					3.27435e-08	4.5534e-08	1	0	T	176638368	T	T	176638368	4	4	33	1	0	0	0	0	0	1	0	0	10723	1059	37	3	2982	3	NSD1	5	176638368	Nonsense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	22444851	176638368	4276892	31	6247											
DSP	1832	broad.mit.edu	37	chr6	7584607	7584607	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattcgcttattagaagcacAgatcgcaaccggggggatca	12	9	11	9	3	1	2	1	0	0	2	3	3	1	3	1	3	2	3	1	3	5	4			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr6:7584607A>G	uc003mxp.1	+	24	7391	c.7112A>G	c.(7111-7113)CAG>CGG	p.Q2371R	DSP_uc003mxq.1_Missense_Mutation_p.Q1772R	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2371	Plectin 10.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TTAGAAGCACAGATCGCAACC	0.443													8	10					0	0	0	0	G	7584607	G	G	7584607	3	3	33	1	0	0	0	0	1	0	0	0	4803	188	7	5	7206	5	DSP	6	7584607	Missense_Mutation	SNP	A	TCGA-BB-7870-01A-11D-2229-08		7584607	163530460	32	6248											
POPDC3	64208	broad.mit.edu	37	chr6	105606552	105606552	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcgggagatgtagcgatgCtgagcaaagagcagatataa	15	6	15	5	2	0	4	0	1	0	3	0	6	0	4	0	2	4	4	0	2	4	3			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr6:105606552C>T	uc003prb.2	-	4	1071	c.669G>A	c.(667-669)CAG>CAA	p.Q223Q	uc003pqz.2_Intron|POPDC3_uc003pra.2_RNA	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	223						integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				TGTAGCGATGCTGAGCAAAGA	0.393													21	51					0	0	0	0	T	105606552	T	T	105606552	2	4	33	1	0	0	0	0	0	0	0	1	12311	796	28	4		4	POPDC3	6	105606552	Silent	SNP	C	TCGA-BB-7870-01A-11D-2229-08	98021945	105606552	65508515	33	6249											
RGS17	26575	broad.mit.edu	37	chr6	153347667	153347667	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcccctctttcttcattcCtcacagtgaggctgtaatgt	6	17	6	12	0	4	1	2	1	2	0	6	1	6	1	3	1	0	2	3	1	1	5			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr6:153347667C>T	uc003qpm.2	-	3	287	c.131G>A	c.(130-132)AGG>AAG	p.R44K		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	44					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		TTCTTCATTCCTCACAGTGAG	0.403									Lung_Cancer_Familial_Clustering_of				17	39					0	0	0	0	T	153347667	T	T	153347667	3	4	33	1	0	0	0	0	1	0	0	0	13364	681	24	4	513	4	RGS17	6	153347667	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08	47741115	153347667	17767400	34	6250											
ZNF479	90827	broad.mit.edu	37	chr7	57188501	57188501	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgtaggacttctccctagtAtgaattacctgatgttgatt	9	17	8	7	0	1	3	0	3	1	0	2	4	1	4	2	1	1	3	2	1	5	8			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr7:57188501A>G	uc010kzo.2	-	5	892	c.621T>C	c.(619-621)CAT>CAC	p.H207H		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	207	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TCTCCCTAGTATGAATTACCT	0.328													2	0					0	0	0	0	G	57188501	G	G	57188501	2	3	33	1	0	0	0	0	0	0	0	1	18000	446	16	5		5	ZNF479	7	57188501	Silent	SNP	A	TCGA-BB-7870-01A-11D-2229-08		57188501	101950162	35	6251											
SGK223	157285	broad.mit.edu	37	chr8	8234718	8234718	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggctgtgtagcctcccgggGgtgggccgggggctggggct	2	7	22	10	2	0	0	0	0	0	0	1	0	1	0	3	8	1	4	3	8	1	1			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr8:8234718G>T	uc003wsh.3	-	2	1201	c.1201C>A	c.(1201-1203)CCC>ACC	p.P401T		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	401							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GCCTCCCGGGGGTGGGCCGGG	0.642													7	9					0.00448238	0.00504977	1	0	T	8234718	T	T	8234718	3	4	33	1	0	0	0	0	1	0	0	0	14275	1232	43	4	3023	4	SGK223	8	8234718	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08		8234718	138129304	36	6252											
KCNU1	157855	broad.mit.edu	37	chr8	36693861	36693861	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccaccagaatcatcatacAgatactgcaatcccataaca	17	8	3	13	0	2	2	2	0	0	2	3	2	3	2	3	0	5	1	3	0	6	4			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr8:36693861A>G	uc010lvw.2	+	13	1430	c.1343A>G	c.(1342-1344)CAG>CGG	p.Q448R	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	448	RCK N-terminal.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ATCATCATACAGATACTGCAA	0.358													12	22					0	0	0	0	G	36693861	G	G	36693861	3	3	33	1	0	0	0	0	1	0	0	0	8132	188	7	5	1393	5	KCNU1	8	36693861	Missense_Mutation	SNP	A	TCGA-BB-7870-01A-11D-2229-08	28459143	36693861	109670161	37	6253											
ANK3	288	broad.mit.edu	37	chr10	61831145	61831145	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtttctggggttaaagggCttttcccagagctgtctaga	7	14	13	7	0	2	2	0	0	2	2	3	2	3	2	1	3	1	4	1	3	3	5			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr10:61831145C>T	uc001jky.2	-	37	9686	c.9494G>A	c.(9493-9495)AGC>AAC	p.S3165N	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3165					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGTTAAAGGGCTTTTCCCAGA	0.438													3	2					0	0	0	0	T	61831145	T	T	61831145	3	4	33	1	0	0	0	0	1	0	0	0	622	797	28	4	3980	4	ANK3	10	61831145	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08		61831145	73703602	38	6254											
PDCD11	22984	broad.mit.edu	37	chr10	105172881	105172881	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttttgtctaggtgagggcCtgcatcctttgcgtccatcc	4	14	10	13	1	1	1	0	1	1	0	4	1	4	1	5	2	2	1	5	2	1	4			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr10:105172881C>T	uc001kwy.1	+	9	1074	c.987C>T	c.(985-987)GCC>GCT	p.A329A		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	329	S1 motif 3.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		AGGTGAGGGCCTGCATCCTTT	0.587													7	6					0	0	0	0	T	105172881	T	T	105172881	2	4	33	1	0	0	0	0	0	0	0	1	11671	668	24	4		4	PDCD11	10	105172881	Silent	SNP	C	TCGA-BB-7870-01A-11D-2229-08	43341736	105172881	30361866	39	6255											
OR51V1	283111	broad.mit.edu	37	chr11	5221625	5221625	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggcaatgcaggaatccaaGctgatctctcgaatgatccc	11	9	10	11	1	1	2	0	2	1	0	5	4	3	3	2	2	2	3	2	2	4	0			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr11:5221625G>C	uc010qyz.1	-	1	306	c.306C>G	c.(304-306)AGC>AGG	p.S102R		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	102	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGAATCCAAGCTGATCTCTC	0.522													6	6					0	0	0	0	C	5221625	C	C	5221625	3	2	33	1	0	0	0	0	1	0	0	0	11161	962	34	4	662	4	OR51V1	11	5221625	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08		5221625	129784891	40	6256											
PLEKHA7	144100	broad.mit.edu	37	chr11	16838753	16838753	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacttggcaggtttcggggaGgtggcgaggagccccccgag	6	6	18	11	3	0	0	0	0	0	0	1	4	0	2	3	7	1	2	3	7	0	2			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr11:16838753G>A	uc001mmo.2	-	11	1475	c.1460C>T	c.(1459-1461)CCT>CTT	p.P487L	PLEKHA7_uc010rcu.1_Missense_Mutation_p.P487L|PLEKHA7_uc010rcv.1_Missense_Mutation_p.P61L|PLEKHA7_uc001mmn.2_Missense_Mutation_p.P195L	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	487					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						GTTTCGGGGAGGTGGCGAGGA	0.637													16	27					0	0	0	0	A	16838753	A	A	16838753	3	1	33	1	0	0	0	0	1	0	0	0	12116	1000	35	4	1957	4	PLEKHA7	11	16838753	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	11617128	16838753	118167763	41	6257											
LRRC4C	57689	broad.mit.edu	37	chr11	40136523	40136523	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttgctgcagtaacattcagGgtggctgaagcagtagtatt	10	12	13	6	0	1	1	1	1	0	0	1	1	1	1	0	2	4	8	0	2	4	6			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr11:40136523G>T	uc001mxa.1	-	2	3284	c.1320C>A	c.(1318-1320)ACC>ACA	p.T440T	LRRC4C_uc001mxc.1_Silent_p.T436T|LRRC4C_uc001mxd.1_Silent_p.T436T|LRRC4C_uc001mxb.1_Silent_p.T436T	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	440	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TAACATTCAGGGTGGCTGAAG	0.443													9	16					2.80697e-09	4.16368e-09	1	0	T	40136523	T	T	40136523	2	4	33	1	0	0	0	0	0	0	0	1	9058	1219	43	4		4	LRRC4C	11	40136523	Silent	SNP	G	TCGA-BB-7870-01A-11D-2229-08	23297770	40136523	94869993	42	6258											
GRIK4	2900	broad.mit.edu	37	chr11	120776131	120776131	+	Frame_Shift_Del	DEL	G	-	-																															actacaagatccgcctggttGgggatggcgtgtacggcgtt																										TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr11:120776131delG	uc001pxn.2	+	13	1692	c.1405delG	c.(1405-1407)GGGfs	p.G469fs	GRIK4_uc009zav.1_Frame_Shift_Del_p.G469fs|GRIK4_uc009zaw.1_Frame_Shift_Del_p.G469fs|GRIK4_uc009zax.1_Frame_Shift_Del_p.G469fs	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	469	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CCGCCTGGTTGGGGATGGCGT	0.597													---	---	---								-	120776131	-	-	120776131	7	5	33	1	0	1	0	1	0	0	0	0	6815	1348	47	0	1447	0	GRIK4	11	120776131	Frame_Shift_Del	DEL	G	TCGA-BB-7870-01A-11D-2229-08	80639608	120776131	14230385	43	6259											
GUCY2C	2984	broad.mit.edu	37	chr12	14766103	14766103	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagctgcaagtattccagaGtgccttttttatagctggct	8	15	9	9	0	1	1	1	0	0	1	2	1	2	1	2	1	4	5	2	1	4	6			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr12:14766103G>T	uc001rcd.2	-	27	3307	c.3170C>A	c.(3169-3171)ACT>AAT	p.T1057N		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	1057	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						GTATTCCAGAGTGCCTTTTTT	0.413													14	25					4.7546e-09	6.93705e-09	1	0	T	14766103	T	T	14766103	3	4	33	1	0	0	0	0	1	0	0	0	6935	1029	36	4	55	4	GUCY2C	12	14766103	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08		14766103	119085792	44	6260											
MLL2	8085	broad.mit.edu	37	chr12	49422696	49422696	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgacaggcagctttccaGggacctccaggccaagggcc	8	7	13	13	0	0	1	0	1	0	0	2	2	2	2	5	4	1	2	5	4	1	2			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr12:49422696G>A	uc001rta.3	-	45	14297	c.14297C>T	c.(14296-14298)CCT>CTT	p.P4766L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4766					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CAGCTTTCCAGGGACCTCCAG	0.547			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			11	25					0	0	0	0	A	49422696	A	A	49422696	3	1	33	1	0	0	0	0	1	0	0	0	9674	1000	35	4	2356	4	MLL2	12	49422696	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	34656593	49422696	84429199	45	6261											
KRT6C	286887	broad.mit.edu	37	chr12	52864970	52864970	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcctctgagcaatctcctcGtattgggccttgacctcagc	6	12	8	15	1	3	2	1	2	2	0	6	2	4	2	4	1	2	2	4	1	2	3	rs11540289	byFrequency	TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr12:52864970G>C	uc001sal.3	-	5	1071	c.1023C>G	c.(1021-1023)TAC>TAG	p.Y341*		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	341	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		CAATCTCCTCGTATTGGGCCT	0.572													25	67					0	0	0	0	C	52864970	C	C	52864970	4	2	33	1	0	0	0	0	0	1	0	0	8521	1140	40	3	691	3	KRT6C	12	52864970	Nonsense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	3442274	52864970	80986925	46	6262											
NEUROD4	58158	broad.mit.edu	37	chr12	55420705	55420705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtggagatgctgtgtaaagGgctctctcagcccacaagca	10	9	12	10	0	2	1	1	0	1	1	3	2	2	1	1	2	3	4	1	2	3	1			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr12:55420705G>A	uc001sgp.3	+	2	860	c.482G>A	c.(481-483)GGG>GAG	p.G161E		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	161					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						CTGTGTAAAGGGCTCTCTCAG	0.517													5	10					0	0	0	0	A	55420705	A	A	55420705	3	1	33	1	0	0	0	0	1	0	0	0	10404	1232	43	4	484	4	NEUROD4	12	55420705	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	2555735	55420705	78431190	47	6263											
ARHGAP9	64333	broad.mit.edu	37	chr12	57866398	57866398	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgtctcctgctctggccGaaacagggttggtccaaaca	10	9	11	11	1	2	1	0	0	2	1	4	2	3	1	3	3	3	2	3	3	2	1			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr12:57866398G>T	uc001sod.2	-	21	2561	c.2368C>A	c.(2368-2370)CGG>AGG	p.R790R	ARHGAP9_uc001sny.2_RNA|ARHGAP9_uc001snz.2_Silent_p.R516R|ARHGAP9_uc001soa.2_Silent_p.R389R|ARHGAP9_uc001sob.2_3'UTR|ARHGAP9_uc001soc.2_Silent_p.R700R	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	719	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			TGCTCTGGCCGAAACAGGGTT	0.552													8	12					0.000157383	0.000194543	1	0	T	57866398	T	T	57866398	2	4	33	1	0	0	0	0	0	0	0	1	889	1057	37	3		3	ARHGAP9	12	57866398	Silent	SNP	G	TCGA-BB-7870-01A-11D-2229-08	2445693	57866398	75985497	48	6264											
PTPRR	5801	broad.mit.edu	37	chr12	71158516	71158516	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cactccttggcggaagatccGaagcaaggttatgttcagct	10	10	11	10	2	1	1	1	0	0	1	3	3	3	2	2	3	2	4	2	3	4	3	rs139968754	byFrequency	TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr12:71158516G>C	uc001swi.1	-	3	816	c.400C>G	c.(400-402)CGG>GGG	p.R134G	PTPRR_uc010stq.1_Missense_Mutation_p.R22G	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	134	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CGGAAGATCCGAAGCAAGGTT	0.383													9	20					0	0	0	0	C	71158516	C	C	71158516	3	2	33	1	0	0	0	0	1	0	0	0	12875	1057	37	3	1621	3	PTPRR	12	71158516	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	13292118	71158516	62693379	49	6265											
SYT1	6857	broad.mit.edu	37	chr12	79611319	79611319	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggtgagcgagagtcaccAtgaggccctggcagccccgc	9	5	14	13	2	1	3	1	2	0	1	1	4	1	3	4	3	2	1	4	3	1	0			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr12:79611319A>G	uc001sys.2	+	5	691	c.20A>G	c.(19-21)CAT>CGT	p.H7R	SYT1_uc001syt.2_Missense_Mutation_p.H7R|SYT1_uc001syu.2_Missense_Mutation_p.H7R|SYT1_uc001syv.2_Missense_Mutation_p.H7R	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	7	Vesicular (Potential).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						GAGAGTCACCATGAGGCCCTG	0.537													7	10					0	0	0	0	G	79611319	G	G	79611319	3	3	33	1	0	0	0	0	1	0	0	0	15531	217	8	5	22	5	SYT1	12	79611319	Missense_Mutation	SNP	A	TCGA-BB-7870-01A-11D-2229-08	8452803	79611319	54240576	50	6266											
HS6ST3	266722	broad.mit.edu	37	chr13	97485339	97485339	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagggaccgccagaagcggCgggaggagcggaggctgcag	10	1	21	9	4	0	2	0	0	0	2	0	6	0	6	2	6	3	2	2	6	1	0			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr13:97485339C>A	uc001vmw.2	+	2	1327	c.1303C>A	c.(1303-1305)CGG>AGG	p.R435R		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	435	Lumenal (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					CCAGAAGCGGCGGGAGGAGCG	0.597													8	6					0.000442599	0.000539607	1	0	A	97485339	A	A	97485339	2	1	33	1	0	0	0	0	0	0	0	1	7411	759	27	3		3	HS6ST3	13	97485339	Silent	SNP	C	TCGA-BB-7870-01A-11D-2229-08		97485339	17684539	51	6267											
SCFD1	23256	broad.mit.edu	37	chr14	31112596	31112596	+	Frame_Shift_Del	DEL	T	-	-																															tagttgacagcctcttctgcTtttttgttactctgggtaag																								rs35121540		TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr14:31112596delT	uc001wqm.1	+	7	622	c.598delT	c.(598-600)TTTfs	p.F200fs	SCFD1_uc001wqn.1_Frame_Shift_Del_p.F133fs|SCFD1_uc010tpg.1_Frame_Shift_Del_p.F141fs|SCFD1_uc010tph.1_Frame_Shift_Del_p.F15fs|SCFD1_uc010amf.1_Frame_Shift_Del_p.F15fs|SCFD1_uc010tpi.1_Frame_Shift_Del_p.F108fs|SCFD1_uc010amd.1_5'UTR|SCFD1_uc010ame.1_Frame_Shift_Del_p.F133fs	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	200					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		CCTCTTCTGCTTTTTTGTTAC	0.338													---	---	---								-	31112596	-	-	31112596	7	5	33	1	0	1	0	1	0	0	0	0	13954	1609	56	0	624	0	SCFD1	14	31112596	Frame_Shift_Del	DEL	T	TCGA-BB-7870-01A-11D-2229-08		31112596	76236944	52	6268											
GABRB3	2562	broad.mit.edu	37	chr15	26792997	26792997	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagaaaaagtgaatggaaaCacgatcctggaccatctgtc	16	7	10	8	1	1	2	0	1	1	1	3	6	2	4	2	2	1	0	2	2	4	0			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr15:26792997C>A	uc001zaz.2	-	9	1507	c.1365G>T	c.(1363-1365)GTG>GTT	p.V455V	GABRB3_uc010uae.1_Silent_p.V370V|GABRB3_uc001zba.2_Silent_p.V455V|GABRB3_uc001zbb.2_Silent_p.V511V	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	455	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TGAATGGAAACACGATCCTGG	0.393													5	5					0.000602214	0.000714628	1	0	A	26792997	A	A	26792997	2	1	33	1	0	0	0	0	0	0	0	1	6202	465	17	4		4	GABRB3	15	26792997	Silent	SNP	C	TCGA-BB-7870-01A-11D-2229-08		26792997	75738395	53	6269											
GANC	2595	broad.mit.edu	37	chr15	42631928	42631928	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagtgcgttggtaccaggcTggagcctaccagcccttctt	6	11	11	13	1	1	0	0	0	1	0	1	1	1	1	4	3	5	3	4	3	3	6	rs36023127	byFrequency	TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr15:42631928T>C	uc001zpi.2	+	17	2219	c.1905T>C	c.(1903-1905)GCT>GCC	p.A635A		NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	635					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity	p.A635A(1)		central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GGTACCAGGCTGGAGCCTACC	0.567													8	11					0	0	0	0	C	42631928	C	C	42631928	2	2	33	1	0	0	0	0	0	0	0	1	6269	1567	55	5		5	GANC	15	42631928	Silent	SNP	T	TCGA-BB-7870-01A-11D-2229-08	15838931	42631928	59899464	54	6270											
PPP4C	5531	broad.mit.edu	37	chr16	30093844	30093844	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacaattctatgacctcaaaGagctgttcagagtaagagtg	14	10	10	7	0	3	4	2	1	1	3	3	5	3	4	1	0	1	3	1	0	4	4			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr16:30093844G>C	uc002dwe.2	+	4	334	c.190G>C	c.(190-192)GAG>CAG	p.E64Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|PPP4C_uc002dwf.2_Missense_Mutation_p.E64Q|PPP4C_uc002dwg.2_RNA|PPP4C_uc002dwh.2_5'UTR	NM_002720	NP_002711	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	64				E->K: Abolishes interaction with PPP4R4.	microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			skin(1)	1						TGACCTCAAAGAGCTGTTCAG	0.537													6	11					0	0	0	0	C	30093844	C	C	30093844	3	2	33	1	0	0	0	0	1	0	0	0	12462	943	33	2	200	2	PPP4C	16	30093844	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08		30093844	60260909	55	6271											
TP53	7157	broad.mit.edu	37	chr17	7578255	7578255	+	Frame_Shift_Del	DEL	T	-	-																															tactccacacgcaaatttccTtccactcggataagatgctg																										TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr17:7578255delT	uc002gim.2	-	6	788	c.594delA	c.(592-594)GAAfs	p.E198fs	TP53_uc002gig.1_Frame_Shift_Del_p.E198fs|TP53_uc002gih.2_Frame_Shift_Del_p.E198fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.E66fs|TP53_uc010cng.1_Frame_Shift_Del_p.E66fs|TP53_uc002gii.1_Frame_Shift_Del_p.E66fs|TP53_uc010cnh.1_Frame_Shift_Del_p.E198fs|TP53_uc010cni.1_Frame_Shift_Del_p.E198fs|TP53_uc002gij.2_Frame_Shift_Del_p.E198fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.E105fs|TP53_uc002gio.2_Frame_Shift_Del_p.E66fs|TP53_uc010vug.1_Frame_Shift_Del_p.E159fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	198	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> G (in sporadic cancers; somatic mutation).|E -> D (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E198*(17)|p.0?(7)|p.E198K(4)|p.G199fs*48(3)|p.E198Q(2)|p.E198fs*11(2)|p.E198_L201>V(1)|p.K164_P219del(1)|p.G67fs*>24(1)|p.E198_G199ins21(1)|p.E198fs*7(1)|p.E198G(1)|p.G106fs*48(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.E198fs*49(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAAATTTCCTTCCACTCGGA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578255	-	-	7578255	7	5	33	1	0	1	0	1	0	0	0	0	16448	1606	56	0	700	0	TP53	17	7578255	Frame_Shift_Del	DEL	T	TCGA-BB-7870-01A-11D-2229-08		7578255	73616955	56	6272											
MYOCD	93649	broad.mit.edu	37	chr17	12656076	12656076	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcacccgtccccagtccacGtgtgcacggaggaaagtctc	8	7	11	15	3	1	0	0	0	1	0	4	2	3	2	4	2	2	2	4	2	1	0	rs149104165	byFrequency	TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr17:12656076G>T	uc002gnn.2	+	10	1770	c.1471G>T	c.(1471-1473)GTG>TTG	p.V491L	MYOCD_uc002gno.2_Missense_Mutation_p.V491L|MYOCD_uc002gnp.1_Missense_Mutation_p.V395L|MYOCD_uc002gnq.2_Missense_Mutation_p.V210L	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	491	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CCCAGTCCACGTGTGCACGGA	0.612													5	4					0.00198382	0.00229298	1	0	T	12656076	T	T	12656076	3	4	33	1	0	0	0	0	1	0	0	0	10140	1145	40	3	1509	3	MYOCD	17	12656076	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	5077821	12656076	68539134	57	6273											
ZNF750	79755	broad.mit.edu	37	chr17	80790186	80790186	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagtaatcgagtttttacAaagaccatacttcatgtgat	15	14	6	6	1	1	2	1	1	0	1	2	3	1	2	1	0	2	2	1	0	6	7			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr17:80790186A>G	uc002kga.2	-	2	456	c.145T>C	c.(145-147)TGT>CGT	p.C49R	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	49						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GAGTTTTTACAAAGACCATAC	0.438													8	18					0	0	0	0	G	80790186	G	G	80790186	3	3	33	1	0	0	0	0	1	0	0	0	18199	130	5	5	2034	5	ZNF750	17	80790186	Missense_Mutation	SNP	A	TCGA-BB-7870-01A-11D-2229-08	68134110	80790186	405024	58	6274											
EPB41L3	23136	broad.mit.edu	37	chr18	5394711	5394711	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatcttctggtgtgatctCtgtctctttatggaccacta	6	17	7	11	0	4	1	0	1	4	0	7	2	5	2	2	2	0	0	2	2	2	4			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr18:5394711C>A	uc002kmt.1	-	22	3321	c.3235G>T	c.(3235-3237)GAG>TAG	p.E1079*	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Nonsense_Mutation_p.E857*|EPB41L3_uc010dkq.1_Nonsense_Mutation_p.E748*|EPB41L3_uc002kms.1_Nonsense_Mutation_p.E314*|EPB41L3_uc010wze.1_Nonsense_Mutation_p.E384*|EPB41L3_uc010wzf.1_Nonsense_Mutation_p.E376*|EPB41L3_uc010wzg.1_Nonsense_Mutation_p.E351*|EPB41L3_uc010dkr.2_Nonsense_Mutation_p.E471*	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1079	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GGTGTGATCTCTGTCTCTTTA	0.527													19	26					1.64293e-13	2.56528e-13	1	0	A	5394711	A	A	5394711	4	1	33	1	0	0	0	0	0	1	0	0	5178	922	32	2	32	2	EPB41L3	18	5394711	Nonsense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08		5394711	72682537	59	6275											
ANKRD30B	374860	broad.mit.edu	37	chr18	14763758	14763758	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgacacggctgaaagcttGctggaaaaaacacctgacga	14	6	10	11	2	0	3	0	3	0	0	0	5	0	4	2	2	3	3	2	2	4	1			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr18:14763758G>T	uc010dlo.2	+	7	1074	c.894G>T	c.(892-894)TTG>TTT	p.L298F	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	298										ovary(1)|skin(1)	2						CTGAAAGCTTGCTGGAAAAAA	0.483													9	1					1.12685e-05	1.47485e-05	1	0	T	14763758	T	T	14763758	3	4	33	1	0	0	0	0	1	0	0	0	659	1310	46	4	920	4	ANKRD30B	18	14763758	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	9369047	14763758	63313490	60	6276											
DCC	1630	broad.mit.edu	37	chr18	50451655	50451655	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacttgcttatctccaatgtGacagatgatgacagtggaat	13	12	9	7	0	1	4	0	3	1	1	2	5	1	5	1	1	2	1	1	1	4	2			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr18:50451655G>C	uc002lfe.1	+	5	1487	c.900G>C	c.(898-900)GTG>GTC	p.V300V	DCC_uc010xdr.1_Silent_p.V148V	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	300	Extracellular (Potential).|Ig-like C2-type 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCTCCAATGTGACAGATGATG	0.378													12	17					0	0	0	0	C	50451655	C	C	50451655	2	2	33	1	0	0	0	0	0	0	0	1	4299	1277	45	2		2	DCC	18	50451655	Silent	SNP	G	TCGA-BB-7870-01A-11D-2229-08	35687897	50451655	27625593	61	6277											
KEAP1	9817	broad.mit.edu	37	chr19	10610642	10610642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcccctgccccctcagggCactgtgactgcaggggcagg	5	6	14	16	1	1	1	1	1	0	0	2	1	2	1	4	4	2	3	4	4	0	0			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr19:10610642C>T	uc002moq.1	-	2	224	c.68G>A	c.(67-69)TGC>TAC	p.C23Y	KEAP1_uc002mor.1_Missense_Mutation_p.C23Y	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	23			C -> Y (in a breast cancer sample; somatic mutation).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding	p.C23Y(1)		lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCCCTCAGGGCACTGTGACTG	0.652													9	18					0	0	0	0	T	10610642	T	T	10610642	3	4	33	1	0	0	0	0	1	0	0	0	8180	710	25	4	1826	4	KEAP1	19	10610642	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08		10610642	48518341	62	6278											
CACNA1A	773	broad.mit.edu	37	chr19	13411423	13411423	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgccacctccttggctttCtgtagggcaagtttctggtt	4	16	10	11	0	3	0	0	0	3	0	4	0	4	0	3	3	1	5	3	3	2	5			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr19:13411423C>T	uc010dze.2	-	18	2459	c.2223G>A	c.(2221-2223)CAG>CAA	p.Q741Q	CACNA1A_uc010dzc.2_Silent_p.Q266Q|CACNA1A_uc002mwy.3_Silent_p.Q740Q|CACNA1A_uc010xne.1_Silent_p.Q269Q	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	741	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCTTGGCTTTCTGTAGGGCAA	0.522													16	22					0	0	0	0	T	13411423	T	T	13411423	2	4	33	1	0	0	0	0	0	0	0	1	2550	912	32	2		2	CACNA1A	19	13411423	Silent	SNP	C	TCGA-BB-7870-01A-11D-2229-08	2800781	13411423	45717560	63	6279											
ZNF569	148266	broad.mit.edu	37	chr19	37904957	37904957	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaattctcagatgtctgatGaggtccaaagtctgattgaa	12	13	10	6	0	3	6	1	5	3	1	5	6	4	6	1	1	0	0	1	1	3	2			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr19:37904957G>A	uc002ogi.2	-	6	1161	c.603C>T	c.(601-603)CTC>CTT	p.L201L	ZNF569_uc002ogh.2_Silent_p.L42L|ZNF569_uc002ogj.2_Silent_p.L225L	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	201	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GATGTCTGATGAGGTCCAAAG	0.358													7	6					0	0	0	0	A	37904957	A	A	37904957	2	1	33	1	0	0	0	0	0	0	0	1	18067	1277	45	2		2	ZNF569	19	37904957	Silent	SNP	G	TCGA-BB-7870-01A-11D-2229-08	24493534	37904957	21224026	64	6280											
PSG8	440533	broad.mit.edu	37	chr19	43268170	43268171	+	Missense_Mutation	DNP	GG	TT	TT																															gtcttcctgggtgacattctGgatcagcagggatgcattgg																										TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr19:43268170_43268171GG>TT	uc002ouo.2	-	2	425_426	c.327_328CC>AA	c.(325-330)ATCCAG>ATAAAG	p.Q110K	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Missense_Mutation_p.Q110K|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_5'UTR|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Missense_Mutation_p.Q110K|PSG8_uc002oum.3_Missense_Mutation_p.Q110K|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.Q110K	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	110	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				GTGACATTCTGGATCAGCAGGG	0.411													28	75					0	0	0	0	TT	43268171	TT	TT	43268170	3	4	33	1	0	0	0	0	1	0	0	0	12723	1357	47	4	989	4	PSG8	19	43268170	Missense_Mutation	DNP	GG	TCGA-BB-7870-01A-11D-2229-08	5363213	43268170	15860813	65	6281											
CPT1C	126129	broad.mit.edu	37	chr19	50216783	50216783	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcagagggtcagggaaggAgaactccaggcacaggtgtg	11	6	17	7	0	2	2	2	0	0	2	3	4	3	3	1	5	1	2	1	5	2	1			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr19:50216783A>T	uc002ppj.2	+	19	2538	c.2333A>T	c.(2332-2334)GAG>GTG	p.E778V	CPT1C_uc002ppk.2_Missense_Mutation_p.E767V|CPT1C_uc010eng.2_Missense_Mutation_p.E778V|CPT1C_uc010enh.2_Missense_Mutation_p.E778V|CPT1C_uc010eni.1_Missense_Mutation_p.E346V	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	778	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TCAGGGAAGGAGAACTCCAGG	0.607													18	17					0	0	0	0	T	50216783	T	T	50216783	3	4	33	1	0	0	0	0	1	0	0	0	3848	304	11	5	2403	5	CPT1C	19	50216783	Missense_Mutation	SNP	A	TCGA-BB-7870-01A-11D-2229-08	6948613	50216783	8912200	66	6282											
ZNF808	388558	broad.mit.edu	37	chr19	53058525	53058525	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tataccatcgtagacttcatActggagagaaatcttacaaa	16	11	6	8	1	2	2	1	0	1	2	3	4	2	3	1	1	3	1	1	1	7	6			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr19:53058525A>G	uc010epq.1	+	5	2533	c.2356A>G	c.(2356-2358)ACT>GCT	p.T786A	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	786					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TAGACTTCATACTGGAGAGAA	0.423													47	33					0	0	0	0	G	53058525	G	G	53058525	3	3	33	1	0	0	0	0	1	0	0	0	18240	391	14	5	2366	5	ZNF808	19	53058525	Missense_Mutation	SNP	A	TCGA-BB-7870-01A-11D-2229-08	2841742	53058525	6070458	67	6283											
AURKC	6795	broad.mit.edu	37	chr19	57744012	57744012	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctctacaaggagctgcaGaaaagcgagaaattagatga	17	6	12	6	1	1	4	0	1	1	3	1	7	1	5	0	1	5	3	0	1	6	2			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr19:57744012G>T	uc002qoe.2	+	4	588	c.399G>T	c.(397-399)CAG>CAT	p.Q133H	AURKC_uc002qoc.2_Missense_Mutation_p.Q114H|AURKC_uc002qod.2_Missense_Mutation_p.Q99H|AURKC_uc010etv.2_Missense_Mutation_p.Q130H	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	133	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		AGGAGCTGCAGAAAAGCGAGA	0.537													11	9					2.80697e-09	4.16368e-09	1	0	T	57744012	T	T	57744012	3	4	33	1	0	0	0	0	1	0	0	0	1226	933	33	2	418	2	AURKC	19	57744012	Missense_Mutation	SNP	G	TCGA-BB-7870-01A-11D-2229-08	4685487	57744012	1384971	68	6284											
SAMHD1	25939	broad.mit.edu	37	chr20	35526865	35526866	+	Missense_Mutation	DNP	GC	TT	TT																															ggtttttagtaatcctgattGctctgttgggggcagtctta																										TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr20:35526865_35526866GC>TT	uc002xgh.1	-	14	1715_1716	c.1585_1586GC>AA	c.(1585-1587)GCA>AAA	p.A529K	SAMHD1_uc010gft.1_Intron	NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	529					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				AATCCTGATTGCTCTGTTGGGG	0.322													7	13					0	0	0	0	TT	35526866	TT	TT	35526865	3	4	33	1	0	0	0	0	1	0	0	0	13893	1319	46	4	306	4	SAMHD1	20	35526865	Missense_Mutation	DNP	GC	TCGA-BB-7870-01A-11D-2229-08		35526865	27498655	69	6285											
PTGIS	5740	broad.mit.edu	37	chr20	48127716	48127716	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaatcggttgtatttaaataCctgaaataggaagaaggtcc	15	11	10	5	1	0	2	0	1	0	1	2	4	1	3	2	3	1	2	2	3	9	6			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr20:48127716C>T	uc002xut.2	-	9	1261	c.1207G>A	c.(1207-1209)GTA>ATA	p.V403I	PTGIS_uc010zyi.1_Missense_Mutation_p.V264I	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	403					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	TATTTAAATACCTGAAATAGG	0.343													3	4					0	0	0	0	T	48127716	T	T	48127716	3	4	33	1	0	0	0	0	1	0	0	0	12815	521	18	4	303	4	PTGIS	20	48127716	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08	12600851	48127716	14897804	70	6286											
EP300	2033	broad.mit.edu	37	chr22	41566476	41566478	+	In_Frame_Del	DEL	TCC	-	-																															gattatatcttccattgccaTcctcctgaccagaagatacc																										TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chr22:41566476_41566478delTCC	uc003azl.3	+	27	4748_4750	c.4353_4355delTCC	c.(4351-4356)CATCCT>CAT	p.P1453del		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1453					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.P1452L(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TCCATTGCCATCCTCCTGACCAG	0.429			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				---	---	---								-	41566478	-	-	41566476	7	5	33	1	0	1	0	1	0	0	0	0	5172	1432	50	0	4459	0	EP300	22	41566476	In_Frame_Del	DEL	TCC	TCGA-BB-7870-01A-11D-2229-08		41566476	9738090	71	6287											
ARX	170302	broad.mit.edu	37	chrX	25028384	25028384	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttgtgcagctcacctggactCgggcctcggtcaagtccagc	6	9	12	14	2	2	0	2	0	0	0	5	1	3	1	3	3	3	2	3	3	1	1			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chrX:25028384C>G	uc004dbp.3	-	3	1323	c.1112G>C	c.(1111-1113)CGA>CCA	p.R371P		NM_139058	NP_620689	Q96QS3	ARX_HUMAN	aristaless related homeobox	371	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CACCTGGACTCGGGCCTCGGT	0.632													4	1					0	0	0	0	G	25028384	G	G	25028384	3	3	33	1	0	0	0	0	1	0	0	0	1006	884	31	3	588	3	ARX	23	25028384	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08		25028384	130242176	72	6288											
FAM47C	442444	broad.mit.edu	37	chrX	37027442	37027442	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcgtatctcatctccgccCagagccttctgagactggag	8	9	10	14	3	3	2	1	1	3	2	5	4	3	3	3	1	1	1	3	1	1	2			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chrX:37027442C>T	uc004ddl.1	+	1	973	c.959C>T	c.(958-960)CCA>CTA	p.P320L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	320										ovary(3)	3						CATCTCCGCCCAGAGCCTTCT	0.602													6	6					0	0	0	0	T	37027442	T	T	37027442	3	4	33	1	0	0	0	0	1	0	0	0	5603	594	21	4	961	4	FAM47C	23	37027442	Missense_Mutation	SNP	C	TCGA-BB-7870-01A-11D-2229-08	11999058	37027442	118243118	73	6289											
PRRG1	5638	broad.mit.edu	37	chrX	37265460	37265460	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatgtgctctgttttgtacAgggaatcatcatccagggac	9	13	11	8	0	3	0	2	0	1	0	4	2	4	2	1	2	2	4	1	2	3	4			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chrX:37265460A>C	uc004ddn.2	+	3	213	c.-40_splice	c.e3-2		PRRG1_uc004ddo.2_Splice_Site|PRRG1_uc010ngx.1_Splice_Site	NM_000950	NP_000941	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1							extracellular region|integral to plasma membrane	calcium ion binding			ovary(1)|breast(1)	2						TGTTTTGTACAGGGAATCATC	0.438													4	7					0	0	0	0	C	37265460	C	C	37265460	5	2	33	1	0	0	0	0	0	0	1	0	12667	202	7	5		5	PRRG1	23	37265460	Splice_Site	SNP	A	TCGA-BB-7870-01A-11D-2229-08	238018	37265460	118005100	74	6290											
ODZ1	10178	broad.mit.edu	37	chrX	123518698	123518698	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaaaatctggcgtccaataAgaggtcctgcaggaaccaaa	15	7	10	9	1	1	2	0	1	1	1	3	3	3	3	3	3	2	1	3	3	6	1			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chrX:123518698A>T	uc004euj.2	-	29	6126	c.6062T>A	c.(6061-6063)CTT>CAT	p.L2021H	ODZ1_uc011muj.1_Missense_Mutation_p.L2027H|ODZ1_uc010nqy.2_Missense_Mutation_p.L2028H	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2021	YD 14.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GCGTCCAATAAGAGGTCCTGC	0.423													4	1					0	0	0	0	T	123518698	T	T	123518698	3	4	33	1	0	0	0	0	1	0	0	0	10888	72	3	5	2127	5	ODZ1	23	123518698	Missense_Mutation	SNP	A	TCGA-BB-7870-01A-11D-2229-08	86253238	123518698	31751862	75	6291											
MAGEC3	139081	broad.mit.edu	37	chrX	140985531	140985531	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaagatatggaagacagagcCcaggccataattgacaccac	17	5	9	10	0	0	4	0	1	0	3	0	5	0	5	3	2	1	0	3	2	4	3			TCGA-BB-7870-01A-11D-2229-08	TCGA-BB-7870-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	d584f4ec-09b0-40fe-bba2-256b6cf6974e	201d93ee-887a-4fed-aa95-87ce043c8988	g.chrX:140985531C>A	uc011mwp.1	+	8	1845	c.1845C>A	c.(1843-1845)GCC>GCA	p.A615A	MAGEC3_uc004fbs.2_3'UTR|MAGEC3_uc010nsj.2_3'UTR	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	615	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAGACAGAGCCCAGGCCATAA	0.473													5	9					3.59834e-05	4.64133e-05	1	0	A	140985531	A	A	140985531	2	1	33	1	0	0	0	0	0	0	0	1	9235	610	22	4		4	MAGEC3	23	140985531	Silent	SNP	C	TCGA-BB-7870-01A-11D-2229-08	17466833	140985531	14285029	76	6292											
SAMD11	148398	broad.mit.edu	37	chr1	878709	878709	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaagtggaccgtggatgaCgtctgcagcttcgtgggggg	7	8	17	9	3	1	1	0	1	1	0	2	3	1	3	2	5	2	2	2	5	1	1	rs144453653	byFrequency	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:878709C>T	uc001abw.1	+	12	1721	c.1641C>T	c.(1639-1641)GAC>GAT	p.D547D	SAMD11_uc001abx.1_Silent_p.D410D	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	547	SAM.					nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CCGTGGATGACGTCTGCAGCT	0.667													6	26					0	0	0	0	T	878709	T	T	878709	2	4	34	1	0	0	0	0	0	0	0	1	13881	535	19	1		1	SAMD11	1	878709	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08		878709	248371912	1	6293											
AJAP1	55966	broad.mit.edu	37	chr1	4772664	4772664	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccttggatccccggagaaGgatcccaggtggggttagca	8	8	15	10	1	0	1	0	0	0	1	3	4	3	3	4	6	1	2	4	6	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:4772664G>T	uc001alm.1	+	2	1115	c.734G>T	c.(733-735)AGG>ATG	p.R245M	AJAP1_uc001aln.2_Missense_Mutation_p.R245M	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	245	Extracellular (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CCCCGGAGAAGGATCCCAGGT	0.498													24	48					9.86323e-18	1.2329e-17	1	0	T	4772664	T	T	4772664	3	4	34	1	0	0	0	0	1	0	0	0	438	1000	35	4	740	4	AJAP1	1	4772664	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	3893955	4772664	244477957	2	6294											
CHD5	26038	broad.mit.edu	37	chr1	6196851	6196851	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcaggcccactcgatggaGcccaggatggcctggtcaat	9	6	14	12	1	1	0	1	0	0	0	2	3	1	2	3	6	1	1	3	6	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:6196851G>A	uc001amb.1	-	16	2611	c.2511C>T	c.(2509-2511)GGC>GGT	p.G837G	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	837	Helicase ATP-binding.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		ACTCGATGGAGCCCAGGATGG	0.587													20	29					0	0	0	0	A	6196851	A	A	6196851	2	1	34	1	0	0	0	0	0	0	0	1	3343	958	34	4		4	CHD5	1	6196851	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1424187	6196851	243053770	3	6295											
RERE	473	broad.mit.edu	37	chr1	8418541	8418541	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcggggggatggtgagggCgctgtgccgggcaaagtgct	5	7	22	7	3	0	1	0	1	0	0	1	2	0	2	1	7	2	3	1	7	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:8418541C>T	uc001ape.2	-	21	4864	c.4054G>A	c.(4054-4056)GCC>ACC	p.A1352T	RERE_uc001apf.2_Missense_Mutation_p.A1352T|RERE_uc001apd.2_Missense_Mutation_p.A798T	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1352					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		ATGGTGAGGGCGCTGTGCCGG	0.701													5	12					0	0	0	0	T	8418541	T	T	8418541	3	4	34	1	0	0	0	0	1	0	0	0	13296	768	27	1	662	1	RERE	1	8418541	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2221690	8418541	240832080	4	6296											
PTCHD2	57540	broad.mit.edu	37	chr1	11579548	11579548	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acatccccttgctggaggtcGaggaagagccaggtgagagc	10	6	15	10	1	0	2	0	1	0	2	2	6	1	4	3	4	3	1	3	4	1	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:11579548G>A	uc001ash.3	+	8	2164	c.2026G>A	c.(2026-2028)GAG>AAG	p.E676K	PTCHD2_uc001asi.1_Missense_Mutation_p.E676K	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	676	Cytoplasmic (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GCTGGAGGTCGAGGAAGAGCC	0.632													60	177					0	0	0	0	A	11579548	A	A	11579548	3	1	34	1	0	0	0	0	1	0	0	0	12795	1059	37	1	2052	1	PTCHD2	1	11579548	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	3161007	11579548	237671073	5	6297											
LOC649330	649330	broad.mit.edu	37	chr1	12907549	12907549	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaattttttccaggttttcCaggagagaatccactttctg	9	16	7	9	0	2	1	1	0	1	1	5	3	5	2	3	2	0	1	3	2	2	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:12907549C>A	uc009vno.2	-	1	689	c.594G>T	c.(592-594)CTG>CTT	p.L198L	HNRNPCL1_uc010obf.1_Silent_p.L198L	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	198							nucleic acid binding|nucleotide binding				0						CCAGGTTTTCCAGGAGAGAAT	0.438													39	52					1.78197e-24	2.3663e-24	1	0	A	12907549	A	A	12907549	2	1	34	1	0	0	0	0	0	0	0	1	8935	581	21	4		4	LOC649330	1	12907549	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1328001	12907549	236343072	6	6298											
FUCA1	2517	broad.mit.edu	37	chr1	24180881	24180881	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagattcttctgtaacatcaGacaatgccatgtcacgacga	13	10	7	11	2	4	2	2	0	2	2	4	4	4	2	1	0	2	1	1	0	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:24180881G>C	uc001bie.2	-	5	983	c.938C>G	c.(937-939)TCT>TGT	p.S313C	FUCA1_uc009vqt.1_RNA	NM_000147	NP_000138	P04066	FUCO_HUMAN	fucosidase, alpha-L-1, tissue precursor	313					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		TGTAACATCAGACAATGCCAT	0.343													46	85					0	0	0	0	C	24180881	C	C	24180881	3	2	34	1	0	0	0	0	1	0	0	0	6128	942	33	2	478	2	FUCA1	1	24180881	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	11273332	24180881	225069740	7	6299											
MYOM3	127294	broad.mit.edu	37	chr1	24397718	24397718	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctcgctccaggatgtcaatGttccagccggagatcagttt	8	11	10	12	2	2	1	2	0	0	1	5	3	4	2	4	2	1	3	4	2	1	2	rs114185181	by1000genomes	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:24397718G>A	uc001bin.3	-	25	3202	c.3039C>T	c.(3037-3039)AAC>AAT	p.N1013N	MYOM3_uc001bim.3_Silent_p.N670N|MYOM3_uc001bio.2_Silent_p.N1013N	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1013										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GGATGTCAATGTTCCAGCCGG	0.562											OREG0013235	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	20					0	0	0	0	A	24397718	A	A	24397718	2	1	34	1	0	0	0	0	0	0	0	1	10146	1368	48	4		4	MYOM3	1	24397718	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	216837	24397718	224852903	8	6300											
C1orf63	57035	broad.mit.edu	37	chr1	25571721	25571722	+	Missense_Mutation	DNP	GC	TT	TT																															aacagttctgagactagctgGcaagtcaatgttggttgttc																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:25571721_25571722GC>TT	uc001bjw.2	-	3	843_844	c.591_592GC>AA	c.(589-594)TTGCCA>TTAACA	p.P198T		NM_020317	NP_064713	Q9BUV0	CA063_HUMAN	hypothetical protein LOC57035	198										pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.9e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000333)|BRCA - Breast invasive adenocarcinoma(304;0.000443)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000932)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AGACTAGCTGGCAAGTCAATGT	0.386													37	50					0	0	0	0	TT	25571722	TT	TT	25571721	3	4	34	1	0	0	0	0	1	0	0	0	2063	1203	42	4	292	4	C1orf63	1	25571721	Missense_Mutation	DNP	GC	TCGA-BB-7871-01A-11D-2229-08	1174003	25571721	223678900	9	6301											
AIM1L	55057	broad.mit.edu	37	chr1	26671807	26671807	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggacattttcagagttctGaacaaacttattccttgggg	11	13	10	7	0	2	2	1	1	1	1	3	3	3	3	1	3	2	1	1	3	3	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:26671807G>A	uc001bmd.3	-						uc009vsi.1_Nonsense_Mutation_p.Q448*	NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like								sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		TCAGAGTTCTGAACAAACTTA	0.572													22	47					0	0	0	0	A	26671807	A	A	26671807	1	1	34	0	1	0	0	0	0	0	0	0	431	1305	45	2		2	AIM1L	1	26671807	5'Flank	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1100086	26671807	222578814	10	6302											
THRAP3	9967	broad.mit.edu	37	chr1	36752628	36752628	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgaggcggcggtcaccccGtcctagccccgtgccaaaac	7	5	13	16	4	1	1	1	1	0	0	2	1	2	1	6	4	3	0	6	4	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:36752628G>T	uc001cae.3	+	4	1021	c.797G>T	c.(796-798)CGT>CTT	p.R266L	THRAP3_uc001caf.3_Missense_Mutation_p.R266L|THRAP3_uc001cag.1_Missense_Mutation_p.R266L	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	266	Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CGGTCACCCCGTCCTAGCCCC	0.617			T	USP6	aneurysmal bone cysts								31	137					1.45844e-13	1.73455e-13	1	0	T	36752628	T	T	36752628	3	4	34	1	0	0	0	0	1	0	0	0	15940	1145	40	3	803	3	THRAP3	1	36752628	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	10080821	36752628	212497993	11	6303											
EPHA10	284656	broad.mit.edu	37	chr1	38227327	38227327	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagacgcgcaccgagacaagCgccacgcatgcgcccacgtc	10	3	11	17	7	0	2	0	0	0	2	1	3	0	2	3	0	2	2	3	0	2	1	rs143310845		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:38227327C>T	uc009vvi.2	-	3	686	c.600G>A	c.(598-600)GCG>GCA	p.A200A	EPHA10_uc001cbw.3_Silent_p.A200A	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	200	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCGAGACAAGCGCCACGCATG	0.672													26	64					0	0	0	0	T	38227327	T	T	38227327	2	4	34	1	0	0	0	0	0	0	0	1	5190	755	27	1		1	EPHA10	1	38227327	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1474699	38227327	211023294	12	6304											
AKIRIN1	79647	broad.mit.edu	37	chr1	39463964	39463964	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacctcactcctcagcactCacagcacctagctctccagg	10	7	5	19	0	4	0	3	0	1	0	6	0	5	0	4	1	4	3	4	1	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:39463964C>G	uc001ccw.2	+	2	479	c.342C>G	c.(340-342)CTC>CTG	p.L114L	AKIRIN1_uc010oip.1_Silent_p.L114L|AKIRIN1_uc010oiq.1_Intron	NM_024595	NP_078871	Q9H9L7	AKIR1_HUMAN	akirin 1 isoform 1	114						nucleus					0						CCTCAGCACTCACAGCACCTA	0.408													12	41					0	0	0	0	G	39463964	G	G	39463964	2	3	34	1	0	0	0	0	0	0	0	1	461	813	29	2		2	AKIRIN1	1	39463964	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1236637	39463964	209786657	13	6305											
MACF1	23499	broad.mit.edu	37	chr1	39901344	39901344	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatggtggaagaaaaatacCagaaagcagaaaacatgtat	22	6	9	4	0	0	3	0	0	0	3	0	4	0	4	1	2	3	2	1	2	9	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:39901344C>G	uc010oiu.1	+	34	13350	c.13219C>G	c.(13219-13221)CAG>GAG	p.Q4407E	MACF1_uc010ois.1_Missense_Mutation_p.Q3905E|MACF1_uc001cda.1_Missense_Mutation_p.Q3792E|MACF1_uc001cdc.1_Missense_Mutation_p.Q2862E	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAAAAATACCAGAAAGCAGA	0.463													25	87					0	0	0	0	G	39901344	G	G	39901344	3	3	34	1	0	0	0	0	1	0	0	0	9195	595	21	4	18122	4	MACF1	1	39901344	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	437380	39901344	209349277	14	6306											
NASP	4678	broad.mit.edu	37	chr1	46067982	46067982	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtttaggacagaaacatctgGtgatgggggatattccagca	12	10	13	6	0	1	2	0	1	1	1	2	4	2	4	1	4	2	2	1	4	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:46067982G>C	uc001coi.1	+	3	265	c.163G>C	c.(163-165)GTG>CTG	p.V55L	NASP_uc010olq.1_Intron|NASP_uc001coh.1_Missense_Mutation_p.V57L|NASP_uc001coj.1_Missense_Mutation_p.V55L|NASP_uc010olr.1_Intron|NASP_uc001cok.1_5'UTR	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	55	TPR 1.				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					GAAACATCTGGTGATGGGGGA	0.348													31	77					0	0	0	0	C	46067982	C	C	46067982	3	2	34	1	0	0	0	0	1	0	0	0	10225	1261	44	4	250	4	NASP	1	46067982	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	6166638	46067982	203182639	15	6307											
GPBP1L1	60313	broad.mit.edu	37	chr1	46124746	46124746	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagccaagcaggaacaaaaTcatgctgcgccatttaggtc	13	9	9	10	1	1	0	1	0	0	0	2	1	1	1	2	2	5	2	2	2	6	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:46124746T>C	uc001coq.2	-	4	1375	c.14A>G	c.(13-15)GAT>GGT	p.D5G		NM_021639	NP_067652	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AGGAACAAAATCATGCTGCGC	0.433													30	85					0	0	0	0	C	46124746	C	C	46124746	3	2	34	1	0	0	0	0	1	0	0	0	6634	1435	50	5	1450	5	GPBP1L1	1	46124746	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	56764	46124746	203125875	16	6308											
PIK3R3	8503	broad.mit.edu	37	chr1	46546392	46546392	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccatttggaactgctgaaGtcattggcttaggtggcttt	7	16	11	7	0	1	1	1	1	0	0	2	2	2	2	1	4	2	3	1	4	3	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:46546392G>A	uc001cpb.3	-	2	893	c.137C>T	c.(136-138)ACT>ATT	p.T46I	PIK3R3_uc009vyb.2_Missense_Mutation_p.T46I|PIK3R3_uc009vyc.2_Missense_Mutation_p.T63I|PIK3R3_uc001cpc.3_Missense_Mutation_p.T46I|PIK3R3_uc010olw.1_Missense_Mutation_p.T92I	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	46					insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					AACTGCTGAAGTCATTGGCTT	0.393													96	276					0	0	0	0	A	46546392	A	A	46546392	3	1	34	1	0	0	0	0	1	0	0	0	11975	1029	36	4	1284	4	PIK3R3	1	46546392	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	421646	46546392	202704229	17	6309											
CC2D1B	200014	broad.mit.edu	37	chr1	52825164	52825164	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcatggcactcagatccaCgggctgccccttctccaggg	6	7	13	15	1	2	1	1	0	1	1	4	1	3	1	4	4	1	3	4	4	0	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:52825164C>A	uc001ctq.1	-	9	1123	c.985G>T	c.(985-987)GTG>TTG	p.V329L	CC2D1B_uc001ctr.2_5'Flank|CC2D1B_uc001cts.2_Missense_Mutation_p.V20L	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	329										ovary(2)	2						CTCAGATCCACGGGCTGCCCC	0.637													19	62					1.87028e-06	1.9966e-06	1	0	A	52825164	A	A	52825164	3	1	34	1	0	0	0	0	1	0	0	0	2739	536	19	3	1655	3	CC2D1B	1	52825164	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	6278772	52825164	196425457	18	6310											
SLC1A7	6512	broad.mit.edu	37	chr1	53555531	53555531	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgggcagtcccacggaggtGagcacgatgaccatggtgac	9	6	16	10	2	0	3	0	3	0	0	1	5	1	4	2	4	1	2	2	4	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:53555531G>A	uc001cuy.2	-	9	1470	c.1302C>T	c.(1300-1302)CTC>CTT	p.L434L	SLC1A7_uc001cux.2_Silent_p.L87L	NM_006671	NP_006662	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter),	434	Helical; (Potential).					integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|large_intestine(1)	3				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	CCACGGAGGTGAGCACGATGA	0.627													34	111					0	0	0	0	A	53555531	A	A	53555531	2	1	34	1	0	0	0	0	0	0	0	1	14502	1277	45	2		2	SLC1A7	1	53555531	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	730367	53555531	195695090	19	6311											
WDR78	79819	broad.mit.edu	37	chr1	67337096	67337096	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacattgaacatctttattCtttggtgctccattgaaagt	10	17	6	8	0	3	2	1	2	2	0	4	2	4	2	1	1	2	1	1	1	3	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:67337096C>G	uc001dcx.2	-	6	953	c.897G>C	c.(895-897)AAG>AAC	p.K299N	WDR78_uc001dcy.2_Missense_Mutation_p.K299N|WDR78_uc001dcz.2_Missense_Mutation_p.K299N|WDR78_uc009waw.2_Missense_Mutation_p.K45N|WDR78_uc009wax.2_RNA	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	299										ovary(2)	2						CATCTTTATTCTTTGGTGCTC	0.303													17	49					0	0	0	0	G	67337096	G	G	67337096	3	3	34	1	0	0	0	0	1	0	0	0	17396	912	32	2	1754	2	WDR78	1	67337096	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	13781565	67337096	181913525	20	6312											
NEGR1	257194	broad.mit.edu	37	chr1	71873200	71873200	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaacacaaggtaccagcAggagaaaagaacatcagcgc	17	4	10	10	1	2	2	2	0	0	2	2	3	2	2	1	2	5	2	1	2	6	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:71873200A>T	uc001dfw.2	-	7	1094	c.994T>A	c.(994-996)TGC>AGC	p.C332S	NEGR1_uc001dfv.2_Missense_Mutation_p.C204S|NEGR1_uc010oqs.1_Missense_Mutation_p.C288S	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	332					cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		AGGTACCAGCAGGAGAAAAGA	0.398													15	38					0	0	0	0	T	71873200	T	T	71873200	3	4	34	1	0	0	0	0	1	0	0	0	10371	188	7	5	74	5	NEGR1	1	71873200	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	4536104	71873200	177377421	21	6313											
C1orf173	127254	broad.mit.edu	37	chr1	75038328	75038328	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatcttccttgcaaaggaaGgcttcctttgcaaggcttcc	9	12	8	12	0	1	0	0	0	1	0	4	1	4	1	3	3	2	4	3	3	3	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:75038328G>C	uc001dgg.2	-	14	3285	c.3066C>G	c.(3064-3066)GCC>GCG	p.A1022A		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1022	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TGCAAAGGAAGGCTTCCTTTG	0.502													33	98					0	0	0	0	C	75038328	C	C	75038328	2	2	34	1	0	0	0	0	0	0	0	1	2023	987	35	4		4	C1orf173	1	75038328	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	3165128	75038328	174212293	22	6314											
SYDE2	84144	broad.mit.edu	37	chr1	85656331	85656331	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaattgcgtttctttgaaaCagtgatgctgttaagtggct	9	15	10	7	1	1	2	0	2	1	0	1	2	1	2	1	1	3	4	1	1	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:85656331C>A	uc009wcm.2	-	2	899	c.850G>T	c.(850-852)GTT>TTT	p.V284F	SYDE2_uc001dku.3_Missense_Mutation_p.V284F	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	284					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		TTCTTTGAAACAGTGATGCTG	0.373													40	104					4.67007e-22	6.10222e-22	1	0	A	85656331	A	A	85656331	3	1	34	1	0	0	0	0	1	0	0	0	15502	478	17	4	2758	4	SYDE2	1	85656331	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	10618003	85656331	163594290	23	6315											
SNX7	51375	broad.mit.edu	37	chr1	99150522	99150522	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgataaaccaaatcaagtttGaggatgaaccagatttaaag	18	10	8	5	0	1	4	1	3	0	1	1	5	1	5	2	1	2	1	2	1	7	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:99150522G>A	uc010ouc.1	+	2	314	c.262G>A	c.(262-264)GAG>AAG	p.E88K	SNX7_uc001dsa.2_Missense_Mutation_p.E24K|SNX7_uc010oud.1_Missense_Mutation_p.E88K	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	24					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		AATCAAGTTTGAGGATGAACC	0.348													18	64					0	0	0	0	A	99150522	A	A	99150522	3	1	34	1	0	0	0	0	1	0	0	0	14971	1291	45	2	268	2	SNX7	1	99150522	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	13494191	99150522	150100099	24	6316											
AMPD2	271	broad.mit.edu	37	chr1	110171292	110171292	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcagacctggaggagagcAaataccagaatgcagagctg	14	6	13	8	0	1	4	1	0	0	4	1	6	1	5	2	2	4	3	2	2	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:110171292A>G	uc009wfh.1	+	13	2139	c.1597A>G	c.(1597-1599)AAA>GAA	p.K533E	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Missense_Mutation_p.K452E|AMPD2_uc001dyc.1_Missense_Mutation_p.K533E|AMPD2_uc010ovr.1_Missense_Mutation_p.K458E|AMPD2_uc001dyd.1_Missense_Mutation_p.K414E|AMPD2_uc001dye.1_5'Flank	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	533					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		GGAGGAGAGCAAATACCAGAA	0.597													10	36					0	0	0	0	G	110171292	G	G	110171292	3	3	34	1	0	0	0	0	1	0	0	0	586	131	5	5	1684	5	AMPD2	1	110171292	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	11020770	110171292	139079329	25	6317											
KCNA3	3738	broad.mit.edu	37	chr1	111215826	111215826	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaaagcgctatggttcatacCcccctcttcgatcaccatat	10	11	6	14	2	3	0	2	0	1	0	4	2	3	0	4	1	2	2	4	1	4	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:111215826C>G	uc001dzv.1	-	1	1830	c.1606G>C	c.(1606-1608)GGT>CGT	p.G536R		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	536						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGTTCATACCCCCCTCTTCG	0.517													21	99					0	0	0	0	G	111215826	G	G	111215826	3	3	34	1	0	0	0	0	1	0	0	0	8043	623	22	4	125	4	KCNA3	1	111215826	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1044534	111215826	138034795	26	6318											
CHD1L	9557	broad.mit.edu	37	chr1	146758169	146758169	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggatgctctcattgtgcActgcgtaggtacgagaagtg	9	10	14	8	3	1	1	1	0	1	1	2	4	1	2	0	2	4	4	0	2	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:146758169A>G	uc001epm.3	+	18	2276	c.2213A>G	c.(2212-2214)CAC>CGC	p.H738R	uc001epp.2_Intron|CHD1L_uc001epn.3_Missense_Mutation_p.H625R|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Missense_Mutation_p.H644R|CHD1L_uc010ozp.1_Missense_Mutation_p.H457R|CHD1L_uc001epo.3_Missense_Mutation_p.H534R|CHD1L_uc009wji.2_Missense_Mutation_p.H457R	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	738	Macro.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					CTCATTGTGCACTGCGTAGGT	0.587													34	170					0	0	0	0	G	146758169	G	G	146758169	3	3	34	1	0	0	0	0	1	0	0	0	3339	159	6	5	2283	5	CHD1L	1	146758169	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	35542343	146758169	102492452	27	6319											
GJA8	2703	broad.mit.edu	37	chr1	147380514	147380514	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actaagaagttccggctggaGgggaccctgctgaggaccta	10	7	14	10	1	0	2	0	1	0	1	1	5	1	5	3	5	1	3	3	5	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:147380514G>T	uc001epu.1	+	2	495	c.432G>T	c.(430-432)GAG>GAT	p.E144D		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	144	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					TCCGGCTGGAGGGGACCCTGC	0.617													23	122					1.77063e-15	2.17446e-15	1	0	T	147380514	T	T	147380514	3	4	34	1	0	0	0	0	1	0	0	0	6442	991	35	4	434	4	GJA8	1	147380514	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	622345	147380514	101870107	28	6320											
GBA	2629	broad.mit.edu	37	chr1	155207167	155207167	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcagcagcaagcgttggtCatccagcatgagtaggcgga	10	6	16	9	2	1	1	1	1	0	0	2	2	2	2	1	4	4	6	1	4	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:155207167C>T	uc001fjh.2	-	7	1114	c.964G>A	c.(964-966)GAC>AAC	p.D322N	RAG1AP1_uc010pey.1_Intron|GBA_uc010pfw.1_Missense_Mutation_p.D209N|GBA_uc010pfx.1_Missense_Mutation_p.D273N|GBA_uc001fji.2_Missense_Mutation_p.D322N|GBA_uc001fjj.2_Missense_Mutation_p.D322N|GBA_uc001fjk.2_Missense_Mutation_p.D322N|GBA_uc001fjl.2_Missense_Mutation_p.D322N|GBA_uc010pfy.1_Missense_Mutation_p.D235N|GBA_uc009wqk.1_Missense_Mutation_p.D235N	NM_000157	NP_000148	P04062	GLCM_HUMAN	glucocerebrosidase precursor	322					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			ovary(1)|skin(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	AAGCGTTGGTCATCCAGCATG	0.572									Gaucher_disease_type_I				19	85					0	0	0	0	T	155207167	T	T	155207167	3	4	34	1	0	0	0	0	1	0	0	0	6301	826	29	2	666	2	GBA	1	155207167	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	7826653	155207167	94043454	29	6321											
ARHGEF11	9826	broad.mit.edu	37	chr1	156931516	156931516	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgtctttccccaagcttcGggaatccttggggcttgcct	5	13	11	12	1	1	0	0	0	1	0	4	2	3	1	4	3	2	2	4	3	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:156931516G>C	uc001fqo.2	-	13	2112	c.1072C>G	c.(1072-1074)CGA>GGA	p.R358G	ARHGEF11_uc001fqn.2_Missense_Mutation_p.R398G	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	358	RGSL.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCCAAGCTTCGGGAATCCTTG	0.368													15	74					0	0	0	0	C	156931516	C	C	156931516	3	2	34	1	0	0	0	0	1	0	0	0	896	1124	39	3	3608	3	ARHGEF11	1	156931516	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1724349	156931516	92319105	30	6322											
FCRL5	83416	broad.mit.edu	37	chr1	157491038	157491038	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggtcccccaccgcagcatGggtcccgggagccctgaggg	6	4	15	16	2	0	1	0	1	0	0	2	2	2	2	5	4	2	2	5	4	0	0	rs142243479		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:157491038G>T	uc001fqu.2	-	11	2442	c.2284C>A	c.(2284-2286)CAT>AAT	p.H762N	FCRL5_uc009wsm.2_Missense_Mutation_p.H762N	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	762	Extracellular (Potential).|Ig-like C2-type 8.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				ACCGCAGCATGGGTCCCGGGA	0.537													12	49					1.5842e-08	1.74833e-08	1	0	T	157491038	T	T	157491038	3	4	34	1	0	0	0	0	1	0	0	0	5830	1348	47	4	677	4	FCRL5	1	157491038	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	559522	157491038	91759583	31	6323											
SPTA1	6708	broad.mit.edu	37	chr1	158582684	158582684	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attctctatttcatcactggActtgatgttttctgactcct	7	19	5	10	0	4	2	2	2	2	0	6	3	5	3	1	1	0	1	1	1	1	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:158582684A>T	uc001fst.1	-	51	7256	c.7057T>A	c.(7057-7059)TCC>ACC	p.S2353T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2353	EF-hand 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCATCACTGGACTTGATGTTT	0.478													42	56					0	0	0	0	T	158582684	T	T	158582684	3	4	34	1	0	0	0	0	1	0	0	0	15182	275	10	5	210	5	SPTA1	1	158582684	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	1091646	158582684	90667937	32	6324											
AIM2	9447	broad.mit.edu	37	chr1	159038376	159038376	+	Frame_Shift_Del	DEL	T	-	-																															accttaacatgaggagagacTtttggtgcagcacgttgctt																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:159038376delT	uc001ftj.1	-	3	623	c.378delA	c.(376-378)AAAfs	p.K126fs		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	126					cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					GAGGAGAGACTTTTGGTGCAG	0.448													---	---	---								-	159038376	-	-	159038376	7	5	34	1	0	1	0	1	0	0	0	0	432	1606	56	0	669	0	AIM2	1	159038376	Frame_Shift_Del	DEL	T	TCGA-BB-7871-01A-11D-2229-08	455692	159038376	90212245	33	6325											
OR10J1	26476	broad.mit.edu	37	chr1	159410206	159410206	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtgtgctggtgcttgttgtaCctatgggtctggttttcatt	3	19	13	6	0	2	0	1	0	1	0	2	0	2	0	1	3	3	5	1	3	2	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:159410206C>A	uc010piv.1	+	1	658	c.658C>A	c.(658-660)CCT>ACT	p.P220T	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	220	Helical; Name=5; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					GCTTGTTGTACCTATGGGTCT	0.453													62	99					5.86059e-21	7.55707e-21	1	0	A	159410206	A	A	159410206	3	1	34	1	0	0	0	0	1	0	0	0	10964	507	18	4	660	4	OR10J1	1	159410206	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	371830	159410206	89840415	34	6326											
APOA2	336	broad.mit.edu	37	chr1	161192214	161192214	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcactgggtggcaggctgtGttccaagttccacgaaatag	9	11	12	9	1	1	0	1	0	0	0	3	1	3	0	2	3	0	4	2	3	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:161192214G>T	uc001fzc.1	-	4	342	c.284C>A	c.(283-285)ACA>AAA	p.T95K	APOA2_uc001fzb.1_RNA	NM_001643	NP_001634	P02652	APOA2_HUMAN	apolipoprotein A-II preproprotein	95					cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GGCAGGCTGTGTTCCAAGTTC	0.522													47	243					1.89013e-27	2.55846e-27	1	0	T	161192214	T	T	161192214	3	4	34	1	0	0	0	0	1	0	0	0	782	1377	48	4	22	4	APOA2	1	161192214	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1782008	161192214	88058407	35	6327											
NOS1AP	9722	broad.mit.edu	37	chr1	162337111	162337111	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagctcatcaagttccgaGagtcaggcatcgcctcggag	9	8	13	11	3	3	1	3	0	0	1	6	4	4	3	2	3	1	3	2	3	1	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:162337111G>T	uc001gbv.2	+	10	1762	c.1375G>T	c.(1375-1377)GAG>TAG	p.E459*	NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Nonsense_Mutation_p.E454*|NOS1AP_uc009wut.1_Nonsense_Mutation_p.E164*	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	459					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			CAAGTTCCGAGAGTCAGGCAT	0.662													10	39					2.68362e-12	3.13089e-12	1	0	T	162337111	T	T	162337111	4	4	34	1	0	0	0	0	0	1	0	0	10596	943	33	2	1467	2	NOS1AP	1	162337111	Nonsense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1144897	162337111	86913510	36	6328											
FAM5B	57795	broad.mit.edu	37	chr1	177247744	177247744	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcccgatgaccggttccTgaactccacagctatctccc	7	9	8	17	2	1	2	0	2	1	0	4	3	3	2	5	1	3	3	5	1	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:177247744T>A	uc001glf.2	+	7	1370	c.1058T>A	c.(1057-1059)CTG>CAG	p.L353Q	FAM5B_uc010pna.1_Missense_Mutation_p.L103Q|FAM5B_uc001glg.2_Missense_Mutation_p.L248Q	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	353						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GACCGGTTCCTGAACTCCACA	0.557													65	360					0	0	0	0	A	177247744	A	A	177247744	3	1	34	1	0	0	0	0	1	0	0	0	5625	1580	55	5	1080	5	FAM5B	1	177247744	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	14910633	177247744	72002877	37	6329											
ABL2	27	broad.mit.edu	37	chr1	179100584	179100584	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcatttagtgcctggggttCaacatcacaaccatagggac	11	10	9	11	0	3	0	3	0	0	0	3	1	3	1	2	3	3	1	2	3	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:179100584C>G	uc001gmj.3	-	3	540	c.253G>C	c.(253-255)GAA>CAA	p.E85Q	ABL2_uc010pnf.1_Missense_Mutation_p.E85Q|ABL2_uc010png.1_Missense_Mutation_p.E64Q|ABL2_uc010pnh.1_Missense_Mutation_p.E64Q|ABL2_uc009wxe.2_Missense_Mutation_p.E64Q|ABL2_uc001gmg.3_Missense_Mutation_p.E70Q|ABL2_uc001gmi.3_Missense_Mutation_p.E70Q|ABL2_uc001gmh.3_Missense_Mutation_p.E49Q|ABL2_uc010pne.1_Missense_Mutation_p.E49Q|ABL2_uc009wxf.1_Missense_Mutation_p.E70Q|ABL2_uc001gmk.2_Missense_Mutation_p.E49Q	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	85	CAP.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GCCTGGGGTTCAACATCACAA	0.448			T	ETV6	AML								17	55					0	0	0	0	G	179100584	G	G	179100584	3	3	34	1	0	0	0	0	1	0	0	0	93	835	29	2	3380	2	ABL2	1	179100584	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1852840	179100584	70150037	38	6330											
CEP350	9857	broad.mit.edu	37	chr1	180065045	180065045	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtctagatatagaaagcactAgtaaaagggtctacaaacag	18	8	9	6	0	2	2	0	0	2	2	2	2	2	2	0	1	3	2	0	1	9	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:180065045A>G	uc001gnt.2	+	35	9282	c.8899A>G	c.(8899-8901)AGT>GGT	p.S2967G	CEP350_uc009wxl.2_Missense_Mutation_p.S2966G|CEP350_uc001gnv.2_Missense_Mutation_p.S1102G|CEP350_uc001gnw.1_Missense_Mutation_p.S724G|CEP350_uc001gnx.1_Missense_Mutation_p.S724G	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2967						centrosome|nucleus|spindle				ovary(4)	4						AGAAAGCACTAGTAAAAGGGT	0.343													12	14					0	0	0	0	G	180065045	G	G	180065045	3	3	34	1	0	0	0	0	1	0	0	0	3269	420	15	5	9033	5	CEP350	1	180065045	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	964461	180065045	69185576	39	6331											
C1orf27	54953	broad.mit.edu	37	chr1	186359971	186359971	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgtcagctatactctggaGaaaaatacaaaggtaccagg	15	9	9	8	0	3	1	1	0	2	1	3	2	3	1	1	3	4	2	1	3	7	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:186359971G>C	uc001grw.2	+	7	839	c.603G>C	c.(601-603)GAG>GAC	p.E201D	C1orf27_uc010poq.1_Missense_Mutation_p.E201D|C1orf27_uc010por.1_Missense_Mutation_p.E169D	NM_017847	NP_060317	Q5SWX8	ODR4_HUMAN	odorant response abnormal 4 isoform 1	201						integral to membrane	oxidoreductase activity|zinc ion binding			ovary(1)	1						ATACTCTGGAGAAAAATACAA	0.353													12	20					0	0	0	0	C	186359971	C	C	186359971	3	2	34	1	0	0	0	0	1	0	0	0	2046	933	33	2	625	2	C1orf27	1	186359971	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	6294926	186359971	62890650	40	6332											
KCNT2	343450	broad.mit.edu	37	chr1	196250048	196250048	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccaatgggaacatctccaGtagaagaacacaacttctga	15	9	7	10	0	2	3	0	1	2	2	4	4	3	4	2	1	3	1	2	1	6	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:196250048G>T	uc001gtd.1	-	25	2912	c.2852C>A	c.(2851-2853)ACT>AAT	p.T951N	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.T877N|KCNT2_uc001gtf.1_Missense_Mutation_p.T927N|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.T927N|KCNT2_uc001gth.1_Missense_Mutation_p.T448N	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	951	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						AACATCTCCAGTAGAAGAACA	0.333													29	47					1.56442e-22	2.06066e-22	1	0	T	196250048	T	T	196250048	3	4	34	1	0	0	0	0	1	0	0	0	8131	1029	36	4	571	4	KCNT2	1	196250048	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	9890077	196250048	53000573	41	6333											
CFHR5	81494	broad.mit.edu	37	chr1	196965167	196965167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttagaacaagtgaaaacatGtggatacatacctgaactcg	16	9	8	8	1	0	3	0	2	0	1	1	4	0	4	1	1	5	0	1	1	8	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:196965167G>A	uc001gts.3	+	6	934	c.806G>A	c.(805-807)TGT>TAT	p.C269Y		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	269	Sushi 5.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						GTGAAAACATGTGGATACATA	0.343													30	143					0	0	0	0	A	196965167	A	A	196965167	3	1	34	1	0	0	0	0	1	0	0	0	3303	1377	48	4	828	4	CFHR5	1	196965167	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	715119	196965167	52285454	42	6334											
CRB1	23418	broad.mit.edu	37	chr1	197391059	197391059	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accagtgtgactgccacaggCcctatgaaggccccaactgt	10	7	10	14	0	0	2	0	2	0	0	0	2	0	2	5	2	2	0	5	2	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:197391059C>A	uc001gtz.2	+	6	2236	c.2101C>A	c.(2101-2103)CCC>ACC	p.P701T	CRB1_uc010poz.1_Missense_Mutation_p.P632T|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.P589T|CRB1_uc010ppb.1_Missense_Mutation_p.P701T|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.P182T|CRB1_uc001gub.1_Missense_Mutation_p.P350T	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	701	Extracellular (Potential).|EGF-like 12.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CTGCCACAGGCCCTATGAAGG	0.532													34	41					4.62619e-21	5.98109e-21	1	0	A	197391059	A	A	197391059	3	1	34	1	0	0	0	0	1	0	0	0	3863	739	26	4	2123	4	CRB1	1	197391059	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	425892	197391059	51859562	43	6335											
ADORA1	134	broad.mit.edu	37	chr1	203098090	203098090	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaaggtgaaccaggcgctgCgggatgccaccttctgcttc	7	9	13	12	2	1	2	0	2	1	0	2	3	1	3	3	3	4	2	3	3	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:203098090C>T	uc001gze.1	+	3	554	c.121C>T	c.(121-123)CGG>TGG	p.R41W	ADORA1_uc001gzf.1_Missense_Mutation_p.R41W|ADORA1_uc010pqg.1_5'UTR|ADORA1_uc009xak.1_5'UTR|ADORA1_uc010pqh.1_Missense_Mutation_p.R74W	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	41	Cytoplasmic (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	CCAGGCGCTGCGGGATGCCAC	0.637													114	175					0	0	0	0	T	203098090	T	T	203098090	3	4	34	1	0	0	0	0	1	0	0	0	326	759	27	1	123	1	ADORA1	1	203098090	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	5707031	203098090	46152531	44	6336											
PRELP	5549	broad.mit.edu	37	chr1	203455927	203455927	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccacacctgcgctacctgcGgctggatggaaactacttga	9	8	11	13	2	0	1	0	1	0	0	0	3	0	3	3	3	5	2	3	3	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:203455927G>A	uc001gzs.2	+	3	1267	c.1067G>A	c.(1066-1068)CGG>CAG	p.R356Q	PRELP_uc001gzt.2_Missense_Mutation_p.R356Q	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	356	LRR 11.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			CGCTACCTGCGGCTGGATGGA	0.597													27	34					0	0	0	0	A	203455927	A	A	203455927	3	1	34	1	0	0	0	0	1	0	0	0	12535	1116	39	1	1073	1	PRELP	1	203455927	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	357837	203455927	45794694	45	6337											
PIK3C2B	5287	broad.mit.edu	37	chr1	204394033	204394033	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaccagccggtcttctcctGagccaggtccagctctcgca	7	8	10	16	2	3	1	0	1	3	0	6	2	4	1	5	2	4	2	5	2	1	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:204394033G>C	uc001haw.2	-	34	5331	c.4852C>G	c.(4852-4854)CAG>GAG	p.Q1618E	PIK3C2B_uc010pqv.1_Missense_Mutation_p.Q1590E	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1618					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GTCTTCTCCTGAGCCAGGTCC	0.642													14	53					0	0	0	0	C	204394033	C	C	204394033	3	2	34	1	0	0	0	0	1	0	0	0	11965	1299	45	2	56	2	PIK3C2B	1	204394033	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	938106	204394033	44856588	46	6338											
ELK4	2005	broad.mit.edu	37	chr1	205589479	205589479	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggcttccagggaaggcagtTttggggaaaccaatgtctcc	9	9	14	9	0	1	0	0	0	1	0	3	2	2	2	3	5	1	3	3	5	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:205589479T>A	uc001hcy.1	-	3	1945	c.695A>T	c.(694-696)AAA>ATA	p.K232I	ELK4_uc001hcz.2_Missense_Mutation_p.K232I	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	232						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GGAAGGCAGTTTTGGGGAAAC	0.507			T	SLC45A3	prostate								29	108					0	0	0	0	A	205589479	A	A	205589479	3	1	34	1	0	0	0	0	1	0	0	0	5085	1841	64	5	750	5	ELK4	1	205589479	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	1195446	205589479	43661142	47	6339											
IRF6	3664	broad.mit.edu	37	chr1	209963078	209963078	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttccccaaagcataagtaGatctcaaacggtggctgctt	11	11	8	11	1	2	1	1	0	2	1	4	1	3	1	2	2	3	4	2	2	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:209963078G>C	uc001hhq.1	-	8	1376	c.1113C>G	c.(1111-1113)ATC>ATG	p.I371M	IRF6_uc010psm.1_Missense_Mutation_p.I276M|IRF6_uc009xct.1_Missense_Mutation_p.I371M	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	371					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		AGCATAAGTAGATCTCAAACG	0.453										HNSCC(57;0.16)			17	64					0	0	0	0	C	209963078	C	C	209963078	3	2	34	1	0	0	0	0	1	0	0	0	7873	932	33	2	298	2	IRF6	1	209963078	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	4373599	209963078	39287543	48	6340											
PROX1	5629	broad.mit.edu	37	chr1	214185035	214185035	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acagggctctgaacatgcacTacaataaagcaaatgacttt	16	9	7	9	0	1	2	0	2	1	0	1	2	1	2	0	1	4	3	0	1	6	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:214185035T>A	uc001hkh.2	+	4	2277	c.2005T>A	c.(2005-2007)TAC>AAC	p.Y669N		NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	669	Prospero-like.				aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GAACATGCACTACAATAAAGC	0.393													34	67					0	0	0	0	A	214185035	A	A	214185035	3	1	34	1	0	0	0	0	1	0	0	0	12622	1522	53	5	2015	5	PROX1	1	214185035	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	4221957	214185035	35065586	49	6341											
CAPN2	824	broad.mit.edu	37	chr1	223934731	223934731	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctatgaagcgctatcaggggGtgccaccactgagggcttcg	8	8	14	11	2	1	2	1	2	0	0	2	2	1	2	2	3	2	2	2	3	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:223934731G>T	uc001hob.3	+	5	817	c.593G>T	c.(592-594)GGT>GTT	p.G198V	CAPN2_uc010puy.1_Missense_Mutation_p.G120V	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	198	Calpain catalytic.				proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		CTATCAGGGGGTGCCACCACT	0.517													26	121					2.79863e-10	3.14525e-10	1	0	T	223934731	T	T	223934731	3	4	34	1	0	0	0	0	1	0	0	0	2639	1261	44	4	618	4	CAPN2	1	223934731	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	9749696	223934731	25315890	50	6342											
LYST	1130	broad.mit.edu	37	chr1	235937202	235937202	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tctaacagcttaacatcttgGattatagcattagagtctac	13	14	6	8	0	3	1	0	0	3	1	3	2	3	2	0	1	5	2	0	1	6	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:235937202G>C	uc001hxj.2	-	19	5899	c.5724C>G	c.(5722-5724)ATC>ATG	p.I1908M	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1908					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TAACATCTTGGATTATAGCAT	0.318									Chediak-Higashi_syndrome				23	80					0	0	0	0	C	235937202	C	C	235937202	3	2	34	1	0	0	0	0	1	0	0	0	9179	1164	41	2	5821	2	LYST	1	235937202	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	12002471	235937202	13313419	51	6343											
FMN2	56776	broad.mit.edu	37	chr1	240370401	240370401	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctcctgtggatgggctGccagggcgtcctccatgccc	3	9	13	16	1	0	0	0	0	0	0	3	1	3	1	6	3	3	1	6	3	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:240370401G>C	uc010pyd.1	+	5	2514	c.2289G>C	c.(2287-2289)CTG>CTC	p.L763L	FMN2_uc010pye.1_Silent_p.L767L	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	763	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TGGATGGGCTGCCAGGGCGTC	0.537													20	44					0	0	0	0	C	240370401	C	C	240370401	2	2	34	1	0	0	0	0	0	0	0	1	5982	1306	46	4		4	FMN2	1	240370401	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	4433199	240370401	8880220	52	6344											
OR6F1	343169	broad.mit.edu	37	chr1	247875357	247875357	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtggagaaggctttgctcCggccactggcagaggggatc	8	7	16	10	2	0	2	0	0	0	2	2	4	1	3	2	6	1	3	2	6	1	1	rs138204394		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:247875357C>A	uc001idj.1	-	1	701	c.701G>T	c.(700-702)CGG>CTG	p.R234L		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGCTTTGCTCCGGCCACTGGC	0.527													49	195					3.19069e-20	4.08208e-20	1	0	A	247875357	A	A	247875357	3	1	34	1	0	0	0	0	1	0	0	0	11255	652	23	3	229	3	OR6F1	1	247875357	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	7504956	247875357	1375264	53	6345											
OR2L13	284521	broad.mit.edu	37	chr1	248263111	248263111	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gatgtgtgtgaagatgattgGaggctcttggacactggggt	8	12	17	4	0	1	3	0	2	1	1	1	6	1	5	0	5	0	1	0	5	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:248263111G>C	uc001ids.2	+	3	771	c.434G>C	c.(433-435)GGA>GCA	p.G145A		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			AAGATGATTGGAGGCTCTTGG	0.483													57	280					0	0	0	0	C	248263111	C	C	248263111	3	2	34	1	0	0	0	0	1	0	0	0	11060	1174	41	2	436	2	OR2L13	1	248263111	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	387754	248263111	987510	54	6346											
OR2M3	127062	broad.mit.edu	37	chr1	248367182	248367182	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcgctccccaacacaggaCaagatggtgtctgtattcta	11	10	9	11	1	2	1	0	0	2	1	4	3	3	2	2	2	1	2	2	2	4	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr1:248367182C>A	uc010pzg.1	+	1	813	c.813C>A	c.(811-813)GAC>GAA	p.D271E		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CAACACAGGACAAGATGGTGT	0.488													47	198					4.01344e-20	5.12131e-20	1	0	A	248367182	A	A	248367182	3	1	34	1	0	0	0	0	1	0	0	0	11065	477	17	4	815	4	OR2M3	1	248367182	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	104071	248367182	883439	55	6347											
FAM110C	642273	broad.mit.edu	37	chr2	46008	46008	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccttacccggcccctggaaGagcttcttcaccaggcttgc	6	10	9	16	1	2	1	1	0	1	1	3	2	3	2	5	3	3	2	5	3	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:46008G>C	uc010yim.1	-	1	378	c.378C>G	c.(376-378)CTC>CTG	p.L126L		NM_001077710	NP_001071178	Q1W6H9	F110C_HUMAN	hypothetical protein LOC642273	126						microtubule|microtubule organizing center|spindle pole					0	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		GCCCCTGGAAGAGCTTCTTCA	0.687													8	35					0	0	0	0	C	46008	C	C	46008	2	2	34	1	0	0	0	0	0	0	0	1	5426	929	33	2		2	FAM110C	2	46008	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08		46008	243153365	56	6348											
KIDINS220	57498	broad.mit.edu	37	chr2	8874867	8874867	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttacactgagctaacacaCggccatttatgtttgcctga	10	13	8	10	1	0	2	0	2	0	0	0	2	0	2	2	1	4	3	2	1	3	5	rs61742970		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:8874867C>G	uc002qzc.2	-	28	3916	c.3734G>C	c.(3733-3735)CGT>CCT	p.R1245P	KIDINS220_uc010yiv.1_Missense_Mutation_p.R954P|KIDINS220_uc002qzd.2_Missense_Mutation_p.R1146P|KIDINS220_uc010yiw.1_Missense_Mutation_p.R1189P|KIDINS220_uc002qzb.2_Missense_Mutation_p.R99P	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1245	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AGCTAACACACGGCCATTTAT	0.333													12	45					0	0	0	0	G	8874867	G	G	8874867	3	3	34	1	0	0	0	0	1	0	0	0	8310	536	19	3	1593	3	KIDINS220	2	8874867	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	8828859	8874867	234324506	57	6349											
SMC6	79677	broad.mit.edu	37	chr2	17896314	17896314	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaagcaagttctgggtccCgaagatgaatgcaagctcct	12	8	10	11	1	1	2	0	1	1	1	3	3	3	2	3	1	3	4	3	1	5	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:17896314C>A	uc002rco.2	-	16	1840	c.1544G>T	c.(1543-1545)CGG>CTG	p.R515L	SMC6_uc010exo.2_Missense_Mutation_p.R515L|SMC6_uc002rcn.2_Missense_Mutation_p.R515L|SMC6_uc002rcp.1_Missense_Mutation_p.R541L|SMC6_uc002rcq.2_Missense_Mutation_p.R541L	NM_001142286	NP_001135758	Q96SB8	SMC6_HUMAN	SMC6 protein	515	Flexible hinge.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTCTGGGTCCCGAAGATGAAT	0.388													21	60					1.9806e-07	2.14711e-07	1	0	A	17896314	A	A	17896314	3	1	34	1	0	0	0	0	1	0	0	0	14851	652	23	3	1783	3	SMC6	2	17896314	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	9021447	17896314	225303059	58	6350											
APOB	338	broad.mit.edu	37	chr2	21232560	21232560	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcatcatcaataaatccaaCcaatttctcaaagtaatctt	17	12	2	10	0	4	0	3	0	2	0	6	0	5	0	2	0	2	2	2	0	7	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:21232560C>A	uc002red.2	-	26	7308	c.7180G>T	c.(7180-7182)GTT>TTT	p.V2394F		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2394					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATAAATCCAACCAATTTCTCA	0.308													9	22					3.09899e-07	3.3521e-07	1	0	A	21232560	A	A	21232560	3	1	34	1	0	0	0	0	1	0	0	0	785	507	18	4	6527	4	APOB	2	21232560	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	3336246	21232560	221966813	59	6351											
APOB	338	broad.mit.edu	37	chr2	21250809	21250809	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	taagattcccttctattttgGctgaggctgggtcaagtgat	8	15	11	7	0	2	3	1	2	1	1	3	3	3	3	1	3	0	2	1	3	3	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:21250809G>A	uc002red.2	-	14	2086	c.1958C>T	c.(1957-1959)GCC>GTC	p.A653V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	653	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCTATTTTGGCTGAGGCTGG	0.398													34	96					0	0	0	0	A	21250809	A	A	21250809	3	1	34	1	0	0	0	0	1	0	0	0	785	1203	42	4	11797	4	APOB	2	21250809	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	18249	21250809	221948564	60	6352											
BRE	9577	broad.mit.edu	37	chr2	28521258	28521258	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caactctcacatttcagtccGtttatcactttaccaacagt	11	14	3	13	1	3	0	3	0	1	0	5	0	4	0	2	0	3	1	2	0	4	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:28521258G>T	uc002rlr.2	+	12	1306	c.988G>T	c.(988-990)GTT>TTT	p.V330F	BRE_uc002rlp.1_Missense_Mutation_p.V330F|BRE_uc002rlq.2_Missense_Mutation_p.V330F|BRE_uc002rls.2_Missense_Mutation_p.V330F|BRE_uc002rlt.2_Missense_Mutation_p.V330F|BRE_uc002rlu.2_Missense_Mutation_p.V330F|BRE_uc002rlv.2_Missense_Mutation_p.V192F|BRE_uc002rlx.2_RNA	NM_199194	NP_954664	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A	330	UEV-like 2.				apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			lung(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					ATTTCAGTCCGTTTATCACTT	0.433													69	202					3.41413e-29	4.63414e-29	1	0	T	28521258	T	T	28521258	3	4	34	1	0	0	0	0	1	0	0	0	1514	1145	40	3	1026	3	BRE	2	28521258	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	7270449	28521258	214678115	61	6353											
SIX3	6496	broad.mit.edu	37	chr2	45170030	45170030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accggcggcagcgcgaccgcGccgcggcggccaagaacagg	8	0	17	16	9	0	1	0	0	0	1	0	2	0	1	4	5	2	1	4	5	2	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:45170030G>A	uc002run.1	+	1	994	c.787G>A	c.(787-789)GCC>ACC	p.A263T		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	263	Homeobox.|Poly-Ala.				visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GCGCGACCGCGCCGCGGCGGC	0.677													8	19					0	0	0	0	A	45170030	A	A	45170030	3	1	34	1	0	0	0	0	1	0	0	0	14413	1087	38	1	789	1	SIX3	2	45170030	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	16648772	45170030	198029343	62	6354											
SOCS5	9655	broad.mit.edu	37	chr2	46986867	46986867	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccttctcgaagggaaacctGaaggcacgtttttgctcagg	9	10	11	11	2	2	1	1	1	1	0	3	3	2	2	2	3	2	3	2	3	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:46986867G>A	uc002rvf.2	+	2	1362	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	SOCS5_uc010yoe.1_Missense_Mutation_p.E369K|SOCS5_uc002rvg.2_Missense_Mutation_p.E400K	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	400	SH2.				cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			AGGGAAACCTGAAGGCACGTT	0.527													20	35					0	0	0	0	A	46986867	A	A	46986867	3	1	34	1	0	0	0	0	1	0	0	0	14981	1291	45	2	1200	2	SOCS5	2	46986867	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1816837	46986867	196212506	63	6355											
FBXO11	80204	broad.mit.edu	37	chr2	48066599	48066599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagacactcttgcacgttttGcacgatgaccaaagttttct	10	13	7	11	2	2	2	0	1	2	1	2	3	2	2	1	0	2	4	1	0	1	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:48066599G>A	uc010fbl.2	-	3	263	c.149C>T	c.(148-150)GCA>GTA	p.A50V	FBXO11_uc002rwe.2_Missense_Mutation_p.A50V|FBXO11_uc002rwf.2_Missense_Mutation_p.A50V|FBXO11_uc002rwg.1_Missense_Mutation_p.A50V	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	134					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TGCACGTTTTGCACGATGACC	0.328													12	47					0	0	0	0	A	48066599	A	A	48066599	3	1	34	1	0	0	0	0	1	0	0	0	5759	1319	46	4	2556	4	FBXO11	2	48066599	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1079732	48066599	195132774	64	6356											
FANCL	55120	broad.mit.edu	37	chr2	58425730	58425730	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacctgaggagaatttaccTgaggtgtccaggaggcacaa	12	9	12	8	0	0	3	0	2	0	1	1	5	1	4	3	4	2	1	3	4	4	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:58425730T>A	uc002rzw.3	-	7	606	c.539A>T	c.(538-540)CAG>CTG	p.Q180L	FANCL_uc002rzx.3_Missense_Mutation_p.Q180L|FANCL_uc010fce.2_Missense_Mutation_p.Q180L|FANCL_uc010fcf.1_Missense_Mutation_p.Q121L	NM_018062	NP_060532	Q9NW38	FANCL_HUMAN	Fanconi anemia, complementation group L isoform	180					DNA repair	cytoplasm|nucleoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						AGAATTTACCTGAGGTGTCCA	0.244								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				15	45					0	0	0	0	A	58425730	A	A	58425730	3	1	34	1	0	0	0	0	1	0	0	0	5702	1594	55	5	635	5	FANCL	2	58425730	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	10359131	58425730	184773643	65	6357											
MRPL19	9801	broad.mit.edu	37	chr2	75882378	75882378	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaaaaattgaagctgcaatAtggaaggaaattgaagcgtc	17	9	10	5	1	1	2	1	2	0	0	2	4	1	4	0	2	3	2	0	2	8	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:75882378A>G	uc002snl.2	+	6	871	c.846A>G	c.(844-846)ATA>ATG	p.I282M	MRPL19_uc002snm.1_Missense_Mutation_p.I282M	NM_014763	NP_055578	P49406	RM19_HUMAN	mitochondrial ribosomal protein L19 precursor	282					translation	mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome				0						AAGCTGCAATATGGAAGGAAA	0.363													22	53					0	0	0	0	G	75882378	G	G	75882378	3	3	34	1	0	0	0	0	1	0	0	0	9837	439	16	5	868	5	MRPL19	2	75882378	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	17456648	75882378	167316995	66	6358											
ST3GAL5	8869	broad.mit.edu	37	chr2	86073500	86073501	+	Frame_Shift_Ins	INS	-	A	A																															tagaagtattagtgcttaccINSagggtttccttttttaccat																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:86073500_86073501insA	uc002sqq.1	-	5	977_978	c.848_849insT	c.(847-849)CTGfs	p.L283fs	ST3GAL5_uc010fgq.1_Frame_Shift_Ins_p.L155fs|ST3GAL5_uc002sqp.1_Frame_Shift_Ins_p.L260fs	NM_003896	NP_003887	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	283	Lumenal (Potential).				ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity				0						TAGTGCTTACCAGGGTTTCCTT	0.332													---	---	---								A	86073501	A	A	86073500	7	5	34	1	0	1	1	0	0	0	0	0	15284	608	21	0	419	0	ST3GAL5	2	86073500	Frame_Shift_Ins	INS	-	TCGA-BB-7871-01A-11D-2229-08	10191122	86073500	157125873	67	6359											
ZNF514	84874	broad.mit.edu	37	chr2	95818878	95818878	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttggagggcttgtgctcacCcagaatggccaagttcctga	8	11	12	10	0	1	2	1	1	0	1	2	3	2	3	3	3	1	3	3	3	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:95818878C>A	uc002sue.1	-	3	495	c.121G>T	c.(121-123)GGC>TGC	p.G41C	ZNF514_uc002sud.1_Missense_Mutation_p.G114C	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGTGCTCACCCAGAATGGCC	0.547													21	71					1.66031e-10	1.88322e-10	1	0	A	95818878	A	A	95818878	3	1	34	1	0	0	0	0	1	0	0	0	18026	637	22	4	1093	4	ZNF514	2	95818878	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	9745378	95818878	147380495	68	6360											
ASTL	431705	broad.mit.edu	37	chr2	96803335	96803335	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttggttaattgcaggaatgtCcttgtccccggaggcctggg	6	12	14	9	1	0	0	0	0	0	0	2	2	2	2	4	5	1	2	4	5	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:96803335C>T	uc010yui.1	-	2	160	c.160G>A	c.(160-162)GAC>AAC	p.D54N		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	54					proteolysis		metalloendopeptidase activity|zinc ion binding				0						GCAGGAATGTCCTTGTCCCCG	0.587													54	128					0	0	0	0	T	96803335	T	T	96803335	3	4	34	1	0	0	0	0	1	0	0	0	1065	855	30	2	1166	2	ASTL	2	96803335	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	984457	96803335	146396038	69	6361											
FBLN7	129804	broad.mit.edu	37	chr2	112933379	112933379	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgcatttgtcctccaggAaggactgggaaccgctgtca	10	9	12	10	1	1	1	1	0	0	1	3	4	3	4	3	3	2	2	3	3	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:112933379A>G	uc002tho.1	+	4	766	c.495A>G	c.(493-495)GGA>GGG	p.G165G	FBLN7_uc002thn.2_Silent_p.G165G|FBLN7_uc010fki.1_Silent_p.G165G|FBLN7_uc010fkj.1_Intron	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	165	EGF-like 1; calcium-binding (Potential).				cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						GTCCTCCAGGAAGGACTGGGA	0.527													29	82					0	0	0	0	G	112933379	G	G	112933379	2	3	34	1	0	0	0	0	0	0	0	1	5733	233	9	5		5	FBLN7	2	112933379	Silent	SNP	A	TCGA-BB-7871-01A-11D-2229-08	16130044	112933379	130265994	70	6362											
RGPD5	84220	broad.mit.edu	37	chr2	113147642	113147642	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctacttgtttggccaaaaatCacaccacggcccttcttccg	9	11	6	15	2	2	0	1	0	1	0	3	0	3	0	4	2	1	1	4	2	3	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:113147642C>G	uc002ths.1	-	20	2957	c.2880G>C	c.(2878-2880)GTG>GTC	p.V960V	RGPD8_uc010fkk.1_Silent_p.V820V|RGPD5_uc002tht.1_Silent_p.V211V	NM_005054	NP_005045	Q99666	RGPD5_HUMAN	RANBP2-like and GRIP domain containing 5 isoform	960					intracellular transport	cytoplasm	binding				0						GGCCAAAAATCACACCACGGC	0.423													45	162					0	0	0	0	G	113147642	G	G	113147642	2	3	34	1	0	0	0	0	0	0	0	1	13354	813	29	2		2	RGPD5	2	113147642	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	214263	113147642	130051731	71	6363											
POTEF	728378	broad.mit.edu	37	chr2	130832532	130832532	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgtacagggacagcacaGcctggatggccacgtacatg	11	6	14	10	1	0	0	0	0	0	0	0	2	0	2	2	4	4	3	2	4	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:130832532G>T	uc010fmh.2	-	17	2913	c.2513C>A	c.(2512-2514)GCT>GAT	p.A838D		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	838	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						GGACAGCACAGCCTGGATGGC	0.587													40	217					5.57489e-27	7.50466e-27	1	0	T	130832532	T	T	130832532	3	4	34	1	0	0	0	0	1	0	0	0	12320	971	34	4	718	4	POTEF	2	130832532	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	17684890	130832532	112366841	72	6364											
ZEB2	9839	broad.mit.edu	37	chr2	145161496	145161496	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccccacctgatctgtccctGgcttgtgtgtcaccatatgc	5	12	8	16	0	2	1	1	1	1	0	3	1	3	1	5	1	1	1	5	1	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:145161496G>T	uc002tvu.2	-	6	1274	c.794C>A	c.(793-795)CCA>CAA	p.P265Q	ZEB2_uc002tvv.2_Missense_Mutation_p.P259Q|ZEB2_uc010zbm.1_Missense_Mutation_p.P236Q|ZEB2_uc010fnp.2_Missense_Mutation_p.P173Q|ZEB2_uc010fnq.1_Missense_Mutation_p.P294Q	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	265						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		ATCTGTCCCTGGCTTGTGTGT	0.393													44	149					1.23713e-20	1.59106e-20	1	0	T	145161496	T	T	145161496	3	4	34	1	0	0	0	0	1	0	0	0	17691	1348	47	4	2870	4	ZEB2	2	145161496	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	14328964	145161496	98037877	73	6365											
GALNT5	11227	broad.mit.edu	37	chr2	158114943	158114943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaaagaaaaatgcagaatGccctgggaaggggcaaggtt	15	5	16	5	0	0	2	0	0	0	2	0	4	0	4	1	5	2	3	1	5	6	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:158114943G>A	uc002tzg.2	+	1	604	c.349G>A	c.(349-351)GCC>ACC	p.A117T	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	117	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						AATGCAGAATGCCCTGGGAAG	0.532													26	98					0	0	0	0	A	158114943	A	A	158114943	3	1	34	1	0	0	0	0	1	0	0	0	6251	1319	46	4	351	4	GALNT5	2	158114943	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	12953447	158114943	85084430	74	6366											
GCA	25801	broad.mit.edu	37	chr2	163216037	163216037	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagagaccacttgcaacaagGgtctgcgaatttcatatatg	14	10	9	8	1	2	1	1	0	1	1	2	3	2	1	1	1	3	1	1	1	6	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:163216037G>T	uc002ucg.2	+	7	778	c.602G>T	c.(601-603)GGG>GTG	p.G201V	GCA_uc010zcu.1_Missense_Mutation_p.G182V	NM_012198	NP_036330	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	201					cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity				0						TTGCAACAAGGGTCTGCGAAT	0.294													13	35					0.000566183	0.000582836	1	0	T	163216037	T	T	163216037	3	4	34	1	0	0	0	0	1	0	0	0	6318	1232	43	4	628	4	GCA	2	163216037	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	5101094	163216037	79983336	75	6367											
SCN7A	6332	broad.mit.edu	37	chr2	167273291	167273291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attttcccatagcatggattCgttaaacagaaggctttcac	12	13	7	9	1	1	1	1	0	0	1	3	2	2	2	1	2	2	3	1	2	4	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:167273291C>T	uc002udu.1	-	20	3467	c.3340G>A	c.(3340-3342)GAA>AAA	p.E1114K	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1114					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AGCATGGATTCGTTAAACAGA	0.378													7	23					0	0	0	0	T	167273291	T	T	167273291	3	4	34	1	0	0	0	0	1	0	0	0	13988	893	31	1	1732	1	SCN7A	2	167273291	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	4057254	167273291	75926082	76	6368											
FASTKD1	79675	broad.mit.edu	37	chr2	170419780	170419781	+	Frame_Shift_Ins	INS	-	T	T																															cctatgaacaatatcagctaINStttttcccattaatggacta																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:170419780_170419781insT	uc002uev.3	-	4	914_915	c.526_527insA	c.(526-528)ATAfs	p.I176fs	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Frame_Shift_Ins_p.I162fs|FASTKD1_uc002uey.2_Frame_Shift_Ins_p.I139fs	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	176					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						AATATCAGCTATTTTTCCCATT	0.267													---	---	---								T	170419781	T	T	170419780	7	5	34	1	0	1	1	0	0	0	0	0	5717	449	16	0	2064	0	FASTKD1	2	170419780	Frame_Shift_Ins	INS	-	TCGA-BB-7871-01A-11D-2229-08	3146489	170419780	72779593	77	6369											
HOXD12	3238	broad.mit.edu	37	chr2	176965471	176965471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcgtggtgcttcgggagcagGcgctggcgctctactagccg	4	8	17	12	5	1	0	0	0	1	0	2	1	1	1	1	4	4	4	1	4	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:176965471G>A	uc010zev.1	+	2	796	c.796G>A	c.(796-798)GCG>ACG	p.A266T	HOXD12_uc010zew.1_3'UTR	NM_021193	NP_067016	P35452	HXD12_HUMAN	homeobox D12	266						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		TCGGGAGCAGGCGCTGGCGCT	0.592													6	15					0	0	0	0	A	176965471	A	A	176965471	3	1	34	1	0	0	0	0	1	0	0	0	7360	1203	42	4	802	4	HOXD12	2	176965471	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	6545691	176965471	66233902	78	6370											
HOXD10	3236	broad.mit.edu	37	chr2	176981711	176981711	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggacctatggaatgcaaacCtgtggactgctcccgtctct	8	10	11	12	1	1	0	0	0	1	0	3	3	2	3	3	3	3	2	3	3	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:176981711C>A	uc002ukj.2	+	1	220	c.150C>A	c.(148-150)ACC>ACA	p.T50T		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	50						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GAATGCAAACCTGTGGACTGC	0.493													27	78					1.74807e-11	2.01542e-11	1	0	A	176981711	A	A	176981711	2	1	34	1	0	0	0	0	0	0	0	1	7358	668	24	4		4	HOXD10	2	176981711	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	16240	176981711	66217662	79	6371											
HOXD1	3231	broad.mit.edu	37	chr2	177054082	177054082	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccagaccgcatccccggccCcaggcacctaccccaagtcc	8	4	7	22	2	0	1	0	0	0	1	3	1	3	1	10	2	1	2	10	2	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:177054082C>A	uc002ukv.3	+	1	776	c.553C>A	c.(553-555)CCA>ACA	p.P185T	HOXD1_uc010fqy.2_Missense_Mutation_p.P185T|HOXD1_uc010zez.1_Missense_Mutation_p.P185T	NM_024501	NP_078777	Q9GZZ0	HXD1_HUMAN	homeobox D1	185						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.0226)		ATCCCCGGCCCCAGGCACCTA	0.637													7	18					5.4927e-09	6.0892e-09	1	0	A	177054082	A	A	177054082	3	1	34	1	0	0	0	0	1	0	0	0	7357	623	22	4	555	4	HOXD1	2	177054082	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	72371	177054082	66145291	80	6372											
PDE11A	50940	broad.mit.edu	37	chr2	178936874	178936874	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccggcccagctgggactcaaGggaaccccaccacagtcccc	9	3	10	19	1	1	0	1	0	0	0	2	2	2	2	7	3	2	1	7	3	2	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:178936874G>T	uc002ulq.2	-	1	609	c.291C>A	c.(289-291)CCC>CCA	p.P97P	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	97					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TGGGACTCAAGGGAACCCCAC	0.647									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				22	39					5.35356e-11	6.11479e-11	1	0	T	178936874	T	T	178936874	2	4	34	1	0	0	0	0	0	0	0	1	11685	987	35	4		4	PDE11A	2	178936874	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1882792	178936874	64262499	81	6373											
TTN	7273	broad.mit.edu	37	chr2	179466434	179466434	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttgtcctgctttattcttGgctgtgatgctgtatttgcc	3	21	9	8	0	1	1	0	1	1	0	2	1	2	1	2	1	3	4	2	1	2	8			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:179466434G>A	uc010zfg.1	-	235	47903	c.47679C>T	c.(47677-47679)GCC>GCT	p.A15893A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.A9588A|TTN_uc010zfi.1_Silent_p.A9521A|TTN_uc010zfj.1_Silent_p.A9396A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16820							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTATTCTTGGCTGTGATGC	0.353													24	47					0	0	0	0	A	179466434	A	A	179466434	2	1	34	1	0	0	0	0	0	0	0	1	16803	1335	47	4		4	TTN	2	179466434	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	529560	179466434	63732939	82	6374											
TTN	7273	broad.mit.edu	37	chr2	179489296	179489296	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	taacaagttttctgaccctgCcatcagcaacaatttcatac	13	12	4	12	0	3	1	2	1	1	0	3	1	3	1	2	0	5	2	2	0	5	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:179489296C>G	uc010zfg.1	-	191	37231	c.37007G>C	c.(37006-37008)GGC>GCC	p.G12336A	TTN_uc010zfh.1_Missense_Mutation_p.G6031A|TTN_uc010zfi.1_Missense_Mutation_p.G5964A|TTN_uc010zfj.1_Missense_Mutation_p.G5839A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13263							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGACCCTGCCATCAGCAAC	0.393													11	55					0	0	0	0	G	179489296	G	G	179489296	3	3	34	1	0	0	0	0	1	0	0	0	16803	739	26	4	63466	4	TTN	2	179489296	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	22862	179489296	63710077	83	6375											
TTN	7273	broad.mit.edu	37	chr2	179584424	179584424	+	Frame_Shift_Del	DEL	T	-	-																															atgtaatgtgatgtttgctgTctgcagacaattctcttcca																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:179584424delT	uc010zfg.1	-	79	20287	c.20063delA	c.(20062-20064)GACfs	p.D6688fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.D3349fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7615							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTTTGCTGTCTGCAGACAA	0.403													---	---	---								-	179584424	-	-	179584424	7	5	34	1	0	1	0	1	0	0	0	0	16803	1667	58	0	80858	0	TTN	2	179584424	Frame_Shift_Del	DEL	T	TCGA-BB-7871-01A-11D-2229-08	95128	179584424	63614949	84	6376											
TTN	7273	broad.mit.edu	37	chr2	179584473	179584473	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccacttggctgagagttctgGtgttccagtcactacacact	8	12	9	12	0	2	1	1	1	1	1	3	2	3	1	2	2	1	3	2	2	1	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:179584473G>C	uc010zfg.1	-	79	20238	c.20014C>G	c.(20014-20016)CCA>GCA	p.P6672A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P3333A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7599							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGAGTTCTGGTGTTCCAGTC	0.418													13	60					0	0	0	0	C	179584473	C	C	179584473	3	2	34	1	0	0	0	0	1	0	0	0	16803	1261	44	4	80907	4	TTN	2	179584473	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	49	179584473	63614900	85	6377											
TTN	7273	broad.mit.edu	37	chr2	179597007	179597007	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtaccagttactttgcaggcTagctgggtggcatctccctt	6	13	11	11	0	1	0	0	0	1	0	2	0	1	0	2	3	4	6	2	3	3	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:179597007T>A	uc010zfg.1	-	54	13181	c.12957A>T	c.(12955-12957)CTA>CTT	p.L4319L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.L980L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5246							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTGCAGGCTAGCTGGGTGG	0.408													30	88					0	0	0	0	A	179597007	A	A	179597007	2	1	34	1	0	0	0	0	0	0	0	1	16803	1509	53	5		5	TTN	2	179597007	Silent	SNP	T	TCGA-BB-7871-01A-11D-2229-08	12534	179597007	63602366	86	6378											
TTN	7273	broad.mit.edu	37	chr2	179598042	179598042	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtgtattggccactgtcGtgcagctcagctgaataaaa	12	11	10	8	1	1	1	1	1	0	0	2	1	1	1	1	1	3	4	1	1	5	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:179598042G>A	uc010zfg.1	-	51	12470	c.12246C>T	c.(12244-12246)CAC>CAT	p.H4082H	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.H743H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5009							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCCACTGTCGTGCAGCTCAG	0.398													19	90					0	0	0	0	A	179598042	A	A	179598042	2	1	34	1	0	0	0	0	0	0	0	1	16803	1136	40	1		1	TTN	2	179598042	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1035	179598042	63601331	87	6379											
TTN	7273	broad.mit.edu	37	chr2	179599474	179599474	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagctatcactgccgacGtcattcactgcttcacatga	9	11	7	14	2	4	1	4	1	0	0	4	2	4	1	1	0	4	3	1	0	1	3	rs74607159	by1000genomes	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:179599474G>T	uc010zfg.1	-	48	11669	c.11445C>A	c.(11443-11445)GAC>GAA	p.D3815E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D476E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4742							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGCCGACGTCATTCACTG	0.368													49	137					1.4709e-25	1.96387e-25	1	0	T	179599474	T	T	179599474	3	4	34	1	0	0	0	0	1	0	0	0	16803	1136	40	3	89600	3	TTN	2	179599474	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1432	179599474	63599899	88	6380											
TTN	7273	broad.mit.edu	37	chr2	179615464	179615464	+	Frame_Shift_Del	DEL	T	-	-																															tttcttcactttcttcaacaTttacaagtgtaccaaaagat																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:179615464delT	uc002unb.2	-	46	11887	c.11663delA	c.(11662-11664)AATfs	p.N3888fs	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTCAACATTTACAAGTGT	0.353													---	---	---								-	179615464	-	-	179615464	7	5	34	1	0	1	0	1	0	0	0	0	16803	1493	52	0	98634	0	TTN	2	179615464	Frame_Shift_Del	DEL	T	TCGA-BB-7871-01A-11D-2229-08	15990	179615464	63583909	89	6381											
TTN	7273	broad.mit.edu	37	chr2	179638712	179638712	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccctgtcactgggctgcaCttcttggccgtctttcatcc	5	13	8	15	1	4	0	2	0	2	0	5	0	5	0	3	2	2	2	3	2	1	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:179638712C>A	uc010zfg.1	-	31	7407	c.7183G>T	c.(7183-7185)GTG>TTG	p.V2395L	TTN_uc010zfh.1_Missense_Mutation_p.V2349L|TTN_uc010zfi.1_Missense_Mutation_p.V2349L|TTN_uc010zfj.1_Missense_Mutation_p.V2349L|TTN_uc002unb.2_Missense_Mutation_p.V2395L|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2395							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGGCTGCACTTCTTGGCCG	0.438													29	94					1.06801e-11	1.23718e-11	1	0	A	179638712	A	A	179638712	3	1	34	1	0	0	0	0	1	0	0	0	16803	565	20	4	104133	4	TTN	2	179638712	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	23248	179638712	63560661	90	6382											
ITGA4	3676	broad.mit.edu	37	chr2	182392025	182392025	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgaatttgtttttaccaggTttgtaaacccaacttcattt	10	19	5	7	0	1	1	1	1	0	0	1	1	1	1	2	1	3	3	2	1	5	9			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:182392025T>A	uc002unu.2	+	22	3104	c.2341T>A	c.(2341-2343)TTT>ATT	p.F781I	ITGA4_uc010frj.1_Missense_Mutation_p.F263I|ITGA4_uc002unv.2_Missense_Mutation_p.F26I	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	781	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TTTTACCAGGTTTGTAAACCC	0.308													12	34					0	0	0	0	A	182392025	A	A	182392025	3	1	34	1	0	0	0	0	1	0	0	0	7917	1739	60	5	2427	5	ITGA4	2	182392025	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	2753313	182392025	60807348	91	6383											
ZSWIM2	151112	broad.mit.edu	37	chr2	187698683	187698683	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatactgtacctcacgaaatGtaaacgtgtgggaaagatgg	14	9	12	6	2	1	1	1	0	0	1	1	4	1	2	1	2	3	2	1	2	6	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:187698683G>A	uc002upu.1	-	6	858	c.818C>T	c.(817-819)ACA>ATA	p.T273I		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	273	ZZ-type.				apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			CTCACGAAATGTAAACGTGTG	0.363													17	50					0	0	0	0	A	187698683	A	A	187698683	3	1	34	1	0	0	0	0	1	0	0	0	18308	1377	48	4	1099	4	ZSWIM2	2	187698683	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	5306658	187698683	55500690	92	6384											
COL5A2	1290	broad.mit.edu	37	chr2	189962026	189962026	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttccttttggccctcgctCtcctcttggtccctgtgatc	1	17	7	16	1	3	1	0	1	3	0	8	1	5	1	4	2	0	1	4	2	0	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:189962026C>A	uc002uqk.2	-	6	708	c.433G>T	c.(433-435)GAG>TAG	p.E145*		NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	145					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGCCCTCGCTCTCCTCTTGGT	0.428													21	49					2.79863e-10	3.14525e-10	1	0	A	189962026	A	A	189962026	4	1	34	1	0	0	0	0	0	1	0	0	3712	922	32	2	4262	2	COL5A2	2	189962026	Nonsense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2263343	189962026	53237347	93	6385											
SATB2	23314	broad.mit.edu	37	chr2	200246504	200246504	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgggtgcatctgtcacataaCtgagggggagagggttccac	9	8	15	9	1	2	2	1	1	1	1	3	3	3	2	1	4	2	2	1	4	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:200246504C>A	uc002uuy.1	-	4	1203	c.386G>T	c.(385-387)AGT>ATT	p.S129I	SATB2_uc010fsq.1_Intron|SATB2_uc002uuz.1_Missense_Mutation_p.S129I|SATB2_uc002uva.1_Missense_Mutation_p.S129I	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	129						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGTCACATAACTGAGGGGGAG	0.438													19	58					3.32936e-07	3.58546e-07	1	0	A	200246504	A	A	200246504	3	1	34	1	0	0	0	0	1	0	0	0	13919	565	20	4	1847	4	SATB2	2	200246504	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	10284478	200246504	42952869	94	6386											
PTH2R	5746	broad.mit.edu	37	chr2	209308252	209308252	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaggcaacttctgtggacaAatcacaatatgtaagtgttt	13	13	9	6	0	2	1	1	1	1	0	2	2	2	2	0	2	1	3	0	2	5	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:209308252A>G	uc002vdb.2	+	6	902	c.689A>G	c.(688-690)AAA>AGA	p.K230R	PTH2R_uc010zjb.1_Missense_Mutation_p.K241R	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	230	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TCTGTGGACAAATCACAATAT	0.363													17	65					0	0	0	0	G	209308252	G	G	209308252	3	3	34	1	0	0	0	0	1	0	0	0	12823	14	1	5	711	5	PTH2R	2	209308252	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	9061748	209308252	33891121	95	6387											
PRKAG3	53632	broad.mit.edu	37	chr2	219692034	219692034	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagtacgttgcctgacaccGggtcaagaacaggcaggcga	11	5	15	10	3	1	2	1	1	0	1	1	4	1	3	2	4	3	3	2	4	3	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:219692034G>A	uc002vjb.1	-	9	957	c.938C>T	c.(937-939)CCG>CTG	p.P313L	PRKAG3_uc010zkn.1_RNA|PRKAG3_uc010fvy.1_Missense_Mutation_p.R355W	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	313	CBS 2.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCTGACACCGGGTCAAGAAC	0.582													9	31					0	0	0	0	A	219692034	A	A	219692034	3	1	34	1	0	0	0	0	1	0	0	0	12564	1116	39	1	551	1	PRKAG3	2	219692034	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	10383782	219692034	23507339	96	6388											
CCDC108	255101	broad.mit.edu	37	chr2	219868777	219868777	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctcctgggactcaggctgtgGtgtgggcccgatgcccgccc	3	8	15	15	2	1	0	1	0	0	0	2	2	2	1	4	4	1	1	4	4	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:219868777G>T	uc002vjl.1	-	33	5536	c.5452C>A	c.(5452-5454)CCA>ACA	p.P1818T	uc010fvz.1_5'Flank|MIR375_hsa-mir-375|MI0000783_5'Flank	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	1818	Glu-rich.					integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAGGCTGTGGTGTGGGCCCG	0.383													75	270					3.54697e-40	4.97998e-40	1	0	T	219868777	T	T	219868777	3	4	34	1	0	0	0	0	1	0	0	0	2755	1261	44	4	337	4	CCDC108	2	219868777	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	176743	219868777	23330596	97	6389											
SPEG	10290	broad.mit.edu	37	chr2	220353896	220353896	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgccaaccgtgctgggcaggGgcccttcagcaactcttctg	6	9	12	14	1	3	0	1	0	2	0	3	0	3	0	3	3	5	3	3	3	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:220353896G>A	uc010fwg.2	+	35	8270	c.8270G>A	c.(8269-8271)GGG>GAG	p.G2757E		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2757	Fibronectin type-III 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCTGGGCAGGGGCCCTTCAGC	0.592													33	130					0	0	0	0	A	220353896	A	A	220353896	3	1	34	1	0	0	0	0	1	0	0	0	15102	1232	43	4	8420	4	SPEG	2	220353896	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	485119	220353896	22845477	98	6390											
TRIP12	9320	broad.mit.edu	37	chr2	230636255	230636255	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctccgggtagaagtactGaagatgactgagtgggaaga	12	9	14	6	1	0	6	0	3	0	3	2	7	2	7	2	2	1	2	2	2	5	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:230636255G>A	uc002vpw.1	-	38	5672	c.5563C>T	c.(5563-5565)CAG>TAG	p.Q1855*	TRIP12_uc002vpx.1_Nonsense_Mutation_p.Q1903*|TRIP12_uc002vpy.1_Nonsense_Mutation_p.Q1585*	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1855					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TAGAAGTACTGAAGATGACTG	0.408													12	48					0	0	0	0	A	230636255	A	A	230636255	4	1	34	1	0	0	0	0	0	1	0	0	16623	1299	45	2	431	2	TRIP12	2	230636255	Nonsense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	10282359	230636255	12563118	99	6391											
INPP5D	3635	broad.mit.edu	37	chr2	233986855	233986855	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgaggttcttcaccaagctGgaccagctcatcgagtttta	10	12	9	10	1	3	1	2	1	1	0	4	3	3	2	2	2	2	4	2	2	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:233986855G>A	uc010zmo.1	+	3	390	c.237G>A	c.(235-237)CTG>CTA	p.L79L	INPP5D_uc010zmp.1_Silent_p.L79L	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	79	SH2.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCACCAAGCTGGACCAGCTCA	0.522													24	77					0	0	0	0	A	233986855	A	A	233986855	2	1	34	1	0	0	0	0	0	0	0	1	7795	1335	47	4		4	INPP5D	2	233986855	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	3350600	233986855	9212518	100	6392											
COL6A3	1293	broad.mit.edu	37	chr2	238267208	238267208	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctctttctcctttctctcCtcgaggtcctttatcaccct	3	18	3	17	1	4	0	1	0	3	0	10	1	7	0	5	1	0	0	5	1	1	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:238267208C>A	uc002vwl.2	-	21	6712	c.6427G>T	c.(6427-6429)GGA>TGA	p.G2143*	COL6A3_uc002vwo.2_Nonsense_Mutation_p.G1937*|COL6A3_uc010znj.1_Nonsense_Mutation_p.G1536*|COL6A3_uc002vwp.1_5'Flank	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2143	Triple-helical region.|Collagen-like 2.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCTTTCTCTCCTCGAGGTCCT	0.423													35	69					3.54909e-21	4.60067e-21	1	0	A	238267208	A	A	238267208	4	1	34	1	0	0	0	0	0	1	0	0	3716	690	24	4	3202	4	COL6A3	2	238267208	Nonsense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	4280353	238267208	4932165	101	6393											
ING5	84289	broad.mit.edu	37	chr2	242644114	242644114	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggaacttccagctgatGcgagagctggaccagaggac	12	5	14	10	1	0	4	0	1	0	3	1	8	1	7	2	3	4	2	2	3	1	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr2:242644114G>T	uc002wcd.2	+	2	109	c.84G>T	c.(82-84)ATG>ATT	p.M28I	ING5_uc002wcc.1_Missense_Mutation_p.M28I	NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	28					DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		TCCAGCTGATGCGAGAGCTGG	0.532													26	113					2.29764e-31	3.17139e-31	1	0	T	242644114	T	T	242644114	3	4	34	1	0	0	0	0	1	0	0	0	7778	1319	46	4	90	4	ING5	2	242644114	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	4376906	242644114	555259	102	6394											
SETD5	55209	broad.mit.edu	37	chr3	9486800	9486800	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatacaaaaaaggaatcctaAtgctacagaactgccactcc	17	8	5	11	0	0	1	0	0	0	1	2	2	2	2	3	1	5	1	3	1	9	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:9486800A>C	uc003brt.2	+	12	1691	c.1256A>C	c.(1255-1257)AAT>ACT	p.N419T	SETD5_uc003brs.1_Missense_Mutation_p.N400T|SETD5_uc003bru.2_Missense_Mutation_p.N321T|SETD5_uc003brv.2_Missense_Mutation_p.N308T|SETD5_uc010hck.2_5'UTR|SETD5_uc003brw.1_Missense_Mutation_p.N88T|SETD5_uc003brx.2_Missense_Mutation_p.N88T	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	419										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGGAATCCTAATGCTACAGAA	0.463													16	32					0	0	0	0	C	9486800	C	C	9486800	3	2	34	1	0	0	0	0	1	0	0	0	14199	101	4	5	1294	5	SETD5	3	9486800	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08		9486800	188535630	103	6395											
SCN5A	6331	broad.mit.edu	37	chr3	38622704	38622704	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgctgccgcaggagaccAcagcagaaatcccaggtggt	10	4	14	13	2	0	2	0	0	0	2	1	3	1	2	4	4	2	3	4	4	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:38622704A>G	uc003cio.2	-	17	3140	c.2946T>C	c.(2944-2946)TGT>TGC	p.C982C	SCN5A_uc003cin.2_Silent_p.C982C|SCN5A_uc003cil.3_Silent_p.C982C|SCN5A_uc010hhi.2_Silent_p.C982C|SCN5A_uc010hhk.2_Silent_p.C982C|SCN5A_uc011ayr.1_Silent_p.C982C|SCN5A_uc010hhj.1_Silent_p.C593C	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	982					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GCAGGAGACCACAGCAGAAAT	0.672													2	4					0	0	0	0	G	38622704	G	G	38622704	2	3	34	1	0	0	0	0	0	0	0	1	13987	157	6	5		5	SCN5A	3	38622704	Silent	SNP	A	TCGA-BB-7871-01A-11D-2229-08	29135904	38622704	159399726	104	6396											
LRRC2	79442	broad.mit.edu	37	chr3	46586628	46586628	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgccttgtgagagtgttccTttcaatcttgtccagaagcc	7	14	9	11	0	2	2	1	1	1	2	4	3	4	2	4	0	2	1	4	0	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:46586628T>C	uc010hji.2	-	3	605	c.241A>G	c.(241-243)AGG>GGG	p.R81G	LRRC2_uc003cpu.3_Missense_Mutation_p.R81G	NM_024512	NP_078788	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	81										ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		AGAGTGTTCCTTTCAATCTTG	0.532													69	180					0	0	0	0	C	46586628	C	C	46586628	3	2	34	1	0	0	0	0	1	0	0	0	9026	1608	56	5	902	5	LRRC2	3	46586628	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	7963924	46586628	151435802	105	6397											
COL7A1	1294	broad.mit.edu	37	chr3	48615932	48615932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggaggccctgttctccaCggaggcctggaagcccctgg	6	6	15	14	1	1	0	0	0	1	0	2	3	1	3	5	6	1	1	5	6	1	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:48615932C>T	uc003ctz.2	-	63	5442	c.5441G>A	c.(5440-5442)CGT>CAT	p.R1814H		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1814	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGTTCTCCACGGAGGCCTGG	0.552													30	71					0	0	0	0	T	48615932	T	T	48615932	3	4	34	1	0	0	0	0	1	0	0	0	3719	536	19	1	3617	1	COL7A1	3	48615932	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2029304	48615932	149406498	106	6398											
CELSR3	1951	broad.mit.edu	37	chr3	48687962	48687962	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaggacgccaaactttgtCtggggccaccacacaccaga	11	5	10	15	1	1	1	0	0	1	1	1	2	1	2	5	3	1	0	5	3	1	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:48687962C>T	uc003cul.2	-	16	6704	c.6423G>A	c.(6421-6423)CAG>CAA	p.Q2141Q	CELSR3_uc003cuf.1_Silent_p.Q2211Q|CELSR3_uc010hkg.2_Silent_p.Q119Q	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2141	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CAAACTTTGTCTGGGGCCACC	0.617													6	18					0	0	0	0	T	48687962	T	T	48687962	2	4	34	1	0	0	0	0	0	0	0	1	3238	912	32	2		2	CELSR3	3	48687962	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	72030	48687962	149334468	107	6399											
CELSR3	1951	broad.mit.edu	37	chr3	48688839	48688839	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgcagttgggatcaaaacCtttgtgaacatcacagttgc	11	12	10	8	0	2	1	2	1	0	0	2	2	2	2	1	1	4	4	1	1	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:48688839C>G	uc003cul.2	-	14	6420	c.6139G>C	c.(6139-6141)GGT>CGT	p.G2047R	CELSR3_uc003cuf.1_Missense_Mutation_p.G2117R|CELSR3_uc010hkg.2_Missense_Mutation_p.G25R	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2047	Extracellular (Potential).|EGF-like 7; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGATCAAAACCTTTGTGAACA	0.577													26	61					0	0	0	0	G	48688839	G	G	48688839	3	3	34	1	0	0	0	0	1	0	0	0	3238	681	24	4	3887	4	CELSR3	3	48688839	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	877	48688839	149333591	108	6400											
CELSR3	1951	broad.mit.edu	37	chr3	48689419	48689419	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacagccaggctccgcattCactcggtggctggggggtag	7	7	15	12	2	1	0	1	0	0	0	3	0	2	0	2	6	1	4	2	6	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:48689419C>T	uc003cul.2	-	12	6095	c.5814G>A	c.(5812-5814)GTG>GTA	p.V1938V	CELSR3_uc003cuf.1_Silent_p.V2008V|CELSR3_uc010hkg.2_5'UTR	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1938	Extracellular (Potential).|Laminin G-like 2.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTCCGCATTCACTCGGTGGC	0.652													17	32					0	0	0	0	T	48689419	T	T	48689419	2	4	34	1	0	0	0	0	0	0	0	1	3238	813	29	2		2	CELSR3	3	48689419	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	580	48689419	149333011	109	6401											
RBM5	10181	broad.mit.edu	37	chr3	50127886	50127886	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caatgggttcagacaaaaggTaagttactacagtacgtggc	14	9	11	7	1	1	1	1	0	0	1	1	1	1	1	0	3	3	4	0	3	7	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:50127886T>G	uc003cyg.2	+	2	165	c.17_splice	c.e2+2	p.R6_splice	RBM6_uc010hld.1_Splice_Site|RBM6_uc010hle.1_Splice_Site|RBM6_uc010hlf.1_Splice_Site|RBM5_uc003cyf.2_Splice_Site_p.R6_splice|RBM5_uc011bdj.1_Splice_Site|RBM5_uc011bdk.1_Splice_Site	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5						apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGACAAAAGGTAAGTTACTAC	0.358													32	51					0	0	0	0	G	50127886	G	G	50127886	5	3	34	1	0	0	0	0	0	0	1	0	13208	1652	57	5	21	5	RBM5	3	50127886	Splice_Site	SNP	T	TCGA-BB-7871-01A-11D-2229-08	1438467	50127886	147894544	110	6402											
VPRBP	9730	broad.mit.edu	37	chr3	51450781	51450781	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgttcggaaggatgaccCaaaggggcttttcatcctct	11	11	10	9	1	2	1	1	1	1	0	4	3	3	3	2	4	0	2	2	4	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:51450781C>G	uc003dbe.1	-	20	4159	c.3991G>C	c.(3991-3993)GGG>CGG	p.G1331R	VPRBP_uc003dbf.1_Missense_Mutation_p.G607R	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	1331					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		AAGGATGACCCAAAGGGGCTT	0.428													10	17					0	0	0	0	G	51450781	G	G	51450781	3	3	34	1	0	0	0	0	1	0	0	0	17253	594	21	4	552	4	VPRBP	3	51450781	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1322895	51450781	146571649	111	6403											
PBRM1	55193	broad.mit.edu	37	chr3	52662995	52662995	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggcattttcaaacattaaaTtcagatcacactccaaatga	16	12	4	9	0	3	2	3	1	0	1	4	2	4	2	1	1	1	1	1	1	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:52662995T>C	uc003des.2	-	12	1370	c.1358A>G	c.(1357-1359)AAT>AGT	p.N453S	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.N453S|PBRM1_uc003der.2_Missense_Mutation_p.N421S|PBRM1_uc003det.2_Missense_Mutation_p.N453S|PBRM1_uc003deu.2_Missense_Mutation_p.N453S|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.N453S|PBRM1_uc010hmk.1_Missense_Mutation_p.N453S|PBRM1_uc003dey.2_Missense_Mutation_p.N453S|PBRM1_uc003dez.1_Missense_Mutation_p.N453S|PBRM1_uc003dfb.1_Missense_Mutation_p.N351S	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	453	Bromo 3.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AAACATTAAATTCAGATCACA	0.328			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								26	35					0	0	0	0	C	52662995	C	C	52662995	3	2	34	1	0	0	0	0	1	0	0	0	11545	1493	52	5	3618	5	PBRM1	3	52662995	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	1212214	52662995	145359435	112	6404											
PRKCD	5580	broad.mit.edu	37	chr3	53217541	53217541	+	Frame_Shift_Del	DEL	G	-	-																															ctacatgagccccaccttctGtgaccactgcggcagcctgc																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:53217541delG	uc003dgl.2	+	9	1084	c.731delG	c.(730-732)TGTfs	p.C244fs	PRKCD_uc003dgm.2_Frame_Shift_Del_p.C244fs|PRKCD_uc010hmt.1_Frame_Shift_Del_p.C16fs	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	244	Phorbol-ester/DAG-type 2.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		CCCACCTTCTGTGACCACTGC	0.602													---	---	---								-	53217541	-	-	53217541	7	5	34	1	0	1	0	1	0	0	0	0	12571	1377	48	0	757	0	PRKCD	3	53217541	Frame_Shift_Del	DEL	G	TCGA-BB-7871-01A-11D-2229-08	554546	53217541	144804889	113	6405											
FILIP1L	11259	broad.mit.edu	37	chr3	99567462	99567462	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actgatttctgttggttctgGggagcgtccctgctcaggag	5	13	14	9	1	3	1	1	1	2	0	4	3	4	3	1	4	2	3	1	4	0	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:99567462G>T	uc003dtm.2	-	5	3521	c.3058C>A	c.(3058-3060)CCA>ACA	p.P1020T	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Missense_Mutation_p.P1020T|FILIP1L_uc010hpf.2_Missense_Mutation_p.P596T|FILIP1L_uc010hpg.2_Missense_Mutation_p.P780T|FILIP1L_uc003dtn.2_Missense_Mutation_p.P780T|FILIP1L_uc003dtp.1_Missense_Mutation_p.P780T	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	1020						cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						GTTGGTTCTGGGGAGCGTCCC	0.512													38	174					1.04594e-18	1.31413e-18	1	0	T	99567462	T	T	99567462	3	4	34	1	0	0	0	0	1	0	0	0	5927	1232	43	4	378	4	FILIP1L	3	99567462	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	46349921	99567462	98454968	114	6406											
ZBTB11	27107	broad.mit.edu	37	chr3	101384101	101384101	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgagctactaattacattctCttttgaaagtttagggtgta	11	16	8	6	1	1	1	0	1	1	0	2	2	1	1	0	1	3	3	0	1	6	9			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:101384101C>T	uc003dve.3	-	4	1560	c.1330G>A	c.(1330-1332)GAG>AAG	p.E444K		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	444					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATTACATTCTCTTTTGAAAGT	0.348													52	181					0	0	0	0	T	101384101	T	T	101384101	3	4	34	1	0	0	0	0	1	0	0	0	17591	922	32	2	1863	2	ZBTB11	3	101384101	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1816639	101384101	96638329	115	6407											
TMPRSS7	344805	broad.mit.edu	37	chr3	111797614	111797614	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaggctccctcgttctgcaGcaagcggaggtagagctcat	10	8	12	11	2	2	1	1	0	1	1	4	2	3	2	1	3	4	6	1	3	3	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:111797614G>A	uc010hqb.2	+	15	2042	c.1872G>A	c.(1870-1872)CAG>CAA	p.Q624Q	TMPRSS7_uc011bhr.1_Silent_p.Q479Q	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	750	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						TCGTTCTGCAGCAAGCGGAGG	0.413													23	92					0	0	0	0	A	111797614	A	A	111797614	2	1	34	1	0	0	0	0	0	0	0	1	16318	962	34	4		4	TMPRSS7	3	111797614	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	10413513	111797614	86224816	116	6408											
HGD	3081	broad.mit.edu	37	chr3	120363269	120363269	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggtatcaagaaatcacgaGgattggccaagccattggcc	12	8	12	9	1	2	1	2	0	0	1	2	3	2	2	3	4	1	1	3	4	4	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:120363269G>C	uc003edw.2	-	10	1041	c.671C>G	c.(670-672)CCT>CGT	p.P224R	HGD_uc003edv.2_Missense_Mutation_p.P83R	NM_000187	NP_000178	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	224					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding				0				GBM - Glioblastoma multiforme(114;0.158)		GAAATCACGAGGATTGGCCAA	0.448													30	70					0	0	0	0	C	120363269	C	C	120363269	3	2	34	1	0	0	0	0	1	0	0	0	7123	1000	35	4	686	4	HGD	3	120363269	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	8565655	120363269	77659161	117	6409											
GOLGB1	2804	broad.mit.edu	37	chr3	121386956	121386956	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggtcactctttctgtgaactCcattcttttcctggggagct	5	16	9	11	0	4	1	1	1	3	0	6	2	6	2	2	3	2	1	2	3	1	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:121386956C>G	uc003eei.3	-	19	9482	c.9356G>C	c.(9355-9357)GGA>GCA	p.G3119A	GOLGB1_uc010hrc.2_Missense_Mutation_p.G3129A|GOLGB1_uc003eej.3_Missense_Mutation_p.G3085A	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	3119	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCTGTGAACTCCATTCTTTTC	0.463													44	34					0	0	0	0	G	121386956	G	G	121386956	3	3	34	1	0	0	0	0	1	0	0	0	6602	855	30	2	439	2	GOLGB1	3	121386956	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1023687	121386956	76635474	118	6410											
ADCY5	111	broad.mit.edu	37	chr3	123023004	123023004	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaccgcacgatcttcctggaGagggtctgcagtggggaggg	7	7	18	9	2	2	1	0	0	2	1	3	5	3	2	2	5	1	2	2	5	0	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:123023004G>C	uc003egh.1	-	13	2469	c.2469C>G	c.(2467-2469)CTC>CTG	p.L823L	ADCY5_uc003egg.1_Silent_p.L456L|ADCY5_uc003egi.1_Silent_p.L382L	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	823					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TCTTCCTGGAGAGGGTCTGCA	0.393													16	88					0	0	0	0	C	123023004	C	C	123023004	2	2	34	1	0	0	0	0	0	0	0	1	297	929	33	2		2	ADCY5	3	123023004	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1636048	123023004	74999426	119	6411											
A4GNT	51146	broad.mit.edu	37	chr3	137843704	137843704	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgtggagccagtttctcTctgcgctggcgttgatctgc	4	14	13	10	2	3	2	0	2	3	0	4	3	3	3	1	2	3	3	1	2	0	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:137843704T>A	uc003ers.2	-	3	627	c.425A>T	c.(424-426)GAG>GTG	p.E142V		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	142	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						CCAGTTTCTCTCTGCGCTGGC	0.597													42	73					0	0	0	0	A	137843704	A	A	137843704	3	1	34	1	0	0	0	0	1	0	0	0	7	1551	54	5	601	5	A4GNT	3	137843704	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	14820700	137843704	60178726	120	6412											
AGTR1	185	broad.mit.edu	37	chr3	148459701	148459701	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accatttgtatagcttatttTaacaattgcctgaatcctct	11	17	4	9	0	1	1	0	1	1	0	2	1	2	1	3	0	3	2	3	0	6	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:148459701T>A	uc003ewg.2	+	4	1325	c.879T>A	c.(877-879)TTT>TTA	p.F293L	AGTR1_uc003ewh.2_Missense_Mutation_p.F293L|AGTR1_uc003ewi.2_Missense_Mutation_p.F293L|AGTR1_uc003ewj.2_Missense_Mutation_p.F293L|AGTR1_uc003ewk.2_Missense_Mutation_p.F293L	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	293	Helical; Name=7; (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	TAGCTTATTTTAACAATTGCC	0.363													85	71					0	0	0	0	A	148459701	A	A	148459701	3	1	34	1	0	0	0	0	1	0	0	0	401	1751	61	5	881	5	AGTR1	3	148459701	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	10615997	148459701	49562729	121	6413											
P2RY13	53829	broad.mit.edu	37	chr3	151046465	151046465	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcacgatgcccacatacaTggtctcataaaatatcaccg	14	8	6	13	2	2	0	2	0	1	0	3	1	2	0	2	1	3	1	2	1	4	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:151046465T>A	uc003eyv.2	-	2	400	c.379A>T	c.(379-381)ATG>TTG	p.M127L	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	127	Helical; Name=3; (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			CCCACATACATGGTCTCATAA	0.423													22	104					0	0	0	0	A	151046465	A	A	151046465	3	1	34	1	0	0	0	0	1	0	0	0	11404	1464	51	5	689	5	P2RY13	3	151046465	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	2586764	151046465	46975965	122	6414											
SI	6476	broad.mit.edu	37	chr3	164709191	164709191	+	Frame_Shift_Del	DEL	A	-	-																															catggtaggatgtgaccaccAcggacatgtaggtttattgt																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:164709191delA	uc003fei.2	-	44	5120	c.5058delT	c.(5056-5058)CGTfs	p.R1686fs		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1686	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGTGACCACCACGGACATGTA	0.393										HNSCC(35;0.089)			---	---	---								-	164709191	-	-	164709191	7	5	34	1	0	1	0	1	0	0	0	0	14362	146	6	0	445	0	SI	3	164709191	Frame_Shift_Del	DEL	A	TCGA-BB-7871-01A-11D-2229-08	13662726	164709191	33313239	123	6415											
SI	6476	broad.mit.edu	37	chr3	164737429	164737430	+	Missense_Mutation	DNP	CC	AA	AA																															gtgaacattccccaagtattCcagttcagatctcgcttaaa																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:164737429_164737430CC>AA	uc003fei.2	-	28	3445_3446	c.3383_3384GG>TT	c.(3382-3384)TGG>TTT	p.W1128F		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1128	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CCCAAGTATTCCAGTTCAGATC	0.436										HNSCC(35;0.089)			74	53					0	0	0	0	AA	164737430	AA	AA	164737429	3	1	34	1	0	0	0	0	1	0	0	0	14362	856	30	2	2183	2	SI	3	164737429	Missense_Mutation	DNP	CC	TCGA-BB-7871-01A-11D-2229-08	28238	164737429	33285001	124	6416											
SI	6476	broad.mit.edu	37	chr3	164754255	164754255	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcgactataagtcctagagGattcttacggctgttaagaa	12	12	10	7	2	1	2	0	0	1	2	2	4	2	3	1	2	2	2	1	2	6	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr3:164754255G>A	uc003fei.2	-	22	2499	c.2437C>T	c.(2437-2439)CCT>TCT	p.P813S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	813	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AGTCCTAGAGGATTCTTACGG	0.348										HNSCC(35;0.089)			38	88					0	0	0	0	A	164754255	A	A	164754255	3	1	34	1	0	0	0	0	1	0	0	0	14362	1174	41	2	3154	2	SI	3	164754255	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	16826	164754255	33268175	125	6417											
KIAA1530	57654	broad.mit.edu	37	chr4	1343557	1343557	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgaggcaggcgaccacccGggccgtggaagggtggaatg	8	4	19	10	3	0	1	0	1	0	0	0	4	0	3	3	6	0	2	3	6	2	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr4:1343557G>T	uc003gde.3	+	3	791	c.344G>T	c.(343-345)CGG>CTG	p.R115L		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	115											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			GCGACCACCCGGGCCGTGGAA	0.622													8	21					4.68919e-08	5.1288e-08	1	0	T	1343557	T	T	1343557	3	4	34	1	0	0	0	0	1	0	0	0	8280	1116	39	3	350	3	KIAA1530	4	1343557	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08		1343557	189810719	126	6418											
DCAF4L1	285429	broad.mit.edu	37	chr4	41984475	41984475	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggacaccagcagtcatttgaTaccagcagtgatgtcttggc	10	10	11	10	0	2	2	1	2	1	0	2	3	2	3	2	2	3	2	2	2	1	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr4:41984475T>C	uc003gwk.2	+	1	763	c.666T>C	c.(664-666)GAT>GAC	p.D222D		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	222										skin(1)	1						AGTCATTTGATACCAGCAGTG	0.547													45	215					0	0	0	0	C	41984475	C	C	41984475	2	2	34	1	0	0	0	0	0	0	0	1	4288	1403	49	5		5	DCAF4L1	4	41984475	Silent	SNP	T	TCGA-BB-7871-01A-11D-2229-08	40640918	41984475	149169801	127	6419											
KIAA1211	57482	broad.mit.edu	37	chr4	57182085	57182085	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcccaagccttccttaccCtccgcagaaagtggtggccc	7	9	9	16	1	0	1	0	0	0	1	3	1	3	1	6	2	2	1	6	2	3	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr4:57182085C>T	uc003hbk.2	+	8	2808	c.2417C>T	c.(2416-2418)CCT>CTT	p.P806L	KIAA1211_uc010iha.2_Missense_Mutation_p.P799L|KIAA1211_uc011bzz.1_Missense_Mutation_p.P716L|KIAA1211_uc003hbm.1_Missense_Mutation_p.P692L	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	806										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CTTCCTTACCCTCCGCAGAAA	0.592													16	56					0	0	0	0	T	57182085	T	T	57182085	3	4	34	1	0	0	0	0	1	0	0	0	8254	681	24	4	2435	4	KIAA1211	4	57182085	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	15197610	57182085	133972191	128	6420											
EREG	2069	broad.mit.edu	37	chr4	75231040	75231040	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcgccgatgaccgcggggagGaggatggagatgctctgtgc	7	7	18	9	4	1	2	0	1	1	1	2	7	1	5	2	5	2	1	2	5	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr4:75231040G>A	uc003hie.1	+	1	181	c.15G>A	c.(13-15)AGG>AGA	p.R5R	EREG_uc003hid.2_5'UTR	NM_001432	NP_001423	O14944	EREG_HUMAN	epiregulin preproprotein	5					angiogenesis|cell-cell signaling|cytokine-mediated signaling pathway|epidermal growth factor receptor signaling pathway|female meiosis|keratinocyte differentiation|keratinocyte proliferation|luteinizing hormone signaling pathway|mRNA transcription|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|negative regulation of transcription, DNA-dependent|oocyte maturation|organ morphogenesis|ovarian cumulus expansion|ovulation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor activity|positive regulation of fibroblast proliferation|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of mitosis|positive regulation of phosphorylation|positive regulation of smooth muscle cell proliferation|primary follicle stage|wound healing	extracellular space|integral to plasma membrane	epidermal growth factor receptor binding|growth factor activity			breast(1)|skin(1)	2			Lung(101;0.196)			CCGCGGGGAGGAGGATGGAGA	0.706													11	38					0	0	0	0	A	75231040	A	A	75231040	2	1	34	1	0	0	0	0	0	0	0	1	5244	1165	41	2		2	EREG	4	75231040	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	18048955	75231040	115923236	129	6421											
GK2	2712	broad.mit.edu	37	chr4	80327926	80327926	+	Frame_Shift_Del	DEL	G	-	-																															cctgagaactgacaaagcctGgggttcaaggctccaaacgc																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr4:80327926delG	uc003hlu.2	-	1	1447	c.1429delC	c.(1429-1431)CAGfs	p.Q477fs		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	477					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						GACAAAGCCTGGGGTTCAAGG	0.483													---	---	---								-	80327926	-	-	80327926	7	5	34	1	0	1	0	1	0	0	0	0	6458	1357	47	0	236	0	GK2	4	80327926	Frame_Shift_Del	DEL	G	TCGA-BB-7871-01A-11D-2229-08	5096886	80327926	110826350	130	6422											
GAR1	54433	broad.mit.edu	37	chr4	110737454	110737454	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cggcaatttcagaggcggcgGcaggggaggatttggacgag	9	6	19	7	4	1	1	1	0	0	1	1	5	1	4	0	8	0	2	0	8	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr4:110737454G>T	uc003hzt.2	+	2	441	c.134G>T	c.(133-135)GGC>GTC	p.G45V	GAR1_uc003hzu.2_Missense_Mutation_p.G45V|GAR1_uc010imh.1_Missense_Mutation_p.G45V|GAR1_uc010imi.2_Missense_Mutation_p.G45V	NM_018983	NP_061856	Q9NY12	GAR1_HUMAN	nucleolar protein family A, member 1	45	RGG-box 1.				rRNA processing|snRNA pseudouridine synthesis	box H/ACA snoRNP complex|Cajal body	cation channel activity|pseudouridine synthase activity|snoRNA binding				0						agaggcggcggcaggggaggA	0.244													21	40					6.33239e-15	7.69943e-15	1	0	T	110737454	T	T	110737454	3	4	34	1	0	0	0	0	1	0	0	0	6275	1203	42	4	136	4	GAR1	4	110737454	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	30409528	110737454	80416822	131	6423											
FAT4	79633	broad.mit.edu	37	chr4	126411357	126411357	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccagactcgcacacgggaagGacctgtgagatggtggtggc	9	6	16	10	2	0	2	0	1	0	2	1	5	0	4	2	5	0	1	2	5	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr4:126411357G>C	uc003ifj.3	+	17	13380	c.13380G>C	c.(13378-13380)AGG>AGC	p.R4460S	FAT4_uc011cgp.1_Missense_Mutation_p.R2701S|FAT4_uc003ifi.1_Missense_Mutation_p.R1937S	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4460	EGF-like 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACACGGGAAGGACCTGTGAGA	0.627													26	75					0	0	0	0	C	126411357	C	C	126411357	3	2	34	1	0	0	0	0	1	0	0	0	5724	1165	41	2	13446	2	FAT4	4	126411357	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	15673903	126411357	64742919	132	6424											
SPOCK3	50859	broad.mit.edu	37	chr4	167983653	167983653	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agattcttaccctgatcgaaGggttttcctggactccaagt	9	13	9	10	1	1	2	0	1	1	1	4	4	3	3	3	2	1	1	3	2	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr4:167983653G>T	uc003iri.1	-	4	375	c.234C>A	c.(232-234)CCC>CCA	p.P78P	SPOCK3_uc011cjp.1_Silent_p.P75P|SPOCK3_uc011cjq.1_Silent_p.P87P|SPOCK3_uc011cjr.1_5'UTR|SPOCK3_uc003irj.1_Silent_p.P75P|SPOCK3_uc011cjs.1_Silent_p.P27P|SPOCK3_uc011cjt.1_Intron|SPOCK3_uc011cju.1_Intron|SPOCK3_uc011cjv.1_Intron|SPOCK3_uc003irk.3_Silent_p.P75P|SPOCK3_uc011cjw.1_RNA	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	78					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		CCTGATCGAAGGGTTTTCCTG	0.323													24	36					4.7796e-09	5.32274e-09	1	0	T	167983653	T	T	167983653	2	4	34	1	0	0	0	0	0	0	0	1	15147	987	35	4		4	SPOCK3	4	167983653	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	41572296	167983653	23170623	133	6425											
TERT	7015	broad.mit.edu	37	chr5	1282690	1282690	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccagtgcaggaacttggcCaggatctcctcacgcagacg	10	6	12	13	2	2	1	1	0	1	1	3	3	2	3	3	3	3	2	3	3	1	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:1282690C>A	uc003jcb.1	-	3	1681	c.1623G>T	c.(1621-1623)CTG>CTT	p.L541L	TERT_uc003jbz.1_5'UTR|TERT_uc003jca.1_Silent_p.L541L|TERT_uc003jcc.1_Silent_p.L541L|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	541	RNA-interacting domain 2.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGAACTTGGCCAGGATCTCCT	0.547									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				10	21					7.03913e-09	7.78594e-09	1	0	A	1282690	A	A	1282690	2	1	34	1	0	0	0	0	0	0	0	1	15830	581	21	4		4	TERT	5	1282690	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08		1282690	179632570	134	6426											
ADCY2	108	broad.mit.edu	37	chr5	7773198	7773198	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtcctgggcgactacagcCaggtcttatttgagaggtga	9	10	13	9	2	1	2	0	2	1	1	2	4	2	2	2	3	2	0	2	3	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:7773198C>A	uc003jdz.1	+	18	2435	c.2368C>A	c.(2368-2370)CAG>AAG	p.Q790K	ADCY2_uc011cmo.1_Missense_Mutation_p.Q610K	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	790					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CGACTACAGCCAGGTCTTATT	0.502													17	58					1.01871e-10	1.15816e-10	1	0	A	7773198	A	A	7773198	3	1	34	1	0	0	0	0	1	0	0	0	294	595	21	4	2438	4	ADCY2	5	7773198	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	6490508	7773198	173142062	135	6427											
PRDM9	56979	broad.mit.edu	37	chr5	23524457	23524457	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccccaggtatgtgaactgtgCccgggatgatgaagagcaga	11	7	14	9	1	0	5	0	3	0	2	0	6	0	6	3	2	3	2	3	2	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:23524457C>A	uc003jgo.2	+	10	1147	c.965C>A	c.(964-966)GCC>GAC	p.A322D		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	322	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GTGAACTGTGCCCGGGATGAT	0.537										HNSCC(3;0.000094)			17	48					4.35082e-09	4.85626e-09	1	0	A	23524457	A	A	23524457	3	1	34	1	0	0	0	0	1	0	0	0	12525	739	26	4	999	4	PRDM9	5	23524457	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	15751259	23524457	157390803	136	6428											
ZFR	51663	broad.mit.edu	37	chr5	32390394	32390394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactcactgcaggcccctgaGgctgaggaggcatgcctggt	7	7	14	13	0	1	2	1	2	0	0	1	3	1	3	3	5	2	3	3	5	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:32390394G>A	uc003jhr.1	-	12	2209	c.2129C>T	c.(2128-2130)CCT>CTT	p.P710L	ZFR_uc011cny.1_5'Flank	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	710					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		AGGCCCCTGAGGCTGAGGAGG	0.532													27	99					0	0	0	0	A	32390394	A	A	32390394	3	1	34	1	0	0	0	0	1	0	0	0	17726	1000	35	4	1131	4	ZFR	5	32390394	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	8865937	32390394	148524866	137	6429											
ELOVL7	79993	broad.mit.edu	37	chr5	60063670	60063670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaaagctgtgggtgaccGtgaatagtcaacaatgtcac	12	9	10	10	1	3	2	3	2	0	0	3	2	3	2	2	1	2	1	2	1	5	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:60063670G>A	uc003jsi.3	-	5	516	c.316C>T	c.(316-318)CGG>TGG	p.R106W	ELOVL7_uc011cqo.1_Missense_Mutation_p.R19W|ELOVL7_uc010iwk.2_Missense_Mutation_p.R106W|ELOVL7_uc003jsj.3_Missense_Mutation_p.R93W	NM_024930	NP_079206	A1L3X0	ELOV7_HUMAN	elongation of very long chain fatty acids-like	106					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				GTGGGTGACCGTGAATAGTCA	0.363													17	43					0	0	0	0	A	60063670	A	A	60063670	3	1	34	1	0	0	0	0	1	0	0	0	5103	1144	40	1	549	1	ELOVL7	5	60063670	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	27673276	60063670	120851590	138	6430											
MAST4	375449	broad.mit.edu	37	chr5	66458461	66458461	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atctcttttcaaaaagctagCcaagcagccttctcctttac	11	13	4	13	0	3	0	1	0	2	0	5	0	3	0	3	0	5	2	3	0	5	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:66458461C>G	uc003jut.1	+	27	3313	c.3245C>G	c.(3244-3246)GCC>GGC	p.A1082G	MAST4_uc003juw.2_Missense_Mutation_p.A1010G	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1274						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AAAAAGCTAGCCAAGCAGCCT	0.473													13	36					0	0	0	0	G	66458461	G	G	66458461	3	3	34	1	0	0	0	0	1	0	0	0	9380	739	26	4	4052	4	MAST4	5	66458461	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	6394791	66458461	114456799	139	6431											
MTX3	345778	broad.mit.edu	37	chr5	79281439	79281439	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttacaagttgtgtgagtttCtgcagatttgcatctaccgt	8	17	9	7	1	2	2	0	1	2	1	2	2	2	2	1	0	4	4	1	0	3	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:79281439C>G	uc010jag.2	-	8	810	c.783G>C	c.(781-783)CAG>CAC	p.Q261H	MTX3_uc010jah.2_Intron|MTX3_uc003kge.3_Missense_Mutation_p.Q200H	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	261					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		GTGTGAGTTTCTGCAGATTTG	0.373													8	11					0	0	0	0	G	79281439	G	G	79281439	3	3	34	1	0	0	0	0	1	0	0	0	10022	912	32	2	163	2	MTX3	5	79281439	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	12822978	79281439	101633821	140	6432											
MSH3	4437	broad.mit.edu	37	chr5	80109506	80109506	+	Frame_Shift_Del	DEL	C	-	-																															catcatggctcagattggctCctatgttcctgcagaagaag																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:80109506delC	uc003kgz.2	+	20	3012	c.2759delC	c.(2758-2760)TCCfs	p.S920fs		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	920					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		CAGATTGGCTCCTATGTTCCT	0.398								MMR					---	---	---								-	80109506	-	-	80109506	7	5	34	1	0	1	0	1	0	0	0	0	9924	855	30	0	2837	0	MSH3	5	80109506	Frame_Shift_Del	DEL	C	TCGA-BB-7871-01A-11D-2229-08	828067	80109506	100805754	141	6433											
VCAN	1462	broad.mit.edu	37	chr5	82843903	82843903	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggtgcactttgtgagcaaGgtaagagctattgcaacatt	11	13	11	6	0	0	2	0	1	0	1	0	2	0	2	0	2	5	5	0	2	4	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:82843903G>A	uc003kii.3	+	10	9849	c.9493G>A	c.(9493-9495)GAT>AAT	p.D3165N	VCAN_uc003kij.3_Missense_Mutation_p.D2178N|VCAN_uc010jau.2_Missense_Mutation_p.D1411N|VCAN_uc003kik.3_Missense_Mutation_p.D424N|VCAN_uc003kil.3_Missense_Mutation_p.D1829N	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	3165					cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTGTGAGCAAGGTAAGAGCTA	0.383													13	30					0	0	0	0	A	82843903	A	A	82843903	3	1	34	1	0	0	0	0	1	0	0	0	17206	1014	35	4	9527	4	VCAN	5	82843903	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2734397	82843903	98071357	142	6434											
GPR98	84059	broad.mit.edu	37	chr5	90106265	90106265	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgttcagaatggggaacTgttttttcaaaaattccaaa	13	13	8	7	0	2	1	2	0	0	1	3	2	3	2	2	2	1	2	2	2	5	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:90106265T>A	uc003kju.2	+	74	15284	c.15188T>A	c.(15187-15189)CTG>CAG	p.L5063Q	GPR98_uc003kjt.2_Missense_Mutation_p.L2769Q|GPR98_uc003kjw.2_Missense_Mutation_p.L724Q	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5063	Calx-beta 33.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AATGGGGAACTGTTTTTTCAA	0.358													7	10					0	0	0	0	A	90106265	A	A	90106265	3	1	34	1	0	0	0	0	1	0	0	0	6760	1580	55	5	15482	5	GPR98	5	90106265	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	7262362	90106265	90808995	143	6435											
GPR98	84059	broad.mit.edu	37	chr5	90144565	90144565	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggacactaggggattcagtCactttgctgaagtgactgag	11	10	13	7	0	2	3	2	3	0	0	2	5	2	5	0	3	1	1	0	3	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:90144565C>G	uc003kju.2	+	79	17227	c.17131C>G	c.(17131-17133)CAC>GAC	p.H5711D	GPR98_uc003kjt.2_Missense_Mutation_p.H3417D|GPR98_uc003kjw.2_Missense_Mutation_p.H1372D	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5711	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGGATTCAGTCACTTTGCTGA	0.393													14	24					0	0	0	0	G	90144565	G	G	90144565	3	3	34	1	0	0	0	0	1	0	0	0	6760	826	29	2	17445	2	GPR98	5	90144565	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	38300	90144565	90770695	144	6436											
GPR98	84059	broad.mit.edu	37	chr5	90149125	90149125	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaaaccatccttgatagttgCccatatttgtcaatattggc	12	14	6	9	0	1	1	1	1	0	0	2	1	2	1	3	1	2	1	3	1	6	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:90149125C>A	uc003kju.2	+	80	17325	c.17229C>A	c.(17227-17229)TGC>TGA	p.C5743*	GPR98_uc003kjt.2_Nonsense_Mutation_p.C3449*|GPR98_uc003kjw.2_Nonsense_Mutation_p.C1404*	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5743	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGATAGTTGCCCATATTTGT	0.368													23	73					6.12954e-19	7.74091e-19	1	0	A	90149125	A	A	90149125	4	1	34	1	0	0	0	0	0	1	0	0	6760	747	26	4	17547	4	GPR98	5	90149125	Nonsense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	4560	90149125	90766135	145	6437											
SLC22A4	6583	broad.mit.edu	37	chr5	131647926	131647926	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttcgtaggcgtgctcctcGgctccttcgtgtccgggcag	2	12	13	14	5	1	0	0	0	1	0	7	0	4	0	3	3	1	4	3	3	1	3	rs141478353		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:131647926G>A	uc003kwq.2	+	2	631	c.466G>A	c.(466-468)GGC>AGC	p.G156S	SLC22A4_uc010jdq.1_RNA|uc003kwr.3_RNA	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	156	Helical; Name=2; (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CGTGCTCCTCGGCTCCTTCGT	0.587													64	219					0	0	0	0	A	131647926	A	A	131647926	3	1	34	1	0	0	0	0	1	0	0	0	14520	1116	39	1	472	1	SLC22A4	5	131647926	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	41498801	131647926	49267334	146	6438											
CATSPER3	347732	broad.mit.edu	37	chr5	134343829	134343829	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accctcttcagcttggccacGgtactgtgtttgggaacagt	7	12	11	11	1	2	0	1	0	1	0	2	1	2	1	2	3	3	3	2	3	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:134343829G>A	uc003lag.2	+	4	743	c.675G>A	c.(673-675)ACG>ACA	p.T225T		NM_178019	NP_821138	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	225					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCTTGGCCACGGTACTGTGTT	0.562													15	38					0	0	0	0	A	134343829	A	A	134343829	2	1	34	1	0	0	0	0	0	0	0	1	2701	1130	39	1		1	CATSPER3	5	134343829	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2695903	134343829	46571431	147	6439											
TRPC7	57113	broad.mit.edu	37	chr5	135692925	135692925	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgggatgttgccatactcagCcgagtccaggaagcgctcct	8	8	12	13	3	1	0	1	0	0	0	3	3	3	2	4	2	4	2	4	2	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:135692925C>A	uc003lbn.1	-	1	151	c.148G>T	c.(148-150)GCT>TCT	p.A50S	TRPC7_uc010jef.1_Missense_Mutation_p.A42S|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.A42S|TRPC7_uc010jei.1_Missense_Mutation_p.A42S|TRPC7_uc010jej.1_5'UTR	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	51	Cytoplasmic (Potential).|ANK 1.				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCATACTCAGCCGAGTCCAGG	0.607													49	178					1.38909e-20	1.78182e-20	1	0	A	135692925	A	A	135692925	3	1	34	1	0	0	0	0	1	0	0	0	16651	739	26	4	2481	4	TRPC7	5	135692925	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1349096	135692925	45222335	148	6440											
KDM3B	51780	broad.mit.edu	37	chr5	137726869	137726869	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctctgcacaagaggcacaGaaagacactgatctctccaa	15	6	8	12	0	2	4	0	1	2	3	4	4	3	4	1	1	2	3	1	1	3	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:137726869G>A	uc003lcy.1	+	8	1748	c.1548G>A	c.(1546-1548)CAG>CAA	p.Q516Q	KDM3B_uc010jew.1_Silent_p.Q172Q|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	516					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AAGAGGCACAGAAAGACACTG	0.438													15	42					0	0	0	0	A	137726869	A	A	137726869	2	1	34	1	0	0	0	0	0	0	0	1	8166	933	33	2		2	KDM3B	5	137726869	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2033944	137726869	43188391	149	6441											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139907848	139907848	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgctaaggaactggaagacTtgattcctaaaaatcatatc	15	11	7	8	0	1	2	1	1	0	1	3	4	2	4	1	2	2	1	1	2	7	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:139907848T>G	uc003lfs.1	+	29	5441	c.5317T>G	c.(5317-5319)TTG>GTG	p.L1773V	ANKHD1_uc003lfr.2_Missense_Mutation_p.L1773V|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.L512V|ANKHD1_uc003lfw.2_Missense_Mutation_p.L411V|ANKHD1_uc010jfl.2_Missense_Mutation_p.L208V|ANKHD1-EIF4EBP3_uc003lfx.1_5'UTR	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1773						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGGAAGACTTGATTCCTAA	0.393													24	75					0	0	0	0	G	139907848	G	G	139907848	3	3	34	1	0	0	0	0	1	0	0	0	629	1606	56	5	5431	5	ANKHD1-EIF4EBP3	5	139907848	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	2180979	139907848	41007412	150	6442											
PCDHB9	56127	broad.mit.edu	37	chr5	140568492	140568492	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgacttccgcgtgggcgcctCagaccgcggctccccggctt	3	7	13	18	7	1	1	1	0	0	1	3	2	3	1	5	3	0	2	5	3	0	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:140568492C>G	uc003liw.1	+	3	1601	c.1601C>G	c.(1600-1602)TCA>TGA	p.S534*		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	534	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGGGCGCCTCAGACCGCGGC	0.662													25	86					0	0	0	0	G	140568492	G	G	140568492	4	3	34	1	0	0	0	0	0	1	0	0	11603	827	29	2	1602	2	PCDHB9	5	140568492	Nonsense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	660644	140568492	40346768	151	6443											
PCDHGA1	56114	broad.mit.edu	37	chr5	140711648	140711648	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctacattcccgaaaacaaccCcagaggagcctccatcttct	12	8	5	16	1	2	1	0	0	2	1	4	3	4	2	5	1	4	0	5	1	4	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:140711648C>A	uc003lji.1	+	1	1397	c.1397C>A	c.(1396-1398)CCC>CAC	p.P466H	PCDHGA1_uc011dan.1_Missense_Mutation_p.P466H	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	466	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAACAACCCCAGAGGAGCC	0.483													25	96					6.55177e-30	8.94253e-30	1	0	A	140711648	A	A	140711648	3	1	34	1	0	0	0	0	1	0	0	0	11604	623	22	4	1399	4	PCDHGA1	5	140711648	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	143156	140711648	40203612	152	6444											
PCDHGA9	56107	broad.mit.edu	37	chr5	140784222	140784222	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aatcctgtaccctgccctccCcactgatggttctactggtg	6	12	8	15	0	1	1	0	1	1	0	3	1	3	1	5	2	3	2	5	2	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:140784222C>G	uc003lkh.1	+	1	1703	c.1703C>G	c.(1702-1704)CCC>CGC	p.P568R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.P568R	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	568	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGCCCTCCCCACTGATGGT	0.552													67	298					0	0	0	0	G	140784222	G	G	140784222	3	3	34	1	0	0	0	0	1	0	0	0	11615	623	22	4	1705	4	PCDHGA9	5	140784222	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	72574	140784222	40131038	153	6445											
FAT2	2196	broad.mit.edu	37	chr5	150945353	150945353	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctacaatcacctgagttcccGaggggctgttctcctgcacc	7	10	9	15	1	2	1	1	1	1	0	4	2	3	1	4	2	2	4	4	2	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:150945353G>A	uc003lue.3	-	1	3153	c.3140C>T	c.(3139-3141)TCG>TTG	p.S1047L	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.S1047L	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1047	Cadherin 9.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding	p.S1047*(1)		ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGAGTTCCCGAGGGGCTGTT	0.597													23	83					0	0	0	0	A	150945353	A	A	150945353	3	1	34	1	0	0	0	0	1	0	0	0	5722	1059	37	1	10001	1	FAT2	5	150945353	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	10161131	150945353	29969907	154	6446											
GRIA1	2890	broad.mit.edu	37	chr5	153085517	153085517	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcacagtgaagagtttgaGgaaggacgggaccagacaac	14	5	15	7	1	0	4	0	2	0	2	0	7	0	7	1	4	1	2	1	4	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:153085517G>C	uc003lva.3	+	11	2078	c.1713G>C	c.(1711-1713)GAG>GAC	p.E571D	GRIA1_uc003luy.3_Missense_Mutation_p.E571D|GRIA1_uc003luz.3_Missense_Mutation_p.E476D|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.E491D|GRIA1_uc011dcx.1_Missense_Mutation_p.E502D|GRIA1_uc011dcy.1_Missense_Mutation_p.E581D|GRIA1_uc011dcz.1_Missense_Mutation_p.E581D|GRIA1_uc010jia.1_Missense_Mutation_p.E551D	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	571	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AAGAGTTTGAGGAAGGACGGG	0.488													34	100					0	0	0	0	C	153085517	C	C	153085517	3	2	34	1	0	0	0	0	1	0	0	0	6806	991	35	4	1755	4	GRIA1	5	153085517	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2140164	153085517	27829743	155	6447											
FAM71B	153745	broad.mit.edu	37	chr5	156589904	156589904	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgctttctgattcttgtcccCcgctctcctgcggtgacttt	2	16	8	15	3	3	2	0	2	3	0	5	2	4	2	3	1	1	2	3	1	0	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:156589904C>T	uc003lwn.2	-	2	1472	c.1372G>A	c.(1372-1374)GGG>AGG	p.G458R		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	458	Bipartite nuclear localization signal (Potential).					nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTCTTGTCCCCCGCTCTCCTG	0.483													28	85					0	0	0	0	T	156589904	T	T	156589904	3	4	34	1	0	0	0	0	1	0	0	0	5640	623	22	4	449	4	FAM71B	5	156589904	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	3504387	156589904	24325356	156	6448											
CYFIP2	26999	broad.mit.edu	37	chr5	156810320	156810320	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgtctggaagccaagtatGccccgctccacctggtccct	8	8	9	16	2	1	0	0	0	1	0	3	1	3	1	6	2	3	2	6	2	4	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:156810320G>T	uc003lwq.2	+	30	3298	c.3160G>T	c.(3160-3162)GCC>TCC	p.A1054S	CYFIP2_uc011ddn.1_Missense_Mutation_p.A1028S|CYFIP2_uc011ddo.1_Missense_Mutation_p.A858S|CYFIP2_uc003lwr.2_Missense_Mutation_p.A1054S|CYFIP2_uc003lws.2_Missense_Mutation_p.A1054S|CYFIP2_uc003lwt.2_Missense_Mutation_p.A957S|CYFIP2_uc011ddp.1_Missense_Mutation_p.A788S|CYFIP2_uc003lwv.2_Missense_Mutation_p.A9S	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1079					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGCCAAGTATGCCCCGCTCCA	0.502													12	24					2.62699e-14	3.16271e-14	1	0	T	156810320	T	T	156810320	3	4	34	1	0	0	0	0	1	0	0	0	4155	1319	46	4	3266	4	CYFIP2	5	156810320	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	220416	156810320	24104940	157	6449											
ODZ2	57451	broad.mit.edu	37	chr5	167673800	167673800	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagagccaacgtcagtatatAtttgagtatgactcctctga	12	12	8	9	1	2	4	1	3	1	1	3	4	3	4	2	0	2	2	2	0	5	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:167673800A>G	uc010jjd.2	+	27	5829	c.5829A>G	c.(5827-5829)ATA>ATG	p.I1943M	ODZ2_uc003lzr.3_Missense_Mutation_p.I1713M|ODZ2_uc003lzt.3_Missense_Mutation_p.I1316M|ODZ2_uc010jje.2_Missense_Mutation_p.I1207M	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GTCAGTATATATTTGAGTATG	0.517													112	368					0	0	0	0	G	167673800	G	G	167673800	3	3	34	1	0	0	0	0	1	0	0	0	10889	439	16	5	5935	5	ODZ2	5	167673800	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	10863480	167673800	13241460	158	6450											
GABRP	2568	broad.mit.edu	37	chr5	170236736	170236736	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgctcactacagttccttaCagcagatggcagccaaagat	12	10	8	11	0	1	2	1	0	0	2	2	2	2	2	2	1	5	4	2	1	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:170236736C>A	uc003mau.2	+	9	1195	c.997C>A	c.(997-999)CAG>AAG	p.Q333K	GABRP_uc011dev.1_Intron	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	333	Cytoplasmic (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGTTCCTTACAGCAGATGGC	0.512											OREG0017032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	92					1.87028e-06	1.9966e-06	1	0	A	170236736	A	A	170236736	3	1	34	1	0	0	0	0	1	0	0	0	6208	479	17	4	1027	4	GABRP	5	170236736	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2562936	170236736	10678524	159	6451											
GRM6	2916	broad.mit.edu	37	chr5	178418425	178418425	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgattgtgccactgtcccacCtgatgtcatcctcattggca	7	13	8	13	0	2	2	2	2	0	0	4	2	4	2	4	1	1	1	4	1	0	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr5:178418425C>A	uc003mjr.2	-	3	1036	c.857G>T	c.(856-858)AGG>ATG	p.R286M	GRM6_uc010jla.1_5'Flank|GRM6_uc003mjs.1_5'Flank	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	286	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		ACTGTCCCACCTGATGTCATC	0.597													72	167					5.21738e-30	7.14111e-30	1	0	A	178418425	A	A	178418425	3	1	34	1	0	0	0	0	1	0	0	0	6840	695	24	4	1808	4	GRM6	5	178418425	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	8181689	178418425	2496835	160	6452											
NUP153	9972	broad.mit.edu	37	chr6	17629417	17629417	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcttttcttcctgtccaaGattagataccccaaattgaa	11	16	4	10	0	2	3	0	1	2	2	4	3	4	3	4	0	1	0	4	0	5	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:17629417G>C	uc003ncd.1	-	18	3213	c.3013C>G	c.(3013-3015)CTT>GTT	p.L1005V	NUP153_uc011dje.1_Missense_Mutation_p.L1036V|NUP153_uc010jpl.1_Missense_Mutation_p.L963V	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	1005					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TCCTGTCCAAGATTAGATACC	0.378													11	23					0	0	0	0	C	17629417	C	C	17629417	3	2	34	1	0	0	0	0	1	0	0	0	10809	942	33	2	1434	2	NUP153	6	17629417	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08		17629417	153485650	161	6453											
HIST1H3E	8353	broad.mit.edu	37	chr6	26225383	26225383	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttactttgcagatgaactAtggcgcgtactaagcagacg	12	11	10	8	3	0	3	0	1	0	2	0	3	0	3	0	1	5	3	0	1	5	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:26225383A>G	uc003nhb.2	+	2	361	c.1A>G	c.(1-3)ATG>GTG	p.M1V	HIST1H3E_uc003nhc.3_Missense_Mutation_p.M1V	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	1					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				CAGATGAACTATGGCGCGTAC	0.517													29	96					0	0	0	0	G	26225383	G	G	26225383	3	3	34	1	0	0	0	0	1	0	0	0	7198	463	16	5	3	5	HIST1H3E	6	26225383	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	8595966	26225383	144889684	162	6454											
HIST1H2AH	85235	broad.mit.edu	37	chr6	27114966	27114966	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggccaagacccgctcttCtcgggctgggcttcagttcc	6	9	11	15	2	3	1	1	0	2	1	5	1	4	1	3	3	0	4	3	3	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:27114966C>A	uc003niz.2	+	1	59	c.59C>A	c.(58-60)TCT>TAT	p.S20Y	HIST1H2BK_uc003nix.1_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080596	NP_542163	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	20					nucleosome assembly	nucleosome|nucleus	DNA binding				0						ACCCGCTCTTCTCGGGCTGGG	0.617													18	62					6.33239e-15	7.69943e-15	1	0	A	27114966	A	A	27114966	3	1	34	1	0	0	0	0	1	0	0	0	7173	913	32	2	61	2	HIST1H2AH	6	27114966	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	889583	27114966	144000101	163	6455											
ZNF193	7746	broad.mit.edu	37	chr6	28200832	28200832	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtcggcgttcatttctcaTtgaacatcagagaagccaca	12	10	8	11	2	3	2	3	1	1	1	5	3	3	2	1	1	2	1	1	1	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:28200832T>A	uc003nkq.1	+	4	1176	c.1061T>A	c.(1060-1062)ATT>AAT	p.I354N	ZNF193_uc003nkr.1_Missense_Mutation_p.I354N|ZNF193_uc010jqz.1_Missense_Mutation_p.I405N	NM_006299	NP_006290	O15535	ZN193_HUMAN	zinc finger protein 193	354	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TCATTTCTCATTGAACATCAG	0.493													8	20					0	0	0	0	A	28200832	A	A	28200832	3	1	34	1	0	0	0	0	1	0	0	0	17824	1493	52	5	1071	5	ZNF193	6	28200832	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	1085866	28200832	142914235	164	6456											
RNF39	80352	broad.mit.edu	37	chr6	30043524	30043525	+	Frame_Shift_Ins	INS	-	CC	CC																															tctcctgggattgcctctctINScttcaaccagagtctcagtc																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:30043524_30043525insCC	uc003npe.2	-	1	104_105	c.42_43insGG	c.(40-45)AAGAGAfs	p.K14fs	RNF39_uc003npd.2_Frame_Shift_Ins_p.K14fs	NM_025236	NP_079512	Q9H2S5	RNF39_HUMAN	ring finger protein 39 isoform 1	14_15						cytoplasm	zinc ion binding				0						ATTGCCTCTCTCTTCAACCAGA	0.579													---	---	---								CC	30043525	CC	CC	30043524	7	5	34	1	0	1	1	0	0	0	0	0	13556	1559	54	0	1235	0	RNF39	6	30043524	Frame_Shift_Ins	INS	-	TCGA-BB-7871-01A-11D-2229-08	1842692	30043524	141071543	165	6457											
DHX16	8449	broad.mit.edu	37	chr6	30638996	30638996	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttcttctccagcagggccCgggcctctcgctctgctgcc	2	10	12	17	2	4	0	0	0	4	0	6	0	4	0	4	3	3	4	4	3	0	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:30638996C>A	uc003nqz.2	-	2	475	c.263G>T	c.(262-264)CGG>CTG	p.R88L	DHX16_uc011dmo.1_Missense_Mutation_p.R28L	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	88					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						CAGCAGGGCCCGGGCCTCTCG	0.547													78	305					3.89792e-41	5.48846e-41	1	0	A	30638996	A	A	30638996	3	1	34	1	0	0	0	0	1	0	0	0	4524	652	23	3	2938	3	DHX16	6	30638996	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	595472	30638996	140476071	166	6458											
BAT4	7918	broad.mit.edu	37	chr6	31630061	31630062	+	Frame_Shift_Ins	INS	-	T	T																															gtcagaactcgaggttcatgINStaagtccttagatcccgctc																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:31630061_31630062insT	uc003nvn.2	-	3	1697_1698	c.1052_1053insA	c.(1051-1053)TACfs	p.Y351fs	C6orf47_uc003nvm.1_5'Flank|BAT4_uc003nvo.3_Frame_Shift_Ins_p.Y351fs|BAT4_uc003nvp.3_Frame_Shift_Ins_p.Y351fs|BAT4_uc003nvq.2_Frame_Shift_Ins_p.Y351fs	NM_033177	NP_149417	O95872	GPAN1_HUMAN	HLA-B associated transcript 4	351						intracellular	nucleic acid binding				0						CGAGGTTCATGTAAGTCCTTAG	0.579													---	---	---								T	31630062	T	T	31630061	7	5	34	1	0	1	1	0	0	0	0	0	1325	1372	48	0	21	0	BAT4	6	31630061	Frame_Shift_Ins	INS	-	TCGA-BB-7871-01A-11D-2229-08	991065	31630061	139485006	167	6459											
C6orf25	80739	broad.mit.edu	37	chr6	31691750	31691750	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacctattgcaaggccccCgggcctacccatggtaggtg	8	7	13	13	1	0	0	0	0	0	0	0	1	0	1	5	5	2	2	5	5	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:31691750C>T	uc011doc.1	+	2	396	c.396C>T	c.(394-396)CCC>CCT	p.P132P	LY6G6C_uc003nwh.2_5'Flank|LY6G6C_uc010jtd.2_5'Flank|C6orf25_uc003nwk.2_Silent_p.P132P|C6orf25_uc011dod.1_Silent_p.P132P|C6orf25_uc011doe.1_Silent_p.P132P|C6orf25_uc003nwo.2_Silent_p.P132P|C6orf25_uc003nwn.2_Silent_p.P132P	NM_138272	NP_612116	O95866	G6B_HUMAN	G6B protein isoform G6b-B precursor	132	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity				0						GCAAGGCCCCCGGGCCTACCC	0.637													30	97					0	0	0	0	T	31691750	T	T	31691750	2	4	34	1	0	0	0	0	0	0	0	1	2370	639	23	1		1	C6orf25	6	31691750	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	61689	31691750	139423317	168	6460											
B3GALT4	8705	broad.mit.edu	37	chr6	33246192	33246192	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattcctgctgacgtcccaCaggctggacccctggaagat	10	8	10	13	1	0	2	0	1	0	1	2	4	2	4	4	3	1	2	4	3	2	1	rs141217533	byFrequency	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:33246192C>G	uc003odr.2	+	1	1276	c.996C>G	c.(994-996)CAC>CAG	p.H332Q		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	332	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						TGACGTCCCACAGGCTGGACC	0.627													38	140					0	0	0	0	G	33246192	G	G	33246192	3	3	34	1	0	0	0	0	1	0	0	0	1251	477	17	4	998	4	B3GALT4	6	33246192	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1554442	33246192	137868875	169	6461											
LRFN2	57497	broad.mit.edu	37	chr6	40399496	40399496	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagcagttgtactgcagctGgtacatcttcacccggggtg	8	10	13	10	1	2	1	1	0	1	1	2	1	2	1	1	3	5	6	1	3	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:40399496G>A	uc003oph.1	-	2	1822	c.1357C>T	c.(1357-1359)CAG>TAG	p.Q453*		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	453	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TACTGCAGCTGGTACATCTTC	0.597													20	70					0	0	0	0	A	40399496	A	A	40399496	4	1	34	1	0	0	0	0	0	1	0	0	8988	1357	47	4	1020	4	LRFN2	6	40399496	Nonsense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	7153304	40399496	130715571	170	6462											
RPL7L1	285855	broad.mit.edu	37	chr6	42851353	42851353	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tttgttgtacgcatcgaaagGtaaggaactggtgtctttct	9	15	11	6	2	2	0	0	0	2	0	3	2	2	1	0	3	2	4	0	3	4	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:42851353G>T	uc003osq.1	+	3	289	c.284_splice	c.e3+1	p.R95_splice	RPL7L1_uc011dux.1_Splice_Site_p.R95_splice|RPL7L1_uc010jxw.1_Splice_Site|RPL7L1_uc003osr.1_Splice_Site|RPL7L1_uc011duy.1_Splice_Site_p.R95_splice|RPL7L1_uc003oss.1_Splice_Site|RPL7L1_uc003ost.2_Splice_Site_p.R95_splice|RPL7L1_uc003osu.2_Splice_Site	NM_198486	NP_940888	Q6DKI1	RL7L_HUMAN	ribosomal protein L7-like 1						translation	large ribosomal subunit	protein binding|structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00237)|all cancers(41;0.00288)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.088)			GCATCGAAAGGTAAGGAACTG	0.468													15	31					8.60227e-14	1.02808e-13	1	0	T	42851353	T	T	42851353	5	4	34	1	0	0	0	0	0	0	1	0	13666	1275	44	4	295	4	RPL7L1	6	42851353	Splice_Site	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2451857	42851353	128263714	171	6463											
LRRC1	55227	broad.mit.edu	37	chr6	53787436	53787436	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccactgtttgtttttagagaAcacttctaaggcgagccact	10	13	8	10	1	1	1	0	0	1	1	1	3	1	1	2	1	2	2	2	1	3	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:53787436A>C	uc003pcd.1	+	14	1697	c.1420A>C	c.(1420-1422)ACA>CCA	p.T474P		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	474						cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		TTTTTAGAGAACACTTCTAAG	0.403													22	75					0	0	0	0	C	53787436	C	C	53787436	3	2	34	1	0	0	0	0	1	0	0	0	9016	43	2	5	1474	5	LRRC1	6	53787436	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	10936083	53787436	117327631	172	6464											
C6orf221	154288	broad.mit.edu	37	chr6	74073398	74073398	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtccgggaggccgggaccCagcgttcggtggaagtccag	7	5	18	11	4	0	0	0	0	0	0	3	3	2	3	4	6	1	1	4	6	1	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:74073398C>T	uc003pgt.3	+	3	522	c.469C>T	c.(469-471)CAG>TAG	p.Q157*		NM_001017361	NP_001017361	Q587J8	ECAT1_HUMAN	hypothetical protein LOC154288	157										skin(2)	2						GGCCGGGACCCAGCGTTCGGT	0.672													12	48					0	0	0	0	T	74073398	T	T	74073398	4	4	34	1	0	0	0	0	0	1	0	0	2365	595	21	4	479	4	C6orf221	6	74073398	Nonsense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	20285962	74073398	97041669	173	6465											
MYO6	4646	broad.mit.edu	37	chr6	76550980	76550980	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttatctcctagagaaatctaGgatctgtgttcaaggcaaag	13	12	9	7	0	4	1	1	0	3	1	5	3	4	2	1	2	0	2	1	2	6	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:76550980G>A	uc003pih.1	+	9	980	c.701G>A	c.(700-702)AGG>AAG	p.R234K	MYO6_uc003pig.1_Missense_Mutation_p.R234K|MYO6_uc003pii.1_Missense_Mutation_p.R234K	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	234	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GAGAAATCTAGGATCTGTGTT	0.313													10	45					0	0	0	0	A	76550980	A	A	76550980	3	1	34	1	0	0	0	0	1	0	0	0	10134	1000	35	4	731	4	MYO6	6	76550980	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2477582	76550980	94564087	174	6466											
KIAA1009	22832	broad.mit.edu	37	chr6	84872925	84872925	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttcattttttcgaagtctActtcaagagcttgtttgtct	7	20	6	8	1	5	1	2	0	3	1	6	2	5	1	0	0	2	2	0	0	3	8			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:84872925A>G	uc010kbp.2	-	19	2547	c.2450T>C	c.(2449-2451)GTA>GCA	p.V817A	KIAA1009_uc003pkj.3_Missense_Mutation_p.V741A|KIAA1009_uc003pki.3_Missense_Mutation_p.V203A	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	817	Potential.				cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		TTCGAAGTCTACTTCAAGAGC	0.328													23	76					0	0	0	0	G	84872925	G	G	84872925	3	3	34	1	0	0	0	0	1	0	0	0	8242	391	14	5	1797	5	KIAA1009	6	84872925	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	8321945	84872925	86242142	175	6467											
MDN1	23195	broad.mit.edu	37	chr6	90411328	90411328	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcaacttctttataccagcGaagccaccagtctggctccc	9	10	7	15	1	2	0	0	0	2	0	3	1	3	0	4	1	5	2	4	1	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:90411328G>A	uc003pnn.1	-	55	8492	c.8376C>T	c.(8374-8376)TTC>TTT	p.F2792F		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2792					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTATACCAGCGAAGCCACCAG	0.413													16	44					0	0	0	0	A	90411328	A	A	90411328	2	1	34	1	0	0	0	0	0	0	0	1	9468	1049	37	1		1	MDN1	6	90411328	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	5538403	90411328	80703739	176	6468											
LAMA2	3908	broad.mit.edu	37	chr6	129636919	129636919	+	Frame_Shift_Del	DEL	G	-	-																															tttgtcagttgatggcctatGggggcaaactcaagtatgca																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:129636919delG	uc003qbn.2	+	26	3853	c.3748delG	c.(3748-3750)GGGfs	p.G1250fs	LAMA2_uc003qbo.2_Frame_Shift_Del_p.G1250fs	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1250	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GATGGCCTATGGGGGCAAACT	0.383													---	---	---								-	129636919	-	-	129636919	7	5	34	1	0	1	0	1	0	0	0	0	8646	1348	47	0	3850	0	LAMA2	6	129636919	Frame_Shift_Del	DEL	G	TCGA-BB-7871-01A-11D-2229-08	39225591	129636919	41478148	177	6469											
SYNE1	23345	broad.mit.edu	37	chr6	152647535	152647535	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttctttgccggttggcttGatgagtgggtccagggtggc	3	14	16	8	1	2	2	0	2	2	0	3	2	3	2	2	5	1	2	2	5	0	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:152647535G>A	uc010kiw.2	-	79	15791	c.15189C>T	c.(15187-15189)ATC>ATT	p.I5063I	SYNE1_uc003qot.3_Silent_p.I4992I|SYNE1_uc003qou.3_Silent_p.I5063I|SYNE1_uc010kiz.2_Silent_p.I818I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5063	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CGGTTGGCTTGATGAGTGGGT	0.517										HNSCC(10;0.0054)			21	47					0	0	0	0	A	152647535	A	A	152647535	2	1	34	1	0	0	0	0	0	0	0	1	15511	1280	45	2		2	SYNE1	6	152647535	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	23010616	152647535	18467532	178	6470											
SYNE1	23345	broad.mit.edu	37	chr6	152711563	152711564	+	Missense_Mutation	DNP	CT	AC	AC																															catattcaacttaacttcccCttcacctttcatcaggagaa																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:152711563_152711564CT>AC	uc010kiw.2	-	53	8630_8631	c.8028_8029AG>GT	c.(8026-8031)GAAGGG>GAGTGG	p.G2677W	SYNE1_uc003qot.3_Missense_Mutation_p.G2684W|SYNE1_uc003qou.3_Missense_Mutation_p.G2677W|SYNE1_uc010kjb.1_Missense_Mutation_p.G2660W	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2677	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTAACTTCCCCTTCACCTTTCA	0.411										HNSCC(10;0.0054)			13	45					0	0	0	0	AC	152711564	AC	AC	152711563	3	1	34	1	0	0	0	0	1	0	0	0	15511	681	24	4	18813	4	SYNE1	6	152711563	Missense_Mutation	DNP	CT	TCGA-BB-7871-01A-11D-2229-08	64028	152711563	18403504	179	6471											
SYNE1	23345	broad.mit.edu	37	chr6	152749342	152749342	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaaaagtgctgctcacctCtgccagtgggccagcagatt	10	8	12	11	0	2	1	1	0	1	1	2	2	2	2	3	2	4	3	3	2	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:152749342C>G	uc010kiw.2	-	37	5576	c.4974G>C	c.(4972-4974)CAG>CAC	p.Q1658H	SYNE1_uc003qot.3_Missense_Mutation_p.Q1665H|SYNE1_uc003qou.3_Missense_Mutation_p.Q1658H|SYNE1_uc010kjb.1_Missense_Mutation_p.Q1641H|SYNE1_uc003qow.2_Missense_Mutation_p.Q953H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1658	Spectrin 2.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGCTCACCTCTGCCAGTGGG	0.507										HNSCC(10;0.0054)			74	372					0	0	0	0	G	152749342	G	G	152749342	3	3	34	1	0	0	0	0	1	0	0	0	15511	912	32	2	21932	2	SYNE1	6	152749342	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	37779	152749342	18365725	180	6472											
RGS17	26575	broad.mit.edu	37	chr6	153345580	153345580	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgctggggccttcatcatCttgtcaaaattttgagacca	9	13	8	11	0	4	1	3	1	1	1	4	2	4	1	3	2	1	1	3	2	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:153345580C>G	uc003qpm.2	-	4	417	c.261G>C	c.(259-261)AAG>AAC	p.K87N		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	87	RGS.				negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		CCTTCATCATCTTGTCAAAAT	0.473									Lung_Cancer_Familial_Clustering_of				20	45					0	0	0	0	G	153345580	G	G	153345580	3	3	34	1	0	0	0	0	1	0	0	0	13364	912	32	2	379	2	RGS17	6	153345580	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	596238	153345580	17769487	181	6473											
SLC22A2	6582	broad.mit.edu	37	chr6	160645781	160645781	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atggtctcaggcaaagctttCcctttagtttctggaagcaa	10	13	9	9	0	2	0	1	0	2	0	4	1	3	1	1	3	2	4	1	3	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:160645781C>A	uc003qtf.2	-	10	1727	c.1557G>T	c.(1555-1557)GGG>GGT	p.G519G	SLC22A2_uc003qte.1_Silent_p.G519G	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	519	Cytoplasmic (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		GCAAAGCTTTCCCTTTAGTTT	0.378													34	107					3.09479e-21	4.0224e-21	1	0	A	160645781	A	A	160645781	2	1	34	1	0	0	0	0	0	0	0	1	14515	842	30	2		2	SLC22A2	6	160645781	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	7300201	160645781	10469286	182	6474											
FRMD1	79981	broad.mit.edu	37	chr6	168479649	168479649	+	Frame_Shift_Del	DEL	C	-	-																															atcgcgtccattcccagggtCggctcctgctgactgcatgc																								rs146200905		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr6:168479649delC	uc003qwo.3	-	1	191	c.126delG	c.(124-126)CCGfs	p.P42fs		NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	42						cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		TTCCCAGGGTCGGCTCCTGCT	0.667													---	---	---								-	168479649	-	-	168479649	7	5	34	1	0	1	0	1	0	0	0	0	6083	871	31	0	1580	0	FRMD1	6	168479649	Frame_Shift_Del	DEL	C	TCGA-BB-7871-01A-11D-2229-08	7833868	168479649	2635418	183	6475											
C7orf30	115416	broad.mit.edu	37	chr7	23340489	23340489	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaagtttgacatcgatatGatggtttcacttctgaggca	10	13	9	9	1	2	3	1	3	1	0	3	4	2	3	1	2	0	3	1	2	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:23340489G>A	uc003swd.1	+	2	320	c.288G>A	c.(286-288)ATG>ATA	p.M96I		NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	96						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			ACATCGATATGATGGTTTCAC	0.408													46	126					0	0	0	0	A	23340489	A	A	23340489	3	1	34	1	0	0	0	0	1	0	0	0	2397	1290	45	2	294	2	C7orf30	7	23340489	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08		23340489	135798174	184	6476											
HOXA6	3203	broad.mit.edu	37	chr7	27186927	27186927	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtcttgggatatgtcttacCcgcgcaggagttcatccgct	6	13	11	11	3	3	0	1	0	2	0	4	2	4	2	2	2	1	3	2	2	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:27186927C>A	uc003syo.1	-	1	442	c.442G>T	c.(442-444)GGT>TGT	p.G148C	uc003syp.1_Missense_Mutation_p.P4T	NM_024014	NP_076919	P31267	HXA6_HUMAN	homeobox A6	148						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						TATGTCTTACCCGCGCAGGAG	0.453													21	89					1.36565e-18	1.71142e-18	1	0	A	27186927	A	A	27186927	3	1	34	1	0	0	0	0	1	0	0	0	7335	637	22	4	267	4	HOXA6	7	27186927	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	3846438	27186927	131951736	185	6477											
EPDR1	54749	broad.mit.edu	37	chr7	37989907	37989907	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacgcggttttttgacatccAgctgggtattaaagacccct	9	13	9	10	2	0	2	0	1	0	1	1	2	1	2	3	2	2	3	3	2	4	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:37989907A>T	uc003tfp.2	+	3	963	c.944A>T	c.(943-945)CAG>CTG	p.Q315L	EPDR1_uc003tfq.2_3'UTR|EPDR1_uc010kxh.2_Missense_Mutation_p.Q134L	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	195					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						TTTGACATCCAGCTGGGTATT	0.493													9	31					0	0	0	0	T	37989907	T	T	37989907	3	4	34	1	0	0	0	0	1	0	0	0	5187	188	7	5	954	5	EPDR1	7	37989907	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	10802980	37989907	121148756	186	6478											
AEBP1	165	broad.mit.edu	37	chr7	44151818	44151819	+	Missense_Mutation	DNP	CA	TC	TC																															tttgaagatttcccggatctCaactctgtgctctggggagc																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:44151818_44151819CA>TC	uc003tkb.2	+	17	2420_2421	c.2115_2116CA>TC	c.(2113-2118)CTCAAC>CTTCAC	p.N706H	AEBP1_uc003tkc.3_Missense_Mutation_p.N281H|AEBP1_uc003tkd.2_5'UTR	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	706	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TCCCGGATCTCAACTCTGTGCT	0.579													33	75					0	0	0	0	TC	44151819	TC	TC	44151818	3	4	34	1	0	0	0	0	1	0	0	0	349	813	29	2	2181	2	AEBP1	7	44151818	Missense_Mutation	DNP	CA	TCGA-BB-7871-01A-11D-2229-08	6161911	44151818	114986845	187	6479											
AUTS2	26053	broad.mit.edu	37	chr7	69064857	69064857	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgtcccggcccagaccccCgcggaggaagcggagagagt	8	2	15	16	5	0	2	0	0	0	2	1	6	1	5	5	4	1	0	5	4	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:69064857C>A	uc003tvw.3	+	1	961	c.218C>A	c.(217-219)CCG>CAG	p.P73Q	AUTS2_uc003tvv.3_Missense_Mutation_p.P73Q|AUTS2_uc003tvx.3_Missense_Mutation_p.P73Q	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	73										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CCCAGACCCCCGCGGAGGAAG	0.562													15	36					0.000308642	0.00031906	1	0	A	69064857	A	A	69064857	3	1	34	1	0	0	0	0	1	0	0	0	1227	652	23	3	220	3	AUTS2	7	69064857	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	24913039	69064857	90073806	188	6480											
CALN1	83698	broad.mit.edu	37	chr7	71743729	71743729	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgtcactgccagcagagagCgatcggttgaggtaattccc	9	9	12	11	2	1	2	1	1	0	1	3	4	2	2	2	2	3	3	2	2	1	3	rs146054367	byFrequency	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:71743729C>T	uc003twa.3	-	2	587	c.60G>A	c.(58-60)TCG>TCA	p.S20S	CALN1_uc003twb.3_Silent_p.S62S|CALN1_uc003twc.3_Silent_p.S20S	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	20	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CAGCAGAGAGCGATCGGTTGA	0.572													17	34					0	0	0	0	T	71743729	T	T	71743729	2	4	34	1	0	0	0	0	0	0	0	1	2603	755	27	1		1	CALN1	7	71743729	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2678872	71743729	87394934	189	6481											
SEMA3E	9723	broad.mit.edu	37	chr7	83014750	83014750	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcttatccaaagcatcccCtacaacaggaacattaatgc	15	9	5	12	0	1	0	0	0	1	0	3	1	3	1	3	1	5	1	3	1	6	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:83014750C>T	uc003uhy.1	-	16	2202	c.1736_splice	c.e16-1	p.G579_splice		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor						axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				AAAGCATCCCCTACAACAGGA	0.353													32	109					0	0	0	0	T	83014750	T	T	83014750	5	4	34	1	0	0	0	0	0	0	1	0	14093	695	24	4	600	4	SEMA3E	7	83014750	Splice_Site	SNP	C	TCGA-BB-7871-01A-11D-2229-08	11271021	83014750	76123913	190	6482											
GAL3ST4	79690	broad.mit.edu	37	chr7	99758003	99758003	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacagtgctgaggccctgctTatgtccagcctgggcattgt	6	11	13	11	0	0	1	0	1	0	0	1	2	1	1	3	2	3	3	3	2	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:99758003T>C	uc003utt.2	-	3	2026	c.1009A>G	c.(1009-1011)AAG>GAG	p.K337E	C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.K337E|GAL3ST4_uc010lgq.2_Missense_Mutation_p.K275E	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	337	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGGCCCTGCTTATGTCCAGCC	0.597													32	118					0	0	0	0	C	99758003	C	C	99758003	3	2	34	1	0	0	0	0	1	0	0	0	6235	1763	61	5	455	5	GAL3ST4	7	99758003	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	16743253	99758003	59380660	191	6483											
MUC17	140453	broad.mit.edu	37	chr7	100675429	100675429	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaactcctgttgaaatcagCacacctgtgaccatttctgc	11	11	6	13	0	2	2	1	2	1	0	3	2	3	2	3	0	3	2	3	0	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:100675429C>A	uc003uxp.1	+	3	785	c.732C>A	c.(730-732)AGC>AGA	p.S244R	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	244	Extracellular (Potential).|1.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TTGAAATCAGCACACCTGTGA	0.493													49	185					1.05386e-31	1.45873e-31	1	0	A	100675429	A	A	100675429	3	1	34	1	0	0	0	0	1	0	0	0	10027	709	25	4	742	4	MUC17	7	100675429	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	917426	100675429	58463234	192	6484											
FBXL13	222235	broad.mit.edu	37	chr7	102572330	102572330	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggttgcttatactcactgTgaatgttgggcagtcagaga	10	13	12	6	0	2	2	2	1	0	1	2	3	2	2	0	2	2	4	0	2	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:102572330T>A	uc003vaq.2	-	9	1202	c.775A>T	c.(775-777)ACA>TCA	p.T259S	FBXL13_uc010liq.1_Missense_Mutation_p.T74S|FBXL13_uc010lir.1_Missense_Mutation_p.T259S|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.T259S|LRRC17_uc003vat.2_Intron|LRRC17_uc003vau.2_Intron	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	259	LRR 2.										0						ATACTCACTGTGAATGTTGGG	0.373													19	54					0	0	0	0	A	102572330	A	A	102572330	3	1	34	1	0	0	0	0	1	0	0	0	5741	1696	59	5	1480	5	FBXL13	7	102572330	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	1896901	102572330	56566333	193	6485											
DOCK4	9732	broad.mit.edu	37	chr7	111395598	111395598	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcttttccacttcaaaccaGcgagagatgccaggcaaact	12	8	8	13	2	1	1	1	0	0	1	2	3	2	1	3	1	4	2	3	1	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:111395598G>T	uc003vfx.2	-	41	4631	c.4362C>A	c.(4360-4362)CGC>CGA	p.R1454R	DOCK4_uc011kml.1_Silent_p.R335R|DOCK4_uc011kmm.1_Silent_p.R361R|DOCK4_uc003vfw.2_Silent_p.R904R|DOCK4_uc003vfy.2_Silent_p.R1499R	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1454	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CTTCAAACCAGCGAGAGATGC	0.443													14	51					2.94398e-08	3.22718e-08	1	0	T	111395598	T	T	111395598	2	4	34	1	0	0	0	0	0	0	0	1	4711	958	34	4		4	DOCK4	7	111395598	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	8823268	111395598	47743065	194	6486											
CFTR	1080	broad.mit.edu	37	chr7	117171062	117171062	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatctaggcataggcttatGccttctctttattgtgagga	8	17	9	7	0	2	1	0	1	2	0	3	2	2	2	1	3	1	2	1	3	5	8			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:117171062G>C	uc003vjd.2	+	4	515	c.383G>C	c.(382-384)TGC>TCC	p.C128S	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	128	Helical; Name=2; (Potential).|ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ATAGGCTTATGCCTTCTCTTT	0.428									Cystic_Fibrosis				15	36					0	0	0	0	C	117171062	C	C	117171062	3	2	34	1	0	0	0	0	1	0	0	0	3309	1319	46	4	397	4	CFTR	7	117171062	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	5775464	117171062	41967601	195	6487											
KCND2	3751	broad.mit.edu	37	chr7	119914918	119914918	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agagggactttttctaccacCcagaaactcagcagtatttc	12	11	7	11	0	2	2	1	0	1	2	3	3	2	3	2	1	3	2	2	1	3	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:119914918C>A	uc003vjj.1	+	1	1197	c.232C>A	c.(232-234)CCA>ACA	p.P78T		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	78	Cytoplasmic (Potential).|Interaction with KCNIP1 (By similarity).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					TTTCTACCACCCAGAAACTCA	0.542													59	200					8.81991e-31	1.21398e-30	1	0	A	119914918	A	A	119914918	3	1	34	1	0	0	0	0	1	0	0	0	8058	623	22	4	234	4	KCND2	7	119914918	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2743856	119914918	39223745	196	6488											
TNPO3	23534	broad.mit.edu	37	chr7	128640492	128640492	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaacactacctcatattgAggatggcctgcacagataag	15	9	8	9	0	1	2	1	1	0	1	1	3	1	3	2	2	3	1	2	2	5	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:128640492A>T	uc003vol.1	-	7	1376	c.1002T>A	c.(1000-1002)CCT>CCA	p.P334P	TNPO3_uc003vom.1_Silent_p.P268P|TNPO3_uc010lly.1_Silent_p.P334P|TNPO3_uc010llz.1_Silent_p.P334P	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	334					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						CCTCATATTGAGGATGGCCTG	0.398													18	65					0	0	0	0	T	128640492	T	T	128640492	2	4	34	1	0	0	0	0	0	0	0	1	16403	291	11	5		5	TNPO3	7	128640492	Silent	SNP	A	TCGA-BB-7871-01A-11D-2229-08	8725574	128640492	30498171	197	6489											
CPA5	93979	broad.mit.edu	37	chr7	129986364	129986364	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcgggacgcgccctgggcCatcccccgtggacaggcgga	6	3	17	15	5	0	0	0	0	0	0	1	3	1	3	4	6	0	0	4	6	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:129986364C>A	uc010lmd.1	+	4	658	c.38C>A	c.(37-39)CCA>CAA	p.P13Q	CPA5_uc003vps.2_Missense_Mutation_p.P13Q|CPA5_uc003vpt.2_Missense_Mutation_p.P13Q|CPA5_uc010lme.1_Missense_Mutation_p.P13Q|CPA5_uc003vpu.1_Missense_Mutation_p.P13Q	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1	13					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)					CGCCCTGGGCCATCCCCCGTG	0.627													29	148					2.20474e-14	2.67406e-14	1	0	A	129986364	A	A	129986364	3	1	34	1	0	0	0	0	1	0	0	0	3808	594	21	4	40	4	CPA5	7	129986364	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1345872	129986364	29152299	198	6490											
KIAA1549	57670	broad.mit.edu	37	chr7	138603863	138603863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtattggagaaaccatcCgtggagtggtccagtgagta	11	10	13	7	1	0	2	0	1	0	1	2	4	2	3	3	3	1	2	3	3	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:138603863C>T	uc011kql.1	-	2	558	c.509G>A	c.(508-510)CGG>CAG	p.R170Q	KIAA1549_uc003vuk.3_Missense_Mutation_p.R120Q|KIAA1549_uc011kqj.1_Missense_Mutation_p.R170Q	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	170						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						AGAAACCATCCGTGGAGTGGT	0.478			O	BRAF	pilocytic astrocytoma								42	127					0	0	0	0	T	138603863	T	T	138603863	3	4	34	1	0	0	0	0	1	0	0	0	8283	652	23	1	5419	1	KIAA1549	7	138603863	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	8617499	138603863	20534800	199	6491											
TAS2R3	50831	broad.mit.edu	37	chr7	141464364	141464364	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgatggtatggatgctgttgGgtgcactgctcttatcctgt	5	16	13	7	0	1	1	0	1	1	0	2	2	2	2	1	3	3	5	1	3	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:141464364G>T	uc003vwp.1	+	1	468	c.406G>T	c.(406-408)GGT>TGT	p.G136C		NM_016943	NP_058639	Q9NYW6	TA2R3_HUMAN	taste receptor T2R3	136	Helical; Name=4; (Potential).				sensory perception of taste		taste receptor activity			central_nervous_system(1)	1	Melanoma(164;0.0171)					GATGCTGTTGGGTGCACTGCT	0.483													36	101					1.07121e-22	1.4148e-22	1	0	T	141464364	T	T	141464364	3	4	34	1	0	0	0	0	1	0	0	0	15638	1232	43	4	408	4	TAS2R3	7	141464364	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2860501	141464364	17674299	200	6492											
CNTNAP2	26047	broad.mit.edu	37	chr7	146997362	146997362	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccccttcaagttaaaactgGcgagaagtacttttttggag	11	13	9	8	1	1	1	1	0	0	1	2	3	2	2	2	2	2	2	2	2	5	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:146997362G>T	uc003weu.1	+	9	1994	c.1478G>T	c.(1477-1479)GGC>GTC	p.G493V		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	493	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTTAAAACTGGCGAGAAGTAC	0.373										HNSCC(39;0.1)			21	78					5.35356e-11	6.11479e-11	1	0	T	146997362	T	T	146997362	3	4	34	1	0	0	0	0	1	0	0	0	3662	1203	42	4	1512	4	CNTNAP2	7	146997362	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	5532998	146997362	12141301	201	6493											
CNTNAP2	26047	broad.mit.edu	37	chr7	147914428	147914428	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggctacgatataactttcAggcaccagcaacaaatgcca	14	8	8	11	1	1	0	1	0	0	0	1	1	1	0	2	2	5	3	2	2	5	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:147914428A>T	uc003weu.1	+	19	3575	c.3059A>T	c.(3058-3060)CAG>CTG	p.Q1020L		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1020	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TATAACTTTCAGGCACCAGCA	0.498										HNSCC(39;0.1)			44	94					0	0	0	0	T	147914428	T	T	147914428	3	4	34	1	0	0	0	0	1	0	0	0	3662	188	7	5	3133	5	CNTNAP2	7	147914428	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	917066	147914428	11224235	202	6494											
ABCB8	11194	broad.mit.edu	37	chr7	150738275	150738275	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgggacctgcgcacccttGacccctcctggctccggggc	3	6	14	18	3	0	1	0	1	0	0	2	2	2	2	6	5	1	2	6	5	0	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:150738275G>A	uc003wil.3	+	14	1717	c.1624G>A	c.(1624-1626)GAC>AAC	p.D542N	ABCB8_uc010lpw.1_Silent_p.*417*|ABCB8_uc010lpx.2_Missense_Mutation_p.D525N|ABCB8_uc011kvd.1_Missense_Mutation_p.D437N|ABCB8_uc003wim.3_Missense_Mutation_p.D320N|ABCB8_uc003wik.3_Missense_Mutation_p.D525N	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	542	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCGCACCCTTGACCCCTCCTG	0.687													21	61					0	0	0	0	A	150738275	A	A	150738275	3	1	34	1	0	0	0	0	1	0	0	0	47	1290	45	2	1623	2	ABCB8	7	150738275	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2823847	150738275	8400388	203	6495											
SLC4A2	6522	broad.mit.edu	37	chr7	150767628	150767628	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactgctggagaagattcctGagaatgccgaggccacggtg	11	7	14	9	2	0	3	0	1	0	3	1	6	1	3	3	3	3	1	3	3	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:150767628G>C	uc003wit.3	+	11	1790	c.1534G>C	c.(1534-1536)GAG>CAG	p.E512Q	SLC4A2_uc011kve.1_Missense_Mutation_p.E503Q|SLC4A2_uc003wiu.3_Missense_Mutation_p.E498Q|SLC4A2_uc003wiv.3_5'Flank	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	512	Cytoplasmic (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAAGATTCCTGAGAATGCCGA	0.617													6	19					0	0	0	0	C	150767628	C	C	150767628	3	2	34	1	0	0	0	0	1	0	0	0	14718	1291	45	2	1572	2	SLC4A2	7	150767628	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	29353	150767628	8371035	204	6496											
DPP6	1804	broad.mit.edu	37	chr7	154561180	154561180	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctccggatggcacgagaCtcgcctacgccgccatcaat	8	7	11	15	5	2	1	1	0	1	1	4	3	2	2	4	3	1	1	4	3	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:154561180C>A	uc003wlk.2	+	9	1066	c.937C>A	c.(937-939)CTC>ATC	p.L313I	DPP6_uc003wli.2_Missense_Mutation_p.L249I|DPP6_uc003wlm.2_Missense_Mutation_p.L251I|DPP6_uc011kvq.1_Missense_Mutation_p.L206I	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	313	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TGGCACGAGACTCGCCTACGC	0.522													17	64					1.96292e-10	2.22132e-10	1	0	A	154561180	A	A	154561180	3	1	34	1	0	0	0	0	1	0	0	0	4752	565	20	4	1087	4	DPP6	7	154561180	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	3793552	154561180	4577483	205	6497											
DPP6	1804	broad.mit.edu	37	chr7	154679436	154679436	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccatggacttgacaacagaGcatacgaggtgtgtatgggc	11	9	13	8	1	0	2	0	1	0	1	1	4	1	3	1	3	3	2	1	3	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:154679436G>T	uc003wlk.2	+	23	2425	c.2296G>T	c.(2296-2298)GCA>TCA	p.A766S	DPP6_uc003wli.2_Missense_Mutation_p.A702S|DPP6_uc003wlm.2_Missense_Mutation_p.A704S|DPP6_uc011kvq.1_Missense_Mutation_p.A659S	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	766	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TGACAACAGAGCATACGAGGT	0.577													62	222					1.931e-44	2.72677e-44	1	0	T	154679436	T	T	154679436	3	4	34	1	0	0	0	0	1	0	0	0	4752	971	34	4	2502	4	DPP6	7	154679436	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	118256	154679436	4459227	206	6498											
PAXIP1	22976	broad.mit.edu	37	chr7	154738435	154738435	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccggaaagatggctgcttgGataacacctttcctcctgca	9	11	9	12	1	0	1	0	0	0	1	3	3	3	3	4	3	3	3	4	3	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:154738435G>T	uc003wlp.2	-	18	3054	c.3011C>A	c.(3010-3012)TCC>TAC	p.S1004Y	LOC100132707_uc011kvr.1_RNA|LOC100132707_uc003wlo.2_RNA|PAXIP1_uc003wlq.1_Missense_Mutation_p.S970Y|PAXIP1_uc011kvs.1_Missense_Mutation_p.S968Y	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	1004	Interaction with TP53BP1.|BRCT 6.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		TGGCTGCTTGGATAACACCTT	0.473													7	25					0.000157383	0.000163732	1	0	T	154738435	T	T	154738435	3	4	34	1	0	0	0	0	1	0	0	0	11541	1174	41	2	214	2	PAXIP1	7	154738435	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	58999	154738435	4400228	207	6499											
VIPR2	7434	broad.mit.edu	37	chr7	158896469	158896469	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgctctcatcctccgggtcGctgtagccacaggcatcgac	6	10	10	15	3	1	0	1	0	1	0	6	1	3	0	3	2	2	4	3	2	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr7:158896469G>C	uc003woh.2	-	4	522	c.336C>G	c.(334-336)AGC>AGG	p.S112R	VIPR2_uc010lqx.2_RNA|VIPR2_uc010lqy.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	112	Extracellular (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CCTCCGGGTCGCTGTAGCCAC	0.532													20	70					0	0	0	0	C	158896469	C	C	158896469	3	2	34	1	0	0	0	0	1	0	0	0	17238	1078	38	3	1020	3	VIPR2	7	158896469	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	4158034	158896469	242194	208	6500											
SOX17	64321	broad.mit.edu	37	chr8	55372293	55372293	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcaccagcaccacccccCgggccccggacagccgtcgc	7	1	10	23	4	0	0	0	0	0	0	1	1	0	1	9	2	3	2	9	2	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:55372293C>A	uc003xsb.3	+	2	1187	c.983C>A	c.(982-984)CCG>CAG	p.P328Q		NM_022454	NP_071899	Q9H6I2	SOX17_HUMAN	SRY-box 17	328	Gln/Pro-rich.|Sox C-terminal.				angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			lung(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			caccaCCCCCCGGGCCCCGGA	0.542													3	2					0.004672	0.00475942	1	0	A	55372293	A	A	55372293	3	1	34	1	0	0	0	0	1	0	0	0	15011	652	23	3	989	3	SOX17	8	55372293	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08		55372293	90991729	209	6501											
CHD7	55636	broad.mit.edu	37	chr8	61749499	61749499	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtacaagggcaggaggtttAggcattaacctcactgctgc	10	10	12	9	0	1	0	1	0	0	0	1	1	1	1	1	4	4	5	1	4	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:61749499A>G	uc003xue.2	+	17	4590	c.4113A>G	c.(4111-4113)TTA>TTG	p.L1371L		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1371	Helicase C-terminal.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CAGGAGGTTTAGGCATTAACC	0.483													44	121					0	0	0	0	G	61749499	G	G	61749499	2	3	34	1	0	0	0	0	0	0	0	1	3345	417	15	5		5	CHD7	8	61749499	Silent	SNP	A	TCGA-BB-7871-01A-11D-2229-08	6377206	61749499	84614523	210	6502											
RALYL	138046	broad.mit.edu	37	chr8	85799862	85799862	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagaagaagcaattggaaGagagtctagtgctgatccaa	15	8	11	7	0	2	4	1	1	1	3	3	6	3	5	1	1	2	2	1	1	6	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:85799862G>C	uc003ycq.3	+	9	1125	c.709G>C	c.(709-711)GAG>CAG	p.E237Q	RALYL_uc003ycr.3_Missense_Mutation_p.E237Q|RALYL_uc003ycs.3_Missense_Mutation_p.E237Q|RALYL_uc010lzy.2_Missense_Mutation_p.E226Q|RALYL_uc003yct.3_Missense_Mutation_p.E250Q|RALYL_uc003ycu.3_Missense_Mutation_p.E164Q|RALYL_uc003ycv.3_Intron	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	237	Potential.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						GCAATTGGAAGAGAGTCTAGT	0.483													36	81					0	0	0	0	C	85799862	C	C	85799862	3	2	34	1	0	0	0	0	1	0	0	0	13085	943	33	2	778	2	RALYL	8	85799862	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	24050363	85799862	60564160	211	6503											
CNGB3	54714	broad.mit.edu	37	chr8	87738761	87738761	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttttattaaatgctcacctGtttggaccttctttcccggg	6	17	8	10	1	2	0	1	0	1	0	3	1	3	1	3	2	1	3	3	2	3	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:87738761G>T	uc003ydx.2	-	3	382	c.336C>A	c.(334-336)AAC>AAA	p.N112K		NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	112	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						ATGCTCACCTGTTTGGACCTT	0.453													60	211					2.93687e-30	4.031e-30	1	0	T	87738761	T	T	87738761	3	4	34	1	0	0	0	0	1	0	0	0	3616	1368	48	4	2157	4	CNGB3	8	87738761	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1938899	87738761	58625261	212	6504											
DCAF4L2	138009	broad.mit.edu	37	chr8	88885094	88885094	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagcccccgaggcgagaaGagaaggccacactgggaatg	13	2	16	10	2	0	2	0	0	0	2	0	7	0	4	3	4	1	0	3	4	4	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:88885094G>T	uc003ydz.2	-	1	1203	c.1106C>A	c.(1105-1107)TCT>TAT	p.S369Y		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	369										ovary(1)	1						GAGGCGAGAAGAGAAGGCCAC	0.587													16	51					3.45872e-05	3.66041e-05	1	0	T	88885094	T	T	88885094	3	4	34	1	0	0	0	0	1	0	0	0	4289	942	33	2	85	2	DCAF4L2	8	88885094	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1146333	88885094	57478928	213	6505											
VPS13B	157680	broad.mit.edu	37	chr8	100443889	100443889	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagtgaagcatctcacactAcaggtaaaataaaagttaga	18	8	8	7	0	1	2	1	1	1	1	2	2	1	2	0	1	2	4	0	1	7	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:100443889A>T	uc003yiv.2	+	22	3318	c.3207A>T	c.(3205-3207)CTA>CTT	p.L1069L	VPS13B_uc003yiw.2_Silent_p.L1069L|VPS13B_uc003yiu.1_Silent_p.L1069L|VPS13B_uc003yix.1_Silent_p.L539L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1069					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATCTCACACTACAGGTAAAAT	0.299													13	34					0	0	0	0	T	100443889	T	T	100443889	2	4	34	1	0	0	0	0	0	0	0	1	17258	378	14	5		5	VPS13B	8	100443889	Silent	SNP	A	TCGA-BB-7871-01A-11D-2229-08	11558795	100443889	45920133	214	6506											
CSMD3	114788	broad.mit.edu	37	chr8	113585814	113585814	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatttgaagtactactaaGtgtcagtccgcgcatagatg	11	13	10	7	2	1	3	1	2	0	1	2	3	2	3	1	0	2	2	1	0	5	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:113585814G>T	uc003ynu.2	-	24	4117	c.3958C>A	c.(3958-3960)CTT>ATT	p.L1320I	CSMD3_uc003yns.2_Missense_Mutation_p.L592I|CSMD3_uc003ynt.2_Missense_Mutation_p.L1280I|CSMD3_uc011lhx.1_Missense_Mutation_p.L1216I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1320	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTACTACTAAGTGTCAGTCCG	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			49	132					3.37043e-27	4.54962e-27	1	0	T	113585814	T	T	113585814	3	4	34	1	0	0	0	0	1	0	0	0	3963	1029	36	4	7357	4	CSMD3	8	113585814	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	13141925	113585814	32778208	215	6507											
NOV	4856	broad.mit.edu	37	chr8	120435139	120435139	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacctgcagttcaagaacTgcaccagcctgcacacctac	11	7	6	17	0	1	1	1	0	0	1	2	1	2	1	5	0	6	4	5	0	3	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:120435139T>A	uc003yoq.2	+	5	1062	c.841T>A	c.(841-843)TGC>AGC	p.C281S		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	281	CTCK.				regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GTTCAAGAACTGCACCAGCCT	0.488													29	75					0	0	0	0	A	120435139	A	A	120435139	3	1	34	1	0	0	0	0	1	0	0	0	10607	1580	55	5	859	5	NOV	8	120435139	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	6849325	120435139	25928883	216	6508											
TAF2	6873	broad.mit.edu	37	chr8	120831623	120831623	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaaacttccaaggttgggtCattataaataaaagcagcct	16	10	7	8	0	1	0	1	0	0	0	2	0	2	0	2	2	3	2	2	2	7	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:120831623C>G	uc003you.2	-	3	532	c.262G>C	c.(262-264)GAC>CAC	p.D88H		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	88					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AAGGTTGGGTCATTATAAATA	0.318													38	168					0	0	0	0	G	120831623	G	G	120831623	3	3	34	1	0	0	0	0	1	0	0	0	15590	826	29	2	3433	2	TAF2	8	120831623	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	396484	120831623	25532399	217	6509											
FAM135B	51059	broad.mit.edu	37	chr8	139164215	139164215	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccctgctggttgtcagcatCtaaaactatctccaccaggg	9	10	9	13	0	3	0	1	0	2	0	4	0	3	0	3	2	3	3	3	2	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:139164215C>G	uc003yuy.2	-	13	2674	c.2503G>C	c.(2503-2505)GAT>CAT	p.D835H	FAM135B_uc003yux.2_Missense_Mutation_p.D736H|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.D397H|FAM135B_uc003yvb.2_Missense_Mutation_p.D397H	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	835										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTGTCAGCATCTAAAACTATC	0.527										HNSCC(54;0.14)			16	61					0	0	0	0	G	139164215	G	G	139164215	3	3	34	1	0	0	0	0	1	0	0	0	5477	913	32	2	1749	2	FAM135B	8	139164215	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	18332592	139164215	7199807	218	6510											
COL22A1	169044	broad.mit.edu	37	chr8	139737680	139737680	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gacaccagggggtcctggagGgccctgtagagaaagagcat	11	5	16	9	0	0	2	0	0	0	2	1	5	1	3	3	4	1	2	3	4	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:139737680G>T	uc003yvd.2	-	24	2590	c.2143C>A	c.(2143-2145)CCT>ACT	p.P715T	COL22A1_uc011ljo.1_Missense_Mutation_p.P15T	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	715	Collagen-like 5.|Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGTCCTGGAGGGCCCTGTAGA	0.577										HNSCC(7;0.00092)			24	66					9.80776e-20	1.24826e-19	1	0	T	139737680	T	T	139737680	3	4	34	1	0	0	0	0	1	0	0	0	3696	1232	43	4	2905	4	COL22A1	8	139737680	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	573465	139737680	6626342	219	6511											
CYP11B1	1584	broad.mit.edu	37	chr8	143957720	143957720	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcatctggcgacagttcCgcattcaacaggagctccgc	9	8	11	13	3	2	0	1	0	1	0	4	2	4	1	2	3	2	4	2	3	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:143957720C>T	uc003yxi.2	-	5	898	c.891G>A	c.(889-891)GCG>GCA	p.A297A	CYP11B1_uc010mex.2_5'Flank|CYP11B1_uc003yxh.2_5'UTR|CYP11B1_uc003yxj.2_Silent_p.A297A|CYP11B1_uc010mey.2_Silent_p.A368A	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	297					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GCGACAGTTCCGCATTCAACA	0.582									Familial_Hyperaldosteronism_type_I				17	55					0	0	0	0	T	143957720	T	T	143957720	2	4	34	1	0	0	0	0	0	0	0	1	4162	639	23	1		1	CYP11B1	8	143957720	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	4220040	143957720	2406302	220	6512											
PARP10	84875	broad.mit.edu	37	chr8	145058724	145058724	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcactcacccgaaagccagtCatatccggtccttcaagtgg	10	9	8	14	2	4	0	4	0	0	0	6	1	6	0	4	2	1	0	4	2	3	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:145058724C>A	uc003zal.3	-	5	1554	c.1446G>T	c.(1444-1446)ATG>ATT	p.M482I	PARP10_uc003zak.3_Missense_Mutation_p.M188I|PARP10_uc011lku.1_Missense_Mutation_p.M494I|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Missense_Mutation_p.M482I|PARP10_uc010mfn.1_Missense_Mutation_p.M397I|PARP10_uc010mfo.1_3'UTR	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	482						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAAAGCCAGTCATATCCGGTC	0.582													23	80					3.8784e-16	4.79904e-16	1	0	A	145058724	A	A	145058724	3	1	34	1	0	0	0	0	1	0	0	0	11509	826	29	2	1659	2	PARP10	8	145058724	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1101004	145058724	1305298	221	6513											
ZNF7	7553	broad.mit.edu	37	chr8	146068370	146068370	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctttgtgagccgtaaaaaGgttaatactataaagaaact	17	11	7	6	1	0	2	0	1	0	1	0	2	0	2	2	1	3	2	2	1	9	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr8:146068370G>A	uc003zeg.3	+	5	2015	c.1878G>A	c.(1876-1878)AAG>AAA	p.K626K	ZNF7_uc010mge.2_Silent_p.K637K|ZNF7_uc011lln.1_Silent_p.K530K|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Silent_p.K530K|COMMD5_uc003zel.1_Intron	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	626					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		GCCGTAAAAAGGTTAATACTA	0.433													17	49					0	0	0	0	A	146068370	A	A	146068370	2	1	34	1	0	0	0	0	0	0	0	1	18169	991	35	4		4	ZNF7	8	146068370	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1009646	146068370	295652	222	6514											
IL33	90865	broad.mit.edu	37	chr9	6252955	6252955	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggatgaaagttatgagAtatatgttgaagacttgaaa	16	12	12	1	0	0	5	0	4	0	2	0	8	0	7	0	2	0	2	0	2	6	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:6252955A>G	uc003zjt.2	+	5	490	c.433A>G	c.(433-435)ATA>GTA	p.I145V	IL33_uc011lmg.1_Intron|IL33_uc011lmh.1_Intron|IL33_uc003zju.1_Missense_Mutation_p.I145V	NM_033439	NP_254274	O95760	IL33_HUMAN	interleukin 33 precursor	145					positive regulation of chemokine secretion|positive regulation of inflammatory response|positive regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity				0		Acute lymphoblastic leukemia(23;0.158)|Prostate(43;0.167)		GBM - Glioblastoma multiforme(50;0.0161)|Lung(218;0.105)		AAGTTATGAGATATATGTTGA	0.264													8	15					0	0	0	0	G	6252955	G	G	6252955	3	3	34	1	0	0	0	0	1	0	0	0	7732	333	12	5	447	5	IL33	9	6252955	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08		6252955	134960476	223	6515											
LINGO2	158038	broad.mit.edu	37	chr9	27949502	27949502	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaatccttgaaagacctctCacggatggtgtctgggccag	10	9	12	10	1	2	2	1	1	2	1	4	4	3	3	3	3	0	0	3	3	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:27949502C>G	uc003zqu.1	-	2	1362	c.1168G>C	c.(1168-1170)GAG>CAG	p.E390Q	LINGO2_uc010mjf.1_Missense_Mutation_p.E390Q|LINGO2_uc003zqv.1_Missense_Mutation_p.E390Q	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	390	LRRCT.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		AAAGACCTCTCACGGATGGTG	0.507													18	51					0	0	0	0	G	27949502	G	G	27949502	3	3	34	1	0	0	0	0	1	0	0	0	8857	835	29	2	656	2	LINGO2	9	27949502	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	21696547	27949502	113263929	224	6516											
TLN1	7094	broad.mit.edu	37	chr9	35720872	35720872	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctgctccccttcagttgtCtgtactgagtaatagccatc	8	14	7	12	0	3	1	1	1	2	0	5	1	4	1	3	0	3	4	3	0	3	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:35720872C>G	uc003zxt.2	-	11	1497	c.1143G>C	c.(1141-1143)CAG>CAC	p.Q381H		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	381	FERM.|Interaction with LAYN (By similarity).				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTTCAGTTGTCTGTACTGAGT	0.493													20	86					0	0	0	0	G	35720872	G	G	35720872	3	3	34	1	0	0	0	0	1	0	0	0	16013	912	32	2	6670	2	TLN1	9	35720872	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	7771370	35720872	105492559	225	6517											
MELK	9833	broad.mit.edu	37	chr9	36677296	36677296	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcgatgcctgggtttacaaaAgattagtggaagacatccta	13	10	11	7	1	0	2	0	0	0	2	1	4	1	3	2	2	2	1	2	2	6	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:36677296A>T	uc003zzn.2	+	18	2056	c.1918A>T	c.(1918-1920)AGA>TGA	p.R640*	MELK_uc011lpm.1_Nonsense_Mutation_p.R509*|MELK_uc011lpn.1_Nonsense_Mutation_p.R599*|MELK_uc011lpo.1_Nonsense_Mutation_p.R446*|MELK_uc010mll.2_Nonsense_Mutation_p.R608*|MELK_uc011lpp.1_Nonsense_Mutation_p.R592*|MELK_uc010mlm.2_Nonsense_Mutation_p.R569*|MELK_uc011lpq.1_Nonsense_Mutation_p.R446*|MELK_uc011lpr.1_Nonsense_Mutation_p.R569*|MELK_uc011lps.1_Nonsense_Mutation_p.R560*	NM_014791	NP_055606	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	640	KA1.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			GGTTTACAAAAGATTAGTGGA	0.458													10	28					0	0	0	0	T	36677296	T	T	36677296	4	4	34	1	0	0	0	0	0	1	0	0	9523	64	3	5	1984	5	MELK	9	36677296	Nonsense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	956424	36677296	104536135	226	6518											
FRMPD1	22844	broad.mit.edu	37	chr9	37733514	37733514	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatatctccaactttactccGaaacatgaaaggcaaagaca	17	9	5	10	1	1	2	0	1	1	1	3	3	2	2	2	1	3	1	2	1	7	4	rs148144624		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:37733514G>A	uc004aag.1	+	11	1084	c.1040G>A	c.(1039-1041)CGA>CAA	p.R347Q	FRMPD1_uc004aah.1_Missense_Mutation_p.R347Q|FRMPD1_uc011lqm.1_Missense_Mutation_p.R169Q|FRMPD1_uc011lqn.1_Missense_Mutation_p.R216Q	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	347	FERM.					cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		ACTTTACTCCGAAACATGAAA	0.453													23	40					0	0	0	0	A	37733514	A	A	37733514	3	1	34	1	0	0	0	0	1	0	0	0	6091	1058	37	1	1078	1	FRMPD1	9	37733514	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1056218	37733514	103479917	227	6519											
IARS	3376	broad.mit.edu	37	chr9	95018990	95018990	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtctcaaagaagccaatGagagactgcatgaaggacag	16	6	11	8	0	2	4	2	2	1	2	3	6	2	5	1	1	2	1	1	1	4	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:95018990G>T	uc004art.1	-	20	2366	c.2109C>A	c.(2107-2109)CTC>CTA	p.L703L	IARS_uc004ars.1_Silent_p.L548L|IARS_uc004aru.3_Silent_p.L703L|IARS_uc010mqr.2_Silent_p.L593L|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	703					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	AGAAGCCAATGAGAGACTGCA	0.433													17	50					8.34094e-07	8.94324e-07	1	0	T	95018990	T	T	95018990	2	4	34	1	0	0	0	0	0	0	0	1	7512	1277	45	2		2	IARS	9	95018990	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	57285476	95018990	46194441	228	6520											
ANKS6	203286	broad.mit.edu	37	chr9	101540676	101540676	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatcagtttgagctttcGgaaccgattggacattcggt	8	13	11	9	3	1	1	1	1	0	0	3	4	1	3	1	3	3	3	1	3	1	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:101540676G>A	uc004ayu.2	-	7	1420	c.1399C>T	c.(1399-1401)CGA>TGA	p.R467*	ANKS6_uc004ayt.2_Nonsense_Mutation_p.R166*|ANKS6_uc004ayv.1_5'Flank|ANKS6_uc004ayw.1_Nonsense_Mutation_p.R49*|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	467										ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				TTGAGCTTTCGGAACCGATTG	0.587													9	23					0	0	0	0	A	101540676	A	A	101540676	4	1	34	1	0	0	0	0	0	1	0	0	692	1124	39	1	1252	1	ANKS6	9	101540676	Nonsense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	6521686	101540676	39672755	229	6521											
SVEP1	79987	broad.mit.edu	37	chr9	113208148	113208148	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcaggagcaaggtattgtCgctgccgttatcaactgcat	10	11	11	9	2	2	0	2	0	0	0	3	1	2	1	1	2	4	5	1	2	4	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:113208148C>A	uc010mtz.2	-	26	4769	c.4432G>T	c.(4432-4434)GAC>TAC	p.D1478Y	SVEP1_uc010mua.1_Missense_Mutation_p.D1478Y	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1478	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AAGGTATTGTCGCTGCCGTTA	0.453													32	117					6.29468e-14	7.54131e-14	1	0	A	113208148	A	A	113208148	3	1	34	1	0	0	0	0	1	0	0	0	15486	884	31	3	6375	3	SVEP1	9	113208148	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	11667472	113208148	28005283	230	6522											
SLC27A4	10999	broad.mit.edu	37	chr9	131107796	131107796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctcaccacctcgcgcgcacGggcccttgtctttggcagcg	4	8	11	18	5	2	0	1	0	1	0	3	0	2	0	4	2	1	2	4	2	0	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:131107796G>A	uc004but.2	+	3	808	c.524G>A	c.(523-525)CGG>CAG	p.R175Q	SLC27A4_uc004buu.2_Intron	NM_005094	NP_005085	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid	175					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding				0						TCGCGCGCACGGGCCCTTGTC	0.642													14	13					0	0	0	0	A	131107796	A	A	131107796	3	1	34	1	0	0	0	0	1	0	0	0	14592	1116	39	1	530	1	SLC27A4	9	131107796	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	17899648	131107796	10105635	231	6523											
SPTAN1	6709	broad.mit.edu	37	chr9	131365869	131365869	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccacctttaattccatcaaGgtaagaagcagtgaccagct	13	9	8	11	0	1	2	1	1	0	1	2	2	2	2	4	1	2	3	4	1	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:131365869G>A	uc004bvl.3	+	28	3740	c.3627G>A	c.(3625-3627)AAG>AAA	p.K1209K	SPTAN1_uc011mbh.1_Silent_p.K1221K|SPTAN1_uc004bvm.3_Silent_p.K1209K|SPTAN1_uc004bvn.3_Silent_p.K1189K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1209	Spectrin 13.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ATTCCATCAAGGTAAGAAGCA	0.493													33	129					0	0	0	0	A	131365869	A	A	131365869	2	1	34	1	0	0	0	0	0	0	0	1	15183	1014	35	4		4	SPTAN1	9	131365869	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	258073	131365869	9847562	232	6524											
BAT2L1	84726	broad.mit.edu	37	chr9	134351780	134351780	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctggccaagaggagcttcTccagtcagagacccgtggtt	9	8	13	11	1	2	2	1	0	1	2	3	4	2	3	3	3	2	3	3	3	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:134351780T>G	uc004can.3	+	15	4319	c.4264T>G	c.(4264-4266)TCC>GCC	p.S1422A	BAT2L1_uc010mzj.1_Missense_Mutation_p.S1005A|BAT2L1_uc004cao.3_Missense_Mutation_p.S780A	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1422							protein binding				0						GAGGAGCTTCTCCAGTCAGAG	0.652											OREG0019561	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	4					0	0	0	0	G	134351780	G	G	134351780	3	3	34	1	0	0	0	0	1	0	0	0	1322	1551	54	5	4322	5	BAT2L1	9	134351780	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	2985911	134351780	6861651	233	6525											
VAV2	7410	broad.mit.edu	37	chr9	136641200	136641200	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggcggccggctgatgggCggctggtggcagagcacaag	7	5	20	9	3	0	2	0	1	0	1	0	3	0	2	1	7	1	4	1	7	1	0	rs150295787		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr9:136641200C>A	uc004ces.2	-	24	2014	c.1968G>T	c.(1966-1968)CCG>CCT	p.P656P	VAV2_uc004cer.2_Silent_p.P646P|VAV2_uc004cet.1_Silent_p.P195P	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	656					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GGCTGATGGGCGGCTGGTGGC	0.617													22	70					7.92952e-12	9.20727e-12	1	0	A	136641200	A	A	136641200	2	1	34	1	0	0	0	0	0	0	0	1	17200	755	27	3		3	VAV2	9	136641200	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2289420	136641200	4572231	234	6526											
MLLT10	8028	broad.mit.edu	37	chr10	21962413	21962413	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actcccaacagtcatcagcaAccaaagatgtacataaagga	18	6	6	11	0	2	1	2	0	0	1	3	2	3	2	2	1	4	2	2	1	6	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:21962413A>T	uc001iqs.2	+	11	1534	c.1186A>T	c.(1186-1188)ACC>TCC	p.T396S	MLLT10_uc001iqt.2_Missense_Mutation_p.T396S|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.T396S|MLLT10_uc001ira.2_Intron|MLLT10_uc001irb.2_5'Flank|MLLT10_uc001iqz.2_Missense_Mutation_p.T151S	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	396	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						GTCATCAGCAACCAAAGATGT	0.458			T	MLL|PICALM|CDK6	AL								64	124					0	0	0	0	T	21962413	T	T	21962413	3	4	34	1	0	0	0	0	1	0	0	0	9679	43	2	5	1224	5	MLLT10	10	21962413	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08		21962413	113572334	235	6527											
ANKRD26	22852	broad.mit.edu	37	chr10	27375501	27375501	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagaagaatgtttaggtaTcctttcttctttatattctg	9	20	7	5	0	3	2	0	1	3	2	4	3	4	2	1	1	0	2	1	1	6	10			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:27375501T>C	uc001ith.2	-	5	848	c.676A>G	c.(676-678)ATA>GTA	p.I226V	ANKRD26_uc009xku.1_Missense_Mutation_p.I226V	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	226						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TGTTTAGGTATCCTTTCTTCT	0.264													15	60					0	0	0	0	C	27375501	C	C	27375501	3	2	34	1	0	0	0	0	1	0	0	0	654	1435	50	5	4576	5	ANKRD26	10	27375501	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	5413088	27375501	108159246	236	6528											
MKX	283078	broad.mit.edu	37	chr10	28023599	28023599	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgccacgtagtcctcactGgcccgtgactctggcctcac	5	9	11	16	2	3	1	2	1	1	0	4	1	4	1	4	3	1	1	4	3	1	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:28023599G>T	uc001ity.3	-	5	849	c.624C>A	c.(622-624)GCC>GCA	p.A208A	MKX_uc001itx.3_Silent_p.A208A	NM_173576	NP_775847	Q8IYA7	MKX_HUMAN	mohawk homeobox	208					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGTCCTCACTGGCCCGTGACT	0.502													27	105					1.77063e-15	2.17446e-15	1	0	T	28023599	T	T	28023599	2	4	34	1	0	0	0	0	0	0	0	1	9663	1335	47	4		4	MKX	10	28023599	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	648098	28023599	107511148	237	6529											
ARMC4	55130	broad.mit.edu	37	chr10	28260117	28260117	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttcctccaaaaattaatttgGttcttctccagtgacctttt	9	18	4	10	0	2	1	0	1	2	0	5	1	4	1	4	1	0	1	4	1	3	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:28260117G>T	uc009xky.2	-	8	1160	c.1062C>A	c.(1060-1062)AAC>AAA	p.N354K	ARMC4_uc010qds.1_Intron|ARMC4_uc010qdt.1_Missense_Mutation_p.N46K|ARMC4_uc001itz.2_Missense_Mutation_p.N354K|ARMC4_uc010qdu.1_Missense_Mutation_p.N46K	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	354							binding			ovary(4)|skin(2)	6						AATTAATTTGGTTCTTCTCCA	0.413													26	104					4.87955e-14	5.86025e-14	1	0	T	28260117	T	T	28260117	3	4	34	1	0	0	0	0	1	0	0	0	955	1252	44	4	2124	4	ARMC4	10	28260117	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	236518	28260117	107274630	238	6530											
ZEB1	6935	broad.mit.edu	37	chr10	31809695	31809695	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaattatcatcaactacAgtcttgagcagcctagccaa	15	9	5	12	0	3	1	2	1	1	0	3	1	3	1	3	0	5	1	3	0	7	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:31809695A>C	uc001ivs.3	+	7	1495	c.1432A>C	c.(1432-1434)AGT>CGT	p.S478R	ZEB1_uc001ivr.3_Missense_Mutation_p.S260R|ZEB1_uc010qee.1_Missense_Mutation_p.S260R|ZEB1_uc010qef.1_Missense_Mutation_p.S260R|ZEB1_uc009xlj.1_Missense_Mutation_p.S404R|ZEB1_uc010qeg.1_Missense_Mutation_p.S337R|ZEB1_uc009xlk.1_Missense_Mutation_p.S260R|ZEB1_uc001ivt.3_Missense_Mutation_p.S260R|ZEB1_uc001ivu.3_Missense_Mutation_p.S479R|ZEB1_uc001ivv.3_Missense_Mutation_p.S458R|ZEB1_uc010qeh.1_Missense_Mutation_p.S411R|ZEB1_uc009xlo.1_Missense_Mutation_p.S461R|ZEB1_uc009xlp.2_Missense_Mutation_p.S462R	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	478					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				CATCAACTACAGTCTTGAGCA	0.378													20	50					0	0	0	0	C	31809695	C	C	31809695	3	2	34	1	0	0	0	0	1	0	0	0	17690	188	7	5	1472	5	ZEB1	10	31809695	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	3549578	31809695	103725052	239	6531											
ZEB1	6935	broad.mit.edu	37	chr10	31812949	31812949	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accgcccaaaaagaaaatgcGgaagacagaaaatggaatgt	20	4	10	7	2	0	3	0	0	0	3	0	5	0	5	2	2	1	0	2	2	8	0	rs35653460		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:31812949G>T	uc001ivs.3	+	8	2753	c.2690G>T	c.(2689-2691)CGG>CTG	p.R897L	ZEB1_uc001ivr.3_Missense_Mutation_p.R679L|ZEB1_uc010qee.1_Missense_Mutation_p.R679L|ZEB1_uc010qef.1_Missense_Mutation_p.R679L|ZEB1_uc009xlk.1_Missense_Mutation_p.R679L|ZEB1_uc001ivt.3_Missense_Mutation_p.R679L|ZEB1_uc001ivu.3_Missense_Mutation_p.R898L|ZEB1_uc001ivv.3_Missense_Mutation_p.R877L|ZEB1_uc010qeh.1_Missense_Mutation_p.R830L|ZEB1_uc009xlp.2_Missense_Mutation_p.R881L	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	897					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				AAGAAAATGCGGAAGACAGAA	0.373													27	97					2.61193e-14	3.16012e-14	1	0	T	31812949	T	T	31812949	3	4	34	1	0	0	0	0	1	0	0	0	17690	1116	39	3	2734	3	ZEB1	10	31812949	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	3254	31812949	103721798	240	6532											
ITGB1	3688	broad.mit.edu	37	chr10	33199265	33199265	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgggacacaggatcaggttGgaccggctggggtaatttgt	9	10	16	6	1	1	0	1	0	0	0	1	3	1	3	1	7	0	3	1	7	1	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:33199265G>A	uc001iws.3	-	14	2186	c.2050C>T	c.(2050-2052)CAA>TAA	p.Q684*	ITGB1_uc001iwp.3_Nonsense_Mutation_p.Q684*|ITGB1_uc001iwq.3_Nonsense_Mutation_p.Q684*|ITGB1_uc001iwr.3_Nonsense_Mutation_p.Q684*|ITGB1_uc001iwt.3_Nonsense_Mutation_p.Q684*|ITGB1_uc001iwu.1_Nonsense_Mutation_p.Q684*	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	684	Extracellular (Potential).				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				GGATCAGGTTGGACCGGCTGG	0.428													17	36					0	0	0	0	A	33199265	A	A	33199265	4	1	34	1	0	0	0	0	0	1	0	0	7929	1357	47	4	596	4	ITGB1	10	33199265	Nonsense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1386316	33199265	102335482	241	6533											
PARD3	56288	broad.mit.edu	37	chr10	34805969	34805969	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttggtaaggctgaaaggctGagacattgttggtgccaagc	10	10	14	7	0	0	2	0	2	0	1	0	3	0	2	1	4	2	4	1	4	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:34805969G>C	uc010qej.1	-	3	341	c.341C>G	c.(340-342)TCA>TGA	p.S114*	PARD3_uc010qek.1_Nonsense_Mutation_p.S114*|PARD3_uc010qel.1_Nonsense_Mutation_p.S114*|PARD3_uc010qem.1_Nonsense_Mutation_p.S114*|PARD3_uc010qen.1_Nonsense_Mutation_p.S114*|PARD3_uc010qeo.1_Nonsense_Mutation_p.S114*|PARD3_uc010qep.1_Nonsense_Mutation_p.S114*|PARD3_uc010qeq.1_Nonsense_Mutation_p.S114*|PARD3_uc001ixp.1_5'UTR|PARD3_uc001ixq.1_Nonsense_Mutation_p.S114*|PARD3_uc001ixr.1_Nonsense_Mutation_p.S114*|PARD3_uc001ixt.1_5'UTR|PARD3_uc001ixu.1_Nonsense_Mutation_p.S114*	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	114					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CTGAAAGGCTGAGACATTGTT	0.488													19	43					0	0	0	0	C	34805969	C	C	34805969	4	2	34	1	0	0	0	0	0	1	0	0	11497	1294	45	2	3856	2	PARD3	10	34805969	Nonsense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1606704	34805969	100728778	242	6534											
PCDH15	65217	broad.mit.edu	37	chr10	55568483	55568483	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttgtaaccttcagagtttGctcctggcgacttcttttgg	5	17	10	9	1	2	1	1	0	1	1	3	2	3	1	2	2	2	4	2	2	1	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:55568483G>A	uc010qhs.1	-	37	5737	c.5342C>T	c.(5341-5343)GCA>GTA	p.A1781V	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Missense_Mutation_p.A1774V|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTCAGAGTTTGCTCCTGGCGA	0.478										HNSCC(58;0.16)			7	17					0	0	0	0	A	55568483	A	A	55568483	3	1	34	1	0	0	0	0	1	0	0	0	11565	1319	46	4	589	4	PCDH15	10	55568483	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	20762514	55568483	79966264	243	6535											
GRID1	2894	broad.mit.edu	37	chr10	87362282	87362282	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggcagaaaggtgctgacCgagagctgggtgttctggta	8	10	16	7	1	2	3	0	1	2	2	2	4	2	3	1	4	2	5	1	4	2	2	rs3750689		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:87362282C>G	uc001kdl.1	-	16	2879	c.2778G>C	c.(2776-2778)TCG>TCC	p.S926S	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Silent_p.S497S|uc001kdk.1_Intron	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	926	Cytoplasmic (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGGTGCTGACCGAGAGCTGGG	0.657										Multiple Myeloma(13;0.14)			13	45					0	0	0	0	G	87362282	G	G	87362282	2	3	34	1	0	0	0	0	0	0	0	1	6810	639	23	3		3	GRID1	10	87362282	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	31793799	87362282	48172465	244	6536											
MGMT	4255	broad.mit.edu	37	chr10	131565174	131565174	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccaccggttggggaagccAggcttgggagggagctcagg	7	5	20	9	1	1	0	1	0	0	0	1	3	1	3	3	8	2	3	3	8	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:131565174A>T	uc001lkh.2	+	5	656	c.630A>T	c.(628-630)CCA>CCT	p.P210P		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	179										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		TGGGGAAGCCAGGCTTGGGAG	0.652								Direct_reversal_of_damage					11	40					0	0	0	0	T	131565174	T	T	131565174	2	4	34	1	0	0	0	0	0	0	0	1	9610	175	7	5		5	MGMT	10	131565174	Silent	SNP	A	TCGA-BB-7871-01A-11D-2229-08	44202892	131565174	3969573	245	6537											
DPYSL4	10570	broad.mit.edu	37	chr10	134006226	134006226	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgacgcccacggcctgatgGtccttcctggtggcgttgac	4	11	13	13	3	0	3	0	3	0	0	2	3	2	3	4	4	0	1	4	4	0	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:134006226G>A	uc009ybb.2	+	3	347	c.193G>A	c.(193-195)GTC>ATC	p.V65I		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	65					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CGGCCTGATGGTCCTTCCTGG	0.582													17	69					0	0	0	0	A	134006226	A	A	134006226	3	1	34	1	0	0	0	0	1	0	0	0	4771	1261	44	4	203	4	DPYSL4	10	134006226	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2441052	134006226	1528521	246	6538											
GPR123	84435	broad.mit.edu	37	chr10	134942302	134942302	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgggcatgctgcccgcccCgcaaggacgcccaccccgca	6	3	13	19	4	0	0	0	0	0	0	0	1	0	1	6	3	2	4	6	3	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr10:134942302C>A	uc001llx.3	+	7	1406	c.970C>A	c.(970-972)CGC>AGC	p.R324S	GPR123_uc001llw.2_Missense_Mutation_p.R1043S	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	324	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CTGCCCGCCCCGCAAGGACGC	0.726													19	30					0.00188189	0.00192913	1	0	A	134942302	A	A	134942302	3	1	34	1	0	0	0	0	1	0	0	0	6675	652	23	3	992	3	GPR123	10	134942302	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	936076	134942302	592445	247	6539											
KCNQ1	3784	broad.mit.edu	37	chr11	2604772	2604772	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctccttctttgcgctcccAgcggtaggtgccccgtgggt	3	12	12	14	3	2	0	0	0	2	0	4	0	3	0	4	3	3	2	4	3	1	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:2604772A>T	uc001lwn.2	+	7	1137	c.1029A>T	c.(1027-1029)CCA>CCT	p.P343P	KCNQ1_uc009ydp.1_Silent_p.P127P|KCNQ1_uc001lwo.2_Silent_p.P216P	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	343	Helical; Name=Segment S6; (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	TTGCGCTCCCAGCGGTAGGTG	0.632													29	86					0	0	0	0	T	2604772	T	T	2604772	2	4	34	1	0	0	0	0	0	0	0	1	8121	175	7	5		5	KCNQ1	11	2604772	Silent	SNP	A	TCGA-BB-7871-01A-11D-2229-08		2604772	132401744	248	6540											
OR51B6	390058	broad.mit.edu	37	chr11	5373442	5373442	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggaggagaaagggccaaggcCctcaacacatgtgtctctca	12	6	12	11	0	3	1	2	0	1	1	4	3	3	2	2	4	1	0	2	4	3	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:5373442C>G	uc010qzb.1	+	1	705	c.705C>G	c.(703-705)GCC>GCG	p.A235A	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGCCAAGGCCCTCAACACAT	0.428													37	88					0	0	0	0	G	5373442	G	G	5373442	2	3	34	1	0	0	0	0	0	0	0	1	11146	610	22	4		4	OR51B6	11	5373442	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2768670	5373442	129633074	249	6541											
TRIM6-TRIM34	445372	broad.mit.edu	37	chr11	5624484	5624484	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatctacctaggattctacAggcaggaaacatcttagaaa	15	10	7	9	0	4	1	1	0	3	1	4	3	4	3	1	3	3	1	1	3	6	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:5624484A>T	uc001mbf.2	+	2	270	c.26A>T	c.(25-27)CAG>CTG	p.Q9L	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_5'UTR|TRIM6_uc010qzj.1_Intron|TRIM6_uc001mbc.1_5'UTR|TRIM6_uc001mbe.2_Intron|TRIM6_uc010qzk.1_Intron|TRIM6_uc010qzl.1_Intron|TRIM6_uc001mbd.2_Missense_Mutation_p.Q9L|TRIM6_uc001mbg.1_5'Flank|TRIM6_uc009yep.1_5'Flank	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	9						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		AGGATTCTACAGGCAGGAAAC	0.473													11	28					0	0	0	0	T	5624484	T	T	5624484	3	4	34	1	0	0	0	0	1	0	0	0	16601	188	7	5	32	5	TRIM6-TRIM34	11	5624484	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	251042	5624484	129382032	250	6542											
OR56B4	196335	broad.mit.edu	37	chr11	6129115	6129115	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagcactggctctccctgcCcctgactctgctctacctct	4	11	7	19	0	4	1	0	1	4	0	5	1	4	1	4	1	4	4	4	1	1	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:6129115C>A	uc010qzx.1	+	1	107	c.107C>A	c.(106-108)CCC>CAC	p.P36H		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCTCCCTGCCCCTGACTCTG	0.507													24	68					5.60225e-13	6.6147e-13	1	0	A	6129115	A	A	6129115	3	1	34	1	0	0	0	0	1	0	0	0	11192	623	22	4	109	4	OR56B4	11	6129115	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	504631	6129115	128877401	251	6543											
CCKBR	887	broad.mit.edu	37	chr11	6292696	6292696	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccccagggctcttcccgatGaggaccctcccactccctcc	5	7	8	21	1	1	1	0	1	1	0	5	3	5	2	7	2	0	1	7	2	0	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:6292696G>C	uc001mcp.2	+	5	1460	c.1267G>C	c.(1267-1269)GAG>CAG	p.E423Q	CCKBR_uc001mcq.2_Missense_Mutation_p.E351Q|CCKBR_uc001mcr.2_Missense_Mutation_p.E406Q|CCKBR_uc001mcs.2_Missense_Mutation_p.E492Q	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	423	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TCTTCCCGATGAGGACCCTCC	0.652													26	59					0	0	0	0	C	6292696	C	C	6292696	3	2	34	1	0	0	0	0	1	0	0	0	2894	1291	45	2	1285	2	CCKBR	11	6292696	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	163581	6292696	128713820	252	6544											
RBMXL2	27288	broad.mit.edu	37	chr11	7111450	7111450	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagcgtgattcttacagcCggtcaggctgcagggtgccc	6	8	13	14	2	2	1	1	1	1	0	2	1	2	1	3	3	5	2	3	3	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:7111450C>T	uc001mfc.2	+	1	1286	c.1099C>T	c.(1099-1101)CGG>TGG	p.R367W		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	367	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTCTTACAGCCGGTCAGGCTG	0.657													4	12					0	0	0	0	T	7111450	T	T	7111450	3	4	34	1	0	0	0	0	1	0	0	0	13219	643	23	1	1101	1	RBMXL2	11	7111450	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	818754	7111450	127895066	253	6545											
MRVI1	10335	broad.mit.edu	37	chr11	10647888	10647888	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccgttttcaagagctgcttCcccagctcgctctccacggg	5	10	9	17	3	2	1	1	0	1	1	5	1	3	1	4	1	3	5	4	1	1	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:10647888C>T	uc010rcc.1	-	9	1379	c.993G>A	c.(991-993)GGG>GGA	p.G331G	MRVI1_uc001miw.2_Silent_p.G322G|MRVI1_uc010rcb.1_Silent_p.G323G|MRVI1_uc009ygb.1_Silent_p.G16G|MRVI1_uc001mix.2_Silent_p.G16G|MRVI1_uc001miz.2_Silent_p.G240G|MRVI1_uc009ygc.1_Silent_p.G240G|MRVI1_uc010rcd.1_Intron|MRVI1_uc009ygd.1_Silent_p.G16G|MRVI1_uc010rce.1_Intron	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	304					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		AGAGCTGCTTCCCCAGCTCGC	0.647													6	21					0	0	0	0	T	10647888	T	T	10647888	2	4	34	1	0	0	0	0	0	0	0	1	9906	842	30	2		2	MRVI1	11	10647888	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	3536438	10647888	124358628	254	6546											
CTR9	9646	broad.mit.edu	37	chr11	10772990	10772991	+	Frame_Shift_Ins	INS	-	G	G																															ctccatcgagattcccctccINSgggacactgacgaggtaagt																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:10772990_10772991insG	uc001mja.2	+	1	180_181	c.31_32insG	c.(31-33)CGGfs	p.R11fs		NM_014633	NP_055448	Q6PD62	CTR9_HUMAN	SH2 domain binding protein 1	11					histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				ovary(2)	2				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GATTCCCCTCCGGGACACTGAC	0.619													---	---	---								G	10772991	G	G	10772990	7	5	34	1	0	1	1	0	0	0	0	0	4041	643	23	0	33	0	CTR9	11	10772990	Frame_Shift_Ins	INS	-	TCGA-BB-7871-01A-11D-2229-08	125102	10772990	124233526	255	6547											
HPS5	11234	broad.mit.edu	37	chr11	18313218	18313219	+	Frame_Shift_Ins	INS	-	A	A																															ataatgttgtcaattcagccINSaggtcgttccgaagaccact																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:18313218_18313219insA	uc001mod.1	-	16	2488_2489	c.2210_2211insT	c.(2209-2211)CTGfs	p.L737fs	HPS5_uc001moe.1_Frame_Shift_Ins_p.L623fs|HPS5_uc001mof.1_Frame_Shift_Ins_p.L623fs	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	737						cytosol				ovary(1)|pancreas(1)|skin(1)	3						TCAATTCAGCCAGGTCGTTCCG	0.431									Hermansky-Pudlak_syndrome				---	---	---								A	18313219	A	A	18313218	7	5	34	1	0	1	1	0	0	0	0	0	7381	581	21	0	1210	0	HPS5	11	18313218	Frame_Shift_Ins	INS	-	TCGA-BB-7871-01A-11D-2229-08	7540228	18313218	116693298	256	6548											
IGSF22	283284	broad.mit.edu	37	chr11	18741340	18741340	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgaaaccatactccatgcAcaccttctcaaagtctttct	11	12	5	13	0	3	1	1	1	3	0	5	1	4	1	3	1	3	1	3	1	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:18741340A>T	uc009yht.2	-	7	809	c.619T>A	c.(619-621)TGC>AGC	p.C207S	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	207	Lys-rich.									ovary(4)|large_intestine(2)|kidney(1)	7						TACTCCATGCACACCTTCTCA	0.507													64	207					0	0	0	0	T	18741340	T	T	18741340	3	4	34	1	0	0	0	0	1	0	0	0	7639	159	6	5	3429	5	IGSF22	11	18741340	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	428122	18741340	116265176	257	6549											
KCNA4	3739	broad.mit.edu	37	chr11	30033372	30033373	+	Missense_Mutation	DNP	GG	TT	TT																															gctttttaaattcattctcgGggagggccctgtcttcctct																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:30033372_30033373GG>TT	uc001msk.2	-	2	2005_2006	c.853_854CC>AA	c.(853-855)CCC>AAC	p.P285N		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	285						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TTCATTCTCGGGGAGGGCCCTG	0.515													14	34					0	0	0	0	TT	30033373	TT	TT	30033372	3	4	34	1	0	0	0	0	1	0	0	0	8044	1232	43	4	1111	4	KCNA4	11	30033372	Missense_Mutation	DNP	GG	TCGA-BB-7871-01A-11D-2229-08	11292032	30033372	104973144	258	6550											
OR4A15	81328	broad.mit.edu	37	chr11	55135910	55135910	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattggaggctttcttcactCattggttcaatttctcttta	7	19	7	8	0	5	0	3	0	2	0	6	2	5	1	0	3	0	2	0	3	2	8			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:55135910C>A	uc010rif.1	+	1	551	c.551C>A	c.(550-552)TCA>TAA	p.S184*		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	184	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTTCTTCACTCATTGGTTCAA	0.428													45	141					2.77807e-22	3.63972e-22	1	0	A	55135910	A	A	55135910	4	1	34	1	0	0	0	0	0	1	0	0	11094	838	29	2	553	2	OR4A15	11	55135910	Nonsense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	25102538	55135910	79870606	259	6551											
OR5D16	390144	broad.mit.edu	37	chr11	55606889	55606889	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catcattctgacatcttatgCattcatcattgtcaccacct	10	15	3	13	0	6	1	4	1	2	0	6	1	6	1	2	0	1	1	2	0	1	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:55606889C>T	uc010rio.1	+	1	662	c.662C>T	c.(661-663)GCA>GTA	p.A221V		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				ACATCTTATGCATTCATCATT	0.468													23	80					0	0	0	0	T	55606889	T	T	55606889	3	4	34	1	0	0	0	0	1	0	0	0	11210	710	25	4	664	4	OR5D16	11	55606889	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	470979	55606889	79399627	260	6552											
OR5M1	390168	broad.mit.edu	37	chr11	56380683	56380683	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgaagagaagacactgtGtgaagcatccagcgtaggag	14	6	14	7	2	0	4	0	2	0	2	1	7	1	5	1	1	2	2	1	1	4	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:56380683G>T	uc001nja.1	-	1	296	c.296C>A	c.(295-297)ACA>AAA	p.T99K		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AAGACACTGTGTGAAGCATCC	0.443													24	87					0.000147802	0.000154091	1	0	T	56380683	T	T	56380683	3	4	34	1	0	0	0	0	1	0	0	0	11226	1377	48	4	655	4	OR5M1	11	56380683	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	773794	56380683	78625833	261	6553											
LRRC55	219527	broad.mit.edu	37	chr11	56954744	56954744	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagctggctgagtgccggggCcctcctgaagtcgagggcgc	5	6	17	13	3	0	2	0	2	0	0	2	3	1	2	3	4	2	2	3	4	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:56954744C>A	uc001njl.1	+	2	963	c.816C>A	c.(814-816)GGC>GGA	p.G272G	LRRC55_uc001njm.1_5'Flank	NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	242	LRRCT.					integral to membrane					0						AGTGCCGGGGCCCTCCTGAAG	0.587													35	124					3.09479e-21	4.0224e-21	1	0	A	56954744	A	A	56954744	2	1	34	1	0	0	0	0	0	0	0	1	9061	726	26	4		4	LRRC55	11	56954744	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	574061	56954744	78051772	262	6554											
CTNND1	1500	broad.mit.edu	37	chr11	57578936	57578936	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgatagtactctccctctCattgaccggaaccaaaaatc	13	10	6	12	1	2	2	1	2	2	0	5	4	2	3	3	1	2	1	3	1	5	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:57578936C>G	uc001nmc.3	+	17	3187	c.2616C>G	c.(2614-2616)CTC>CTG	p.L872L	CTNND1_uc001nlh.1_Silent_p.L872L|CTNND1_uc001nlu.3_Silent_p.L765L|CTNND1_uc001nlt.3_Silent_p.L765L|CTNND1_uc001nls.3_Silent_p.L765L|CTNND1_uc001nlw.3_Silent_p.L765L|CTNND1_uc001nmf.3_Silent_p.L872L|CTNND1_uc001nmd.3_Silent_p.L818L|CTNND1_uc001nlk.3_Silent_p.L818L|CTNND1_uc001nme.3_Silent_p.L866L|CTNND1_uc001nll.3_Silent_p.L812L|CTNND1_uc001nmg.3_Silent_p.L812L|CTNND1_uc001nlj.3_Silent_p.L812L|CTNND1_uc001nlr.3_Silent_p.L812L|CTNND1_uc001nlp.3_Silent_p.L812L|CTNND1_uc001nlx.3_Silent_p.L549L|CTNND1_uc001nlz.3_Silent_p.L549L|CTNND1_uc009ymn.2_Silent_p.L543L|CTNND1_uc001nlm.3_Silent_p.L866L|CTNND1_uc001nly.3_Silent_p.L543L|CTNND1_uc001nmb.3_Silent_p.L543L|CTNND1_uc001nma.3_Silent_p.L543L|CTNND1_uc001nmi.3_Silent_p.L771L|CTNND1_uc001nmh.3_Silent_p.L866L|CTNND1_uc001nlq.3_Silent_p.L771L|CTNND1_uc001nln.3_Silent_p.L866L|CTNND1_uc001nli.3_Silent_p.L866L|CTNND1_uc001nlo.3_Silent_p.L765L|CTNND1_uc001nlv.3_Silent_p.L765L	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	872					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				CTCTCCCTCTCATTGACCGGA	0.438													54	173					0	0	0	0	G	57578936	G	G	57578936	2	3	34	1	0	0	0	0	0	0	0	1	4036	813	29	2		2	CTNND1	11	57578936	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	624192	57578936	77427580	263	6555											
LPXN	9404	broad.mit.edu	37	chr11	58295529	58295529	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacagaccccacaaacaaagCactctgggtgccagacagtg	14	5	9	13	0	1	2	0	0	1	2	1	2	1	2	3	1	4	1	3	1	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:58295529C>A	uc001nmw.2	-	8	1023	c.878G>T	c.(877-879)TGC>TTC	p.C293F	LPXN_uc009ymp.2_Missense_Mutation_p.C163F|LPXN_uc010rkj.1_Missense_Mutation_p.C298F|LPXN_uc010rkk.1_Missense_Mutation_p.C273F	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2	293	LIM zinc-binding 3.				cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				ACAAACAAAGCACTCTGGGTG	0.483													17	65					6.33239e-15	7.69943e-15	1	0	A	58295529	A	A	58295529	3	1	34	1	0	0	0	0	1	0	0	0	8979	710	25	4	290	4	LPXN	11	58295529	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	716593	58295529	76710987	264	6556											
MS4A14	84689	broad.mit.edu	37	chr11	60183000	60183000	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaatttgtgcttcaagaaGagttttccagtgatgattca	12	15	8	6	0	2	4	2	2	0	2	3	4	3	4	1	0	2	2	1	0	4	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:60183000G>T	uc001npj.2	+	5	1124	c.559G>T	c.(559-561)GAG>TAG	p.E187*	MS4A14_uc001npi.2_Nonsense_Mutation_p.E75*|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Nonsense_Mutation_p.E170*|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	187						integral to membrane	receptor activity			breast(1)	1						GCTTCAAGAAGAGTTTTCCAG	0.378													22	60					2.37509e-13	2.81791e-13	1	0	T	60183000	T	T	60183000	4	4	34	1	0	0	0	0	0	1	0	0	9911	943	33	2	577	2	MS4A14	11	60183000	Nonsense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1887471	60183000	74823516	265	6557											
RPS6KA4	8986	broad.mit.edu	37	chr11	64137046	64137046	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgtgtcggccgtgagcttCatgcacgaggaggcgggcgt	5	8	17	11	6	1	1	1	1	0	0	3	3	1	2	1	4	2	2	1	4	0	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:64137046C>A	uc001oae.2	+	13	1640	c.1557C>A	c.(1555-1557)TTC>TTA	p.F519L	RPS6KA4_uc001oad.2_Missense_Mutation_p.F513L|RPS6KA4_uc010rnl.1_Missense_Mutation_p.F456L|RPS6KA4_uc001oaf.2_Missense_Mutation_p.F512L|RPS6KA4_uc009ypp.2_Intron	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	519	Protein kinase 2.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						CCGTGAGCTTCATGCACGAGG	0.721													4	13					0.00909568	0.0092275	1	0	A	64137046	A	A	64137046	3	1	34	1	0	0	0	0	1	0	0	0	13718	825	29	2	1607	2	RPS6KA4	11	64137046	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	3954046	64137046	70869470	266	6558											
ARL2	402	broad.mit.edu	37	chr11	64786169	64786169	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccgccagcgcatgcaggaCtgccagcgggagctccagag	9	3	15	14	3	0	1	0	0	0	1	1	4	1	3	4	2	5	3	4	2	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:64786169C>G	uc001och.3	+	3	397	c.303C>G	c.(301-303)GAC>GAG	p.D101E	ARL2_uc010rnu.1_Missense_Mutation_p.D101E|SNX15_uc001oci.3_5'UTR	NM_001667	NP_001658	P36404	ARL2_HUMAN	ADP-ribosylation factor-like 2	101					cell cycle|centrosome organization|maintenance of protein location in nucleus|negative regulation of GTPase activity|positive regulation of cell-substrate adhesion|positive regulation of microtubule polymerization|small GTPase mediated signal transduction|tight junction assembly|tubulin complex assembly	centrosome|lateral plasma membrane|mitochondrial intermembrane space|nucleus	GTP binding|GTPase activity|GTPase inhibitor activity|protein binding				0						GCATGCAGGACTGCCAGCGGG	0.617													9	32					0	0	0	0	G	64786169	G	G	64786169	3	3	34	1	0	0	0	0	1	0	0	0	935	564	20	4	313	4	ARL2	11	64786169	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	649123	64786169	70220347	267	6559											
PPFIA1	8500	broad.mit.edu	37	chr11	70194407	70194407	+	Frame_Shift_Del	DEL	C	-	-																															ttagatcaatgagctccattCccccctaccctgcttcctcg																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:70194407delC	uc001opo.2	+	16	2242	c.2044delC	c.(2044-2046)CCCfs	p.P682fs	PPFIA1_uc001opn.1_Frame_Shift_Del_p.P682fs|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	682					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			GAGCTCCATTCCCCCCTACCC	0.557													---	---	---								-	70194407	-	-	70194407	7	5	34	1	0	1	0	1	0	0	0	0	12364	855	30	0	2102	0	PPFIA1	11	70194407	Frame_Shift_Del	DEL	C	TCGA-BB-7871-01A-11D-2229-08	5408238	70194407	64812109	268	6560											
PAAF1	80227	broad.mit.edu	37	chr11	73625542	73625542	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgcttgggactacagagcaGgcagctggcaagtggttcct	8	9	15	9	0	0	1	0	0	0	1	1	2	1	2	1	4	4	6	1	4	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:73625542G>T	uc001ouk.1	+	8	846	c.812G>T	c.(811-813)AGG>ATG	p.R271M	PAAF1_uc001oul.1_Missense_Mutation_p.R254M|PAAF1_uc009ytx.1_RNA|PAAF1_uc001oum.1_Missense_Mutation_p.R254M	NM_025155	NP_079431	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	271					interspecies interaction between organisms	proteasome complex	protein binding			ovary(1)|skin(1)	2	Breast(11;7.42e-05)					CTACAGAGCAGGCAGCTGGCA	0.478													15	74					2.62699e-14	3.16271e-14	1	0	T	73625542	T	T	73625542	3	4	34	1	0	0	0	0	1	0	0	0	11416	1000	35	4	842	4	PAAF1	11	73625542	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	3431135	73625542	61380974	269	6561											
LRRC32	2615	broad.mit.edu	37	chr11	76372274	76372274	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaggtcacgcgtggcaggggGcccaggccaccagcactcag	8	3	16	14	2	2	0	2	0	0	0	2	1	2	0	3	5	1	2	3	5	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:76372274G>A	uc001oxq.3	-	3	606	c.363C>T	c.(361-363)GGC>GGT	p.G121G	LRRC32_uc001oxr.3_Silent_p.G121G|LRRC32_uc010rsf.1_Silent_p.G121G	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	121	Extracellular (Potential).					integral to plasma membrane					0						GTGGCAGGGGGCCCAGGCCAC	0.692													33	61					0	0	0	0	A	76372274	A	A	76372274	2	1	34	1	0	0	0	0	0	0	0	1	9037	1190	42	4		4	LRRC32	11	76372274	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2746732	76372274	58634242	270	6562											
MTMR2	8898	broad.mit.edu	37	chr11	95582947	95582947	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atttttcatcttctttgcttCgctttccactcactccaacc	6	18	2	15	1	4	0	2	0	2	0	7	0	6	0	3	0	2	2	3	0	1	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:95582947C>T	uc001pfu.2	-	9	1137	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	MTMR2_uc001pfv.2_Missense_Mutation_p.R223Q|MTMR2_uc001pfs.2_Missense_Mutation_p.R223Q|MTMR2_uc001pft.2_Missense_Mutation_p.R223Q|MTMR2_uc010ruj.1_Missense_Mutation_p.R278Q	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	295	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TTCTTTGCTTCGCTTTCCACT	0.413													53	76					0	0	0	0	T	95582947	T	T	95582947	3	4	34	1	0	0	0	0	1	0	0	0	9997	884	31	1	1075	1	MTMR2	11	95582947	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	19210673	95582947	39423569	271	6563											
MTMR2	8898	broad.mit.edu	37	chr11	95583015	95583015	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcttgactttcaggatgaatCcatgataaaaccttaatgag	14	12	8	7	0	1	4	1	4	0	0	2	5	2	5	2	1	1	1	2	1	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:95583015C>G	uc001pfu.2	-	9	1069	c.816G>C	c.(814-816)TGG>TGC	p.W272C	MTMR2_uc001pfv.2_Missense_Mutation_p.W200C|MTMR2_uc001pfs.2_Missense_Mutation_p.W200C|MTMR2_uc001pft.2_Missense_Mutation_p.W200C|MTMR2_uc010ruj.1_Missense_Mutation_p.W255C	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	272	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAGGATGAATCCATGATAAAA	0.383													24	42					0	0	0	0	G	95583015	G	G	95583015	3	3	34	1	0	0	0	0	1	0	0	0	9997	856	30	2	1143	2	MTMR2	11	95583015	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	68	95583015	39423501	272	6564											
ARHGAP20	57569	broad.mit.edu	37	chr11	110450633	110450633	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtccttctttgtataggctgGgcggctgcaagcctgccctg	4	12	13	12	1	1	0	0	0	1	0	2	0	2	0	3	3	3	4	3	3	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:110450633G>T	uc001pkz.1	-	16	3322	c.3037C>A	c.(3037-3039)CCA>ACA	p.P1013T	ARHGAP20_uc001pky.1_Missense_Mutation_p.P990T|ARHGAP20_uc009yyb.1_Missense_Mutation_p.P977T|ARHGAP20_uc001pla.1_Missense_Mutation_p.P977T|ARHGAP20_uc001plb.2_Missense_Mutation_p.P556T	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1013					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GTATAGGCTGGGCGGCTGCAA	0.512													13	32					6.31663e-08	6.89342e-08	1	0	T	110450633	T	T	110450633	3	4	34	1	0	0	0	0	1	0	0	0	870	1232	43	4	542	4	ARHGAP20	11	110450633	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	14867618	110450633	24555883	273	6565											
KCNJ1	3758	broad.mit.edu	37	chr11	128709451	128709451	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcgtcaactacaaagttgaTattgatctggtccaaaataa	16	11	7	7	1	2	2	1	2	1	0	3	2	3	2	1	1	3	1	1	1	7	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:128709451T>C	uc001qeo.1	-	2	796	c.745A>G	c.(745-747)ATC>GTC	p.I249V	KCNJ1_uc001qep.1_Missense_Mutation_p.I230V|KCNJ1_uc001qeq.1_Missense_Mutation_p.I230V|KCNJ1_uc001qer.1_Missense_Mutation_p.I230V|KCNJ1_uc001qes.1_Missense_Mutation_p.I230V	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	249	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	ACAAAGTTGATATTGATCTGG	0.413													29	76					0	0	0	0	C	128709451	C	C	128709451	3	2	34	1	0	0	0	0	1	0	0	0	8082	1406	49	5	434	5	KCNJ1	11	128709451	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	18258818	128709451	6297065	274	6566											
ST14	6768	broad.mit.edu	37	chr11	130059706	130059706	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtggaggaggccgagcgCgtcatggccgaggagcgcgt	6	5	20	10	6	1	0	1	0	0	0	1	5	1	3	2	6	2	0	2	6	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:130059706C>T	uc001qfw.2	+	5	706	c.513C>T	c.(511-513)CGC>CGT	p.R171R	ST14_uc010sca.1_5'Flank	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	171	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	AGGCCGAGCGCGTCATGGCCG	0.677													24	102					0	0	0	0	T	130059706	T	T	130059706	2	4	34	1	0	0	0	0	0	0	0	1	15277	755	27	1		1	ST14	11	130059706	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1350255	130059706	4946810	275	6567											
GLB1L3	112937	broad.mit.edu	37	chr11	134163103	134163103	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatcagcttcataaagtccaGgtaagacatttcagacaggc	15	9	8	9	0	3	2	3	0	0	2	4	2	4	2	1	2	1	2	1	2	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr11:134163103G>A	uc009zdf.2	+	9	1236	c.876G>A	c.(874-876)CAG>CAA	p.Q292Q	GLB1L3_uc010scs.1_Silent_p.Q292Q|GLB1L3_uc010sct.1_Silent_p.Q144Q|GLB1L3_uc010scu.1_5'UTR	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	292					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		ATAAAGTCCAGGTAAGACATT	0.458													9	18					0	0	0	0	A	134163103	A	A	134163103	2	1	34	1	0	0	0	0	0	0	0	1	6467	1014	35	4		4	GLB1L3	11	134163103	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	4103397	134163103	843413	276	6568											
CACNA1C	775	broad.mit.edu	37	chr12	2614034	2614034	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatgccgtaggaagggactgGccctggatctattttgttac	8	12	13	8	1	1	0	0	0	1	0	1	4	1	3	2	4	2	2	2	4	4	5	rs1051347		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:2614034G>A	uc009zdu.1	+	8	1453	c.1140G>A	c.(1138-1140)TGG>TGA	p.W380*	CACNA1C_uc009zdv.1_Nonsense_Mutation_p.W377*|CACNA1C_uc001qkb.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkc.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qke.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkf.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qjz.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkd.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkg.2_Nonsense_Mutation_p.W380*|CACNA1C_uc009zdw.1_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkh.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkl.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkn.2_Intron|CACNA1C_uc001qko.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkp.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkr.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qku.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkq.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qks.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qkt.2_Nonsense_Mutation_p.W380*|CACNA1C_uc001qka.1_Intron|CACNA1C_uc001qki.1_Intron|CACNA1C_uc001qkj.1_Intron|CACNA1C_uc001qkk.1_Intron|CACNA1C_uc001qkm.1_Intron|CACNA1C_uc009zdy.1_Intron|CACNA1C_uc001qkv.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	380	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GAAGGGACTGGCCCTGGATCT	0.512													9	22					0	0	0	0	A	2614034	A	A	2614034	4	1	34	1	0	0	0	0	0	1	0	0	2552	1212	42	4	1278	4	CACNA1C	12	2614034	Nonsense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08		2614034	131237861	277	6569											
C12orf4	57102	broad.mit.edu	37	chr12	4634429	4634429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atagttaatacctaagggagCtgttgttggggttttttagg	9	16	13	3	0	0	0	0	0	0	0	0	1	0	1	1	4	2	5	1	4	5	9			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:4634429C>T	uc001qms.2	-	6	807	c.719G>A	c.(718-720)AGC>AAC	p.S240N	C12orf4_uc001qmt.2_Missense_Mutation_p.S240N	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	240											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CCTAAGGGAGCTGTTGTTGGG	0.313													25	92					0	0	0	0	T	4634429	T	T	4634429	3	4	34	1	0	0	0	0	1	0	0	0	1691	797	28	4	975	4	C12orf4	12	4634429	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2020395	4634429	129217466	278	6570											
PLEKHG6	55200	broad.mit.edu	37	chr12	6422904	6422904	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagagcccgagaagaggcAcgggggccatgtgggggctg	8	4	19	10	2	0	3	0	0	0	3	1	4	1	3	3	5	1	2	3	5	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:6422904A>C	uc001qnr.2	+	3	396	c.248A>C	c.(247-249)CAC>CCC	p.H83P	PLEKHG6_uc001qns.2_Missense_Mutation_p.H83P|PLEKHG6_uc010sew.1_Missense_Mutation_p.H83P|PLEKHG6_uc010sex.1_Missense_Mutation_p.H51P	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	83					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						GAGAAGAGGCACGGGGGCCAT	0.647													18	81					0	0	0	0	C	6422904	C	C	6422904	3	2	34	1	0	0	0	0	1	0	0	0	12129	159	6	5	300	5	PLEKHG6	12	6422904	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	1788475	6422904	127428991	279	6571											
CSDA	8531	broad.mit.edu	37	chr12	10862544	10862544	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtaagacccgtgagcgaCggtcaaaggtctgtcccacg	9	6	15	11	4	2	2	1	1	1	1	3	3	3	2	2	4	1	1	2	4	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:10862544C>G	uc001qyt.2	-	6	986	c.743G>C	c.(742-744)CGT>CCT	p.R248P	CSDA_uc001qyu.2_Intron	NM_003651	NP_003642	P16989	DBPA_HUMAN	cold shock domain protein A isoform a	248					negative regulation of transcription from RNA polymerase II promoter|response to cold	cytoplasm|nucleus	double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|lung(1)|large_intestine(1)	4	Glioma(1;0.155)					CCGTGAGCGACGGTCAAAGGT	0.542													18	56					0	0	0	0	G	10862544	G	G	10862544	3	3	34	1	0	0	0	0	1	0	0	0	3944	536	19	3	391	3	CSDA	12	10862544	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	4439640	10862544	122989351	280	6572											
PIK3C2G	5288	broad.mit.edu	37	chr12	18499618	18499618	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaactatccacatccatctaCcagctaatcaatgtctactg	13	11	4	13	0	3	0	1	0	2	0	5	1	5	0	3	0	4	1	3	0	6	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:18499618C>A	uc001rdt.2	+	11	1589	c.1473C>A	c.(1471-1473)TAC>TAA	p.Y491*	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Nonsense_Mutation_p.Y491*|PIK3C2G_uc010sic.1_Nonsense_Mutation_p.Y269*	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	491					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				CATCCATCTACCAGCTAATCA	0.418													36	108					2.24893e-16	2.78982e-16	1	0	A	18499618	A	A	18499618	4	1	34	1	0	0	0	0	0	1	0	0	11966	518	18	4	1511	4	PIK3C2G	12	18499618	Nonsense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	7637074	18499618	115352277	281	6573											
ITPR2	3709	broad.mit.edu	37	chr12	26647123	26647123	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctccttcaagcaaggcaatgCcgaggaaaatgccttctgaa	13	8	9	11	1	2	1	1	1	1	0	3	3	3	2	3	2	3	2	3	2	6	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:26647123C>A	uc001rhg.2	-	39	5750	c.5333G>T	c.(5332-5334)GGC>GTC	p.G1778V	ITPR2_uc009zjg.1_5'UTR	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1778	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					CAAGGCAATGCCGAGGAAAAT	0.373													19	55					1.50039e-11	1.73394e-11	1	0	A	26647123	A	A	26647123	3	1	34	1	0	0	0	0	1	0	0	0	7960	739	26	4	2848	4	ITPR2	12	26647123	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	8147505	26647123	107204772	282	6574											
KIF21A	55605	broad.mit.edu	37	chr12	39695465	39695465	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcacagacccaatccttaTgtgcatttggaacttgctaa	11	11	9	10	0	0	1	0	0	0	1	1	2	1	2	2	2	3	3	2	2	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:39695465T>A	uc001rly.2	-	37	4894	c.4748A>T	c.(4747-4749)CAT>CTT	p.H1583L	KIF21A_uc001rlv.2_Missense_Mutation_p.H528L|KIF21A_uc001rlw.2_Missense_Mutation_p.H853L|KIF21A_uc001rlx.2_Missense_Mutation_p.H1570L|KIF21A_uc001rlz.2_Missense_Mutation_p.H1530L|KIF21A_uc010skl.1_Missense_Mutation_p.H1546L|KIF21A_uc001rlt.2_Missense_Mutation_p.H203L|KIF21A_uc001rlu.2_Missense_Mutation_p.H203L	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1583	WD 6.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CCAATCCTTATGTGCATTTGG	0.418													74	221					0	0	0	0	A	39695465	A	A	39695465	3	1	34	1	0	0	0	0	1	0	0	0	8327	1464	51	5	284	5	KIF21A	12	39695465	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	13048342	39695465	94156430	283	6575											
LRRK2	120892	broad.mit.edu	37	chr12	40749922	40749922	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttttccttttagcaaacAaaaaaattttcttttggttg	12	19	4	6	0	1	0	0	0	1	0	2	0	2	0	1	1	2	2	1	1	5	9			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:40749922A>G	uc001rmg.3	+	46	6897	c.6776A>G	c.(6775-6777)CAA>CGA	p.Q2259R	LRRK2_uc009zjw.2_Missense_Mutation_p.Q1097R|LRRK2_uc001rmi.2_Missense_Mutation_p.Q1092R	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2259					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTTAGCAAACAAAAAAATTTT	0.214													4	11					0	0	0	0	G	40749922	G	G	40749922	3	3	34	1	0	0	0	0	1	0	0	0	9083	130	5	5	6958	5	LRRK2	12	40749922	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	1054457	40749922	93101973	284	6576											
SRGAP1	57522	broad.mit.edu	37	chr12	64521798	64521798	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggggcctgctgcagaacCgtggcctcaacaatgacagt	9	6	12	14	2	1	2	1	1	0	1	1	2	1	2	4	3	4	2	4	3	3	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:64521798C>A	uc010ssp.1	+	21	2754	c.2698C>A	c.(2698-2700)CGT>AGT	p.R900S	SRGAP1_uc001srv.2_Missense_Mutation_p.R837S	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	900					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		GCTGCAGAACCGTGGCCTCAA	0.632													15	47					4.14922e-12	4.82926e-12	1	0	A	64521798	A	A	64521798	3	1	34	1	0	0	0	0	1	0	0	0	15211	652	23	3	2780	3	SRGAP1	12	64521798	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	23771876	64521798	69330097	285	6577											
TRHDE	29953	broad.mit.edu	37	chr12	72956773	72956773	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attacccaacagcattttatCtatgatatcagtgctaaaac	15	13	4	9	0	2	1	1	1	1	0	2	1	2	1	1	0	5	2	1	0	7	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:72956773C>G	uc001sxa.2	+	9	1890	c.1860C>G	c.(1858-1860)ATC>ATG	p.I620M		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	620	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						AGCATTTTATCTATGATATCA	0.318													29	76					0	0	0	0	G	72956773	G	G	72956773	3	3	34	1	0	0	0	0	1	0	0	0	16546	903	32	2	1894	2	TRHDE	12	72956773	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	8434975	72956773	60895122	286	6578											
LIN7A	8825	broad.mit.edu	37	chr12	81205380	81205380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tttcttccagaacttttgggGtgtatcgcaccaccagcttg	7	14	9	11	1	1	1	0	0	1	1	3	1	2	1	3	2	2	3	3	2	2	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:81205380G>A	uc001szj.1	-	5	759	c.566C>T	c.(565-567)ACC>ATC	p.T189I	LIN7A_uc001szk.1_RNA	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	189	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						AACTTTTGGGGTGTATCGCAC	0.443													12	43					0	0	0	0	A	81205380	A	A	81205380	3	1	34	1	0	0	0	0	1	0	0	0	8852	1261	44	4	139	4	LIN7A	12	81205380	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	8248607	81205380	52646515	287	6579											
CCDC41	51134	broad.mit.edu	37	chr12	94725487	94725487	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacttgcctttttctgggCaattgcagctcgctgcagtt	6	14	9	12	1	1	0	0	0	1	0	2	0	1	0	2	1	4	6	2	1	1	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:94725487C>T	uc001tdd.2	-	14	2282	c.1696G>A	c.(1696-1698)GCC>ACC	p.A566T	CCDC41_uc001tde.2_Missense_Mutation_p.A566T|CCDC41_uc009zsw.1_RNA	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	558	Potential.										0						TTTTTCTGGGCAATTGCAGCT	0.289													39	151					0	0	0	0	T	94725487	T	T	94725487	3	4	34	1	0	0	0	0	1	0	0	0	2826	710	25	4	425	4	CCDC41	12	94725487	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	13520107	94725487	39126408	288	6580											
VEZT	55591	broad.mit.edu	37	chr12	95660293	95660293	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aactacaagtgaccctaaaaAaatacagcgttcatttggaa	18	9	6	8	1	1	1	1	1	0	0	1	2	1	2	1	1	4	1	1	1	9	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:95660293A>G	uc001tdz.2	+	5	700	c.595A>G	c.(595-597)AAA>GAA	p.K199E	VEZT_uc009zsy.1_Missense_Mutation_p.K41E|VEZT_uc001tdr.2_Missense_Mutation_p.K41E|VEZT_uc001tds.2_Missense_Mutation_p.K151E|VEZT_uc001tdt.2_Missense_Mutation_p.K151E|VEZT_uc009zsz.1_Missense_Mutation_p.K199E|VEZT_uc001tdv.2_Missense_Mutation_p.K168E|VEZT_uc001tdw.1_Missense_Mutation_p.K151E|VEZT_uc009zta.1_Missense_Mutation_p.K151E	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	199						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						GACCCTAAAAAAATACAGCGT	0.418													30	99					0	0	0	0	G	95660293	G	G	95660293	3	3	34	1	0	0	0	0	1	0	0	0	17224	15	1	5	613	5	VEZT	12	95660293	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	934806	95660293	38191602	289	6581											
AMDHD1	144193	broad.mit.edu	37	chr12	96360158	96360158	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catctggcctgtgtaaacatGagaatgtccatgcctgaggc	10	10	11	10	0	1	2	0	2	1	1	2	3	2	2	3	2	2	1	3	2	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:96360158G>A	uc001tel.1	+	8	1171	c.1065G>A	c.(1063-1065)ATG>ATA	p.M355I	AMDHD1_uc009zth.1_Missense_Mutation_p.M246I	NM_152435	NP_689648	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	355					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)	1						GTGTAAACATGAGAATGTCCA	0.478													20	63					0	0	0	0	A	96360158	A	A	96360158	3	1	34	1	0	0	0	0	1	0	0	0	567	1290	45	2	1095	2	AMDHD1	12	96360158	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	699865	96360158	37491737	290	6582											
APPL2	55198	broad.mit.edu	37	chr12	105569861	105569861	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaattaatagcataacatatCtgcaaaagacaagaaaagta	23	8	5	5	0	1	2	0	0	1	2	1	2	1	2	0	0	3	3	0	0	11	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:105569861C>T	uc001tlf.1	-	20	2031	c.1813_splice	c.e20-1	p.I605_splice	APPL2_uc010swt.1_Splice_Site_p.I562_splice|APPL2_uc001tlg.1_Splice_Site_p.I359_splice|APPL2_uc010swu.1_Splice_Site_p.I611_splice	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH						cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CATAACATATCTGCAAAAGAC	0.353													12	39					0	0	0	0	T	105569861	T	T	105569861	5	4	34	1	0	0	0	0	0	0	1	0	818	927	32	2	190	2	APPL2	12	105569861	Splice_Site	SNP	C	TCGA-BB-7871-01A-11D-2229-08	9209703	105569861	28282034	291	6583											
ACACB	32	broad.mit.edu	37	chr12	109609642	109609642	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcggatcattacgtccccGtcccaggagggcccaataac	9	7	11	14	3	1	0	1	0	0	0	3	2	3	2	4	4	2	0	4	4	3	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:109609642G>T	uc001tob.2	+	5	1077	c.958G>T	c.(958-960)GTC>TTC	p.V320F	ACACB_uc001toc.2_Missense_Mutation_p.V320F	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	320	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TTACGTCCCCGTCCCAGGAGG	0.502													11	51					0.00010058	0.000105083	1	0	T	109609642	T	T	109609642	3	4	34	1	0	0	0	0	1	0	0	0	107	1145	40	3	972	3	ACACB	12	109609642	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	4039781	109609642	24242253	292	6584											
GLTP	51228	broad.mit.edu	37	chr12	110290415	110290415	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtacatctcgtagatgacaTcgatggtcgccgtgtagttg	8	13	12	8	4	1	2	0	1	1	1	4	3	1	2	1	1	1	4	1	1	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:110290415T>C	uc001tpm.2	-	5	689	c.575A>G	c.(574-576)GAT>GGT	p.D192G	GLTP_uc010sxt.1_RNA	NM_016433	NP_057517	Q9NZD2	GLTP_HUMAN	glycolipid transfer protein	192						cytoplasm	glycolipid binding|glycolipid transporter activity				0		Lung NSC(355;2.38e-06)|Breast(359;0.00354)|Myeloproliferative disorder(1001;0.0122)		BRCA - Breast invasive adenocarcinoma(302;0.0025)		GTAGATGACATCGATGGTCGC	0.552											OREG0022112	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	107	391					0	0	0	0	C	110290415	C	C	110290415	3	2	34	1	0	0	0	0	1	0	0	0	6508	1435	50	5	58	5	GLTP	12	110290415	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	680773	110290415	23561480	293	6585											
TBX3	6926	broad.mit.edu	37	chr12	115112304	115112304	+	Frame_Shift_Del	DEL	A	-	-																															tctgcaccgtgagcggcgcgAaggcctccttgcccgggagc																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:115112304delA	uc001tvt.1	-	7	2400	c.1436delT	c.(1435-1437)TTCfs	p.F479fs	TBX3_uc001tvu.1_Frame_Shift_Del_p.F459fs	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	479					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		GAGCGGCGCGAAGGCCTCCTT	0.781													---	---	---								-	115112304	-	-	115112304	7	5	34	1	0	1	0	1	0	0	0	0	15725	246	9	0	803	0	TBX3	12	115112304	Frame_Shift_Del	DEL	A	TCGA-BB-7871-01A-11D-2229-08	4821889	115112304	18739591	294	6586											
CLIP1	6249	broad.mit.edu	37	chr12	122794336	122794336	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgacttgtgacttcgtccctGcttctccccagctcctcagc	4	13	7	17	1	2	2	1	2	1	0	6	2	4	2	4	0	3	2	4	0	0	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:122794336G>T	uc001ucg.1	-	19	3673	c.3567C>A	c.(3565-3567)AGC>AGA	p.S1189R	CLIP1_uc001uch.1_Missense_Mutation_p.S1178R|CLIP1_uc001uci.1_Missense_Mutation_p.S1143R|CLIP1_uc001ucj.1_Missense_Mutation_p.S764R	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1189	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTTCGTCCCTGCTTCTCCCCA	0.552													14	61					2.48551e-13	2.94178e-13	1	0	T	122794336	T	T	122794336	3	4	34	1	0	0	0	0	1	0	0	0	3547	1310	46	4	777	4	CLIP1	12	122794336	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	7682032	122794336	11057559	295	6587											
P2RX2	22953	broad.mit.edu	37	chr12	133197632	133197632	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgggactgtgacctggacCtgcctgcatcggagtgcaac	8	8	13	12	1	0	1	0	1	0	0	1	4	0	4	3	3	4	2	3	3	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr12:133197632C>A	uc001ukj.1	+	8	820	c.820C>A	c.(820-822)CTG>ATG	p.L274M	P2RX2_uc001uki.1_Missense_Mutation_p.L274M|P2RX2_uc001ukk.1_Missense_Mutation_p.L274M|P2RX2_uc001ukl.1_Missense_Mutation_p.L250M|P2RX2_uc001ukm.1_Missense_Mutation_p.L202M|P2RX2_uc001ukn.1_Missense_Mutation_p.L182M|P2RX2_uc009zyt.1_Missense_Mutation_p.L274M|P2RX2_uc001uko.1_Missense_Mutation_p.L240M	NM_170682	NP_733782	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X2 isoform A	274	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		TGACCTGGACCTGCCTGCATC	0.602													27	84					1.16021e-09	1.30092e-09	1	0	A	133197632	A	A	133197632	3	1	34	1	0	0	0	0	1	0	0	0	11394	680	24	4	850	4	P2RX2	12	133197632	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	10403296	133197632	654263	296	6588											
DCLK1	9201	broad.mit.edu	37	chr13	36410270	36410270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggaatctggaagccttcctCcgacacttctgaaagaatca	12	10	8	11	1	3	2	1	1	2	1	5	5	5	4	3	2	1	0	3	2	4	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr13:36410270C>T	uc001uvf.2	-	8	1362	c.1129G>A	c.(1129-1131)GAG>AAG	p.E377K	DCLK1_uc001uve.3_Missense_Mutation_p.E70K|DCLK1_uc010teh.1_Missense_Mutation_p.E70K|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	377					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		AAGCCTTCCTCCGACACTTCT	0.358													27	90					0	0	0	0	T	36410270	T	T	36410270	3	4	34	1	0	0	0	0	1	0	0	0	4308	864	30	2	1104	2	DCLK1	13	36410270	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08		36410270	78759608	297	6589											
POSTN	10631	broad.mit.edu	37	chr13	38151925	38151925	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggatttctttgaaggtgctaCcacgaacaaactgaaaataa	16	10	8	7	1	1	2	0	2	1	0	1	4	1	3	1	2	4	1	1	2	7	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr13:38151925C>A	uc001uwo.3	-	16	2091	c.1973G>T	c.(1972-1974)GGT>GTT	p.G658V	POSTN_uc010tet.1_Missense_Mutation_p.G186V|POSTN_uc001uwp.3_Missense_Mutation_p.G658V|POSTN_uc001uwr.2_Missense_Mutation_p.G658V|POSTN_uc001uwq.2_Missense_Mutation_p.G658V|POSTN_uc010teu.1_Missense_Mutation_p.G658V|POSTN_uc010tev.1_Missense_Mutation_p.G658V|POSTN_uc010tew.1_Missense_Mutation_p.G658V	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	658					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GAAGGTGCTACCACGAACAAA	0.318													11	19					6.49762e-13	7.63509e-13	1	0	A	38151925	A	A	38151925	3	1	34	1	0	0	0	0	1	0	0	0	12314	507	18	4	569	4	POSTN	13	38151925	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1741655	38151925	77017953	298	6590											
TRPC4	7223	broad.mit.edu	37	chr13	38211293	38211293	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggaatgctcaggtcacccCgtgaagctaatcctcgagat	10	8	11	12	3	2	2	2	1	0	1	4	4	3	3	3	2	2	2	3	2	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr13:38211293C>A	uc001uws.2	-	11	2916	c.2681G>T	c.(2680-2682)CGG>CTG	p.R894L	TRPC4_uc010abv.2_Missense_Mutation_p.R474L|TRPC4_uc001uwt.2_Missense_Mutation_p.R810L|TRPC4_uc010tey.1_Missense_Mutation_p.R753L|TRPC4_uc010abw.2_Missense_Mutation_p.R721L|TRPC4_uc010abx.2_Missense_Mutation_p.R899L|TRPC4_uc010aby.2_Missense_Mutation_p.R745L	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	894	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CAGGTCACCCCGTGAAGCTAA	0.468													18	47					3.32936e-07	3.58546e-07	1	0	A	38211293	A	A	38211293	3	1	34	1	0	0	0	0	1	0	0	0	16647	652	23	3	256	3	TRPC4	13	38211293	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	59368	38211293	76958585	299	6591											
LMO7	4008	broad.mit.edu	37	chr13	76414620	76414620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggcagaaggagcaggacCgcctactgcaggtagctctg	9	6	16	10	1	1	1	0	0	1	1	1	3	1	3	2	5	4	5	2	5	3	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr13:76414620C>T	uc001vjv.2	+	19	3632	c.2872C>T	c.(2872-2874)CGC>TGC	p.R958C	LMO7_uc010thv.1_Missense_Mutation_p.R909C|LMO7_uc001vjt.1_Missense_Mutation_p.R857C|LMO7_uc010thw.1_Missense_Mutation_p.R835C|LMO7_uc001vjw.1_Missense_Mutation_p.R864C	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1243						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GGAGCAGGACCGCCTACTGCA	0.542													7	27					0	0	0	0	T	76414620	T	T	76414620	3	4	34	1	0	0	0	0	1	0	0	0	8897	652	23	1	3817	1	LMO7	13	76414620	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	38203327	76414620	38755258	300	6592											
MYO16	23026	broad.mit.edu	37	chr13	109792671	109792671	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgaagaagattcctcctCgaaagcccaagcgcagcccc	12	5	8	16	2	0	3	0	1	0	2	3	4	2	3	6	0	3	1	6	0	4	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr13:109792671C>A	uc001vqt.1	+	32	4171	c.4045C>A	c.(4045-4047)CGA>AGA	p.R1349R	MYO16_uc010agk.1_Silent_p.R1371R	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1349					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GATTCCTCCTCGAAAGCCCAA	0.512													14	23					2.35188e-11	2.69888e-11	1	0	A	109792671	A	A	109792671	2	1	34	1	0	0	0	0	0	0	0	1	10117	876	31	3		3	MYO16	13	109792671	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	33378051	109792671	5377207	301	6593											
MIA2	117153	broad.mit.edu	37	chr14	39721980	39721980	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctaacatagagttacctacGagaattcacgaagaagtata	17	10	7	7	2	2	3	1	0	1	3	2	5	2	3	1	0	3	2	1	0	9	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr14:39721980G>A	uc001wux.2	+	5	1790	c.1596G>A	c.(1594-1596)ACG>ACA	p.T532T		NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	Error:Variant_position_missing_in_Q96PC5_after_alignment						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		AGTTACCTACGAGAATTCACG	0.368													19	48					0	0	0	0	A	39721980	A	A	39721980	2	1	34	1	0	0	0	0	0	0	0	1	9617	1045	37	1		1	MIA2	14	39721980	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08		39721980	67627560	302	6594											
LRFN5	145581	broad.mit.edu	37	chr14	42356278	42356278	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgatgtcttcgcccttgaGgagctggatctgtcctataa	8	13	11	9	1	2	2	0	2	2	0	4	5	3	4	2	2	1	1	2	2	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr14:42356278G>T	uc001wvm.2	+	3	1648	c.450G>T	c.(448-450)GAG>GAT	p.E150D	LRFN5_uc010ana.2_Missense_Mutation_p.E150D	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	150	Extracellular (Potential).|LRR 5.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TCGCCCTTGAGGAGCTGGATC	0.393										HNSCC(30;0.082)			21	49					1.28384e-07	1.39486e-07	1	0	T	42356278	T	T	42356278	3	4	34	1	0	0	0	0	1	0	0	0	8991	991	35	4	452	4	LRFN5	14	42356278	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2634298	42356278	64993262	303	6595											
LRFN5	145581	broad.mit.edu	37	chr14	42356945	42356945	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacacaaatagtggatcttCatataattaagctccctcac	15	11	4	11	0	3	0	2	0	1	0	4	1	4	1	1	1	2	1	1	1	6	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr14:42356945C>G	uc001wvm.2	+	3	2315	c.1117C>G	c.(1117-1119)CAT>GAT	p.H373D	LRFN5_uc010ana.2_Missense_Mutation_p.H373D	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	373	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AGTGGATCTTCATATAATTAA	0.403										HNSCC(30;0.082)			19	50					0	0	0	0	G	42356945	G	G	42356945	3	3	34	1	0	0	0	0	1	0	0	0	8991	826	29	2	1119	2	LRFN5	14	42356945	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	667	42356945	64992595	304	6596											
POLE2	5427	broad.mit.edu	37	chr14	50136312	50136312	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	taaataattcatgcctgtggGtcctctataaaaaagaaaga	17	11	7	6	0	2	2	1	0	1	2	3	2	3	2	2	1	1	0	2	1	8	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr14:50136312G>T	uc001wwu.2	-	6	436	c.422C>A	c.(421-423)ACC>AAC	p.T141N	SDCCAG1_uc010anj.1_Intron|POLE2_uc001wwv.2_RNA	NM_002692	NP_002683	P56282	DPOE2_HUMAN	DNA-directed DNA polymerase epsilon 2	141					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			ovary(1)|skin(1)	2	all_epithelial(31;0.0021)|Breast(41;0.0124)					ATGCCTGTGGGTCCTCTATAA	0.373													13	42					0.000219431	0.0002278	1	0	T	50136312	T	T	50136312	3	4	34	1	0	0	0	0	1	0	0	0	12252	1261	44	4	1217	4	POLE2	14	50136312	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	7779367	50136312	57213228	305	6597											
GPR65	8477	broad.mit.edu	37	chr14	88477767	88477767	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaggacgtgtacaggctaTgcaatacctttggtcaccat	10	12	9	10	1	2	0	2	0	0	0	2	1	2	1	2	3	3	3	2	3	4	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr14:88477767T>C	uc001xvv.2	+	2	1106	c.576T>C	c.(574-576)TAT>TAC	p.Y192Y		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	192	Helical; Name=5; (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						GTACAGGCTATGCAATACCTT	0.413													20	58					0	0	0	0	C	88477767	C	C	88477767	2	2	34	1	0	0	0	0	0	0	0	1	6744	1471	51	5		5	GPR65	14	88477767	Silent	SNP	T	TCGA-BB-7871-01A-11D-2229-08	38341455	88477767	18871773	306	6598											
BDKRB1	623	broad.mit.edu	37	chr14	96730747	96730747	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggacaaggtgcgggggccGcaaggatagcaagaccacag	13	2	16	10	2	0	1	0	0	0	1	0	3	0	3	2	5	2	2	2	5	4	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr14:96730747G>T	uc001yfh.2	+	3	936	c.728G>T	c.(727-729)CGC>CTC	p.R243L	BDKRB1_uc010avn.2_Intron	NM_000710	NP_000701	P46663	BKRB1_HUMAN	bradykinin receptor B1	243	Cytoplasmic (Potential).			CGGR -> VRGP (in Ref. 1, 2 and 3).	elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			ovary(3)	3		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		TGCGGGGGCCGCAAGGATAGC	0.587													19	57					2.35188e-11	2.69888e-11	1	0	T	96730747	T	T	96730747	3	4	34	1	0	0	0	0	1	0	0	0	1394	1087	38	3	730	3	BDKRB1	14	96730747	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	8252980	96730747	10618793	307	6599											
MAGEL2	54551	broad.mit.edu	37	chr15	23889873	23889873	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaccttggaattatcctggGtggcactggatcccggagag	8	9	13	11	1	0	1	0	0	0	1	2	4	2	3	4	5	0	1	4	5	2	2	rs138628273	by1000genomes	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr15:23889873G>C	uc001ywj.3	-	1	1303	c.1208C>G	c.(1207-1209)ACC>AGC	p.T403S		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		ATTATCCTGGGTGGCACTGGA	0.587													6	25					0	0	0	0	C	23889873	C	C	23889873	3	2	34	1	0	0	0	0	1	0	0	0	9242	1261	44	4	736	4	MAGEL2	15	23889873	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08		23889873	78641519	308	6600											
B2M	567	broad.mit.edu	37	chr15	45007752	45007752	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagaatggagagagaattGaaaaagtggagcattcagac	18	7	13	3	0	1	6	1	2	0	4	1	9	1	7	0	2	1	1	0	2	5	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr15:45007752G>T	uc001zuc.2	+	2	259	c.199G>T	c.(199-201)GAA>TAA	p.E67*	B2M_uc010uek.1_Nonsense_Mutation_p.E67*|B2M_uc010bdx.1_Nonsense_Mutation_p.E67*	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	67	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		AGAGAGAATTGAAAAAGTGGA	0.413													48	81					8.00217e-19	1.00799e-18	1	0	T	45007752	T	T	45007752	4	4	34	1	0	0	0	0	0	1	0	0	1246	1291	45	2	205	2	B2M	15	45007752	Nonsense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	21117879	45007752	57523640	309	6601											
UNC13C	440279	broad.mit.edu	37	chr15	54305604	54305604	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctctgagggcagctctgaCggggagcgtactctacatgg	7	8	14	12	2	3	2	0	2	3	0	3	3	3	3	1	4	4	3	1	4	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr15:54305604C>T	uc002ack.2	+	1	504	c.504C>T	c.(502-504)GAC>GAT	p.D168D		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	168					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCAGCTCTGACGGGGAGCGTA	0.473													25	61					0	0	0	0	T	54305604	T	T	54305604	2	4	34	1	0	0	0	0	0	0	0	1	17054	535	19	1		1	UNC13C	15	54305604	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	9297852	54305604	48225788	310	6602											
TLN2	83660	broad.mit.edu	37	chr15	63092597	63092597	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaatgccatcaaagatgtgGccaaggccctttctgatctc	10	11	8	12	0	4	2	2	1	2	1	5	2	4	2	3	2	1	0	3	2	3	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr15:63092597G>T	uc002alb.3	+	46	6265	c.6265G>T	c.(6265-6267)GCC>TCC	p.A2089S	TLN2_uc002alc.3_Missense_Mutation_p.A482S	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	2089					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CAAAGATGTGGCCAAGGCCCT	0.537													35	127					2.0683e-36	2.89561e-36	1	0	T	63092597	T	T	63092597	3	4	34	1	0	0	0	0	1	0	0	0	16014	1203	42	4	6447	4	TLN2	15	63092597	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	8786993	63092597	39438795	311	6603											
SLC24A1	9187	broad.mit.edu	37	chr15	65917057	65917057	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaatggaaacaagccatgcGatcacccccaggacaacagt	16	4	8	13	1	1	0	1	0	0	0	1	3	1	2	3	2	4	0	3	2	4	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr15:65917057G>A	uc010ujf.1	+	2	926	c.639G>A	c.(637-639)GCG>GCA	p.A213A	SLC24A1_uc010ujd.1_Silent_p.A213A|SLC24A1_uc010uje.1_Silent_p.A213A|SLC24A1_uc010ujg.1_Silent_p.A213A|SLC24A1_uc010ujh.1_Silent_p.A213A	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	213	Extracellular (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						CAAGCCATGCGATCACCCCCA	0.458													8	11					0	0	0	0	A	65917057	A	A	65917057	2	1	34	1	0	0	0	0	0	0	0	1	14529	1045	37	1		1	SLC24A1	15	65917057	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2824460	65917057	36614335	312	6604											
ARNT2	9915	broad.mit.edu	37	chr15	80872831	80872831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacatgtcccaaatctccCggcagctaaaccagagtcag	14	6	8	13	1	2	2	1	0	1	2	4	2	3	2	3	1	3	2	3	1	4	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr15:80872831C>T	uc002bfr.2	+	16	1859	c.1693C>T	c.(1693-1695)CGG>TGG	p.R565W	ARNT2_uc010unm.1_Missense_Mutation_p.R554W|ARNT2_uc002bfs.2_Missense_Mutation_p.R554W	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	565					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			CCAAATCTCCCGGCAGCTAAA	0.542													16	61					0	0	0	0	T	80872831	T	T	80872831	3	4	34	1	0	0	0	0	1	0	0	0	968	643	23	1	1755	1	ARNT2	15	80872831	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	14955774	80872831	21658561	313	6605											
SH3GL3	6457	broad.mit.edu	37	chr15	84245351	84245351	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagcatcacctgaaaaagcTggaaggccgccgcctggatt	11	8	11	11	2	1	1	1	1	0	0	1	3	1	3	4	3	2	2	4	3	4	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr15:84245351T>A	uc002bjw.2	+	6	677	c.482T>A	c.(481-483)CTG>CAG	p.L161Q	SH3GL3_uc010uot.1_Missense_Mutation_p.L161Q|SH3GL3_uc002bjx.2_Missense_Mutation_p.L92Q|SH3GL3_uc002bju.2_Missense_Mutation_p.L169Q|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	161	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						CTGAAAAAGCTGGAAGGCCGC	0.393													7	23					0	0	0	0	A	84245351	A	A	84245351	3	1	34	1	0	0	0	0	1	0	0	0	14317	1580	55	5	504	5	SH3GL3	15	84245351	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	3372520	84245351	18286041	314	6606											
AKAP13	11214	broad.mit.edu	37	chr15	86283466	86283466	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggcagcaggttgtccagaGcgttgttcatctctacgagc	7	12	12	10	2	2	1	1	0	1	1	4	2	3	1	1	2	4	5	1	2	1	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr15:86283466G>A	uc002blv.1	+	34	7741	c.7571G>A	c.(7570-7572)AGC>AAC	p.S2524N	AKAP13_uc002blu.1_Missense_Mutation_p.S2528N|AKAP13_uc002blw.1_Missense_Mutation_p.S989N|AKAP13_uc002blx.1_Missense_Mutation_p.S769N	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2524	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GTTGTCCAGAGCGTTGTTCAT	0.473													20	45					0	0	0	0	A	86283466	A	A	86283466	3	1	34	1	0	0	0	0	1	0	0	0	449	971	34	4	7771	4	AKAP13	15	86283466	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2038115	86283466	16247926	315	6607											
IQGAP1	8826	broad.mit.edu	37	chr15	91021068	91021068	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacatcaaaactgaccctgtGgatatttacaaatcttgggt	14	12	7	8	0	2	1	1	1	1	0	2	2	2	2	1	2	3	0	1	2	6	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr15:91021068G>T	uc002bpl.1	+	26	3377	c.3276G>T	c.(3274-3276)GTG>GTT	p.V1092V		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1092	Ras-GAP.|C1.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CTGACCCTGTGGATATTTACA	0.433													22	92					9.39395e-14	1.11996e-13	1	0	T	91021068	T	T	91021068	2	4	34	1	0	0	0	0	0	0	0	1	7853	1335	47	4		4	IQGAP1	15	91021068	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	4737602	91021068	11510324	316	6608											
LASS3	204219	broad.mit.edu	37	chr15	101042026	101042026	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagccagaatctttccaacCagaaccattctttaaacgtc	14	10	5	12	1	2	2	0	0	2	2	4	3	3	2	4	0	4	0	4	0	6	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr15:101042026C>A	uc002bvz.2	-	4	531	c.29G>T	c.(28-30)TGG>TTG	p.W10L	LASS3_uc002bwa.2_Missense_Mutation_p.W21L|LASS3_uc002bwb.2_Missense_Mutation_p.W10L	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	10						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			TCTTTCCAACCAGAACCATTC	0.373													13	53					0.000566183	0.000582836	1	0	A	101042026	A	A	101042026	3	1	34	1	0	0	0	0	1	0	0	0	8680	595	21	4	1162	4	LASS3	15	101042026	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	10020958	101042026	1489366	317	6609											
C16orf42	115939	broad.mit.edu	37	chr16	1400112	1400112	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccaagaactcctgctccGcctgcagcacctcctccggg	6	7	10	18	2	0	1	0	0	0	1	4	1	4	1	7	2	4	3	7	2	2	0	rs142109530	byFrequency	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:1400112G>A	uc002cll.2	-	4	718	c.650C>T	c.(649-651)GCG>GTG	p.A217V	GNPTG_uc002clm.2_5'Flank	NM_001001410	NP_001001410	Q9UJK0	TSR3_HUMAN	hypothetical protein LOC115939	217					rRNA processing						0		Hepatocellular(780;0.0893)				CTCCTGCTCCGCCTGCAGCAC	0.647													4	13					0	0	0	0	A	1400112	A	A	1400112	3	1	34	1	0	0	0	0	1	0	0	0	1819	1087	38	1	300	1	C16orf42	16	1400112	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08		1400112	88954641	318	6610											
HS3ST6	64711	broad.mit.edu	37	chr16	1961835	1961835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccaggaagtcctgcacgCggccgacctctccggccggg	5	4	15	17	5	1	0	0	0	1	0	3	2	2	1	6	5	1	1	6	5	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:1961835C>T	uc002cnf.2	-	2	692	c.692G>A	c.(691-693)CGC>CAC	p.R231H		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	231											0						GTCCTGCACGCGGCCGACCTC	0.667													35	95					0	0	0	0	T	1961835	T	T	1961835	3	4	34	1	0	0	0	0	1	0	0	0	7408	768	27	1	247	1	HS3ST6	16	1961835	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	561723	1961835	88392918	319	6611											
TBL3	10607	broad.mit.edu	37	chr16	2028594	2028594	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaggaccctccaggccgccGctttcttggacttcctgtgg	4	10	12	15	2	1	0	0	0	1	0	3	2	3	2	5	4	0	2	5	4	0	3	rs147301648	byFrequency	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:2028594G>C	uc002cnu.1	+	22	2437	c.2335G>C	c.(2335-2337)GCT>CCT	p.A779P	TBL3_uc002cnv.1_Missense_Mutation_p.A665P|TBL3_uc010bsc.1_Missense_Mutation_p.A646P|TBL3_uc010uvt.1_Missense_Mutation_p.A248P|TBL3_uc002cnw.1_RNA	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	779					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0						CCAGGCCGCCGCTTTCTTGGA	0.672													31	74					0	0	0	0	C	2028594	C	C	2028594	3	2	34	1	0	0	0	0	1	0	0	0	15709	1087	38	3	2421	3	TBL3	16	2028594	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	66759	2028594	88326159	320	6612											
AMDHD2	51005	broad.mit.edu	37	chr16	2579489	2579489	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccagacttcgtggtgctCgacgactcccttcacgtcca	6	10	9	16	4	1	1	1	0	0	1	6	3	4	1	3	1	1	1	3	1	0	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:2579489C>A	uc002cqq.2	+	11	1252	c.1155C>A	c.(1153-1155)CTC>CTA	p.L385L	AMDHD2_uc002cqp.2_Silent_p.L415L|AMDHD2_uc010uwc.1_Silent_p.L415L|AMDHD2_uc010uwd.1_Silent_p.L179L	NM_015944	NP_057028	Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2 isoform 1	385					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			skin(2)|large_intestine(1)|breast(1)	4						TCGTGGTGCTCGACGACTCCC	0.657													45	197					7.89702e-26	1.06015e-25	1	0	A	2579489	A	A	2579489	2	1	34	1	0	0	0	0	0	0	0	1	568	871	31	3		3	AMDHD2	16	2579489	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	550895	2579489	87775264	321	6613											
SCNN1G	6340	broad.mit.edu	37	chr16	23200940	23200940	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cggcggtagcatcattcacaAggcttcaaatgtcatgcaca	12	9	9	11	2	4	0	4	0	0	0	4	0	4	0	0	3	2	4	0	3	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:23200940A>G	uc002dlm.1	+	3	705	c.566A>G	c.(565-567)AAG>AGG	p.K189R		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	189	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	ATCATTCACAAGGCTTCAAAT	0.512													97	283					0	0	0	0	G	23200940	G	G	23200940	3	3	34	1	0	0	0	0	1	0	0	0	13995	72	3	5	572	5	SCNN1G	16	23200940	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	20621451	23200940	67153813	322	6614											
PRKCB	5579	broad.mit.edu	37	chr16	24192159	24192159	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattctgagggacacatcaaGattgccgattttggcatgtg	10	12	12	7	1	2	2	1	1	1	1	2	5	2	3	1	2	1	1	1	2	1	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:24192159G>C	uc002dmd.2	+	13	1640	c.1443G>C	c.(1441-1443)AAG>AAC	p.K481N	PRKCB_uc002dme.2_Missense_Mutation_p.K481N	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	481	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	GACACATCAAGATTGCCGATT	0.453													36	125					0	0	0	0	C	24192159	C	C	24192159	3	2	34	1	0	0	0	0	1	0	0	0	12570	933	33	2	1493	2	PRKCB	16	24192159	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	991219	24192159	66162594	323	6615											
HS3ST4	9951	broad.mit.edu	37	chr16	26146942	26146942	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctctcctagaaatgtgatGcccaagactttggatgggca	10	10	10	11	0	1	3	0	1	1	2	2	4	1	4	3	2	1	1	3	2	3	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:26146942G>T	uc002dof.2	+	2	1136	c.744G>T	c.(742-744)ATG>ATT	p.M248I		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	248	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		GAAATGTGATGCCCAAGACTT	0.423													6	23					2.7689e-08	3.04206e-08	1	0	T	26146942	T	T	26146942	3	4	34	1	0	0	0	0	1	0	0	0	7406	1319	46	4	750	4	HS3ST4	16	26146942	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1954783	26146942	64207811	324	6616											
HEATR3	55027	broad.mit.edu	37	chr16	50118095	50118095	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctagcagtgatgaaagtgacGcatttatggagaattccttc	12	12	10	7	1	0	4	0	3	0	1	2	5	1	4	1	1	1	2	1	1	4	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:50118095G>A	uc002efw.2	+	9	1345	c.1183G>A	c.(1183-1185)GCA>ACA	p.A395T	HEATR3_uc002efx.2_Missense_Mutation_p.A309T	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	395							binding			ovary(1)|skin(1)	2						TGAAAGTGACGCATTTATGGA	0.502													19	67					0	0	0	0	A	50118095	A	A	50118095	3	1	34	1	0	0	0	0	1	0	0	0	7068	1087	38	1	1217	1	HEATR3	16	50118095	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	23971153	50118095	40236658	325	6617											
NUP93	9688	broad.mit.edu	37	chr16	56855500	56855500	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccgtcgcagagctcgatGataaggtagcacctagagct	10	9	11	11	3	0	3	0	1	0	2	3	4	1	3	2	1	3	5	2	1	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:56855500G>T	uc002eka.2	+	7	770	c.649G>T	c.(649-651)GAT>TAT	p.D217Y	NUP93_uc002ekb.2_Missense_Mutation_p.D94Y|NUP93_uc010vhi.1_Missense_Mutation_p.D94Y	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	217					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						AGAGCTCGATGATAAGGTAGC	0.458													22	68					2.21704e-12	2.59271e-12	1	0	T	56855500	T	T	56855500	3	4	34	1	0	0	0	0	1	0	0	0	10826	1290	45	2	671	2	NUP93	16	56855500	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	6737405	56855500	33499253	326	6618											
CKLF	51192	broad.mit.edu	37	chr16	66597056	66597056	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcactggtaacaacagtatTcatgctcatcgtatctgtgt	10	14	7	10	1	4	0	3	0	1	0	5	0	4	0	0	1	3	4	0	1	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:66597056T>C	uc002eow.2	+	3	416	c.269T>C	c.(268-270)TTC>TCC	p.F90S	CKLF_uc002eox.1_Missense_Mutation_p.F90S|CKLF_uc002eot.2_Intron|CKLF_uc002eou.2_Missense_Mutation_p.F37S|CKLF_uc002eov.2_Intron	NM_016951	NP_058647	Q9UBR5	CKLF_HUMAN	chemokine-like factor isoform a	90	Helical; (Potential).|MARVEL.				cell proliferation|lymphocyte chemotaxis|macrophage chemotaxis|neutrophil chemotaxis|secretion by cell	extracellular space|integral to membrane	chemokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0689)|Epithelial(162;0.217)		ACAACAGTATTCATGCTCATC	0.378													23	60					0	0	0	0	C	66597056	C	C	66597056	3	2	34	1	0	0	0	0	1	0	0	0	3462	1783	62	5	279	5	CKLF	16	66597056	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	9741556	66597056	23757697	327	6619											
ELMO3	79767	broad.mit.edu	37	chr16	67233226	67233226	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aggcgcccacgtcccagctgGaccatggcgcctccgcggaa	7	4	13	17	5	0	0	0	0	0	0	2	2	2	2	5	4	1	1	5	4	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:67233226G>C	uc002esa.2	+	1	199	c.156G>C	c.(154-156)TGG>TGC	p.W52C	ELMO3_uc002esb.2_Missense_Mutation_p.W52C|ELMO3_uc002esc.2_5'Flank	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	Error:Variant_position_missing_in_Q96BJ8_after_alignment					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		GTCCCAGCTGGACCATGGCGC	0.682													9	34					0	0	0	0	C	67233226	C	C	67233226	3	2	34	1	0	0	0	0	1	0	0	0	5091	1183	41	2	158	2	ELMO3	16	67233226	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	636170	67233226	23121527	328	6620											
MARVELD3	91862	broad.mit.edu	37	chr16	71668581	71668581	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagtttccacggagcagatAtaggagctggaatctttgct	10	11	12	8	1	1	1	0	0	1	1	2	4	2	4	1	3	3	5	1	3	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:71668581A>G	uc002fat.2	+	3	1144	c.1081A>G	c.(1081-1083)ATA>GTA	p.I361V	MARVELD3_uc002fau.2_Intron|MARVELD3_uc010cge.2_Intron	NM_052858	NP_443090	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 2	361	MARVEL.|Helical; (Potential).					integral to membrane				skin(1)	1		Ovarian(137;0.125)				CGGAGCAGATATAGGAGCTGG	0.537													11	45					0	0	0	0	G	71668581	G	G	71668581	3	3	34	1	0	0	0	0	1	0	0	0	9372	449	16	5	1091	5	MARVELD3	16	71668581	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	4435355	71668581	18686172	329	6621											
CDYL2	124359	broad.mit.edu	37	chr16	80654697	80654697	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgagtgctctcctttcgccGgtcgctggacaaccggccaa	6	8	11	16	5	1	0	0	0	1	0	4	2	1	1	5	3	2	2	5	3	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr16:80654697G>T	uc002ffs.2	-	4	1075	c.970C>A	c.(970-972)CGG>AGG	p.R324R		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	324						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						TCCTTTCGCCGGTCGCTGGAC	0.522													9	44					0.00621372	0.00631685	1	0	T	80654697	T	T	80654697	2	4	34	1	0	0	0	0	0	0	0	1	3201	1115	39	3		3	CDYL2	16	80654697	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	8986116	80654697	9700056	330	6622											
MYBBP1A	10514	broad.mit.edu	37	chr17	4448119	4448119	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtctcgccgggcctggataCgcagcttctgctcggcaaag	6	8	13	14	5	2	0	0	0	2	0	4	1	2	1	2	3	3	4	2	3	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:4448119C>A	uc002fyb.3	-	18	2470	c.2408G>T	c.(2407-2409)CGT>CTT	p.R803L	MYBBP1A_uc002fxz.3_Missense_Mutation_p.R803L|MYBBP1A_uc002fya.3_5'Flank|MYBBP1A_uc010vsa.1_5'Flank	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	803					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						GGCCTGGATACGCAGCTTCTG	0.657													8	5					0.00448238	0.00457576	1	0	A	4448119	A	A	4448119	3	1	34	1	0	0	0	0	1	0	0	0	10061	536	19	3	1654	3	MYBBP1A	17	4448119	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08		4448119	76747091	331	6623											
TP53	7157	broad.mit.edu	37	chr17	7577121	7577121	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccaggacaggcacaaacacGcacctcaaagctgttccgtc	12	5	8	16	2	1	0	1	0	0	0	3	1	2	1	3	2	2	4	3	2	2	1	rs121913343		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:7577121G>T	uc002gim.2	-	8	1011	c.817C>A	c.(817-819)CGT>AGT	p.R273S	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141S|TP53_uc010cng.1_Missense_Mutation_p.R141S|TP53_uc002gii.1_Missense_Mutation_p.R141S|TP53_uc010cnh.1_Missense_Mutation_p.R273S|TP53_uc010cni.1_Missense_Mutation_p.R273S|TP53_uc002gij.2_Missense_Mutation_p.R273S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	14					5.4927e-09	6.0892e-09	1	0	T	7577121	T	T	7577121	3	4	34	1	0	0	0	0	1	0	0	0	16448	1087	38	3	469	3	TP53	17	7577121	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	3129002	7577121	73618089	332	6624											
DNAH2	146754	broad.mit.edu	37	chr17	7663202	7663202	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctctgtcttctgccacctcCctgacattctcaccaagcgc	6	12	5	18	1	4	1	1	1	4	0	7	1	5	1	4	0	2	0	4	0	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:7663202C>A	uc002giu.1	+	16	2745	c.2731C>A	c.(2731-2733)CCT>ACT	p.P911T		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	911	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTGCCACCTCCCTGACATTCT	0.537													71	195					1.20873e-29	1.64522e-29	1	0	A	7663202	A	A	7663202	3	1	34	1	0	0	0	0	1	0	0	0	4624	623	22	4	2793	4	DNAH2	17	7663202	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	86081	7663202	73532008	333	6625											
USP43	124739	broad.mit.edu	37	chr17	9596531	9596531	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggacagtcggcccctctgtCactgggcagttgacaggtaa	9	8	13	11	1	2	1	1	1	1	0	3	2	2	2	2	4	0	3	2	4	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:9596531C>T	uc010cod.2	+	9	1441	c.1441C>T	c.(1441-1443)CAC>TAC	p.H481Y	USP43_uc002gma.3_Missense_Mutation_p.H170Y|USP43_uc010vva.1_Missense_Mutation_p.H481Y|USP43_uc010coe.2_Missense_Mutation_p.H278Y	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	481					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCCCCTCTGTCACTGGGCAGT	0.507													5	10					0	0	0	0	T	9596531	T	T	9596531	3	4	34	1	0	0	0	0	1	0	0	0	17142	826	29	2	1475	2	USP43	17	9596531	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1933329	9596531	71598679	334	6626											
MPRIP	23164	broad.mit.edu	37	chr17	17030066	17030066	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgaaccagtgcacagatgtGgtggatggggagggccgcac	10	6	17	8	1	0	2	0	1	0	1	0	4	0	4	2	5	2	2	2	5	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:17030066G>A	uc002gqu.1	+	4	374	c.318G>A	c.(316-318)GTG>GTA	p.V106V	MPRIP_uc002gqv.1_Silent_p.V106V	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	106	Interaction with F-actin (By similarity).|PH 1.					cytoplasm|cytoskeleton	actin binding				0						GCACAGATGTGGTGGATGGGG	0.602													19	69					0	0	0	0	A	17030066	A	A	17030066	2	1	34	1	0	0	0	0	0	0	0	1	9796	1335	47	4		4	MPRIP	17	17030066	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	7433535	17030066	64165144	335	6627											
FLOT2	2319	broad.mit.edu	37	chr17	27211325	27211325	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctgcaacgtcataatctctAgggaaatcctgccaagaaac	14	8	8	11	1	2	1	1	0	1	1	4	2	3	2	2	1	4	2	2	1	6	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:27211325A>G	uc002hdc.2	-	3	263	c.140T>C	c.(139-141)CTA>CCA	p.L47P		NM_004475	NP_004466	Q14254	FLOT2_HUMAN	flotillin 2	47					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction					0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			CATAATCTCTAGGGAAATCCT	0.602													27	65					0	0	0	0	G	27211325	G	G	27211325	3	3	34	1	0	0	0	0	1	0	0	0	5969	420	15	5	1182	5	FLOT2	17	27211325	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	10181259	27211325	53983885	336	6628											
SLFN11	91607	broad.mit.edu	37	chr17	33690816	33690816	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccacaaccagggggcactgaTttgcctccatgttgaactca	10	9	9	13	0	1	2	1	2	0	0	2	2	2	2	4	2	3	2	4	2	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:33690816T>A	uc010ctp.2	-	4	453	c.11A>T	c.(10-12)AAT>ATT	p.N4I	SLFN11_uc010ctq.2_Missense_Mutation_p.N4I|SLFN11_uc002hjh.3_Missense_Mutation_p.N4I|SLFN11_uc002hjg.3_Missense_Mutation_p.N4I|SLFN11_uc010ctr.2_Missense_Mutation_p.N4I	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	4						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGGGCACTGATTTGCCTCCAT	0.343													20	59					0	0	0	0	A	33690816	A	A	33690816	3	1	34	1	0	0	0	0	1	0	0	0	14797	1493	52	5	2710	5	SLFN11	17	33690816	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	6479491	33690816	47504394	337	6629											
SYNRG	11276	broad.mit.edu	37	chr17	35914140	35914140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcatcagttcctgcagatCtgaattctgcaaagctttct	10	14	6	11	0	5	2	2	1	3	1	6	2	6	2	1	0	3	4	1	0	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:35914140C>T	uc002hoa.2	-	14	1768	c.1685G>A	c.(1684-1686)AGA>AAA	p.R562K	SYNRG_uc010wde.1_Missense_Mutation_p.R484K|SYNRG_uc010wdf.1_Missense_Mutation_p.R484K|SYNRG_uc002hoc.2_Missense_Mutation_p.R483K|SYNRG_uc002hoe.2_Missense_Mutation_p.R484K|SYNRG_uc002hod.2_Missense_Mutation_p.R484K|SYNRG_uc010wdg.1_Missense_Mutation_p.R401K|SYNRG_uc002hob.2_Missense_Mutation_p.R562K|SYNRG_uc002hof.2_Missense_Mutation_p.R274K|SYNRG_uc010cvd.1_Missense_Mutation_p.R362K	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	562	Interaction with A1P1G1 and A1P1G2.				endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						TCCTGCAGATCTGAATTCTGC	0.383													18	60					0	0	0	0	T	35914140	T	T	35914140	3	4	34	1	0	0	0	0	1	0	0	0	15526	913	32	2	2368	2	SYNRG	17	35914140	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2223324	35914140	45281070	338	6630											
STXBP4	252983	broad.mit.edu	37	chr17	53108627	53108627	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggacagtgtcttttggaggTaatattaggtttattgtgtt	8	18	13	2	0	1	0	0	0	1	0	1	2	1	2	0	4	0	3	0	4	4	9			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:53108627T>C	uc002iuf.1	+	9	970	c.763_splice	c.e9+2	p.D255_splice	STXBP4_uc010dcc.1_Splice_Site_p.D180_splice|STXBP4_uc010dcd.1_Splice_Site_p.D255_splice	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4							cytoplasm	calcium ion binding			ovary(1)	1						CTTTTGGAGGTAATATTAGGT	0.378													13	20					0	0	0	0	C	53108627	C	C	53108627	5	2	34	1	0	0	0	0	0	0	1	0	15421	1652	57	5	791	5	STXBP4	17	53108627	Splice_Site	SNP	T	TCGA-BB-7871-01A-11D-2229-08	17194487	53108627	28086583	339	6631											
MPO	4353	broad.mit.edu	37	chr17	56349015	56349015	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acgacgcctgcccctcctcaCcgatcaccatcccggagctt	7	7	7	20	4	2	0	2	0	0	0	4	3	4	1	7	1	2	1	7	1	0	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:56349015C>T	uc002ivu.1	-	11	2207	c.2030_splice	c.e11+1	p.R677_splice		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase						anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CCCCTCCTCACCGATCACCAT	0.642													14	41					0	0	0	0	T	56349015	T	T	56349015	5	4	34	1	0	0	0	0	0	0	1	0	9785	521	18	4	214	4	MPO	17	56349015	Splice_Site	SNP	C	TCGA-BB-7871-01A-11D-2229-08	3240388	56349015	24846195	340	6632											
PPM1E	22843	broad.mit.edu	37	chr17	57058234	57058234	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacaaaataggcactagcCtgtcctcacttactggaagt	12	9	7	13	0	1	0	1	0	0	0	2	1	2	1	3	2	2	1	3	2	6	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:57058234C>T	uc002iwx.2	+	7	2237	c.2110C>T	c.(2110-2112)CTG>TTG	p.L704L	PPM1E_uc010ddd.2_Silent_p.L467L	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	713					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			AGGCACTAGCCTGTCCTCACT	0.433													13	44					0	0	0	0	T	57058234	T	T	57058234	2	4	34	1	0	0	0	0	0	0	0	1	12398	680	24	4		4	PPM1E	17	57058234	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	709219	57058234	24136976	341	6633											
GDPD1	284161	broad.mit.edu	37	chr17	57298104	57298104	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcagtaaacacatctctcAccgcggaggtgagaggggtc	10	7	12	12	2	3	1	2	1	1	1	5	3	3	2	2	4	1	1	2	4	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:57298104A>G	uc002ixk.1	+	1	271	c.134A>G	c.(133-135)CAC>CGC	p.H45R	GDPD1_uc002ixj.2_Missense_Mutation_p.H45R	NM_182569	NP_872375	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain	45	Cytoplasmic (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					CACATCTCTCACCGCGGAGGT	0.572											OREG0024617	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	76					0	0	0	0	G	57298104	G	G	57298104	3	3	34	1	0	0	0	0	1	0	0	0	6360	159	6	5	136	5	GDPD1	17	57298104	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	239870	57298104	23897106	342	6634											
GH2	2689	broad.mit.edu	37	chr17	61957807	61957807	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcagtgcgtcatcgttgtgCgattttgtgtcaaacttgct	7	15	11	8	3	2	0	2	0	0	0	3	1	2	0	0	0	5	3	0	0	1	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:61957807C>T	uc002jco.1	-	5	590	c.528G>A	c.(526-528)TCG>TCA	p.S176S	GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_3'UTR|GH2_uc002jcm.1_Missense_Mutation_p.R175H|GH2_uc002jcn.1_Silent_p.S161S	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	176						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						CATCGTTGTGCGATTTTGTGT	0.542													30	133					0	0	0	0	T	61957807	T	T	61957807	2	4	34	1	0	0	0	0	0	0	0	1	6405	768	27	1		1	GH2	17	61957807	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	4659703	61957807	19237403	343	6635											
ST6GALNAC1	55808	broad.mit.edu	37	chr17	74625132	74625132	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcgaagctgtatttttcctCaaaatcccaccgaggctcag	10	12	7	12	2	2	0	2	0	0	0	5	2	4	0	3	1	1	3	3	1	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:74625132C>T	uc002jsh.2	-	2	967	c.793G>A	c.(793-795)GAG>AAG	p.E265K	ST6GALNAC1_uc002jsi.2_Missense_Mutation_p.E133K|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	265	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						TATTTTTCCTCAAAATCCCAC	0.567													34	92					0	0	0	0	T	74625132	T	T	74625132	3	4	34	1	0	0	0	0	1	0	0	0	15289	835	29	2	1041	2	ST6GALNAC1	17	74625132	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	12667325	74625132	6570078	344	6636			1	7		5	5	359	C		2.542227e-11
ST6GALNAC1	55808	broad.mit.edu	37	chr17	74625172	74625172	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatttgaagttggcggccttCagtctttggtttctctgcgt	4	17	12	8	2	3	1	1	1	2	0	4	2	3	1	1	3	1	2	1	3	1	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:74625172C>T	uc002jsh.2	-	2	927	c.753G>A	c.(751-753)CTG>CTA	p.L251L	ST6GALNAC1_uc002jsi.2_Silent_p.L119L|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	251	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						TGGCGGCCTTCAGTCTTTGGT	0.547													23	66					0	0	0	0	T	74625172	T	T	74625172	2	4	34	1	0	0	0	0	0	0	0	1	15289	813	29	2		2	ST6GALNAC1	17	74625172	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	40	74625172	6570038	345	6637			1	7		5	5	359	C		2.542227e-11
ST6GALNAC1	55808	broad.mit.edu	37	chr17	74625281	74625281	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtggtcactcctttctgtCtcgtccttgttgacactgct	3	17	8	13	1	3	1	1	1	2	0	6	1	5	1	2	1	1	2	2	1	0	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:74625281C>G	uc002jsh.2	-	2	818	c.644G>C	c.(643-645)AGA>ACA	p.R215T	ST6GALNAC1_uc002jsi.2_Missense_Mutation_p.R83T|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	215	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						TCCTTTCTGTCTCGTCCTTGT	0.577													18	86					0	0	0	0	G	74625281	G	G	74625281	3	3	34	1	0	0	0	0	1	0	0	0	15289	913	32	2	1190	2	ST6GALNAC1	17	74625281	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	109	74625281	6569929	346	6638			1	7		5	5	359	C		2.542227e-11
ST6GALNAC1	55808	broad.mit.edu	37	chr17	74625381	74625381	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgctttgccctggtgcttctCtgacaccgtcctggaggccg	3	11	12	15	3	1	1	0	1	1	0	3	2	2	2	4	3	2	2	4	3	0	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:74625381C>G	uc002jsh.2	-	2	718	c.544G>C	c.(544-546)GAG>CAG	p.E182Q	ST6GALNAC1_uc002jsi.2_Missense_Mutation_p.E50Q|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	182	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						TGGTGCTTCTCTGACACCGTC	0.577													43	157					0	0	0	0	G	74625381	G	G	74625381	3	3	34	1	0	0	0	0	1	0	0	0	15289	922	32	2	1290	2	ST6GALNAC1	17	74625381	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	100	74625381	6569829	347	6639			1	7		5	5	359	C		2.542227e-11
ST6GALNAC1	55808	broad.mit.edu	37	chr17	74625490	74625490	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tctgtcctgccagaggccatCcctgcatcttgccctctggg	4	11	10	16	0	3	1	0	0	3	1	5	1	5	1	5	2	3	1	5	2	0	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:74625490C>G	uc002jsh.2	-	2	609	c.435G>C	c.(433-435)GGG>GGC	p.G145G	ST6GALNAC1_uc002jsi.2_Silent_p.G13G|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	145	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						CAGAGGCCATCCCTGCATCTT	0.572													30	126					0	0	0	0	G	74625490	G	G	74625490	2	3	34	1	0	0	0	0	0	0	0	1	15289	842	30	2		2	ST6GALNAC1	17	74625490	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	109	74625490	6569720	348	6640			1	7		5	5	359	C		2.542227e-11
TNRC6C	57690	broad.mit.edu	37	chr17	76082941	76082941	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctgcctgccaggttgcgcGcacaatcactaatctgcagc	8	9	9	15	2	3	0	1	0	2	0	3	0	3	0	2	1	5	3	2	1	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:76082941G>A	uc002jud.2	+	14	4169	c.3569G>A	c.(3568-3570)CGC>CAC	p.R1190H	TNRC6C_uc002juf.2_Missense_Mutation_p.R1187H	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1190	Potential.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CAGGTTGCGCGCACAATCACT	0.592													52	241					0	0	0	0	A	76082941	A	A	76082941	3	1	34	1	0	0	0	0	1	0	0	0	16408	1087	38	1	3611	1	TNRC6C	17	76082941	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1457451	76082941	5112269	349	6641											
CYTH1	9267	broad.mit.edu	37	chr17	76694411	76694411	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtgagtgaggtcattccCgtcgtcttctgggattttaa	7	15	12	7	2	3	2	1	2	2	0	5	3	4	3	1	2	0	0	1	2	1	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:76694411C>A	uc002jvw.2	-	9	822	c.751G>T	c.(751-753)GGG>TGG	p.G251W	CYTH1_uc010wtw.1_Missense_Mutation_p.G192W|CYTH1_uc010wtx.1_Missense_Mutation_p.G192W	NM_017456	NP_059430	Q15438	CYH1_HUMAN	cytohesin 1 isoform 2	251					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						AGGTCATTCCCGTCGTCTTCT	0.413													50	176					5.47352e-35	7.6411e-35	1	0	A	76694411	A	A	76694411	3	1	34	1	0	0	0	0	1	0	0	0	4220	652	23	3	465	3	CYTH1	17	76694411	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	611470	76694411	4500799	350	6642											
CCDC40	55036	broad.mit.edu	37	chr17	78013758	78013758	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcagcagtggaaggggaaGaggaggctgtgtcctatgga	12	6	18	5	0	0	1	0	0	0	1	1	5	1	5	1	6	2	3	1	6	4	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:78013758G>A	uc010dht.2	+	3	268	c.241G>A	c.(241-243)GAG>AAG	p.E81K	CCDC40_uc010wub.1_Missense_Mutation_p.E81K	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	81					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			ggaaggggaagaggaggCTGT	0.353													14	56					0	0	0	0	A	78013758	A	A	78013758	3	1	34	1	0	0	0	0	1	0	0	0	2825	943	33	2	251	2	CCDC40	17	78013758	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1319347	78013758	3181452	351	6643											
CD7	924	broad.mit.edu	37	chr17	80275332	80275332	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggccgcgagccagcgccaGaagcaggggcagcagcagga	11	0	17	13	3	0	1	0	0	0	1	0	3	0	2	3	4	5	4	3	4	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr17:80275332G>C	uc002kel.1	-	1	149	c.40C>G	c.(40-42)CTG>GTG	p.L14V	CD7_uc010din.2_Missense_Mutation_p.L14V|CD7_uc002kem.2_5'UTR|CD7_uc010wvk.1_Missense_Mutation_p.L14V	NM_006137	NP_006128	P09564	CD7_HUMAN	CD7 antigen precursor	14					immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)			GCCAGCGCCAGAAGCAGGGGC	0.692													4	11					0	0	0	0	C	80275332	C	C	80275332	3	2	34	1	0	0	0	0	1	0	0	0	3047	933	33	2	698	2	CD7	17	80275332	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2261574	80275332	919878	352	6644											
RALBP1	10928	broad.mit.edu	37	chr18	9517250	9517250	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgttttccgtgaatgtataGattacgtagagaagtatggc	11	13	11	6	3	0	3	0	1	0	2	1	4	1	3	2	1	1	4	2	1	7	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr18:9517250G>T	uc002kob.2	+	3	875	c.652G>T	c.(652-654)GAT>TAT	p.D218Y	RALBP1_uc002koc.2_Missense_Mutation_p.D218Y	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	218	Rho-GAP.				chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1						TGAATGTATAGATTACGTAGA	0.413													17	34					6.33239e-15	7.69943e-15	1	0	T	9517250	T	T	9517250	3	4	34	1	0	0	0	0	1	0	0	0	13077	942	33	2	658	2	RALBP1	18	9517250	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08		9517250	68559998	353	6645											
ABHD3	171586	broad.mit.edu	37	chr18	19244105	19244105	+	Silent	SNP	G	A	A																															attgaaacccctgctgccagGaaaggagcagaagggtacag																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr18:19244105G>A	uc002ktl.2	-	5	782	c.642C>T	c.(640-642)TTC>TTT	p.F214F	ABHD3_uc002ktm.2_Intron|ABHD3_uc010xao.1_RNA|ABHD3_uc002ktk.2_5'UTR	NM_138340	NP_612213	Q8WU67	ABHD3_HUMAN	alpha/beta hydrolase domain containing protein	214						integral to membrane	carboxylesterase activity			central_nervous_system(1)	1						CTGCTGCCAGGAAAGGAGCAG	0.448													10	24					0	0	0	0	A	19244105	A	A	19244105	2	1	34	1	0	0	0	0	0	0	0	1	83	1165	41	2		2	ABHD3	18	19244105	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	9726855	19244105	58833143	354	6646	11	2									
ABHD3	171586	broad.mit.edu	37	chr18	19244115	19244115	+	Missense_Mutation	SNP	G	A	A																															ctgctgccaggaaaggagcaGaagggtacaggctgtgtaca																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr18:19244115G>A	uc002ktl.2	-	5	772	c.632C>T	c.(631-633)TCT>TTT	p.S211F	ABHD3_uc002ktm.2_Intron|ABHD3_uc010xao.1_RNA|ABHD3_uc002ktk.2_5'UTR	NM_138340	NP_612213	Q8WU67	ABHD3_HUMAN	alpha/beta hydrolase domain containing protein	211						integral to membrane	carboxylesterase activity			central_nervous_system(1)	1						GAAAGGAGCAGAAGGGTACAG	0.443													11	27					0	0	0	0	A	19244115	A	A	19244115	3	1	34	1	0	0	0	0	1	0	0	0	83	942	33	2	617	2	ABHD3	18	19244115	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	10	19244115	58833133	355	6647	11	2									
MIB1	57534	broad.mit.edu	37	chr18	19427048	19427048	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgtcctgatccgaatctCtgcaaagcactggcaaagtg	10	10	9	12	1	2	1	0	1	2	0	5	2	4	1	2	1	2	3	2	1	3	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr18:19427048C>T	uc002ktq.2	+	16	2355	c.2355C>T	c.(2353-2355)CTC>CTT	p.L785L	MIB1_uc002ktp.2_Silent_p.L424L	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	785					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			ATCCGAATCTCTGCAAAGCAC	0.393													19	62					0	0	0	0	T	19427048	T	T	19427048	2	4	34	1	0	0	0	0	0	0	0	1	9619	900	32	2		2	MIB1	18	19427048	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	182933	19427048	58650200	356	6648											
NOL4	8715	broad.mit.edu	37	chr18	31684009	31684009	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatgtagatgtttttattttAcctcatcttgctgtgagttt	8	21	7	5	0	2	2	1	1	1	1	2	2	2	2	1	0	2	4	1	0	4	8			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr18:31684009A>G	uc010dmi.2	-	4	868	c.639_splice	c.e4+1	p.E213_splice	NOL4_uc002kxr.3_Splice_Site_p.E49_splice|NOL4_uc010xbt.1_Splice_Site_p.E139_splice|NOL4_uc010dmh.2_Splice_Site_p.E139_splice|NOL4_uc010xbu.1_Splice_Site_p.E213_splice|NOL4_uc002kxt.3_Splice_Site_p.E213_splice|NOL4_uc010xbw.1_Splice_Site_p.E99_splice	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4							nucleolus	RNA binding			ovary(3)	3						TTTTTATTTTACCTCATCTTG	0.373													20	39					0	0	0	0	G	31684009	G	G	31684009	5	3	34	1	0	0	0	0	0	0	1	0	10578	405	14	5	1307	5	NOL4	18	31684009	Splice_Site	SNP	A	TCGA-BB-7871-01A-11D-2229-08	12256961	31684009	46393239	357	6649											
INO80C	125476	broad.mit.edu	37	chr18	33077733	33077733	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcttactggcgccatagcCcccgccgctgctgccattgt	4	11	9	17	3	1	0	0	0	1	0	1	0	1	0	5	1	4	2	5	1	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr18:33077733C>T	uc002kyy.3	-	1	223	c.106G>A	c.(106-108)GGC>AGC	p.G36S	INO80C_uc002kyw.1_Missense_Mutation_p.G36S|INO80C_uc002kyx.3_5'Flank|INO80C_uc010dmt.2_Missense_Mutation_p.G36S	NM_194281	NP_919257	Q6PI98	IN80C_HUMAN	Ies6-similar protein isoform 2	36					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|MLL1 complex					0						GCGCCATAGCCCCCGCCGCTG	0.622													5	12					0	0	0	0	T	33077733	T	T	33077733	3	4	34	1	0	0	0	0	1	0	0	0	7787	623	22	4	608	4	INO80C	18	33077733	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1393724	33077733	44999515	358	6650											
GALNT1	2589	broad.mit.edu	37	chr18	33271142	33271142	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaattcaagaatttcttctAtataatttctccaggttagc	12	17	5	7	0	4	2	1	1	3	1	5	2	4	2	1	1	1	1	1	1	7	8			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr18:33271142A>G	uc010dmu.2	+	8	1198	c.1145A>G	c.(1144-1146)TAT>TGT	p.Y382C	GALNT1_uc002kyz.3_Missense_Mutation_p.Y322C|GALNT1_uc002kzb.2_Missense_Mutation_p.Y382C	NM_020474	NP_065207	Q10472	GALT1_HUMAN	polypeptide N-acetylgalactosaminyltransferase 1	382	Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						AATTTCTTCTATATAATTTCT	0.403													15	50					0	0	0	0	G	33271142	G	G	33271142	3	3	34	1	0	0	0	0	1	0	0	0	6242	449	16	5	1171	5	GALNT1	18	33271142	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	193409	33271142	44806106	359	6651											
KCNG2	26251	broad.mit.edu	37	chr18	77659643	77659643	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcttccacaccttttcgCgctcctactccgagctcaag	7	11	5	18	3	2	0	1	0	1	0	6	1	5	0	5	0	2	2	5	0	2	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr18:77659643C>T	uc010xfl.1	+	2	1228	c.1228C>T	c.(1228-1230)CGC>TGC	p.R410C		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	410	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CACCTTTTCGCGCTCCTACTC	0.697													11	34					0	0	0	0	T	77659643	T	T	77659643	3	4	34	1	0	0	0	0	1	0	0	0	8067	768	27	1	1234	1	KCNG2	18	77659643	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	44388501	77659643	417605	360	6652											
ABCA7	10347	broad.mit.edu	37	chr19	1062258	1062258	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagctgctgacgggccgcgaGcacctggagctgcttgcgcg	5	6	17	13	5	0	1	0	1	0	0	0	4	0	2	2	2	6	5	2	2	0	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:1062258G>A	uc002lqw.3	+	42	5889	c.5658G>A	c.(5656-5658)GAG>GAA	p.E1886E	ABCA7_uc002lqy.2_Silent_p.E339E|ABCA7_uc010dsc.2_RNA	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1886	ABC transporter 2.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGCCGCGAGCACCTGGAGC	0.692													79	164					0	0	0	0	A	1062258	A	A	1062258	2	1	34	1	0	0	0	0	0	0	0	1	37	962	34	4		4	ABCA7	19	1062258	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08		1062258	58066725	361	6653											
SIRT6	51548	broad.mit.edu	37	chr19	4174811	4174811	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcttgggggtgggcgggcGgggcaggggtggcagcgccc	3	4	24	10	3	0	0	0	0	0	0	0	0	0	0	1	9	2	3	1	9	0	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:4174811G>A	uc002lzo.2	-	8	931	c.871C>T	c.(871-873)CGC>TGC	p.R291C	SIRT6_uc002lzn.2_3'UTR|SIRT6_uc002lzp.2_3'UTR|SIRT6_uc010xid.1_Missense_Mutation_p.R219C|SIRT6_uc002lzq.2_Missense_Mutation_p.R264C|SIRT6_uc002lzr.2_Missense_Mutation_p.R192C	NM_016539	NP_057623	Q8N6T7	SIRT6_HUMAN	sirtuin 6	291	Pro-rich.				chromatin silencing|protein ADP-ribosylation	nuclear telomeric heterochromatin|nucleoplasm	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|protein binding|zinc ion binding			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.023)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGGCGGGCGGGGCAGGGGT	0.706													11	15					0	0	0	0	A	4174811	A	A	4174811	3	1	34	1	0	0	0	0	1	0	0	0	14407	1116	39	1	200	1	SIRT6	19	4174811	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	3112553	4174811	54954172	362	6654											
SHD	56961	broad.mit.edu	37	chr19	4280258	4280258	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggggactccaagaacccCggagatgccaagtatggttc	10	7	12	12	1	0	2	0	0	0	2	2	4	1	3	5	4	2	2	5	4	4	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:4280258C>A	uc002lzw.2	+	1	1661	c.198C>A	c.(196-198)CCC>CCA	p.P66P	SHD_uc010dtu.2_Silent_p.P66P	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	66											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAAGAACCCCGGAGATGCCA	0.672													6	18					3.59834e-05	3.78366e-05	1	0	A	4280258	A	A	4280258	2	1	34	1	0	0	0	0	0	0	0	1	14340	639	23	3		3	SHD	19	4280258	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	105447	4280258	54848725	363	6655											
MUC16	94025	broad.mit.edu	37	chr19	9075421	9075421	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatagtcaagaaggaattagGctctgttctagcccttgtag	12	12	10	7	0	3	1	1	0	2	1	3	2	3	2	1	2	1	3	1	2	8	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:9075421G>A	uc002mkp.2	-	3	12229	c.12025C>T	c.(12025-12027)CCT>TCT	p.P4009S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4011	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAGGAATTAGGCTCTGTTCTA	0.473													16	74					0	0	0	0	A	9075421	A	A	9075421	3	1	34	1	0	0	0	0	1	0	0	0	10026	1203	42	4	31826	4	MUC16	19	9075421	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	4795163	9075421	50053562	364	6656											
COL5A3	50509	broad.mit.edu	37	chr19	10071183	10071183	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccacaggggcagaaatccCgctcgagaagagctgaattc	12	6	11	12	2	0	4	0	1	0	3	4	5	2	4	2	2	1	3	2	2	3	1	rs144662581		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:10071183C>T	uc002mmq.1	-	67	5228	c.5142G>A	c.(5140-5142)GCG>GCA	p.A1714A		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1714	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GCAGAAATCCCGCTCGAGAAG	0.567													36	140					0	0	0	0	T	10071183	T	T	10071183	2	4	34	1	0	0	0	0	0	0	0	1	3713	639	23	1		1	COL5A3	19	10071183	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	995762	10071183	49057800	365	6657											
CARM1	10498	broad.mit.edu	37	chr19	11031564	11031564	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcccactacacatctccctcGgaaaacatgtggaacacggg	12	7	8	14	2	1	0	0	0	1	0	4	2	2	2	2	3	3	0	2	3	4	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:11031564G>C	uc002mpz.2	+	13	1605	c.1479G>C	c.(1477-1479)TCG>TCC	p.S493S	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_Silent_p.S276S	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	493					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						CATCTCCCTCGGAAAACATGT	0.657													66	144					0	0	0	0	C	11031564	C	C	11031564	2	2	34	1	0	0	0	0	0	0	0	1	2667	1103	39	3		3	CARM1	19	11031564	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	960381	11031564	48097419	366	6658											
ZNF700	90592	broad.mit.edu	37	chr19	12059494	12059494	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acatggtaatgcacagtgggGatggaacttataaatgtaaa	16	10	11	4	0	0	0	0	0	0	0	0	2	0	2	0	4	2	3	0	4	7	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:12059494G>T	uc002msu.2	+	4	781	c.655G>T	c.(655-657)GAT>TAT	p.D219Y	ZNF700_uc010xme.1_Missense_Mutation_p.D237Y|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	219					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCACAGTGGGGATGGAACTTA	0.378													33	68					1.2782e-34	1.77931e-34	1	0	T	12059494	T	T	12059494	3	4	34	1	0	0	0	0	1	0	0	0	18171	1174	41	2	669	2	ZNF700	19	12059494	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1027930	12059494	47069489	367	6659											
ZNF564	163050	broad.mit.edu	37	chr19	12637604	12637604	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atctccagtgtgcagtatcaTatgttttctaatccttttaa	10	18	5	8	0	3	0	1	0	2	0	5	0	4	0	2	0	1	3	2	0	4	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:12637604T>C	uc002mty.2	-	4	1528	c.1318A>G	c.(1318-1320)ATG>GTG	p.M440V	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	440	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGCAGTATCATATGTTTTCTA	0.393													98	149					0	0	0	0	C	12637604	C	C	12637604	3	2	34	1	0	0	0	0	1	0	0	0	18062	1406	49	5	347	5	ZNF564	19	12637604	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	578110	12637604	46491379	368	6660											
ZNF564	163050	broad.mit.edu	37	chr19	12638134	12638134	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgaaataaactggggcggTcaaaggcttttccacattcc	11	11	9	10	2	1	0	1	0	0	0	4	1	3	0	2	4	1	1	2	4	4	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:12638134T>A	uc002mty.2	-	4	998	c.788A>T	c.(787-789)GAC>GTC	p.D263V	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	263	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACTGGGGCGGTCAAAGGCTTT	0.393													42	50					0	0	0	0	A	12638134	A	A	12638134	3	1	34	1	0	0	0	0	1	0	0	0	18062	1667	58	5	877	5	ZNF564	19	12638134	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	530	12638134	46490849	369	6661											
NOTCH3	4854	broad.mit.edu	37	chr19	15295165	15295165	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagtgtaccctccatggcagGtgcagctgaaactccctgcc	8	8	10	15	0	0	1	0	1	0	0	2	1	2	1	4	2	5	4	4	2	2	1	rs34338511	byFrequency	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:15295165G>T	uc002nan.2	-	16	2583	c.2507C>A	c.(2506-2508)ACC>AAC	p.T836N	NOTCH3_uc002nao.1_Intron	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	836	Extracellular (Potential).|EGF-like 21; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TCCATGGCAGGTGCAGCTGAA	0.627													22	106					6.36457e-07	6.83913e-07	1	0	T	15295165	T	T	15295165	3	4	34	1	0	0	0	0	1	0	0	0	10604	1261	44	4	4530	4	NOTCH3	19	15295165	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2657031	15295165	43833818	370	6662											
ZNF99	7652	broad.mit.edu	37	chr19	22952081	22952081	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catgtccaggcattgccactCctccagagcgaattctatgg	9	10	9	13	1	1	1	0	0	1	1	4	2	4	1	4	2	2	1	4	2	2	3	rs149345966	by1000genomes	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:22952081C>A	uc010xrh.1	-	2	112	c.112G>T	c.(112-114)GAG>TAG	p.E38*		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CATTGCCACTCCTCCAGAGCG	0.403													40	46					2.26627e-22	2.97714e-22	1	0	A	22952081	A	A	22952081	4	1	34	1	0	0	0	0	0	1	0	0	18271	864	30	2	3024	2	ZNF99	19	22952081	Nonsense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	7656916	22952081	36176902	371	6663											
TIMM50	92609	broad.mit.edu	37	chr19	39976330	39976330	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtccctctcccacagatGatcatcgagcccaccagccc	8	7	6	20	1	2	2	1	1	1	1	5	3	3	2	6	0	2	0	6	0	0	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:39976330G>T	uc002olu.1	+	6	817	c.684G>T	c.(682-684)ATG>ATT	p.M228I	TIMM50_uc002olt.1_RNA|TIMM50_uc002olv.1_5'UTR	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50	125	Mitochondrial intermembrane (Potential).				mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			ovary(1)	1	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TCCCACAGATGATCATCGAGC	0.607													36	91					2.2871e-25	3.04532e-25	1	0	T	39976330	T	T	39976330	3	4	34	1	0	0	0	0	1	0	0	0	15979	1290	45	2	706	2	TIMM50	19	39976330	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	17024249	39976330	19152653	372	6664											
CEACAM3	1084	broad.mit.edu	37	chr19	42301849	42301849	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaagtcagatcttgtgaaTgaagaagcaactggacagtt	16	10	10	5	0	2	4	1	2	1	2	2	5	2	5	0	1	2	2	0	1	6	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:42301849T>A	uc002orn.1	+	2	469	c.393T>A	c.(391-393)AAT>AAA	p.N131K	CEACAM3_uc010eia.1_Missense_Mutation_p.N131K|CEACAM3_uc002oro.1_RNA	NM_001815	NP_001806	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion	131	Ig-like V-type.|Extracellular (Potential).					integral to membrane				skin(1)	1						ATCTTGTGAATGAAGAAGCAA	0.453													62	242					0	0	0	0	A	42301849	A	A	42301849	3	1	34	1	0	0	0	0	1	0	0	0	3208	1461	51	5	399	5	CEACAM3	19	42301849	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	2325519	42301849	16827134	373	6665											
TMEM145	284339	broad.mit.edu	37	chr19	42824523	42824523	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aatttcggcatccccaagtgGgcccgggagaagattgtcaa	11	8	12	10	2	1	2	1	0	0	2	3	3	2	2	3	3	0	1	3	3	4	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:42824523G>T	uc002otk.1	+	13	1180	c.1128G>T	c.(1126-1128)TGG>TGT	p.W376C		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	376						integral to membrane					0		Prostate(69;0.00682)				TCCCCAAGTGGGCCCGGGAGA	0.577													27	122					6.32553e-13	7.45075e-13	1	0	T	42824523	T	T	42824523	3	4	34	1	0	0	0	0	1	0	0	0	16125	1241	43	4	1178	4	TMEM145	19	42824523	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	522674	42824523	16304460	374	6666											
ZNF221	7638	broad.mit.edu	37	chr19	44470148	44470148	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagactatctataagtcacgTgcaacagaaaccttaccgtt	15	10	6	10	2	2	2	1	0	1	2	2	2	2	2	2	0	4	2	2	0	7	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:44470148T>C	uc002oxx.2	+	6	822	c.494T>C	c.(493-495)GTG>GCG	p.V165A	ZNF221_uc010ejb.1_Missense_Mutation_p.V165A|ZNF221_uc010xws.1_Missense_Mutation_p.V165A	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				ATAAGTCACGTGCAACAGAAA	0.418													29	87					0	0	0	0	C	44470148	C	C	44470148	3	2	34	1	0	0	0	0	1	0	0	0	17842	1696	59	5	508	5	ZNF221	19	44470148	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	1645625	44470148	14658835	375	6667											
ZNF233	353355	broad.mit.edu	37	chr19	44777835	44777835	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcagcacaggagagaaccTctacagatgtcaggtatatg	14	8	11	8	0	3	2	2	0	1	2	3	4	3	3	1	2	3	2	1	2	4	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:44777835T>A	uc002oyz.1	+	5	1149	c.1022T>A	c.(1021-1023)CTC>CAC	p.L341H	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.L156H	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	341					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				GGAGAGAACCTCTACAGATGT	0.512													10	20					0	0	0	0	A	44777835	A	A	44777835	3	1	34	1	0	0	0	0	1	0	0	0	17853	1551	54	5	1036	5	ZNF233	19	44777835	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	307687	44777835	14351148	376	6668											
BCL2L12	83596	broad.mit.edu	37	chr19	50172114	50172114	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttttcaccccaggcccagCtactccagacttctatgctt	7	13	5	16	0	3	1	1	0	2	1	4	1	4	1	4	1	3	2	4	1	2	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:50172114C>T	uc002ppa.2	+	4	1191	c.509C>T	c.(508-510)GCT>GTT	p.A170V	IRF3_uc010end.1_5'Flank|IRF3_uc002pox.1_5'Flank|IRF3_uc002poy.1_5'Flank|IRF3_uc002pou.2_5'Flank|IRF3_uc002pov.2_5'Flank|IRF3_uc002pow.2_5'Flank|IRF3_uc002poz.1_5'Flank|BCL2L12_uc002ppb.2_Missense_Mutation_p.A169V	NM_138639	NP_619580	Q9HB09	B2L12_HUMAN	BCL2-like 12 isoform 1	170					apoptosis					central_nervous_system(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		CCAGGCCCAGCTACTCCAGAC	0.557													49	179					0	0	0	0	T	50172114	T	T	50172114	3	4	34	1	0	0	0	0	1	0	0	0	1372	797	28	4	523	4	BCL2L12	19	50172114	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	5394279	50172114	8956869	377	6669											
ZNF528	84436	broad.mit.edu	37	chr19	52909866	52909866	+	Frame_Shift_Del	DEL	G	-	-																															aaatagcaaacgatccagacGgcagggagtgcatcaaaggt																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:52909866delG	uc002pzh.2	+	6	667	c.241delG	c.(241-243)GGCfs	p.G81fs	ZNF528_uc002pzi.2_5'UTR	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		CGATCCAGACGGCAGGGAGTG	0.428													---	---	---								-	52909866	-	-	52909866	7	5	34	1	0	1	0	1	0	0	0	0	18036	1116	39	0	251	0	ZNF528	19	52909866	Frame_Shift_Del	DEL	G	TCGA-BB-7871-01A-11D-2229-08	2737752	52909866	6219117	378	6670											
NLRP12	91662	broad.mit.edu	37	chr19	54314433	54314433	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagtgctccttcaccagcagGagccgggtgtaccggtggct	6	8	15	12	2	1	0	1	0	0	0	2	2	2	1	4	4	4	4	4	4	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:54314433G>T	uc002qch.3	-	3	700	c.480C>A	c.(478-480)CTC>CTA	p.L160L	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.L160L|NLRP12_uc002qcj.3_Silent_p.L160L|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.L160L	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	160					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TCACCAGCAGGAGCCGGGTGT	0.617													39	115					8.16904e-11	9.30891e-11	1	0	T	54314433	T	T	54314433	2	4	34	1	0	0	0	0	0	0	0	1	10528	1161	41	2		2	NLRP12	19	54314433	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1404567	54314433	4814550	379	6671											
LILRB3	11025	broad.mit.edu	37	chr19	54725882	54725882	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccgggggagctggtgttctCcttccttcatcagaacaaaa	9	11	10	11	1	3	1	2	0	1	1	6	2	5	2	3	3	2	2	3	3	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:54725882C>T	uc002qef.1	-	4	587	c.476G>A	c.(475-477)GGA>GAA	p.G159E	LILRB3_uc002qee.1_Missense_Mutation_p.G159E|LILRB3_uc002qeh.1_Missense_Mutation_p.G159E|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Missense_Mutation_p.G159E|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Missense_Mutation_p.G159E|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	159	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGGTGTTCTCCTTCCTTCAT	0.627													15	7					0	0	0	0	T	54725882	T	T	54725882	3	4	34	1	0	0	0	0	1	0	0	0	8833	855	30	2	1462	2	LILRB3	19	54725882	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	411449	54725882	4403101	380	6672											
LILRB2	10288	broad.mit.edu	37	chr19	54783338	54783338	+	Frame_Shift_Del	DEL	G	-	-																															gatggcgcgggacgacccacGggcatggggctgggagttca																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:54783338delG	uc002qfb.2	-	5	786	c.520delC	c.(520-522)CGTfs	p.R174fs	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Frame_Shift_Del_p.R174fs|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Frame_Shift_Del_p.R174fs|LILRB2_uc010yet.1_Frame_Shift_Del_p.R58fs|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	174	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GACGACCCACGGGCATGGGGC	0.582													---	---	---								-	54783338	-	-	54783338	7	5	34	1	0	1	0	1	0	0	0	0	8832	1116	39	0	1316	0	LILRB2	19	54783338	Frame_Shift_Del	DEL	G	TCGA-BB-7871-01A-11D-2229-08	57456	54783338	4345645	381	6673											
KIR2DS4	3809	broad.mit.edu	37	chr19	55351035	55351035	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcatcaacggaacattccAggccgactttcctctgggcc	9	8	9	15	2	2	0	1	0	1	0	4	2	4	1	4	3	3	1	4	3	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:55351035A>T	uc002qhm.1	+	5	591	c.545A>T	c.(544-546)CAG>CTG	p.Q182L	KIR2DS4_uc010yfj.1_Missense_Mutation_p.R168W|KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Missense_Mutation_p.R175W|KIR2DS4_uc002qhn.1_Intron	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	182	Extracellular (Potential).|Ig-like C2-type 2.					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		GGAACATTCCAGGCCGACTTT	0.587													39	85					0	0	0	0	T	55351035	T	T	55351035	3	4	34	1	0	0	0	0	1	0	0	0	8358	179	7	5	537	5	KIR2DS4	19	55351035	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	567697	55351035	3777948	382	6674											
NLRP7	199713	broad.mit.edu	37	chr19	55451293	55451293	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgggccgcgtggtgacCagcaaggctgccctgggtaa	6	6	16	13	2	0	1	0	1	0	0	0	1	0	1	4	4	2	3	4	4	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:55451293C>G	uc002qih.3	-	4	970	c.894G>C	c.(892-894)CTG>CTC	p.L298L	NLRP7_uc002qig.3_Silent_p.L298L|NLRP7_uc002qii.3_Silent_p.L298L|NLRP7_uc010esk.2_Silent_p.L298L|NLRP7_uc010esl.2_Silent_p.L326L	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	298	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GCGTGGTGACCAGCAAGGCTG	0.637													10	28					0	0	0	0	G	55451293	G	G	55451293	2	3	34	1	0	0	0	0	0	0	0	1	10536	581	21	4		4	NLRP7	19	55451293	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	100258	55451293	3677690	383	6675											
TNNT1	7138	broad.mit.edu	37	chr19	55658051	55658053	+	In_Frame_Del	DEL	TCC	-	-																															cggagtccgggacctcacctTcctcctcctcctccgcagcc																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:55658051_55658053delTCC	uc002qjb.3	-	4	158_160	c.69_71delGGA	c.(67-72)GAGGAA>GAA	p.23_24EE>E	TNNT1_uc002qiz.3_5'UTR|TNNT1_uc002qja.3_5'UTR|TNNT1_uc002qjc.3_In_Frame_Del_p.23_24EE>E|TNNT1_uc002qje.3_In_Frame_Del_p.23_24EE>E|TNNT1_uc002qjd.3_In_Frame_Del_p.23_24EE>E|TNNT1_uc002qjf.2_In_Frame_Del_p.23_24EE>E	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	23_24					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		GACCTCACCTTCCTCCTCCTCCT	0.724													---	---	---								-	55658053	-	-	55658051	7	5	34	1	0	1	0	1	0	0	0	0	16396	1783	62	0	809	0	TNNT1	19	55658051	In_Frame_Del	DEL	TCC	TCGA-BB-7871-01A-11D-2229-08	206758	55658051	3470932	384	6676											
ZNF667	63934	broad.mit.edu	37	chr19	56953709	56953709	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttccatcatgaattctcaTatgtagaataagggttgttc	11	16	7	7	0	2	2	2	1	1	1	5	2	3	2	1	1	0	3	1	1	5	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:56953709T>C	uc002qnd.2	-	5	817	c.655A>G	c.(655-657)ATG>GTG	p.M219V	ZNF667_uc010etl.2_Missense_Mutation_p.M1V|ZNF667_uc002qne.2_Missense_Mutation_p.M219V|ZNF667_uc010etm.2_Missense_Mutation_p.M162V	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	219	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TGAATTCTCATATGTAGAATA	0.368													37	68					0	0	0	0	C	56953709	C	C	56953709	3	2	34	1	0	0	0	0	1	0	0	0	18141	1406	49	5	1181	5	ZNF667	19	56953709	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	1295658	56953709	2175274	385	6677											
ZNF773	374928	broad.mit.edu	37	chr19	58018684	58018684	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agccttgttaaacatcagagGgttcacactggagcaaagcc	13	8	10	10	0	2	1	2	0	0	1	2	2	2	2	2	2	4	3	2	2	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:58018684G>T	uc002qox.2	+	4	1361	c.1221G>T	c.(1219-1221)AGG>AGT	p.R407S	ZNF547_uc002qpm.3_Intron|ZNF773_uc002qoy.2_Missense_Mutation_p.R406S|ZNF773_uc002qoz.2_Intron	NM_198542	NP_940944	Q6PK81	ZN773_HUMAN	zinc finger protein 773	407	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		AACATCAGAGGGTTCACACTG	0.418													24	58					2.79863e-10	3.14525e-10	1	0	T	58018684	T	T	58018684	3	4	34	1	0	0	0	0	1	0	0	0	18213	1223	43	4	1235	4	ZNF773	19	58018684	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1064975	58018684	1110299	386	6678											
ZNF135	7694	broad.mit.edu	37	chr19	58578254	58578254	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacactgagggccactgggaAtggagttgtgagagtctaga	11	8	16	6	0	1	3	0	2	1	2	1	7	1	5	1	3	0	1	1	3	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:58578254A>T	uc010yhq.1	+	5	534	c.438A>T	c.(436-438)GAA>GAT	p.E146D	ZNF135_uc002qre.2_Missense_Mutation_p.E134D|ZNF135_uc002qrd.1_Missense_Mutation_p.E92D|ZNF135_uc002qrf.2_Missense_Mutation_p.E92D|ZNF135_uc002qrg.2_Missense_Mutation_p.E104D|ZNF135_uc010yhr.1_5'UTR	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	146					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		GCCACTGGGAATGGAGTTGTG	0.542													20	36					0	0	0	0	T	58578254	T	T	58578254	3	4	34	1	0	0	0	0	1	0	0	0	17792	98	4	5	605	5	ZNF135	19	58578254	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	559570	58578254	550729	387	6679											
MZF1	7593	broad.mit.edu	37	chr19	59081858	59081858	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actggagggctccatcttctCtgataggacctcctggccct	6	11	10	14	0	2	1	0	1	2	0	5	3	4	3	4	4	0	1	4	4	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr19:59081858C>T	uc002qto.2	-	3	994	c.433G>A	c.(433-435)GAG>AAG	p.E145K	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Missense_Mutation_p.E145K|MZF1_uc010euu.1_Missense_Mutation_p.E186K	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	145					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		TCCATCTTCTCTGATAGGACC	0.597													7	25					0	0	0	0	T	59081858	T	T	59081858	3	4	34	1	0	0	0	0	1	0	0	0	10161	922	32	2	1787	2	MZF1	19	59081858	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	503604	59081858	47125	388	6680											
POFUT1	23509	broad.mit.edu	37	chr20	30803173	30803173	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaagctggcacccacccaCtggccccctgagaagcgggt	9	4	13	15	1	0	2	0	1	0	2	0	4	0	2	4	3	2	2	4	3	2	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr20:30803173C>A	uc002wxp.2	+	3	397	c.348C>A	c.(346-348)CAC>CAA	p.H116Q	POFUT1_uc002wxo.2_Missense_Mutation_p.H116Q|POFUT1_uc010ztt.1_Missense_Mutation_p.H8Q|POFUT1_uc010ztu.1_Intron	NM_015352	NP_056167	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1 isoform 1	116					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)	1			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CACCCACCCACTGGCCCCCTG	0.587													73	93					1.52223e-32	2.11301e-32	1	0	A	30803173	A	A	30803173	3	1	34	1	0	0	0	0	1	0	0	0	12238	564	20	4	358	4	POFUT1	20	30803173	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08		30803173	32222347	389	6681											
SPAG4	6676	broad.mit.edu	37	chr20	34208679	34208679	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgagaaatcggagattcAgactttccacctgcaggtgt	10	12	11	8	1	1	3	1	1	0	3	3	5	2	3	2	2	1	2	2	2	1	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr20:34208679A>G	uc002xdb.1	+	11	1268	c.1151A>G	c.(1150-1152)CAG>CGG	p.Q384R	SPAG4_uc010zvi.1_Missense_Mutation_p.Q307R	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	384	SUN.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			TCGGAGATTCAGACTTTCCAC	0.512													75	75					0	0	0	0	G	34208679	G	G	34208679	3	3	34	1	0	0	0	0	1	0	0	0	15046	188	7	5	1193	5	SPAG4	20	34208679	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	3405506	34208679	28816841	390	6682											
MATN4	8785	broad.mit.edu	37	chr20	43930020	43930020	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cttggcagtgacagaaatagGagcctggggaattgacgcag	12	7	15	7	1	0	3	0	2	0	1	0	5	0	5	1	4	1	2	1	4	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr20:43930020G>C	uc002xnn.2	-	4	894	c.707C>G	c.(706-708)TCC>TGC	p.S236C	MATN4_uc002xno.2_Intron|MATN4_uc002xnp.2_Intron|MATN4_uc010zwr.1_Missense_Mutation_p.S184C|MATN4_uc002xnr.1_Missense_Mutation_p.S236C	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	277	EGF-like 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				ACAGAAATAGGAGCCTGGGGA	0.572											OREG0025977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	75					0	0	0	0	C	43930020	C	C	43930020	3	2	34	1	0	0	0	0	1	0	0	0	9389	1174	41	2	1066	2	MATN4	20	43930020	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	9721341	43930020	19095500	391	6683											
ZNF334	55713	broad.mit.edu	37	chr20	45130308	45130308	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgatggtgagtcagggctGacttcctgcagtaggttctc	6	13	13	9	0	3	3	1	3	2	0	5	3	4	3	1	3	1	4	1	3	1	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr20:45130308G>C	uc002xsc.2	-	5	1854	c.1670C>G	c.(1669-1671)TCA>TGA	p.S557*	ZNF334_uc002xsa.2_Nonsense_Mutation_p.S580*|ZNF334_uc002xsb.2_Nonsense_Mutation_p.S519*|ZNF334_uc002xsd.2_Nonsense_Mutation_p.S519*|ZNF334_uc010ghl.2_Nonsense_Mutation_p.S556*	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	557	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				AGTCAGGGCTGACTTCCTGCA	0.448													46	170					0	0	0	0	C	45130308	C	C	45130308	4	2	34	1	0	0	0	0	0	1	0	0	17918	1294	45	2	376	2	ZNF334	20	45130308	Nonsense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1200288	45130308	17895212	392	6684											
TP53RK	112858	broad.mit.edu	37	chr20	45315596	45315596	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaagtgctgaaatgaaactCagcccaaagtctatgagcac	15	7	10	9	0	2	3	1	3	1	0	2	4	2	4	1	1	4	2	1	1	5	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr20:45315596C>G	uc002xsk.2	-	2	781	c.558G>C	c.(556-558)CTG>CTC	p.L186L	SLC13A3_uc002xsg.1_5'Flank|SLC13A3_uc010gho.1_5'Flank|TP53RK_uc002xsj.2_3'UTR	NM_033550	NP_291028	Q96S44	PRPK_HUMAN	p53-related protein kinase	186	Protein kinase.				lipopolysaccharide biosynthetic process	membrane|nucleus	ATP binding|p53 binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Myeloproliferative disorder(115;0.0122)				AAATGAAACTCAGCCCAAAGT	0.493													24	73					0	0	0	0	G	45315596	G	G	45315596	2	3	34	1	0	0	0	0	0	0	0	1	16457	813	29	2		2	TP53RK	20	45315596	Silent	SNP	C	TCGA-BB-7871-01A-11D-2229-08	185288	45315596	17709924	393	6685											
ZNF831	128611	broad.mit.edu	37	chr20	57766302	57766302	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcctccagccccgcgccccGctagtgacgggcagcctaga	6	4	13	18	4	0	2	0	1	0	1	1	2	1	2	7	2	2	2	7	2	2	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr20:57766302G>T	uc002yan.2	+	1	228	c.228G>T	c.(226-228)CCG>CCT	p.P76P		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	76	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CCCGCGCCCCGCTAGTGACGG	0.716													7	6					0.00198382	0.00202938	1	0	T	57766302	T	T	57766302	2	4	34	1	0	0	0	0	0	0	0	1	18252	1074	38	3		3	ZNF831	20	57766302	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	12450706	57766302	5259218	394	6686											
SLCO4A1	28231	broad.mit.edu	37	chr20	61288358	61288358	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgcttatgggcacggggtcGctggtgttcgcgctgcccca	3	10	15	13	4	0	0	0	0	0	0	2	0	0	0	2	4	2	5	2	4	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr20:61288358G>A	uc002ydb.1	+	2	757	c.552G>A	c.(550-552)TCG>TCA	p.S184S	SLCO4A1_uc002ydc.1_RNA	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	184	Helical; Name=3; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			GCACGGGGTCGCTGGTGTTCG	0.697													41	68					0	0	0	0	A	61288358	A	A	61288358	2	1	34	1	0	0	0	0	0	0	0	1	14793	1074	38	1		1	SLCO4A1	20	61288358	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	3522056	61288358	1737162	395	6687											
MYT1	4661	broad.mit.edu	37	chr20	62838988	62838988	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attttggatccaaccccatcGgcagcgccactgcctcctcc	7	9	7	18	2	0	0	0	0	0	0	4	1	3	1	7	2	3	1	7	2	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr20:62838988G>T	uc002yii.2	+	7	803	c.439G>T	c.(439-441)GGC>TGC	p.G147C	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	147					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CAACCCCATCGGCAGCGCCAC	0.557													35	167					6.70999e-13	7.86577e-13	1	0	T	62838988	T	T	62838988	3	4	34	1	0	0	0	0	1	0	0	0	10159	1116	39	3	457	3	MYT1	20	62838988	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	1550630	62838988	186532	396	6688											
TPTE	7179	broad.mit.edu	37	chr21	10920132	10920132	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcgctgtgggttttatcTgttcgcctttctccaaaata	6	19	7	9	2	2	0	0	0	2	0	5	0	2	0	2	1	0	3	2	1	4	7			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr21:10920132T>A	uc002yip.1	-	19	1490	c.1122A>T	c.(1120-1122)ACA>ACT	p.T374T	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.T356T|TPTE_uc002yir.1_Silent_p.T336T|TPTE_uc010gkv.1_Silent_p.T236T	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	374	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGTTTTATCTGTTCGCCTTT	0.378													14	42					0	0	0	0	A	10920132	A	A	10920132	2	1	34	1	0	0	0	0	0	0	0	1	16497	1567	55	5		5	TPTE	21	10920132	Silent	SNP	T	TCGA-BB-7871-01A-11D-2229-08		10920132	37209763	397	6689											
SLC37A1	54020	broad.mit.edu	37	chr21	43974185	43974185	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttaccagcactcaaaaggctAtgagaatggtacaaacagat	17	8	8	8	0	1	2	1	1	0	2	1	3	1	2	1	2	4	3	1	2	7	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr21:43974185A>T	uc002zbi.2	+	11	1194	c.782A>T	c.(781-783)TAT>TTT	p.Y261F	SLC37A1_uc002zbj.2_Missense_Mutation_p.Y261F	NM_018964	NP_061837	P57057	GLPT_HUMAN	solute carrier family 37 member 1	261					carbohydrate transport|transmembrane transport	integral to membrane					0						TCAAAAGGCTATGAGAATGGT	0.383													7	8					0	0	0	0	T	43974185	T	T	43974185	3	4	34	1	0	0	0	0	1	0	0	0	14661	449	16	5	816	5	SLC37A1	21	43974185	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	33054053	43974185	4155710	398	6690											
ITGB2	3689	broad.mit.edu	37	chr21	46308803	46308803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgaacttcaggcactcggCgcaggagctgcggggagcca	8	6	15	12	4	1	0	1	0	0	0	3	3	1	2	1	5	4	3	1	5	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr21:46308803C>T	uc002zgd.2	-	13	1929	c.1885G>A	c.(1885-1887)GCC>ACC	p.A629T	ITGB2_uc002zge.2_Missense_Mutation_p.A629T|ITGB2_uc002zgf.3_Missense_Mutation_p.A629T|ITGB2_uc011afl.1_Missense_Mutation_p.A551T|ITGB2_uc010gpw.2_Missense_Mutation_p.A572T|ITGB2_uc002zgg.2_Missense_Mutation_p.A629T	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	629	Extracellular (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	AGGCACTCGGCGCAGGAGCTG	0.692													14	29					0	0	0	0	T	46308803	T	T	46308803	3	4	34	1	0	0	0	0	1	0	0	0	7933	768	27	1	436	1	ITGB2	21	46308803	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2334618	46308803	1821092	399	6691											
ZDHHC8	29801	broad.mit.edu	37	chr22	20119514	20119515	+	Frame_Shift_Ins	INS	-	C	C																															ctcaaacccgccaagtacatINScccggtggccacggccgccg																										TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr22:20119514_20119515insC	uc002zrq.2	+	1	150_151	c.44_45insC	c.(43-45)ATCfs	p.I15fs	ZDHHC8_uc002zrr.1_Frame_Shift_Ins_p.I15fs	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	15	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					GCCAAGTACATCCCGGTGGCCA	0.653													---	---	---								C	20119515	C	C	20119514	7	5	34	1	0	1	1	0	0	0	0	0	17688	1435	50	0	46	0	ZDHHC8	22	20119514	Frame_Shift_Ins	INS	-	TCGA-BB-7871-01A-11D-2229-08		20119514	31185052	400	6692											
MB	4151	broad.mit.edu	37	chr22	36006993	36006993	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtgccaggggcttaatctCtgcctcatgatgccccttct	5	13	9	14	0	3	1	1	1	2	0	4	1	3	1	4	2	3	1	4	2	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr22:36006993C>G	uc003anz.2	-	2	336	c.256G>C	c.(256-258)GAG>CAG	p.E86Q	MB_uc003aoa.2_Missense_Mutation_p.E86Q|MB_uc003aob.2_Missense_Mutation_p.E86Q	NM_005368	NP_005359	P02144	MYG_HUMAN	myoglobin	86							heme binding|oxygen transporter activity				0						GGCTTAATCTCTGCCTCATGA	0.463													11	32					0	0	0	0	G	36006993	G	G	36006993	3	3	34	1	0	0	0	0	1	0	0	0	9394	922	32	2	216	2	MB	22	36006993	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	15887479	36006993	15297573	401	6693											
PRR5-ARHGAP8	553158	broad.mit.edu	37	chr22	45122513	45122513	+	Frame_Shift_Del	DEL	G	-	-																															gacaagattcgcttctatgaGggtgagtgtgggccccttgg																								rs28450358		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr22:45122513delG	uc003bfd.2	+	4	593	c.321delG	c.(319-321)GAGfs	p.E107fs	PRR5_uc003bew.1_Frame_Shift_Del_p.E98fs|PRR5_uc003bex.1_Frame_Shift_Del_p.E12fs|PRR5_uc010gzt.1_Frame_Shift_Del_p.E130fs|PRR5_uc010gzu.1_Frame_Shift_Del_p.E71fs|PRR5_uc003bey.1_Frame_Shift_Del_p.E98fs|PRR5_uc003bez.1_Frame_Shift_Del_p.E12fs|PRR5-ARHGAP8_uc003bfc.2_Frame_Shift_Del_p.E107fs|PRR5-ARHGAP8_uc011aqi.1_Frame_Shift_Del_p.E98fs|PRR5-ARHGAP8_uc011aqj.1_Frame_Shift_Del_p.E12fs|PRR5_uc003bfa.1_Frame_Shift_Del_p.R2fs|PRR5_uc003bfb.1_Frame_Shift_Del_p.E107fs|PRR5_uc003bfe.1_RNA|PRR5-ARHGAP8_uc003bfg.1_Frame_Shift_Del_p.E12fs	NM_181335	NP_851852			Rho GTPase activating protein 8 isoform 2											skin(2)	2						GCTTCTATGAGGGTGAGTGTG	0.622													---	---	---								-	45122513	-	-	45122513	7	5	34	1	0	1	0	1	0	0	0	0	12663	1014	35	0	308	0	PRR5-ARHGAP8	22	45122513	Frame_Shift_Del	DEL	G	TCGA-BB-7871-01A-11D-2229-08	9115520	45122513	6182053	402	6694											
NCAPH2	29781	broad.mit.edu	37	chr22	50960669	50960669	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggaaactctccggaagctgCagaggagggaggcaagtccc	11	5	15	10	1	1	1	0	0	1	1	3	5	2	5	2	5	3	3	2	5	3	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr22:50960669C>T	uc003blr.3	+	14	1344	c.1222C>T	c.(1222-1224)CAG>TAG	p.Q408*	NCAPH2_uc003blv.2_Nonsense_Mutation_p.Q408*|NCAPH2_uc010hbb.2_Intron|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Nonsense_Mutation_p.Q408*|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	408					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CCGGAAGCTGCAGAGGAGGGA	0.592													18	50					0	0	0	0	T	50960669	T	T	50960669	4	4	34	1	0	0	0	0	0	1	0	0	10264	711	25	4	1315	4	NCAPH2	22	50960669	Nonsense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	5838156	50960669	343897	403	6695			2	8		7	7	7058	C		1.162083e-09
NCAPH2	29781	broad.mit.edu	37	chr22	50961569	50961569	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccggccttcgaggtgtgtCgttccatgctggcctccctg	3	11	13	14	3	0	0	0	0	0	0	4	1	2	0	5	3	2	2	5	3	0	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr22:50961569C>A	uc003blr.3	+	19	1773	c.1651C>A	c.(1651-1653)CGT>AGT	p.R551S	NCAPH2_uc003blv.2_Missense_Mutation_p.R551S|NCAPH2_uc010hbb.2_Intron|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Missense_Mutation_p.R552S|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	551					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CGAGGTGTGTCGTTCCATGCT	0.647													11	35					5.50884e-06	5.86811e-06	1	0	A	50961569	A	A	50961569	3	1	34	1	0	0	0	0	1	0	0	0	10264	884	31	3	1767	3	NCAPH2	22	50961569	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	900	50961569	342997	404	6696			2	8		7	7	7058	C		1.162083e-09
NCAPH2	29781	broad.mit.edu	37	chr22	50961585	50961585	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgtcgttccatgctggcctCcctgcagctggtgagtagcc	4	11	13	13	1	0	1	0	1	0	0	3	1	2	1	4	2	4	5	4	2	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr22:50961585C>T	uc003blr.3	+	19	1789	c.1667C>T	c.(1666-1668)TCC>TTC	p.S556F	NCAPH2_uc003blv.2_Missense_Mutation_p.S556F|NCAPH2_uc010hbb.2_Intron|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Missense_Mutation_p.S557F|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	556					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		ATGCTGGCCTCCCTGCAGCTG	0.637													14	36					0	0	0	0	T	50961585	T	T	50961585	3	4	34	1	0	0	0	0	1	0	0	0	10264	855	30	2	1783	2	NCAPH2	22	50961585	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	16	50961585	342981	405	6697			2	8		7	7	7058	C		1.162083e-09
SCO2	9997	broad.mit.edu	37	chr22	50962141	50962141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaatccgtgaagaggccgtCagggttgagcaggtagatgg	10	8	17	6	2	1	4	1	2	0	2	2	4	2	4	2	4	1	4	2	4	3	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr22:50962141C>T	uc003bma.2	-	2	876	c.700G>A	c.(700-702)GAC>AAC	p.D234N	SCO2_uc003blz.3_Missense_Mutation_p.D234N	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	234	Thioredoxin.				cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AAGAGGCCGTCAGGGTTGAGC	0.582													42	170					0	0	0	0	T	50962141	T	T	50962141	3	4	34	1	0	0	0	0	1	0	0	0	13997	826	29	2	104	2	SCO2	22	50962141	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	556	50962141	342425	406	6698			2	8		7	7	7058	C		1.162083e-09
SCO2	9997	broad.mit.edu	37	chr22	50962592	50962592	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcttttgctgctgcagcctCtccttctcagccctcagggc	3	12	9	17	1	3	0	2	0	2	0	5	0	3	0	3	1	5	4	3	1	0	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr22:50962592C>G	uc003bma.2	-	2	425	c.249G>C	c.(247-249)GAG>GAC	p.E83D	SCO2_uc003blz.3_Missense_Mutation_p.E83D	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	83					cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCTGCAGCCTCTCCTTCTCAG	0.687													20	62					0	0	0	0	G	50962592	G	G	50962592	3	3	34	1	0	0	0	0	1	0	0	0	13997	912	32	2	555	2	SCO2	22	50962592	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	451	50962592	341974	407	6699			2	8		7	7	7058	C		1.162083e-09
SCO2	9997	broad.mit.edu	37	chr22	50962711	50962711	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccctgcccacctgtctctgCagggccctgccttgacaaaa	7	8	9	17	0	1	1	0	1	1	0	2	1	1	1	5	1	3	1	5	1	2	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr22:50962711C>T	uc003bma.2	-	2	306	c.130G>A	c.(130-132)GCA>ACA	p.A44T	SCO2_uc003blz.3_Missense_Mutation_p.A44T	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	44					cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCTGTCTCTGCAGGGCCCTGC	0.687													22	37					0	0	0	0	T	50962711	T	T	50962711	3	4	34	1	0	0	0	0	1	0	0	0	13997	710	25	4	674	4	SCO2	22	50962711	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	119	50962711	341855	408	6700			2	8		7	7	7058	C		1.162083e-09
TYMP	1890	broad.mit.edu	37	chr22	50967726	50967726	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggtcagcaccgaggtctcctCcagatccatgccccgaagtc	8	7	10	16	2	2	1	1	0	1	1	6	3	4	1	6	2	2	1	6	2	1	0			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chr22:50967726C>G	uc003bmb.3	-	2	376	c.256G>C	c.(256-258)GAG>CAG	p.E86Q	TYMP_uc003bmc.3_Missense_Mutation_p.E86Q|TYMP_uc003bmd.3_Missense_Mutation_p.E86Q|TYMP_uc010hbd.2_Missense_Mutation_p.E86Q|TYMP_uc003bme.3_Missense_Mutation_p.E86Q|TYMP_uc003bmf.3_Missense_Mutation_p.E86Q|TYMP_uc011arz.1_Missense_Mutation_p.E86Q	NM_001113756	NP_001107228	P19971	TYPH_HUMAN	endothelial cell growth factor 1	86					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			ovary(1)	1		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	GAGGTCTCCTCCAGATCCATG	0.677													10	47					0	0	0	0	G	50967726	G	G	50967726	3	3	34	1	0	0	0	0	1	0	0	0	16879	864	30	2	1224	2	TYMP	22	50967726	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	5015	50967726	336840	409	6701			2	8		7	7	7058	C		1.162083e-09
SFRS17A	8227	broad.mit.edu	37	chrX	1712358	1712358	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccaaggtcccggaggctatGgcagcggctaccatcgtgca	8	6	13	14	3	0	0	0	0	0	0	2	1	1	1	3	5	3	4	3	5	3	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:1712358G>T	uc004cqa.2	+	2	199	c.3G>T	c.(1-3)ATG>ATT	p.M1I	SFRS17A_uc010ncx.1_Missense_Mutation_p.M1I|SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_5'Flank	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	1					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGGAGGCTATGGCAGCGGCTA	0.627													42	136					1.57019e-19	1.99325e-19	1	0	T	1712358	T	T	1712358	3	4	34	1	0	0	0	0	1	0	0	0	14238	1348	47	4	5	4	SFRS17A	23	1712358	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08		1712358	153558202	410	6702											
FRMPD4	9758	broad.mit.edu	37	chrX	12736225	12736225	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaaggacagtcaaagatggTatgtggccactgaaggtggg	12	7	16	6	0	1	2	1	1	0	1	1	3	1	3	1	5	0	2	1	5	4	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:12736225T>C	uc004cuz.1	+	16	3786	c.3280T>C	c.(3280-3282)TAT>CAT	p.Y1094H	FRMPD4_uc011mij.1_Missense_Mutation_p.Y1086H	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1094					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TCAAAGATGGTATGTGGCCAC	0.493													35	66					0	0	0	0	C	12736225	C	C	12736225	3	2	34	1	0	0	0	0	1	0	0	0	6093	1638	57	5	3342	5	FRMPD4	23	12736225	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	11023867	12736225	142534335	411	6703											
RBBP7	5931	broad.mit.edu	37	chrX	16881168	16881168	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccagatgattctgctcatCagacgtatgagtccccagca	11	9	8	13	1	3	4	2	2	1	2	4	4	4	4	3	0	2	3	3	0	1	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:16881168C>G	uc004cxt.2	-	3	575	c.217G>C	c.(217-219)GAT>CAT	p.D73H	RBBP7_uc004cxs.1_Missense_Mutation_p.D117H|RBBP7_uc004cxu.2_Missense_Mutation_p.D73H	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	73	WD 1.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					TTCTGCTCATCAGACGTATGA	0.418													49	75					0	0	0	0	G	16881168	G	G	16881168	3	3	34	1	0	0	0	0	1	0	0	0	13169	826	29	2	1100	2	RBBP7	23	16881168	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	4144943	16881168	138389392	412	6704											
PHEX	5251	broad.mit.edu	37	chrX	22132680	22132680	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagatgtttgtagatgtgtaCttccaggaagataagaagga	15	11	12	3	0	0	4	0	0	0	4	1	6	1	6	1	2	1	3	1	2	6	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:22132680C>G	uc004dah.2	+	11	1481	c.1278C>G	c.(1276-1278)TAC>TAG	p.Y426*	PHEX_uc011mjr.1_Nonsense_Mutation_p.Y426*|PHEX_uc011mjs.1_Nonsense_Mutation_p.Y329*	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	426	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						TAGATGTGTACTTCCAGGAAG	0.413													25	46					0	0	0	0	G	22132680	G	G	22132680	4	3	34	1	0	0	0	0	0	1	0	0	11874	576	20	4	1320	4	PHEX	23	22132680	Nonsense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	5251512	22132680	133137880	413	6705											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29973758	29973758	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtacctcctaccggcaccCtgcctcttacctccataggc	7	9	6	19	2	1	0	0	0	1	0	3	0	3	0	7	2	4	2	7	2	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:29973758C>A	uc004dby.2	+	11	2420	c.1912C>A	c.(1912-1914)CTG>ATG	p.L638M		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	638	Cytoplasmic (Potential).|Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TACCGGCACCCTGCCTCTTAC	0.502													13	18					3.45872e-05	3.66041e-05	1	0	A	29973758	A	A	29973758	3	1	34	1	0	0	0	0	1	0	0	0	7700	680	24	4	1950	4	IL1RAPL1	23	29973758	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	7841078	29973758	125296802	414	6706											
CXorf59	286464	broad.mit.edu	37	chrX	36162888	36162888	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctttctccctttggagcAggatgcatttttttctcctt	4	20	6	11	0	3	0	0	0	3	0	6	2	3	2	2	2	2	2	2	2	0	6			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:36162888A>T	uc004ddk.1	+	11	1657	c.1471A>T	c.(1471-1473)AGG>TGG	p.R491W		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	491						integral to membrane				central_nervous_system(1)	1						cctttggagcaggatgcattt	0													4	6					0	0	0	0	T	36162888	T	T	36162888	3	4	34	1	0	0	0	0	1	0	0	0	4132	179	7	5	1509	5	CXorf59	23	36162888	Missense_Mutation	SNP	A	TCGA-BB-7871-01A-11D-2229-08	6189130	36162888	119107672	415	6707											
HEPH	9843	broad.mit.edu	37	chrX	65417622	65417622	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccactgctcaggatcctgcTtgtctcacttggatgtactt	6	14	8	13	0	2	0	2	0	1	0	4	2	3	2	2	2	3	3	2	2	1	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:65417622T>A	uc011moz.1	+	10	1668	c.1608T>A	c.(1606-1608)GCT>GCA	p.A536A	HEPH_uc004dwn.2_Silent_p.A536A|HEPH_uc004dwo.2_Silent_p.A266A|HEPH_uc010nkr.2_Intron|HEPH_uc011mpa.1_Silent_p.A536A	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	533	Extracellular (Potential).|Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						AGGATCCTGCTTGTCTCACTT	0.572													19	71					0	0	0	0	A	65417622	A	A	65417622	2	1	34	1	0	0	0	0	0	0	0	1	7093	1596	56	5		5	HEPH	23	65417622	Silent	SNP	T	TCGA-BB-7871-01A-11D-2229-08	29254734	65417622	89852938	416	6708											
EFNB1	1947	broad.mit.edu	37	chrX	68058522	68058523	+	Frame_Shift_Ins	INS	-	C	C																															gacaagctggacatcatctgINScccccgagcagaagcagggc																								rs148907346		TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:68058522_68058523insC	uc004dxd.3	+	2	971_972	c.191_192insC	c.(190-192)TGCfs	p.C64fs	EFNB1_uc004dxe.2_Frame_Shift_Ins_p.C64fs	NM_004429	NP_004420	P98172	EFNB1_HUMAN	ephrin-B1 precursor	64	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding				0						GACATCATCTGCCCCCGAGCAG	0.574													---	---	---								C	68058523	C	C	68058522	7	5	34	1	0	1	1	0	0	0	0	0	4977	1319	46	0	197	0	EFNB1	23	68058522	Frame_Shift_Ins	INS	-	TCGA-BB-7871-01A-11D-2229-08	2640900	68058522	87212038	417	6709											
MED12	9968	broad.mit.edu	37	chrX	70342150	70342150	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccacttgcctattgcccCgtccaacctgcccatgccag	7	9	7	18	1	0	1	0	1	0	0	1	1	1	1	8	0	5	0	8	0	2	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:70342150C>G	uc004dyy.2	+	8	1401	c.1202C>G	c.(1201-1203)CCG>CGG	p.P401R	MED12_uc011mpq.1_Missense_Mutation_p.P401R|MED12_uc004dyz.2_Missense_Mutation_p.P401R|MED12_uc004dza.2_Missense_Mutation_p.P248R	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	401					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CCTATTGCCCCGTCCAACCTG	0.522													47	95					0	0	0	0	G	70342150	G	G	70342150	3	3	34	1	0	0	0	0	1	0	0	0	9481	652	23	3	1232	3	MED12	23	70342150	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2283628	70342150	84928410	418	6710											
MED12	9968	broad.mit.edu	37	chrX	70357671	70357671	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactccagccagccttaccaGagcacccacccttctaccaa	11	7	4	19	0	1	1	0	0	1	1	2	1	2	1	7	0	6	1	7	0	4	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:70357671G>T	uc004dyy.2	+	41	6121	c.5922G>T	c.(5920-5922)CAG>CAT	p.Q1974H	MED12_uc011mpq.1_Intron|MED12_uc004dyz.2_Missense_Mutation_p.Q1973H|MED12_uc004dza.2_Missense_Mutation_p.Q1824H|MED12_uc010nla.2_Missense_Mutation_p.Q603H	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1974	Gln-rich.|Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					AGCCTTACCAGAGCACCCACC	0.582													50	94					1.21353e-23	1.60711e-23	1	0	T	70357671	T	T	70357671	3	4	34	1	0	0	0	0	1	0	0	0	9481	933	33	2	6084	2	MED12	23	70357671	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	15521	70357671	84912889	419	6711											
RLIM	51132	broad.mit.edu	37	chrX	73811417	73811417	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacgaagtttgttgccttctGtatattctgtaatgcaaaca	11	16	7	7	1	2	0	0	0	2	0	2	1	2	0	1	0	4	5	1	0	6	8			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:73811417G>A	uc004ebu.2	-	5	2023	c.1733C>T	c.(1732-1734)ACA>ATA	p.T578I	RLIM_uc004ebw.2_Missense_Mutation_p.T578I	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	578	RING-type.				random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GTTGCCTTCTGTATATTCTGT	0.408													26	75					0	0	0	0	A	73811417	A	A	73811417	3	1	34	1	0	0	0	0	1	0	0	0	13455	1377	48	4	145	4	RLIM	23	73811417	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	3453746	73811417	81459143	420	6712											
ATRX	546	broad.mit.edu	37	chrX	76778862	76778862	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctttatgtatctgaaggagCtctgcaagtatggtatcctg	9	15	10	7	0	3	1	0	1	3	0	4	2	4	2	1	2	2	5	1	2	6	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:76778862C>A	uc004ecp.3	-	31	6949	c.6717G>T	c.(6715-6717)GAG>GAT	p.E2239D	ATRX_uc004ecq.3_Missense_Mutation_p.E2201D|ATRX_uc004eco.3_Missense_Mutation_p.E2024D	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2239					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCTGAAGGAGCTCTGCAAGTA	0.368			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						30	72					4.3181e-19	5.46736e-19	1	0	A	76778862	A	A	76778862	3	1	34	1	0	0	0	0	1	0	0	0	1210	796	28	4	781	4	ATRX	23	76778862	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	2967445	76778862	78491698	421	6713											
BRWD3	254065	broad.mit.edu	37	chrX	79990691	79990691	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcagtaaatttcaccgggCgatctctaaagataaaaata	16	11	6	8	2	3	1	2	0	2	1	5	2	3	1	1	1	0	1	1	1	8	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:79990691C>G	uc004edt.2	-	10	1183	c.920G>C	c.(919-921)CGC>CCC	p.R307P	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_Missense_Mutation_p.R136P|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_5'UTR|BRWD3_uc004edr.2_5'UTR|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_5'UTR|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_5'UTR|BRWD3_uc004eea.2_5'UTR|BRWD3_uc004eeb.2_5'UTR	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	307										ovary(4)	4						TTTCACCGGGCGATCTCTAAA	0.388													17	44					0	0	0	0	G	79990691	G	G	79990691	3	3	34	1	0	0	0	0	1	0	0	0	1531	768	27	3	4616	3	BRWD3	23	79990691	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	3211829	79990691	75279869	422	6714											
BRWD3	254065	broad.mit.edu	37	chrX	79999663	79999663	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcatagttaacagccatGtcagaaatttcagcagagtg	13	13	8	7	0	3	2	3	0	0	2	3	2	3	2	1	0	3	2	1	0	3	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:79999663G>T	uc004edt.2	-	8	944	c.681C>A	c.(679-681)GAC>GAA	p.D227E	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_Missense_Mutation_p.D56E|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_5'UTR|BRWD3_uc004edr.2_5'UTR|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_5'UTR|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_5'UTR|BRWD3_uc004eea.2_5'UTR|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	227	WD 3.									ovary(4)	4						TAACAGCCATGTCAGAAATTT	0.433													32	81					1.22384e-17	1.5259e-17	1	0	T	79999663	T	T	79999663	3	4	34	1	0	0	0	0	1	0	0	0	1531	1368	48	4	4863	4	BRWD3	23	79999663	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	8972	79999663	75270897	423	6715											
PCDH11X	27328	broad.mit.edu	37	chrX	91132397	91132397	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgctctcataactgtgacGgataaggatgcggaccataa	13	10	10	8	2	1	1	1	1	1	0	2	4	1	4	1	3	3	1	1	3	3	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:91132397G>C	uc004efk.1	+	2	2003	c.1158G>C	c.(1156-1158)ACG>ACC	p.T386T	PCDH11X_uc004efl.1_Silent_p.T386T|PCDH11X_uc004efo.1_Silent_p.T386T|PCDH11X_uc010nmv.1_Silent_p.T386T|PCDH11X_uc004efm.1_Silent_p.T386T|PCDH11X_uc004efn.1_Silent_p.T386T|PCDH11X_uc004efh.1_Silent_p.T386T|PCDH11X_uc004efj.1_Silent_p.T386T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	386	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TAACTGTGACGGATAAGGATG	0.413													28	52					0	0	0	0	C	91132397	C	C	91132397	2	2	34	1	0	0	0	0	0	0	0	1	11562	1103	39	3		3	PCDH11X	23	91132397	Silent	SNP	G	TCGA-BB-7871-01A-11D-2229-08	11132734	91132397	64138163	424	6716											
ARMCX5	64860	broad.mit.edu	37	chrX	101858708	101858708	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagcacagtgatcccgaaGtgagagataaagtcatacga	16	6	11	8	2	1	4	1	2	0	2	2	7	2	4	1	0	2	1	1	0	4	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:101858708G>T	uc004ejg.2	+	6	2520	c.1639G>T	c.(1639-1641)GTG>TTG	p.V547L	ARMCX5_uc004ejh.2_Missense_Mutation_p.V547L	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	547							binding			ovary(1)	1						TGATCCCGAAGTGAGAGATAA	0.378													36	73					4.32679e-17	5.38104e-17	1	0	T	101858708	T	T	101858708	3	4	34	1	0	0	0	0	1	0	0	0	964	1029	36	4	1641	4	ARMCX5	23	101858708	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	10726311	101858708	53411852	425	6717											
CXorf56	63932	broad.mit.edu	37	chrX	118675341	118675341	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgcgctccagctgtttttCaatcactttggcattctgtg	5	18	8	10	1	3	0	2	0	1	0	4	0	4	0	1	1	2	4	1	1	1	5			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:118675341C>G	uc004erk.1	-	6	602	c.556G>C	c.(556-558)GAA>CAA	p.E186Q	uc004eri.2_5'Flank|CXorf56_uc004erj.1_Missense_Mutation_p.E137Q|CXorf56_uc011mtu.1_Missense_Mutation_p.E172Q	NM_022101	NP_071384	Q9H5V9	CX056_HUMAN	hypothetical protein LOC63932	186	Potential.						protein binding				0						AGCTGTTTTTCAATCACTTTG	0.483													49	80					0	0	0	0	G	118675341	G	G	118675341	3	3	34	1	0	0	0	0	1	0	0	0	4129	835	29	2	120	2	CXorf56	23	118675341	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	16816633	118675341	36595219	426	6718											
GPC4	2239	broad.mit.edu	37	chrX	132436980	132436980	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaggacggacaccagcaCtgtcggctttctcattggca	8	8	10	15	2	1	0	1	0	1	0	3	2	1	2	3	4	1	3	3	4	0	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:132436980C>A	uc004exc.1	-	9	1798	c.1586G>T	c.(1585-1587)AGT>ATT	p.S529I	GPC4_uc011mvg.1_Missense_Mutation_p.S459I	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	529					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					GACACCAGCACTGTCGGCTTT	0.517													119	211					6.47804e-62	9.17411e-62	1	0	A	132436980	A	A	132436980	3	1	34	1	0	0	0	0	1	0	0	0	6638	565	20	4	88	4	GPC4	23	132436980	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	13761639	132436980	22833580	427	6719											
MCF2	4168	broad.mit.edu	37	chrX	138714492	138714492	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catttaaataatatactcttActggtaatttaagcataaaa	18	15	3	5	0	1	0	0	0	1	0	1	0	1	0	0	1	3	2	0	1	10	10			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:138714492A>T	uc004fau.2	-	2	465	c.171_splice	c.e2+1	p.P57_splice	MCF2_uc004fav.2_Splice_Site_p.P57_splice|MCF2_uc011mwl.1_Splice_Site_p.P57_splice|MCF2_uc010nsh.1_Splice_Site_p.P57_splice|MCF2_uc011mwm.1_Splice_Site_p.P57_splice|MCF2_uc011mwn.1_Splice_Site_p.P202_splice|MCF2_uc004faw.2_Splice_Site_p.P117_splice|MCF2_uc011mwo.1_Splice_Site_p.P117_splice	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					ATATACTCTTACTGGTAATTT	0.338													24	40					0	0	0	0	T	138714492	T	T	138714492	5	4	34	1	0	0	0	0	0	0	1	0	9431	405	14	5	2780	5	MCF2	23	138714492	Splice_Site	SNP	A	TCGA-BB-7871-01A-11D-2229-08	6277512	138714492	16556068	428	6720											
MAGEC1	9947	broad.mit.edu	37	chrX	140994994	140994994	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttcctcagagccctcctcagGgggaggactccatgtctcct	6	10	10	15	0	3	1	2	0	1	1	7	3	6	3	5	3	1	0	5	3	0	1			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:140994994G>A	uc004fbt.2	+	4	2090	c.1804G>A	c.(1804-1806)GGG>AGG	p.G602R	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	602							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTCCTCAGGGGGAGGACTC	0.582										HNSCC(15;0.026)			135	249					0	0	0	0	A	140994994	A	A	140994994	3	1	34	1	0	0	0	0	1	0	0	0	9233	1232	43	4	1810	4	MAGEC1	23	140994994	Missense_Mutation	SNP	G	TCGA-BB-7871-01A-11D-2229-08	2280502	140994994	14275566	429	6721											
MAGEC1	9947	broad.mit.edu	37	chrX	140995039	140995039	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actttcctcagagtcctcttCagggggaggaattccagtct	8	12	10	11	0	4	1	2	0	2	1	7	3	7	3	3	3	0	0	3	3	1	3			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:140995039C>G	uc004fbt.2	+	4	2135	c.1849C>G	c.(1849-1851)CAG>GAG	p.Q617E	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	617							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTCCTCTTCAGGGGGAGGA	0.572										HNSCC(15;0.026)			106	187					0	0	0	0	G	140995039	G	G	140995039	3	3	34	1	0	0	0	0	1	0	0	0	9233	827	29	2	1855	2	MAGEC1	23	140995039	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	45	140995039	14275521	430	6722											
SLITRK2	84631	broad.mit.edu	37	chrX	144905688	144905688	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctatctgtccagacagccCaaacttgtcagatggaaccg	11	8	10	12	1	2	2	1	0	1	2	3	3	3	3	3	2	3	1	3	2	3	2			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:144905688C>G	uc004fcd.2	+	5	2735	c.1745C>G	c.(1744-1746)CCA>CGA	p.P582R	SLITRK2_uc010nsp.2_Missense_Mutation_p.P582R|SLITRK2_uc010nso.2_Missense_Mutation_p.P582R|SLITRK2_uc011mwq.1_Missense_Mutation_p.P582R|SLITRK2_uc011mwr.1_Missense_Mutation_p.P582R|SLITRK2_uc011mws.1_Missense_Mutation_p.P582R|SLITRK2_uc004fcg.2_Missense_Mutation_p.P582R|SLITRK2_uc011mwt.1_Missense_Mutation_p.P582R	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	582	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGACAGCCCAAACTTGTCA	0.473													24	31					0	0	0	0	G	144905688	G	G	144905688	3	3	34	1	0	0	0	0	1	0	0	0	14807	594	21	4	1747	4	SLITRK2	23	144905688	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	3910649	144905688	10364872	431	6723											
ARHGAP4	393	broad.mit.edu	37	chrX	153174934	153174934	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccaggaggccctcgggacTgctcccagactcccctgcag	6	6	12	17	1	0	1	0	0	0	1	3	3	2	3	5	3	3	2	5	3	0	0	rs145982906	byFrequency	TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:153174934T>G	uc004fjk.1	-	20	2512	c.2470A>C	c.(2470-2472)AGT>CGT	p.S824R	ARHGAP4_uc004fjj.1_Missense_Mutation_p.S175R|ARHGAP4_uc011mzf.1_Missense_Mutation_p.S801R|ARHGAP4_uc004fjl.1_Missense_Mutation_p.S864R|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	824					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCTCGGGACTGCTCCCAGAC	0.672													11	50					0	0	0	0	G	153174934	G	G	153174934	3	3	34	1	0	0	0	0	1	0	0	0	885	1580	55	5	382	5	ARHGAP4	23	153174934	Missense_Mutation	SNP	T	TCGA-BB-7871-01A-11D-2229-08	8269246	153174934	2095626	432	6724											
F8	2157	broad.mit.edu	37	chrX	154225261	154225261	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tactcaccctcagaagctttCcagtaggatacaccaacagc	13	8	6	14	0	2	1	2	0	0	1	3	2	3	2	3	1	5	2	3	1	5	4			TCGA-BB-7871-01A-11D-2229-08	TCGA-BB-7871-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	8e13f8a5-5d80-4e34-bffa-54ae808114e7	28a3eef0-d823-4a45-a686-4f8abb8e2647	g.chrX:154225261C>G	uc004fmt.2	-	3	546	c.375G>C	c.(373-375)TGG>TGC	p.W125C	F8_uc011mzx.1_Missense_Mutation_p.W90C	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	125	Plastocyanin-like 1.|F5/8 type A 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CAGAAGCTTTCCAGTAGGATA	0.438													72	132					0	0	0	0	G	154225261	G	G	154225261	3	3	34	1	0	0	0	0	1	0	0	0	5375	856	30	2	6804	2	F8	23	154225261	Missense_Mutation	SNP	C	TCGA-BB-7871-01A-11D-2229-08	1050327	154225261	1045299	433	6725											
UBR4	23352	broad.mit.edu	37	chr1	19439351	19439351	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaacaactctttgcgcgaaGcaaagactttctaagaacaa	16	8	6	11	2	2	2	0	0	2	2	2	3	2	2	1	0	5	1	1	0	7	3			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:19439351G>T	uc001bbi.2	-	78	11472	c.11468C>A	c.(11467-11469)GCT>GAT	p.A3823D	UBR4_uc001bbj.1_3'UTR	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3823					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TTTGCGCGAAGCAAAGACTTT	0.398													69	176					4.67498e-28	5.2286e-28	1	0	T	19439351	T	T	19439351	3	4	35	1	0	0	0	0	1	0	0	0	16972	971	34	4	4199	4	UBR4	1	19439351	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08		19439351	229811270	1	6726											
AGL	178	broad.mit.edu	37	chr1	100349945	100349945	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagttgccacaaaagggccCaatgaatatattcaagaaat	17	8	9	7	0	1	2	1	1	0	1	1	3	1	3	2	2	1	1	2	2	8	4			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:100349945C>T	uc001dsi.1	+	19	2884	c.2484C>T	c.(2482-2484)CCC>CCT	p.P828P	AGL_uc001dsj.1_Silent_p.P828P|AGL_uc001dsk.1_Silent_p.P828P|AGL_uc001dsl.1_Silent_p.P828P|AGL_uc001dsm.1_Silent_p.P812P|AGL_uc001dsn.1_Silent_p.P811P	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	828	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CAAAAGGGCCCAATGAATATA	0.289													11	41					0	0	0	0	T	100349945	T	T	100349945	2	4	35	1	0	0	0	0	0	0	0	1	384	581	21	4		4	AGL	1	100349945	Silent	SNP	C	TCGA-BB-7872-01A-11D-2229-08	80910594	100349945	148900676	2	6727											
RPRD2	23248	broad.mit.edu	37	chr1	150337289	150337289	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggatcgaaaattccagtcGgtaaccaacaccatggagtc	13	9	9	10	2	0	0	0	0	0	0	4	3	1	2	3	3	2	1	3	3	4	3	rs72696841	by1000genomes	TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:150337289G>T	uc009wlr.2	+	1	300	c.99G>T	c.(97-99)TCG>TCT	p.S33S	RPRD2_uc010pcc.1_Silent_p.S33S|RPRD2_uc001eup.3_Silent_p.S33S	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	33	CID.						protein binding			ovary(1)	1						AATTCCAGTCGGTAACCAACA	0.552													6	25					0.000157383	0.000165155	1	0	T	150337289	T	T	150337289	2	4	35	1	0	0	0	0	0	0	0	1	13682	1103	39	3		3	RPRD2	1	150337289	Silent	SNP	G	TCGA-BB-7872-01A-11D-2229-08	49987344	150337289	98913332	3	6728											
POU2F1	5451	broad.mit.edu	37	chr1	167385013	167385013	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcctctgccagcggggctgCgtccaccaccaccaccgcct	5	5	11	20	3	1	0	0	0	1	0	2	0	2	0	8	3	3	1	8	3	0	0			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:167385013C>T	uc001gec.2	+	17	2360	c.2198C>T	c.(2197-2199)GCG>GTG	p.A733V	POU2F1_uc001ged.2_Missense_Mutation_p.A731V|POU2F1_uc001gee.2_Missense_Mutation_p.A733V|POU2F1_uc010plh.1_Missense_Mutation_p.A670V|POU2F1_uc001gef.2_Missense_Mutation_p.A745V|POU2F1_uc001geg.2_Intron	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	733					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						AGCGGGGCTGCGTCCACCACC	0.617													62	312					0	0	0	0	T	167385013	T	T	167385013	3	4	35	1	0	0	0	0	1	0	0	0	12326	768	27	1	2256	1	POU2F1	1	167385013	Missense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08	17047724	167385013	81865608	4	6729											
CRB1	23418	broad.mit.edu	37	chr1	197390841	197390841	+	Frame_Shift_Del	DEL	T	-	-																															cagcaatggtgttgctctgcTtaacttctataatatgccat																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:197390841delT	uc001gtz.2	+	6	2018	c.1883delT	c.(1882-1884)CTTfs	p.L628fs	CRB1_uc010poz.1_Frame_Shift_Del_p.L559fs|CRB1_uc010ppa.1_Intron|CRB1_uc009wza.2_Frame_Shift_Del_p.L516fs|CRB1_uc010ppb.1_Frame_Shift_Del_p.L628fs|CRB1_uc010ppc.1_Intron|CRB1_uc010ppd.1_Frame_Shift_Del_p.L109fs|CRB1_uc001gub.1_Frame_Shift_Del_p.L277fs	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	628	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GTTGCTCTGCTTAACTTCTAT	0.428													---	---	---								-	197390841	-	-	197390841	7	5	35	1	0	1	0	1	0	0	0	0	3863	1609	56	0	1905	0	CRB1	1	197390841	Frame_Shift_Del	DEL	T	TCGA-BB-7872-01A-11D-2229-08	30005828	197390841	51859780	5	6730											
MFSD4	148808	broad.mit.edu	37	chr1	205566948	205566948	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacaggggcaggagttggCgagatggtgctgcagatgct	8	8	19	6	1	0	3	0	1	0	2	0	5	0	4	0	5	3	5	0	5	0	1			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:205566948C>T	uc001hcv.3	+	8	1424	c.1338C>T	c.(1336-1338)GGC>GGT	p.G446G	MFSD4_uc010prk.1_Silent_p.G359G|MFSD4_uc010prl.1_Intron|MFSD4_uc010prm.1_Silent_p.G391G|MFSD4_uc009xbn.2_RNA	NM_181644	NP_857595	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing	446	Helical; (Potential).				transmembrane transport	integral to membrane				skin(2)|central_nervous_system(1)	3	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CAGGAGTTGGCGAGATGGTGC	0.522													36	178					0	0	0	0	T	205566948	T	T	205566948	2	4	35	1	0	0	0	0	0	0	0	1	9586	755	27	1		1	MFSD4	1	205566948	Silent	SNP	C	TCGA-BB-7872-01A-11D-2229-08	8176107	205566948	43683673	6	6731											
CD34	947	broad.mit.edu	37	chr1	208073192	208073192	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgtttgttgtggcctcattgCcatgttgagacacagggtgc	6	14	13	8	0	1	1	1	1	0	1	1	2	1	1	2	2	2	3	2	2	0	4			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:208073192C>A	uc001hgw.1	-	2	494	c.236G>T	c.(235-237)GGC>GTC	p.G79V	CD34_uc001hgx.1_Missense_Mutation_p.G79V|CD34_uc010psj.1_Missense_Mutation_p.A29S	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	79	Extracellular (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						GGCCTCATTGCCATGTTGAGA	0.438													31	126					2.32173e-10	2.49807e-10	1	0	A	208073192	A	A	208073192	3	1	35	1	0	0	0	0	1	0	0	0	3021	739	26	4	968	4	CD34	1	208073192	Missense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08	2506244	208073192	41177429	7	6732											
HLX	3142	broad.mit.edu	37	chr1	221053233	221053233	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctggctcccttctacgccTccaacttcagcctctggtcg	4	11	9	17	2	3	0	1	0	2	0	6	0	5	0	4	3	3	2	4	3	2	3			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:221053233T>A	uc001hmv.3	+	1	491	c.34T>A	c.(34-36)TCC>ACC	p.S12T		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	12					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		CTTCTACGCCTCCAACTTCAG	0.721													7	14					0	0	0	0	A	221053233	A	A	221053233	3	1	35	1	0	0	0	0	1	0	0	0	7255	1551	54	5	36	5	HLX	1	221053233	Missense_Mutation	SNP	T	TCGA-BB-7872-01A-11D-2229-08	12980041	221053233	28197388	8	6733											
RGS7	6000	broad.mit.edu	37	chr1	241031928	241031929	+	Frame_Shift_Ins	INS	-	A	A																															aacgctctctcttggctgtcINSaaggatcttcctttcaatct																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:241031928_241031929insA	uc001hyv.2	-	9	897_898	c.567_568insT	c.(565-570)CTTGACfs	p.L189fs	RGS7_uc010pyh.1_Frame_Shift_Ins_p.L163fs|RGS7_uc010pyj.1_Frame_Shift_Ins_p.L105fs|RGS7_uc001hyu.2_Frame_Shift_Ins_p.L189fs|RGS7_uc009xgn.1_Frame_Shift_Ins_p.L136fs|RGS7_uc001hyw.2_Frame_Shift_Ins_p.L189fs|RGS7_uc001hyt.2_Frame_Shift_Ins_p.L21fs	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	189_190					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCTTGGCTGTCAAGGATCTTCC	0.465													---	---	---								A	241031929	A	A	241031928	7	5	35	1	0	1	1	0	0	0	0	0	13375	826	29	0	935	0	RGS7	1	241031928	Frame_Shift_Ins	INS	-	TCGA-BB-7872-01A-11D-2229-08	19978695	241031928	8218693	9	6734											
PLD5	200150	broad.mit.edu	37	chr1	242277314	242277314	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctgtttttagggcaaaaGagttttggagaattctgtga	10	16	11	4	0	2	3	0	1	2	2	2	4	2	3	0	2	0	3	0	2	4	7			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:242277314G>C	uc001hzn.1	-	7	1075	c.948C>G	c.(946-948)CTC>CTG	p.L316L	PLD5_uc001hzl.3_Silent_p.L254L|PLD5_uc001hzm.3_Silent_p.L106L|PLD5_uc001hzo.1_Silent_p.L224L			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	316						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TAGGGCAAAAGAGTTTTGGAG	0.403													14	70					0	0	0	0	C	242277314	C	C	242277314	2	2	35	1	0	0	0	0	0	0	0	1	12104	929	33	2		2	PLD5	1	242277314	Silent	SNP	G	TCGA-BB-7872-01A-11D-2229-08	1245386	242277314	6973307	10	6735											
OR2M2	391194	broad.mit.edu	37	chr1	248343571	248343571	+	Frame_Shift_Del	DEL	C	-	-																															cagcaagtccatttctatggCtggttgtgtcacacaaattt																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:248343571delC	uc010pzf.1	+	1	284	c.284delC	c.(283-285)GCTfs	p.A95fs		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATTTCTATGGCTGGTTGTGTC	0.463													---	---	---								-	248343571	-	-	248343571	7	5	35	1	0	1	0	1	0	0	0	0	11064	797	28	0	286	0	OR2M2	1	248343571	Frame_Shift_Del	DEL	C	TCGA-BB-7872-01A-11D-2229-08	6066257	248343571	907050	11	6736											
OR2M3	127062	broad.mit.edu	37	chr1	248367188	248367188	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccccaacacaggacaagatGgtgtctgtattctacaccat	12	10	7	12	0	2	1	0	0	2	1	3	2	3	2	3	2	2	1	3	2	4	3			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr1:248367188G>T	uc010pzg.1	+	1	819	c.819G>T	c.(817-819)ATG>ATT	p.M273I		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGGACAAGATGGTGTCTGTAT	0.493													37	168					2.48057e-37	2.81131e-37	1	0	T	248367188	T	T	248367188	3	4	35	1	0	0	0	0	1	0	0	0	11065	1348	47	4	821	4	OR2M3	1	248367188	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	23617	248367188	883433	12	6737											
MAP4K3	8491	broad.mit.edu	37	chr2	39499427	39499427	+	Frame_Shift_Del	DEL	G	-	-																															taaggatgtacccttaccttGgcagtattctgtcagggagt																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr2:39499427delG	uc002rro.2	-	26	2061	c.1970delC	c.(1969-1971)CCAfs	p.P657fs	MAP4K3_uc002rrp.2_Frame_Shift_Del_p.P636fs|MAP4K3_uc010yns.1_Frame_Shift_Del_p.P210fs	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	657	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				CCCTTACCTTGGCAGTATTCT	0.358													---	---	---								-	39499427	-	-	39499427	7	5	35	1	0	1	0	1	0	0	0	0	9314	1348	47	0	750	0	MAP4K3	2	39499427	Frame_Shift_Del	DEL	G	TCGA-BB-7872-01A-11D-2229-08		39499427	203699946	13	6738											
RGPD5	84220	broad.mit.edu	37	chr2	113191010	113191010	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggcgacgtaccgctccacAtcggccttgctgcgcctcat	6	8	11	16	5	1	0	1	0	0	0	3	2	2	0	4	2	3	3	4	2	1	2	rs13021601		TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr2:113191010A>C	uc002ths.1	-	1	98	c.21T>G	c.(19-21)GAT>GAG	p.D7E	RGPD8_uc010fkk.1_Intron|RGPD5_uc010yxm.1_Missense_Mutation_p.D7E	NM_005054	NP_005045	Q99666	RGPD5_HUMAN	RANBP2-like and GRIP domain containing 5 isoform	7					intracellular transport	cytoplasm	binding				0						ACCGCTCCACATCGGCCTTGC	0.632													9	45					0	0	0	0	C	113191010	C	C	113191010	3	2	35	1	0	0	0	0	1	0	0	0	13354	214	8	5	16382	5	RGPD5	2	113191010	Missense_Mutation	SNP	A	TCGA-BB-7872-01A-11D-2229-08	73691583	113191010	130008363	14	6739											
C1QL2	165257	broad.mit.edu	37	chr2	119914519	119914519	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgttactggcgtagtcgtaGttctggtcggcgtcctgtgc	3	14	14	10	4	1	0	0	0	1	0	4	0	2	0	1	3	2	4	1	3	3	4			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr2:119914519G>A	uc002tlo.2	-	2	1349	c.723C>T	c.(721-723)AAC>AAT	p.N241N		NM_182528	NP_872334	Q7Z5L3	C1QL2_HUMAN	complement component 1, q subcomponent-like 2	241	C1q.					collagen				pancreas(1)	1						CGTAGTCGTAGTTCTGGTCGG	0.617										HNSCC(49;0.14)			59	308					0	0	0	0	A	119914519	A	A	119914519	2	1	35	1	0	0	0	0	0	0	0	1	1968	1020	36	4		4	C1QL2	2	119914519	Silent	SNP	G	TCGA-BB-7872-01A-11D-2229-08	6723509	119914519	123284854	15	6740											
ANO7	50636	broad.mit.edu	37	chr2	242154318	242154318	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcaggaggtcctcatcccGtgagtcccccactcctccct	6	9	8	18	1	1	1	1	1	0	0	6	2	6	2	6	2	1	1	6	2	0	0	rs148954456	byFrequency	TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr2:242154318G>A	uc002wax.2	+	18	2091	c.1988_splice	c.e18+1	p.P663_splice		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long							cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						TCCTCATCCCGTGAGTCCCCC	0.642													9	39					0	0	0	0	A	242154318	A	A	242154318	5	1	35	1	0	0	0	0	0	0	1	0	702	1159	40	1	2131	1	ANO7	2	242154318	Splice_Site	SNP	G	TCGA-BB-7872-01A-11D-2229-08	122239799	242154318	1045055	16	6741											
EPHA3	2042	broad.mit.edu	37	chr3	89448519	89448519	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggcaagaggcacaaatgttAccatcagtagcctcaagcct	13	7	10	11	0	2	1	2	0	0	1	2	1	2	1	3	2	3	4	3	2	5	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr3:89448519A>T	uc003dqy.2	+	7	1708	c.1483A>T	c.(1483-1485)ACC>TCC	p.T495S	EPHA3_uc003dqx.1_Missense_Mutation_p.T495S|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	495	Extracellular (Potential).|Fibronectin type-III 2.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CACAAATGTTACCATCAGTAG	0.413										TSP Lung(6;0.00050)			14	36					0	0	0	0	T	89448519	T	T	89448519	3	4	35	1	0	0	0	0	1	0	0	0	5192	391	14	5	1509	5	EPHA3	3	89448519	Missense_Mutation	SNP	A	TCGA-BB-7872-01A-11D-2229-08		89448519	108573911	17	6742											
ALDH1L1	10840	broad.mit.edu	37	chr3	125833427	125833427	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagccttgttgaggtcacaGtcagcaaagatgatgagggg	12	8	14	7	0	2	4	2	3	0	1	2	4	2	4	1	3	2	2	1	3	1	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr3:125833427G>C	uc003eim.1	-	18	2245	c.2055C>G	c.(2053-2055)GAC>GAG	p.D685E	ALDH1L1_uc010hse.1_Intron|ALDH1L1_uc011bki.1_Missense_Mutation_p.D584E|ALDH1L1_uc003ein.1_Missense_Mutation_p.D220E	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	685	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TGAGGTCACAGTCAGCAAAGA	0.612													26	129					0	0	0	0	C	125833427	C	C	125833427	3	2	35	1	0	0	0	0	1	0	0	0	494	1020	36	4	677	4	ALDH1L1	3	125833427	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	36384908	125833427	72189003	18	6743											
HLTF	6596	broad.mit.edu	37	chr3	148760013	148760013	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtatggcaacaaatttgccGcagtctaagcaaaagaccca	16	7	8	10	1	1	1	0	0	1	1	1	1	1	1	2	1	3	4	2	1	6	3			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr3:148760013G>A	uc003ewq.1	-	19	2355	c.2137C>T	c.(2137-2139)CGG>TGG	p.R713W	HLTF_uc003ewr.1_Missense_Mutation_p.R713W|HLTF_uc003ews.1_Missense_Mutation_p.R712W|HLTF_uc010hve.1_Missense_Mutation_p.R712W	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	713					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CAAATTTGCCGCAGTCTAAGC	0.388													26	44					0	0	0	0	A	148760013	A	A	148760013	3	1	35	1	0	0	0	0	1	0	0	0	7254	1086	38	1	920	1	HLTF	3	148760013	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	22926586	148760013	49262417	19	6744											
FGFR3	2261	broad.mit.edu	37	chr4	1807820	1807820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgcaatgtgctggtgaccGaggacaacgtgatgaagatc	11	7	13	10	3	0	4	0	3	0	1	1	6	0	5	2	2	2	2	2	2	3	0			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr4:1807820G>A	uc003gdr.3	+	14	2135	c.1879G>A	c.(1879-1881)GAG>AAG	p.E627K	FGFR3_uc003gdu.2_Missense_Mutation_p.E629K|FGFR3_uc003gds.3_Missense_Mutation_p.E515K|FGFR3_uc003gdq.3_Missense_Mutation_p.E628K	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	627	Protein kinase.|Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.E627D(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GCTGGTGACCGAGGACAACGT	0.647		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				7	27					0	0	0	0	A	1807820	A	A	1807820	3	1	35	1	0	0	0	0	1	0	0	0	5899	1059	37	1	2084	1	FGFR3	4	1807820	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08		1807820	189346456	20	6745											
RASSF6	166824	broad.mit.edu	37	chr4	74464410	74464410	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcataaaaaatgttataggTcttcaataaagaattaagtt	18	14	5	4	0	3	1	2	0	1	1	3	1	3	1	0	1	0	2	0	1	10	7			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr4:74464410T>C	uc003hhd.1	-	3	310	c.187A>G	c.(187-189)ACC>GCC	p.T63A	RASSF6_uc003hhc.1_Missense_Mutation_p.T31A|RASSF6_uc010iik.1_Missense_Mutation_p.T31A|RASSF6_uc010iil.1_Intron	NM_201431	NP_958834	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family 6	63					apoptosis|signal transduction		protein binding			pancreas(2)	2	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			ATGTTATAGGTCTTCAATAAA	0.269													3	3					0	0	0	0	C	74464410	C	C	74464410	3	2	35	1	0	0	0	0	1	0	0	0	13155	1667	58	5	958	5	RASSF6	4	74464410	Missense_Mutation	SNP	T	TCGA-BB-7872-01A-11D-2229-08	72656590	74464410	116689866	21	6746											
GPRIN3	285513	broad.mit.edu	37	chr4	90169364	90169364	+	Frame_Shift_Del	DEL	C	-	-																															cgctgacgcggctgggcctgCgtgggctggctttgacggag																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr4:90169364delC	uc003hsm.1	-	2	2417	c.1898delG	c.(1897-1899)CGCfs	p.R633fs		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	633										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GCTGGGCCTGCGTGGGCTGGC	0.572													---	---	---								-	90169364	-	-	90169364	7	5	35	1	0	1	0	1	0	0	0	0	6770	768	27	0	436	0	GPRIN3	4	90169364	Frame_Shift_Del	DEL	C	TCGA-BB-7872-01A-11D-2229-08	15704954	90169364	100984912	22	6747											
GRID2	2895	broad.mit.edu	37	chr4	94411878	94411878	+	Frame_Shift_Del	DEL	G	-	-																															attgttatctcatcttacacGgcaaacctcgctgctttcct																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr4:94411878delG	uc011cdt.1	+	12	2205	c.1947delG	c.(1945-1947)ACGfs	p.T649fs	GRID2_uc011cdu.1_Frame_Shift_Del_p.T554fs	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	649	Helical; (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CATCTTACACGGCAAACCTCG	0.438													---	---	---								-	94411878	-	-	94411878	7	5	35	1	0	1	0	1	0	0	0	0	6811	1103	39	0	1993	0	GRID2	4	94411878	Frame_Shift_Del	DEL	G	TCGA-BB-7872-01A-11D-2229-08	4242514	94411878	96742398	23	6748											
FAT1	2195	broad.mit.edu	37	chr4	187539651	187539651	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaattttggaagctgcatttCcggtggaaggattttaacat	12	14	10	5	1	0	0	0	0	0	0	1	3	1	3	1	4	3	2	1	4	4	5			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr4:187539651C>A	uc003izf.2	-	10	8277	c.8089G>T	c.(8089-8091)GAA>TAA	p.E2697*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2697	Extracellular (Potential).|Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AGCTGCATTTCCGGTGGAAGG	0.393										HNSCC(5;0.00058)			27	69					5.45727e-16	6.02426e-16	1	0	A	187539651	A	A	187539651	4	1	35	1	0	0	0	0	0	1	0	0	5721	864	30	2	5749	2	FAT1	4	187539651	Nonsense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08	93127773	187539651	3614625	24	6749											
LPCAT1	79888	broad.mit.edu	37	chr5	1489905	1489907	+	In_Frame_Del	DEL	CTA	-	-																															cgcccgtctcttgatttcttCtactgttttcctgcgagaat																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr5:1489905_1489907delCTA	uc003jcm.2	-	4	677_679	c.560_562delTAG	c.(559-564)GTAGAA>GAA	p.V187del		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	187	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		TTGATTTCTTCTACTGTTTTCCT	0.512													---	---	---								-	1489907	-	-	1489905	7	5	35	1	0	1	0	1	0	0	0	0	8960	922	32	0	1086	0	LPCAT1	5	1489905	In_Frame_Del	DEL	CTA	TCGA-BB-7872-01A-11D-2229-08		1489905	179425355	25	6750											
CDH12	1010	broad.mit.edu	37	chr5	21854831	21854831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccctgaagaatgctgtaaaCgactctggcactgtttccat	10	12	8	11	1	1	2	0	1	1	1	3	3	3	2	2	1	2	4	2	1	4	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr5:21854831C>T	uc010iuc.2	-	4	1053	c.595G>A	c.(595-597)GTT>ATT	p.V199I	CDH12_uc011cno.1_Intron|CDH12_uc003jgk.2_Missense_Mutation_p.V199I	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	199	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						ATGCTGTAAACGACTCTGGCA	0.403										HNSCC(59;0.17)			13	49					0	0	0	0	T	21854831	T	T	21854831	3	4	35	1	0	0	0	0	1	0	0	0	3113	536	19	1	1825	1	CDH12	5	21854831	Missense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08	20364926	21854831	159060429	26	6751											
PCDHB11	56125	broad.mit.edu	37	chr5	140580943	140580943	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctttcgacttccgcgtgggCgccacagaccgcggctcccc	4	7	12	18	6	0	1	0	0	0	1	3	2	2	1	5	2	0	2	5	2	0	2	rs141725405	byFrequency	TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr5:140580943C>T	uc003liy.2	+	1	1596	c.1596C>T	c.(1594-1596)GGC>GGT	p.G532G	PCDHB11_uc011daj.1_Silent_p.G167G	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	532	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCGCGTGGGCGCCACAGACC	0.677													31	96					0	0	0	0	T	140580943	T	T	140580943	2	4	35	1	0	0	0	0	0	0	0	1	11590	755	27	1		1	PCDHB11	5	140580943	Silent	SNP	C	TCGA-BB-7872-01A-11D-2229-08	118726112	140580943	40334317	27	6752											
FBXO38	81545	broad.mit.edu	37	chr5	147793811	147793811	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgaagttttttcctgtatCaaatatctggcaatttacaa	14	16	5	6	0	2	1	1	1	1	0	3	1	3	1	1	1	1	3	1	1	8	7			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr5:147793811C>G	uc003lpf.1	+	10	1326	c.1206C>G	c.(1204-1206)ATC>ATG	p.I402M	FBXO38_uc003lpg.1_Missense_Mutation_p.I402M|FBXO38_uc003lph.2_Missense_Mutation_p.I402M	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	402						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTCCTGTATCAAATATCTGG	0.368													22	84					0	0	0	0	G	147793811	G	G	147793811	3	3	35	1	0	0	0	0	1	0	0	0	5778	816	29	2	1240	2	FBXO38	5	147793811	Missense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08	7212868	147793811	33121449	28	6753											
TCTE1	202500	broad.mit.edu	37	chr6	44250240	44250241	+	Frame_Shift_Ins	INS	-	A	A																															ctgggtggtccagaaggcttINScgaattatgatgcgtgcctt																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr6:44250240_44250241insA	uc003oxi.2	-	4	1058_1059	c.902_903insT	c.(901-903)CGAfs	p.R301fs	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	301										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCAGAAGGCTTCGAATTATGAT	0.564													---	---	---								A	44250241	A	A	44250240	7	5	35	1	0	1	1	0	0	0	0	0	15783	1770	62	0	610	0	TCTE1	6	44250240	Frame_Shift_Ins	INS	-	TCGA-BB-7872-01A-11D-2229-08		44250240	126864827	29	6754											
AIM1	202	broad.mit.edu	37	chr6	106968417	106968417	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggaaaaattcactgaaattAtaaaacagatggatagcgca	19	9	8	5	1	1	2	1	1	0	1	1	4	1	4	0	2	2	1	0	2	7	4			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr6:106968417A>G	uc003prh.2	+	2	2597	c.2110A>G	c.(2110-2112)ATA>GTA	p.I704V		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	704							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CACTGAAATTATAAAACAGAT	0.423													17	53					0	0	0	0	G	106968417	G	G	106968417	3	3	35	1	0	0	0	0	1	0	0	0	430	449	16	5	2116	5	AIM1	6	106968417	Missense_Mutation	SNP	A	TCGA-BB-7872-01A-11D-2229-08	62718177	106968417	64146650	30	6755											
MEOX2	4223	broad.mit.edu	37	chr7	15652168	15652168	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accagttccttttcccgagcCgcagctccttgctgtccacc	5	11	7	18	2	0	0	0	0	0	0	4	1	4	0	7	0	3	4	7	0	0	4			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr7:15652168C>T	uc003stc.2	-	3	1040	c.759G>A	c.(757-759)GCG>GCA	p.A253A	MEOX2_uc011jxw.1_Silent_p.A253A	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	253					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TTTCCCGAGCCGCAGCTCCTT	0.507													19	83					0	0	0	0	T	15652168	T	T	15652168	2	4	35	1	0	0	0	0	0	0	0	1	9527	639	23	1		1	MEOX2	7	15652168	Silent	SNP	C	TCGA-BB-7872-01A-11D-2229-08		15652168	143486495	31	6756											
ABCB5	340273	broad.mit.edu	37	chr7	20721196	20721197	+	Frame_Shift_Del	DEL	TG	-	-																															attcgaagtgcagatttgatTgtgaccctaaaggatggaat																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr7:20721196_20721197delTG	uc003suw.3	+	6	987_988	c.441_442delTG	c.(439-444)ATTGTGfs	p.I147fs	ABCB5_uc010kuh.2_Frame_Shift_Del_p.I592fs	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	147_148	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CAGATTTGATTGTGACCCTAAA	0.416													---	---	---								-	20721197	-	-	20721196	7	5	35	1	0	1	0	1	0	0	0	0	44	1800	63	0	1871	0	ABCB5	7	20721196	Frame_Shift_Del	DEL	TG	TCGA-BB-7872-01A-11D-2229-08	5069028	20721196	138417467	32	6757											
CALCR	799	broad.mit.edu	37	chr7	93055794	93055794	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attgggatgtcgccagcctcCgcagcagcggctgcagcgcg	6	6	15	14	5	0	0	0	0	0	0	2	1	1	1	3	2	5	4	3	2	0	1			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr7:93055794C>T	uc003umv.1	-	15	1662	c.1401G>A	c.(1399-1401)GCG>GCA	p.A467A	CALCR_uc011kia.1_Silent_p.A247A|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Silent_p.A433A|CALCR_uc003umw.2_Silent_p.A433A	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	449	Poly-Ala.|Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding	p.A433A(1)		ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CGCCAGCCTCCGCAGCAGCGG	0.582													26	121					0	0	0	0	T	93055794	T	T	93055794	2	4	35	1	0	0	0	0	0	0	0	1	2591	639	23	1		1	CALCR	7	93055794	Silent	SNP	C	TCGA-BB-7872-01A-11D-2229-08	72334598	93055794	66082869	33	6758											
AZGP1	563	broad.mit.edu	37	chr7	99564900	99564900	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtggctggtgaccaccacaGagggaggatctgtggaggga	9	6	19	7	0	1	2	0	1	1	1	1	6	1	6	2	7	0	1	2	7	0	0			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr7:99564900G>A	uc003ush.2	-	4	667	c.623C>T	c.(622-624)TCT>TTT	p.S208F		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	208	Ig-like C1-type.				antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					GACCACCACAGAGGGAGGATC	0.577													9	30					0	0	0	0	A	99564900	A	A	99564900	3	1	35	1	0	0	0	0	1	0	0	0	1241	942	33	2	277	2	AZGP1	7	99564900	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	6509106	99564900	59573763	34	6759											
ARMC10	83787	broad.mit.edu	37	chr7	102724150	102724151	+	Frame_Shift_Ins	INS	-	T	T																															gacttaactgatggttcataINStgatgatgttctaaatgctg																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr7:102724150_102724151insT	uc003vaw.1	+	3	658_659	c.266_267insT	c.(265-267)TATfs	p.Y89fs	ARMC10_uc003vay.1_Frame_Shift_Ins_p.Y89fs|ARMC10_uc003vax.1_Frame_Shift_Ins_p.Y54fs|ARMC10_uc003vbb.1_Frame_Shift_Ins_p.Y54fs|ARMC10_uc011kli.1_Frame_Shift_Ins_p.Y54fs|ARMC10_uc010lis.1_Frame_Shift_Ins_p.Y54fs|ARMC10_uc003vba.1_RNA|ARMC10_uc003vaz.1_5'UTR	NM_031905	NP_114111	Q8N2F6	ARM10_HUMAN	SVH protein isoform a	89					regulation of growth	endoplasmic reticulum membrane|integral to membrane	binding			ovary(1)	1						GATGGTTCATATGATGATGTTC	0.302													---	---	---								T	102724151	T	T	102724150	7	5	35	1	0	1	1	0	0	0	0	0	952	449	16	0	276	0	ARMC10	7	102724150	Frame_Shift_Ins	INS	-	TCGA-BB-7872-01A-11D-2229-08	3159250	102724150	56414513	35	6760											
METTL2B	55798	broad.mit.edu	37	chr7	128119226	128119227	+	Frame_Shift_Ins	INS	-	T	T																															tacagttgattatgagatcaINSatgcccacaaatactggaat																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr7:128119226_128119227insT	uc003vnf.2	+	3	254_255	c.217_218insT	c.(217-219)AATfs	p.N73fs	METTL2B_uc003vng.2_Frame_Shift_Ins_p.N8fs|METTL2B_uc011kop.1_Translation_Start_Site	NM_018396	NP_060866	Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	73							methyltransferase activity			skin(1)	1						TTATGAGATCAATGCCCACAAA	0.337													---	---	---								T	128119227	T	T	128119226	7	5	35	1	0	1	1	0	0	0	0	0	9553	130	5	0	227	0	METTL2B	7	128119226	Frame_Shift_Ins	INS	-	TCGA-BB-7872-01A-11D-2229-08	25395076	128119226	31019437	36	6761											
OR6V1	346517	broad.mit.edu	37	chr7	142750181	142750181	+	Frame_Shift_Del	DEL	C	-	-																															cacctcacactggtcttcatCggctacagtagtaccatctt																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr7:142750181delC	uc011ksv.1	+	1	744	c.744delC	c.(742-744)ATCfs	p.I248fs		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					TGGTCTTCATCGGCTACAGTA	0.552													---	---	---								-	142750181	-	-	142750181	7	5	35	1	0	1	0	1	0	0	0	0	11265	874	31	0	746	0	OR6V1	7	142750181	Frame_Shift_Del	DEL	C	TCGA-BB-7872-01A-11D-2229-08	14630955	142750181	16388482	37	6762											
RAB11FIP1	80223	broad.mit.edu	37	chr8	37756684	37756684	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgagcagcgcgcggtgcagCacggtgagctgcagggtggc	6	4	19	12	5	0	1	0	1	0	0	0	2	0	1	1	4	6	5	1	4	0	0			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr8:37756684C>T	uc003xkm.1	-	1	320	c.276G>A	c.(274-276)GTG>GTA	p.V92V	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Silent_p.V92V	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	92	C2.				protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CGCGGTGCAGCACGGTGAGCT	0.741													3	6					0	0	0	0	T	37756684	T	T	37756684	2	4	35	1	0	0	0	0	0	0	0	1	12958	697	25	4		4	RAB11FIP1	8	37756684	Silent	SNP	C	TCGA-BB-7872-01A-11D-2229-08		37756684	108607338	38	6763											
FBXO43	286151	broad.mit.edu	37	chr8	101153496	101153496	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccactgtcttcaggcgttGaaatactgcctctcacttca	10	12	6	13	1	4	1	3	1	2	0	5	1	4	1	2	1	3	1	2	1	3	4			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr8:101153496G>C	uc003yjd.2	-	2	1699	c.986C>G	c.(985-987)TCA>TGA	p.S329*	FBXO43_uc003yje.2_Nonsense_Mutation_p.S295*|FBXO43_uc010mbp.1_Nonsense_Mutation_p.S329*	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	329					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TTCAGGCGTTGAAATACTGCC	0.408													16	83					0	0	0	0	C	101153496	C	C	101153496	4	2	35	1	0	0	0	0	0	1	0	0	5784	1294	45	2	1156	2	FBXO43	8	101153496	Nonsense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	63396812	101153496	45210526	39	6764											
FER1L6	654463	broad.mit.edu	37	chr8	125082795	125082795	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagaggcaagtctacggaaGatgaccatggtcttgatgga	12	9	13	7	1	3	4	1	2	2	2	3	6	3	6	1	4	1	1	1	4	3	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr8:125082795G>C	uc003yqw.2	+	30	4128	c.3922G>C	c.(3922-3924)GAT>CAT	p.D1308H	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1308	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GTCTACGGAAGATGACCATGG	0.403													22	122					0	0	0	0	C	125082795	C	C	125082795	3	2	35	1	0	0	0	0	1	0	0	0	5847	942	33	2	4036	2	FER1L6	8	125082795	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	23929299	125082795	21281227	40	6765											
ABCA1	19	broad.mit.edu	37	chr9	107602634	107602634	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagggctttgtagttgttgTcctcataccagttgagagac	9	13	12	7	0	1	3	1	1	0	2	2	4	2	3	2	1	1	5	2	1	2	6			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr9:107602634T>G	uc004bcl.2	-	9	1293	c.980A>C	c.(979-981)GAC>GCC	p.D327A		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	327	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTAGTTGTTGTCCTCATACCA	0.532													26	64					0	0	0	0	G	107602634	G	G	107602634	3	3	35	1	0	0	0	0	1	0	0	0	28	1667	58	5	5973	5	ABCA1	9	107602634	Missense_Mutation	SNP	T	TCGA-BB-7872-01A-11D-2229-08		107602634	33610797	41	6766											
NOTCH1	4851	broad.mit.edu	37	chr9	139407990	139407990	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcacagtcgcacttgtacCtgcaagggggaccacactgc	9	7	12	13	1	1	0	1	0	0	0	2	1	1	1	2	3	3	3	2	3	2	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr9:139407990C>T	uc004chz.2	-	14	2208	c.2208_splice	c.e14-1	p.G736_splice	NOTCH1_uc004cia.1_5'UTR	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein						aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCACTTGTACCTGCAAGGGGG	0.627			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			12	42					0	0	0	0	T	139407990	T	T	139407990	5	4	35	1	0	0	0	0	0	0	1	0	10601	695	24	4	5544	4	NOTCH1	9	139407990	Splice_Site	SNP	C	TCGA-BB-7872-01A-11D-2229-08	31805356	139407990	1805441	42	6767											
OR6A2	8590	broad.mit.edu	37	chr11	6816289	6816290	+	Frame_Shift_Del	DEL	AG	-	-																															acataggaggccccagtgacAgagagtggccctagaagaat																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr11:6816289_6816290delAG	uc001mes.1	-	1	850_851	c.650_651delCT	c.(649-651)TCTfs	p.S217fs		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCCCAGTGACAGAGAGTGGCCC	0.5													---	---	---								-	6816290	-	-	6816289	7	5	35	1	0	1	0	1	0	0	0	0	11240	175	7	0	336	0	OR6A2	11	6816289	Frame_Shift_Del	DEL	AG	TCGA-BB-7872-01A-11D-2229-08		6816289	128190227	43	6768											
ALDH3B1	221	broad.mit.edu	37	chr11	67787207	67787207	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctttgctgtggtgctgggCgggccccaggagacggggca	4	8	19	10	2	0	1	0	0	0	1	0	2	0	1	2	6	3	4	2	6	0	1			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr11:67787207C>T	uc010rpy.1	+	7	620	c.504C>T	c.(502-504)GGC>GGT	p.G168G	ALDH3B1_uc001omz.2_Silent_p.G168G|ALDH3B1_uc001ona.2_Silent_p.G131G|ALDH3B1_uc001onb.2_RNA	NM_001161473	NP_001154945	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3B1 isoform a	168					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase				0					NADH(DB00157)	TGGTGCTGGGCGGGCCCCAGG	0.667													41	151					0	0	0	0	T	67787207	T	T	67787207	2	4	35	1	0	0	0	0	0	0	0	1	499	755	27	1		1	ALDH3B1	11	67787207	Silent	SNP	C	TCGA-BB-7872-01A-11D-2229-08	60970918	67787207	67219309	44	6769											
SCN3B	55800	broad.mit.edu	37	chr11	123513320	123513320	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtccttgctgccattccaCtgcaggcgcccctgaaaggg	7	8	12	14	1	0	1	0	1	0	0	2	1	2	1	5	3	3	2	5	3	1	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr11:123513320C>T	uc001pza.1	-	4	686	c.279G>A	c.(277-279)CAG>CAA	p.Q93Q	SCN3B_uc001pzb.1_Silent_p.Q93Q	NM_001040151	NP_001035241	Q9NY72	SCN3B_HUMAN	voltage-gated sodium channel beta-3 subunit	93	Ig-like C2-type.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		TGCCATTCCACTGCAGGCGCC	0.572													14	58					0	0	0	0	T	123513320	T	T	123513320	2	4	35	1	0	0	0	0	0	0	0	1	13984	564	20	4		4	SCN3B	11	123513320	Silent	SNP	C	TCGA-BB-7872-01A-11D-2229-08	55726113	123513320	11493196	45	6770											
A2ML1	144568	broad.mit.edu	37	chr12	8994121	8994121	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccggttggaatgggacagacGtttctctggaggtaagcatg	9	10	15	7	2	1	1	0	0	1	1	2	4	1	4	1	5	1	4	1	5	2	3			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr12:8994121G>A	uc001quz.3	+	11	1335	c.1237G>A	c.(1237-1239)GTT>ATT	p.V413I	A2ML1_uc001qva.1_5'Flank	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	257						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						TGGGACAGACGTTTCTCTGGA	0.478													9	31					0	0	0	0	A	8994121	A	A	8994121	3	1	35	1	0	0	0	0	1	0	0	0	5	1145	40	1	1279	1	A2ML1	12	8994121	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08		8994121	124857774	46	6771											
PRB1	5542	broad.mit.edu	37	chr12	11506214	11506214	+	Frame_Shift_Del	DEL	G	-	-																															tggctttcctggaggagatcGggcactttgggacttgctgc																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr12:11506214delG	uc001qzw.1	-	4	860	c.823delC	c.(823-825)CGAfs	p.R275fs	PRB1_uc001qzu.1_Frame_Shift_Del_p.R142fs|PRB1_uc001qzv.1_Frame_Shift_Del_p.R122fs	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	336	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].|14.					extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGAGGAGATCGGGCACTTTGG	0.607													---	---	---								-	11506214	-	-	11506214	7	5	35	1	0	1	0	1	0	0	0	0	12504	1124	39	0	176	0	PRB1	12	11506214	Frame_Shift_Del	DEL	G	TCGA-BB-7872-01A-11D-2229-08	2512093	11506214	122345681	47	6772											
ZIC2	7546	broad.mit.edu	37	chr13	100635305	100635305	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacatccgcgtgcacacaggCgagaaacccttcccctgccc	9	5	8	19	3	0	1	0	0	0	1	2	2	2	1	5	1	3	1	5	1	1	1			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr13:100635305C>T	uc001von.2	+	1	987	c.987C>T	c.(985-987)GGC>GGT	p.G329G		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	329					brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGCACACAGGCGAGAAACCCT	0.607													57	85					0	0	0	0	T	100635305	T	T	100635305	2	4	35	1	0	0	0	0	0	0	0	1	17746	755	27	1		1	ZIC2	13	100635305	Silent	SNP	C	TCGA-BB-7872-01A-11D-2229-08		100635305	14534573	48	6773											
GRTP1	79774	broad.mit.edu	37	chr13	114018615	114018616	+	5'Flank	INS	-	G	G																															ggagcacccagggcgggggaINSggggcggggctgggggcggg																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr13:114018615_114018616insG	uc001vtn.2	-						GRTP1_uc010tkc.1_5'Flank|GRTP1_uc010agv.1_5'Flank	NM_024719	NP_078995	Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1							intracellular	Rab GTPase activator activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			agggcgggggaggggcggggct	0													---	---	---								G	114018616	G	G	114018615	6	5	35	0	1	1	1	0	0	0	0	0	6849	319	11	0		0	GRTP1	13	114018615	5'Flank	INS	-	TCGA-BB-7872-01A-11D-2229-08	13383310	114018615	1151263	49	6774											
CPSF2	53981	broad.mit.edu	37	chr14	92597374	92597374	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctttctggggtccaagaaGaatctgccctttgctatctt	7	14	8	12	0	3	2	0	0	3	2	4	2	4	2	3	2	2	1	3	2	4	4			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr14:92597374G>A	uc001yah.1	+	3	283	c.46G>A	c.(46-48)GAA>AAA	p.E16K		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	16					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		GGTCCAAGAAGAATCTGCCCT	0.373													17	78					0	0	0	0	A	92597374	A	A	92597374	3	1	35	1	0	0	0	0	1	0	0	0	3840	943	33	2	48	2	CPSF2	14	92597374	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08		92597374	14752166	50	6775											
RTF1	23168	broad.mit.edu	37	chr15	41767764	41767764	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttccgtttagagtttgtctCaaaccaagaattcaccgaaa	13	12	7	9	2	2	2	2	0	1	2	4	3	3	2	3	0	1	3	3	0	5	5			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr15:41767764C>G	uc001zny.2	+	10	1340	c.1328C>G	c.(1327-1329)TCA>TGA	p.S443*		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	443	Plus3.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		GAGTTTGTCTCAAACCAAGAA	0.423													14	69					0	0	0	0	G	41767764	G	G	41767764	4	3	35	1	0	0	0	0	0	1	0	0	13786	838	29	2	1366	2	RTF1	15	41767764	Nonsense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08		41767764	60763628	51	6776											
MPI	4351	broad.mit.edu	37	chr15	75185035	75185035	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgcacctccaggctccgCagcactaccccgatgccaac	9	5	8	19	2	0	0	0	0	0	0	2	1	2	0	6	1	6	5	6	1	2	1			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr15:75185035C>T	uc002azc.1	+	4	384	c.379C>T	c.(379-381)CAG>TAG	p.Q127*	MPI_uc010ulv.1_Nonsense_Mutation_p.Q127*|MPI_uc010ulw.1_Nonsense_Mutation_p.Q77*|MPI_uc002azd.1_Nonsense_Mutation_p.Q127*|MPI_uc010ulx.1_Nonsense_Mutation_p.Q77*|MPI_uc002aze.1_Nonsense_Mutation_p.Q127*	NM_002435	NP_002426	P34949	MPI_HUMAN	mannose-6- phosphate isomerase	127					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			ovary(2)	2						CCAGGCTCCGCAGCACTACCC	0.602													13	53					0	0	0	0	T	75185035	T	T	75185035	4	4	35	1	0	0	0	0	0	1	0	0	9782	711	25	4	393	4	MPI	15	75185035	Nonsense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08	33417271	75185035	27346357	52	6777											
MCTP2	55784	broad.mit.edu	37	chr15	94841555	94841555	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggaccaggccattgttgAtcaacttgagcaagaagaag	14	7	12	8	1	1	4	1	2	0	2	1	5	1	5	2	2	3	2	2	2	4	3			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr15:94841555A>C	uc002btj.2	+	1	126	c.61A>C	c.(61-63)ATC>CTC	p.I21L	MCTP2_uc010urg.1_Missense_Mutation_p.I21L|MCTP2_uc002bti.2_Missense_Mutation_p.I21L|MCTP2_uc010boj.2_5'UTR|MCTP2_uc010bok.2_Missense_Mutation_p.I21L|MCTP2_uc002btg.3_Missense_Mutation_p.I21L|MCTP2_uc002bth.3_Missense_Mutation_p.I21L	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	21					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GCCATTGTTGATCAACTTGAG	0.502													13	48					0	0	0	0	C	94841555	C	C	94841555	3	2	35	1	0	0	0	0	1	0	0	0	9454	333	12	5	63	5	MCTP2	15	94841555	Missense_Mutation	SNP	A	TCGA-BB-7872-01A-11D-2229-08	19656520	94841555	7689837	53	6778											
OR4F6	390648	broad.mit.edu	37	chr15	102346083	102346083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aactgtgacctctgaccctcGtttacagtcccccatgtact	8	12	6	15	1	1	2	0	2	1	0	3	2	2	2	4	0	3	2	4	0	3	3	rs61746768	byFrequency	TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr15:102346083G>A	uc010utr.1	+	1	161	c.161G>A	c.(160-162)CGT>CAT	p.R54H		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TCTGACCCTCGTTTACAGTCC	0.468													60	327					0	0	0	0	A	102346083	A	A	102346083	3	1	35	1	0	0	0	0	1	0	0	0	11120	1145	40	1	163	1	OR4F6	15	102346083	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	7504528	102346083	185309	54	6779											
CREBBP	1387	broad.mit.edu	37	chr16	3781324	3781326	+	In_Frame_Del	DEL	AGG	-	-																															ggaccacttggagcggcgcaAggaggagaactcccagtgct																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr16:3781324_3781326delAGG	uc002cvv.2	-	30	5243_5245	c.5039_5041delCCT	c.(5038-5043)TCCTTG>TTG	p.S1680del	CREBBP_uc002cvw.2_In_Frame_Del_p.S1642del	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1680	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GAGCGGCGCAAGGAGGAGAACTC	0.645			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				---	---	---								-	3781326	-	-	3781324	7	5	35	1	0	1	0	1	0	0	0	0	3876	69	3	0	2295	0	CREBBP	16	3781324	In_Frame_Del	DEL	AGG	TCGA-BB-7872-01A-11D-2229-08		3781324	86573429	55	6780											
SPACA3	124912	broad.mit.edu	37	chr17	31322641	31322641	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctcagctgcctgctaccCtccagtgaggccaagctcta	7	9	9	16	0	2	1	1	1	1	0	3	1	3	1	4	1	6	4	4	1	3	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr17:31322641C>T	uc002hhs.1	+	2	324	c.249C>T	c.(247-249)CCC>CCT	p.P83P	SPACA3_uc010cte.1_RNA	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	83	Helical; Signal-anchor for type II membrane protein; (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			GCCTGCTACCCTCCAGTGAGG	0.612													15	74					0	0	0	0	T	31322641	T	T	31322641	2	4	35	1	0	0	0	0	0	0	0	1	15037	668	24	4		4	SPACA3	17	31322641	Silent	SNP	C	TCGA-BB-7872-01A-11D-2229-08		31322641	49872569	56	6781											
EMILIN2	84034	broad.mit.edu	37	chr18	2890969	2890969	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaaaagtgacaagctggaaGagctggatggaaaagtgaag	18	5	14	4	0	0	3	0	2	0	1	0	6	0	6	0	3	2	2	0	3	7	0			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr18:2890969G>C	uc002kln.2	+	4	1003	c.844G>C	c.(844-846)GAG>CAG	p.E282Q		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	282	Potential.				cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CAAGCTGGAAGAGCTGGATGG	0.493													13	45					0	0	0	0	C	2890969	C	C	2890969	3	2	35	1	0	0	0	0	1	0	0	0	5118	943	33	2	858	2	EMILIN2	18	2890969	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08		2890969	75186279	57	6782											
RBBP8	5932	broad.mit.edu	37	chr18	20548852	20548852	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagtttgaaaatatccggcAgcagaatcttaaacttatta	16	12	7	6	1	1	3	0	1	1	2	2	3	2	3	1	1	2	3	1	1	8	5			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr18:20548852A>T	uc002ktw.2	+	5	663	c.332A>T	c.(331-333)CAG>CTG	p.Q111L	RBBP8_uc002kty.2_Missense_Mutation_p.Q111L|RBBP8_uc002ktz.2_Missense_Mutation_p.Q111L|RBBP8_uc002kua.2_Missense_Mutation_p.Q111L|RBBP8_uc002ktx.1_Missense_Mutation_p.Q111L	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	111	Potential.				cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			AATATCCGGCAGCAGAATCTT	0.318								Direct_reversal_of_damage|Homologous_recombination					12	32					0	0	0	0	T	20548852	T	T	20548852	3	4	35	1	0	0	0	0	1	0	0	0	13170	188	7	5	346	5	RBBP8	18	20548852	Missense_Mutation	SNP	A	TCGA-BB-7872-01A-11D-2229-08	17657883	20548852	57528396	58	6783											
PLIN5	440503	broad.mit.edu	37	chr19	4523641	4523642	+	In_Frame_Ins	INS	-	CCCATT	CCCATT																															acacccatcctgtccccatcINScccattcccactcccgtccc																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr19:4523641_4523642insCCCATT	uc002mas.2	-	8	1343_1344	c.1290_1291insAATGGG	c.(1288-1293)insAATGGG	p.430_431insNG		NM_001013706	NP_001013728	Q00G26	PLIN5_HUMAN	lipid storage droplet protein 5	430_431						lipid particle					0						CTGTCCCCATCCCCATTCCCAC	0.688											OREG0025168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								CCCATT	4523642	CCCATT	CCCATT	4523641	7	5	35	1	0	1	1	0	0	0	0	0	12148	855	30	0	104	0	PLIN5	19	4523641	In_Frame_Ins	INS	-	TCGA-BB-7872-01A-11D-2229-08		4523641	54605342	59	6784											
AKAP8	10270	broad.mit.edu	37	chr19	15466133	15466135	+	In_Frame_Del	DEL	CTC	-	-																															ctcacctcctaaattgtcatCtccttccatttctggatcaa																										TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr19:15466133_15466135delCTC	uc002nav.2	-	14	1731_1733	c.1670_1672delGAG	c.(1669-1674)GGAGAT>GAT	p.G557del	AKAP8_uc010dzy.2_In_Frame_Del_p.G106del	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	557					signal transduction	nuclear matrix				ovary(1)|breast(1)	2						AAATTGTCATCTCCTTCCATTTC	0.542													---	---	---								-	15466135	-	-	15466133	7	5	35	1	0	1	0	1	0	0	0	0	457	913	32	0	410	0	AKAP8	19	15466133	In_Frame_Del	DEL	CTC	TCGA-BB-7872-01A-11D-2229-08	10942492	15466133	43662850	60	6785											
NLRP9	338321	broad.mit.edu	37	chr19	56243935	56243935	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatcacgccctcagactcaGataacccattcctccggaga	12	7	6	16	2	3	3	3	0	0	3	5	4	5	3	4	1	1	0	4	1	1	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr19:56243935G>C	uc002qly.2	-	2	1290	c.1262C>G	c.(1261-1263)TCT>TGT	p.S421C		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	421	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CTCAGACTCAGATAACCCATT	0.498													41	85					0	0	0	0	C	56243935	C	C	56243935	3	2	35	1	0	0	0	0	1	0	0	0	10538	942	33	2	1745	2	NLRP9	19	56243935	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	40777802	56243935	2885048	61	6786											
HCK	3055	broad.mit.edu	37	chr20	30662496	30662496	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcccaagcaactatgtcGcccgcgttgactctctggag	9	9	9	14	3	1	1	0	1	1	0	4	2	2	2	2	1	2	2	2	1	3	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr20:30662496G>A	uc002wxh.2	+	5	571	c.400G>A	c.(400-402)GCC>ACC	p.A134T	HCK_uc010gdy.2_Missense_Mutation_p.A113T|HCK_uc002wxi.2_Missense_Mutation_p.A112T	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	134	SH3.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CAACTATGTCGCCCGCGTTGA	0.468													89	185					0	0	0	0	A	30662496	A	A	30662496	3	1	35	1	0	0	0	0	1	0	0	0	7033	1087	38	1	424	1	HCK	20	30662496	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08		30662496	32363024	62	6787											
SCUBE1	80274	broad.mit.edu	37	chr22	43614380	43614380	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggacatagaactgctgcCggccgatggacttgcgcagg	8	7	14	12	3	0	1	0	0	0	1	0	4	0	3	3	4	4	2	3	4	2	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chr22:43614380C>T	uc003bdt.1	-	15	1860	c.1772G>A	c.(1771-1773)CGG>CAG	p.R591Q		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	591					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				GAACTGCTGCCGGCCGATGGA	0.652													43	235					0	0	0	0	T	43614380	T	T	43614380	3	4	35	1	0	0	0	0	1	0	0	0	14009	652	23	1	1226	1	SCUBE1	22	43614380	Missense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08		43614380	7690186	63	6788											
EDA	1896	broad.mit.edu	37	chrX	68836326	68836326	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctccacctgctgacgttGtgctgctacctagagttgcg	5	11	11	14	2	0	2	0	1	0	1	1	2	1	2	4	0	5	5	4	0	2	4			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:68836326G>C	uc004dxs.2	+	1	416	c.174G>C	c.(172-174)TTG>TTC	p.L58F	EDA_uc004dxr.2_Missense_Mutation_p.L58F|EDA_uc011mpj.1_Missense_Mutation_p.L58F|EDA_uc004dxn.1_Missense_Mutation_p.L58F|EDA_uc004dxm.1_Missense_Mutation_p.L58F|EDA_uc004dxp.1_Missense_Mutation_p.L58F|EDA_uc004dxq.1_Missense_Mutation_p.L58F|EDA_uc004dxl.1_Missense_Mutation_p.L58F	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	58	Helical; Signal-anchor for type II membrane protein; (Potential).				cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						TGCTGACGTTGTGCTGCTACC	0.692													12	53					0	0	0	0	C	68836326	C	C	68836326	3	2	35	1	0	0	0	0	1	0	0	0	4925	1368	48	4	176	4	EDA	23	68836326	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08		68836326	86434234	64	6789											
TBX22	50945	broad.mit.edu	37	chrX	79281198	79281198	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacccggactcaccctgctcGggagagacctggatgcggca	8	5	13	15	3	1	1	1	0	0	1	2	5	1	4	3	4	2	2	3	4	0	0			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:79281198G>A	uc010nmg.1	+	5	689	c.555G>A	c.(553-555)TCG>TCA	p.S185S	TBX22_uc004edi.1_Silent_p.S65S|TBX22_uc004edj.1_Silent_p.S185S	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	185	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CACCCTGCTCGGGAGAGACCT	0.493													9	22					0	0	0	0	A	79281198	A	A	79281198	2	1	35	1	0	0	0	0	0	0	0	1	15724	1103	39	1		1	TBX22	23	79281198	Silent	SNP	G	TCGA-BB-7872-01A-11D-2229-08	10444872	79281198	75989362	65	6790											
PABPC5	140886	broad.mit.edu	37	chrX	90690749	90690749	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgatccggtgacccgcagccCcctgggctatgggtatgtta	6	10	13	12	2	0	2	0	2	0	0	1	2	1	2	4	3	1	4	4	3	3	3			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:90690749C>T	uc004efg.2	+	2	613	c.173C>T	c.(172-174)CCC>CTC	p.P58L	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	58	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						ACCCGCAGCCCCCTGGGCTAT	0.532													5	8					0	0	0	0	T	90690749	T	T	90690749	3	4	35	1	0	0	0	0	1	0	0	0	11421	623	22	4	175	4	PABPC5	23	90690749	Missense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08	11409551	90690749	64579811	66	6791											
GUCY2F	2986	broad.mit.edu	37	chrX	108696910	108696910	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtccaggattacatattctGaaattccatttccatttgaa	12	16	5	8	0	1	2	0	2	1	0	4	3	4	3	3	1	1	0	3	1	4	6			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:108696910G>A	uc004eod.3	-	4	1487	c.1211C>T	c.(1210-1212)TCA>TTA	p.S404L	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	404	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TACATATTCTGAAATTCCATT	0.478													10	37					0	0	0	0	A	108696910	A	A	108696910	3	1	35	1	0	0	0	0	1	0	0	0	6937	1294	45	2	2179	2	GUCY2F	23	108696910	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	18006161	108696910	46573650	67	6792											
CHRDL1	91851	broad.mit.edu	37	chrX	109943935	109943935	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatcagaatgttcccatgAcagttctccatctcctgttt	9	14	5	13	0	3	2	1	1	2	1	6	2	4	2	4	0	0	3	4	0	1	3			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:109943935A>T	uc004eou.3	-	7	905	c.556T>A	c.(556-558)TCA>ACA	p.S186T	CHRDL1_uc004eov.2_Missense_Mutation_p.S180T|CHRDL1_uc004eow.2_Missense_Mutation_p.S185T|CHRDL1_uc010nps.2_Missense_Mutation_p.S185T|CHRDL1_uc004eot.2_Missense_Mutation_p.S106T|CHRDL1_uc011mss.1_Missense_Mutation_p.S100T	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	179					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						TGTTCCCATGACAGTTCTCCA	0.398													16	41					0	0	0	0	T	109943935	T	T	109943935	3	4	35	1	0	0	0	0	1	0	0	0	3388	275	10	5	844	5	CHRDL1	23	109943935	Missense_Mutation	SNP	A	TCGA-BB-7872-01A-11D-2229-08	1247025	109943935	45326625	68	6793											
KLHL13	90293	broad.mit.edu	37	chrX	117043645	117043645	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatggcagtcctgtctgactGcataactggctgcatatatg	10	12	10	9	0	1	1	0	1	1	0	2	1	2	1	1	2	3	4	1	2	4	3			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:117043645G>A	uc004eql.2	-	5	1047	c.985C>T	c.(985-987)CAG>TAG	p.Q329*	KLHL13_uc004eqk.2_Nonsense_Mutation_p.Q278*|KLHL13_uc011mtn.1_Nonsense_Mutation_p.Q169*|KLHL13_uc011mto.1_Nonsense_Mutation_p.Q323*|KLHL13_uc011mtp.1_Nonsense_Mutation_p.Q331*|KLHL13_uc004eqm.2_Nonsense_Mutation_p.Q278*|KLHL13_uc011mtq.1_Nonsense_Mutation_p.Q313*	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	329					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						CTGTCTGACTGCATAACTGGC	0.463													17	51					0	0	0	0	A	117043645	A	A	117043645	4	1	35	1	0	0	0	0	0	1	0	0	8408	1328	46	4	994	4	KLHL13	23	117043645	Nonsense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	7099710	117043645	38226915	69	6794											
RPL39	6170	broad.mit.edu	37	chrX	118920677	118920677	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttggttcttctccaatgTctccttttggagttgtacct	5	18	8	10	0	3	0	0	0	3	0	5	1	3	1	3	2	2	4	3	2	2	7	rs139139562	byFrequency	TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:118920677T>C	uc004erx.1	-	3	193	c.126A>G	c.(124-126)AGA>AGG	p.R42R		NM_001000	NP_000991	P62891	RL39_HUMAN	ribosomal protein L39	42					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0						TTCTCCAATGTCTCCTTTTGG	0.408													12	50					0	0	0	0	C	118920677	C	C	118920677	2	2	35	1	0	0	0	0	0	0	0	1	13657	1664	58	5		5	RPL39	23	118920677	Silent	SNP	T	TCGA-BB-7872-01A-11D-2229-08	1877032	118920677	36349883	70	6795											
GPC4	2239	broad.mit.edu	37	chrX	132438874	132438874	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttggcctgtttcagtttctCcttgacatcagtaacctaat	8	16	6	11	0	3	1	2	1	1	0	4	1	3	1	3	1	1	3	3	1	2	6			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:132438874C>G	uc004exc.1	-	7	1383	c.1171G>C	c.(1171-1173)GAG>CAG	p.E391Q	GPC4_uc011mvg.1_Missense_Mutation_p.E321Q	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	391					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					TTCAGTTTCTCCTTGACATCA	0.428													13	22					0	0	0	0	G	132438874	G	G	132438874	3	3	35	1	0	0	0	0	1	0	0	0	6638	864	30	2	511	2	GPC4	23	132438874	Missense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08	13518197	132438874	22831686	71	6796											
MAP7D3	79649	broad.mit.edu	37	chrX	135303033	135303033	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acggacctggctggtaccatCttctagaaataccagcttgt	10	11	9	11	1	2	1	0	0	2	1	2	2	2	2	3	3	3	3	3	3	4	5			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:135303033C>T	uc004ezt.2	-	16	2468	c.2377G>A	c.(2377-2379)GAT>AAT	p.D793N	MAP7D3_uc004ezs.2_Missense_Mutation_p.D757N|MAP7D3_uc011mwc.1_Missense_Mutation_p.D775N|MAP7D3_uc010nsa.1_Missense_Mutation_p.D751N	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	793						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					CTGGTACCATCTTCTAGAAAT	0.378													65	131					0	0	0	0	T	135303033	T	T	135303033	3	4	35	1	0	0	0	0	1	0	0	0	9322	913	32	2	265	2	MAP7D3	23	135303033	Missense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08	2864159	135303033	19967527	72	6797											
SOX3	6658	broad.mit.edu	37	chrX	139585912	139585912	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggtcagcggcaccgttccGttgactgcagtcccggcgcc	4	8	14	15	5	1	1	1	1	0	0	3	1	3	1	4	3	2	4	4	3	0	2			TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:139585912G>A	uc004fbd.1	-	1	1314	c.1314C>T	c.(1312-1314)AAC>AAT	p.N438N		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	438					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					GCACCGTTCCGTTGACTGCAG	0.592													5	10					0	0	0	0	A	139585912	A	A	139585912	2	1	35	1	0	0	0	0	0	0	0	1	15015	1136	40	1		1	SOX3	23	139585912	Silent	SNP	G	TCGA-BB-7872-01A-11D-2229-08	4282879	139585912	15684648	73	6798											
OPN1MW	2652	broad.mit.edu	37	chrX	153496125	153496125	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttctgctggggaccctacGccttcttcgcatgctttgct	3	14	10	14	2	2	0	0	0	2	0	3	1	2	1	2	2	4	5	2	2	1	5	rs1065438	byFrequency	TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:153496125G>A	uc004fkd.2	+	5	935	c.853G>A	c.(853-855)GCC>ACC	p.A285T		NM_000513	NP_000504	P04001	OPSG_HUMAN	opsin 1 (cone pigments), medium-wave-sensitive	285	Helical; Name=6; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGACCCTACGCCTTCTTCGC	0.567													32	2					0	0	0	0	A	153496125	A	A	153496125	3	1	35	1	0	0	0	0	1	0	0	0	10932	1087	38	1	1990	1	OPN1MW	23	153496125	Missense_Mutation	SNP	G	TCGA-BB-7872-01A-11D-2229-08	13910213	153496125	1774435	74	6799											
PLXNA3	55558	broad.mit.edu	37	chrX	153688695	153688695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accgagtctttaagctggccCccaacctgactgagctgcgg	8	8	11	14	2	1	2	0	2	1	0	1	3	1	2	4	2	4	2	4	2	2	2	rs147019078	byFrequency	TCGA-BB-7872-01A-11D-2229-08	TCGA-BB-7872-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	c05cb0b5-b288-48fb-bdc0-ee9acd6643a8	02e5dbe6-3c6f-4696-80bc-5b5ddb764980	g.chrX:153688695C>T	uc004flm.2	+	2	345	c.172C>T	c.(172-174)CCC>TCC	p.P58S		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	58	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TAAGCTGGCCCCCAACCTGAC	0.672													7	24					0	0	0	0	T	153688695	T	T	153688695	3	4	35	1	0	0	0	0	1	0	0	0	12176	623	22	4	174	4	PLXNA3	23	153688695	Missense_Mutation	SNP	C	TCGA-BB-7872-01A-11D-2229-08	192570	153688695	1581865	75	6800											
PLEKHN1	84069	broad.mit.edu	37	chr1	909868	909868	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccccggctacgaccacctCtgggacgagactttgtcttc	7	9	10	15	3	2	1	0	0	2	1	3	5	2	2	4	2	1	1	4	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:909868C>T	uc001ace.2	+	15	1940	c.1905C>T	c.(1903-1905)CTC>CTT	p.L635L	PLEKHN1_uc001acd.2_Silent_p.L583L|PLEKHN1_uc001acf.2_Silent_p.L548L	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	635											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		ACGACCACCTCTGGGACGAGA	0.647													12	50					0	0	0	0	T	909868	T	T	909868	2	4	36	1	0	0	0	0	0	0	0	1	12138	900	32	2		2	PLEKHN1	1	909868	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08		909868	248340753	1	6801											
PLEKHG5	57449	broad.mit.edu	37	chr1	6528107	6528107	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccagggctaggggcccctCggcaatcccagctgggccca	6	5	14	16	1	0	0	0	0	0	0	2	0	1	0	5	5	2	3	5	5	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:6528107C>T	uc001ano.1	-	21	3058	c.2957G>A	c.(2956-2958)CGA>CAA	p.R986Q	PLEKHG5_uc001ann.1_Missense_Mutation_p.R967Q|PLEKHG5_uc001anq.1_Intron|PLEKHG5_uc001anp.1_Missense_Mutation_p.R1007Q|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Missense_Mutation_p.R491Q|PLEKHG5_uc009vma.1_Missense_Mutation_p.R770Q|PLEKHG5_uc010nzr.1_Missense_Mutation_p.R999Q|PLEKHG5_uc001ank.1_Missense_Mutation_p.R930Q|PLEKHG5_uc009vmb.1_Intron|PLEKHG5_uc001anl.1_Missense_Mutation_p.R930Q|PLEKHG5_uc001anm.1_Missense_Mutation_p.R930Q|PLEKHG5_uc001anr.1_Missense_Mutation_p.R193Q	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	986					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		AGGGGCCCCTCGGCAATCCCA	0.697													4	10					0	0	0	0	T	6528107	T	T	6528107	3	4	36	1	0	0	0	0	1	0	0	0	12128	884	31	1	239	1	PLEKHG5	1	6528107	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5618239	6528107	242722514	2	6802											
ZBTB48	3104	broad.mit.edu	37	chr1	6648384	6648384	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaccggggaaaggcccttCagttgcgagttctgtgaaca	10	8	12	11	2	2	1	1	1	1	0	2	3	2	2	2	3	2	2	2	3	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:6648384C>T	uc009vmc.1	+	9	1686	c.1563C>T	c.(1561-1563)TTC>TTT	p.F521F	ZBTB48_uc001anx.2_Silent_p.F521F|ZBTB48_uc009vmd.1_Silent_p.F521F|ZBTB48_uc001any.1_Silent_p.F159F	NM_005341	NP_005332	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	521	C2H2-type 9.					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		AAAGGCCCTTCAGTTGCGAGT	0.642													26	58					0	0	0	0	T	6648384	T	T	6648384	2	4	36	1	0	0	0	0	0	0	0	1	17616	825	29	2		2	ZBTB48	1	6648384	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	120277	6648384	242602237	3	6803											
AADACL4	343066	broad.mit.edu	37	chr1	12726745	12726745	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttatataaagggcatatGatagtaaccctggggccccg	12	9	11	9	1	0	1	0	1	0	0	0	1	0	1	3	3	1	3	3	3	7	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:12726745G>A	uc001auf.2	+	4	1223	c.1223G>A	c.(1222-1224)TGA>TAA	p.*408*		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	408						integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		AAGGGCATATGATAGTAACCC	0.438													39	128					0	0	0	0	A	12726745	A	A	12726745	2	1	36	1	0	0	0	0	0	0	0	1	13	1285	45	2		2	AADACL4	1	12726745	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	6078361	12726745	236523876	4	6804											
PRAMEF12	390999	broad.mit.edu	37	chr1	12835020	12835020	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gattcatcaggatgagcctcCaggccccacctagactcctg	9	8	9	15	0	2	2	2	1	0	1	4	4	4	3	6	2	1	0	6	2	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:12835020C>T	uc001aui.2	+	1	37	c.10C>T	c.(10-12)CAG>TAG	p.Q4*		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	4										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GATGAGCCTCCAGGCCCCACC	0.542													27	81					0	0	0	0	T	12835020	T	T	12835020	4	4	36	1	0	0	0	0	0	1	0	0	12488	595	21	4	12	4	PRAMEF12	1	12835020	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	108275	12835020	236415601	5	6805											
PRAMEF1	65121	broad.mit.edu	37	chr1	12855732	12855732	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgttccgcatcagtcttGaacccctcggagctctgctg	5	12	10	14	2	3	1	1	1	2	0	5	2	4	2	3	1	4	5	3	1	1	2	rs139798913		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:12855732G>A	uc001auj.1	+	4	1115	c.1012G>A	c.(1012-1014)GAA>AAA	p.E338K		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	338	LRR 1.										0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CATCAGTCTTGAACCCCTCGG	0.522													81	267					0	0	0	0	A	12855732	A	A	12855732	3	1	36	1	0	0	0	0	1	0	0	0	12485	1291	45	2	1022	2	PRAMEF1	1	12855732	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	20712	12855732	236394889	6	6806											
PRAMEF11	440560	broad.mit.edu	37	chr1	12884942	12884942	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagccctaatttgagcaaatCtgctccagcagagagtacca	13	8	8	12	0	1	2	0	1	1	1	2	3	2	2	3	0	5	4	3	0	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:12884942C>G	uc001auk.2	-	4	1365	c.1169G>C	c.(1168-1170)AGA>ACA	p.R390T		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	390											0						TTGAGCAAATCTGCTCCAGCA	0.498													106	306					0	0	0	0	G	12884942	G	G	12884942	3	3	36	1	0	0	0	0	1	0	0	0	12487	913	32	2	145	2	PRAMEF11	1	12884942	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	29210	12884942	236365679	7	6807											
LOC649330	649330	broad.mit.edu	37	chr1	12908067	12908067	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccgatttcttgacaacaaGagtgttgagattcccaatga	13	12	8	8	1	1	4	0	3	1	2	3	6	3	4	2	0	1	1	2	0	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:12908067G>C	uc009vno.2	-	1	171	c.76C>G	c.(76-78)CTT>GTT	p.L26V	HNRNPCL1_uc010obf.1_Missense_Mutation_p.L26V	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	26							nucleic acid binding|nucleotide binding				0						TTGACAACAAGAGTGTTGAGA	0.443													32	303					0	0	0	0	C	12908067	C	C	12908067	3	2	36	1	0	0	0	0	1	0	0	0	8935	942	33	2	809	2	LOC649330	1	12908067	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	23125	12908067	236342554	8	6808											
HSPB7	27129	broad.mit.edu	37	chr1	16344280	16344280	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgggaaggccaggggctccGagtggggccgcatgaagctg	7	5	19	10	2	0	1	0	1	0	0	1	3	1	2	3	6	1	3	3	6	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:16344280G>A	uc001axo.2	-	1	1006	c.179C>T	c.(178-180)TCG>TTG	p.S60L	HSPB7_uc001axp.2_Missense_Mutation_p.S148L|HSPB7_uc001axq.2_Missense_Mutation_p.S148L|HSPB7_uc001axr.2_Missense_Mutation_p.S148L|HSPB7_uc001axs.2_Missense_Mutation_p.S135L|CLCNKA_uc001axt.2_5'Flank	NM_014424	NP_055239	Q9UBY9	HSPB7_HUMAN	cardiovascular heat shock protein	60	Required for localization to SC35 splicing speckles.				regulation of heart contraction|response to heat|response to unfolded protein	Cajal body	protein C-terminus binding				0		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.21e-08)|COAD - Colon adenocarcinoma(227;5.5e-06)|BRCA - Breast invasive adenocarcinoma(304;9.08e-05)|Kidney(64;0.000162)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00656)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGGGCTCCGAGTGGGGCCG	0.662													11	19					0	0	0	0	A	16344280	A	A	16344280	3	1	36	1	0	0	0	0	1	0	0	0	7461	1059	37	1	345	1	HSPB7	1	16344280	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3436213	16344280	232906341	9	6809											
ARHGEF10L	55160	broad.mit.edu	37	chr1	17961342	17961342	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaacaggggccagctggaGatcagcagcctggtgcccct	8	6	13	14	0	1	1	1	0	0	1	2	2	2	1	5	4	5	2	5	4	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:17961342G>C	uc001ban.2	+	18	1917	c.1758G>C	c.(1756-1758)GAG>GAC	p.E586D	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.E547D|ARHGEF10L_uc001bao.2_Missense_Mutation_p.E547D|ARHGEF10L_uc001bap.2_Missense_Mutation_p.E542D|ARHGEF10L_uc010ocr.1_Missense_Mutation_p.E344D|ARHGEF10L_uc001baq.2_Missense_Mutation_p.E347D|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.E359D|ARHGEF10L_uc001bar.2_Missense_Mutation_p.E289D|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	586					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GCCAGCTGGAGATCAGCAGCC	0.672													11	21					0	0	0	0	C	17961342	C	C	17961342	3	2	36	1	0	0	0	0	1	0	0	0	895	933	33	2	1824	2	ARHGEF10L	1	17961342	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1617062	17961342	231289279	10	6810											
KIF17	57576	broad.mit.edu	37	chr1	21031010	21031010	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatctcctcctggtactcGcgaagcagcgcatccttggg	6	11	11	13	3	1	1	0	1	1	0	5	2	3	1	3	2	3	3	3	2	2	3	rs76507805	by1000genomes	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:21031010G>A	uc001bdr.3	-	5	1171	c.1053C>T	c.(1051-1053)CGC>CGT	p.R351R	KIF17_uc001bds.3_Silent_p.R351R	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	351	Potential.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CCTGGTACTCGCGAAGCAGCG	0.602													15	65					0	0	0	0	A	21031010	A	A	21031010	2	1	36	1	0	0	0	0	0	0	0	1	8318	1074	38	1		1	KIF17	1	21031010	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3069668	21031010	228219611	11	6811											
CELA3A	10136	broad.mit.edu	37	chr1	22329569	22329569	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggatgcggtcccctacagCtggccctggcaggtaagagc	8	6	15	12	1	0	1	0	0	0	1	1	3	1	2	3	5	4	3	3	5	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:22329569C>T	uc001bfl.2	+	2	136	c.117C>T	c.(115-117)AGC>AGT	p.S39S	CELA3B_uc009vqf.2_Intron	NM_005747	NP_005738	P09093	CEL3A_HUMAN	elastase 3A, pancreatic preproprotein	39	Peptidase S1.				cholesterol metabolic process|digestion|proteolysis		serine-type endopeptidase activity			haematopoietic_and_lymphoid_tissue(1)	1						TCCCCTACAGCTGGCCCTGGC	0.597													22	121					0	0	0	0	T	22329569	T	T	22329569	2	4	36	1	0	0	0	0	0	0	0	1	3228	796	28	4		4	CELA3A	1	22329569	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1298559	22329569	226921052	12	6812											
HNRNPR	10236	broad.mit.edu	37	chr1	23637048	23637048	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accttgctgaagcggctgctGagcgatgggttgggaacccc	7	8	15	11	2	0	2	0	2	0	0	0	4	0	3	3	3	5	4	3	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:23637048G>C	uc001bgr.3	-	11	1960	c.1801C>G	c.(1801-1803)CAG>GAG	p.Q601E	HNRNPR_uc001bgo.2_Missense_Mutation_p.Q211E|HNRNPR_uc001bgp.3_Missense_Mutation_p.Q604E|HNRNPR_uc009vqk.2_Missense_Mutation_p.Q503E|HNRNPR_uc001bgs.3_Missense_Mutation_p.Q500E|HNRNPR_uc010odw.1_Missense_Mutation_p.Q563E|HNRNPR_uc010odx.1_Missense_Mutation_p.Q441E|HNRNPR_uc009vql.2_Missense_Mutation_p.Q462E	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	601	Asn/Gln-rich.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		AGCGGCTGCTGAGCGATGGGT	0.478													71	247					0	0	0	0	C	23637048	C	C	23637048	3	2	36	1	0	0	0	0	1	0	0	0	7311	1299	45	2	104	2	HNRNPR	1	23637048	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1307479	23637048	225613573	13	6813											
SRRM1	10250	broad.mit.edu	37	chr1	24995948	24995948	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccacggcctcgagctcctCagacctcctcaagtcctcca	8	7	6	20	2	2	1	2	0	0	1	7	2	6	1	7	1	1	1	7	1	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:24995948C>G	uc001bjm.2	+	14	2298	c.2074C>G	c.(2074-2076)CAG>GAG	p.Q692E	SRRM1_uc010oel.1_Missense_Mutation_p.Q704E|SRRM1_uc009vrh.1_Missense_Mutation_p.Q665E|SRRM1_uc009vri.1_Missense_Mutation_p.Q621E	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	692	Pro-rich.|Arg-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		TCGAGCTCCTCAGACCTCCTC	0.592													11	34					0	0	0	0	G	24995948	G	G	24995948	3	3	36	1	0	0	0	0	1	0	0	0	15234	827	29	2	2128	2	SRRM1	1	24995948	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1358900	24995948	224254673	14	6814											
ZNF683	257101	broad.mit.edu	37	chr1	26688267	26688267	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcatagcccatgtgtttctCagatgccaccgccataagat	10	11	8	12	1	2	2	2	0	1	2	3	2	2	2	4	0	2	1	4	0	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:26688267C>G	uc001bmg.1	-	7	1568	c.1450G>C	c.(1450-1452)GAG>CAG	p.E484Q	ZNF683_uc001bmh.1_Missense_Mutation_p.E464Q|ZNF683_uc009vsj.1_Missense_Mutation_p.E464Q	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	484					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		ATGTGTTTCTCAGATGCCACC	0.602													35	127					0	0	0	0	G	26688267	G	G	26688267	3	3	36	1	0	0	0	0	1	0	0	0	18157	835	29	2	128	2	ZNF683	1	26688267	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1692319	26688267	222562354	15	6815											
ARID1A	8289	broad.mit.edu	37	chr1	27101074	27101074	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaccagcaggcggcccccaGaaccaatttccattccagtt	10	7	8	16	2	0	1	0	0	0	1	2	2	2	1	6	2	2	2	6	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:27101074G>C	uc001bmv.1	+	18	4729	c.4356G>C	c.(4354-4356)CAG>CAC	p.Q1452H	ARID1A_uc001bmt.1_Missense_Mutation_p.Q1451H|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Missense_Mutation_p.Q1069H|ARID1A_uc001bmx.1_Missense_Mutation_p.Q298H|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1452					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCGGCCCCCAGAACCAATTTC	0.587			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								4	159					0	0	0	0	C	27101074	C	C	27101074	3	2	36	1	0	0	0	0	1	0	0	0	913	933	33	2	4426	2	ARID1A	1	27101074	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	412807	27101074	222149547	16	6816											
ARID1A	8289	broad.mit.edu	37	chr1	27101465	27101465	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caagcatgcagaatcacattCctcaggtatccagccctgct	11	9	7	14	0	2	1	2	0	0	1	4	1	4	1	3	1	4	4	3	1	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:27101465C>T	uc001bmv.1	+	18	5120	c.4747C>T	c.(4747-4749)CCT>TCT	p.P1583S	ARID1A_uc001bmt.1_Missense_Mutation_p.P1582S|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Missense_Mutation_p.P1200S|ARID1A_uc001bmx.1_Missense_Mutation_p.P429S|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1583					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GAATCACATTCCTCAGGTATC	0.602			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								40	75					0	0	0	0	T	27101465	T	T	27101465	3	4	36	1	0	0	0	0	1	0	0	0	913	855	30	2	4817	2	ARID1A	1	27101465	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	391	27101465	222149156	17	6817											
PHACTR4	65979	broad.mit.edu	37	chr1	28806962	28806962	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttcttccccgtgtgcaaaGgtgctctcgccaacaaagtg	8	12	9	12	2	2	0	0	0	2	0	4	0	3	0	3	1	3	2	3	1	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:28806962G>A	uc001bpw.2	+	9	1889	c.1607_splice	c.e9-1	p.S536_splice	PHACTR4_uc001bpv.1_Splice_Site|PHACTR4_uc001bpx.2_Splice_Site_p.S520_splice|PHACTR4_uc001bpy.2_Splice_Site_p.S546_splice	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1								actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		CGTGTGCAAAGGTGCTCTCGC	0.428													20	88					0	0	0	0	A	28806962	A	A	28806962	5	1	36	1	0	0	0	0	0	0	1	0	11867	1014	35	4	1686	4	PHACTR4	1	28806962	Splice_Site	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1705497	28806962	220443659	18	6818											
PHACTR4	65979	broad.mit.edu	37	chr1	28807096	28807096	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaatgaaatacggcaccaGattggaaacacactgatccg	15	7	10	9	2	0	3	0	2	0	1	1	5	1	5	2	3	2	1	2	3	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:28807096G>C	uc001bpw.2	+	9	2022	c.1740G>C	c.(1738-1740)CAG>CAC	p.Q580H	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.Q564H|PHACTR4_uc001bpy.2_Missense_Mutation_p.Q590H	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	580							actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TACGGCACCAGATTGGAAACA	0.418													47	211					0	0	0	0	C	28807096	C	C	28807096	3	2	36	1	0	0	0	0	1	0	0	0	11867	933	33	2	1820	2	PHACTR4	1	28807096	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	134	28807096	220443525	19	6819											
C1orf94	84970	broad.mit.edu	37	chr1	34667794	34667794	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaaccctgaaccagccactCtggctcaacctgaactatcc	11	7	6	17	0	2	2	1	2	1	0	3	2	3	2	5	1	5	2	5	1	5	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:34667794C>G	uc001bxs.3	+	4	1209	c.810C>G	c.(808-810)CTC>CTG	p.L270L	C1orf94_uc001bxt.2_Silent_p.L460L	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	270							protein binding				0		Myeloproliferative disorder(586;0.0393)				ACCAGCCACTCTGGCTCAACC	0.522													19	55					0	0	0	0	G	34667794	G	G	34667794	2	3	36	1	0	0	0	0	0	0	0	1	2081	900	32	2		2	C1orf94	1	34667794	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5860698	34667794	214582827	20	6820											
CLSPN	63967	broad.mit.edu	37	chr1	36230196	36230196	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attctctttattttcctcctCggcactgtcataggtagttt	6	19	6	10	1	2	0	1	0	1	0	6	0	4	0	2	2	0	3	2	2	3	8	rs139161179	byFrequency	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:36230196C>T	uc001bzi.2	-	3	333	c.253G>A	c.(253-255)GAG>AAG	p.E85K	CLSPN_uc009vux.2_Missense_Mutation_p.E85K	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	85					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTTTCCTCCTCGGCACTGTCA	0.373													23	160					0	0	0	0	T	36230196	T	T	36230196	3	4	36	1	0	0	0	0	1	0	0	0	3575	893	31	1	3858	1	CLSPN	1	36230196	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1562402	36230196	213020425	21	6821											
EIF2C3	192669	broad.mit.edu	37	chr1	36521242	36521242	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccacttctcttacagtgctGaaggaagtcacgtttcagga	10	11	10	10	1	3	1	2	1	1	0	4	3	3	3	1	2	2	2	1	2	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:36521242G>A	uc001bzp.2	+	19	2735	c.2479G>A	c.(2479-2481)GAA>AAA	p.E827K	EIF2C3_uc001bzq.2_Missense_Mutation_p.E593K	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	827					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTACAGTGCTGAAGGAAGTCA	0.373													10	212					0	0	0	0	A	36521242	A	A	36521242	3	1	36	1	0	0	0	0	1	0	0	0	5029	1291	45	2	2553	2	EIF2C3	1	36521242	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	291046	36521242	212729379	22	6822											
SF3A3	10946	broad.mit.edu	37	chr1	38449853	38449853	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccttacctcagatgccttCaggttaatgtacttgaggta	9	13	10	9	0	2	2	2	1	0	1	2	2	2	2	3	3	3	3	3	3	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:38449853C>T	uc001cci.2	-	6	580	c.456G>A	c.(454-456)CTG>CTA	p.L152L	SF3A3_uc010oik.1_Silent_p.L99L	NM_006802	NP_006793	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3	152					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CAGATGCCTTCAGGTTAATGT	0.468													9	42					0	0	0	0	T	38449853	T	T	38449853	2	4	36	1	0	0	0	0	0	0	0	1	14213	813	29	2		2	SF3A3	1	38449853	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1928611	38449853	210800768	23	6823											
MACF1	23499	broad.mit.edu	37	chr1	39792905	39792905	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaggctctcagaaaaagaGaagaaacaaatatctgagca	19	6	8	8	0	2	4	1	1	2	3	4	5	3	4	1	1	2	2	1	1	6	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:39792905G>A	uc010ois.1	+	37	4714	c.4509G>A	c.(4507-4509)GAG>GAA	p.E1503E	MACF1_uc001cda.1_Silent_p.E1411E|MACF1_uc001cdc.1_Silent_p.E590E|MACF1_uc001cdb.1_Silent_p.E590E	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGAAAAAGAGAAGAAACAAA	0.388													13	74					0	0	0	0	A	39792905	A	A	39792905	2	1	36	1	0	0	0	0	0	0	0	1	9195	933	33	2		2	MACF1	1	39792905	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1343052	39792905	209457716	24	6824											
MACF1	23499	broad.mit.edu	37	chr1	39806314	39806314	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagatgccaagaatcttcaGaagtctctcagctctgtgag	13	10	9	9	0	5	4	2	1	3	3	6	4	5	4	1	0	2	1	1	0	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:39806314G>C	uc010oiu.1	+	3	5807	c.5676G>C	c.(5674-5676)CAG>CAC	p.Q1892H	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3457					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAATCTTCAGAAGTCTCTCA	0.433													17	70					0	0	0	0	C	39806314	C	C	39806314	3	2	36	1	0	0	0	0	1	0	0	0	9195	933	33	2	10455	2	MACF1	1	39806314	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	13409	39806314	209444307	25	6825											
MACF1	23499	broad.mit.edu	37	chr1	39833972	39833972	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttcacagagctacagaaGacagttaaagagaggtgagt	16	7	12	6	0	1	5	1	1	0	4	1	7	1	5	0	1	2	2	0	1	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:39833972G>C	uc010oiu.1	+	14	8375	c.8244G>C	c.(8242-8244)AAG>AAC	p.K2748N	MACF1_uc010ois.1_Missense_Mutation_p.K2246N|MACF1_uc001cda.1_Missense_Mutation_p.K2154N|MACF1_uc001cdc.1_Missense_Mutation_p.K1333N|MACF1_uc001cdb.1_Missense_Mutation_p.K1333N	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4313					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGCTACAGAAGACAGTTAAAG	0.423													30	116					0	0	0	0	C	39833972	C	C	39833972	3	2	36	1	0	0	0	0	1	0	0	0	9195	933	33	2	13067	2	MACF1	1	39833972	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	27658	39833972	209416649	26	6826											
TRIT1	54802	broad.mit.edu	37	chr1	40313713	40313713	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgaaaatctcttagttcctCcaagagcccagcagcaagca	13	8	8	12	0	1	2	0	1	1	1	4	2	3	2	3	0	4	4	3	0	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:40313713C>T	uc010oiz.1	-	6	774	c.760G>A	c.(760-762)GAG>AAG	p.E254K	TRIT1_uc001cec.3_RNA|TRIT1_uc001ced.3_5'UTR|TRIT1_uc001cee.3_RNA|TRIT1_uc001cef.3_RNA|TRIT1_uc001ceg.3_Missense_Mutation_p.E8K|TRIT1_uc001ceh.3_Missense_Mutation_p.E8K|TRIT1_uc009vvv.2_Missense_Mutation_p.E113K|TRIT1_uc001cei.3_Missense_Mutation_p.E8K|TRIT1_uc001ceq.2_5'UTR|TRIT1_uc001cek.2_5'UTR|TRIT1_uc009vvx.2_Intron|TRIT1_uc001cel.2_Intron|TRIT1_uc001cem.2_Missense_Mutation_p.E172K|TRIT1_uc001cen.2_Missense_Mutation_p.E8K|TRIT1_uc001ceo.2_Missense_Mutation_p.E8K|TRIT1_uc001cep.2_Missense_Mutation_p.E8K	NM_017646	NP_060116	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1 precursor	254	Interaction with isopentenylpyrophosphate transferase (By similarity).				tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CTTAGTTCCTCCAAGAGCCCA	0.428													35	137					0	0	0	0	T	40313713	T	T	40313713	3	4	36	1	0	0	0	0	1	0	0	0	16627	864	30	2	667	2	TRIT1	1	40313713	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	479741	40313713	208936908	27	6827											
RLF	6018	broad.mit.edu	37	chr1	40703619	40703619	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataacacatggatctttctCagggtcattgcaggggtacc	11	11	10	9	0	3	0	2	0	2	0	4	1	3	1	1	4	3	2	1	4	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:40703619C>G	uc001cfc.3	+	8	3276	c.3245C>G	c.(3244-3246)TCA>TGA	p.S1082*	RLF_uc001cfd.3_Nonsense_Mutation_p.S773*	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1082					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			GGATCTTTCTCAGGGTCATTG	0.408													47	186					0	0	0	0	G	40703619	G	G	40703619	4	3	36	1	0	0	0	0	0	1	0	0	13454	838	29	2	3275	2	RLF	1	40703619	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	389906	40703619	208547002	28	6828											
ZNF684	127396	broad.mit.edu	37	chr1	41012566	41012566	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaaccttttgaatgcaatGactgtggaaaagcctatagc	16	10	8	7	0	0	2	0	2	0	0	0	3	0	3	2	1	4	1	2	1	8	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:41012566G>A	uc001cft.1	+	5	822	c.571G>A	c.(571-573)GAC>AAC	p.D191N		NM_152373	NP_689586	Q5T5D7	ZN684_HUMAN	zinc finger protein 684	191	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			TGAATGCAATGACTGTGGAAA	0.393													17	118					0	0	0	0	A	41012566	A	A	41012566	3	1	36	1	0	0	0	0	1	0	0	0	18158	1290	45	2	585	2	ZNF684	1	41012566	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	308947	41012566	208238055	29	6829											
EDN2	1907	broad.mit.edu	37	chr1	41946860	41946860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttgggactgccccggcttCagtcctacgtgaatagcatt	7	11	11	12	2	1	1	1	1	0	0	2	2	2	2	3	2	3	3	3	2	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:41946860C>G	uc001cgx.2	-	4	421	c.349G>C	c.(349-351)GAA>CAA	p.E117Q	EDN2_uc001cgu.2_Intron|EDN2_uc001cgv.2_RNA|EDN2_uc009vwh.2_5'UTR|EDN2_uc001cgw.2_Intron|EDN2_uc009vwi.2_RNA|EDN2_uc009vwj.2_Intron	NM_001956	NP_001947	P20800	EDN2_HUMAN	endothelin 2 preproprotein	117					artery smooth muscle contraction|calcium-mediated signaling|cytokine-mediated signaling pathway|elevation of cytosolic calcium ion concentration|hormonal regulation of the force of heart contraction|inositol phosphate-mediated signaling|macrophage activation|macrophage chemotaxis|neutrophil chemotaxis|positive regulation of cell proliferation|positive regulation of heart rate|positive regulation of leukocyte chemotaxis|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of the force of heart contraction by chemical signal|prostaglandin biosynthetic process|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space	endothelin B receptor binding|hormone activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCCCCGGCTTCAGTCCTACGT	0.632													35	95					0	0	0	0	G	41946860	G	G	41946860	3	3	36	1	0	0	0	0	1	0	0	0	4939	835	29	2	195	2	EDN2	1	41946860	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	934294	41946860	207303761	30	6830											
EBNA1BP2	10969	broad.mit.edu	37	chr1	43636430	43636430	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaacttctatttcttaccttCtgcatctgcagatcagattt	10	17	4	10	0	5	2	1	0	4	2	5	2	5	2	1	0	4	2	1	0	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:43636430C>T	uc001cin.2	-	4	641	c.444G>A	c.(442-444)CAG>CAA	p.Q148Q	EBNA1BP2_uc001cio.2_Silent_p.Q203Q|WDR65_uc010ojz.1_5'Flank|WDR65_uc001cip.1_5'Flank|WDR65_uc001ciq.1_5'Flank|EBNA1BP2_uc001cim.2_Silent_p.Q43Q|EBNA1BP2_uc010ojx.1_Silent_p.Q203Q	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	148	Potential.				ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTCTTACCTTCTGCATCTGCA	0.453													77	308					0	0	0	0	T	43636430	T	T	43636430	2	4	36	1	0	0	0	0	0	0	0	1	4907	912	32	2		2	EBNA1BP2	1	43636430	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1689570	43636430	205614191	31	6831											
KIAA0467	23334	broad.mit.edu	37	chr1	43907221	43907221	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgaggtggggacccttcatCctgtgtttgcccgtgttgct	3	14	14	10	1	1	1	1	1	0	0	2	2	2	2	3	3	2	3	3	3	0	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:43907221C>T	uc001cjk.1	+	39	5323	c.4861C>T	c.(4861-4863)CCT>TCT	p.P1621S		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2520						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GACCCTTCATCCTGTGTTTGC	0.552													96	381					0	0	0	0	T	43907221	T	T	43907221	3	4	36	1	0	0	0	0	1	0	0	0	8217	855	30	2	5007	2	KIAA0467	1	43907221	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	270791	43907221	205343400	32	6832											
KIAA0467	23334	broad.mit.edu	37	chr1	43908875	43908875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagagctggagcgccagatGaagatggaaaacctgtttgt	12	9	13	7	1	1	4	1	1	0	3	1	6	1	6	2	2	3	2	2	2	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:43908875G>A	uc001cjk.1	+	45	6201	c.5739G>A	c.(5737-5739)ATG>ATA	p.M1913I		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2812						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGCGCCAGATGAAGATGGAAA	0.552													27	88					0	0	0	0	A	43908875	A	A	43908875	3	1	36	1	0	0	0	0	1	0	0	0	8217	1290	45	2	5909	2	KIAA0467	1	43908875	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1654	43908875	205341746	33	6833											
B4GALT2	8704	broad.mit.edu	37	chr1	44456112	44456112	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcctccgtcgtggccccctCggggctgacactaatggaca	6	7	13	15	3	0	1	0	1	0	0	3	2	1	2	4	5	0	1	4	5	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:44456112C>T	uc001clg.2	+	7	1481	c.1111C>T	c.(1111-1113)CGG>TGG	p.R371W	B4GALT2_uc001clh.2_Missense_Mutation_p.R305W|B4GALT2_uc010okl.1_Missense_Mutation_p.R400W|B4GALT2_uc001cli.2_Missense_Mutation_p.R371W|CCDC24_uc001clj.2_5'Flank|CCDC24_uc001clk.2_5'Flank|CCDC24_uc009vxc.2_5'Flank	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	371	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	GTGGCCCCCTCGGGGCTGACA	0.622													14	274					0	0	0	0	T	44456112	T	T	44456112	3	4	36	1	0	0	0	0	1	0	0	0	1273	875	31	1	1133	1	B4GALT2	1	44456112	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	547237	44456112	204794509	34	6834											
CC2D1B	200014	broad.mit.edu	37	chr1	52821958	52821958	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctgtttcttgcggtcctGagcaagcttctcaaatctga	8	13	9	11	1	3	2	1	2	3	0	5	2	4	2	1	1	4	4	1	1	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:52821958G>C	uc001ctq.1	-	18	2110	c.1972C>G	c.(1972-1974)CAG>GAG	p.Q658E	CC2D1B_uc001ctr.2_Missense_Mutation_p.Q198E|CC2D1B_uc001cts.2_Missense_Mutation_p.Q343E	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	658										ovary(2)	2						TTGCGGTCCTGAGCAAGCTTC	0.572													64	299					0	0	0	0	C	52821958	C	C	52821958	3	2	36	1	0	0	0	0	1	0	0	0	2739	1299	45	2	632	2	CC2D1B	1	52821958	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	8365846	52821958	196428663	35	6835											
ZCCHC11	23318	broad.mit.edu	37	chr1	52981631	52981631	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcaaccccagcctctgctCaggtgtcaatgcagattcat	9	12	7	13	0	5	1	4	0	1	1	5	1	5	1	3	1	4	2	3	1	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:52981631C>G	uc001ctx.2	-	3	1048	c.814G>C	c.(814-816)GAG>CAG	p.E272Q	ZCCHC11_uc001cty.2_Missense_Mutation_p.E272Q|ZCCHC11_uc001ctz.2_Missense_Mutation_p.E272Q|ZCCHC11_uc009vze.1_Missense_Mutation_p.E272Q|ZCCHC11_uc009vzf.1_Missense_Mutation_p.E31Q|ZCCHC11_uc001cub.2_Missense_Mutation_p.E272Q|ZCCHC11_uc001cuc.2_RNA|ZCCHC11_uc001cud.2_Missense_Mutation_p.E272Q	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	272					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						AGCCTCTGCTCAGGTGTCAAT	0.368													40	159					0	0	0	0	G	52981631	G	G	52981631	3	3	36	1	0	0	0	0	1	0	0	0	17647	835	29	2	4235	2	ZCCHC11	1	52981631	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	159673	52981631	196268990	36	6836											
ECHDC2	55268	broad.mit.edu	37	chr1	53373583	53373583	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcgctggacaaacaccccCacctctgcttcactcatctg	9	9	6	17	1	4	0	2	0	2	0	5	1	4	1	3	1	2	2	3	1	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:53373583C>G	uc001cup.3	-	4	567	c.321G>C	c.(319-321)GTG>GTC	p.V107V	ECHDC2_uc001cun.2_Silent_p.V61V|ECHDC2_uc001cuo.3_Silent_p.V107V|ECHDC2_uc010onk.1_Silent_p.V61V|ECHDC2_uc010onl.1_Silent_p.V61V|ECHDC2_uc010onm.1_Silent_p.V61V|ECHDC2_uc010onn.1_Silent_p.V61V	NM_018281	NP_060751	Q86YB7	ECHD2_HUMAN	enoyl Coenzyme A hydratase domain containing 2	107					fatty acid metabolic process	mitochondrion	lyase activity			central_nervous_system(1)	1						CAAACACCCCCACCTCTGCTT	0.592													13	103					0	0	0	0	G	53373583	G	G	53373583	2	3	36	1	0	0	0	0	0	0	0	1	4916	581	21	4		4	ECHDC2	1	53373583	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	391952	53373583	195877038	37	6837											
TMEM48	55706	broad.mit.edu	37	chr1	54269611	54269611	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagcaatacctggttggctGaggctgaaaacttcttgtct	9	14	10	8	0	2	2	0	2	2	0	2	2	2	2	1	3	3	4	1	3	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:54269611G>C	uc001cvs.2	-	10	1297	c.1056C>G	c.(1054-1056)CTC>CTG	p.L352L	TMEM48_uc010onu.1_Silent_p.L312L|TMEM48_uc001cvt.2_Silent_p.L229L|TMEM48_uc009vzk.2_RNA|TMEM48_uc010onv.1_Silent_p.L17L	NM_018087	NP_060557	Q9BTX1	NDC1_HUMAN	transmembrane protein 48	352	Cytoplasmic (Potential).				mRNA transport|nuclear pore complex assembly|nuclear pore distribution|protein transport|transmembrane transport	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore			ovary(1)|pancreas(1)	2						CTGGTTGGCTGAGGCTGAAAA	0.308													98	424					0	0	0	0	C	54269611	C	C	54269611	2	2	36	1	0	0	0	0	0	0	0	1	16238	1277	45	2		2	TMEM48	1	54269611	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	896028	54269611	194981010	38	6838											
FAM151A	338094	broad.mit.edu	37	chr1	55089033	55089033	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgccggcaaacacccacttGacctgattctttgataactg	11	11	7	12	1	1	3	0	3	1	0	1	3	1	3	3	1	3	1	3	1	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:55089033G>C	uc001cxn.2	-	1	168	c.36C>G	c.(34-36)GTC>GTG	p.V12V	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	12						integral to membrane					0						ACACCCACTTGACCTGATTCT	0.612													53	233					0	0	0	0	C	55089033	C	C	55089033	2	2	36	1	0	0	0	0	0	0	0	1	5486	1277	45	2		2	FAM151A	1	55089033	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	819422	55089033	194161588	39	6839											
C1orf175	374977	broad.mit.edu	37	chr1	55130890	55130890	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaggtgccagagaagacaGaaggtggcaacaacatggct	15	5	14	7	0	0	4	0	1	0	3	0	5	0	4	1	4	3	2	1	4	5	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:55130890G>C	uc010ooe.1	+	4	1606	c.1282G>C	c.(1282-1284)GAA>CAA	p.E428Q	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_5'UTR|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_5'UTR|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.E428Q|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	428						integral to membrane	binding				0						AGAGAAGACAGAAGGTGGCAA	0.552													9	82					0	0	0	0	C	55130890	C	C	55130890	3	2	36	1	0	0	0	0	1	0	0	0	2025	943	33	2	1288	2	C1orf175	1	55130890	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	41857	55130890	194119731	40	6840											
C1orf168	199920	broad.mit.edu	37	chr1	57257831	57257831	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagctttttctgatatgttGagaaattacaaaagagggat	14	13	9	5	0	1	3	0	2	1	2	1	5	1	4	1	1	2	2	1	1	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:57257831G>C	uc001cym.3	-	2	1061	c.655C>G	c.(655-657)CAA>GAA	p.Q219E	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Missense_Mutation_p.Q219E	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	219										ovary(3)|skin(2)	5						CTGATATGTTGAGAAATTACA	0.522													50	279					0	0	0	0	C	57257831	C	C	57257831	3	2	36	1	0	0	0	0	1	0	0	0	2021	1299	45	2	1607	2	C1orf168	1	57257831	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2126941	57257831	191992790	41	6841											
INADL	10207	broad.mit.edu	37	chr1	62455875	62455875	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatgcagatctgcctggaGaactgcacattattgaactt	12	12	9	8	0	1	3	0	1	1	2	1	5	1	3	1	1	5	2	1	1	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:62455875G>C	uc001dab.2	+	28	3820	c.3706G>C	c.(3706-3708)GAA>CAA	p.E1236Q	INADL_uc009waf.1_Missense_Mutation_p.E1236Q|INADL_uc001daa.2_Missense_Mutation_p.E1236Q|INADL_uc001dad.3_Missense_Mutation_p.E933Q|INADL_uc001dac.2_RNA|INADL_uc010oot.1_Missense_Mutation_p.E20Q|INADL_uc009wag.2_Missense_Mutation_p.E20Q|INADL_uc010oou.1_5'UTR	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1236					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						TCTGCCTGGAGAACTGCACAT	0.333													17	90					0	0	0	0	C	62455875	C	C	62455875	3	2	36	1	0	0	0	0	1	0	0	0	7770	943	33	2	3812	2	INADL	1	62455875	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5198044	62455875	186794746	42	6842											
PDE4B	5142	broad.mit.edu	37	chr1	66838008	66838008	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctccaggttggtttcatcGactacattgtccatccattg	7	16	7	11	1	2	0	1	0	1	0	6	1	4	0	3	2	1	2	3	2	1	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:66838008G>A	uc001dcn.2	+	17	2049	c.1858G>A	c.(1858-1860)GAC>AAC	p.D620N	PDE4B_uc009war.2_Missense_Mutation_p.D528N|PDE4B_uc001dco.2_Missense_Mutation_p.D620N|PDE4B_uc001dcp.2_Missense_Mutation_p.D605N|PDE4B_uc001dcq.2_Missense_Mutation_p.D448N|PDE4B_uc009was.2_Missense_Mutation_p.D387N	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	620					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	TGGTTTCATCGACTACATTGT	0.413													56	164					0	0	0	0	A	66838008	A	A	66838008	3	1	36	1	0	0	0	0	1	0	0	0	11694	1058	37	1	2278	1	PDE4B	1	66838008	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4382133	66838008	182412613	43	6843											
WDR78	79819	broad.mit.edu	37	chr1	67340502	67340502	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagattctacagagaccatGactgtgggcaagtcaaaaaa	16	8	9	8	0	3	3	2	1	1	2	3	4	3	3	1	1	1	1	1	1	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:67340502G>A	uc001dcx.2	-	5	818	c.762C>T	c.(760-762)GTC>GTT	p.V254V	WDR78_uc001dcy.2_Silent_p.V254V|WDR78_uc001dcz.2_Silent_p.V254V|WDR78_uc009waw.2_5'UTR|WDR78_uc009wax.2_Intron	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	254										ovary(2)	2						CAGAGACCATGACTGTGGGCA	0.373													49	151					0	0	0	0	A	67340502	A	A	67340502	2	1	36	1	0	0	0	0	0	0	0	1	17396	1277	45	2		2	WDR78	1	67340502	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	502494	67340502	181910119	44	6844											
RPE65	6121	broad.mit.edu	37	chr1	68897200	68897200	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaggctccagccagatagtCtcgtcactgcacagaattgc	10	9	9	13	1	3	2	2	0	1	2	5	2	4	2	2	1	3	2	2	1	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:68897200C>T	uc001dei.1	-	11	1251	c.1197G>A	c.(1195-1197)GAG>GAA	p.E399E		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	399					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						GCCAGATAGTCTCGTCACTGC	0.463													25	42					0	0	0	0	T	68897200	T	T	68897200	2	4	36	1	0	0	0	0	0	0	0	1	13610	912	32	2		2	RPE65	1	68897200	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1556698	68897200	180353421	45	6845											
LRRC8D	55144	broad.mit.edu	37	chr1	90401042	90401042	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctcactcagctggagctGaaggggaactgcttggaccg	9	7	14	11	1	2	1	2	1	0	0	2	4	2	4	1	4	5	4	1	4	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:90401042G>A	uc001dnm.2	+	3	2840	c.2415G>A	c.(2413-2415)CTG>CTA	p.L805L	LRRC8D_uc001dnn.2_Silent_p.L805L	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	805	LRR 13.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		AGCTGGAGCTGAAGGGGAACT	0.527													37	64					0	0	0	0	A	90401042	A	A	90401042	2	1	36	1	0	0	0	0	0	0	0	1	9074	1277	45	2		2	LRRC8D	1	90401042	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	21503842	90401042	158849579	46	6846											
FRRS1	391059	broad.mit.edu	37	chr1	100203724	100203724	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatcaccgattggtcatctCttgtgaaggacaagaagaca	13	9	9	10	1	3	3	2	1	1	2	4	5	3	4	2	2	0	0	2	2	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:100203724C>G	uc001dsh.1	-	7	1279	c.677G>C	c.(676-678)AGA>ACA	p.R226T		NM_001013660	NP_001013682	Q6ZNA5	FRRS1_HUMAN	stromal cell derived factor receptor 2 homolog	226	DOMON.				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		TTGGTCATCTCTTGTGAAGGA	0.458													11	127					0	0	0	0	G	100203724	G	G	100203724	3	3	36	1	0	0	0	0	1	0	0	0	6094	913	32	2	1247	2	FRRS1	1	100203724	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	9802682	100203724	149046897	47	6847											
CELSR2	1952	broad.mit.edu	37	chr1	109806290	109806290	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggtggcctggcatggcctctCgctgcccatctcccaaccct	4	9	10	18	1	2	0	0	0	2	0	4	0	2	0	5	4	2	2	5	4	1	0	rs139381040		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:109806290C>G	uc001dxa.3	+	9	4953	c.4892C>G	c.(4891-4893)TCG>TGG	p.S1631W		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1631	Extracellular (Potential).|Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CATGGCCTCTCGCTGCCCATC	0.652											OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	124					0	0	0	0	G	109806290	G	G	109806290	3	3	36	1	0	0	0	0	1	0	0	0	3237	893	31	3	4926	3	CELSR2	1	109806290	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	9602566	109806290	139444331	48	6848											
CTTNBP2NL	55917	broad.mit.edu	37	chr1	113000008	113000008	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagcaaatggtaaggatgttGagttacttttgcctaccagc	11	13	10	7	0	0	1	0	1	0	0	0	2	0	2	2	2	5	4	2	2	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:113000008G>C	uc001ebx.2	+	6	2122	c.1894G>C	c.(1894-1896)GAG>CAG	p.E632Q	CTTNBP2NL_uc001ebz.2_Intron	NM_018704	NP_061174	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	632						actin cytoskeleton	protein binding			central_nervous_system(2)|ovary(1)	3		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TAAGGATGTTGAGTTACTTTT	0.478													47	61					0	0	0	0	C	113000008	C	C	113000008	3	2	36	1	0	0	0	0	1	0	0	0	4063	1291	45	2	1908	2	CTTNBP2NL	1	113000008	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3193718	113000008	136250613	49	6849											
HIPK1	204851	broad.mit.edu	37	chr1	114483834	114483834	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttggagcagaacttatatGattttctaaagcaaaacaaa	17	12	7	5	0	1	2	0	1	1	1	1	3	1	3	0	1	4	3	0	1	8	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:114483834G>C	uc001eem.2	+	2	990	c.829G>C	c.(829-831)GAT>CAT	p.D277H	HIPK1_uc001eel.2_Missense_Mutation_p.D277H|HIPK1_uc001een.2_Missense_Mutation_p.D277H	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	277	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACTTATATGATTTTCTAAA	0.408													33	61					0	0	0	0	C	114483834	C	C	114483834	3	2	36	1	0	0	0	0	1	0	0	0	7155	1290	45	2	831	2	HIPK1	1	114483834	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1483826	114483834	134766787	50	6850											
WARS2	10352	broad.mit.edu	37	chr1	119619152	119619152	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtaacctcacccagctctCaatggctcccaggtaattgc	9	10	7	15	0	2	0	2	0	1	0	4	0	3	0	3	2	3	4	3	2	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:119619152C>G	uc001ehn.2	-	2	197	c.169G>C	c.(169-171)GAG>CAG	p.E57Q	WARS2_uc010oxf.1_5'UTR|WARS2_uc001ehm.2_Missense_Mutation_p.E57Q|WARS2_uc010oxg.1_Missense_Mutation_p.E57Q|WARS2_uc010oxh.1_Missense_Mutation_p.E57Q|WARS2_uc010oxi.1_5'UTR	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	57					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	ACCCAGCTCTCAATGGCTCCC	0.483													64	145					0	0	0	0	G	119619152	G	G	119619152	3	3	36	1	0	0	0	0	1	0	0	0	17318	835	29	2	962	2	WARS2	1	119619152	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5135318	119619152	129631469	51	6851											
PDE4DIP	9659	broad.mit.edu	37	chr1	144882644	144882644	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctattcccttccttgctactCagcacaagttgttctttgag	7	16	6	12	0	2	1	1	1	1	0	4	1	4	1	2	0	3	4	2	0	3	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:144882644C>G	uc001elw.3	-	24	3666	c.3375G>C	c.(3373-3375)CTG>CTC	p.L1125L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Silent_p.L132L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1125					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CCTTGCTACTCAGCACAAGTT	0.463			T	PDGFRB	MPD								27	372					0	0	0	0	G	144882644	G	G	144882644	2	3	36	1	0	0	0	0	0	0	0	1	11697	813	29	2		2	PDE4DIP	1	144882644	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	25263492	144882644	104367977	52	6852											
SEC22B	9554	broad.mit.edu	37	chr1	145109554	145109554	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcagggggtgtgtgatttGgttttatgtgaagctgcctt	6	15	16	4	0	0	2	0	2	0	0	0	3	0	2	1	3	3	3	1	3	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:145109554G>C	uc001eml.1	+	5	356	c.216G>C	c.(214-216)TTG>TTC	p.L72F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron	NM_004892	NP_004883	O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B	72	Longin.|Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding				0						TGTGTGATTTGGTTTTATGTG	0.413													17	604					0	0	0	0	C	145109554	C	C	145109554	3	2	36	1	0	0	0	0	1	0	0	0	14054	1339	47	4	226	4	SEC22B	1	145109554	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	226910	145109554	104141067	53	6853											
CHD1L	9557	broad.mit.edu	37	chr1	146763163	146763163	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcctttctgttttacctcaGacctgagtttgggaggtgtc	5	16	10	10	0	2	2	1	1	1	1	4	3	3	3	3	2	1	2	3	2	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:146763163G>C	uc001epm.3	+	20	2384	c.2321_splice	c.e20-1	p.D774_splice	uc001epp.2_Intron|CHD1L_uc001epn.3_Splice_Site_p.D661_splice|CHD1L_uc010ozo.1_Splice_Site|CHD1L_uc009wjg.2_Splice_Site|CHD1L_uc009wjh.2_Splice_Site_p.D680_splice|CHD1L_uc010ozp.1_Splice_Site_p.D493_splice|CHD1L_uc001epo.3_Splice_Site_p.D570_splice|CHD1L_uc009wji.2_Splice_Site_p.D493_splice	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein						chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					TTTTACCTCAGACCTGAGTTT	0.398													16	102					0	0	0	0	C	146763163	C	C	146763163	5	2	36	1	0	0	0	0	0	0	1	0	3339	956	33	2	2398	2	CHD1L	1	146763163	Splice_Site	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1653609	146763163	102487458	54	6854											
HIST2H2BE	8349	broad.mit.edu	37	chr1	149857978	149857978	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcctctcccgcgatgcgctcGaagatgtcgttgacgaagga	8	8	13	12	6	1	2	0	1	1	1	4	6	1	3	2	1	1	2	2	1	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:149857978G>C	uc001etc.2	-	1	255	c.213C>G	c.(211-213)TTC>TTG	p.F71L	HIST2H2AC_uc001etd.2_5'Flank	NM_003528	NP_003519	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	71					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CGATGCGCTCGAAGATGTCGT	0.622													83	168					0	0	0	0	C	149857978	C	C	149857978	3	2	36	1	0	0	0	0	1	0	0	0	7218	1049	37	3	171	3	HIST2H2BE	1	149857978	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3094815	149857978	99392643	55	6855											
HIST2H2AB	317772	broad.mit.edu	37	chr1	149859411	149859411	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggagaccagcgcgggacGagcgcgacttggccttagcg	8	5	16	12	6	0	1	0	0	0	1	0	5	0	2	2	3	3	0	2	3	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:149859411G>T	uc001ete.2	-	1	56	c.56C>A	c.(55-57)TCG>TAG	p.S19*	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	19					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			AGCGCGGGACGAGCGCGACTT	0.622													58	125					3.30712e-30	3.55704e-30	1	0	T	149859411	T	T	149859411	4	4	36	1	0	0	0	0	0	1	0	0	7216	1059	37	3	340	3	HIST2H2AB	1	149859411	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1433	149859411	99391210	56	6856											
PLEKHO1	51177	broad.mit.edu	37	chr1	150131448	150131448	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaaactggaggagactcaGgagcttctggcagaggttca	12	7	15	7	0	3	2	2	0	1	2	3	6	3	5	0	6	2	3	0	6	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:150131448G>A	uc001ett.2	+	6	1238	c.960G>A	c.(958-960)CAG>CAA	p.Q320Q	PLEKHO1_uc001etr.2_Silent_p.Q148Q|PLEKHO1_uc001ets.2_Silent_p.Q137Q|PLEKHO1_uc001etu.2_Silent_p.Q148Q	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	320	Negative regulator of AP-1 activity.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGGAGACTCAGGAGCTTCTGG	0.647													4	117					0	0	0	0	A	150131448	A	A	150131448	2	1	36	1	0	0	0	0	0	0	0	1	12139	991	35	4		4	PLEKHO1	1	150131448	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	272037	150131448	99119173	57	6857											
C1orf51	148523	broad.mit.edu	37	chr1	150259239	150259239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgccagtaactctgccatCagactggagctataccctat	10	12	7	12	0	2	1	1	0	1	1	2	2	2	2	3	1	5	2	3	1	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:150259239C>T	uc001euh.2	+	6	1167	c.1031C>T	c.(1030-1032)TCA>TTA	p.S344L	C1orf51_uc001eui.2_Missense_Mutation_p.S256L|C1orf51_uc001euj.2_Missense_Mutation_p.S344L	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	344											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACTCTGCCATCAGACTGGAGC	0.542													56	117					0	0	0	0	T	150259239	T	T	150259239	3	4	36	1	0	0	0	0	1	0	0	0	2053	838	29	2	1049	2	C1orf51	1	150259239	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	127791	150259239	98991382	58	6858											
POGZ	23126	broad.mit.edu	37	chr1	151377284	151377284	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgaccccaacactcaaatCtccatcagatctaggtcagc	13	8	5	15	0	5	2	3	1	2	1	6	2	5	2	3	1	2	0	3	1	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:151377284C>G	uc001eyd.1	-	19	4533	c.4227G>C	c.(4225-4227)GAG>GAC	p.E1409D	POGZ_uc001eye.1_Missense_Mutation_p.E1356D|POGZ_uc010pdb.1_Missense_Mutation_p.E1400D|POGZ_uc001eyf.1_Missense_Mutation_p.E1365D|POGZ_uc010pdc.1_Missense_Mutation_p.E1347D|POGZ_uc009wmv.1_Missense_Mutation_p.E1314D|POGZ_uc010pdd.1_Missense_Mutation_p.E900D	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	1409					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACACTCAAATCTCCATCAGAT	0.507											OREG0003905	type=REGULATORY REGION|Gene=POGZ|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	34	73					0	0	0	0	G	151377284	G	G	151377284	3	3	36	1	0	0	0	0	1	0	0	0	12241	912	32	2	9	2	POGZ	1	151377284	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1118045	151377284	97873337	59	6859											
CGN	57530	broad.mit.edu	37	chr1	151491282	151491282	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcctcaggagctctgagctCagatttggaactccctgaga	9	9	12	11	0	3	3	2	2	1	2	4	6	4	5	2	3	3	2	2	3	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:151491282C>G	uc009wmw.2	+	2	431	c.287C>G	c.(286-288)TCA>TGA	p.S96*		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	90	Head.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCTCTGAGCTCAGATTTGGAA	0.577													26	53					0	0	0	0	G	151491282	G	G	151491282	4	3	36	1	0	0	0	0	0	1	0	0	3318	838	29	2	289	2	CGN	1	151491282	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	113998	151491282	97759339	60	6860											
FLG	2312	broad.mit.edu	37	chr1	152281432	152281432	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actctgtgtgacgagtgcctGattgtctggagctgtctgca	6	13	13	9	1	3	2	0	2	3	0	3	4	3	3	1	1	3	2	1	1	0	1	rs140980397		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:152281432G>C	uc001ezu.1	-	3	5966	c.5930C>G	c.(5929-5931)TCA>TGA	p.S1977*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1977	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACGAGTGCCTGATTGTCTGGA	0.572									Ichthyosis				278	515					0	0	0	0	C	152281432	C	C	152281432	4	2	36	1	0	0	0	0	0	1	0	0	5954	1294	45	2	6259	2	FLG	1	152281432	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	790150	152281432	96969189	61	6861											
FLG	2312	broad.mit.edu	37	chr1	152281579	152281579	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accacctctcagagtcttctGagtgtccctgactgtcactg	7	12	8	14	0	4	3	2	2	3	1	6	3	5	3	3	0	0	0	3	0	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:152281579G>A	uc001ezu.1	-	3	5819	c.5783C>T	c.(5782-5784)TCA>TTA	p.S1928L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1928	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGAGTCTTCTGAGTGTCCCTG	0.567									Ichthyosis				197	355					0	0	0	0	A	152281579	A	A	152281579	3	1	36	1	0	0	0	0	1	0	0	0	5954	1294	45	2	6406	2	FLG	1	152281579	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	147	152281579	96969042	62	6862											
FLG	2312	broad.mit.edu	37	chr1	152286936	152286936	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccctgtttctcttgggctCttggatcttcccttattccc	2	17	6	16	0	3	0	0	0	3	0	6	1	5	1	4	2	0	2	4	2	1	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:152286936C>G	uc001ezu.1	-	3	462	c.426G>C	c.(424-426)AAG>AAC	p.K142N	uc001ezv.2_Intron	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	142					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTTGGGCTCTTGGATCTTC	0.348									Ichthyosis				88	208					0	0	0	0	G	152286936	G	G	152286936	3	3	36	1	0	0	0	0	1	0	0	0	5954	912	32	2	11763	2	FLG	1	152286936	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5357	152286936	96963685	63	6863											
FLG	2312	broad.mit.edu	37	chr1	152286973	152286973	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccttttctattgtttcttCtttccagacttgagggtctt	4	21	6	10	0	4	2	0	1	4	1	6	2	6	2	2	1	0	1	2	1	1	9			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:152286973C>G	uc001ezu.1	-	3	425	c.389G>C	c.(388-390)AGA>ACA	p.R130T	uc001ezv.2_Intron	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	130					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTGTTTCTTCTTTCCAGACT	0.373									Ichthyosis				84	198					0	0	0	0	G	152286973	G	G	152286973	3	3	36	1	0	0	0	0	1	0	0	0	5954	913	32	2	11800	2	FLG	1	152286973	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	37	152286973	96963648	64	6864											
UBAP2L	9898	broad.mit.edu	37	chr1	154197669	154197669	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaaaaccaaaaccagacaCagcacaagcagcggccacag	18	1	7	15	1	1	1	1	0	0	1	1	1	1	1	3	1	5	2	3	1	5	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:154197669C>T	uc001fep.3	+	2	237	c.70C>T	c.(70-72)CAG>TAG	p.Q24*	UBAP2L_uc009wot.2_Nonsense_Mutation_p.Q24*|UBAP2L_uc010pek.1_Nonsense_Mutation_p.Q23*|UBAP2L_uc010pel.1_Nonsense_Mutation_p.Q23*|UBAP2L_uc001fen.1_Nonsense_Mutation_p.Q23*|UBAP2L_uc010pem.1_Nonsense_Mutation_p.Q23*	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	24					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AAACCAGACACAGCACAAGCA	0.453													6	66					0	0	0	0	T	154197669	T	T	154197669	4	4	36	1	0	0	0	0	0	1	0	0	16906	479	17	4	72	4	UBAP2L	1	154197669	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1910696	154197669	95052952	65	6865											
UBAP2L	9898	broad.mit.edu	37	chr1	154223669	154223669	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccacctccgtcttctcctCtgccaagcaaatccacatcg	8	10	4	19	2	3	0	0	0	3	0	8	0	6	0	6	0	2	1	6	0	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:154223669C>T	uc001fep.3	+	13	1533	c.1366C>T	c.(1366-1368)CTG>TTG	p.L456L	UBAP2L_uc009wot.2_Silent_p.L456L|UBAP2L_uc010pek.1_Silent_p.L448L|UBAP2L_uc010pel.1_Silent_p.L466L|UBAP2L_uc010pen.1_Silent_p.L370L	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	456					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GTCTTCTCCTCTGCCAAGCAA	0.547													88	142					0	0	0	0	T	154223669	T	T	154223669	2	4	36	1	0	0	0	0	0	0	0	1	16906	912	32	2		2	UBAP2L	1	154223669	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	26000	154223669	95026952	66	6866											
IL6R	3570	broad.mit.edu	37	chr1	154427027	154427027	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tggagggagcctggccttcgGaacgctcctctgcattgcca	6	9	13	13	2	1	0	0	0	1	0	3	3	2	3	4	4	4	2	4	4	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:154427027G>C	uc001fez.1	+	9	1567	c.1130G>C	c.(1129-1131)GGA>GCA	p.G377A	IL6R_uc001ffa.1_Intron	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	377	Helical; (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTGGCCTTCGGAACGCTCCTC	0.443													17	44					0	0	0	0	C	154427027	C	C	154427027	3	2	36	1	0	0	0	0	1	0	0	0	7741	1174	41	2	1164	2	IL6R	1	154427027	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	203358	154427027	94823594	67	6867											
ADAM15	8751	broad.mit.edu	37	chr1	155034448	155034448	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacccggtggtgagaagcccGaaggtaacggtggggggaga	10	4	20	7	3	0	2	0	1	0	2	0	6	0	2	2	7	2	1	2	7	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:155034448G>A	uc001fgr.1	+	21	2522	c.2421G>A	c.(2419-2421)CCG>CCA	p.P807P	EFNA3_uc010pew.1_5'Flank|ADAM15_uc001fgq.1_Silent_p.P491P|ADAM15_uc001fgt.1_Silent_p.P806P|ADAM15_uc010pev.1_Intron|ADAM15_uc001fgs.1_Intron|ADAM15_uc001fgu.1_Silent_p.P782P|ADAM15_uc001fgw.1_Intron|ADAM15_uc001fgv.1_Intron|ADAM15_uc001fgx.1_Intron|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_Intron|EFNA4_uc001fhc.2_5'Flank|EFNA4_uc001fhd.2_5'Flank|EFNA4_uc001fhe.2_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	807	Cytoplasmic (Potential).				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TGAGAAGCCCGAAGGTAACGG	0.677											OREG0013848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	97	141					0	0	0	0	A	155034448	A	A	155034448	2	1	36	1	0	0	0	0	0	0	0	1	237	1045	37	1		1	ADAM15	1	155034448	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	607421	155034448	94216173	68	6868											
CD1C	911	broad.mit.edu	37	chr1	158262651	158262651	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtctaggaggccaggacatCatcctctactggggtaagac	11	8	12	10	0	3	1	1	0	2	1	4	3	4	3	2	5	1	1	2	5	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:158262651C>T	uc001fru.2	+	4	1168	c.876C>T	c.(874-876)ATC>ATT	p.I292I	CD1C_uc001frv.2_Silent_p.I95I	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	292	Extracellular (Potential).|Ig-like.				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					GCCAGGACATCATCCTCTACT	0.527													12	45					0	0	0	0	T	158262651	T	T	158262651	2	4	36	1	0	0	0	0	0	0	0	1	2991	816	29	2		2	CD1C	1	158262651	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3228203	158262651	90987970	69	6869											
SPTA1	6708	broad.mit.edu	37	chr1	158621223	158621223	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatcatcagctaccttgttGatatcccttagccgaggctc	9	12	8	12	1	2	2	2	1	0	1	4	3	3	2	3	1	3	3	3	1	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:158621223G>C	uc001fst.1	-	24	3610	c.3411C>G	c.(3409-3411)ATC>ATG	p.I1137M		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1137	Spectrin 11.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTACCTTGTTGATATCCCTTA	0.438													98	183					0	0	0	0	C	158621223	C	C	158621223	3	2	36	1	0	0	0	0	1	0	0	0	15182	1280	45	2	3964	2	SPTA1	1	158621223	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	358572	158621223	90629398	70	6870											
MNDA	4332	broad.mit.edu	37	chr1	158812162	158812162	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacttgccaaagatatgccAtcacttaaaaaccttgttaa	16	11	5	9	0	1	1	1	0	0	1	1	2	1	1	3	0	4	1	3	0	7	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:158812162A>G	uc001fsz.1	+	2	419	c.219A>G	c.(217-219)CCA>CCG	p.P73P		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	73	DAPIN.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					AAGATATGCCATCACTTAAAA	0.373													50	112					0	0	0	0	G	158812162	G	G	158812162	2	3	36	1	0	0	0	0	0	0	0	1	9729	204	8	5		5	MNDA	1	158812162	Silent	SNP	A	TCGA-CN-4723-01A-01D-1434-08	190939	158812162	90438459	71	6871											
ATP1A2	477	broad.mit.edu	37	chr1	160106385	160106385	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccaggcactgggtggcttCttcacctactttgtgatcct	6	14	9	12	0	2	1	1	1	1	0	4	1	4	1	3	3	1	2	3	3	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:160106385C>G	uc001fvc.2	+	19	2721	c.2589C>G	c.(2587-2589)TTC>TTG	p.F863L	ATP1A2_uc001fvb.2_Missense_Mutation_p.F863L|ATP1A2_uc001fvd.2_Intron	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	863	Helical; (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGGGTGGCTTCTTCACCTACT	0.602													25	111					0	0	0	0	G	160106385	G	G	160106385	3	3	36	1	0	0	0	0	1	0	0	0	1131	912	32	2	2663	2	ATP1A2	1	160106385	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1294223	160106385	89144236	72	6872											
FCGR3A	2214	broad.mit.edu	37	chr1	161512965	161512965	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtacccaggtggaaagaatGatgagatggttgacactgcc	12	8	14	7	0	0	4	0	3	0	2	0	6	0	5	2	4	2	2	2	4	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:161512965G>A	uc001gat.3	-	6	739	c.602C>T	c.(601-603)TCA>TTA	p.S201L	FCGR3A_uc001gar.2_Missense_Mutation_p.S237L|FCGR3A_uc001gas.2_Missense_Mutation_p.S236L|FCGR3A_uc009wuh.2_Missense_Mutation_p.S200L|FCGR3A_uc009wui.2_Missense_Mutation_p.S201L	NM_001127595	NP_001121067	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor	201	Extracellular (Potential).				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TGGAAAGAATGATGAGATGGT	0.423													42	72					0	0	0	0	A	161512965	A	A	161512965	3	1	36	1	0	0	0	0	1	0	0	0	5816	1294	45	2	166	2	FCGR3A	1	161512965	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1406580	161512965	87737656	73	6873											
DCAF6	55827	broad.mit.edu	37	chr1	168014243	168014243	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccagaagaatctgcttcatCtgaaaaagccaaggaaccag	16	7	8	10	0	3	3	1	1	2	2	4	4	4	4	3	1	3	1	3	1	6	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:168014243C>G	uc001gew.2	+	14	2047	c.1805C>G	c.(1804-1806)TCT>TGT	p.S602C	DCAF6_uc001gev.2_Missense_Mutation_p.S622C|DCAF6_uc001gex.2_Missense_Mutation_p.S679C|DCAF6_uc010plk.1_Missense_Mutation_p.S648C|DCAF6_uc001gey.2_Missense_Mutation_p.S475C|DCAF6_uc001gez.2_Translation_Start_Site	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	602					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TCTGCTTCATCTGAAAAAGCC	0.443													24	168					0	0	0	0	G	168014243	G	G	168014243	3	3	36	1	0	0	0	0	1	0	0	0	4291	913	32	2	1923	2	DCAF6	1	168014243	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6501278	168014243	81236378	74	6874											
GPR161	23432	broad.mit.edu	37	chr1	168065809	168065809	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgttgcacaaatggttcccGataataccggtccccaaagc	11	9	8	13	3	0	0	0	0	0	0	3	1	2	0	4	2	3	3	4	2	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:168065809G>A	uc001gfc.2	-	5	1350	c.1036C>T	c.(1036-1038)CGG>TGG	p.R346W	GPR161_uc001gfb.2_Missense_Mutation_p.R214W|GPR161_uc010pll.1_Missense_Mutation_p.R256W|GPR161_uc010plm.1_Missense_Mutation_p.R232W|GPR161_uc009wvo.2_Missense_Mutation_p.R363W|GPR161_uc001gfd.2_Missense_Mutation_p.R346W|GPR161_uc010pln.1_Missense_Mutation_p.R366W|GPR161_uc001gfe.1_Missense_Mutation_p.R346W	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	346	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					AATGGTTCCCGATAATACCGG	0.527													44	66					0	0	0	0	A	168065809	A	A	168065809	3	1	36	1	0	0	0	0	1	0	0	0	6703	1057	37	1	569	1	GPR161	1	168065809	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	51566	168065809	81184812	75	6875											
TIPRL	261726	broad.mit.edu	37	chr1	168160697	168160697	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagttctcctttttgaggatGaacttcatgatcatggagtt	10	16	9	6	0	3	3	2	3	1	0	4	5	3	5	1	2	1	2	1	2	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:168160697G>A	uc001gfg.2	+	4	620	c.475G>A	c.(475-477)GAA>AAA	p.E159K	TIPRL_uc001gfh.2_Missense_Mutation_p.E159K|TIPRL_uc001gff.2_Missense_Mutation_p.E159K	NM_152902	NP_690866	O75663	TIPRL_HUMAN	TIP41, TOR signalling pathway regulator-like	159					DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			ovary(1)	1	all_hematologic(923;0.215)					TTTTGAGGATGAACTTCATGA	0.299													22	170					0	0	0	0	A	168160697	A	A	168160697	3	1	36	1	0	0	0	0	1	0	0	0	15992	1291	45	2	489	2	TIPRL	1	168160697	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	94888	168160697	81089924	76	6876											
C1orf9	51430	broad.mit.edu	37	chr1	172539802	172539802	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttcctctttttaaaataGagcacatctgctattcttat	10	18	3	10	0	3	1	0	0	3	1	4	1	4	1	2	0	2	2	2	0	5	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:172539802G>C	uc001giq.3	+	9	1298	c.982_splice	c.e9-1	p.S328_splice	C1orf9_uc010pmm.1_Splice_Site_p.S328_splice|C1orf9_uc009wwd.2_Splice_Site_p.S291_splice|C1orf9_uc010pmn.1_Splice_Site_p.S291_splice|C1orf9_uc010pmo.1_Splice_Site	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein						multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		TTTTAAAATAGAGCACATCTG	0.269													17	41					0	0	0	0	C	172539802	C	C	172539802	5	2	36	1	0	0	0	0	0	0	1	0	2077	956	33	2	1015	2	C1orf9	1	172539802	Splice_Site	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4379105	172539802	76710819	77	6877											
C1orf9	51430	broad.mit.edu	37	chr1	172558197	172558197	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcgcagccgaactgctttGagtaaaggaaaagattatct	14	9	10	8	2	1	2	0	1	1	1	1	4	1	3	1	1	4	3	1	1	6	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:172558197G>C	uc001giq.3	+	18	2272	c.1956G>C	c.(1954-1956)TTG>TTC	p.L652F	C1orf9_uc010pmm.1_Missense_Mutation_p.L652F|C1orf9_uc009wwd.2_Missense_Mutation_p.L608F|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	652					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		GAACTGCTTTGAGTAAAGGAA	0.393													25	43					0	0	0	0	C	172558197	C	C	172558197	3	2	36	1	0	0	0	0	1	0	0	0	2077	1281	45	2	2026	2	C1orf9	1	172558197	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	18395	172558197	76692424	78	6878											
DARS2	55157	broad.mit.edu	37	chr1	173795878	173795878	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggagagttgcgttcgtctCacttaggccaagaagtcacc	9	10	12	10	2	2	2	2	0	1	2	4	3	2	2	2	2	1	2	2	2	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:173795878C>T	uc001gjh.1	+	2	591	c.181C>T	c.(181-183)CAC>TAC	p.H61Y	CENPL_uc009wwg.2_5'Flank|CENPL_uc001gje.3_5'Flank|CENPL_uc001gjg.3_5'Flank|CENPL_uc001gjf.3_5'Flank	NM_018122	NP_060592	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	61					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			central_nervous_system(2)	2					L-Aspartic Acid(DB00128)	GCGTTCGTCTCACTTAGGCCA	0.388													18	134					0	0	0	0	T	173795878	T	T	173795878	3	4	36	1	0	0	0	0	1	0	0	0	4259	826	29	2	187	2	DARS2	1	173795878	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1237681	173795878	75454743	79	6879											
PAPPA2	60676	broad.mit.edu	37	chr1	176564298	176564298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaatggatactggccccttCggggagagaaggtgatacgc	11	7	14	9	2	0	2	0	1	0	1	1	5	0	4	2	5	2	0	2	5	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:176564298C>T	uc001gkz.2	+	3	2722	c.1558C>T	c.(1558-1560)CGG>TGG	p.R520W	PAPPA2_uc001gky.1_Missense_Mutation_p.R520W|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	520	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CTGGCCCCTTCGGGGAGAGAA	0.537													32	50					0	0	0	0	T	176564298	T	T	176564298	3	4	36	1	0	0	0	0	1	0	0	0	11487	875	31	1	1564	1	PAPPA2	1	176564298	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2768420	176564298	72686323	80	6880											
LHX4	89884	broad.mit.edu	37	chr1	180243597	180243597	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagggagtaagccagacgctGagagccatggctgggggacc	10	4	17	10	1	0	2	0	1	0	2	0	5	0	4	3	4	2	3	3	4	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:180243597G>C	uc001goe.1	+	6	1279	c.1056G>C	c.(1054-1056)CTG>CTC	p.L352L	uc001gof.1_Intron	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	352						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GCCAGACGCTGAGAGCCATGG	0.572													46	296					0	0	0	0	C	180243597	C	C	180243597	2	2	36	1	0	0	0	0	0	0	0	1	8814	1277	45	2		2	LHX4	1	180243597	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3679299	180243597	69007024	81	6881											
C1orf14	81626	broad.mit.edu	37	chr1	182869253	182869253	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgaagaagcccttttgttGagagcttcttctgctacgat	8	14	9	10	1	2	3	0	2	2	2	2	5	2	3	2	0	4	3	2	0	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:182869253G>C	uc001gpu.2	-	10	2112	c.1827C>G	c.(1825-1827)CTC>CTG	p.L609L	C1orf14_uc001gpv.2_Silent_p.L490L|C1orf14_uc010pnz.1_Silent_p.L467L|C1orf14_uc001gpw.2_Silent_p.L329L	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	681											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		CCCTTTTGTTGAGAGCTTCTT	0.313													9	62					0	0	0	0	C	182869253	C	C	182869253	2	2	36	1	0	0	0	0	0	0	0	1	2009	1277	45	2		2	C1orf14	1	182869253	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2625656	182869253	66381368	82	6882											
C1orf26	54823	broad.mit.edu	37	chr1	185143909	185143909	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagaaatggaagagaaatcaAttttctcaggattataactc	17	11	8	5	0	2	2	2	0	1	2	4	6	2	4	0	2	1	0	0	2	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:185143909A>G	uc001grg.3	+	5	744	c.630A>G	c.(628-630)CAA>CAG	p.Q210Q	C1orf26_uc001grh.3_Silent_p.Q210Q	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	210											0						AGAGAAATCAATTTTCTCAGG	0.348													34	170					0	0	0	0	G	185143909	G	G	185143909	2	3	36	1	0	0	0	0	0	0	0	1	2045	98	4	5		5	C1orf26	1	185143909	Silent	SNP	A	TCGA-CN-4723-01A-01D-1434-08	2274656	185143909	64106712	83	6883											
KIF14	9928	broad.mit.edu	37	chr1	200534687	200534687	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctatagttctttcttcatCataactctgtccaaaaaaat	13	16	3	9	0	5	0	2	0	3	0	6	0	6	0	1	0	2	2	1	0	6	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:200534687C>G	uc010ppk.1	-	24	4211	c.3772G>C	c.(3772-3774)GAT>CAT	p.D1258H	KIF14_uc010ppj.1_Missense_Mutation_p.D767H	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1258	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						CTTTCTTCATCATAACTCTGT	0.333													6	116					0	0	0	0	G	200534687	G	G	200534687	3	3	36	1	0	0	0	0	1	0	0	0	8315	826	29	2	1202	2	KIF14	1	200534687	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	15390778	200534687	48715934	84	6884											
KIF21B	23046	broad.mit.edu	37	chr1	200960823	200960823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggaccatctcctgctgccGcttctgggactccagagctc	6	9	10	16	1	2	1	0	0	2	1	5	3	3	3	4	2	3	3	4	2	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:200960823G>A	uc001gvs.1	-	17	2733	c.2416C>T	c.(2416-2418)CGG>TGG	p.R806W	KIF21B_uc001gvr.1_Missense_Mutation_p.R806W|KIF21B_uc009wzl.1_Missense_Mutation_p.R806W|KIF21B_uc010ppn.1_Missense_Mutation_p.R806W	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	806	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TCCTGCTGCCGCTTCTGGGAC	0.617													22	38					0	0	0	0	A	200960823	A	A	200960823	3	1	36	1	0	0	0	0	1	0	0	0	8328	1086	38	1	2530	1	KIF21B	1	200960823	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	426136	200960823	48289798	85	6885											
KLHL12	59349	broad.mit.edu	37	chr1	202861736	202861736	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcacgacttcccagctgtcGatgatagggtcataacattc	10	11	9	11	2	2	1	2	1	0	0	5	3	3	1	1	1	2	1	1	1	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:202861736G>A	uc001gyo.1	-	12	1832	c.1632C>T	c.(1630-1632)ATC>ATT	p.I544I	KLHL12_uc001gym.1_3'UTR|KLHL12_uc001gyn.1_3'UTR|KLHL12_uc010pqc.1_Silent_p.I582I	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	544	Kelch 6.|Interaction with DVL3.				Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			CCCAGCTGTCGATGATAGGGT	0.443													12	105					0	0	0	0	A	202861736	A	A	202861736	2	1	36	1	0	0	0	0	0	0	0	1	8407	1048	37	1		1	KLHL12	1	202861736	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1900913	202861736	46388885	86	6886											
TMCC2	9911	broad.mit.edu	37	chr1	205210816	205210816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgctctccggagatgcatCgcgtctcctacgccatgtcc	6	9	10	16	5	2	1	0	0	2	1	6	2	3	1	4	1	3	2	4	1	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:205210816C>T	uc001hbz.1	+	3	835	c.391C>T	c.(391-393)CGC>TGC	p.R131C	TMCC2_uc010prf.1_Missense_Mutation_p.R53C	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	131						integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GGAGATGCATCGCGTCTCCTA	0.657													25	27					0	0	0	0	T	205210816	T	T	205210816	3	4	36	1	0	0	0	0	1	0	0	0	16059	884	31	1	397	1	TMCC2	1	205210816	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2349080	205210816	44039805	87	6887											
FAIM3	9214	broad.mit.edu	37	chr1	207087216	207087216	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agctgtgttacctccactagGaacagattcttgcgtgggta	9	12	11	9	1	1	1	0	0	1	1	2	2	2	2	2	2	4	3	2	2	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:207087216G>C	uc001hey.2	-	2	440	c.261C>G	c.(259-261)TTC>TTG	p.F87L	FAIM3_uc010prz.1_Intron|FAIM3_uc010psa.1_Missense_Mutation_p.P31A|FAIM3_uc010psb.1_Missense_Mutation_p.F87L	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	87	Ig-like.|Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					CCTCCACTAGGAACAGATTCT	0.522													6	181					0	0	0	0	C	207087216	C	C	207087216	3	2	36	1	0	0	0	0	1	0	0	0	5405	1165	41	2	939	2	FAIM3	1	207087216	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1876400	207087216	42163405	88	6888											
PLXNA2	5362	broad.mit.edu	37	chr1	208218433	208218433	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaccttgtgctgcccggtGaggttgggaggctcgcagag	6	9	17	9	2	0	3	0	2	0	1	1	4	0	4	2	4	2	4	2	4	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:208218433G>A	uc001hgz.2	-	19	4376	c.3618C>T	c.(3616-3618)CTC>CTT	p.L1206L		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1206	IPT/TIG 4.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GCTGCCCGGTGAGGTTGGGAG	0.577													5	104					0	0	0	0	A	208218433	A	A	208218433	2	1	36	1	0	0	0	0	0	0	0	1	12175	1277	45	2		2	PLXNA2	1	208218433	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1131217	208218433	41032188	89	6889											
USH2A	7399	broad.mit.edu	37	chr1	216498758	216498758	+	Frame_Shift_Del	DEL	A	-	-																															ccaacatcattatcattgacAaaagagagaggatgggcttc																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:216498758delA	uc001hku.1	-	6	1419	c.1032delT	c.(1030-1032)TTTfs	p.F344fs	USH2A_uc001hkv.2_Frame_Shift_Del_p.F344fs	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	344	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TATCATTGACAAAAGAGAGAG	0.408										HNSCC(13;0.011)			---	---	---								-	216498758	-	-	216498758	7	5	36	1	0	1	0	1	0	0	0	0	17104	127	5	0	14858	0	USH2A	1	216498758	Frame_Shift_Del	DEL	A	TCGA-CN-4723-01A-01D-1434-08	8280325	216498758	32751863	90	6890											
DUSP10	11221	broad.mit.edu	37	chr1	221912637	221912637	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgccaagtcattggggtaGattattttgatgctggctag	8	16	12	5	0	1	2	1	1	0	1	1	2	1	2	1	3	2	3	1	3	4	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:221912637G>C	uc001hmy.1	-	2	632	c.450C>G	c.(448-450)ATC>ATG	p.I150M	DUSP10_uc001hmx.1_5'Flank|DUSP10_uc001hmz.1_Intron	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	150					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		CATTGGGGTAGATTATTTTGA	0.512													5	123					0	0	0	0	C	221912637	C	C	221912637	3	2	36	1	0	0	0	0	1	0	0	0	4832	932	33	2	1010	2	DUSP10	1	221912637	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5413879	221912637	27337984	91	6891											
CABC1	56997	broad.mit.edu	37	chr1	227171832	227171832	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accccttcttctatgtgcctGagattgtggatgagctctgc	6	14	10	11	0	3	2	0	2	3	1	3	4	3	3	3	1	3	1	3	1	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:227171832G>C	uc001hqm.1	+	16	4713	c.1294G>C	c.(1294-1296)GAG>CAG	p.E432Q	CABC1_uc001hqn.1_Missense_Mutation_p.E432Q|CABC1_uc009xeq.1_Missense_Mutation_p.E380Q|CABC1_uc010pvq.1_Missense_Mutation_p.E153Q|CABC1_uc010pvr.1_Missense_Mutation_p.E106Q|CABC1_uc001hqo.1_Missense_Mutation_p.E153Q|CABC1_uc009xer.1_5'UTR	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	432	Protein kinase.				cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				CTATGTGCCTGAGATTGTGGA	0.642													4	41					0	0	0	0	C	227171832	C	C	227171832	3	2	36	1	0	0	0	0	1	0	0	0	2539	1291	45	2	1332	2	CABC1	1	227171832	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5259195	227171832	22078789	92	6892											
DISC1	27185	broad.mit.edu	37	chr1	231830436	231830436	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tctggatccctcactggctgGctgtggtggtgatgggagca	5	11	16	9	0	2	1	1	1	1	0	3	3	3	3	1	6	1	3	1	6	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:231830436G>T	uc001huz.2	+	2	985	c.932G>T	c.(931-933)GGC>GTC	p.G311V	TSNAX-DISC1_uc010pwe.1_Missense_Mutation_p.G266V|TSNAX-DISC1_uc010pwf.1_Missense_Mutation_p.G266V|TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.G300V|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.G266V|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.G266V|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.G300V|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.G300V|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwo.1_Missense_Mutation_p.G311V|DISC1_uc010pwp.1_Missense_Mutation_p.G311V|DISC1_uc010pwq.1_Missense_Mutation_p.G311V|DISC1_uc010pwr.1_Missense_Mutation_p.G311V|DISC1_uc010pws.1_Missense_Mutation_p.G311V|DISC1_uc010pwt.1_Missense_Mutation_p.G311V|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.G311V|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.G311V|DISC1_uc010pxb.1_Missense_Mutation_p.G311V|DISC1_uc010pxc.1_Missense_Mutation_p.G311V|DISC1_uc010pxd.1_5'UTR|DISC1_uc010pxe.1_Missense_Mutation_p.G311V|DISC1_uc009xfr.2_Missense_Mutation_p.G266V|DISC1_uc010pxf.1_Missense_Mutation_p.G311V|DISC1_uc010pxg.1_Missense_Mutation_p.G311V|DISC1_uc010pxh.1_Missense_Mutation_p.G311V|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_5'UTR|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.G311V|DISC1_uc010pxn.1_5'UTR|DISC1_uc001hva.2_Missense_Mutation_p.G311V|DISC1_uc010pwm.1_Missense_Mutation_p.G311V|DISC1_uc001hux.1_Missense_Mutation_p.G311V|DISC1_uc001hvc.3_Missense_Mutation_p.G311V|DISC1_uc010pwn.1_Missense_Mutation_p.G311V	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	311	Interaction with TRAF3IP1.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				TCACTGGCTGGCTGTGGTGGT	0.617													16	87					6.49762e-13	6.81498e-13	1	0	T	231830436	T	T	231830436	3	4	36	1	0	0	0	0	1	0	0	0	4560	1203	42	4	938	4	DISC1	1	231830436	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4658604	231830436	17420185	93	6893											
SIPA1L2	57568	broad.mit.edu	37	chr1	232601014	232601014	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttcgagtggccattgctcGaaacttttctgatttatggg	7	15	11	8	3	1	1	0	1	1	0	3	3	1	1	1	2	2	2	1	2	2	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:232601014G>T	uc001hvg.2	-	7	2550	c.2392C>A	c.(2392-2394)CGA>AGA	p.R798R	SIPA1L2_uc001hvf.2_5'Flank	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	798	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GCCATTGCTCGAAACTTTTCT	0.468													30	194					2.47316e-13	2.59841e-13	1	0	T	232601014	T	T	232601014	2	4	36	1	0	0	0	0	0	0	0	1	14395	1066	37	3		3	SIPA1L2	1	232601014	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	770578	232601014	16649607	94	6894											
ERO1LB	56605	broad.mit.edu	37	chr1	236416724	236416724	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttattttatttattatacctCtggacagggctccacatgac	10	16	6	9	0	1	1	0	1	1	0	2	2	2	2	2	2	1	1	2	2	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:236416724C>G	uc001hxt.2	-	3	560	c.304G>C	c.(304-306)GAG>CAG	p.E102Q	ERO1LB_uc010pxt.1_Missense_Mutation_p.E102Q	NM_019891	NP_063944	Q86YB8	ERO1B_HUMAN	endoplasmic reticulum oxidoreductin 1-Lbeta	102					electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding				0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			TATTATACCTCTGGACAGGGC	0.383													22	34					0	0	0	0	G	236416724	G	G	236416724	3	3	36	1	0	0	0	0	1	0	0	0	5264	922	32	2	1155	2	ERO1LB	1	236416724	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3815710	236416724	12833897	95	6895											
HEATR1	55127	broad.mit.edu	37	chr1	236719107	236719107	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtgaacctgagcttacctCagagtgctgggctcggaagt	9	9	14	9	1	1	3	1	2	0	1	2	5	1	4	2	2	4	3	2	2	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:236719107C>T	uc001hyd.1	-	39	5772	c.5647G>A	c.(5647-5649)GAG>AAG	p.E1883K	HEATR1_uc009xgh.1_Missense_Mutation_p.E1045K	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1883					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			GAGCTTACCTCAGAGTGCTGG	0.493													11	217					0	0	0	0	T	236719107	T	T	236719107	3	4	36	1	0	0	0	0	1	0	0	0	7066	835	29	2	815	2	HEATR1	1	236719107	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	302383	236719107	12531514	96	6896											
CEP170	9859	broad.mit.edu	37	chr1	243319598	243319598	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taatccggtgtttgaatgaaGaactagtaggcattgctgat	12	13	11	5	1	0	4	0	3	0	1	1	4	1	4	1	2	2	4	1	2	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:243319598G>C	uc001hzs.2	-	14	4244	c.3836C>G	c.(3835-3837)TCT>TGT	p.S1279C	CEP170_uc001hzt.2_Missense_Mutation_p.S1145C|CEP170_uc001hzu.2_Missense_Mutation_p.S1181C|CEP170_uc001hzv.1_Missense_Mutation_p.S621C	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1279	Targeting to microtubules.|Targeting to centrosomes.					centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TTTGAATGAAGAACTAGTAGG	0.463													3	20					0	0	0	0	C	243319598	C	C	243319598	3	2	36	1	0	0	0	0	1	0	0	0	3265	942	33	2	976	2	CEP170	1	243319598	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	6600491	243319598	5931023	97	6897											
CEP170	9859	broad.mit.edu	37	chr1	243362377	243362377	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttacctgatgttccagcttCatggtttttttcttcaggtt	5	21	7	8	0	3	1	2	1	1	0	4	1	4	1	2	2	2	4	2	2	1	9			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:243362377C>T	uc001hzs.2	-	7	1024	c.616G>A	c.(616-618)GAA>AAA	p.E206K	CEP170_uc001hzt.2_Missense_Mutation_p.E206K|CEP170_uc001hzu.2_Missense_Mutation_p.E206K	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	206						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GTTCCAGCTTCATGGTTTTTT	0.403													4	35					0	0	0	0	T	243362377	T	T	243362377	3	4	36	1	0	0	0	0	1	0	0	0	3265	835	29	2	4224	2	CEP170	1	243362377	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	42779	243362377	5888244	98	6898											
SDCCAG8	10806	broad.mit.edu	37	chr1	243504340	243504340	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttttattttcccttacaGatgttgatcttgtctcagaa	9	18	6	8	0	2	3	1	1	2	2	4	4	3	3	1	0	1	1	1	0	3	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:243504340G>A	uc001hzw.2	+	11	1378	c.1222_splice	c.e11-1	p.M408_splice	SDCCAG8_uc010pyk.1_Splice_Site_p.M263_splice|SDCCAG8_uc010pyl.1_Splice_Site_p.M220_splice|SDCCAG8_uc001hzx.2_Splice_Site_p.M220_splice	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8						establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		TTCCCTTACAGATGTTGATCT	0.358													9	101					0	0	0	0	A	243504340	A	A	243504340	5	1	36	1	0	0	0	0	0	0	1	0	14024	956	33	2	1263	2	SDCCAG8	1	243504340	Splice_Site	SNP	G	TCGA-CN-4723-01A-01D-1434-08	141963	243504340	5746281	99	6899											
OR2T3	343173	broad.mit.edu	37	chr1	248637600	248637600	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcagtcaagaatgaaccaaGaaaagtagtaaagggcaagc	19	5	11	6	0	1	3	1	1	0	2	1	3	1	3	1	1	3	4	1	1	10	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr1:248637600G>C	uc001iel.1	+	1	949	c.949G>C	c.(949-951)GAA>CAA	p.E317Q		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	317	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AATGAACCAAGAAAAGTAGTA	0.502													101	353					0	0	0	0	C	248637600	C	C	248637600	3	2	36	1	0	0	0	0	1	0	0	0	11077	943	33	2	951	2	OR2T3	1	248637600	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5133260	248637600	613021	100	6900											
PXDN	7837	broad.mit.edu	37	chr2	1647338	1647338	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagaacaccccagggttctCataccacaacctggatcccc	11	6	8	16	0	1	1	1	0	1	1	3	3	2	2	6	3	3	1	6	3	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:1647338C>G	uc002qxa.2	-	19	3818	c.3754G>C	c.(3754-3756)GAG>CAG	p.E1252Q		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1252					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CCAGGGTTCTCATACCACAAC	0.557													29	74					0	0	0	0	G	1647338	G	G	1647338	3	3	36	1	0	0	0	0	1	0	0	0	12912	835	29	2	705	2	PXDN	2	1647338	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08		1647338	241552035	101	6901											
GRHL1	29841	broad.mit.edu	37	chr2	10098934	10098934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttccaagagagagaaggtCatcaacagcaaagccagagg	16	4	13	8	0	2	3	2	0	0	3	3	5	3	3	2	3	3	2	2	3	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:10098934C>T	uc002raa.2	+	3	398	c.227C>T	c.(226-228)TCA>TTA	p.S76L	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_5'UTR|GRHL1_uc010yjb.1_5'UTR|uc002rac.2_5'Flank	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	76	Transcription activation.				cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		GAGAGAAGGTCATCAACAGCA	0.443													15	46					0	0	0	0	T	10098934	T	T	10098934	3	4	36	1	0	0	0	0	1	0	0	0	6802	838	29	2	237	2	GRHL1	2	10098934	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	8451596	10098934	233100439	102	6902											
DDX1	1653	broad.mit.edu	37	chr2	15768620	15768620	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtagctgctagaggaattGatatccacggtgttccttat	10	14	10	7	1	0	2	0	1	0	1	2	3	2	3	2	2	2	4	2	2	5	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:15768620G>T	uc002rce.2	+	21	2026	c.1738G>T	c.(1738-1740)GAT>TAT	p.D580Y	DDX1_uc010yjq.1_Missense_Mutation_p.D488Y	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	580	Helicase C-terminal.|Necessary for interaction with replicase polyprotein 1ab nsp14 of IBV.|Necessary for interaction with HNRNPK.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		TAGAGGAATTGATATCCACGG	0.343													35	126					4.0492e-12	4.23609e-12	1	0	T	15768620	T	T	15768620	3	4	36	1	0	0	0	0	1	0	0	0	4358	1290	45	2	1820	2	DDX1	2	15768620	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5669686	15768620	227430753	103	6903											
GEN1	348654	broad.mit.edu	37	chr2	17947933	17947933	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggttggattagcaatacttCttggctgtgattatctccca	8	16	9	8	0	2	1	0	1	2	0	3	2	2	2	1	3	2	3	1	3	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:17947933C>T	uc002rct.2	+	5	686	c.613C>T	c.(613-615)CTT>TTT	p.L205F	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.L205F|GEN1_uc002rcu.2_Missense_Mutation_p.L205F	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	205	I-domain.				DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AGCAATACTTCTTGGCTGTGA	0.338								Homologous_recombination					23	95					0	0	0	0	T	17947933	T	T	17947933	3	4	36	1	0	0	0	0	1	0	0	0	6372	913	32	2	627	2	GEN1	2	17947933	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2179313	17947933	225251440	104	6904											
HS1BP3	64342	broad.mit.edu	37	chr2	20818831	20818831	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctcgtccatggcttggatCtgctcctgcggcttctgctg	3	14	11	13	2	3	0	0	0	3	0	6	1	5	1	2	3	3	4	2	3	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:20818831C>T	uc002rdw.1	-	7	1136	c.1095G>A	c.(1093-1095)CAG>CAA	p.Q365Q		NM_022460	NP_071905	Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	365					cell communication		phosphatidylinositol binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGCTTGGATCTGCTCCTGCG	0.617													22	85					0	0	0	0	T	20818831	T	T	20818831	2	4	36	1	0	0	0	0	0	0	0	1	7400	912	32	2		2	HS1BP3	2	20818831	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2870898	20818831	222380542	105	6905											
ITSN2	50618	broad.mit.edu	37	chr2	24440837	24440837	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aacaaaaatcagggccatctCcccttcagtgagaaagcctg	14	7	8	12	0	3	1	2	1	1	1	4	2	3	1	4	1	2	0	4	1	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:24440837C>G	uc002rfe.2	-	31	4003	c.3745G>C	c.(3745-3747)GAG>CAG	p.E1249Q	ITSN2_uc002rff.2_Missense_Mutation_p.E1222Q	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1249	DH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGGCCATCTCCCCTTCAGTG	0.463													35	84					0	0	0	0	G	24440837	G	G	24440837	3	3	36	1	0	0	0	0	1	0	0	0	7966	864	30	2	1388	2	ITSN2	2	24440837	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3622006	24440837	218758536	106	6906											
NCOA1	8648	broad.mit.edu	37	chr2	24985573	24985573	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagataaatgatcccgcactGagacacacaggcctctactg	13	8	8	12	1	1	3	0	2	1	2	2	4	2	3	2	1	1	1	2	1	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:24985573G>A	uc002rfk.2	+	20	4341	c.4083G>A	c.(4081-4083)CTG>CTA	p.L1361L	NCOA1_uc010eye.2_Silent_p.L1361L|NCOA1_uc002rfi.2_Silent_p.L1210L|NCOA1_uc002rfj.2_Silent_p.L1361L|NCOA1_uc002rfl.2_Silent_p.L1361L|NCOA1_uc010eyf.2_Intron	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	1361									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCCCGCACTGAGACACACAG	0.398			T	PAX3	alveolar rhadomyosarcoma								19	358					0	0	0	0	A	24985573	A	A	24985573	2	1	36	1	0	0	0	0	0	0	0	1	10282	1277	45	2		2	NCOA1	2	24985573	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	544736	24985573	218213800	107	6907											
EMILIN1	11117	broad.mit.edu	37	chr2	27305913	27305913	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccctggggagcaggactctCaagtcagcgagatcctcagt	9	7	12	13	1	3	1	3	0	1	1	5	4	4	3	3	3	2	1	3	3	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:27305913C>G	uc002rii.3	+	4	1902	c.1474C>G	c.(1474-1476)CAA>GAA	p.Q492E	EMILIN1_uc010eyq.1_Missense_Mutation_p.Q473E|EMILIN1_uc002rik.3_5'Flank	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	492					cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCAGGACTCTCAAGTCAGCGA	0.692													5	16					0	0	0	0	G	27305913	G	G	27305913	3	3	36	1	0	0	0	0	1	0	0	0	5117	827	29	2	1488	2	EMILIN1	2	27305913	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2320340	27305913	215893460	108	6908											
SLC30A3	7781	broad.mit.edu	37	chr2	27481696	27481696	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctccgtgcatgcagcctctCaggggtaaggcccggcggcg	5	6	15	15	4	1	0	1	0	1	0	3	0	2	0	4	5	3	3	4	5	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:27481696C>G	uc002rjk.2	-	2	388	c.202G>C	c.(202-204)GAG>CAG	p.E68Q	SLC30A3_uc002rjj.2_5'Flank|SLC30A3_uc010ylh.1_Missense_Mutation_p.E63Q	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	68	Cytoplasmic (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCAGCCTCTCAGGGGTAAGG	0.622													16	45					0	0	0	0	G	27481696	G	G	27481696	3	3	36	1	0	0	0	0	1	0	0	0	14620	835	29	2	992	2	SLC30A3	2	27481696	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	175783	27481696	215717677	109	6909											
KRTCAP3	200634	broad.mit.edu	37	chr2	27665754	27665754	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctggcgtccaggaaccttCttcgccctccactggtgaga	6	10	10	15	2	1	1	0	1	1	1	5	3	4	2	5	3	1	0	5	3	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:27665754C>T	uc002rks.2	+	3	276	c.259C>T	c.(259-261)CTT>TTT	p.L87F	KRTCAP3_uc010ylr.1_Missense_Mutation_p.L87F|KRTCAP3_uc002rkt.2_Missense_Mutation_p.L69F	NM_173853	NP_776252	Q53RY4	KCP3_HUMAN	keratinocyte associated protein 3	87						integral to membrane					0	Acute lymphoblastic leukemia(172;0.155)					CAGGAACCTTCTTCGCCCTCC	0.592													32	47					0	0	0	0	T	27665754	T	T	27665754	3	4	36	1	0	0	0	0	1	0	0	0	8619	913	32	2	269	2	KRTCAP3	2	27665754	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	184058	27665754	215533619	110	6910											
PLB1	151056	broad.mit.edu	37	chr2	28741373	28741373	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccatgcaacccaaataaatTaggagtgaatatgccttcta	15	10	6	10	0	1	1	0	1	1	0	1	2	1	2	3	1	3	1	3	1	8	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:28741373T>C	uc002rmb.1	+	3	158	c.158T>C	c.(157-159)TTA>TCA	p.L53S	PLB1_uc010ezj.1_Missense_Mutation_p.L53S	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	53	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CCAAATAAATTAGGAGTGAAT	0.443													61	127					0	0	0	0	C	28741373	C	C	28741373	3	2	36	1	0	0	0	0	1	0	0	0	12079	1764	61	5	168	5	PLB1	2	28741373	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	1075619	28741373	214458000	111	6911											
RASGRP3	25780	broad.mit.edu	37	chr2	33752314	33752314	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccatccttggagtacacttGaaagacttgatagctgtcca	11	11	8	11	0	0	3	0	2	0	1	2	4	2	4	3	1	2	2	3	1	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:33752314G>A	uc002rox.2	+	11	1545	c.918G>A	c.(916-918)TTG>TTA	p.L306L	RASGRP3_uc010ync.1_Silent_p.L306L|RASGRP3_uc002roy.2_Silent_p.L306L	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	306	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					GAGTACACTTGAAAGACTTGA	0.473													10	58					0	0	0	0	A	33752314	A	A	33752314	2	1	36	1	0	0	0	0	0	0	0	1	13141	1281	45	2		2	RASGRP3	2	33752314	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5010941	33752314	209447059	112	6912											
FAM98A	25940	broad.mit.edu	37	chr2	33824236	33824236	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgtgccctgacaatcttacCctagatcttccaacgactcc	9	10	5	17	2	2	2	0	1	2	1	4	3	4	2	5	0	3	0	5	0	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:33824236C>G	uc002rpa.1	-	1	127	c.53G>C	c.(52-54)GGT>GCT	p.G18A	FAM98A_uc010yne.1_5'UTR	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	18										ovary(1)	1	all_hematologic(175;0.115)					ACAATCTTACCCTAGATCTTC	0.597													5	258					0	0	0	0	G	33824236	G	G	33824236	3	3	36	1	0	0	0	0	1	0	0	0	5688	637	22	4	1535	4	FAM98A	2	33824236	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	71922	33824236	209375137	113	6913											
DHX57	90957	broad.mit.edu	37	chr2	39053158	39053158	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgagatacaaaggtgtcctCtagactttccatccctttgc	9	14	7	11	0	1	2	0	1	1	2	4	3	4	2	3	1	2	0	3	1	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:39053158C>G	uc002rrf.2	-	16	2944	c.2845G>C	c.(2845-2847)GAG>CAG	p.E949Q	DHX57_uc002rrd.3_Missense_Mutation_p.E333Q|DHX57_uc002rre.2_Missense_Mutation_p.E382Q	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	949	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				AAGGTGTCCTCTAGACTTTCC	0.408													21	77					0	0	0	0	G	39053158	G	G	39053158	3	3	36	1	0	0	0	0	1	0	0	0	4535	922	32	2	1351	2	DHX57	2	39053158	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5228922	39053158	204146215	114	6914											
ZFP36L2	678	broad.mit.edu	37	chr2	43452225	43452225	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaagcccaggtgcaacgcatCgcgcgtgccaaaggcacgca	11	3	13	14	5	0	0	0	0	0	0	1	1	0	0	2	2	4	4	2	2	3	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:43452225C>G	uc002rsv.3	-	2	1009	c.718G>C	c.(718-720)GAT>CAT	p.D240H	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	240					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				TGCAACGCATCGCGCGTGCCA	0.612													6	16					0	0	0	0	G	43452225	G	G	43452225	3	3	36	1	0	0	0	0	1	0	0	0	17714	884	31	3	770	3	ZFP36L2	2	43452225	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4399067	43452225	199747148	115	6915											
ABCG8	64241	broad.mit.edu	37	chr2	44079754	44079754	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggaatccttattctcgaCgaacccacctctgggctcga	11	9	8	13	3	2	0	0	0	2	0	5	4	3	1	3	2	1	1	3	2	4	2	rs55702734		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:44079754C>A	uc002rtq.2	+	6	801	c.711C>A	c.(709-711)GAC>GAA	p.D237E	ABCG8_uc010yoa.1_Missense_Mutation_p.D237E	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	237	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TTATTCTCGACGAACCCACCT	0.612													63	133					1.84395e-34	1.99381e-34	1	0	A	44079754	A	A	44079754	3	1	36	1	0	0	0	0	1	0	0	0	72	535	19	3	733	3	ABCG8	2	44079754	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	627529	44079754	199119619	116	6916											
LRPPRC	10128	broad.mit.edu	37	chr2	44161341	44161341	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcacacctcaatgatcttCttggcctctttgtaatttcc	9	16	4	12	0	5	1	2	1	3	0	6	1	6	1	3	1	0	1	3	1	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:44161341C>T	uc002rtr.2	-	25	2782	c.2724G>A	c.(2722-2724)AAG>AAA	p.K908K	LRPPRC_uc010yob.1_Silent_p.K808K	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	908					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CAATGATCTTCTTGGCCTCTT	0.338													12	62					0	0	0	0	T	44161341	T	T	44161341	2	4	36	1	0	0	0	0	0	0	0	1	9015	912	32	2		2	LRPPRC	2	44161341	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	81587	44161341	199038032	117	6917											
PREPL	9581	broad.mit.edu	37	chr2	44549940	44549940	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtataacttacaattcctttCagaggtacccgttcatcgtt	10	15	6	10	2	2	1	2	0	0	1	4	1	3	1	2	1	3	4	2	1	5	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:44549940C>G	uc002ruf.2	-	12	1985	c.1950G>C	c.(1948-1950)CTG>CTC	p.L650L	PREPL_uc002rug.2_Silent_p.L584L|PREPL_uc002ruh.2_Silent_p.L588L|PREPL_uc010fax.2_Silent_p.L650L|PREPL_uc002rui.3_Silent_p.L561L|PREPL_uc002ruj.1_Silent_p.L561L|PREPL_uc002ruk.1_Silent_p.L650L	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	650					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CAATTCCTTTCAGAGGTACCC	0.423													80	189					0	0	0	0	G	44549940	G	G	44549940	2	3	36	1	0	0	0	0	0	0	0	1	12537	813	29	2		2	PREPL	2	44549940	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	388599	44549940	198649433	118	6918											
SRBD1	55133	broad.mit.edu	37	chr2	45807146	45807146	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tttgcttccagttttatatgGagcagactagaaaataaaga	15	13	8	5	0	0	3	0	0	0	3	1	4	1	4	1	1	2	3	1	1	7	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:45807146G>C	uc002rus.2	-	7	1016	c.940C>G	c.(940-942)CCA>GCA	p.P314A		NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	314					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			GTTTTATATGGAGCAGACTAG	0.398													4	196					0	0	0	0	C	45807146	C	C	45807146	3	2	36	1	0	0	0	0	1	0	0	0	15199	1174	41	2	2107	2	SRBD1	2	45807146	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1257206	45807146	197392227	119	6919											
KLRAQ1	129285	broad.mit.edu	37	chr2	48698496	48698496	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaggaagattcttccctatCagttaaaaaggtagttaccc	13	13	7	8	0	2	1	1	0	1	1	3	2	3	2	2	2	1	3	2	2	8	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:48698496C>T	uc002rwm.2	+	11	1263	c.1078C>T	c.(1078-1080)CAG>TAG	p.Q360*	KLRAQ1_uc002rwi.1_Nonsense_Mutation_p.Q360*|KLRAQ1_uc002rwj.2_Nonsense_Mutation_p.Q360*|KLRAQ1_uc002rwl.2_Nonsense_Mutation_p.Q314*|KLRAQ1_uc002rwk.2_Nonsense_Mutation_p.Q360*|KLRAQ1_uc010yok.1_Nonsense_Mutation_p.Q360*	NM_001135629	NP_001129101	Q6ZMI0	KLRAQ_HUMAN	KLRAQ motif containing 1 isoform 1	360										ovary(1)	1						TCTTCCCTATCAGTTAAAAAG	0.388													32	113					0	0	0	0	T	48698496	T	T	48698496	4	4	36	1	0	0	0	0	0	1	0	0	8452	827	29	2	1120	2	KLRAQ1	2	48698496	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2891350	48698496	194500877	120	6920											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48809196	48809196	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcctattatgagaaggactCagaaaaaaaggggattgata	18	9	10	4	0	1	3	1	2	0	2	2	6	2	5	1	3	0	0	1	3	7	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:48809196C>G	uc010yol.1	+	1	1471	c.1424C>G	c.(1423-1425)TCA>TGA	p.S475*	STON1_uc002rwo.3_Nonsense_Mutation_p.S475*|STON1_uc010fbm.2_Nonsense_Mutation_p.S475*|STON1-GTF2A1L_uc002rwp.1_Nonsense_Mutation_p.S475*|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Nonsense_Mutation_p.S475*	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	475					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GAGAAGGACTCAGAAAAAAAG	0.368													41	142					0	0	0	0	G	48809196	G	G	48809196	4	3	36	1	0	0	0	0	0	1	0	0	15383	838	29	2	1426	2	STON1-GTF2A1L	2	48809196	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	110700	48809196	194390177	121	6921											
NRXN1	9378	broad.mit.edu	37	chr2	51254859	51254859	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggagttgaccctcacgtcacGaatccaccccttgaagggct	9	8	10	14	2	2	2	2	2	0	0	3	4	3	3	4	2	0	2	4	2	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:51254859G>C	uc010fbq.2	-	2	2030	c.553C>G	c.(553-555)CGT>GGT	p.R185G	NRXN1_uc002rxe.3_Missense_Mutation_p.R185G|NRXN1_uc002rxd.1_Missense_Mutation_p.R185G	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CTCACGTCACGAATCCACCCC	0.706													3	10					0	0	0	0	C	51254859	C	C	51254859	3	2	36	1	0	0	0	0	1	0	0	0	10719	1058	37	3	4445	3	NRXN1	2	51254859	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2445663	51254859	191944514	122	6922											
CCT7	10574	broad.mit.edu	37	chr2	73470151	73470151	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgggtgatggcaccacctCagtgaccttgctggctgcag	6	9	15	11	0	1	2	1	2	0	0	1	2	1	2	3	4	2	4	3	4	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:73470151C>G	uc002siz.2	+	4	389	c.287C>G	c.(286-288)TCA>TGA	p.S96*	CCT7_uc002sja.2_Intron|CCT7_uc010yrf.1_Nonsense_Mutation_p.S52*|CCT7_uc010feu.2_Intron|CCT7_uc010yrg.1_Intron|CCT7_uc010yrh.1_5'UTR|CCT7_uc010yri.1_Nonsense_Mutation_p.S9*	NM_006429	NP_006420	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 isoform a	96					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding				0						GGCACCACCTCAGTGACCTTG	0.502													24	74					0	0	0	0	G	73470151	G	G	73470151	4	3	36	1	0	0	0	0	0	1	0	0	2974	838	29	2	301	2	CCT7	2	73470151	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	22215292	73470151	169729222	123	6923											
ALMS1	7840	broad.mit.edu	37	chr2	73651682	73651682	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagtcgctttagtgtatctCagcacccgcttataggcagc	8	11	10	12	2	1	0	1	0	1	0	3	0	1	0	1	1	2	6	1	1	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:73651682C>T	uc002sje.1	+	6	1003	c.892C>T	c.(892-894)CAG>TAG	p.Q298*	ALMS1_uc002sjf.1_Nonsense_Mutation_p.Q255*	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	297					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TAGTGTATCTCAGCACCCGCT	0.448													17	46					0	0	0	0	T	73651682	T	T	73651682	4	4	36	1	0	0	0	0	0	1	0	0	535	827	29	2	907	2	ALMS1	2	73651682	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	181531	73651682	169547691	124	6924											
GPAT2	150763	broad.mit.edu	37	chr2	96690536	96690536	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctaccttctgatgcttgaaGagcagcagcgttgccataat	10	11	9	11	1	1	3	0	2	1	1	1	3	1	3	3	0	6	4	3	0	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:96690536G>T	uc002svf.2	-	14	1636	c.1413C>A	c.(1411-1413)CTC>CTA	p.L471L	GPAT2_uc002svd.2_Silent_p.L284L|GPAT2_uc002sve.2_Silent_p.L273L|GPAT2_uc002svg.2_Silent_p.L344L|GPAT2_uc010yuh.1_Silent_p.L400L|GPAT2_uc002svh.2_Silent_p.L471L	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	471	Helical; (Potential).				glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						GATGCTTGAAGAGCAGCAGCG	0.657													81	246					5.01443e-46	5.44118e-46	1	0	T	96690536	T	T	96690536	2	4	36	1	0	0	0	0	0	0	0	1	6627	929	33	2		2	GPAT2	2	96690536	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	23038854	96690536	146508837	125	6925											
GPAT2	150763	broad.mit.edu	37	chr2	96690561	96690561	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcgttgccataatggccGtgctcatcaccgcagagctc	8	8	11	14	3	2	1	2	0	0	1	3	1	2	1	3	1	4	5	3	1	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:96690561G>T	uc002svf.2	-	14	1611	c.1388C>A	c.(1387-1389)ACG>AAG	p.T463K	GPAT2_uc002svd.2_Missense_Mutation_p.T276K|GPAT2_uc002sve.2_Missense_Mutation_p.T265K|GPAT2_uc002svg.2_Missense_Mutation_p.T336K|GPAT2_uc010yuh.1_Missense_Mutation_p.T392K|GPAT2_uc002svh.2_Missense_Mutation_p.T463K	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	463	Helical; (Potential).				glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						CATAATGGCCGTGCTCATCAC	0.642													63	209					1.72039e-30	1.85203e-30	1	0	T	96690561	T	T	96690561	3	4	36	1	0	0	0	0	1	0	0	0	6627	1145	40	3	1035	3	GPAT2	2	96690561	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	25	96690561	146508812	126	6926											
IL18RAP	8807	broad.mit.edu	37	chr2	103068542	103068542	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaaaaactctcagggattCacgtggaaccagctcagaat	14	8	10	9	1	3	2	3	1	1	1	4	4	3	4	1	2	3	1	1	2	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:103068542C>T	uc002tbx.2	+	12	2185	c.1701C>T	c.(1699-1701)TTC>TTT	p.F567F	IL18RAP_uc010fiz.2_Silent_p.F425F	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	567	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						CTCAGGGATTCACGTGGAACC	0.478													35	209					0	0	0	0	T	103068542	T	T	103068542	2	4	36	1	0	0	0	0	0	0	0	1	7687	825	29	2		2	IL18RAP	2	103068542	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6377981	103068542	140130831	127	6927											
MYO7B	4648	broad.mit.edu	37	chr2	128366312	128366312	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcatcccggccgaggggcaGaaaagccaaggcgctctccc	9	4	13	15	3	2	1	1	0	1	1	4	2	3	1	4	4	1	2	4	4	3	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:128366312G>A	uc002top.2	+	22	2726	c.2673G>A	c.(2671-2673)CAG>CAA	p.Q891Q		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	891						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CCGAGGGGCAGAAAAGCCAAG	0.657													6	35					0	0	0	0	A	128366312	A	A	128366312	2	1	36	1	0	0	0	0	0	0	0	1	10136	933	33	2		2	MYO7B	2	128366312	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	25297770	128366312	114833061	128	6928											
POLR2D	5433	broad.mit.edu	37	chr2	128610608	128610608	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgttcgtcctctgcactctCattctgctgctttcgatgtt	3	18	7	13	2	3	0	1	0	3	0	7	1	4	0	1	0	3	5	1	0	0	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:128610608C>G	uc002tpj.2	-	2	200	c.145G>C	c.(145-147)GAG>CAG	p.E49Q	POLR2D_uc002tpk.2_Missense_Mutation_p.E49Q	NM_004805	NP_004796	O15514	RPB4_HUMAN	DNA directed RNA polymerase II polypeptide D	49					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|nucleotide binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0675)		TCTGCACTCTCATTCTGCTGC	0.418													51	217					0	0	0	0	G	128610608	G	G	128610608	3	3	36	1	0	0	0	0	1	0	0	0	12272	835	29	2	295	2	POLR2D	2	128610608	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	244296	128610608	114588765	129	6929											
NCKAP5	344148	broad.mit.edu	37	chr2	133541612	133541612	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcggaggggaaggggatttCacccctgcctccggcccaga	7	5	16	13	2	1	1	1	0	0	1	2	4	2	4	5	7	1	0	5	7	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:133541612C>T	uc002ttp.2	-	14	3146	c.2772G>A	c.(2770-2772)GTG>GTA	p.V924V	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	924							protein binding				0						AAGGGGATTTCACCCCTGCCT	0.622													21	38					0	0	0	0	T	133541612	T	T	133541612	2	4	36	1	0	0	0	0	0	0	0	1	10277	813	29	2		2	NCKAP5	2	133541612	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4931004	133541612	109657761	130	6930											
NCKAP5	344148	broad.mit.edu	37	chr2	133542513	133542513	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagacccacatagagattttCcaaaccccacaaggacatcc	15	6	6	14	0	0	2	0	0	0	2	2	5	2	3	5	1	1	0	5	1	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:133542513C>G	uc002ttp.2	-	14	2245	c.1871G>C	c.(1870-1872)GGA>GCA	p.G624A	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	624							protein binding				0						TAGAGATTTTCCAAACCCCAC	0.473													18	76					0	0	0	0	G	133542513	G	G	133542513	3	3	36	1	0	0	0	0	1	0	0	0	10277	855	30	2	3886	2	NCKAP5	2	133542513	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	901	133542513	109656860	131	6931											
YSK4	80122	broad.mit.edu	37	chr2	135745719	135745719	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcttaggcacaaaagatgtGagacttggaatgtttctttc	12	13	10	6	0	1	2	0	1	1	2	2	4	1	3	0	2	1	3	0	2	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:135745719G>C	uc002tue.1	-	7	754	c.723C>G	c.(721-723)CTC>CTG	p.L241L	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Silent_p.L128L|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_5'UTR|YSK4_uc002tui.3_Silent_p.L258L	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	241							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CAAAAGATGTGAGACTTGGAA	0.473													34	168					0	0	0	0	C	135745719	C	C	135745719	2	2	36	1	0	0	0	0	0	0	0	1	17563	1277	45	2		2	YSK4	2	135745719	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2203206	135745719	107453654	132	6932											
MCM6	4175	broad.mit.edu	37	chr2	136620310	136620310	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggacaccccgttttacttCatcattgcctgaaatgaaaa	13	11	6	11	1	2	2	2	2	0	0	2	3	2	3	3	1	2	1	3	1	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:136620310C>T	uc002tuw.2	-	8	1163	c.1087G>A	c.(1087-1089)GAA>AAA	p.E363K		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	363	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	CGTTTTACTTCATCATTGCCT	0.408													40	80					0	0	0	0	T	136620310	T	T	136620310	3	4	36	1	0	0	0	0	1	0	0	0	9444	835	29	2	1418	2	MCM6	2	136620310	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	874591	136620310	106579063	133	6933											
NEB	4703	broad.mit.edu	37	chr2	152548584	152548584	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaacttacatcactgttttGagctgcaactttcatgcagt	11	14	6	10	0	2	1	2	1	0	0	2	1	2	1	0	0	6	4	0	0	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:152548584G>C	uc010fnx.2	-	22	2286	c.2095C>G	c.(2095-2097)CAA>GAA	p.Q699E	NEB_uc010fny.1_Missense_Mutation_p.Q253E	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	699	Nebulin 16.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCACTGTTTTGAGCTGCAACT	0.373													49	170					0	0	0	0	C	152548584	C	C	152548584	3	2	36	1	0	0	0	0	1	0	0	0	10356	1299	45	2	24235	2	NEB	2	152548584	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	15928274	152548584	90650789	134	6934											
FMNL2	114793	broad.mit.edu	37	chr2	153415272	153415272	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgggtcagagaatttctGaatgaagaaaacaaaggtct	17	9	11	4	0	3	5	1	2	2	3	3	6	3	5	0	2	1	0	0	2	6	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:153415272G>C	uc002tye.2	+	5	745	c.378G>C	c.(376-378)CTG>CTC	p.L126L		NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	126	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						GAGAATTTCTGAATGAAGAAA	0.368													8	30					0	0	0	0	C	153415272	C	C	153415272	2	2	36	1	0	0	0	0	0	0	0	1	5984	1277	45	2		2	FMNL2	2	153415272	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	866688	153415272	89784101	135	6935											
GPD2	2820	broad.mit.edu	37	chr2	157425415	157425415	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaatctgcagatactcagtCtatctcccgaaatcatgttg	12	12	6	11	1	5	1	2	0	3	1	6	2	5	1	1	0	2	2	1	0	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:157425415C>G	uc002tzf.3	+	10	1604	c.1244C>G	c.(1243-1245)TCT>TGT	p.S415C	GPD2_uc010zch.1_Missense_Mutation_p.S188C|GPD2_uc002tzd.3_Missense_Mutation_p.S415C|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	415					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						GATACTCAGTCTATCTCCCGA	0.413													61	241					0	0	0	0	G	157425415	G	G	157425415	3	3	36	1	0	0	0	0	1	0	0	0	6644	913	32	2	1278	2	GPD2	2	157425415	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4010143	157425415	85773958	136	6936											
ACVR1C	130399	broad.mit.edu	37	chr2	158399269	158399269	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcgatagtgttcagtattGaatcatgcttcacagccaac	11	13	8	9	1	3	1	3	1	0	0	4	2	3	1	1	0	3	3	1	0	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:158399269G>C	uc002tzk.3	-	6	1292	c.1049C>G	c.(1048-1050)TCA>TGA	p.S350*	ACVR1C_uc002tzl.3_Nonsense_Mutation_p.S270*|ACVR1C_uc010fof.2_Nonsense_Mutation_p.S193*|ACVR1C_uc010foe.2_Nonsense_Mutation_p.S300*	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	350	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						GTTCAGTATTGAATCATGCTT	0.418													72	150					0	0	0	0	C	158399269	C	C	158399269	4	2	36	1	0	0	0	0	0	1	0	0	222	1294	45	2	448	2	ACVR1C	2	158399269	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	973854	158399269	84800104	137	6937											
BAZ2B	29994	broad.mit.edu	37	chr2	160295624	160295624	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatcttcttctagatcatCtgaatcactgctactaatgc	10	16	4	11	0	7	2	3	1	4	1	7	2	7	2	0	0	3	1	0	0	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:160295624C>G	uc002uao.2	-	7	1148	c.796G>C	c.(796-798)GAT>CAT	p.D266H	BAZ2B_uc002uap.2_Missense_Mutation_p.D264H|BAZ2B_uc002uas.1_Missense_Mutation_p.D203H|BAZ2B_uc002uau.1_Missense_Mutation_p.D264H|BAZ2B_uc002uaq.1_Missense_Mutation_p.D194H|BAZ2B_uc002uat.3_Missense_Mutation_p.D203H|BAZ2B_uc010fop.1_Missense_Mutation_p.D264H	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	266					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						tctAGATCATCTGAATCACTG	0.333													71	184					0	0	0	0	G	160295624	G	G	160295624	3	3	36	1	0	0	0	0	1	0	0	0	1334	913	32	2	5834	2	BAZ2B	2	160295624	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1896355	160295624	82903749	138	6938											
BAZ2B	29994	broad.mit.edu	37	chr2	160295712	160295712	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctagaactttccattgctttCttccttggtttctggataac	7	18	6	10	0	2	1	0	0	2	1	4	2	4	2	2	2	3	2	2	2	3	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:160295712C>G	uc002uao.2	-	7	1060	c.708G>C	c.(706-708)AAG>AAC	p.K236N	BAZ2B_uc002uap.2_Missense_Mutation_p.K234N|BAZ2B_uc002uas.1_Missense_Mutation_p.K173N|BAZ2B_uc002uau.1_Missense_Mutation_p.K234N|BAZ2B_uc002uaq.1_Missense_Mutation_p.K164N|BAZ2B_uc002uat.3_Missense_Mutation_p.K173N|BAZ2B_uc010fop.1_Missense_Mutation_p.K234N	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	236	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CCATTGCTTTCTTCCTTGGTT	0.353													71	162					0	0	0	0	G	160295712	G	G	160295712	3	3	36	1	0	0	0	0	1	0	0	0	1334	912	32	2	5922	2	BAZ2B	2	160295712	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	88	160295712	82903661	139	6939											
KCNH7	90134	broad.mit.edu	37	chr2	163393474	163393474	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taatattgggtttaccctctCtggggtggcagcgttttcat	6	16	11	8	1	2	0	1	0	1	0	3	0	2	0	1	4	2	3	1	4	3	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:163393474C>G	uc002uch.1	-	3	636	c.424G>C	c.(424-426)GAG>CAG	p.E142Q	KCNH7_uc002uci.2_Missense_Mutation_p.E142Q	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	142	Cytoplasmic (Potential).|PAC.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity	p.E142E(1)		ovary(3)|skin(2)	5					Ibutilide(DB00308)	TTTACCCTCTCTGGGGTGGCA	0.378													63	184					0	0	0	0	G	163393474	G	G	163393474	3	3	36	1	0	0	0	0	1	0	0	0	8076	922	32	2	3288	2	KCNH7	2	163393474	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3097762	163393474	79805899	140	6940											
FIGN	55137	broad.mit.edu	37	chr2	164466133	164466133	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttgagatatgctaggctGaatcttgcagaaagcatttt	11	15	9	6	0	1	3	0	2	1	2	1	4	1	3	0	1	3	4	0	1	4	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:164466133G>A	uc002uck.1	-	3	2520	c.2209C>T	c.(2209-2211)CAG>TAG	p.Q737*		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	737						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						ATGCTAGGCTGAATCTTGCAG	0.413													27	113					0	0	0	0	A	164466133	A	A	164466133	4	1	36	1	0	0	0	0	0	1	0	0	5923	1299	45	2	74	2	FIGN	2	164466133	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1072659	164466133	78733240	141	6941											
SCN1A	6323	broad.mit.edu	37	chr2	166848631	166848631	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccagcagaggttgtaatttgGaataggcagatcatgctgtt	11	12	12	6	0	1	2	1	0	0	2	1	3	1	3	1	3	2	6	1	3	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:166848631G>C	uc010zcz.1	-	26	5139	c.5121C>G	c.(5119-5121)TTC>TTG	p.F1707L		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1718	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTGTAATTTGGAATAGGCAGA	0.468													48	239					0	0	0	0	C	166848631	C	C	166848631	3	2	36	1	0	0	0	0	1	0	0	0	13979	1165	41	2	879	2	SCN1A	2	166848631	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2382498	166848631	76350742	142	6942											
XIRP2	129446	broad.mit.edu	37	chr2	168106418	168106418	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagagattaataactgaaaGaaaacacgaacatctgaaga	22	6	8	5	1	1	6	0	2	1	4	1	8	1	6	0	0	3	0	0	0	7	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:168106418G>T	uc002udx.2	+	8	8534	c.8516G>T	c.(8515-8517)AGA>ATA	p.R2839I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R2664I|XIRP2_uc010fpq.2_Missense_Mutation_p.R2617I|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.R185I	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2664					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATAACTGAAAGAAAACACGAA	0.383													4	119					0.00909568	0.00920092	1	0	T	168106418	T	T	168106418	3	4	36	1	0	0	0	0	1	0	0	0	17498	942	33	2	8546	2	XIRP2	2	168106418	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1257787	168106418	75092955	143	6943											
LRP2	4036	broad.mit.edu	37	chr2	169989122	169989122	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgaagttgggtttgtctCtggaactatctcagaagggt	8	14	14	5	0	2	2	1	1	2	1	4	3	2	3	0	4	1	2	0	4	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:169989122C>G	uc002ues.2	-	77	13903	c.13690G>C	c.(13690-13692)GAG>CAG	p.E4564Q		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4564	Cytoplasmic (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGGTTTGTCTCTGGAACTATC	0.418													4	240					0	0	0	0	G	169989122	G	G	169989122	3	3	36	1	0	0	0	0	1	0	0	0	9006	922	32	2	289	2	LRP2	2	169989122	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1882704	169989122	73210251	144	6944											
LRP2	4036	broad.mit.edu	37	chr2	170139405	170139405	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatcattagctttgcaataCtgtccacgctccaagatata	13	12	6	10	1	1	1	1	0	0	1	3	2	3	1	2	0	3	3	2	0	7	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:170139405C>G	uc002ues.2	-	10	1362	c.1149G>C	c.(1147-1149)CAG>CAC	p.Q383H	LRP2_uc010zdf.1_Missense_Mutation_p.Q383H	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	383	EGF-like 2.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTTTGCAATACTGTCCACGCT	0.403													52	197					0	0	0	0	G	170139405	G	G	170139405	3	3	36	1	0	0	0	0	1	0	0	0	9006	564	20	4	13098	4	LRP2	2	170139405	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	150283	170139405	73059968	145	6945											
OLA1	29789	broad.mit.edu	37	chr2	175006586	175006586	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttttttatctcctcctctCacagccaccttttctagttt	6	19	3	13	0	3	0	1	0	3	0	6	0	4	0	4	0	1	2	4	0	2	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:175006586C>G	uc002uih.2	-	5	702	c.516G>C	c.(514-516)GTG>GTC	p.V172V	OLA1_uc002uii.2_Silent_p.V14V|OLA1_uc010fqq.2_Silent_p.V172V|OLA1_uc002uij.2_Silent_p.V14V|OLA1_uc002uik.2_Silent_p.V142V|OLA1_uc010fqr.2_Silent_p.V172V	NM_013341	NP_037473	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1 isoform 1	172					ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			ovary(1)|breast(1)	2						CTCCTCCTCTCACAGCCACCT	0.294													29	135					0	0	0	0	G	175006586	G	G	175006586	2	3	36	1	0	0	0	0	0	0	0	1	10904	813	29	2		2	OLA1	2	175006586	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4867181	175006586	68192787	146	6946											
NFE2L2	4780	broad.mit.edu	37	chr2	178098944	178098944	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gactgaagtcaaatacttctCgacttactccaagatctata	14	12	5	10	1	3	2	1	1	2	1	5	4	4	2	1	0	2	0	1	0	7	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:178098944C>G	uc002ulh.3	-	2	656	c.101G>C	c.(100-102)CGA>CCA	p.R34P	NFE2L2_uc002ulg.3_Missense_Mutation_p.R18P|NFE2L2_uc010zfa.1_Missense_Mutation_p.R18P|NFE2L2_uc002uli.3_Missense_Mutation_p.R18P|NFE2L2_uc010fra.2_Missense_Mutation_p.R18P|NFE2L2_uc010frb.2_Missense_Mutation_p.R18P	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	34					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AAATACTTCTCGACTTACTCC	0.373			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			34	70					0	0	0	0	G	178098944	G	G	178098944	3	3	36	1	0	0	0	0	1	0	0	0	10422	884	31	3	1732	3	NFE2L2	2	178098944	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3092358	178098944	65100429	147	6947											
TTC30A	92104	broad.mit.edu	37	chr2	178482760	178482760	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtcatgcccacacctagctCaggatgctggcggatgccac	8	7	12	14	1	2	0	2	0	0	0	2	2	2	2	3	4	4	2	3	4	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:178482760C>G	uc002ulo.2	-	1	935	c.670G>C	c.(670-672)GAG>CAG	p.E224Q		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	224					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			ACACCTAGCTCAGGATGCTGG	0.522													30	71					0	0	0	0	G	178482760	G	G	178482760	3	3	36	1	0	0	0	0	1	0	0	0	16766	835	29	2	1331	2	TTC30A	2	178482760	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	383816	178482760	64716613	148	6948											
RBM45	129831	broad.mit.edu	37	chr2	178977396	178977396	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacacacctgagtcggtgctGagggagcgcttctcgccttt	6	11	12	12	3	1	2	0	2	1	0	3	3	1	3	2	2	3	2	2	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:178977396G>C	uc002ulv.2	+	1	215	c.123G>C	c.(121-123)CTG>CTC	p.L41L		NM_152945	NP_694453	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	41	RRM 1.				cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			AGTCGGTGCTGAGGGAGCGCT	0.627											OREG0015102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	91					0	0	0	0	C	178977396	C	C	178977396	2	2	36	1	0	0	0	0	0	0	0	1	13204	1277	45	2		2	RBM45	2	178977396	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	494636	178977396	64221977	149	6949											
OSBPL6	114880	broad.mit.edu	37	chr2	179201157	179201157	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagagatggacaggtgtgcaGaaggttagttcttgcccagt	11	10	14	6	0	1	2	0	0	1	2	1	4	1	3	1	3	2	3	1	3	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:179201157G>A	uc002ulx.2	+	9	1165	c.787G>A	c.(787-789)GAA>AAA	p.E263K	OSBPL6_uc002ulw.2_Missense_Mutation_p.E263K|OSBPL6_uc002uly.2_Missense_Mutation_p.E263K|OSBPL6_uc010zfe.1_Missense_Mutation_p.E263K|OSBPL6_uc002ulz.2_Missense_Mutation_p.E263K|OSBPL6_uc002uma.2_Missense_Mutation_p.E242K	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	263					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CAGGTGTGCAGAAGGTTAGTT	0.493													51	121					0	0	0	0	A	179201157	A	A	179201157	3	1	36	1	0	0	0	0	1	0	0	0	11335	943	33	2	856	2	OSBPL6	2	179201157	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	223761	179201157	63998216	150	6950											
TTN	7273	broad.mit.edu	37	chr2	179463706	179463706	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtcacaggagagcctccatCatattctggctcttcccagt	8	12	8	13	0	4	1	2	0	2	1	6	2	6	1	3	2	1	1	3	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:179463706C>T	uc010zfg.1	-	240	49251	c.49027G>A	c.(49027-49029)GAT>AAT	p.D16343N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D10038N|TTN_uc010zfi.1_Missense_Mutation_p.D9971N|TTN_uc010zfj.1_Missense_Mutation_p.D9846N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17270							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGCCTCCATCATATTCTGGC	0.463													12	32					0	0	0	0	T	179463706	T	T	179463706	3	4	36	1	0	0	0	0	1	0	0	0	16803	826	29	2	51250	2	TTN	2	179463706	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	262549	179463706	63735667	151	6951											
TTN	7273	broad.mit.edu	37	chr2	179487426	179487426	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcgggaaagttcacactCaaatcgagccatttcttttt	10	15	6	10	2	4	0	2	0	2	0	6	2	4	1	1	1	1	1	1	1	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:179487426C>T	uc010zfg.1	-	192	37404	c.37180G>A	c.(37180-37182)GAG>AAG	p.E12394K	TTN_uc010zfh.1_Missense_Mutation_p.E6089K|TTN_uc010zfi.1_Missense_Mutation_p.E6022K|TTN_uc010zfj.1_Missense_Mutation_p.E5897K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13321							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTCACACTCAAATCGAGCC	0.373													13	12					0	0	0	0	T	179487426	T	T	179487426	3	4	36	1	0	0	0	0	1	0	0	0	16803	835	29	2	63289	2	TTN	2	179487426	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	23720	179487426	63711947	152	6952											
TTN	7273	broad.mit.edu	37	chr2	179616570	179616570	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctacatgtaaaaacaaccggTtcaccctctaaaacatattt	16	11	3	11	1	2	0	1	0	1	0	2	0	2	0	2	1	4	2	2	1	8	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:179616570T>C	uc002unb.2	-	46	10781	c.10557A>G	c.(10555-10557)GAA>GAG	p.E3519E	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAACAACCGGTTCACCCTCTA	0.373													48	174					0	0	0	0	C	179616570	C	C	179616570	2	2	36	1	0	0	0	0	0	0	0	1	16803	1722	60	5		5	TTN	2	179616570	Silent	SNP	T	TCGA-CN-4723-01A-01D-1434-08	129144	179616570	63582803	153	6953											
TTN	7273	broad.mit.edu	37	chr2	179639765	179639765	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggaagtgaacctttctgtCagagtgcatcctgtatttat	10	14	10	7	0	2	2	1	1	1	1	3	4	3	3	2	1	2	2	2	1	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:179639765C>G	uc010zfg.1	-	29	6897	c.6673G>C	c.(6673-6675)GAC>CAC	p.D2225H	TTN_uc010zfh.1_Missense_Mutation_p.D2179H|TTN_uc010zfi.1_Missense_Mutation_p.D2179H|TTN_uc010zfj.1_Missense_Mutation_p.D2179H|TTN_uc002unb.2_Missense_Mutation_p.D2225H|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2225							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTTCTGTCAGAGTGCATC	0.408													28	99					0	0	0	0	G	179639765	G	G	179639765	3	3	36	1	0	0	0	0	1	0	0	0	16803	826	29	2	104651	2	TTN	2	179639765	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	23195	179639765	63559608	154	6954											
TTN	7273	broad.mit.edu	37	chr2	179650577	179650577	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcaggtatagactcacctGtgatgatatgtgcattccct	10	12	9	10	0	1	3	1	2	0	1	2	3	2	3	2	1	2	3	2	1	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:179650577G>A	uc010zfg.1	-	14	2592	c.2368C>T	c.(2368-2370)CAG>TAG	p.Q790*	TTN_uc010zfh.1_Nonsense_Mutation_p.Q744*|TTN_uc010zfi.1_Nonsense_Mutation_p.Q744*|TTN_uc010zfj.1_Nonsense_Mutation_p.Q744*|TTN_uc002unb.2_Nonsense_Mutation_p.Q790*|TTN_uc010frg.1_Nonsense_Mutation_p.Q372*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	790							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGACTCACCTGTGATGATATG	0.438													33	68					0	0	0	0	A	179650577	A	A	179650577	4	1	36	1	0	0	0	0	0	1	0	0	16803	1386	48	4	109016	4	TTN	2	179650577	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	10812	179650577	63548796	155	6955											
COL3A1	1281	broad.mit.edu	37	chr2	189864098	189864098	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagctggtccccctggtcccGaaggaggaaaggtaactcca	10	6	13	12	1	0	0	0	0	0	0	3	4	3	2	4	5	2	2	4	5	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:189864098G>A	uc002uqj.1	+	30	2227	c.2110G>A	c.(2110-2112)GAA>AAA	p.E704K		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	704	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCCTGGTCCCGAAGGAGGAAA	0.483													10	35					0	0	0	0	A	189864098	A	A	189864098	3	1	36	1	0	0	0	0	1	0	0	0	3703	1059	37	1	2228	1	COL3A1	2	189864098	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	10213521	189864098	53335275	156	6956											
MSTN	2660	broad.mit.edu	37	chr2	190927053	190927053	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggacatcatactgatcaatCagttcccggagtggaggagc	11	9	12	9	1	3	1	3	1	0	0	4	5	4	5	1	4	2	1	1	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:190927053C>G	uc002urp.2	-	1	403	c.270G>C	c.(268-270)CTG>CTC	p.L90L		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	90					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			ACTGATCAATCAGTTCCCGGA	0.438													11	126					0	0	0	0	G	190927053	G	G	190927053	2	3	36	1	0	0	0	0	0	0	0	1	9946	813	29	2		2	MSTN	2	190927053	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1062955	190927053	52272320	157	6957											
STAT4	6775	broad.mit.edu	37	chr2	191929550	191929550	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taccagttctgaagctggtcGagcccattgtggagtggacc	8	10	13	10	1	1	1	0	1	1	0	2	4	1	3	3	3	3	2	3	3	2	3	rs138111228	by1000genomes	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:191929550G>A	uc002usm.1	-	8	1019	c.765C>T	c.(763-765)CTC>CTT	p.L255L	STAT4_uc002usn.1_Silent_p.L255L|STAT4_uc010zgk.1_Silent_p.L100L|STAT4_uc002uso.2_Silent_p.L255L	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	255					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GAAGCTGGTCGAGCCCATTGT	0.502													73	262					0	0	0	0	A	191929550	A	A	191929550	2	1	36	1	0	0	0	0	0	0	0	1	15333	1045	37	1		1	STAT4	2	191929550	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1002497	191929550	51269823	158	6958											
DNAH7	56171	broad.mit.edu	37	chr2	196661353	196661353	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtggcaaggtgacaattctGaagaacaacccatgttcctt	12	10	10	9	0	1	3	0	2	1	1	2	3	2	3	2	3	2	2	2	3	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:196661353G>A	uc002utj.3	-	56	10563	c.10462C>T	c.(10462-10464)CAG>TAG	p.Q3488*	DNAH7_uc002uti.3_5'Flank	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3488	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGACAATTCTGAAGAACAACC	0.418													20	71					0	0	0	0	A	196661353	A	A	196661353	4	1	36	1	0	0	0	0	0	1	0	0	4628	1299	45	2	1652	2	DNAH7	2	196661353	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4731803	196661353	46538020	159	6959											
CFLAR	8837	broad.mit.edu	37	chr2	202025277	202025277	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcccgagcaccgagactacGacagctttgtgtgtgtcctg	7	10	12	12	3	0	1	0	0	0	1	1	4	1	1	3	0	4	2	3	0	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:202025277G>A	uc002uxb.3	+	9	1368	c.916G>A	c.(916-918)GAC>AAC	p.D306N	CFLAR_uc010zhk.1_Missense_Mutation_p.D210N|CFLAR_uc002uxc.3_Missense_Mutation_p.D271N|CFLAR_uc010zhl.1_Missense_Mutation_p.D210N|CFLAR_uc010fsw.1_RNA|CFLAR_uc002uxd.3_Missense_Mutation_p.D306N|CFLAR_uc002uxf.2_Missense_Mutation_p.D306N|CFLAR_uc010fsy.2_Intron|CFLAR_uc010fsx.2_Intron|CFLAR_uc010zhm.1_Missense_Mutation_p.D210N|CFLAR_uc010fsz.2_Missense_Mutation_p.D61N|CFLAR_uc002uxg.2_Missense_Mutation_p.D61N|uc002uxh.1_5'Flank	NM_003879	NP_003870	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator isoform	306	Interaction with caspase-3.|Interaction with TRAF1 and TRAF2.|Not proteolytically processed and involved in apoptosis inhibition.|Caspase.|Interaction with caspase-8 subunits p18 and p10.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding				0						CCGAGACTACGACAGCTTTGT	0.527													61	219					0	0	0	0	A	202025277	A	A	202025277	3	1	36	1	0	0	0	0	1	0	0	0	3307	1058	37	1	1010	1	CFLAR	2	202025277	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5363924	202025277	41174096	160	6960											
CYP20A1	57404	broad.mit.edu	37	chr2	204143351	204143351	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ataaaagaacgaaaaggaagGaacttcagtcaacatatttt	20	9	7	5	1	2	1	2	0	0	1	2	4	2	3	0	2	3	0	0	2	9	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:204143351G>T	uc002uzv.3	+	7	1357	c.735G>T	c.(733-735)AGG>AGT	p.R245S	CYP20A1_uc002uzx.3_Missense_Mutation_p.R143S|CYP20A1_uc010zif.1_Missense_Mutation_p.R253S|CYP20A1_uc002uzy.3_Missense_Mutation_p.R143S|CYP20A1_uc002uzw.3_RNA|CYP20A1_uc010ftw.2_5'UTR	NM_177538	NP_803882	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A,	245						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0						GAAAAGGAAGGAACTTCAGTC	0.318													6	41					1.6384e-10	1.70818e-10	1	0	T	204143351	T	T	204143351	3	4	36	1	0	0	0	0	1	0	0	0	4169	1165	41	2	761	2	CYP20A1	2	204143351	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2118074	204143351	39056022	161	6961											
ADAM23	8745	broad.mit.edu	37	chr2	207413038	207413038	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaccagtggccctttctctCtgaattacagtggttgaaaa	10	13	9	9	0	2	3	0	3	2	0	3	3	2	3	2	2	1	1	2	2	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:207413038C>T	uc002vbq.2	+	8	1050	c.827C>T	c.(826-828)TCT>TTT	p.S276F	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	276					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		CCCTTTCTCTCTGAATTACAG	0.388													32	86					0	0	0	0	T	207413038	T	T	207413038	3	4	36	1	0	0	0	0	1	0	0	0	245	913	32	2	857	2	ADAM23	2	207413038	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3269687	207413038	35786335	162	6962											
FAM119A	151194	broad.mit.edu	37	chr2	208477997	208477997	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttctaaatatatgatatCagcaccaagtatcaggtcaa	15	13	5	8	0	5	1	3	1	2	0	5	1	5	1	1	1	1	2	1	1	8	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:208477997C>T	uc002vcf.2	-	4	590	c.430G>A	c.(430-432)GAT>AAT	p.D144N	FAM119A_uc002vce.2_Intron|FAM119A_uc010fuk.1_Missense_Mutation_p.D144N|FAM119A_uc002vcg.3_Missense_Mutation_p.D144N	NM_145280	NP_660323	Q8WXB1	MT21A_HUMAN	hypothetical protein LOC151194	144						integral to membrane	methyltransferase activity				0				LUSC - Lung squamous cell carcinoma(261;0.0705)|Epithelial(149;0.131)|Lung(261;0.135)		TATATGATATCAGCACCAAGT	0.393													56	122					0	0	0	0	T	208477997	T	T	208477997	3	4	36	1	0	0	0	0	1	0	0	0	5441	826	29	2	230	2	FAM119A	2	208477997	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1064959	208477997	34721376	163	6963											
CPS1	1373	broad.mit.edu	37	chr2	211518779	211518779	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgctgacaaaatttgttGaaggggcccgagaagtagaa	13	9	14	5	1	0	4	0	2	0	2	0	5	0	4	1	3	1	3	1	3	6	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:211518779G>C	uc002vee.3	+	29	3643	c.3511G>C	c.(3511-3513)GAA>CAA	p.E1171Q	CPS1_uc010fur.2_Missense_Mutation_p.E1177Q|CPS1_uc010fus.2_Missense_Mutation_p.E720Q	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1171	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AAAATTTGTTGAAGGGGCCCG	0.438													21	99					0	0	0	0	C	211518779	C	C	211518779	3	2	36	1	0	0	0	0	1	0	0	0	3838	1291	45	2	3647	2	CPS1	2	211518779	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3040782	211518779	31680594	164	6964											
ERBB4	2066	broad.mit.edu	37	chr2	212530143	212530143	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccctgtaagccatctggacaTttttccacacagtttgggcc	8	12	8	13	0	1	0	0	0	1	0	2	1	2	1	4	2	1	2	4	2	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:212530143T>C	uc002veg.1	-	15	1874	c.1776A>G	c.(1774-1776)AAA>AAG	p.K592K	ERBB4_uc002veh.1_Silent_p.K592K|ERBB4_uc010zji.1_Silent_p.K592K|ERBB4_uc010zjj.1_Silent_p.K592K|ERBB4_uc010fut.1_Silent_p.K592K	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	592	Extracellular (Potential).|Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CATCTGGACATTTTTCCACAC	0.433										TSP Lung(8;0.080)			28	85					0	0	0	0	C	212530143	C	C	212530143	2	2	36	1	0	0	0	0	0	0	0	1	5233	1490	52	5		5	ERBB4	2	212530143	Silent	SNP	T	TCGA-CN-4723-01A-01D-1434-08	1011364	212530143	30669230	165	6965											
RNF25	64320	broad.mit.edu	37	chr2	219529908	219529908	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggggttcaggggctgctttCagtgaggcaagatcatacac	9	10	14	8	0	3	2	3	1	0	1	3	2	3	2	0	5	2	4	0	5	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:219529908C>G	uc002vit.2	-	8	724	c.636G>C	c.(634-636)CTG>CTC	p.L212L	RNF25_uc010fvw.2_Silent_p.L100L	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	212					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGCTGCTTTCAGTGAGGCAA	0.478													32	71					0	0	0	0	G	219529908	G	G	219529908	2	3	36	1	0	0	0	0	0	0	0	1	13550	813	29	2		2	RNF25	2	219529908	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6999765	219529908	23669465	166	6966											
STK36	27148	broad.mit.edu	37	chr2	219538430	219538430	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgagagattgaaataatgcGgggtctgcggcatcccaaca	13	7	12	9	3	1	2	0	1	1	1	2	4	2	2	1	3	3	1	1	3	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:219538430G>A	uc002viu.2	+	3	433	c.167G>A	c.(166-168)CGG>CAG	p.R56Q	STK36_uc002viv.2_Missense_Mutation_p.R56Q|RNF25_uc002vit.2_5'Flank|RNF25_uc010fvw.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	56	Protein kinase.				cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GAAATAATGCGGGGTCTGCGG	0.498													14	61					0	0	0	0	A	219538430	A	A	219538430	3	1	36	1	0	0	0	0	1	0	0	0	15368	1116	39	1	173	1	STK36	2	219538430	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	8522	219538430	23660943	167	6967											
SPEG	10290	broad.mit.edu	37	chr2	220309772	220309772	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gccgctggtgcgggcatctcGagctaatctggtgggcgcaa	6	8	16	11	4	2	0	0	0	2	0	3	1	2	0	1	4	2	4	1	4	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:220309772G>C	uc010fwg.2	+	3	704	c.704G>C	c.(703-705)CGA>CCA	p.R235P	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Intron|SPEG_uc002vln.1_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	235					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CGGGCATCTCGAGCTAATCTG	0.701													4	8					0	0	0	0	C	220309772	C	C	220309772	3	2	36	1	0	0	0	0	1	0	0	0	15102	1058	37	3	714	3	SPEG	2	220309772	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	771342	220309772	22889601	168	6968											
FARSB	10056	broad.mit.edu	37	chr2	223489148	223489148	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccatcacctatgacttctGattttaaatacatcctggtc	10	15	4	12	0	2	2	1	2	1	0	5	2	4	2	3	1	1	0	3	1	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:223489148G>A	uc002vne.1	-	12	1048	c.1013C>T	c.(1012-1014)TCA>TTA	p.S338L	FARSB_uc010zlq.1_Missense_Mutation_p.S358L|FARSB_uc002vnf.1_Missense_Mutation_p.S239L	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	338	B5.				phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	TATGACTTCTGATTTTAAATA	0.353													19	84					0	0	0	0	A	223489148	A	A	223489148	3	1	36	1	0	0	0	0	1	0	0	0	5712	1294	45	2	780	2	FARSB	2	223489148	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3179376	223489148	19710225	169	6969											
COL4A3	1285	broad.mit.edu	37	chr2	228128542	228128542	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccctggatggccaggcctGaaaggaagtaaaggggaacg	12	4	16	9	1	0	1	0	1	0	0	0	4	0	4	4	6	1	1	4	6	5	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:228128542G>C	uc002vom.1	+	21	1359	c.1197G>C	c.(1195-1197)CTG>CTC	p.L399L	COL4A3_uc002von.1_Silent_p.L399L|COL4A3_uc002voo.1_Silent_p.L399L|COL4A3_uc002vop.1_Silent_p.L399L|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	399	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCCAGGCCTGAAAGGAAGTA	0.517													9	44					0	0	0	0	C	228128542	C	C	228128542	2	2	36	1	0	0	0	0	0	0	0	1	3706	1277	45	2		2	COL4A3	2	228128542	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4639394	228128542	15070831	170	6970											
KCNJ13	3769	broad.mit.edu	37	chr2	233635840	233635840	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcaccattcatctcagccAgaacataccagagcactgca	14	7	6	14	0	3	2	3	0	1	2	4	3	3	2	3	0	5	2	3	0	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:233635840A>G	uc002vto.2	-	1	276	c.233T>C	c.(232-234)CTG>CCG	p.L78P	GIGYF2_uc010zmj.1_Intron|GIGYF2_uc002vtg.2_Intron|GIGYF2_uc002vtj.3_Intron|GIGYF2_uc002vti.3_Intron|GIGYF2_uc002vtk.3_Intron|GIGYF2_uc002vth.3_Intron|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc010zml.1_Intron|KCNJ13_uc002vtn.2_Intron|KCNJ13_uc002vtp.2_Missense_Mutation_p.L78P	NM_002242	NP_002233	O60928	IRK13_HUMAN	potassium inwardly-rectifying channel J13	78	Helical; Name=M1; (By similarity).					voltage-gated potassium channel complex	inward rectifier potassium channel activity				0		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0306)|Lung NSC(271;0.0908)		Epithelial(121;5.9e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0617)		CATCTCAGCCAGAACATACCA	0.468													20	73					0	0	0	0	G	233635840	G	G	233635840	3	3	36	1	0	0	0	0	1	0	0	0	8086	188	7	5	857	5	KCNJ13	2	233635840	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	5507298	233635840	9563533	171	6971											
INPP5D	3635	broad.mit.edu	37	chr2	234094512	234094512	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtcaagagtcaggaaggaGaaaatgaagaaggaagtgag	18	6	15	2	0	2	5	2	2	0	3	2	8	2	7	0	3	0	0	0	3	7	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:234094512G>C	uc010zmo.1	+	20	2452	c.2299G>C	c.(2299-2301)GAA>CAA	p.E767Q	INPP5D_uc010zmp.1_Missense_Mutation_p.E766Q	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	767					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCAGGAAGGAGAAAATGAAGA	0.478													9	25					0	0	0	0	C	234094512	C	C	234094512	3	2	36	1	0	0	0	0	1	0	0	0	7795	943	33	2	1889	2	INPP5D	2	234094512	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	458672	234094512	9104861	172	6972											
UGT1A7	54577	broad.mit.edu	37	chr2	234591192	234591192	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcagacgccatgactttCaaggagagagtatggaacca	13	9	10	9	1	2	3	2	1	1	2	3	6	2	5	2	2	1	1	2	2	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:234591192C>T	uc002vut.2	+	1	609	c.609C>T	c.(607-609)TTC>TTT	p.F203F	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Silent_p.F203F	NM_019077	NP_061950	Q9HAW7	UD17_HUMAN	UDP glycosyltransferase 1 family, polypeptide A7	203					drug metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	drug binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CCATGACTTTCAAGGAGAGAG	0.428													105	251					0	0	0	0	T	234591192	T	T	234591192	2	4	36	1	0	0	0	0	0	0	0	1	17018	825	29	2		2	UGT1A7	2	234591192	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	496680	234591192	8608181	173	6973											
UGT1A1	54658	broad.mit.edu	37	chr2	234669410	234669410	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttccttccttgcagccccatCgtggcccagtacctgtctct	4	13	7	17	1	1	0	0	0	1	0	5	0	3	0	6	1	3	2	6	1	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:234669410C>T	uc002vvb.2	+	1	492	c.477C>T	c.(475-477)ATC>ATT	p.I159I	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Silent_p.I159I	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	159					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	GCAGCCCCATCGTGGCCCAGT	0.557													75	156					0	0	0	0	T	234669410	T	T	234669410	2	4	36	1	0	0	0	0	0	0	0	1	17012	874	31	1		1	UGT1A1	2	234669410	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	78218	234669410	8529963	174	6974											
AGAP1	116987	broad.mit.edu	37	chr2	236949416	236949416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccggctgacgagccagagcGaggccatggccctgcagtcg	7	4	15	15	4	0	2	0	1	0	1	1	4	0	2	4	3	3	2	4	3	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:236949416G>A	uc002vvs.2	+	15	2417	c.1822G>A	c.(1822-1824)GAG>AAG	p.E608K	AGAP1_uc002vvt.2_Missense_Mutation_p.E555K	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	608					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						GAGCCAGAGCGAGGCCATGGC	0.602													15	58					0	0	0	0	A	236949416	A	A	236949416	3	1	36	1	0	0	0	0	1	0	0	0	366	1059	37	1	1880	1	AGAP1	2	236949416	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2280006	236949416	6249957	175	6975											
ASB1	51665	broad.mit.edu	37	chr2	239342304	239342304	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcggggacctccagaccctCaggagcctattgcaagagga	10	6	13	12	1	1	2	1	0	0	2	3	5	2	5	4	4	2	1	4	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:239342304C>T	uc002vyg.2	+	2	245	c.159C>T	c.(157-159)CTC>CTT	p.L53L		NM_001040445	NP_001035535	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box-containing protein	53	ANK 1.				intracellular signal transduction|negative regulation of cytokine biosynthetic process						0		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		TCCAGACCCTCAGGAGCCTAT	0.607													24	64					0	0	0	0	T	239342304	T	T	239342304	2	4	36	1	0	0	0	0	0	0	0	1	1015	813	29	2		2	ASB1	2	239342304	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2392888	239342304	3857069	176	6976											
CAPN10	11132	broad.mit.edu	37	chr2	241534074	241534074	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagggagtttgacgagctCaccgttggctacccggtcac	7	9	12	13	3	3	1	3	1	0	0	3	3	3	2	2	3	2	4	2	3	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr2:241534074C>G	uc002vzk.1	+	6	1129	c.945C>G	c.(943-945)CTC>CTG	p.L315L	CAPN10_uc010zoh.1_Silent_p.L315L|CAPN10_uc002vzl.1_Silent_p.L315L|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Silent_p.L187L|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	315	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		TTGACGAGCTCACCGTTGGCT	0.642													20	115					0	0	0	0	G	241534074	G	G	241534074	2	3	36	1	0	0	0	0	0	0	0	1	2635	813	29	2		2	CAPN10	2	241534074	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2191770	241534074	1665299	177	6977											
SRGAP3	9901	broad.mit.edu	37	chr3	9074387	9074387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttatggctatacactgagaGaggcctaggtctcctcattt	9	14	9	9	0	2	2	1	1	1	1	3	3	2	2	2	3	1	1	2	3	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:9074387G>A	uc003brf.1	-	12	2162	c.1486C>T	c.(1486-1488)CTC>TTC	p.L496F	SRGAP3_uc003brg.1_Intron|SRGAP3_uc003bri.1_RNA	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	496	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TACACTGAGAGAGGCCTAGGT	0.468			T	RAF1	pilocytic astrocytoma								45	40					0	0	0	0	A	9074387	A	A	9074387	3	1	36	1	0	0	0	0	1	0	0	0	15213	942	33	2	1892	2	SRGAP3	3	9074387	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08		9074387	188948043	178	6978											
BRPF1	7862	broad.mit.edu	37	chr3	9783766	9783766	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcctttcctcatcctccttCgcaaaaccttggagcagctc	7	12	5	17	1	1	0	1	0	0	0	7	1	5	1	5	1	3	3	5	1	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:9783766C>T	uc003bse.2	+	6	2311	c.1912C>T	c.(1912-1914)CGC>TGC	p.R638C	BRPF1_uc003bsf.2_Missense_Mutation_p.R638C|BRPF1_uc003bsg.2_Missense_Mutation_p.R638C|BRPF1_uc011ati.1_Missense_Mutation_p.R638C	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	638	Required for RUNX1 and RUNX2 transcriptional activation.|Interaction with MEAF6 and ING5.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					CATCCTCCTTCGCAAAACCTT	0.522													38	48					0	0	0	0	T	9783766	T	T	9783766	3	4	36	1	0	0	0	0	1	0	0	0	1525	884	31	1	1930	1	BRPF1	3	9783766	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	709379	9783766	188238664	179	6979											
TATDN2	9797	broad.mit.edu	37	chr3	10291085	10291085	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gacgatgtggcttgctcgcgGaggttatcctggggctcatc	5	11	15	10	3	1	0	1	0	0	0	4	3	2	1	1	5	1	4	1	5	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:10291085G>A	uc003bvg.2	+	2	782	c.201G>A	c.(199-201)CGG>CGA	p.R67R	TATDN2_uc003bvf.2_Silent_p.R67R|TATDN2_uc011atr.1_Silent_p.R67R|TATDN2_uc011ats.1_RNA|TATDN2_uc011att.1_RNA	NM_014760	NP_055575	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	67						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			pancreas(2)	2						CTTGCTCGCGGAGGTTATCCT	0.652													61	70					0	0	0	0	A	10291085	A	A	10291085	2	1	36	1	0	0	0	0	0	0	0	1	15658	1161	41	2		2	TATDN2	3	10291085	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	507319	10291085	187731345	180	6980											
PLCL2	23228	broad.mit.edu	37	chr3	17056235	17056235	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaaggagctgtgtggcctCtcctctgtggccaatctcat	6	13	10	12	0	4	0	2	0	3	0	6	1	4	1	3	3	1	1	3	3	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:17056235C>T	uc011awc.1	+	6	2931	c.2826C>T	c.(2824-2826)CTC>CTT	p.L942L	PLCL2_uc011awd.1_Silent_p.L824L	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	950					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						TGTGTGGCCTCTCCTCTGTGG	0.488													122	161					0	0	0	0	T	17056235	T	T	17056235	2	4	36	1	0	0	0	0	0	0	0	1	12095	900	32	2		2	PLCL2	3	17056235	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6765150	17056235	180966195	181	6981											
CSRNP1	64651	broad.mit.edu	37	chr3	39184825	39184825	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtcacaagaagacaagctGagatccactgagctactccg	14	6	10	11	1	1	4	1	2	0	3	3	6	3	4	2	0	3	2	2	0	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:39184825G>C	uc003cjg.2	-	5	1705	c.1491C>G	c.(1489-1491)CTC>CTG	p.L497L	CSRNP1_uc003cjh.2_Silent_p.L497L	NM_033027	NP_149016	Q96S65	CSRN1_HUMAN	AXIN1 up-regulated 1	497					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(4)|skin(1)	5						AAGACAAGCTGAGATCCACTG	0.552													28	33					0	0	0	0	C	39184825	C	C	39184825	2	2	36	1	0	0	0	0	0	0	0	1	3980	1277	45	2		2	CSRNP1	3	39184825	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	22128590	39184825	158837605	182	6982											
NBEAL2	23218	broad.mit.edu	37	chr3	47045664	47045664	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacttgagctcttctttatCgatcaggccaactacttcct	8	14	6	13	1	3	1	1	1	2	0	5	2	4	1	2	1	3	2	2	1	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:47045664C>T	uc003cqp.2	+	37	6158	c.5979C>T	c.(5977-5979)ATC>ATT	p.I1993I	NBEAL2_uc010hjm.1_Silent_p.I1370I|NBEAL2_uc010hjn.1_Silent_p.I389I|NBEAL2_uc010hjo.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1993							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TCTTCTTTATCGATCAGGCCA	0.602													209	187					0	0	0	0	T	47045664	T	T	47045664	2	4	36	1	0	0	0	0	0	0	0	1	10242	874	31	1		1	NBEAL2	3	47045664	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	7860839	47045664	150976766	183	6983											
USP19	10869	broad.mit.edu	37	chr3	49149116	49149116	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctggagctcaggtggctGaatggggtctctctcgctgt	5	11	15	10	1	3	1	1	1	2	0	5	2	3	2	0	5	2	4	0	5	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:49149116G>T	uc003cwd.1	-	20	2886	c.2725C>A	c.(2725-2727)CAG>AAG	p.Q909K	USP19_uc003cwa.2_Missense_Mutation_p.Q717K|USP19_uc003cvz.3_Missense_Mutation_p.Q1012K|USP19_uc011bcg.1_Missense_Mutation_p.Q1000K|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_Missense_Mutation_p.Q667K|USP19_uc011bch.1_Missense_Mutation_p.Q1010K	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	909	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCAGGTGGCTGAATGGGGTCT	0.672													55	52					6.3091e-27	6.7503e-27	1	0	T	49149116	T	T	49149116	3	4	36	1	0	0	0	0	1	0	0	0	17118	1299	45	2	1259	2	USP19	3	49149116	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2103452	49149116	148873314	184	6984											
NICN1	84276	broad.mit.edu	37	chr3	49466543	49466543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccaccaggcttgctcacctCgaagggagcgacgctgggga	8	5	14	14	3	1	0	1	0	0	0	2	4	1	2	3	4	2	3	3	4	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:49466543C>T	uc003cwz.1	-	1	215	c.130G>A	c.(130-132)GAG>AAG	p.E44K	NICN1_uc003cxa.2_RNA|NICN1_uc011bcr.1_Missense_Mutation_p.E44K	NM_032316	NP_115692	Q9BSH3	NICN1_HUMAN	nicolin 1	44						microtubule|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;4.52e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TTGCTCACCTCGAAGGGAGCG	0.647													24	35					0	0	0	0	T	49466543	T	T	49466543	3	4	36	1	0	0	0	0	1	0	0	0	10467	893	31	1	535	1	NICN1	3	49466543	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	317427	49466543	148555887	185	6985											
MST1	4485	broad.mit.edu	37	chr3	49723345	49723345	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggcactggacacccttgcGggtcttgctgaccgtgccgc	4	9	13	15	3	1	1	0	1	1	0	1	2	1	2	3	3	3	2	3	3	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:49723345G>A	uc003cxg.2	-	10	1270	c.1198C>T	c.(1198-1200)CGC>TGC	p.R400C	MST1_uc011bcs.1_Silent_p.P438P	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	386	Kringle 4.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACACCCTTGCGGGTCTTGCTG	0.731													3	81					0	0	0	0	A	49723345	A	A	49723345	3	1	36	1	0	0	0	0	1	0	0	0	9943	1116	39	1	1015	1	MST1	3	49723345	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	256802	49723345	148299085	186	6986											
MST1R	4486	broad.mit.edu	37	chr3	49927430	49927430	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgggtaaggtcaaaagggtCaatgtggcggtatggtgggg	9	9	20	3	1	2	0	2	0	0	0	2	0	2	0	0	8	0	2	0	8	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:49927430C>G	uc003cxy.3	-	19	4138	c.3874G>C	c.(3874-3876)GAC>CAC	p.D1292H	MST1R_uc011bdc.1_Missense_Mutation_p.D171H	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1292	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TCAAAAGGGTCAATGTGGCGG	0.557													3	91					0	0	0	0	G	49927430	G	G	49927430	3	3	36	1	0	0	0	0	1	0	0	0	9944	826	29	2	336	2	MST1R	3	49927430	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	204085	49927430	148095000	187	6987											
RBM5	10181	broad.mit.edu	37	chr3	50145726	50145726	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggattggaatctgatgcatCatctgcatcaggtagtaaac	13	11	10	7	0	4	1	2	1	2	0	4	3	4	3	0	3	3	4	0	3	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:50145726C>G	uc003cyg.2	+	14	1329	c.1181C>G	c.(1180-1182)TCA>TGA	p.S394*	RBM5_uc011bdj.1_Nonsense_Mutation_p.S338*|RBM5_uc011bdk.1_Nonsense_Mutation_p.S222*	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	394	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCTGATGCATCATCTGCATCA	0.373													61	85					0	0	0	0	G	50145726	G	G	50145726	4	3	36	1	0	0	0	0	0	1	0	0	13208	838	29	2	1231	2	RBM5	3	50145726	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	218296	50145726	147876704	188	6988											
ALAS1	211	broad.mit.edu	37	chr3	52240616	52240616	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atttactctgattctgggaaCcatgcctccatgatccaagg	10	12	8	11	0	2	2	0	2	2	0	4	3	4	3	4	2	3	0	4	2	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:52240616C>T	uc003dcy.1	+	8	1351	c.1014C>T	c.(1012-1014)AAC>AAT	p.N338N	ALAS1_uc003dcz.1_Silent_p.N338N|ALAS1_uc011bec.1_Silent_p.N355N	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	338					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	ATTCTGGGAACCATGCCTCCA	0.438													83	111					0	0	0	0	T	52240616	T	T	52240616	2	4	36	1	0	0	0	0	0	0	0	1	484	506	18	4		4	ALAS1	3	52240616	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2094890	52240616	145781814	189	6989											
CACNA1D	776	broad.mit.edu	37	chr3	53757550	53757550	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaagcatatttcgtctctCttttcaaccggtttgattgc	7	17	6	11	2	3	1	1	1	2	0	6	1	4	1	2	1	3	2	2	1	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:53757550C>G	uc003dgv.3	+	13	1919	c.1756C>G	c.(1756-1758)CTT>GTT	p.L586V	CACNA1D_uc003dgu.3_Missense_Mutation_p.L606V|CACNA1D_uc003dgy.3_Missense_Mutation_p.L586V|CACNA1D_uc003dgw.3_Missense_Mutation_p.L253V	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	586	Helical; Name=S3 of repeat II; (Potential).|II.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TTTCGTCTCTCTTTTCAACCG	0.478													12	273					0	0	0	0	G	53757550	G	G	53757550	3	3	36	1	0	0	0	0	1	0	0	0	2553	913	32	2	1978	2	CACNA1D	3	53757550	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1516934	53757550	144264880	190	6990											
ATXN7	6314	broad.mit.edu	37	chr3	63982084	63982084	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgccaaagtgccagccgtGaacaatgtccacatgaaaca	14	7	9	11	1	0	2	0	2	0	0	1	2	1	2	4	0	5	1	4	0	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:63982084G>A	uc003dlw.3	+	12	3139	c.2586G>A	c.(2584-2586)GTG>GTA	p.V862V	ATXN7_uc003dlv.2_Silent_p.V862V|ATXN7_uc010hnv.2_Silent_p.V862V|ATXN7_uc011bfn.1_Silent_p.V717V	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	862					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		TGCCAGCCGTGAACAATGTCC	0.502													21	48					0	0	0	0	A	63982084	A	A	63982084	2	1	36	1	0	0	0	0	0	0	0	1	1217	1277	45	2		2	ATXN7	3	63982084	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	10224534	63982084	134040346	191	6991											
IMPG2	50939	broad.mit.edu	37	chr3	100976587	100976587	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctgatggcctcaccattGaaggtaactgcatagtaaac	12	11	9	9	0	1	2	1	2	0	0	1	2	1	2	2	2	4	4	2	2	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:100976587G>T	uc003duq.1	-	10	1142	c.939C>A	c.(937-939)TTC>TTA	p.F313L	IMPG2_uc011bhe.1_Missense_Mutation_p.F176L	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	313	Extracellular (Potential).|SEA 1.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CCTCACCATTGAAGGTAACTG	0.468													24	181					2.65835e-16	2.81229e-16	1	0	T	100976587	T	T	100976587	3	4	36	1	0	0	0	0	1	0	0	0	7768	1281	45	2	2826	2	IMPG2	3	100976587	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	36994503	100976587	97045843	192	6992											
BBX	56987	broad.mit.edu	37	chr3	107520004	107520004	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caactgagacagactgcaatGacaaatgctcacacaacacc	17	5	6	13	0	1	3	1	2	0	2	1	4	1	3	1	0	4	2	1	0	4	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:107520004G>C	uc010hpr.2	+	17	2941	c.2614G>C	c.(2614-2616)GAC>CAC	p.D872H	BBX_uc003dwk.3_Missense_Mutation_p.D842H|BBX_uc003dwl.3_Missense_Mutation_p.M535I|BBX_uc003dwm.3_Missense_Mutation_p.D842H|BBX_uc003dwo.3_Missense_Mutation_p.M188I	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	872					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			AGACTGCAATGACAAATGCTC	0.507													60	83					0	0	0	0	C	107520004	C	C	107520004	3	2	36	1	0	0	0	0	1	0	0	0	1345	1290	45	2	2668	2	BBX	3	107520004	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	6543417	107520004	90502426	193	6993											
BBX	56987	broad.mit.edu	37	chr3	107520042	107520042	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	accgaggtcggggagacgcgGagcagtactccagaaatgcc	11	4	15	11	4	0	2	0	0	0	2	2	5	1	3	3	4	3	2	3	4	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:107520042G>C	uc010hpr.2	+	17	2979	c.2652G>C	c.(2650-2652)CGG>CGC	p.R884R	BBX_uc003dwk.3_Silent_p.R854R|BBX_uc003dwl.3_Missense_Mutation_p.G548A|BBX_uc003dwm.3_Silent_p.R854R|BBX_uc003dwo.3_Missense_Mutation_p.G201A	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	884					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GGGAGACGCGGAGCAGTACTC	0.527													41	46					0	0	0	0	C	107520042	C	C	107520042	2	2	36	1	0	0	0	0	0	0	0	1	1345	1161	41	2		2	BBX	3	107520042	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	38	107520042	90502388	194	6994											
DZIP3	9666	broad.mit.edu	37	chr3	108326985	108326985	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaaactgagaataagctaGaaaaatcatctggtcaactg	19	8	8	6	0	3	3	2	1	1	3	3	4	3	3	0	1	3	1	0	1	8	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:108326985G>C	uc003dxd.2	+	3	504	c.82G>C	c.(82-84)GAA>CAA	p.E28Q	DZIP3_uc003dxf.1_Missense_Mutation_p.E28Q|DZIP3_uc011bhm.1_5'UTR|DZIP3_uc003dxe.1_Missense_Mutation_p.E28Q	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	28	Potential.				protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GAATAAGCTAGAAAAATCATC	0.313													39	154					0	0	0	0	C	108326985	C	C	108326985	3	2	36	1	0	0	0	0	1	0	0	0	4887	943	33	2	88	2	DZIP3	3	108326985	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	806943	108326985	89695445	195	6995											
DZIP3	9666	broad.mit.edu	37	chr3	108393015	108393015	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcagcttgccagggtgactCacatggcagcaaggtaacct	11	8	11	11	0	2	1	2	1	0	0	2	1	2	1	2	3	4	4	2	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:108393015C>G	uc003dxd.2	+	24	3102	c.2680C>G	c.(2680-2682)CAC>GAC	p.H894D	DZIP3_uc003dxf.1_Missense_Mutation_p.H894D|DZIP3_uc011bhm.1_Missense_Mutation_p.H345D	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	894					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CAGGGTGACTCACATGGCAGC	0.408													38	167					0	0	0	0	G	108393015	G	G	108393015	3	3	36	1	0	0	0	0	1	0	0	0	4887	826	29	2	2770	2	DZIP3	3	108393015	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	66030	108393015	89629415	196	6996											
MORC1	27136	broad.mit.edu	37	chr3	108746617	108746617	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtggctgctgttctgccAgtctattttgatactttatg	5	18	9	9	0	2	1	0	1	2	0	2	1	2	1	2	1	3	3	2	1	3	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:108746617A>T	uc003dxl.2	-	17	1772	c.1685T>A	c.(1684-1686)CTG>CAG	p.L562Q	MORC1_uc011bhn.1_Missense_Mutation_p.L562Q	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	562					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CTGTTCTGCCAGTCTATTTTG	0.408													10	286					0	0	0	0	T	108746617	T	T	108746617	3	4	36	1	0	0	0	0	1	0	0	0	9754	188	7	5	1317	5	MORC1	3	108746617	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	353602	108746617	89275813	197	6997											
MORC1	27136	broad.mit.edu	37	chr3	108812388	108812388	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tataaataaccagcaaagtaCctggtagaaaaatagatgtt	19	10	7	5	0	0	2	0	0	0	2	0	2	0	2	2	1	3	4	2	1	10	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:108812388C>T	uc003dxl.2	-	8	671	c.584G>A	c.(583-585)GGT>GAT	p.G195D	MORC1_uc011bhn.1_Missense_Mutation_p.G195D	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	195					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CAGCAAAGTACCTGGTAGAAA	0.348													41	51					0	0	0	0	T	108812388	T	T	108812388	3	4	36	1	0	0	0	0	1	0	0	0	9754	521	18	4	2454	4	MORC1	3	108812388	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	65771	108812388	89210042	198	6998											
CCDC52	152185	broad.mit.edu	37	chr3	113172409	113172409	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atattattcatatgtgccttGatagctgaattctgcaatgt	11	17	7	6	0	2	2	1	2	1	0	2	2	2	2	1	0	3	2	1	0	6	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:113172409G>C	uc003eag.3	-	14	2337	c.2046C>G	c.(2044-2046)ATC>ATG	p.I682M	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Missense_Mutation_p.I578M	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	682					cell division|mitosis	centriole|spindle	protein binding				0						TATGTGCCTTGATAGCTGAAT	0.418													114	155					0	0	0	0	C	113172409	C	C	113172409	3	2	36	1	0	0	0	0	1	0	0	0	2835	1280	45	2	541	2	CCDC52	3	113172409	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4360021	113172409	84850021	199	6999											
SIDT1	54847	broad.mit.edu	37	chr3	113286437	113286437	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagccgcaccttatgtccctCagaagcaaccaatgagacgg	12	6	10	13	2	1	2	1	1	0	2	2	4	2	2	4	1	3	2	4	1	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:113286437C>T	uc003eak.2	+	3	1046	c.395C>T	c.(394-396)TCA>TTA	p.S132L	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.S132L|SIDT1_uc011big.1_5'UTR	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	132	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						TTATGTCCCTCAGAAGCAACC	0.473													135	169					0	0	0	0	T	113286437	T	T	113286437	3	4	36	1	0	0	0	0	1	0	0	0	14367	838	29	2	405	2	SIDT1	3	113286437	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	114028	113286437	84735993	200	7000											
C3orf1	51300	broad.mit.edu	37	chr3	119236098	119236098	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catttcagaagtactctggtGagactgttcaggaaagaaaa	15	10	10	6	0	3	3	2	1	1	3	3	5	3	4	0	2	1	2	0	2	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:119236098G>C	uc003ecn.2	+	6	856	c.643G>C	c.(643-645)GAG>CAG	p.E215Q	C3orf1_uc003eco.2_RNA|C3orf1_uc003ecp.2_RNA	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300	215						integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		GTACTCTGGTGAGACTGTTCA	0.468													6	188					0	0	0	0	C	119236098	C	C	119236098	3	2	36	1	0	0	0	0	1	0	0	0	2216	1291	45	2	665	2	C3orf1	3	119236098	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5949661	119236098	78786332	201	7001											
PLA1A	51365	broad.mit.edu	37	chr3	119325723	119325723	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtttctcctctttgtcccttCgaatcctagctgtgggcagc	4	15	9	13	1	2	0	0	0	2	0	6	1	4	0	3	1	2	3	3	1	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:119325723C>T	uc003ecu.2	+	2	215	c.176C>T	c.(175-177)TCG>TTG	p.S59L	PLA1A_uc003ecv.2_Missense_Mutation_p.S59L|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_Intron	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	59					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						TTTGTCCCTTCGAATCCTAGC	0.507													68	364					0	0	0	0	T	119325723	T	T	119325723	3	4	36	1	0	0	0	0	1	0	0	0	12043	893	31	1	182	1	PLA1A	3	119325723	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	89625	119325723	78696707	202	7002											
GSK3B	2932	broad.mit.edu	37	chr3	119624670	119624670	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggttgtcctagtaacagctCagccaacacacagccagcag	12	7	9	13	0	1	0	1	0	0	0	2	0	2	0	3	1	6	4	3	1	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:119624670C>T	uc003edo.2	-	7	1728	c.745G>A	c.(745-747)GAG>AAG	p.E249K	GSK3B_uc003edn.2_Missense_Mutation_p.E249K	NM_001146156	NP_001139628	P49841	GSK3B_HUMAN	glycogen synthase kinase 3 beta isoform 2	249	Protein kinase.				axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding			lung(2)	2				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)	AGTAACAGCTCAGCCAACACA	0.353													276	393					0	0	0	0	T	119624670	T	T	119624670	3	4	36	1	0	0	0	0	1	0	0	0	6863	835	29	2	580	2	GSK3B	3	119624670	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	298947	119624670	78397760	203	7003											
FSTL1	11167	broad.mit.edu	37	chr3	120118774	120118774	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatctggtcatctcctcctCtgtctgggtctgggccccct	3	14	9	15	0	6	0	1	0	5	0	8	0	7	0	4	3	0	0	4	3	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:120118774C>T	uc003eds.2	-	10	1013	c.838G>A	c.(838-840)GAG>AAG	p.E280K	FSTL1_uc011bjh.1_Missense_Mutation_p.E245K	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	follistatin-like 1 precursor	280	VWFC.				BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.189)		ATCTCCTCCTCTGTCTGGGTC	0.542													11	20					0	0	0	0	T	120118774	T	T	120118774	3	4	36	1	0	0	0	0	1	0	0	0	6111	922	32	2	96	2	FSTL1	3	120118774	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	494104	120118774	77903656	204	7004											
PARP14	54625	broad.mit.edu	37	chr3	122447299	122447299	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctatacacatggaaatcattCattaattgtgcctccttcaa	13	14	4	10	0	3	0	3	0	0	0	4	1	4	1	2	1	2	0	2	1	5	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:122447299C>T	uc003efq.3	+	17	5320	c.5261C>T	c.(5260-5262)TCA>TTA	p.S1754L	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.S1471L	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1754	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		GGAAATCATTCATTAATTGTG	0.388													51	200					0	0	0	0	T	122447299	T	T	122447299	3	4	36	1	0	0	0	0	1	0	0	0	11512	838	29	2	5327	2	PARP14	3	122447299	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2328525	122447299	75575131	205	7005											
SEMA5B	54437	broad.mit.edu	37	chr3	122631079	122631079	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcccgagacagatgtcctCacctggggagggtgcggggc	7	5	17	12	2	1	2	1	0	0	2	2	4	2	3	3	5	2	0	3	5	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:122631079C>G	uc003efz.1	-	19	3140	c.2836G>C	c.(2836-2838)GAG>CAG	p.E946Q	SEMA5B_uc011bju.1_Missense_Mutation_p.E852Q|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.E946Q|SEMA5B_uc003efy.1_Intron	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	946	Extracellular (Potential).|TSP type-1 4.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CAGATGTCCTCACCTGGGGAG	0.632													24	22					0	0	0	0	G	122631079	G	G	122631079	3	3	36	1	0	0	0	0	1	0	0	0	14103	835	29	2	639	2	SEMA5B	3	122631079	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	183780	122631079	75391351	206	7006											
HEG1	57493	broad.mit.edu	37	chr3	124732246	124732246	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaaagtggggcagatgtaGatgtcgttaaggatactggt	12	10	15	4	1	0	3	0	0	0	3	1	4	0	4	0	4	1	3	0	4	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:124732246G>C	uc003ehs.3	-	6	2245	c.2177C>G	c.(2176-2178)TCT>TGT	p.S726C	HEG1_uc011bke.1_Missense_Mutation_p.S826C	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	726	Extracellular (Potential).|Ser-rich.					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GGCAGATGTAGATGTCGTTAA	0.502													42	176					0	0	0	0	C	124732246	C	C	124732246	3	2	36	1	0	0	0	0	1	0	0	0	7083	942	33	2	2016	2	HEG1	3	124732246	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2101167	124732246	73290184	207	7007											
ZNF148	7707	broad.mit.edu	37	chr3	124951513	124951513	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcacctgaaaagggaaatGagtgctgtgaatcaccaact	15	8	9	9	0	2	3	2	3	0	0	2	4	2	4	2	1	2	1	2	1	5	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:124951513G>C	uc003ehx.3	-	9	2543	c.2057C>G	c.(2056-2058)TCA>TGA	p.S686*	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Nonsense_Mutation_p.S686*|ZNF148_uc010hsa.2_Nonsense_Mutation_p.S686*|ZNF148_uc003eia.3_Nonsense_Mutation_p.S686*|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	686					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						AAAGGGAAATGAGTGCTGTGA	0.448													71	282					0	0	0	0	C	124951513	C	C	124951513	4	2	36	1	0	0	0	0	0	1	0	0	17801	1294	45	2	331	2	ZNF148	3	124951513	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	219267	124951513	73070917	208	7008											
PLXNA1	5361	broad.mit.edu	37	chr3	126736358	126736358	+	Frame_Shift_Del	DEL	C	-	-																															caccagagctgggggagcggCcggatgagctgggcttcgtc																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:126736358delC	uc003ejg.2	+	17	3302	c.3298delC	c.(3298-3300)CCGfs	p.P1100fs		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1123	Extracellular (Potential).|IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		GGGGGAGCGGCCGGATGAGCT	0.637													---	---	---								-	126736358	-	-	126736358	7	5	36	1	0	1	0	1	0	0	0	0	12174	739	26	0	3433	0	PLXNA1	3	126736358	Frame_Shift_Del	DEL	C	TCGA-CN-4723-01A-01D-1434-08	1784845	126736358	71286072	209	7009											
COL6A6	131873	broad.mit.edu	37	chr3	130281985	130281985	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaagtccttcccatttgtGaaaatgttcatcaccaaaat	13	13	4	11	0	2	1	2	1	0	0	5	1	5	1	4	0	0	1	4	0	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:130281985G>A	uc010htl.2	+	2	169	c.138G>A	c.(136-138)GTG>GTA	p.V46V		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	46	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TCCCATTTGTGAAAATGTTCA	0.473													5	343					0	0	0	0	A	130281985	A	A	130281985	2	1	36	1	0	0	0	0	0	0	0	1	3718	1277	45	2		2	COL6A6	3	130281985	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3545627	130281985	67740445	210	7010											
ATP2C1	27032	broad.mit.edu	37	chr3	130686024	130686024	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tataatcaatttggggaagtGattgttgatggtgatgttgt	10	17	13	1	0	1	3	1	3	0	0	1	4	1	4	0	3	0	2	0	3	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:130686024G>C	uc003enl.2	+	15	1380	c.1158G>C	c.(1156-1158)GTG>GTC	p.V386V	ATP2C1_uc011blg.1_Silent_p.V420V|ATP2C1_uc011blh.1_Silent_p.V381V|ATP2C1_uc011bli.1_Silent_p.V420V|ATP2C1_uc003enk.2_Silent_p.V370V|ATP2C1_uc003enm.2_Silent_p.V386V|ATP2C1_uc003enn.2_Silent_p.V370V|ATP2C1_uc003eno.2_Silent_p.V386V|ATP2C1_uc003enp.2_Silent_p.V386V|ATP2C1_uc003enq.2_Silent_p.V386V|ATP2C1_uc003enr.2_Silent_p.V386V|ATP2C1_uc003ens.2_Silent_p.V386V|ATP2C1_uc003ent.2_Silent_p.V386V|ATP2C1_uc003enu.2_Silent_p.V64V	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	386	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TTGGGGAAGTGATTGTTGATG	0.358									Hailey-Hailey_disease				99	495					0	0	0	0	C	130686024	C	C	130686024	2	2	36	1	0	0	0	0	0	0	0	1	1145	1277	45	2		2	ATP2C1	3	130686024	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	404039	130686024	67336406	211	7011											
CPNE4	131034	broad.mit.edu	37	chr3	131404721	131404721	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgaagatgactcttacctCagttcggtgcaccagctgct	8	11	10	12	1	2	3	1	2	1	1	3	3	2	3	2	1	4	5	2	1	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:131404721C>T	uc003eok.2	-	6	1024	c.589G>A	c.(589-591)GAG>AAG	p.E197K	CPNE4_uc011blq.1_Missense_Mutation_p.E215K|CPNE4_uc003eol.2_Missense_Mutation_p.E215K|CPNE4_uc003eom.2_Missense_Mutation_p.E197K	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	197	C2 2.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ACTCTTACCTCAGTTCGGTGC	0.373													15	85					0	0	0	0	T	131404721	T	T	131404721	3	4	36	1	0	0	0	0	1	0	0	0	3829	835	29	2	1128	2	CPNE4	3	131404721	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	718697	131404721	66617709	212	7012											
ESYT3	83850	broad.mit.edu	37	chr3	138178802	138178802	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccagttgcagggcaccctgCgggtcatcctggagcccctc	5	8	12	16	1	1	0	1	0	0	0	4	1	3	1	5	3	3	3	5	3	0	1	rs62282904		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:138178802C>T	uc003esk.2	+	6	890	c.664C>T	c.(664-666)CGG>TGG	p.R222W	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	222						integral to membrane|plasma membrane					0						GGGCACCCTGCGGGTCATCCT	0.632													53	148					0	0	0	0	T	138178802	T	T	138178802	3	4	36	1	0	0	0	0	1	0	0	0	5290	759	27	1	686	1	ESYT3	3	138178802	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6774081	138178802	59843628	213	7013											
XRN1	54464	broad.mit.edu	37	chr3	142151555	142151555	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctcgaggagccacaccatCtacagccataaagaacactt	14	7	7	13	1	1	1	0	0	1	1	2	3	1	2	3	1	5	1	3	1	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:142151555C>G	uc003eus.2	-	2	323	c.256G>C	c.(256-258)GAT>CAT	p.D86H	XRN1_uc003eut.2_Missense_Mutation_p.D86H|XRN1_uc003euu.2_Missense_Mutation_p.D86H|XRN1_uc003euw.2_Missense_Mutation_p.D86H|XRN1_uc011bnh.1_5'UTR	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	86					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						GCCACACCATCTACAGCCATA	0.348													25	47					0	0	0	0	G	142151555	G	G	142151555	3	3	36	1	0	0	0	0	1	0	0	0	17527	913	32	2	5028	2	XRN1	3	142151555	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3972753	142151555	55870875	214	7014											
PAQR9	344838	broad.mit.edu	37	chr3	142681653	142681653	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagctgaggcctggcaacaGgtagtagtagtaggccaccg	11	6	14	10	1	0	1	0	1	0	0	0	1	0	1	3	4	2	6	3	4	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:142681653G>C	uc003evg.2	-	1	526	c.526C>G	c.(526-528)CTG>GTG	p.L176V	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	176	Helical; (Potential).					integral to membrane	receptor activity				0						CCTGGCAACAGGTAGTAGTAG	0.622													4	45					0	0	0	0	C	142681653	C	C	142681653	3	2	36	1	0	0	0	0	1	0	0	0	11496	991	35	4	611	4	PAQR9	3	142681653	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	530098	142681653	55340777	215	7015											
PLOD2	5352	broad.mit.edu	37	chr3	145804659	145804659	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatttcatgcttagctttatCaaaaaataccttgatgtcct	12	16	5	8	0	2	1	2	1	0	0	3	2	3	1	2	0	3	2	2	0	6	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:145804659C>T	uc003evs.1	-	10	1548	c.1042G>A	c.(1042-1044)GAT>AAT	p.D348N	PLOD2_uc003evq.1_5'Flank|PLOD2_uc011bnm.1_Missense_Mutation_p.D293N|PLOD2_uc003evr.1_Missense_Mutation_p.D348N	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	348					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	TTAGCTTTATCAAAAAATACC	0.284													13	28					0	0	0	0	T	145804659	T	T	145804659	3	4	36	1	0	0	0	0	1	0	0	0	12157	826	29	2	1278	2	PLOD2	3	145804659	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3123006	145804659	52217771	216	7016											
PLSCR2	57047	broad.mit.edu	37	chr3	146173093	146173093	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttccagagttatgacttctCgacccacattatcagtaatc	11	14	5	11	1	2	2	1	1	1	1	5	3	3	2	2	0	0	2	2	0	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:146173093C>T	uc003evv.1	-	5	587	c.254G>A	c.(253-255)CGA>CAA	p.R85Q	PLSCR2_uc003evw.1_Missense_Mutation_p.R154Q	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	85	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						TATGACTTCTCGACCCACATT	0.418													47	242					0	0	0	0	T	146173093	T	T	146173093	3	4	36	1	0	0	0	0	1	0	0	0	12165	884	31	1	436	1	PLSCR2	3	146173093	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	368434	146173093	51849337	217	7017											
IGSF10	285313	broad.mit.edu	37	chr3	151155740	151155740	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctccagaatcgagcagtttCactttgttgatggtcaaaga	11	13	9	8	1	3	3	2	1	1	2	5	4	3	3	1	1	1	3	1	1	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:151155740C>T	uc011bod.1	-	6	6609	c.6609G>A	c.(6607-6609)GTG>GTA	p.V2203V	IGSF10_uc011bob.1_Silent_p.V230V|IGSF10_uc011boc.1_Silent_p.V182V	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2203	Ig-like C2-type 8.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CGAGCAGTTTCACTTTGTTGA	0.418													128	215					0	0	0	0	T	151155740	T	T	151155740	2	4	36	1	0	0	0	0	0	0	0	1	7636	813	29	2		2	IGSF10	3	151155740	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4982647	151155740	46866690	218	7018											
SHOX2	6474	broad.mit.edu	37	chr3	157820574	157820574	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccagctcattgagttgttCcagggtgaaattggtccgac	8	12	11	10	1	1	2	1	2	0	0	4	3	4	2	3	2	1	3	3	2	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:157820574C>T	uc003fbr.2	-	2	587	c.448G>A	c.(448-450)GAA>AAA	p.E150K	SHOX2_uc003fbs.2_Missense_Mutation_p.E174K|SHOX2_uc010hvw.2_Missense_Mutation_p.E150K	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	150	Homeobox.				nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TTGAGTTGTTCCAGGGTGAAA	0.572													40	236					0	0	0	0	T	157820574	T	T	157820574	3	4	36	1	0	0	0	0	1	0	0	0	14354	864	30	2	563	2	SHOX2	3	157820574	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6664834	157820574	40201856	219	7019											
IFT80	57560	broad.mit.edu	37	chr3	160000298	160000298	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttgttcttccttcccaaatCgtttcacagaagtgatacag	10	15	6	10	1	2	2	1	1	1	1	5	2	4	2	2	0	1	2	2	0	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:160000298C>G	uc011boy.1	-	14	1917	c.1484G>C	c.(1483-1485)CGA>CCA	p.R495P	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Missense_Mutation_p.R358P|IFT80_uc003fdd.1_Missense_Mutation_p.R178P|IFT80_uc003fde.1_Missense_Mutation_p.R358P	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	495						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CTTCCCAAATCGTTTCACAGA	0.269													8	90					0	0	0	0	G	160000298	G	G	160000298	3	3	36	1	0	0	0	0	1	0	0	0	7603	884	31	3	877	3	IFT80	3	160000298	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2179724	160000298	38022132	220	7020											
ECT2	1894	broad.mit.edu	37	chr3	172486838	172486838	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agtcttctaaaagctccactCcagttccttcaaagcagtca	12	11	5	13	0	4	0	2	0	2	0	7	0	7	0	3	0	2	3	3	0	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:172486838C>G	uc003fii.2	+	12	1378	c.1240C>G	c.(1240-1242)CCA>GCA	p.P414A	ECT2_uc010hwv.1_Missense_Mutation_p.P445A|ECT2_uc003fih.2_Missense_Mutation_p.P413A|ECT2_uc003fij.1_Missense_Mutation_p.P414A|ECT2_uc003fik.1_Missense_Mutation_p.P414A|ECT2_uc003fil.1_Missense_Mutation_p.P445A	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	414					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AAGCTCCACTCCAGTTCCTTC	0.348													4	233					0	0	0	0	G	172486838	G	G	172486838	3	3	36	1	0	0	0	0	1	0	0	0	4923	855	30	2	1282	2	ECT2	3	172486838	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	12486540	172486838	25535592	221	7021											
NLGN1	22871	broad.mit.edu	37	chr3	173998755	173998755	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatgatgttcacaggagaTgcagccctcagcgcactact	11	8	10	12	1	2	2	2	1	0	1	2	4	2	2	1	1	4	3	1	1	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:173998755T>C	uc003fio.1	+	7	2557	c.2134T>C	c.(2134-2136)TGC>CGC	p.C712R	NLGN1_uc003fip.1_Missense_Mutation_p.C712R	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	729	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TCACAGGAGATGCAGCCCTCA	0.453													83	72					0	0	0	0	C	173998755	C	C	173998755	3	2	36	1	0	0	0	0	1	0	0	0	10515	1464	51	5	2152	5	NLGN1	3	173998755	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	1511917	173998755	24023675	222	7022											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			27	148					0	0	0	0	A	178936091	A	A	178936091	3	1	36	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4937336	178936091	19086339	223	7023											
GNB4	59345	broad.mit.edu	37	chr3	179123134	179123134	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcttgatctgcacgaaggtCaaagagccggcaagtggcat	11	8	12	10	2	3	2	1	1	2	1	3	3	3	2	1	3	2	3	1	3	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:179123134C>G	uc003fjv.3	-	9	1040	c.760G>C	c.(760-762)GAC>CAC	p.D254H	GNB4_uc003fju.3_Intron	NM_021629	NP_067642	Q9HAV0	GBB4_HUMAN	guanine nucleotide-binding protein, beta-4	254	WD 5.				cellular response to glucagon stimulus|energy reserve metabolic process	plasma membrane	signal transducer activity			skin(2)	2	all_cancers(143;2.01e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.237)			GCACGAAGGTCAAAGAGCCGG	0.418													47	106					0	0	0	0	G	179123134	G	G	179123134	3	3	36	1	0	0	0	0	1	0	0	0	6557	826	29	2	270	2	GNB4	3	179123134	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	187043	179123134	18899296	224	7024											
PEX5L	51555	broad.mit.edu	37	chr3	179533749	179533749	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttaagccttcttcaaatgctCcaggccagtccttgaagggg	9	11	10	11	0	2	1	1	1	1	0	4	1	4	1	4	3	2	1	4	3	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:179533749C>G	uc003fki.1	-	10	1113	c.983G>C	c.(982-984)GGA>GCA	p.G328A	PEX5L_uc011bqd.1_Missense_Mutation_p.G285A|PEX5L_uc011bqe.1_Missense_Mutation_p.G136A|PEX5L_uc011bqf.1_Missense_Mutation_p.G220A|PEX5L_uc003fkj.1_Missense_Mutation_p.G293A|PEX5L_uc010hxd.1_Missense_Mutation_p.G326A|PEX5L_uc011bqg.1_Missense_Mutation_p.G304A|PEX5L_uc011bqh.1_Missense_Mutation_p.G269A	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	328					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TTCAAATGCTCCAGGCCAGTC	0.473													24	213					0	0	0	0	G	179533749	G	G	179533749	3	3	36	1	0	0	0	0	1	0	0	0	11804	855	30	2	921	2	PEX5L	3	179533749	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	410615	179533749	18488681	225	7025											
PEX5L	51555	broad.mit.edu	37	chr3	179597738	179597738	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tagatctaaggatgaagtctCcgggactctgagaggctggc	10	9	14	8	1	3	3	0	2	3	2	4	6	3	5	1	4	0	1	1	4	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:179597738C>G	uc003fki.1	-	5	614	c.484G>C	c.(484-486)GAG>CAG	p.E162Q	PEX5L_uc011bqd.1_Missense_Mutation_p.E119Q|PEX5L_uc011bqe.1_5'UTR|PEX5L_uc011bqf.1_Intron|PEX5L_uc003fkj.1_Missense_Mutation_p.E127Q|PEX5L_uc010hxd.1_Missense_Mutation_p.E160Q|PEX5L_uc011bqg.1_Missense_Mutation_p.E138Q|PEX5L_uc011bqh.1_Missense_Mutation_p.E103Q	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	162					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			GATGAAGTCTCCGGGACTCTG	0.512													30	177					0	0	0	0	G	179597738	G	G	179597738	3	3	36	1	0	0	0	0	1	0	0	0	11804	864	30	2	1440	2	PEX5L	3	179597738	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	63989	179597738	18424692	226	7026											
HTR3D	200909	broad.mit.edu	37	chr3	183756393	183756393	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaataagggcccgggtctCacccccacccacctgcccgg	8	4	11	18	2	1	0	1	0	1	0	2	1	1	1	6	4	1	0	6	4	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:183756393C>T	uc011bqv.1	+	7	1116	c.1116C>T	c.(1114-1116)CTC>CTT	p.L372L	HTR3D_uc003fmj.2_Silent_p.L197L|HTR3D_uc011bqu.1_Silent_p.L322L|HTR3D_uc010hxp.2_Silent_p.L151L	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	372	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCCCGGGTCTCACCCCCACCC	0.453													5	77					0	0	0	0	T	183756393	T	T	183756393	2	4	36	1	0	0	0	0	0	0	0	1	7486	813	29	2		2	HTR3D	3	183756393	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4158655	183756393	14266037	227	7027											
HTR3C	170572	broad.mit.edu	37	chr3	183777329	183777329	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctacctgccagcagagagcGagaatcgtgccccattcaag	11	7	10	13	2	2	2	1	0	1	2	3	4	2	2	4	0	5	1	4	0	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:183777329G>A	uc003fmk.2	+	7	860	c.826G>A	c.(826-828)GAG>AAG	p.E276K		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine receptor 3 subunit C	276	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGCAGAGAGCGAGAATCGTGC	0.547													55	317					0	0	0	0	A	183777329	A	A	183777329	3	1	36	1	0	0	0	0	1	0	0	0	7485	1059	37	1	852	1	HTR3C	3	183777329	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	20936	183777329	14245101	228	7028											
HTR3C	170572	broad.mit.edu	37	chr3	183777427	183777427	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccagtggcacccccctcatCagtatggctcctcccacttt	6	10	7	18	0	2	0	2	0	0	0	4	0	4	0	6	2	0	3	6	2	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:183777427C>T	uc003fmk.2	+	7	958	c.924C>T	c.(922-924)ATC>ATT	p.I308I		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine receptor 3 subunit C	308	Helical; Name=3; (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CCCCCCTCATCAGTATGGCTC	0.587													47	353					0	0	0	0	T	183777427	T	T	183777427	2	4	36	1	0	0	0	0	0	0	0	1	7485	840	29	2		2	HTR3C	3	183777427	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	98	183777427	14245003	229	7029											
AP2M1	1173	broad.mit.edu	37	chr3	183896864	183896864	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tactttggcaagatcagcgaGgaaaacatcaagaacaattt	17	9	8	7	1	2	2	2	0	0	2	2	4	2	3	0	2	4	1	0	2	7	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:183896864G>C	uc011bqx.1	+	3	451	c.294G>C	c.(292-294)GAG>GAC	p.E98D	AP2M1_uc003fmw.2_Missense_Mutation_p.E98D|AP2M1_uc003fmx.2_Missense_Mutation_p.E98D|AP2M1_uc003fmy.2_Missense_Mutation_p.E98D|AP2M1_uc011bqy.1_5'Flank|AP2M1_uc011bqz.1_5'Flank	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	98					axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGATCAGCGAGGAAAACATCA	0.522													47	341					0	0	0	0	C	183896864	C	C	183896864	3	2	36	1	0	0	0	0	1	0	0	0	742	991	35	4	300	4	AP2M1	3	183896864	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	119437	183896864	14125566	230	7030											
PSMD2	5708	broad.mit.edu	37	chr3	184026289	184026289	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctggtggctgccatgcaGccccgaatgctggttacgtt	5	10	15	11	2	0	0	0	0	0	0	0	1	0	0	3	4	5	6	3	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:184026289G>A	uc003fnn.1	+	20	2511	c.2478G>A	c.(2476-2478)CAG>CAA	p.Q826Q	PSMD2_uc011brj.1_Silent_p.Q667Q|PSMD2_uc011brk.1_Silent_p.Q696Q	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	826					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	CTGCCATGCAGCCCCGAATGC	0.537											OREG0015948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	157	264					0	0	0	0	A	184026289	A	A	184026289	2	1	36	1	0	0	0	0	0	0	0	1	12760	962	34	4		4	PSMD2	3	184026289	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	129425	184026289	13996141	231	7031											
EIF4G1	1981	broad.mit.edu	37	chr3	184033995	184033995	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaaatgaacacgccttctCagccccgccaggtgaggggc	10	5	11	15	2	1	2	1	2	1	0	2	2	1	2	4	3	2	0	4	3	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:184033995C>T	uc003fnp.2	+	4	334	c.136C>T	c.(136-138)CAG>TAG	p.Q46*	EIF4G1_uc003fno.1_Nonsense_Mutation_p.Q46*|EIF4G1_uc010hxw.1_5'UTR|EIF4G1_uc003fnt.2_Intron|EIF4G1_uc003fnq.2_Intron|EIF4G1_uc003fnr.2_Intron|EIF4G1_uc010hxx.2_Nonsense_Mutation_p.Q46*|EIF4G1_uc003fns.2_Nonsense_Mutation_p.Q6*|EIF4G1_uc010hxy.2_Nonsense_Mutation_p.Q46*|EIF4G1_uc010hxz.1_Intron|EIF4G1_uc003fnv.3_Nonsense_Mutation_p.Q46*|EIF4G1_uc003fnu.3_Nonsense_Mutation_p.Q46*|EIF4G1_uc003fnw.2_Nonsense_Mutation_p.Q46*	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	46					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CACGCCTTCTCAGCCCCGCCA	0.617													12	114					0	0	0	0	T	184033995	T	T	184033995	4	4	36	1	0	0	0	0	0	1	0	0	5060	827	29	2	142	2	EIF4G1	3	184033995	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	7706	184033995	13988435	232	7032											
MAP3K13	9175	broad.mit.edu	37	chr3	185198141	185198141	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagtcctgatgagttagctGataaacttgaagaccgcttg	12	11	10	8	1	0	5	0	4	0	1	1	5	1	5	2	0	2	3	2	0	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:185198141G>A	uc010hyf.2	+	14	2889	c.2623G>A	c.(2623-2625)GAT>AAT	p.D875N	MAP3K13_uc011brt.1_Missense_Mutation_p.D668N|MAP3K13_uc011bru.1_Missense_Mutation_p.D731N|MAP3K13_uc003fpi.2_Missense_Mutation_p.D875N|MAP3K13_uc010hyg.2_Missense_Mutation_p.D565N	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	875					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TGAGTTAGCTGATAAACTTGA	0.483													82	211					0	0	0	0	A	185198141	A	A	185198141	3	1	36	1	0	0	0	0	1	0	0	0	9300	1290	45	2	2669	2	MAP3K13	3	185198141	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1164146	185198141	12824289	233	7033											
MAP3K13	9175	broad.mit.edu	37	chr3	185200197	185200197	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcagatggggagtgttctGatgccacagttaggaccaat	10	11	12	8	0	2	2	1	1	1	1	2	4	2	4	2	3	1	2	2	3	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:185200197G>C	uc010hyf.2	+	15	3120	c.2854G>C	c.(2854-2856)GAT>CAT	p.D952H	MAP3K13_uc011brt.1_Missense_Mutation_p.D745H|MAP3K13_uc011bru.1_Missense_Mutation_p.D808H|MAP3K13_uc003fpi.2_Missense_Mutation_p.D952H|MAP3K13_uc010hyg.2_Missense_Mutation_p.D642H	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	952					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GGAGTGTTCTGATGCCACAGT	0.413													6	582					0	0	0	0	C	185200197	C	C	185200197	3	2	36	1	0	0	0	0	1	0	0	0	9300	1290	45	2	2904	2	MAP3K13	3	185200197	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2056	185200197	12822233	234	7034											
ATP13A4	84239	broad.mit.edu	37	chr3	193220359	193220359	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtggtcaggagtgagacCaaatgcgctgtttaatgctg	10	10	15	6	1	1	1	1	1	0	1	1	3	1	2	1	3	2	3	1	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:193220359C>T	uc003ftd.2	-	3	412	c.304G>A	c.(304-306)GGT>AGT	p.G102S	ATP13A4_uc003fte.1_Missense_Mutation_p.G102S|ATP13A4_uc011bsr.1_5'UTR	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	102	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GGAGTGAGACCAAATGCGCTG	0.408													139	88					0	0	0	0	T	193220359	T	T	193220359	3	4	36	1	0	0	0	0	1	0	0	0	1128	594	21	4	3398	4	ATP13A4	3	193220359	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	8020162	193220359	4802071	235	7035											
ATP13A3	79572	broad.mit.edu	37	chr3	194140610	194140610	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgtgcttaagtcttacctGaagaacctggtcaacagagg	12	10	11	8	0	2	3	1	1	1	2	2	4	2	3	2	2	4	1	2	2	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:194140610G>A	uc003fty.3	-	30	3802	c.3400C>T	c.(3400-3402)CAG>TAG	p.Q1134*	ATP13A3_uc003ftx.3_Nonsense_Mutation_p.Q13*	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	1134					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AGTCTTACCTGAAGAACCTGG	0.318													43	168					0	0	0	0	A	194140610	A	A	194140610	4	1	36	1	0	0	0	0	0	1	0	0	1127	1299	45	2	292	2	ATP13A3	3	194140610	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	920251	194140610	3881820	236	7036											
SENP5	205564	broad.mit.edu	37	chr3	196656542	196656542	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacgacagtgactgtggagtCtttgtgctccaggtaaagaa	12	10	12	7	1	1	2	0	1	1	1	2	4	2	3	1	2	2	2	1	2	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:196656542C>G	uc003fwz.3	+	9	2394	c.2145C>G	c.(2143-2145)GTC>GTG	p.V715V	SENP5_uc011bty.1_Silent_p.V669V	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	715	Protease.				cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		ACTGTGGAGTCTTTGTGCTCC	0.393													42	116					0	0	0	0	G	196656542	G	G	196656542	2	3	36	1	0	0	0	0	0	0	0	1	14114	900	32	2		2	SENP5	3	196656542	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2515932	196656542	1365888	237	7037											
KIAA0226	9711	broad.mit.edu	37	chr3	197420604	197420604	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accttggatttcaaattcatCaacctcatcagcagagccag	13	10	6	12	0	5	1	5	0	0	1	5	2	5	2	3	1	3	1	3	1	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr3:197420604C>T	uc003fyc.2	-	11	1951	c.1768G>A	c.(1768-1770)GAT>AAT	p.D590N	KIAA0226_uc003fyd.3_Missense_Mutation_p.D545N|KIAA0226_uc003fye.1_Missense_Mutation_p.D297N|KIAA0226_uc003fyf.2_3'UTR	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	590	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		TCAAATTCATCAACCTCATCA	0.428													25	108					0	0	0	0	T	197420604	T	T	197420604	3	4	36	1	0	0	0	0	1	0	0	0	8201	826	29	2	1190	2	KIAA0226	3	197420604	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	764062	197420604	601826	238	7038											
PDE6B	5158	broad.mit.edu	37	chr4	651154	651154	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccagtccctgacacagttCctgggctggtcagtgatgaa	8	10	11	12	0	1	3	1	3	0	0	4	3	4	3	3	2	0	2	3	2	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:651154C>T	uc003gap.2	+	10	1325	c.1272C>T	c.(1270-1272)TTC>TTT	p.F424F	PDE6B_uc003gao.3_Silent_p.F424F|PDE6B_uc011buy.1_Silent_p.F145F|uc003gaq.1_5'Flank	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	424	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						TGACACAGTTCCTGGGCTGGT	0.622													16	26					0	0	0	0	T	651154	T	T	651154	2	4	36	1	0	0	0	0	0	0	0	1	11700	854	30	2		2	PDE6B	4	651154	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08		651154	190503122	239	7039											
DGKQ	1609	broad.mit.edu	37	chr4	955487	955487	+	Missense_Mutation	SNP	G	C	C																															cgcgagcacctggggatgttGatgaagatgaggccttcaat																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:955487G>C	uc003gbw.2	-	20	2525	c.2451C>G	c.(2449-2451)ATC>ATG	p.I817M	DGKQ_uc010ibn.2_Missense_Mutation_p.I804M	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	817					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TGGGGATGTTGATGAAGATGA	0.652													16	32					0	0	0	0	C	955487	C	C	955487	3	2	36	1	0	0	0	0	1	0	0	0	4495	1280	45	2	393	2	DGKQ	4	955487	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	304333	955487	190198789	240	7040	12	2									
DGKQ	1609	broad.mit.edu	37	chr4	955492	955492	+	Missense_Mutation	SNP	A	G	G																															gcacctggggatgttgatgaAgatgaggccttcaatactgg																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:955492A>G	uc003gbw.2	-	20	2520	c.2446T>C	c.(2446-2448)TTC>CTC	p.F816L	DGKQ_uc010ibn.2_Missense_Mutation_p.F803L	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	816					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ATGTTGATGAAGATGAGGCCT	0.662													16	34					0	0	0	0	G	955492	G	G	955492	3	3	36	1	0	0	0	0	1	0	0	0	4495	72	3	5	398	5	DGKQ	4	955492	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	5	955492	190198784	241	7041	12	2									
JAKMIP1	152789	broad.mit.edu	37	chr4	6114560	6114560	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcgggcttctcgcccttgctCcggcctttcttcgacatgct	2	14	9	16	4	2	0	0	0	2	0	6	1	3	0	3	2	2	3	3	2	0	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:6114560C>G	uc003giu.3	-	2	294	c.18G>C	c.(16-18)CGG>CGC	p.R6R	JAKMIP1_uc010idb.1_Silent_p.R6R|JAKMIP1_uc010idc.1_Silent_p.R6R|JAKMIP1_uc010idd.1_Silent_p.R6R|JAKMIP1_uc011bwc.1_Silent_p.R6R|JAKMIP1_uc003giv.3_Silent_p.R6R|JAKMIP1_uc010ide.2_Silent_p.R6R	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	6	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						CGCCCTTGCTCCGGCCTTTCT	0.632													24	44					0	0	0	0	G	6114560	G	G	6114560	2	3	36	1	0	0	0	0	0	0	0	1	7979	842	30	2		2	JAKMIP1	4	6114560	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5159068	6114560	185039716	242	7042											
DRD5	1816	broad.mit.edu	37	chr4	9784235	9784235	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggcgggctggacctgccAaacaacctggccaactggac	9	5	14	13	1	0	0	0	0	0	0	0	2	0	2	4	6	4	1	4	6	3	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:9784235A>G	uc003gmb.3	+	1	978	c.582A>G	c.(580-582)CCA>CCG	p.P194P		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	194	Extracellular (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TGGACCTGCCAAACAACCTGG	0.607													38	49					0	0	0	0	G	9784235	G	G	9784235	2	3	36	1	0	0	0	0	0	0	0	1	4782	117	5	5		5	DRD5	4	9784235	Silent	SNP	A	TCGA-CN-4723-01A-01D-1434-08	3669675	9784235	181370041	243	7043											
WDR19	57728	broad.mit.edu	37	chr4	39233560	39233560	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaatgttggcatagtgatgtCcttggaacaaataaaggtaa	16	11	10	4	0	0	1	0	1	0	0	1	2	1	2	1	3	1	3	1	3	7	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:39233560C>T	uc003gtv.2	+	18	2280	c.2126C>T	c.(2125-2127)TCC>TTC	p.S709F	WDR19_uc011byi.1_Missense_Mutation_p.S549F|WDR19_uc003gtw.1_Missense_Mutation_p.S306F	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	709					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						ATAGTGATGTCCTTGGAACAA	0.348													29	78					0	0	0	0	T	39233560	T	T	39233560	3	4	36	1	0	0	0	0	1	0	0	0	17347	855	30	2	2196	2	WDR19	4	39233560	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	29449325	39233560	151920716	244	7044											
LRRC66	339977	broad.mit.edu	37	chr4	52860790	52860790	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggccagggtgacaggccctCagatctatcagtgtcagagg	9	7	15	10	0	4	3	3	1	1	2	4	3	4	3	2	4	0	0	2	4	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:52860790C>T	uc003gzi.2	-	4	2411	c.2398G>A	c.(2398-2400)GAG>AAG	p.E800K		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	800						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GACAGGCCCTCAGATCTATCA	0.473													18	49					0	0	0	0	T	52860790	T	T	52860790	3	4	36	1	0	0	0	0	1	0	0	0	9068	835	29	2	248	2	LRRC66	4	52860790	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	13627230	52860790	138293486	245	7045											
RASL11B	65997	broad.mit.edu	37	chr4	53731941	53731941	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtttaagcaagccctctCtgccaaagtgaggactgtca	11	9	11	10	0	2	1	1	1	1	0	3	3	2	2	2	2	3	2	2	2	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:53731941C>A	uc003gzt.2	+	4	896	c.716C>A	c.(715-717)TCT>TAT	p.S239Y		NM_023940	NP_076429	Q9BPW5	RSLBB_HUMAN	RAS-like family 11 member B	239	Small GTPase-like.				small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0302)			CAAGCCCTCTCTGCCAAAGTG	0.567													21	62					4.26978e-12	4.46303e-12	1	0	A	53731941	A	A	53731941	3	1	36	1	0	0	0	0	1	0	0	0	13147	913	32	2	730	2	RASL11B	4	53731941	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	871151	53731941	137422335	246	7046											
PDGFRA	5156	broad.mit.edu	37	chr4	55136804	55136804	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcctttttttaaaaggtatCgaagcaaattaaagctgatc	15	14	6	6	1	0	1	0	1	0	0	3	2	1	1	1	1	2	3	1	1	7	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:55136804C>T	uc003han.3	+	8	1457	c.1126C>T	c.(1126-1128)CGA>TGA	p.R376*	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Nonsense_Mutation_p.R270*|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	376	Ig-like C2-type 4.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TAAAAGGTATCGAAGCAAATT	0.318			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			26	91					0	0	0	0	T	55136804	T	T	55136804	4	4	36	1	0	0	0	0	0	1	0	0	11715	876	31	1	1152	1	PDGFRA	4	55136804	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1404863	55136804	136017472	247	7047											
SRD5A3	79644	broad.mit.edu	37	chr4	56225583	56225583	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggtgccttactcaatctCtgttcctgggagcacctttt	5	17	8	11	0	2	0	1	0	1	0	4	1	3	1	3	2	3	2	3	2	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:56225583C>T	uc003hau.2	+	2	387	c.292C>T	c.(292-294)CTG>TTG	p.L98L		NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	98	Helical; (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			TACTCAATCTCTGTTCCTGGG	0.478													104	289					0	0	0	0	T	56225583	T	T	56225583	2	4	36	1	0	0	0	0	0	0	0	1	15206	912	32	2		2	SRD5A3	4	56225583	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1088779	56225583	134928693	248	7048											
CEP135	9662	broad.mit.edu	37	chr4	56847543	56847543	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctttaagagaaaaattaGaggtaagaagattgacatgt	19	10	10	2	0	0	5	0	1	0	4	0	6	0	5	0	1	1	2	0	1	7	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:56847543G>C	uc003hbi.2	+	13	2011	c.1777G>C	c.(1777-1779)GAG>CAG	p.E593Q	CEP135_uc003hbj.2_Missense_Mutation_p.E299Q	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	593	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					AGAAAAATTAGAGGTAAGAAG	0.284													50	164					0	0	0	0	C	56847543	C	C	56847543	3	2	36	1	0	0	0	0	1	0	0	0	3262	943	33	2	1823	2	CEP135	4	56847543	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	621960	56847543	134306733	249	7049											
UGT2B4	7363	broad.mit.edu	37	chr4	70361538	70361538	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagagctaaagtaacagctCagctgtatcagcagaagagc	15	6	10	10	0	2	3	2	0	0	3	2	3	2	3	1	0	6	6	1	0	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:70361538C>T	uc003hek.3	-	1	89	c.42G>A	c.(40-42)CTG>CTA	p.L14L	UGT2B4_uc011cap.1_Intron|UGT2B4_uc003hel.3_Silent_p.L14L	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	14					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						AGTAACAGCTCAGCTGTATCA	0.453													83	228					0	0	0	0	T	70361538	T	T	70361538	2	4	36	1	0	0	0	0	0	0	0	1	17029	813	29	2		2	UGT2B4	4	70361538	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	13513995	70361538	120792738	250	7050											
UGT2A1	10941	broad.mit.edu	37	chr4	70512724	70512724	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctgtaggtggtaggagatGaaatttcttattctgtcagt	9	16	11	5	0	3	2	1	1	2	1	4	3	4	2	1	3	0	2	1	3	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:70512724G>C	uc003hem.3	-	1	702	c.639C>G	c.(637-639)TTC>TTG	p.F213L	UGT2A1_uc011caq.1_Missense_Mutation_p.F213L|UGT2A1_uc010ihu.2_Missense_Mutation_p.F213L|UGT2A1_uc010iht.2_Missense_Mutation_p.F213L	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	213	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						GGTAGGAGATGAAATTTCTTA	0.368													35	124					0	0	0	0	C	70512724	C	C	70512724	3	2	36	1	0	0	0	0	1	0	0	0	17021	1281	45	2	968	2	UGT2A1	4	70512724	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	151186	70512724	120641552	251	7051											
GC	2638	broad.mit.edu	37	chr4	72634073	72634073	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cacagcaggcttcggtcaagGagacaacttccttcacaagt	12	8	9	12	1	2	1	2	0	0	1	4	2	3	1	1	3	2	2	1	3	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:72634073G>C	uc003hge.2	-	3	359	c.206C>G	c.(205-207)TCC>TGC	p.S69C	GC_uc003hgd.2_5'UTR|GC_uc010iie.2_Missense_Mutation_p.S69C|GC_uc010iif.2_Missense_Mutation_p.S88C	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	69	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TTCGGTCAAGGAGACAACTTC	0.522													15	41					0	0	0	0	C	72634073	C	C	72634073	3	2	36	1	0	0	0	0	1	0	0	0	6317	1174	41	2	1258	2	GC	4	72634073	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2121349	72634073	118520203	252	7052											
FRAS1	80144	broad.mit.edu	37	chr4	79321968	79321968	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcagatcaccaacagaatCttacaggccgaggctcctgg	11	7	10	13	1	2	2	1	0	1	2	3	3	3	2	3	3	3	2	3	3	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:79321968C>T	uc003hlb.2	+	30	4496	c.4056C>T	c.(4054-4056)ATC>ATT	p.I1352I	FRAS1_uc003hkw.2_Silent_p.I1352I	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1351	CSPG 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CCAACAGAATCTTACAGGCCG	0.458													18	47					0	0	0	0	T	79321968	T	T	79321968	2	4	36	1	0	0	0	0	0	0	0	1	6076	903	32	2		2	FRAS1	4	79321968	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6687895	79321968	111832308	253	7053											
FGF5	2250	broad.mit.edu	37	chr4	81188026	81188026	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttcagccacctgatcctCagcgcctgggctcacgggga	6	9	11	15	2	4	1	3	1	1	0	5	2	5	2	4	3	2	1	4	3	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:81188026C>T	uc003hmd.2	+	1	285	c.48C>T	c.(46-48)CTC>CTT	p.L16L	FGF5_uc003hme.2_Silent_p.L16L	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	16					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						ACCTGATCCTCAGCGCCTGGG	0.612													26	93					0	0	0	0	T	81188026	T	T	81188026	2	4	36	1	0	0	0	0	0	0	0	1	5887	813	29	2		2	FGF5	4	81188026	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1866058	81188026	109966250	254	7054											
HPSE	10855	broad.mit.edu	37	chr4	84234362	84234362	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccactgcaaatctgctgttCttaataacgcatttaggcca	11	13	6	11	1	2	0	0	0	2	0	3	0	3	0	2	1	3	4	2	1	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:84234362C>G	uc003hoj.3	-	4	677	c.578G>C	c.(577-579)AGA>ACA	p.R193T	HPSE_uc010ika.2_Intron|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Intron|HPSE_uc011cct.1_Missense_Mutation_p.R193T|HPSE_uc003hok.3_Missense_Mutation_p.R193T	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	193					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	ATCTGCTGTTCTTAATAACGC	0.423													32	58					0	0	0	0	G	84234362	G	G	84234362	3	3	36	1	0	0	0	0	1	0	0	0	7383	913	32	2	1089	2	HPSE	4	84234362	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3046336	84234362	106919914	255	7055											
WDFY3	23001	broad.mit.edu	37	chr4	85617224	85617224	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacttgaccctcataaaaaaGatgatggaagacatttacag	17	9	7	8	0	1	4	1	2	0	2	1	5	1	5	1	1	1	0	1	1	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:85617224G>C	uc003hpd.2	-	58	9208	c.8800C>G	c.(8800-8802)CTT>GTT	p.L2934V	WDFY3_uc003hpe.1_Missense_Mutation_p.L545V	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2934	BEACH.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCATAAAAAAGATGATGGAAG	0.413													49	139					0	0	0	0	C	85617224	C	C	85617224	3	2	36	1	0	0	0	0	1	0	0	0	17338	942	33	2	1824	2	WDFY3	4	85617224	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1382862	85617224	105537052	256	7056											
WDFY3	23001	broad.mit.edu	37	chr4	85617288	85617288	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttataaccgaagattaaGtcaatccactcatgtagatg	14	13	7	7	1	2	2	2	0	0	2	3	3	3	2	2	0	1	2	2	0	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:85617288G>C	uc003hpd.2	-	58	9144	c.8736C>G	c.(8734-8736)GAC>GAG	p.D2912E	WDFY3_uc003hpe.1_Missense_Mutation_p.D523E	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2912	BEACH.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CGAAGATTAAGTCAATCCACT	0.408													51	169					0	0	0	0	C	85617288	C	C	85617288	3	2	36	1	0	0	0	0	1	0	0	0	17338	1020	36	4	1888	4	WDFY3	4	85617288	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	64	85617288	105536988	257	7057											
ARHGAP24	83478	broad.mit.edu	37	chr4	86916572	86916572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttttttggggggaactttGaggaccctgttttggatggg	6	15	15	5	0	0	1	0	1	0	0	0	4	0	4	1	6	1	1	1	6	1	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:86916572G>A	uc003hpk.2	+	9	2214	c.1765G>A	c.(1765-1767)GAG>AAG	p.E589K	ARHGAP24_uc003hpl.2_Missense_Mutation_p.E494K|ARHGAP24_uc010ikf.2_Missense_Mutation_p.E504K|ARHGAP24_uc003hpm.2_Missense_Mutation_p.E496K	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	589					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		GGGGAACTTTGAGGACCCTGT	0.557													51	130					0	0	0	0	A	86916572	A	A	86916572	3	1	36	1	0	0	0	0	1	0	0	0	873	1291	45	2	1911	2	ARHGAP24	4	86916572	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1299284	86916572	104237704	258	7058											
HERC5	51191	broad.mit.edu	37	chr4	89421102	89421102	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcaaacacttctggatgatGaaggtgataactttgaggaa	14	11	11	5	0	1	4	0	4	1	0	1	6	1	6	0	3	3	1	0	3	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:89421102G>C	uc003hrt.2	+	19	2623	c.2470G>C	c.(2470-2472)GAA>CAA	p.E824Q	HERC5_uc011cdm.1_Missense_Mutation_p.E462Q	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	824	HECT.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		TCTGGATGATGAAGGTGATAA	0.289													29	103					0	0	0	0	C	89421102	C	C	89421102	3	2	36	1	0	0	0	0	1	0	0	0	7100	1291	45	2	2544	2	HERC5	4	89421102	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2504530	89421102	101733174	259	7059											
NAP1L5	266812	broad.mit.edu	37	chr4	89618627	89618627	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatcaaatttggcttctatCttatcgcatcgcttctgcag	8	17	6	10	2	4	0	1	0	3	0	6	0	4	0	0	1	1	4	0	1	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:89618627C>G	uc003hrx.2	-	1	397	c.279G>C	c.(277-279)AAG>AAC	p.K93N	HERC3_uc003hrw.1_Intron|HERC3_uc011cdn.1_Intron|HERC3_uc011cdo.1_Intron	NM_153757	NP_715638	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	93	Potential.				nucleosome assembly	nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		TGGCTTCTATCTTATCGCATC	0.458													68	138					0	0	0	0	G	89618627	G	G	89618627	3	3	36	1	0	0	0	0	1	0	0	0	10213	912	32	2	273	2	NAP1L5	4	89618627	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	197525	89618627	101535649	260	7060											
ADH5	128	broad.mit.edu	37	chr4	100006310	100006310	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgggggtgccacctctatctCctctatggagagaggctttc	6	12	12	11	0	3	1	0	0	3	1	5	3	3	2	3	4	1	1	3	4	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:100006310C>T	uc003hui.2	-	2	150	c.70G>A	c.(70-72)GAG>AAG	p.E24K	ADH5_uc003huk.1_Missense_Mutation_p.E24K|ADH5_uc003huj.2_5'UTR	NM_000671	NP_000662	P11766	ADHX_HUMAN	class III alcohol dehydrogenase, chi subunit	24					ethanol oxidation|response to redox state		alcohol dehydrogenase (NAD) activity|electron carrier activity|fatty acid binding|formaldehyde dehydrogenase activity|S-(hydroxymethyl)glutathione dehydrogenase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.5e-07)	NADH(DB00157)	ACCTCTATCTCCTCTATGGAG	0.453													10	6					0	0	0	0	T	100006310	T	T	100006310	3	4	36	1	0	0	0	0	1	0	0	0	311	864	30	2	1086	2	ADH5	4	100006310	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	10387683	100006310	91147966	261	7061											
CENPE	1062	broad.mit.edu	37	chr4	104054926	104054926	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtacatcacaatcttgttGaaggtgctgtattttaatta	11	17	8	5	0	2	1	1	1	1	0	2	1	2	1	0	2	2	4	0	2	6	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:104054926G>A	uc003hxb.1	-	41	6736	c.6646C>T	c.(6646-6648)CAA>TAA	p.Q2216*	CENPE_uc003hxc.1_Nonsense_Mutation_p.Q2095*	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	2216	Kinetochore-binding domain.|Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CAATCTTGTTGAAGGTGCTGT	0.289													13	32					0	0	0	0	A	104054926	A	A	104054926	4	1	36	1	0	0	0	0	0	1	0	0	3245	1299	45	2	1495	2	CENPE	4	104054926	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4048616	104054926	87099350	262	7062											
ANK2	287	broad.mit.edu	37	chr4	114280341	114280341	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaaaatctgccacctgttGagaccgagcactcagttcct	10	11	8	12	1	2	2	1	2	1	1	3	4	3	2	4	0	2	3	4	0	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:114280341G>C	uc003ibe.3	+	38	10667	c.10567G>C	c.(10567-10569)GAG>CAG	p.E3523Q	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.E825Q|ANK2_uc011cgb.1_Missense_Mutation_p.E3538Q	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3490					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GCCACCTGTTGAGACCGAGCA	0.468													56	152					0	0	0	0	C	114280341	C	C	114280341	3	2	36	1	0	0	0	0	1	0	0	0	621	1291	45	2	10782	2	ANK2	4	114280341	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	10225415	114280341	76873935	263	7063											
PRSS12	8492	broad.mit.edu	37	chr4	119256647	119256647	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatgggaaaagctacacgtGacagcagctgccatcttctg	11	8	10	12	1	2	1	0	1	2	0	2	2	2	2	2	1	5	3	2	1	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:119256647G>C	uc003ica.1	-	3	848	c.801C>G	c.(799-801)GTC>GTG	p.V267V		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	267	SRCR 1.					membrane	scavenger receptor activity			skin(1)	1						AGCTACACGTGACAGCAGCTG	0.403													32	134					0	0	0	0	C	119256647	C	C	119256647	2	2	36	1	0	0	0	0	0	0	0	1	12677	1277	45	2		2	PRSS12	4	119256647	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4976306	119256647	71897629	264	7064											
PDE5A	8654	broad.mit.edu	37	chr4	120419875	120419875	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagcaaagggaaacagtcctCtgacacgtgggtcagggcct	11	7	13	10	1	2	1	1	1	1	0	3	2	3	2	2	3	2	1	2	3	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:120419875C>G	uc003idh.2	-	21	2664	c.2509G>C	c.(2509-2511)GAG>CAG	p.E837Q	uc003ide.3_Intron|PDE5A_uc003idf.2_Missense_Mutation_p.E795Q|PDE5A_uc003idg.2_Missense_Mutation_p.E785Q	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	837	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	AAACAGTCCTCTGACACGTGG	0.502													50	138					0	0	0	0	G	120419875	G	G	120419875	3	3	36	1	0	0	0	0	1	0	0	0	11698	922	32	2	122	2	PDE5A	4	120419875	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1163228	120419875	70734401	265	7065											
KIAA1109	84162	broad.mit.edu	37	chr4	123167863	123167863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttatgtttgttacaagcctCagtggaagaatctccaacta	12	13	7	9	0	2	1	1	0	1	1	3	2	2	2	2	1	3	2	2	1	7	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:123167863C>T	uc003ieh.2	+	32	5255	c.5210C>T	c.(5209-5211)TCA>TTA	p.S1737L	KIAA1109_uc003iek.2_Missense_Mutation_p.S356L	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1737					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTACAAGCCTCAGTGGAAGAA	0.378													30	124					0	0	0	0	T	123167863	T	T	123167863	3	4	36	1	0	0	0	0	1	0	0	0	8247	838	29	2	5336	2	KIAA1109	4	123167863	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2747988	123167863	67986413	266	7066											
KIAA1109	84162	broad.mit.edu	37	chr4	123245661	123245661	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcatttctgcttctggaaGaccacctcttaagcgaatgg	11	11	9	10	1	3	1	0	0	3	1	3	3	3	2	2	2	3	2	2	2	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:123245661G>A	uc003ieh.2	+	62	10919	c.10874G>A	c.(10873-10875)AGA>AAA	p.R3625K	KIAA1109_uc003iel.1_Missense_Mutation_p.R1560K|KIAA1109_uc003iem.2_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3625					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GCTTCTGGAAGACCACCTCTT	0.378													18	78					0	0	0	0	A	123245661	A	A	123245661	3	1	36	1	0	0	0	0	1	0	0	0	8247	942	33	2	11120	2	KIAA1109	4	123245661	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	77798	123245661	67908615	267	7067											
FAT4	79633	broad.mit.edu	37	chr4	126329825	126329825	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actaccatcagagtttatttCaatattctagatgtaaatga	15	15	5	6	0	3	3	2	1	1	2	3	3	3	3	1	0	1	2	1	0	7	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:126329825C>T	uc003ifj.3	+	4	5796	c.5796C>T	c.(5794-5796)TTC>TTT	p.F1932F	FAT4_uc011cgp.1_Silent_p.F230F	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1932	Cadherin 18.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GAGTTTATTTCAATATTCTAG	0.348													50	149					0	0	0	0	T	126329825	T	T	126329825	2	4	36	1	0	0	0	0	0	0	0	1	5724	825	29	2		2	FAT4	4	126329825	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3084164	126329825	64824451	268	7068											
FAT4	79633	broad.mit.edu	37	chr4	126411784	126411784	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgatattcctcacaactcaGaaaccatccccagcgcccct	11	8	4	18	1	2	2	2	1	0	1	4	2	4	2	6	0	3	0	6	0	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:126411784G>C	uc003ifj.3	+	17	13807	c.13807G>C	c.(13807-13809)GAA>CAA	p.E4603Q	FAT4_uc011cgp.1_Missense_Mutation_p.E2844Q|FAT4_uc003ifi.1_Missense_Mutation_p.E2080Q	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4603	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCACAACTCAGAAACCATCCC	0.493													23	74					0	0	0	0	C	126411784	C	C	126411784	3	2	36	1	0	0	0	0	1	0	0	0	5724	943	33	2	13873	2	FAT4	4	126411784	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	81959	126411784	64742492	269	7069											
INTU	27152	broad.mit.edu	37	chr4	128626859	128626859	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagaattggtcagttgatCatatggagagaagtgtttcc	13	12	11	5	0	2	3	2	1	0	2	3	5	3	4	1	2	0	2	1	2	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:128626859C>G	uc003ifk.1	+	11	1750	c.1680C>G	c.(1678-1680)ATC>ATG	p.I560M	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	560										ovary(1)	1						GTCAGTTGATCATATGGAGAG	0.443													29	319					0	0	0	0	G	128626859	G	G	128626859	3	3	36	1	0	0	0	0	1	0	0	0	7825	816	29	2	1722	2	INTU	4	128626859	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2215075	128626859	62527417	270	7070											
MFSD8	256471	broad.mit.edu	37	chr4	128863250	128863250	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acatgcttatgtttgccatgGaacttgttctttcctgaagg	8	16	9	8	0	1	1	0	1	1	0	2	2	2	2	2	2	3	3	2	2	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:128863250G>C	uc003ifp.2	-	6	666	c.503C>G	c.(502-504)TCC>TGC	p.S168C	MFSD8_uc011cgu.1_Missense_Mutation_p.S123C|MFSD8_uc011cgv.1_Intron|MFSD8_uc011cgw.1_Intron|MFSD8_uc011cgx.1_Missense_Mutation_p.S123C	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	168	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						GTTTGCCATGGAACTTGTTCT	0.353													35	189					0	0	0	0	C	128863250	C	C	128863250	3	2	36	1	0	0	0	0	1	0	0	0	9591	1174	41	2	1085	2	MFSD8	4	128863250	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	236391	128863250	62291026	271	7071											
TTC29	83894	broad.mit.edu	37	chr4	147741384	147741384	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcaagtatttaattgcttCtgtcatctctccttggctag	7	19	6	9	0	4	0	2	0	2	0	6	0	5	0	1	1	1	3	1	1	4	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:147741384C>G	uc003ikw.3	-	10	1221	c.994G>C	c.(994-996)GAA>CAA	p.E332Q	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Missense_Mutation_p.E358Q|TTC29_uc010ipd.1_Missense_Mutation_p.E332Q	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	332	TPR 4.						binding				0	all_hematologic(180;0.151)					TTAATTGCTTCTGTCATCTCT	0.353													8	55					0	0	0	0	G	147741384	G	G	147741384	3	3	36	1	0	0	0	0	1	0	0	0	16764	922	32	2	449	2	TTC29	4	147741384	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	18878134	147741384	43412892	272	7072											
ARHGAP10	79658	broad.mit.edu	37	chr4	148944413	148944413	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctttatgctttgttggaaGatttttcggacgccgcccga	6	15	10	10	4	0	1	0	0	0	1	2	4	1	3	3	2	1	2	3	2	2	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:148944413G>C	uc003ilf.2	+	19	1717	c.1717_splice	c.e19-1	p.I573_splice	ARHGAP10_uc003ilg.2_Splice_Site_p.I222_splice|ARHGAP10_uc003ilh.2_Splice_Site_p.I154_splice|ARHGAP10_uc003ili.2_Missense_Mutation_p.K5N	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10						apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		TTTGTTGGAAGATTTTTCGGA	0.483													3	102					0	0	0	0	C	148944413	C	C	148944413	5	2	36	1	0	0	0	0	0	0	1	0	862	956	33	2	1790	2	ARHGAP10	4	148944413	Splice_Site	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1203029	148944413	42209863	273	7073											
LRBA	987	broad.mit.edu	37	chr4	151186875	151186875	+	Nonstop_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgtacagctgtcaccatCagtagcgggtttggtattca	9	13	11	8	1	3	1	3	1	0	0	3	1	3	1	1	2	3	5	1	2	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:151186875C>A	uc010ipj.2	-	58	9065	c.8591G>T	c.(8590-8592)TGA>TTA	p.*2864L	LRBA_uc010ipi.2_Nonstop_Mutation_p.*386L|LRBA_uc003ils.3_Nonstop_Mutation_p.*759L|LRBA_uc003ilt.3_Nonstop_Mutation_p.*1512L|LRBA_uc003ilu.3_Nonstop_Mutation_p.*2852L|LRBA_uc003ilr.3_Nonstop_Mutation_p.*284L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2864						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CTGTCACCATCAGTAGCGGGT	0.448													13	25					4.3838e-07	4.52045e-07	1	0	A	151186875	A	A	151186875	4	1	36	1	0	0	0	0	0	0	0	0	8981	837	29	2	4	2	LRBA	4	151186875	Nonstop_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2242462	151186875	39967401	274	7074											
LRBA	987	broad.mit.edu	37	chr4	151509251	151509251	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttcatccacctcaaaataGagttcggaggaggtgacaga	13	9	10	9	1	3	3	2	1	1	2	5	5	4	5	2	3	0	1	2	3	3	3	rs4613549		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:151509251G>C	uc010ipj.2	-	41	6786	c.6312C>G	c.(6310-6312)CTC>CTG	p.L2104L	LRBA_uc003ilt.3_Silent_p.L752L|LRBA_uc003ilu.3_Silent_p.L2093L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2104						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CCTCAAAATAGAGTTCGGAGG	0.473													5	289					0	0	0	0	C	151509251	C	C	151509251	2	2	36	1	0	0	0	0	0	0	0	1	8981	929	33	2		2	LRBA	4	151509251	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	322376	151509251	39645025	275	7075											
DCHS2	54798	broad.mit.edu	37	chr4	155155862	155155862	+	Frame_Shift_Del	DEL	G	-	-																															ggcagagaaccaagatggtaGgggatgggagagcgtgggtg																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:155155862delG	uc003inw.2	-	25	8577	c.8577delC	c.(8575-8577)CCCfs	p.P2859fs		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2859					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CAAGATGGTAGGGGATGGGAG	0.542													---	---	---								-	155155862	-	-	155155862	7	5	36	1	0	1	0	1	0	0	0	0	4305	987	35	0	177	0	DCHS2	4	155155862	Frame_Shift_Del	DEL	G	TCGA-CN-4723-01A-01D-1434-08	3646611	155155862	35998414	276	7076											
RXFP1	59350	broad.mit.edu	37	chr4	159568311	159568311	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcttcattcagaagatacaGaaagtattggagcccagatt	14	11	8	8	0	3	4	2	0	1	4	3	5	3	5	1	1	2	1	1	1	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:159568311G>A	uc003ipz.2	+	16	1796	c.1714G>A	c.(1714-1716)GAA>AAA	p.E572K	RXFP1_uc011cja.1_Missense_Mutation_p.E467K|RXFP1_uc010iqo.2_Missense_Mutation_p.E524K|RXFP1_uc011cjb.1_Missense_Mutation_p.E470K|RXFP1_uc010iqk.2_Missense_Mutation_p.E440K|RXFP1_uc011cjc.1_Missense_Mutation_p.E491K|RXFP1_uc011cjd.1_Missense_Mutation_p.E491K|RXFP1_uc010iql.2_Missense_Mutation_p.E416K|RXFP1_uc011cje.1_Missense_Mutation_p.E599K|RXFP1_uc010iqm.2_Missense_Mutation_p.E539K|RXFP1_uc011cjf.1_Missense_Mutation_p.E441K|RXFP1_uc010iqn.2_Missense_Mutation_p.E517K	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	572	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		AGAAGATACAGAAAGTATTGG	0.333													30	89					0	0	0	0	A	159568311	A	A	159568311	3	1	36	1	0	0	0	0	1	0	0	0	13824	943	33	2	1776	2	RXFP1	4	159568311	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4412449	159568311	31585965	277	7077											
HAND2	9464	broad.mit.edu	37	chr4	174449901	174449901	+	Silent	SNP	C	T	T																															ctgaccagctccttcttcctCttctcctctttcacgtcggt																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:174449901C>T	uc003ith.1	-	1	1478	c.540G>A	c.(538-540)AAG>AAA	p.K180K	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Missense_Mutation_p.E146K|HAND2_uc010ire.1_Silent_p.K180K	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	180					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CCTTCTTCCTCTTCTCCTCTT	0.602													6	28					0	0	0	0	T	174449901	T	T	174449901	2	4	36	1	0	0	0	0	0	0	0	1	6989	912	32	2		2	HAND2	4	174449901	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	14881590	174449901	16704375	278	7078	13	2									
HAND2	9464	broad.mit.edu	37	chr4	174449906	174449906	+	Nonsense_Mutation	SNP	C	A	A																															cagctccttcttcctcttctCctctttcacgtcggtcttct																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr4:174449906C>A	uc003ith.1	-	1	1473	c.535G>T	c.(535-537)GAG>TAG	p.E179*	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Missense_Mutation_p.G144V|HAND2_uc010ire.1_Nonsense_Mutation_p.E179*	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	179					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TTCCTCTTCTCCTCTTTCACG	0.612													6	27					0.00116845	0.00118983	1	0	A	174449906	A	A	174449906	4	1	36	1	0	0	0	0	0	1	0	0	6989	864	30	2	126	2	HAND2	4	174449906	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5	174449906	16704370	279	7079	13	2									
SLC6A18	348932	broad.mit.edu	37	chr5	1239639	1239639	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctctctgtccctggccttCggaggacacatcgcttttgc	4	14	9	14	2	2	0	0	0	2	0	6	2	3	2	2	3	1	1	2	3	0	4	rs137936927	byFrequency	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:1239639C>T	uc003jby.1	+	6	930	c.807C>T	c.(805-807)TTC>TTT	p.F269F		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	269	Helical; Name=6; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CCCTGGCCTTCGGAGGACACA	0.592													6	259					0	0	0	0	T	1239639	T	T	1239639	2	4	36	1	0	0	0	0	0	0	0	1	14745	883	31	1		1	SLC6A18	5	1239639	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08		1239639	179675621	280	7080											
KIAA0947	23379	broad.mit.edu	37	chr5	5461061	5461061	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcttctccccttggcaaaagGccattaaatgaactcatgga	12	11	7	11	0	3	1	1	1	2	0	4	2	3	2	3	3	1	1	3	3	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:5461061G>A	uc003jdm.3	+	13	1836	c.1614G>A	c.(1612-1614)AGG>AGA	p.R538R		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	538										ovary(1)|central_nervous_system(1)	2						TTGGCAAAAGGCCATTAAATG	0.448													74	267					0	0	0	0	A	5461061	A	A	5461061	2	1	36	1	0	0	0	0	0	0	0	1	8241	1194	42	4		4	KIAA0947	5	5461061	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4221422	5461061	175454199	281	7081											
NSUN2	54888	broad.mit.edu	37	chr5	6632078	6632078	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctttaagcaatggagaatCtcttttgcgtggctattgaa	10	16	9	6	1	2	2	0	1	2	1	3	3	2	2	0	2	2	2	0	2	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:6632078C>G	uc003jdu.2	-	3	332	c.267G>C	c.(265-267)GAG>GAC	p.E89D	NSUN2_uc011cmk.1_Intron|NSUN2_uc003jdv.2_5'UTR|SRD5A1_uc003jdw.2_5'Flank|SRD5A1_uc011cml.1_5'Flank|SRD5A1_uc011cmm.1_5'Flank	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	89						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						AATGGAGAATCTCTTTTGCGT	0.353													58	244					0	0	0	0	G	6632078	G	G	6632078	3	3	36	1	0	0	0	0	1	0	0	0	10732	912	32	2	2104	2	NSUN2	5	6632078	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1171017	6632078	174283182	282	7082											
SEMA5A	9037	broad.mit.edu	37	chr5	9044561	9044561	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtattaaggggggcaggtGagacggggtggatgacagtc	9	8	20	4	1	0	2	0	2	0	1	1	4	0	3	0	8	0	2	0	8	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:9044561G>T	uc003jek.2	-	22	3741	c.3029C>A	c.(3028-3030)TCA>TAA	p.S1010*		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	1010	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GGGGGCAGGTGAGACGGGGTG	0.527													68	228					4.60868e-44	4.99648e-44	1	0	T	9044561	T	T	9044561	4	4	36	1	0	0	0	0	0	1	0	0	14102	1294	45	2	203	2	SEMA5A	5	9044561	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2412483	9044561	171870699	283	7083											
PDZD2	23037	broad.mit.edu	37	chr5	32037440	32037440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaatcaagctcaagagtcGcctttcaggtaggtgggggc	11	9	13	8	1	3	1	3	0	0	1	4	1	3	1	1	4	1	2	1	4	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:32037440G>A	uc003jhl.2	+	7	1899	c.1511G>A	c.(1510-1512)CGC>CAC	p.R504H	PDZD2_uc003jhm.2_Missense_Mutation_p.R504H|PDZD2_uc011cnx.1_Missense_Mutation_p.R330H	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	504					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CTCAAGAGTCGCCTTTCAGGT	0.547													9	39					0	0	0	0	A	32037440	A	A	32037440	3	1	36	1	0	0	0	0	1	0	0	0	11755	1087	38	1	1533	1	PDZD2	5	32037440	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	22992879	32037440	148877820	284	7084											
C5orf23	79614	broad.mit.edu	37	chr5	32789775	32789775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcaaggcacatgtgccttCtttgccccaaatgcatcact	10	11	6	14	0	3	0	2	0	1	0	3	0	3	0	3	1	3	2	3	1	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:32789775C>T	uc003jhw.1	+	1	831	c.268C>T	c.(268-270)CTT>TTT	p.L90F		NM_024563	NP_078839			hypothetical protein LOC79614												0						CATGTGCCTTCTTTGCCCCAA	0.403													51	195					0	0	0	0	T	32789775	T	T	32789775	3	4	36	1	0	0	0	0	1	0	0	0	2296	913	32	2	270	2	C5orf23	5	32789775	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	752335	32789775	148125485	285	7085											
AGXT2	64902	broad.mit.edu	37	chr5	35010167	35010167	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggacgtctccaacaatttCaaattcatcccgcagcttag	11	11	6	13	3	3	0	2	0	1	0	6	1	4	1	2	1	2	2	2	1	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:35010167C>A	uc003jjf.2	-	12	1355	c.1276G>T	c.(1276-1278)GAA>TAA	p.E426*	AGXT2_uc003jje.1_Nonsense_Mutation_p.E79*|AGXT2_uc011com.1_Nonsense_Mutation_p.E351*	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	426					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	CCAACAATTTCAAATTCATCC	0.428													43	184					8.20599e-20	8.73402e-20	1	0	A	35010167	A	A	35010167	4	1	36	1	0	0	0	0	0	1	0	0	405	835	29	2	280	2	AGXT2	5	35010167	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2220392	35010167	145905093	286	7086											
CAPSL	133690	broad.mit.edu	37	chr5	35910094	35910094	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatacttcacgaaggtcttcGattgttataacaccatctcc	11	14	5	11	2	3	0	1	0	2	0	5	2	3	0	2	1	2	1	2	1	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:35910094G>A	uc003jjt.1	-	4	494	c.399C>T	c.(397-399)ATC>ATT	p.I133I	CAPSL_uc003jju.1_Silent_p.I133I	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	133	EF-hand 3.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			GAAGGTCTTCGATTGTTATAA	0.383													62	211					0	0	0	0	A	35910094	A	A	35910094	2	1	36	1	0	0	0	0	0	0	0	1	2651	1048	37	1		1	CAPSL	5	35910094	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	899927	35910094	145005166	287	7087											
NUP155	9631	broad.mit.edu	37	chr5	37302930	37302930	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcaccatcggcagctattGatgaaatggcagtggaactt	12	11	10	8	1	1	2	1	2	0	0	2	3	1	3	1	3	2	3	1	3	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:37302930G>C	uc003jku.1	-	29	3516	c.3398C>G	c.(3397-3399)TCA>TGA	p.S1133*	NUP155_uc003jkt.1_Nonsense_Mutation_p.S1074*|NUP155_uc010iuz.1_Nonsense_Mutation_p.S1069*	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	1133					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGCAGCTATTGATGAAATGGC	0.408													51	212					0	0	0	0	C	37302930	C	C	37302930	4	2	36	1	0	0	0	0	0	1	0	0	10810	1294	45	2	805	2	NUP155	5	37302930	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1392836	37302930	143612330	288	7088											
C9	735	broad.mit.edu	37	chr5	39364534	39364534	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcttatttctaaaatgcaGattgcaactgcaaagctccg	13	12	7	9	1	1	1	0	0	1	1	2	1	2	1	1	0	6	5	1	0	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:39364534G>C	uc003jlv.3	-	1	122	c.33C>G	c.(31-33)ATC>ATG	p.I11M		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	11					complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CTAAAATGCAGATTGCAACTG	0.502													26	116					0	0	0	0	C	39364534	C	C	39364534	3	2	36	1	0	0	0	0	1	0	0	0	2455	932	33	2	1690	2	C9	5	39364534	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2061604	39364534	141550726	289	7089											
NNT	23530	broad.mit.edu	37	chr5	43659377	43659377	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgcagagggcttcctgctCaacaacaatctgctgaccat	10	10	9	12	0	2	2	1	1	1	1	3	2	3	2	2	1	5	4	2	1	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:43659377C>T	uc003joe.2	+	17	2814	c.2559C>T	c.(2557-2559)CTC>CTT	p.L853L	NNT_uc003jof.2_Silent_p.L853L	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	853	Helical; (Potential).				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	GCTTCCTGCTCAACAACAATC	0.512													34	113					0	0	0	0	T	43659377	T	T	43659377	2	4	36	1	0	0	0	0	0	0	0	1	10564	813	29	2		2	NNT	5	43659377	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4294843	43659377	137255883	290	7090											
HCN1	348980	broad.mit.edu	37	chr5	45262789	45262789	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggataattgatgggagcgAttgcctgcaccatctccctg	9	10	12	10	1	1	1	0	1	1	0	2	5	1	3	3	2	3	1	3	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:45262789A>T	uc003jok.2	-	8	1932	c.1907T>A	c.(1906-1908)ATC>AAC	p.I636N		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	636	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GATGGGAGCGATTGCCTGCAC	0.478													41	139					0	0	0	0	T	45262789	T	T	45262789	3	4	36	1	0	0	0	0	1	0	0	0	7035	333	12	5	769	5	HCN1	5	45262789	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	1603412	45262789	135652471	291	7091											
HCN1	348980	broad.mit.edu	37	chr5	45396681	45396681	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atggcatagcaggtggccccGacgatcatgctcagcatggt	9	8	13	11	2	2	0	2	0	0	0	2	2	2	0	2	4	3	4	2	4	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:45396681G>C	uc003jok.2	-	4	1168	c.1143C>G	c.(1141-1143)GTC>GTG	p.V381V		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	381	Helical; Name=Segment S6; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AGGTGGCCCCGACGATCATGC	0.507													24	60					0	0	0	0	C	45396681	C	C	45396681	2	2	36	1	0	0	0	0	0	0	0	1	7035	1045	37	3		3	HCN1	5	45396681	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	133892	45396681	135518579	292	7092											
PARP8	79668	broad.mit.edu	37	chr5	50073932	50073932	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccattgatgatgtagataTtgatctgcatatcgatgtta	12	15	9	5	1	1	4	0	3	1	1	2	5	1	4	1	0	2	3	1	0	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:50073932T>G	uc003jon.3	+	9	730	c.548T>G	c.(547-549)ATT>AGT	p.I183S	PARP8_uc011cpz.1_Missense_Mutation_p.I75S|PARP8_uc003joo.2_Missense_Mutation_p.I183S|PARP8_uc003jop.2_Missense_Mutation_p.I183S	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	183						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GATGTAGATATTGATCTGCAT	0.279													18	51					0	0	0	0	G	50073932	G	G	50073932	3	3	36	1	0	0	0	0	1	0	0	0	11519	1493	52	5	578	5	PARP8	5	50073932	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	4677251	50073932	130841328	293	7093											
ITGA2	3673	broad.mit.edu	37	chr5	52367846	52367846	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggcactagccctgcccttGaagcctattctgagactgcc	7	10	9	15	0	1	2	0	2	1	1	1	3	1	2	4	1	4	1	4	1	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:52367846G>A	uc003joy.2	+	18	2457	c.2314G>A	c.(2314-2316)GAA>AAA	p.E772K	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.E696K|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	772	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CCCTGCCCTTGAAGCCTATTC	0.468													18	49					0	0	0	0	A	52367846	A	A	52367846	3	1	36	1	0	0	0	0	1	0	0	0	7914	1291	45	2	2384	2	ITGA2	5	52367846	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2293914	52367846	128547414	294	7094											
DHX29	54505	broad.mit.edu	37	chr5	54569133	54569133	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattttaccttcctgactccTggagggggaagtgtgaatgc	9	12	12	8	0	0	2	0	2	0	0	2	4	2	4	3	3	2	0	3	3	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:54569133T>A	uc003jpx.2	-	17	2883	c.2763A>T	c.(2761-2763)CCA>CCT	p.P921P	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	921	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TCCTGACTCCTGGAGGGGGAA	0.363													27	70					0	0	0	0	A	54569133	A	A	54569133	2	1	36	1	0	0	0	0	0	0	0	1	4525	1567	55	5		5	DHX29	5	54569133	Silent	SNP	T	TCGA-CN-4723-01A-01D-1434-08	2201287	54569133	126346127	295	7095											
IPO11	51194	broad.mit.edu	37	chr5	61779927	61779927	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatgtagaagattagtctCtcattatttcctattaactg	12	17	6	6	0	2	2	1	0	1	2	4	3	3	2	1	0	1	1	1	0	7	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:61779927C>G	uc003jtc.2	+	11	1302	c.1112C>G	c.(1111-1113)TCT>TGT	p.S371C	IPO11_uc011cqr.1_Missense_Mutation_p.S411C|IPO11_uc003jtb.1_Missense_Mutation_p.S371C	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	371						cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		AGATTAGTCTCTCATTATTTC	0.343													6	159					0	0	0	0	G	61779927	G	G	61779927	3	3	36	1	0	0	0	0	1	0	0	0	7832	913	32	2	1274	2	IPO11	5	61779927	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	7210794	61779927	119135333	296	7096											
TRIM23	373	broad.mit.edu	37	chr5	64910040	64910040	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttcaatccccagacacctGaatcacctagaataaatata	16	11	3	11	0	2	3	2	1	0	2	3	3	3	3	4	0	0	0	4	0	8	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:64910040G>C	uc003jty.2	-	3	337	c.251C>G	c.(250-252)TCA>TGA	p.S84*	TRIM23_uc003jtw.2_Nonsense_Mutation_p.S84*|TRIM23_uc003jtx.2_Nonsense_Mutation_p.S84*	NM_001656	NP_001647	P36406	TRI23_HUMAN	ADP-ribosylation factor domain protein 1 isoform	84					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		CCAGACACCTGAATCACCTAG	0.328													47	101					0	0	0	0	C	64910040	C	C	64910040	4	2	36	1	0	0	0	0	0	1	0	0	16564	1294	45	2	1576	2	TRIM23	5	64910040	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3130113	64910040	116005220	297	7097											
CD180	4064	broad.mit.edu	37	chr5	66479408	66479408	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccaaatcgaggagttctagCtgaggacattctttgaatgc	11	11	11	8	1	2	2	0	2	2	0	3	5	2	4	1	2	2	2	1	2	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:66479408C>G	uc003juy.2	-	3	1411	c.1263G>C	c.(1261-1263)CAG>CAC	p.Q421H		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	421	LRR 14.|Extracellular (Potential).				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		GGAGTTCTAGCTGAGGACATT	0.458													78	221					0	0	0	0	G	66479408	G	G	66479408	3	3	36	1	0	0	0	0	1	0	0	0	2987	796	28	4	726	4	CD180	5	66479408	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1569368	66479408	114435852	298	7098											
RGNEF	64283	broad.mit.edu	37	chr5	73205267	73205267	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccattcaggacagccacattGagatccacaggctggttctc	10	9	9	13	0	2	1	1	1	1	1	4	3	3	2	3	3	1	2	3	3	0	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:73205267G>C	uc011csq.1	+	33	4203	c.4192G>C	c.(4192-4194)GAG>CAG	p.E1398Q	RGNEF_uc003kcx.2_Missense_Mutation_p.E1398Q|RGNEF_uc010izf.2_Missense_Mutation_p.E1398Q|RGNEF_uc011csr.1_Missense_Mutation_p.E1085Q|RGNEF_uc003kcz.3_Missense_Mutation_p.E362Q|RGNEF_uc003kda.3_Missense_Mutation_p.E318Q	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	1398					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		CAGCCACATTGAGATCCACAG	0.567													7	28					0	0	0	0	C	73205267	C	C	73205267	3	2	36	1	0	0	0	0	1	0	0	0	13348	1291	45	2	4322	2	RGNEF	5	73205267	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	6725859	73205267	107709993	299	7099											
POLK	51426	broad.mit.edu	37	chr5	74892778	74892778	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctactgtttcattggaaaacGaagatgttggatcatttaga	13	14	9	5	1	2	2	2	0	0	2	2	5	2	4	0	2	2	2	0	2	5	6	rs143539365	byFrequency	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:74892778G>A	uc003kdw.2	+	13	2356	c.2260G>A	c.(2260-2262)GAA>AAA	p.E754K	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc010izq.2_Missense_Mutation_p.E556K|POLK_uc003kec.2_Missense_Mutation_p.E664K|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Intron|POLK_uc003kee.2_Intron|POLK_uc003kef.2_Missense_Mutation_p.E664K	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	754					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		ATTGGAAAACGAAGATGTTGG	0.368								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					13	204					0	0	0	0	A	74892778	A	A	74892778	3	1	36	1	0	0	0	0	1	0	0	0	12259	1059	37	1	2306	1	POLK	5	74892778	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1687511	74892778	106022482	300	7100											
PDE8B	8622	broad.mit.edu	37	chr5	76700610	76700610	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgtgaaatcgatatcatctCgaggcagtgatggtaagatg	13	10	12	6	3	2	3	1	2	1	1	4	5	2	3	0	2	0	2	0	2	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:76700610C>T	uc003kfa.2	+	12	1321	c.1276C>T	c.(1276-1278)CGA>TGA	p.R426*	PDE8B_uc003kfb.2_Nonsense_Mutation_p.R406*|PDE8B_uc003kfc.2_Nonsense_Mutation_p.R426*|PDE8B_uc003kfd.2_Nonsense_Mutation_p.R379*|PDE8B_uc003kfe.2_Nonsense_Mutation_p.R329*	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	426					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GATATCATCTCGAGGCAGTGA	0.353													18	76					0	0	0	0	T	76700610	T	T	76700610	4	4	36	1	0	0	0	0	0	1	0	0	11708	876	31	1	1322	1	PDE8B	5	76700610	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1807832	76700610	104214650	301	7101											
CMYA5	202333	broad.mit.edu	37	chr5	79034791	79034791	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcactagaagaacctaaaatCctggtcccacctgagccaag	14	7	7	13	0	1	3	1	1	0	2	3	3	3	3	5	1	2	0	5	1	6	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:79034791C>T	uc003kgc.2	+	2	10275	c.10203C>T	c.(10201-10203)ATC>ATT	p.I3401I		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3401						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AACCTAAAATCCTGGTCCCAC	0.453													30	101					0	0	0	0	T	79034791	T	T	79034791	2	4	36	1	0	0	0	0	0	0	0	1	3605	845	30	2		2	CMYA5	5	79034791	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2334181	79034791	101880469	302	7102											
THBS4	7060	broad.mit.edu	37	chr5	79366996	79366996	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgtgatgatgacatggaTggagatggtagatttatctt	10	14	13	4	0	1	5	0	3	1	2	1	7	1	6	1	3	0	1	1	3	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:79366996T>A	uc003kgh.2	+	14	2036	c.1713T>A	c.(1711-1713)GAT>GAA	p.D571E	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	571	TSP type-3 4.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		ATGACATGGATGGAGATGGTA	0.423													62	223					0	0	0	0	A	79366996	A	A	79366996	3	1	36	1	0	0	0	0	1	0	0	0	15922	1461	51	5	1763	5	THBS4	5	79366996	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	332205	79366996	101548264	303	7103											
RASA1	5921	broad.mit.edu	37	chr5	86564372	86564372	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcctatcccgcagtgtgtcGggtgaagatacccgcggccc	6	8	13	14	4	0	2	0	1	0	1	2	2	1	2	4	2	2	1	4	2	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:86564372G>T	uc003kiw.2	+	1	222	c.104G>T	c.(103-105)CGG>CTG	p.R35L	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_5'Flank|RASA1_uc011ctv.1_5'Flank|RASA1_uc011ctw.1_5'Flank|RASA1_uc010jaw.2_5'Flank|RASA1_uc011ctu.1_Missense_Mutation_p.R35L	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	35					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		GCAGTGTGTCGGGTGAAGATA	0.721													4	2					5.9392e-07	6.11403e-07	1	0	T	86564372	T	T	86564372	3	4	36	1	0	0	0	0	1	0	0	0	13125	1116	39	3	106	3	RASA1	5	86564372	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	7197376	86564372	94350888	304	7104											
GPR98	84059	broad.mit.edu	37	chr5	89981767	89981767	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaacaggaggagcatttgcaGatgtctctgtgaagtttaaa	13	11	12	5	0	1	2	0	1	1	1	2	5	1	4	0	2	3	3	0	2	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:89981767G>C	uc003kju.2	+	29	6541	c.6445G>C	c.(6445-6447)GAT>CAT	p.D2149H	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2149	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGCATTTGCAGATGTCTCTGT	0.428													6	29					0	0	0	0	C	89981767	C	C	89981767	3	2	36	1	0	0	0	0	1	0	0	0	6760	942	33	2	6559	2	GPR98	5	89981767	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3417395	89981767	90933493	305	7105											
FAM81B	153643	broad.mit.edu	37	chr5	94784011	94784011	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atggaagaaaaactgctgcaGctttcaagcaaagtagagaa	18	7	10	6	0	1	2	1	0	0	2	1	4	1	3	0	1	5	5	0	1	7	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:94784011G>C	uc003kla.1	+	9	1114	c.1068G>C	c.(1066-1068)CAG>CAC	p.Q356H	FAM81B_uc010jbe.1_Missense_Mutation_p.Q152H	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	356	Potential.									ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		AACTGCTGCAGCTTTCAAGCA	0.313													9	52					0	0	0	0	C	94784011	C	C	94784011	3	2	36	1	0	0	0	0	1	0	0	0	5661	962	34	4	1102	4	FAM81B	5	94784011	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4802244	94784011	86131249	306	7106											
ERAP2	64167	broad.mit.edu	37	chr5	96219594	96219594	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caacttttcaatcaagatacGaagagagagcaggcatattg	16	9	9	7	1	2	3	2	0	0	3	2	5	2	3	0	1	3	2	0	1	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:96219594G>A	uc003kmq.2	+	3	1384	c.674G>A	c.(673-675)CGA>CAA	p.R225Q	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.R225Q|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.R219Q|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	225	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		ATCAAGATACGAAGAGAGAGC	0.418													20	84					0	0	0	0	A	96219594	A	A	96219594	3	1	36	1	0	0	0	0	1	0	0	0	5228	1058	37	1	680	1	ERAP2	5	96219594	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1435583	96219594	84695666	307	7107											
MAN2A1	4124	broad.mit.edu	37	chr5	109181672	109181672	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatcgtttgacactgctctCtgctcagtcattaggggttt	7	15	9	10	1	3	1	2	1	1	0	5	1	3	1	0	2	2	4	0	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:109181672C>G	uc003kou.1	+	18	3770	c.2807C>G	c.(2806-2808)TCT>TGT	p.S936C		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	936	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		ACACTGCTCTCTGCTCAGTCA	0.413													8	299					0	0	0	0	G	109181672	G	G	109181672	3	3	36	1	0	0	0	0	1	0	0	0	9267	913	32	2	2877	2	MAN2A1	5	109181672	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	12962078	109181672	71733588	308	7108											
STARD4	134429	broad.mit.edu	37	chr5	110836745	110836745	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccacagtataggagaaatCaacaaattctcttggggaaa	16	8	9	8	0	2	1	1	0	1	1	3	3	2	2	1	3	1	1	1	3	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:110836745C>G	uc003kph.1	-	5	436	c.352G>C	c.(352-354)GAT>CAT	p.D118H	STARD4_uc010jbw.1_Missense_Mutation_p.D20H|STARD4_uc010jbx.1_Missense_Mutation_p.D20H|STARD4_uc003kpi.1_Intron|STARD4_uc003kpj.2_Missense_Mutation_p.D118H	NM_139164	NP_631903	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain	118	START.				lipid transport		lipid binding			ovary(1)	1		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		TAGGAGAAATCAACAAATTCT	0.338													56	224					0	0	0	0	G	110836745	G	G	110836745	3	3	36	1	0	0	0	0	1	0	0	0	15325	826	29	2	273	2	STARD4	5	110836745	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1655073	110836745	70078515	309	7109											
APC	324	broad.mit.edu	37	chr5	112177508	112177508	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaatatgggtggcatattaGgtgaagatctgacacttgat	13	12	12	4	0	1	4	0	3	1	1	1	5	1	4	0	3	0	1	0	3	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:112177508G>A	uc010jby.2	+	16	6597	c.6217G>A	c.(6217-6219)GGT>AGT	p.G2073S	APC_uc011cvt.1_Missense_Mutation_p.G2055S|APC_uc003kpz.3_Missense_Mutation_p.G2073S|APC_uc003kpy.3_Missense_Mutation_p.G2073S|APC_uc010jbz.2_Missense_Mutation_p.G1790S|APC_uc010jca.2_Missense_Mutation_p.G1373S	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2073	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TGGCATATTAGGTGAAGATCT	0.383		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			49	114					0	0	0	0	A	112177508	A	A	112177508	3	1	36	1	0	0	0	0	1	0	0	0	763	1000	35	4	6275	4	APC	5	112177508	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1340763	112177508	68737752	310	7110											
APC	324	broad.mit.edu	37	chr5	112179224	112179224	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgaatcaaagactctaattTatcaaatggcacctgctgtt	13	13	6	9	0	3	2	2	1	1	1	3	2	3	2	1	1	1	3	1	1	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:112179224T>C	uc010jby.2	+	16	8313	c.7933T>C	c.(7933-7935)TAT>CAT	p.Y2645H	APC_uc011cvt.1_Missense_Mutation_p.Y2627H|APC_uc003kpz.3_Missense_Mutation_p.Y2645H|APC_uc003kpy.3_Missense_Mutation_p.Y2645H|APC_uc010jbz.2_Missense_Mutation_p.Y2362H|APC_uc010jca.2_Missense_Mutation_p.Y1945H	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2645	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GACTCTAATTTATCAAATGGC	0.388		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			92	165					0	0	0	0	C	112179224	C	C	112179224	3	2	36	1	0	0	0	0	1	0	0	0	763	1754	61	5	7991	5	APC	5	112179224	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	1716	112179224	68736036	311	7111											
AQPEP	206338	broad.mit.edu	37	chr5	115361749	115361749	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaacttacagacaataaaGaatgaaaatctgaaaaacaa	23	6	5	7	0	1	4	0	2	1	2	1	4	1	4	1	0	3	0	1	0	11	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:115361749G>A	uc003kro.2	+	20	3071	c.2907G>A	c.(2905-2907)AAG>AAA	p.K969K	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	969	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						AGACAATAAAGAATGAAAATC	0.433													4	91					0	0	0	0	A	115361749	A	A	115361749	2	1	36	1	0	0	0	0	0	0	0	1	834	933	33	2		2	AQPEP	5	115361749	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3182525	115361749	65553511	312	7112											
DTWD2	285605	broad.mit.edu	37	chr5	118176651	118176651	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attaacaattccattttcctGagtttgcgtttgttctttgg	7	20	7	7	1	1	1	0	1	1	0	3	1	3	1	2	1	2	3	2	1	2	8	rs138333410		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:118176651G>C	uc003ksa.2	-	6	892	c.858C>G	c.(856-858)CTC>CTG	p.L286L		NM_173666	NP_775937	Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	286											0		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)		CCATTTTCCTGAGTTTGCGTT	0.348													8	65					0	0	0	0	C	118176651	C	C	118176651	2	2	36	1	0	0	0	0	0	0	0	1	4814	1277	45	2		2	DTWD2	5	118176651	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2814902	118176651	62738609	313	7113											
PRR16	51334	broad.mit.edu	37	chr5	120021840	120021840	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgctatcctcacggtcctGagaaagccaaaccctccacc	10	8	6	17	1	2	1	1	1	1	1	5	2	5	1	6	1	3	1	6	1	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:120021840G>A	uc003ksq.2	+	2	514	c.351G>A	c.(349-351)CTG>CTA	p.L117L	PRR16_uc003ksp.2_Silent_p.L94L|PRR16_uc003ksr.2_Silent_p.L47L	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	117	Pro-rich.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		TCACGGTCCTGAGAAAGCCAA	0.522													45	91					0	0	0	0	A	120021840	A	A	120021840	2	1	36	1	0	0	0	0	0	0	0	1	12651	1277	45	2		2	PRR16	5	120021840	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1845189	120021840	60893420	314	7114											
ZNF608	57507	broad.mit.edu	37	chr5	123983566	123983566	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccttggagtcctctagtttCcccagcttggcatccatttt	5	15	7	14	0	1	0	0	0	1	0	4	1	4	1	5	2	1	3	5	2	1	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:123983566C>A	uc003ktq.1	-	4	2634	c.2511G>T	c.(2509-2511)GGG>GGT	p.G837G	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Silent_p.G837G|ZNF608_uc003ktt.1_Silent_p.G837G	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	837						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CCTCTAGTTTCCCCAGCTTGG	0.463													91	263					8.03987e-26	8.59458e-26	1	0	A	123983566	A	A	123983566	2	1	36	1	0	0	0	0	0	0	0	1	18101	842	30	2		2	ZNF608	5	123983566	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3961726	123983566	56931694	315	7115											
ALDH7A1	501	broad.mit.edu	37	chr5	125928409	125928409	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttacagtttcttcatagtCtgccacactggcctaaatta	10	15	5	11	0	3	0	1	0	2	0	3	0	3	0	2	1	2	1	2	1	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:125928409C>G	uc003ktx.2	-	3	451	c.259G>C	c.(259-261)GAC>CAC	p.D87H	ALDH7A1_uc003kty.2_RNA|ALDH7A1_uc011cxa.1_Missense_Mutation_p.D114H|ALDH7A1_uc003ktz.2_Missense_Mutation_p.D114H	NM_001182	NP_001173	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	87					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			kidney(2)|ovary(1)	3		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	TCTTCATAGTCTGCCACACTG	0.368													10	41					0	0	0	0	G	125928409	G	G	125928409	3	3	36	1	0	0	0	0	1	0	0	0	504	913	32	2	1424	2	ALDH7A1	5	125928409	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1944843	125928409	54986851	316	7116											
PHAX	51808	broad.mit.edu	37	chr5	125939416	125939416	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgtctttggaaacgcaaacGacagaaatgttttaaccctc	13	11	7	10	2	1	1	0	0	1	1	2	3	1	2	1	1	3	2	1	1	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:125939416G>C	uc003kua.1	+	2	273	c.251G>C	c.(250-252)CGA>CCA	p.R84P		NM_032177	NP_115553	Q9H814	PHAX_HUMAN	RNA U, small nuclear RNA export adaptor	84	Necessary for interaction with CBP80 (By similarity).|Nuclear localization signal (By similarity).				ncRNA metabolic process|protein transport|snRNA export from nucleus|spliceosomal snRNP assembly	Cajal body|cytosol	RNA binding				0						AAACGCAAACGACAGAAATGT	0.418													18	116					0	0	0	0	C	125939416	C	C	125939416	3	2	36	1	0	0	0	0	1	0	0	0	11868	1058	37	3	257	3	PHAX	5	125939416	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	11007	125939416	54975844	317	7117											
CATSPER3	347732	broad.mit.edu	37	chr5	134344589	134344589	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgggaatttgctttgagccGggcattcaccatcatcttca	8	13	9	11	2	4	1	3	1	1	0	5	2	4	2	2	2	2	2	2	2	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:134344589G>T	uc003lag.2	+	5	802	c.734G>T	c.(733-735)CGG>CTG	p.R245L		NM_178019	NP_821138	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	245	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCTTTGAGCCGGGCATTCACC	0.532													32	92					3.80469e-20	4.05304e-20	1	0	T	134344589	T	T	134344589	3	4	36	1	0	0	0	0	1	0	0	0	2701	1116	39	3	752	3	CATSPER3	5	134344589	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	8405173	134344589	46570671	318	7118											
FAM13B	51306	broad.mit.edu	37	chr5	137275949	137275949	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaatcttgtttgcttataaGaacttcaagaagcctaagct	14	13	7	7	0	2	3	1	0	1	3	2	3	2	3	1	0	4	3	1	0	7	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:137275949G>C	uc003lbz.2	-	23	3247	c.2713C>G	c.(2713-2715)CTT>GTT	p.L905V	FAM13B_uc003lcb.2_Missense_Mutation_p.L781V|FAM13B_uc003lca.2_Missense_Mutation_p.L877V|PKD2L2_uc003lbw.1_3'UTR|PKD2L2_uc003lbx.2_3'UTR|PKD2L2_uc003lby.2_Intron|PKD2L2_uc011cyi.1_3'UTR	NM_016603	NP_057687	Q9NYF5	FA13B_HUMAN	hypothetical protein LOC51306 isoform 1	905					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						TTGCTTATAAGAACTTCAAGA	0.373													28	67					0	0	0	0	C	137275949	C	C	137275949	3	2	36	1	0	0	0	0	1	0	0	0	5481	942	33	2	38	2	FAM13B	5	137275949	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2931360	137275949	43639311	319	7119											
NDUFA2	4695	broad.mit.edu	37	chr5	140026901	140026901	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcggattaggatgggtaggtCgggattcgccttcttcagct	6	12	15	8	3	2	0	1	0	1	0	4	3	2	3	1	5	1	2	1	5	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:140026901C>T	uc003lgp.2	-	2	220	c.148G>A	c.(148-150)GAC>AAC	p.D50N	IK_uc011czk.1_5'Flank|IK_uc003lgq.2_5'Flank	NM_002488	NP_002479	O43678	NDUA2_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	50			D -> N (in a breast cancer sample; somatic mutation).		mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity	p.D50N(1)		breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		NADH(DB00157)	ATGGGTAGGTCGGGATTCGCC	0.662													6	81					0	0	0	0	T	140026901	T	T	140026901	3	4	36	1	0	0	0	0	1	0	0	0	10318	884	31	1	186	1	NDUFA2	5	140026901	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2750952	140026901	40888359	320	7120											
PCDHAC2	56134	broad.mit.edu	37	chr5	140348753	140348753	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcctgtctgacagcaggctCagggagtgacactttcatgt	8	10	13	10	0	3	2	2	2	1	0	3	3	3	3	1	3	1	2	1	3	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:140348753C>G	uc003lii.2	+	1	2642	c.2402C>G	c.(2401-2403)TCA>TGA	p.S801*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Nonsense_Mutation_p.S801*	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	801	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGCAGGCTCAGGGAGTGAC	0.552													16	109					0	0	0	0	G	140348753	G	G	140348753	4	3	36	1	0	0	0	0	0	1	0	0	11587	838	29	2	2404	2	PCDHAC2	5	140348753	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	321852	140348753	40566507	321	7121											
PCDHB2	56133	broad.mit.edu	37	chr5	140474836	140474836	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcactcctggaactactttCttaatagaacgtgcccagga	12	11	7	11	1	2	1	1	0	1	1	3	3	3	3	2	2	4	0	2	2	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:140474836C>G	uc003lil.2	+	1	600	c.462C>G	c.(460-462)TTC>TTG	p.F154L	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	154	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAACTACTTTCTTAATAGAAC	0.393													12	58					0	0	0	0	G	140474836	G	G	140474836	3	3	36	1	0	0	0	0	1	0	0	0	11596	912	32	2	464	2	PCDHB2	5	140474836	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	126083	140474836	40440424	322	7122											
PCDHB3	56132	broad.mit.edu	37	chr5	140481673	140481673	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgccacagacagagactcAggcaccaacgcccaggtaac	14	2	10	15	2	1	2	1	0	0	2	1	3	1	2	3	2	3	2	3	2	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:140481673A>G	uc003lio.2	+	1	1440	c.1440A>G	c.(1438-1440)TCA>TCG	p.S480S	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	480	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAGAGACTCAGGCACCAACG	0.647													44	128					0	0	0	0	G	140481673	G	G	140481673	2	3	36	1	0	0	0	0	0	0	0	1	11597	175	7	5		5	PCDHB3	5	140481673	Silent	SNP	A	TCGA-CN-4723-01A-01D-1434-08	6837	140481673	40433587	323	7123											
PCDHB14	56122	broad.mit.edu	37	chr5	140604130	140604130	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagaagtgaccatatcgtcGattacaaagagaattccaga	16	8	8	9	2	0	4	0	1	0	3	3	6	1	4	3	0	1	0	3	0	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:140604130G>A	uc003ljb.2	+	1	1053	c.1053G>A	c.(1051-1053)TCG>TCA	p.S351S	PCDHB14_uc011dal.1_Silent_p.S198S	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	351	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCATATCGTCGATTACAAAGA	0.428													37	82					0	0	0	0	A	140604130	A	A	140604130	2	1	36	1	0	0	0	0	0	0	0	1	11593	1045	37	1		1	PCDHB14	5	140604130	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	122457	140604130	40311130	324	7124											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720878	140720878	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactatgcggacacgctcatCagccaggagagctgtgagaa	13	6	12	10	2	2	2	2	1	0	2	2	5	2	3	1	2	4	2	1	2	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:140720878C>T	uc003ljk.1	+	1	2525	c.2340C>T	c.(2338-2340)ATC>ATT	p.I780I	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Silent_p.I780I|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	780	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACGCTCATCAGCCAGGAGA	0.498													47	133					0	0	0	0	T	140720878	T	T	140720878	2	4	36	1	0	0	0	0	0	0	0	1	11608	816	29	2		2	PCDHGA2	5	140720878	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	116748	140720878	40194382	325	7125											
PCDHGB1	56104	broad.mit.edu	37	chr5	140732048	140732048	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggttcctcccaaccacagcGaggggactttgccctattcc	7	9	10	15	1	0	0	0	0	0	0	3	2	3	1	5	3	3	1	5	3	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:140732048G>A	uc003ljo.1	+	1	2221	c.2221G>A	c.(2221-2223)GAG>AAG	p.E741K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA4_uc003ljq.1_5'Flank|PCDHGB1_uc011daq.1_Missense_Mutation_p.E741K|PCDHGA4_uc003ljp.1_5'Flank	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	741	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACCACAGCGAGGGGACTTT	0.562													27	129					0	0	0	0	A	140732048	A	A	140732048	3	1	36	1	0	0	0	0	1	0	0	0	11616	1059	37	1	2223	1	PCDHGB1	5	140732048	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	11170	140732048	40183212	326	7126											
PCDHGA6	56109	broad.mit.edu	37	chr5	140755614	140755614	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccacggccagccccctctctCcgccactgtcacgctcaccg	5	6	7	23	4	3	0	2	0	1	0	5	0	4	0	7	1	1	1	7	1	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:140755614C>T	uc003ljy.1	+	1	1964	c.1964C>T	c.(1963-1965)TCC>TTC	p.S655F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.S655F	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	655	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCCTCTCTCCGCCACTGTC	0.706													8	40					0	0	0	0	T	140755614	T	T	140755614	3	4	36	1	0	0	0	0	1	0	0	0	11612	855	30	2	1966	2	PCDHGA6	5	140755614	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	23566	140755614	40159646	327	7127											
PCDHGB4	8641	broad.mit.edu	37	chr5	140768392	140768392	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaagaagtcaaagaatattCcatagttttggaagcaaggg	16	10	11	4	0	1	3	1	1	0	2	2	4	2	4	1	2	1	2	1	2	8	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:140768392C>A	uc003lkc.1	+	1	941	c.941C>A	c.(940-942)TCC>TAC	p.S314Y	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.S314Y	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	314	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAGAATATTCCATAGTTTTG	0.408													38	35					5.04308e-16	5.33051e-16	1	0	A	140768392	A	A	140768392	3	1	36	1	0	0	0	0	1	0	0	0	11619	855	30	2	943	2	PCDHGB4	5	140768392	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	12778	140768392	40146868	328	7128											
YIPF5	81555	broad.mit.edu	37	chr5	143544999	143544999	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgcaacaaatcttaccttCtaataaaggtggctcatcct	12	13	6	10	0	3	0	1	0	2	0	4	0	4	0	2	2	3	3	2	2	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:143544999C>T	uc003lnk.3	-	3	721	c.280G>A	c.(280-282)GAA>AAA	p.E94K	YIPF5_uc003lnl.3_Missense_Mutation_p.E94K|YIPF5_uc010jgl.2_Missense_Mutation_p.E40K	NM_001024947	NP_001020118	Q969M3	YIPF5_HUMAN	Yip1 domain family, member 5	94	Cytoplasmic (Potential).|Interaction with Sec23.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi cisterna membrane|integral to membrane				ovary(1)|skin(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			ATCTTACCTTCTAATAAAGGT	0.378													18	105					0	0	0	0	T	143544999	T	T	143544999	3	4	36	1	0	0	0	0	1	0	0	0	17549	922	32	2	509	2	YIPF5	5	143544999	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2776607	143544999	37370261	329	7129											
TNIP1	10318	broad.mit.edu	37	chr5	150415257	150415257	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccctctggaagtcctcctcGaagatcttcacctggtgtgg	6	12	10	13	1	3	1	1	0	2	1	7	3	6	2	4	3	0	0	4	3	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:150415257G>A	uc003ltf.2	-	14	1996	c.1407C>T	c.(1405-1407)TTC>TTT	p.F469F	TNIP1_uc011dcn.1_5'UTR|TNIP1_uc010jhl.2_RNA|TNIP1_uc010jhm.2_Silent_p.F469F|TNIP1_uc010jhn.2_Silent_p.F469F|TNIP1_uc011dco.1_Silent_p.F469F|TNIP1_uc003lth.2_RNA|TNIP1_uc003lti.2_Silent_p.F469F|TNIP1_uc003ltg.2_Silent_p.F416F|TNIP1_uc003ltj.2_Silent_p.F469F|TNIP1_uc010jho.1_RNA|TNIP1_uc010jhq.1_Silent_p.F416F|TNIP1_uc010jhp.1_Silent_p.F416F|TNIP1_uc010jhr.1_Silent_p.F469F|TNIP1_uc003ltk.2_Silent_p.F469F	NM_006058	NP_006049	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	469	Potential.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTCCTCCTCGAAGATCTTCA	0.597													4	132					0	0	0	0	A	150415257	A	A	150415257	2	1	36	1	0	0	0	0	0	0	0	1	16380	1049	37	1		1	TNIP1	5	150415257	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	6870258	150415257	30500003	330	7130											
SLC36A3	285641	broad.mit.edu	37	chr5	150664219	150664219	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggctgtaccaaagaacagCaagaaggtcttccagtttgc	13	9	10	9	0	1	2	0	0	1	2	2	2	2	2	2	2	4	4	2	2	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:150664219C>T	uc003ltw.2	-	7	1181	c.762G>A	c.(760-762)TTG>TTA	p.L254L	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Silent_p.L239L|SLC36A3_uc003ltx.2_Silent_p.L295L	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	254	Helical; (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAAAGAACAGCAAGAAGGTCT	0.493													30	109					0	0	0	0	T	150664219	T	T	150664219	2	4	36	1	0	0	0	0	0	0	0	1	14659	709	25	4		4	SLC36A3	5	150664219	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	248962	150664219	30251041	331	7131											
GALNT10	55568	broad.mit.edu	37	chr5	153755896	153755896	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccccagtgtgaggattcttCgaaccaagaaacgggaaggg	12	7	13	9	2	1	2	0	1	1	1	3	5	2	4	3	3	2	0	3	3	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:153755896C>T	uc003lvh.2	+	5	760	c.628C>T	c.(628-630)CGA>TGA	p.R210*	GALNT10_uc003lvg.1_Nonsense_Mutation_p.R210*|GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Intron	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	210	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GAGGATTCTTCGAACCAAGAA	0.502													60	179					0	0	0	0	T	153755896	T	T	153755896	4	4	36	1	0	0	0	0	0	1	0	0	6243	876	31	1	646	1	GALNT10	5	153755896	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3091677	153755896	27159364	332	7132											
SAP30L	79685	broad.mit.edu	37	chr5	153835558	153835558	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacaagagtagactggaccaGaaatcggagggtggcaagca	16	4	14	7	1	0	3	0	0	0	3	1	5	0	5	1	4	2	3	1	4	5	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:153835558G>C	uc003lvk.2	+	4	1170	c.522G>C	c.(520-522)CAG>CAC	p.Q174H	SAP30L_uc003lvm.3_RNA|SAP30L_uc011ddc.1_Missense_Mutation_p.Q133H|SAP30L_uc011ddd.1_Missense_Mutation_p.Q128H	NM_024632	NP_078908	Q9HAJ7	SP30L_HUMAN	SAP30-like isoform 1	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|metal ion binding				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GACTGGACCAGAAATCGGAGG	0.438													37	163					0	0	0	0	C	153835558	C	C	153835558	3	2	36	1	0	0	0	0	1	0	0	0	13900	933	33	2	536	2	SAP30L	5	153835558	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	79662	153835558	27079702	333	7133											
TIMD4	91937	broad.mit.edu	37	chr5	156381666	156381666	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcactggtctttcccccAgcacatgctgttgctgttgt	4	13	12	12	0	1	0	0	0	1	0	2	0	2	0	2	3	3	6	2	3	0	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:156381666A>T	uc003lwh.2	-	2	217	c.160T>A	c.(160-162)TGG>AGG	p.W54R	TIMD4_uc010jii.2_Missense_Mutation_p.W54R	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	54	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTTTCCCCCAGCACATGCTG	0.527													35	85					0	0	0	0	T	156381666	T	T	156381666	3	4	36	1	0	0	0	0	1	0	0	0	15969	188	7	5	1008	5	TIMD4	5	156381666	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	2546108	156381666	24533594	334	7134											
SOX30	11063	broad.mit.edu	37	chr5	157078561	157078561	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgtcccctcggaagtagcCgagggccggcccggggcctt	4	6	15	16	5	0	0	0	0	0	0	3	2	1	1	6	5	1	1	6	5	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:157078561C>G	uc003lxb.1	-	1	868	c.526G>C	c.(526-528)GGC>CGC	p.G176R	SOX30_uc003lxc.1_Missense_Mutation_p.G176R|SOX30_uc011dds.1_Intron	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	176					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CGGAAGTAGCCGAGGGCCGGC	0.677													55	93					0	0	0	0	G	157078561	G	G	157078561	3	3	36	1	0	0	0	0	1	0	0	0	15016	652	23	3	1755	3	SOX30	5	157078561	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	696895	157078561	23836699	335	7135											
ODZ2	57451	broad.mit.edu	37	chr5	167627019	167627019	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttcacctgatggtggctGtcgaggggcatctcttccag	5	11	15	10	1	2	1	1	1	1	0	5	2	3	1	2	5	0	3	2	5	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:167627019G>T	uc010jjd.2	+	17	3286	c.3286G>T	c.(3286-3288)GTC>TTC	p.V1096F	ODZ2_uc003lzr.3_Missense_Mutation_p.V873F|ODZ2_uc003lzt.3_Missense_Mutation_p.V469F|ODZ2_uc010jje.2_Missense_Mutation_p.V367F	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GATGGTGGCTGTCGAGGGGCA	0.537													18	64					1.02788e-11	1.07257e-11	1	0	T	167627019	T	T	167627019	3	4	36	1	0	0	0	0	1	0	0	0	10889	1377	48	4	3352	4	ODZ2	5	167627019	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	10548458	167627019	13288241	336	7136											
WWC1	23286	broad.mit.edu	37	chr5	167812224	167812224	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtctgttccagaaaccactCagattgaggatcctcgagta	11	10	10	10	1	2	3	1	1	1	2	5	5	4	4	3	2	1	2	3	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:167812224C>G	uc003lzu.2	+	3	331	c.238C>G	c.(238-240)CAG>GAG	p.Q80E	WWC1_uc003lzv.2_Missense_Mutation_p.Q80E|WWC1_uc011den.1_Missense_Mutation_p.Q80E	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	80	WW 2.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		AGAAACCACTCAGATTGAGGA	0.507													19	40					0	0	0	0	G	167812224	G	G	167812224	3	3	36	1	0	0	0	0	1	0	0	0	17479	827	29	2	248	2	WWC1	5	167812224	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	185205	167812224	13103036	337	7137											
CCDC99	54908	broad.mit.edu	37	chr5	169020507	169020507	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggaaagcatgtcttcagaGatgctggctcttcaaattga	12	11	10	8	0	4	2	2	1	2	1	4	4	4	3	0	2	2	3	0	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:169020507G>C	uc003mae.3	+	4	765	c.486G>C	c.(484-486)GAG>GAC	p.E162D	CCDC99_uc010jjj.2_Missense_Mutation_p.E91D|CCDC99_uc011deq.1_Intron|CCDC99_uc010jjk.2_5'UTR	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	162	Potential.				cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTCTTCAGAGATGCTGGCTC	0.413													26	108					0	0	0	0	C	169020507	C	C	169020507	3	2	36	1	0	0	0	0	1	0	0	0	2889	933	33	2	496	2	CCDC99	5	169020507	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1208283	169020507	11894753	338	7138											
ADAMTS2	9509	broad.mit.edu	37	chr5	178771042	178771042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccggaccggggcggccctgCgggctcgtacccctgctctg	2	7	15	17	5	1	0	0	0	1	0	3	1	2	1	5	5	3	3	5	5	1	1	rs150047440		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:178771042C>T	uc003mjw.2	-	2	260	c.260G>A	c.(259-261)CGC>CAC	p.R87H	ADAMTS2_uc011dgm.1_Missense_Mutation_p.R87H	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	87					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GGCGGCCCTGCGGGCTCGTAC	0.697													18	39					0	0	0	0	T	178771042	T	T	178771042	3	4	36	1	0	0	0	0	1	0	0	0	265	768	27	1	3534	1	ADAMTS2	5	178771042	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	9750535	178771042	2144218	339	7139											
MAPK9	5601	broad.mit.edu	37	chr5	179696288	179696288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacataacttacatttttatGattgacacattttaagagga	15	16	5	5	0	0	3	0	2	0	1	0	4	0	4	0	1	3	0	0	1	5	9			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:179696288G>A	uc003mls.3	-	3	515	c.244C>T	c.(244-246)CAT>TAT	p.H82Y	MAPK9_uc003mlt.3_Missense_Mutation_p.H82Y|MAPK9_uc010jlc.2_Missense_Mutation_p.H82Y|MAPK9_uc003mlv.3_Missense_Mutation_p.H82Y|MAPK9_uc011dgx.1_Missense_Mutation_p.H82Y	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	82	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACATTTTTATGATTGACACAT	0.363													6	124					0	0	0	0	A	179696288	A	A	179696288	3	1	36	1	0	0	0	0	1	0	0	0	9340	1290	45	2	1192	2	MAPK9	5	179696288	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	925246	179696288	1218972	340	7140											
BTNL8	79908	broad.mit.edu	37	chr5	180338384	180338384	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcacgggatatgttgataGagacatccagctactctgtc	11	11	9	10	1	2	2	1	1	1	1	4	4	3	3	1	1	2	2	1	1	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:180338384G>C	uc003mmp.2	+	3	677	c.443G>C	c.(442-444)AGA>ACA	p.R148T	BTNL8_uc003mmq.2_Missense_Mutation_p.R148T|BTNL8_uc011dhg.1_Missense_Mutation_p.R23T|BTNL8_uc010jll.2_Missense_Mutation_p.R148T|BTNL8_uc010jlm.2_Missense_Mutation_p.R32T|BTNL8_uc011dhh.1_5'UTR	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	148	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TATGTTGATAGAGACATCCAG	0.537													144	412					0	0	0	0	C	180338384	C	C	180338384	3	2	36	1	0	0	0	0	1	0	0	0	1572	942	33	2	479	2	BTNL8	5	180338384	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	642096	180338384	576876	341	7141											
BTNL8	79908	broad.mit.edu	37	chr5	180377003	180377003	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccccaggaggtgcctcactCtgagaagagatttacaagga	12	8	11	10	0	2	2	1	1	1	2	3	6	3	4	3	3	2	0	3	3	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr5:180377003C>G	uc003mmp.2	+	8	1196	c.962C>G	c.(961-963)TCT>TGT	p.S321C	BTNL8_uc003mmq.2_3'UTR|BTNL8_uc011dhg.1_Missense_Mutation_p.S196C|BTNL8_uc010jll.2_3'UTR|BTNL8_uc010jlm.2_Missense_Mutation_p.S205C|BTNL8_uc011dhh.1_Missense_Mutation_p.S137C	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	321	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGCCTCACTCTGAGAAGAGA	0.517													35	92					0	0	0	0	G	180377003	G	G	180377003	3	3	36	1	0	0	0	0	1	0	0	0	1572	913	32	2	1148	2	BTNL8	5	180377003	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	38619	180377003	538257	342	7142											
JARID2	3720	broad.mit.edu	37	chr6	15496939	15496939	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aagtgccggagcgcagtctgGagaggaatcggccgaagcgg	10	4	18	9	5	1	1	0	0	1	1	2	5	1	3	2	5	3	1	2	5	3	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:15496939G>C	uc003nbj.2	+	7	1727	c.1483G>C	c.(1483-1485)GAG>CAG	p.E495Q	JARID2_uc011diu.1_Missense_Mutation_p.E359Q|JARID2_uc011div.1_Missense_Mutation_p.E323Q|JARID2_uc011diw.1_Missense_Mutation_p.E457Q	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	495					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				GCGCAGTCTGGAGAGGAATCG	0.662													26	26					0	0	0	0	C	15496939	C	C	15496939	3	2	36	1	0	0	0	0	1	0	0	0	7984	1175	41	2	1509	2	JARID2	6	15496939	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08		15496939	155618128	343	7143											
HIST1H2AC	8334	broad.mit.edu	37	chr6	26124521	26124521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagcgaaatcccgctcttctCgcgctggtctccagttcccg	6	10	9	16	5	3	0	0	0	3	0	7	1	5	0	3	1	1	3	3	1	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:26124521C>T	uc003ngm.2	+	1	149	c.61C>T	c.(61-63)CGC>TGC	p.R21C	HIST1H2BC_uc003ngk.3_5'Flank|HIST1H2BC_uc003ngl.2_5'Flank|HIST1H2AC_uc003ngn.2_RNA|HIST1H2AC_uc003ngo.2_RNA|HIST1H2AC_uc003ngp.2_Missense_Mutation_p.R21C	NM_003512	NP_003503	Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	21					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CCGCTCTTCTCGCGCTGGTCT	0.612													29	20					0	0	0	0	T	26124521	T	T	26124521	3	4	36	1	0	0	0	0	1	0	0	0	7169	884	31	1	63	1	HIST1H2AC	6	26124521	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	10627582	26124521	144990546	344	7144											
BTN2A2	10385	broad.mit.edu	37	chr6	26385375	26385375	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtggttccggtctcagttctCccccgcagtgtttgtgtata	4	15	11	11	2	2	0	1	0	2	0	5	0	3	0	3	2	0	5	3	2	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:26385375C>T	uc003nhq.2	+	3	313	c.227C>T	c.(226-228)TCC>TTC	p.S76F	BTN2A2_uc011dkf.1_Intron|BTN2A2_uc011dkg.1_Missense_Mutation_p.S76F|BTN2A2_uc003nhr.2_Intron|BTN2A2_uc011dkh.1_Intron|BTN2A2_uc003nhs.2_Missense_Mutation_p.S76F|BTN2A2_uc003nht.2_Missense_Mutation_p.S76F	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	76	Extracellular (Potential).|Ig-like V-type.				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						TCTCAGTTCTCCCCCGCAGTG	0.527													31	40					0	0	0	0	T	26385375	T	T	26385375	3	4	36	1	0	0	0	0	1	0	0	0	1566	855	30	2	233	2	BTN2A2	6	26385375	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	260854	26385375	144729692	345	7145											
ZSCAN16	80345	broad.mit.edu	37	chr6	28097416	28097416	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgaatgtgggaaaagtttCagtcatagctcagaccttag	13	11	11	6	0	3	2	3	1	0	1	3	4	3	3	1	1	1	2	1	1	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:28097416C>T	uc003nkm.2	+	4	835	c.735C>T	c.(733-735)TTC>TTT	p.F245F	uc010jqw.1_Intron|uc003nkk.1_Intron|uc003nkl.1_Intron	NM_025231	NP_079507	Q9H4T2	ZSC16_HUMAN	zinc finger and SCAN domain containing 16	245	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)	1						GGAAAAGTTTCAGTCATAGCT	0.418													44	52					0	0	0	0	T	28097416	T	T	28097416	2	4	36	1	0	0	0	0	0	0	0	1	18296	825	29	2		2	ZSCAN16	6	28097416	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1712041	28097416	143017651	346	7146											
ZNF323	64288	broad.mit.edu	37	chr6	28297298	28297298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggagccggctcagagcttCtcggggaccaggagtctctt	6	9	14	12	3	3	1	1	0	2	1	6	4	3	4	2	5	2	2	2	5	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:28297298C>T	uc003nla.2	-	2	563	c.163G>A	c.(163-165)GAA>AAA	p.E55K	ZNF323_uc003nld.2_Missense_Mutation_p.E55K|ZNF323_uc010jra.2_Missense_Mutation_p.E55K|ZNF323_uc003nlb.2_Intron|ZNF323_uc010jrb.2_Intron|ZNF323_uc003nlc.2_Missense_Mutation_p.E55K	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	55	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CTCAGAGCTTCTCGGGGACCA	0.522													126	195					0	0	0	0	T	28297298	T	T	28297298	3	4	36	1	0	0	0	0	1	0	0	0	17910	922	32	2	1069	2	ZNF323	6	28297298	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	199882	28297298	142817769	347	7147											
SCAND3	114821	broad.mit.edu	37	chr6	28541483	28541483	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtgaaactagcatgaactCttttggttttcccttcttca	9	16	7	9	0	3	2	1	2	2	0	4	3	4	2	1	1	3	2	1	1	3	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:28541483C>G	uc003nlo.2	-	4	2801	c.2183G>C	c.(2182-2184)AGA>ACA	p.R728T		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	728					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						agcatgaactcttttggtttt	0													28	30					0	0	0	0	G	28541483	G	G	28541483	3	3	36	1	0	0	0	0	1	0	0	0	13941	913	32	2	1798	2	SCAND3	6	28541483	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	244185	28541483	142573584	348	7148											
OR2J3	442186	broad.mit.edu	37	chr6	29080281	29080281	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagctgaccctcatgatcaCaagctccatatttgttctca	10	13	6	12	0	3	3	3	3	1	0	5	3	4	3	2	0	2	3	2	0	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:29080281C>G	uc011dll.1	+	1	614	c.614C>G	c.(613-615)ACA>AGA	p.T205R		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTCATGATCACAAGCTCCATA	0.468													60	38					0	0	0	0	G	29080281	G	G	29080281	3	3	36	1	0	0	0	0	1	0	0	0	11058	478	17	4	616	4	OR2J3	6	29080281	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	538798	29080281	142034786	349	7149											
HLA-B	3106	broad.mit.edu	37	chr6	31324214	31324214	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtacatgctctggagggtgtGagaccctggccccggccccg	5	7	15	14	2	1	1	0	1	1	1	1	3	1	2	5	4	2	2	5	4	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:31324214G>C	uc003nth.2	-	3	403	c.349C>G	c.(349-351)CAC>GAC	p.H117D	HLA-C_uc003ntb.2_5'Flank|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_5'Flank|HLA-B_uc011dnk.1_5'Flank|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_5'UTR|HLA-B_uc003nti.1_5'Flank|HLA-B_uc010jsn.1_5'Flank|HLA-B_uc010jso.2_Missense_Mutation_p.H89D	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	117	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						TGGAGGGTGTGAGACCCTGGC	0.697									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				7	17					0	0	0	0	C	31324214	C	C	31324214	3	2	36	1	0	0	0	0	1	0	0	0	7235	1290	45	2	759	2	HLA-B	6	31324214	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2243933	31324214	139790853	350	7150											
HSPA1B	3304	broad.mit.edu	37	chr6	31797593	31797593	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtcccgggcctggcggcttCggggctcagggtcccaaggg	3	6	19	13	3	1	0	1	0	0	0	4	0	3	0	3	8	0	2	3	8	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:31797593C>T	uc003nxk.2	+	1	2082	c.1866C>T	c.(1864-1866)TTC>TTT	p.F622F		NM_005346	NP_005337	P08107	HSP71_HUMAN	heat shock 70kDa protein 1B	622					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			breast(1)	1						CTGGCGGCTTCGGGGCTCAGG	0.587													94	89					0	0	0	0	T	31797593	T	T	31797593	2	4	36	1	0	0	0	0	0	0	0	1	7448	883	31	1		1	HSPA1B	6	31797593	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	473379	31797593	139317474	351	7151											
SKIV2L	6499	broad.mit.edu	37	chr6	31933627	31933627	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcgtacagtagtgtttgactCcatgcgcaaacacgatggct	10	11	10	10	3	0	1	0	1	0	0	2	2	1	1	1	1	3	5	1	1	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:31933627C>G	uc003nyn.1	+	18	2428	c.2039C>G	c.(2038-2040)TCC>TGC	p.S680C	SKIV2L_uc011dou.1_Missense_Mutation_p.S522C|SKIV2L_uc011dov.1_Missense_Mutation_p.S487C	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	680	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						GTGTTTGACTCCATGCGCAAA	0.587													58	50					0	0	0	0	G	31933627	G	G	31933627	3	3	36	1	0	0	0	0	1	0	0	0	14424	855	30	2	2109	2	SKIV2L	6	31933627	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	136034	31933627	139181440	352	7152											
HLA-DOA	3111	broad.mit.edu	37	chr6	32975985	32975985	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaattcatgggtgaactggcCcgaggcgccgtaagactggt	10	8	14	9	3	1	2	1	1	0	1	1	3	1	2	2	4	1	1	2	4	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:32975985C>G	uc003ocr.2	-	2	212	c.136G>C	c.(136-138)GGC>CGC	p.G46R	HLA-DOA_uc010juj.2_Missense_Mutation_p.G16R|HLA-DOA_uc010jui.2_Missense_Mutation_p.G46R	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	46	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						GTGAACTGGCCCGAGGCGCCG	0.547													38	30					0	0	0	0	G	32975985	G	G	32975985	3	3	36	1	0	0	0	0	1	0	0	0	7239	623	22	4	632	4	HLA-DOA	6	32975985	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1042358	32975985	138139082	353	7153											
COL11A2	1302	broad.mit.edu	37	chr6	33135224	33135224	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgagcctgggagccccctCagaccatcagggccaggttt	8	7	12	14	0	2	2	2	1	0	1	2	3	2	3	5	3	2	1	5	3	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:33135224C>G	uc003ocx.1	-	56	4329	c.4101G>C	c.(4099-4101)CTG>CTC	p.L1367L	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Silent_p.L1281L|COL11A2_uc003ocz.1_Silent_p.L1260L	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1367	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GGAGCCCCCTCAGACCATCAG	0.667													30	32					0	0	0	0	G	33135224	G	G	33135224	2	3	36	1	0	0	0	0	0	0	0	1	3683	813	29	2		2	COL11A2	6	33135224	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	159239	33135224	137979843	354	7154											
B3GALT4	8705	broad.mit.edu	37	chr6	33245746	33245746	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtgtatgtcaacgtccctGaactggtatcagagctggtc	9	12	11	9	1	2	2	2	1	0	1	4	2	3	2	1	2	3	3	1	2	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:33245746G>C	uc003odr.2	+	1	830	c.550G>C	c.(550-552)GAA>CAA	p.E184Q		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	184	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						CAACGTCCCTGAACTGGTATC	0.587													93	82					0	0	0	0	C	33245746	C	C	33245746	3	2	36	1	0	0	0	0	1	0	0	0	1251	1291	45	2	552	2	B3GALT4	6	33245746	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	110522	33245746	137869321	355	7155											
ITPR3	3710	broad.mit.edu	37	chr6	33662853	33662853	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgcccagctcaacgagctCaaggagcaggtgtgcacccc	10	5	11	15	1	2	0	2	0	0	0	2	2	2	1	3	2	6	4	3	2	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:33662853C>G	uc011drk.1	+	57	8157	c.7938C>G	c.(7936-7938)CTC>CTG	p.L2646L	C6orf125_uc003oez.1_RNA	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2646	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TCAACGAGCTCAAGGAGCAGG	0.612													19	31					0	0	0	0	G	33662853	G	G	33662853	2	3	36	1	0	0	0	0	0	0	0	1	7961	813	29	2		2	ITPR3	6	33662853	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	417107	33662853	137452214	356	7156											
GRM4	2914	broad.mit.edu	37	chr6	33995958	33995958	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgttgggccggaagttgccCttctgcgtgaacttgttgga	5	12	14	10	3	1	1	0	1	1	0	1	3	1	3	3	3	3	3	3	3	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:33995958C>T	uc003oir.3	-	9	2798	c.2628G>A	c.(2626-2628)AAG>AAA	p.K876K	GRM4_uc011dsn.1_Silent_p.K829K|GRM4_uc010jvh.2_Silent_p.K876K|GRM4_uc010jvi.2_Silent_p.K568K|GRM4_uc003oio.2_Silent_p.K568K|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Silent_p.K736K|GRM4_uc003oiq.2_Silent_p.K743K|GRM4_uc011dsm.1_Silent_p.K707K	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	876	Cytoplasmic (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	GGAAGTTGCCCTTCTGCGTGA	0.637													31	27					0	0	0	0	T	33995958	T	T	33995958	2	4	36	1	0	0	0	0	0	0	0	1	6838	680	24	4		4	GRM4	6	33995958	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	333105	33995958	137119109	357	7157											
PACSIN1	29993	broad.mit.edu	37	chr6	34499414	34499414	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggccagccctacgccaccGagtggtcagacgacgagagt	10	4	14	13	4	1	2	1	0	0	2	1	6	1	2	4	2	2	0	4	2	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:34499414G>A	uc003ojo.2	+	9	1281	c.1075G>A	c.(1075-1077)GAG>AAG	p.E359K	PACSIN1_uc003ojp.2_Missense_Mutation_p.E359K	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	359					endocytosis		protein kinase activity				0						CTACGCCACCGAGTGGTCAGA	0.647													5	187					0	0	0	0	A	34499414	A	A	34499414	3	1	36	1	0	0	0	0	1	0	0	0	11428	1059	37	1	1105	1	PACSIN1	6	34499414	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	503456	34499414	136615653	358	7158											
KIF6	221458	broad.mit.edu	37	chr6	39554121	39554121	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtctcttaggacactggtCatcatggagtttctataagg	9	14	10	8	0	4	0	2	0	2	0	5	2	4	2	0	4	0	1	0	4	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:39554121C>G	uc003oot.2	-	8	1001	c.906G>C	c.(904-906)ATG>ATC	p.M302I	KIF6_uc010jxa.1_Missense_Mutation_p.M93I|KIF6_uc011dua.1_Missense_Mutation_p.M302I|KIF6_uc010jxb.1_Missense_Mutation_p.M302I	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	302					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						GGACACTGGTCATCATGGAGT	0.413													4	194					0	0	0	0	G	39554121	G	G	39554121	3	3	36	1	0	0	0	0	1	0	0	0	8347	826	29	2	1602	2	KIF6	6	39554121	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5054707	39554121	131560946	359	7159											
USP49	25862	broad.mit.edu	37	chr6	41767599	41767599	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtgcagccggagaacctGaggtagtctgtagatcatta	12	9	13	7	1	2	3	1	1	1	2	2	4	2	3	2	3	3	3	2	3	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:41767599G>A	uc003ori.2	-	6	1861	c.1639C>T	c.(1639-1641)CAG>TAG	p.Q547*		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	547					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CGGAGAACCTGAGGTAGTCTG	0.488													6	425					0	0	0	0	A	41767599	A	A	41767599	4	1	36	1	0	0	0	0	0	1	0	0	17148	1299	45	2	291	2	USP49	6	41767599	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2213478	41767599	129347468	360	7160											
UBR2	23304	broad.mit.edu	37	chr6	42626426	42626426	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgagaggaagagaaaagcaGagattgccagactgcgcaga	16	4	14	7	1	0	5	0	1	0	5	0	9	0	6	1	1	3	2	1	1	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:42626426G>C	uc011dur.1	+	29	3106	c.3106G>C	c.(3106-3108)GAG>CAG	p.E1036Q	UBR2_uc011dus.1_Missense_Mutation_p.E681Q|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1036	Potential.				cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GAGAAAAGCAGAGATTGCCAG	0.388													37	83					0	0	0	0	C	42626426	C	C	42626426	3	2	36	1	0	0	0	0	1	0	0	0	16970	943	33	2	3366	2	UBR2	6	42626426	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	858827	42626426	128488641	361	7161											
UBR2	23304	broad.mit.edu	37	chr6	42626464	42626464	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagaaaagatcatggctcaGatgtctgaaatgcagcggca	15	7	12	7	1	3	4	2	1	1	3	3	5	3	4	0	2	2	3	0	2	3	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:42626464G>C	uc011dur.1	+	29	3144	c.3144G>C	c.(3142-3144)CAG>CAC	p.Q1048H	UBR2_uc011dus.1_Missense_Mutation_p.Q693H|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1048	Potential.				cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			TCATGGCTCAGATGTCTGAAA	0.423													61	102					0	0	0	0	C	42626464	C	C	42626464	3	2	36	1	0	0	0	0	1	0	0	0	16970	933	33	2	3404	2	UBR2	6	42626464	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	38	42626464	128488603	362	7162											
CUL7	9820	broad.mit.edu	37	chr6	43015985	43015985	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaagtccaccagctgcttCaggattctgggggcagagaa	10	7	15	9	0	2	1	1	0	1	1	3	4	3	3	2	4	2	3	2	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:43015985C>T	uc003otq.2	-	9	2373	c.2070G>A	c.(2068-2070)CTG>CTA	p.L690L	CUL7_uc010jyg.2_5'Flank|CUL7_uc011dvb.1_Silent_p.L774L|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	690					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCAGCTGCTTCAGGATTCTGG	0.617													47	187					0	0	0	0	T	43015985	T	T	43015985	2	4	36	1	0	0	0	0	0	0	0	1	4077	813	29	2		2	CUL7	6	43015985	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	389521	43015985	128099082	363	7163											
SLC22A7	10864	broad.mit.edu	37	chr6	43266316	43266316	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatcttccccgggagcctGatggcacgctcagctcctgc	5	8	10	18	2	2	1	1	1	1	0	4	2	4	2	5	2	3	3	5	2	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:43266316G>T	uc003out.2	+	1	319	c.220G>T	c.(220-222)GAT>TAT	p.D74Y	SLC22A7_uc010jyl.1_Missense_Mutation_p.D74Y|SLC22A7_uc003ous.2_Missense_Mutation_p.D74Y	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	74						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CCGGGAGCCTGATGGCACGCT	0.662													34	64					1.26612e-14	1.33367e-14	1	0	T	43266316	T	T	43266316	3	4	36	1	0	0	0	0	1	0	0	0	14523	1290	45	2	222	2	SLC22A7	6	43266316	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	250331	43266316	127848751	364	7164											
SPATS1	221409	broad.mit.edu	37	chr6	44329585	44329585	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaagatgggcatcgtcctGagtggacattttacccaagg	11	9	12	9	1	0	3	0	1	0	2	2	4	1	4	2	3	1	1	2	3	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:44329585G>A	uc003oxk.2	+	4	777	c.430G>A	c.(430-432)GAG>AAG	p.E144K	SPATS1_uc003oxg.2_RNA|SPATS1_uc010jzb.2_Missense_Mutation_p.E29K	NM_145026	NP_659463	Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	144										skin(1)	1	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GCATCGTCCTGAGTGGACATT	0.473													43	175					0	0	0	0	A	44329585	A	A	44329585	3	1	36	1	0	0	0	0	1	0	0	0	15084	1291	45	2	444	2	SPATS1	6	44329585	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1063269	44329585	126785482	365	7165											
TDRD6	221400	broad.mit.edu	37	chr6	46657053	46657053	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggtcacaggtcggtgacctGaagacactgatactaggcaa	12	7	12	10	2	1	4	1	3	0	1	2	4	1	4	1	4	1	1	1	4	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:46657053G>A	uc003oyj.2	+	1	1188	c.1188G>A	c.(1186-1188)CTG>CTA	p.L396L	TDRD6_uc010jze.2_Silent_p.L390L	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	396					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TCGGTGACCTGAAGACACTGA	0.478													66	107					0	0	0	0	A	46657053	A	A	46657053	2	1	36	1	0	0	0	0	0	0	0	1	15800	1277	45	2		2	TDRD6	6	46657053	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2327468	46657053	124458014	366	7166											
TFAP2B	7021	broad.mit.edu	37	chr6	50807940	50807940	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcccgccaaagccgtctctGagtatttgaaccggcagcac	9	9	9	14	3	1	2	0	2	1	0	3	2	2	2	4	1	3	3	4	1	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:50807940G>C	uc003pag.2	+	6	1178	c.1012G>C	c.(1012-1014)GAG>CAG	p.E338Q		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	338					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					AGCCGTCTCTGAGTATTTGAA	0.478													98	174					0	0	0	0	C	50807940	C	C	50807940	3	2	36	1	0	0	0	0	1	0	0	0	15854	1291	45	2	1034	2	TFAP2B	6	50807940	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4150887	50807940	120307127	367	7167											
PKHD1	5314	broad.mit.edu	37	chr6	51938280	51938280	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctatcaatgtactcagcatCaaaatcaaaagtttccaatc	16	11	3	11	0	4	0	4	0	0	0	6	0	5	0	2	0	2	3	2	0	8	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:51938280C>T	uc003pah.1	-	7	784	c.508G>A	c.(508-510)GAT>AAT	p.D170N	PKHD1_uc003pai.2_Missense_Mutation_p.D170N	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	170	IPT/TIG 2.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TACTCAGCATCAAAATCAAAA	0.358													83	144					0	0	0	0	T	51938280	T	T	51938280	3	4	36	1	0	0	0	0	1	0	0	0	12026	826	29	2	11999	2	PKHD1	6	51938280	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1130340	51938280	119176787	368	7168											
MCM3	4172	broad.mit.edu	37	chr6	52133882	52133882	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccaggcatctgaatcctcAccttcttaaagtaagcatac	12	10	6	13	0	3	1	1	1	2	0	4	1	4	1	3	1	2	3	3	1	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:52133882A>G	uc003pan.1	-	13	2078	c.1968_splice	c.e13+1	p.K656_splice	MCM3_uc011dwu.1_Splice_Site_p.K610_splice	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3						cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					CTGAATCCTCACCTTCTTAAA	0.532													62	140					0	0	0	0	G	52133882	G	G	52133882	5	3	36	1	0	0	0	0	0	0	1	0	9440	173	6	5	476	5	MCM3	6	52133882	Splice_Site	SNP	A	TCGA-CN-4723-01A-01D-1434-08	195602	52133882	118981185	369	7169											
BMP5	653	broad.mit.edu	37	chr6	55638959	55638959	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaagtacctcactcgccttGaagaaggccaccatgaatgg	13	7	10	11	1	1	4	1	2	0	2	2	4	1	4	4	2	1	1	4	2	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:55638959G>C	uc003pcq.2	-	4	1627	c.915C>G	c.(913-915)TTC>TTG	p.F305L	BMP5_uc011dxf.1_Missense_Mutation_p.F305L	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	305					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			CACTCGCCTTGAAGAAGGCCA	0.453													126	221					0	0	0	0	C	55638959	C	C	55638959	3	2	36	1	0	0	0	0	1	0	0	0	1466	1281	45	2	465	2	BMP5	6	55638959	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3505077	55638959	115476108	370	7170											
COL12A1	1303	broad.mit.edu	37	chr6	75833986	75833986	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cataccatctgcagggcttaGttttagcctgtaggaggtgg	8	12	13	8	0	1	0	0	0	1	0	1	1	1	1	2	4	3	4	2	4	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:75833986G>C	uc003phs.2	-	41	6875	c.6709C>G	c.(6709-6711)CTA>GTA	p.L2237V	COL12A1_uc003pht.2_Missense_Mutation_p.L1073V	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2237	Fibronectin type-III 18.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GCAGGGCTTAGTTTTAGCCTG	0.378													4	116					0	0	0	0	C	75833986	C	C	75833986	3	2	36	1	0	0	0	0	1	0	0	0	3684	1020	36	4	2586	4	COL12A1	6	75833986	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	20195027	75833986	95281081	371	7171											
LCA5	167691	broad.mit.edu	37	chr6	80196747	80196747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtgctacttcttcaatttCatcttctacagaatcagctg	10	15	5	11	0	6	1	3	0	3	1	6	1	6	1	0	0	4	2	0	0	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:80196747C>T	uc003pix.2	-	8	2503	c.2068G>A	c.(2068-2070)GAA>AAA	p.E690K	LCA5_uc003piy.2_Missense_Mutation_p.E690K	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	690					protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TCTTCAATTTCATCTTCTACA	0.303													53	59					0	0	0	0	T	80196747	T	T	80196747	3	4	36	1	0	0	0	0	1	0	0	0	8696	835	29	2	29	2	LCA5	6	80196747	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4362761	80196747	90918320	372	7172											
DOPEY1	23033	broad.mit.edu	37	chr6	83848789	83848789	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacatgggaaaagttctgcaGagagtggttgtttctgtgac	10	13	13	5	0	2	2	0	1	2	1	2	4	2	3	0	2	2	4	0	2	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:83848789G>C	uc003pjs.1	+	21	5288	c.5028G>C	c.(5026-5028)CAG>CAC	p.Q1676H	DOPEY1_uc011dyy.1_Missense_Mutation_p.Q1667H|DOPEY1_uc010kbl.1_Missense_Mutation_p.Q1667H|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1676					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAGTTCTGCAGAGAGTGGTTG	0.403													3	124					0	0	0	0	C	83848789	C	C	83848789	3	2	36	1	0	0	0	0	1	0	0	0	4729	933	33	2	5102	2	DOPEY1	6	83848789	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3652042	83848789	87266278	373	7173											
GPR63	81491	broad.mit.edu	37	chr6	97246864	97246864	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagggtatgaagaaagaaatGagagaaatcaaaatcacata	23	6	9	3	0	2	5	2	2	0	3	2	6	2	5	0	1	0	1	0	1	9	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:97246864G>C	uc010kcl.2	-	3	1222	c.744C>G	c.(742-744)CTC>CTG	p.L248L	GPR63_uc003pou.2_Silent_p.L248L	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	248	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AGAAAGAAATGAGAGAAATCA	0.473													72	81					0	0	0	0	C	97246864	C	C	97246864	2	2	36	1	0	0	0	0	0	0	0	1	6742	1277	45	2		2	GPR63	6	97246864	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	13398075	97246864	73868203	374	7174											
POU3F2	5454	broad.mit.edu	37	chr6	99282855	99282855	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcgcggggggctaccgcGaagcgcagagcctggtgcag	7	3	20	11	5	0	1	0	0	0	1	0	2	0	1	2	5	4	3	2	5	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:99282855G>T	uc003ppe.2	+	1	276	c.106G>T	c.(106-108)GAA>TAA	p.E36*		NM_005604	NP_005595	P20265	PO3F2_HUMAN	POU domain, class 3, transcription factor 2	36					positive regulation of cell proliferation		identical protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0355)		GGGCTACCGCGAAGCGCAGAG	0.682													7	24					4.93089e-13	5.17617e-13	1	0	T	99282855	T	T	99282855	4	4	36	1	0	0	0	0	0	1	0	0	12330	1059	37	3	108	3	POU3F2	6	99282855	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2035991	99282855	71832212	375	7175											
LAMA4	3910	broad.mit.edu	37	chr6	112508744	112508744	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccccggatttgccttcctCgatggagagcgctgctaacc	7	9	10	15	3	0	1	0	0	0	1	2	4	1	2	5	2	4	2	5	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:112508744C>T	uc003pvu.2	-	8	1183	c.874G>A	c.(874-876)GAG>AAG	p.E292K	LAMA4_uc003pvv.2_Missense_Mutation_p.E285K|LAMA4_uc003pvt.2_Missense_Mutation_p.E285K	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	292	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTGCCTTCCTCGATGGAGAGC	0.537													10	35					0	0	0	0	T	112508744	T	T	112508744	3	4	36	1	0	0	0	0	1	0	0	0	8648	893	31	1	4725	1	LAMA4	6	112508744	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	13225889	112508744	58606323	376	7176											
COL10A1	1300	broad.mit.edu	37	chr6	116442593	116442593	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cacctttgatgcctggctgtCctggaaccccattttcacct	6	13	7	15	0	1	1	1	1	0	0	2	2	2	2	6	2	2	1	6	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:116442593C>G	uc003pwm.2	-	3	782	c.686G>C	c.(685-687)GGA>GCA	p.G229A	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	229	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		GCCTGGCTGTCCTGGAACCCC	0.607													24	111					0	0	0	0	G	116442593	G	G	116442593	3	3	36	1	0	0	0	0	1	0	0	0	3681	855	30	2	1360	2	COL10A1	6	116442593	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3933849	116442593	54672474	377	7177											
RFX6	222546	broad.mit.edu	37	chr6	117232167	117232167	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccagaattccccagcgctCaacaccttgtataccaagga	12	9	6	14	1	1	1	1	0	0	1	3	2	3	2	5	1	3	2	5	1	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:117232167C>T	uc003pxm.2	+	7	805	c.742C>T	c.(742-744)CAA>TAA	p.Q248*		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	248					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						CCCCAGCGCTCAACACCTTGT	0.363													40	169					0	0	0	0	T	117232167	T	T	117232167	4	4	36	1	0	0	0	0	0	1	0	0	13332	827	29	2	768	2	RFX6	6	117232167	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	789574	117232167	53882900	378	7178											
FAM184A	79632	broad.mit.edu	37	chr6	119345573	119345573	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgtgagcagcttgcaagtCttccaatgccaatcgtttgt	8	14	9	10	1	2	1	0	1	2	0	4	1	3	1	2	0	4	4	2	0	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:119345573C>G	uc003pyj.2	-	2	913	c.565G>C	c.(565-567)GAC>CAC	p.D189H	FAM184A_uc003pyk.3_Missense_Mutation_p.D69H|FAM184A_uc003pyl.3_Missense_Mutation_p.D69H	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	189	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						GCTTGCAAGTCTTCCAATGCC	0.418													46	198					0	0	0	0	G	119345573	G	G	119345573	3	3	36	1	0	0	0	0	1	0	0	0	5539	913	32	2	2925	2	FAM184A	6	119345573	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2113406	119345573	51769494	379	7179											
SMPDL3A	10924	broad.mit.edu	37	chr6	123126144	123126144	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actataatgagaaattgataGatatttttcaaaaatacagt	19	14	5	3	0	1	3	1	2	0	2	1	4	1	3	0	0	1	0	0	0	8	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:123126144G>C	uc003pzg.2	+	6	1350	c.829G>C	c.(829-831)GAT>CAT	p.D277H	SMPDL3A_uc003pzh.2_Missense_Mutation_p.D146H	NM_006714	NP_006705	Q92484	ASM3A_HUMAN	acid sphingomyelinase-like phosphodiesterase 3A	277					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|protein binding|sphingomyelin phosphodiesterase activity				0				GBM - Glioblastoma multiforme(226;0.236)		GAAATTGATAGATATTTTTCA	0.348													7	227					0	0	0	0	C	123126144	C	C	123126144	3	2	36	1	0	0	0	0	1	0	0	0	14872	942	33	2	851	2	SMPDL3A	6	123126144	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3780571	123126144	47988923	380	7180											
ARHGAP18	93663	broad.mit.edu	37	chr6	129959708	129959708	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caatgctttcctgtggatctCcagcagactctccgaagaga	10	10	9	12	1	2	2	0	0	2	2	5	5	3	3	3	1	2	2	3	1	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:129959708C>G	uc003qbr.2	-	3	472	c.383G>C	c.(382-384)GGA>GCA	p.G128A	ARHGAP18_uc011ebw.1_Missense_Mutation_p.G128A	NM_033515	NP_277050	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	128					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			ovary(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		CTGTGGATCTCCAGCAGACTC	0.473													48	102					0	0	0	0	G	129959708	G	G	129959708	3	3	36	1	0	0	0	0	1	0	0	0	868	855	30	2	1660	2	ARHGAP18	6	129959708	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6833564	129959708	41155359	381	7181											
L3MBTL3	84456	broad.mit.edu	37	chr6	130425591	130425591	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctgccaactgtccctattCagaaatcaatttgaataaag	14	12	6	9	0	2	2	2	1	0	1	3	2	3	2	2	0	3	1	2	0	7	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:130425591C>G	uc003qbt.2	+	19	1927	c.1757C>G	c.(1756-1758)TCA>TGA	p.S586*	L3MBTL3_uc003qbu.2_Nonsense_Mutation_p.S561*	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	586					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		TGTCCCTATTCAGAAATCAAT	0.368													78	158					0	0	0	0	G	130425591	G	G	130425591	4	3	36	1	0	0	0	0	0	1	0	0	8633	838	29	2	1823	2	L3MBTL3	6	130425591	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	465883	130425591	40689476	382	7182											
MED23	9439	broad.mit.edu	37	chr6	131931197	131931197	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtacataccttctgatgaaGagaaagcaccatatgtggaa	16	9	9	7	0	1	3	0	2	1	1	1	5	1	4	2	1	3	2	2	1	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:131931197G>A	uc003qcs.1	-	11	1240	c.1066C>T	c.(1066-1068)CTT>TTT	p.L356F	MED23_uc003qcq.2_Missense_Mutation_p.L362F|MED23_uc011eca.1_Missense_Mutation_p.L45F|MED23_uc003qct.1_Missense_Mutation_p.L362F|MED23_uc011ecb.1_RNA	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	356					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		TTCTGATGAAGAGAAAGCACC	0.428													30	79					0	0	0	0	A	131931197	A	A	131931197	3	1	36	1	0	0	0	0	1	0	0	0	9494	942	33	2	3123	2	MED23	6	131931197	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1505606	131931197	39183870	383	7183											
MAP3K5	4217	broad.mit.edu	37	chr6	136960771	136960771	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcatctttcttcaaatttaGaaatactgaaaccaacaaac	18	11	3	9	0	3	2	1	1	2	1	3	2	3	2	1	0	5	1	1	0	7	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:136960771G>C	uc003qhc.2	-	13	2205	c.1844C>G	c.(1843-1845)TCT>TGT	p.S615C	MAP3K5_uc011edj.1_5'UTR|MAP3K5_uc011edk.1_Missense_Mutation_p.S460C	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	615					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TTCAAATTTAGAAATACTGAA	0.289													13	37					0	0	0	0	C	136960771	C	C	136960771	3	2	36	1	0	0	0	0	1	0	0	0	9306	942	33	2	2352	2	MAP3K5	6	136960771	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5029574	136960771	34154296	384	7184											
IFNGR1	3459	broad.mit.edu	37	chr6	137525504	137525504	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctcacatacacattgtacaCcctaatgtaacaggtagttt	13	13	5	10	0	1	0	1	0	1	0	2	0	1	0	1	1	3	4	1	1	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:137525504C>T	uc003qho.2	-	4	614	c.511G>A	c.(511-513)GTG>ATG	p.V171M	IFNGR1_uc011edm.1_Missense_Mutation_p.V143M|IFNGR1_uc011edn.1_Missense_Mutation_p.V161M	NM_000416	NP_000407	P15260	INGR1_HUMAN	interferon gamma receptor 1 precursor	171	Extracellular (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	ACATTGTACACCCTAATGTAA	0.378													49	191					0	0	0	0	T	137525504	T	T	137525504	3	4	36	1	0	0	0	0	1	0	0	0	7588	507	18	4	974	4	IFNGR1	6	137525504	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	564733	137525504	33589563	385	7185											
UTRN	7402	broad.mit.edu	37	chr6	144808819	144808819	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttcaacagccgatatgaaGatctaagtcacctggtaaga	14	10	8	9	1	3	3	2	1	1	2	3	4	3	3	2	1	2	1	2	1	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:144808819G>C	uc003qkt.2	+	28	4050	c.3958G>C	c.(3958-3960)GAT>CAT	p.D1320H		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1320	Spectrin 9.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CCGATATGAAGATCTAAGTCA	0.458													34	92					0	0	0	0	C	144808819	C	C	144808819	3	2	36	1	0	0	0	0	1	0	0	0	17171	942	33	2	4068	2	UTRN	6	144808819	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	7283315	144808819	26306248	386	7186											
GRM1	2911	broad.mit.edu	37	chr6	146673564	146673564	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagctgctggacttcctcatCaagtcctcattcattggagt	9	13	8	11	0	4	0	4	0	0	0	6	2	6	2	2	2	2	2	2	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:146673564C>T	uc010khw.1	+	5	1835	c.1365C>T	c.(1363-1365)ATC>ATT	p.I455I	GRM1_uc010khv.1_Silent_p.I455I|GRM1_uc003qll.2_Silent_p.I455I|GRM1_uc011edz.1_Silent_p.I455I|GRM1_uc011eea.1_Silent_p.I455I	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	455	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ACTTCCTCATCAAGTCCTCAT	0.522													70	283					0	0	0	0	T	146673564	T	T	146673564	2	4	36	1	0	0	0	0	0	0	0	1	6835	816	29	2		2	GRM1	6	146673564	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1864745	146673564	24441503	387	7187											
SYNE1	23345	broad.mit.edu	37	chr6	152686067	152686067	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaatagtgggaatgccttCtggagaagtattctgaagga	12	11	13	5	0	2	3	0	2	2	1	2	6	2	5	1	3	1	1	1	3	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:152686067C>G	uc010kiw.2	-	63	10662	c.10060G>C	c.(10060-10062)GAA>CAA	p.E3354Q	SYNE1_uc003qot.3_Missense_Mutation_p.E3361Q|SYNE1_uc003qou.3_Missense_Mutation_p.E3354Q|SYNE1_uc010kja.1_Missense_Mutation_p.E59Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3354	Spectrin 7.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGAATGCCTTCTGGAGAAGTA	0.438										HNSCC(10;0.0054)			36	123					0	0	0	0	G	152686067	G	G	152686067	3	3	36	1	0	0	0	0	1	0	0	0	15511	922	32	2	16742	2	SYNE1	6	152686067	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6012503	152686067	18429000	388	7188											
SYNE1	23345	broad.mit.edu	37	chr6	152686096	152686096	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tattctgaaggacagattctCccctggtcactatcattttc	9	15	6	11	0	4	2	2	1	2	1	6	3	4	3	2	2	0	0	2	2	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:152686096C>G	uc010kiw.2	-	63	10633	c.10031G>C	c.(10030-10032)GGA>GCA	p.G3344A	SYNE1_uc003qot.3_Missense_Mutation_p.G3351A|SYNE1_uc003qou.3_Missense_Mutation_p.G3344A|SYNE1_uc010kja.1_Missense_Mutation_p.G49A	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3344	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACAGATTCTCCCCTGGTCAC	0.428										HNSCC(10;0.0054)			36	110					0	0	0	0	G	152686096	G	G	152686096	3	3	36	1	0	0	0	0	1	0	0	0	15511	855	30	2	16771	2	SYNE1	6	152686096	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	29	152686096	18428971	389	7189											
FNDC1	84624	broad.mit.edu	37	chr6	159654085	159654085	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctcggctgcagccctccagCtccccacagtcgactgtgcc	5	7	9	20	2	0	0	0	0	0	0	4	1	2	0	6	1	4	3	6	1	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:159654085C>T	uc010kjv.2	+	11	2741	c.2541C>T	c.(2539-2541)AGC>AGT	p.S847S	FNDC1_uc010kjw.1_Silent_p.S732S	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	847						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGCCCTCCAGCTCCCCACAGT	0.607													7	16					0	0	0	0	T	159654085	T	T	159654085	2	4	36	1	0	0	0	0	0	0	0	1	6000	796	28	4		4	FNDC1	6	159654085	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6967989	159654085	11460982	390	7190											
LPA	4018	broad.mit.edu	37	chr6	160977188	160977188	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccattaccatggtagcactgCcggaccacaggggtttgctc	8	9	11	13	1	0	0	0	0	0	0	1	1	0	1	4	4	4	4	4	4	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:160977188C>T	uc003qtl.2	-	31	4962	c.4842G>A	c.(4840-4842)CGG>CGA	p.R1614R		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4122	Kringle 37.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity	p.R1614Q(1)		ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GGTAGCACTGCCGGACCACAG	0.468													4	161					0	0	0	0	T	160977188	T	T	160977188	2	4	36	1	0	0	0	0	0	0	0	1	8953	726	26	4		4	LPA	6	160977188	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1323103	160977188	10137879	391	7191											
PLG	5340	broad.mit.edu	37	chr6	161157959	161157959	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggaagcctcaagtggagccGaagaaatgtcctggaagggt	12	6	16	7	1	1	1	1	0	0	1	2	5	2	4	3	4	2	0	3	4	5	0	rs146030266		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:161157959G>A	uc003qtm.3	+	14	1785	c.1722G>A	c.(1720-1722)CCG>CCA	p.P574P		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	574					extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AAGTGGAGCCGAAGAAATGTC	0.517													42	85					0	0	0	0	A	161157959	A	A	161157959	2	1	36	1	0	0	0	0	0	0	0	1	12141	1045	37	1		1	PLG	6	161157959	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	180771	161157959	9957108	392	7192											
MAP3K4	4216	broad.mit.edu	37	chr6	161470020	161470020	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctaaagcttacctcagtctCaaagaaaaaagacagggagc	17	6	9	9	0	2	2	2	0	1	2	3	3	2	3	1	1	3	2	1	1	7	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:161470020C>G	uc003qtn.2	+	3	858	c.716C>G	c.(715-717)TCA>TGA	p.S239*	MAP3K4_uc010kkc.1_Nonsense_Mutation_p.S239*|MAP3K4_uc003qto.2_Nonsense_Mutation_p.S239*|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	239					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		ACCTCAGTCTCAAAGAAAAAA	0.433													21	70					0	0	0	0	G	161470020	G	G	161470020	4	3	36	1	0	0	0	0	0	1	0	0	9305	838	29	2	726	2	MAP3K4	6	161470020	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	312061	161470020	9645047	393	7193											
C6orf118	168090	broad.mit.edu	37	chr6	165693562	165693562	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcgttatcttctgtttcctCtgattttacaaattccttga	8	19	5	9	1	3	2	0	2	3	0	5	2	5	2	2	0	2	2	2	0	3	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:165693562C>G	uc003qum.3	-	9	1430	c.1394G>C	c.(1393-1395)AGA>ACA	p.R465T		NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	465											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TCTGTTTCCTCTGATTTTACA	0.323													27	63					0	0	0	0	G	165693562	G	G	165693562	3	3	36	1	0	0	0	0	1	0	0	0	2333	913	32	2	19	2	C6orf118	6	165693562	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4223542	165693562	5421505	394	7194											
RPS6KA2	6196	broad.mit.edu	37	chr6	166918077	166918077	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctcagccaggtagaacttGacatcctcctccgtgaacat	11	9	8	13	1	1	3	1	2	0	1	4	3	4	3	4	1	4	2	4	1	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:166918077G>A	uc003qvb.1	-	6	702	c.483C>T	c.(481-483)GTC>GTT	p.V161V	RPS6KA2_uc011ego.1_Silent_p.V72V|RPS6KA2_uc010kkl.1_Silent_p.V72V|RPS6KA2_uc003qvc.1_Silent_p.V169V|RPS6KA2_uc003qvd.1_Silent_p.V186V	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	161	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GGTAGAACTTGACATCCTCCT	0.398													52	119					0	0	0	0	A	166918077	A	A	166918077	2	1	36	1	0	0	0	0	0	0	0	1	13716	1277	45	2		2	RPS6KA2	6	166918077	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1224515	166918077	4196990	395	7195											
TCP10	6953	broad.mit.edu	37	chr6	167787923	167787923	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgccttcagaactccctaaGactgatgagcttctgtctaa	10	11	7	13	1	3	4	1	2	2	2	4	4	4	4	3	0	2	1	3	0	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr6:167787923G>C	uc003qvv.1	-	7	917	c.705C>G	c.(703-705)GTC>GTG	p.V235V	TCP10_uc003qvu.2_Silent_p.V235V|TCP10_uc003qvw.2_3'UTR	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10	262						cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		AACTCCCTAAGACTGATGAGC	0.463													3	44					0	0	0	0	C	167787923	C	C	167787923	2	2	36	1	0	0	0	0	0	0	0	1	15776	929	33	2		2	TCP10	6	167787923	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	869846	167787923	3327144	396	7196											
HEATR2	54919	broad.mit.edu	37	chr7	794332	794332	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggtggtggggacccgagtGaagtcggcacagctgctccc	6	7	17	11	2	0	1	0	1	0	0	2	3	1	2	2	5	2	3	2	5	1	0	rs151119269		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:794332G>A	uc010krz.1	+	5	1151	c.1131G>A	c.(1129-1131)GTG>GTA	p.V377V	HEATR2_uc003siz.2_Silent_p.V245V	NM_017802	NP_060272	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	377	HEAT 6.						protein binding			skin(1)	1		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		GGACCCGAGTGAAGTCGGCAC	0.672													68	174					0	0	0	0	A	794332	A	A	794332	2	1	36	1	0	0	0	0	0	0	0	1	7067	1277	45	2		2	HEATR2	7	794332	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08		794332	158344331	397	7197											
SUN1	23353	broad.mit.edu	37	chr7	912962	912962	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagttcatggcgaacctgtCaagtgaagacactactcatt	13	10	9	9	1	3	3	3	1	0	2	3	4	3	3	1	1	2	1	1	1	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:912962C>G	uc011jvp.1	+	20	2431	c.2352C>G	c.(2350-2352)GTC>GTG	p.V784V	GET4_uc003sjj.1_Intron|SUN1_uc003sjf.2_Silent_p.V701V|SUN1_uc011jvq.1_Silent_p.V681V|SUN1_uc003sjg.2_Silent_p.V689V|SUN1_uc011jvr.1_Silent_p.V582V|SUN1_uc003sji.2_Silent_p.V622V|SUN1_uc003sjk.2_Silent_p.V423V	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	811	Perinuclear space.|SUN.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GCGAACCTGTCAAGTGAAGAC	0.428											OREG0017816	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	158					0	0	0	0	G	912962	G	G	912962	2	3	36	1	0	0	0	0	0	0	0	1	15457	813	29	2		2	SUN1	7	912962	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	118630	912962	158225701	398	7198											
MICALL2	79778	broad.mit.edu	37	chr7	1486399	1486399	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggccaggtgccgctgtacCaggtgcacgtgcttgccgca	5	8	14	14	4	0	0	0	0	0	0	1	0	0	0	4	3	5	5	4	3	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:1486399C>G	uc003skj.3	-	5	738	c.591G>C	c.(589-591)CTG>CTC	p.L197L		NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	197	LIM zinc-binding.					cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GCCGCTGTACCAGGTGCACGT	0.677													3	24					0	0	0	0	G	1486399	G	G	1486399	2	3	36	1	0	0	0	0	0	0	0	1	9627	581	21	4		4	MICALL2	7	1486399	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	573437	1486399	157652264	399	7199											
SLC29A4	222962	broad.mit.edu	37	chr7	5340094	5340094	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gactggcggggcacccacctGctggcctgctcctgcctgcg	3	7	14	17	2	0	0	0	0	0	0	1	1	1	0	5	4	4	3	5	4	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:5340094G>C	uc003sod.2	+	10	1412	c.1251G>C	c.(1249-1251)CTG>CTC	p.L417L	SLC29A4_uc003soc.2_Silent_p.L417L|SLC29A4_uc003soe.2_Silent_p.L403L|SLC29A4_uc010ksw.2_Intron	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	417	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		GCACCCACCTGCTGGCCTGCT	0.706													28	68					0	0	0	0	C	5340094	C	C	5340094	2	2	36	1	0	0	0	0	0	0	0	1	14601	1306	46	4		4	SLC29A4	7	5340094	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3853695	5340094	153798569	400	7200											
RNF216	54476	broad.mit.edu	37	chr7	5662575	5662575	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgggaccgaagtcatagttGacccgcacgttgggcagagg	10	7	15	9	3	1	2	1	1	0	1	1	4	1	3	2	3	0	4	2	3	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:5662575G>A	uc003soy.1	-	17	2707	c.2517C>T	c.(2515-2517)GTC>GTT	p.V839V	RNF216_uc010ksz.1_Silent_p.V461V|RNF216_uc010kta.1_Silent_p.V461V|RNF216_uc011jwj.1_Silent_p.V461V|RNF216_uc003sox.1_Silent_p.V896V	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	839	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		AGTCATAGTTGACCCGCACGT	0.642													75	203					0	0	0	0	A	5662575	A	A	5662575	2	1	36	1	0	0	0	0	0	0	0	1	13545	1277	45	2		2	RNF216	7	5662575	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	322481	5662575	153476088	401	7201											
RNF216	54476	broad.mit.edu	37	chr7	5662592	5662592	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgacccgcacgttgggcaGagggggcacgtacggggctg	6	6	19	10	4	0	2	0	1	0	1	0	2	0	2	1	5	1	7	1	5	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:5662592G>C	uc003soy.1	-	17	2690	c.2500C>G	c.(2500-2502)CTG>GTG	p.L834V	RNF216_uc010ksz.1_Missense_Mutation_p.L456V|RNF216_uc010kta.1_Missense_Mutation_p.L456V|RNF216_uc011jwj.1_Missense_Mutation_p.L456V|RNF216_uc003sox.1_Missense_Mutation_p.L891V	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	834	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		ACGTTGGGCAGAGGGGGCACG	0.647													69	186					0	0	0	0	C	5662592	C	C	5662592	3	2	36	1	0	0	0	0	1	0	0	0	13545	933	33	2	104	2	RNF216	7	5662592	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	17	5662592	153476071	402	7202											
HDAC9	9734	broad.mit.edu	37	chr7	18624936	18624936	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagaagttcctgtgggcctgGagcccatctcacctttagac	8	10	10	13	0	1	2	1	0	1	2	3	3	2	3	4	2	1	1	4	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:18624936G>T	uc003suh.2	+	2	96	c.55G>T	c.(55-57)GAG>TAG	p.E19*	HDAC9_uc003sue.2_Nonsense_Mutation_p.E19*|HDAC9_uc011jyd.1_Nonsense_Mutation_p.E19*|HDAC9_uc003sui.2_Nonsense_Mutation_p.E19*|HDAC9_uc003suj.2_Nonsense_Mutation_p.E19*|HDAC9_uc011jya.1_Nonsense_Mutation_p.E60*|HDAC9_uc003sua.1_Nonsense_Mutation_p.E38*|HDAC9_uc011jyb.1_Nonsense_Mutation_p.E19*|HDAC9_uc003sud.1_Nonsense_Mutation_p.E19*|HDAC9_uc011jyc.1_Nonsense_Mutation_p.E19*|HDAC9_uc003suf.1_Nonsense_Mutation_p.E47*|HDAC9_uc010kud.1_Nonsense_Mutation_p.E19*|HDAC9_uc011jye.1_5'UTR|HDAC9_uc011jyf.1_5'UTR	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	19					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TGTGGGCCTGGAGCCCATCTC	0.483													95	245					3.17824e-57	3.45179e-57	1	0	T	18624936	T	T	18624936	4	4	36	1	0	0	0	0	0	1	0	0	7053	1175	41	2	61	2	HDAC9	7	18624936	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	12962344	18624936	140513727	403	7203											
CDCA7L	55536	broad.mit.edu	37	chr7	21947813	21947813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctgaactctcctggctctCatcccgagagtcatcctcag	8	11	7	15	1	5	2	3	1	3	1	9	3	7	2	3	1	1	1	3	1	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:21947813C>T	uc010kuk.2	-	4	736	c.616G>A	c.(616-618)GAG>AAG	p.E206K	CDCA7L_uc003sve.3_Missense_Mutation_p.E172K|CDCA7L_uc010kul.2_Missense_Mutation_p.E160K|CDCA7L_uc003svf.3_Missense_Mutation_p.E205K|CDCA7L_uc011jyk.1_Missense_Mutation_p.E206K	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	206					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						TCCTGGCTCTCATCCCGAGAG	0.463													22	49					0	0	0	0	T	21947813	T	T	21947813	3	4	36	1	0	0	0	0	1	0	0	0	3106	835	29	2	776	2	CDCA7L	7	21947813	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3322877	21947813	137190850	404	7204											
MPP6	51678	broad.mit.edu	37	chr7	24703280	24703280	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttgcaaagaagcaggattGaagttttccaaaggagagat	15	9	11	6	0	0	3	0	1	0	2	1	6	1	5	2	2	2	3	2	2	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:24703280G>A	uc003swx.2	+	7	1022	c.723G>A	c.(721-723)TTG>TTA	p.L241L	MPP6_uc003swy.2_Silent_p.L241L|MPP6_uc010kur.2_5'Flank	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	241	SH3.				protein complex assembly		protein binding				0						AAGCAGGATTGAAGTTTTCCA	0.338													41	114					0	0	0	0	A	24703280	A	A	24703280	2	1	36	1	0	0	0	0	0	0	0	1	9791	1281	45	2		2	MPP6	7	24703280	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2755467	24703280	134435383	405	7205											
TBX20	57057	broad.mit.edu	37	chr7	35242187	35242187	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatggagctggcaatggccGatggtgtcagaggcattccc	8	8	15	10	1	1	1	1	0	0	1	2	3	2	2	2	5	1	4	2	5	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:35242187G>T	uc011kas.1	-	8	1210	c.1199C>A	c.(1198-1200)TCG>TAG	p.S400*		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	400						nucleus	DNA binding			central_nervous_system(1)	1						GGCAATGGCCGATGGTGTCAG	0.562													16	51					9.7654e-05	0.000100024	1	0	T	35242187	T	T	35242187	4	4	36	1	0	0	0	0	0	1	0	0	15722	1059	37	3	147	3	TBX20	7	35242187	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	10538907	35242187	123896476	406	7206											
VPS41	27072	broad.mit.edu	37	chr7	38785180	38785180	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaagataaactgtctcttCtacaaagtttctctgttgac	12	14	6	9	0	3	3	0	1	3	2	5	3	3	3	0	0	2	2	0	0	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:38785180C>G	uc003tgy.2	-	23	1986	c.1960G>C	c.(1960-1962)GAA>CAA	p.E654Q	VPS41_uc003tgz.2_Missense_Mutation_p.E629Q|VPS41_uc010kxn.2_Missense_Mutation_p.E565Q|VPS41_uc003tgx.2_RNA	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	654	Clathrin.				Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						ACTGTCTCTTCTACAAAGTTT	0.338													62	167					0	0	0	0	G	38785180	G	G	38785180	3	3	36	1	0	0	0	0	1	0	0	0	17278	922	32	2	632	2	VPS41	7	38785180	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3542993	38785180	120353483	407	7207											
CDK13	8621	broad.mit.edu	37	chr7	40134276	40134276	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatatggagacatttacctCaatgctggtcccatgttgtt	9	14	10	8	0	1	1	1	0	0	1	2	3	2	2	2	3	2	3	2	3	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:40134276C>T	uc003thh.3	+	14	4518	c.4236C>T	c.(4234-4236)CTC>CTT	p.L1412L	CDK13_uc003thi.3_Silent_p.L1352L|CDK13_uc003thj.2_Silent_p.L463L|CDK13_uc003thk.2_Silent_p.L345L	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	1412					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						ACATTTACCTCAATGCTGGTC	0.473													82	235					0	0	0	0	T	40134276	T	T	40134276	2	4	36	1	0	0	0	0	0	0	0	1	3144	813	29	2		2	CDK13	7	40134276	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1349096	40134276	119004387	408	7208											
ADCY1	107	broad.mit.edu	37	chr7	45662289	45662289	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	catcccagtgcacagcccagGagctggtgaaactcctcaat	11	7	9	14	0	1	1	1	1	0	0	3	2	3	2	3	2	4	2	3	2	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:45662289G>C	uc003tne.3	+	4	985	c.967G>C	c.(967-969)GAG>CAG	p.E323Q	ADCY1_uc003tnd.2_Missense_Mutation_p.E98Q	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	323	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CACAGCCCAGGAGCTGGTGAA	0.507													10	65					0	0	0	0	C	45662289	C	C	45662289	3	2	36	1	0	0	0	0	1	0	0	0	292	1175	41	2	981	2	ADCY1	7	45662289	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5528013	45662289	113476374	409	7209											
ABCA13	154664	broad.mit.edu	37	chr7	48314889	48314889	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagattcaccatgttcaaatGaaagctcccgaatggaaata	17	9	7	8	1	2	2	2	1	0	1	3	4	3	3	2	1	1	2	2	1	6	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:48314889G>C	uc003toq.2	+	17	5651	c.5626G>C	c.(5626-5628)GAA>CAA	p.E1876Q	ABCA13_uc010kyr.2_Missense_Mutation_p.E1379Q	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1876					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ATGTTCAAATGAAAGCTCCCG	0.423													33	98					0	0	0	0	C	48314889	C	C	48314889	3	2	36	1	0	0	0	0	1	0	0	0	31	1291	45	2	5521	2	ABCA13	7	48314889	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2652600	48314889	110823774	410	7210											
ABCA13	154664	broad.mit.edu	37	chr7	48315502	48315502	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagaatcagacacctgctttCtgaaatgaacaaaggaatca	17	9	7	8	0	3	4	2	2	1	2	3	5	3	5	1	1	2	1	1	1	6	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:48315502C>G	uc003toq.2	+	17	6264	c.6239C>G	c.(6238-6240)TCT>TGT	p.S2080C	ABCA13_uc010kyr.2_Missense_Mutation_p.S1583C	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2080					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CACCTGCTTTCTGAAATGAAC	0.363													15	52					0	0	0	0	G	48315502	G	G	48315502	3	3	36	1	0	0	0	0	1	0	0	0	31	913	32	2	6134	2	ABCA13	7	48315502	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	613	48315502	110823161	411	7211											
COBL	23242	broad.mit.edu	37	chr7	51095705	51095705	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctccctgctgcaggcctGagtgtcagatgtgtgtggag	6	10	15	10	0	1	2	1	1	0	1	2	3	2	3	2	2	3	3	2	2	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:51095705G>C	uc003tpr.3	-	10	3273	c.3088C>G	c.(3088-3090)CAG>GAG	p.Q1030E	COBL_uc003tps.2_Missense_Mutation_p.Q1087E|COBL_uc011kcl.1_Missense_Mutation_p.Q1030E|COBL_uc003tpp.3_Missense_Mutation_p.Q816E|COBL_uc003tpq.3_Missense_Mutation_p.Q971E|COBL_uc003tpo.3_Missense_Mutation_p.Q572E	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	1030										skin(3)|ovary(2)	5	Glioma(55;0.08)					CTGCAGGCCTGAGTGTCAGAT	0.622													29	80					0	0	0	0	C	51095705	C	C	51095705	3	2	36	1	0	0	0	0	1	0	0	0	3668	1299	45	2	713	2	COBL	7	51095705	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2780203	51095705	108042958	412	7212											
POM121L12	285877	broad.mit.edu	37	chr7	53103598	53103598	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtgcccagcacccacctcatCgaggtgcggcccacccagga	8	4	11	18	2	1	0	1	0	0	0	2	2	1	1	5	3	3	1	5	3	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:53103598C>G	uc003tpz.2	+	1	250	c.234C>G	c.(232-234)ATC>ATG	p.I78M		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	78											0						CCCACCTCATCGAGGTGCGGC	0.716													4	27					0	0	0	0	G	53103598	G	G	53103598	3	3	36	1	0	0	0	0	1	0	0	0	12296	874	31	3	236	3	POM121L12	7	53103598	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2007893	53103598	106035065	413	7213											
RABGEF1	27342	broad.mit.edu	37	chr7	66248715	66248715	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaccggcaaaccagcattGaaacggatagagtgtctaag	16	7	10	8	2	1	2	0	1	1	1	1	3	1	3	2	2	4	2	2	2	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:66248715G>A	uc011kee.1	+	4	606	c.442G>A	c.(442-444)GAA>AAA	p.E148K	RABGEF1_uc003tvf.2_5'UTR|RABGEF1_uc003tvg.2_Intron|RABGEF1_uc010lag.2_Missense_Mutation_p.E134K|RABGEF1_uc003tvh.2_Missense_Mutation_p.E134K|RABGEF1_uc003tvi.2_5'UTR	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	312					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						AACCAGCATTGAAACGGATAG	0.393													23	50					0	0	0	0	A	66248715	A	A	66248715	3	1	36	1	0	0	0	0	1	0	0	0	13031	1291	45	2	410	2	RABGEF1	7	66248715	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	13145117	66248715	92889948	414	7214											
DNAJC30	84277	broad.mit.edu	37	chr7	73097515	73097515	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctccgcgctcccggagttgCggtccgggtggtagagaaag	6	7	16	12	5	0	1	0	0	0	1	3	3	3	2	4	4	1	3	4	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:73097515C>T	uc003tys.1	-	1	267	c.239G>A	c.(238-240)CGC>CAC	p.R80H	WBSCR22_uc010lbi.1_5'Flank|WBSCR22_uc003tyt.2_5'Flank|WBSCR22_uc003tyu.2_5'Flank|WBSCR22_uc003tyv.2_5'Flank|WBSCR22_uc003tyw.1_5'Flank	NM_032317	NP_115693	Q96LL9	DJC30_HUMAN	DnaJ (Hsp40) homolog subfamily C member 30	80	J.				protein folding		heat shock protein binding|unfolded protein binding				0						CCCGGAGTTGCGGTCCGGGTG	0.667													4	133					0	0	0	0	T	73097515	T	T	73097515	3	4	36	1	0	0	0	0	1	0	0	0	4670	768	27	1	445	1	DNAJC30	7	73097515	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6848800	73097515	86041148	415	7215											
LIMK1	3984	broad.mit.edu	37	chr7	73523309	73523309	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctacaaggacaagaggctCaacttcatcactgagtacat	14	9	7	11	0	4	2	3	1	1	1	4	3	4	3	0	2	3	2	0	2	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:73523309C>G	uc003uaa.1	+	10	1392	c.1227C>G	c.(1225-1227)CTC>CTG	p.L409L	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Silent_p.L375L|LIMK1_uc003uac.1_Silent_p.L201L	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	409	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				ACAAGAGGCTCAACTTCATCA	0.413													19	31					0	0	0	0	G	73523309	G	G	73523309	2	3	36	1	0	0	0	0	0	0	0	1	8842	813	29	2		2	LIMK1	7	73523309	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	425794	73523309	85615354	416	7216											
CACNA2D1	781	broad.mit.edu	37	chr7	81603800	81603800	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtttggagtttttctatcaAtaaactcgttgaaatttaaa	13	18	6	4	1	2	1	1	1	1	0	3	2	2	2	0	1	1	3	0	1	7	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:81603800A>C	uc003uhr.1	-	25	2280	c.2024T>G	c.(2023-2025)ATT>AGT	p.I675S		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	687	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TTTTCTATCAATAAACTCGTT	0.284													3	38					0	0	0	0	C	81603800	C	C	81603800	3	2	36	1	0	0	0	0	1	0	0	0	2560	101	4	5	1311	5	CACNA2D1	7	81603800	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	8080491	81603800	77534863	417	7217											
PCLO	27445	broad.mit.edu	37	chr7	82474791	82474791	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggatcaacccctggggatttCgccttatccactacaacaaa	12	9	7	13	1	1	0	1	0	0	0	3	2	2	2	4	3	3	0	4	3	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:82474791C>T	uc003uhx.2	-	13	14131	c.13842G>A	c.(13840-13842)GCG>GCA	p.A4614A	PCLO_uc003uhv.2_Silent_p.A4614A|PCLO_uc003uht.1_Silent_p.A65A|PCLO_uc003uhu.1_Silent_p.A44A	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4502					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGGGGATTTCGCCTTATCCA	0.418													6	19					0	0	0	0	T	82474791	T	T	82474791	2	4	36	1	0	0	0	0	0	0	0	1	11637	871	31	1		1	PCLO	7	82474791	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	870991	82474791	76663872	418	7218											
PCLO	27445	broad.mit.edu	37	chr7	82545543	82545543	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggctgagtctgataaggtGaaacttgctgatggtacaaa	12	12	12	5	0	1	4	0	4	1	0	1	4	1	4	0	3	3	3	0	3	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:82545543G>A	uc003uhx.2	-	7	12048	c.11759C>T	c.(11758-11760)TCA>TTA	p.S3920L	PCLO_uc003uhv.2_Missense_Mutation_p.S3920L|PCLO_uc010lec.2_Missense_Mutation_p.S885L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3851	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGATAAGGTGAAACTTGCTG	0.463													114	440					0	0	0	0	A	82545543	A	A	82545543	3	1	36	1	0	0	0	0	1	0	0	0	11637	1294	45	2	3762	2	PCLO	7	82545543	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	70752	82545543	76593120	419	7219											
GRM3	2913	broad.mit.edu	37	chr7	86468181	86468181	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaacccaaataaagatgcaGatagcatagtcaagtttgac	17	9	7	8	0	2	3	2	1	0	2	2	3	2	3	1	0	3	3	1	0	7	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:86468181G>C	uc003uid.2	+	4	2450	c.1351G>C	c.(1351-1353)GAT>CAT	p.D451H	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.D323H|GRM3_uc010leh.2_Missense_Mutation_p.D43H	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	451	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TAAAGATGCAGATAGCATAGT	0.358													5	34					0	0	0	0	C	86468181	C	C	86468181	3	2	36	1	0	0	0	0	1	0	0	0	6837	942	33	2	1361	2	GRM3	7	86468181	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3922638	86468181	72670482	420	7220											
GRM3	2913	broad.mit.edu	37	chr7	86468291	86468291	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaagttggtcactgggcAgaaaccttatcgctagatgt	11	12	11	7	1	1	3	1	1	0	2	2	3	1	3	1	2	1	3	1	2	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:86468291A>T	uc003uid.2	+	4	2560	c.1461A>T	c.(1459-1461)GCA>GCT	p.A487A	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Silent_p.A359A|GRM3_uc010leh.2_Silent_p.A79A	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	487	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GTCACTGGGCAGAAACCTTAT	0.468													21	51					0	0	0	0	T	86468291	T	T	86468291	2	4	36	1	0	0	0	0	0	0	0	1	6837	175	7	5		5	GRM3	7	86468291	Silent	SNP	A	TCGA-CN-4723-01A-01D-1434-08	110	86468291	72670372	421	7221											
ABCB1	5243	broad.mit.edu	37	chr7	87195516	87195516	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccattgactgaaagaacattCcaattttgtcaccaattcct	13	13	4	11	0	1	3	1	2	0	1	3	3	3	3	4	0	1	0	4	0	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:87195516C>G	uc003uiz.1	-	8	990	c.572G>C	c.(571-573)GGA>GCA	p.G191A	ABCB1_uc011khc.1_Missense_Mutation_p.G127A	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	191	Helical; (Potential).|ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AAAGAACATTCCAATTTTGTC	0.363													5	150					0	0	0	0	G	87195516	G	G	87195516	3	3	36	1	0	0	0	0	1	0	0	0	40	855	30	2	3358	2	ABCB1	7	87195516	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	727225	87195516	71943147	422	7222											
ADAM22	53616	broad.mit.edu	37	chr7	87564431	87564431	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actgcgcctcatctaccgctCgggcggcgaagacgaaagtc	9	6	12	14	6	2	1	1	0	1	1	4	3	2	1	2	2	2	1	2	2	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:87564431C>T	uc003ujn.2	+	2	255	c.176C>T	c.(175-177)TCG>TTG	p.S59L	ADAM22_uc003uji.1_Missense_Mutation_p.S58L|ADAM22_uc003ujj.1_Missense_Mutation_p.S59L|ADAM22_uc003ujk.1_Missense_Mutation_p.S59L|ADAM22_uc003ujl.1_Missense_Mutation_p.S59L|ADAM22_uc003ujm.2_Missense_Mutation_p.S59L|ADAM22_uc003ujo.2_Missense_Mutation_p.S59L|ADAM22_uc003ujp.1_Missense_Mutation_p.S111L	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	59					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			ATCTACCGCTCGGGCGGCGAA	0.667													15	52					0	0	0	0	T	87564431	T	T	87564431	3	4	36	1	0	0	0	0	1	0	0	0	244	893	31	1	182	1	ADAM22	7	87564431	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	368915	87564431	71574232	423	7223											
C7orf63	79846	broad.mit.edu	37	chr7	89906554	89906554	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcaaaatcttttggtaaaagGacttaagctttctaattcct	13	16	5	7	0	3	0	1	0	2	0	4	1	4	1	1	2	1	2	1	2	6	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:89906554G>C	uc010lep.2	+	11	1312	c.1061G>C	c.(1060-1062)GGA>GCA	p.G354A	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_Missense_Mutation_p.G29A|C7orf63_uc011khj.1_Missense_Mutation_p.G336A|C7orf63_uc011khk.1_5'Flank	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	354							binding			ovary(1)	1						TTGGTAAAAGGACTTAAGCTT	0.274													9	70					0	0	0	0	C	89906554	C	C	89906554	3	2	36	1	0	0	0	0	1	0	0	0	2420	1174	41	2	1103	2	C7orf63	7	89906554	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2342123	89906554	69232109	424	7224											
COL1A2	1278	broad.mit.edu	37	chr7	94049587	94049587	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgctggtcctgctggtcctCggggaagccctgtaagtaag	6	10	14	11	1	0	0	0	0	0	0	3	1	2	1	3	4	3	4	3	4	3	2	rs139199272		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:94049587C>T	uc003ung.1	+	35	2593	c.2122C>T	c.(2122-2124)CGG>TGG	p.R708W	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	708			R -> Q (in Marfan syndrome).|Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	tgctggtcctCGGGGAAGCCC	0.353										HNSCC(75;0.22)			45	126					0	0	0	0	T	94049587	T	T	94049587	3	4	36	1	0	0	0	0	1	0	0	0	3693	875	31	1	2260	1	COL1A2	7	94049587	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4143033	94049587	65089076	425	7225											
PEG10	23089	broad.mit.edu	37	chr7	94293385	94293385	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccaaacgcaagatcagaCgcctgcgccaaggcatgggg	11	5	13	12	3	1	2	1	0	0	2	1	2	1	2	3	3	3	2	3	3	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:94293385C>T	uc011kie.1	+	2	962	c.745C>T	c.(745-747)CGC>TGC	p.R249C		NM_001040152	NP_001035242	Q86TG7	PEG10_HUMAN	paternally expressed 10 isoform RF1	173	Necessary for interaction with ALK1.				apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CAAGATCAGACGCCTGCGCCA	0.527													61	229					0	0	0	0	T	94293385	T	T	94293385	3	4	36	1	0	0	0	0	1	0	0	0	11773	536	19	1	751	1	PEG10	7	94293385	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	243798	94293385	64845278	426	7226											
PPP1R9A	55607	broad.mit.edu	37	chr7	94881322	94881322	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactgaagcaaaatgggactCaagttaacaataataacaac	20	8	6	7	0	1	1	1	1	0	0	1	2	1	2	0	1	5	2	0	1	10	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:94881322C>G	uc003unp.2	+	11	2761	c.2479C>G	c.(2479-2481)CAA>GAA	p.Q827E	PPP1R9A_uc010lfj.2_Missense_Mutation_p.Q849E|PPP1R9A_uc011kif.1_Missense_Mutation_p.Q827E|PPP1R9A_uc003unq.2_Missense_Mutation_p.Q827E|PPP1R9A_uc011kig.1_Missense_Mutation_p.Q827E	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	827	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAATGGGACTCAAGTTAACAA	0.398										HNSCC(28;0.073)			21	90					0	0	0	0	G	94881322	G	G	94881322	3	3	36	1	0	0	0	0	1	0	0	0	12438	827	29	2	2587	2	PPP1R9A	7	94881322	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	587937	94881322	64257341	427	7227											
GIGYF1	64599	broad.mit.edu	37	chr7	100279772	100279772	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttggcaaattctttggcttCcagcgtgtcccccaggcagg	6	12	11	12	1	1	0	0	0	1	0	3	0	3	0	3	4	1	3	3	4	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:100279772C>T	uc003uwg.1	-	22	3857	c.2848G>A	c.(2848-2850)GAA>AAA	p.E950K		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	950										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TCTTTGGCTTCCAGCGTGTCC	0.438													24	68					0	0	0	0	T	100279772	T	T	100279772	3	4	36	1	0	0	0	0	1	0	0	0	6414	864	30	2	271	2	GIGYF1	7	100279772	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5398450	100279772	58858891	428	7228											
MUC17	140453	broad.mit.edu	37	chr7	100677779	100677779	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcacctcctcccactgctGaaggtaccagcatgccaacc	9	8	7	17	0	1	1	1	1	0	0	3	1	3	1	6	1	5	4	6	1	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:100677779G>A	uc003uxp.1	+	3	3135	c.3082G>A	c.(3082-3084)GAA>AAA	p.E1028K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1028	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|15.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCCACTGCTGAAGGTACCAG	0.517													152	419					0	0	0	0	A	100677779	A	A	100677779	3	1	36	1	0	0	0	0	1	0	0	0	10027	1291	45	2	3092	2	MUC17	7	100677779	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	398007	100677779	58460884	429	7229											
MUC17	140453	broad.mit.edu	37	chr7	100683350	100683350	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacgccggtggccagttctGaggctagcaccctttcaaca	8	8	10	15	2	2	1	1	1	1	0	2	1	2	1	4	3	2	3	4	3	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:100683350G>A	uc003uxp.1	+	3	8706	c.8653G>A	c.(8653-8655)GAG>AAG	p.E2885K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2885	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|46.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGCCAGTTCTGAGGCTAGCAC	0.483													145	425					0	0	0	0	A	100683350	A	A	100683350	3	1	36	1	0	0	0	0	1	0	0	0	10027	1291	45	2	8663	2	MUC17	7	100683350	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5571	100683350	58455313	430	7230											
MUC17	140453	broad.mit.edu	37	chr7	100683466	100683466	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcatgccaatctcaactccTagtgaagtaagtactccatt	13	11	6	11	0	1	1	1	1	1	0	4	1	3	1	3	0	4	3	3	0	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:100683466T>C	uc003uxp.1	+	3	8822	c.8769T>C	c.(8767-8769)CCT>CCC	p.P2923P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2923	Extracellular (Potential).|47.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCTCAACTCCTAGTGAAGTAA	0.483													154	355					0	0	0	0	C	100683466	C	C	100683466	2	2	36	1	0	0	0	0	0	0	0	1	10027	1509	53	5		5	MUC17	7	100683466	Silent	SNP	T	TCGA-CN-4723-01A-01D-1434-08	116	100683466	58455197	431	7231											
MUC17	140453	broad.mit.edu	37	chr7	100684033	100684033	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccattaacaggtgtgcctgtCagcaccacaccggtgaccag	10	7	10	14	1	1	1	1	1	0	0	1	1	1	1	5	2	3	1	5	2	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:100684033C>G	uc003uxp.1	+	3	9389	c.9336C>G	c.(9334-9336)GTC>GTG	p.V3112V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3112	Extracellular (Potential).|Ser-rich.|50.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTGTGCCTGTCAGCACCACAC	0.493													157	397					0	0	0	0	G	100684033	G	G	100684033	2	3	36	1	0	0	0	0	0	0	0	1	10027	813	29	2		2	MUC17	7	100684033	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	567	100684033	58454630	432	7232											
C7orf52	375607	broad.mit.edu	37	chr7	100815677	100815677	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcggctgtccacgcgccactCcaggcccttggccgccagca	5	5	12	19	4	0	0	0	0	0	0	2	0	2	0	6	3	1	2	6	3	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:100815677C>G	uc003uxy.1	-	4	1032	c.793G>C	c.(793-795)GAG>CAG	p.E265Q	C7orf52_uc003uxz.1_Missense_Mutation_p.E265Q	NM_198571	NP_940973	Q8N8M0	CG052_HUMAN	hypothetical protein LOC375607	265							N-acetyltransferase activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					ACGCGCCACTCCAGGCCCTTG	0.711													3	10					0	0	0	0	G	100815677	G	G	100815677	3	3	36	1	0	0	0	0	1	0	0	0	2412	864	30	2	320	2	C7orf52	7	100815677	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	131644	100815677	58322986	433	7233											
PRKRIP1	79706	broad.mit.edu	37	chr7	102047920	102047920	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaattactggcaaagaagatGaaacttgaacagaagaaaca	22	6	8	5	0	0	6	0	2	0	4	0	6	0	6	0	1	4	1	0	1	8	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:102047920G>A	uc003uzh.2	+	5	487	c.432G>A	c.(430-432)ATG>ATA	p.M144I	PRKRIP1_uc003uzf.2_Missense_Mutation_p.M93I|PRKRIP1_uc003uzg.2_Missense_Mutation_p.M93I|PRKRIP1_uc011kkq.1_Missense_Mutation_p.M87I|PRKRIP1_uc011kkr.1_Intron|MIR548O_hsa-mir-548o|MI0006402_5'Flank	NM_024653	NP_078929	Q9H875	PKRI1_HUMAN	PRKR interacting protein 1 (IL11 inducible)	144	Potential.					nucleolus				ovary(1)	1						CAAAGAAGATGAAACTTGAAC	0.353													19	36					0	0	0	0	A	102047920	A	A	102047920	3	1	36	1	0	0	0	0	1	0	0	0	12587	1290	45	2	450	2	PRKRIP1	7	102047920	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1232243	102047920	57090743	434	7234											
SLC26A5	375611	broad.mit.edu	37	chr7	103014907	103014907	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcctgggaagggggagccGaggcttcctgttcagcaagt	7	8	15	11	1	1	0	1	0	0	0	3	3	3	2	4	4	2	3	4	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:103014907G>A	uc003vbz.2	-	20	2410	c.2174C>T	c.(2173-2175)TCG>TTG	p.S725L	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.S693L|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	725	Cytoplasmic (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						AGGGGGAGCCGAGGCTTCCTG	0.532													26	68					0	0	0	0	A	103014907	A	A	103014907	3	1	36	1	0	0	0	0	1	0	0	0	14584	1059	37	1	105	1	SLC26A5	7	103014907	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	966987	103014907	56123756	435	7235											
RINT1	60561	broad.mit.edu	37	chr7	105189098	105189098	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaggttatgctgactcctCttcagaagaggttcaggtat	9	13	10	9	0	3	3	2	1	1	2	5	3	5	3	2	3	1	4	2	3	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:105189098C>G	uc003vda.1	+	7	1168	c.937C>G	c.(937-939)CTT>GTT	p.L313V	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	313	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						GCTGACTCCTCTTCAGAAGAG	0.463													5	349					0	0	0	0	G	105189098	G	G	105189098	3	3	36	1	0	0	0	0	1	0	0	0	13441	913	32	2	963	2	RINT1	7	105189098	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2174191	105189098	53949565	436	7236											
CDHR3	222256	broad.mit.edu	37	chr7	105624678	105624678	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaagagcaaaccctggattCatttaccaggttgaggcctt	12	10	10	9	0	1	2	1	1	0	1	1	4	1	3	3	3	3	2	3	3	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:105624678C>T	uc003vdl.3	+	4	564	c.456C>T	c.(454-456)TTC>TTT	p.F152F	CDHR3_uc003vdk.2_5'UTR|CDHR3_uc011kls.1_Intron|CDHR3_uc003vdm.3_Silent_p.F139F|CDHR3_uc011klt.1_Silent_p.F64F	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	152	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						ACCCTGGATTCATTTACCAGG	0.438													8	45					0	0	0	0	T	105624678	T	T	105624678	2	4	36	1	0	0	0	0	0	0	0	1	3135	825	29	2		2	CDHR3	7	105624678	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	435580	105624678	53513985	437	7237											
THAP5	168451	broad.mit.edu	37	chr7	108204874	108204874	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaatgttcgatttgtaaaaCttctgtcccatagtctacat	12	15	6	8	1	2	1	0	0	2	1	4	2	3	1	1	0	2	2	1	0	5	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:108204874C>G	uc003vfm.2	-	3	1103	c.949G>C	c.(949-951)GTT>CTT	p.V317L	THAP5_uc003vfl.2_Missense_Mutation_p.V275L	NM_001130475	NP_001123947	Q7Z6K1	THAP5_HUMAN	THAP domain containing 5 isoform 1	317					cell cycle|negative regulation of cell cycle	nucleus	DNA binding|metal ion binding|protease binding				0						ATTTGTAAAACTTCTGTCCCA	0.348													54	191					0	0	0	0	G	108204874	G	G	108204874	3	3	36	1	0	0	0	0	1	0	0	0	15913	565	20	4	242	4	THAP5	7	108204874	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2580196	108204874	50933789	438	7238											
CFTR	1080	broad.mit.edu	37	chr7	117243763	117243763	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catactctaatcacagtgtcGaaaattttacaccacaaaat	17	11	3	10	1	2	0	1	0	1	0	3	1	2	0	1	0	2	0	1	0	7	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:117243763G>A	uc003vjd.2	+	17	2967	c.2835G>A	c.(2833-2835)TCG>TCA	p.S945S	CFTR_uc011knq.1_Silent_p.S351S	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	945	Cytoplasmic (Potential).|ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TCACAGTGTCGAAAATTTTAC	0.398									Cystic_Fibrosis				49	118					0	0	0	0	A	117243763	A	A	117243763	2	1	36	1	0	0	0	0	0	0	0	1	3309	1045	37	1		1	CFTR	7	117243763	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	9038889	117243763	41894900	439	7239											
KCND2	3751	broad.mit.edu	37	chr7	119915729	119915729	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tatgttctacgcagagaaggGgtcttcggctagcaagttca	10	11	12	8	2	3	1	1	0	2	1	4	2	3	1	0	3	2	5	0	3	5	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:119915729G>T	uc003vjj.1	+	1	2008	c.1043G>T	c.(1042-1044)GGG>GTG	p.G348V		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	348					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GCAGAGAAGGGGTCTTCGGCT	0.493													36	145					9.85521e-28	1.05536e-27	1	0	T	119915729	T	T	119915729	3	4	36	1	0	0	0	0	1	0	0	0	8058	1232	43	4	1045	4	KCND2	7	119915729	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2671966	119915729	39222934	440	7240											
PTN	5764	broad.mit.edu	37	chr7	137028320	137028320	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctctccccgccttctggacgGatgactcactggtctctttc	4	13	8	16	2	4	1	1	1	3	0	7	3	4	3	3	3	0	0	3	3	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:137028320G>C	uc003vtq.2	-	1	227	c.-136C>G	c.(-138--134)ATCCG>ATGCG		PTN_uc010lmx.2_Translation_Start_Site|PTN_uc003vtr.1_Translation_Start_Site	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin						nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			upper_aerodigestive_tract(1)|pancreas(1)	2						CTTCTGGACGGATGACTCACT	0.607													21	66					0	0	0	0	C	137028320	C	C	137028320	1	2	36	1	0	0	0	0	0	0	0	0	12831	1189	41	2		2	PTN	7	137028320	Translation_Start_Site	SNP	G	TCGA-CN-4723-01A-01D-1434-08	17112591	137028320	22110343	441	7241											
TRIM24	8805	broad.mit.edu	37	chr7	138235861	138235861	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgtgatgcatccccagtGaccaacaacaccatccaatt	13	8	7	13	0	0	2	0	2	0	0	2	2	2	2	5	1	3	1	5	1	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:138235861G>A	uc003vuc.2	+	8	1412	c.1197G>A	c.(1195-1197)GTG>GTA	p.V399V	TRIM24_uc003vub.2_Silent_p.V399V	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	399					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						CATCCCCAGTGACCAACAACA	0.403													42	154					0	0	0	0	A	138235861	A	A	138235861	2	1	36	1	0	0	0	0	0	0	0	1	16565	1277	45	2		2	TRIM24	7	138235861	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1207541	138235861	20902802	442	7242											
TBXAS1	6916	broad.mit.edu	37	chr7	139572057	139572057	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccacatcagcattctcaaGactggagaagttaggcctca	12	9	8	12	0	3	2	3	0	1	2	5	3	4	2	2	2	1	2	2	2	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:139572057G>C	uc011kqv.1	+	2	280	c.116G>C	c.(115-117)AGA>ACA	p.R39T	TBXAS1_uc003vvh.2_Missense_Mutation_p.R39T|TBXAS1_uc010lne.2_5'UTR|TBXAS1_uc011kqu.1_Intron|TBXAS1_uc003vvi.2_Missense_Mutation_p.R39T|TBXAS1_uc003vvj.2_Missense_Mutation_p.R39T|TBXAS1_uc011kqw.1_Missense_Mutation_p.K9N|TBXAS1_uc011kqx.1_Missense_Mutation_p.R39T	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	38	Lumenal (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					GCATTCTCAAGACTGGAGAAG	0.443													62	162					0	0	0	0	C	139572057	C	C	139572057	3	2	36	1	0	0	0	0	1	0	0	0	15730	942	33	2	122	2	TBXAS1	7	139572057	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1336196	139572057	19566606	443	7243											
MGAM	8972	broad.mit.edu	37	chr7	141752582	141752582	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgactttggccttacttttcAggcatccaattcttctggag	7	16	8	10	0	3	1	1	1	2	0	4	2	4	2	2	3	1	1	2	3	2	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:141752582A>G	uc003vwy.2	+	26	3013	c.2959_splice	c.e26-2	p.A987_splice		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase						polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTTACTTTTCAGGCATCCAAT	0.398													3	173					0	0	0	0	G	141752582	G	G	141752582	5	3	36	1	0	0	0	0	0	0	1	0	9594	202	7	5	3055	5	MGAM	7	141752582	Splice_Site	SNP	A	TCGA-CN-4723-01A-01D-1434-08	2180525	141752582	17386081	444	7244											
FAM115A	9747	broad.mit.edu	37	chr7	143573509	143573509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcttccaccaagtagtcctCatgggacacgaccaccaggc	10	6	10	15	1	1	0	1	0	0	0	3	2	3	1	5	3	0	2	5	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:143573509C>T	uc003wdo.1	-	2	326	c.193G>A	c.(193-195)GAG>AAG	p.E65K	FAM115A_uc011ktu.1_Intron|FAM115A_uc003wdp.1_Missense_Mutation_p.E65K	NM_014719	NP_055534	Q9Y4C2	F115A_HUMAN	hypothetical protein LOC9747	65											0	Melanoma(164;0.0903)					AAGTAGTCCTCATGGGACACG	0.587													16	58					0	0	0	0	T	143573509	T	T	143573509	3	4	36	1	0	0	0	0	1	0	0	0	5433	835	29	2	2604	2	FAM115A	7	143573509	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1820927	143573509	15565154	445	7245											
TPK1	27010	broad.mit.edu	37	chr7	144288620	144288620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagatgccataatctggtCaaaacgcccagcaaggcctc	13	6	8	14	1	2	1	1	0	1	1	3	1	2	1	3	2	3	1	3	2	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:144288620C>T	uc003weq.2	-	7	500	c.397G>A	c.(397-399)GAC>AAC	p.D133N	TPK1_uc003weo.2_Intron|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Intron|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	133					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	ATAATCTGGTCAAAACGCCCA	0.428													35	118					0	0	0	0	T	144288620	T	T	144288620	3	4	36	1	0	0	0	0	1	0	0	0	16471	826	29	2	346	2	TPK1	7	144288620	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	715111	144288620	14850043	446	7246											
ZNF282	8427	broad.mit.edu	37	chr7	148895519	148895519	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttccccgaccgcatgatgcGagagccccagttgcccacag	8	6	10	17	3	0	2	0	1	0	1	1	4	1	2	6	0	3	2	6	0	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:148895519G>A	uc003wfm.2	+	2	365	c.260G>A	c.(259-261)CGA>CAA	p.R87Q	ZNF282_uc011kun.1_Missense_Mutation_p.R87Q|ZNF282_uc003wfn.2_Missense_Mutation_p.R27Q|ZNF282_uc003wfo.2_Missense_Mutation_p.R27Q	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	87					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CGCATGATGCGAGAGCCCCAG	0.602													24	84					0	0	0	0	A	148895519	A	A	148895519	3	1	36	1	0	0	0	0	1	0	0	0	17886	1058	37	1	266	1	ZNF282	7	148895519	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4606899	148895519	10243144	447	7247											
ZNF777	27153	broad.mit.edu	37	chr7	149152780	149152780	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaagggagacttcttgttCagcagcagctgggggtggat	9	9	17	6	0	2	2	1	0	1	2	2	5	2	3	0	4	3	4	0	4	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:149152780C>G	uc003wfv.2	-	2	497	c.334G>C	c.(334-336)GAA>CAA	p.E112Q		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			ACTTCTTGTTCAGCAGCAGCT	0.612													8	225					0	0	0	0	G	149152780	G	G	149152780	3	3	36	1	0	0	0	0	1	0	0	0	18217	835	29	2	2181	2	ZNF777	7	149152780	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	257261	149152780	9985883	448	7248											
ZNF746	155061	broad.mit.edu	37	chr7	149171704	149171704	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgaagcttttgccgcagacgGtgcaggtgaagggccgcacg	8	7	16	10	4	0	3	0	2	0	1	0	3	0	3	2	3	3	4	2	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:149171704G>A	uc003wfw.2	-	7	1977	c.1706C>T	c.(1705-1707)ACC>ATC	p.T569I	ZNF746_uc010lpi.2_Missense_Mutation_p.T570I	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	569	C2H2-type 4.				negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GCCGCAGACGGTGCAGGTGAA	0.672													5	20					0	0	0	0	A	149171704	A	A	149171704	3	1	36	1	0	0	0	0	1	0	0	0	18196	1261	44	4	232	4	ZNF746	7	149171704	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	18924	149171704	9966959	449	7249											
GBX1	2636	broad.mit.edu	37	chr7	150845891	150845891	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgagggcgtgggcgatctGagagcgctctgtcaagctca	7	9	15	10	3	4	2	2	2	2	1	4	4	4	2	0	2	2	2	0	2	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:150845891G>C	uc011kvg.1	-	2	1109	c.877C>G	c.(877-879)CAG>GAG	p.Q293E		NM_001098834	NP_001092304	Q14549	GBX1_HUMAN	gastrulation brain homeo box 1	293	Homeobox.					nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGCGATCTGAGAGCGCTCT	0.532													38	91					0	0	0	0	C	150845891	C	C	150845891	3	2	36	1	0	0	0	0	1	0	0	0	6315	1299	45	2	217	2	GBX1	7	150845891	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1674187	150845891	8292772	450	7250											
ABCF2	10061	broad.mit.edu	37	chr7	150916225	150916225	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagctctagccgcgtcttCacgtactgatcataattacc	9	12	6	14	3	4	1	2	1	2	0	5	1	5	1	3	0	4	2	3	0	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:150916225C>T	uc003wjp.2	-	8	1053	c.942G>A	c.(940-942)GTG>GTA	p.V314V	ABCF2_uc003wjo.1_Silent_p.V314V	NM_007189	NP_009120	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F, member 2	314	ABC transporter 1.					ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCGCGTCTTCACGTACTGAT	0.502													71	201					0	0	0	0	T	150916225	T	T	150916225	2	4	36	1	0	0	0	0	0	0	0	1	66	813	29	2		2	ABCF2	7	150916225	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	70334	150916225	8222438	451	7251											
NOM1	64434	broad.mit.edu	37	chr7	156746954	156746954	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactgatgatggagcatgttCtcttagtcagcatccttcac	9	13	9	10	0	3	2	2	2	1	0	5	4	4	3	1	1	2	3	1	1	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:156746954C>T	uc003wmy.2	+	3	1285	c.1270C>T	c.(1270-1272)CTC>TTC	p.L424F		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	424	MIF4G.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GGAGCATGTTCTCTTAGTCAG	0.502													13	61					0	0	0	0	T	156746954	T	T	156746954	3	4	36	1	0	0	0	0	1	0	0	0	10584	913	32	2	1280	2	NOM1	7	156746954	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5830729	156746954	2391709	452	7252											
MNX1	3110	broad.mit.edu	37	chr7	156802973	156802973	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaaggccagcggcgcgctCtgcgcagaggcggctcgtgg	6	4	17	14	6	1	1	0	0	1	1	2	1	1	1	2	5	2	3	2	5	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:156802973C>G	uc003wnd.1	-	1	375	c.72G>C	c.(70-72)CAG>CAC	p.Q24H	MNX1_uc003wmz.2_5'Flank|MNX1_uc003wna.2_Missense_Mutation_p.Q24H|MNX1_uc010lqq.1_5'Flank|MNX1_uc003wnc.1_5'Flank|MNX1_uc010lqr.1_5'Flank|uc003wne.1_5'Flank	NM_005515	NP_005506	P50219	MNX1_HUMAN	motor neuron and pancreas homeobox 1 isoform 1	24				DALLAVDPPRAASAQSAPLALVTSLAAA -> EPCWRWTPH EPPLAERALAKVTSPPVP (in Ref. 1; AAB60647).	humoral immune response|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCGGCGCGCTCTGCGCAGAGG	0.562									Currarino_syndrome				3	13					0	0	0	0	G	156802973	G	G	156802973	3	3	36	1	0	0	0	0	1	0	0	0	9732	912	32	2	1204	2	MNX1	7	156802973	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	56019	156802973	2335690	453	7253											
UBE3C	9690	broad.mit.edu	37	chr7	156931979	156931979	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgccaggatgttcagcttcGaaggcgacttcaagacgcgg	9	8	13	11	4	2	1	2	0	0	1	3	4	2	2	1	3	2	2	1	3	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr7:156931979G>A	uc010lqs.2	+	1	325	c.13G>A	c.(13-15)GAA>AAA	p.E5K	UBE3C_uc003wnf.2_Missense_Mutation_p.E5K|UBE3C_uc003wng.2_Missense_Mutation_p.E5K	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	5	Cis-determinant of acceptor ubiquitin- binding.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		GTTCAGCTTCGAAGGCGACTT	0.557													4	23					0	0	0	0	A	156931979	A	A	156931979	3	1	36	1	0	0	0	0	1	0	0	0	16949	1059	37	1	15	1	UBE3C	7	156931979	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	129006	156931979	2206684	454	7254											
CSMD1	64478	broad.mit.edu	37	chr8	3226815	3226815	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatggtccacgtgcagtttaGagagtttggataaaaatctg	13	12	11	5	1	1	1	0	0	1	1	2	3	2	2	1	2	1	3	1	2	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:3226815G>C	uc011kwk.1	-	19	3253	c.2863C>G	c.(2863-2865)CTA>GTA	p.L955V	CSMD1_uc011kwj.1_Missense_Mutation_p.L347V|CSMD1_uc003wqe.2_Missense_Mutation_p.L111V	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	955	Extracellular (Potential).|CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGCAGTTTAGAGAGTTTGGA	0.398													5	32					0	0	0	0	C	3226815	C	C	3226815	3	2	36	1	0	0	0	0	1	0	0	0	3961	933	33	2	8042	2	CSMD1	8	3226815	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08		3226815	143137207	455	7255											
CLDN23	137075	broad.mit.edu	37	chr8	8560295	8560295	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgctggcctcctcggcctCatcccggtgtcctggtacaa	4	10	11	16	3	1	0	1	0	0	0	6	0	4	0	5	4	1	2	5	4	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:8560295C>A	uc003wsi.2	+	1	630	c.387C>A	c.(385-387)CTC>CTA	p.L129L		NM_194284	NP_919260	Q96B33	CLD23_HUMAN	claudin 23	129	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)		TCCTCGGCCTCATCCCGGTGT	0.701													12	18					4.3838e-07	4.52045e-07	1	0	A	8560295	A	A	8560295	2	1	36	1	0	0	0	0	0	0	0	1	3499	813	29	2		2	CLDN23	8	8560295	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5333480	8560295	137803727	456	7256											
RP1L1	94137	broad.mit.edu	37	chr8	10468185	10468185	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtaccgaggggagtctttGaacctcactttgctggcagg	7	11	14	9	1	2	1	1	1	1	0	2	3	2	2	2	5	3	3	2	5	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:10468185G>C	uc003wtc.2	-	4	3652	c.3423C>G	c.(3421-3423)TTC>TTG	p.F1141L		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1141					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GGGAGTCTTTGAACCTCACTT	0.592													20	85					0	0	0	0	C	10468185	C	C	10468185	3	2	36	1	0	0	0	0	1	0	0	0	13598	1281	45	2	3783	2	RP1L1	8	10468185	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1907890	10468185	135895837	457	7257											
DLC1	10395	broad.mit.edu	37	chr8	13356866	13356866	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttcatctttaggggggtCaggtttccttcgttgctgag	5	17	12	7	1	3	1	2	1	1	0	5	1	4	1	1	4	1	3	1	4	1	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:13356866C>T	uc003wwm.2	-	2	1159	c.715G>A	c.(715-717)GAC>AAC	p.D239N	DLC1_uc003wwn.2_Missense_Mutation_p.D239N|DLC1_uc011kxy.1_Missense_Mutation_p.D239N	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	239					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TTAGGGGGGTCAGGTTTCCTT	0.398													84	283					0	0	0	0	T	13356866	T	T	13356866	3	4	36	1	0	0	0	0	1	0	0	0	4572	826	29	2	4024	2	DLC1	8	13356866	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2888681	13356866	133007156	458	7258											
FGF20	26281	broad.mit.edu	37	chr8	16850803	16850803	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcaaactgctccctaaaGatgcattcggaagtaagttt	12	13	7	9	1	2	1	1	0	1	1	4	2	3	2	1	1	3	4	1	1	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:16850803G>T	uc003wxc.1	-	3	547	c.414C>A	c.(412-414)ATC>ATA	p.I138I	FGF20_uc010lsv.1_RNA|FGF20_uc010lsw.1_Missense_Mutation_p.L104I	NM_019851	NP_062825	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	138					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			lung(1)	1				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		GCTCCCTAAAGATGCATTCGG	0.333													45	215					2.77807e-22	2.96198e-22	1	0	T	16850803	T	T	16850803	2	4	36	1	0	0	0	0	0	0	0	1	5881	932	33	2		2	FGF20	8	16850803	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3493937	16850803	129513219	459	7259											
NPM2	10361	broad.mit.edu	37	chr8	21891774	21891774	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggtgccccagaagcaggcGagcgtggctaaggtggggga	8	5	19	9	2	0	1	0	0	0	1	0	3	0	2	2	6	3	2	2	6	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:21891774G>A	uc003xab.2	+	6	1177	c.519G>A	c.(517-519)GCG>GCA	p.A173A	NPM2_uc003xac.2_Silent_p.A173A|NPM2_uc003xad.2_Silent_p.A173A|NPM2_uc003xae.2_Silent_p.A173A|NPM2_uc003xaf.2_Intron	NM_182795	NP_877724	Q86SE8	NPM2_HUMAN	nucleoplasmin 2	173					chromatin remodeling|embryo development|oocyte differentiation|positive regulation of meiosis|regulation of exit from mitosis|single fertilization	cytoplasmic chromatin|nuclear chromatin	histone binding|nucleic acid binding				0				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		AGAAGCAGGCGAGCGTGGCTA	0.493													5	66					0	0	0	0	A	21891774	A	A	21891774	2	1	36	1	0	0	0	0	0	0	0	1	10642	1045	37	1		1	NPM2	8	21891774	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5040971	21891774	124472248	460	7260											
BNIP3L	665	broad.mit.edu	37	chr8	26238784	26238784	+	5'Flank	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctataacaaagcaaaggctCttctgaagtttctctctttc	11	15	5	10	0	5	1	0	1	5	0	7	1	5	1	0	1	2	3	0	1	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:26238784C>G	uc003xex.1	+						uc003xew.2_RNA|BNIP3L_uc010luh.1_5'Flank|BNIP3L_uc010lui.1_5'Flank	NM_004331	NP_004322	O60238	BNI3L_HUMAN	BCL2/adenovirus E1B 19kD-interacting protein						apoptosis|defense response to virus|induction of apoptosis|interspecies interaction between organisms|mitochondrial protein catabolic process|negative regulation of survival gene product expression	endoplasmic reticulum|integral to membrane|mitochondrial outer membrane|nuclear envelope	lamin binding|protein heterodimerization activity|protein homodimerization activity				0		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0019)|Epithelial(17;1.59e-12)|all cancers(2;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(2;2.57e-08)|Colorectal(74;0.135)		AGCAAAGGCTCTTCTGAAGTT	0.393													13	28					0	0	0	0	G	26238784	G	G	26238784	1	3	36	0	1	0	0	0	0	0	0	0	1482	928	32	2		2	BNIP3L	8	26238784	5'Flank	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4347010	26238784	120125238	461	7261											
FBXO16	157574	broad.mit.edu	37	chr8	28321304	28321304	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaacaggcctgtgaggattCttcttctttgagagtctgtc	7	14	10	10	0	4	2	0	2	4	1	5	4	4	3	2	2	1	0	2	2	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:28321304C>G	uc003xgu.2	-	4	265	c.167G>C	c.(166-168)AGA>ACA	p.R56T	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Missense_Mutation_p.R43T|FBXO16_uc003xgw.2_Missense_Mutation_p.R43T	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	56										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		TGTGAGGATTCTTCTTCTTTG	0.438													20	69					0	0	0	0	G	28321304	G	G	28321304	3	3	36	1	0	0	0	0	1	0	0	0	5761	913	32	2	735	2	FBXO16	8	28321304	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2082520	28321304	118042718	462	7262											
STAR	6770	broad.mit.edu	37	chr8	38005783	38005783	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caaggccttctgcatggcctCctccccctgctggagatagg	6	9	11	15	0	1	1	0	0	1	1	3	2	3	1	5	4	2	2	5	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:38005783C>T	uc003xkv.1	-	3	505	c.241G>A	c.(241-243)GAG>AAG	p.E81K	STAR_uc010lwc.1_Missense_Mutation_p.E43K	NM_001007243	NP_001007244	P49675	STAR_HUMAN	steroidogenic acute regulatory protein isoform	81	START.				C21-steroid hormone biosynthetic process	mitochondrial intermembrane space	cholesterol transporter activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.0151)|Lung NSC(58;0.0295)		READ - Rectum adenocarcinoma(644;0.188)		TGCATGGCCTCCTCCCCCTGC	0.567													23	39					0	0	0	0	T	38005783	T	T	38005783	3	4	36	1	0	0	0	0	1	0	0	0	15320	864	30	2	636	2	STAR	8	38005783	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	9684479	38005783	108358239	463	7263											
CHRNA6	8973	broad.mit.edu	37	chr8	42611623	42611623	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gattaatcgtgtaaaacatcGgcaatcttctaatgtagaaa	16	12	7	6	2	2	1	0	0	2	1	4	2	2	1	0	1	1	3	0	1	7	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:42611623G>A	uc003xpj.2	-	5	765	c.719C>T	c.(718-720)CCG>CTG	p.P240L	CHRNA6_uc011lcw.1_Missense_Mutation_p.P225L	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	240	Helical; (Potential).					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GTAAAACATCGGCAATCTTCT	0.368													28	56					0	0	0	0	A	42611623	A	A	42611623	3	1	36	1	0	0	0	0	1	0	0	0	3402	1116	39	1	773	1	CHRNA6	8	42611623	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4605840	42611623	103752399	464	7264											
POTEA	340441	broad.mit.edu	37	chr8	43173738	43173738	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatgaaaatcagcaatttcCtaacacagagattgaagagt	17	9	8	7	0	1	4	1	2	0	2	2	5	2	4	1	0	2	2	1	0	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:43173738C>T	uc003xpz.1	+	9	1203	c.1160C>T	c.(1159-1161)CCT>CTT	p.P387L	POTEA_uc003xqa.1_Missense_Mutation_p.P341L	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	387										ovary(1)	1						CAGCAATTTCCTAACACAGAG	0.393													18	72					0	0	0	0	T	43173738	T	T	43173738	3	4	36	1	0	0	0	0	1	0	0	0	12316	681	24	4	1194	4	POTEA	8	43173738	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	562115	43173738	103190284	465	7265											
PRKDC	5591	broad.mit.edu	37	chr8	48776002	48776002	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catttccttctgtaatacacGagccatggaaaacttgatta	13	13	6	9	1	1	1	0	1	1	0	2	3	2	2	2	1	3	1	2	1	5	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:48776002G>A	uc003xqi.2	-	43	5765	c.5708C>T	c.(5707-5709)TCG>TTG	p.S1903L	PRKDC_uc003xqj.2_Missense_Mutation_p.S1903L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1903					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGTAATACACGAGCCATGGAA	0.313								NHEJ					44	170					0	0	0	0	A	48776002	A	A	48776002	3	1	36	1	0	0	0	0	1	0	0	0	12583	1059	37	1	6858	1	PRKDC	8	48776002	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5602264	48776002	97588020	466	7266											
RP1	6101	broad.mit.edu	37	chr8	55538105	55538105	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgttatagaaattacaagtCagaagatgttagagatgtca	16	12	10	3	0	2	4	2	0	0	4	2	5	2	4	0	0	1	2	0	0	7	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:55538105C>G	uc003xsd.1	+	4	1811	c.1663C>G	c.(1663-1665)CAG>GAG	p.Q555E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	555					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AATTACAAGTCAGAAGATGTT	0.338													20	103					0	0	0	0	G	55538105	G	G	55538105	3	3	36	1	0	0	0	0	1	0	0	0	13597	827	29	2	1673	2	RP1	8	55538105	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6762103	55538105	90825917	467	7267											
XKR4	114786	broad.mit.edu	37	chr8	56015534	56015534	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctctgtcggtgcaagtgttCagcttccgctggtttgtgca	4	15	12	10	2	2	0	1	0	1	0	5	0	3	0	1	2	3	6	1	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:56015534C>T	uc003xsf.2	+	1	518	c.486C>T	c.(484-486)TTC>TTT	p.F162F		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	162	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TGCAAGTGTTCAGCTTCCGCT	0.652													24	63					0	0	0	0	T	56015534	T	T	56015534	2	4	36	1	0	0	0	0	0	0	0	1	17501	825	29	2		2	XKR4	8	56015534	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	477429	56015534	90348488	468	7268											
VCPIP1	80124	broad.mit.edu	37	chr8	67547415	67547415	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atagcccatgtgagggacttGattccctacttcttgtagta	9	14	9	9	0	1	2	0	2	1	0	2	3	2	3	2	1	2	2	2	1	4	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:67547415G>C	uc003xwn.2	-	3	3249	c.2990C>G	c.(2989-2991)TCA>TGA	p.S997*		NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	997					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TGAGGGACTTGATTCCCTACT	0.438													76	280					0	0	0	0	C	67547415	C	C	67547415	4	2	36	1	0	0	0	0	0	1	0	0	17209	1294	45	2	682	2	VCPIP1	8	67547415	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	11531881	67547415	78816607	469	7269											
SULF1	23213	broad.mit.edu	37	chr8	70550802	70550802	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgtttgcgtacagttaatGagacgcataattttcttttc	9	17	9	6	2	1	1	0	1	1	1	2	2	1	1	0	1	2	4	0	1	3	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:70550802G>A	uc010lza.1	+	20	3067	c.2350G>A	c.(2350-2352)GAG>AAG	p.E784K	SULF1_uc003xyd.2_Missense_Mutation_p.E784K|SULF1_uc003xye.2_Missense_Mutation_p.E784K|SULF1_uc003xyf.2_Missense_Mutation_p.E784K|SULF1_uc003xyg.2_Missense_Mutation_p.E784K|SULF1_uc003xyh.1_RNA|SULF1_uc003xyi.1_Intron|SULF1_uc003xyj.1_5'UTR	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	784					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TACAGTTAATGAGACGCATAA	0.343													40	171					0	0	0	0	A	70550802	A	A	70550802	3	1	36	1	0	0	0	0	1	0	0	0	15436	1291	45	2	2412	2	SULF1	8	70550802	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3003387	70550802	75813220	470	7270											
TRPA1	8989	broad.mit.edu	37	chr8	72942205	72942205	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgccaactgccaaaccaatCtgaagtatgacacaaaatta	17	8	5	11	1	1	2	0	2	1	0	2	2	1	2	3	0	3	1	3	0	8	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:72942205C>G	uc003xza.2	-	24	3044	c.2869_splice	c.e24-1	p.I957_splice	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1							integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CCAAACCAATCTGAAGTATGA	0.299													22	75					0	0	0	0	G	72942205	G	G	72942205	5	3	36	1	0	0	0	0	0	0	1	0	16644	927	32	2	507	2	TRPA1	8	72942205	Splice_Site	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2391403	72942205	73421817	471	7271											
TRPA1	8989	broad.mit.edu	37	chr8	72981315	72981315	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagaggagccatcatgttGaagtttcggagatttgggtt	9	13	15	4	1	1	3	1	1	0	2	2	6	1	4	1	4	1	3	1	4	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:72981315G>A	uc003xza.2	-	3	562	c.387C>T	c.(385-387)TTC>TTT	p.F129F		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	129	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CCATCATGTTGAAGTTTCGGA	0.478													22	434					0	0	0	0	A	72981315	A	A	72981315	2	1	36	1	0	0	0	0	0	0	0	1	16644	1281	45	2		2	TRPA1	8	72981315	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	39110	72981315	73382707	472	7272											
ATP6V0D2	245972	broad.mit.edu	37	chr8	87151798	87151798	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgggccgtttcacagaaatgGaagctgtcaacattgcagag	12	9	12	8	1	2	2	2	0	0	2	2	3	2	3	1	2	3	3	1	2	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:87151798G>C	uc003ydp.1	+	3	484	c.415G>C	c.(415-417)GAA>CAA	p.E139Q		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	139					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0						CACAGAAATGGAAGCTGTCAA	0.428													38	226					0	0	0	0	C	87151798	C	C	87151798	3	2	36	1	0	0	0	0	1	0	0	0	1176	1175	41	2	425	2	ATP6V0D2	8	87151798	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	14170483	87151798	59212224	473	7273											
SLC7A13	157724	broad.mit.edu	37	chr8	87242048	87242048	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaagccaagtcacttctttCacaccacgagaagtcagaat	14	9	7	11	1	4	3	3	1	1	2	4	4	4	3	2	0	1	0	2	0	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:87242048C>G	uc003ydq.1	-	1	557	c.459G>C	c.(457-459)GTG>GTC	p.V153V	SLC7A13_uc003ydr.1_Silent_p.V153V	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	153	Cytoplasmic (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						TCACTTCTTTCACACCACGAG	0.453													28	114					0	0	0	0	G	87242048	G	G	87242048	2	3	36	1	0	0	0	0	0	0	0	1	14759	813	29	2		2	SLC7A13	8	87242048	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	90250	87242048	59121974	474	7274											
CNGB3	54714	broad.mit.edu	37	chr8	87616352	87616352	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacaccgacccagctttcaGagtaaccagaactttagtac	15	8	6	12	1	1	2	1	0	0	2	1	3	1	2	3	0	5	3	3	0	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:87616352G>C	uc003ydx.2	-	15	1796	c.1750C>G	c.(1750-1752)CTG>GTG	p.L584V	CNGB3_uc010maj.2_Missense_Mutation_p.L446V	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	584	Cytoplasmic (Potential).|cGMP (By similarity).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						CCAGCTTTCAGAGTAACCAGA	0.368													24	101					0	0	0	0	C	87616352	C	C	87616352	3	2	36	1	0	0	0	0	1	0	0	0	3616	933	33	2	695	2	CNGB3	8	87616352	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	374304	87616352	58747670	475	7275											
NBN	4683	broad.mit.edu	37	chr8	90965508	90965508	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctggtactgcttcatcactGaaagtgtcatttgtttctat	8	18	7	8	0	5	1	3	1	2	0	5	1	5	1	0	1	2	3	0	1	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:90965508G>A	uc003yej.1	-	11	1919	c.1809C>T	c.(1807-1809)TTC>TTT	p.F603F	NBN_uc003yei.1_Silent_p.F521F|NBN_uc011lgb.1_Silent_p.F603F	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	603					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			CTTCATCACTGAAAGTGTCAT	0.343								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				67	262					0	0	0	0	A	90965508	A	A	90965508	2	1	36	1	0	0	0	0	0	0	0	1	10244	1281	45	2		2	NBN	8	90965508	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3349156	90965508	55398514	476	7276											
TMEM55A	55529	broad.mit.edu	37	chr8	92032432	92032432	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgagatgtgtccttacaaatGagaagacaattacaagggca	16	8	10	7	1	0	3	0	1	0	3	1	5	1	3	1	1	2	1	1	1	6	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:92032432G>A	uc003yes.2	-	3	541	c.315C>T	c.(313-315)CTC>CTT	p.L105L		NM_018710	NP_061180	Q8N4L2	TM55A_HUMAN	transmembrane protein 55A	105						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0			BRCA - Breast invasive adenocarcinoma(11;0.033)			CCTTACAAATGAGAAGACAAT	0.343													30	151					0	0	0	0	A	92032432	A	A	92032432	2	1	36	1	0	0	0	0	0	0	0	1	16247	1277	45	2		2	TMEM55A	8	92032432	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1066924	92032432	54331590	477	7277											
TMEM67	91147	broad.mit.edu	37	chr8	94767324	94767324	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctttgatatctccgccctctCgtgtgttccttgtggagcta	4	16	9	12	2	2	1	0	1	2	0	5	2	3	2	3	1	1	2	3	1	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:94767324C>G	uc011lgk.1	+	1	253	c.182C>G	c.(181-183)TCG>TGG	p.S61W	TMEM67_uc010mau.2_Missense_Mutation_p.S61W|TMEM67_uc010mav.2_Missense_Mutation_p.S61W|TMEM67_uc010mat.1_5'UTR|TMEM67_uc010maw.2_Missense_Mutation_p.S61W|TMEM67_uc003yga.3_5'UTR	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	61					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			TCCGCCCTCTCGTGTGTTCCT	0.562													57	263					0	0	0	0	G	94767324	G	G	94767324	3	3	36	1	0	0	0	0	1	0	0	0	16262	893	31	3	184	3	TMEM67	8	94767324	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2734892	94767324	51596698	478	7278											
ESRP1	54845	broad.mit.edu	37	chr8	95683700	95683700	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgctgaatcgattctcctCggcccctctcattccacttc	5	13	7	16	2	2	1	1	1	2	0	8	2	3	1	4	2	1	1	4	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:95683700C>T	uc003ygq.3	+	11	1436	c.1253C>T	c.(1252-1254)TCG>TTG	p.S418L	ESRP1_uc003ygr.3_Missense_Mutation_p.S418L|ESRP1_uc003ygs.3_Missense_Mutation_p.S418L|ESRP1_uc003ygt.3_Missense_Mutation_p.S418L|ESRP1_uc003ygu.3_Missense_Mutation_p.S418L|ESRP1_uc003ygv.2_Missense_Mutation_p.S258L|ESRP1_uc003ygw.2_Missense_Mutation_p.S258L	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	418					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						CGATTCTCCTCGGCCCCTCTC	0.428													30	73					0	0	0	0	T	95683700	T	T	95683700	3	4	36	1	0	0	0	0	1	0	0	0	5282	893	31	1	1295	1	ESRP1	8	95683700	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	916376	95683700	50680322	479	7279											
PTDSS1	9791	broad.mit.edu	37	chr8	97316403	97316403	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtaccttttcatgatcatCtggcaggtattttttcagat	8	18	8	7	0	4	2	3	1	1	1	4	2	4	2	1	2	1	3	1	2	2	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:97316403C>G	uc003yht.1	+	7	990	c.888C>G	c.(886-888)ATC>ATG	p.I296M	PTDSS1_uc003yhu.1_Missense_Mutation_p.I150M	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	296	Helical; (Potential).				phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TCATGATCATCTGGCAGGTAT	0.378													4	388					0	0	0	0	G	97316403	G	G	97316403	3	3	36	1	0	0	0	0	1	0	0	0	12798	903	32	2	914	2	PTDSS1	8	97316403	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1632703	97316403	49047619	480	7280											
VPS13B	157680	broad.mit.edu	37	chr8	100654191	100654191	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcacagtggtgccagtcaGcatcgcattgcccgtccctc	7	8	10	16	2	1	0	1	0	0	0	4	0	2	0	3	1	4	3	3	1	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:100654191G>T	uc003yiv.2	+	34	5559	c.5448G>T	c.(5446-5448)CAG>CAT	p.Q1816H	VPS13B_uc003yiw.2_Missense_Mutation_p.Q1791H	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1816					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GTGCCAGTCAGCATCGCATTG	0.413													25	152					1.68575e-08	1.74713e-08	1	0	T	100654191	T	T	100654191	3	4	36	1	0	0	0	0	1	0	0	0	17258	962	34	4	5772	4	VPS13B	8	100654191	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3337788	100654191	45709831	481	7281											
UBR5	51366	broad.mit.edu	37	chr8	103289202	103289202	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagggtcttagcaaatacctGaaagatgtgagaggtggccc	13	8	13	7	0	1	3	0	2	1	2	1	4	1	3	2	3	2	1	2	3	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:103289202G>A	uc003ykr.1	-	45	6540	c.6507C>T	c.(6505-6507)TTC>TTT	p.F2169F	UBR5_uc003yks.1_Silent_p.F2169F	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2169					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GCAAATACCTGAAAGATGTGA	0.383													36	129					0	0	0	0	A	103289202	A	A	103289202	2	1	36	1	0	0	0	0	0	0	0	1	16973	1281	45	2		2	UBR5	8	103289202	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2635011	103289202	43074820	482	7282											
UBR5	51366	broad.mit.edu	37	chr8	103323529	103323529	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcaatactcaaattacctCtacagccatgatgataacag	15	12	4	10	0	3	2	2	2	1	0	3	2	3	2	2	0	5	0	2	0	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:103323529C>G	uc003ykr.1	-	20	2647	c.2614G>C	c.(2614-2616)GAG>CAG	p.E872Q	UBR5_uc003yks.1_Missense_Mutation_p.E872Q	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	872					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CAAATTACCTCTACAGCCATG	0.333													36	154					0	0	0	0	G	103323529	G	G	103323529	3	3	36	1	0	0	0	0	1	0	0	0	16973	922	32	2	5945	2	UBR5	8	103323529	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	34327	103323529	43040493	483	7283											
PKHD1L1	93035	broad.mit.edu	37	chr8	110397821	110397821	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtctatggaagtaatatTgcactaagctcaaatgggaa	15	11	10	5	0	2	0	1	0	1	0	2	3	2	2	0	2	2	3	0	2	7	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:110397821T>A	uc003yne.2	+	6	635	c.531T>A	c.(529-531)ATT>ATA	p.I177I		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	177	Extracellular (Potential).|IPT/TIG 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GAAGTAATATTGCACTAAGCT	0.294										HNSCC(38;0.096)			12	81					0	0	0	0	A	110397821	A	A	110397821	2	1	36	1	0	0	0	0	0	0	0	1	12027	1800	63	5		5	PKHD1L1	8	110397821	Silent	SNP	T	TCGA-CN-4723-01A-01D-1434-08	7074292	110397821	35966201	484	7284											
PKHD1L1	93035	broad.mit.edu	37	chr8	110476619	110476619	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgagaggaatattatatatGatattaagggaggagcattt	15	14	11	1	0	0	2	0	2	0	1	0	6	0	5	0	3	1	1	0	3	7	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:110476619G>C	uc003yne.2	+	49	7662	c.7558G>C	c.(7558-7560)GAT>CAT	p.D2520H		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2520	PbH1 1.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TATTATATATGATATTAAGGG	0.363										HNSCC(38;0.096)			20	53					0	0	0	0	C	110476619	C	C	110476619	3	2	36	1	0	0	0	0	1	0	0	0	12027	1290	45	2	7752	2	PKHD1L1	8	110476619	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	78798	110476619	35887403	485	7285											
CSMD3	114788	broad.mit.edu	37	chr8	113301749	113301749	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcattaggaggaacgccaGggtgtccacagtcaatcact	11	8	11	11	1	2	0	2	0	0	0	3	2	3	2	2	3	2	1	2	3	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:113301749G>A	uc003ynu.2	-	57	9152	c.8993C>T	c.(8992-8994)CCT>CTT	p.P2998L	CSMD3_uc003yns.2_Missense_Mutation_p.P2200L|CSMD3_uc003ynt.2_Missense_Mutation_p.P2958L|CSMD3_uc011lhx.1_Missense_Mutation_p.P2829L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2998	Sushi 21.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGGAACGCCAGGGTGTCCACA	0.393										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	47					0	0	0	0	A	113301749	A	A	113301749	3	1	36	1	0	0	0	0	1	0	0	0	3963	1000	35	4	2190	4	CSMD3	8	113301749	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2825130	113301749	33062273	486	7286											
CSMD3	114788	broad.mit.edu	37	chr8	113421233	113421233	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaacatcgtggagtgatgtCtggaaaaatacaaactggcc	15	8	10	8	1	1	1	0	1	1	0	2	3	1	3	1	3	3	0	1	3	5	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:113421233C>T	uc003ynu.2	-	33	5583	c.5424G>A	c.(5422-5424)CAG>CAA	p.Q1808Q	CSMD3_uc003yns.2_Intron|CSMD3_uc003ynt.2_Silent_p.Q1768Q|CSMD3_uc011lhx.1_Silent_p.Q1704Q	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1808	Extracellular (Potential).|CUB 10.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGAGTGATGTCTGGAAAAATA	0.408										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			70	180					0	0	0	0	T	113421233	T	T	113421233	2	4	36	1	0	0	0	0	0	0	0	1	3963	912	32	2		2	CSMD3	8	113421233	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	119484	113421233	32942789	487	7287											
CSMD3	114788	broad.mit.edu	37	chr8	114290824	114290824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccactaccatcacttaccttCgtaatataccttaaatccat	13	13	1	14	1	1	0	1	0	0	0	3	0	2	0	5	0	3	1	5	0	7	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:114290824C>T	uc003ynu.2	-	3	670	c.511G>A	c.(511-513)GAA>AAA	p.E171K	CSMD3_uc003ynt.2_Missense_Mutation_p.E131K|CSMD3_uc011lhx.1_Missense_Mutation_p.E171K|CSMD3_uc010mcx.1_Missense_Mutation_p.E171K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	171	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACTTACCTTCGTAATATACC	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	95					0	0	0	0	T	114290824	T	T	114290824	3	4	36	1	0	0	0	0	1	0	0	0	3963	893	31	1	10888	1	CSMD3	8	114290824	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	869591	114290824	32073198	488	7288											
SLC30A8	169026	broad.mit.edu	37	chr8	118184876	118184876	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcagatggaatctccagttGaccaggaccccgactgcctt	9	10	9	13	1	2	2	1	1	1	1	3	5	2	4	5	2	1	1	5	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:118184876G>C	uc003yoh.2	+	8	1296	c.1066G>C	c.(1066-1068)GAC>CAC	p.D356H	SLC30A8_uc010mcz.2_Missense_Mutation_p.D307H|SLC30A8_uc011lia.1_Missense_Mutation_p.D307H|SLC30A8_uc003yog.2_Missense_Mutation_p.D307H	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	356	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			ATCTCCAGTTGACCAGGACCC	0.507													37	232					0	0	0	0	C	118184876	C	C	118184876	3	2	36	1	0	0	0	0	1	0	0	0	14625	1290	45	2	1096	2	SLC30A8	8	118184876	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3894052	118184876	28179146	489	7289											
WDYHV1	55093	broad.mit.edu	37	chr8	124449572	124449572	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atatccctgcattgagactgGaggtgagccaagatgccttc	10	10	11	10	0	0	3	0	2	0	2	2	5	1	4	3	2	3	1	3	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:124449572G>C	uc003yqn.1	+	5	631	c.506G>C	c.(505-507)GGA>GCA	p.G169A	WDYHV1_uc011lij.1_Missense_Mutation_p.G109A|WDYHV1_uc003yqo.1_RNA	NM_018024	NP_060494	Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	169					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			ovary(1)|skin(1)	2						ATTGAGACTGGAGGTGAGCCA	0.458													7	69					0	0	0	0	C	124449572	C	C	124449572	3	2	36	1	0	0	0	0	1	0	0	0	17411	1174	41	2	524	2	WDYHV1	8	124449572	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	6264696	124449572	21914450	490	7290											
FER1L6	654463	broad.mit.edu	37	chr8	125022951	125022951	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggagaaaatggcagacttCctggtaggtgactctgacag	11	9	13	8	0	1	4	0	2	1	2	2	5	2	4	1	4	0	2	1	4	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:125022951C>A	uc003yqw.2	+	14	2024	c.1818C>A	c.(1816-1818)TTC>TTA	p.F606L	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	606	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TGGCAGACTTCCTGGTAGGTG	0.488													9	407					0.000442599	0.000452205	1	0	A	125022951	A	A	125022951	3	1	36	1	0	0	0	0	1	0	0	0	5847	854	30	2	1868	2	FER1L6	8	125022951	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	573379	125022951	21341071	491	7291											
FER1L6	654463	broad.mit.edu	37	chr8	125103812	125103812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggaaaaactatcttcactGaagaggacactggtaactcc	14	9	8	10	0	2	2	1	1	1	1	3	4	3	4	1	3	2	1	1	3	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:125103812G>A	uc003yqw.2	+	34	4746	c.4540G>A	c.(4540-4542)GAA>AAA	p.E1514K	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1514	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TATCTTCACTGAAGAGGACAC	0.403													34	157					0	0	0	0	A	125103812	A	A	125103812	3	1	36	1	0	0	0	0	1	0	0	0	5847	1291	45	2	4670	2	FER1L6	8	125103812	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	80861	125103812	21260210	492	7292											
FER1L6	654463	broad.mit.edu	37	chr8	125131944	125131944	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtacatcatcattgctttCattctcatcatcctcatcat	11	16	2	12	0	7	0	7	0	1	0	9	0	8	0	1	0	2	2	1	0	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:125131944C>G	uc003yqw.2	+	41	5693	c.5487C>G	c.(5485-5487)TTC>TTG	p.F1829L	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1829	Helical; (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			tcattgctttcattctcatca	0.368													62	270					0	0	0	0	G	125131944	G	G	125131944	3	3	36	1	0	0	0	0	1	0	0	0	5847	825	29	2	5645	2	FER1L6	8	125131944	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	28132	125131944	21232078	493	7293											
FAM135B	51059	broad.mit.edu	37	chr8	139190891	139190891	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggacgtgagccaggccagatCcttgcttatctgctcagcga	8	9	12	12	2	2	2	1	1	1	1	3	4	3	3	3	2	4	2	3	2	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:139190891C>G	uc003yuy.2	-	10	1087	c.916G>C	c.(916-918)GAT>CAT	p.D306H	FAM135B_uc003yux.2_Missense_Mutation_p.D207H|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	306										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAGGCCAGATCCTTGCTTATC	0.512										HNSCC(54;0.14)			21	72					0	0	0	0	G	139190891	G	G	139190891	3	3	36	1	0	0	0	0	1	0	0	0	5477	855	30	2	3348	2	FAM135B	8	139190891	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	14058947	139190891	7173131	494	7294											
PTK2	5747	broad.mit.edu	37	chr8	141828403	141828403	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccttgtccgttaggtaactGattccttcttctgggccgat	5	15	9	12	2	2	1	0	1	2	0	4	2	4	1	4	2	1	2	4	2	2	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:141828403G>C	uc003yvu.2	-	10	1070	c.840C>G	c.(838-840)ATC>ATG	p.I280M	PTK2_uc003yvq.2_Translation_Start_Site|PTK2_uc003yvr.2_Missense_Mutation_p.I179M|PTK2_uc003yvs.2_Missense_Mutation_p.I280M|PTK2_uc003yvt.2_Missense_Mutation_p.I302M|PTK2_uc003yvv.2_Missense_Mutation_p.I167M|PTK2_uc011ljr.1_Missense_Mutation_p.I280M	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	280	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TTAGGTAACTGATTCCTTCTT	0.438													43	120					0	0	0	0	C	141828403	C	C	141828403	3	2	36	1	0	0	0	0	1	0	0	0	12825	1280	45	2	2410	2	PTK2	8	141828403	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2637512	141828403	4535619	495	7295											
ARC	23237	broad.mit.edu	37	chr8	143695306	143695306	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacacgtgcatctcgcgcttGacccagcgctccaggttggc	6	8	11	16	4	1	1	0	1	1	0	3	1	2	1	2	2	2	4	2	2	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:143695306G>C	uc003ywn.1	-	1	528	c.327C>G	c.(325-327)GTC>GTG	p.V109V		NM_015193	NP_056008	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated	109					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)	1	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				TCTCGCGCTTGACCCAGCGCT	0.682													6	38					0	0	0	0	C	143695306	C	C	143695306	2	2	36	1	0	0	0	0	0	0	0	1	841	1277	45	2		2	ARC	8	143695306	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1866903	143695306	2668716	496	7296											
PUF60	22827	broad.mit.edu	37	chr8	144899226	144899226	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccttcttgggctccaggaGacccagcgttggagggctgg	5	9	15	12	1	1	1	0	0	1	1	3	3	3	2	3	5	1	3	3	5	0	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:144899226G>C	uc003yzs.2	-	11	1298	c.1234C>G	c.(1234-1236)CTC>GTC	p.L412V	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Missense_Mutation_p.L352V|PUF60_uc003yzt.2_Missense_Mutation_p.L395V|PUF60_uc003yzq.2_Missense_Mutation_p.L369V|PUF60_uc003yzu.1_Missense_Mutation_p.L401V	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	412	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGCTCCAGGAGACCCAGCGTT	0.622													7	35					0	0	0	0	C	144899226	C	C	144899226	3	2	36	1	0	0	0	0	1	0	0	0	12889	942	33	2	453	2	PUF60	8	144899226	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1203920	144899226	1464796	497	7297											
EPPK1	83481	broad.mit.edu	37	chr8	144940991	144940991	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcccgtctggtgtgtgttCtatacatcctcaccagctgg	5	13	11	12	1	3	0	1	0	2	0	4	0	4	0	3	2	3	2	3	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:144940991C>T	uc003zaa.1	-	1	6444	c.6431G>A	c.(6430-6432)AGA>AAA	p.R2144K		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2144						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTGTGTGTTCTATACATCCT	0.507													74	387					0	0	0	0	T	144940991	T	T	144940991	3	4	36	1	0	0	0	0	1	0	0	0	5214	913	32	2	835	2	EPPK1	8	144940991	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	41765	144940991	1423031	498	7298											
EPPK1	83481	broad.mit.edu	37	chr8	144942429	144942435	+	Frame_Shift_Del	DEL	GGAAGAG	-	-																															gaggtccttctgcatggcctGgaagagggagatctgctgcc																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:144942429_144942435delGGAAGAG	uc003zaa.1	-	1	5000_5006	c.4987_4993delCTCTTCC	c.(4987-4995)CTCTTCCAGfs	p.L1663fs		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1663_1665	Plectin 28.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCATGGCCTGGAAGAGGGAGATCTGC	0.647													---	---	---								-	144942435	-	-	144942429	7	5	36	1	0	1	0	1	0	0	0	0	5214	1357	47	0	2273	0	EPPK1	8	144942429	Frame_Shift_Del	DEL	GGAAGAG	TCGA-CN-4723-01A-01D-1434-08	1438	144942429	1421593	499	7299											
ZNF250	58500	broad.mit.edu	37	chr8	146107829	146107829	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attacactcatagggcttctCacctgtgtgaattctcctgt	8	15	7	11	0	3	1	2	1	2	0	5	1	3	1	2	1	1	1	2	1	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:146107829C>G	uc003zeq.3	-	6	871	c.754G>C	c.(754-756)GAG>CAG	p.E252Q	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Missense_Mutation_p.E247Q|ZNF250_uc010mgg.2_Missense_Mutation_p.E247Q	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		TAGGGCTTCTCACCTGTGTGA	0.483													12	76					0	0	0	0	G	146107829	G	G	146107829	3	3	36	1	0	0	0	0	1	0	0	0	17862	835	29	2	932	2	ZNF250	8	146107829	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1165400	146107829	256193	500	7300											
ZNF250	58500	broad.mit.edu	37	chr8	146108151	146108151	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagggtgttttccccagaatCactgtttgctctgaaattaa	11	14	8	8	0	2	2	1	1	1	1	3	2	3	2	2	1	1	3	2	1	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr8:146108151C>T	uc003zeq.3	-	6	549	c.432G>A	c.(430-432)GTG>GTA	p.V144V	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Silent_p.V139V|ZNF250_uc010mgg.2_Silent_p.V139V	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		TCCCCAGAATCACTGTTTGCT	0.398													7	417					0	0	0	0	T	146108151	T	T	146108151	2	4	36	1	0	0	0	0	0	0	0	1	17862	813	29	2		2	ZNF250	8	146108151	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	322	146108151	255871	501	7301											
DOCK8	81704	broad.mit.edu	37	chr9	376246	376246	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctcccattaagtgggctGaaggacataagggagtattt	12	11	11	7	0	0	1	0	1	0	0	2	3	2	3	2	3	0	2	2	3	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:376246G>A	uc003zgf.2	+	19	2258	c.2146G>A	c.(2146-2148)GAA>AAA	p.E716K	DOCK8_uc010mgu.2_Missense_Mutation_p.E18K|DOCK8_uc010mgv.2_Missense_Mutation_p.E648K|DOCK8_uc010mgw.1_Missense_Mutation_p.E18K|DOCK8_uc003zgk.2_Missense_Mutation_p.E174K|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	716					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TAAGTGGGCTGAAGGACATAA	0.378													7	152					0	0	0	0	A	376246	A	A	376246	3	1	36	1	0	0	0	0	1	0	0	0	4715	1291	45	2	2220	2	DOCK8	9	376246	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08		376246	140837185	502	7302											
CDKN2A	1029	broad.mit.edu	37	chr9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcagctccgccactcGggcgctgcccatcatcatga	8	6	10	17	3	2	1	2	1	0	0	4	1	3	1	3	1	4	4	3	1	0	0	rs121913387		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	6					0	0	0	0	A	21971186	A	A	21971186	4	1	36	1	0	0	0	0	0	1	0	0	3176	1125	39	1	306	1	CDKN2A	9	21971186	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	21594940	21971186	119242245	503	7303											
DDX58	23586	broad.mit.edu	37	chr9	32500912	32500912	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgggcccttgttgtttttCtcagcctgaatatactgcac	7	16	8	10	0	1	1	1	1	1	0	2	1	1	1	2	1	3	3	2	1	3	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:32500912C>A	uc003zra.2	-	2	290	c.132G>T	c.(130-132)GAG>GAT	p.E44D	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Intron|DDX58_uc011lnr.1_5'UTR|DDX58_uc010mji.2_5'UTR	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	44	CARD 1.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		TGTTGTTTTTCTCAGCCTGAA	0.438													8	95					0.00307968	0.00312564	1	0	A	32500912	A	A	32500912	3	1	36	1	0	0	0	0	1	0	0	0	4392	912	32	2	2713	2	DDX58	9	32500912	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	10529726	32500912	108712519	504	7304											
NFX1	4799	broad.mit.edu	37	chr9	33366762	33366762	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaagcgcaatgtggtggtcActgccatcaggtaggtcaat	10	9	13	9	2	3	0	3	0	0	0	3	1	3	0	1	4	2	2	1	4	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:33366762A>T	uc003zsq.2	+	22	3236	c.3175A>T	c.(3175-3177)ACT>TCT	p.T1059S	SUGT1P1_uc010mjq.1_Intron|NFX1_uc003zsr.2_Missense_Mutation_p.T1060S	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	1059	R3H.				inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		TGTGGTGGTCACTGCCATCAG	0.458													14	20					0	0	0	0	T	33366762	T	T	33366762	3	4	36	1	0	0	0	0	1	0	0	0	10441	159	6	5	3379	5	NFX1	9	33366762	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	865850	33366762	107846669	505	7305											
C9orf131	138724	broad.mit.edu	37	chr9	35043827	35043827	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctgccagaactccagagaGagagttccctggaagatcca	12	6	10	13	0	0	4	0	0	0	4	3	7	3	5	5	1	2	1	5	1	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:35043827G>C	uc003zvw.2	+	2	1230	c.1201G>C	c.(1201-1203)GAG>CAG	p.E401Q	C9orf131_uc003zvu.2_Missense_Mutation_p.E353Q|C9orf131_uc003zvv.2_Missense_Mutation_p.E328Q|C9orf131_uc003zvx.2_Missense_Mutation_p.E366Q	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	401											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			ACTCCAGAGAGAGAGTTCCCT	0.532													4	153					0	0	0	0	C	35043827	C	C	35043827	3	2	36	1	0	0	0	0	1	0	0	0	2469	943	33	2	1223	2	C9orf131	9	35043827	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1677065	35043827	106169604	506	7306											
PIGO	84720	broad.mit.edu	37	chr9	35092440	35092440	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccacaggtgtcaggagtaGagggcagaatggaaagcctg	12	5	17	7	0	1	2	1	0	0	2	1	4	1	4	2	5	1	2	2	5	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:35092440G>C	uc003zwd.2	-	7	1840	c.1444C>G	c.(1444-1446)CTA>GTA	p.L482V	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Intron|PIGO_uc003zwf.2_Intron|PIGO_uc003zwg.1_Missense_Mutation_p.L45V	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	482	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTCAGGAGTAGAGGGCAGAAT	0.582													3	118					0	0	0	0	C	35092440	C	C	35092440	3	2	36	1	0	0	0	0	1	0	0	0	11949	933	33	2	1845	2	PIGO	9	35092440	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	48613	35092440	106120991	507	7307											
SHB	6461	broad.mit.edu	37	chr9	37974647	37974647	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gctgggatggtgacccggttCcactcccaaggctggtcgta	6	9	14	12	2	0	1	0	1	0	0	3	2	2	2	3	5	0	4	3	5	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:37974647C>G	uc004aax.2	-	3	1594	c.1026G>C	c.(1024-1026)TGG>TGC	p.W342C		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	342	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TGACCCGGTTCCACTCCCAAG	0.657													34	71					0	0	0	0	G	37974647	G	G	37974647	3	3	36	1	0	0	0	0	1	0	0	0	14333	856	30	2	519	2	SHB	9	37974647	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2882207	37974647	103238784	508	7308											
ANKRD20A4	728747	broad.mit.edu	37	chr9	69423576	69423576	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaaacacagtgaaagtgtGaaaacagaaagaaacctaaa	23	4	8	6	0	0	4	0	2	0	2	0	4	0	4	1	0	4	1	1	0	8	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:69423576G>C	uc004afn.2	+	15	1984	c.1872G>C	c.(1870-1872)GTG>GTC	p.V624V	uc010mnx.1_5'Flank	NM_001098805	NP_001092275	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	624	Potential.										0						GTGAAAGTGTGAAAACAGAAA	0.358													25	72					0	0	0	0	C	69423576	C	C	69423576	2	2	36	1	0	0	0	0	0	0	0	1	650	1277	45	2		2	ANKRD20A4	9	69423576	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	31448929	69423576	71789855	509	7309											
PGM5	5239	broad.mit.edu	37	chr9	71094415	71094415	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcccggaagcagagtgTggaggaaattgtccgagatc	10	8	15	8	2	0	2	0	0	0	2	2	6	1	5	2	3	3	2	2	3	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:71094415T>C	uc004agr.2	+	8	1470	c.1241T>C	c.(1240-1242)GTG>GCG	p.V414A		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	414					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						AAGCAGAGTGTGGAGGAAATT	0.522													44	115					0	0	0	0	C	71094415	C	C	71094415	3	2	36	1	0	0	0	0	1	0	0	0	11856	1696	59	5	1271	5	PGM5	9	71094415	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	1670839	71094415	70119016	510	7310											
PIP5K1B	8395	broad.mit.edu	37	chr9	71509489	71509489	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atttcctgcaagacatgcacGaagggttgtattttgatacg	11	13	10	7	2	0	2	0	1	0	1	1	3	1	2	1	1	3	4	1	1	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:71509489G>A	uc004agu.2	+	8	1011	c.706G>A	c.(706-708)GAA>AAA	p.E236K	PIP5K1B_uc011lrq.1_Missense_Mutation_p.E236K|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	236	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		AGACATGCACGAAGGGTTGTA	0.423													44	135					0	0	0	0	A	71509489	A	A	71509489	3	1	36	1	0	0	0	0	1	0	0	0	11995	1059	37	1	724	1	PIP5K1B	9	71509489	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	415074	71509489	69703942	511	7311											
PRKACG	5568	broad.mit.edu	37	chr9	71628520	71628520	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcttcaggtcgcggtggatGaggtcgagcgagtgtaggta	7	9	19	6	4	1	1	1	1	0	0	3	4	1	2	0	6	1	3	0	6	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:71628520G>A	uc004agy.2	-	1	520	c.489C>T	c.(487-489)CTC>CTT	p.L163L		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	163	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						CGCGGTGGATGAGGTCGAGCG	0.627													8	23					0	0	0	0	A	71628520	A	A	71628520	2	1	36	1	0	0	0	0	0	0	0	1	12561	1277	45	2		2	PRKACG	9	71628520	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	119031	71628520	69584911	512	7312											
APBA1	320	broad.mit.edu	37	chr9	72132030	72132030	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgctgttcctcttccacctCggggtgctccaggtcggcct	2	12	11	16	2	1	0	0	0	1	0	6	0	4	0	5	4	2	3	5	4	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:72132030C>T	uc004ahh.2	-	2	373	c.97G>A	c.(97-99)GAG>AAG	p.E33K		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	33					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						TCTTCCACCTCGGGGTGCTCC	0.701													7	3					0	0	0	0	T	72132030	T	T	72132030	3	4	36	1	0	0	0	0	1	0	0	0	756	893	31	1	2464	1	APBA1	9	72132030	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	503510	72132030	69081401	513	7313											
TMEM2	23670	broad.mit.edu	37	chr9	74365160	74365160	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtaaatttggctgaagcttGactctttggaggaggagggg	9	11	17	4	0	1	2	0	2	1	0	1	5	1	5	0	7	1	3	0	7	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:74365160G>A	uc011lsa.1	-	2	670	c.130C>T	c.(130-132)CAA>TAA	p.Q44*	TMEM2_uc010mos.2_Nonsense_Mutation_p.Q44*|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	44						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		GCTGAAGCTTGACTCTTTGGA	0.507													30	109					0	0	0	0	A	74365160	A	A	74365160	4	1	36	1	0	0	0	0	0	1	0	0	16187	1299	45	2	4113	2	TMEM2	9	74365160	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2233130	74365160	66848271	514	7314											
TMC1	117531	broad.mit.edu	37	chr9	75435903	75435903	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagatcaaataacttctacCtgggcatgctactgctcatc	11	11	6	13	0	3	1	2	0	1	1	4	1	3	1	2	1	5	3	2	1	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:75435903C>T	uc004aiz.1	+	20	2449	c.1909C>T	c.(1909-1911)CTG>TTG	p.L637L	TMC1_uc010moz.1_Silent_p.L595L|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Silent_p.L491L|TMC1_uc010mpa.1_Silent_p.L491L	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	637	Helical; (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						TAACTTCTACCTGGGCATGCT	0.493													107	249					0	0	0	0	T	75435903	T	T	75435903	2	4	36	1	0	0	0	0	0	0	0	1	16050	680	24	4		4	TMC1	9	75435903	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1070743	75435903	65777528	515	7315											
VPS13A	23230	broad.mit.edu	37	chr9	79834959	79834959	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaaaataaacttggaaattGagttacataacatagcaatt	19	11	5	6	0	0	1	0	1	0	0	0	2	0	2	1	1	4	2	1	1	9	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:79834959G>C	uc004akr.2	+	11	1104	c.844G>C	c.(844-846)GAG>CAG	p.E282Q	VPS13A_uc004akp.3_Missense_Mutation_p.E282Q|VPS13A_uc004akq.3_Missense_Mutation_p.E282Q|VPS13A_uc004aks.2_Missense_Mutation_p.E282Q	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	282					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						CTTGGAAATTGAGTTACATAA	0.294													37	85					0	0	0	0	C	79834959	C	C	79834959	3	2	36	1	0	0	0	0	1	0	0	0	17257	1291	45	2	886	2	VPS13A	9	79834959	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4399056	79834959	61378472	516	7316											
TLE4	7091	broad.mit.edu	37	chr9	82323642	82323642	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctccacaacatctcccctCagatgagcgcagctgctgcc	8	7	9	17	1	2	2	1	1	1	1	4	2	3	2	4	1	5	4	4	1	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:82323642C>G	uc004ald.2	+	14	2128	c.1279C>G	c.(1279-1281)CAG>GAG	p.Q427E	TLE4_uc004alc.2_Missense_Mutation_p.Q402E|TLE4_uc010mpr.2_Missense_Mutation_p.Q281E|TLE4_uc004ale.2_Missense_Mutation_p.Q39E|TLE4_uc011lsq.1_Missense_Mutation_p.Q370E|TLE4_uc010mps.2_Missense_Mutation_p.Q326E|TLE4_uc004alf.2_Missense_Mutation_p.Q341E	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CATCTCCCCTCAGATGAGCGC	0.458													19	41					0	0	0	0	G	82323642	G	G	82323642	3	3	36	1	0	0	0	0	1	0	0	0	16007	827	29	2	1254	2	TLE4	9	82323642	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2488683	82323642	58889789	517	7317											
TLE1	7088	broad.mit.edu	37	chr9	84205745	84205745	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tagtgtctggttgtgcagatCccacacagcgatgttgccgt	7	12	12	10	2	1	1	0	0	1	1	2	2	2	1	2	1	3	3	2	1	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:84205745C>G	uc004aly.2	-	16	2245	c.1804G>C	c.(1804-1806)GAT>CAT	p.D602H	TLE1_uc004alz.2_Missense_Mutation_p.D612H|TLE1_uc011lsr.1_Missense_Mutation_p.D587H|TLE1_uc004ama.1_Missense_Mutation_p.D601H	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	602	WD 3.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						TTGTGCAGATCCCACACAGCG	0.597													46	130					0	0	0	0	G	84205745	G	G	84205745	3	3	36	1	0	0	0	0	1	0	0	0	16004	855	30	2	528	2	TLE1	9	84205745	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1882103	84205745	57007686	518	7318											
FLJ46321	389763	broad.mit.edu	37	chr9	84605884	84605884	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcttcggcttctgcgactGagtcatcgttcactctggct	4	15	9	13	3	5	1	2	1	3	0	7	2	5	1	0	2	1	3	0	2	0	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:84605884G>C	uc004amn.2	+	4	546	c.499G>C	c.(499-501)GAG>CAG	p.E167Q		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	167						integral to membrane					0						TTCTGCGACTGAGTCATCGTT	0.552													27	81					0	0	0	0	C	84605884	C	C	84605884	3	2	36	1	0	0	0	0	1	0	0	0	5964	1291	45	2	513	2	FLJ46321	9	84605884	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	400139	84605884	56607547	519	7319											
DAPK1	1612	broad.mit.edu	37	chr9	90321338	90321338	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctgcaccgctcctgggctGatgaggaggacgaggtgatg	8	7	16	10	2	0	3	0	3	0	0	1	6	1	5	3	4	1	3	3	4	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:90321338G>A	uc004apc.2	+	26	3490	c.3352G>A	c.(3352-3354)GAT>AAT	p.D1118N	DAPK1_uc004apd.2_Missense_Mutation_p.D1118N|DAPK1_uc011ltg.1_Missense_Mutation_p.D1052N|DAPK1_uc011lth.1_Missense_Mutation_p.D855N|DAPK1_uc004apg.2_Missense_Mutation_p.D95N	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	1118					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CTCCTGGGCTGATGAGGAGGA	0.617									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				10	33					0	0	0	0	A	90321338	A	A	90321338	3	1	36	1	0	0	0	0	1	0	0	0	4252	1290	45	2	3450	2	DAPK1	9	90321338	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5715454	90321338	50892093	520	7320											
C9orf47	286223	broad.mit.edu	37	chr9	91606129	91606129	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccggcctgggaacaggggccGaagggcgagccggaccctag	8	2	18	13	4	0	0	0	0	0	0	0	4	0	2	5	6	2	0	5	6	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:91606129G>A	uc004aqd.2	+	1	352	c.219G>A	c.(217-219)CCG>CCA	p.P73P	S1PR3_uc004aqe.2_5'Flank|C9orf47_uc004aqc.1_Intron	NM_001001938	NP_001001938	Q6ZRZ4	CI047_HUMAN	hypothetical protein LOC286223 isoform 1	73						extracellular region					0						AACAGGGGCCGAAGGGCGAGC	0.468													7	7					0	0	0	0	A	91606129	A	A	91606129	2	1	36	1	0	0	0	0	0	0	0	1	2497	1045	37	1		1	C9orf47	9	91606129	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1284791	91606129	49607302	521	7321											
BICD2	23299	broad.mit.edu	37	chr9	95482755	95482755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaagccattgaccagggcctCggcatcgttgttgggctcgg	7	9	14	11	3	0	1	0	1	0	0	3	1	0	1	3	4	1	4	3	4	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:95482755C>T	uc004aso.1	-	4	946	c.889G>A	c.(889-891)GAG>AAG	p.E297K	BICD2_uc004asp.1_Missense_Mutation_p.E297K	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	297					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						ACCAGGGCCTCGGCATCGTTG	0.612													44	89					0	0	0	0	T	95482755	T	T	95482755	3	4	36	1	0	0	0	0	1	0	0	0	1432	893	31	1	1704	1	BICD2	9	95482755	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3876626	95482755	45730676	522	7322											
WNK2	65268	broad.mit.edu	37	chr9	96055302	96055302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggccttctcgggccggctCgctgggccccgagacaccca	5	5	14	17	4	1	1	0	0	1	1	3	3	1	1	5	4	0	2	5	4	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:96055302C>T	uc004ati.1	+	23	5666	c.5666C>T	c.(5665-5667)TCG>TTG	p.S1889L	WNK2_uc011lud.1_Missense_Mutation_p.S1852L|WNK2_uc004atj.2_Missense_Mutation_p.S1852L|WNK2_uc004atk.2_Missense_Mutation_p.S1489L|WNK2_uc004atl.1_Missense_Mutation_p.S446L	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1889					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CGGGCCGGCTCGCTGGGCCCC	0.652													19	28					0	0	0	0	T	96055302	T	T	96055302	3	4	36	1	0	0	0	0	1	0	0	0	17446	893	31	1	5641	1	WNK2	9	96055302	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	572547	96055302	45158129	523	7323											
ALDOB	229	broad.mit.edu	37	chr9	104192167	104192167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttgatggaactgtccacaGagaagaggatttctcggaac	12	9	13	7	1	1	3	0	1	1	2	3	7	2	6	1	4	2	1	1	4	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:104192167G>A	uc004bbk.2	-	3	276	c.194C>T	c.(193-195)TCT>TTT	p.S65F		NM_000035	NP_000026	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	65					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				ACTGTCCACAGAGAAGAGGAT	0.547													73	196					0	0	0	0	A	104192167	A	A	104192167	3	1	36	1	0	0	0	0	1	0	0	0	508	942	33	2	928	2	ALDOB	9	104192167	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	8136865	104192167	37021264	524	7324											
ABCA1	19	broad.mit.edu	37	chr9	107578492	107578492	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagagccggtcatcaatctCatgaaagagttccacaaagg	14	8	10	9	1	3	3	3	2	1	2	5	4	4	3	2	2	1	1	2	2	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:107578492C>T	uc004bcl.2	-	25	3983	c.3670G>A	c.(3670-3672)GAG>AAG	p.E1224K		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1224					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TCATCAATCTCATGAAAGAGT	0.493													100	252					0	0	0	0	T	107578492	T	T	107578492	3	4	36	1	0	0	0	0	1	0	0	0	28	835	29	2	3219	2	ABCA1	9	107578492	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3386325	107578492	33634939	525	7325											
ZNF462	58499	broad.mit.edu	37	chr9	109691062	109691062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccccctcgagcccgagatGaccactgaagtgagcccttc	8	7	10	16	2	0	4	0	3	0	1	3	6	1	4	5	0	2	0	5	0	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:109691062G>A	uc004bcz.2	+	3	5158	c.4869G>A	c.(4867-4869)ATG>ATA	p.M1623I	ZNF462_uc010mto.2_Missense_Mutation_p.M1471I|ZNF462_uc004bda.2_Missense_Mutation_p.M1471I	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1623					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						AGCCCGAGATGACCACTGAAG	0.547													34	131					0	0	0	0	A	109691062	A	A	109691062	3	1	36	1	0	0	0	0	1	0	0	0	17993	1290	45	2	4875	2	ZNF462	9	109691062	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2112570	109691062	31522369	526	7326											
SVEP1	79987	broad.mit.edu	37	chr9	113168843	113168843	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccattgacagttccatattCaattactggtgtggaacatc	11	13	7	10	0	1	1	1	1	0	0	3	2	2	2	2	2	2	1	2	2	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:113168843C>G	uc010mtz.2	-	38	9374	c.9037G>C	c.(9037-9039)GAA>CAA	p.E3013Q	SVEP1_uc010mty.2_Missense_Mutation_p.E939Q	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3013	Sushi 27.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GTTCCATATTCAATTACTGGT	0.488													11	40					0	0	0	0	G	113168843	G	G	113168843	3	3	36	1	0	0	0	0	1	0	0	0	15486	835	29	2	1722	2	SVEP1	9	113168843	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3477781	113168843	28044588	527	7327											
ZNF483	158399	broad.mit.edu	37	chr9	114304423	114304423	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gataatctttattagaagatCaactctttctaggagaaaaa	17	13	6	5	0	4	3	1	0	3	3	4	5	4	3	0	1	1	0	0	1	8	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:114304423C>G	uc004bff.2	+	6	1432	c.1208C>G	c.(1207-1209)TCA>TGA	p.S403*	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	403					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						ATTAGAAGATCAACTCTTTCT	0.393													71	156					0	0	0	0	G	114304423	G	G	114304423	4	3	36	1	0	0	0	0	0	1	0	0	18003	838	29	2	1226	2	ZNF483	9	114304423	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1135580	114304423	26909008	528	7328											
SUSD1	64420	broad.mit.edu	37	chr9	114886646	114886646	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacatagcgagccacaccGcccagcctggagctgtgatt	10	6	11	14	2	0	2	0	1	0	1	0	4	0	3	4	1	4	1	4	1	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:114886646G>A	uc004bfu.2	-	6	818	c.777C>T	c.(775-777)GGC>GGT	p.G259G	SUSD1_uc010mui.2_Silent_p.G259G|SUSD1_uc010muj.2_Silent_p.G259G	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	259	Sushi 2.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						GAGCCACACCGCCCAGCCTGG	0.517													19	69					0	0	0	0	A	114886646	A	A	114886646	2	1	36	1	0	0	0	0	0	0	0	1	15473	1074	38	1		1	SUSD1	9	114886646	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	582223	114886646	26326785	529	7329											
SNX30	401548	broad.mit.edu	37	chr9	115567235	115567235	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagacttacatcacctatagGatcaccaccaaagtaggtcc	14	8	7	12	0	2	1	2	0	0	1	3	3	3	2	4	2	1	1	4	2	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:115567235G>A	uc004bgj.3	+	2	484	c.336G>A	c.(334-336)AGG>AGA	p.R112R		NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	112	PX.				cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						TCACCTATAGGATCACCACCA	0.453													4	234					0	0	0	0	A	115567235	A	A	115567235	2	1	36	1	0	0	0	0	0	0	0	1	14964	1165	41	2		2	SNX30	9	115567235	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	680589	115567235	25646196	530	7330											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123173693	123173693	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttctgcttcctcaagaaatGaatttctgatgttagagaac	12	14	8	7	0	3	4	1	2	2	2	4	5	4	4	1	0	2	3	1	0	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:123173693G>C	uc004bkf.2	-	29	4538	c.4357C>G	c.(4357-4359)CAT>GAT	p.H1453D	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.H462D|CDK5RAP2_uc004bke.2_Missense_Mutation_p.H738D|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.H1453D|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.H718D|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.H718D|CDK5RAP2_uc011lya.1_Missense_Mutation_p.H718D|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.H1223D|CDK5RAP2_uc004bki.2_Missense_Mutation_p.H1220D	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1453					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CTCAAGAAATGAATTTCTGAT	0.398													6	206					0	0	0	0	C	123173693	C	C	123173693	3	2	36	1	0	0	0	0	1	0	0	0	3161	1290	45	2	1364	2	CDK5RAP2	9	123173693	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	7606458	123173693	18039738	531	7331											
RC3H2	54542	broad.mit.edu	37	chr9	125642045	125642045	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtacttacctgaggggtctCatggccttttctactataat	8	16	8	9	0	2	1	1	1	2	0	3	1	2	1	2	3	3	1	2	3	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:125642045C>G	uc010mwc.1	-	8	1442	c.1201G>C	c.(1201-1203)GAG>CAG	p.E401Q	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.E401Q|RC3H2_uc004bne.3_Missense_Mutation_p.E401Q|RC3H2_uc011lzf.1_Missense_Mutation_p.E138Q|RC3H2_uc011lzg.1_Missense_Mutation_p.E401Q	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	401						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						TGAGGGGTCTCATGGCCTTTT	0.393													20	62					0	0	0	0	G	125642045	G	G	125642045	3	3	36	1	0	0	0	0	1	0	0	0	13232	835	29	2	2508	2	RC3H2	9	125642045	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2468352	125642045	15571386	532	7332											
MAPKAP1	79109	broad.mit.edu	37	chr9	128268677	128268677	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acattgggctcgctctgcttCtccaggcggtactgagggcc	5	10	13	13	2	2	1	0	1	2	0	4	1	2	1	2	4	2	4	2	4	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:128268677C>T	uc004bpv.2	-	8	1311	c.978G>A	c.(976-978)GAG>GAA	p.E326E	MAPKAP1_uc011lzt.1_Silent_p.E129E|MAPKAP1_uc010mwz.2_Intron|MAPKAP1_uc011lzu.1_Silent_p.E129E|MAPKAP1_uc011lzv.1_Intron|MAPKAP1_uc004bpw.2_Silent_p.E134E|MAPKAP1_uc004bpx.2_Silent_p.E134E|MAPKAP1_uc004bpy.2_Intron|MAPKAP1_uc004bpz.2_Silent_p.E326E|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc010mxb.1_Silent_p.E129E	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	326					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						CGCTCTGCTTCTCCAGGCGGT	0.552													35	107					0	0	0	0	T	128268677	T	T	128268677	2	4	36	1	0	0	0	0	0	0	0	1	9341	912	32	2		2	MAPKAP1	9	128268677	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2626632	128268677	12944754	533	7333											
ODF2	4957	broad.mit.edu	37	chr9	131231605	131231605	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaagattgatagtctaatGaatgcggttggttgtctgaa	13	13	12	3	1	2	5	0	3	2	2	2	5	2	5	0	2	1	2	0	2	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:131231605G>A	uc011mbd.1	+	5	704	c.393G>A	c.(391-393)ATG>ATA	p.M131I	ODF2_uc011maz.1_Missense_Mutation_p.M131I|ODF2_uc011mba.1_Intron|ODF2_uc010myb.2_Missense_Mutation_p.M107I|ODF2_uc011mbb.1_Missense_Mutation_p.M65I|ODF2_uc011mbc.1_Intron|ODF2_uc004bva.2_Missense_Mutation_p.M84I|ODF2_uc004bvb.2_Missense_Mutation_p.M107I|ODF2_uc011mbe.1_Missense_Mutation_p.M126I|ODF2_uc004bvc.2_Missense_Mutation_p.M107I|ODF2_uc010myc.2_Intron|ODF2_uc011mbf.1_Missense_Mutation_p.M112I|ODF2_uc004bvd.3_Missense_Mutation_p.M131I|ODF2_uc004bve.2_Missense_Mutation_p.M112I	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	131					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						ATAGTCTAATGAATGCGGTTG	0.488													51	205					0	0	0	0	A	131231605	A	A	131231605	3	1	36	1	0	0	0	0	1	0	0	0	10881	1290	45	2	462	2	ODF2	9	131231605	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2962928	131231605	9981826	534	7334											
MED27	9442	broad.mit.edu	37	chr9	134952852	134952852	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttgaccacttatatgcttGaaggagttgactatagagag	12	13	11	5	0	0	4	0	3	0	1	0	6	0	5	1	1	1	3	1	1	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:134952852G>C	uc004cbe.1	-	2	347	c.325C>G	c.(325-327)CAA>GAA	p.Q109E	MED27_uc004cbf.1_Missense_Mutation_p.Q109E|MED27_uc011mco.1_Missense_Mutation_p.Q109E|MED27_uc004cbg.3_Missense_Mutation_p.Q109E	NM_004269	NP_004260	Q6P2C8	MED27_HUMAN	mediator complex subunit 27	109					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleolus|transcription factor complex	protein binding|transcription coactivator activity			skin(1)	1		Myeloproliferative disorder(178;0.206)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000193)		TTATATGCTTGAAGGAGTTGA	0.413													10	286					0	0	0	0	C	134952852	C	C	134952852	3	2	36	1	0	0	0	0	1	0	0	0	9498	1299	45	2	638	2	MED27	9	134952852	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3721247	134952852	6260579	535	7335											
TTF1	7270	broad.mit.edu	37	chr9	135277284	135277284	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcccacagcaggccgggattCctgcatatcagccccaacct	9	6	9	17	1	1	0	1	0	0	0	2	1	2	1	6	2	4	2	6	2	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:135277284C>G	uc004cbl.2	-	2	977	c.925G>C	c.(925-927)GAA>CAA	p.E309Q	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	309					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		GGCCGGGATTCCTGCATATCA	0.448													5	319					0	0	0	0	G	135277284	G	G	135277284	3	3	36	1	0	0	0	0	1	0	0	0	16786	864	30	2	1832	2	TTF1	9	135277284	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	324432	135277284	5936147	536	7336											
CAMSAP1	157922	broad.mit.edu	37	chr9	138719360	138719360	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctgcagcagggctgcctagGaaactgcgtttggtcgcgtt	6	10	14	11	3	0	0	0	0	0	0	1	1	0	1	2	3	5	5	2	3	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:138719360G>A	uc004cgr.3	-	8	1116	c.1116C>T	c.(1114-1116)TTC>TTT	p.F372F	CAMSAP1_uc004cgq.3_Silent_p.F262F|CAMSAP1_uc010nbg.2_Silent_p.F94F	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	372						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GGCTGCCTAGGAAACTGCGTT	0.597													11	37					0	0	0	0	A	138719360	A	A	138719360	2	1	36	1	0	0	0	0	0	0	0	1	2623	1165	41	2		2	CAMSAP1	9	138719360	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3442076	138719360	2494071	537	7337											
NOTCH1	4851	broad.mit.edu	37	chr9	139417620	139417620	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggttggaggcgcacgggtCagcctgctggcacgatttcc	5	8	17	11	3	1	0	1	0	0	0	2	2	2	1	2	6	2	4	2	6	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:139417620C>G	uc004chz.2	-	4	424	c.424G>C	c.(424-426)GAC>CAC	p.D142H		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	142	Extracellular (Potential).|EGF-like 4.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCGCACGGGTCAGCCTGCTGG	0.682			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			6	12					0	0	0	0	G	139417620	G	G	139417620	3	3	36	1	0	0	0	0	1	0	0	0	10601	826	29	2	7367	2	NOTCH1	9	139417620	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	698260	139417620	1795811	538	7338											
C9orf86	55684	broad.mit.edu	37	chr9	139720263	139720263	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcgtgaaggttgaagtctggGatgtagtagacaaaggtgag	12	10	16	3	1	1	4	0	3	1	1	2	5	1	5	0	3	0	3	0	3	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:139720263G>A	uc004cji.1	+	3	566	c.298G>A	c.(298-300)GAT>AAT	p.D100N	C9orf86_uc004cjm.2_Missense_Mutation_p.D100N|C9orf86_uc004cjh.2_Missense_Mutation_p.D100N|C9orf86_uc004cjj.1_Missense_Mutation_p.D100N|C9orf86_uc004cjk.1_RNA|C9orf86_uc010nbr.1_Missense_Mutation_p.D100N|C9orf86_uc004cjl.1_RNA|C9orf86_uc010nbs.1_5'UTR	NM_024718	NP_078994	Q3YEC7	PARF_HUMAN	Rab-like GTP-binding protein 1 isoform 1	100	Small GTPase-like.|GTP (Potential).				small GTPase mediated signal transduction	cytoplasm|nucleus	GTP binding|protein binding				0	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.61e-05)|Epithelial(140;0.000183)		TGAAGTCTGGGATGTAGTAGA	0.532													6	338					0	0	0	0	A	139720263	A	A	139720263	3	1	36	1	0	0	0	0	1	0	0	0	2514	1174	41	2	308	2	C9orf86	9	139720263	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	302643	139720263	1493168	539	7339											
ABCA2	20	broad.mit.edu	37	chr9	139909403	139909403	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcccccttcttggcggcctCgctgggcaggatgtaggaga	6	8	15	12	2	1	1	0	0	1	1	2	3	1	2	3	5	1	3	3	5	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr9:139909403C>T	uc011mem.1	-	24	3989	c.3841G>A	c.(3841-3843)GAG>AAG	p.E1281K	ABCA2_uc011mel.1_Missense_Mutation_p.E1282K|ABCA2_uc004ckl.1_Missense_Mutation_p.E1212K|ABCA2_uc004ckm.1_Missense_Mutation_p.E1312K|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1281					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TTGGCGGCCTCGCTGGGCAGG	0.662													11	23					0	0	0	0	T	139909403	T	T	139909403	3	4	36	1	0	0	0	0	1	0	0	0	32	893	31	1	3566	1	ABCA2	9	139909403	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	189140	139909403	1304028	540	7340											
SFMBT2	57713	broad.mit.edu	37	chr10	7262467	7262467	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggttcacagcttcaagtttCatgttctttgtgaaacctcg	8	15	9	9	1	4	1	3	1	1	0	5	1	4	1	1	1	2	4	1	1	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:7262467C>T	uc009xio.1	-	11	1327	c.1236G>A	c.(1234-1236)ATG>ATA	p.M412I	SFMBT2_uc001ijn.1_Missense_Mutation_p.M412I|SFMBT2_uc010qay.1_Intron	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	412	MBT 4.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						CTTCAAGTTTCATGTTCTTTG	0.517													62	116					0	0	0	0	T	7262467	T	T	7262467	3	4	36	1	0	0	0	0	1	0	0	0	14223	826	29	2	1492	2	SFMBT2	10	7262467	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08		7262467	128272280	541	7341											
DHTKD1	55526	broad.mit.edu	37	chr10	12162209	12162209	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagtcaggaggaacctcaGaacatgggtccgtggtcgtt	9	9	15	8	2	2	1	2	0	0	1	4	4	3	4	2	5	2	1	2	5	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:12162209G>A	uc001ild.3	+	16	2700	c.2601G>A	c.(2599-2601)CAG>CAA	p.Q867Q		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	867					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			AGGAACCTCAGAACATGGGTC	0.378													79	115					0	0	0	0	A	12162209	A	A	12162209	2	1	36	1	0	0	0	0	0	0	0	1	4522	933	33	2		2	DHTKD1	10	12162209	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4899742	12162209	123372538	542	7342											
OLAH	55301	broad.mit.edu	37	chr10	15115168	15115168	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttctggatcctgcgaacgaGaaattaatcaagaactacat	15	10	7	9	2	2	2	1	0	1	2	3	5	3	3	1	1	4	0	1	1	6	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:15115168G>A	uc001inu.2	+	8	992	c.738G>A	c.(736-738)GAG>GAA	p.E246E	ACBD7_uc010qby.1_Intron|OLAH_uc001int.2_Silent_p.E299E	NM_001039702	NP_001034791	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase isoform 2	246					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity				0						CTGCGAACGAGAAATTAATCA	0.328													33	61					0	0	0	0	A	15115168	A	A	15115168	2	1	36	1	0	0	0	0	0	0	0	1	10905	933	33	2		2	OLAH	10	15115168	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2952959	15115168	120419579	543	7343											
STAM	8027	broad.mit.edu	37	chr10	17747604	17747604	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaaaacattcagaactctCagaacttaatgtgaaagtga	18	9	7	7	0	2	5	2	2	1	3	3	5	2	5	0	0	3	0	0	0	6	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:17747604C>G	uc001ipj.1	+	12	1289	c.1073C>G	c.(1072-1074)TCA>TGA	p.S358*	STAM_uc009xjw.1_Intron	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	358					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2						TCAGAACTCTCAGAACTTAAT	0.323													4	89					0	0	0	0	G	17747604	G	G	17747604	4	3	36	1	0	0	0	0	0	1	0	0	15314	838	29	2	1119	2	STAM	10	17747604	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2632436	17747604	117787143	544	7344											
KIAA1217	56243	broad.mit.edu	37	chr10	24835129	24835129	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctccttctcctgcctcctCcgtctcactgaatcaaggtg	5	12	6	18	1	3	1	2	1	2	0	8	1	6	1	6	1	1	0	6	1	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:24835129C>T	uc001iru.3	+	21	6111	c.5708C>T	c.(5707-5709)TCC>TTC	p.S1903F	KIAA1217_uc001irs.2_Missense_Mutation_p.S1224F|KIAA1217_uc001irt.3_Missense_Mutation_p.S1269F|KIAA1217_uc010qcy.1_Missense_Mutation_p.S1334F|KIAA1217_uc010qcz.1_Missense_Mutation_p.S1309F|KIAA1217_uc001irw.2_3'UTR|KIAA1217_uc001irz.2_3'UTR|KIAA1217_uc001irx.2_3'UTR|KIAA1217_uc001iry.2_3'UTR	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1903	Ser-rich.				embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						cctgcctcctccgtctcACTG	0.383													30	49					0	0	0	0	T	24835129	T	T	24835129	3	4	36	1	0	0	0	0	1	0	0	0	8255	855	30	2	5790	2	KIAA1217	10	24835129	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	7087525	24835129	110699618	545	7345											
PARD3	56288	broad.mit.edu	37	chr10	34649066	34649066	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatctgcgtggttctcttttGaccggttacctttgacactg	6	16	9	10	2	2	2	0	2	2	0	3	2	2	2	2	2	2	2	2	2	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:34649066G>C	uc010qej.1	-	13	1829	c.1829C>G	c.(1828-1830)TCA>TGA	p.S610*	PARD3_uc010qek.1_Nonsense_Mutation_p.S610*|PARD3_uc010qel.1_Nonsense_Mutation_p.S610*|PARD3_uc010qem.1_Nonsense_Mutation_p.S597*|PARD3_uc010qen.1_Nonsense_Mutation_p.S597*|PARD3_uc010qeo.1_Nonsense_Mutation_p.S597*|PARD3_uc010qep.1_Nonsense_Mutation_p.S553*|PARD3_uc010qeq.1_Nonsense_Mutation_p.S553*|PARD3_uc001ixo.1_Nonsense_Mutation_p.S327*|PARD3_uc001ixp.1_Nonsense_Mutation_p.S475*|PARD3_uc001ixq.1_Nonsense_Mutation_p.S597*|PARD3_uc001ixr.1_Nonsense_Mutation_p.S610*|PARD3_uc001ixt.1_Nonsense_Mutation_p.S431*|PARD3_uc001ixu.1_Nonsense_Mutation_p.S553*|PARD3_uc001ixs.1_Nonsense_Mutation_p.S263*	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	610	PDZ 3.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				GTTCTCTTTTGACCGGTTACC	0.433													37	107					0	0	0	0	C	34649066	C	C	34649066	4	2	36	1	0	0	0	0	0	1	0	0	11497	1294	45	2	2328	2	PARD3	10	34649066	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	9813937	34649066	100885681	546	7346											
CSGALNACT2	55454	broad.mit.edu	37	chr10	43650991	43650991	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcccaaattgacaaagctGaagttagcataggggccaaa	16	8	9	8	0	0	2	0	2	0	0	1	2	1	2	2	2	2	3	2	2	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:43650991G>C	uc001jan.2	+	2	729	c.394G>C	c.(394-396)GAA>CAA	p.E132Q	CSGALNACT2_uc001jam.1_Missense_Mutation_p.E132Q	NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	132	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						TGACAAAGCTGAAGTTAGCAT	0.413													44	63					0	0	0	0	C	43650991	C	C	43650991	3	2	36	1	0	0	0	0	1	0	0	0	3956	1291	45	2	396	2	CSGALNACT2	10	43650991	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	9001925	43650991	91883756	547	7347											
ZNF22	7570	broad.mit.edu	37	chr10	45498928	45498928	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaagtggggcatgactattCgatttgactcaagcttcagt	11	12	11	7	1	2	3	2	2	0	1	3	4	2	3	0	2	1	2	0	2	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:45498928C>T	uc001jbw.2	+	2	355	c.112C>T	c.(112-114)CGA>TGA	p.R38*	C10orf25_uc010qff.1_5'Flank|C10orf25_uc001jbv.1_5'Flank|uc001jbx.1_RNA	NM_006963	NP_008894	P17026	ZNF22_HUMAN	zinc finger protein 22 (KOX 15)	38					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			breast(1)|kidney(1)	2		Prostate(175;0.0352)|all_neural(218;0.202)				CATGACTATTCGATTTGACTC	0.453													54	65					0	0	0	0	T	45498928	T	T	45498928	4	4	36	1	0	0	0	0	0	1	0	0	17841	876	31	1	114	1	ZNF22	10	45498928	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1847937	45498928	90035819	548	7348											
JMJD1C	221037	broad.mit.edu	37	chr10	64968002	64968002	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaggtggaggctttgaaaGagatgttataaatgaagtca	16	10	12	3	0	1	3	1	2	0	1	1	5	1	4	0	3	0	2	0	3	6	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:64968002G>C	uc001jmn.2	-	10	3727	c.3427C>G	c.(3427-3429)CTT>GTT	p.L1143V	JMJD1C_uc001jml.2_Missense_Mutation_p.L924V|JMJD1C_uc001jmm.2_Missense_Mutation_p.L855V|JMJD1C_uc010qiq.1_Missense_Mutation_p.L961V|JMJD1C_uc009xpi.2_Missense_Mutation_p.L961V|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.L180V	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1143					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GGCTTTGAAAGAGATGTTATA	0.408													8	319					0	0	0	0	C	64968002	C	C	64968002	3	2	36	1	0	0	0	0	1	0	0	0	7989	942	33	2	4263	2	JMJD1C	10	64968002	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	19469074	64968002	70566745	549	7349											
STOX1	219736	broad.mit.edu	37	chr10	70646010	70646010	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaacctaacctctctgctGaaagttgtggcctaaattca	13	11	7	10	0	2	2	1	1	1	1	3	2	2	2	3	1	3	2	3	1	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:70646010G>A	uc001jos.2	+	3	2545	c.2458G>A	c.(2458-2460)GAA>AAA	p.E820K	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Missense_Mutation_p.E710K	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	820						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						CCTCTCTGCTGAAAGTTGTGG	0.483													56	65					0	0	0	0	A	70646010	A	A	70646010	3	1	36	1	0	0	0	0	1	0	0	0	15385	1291	45	2	2468	2	STOX1	10	70646010	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5678008	70646010	64888737	550	7350											
NRG3	10718	broad.mit.edu	37	chr10	83635424	83635424	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggactccaaggggatgggcCaggaccccttcttcctctcc	6	9	11	15	0	2	0	0	0	2	0	5	3	4	3	6	5	0	0	6	5	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:83635424C>A	uc001kco.2	+	1	355	c.328C>A	c.(328-330)CAG>AAG	p.Q110K	NRG3_uc010qlz.1_Missense_Mutation_p.Q110K|NRG3_uc001kcp.2_5'Flank|NRG3_uc001kcq.2_5'Flank	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	110	Ser/Thr-rich.|Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GGGGATGGGCCAGGACCCCTT	0.473													24	40					1.85244e-09	1.92641e-09	1	0	A	83635424	A	A	83635424	3	1	36	1	0	0	0	0	1	0	0	0	10703	595	21	4	330	4	NRG3	10	83635424	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	12989414	83635424	51899323	551	7351											
PTEN	5728	broad.mit.edu	37	chr10	89624268	89624268	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcgttagcagaaacaaaagGagatatcaagaggatggatt	18	8	11	4	1	1	3	1	0	0	3	2	6	1	5	0	3	2	2	0	3	6	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:89624268G>T	uc001kfb.2	+	2	1073	c.42G>T	c.(40-42)AGG>AGT	p.R14S	KILLIN_uc009xti.2_5'Flank	NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	14	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(13)|p.0?(12)|p.R14G(2)|p.R14fs*29(1)|p.R14fs*26(1)|p.I8_R14>LRLICIF(1)|p.R14fs*10(1)|p.N12fs*6(1)|p.R14_D22del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GAAACAAAAGGAGATATCAAG	0.478		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			61	56					6.2918e-36	6.81519e-36	1	0	T	89624268	T	T	89624268	3	4	36	1	0	0	0	0	1	0	0	0	12800	1165	41	2	44	2	PTEN	10	89624268	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5988844	89624268	45910479	552	7352											
PDE6C	5146	broad.mit.edu	37	chr10	95372755	95372755	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagaggctggcccacctgctCcaggctgaccgctgcagcat	7	6	12	16	1	0	2	0	1	0	1	1	2	1	2	4	3	3	6	4	3	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:95372755C>G	uc001kiu.3	+	1	411	c.273C>G	c.(271-273)CTC>CTG	p.L91L		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	91	GAF 1.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				CCCACCTGCTCCAGGCTGACC	0.657													21	32					0	0	0	0	G	95372755	G	G	95372755	2	3	36	1	0	0	0	0	0	0	0	1	11701	842	30	2		2	PDE6C	10	95372755	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5748487	95372755	40161992	553	7353											
CYP2C9	1559	broad.mit.edu	37	chr10	96701723	96701723	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccctgattgatcttggagagGagttttctggaagaggcatt	9	13	13	6	0	2	4	0	2	2	2	2	7	2	6	1	4	0	2	1	4	1	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:96701723G>A	uc001kka.3	+	2	302	c.277G>A	c.(277-279)GAG>AAG	p.E93K	CYP2C9_uc009xut.2_Missense_Mutation_p.E93K|CYP2C9_uc001kjz.2_Missense_Mutation_p.E93K	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	93					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TCTTGGAGAGGAGTTTTCTGG	0.493													7	256					0	0	0	0	A	96701723	A	A	96701723	3	1	36	1	0	0	0	0	1	0	0	0	4185	1175	41	2	283	2	CYP2C9	10	96701723	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1328968	96701723	38833024	554	7354											
MGEA5	10724	broad.mit.edu	37	chr10	103558920	103558920	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatcagtgtccattggtttCaattcctctgccattttcgc	6	18	6	11	1	3	0	2	0	1	0	6	0	5	0	3	1	1	1	3	1	2	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:103558920C>G	uc001ktv.2	-	9	1931	c.1488G>C	c.(1486-1488)TTG>TTC	p.L496F	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Missense_Mutation_p.L443F|MGEA5_uc009xws.2_Missense_Mutation_p.L443F|MGEA5_uc001ktw.2_Missense_Mutation_p.L496F|MGEA5_uc009xwt.2_Missense_Mutation_p.L259F	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	496					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		CCATTGGTTTCAATTCCTCTG	0.413													5	477					0	0	0	0	G	103558920	G	G	103558920	3	3	36	1	0	0	0	0	1	0	0	0	9608	825	29	2	1294	2	MGEA5	10	103558920	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6857197	103558920	31975827	555	7355											
CALHM2	51063	broad.mit.edu	37	chr10	105209672	105209672	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagaaaagtgacaggaagcgGaagttctctgcgatcagggc	14	6	14	7	2	2	2	1	1	1	1	3	5	2	4	0	3	2	1	0	3	5	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:105209672G>A	uc001kwz.2	-	2	413	c.27C>T	c.(25-27)TTC>TTT	p.F9F	CALHM2_uc001kxa.2_Silent_p.F9F|CALHM2_uc001kxc.2_Silent_p.F9F|CALHM2_uc001kxb.2_Silent_p.F9F|CALHM2_uc001kxd.1_Silent_p.F9F	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	9						integral to membrane				skin(1)	1						ACAGGAAGCGGAAGTTCTCTG	0.577													68	79					0	0	0	0	A	105209672	A	A	105209672	2	1	36	1	0	0	0	0	0	0	0	1	2595	1165	41	2		2	CALHM2	10	105209672	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1650752	105209672	30325075	556	7356											
PNLIPRP2	5408	broad.mit.edu	37	chr10	118386480	118386480	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acattcgggttgttggggcgGagacagctttcttaatacaa	10	12	12	7	2	1	1	0	0	1	1	2	2	1	1	0	4	2	3	0	4	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:118386480G>C	uc001lcq.2	+	7	462	c.439G>C	c.(439-441)GAG>CAG	p.E147Q	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	146					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		TGTTGGGGCGGAGACAGCTTT	0.577													15	16					0	0	0	0	C	118386480	C	C	118386480	3	2	36	1	0	0	0	0	1	0	0	0	12206	1175	41	2	456	2	PNLIPRP2	10	118386480	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	13176808	118386480	17148267	557	7357											
BAG3	9531	broad.mit.edu	37	chr10	121436717	121436717	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atccccacacagaaacccagCagccagaagccacagcagca	16	1	7	17	0	0	2	0	0	0	2	1	2	1	2	5	0	6	3	5	0	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:121436717C>T	uc001lem.2	+	4	1957	c.1651C>T	c.(1651-1653)CAG>TAG	p.Q551*	BAG3_uc001lel.2_Nonsense_Mutation_p.Q550*	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	551					anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		AGAAACCCAGCAGCCAGAAGC	0.552													31	52					0	0	0	0	T	121436717	T	T	121436717	4	4	36	1	0	0	0	0	0	1	0	0	1290	711	25	4	1665	4	BAG3	10	121436717	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3050237	121436717	14098030	558	7358											
ACADSB	36	broad.mit.edu	37	chr10	124800176	124800176	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccacctatttgcctcagctCactacagaaaaagtgagttg	12	10	8	11	0	2	2	2	1	0	1	2	2	2	2	3	0	3	2	3	0	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:124800176C>G	uc001lhb.2	+	4	615	c.498C>G	c.(496-498)CTC>CTG	p.L166L	ACADSB_uc010qub.1_Silent_p.L64L	NM_001609	NP_001600	P45954	ACDSB_HUMAN	acyl-Coenzyme A dehydrogenase, short/branched	166					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	TGCCTCAGCTCACTACAGAAA	0.358													58	51					0	0	0	0	G	124800176	G	G	124800176	2	3	36	1	0	0	0	0	0	0	0	1	115	813	29	2		2	ACADSB	10	124800176	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3363459	124800176	10734571	559	7359											
FAM53B	9679	broad.mit.edu	37	chr10	126311954	126311954	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgcagctgtctgactcctCacaggacaggtcctcctggc	6	8	12	15	1	2	1	1	1	1	0	5	2	5	2	3	4	1	2	3	4	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:126311954C>T	uc001lhv.1	-	5	1649	c.1126G>A	c.(1126-1128)GAG>AAG	p.E376K	FAM53B_uc001lhu.1_Intron	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	376										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		TCTGACTCCTCACAGGACAGG	0.716													5	29					0	0	0	0	T	126311954	T	T	126311954	3	4	36	1	0	0	0	0	1	0	0	0	5612	835	29	2	146	2	FAM53B	10	126311954	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1511778	126311954	9222793	560	7360											
CTBP2	1488	broad.mit.edu	37	chr10	126681775	126681775	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcacggaggggctcacctgtGatggctcggcggatctcggt	5	8	17	11	4	2	1	1	1	1	0	4	3	2	3	1	7	0	3	1	7	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:126681775G>A	uc009yak.2	-	9	1322	c.1035C>T	c.(1033-1035)ATC>ATT	p.I345I	CTBP2_uc009yal.2_Silent_p.I345I|CTBP2_uc001lif.3_Silent_p.I345I|CTBP2_uc001lih.3_Silent_p.I345I|CTBP2_uc001lid.3_Silent_p.I413I|CTBP2_uc001lie.3_Silent_p.I885I	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	345					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GCTCACCTGTGATGGCTCGGC	0.642													9	14					0	0	0	0	A	126681775	A	A	126681775	2	1	36	1	0	0	0	0	0	0	0	1	4015	1280	45	2		2	CTBP2	10	126681775	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	369821	126681775	8852972	561	7361											
ADAM12	8038	broad.mit.edu	37	chr10	127806646	127806646	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagggtggtggaaacacattCtttgcagcgaggtttggtgt	8	12	16	5	1	1	0	0	0	1	0	1	3	1	1	0	5	3	2	0	5	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:127806646C>G	uc001ljk.2	-	6	986	c.573G>C	c.(571-573)AAG>AAC	p.K191N	ADAM12_uc010qul.1_Missense_Mutation_p.K188N|ADAM12_uc001ljm.2_Missense_Mutation_p.K191N|ADAM12_uc001ljn.2_Missense_Mutation_p.K188N|ADAM12_uc001ljl.3_Missense_Mutation_p.K188N	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	191					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GAAACACATTCTTTGCAGCGA	0.493													33	311					0	0	0	0	G	127806646	G	G	127806646	3	3	36	1	0	0	0	0	1	0	0	0	236	912	32	2	2336	2	ADAM12	10	127806646	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1124871	127806646	7728101	562	7362											
JAKMIP3	282973	broad.mit.edu	37	chr10	133930805	133930805	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcggctgcaggcactgctCagtgccctgcgtgatggcgg	5	7	16	13	3	1	1	1	1	0	0	1	1	1	1	1	4	5	4	1	4	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:133930805C>G	uc001lkx.3	+	2	360	c.360C>G	c.(358-360)CTC>CTG	p.L120L		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGGCACTGCTCAGTGCCCTGC	0.612													24	29					0	0	0	0	G	133930805	G	G	133930805	2	3	36	1	0	0	0	0	0	0	0	1	7981	813	29	2		2	JAKMIP3	10	133930805	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6124159	133930805	1603942	563	7363											
TUBGCP2	10844	broad.mit.edu	37	chr10	135106655	135106655	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagctgtgacaccagaatCaggtgctccttcaccagggt	9	9	10	13	0	2	2	2	1	0	1	4	2	4	2	4	2	2	2	4	2	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:135106655C>T	uc001lmg.1	-	7	1269	c.912G>A	c.(910-912)CTG>CTA	p.L304L	TUBGCP2_uc001lmf.1_5'Flank|TUBGCP2_uc010qvc.1_Silent_p.L332L|TUBGCP2_uc009ybk.1_Silent_p.L304L|TUBGCP2_uc010qvd.1_Silent_p.L174L|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	304					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		ACACCAGAATCAGGTGCTCCT	0.592													53	43					0	0	0	0	T	135106655	T	T	135106655	2	4	36	1	0	0	0	0	0	0	0	1	16834	813	29	2		2	TUBGCP2	10	135106655	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1175850	135106655	428092	564	7364											
MTG1	92170	broad.mit.edu	37	chr10	135212703	135212703	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atggtcactgaactgattggGagaagccaccgctaccaccg	11	7	11	12	2	1	3	1	2	0	1	1	4	1	3	4	2	3	1	4	2	3	2	rs142057422		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:135212703G>C	uc001lnd.2	+	5	497	c.393G>C	c.(391-393)GGG>GGC	p.G131G	MTG1_uc010qve.1_Silent_p.G47G	NM_138384	NP_612393	Q9BT17	MTG1_HUMAN	GTP_binding protein precursor	131						mitochondrion	GTP binding|protein binding			skin(1)	1		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|all cancers(32;1.69e-06)|Epithelial(32;1.94e-06)		AACTGATTGGGAGAAGCCACC	0.632													29	29					0	0	0	0	C	135212703	C	C	135212703	2	2	36	1	0	0	0	0	0	0	0	1	9979	1161	41	2		2	MTG1	10	135212703	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	106048	135212703	322044	565	7365											
CYP2E1	1571	broad.mit.edu	37	chr10	135345198	135345198	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aatgagagccggatccagagGgaggcccacttcctgctgga	10	6	14	11	1	0	2	0	1	0	2	2	6	2	5	4	4	2	1	4	4	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr10:135345198G>C	uc001lnj.1	+	3	480	c.447G>C	c.(445-447)AGG>AGC	p.R149S	CYP2E1_uc001lnk.1_Missense_Mutation_p.R12S|CYP2E1_uc009ybl.1_Intron|CYP2E1_uc009ybm.1_5'UTR|CYP2E1_uc001lnl.1_5'UTR	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	149					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	GGATCCAGAGGGAGGCCCACT	0.597									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				59	72					0	0	0	0	C	135345198	C	C	135345198	3	2	36	1	0	0	0	0	1	0	0	0	4187	1223	43	4	457	4	CYP2E1	10	135345198	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	132495	135345198	189549	566	7366											
SIGIRR	59307	broad.mit.edu	37	chr11	407115	407115	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaggcgtccgaaagcaccacGatgaggcgtcggcagcggct	10	4	15	12	6	0	1	0	1	0	0	2	3	1	1	2	4	2	3	2	4	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:407115G>A	uc001lpd.2	-	7	1005	c.675C>T	c.(673-675)ATC>ATT	p.I225I	SIGIRR_uc001lpf.2_Silent_p.I225I|SIGIRR_uc001lpe.1_Silent_p.I225I|SIGIRR_uc001lpg.2_Silent_p.I225I	NM_001135054	NP_001128526	Q6IA17	SIGIR_HUMAN	single Ig IL-1R-related molecule	225	Cytoplasmic (Potential).|TIR.				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity				0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAAGCACCACGATGAGGCGTC	0.542													5	14					0	0	0	0	A	407115	A	A	407115	2	1	36	1	0	0	0	0	0	0	0	1	14369	1048	37	1		1	SIGIRR	11	407115	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08		407115	134599401	567	7367											
RNH1	6050	broad.mit.edu	37	chr11	500607	500607	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagggttgactcgaagtgcaGagctgatgtccttgcaccgt	8	10	13	10	2	0	3	0	2	0	1	2	4	1	3	2	1	3	4	2	1	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:500607G>C	uc001lpk.1	-	2	1557	c.149C>G	c.(148-150)TCT>TGT	p.S50C	RNH1_uc001lpl.1_Missense_Mutation_p.S50C|RNH1_uc001lpm.1_Missense_Mutation_p.S50C|RNH1_uc001lpn.1_Missense_Mutation_p.S50C|RNH1_uc001lpo.1_Missense_Mutation_p.S50C|RNH1_uc009ybw.1_RNA|RNH1_uc001lpp.1_Missense_Mutation_p.S50C|RNH1_uc001lpt.1_5'UTR|RNH1_uc001lpq.1_Missense_Mutation_p.S50C|RNH1_uc001lpr.1_Missense_Mutation_p.S50C|RNH1_uc001lps.1_Missense_Mutation_p.S50C|RNH1_uc009ybx.1_Missense_Mutation_p.S50C	NM_203389	NP_976323	P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor	50	LRR 2.				mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity				0		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCGAAGTGCAGAGCTGATGTC	0.642													20	60					0	0	0	0	C	500607	C	C	500607	3	2	36	1	0	0	0	0	1	0	0	0	13569	942	33	2	1268	2	RNH1	11	500607	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	93492	500607	134505909	568	7368											
C11orf35	256329	broad.mit.edu	37	chr11	558713	558713	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggcctggatctccagttctCgctgtctccacagcagccgc	6	9	10	16	2	3	0	0	0	3	0	6	1	3	1	4	2	2	3	4	2	0	1	rs148047813	byFrequency	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:558713C>T	uc001lpx.2	-	3	275	c.212G>A	c.(211-213)CGA>CAA	p.R71Q	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank|RASSF7_uc001lqb.2_5'Flank|RASSF7_uc001lqc.2_5'Flank|RASSF7_uc001lqd.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	71										pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTCCAGTTCTCGCTGTCTCCA	0.672													10	8					0	0	0	0	T	558713	T	T	558713	3	4	36	1	0	0	0	0	1	0	0	0	1644	884	31	1	1740	1	C11orf35	11	558713	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	58106	558713	134447803	569	7369											
DEAF1	10522	broad.mit.edu	37	chr11	691546	691546	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgttcgccacagacgtggtGaagacattgtctgcagcagc	9	8	13	11	3	1	3	0	1	1	2	2	3	1	3	1	1	3	3	1	1	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:691546G>A	uc001lqq.1	-	2	1035	c.342C>T	c.(340-342)TTC>TTT	p.F114F		NM_021008	NP_066288	O75398	DEAF1_HUMAN	deformed epidermal autoregulatory factor 1	114	Ala-rich.				embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding				0		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		CAGACGTGGTGAAGACATTGT	0.592													15	42					0	0	0	0	A	691546	A	A	691546	2	1	36	1	0	0	0	0	0	0	0	1	4397	1281	45	2		2	DEAF1	11	691546	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	132833	691546	134314970	570	7370											
CTSD	1509	broad.mit.edu	37	chr11	1774754	1774754	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagaggcgggcagcctcggcGaagcccaccctgttgttgtc	6	8	14	13	3	0	1	0	0	0	1	2	2	0	1	3	3	2	3	3	3	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:1774754G>A	uc001luc.1	-	9	1351	c.1218C>T	c.(1216-1218)TTC>TTT	p.F406F	uc001lub.1_5'Flank|CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	406					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAGCCTCGGCGAAGCCCACCC	0.667													19	64					0	0	0	0	A	1774754	A	A	1774754	2	1	36	1	0	0	0	0	0	0	0	1	4049	1049	37	1		1	CTSD	11	1774754	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1083208	1774754	133231762	571	7371											
RRM1	6240	broad.mit.edu	37	chr11	4132854	4132854	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagagcggtcttatttgttGaagatcaatggaaaaggtga	13	12	12	4	1	2	4	1	2	1	2	2	5	2	5	0	3	1	1	0	3	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:4132854G>T	uc001lyw.3	+	6	790	c.471G>T	c.(469-471)TTG>TTT	p.L157F	RRM1_uc009yeh.1_Missense_Mutation_p.L60F|RRM1_uc009yei.2_Missense_Mutation_p.L117F|RRM1_uc010qyc.1_Missense_Mutation_p.L60F	NM_001033	NP_001024	P23921	RIR1_HUMAN	ribonucleoside-diphosphate reductase M1 chain	157					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	CTTATTTGTTGAAGATCAATG	0.328													29	77					4.3181e-19	4.58798e-19	1	0	T	4132854	T	T	4132854	3	4	36	1	0	0	0	0	1	0	0	0	13746	1281	45	2	493	2	RRM1	11	4132854	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2358100	4132854	130873662	572	7372											
OR52A4	390053	broad.mit.edu	37	chr11	5142422	5142422	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcctcagaggataacagatCgctacacagcggtccagagc	12	5	11	13	3	1	3	1	0	0	3	3	4	2	4	2	2	4	1	2	2	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:5142422C>T	uc001lzz.1	-	1	387	c.387G>A	c.(385-387)GCG>GCA	p.A129A	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		GATAACAGATCGCTACACAGC	0.463													21	44					0	0	0	0	T	5142422	T	T	5142422	2	4	36	1	0	0	0	0	0	0	0	1	11163	871	31	1		1	OR52A4	11	5142422	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1009568	5142422	129864094	573	7373											
TRIM5	85363	broad.mit.edu	37	chr11	5701231	5701231	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttctcaggctggtaactgatCcggcacacagggcagctact	9	9	11	12	1	1	1	1	1	1	0	3	1	2	1	1	4	3	5	1	4	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:5701231C>G	uc001mbm.1	-	2	434	c.177G>C	c.(175-177)CGG>CGC	p.R59R	TRIM5_uc001mbq.1_Silent_p.R59R|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Silent_p.R59R|TRIM5_uc001mbo.2_Silent_p.R59R|TRIM5_uc001mbp.2_Silent_p.R59R	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	59	RING-type.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		GGTAACTGATCCGGCACACAG	0.547													6	234					0	0	0	0	G	5701231	G	G	5701231	2	3	36	1	0	0	0	0	0	0	0	1	16592	842	30	2		2	TRIM5	11	5701231	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	558809	5701231	129305285	574	7374											
DNHD1	144132	broad.mit.edu	37	chr11	6519765	6519765	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccttgatttgctgccctTcctggagcagctgtactgct	5	13	9	14	0	0	1	0	1	0	0	1	2	1	2	4	1	6	5	4	1	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:6519765T>G	uc001mdw.3	+	3	884	c.320T>G	c.(319-321)TTC>TGC	p.F107C	DNHD1_uc001mdp.2_Missense_Mutation_p.F107C	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	107					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TTGCTGCCCTTCCTGGAGCAG	0.567													6	306					0	0	0	0	G	6519765	G	G	6519765	3	3	36	1	0	0	0	0	1	0	0	0	4690	1783	62	5	322	5	DNHD1	11	6519765	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	818534	6519765	128486751	575	7375											
DNHD1	144132	broad.mit.edu	37	chr11	6587845	6587845	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgaactgctaaaggggctGaatgtgttggatctgggcct	8	12	15	6	0	1	2	0	2	1	0	1	3	1	3	1	4	2	3	1	4	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:6587845G>C	uc001mdw.3	+	35	11799	c.11235G>C	c.(11233-11235)CTG>CTC	p.L3745L	DNHD1_uc001mea.3_Silent_p.L14L|DNHD1_uc001meb.2_Silent_p.L13L|DNHD1_uc001mec.2_Silent_p.L13L|DNHD1_uc010rao.1_Silent_p.L13L|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	3745					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TAAAGGGGCTGAATGTGTTGG	0.512													9	28					0	0	0	0	C	6587845	C	C	6587845	2	2	36	1	0	0	0	0	0	0	0	1	4690	1277	45	2		2	DNHD1	11	6587845	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	68080	6587845	128418671	576	7376											
OR10A5	144124	broad.mit.edu	37	chr11	6866955	6866955	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaataagtgaatttatcctCatgagcttctcttccctacc	11	14	5	11	0	2	2	1	2	1	0	5	3	4	2	3	0	2	1	3	0	5	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:6866955C>T	uc001met.1	+	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AATTTATCCTCATGAGCTTCT	0.413													7	484					0	0	0	0	T	6866955	T	T	6866955	2	4	36	1	0	0	0	0	0	0	0	1	10947	813	29	2		2	OR10A5	11	6866955	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	279110	6866955	128139561	577	7377											
OR10A5	144124	broad.mit.edu	37	chr11	6867662	6867662	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcacacctccttgttgtctCtcttttctatatatcttcta	6	20	2	13	0	6	0	1	0	5	0	8	0	7	0	2	0	0	1	2	0	4	9			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:6867662C>G	uc001met.1	+	1	749	c.749C>G	c.(748-750)TCT>TGT	p.S250C		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTTGTTGTCTCTCTTTTCTAT	0.423													102	310					0	0	0	0	G	6867662	G	G	6867662	3	3	36	1	0	0	0	0	1	0	0	0	10947	913	32	2	751	2	OR10A5	11	6867662	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	707	6867662	128138854	578	7378											
RBMXL2	27288	broad.mit.edu	37	chr11	7111102	7111102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccactccagtgtccgggacGactgtcccttgagaggctac	7	8	12	14	2	0	1	0	1	0	1	3	4	3	2	4	2	1	1	4	2	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:7111102G>A	uc001mfc.2	+	1	938	c.751G>A	c.(751-753)GAC>AAC	p.D251N		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	251	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGTCCGGGACGACTGTCCCTT	0.642													13	28					0	0	0	0	A	7111102	A	A	7111102	3	1	36	1	0	0	0	0	1	0	0	0	13219	1058	37	1	753	1	RBMXL2	11	7111102	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	243440	7111102	127895414	579	7379											
MICAL2	9645	broad.mit.edu	37	chr11	12183923	12183923	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caaattggataagcgtggttCccacaaagagtataagcgag	15	8	11	7	2	0	1	0	0	0	1	1	3	1	2	1	2	2	2	1	2	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:12183923C>T	uc001mjz.2	+	3	509	c.221C>T	c.(220-222)TCC>TTC	p.S74F	MICAL2_uc010rch.1_Missense_Mutation_p.S74F|MICAL2_uc001mjy.2_Missense_Mutation_p.S74F|MICAL2_uc001mka.2_Missense_Mutation_p.S74F|MICAL2_uc010rci.1_Missense_Mutation_p.S74F|MICAL2_uc001mkb.2_Missense_Mutation_p.S74F|MICAL2_uc001mkc.2_Missense_Mutation_p.S74F	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	74						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		AAGCGTGGTTCCCACAAAGAG	0.502													11	49					0	0	0	0	T	12183923	T	T	12183923	3	4	36	1	0	0	0	0	1	0	0	0	9623	855	30	2	223	2	MICAL2	11	12183923	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5072821	12183923	122822593	580	7380											
HPS5	11234	broad.mit.edu	37	chr11	18318449	18318449	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agagggtttggctgtgaaggGagcaagagtcttcatctgac	10	10	15	6	0	3	4	1	2	2	2	3	5	3	5	0	3	1	3	0	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:18318449G>C	uc001mod.1	-	12	1684	c.1406C>G	c.(1405-1407)TCC>TGC	p.S469C	HPS5_uc001moe.1_Missense_Mutation_p.S355C|HPS5_uc001mof.1_Missense_Mutation_p.S355C	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	469						cytosol				ovary(1)|pancreas(1)|skin(1)	3						GCTGTGAAGGGAGCAAGAGTC	0.418									Hermansky-Pudlak_syndrome				64	181					0	0	0	0	C	18318449	C	C	18318449	3	2	36	1	0	0	0	0	1	0	0	0	7381	1174	41	2	2031	2	HPS5	11	18318449	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	6134526	18318449	116688067	581	7381											
SPTY2D1	144108	broad.mit.edu	37	chr11	18655767	18655767	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcacattgttgacaccttgtCccttggaagctatcatgaga	10	12	9	10	0	1	2	1	2	0	1	2	4	2	3	2	1	1	3	2	1	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:18655767C>G	uc001moy.2	-	1	254	c.38G>C	c.(37-39)GGA>GCA	p.G13A	SPTY2D1_uc010rdi.1_Missense_Mutation_p.G13A	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	13										breast(1)	1						GACACCTTGTCCCTTGGAAGC	0.547													72	269					0	0	0	0	G	18655767	G	G	18655767	3	3	36	1	0	0	0	0	1	0	0	0	15192	855	30	2	2043	2	SPTY2D1	11	18655767	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	337318	18655767	116350749	582	7382											
MRGPRX1	259249	broad.mit.edu	37	chr11	18955404	18955404	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgacagctccaggatttcctCaggaagctgccctccacctt	8	9	8	16	1	1	0	1	0	0	0	4	3	4	2	5	2	3	2	5	2	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:18955404C>G	uc001mpg.2	-	1	1146	c.928G>C	c.(928-930)GAG>CAG	p.E310Q		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	310	Cytoplasmic (Potential).			EEI -> QET (in Ref. 2; AAL86880).	acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						AGGATTTCCTCAGGAAGCTGC	0.572													40	83					0	0	0	0	G	18955404	G	G	18955404	3	3	36	1	0	0	0	0	1	0	0	0	9819	835	29	2	44	2	MRGPRX1	11	18955404	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	299637	18955404	116051112	583	7383											
MRGPRX1	259249	broad.mit.edu	37	chr11	18956074	18956074	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtatgggggatactgatgaaGcttaacagggaatatataag	15	10	13	3	0	0	2	0	2	0	0	0	4	0	4	0	3	3	2	0	3	8	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:18956074G>T	uc001mpg.2	-	1	476	c.258C>A	c.(256-258)AGC>AGA	p.S86R		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	86	Helical; Name=2; (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						TACTGATGAAGCTTAACAGGG	0.522													46	135					4.21674e-32	4.54339e-32	1	0	T	18956074	T	T	18956074	3	4	36	1	0	0	0	0	1	0	0	0	9819	962	34	4	714	4	MRGPRX1	11	18956074	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	670	18956074	116050442	584	7384											
SLC6A5	9152	broad.mit.edu	37	chr11	20658825	20658825	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctgcatttgtttcttcatCatgggttttccaatgatcac	7	18	7	9	0	4	1	3	1	1	0	5	1	5	1	1	1	2	4	1	1	1	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:20658825C>G	uc001mqd.2	+	12	2118	c.1845C>G	c.(1843-1845)ATC>ATG	p.I615M	SLC6A5_uc009yic.2_Missense_Mutation_p.I380M	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	615	Helical; Name=9; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	GTTTCTTCATCATGGGTTTTC	0.532													32	85					0	0	0	0	G	20658825	G	G	20658825	3	3	36	1	0	0	0	0	1	0	0	0	14751	816	29	2	1891	2	SLC6A5	11	20658825	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1702751	20658825	114347691	585	7385											
SLC5A12	159963	broad.mit.edu	37	chr11	26700349	26700349	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagatcgagtaccaggtatCagctattccaggtctgtgga	10	10	13	8	1	2	1	1	0	1	1	4	4	3	2	2	4	2	3	2	4	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:26700349C>T	uc001mra.2	-	13	1802	c.1489G>A	c.(1489-1491)GAT>AAT	p.D497N	SLC5A12_uc001mrb.2_RNA	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	497	Extracellular (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						TACCAGGTATCAGCTATTCCA	0.468													25	81					0	0	0	0	T	26700349	T	T	26700349	3	4	36	1	0	0	0	0	1	0	0	0	14728	826	29	2	379	2	SLC5A12	11	26700349	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6041524	26700349	108306167	586	7386											
KIF18A	81930	broad.mit.edu	37	chr11	28045380	28045380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatttacgtctgcagttaacGaactgtttgatgtagaactt	12	15	8	6	2	1	2	0	1	1	1	1	3	1	2	0	0	5	4	0	0	6	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:28045380G>A	uc001msc.2	-	16	2704	c.2522C>T	c.(2521-2523)TCG>TTG	p.S841L		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	841					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						TGCAGTTAACGAACTGTTTGA	0.328													23	73					0	0	0	0	A	28045380	A	A	28045380	3	1	36	1	0	0	0	0	1	0	0	0	8319	1059	37	1	182	1	KIF18A	11	28045380	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1345031	28045380	106961136	587	7387											
KCNA4	3739	broad.mit.edu	37	chr11	30033388	30033388	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcggggagggccctgtcttCctcttctctcacaaagccct	5	11	9	16	1	4	0	1	0	3	0	7	1	5	1	3	3	1	0	3	3	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:30033388C>T	uc001msk.2	-	2	1990	c.838G>A	c.(838-840)GAA>AAA	p.E280K		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	280						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCCCTGTCTTCCTCTTCTCTC	0.507													32	95					0	0	0	0	T	30033388	T	T	30033388	3	4	36	1	0	0	0	0	1	0	0	0	8044	864	30	2	1127	2	KCNA4	11	30033388	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1988008	30033388	104973128	588	7388											
DCDC1	341019	broad.mit.edu	37	chr11	31312293	31312293	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggtcctctcagtaagtttCttcattctaatagaaagaac	13	13	7	8	0	4	2	2	0	3	2	6	3	5	2	1	1	1	2	1	1	5	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:31312293C>T	uc001msv.2	-	7	1063	c.861G>A	c.(859-861)AAG>AAA	p.K287K	DCDC1_uc001msu.1_Intron	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	287					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					CAGTAAGTTTCTTCATTCTAA	0.388													38	94					0	0	0	0	T	31312293	T	T	31312293	2	4	36	1	0	0	0	0	0	0	0	1	4301	912	32	2		2	DCDC1	11	31312293	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1278905	31312293	103694223	589	7389											
CCDC73	493860	broad.mit.edu	37	chr11	32676499	32676499	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttggactttatcaagtctGaggctgctttttttagttcc	6	19	8	8	0	2	1	1	1	1	0	3	2	3	2	1	2	1	3	1	2	3	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:32676499G>C	uc001mtv.2	-	10	709	c.665C>G	c.(664-666)TCA>TGA	p.S222*	CCDC73_uc001mtw.1_Nonsense_Mutation_p.S222*	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	222										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TATCAAGTCTGAGGCTGCTTT	0.299													17	48					0	0	0	0	C	32676499	C	C	32676499	4	2	36	1	0	0	0	0	0	1	0	0	2859	1294	45	2	2610	2	CCDC73	11	32676499	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1364206	32676499	102330017	590	7390											
PRDM11	56981	broad.mit.edu	37	chr11	45241142	45241142	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacgtggtcatctcccgggaGgagagggagcagaacctgct	9	7	15	10	2	2	2	1	0	1	2	3	5	2	4	2	4	4	2	2	4	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:45241142G>C	uc001myo.2	+	7	927	c.678G>C	c.(676-678)GAG>GAC	p.E226D		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	226	SET.									upper_aerodigestive_tract(1)	1						TCTCCCGGGAGGAGAGGGAGC	0.662													20	45					0	0	0	0	C	45241142	C	C	45241142	3	2	36	1	0	0	0	0	1	0	0	0	12514	991	35	4	700	4	PRDM11	11	45241142	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	12564643	45241142	89765374	591	7391											
CKAP5	9793	broad.mit.edu	37	chr11	46801864	46801864	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggttatggcagcagtcctCacagcctgccagacagaaga	12	6	12	11	0	1	3	1	0	0	3	2	3	2	3	3	2	3	3	3	2	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:46801864C>G	uc001ndi.1	-	20	2423	c.2313G>C	c.(2311-2313)GTG>GTC	p.V771V	CKAP5_uc009ylg.1_Silent_p.V657V|CKAP5_uc001ndj.1_Silent_p.V771V	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	771	HEAT 4.				cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CAGCAGTCCTCACAGCCTGCC	0.418													12	42					0	0	0	0	G	46801864	G	G	46801864	2	3	36	1	0	0	0	0	0	0	0	1	3460	813	29	2		2	CKAP5	11	46801864	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1560722	46801864	88204652	592	7392											
C11orf49	79096	broad.mit.edu	37	chr11	47176813	47176813	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatccagttttactactcagGtgagtgttccggggctccat	7	13	11	10	1	1	1	1	1	0	0	4	2	4	1	3	3	2	3	3	3	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:47176813G>A	uc001ndp.2	+	5	557	c.451_splice	c.e5+1	p.E151_splice	C11orf49_uc001nds.2_Splice_Site_p.E151_splice|C11orf49_uc001ndq.2_Splice_Site_p.E151_splice|C11orf49_uc001ndr.2_Splice_Site_p.E151_splice|C11orf49_uc010rgx.1_Splice_Site_p.E54_splice|C11orf49_uc010rgy.1_Splice_Site_p.E142_splice|C11orf49_uc010rgz.1_Splice_Site_p.E67_splice	NM_024113	NP_077018	Q9H6J7	CK049_HUMAN	hypothetical protein LOC79096 isoform 3												0						TACTACTCAGGTGAGTGTTCC	0.542													64	217					0	0	0	0	A	47176813	A	A	47176813	5	1	36	1	0	0	0	0	0	0	1	0	1651	1275	44	4	470	4	C11orf49	11	47176813	Splice_Site	SNP	G	TCGA-CN-4723-01A-01D-1434-08	374949	47176813	87829703	593	7393											
AGBL2	79841	broad.mit.edu	37	chr11	47684621	47684621	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagaatcagggtggccattGatgggtccaggggggtgtct	7	9	18	7	0	2	2	1	1	1	1	3	2	3	2	2	6	0	1	2	6	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:47684621G>A	uc001ngg.2	-	17	2592	c.2492C>T	c.(2491-2493)TCA>TTA	p.S831L	AGBL2_uc001ngf.2_RNA	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic	831					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						GGTGGCCATTGATGGGTCCAG	0.353													106	325					0	0	0	0	A	47684621	A	A	47684621	3	1	36	1	0	0	0	0	1	0	0	0	376	1294	45	2	224	2	AGBL2	11	47684621	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	507808	47684621	87321895	594	7394											
NUP160	23279	broad.mit.edu	37	chr11	47819408	47819408	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtcataaggtccacagctCtagcacgtgactcaattatt	12	11	8	10	1	3	1	2	1	1	0	4	2	4	1	1	1	2	2	1	1	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:47819408C>G	uc001ngm.2	-	27	3297	c.3212G>C	c.(3211-3213)AGA>ACA	p.R1071T	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	1071					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						GTCCACAGCTCTAGCACGTGA	0.438													35	138					0	0	0	0	G	47819408	G	G	47819408	3	3	36	1	0	0	0	0	1	0	0	0	10811	913	32	2	1138	2	NUP160	11	47819408	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	134787	47819408	87187108	595	7395											
OR4A15	81328	broad.mit.edu	37	chr11	55135371	55135371	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttttgacatggagcttctGacaaataatctcaaatttat	14	16	5	6	0	2	2	1	2	2	0	3	3	2	3	0	1	1	1	0	1	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:55135371G>A	uc010rif.1	+	1	12	c.12G>A	c.(10-12)CTG>CTA	p.L4L		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	4	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGGAGCTTCTGACAAATAATC	0.408													21	66					0	0	0	0	A	55135371	A	A	55135371	2	1	36	1	0	0	0	0	0	0	0	1	11094	1277	45	2		2	OR4A15	11	55135371	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	7315963	55135371	79871145	596	7396											
OR5L1	219437	broad.mit.edu	37	chr11	55579557	55579557	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgttcctggtggccactttGaatgagagtgttaccatcat	8	14	10	9	0	1	2	1	2	0	1	2	3	2	2	3	2	1	2	3	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:55579557G>A	uc001nhw.1	+	1	615	c.615G>A	c.(613-615)TTG>TTA	p.L205L		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TGGCCACTTTGAATGAGAGTG	0.468													71	229					0	0	0	0	A	55579557	A	A	55579557	2	1	36	1	0	0	0	0	0	0	0	1	11224	1281	45	2		2	OR5L1	11	55579557	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	444186	55579557	79426959	597	7397											
SPRYD5	84767	broad.mit.edu	37	chr11	55659078	55659078	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctccttctcacctcctctCaggcctatcttttgctgtag	4	16	6	15	0	3	0	2	0	3	0	7	0	5	0	4	1	2	3	4	1	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:55659078C>T	uc010rip.1	+	7	1421	c.1329C>T	c.(1327-1329)CTC>CTT	p.L443L	SPRYD5_uc010riq.1_Silent_p.L300L	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	443	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CACCTCCTCTCAGGCCTATCT	0.453													51	266					0	0	0	0	T	55659078	T	T	55659078	2	4	36	1	0	0	0	0	0	0	0	1	15177	813	29	2		2	SPRYD5	11	55659078	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	79521	55659078	79347438	598	7398											
OR8H2	390151	broad.mit.edu	37	chr11	55872928	55872928	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acactacacagttattatgtCcaaaaggctctgcctcgctc	11	11	6	13	1	1	0	0	0	1	0	4	0	2	0	2	1	2	3	2	1	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:55872928C>T	uc010riy.1	+	1	410	c.410C>T	c.(409-411)TCC>TTC	p.S137F		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					GTTATTATGTCCAAAAGGCTC	0.468										HNSCC(53;0.14)			116	280					0	0	0	0	T	55872928	T	T	55872928	3	4	36	1	0	0	0	0	1	0	0	0	11292	855	30	2	412	2	OR8H2	11	55872928	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	213850	55872928	79133588	599	7399											
TNKS1BP1	85456	broad.mit.edu	37	chr11	57080763	57080763	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgataagctccagttggactCtgccccaaagggacgatcca	11	8	10	12	1	1	1	0	1	1	0	3	4	3	3	4	2	2	2	4	2	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:57080763C>G	uc001njr.2	-	4	1711	c.1399G>C	c.(1399-1401)GAG>CAG	p.E467Q	TNKS1BP1_uc001njs.2_Missense_Mutation_p.E467Q|TNKS1BP1_uc009ymd.1_5'UTR	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	467	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				CAGTTGGACTCTGCCCCAAAG	0.672													21	42					0	0	0	0	G	57080763	G	G	57080763	3	3	36	1	0	0	0	0	1	0	0	0	16386	922	32	2	3818	2	TNKS1BP1	11	57080763	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1207835	57080763	77925753	600	7400											
OR1S1	219959	broad.mit.edu	37	chr11	57982933	57982933	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcatcatcagagctgtcctGagagtatcttccacacaggg	10	10	10	11	0	3	2	2	1	1	2	5	3	5	2	2	1	2	3	2	1	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:57982933G>A	uc010rkc.1	+	1	717	c.717G>A	c.(715-717)CTG>CTA	p.L239L		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	239	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				GAGCTGTCCTGAGAGTATCTT	0.438													42	75					0	0	0	0	A	57982933	A	A	57982933	2	1	36	1	0	0	0	0	0	0	0	1	11026	1277	45	2		2	OR1S1	11	57982933	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	902170	57982933	77023583	601	7401											
MTA2	9219	broad.mit.edu	37	chr11	62364201	62364201	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgaccattcctccatctCatcccgacacagcaccgggc	8	7	8	18	2	1	1	1	1	1	0	5	2	4	1	5	2	1	2	5	2	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:62364201C>A	uc001ntq.1	-	9	1171	c.790G>T	c.(790-792)GAG>TAG	p.E264*	MTA2_uc010rlx.1_Nonsense_Mutation_p.E91*	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	264	SANT.				chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCCTCCATCTCATCCCGACAC	0.537													54	110					9.55421e-19	1.01425e-18	1	0	A	62364201	A	A	62364201	4	1	36	1	0	0	0	0	0	1	0	0	9962	835	29	2	1256	2	MTA2	11	62364201	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4381268	62364201	72642315	602	7402											
UBXN1	51035	broad.mit.edu	37	chr11	62444320	62444320	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccgctccatgtcagcttctGagaaggcccgtctggggaag	7	8	14	12	2	3	1	1	1	2	1	4	3	4	2	3	3	1	2	3	3	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:62444320G>C	uc001nul.1	-	8	941	c.809C>G	c.(808-810)TCA>TGA	p.S270*	UBXN1_uc001nuj.2_Nonsense_Mutation_p.S270*|UBXN1_uc001num.1_Nonsense_Mutation_p.S266*|UBXN1_uc001nuk.2_3'UTR|UBXN1_uc010rme.1_3'UTR	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	270	UBX.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						GTCAGCTTCTGAGAAGGCCCG	0.592													62	187					0	0	0	0	C	62444320	C	C	62444320	4	2	36	1	0	0	0	0	0	1	0	0	16979	1294	45	2	133	2	UBXN1	11	62444320	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	80119	62444320	72562196	603	7403											
SLC22A10	387775	broad.mit.edu	37	chr11	63072312	63072312	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttattgtcttcctcctaccaGaaaccaagaatctgcctttg	10	14	5	12	0	2	2	0	0	2	2	4	2	4	2	5	0	3	0	5	0	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:63072312G>C	uc009yor.2	+	9	1757	c.1549G>C	c.(1549-1551)GAA>CAA	p.E517Q	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_3'UTR	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	517	Extracellular (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						CCTCCTACCAGAAACCAAGAA	0.433													51	208					0	0	0	0	C	63072312	C	C	63072312	3	2	36	1	0	0	0	0	1	0	0	0	14506	943	33	2	1583	2	SLC22A10	11	63072312	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	627992	63072312	71934204	604	7404											
SLC22A11	55867	broad.mit.edu	37	chr11	64323848	64323848	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgaccgcagcgtcttcacctCcaccatcgtggccaaggtag	8	8	10	15	3	2	1	1	1	1	0	4	1	3	1	5	2	1	2	5	2	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:64323848C>G	uc001oai.2	+	1	751	c.377C>G	c.(376-378)TCC>TGC	p.S126C	SLC22A11_uc001oah.1_Missense_Mutation_p.S126C|SLC22A11_uc001oaj.2_Missense_Mutation_p.S126C|SLC22A11_uc009ypq.2_Missense_Mutation_p.S126C	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	126	Extracellular (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	GTCTTCACCTCCACCATCGTG	0.627													14	36					0	0	0	0	G	64323848	G	G	64323848	3	3	36	1	0	0	0	0	1	0	0	0	14507	855	30	2	379	2	SLC22A11	11	64323848	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1251536	64323848	70682668	605	7405											
ZFPL1	7542	broad.mit.edu	37	chr11	64853913	64853913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcactgggcctgcctcaatGaacgtgctgcccagctaccc	7	9	9	16	1	2	1	2	1	0	0	2	1	2	1	4	1	6	2	4	1	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:64853913G>A	uc001ocq.1	+	4	406	c.241G>A	c.(241-243)GAA>AAA	p.E81K	CDCA5_uc001ocp.2_5'Flank	NM_006782	NP_006773	O95159	ZFPL1_HUMAN	zinc finger protein-like 1	81	RING-type; degenerate.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|vesicle-mediated transport	Golgi apparatus|integral to membrane|nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTGCCTCAATGAACGTGCTGC	0.592													115	303					0	0	0	0	A	64853913	A	A	64853913	3	1	36	1	0	0	0	0	1	0	0	0	17723	1291	45	2	251	2	ZFPL1	11	64853913	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	530065	64853913	70152603	606	7406											
KDM2A	22992	broad.mit.edu	37	chr11	66985207	66985207	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttttaactcacaggtcttCtggctcatcccccctacagc	7	14	5	15	0	4	0	2	0	2	0	5	0	5	0	3	2	3	1	3	2	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:66985207C>T	uc001ojw.2	+	9	1557	c.693C>T	c.(691-693)TTC>TTT	p.F231F	KDM2A_uc001ojx.2_RNA|KDM2A_uc001ojy.2_Intron	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	231	JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						CACAGGTCTTCTGGCTCATCC	0.483													7	33					0	0	0	0	T	66985207	T	T	66985207	2	4	36	1	0	0	0	0	0	0	0	1	8163	912	32	2		2	KDM2A	11	66985207	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2131294	66985207	68021309	607	7407											
CPT1A	1374	broad.mit.edu	37	chr11	68575046	68575046	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacgatgagggccacccaCaggccggtgccaaacagcac	11	3	13	14	2	0	2	0	2	0	0	0	3	0	2	4	3	3	1	4	3	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:68575046C>G	uc001oog.3	-	4	512	c.342G>C	c.(340-342)CTG>CTC	p.L114L	CPT1A_uc001oof.3_Silent_p.L114L|CPT1A_uc009ysj.2_Silent_p.L114L	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	114	Helical; (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GGGCCACCCACAGGCCGGTGC	0.607													14	56					0	0	0	0	G	68575046	G	G	68575046	2	3	36	1	0	0	0	0	0	0	0	1	3846	465	17	4		4	CPT1A	11	68575046	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1589839	68575046	66431470	608	7408											
CTTN	2017	broad.mit.edu	37	chr11	70253636	70253636	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttcagaatgatgtgagtGagaaggagcaaagatggggt	13	10	15	3	0	1	5	1	3	0	3	1	7	1	6	0	3	1	1	0	3	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:70253636G>A	uc001opv.3	+	4	306	c.100G>A	c.(100-102)GAG>AAG	p.E34K	CTTN_uc001opu.2_Missense_Mutation_p.E34K|CTTN_uc001opw.3_Missense_Mutation_p.E34K	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	34						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		TGATGTGAGTGAGAAGGAGCA	0.552													34	135					0	0	0	0	A	70253636	A	A	70253636	3	1	36	1	0	0	0	0	1	0	0	0	4061	1291	45	2	106	2	CTTN	11	70253636	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1678590	70253636	64752880	609	7409											
FCHSD2	9873	broad.mit.edu	37	chr11	72712082	72712082	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcactgtccttgcaggctCagaaatgaagtttttatagt	10	15	8	8	0	2	2	2	1	1	1	4	2	3	2	1	1	1	3	1	1	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:72712082C>G	uc009ytl.2	-	5	561	c.340G>C	c.(340-342)GAG>CAG	p.E114Q	FCHSD2_uc010rrg.1_Intron|FCHSD2_uc001oth.3_Missense_Mutation_p.E58Q|FCHSD2_uc001oti.2_Missense_Mutation_p.E73Q	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	114							protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			CTTGCAGGCTCAGAAATGAAG	0.368													6	21					0	0	0	0	G	72712082	G	G	72712082	3	3	36	1	0	0	0	0	1	0	0	0	5822	835	29	2	1946	2	FCHSD2	11	72712082	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2458446	72712082	62294434	610	7410											
PGM2L1	283209	broad.mit.edu	37	chr11	74053568	74053568	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcccgtacatgcaatatagCaaatgttccacaaaattttg	14	12	6	9	1	0	0	0	0	0	0	2	0	2	0	2	0	3	4	2	0	7	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:74053568C>G	uc001ovb.1	-	12	1866	c.1570G>C	c.(1570-1572)GCT>CCT	p.A524P		NM_173582	NP_775853	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	524					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			ovary(1)	1	Breast(11;3.32e-06)					TGCAATATAGCAAATGTTCCA	0.323													4	199					0	0	0	0	G	74053568	G	G	74053568	3	3	36	1	0	0	0	0	1	0	0	0	11854	710	25	4	310	4	PGM2L1	11	74053568	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1341486	74053568	60952948	611	7411											
SLCO2B1	11309	broad.mit.edu	37	chr11	74873772	74873772	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggcacagaaaacacacctgGaggcaaagccagcccagacc	15	1	11	14	0	0	2	0	0	0	2	0	3	0	3	4	3	3	2	4	3	3	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:74873772G>A	uc001owb.2	+	2	476	c.89G>A	c.(88-90)GGA>GAA	p.G30E	SLCO2B1_uc010rrp.1_RNA|SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Intron|SLCO2B1_uc010rrs.1_Intron|SLCO2B1_uc001owc.2_Intron|SLCO2B1_uc001owd.2_Missense_Mutation_p.G8E	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	30	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	AACACACCTGGAGGCAAAGCC	0.577													111	237					0	0	0	0	A	74873772	A	A	74873772	3	1	36	1	0	0	0	0	1	0	0	0	14791	1174	41	2	95	2	SLCO2B1	11	74873772	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	820204	74873772	60132744	612	7412											
RPS3	6188	broad.mit.edu	37	chr11	75111786	75111786	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aactgaatgagtttcttactCgggagctggctgaagatggc	10	11	13	7	1	1	4	0	3	1	1	2	5	1	5	0	3	3	3	0	3	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:75111786C>T	uc001owh.2	+	2	109	c.79C>T	c.(79-81)CGG>TGG	p.R27W	RPS3_uc001owg.2_Missense_Mutation_p.R27W|RPS3_uc001owi.2_Missense_Mutation_p.R27W|RPS3_uc001owk.1_5'UTR	NM_001005	NP_000996	P23396	RS3_HUMAN	ribosomal protein S3	27	KH type-2.				activation of caspase activity|endocrine pancreas development|induction of apoptosis|negative regulation of DNA repair|negative regulation of NF-kappaB transcription factor activity|response to DNA damage stimulus|translational elongation|translational initiation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleus|ruffle membrane	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|iron-sulfur cluster binding|mRNA binding|NF-kappaB binding|protein kinase binding|structural constituent of ribosome				0						GTTTCTTACTCGGGAGCTGGC	0.438													5	195					0	0	0	0	T	75111786	T	T	75111786	3	4	36	1	0	0	0	0	1	0	0	0	13708	875	31	1	85	1	RPS3	11	75111786	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	238014	75111786	59894730	613	7413											
PRKRIR	5612	broad.mit.edu	37	chr11	76062412	76062412	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctttgaggtgctgttctgaGaatatatctttaagttcctg	8	17	10	6	0	2	2	0	2	2	1	3	3	3	2	1	1	1	4	1	1	4	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:76062412G>A	uc001oxh.1	-	5	1782	c.1782C>T	c.(1780-1782)TTC>TTT	p.F594F	PRKRIR_uc010rrz.1_Silent_p.F419F	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	594					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						GCTGTTCTGAGAATATATCTT	0.418													61	143					0	0	0	0	A	76062412	A	A	76062412	2	1	36	1	0	0	0	0	0	0	0	1	12588	933	33	2		2	PRKRIR	11	76062412	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	950626	76062412	58944104	614	7414											
RSF1	51773	broad.mit.edu	37	chr11	77378293	77378293	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttggtgctctcttgttctGagggcaggaccctaggctgg	4	13	14	10	0	3	1	0	1	3	0	4	2	3	2	1	5	1	4	1	5	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:77378293G>C	uc001oyn.2	-	16	4115	c.3995C>G	c.(3994-3996)TCA>TGA	p.S1332*	RSF1_uc001oym.2_Nonsense_Mutation_p.S1080*	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	1332					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			CTCTTGTTCTGAGGGCAGGAC	0.522													61	153					0	0	0	0	C	77378293	C	C	77378293	4	2	36	1	0	0	0	0	0	1	0	0	13764	1294	45	2	334	2	RSF1	11	77378293	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1315881	77378293	57628223	615	7415											
KCTD21	283219	broad.mit.edu	37	chr11	77884871	77884871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcataaaatccagagcatGtgggtgagaagaatcgatgc	14	9	12	6	1	1	3	1	1	0	3	3	5	2	3	1	1	2	2	1	1	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:77884871G>A	uc001ozb.2	-	2	805	c.730C>T	c.(730-732)CAT>TAT	p.H244Y		NM_001029859	NP_001025030	Q4G0X4	KCD21_HUMAN	potassium channel tetramerisation domain	244						voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.46e-24)			TCCAGAGCATGTGGGTGAGAA	0.478													66	241					0	0	0	0	A	77884871	A	A	77884871	3	1	36	1	0	0	0	0	1	0	0	0	8148	1377	48	4	56	4	KCTD21	11	77884871	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	506578	77884871	57121645	616	7416											
ME3	10873	broad.mit.edu	37	chr11	86160950	86160950	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttgacaatgagccctttaGagtccaccatccagatcttt	10	12	6	13	0	1	4	0	2	1	2	3	4	3	4	5	0	1	0	5	0	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:86160950G>C	uc001pbz.2	-	9	1366	c.1112C>G	c.(1111-1113)TCT>TGT	p.S371C	ME3_uc001pca.2_Missense_Mutation_p.S371C|ME3_uc009yvk.2_Missense_Mutation_p.S371C|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	371					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	GAGCCCTTTAGAGTCCACCAT	0.522													75	160					0	0	0	0	C	86160950	C	C	86160950	3	2	36	1	0	0	0	0	1	0	0	0	9472	942	33	2	726	2	ME3	11	86160950	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	8276079	86160950	48845566	617	7417											
CCDC67	159989	broad.mit.edu	37	chr11	93127665	93127665	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtggaagagtaccataactCtgagcaggaaagaatgagga	16	6	14	5	0	1	4	0	2	1	2	1	7	1	7	1	4	3	2	1	4	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:93127665C>G	uc001pdq.2	+	10	1182	c.1082C>G	c.(1081-1083)TCT>TGT	p.S361C	CCDC67_uc001pdo.1_Missense_Mutation_p.S361C|CCDC67_uc001pdp.2_Missense_Mutation_p.S361C	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	361	Potential.									ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TACCATAACTCTGAGCAGGAA	0.393													9	13					0	0	0	0	G	93127665	G	G	93127665	3	3	36	1	0	0	0	0	1	0	0	0	2852	913	32	2	1116	2	CCDC67	11	93127665	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6966715	93127665	41878851	618	7418											
MED17	9440	broad.mit.edu	37	chr11	93523943	93523943	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gataaaattctcggagatctGagctacagaagtgcaggtat	14	10	11	6	1	2	3	0	1	2	2	3	5	2	3	0	2	3	3	0	2	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:93523943G>A	uc001pem.3	+	3	896	c.621G>A	c.(619-621)CTG>CTA	p.L207L		NM_004268	NP_004259	Q9NVC6	MED17_HUMAN	mediator complex subunit 17	207					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TCGGAGATCTGAGCTACAGAA	0.264													16	69					0	0	0	0	A	93523943	A	A	93523943	2	1	36	1	0	0	0	0	0	0	0	1	9488	1277	45	2		2	MED17	11	93523943	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	396278	93523943	41482573	619	7419											
CNTN5	53942	broad.mit.edu	37	chr11	99786823	99786823	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccggacaagaagtgcagtCtctgtgagggaaggccaggg	10	5	18	8	1	1	2	0	1	1	1	2	4	1	4	2	5	1	1	2	5	3	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:99786823C>T	uc001pga.2	+	7	954	c.615C>T	c.(613-615)GTC>GTT	p.V205V	CNTN5_uc009ywv.1_Silent_p.V205V|CNTN5_uc001pfz.2_Silent_p.V205V|CNTN5_uc001pgb.2_Silent_p.V131V	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	205	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GAAGTGCAGTCTCTGTGAGGG	0.453													10	25					0	0	0	0	T	99786823	T	T	99786823	2	4	36	1	0	0	0	0	0	0	0	1	3659	900	32	2		2	CNTN5	11	99786823	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6262880	99786823	35219693	620	7420											
DDI1	414301	broad.mit.edu	37	chr11	103908514	103908514	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgctctttctccatacttGaggatcaacccatggatatg	10	13	8	10	0	3	1	1	1	2	0	4	3	3	3	2	2	3	1	2	2	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:103908514G>A	uc001phr.2	+	1	1207	c.964G>A	c.(964-966)GAG>AAG	p.E322K	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	322					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CTCCATACTTGAGGATCAACC	0.448													47	156					0	0	0	0	A	103908514	A	A	103908514	3	1	36	1	0	0	0	0	1	0	0	0	4345	1291	45	2	966	2	DDI1	11	103908514	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4121691	103908514	31098002	621	7421											
TMPRSS5	80975	broad.mit.edu	37	chr11	113563881	113563881	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggggtgtgggataatcctCtccaccagagccccttggtg	7	9	14	11	0	1	1	0	0	1	1	3	2	2	2	5	4	1	0	5	4	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:113563881C>G	uc001poc.3	-	9	998	c.876G>C	c.(874-876)GAG>GAC	p.E292D	TMPRSS5_uc009yys.2_Missense_Mutation_p.E283D|TMPRSS5_uc009yyt.2_Missense_Mutation_p.E248D|TMPRSS5_uc001pod.3_Missense_Mutation_p.E33D|TMPRSS5_uc010rww.1_Missense_Mutation_p.E213D|TMPRSS5_uc009yyu.2_Missense_Mutation_p.E33D|TMPRSS5_uc010rwx.1_Missense_Mutation_p.E179D	NM_030770	NP_110397	Q9H3S3	TMPS5_HUMAN	transmembrane protease, serine 5	292	Peptidase S1.|Extracellular (Potential).				proteolysis	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(1)	1		all_cancers(61;2.71e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.75e-06)|Epithelial(105;6.34e-05)|all cancers(92;0.000502)		GGATAATCCTCTCCACCAGAG	0.637													6	9					0	0	0	0	G	113563881	G	G	113563881	3	3	36	1	0	0	0	0	1	0	0	0	16316	912	32	2	517	2	TMPRSS5	11	113563881	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	9655367	113563881	21442635	622	7422											
HTR3B	9177	broad.mit.edu	37	chr11	113816676	113816676	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggaaccctgaaggaagtCtggtcgcagcttcaatctat	11	9	10	11	1	3	1	1	1	2	0	4	3	3	3	2	3	2	2	2	3	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:113816676C>T	uc001pok.2	+	9	1210	c.1143C>T	c.(1141-1143)GTC>GTT	p.V381V	HTR3B_uc001pol.2_Silent_p.V370V	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	381	Cytoplasmic (Potential).|HA-stretch.				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TGAAGGAAGTCTGGTCGCAGC	0.572													23	56					0	0	0	0	T	113816676	T	T	113816676	2	4	36	1	0	0	0	0	0	0	0	1	7484	900	32	2		2	HTR3B	11	113816676	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	252795	113816676	21189840	623	7423											
SIK3	23387	broad.mit.edu	37	chr11	116730264	116730264	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaacagttctcaggttgctGctgaaagattgcactgcggg	9	10	14	8	1	1	2	1	1	1	1	2	3	1	3	0	3	5	5	0	3	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:116730264G>A	uc001ppy.2	-	19	2200	c.2164C>T	c.(2164-2166)CAG>TAG	p.Q722*	SIK3_uc001ppz.2_Nonsense_Mutation_p.Q621*|SIK3_uc001pqa.2_Nonsense_Mutation_p.Q722*|SIK3_uc001ppw.2_Nonsense_Mutation_p.Q139*|SIK3_uc001ppx.2_Nonsense_Mutation_p.Q160*|SIK3_uc001pqb.2_Nonsense_Mutation_p.Q25*	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	722	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						TCAGGTTGCTGCTGAAAGATT	0.552											OREG0003491	type=REGULATORY REGION|Gene=AK022302|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	29	104					0	0	0	0	A	116730264	A	A	116730264	4	1	36	1	0	0	0	0	0	1	0	0	14384	1328	46	4	1647	4	SIK3	11	116730264	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2913588	116730264	18276252	624	7424											
PCSK7	9159	broad.mit.edu	37	chr11	117098989	117098989	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcatccactaccaccacCgtcacccctcgcccagtcac	8	6	4	23	3	3	0	3	0	0	0	5	0	4	0	8	0	1	0	8	0	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:117098989C>T	uc001pqr.2	-	4	747	c.546G>A	c.(544-546)ACG>ACA	p.T182T		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	182	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		CTACCACCACCGTCACCCCTC	0.582			T	IGH@	MLCLS								12	24					0	0	0	0	T	117098989	T	T	117098989	2	4	36	1	0	0	0	0	0	0	0	1	11659	639	23	1		1	PCSK7	11	117098989	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	368725	117098989	17907527	625	7425											
CD3D	915	broad.mit.edu	37	chr11	118210614	118210614	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatccagctccacacagctCtggcacactgtgggggaagg	9	6	14	12	0	1	0	0	0	1	0	3	2	3	2	2	5	2	3	2	5	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:118210614C>G	uc001pss.1	-	3	419	c.282G>C	c.(280-282)CAG>CAC	p.Q94H	CD3D_uc001pst.1_Intron	NM_000732	NP_000723	P04234	CD3D_HUMAN	CD3 antigen, delta subunit isoform A precursor	94	Extracellular (Potential).				positive thymic T cell selection|T cell costimulation|T cell receptor signaling pathway	cytoplasm|integral to membrane	protein heterodimerization activity			ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		CCACACAGCTCTGGCACACTG	0.547													21	74					0	0	0	0	G	118210614	G	G	118210614	3	3	36	1	0	0	0	0	1	0	0	0	3025	912	32	2	245	2	CD3D	11	118210614	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1111625	118210614	16795902	626	7426											
PHLDB1	23187	broad.mit.edu	37	chr11	118499169	118499169	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctgagcccagcctacagtCtgggctctcttactggggct	5	10	13	13	0	2	1	0	1	2	0	3	1	2	1	2	4	4	3	2	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:118499169C>T	uc001ptr.1	+	7	1983	c.1630C>T	c.(1630-1632)CTG>TTG	p.L544L	PHLDB1_uc001pts.2_Silent_p.L544L|PHLDB1_uc001ptt.2_Silent_p.L544L|PHLDB1_uc001ptu.1_Intron|PHLDB1_uc001ptv.1_Silent_p.L344L|PHLDB1_uc001ptw.1_5'Flank	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	544											0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		AGCCTACAGTCTGGGCTCTCT	0.642													11	24					0	0	0	0	T	118499169	T	T	118499169	2	4	36	1	0	0	0	0	0	0	0	1	11906	912	32	2		2	PHLDB1	11	118499169	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	288555	118499169	16507347	627	7427											
DPAGT1	1798	broad.mit.edu	37	chr11	118971068	118971069	+	Frame_Shift_Ins	INS	-	A	A																															cctgctaggatattgatggcINSattggtacagaacactgcca																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:118971068_118971069insA	uc001pvi.2	-	4	966_967	c.546_547insT	c.(544-549)AATGCCfs	p.N182fs	DPAGT1_uc001pvj.2_Frame_Shift_Ins_p.N75fs|DPAGT1_uc009zaq.2_RNA|DPAGT1_uc001pvk.2_Frame_Shift_Ins_p.N10fs|DPAGT1_uc010ryz.1_Frame_Shift_Ins_p.N182fs|DPAGT1_uc001pvm.1_Frame_Shift_Ins_p.N75fs|DPAGT1_uc010rza.1_Frame_Shift_Ins_p.N75fs	NM_001382	NP_001373	Q9H3H5	GPT_HUMAN	UDP-N-acetylglucosamine-dolichyl-phosphate	182_183	Helical; (Potential).				dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity			breast(2)|ovary(1)	3	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		ATATTGATGGCATTGGTACAGA	0.5											OREG0021396	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								A	118971069	A	A	118971068	7	5	36	1	0	1	1	0	0	0	0	0	4732	710	25	0	703	0	DPAGT1	11	118971068	Frame_Shift_Ins	INS	-	TCGA-CN-4723-01A-01D-1434-08	471899	118971068	16035448	628	7428											
MCAM	4162	broad.mit.edu	37	chr11	119185721	119185721	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccctggccctggcgcacacgGaagatgagcgtccgcttctc	6	7	12	16	4	1	2	0	1	1	1	3	3	2	3	3	3	1	2	3	3	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:119185721G>A	uc001pwf.2	-	3	251	c.222C>T	c.(220-222)TTC>TTT	p.F74F		NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	74	Extracellular (Potential).|Ig-like V-type 1.				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		GGCGCACACGGAAGATGAGCG	0.647													56	156					0	0	0	0	A	119185721	A	A	119185721	2	1	36	1	0	0	0	0	0	0	0	1	9421	1165	41	2		2	MCAM	11	119185721	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	214653	119185721	15820795	629	7429											
VSIG2	23584	broad.mit.edu	37	chr11	124621364	124621364	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggctgcacaaagctccaCtccagggcgaagctgtctcc	9	6	10	16	1	1	0	0	0	1	0	4	1	3	0	4	2	3	4	4	2	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:124621364C>G	uc001qas.2	-	2	250	c.174G>C	c.(172-174)GAG>GAC	p.E58D	VSIG2_uc001qat.2_Missense_Mutation_p.E58D	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	58	Extracellular (Potential).|Ig-like V-type.					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		CAAAGCTCCACTCCAGGGCGA	0.627													34	112					0	0	0	0	G	124621364	G	G	124621364	3	3	36	1	0	0	0	0	1	0	0	0	17292	564	20	4	833	4	VSIG2	11	124621364	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5435643	124621364	10385152	630	7430											
CDON	50937	broad.mit.edu	37	chr11	125830980	125830980	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaatgttgatctctgtttCtgaatgggcacagctgtctc	8	15	9	9	0	3	2	0	2	3	0	5	2	3	2	0	1	2	4	0	1	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:125830980C>A	uc009zbw.2	-	20	3849	c.3721G>T	c.(3721-3723)GAA>TAA	p.E1241*	CDON_uc001qdb.3_Nonsense_Mutation_p.E595*|CDON_uc001qdc.3_Nonsense_Mutation_p.E1218*	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	1241	Cytoplasmic (Potential).				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		ATCTCTGTTTCTGAATGGGCA	0.443													18	49					2.94398e-08	3.04601e-08	1	0	A	125830980	A	A	125830980	4	1	36	1	0	0	0	0	0	1	0	0	3185	922	32	2	146	2	CDON	11	125830980	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1209616	125830980	9175536	631	7431											
GLB1L3	112937	broad.mit.edu	37	chr11	134182365	134182365	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggccgcctccgtgcccaCgctcatgacgtggcacaggt	6	6	14	15	4	1	1	1	1	0	0	2	2	2	2	4	4	1	2	4	4	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr11:134182365C>T	uc009zdf.2	+	14	1770	c.1410C>T	c.(1408-1410)CAC>CAT	p.H470H	GLB1L3_uc001qho.3_RNA	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	470					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TCCGTGCCCACGCTCATGACG	0.587													18	56					0	0	0	0	T	134182365	T	T	134182365	2	4	36	1	0	0	0	0	0	0	0	1	6467	535	19	1		1	GLB1L3	11	134182365	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	8351385	134182365	824151	632	7432											
LRTM2	654429	broad.mit.edu	37	chr12	1943843	1943843	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccctgatgggggaccccGagggcgagcacgaggaccag	9	2	17	13	3	0	1	0	1	0	0	0	6	0	3	5	4	2	1	5	4	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:1943843G>T	uc001qjt.2	+	5	1875	c.1069G>T	c.(1069-1071)GAG>TAG	p.E357*	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Nonsense_Mutation_p.E357*|LRTM2_uc010sdx.1_Nonsense_Mutation_p.E357*|LRTM2_uc001qjv.2_Nonsense_Mutation_p.E119*	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	357	Cytoplasmic (Potential).					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GGGGGACCCCGAGGGCGAGCA	0.652													31	79					3.93418e-24	4.20195e-24	1	0	T	1943843	T	T	1943843	4	4	36	1	0	0	0	0	0	1	0	0	9095	1059	37	3	1079	3	LRTM2	12	1943843	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08		1943843	131908052	633	7433											
CACNA1C	775	broad.mit.edu	37	chr12	2774834	2774834	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtccccaccacctggatGagtttaaaagaatctgggca	11	10	10	10	0	1	2	0	1	1	1	2	3	2	3	4	3	0	2	4	3	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:2774834G>C	uc009zdu.1	+	38	4943	c.4630G>C	c.(4630-4632)GAG>CAG	p.E1544Q	CACNA1C_uc009zdv.1_Missense_Mutation_p.E1493Q|CACNA1C_uc001qkb.2_Missense_Mutation_p.E1496Q|CACNA1C_uc001qkc.2_Missense_Mutation_p.E1496Q|CACNA1C_uc001qke.2_Missense_Mutation_p.E1485Q|CACNA1C_uc001qkf.2_Missense_Mutation_p.E1485Q|CACNA1C_uc001qjz.2_Missense_Mutation_p.E1496Q|CACNA1C_uc001qkd.2_Missense_Mutation_p.E1496Q|CACNA1C_uc001qkg.2_Missense_Mutation_p.E1483Q|CACNA1C_uc009zdw.1_Missense_Mutation_p.E1518Q|CACNA1C_uc001qkh.2_Missense_Mutation_p.E1485Q|CACNA1C_uc001qkl.2_Missense_Mutation_p.E1544Q|CACNA1C_uc001qkn.2_Missense_Mutation_p.E1496Q|CACNA1C_uc001qko.2_Missense_Mutation_p.E1516Q|CACNA1C_uc001qkp.2_Missense_Mutation_p.E1496Q|CACNA1C_uc001qkr.2_Missense_Mutation_p.E1513Q|CACNA1C_uc001qku.2_Missense_Mutation_p.E1496Q|CACNA1C_uc001qkq.2_Missense_Mutation_p.E1524Q|CACNA1C_uc001qks.2_Missense_Mutation_p.E1496Q|CACNA1C_uc001qkt.2_Missense_Mutation_p.E1496Q|CACNA1C_uc001qki.1_Missense_Mutation_p.E1232Q|CACNA1C_uc001qkj.1_Missense_Mutation_p.E1232Q|CACNA1C_uc001qkk.1_Missense_Mutation_p.E1232Q|CACNA1C_uc001qkm.1_Missense_Mutation_p.E1221Q|CACNA1C_uc010sea.1_Missense_Mutation_p.E187Q	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1544	Dihydropyridine binding (By similarity).|Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity	p.L1544V(1)		ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCACCTGGATGAGTTTAAAAG	0.493													29	56					0	0	0	0	C	2774834	C	C	2774834	3	2	36	1	0	0	0	0	1	0	0	0	2552	1291	45	2	4954	2	CACNA1C	12	2774834	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	830991	2774834	131077061	634	7434											
FKBP4	2288	broad.mit.edu	37	chr12	2907035	2907035	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaatgccacgcttgtatttGaggtgagtgtttggtcactg	7	14	12	8	1	1	2	1	2	0	0	1	2	1	2	2	2	1	3	2	2	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:2907035G>C	uc001qkz.2	+	3	589	c.391G>C	c.(391-393)GAG>CAG	p.E131Q		NM_002014	NP_002005	Q02790	FKBP4_HUMAN	FK506 binding protein 52	131	PPIase FKBP-type 1.				negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging				0			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	GCTTGTATTTGAGGTGAGTGT	0.552													50	156					0	0	0	0	C	2907035	C	C	2907035	3	2	36	1	0	0	0	0	1	0	0	0	5942	1291	45	2	401	2	FKBP4	12	2907035	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	132201	2907035	130944860	635	7435											
DYRK4	8798	broad.mit.edu	37	chr12	4705759	4705759	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccaatcaccttaggtttCaccagcaggccctgatggag	9	9	9	14	0	2	1	2	1	0	0	3	2	3	2	4	3	1	2	4	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:4705759C>A	uc001qmx.2	+	6	584	c.424C>A	c.(424-426)CAC>AAC	p.H142N	DYRK4_uc009zeh.1_Missense_Mutation_p.H257N|DYRK4_uc001qmy.1_Missense_Mutation_p.H142N	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	142	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			CCTTAGGTTTCACCAGCAGGC	0.527													16	34					5.35267e-07	5.51487e-07	1	0	A	4705759	A	A	4705759	3	1	36	1	0	0	0	0	1	0	0	0	4880	826	29	2	438	2	DYRK4	12	4705759	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1798724	4705759	129146136	636	7436											
AKAP3	10566	broad.mit.edu	37	chr12	4737844	4737844	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agaaacctttgtgtgggtctCctgagttggacgtttcccca	7	13	11	10	1	1	2	0	1	1	1	3	3	2	3	4	2	1	2	4	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:4737844C>G	uc001qnb.3	-	4	453	c.224G>C	c.(223-225)GGA>GCA	p.G75A		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	75					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						GTGTGGGTCTCCTGAGTTGGA	0.488													46	92					0	0	0	0	G	4737844	G	G	4737844	3	3	36	1	0	0	0	0	1	0	0	0	452	855	30	2	2345	2	AKAP3	12	4737844	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	32085	4737844	129114051	637	7437											
GNB3	2784	broad.mit.edu	37	chr12	6952355	6952355	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggctgctggtaagtgcctCgcaagatgggaagctgatcg	9	8	15	9	2	0	2	0	1	0	1	2	3	0	3	1	3	3	5	1	3	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:6952355C>A	uc001qrd.2	+	6	626	c.221C>A	c.(220-222)TCG>TAG	p.S74*	GNB3_uc001qrc.2_Nonsense_Mutation_p.S30*|GNB3_uc009zfe.2_Nonsense_Mutation_p.S74*	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	74	WD 1.				cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						GTAAGTGCCTCGCAAGATGGG	0.612													45	145					2.38262e-10	2.48198e-10	1	0	A	6952355	A	A	6952355	4	1	36	1	0	0	0	0	0	1	0	0	6556	893	31	3	235	3	GNB3	12	6952355	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2214511	6952355	126899540	638	7438											
RIMKLB	57494	broad.mit.edu	37	chr12	8906664	8906664	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttacgttgttcaacagatggGagaatgcaaagcaactgctc	13	10	10	8	1	1	2	1	0	0	2	2	3	1	2	0	1	6	5	0	1	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:8906664G>C	uc001quu.2	+	5	923	c.672G>C	c.(670-672)GGG>GGC	p.G224G	RIMKLB_uc009zgf.1_RNA|RIMKLB_uc001qux.2_Silent_p.G224G|RIMKLB_uc010sgl.1_Silent_p.G224G|RIMKLB_uc001quw.2_Silent_p.G224G	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	224	ATP-grasp.				protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CAACAGATGGGAGAATGCAAA	0.383													37	110					0	0	0	0	C	8906664	C	C	8906664	2	2	36	1	0	0	0	0	0	0	0	1	13431	1161	41	2		2	RIMKLB	12	8906664	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1954309	8906664	124945231	639	7439											
A2M	2	broad.mit.edu	37	chr12	9227270	9227270	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggctgggccgtgagataagcGaggagcacataggatgtcat	11	7	16	7	2	1	1	1	1	0	1	1	5	1	3	1	4	2	2	1	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:9227270G>C	uc001qvk.1	-	29	3755	c.3642C>G	c.(3640-3642)CTC>CTG	p.L1214L	A2M_uc001qvj.1_Silent_p.L256L|A2M_uc009zgk.1_Silent_p.L1064L	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1214					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TGAGATAAGCGAGGAGCACAT	0.587													12	38					0	0	0	0	C	9227270	C	C	9227270	2	2	36	1	0	0	0	0	0	0	0	1	4	1045	37	3		3	A2M	12	9227270	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	320606	9227270	124624625	640	7440											
A2M	2	broad.mit.edu	37	chr12	9251338	9251338	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagactttgtgatgggctGaagctcaaatccacctgtga	10	10	13	8	0	1	4	1	3	0	1	2	5	2	4	2	2	1	2	2	2	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:9251338G>C	uc001qvk.1	-	15	1829	c.1716C>G	c.(1714-1716)TTC>TTG	p.F572L	A2M_uc009zgk.1_Missense_Mutation_p.F422L	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	572					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GTGATGGGCTGAAGCTCAAAT	0.532													3	16					0	0	0	0	C	9251338	C	C	9251338	3	2	36	1	0	0	0	0	1	0	0	0	4	1281	45	2	2796	2	A2M	12	9251338	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	24068	9251338	124600557	641	7441											
KLRB1	3820	broad.mit.edu	37	chr12	9751250	9751250	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttaagagacccggtctctCtaaagtaaaaaacagaaata	18	9	7	7	1	2	2	0	0	2	2	3	3	2	2	1	1	1	2	1	1	8	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:9751250C>G	uc010sgt.1	-	4	322	c.260_splice	c.e4-1	p.E87_splice		NM_002258	NP_002249	Q12918	KLRB1_HUMAN	killer cell lectin-like receptor subfamily B,						cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0						CCCGGTCTCTCTAAAGTAAAA	0.378													50	112					0	0	0	0	G	9751250	G	G	9751250	5	3	36	1	0	0	0	0	0	0	1	0	8453	927	32	2	429	2	KLRB1	12	9751250	Splice_Site	SNP	C	TCGA-CN-4723-01A-01D-1434-08	499912	9751250	124100645	642	7442											
CLEC1A	51267	broad.mit.edu	37	chr12	10251525	10251525	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctgtacttggcctgcatctgGattcctacagcggtgagagt	7	12	12	10	1	1	1	0	1	1	1	2	3	2	2	2	3	4	2	2	3	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:10251525G>C	uc001qxb.2	-	1	81	c.-3C>G	c.(-5--1)ATCCA>ATGCA		CLEC1A_uc009zhf.2_Translation_Start_Site|CLEC1A_uc001qxc.2_Translation_Start_Site|CLEC1A_uc001qxd.2_Translation_Start_Site|CLEC1A_uc010sgx.1_Translation_Start_Site	NM_016511	NP_057595	Q8NC01	CLC1A_HUMAN	C-type lectin-like receptor-1						cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2						CCTGCATCTGGATTCCTACAG	0.552													14	14					0	0	0	0	C	10251525	C	C	10251525	1	2	36	1	0	0	0	0	0	0	0	0	3520	1189	41	2		2	CLEC1A	12	10251525	Translation_Start_Site	SNP	G	TCGA-CN-4723-01A-01D-1434-08	500275	10251525	123600370	643	7443											
STYK1	55359	broad.mit.edu	37	chr12	10783759	10783759	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctccagaacttcagagagTtgctcccgcggcacctgcag	8	8	11	14	2	1	2	1	0	0	2	3	3	3	2	3	1	4	5	3	1	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:10783759T>C	uc001qys.2	-	5	857	c.336A>G	c.(334-336)CAA>CAG	p.Q112Q		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	112						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						CTTCAGAGAGTTGCTCCCGCG	0.527										HNSCC(73;0.22)			31	96					0	0	0	0	C	10783759	C	C	10783759	2	2	36	1	0	0	0	0	0	0	0	1	15425	1722	60	5		5	STYK1	12	10783759	Silent	SNP	T	TCGA-CN-4723-01A-01D-1434-08	532234	10783759	123068136	644	7444											
TAS2R8	50836	broad.mit.edu	37	chr12	10959018	10959018	+	Missense_Mutation	SNP	G	T	T																															aaatgggacaattgcaaacaGgttaaagagagtcaagggtt																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:10959018G>T	uc010shh.1	-	1	562	c.562C>A	c.(562-564)CTG>ATG	p.L188M		NM_023918	NP_076407	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	188	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			ovary(2)	2						ATTGCAAACAGGTTAAAGAGA	0.333													22	87					1.28384e-07	1.32609e-07	1	0	T	10959018	T	T	10959018	3	4	36	1	0	0	0	0	1	0	0	0	15653	991	35	4	370	4	TAS2R8	12	10959018	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	175259	10959018	122892877	645	7445	14	2									
TAS2R8	50836	broad.mit.edu	37	chr12	10959027	10959027	+	Missense_Mutation	SNP	G	C	C																															aattgcaaacaggttaaagaGagtcaagggttcaaagtatg																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:10959027G>C	uc010shh.1	-	1	553	c.553C>G	c.(553-555)CTC>GTC	p.L185V		NM_023918	NP_076407	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	185	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			ovary(2)	2						AGGTTAAAGAGAGTCAAGGGT	0.323													19	82					0	0	0	0	C	10959027	C	C	10959027	3	2	36	1	0	0	0	0	1	0	0	0	15653	942	33	2	379	2	TAS2R8	12	10959027	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	9	10959027	122892868	646	7446	14	2									
TAS2R8	50836	broad.mit.edu	37	chr12	10959148	10959148	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actattgctgctataaggctGaccaacaaggaaatggcaaa	16	8	9	8	0	0	1	0	1	0	0	0	2	0	2	1	3	3	4	1	3	7	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:10959148G>C	uc010shh.1	-	1	432	c.432C>G	c.(430-432)GTC>GTG	p.V144V		NM_023918	NP_076407	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	144	Helical; Name=4; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			ovary(2)	2						CTATAAGGCTGACCAACAAGG	0.403													21	87					0	0	0	0	C	10959148	C	C	10959148	2	2	36	1	0	0	0	0	0	0	0	1	15653	1277	45	2		2	TAS2R8	12	10959148	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	121	10959148	122892747	647	7447											
GUCY2C	2984	broad.mit.edu	37	chr12	14769618	14769618	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaactggcactcagttctCttcaggatggctatggtgga	9	11	13	8	0	3	0	2	0	1	0	4	3	3	3	0	6	1	3	0	6	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:14769618C>G	uc001rcd.2	-	25	3056	c.2919G>C	c.(2917-2919)AAG>AAC	p.K973N		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	973	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						ACTCAGTTCTCTTCAGGATGG	0.428													67	208					0	0	0	0	G	14769618	G	G	14769618	3	3	36	1	0	0	0	0	1	0	0	0	6935	912	32	2	314	2	GUCY2C	12	14769618	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3810470	14769618	119082277	648	7448											
SLCO1B3	28234	broad.mit.edu	37	chr12	21054307	21054307	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaattctagctccaatatatTttggggctctgattgataaa	12	15	8	6	0	2	2	0	2	2	0	3	3	3	2	1	2	1	2	1	2	7	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:21054307T>G	uc001rek.2	+	14	1897	c.1771T>G	c.(1771-1773)TTT>GTT	p.F591V	SLCO1B3_uc001rel.2_Missense_Mutation_p.F591V|SLCO1B3_uc010sil.1_Missense_Mutation_p.F591V|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.F416V	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	591	Helical; Name=11; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TCCAATATATTTTGGGGCTCT	0.378													71	169					0	0	0	0	G	21054307	G	G	21054307	3	3	36	1	0	0	0	0	1	0	0	0	14788	1841	64	5	1821	5	SLCO1B3	12	21054307	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	6284689	21054307	112797588	649	7449											
CASC1	55259	broad.mit.edu	37	chr12	25267694	25267694	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtacggcatgttaatatGagcatcttgaatcaaggtaa	13	12	10	6	1	2	2	1	2	1	0	2	2	2	2	0	3	2	5	0	3	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:25267694G>C	uc001rgl.2	-	12	1571	c.1489C>G	c.(1489-1491)CAT>GAT	p.H497D	CASC1_uc001rgk.2_Missense_Mutation_p.H503D|CASC1_uc001rgm.3_Missense_Mutation_p.H561D|CASC1_uc001rgj.2_Missense_Mutation_p.H457D|CASC1_uc010sje.1_Missense_Mutation_p.H438D|CASC1_uc010sjf.1_Missense_Mutation_p.H385D|CASC1_uc010sjg.1_3'UTR	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	497										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			ATGTTAATATGAGCATCTTGA	0.378													41	112					0	0	0	0	C	25267694	C	C	25267694	3	2	36	1	0	0	0	0	1	0	0	0	2672	1290	45	2	677	2	CASC1	12	25267694	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4213387	25267694	108584201	650	7450											
DDX11	1663	broad.mit.edu	37	chr12	31237969	31237969	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agatgctagagacaggcccgGaggctgagcggctggagcag	10	4	18	9	2	0	3	0	1	0	2	0	6	0	5	1	5	3	4	1	5	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:31237969G>A	uc001rjt.1	+	5	798	c.547G>A	c.(547-549)GAG>AAG	p.E183K	DDX11_uc010sjw.1_Missense_Mutation_p.E183K|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Missense_Mutation_p.E183K|DDX11_uc001rjs.1_Missense_Mutation_p.E183K|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.E183K|DDX11_uc001rjw.1_Missense_Mutation_p.E157K|DDX11_uc001rjx.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	183	Glu-rich.|Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GACAGGCCCGGAGGCTGAGCG	0.597										Multiple Myeloma(12;0.14)			7	18					0	0	0	0	A	31237969	A	A	31237969	3	1	36	1	0	0	0	0	1	0	0	0	4360	1175	41	2	561	2	DDX11	12	31237969	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5970275	31237969	102613926	651	7451											
SYT10	341359	broad.mit.edu	37	chr12	33592455	33592455	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtcctccttgtggaaactCatcgtttggcttttctttcg	4	17	8	12	3	2	0	1	0	1	0	6	1	4	1	3	2	1	2	3	2	1	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:33592455C>T	uc001rll.1	-	1	300	c.3G>A	c.(1-3)ATG>ATA	p.M1I	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	1	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TGTGGAAACTCATCGTTTGGC	0.542													78	234					0	0	0	0	T	33592455	T	T	33592455	3	4	36	1	0	0	0	0	1	0	0	0	15532	826	29	2	1596	2	SYT10	12	33592455	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2354486	33592455	100259440	652	7452											
KIF21A	55605	broad.mit.edu	37	chr12	39713804	39713804	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttttttttctgatagagatGactgcctggaactaaagtaa	12	16	8	5	0	1	3	0	2	1	1	1	5	1	4	1	1	2	1	1	1	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:39713804G>C	uc001rly.2	-	28	3829	c.3683C>G	c.(3682-3684)TCA>TGA	p.S1228*	KIF21A_uc001rlv.2_Nonsense_Mutation_p.S233*|KIF21A_uc001rlw.2_Nonsense_Mutation_p.S545*|KIF21A_uc001rlx.2_Nonsense_Mutation_p.S1215*|KIF21A_uc001rlz.2_Nonsense_Mutation_p.S1192*|KIF21A_uc010skl.1_Nonsense_Mutation_p.S1208*|KIF21A_uc001rlu.2_5'UTR	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1228					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TGATAGAGATGACTGCCTGGA	0.328													11	53					0	0	0	0	C	39713804	C	C	39713804	4	2	36	1	0	0	0	0	0	1	0	0	8327	1294	45	2	1385	2	KIF21A	12	39713804	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	6121349	39713804	94138091	653	7453											
PDZRN4	29951	broad.mit.edu	37	chr12	41966788	41966788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagtctgacaaggacagttCtagtgcttacaacacagctg	14	9	9	9	0	2	1	0	1	2	0	2	2	2	2	0	1	4	3	0	1	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:41966788C>T	uc010skn.1	+	10	1678	c.1610C>T	c.(1609-1611)TCT>TTT	p.S537F	PDZRN4_uc001rmq.3_Missense_Mutation_p.S478F|PDZRN4_uc009zjz.2_Missense_Mutation_p.S476F|PDZRN4_uc001rmr.2_Missense_Mutation_p.S363F	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	736							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AAGGACAGTTCTAGTGCTTAC	0.473													35	115					0	0	0	0	T	41966788	T	T	41966788	3	4	36	1	0	0	0	0	1	0	0	0	11764	913	32	2	2318	2	PDZRN4	12	41966788	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2252984	41966788	91885107	654	7454											
TMEM117	84216	broad.mit.edu	37	chr12	44605135	44605135	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaaatcagcaagagctttCtggaagaaaggaaatgttag	17	8	12	4	0	2	2	1	0	1	2	2	5	2	5	0	3	2	3	0	3	7	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:44605135C>G	uc001rod.2	+	5	639	c.573C>G	c.(571-573)TTC>TTG	p.F191L	TMEM117_uc001roe.2_Missense_Mutation_p.F87L|TMEM117_uc009zkc.2_Missense_Mutation_p.F191L	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	191						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		CAAGAGCTTTCTGGAAGAAAG	0.393													3	124					0	0	0	0	G	44605135	G	G	44605135	3	3	36	1	0	0	0	0	1	0	0	0	16097	912	32	2	587	2	TMEM117	12	44605135	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2638347	44605135	89246760	655	7455											
DDN	23109	broad.mit.edu	37	chr12	49391866	49391866	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttctttgtgcgccctccgtCtgtcctggctggagtcgcag	2	13	12	14	3	2	0	0	0	2	0	5	1	4	1	3	2	1	2	3	2	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:49391866C>T	uc001rsv.1	-	2	811	c.793G>A	c.(793-795)GAC>AAC	p.D265N	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	265						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						CGCCCTCCGTCTGTCCTGGCT	0.637													32	97					0	0	0	0	T	49391866	T	T	49391866	3	4	36	1	0	0	0	0	1	0	0	0	4350	913	32	2	1346	2	DDN	12	49391866	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4786731	49391866	84460029	656	7456											
KCNH3	23416	broad.mit.edu	37	chr12	49942877	49942877	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacttcgcactcagcagcctCaccagcgtgggcttcggcaa	8	8	10	15	3	2	0	2	0	0	0	4	0	2	0	2	2	4	4	2	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:49942877C>T	uc001ruh.1	+	8	1649	c.1389C>T	c.(1387-1389)CTC>CTT	p.L463L	KCNH3_uc010smj.1_Silent_p.L403L	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	463					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						TCAGCAGCCTCACCAGCGTGG	0.682													19	43					0	0	0	0	T	49942877	T	T	49942877	2	4	36	1	0	0	0	0	0	0	0	1	8072	813	29	2		2	KCNH3	12	49942877	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	551011	49942877	83909018	657	7457											
DIP2B	57609	broad.mit.edu	37	chr12	51116990	51116990	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctttgtcttgcaggcattGagttaatcgccgccttctat	6	16	8	11	2	2	1	0	1	2	0	4	1	3	1	3	1	1	3	3	1	2	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:51116990G>C	uc001rwv.2	+	27	3328	c.3172G>C	c.(3172-3174)GAG>CAG	p.E1058Q	DIP2B_uc009zlt.2_Missense_Mutation_p.E488Q	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1058						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TGCAGGCATTGAGTTAATCGC	0.498													48	171					0	0	0	0	C	51116990	C	C	51116990	3	2	36	1	0	0	0	0	1	0	0	0	4550	1291	45	2	3278	2	DIP2B	12	51116990	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1174113	51116990	82734905	658	7458											
SLC4A8	9498	broad.mit.edu	37	chr12	51890879	51890879	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaaaaagaagaagttggatGatgccaaaaagaaggccaag	20	4	12	5	0	0	4	0	1	0	3	0	5	0	5	2	2	1	2	2	2	8	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:51890879G>A	uc001rys.1	+	22	3230	c.3052G>A	c.(3052-3054)GAT>AAT	p.D1018N	SLC4A8_uc001rym.2_Missense_Mutation_p.D965N|SLC4A8_uc001ryn.2_Missense_Mutation_p.D965N|SLC4A8_uc001ryo.2_Missense_Mutation_p.D965N|SLC4A8_uc010snj.1_Missense_Mutation_p.D1045N|SLC4A8_uc001ryr.2_Missense_Mutation_p.D1018N	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	1018	Cytoplasmic (Potential).|Potential.				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		GAAGTTGGATGATGCCAAAAA	0.453													32	118					0	0	0	0	A	51890879	A	A	51890879	3	1	36	1	0	0	0	0	1	0	0	0	14723	1290	45	2	3138	2	SLC4A8	12	51890879	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	773889	51890879	81961016	659	7459											
HOXC4	3221	broad.mit.edu	37	chr12	54448756	54448756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgacccgaaggagaaggatcGagatcgcccactcgctgtgc	10	6	13	12	4	0	3	0	1	0	2	3	7	0	4	2	2	1	1	2	2	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:54448756G>A	uc001seu.2	+	4	1242	c.562G>A	c.(562-564)GAG>AAG	p.E188K	HOXC4_uc001sex.2_Missense_Mutation_p.E188K	NM_014620	NP_055435	P09017	HXC4_HUMAN	homeobox C4	188	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GAGAAGGATCGAGATCGCCCA	0.532													19	41					0	0	0	0	A	54448756	A	A	54448756	3	1	36	1	0	0	0	0	1	0	0	0	7352	1059	37	1	568	1	HOXC4	12	54448756	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2557877	54448756	79403139	660	7460											
OR9K2	441639	broad.mit.edu	37	chr12	55524495	55524495	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaatcctttgatttactctCtgaggaacaaagatgtccaa	13	13	7	8	0	1	4	0	3	1	1	4	5	3	5	2	1	2	0	2	1	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:55524495C>G	uc010spe.1	+	1	943	c.943C>G	c.(943-945)CTG>GTG	p.L315V		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	315					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						GATTTACTCTCTGAGGAACAA	0.343													69	170					0	0	0	0	G	55524495	G	G	55524495	3	3	36	1	0	0	0	0	1	0	0	0	11308	912	32	2	945	2	OR9K2	12	55524495	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1075739	55524495	78327400	661	7461											
OR6C3	254786	broad.mit.edu	37	chr12	55726127	55726127	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggcattagtgattttatctTacatgtacattatcaggacc	11	16	7	7	0	2	1	1	1	1	0	2	2	2	2	1	2	2	2	1	2	5	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:55726127T>C	uc010spj.1	+	1	643	c.643T>C	c.(643-645)TAC>CAC	p.Y215H		NM_054104	NP_473445	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C,	215	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GATTTTATCTTACATGTACAT	0.363													76	193					0	0	0	0	C	55726127	C	C	55726127	3	2	36	1	0	0	0	0	1	0	0	0	11246	1754	61	5	645	5	OR6C3	12	55726127	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	201632	55726127	78125768	662	7462											
ERBB3	2065	broad.mit.edu	37	chr12	56495415	56495416	+	Missense_Mutation	DNP	GG	AC	AC																															ggagtatgaatacatgaaccGgaggagaaggcacagtccac																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:56495415_56495416GG>AC	uc001sjh.2	+	28	3798_3799	c.3605_3606GG>AC	c.(3604-3606)CGG>CAC	p.R1202H	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Missense_Mutation_p.R559H|ERBB3_uc010sqc.1_Missense_Mutation_p.R1143H|ERBB3_uc009zok.2_Missense_Mutation_p.R467H|ERBB3_uc001sjk.2_Missense_Mutation_p.R443H|ERBB3_uc001sjl.2_Missense_Mutation_p.R322H|PA2G4_uc001sjm.2_5'Flank|PA2G4_uc009zol.2_5'Flank|PA2G4_uc009zom.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	1202	Cytoplasmic (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TACATGAACCGGAGGAGAAGGC	0.54													38	88					0	0	0	0	AC	56495416	AC	AC	56495415	3	1	36	1	0	0	0	0	1	0	0	0	5232	1116	39	1	3846	1	ERBB3	12	56495415	Missense_Mutation	DNP	GG	TCGA-CN-4723-01A-01D-1434-08	769288	56495415	77356480	663	7463											
LRP1	4035	broad.mit.edu	37	chr12	57601825	57601825	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtggcttccattcagatttCagggctgaagatgcccagag	9	11	12	9	0	2	4	2	1	0	3	3	4	3	4	2	2	1	2	2	2	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:57601825C>T	uc001snd.2	+	77	12330	c.11864C>T	c.(11863-11865)TCA>TTA	p.S3955L		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3955	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ATTCAGATTTCAGGGCTGAAG	0.602													13	27					0	0	0	0	T	57601825	T	T	57601825	3	4	36	1	0	0	0	0	1	0	0	0	9001	838	29	2	12170	2	LRP1	12	57601825	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1106410	57601825	76250070	664	7464											
XPOT	11260	broad.mit.edu	37	chr12	64818849	64818849	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacacggtttatggaagttGaagtagcaataagattgctg	13	12	11	5	1	0	2	0	1	0	1	0	3	0	3	0	2	3	5	0	2	7	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:64818849G>T	uc001ssb.2	+	13	1765	c.1339G>T	c.(1339-1341)GAA>TAA	p.E447*		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	447	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		TATGGAAGTTGAAGTAGCAAT	0.383													61	143					2.73361e-28	2.93504e-28	1	0	T	64818849	T	T	64818849	4	4	36	1	0	0	0	0	0	1	0	0	17518	1291	45	2	1385	2	XPOT	12	64818849	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	7217024	64818849	69033046	665	7465											
ZDHHC17	23390	broad.mit.edu	37	chr12	77216299	77216299	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtccttccttagaaagctGaaagctgataaggtaaactc	13	10	8	10	1	0	3	0	2	0	1	3	3	2	3	3	1	3	3	3	1	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:77216299G>A	uc001syk.1	+	8	1048	c.885G>A	c.(883-885)CTG>CTA	p.L295L	ZDHHC17_uc001syi.1_RNA|ZDHHC17_uc001syj.2_RNA	NM_015336	NP_056151	Q8IUH5	ZDH17_HUMAN	huntingtin interacting protein 14	295	Cytoplasmic (Potential).				lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding				0						TTAGAAAGCTGAAAGCTGATA	0.254													7	21					0	0	0	0	A	77216299	A	A	77216299	2	1	36	1	0	0	0	0	0	0	0	1	17674	1277	45	2		2	ZDHHC17	12	77216299	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	12397450	77216299	56635596	666	7466											
PPP1R12A	4659	broad.mit.edu	37	chr12	80239130	80239130	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctcttccattgcctcctcctCcgcaatatctaaaggtgtat	8	14	5	14	1	2	0	0	0	2	0	6	0	6	0	5	1	1	2	5	1	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:80239130C>G	uc001syz.2	-	3	706	c.439G>C	c.(439-441)GAG>CAG	p.E147Q	PPP1R12A_uc010suc.1_Missense_Mutation_p.E60Q|PPP1R12A_uc001sza.2_Missense_Mutation_p.E147Q|PPP1R12A_uc010sud.1_Missense_Mutation_p.E147Q|PPP1R12A_uc001szb.2_Missense_Mutation_p.E147Q|PPP1R12A_uc001szc.2_Missense_Mutation_p.E147Q	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	147	ANK 4.					contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						GCCTCCTCCTCCGCAATATCT	0.373													13	35					0	0	0	0	G	80239130	G	G	80239130	3	3	36	1	0	0	0	0	1	0	0	0	12414	864	30	2	2745	2	PPP1R12A	12	80239130	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3022831	80239130	53612765	667	7467											
LRRIQ1	84125	broad.mit.edu	37	chr12	85450043	85450043	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgaaaacctagcaaaaaaacGatgttcagaagaattggtca	19	8	8	6	1	2	3	2	1	0	2	2	4	2	3	1	1	3	2	1	1	8	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:85450043G>C	uc001tac.2	+	8	1583	c.1472G>C	c.(1471-1473)CGA>CCA	p.R491P	LRRIQ1_uc001tab.1_Missense_Mutation_p.R491P|LRRIQ1_uc001taa.1_Missense_Mutation_p.R466P	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	491										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GCAAAAAAACGATGTTCAGAA	0.289													16	62					0	0	0	0	C	85450043	C	C	85450043	3	2	36	1	0	0	0	0	1	0	0	0	9079	1058	37	3	1498	3	LRRIQ1	12	85450043	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5210913	85450043	48401852	668	7468											
USP44	84101	broad.mit.edu	37	chr12	95927813	95927813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaacaaaaaacgtacatctCattcacctccaatgcaacag	17	8	4	12	1	2	0	2	0	1	0	4	0	3	0	2	0	5	3	2	0	7	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:95927813C>T	uc001teg.2	-	2	364	c.220G>A	c.(220-222)GAG>AAG	p.E74K	USP44_uc001teh.2_Missense_Mutation_p.E74K|USP44_uc009zte.2_Missense_Mutation_p.E71K	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	74	UBP-type.				anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						ACGTACATCTCATTCACCTCC	0.408											OREG0022039	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	82					0	0	0	0	T	95927813	T	T	95927813	3	4	36	1	0	0	0	0	1	0	0	0	17143	835	29	2	1938	2	USP44	12	95927813	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	10477770	95927813	37924082	669	7469											
AMDHD1	144193	broad.mit.edu	37	chr12	96348697	96348697	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tattgattataggtttggtgGatgcacacacacatccagta	12	13	9	7	0	0	1	0	1	0	0	1	2	1	2	1	3	1	3	1	3	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:96348697G>A	uc001tel.1	+	3	359	c.253G>A	c.(253-255)GAT>AAT	p.D85N	AMDHD1_uc009zth.1_Intron	NM_152435	NP_689648	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	85					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)	1						AGGTTTGGTGGATGCACACAC	0.393													28	78					0	0	0	0	A	96348697	A	A	96348697	3	1	36	1	0	0	0	0	1	0	0	0	567	1174	41	2	263	2	AMDHD1	12	96348697	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	420884	96348697	37503198	670	7470											
APAF1	317	broad.mit.edu	37	chr12	99077046	99077046	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actgggtcaagtgactgcttCctcaaagtaagtgtggatat	11	12	11	7	0	2	1	2	1	0	0	3	2	3	2	1	2	1	2	1	2	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:99077046C>A	uc001tfz.2	+	15	2749	c.2172C>A	c.(2170-2172)TTC>TTA	p.F724L	APAF1_uc001tfy.2_Missense_Mutation_p.F713L|APAF1_uc001tga.2_Missense_Mutation_p.F713L|APAF1_uc001tgb.2_Missense_Mutation_p.F724L|APAF1_uc001tgc.2_Intron|APAF1_uc009zto.2_Missense_Mutation_p.F133L	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	724	WD 3.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	GTGACTGCTTCCTCAAAGTAA	0.363													64	184					1.35869e-18	1.4411e-18	1	0	A	99077046	A	A	99077046	3	1	36	1	0	0	0	0	1	0	0	0	755	854	30	2	2226	2	APAF1	12	99077046	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2728349	99077046	34774849	671	7471											
SCYL2	55681	broad.mit.edu	37	chr12	100660970	100660970	+	5'Flank	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttttagtctttttccccctCccttactcttcgtccccggt	2	18	4	17	2	2	0	0	0	2	0	6	0	5	0	5	1	1	0	5	1	2	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:100660970C>A	uc001thn.2	+						SCYL2_uc009ztw.1_5'UTR|SCYL2_uc001thm.1_5'UTR|DEPDC4_uc001thh.1_5'Flank|DEPDC4_uc001thi.2_5'Flank|DEPDC4_uc001thj.1_5'Flank|DEPDC4_uc009ztv.1_5'Flank|DEPDC4_uc001thk.1_5'Flank|DEPDC4_uc001thl.1_5'Flank	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein						endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						TTTTCcccctcccttactctt	0.468													3	11					0.004672	0.00473388	1	0	A	100660970	A	A	100660970	1	1	36	0	1	0	0	0	0	0	0	0	14013	870	30	2		2	SCYL2	12	100660970	5'Flank	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1583924	100660970	33190925	672	7472											
UTP20	27340	broad.mit.edu	37	chr12	101767494	101767494	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttggtaaaatcagcctcgaGaaaaaagattggctgtttga	14	11	10	6	1	1	3	1	1	0	2	2	4	1	3	1	2	1	3	1	2	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:101767494G>C	uc001tia.1	+	54	7236	c.7080G>C	c.(7078-7080)GAG>GAC	p.E2360D		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2360					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TCAGCCTCGAGAAAAAAGATT	0.423													39	75					0	0	0	0	C	101767494	C	C	101767494	3	2	36	1	0	0	0	0	1	0	0	0	17167	933	33	2	7294	2	UTP20	12	101767494	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1106524	101767494	32084401	673	7473											
MYBPC1	4604	broad.mit.edu	37	chr12	102036216	102036216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggaggtgaagcagcaggagGaagaaccccaggtggacgta	13	3	18	7	1	0	2	0	1	0	1	0	6	0	6	2	6	3	3	2	6	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:102036216G>A	uc001tii.2	+	9	712	c.610G>A	c.(610-612)GAA>AAA	p.E204K	MYBPC1_uc001tif.1_Missense_Mutation_p.E217K|MYBPC1_uc001tig.2_Missense_Mutation_p.E229K|MYBPC1_uc010svq.1_Missense_Mutation_p.E191K|MYBPC1_uc001tih.2_Missense_Mutation_p.E229K|MYBPC1_uc001tij.2_Missense_Mutation_p.E204K|MYBPC1_uc010svr.1_Missense_Mutation_p.E204K|MYBPC1_uc010svs.1_Missense_Mutation_p.E204K|MYBPC1_uc010svt.1_Missense_Mutation_p.E192K|MYBPC1_uc010svu.1_Missense_Mutation_p.E185K|MYBPC1_uc001tik.2_Missense_Mutation_p.E178K	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	204					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GCAGCAGGAGGAAGAACCCCA	0.532													9	29					0	0	0	0	A	102036216	A	A	102036216	3	1	36	1	0	0	0	0	1	0	0	0	10064	1175	41	2	727	2	MYBPC1	12	102036216	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	268722	102036216	31815679	674	7474											
CCDC53	51019	broad.mit.edu	37	chr12	102439861	102439861	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaaatattgagagttgtttCaatttgttggatacgaagtg	13	16	10	2	1	1	1	1	1	0	1	1	4	1	2	0	1	1	3	0	1	6	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:102439861C>G	uc010svw.1	-	3	346	c.187G>C	c.(187-189)GAA>CAA	p.E63Q	CCDC53_uc010svx.1_RNA|CCDC53_uc010svy.1_RNA|CCDC53_uc010svz.1_Missense_Mutation_p.E63Q	NM_016053	NP_057137	Q9Y3C0	CCD53_HUMAN	coiled-coil domain containing 53	63	Potential.					WASH complex	protein binding				0						AGAGTTGTTTCAATTTGTTGG	0.284													3	13					0	0	0	0	G	102439861	G	G	102439861	3	3	36	1	0	0	0	0	1	0	0	0	2836	835	29	2	348	2	CCDC53	12	102439861	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	403645	102439861	31412034	675	7475											
C12orf48	55010	broad.mit.edu	37	chr12	102572517	102572517	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaggaaaacacaatccatCatcatggaacgtctattctt	15	11	6	9	1	4	1	2	1	2	0	5	3	5	3	1	2	2	0	1	2	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:102572517C>T	uc001tjf.2	+	8	1265	c.1153C>T	c.(1153-1155)CAT>TAT	p.H385Y	C12orf48_uc001tjg.2_Missense_Mutation_p.H304Y|C12orf48_uc010swa.1_Missense_Mutation_p.H462Y|C12orf48_uc001tjh.2_Missense_Mutation_p.H304Y|C12orf48_uc010swb.1_Intron|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_Missense_Mutation_p.H100Y|C12orf48_uc001tjk.2_Intron|C12orf48_uc009zud.2_Intron	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	385					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						CACAATCCATCATCATGGAAC	0.303													21	58					0	0	0	0	T	102572517	T	T	102572517	3	4	36	1	0	0	0	0	1	0	0	0	1698	826	29	2	932	2	C12orf48	12	102572517	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	132656	102572517	31279378	676	7476											
ALDH1L2	160428	broad.mit.edu	37	chr12	105420410	105420410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgttaataaaaacagttcCtgcttccagtttttcactca	11	16	5	9	0	2	0	2	0	0	0	4	0	4	0	2	0	2	4	2	0	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:105420410C>T	uc001tlc.2	-	22	2756	c.2629G>A	c.(2629-2631)GGA>AGA	p.G877R	ALDH1L2_uc009zuo.2_Missense_Mutation_p.G332R|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	877	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						AAAACAGTTCCTGCTTCCAGT	0.413													6	288					0	0	0	0	T	105420410	T	T	105420410	3	4	36	1	0	0	0	0	1	0	0	0	495	690	24	4	150	4	ALDH1L2	12	105420410	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2847893	105420410	28431485	677	7477											
PRDM4	11108	broad.mit.edu	37	chr12	108134781	108134781	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcactaaaagccttgctacaGaaatcacacttgtggggctt	12	11	8	10	0	2	1	2	0	0	1	2	1	2	1	1	2	3	2	1	2	4	5	rs145990889		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:108134781G>A	uc001tmp.2	-	10	2303	c.1866C>T	c.(1864-1866)TTC>TTT	p.F622F	PRDM4_uc010sww.1_Silent_p.F29F|PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	622	C2H2-type 2.				cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						CCTTGCTACAGAAATCACACT	0.458													79	187					0	0	0	0	A	108134781	A	A	108134781	2	1	36	1	0	0	0	0	0	0	0	1	12521	933	33	2		2	PRDM4	12	108134781	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2714371	108134781	25717114	678	7478											
TCTN1	79600	broad.mit.edu	37	chr12	111082789	111082789	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagactgactggagctctccCgtgtcagctcgtagcacaga	10	8	11	12	2	2	3	1	1	1	2	4	4	2	4	1	1	3	4	1	1	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:111082789C>T	uc009zvs.2	+	12	1457	c.1349C>T	c.(1348-1350)CCG>CTG	p.P450L	TCTN1_uc001trp.3_Missense_Mutation_p.P436L|TCTN1_uc001trn.3_Missense_Mutation_p.P450L|TCTN1_uc001trk.3_RNA|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	450					multicellular organismal development	extracellular region					0						GGAGCTCTCCCGTGTCAGCTC	0.517													46	147					0	0	0	0	T	111082789	T	T	111082789	3	4	36	1	0	0	0	0	1	0	0	0	15788	652	23	1	1567	1	TCTN1	12	111082789	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2948008	111082789	22769106	679	7479											
HVCN1	84329	broad.mit.edu	37	chr12	111099112	111099112	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggtgtgggtggtggctgctCctcctcctcctcctcctctt	0	15	11	15	0	1	0	0	0	1	0	7	0	7	0	6	4	1	2	6	4	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:111099112C>T	uc001trs.1	-	4	328	c.163G>A	c.(163-165)GAG>AAG	p.E55K	HVCN1_uc001trq.1_Missense_Mutation_p.E55K|HVCN1_uc001trt.1_Missense_Mutation_p.E55K|HVCN1_uc010syd.1_Missense_Mutation_p.E35K	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	55	Cytoplasmic (Potential).|Poly-Glu.				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						GGTGGCTGctcctcctcctcc	0.517													19	50					0	0	0	0	T	111099112	T	T	111099112	3	4	36	1	0	0	0	0	1	0	0	0	7501	864	30	2	678	2	HVCN1	12	111099112	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	16323	111099112	22752783	680	7480											
SH2B3	10019	broad.mit.edu	37	chr12	111885521	111885521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagcacctccactttccctCggtcgtggacatgctccacc	6	9	8	18	2	0	0	0	0	0	0	5	1	3	1	5	2	2	3	5	2	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:111885521C>T	uc001tse.2	+	7	1655	c.1298C>T	c.(1297-1299)TCG>TTG	p.S433L	SH2B3_uc010syf.1_Missense_Mutation_p.S433L|SH2B3_uc001tsf.2_Missense_Mutation_p.S434L|SH2B3_uc010syg.1_Missense_Mutation_p.S231L	NM_005475	NP_005466	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	433	SH2.				blood coagulation	cytosol	signal transducer activity			ovary(1)	1						CACTTTCCCTCGGTCGTGGAC	0.667													31	71					0	0	0	0	T	111885521	T	T	111885521	3	4	36	1	0	0	0	0	1	0	0	0	14294	893	31	1	1320	1	SH2B3	12	111885521	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	786409	111885521	21966374	681	7481											
ACAD10	80724	broad.mit.edu	37	chr12	112140045	112140045	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgaaaatgggccctggatGagatttatgagagcagaaat	14	9	14	4	0	0	4	0	3	0	3	0	7	0	5	1	3	1	1	1	3	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:112140045G>A	uc001tsq.2	+	3	467	c.267G>A	c.(265-267)ATG>ATA	p.M89I	ACAD10_uc009zvw.2_Missense_Mutation_p.M89I|ACAD10_uc001tso.3_Missense_Mutation_p.M89I|ACAD10_uc001tsp.2_Missense_Mutation_p.M89I|ACAD10_uc009zvx.2_Missense_Mutation_p.M89I	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	89							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						GGCCCTGGATGAGATTTATGA	0.403													70	162					0	0	0	0	A	112140045	A	A	112140045	3	1	36	1	0	0	0	0	1	0	0	0	108	1290	45	2	273	2	ACAD10	12	112140045	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	254524	112140045	21711850	682	7482											
C12orf51	283450	broad.mit.edu	37	chr12	112711540	112711540	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcccagggttacaccactGatcgatatagtcatttgagc	11	12	8	10	1	1	2	1	2	0	0	3	3	2	2	2	1	2	1	2	1	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:112711540G>A	uc009zwc.2	-	4	583	c.565C>T	c.(565-567)CAG>TAG	p.Q189*	C12orf51_uc010syk.1_Nonsense_Mutation_p.Q12*|C12orf51_uc001tts.2_Nonsense_Mutation_p.Q12*|C12orf51_uc001ttt.3_Nonsense_Mutation_p.Q12*	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TTACACCACTGATCGATATAG	0.473													51	136					0	0	0	0	A	112711540	A	A	112711540	4	1	36	1	0	0	0	0	0	1	0	0	1702	1299	45	2	11689	2	C12orf51	12	112711540	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	571495	112711540	21140355	683	7483											
TBX5	6910	broad.mit.edu	37	chr12	114837439	114837439	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtaactgggaaacatccgccTaagagagagggacggaggga	14	4	16	7	2	0	2	0	0	0	2	1	7	1	6	2	4	2	1	2	4	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:114837439T>G	uc001tvo.2	-	4	738	c.243_splice	c.e4-1	p.R81_splice	TBX5_uc001tvp.2_Splice_Site_p.R81_splice|TBX5_uc001tvq.2_Splice_Site_p.R31_splice|TBX5_uc010syv.1_Splice_Site_p.R81_splice	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1						cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		AACATCCGCCTAAGAGAGAGG	0.478													45	125					0	0	0	0	G	114837439	G	G	114837439	5	3	36	1	0	0	0	0	0	0	1	0	15727	1536	53	5	1406	5	TBX5	12	114837439	Splice_Site	SNP	T	TCGA-CN-4723-01A-01D-1434-08	2125899	114837439	19014456	684	7484											
WSB2	55884	broad.mit.edu	37	chr12	118473077	118473077	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaagcacacagatctcaGtgagctaatgtggacgtcac	14	7	11	9	1	2	3	2	1	1	2	3	5	2	4	0	1	2	2	0	1	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:118473077G>T	uc001twr.2	-	7	984	c.886C>A	c.(886-888)CTG>ATG	p.L296M	WSB2_uc010sza.1_Missense_Mutation_p.L71M|WSB2_uc010szb.1_Missense_Mutation_p.L86M|WSB2_uc009zws.1_Missense_Mutation_p.L296M	NM_018639	NP_061109	Q9NYS7	WSB2_HUMAN	WD SOCS-box protein 2	296	WD 5.				intracellular signal transduction					ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACAGATCTCAGTGAGCTAATG	0.537											OREG0022175	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	68					9.65021e-13	1.01129e-12	1	0	T	118473077	T	T	118473077	3	4	36	1	0	0	0	0	1	0	0	0	17473	1020	36	4	340	4	WSB2	12	118473077	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3635638	118473077	15378818	685	7485											
PRKAB1	5564	broad.mit.edu	37	chr12	120111803	120111803	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tagccatcctggatctgccgGaaggagagcatcagtacaag	12	7	12	10	1	2	1	1	0	1	1	3	4	3	3	3	3	4	2	3	3	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:120111803G>C	uc009zwu.2	+	4	461	c.358G>C	c.(358-360)GAA>CAA	p.E120Q	PRKAB1_uc001txg.2_Missense_Mutation_p.E120Q	NM_006253	NP_006244	Q9Y478	AAKB1_HUMAN	AMP-activated protein kinase beta 1	120					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol					0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	GGATCTGCCGGAAGGAGAGCA	0.567													27	139					0	0	0	0	C	120111803	C	C	120111803	3	2	36	1	0	0	0	0	1	0	0	0	12557	1175	41	2	368	2	PRKAB1	12	120111803	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1638726	120111803	13740092	686	7486											
OASL	8638	broad.mit.edu	37	chr12	121469368	121469368	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaggaccaccgcaggccttGatcaggctcacatagacctc	10	6	9	16	1	2	2	2	1	0	1	3	3	2	3	5	3	0	2	5	3	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:121469368G>C	uc001tzj.1	-	3	540	c.534C>G	c.(532-534)ATC>ATG	p.I178M	OASL_uc001tzk.1_Missense_Mutation_p.I178M	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	178					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CGCAGGCCTTGATCAGGCTCA	0.557													45	86					0	0	0	0	C	121469368	C	C	121469368	3	2	36	1	0	0	0	0	1	0	0	0	10856	1280	45	2	1026	2	OASL	12	121469368	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1357565	121469368	12382527	687	7487											
DNAH10	196385	broad.mit.edu	37	chr12	124325980	124325980	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggagtttcggaagatcttgCgggctgaagggcgcgtggag	7	9	19	6	4	1	2	0	1	1	1	2	5	1	5	0	5	1	2	0	5	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:124325980C>T	uc001uft.3	+	29	4919	c.4894C>T	c.(4894-4896)CGG>TGG	p.R1632W		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1632	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GAAGATCTTGCGGGCTGAAGG	0.453													5	247					0	0	0	0	T	124325980	T	T	124325980	3	4	36	1	0	0	0	0	1	0	0	0	4620	759	27	1	5008	1	DNAH10	12	124325980	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2856612	124325980	9525915	688	7488											
DHX37	57647	broad.mit.edu	37	chr12	125449160	125449160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caaccgagtcccctccggtgGaggcttaaagacctaggatt	10	8	11	12	2	0	1	0	0	0	1	2	4	2	3	5	4	1	1	5	4	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:125449160G>A	uc001ugy.2	-	15	1924	c.1825C>T	c.(1825-1827)CCA>TCA	p.P609S		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	609	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CCCTCCGGTGGAGGCTTAAAG	0.547													19	61					0	0	0	0	A	125449160	A	A	125449160	3	1	36	1	0	0	0	0	1	0	0	0	4532	1174	41	2	1700	2	DHX37	12	125449160	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1123180	125449160	8402735	689	7489											
TMEM132B	114795	broad.mit.edu	37	chr12	126136994	126136994	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgacttttcaggtcctctCgccgttgtctgactccatcc	4	14	8	15	2	3	2	1	2	2	0	7	2	6	2	4	1	0	2	4	1	0	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr12:126136994C>T	uc001uhe.1	+	8	1915	c.1907C>T	c.(1906-1908)TCG>TTG	p.S636L	TMEM132B_uc001uhf.1_Missense_Mutation_p.S148L	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	636	Extracellular (Potential).					integral to membrane		p.S636L(1)		skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CAGGTCCTCTCGCCGTTGTCT	0.567													16	32					0	0	0	0	T	126136994	T	T	126136994	3	4	36	1	0	0	0	0	1	0	0	0	16112	893	31	1	1937	1	TMEM132B	12	126136994	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	687834	126136994	7714901	690	7490											
LATS2	26524	broad.mit.edu	37	chr13	21565498	21565498	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatgtactccagggcggcctCgatgctcctgctgccagtct	5	10	12	14	2	1	0	0	0	1	0	4	2	3	0	4	2	4	3	4	2	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:21565498C>T	uc009zzs.2	-	3	753	c.388G>A	c.(388-390)GAG>AAG	p.E130K	LATS2_uc001unr.3_Missense_Mutation_p.E130K	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	130	UBA.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		AGGGCGGCCTCGATGCTCCTG	0.577													15	65					0	0	0	0	T	21565498	T	T	21565498	3	4	36	1	0	0	0	0	1	0	0	0	8687	893	31	1	2902	1	LATS2	13	21565498	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08		21565498	93604380	691	7491											
SKA3	221150	broad.mit.edu	37	chr13	21729931	21729931	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctattggagtagctaggtttGagttgtattttgataaaagc	11	16	11	3	0	0	2	0	2	0	0	0	3	0	3	0	2	2	5	0	2	6	10			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:21729931G>C	uc001unt.2	-	8	1233	c.1139C>G	c.(1138-1140)TCA>TGA	p.S380*	SKA3_uc001unv.2_Nonsense_Mutation_p.S298*|SKA3_uc001unu.2_Intron	NM_145061	NP_659498	Q8IX90	SKA3_HUMAN	SKA3	380					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding				0						AGCTAGGTTTGAGTTGTATTT	0.333													29	118					0	0	0	0	C	21729931	C	C	21729931	4	2	36	1	0	0	0	0	0	1	0	0	14419	1294	45	2	154	2	SKA3	13	21729931	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	164433	21729931	93439947	692	7492											
RNF17	56163	broad.mit.edu	37	chr13	25374667	25374667	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaagacattgttccacagAattcagtaagtgagacttta	15	12	8	6	0	1	4	1	2	0	3	2	5	2	4	1	0	0	2	1	0	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:25374667A>C	uc001upr.2	+	13	1794	c.1753A>C	c.(1753-1755)AAT>CAT	p.N585H	RNF17_uc010tdd.1_Missense_Mutation_p.N444H|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.N585H|RNF17_uc001ups.2_Missense_Mutation_p.N524H	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	585					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TGTTCCACAGAATTCAGTAAG	0.373													4	84					0	0	0	0	C	25374667	C	C	25374667	3	2	36	1	0	0	0	0	1	0	0	0	13526	246	9	5	1803	5	RNF17	13	25374667	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	3644736	25374667	89795211	693	7493											
RNF17	56163	broad.mit.edu	37	chr13	25448363	25448363	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatttgttgattatggatCaactgcaaagctgacattaa	15	13	7	6	0	1	2	1	2	0	0	1	3	1	3	0	1	3	3	0	1	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:25448363C>A	uc001upr.2	+	33	4600	c.4559C>A	c.(4558-4560)TCA>TAA	p.S1520*	RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Nonsense_Mutation_p.S1516*|RNF17_uc001ups.2_Nonsense_Mutation_p.S1459*|RNF17_uc010aac.2_Nonsense_Mutation_p.S712*|RNF17_uc010aad.2_Nonsense_Mutation_p.S530*	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1520	Tudor 4.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GATTATGGATCAACTGCAAAG	0.294													18	86					3.52763e-06	3.62842e-06	1	0	A	25448363	A	A	25448363	4	1	36	1	0	0	0	0	0	1	0	0	13526	838	29	2	4689	2	RNF17	13	25448363	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	73696	25448363	89721515	694	7494											
RNF6	6049	broad.mit.edu	37	chr13	26793630	26793630	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	attatggtctctcataagccGataatcttcatcattgagtt	11	16	6	8	1	5	1	3	1	2	0	6	2	5	1	1	1	1	1	1	1	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:26793630G>C	uc001uqo.2	-	3	448	c.157C>G	c.(157-159)CGG>GGG	p.R53G	RNF6_uc001uqn.1_Missense_Mutation_p.R53G|RNF6_uc010aak.2_Missense_Mutation_p.R53G|RNF6_uc001uqp.2_Missense_Mutation_p.R53G|RNF6_uc001uqq.2_Missense_Mutation_p.R53G|RNF6_uc010tdk.1_Translation_Start_Site	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	53					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		CTCATAAGCCGATAATCTTCA	0.383													4	141					0	0	0	0	C	26793630	C	C	26793630	3	2	36	1	0	0	0	0	1	0	0	0	13563	1057	37	3	1912	3	RNF6	13	26793630	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1345267	26793630	88376248	695	7495											
SLC46A3	283537	broad.mit.edu	37	chr13	29286950	29286950	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catattcctaggaaactagtCaaaaaagaggcactacccaa	18	7	6	10	0	1	1	1	0	0	1	2	2	2	2	2	2	2	1	2	2	9	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:29286950C>G	uc001usi.2	-	2	1897	c.927G>C	c.(925-927)TTG>TTC	p.L309F	SLC46A3_uc001usg.2_Missense_Mutation_p.L234F|SLC46A3_uc001usj.2_Missense_Mutation_p.L309F|SLC46A3_uc001ush.2_Missense_Mutation_p.L309F|SLC46A3_uc001usk.2_Missense_Mutation_p.L234F	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	309	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)		GGAAACTAGTCAAAAAAGAGG	0.383													30	81					0	0	0	0	G	29286950	G	G	29286950	3	3	36	1	0	0	0	0	1	0	0	0	14710	825	29	2	488	2	SLC46A3	13	29286950	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2493320	29286950	85882928	696	7496											
SLC46A3	283537	broad.mit.edu	37	chr13	29287679	29287679	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaaaacgtgacacttttttCtgaacttcctgcaaagaaat	14	14	5	8	1	1	3	0	2	1	1	2	3	2	3	1	0	3	1	1	0	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:29287679C>G	uc001usi.2	-	2	1168	c.198G>C	c.(196-198)CAG>CAC	p.Q66H	SLC46A3_uc001usg.2_5'UTR|SLC46A3_uc001usj.2_Missense_Mutation_p.Q66H|SLC46A3_uc001ush.2_Missense_Mutation_p.Q66H|SLC46A3_uc001usk.2_5'UTR	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	66	Extracellular (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)		ACACTTTTTTCTGAACTTCCT	0.353													14	35					0	0	0	0	G	29287679	G	G	29287679	3	3	36	1	0	0	0	0	1	0	0	0	14710	912	32	2	1217	2	SLC46A3	13	29287679	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	729	29287679	85882199	697	7497											
KATNAL1	84056	broad.mit.edu	37	chr13	30854258	30854258	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctctaaatggttcatcttGacaggacacagggaaatctg	13	11	9	8	0	4	1	1	1	3	0	5	3	4	3	0	3	0	1	0	3	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:30854258G>C	uc001uss.2	-	3	366	c.265C>G	c.(265-267)CAA>GAA	p.Q89E	KATNAL1_uc001ust.2_Missense_Mutation_p.Q89E	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	89						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		GGTTCATCTTGACAGGACACA	0.393													18	51					0	0	0	0	C	30854258	C	C	30854258	3	2	36	1	0	0	0	0	1	0	0	0	8024	1299	45	2	1243	2	KATNAL1	13	30854258	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1566579	30854258	84315620	698	7498											
FRY	10129	broad.mit.edu	37	chr13	32776558	32776558	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagaccgggaagtattctCtatggaacacacggcccgct	12	7	10	12	3	1	1	0	0	1	1	2	3	1	3	2	3	1	2	2	3	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:32776558C>G	uc001utx.2	+	31	4408	c.3912C>G	c.(3910-3912)CTC>CTG	p.L1304L	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GAAGTATTCTCTATGGAACAC	0.478													10	126					0	0	0	0	G	32776558	G	G	32776558	2	3	36	1	0	0	0	0	0	0	0	1	6097	900	32	2		2	FRY	13	32776558	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1922300	32776558	82393320	699	7499											
RFC3	5983	broad.mit.edu	37	chr13	34395395	34395395	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaattgagaattgaacatCagaccatcacagtaagcatt	19	9	6	7	0	2	3	2	2	0	2	2	4	2	3	1	0	2	2	1	0	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:34395395C>G	uc001uuz.2	+	2	324	c.214C>G	c.(214-216)CAG>GAG	p.Q72E	RFC3_uc001uva.2_Missense_Mutation_p.Q72E|RFC3_uc010ted.1_Missense_Mutation_p.Q72E	NM_002915	NP_002906	P40938	RFC3_HUMAN	replication factor C 3 isoform 1	72					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding				0		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		AATTGAACATCAGACCATCAC	0.418													4	127					0	0	0	0	G	34395395	G	G	34395395	3	3	36	1	0	0	0	0	1	0	0	0	13311	827	29	2	220	2	RFC3	13	34395395	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1618837	34395395	80774483	700	7500											
POSTN	10631	broad.mit.edu	37	chr13	38153456	38153456	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaatgaaaactcctggtgtCaggtgataaagaatgatgtt	14	11	10	6	0	1	4	1	3	0	1	2	4	2	4	2	2	1	1	2	2	6	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:38153456C>T	uc001uwo.3	-	13	1819	c.1701G>A	c.(1699-1701)CTG>CTA	p.L567L	POSTN_uc010tet.1_Silent_p.L95L|POSTN_uc001uwp.3_Silent_p.L567L|POSTN_uc001uwr.2_Silent_p.L567L|POSTN_uc001uwq.2_Silent_p.L567L|POSTN_uc010teu.1_Silent_p.L567L|POSTN_uc010tev.1_Silent_p.L567L|POSTN_uc010tew.1_Silent_p.L567L|POSTN_uc010tex.1_Silent_p.L482L	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	567	FAS1 4.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CTCCTGGTGTCAGGTGATAAA	0.323													8	127					0	0	0	0	T	38153456	T	T	38153456	2	4	36	1	0	0	0	0	0	0	0	1	12314	813	29	2		2	POSTN	13	38153456	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3758061	38153456	77016422	701	7501											
LHFP	10186	broad.mit.edu	37	chr13	40174981	40174981	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacttacccccaagaaactGaattcctccagccactcttc	11	10	3	17	0	2	2	1	1	1	1	5	2	4	2	5	0	3	0	5	0	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:40174981G>C	uc001uxf.2	-	2	884	c.373C>G	c.(373-375)CAG>GAG	p.Q125E		NM_005780	NP_005771	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner precursor	125	Helical; (Potential).					integral to membrane	DNA binding		HMGA2/LHFP(2)	soft_tissue(2)|lung(1)|breast(1)	4		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		CCAAGAAACTGAATTCCTCCA	0.483			T	HMGA2	lipoma								30	76					0	0	0	0	C	40174981	C	C	40174981	3	2	36	1	0	0	0	0	1	0	0	0	8804	1299	45	2	241	2	LHFP	13	40174981	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2021525	40174981	74994897	702	7502											
KIAA0564	23078	broad.mit.edu	37	chr13	42393495	42393495	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgccaaggcaatgattctGaaggagggatggataggaaa	14	8	14	5	0	2	2	0	2	2	0	2	6	2	6	1	5	1	1	1	5	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:42393495G>A	uc001uyj.2	-	15	1798	c.1728C>T	c.(1726-1728)TTC>TTT	p.F576F	KIAA0564_uc001uyk.2_Silent_p.F576F	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	576						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		CAATGATTCTGAAGGAGGGAT	0.368													22	66					0	0	0	0	A	42393495	A	A	42393495	2	1	36	1	0	0	0	0	0	0	0	1	8224	1281	45	2		2	KIAA0564	13	42393495	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2218514	42393495	72776383	703	7503											
AKAP11	11215	broad.mit.edu	37	chr13	42872840	42872840	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccactgatgaagatgatgatGatactaaccagtctgtgtca	13	11	9	8	0	2	6	1	5	1	1	2	6	2	6	2	0	2	0	2	0	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:42872840G>A	uc001uys.1	+	7	698	c.523G>A	c.(523-525)GAT>AAT	p.D175N		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	175					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		AGATGATGATGATACTAACCA	0.403													37	106					0	0	0	0	A	42872840	A	A	42872840	3	1	36	1	0	0	0	0	1	0	0	0	447	1290	45	2	541	2	AKAP11	13	42872840	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	479345	42872840	72297038	704	7504											
TSC22D1	8848	broad.mit.edu	37	chr13	45008797	45008797	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgagccctgcgatgctggctGggcggggggctgtgtggtgc	2	9	21	9	2	0	1	0	1	0	0	0	2	0	1	1	6	4	3	1	6	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:45008797G>T	uc001uzn.3	-	3	3678	c.3187C>A	c.(3187-3189)CAG>AAG	p.Q1063K	TSC22D1_uc001uzo.1_Intron|TSC22D1_uc001uzm.3_Missense_Mutation_p.Q134K	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	1063					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		GATGCTGGCTGGGCGGGGGGC	0.652													6	33					0.00307968	0.00312564	1	0	T	45008797	T	T	45008797	3	4	36	1	0	0	0	0	1	0	0	0	16674	1357	47	4	38	4	TSC22D1	13	45008797	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2135957	45008797	70161081	705	7505											
TSC22D1	8848	broad.mit.edu	37	chr13	45008999	45008999	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttctctgaccgcatacatCaaatggcttttcactagatc	10	14	5	12	1	4	2	2	1	2	1	6	2	4	2	1	1	1	2	1	1	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:45008999C>T	uc001uzn.3	-	3	3476	c.2985G>A	c.(2983-2985)TTG>TTA	p.L995L	TSC22D1_uc001uzo.1_Intron|TSC22D1_uc001uzm.3_Silent_p.L66L	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	995					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		CCGCATACATCAAATGGCTTT	0.378													57	191					0	0	0	0	T	45008999	T	T	45008999	2	4	36	1	0	0	0	0	0	0	0	1	16674	825	29	2		2	TSC22D1	13	45008999	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	202	45008999	70160879	706	7506											
TSC22D1	8848	broad.mit.edu	37	chr13	45149590	45149590	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcccattgatcacaacattCtgttgtggaaggtgaggcaa	11	12	10	8	0	2	2	1	2	1	0	3	3	3	3	1	3	1	2	1	3	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:45149590C>G	uc001uzn.3	-	1	1112	c.621G>C	c.(619-621)CAG>CAC	p.Q207H	TSC22D1_uc001uzo.1_Missense_Mutation_p.Q207H	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	207	His-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TCACAACATTCTGTTGTGGAA	0.353													10	33					0	0	0	0	G	45149590	G	G	45149590	3	3	36	1	0	0	0	0	1	0	0	0	16674	912	32	2	2741	2	TSC22D1	13	45149590	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	140591	45149590	70020288	707	7507											
HTR2A	3356	broad.mit.edu	37	chr13	47409577	47409577	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttggcccgtgtgccaagatCacttacacacaaagtagctt	11	11	8	11	1	1	1	1	0	0	1	1	1	1	1	2	1	3	2	2	1	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:47409577C>G	uc001vbq.2	-	3	945	c.811G>C	c.(811-813)GAT>CAT	p.D271H	HTR2A_uc001vbr.2_Missense_Mutation_p.D171H|HTR2A_uc010acr.2_Missense_Mutation_p.D271H	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	271	Cytoplasmic (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GTGCCAAGATCACTTACACAC	0.453													26	66					0	0	0	0	G	47409577	G	G	47409577	3	3	36	1	0	0	0	0	1	0	0	0	7480	826	29	2	608	2	HTR2A	13	47409577	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2259987	47409577	67760301	708	7508											
C13orf1	57213	broad.mit.edu	37	chr13	50489231	50489231	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgttcaaataatattttttCaaaaccaggtggaggcgtat	13	14	8	6	1	2	0	2	0	0	0	2	1	2	1	1	3	1	2	1	3	6	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:50489231C>G	uc001vdl.2	-	5	821	c.559G>C	c.(559-561)GAA>CAA	p.E187Q	C13orf1_uc001vdm.2_Missense_Mutation_p.E148Q|C13orf1_uc010tgm.1_RNA	NM_020456	NP_065189	Q5W111	SPRY7_HUMAN	chromosome 13 open reading frame 1 isoform 1	187											0		Lung NSC(96;7.5e-06)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Acute lymphoblastic leukemia(7;0.117)		GBM - Glioblastoma multiforme(99;1.72e-10)|COAD - Colon adenocarcinoma(199;0.208)		AATATTTTTTCAAAACCAGGT	0.279													14	79					0	0	0	0	G	50489231	G	G	50489231	3	3	36	1	0	0	0	0	1	0	0	0	1723	835	29	2	35	2	C13orf1	13	50489231	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3079654	50489231	64680647	709	7509											
DHRS12	79758	broad.mit.edu	37	chr13	52348132	52348132	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactggagatcattggtgttCagtttctgaaccaacattcc	10	13	9	9	0	3	2	2	1	1	1	4	4	4	2	2	2	2	2	2	2	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:52348132C>T	uc001vfq.2	-	7	597	c.549G>A	c.(547-549)CTG>CTA	p.L183L	DHRS12_uc001vfr.1_Silent_p.L134L|DHRS12_uc001vfs.1_Silent_p.L134L			A0PJE2	DHR12_HUMAN	RecName: Full=Dehydrogenase/reductase SDR family member 12;          EC=1.1.-.-;	183							binding|oxidoreductase activity				0		Breast(56;0.00173)|Prostate(109;0.00899)|Lung NSC(96;0.0199)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.81e-08)		CATTGGTGTTCAGTTTCTGAA	0.443													33	100					0	0	0	0	T	52348132	T	T	52348132	2	4	36	1	0	0	0	0	0	0	0	1	4510	813	29	2		2	DHRS12	13	52348132	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1858901	52348132	62821746	710	7510											
RNF219	79596	broad.mit.edu	37	chr13	79190259	79190259	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttgctgttgtctgactctGacatcattgaatccaactca	9	15	6	11	0	5	3	2	3	3	0	6	3	6	3	1	0	2	2	1	0	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:79190259G>A	uc001vkw.1	-	6	1696	c.1637C>T	c.(1636-1638)TCA>TTA	p.S546L	uc001vku.1_RNA|RNF219_uc010afb.1_Missense_Mutation_p.S356L|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	546	Ser-rich.						zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		GTCTGACTCTGACATCATTGA	0.413													50	210					0	0	0	0	A	79190259	A	A	79190259	3	1	36	1	0	0	0	0	1	0	0	0	13547	1294	45	2	547	2	RNF219	13	79190259	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	26842127	79190259	35979619	711	7511											
SLITRK5	26050	broad.mit.edu	37	chr13	88329668	88329668	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcctcctgctggttttcatCatgtccgtcttcgtggccgc	3	14	10	14	3	3	0	2	0	1	0	6	0	5	0	4	2	2	2	4	2	0	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:88329668C>G	uc001vln.2	+	2	2244	c.2025C>G	c.(2023-2025)ATC>ATG	p.I675M	SLITRK5_uc010tic.1_Missense_Mutation_p.I434M	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	675	Helical; (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TGGTTTTCATCATGTCCGTCT	0.617													14	61					0	0	0	0	G	88329668	G	G	88329668	3	3	36	1	0	0	0	0	1	0	0	0	14810	816	29	2	2027	2	SLITRK5	13	88329668	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	9139409	88329668	26840210	712	7512											
HS6ST3	266722	broad.mit.edu	37	chr13	96743704	96743704	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcaagaaggagacgtggctCttctcccgcttctccaccgg	7	8	12	14	3	3	2	0	0	3	2	5	3	3	2	3	4	0	3	3	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:96743704C>G	uc001vmw.2	+	1	612	c.588C>G	c.(586-588)CTC>CTG	p.L196L		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	196	Lumenal (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					AGACGTGGCTCTTCTCCCGCT	0.637													3	18					0	0	0	0	G	96743704	G	G	96743704	2	3	36	1	0	0	0	0	0	0	0	1	7411	900	32	2		2	HS6ST3	13	96743704	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	8414036	96743704	18426174	713	7513											
DOCK9	23348	broad.mit.edu	37	chr13	99549807	99549807	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttattgctgtcttgcctgtaGatggcagaaaatctggcatt	9	15	10	7	0	2	2	0	0	2	2	2	2	2	2	1	2	2	4	1	2	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:99549807G>C	uc001vnt.2	-	15	1702	c.1647C>G	c.(1645-1647)ATC>ATG	p.I549M	DOCK9_uc001vnw.2_Missense_Mutation_p.I548M|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.I549M|DOCK9_uc010tis.1_Missense_Mutation_p.I548M|DOCK9_uc010tit.1_Missense_Mutation_p.I549M|DOCK9_uc010afu.1_Missense_Mutation_p.I364M	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	549					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CTTGCCTGTAGATGGCAGAAA	0.388													57	275					0	0	0	0	C	99549807	C	C	99549807	3	2	36	1	0	0	0	0	1	0	0	0	4716	932	33	2	4791	2	DOCK9	13	99549807	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2806103	99549807	15620071	714	7514											
ERCC5	2073	broad.mit.edu	37	chr13	103514472	103514472	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttttgacgtgaagtcatctCcatgtgaaaaactgaagaca	14	11	8	8	1	2	5	1	4	1	1	3	5	2	5	1	0	1	0	1	0	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:103514472C>G	uc001vpw.2	+	8	1416	c.973C>G	c.(973-975)CCA>GCA	p.P325A	ERCC5_uc001vpu.1_Missense_Mutation_p.P779A|ERCC5_uc010tjb.1_Missense_Mutation_p.P325A|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.P157A	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	325					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GAAGTCATCTCCATGTGAAAA	0.453			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				4	291					0	0	0	0	G	103514472	G	G	103514472	3	3	36	1	0	0	0	0	1	0	0	0	5240	855	30	2	1003	2	ERCC5	13	103514472	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3964665	103514472	11655406	715	7515											
MYO16	23026	broad.mit.edu	37	chr13	109438029	109438029	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgaatggaaatatcccatTagattatgctgtagaaggga	14	12	11	4	0	0	3	0	1	0	2	1	5	1	5	1	2	1	2	1	2	7	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:109438029T>C	uc001vqt.1	+	5	614	c.488T>C	c.(487-489)TTA>TCA	p.L163S	MYO16_uc010agk.1_Missense_Mutation_p.L185S	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	163	ANK 4.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AATATCCCATTAGATTATGCT	0.333													13	119					0	0	0	0	C	109438029	C	C	109438029	3	2	36	1	0	0	0	0	1	0	0	0	10117	1764	61	5	502	5	MYO16	13	109438029	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	5923557	109438029	5731849	716	7516											
MYO16	23026	broad.mit.edu	37	chr13	109496836	109496836	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgagcggttccaccaaacccGagcaggtaatcatgctttca	11	9	9	12	2	2	1	2	1	0	0	3	2	3	1	3	2	4	4	3	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:109496836G>A	uc001vqt.1	+	10	1303	c.1177G>A	c.(1177-1179)GAG>AAG	p.E393K	MYO16_uc010agk.1_Missense_Mutation_p.E415K|MYO16_uc001vqu.1_Missense_Mutation_p.E193K	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	393					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CACCAAACCCGAGCAGGTAAT	0.388													18	63					0	0	0	0	A	109496836	A	A	109496836	3	1	36	1	0	0	0	0	1	0	0	0	10117	1059	37	1	1211	1	MYO16	13	109496836	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	58807	109496836	5673042	717	7517											
ARHGEF7	8874	broad.mit.edu	37	chr13	111927983	111927983	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attaaaactctgggcaacgtCacttacatgtcccaggtcct	11	11	7	12	1	2	0	1	0	1	0	4	0	4	0	2	2	3	1	2	2	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr13:111927983C>T	uc001vrs.2	+	13	1690	c.1440C>T	c.(1438-1440)GTC>GTT	p.V480V	ARHGEF7_uc001vrr.2_Silent_p.V459V|ARHGEF7_uc001vrt.2_Silent_p.V430V|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_Silent_p.V302V|ARHGEF7_uc001vrv.3_Silent_p.V302V|ARHGEF7_uc001vrw.3_Silent_p.V302V|ARHGEF7_uc001vrx.3_Silent_p.V302V|ARHGEF7_uc010tjo.1_Silent_p.V377V|ARHGEF7_uc010tjp.1_Silent_p.V224V|ARHGEF7_uc010agn.1_Silent_p.V224V	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	480	PH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			TGGGCAACGTCACTTACATGT	0.537													4	216					0	0	0	0	T	111927983	T	T	111927983	2	4	36	1	0	0	0	0	0	0	0	1	911	813	29	2		2	ARHGEF7	13	111927983	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2431147	111927983	3241895	718	7518											
OR11H4	390442	broad.mit.edu	37	chr14	20711066	20711066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattcagattttcctcttctCattgtttttggtgatttatg	6	22	7	6	0	3	2	2	1	2	1	5	3	4	2	1	1	0	1	1	1	1	9			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:20711066C>T	uc010tld.1	+	1	116	c.116C>T	c.(115-117)TCA>TTA	p.S39L		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		TTCCTCTTCTCATTGTTTTTG	0.448													29	177					0	0	0	0	T	20711066	T	T	20711066	3	4	36	1	0	0	0	0	1	0	0	0	10982	838	29	2	118	2	OR11H4	14	20711066	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08		20711066	86638474	719	7519											
CCNB1IP1	57820	broad.mit.edu	37	chr14	20781915	20781915	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catctgtttcagatggccctCagccttgctgaaattgtatt	8	15	8	10	0	3	2	2	1	1	1	3	2	3	2	2	1	2	3	2	1	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:20781915C>G	uc001vwv.2	-	6	992	c.343G>C	c.(343-345)GAG>CAG	p.E115Q	CCNB1IP1_uc001vww.2_Missense_Mutation_p.E115Q|CCNB1IP1_uc001vwx.2_Missense_Mutation_p.E115Q|CCNB1IP1_uc001vwy.2_Missense_Mutation_p.E115Q|CCNB1IP1_uc001vwz.2_Missense_Mutation_p.E115Q	NM_182851	NP_878271	Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1 isoform 3	115						chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	soft_tissue(2)|ovary(1)	3	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)		AGATGGCCCTCAGCCTTGCTG	0.373			T	HMGA2	leiomyoma								112	77					0	0	0	0	G	20781915	G	G	20781915	3	3	36	1	0	0	0	0	1	0	0	0	2927	835	29	2	498	2	CCNB1IP1	14	20781915	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	70849	20781915	86567625	720	7520											
MYH7	4625	broad.mit.edu	37	chr14	23882971	23882971	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccaaaagagggacccaccttCgtgccaatgtcacggctctt	10	8	9	14	2	2	1	1	0	1	1	3	2	2	2	4	2	1	1	4	2	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:23882971C>G	uc001wjx.2	-	39	5893	c.5787G>C	c.(5785-5787)ACG>ACC	p.T1929T		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1929	Potential.		T -> M (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GACCCACCTTCGTGCCAATGT	0.592													48	36					0	0	0	0	G	23882971	G	G	23882971	2	3	36	1	0	0	0	0	0	0	0	1	10092	871	31	3		3	MYH7	14	23882971	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3101056	23882971	83466569	721	7521											
PSME2	5721	broad.mit.edu	37	chr14	24614473	24614473	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctttcttctcctgcttatCtgtttccatctaaggcaaaa	8	18	4	11	0	5	0	0	0	5	0	7	0	6	0	2	1	1	3	2	1	4	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:24614473C>G	uc001wmj.2	-	5	306	c.241G>C	c.(241-243)GAT>CAT	p.D81H	PSME2_uc001wmk.2_Missense_Mutation_p.D4H|RNF31_uc001wml.1_5'Flank|RNF31_uc001wmm.1_5'Flank|RNF31_uc001wmn.1_5'Flank|RNF31_uc010alg.1_5'Flank	NM_002818	NP_002809	Q9UL46	PSME2_HUMAN	proteasome activator subunit 2	81					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome activator complex					0				GBM - Glioblastoma multiforme(265;0.00839)		TCCTGCTTATCTGTTTCCATC	0.463													6	151					0	0	0	0	G	24614473	G	G	24614473	3	3	36	1	0	0	0	0	1	0	0	0	12769	913	32	2	506	2	PSME2	14	24614473	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	731502	24614473	82735067	722	7522											
AKAP6	9472	broad.mit.edu	37	chr14	33290655	33290655	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgatggacctaaatgggatGagtgaggatgccctggaatg	11	10	15	5	0	0	3	0	3	0	0	0	7	0	7	2	4	1	0	2	4	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:33290655G>A	uc001wrq.2	+	13	3806	c.3636G>A	c.(3634-3636)ATG>ATA	p.M1212I		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1212					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TAAATGGGATGAGTGAGGATG	0.393													107	88					0	0	0	0	A	33290655	A	A	33290655	3	1	36	1	0	0	0	0	1	0	0	0	455	1290	45	2	3682	2	AKAP6	14	33290655	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	8676182	33290655	74058885	723	7523											
AKAP6	9472	broad.mit.edu	37	chr14	33291388	33291388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccctgactgtttgggagaaGaattacaaggaaaacatgat	15	9	10	7	0	0	4	0	2	0	2	0	6	0	5	2	2	2	1	2	2	6	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:33291388G>A	uc001wrq.2	+	13	4539	c.4369G>A	c.(4369-4371)GAA>AAA	p.E1457K		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1457					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TTTGGGAGAAGAATTACAAGG	0.363													35	28					0	0	0	0	A	33291388	A	A	33291388	3	1	36	1	0	0	0	0	1	0	0	0	455	943	33	2	4415	2	AKAP6	14	33291388	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	733	33291388	74058152	724	7524											
SSTR1	6751	broad.mit.edu	37	chr14	38678632	38678632	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcctcctctccttcctcctCtcctagccccagcccgggca	3	9	6	23	2	2	0	0	0	2	0	7	0	5	0	9	1	2	1	9	1	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:38678632C>G	uc001wul.1	+	3	655	c.38C>G	c.(37-39)TCT>TGT	p.S13C	SSTR1_uc010amu.1_RNA	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	13	Extracellular (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	CCTTCCTCCTCTCCTAGCCCC	0.746													11	6					0	0	0	0	G	38678632	G	G	38678632	3	3	36	1	0	0	0	0	1	0	0	0	15263	913	32	2	40	2	SSTR1	14	38678632	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5387244	38678632	68670908	725	7525											
RPL10L	140801	broad.mit.edu	37	chr14	47120418	47120418	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aattcgtcagcattaaacttCgtgaagccccacttcttgga	11	12	7	11	2	2	1	1	1	1	0	4	2	2	2	2	1	3	1	2	1	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:47120418C>T	uc001wwg.2	-	1	611	c.522G>A	c.(520-522)ACG>ACA	p.T174T		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	174					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						CATTAAACTTCGTGAAGCCCC	0.507													106	77					0	0	0	0	T	47120418	T	T	47120418	2	4	36	1	0	0	0	0	0	0	0	1	13621	871	31	1		1	RPL10L	14	47120418	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	8441786	47120418	60229122	726	7526											
FRMD6	122786	broad.mit.edu	37	chr14	52182162	52182162	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgagcaacagccaccgcctCtatatgaatctgcagcctgt	10	9	8	14	1	2	2	0	2	2	0	2	2	2	2	4	0	5	2	4	0	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:52182162C>G	uc001wzd.2	+	10	1254	c.969C>G	c.(967-969)CTC>CTG	p.L323L	FRMD6_uc001wzb.2_Silent_p.L315L|FRMD6_uc001wzc.2_Silent_p.L315L|FRMD6_uc001wze.2_Silent_p.L246L|FRMD6_uc001wzf.2_Silent_p.L16L|FRMD6_uc001wzg.2_5'Flank	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	323	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					GCCACCGCCTCTATATGAATC	0.557													52	29					0	0	0	0	G	52182162	G	G	52182162	2	3	36	1	0	0	0	0	0	0	0	1	6088	900	32	2		2	FRMD6	14	52182162	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5061744	52182162	55167378	727	7527											
DDHD1	80821	broad.mit.edu	37	chr14	53513591	53513591	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgaccaataggcagtatgCgacgtgacagctgaccaata	14	7	11	9	2	0	3	0	3	0	0	0	5	0	3	2	1	2	3	2	1	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:53513591C>T	uc001xai.2	-	13	2828	c.2598G>A	c.(2596-2598)TCG>TCA	p.S866S	DDHD1_uc001xaj.2_Silent_p.S845S|DDHD1_uc001xah.2_Silent_p.S838S|DDHD1_uc001xag.2_Silent_p.S420S	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	866	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					AGGCAGTATGCGACGTGACAG	0.408													4	116					0	0	0	0	T	53513591	T	T	53513591	2	4	36	1	0	0	0	0	0	0	0	1	4343	755	27	1		1	DDHD1	14	53513591	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1331429	53513591	53835949	728	7528											
C14orf101	54916	broad.mit.edu	37	chr14	57052606	57052606	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttggagcagtagctgcatCattactttttttcaccgttt	8	18	7	8	1	2	0	2	0	0	0	2	1	2	1	1	1	4	5	1	1	2	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:57052606C>G	uc001xcm.2	+	3	442	c.320C>G	c.(319-321)TCA>TGA	p.S107*	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xck.2_Nonsense_Mutation_p.S107*|C14orf101_uc010aot.1_Nonsense_Mutation_p.S107*|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_Translation_Start_Site	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	107	Helical; (Potential).					integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		GTAGCTGCATCATTACTTTTT	0.378													141	129					0	0	0	0	G	57052606	G	G	57052606	4	3	36	1	0	0	0	0	0	1	0	0	1740	838	29	2	330	2	C14orf101	14	57052606	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3539015	57052606	50296934	729	7529											
DHRS7	51635	broad.mit.edu	37	chr14	60619717	60619717	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggtacagatatgatacccagGatgctattcacagtaacaat	15	10	8	8	0	1	2	1	1	0	1	1	3	1	3	1	2	4	3	1	2	6	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:60619717G>A	uc001xes.2	-	4	757	c.573C>T	c.(571-573)ATC>ATT	p.I191I	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Silent_p.I141I|DHRS7_uc001xeu.2_Silent_p.I191I	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	191							binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		TGATACCCAGGATGCTATTCA	0.433													109	94					0	0	0	0	A	60619717	A	A	60619717	2	1	36	1	0	0	0	0	0	0	0	1	4517	1164	41	2		2	DHRS7	14	60619717	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3567111	60619717	46729823	730	7530											
SYNE2	23224	broad.mit.edu	37	chr14	64669652	64669652	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgatgtctgcgatgatcaaGagatccagaagaggctcgct	12	9	12	8	2	2	5	1	2	1	3	4	7	3	5	1	1	1	2	1	1	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:64669652G>C	uc001xgm.2	+	100	18402	c.18172G>C	c.(18172-18174)GAG>CAG	p.E6058Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E6058Q|SYNE2_uc010apy.2_Missense_Mutation_p.E2443Q|SYNE2_uc001xgn.2_Missense_Mutation_p.E1020Q|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.E28Q|SYNE2_uc001xgq.2_Missense_Mutation_p.E423Q	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6058	Cytoplasmic (Potential).|Spectrin 6.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CGATGATCAAGAGATCCAGAA	0.512													53	43					0	0	0	0	C	64669652	C	C	64669652	3	2	36	1	0	0	0	0	1	0	0	0	15512	943	33	2	18566	2	SYNE2	14	64669652	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4049935	64669652	42679888	731	7531											
MPP5	64398	broad.mit.edu	37	chr14	67784156	67784156	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgcaaagaagaataaaaaGaagaggaaaaaggttttata	22	8	10	1	0	0	4	0	0	0	4	0	5	0	5	0	2	1	2	0	2	11	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:67784156G>C	uc001xjc.2	+	11	1795	c.1329G>C	c.(1327-1329)AAG>AAC	p.K443N	MPP5_uc001xjd.2_Missense_Mutation_p.K409N|ATP6V1D_uc001xje.2_Intron	NM_022474	NP_071919	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5	443					tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			ovary(1)	1				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		AGAATAAAAAGAAGAGGAAAA	0.338													42	34					0	0	0	0	C	67784156	C	C	67784156	3	2	36	1	0	0	0	0	1	0	0	0	9790	933	33	2	1363	2	MPP5	14	67784156	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3114504	67784156	39565384	732	7532											
PLEKHH1	57475	broad.mit.edu	37	chr14	68043190	68043190	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctatgagcagctcattGgaaaactgatggatggtgaa	12	10	12	7	0	1	3	1	3	0	0	1	5	1	5	1	3	4	2	1	3	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:68043190G>T	uc001xjl.1	+	17	2573	c.2431G>T	c.(2431-2433)GGA>TGA	p.G811*	PLEKHH1_uc010tsw.1_Nonsense_Mutation_p.G379*|PLEKHH1_uc001xjn.1_Nonsense_Mutation_p.G326*|PLEKHH1_uc010tsx.1_5'Flank	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	811						cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		GCAGCTCATTGGAAAACTGAT	0.562													49	39					3.7052e-28	3.97125e-28	1	0	T	68043190	T	T	68043190	4	4	36	1	0	0	0	0	0	1	0	0	12131	1349	47	4	2493	4	PLEKHH1	14	68043190	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	259034	68043190	39306350	733	7533											
PCNX	22990	broad.mit.edu	37	chr14	71428976	71428976	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggattgaaatgtctgagttCatccgagaggccacaccccc	10	8	11	12	1	2	3	1	2	1	1	3	5	3	4	4	2	0	1	4	2	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:71428976C>A	uc001xmo.2	+	3	842	c.396C>A	c.(394-396)TTC>TTA	p.F132L	PCNX_uc001xmn.3_Missense_Mutation_p.F132L|PCNX_uc010are.1_Missense_Mutation_p.F132L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	132						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGTCTGAGTTCATCCGAGAGG	0.443													6	469					0.00307968	0.00312564	1	0	A	71428976	A	A	71428976	3	1	36	1	0	0	0	0	1	0	0	0	11645	825	29	2	406	2	PCNX	14	71428976	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3385786	71428976	35920564	734	7534											
DNAL1	83544	broad.mit.edu	37	chr14	74125577	74125577	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactggccagaggccatctGaagccaaagagataaaactt	17	6	9	9	0	1	3	0	1	1	2	1	4	1	3	3	2	3	0	3	2	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:74125577G>T	uc001xoq.3	+	3	235	c.70G>T	c.(70-72)GAA>TAA	p.E24*	DNAL1_uc010aru.2_5'UTR|DNAL1_uc010arv.2_Intron	NM_031427	NP_113615	Q4LDG9	DNAL1_HUMAN	axonemal dynein light chain 1	24											0				BRCA - Breast invasive adenocarcinoma(234;0.00384)|KIRC - Kidney renal clear cell carcinoma(182;0.095)		GAGGCCATCTGAAGCCAAAGA	0.403													269	171					3.09578e-119	3.36821e-119	1	0	T	74125577	T	T	74125577	4	4	36	1	0	0	0	0	0	1	0	0	4679	1291	45	2	80	2	DNAL1	14	74125577	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2696601	74125577	33223963	735	7535											
ANGEL1	23357	broad.mit.edu	37	chr14	77269772	77269772	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctactggtcgctgacaagcGatgctgcagaagcggaaacg	11	6	13	11	4	0	2	0	1	0	1	1	4	0	3	1	2	6	3	1	2	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:77269772G>A	uc001xsv.2	-	7	1673	c.1560C>T	c.(1558-1560)ATC>ATT	p.I520I	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	520										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		GCTGACAAGCGATGCTGCAGA	0.473													83	61					0	0	0	0	A	77269772	A	A	77269772	2	1	36	1	0	0	0	0	0	0	0	1	608	1048	37	1		1	ANGEL1	14	77269772	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3144195	77269772	30079768	736	7536											
SNW1	22938	broad.mit.edu	37	chr14	78184606	78184606	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgtctacggtctgaaccaGaaaactccttgtcgggaaca	11	10	9	11	2	3	2	0	1	3	1	5	3	4	3	2	2	4	0	2	2	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:78184606G>C	uc001xuf.2	-	14	1463	c.1436C>G	c.(1435-1437)TCT>TGT	p.S479C	SNW1_uc010tvm.1_Missense_Mutation_p.S404C|SNW1_uc010asu.2_Missense_Mutation_p.S317C|SNW1_uc010tvn.1_Missense_Mutation_p.L506V	NM_012245	NP_036377	Q13573	SNW1_HUMAN	SKI-interacting protein	479					negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		GTCTGAACCAGAAAACTCCTT	0.428													9	445					0	0	0	0	C	78184606	C	C	78184606	3	2	36	1	0	0	0	0	1	0	0	0	14943	942	33	2	178	2	SNW1	14	78184606	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	914834	78184606	29164934	737	7537											
ADCK1	57143	broad.mit.edu	37	chr14	78374175	78374175	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atccactgggacctgtccacGgagcgggtcctcctgatgga	7	8	13	13	2	0	1	0	1	0	0	4	4	4	4	5	4	1	0	5	4	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:78374175G>A	uc001xui.2	+	7	870	c.771G>A	c.(769-771)ACG>ACA	p.T257T	ADCK1_uc010tvo.1_RNA|ADCK1_uc001xuj.2_Silent_p.T189T|ADCK1_uc001xuk.1_Silent_p.T131T	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	264	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		ACCTGTCCACGGAGCGGGTCC	0.567													31	26					0	0	0	0	A	78374175	A	A	78374175	2	1	36	1	0	0	0	0	0	0	0	1	288	1103	39	1		1	ADCK1	14	78374175	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	189569	78374175	28975365	738	7538											
NRXN3	9369	broad.mit.edu	37	chr14	79181351	79181351	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgctgcgggtgtcaagtcctCctgttcacggatgagtgcca	6	11	13	11	2	2	1	2	1	0	0	4	2	4	2	3	2	3	2	3	2	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:79181351C>G	uc001xun.2	+	5	1285	c.794C>G	c.(793-795)TCC>TGC	p.S265C	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.S399C	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	638	Extracellular (Potential).|Laminin G-like 3.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GTCAAGTCCTCCTGTTCACGG	0.562													3	118					0	0	0	0	G	79181351	G	G	79181351	3	3	36	1	0	0	0	0	1	0	0	0	10721	855	30	2	804	2	NRXN3	14	79181351	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	807176	79181351	28168189	739	7539											
TTC7B	145567	broad.mit.edu	37	chr14	91123528	91123528	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccctactcacccagtgcaggGagcccatgcagagcttggca	9	6	11	15	0	1	1	1	0	0	1	1	2	1	2	3	2	5	4	3	2	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:91123528G>A	uc001xyp.2	-	11	1453	c.1331C>T	c.(1330-1332)TCC>TTC	p.S444F	TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	444							binding			ovary(2)	2		Melanoma(154;0.222)				CCAGTGCAGGGAGCCCATGCA	0.622													97	65					0	0	0	0	A	91123528	A	A	91123528	3	1	36	1	0	0	0	0	1	0	0	0	16781	1174	41	2	1240	2	TTC7B	14	91123528	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	11942177	91123528	16226012	740	7540											
KIAA1409	57578	broad.mit.edu	37	chr14	94084637	94084637	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatagctgcaagccccatGccacggcaggacctttgtac	10	8	9	14	1	1	0	1	0	0	0	1	1	1	1	4	2	5	4	4	2	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:94084637G>A	uc001ybv.1	+	27	3942	c.3859G>A	c.(3859-3861)GCC>ACC	p.A1287T	KIAA1409_uc001ybs.1_Missense_Mutation_p.A1265T	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1442						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CAAGCCCCATGCCACGGCAGG	0.423													71	46					0	0	0	0	A	94084637	A	A	94084637	3	1	36	1	0	0	0	0	1	0	0	0	8269	1319	46	4	3895	4	KIAA1409	14	94084637	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2961109	94084637	13264903	741	7541											
DDX24	57062	broad.mit.edu	37	chr14	94526564	94526564	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagagaggcgtttgatgcagGagatactgttggcaaacact	12	9	13	7	1	0	3	0	1	0	2	0	5	0	3	0	3	3	4	0	3	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:94526564G>A	uc001ycj.2	-	5	1892	c.1793C>T	c.(1792-1794)TCC>TTC	p.S598F	DDX24_uc010twq.1_Missense_Mutation_p.S555F|DDX24_uc010twr.1_Missense_Mutation_p.S348F	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	598	Helicase C-terminal.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		TTTGATGCAGGAGATACTGTT	0.498													67	42					0	0	0	0	A	94526564	A	A	94526564	3	1	36	1	0	0	0	0	1	0	0	0	4368	1174	41	2	806	2	DDX24	14	94526564	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	441927	94526564	12822976	742	7542											
GSC	145258	broad.mit.edu	37	chr14	95235376	95235376	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggtacttggtctcctggaaGaggttctcgagagcttcgag	7	11	15	8	2	2	2	0	0	2	2	5	5	2	3	1	4	2	3	1	4	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:95235376G>A	uc001ydu.2	-	2	681	c.534C>T	c.(532-534)CTC>CTT	p.L178L		NM_173849	NP_776248	P56915	GSC_HUMAN	goosecoid	178	Homeobox.				gastrulation|middle ear morphogenesis		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(154;0.0896)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.202)|Epithelial(152;0.239)		TCTCCTGGAAGAGGTTCTCGA	0.667													7	8					0	0	0	0	A	95235376	A	A	95235376	2	1	36	1	0	0	0	0	0	0	0	1	6853	929	33	2		2	GSC	14	95235376	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	708812	95235376	12114164	743	7543											
GLRX5	51218	broad.mit.edu	37	chr14	96000110	96000110	+	5'Flank	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtaggaagtcaataaccaagCtagtaaataactgtatattg	17	11	8	5	0	1	0	1	0	0	0	1	1	1	1	1	1	3	4	1	1	11	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:96000110C>G	uc001yem.1	+						SNHG10_uc001yek.2_RNA|SNHG10_uc001yel.2_RNA	NM_016417	NP_057501	Q86SX6	GLRX5_HUMAN	glutaredoxin 5						cell redox homeostasis|hemopoiesis	mitochondrion	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(154;0.135)		Epithelial(152;0.133)|COAD - Colon adenocarcinoma(157;0.21)|all cancers(159;0.212)		AATAACCAAGCTAGTAAATAA	0.333													16	13					0	0	0	0	G	96000110	G	G	96000110	1	3	36	0	1	0	0	0	0	0	0	0	6499	812	28	4		4	GLRX5	14	96000110	5'Flank	SNP	C	TCGA-CN-4723-01A-01D-1434-08	764734	96000110	11349430	744	7544											
C14orf129	51527	broad.mit.edu	37	chr14	96848583	96848583	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttttttttttttttacaGaatggaaacagactgtaatc	11	19	6	5	0	0	2	0	0	0	2	1	3	0	3	0	1	3	2	0	1	4	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:96848583G>A	uc001yfj.3	+	3	145	c.0_splice	c.e3-1		C14orf129_uc001yfl.2_Splice_Site	NM_016472	NP_057556	Q9P0R6	GSKIP_HUMAN	chromosome 14 open reading frame 129							cytoplasm	protein binding				0		Melanoma(154;0.226)		Epithelial(152;0.109)|COAD - Colon adenocarcinoma(157;0.205)		TTTTTTTACAGAATGGAAACA	0.333													34	31					0	0	0	0	A	96848583	A	A	96848583	5	1	36	1	0	0	0	0	0	0	1	0	1750	956	33	2	1	2	C14orf129	14	96848583	Splice_Site	SNP	G	TCGA-CN-4723-01A-01D-1434-08	848473	96848583	10500957	745	7545											
BEGAIN	57596	broad.mit.edu	37	chr14	101004323	101004323	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctcagttgagcaaggttcCgtagagctgggccttggtga	7	10	15	9	2	1	3	1	2	0	1	2	3	2	3	2	3	2	6	2	3	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:101004323C>T	uc010txa.1	-	6	1911	c.1765G>A	c.(1765-1767)GGA>AGA	p.G589R	BEGAIN_uc001yhp.2_Missense_Mutation_p.G525R|BEGAIN_uc001yhq.2_Missense_Mutation_p.G589R	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	589						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)				AGCAAGGTTCCGTAGAGCTGG	0.706													13	22					0	0	0	0	T	101004323	T	T	101004323	3	4	36	1	0	0	0	0	1	0	0	0	1399	661	23	1	20	1	BEGAIN	14	101004323	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4155740	101004323	6345217	746	7546											
KLC1	3831	broad.mit.edu	37	chr14	104129088	104129088	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgcccagcagggcggctaCgagatccccgcgcggctgcg	5	4	16	16	6	0	1	0	0	0	1	1	2	1	1	3	3	4	4	3	3	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr14:104129088C>T	uc001yno.2	+	5	929	c.621C>T	c.(619-621)TAC>TAT	p.Y207Y	KLC1_uc010tyd.1_Silent_p.Y366Y|KLC1_uc010tye.1_Silent_p.Y203Y|KLC1_uc001ynm.1_Silent_p.Y207Y|KLC1_uc001ynn.1_Silent_p.Y203Y|KLC1_uc010tyf.1_Silent_p.Y207Y	NM_182923	NP_891553	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 2	207					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				AGGGCGGCTACGAGATCCCCG	0.622													4	123					0	0	0	0	T	104129088	T	T	104129088	2	4	36	1	0	0	0	0	0	0	0	1	8372	547	19	1		1	KLC1	14	104129088	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3124765	104129088	3220452	747	7547											
CYFIP1	23191	broad.mit.edu	37	chr15	22993080	22993080	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgtggagtacgcagagctGaagacggtgtgcttccagaa	11	8	14	8	3	0	4	0	1	0	3	2	5	1	5	1	2	3	4	1	2	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:22993080G>A	uc001yus.2	+	26	3071	c.2967G>A	c.(2965-2967)CTG>CTA	p.L989L	CYFIP1_uc001yut.2_Silent_p.L989L|CYFIP1_uc010aya.1_Silent_p.L1017L|CYFIP1_uc001yuu.2_Silent_p.L558L|CYFIP1_uc001yuv.2_Silent_p.L183L	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	989					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		ACGCAGAGCTGAAGACGGTGT	0.612													50	126					0	0	0	0	A	22993080	A	A	22993080	2	1	36	1	0	0	0	0	0	0	0	1	4154	1277	45	2		2	CYFIP1	15	22993080	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08		22993080	79538312	748	7548											
C15orf2	23742	broad.mit.edu	37	chr15	24924415	24924415	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atggacagagagaaaattctAcacttcaagcacccactact	16	8	6	11	0	2	2	1	0	1	2	2	4	2	3	1	1	3	1	1	1	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:24924415A>G	uc001ywo.2	+	1	3875	c.3401A>G	c.(3400-3402)TAC>TGC	p.Y1134C		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	1134					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AGAAAATTCTACACTTCAAGC	0.483													46	138					0	0	0	0	G	24924415	G	G	24924415	3	3	36	1	0	0	0	0	1	0	0	0	1790	391	14	5	3403	5	C15orf2	15	24924415	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	1931335	24924415	77606977	749	7549											
SNRPN	6638	broad.mit.edu	37	chr15	25223557	25223557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctatttcctttccaggtcCacctcccccaggaatgcgtc	6	13	6	16	1	1	0	0	0	1	0	6	1	5	1	6	2	1	0	6	2	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:25223557C>T	uc001ywp.1	+	13	1579	c.689C>T	c.(688-690)CCA>CTA	p.P230L	SNRPN_uc001ywq.1_Missense_Mutation_p.P230L|SNRPN_uc001ywr.1_Missense_Mutation_p.P230L|SNRPN_uc001yws.1_Missense_Mutation_p.P230L|SNRPN_uc001ywt.1_Missense_Mutation_p.P230L|SNRPN_uc001ywv.1_Missense_Mutation_p.P233L|SNRPN_uc001yww.1_Missense_Mutation_p.P230L|SNRPN_uc001ywx.1_Missense_Mutation_p.P230L|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	230	Repeat-rich region.|				RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		TTTCCAGGTCCACCTCCCCCA	0.473									Prader-Willi_syndrome				85	285					0	0	0	0	T	25223557	T	T	25223557	3	4	36	1	0	0	0	0	1	0	0	0	14934	594	21	4	715	4	SNRPN	15	25223557	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	299142	25223557	77307835	750	7550											
CHRM5	1133	broad.mit.edu	37	chr15	34356124	34356124	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctgtcacaaggtgaaaatCatgccctgccccttcccagt	9	9	9	14	0	2	1	2	1	0	0	3	1	3	1	4	2	2	1	4	2	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:34356124C>G	uc001zhk.1	+	3	1876	c.1206C>G	c.(1204-1206)ATC>ATG	p.I402M	CHRM5_uc001zhl.1_Missense_Mutation_p.I402M	NM_012125	NP_036257	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	402	Cytoplasmic (By similarity).				cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	AGGTGAAAATCATGCCCTGCC	0.502													3	135					0	0	0	0	G	34356124	G	G	34356124	3	3	36	1	0	0	0	0	1	0	0	0	3395	816	29	2	1208	2	CHRM5	15	34356124	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	9132567	34356124	68175268	751	7551											
ZFP106	64397	broad.mit.edu	37	chr15	42742378	42742378	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcatcaacctgtgcatcttCtagagaggttttcaagtcta	10	14	8	9	0	6	1	3	0	3	1	6	2	6	1	1	1	2	2	1	1	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:42742378C>T	uc001zpw.2	-	2	2358	c.2023G>A	c.(2023-2025)GAA>AAA	p.E675K	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Missense_Mutation_p.E458K|ZFP106_uc001zpy.1_Missense_Mutation_p.E698K	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	675						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		TGTGCATCTTCTAGAGAGGTT	0.413													6	273					0	0	0	0	T	42742378	T	T	42742378	3	4	36	1	0	0	0	0	1	0	0	0	17704	922	32	2	3700	2	ZFP106	15	42742378	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	8386254	42742378	59789014	752	7552											
TP53BP1	7158	broad.mit.edu	37	chr15	43699588	43699588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaccaagtatctttagtgaGaaacataatcgtgtttatat	15	14	7	5	1	1	2	0	1	1	2	2	3	1	2	1	0	1	2	1	0	7	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:43699588G>A	uc001zrs.2	-	28	6060	c.5912C>T	c.(5911-5913)TCT>TTT	p.S1971F	TP53BP1_uc010udp.1_Missense_Mutation_p.S1969F|TP53BP1_uc001zrq.3_Missense_Mutation_p.S1974F|TP53BP1_uc001zrr.3_Missense_Mutation_p.S1976F|TP53BP1_uc001zrp.2_Missense_Mutation_p.S388F	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1971					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TCTTTAGTGAGAAACATAATC	0.413								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					39	100					0	0	0	0	A	43699588	A	A	43699588	3	1	36	1	0	0	0	0	1	0	0	0	16450	942	33	2	10	2	TP53BP1	15	43699588	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	957210	43699588	58831804	753	7553											
MAP1A	4130	broad.mit.edu	37	chr15	43815427	43815427	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgttccagggctgggacaaGaagaacatgtgatgaaggag	13	7	15	6	0	0	4	0	2	0	2	1	6	1	6	1	3	1	2	1	3	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:43815427G>A	uc001zrt.2	+	4	2223	c.1756G>A	c.(1756-1758)GAA>AAA	p.E586K		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	586						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GCTGGGACAAGAAGAACATGT	0.542													16	33					0	0	0	0	A	43815427	A	A	43815427	3	1	36	1	0	0	0	0	1	0	0	0	9280	943	33	2	1758	2	MAP1A	15	43815427	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	115839	43815427	58715965	754	7554											
PDIA3	2923	broad.mit.edu	37	chr15	44058971	44058971	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggatgctgggcacaaactCaactttgctgtagctagccg	9	10	11	11	1	1	0	1	0	0	0	1	1	1	1	1	2	6	5	1	2	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:44058971C>G	uc001zsu.2	+	8	1039	c.891C>G	c.(889-891)CTC>CTG	p.L297L	PDIA3_uc010bdp.2_Silent_p.L277L|PDIA3_uc010ued.1_Silent_p.L71L	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	297					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		GGCACAAACTCAACTTTGCTG	0.458													19	47					0	0	0	0	G	44058971	G	G	44058971	2	3	36	1	0	0	0	0	0	0	0	1	11723	813	29	2		2	PDIA3	15	44058971	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	243544	44058971	58472421	755	7555											
SPG11	80208	broad.mit.edu	37	chr15	44878014	44878014	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggatgtatccttcaaaatCtggcaaaggatgcaaagctt	14	11	9	7	0	2	0	1	0	1	0	3	2	3	2	1	3	2	4	1	3	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:44878014C>G	uc001ztx.2	-	29	4972	c.4941G>C	c.(4939-4941)CAG>CAC	p.Q1647H	SPG11_uc010bdw.2_5'Flank|SPG11_uc010ueh.1_Missense_Mutation_p.Q1647H|SPG11_uc010uei.1_Missense_Mutation_p.Q1647H|SPG11_uc001zty.1_Missense_Mutation_p.Q376H	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1647	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CCTTCAAAATCTGGCAAAGGA	0.358													38	157					0	0	0	0	G	44878014	G	G	44878014	3	3	36	1	0	0	0	0	1	0	0	0	15107	912	32	2	2438	2	SPG11	15	44878014	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	819043	44878014	57653378	756	7556											
DUOX1	53905	broad.mit.edu	37	chr15	45426095	45426095	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catttcgtgggaggtgcagcGatttgatgggtggtacaaca	9	11	15	6	2	0	1	0	1	0	0	1	3	0	2	0	4	4	2	0	4	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:45426095G>A	uc001zus.1	+	4	438	c.92G>A	c.(91-93)CGA>CAA	p.R31Q	DUOX1_uc001zut.1_Missense_Mutation_p.R31Q|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	31	Peroxidase-like; mediates peroxidase activity.|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		GAGGTGCAGCGATTTGATGGG	0.592													38	115					0	0	0	0	A	45426095	A	A	45426095	3	1	36	1	0	0	0	0	1	0	0	0	4822	1058	37	1	98	1	DUOX1	15	45426095	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	548081	45426095	57105297	757	7557											
ONECUT1	3175	broad.mit.edu	37	chr15	53081966	53081966	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggtggctgccgcggtgcGccacggagctgcgcgcgtgg	3	5	20	13	7	0	0	0	0	0	0	0	1	0	1	2	5	4	3	2	5	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:53081966G>C	uc002aci.1	-	1	244	c.116C>G	c.(115-117)GCG>GGG	p.A39G		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	39					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		GCCGCGGTGCGCCACGGAGCT	0.756													4	4					0	0	0	0	C	53081966	C	C	53081966	3	2	36	1	0	0	0	0	1	0	0	0	10922	1087	38	3	1289	3	ONECUT1	15	53081966	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	7655871	53081966	49449426	758	7558											
CCPG1	9236	broad.mit.edu	37	chr15	55653003	55653003	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtttaactcttcctgtaatGaggataaggctttttcttcc	8	18	7	8	0	2	1	0	1	2	0	4	2	4	2	2	2	1	3	2	2	3	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:55653003G>A	uc002acv.1	-	8	1133	c.968C>T	c.(967-969)TCA>TTA	p.S323L	CCPG1_uc002acy.2_Missense_Mutation_p.S323L|CCPG1_uc002acu.1_Missense_Mutation_p.S179L|CCPG1_uc002acw.1_Missense_Mutation_p.S48L|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Missense_Mutation_p.S323L|CCPG1_uc002acz.1_Missense_Mutation_p.S323L	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	323	Potential.|Lumenal (Potential).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		TTCCTGTAATGAGGATAAGGC	0.343													34	125					0	0	0	0	A	55653003	A	A	55653003	3	1	36	1	0	0	0	0	1	0	0	0	2953	1294	45	2	1309	2	CCPG1	15	55653003	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2571037	55653003	46878389	759	7559											
AQP9	366	broad.mit.edu	37	chr15	58465363	58465363	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtgggagcccagttcttggGagcctttgtgggggctgcaa	5	11	17	8	0	1	0	0	0	1	0	1	2	1	2	2	4	3	3	2	4	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:58465363G>C	uc002aez.2	+	3	692	c.335G>C	c.(334-336)GGA>GCA	p.G112A	ALDH1A2_uc010ugw.1_Intron|AQP9_uc010ugx.1_Missense_Mutation_p.G47A	NM_020980	NP_066190	O43315	AQP9_HUMAN	aquaporin 9	112	Helical; (Potential).				cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			ovary(1)	1				GBM - Glioblastoma multiforme(80;0.16)		CAGTTCTTGGGAGCCTTTGTG	0.473													74	271					0	0	0	0	C	58465363	C	C	58465363	3	2	36	1	0	0	0	0	1	0	0	0	833	1174	41	2	345	2	AQP9	15	58465363	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2812360	58465363	44066029	760	7560											
CILP	8483	broad.mit.edu	37	chr15	65489713	65489713	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgagtgccccccatgttgcGggatcgcacattcacttcca	8	10	9	14	2	1	1	1	1	0	0	3	2	2	2	4	1	2	2	4	1	0	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:65489713G>A	uc002aon.2	-	9	3092	c.2911C>T	c.(2911-2913)CGC>TGC	p.R971C		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	971					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CCCATGTTGCGGGATCGCACA	0.562													31	122					0	0	0	0	A	65489713	A	A	65489713	3	1	36	1	0	0	0	0	1	0	0	0	3444	1116	39	1	647	1	CILP	15	65489713	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	7024350	65489713	37041679	761	7561											
CILP	8483	broad.mit.edu	37	chr15	65499133	65499133	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcttacctggtgggcagagGaagcgtacggtgtaattaga	10	9	16	6	2	0	2	0	0	0	2	0	3	0	3	1	5	3	4	1	5	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:65499133G>A	uc002aon.2	-	4	592	c.411C>T	c.(409-411)TTC>TTT	p.F137F		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	137					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						GTGGGCAGAGGAAGCGTACGG	0.627													67	160					0	0	0	0	A	65499133	A	A	65499133	2	1	36	1	0	0	0	0	0	0	0	1	3444	1165	41	2		2	CILP	15	65499133	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	9420	65499133	37032259	762	7562											
THSD4	79875	broad.mit.edu	37	chr15	71535271	71535271	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagctacctttgacccatGatcaaggctaccctgcagct	10	9	7	15	0	1	2	1	2	0	0	1	2	1	2	4	1	5	4	4	1	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:71535271G>C	uc002atb.1	+	4	827	c.748G>C	c.(748-750)GAT>CAT	p.D250H	THSD4_uc002atd.1_5'UTR	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	250	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TTTGACCCATGATCAAGGCTA	0.582													27	127					0	0	0	0	C	71535271	C	C	71535271	3	2	36	1	0	0	0	0	1	0	0	0	15944	1290	45	2	762	2	THSD4	15	71535271	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	6036138	71535271	30996121	763	7563											
MYO9A	4649	broad.mit.edu	37	chr15	72170385	72170385	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatatcacatttacctttGtggctgtgcaatctgaagtc	11	15	7	8	0	2	1	1	1	1	0	3	1	2	1	1	1	2	2	1	1	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:72170385G>A	uc002atl.3	-	31	6400	c.5927C>T	c.(5926-5928)ACA>ATA	p.T1976I	MYO9A_uc002atk.2_Missense_Mutation_p.T771I|MYO9A_uc002atm.1_Missense_Mutation_p.T772I	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1976	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						ATTTACCTTTGTGGCTGTGCA	0.308													24	67					0	0	0	0	A	72170385	A	A	72170385	3	1	36	1	0	0	0	0	1	0	0	0	10137	1377	48	4	1767	4	MYO9A	15	72170385	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	635114	72170385	30361007	764	7564											
CELF6	60677	broad.mit.edu	37	chr15	72582346	72582346	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccccttgactcccgaacttCacaaaggcacagcctggggc	9	7	9	16	1	1	1	1	1	0	0	3	2	3	1	4	3	2	1	4	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:72582346C>T	uc002auh.2	-	5	847	c.537G>A	c.(535-537)GTG>GTA	p.V179V	uc002aug.2_Intron|CELF6_uc002auk.3_Intron|CELF6_uc010biv.1_RNA|CELF6_uc010biw.2_Silent_p.V66V|CELF6_uc010ukl.1_Silent_p.V64V|CELF6_uc010ukm.1_Silent_p.V179V|CELF6_uc002aui.2_Silent_p.V285V|CELF6_uc002auj.2_Silent_p.V66V	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	179	RRM 2.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						TCCCGAACTTCACAAAGGCAC	0.657													5	17					0	0	0	0	T	72582346	T	T	72582346	2	4	36	1	0	0	0	0	0	0	0	1	3235	813	29	2		2	CELF6	15	72582346	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	411961	72582346	29949046	765	7565											
MPI	4351	broad.mit.edu	37	chr15	75189514	75189514	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaggaagacccctacctctCaatctatgacccccctgtac	10	9	5	17	0	3	2	2	1	2	1	4	3	3	3	6	1	2	1	6	1	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:75189514C>G	uc002azc.1	+	7	1012	c.1007C>G	c.(1006-1008)TCA>TGA	p.S336*	MPI_uc002azd.1_Intron|MPI_uc010ulx.1_Nonsense_Mutation_p.S286*|MPI_uc002aze.1_Nonsense_Mutation_p.S275*	NM_002435	NP_002426	P34949	MPI_HUMAN	mannose-6- phosphate isomerase	336					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			ovary(2)	2						CCCTACCTCTCAATCTATGAC	0.517													64	116					0	0	0	0	G	75189514	G	G	75189514	4	3	36	1	0	0	0	0	0	1	0	0	9782	838	29	2	1033	2	MPI	15	75189514	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2607168	75189514	27341878	766	7566											
SIN3A	25942	broad.mit.edu	37	chr15	75668138	75668138	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccacattctccatggtcttCttgctgtttccttccttccc	3	18	4	16	0	3	0	0	0	3	0	8	0	7	0	5	1	1	2	5	1	0	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:75668138C>T	uc002bai.2	-	20	3718	c.3459G>A	c.(3457-3459)AAG>AAA	p.K1153K	SIN3A_uc002baj.2_Silent_p.K1153K|SIN3A_uc010uml.1_Silent_p.K1153K	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	1153					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						CCATGGTCTTCTTGCTGTTTC	0.468													65	222					0	0	0	0	T	75668138	T	T	75668138	2	4	36	1	0	0	0	0	0	0	0	1	14390	912	32	2		2	SIN3A	15	75668138	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	478624	75668138	26863254	767	7567											
MESDC1	59274	broad.mit.edu	37	chr15	81295691	81295691	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgccagtgaattccaattCtgtgaattagcaccccaccc	11	9	6	15	1	1	2	0	2	1	0	2	2	2	2	6	0	1	1	6	0	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:81295691C>G	uc002bfz.2	+	1	2397	c.1079C>G	c.(1078-1080)TCT>TGT	p.S360C		NM_022566	NP_072088	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	360											0						AATTCCAATTCTGTGAATTAG	0.517													3	19					0	0	0	0	G	81295691	G	G	81295691	3	3	36	1	0	0	0	0	1	0	0	0	9533	913	32	2	1081	2	MESDC1	15	81295691	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5627553	81295691	21235701	768	7568											
ALPK3	57538	broad.mit.edu	37	chr15	85360149	85360149	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caaggcgagggtcagtcacgGctggtgccaggaagagggct	9	5	18	9	2	2	1	2	0	0	1	2	3	2	2	1	6	1	2	1	6	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:85360149G>T	uc002ble.2	+	1	239	c.72G>T	c.(70-72)CGG>CGT	p.R24R		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	24					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GTCAGTCACGGCTGGTGCCAG	0.552													6	22					8.12818e-05	8.33939e-05	1	0	T	85360149	T	T	85360149	2	4	36	1	0	0	0	0	0	0	0	1	546	1190	42	4		4	ALPK3	15	85360149	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4064458	85360149	17171243	769	7569											
UNC45A	55898	broad.mit.edu	37	chr15	91488219	91488219	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagcgcctctattctcctCagcaagctctttgatgacct	8	13	7	13	1	4	3	1	3	3	0	5	3	4	3	3	0	3	2	3	0	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:91488219C>T	uc002bqg.2	+	9	1465	c.1125C>T	c.(1123-1125)CTC>CTT	p.L375L	UNC45A_uc002bqd.2_Silent_p.L360L	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	375					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CTATTCTCCTCAGCAAGCTCT	0.512													26	81					0	0	0	0	T	91488219	T	T	91488219	2	4	36	1	0	0	0	0	0	0	0	1	17056	813	29	2		2	UNC45A	15	91488219	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	6128070	91488219	11043173	770	7570											
TARSL2	123283	broad.mit.edu	37	chr15	102264441	102264441	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctgcgccacctcccgcgtGaggcacggcccctccgcctg	4	5	12	20	5	0	1	0	1	0	0	2	1	2	1	7	2	2	2	7	2	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr15:102264441G>C	uc002bxm.2	-	1	205	c.150C>G	c.(148-150)CTC>CTG	p.L50L	TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	50					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCTCCCGCGTGAGGCACGGCC	0.736													6	10					0	0	0	0	C	102264441	C	C	102264441	2	2	36	1	0	0	0	0	0	0	0	1	15627	1277	45	2		2	TARSL2	15	102264441	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	10776222	102264441	266951	771	7571											
WFIKKN1	117166	broad.mit.edu	37	chr16	682690	682690	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgacgacagcggcctcctgcGagggctttgtgtgcccacag	6	7	14	14	4	0	0	0	0	0	0	1	3	1	0	3	2	3	1	3	2	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:682690G>A	uc002cht.1	+	2	522	c.280G>A	c.(280-282)GAG>AAG	p.E94K	WFIKKN1_uc002chs.1_3'UTR	NM_053284	NP_444514	Q96NZ8	WFKN1_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz	94						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity				0		Hepatocellular(780;0.00335)				GGCCTCCTGCGAGGGCTTTGT	0.682													5	14					0	0	0	0	A	682690	A	A	682690	3	1	36	1	0	0	0	0	1	0	0	0	17426	1059	37	1	286	1	WFIKKN1	16	682690	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08		682690	89672063	772	7572											
CACNA1H	8912	broad.mit.edu	37	chr16	1261954	1261954	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgtgccacagcctgtgcaGaaccacaacccctggatgct	9	8	9	15	0	1	1	0	0	1	1	1	2	1	2	5	1	6	2	5	1	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:1261954G>C	uc002cks.2	+	25	4823	c.4575G>C	c.(4573-4575)CAG>CAC	p.Q1525H	CACNA1H_uc002ckt.2_Missense_Mutation_p.Q1525H|CACNA1H_uc002cku.2_Missense_Mutation_p.Q231H|CACNA1H_uc010brj.2_Missense_Mutation_p.Q231H|CACNA1H_uc002ckv.2_Missense_Mutation_p.Q231H	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1525	Extracellular (Potential).|III.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	AGCCTGTGCAGAACCACAACC	0.652													41	111					0	0	0	0	C	1261954	C	C	1261954	3	2	36	1	0	0	0	0	1	0	0	0	2557	933	33	2	4669	2	CACNA1H	16	1261954	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	579264	1261954	89092799	773	7573											
TRAF7	84231	broad.mit.edu	37	chr16	2222339	2222339	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catctttgaggtggacccccGagggtgccccttcaccatca	7	9	10	15	1	3	1	2	1	1	0	3	3	3	2	5	3	1	0	5	3	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:2222339G>A	uc002cow.2	+	8	722	c.623G>A	c.(622-624)CGA>CAA	p.R208Q		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	208					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						GTGGACCCCCGAGGGTGCCCC	0.687													9	34					0	0	0	0	A	2222339	A	A	2222339	3	1	36	1	0	0	0	0	1	0	0	0	16513	1058	37	1	649	1	TRAF7	16	2222339	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	960385	2222339	88132414	774	7574											
CASKIN1	57524	broad.mit.edu	37	chr16	2239055	2239055	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtcgatgtggccgtttttaGctgcgaggtgcaaagggctg	6	12	16	7	3	0	0	0	0	0	0	1	2	0	0	1	3	3	4	1	3	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:2239055G>T	uc010bsg.1	-	6	622	c.590C>A	c.(589-591)GCT>GAT	p.A197D		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	197	ANK 5.				signal transduction	cytoplasm				skin(2)	2						GCCGTTTTTAGCTGCGAGGTG	0.657													17	79					1.02788e-11	1.07257e-11	1	0	T	2239055	T	T	2239055	3	4	36	1	0	0	0	0	1	0	0	0	2678	971	34	4	3765	4	CASKIN1	16	2239055	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	16716	2239055	88115698	775	7575											
ABCA3	21	broad.mit.edu	37	chr16	2339481	2339481	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctcctcctcgatgagggctCcaatgccgtcggaggggtcc	5	8	14	14	3	0	1	0	1	0	0	6	3	4	2	5	4	1	2	5	4	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:2339481C>A	uc002cpy.1	-	20	3366	c.2654G>T	c.(2653-2655)GGA>GTA	p.G885V	ABCA3_uc010bsk.1_Missense_Mutation_p.G827V|ABCA3_uc010bsl.1_Missense_Mutation_p.G885V	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	885					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				GATGAGGGCTCCAATGCCGTC	0.682													3	11					0.000602214	0.000614259	1	0	A	2339481	A	A	2339481	3	1	36	1	0	0	0	0	1	0	0	0	33	855	30	2	2516	2	ABCA3	16	2339481	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	100426	2339481	88015272	776	7576											
SRRM2	23524	broad.mit.edu	37	chr16	2814163	2814163	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cacttagaaccccgccaaggGaaagaagtggtgctgggtca	12	6	13	10	1	1	2	1	0	0	2	1	3	1	3	3	3	2	1	3	3	5	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:2814163G>C	uc002crk.2	+	11	4183	c.3634G>C	c.(3634-3636)GAA>CAA	p.E1212Q	SRRM2_uc002crj.1_Missense_Mutation_p.E1116Q|SRRM2_uc002crl.1_Missense_Mutation_p.E1212Q|SRRM2_uc010bsu.1_Missense_Mutation_p.E1116Q	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1212	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCCGCCAAGGGAAAGAAGTGG	0.453													68	150					0	0	0	0	C	2814163	C	C	2814163	3	2	36	1	0	0	0	0	1	0	0	0	15235	1175	41	2	3672	2	SRRM2	16	2814163	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	474682	2814163	87540590	777	7577											
TFAP4	7023	broad.mit.edu	37	chr16	4310485	4310485	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagctgctgctgttcccgctCcagcttctcctggtgcagca	4	11	10	16	1	1	0	0	0	1	0	4	0	3	0	3	1	6	8	3	1	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:4310485C>T	uc010uxg.1	-	5	891	c.637G>A	c.(637-639)GAG>AAG	p.E213K		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	213	Gln-rich.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						tgttcccgctccagcttctcc	0.368													4	14					0	0	0	0	T	4310485	T	T	4310485	3	4	36	1	0	0	0	0	1	0	0	0	15858	864	30	2	391	2	TFAP4	16	4310485	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1496322	4310485	86044268	778	7578											
C16orf71	146562	broad.mit.edu	37	chr16	4797506	4797506	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaagcaacacatgaagctCtgtgccaaggggcagagcgc	13	4	14	10	1	1	2	0	1	1	1	1	3	1	3	1	3	5	3	1	3	4	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:4797506C>G	uc002cxn.2	+	9	1905	c.1443C>G	c.(1441-1443)CTC>CTG	p.L481L		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	481										central_nervous_system(1)	1						ACATGAAGCTCTGTGCCAAGG	0.677													22	39					0	0	0	0	G	4797506	G	G	4797506	2	3	36	1	0	0	0	0	0	0	0	1	1836	900	32	2		2	C16orf71	16	4797506	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	487021	4797506	85557247	779	7579											
PPL	5493	broad.mit.edu	37	chr16	4940880	4940880	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcaagttctgctccacctCacccaggagggacttctggg	7	9	11	14	0	3	0	1	0	2	0	4	2	4	2	3	3	2	3	3	3	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:4940880C>T	uc002cyd.1	-	17	2101	c.2011G>A	c.(2011-2013)GAG>AAG	p.E671K		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	671	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TGCTCCACCTCACCCAGGAGG	0.677													4	6					0	0	0	0	T	4940880	T	T	4940880	3	4	36	1	0	0	0	0	1	0	0	0	12394	835	29	2	3283	2	PPL	16	4940880	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	143374	4940880	85413873	780	7580											
PPL	5493	broad.mit.edu	37	chr16	4944472	4944472	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctttgcccttgtacctgtCagccagagccagggcctcag	6	9	11	15	0	2	1	2	0	0	1	2	1	2	1	6	1	4	1	6	1	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:4944472C>G	uc002cyd.1	-	12	1480	c.1390G>C	c.(1390-1392)GAC>CAC	p.D464H		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	464	Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TTGTACCTGTCAGCCAGAGCC	0.627													25	57					0	0	0	0	G	4944472	G	G	4944472	3	3	36	1	0	0	0	0	1	0	0	0	12394	826	29	2	3924	2	PPL	16	4944472	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3592	4944472	85410281	781	7581											
BFAR	51283	broad.mit.edu	37	chr16	14755859	14755859	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accgacaccttcctacctttCatccacaccatctgccctct	8	11	2	20	1	3	0	1	0	2	0	5	1	5	0	7	0	2	0	7	0	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:14755859C>T	uc002dco.2	+	6	1175	c.894C>T	c.(892-894)TTC>TTT	p.F298F	BFAR_uc002dcp.2_Silent_p.F173F|BFAR_uc010uzh.1_Silent_p.F170F	NM_016561	NP_057645	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	298	Lumenal (Potential).				anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			ovary(1)|skin(1)	2						TCCTACCTTTCATCCACACCA	0.542													76	212					0	0	0	0	T	14755859	T	T	14755859	2	4	36	1	0	0	0	0	0	0	0	1	1417	825	29	2		2	BFAR	16	14755859	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	9811387	14755859	75598894	782	7582											
PDXDC1	23042	broad.mit.edu	37	chr16	15100328	15100328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtaggcttgccattcattCtcgatatgaagacttcgtag	10	14	9	8	2	2	2	1	1	1	1	4	3	2	2	1	1	1	3	1	1	4	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:15100328C>T	uc002dda.3	+	6	691	c.467C>T	c.(466-468)TCT>TTT	p.S156F	PDXDC1_uc010uzl.1_Missense_Mutation_p.S141F|PDXDC1_uc010uzm.1_Missense_Mutation_p.S65F|PDXDC1_uc010bvc.1_Missense_Mutation_p.S97F|PDXDC1_uc002dcz.2_Missense_Mutation_p.S156F|PDXDC1_uc002ddb.3_Missense_Mutation_p.S129F|PDXDC1_uc010uzn.1_Missense_Mutation_p.S128F|PDXDC1_uc002ddc.2_Missense_Mutation_p.S156F	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	156					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GCCATTCATTCTCGATATGAA	0.398													46	293					0	0	0	0	T	15100328	T	T	15100328	3	4	36	1	0	0	0	0	1	0	0	0	11750	913	32	2	489	2	PDXDC1	16	15100328	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	344469	15100328	75254425	783	7583											
COQ7	10229	broad.mit.edu	37	chr16	19087180	19087180	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaatacgaggaacttcttCaggtatttatccgtgctcta	13	13	7	8	2	3	0	1	0	2	0	4	2	4	1	1	2	3	2	1	2	7	7	rs150852870		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:19087180C>T	uc002dfr.2	+	4	565	c.505C>T	c.(505-507)CAG>TAG	p.Q169*	COQ7_uc002dfs.2_Nonsense_Mutation_p.Q155*	NM_016138	NP_057222	Q99807	COQ7_HUMAN	COQ7 protein	169	2.|2 X approximate tandem repeats.				ubiquinone biosynthetic process	mitochondrial inner membrane|nucleus	oxidoreductase activity|transition metal ion binding			skin(1)	1						GGAACTTCTTCAGGTATTTAT	0.448													19	66					0	0	0	0	T	19087180	T	T	19087180	4	4	36	1	0	0	0	0	0	1	0	0	3765	827	29	2	519	2	COQ7	16	19087180	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3986852	19087180	71267573	784	7584											
ACSM2B	348158	broad.mit.edu	37	chr16	20570614	20570614	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaggcactcggggcagcatCactgccacacgatccccacg	9	5	10	17	3	2	0	2	0	0	0	4	1	3	0	3	3	2	3	3	3	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:20570614C>G	uc002dhj.3	-	4	543	c.333G>C	c.(331-333)GTG>GTC	p.V111V	ACSM2B_uc002dhk.3_Silent_p.V111V|ACSM2B_uc010bwf.1_Silent_p.V111V	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	111					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GGGGCAGCATCACTGCCACAC	0.552													15	36					0	0	0	0	G	20570614	G	G	20570614	2	3	36	1	0	0	0	0	0	0	0	1	184	813	29	2		2	ACSM2B	16	20570614	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1483434	20570614	69784139	785	7585											
DNAH3	55567	broad.mit.edu	37	chr16	20944735	20944735	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagattccccaatctgcatcGttttcctgtcccaacgggca	8	11	8	14	2	1	1	0	0	1	1	5	2	4	1	4	1	2	3	4	1	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:20944735G>A	uc010vbe.1	-	62	12092	c.12092C>T	c.(12091-12093)ACG>ATG	p.T4031M	DNAH3_uc010vbd.1_Missense_Mutation_p.T1466M	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	4031					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AATCTGCATCGTTTTCCTGTC	0.507													52	133					0	0	0	0	A	20944735	A	A	20944735	3	1	36	1	0	0	0	0	1	0	0	0	4625	1145	40	1	261	1	DNAH3	16	20944735	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	374121	20944735	69410018	786	7586											
DNAH3	55567	broad.mit.edu	37	chr16	20975168	20975168	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatggtcaatgatgtacttGatgcgcagattcagttcctc	11	13	9	8	1	2	3	2	2	0	1	4	3	3	3	1	1	2	3	1	1	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:20975168G>C	uc010vbe.1	-	53	10038	c.10038C>G	c.(10036-10038)ATC>ATG	p.I3346M	DNAH3_uc010vbd.1_Missense_Mutation_p.I781M	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3346					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TGATGTACTTGATGCGCAGAT	0.483													40	135					0	0	0	0	C	20975168	C	C	20975168	3	2	36	1	0	0	0	0	1	0	0	0	4625	1280	45	2	2351	2	DNAH3	16	20975168	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	30433	20975168	69379585	787	7587											
ERN2	10595	broad.mit.edu	37	chr16	23706664	23706664	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccgaaccaggccaaagcactCgcggaggagccgcttgacag	11	3	13	14	4	0	1	0	1	0	0	1	4	0	3	4	3	3	2	4	3	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:23706664C>G	uc002dma.3	-	15	1970	c.1801G>C	c.(1801-1803)GAG>CAG	p.E601Q	ERN2_uc010bxp.2_Missense_Mutation_p.E549Q	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	553	Protein kinase.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CCAAAGCACTCGCGGAGGAGC	0.627													5	12					0	0	0	0	G	23706664	G	G	23706664	3	3	36	1	0	0	0	0	1	0	0	0	5262	893	31	3	1155	3	ERN2	16	23706664	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2731496	23706664	66648089	788	7588											
ARHGAP17	55114	broad.mit.edu	37	chr16	24958901	24958901	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtctgagcaagctttgcaagGaacttgatcaaatatctagg	13	11	10	7	0	3	2	1	2	2	0	3	3	3	3	0	2	4	3	0	2	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:24958901G>T	uc002dnb.2	-	14	1236	c.1143C>A	c.(1141-1143)TTC>TTA	p.F381L	ARHGAP17_uc002dna.2_Missense_Mutation_p.F108L|ARHGAP17_uc002dnc.2_Missense_Mutation_p.F381L|ARHGAP17_uc010vcf.1_Missense_Mutation_p.F202L	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	381	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		GCTTTGCAAGGAACTTGATCA	0.468													20	98					1.40151e-16	1.48395e-16	1	0	T	24958901	T	T	24958901	3	4	36	1	0	0	0	0	1	0	0	0	867	1165	41	2	1530	2	ARHGAP17	16	24958901	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1252237	24958901	65395852	789	7589											
ZKSCAN2	342357	broad.mit.edu	37	chr16	25251184	25251184	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttcccttatgtgggttctCagggcaatacagagatggag	9	12	12	8	0	1	1	1	0	1	1	3	3	2	2	1	3	1	2	1	3	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:25251184C>T	uc002dod.3	-	7	3264	c.2857G>A	c.(2857-2859)GAG>AAG	p.E953K	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.E749K	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	953					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		TGTGGGTTCTCAGGGCAATAC	0.423													50	159					0	0	0	0	T	25251184	T	T	25251184	3	4	36	1	0	0	0	0	1	0	0	0	17754	835	29	2	50	2	ZKSCAN2	16	25251184	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	292283	25251184	65103569	790	7590											
HS3ST4	9951	broad.mit.edu	37	chr16	26147555	26147555	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attttcagtgggaacaggaaGagggtgataaatgaggctag	14	9	15	3	0	1	3	1	2	0	1	1	5	1	5	0	4	1	1	0	4	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:26147555G>C	uc002dof.2	+	2	1749	c.1357G>C	c.(1357-1359)GAG>CAG	p.E453Q		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	453	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		GGAACAGGAAGAGGGTGATAA	0.463													7	30					0	0	0	0	C	26147555	C	C	26147555	3	2	36	1	0	0	0	0	1	0	0	0	7406	943	33	2	1363	2	HS3ST4	16	26147555	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	896371	26147555	64207198	791	7591											
GDPD3	79153	broad.mit.edu	37	chr16	30123849	30123849	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcccttgctctcacctggaGagaagtaaacctccagcttc	10	9	8	14	0	1	1	1	0	1	1	4	3	2	2	4	1	4	3	4	1	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:30123849G>C	uc002dwp.2	-	4	438	c.359C>G	c.(358-360)TCT>TGT	p.S120C	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Missense_Mutation_p.S58C|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	120	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						CTCACCTGGAGAGAAGTAAAC	0.612											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	87					0	0	0	0	C	30123849	C	C	30123849	3	2	36	1	0	0	0	0	1	0	0	0	6362	942	33	2	625	2	GDPD3	16	30123849	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3976294	30123849	60230904	792	7592											
SRCAP	10847	broad.mit.edu	37	chr16	30712176	30712176	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccctcccctgctcaccctCagctcccagtcctacagaca	7	7	5	22	0	2	1	2	0	0	1	5	1	5	1	7	0	3	2	7	0	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:30712176C>T	uc002dze.1	+	3	416	c.31C>T	c.(31-33)CAG>TAG	p.Q11*		NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	11					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGCTCACCCTCAGCTCCCAGT	0.552													23	90					0	0	0	0	T	30712176	T	T	30712176	4	4	36	1	0	0	0	0	0	1	0	0	15201	827	29	2	33	2	SRCAP	16	30712176	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	588327	30712176	59642577	793	7593											
FUS	2521	broad.mit.edu	37	chr16	31193962	31193962	+	Frame_Shift_Del	DEL	C	-	-																															ctatggccagagcagctattCttcttatggccagagccaga																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:31193962delC	uc002ebf.2	+	3	250	c.167delC	c.(166-168)TCTfs	p.S56fs	FUS_uc002ebe.1_Frame_Shift_Del_p.S56fs|FUS_uc002ebh.2_Frame_Shift_Del_p.S56fs|FUS_uc002ebg.2_5'UTR|FUS_uc002ebi.2_Frame_Shift_Del_p.S56fs|FUS_uc002ebj.2_5'UTR|FUS_uc010vfi.1_Frame_Shift_Del_p.S56fs	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	56	Gln/Gly/Ser/Tyr-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		AGCAGCTATTCTTCTTATGGC	0.448			T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								---	---	---								-	31193962	-	-	31193962	7	5	36	1	0	1	0	1	0	0	0	0	6134	913	32	0	177	0	FUS	16	31193962	Frame_Shift_Del	DEL	C	TCGA-CN-4723-01A-01D-1434-08	481786	31193962	59160791	794	7594											
MYLK3	91807	broad.mit.edu	37	chr16	46763019	46763019	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtggctgagctggttcatGatgttgatctcgttcttcac	6	15	11	9	2	4	3	2	3	2	0	5	3	4	3	0	2	1	5	0	2	0	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:46763019G>A	uc002eei.3	-	7	1805	c.1689C>T	c.(1687-1689)ATC>ATT	p.I563I	MYLK3_uc010vge.1_Silent_p.I222I|MYLK3_uc002eej.1_Silent_p.I222I	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	563	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GCTGGTTCATGATGTTGATCT	0.537													35	101					0	0	0	0	A	46763019	A	A	46763019	2	1	36	1	0	0	0	0	0	0	0	1	10111	1280	45	2		2	MYLK3	16	46763019	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	15569057	46763019	43591734	795	7595											
ITFG1	81533	broad.mit.edu	37	chr16	47488014	47488014	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtcagaaggacatccatttGagaatctccatcataatccc	13	11	6	11	0	3	2	2	1	1	2	6	4	5	3	3	1	0	0	3	1	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:47488014G>A	uc002eet.2	-	3	399	c.337C>T	c.(337-339)CAA>TAA	p.Q113*	ITFG1_uc010vgh.1_5'UTR|ITFG1_uc010cbf.1_5'UTR	NM_030790	NP_110417	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	113						extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				ACATCCATTTGAGAATCTCCA	0.363													44	179					0	0	0	0	A	47488014	A	A	47488014	4	1	36	1	0	0	0	0	0	1	0	0	7908	1299	45	2	1565	2	ITFG1	16	47488014	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	724995	47488014	42866739	796	7596											
N4BP1	9683	broad.mit.edu	37	chr16	48596001	48596001	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtgtgagtgtcaaaagttCttttttcaaggaagtgggca	10	15	12	4	0	3	1	2	1	1	0	3	2	3	2	0	2	0	2	0	2	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:48596001C>G	uc002efp.2	-	2	790	c.553G>C	c.(553-555)GAA>CAA	p.E185Q		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	185					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				GTCAAAAGTTCTTTTTTCAAG	0.368													19	74					0	0	0	0	G	48596001	G	G	48596001	3	3	36	1	0	0	0	0	1	0	0	0	10162	922	32	2	2161	2	N4BP1	16	48596001	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1107987	48596001	41758752	797	7597											
N4BP1	9683	broad.mit.edu	37	chr16	48596101	48596101	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttcacctctgattctttCtgactactgggtaggttctc	5	18	7	11	0	5	2	1	2	4	0	6	2	5	2	1	2	1	2	1	2	2	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:48596101C>T	uc002efp.2	-	2	690	c.453G>A	c.(451-453)CAG>CAA	p.Q151Q		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	151					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				CTGATTCTTTCTGACTACTGG	0.398													27	117					0	0	0	0	T	48596101	T	T	48596101	2	4	36	1	0	0	0	0	0	0	0	1	10162	912	32	2		2	N4BP1	16	48596101	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	100	48596101	41758652	798	7598											
CYLD	1540	broad.mit.edu	37	chr16	50783939	50783939	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaattgtgaggagaggttCagcctgtttaaaaacagaaa	16	9	10	6	0	1	3	1	1	0	2	1	4	1	3	2	2	2	2	2	2	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:50783939C>A	uc002egp.1	+	4	745	c.330C>A	c.(328-330)TTC>TTA	p.F110L	CYLD_uc002egn.1_Missense_Mutation_p.F110L|CYLD_uc002ego.2_Missense_Mutation_p.F110L|CYLD_uc010cbs.1_Missense_Mutation_p.F110L|CYLD_uc002egq.1_Missense_Mutation_p.F110L|CYLD_uc002egr.1_Missense_Mutation_p.F110L|CYLD_uc002egs.1_Missense_Mutation_p.F110L	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	110	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				AGGAGAGGTTCAGCCTGTTTA	0.398			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				34	95					5.90632e-09	6.13696e-09	1	0	A	50783939	A	A	50783939	3	1	36	1	0	0	0	0	1	0	0	0	4160	825	29	2	332	2	CYLD	16	50783939	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2187838	50783939	39570814	799	7599											
CES7	221223	broad.mit.edu	37	chr16	55899899	55899899	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagaaacacttatggctccCgcggactcgccaaagatggt	11	8	10	12	3	0	2	0	0	0	2	2	3	1	3	2	3	1	1	2	3	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:55899899C>T	uc002eip.2	-	5	830	c.681G>A	c.(679-681)GCG>GCA	p.A227A	CES7_uc002eio.2_Silent_p.A227A|CES7_uc002eiq.2_5'UTR|CES7_uc002eir.2_Silent_p.A121A	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	227						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		TTATGGCTCCCGCGGACTCGC	0.478													12	38					0	0	0	0	T	55899899	T	T	55899899	2	4	36	1	0	0	0	0	0	0	0	1	3287	639	23	1		1	CES7	16	55899899	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5115960	55899899	34454854	800	7600											
CETP	1071	broad.mit.edu	37	chr16	56996944	56996944	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccacgagactgccaaggtGatccagaccgccttccagcg	11	5	10	15	3	0	3	0	1	0	2	2	4	2	3	6	1	3	0	6	1	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:56996944G>C	uc002eki.2	+	2	198	c.141G>C	c.(139-141)GTG>GTC	p.V47V	CETP_uc002ekj.2_Silent_p.V47V	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	47					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						CTGCCAAGGTGATCCAGACCG	0.617													19	86					0	0	0	0	C	56996944	C	C	56996944	2	2	36	1	0	0	0	0	0	0	0	1	3292	1277	45	2		2	CETP	16	56996944	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1097045	56996944	33357809	801	7601											
RANBP10	57610	broad.mit.edu	37	chr16	67760383	67760383	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcaagaacccaggcctgctCgggccatgagccggagacac	11	3	13	14	2	0	3	0	1	0	2	1	4	0	3	4	3	4	2	4	3	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:67760383C>T	uc002eud.2	-	14	1927	c.1811G>A	c.(1810-1812)CGA>CAA	p.R604Q	RANBP10_uc010ceo.2_Missense_Mutation_p.R375Q|RANBP10_uc010vju.1_Missense_Mutation_p.R578Q|RANBP10_uc010vjv.1_Missense_Mutation_p.R517Q	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	604										ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		CAGGCCTGCTCGGGCCATGAG	0.622													3	22					0	0	0	0	T	67760383	T	T	67760383	3	4	36	1	0	0	0	0	1	0	0	0	13091	884	31	1	55	1	RANBP10	16	67760383	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	10763439	67760383	22594370	802	7602											
HAS3	3038	broad.mit.edu	37	chr16	69148601	69148601	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagtcttacttccgggagtGgctctacaactctctgtggt	7	13	10	11	1	3	0	0	0	3	0	5	1	4	1	1	3	3	1	1	3	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:69148601G>A	uc010cfh.2	+	4	1318	c.1094G>A	c.(1093-1095)TGG>TAG	p.W365*	HAS3_uc002ewk.2_Intron|HAS3_uc002ewl.2_Nonsense_Mutation_p.W365*	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	365	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		TTCCGGGAGTGGCTCTACAAC	0.547													4	183					0	0	0	0	A	69148601	A	A	69148601	4	1	36	1	0	0	0	0	0	1	0	0	7002	1357	47	4	1104	4	HAS3	16	69148601	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1388218	69148601	21206152	803	7603											
HYDIN	54768	broad.mit.edu	37	chr16	71054110	71054110	+	Silent	SNP	C	T	T																															ggcagcagggatttatcagtCtcacatataaagaagggtcc																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:71054110C>T	uc002ezr.2	-	22	3425	c.3297G>A	c.(3295-3297)GAG>GAA	p.E1099E		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1099										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ATTTATCAGTCTCACATATAA	0.502													9	25					0	0	0	0	T	71054110	T	T	71054110	2	4	36	1	0	0	0	0	0	0	0	1	7506	912	32	2		2	HYDIN	16	71054110	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1905509	71054110	19300643	804	7604	15	2									
HYDIN	54768	broad.mit.edu	37	chr16	71054112	71054112	+	Missense_Mutation	SNP	C	T	T																															cagcagggatttatcagtctCacatataaagaagggtccag																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:71054112C>T	uc002ezr.2	-	22	3423	c.3295G>A	c.(3295-3297)GAG>AAG	p.E1099K		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1099										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TTATCAGTCTCACATATAAAG	0.507													10	24					0	0	0	0	T	71054112	T	T	71054112	3	4	36	1	0	0	0	0	1	0	0	0	7506	835	29	2	12327	2	HYDIN	16	71054112	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2	71054112	19300641	805	7605	15	2									
CALB2	794	broad.mit.edu	37	chr16	71418697	71418697	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttgcagggcatgaagctGacctcagaggagtttaacgc	10	10	12	9	1	2	3	1	2	1	1	2	4	2	4	1	2	3	4	1	2	2	4	rs143688092		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:71418697G>A	uc002faa.3	+	9	655	c.585G>A	c.(583-585)CTG>CTA	p.L195L	CALB2_uc010vme.1_RNA|CALB2_uc002fac.3_Intron	NM_001740	NP_001731	P22676	CALB2_HUMAN	calbindin 2 isoform 1	195	EF-hand 5.						calcium ion binding				0		Ovarian(137;0.125)				GCATGAAGCTGACCTCAGAGG	0.388													52	132					0	0	0	0	A	71418697	A	A	71418697	2	1	36	1	0	0	0	0	0	0	0	1	2586	1277	45	2		2	CALB2	16	71418697	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	364585	71418697	18936056	806	7606											
GLG1	2734	broad.mit.edu	37	chr16	74516954	74516954	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agatgaaatactgcagctctAagagacggtgttcacagtct	13	10	10	8	1	3	3	1	1	2	2	3	4	3	3	0	1	3	3	0	1	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:74516954A>G	uc002fcy.3	-	10	1690	c.1640T>C	c.(1639-1641)TTA>TCA	p.L547S	GLG1_uc002fcx.2_Missense_Mutation_p.L547S|GLG1_uc002fcw.3_Missense_Mutation_p.L536S|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	547	Extracellular (Potential).|Cys-rich GLG1 8.					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						CTGCAGCTCTAAGAGACGGTG	0.403													35	96					0	0	0	0	G	74516954	G	G	74516954	3	3	36	1	0	0	0	0	1	0	0	0	6473	372	13	5	2047	5	GLG1	16	74516954	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	3098257	74516954	15837799	807	7607											
VAT1L	57687	broad.mit.edu	37	chr16	77859251	77859251	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atgacatgagcttctccgagGctgctgcattccccatgaac	9	10	9	13	1	1	3	0	3	1	0	3	4	2	3	3	1	4	4	3	1	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:77859251G>A	uc002ffg.1	+	3	569	c.472G>A	c.(472-474)GCT>ACT	p.A158T		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	158							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						CTTCTCCGAGGCTGCTGCATT	0.537													19	63					0	0	0	0	A	77859251	A	A	77859251	3	1	36	1	0	0	0	0	1	0	0	0	17198	1203	42	4	482	4	VAT1L	16	77859251	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3342297	77859251	12495502	808	7608											
MBTPS1	8720	broad.mit.edu	37	chr16	84125404	84125404	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtttaacacgtcgatcttcTttaaaatggcatagttgaag	12	14	9	6	2	2	1	0	1	2	0	3	2	2	1	0	2	1	3	0	2	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:84125404T>C	uc002fhi.2	-	7	1398	c.896A>G	c.(895-897)AAG>AGG	p.K299R		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	299	Serine protease.|Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						GTCGATCTTCTTTAAAATGGC	0.423													15	83					0	0	0	0	C	84125404	C	C	84125404	3	2	36	1	0	0	0	0	1	0	0	0	9414	1609	56	5	2330	5	MBTPS1	16	84125404	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	6266153	84125404	6229349	809	7609											
FOXC2	2303	broad.mit.edu	37	chr16	86601587	86601587	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaaggtggtgatcaagagcGaggcggcgtccccggcgctg	8	5	18	10	5	1	3	1	1	0	2	2	4	2	3	2	5	1	1	2	5	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr16:86601587G>A	uc002fjq.2	+	1	731	c.646G>A	c.(646-648)GAG>AAG	p.E216K		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	216					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						GATCAAGAGCGAGGCGGCGTC	0.756									Late-onset_Hereditary_Lymphedema				4	2					0	0	0	0	A	86601587	A	A	86601587	3	1	36	1	0	0	0	0	1	0	0	0	6027	1059	37	1	648	1	FOXC2	16	86601587	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2476183	86601587	3753166	810	7610											
PRPF8	10594	broad.mit.edu	37	chr17	1586884	1586884	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtcatgtctccatggtctCgaatgatcttcctgacatgt	7	15	9	10	1	4	2	1	2	3	0	7	3	5	2	2	2	0	0	2	2	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:1586884C>T	uc002fte.2	-	3	326	c.212G>A	c.(211-213)CGA>CAA	p.R71Q		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	71						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCCATGGTCTCGAATGATCTT	0.473													59	160					0	0	0	0	T	1586884	T	T	1586884	3	4	36	1	0	0	0	0	1	0	0	0	12637	884	31	1	6959	1	PRPF8	17	1586884	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08		1586884	79608326	811	7611											
WDR81	124997	broad.mit.edu	37	chr17	1635682	1635682	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accatcagcctcatcgccctCatctgcctgcgcattggaca	8	9	7	17	2	4	0	3	0	1	0	5	1	4	1	4	1	3	1	4	1	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:1635682C>T	uc002fti.2	+	5	801	c.540C>T	c.(538-540)CTC>CTT	p.L180L	WDR81_uc002fth.2_Silent_p.L356L|WDR81_uc010vqp.1_Silent_p.L204L|WDR81_uc002ftj.2_Silent_p.L1407L|WDR81_uc010vqq.1_Silent_p.L38L	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	180										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TCATCGCCCTCATCTGCCTGC	0.597													52	113					0	0	0	0	T	1635682	T	T	1635682	2	4	36	1	0	0	0	0	0	0	0	1	17398	813	29	2		2	WDR81	17	1635682	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	48798	1635682	79559528	812	7612											
SMTNL2	342527	broad.mit.edu	37	chr17	4498466	4498466	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctggtgacaccaccccagtCgcccgtgtccccgcagccgc	5	5	11	20	4	0	1	0	1	0	0	2	1	1	1	7	1	1	2	7	1	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:4498466C>T	uc002fyf.1	+	5	900	c.833C>T	c.(832-834)TCG>TTG	p.S278L	SMTNL2_uc002fye.2_Missense_Mutation_p.S134L	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	278											0				READ - Rectum adenocarcinoma(115;0.0325)		CCACCCCAGTCGCCCGTGTCC	0.677													15	47					0	0	0	0	T	4498466	T	T	4498466	3	4	36	1	0	0	0	0	1	0	0	0	14880	893	31	1	851	1	SMTNL2	17	4498466	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2862784	4498466	76696744	813	7613											
ZNF232	7775	broad.mit.edu	37	chr17	5012997	5012997	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttcccaggtagcctggtctCatactcacaagactgttcct	8	12	8	13	0	2	1	2	0	1	1	5	1	4	1	3	2	2	3	3	2	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:5012997C>G	uc002gas.2	-	3	863	c.109G>C	c.(109-111)GAG>CAG	p.E37Q	ZNF232_uc002gar.1_Missense_Mutation_p.E64Q|ZNF232_uc002gat.2_Missense_Mutation_p.E64Q|ZNF232_uc010vsv.1_Missense_Mutation_p.E64Q	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	37					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						AGCCTGGTCTCATACTCACAA	0.537													29	91					0	0	0	0	G	5012997	G	G	5012997	3	3	36	1	0	0	0	0	1	0	0	0	17852	835	29	2	1156	2	ZNF232	17	5012997	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	514531	5012997	76182213	814	7614											
ZNF594	84622	broad.mit.edu	37	chr17	5086386	5086386	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgatgtctgatgaggtctGaggtgccctggaaattccta	8	12	12	9	0	2	4	0	4	2	0	3	5	3	5	3	3	1	0	3	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:5086386G>C	uc010cla.1	-	2	1322	c.1166C>G	c.(1165-1167)TCA>TGA	p.S389*		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	389	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						GATGAGGTCTGAGGTGCCCTG	0.438													162	408					0	0	0	0	C	5086386	C	C	5086386	4	2	36	1	0	0	0	0	0	1	0	0	18091	1294	45	2	1261	2	ZNF594	17	5086386	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	73389	5086386	76108824	815	7615											
ZNF594	84622	broad.mit.edu	37	chr17	5087056	5087056	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tataataagatttgaactttGattagagtctttcccacatt	13	17	5	6	0	1	4	0	2	1	2	2	4	2	4	1	0	1	0	1	0	5	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:5087056G>C	uc010cla.1	-	2	652	c.496C>G	c.(496-498)CAA>GAA	p.Q166E		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	166	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TTTGAACTTTGATTAGAGTCT	0.338													29	131					0	0	0	0	C	5087056	C	C	5087056	3	2	36	1	0	0	0	0	1	0	0	0	18091	1299	45	2	1931	2	ZNF594	17	5087056	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	670	5087056	76108154	816	7616											
ACADVL	37	broad.mit.edu	37	chr17	7128359	7128359	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccgcaacttcaaaagcatCtccaaggccttggtggagcg	11	8	10	12	2	2	0	1	0	1	0	3	1	2	1	3	3	4	2	3	3	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:7128359C>T	uc002gev.2	+	20	2062	c.1911C>T	c.(1909-1911)ATC>ATT	p.I637I	ACADVL_uc010vtp.1_Silent_p.I647I|ACADVL_uc002gew.2_Silent_p.I615I|ACADVL_uc002gex.2_Silent_p.I561I|uc002gey.1_5'Flank|MIR324_hsa-mir-324|MI0000813_5'Flank	NM_000018	NP_000009	P49748	ACADV_HUMAN	acyl-Coenzyme A dehydrogenase, very long chain	637					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			ovary(3)	3						TCAAAAGCATCTCCAAGGCCT	0.617													38	142					0	0	0	0	T	7128359	T	T	7128359	2	4	36	1	0	0	0	0	0	0	0	1	116	903	32	2		2	ACADVL	17	7128359	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2041303	7128359	74066851	817	7617											
C17orf74	201243	broad.mit.edu	37	chr17	7330205	7330205	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtccccgtggggcacagcCcttacccctcagtgggctgg	4	7	15	15	1	1	0	1	0	0	0	2	0	2	0	5	5	2	2	5	5	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:7330205C>A	uc002ggw.2	+	3	968	c.895C>A	c.(895-897)CCT>ACT	p.P299T	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	299						integral to membrane					0		Prostate(122;0.157)				GGGGCACAGCCCTTACCCCTC	0.687													13	62					1.52009e-12	1.59161e-12	1	0	A	7330205	A	A	7330205	3	1	36	1	0	0	0	0	1	0	0	0	1887	623	22	4	905	4	C17orf74	17	7330205	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	201846	7330205	73865005	818	7618											
TP53	7157	broad.mit.edu	37	chr17	7577556	7577556	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccggttcatgccgcccatgCaggaactgttacacatgtag	9	10	10	12	2	1	0	1	0	0	0	2	1	2	1	3	2	4	4	3	2	3	3	rs121912655		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:7577556C>A	uc002gim.2	-	7	919	c.725G>T	c.(724-726)TGC>TTC	p.C242F	TP53_uc002gig.1_Missense_Mutation_p.C242F|TP53_uc002gih.2_Missense_Mutation_p.C242F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C110F|TP53_uc010cng.1_Missense_Mutation_p.C110F|TP53_uc002gii.1_Missense_Mutation_p.C110F|TP53_uc010cnh.1_Missense_Mutation_p.C242F|TP53_uc010cni.1_Missense_Mutation_p.C242F|TP53_uc002gij.2_Missense_Mutation_p.C242F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C149F|TP53_uc002gio.2_Missense_Mutation_p.C110F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	242	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).	Zinc.	C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(63)|p.C242Y(37)|p.C242S(25)|p.C242fs*5(16)|p.C242R(11)|p.C242W(7)|p.0?(7)|p.N239_C242delNSSC(3)|p.C242*(3)|p.C242C(2)|p.C242G(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241_G245delSCMGG(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGCCCATGCAGGAACTGTT	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	46					1.30475e-32	1.40706e-32	1	0	A	7577556	A	A	7577556	3	1	36	1	0	0	0	0	1	0	0	0	16448	710	25	4	565	4	TP53	17	7577556	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	247351	7577556	73617654	819	7619											
MYH10	4628	broad.mit.edu	37	chr17	8413181	8413181	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcagaatctcctcttccatCttcttgatcttggcctctgc	6	15	6	14	0	6	2	0	1	6	1	8	2	7	2	3	1	2	1	3	1	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:8413181C>G	uc002gll.2	-	23	3042	c.2946G>C	c.(2944-2946)AAG>AAC	p.K982N	MYH10_uc002glm.2_Missense_Mutation_p.K1013N|MYH10_uc010cnx.2_Missense_Mutation_p.K991N	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	982	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CCTCTTCCATCTTCTTGATCT	0.448													53	164					0	0	0	0	G	8413181	G	G	8413181	3	3	36	1	0	0	0	0	1	0	0	0	10083	912	32	2	3060	2	MYH10	17	8413181	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	835625	8413181	72782029	820	7620											
MYH10	4628	broad.mit.edu	37	chr17	8449949	8449949	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgagtaaactccatcacattCatcccaagaagatggcagag	15	7	8	11	1	2	3	2	0	0	3	4	4	4	3	2	1	1	2	2	1	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:8449949C>T	uc002gll.2	-	11	1257	c.1161G>A	c.(1159-1161)ATG>ATA	p.M387I	MYH10_uc002glm.2_Missense_Mutation_p.M397I|MYH10_uc010cnx.2_Missense_Mutation_p.M396I	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	387	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CCATCACATTCATCCCAAGAA	0.428													25	62					0	0	0	0	T	8449949	T	T	8449949	3	4	36	1	0	0	0	0	1	0	0	0	10083	826	29	2	4893	2	MYH10	17	8449949	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	36768	8449949	72745261	821	7621											
MYH10	4628	broad.mit.edu	37	chr17	8457276	8457276	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttatgaaaaaggatacatgTttcaatgttggccccaacga	14	12	8	7	1	1	1	1	1	0	0	1	3	1	2	2	2	2	2	2	2	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:8457276T>C	uc002gll.2	-	7	883	c.787A>G	c.(787-789)ACA>GCA	p.T263A	MYH10_uc002glm.2_Missense_Mutation_p.T273A|MYH10_uc010cnx.2_Missense_Mutation_p.T272A|MYH10_uc010cny.1_RNA	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	263	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						AGGATACATGTTTCAATGTTG	0.338													105	96					0	0	0	0	C	8457276	C	C	8457276	3	2	36	1	0	0	0	0	1	0	0	0	10083	1725	60	5	5283	5	MYH10	17	8457276	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	7327	8457276	72737934	822	7622											
MFSD6L	162387	broad.mit.edu	37	chr17	8700928	8700928	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgacaaagctgcccaggctaCagccactcccgtaaaagtgg	12	5	10	14	2	0	0	0	0	0	0	1	1	1	0	3	2	4	3	3	2	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:8700928C>T	uc002glp.1	-	1	1659	c.1511G>A	c.(1510-1512)TGT>TAT	p.C504Y		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	504	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						GCCCAGGCTACAGCCACTCCC	0.632													18	28					0	0	0	0	T	8700928	T	T	8700928	3	4	36	1	0	0	0	0	1	0	0	0	9589	478	17	4	253	4	MFSD6L	17	8700928	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	243652	8700928	72494282	823	7623											
MYH13	8735	broad.mit.edu	37	chr17	10209920	10209920	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgctggtgtcctgttccttCtttagctcctcagccatcat	4	15	8	14	1	3	0	2	0	1	0	6	0	6	0	4	1	2	3	4	1	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:10209920C>G	uc002gmk.1	-	37	5412	c.5322G>C	c.(5320-5322)AAG>AAC	p.K1774N		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1774	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CCTGTTCCTTCTTTAGCTCCT	0.577													53	126					0	0	0	0	G	10209920	G	G	10209920	3	3	36	1	0	0	0	0	1	0	0	0	10085	912	32	2	514	2	MYH13	17	10209920	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1508992	10209920	70985290	824	7624											
MYH4	4622	broad.mit.edu	37	chr17	10358497	10358497	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gactggtgataccttggtatGaccgaatttgtactgggtgt	8	14	13	6	1	0	2	0	2	0	0	0	4	0	2	2	3	2	2	2	3	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:10358497G>C	uc002gmn.2	-	20	2401	c.2290C>G	c.(2290-2292)CAT>GAT	p.H764D	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	764	Myosin head-like.|Actin-binding (By similarity).				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						ACCTTGGTATGACCGAATTTG	0.383													3	151					0	0	0	0	C	10358497	C	C	10358497	3	2	36	1	0	0	0	0	1	0	0	0	10090	1290	45	2	3613	2	MYH4	17	10358497	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	148577	10358497	70836713	825	7625											
MYH1	4619	broad.mit.edu	37	chr17	10415430	10415430	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttggtgacatactcattgccGaccttgaccctagggtagca	9	11	10	11	1	1	2	1	2	0	0	1	3	1	2	3	2	3	2	3	2	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:10415430G>A	uc002gmo.2	-	13	1321	c.1227C>T	c.(1225-1227)GTC>GTT	p.V409V	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	409	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						ACTCATTGCCGACCTTGACCC	0.458													133	321					0	0	0	0	A	10415430	A	A	10415430	2	1	36	1	0	0	0	0	0	0	0	1	10082	1045	37	1		1	MYH1	17	10415430	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	56933	10415430	70779780	826	7626											
MYH2	4620	broad.mit.edu	37	chr17	10428570	10428570	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctaaagcagcctgaagttCacacttttcttgttccactt	9	16	5	11	0	3	1	1	1	2	0	4	1	4	1	2	0	2	3	2	0	3	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:10428570C>G	uc010coi.2	-	33	4761	c.4633G>C	c.(4633-4635)GAA>CAA	p.E1545Q	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E1545Q|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1545	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GCCTGAAGTTCACACTTTTCT	0.363													35	152					0	0	0	0	G	10428570	G	G	10428570	3	3	36	1	0	0	0	0	1	0	0	0	10088	835	29	2	1224	2	MYH2	17	10428570	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	13140	10428570	70766640	827	7627											
MYH2	4620	broad.mit.edu	37	chr17	10441071	10441071	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttcttgtactcctcctgctCcagcacgaacatgtggtggt	6	13	9	13	1	1	0	0	0	1	0	4	1	4	0	3	2	4	3	3	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:10441071C>G	uc010coi.2	-	15	1626	c.1498G>C	c.(1498-1500)GAG>CAG	p.E500Q	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E500Q|MYH2_uc010coj.2_Missense_Mutation_p.E500Q	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	500	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCCTCCTGCTCCAGCACGAAC	0.483													82	196					0	0	0	0	G	10441071	G	G	10441071	3	3	36	1	0	0	0	0	1	0	0	0	10088	864	30	2	4431	2	MYH2	17	10441071	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	12501	10441071	70754139	828	7628											
DNAH9	1770	broad.mit.edu	37	chr17	11631206	11631206	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgatgagtttaatcgaatCtccgtggaggtcttgtcagt	8	16	11	6	2	3	2	1	2	2	0	5	4	3	3	1	2	0	1	1	2	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:11631206C>T	uc002gne.2	+	28	5849	c.5781C>T	c.(5779-5781)ATC>ATT	p.I1927I	DNAH9_uc010coo.2_Silent_p.I1221I	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1927	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTAATCGAATCTCCGTGGAGG	0.478													23	69					0	0	0	0	T	11631206	T	T	11631206	2	4	36	1	0	0	0	0	0	0	0	1	4630	903	32	2		2	DNAH9	17	11631206	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1190135	11631206	69564004	829	7629											
DNAH9	1770	broad.mit.edu	37	chr17	11835355	11835355	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctctggagatgtgttctcggGagacggagtttaagagcatc	9	11	14	7	2	2	3	0	0	2	3	4	6	2	4	0	3	1	3	0	3	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:11835355G>T	uc002gne.2	+	64	12198	c.12130G>T	c.(12130-12132)GAG>TAG	p.E4044*	DNAH9_uc010coo.2_Nonsense_Mutation_p.E3262*|DNAH9_uc002gnf.2_Nonsense_Mutation_p.E356*	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	4044	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTGTTCTCGGGAGACGGAGTT	0.498													119	385					1.74062e-63	1.89211e-63	1	0	T	11835355	T	T	11835355	4	4	36	1	0	0	0	0	0	1	0	0	4630	1175	41	2	12384	2	DNAH9	17	11835355	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	204149	11835355	69359855	830	7630											
MYOCD	93649	broad.mit.edu	37	chr17	12666707	12666707	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagacctcttcaatgcacatGagatcttgccaggccccctc	10	9	7	15	0	3	2	1	1	2	2	4	3	3	2	4	1	2	1	4	1	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:12666707G>A	uc002gnn.2	+	13	2862	c.2563G>A	c.(2563-2565)GAG>AAG	p.E855K	MYOCD_uc002gno.2_Missense_Mutation_p.E903K|MYOCD_uc002gnq.2_Missense_Mutation_p.E579K	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	855					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CAATGCACATGAGATCTTGCC	0.498													23	66					0	0	0	0	A	12666707	A	A	12666707	3	1	36	1	0	0	0	0	1	0	0	0	10140	1291	45	2	2773	2	MYOCD	17	12666707	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	831352	12666707	68528503	831	7631											
MPRIP	23164	broad.mit.edu	37	chr17	17062051	17062051	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaggcgggaggagcgccgcaAgcgcttcgggatgctcgacg	7	4	19	11	7	0	0	0	0	0	0	2	5	0	3	1	4	3	3	1	4	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:17062051A>T	uc002gqu.1	+	14	1837	c.1781A>T	c.(1780-1782)AAG>ATG	p.K594M	MPRIP_uc002gqv.1_Missense_Mutation_p.K594M|MPRIP_uc002gqw.1_Missense_Mutation_p.K349M	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	594	Interaction with RHOA.					cytoplasm|cytoskeleton	actin binding				0						GAGCGCCGCAAGCGCTTCGGG	0.731													18	41					0	0	0	0	T	17062051	T	T	17062051	3	4	36	1	0	0	0	0	1	0	0	0	9796	72	3	5	1835	5	MPRIP	17	17062051	Missense_Mutation	SNP	A	TCGA-CN-4723-01A-01D-1434-08	4395344	17062051	64133159	832	7632											
MYO15A	51168	broad.mit.edu	37	chr17	18077224	18077224	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccagcgcaccttgcagctgCagctggagcaggtgggccca	7	5	14	15	1	0	0	0	0	0	0	0	1	0	1	3	3	6	6	3	3	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:18077224C>A	uc010vxh.1	+	64	10818	c.10480C>A	c.(10480-10482)CAG>AAG	p.Q3494K	MYO15A_uc010vxi.1_Missense_Mutation_p.Q758K|MYO15A_uc002gsl.2_Missense_Mutation_p.A526E|MYO15A_uc010vxm.1_Intron|MYO15A_uc010cpv.2_Intron	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3494	Tail.|FERM.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CTTGCAGCTGCAGCTGGAGCA	0.662													17	35					9.7654e-05	0.000100024	1	0	A	18077224	A	A	18077224	3	1	36	1	0	0	0	0	1	0	0	0	10116	711	25	4	10730	4	MYO15A	17	18077224	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1015173	18077224	63117986	833	7633											
LGALS9C	654346	broad.mit.edu	37	chr17	18396112	18396112	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacccagatcaacaactcttGggggtctgaggagcgaagtc	11	7	12	11	1	3	2	1	1	2	1	4	4	3	3	1	3	3	0	1	3	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:18396112G>T	uc002gtw.2	+	10	933	c.863G>T	c.(862-864)TGG>TTG	p.W288L	LGALS9C_uc010vyb.1_Missense_Mutation_p.W200L	NM_001040078	NP_001035167	Q6DKI2	LEG9C_HUMAN	galectin 9 like	288	Galectin 2.|Beta-galactoside binding 2 (By similarity).						sugar binding			ovary(1)	1						AACAACTCTTGGGGGTCTGAG	0.572													3	63					0.00010058	0.000102935	1	0	T	18396112	T	T	18396112	3	4	36	1	0	0	0	0	1	0	0	0	8791	1357	47	4	901	4	LGALS9C	17	18396112	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	318888	18396112	62799098	834	7634											
SLC47A1	55244	broad.mit.edu	37	chr17	19470501	19470501	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatgtggttggcctccccatCgggatcgcgctgatgtttgc	4	13	13	11	3	0	1	0	1	0	0	3	2	1	2	3	3	1	3	3	3	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:19470501C>T	uc002gvy.1	+	14	1355	c.1269C>T	c.(1267-1269)ATC>ATT	p.I423I	SLC47A1_uc002gvx.2_Silent_p.I423I|SLC47A1_uc010vyz.1_Silent_p.I400I|SLC47A1_uc010cqp.1_Intron|SLC47A1_uc010cqq.1_Silent_p.I228I|SLC47A1_uc010vza.1_Silent_p.I135I|SLC47A1_uc010vzb.1_Silent_p.I157I|SLC47A1_uc010vzc.1_Silent_p.I95I	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	423	Helical; (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					GCCTCCCCATCGGGATCGCGC	0.557													90	198					0	0	0	0	T	19470501	T	T	19470501	2	4	36	1	0	0	0	0	0	0	0	1	14711	874	31	1		1	SLC47A1	17	19470501	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1074389	19470501	61724709	835	7635											
LGALS9B	284194	broad.mit.edu	37	chr17	20354855	20354855	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttcgctcctcagaccccCaagagttgttgatctgggtg	7	11	11	12	1	2	3	1	1	1	2	4	4	3	3	3	1	0	3	3	1	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:20354855C>A	uc002gxa.1	-	10	928	c.863G>T	c.(862-864)TGG>TTG	p.W288L	LGALS9B_uc002gwz.1_Missense_Mutation_p.W287L|LGALS9B_uc010vzh.1_Missense_Mutation_p.W200L	NM_001042685	NP_001036150	Q3B8N2	LEG9B_HUMAN	galectin-9 like	288	Galectin 2.|Beta-galactoside binding 2 (By similarity).						sugar binding			skin(1)	1						CTCAGACCCCCAAGAGTTGTT	0.572													20	53					4.3181e-19	4.58798e-19	1	0	A	20354855	A	A	20354855	3	1	36	1	0	0	0	0	1	0	0	0	8790	595	21	4	215	4	LGALS9B	17	20354855	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	884354	20354855	60840355	836	7636											
KCNJ12	3768	broad.mit.edu	37	chr17	21319636	21319636	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctgtggggtcaccgctttGagcccgtgctcttcgaggag	4	11	14	12	3	2	1	1	1	1	0	4	3	3	2	3	3	2	2	3	3	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:21319636G>C	uc002gyv.1	+	3	1687	c.982G>C	c.(982-984)GAG>CAG	p.E328Q		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	328	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TCACCGCTTTGAGCCCGTGCT	0.592										Prostate(3;0.18)			23	188					0	0	0	0	C	21319636	C	C	21319636	3	2	36	1	0	0	0	0	1	0	0	0	8085	1291	45	2	984	2	KCNJ12	17	21319636	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	964781	21319636	59875574	837	7637											
NOS2	4843	broad.mit.edu	37	chr17	26114705	26114705	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcaggaggcaagccttactCtttgaaggagccgtaatatt	11	11	11	8	1	1	1	0	1	1	0	1	3	1	3	2	3	4	3	2	3	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:26114705C>G	uc002gzu.2	-	5	730	c.466G>C	c.(466-468)GAG>CAG	p.E156Q	NOS2_uc010crh.1_Missense_Mutation_p.E156Q|NOS2_uc010wab.1_Missense_Mutation_p.E156Q	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	156					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AAGCCTTACTCTTTGAAGGAG	0.517													47	118					0	0	0	0	G	26114705	G	G	26114705	3	3	36	1	0	0	0	0	1	0	0	0	10597	927	32	2	3087	2	NOS2	17	26114705	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4795069	26114705	55080505	838	7638											
SUPT6H	6830	broad.mit.edu	37	chr17	27001330	27001330	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaggaggagaacctagatGatcaggatgagcaaggcaac	16	4	15	6	0	1	4	1	2	0	2	1	8	1	7	1	5	3	2	1	5	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:27001330G>T	uc002hby.2	+	3	229	c.139G>T	c.(139-141)GAT>TAT	p.D47Y	SUPT6H_uc010crt.2_Missense_Mutation_p.D47Y	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	47	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					GAACCTAGATGATCAGGATGA	0.468													17	53					1.37285e-15	1.4486e-15	1	0	T	27001330	T	T	27001330	3	4	36	1	0	0	0	0	1	0	0	0	15466	1290	45	2	145	2	SUPT6H	17	27001330	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	886625	27001330	54193880	839	7639											
TAOK1	57551	broad.mit.edu	37	chr17	27809270	27809270	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacaatatgatggcaaagtaGatgtgtggtctcttggaata	13	12	12	4	0	1	2	0	1	1	1	2	4	1	3	0	3	0	2	0	3	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:27809270G>C	uc002hdz.1	+	8	813	c.619G>C	c.(619-621)GAT>CAT	p.D207H	TAOK1_uc010wbe.1_Missense_Mutation_p.D207H|TAOK1_uc010wbf.1_Missense_Mutation_p.D207H|TAOK1_uc002heb.1_Missense_Mutation_p.D33H	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	207	Protein kinase.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			TGGCAAAGTAGATGTGTGGTC	0.308													7	183					0	0	0	0	C	27809270	C	C	27809270	3	2	36	1	0	0	0	0	1	0	0	0	15613	942	33	2	645	2	TAOK1	17	27809270	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	807940	27809270	53385940	840	7640											
TMEM132E	124842	broad.mit.edu	37	chr17	32962027	32962027	+	Frame_Shift_Del	DEL	G	-	-																															cctagtcagtgacttcatgcGggtgggcgatccccgagtgg																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:32962027delG	uc002hif.2	+	8	1956	c.1628delG	c.(1627-1629)CGGfs	p.R543fs		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	543	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GACTTCATGCGGGTGGGCGAT	0.617													---	---	---								-	32962027	-	-	32962027	7	5	36	1	0	1	0	1	0	0	0	0	16114	1116	39	0	1658	0	TMEM132E	17	32962027	Frame_Shift_Del	DEL	G	TCGA-CN-4723-01A-01D-1434-08	5152757	32962027	48233183	841	7641											
CCT6B	10693	broad.mit.edu	37	chr17	33266221	33266221	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatcttcaatggcatttttGatagcacgaagtccatctct	10	14	6	11	1	3	1	1	1	2	0	5	2	4	1	2	1	1	2	2	1	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:33266221G>C	uc002hig.2	-	10	1288	c.1194C>G	c.(1192-1194)ATC>ATG	p.I398M	CCT6B_uc010ctg.2_Missense_Mutation_p.I361M|CCT6B_uc010wcc.1_Missense_Mutation_p.I353M	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	398					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				TGGCATTTTTGATAGCACGAA	0.303													7	281					0	0	0	0	C	33266221	C	C	33266221	3	2	36	1	0	0	0	0	1	0	0	0	2973	1280	45	2	418	2	CCT6B	17	33266221	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	304194	33266221	47928989	842	7642											
AP2B1	163	broad.mit.edu	37	chr17	33951593	33951593	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attacaaccctaaagatgatCgggaggctcagaggtcagtc	13	8	11	9	1	2	3	2	1	0	2	4	4	2	4	1	3	2	1	1	3	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:33951593C>T	uc002hjr.2	+	6	892	c.703C>T	c.(703-705)CGG>TGG	p.R235W	AP2B1_uc002hjq.2_Missense_Mutation_p.R235W|AP2B1_uc010wci.1_Missense_Mutation_p.R197W|AP2B1_uc002hjs.2_Missense_Mutation_p.R178W|AP2B1_uc002hjt.2_Missense_Mutation_p.R235W|AP2B1_uc010ctv.2_Missense_Mutation_p.R235W|AP2B1_uc010wcj.1_5'UTR	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	235					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TAAAGATGATCGGGAGGCTCA	0.448													28	99					0	0	0	0	T	33951593	T	T	33951593	3	4	36	1	0	0	0	0	1	0	0	0	741	875	31	1	721	1	AP2B1	17	33951593	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	685372	33951593	47243617	843	7643											
TBC1D3B	414059	broad.mit.edu	37	chr17	34499237	34499237	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttccgtatcgatccctgaaGaacatatgcttccttaatgt	10	14	7	10	2	0	2	0	1	0	1	4	3	3	2	3	0	2	3	3	0	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:34499237G>A	uc002hky.2	-	7	624	c.474C>T	c.(472-474)TTC>TTT	p.F158F	uc002hla.1_5'Flank|uc002hlc.2_5'Flank	NM_001001417	NP_001001417	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3B	158	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GATCCCTGAAGAACATATGCT	0.567													45	555					0	0	0	0	A	34499237	A	A	34499237	2	1	36	1	0	0	0	0	0	0	0	1	15686	933	33	2		2	TBC1D3B	17	34499237	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	547644	34499237	46695973	844	7644											
GGNBP2	79893	broad.mit.edu	37	chr17	34942500	34942500	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgatgactcttgtgttcatCactgtgaagacaaagaggat	12	12	11	6	0	3	5	2	3	1	2	3	6	3	6	0	1	0	1	0	1	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:34942500C>T	uc002hnb.2	+	12	1762	c.1513C>T	c.(1513-1515)CAC>TAC	p.H505Y	GGNBP2_uc002hna.2_3'UTR|GGNBP2_uc002hnc.1_Missense_Mutation_p.H334Y	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	505					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		TTGTGTTCATCACTGTGAAGA	0.353													8	218					0	0	0	0	T	34942500	T	T	34942500	3	4	36	1	0	0	0	0	1	0	0	0	6396	826	29	2	1555	2	GGNBP2	17	34942500	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	443263	34942500	46252710	845	7645											
ACACA	31	broad.mit.edu	37	chr17	35600327	35600327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaggactgatgtgatgttgCtagcatactgagccatttcc	10	12	11	8	0	0	4	0	3	0	1	1	5	1	5	2	1	4	3	2	1	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:35600327C>T	uc002hnm.2	-	22	2971	c.2780G>A	c.(2779-2781)AGC>AAC	p.S927N	ACACA_uc002hnk.2_Missense_Mutation_p.S849N|ACACA_uc002hnl.2_Missense_Mutation_p.S869N|ACACA_uc002hnn.2_Missense_Mutation_p.S927N|ACACA_uc002hno.2_Missense_Mutation_p.S964N|ACACA_uc010cuz.2_Missense_Mutation_p.S927N	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	927					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TGTGATGTTGCTAGCATACTG	0.438													88	188					0	0	0	0	T	35600327	T	T	35600327	3	4	36	1	0	0	0	0	1	0	0	0	106	797	28	4	4400	4	ACACA	17	35600327	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	657827	35600327	45594883	846	7646											
HNF1B	6928	broad.mit.edu	37	chr17	36104543	36104543	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgcgcctacctgagcatccgGtccacctccgcccgctgctc	4	8	9	20	4	0	1	0	1	0	0	4	1	3	1	7	1	4	3	7	1	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:36104543G>A	uc002hok.3	-	1	554	c.333C>T	c.(331-333)GAC>GAT	p.D111D	HNF1B_uc010wdi.1_Silent_p.D111D	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	111					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TGAGCATCCGGTCCACCTCCG	0.706									Hereditary_Prostate_Cancer				28	81					0	0	0	0	A	36104543	A	A	36104543	2	1	36	1	0	0	0	0	0	0	0	1	7291	1252	44	4		4	HNF1B	17	36104543	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	504216	36104543	45090667	847	7647											
KRT10	3858	broad.mit.edu	37	chr17	38975820	38975820	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgaatttcattctccagtCggatcttaatatccaggagt	10	16	7	8	1	3	1	1	1	2	0	6	3	4	3	2	2	0	0	2	2	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:38975820C>T	uc002hvi.2	-	6	1348	c.1322G>A	c.(1321-1323)CGA>CAA	p.R441Q	KRT10_uc010cxd.2_RNA|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	441	Rod.|Gly-rich.|Coil 2.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				ATTCTCCAGTCGGATCTTAAT	0.418													61	184					0	0	0	0	T	38975820	T	T	38975820	3	4	36	1	0	0	0	0	1	0	0	0	8487	884	31	1	444	1	KRT10	17	38975820	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2871277	38975820	42219390	848	7648											
KRT33A	3883	broad.mit.edu	37	chr17	39503388	39503388	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactgactcctggtctcattCaggacctggttcaggtccac	7	12	9	13	0	3	1	3	1	1	0	6	2	5	2	3	4	1	1	3	4	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:39503388C>G	uc002hwk.1	-	4	712	c.675G>C	c.(673-675)CTG>CTC	p.L225L		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	225	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				TGGTCTCATTCAGGACCTGGT	0.597													32	75					0	0	0	0	G	39503388	G	G	39503388	2	3	36	1	0	0	0	0	0	0	0	1	8508	813	29	2		2	KRT33A	17	39503388	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	527568	39503388	41691822	849	7649											
HAP1	9001	broad.mit.edu	37	chr17	39881320	39881320	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcgtgaaatcttcccccCgcatgatatccgctgccagc	8	8	9	16	3	1	2	0	2	1	0	3	2	3	2	5	1	2	2	5	1	2	2	rs149550090	byFrequency	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:39881320C>T	uc002hxm.1	-	12	1661	c.1649G>A	c.(1648-1650)CGG>CAG	p.R550Q	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Missense_Mutation_p.R498Q|HAP1_uc002hxo.1_Missense_Mutation_p.R481Q|HAP1_uc002hxp.1_Missense_Mutation_p.R473Q	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	550	Glu-rich.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			ATCTTCCCCCCGCATGATATC	0.607													147	409					0	0	0	0	T	39881320	T	T	39881320	3	4	36	1	0	0	0	0	1	0	0	0	6992	652	23	1	370	1	HAP1	17	39881320	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	377932	39881320	41313890	850	7650											
WNK4	65266	broad.mit.edu	37	chr17	40947774	40947774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacccctcagctcacttcaGagagctcagatacagaggac	13	6	8	14	0	4	3	4	0	0	3	4	5	4	4	2	1	4	2	2	1	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:40947774G>A	uc002ibj.2	+	16	3175	c.3154G>A	c.(3154-3156)GAG>AAG	p.E1052K	WNK4_uc010wgx.1_Missense_Mutation_p.E716K|CCDC56_uc010wgz.1_Silent_p.L162L	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1052					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity	p.P1052S(1)		ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GCTCACTTCAGAGAGCTCAGA	0.587													31	66					0	0	0	0	A	40947774	A	A	40947774	3	1	36	1	0	0	0	0	1	0	0	0	17448	943	33	2	3216	2	WNK4	17	40947774	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1066454	40947774	40247436	851	7651											
WNK4	65266	broad.mit.edu	37	chr17	40948596	40948596	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccggggatgttggcaggatGgtgagggcgggcccaaggga	7	5	22	7	2	0	1	0	1	0	0	0	4	0	4	2	8	0	2	2	8	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:40948596G>A	uc002ibj.2	+	18	3750	c.3729G>A	c.(3727-3729)ATG>ATA	p.M1243I	WNK4_uc010wgx.1_Missense_Mutation_p.M907I|CCDC56_uc010wgz.1_Intron|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1243					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TTGGCAGGATGGTGAGGGCGG	0.607													19	74					0	0	0	0	A	40948596	A	A	40948596	3	1	36	1	0	0	0	0	1	0	0	0	17448	1362	47	4	3799	4	WNK4	17	40948596	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	822	40948596	40246614	852	7652											
CDC27	996	broad.mit.edu	37	chr17	45214545	45214545	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tataatgtctaggattgactCtgatagcatttcgaaaacaa	15	13	7	6	1	2	2	0	2	2	0	3	4	2	3	0	1	2	1	0	1	7	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:45214545C>T	uc002ild.3	-	14	2013	c.1886G>A	c.(1885-1887)AGA>AAA	p.R629K	CDC27_uc002ile.3_Missense_Mutation_p.R635K|CDC27_uc002ilf.3_Missense_Mutation_p.R628K|CDC27_uc010wkp.1_Missense_Mutation_p.R568K|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	629	TPR 5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						AGGATTGACTCTGATAGCATT	0.348													11	50					0	0	0	0	T	45214545	T	T	45214545	3	4	36	1	0	0	0	0	1	0	0	0	3081	913	32	2	612	2	CDC27	17	45214545	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4265949	45214545	35980665	853	7653											
CDC27	996	broad.mit.edu	37	chr17	45216151	45216151	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaagtcttttgacagaactGaaagagcaacatctttttga	14	14	7	6	0	2	5	0	3	2	2	2	5	2	5	0	0	3	1	0	0	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:45216151G>A	uc002ild.3	-	13	1785	c.1658C>T	c.(1657-1659)TCA>TTA	p.S553L	CDC27_uc002ile.3_Missense_Mutation_p.S559L|CDC27_uc002ilf.3_Missense_Mutation_p.S552L|CDC27_uc010wkp.1_Missense_Mutation_p.S492L|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	553					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						TGACAGAACTGAAAGAGCAAC	0.353													30	118					0	0	0	0	A	45216151	A	A	45216151	3	1	36	1	0	0	0	0	1	0	0	0	3081	1294	45	2	844	2	CDC27	17	45216151	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1606	45216151	35979059	854	7654											
KPNB1	3837	broad.mit.edu	37	chr17	45757436	45757436	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatttattctgtctttcattGaccacattgctggagatgag	10	16	8	7	0	3	3	1	2	2	1	3	4	3	3	1	1	1	1	1	1	2	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:45757436G>C	uc002ilt.1	+	20	2740	c.2404G>C	c.(2404-2406)GAC>CAC	p.D802H	KPNB1_uc010wkw.1_Missense_Mutation_p.D657H|KPNB1_uc010wkx.1_Missense_Mutation_p.D586H	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	802					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						GTCTTTCATTGACCACATTGC	0.363													68	183					0	0	0	0	C	45757436	C	C	45757436	3	2	36	1	0	0	0	0	1	0	0	0	8474	1290	45	2	2482	2	KPNB1	17	45757436	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	541285	45757436	35437774	855	7655											
TBKBP1	9755	broad.mit.edu	37	chr17	45787869	45787869	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctctctcgacagttgctGatggagacggtgggctccga	6	11	13	11	3	2	2	0	1	2	1	5	5	3	2	1	3	1	3	1	3	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:45787869G>C	uc002ilu.2	+	9	2574	c.1725G>C	c.(1723-1725)CTG>CTC	p.L575L		NM_014726	NP_055541	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	575					innate immune response						0						GACAGTTGCTGATGGAGACGG	0.632													17	52					0	0	0	0	C	45787869	C	C	45787869	2	2	36	1	0	0	0	0	0	0	0	1	15704	1277	45	2		2	TBKBP1	17	45787869	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	30433	45787869	35407341	856	7656											
DLX4	1748	broad.mit.edu	37	chr17	48050615	48050615	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccagctggcagcgcagctCggcctcacccagacccaggt	7	4	12	18	2	1	1	1	0	0	1	2	1	1	1	4	3	3	4	4	3	0	0	rs150742579	byFrequency	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:48050615C>T	uc002ipv.2	+	2	733	c.462C>T	c.(460-462)CTC>CTT	p.L154L	DLX4_uc002ipw.2_Silent_p.L82L	NM_138281	NP_612138	Q92988	DLX4_HUMAN	distal-less homeobox 4 isoform a	154	Homeobox.				multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CAGCGCAGCTCGGCCTCACCC	0.642													16	33					0	0	0	0	T	48050615	T	T	48050615	2	4	36	1	0	0	0	0	0	0	0	1	4595	871	31	1		1	DLX4	17	48050615	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2262746	48050615	33144595	857	7657											
COL1A1	1277	broad.mit.edu	37	chr17	48267430	48267430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgcctttagcaccagcatCaccaggttcgcctttagcac	9	10	7	15	2	1	0	1	0	0	0	3	0	1	0	4	1	3	4	4	1	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:48267430C>T	uc002iqm.2	-	36	2617	c.2491G>A	c.(2491-2493)GAT>AAT	p.D831N		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	831	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	GCACCAGCATCACCAGGTTCG	0.662			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						33	100					0	0	0	0	T	48267430	T	T	48267430	3	4	36	1	0	0	0	0	1	0	0	0	3692	826	29	2	1967	2	COL1A1	17	48267430	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	216815	48267430	32927780	858	7658											
ACSF2	80221	broad.mit.edu	37	chr17	48551078	48551082	+	Frame_Shift_Del	DEL	AAGGA	-	-																															gcaagatcgtgggccgctctAaggatatgatcatccggggt																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:48551078_48551082delAAGGA	uc002iqu.2	+	13	1632_1636	c.1528_1532delAAGGA	c.(1528-1533)AAGGATfs	p.K510fs	ACSF2_uc010wml.1_Frame_Shift_Del_p.K467fs|ACSF2_uc010wmm.1_Frame_Shift_Del_p.K535fs|ACSF2_uc010wmn.1_Frame_Shift_Del_p.K497fs|ACSF2_uc010wmo.1_Frame_Shift_Del_p.K350fs|ACSF2_uc010dbt.1_Frame_Shift_Del_p.K14fs	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2 precursor	510_511					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GGGCCGCTCTAAGGATATGATCATC	0.551													---	---	---								-	48551082	-	-	48551078	7	5	36	1	0	1	0	1	0	0	0	0	175	363	13	0	1578	0	ACSF2	17	48551078	Frame_Shift_Del	DEL	AAGGA	TCGA-CN-4723-01A-01D-1434-08	283648	48551078	32644132	859	7659											
CACNA1G	8913	broad.mit.edu	37	chr17	48649387	48649387	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccgatgcttcctacctgaGaatttcagcctgtgagtggt	9	12	10	10	1	1	2	1	2	0	1	2	4	2	2	4	1	4	1	4	1	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:48649387G>A	uc002irk.1	+	5	1107	c.735G>A	c.(733-735)GAG>GAA	p.E245E	CACNA1G_uc002iri.1_Silent_p.E245E|CACNA1G_uc002irj.1_Silent_p.E245E|CACNA1G_uc002irl.1_Silent_p.E245E|CACNA1G_uc002irm.1_Silent_p.E245E|CACNA1G_uc002irn.1_Silent_p.E245E|CACNA1G_uc002iro.1_Silent_p.E245E|CACNA1G_uc002irp.1_Silent_p.E245E|CACNA1G_uc002irq.1_Silent_p.E245E|CACNA1G_uc002irr.1_Silent_p.E245E|CACNA1G_uc002irs.1_Silent_p.E245E|CACNA1G_uc002irt.1_Silent_p.E245E|CACNA1G_uc002irv.1_Silent_p.E245E|CACNA1G_uc002irw.1_Silent_p.E245E|CACNA1G_uc002iru.1_Silent_p.E245E|CACNA1G_uc002irx.1_Silent_p.E158E|CACNA1G_uc002iry.1_Silent_p.E158E|CACNA1G_uc002irz.1_Silent_p.E158E|CACNA1G_uc002isa.1_Silent_p.E158E|CACNA1G_uc002isb.1_Silent_p.E158E|CACNA1G_uc002isc.1_Silent_p.E158E|CACNA1G_uc002isd.1_Silent_p.E158E|CACNA1G_uc002ise.1_Silent_p.E158E|CACNA1G_uc002isf.1_Silent_p.E158E|CACNA1G_uc002isg.1_Silent_p.E158E|CACNA1G_uc002ish.1_Silent_p.E158E|CACNA1G_uc002isi.1_Silent_p.E158E	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	245	Extracellular (Potential).|I.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TCCTACCTGAGAATTTCAGCC	0.597													13	44					0	0	0	0	A	48649387	A	A	48649387	2	1	36	1	0	0	0	0	0	0	0	1	2556	933	33	2		2	CACNA1G	17	48649387	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	98309	48649387	32545823	860	7660											
KIF2B	84643	broad.mit.edu	37	chr17	51901140	51901140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtggttatggtgcatgagtCcaagcaaaaggtggacctca	11	10	13	7	0	1	1	1	1	0	0	2	2	2	2	2	4	2	3	2	4	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:51901140C>T	uc002iua.2	+	1	902	c.746C>T	c.(745-747)TCC>TTC	p.S249F	uc010wna.1_Intron	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	249	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GTGCATGAGTCCAAGCAAAAG	0.537													22	40					0	0	0	0	T	51901140	T	T	51901140	3	4	36	1	0	0	0	0	1	0	0	0	8337	855	30	2	748	2	KIF2B	17	51901140	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3251753	51901140	29294070	861	7661											
HSF5	124535	broad.mit.edu	37	chr17	56540556	56540556	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcaactcatcaactatctGaaagacagcctctaggttta	14	11	6	10	0	4	2	2	1	2	1	4	2	4	2	1	1	4	2	1	1	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:56540556G>A	uc002iwi.1	-	4	1253	c.1129C>T	c.(1129-1131)CAG>TAG	p.Q377*		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	377						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCAACTATCTGAAAGACAGCC	0.443													51	139					0	0	0	0	A	56540556	A	A	56540556	4	1	36	1	0	0	0	0	0	1	0	0	7438	1299	45	2	673	2	HSF5	17	56540556	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4639416	56540556	24654654	862	7662											
MTMR4	9110	broad.mit.edu	37	chr17	56572322	56572322	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcatagtccatggggggctCtgctggaggggcacagcagt	7	8	16	10	0	2	0	1	0	1	0	3	1	3	1	1	6	2	4	1	6	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:56572322C>G	uc002iwj.2	-	16	3291	c.3181G>C	c.(3181-3183)GAG>CAG	p.E1061Q		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	1061						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ATGGGGGGCTCTGCTGGAGGG	0.488													18	69					0	0	0	0	G	56572322	G	G	56572322	3	3	36	1	0	0	0	0	1	0	0	0	9999	922	32	2	422	2	MTMR4	17	56572322	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	31766	56572322	24622888	863	7663											
PPM1E	22843	broad.mit.edu	37	chr17	57058095	57058095	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggttggaaaatgaacagttCaaatccccgggaaacagagt	15	7	12	7	1	1	2	1	1	0	1	2	4	2	4	2	3	2	2	2	3	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:57058095C>G	uc002iwx.2	+	7	2098	c.1971C>G	c.(1969-1971)TTC>TTG	p.F657L	PPM1E_uc010ddd.2_Missense_Mutation_p.F420L	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	666					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			ATGAACAGTTCAAATCCCCGG	0.423													92	283					0	0	0	0	G	57058095	G	G	57058095	3	3	36	1	0	0	0	0	1	0	0	0	12398	825	29	2	1997	2	PPM1E	17	57058095	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	485773	57058095	24137115	864	7664											
GDPD1	284161	broad.mit.edu	37	chr17	57322854	57322854	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagttgtagtgtcacatgatGagaatctaaagagagcaact	16	10	10	5	0	2	3	1	2	1	2	2	5	2	3	0	0	2	3	0	0	6	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:57322854G>C	uc002ixk.1	+	3	402	c.265G>C	c.(265-267)GAG>CAG	p.E89Q	GDPD1_uc002ixj.2_Missense_Mutation_p.E89Q	NM_182569	NP_872375	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain	89	Cytoplasmic (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					GTCACATGATGAGAATCTAAA	0.348													4	127					0	0	0	0	C	57322854	C	C	57322854	3	2	36	1	0	0	0	0	1	0	0	0	6360	1291	45	2	275	2	GDPD1	17	57322854	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	264759	57322854	23872356	865	7665											
MED13	9969	broad.mit.edu	37	chr17	60088194	60088194	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggatctggtgttggcatttGataaaaatgttgactctgag	10	14	13	4	0	2	3	0	3	2	0	2	4	2	4	0	3	0	3	0	3	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:60088194G>A	uc002izo.2	-	9	1761	c.1684C>T	c.(1684-1686)CAA>TAA	p.Q562*	MED13_uc002izp.2_Nonsense_Mutation_p.Q178*	NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	562					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GTTGGCATTTGATAAAAATGT	0.438													46	112					0	0	0	0	A	60088194	A	A	60088194	4	1	36	1	0	0	0	0	0	1	0	0	9483	1299	45	2	4928	2	MED13	17	60088194	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2765340	60088194	21107016	866	7666											
GH1	2688	broad.mit.edu	37	chr17	61994806	61994806	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcgttgtgtgagtttgtgtCgaacttgctgtaggtctgct	5	17	13	6	2	1	1	0	1	1	0	3	2	1	1	0	1	3	5	0	1	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:61994806C>T	uc002jdj.2	-	5	579	c.517G>A	c.(517-519)GAC>AAC	p.D173N	GH1_uc002jdi.2_Missense_Mutation_p.D158N|GH1_uc002jdk.2_Missense_Mutation_p.D133N|GH1_uc002jdl.2_Missense_Mutation_p.D78N|GH1_uc002jdm.2_Missense_Mutation_p.R24Q|GH1_uc002jdn.2_Silent_p.S126S	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	173					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						GAGTTTGTGTCGAACTTGCTG	0.542													49	128					0	0	0	0	T	61994806	T	T	61994806	3	4	36	1	0	0	0	0	1	0	0	0	6404	884	31	1	140	1	GH1	17	61994806	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1906612	61994806	19200404	867	7667											
HELZ	9931	broad.mit.edu	37	chr17	65156472	65156472	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctattagaatgggtgcaaatGagaatcctgctgaaataaat	16	11	9	5	0	0	3	0	2	0	2	1	4	1	3	1	1	2	2	1	1	8	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:65156472G>A	uc010wqk.1	-	17	2272	c.2085C>T	c.(2083-2085)CTC>CTT	p.L695L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.L694L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GGGTGCAAATGAGAATCCTGC	0.358													30	87					0	0	0	0	A	65156472	A	A	65156472	2	1	36	1	0	0	0	0	0	0	0	1	7088	1277	45	2		2	HELZ	17	65156472	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3161666	65156472	16038738	868	7668											
CD300LB	124599	broad.mit.edu	37	chr17	72522048	72522048	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acacacggtcactcttctctCcttgctccgaccctctggtt	5	13	6	17	2	4	0	1	0	3	0	7	1	6	0	3	2	1	2	3	2	0	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:72522048C>G	uc002jkx.2	-	2	333	c.320G>C	c.(319-321)GGA>GCA	p.G107A	CD300LB_uc010wqz.1_Missense_Mutation_p.G107A	NM_174892	NP_777552	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	70	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						ACTCTTCTCTCCTTGCTCCGA	0.532													82	238					0	0	0	0	G	72522048	G	G	72522048	3	3	36	1	0	0	0	0	1	0	0	0	3014	855	30	2	408	2	CD300LB	17	72522048	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	7365576	72522048	8673162	869	7669											
FDXR	2232	broad.mit.edu	37	chr17	72858968	72858968	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggaggcgcagcatctcctGaggatccaccagcttctccc	8	7	10	16	1	2	1	0	1	2	0	5	3	3	3	4	3	2	3	4	3	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:72858968G>C	uc002jly.2	-	12	1534	c.1447C>G	c.(1447-1449)CAG>GAG	p.Q483E	GRIN2C_uc002jlt.1_5'Flank|GRIN2C_uc010wrh.1_5'Flank|GRIN2C_uc002jlu.1_5'Flank|GRIN2C_uc002jlv.1_5'Flank|FDXR_uc010wri.1_Missense_Mutation_p.Q431E|FDXR_uc010wrj.1_Missense_Mutation_p.Q481E|FDXR_uc002jlw.2_Missense_Mutation_p.Q240E|FDXR_uc002jlx.2_Missense_Mutation_p.Q489E|FDXR_uc002jmc.2_Missense_Mutation_p.Q455E|FDXR_uc010wrk.1_Missense_Mutation_p.Q514E|FDXR_uc010wrl.1_Missense_Mutation_p.Q526E|FDXR_uc002jma.2_Missense_Mutation_p.Q484E|FDXR_uc010wrm.1_Missense_Mutation_p.Q443E|FDXR_uc002jlz.2_Missense_Mutation_p.Q475E|FDXR_uc002jmb.2_RNA	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	483					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					AGCATCTCCTGAGGATCCACC	0.687													34	84					0	0	0	0	C	72858968	C	C	72858968	3	2	36	1	0	0	0	0	1	0	0	0	5839	1299	45	2	32	2	FDXR	17	72858968	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	336920	72858968	8336242	870	7670											
CASKIN2	57513	broad.mit.edu	37	chr17	73498777	73498777	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgggaccggcgcttaggtCgaggcgggtctgggggagtg	4	8	22	7	4	1	0	0	0	1	0	2	3	1	2	1	7	0	1	1	7	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:73498777C>T	uc002joc.2	-	18	2928	c.2378G>A	c.(2377-2379)CGA>CAA	p.R793Q	CASKIN2_uc010wsc.1_Missense_Mutation_p.R711Q	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	793	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCGCTTAGGTCGAGGCGGGTC	0.716													5	17					0	0	0	0	T	73498777	T	T	73498777	3	4	36	1	0	0	0	0	1	0	0	0	2679	884	31	1	1242	1	CASKIN2	17	73498777	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	639809	73498777	7696433	871	7671											
TMC6	11322	broad.mit.edu	37	chr17	76121048	76121048	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggcccctccacttccccctCggggtcctgctcttctctct	1	13	7	20	1	3	0	0	0	3	0	8	0	6	0	6	3	1	1	6	3	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:76121048C>T	uc002juj.1	-	6	681	c.555G>A	c.(553-555)CCG>CCA	p.P185P	TMC6_uc002jui.1_5'Flank|TMC6_uc010dhf.1_Silent_p.P18P|TMC6_uc002juk.2_Silent_p.P185P|TMC6_uc010dhg.1_Silent_p.P185P|TMC6_uc002jul.1_Silent_p.P185P|TMC6_uc002jum.3_Silent_p.P18P|TMC6_uc002jun.3_Silent_p.P185P|TMC6_uc002juo.2_Intron|TMC6_uc010wtp.1_Silent_p.P18P	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	185	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			ACTTCCCCCTCGGGGTCCTGC	0.682									Epidermodysplasia_Verruciformis_Familial_Clustering_of				6	6					0	0	0	0	T	76121048	T	T	76121048	2	4	36	1	0	0	0	0	0	0	0	1	16055	871	31	1		1	TMC6	17	76121048	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2622271	76121048	5074162	872	7672											
RNF213	57674	broad.mit.edu	37	chr17	78345702	78345702	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgtaaaagattatattcagGaatatttgaccctgttaaaa	17	14	6	4	0	1	2	1	1	0	1	1	3	1	3	1	1	0	2	1	1	8	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:78345702G>A	uc002jyh.1	+	22	6896	c.6673G>A	c.(6673-6675)GAA>AAA	p.E2225K	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.E607K	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TTATATTCAGGAATATTTGAC	0.348													15	51					0	0	0	0	A	78345702	A	A	78345702	3	1	36	1	0	0	0	0	1	0	0	0	13542	1175	41	2	12955	2	RNF213	17	78345702	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2224654	78345702	2849508	873	7673											
NARF	26502	broad.mit.edu	37	chr17	80442792	80442792	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cggccaaggagctgttcaacGaggatgtggaggaggtcact	10	7	16	8	2	2	0	2	0	0	0	2	5	2	4	1	6	2	2	1	6	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:80442792G>C	uc002kfg.3	+	9	1077	c.937G>C	c.(937-939)GAG>CAG	p.E313Q	NARF_uc002kff.3_Missense_Mutation_p.E254Q|NARF_uc010wvp.1_3'UTR|NARF_uc010dit.2_Missense_Mutation_p.E359Q|NARF_uc002kfj.3_Missense_Mutation_p.E265Q|NARF_uc002kfi.3_RNA|NARF_uc002kfh.3_Missense_Mutation_p.E359Q|NARF_uc002kfk.2_RNA	NM_012336	NP_036468	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor isoform a	313						lamin filament	lamin binding			skin(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			GCTGTTCAACGAGGATGTGGA	0.572													5	63					0	0	0	0	C	80442792	C	C	80442792	3	2	36	1	0	0	0	0	1	0	0	0	10220	1059	37	3	1113	3	NARF	17	80442792	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2097090	80442792	752418	874	7674											
TBCD	6904	broad.mit.edu	37	chr17	80885853	80885853	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cggagccagcctgagctgatCgaggcccatacgtgagtgtc	8	7	14	12	3	0	3	0	3	0	0	2	5	0	4	3	2	4	1	3	2	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr17:80885853C>G	uc002kfz.2	+	30	2812	c.2682C>G	c.(2680-2682)ATC>ATG	p.I894M	TBCD_uc002kfy.1_Missense_Mutation_p.I894M|TBCD_uc002kgb.1_Missense_Mutation_p.I219M|TBCD_uc002kgc.2_Missense_Mutation_p.I39M|TBCD_uc002kgd.2_5'Flank	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	894					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CTGAGCTGATCGAGGCCCATA	0.642													19	50					0	0	0	0	G	80885853	G	G	80885853	3	3	36	1	0	0	0	0	1	0	0	0	15699	874	31	3	2800	3	TBCD	17	80885853	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	443061	80885853	309357	875	7675											
ADCYAP1	116	broad.mit.edu	37	chr18	909481	909481	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcggcgcgggggacgacgcgGagccgctctccaagcgccac	6	2	17	16	8	1	0	0	0	1	0	2	3	1	2	3	4	2	1	3	4	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:909481G>C	uc010dkg.2	+	5	495	c.376G>C	c.(376-378)GAG>CAG	p.E126Q	ADCYAP1_uc010dkh.2_Missense_Mutation_p.E126Q	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	126					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						GGACGACGCGGAGCCGCTCTC	0.667													21	54					0	0	0	0	C	909481	C	C	909481	3	2	36	1	0	0	0	0	1	0	0	0	302	1175	41	2	390	2	ADCYAP1	18	909481	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08		909481	77167767	876	7676											
EPB41L3	23136	broad.mit.edu	37	chr18	5410589	5410589	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggcagtggtctccccgtcGgctgcggtgtccgtgcgctc	1	10	16	14	5	1	0	0	0	1	0	5	0	2	0	3	4	2	3	3	4	0	0	rs140128908		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:5410589G>A	uc002kmt.1	-	14	2183	c.2097C>T	c.(2095-2097)GCC>GCT	p.A699A	EPB41L3_uc010wzh.1_Silent_p.A530A|EPB41L3_uc002kmu.1_Silent_p.A530A|EPB41L3_uc010dkq.1_Silent_p.A421A|EPB41L3_uc002kms.1_5'UTR|EPB41L3_uc010wze.1_5'UTR|EPB41L3_uc010wzf.1_5'UTR|EPB41L3_uc010wzg.1_5'UTR|EPB41L3_uc010dkr.2_Silent_p.A91A	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	699	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TCTCCCCGTCGGCTGCGGTGT	0.532													21	41					0	0	0	0	A	5410589	A	A	5410589	2	1	36	1	0	0	0	0	0	0	0	1	5178	1103	39	1		1	EPB41L3	18	5410589	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4501108	5410589	72666659	877	7677											
PPP4R1	9989	broad.mit.edu	37	chr18	9570206	9570206	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tagattttctatcatttcttCcagttcctttctggtggcca	6	19	6	10	0	4	1	1	0	3	1	6	1	6	1	3	2	0	1	3	2	2	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:9570206C>A	uc002koe.1	-	11	1640	c.1522G>T	c.(1522-1524)GAA>TAA	p.E508*	PPP4R1_uc002kof.2_5'UTR|PPP4R1_uc010wzo.1_Nonsense_Mutation_p.E354*|PPP4R1_uc002kod.1_Nonsense_Mutation_p.E491*|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	508	HEAT 10.				protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						ATCATTTCTTCCAGTTCCTTT	0.428													53	174					1.54043e-34	1.6671e-34	1	0	A	9570206	A	A	9570206	4	1	36	1	0	0	0	0	0	1	0	0	12463	864	30	2	1370	2	PPP4R1	18	9570206	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4159617	9570206	68507042	878	7678											
POTEC	388468	broad.mit.edu	37	chr18	14542978	14542978	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgcccatcttgctcctgagCatcttcataaaggagtcgtc	8	13	8	12	1	3	1	1	1	2	0	6	2	4	2	2	1	3	2	2	1	2	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:14542978C>T	uc010dln.2	-	1	622	c.168G>A	c.(166-168)ATG>ATA	p.M56I	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	56										skin(3)	3						TGCTCCTGAGCATCTTCATAA	0.587													59	621					0	0	0	0	T	14542978	T	T	14542978	3	4	36	1	0	0	0	0	1	0	0	0	12317	710	25	4	1504	4	POTEC	18	14542978	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4972772	14542978	63534270	879	7679											
ROCK1	6093	broad.mit.edu	37	chr18	18629114	18629114	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcttcccagaaaaaagcaGaatcagatctctttatcatt	14	14	4	9	0	4	3	2	0	2	3	6	3	5	3	1	0	1	1	1	0	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:18629114G>A	uc002kte.2	-	4	1294	c.353C>T	c.(352-354)TCT>TTT	p.S118F		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	118	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					GAAAAAAGCAGAATCAGATCT	0.368													29	186					0	0	0	0	A	18629114	A	A	18629114	3	1	36	1	0	0	0	0	1	0	0	0	13582	942	33	2	3831	2	ROCK1	18	18629114	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4086136	18629114	59448134	880	7680											
ESCO1	114799	broad.mit.edu	37	chr18	19153502	19153502	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtccctaaaaacgtactttGagtcactggatgatgcattt	11	14	8	8	1	1	2	1	2	0	0	2	3	2	3	1	1	3	2	1	1	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:19153502G>C	uc002kth.1	-	4	2237	c.1303C>G	c.(1303-1305)CAA>GAA	p.Q435E	ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1	435					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						AACGTACTTTGAGTCACTGGA	0.348													39	159					0	0	0	0	C	19153502	C	C	19153502	3	2	36	1	0	0	0	0	1	0	0	0	5272	1299	45	2	1255	2	ESCO1	18	19153502	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	524388	19153502	58923746	881	7681											
RBBP8	5932	broad.mit.edu	37	chr18	20596847	20596847	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttcggaaaaaagaggagaGaagaaaactgcttgggcaca	17	5	14	5	1	0	3	0	0	0	3	1	6	0	5	0	4	2	3	0	4	6	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:20596847G>C	uc002ktw.2	+	17	2745	c.2414G>C	c.(2413-2415)AGA>ACA	p.R805T	RBBP8_uc002kty.2_Missense_Mutation_p.R805T|RBBP8_uc002ktz.2_Intron|RBBP8_uc002kua.2_Missense_Mutation_p.R810T|RBBP8_uc010xap.1_Missense_Mutation_p.R143T	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	805					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			AAAGAGGAGAGAAGAAAACTG	0.338								Direct_reversal_of_damage|Homologous_recombination					19	102					0	0	0	0	C	20596847	C	C	20596847	3	2	36	1	0	0	0	0	1	0	0	0	13170	942	33	2	2476	2	RBBP8	18	20596847	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1443345	20596847	57480401	882	7682											
HRH4	59340	broad.mit.edu	37	chr18	22048902	22048902	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctatgatcgatacctgtCagtctcaaatgctgtaagtc	11	12	8	10	1	2	1	2	1	1	0	5	2	2	1	1	0	3	3	1	0	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:22048902C>T	uc002kvi.2	+	2	444	c.344C>T	c.(343-345)TCA>TTA	p.S115L	HRH4_uc010xbd.1_Intron|HRH4_uc010dlx.2_Intron	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	115	Cytoplasmic (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	CGATACCTGTCAGTCTCAAAT	0.348													21	116					0	0	0	0	T	22048902	T	T	22048902	3	4	36	1	0	0	0	0	1	0	0	0	7397	838	29	2	350	2	HRH4	18	22048902	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1452055	22048902	56028346	883	7683											
B4GALT6	9331	broad.mit.edu	37	chr18	29211016	29211016	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcaggtagatgatccacatCgtggaagattacacagtccc	12	10	9	10	1	1	3	1	1	0	2	4	4	3	4	2	2	1	1	2	2	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:29211016C>T	uc002kwz.3	-	6	979	c.682G>A	c.(682-684)GAT>AAT	p.D228N	B4GALT6_uc010dma.2_Missense_Mutation_p.D189N|B4GALT6_uc010dmb.2_Missense_Mutation_p.D189N	NM_004775	NP_004766	Q9UBX8	B4GT6_HUMAN	beta-1,4-galactosyltransferase 6	228	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding				0			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			TGATCCACATCGTGGAAGATT	0.433													37	81					0	0	0	0	T	29211016	T	T	29211016	3	4	36	1	0	0	0	0	1	0	0	0	1277	884	31	1	482	1	B4GALT6	18	29211016	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	7162114	29211016	48866232	884	7684											
KIAA1632	57724	broad.mit.edu	37	chr18	43534974	43534974	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaagttcttgggggtttctaCtttagttccaacattgtctc	7	17	9	8	0	3	0	0	0	3	0	5	1	4	0	1	2	2	3	1	2	4	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:43534974C>T	uc002lbm.2	-	2	494	c.394G>A	c.(394-396)GTA>ATA	p.V132I	KIAA1632_uc002lbo.1_Missense_Mutation_p.V132I	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	132					autophagy						0						GGGGTTTCTACTTTAGTTCCA	0.493													46	89					0	0	0	0	T	43534974	T	T	43534974	3	4	36	1	0	0	0	0	1	0	0	0	8288	565	20	4	7517	4	KIAA1632	18	43534974	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	14323958	43534974	34542274	885	7685											
HDHD2	84064	broad.mit.edu	37	chr18	44660911	44660911	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcaactagcagcatgggtCtgacttgtttccgctctagt	8	13	9	11	1	3	1	1	1	2	0	4	1	4	1	1	1	3	4	1	1	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:44660911C>T	uc002lcs.2	-	3	399	c.266G>A	c.(265-267)AGA>AAA	p.R89K	HDHD2_uc002lct.2_5'UTR	NM_032124	NP_115500	Q9H0R4	HDHD2_HUMAN	haloacid dehalogenase-like hydrolase domain	89							hydrolase activity				0						CAGCATGGGTCTGACTTGTTT	0.363													44	76					0	0	0	0	T	44660911	T	T	44660911	3	4	36	1	0	0	0	0	1	0	0	0	7062	913	32	2	533	2	HDHD2	18	44660911	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1125937	44660911	33416337	886	7686											
DYM	54808	broad.mit.edu	37	chr18	46905007	46905007	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctctgacatctgacagatGaacactttcagcaaacagca	14	9	6	12	0	3	4	1	3	2	1	4	4	4	4	1	0	4	2	1	0	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:46905007G>A	uc002ldi.1	-	5	716	c.351C>T	c.(349-351)TTC>TTT	p.F117F	DYM_uc010xdf.1_Intron	NM_017653	NP_060123	Q7RTS9	DYM_HUMAN	dymeclin	117						Golgi apparatus					0						TCTGACAGATGAACACTTTCA	0.323													20	40					0	0	0	0	A	46905007	A	A	46905007	2	1	36	1	0	0	0	0	0	0	0	1	4862	1281	45	2		2	DYM	18	46905007	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2244096	46905007	31172241	887	7687											
CXXC1	30827	broad.mit.edu	37	chr18	47810269	47810269	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccctgcttgctcacctcctCatcctcgcgcacagcctgct	4	10	6	21	2	2	0	2	0	0	0	5	0	4	0	6	0	4	4	6	0	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:47810269C>T	uc002leq.3	-	10	2141	c.1408G>A	c.(1408-1410)GAG>AAG	p.E470K	MBD1_uc002leg.2_5'Flank|MBD1_uc010dow.1_5'Flank|MBD1_uc010xdi.1_5'Flank|MBD1_uc002leh.3_5'Flank|MBD1_uc002len.2_5'Flank|MBD1_uc002lei.3_5'Flank|MBD1_uc002lej.3_5'Flank|MBD1_uc002lek.3_5'Flank|MBD1_uc002lel.3_5'Flank|MBD1_uc002lem.3_5'Flank|MBD1_uc010xdj.1_5'Flank|MBD1_uc010xdk.1_5'Flank|MBD1_uc002leo.2_5'Flank|CXXC1_uc002lep.3_Missense_Mutation_p.E327K|CXXC1_uc002ler.3_Missense_Mutation_p.E474K|CXXC1_uc010doy.2_Missense_Mutation_p.E470K|CXXC1_uc002les.2_Missense_Mutation_p.E470K	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	470	Potential.				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CTCACCTCCTCATCCTCGCGC	0.582													86	159					0	0	0	0	T	47810269	T	T	47810269	3	4	36	1	0	0	0	0	1	0	0	0	4114	835	29	2	586	2	CXXC1	18	47810269	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	905262	47810269	30266979	888	7688											
SMAD4	4089	broad.mit.edu	37	chr18	48575103	48575103	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtgatctatgcccgtctctgGaggtggcctgatcttcacaa	7	12	11	11	1	4	2	1	2	3	0	5	3	4	3	2	3	1	0	2	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:48575103G>C	uc010xdp.1	+	3	835	c.297G>C	c.(295-297)TGG>TGC	p.W99C	SMAD4_uc010xdo.1_RNA	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	99	MH1.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(4)|p.W99R(1)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CCCGTCTCTGGAGGTGGCCTG	0.308									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				37	59					0	0	0	0	C	48575103	C	C	48575103	3	2	36	1	0	0	0	0	1	0	0	0	14824	1183	41	2	303	2	SMAD4	18	48575103	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	764834	48575103	29502145	889	7689											
CPLX4	339302	broad.mit.edu	37	chr18	56964048	56964048	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgtatctgcccaagaataGaatctttatcttcttcctct	9	17	4	11	0	6	2	0	0	6	2	7	2	7	2	2	0	1	1	2	0	6	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:56964048G>C	uc002lhy.2	-	3	552	c.365C>G	c.(364-366)TCT>TGT	p.S122C		NM_181654	NP_857637	Q7Z7G2	CPLX4_HUMAN	complexin 4 precursor	122					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			ovary(1)	1		Colorectal(73;0.175)				CCCAAGAATAGAATCTTTATC	0.428													19	57					0	0	0	0	C	56964048	C	C	56964048	3	2	36	1	0	0	0	0	1	0	0	0	3822	942	33	2	121	2	CPLX4	18	56964048	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	8388945	56964048	21113200	890	7690											
ZNF407	55628	broad.mit.edu	37	chr18	72343890	72343890	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaatgttcactcaaaaccAagaacttctaaatcaatagc	20	9	3	9	0	4	1	3	0	1	1	4	1	4	1	1	0	3	1	1	0	10	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr18:72343890A>G	uc002llw.2	+	1	972	c.915A>G	c.(913-915)CCA>CCG	p.P305P	ZNF407_uc010xfc.1_Silent_p.P305P|ZNF407_uc010dqu.1_Silent_p.P305P|ZNF407_uc002llu.2_Silent_p.P304P	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		ACTCAAAACCAAGAACTTCTA	0.343													46	67					0	0	0	0	G	72343890	G	G	72343890	2	3	36	1	0	0	0	0	0	0	0	1	17954	117	5	5		5	ZNF407	18	72343890	Silent	SNP	A	TCGA-CN-4723-01A-01D-1434-08	15379842	72343890	5733358	891	7691											
C19orf22	91300	broad.mit.edu	37	chr19	900136	900136	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagcactcgcggggtgtataGgcggggtcctctgcaggagt	7	8	17	9	3	1	0	0	0	1	0	3	1	2	1	1	6	2	3	1	6	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:900136G>C	uc002lqg.2	-	5	554	c.486C>G	c.(484-486)GCC>GCG	p.A162A	C19orf22_uc002lqh.2_Silent_p.A141A|C19orf22_uc002lqi.2_Missense_Mutation_p.L162V|C19orf22_uc002lqj.2_Silent_p.A40A	NM_138774	NP_620129	Q96D70	CS022_HUMAN	hypothetical protein LOC91300	162	Arg-rich.					nucleus	nucleic acid binding			pancreas(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGTGTATAGGCGGGGTCCT	0.692													25	42					0	0	0	0	C	900136	C	C	900136	2	2	36	1	0	0	0	0	0	0	0	1	1923	987	35	4		4	C19orf22	19	900136	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08		900136	58228847	892	7692											
HMHA1	23526	broad.mit.edu	37	chr19	1080711	1080711	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaagttcgagcggacgtcatCcagtggtaccatgtcgtcca	9	9	12	11	4	1	0	1	0	0	0	5	3	3	1	3	2	2	2	3	2	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:1080711C>A	uc002lqz.1	+	16	2174	c.1943C>A	c.(1942-1944)TCC>TAC	p.S648Y	HMHA1_uc010xgd.1_Missense_Mutation_p.S664Y|HMHA1_uc010xge.1_Missense_Mutation_p.S516Y|HMHA1_uc002lra.1_Missense_Mutation_p.S488Y|HMHA1_uc002lrb.1_Missense_Mutation_p.S531Y|HMHA1_uc002lrc.1_Missense_Mutation_p.S283Y|HMHA1_uc002lrd.1_5'Flank|HMHA1_uc010dsd.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	648					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGACGTCATCCAGTGGTACC	0.652													18	64					8.28177e-16	8.74624e-16	1	0	A	1080711	A	A	1080711	3	1	36	1	0	0	0	0	1	0	0	0	7279	855	30	2	2005	2	HMHA1	19	1080711	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	180575	1080711	58048272	893	7693											
MIDN	90007	broad.mit.edu	37	chr19	1254429	1254429	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgcatctccctcgcccatCacagccggctccttccggtc	4	9	7	21	3	2	0	1	0	1	0	7	0	4	0	6	2	2	2	6	2	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:1254429C>T	uc002lrp.2	+	5	1163	c.648C>T	c.(646-648)ATC>ATT	p.I216I		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	216						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCGCCCATCACAGCCGGCT	0.711													3	4					0	0	0	0	T	1254429	T	T	1254429	2	4	36	1	0	0	0	0	0	0	0	1	9632	816	29	2		2	MIDN	19	1254429	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	173718	1254429	57874554	894	7694											
C19orf35	374872	broad.mit.edu	37	chr19	2275792	2275792	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccccacctgcggcccgctCtgctaggcgcaggaccagca	6	6	11	18	3	1	0	0	0	1	0	2	1	2	1	5	3	3	4	5	3	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:2275792C>G	uc002lvn.2	-	4	1409	c.1309G>C	c.(1309-1311)GAG>CAG	p.E437Q	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	437										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGCCCGCTCTGCTAGGCGC	0.741													3	5					0	0	0	0	G	2275792	G	G	2275792	3	3	36	1	0	0	0	0	1	0	0	0	1929	922	32	2	116	2	C19orf35	19	2275792	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1021363	2275792	56853191	895	7695											
LMNB2	84823	broad.mit.edu	37	chr19	2438470	2438470	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctcgctccggtggaacaggGactccaggtccttcacacgg	7	7	12	15	3	1	0	1	0	0	0	5	2	4	2	4	5	1	1	4	5	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:2438470G>A	uc002lvy.2	-	3	488	c.401C>T	c.(400-402)TCC>TTC	p.S134F	LMNB2_uc002lwa.1_Missense_Mutation_p.S154F	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	134	Rod.|Coil 1B.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGAACAGGGACTCCAGGTC	0.662													13	26					0	0	0	0	A	2438470	A	A	2438470	3	1	36	1	0	0	0	0	1	0	0	0	8892	1174	41	2	1441	2	LMNB2	19	2438470	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	162678	2438470	56690513	896	7696											
NFIC	4782	broad.mit.edu	37	chr19	3435121	3435121	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gctcgatggaggaagacgtgGacacgagccctggcggcgat	9	5	17	10	5	0	1	0	0	0	1	1	7	0	4	1	5	1	1	1	5	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:3435121G>C	uc010xhi.1	+	6	936	c.874G>C	c.(874-876)GAC>CAC	p.D292H	NFIC_uc002lxo.2_Missense_Mutation_p.D283H|NFIC_uc010xhh.1_Missense_Mutation_p.D283H|NFIC_uc002lxp.2_Missense_Mutation_p.D292H|NFIC_uc010xhj.1_Missense_Mutation_p.D292H|NFIC_uc002lxq.1_Missense_Mutation_p.D244H	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	292					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		GGAAGACGTGGACACGAGCCC	0.662													4	4					0	0	0	0	C	3435121	C	C	3435121	3	2	36	1	0	0	0	0	1	0	0	0	10426	1174	41	2	903	2	NFIC	19	3435121	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	996651	3435121	55693862	897	7697											
TJP3	27134	broad.mit.edu	37	chr19	3734394	3734394	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccaccaccaccccggcatgCtcagcggagccccgaggcca	8	2	10	21	3	1	0	1	0	0	0	1	2	1	1	8	3	3	2	8	3	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:3734394C>T	uc010xhv.1	+	7	1046	c.1046C>T	c.(1045-1047)GCT>GTT	p.A349V	TJP3_uc010xhs.1_Missense_Mutation_p.A316V|TJP3_uc010xht.1_Missense_Mutation_p.A280V|TJP3_uc010xhu.1_Missense_Mutation_p.A325V|TJP3_uc010xhw.1_Missense_Mutation_p.A335V	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	330						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCGGCATGCTCAGCGGAGC	0.637													13	61					0	0	0	0	T	3734394	T	T	3734394	3	4	36	1	0	0	0	0	1	0	0	0	15997	797	28	4	1072	4	TJP3	19	3734394	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	299273	3734394	55394589	898	7698											
EEF2	1938	broad.mit.edu	37	chr19	3982347	3982347	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaacttggccacatacatctCggcaaactgcttcagggtga	11	9	10	11	1	2	1	1	1	1	0	3	2	2	1	1	3	4	2	1	3	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:3982347C>T	uc002lze.2	-	5	771	c.688G>A	c.(688-690)GAG>AAG	p.E230K		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	230						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		ACATACATCTCGGCAAACTGC	0.597													34	87					0	0	0	0	T	3982347	T	T	3982347	3	4	36	1	0	0	0	0	1	0	0	0	4951	893	31	1	1932	1	EEF2	19	3982347	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	247953	3982347	55146636	899	7699											
ZNRF4	148066	broad.mit.edu	37	chr19	5456015	5456015	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gactgcaccttcgacctcaaGgtgctgaacgcccagcgcgc	8	6	11	16	4	1	1	1	1	0	0	2	3	1	1	3	1	4	2	3	1	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:5456015G>A	uc002mca.3	+	1	590	c.513G>A	c.(511-513)AAG>AAA	p.K171K		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	171	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		TCGACCTCAAGGTGCTGAACG	0.667													19	62					0	0	0	0	A	5456015	A	A	5456015	2	1	36	1	0	0	0	0	0	0	0	1	18281	991	35	4		4	ZNRF4	19	5456015	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1473668	5456015	53672968	900	7700											
SLC25A41	284427	broad.mit.edu	37	chr19	6427441	6427441	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgggtgccctctcgctgcaaGatctgcctggcgcagtccag	5	8	13	15	3	2	1	0	0	2	1	4	1	3	1	3	2	3	3	3	2	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:6427441G>A	uc010dus.2	-	5	782	c.696C>T	c.(694-696)ATC>ATT	p.I232I	KHSRP_uc002mer.3_5'Flank|SLC25A41_uc010dut.2_Silent_p.I94I	NM_173637	NP_775908	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	232	Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						CTCGCTGCAAGATCTGCCTGG	0.622													5	12					0	0	0	0	A	6427441	A	A	6427441	2	1	36	1	0	0	0	0	0	0	0	1	14570	932	33	2		2	SLC25A41	19	6427441	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	971426	6427441	52701542	901	7701											
ZNF358	140467	broad.mit.edu	37	chr19	7585641	7585641	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgggcacgacgctggtcccGaccttgtgcccagcccagac	6	6	12	17	3	0	1	0	0	0	1	1	3	1	1	4	2	2	2	4	2	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:7585641G>A	uc002mgn.2	+	2	1683	c.1513G>A	c.(1513-1515)GAC>AAC	p.D505N	MCOLN1_uc010dvh.1_5'Flank|MCOLN1_uc002mgo.2_5'Flank|MCOLN1_uc002mgp.2_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	505					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CGCTGGTCCCGACCTTGTGCC	0.468													33	97					0	0	0	0	A	7585641	A	A	7585641	3	1	36	1	0	0	0	0	1	0	0	0	17934	1058	37	1	1515	1	ZNF358	19	7585641	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1158200	7585641	51543342	902	7702											
MUC16	94025	broad.mit.edu	37	chr19	9057827	9057827	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaatccaggagtcaatgaGaatgttggctctgtcggaat	11	11	12	7	1	2	2	1	2	1	1	4	5	3	4	1	3	0	2	1	3	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:9057827G>C	uc002mkp.2	-	3	29823	c.29619C>G	c.(29617-29619)TTC>TTG	p.F9873L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9875	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGTCAATGAGAATGTTGGCT	0.483													3	164					0	0	0	0	C	9057827	C	C	9057827	3	2	36	1	0	0	0	0	1	0	0	0	10026	933	33	2	14232	2	MUC16	19	9057827	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1472186	9057827	50071156	903	7703											
MUC16	94025	broad.mit.edu	37	chr19	9062946	9062946	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtgagctgagcaaagcctGagatggatgttctgctagag	10	10	14	7	0	1	4	0	3	1	2	1	6	1	5	1	1	4	4	1	1	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:9062946G>C	uc002mkp.2	-	3	24704	c.24500C>G	c.(24499-24501)TCA>TGA	p.S8167*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8169	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCAAAGCCTGAGATGGATGT	0.507													37	89					0	0	0	0	C	9062946	C	C	9062946	4	2	36	1	0	0	0	0	0	1	0	0	10026	1294	45	2	19351	2	MUC16	19	9062946	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	5119	9062946	50066037	904	7704											
MUC16	94025	broad.mit.edu	37	chr19	9065271	9065271	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataaagacagctgggaagatGgagggcttgtttcttccaca	12	10	12	7	0	1	2	0	0	1	2	2	4	2	4	1	3	1	3	1	3	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:9065271G>A	uc002mkp.2	-	3	22379	c.22175C>T	c.(22174-22176)CCA>CTA	p.P7392L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7394	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGGGAAGATGGAGGGCTTGT	0.507													27	52					0	0	0	0	A	9065271	A	A	9065271	3	1	36	1	0	0	0	0	1	0	0	0	10026	1348	47	4	21676	4	MUC16	19	9065271	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2325	9065271	50063712	905	7705											
MUC16	94025	broad.mit.edu	37	chr19	9068706	9068706	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaggtcacagaaacaagaGaggaggtactgtgctcttgc	12	8	13	8	0	2	3	1	1	1	2	2	5	2	4	0	3	4	2	0	3	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:9068706G>C	uc002mkp.2	-	3	18944	c.18740C>G	c.(18739-18741)TCT>TGT	p.S6247C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6249	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGAAACAAGAGAGGAGGTACT	0.483													34	80					0	0	0	0	C	9068706	C	C	9068706	3	2	36	1	0	0	0	0	1	0	0	0	10026	942	33	2	25111	2	MUC16	19	9068706	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3435	9068706	50060277	906	7706											
ZNF560	147741	broad.mit.edu	37	chr19	9578057	9578057	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcagaagaggtaaatggtttCccacatttgtaacacttaaa	15	11	8	7	0	0	2	0	0	0	2	1	2	1	2	1	2	1	4	1	2	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:9578057C>T	uc002mlp.1	-	10	1776	c.1566G>A	c.(1564-1566)GGG>GGA	p.G522G	ZNF560_uc010dwr.1_Silent_p.G416G	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	522	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						TAAATGGTTTCCCACATTTGT	0.398													47	156					0	0	0	0	T	9578057	T	T	9578057	2	4	36	1	0	0	0	0	0	0	0	1	18058	842	30	2		2	ZNF560	19	9578057	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	509351	9578057	49550926	907	7707											
PPAN-P2RY11	692312	broad.mit.edu	37	chr19	10221527	10221527	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atttctgccaggcggtgggcGaggcgcccagtgagggtatg	6	8	18	9	3	1	1	0	1	1	0	1	2	1	1	2	5	1	1	2	5	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:10221527G>A	uc002mna.2	+	11	1186	c.1186G>A	c.(1186-1188)GAG>AAG	p.E396K	PPAN-P2RY11_uc010xla.1_Missense_Mutation_p.E396K|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Missense_Mutation_p.E396K|PPAN_uc002mnb.1_Missense_Mutation_p.E343K	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	396					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GGCGGTGGGCGAGGCGCCCAG	0.612													57	210					0	0	0	0	A	10221527	A	A	10221527	3	1	36	1	0	0	0	0	1	0	0	0	12344	1059	37	1	1228	1	PPAN-P2RY11	19	10221527	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	643470	10221527	48907456	908	7708											
KEAP1	9817	broad.mit.edu	37	chr19	10610625	10610625	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggaggcgtacatcaccgcgtCccctgccccctcagggcact	6	6	11	18	3	2	0	2	0	0	0	3	1	3	1	5	3	2	2	5	3	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:10610625C>G	uc002moq.1	-	2	241	c.85G>C	c.(85-87)GAC>CAC	p.D29H	KEAP1_uc002mor.1_Missense_Mutation_p.D29H	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ATCACCGCGTCCCCTGCCCCC	0.642													38	124					0	0	0	0	G	10610625	G	G	10610625	3	3	36	1	0	0	0	0	1	0	0	0	8180	855	30	2	1809	2	KEAP1	19	10610625	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	389098	10610625	48518358	909	7709											
KRI1	65095	broad.mit.edu	37	chr19	10675660	10675660	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcgggggtccttcttcttCaacaaggagagcgttttgta	8	13	12	8	2	3	1	1	0	2	1	4	2	4	1	1	3	3	2	1	3	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:10675660C>T	uc002moy.1	-	3	246	c.237G>A	c.(235-237)TTG>TTA	p.L79L	KRI1_uc002mox.1_Silent_p.L75L	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	79										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CCTTCTTCTTCAACAAGGAGA	0.458											OREG0025239	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	139					0	0	0	0	T	10675660	T	T	10675660	2	4	36	1	0	0	0	0	0	0	0	1	8483	825	29	2		2	KRI1	19	10675660	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	65035	10675660	48453323	910	7710											
AP1M2	10053	broad.mit.edu	37	chr19	10689577	10689577	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaggcccaccttgaccatGatctccacgcggctgtggga	8	7	11	15	2	1	2	0	2	1	0	2	3	1	3	5	3	0	1	5	3	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:10689577G>A	uc002mpc.2	-	8	963	c.879C>T	c.(877-879)ATC>ATT	p.I293I	AP1M2_uc002mpd.2_Silent_p.I295I	NM_005498	NP_005489	Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	293	MHD.				cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(2)	2			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CCTTGACCATGATCTCCACGC	0.393													6	15					0	0	0	0	A	10689577	A	A	10689577	2	1	36	1	0	0	0	0	0	0	0	1	735	1280	45	2		2	AP1M2	19	10689577	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	13917	10689577	48439406	911	7711											
RGL3	57139	broad.mit.edu	37	chr19	11515837	11515837	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctacctggaaaagaatctCtctgctgctgaggtggttgt	8	13	11	9	0	3	2	0	1	3	1	4	3	3	3	1	3	3	3	1	3	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:11515837C>G	uc002mrp.2	-	9	1235	c.1171G>C	c.(1171-1173)GAG>CAG	p.E391Q	RGL3_uc002mrn.2_Missense_Mutation_p.E155Q|RGL3_uc002mrm.2_Missense_Mutation_p.E155Q|RGL3_uc002mro.2_Missense_Mutation_p.E391Q	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	391	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						AAAAGAATCTCTCTGCTGCTG	0.547													9	261					0	0	0	0	G	11515837	G	G	11515837	3	3	36	1	0	0	0	0	1	0	0	0	13343	922	32	2	1023	2	RGL3	19	11515837	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	826260	11515837	47613146	912	7712											
ZNF490	57474	broad.mit.edu	37	chr19	12721450	12721450	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttgctctggacttgctcctcGaggggtcgctccatctggaa	5	12	12	12	2	2	0	0	0	2	0	6	3	4	2	2	4	2	3	2	4	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:12721450G>C	uc002mtz.2	-	1	174	c.45C>G	c.(43-45)CTC>CTG	p.L15L	ZNF791_uc002mua.2_5'Flank|ZNF791_uc010xml.1_5'Flank|ZNF791_uc010dyu.1_5'Flank|ZNF791_uc010xmm.1_5'Flank	NM_020714	NP_065765	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTGCTCCTCGAGGGGTCGCT	0.567													39	104					0	0	0	0	C	12721450	C	C	12721450	2	2	36	1	0	0	0	0	0	0	0	1	18008	1045	37	3		3	ZNF490	19	12721450	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1205613	12721450	46407533	913	7713											
ZNF791	163049	broad.mit.edu	37	chr19	12734532	12734532	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggactcagtggcttttgagGatgtgtctgtgagcttcagc	7	13	14	7	0	3	2	2	2	1	0	3	4	3	4	0	3	2	2	0	3	0	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:12734532G>A	uc002mua.2	+	2	184	c.22G>A	c.(22-24)GAT>AAT	p.D8N	ZNF791_uc010xml.1_5'UTR|ZNF791_uc010dyu.1_5'UTR|ZNF791_uc010xmm.1_Intron	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	8	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGCTTTTGAGGATGTGTCTGT	0.453													7	248					0	0	0	0	A	12734532	A	A	12734532	3	1	36	1	0	0	0	0	1	0	0	0	18230	1174	41	2	28	2	ZNF791	19	12734532	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	13082	12734532	46394451	914	7714											
RAD23A	5886	broad.mit.edu	37	chr19	13060211	13060211	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctgggccaggagaaccctCagcttttacaggtgtggtcc	8	9	13	11	0	1	1	1	0	0	1	2	2	2	1	3	4	4	2	3	4	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:13060211C>G	uc002mvw.1	+	7	911	c.802C>G	c.(802-804)CAG>GAG	p.Q268E	RAD23A_uc002mvx.1_Missense_Mutation_p.Q267E|RAD23A_uc002mvz.1_Missense_Mutation_p.Q267E|RAD23A_uc002mwa.1_Missense_Mutation_p.Q268E|RAD23A_uc002mvy.1_Missense_Mutation_p.Q102E|RAD23A_uc010xmw.1_Missense_Mutation_p.Q103E	NM_005053	NP_005044	P54725	RD23A_HUMAN	UV excision repair protein RAD23 homolog A	268					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)	1						GGAGAACCCTCAGCTTTTACA	0.612								NER					35	128					0	0	0	0	G	13060211	G	G	13060211	3	3	36	1	0	0	0	0	1	0	0	0	13047	827	29	2	828	2	RAD23A	19	13060211	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	325679	13060211	46068772	915	7715											
WIZ	58525	broad.mit.edu	37	chr19	15547894	15547894	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtcgaagccagccccgcaGaagtcacagcgcatcaggct	10	5	12	14	3	2	1	2	0	0	1	3	2	2	1	3	1	3	3	3	1	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:15547894G>A	uc002nbb.3	-	3	466	c.252C>T	c.(250-252)TTC>TTT	p.F84F		NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						nucleus	zinc ion binding				0						CAGCCCCGCAGAAGTCACAGC	0.647													6	21					0	0	0	0	A	15547894	A	A	15547894	2	1	36	1	0	0	0	0	0	0	0	1	17443	933	33	2		2	WIZ	19	15547894	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2487683	15547894	43581089	916	7716											
C19orf50	79036	broad.mit.edu	37	chr19	18679247	18679247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttcctggaggaagaggatGaagaccccatcccacccagc	11	5	10	15	0	0	3	0	1	0	2	2	6	2	6	6	3	1	0	6	3	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:18679247G>A	uc002njo.2	+	5	479	c.337G>A	c.(337-339)GAA>AAA	p.E113K	C19orf50_uc002njp.2_RNA|C19orf50_uc002njq.2_Missense_Mutation_p.E113K	NM_024069	NP_076974	Q9BQD3	CS050_HUMAN	hypothetical protein LOC79036	113							protein binding				0						GGAAGAGGATGAAGACCCCAT	0.577													106	424					0	0	0	0	A	18679247	A	A	18679247	3	1	36	1	0	0	0	0	1	0	0	0	1941	1291	45	2	351	2	C19orf50	19	18679247	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	3131353	18679247	40449736	917	7717											
ZNF99	7652	broad.mit.edu	37	chr19	22941540	22941540	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagggtttctgtccagtatGaattatctcatgttttctaa	9	18	8	6	0	3	1	1	1	3	0	5	1	4	1	1	1	0	4	1	1	5	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:22941540G>C	uc010xrh.1	-	5	898	c.898C>G	c.(898-900)CAT>GAT	p.H300D		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTCCAGTATGAATTATCTCA	0.353													4	149					0	0	0	0	C	22941540	C	C	22941540	3	2	36	1	0	0	0	0	1	0	0	0	18271	1290	45	2	2226	2	ZNF99	19	22941540	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4262293	22941540	36187443	918	7718											
C19orf12	83636	broad.mit.edu	37	chr19	30193787	30193787	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggcttcgttaaagagcctCtgttgctcggcagggggcag	6	9	16	10	3	1	1	0	0	1	1	3	1	1	1	1	4	2	6	1	4	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:30193787C>G	uc002nsk.2	-	3	689	c.258G>C	c.(256-258)CAG>CAC	p.Q86H	C19orf12_uc002nsj.2_Missense_Mutation_p.Q97H|C19orf12_uc002nsl.2_3'UTR|C19orf12_uc002nsm.2_RNA	NM_031448	NP_113636	Q9NSK7	CS012_HUMAN	hypothetical protein LOC83636 isoform 2	86						integral to membrane					0	Ovarian(5;0.000567)|Breast(6;0.0203)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0435)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.183)			TAAAGAGCCTCTGTTGCTCGG	0.632													6	144					0	0	0	0	G	30193787	G	G	30193787	3	3	36	1	0	0	0	0	1	0	0	0	1918	912	32	2	171	2	C19orf12	19	30193787	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	7252247	30193787	28935196	919	7719											
ZNF536	9745	broad.mit.edu	37	chr19	30936498	30936498	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcggcgtggctcgggcagtGaccaggagtcccagtcggtg	6	6	18	11	4	0	1	0	1	0	0	3	2	1	2	2	5	1	2	2	5	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:30936498G>A	uc002nsu.1	+	2	2167	c.2029G>A	c.(2029-2031)GAC>AAC	p.D677N	ZNF536_uc010edd.1_Missense_Mutation_p.D677N	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	677					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CTCGGGCAGTGACCAGGAGTC	0.706													15	34					0	0	0	0	A	30936498	A	A	30936498	3	1	36	1	0	0	0	0	1	0	0	0	18041	1290	45	2	2031	2	ZNF536	19	30936498	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	742711	30936498	28192485	920	7720											
C19orf40	91442	broad.mit.edu	37	chr19	33467558	33467558	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacaagcagtggcacagcaGatccatgccttcttcacgca	11	7	10	13	1	2	1	1	0	1	1	3	2	3	2	2	2	3	4	2	2	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:33467558G>T	uc002nud.3	+	5	736	c.618G>T	c.(616-618)CAG>CAT	p.Q206H		NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa	206	RuvA domain 2-like.				DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					TGGCACAGCAGATCCATGCCT	0.542								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks			OREG0025408	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	135					6.1207e-33	6.60647e-33	1	0	T	33467558	T	T	33467558	3	4	36	1	0	0	0	0	1	0	0	0	1932	933	33	2	632	2	C19orf40	19	33467558	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2531060	33467558	25661425	921	7721											
LRP3	4037	broad.mit.edu	37	chr19	33696521	33696521	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgggccctcagaccttcactGcacgtggctggtggacacac	7	7	12	15	2	2	1	2	0	0	1	2	2	2	2	2	4	1	2	2	4	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:33696521G>A	uc010edh.2	+	5	938	c.845G>A	c.(844-846)TGC>TAC	p.C282Y	LRP3_uc010xrp.1_Missense_Mutation_p.C156Y|LRP3_uc002nuk.3_Missense_Mutation_p.C156Y	NM_002333	NP_002324	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein	282	Extracellular (Potential).|CUB 2.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			pancreas(2)|ovary(1)	3	Esophageal squamous(110;0.137)					GACCTTCACTGCACGTGGCTG	0.692													9	26					0	0	0	0	A	33696521	A	A	33696521	3	1	36	1	0	0	0	0	1	0	0	0	9008	1319	46	4	863	4	LRP3	19	33696521	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	228963	33696521	25432462	922	7722											
ZNF566	84924	broad.mit.edu	37	chr19	36940594	36940594	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagcaaactgtgagccatgtCtaaaggttttcctatattct	11	15	7	8	0	2	1	0	1	2	0	3	1	3	1	2	1	3	2	2	1	6	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:36940594C>G	uc002oea.3	-	5	624	c.542G>C	c.(541-543)AGA>ACA	p.R181T	ZNF566_uc010xte.1_Missense_Mutation_p.R181T|ZNF566_uc010xtf.1_Missense_Mutation_p.R182T|ZNF566_uc002oeb.3_Missense_Mutation_p.R181T|ZNF566_uc002oec.3_Missense_Mutation_p.R77T|ZNF566_uc010xtg.1_Missense_Mutation_p.R77T	NM_032838	NP_116227	Q969W8	ZN566_HUMAN	zinc finger protein 566 isoform 1	181	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					TGAGCCATGTCTAAAGGTTTT	0.378													51	137					0	0	0	0	G	36940594	G	G	36940594	3	3	36	1	0	0	0	0	1	0	0	0	18064	913	32	2	718	2	ZNF566	19	36940594	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3244073	36940594	22188389	923	7723											
ZNF829	374899	broad.mit.edu	37	chr19	37383092	37383092	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtgtgaatcctctgatgtcGagtaacgagtgagccacgac	11	9	12	9	3	1	3	0	3	1	0	3	6	2	3	2	0	2	1	2	0	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:37383092G>A	uc002ofa.1	-	6	963	c.601C>T	c.(601-603)CGA>TGA	p.R201*	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	201	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTCTGATGTCGAGTAACGAGT	0.373													23	101					0	0	0	0	A	37383092	A	A	37383092	4	1	36	1	0	0	0	0	0	1	0	0	18249	1066	37	1	701	1	ZNF829	19	37383092	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	442498	37383092	21745891	924	7724											
ZNF585A	199704	broad.mit.edu	37	chr19	37643675	37643675	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaggtttctctccagtgtGaattctctgatgaataatca	12	15	7	7	0	3	3	1	3	2	0	6	3	4	3	1	1	0	1	1	1	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:37643675G>T	uc002ofo.1	-	5	1357	c.1126C>A	c.(1126-1128)CAC>AAC	p.H376N	ZNF585A_uc002ofm.1_Missense_Mutation_p.H321N|ZNF585A_uc002ofn.1_Missense_Mutation_p.H321N	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	376	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTCCAGTGTGAATTCTCTGA	0.408													64	134					9.07738e-34	9.80646e-34	1	0	T	37643675	T	T	37643675	3	4	36	1	0	0	0	0	1	0	0	0	18084	1290	45	2	1187	2	ZNF585A	19	37643675	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	260583	37643675	21485308	925	7725											
ZNF607	84775	broad.mit.edu	37	chr19	38189234	38189234	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aataataagatgtgaagcatGactaaaagtttccccacatt	17	11	6	7	0	0	3	0	2	0	1	1	3	1	3	2	0	1	2	2	0	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:38189234G>T	uc002ohc.1	-	5	2394	c.1798C>A	c.(1798-1800)CAT>AAT	p.H600N	ZNF607_uc002ohb.1_Missense_Mutation_p.H599N	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	600	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			TGTGAAGCATGACTAAAAGTT	0.398													23	78					5.45024e-15	5.74599e-15	1	0	T	38189234	T	T	38189234	3	4	36	1	0	0	0	0	1	0	0	0	18100	1290	45	2	296	2	ZNF607	19	38189234	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	545559	38189234	20939749	926	7726											
ZFP36	7538	broad.mit.edu	37	chr19	39897486	39897486	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccggctctcggtgccagcctCagcctgacttcagcgctccc	4	8	10	19	3	3	1	2	1	1	0	5	1	4	1	5	2	4	2	5	2	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:39897486C>T	uc002olh.1	+						ZFP36_uc010egn.1_5'Flank	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog						positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GTGCCAGCCTCAGCCTGACTT	0.522													5	13					0	0	0	0	T	39897486	T	T	39897486	1	4	36	0	1	0	0	0	0	0	0	0	17712	841	29	2		2	ZFP36	19	39897486	5'Flank	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1708252	39897486	19231497	927	7727											
EID2B	126272	broad.mit.edu	37	chr19	40023100	40023100	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aaacagcctgcggcgttcctCgaaatcccgtagtaatctga	11	9	9	12	4	1	1	0	1	1	0	4	2	3	1	3	1	3	3	3	1	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:40023100C>G	uc002olz.1	-	1	395	c.343G>C	c.(343-345)GAG>CAG	p.E115Q		NM_152361	NP_689574	Q96D98	EID2B_HUMAN	EP300 interacting inhibitor of differentiation	115					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGGCGTTCCTCGAAATCCCGT	0.557													34	60					0	0	0	0	G	40023100	G	G	40023100	3	3	36	1	0	0	0	0	1	0	0	0	5010	893	31	3	146	3	EID2B	19	40023100	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	125614	40023100	19105883	928	7728											
FCGBP	8857	broad.mit.edu	37	chr19	40430302	40430302	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactcaccaggacgaagccAacttcaccgcgggtcagcga	11	5	11	14	4	3	0	3	0	0	0	3	3	3	1	3	2	4	1	3	2	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:40430302A>G	uc002omp.3	-	3	1649	c.1641T>C	c.(1639-1641)GTT>GTC	p.V547V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	547	VWFD 1.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGACGAAGCCAACTTCACCGC	0.647													12	31					0	0	0	0	G	40430302	G	G	40430302	2	3	36	1	0	0	0	0	0	0	0	1	5810	117	5	5		5	FCGBP	19	40430302	Silent	SNP	A	TCGA-CN-4723-01A-01D-1434-08	407202	40430302	18698681	929	7729											
MAP3K10	4294	broad.mit.edu	37	chr19	40698342	40698342	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggaccctgagaaggaccCggcagtgacagcggagcagg	10	3	17	11	2	0	2	0	2	0	1	0	6	0	5	2	5	2	3	2	5	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:40698342C>T	uc002ona.2	+	1	692	c.404C>T	c.(403-405)CCG>CTG	p.P135L		NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	135	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						GAGAAGGACCCGGCAGTGACA	0.662													12	67					0	0	0	0	T	40698342	T	T	40698342	3	4	36	1	0	0	0	0	1	0	0	0	9297	652	23	1	406	1	MAP3K10	19	40698342	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	268040	40698342	18430641	930	7730											
SPTBN4	57731	broad.mit.edu	37	chr19	41074133	41074133	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agcggcgtgagcggcgcttgGagcggcaggagtccagcgaa	8	4	19	10	6	0	1	0	1	0	0	1	4	1	3	1	5	4	2	1	5	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:41074133G>C	uc002ony.2	+	31	6987	c.6901G>C	c.(6901-6903)GAG>CAG	p.E2301Q	SPTBN4_uc002onz.2_Missense_Mutation_p.E2301Q|SPTBN4_uc010egx.2_Missense_Mutation_p.E1044Q	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	2301					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCGGCGCTTGGAGCGGCAGGA	0.667													2	9					0	0	0	0	C	41074133	C	C	41074133	3	2	36	1	0	0	0	0	1	0	0	0	15187	1175	41	2	7113	2	SPTBN4	19	41074133	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	375791	41074133	18054850	931	7731											
CCDC97	90324	broad.mit.edu	37	chr19	41825513	41825513	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agtgatgagcagatgcggttCcgggcccccctgctatatga	8	9	13	11	2	0	4	0	3	0	1	1	4	1	4	4	2	3	3	4	2	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:41825513C>G	uc002oqg.2	+	3	659	c.537C>G	c.(535-537)TTC>TTG	p.F179L	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	179											0						AGATGCGGTTCCGGGCCCCCC	0.627													34	158					0	0	0	0	G	41825513	G	G	41825513	3	3	36	1	0	0	0	0	1	0	0	0	2888	854	30	2	547	2	CCDC97	19	41825513	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	751380	41825513	17303470	932	7732											
POU2F2	5452	broad.mit.edu	37	chr19	42600360	42600360	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggggggctgcgggtgcgaGaggtgcgggtcgggcagcgt	3	7	24	7	5	0	1	0	0	0	1	1	2	0	1	0	7	4	2	0	7	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:42600360G>C	uc002osp.2	-	8	604	c.537C>G	c.(535-537)CTC>CTG	p.L179L	POU2F2_uc002osn.2_Intron|POU2F2_uc002oso.2_5'UTR|POU2F2_uc002osq.2_Intron|POU2F2_uc002osr.1_Silent_p.L179L	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	179					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				GCGGGTGCGAGAGGTGCGGGT	0.687													6	29					0	0	0	0	C	42600360	C	C	42600360	2	2	36	1	0	0	0	0	0	0	0	1	12327	957	33	2		2	POU2F2	19	42600360	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	774847	42600360	16528623	933	7733											
PSG8	440533	broad.mit.edu	37	chr19	43268174	43268174	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctgggtgacattctggatCagcagggatgcattggaata	10	11	13	7	0	2	1	1	1	1	0	3	4	3	4	1	4	2	2	1	4	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:43268174C>T	uc002ouo.2	-	2	422	c.324G>A	c.(322-324)CTG>CTA	p.L108L	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Silent_p.L108L|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_5'UTR|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Silent_p.L108L|PSG8_uc002oum.3_Silent_p.L108L|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Silent_p.L108L	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	108	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				CATTCTGGATCAGCAGGGATG	0.418													179	481					0	0	0	0	T	43268174	T	T	43268174	2	4	36	1	0	0	0	0	0	0	0	1	12723	813	29	2		2	PSG8	19	43268174	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	667814	43268174	15860809	934	7734											
PSG5	5673	broad.mit.edu	37	chr19	43689186	43689186	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgtagccagcaagattctGaggcaaattgtggacaagta	14	9	12	6	0	1	2	0	1	1	1	1	4	1	3	1	2	2	4	1	2	5	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:43689186G>C	uc002ovu.2	-	2	309	c.178C>G	c.(178-180)CAG>GAG	p.Q60E	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_5'UTR|PSG5_uc002ovx.2_Missense_Mutation_p.Q60E|PSG5_uc002ovv.2_Missense_Mutation_p.Q60E|PSG5_uc002ovw.2_Missense_Mutation_p.Q60E	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	60	Ig-like V-type.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				GCAAGATTCTGAGGCAAATTG	0.448													105	356					0	0	0	0	C	43689186	C	C	43689186	3	2	36	1	0	0	0	0	1	0	0	0	12720	1299	45	2	845	2	PSG5	19	43689186	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	421012	43689186	15439797	935	7735											
ZNF296	162979	broad.mit.edu	37	chr19	45579002	45579002	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgcggctggggcctctgaaGagctgacagcccagcttctt	6	8	13	14	2	2	3	0	2	2	1	2	3	2	3	3	3	3	3	3	3	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:45579002G>C	uc002pao.2	-	2	474	c.417C>G	c.(415-417)CTC>CTG	p.L139L		NM_145288	NP_660331	Q8WUU4	ZN296_HUMAN	zinc finger protein 296	139					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCCTCTGAAGAGCTGACAGC	0.632													36	106					0	0	0	0	C	45579002	C	C	45579002	2	2	36	1	0	0	0	0	0	0	0	1	17895	929	33	2		2	ZNF296	19	45579002	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1889816	45579002	13549981	936	7736											
DACT3	147906	broad.mit.edu	37	chr19	47151760	47151760	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacactgtagtcatgaccttGagagaacccgaacggaaacg	14	6	10	11	3	1	3	1	2	0	1	1	6	1	4	2	1	3	1	2	1	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:47151760G>C	uc010ekq.2	-	4	1943	c.1869C>G	c.(1867-1869)CTC>CTG	p.L623L		NM_145056	NP_659493	Q96B18	DACT3_HUMAN	thymus expressed gene 3-like	623											0		Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000173)|all cancers(93;0.000464)|Epithelial(262;0.02)|GBM - Glioblastoma multiforme(486;0.0325)		TCATGACCTTGAGAGAACCCG	0.562													108	372					0	0	0	0	C	47151760	C	C	47151760	2	2	36	1	0	0	0	0	0	0	0	1	4240	1277	45	2		2	DACT3	19	47151760	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1572758	47151760	11977223	937	7737											
MEIS3	56917	broad.mit.edu	37	chr19	47912796	47912796	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcatggtctcgaatccaCatattattctagaaaacaag	14	12	5	10	1	3	1	1	0	2	1	6	2	5	1	2	1	1	0	2	1	7	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:47912796C>A	uc002pgu.2	-	7	1053	c.606G>T	c.(604-606)ATG>ATT	p.M202I	MEIS3_uc010xyp.1_5'Flank|MEIS3_uc002pgo.2_Missense_Mutation_p.M1I|MEIS3_uc002pgp.2_Missense_Mutation_p.M34I|MEIS3_uc002pgq.2_Missense_Mutation_p.M283I|MEIS3_uc002pgr.2_Missense_Mutation_p.M70I|MEIS3_uc002pgt.2_Missense_Mutation_p.M185I|MEIS3_uc002pgv.2_Missense_Mutation_p.M185I|MEIS3_uc002pgs.2_Missense_Mutation_p.M202I|MEIS3_uc010eld.2_Missense_Mutation_p.M202I	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	202				M -> I (in Ref. 5).		nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		CTCGAATCCACATATTATTCT	0.373													44	124					2.26627e-22	2.41841e-22	1	0	A	47912796	A	A	47912796	3	1	36	1	0	0	0	0	1	0	0	0	9522	478	17	4	683	4	MEIS3	19	47912796	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	761036	47912796	11216187	938	7738											
SNRNP70	6625	broad.mit.edu	37	chr19	49611111	49611111	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaccgtgagcgggagcgcaGagagcggagccgggagcgag	9	1	22	9	6	0	2	0	1	0	1	0	8	0	6	2	4	5	1	2	4	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:49611111G>A	uc002pmk.2	+	10	1164	c.725G>A	c.(724-726)AGA>AAA	p.R242K	SNRNP70_uc002pmh.1_RNA|SNRNP70_uc002pmi.1_Missense_Mutation_p.R233K|SNRNP70_uc002pml.2_Missense_Mutation_p.E29K|SNRNP70_uc002pmm.2_RNA	NM_003089	NP_003080	P08621	RU17_HUMAN	U1 small nuclear ribonucleoprotein 70 kDa	242	Arg/Glu-rich (mixed charge).				nuclear mRNA splicing, via spliceosome|regulation of RNA splicing	nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						CGGGAGCGCAGAGAGCGGAGC	0.746													4	9					0	0	0	0	A	49611111	A	A	49611111	3	1	36	1	0	0	0	0	1	0	0	0	14922	942	33	2	759	2	SNRNP70	19	49611111	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1698315	49611111	9517872	939	7739											
PNKP	11284	broad.mit.edu	37	chr19	50364730	50364730	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccatacatgaccatgtctGacacggggatatgagaggag	13	7	13	8	1	1	3	0	3	1	1	1	6	1	5	2	3	2	0	2	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:50364730G>A	uc002pqh.2	-	15	1476	c.1424C>T	c.(1423-1425)TCA>TTA	p.S475L	PNKP_uc002pqg.2_Missense_Mutation_p.S256L|PNKP_uc002pqi.2_Missense_Mutation_p.S436L|PNKP_uc002pqj.2_Missense_Mutation_p.S475L|PNKP_uc010enm.2_Missense_Mutation_p.S444L|PNKP_uc002pqk.2_Silent_p.V438V	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	475					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		GACCATGTCTGACACGGGGAT	0.622								Other_BER_factors					27	83					0	0	0	0	A	50364730	A	A	50364730	3	1	36	1	0	0	0	0	1	0	0	0	12202	1294	45	2	149	2	PNKP	19	50364730	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	753619	50364730	8764253	940	7740											
ZNF473	25888	broad.mit.edu	37	chr19	50549104	50549104	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggaatgcgtcaggagtttCagccggccctcacatctgat	9	9	11	12	2	4	1	3	1	1	0	4	3	4	3	2	3	2	1	2	3	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:50549104C>T	uc002prn.2	+	5	1641	c.1404C>T	c.(1402-1404)TTC>TTT	p.F468F	ZNF473_uc002prm.2_Silent_p.F468F|ZNF473_uc010ybo.1_Silent_p.F456F	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	468	Interaction with SLBP/pre-mRNA complex.|C2H2-type 8.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		TCAGGAGTTTCAGCCGGCCCT	0.522													11	38					0	0	0	0	T	50549104	T	T	50549104	2	4	36	1	0	0	0	0	0	0	0	1	17998	825	29	2		2	ZNF473	19	50549104	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	184374	50549104	8579879	941	7741											
LRRC4B	94030	broad.mit.edu	37	chr19	51022334	51022334	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggttgcacatgcccaggttGaggtagcgcaggttgaccag	9	8	15	9	1	0	2	0	2	0	0	0	2	0	2	2	4	3	6	2	4	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:51022334G>A	uc002pss.2	-	3	773	c.636C>T	c.(634-636)CTC>CTT	p.L212L		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	212	Extracellular (Potential).|LRR 6.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		TGCCCAGGTTGAGGTAGCGCA	0.677													14	23					0	0	0	0	A	51022334	A	A	51022334	2	1	36	1	0	0	0	0	0	0	0	1	9057	1277	45	2		2	LRRC4B	19	51022334	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	473230	51022334	8106649	942	7742											
SIGLEC14	100049587	broad.mit.edu	37	chr19	52149128	52149129	+	Frame_Shift_Ins	INS	-	G	G																															gtgccatggtcctcgggcctINSgggggtgagggtgagctccg																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:52149128_52149129insG	uc002pxf.3	-	3	726_727	c.606_607insC	c.(604-609)CCCAGGfs	p.P202fs		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	202_203	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		TCCTCGGGCCTGGGGGTGAGGG	0.634													---	---	---								G	52149129	G	G	52149128	7	5	36	1	0	1	1	0	0	0	0	0	14374	1579	55	0	603	0	SIGLEC14	19	52149128	Frame_Shift_Ins	INS	-	TCGA-CN-4723-01A-01D-1434-08	1126794	52149128	6979855	943	7743											
ZNF836	162962	broad.mit.edu	37	chr19	52659726	52659726	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccactatgaactgtctgatGagttgccaggttggaacttt	9	14	10	8	0	1	3	0	3	1	0	2	4	2	4	2	2	3	2	2	2	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:52659726G>A	uc010ydi.1	-	5	1584	c.1210C>T	c.(1210-1212)CAT>TAT	p.H404Y	ZNF836_uc010ydj.1_Missense_Mutation_p.H404Y	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	404	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTGTCTGATGAGTTGCCAGG	0.403													5	105					0	0	0	0	A	52659726	A	A	52659726	3	1	36	1	0	0	0	0	1	0	0	0	18254	1290	45	2	1602	2	ZNF836	19	52659726	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	510598	52659726	6469257	944	7744											
PPP2R1A	5518	broad.mit.edu	37	chr19	52724383	52724383	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgactacgctcttctgcatCaatgtgagccttccacctgc	8	12	7	14	1	3	2	1	2	2	0	4	2	4	2	3	0	4	2	3	0	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:52724383C>A	uc002pyp.2	+	12	1674	c.1515C>A	c.(1513-1515)ATC>ATA	p.I505I	PPP2R1A_uc010ydk.1_Silent_p.I450I|PPP2R1A_uc002pyq.2_Silent_p.I326I	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	505	PP2A subunit C binding.|HEAT 13.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TCTTCTGCATCAATGTGAGCC	0.597			Mis		clear cell ovarian carcinoma								38	129					4.32679e-17	4.58528e-17	1	0	A	52724383	A	A	52724383	2	1	36	1	0	0	0	0	0	0	0	1	12442	816	29	2		2	PPP2R1A	19	52724383	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	64657	52724383	6404600	945	7745											
ZNF534	147658	broad.mit.edu	37	chr19	52941053	52941053	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaacatggattaactcttCagttacatctgactgaatgg	13	13	7	8	0	4	2	2	2	2	0	4	3	4	3	0	2	3	1	0	2	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:52941053C>T	uc002pzk.2	+	4	440	c.379C>T	c.(379-381)CAG>TAG	p.Q127*	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Nonsense_Mutation_p.Q114*	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTAACTCTTCAGTTACATCT	0.348													19	43					0	0	0	0	T	52941053	T	T	52941053	4	4	36	1	0	0	0	0	0	1	0	0	18040	827	29	2	393	2	ZNF534	19	52941053	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	216670	52941053	6187930	946	7746											
ZNF83	55769	broad.mit.edu	37	chr19	53117232	53117232	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctccggtatgaattctttGatgttgtgcaaggtgtgaaa	9	15	11	6	1	2	3	0	3	2	0	3	3	2	3	1	2	1	3	1	2	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:53117232G>A	uc002pzu.3	-	2	1830	c.586C>T	c.(586-588)CAA>TAA	p.Q196*	ZNF83_uc002pzv.3_Nonsense_Mutation_p.Q196*|ZNF83_uc010eps.2_Nonsense_Mutation_p.Q196*|ZNF83_uc010ept.2_Nonsense_Mutation_p.Q196*|ZNF83_uc010epu.2_Nonsense_Mutation_p.Q196*|ZNF83_uc010epv.2_Nonsense_Mutation_p.Q196*|ZNF83_uc010epw.2_Nonsense_Mutation_p.Q196*|ZNF83_uc010epx.2_Nonsense_Mutation_p.Q196*|ZNF83_uc010epy.2_Nonsense_Mutation_p.Q196*|ZNF83_uc010epz.2_Nonsense_Mutation_p.Q196*|ZNF83_uc010eqb.1_Nonsense_Mutation_p.Q196*	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	196	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		TGAATTCTTTGATGTTGTGCA	0.383													42	141					0	0	0	0	A	53117232	A	A	53117232	4	1	36	1	0	0	0	0	0	1	0	0	18250	1299	45	2	968	2	ZNF83	19	53117232	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	176179	53117232	6011751	947	7747											
ZNF415	55786	broad.mit.edu	37	chr19	53612605	53612605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacttacctgacgtacagtCatgtgtgagccatgattcaa	11	12	9	9	1	2	4	2	4	0	0	2	4	2	4	2	0	3	1	2	0	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:53612605C>T	uc002qax.2	-	7	1186	c.837G>A	c.(835-837)ATG>ATA	p.M279I	ZNF415_uc002qat.2_Missense_Mutation_p.M243I|ZNF415_uc002qaw.2_Missense_Mutation_p.M231I|ZNF415_uc010yds.1_Missense_Mutation_p.M231I|ZNF415_uc010ydt.1_Missense_Mutation_p.M231I|ZNF415_uc002qau.2_Missense_Mutation_p.M218I|ZNF415_uc002qav.2_Missense_Mutation_p.M243I|ZNF415_uc002qba.2_Missense_Mutation_p.M1I|ZNF415_uc002qay.2_Missense_Mutation_p.M218I|ZNF415_uc002qaz.2_Missense_Mutation_p.M279I	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	279	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		GACGTACAGTCATGTGTGAGC	0.403													54	134					0	0	0	0	T	53612605	T	T	53612605	3	4	36	1	0	0	0	0	1	0	0	0	17959	826	29	2	978	2	ZNF415	19	53612605	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	495373	53612605	5516378	948	7748											
ZNF331	55422	broad.mit.edu	37	chr19	54080889	54080889	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaagccgtacaagtgcacaGaatgtgggaaggccttcaat	14	7	12	8	1	1	2	1	0	0	2	1	3	1	3	2	2	3	2	2	2	6	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:54080889G>C	uc002qbx.1	+	7	2509	c.1075G>C	c.(1075-1077)GAA>CAA	p.E359Q	ZNF331_uc002qby.1_Missense_Mutation_p.E359Q|ZNF331_uc002qbz.1_Missense_Mutation_p.E359Q|ZNF331_uc002qca.1_Missense_Mutation_p.E359Q|ZNF331_uc010eqr.1_Missense_Mutation_p.E359Q|ZNF331_uc002qcb.1_Missense_Mutation_p.E359Q|ZNF331_uc002qcc.1_Missense_Mutation_p.E359Q|ZNF331_uc002qcd.1_Missense_Mutation_p.E359Q	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	359	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		CAAGTGCACAGAATGTGGGAA	0.527			T	?	follicular thyroid adenoma								22	64					0	0	0	0	C	54080889	C	C	54080889	3	2	36	1	0	0	0	0	1	0	0	0	17916	943	33	2	1085	2	ZNF331	19	54080889	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	468284	54080889	5048094	949	7749											
KIR3DL1	3811	broad.mit.edu	37	chr19	55340901	55340901	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcttctttctccttcatctCtggtgctccaacaaaaaaag	10	14	4	13	0	5	0	1	0	4	0	8	0	6	0	2	1	2	1	2	1	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:55340901C>G	uc002qhk.3	+	7	1149	c.1086C>G	c.(1084-1086)CTC>CTG	p.L362L	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Silent_p.L287L|KIR3DL1_uc010esf.2_Silent_p.L267L|KIR3DL1_uc010yfo.1_Silent_p.L304L|KIR3DL1_uc002qhl.3_Intron	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	362	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		tccttcatctcTGGTGCTCCA	0.433													52	80					0	0	0	0	G	55340901	G	G	55340901	2	3	36	1	0	0	0	0	0	0	0	1	8359	900	32	2		2	KIR3DL1	19	55340901	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1260012	55340901	3788082	950	7750											
NLRP7	199713	broad.mit.edu	37	chr19	55450851	55450851	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctccgtccaggaacagacGgaggtcggactcctgcaccc	8	6	12	15	3	1	1	0	0	1	1	5	4	3	4	4	4	2	1	4	4	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:55450851G>A	uc002qih.3	-	4	1412	c.1336C>T	c.(1336-1338)CGT>TGT	p.R446C	NLRP7_uc002qig.3_Missense_Mutation_p.R446C|NLRP7_uc002qii.3_Missense_Mutation_p.R446C|NLRP7_uc010esk.2_Missense_Mutation_p.R446C|NLRP7_uc010esl.2_Missense_Mutation_p.R474C	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	446	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AGGAACAGACGGAGGTCGGAC	0.632													21	70					0	0	0	0	A	55450851	A	A	55450851	3	1	36	1	0	0	0	0	1	0	0	0	10536	1116	39	1	1809	1	NLRP7	19	55450851	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	109950	55450851	3678132	951	7751											
SAPS1	22870	broad.mit.edu	37	chr19	55756738	55756738	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctgcagcagcaggtccacGaagtcatccttcttccgaag	9	9	10	13	2	2	0	1	0	1	0	5	2	5	0	3	1	4	4	3	1	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:55756738G>A	uc002qjw.3	-	4	689	c.447C>T	c.(445-447)TTC>TTT	p.F149F	SAPS1_uc002qjv.2_Silent_p.F211F	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	149	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		GCAGGTCCACGAAGTCATCCT	0.647													8	16					0	0	0	0	A	55756738	A	A	55756738	2	1	36	1	0	0	0	0	0	0	0	1	13901	1049	37	1		1	SAPS1	19	55756738	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	305887	55756738	3372245	952	7752											
SUV420H2	84787	broad.mit.edu	37	chr19	55853367	55853367	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacgacctggccaccagcctCgtcctggacccctacctcgg	6	6	10	19	3	0	0	0	0	0	0	3	3	1	1	8	3	2	0	8	3	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:55853367C>T	uc002qkj.3	+	2	311	c.63C>T	c.(61-63)CTC>CTT	p.L21L	SUV420H2_uc010esx.1_Silent_p.L21L|SUV420H2_uc002qkk.1_Silent_p.L21L|SUV420H2_uc002qkl.2_5'UTR	NM_032701	NP_116090	Q86Y97	SV422_HUMAN	suppressor of variegation 4-20 homolog 2	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding				0	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CCACCAGCCTCGTCCTGGACC	0.662													43	108					0	0	0	0	T	55853367	T	T	55853367	2	4	36	1	0	0	0	0	0	0	0	1	15481	871	31	1		1	SUV420H2	19	55853367	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	96629	55853367	3275616	953	7753											
CCDC106	29903	broad.mit.edu	37	chr19	56162717	56162717	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgtggtggggctgggggcGaggcctcggaccctgagtca	4	6	20	11	3	1	1	1	1	0	0	2	3	1	2	3	7	0	1	3	7	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:56162717G>A	uc002qlr.2	+	5	1117	c.382G>A	c.(382-384)GAG>AAG	p.E128K	CCDC106_uc002qls.2_Missense_Mutation_p.E128K|U2AF2_uc002qlt.2_5'Flank|U2AF2_uc002qlu.2_5'Flank	NM_013301	NP_037433	Q9BWC9	CC106_HUMAN	coiled-coil domain containing 106	128						nucleus					0		Colorectal(82;0.00403)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		GGCTGGGGGCGAGGCCTCGGA	0.667													18	30					0	0	0	0	A	56162717	A	A	56162717	3	1	36	1	0	0	0	0	1	0	0	0	2753	1059	37	1	396	1	CCDC106	19	56162717	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	309350	56162717	2966266	954	7754											
NLRP11	204801	broad.mit.edu	37	chr19	56303801	56303801	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaagcactcttccaagggcGctgcagcaattttcagtgag	11	9	11	10	1	2	2	1	1	1	1	3	2	3	2	1	1	3	4	1	1	3	3	rs114762114	by1000genomes	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:56303801G>C	uc010ygf.1	-	9	3090	c.2379C>G	c.(2377-2379)AGC>AGG	p.S793R	NLRP11_uc002qlz.2_Missense_Mutation_p.S640R|NLRP11_uc002qmb.2_Missense_Mutation_p.S694R|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	793							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TTCCAAGGGCGCTGCAGCAAT	0.493													35	101					0	0	0	0	C	56303801	C	C	56303801	3	2	36	1	0	0	0	0	1	0	0	0	10527	1078	38	3	738	3	NLRP11	19	56303801	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	141084	56303801	2825182	955	7755											
NLRP13	126204	broad.mit.edu	37	chr19	56423803	56423803	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgtggagaacaagttggaGaaaaaataggcatacagact	17	7	12	5	0	0	3	0	0	0	3	0	5	0	3	0	3	2	3	0	3	7	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:56423803G>A	uc010ygg.1	-	5	1405	c.1380C>T	c.(1378-1380)TTC>TTT	p.F460F		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	460	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ACAAGTTGGAGAAAAAATAGG	0.507													42	106					0	0	0	0	A	56423803	A	A	56423803	2	1	36	1	0	0	0	0	0	0	0	1	10529	933	33	2		2	NLRP13	19	56423803	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	120002	56423803	2705180	956	7756											
NLRP5	126206	broad.mit.edu	37	chr19	56515156	56515156	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcccccaaaacctgagctCtcagccttgtatcaagatgg	10	11	7	13	0	2	2	2	1	1	1	4	2	3	2	4	1	3	2	4	1	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:56515156C>T	uc002qmj.2	+	2	137	c.137C>T	c.(136-138)TCT>TTT	p.S46F	NLRP5_uc002qmi.2_Missense_Mutation_p.S46F	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	46						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		AACCTGAGCTCTCAGCCTTGT	0.438													48	132					0	0	0	0	T	56515156	T	T	56515156	3	4	36	1	0	0	0	0	1	0	0	0	10534	913	32	2	143	2	NLRP5	19	56515156	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	91353	56515156	2613827	957	7757											
ZNF471	57573	broad.mit.edu	37	chr19	57027752	57027752	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtatgatgttggagaactatCagagcctggtatcacttggt	10	13	12	6	0	2	3	2	1	0	2	2	4	2	3	1	3	2	3	1	3	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:57027752C>G	uc002qnh.2	+	3	275	c.142C>G	c.(142-144)CAG>GAG	p.Q48E		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	48	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		GGAGAACTATCAGAGCCTGGT	0.373													44	147					0	0	0	0	G	57027752	G	G	57027752	3	3	36	1	0	0	0	0	1	0	0	0	17997	827	29	2	148	2	ZNF471	19	57027752	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	512596	57027752	2101231	958	7758											
ZNF471	57573	broad.mit.edu	37	chr19	57037129	57037129	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttactcaacatcaaagaattCatactggagagaaaccctat	17	10	5	9	0	3	2	3	0	0	2	3	4	3	3	1	1	4	0	1	1	7	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:57037129C>T	uc002qnh.2	+	5	1826	c.1693C>T	c.(1693-1695)CAT>TAT	p.H565Y		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	565	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		TCAAAGAATTCATACTGGAGA	0.423													30	86					0	0	0	0	T	57037129	T	T	57037129	3	4	36	1	0	0	0	0	1	0	0	0	17997	826	29	2	1707	2	ZNF471	19	57037129	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	9377	57037129	2091854	959	7759											
ZNF547	284306	broad.mit.edu	37	chr19	57883219	57883219	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggggcatctcgatgaggctCagagattgctgtaccgtgat	8	10	15	8	2	2	3	1	2	1	1	3	5	2	3	1	3	2	4	1	3	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:57883219C>T	uc002qol.2	+	3	287	c.94C>T	c.(94-96)CAG>TAG	p.Q32*	ZNF547_uc010ygx.1_Nonsense_Mutation_p.Q32*	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CGATGAGGCTCAGAGATTGCT	0.512													10	494					0	0	0	0	T	57883219	T	T	57883219	4	4	36	1	0	0	0	0	0	1	0	0	18046	827	29	2	100	2	ZNF547	19	57883219	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	846090	57883219	1245764	960	7760											
ZNF134	7693	broad.mit.edu	37	chr19	58132674	58132674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acaccaaagagttcacactgGagaaaggccatatgagtgca	16	6	10	9	0	1	3	1	1	0	2	1	4	1	3	2	2	1	2	2	2	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:58132674G>A	uc002qpn.2	+	3	1286	c.1187G>A	c.(1186-1188)GGA>GAA	p.G396E	ZNF134_uc002qpo.2_Missense_Mutation_p.G223E|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	396						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		GTTCACACTGGAGAAAGGCCA	0.498													50	168					0	0	0	0	A	58132674	A	A	58132674	3	1	36	1	0	0	0	0	1	0	0	0	17791	1174	41	2	1193	2	ZNF134	19	58132674	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	249455	58132674	996309	961	7761											
ZNF551	90233	broad.mit.edu	37	chr19	58199369	58199369	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccaaagtgctagcctcattCaacaccagagagttcacact	13	8	7	13	0	3	1	3	0	0	1	3	2	3	1	3	0	3	2	3	0	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:58199369C>G	uc002qpw.3	+	3	1901	c.1678C>G	c.(1678-1680)CAA>GAA	p.Q560E	ZNF551_uc002qpv.3_Missense_Mutation_p.Q503E|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	576	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TAGCCTCATTCAACACCAGAG	0.468													42	116					0	0	0	0	G	58199369	G	G	58199369	3	3	36	1	0	0	0	0	1	0	0	0	18050	827	29	2	1688	2	ZNF551	19	58199369	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	66695	58199369	929614	962	7762											
ZNF329	79673	broad.mit.edu	37	chr19	58639517	58639517	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attacactcatagggcttctCaccagtatgagtcctctggt	9	13	8	11	0	3	1	2	1	2	0	5	1	4	1	2	2	1	2	2	2	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr19:58639517C>T	uc002qrn.2	-	4	1591	c.1354G>A	c.(1354-1356)GAG>AAG	p.E452K	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TAGGGCTTCTCACCAGTATGA	0.502													34	87					0	0	0	0	T	58639517	T	T	58639517	3	4	36	1	0	0	0	0	1	0	0	0	17914	835	29	2	275	2	ZNF329	19	58639517	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	440148	58639517	489466	963	7763											
ZNF343	79175	broad.mit.edu	37	chr20	2464518	2464518	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgatgaaggatgacttctcGctaaagcctcgcccacactc	10	9	8	14	2	1	3	0	3	1	0	4	4	1	4	2	1	1	1	2	1	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:2464518G>A	uc002wge.1	-	6	1577	c.1089C>T	c.(1087-1089)AGC>AGT	p.S363S	ZNF343_uc010gao.1_Silent_p.S363S|ZNF343_uc002wgd.1_Silent_p.S273S	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	363	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ATGACTTCTCGCTAAAGCCTC	0.502													14	62					0	0	0	0	A	2464518	A	A	2464518	2	1	36	1	0	0	0	0	0	0	0	1	17925	1078	38	1		1	ZNF343	20	2464518	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08		2464518	60561002	964	7764											
IDH3B	3420	broad.mit.edu	37	chr20	2640908	2640908	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agagatgtggggaggcctcaCctgcatgcagcagttgtcta	9	9	14	9	0	2	1	1	0	1	1	2	3	2	2	2	3	3	4	2	3	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:2640908C>T	uc002wgp.2	-	8	777	c.768_splice	c.e8+1	p.Q256_splice	IDH3B_uc002wgq.2_Splice_Site_p.Q256_splice|IDH3B_uc002wgr.2_Splice_Site_p.Q104_splice	NM_006899	NP_008830	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3, beta subunit isoform						isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	GGAGGCCTCACCTGCATGCAG	0.517													14	48					0	0	0	0	T	2640908	T	T	2640908	5	4	36	1	0	0	0	0	0	0	1	0	7536	521	18	4	493	4	IDH3B	20	2640908	Splice_Site	SNP	C	TCGA-CN-4723-01A-01D-1434-08	176390	2640908	60384612	965	7765											
FASTKD5	60493	broad.mit.edu	37	chr20	3128246	3128246	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctggactgagagcgaaatCaattaactctactggaaagt	14	9	9	9	1	2	1	1	1	1	1	2	5	2	3	1	2	3	0	1	2	5	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:3128246C>T	uc002whz.2	-	2	1782	c.1471G>A	c.(1471-1473)GAT>AAT	p.D491N	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	491					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						AGAGCGAAATCAATTAACTCT	0.468													41	78					0	0	0	0	T	3128246	T	T	3128246	3	4	36	1	0	0	0	0	1	0	0	0	5720	826	29	2	827	2	FASTKD5	20	3128246	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	487338	3128246	59897274	966	7766											
ATRN	8455	broad.mit.edu	37	chr20	3581669	3581669	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacctgggctgccagtttctCaggtaaagacatacctagag	11	9	10	11	0	1	2	1	0	1	2	2	2	1	2	3	2	2	3	3	2	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:3581669C>G	uc002wim.2	+	23	3731	c.3641C>G	c.(3640-3642)TCA>TGA	p.S1214*	ATRN_uc002wil.2_Nonsense_Mutation_p.S1214*	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1214	Extracellular (Potential).				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						GCCAGTTTCTCAGGTAAAGAC	0.333													7	126					0	0	0	0	G	3581669	G	G	3581669	4	3	36	1	0	0	0	0	0	1	0	0	1208	838	29	2	3731	2	ATRN	20	3581669	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	453423	3581669	59443851	967	7767											
LRRN4	164312	broad.mit.edu	37	chr20	6021786	6021786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccgcctgcagagacatgcgGacagcaccacggtgctggcg	8	4	14	15	4	0	1	0	0	0	1	0	3	0	2	3	3	4	3	3	3	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:6021786G>A	uc002wmo.2	-	5	2329	c.2105C>T	c.(2104-2106)TCC>TTC	p.S702F		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	702	Cytoplasmic (Potential).					integral to membrane				skin(3)	3						GAGACATGCGGACAGCACCAC	0.687													9	16					0	0	0	0	A	6021786	A	A	6021786	3	1	36	1	0	0	0	0	1	0	0	0	9087	1174	41	2	121	2	LRRN4	20	6021786	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2440117	6021786	57003734	968	7768											
JAG1	182	broad.mit.edu	37	chr20	10653358	10653358	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagtcactcaccggccaggcGaaactgaaaggcagcacgat	13	5	11	12	3	2	1	2	1	0	0	2	3	2	1	2	3	2	2	2	3	3	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:10653358G>A	uc002wnw.2	-	2	894	c.378C>T	c.(376-378)TTC>TTT	p.F126F		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	126	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						CCGGCCAGGCGAAACTGAAAG	0.652									Alagille_Syndrome				23	49					0	0	0	0	A	10653358	A	A	10653358	2	1	36	1	0	0	0	0	0	0	0	1	7973	1049	37	1		1	JAG1	20	10653358	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4631572	10653358	52372162	969	7769											
CSRP2BP	57325	broad.mit.edu	37	chr20	18162426	18162426	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcgcttggtaggatcagaaGatatggctgtggaccagagt	11	10	14	6	1	1	3	1	0	0	3	2	5	1	5	1	4	0	3	1	4	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:18162426G>C	uc002wqj.2	+	8	2366	c.1744G>C	c.(1744-1746)GAT>CAT	p.D582H	CSRP2BP_uc002wqk.2_Missense_Mutation_p.D454H|CSRP2BP_uc010zru.1_Missense_Mutation_p.D453H	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	582					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						AGGATCAGAAGATATGGCTGT	0.443													57	117					0	0	0	0	C	18162426	C	C	18162426	3	2	36	1	0	0	0	0	1	0	0	0	3985	942	33	2	1770	2	CSRP2BP	20	18162426	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	7509068	18162426	44863094	970	7770											
ZHX3	23051	broad.mit.edu	37	chr20	39832032	39832032	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgacagaagctccctttcaGagctgacagctgttcatgag	10	9	10	12	1	2	4	2	2	0	2	3	5	3	4	2	0	3	4	2	0	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:39832032G>C	uc002xjs.1	-	3	1903	c.1525C>G	c.(1525-1527)CTG>GTG	p.L509V	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.L509V|ZHX3_uc002xjt.1_Missense_Mutation_p.L509V|ZHX3_uc002xju.1_Missense_Mutation_p.L509V|ZHX3_uc002xjv.1_Missense_Mutation_p.L509V|ZHX3_uc002xjw.1_Missense_Mutation_p.L509V|ZHX3_uc010ggg.1_Missense_Mutation_p.L509V	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	509	Required for nuclear localization.|Homeobox 2.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				CTCCCTTTCAGAGCTGACAGC	0.527													18	77					0	0	0	0	C	39832032	C	C	39832032	3	2	36	1	0	0	0	0	1	0	0	0	17744	933	33	2	1353	2	ZHX3	20	39832032	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	21669606	39832032	23193488	971	7771											
SEMG2	6407	broad.mit.edu	37	chr20	43850534	43850534	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaagtcagcaatatgatttGaatgccctacataaggcgac	16	9	8	8	1	1	2	1	2	0	0	1	3	1	2	1	1	3	1	1	1	7	4	rs147702753	byFrequency	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:43850534G>C	uc010ggz.2	+	2	318	c.261G>C	c.(259-261)TTG>TTC	p.L87F	SEMG2_uc002xnk.2_Missense_Mutation_p.L87F|SEMG2_uc002xnl.2_Missense_Mutation_p.L87F	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	87	Repeat-rich region.|3-1.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				AATATGATTTGAATGCCCTAC	0.363													35	90					0	0	0	0	C	43850534	C	C	43850534	3	2	36	1	0	0	0	0	1	0	0	0	14110	1281	45	2	267	2	SEMG2	20	43850534	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4018502	43850534	19174986	972	7772											
ZSWIM1	90204	broad.mit.edu	37	chr20	44512005	44512005	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agccactacttccagagcctCgaggtcaccacccacatcct	10	7	6	18	1	1	1	1	0	0	1	4	2	3	1	6	1	3	0	6	1	1	2	rs116789871	by1000genomes	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:44512005C>G	uc010ghi.2	+	2	887	c.774C>G	c.(772-774)CTC>CTG	p.L258L	ZSWIM1_uc010zxh.1_Silent_p.L131L	NM_080603	NP_542170	Q9BR11	ZSWM1_HUMAN	zinc finger, SWIM-type containing 1	258							zinc ion binding			skin(1)	1		Myeloproliferative disorder(115;0.028)				TCCAGAGCCTCGAGGTCACCA	0.572													3	149					0	0	0	0	G	44512005	G	G	44512005	2	3	36	1	0	0	0	0	0	0	0	1	18307	871	31	3		3	ZSWIM1	20	44512005	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	661471	44512005	18513515	973	7773											
KCNB1	3745	broad.mit.edu	37	chr20	47990509	47990509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catcttattgtacatgtcttCcaactgctgaacgttcaggt	9	15	7	10	1	3	1	1	1	2	0	4	1	4	1	1	1	4	3	1	1	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:47990509C>T	uc002xur.1	-	2	1752	c.1588G>A	c.(1588-1590)GAA>AAA	p.E530K	KCNB1_uc002xus.1_Missense_Mutation_p.E530K	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	530	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TACATGTCTTCCAACTGCTGA	0.468													98	295					0	0	0	0	T	47990509	T	T	47990509	3	4	36	1	0	0	0	0	1	0	0	0	8051	864	30	2	992	2	KCNB1	20	47990509	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3478504	47990509	15035011	974	7774											
B4GALT5	9334	broad.mit.edu	37	chr20	48330154	48330154	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgaagtacagcagcgaggacGagagagaaaagaagaagagc	19	1	15	6	3	0	5	0	0	0	5	0	10	0	6	0	1	4	2	0	1	6	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:48330154G>A	uc002xuu.3	-	1	268	c.74C>T	c.(73-75)TCG>TTG	p.S25L		NM_004776	NP_004767	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	25	Helical; Signal-anchor for type II membrane protein; (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			CAGCGAGGACGAGAGAGAAAA	0.706													3	5					0	0	0	0	A	48330154	A	A	48330154	3	1	36	1	0	0	0	0	1	0	0	0	1276	1059	37	1	1128	1	B4GALT5	20	48330154	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	339645	48330154	14695366	975	7775											
DPM1	8813	broad.mit.edu	37	chr20	49552791	49552791	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atttctctagaacttcttttCggtataatctgtaagaaatt	12	18	5	6	1	3	2	0	0	3	2	5	2	3	2	0	1	1	2	0	1	6	9			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:49552791C>T	uc002xvw.1	-	8	572	c.572G>A	c.(571-573)CGA>CAA	p.R191Q	DPM1_uc002xvv.1_Missense_Mutation_p.R121Q|DPM1_uc002xvx.1_RNA	NM_003859	NP_003850	O60762	DPM1_HUMAN	dolichyl-phosphate mannosyltransferase 1	191				R -> P (in Ref. 6; AAC98797).	C-terminal protein lipidation|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|protein N-linked glycosylation via asparagine|protein O-linked mannosylation	dolichol-phosphate-mannose synthase complex|endoplasmic reticulum membrane|membrane fraction	dolichyl-phosphate beta-D-mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding			ovary(1)	1						AACTTCTTTTCGGTATAATCT	0.318													21	54					0	0	0	0	T	49552791	T	T	49552791	3	4	36	1	0	0	0	0	1	0	0	0	4746	884	31	1	218	1	DPM1	20	49552791	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1222637	49552791	13472729	976	7776											
SLC17A9	63910	broad.mit.edu	37	chr20	61594629	61594629	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accgttgctccctcagatctCatcctggccttgggtgtcct	4	13	9	15	1	2	1	2	0	1	1	6	1	5	1	5	2	1	2	5	2	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:61594629C>T	uc002yea.3	+	6	817	c.633C>T	c.(631-633)CTC>CTT	p.L211L	SLC17A9_uc002ydz.3_Silent_p.L205L|SLC17A9_uc011aap.1_Silent_p.L231L	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	211					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						CCTCAGATCTCATCCTGGCCT	0.622													7	45					0	0	0	0	T	61594629	T	T	61594629	2	4	36	1	0	0	0	0	0	0	0	1	14489	813	29	2		2	SLC17A9	20	61594629	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	12041838	61594629	1430891	977	7777											
GMEB2	26205	broad.mit.edu	37	chr20	62234366	62234366	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacaaacttcctccagatGaggttggctctgctgtctcc	8	11	8	14	0	2	2	0	1	2	1	5	2	4	2	3	2	2	3	3	2	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:62234366G>T	uc002yfp.1	-	3	788	c.309C>A	c.(307-309)CTC>CTA	p.L103L	GMEB2_uc002yfo.1_Silent_p.L25L|GMEB2_uc002yfq.1_Silent_p.L103L	NM_012384	NP_036516	Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding	103	SAND.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding				0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			TCCTCCAGATGAGGTTGGCTC	0.537													7	212					0.00198382	0.00201845	1	0	T	62234366	T	T	62234366	2	4	36	1	0	0	0	0	0	0	0	1	6525	1277	45	2		2	GMEB2	20	62234366	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	639737	62234366	791154	978	7778											
UCKL1	54963	broad.mit.edu	37	chr20	62587639	62587639	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgcacgcggtctcgcttttCtcagcctgccggcctggtgt	2	12	12	15	5	2	0	1	0	2	0	5	0	2	0	3	3	2	2	3	3	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr20:62587639C>G	uc010gkn.2	-	1	130	c.87G>C	c.(85-87)GAG>GAC	p.E29D	UCKL1_uc011abn.1_RNA|UCKL1_uc011abo.1_RNA|UCKL1AS_uc011abp.1_RNA	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	29					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TCTCGCTTTTCTCAGCCTGCC	0.741													4	17					0	0	0	0	G	62587639	G	G	62587639	3	3	36	1	0	0	0	0	1	0	0	0	16993	912	32	2	1619	2	UCKL1	20	62587639	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	353273	62587639	437881	979	7779											
APP	351	broad.mit.edu	37	chr21	27284272	27284272	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctctttctgaagcagctCatctaaaccaaacaaaacca	15	10	4	12	0	4	1	1	1	3	0	4	1	4	1	2	0	6	3	2	0	6	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:27284272C>T	uc002ylz.2	-	14	1890	c.1690G>A	c.(1690-1692)GAG>AAG	p.E564K	APP_uc011acg.1_Missense_Mutation_p.E72K|APP_uc010glk.2_Missense_Mutation_p.E540K|APP_uc002yma.2_Missense_Mutation_p.E545K|APP_uc011ach.1_Missense_Mutation_p.E508K|APP_uc002ymb.2_Missense_Mutation_p.E489K|APP_uc010glj.2_Missense_Mutation_p.E433K|APP_uc011aci.1_Missense_Mutation_p.E454K	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	564	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				TGAAGCAGCTCATCTAAACCA	0.284													16	56					0	0	0	0	T	27284272	T	T	27284272	3	4	36	1	0	0	0	0	1	0	0	0	815	835	29	2	642	2	APP	21	27284272	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08		27284272	20845623	980	7780											
ADAMTS5	11096	broad.mit.edu	37	chr21	28338537	28338537	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagggggtgcgggtggccGggaggctcggctcgctcctg	2	6	21	12	4	0	0	0	0	0	0	3	1	1	1	3	7	1	3	3	7	0	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:28338537G>A	uc002ymg.2	-	1	903	c.174C>T	c.(172-174)CCC>CCT	p.P58P		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	58					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GCGGGTGGCCGGGAGGCTCGG	0.726													6	39					0	0	0	0	A	28338537	A	A	28338537	2	1	36	1	0	0	0	0	0	0	0	1	269	1103	39	1		1	ADAMTS5	21	28338537	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1054265	28338537	19791358	981	7781											
TIAM1	7074	broad.mit.edu	37	chr21	32503217	32503217	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgtcttacaagtttcttCttctgtttggaaccatcttt	8	19	6	8	0	5	1	0	0	5	1	5	2	5	2	1	1	2	2	1	1	3	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:32503217C>G	uc002yow.1	-	25	4405	c.3933G>C	c.(3931-3933)AAG>AAC	p.K1311N	TIAM1_uc011adk.1_Missense_Mutation_p.K1311N|TIAM1_uc011adl.1_Missense_Mutation_p.K1251N	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1311	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						CAAGTTTCTTCTTCTGTTTGG	0.348													18	66					0	0	0	0	G	32503217	G	G	32503217	3	3	36	1	0	0	0	0	1	0	0	0	15956	912	32	2	862	2	TIAM1	21	32503217	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4164680	32503217	15626678	982	7782											
MRAP	56246	broad.mit.edu	37	chr21	33671366	33671366	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacctcattcccgtggacgaGaagaagctgaaagcccacaa	14	5	10	12	2	1	3	1	1	0	2	2	6	2	4	3	1	2	1	3	1	4	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:33671366G>A	uc002ypj.2	+	3	271	c.84G>A	c.(82-84)GAG>GAA	p.E28E	MRAP_uc002ypk.2_Silent_p.E28E|MRAP_uc011ado.1_Intron|MRAP_uc002ypl.2_Silent_p.E28E	NM_178817	NP_848932	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	28	Cytoplasmic (Potential).				positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding				0						CCGTGGACGAGAAGAAGCTGA	0.577													16	26					0	0	0	0	A	33671366	A	A	33671366	2	1	36	1	0	0	0	0	0	0	0	1	9806	933	33	2		2	MRAP	21	33671366	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1168149	33671366	14458529	983	7783											
CLIC6	54102	broad.mit.edu	37	chr21	36079593	36079593	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtaggctggttatgatggtGagagtatcggaaattgcccg	9	12	15	5	2	0	2	0	2	0	1	1	4	0	3	1	4	1	4	1	4	4	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:36079593G>C	uc010gmt.1	+	3	1444	c.1444G>C	c.(1444-1446)GAG>CAG	p.E482Q	CLIC6_uc002yuf.1_Missense_Mutation_p.E464Q	NM_053277	NP_444507	Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	482						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						TTATGATGGTGAGAGTATCGG	0.423													20	78					0	0	0	0	C	36079593	C	C	36079593	3	2	36	1	0	0	0	0	1	0	0	0	3545	1291	45	2	1396	2	CLIC6	21	36079593	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2408227	36079593	12050302	984	7784											
DYRK1A	1859	broad.mit.edu	37	chr21	38884327	38884327	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcatgtagcccctcaacaGaatgcattgcatcatcacca	12	11	5	13	0	4	1	4	0	0	1	4	1	4	1	3	0	4	3	3	0	3	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:38884327G>C	uc002ywk.2	+	11	1860	c.1785G>C	c.(1783-1785)CAG>CAC	p.Q595H	DYRK1A_uc002ywi.2_3'UTR|DYRK1A_uc002ywj.2_Missense_Mutation_p.Q586H|DYRK1A_uc002ywl.2_3'UTR|DYRK1A_uc002ywm.2_3'UTR|DYRK1A_uc011aei.1_Missense_Mutation_p.Q356H	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	595					nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4						CCCCTCAACAGAATGCATTGC	0.388													22	59					0	0	0	0	C	38884327	C	C	38884327	3	2	36	1	0	0	0	0	1	0	0	0	4876	933	33	2	1911	2	DYRK1A	21	38884327	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2804734	38884327	9245568	985	7785											
KCNJ15	3772	broad.mit.edu	37	chr21	39672179	39672179	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatttcagtcagtttgaacaGattcggaaaagcccagattg	13	11	10	7	1	2	3	2	1	0	2	3	5	2	4	1	1	2	1	1	1	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:39672179G>C	uc002ywv.2	+	4	1298	c.996G>C	c.(994-996)CAG>CAC	p.Q332H	KCNJ15_uc002yww.2_Missense_Mutation_p.Q332H|KCNJ15_uc002ywx.2_Missense_Mutation_p.Q332H	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	332	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						AGTTTGAACAGATTCGGAAAA	0.433													31	105					0	0	0	0	C	39672179	C	C	39672179	3	2	36	1	0	0	0	0	1	0	0	0	8088	933	33	2	998	2	KCNJ15	21	39672179	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	787852	39672179	8457716	986	7786											
ETS2	2114	broad.mit.edu	37	chr21	40191474	40191474	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaacggtgcggacagcttcGagagctcagactccctcctc	9	7	11	14	3	1	3	1	0	0	3	5	5	3	4	2	2	4	2	2	2	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:40191474G>A	uc002yxg.2	+	8	1055	c.859G>A	c.(859-861)GAG>AAG	p.E287K	ETS2_uc002yxf.2_Missense_Mutation_p.E427K	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	287					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				GGACAGCTTCGAGAGCTCAGA	0.552													16	54					0	0	0	0	A	40191474	A	A	40191474	3	1	36	1	0	0	0	0	1	0	0	0	5300	1059	37	1	885	1	ETS2	21	40191474	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	519295	40191474	7938421	987	7787											
BRWD1	54014	broad.mit.edu	37	chr21	40574319	40574319	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgatgattctgctgaatctGaagagtcaccagaagtaaca	14	10	9	8	0	3	6	1	4	2	2	3	6	3	6	1	0	2	2	1	0	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:40574319G>C	uc002yxk.1	-	38	4656	c.4517C>G	c.(4516-4518)TCA>TGA	p.S1506*	BRWD1_uc010goc.1_Nonsense_Mutation_p.S149*|BRWD1_uc002yxl.2_Nonsense_Mutation_p.S1506*|BRWD1_uc010god.1_Nonsense_Mutation_p.S424*	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TGCTGAATCTGAAGAGTCACC	0.393													31	85					0	0	0	0	C	40574319	C	C	40574319	4	2	36	1	0	0	0	0	0	1	0	0	1530	1294	45	2	2704	2	BRWD1	21	40574319	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	382845	40574319	7555576	988	7788											
IGSF5	150084	broad.mit.edu	37	chr21	41165472	41165472	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgttgcagacaccgcttctCtccctcccaaatcctgtgaa	8	11	6	16	1	1	2	0	1	1	1	5	2	4	2	4	0	1	3	4	0	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:41165472C>G	uc002yyo.2	+	8	1163	c.1060C>G	c.(1060-1062)CTC>GTC	p.L354V		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	354	Cytoplasmic (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				CACCGCTTCTCTCCCTCCCAA	0.423													31	99					0	0	0	0	G	41165472	G	G	41165472	3	3	36	1	0	0	0	0	1	0	0	0	7641	913	32	2	1090	2	IGSF5	21	41165472	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	591153	41165472	6964423	989	7789											
MX1	4599	broad.mit.edu	37	chr21	42823125	42823125	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgctttcacagatgtttcGataaaaaattttgaagagtt	13	16	7	5	1	1	3	1	1	0	2	2	4	1	3	0	0	1	3	0	0	4	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:42823125G>A	uc002yzh.2	+	17	2411	c.1464G>A	c.(1462-1464)TCG>TCA	p.S488S	MX1_uc002yzi.2_Silent_p.S488S|MX1_uc010goq.2_Silent_p.S488S	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	488					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				CAGATGTTTCGATAAAAAATT	0.313													5	461					0	0	0	0	A	42823125	A	A	42823125	2	1	36	1	0	0	0	0	0	0	0	1	10050	1045	37	1		1	MX1	21	42823125	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1657653	42823125	5306770	990	7790											
SIK1	150094	broad.mit.edu	37	chr21	44841567	44841567	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaggaggttctcggtcttGaggtcccggtggacgatgtg	6	10	17	8	3	2	1	0	1	2	0	4	4	3	3	1	6	1	2	1	6	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:44841567G>C	uc002zdf.2	-	5	577	c.450C>G	c.(448-450)CTC>CTG	p.L150L		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	150	Protein kinase.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						TCTCGGTCTTGAGGTCCCGGT	0.617													12	51					0	0	0	0	C	44841567	C	C	44841567	2	2	36	1	0	0	0	0	0	0	0	1	14382	1277	45	2		2	SIK1	21	44841567	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2018442	44841567	3288328	991	7791											
RRP1B	23076	broad.mit.edu	37	chr21	45107740	45107740	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagcagtgttgcccccagaGgacatgtctcagagtggccc	8	8	12	13	0	2	2	2	0	1	2	3	3	2	3	3	2	2	2	3	2	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:45107740G>A	uc002zdk.2	+	13	1599	c.1485G>A	c.(1483-1485)GAG>GAA	p.E495E	RRP1B_uc002zdl.2_Silent_p.E28E	NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	495					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		TGCCCCCAGAGGACATGTCTC	0.577													24	98					0	0	0	0	A	45107740	A	A	45107740	2	1	36	1	0	0	0	0	0	0	0	1	13753	991	35	4		4	RRP1B	21	45107740	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	266173	45107740	3022155	992	7792											
C21orf33	8209	broad.mit.edu	37	chr21	45554008	45554008	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtctggatgcggagtctacGatgggaccgagatccacgag	9	8	15	9	4	2	1	0	0	2	1	3	7	3	4	2	3	2	0	2	3	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:45554008G>A	uc002zec.3	+	2	252	c.166G>A	c.(166-168)GAT>AAT	p.D56N	C21orf33_uc002zed.3_Missense_Mutation_p.D56N	NM_004649	NP_004640	P30042	ES1_HUMAN	es1 protein isoform Ia precursor	56						mitochondrion				ovary(1)	1				STAD - Stomach adenocarcinoma(101;0.168)|Colorectal(79;0.191)		CGGAGTCTACGATGGGACCGA	0.672													7	29					0	0	0	0	A	45554008	A	A	45554008	3	1	36	1	0	0	0	0	1	0	0	0	2135	1058	37	1	172	1	C21orf33	21	45554008	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	446268	45554008	2575887	993	7793											
TRPM2	7226	broad.mit.edu	37	chr21	45826645	45826645	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagatcccgggctacatcGacggtaggagccgggcgcca	8	4	16	13	5	0	1	0	0	0	1	2	3	1	2	3	5	2	3	3	5	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:45826645G>T	uc002zet.1	+	20	3172	c.2959G>T	c.(2959-2961)GAC>TAC	p.D987Y	TRPM2_uc002zeu.1_Missense_Mutation_p.D987Y|TRPM2_uc002zew.1_Missense_Mutation_p.D987Y|TRPM2_uc010gpt.1_Missense_Mutation_p.D987Y|TRPM2_uc002zex.1_Missense_Mutation_p.D773Y|TRPM2_uc002zey.1_Missense_Mutation_p.D500Y	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	987	Extracellular (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGGCTACATCGACGGTAGGAG	0.667													6	12					0.00116845	0.00118983	1	0	T	45826645	T	T	45826645	3	4	36	1	0	0	0	0	1	0	0	0	16653	1058	37	3	3033	3	TRPM2	21	45826645	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	272637	45826645	2303250	994	7794											
TRPM2	7226	broad.mit.edu	37	chr21	45838391	45838391	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tacctccagaaccgacagttCcagcaaaagcagcggcccga	13	4	9	15	3	0	1	0	0	0	1	2	3	2	1	5	1	5	3	5	1	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr21:45838391C>T	uc002zet.1	+	23	3627	c.3414C>T	c.(3412-3414)TTC>TTT	p.F1138F	TRPM2_uc002zeu.1_Silent_p.F1138F|TRPM2_uc002zew.1_Silent_p.F1138F|TRPM2_uc010gpt.1_Silent_p.F1138F|TRPM2_uc002zex.1_Silent_p.F924F|TRPM2_uc002zey.1_Silent_p.F651F|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1138	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACCGACAGTTCCAGCAAAAGC	0.612													37	140					0	0	0	0	T	45838391	T	T	45838391	2	4	36	1	0	0	0	0	0	0	0	1	16653	854	30	2		2	TRPM2	21	45838391	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	11746	45838391	2291504	995	7795											
IL17RA	23765	broad.mit.edu	37	chr22	17583169	17583169	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggagaaccacagttgctttGagcacatgcaccacatacct	12	9	8	12	0	0	2	0	1	0	1	0	3	0	2	3	1	5	4	3	1	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:17583169G>C	uc002zly.2	+	7	872	c.739G>C	c.(739-741)GAG>CAG	p.E247Q	IL17RA_uc010gqt.2_Missense_Mutation_p.E247Q	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	247	Extracellular (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		CAGTTGCTTTGAGCACATGCA	0.547													56	145					0	0	0	0	C	17583169	C	C	17583169	3	2	36	1	0	0	0	0	1	0	0	0	7678	1291	45	2	765	2	IL17RA	22	17583169	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08		17583169	33721397	996	7796											
CECR6	27439	broad.mit.edu	37	chr22	17601079	17601079	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ataagccaggccaggtaggcGaaggcgaactcgcccgctgc	10	4	14	13	4	0	0	0	0	0	0	1	2	0	0	3	4	3	2	3	4	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:17601079G>A	uc002zmb.2	-	1	1135	c.939C>T	c.(937-939)TTC>TTT	p.F313F	CECR6_uc002zma.2_Intron|uc002zmc.2_5'Flank	NM_031890	NP_114096	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	313	Ala-rich.										0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		CCAGGTAGGCGAAGGCGAACT	0.453													24	64					0	0	0	0	A	17601079	A	A	17601079	2	1	36	1	0	0	0	0	0	0	0	1	3223	1049	37	1		1	CECR6	22	17601079	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	17910	17601079	33703487	997	7797											
HSCB	150274	broad.mit.edu	37	chr22	29141879	29141879	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatggaatagagattcctGaaaggacagattatgaaatg	16	10	10	5	0	0	4	0	2	0	2	2	7	2	6	2	2	0	0	2	2	5	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:29141879G>A	uc003aea.2	+	4	492	c.451G>A	c.(451-453)GAA>AAA	p.E151K		NM_172002	NP_741999	Q8IWL3	HSC20_HUMAN	J-type co-chaperone HSC20 precursor	151					iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)	1						AGAGATTCCTGAAAGGACAGA	0.378													32	100					0	0	0	0	A	29141879	A	A	29141879	3	1	36	1	0	0	0	0	1	0	0	0	7413	1291	45	2	465	2	HSCB	22	29141879	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	11540800	29141879	22162687	998	7798											
DUSP18	150290	broad.mit.edu	37	chr22	31059444	31059444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacagtggaatcatcaaacGgacttccttctcatagatgt	12	12	7	10	1	4	1	4	0	1	1	6	3	5	3	1	2	1	0	1	2	3	3	rs142285924	by1000genomes	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:31059444G>A	uc003aiu.2	-	2	1048	c.547C>T	c.(547-549)CGT>TGT	p.R183C	SLC35E4_uc003ait.2_Intron|DUSP18_uc010gwa.1_RNA|DUSP18_uc003aiw.1_Missense_Mutation_p.R183C	NM_152511	NP_689724	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	183						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						ATCATCAAACGGACTTCCTTC	0.468													16	79					0	0	0	0	A	31059444	A	A	31059444	3	1	36	1	0	0	0	0	1	0	0	0	4839	1116	39	1	23	1	DUSP18	22	31059444	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1917565	31059444	20245122	999	7799											
OSBP2	23762	broad.mit.edu	37	chr22	31091253	31091253	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgtaggggctgggcccttCactaaggccgcatcggagcc	6	7	16	12	2	1	0	1	0	0	0	2	1	1	1	3	6	1	3	3	6	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:31091253C>T	uc003aiy.1	+	1	461	c.357C>T	c.(355-357)TTC>TTT	p.F119F	OSBP2_uc011ala.1_Intron|OSBP2_uc010gwc.1_Intron|OSBP2_uc003aix.1_Silent_p.F119F|OSBP2_uc011alb.1_Silent_p.F119F|OSBP2_uc003aiz.1_Silent_p.F119F	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	119					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						CTGGGCCCTTCACTAAGGCCG	0.682													22	55					0	0	0	0	T	31091253	T	T	31091253	2	4	36	1	0	0	0	0	0	0	0	1	11328	825	29	2		2	OSBP2	22	31091253	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	31809	31091253	20213313	1000	7800											
PIK3IP1	113791	broad.mit.edu	37	chr22	31685563	31685563	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatcactggctgcacagctgCcgcctcactccgagcgggca	8	6	11	16	3	2	0	2	0	0	0	3	1	3	0	3	2	4	4	3	2	1	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:31685563C>A	uc003akm.2	-	4	620	c.430G>T	c.(430-432)GCA>TCA	p.A144S	PIK3IP1_uc003akl.2_RNA|PIK3IP1_uc011alo.1_Missense_Mutation_p.A144S|PIK3IP1_uc003akn.2_Missense_Mutation_p.A124S|PIK3IP1_uc003ako.2_Missense_Mutation_p.A144S	NM_052880	NP_443112	Q96FE7	P3IP1_HUMAN	HGFL protein isoform 1	144	Extracellular (Potential).					integral to membrane				ovary(1)	1						TGCACAGCTGCCGCCTCACTC	0.617													4	6					0.000602214	0.000614259	1	0	A	31685563	A	A	31685563	3	1	36	1	0	0	0	0	1	0	0	0	11972	739	26	4	373	4	PIK3IP1	22	31685563	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	594310	31685563	19619003	1001	7801											
SFI1	9814	broad.mit.edu	37	chr22	32014301	32014301	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccctccatggccccaggTggaaatgcagatccagctgc	8	8	11	14	0	0	1	0	0	0	1	3	2	3	2	5	3	3	2	5	3	1	0	rs111513493		TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:32014301T>A	uc003ale.2	+	33	4019	c.3626T>A	c.(3625-3627)GTG>GAG	p.V1209E	SFI1_uc003alf.2_Missense_Mutation_p.V1178E|SFI1_uc003alg.2_Missense_Mutation_p.V1127E|SFI1_uc011alp.1_Missense_Mutation_p.V1115E|SFI1_uc011alq.1_Missense_Mutation_p.V1154E|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA|SFI1_uc003ali.2_Missense_Mutation_p.V301E|SFI1_uc003alj.2_Missense_Mutation_p.V343E	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	1209					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						TGGCCCCAGGTGGAAATGCAG	0.701													10	26					0	0	0	0	A	32014301	A	A	32014301	3	1	36	1	0	0	0	0	1	0	0	0	14221	1710	59	5	3752	5	SFI1	22	32014301	Missense_Mutation	SNP	T	TCGA-CN-4723-01A-01D-1434-08	328738	32014301	19290265	1002	7802											
MCM5	4174	broad.mit.edu	37	chr22	35817335	35817335	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggaggccattgtgcgcatCgcggaagccctcagcaagat	9	7	13	12	3	1	1	1	0	0	1	2	3	1	3	2	3	3	2	2	3	2	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:35817335C>T	uc003anu.3	+	15	1951	c.1857C>T	c.(1855-1857)ATC>ATT	p.I619I	MCM5_uc010gwr.2_Silent_p.I428I|MCM5_uc003anv.3_Silent_p.I576I|MCM5_uc003anw.1_Silent_p.I403I	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	619					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						TTGTGCGCATCGCGGAAGCCC	0.637													30	73					0	0	0	0	T	35817335	T	T	35817335	2	4	36	1	0	0	0	0	0	0	0	1	9443	874	31	1		1	MCM5	22	35817335	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3803034	35817335	15487231	1003	7803											
MYH9	4627	broad.mit.edu	37	chr22	36708220	36708220	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcttgtcggtggctttgggGaaccagcactcctcgtccag	5	11	12	13	2	1	0	0	0	1	0	5	1	3	1	3	4	2	2	3	4	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:36708220G>A	uc003apg.2	-	14	1833	c.1602C>T	c.(1600-1602)TTC>TTT	p.F534F	MYH9_uc003aph.1_Silent_p.F398F	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	534	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGGCTTTGGGGAACCAGCACT	0.632			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				36	111					0	0	0	0	A	36708220	A	A	36708220	2	1	36	1	0	0	0	0	0	0	0	1	10095	1165	41	2		2	MYH9	22	36708220	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	890885	36708220	14596346	1004	7804											
SSTR3	6753	broad.mit.edu	37	chr22	37603432	37603432	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccaggtagcggtccacgctCatgacagtcaggcagaatat	11	7	12	11	2	2	2	2	1	0	1	3	2	3	2	2	3	1	3	2	3	3	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:37603432C>G	uc003ara.2	-	2	473	c.411G>C	c.(409-411)ATG>ATC	p.M137I	SSTR3_uc003arb.2_Missense_Mutation_p.M137I	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	137	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						GGTCCACGCTCATGACAGTCA	0.667													34	94					0	0	0	0	G	37603432	G	G	37603432	3	3	36	1	0	0	0	0	1	0	0	0	15265	826	29	2	849	2	SSTR3	22	37603432	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	895212	37603432	13701134	1005	7805											
CARD10	29775	broad.mit.edu	37	chr22	37888526	37888526	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgggggctccaggcgctgaGgatgggcacagttcctcccc	5	8	15	13	1	0	1	0	1	0	0	3	2	3	2	4	5	0	4	4	5	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:37888526G>A	uc003asx.1	-	18	2670	c.2667C>T	c.(2665-2667)TCC>TCT	p.S889S	CARD10_uc003ast.1_RNA|CARD10_uc003asu.1_5'UTR|CARD10_uc003asv.1_5'UTR|CARD10_uc011ank.1_Silent_p.S207S|CARD10_uc003asw.1_Silent_p.S603S|CARD10_uc003asy.1_Silent_p.S889S	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	889					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					CAGGCGCTGAGGATGGGCACA	0.667													21	49					0	0	0	0	A	37888526	A	A	37888526	2	1	36	1	0	0	0	0	0	0	0	1	2656	987	35	4		4	CARD10	22	37888526	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	285094	37888526	13416040	1006	7806											
CSNK1E	1454	broad.mit.edu	37	chr22	38696025	38696026	+	Missense_Mutation	DNP	AT	TG	TG																															gggagcccaggttgaagtacAtgagcacgtagcccaggctc																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:38696025_38696026AT>TG	uc003avj.2	-	6	871_872	c.610_611AT>CA	c.(610-612)ATG>CAG	p.M204Q	CSNK1E_uc003avk.2_Missense_Mutation_p.M204Q|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Missense_Mutation_p.M204Q|CSNK1E_uc003avo.2_Missense_Mutation_p.M204Q|CSNK1E_uc003avp.1_Missense_Mutation_p.M204Q|CSNK1E_uc003avq.1_Missense_Mutation_p.M204Q	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	204	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)					GTTGAAGTACATGAGCACGTAG	0.579													29	89					0	0	0	0	TG	38696026	TG	TG	38696025	3	4	36	1	0	0	0	0	1	0	0	0	3970	217	8	5	659	5	CSNK1E	22	38696025	Missense_Mutation	DNP	AT	TCGA-CN-4723-01A-01D-1434-08	807499	38696025	12608541	1007	7807											
CACNA1I	8911	broad.mit.edu	37	chr22	40060842	40060842	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttcgtgtccatcatcgacatCgtggtgtccctggcctcagc	5	12	10	14	3	2	0	2	0	0	0	7	1	4	0	3	2	1	0	3	2	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:40060842C>G	uc003ayc.2	+	21	3765	c.3765C>G	c.(3763-3765)ATC>ATG	p.I1255M	CACNA1I_uc003ayd.2_Missense_Mutation_p.I1220M|CACNA1I_uc003aye.2_Missense_Mutation_p.I1170M|CACNA1I_uc003ayf.2_Missense_Mutation_p.I1135M	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1255	Helical; Name=S3 of repeat III; (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TCATCGACATCGTGGTGTCCC	0.642													11	61					0	0	0	0	G	40060842	G	G	40060842	3	3	36	1	0	0	0	0	1	0	0	0	2558	874	31	3	3847	3	CACNA1I	22	40060842	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1364817	40060842	11243724	1008	7808											
ST13	6767	broad.mit.edu	37	chr22	41226906	41226906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctattctttctttgatctCtcgctcttcacgttttcgct	3	22	4	12	3	6	1	1	1	5	0	9	1	6	1	0	0	0	3	0	0	1	8	rs148186652	byFrequency	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:41226906C>T	uc003aze.2	-	9	879	c.736G>A	c.(736-738)GAG>AAG	p.E246K	ST13_uc011aow.1_Missense_Mutation_p.E236K	NM_003932	NP_003923	P50502	F10A1_HUMAN	heat shock 70kD protein binding protein	246							protein binding, bridging				0						TCTTTGATCTCTCGCTCTTCA	0.413													32	130					0	0	0	0	T	41226906	T	T	41226906	3	4	36	1	0	0	0	0	1	0	0	0	15276	922	32	2	389	2	ST13	22	41226906	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1166064	41226906	10077660	1009	7809											
PACSIN2	11252	broad.mit.edu	37	chr22	43287098	43287098	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaagtcatcgttcatcagtGaggccttcacctcgaggtgc	8	10	11	12	3	4	1	4	1	0	0	6	3	4	1	2	2	1	1	2	2	1	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:43287098G>T	uc010gzg.2	-	4	530	c.308C>A	c.(307-309)TCA>TAA	p.S103*	PACSIN2_uc003bdg.3_Nonsense_Mutation_p.S103*|PACSIN2_uc003bde.3_Nonsense_Mutation_p.S103*|PACSIN2_uc003bdf.3_Nonsense_Mutation_p.S103*	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	103					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				GTTCATCAGTGAGGCCTTCAC	0.582													20	83					1.64113e-05	1.68519e-05	1	0	T	43287098	T	T	43287098	4	4	36	1	0	0	0	0	0	1	0	0	11429	1294	45	2	1184	2	PACSIN2	22	43287098	Nonsense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2060192	43287098	8017468	1010	7810											
PLXNB2	23654	broad.mit.edu	37	chr22	50718104	50718104	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagcagccccgtgtcgttGagagtgtacttggccttctt	5	12	11	13	2	1	1	0	1	1	1	2	2	1	1	4	1	3	3	4	1	1	5	rs149176335	by1000genomes	TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chr22:50718104G>C	uc003bkv.3	-	27	4450	c.4344C>G	c.(4342-4344)CTC>CTG	p.L1448L	PLXNB2_uc003bkt.1_Silent_p.L240L|PLXNB2_uc003bku.1_Silent_p.L433L	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1448	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCGTGTCGTTGAGAGTGTACT	0.617													4	276					0	0	0	0	C	50718104	C	C	50718104	2	2	36	1	0	0	0	0	0	0	0	1	12179	1277	45	2		2	PLXNB2	22	50718104	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	7431006	50718104	586462	1011	7811											
SLC25A6	293	broad.mit.edu	37	chrX	1508132	1508132	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgcgatggcagccacacgtAcccttggccgtatcgtacac	8	8	10	15	5	0	0	0	0	0	0	2	1	0	0	3	2	3	4	3	2	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:1508132A>G	uc004cpt.2	-	2	694	c.598_splice	c.e2+1	p.G200_splice	SLC25A6_uc004cpu.2_Splice_Site	NM_001636	NP_001627	P12236	ADT3_HUMAN	adenine nucleotide translocator 3						active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	agccACACGTACCCTTGGCCG	0.338													9	108					0	0	0	0	G	1508132	G	G	1508132	5	3	36	1	0	0	0	0	0	0	1	0	14577	405	14	5	308	5	SLC25A6	23	1508132	Splice_Site	SNP	A	TCGA-CN-4723-01A-01D-1434-08		1508132	153762428	1012	7812											
NLGN4X	57502	broad.mit.edu	37	chrX	6069472	6069472	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgcagaccggggtgaacaaCaaaggaagccatagcagtcc	15	3	12	11	2	0	2	0	1	0	1	1	3	1	3	3	3	4	2	3	3	5	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:6069472C>T	uc010ndh.2	-	2	537	c.36G>A	c.(34-36)TTG>TTA	p.L12L	NLGN4X_uc004crp.2_Silent_p.L12L|NLGN4X_uc004crq.2_Silent_p.L12L|NLGN4X_uc010ndi.2_Silent_p.L12L|NLGN4X_uc004crr.2_Silent_p.L12L|NLGN4X_uc010ndj.2_Silent_p.L12L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	12					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GGGTGAACAACAAAGGAAGCC	0.522													19	26					0	0	0	0	T	6069472	T	T	6069472	2	4	36	1	0	0	0	0	0	0	0	1	10518	477	17	4		4	NLGN4X	23	6069472	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	4561340	6069472	149201088	1013	7813											
SHROOM2	357	broad.mit.edu	37	chrX	9900879	9900879	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agaaactgacggacaaacctCccctgctcatccaggatgag	13	6	9	13	1	1	3	1	2	0	1	3	5	3	5	4	2	3	1	4	2	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:9900879C>G	uc004csu.1	+	6	3646	c.3556C>G	c.(3556-3558)CCC>GCC	p.P1186A	SHROOM2_uc004csv.2_Missense_Mutation_p.P21A|SHROOM2_uc011mic.1_Missense_Mutation_p.P21A|SHROOM2_uc004csw.1_Missense_Mutation_p.P21A	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1186					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				GGACAAACCTCCCCTGCTCAT	0.637													18	15					0	0	0	0	G	9900879	G	G	9900879	3	3	36	1	0	0	0	0	1	0	0	0	14359	855	30	2	3578	2	SHROOM2	23	9900879	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3831407	9900879	145369681	1014	7814											
DCAF8L1	139425	broad.mit.edu	37	chrX	27999220	27999220	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgctttcaagttcgacgtCttcacttgaactttctgagt	8	16	7	10	2	4	2	2	2	2	0	5	3	4	2	0	0	2	2	0	0	2	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:27999220C>G	uc004dbx.1	-	1	347	c.232G>C	c.(232-234)GAC>CAC	p.D78H		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	78	Glu-rich.									ovary(3)|skin(1)	4						AGTTCGACGTCTTCACTTGAA	0.398													46	62					0	0	0	0	G	27999220	G	G	27999220	3	3	36	1	0	0	0	0	1	0	0	0	4294	913	32	2	1574	2	DCAF8L1	23	27999220	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	18098341	27999220	127271340	1015	7815											
CXorf21	80231	broad.mit.edu	37	chrX	30578276	30578276	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctctcttgaatgcactgaaGagataaacttgccagatgat	13	12	8	8	0	2	5	0	3	2	2	3	6	2	5	1	0	3	1	1	0	4	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:30578276G>C	uc004dcg.1	-	3	473	c.197C>G	c.(196-198)TCT>TGT	p.S66C		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	66										ovary(1)	1						ATGCACTGAAGAGATAAACTT	0.458													110	98					0	0	0	0	C	30578276	C	C	30578276	3	2	36	1	0	0	0	0	1	0	0	0	4118	942	33	2	712	2	CXorf21	23	30578276	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2579056	30578276	124692284	1016	7816											
CXorf22	170063	broad.mit.edu	37	chrX	35974208	35974208	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgttcagaaattcagtgcatCataaaaaatcaatgcgaatt	17	11	6	7	2	4	1	4	0	0	1	4	2	4	1	0	0	2	2	0	0	6	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:35974208C>G	uc004ddj.2	+	8	1364	c.1305C>G	c.(1303-1305)ATC>ATG	p.I435M	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	435										large_intestine(1)|lung(1)|ovary(1)	3						TTCAGTGCATCATAAAAAATC	0.378													44	34					0	0	0	0	G	35974208	G	G	35974208	3	3	36	1	0	0	0	0	1	0	0	0	4119	816	29	2	1335	2	CXorf22	23	35974208	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	5395932	35974208	119296352	1017	7817											
DDX3X	1654	broad.mit.edu	37	chrX	41196718	41196719	+	Splice_Site	INS	-	G	G																															tggaggaagtacagccagcaINSgtaagtacaacatcttgtgg																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:41196718_41196719insG	uc004dfe.2	+	2	958	c.103_splice	c.e2+1	p.K35_splice	DDX3X_uc004dfd.1_Splice_Site|DDX3X_uc010nhf.1_Splice_Site_p.S35_splice|DDX3X_uc004dff.2_Splice_Site_p.K35_splice|DDX3X_uc011mkq.1_Splice_Site_p.S35_splice|DDX3X_uc011mkr.1_Splice_Site_p.K35_splice|DDX3X_uc011mks.1_Splice_Site_p.K35_splice|DDX3X_uc004dfg.2_Splice_Site|DDX3X_uc011mkt.1_Splice_Site	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3						interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						TACAGCCAGCAGTAAGTACAAC	0.371										HNSCC(61;0.18)			---	---	---								G	41196719	G	G	41196718	8	5	36	1	0	1	1	0	0	0	1	0	4375	202	7	0	109	0	DDX3X	23	41196718	Splice_Site	INS	-	TCGA-CN-4723-01A-01D-1434-08	5222510	41196718	114073842	1018	7818											
DGKK	139189	broad.mit.edu	37	chrX	50167295	50167295	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccttgaaccagaaaatatCtaagcttccatctcttgaaa	14	12	5	10	0	2	3	0	2	2	1	5	3	4	3	3	0	2	1	3	0	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:50167295C>G	uc010njr.1	-	2	767	c.707G>C	c.(706-708)AGA>ACA	p.R236T		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	236	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					CAGAAAATATCTAAGCTTCCA	0.403													12	26					0	0	0	0	G	50167295	G	G	50167295	3	3	36	1	0	0	0	0	1	0	0	0	4494	913	32	2	3215	2	DGKK	23	50167295	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	8970577	50167295	105103265	1019	7819											
WNK3	65267	broad.mit.edu	37	chrX	54324818	54324818	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatggtttaataggtccctGatagacaacctaataaacaa	16	10	7	8	0	0	2	0	1	0	1	1	2	1	2	2	2	2	2	2	2	8	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:54324818G>C	uc004dtd.1	-	7	1627	c.1188C>G	c.(1186-1188)ATC>ATG	p.I396M	WNK3_uc004dtc.1_Missense_Mutation_p.I396M	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	396	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						ATAGGTCCCTGATAGACAACC	0.333													46	26					0	0	0	0	C	54324818	C	C	54324818	3	2	36	1	0	0	0	0	1	0	0	0	17447	1280	45	2	4286	2	WNK3	23	54324818	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4157523	54324818	100945742	1020	7820											
ALAS2	212	broad.mit.edu	37	chrX	55039985	55039985	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caagcgcaggagctcttcacCccgggggacagttgggtagt	8	7	15	11	2	2	0	1	0	1	0	2	2	2	2	2	4	2	4	2	4	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:55039985C>G	uc004dua.3	-	10	1672	c.1534G>C	c.(1534-1536)GGT>CGT	p.G512R	ALAS2_uc004dub.3_Missense_Mutation_p.G499R|ALAS2_uc004dud.3_Missense_Mutation_p.G475R	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	512					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	AGCTCTTCACCCCGGGGGACA	0.572													17	44					0	0	0	0	G	55039985	G	G	55039985	3	3	36	1	0	0	0	0	1	0	0	0	485	623	22	4	237	4	ALAS2	23	55039985	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	715167	55039985	100230575	1021	7821											
VSIG4	11326	broad.mit.edu	37	chrX	65242121	65242121	+	Frame_Shift_Del	DEL	C	-	-																															atttttaacagacacttttgCcctcagtggccagaaactca																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:65242121delC	uc004dwh.2	-	8	1311	c.1184delG	c.(1183-1185)GGCfs	p.G395fs	VSIG4_uc004dwi.2_Frame_Shift_Del_p.G301fs|VSIG4_uc010nkq.1_3'UTR|VSIG4_uc004dwj.2_3'UTR|VSIG4_uc011moy.1_3'UTR|VSIG4_uc004dwk.2_3'UTR|VSIG4_uc004dwl.2_Intron	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	395	Cytoplasmic (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						GACACTTTTGCCCTCAGTGGC	0.512													---	---	---								-	65242121	-	-	65242121	7	5	36	1	0	1	0	1	0	0	0	0	17293	739	26	0	19	0	VSIG4	23	65242121	Frame_Shift_Del	DEL	C	TCGA-CN-4723-01A-01D-1434-08	10202136	65242121	90028439	1022	7822											
HEPH	9843	broad.mit.edu	37	chrX	65479995	65479995	+	Frame_Shift_Del	DEL	G	-	-																															ctgttcccagggacttttgaGgttgtggagatggtggccag																										TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:65479995delG	uc011moz.1	+	19	3159	c.3099delG	c.(3097-3099)GAGfs	p.E1033fs	HEPH_uc004dwn.2_Frame_Shift_Del_p.E1033fs|HEPH_uc004dwo.2_Frame_Shift_Del_p.E763fs|HEPH_uc010nkr.2_Frame_Shift_Del_p.E841fs|HEPH_uc011mpa.1_Frame_Shift_Del_p.E1033fs	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1030	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						GGACTTTTGAGGTTGTGGAGA	0.517													---	---	---								-	65479995	-	-	65479995	7	5	36	1	0	1	0	1	0	0	0	0	7093	991	35	0	3326	0	HEPH	23	65479995	Frame_Shift_Del	DEL	G	TCGA-CN-4723-01A-01D-1434-08	237874	65479995	89790565	1023	7823											
DGAT2L6	347516	broad.mit.edu	37	chrX	69420191	69420191	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctcttttggtgtcttcatCaactttgccactgaggccac	6	15	7	13	0	4	1	2	1	2	0	5	1	4	1	2	2	2	0	2	2	1	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:69420191C>A	uc004dxx.1	+	4	451	c.354C>A	c.(352-354)ATC>ATA	p.I118I		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	118	Helical; (Potential).				lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						GTGTCTTCATCAACTTTGCCA	0.463													37	39					3.66082e-28	3.92712e-28	1	0	A	69420191	A	A	69420191	2	1	36	1	0	0	0	0	0	0	0	1	4481	816	29	2		2	DGAT2L6	23	69420191	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3940196	69420191	85850369	1024	7824											
OGT	8473	broad.mit.edu	37	chrX	70776821	70776821	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatcagtcctacctttgctGatgcctactctaatatggga	10	13	8	10	0	2	1	1	1	1	0	3	3	3	2	3	1	4	1	3	1	5	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:70776821G>A	uc004eaa.1	+	10	1403	c.1186G>A	c.(1186-1188)GAT>AAT	p.D396N	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.D386N|OGT_uc004eac.2_Missense_Mutation_p.D257N|OGT_uc004ead.2_Missense_Mutation_p.D15N	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	396	TPR 11.				cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					TACCTTTGCTGATGCCTACTC	0.393													35	24					0	0	0	0	A	70776821	A	A	70776821	3	1	36	1	0	0	0	0	1	0	0	0	10901	1290	45	2	1224	2	OGT	23	70776821	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	1356630	70776821	84493739	1025	7825											
KIAA2022	340533	broad.mit.edu	37	chrX	73961334	73961334	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagtcatcagtgatatcatCatcgccatccttttcacagg	11	12	7	11	1	5	1	5	1	0	0	7	2	6	1	2	1	0	0	2	1	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:73961334C>T	uc004eby.2	-	3	3675	c.3058G>A	c.(3058-3060)GAT>AAT	p.D1020N		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1020					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GTGATATCATCATCGCCATCC	0.473													43	49					0	0	0	0	T	73961334	T	T	73961334	3	4	36	1	0	0	0	0	1	0	0	0	8308	826	29	2	1500	2	KIAA2022	23	73961334	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	3184513	73961334	81309226	1026	7826											
ABCB7	22	broad.mit.edu	37	chrX	74288934	74288934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgctacccttttgaggctCatagaagcgaaataatagcc	14	10	8	9	1	1	2	1	1	0	1	1	3	1	2	2	1	4	2	2	1	7	6			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:74288934C>T	uc004eca.2	-	12	1592	c.1567G>A	c.(1567-1569)GAG>AAG	p.E523K	ABCB7_uc004ebz.2_Missense_Mutation_p.E524K|ABCB7_uc011mqn.1_Missense_Mutation_p.E497K|ABCB7_uc010nls.2_Missense_Mutation_p.E484K|ABCB7_uc010nlt.2_Missense_Mutation_p.E483K	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	523	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						TTTTGAGGCTCATAGAAGCGA	0.403													70	61					0	0	0	0	T	74288934	T	T	74288934	3	4	36	1	0	0	0	0	1	0	0	0	46	835	29	2	711	2	ABCB7	23	74288934	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	327600	74288934	80981626	1027	7827											
ATRX	546	broad.mit.edu	37	chrX	76891448	76891448	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgataaccatatttctatGaacctgcactaaaggttctt	12	16	5	8	0	2	2	0	2	2	0	2	2	2	2	2	1	3	2	2	1	6	8			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:76891448G>C	uc004ecp.3	-	16	4889	c.4657C>G	c.(4657-4659)CAT>GAT	p.H1553D	ATRX_uc004ecq.3_Missense_Mutation_p.H1515D|ATRX_uc004eco.3_Missense_Mutation_p.H1338D	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1553					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATATTTCTATGAACCTGCACT	0.323			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						27	14					0	0	0	0	C	76891448	C	C	76891448	3	2	36	1	0	0	0	0	1	0	0	0	1210	1290	45	2	2901	2	ATRX	23	76891448	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	2602514	76891448	78379112	1028	7828											
ZCCHC5	203430	broad.mit.edu	37	chrX	77913599	77913599	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctctggggctgctggggcctCctggagttcccaggctgctg	2	10	16	13	0	1	0	0	0	1	0	3	1	3	1	3	6	2	5	3	6	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:77913599C>T	uc004edc.1	-	2	615	c.319G>A	c.(319-321)GAG>AAG	p.E107K		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	107	Pro-rich.						nucleic acid binding|zinc ion binding			ovary(1)	1						GCTGGGGCCTCCTGGAGTTCC	0.637													8	13					0	0	0	0	T	77913599	T	T	77913599	3	4	36	1	0	0	0	0	1	0	0	0	17658	864	30	2	1112	2	ZCCHC5	23	77913599	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1022151	77913599	77356961	1029	7829											
BRWD3	254065	broad.mit.edu	37	chrX	79999617	79999617	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatactcttactaccttatCacagctgcctgcagcaataa	12	11	4	14	0	2	0	1	0	1	0	2	0	2	0	3	0	7	3	3	0	6	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:79999617C>T	uc004edt.2	-	8	990	c.727G>A	c.(727-729)GAT>AAT	p.D243N	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_Missense_Mutation_p.D72N|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_5'UTR|BRWD3_uc004edr.2_5'UTR|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_5'UTR|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_5'UTR|BRWD3_uc004eea.2_5'UTR|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	243	WD 3.									ovary(4)	4						ACTACCTTATCACAGCTGCCT	0.443													52	42					0	0	0	0	T	79999617	T	T	79999617	3	4	36	1	0	0	0	0	1	0	0	0	1531	826	29	2	4817	2	BRWD3	23	79999617	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	2086018	79999617	75270943	1030	7830											
ZMAT1	84460	broad.mit.edu	37	chrX	101139594	101139594	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaaatgggagtctttgttCaaacattctatgtctgggtc	9	15	9	8	0	5	0	2	0	3	0	6	1	5	1	0	2	1	1	0	2	3	4			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:101139594C>G	uc004eim.2	-	2	3790	c.292G>C	c.(292-294)GAA>CAA	p.E98Q	ZMAT1_uc011mrl.1_Missense_Mutation_p.E269Q|ZMAT1_uc004ein.2_Missense_Mutation_p.E98Q|ZMAT1_uc011mrm.1_Missense_Mutation_p.E98Q	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	98						nucleus	zinc ion binding			ovary(1)	1						AGTCTTTGTTCAAACATTCTA	0.413													80	56					0	0	0	0	G	101139594	G	G	101139594	3	3	36	1	0	0	0	0	1	0	0	0	17758	835	29	2	1115	2	ZMAT1	23	101139594	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	21139977	101139594	54130966	1031	7831											
TCEAL2	140597	broad.mit.edu	37	chrX	101382452	101382452	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggggtggctgcagggcccCacgaagggacactgaagaca	11	3	16	11	1	0	2	0	1	0	1	0	4	0	3	2	5	1	2	2	5	2	0			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:101382452C>T	uc004eip.2	+	3	869	c.650C>T	c.(649-651)CCA>CTA	p.P217L		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						TGCAGGGCCCCACGAAGGGAC	0.473													46	73					0	0	0	0	T	101382452	T	T	101382452	3	4	36	1	0	0	0	0	1	0	0	0	15737	594	21	4	652	4	TCEAL2	23	101382452	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	242858	101382452	53888108	1032	7832											
TCEAL5	340543	broad.mit.edu	37	chrX	102528931	102528931	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctccgcccctcactcccctCacaccccgttggccccttgg	3	8	6	24	2	2	0	2	0	0	0	4	0	4	0	10	2	0	1	10	2	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:102528931C>G	uc004ejz.1	-	3	856	c.561G>C	c.(559-561)GTG>GTC	p.V187V		NM_001012979	NP_001012997	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(1)|breast(1)	2						TCACTCCCCTCACACCCCGTT	0.408													49	63					0	0	0	0	G	102528931	G	G	102528931	2	3	36	1	0	0	0	0	0	0	0	1	15740	813	29	2		2	TCEAL5	23	102528931	Silent	SNP	C	TCGA-CN-4723-01A-01D-1434-08	1146479	102528931	52741629	1033	7833											
PLP1	5354	broad.mit.edu	37	chrX	103041593	103041593	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggttccagaggccaacatCaagctcattctttggagcgg	9	9	13	10	1	3	1	2	0	1	1	4	2	4	2	2	5	3	2	2	5	2	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:103041593C>G	uc010nov.2	+	4	671	c.391C>G	c.(391-393)CAA>GAA	p.Q131E	RAB9B_uc004eli.1_Intron|PLP1_uc004elk.2_Missense_Mutation_p.Q131E|PLP1_uc004elj.2_Intron|PLP1_uc011msf.1_Missense_Mutation_p.Q76E|PLP1_uc010now.1_Missense_Mutation_p.Q135E|PLP1_uc010nox.2_Missense_Mutation_p.Q85E	NM_001128834	NP_001122306	P60201	MYPR_HUMAN	proteolipid protein 1 isoform 1	131	Cytoplasmic (Probable).		Missing (in HLD1).		cell death|synaptic transmission	integral to membrane				ovary(1)	1						AGGCCAACATCAAGCTCATTC	0.542													89	87					0	0	0	0	G	103041593	G	G	103041593	3	3	36	1	0	0	0	0	1	0	0	0	12159	827	29	2	401	2	PLP1	23	103041593	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	512662	103041593	52228967	1034	7834											
H2BFWT	158983	broad.mit.edu	37	chrX	103267305	103267305	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactttctctgttgctgtatGgcatacagtgaagttctgga	8	15	10	8	0	2	1	0	1	2	0	3	2	2	2	0	2	2	5	0	2	3	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:103267305G>A	uc004elr.2	-	2	531	c.507C>T	c.(505-507)GCC>GCT	p.A169A		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	169					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						gttgctgtatggcatacagtg	0.189													23	85					0	0	0	0	A	103267305	A	A	103267305	2	1	36	1	0	0	0	0	0	0	0	1	6971	1335	47	4		4	H2BFWT	23	103267305	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	225712	103267305	52003255	1035	7835											
ESX1	80712	broad.mit.edu	37	chrX	103499187	103499187	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccgcttctgttccgtactCaggtttggaccgtgtattct	4	17	9	11	3	3	0	1	0	2	0	5	1	5	1	3	2	1	5	3	2	2	7			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:103499187C>G	uc004ely.2	-	2	212	c.154G>C	c.(154-156)GAG>CAG	p.E52Q		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	52					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTTCCGTACTCAGGTTTGGAC	0.587													119	130					0	0	0	0	G	103499187	G	G	103499187	3	3	36	1	0	0	0	0	1	0	0	0	5287	835	29	2	1078	2	ESX1	23	103499187	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	231882	103499187	51771373	1036	7836											
DOCK11	139818	broad.mit.edu	37	chrX	117773418	117773418	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgcatgatgcctggctgtCaaaacacttcggaatagacc	11	9	11	10	1	1	2	1	1	0	1	2	3	1	3	2	3	3	2	2	3	4	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:117773418C>G	uc004eqp.2	+	38	4085	c.4022C>G	c.(4021-4023)TCA>TGA	p.S1341*	DOCK11_uc004eqq.2_Nonsense_Mutation_p.S1120*	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1341					blood coagulation	cytosol	GTP binding			ovary(3)	3						GCCTGGCTGTCAAAACACTTC	0.393													3	91					0	0	0	0	G	117773418	G	G	117773418	4	3	36	1	0	0	0	0	0	1	0	0	4708	838	29	2	4172	2	DOCK11	23	117773418	Nonsense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	14274231	117773418	37497142	1037	7837											
KIAA1210	57481	broad.mit.edu	37	chrX	118220824	118220824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgctggttattattaccatCaccactctcaagatcttctt	10	16	4	11	0	4	1	2	0	3	1	5	1	4	1	2	1	2	2	2	1	4	5			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:118220824C>T	uc004era.3	-	11	4369	c.4369G>A	c.(4369-4371)GAT>AAT	p.D1457N		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1457										ovary(4)|skin(1)	5						TTATTACCATCACCACTCTCA	0.453													31	32					0	0	0	0	T	118220824	T	T	118220824	3	4	36	1	0	0	0	0	1	0	0	0	8253	826	29	2	776	2	KIAA1210	23	118220824	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	447406	118220824	37049736	1038	7838											
BCORL1	63035	broad.mit.edu	37	chrX	129147430	129147430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccaggttcccctctccgtcCctgccccagtcccccattca	4	10	5	22	1	2	0	1	0	1	0	7	0	6	0	9	1	1	1	9	1	0	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:129147430C>T	uc004evb.1	+	4	796	c.682C>T	c.(682-684)CCT>TCT	p.P228S	BCORL1_uc010nrd.1_Missense_Mutation_p.P130S	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	228	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CCTCTCCGTCCCTGCCCCAGT	0.622													5	178					0	0	0	0	T	129147430	T	T	129147430	3	4	36	1	0	0	0	0	1	0	0	0	1389	623	22	4	692	4	BCORL1	23	129147430	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	10926606	129147430	26123130	1039	7839											
IDS	3423	broad.mit.edu	37	chrX	148577955	148577955	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcccgttgcctgatgtccatCcaggggttgtaggccacagg	6	10	13	12	1	0	1	0	1	0	0	3	1	3	1	5	4	1	3	5	4	1	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:148577955C>G	uc011mxe.1	-	6	999	c.801G>C	c.(799-801)TGG>TGC	p.W267C	IDS_uc011mxf.1_Missense_Mutation_p.W177C|IDS_uc011mxg.1_Missense_Mutation_p.W56C|IDS_uc010nsu.1_Intron|IDS_uc004fcw.3_Missense_Mutation_p.W56C|IDS_uc011mxh.1_Missense_Mutation_p.W267C|IDS_uc011mxi.1_RNA	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	267						lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					TGATGTCCATCCAGGGGTTGT	0.542													6	187					0	0	0	0	G	148577955	G	G	148577955	3	3	36	1	0	0	0	0	1	0	0	0	7542	856	30	2	897	2	IDS	23	148577955	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08	19430525	148577955	6692605	1040	7840											
IDS	3423	broad.mit.edu	37	chrX	148586602	148586602	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcgtttcggatccgagggcGacgcagacggagctcagaac	9	6	15	11	6	1	2	1	0	0	2	3	6	2	4	1	3	3	3	1	3	1	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:148586602G>A	uc011mxe.1	-	1	264	c.66C>T	c.(64-66)GTC>GTT	p.V22V	IDS_uc011mxf.1_5'UTR|IDS_uc011mxg.1_5'UTR|IDS_uc010nsu.1_Intron|IDS_uc004fcw.3_Intron|IDS_uc011mxh.1_Silent_p.V22V|IDS_uc011mxi.1_RNA|IDS_uc011mxj.1_Silent_p.V22V	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	22						lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					ATCCGAGGGCGACGCAGACGG	0.532													17	24					0	0	0	0	A	148586602	A	A	148586602	2	1	36	1	0	0	0	0	0	0	0	1	7542	1045	37	1		1	IDS	23	148586602	Silent	SNP	G	TCGA-CN-4723-01A-01D-1434-08	8647	148586602	6683958	1041	7841											
MAGEA11	4110	broad.mit.edu	37	chrX	148798247	148798247	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaaattgggtgcaggaaaaGtacctggtgtaccggcaggt	12	8	14	7	1	0	0	0	0	0	0	0	1	0	1	2	5	3	4	2	5	6	3			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:148798247G>C	uc004fdq.2	+	5	1203	c.1101G>C	c.(1099-1101)AAG>AAC	p.K367N	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.K338N	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	367	MAGE.					cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					TGCAGGAAAAGTACCTGGTGT	0.557													92	96					0	0	0	0	C	148798247	C	C	148798247	3	2	36	1	0	0	0	0	1	0	0	0	9216	1020	36	4	1128	4	MAGEA11	23	148798247	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	211645	148798247	6472313	1042	7842											
PLXNA3	55558	broad.mit.edu	37	chrX	153693806	153693806	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcatggtgacaccgagctgGacttctccgtggtctgggat	7	10	14	10	2	2	1	0	1	2	0	3	4	2	3	2	4	2	2	2	4	0	1			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrX:153693806G>A	uc004flm.2	+	12	2457	c.2284G>A	c.(2284-2286)GAC>AAC	p.D762N		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	762	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CACCGAGCTGGACTTCTCCGT	0.552													56	40					0	0	0	0	A	153693806	A	A	153693806	3	1	36	1	0	0	0	0	1	0	0	0	12176	1174	41	2	2326	2	PLXNA3	23	153693806	Missense_Mutation	SNP	G	TCGA-CN-4723-01A-01D-1434-08	4895559	153693806	1576754	1043	7843											
DDX3Y	8653	broad.mit.edu	37	chrY	15028313	15028313	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgagaggaggcccttcacCagtttcgctcaggaaaaagc	12	7	11	11	2	2	1	2	0	0	1	4	4	2	3	2	3	1	2	2	3	2	2			TCGA-CN-4723-01A-01D-1434-08	TCGA-CN-4723-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5d71c48-1a2d-4d7d-8f2c-e3a68352776b	6dbae798-f66d-4d95-9262-7408cf83ab15	g.chrY:15028313C>A	uc004fsu.1	+	14	1759	c.1450C>A	c.(1450-1452)CAG>AAG	p.Q484K	DDX3Y_uc004fsv.2_Missense_Mutation_p.Q484K|DDX3Y_uc010nww.1_Missense_Mutation_p.Q300K|DDX3Y_uc011nar.1_Missense_Mutation_p.Q481K	NM_001122665	NP_001116137	O15523	DDX3Y_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3,	484	Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|RNA binding				0						GGCCCTTCACCAGTTTCGCTC	0.398													14	161					0.00316338	0.00320793	1	0	A	15028313	A	A	15028313	3	1	36	1	0	0	0	0	1	0	0	0	4376	595	21	4	1500	4	DDX3Y	24	15028313	Missense_Mutation	SNP	C	TCGA-CN-4723-01A-01D-1434-08		15028313	44345253	1044	7844											
CAMTA1	23261	broad.mit.edu	37	chr1	6880243	6880243	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tattttctgtttccttagagCgtttcccaaagtgtattctg	7	19	7	8	1	2	1	0	0	2	1	4	1	4	1	2	0	1	3	2	0	4	8			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr1:6880243C>T	uc001aoi.2	+	2	255	c.48C>T	c.(46-48)AGC>AGT	p.S16S	CAMTA1_uc001aoh.2_RNA	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TTCCTTAGagcgtttcccaaa	0.199													8	114					0	0	0	0	T	6880243	T	T	6880243	2	4	37	1	0	0	0	0	0	0	0	1	2625	767	27	1		1	CAMTA1	1	6880243	Silent	SNP	C	TCGA-CN-4725-01A-01D-1434-08		6880243	242370378	1	7845											
HTR6	3362	broad.mit.edu	37	chr1	19992531	19992531	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacgggcgctgggtgctggcGcgcggcctctgcctgctctg	1	9	17	14	5	2	0	0	0	2	0	2	0	2	0	2	4	4	3	2	4	1	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr1:19992531G>A	uc001bcl.2	+	1	752	c.285G>A	c.(283-285)GCG>GCA	p.A95A		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	95	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	GGGTGCTGGCGCGCGGCCTCT	0.652													6	112					0	0	0	0	A	19992531	A	A	19992531	2	1	37	1	0	0	0	0	0	0	0	1	7490	1074	38	1		1	HTR6	1	19992531	Silent	SNP	G	TCGA-CN-4725-01A-01D-1434-08	13112288	19992531	229258090	2	7846											
KIAA1522	57648	broad.mit.edu	37	chr1	33235953	33235953	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagcccagcctcagtccgCtcgctggggcgcttctcctc	3	8	11	19	3	2	0	1	0	1	0	6	0	3	0	5	2	2	3	5	2	0	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr1:33235953C>T	uc001bvv.2	+	6	1132	c.996C>T	c.(994-996)CGC>CGT	p.R332R	KIAA1522_uc001bvu.1_Silent_p.R391R|KIAA1522_uc010ohm.1_Silent_p.R343R|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	332	Ser-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCTCAGTCCGCTCGCTGGGGC	0.687													17	44					0	0	0	0	T	33235953	T	T	33235953	2	4	37	1	0	0	0	0	0	0	0	1	8277	784	28	4		4	KIAA1522	1	33235953	Silent	SNP	C	TCGA-CN-4725-01A-01D-1434-08	13243422	33235953	216014668	3	7847											
RABGGTB	5876	broad.mit.edu	37	chr1	76260255	76260255	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttttgggagaagaacagAttaaacctgttaatcctgtc	13	12	8	8	0	0	3	0	0	0	3	2	4	1	3	2	1	2	1	2	1	5	4			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr1:76260255A>G	uc001dgy.1	+	9	987	c.916A>G	c.(916-918)ATT>GTT	p.I306V	MSH4_uc001dhd.1_5'Flank|RABGGTB_uc009wbt.1_RNA|RABGGTB_uc001dha.1_Missense_Mutation_p.D261G|RABGGTB_uc001dhc.1_RNA	NM_004582	NP_004573	P53611	PGTB2_HUMAN	RAB geranylgeranyltransferase, beta subunit	306					protein modification process|visual perception		metal ion binding|protein binding|Rab geranylgeranyltransferase activity			ovary(1)	1						AGAAGAACAGATTAAACCTGT	0.353													65	123					0	0	0	0	G	76260255	G	G	76260255	3	3	37	1	0	0	0	0	1	0	0	0	13033	333	12	5	950	5	RABGGTB	1	76260255	Missense_Mutation	SNP	A	TCGA-CN-4725-01A-01D-1434-08	43024302	76260255	172990366	4	7848											
C1orf110	339512	broad.mit.edu	37	chr1	162824983	162824983	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttagatggattcacagaatCtttctcttgggcttgtggtt	7	17	10	7	0	3	2	1	0	2	2	4	3	3	3	0	3	0	2	0	3	2	6			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr1:162824983C>A	uc001gck.2	-	4	656	c.481G>T	c.(481-483)GAT>TAT	p.D161Y	C1orf110_uc009wuw.1_Intron|C1orf110_uc009wux.1_Missense_Mutation_p.D160Y	NM_178550	NP_848645	Q86UF4	CA110_HUMAN	hypothetical protein LOC339512	161											0						TTCACAGAATCTTTCTCTTGG	0.468													146	580					3.50555e-50	3.94374e-50	1	0	A	162824983	A	A	162824983	3	1	37	1	0	0	0	0	1	0	0	0	1992	913	32	2	431	2	C1orf110	1	162824983	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08	86564728	162824983	86425638	5	7849											
F5	2153	broad.mit.edu	37	chr1	169529961	169529961	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcctggagccacagcgtcGtccatcttctccgcagggaa	7	7	12	15	4	2	0	0	0	2	0	5	2	3	2	4	3	2	1	4	3	1	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr1:169529961G>A	uc001ggg.1	-	4	562	c.417C>T	c.(415-417)GAC>GAT	p.D139D	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	139	F5/8 type A 1.|Plastocyanin-like 1.	Calcium (By similarity).			cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCACAGCGTCGTCCATCTTCT	0.517													76	147					0	0	0	0	A	169529961	A	A	169529961	2	1	37	1	0	0	0	0	0	0	0	1	5373	1136	40	1		1	F5	1	169529961	Silent	SNP	G	TCGA-CN-4725-01A-01D-1434-08	6704978	169529961	79720660	6	7850											
TNN	63923	broad.mit.edu	37	chr1	175086194	175086194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcgctacacctctgccaagGacggagagaccagggaggtt	10	6	14	11	2	1	1	0	0	1	1	1	5	1	4	3	4	3	2	3	4	2	2			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr1:175086194G>A	uc001gkl.1	+	10	2352	c.2239G>A	c.(2239-2241)GAC>AAC	p.D747N		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	747	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CTCTGCCAAGGACGGAGAGAC	0.642													84	143					0	0	0	0	A	175086194	A	A	175086194	3	1	37	1	0	0	0	0	1	0	0	0	16389	1174	41	2	2273	2	TNN	1	175086194	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	5556233	175086194	74164427	7	7851											
GPR37L1	9283	broad.mit.edu	37	chr1	202092540	202092540	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcattgtgggcaacctgtCggtcatgtgcatcgtgtggc	5	11	16	9	2	1	0	1	0	0	0	3	0	1	0	1	4	2	3	1	4	1	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr1:202092540C>T	uc001gxj.2	+	1	512	c.449C>T	c.(448-450)TCG>TTG	p.S150L		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	150	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2						GGCAACCTGTCGGTCATGTGC	0.572													50	64					0	0	0	0	T	202092540	T	T	202092540	3	4	37	1	0	0	0	0	1	0	0	0	6730	893	31	1	451	1	GPR37L1	1	202092540	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08	27006346	202092540	47158081	8	7852											
PXDN	7837	broad.mit.edu	37	chr2	1652573	1652573	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcaatgcggttgtgctcGcggaaccacagcgtgtgcat	7	9	15	10	4	0	0	0	0	0	0	1	1	0	1	1	3	5	4	1	3	2	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr2:1652573G>A	uc002qxa.2	-	17	3043	c.2979C>T	c.(2977-2979)CGC>CGT	p.R993R		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	993					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GGTTGTGCTCGCGGAACCACA	0.647													7	10					0	0	0	0	A	1652573	A	A	1652573	2	1	37	1	0	0	0	0	0	0	0	1	12912	1074	38	1		1	PXDN	2	1652573	Silent	SNP	G	TCGA-CN-4725-01A-01D-1434-08		1652573	241546800	9	7853											
ALMS1	7840	broad.mit.edu	37	chr2	73718322	73718322	+	Frame_Shift_Del	DEL	T	-	-																															tgctgcttctaaagcgaggaTgaatagtgagtttaactttg																										TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr2:73718322delT	uc002sje.1	+	12	9350	c.9239delT	c.(9238-9240)ATGfs	p.M3080fs	ALMS1_uc002sjf.1_Frame_Shift_Del_p.M3036fs|ALMS1_uc002sjg.2_Frame_Shift_Del_p.M2466fs|ALMS1_uc002sjh.1_Frame_Shift_Del_p.M2466fs	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3078					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						AAAGCGAGGATGAATAGTGAG	0.383													---	---	---								-	73718322	-	-	73718322	7	5	37	1	0	1	0	1	0	0	0	0	535	1464	51	0	9271	0	ALMS1	2	73718322	Frame_Shift_Del	DEL	T	TCGA-CN-4725-01A-01D-1434-08	72065749	73718322	169481051	10	7854											
DOK1	1796	broad.mit.edu	37	chr2	74782758	74782758	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctaagctttctgccctggaGatgctggagaactccttgta	8	12	10	11	0	1	2	0	0	1	2	2	4	2	2	3	2	4	3	3	2	3	4			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr2:74782758G>T	uc002sms.2	+	3	439	c.417G>T	c.(415-417)GAG>GAT	p.E139D	LOXL3_uc010ffm.1_5'Flank|LOXL3_uc002smp.1_5'Flank|LOXL3_uc002smq.1_5'Flank|LOXL3_uc010ffn.1_5'Flank|DOK1_uc002smr.2_5'UTR|DOK1_uc010ffo.2_5'UTR|DOK1_uc002smt.2_5'UTR|DOK1_uc002smu.2_5'UTR|DOK1_uc010yrz.1_Missense_Mutation_p.E128D|DOK1_uc002smv.2_5'UTR|DOK1_uc002smw.1_5'UTR	NM_001381	NP_001372	Q99704	DOK1_HUMAN	docking protein 1	139					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding				0						CTGCCCTGGAGATGCTGGAGA	0.587													46	86					2.59344e-38	2.84646e-38	1	0	T	74782758	T	T	74782758	3	4	37	1	0	0	0	0	1	0	0	0	4718	933	33	2	427	2	DOK1	2	74782758	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	1064436	74782758	168416615	11	7855											
SNRNP200	23020	broad.mit.edu	37	chr2	96944428	96944428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagctctgacaagtggtccGacaagtgacgatgggagatg	11	7	14	9	2	1	3	0	2	1	1	2	6	2	3	2	2	1	1	2	2	2	0			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr2:96944428G>A	uc002svu.2	-	38	5431	c.5345C>T	c.(5344-5346)TCG>TTG	p.S1782L	SNRNP200_uc002svt.2_Missense_Mutation_p.S392L|SNRNP200_uc010yuj.1_RNA	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1782						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						CAAGTGGTCCGACAAGTGACG	0.567													30	121					0	0	0	0	A	96944428	A	A	96944428	3	1	37	1	0	0	0	0	1	0	0	0	14916	1059	37	1	1097	1	SNRNP200	2	96944428	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	22161670	96944428	146254945	12	7856											
MARCO	8685	broad.mit.edu	37	chr2	119739968	119739968	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggagccacaggcctgaaaGgaagcaaaggggacacaggt	15	2	15	9	0	0	1	0	1	0	0	0	4	0	4	2	6	2	1	2	6	3	0	rs137938144		TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr2:119739968G>T	uc002tln.1	+	12	1177	c.1045G>T	c.(1045-1047)GGA>TGA	p.G349*	MARCO_uc010yyf.1_Nonsense_Mutation_p.G271*	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	349	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity	p.G349R(1)		ovary(3)|skin(2)|central_nervous_system(1)	6						AGGCCTGAAAGGAAGCAAAGG	0.567													74	164					2.17518e-87	2.50982e-87	1	0	T	119739968	T	T	119739968	4	4	37	1	0	0	0	0	0	1	0	0	9364	1001	35	4	1091	4	MARCO	2	119739968	Nonsense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	22795540	119739968	123459405	13	7857											
EVX2	344191	broad.mit.edu	37	chr2	176947052	176947052	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagcgccgcacttgatccgCgccagagccggagccaccca	8	4	12	17	5	0	2	0	1	0	1	1	3	1	3	6	1	3	2	6	1	1	2			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr2:176947052C>T	uc010zeu.1	-	2	739	c.553G>A	c.(553-555)GCG>ACG	p.A185T		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	185						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		ACTTGATCCGCGCCAGAGCCG	0.721													16	21					0	0	0	0	T	176947052	T	T	176947052	3	4	37	1	0	0	0	0	1	0	0	0	5319	768	27	1	883	1	EVX2	2	176947052	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08	57207084	176947052	66252321	14	7858											
TMEM198	130612	broad.mit.edu	37	chr2	220412557	220412557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgtgccctgctcactctgCgctggccccgcccactcacc	3	9	8	21	2	4	0	2	0	2	0	4	0	4	0	5	1	3	2	5	1	0	0			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr2:220412557C>T	uc002vme.2	+	4	1081	c.496C>T	c.(496-498)CGC>TGC	p.R166C	TMEM198_uc002vmf.2_Missense_Mutation_p.R166C	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	166	Leu-rich.					integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GCTCACTCTGCGCTGGCCCCG	0.706													19	23					0	0	0	0	T	220412557	T	T	220412557	3	4	37	1	0	0	0	0	1	0	0	0	16185	768	27	1	502	1	TMEM198	2	220412557	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08	43465505	220412557	22786816	15	7859											
ADAMTS9	56999	broad.mit.edu	37	chr3	64606848	64606848	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccaggctggggcagccgatCgcatctttgatcagaaacag	10	8	12	11	2	2	2	1	1	1	1	4	3	3	2	2	3	2	3	2	3	1	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr3:64606848C>T	uc003dmg.2	-	19	2787	c.2755G>A	c.(2755-2757)GAT>AAT	p.D919N	ADAMTS9_uc011bfo.1_Missense_Mutation_p.D891N|ADAMTS9_uc003dmh.1_Missense_Mutation_p.D748N|ADAMTS9_uc003dmk.1_Missense_Mutation_p.D919N	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	919	TSP type-1 2.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGCAGCCGATCGCATCTTTGA	0.463													14	31					0	0	0	0	T	64606848	T	T	64606848	3	4	37	1	0	0	0	0	1	0	0	0	273	884	31	1	3136	1	ADAMTS9	3	64606848	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08		64606848	133415582	16	7860											
STK32B	55351	broad.mit.edu	37	chr4	5170125	5170125	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaggttcggaatgttttcCgggagctgcagatcatgcaa	10	11	13	7	2	1	2	1	1	0	1	3	4	2	4	1	3	3	5	1	3	2	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr4:5170125C>T	uc003gih.1	+	3	272	c.208C>T	c.(208-210)CGG>TGG	p.R70W	STK32B_uc010ida.1_Missense_Mutation_p.R23W	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	70	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GAATGTTTTCCGGGAGCTGCA	0.537													18	40					0	0	0	0	T	5170125	T	T	5170125	3	4	37	1	0	0	0	0	1	0	0	0	15364	643	23	1	218	1	STK32B	4	5170125	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08		5170125	185984151	17	7861											
CNGA1	1259	broad.mit.edu	37	chr4	47939397	47939397	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacaaagacatactcagaatCcctcacgggagggggtgttt	12	8	11	10	1	2	2	2	0	0	2	3	3	3	3	1	3	1	1	1	3	3	2			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr4:47939397C>T	uc003gxt.3	-	11	1380	c.1114G>A	c.(1114-1116)GAT>AAT	p.D372N	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Missense_Mutation_p.D441N	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	372	Cytoplasmic (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						TACTCAGAATCCCTCACGGGA	0.418													133	176					0	0	0	0	T	47939397	T	T	47939397	3	4	37	1	0	0	0	0	1	0	0	0	3611	855	30	2	962	2	CNGA1	4	47939397	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08	42769272	47939397	143214879	18	7862											
CDH10	1008	broad.mit.edu	37	chr5	24537764	24537764	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttgagtgatccatctcctTtatcttggtctgaatgtagc	8	17	8	8	0	3	3	0	3	3	0	5	3	4	3	2	1	1	1	2	1	3	5			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr5:24537764T>C	uc003jgr.1	-	3	583	c.251A>G	c.(250-252)AAA>AGA	p.K84R	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	84	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCCATCTCCTTTATCTTGGTC	0.363										HNSCC(23;0.051)			5	91					0	0	0	0	C	24537764	C	C	24537764	3	2	37	1	0	0	0	0	1	0	0	0	3111	1841	64	5	2155	5	CDH10	5	24537764	Missense_Mutation	SNP	T	TCGA-CN-4725-01A-01D-1434-08		24537764	156377496	19	7863											
VCAN	1462	broad.mit.edu	37	chr5	82816466	82816466	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtactacaaaatatgatGaaaatattacaacagtgctt	18	11	6	6	0	0	2	0	2	0	0	0	2	0	2	0	1	5	2	0	1	10	6			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr5:82816466G>A	uc003kii.3	+	7	2697	c.2341G>A	c.(2341-2343)GAA>AAA	p.E781K	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.E781K|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	781	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAAATATGATGAAAATATTAC	0.383													34	62					0	0	0	0	A	82816466	A	A	82816466	3	1	37	1	0	0	0	0	1	0	0	0	17206	1291	45	2	2363	2	VCAN	5	82816466	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	58278702	82816466	98098794	20	7864											
HIST1H1E	3008	broad.mit.edu	37	chr6	26157170	26157170	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccaagccaaaaaaggcGcccaagagcccagcgaaggc	15	0	12	14	2	0	1	0	0	0	1	0	2	0	1	4	2	4	1	4	2	6	0			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr6:26157170G>T	uc003ngq.2	+	1	612	c.552G>T	c.(550-552)GCG>GCT	p.A184A	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	184					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						CAAAAAAGGCGCCCAAGAGCC	0.567													6	28					0.00198382	0.00205223	1	0	T	26157170	T	T	26157170	2	4	37	1	0	0	0	0	0	0	0	1	7165	1074	38	3		3	HIST1H1E	6	26157170	Silent	SNP	G	TCGA-CN-4725-01A-01D-1434-08		26157170	144957897	21	7865											
OR2J2	26707	broad.mit.edu	37	chr6	29141855	29141855	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccacttgttggttgcggCttcttgggtaattggtttta	4	18	12	7	1	1	0	0	0	1	0	1	0	1	0	1	4	2	5	1	4	2	9			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr6:29141855C>A	uc011dlm.1	+	1	545	c.443C>A	c.(442-444)GCT>GAT	p.A148D		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTGGTTGCGGCTTCTTGGGTA	0.458													213	239					2.6979e-105	3.15339e-105	1	0	A	29141855	A	A	29141855	3	1	37	1	0	0	0	0	1	0	0	0	11057	797	28	4	445	4	OR2J2	6	29141855	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08	2984685	29141855	141973212	22	7866											
RING1	6015	broad.mit.edu	37	chr6	33177826	33177826	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcccatcaagaccgagtgcTtatccgcctgagccgcctgc	7	7	11	16	3	1	2	1	1	0	1	2	3	2	2	6	1	3	1	6	1	2	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr6:33177826T>G	uc003odk.2	+	4	568	c.374T>G	c.(373-375)CTT>CGT	p.L125R	RING1_uc011dqx.1_Missense_Mutation_p.L125R|RING1_uc003odl.2_Missense_Mutation_p.L96R	NM_002931	NP_002922	Q06587	RING1_HUMAN	ring finger protein 1	125	Necessary for transcriptional repression (By similarity).				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GACCGAGTGCTTATCCGCCTG	0.582													10	49					0	0	0	0	G	33177826	G	G	33177826	3	3	37	1	0	0	0	0	1	0	0	0	13439	1609	56	5	384	5	RING1	6	33177826	Missense_Mutation	SNP	T	TCGA-CN-4725-01A-01D-1434-08	4035971	33177826	137937241	23	7867											
MED23	9439	broad.mit.edu	37	chr6	131917292	131917292	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggccctcaaaatacaacttCtctggatatttctgtggaat	12	13	7	9	0	3	0	1	0	2	0	4	2	3	2	1	3	2	0	1	3	6	4			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr6:131917292C>T	uc003qcs.1	-	22	2964	c.2790G>A	c.(2788-2790)GAG>GAA	p.E930E	MED23_uc003qcq.2_Silent_p.E936E|MED23_uc003qcr.1_5'Flank|MED23_uc011eca.1_Silent_p.E571E	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	930					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		AATACAACTTCTCTGGATATT	0.378													19	96					0	0	0	0	T	131917292	T	T	131917292	2	4	37	1	0	0	0	0	0	0	0	1	9494	912	32	2		2	MED23	6	131917292	Silent	SNP	C	TCGA-CN-4725-01A-01D-1434-08	98739466	131917292	39197775	24	7868											
CCDC126	90693	broad.mit.edu	37	chr7	23682617	23682617	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgattggtgaagctggagaaCaaagttgactatattgttgt	12	13	12	4	1	0	3	0	2	0	1	0	5	0	3	0	2	2	3	0	2	5	6			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr7:23682617C>G	uc003swl.2	+	4	763	c.306C>G	c.(304-306)AAC>AAG	p.N102K	CCDC126_uc003swm.2_Missense_Mutation_p.N102K|CCDC126_uc003swn.2_Missense_Mutation_p.N102K	NM_138771	NP_620126	Q96EE4	CC126_HUMAN	coiled-coil domain containing 126 precursor	102						extracellular region				ovary(1)|skin(1)	2						AGCTGGAGAACAAAGTTGACT	0.393													4	121					0	0	0	0	G	23682617	G	G	23682617	3	3	37	1	0	0	0	0	1	0	0	0	2774	477	17	4	312	4	CCDC126	7	23682617	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08		23682617	135456046	25	7869											
STYXL1	51657	broad.mit.edu	37	chr7	75633097	75633097	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatgaagtgacacatgtggcGtaagaagggaagaatctggg	15	7	15	4	1	1	4	0	2	1	2	1	5	1	5	0	3	0	1	0	3	6	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr7:75633097G>A	uc003uej.3	-	7	849	c.676C>T	c.(676-678)CGC>TGC	p.R226C	STYXL1_uc003uef.2_Missense_Mutation_p.R32C|STYXL1_uc011kgf.1_Missense_Mutation_p.R88C|STYXL1_uc011kgg.1_Missense_Mutation_p.R78C|STYXL1_uc003ueh.2_Missense_Mutation_p.R88C|STYXL1_uc003uek.3_Missense_Mutation_p.R130C|STYXL1_uc003uel.2_Missense_Mutation_p.R226C|STYXL1_uc003uem.2_Missense_Mutation_p.R226C|STYXL1_uc010ldg.1_RNA|STYXL1_uc010ldh.1_Missense_Mutation_p.R226C|STYXL1_uc003uen.1_Missense_Mutation_p.R226C	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	226	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						CACATGTGGCGTAAGAAGGGA	0.557													23	80					0	0	0	0	A	75633097	A	A	75633097	3	1	37	1	0	0	0	0	1	0	0	0	15427	1145	40	1	277	1	STYXL1	7	75633097	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	51950480	75633097	83505566	26	7870											
PCLO	27445	broad.mit.edu	37	chr7	82785121	82785121	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctgtttagtctgaggcctgGatgcatctcgttgaagtggc	6	13	13	9	1	2	2	0	2	2	0	3	3	2	3	2	3	1	3	2	3	2	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr7:82785121G>A	uc003uhx.2	-	2	1125	c.836C>T	c.(835-837)TCC>TTC	p.S279F	PCLO_uc003uhv.2_Missense_Mutation_p.S279F	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	279	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGAGGCCTGGATGCATCTCG	0.478													50	64					0	0	0	0	A	82785121	A	A	82785121	3	1	37	1	0	0	0	0	1	0	0	0	11637	1174	41	2	14705	2	PCLO	7	82785121	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	7152024	82785121	76353542	27	7871											
ZKSCAN5	23660	broad.mit.edu	37	chr7	99128811	99128811	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagcagacatggaactaTctggaaaaacccaaagaaat	20	5	8	8	0	1	3	0	0	1	3	1	5	1	5	1	2	3	1	1	2	7	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr7:99128811T>G	uc003uqv.2	+	7	1583	c.1459T>G	c.(1459-1461)TCT>GCT	p.S487A	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.S487A|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.S487A|ZKSCAN5_uc003uqx.2_Missense_Mutation_p.S414A|ZKSCAN5_uc003uqy.2_Missense_Mutation_p.S223A	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	487					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CATGGAACTATCTGGAAAAAC	0.348													111	219					0	0	0	0	G	99128811	G	G	99128811	3	3	37	1	0	0	0	0	1	0	0	0	17757	1435	50	5	1481	5	ZKSCAN5	7	99128811	Missense_Mutation	SNP	T	TCGA-CN-4725-01A-01D-1434-08	16343690	99128811	60009852	28	7872											
ARHGEF35	445328	broad.mit.edu	37	chr7	143884371	143884371	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctgcccgctgactgggAcccctttctcctttatacca	5	12	6	18	1	1	1	0	1	1	0	3	2	2	2	7	1	2	1	7	1	2	4			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr7:143884371A>G	uc003wdz.1	-	2	1224	c.1106T>C	c.(1105-1107)GTG>GCG	p.V369A		NM_001003702	NP_001003702	A5YM69	ARG35_HUMAN	Rho guanine nucleotide exchange factor (GEF)	369	Glu-rich.										0						GCTGACTGGGACCCCTTTCTC	0.537													4	95					0	0	0	0	G	143884371	G	G	143884371	3	3	37	1	0	0	0	0	1	0	0	0	905	275	10	5	352	5	ARHGEF35	7	143884371	Missense_Mutation	SNP	A	TCGA-CN-4725-01A-01D-1434-08	44755560	143884371	15254292	29	7873											
ST3GAL1	6482	broad.mit.edu	37	chr8	134474117	134474117	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggcagggggagggtggcataCctcatcgcagacatgcattg	9	7	16	9	1	1	1	1	0	0	1	2	2	1	2	1	5	2	4	1	5	1	2			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr8:134474117C>A	uc003yuk.2	-	9	1678	c.849_splice	c.e9+1	p.E283_splice	ST3GAL1_uc003yum.2_Splice_Site_p.E283_splice	NM_173344	NP_775479	Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			GGGTGGCATACCTCATCGCAG	0.597													99	164					1.9358e-47	2.15089e-47	1	0	A	134474117	A	A	134474117	5	1	37	1	0	0	0	0	0	0	1	0	15280	521	18	4	180	4	ST3GAL1	8	134474117	Splice_Site	SNP	C	TCGA-CN-4725-01A-01D-1434-08		134474117	11889905	30	7874											
APBA1	320	broad.mit.edu	37	chr9	72055946	72055946	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctgaaaccgagctggtagCgaaggtctggtcttctgatt	8	11	13	9	3	3	2	0	2	3	0	3	4	3	2	1	3	3	3	1	3	3	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr9:72055946C>G	uc004ahh.2	-	11	2543	c.2267G>C	c.(2266-2268)CGC>CCC	p.R756P		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	756	PDZ 2.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GAGCTGGTAGCGAAGGTCTGG	0.443													32	234					0	0	0	0	G	72055946	G	G	72055946	3	3	37	1	0	0	0	0	1	0	0	0	756	768	27	3	258	3	APBA1	9	72055946	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08		72055946	69157485	31	7875											
SPTAN1	6709	broad.mit.edu	37	chr9	131346592	131346592	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcatcaccattcaggcccGccagttccaagatgctggcc	8	8	10	15	1	2	1	2	0	0	1	3	1	3	1	5	3	1	3	5	3	1	2	rs146412583		TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr9:131346592G>A	uc004bvl.3	+	17	2338	c.2225G>A	c.(2224-2226)CGC>CAC	p.R742H	SPTAN1_uc011mbg.1_Missense_Mutation_p.R742H|SPTAN1_uc011mbh.1_Missense_Mutation_p.R754H|SPTAN1_uc004bvm.3_Missense_Mutation_p.R742H|SPTAN1_uc004bvn.3_Missense_Mutation_p.R742H	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	742	Spectrin 8.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ATTCAGGCCCGCCAGTTCCAA	0.483													4	91					0	0	0	0	A	131346592	A	A	131346592	3	1	37	1	0	0	0	0	1	0	0	0	15183	1087	38	1	2287	1	SPTAN1	9	131346592	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	59290646	131346592	9866839	32	7876											
TTF1	7270	broad.mit.edu	37	chr9	135273709	135273709	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacttgccaaatttaatagcGacacctagaattgggaagga	16	9	9	7	1	0	1	0	0	0	1	0	4	0	3	2	2	3	0	2	2	7	6			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr9:135273709G>A	uc004cbl.2	-	4	1648	c.1596C>T	c.(1594-1596)GTC>GTT	p.V532V	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Silent_p.V17V	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	532					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ATTTAATAGCGACACCTAGAA	0.393													33	32					0	0	0	0	A	135273709	A	A	135273709	2	1	37	1	0	0	0	0	0	0	0	1	16786	1045	37	1		1	TTF1	9	135273709	Silent	SNP	G	TCGA-CN-4725-01A-01D-1434-08	3927117	135273709	5939722	33	7877											
SEC16A	9919	broad.mit.edu	37	chr9	139369094	139369094	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taaggtaaagtctagggctcCgtaagtgtcttcctgatgac	10	12	11	8	1	2	2	0	2	2	0	4	2	4	2	2	2	0	3	2	2	5	5			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr9:139369094C>T	uc004chx.2	-	3	3283	c.2974G>A	c.(2974-2976)GGA>AGA	p.G992R	SEC16A_uc004chv.3_Intron|SEC16A_uc004chw.2_Missense_Mutation_p.G992R|SEC16A_uc010nbn.2_Missense_Mutation_p.G992R|SEC16A_uc010nbo.1_Missense_Mutation_p.G992R	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	814					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		TCTAGGGCTCCGTAAGTGTCT	0.502													19	34					0	0	0	0	T	139369094	T	T	139369094	3	4	37	1	0	0	0	0	1	0	0	0	14051	661	23	1	4219	1	SEC16A	9	139369094	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08	4095385	139369094	1844337	34	7878											
MAN1B1	11253	broad.mit.edu	37	chr9	139995566	139995566	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggggggctcctgagtgcCtaccacctgtctggggacag	5	8	16	12	0	1	1	0	1	1	0	2	2	2	2	4	5	2	1	4	5	1	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr9:139995566C>G	uc004cld.2	+	7	1061	c.1026C>G	c.(1024-1026)GCC>GCG	p.A342A	MAN1B1_uc004clc.2_Silent_p.A243A|MAN1B1_uc011meo.1_Silent_p.A243A|MAN1B1_uc011mep.1_Silent_p.A342A|MAN1B1_uc010ncc.2_RNA|MAN1B1_uc004clf.1_5'Flank	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	342	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		TCCTGAGTGCCTACCACCTGT	0.552													60	117					0	0	0	0	G	139995566	G	G	139995566	2	3	37	1	0	0	0	0	0	0	0	1	9265	668	24	4		4	MAN1B1	9	139995566	Silent	SNP	C	TCGA-CN-4725-01A-01D-1434-08	626472	139995566	1217865	35	7879											
PDZD8	118987	broad.mit.edu	37	chr10	119100522	119100522	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taacaacgtaactttaagacGgccttcagtaagtgcccatt	13	11	7	10	2	1	1	1	0	0	1	1	1	1	1	2	1	4	2	2	1	5	7			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr10:119100522G>A	uc001lde.1	-	2	1163	c.964C>T	c.(964-966)CGT>TGT	p.R322C		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	322					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		ACTTTAAGACGGCCTTCAGTA	0.378													3	75					0	0	0	0	A	119100522	A	A	119100522	3	1	37	1	0	0	0	0	1	0	0	0	11759	1116	39	1	2516	1	PDZD8	10	119100522	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08		119100522	16434225	36	7880											
GPR26	2849	broad.mit.edu	37	chr10	125426383	125426383	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggcttccaccagctgtacGcctcgtgcacgctgtgcagc	5	9	11	16	4	0	0	0	0	0	0	3	0	1	0	3	1	5	6	3	1	1	2			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr10:125426383G>A	uc001lhh.2	+	1	513	c.460G>A	c.(460-462)GCC>ACC	p.A154T		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	154	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				CCAGCTGTACGCCTCGTGCAC	0.701													8	14					0	0	0	0	A	125426383	A	A	125426383	3	1	37	1	0	0	0	0	1	0	0	0	6722	1087	38	1	462	1	GPR26	10	125426383	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	6325861	125426383	10108364	37	7881											
OR8J3	81168	broad.mit.edu	37	chr11	55904719	55904719	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagagaatatacaaggtgaaAccacaatagctgtagaaaag	20	6	9	6	0	0	3	0	1	0	2	0	4	0	3	1	1	3	2	1	1	10	4			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr11:55904719A>T	uc010riz.1	-	1	476	c.476T>A	c.(475-477)GTT>GAT	p.V159D		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					ACAAGGTGAAACCACAATAGC	0.423													5	163					0	0	0	0	T	55904719	T	T	55904719	3	4	37	1	0	0	0	0	1	0	0	0	11296	43	2	5	473	5	OR8J3	11	55904719	Missense_Mutation	SNP	A	TCGA-CN-4725-01A-01D-1434-08		55904719	79101797	38	7882											
OR9G9	504191	broad.mit.edu	37	chr11	56467698	56467701	+	5'Flank	DEL	TGAT	-	-																															gaatacataattgcaaagccTgattgttgcaaaatgaagac																								rs33975577		TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr11:56467698_56467701delTGAT	uc010rjn.1	+							NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTGCAAAGCCTGATTGTTGCAAAA	0.279													---	---	---								-	56467701	-	-	56467698	6	5	37	0	1	1	0	1	0	0	0	0	11306	1595	55	0		0	OR9G9	11	56467698	5'Flank	DEL	TGAT	TCGA-CN-4725-01A-01D-1434-08	562979	56467698	78538818	39	7883											
ZFP91	80829	broad.mit.edu	37	chr11	58384695	58384695	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatctgtggatttacttgtcGacaaaaggcatctcttaatt	11	15	8	7	1	2	0	0	0	2	0	4	3	2	1	0	2	1	1	0	2	4	5			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr11:58384695G>T	uc001nmx.3	+	11	1397	c.1229G>T	c.(1228-1230)CGA>CTA	p.R410L	ZFP91_uc001nmy.3_Missense_Mutation_p.R409L|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	410	C2H2-type 4.				activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				TTTACTTGTCGACAAAAGGCA	0.398													54	121					5.66675e-16	6.07152e-16	1	0	T	58384695	T	T	58384695	3	4	37	1	0	0	0	0	1	0	0	0	17722	1058	37	3	1271	3	ZFP91	11	58384695	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	1916997	58384695	76621821	40	7884											
SCYL1	57410	broad.mit.edu	37	chr11	65298219	65298219	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgctgaccgccttcgagttCggcaatgctggggccgttgt	4	11	14	12	4	0	1	0	1	0	0	2	2	0	1	3	3	2	5	3	3	1	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr11:65298219C>T	uc001oea.1	+	7	1046	c.969C>T	c.(967-969)TTC>TTT	p.F323F	SCYL1_uc009yqk.2_Silent_p.F323F|SCYL1_uc001oeb.1_Silent_p.F323F|SCYL1_uc001oec.1_Silent_p.F323F|SCYL1_uc001oed.1_Silent_p.F180F|SCYL1_uc001oee.1_5'UTR	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	323					regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						CCTTCGAGTTCGGCAATGCTG	0.587													30	149					0	0	0	0	T	65298219	T	T	65298219	2	4	37	1	0	0	0	0	0	0	0	1	14012	883	31	1		1	SCYL1	11	65298219	Silent	SNP	C	TCGA-CN-4725-01A-01D-1434-08	6913524	65298219	69708297	41	7885											
DYNC2H1	79659	broad.mit.edu	37	chr11	102987416	102987416	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatcattatcctgagtcaCgaatgttgcatctcttagac	11	14	7	9	1	3	3	2	2	1	1	5	4	4	3	1	0	1	2	1	0	3	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr11:102987416C>T	uc001pho.2	+	5	883	c.739C>T	c.(739-741)CGA>TGA	p.R247*	DYNC2H1_uc001phn.1_Nonsense_Mutation_p.R247*|DYNC2H1_uc009yxe.1_Nonsense_Mutation_p.R247*	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	247	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TCCTGAGTCACGAATGTTGCA	0.348													25	210					0	0	0	0	T	102987416	T	T	102987416	4	4	37	1	0	0	0	0	0	1	0	0	4868	528	19	1	757	1	DYNC2H1	11	102987416	Nonsense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08	37689197	102987416	32019100	42	7886											
PRB3	5544	broad.mit.edu	37	chr12	11420570	11420570	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttgtgggggtggtccttCtggctttcccggacgaggtg	2	13	16	10	2	1	0	0	0	1	0	4	2	4	1	3	6	0	1	3	6	0	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr12:11420570C>A	uc001qzs.2	-	3	651	c.613G>T	c.(613-615)GAA>TAA	p.E205*	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	205	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|8.|Pro-rich.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGTGGTCCTTCTGGCTTTCCC	0.632													56	326					2.76928e-52	3.15488e-52	1	0	A	11420570	A	A	11420570	4	1	37	1	0	0	0	0	0	1	0	0	12506	922	32	2	324	2	PRB3	12	11420570	Nonsense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08		11420570	122431325	43	7887											
DENND5B	160518	broad.mit.edu	37	chr12	31586167	31586167	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgcgctgtgcagtggcactCcgacttacccagcgactgaa	8	8	11	14	3	0	1	0	1	0	0	1	3	1	1	2	1	4	3	2	1	2	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr12:31586167C>G	uc001rki.1	-	8	2214	c.2028G>C	c.(2026-2028)CGG>CGC	p.R676R	DENND5B_uc001rkh.1_Silent_p.R711R|DENND5B_uc009zjq.1_Intron|DENND5B_uc001rkj.2_Silent_p.R698R	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	676						integral to membrane				ovary(1)|central_nervous_system(1)	2						CAGTGGCACTCCGACTTACCC	0.448													5	274					0	0	0	0	G	31586167	G	G	31586167	2	3	37	1	0	0	0	0	0	0	0	1	4459	842	30	2		2	DENND5B	12	31586167	Silent	SNP	C	TCGA-CN-4725-01A-01D-1434-08	20165597	31586167	102265728	44	7888											
KDELC1	79070	broad.mit.edu	37	chr13	103441563	103441563	+	Nonsense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccatcgatatttatttgAtacttatgctgcaaaacaat	13	15	6	7	1	0	1	0	1	0	0	1	2	0	1	1	0	5	2	1	0	7	6			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr13:103441563A>C	uc001vpq.3	-	7	1476	c.1092T>G	c.(1090-1092)TAT>TAG	p.Y364*	KDELC1_uc001vpr.3_Nonsense_Mutation_p.Y145*	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	364						endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TATTTATTTGATACTTATGCT	0.393													4	72					0	0	0	0	C	103441563	C	C	103441563	4	2	37	1	0	0	0	0	0	1	0	0	8156	340	12	5	432	5	KDELC1	13	103441563	Nonsense_Mutation	SNP	A	TCGA-CN-4725-01A-01D-1434-08		103441563	11728315	45	7889											
C14orf37	145407	broad.mit.edu	37	chr14	58605804	58605804	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctgggtttctttgttaatCgagaatgctttatttaatga	9	18	10	4	1	1	2	0	1	1	1	2	3	1	2	0	2	1	4	0	2	4	7			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr14:58605804C>T	uc001xdc.2	-	2	384	c.273G>A	c.(271-273)TCG>TCA	p.S91S	C14orf37_uc010tro.1_Silent_p.S129S|C14orf37_uc001xdd.2_Silent_p.S91S|C14orf37_uc001xde.2_Silent_p.S91S	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	91	Extracellular (Potential).					integral to membrane	binding				0						CTTTGTTAATCGAGAATGCTT	0.488													80	143					0	0	0	0	T	58605804	T	T	58605804	2	4	37	1	0	0	0	0	0	0	0	1	1777	871	31	1		1	C14orf37	14	58605804	Silent	SNP	C	TCGA-CN-4725-01A-01D-1434-08		58605804	48743736	46	7890											
LTBP2	4053	broad.mit.edu	37	chr14	74968148	74968148	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaattctgcacttacctacGcaggccatgtgggccgcatc	9	9	10	13	2	1	1	0	0	1	1	2	1	1	1	3	2	3	3	3	2	3	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr14:74968148G>A	uc001xqa.2	-	35	5703	c.5316C>T	c.(5314-5316)TGC>TGT	p.C1772C		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1772	EGF-like 19; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		ACTTACCTACGCAGGCCATGT	0.607											OREG0022805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	100	165					0	0	0	0	A	74968148	A	A	74968148	2	1	37	1	0	0	0	0	0	0	0	1	9124	1079	38	1		1	LTBP2	14	74968148	Silent	SNP	G	TCGA-CN-4725-01A-01D-1434-08	16362344	74968148	32381392	47	7891											
OR4M2	390538	broad.mit.edu	37	chr15	22369030	22369030	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggctctctcctggaggggggGcttcattcattctatcatac	6	13	11	11	0	5	0	3	0	2	0	7	1	6	1	1	5	1	2	1	5	2	5			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr15:22369030G>C	uc010tzu.1	+	1	455	c.455G>C	c.(454-456)GGC>GCC	p.G152A	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGGAGGGGGGGCTTCATTCAT	0.502													73	382					0	0	0	0	C	22369030	C	C	22369030	3	2	37	1	0	0	0	0	1	0	0	0	11130	1203	42	4	457	4	OR4M2	15	22369030	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08		22369030	80162362	48	7892											
RTF1	23168	broad.mit.edu	37	chr15	41769670	41769670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacagttacatcaaccagcGgaaccgggagtggaacattg	13	6	11	11	2	1	0	1	0	0	0	1	3	1	3	3	3	5	1	3	3	4	2			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr15:41769670G>A	uc001zny.2	+	14	1709	c.1697G>A	c.(1696-1698)CGG>CAG	p.R566Q		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	566					histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		ATCAACCAGCGGAACCGGGAG	0.453													36	115					0	0	0	0	A	41769670	A	A	41769670	3	1	37	1	0	0	0	0	1	0	0	0	13786	1116	39	1	1751	1	RTF1	15	41769670	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	19400640	41769670	60761722	49	7893											
THAP10	56906	broad.mit.edu	37	chr15	71175199	71175199	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgaagtgacagtattagatgGattatcagcatggggttggg	11	12	15	3	0	1	3	1	2	0	1	1	4	1	4	0	4	1	3	0	4	4	4			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr15:71175199G>C	uc002asv.2	-	2	620	c.478C>G	c.(478-480)CCA>GCA	p.P160A	LRRC49_uc002asu.2_Intron	NM_020147	NP_064532	Q9P2Z0	THA10_HUMAN	THAP domain containing 10	160							DNA binding|metal ion binding			ovary(1)|skin(1)	2						GTATTAGATGGATTATCAGCA	0.393													29	117					0	0	0	0	C	71175199	C	C	71175199	3	2	37	1	0	0	0	0	1	0	0	0	15908	1174	41	2	303	2	THAP10	15	71175199	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	29405529	71175199	31356193	50	7894											
SLC28A1	9154	broad.mit.edu	37	chr15	85447466	85447466	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctgctcaaagcatcattgCgcagtgagtgctagttgtgg	8	11	13	9	1	2	1	2	1	0	0	2	1	2	1	1	1	4	5	1	1	2	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr15:85447466C>T	uc002blg.2	+	7	802	c.600C>T	c.(598-600)TGC>TGT	p.C200C	SLC28A1_uc010upd.1_Silent_p.C122C|SLC28A1_uc010bnb.2_Silent_p.C200C|SLC28A1_uc010upe.1_Silent_p.C200C|SLC28A1_uc010upf.1_Silent_p.C200C|SLC28A1_uc010upg.1_Silent_p.C200C	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	200					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCATCATTGCGCAGTGAGTG	0.587													83	60					0	0	0	0	T	85447466	T	T	85447466	2	4	37	1	0	0	0	0	0	0	0	1	14595	776	27	1		1	SLC28A1	15	85447466	Silent	SNP	C	TCGA-CN-4725-01A-01D-1434-08	14272267	85447466	17083926	51	7895											
KLHL25	64410	broad.mit.edu	37	chr15	86311486	86311486	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcatgtccccaatccgcGtccactggttggtctcacag	7	10	9	15	2	2	0	2	0	1	0	6	0	5	0	4	2	0	1	4	2	1	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr15:86311486G>A	uc002bly.2	-	2	1759	c.1556C>T	c.(1555-1557)ACG>ATG	p.T519M		NM_022480	NP_071925	Q9H0H3	ENC2_HUMAN	BTB/POZ KELCH domain protein	519	Kelch 5.					cytoplasm				ovary(2)	2						CCCAATCCGCGTCCACTGGTT	0.612													29	91					0	0	0	0	A	86311486	A	A	86311486	3	1	37	1	0	0	0	0	1	0	0	0	8419	1145	40	1	217	1	KLHL25	15	86311486	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	864020	86311486	16219906	52	7896											
ZG16B	124220	broad.mit.edu	37	chr16	2880459	2880459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccatgctgctgctgctcaCgcttgccctcctggggggcc	2	9	14	16	1	1	0	1	0	0	0	2	0	2	0	4	4	5	5	4	4	0	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr16:2880459C>T	uc002cru.2	+	2	201	c.125C>T	c.(124-126)ACG>ATG	p.T42M		NM_145252	NP_660295	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16 homolog B precursor	42	Poly-Leu.					extracellular region	sugar binding			ovary(1)	1						CTGCTGCTCACGCTTGCCCTC	0.662													14	14					0	0	0	0	T	2880459	T	T	2880459	3	4	37	1	0	0	0	0	1	0	0	0	17739	536	19	1	131	1	ZG16B	16	2880459	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08		2880459	87474294	53	7897											
VASN	114990	broad.mit.edu	37	chr16	4432462	4432462	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcacccagctgcggcccaaCgccacttactccgtctgtgt	6	9	9	17	3	2	0	1	0	1	0	3	0	3	0	4	1	4	1	4	1	2	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr16:4432462C>T	uc002cwj.1	+	2	1739	c.1584C>T	c.(1582-1584)AAC>AAT	p.N528N	CORO7_uc002cwe.2_Intron|CORO7_uc002cwf.2_Intron|CORO7_uc002cwg.3_Intron|CORO7_uc002cwh.3_Intron|CORO7_uc010uxh.1_Intron|CORO7_uc010uxi.1_Intron|CORO7_uc002cwi.1_Intron|CORO7_uc010uxj.1_Intron|CORO7_uc010btp.1_Intron	NM_138440	NP_612449	Q6EMK4	VASN_HUMAN	slit-like 2 precursor	528	Fibronectin type-III.|Extracellular (Potential).					extracellular region|integral to membrane					0						TGCGGCCCAACGCCACTTACT	0.677													10	9					0	0	0	0	T	4432462	T	T	4432462	2	4	37	1	0	0	0	0	0	0	0	1	17195	535	19	1		1	VASN	16	4432462	Silent	SNP	C	TCGA-CN-4725-01A-01D-1434-08	1552003	4432462	85922291	54	7898											
CLEC16A	23274	broad.mit.edu	37	chr16	11114077	11114077	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatggtgatcatggagcgtaGcaagctctcagagctggccg	9	8	15	9	2	2	2	2	1	1	1	3	4	2	3	1	3	4	4	1	3	2	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr16:11114077G>A	uc002dao.2	+	12	1561	c.1331G>A	c.(1330-1332)AGC>AAC	p.S444N	CLEC16A_uc002dan.3_Missense_Mutation_p.S426N	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	444								p.0?(1)		ovary(1)|central_nervous_system(1)	2						ATGGAGCGTAGCAAGCTCTCA	0.557													25	58					0	0	0	0	A	11114077	A	A	11114077	3	1	37	1	0	0	0	0	1	0	0	0	3515	971	34	4	1373	4	CLEC16A	16	11114077	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08	6681615	11114077	79240676	55	7899											
MYH11	4629	broad.mit.edu	37	chr16	15870006	15870006	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctctcgtctctggcttggCgaattgcccgtgatttttct	3	17	9	12	3	3	1	0	1	3	0	6	2	4	1	2	2	1	1	2	2	1	4			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr16:15870006C>T	uc002ddy.2	-	8	925	c.818G>A	c.(817-819)CGC>CAC	p.R273H	MYH11_uc002ddv.2_Missense_Mutation_p.R280H|MYH11_uc002ddw.2_Missense_Mutation_p.R273H|MYH11_uc002ddx.2_Missense_Mutation_p.R280H|MYH11_uc010bvg.2_Missense_Mutation_p.R105H|MYH11_uc002dea.1_5'UTR	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	273	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TCTGGCTTGGCGAATTGCCCG	0.488			T	CBFB	AML								118	232					0	0	0	0	T	15870006	T	T	15870006	3	4	37	1	0	0	0	0	1	0	0	0	10084	768	27	1	5271	1	MYH11	16	15870006	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08	4755929	15870006	74484747	56	7900											
PALB2	79728	broad.mit.edu	37	chr16	23646536	23646536	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatttttacttgcatccttaTttttatttttaaaccctttt	9	24	1	7	0	0	0	0	0	0	0	1	0	1	0	2	0	3	1	2	0	6	13			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr16:23646536T>C	uc002dlx.1	-	4	1531	c.1331A>G	c.(1330-1332)AAT>AGT	p.N444S		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	444					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		TGCATCCTTATTTTTATTTTT	0.393			F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				75	139					0	0	0	0	C	23646536	C	C	23646536	3	2	37	1	0	0	0	0	1	0	0	0	11460	1493	52	5	2269	5	PALB2	16	23646536	Missense_Mutation	SNP	T	TCGA-CN-4725-01A-01D-1434-08	7776530	23646536	66708217	57	7901											
TNRC6A	27327	broad.mit.edu	37	chr16	24834933	24834933	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagccggaccgatctcaaTcactggaatggtgctgggct	8	9	12	12	2	2	0	2	0	1	0	4	3	3	2	3	4	2	2	3	4	2	0			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr16:24834933T>A	uc002dmm.2	+	25	5808	c.5694T>A	c.(5692-5694)AAT>AAA	p.N1898K	TNRC6A_uc010bxs.2_Missense_Mutation_p.N1645K|TNRC6A_uc002dmn.2_Missense_Mutation_p.N1596K|TNRC6A_uc002dmo.2_Missense_Mutation_p.N1537K|TNRC6A_uc002dmr.2_Missense_Mutation_p.N97K	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1898	Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		CCGATCTCAATCACTGGAATG	0.622													147	287					0	0	0	0	A	24834933	A	A	24834933	3	1	37	1	0	0	0	0	1	0	0	0	16406	1432	50	5	5792	5	TNRC6A	16	24834933	Missense_Mutation	SNP	T	TCGA-CN-4725-01A-01D-1434-08	1188397	24834933	65519820	58	7902											
TP53	7157	broad.mit.edu	37	chr17	7577114	7577114	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctctcccaggacaggcaCaaacacgcacctcaaagctg	12	5	9	15	1	2	0	1	0	1	0	4	1	3	1	2	3	2	3	2	3	2	0			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr17:7577114C>A	uc002gim.2	-	8	1018	c.824G>T	c.(823-825)TGT>TTT	p.C275F	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.C275F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C143F|TP53_uc010cng.1_Missense_Mutation_p.C143F|TP53_uc002gii.1_Missense_Mutation_p.C143F|TP53_uc010cnh.1_Missense_Mutation_p.C275F|TP53_uc010cni.1_Missense_Mutation_p.C275F|TP53_uc002gij.2_Missense_Mutation_p.C275F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	275	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C275Y(44)|p.C275F(34)|p.C275G(7)|p.C275W(7)|p.0?(7)|p.C275R(6)|p.C275C(4)|p.C275fs*70(2)|p.C275fs*31(2)|p.?(2)|p.C275S(2)|p.R273_C275delRVC(1)|p.C275_A276ins10(1)|p.V274_P278del(1)|p.C275*(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.A276fs*29(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGACAGGCACAAACACGCAC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	35					6.40141e-05	6.69915e-05	1	0	A	7577114	A	A	7577114	3	1	37	1	0	0	0	0	1	0	0	0	16448	478	17	4	462	4	TP53	17	7577114	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08		7577114	73618096	59	7903											
SUPT6H	6830	broad.mit.edu	37	chr17	27017143	27017143	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actctatgacatccgggcagAgctgagctgtcgatataagg	11	9	12	9	2	1	3	0	2	1	1	3	4	2	3	1	2	2	3	1	2	3	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr17:27017143A>C	uc002hby.2	+	26	3476	c.3386A>C	c.(3385-3387)GAG>GCG	p.E1129A	SUPT6H_uc010crt.2_Missense_Mutation_p.E1129A|SUPT6H_uc002hbz.1_Missense_Mutation_p.E61A	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1129					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					ATCCGGGCAGAGCTGAGCTGT	0.522													126	143					0	0	0	0	C	27017143	C	C	27017143	3	2	37	1	0	0	0	0	1	0	0	0	15466	304	11	5	3484	5	SUPT6H	17	27017143	Missense_Mutation	SNP	A	TCGA-CN-4725-01A-01D-1434-08	19440029	27017143	54178067	60	7904											
SPOP	8405	broad.mit.edu	37	chr17	47700125	47700126	+	Frame_Shift_Ins	INS	-	CCAC	CCAC																															accaactctcagctacggggINSccactcgacatttctgccgg																										TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr17:47700125_47700126insCCAC	uc010dbk.2	-	3	679_680	c.47_48insGTGG	c.(46-48)GGCfs	p.G16fs	SPOP_uc002ipb.2_Frame_Shift_Ins_p.G16fs|SPOP_uc002ipc.2_Frame_Shift_Ins_p.G16fs|SPOP_uc002ipd.2_Frame_Shift_Ins_p.G16fs|SPOP_uc002ipe.2_Frame_Shift_Ins_p.G16fs|SPOP_uc002ipf.2_Frame_Shift_Ins_p.G16fs|SPOP_uc002ipg.2_Frame_Shift_Ins_p.G16fs|SPOP_uc010wlx.1_RNA	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein	16					mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						CAGCTACGGGGCCACTCGACAT	0.495										Prostate(2;0.17)			---	---	---								CCAC	47700126	CCAC	CCAC	47700125	7	5	37	1	0	1	1	0	0	0	0	0	15150	1190	42	0	1112	0	SPOP	17	47700125	Frame_Shift_Ins	INS	-	TCGA-CN-4725-01A-01D-1434-08	20682982	47700125	33495085	61	7905											
TUBB6	84617	broad.mit.edu	37	chr18	12325401	12325401	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agacctactgcatcgacaacGaggcgctctatgacatctgc	11	8	9	13	3	2	2	0	1	2	1	3	4	2	2	1	1	4	2	1	1	3	2			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr18:12325401G>A	uc002kqw.2	+	4	658	c.613G>A	c.(613-615)GAG>AAG	p.E205K	TUBB6_uc002kqv.2_Missense_Mutation_p.E133K|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Missense_Mutation_p.E168K|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	205					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		CATCGACAACGAGGCGCTCTA	0.602													38	208					0	0	0	0	A	12325401	A	A	12325401	3	1	37	1	0	0	0	0	1	0	0	0	16828	1059	37	1	627	1	TUBB6	18	12325401	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08		12325401	65751847	62	7906											
ZNF791	163049	broad.mit.edu	37	chr19	12740051	12740051	+	Frame_Shift_Del	DEL	C	-	-																															tgtccacatccttaaaaaaaCatatgagaatgcacaatcga																										TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr19:12740051delC	uc002mua.2	+	4	1870	c.1708delC	c.(1708-1710)CATfs	p.H570fs	ZNF791_uc010xml.1_Frame_Shift_Del_p.H538fs|ZNF791_uc010dyu.1_Frame_Shift_Del_p.H461fs|ZNF791_uc010xmm.1_Frame_Shift_Del_p.H461fs	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	570	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTTAAAAAAACATATGAGAAT	0.338													---	---	---								-	12740051	-	-	12740051	7	5	37	1	0	1	0	1	0	0	0	0	18230	478	17	0	1722	0	ZNF791	19	12740051	Frame_Shift_Del	DEL	C	TCGA-CN-4725-01A-01D-1434-08		12740051	46388932	63	7907											
UPF1	5976	broad.mit.edu	37	chr19	18968194	18968194	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaagaaggcggccaaggcCgggctgtcacagtcgctctt	8	7	14	12	3	2	1	1	0	1	1	3	1	2	1	2	4	1	3	2	4	3	1			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr19:18968194C>T	uc002nkg.2	+	15	2342	c.2067C>T	c.(2065-2067)GCC>GCT	p.A689A	UPF1_uc002nkf.2_Silent_p.A678A|UPF1_uc002nkh.2_5'Flank	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	689					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CGGCCAAGGCCGGGCTGTCAC	0.647													32	105					0	0	0	0	T	18968194	T	T	18968194	2	4	37	1	0	0	0	0	0	0	0	1	17071	639	23	1		1	UPF1	19	18968194	Silent	SNP	C	TCGA-CN-4725-01A-01D-1434-08	6228143	18968194	40160789	64	7908											
ZNF737	100129842	broad.mit.edu	37	chr19	20727463	20727463	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggggcacttaaagccttTgccacattcttcacatttgt	10	13	8	10	0	2	1	1	0	1	1	2	1	2	1	2	2	2	1	2	2	2	5	rs10411329	by1000genomes	TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr19:20727463T>C	uc002npa.2	-	4	1726	c.1546A>G	c.(1546-1548)AAA>GAA	p.K516E		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	516					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TTAAAGCCTTTGCCACATTCT	0.403													3	55					0	0	0	0	C	20727463	C	C	20727463	3	2	37	1	0	0	0	0	1	0	0	0	18193	1821	63	5	68	5	ZNF737	19	20727463	Missense_Mutation	SNP	T	TCGA-CN-4725-01A-01D-1434-08	1759269	20727463	38401520	65	7909											
MMP9	4318	broad.mit.edu	37	chr20	44641091	44641091	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtttgttcctcgtggcggcGcatgagttcggccacgcgct	4	11	14	12	6	0	1	0	1	0	0	3	1	1	1	2	3	0	5	2	3	0	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr20:44641091G>A	uc002xqz.2	+	8	1219	c.1200G>A	c.(1198-1200)GCG>GCA	p.A400A		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	400					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TCGTGGCGGCGCATGAGTTCG	0.652													85	81					0	0	0	0	A	44641091	A	A	44641091	2	1	37	1	0	0	0	0	0	0	0	1	9722	1074	38	1		1	MMP9	20	44641091	Silent	SNP	G	TCGA-CN-4725-01A-01D-1434-08		44641091	18384429	66	7910											
LAMA5	3911	broad.mit.edu	37	chr20	60900576	60900576	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcgcgggacacagtgttGcgcgtctccgtatgccggaa	6	9	13	13	6	1	0	0	0	1	0	4	2	2	2	3	2	2	2	3	2	2	2			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr20:60900576G>T	uc002ycq.2	-	41	5392	c.5325C>A	c.(5323-5325)CGC>CGA	p.R1775R		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1775	Laminin IV type A.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACACAGTGTTGCGCGTCTCCG	0.622													49	52					2.74695e-27	2.97862e-27	1	0	T	60900576	T	T	60900576	2	4	37	1	0	0	0	0	0	0	0	1	8649	1306	46	4		4	LAMA5	20	60900576	Silent	SNP	G	TCGA-CN-4725-01A-01D-1434-08	16259485	60900576	2124944	67	7911											
ZBTB46	140685	broad.mit.edu	37	chr20	62421367	62421367	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagagttctgtactgcaccGtccttggcagaaggcagctc	10	9	11	11	1	1	2	0	0	1	2	3	2	2	2	2	2	3	6	2	2	3	3			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr20:62421367G>A	uc002ygv.1	-	2	945	c.744C>T	c.(742-744)GAC>GAT	p.D248D	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					GTACTGCACCGTCCTTGGCAG	0.587													59	110					0	0	0	0	A	62421367	A	A	62421367	2	1	37	1	0	0	0	0	0	0	0	1	17614	1136	40	1		1	ZBTB46	20	62421367	Silent	SNP	G	TCGA-CN-4725-01A-01D-1434-08	1520791	62421367	604153	68	7912											
SIK1	150094	broad.mit.edu	37	chr21	44837482	44837482	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccggctgccggctgcgccGccgtgcaggcctgggctctg	1	7	16	17	5	1	0	0	0	1	0	2	0	2	0	5	4	3	4	5	4	0	0			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr21:44837482G>A	uc002zdf.2	-	13	2044	c.1917C>T	c.(1915-1917)GGC>GGT	p.G639G		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	639					anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						CGGCTGCGCCGCCGTGCAGGC	0.771													10	17					0	0	0	0	A	44837482	A	A	44837482	2	1	37	1	0	0	0	0	0	0	0	1	14382	1074	38	1		1	SIK1	21	44837482	Silent	SNP	G	TCGA-CN-4725-01A-01D-1434-08		44837482	3292413	69	7913											
TBC1D10A	83874	broad.mit.edu	37	chr22	30688463	30688478	+	Frame_Shift_Del	DEL	GGGGGCTGAGTCCTTC	-	-																															tcctgaggggctgagtccttGggggctgagtccttcggggg																								rs146725573	byFrequency	TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chr22:30688463_30688478delGGGGGCTGAGTCCTTC	uc011akt.1	-	11	1437_1452	c.1413_1428delGAAGGACTCAGCCCCC	c.(1411-1428)CCGAAGGACTCAGCCCCCfs	p.P471fs	GATSL3_uc003ahc.2_5'Flank|GATSL3_uc003ahe.2_5'Flank|GATSL3_uc003ahd.2_5'Flank|GATSL3_uc003ahf.2_Intron|GATSL3_uc003ahg.2_Intron|GATSL3_uc003ahh.2_Intron|GATSL3_uc010gvq.2_Intron|GATSL3_uc003ahi.2_Intron|GATSL3_uc010gvr.2_5'Flank|GATSL3_uc010gvs.2_5'Flank|TBC1D10A_uc003ahj.3_Frame_Shift_Del_p.P383fs|TBC1D10A_uc010gvu.2_Frame_Shift_Del_p.P478fs|TBC1D10A_uc003ahk.3_Frame_Shift_Del_p.P471fs	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	471_476						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CTGAGTCCTTGGGGGCTGAGTCCTTCGGGGGCACAT	0.62													---	---	---								-	30688478	-	-	30688463	7	5	37	1	0	1	0	1	0	0	0	0	15664	1335	47	0	102	0	TBC1D10A	22	30688463	Frame_Shift_Del	DEL	GGGGGCTGAGTCCTTC	TCGA-CN-4725-01A-01D-1434-08		30688463	20616103	70	7914											
MED12	9968	broad.mit.edu	37	chrX	70356303	70356303	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacacacacctgaggccccGgccccgcgcctattacctgg	7	5	9	20	3	0	1	0	1	0	0	0	1	0	1	8	3	1	0	8	3	2	2			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chrX:70356303G>A	uc004dyy.2	+	37	5397	c.5198G>A	c.(5197-5199)CGG>CAG	p.R1733Q	MED12_uc011mpq.1_Missense_Mutation_p.R1733Q|MED12_uc004dyz.2_Missense_Mutation_p.R1733Q|MED12_uc004dza.2_Missense_Mutation_p.R1580Q|MED12_uc010nla.2_Missense_Mutation_p.R359Q	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1733	Pro-rich.|Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CTGAGGCCCCGGCCCCGCGCC	0.642													14	4					0	0	0	0	A	70356303	A	A	70356303	3	1	37	1	0	0	0	0	1	0	0	0	9481	1116	39	1	5344	1	MED12	23	70356303	Missense_Mutation	SNP	G	TCGA-CN-4725-01A-01D-1434-08		70356303	84914257	71	7915											
LRCH2	57631	broad.mit.edu	37	chrX	114357668	114357668	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagttgtcgtatttgctctCgctcttcccgtaaatgttcc	6	16	8	11	3	2	0	0	0	2	0	6	1	4	0	2	0	1	6	2	0	4	6			TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chrX:114357668C>T	uc010nqe.2	-	18	1968	c.1937G>A	c.(1936-1938)CGA>CAA	p.R646Q	LRCH2_uc004epz.2_Missense_Mutation_p.R629Q	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)	646	CH.									ovary(1)	1						TATTTGCTCTCGCTCTTCCCG	0.408													14	13					0	0	0	0	T	114357668	T	T	114357668	3	4	37	1	0	0	0	0	1	0	0	0	8983	884	31	1	376	1	LRCH2	23	114357668	Missense_Mutation	SNP	C	TCGA-CN-4725-01A-01D-1434-08	44001365	114357668	40912892	72	7916											
FAM58A	92002	broad.mit.edu	37	chrX	152864477	152864478	+	Frame_Shift_Ins	INS	-	C	C																															ctggcttcgggcgccggctgINSccctccgggccccgcgctgc																										TCGA-CN-4725-01A-01D-1434-08	TCGA-CN-4725-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57ffef9d-193b-48f6-8d5b-3c2eca854d93	8a585a96-f23e-4afb-b08e-2b60962fd3bd	g.chrX:152864477_152864478insC	uc010nug.2	-	1	155_156	c.52_53insG	c.(52-54)GCAfs	p.A18fs				Q8N1B3	FA58A_HUMAN	RecName: Full=Cyclin-related protein FAM58B;	13					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGCGCCGGCTGCCCTCCGGGCC	0.782													---	---	---								C	152864478	C	C	152864477	7	5	37	1	0	1	1	0	0	0	0	0	5622	1319	46	0	711	0	FAM58A	23	152864477	Frame_Shift_Ins	INS	-	TCGA-CN-4725-01A-01D-1434-08	38506809	152864477	2406083	73	7917											
EPHA2	1969	broad.mit.edu	37	chr1	16461022	16461023	+	Frame_Shift_Ins	INS	-	A	A																															gcaggaccacaccgacagccINSacgccgccaatcaccgccaa																										TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:16461022_16461023insA	uc001aya.1	-	8	1759_1760	c.1622_1623insT	c.(1621-1623)GTGfs	p.V541fs		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	541	Helical; (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CACCGACAGCCACGCCGCCAAT	0.594													---	---	---								A	16461023	A	A	16461022	7	5	38	1	0	1	1	0	0	0	0	0	5191	581	21	0	1347	0	EPHA2	1	16461022	Frame_Shift_Ins	INS	-	TCGA-CN-4726-01A-01D-1434-08		16461022	232789599	1	7918											
RLF	6018	broad.mit.edu	37	chr1	40668129	40668129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accttcctttctgcaaatgcGaataaaacatttgttgaaat	14	14	5	8	1	1	1	0	1	1	0	2	2	2	1	2	0	3	2	2	0	5	5			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:40668129G>A	uc001cfc.3	+	5	684	c.653G>A	c.(652-654)CGA>CAA	p.R218Q		NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	218					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			CTGCAAATGCGAATAAAACAT	0.333													21	88					0	0	0	0	A	40668129	A	A	40668129	3	1	38	1	0	0	0	0	1	0	0	0	13454	1058	37	1	671	1	RLF	1	40668129	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	24207107	40668129	208582492	2	7919											
MSH4	4438	broad.mit.edu	37	chr1	76378560	76378560	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaacaagttccagaaaaGactgaagaataatcacaatt	20	8	6	7	0	1	5	1	2	0	3	2	5	2	5	1	0	1	1	1	0	8	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:76378560G>T	uc001dhd.1	+	20	2840	c.2799G>T	c.(2797-2799)AAG>AAT	p.K933N		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	933					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TTCCAGAAAAGACTGAAGAAT	0.303								MMR					9	38					1.33987e-11	1.62699e-11	1	0	T	76378560	T	T	76378560	3	4	38	1	0	0	0	0	1	0	0	0	9925	933	33	2	2877	2	MSH4	1	76378560	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	35710431	76378560	172872061	3	7920											
GBP7	388646	broad.mit.edu	37	chr1	89618020	89618020	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgtccatctaacttcagctCcagggtaaaatctcgaacag	12	10	8	11	1	3	0	1	0	2	0	6	1	5	0	2	1	3	2	2	1	4	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:89618020C>T	uc001dna.2	-	5	695	c.556G>A	c.(556-558)GAG>AAG	p.E186K	GBP2_uc001dmy.1_5'Flank	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	186						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		AACTTCAGCTCCAGGGTAAAA	0.478													6	227					0	0	0	0	T	89618020	T	T	89618020	3	4	38	1	0	0	0	0	1	0	0	0	6314	864	30	2	1388	2	GBP7	1	89618020	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	13239460	89618020	159632601	4	7921											
C1orf103	55791	broad.mit.edu	37	chr1	111495337	111495337	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gactgaagattgaactagtgGtataagatttccagaagact	15	11	10	5	0	0	6	0	2	0	4	1	7	1	6	1	1	1	1	1	1	6	5			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:111495337G>C	uc001eaa.2	-	2	425	c.169C>G	c.(169-171)CCA>GCA	p.P57A	C1orf103_uc001dzz.2_5'UTR|C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		TGAACTAGTGGTATAAGATTT	0.398													22	99					0	0	0	0	C	111495337	C	C	111495337	3	2	38	1	0	0	0	0	1	0	0	0	1986	1261	44	4	2152	4	C1orf103	1	111495337	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	21877317	111495337	137755284	5	7922											
NOTCH2	4853	broad.mit.edu	37	chr1	120510064	120510064	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggcccatttacctggcatgCacagacatgtgaagcctcca	10	8	10	13	0	0	2	0	1	0	1	1	2	1	2	4	2	3	2	4	2	2	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:120510064C>G	uc001eik.2	-	8	1701	c.1445G>C	c.(1444-1446)TGC>TCC	p.C482S	NOTCH2_uc001eil.2_Missense_Mutation_p.C482S|NOTCH2_uc001eim.3_Missense_Mutation_p.C399S	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	482	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACCTGGCATGCACAGACATGT	0.488			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				85	247					0	0	0	0	G	120510064	G	G	120510064	3	3	38	1	0	0	0	0	1	0	0	0	10602	710	25	4	6078	4	NOTCH2	1	120510064	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	9014727	120510064	128740557	6	7923											
PSMD4	5710	broad.mit.edu	37	chr1	151238835	151238835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagccagcaagagtttggccGcactgggcttcctgacctaa	9	8	11	13	1	0	2	0	1	0	1	1	2	1	2	4	2	2	4	4	2	2	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:151238835G>A	uc001exl.2	+	8	877	c.815G>A	c.(814-816)CGC>CAC	p.R272H	PSMD4_uc001exn.2_Missense_Mutation_p.R275H	NM_002810	NP_002801	P55036	PSMD4_HUMAN	proteasome 26S non-ATPase subunit 4	272					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GAGTTTGGCCGCACTGGGCTT	0.547													5	228					0	0	0	0	A	151238835	A	A	151238835	3	1	38	1	0	0	0	0	1	0	0	0	12762	1087	38	1	845	1	PSMD4	1	151238835	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	30728771	151238835	98011786	7	7924											
ZNF687	57592	broad.mit.edu	37	chr1	151260750	151260750	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccgctctccacagagccGcctgctgccccggccacctc	4	6	9	22	3	1	1	0	0	1	1	3	1	1	1	8	1	4	2	8	1	0	0			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:151260750G>A	uc001exq.2	+	2	2081	c.1983G>A	c.(1981-1983)CCG>CCA	p.P661P	ZNF687_uc001exp.1_Silent_p.P670P|ZNF687_uc009wmo.2_Silent_p.P661P|ZNF687_uc009wmp.2_Silent_p.P661P	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	661					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCACAGAGCCGCCTGCTGCCC	0.637													18	54					0	0	0	0	A	151260750	A	A	151260750	2	1	38	1	0	0	0	0	0	0	0	1	18159	1074	38	1		1	ZNF687	1	151260750	Silent	SNP	G	TCGA-CN-4726-01A-01D-1434-08	21915	151260750	97989871	8	7925											
RC3H1	149041	broad.mit.edu	37	chr1	173934116	173934116	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatacaattccatttggcaGagcaggaggttttctgctag	10	13	11	7	0	1	2	0	1	1	1	2	3	2	3	1	3	3	4	1	3	3	6			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:173934116G>T	uc001gju.3	-	9	1564	c.1477C>A	c.(1477-1479)CTG>ATG	p.L493M	RC3H1_uc010pms.1_Missense_Mutation_p.L493M|RC3H1_uc001gjv.2_Missense_Mutation_p.L493M|RC3H1_uc010pmt.1_Missense_Mutation_p.L493M	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	493					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CCATTTGGCAGAGCAGGAGGT	0.483													59	150					2.79145e-41	3.65036e-41	1	0	T	173934116	T	T	173934116	3	4	38	1	0	0	0	0	1	0	0	0	13231	933	33	2	1968	2	RC3H1	1	173934116	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	22673366	173934116	75316505	9	7926											
DHX9	1660	broad.mit.edu	37	chr1	182827949	182827949	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcagcgacaaaaccaagtgGgtgtggttccttggtcacct	9	10	11	11	1	2	0	2	0	0	0	3	1	3	0	3	3	2	1	3	3	3	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:182827949G>A	uc001gpr.2	+	10	1145	c.982G>A	c.(982-984)GGT>AGT	p.G328S	DHX9_uc001gps.2_Missense_Mutation_p.G114S	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	328					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						AAACCAAGTGGGTGTGGTTCC	0.438													48	127					0	0	0	0	A	182827949	A	A	182827949	3	1	38	1	0	0	0	0	1	0	0	0	4538	1232	43	4	1016	4	DHX9	1	182827949	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	8893833	182827949	66422672	10	7927											
OBSCN	84033	broad.mit.edu	37	chr1	228480267	228480267	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtgaaaaaccaggaggcCagagaaggggccacagctgt	14	4	15	8	0	0	2	0	1	0	1	0	5	0	3	3	4	2	1	3	4	3	0			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr1:228480267C>T	uc009xez.1	+	40	10691	c.10647C>T	c.(10645-10647)GCC>GCT	p.A3549A	OBSCN_uc001hsn.2_Silent_p.A3549A|OBSCN_uc001hsq.1_Silent_p.A805A	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3549	Ig-like 36.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACCAGGAGGCCAGAGAAGGGG	0.552													4	216					0	0	0	0	T	228480267	T	T	228480267	2	4	38	1	0	0	0	0	0	0	0	1	10866	581	21	4		4	OBSCN	1	228480267	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08	45652318	228480267	20770354	11	7928											
TTC15	51112	broad.mit.edu	37	chr2	3391502	3391502	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcttccaggaggaaaccatCgatcttggcggagatgagtt	10	10	12	9	2	2	2	0	1	2	1	4	6	3	4	2	4	1	1	2	4	1	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr2:3391502C>T	uc002qxm.1	+	2	314	c.108C>T	c.(106-108)ATC>ATT	p.I36I	TTC15_uc002qxn.1_Silent_p.I36I|TTC15_uc010ewm.1_Silent_p.I36I|TTC15_uc002qxl.1_Silent_p.I36I	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	36							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		AGGAAACCATCGATCTTGGCG	0.652													6	20					0	0	0	0	T	3391502	T	T	3391502	2	4	38	1	0	0	0	0	0	0	0	1	16750	874	31	1		1	TTC15	2	3391502	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08		3391502	239807871	12	7929											
AGBL5	60509	broad.mit.edu	37	chr2	27278581	27278581	+	Missense_Mutation	SNP	C	A	A																															gtggagtgaatctgaaccgtCagtacctgaagcctgatgcc																										TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr2:27278581C>A	uc002rie.2	+	7	1157	c.940C>A	c.(940-942)CAG>AAG	p.Q314K	AGBL5_uc002ric.2_Missense_Mutation_p.Q314K|AGBL5_uc002rid.2_Missense_Mutation_p.Q314K|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	314					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGAACCGTCAGTACCTGAA	0.537													24	134					1.55469e-16	1.9398e-16	1	0	A	27278581	A	A	27278581	3	1	38	1	0	0	0	0	1	0	0	0	378	827	29	2	962	2	AGBL5	2	27278581	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	23887079	27278581	215920792	13	7930	16	2									
AGBL5	60509	broad.mit.edu	37	chr2	27278587	27278587	+	Silent	SNP	C	T	T																															tgaatctgaaccgtcagtacCtgaagcctgatgccgtcctg																										TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr2:27278587C>T	uc002rie.2	+	7	1163	c.946C>T	c.(946-948)CTG>TTG	p.L316L	AGBL5_uc002ric.2_Silent_p.L316L|AGBL5_uc002rid.2_Silent_p.L316L|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	316					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGTCAGTACCTGAAGCCTGA	0.542													25	137					0	0	0	0	T	27278587	T	T	27278587	2	4	38	1	0	0	0	0	0	0	0	1	378	680	24	4		4	AGBL5	2	27278587	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08	6	27278587	215920786	14	7931	16	2									
FSHR	2492	broad.mit.edu	37	chr2	49190547	49190547	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagctgcatggcatgcgtGatggtatgccatctttccaa	8	12	10	11	1	1	1	0	1	1	0	3	1	3	1	3	2	4	4	3	2	2	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr2:49190547G>T	uc002rww.2	-	10	1487	c.1413C>A	c.(1411-1413)ATC>ATA	p.I471I	FSHR_uc002rwx.2_Silent_p.I409I|FSHR_uc010fbn.2_Silent_p.I445I	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	471	Cytoplasmic (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TGGCATGCGTGATGGTATGCC	0.542									Gonadal_Dysgenesis_46_XX				16	46					6.31663e-08	7.3424e-08	1	0	T	49190547	T	T	49190547	2	4	38	1	0	0	0	0	0	0	0	1	6107	1280	45	2		2	FSHR	2	49190547	Silent	SNP	G	TCGA-CN-4726-01A-01D-1434-08	21911960	49190547	194008826	15	7932											
APLF	200558	broad.mit.edu	37	chr2	68740274	68740274	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accaaaatcccccgtgattaAtttacctcatgagactactg	13	11	5	12	1	1	2	1	2	0	1	2	3	2	2	4	0	2	0	4	0	5	4			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr2:68740274A>G	uc002sep.2	+	4	577	c.404A>G	c.(403-405)AAT>AGT	p.N135S	APLF_uc010fdf.2_Missense_Mutation_p.N111S	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	135					double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						CCCGTGATTAATTTACCTCAT	0.358													55	126					0	0	0	0	G	68740274	G	G	68740274	3	3	38	1	0	0	0	0	1	0	0	0	776	101	4	5	418	5	APLF	2	68740274	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08	19549727	68740274	174459099	16	7933											
CTNNA2	1496	broad.mit.edu	37	chr2	80620389	80620389	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attgcgattgataagatgacTaagaaaacaagagatctaag	19	9	9	4	1	1	5	0	2	1	3	1	7	1	5	0	0	2	0	0	0	6	5			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr2:80620389T>C	uc010ysh.1	+	7	1115	c.1110T>C	c.(1108-1110)ACT>ACC	p.T370T	CTNNA2_uc010yse.1_Silent_p.T370T|CTNNA2_uc010ysf.1_Silent_p.T370T|CTNNA2_uc010ysg.1_Silent_p.T370T|CTNNA2_uc010ysi.1_Silent_p.T2T	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	370					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						ATAAGATGACTAAGAAAACAA	0.318													56	158					0	0	0	0	C	80620389	C	C	80620389	2	2	38	1	0	0	0	0	0	0	0	1	4030	1509	53	5		5	CTNNA2	2	80620389	Silent	SNP	T	TCGA-CN-4726-01A-01D-1434-08	11880115	80620389	162578984	17	7934											
MAT2A	4144	broad.mit.edu	37	chr2	85769823	85769823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttatgctgctcgttgggtgGcaaaatcccttgttaaagga	9	13	11	8	1	0	0	0	0	0	0	2	1	1	1	1	3	2	5	1	3	5	4			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr2:85769823G>A	uc002spr.2	+	7	1027	c.904G>A	c.(904-906)GCA>ACA	p.A302T	MAT2A_uc010ysr.1_Missense_Mutation_p.A302T|MAT2A_uc010fgk.2_Missense_Mutation_p.A276T|MAT2A_uc010fgl.2_Missense_Mutation_p.A239T	NM_005911	NP_005902	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	302					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TCGTTGGGTGGCAAAATCCCT	0.478													4	112					0	0	0	0	A	85769823	A	A	85769823	3	1	38	1	0	0	0	0	1	0	0	0	9383	1203	42	4	930	4	MAT2A	2	85769823	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	5149434	85769823	157429550	18	7935											
GPR45	11250	broad.mit.edu	37	chr2	105858867	105858867	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgggccccacagtgcgtgctGggctacacggagctccccgc	5	5	14	17	4	0	0	0	0	0	0	1	1	1	1	4	3	4	3	4	3	1	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr2:105858867G>T	uc002tco.1	+	1	668	c.552G>T	c.(550-552)CTG>CTT	p.L184L		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	184	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						AGTGCGTGCTGGGCTACACGG	0.687													9	38					0.00829132	0.0090937	1	0	T	105858867	T	T	105858867	2	4	38	1	0	0	0	0	0	0	0	1	6734	1335	47	4		4	GPR45	2	105858867	Silent	SNP	G	TCGA-CN-4726-01A-01D-1434-08	20089044	105858867	137340506	19	7936											
RGPD4	285190	broad.mit.edu	37	chr2	108496477	108496477	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaattggttcagaagctcAgttccaccacaaaaagtgca	16	8	8	9	0	2	2	2	0	0	2	3	2	3	2	2	1	2	4	2	1	5	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr2:108496477A>C	uc010ywk.1	+	21	5060	c.4978A>C	c.(4978-4980)AGT>CGT	p.S1660R	RGPD4_uc002tdu.2_Missense_Mutation_p.S847R|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1660					intracellular transport		binding			skin(2)	2						TCAGAAGCTCAGTTCCACCAC	0.408													4	237					0	0	0	0	C	108496477	C	C	108496477	3	2	38	1	0	0	0	0	1	0	0	0	13353	188	7	5	5060	5	RGPD4	2	108496477	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08	2637610	108496477	134702896	20	7937											
ZBTB20	26137	broad.mit.edu	37	chr3	114057937	114057937	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagacggagcagacgtaaGtggtcccctccgtgcaggcc	8	5	15	13	3	0	2	0	0	0	2	2	3	2	3	4	4	2	4	4	4	1	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr3:114057937G>C	uc003ebi.2	-	5	2321	c.2141C>G	c.(2140-2142)ACT>AGT	p.T714S	ZBTB20_uc003ebj.2_Missense_Mutation_p.T641S|ZBTB20_uc010hqp.2_Missense_Mutation_p.T641S|ZBTB20_uc003ebk.2_Missense_Mutation_p.T641S|ZBTB20_uc003ebl.2_Missense_Mutation_p.T641S|ZBTB20_uc003ebm.2_Missense_Mutation_p.T641S|ZBTB20_uc003ebn.2_Missense_Mutation_p.T641S	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	714					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GCAGACGTAAGTGGTCCCCTC	0.612													4	138					0	0	0	0	C	114057937	C	C	114057937	3	2	38	1	0	0	0	0	1	0	0	0	17596	1029	36	4	88	4	ZBTB20	3	114057937	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08		114057937	83964493	21	7938											
RAB7A	7879	broad.mit.edu	37	chr3	128526498	128526498	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcgttccagacgattgcacGgaatgcacttaagcaggtgg	10	8	14	9	3	0	1	0	0	0	1	1	3	1	2	1	4	3	4	1	4	2	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr3:128526498G>A	uc003eks.1	+	5	744	c.512G>A	c.(511-513)CGG>CAG	p.R171Q	RAB7A_uc010hsv.1_Missense_Mutation_p.R124Q|RAB7A_uc003ekt.2_Intron	NM_004637	NP_004628	P51149	RAB7A_HUMAN	RAB7, member RAS oncogene family	171					endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding				0				GBM - Glioblastoma multiforme(114;0.231)		ACGATTGCACGGAATGCACTT	0.577													4	234					0	0	0	0	A	128526498	A	A	128526498	3	1	38	1	0	0	0	0	1	0	0	0	13019	1116	39	1	526	1	RAB7A	3	128526498	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	14468561	128526498	69495932	22	7939											
EPHB1	2047	broad.mit.edu	37	chr3	134885846	134885846	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcattacagcacaggccGaggtaagtagaaagcagaga	16	4	12	9	1	0	2	0	0	0	2	0	4	0	2	2	2	4	5	2	2	4	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr3:134885846G>T	uc003eqt.2	+	9	1977	c.1757G>T	c.(1756-1758)CGA>CTA	p.R586L	EPHB1_uc003equ.2_Missense_Mutation_p.R147L	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	586	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						AGCACAGGCCGAGGTAAGTAG	0.547													89	420					1.59228e-47	2.12304e-47	1	0	T	134885846	T	T	134885846	3	4	38	1	0	0	0	0	1	0	0	0	5198	1058	37	3	1791	3	EPHB1	3	134885846	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	6359348	134885846	63136584	23	7940											
FAM194A	131831	broad.mit.edu	37	chr3	150421899	150421900	+	5'Flank	INS	-	C	C																															cagacttctttctgtccctgINSctcttcagcgtctctgaaac																								rs148177227	by1000genomes	TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr3:150421899_150421900insC	uc003eyg.2	-						FAM194A_uc003eyh.2_5'Flank	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831											skin(2)|ovary(1)	3						TTCTGTCCCTGCTCTTCAGCGT	0.545													---	---	---								C	150421900	C	C	150421899	6	5	38	0	1	1	1	0	0	0	0	0	5554	1334	46	0		0	FAM194A	3	150421899	5'Flank	INS	-	TCGA-CN-4726-01A-01D-1434-08	15536053	150421899	47600531	24	7941											
IFT80	57560	broad.mit.edu	37	chr3	160025482	160025482	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acattgaagagacgttgaaaCaactaagtgtgcatagttca	16	10	9	6	1	1	3	1	2	0	1	1	4	1	3	0	0	3	3	0	0	5	5			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr3:160025482C>A	uc011boy.1	-	10	1478	c.1045G>T	c.(1045-1047)GTT>TTT	p.V349F	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Missense_Mutation_p.V212F|IFT80_uc003fdd.1_Missense_Mutation_p.V32F|IFT80_uc003fde.1_Missense_Mutation_p.V212F	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	349						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GACGTTGAAACAACTAAGTGT	0.358													27	61					5.61819e-17	7.07476e-17	1	0	A	160025482	A	A	160025482	3	1	38	1	0	0	0	0	1	0	0	0	7603	478	17	4	1332	4	IFT80	3	160025482	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	9603583	160025482	37996948	25	7942											
GRID2	2895	broad.mit.edu	37	chr4	94138038	94138038	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaacattgtgtgatccaaaGgatccatttgctcagaatat	13	13	7	8	0	2	2	2	1	0	1	4	3	4	3	2	1	2	1	2	1	4	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr4:94138038G>T	uc011cdt.1	+	6	1197	c.939G>T	c.(937-939)AAG>AAT	p.K313N	GRID2_uc010ikx.2_Missense_Mutation_p.K313N|GRID2_uc011cdu.1_Missense_Mutation_p.K218N|GRID2_uc010ikz.1_Translation_Start_Site	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	313	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GTGATCCAAAGGATCCATTTG	0.418													52	179					4.33383e-22	5.50842e-22	1	0	T	94138038	T	T	94138038	3	4	38	1	0	0	0	0	1	0	0	0	6811	991	35	4	961	4	GRID2	4	94138038	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08		94138038	97016238	26	7943											
UNC5C	8633	broad.mit.edu	37	chr4	96256707	96256707	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatataagcttcttcaggcTcaataaggaaatgtggcaga	15	10	9	7	0	3	1	2	0	1	1	3	2	3	2	0	3	1	3	0	3	6	5			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr4:96256707T>C	uc003htp.1	-	2	354	c.200A>G	c.(199-201)GAG>GGG	p.E67G	UNC5C_uc010ilc.1_Missense_Mutation_p.E67G|UNC5C_uc003htq.2_Missense_Mutation_p.E67G	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	67	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TTCTTCAGGCTCAATAAGGAA	0.418													3	140					0	0	0	0	C	96256707	C	C	96256707	3	2	38	1	0	0	0	0	1	0	0	0	17061	1551	54	5	2655	5	UNC5C	4	96256707	Missense_Mutation	SNP	T	TCGA-CN-4726-01A-01D-1434-08	2118669	96256707	94897569	27	7944											
NR3C2	4306	broad.mit.edu	37	chr4	149357399	149357399	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agttgattccagcagggctgCaaaccgaagatgtcatgttc	11	10	11	9	1	1	2	1	1	0	1	3	3	2	2	2	1	3	5	2	1	2	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr4:149357399C>A	uc003ilj.3	-	2	948	c.614G>T	c.(613-615)TGC>TTC	p.C205F	NR3C2_uc003ilk.3_Missense_Mutation_p.C205F|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	205	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	AGCAGGGCTGCAAACCGAAGA	0.537													30	95					7.38237e-10	8.80704e-10	1	0	A	149357399	A	A	149357399	3	1	38	1	0	0	0	0	1	0	0	0	10685	710	25	4	2372	4	NR3C2	4	149357399	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	53100692	149357399	41796877	28	7945											
CMYA5	202333	broad.mit.edu	37	chr5	79032114	79032114	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tactgaactgaaagaatcaaAagccgatgctatgccacagc	16	7	8	10	1	1	3	1	2	0	1	1	4	1	3	2	0	6	1	2	0	7	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr5:79032114A>T	uc003kgc.2	+	2	7598	c.7526A>T	c.(7525-7527)AAA>ATA	p.K2509I		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2509						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAAGAATCAAAAGCCGATGCT	0.368													22	81					0	0	0	0	T	79032114	T	T	79032114	3	4	38	1	0	0	0	0	1	0	0	0	3605	14	1	5	7532	5	CMYA5	5	79032114	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08		79032114	101883146	29	7946											
GPR98	84059	broad.mit.edu	37	chr5	89943453	89943453	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagagagagatttcattcCtgttgaaaaaggagaaacgc	17	8	11	5	1	1	5	1	1	0	4	2	8	2	5	1	1	1	1	1	1	4	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr5:89943453C>T	uc003kju.2	+	17	3257	c.3161C>T	c.(3160-3162)CCT>CTT	p.P1054L	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1054	Calx-beta 8.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GATTTCATTCCTGTTGAAAAA	0.423													41	137					0	0	0	0	T	89943453	T	T	89943453	3	4	38	1	0	0	0	0	1	0	0	0	6760	681	24	4	3227	4	GPR98	5	89943453	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	10911339	89943453	90971807	30	7947											
GPR98	84059	broad.mit.edu	37	chr5	90106533	90106533	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgacacaactctcattccTgtagaaactgaatccaccac	13	10	5	13	0	1	3	1	2	1	1	4	3	3	3	3	0	2	2	3	0	4	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr5:90106533T>C	uc003kju.2	+	74	15552	c.15456T>C	c.(15454-15456)CCT>CCC	p.P5152P	GPR98_uc003kjt.2_Silent_p.P2858P|GPR98_uc003kjw.2_Silent_p.P813P	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5152	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTCTCATTCCTGTAGAAACTG	0.458													85	237					0	0	0	0	C	90106533	C	C	90106533	2	2	38	1	0	0	0	0	0	0	0	1	6760	1567	55	5		5	GPR98	5	90106533	Silent	SNP	T	TCGA-CN-4726-01A-01D-1434-08	163080	90106533	90808727	31	7948											
SLC23A1	9963	broad.mit.edu	37	chr5	138714989	138714989	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caatgatgcctgccagagtgGcgctgaacattcccaggaca	11	7	11	12	1	0	3	0	2	0	1	1	4	1	4	3	2	3	1	3	2	2	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr5:138714989G>A	uc003leh.2	-	9	1077	c.980C>T	c.(979-981)GCC>GTC	p.A327V	SLC23A1_uc003leg.2_Missense_Mutation_p.A331V	NM_005847	NP_005838	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (nucleobase	327	Helical; (Potential).				brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	TGCCAGAGTGGCGCTGAACAT	0.607													34	78					0	0	0	0	A	138714989	A	A	138714989	3	1	38	1	0	0	0	0	1	0	0	0	14526	1203	42	4	840	4	SLC23A1	5	138714989	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	48608456	138714989	42200271	32	7949											
PCDHA2	56146	broad.mit.edu	37	chr5	140176610	140176610	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgggcgtgggtgggcgccgcGggctcagaggctacgctggt	3	6	21	11	6	1	1	1	0	0	1	1	1	1	1	1	6	1	3	1	6	1	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr5:140176610G>T	uc003lhd.2	+	1	2167	c.2061G>T	c.(2059-2061)GCG>GCT	p.A687A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.A687A|PCDHA2_uc011czy.1_Silent_p.A687A	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	687	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGCGCCGCGGGCTCAGAGG	0.647													39	152					5.57489e-27	7.22081e-27	1	0	T	140176610	T	T	140176610	2	4	38	1	0	0	0	0	0	0	0	1	11578	1103	39	3		3	PCDHA2	5	140176610	Silent	SNP	G	TCGA-CN-4726-01A-01D-1434-08	1461621	140176610	40738650	33	7950											
PCDHA13	56136	broad.mit.edu	37	chr5	140261993	140261993	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acacggcaccttcgtgggccGcatcgctcaggacctggggc	6	6	14	15	4	1	0	1	0	0	0	3	1	1	1	3	5	0	3	3	5	0	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr5:140261993G>A	uc003lif.2	+	1	140	c.140G>A	c.(139-141)CGC>CAC	p.R47H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.R47H|PCDHA13_uc003lid.2_Missense_Mutation_p.R47H	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	47	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGTGGGCCGCATCGCTCAG	0.642													78	221					0	0	0	0	A	140261993	A	A	140261993	3	1	38	1	0	0	0	0	1	0	0	0	11577	1087	38	1	142	1	PCDHA13	5	140261993	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	85383	140261993	40653267	34	7951											
ABLIM3	22885	broad.mit.edu	37	chr5	148620311	148620311	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccactccaacctcttaccAggctcccaagcactttcaca	10	9	3	19	0	2	0	1	0	1	0	5	0	5	0	5	1	3	2	5	1	3	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr5:148620311A>G	uc003lpy.2	+	14	1528	c.1277A>G	c.(1276-1278)CAG>CGG	p.Q426R	ABLIM3_uc003lpz.1_Missense_Mutation_p.Q426R|ABLIM3_uc003lqa.1_Intron|ABLIM3_uc003lqb.2_Intron|ABLIM3_uc003lqc.1_Intron|ABLIM3_uc003lqd.1_Intron|ABLIM3_uc003lqf.2_Intron|ABLIM3_uc003lqe.1_Intron	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	426					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTCTTACCAGGCTCCCAAG	0.592													3	201					0	0	0	0	G	148620311	G	G	148620311	3	3	38	1	0	0	0	0	1	0	0	0	96	188	7	5	1327	5	ABLIM3	5	148620311	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08	8358318	148620311	32294949	35	7952											
SLU7	10569	broad.mit.edu	37	chr5	159831502	159831502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactatctgaactgctctttCgatgcttcttctttttcttt	5	21	4	11	1	5	1	0	1	5	0	6	2	5	1	0	0	3	2	0	0	2	7			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr5:159831502C>T	uc003lyg.2	-	15	1681	c.1526G>A	c.(1525-1527)CGA>CAA	p.R509Q		NM_006425	NP_006416	O95391	SLU7_HUMAN	step II splicing factor SLU7	509					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTGCTCTTTCGATGcttctt	0.269													16	104					0	0	0	0	T	159831502	T	T	159831502	3	4	38	1	0	0	0	0	1	0	0	0	14819	884	31	1	242	1	SLU7	5	159831502	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	11211191	159831502	21083758	36	7953											
HIST1H2BH	8345	broad.mit.edu	37	chr6	26251971	26251971	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaggatggcaagaagcgtaaAcgcagccgcaaggagagcta	16	3	14	8	3	0	2	0	0	0	2	0	4	0	3	1	3	4	5	1	3	7	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr6:26251971A>G	uc003nhh.2	+	1	93	c.93A>G	c.(91-93)AAA>AAG	p.K31K	HIST1H3F_uc003nhg.1_5'Flank	NM_003524	NP_003515	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	31					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)	3						AGAAGCGTAAACGCAGCCGCA	0.557													62	206					0	0	0	0	G	26251971	G	G	26251971	2	3	38	1	0	0	0	0	0	0	0	1	7186	40	2	5		5	HIST1H2BH	6	26251971	Silent	SNP	A	TCGA-CN-4726-01A-01D-1434-08		26251971	144863096	37	7954											
TRIM39	56658	broad.mit.edu	37	chr6	30309645	30309645	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctggctactgagggtttcaCctcaggtcgacactactggg	7	10	12	12	1	2	1	2	1	0	0	3	2	2	1	2	4	2	2	2	4	2	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr6:30309645C>T	uc010jrz.2	+	9	1478	c.1166C>T	c.(1165-1167)ACC>ATC	p.T389I	TRIM39_uc003npz.2_Missense_Mutation_p.T359I|TRIM39_uc003nqb.2_Missense_Mutation_p.T359I|TRIM39_uc003nqc.2_Missense_Mutation_p.T359I|TRIM39_uc010jsa.1_Missense_Mutation_p.T359I	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	389	B30.2/SPRY.				apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						GAGGGTTTCACCTCAGGTCGA	0.592													22	94					0	0	0	0	T	30309645	T	T	30309645	3	4	38	1	0	0	0	0	1	0	0	0	16580	507	18	4	1192	4	TRIM39	6	30309645	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	4057674	30309645	140805422	38	7955											
HLA-C	3107	broad.mit.edu	37	chr6	31238903	31238903	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtatctgcggagccactccAcgcacgtgccctccaggtag	7	7	12	15	3	1	0	0	0	1	0	3	1	3	1	4	3	3	3	4	3	2	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr6:31238903A>T	uc003nsy.2	-	3	573	c.566T>A	c.(565-567)GTG>GAG	p.V189E	HLA-C_uc011dnj.1_Missense_Mutation_p.V161E|HLA-C_uc003nsx.2_Missense_Mutation_p.V68E|HLA-C_uc003nsz.2_Missense_Mutation_p.V189E|HLA-C_uc010jsl.2_Missense_Mutation_p.V189E|HLA-C_uc003nta.2_Missense_Mutation_p.V189E|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_Missense_Mutation_p.V68E|HLA-B_uc003ntf.2_Missense_Mutation_p.V189E	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	189	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						GAGCCACTCCACGCACGTGCC	0.677													4	65					0	0	0	0	T	31238903	T	T	31238903	3	4	38	1	0	0	0	0	1	0	0	0	7236	159	6	5	558	5	HLA-C	6	31238903	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08	929258	31238903	139876164	39	7956											
MRPS10	55173	broad.mit.edu	37	chr6	42185571	42185571	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccggcacacagcaccgaacGctgtccgcgccgccatcttg	7	5	11	18	6	1	0	0	0	1	0	2	1	2	0	5	1	2	3	5	1	1	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr6:42185571G>A	uc003osa.3	-	1	63	c.17C>T	c.(16-18)GCG>GTG	p.A6V	MRPS10_uc011dup.1_5'UTR	NM_018141	NP_060611	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	6					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			AGCACCGAACGCTGTCCGCGC	0.597													12	53					0	0	0	0	A	42185571	A	A	42185571	3	1	38	1	0	0	0	0	1	0	0	0	9874	1087	38	1	616	1	MRPS10	6	42185571	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	10946668	42185571	128929496	40	7957											
TMEM63B	55362	broad.mit.edu	37	chr6	44117677	44117677	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccatcgtctactactcaGccttctttgaagcccactgg	8	11	6	16	1	3	1	1	1	2	0	4	1	3	1	4	1	4	0	4	1	3	4			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr6:44117677G>T	uc003owr.2	+	16	1559	c.1495G>T	c.(1495-1497)GCC>TCC	p.A499S	TMEM63B_uc003ows.2_Missense_Mutation_p.A402S|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	499	Helical; (Potential).					integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CTACTACTCAGCCTTCTTTGA	0.602													11	23					1.41608e-15	1.75079e-15	1	0	T	44117677	T	T	44117677	3	4	38	1	0	0	0	0	1	0	0	0	16257	971	34	4	1553	4	TMEM63B	6	44117677	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	1932106	44117677	126997390	41	7958											
KCNQ5	56479	broad.mit.edu	37	chr6	73900382	73900382	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtcattgaacaatattctgCtggtcatctggacatgttgt	9	16	9	7	0	4	1	2	1	2	0	4	2	4	2	0	2	2	2	0	2	3	4			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr6:73900382C>A	uc003pgk.2	+	12	2011	c.1664C>A	c.(1663-1665)GCT>GAT	p.A555D	KCNQ5_uc011dyh.1_Missense_Mutation_p.A574D|KCNQ5_uc011dyi.1_Missense_Mutation_p.A565D|KCNQ5_uc010kat.2_Missense_Mutation_p.A546D|KCNQ5_uc011dyj.1_Missense_Mutation_p.A445D|KCNQ5_uc011dyk.1_Missense_Mutation_p.A305D	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	555					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CAATATTCTGCTGGTCATCTG	0.353													29	81					1.16021e-09	1.37207e-09	1	0	A	73900382	A	A	73900382	3	1	38	1	0	0	0	0	1	0	0	0	8125	797	28	4	1771	4	KCNQ5	6	73900382	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	29782705	73900382	97214685	42	7959											
FAM71F1	84691	broad.mit.edu	37	chr7	128359088	128359088	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaccctaggattcttgtcaCgcactgcctggtacccaaga	10	9	9	13	1	2	2	1	0	1	2	2	3	2	3	3	2	2	2	3	2	3	4			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr7:128359088C>T	uc003vno.1	+	3	691	c.638C>T	c.(637-639)ACG>ATG	p.T213M	FAM71F1_uc010llo.1_Missense_Mutation_p.T114M|FAM71F1_uc011koq.1_Missense_Mutation_p.T105M|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.T114M|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.T213M	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	213										skin(1)	1						ATTCTTGTCACGCACTGCCTG	0.537													5	214					0	0	0	0	T	128359088	T	T	128359088	3	4	38	1	0	0	0	0	1	0	0	0	5644	536	19	1	648	1	FAM71F1	7	128359088	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08		128359088	30779575	43	7960											
PLXNA4	91584	broad.mit.edu	37	chr7	132192727	132192727	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaaccatagacatagtaGatatcaaagtcagggatgat	18	9	8	6	0	2	3	2	1	0	2	2	4	2	4	1	1	1	1	1	1	7	5			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr7:132192727G>T	uc003vra.3	-	2	955	c.726C>A	c.(724-726)ATC>ATA	p.I242I	PLXNA4_uc003vrc.2_Silent_p.I242I|PLXNA4_uc003vrb.2_Silent_p.I242I	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	242	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AGACATAGTAGATATCAAAGT	0.498													20	89					1.01871e-10	1.22606e-10	1	0	T	132192727	T	T	132192727	2	4	38	1	0	0	0	0	0	0	0	1	12177	932	33	2		2	PLXNA4	7	132192727	Silent	SNP	G	TCGA-CN-4726-01A-01D-1434-08	3833639	132192727	26945936	44	7961											
TBXAS1	6916	broad.mit.edu	37	chr7	139636105	139636105	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcctgaaaagctgaacgAggtaagacatgagaaatgca	17	6	11	7	1	0	4	0	3	0	2	1	6	1	4	1	1	3	3	1	1	5	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr7:139636105A>T	uc011kqv.1	+	5	616	c.452A>T	c.(451-453)GAG>GTG	p.E151V	TBXAS1_uc003vvh.2_Missense_Mutation_p.E151V|TBXAS1_uc010lne.2_Missense_Mutation_p.E83V|TBXAS1_uc011kqu.1_Missense_Mutation_p.E102V|TBXAS1_uc003vvi.2_Missense_Mutation_p.E151V|TBXAS1_uc003vvj.2_Missense_Mutation_p.E151V|TBXAS1_uc011kqw.1_Missense_Mutation_p.E131V	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	150	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					AAGCTGAACGAGGTAAGACAT	0.473													92	288					0	0	0	0	T	139636105	T	T	139636105	3	4	38	1	0	0	0	0	1	0	0	0	15730	318	11	5	470	5	TBXAS1	7	139636105	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08	7443378	139636105	19502558	45	7962											
EPHA1	2041	broad.mit.edu	37	chr7	143088775	143088775	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccgagtggaagtgcaggatGtagcgtttcatgcgtatgga	9	10	16	6	3	1	0	1	0	0	0	1	4	1	3	1	3	3	4	1	3	3	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr7:143088775G>T	uc003wcz.2	-	17	2877	c.2790C>A	c.(2788-2790)TAC>TAA	p.Y930*		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	930	SAM.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				AGTGCAGGATGTAGCGTTTCA	0.607													13	41					1.02788e-11	1.25939e-11	1	0	T	143088775	T	T	143088775	4	4	38	1	0	0	0	0	0	1	0	0	5189	1372	48	4	148	4	EPHA1	7	143088775	Nonsense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	3452670	143088775	16049888	46	7963											
WDR67	93594	broad.mit.edu	37	chr8	124156985	124156985	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agctgaaggaaaagagttccGtttgagatcagcaaagaaag	17	7	12	5	1	1	4	1	2	0	3	2	6	2	5	1	1	2	4	1	1	5	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr8:124156985G>A	uc003ypp.1	+	20	2954	c.2864G>A	c.(2863-2865)CGT>CAT	p.R955H	WDR67_uc011lig.1_Missense_Mutation_p.R859H|WDR67_uc011lih.1_Missense_Mutation_p.R845H|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Missense_Mutation_p.R589H|WDR67_uc003ypt.1_Missense_Mutation_p.R347H|WDR67_uc003ypu.1_Missense_Mutation_p.R347H	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	955						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			AAAGAGTTCCGTTTGAGATCA	0.358													24	101					0	0	0	0	A	124156985	A	A	124156985	3	1	38	1	0	0	0	0	1	0	0	0	17386	1145	40	1	2942	1	WDR67	8	124156985	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08		124156985	22207037	47	7964											
ADCY8	114	broad.mit.edu	37	chr8	131949376	131949376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagtgggcatggtcctggCggggctcaggaagtccagac	8	6	17	10	1	1	1	1	0	0	1	3	2	3	2	2	6	1	3	2	6	1	0			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr8:131949376C>T	uc003ytd.3	-	5	1680	c.1424G>A	c.(1423-1425)CGC>CAC	p.R475H	ADCY8_uc010mds.2_Missense_Mutation_p.R475H	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	475	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			ATGGTCCTGGCGGGGCTCAGG	0.507										HNSCC(32;0.087)			25	131					0	0	0	0	T	131949376	T	T	131949376	3	4	38	1	0	0	0	0	1	0	0	0	300	768	27	1	2387	1	ADCY8	8	131949376	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	7792391	131949376	14414646	48	7965											
PTK2	5747	broad.mit.edu	37	chr8	141678371	141678371	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatgactctattttaccttCaccatagggacatactcctc	12	13	4	12	0	2	1	1	1	1	0	4	2	3	2	3	1	2	0	3	1	5	6			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr8:141678371C>T	uc003yvu.2	-	30	3092	c.2862G>A	c.(2860-2862)GTG>GTA	p.V954V	PTK2_uc011ljp.1_Silent_p.V262V|PTK2_uc003yvo.2_Silent_p.V582V|PTK2_uc011ljq.1_Silent_p.V652V|PTK2_uc003yvp.2_Silent_p.V622V|PTK2_uc003yvq.2_Silent_p.V459V|PTK2_uc003yvr.2_Silent_p.V897V|PTK2_uc003yvs.2_Silent_p.V908V|PTK2_uc003yvt.2_Silent_p.V976V|PTK2_uc003yvv.2_Silent_p.V857V|PTK2_uc011ljr.1_Silent_p.V967V	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	954	Interaction with TGFB1I1.|Interaction with RGNEF (By similarity).				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			ATTTTACCTTCACCATAGGGA	0.488											OREG0019022	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	83					0	0	0	0	T	141678371	T	T	141678371	2	4	38	1	0	0	0	0	0	0	0	1	12825	813	29	2		2	PTK2	8	141678371	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08	9728995	141678371	4685651	49	7966											
PTK2	5747	broad.mit.edu	37	chr8	141856357	141856357	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agattgtaagtacaatacttActctaatacttcatagttag	15	15	5	6	0	2	1	1	0	1	1	2	1	2	1	0	0	4	3	0	0	9	10			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr8:141856357A>G	uc003yvu.2	-	7	823	c.593_splice	c.e7+1	p.E198_splice	PTK2_uc003yvq.2_Intron|PTK2_uc003yvr.2_Splice_Site_p.E97_splice|PTK2_uc003yvs.2_Splice_Site_p.E198_splice|PTK2_uc003yvt.2_Splice_Site_p.E220_splice|PTK2_uc003yvv.2_Splice_Site_p.E85_splice|PTK2_uc011ljr.1_Splice_Site_p.E198_splice	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a						axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TACAATACTTACTCTAATACT	0.303													27	124					0	0	0	0	G	141856357	G	G	141856357	5	3	38	1	0	0	0	0	0	0	1	0	12825	405	14	5	2667	5	PTK2	8	141856357	Splice_Site	SNP	A	TCGA-CN-4726-01A-01D-1434-08	177986	141856357	4507665	50	7967											
KIF27	55582	broad.mit.edu	37	chr9	86482718	86482718	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagctcctctaattcttggcGttggttcagaactttctcta	7	16	7	11	1	4	1	1	0	3	1	6	1	5	1	1	2	2	3	1	2	3	7	rs3199677	by1000genomes	TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr9:86482718G>A	uc004ana.2	-	13	2959	c.2815C>T	c.(2815-2817)CGC>TGC	p.R939C	KIF27_uc010mpw.2_Missense_Mutation_p.R873C|KIF27_uc010mpx.2_Intron	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	939	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						AATTCTTGGCGTTGGTTCAGA	0.373													18	158					0	0	0	0	A	86482718	A	A	86482718	3	1	38	1	0	0	0	0	1	0	0	0	8335	1145	40	1	1414	1	KIF27	9	86482718	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08		86482718	54730713	51	7968											
SCAI	286205	broad.mit.edu	37	chr9	127734036	127734036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttttcccataggcctctgCgcatgcttgacaatccagag	9	11	8	13	1	1	2	0	1	1	1	3	2	3	2	3	1	2	2	3	1	2	4			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr9:127734036C>T	uc004bpe.2	-	16	1568	c.1487G>A	c.(1486-1488)CGC>CAC	p.R496H	SCAI_uc004bpd.2_Missense_Mutation_p.R519H|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	496					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						TAGGCCTCTGCGCATGCTTGA	0.423													53	163					0	0	0	0	T	127734036	T	T	127734036	3	4	38	1	0	0	0	0	1	0	0	0	13934	768	27	1	345	1	SCAI	9	127734036	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	41251318	127734036	13479395	52	7969											
AGAP5	729092	broad.mit.edu	37	chr10	75434549	75434549	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatggagcgccgtgcagccGtctccctccccacaggtctc	6	7	11	17	3	2	1	0	0	2	1	5	2	3	2	5	2	3	1	5	2	0	0			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr10:75434549G>C	uc009xri.2	-	8	1910	c.1869C>G	c.(1867-1869)GAC>GAG	p.D623E	AGAP5_uc001juu.3_Missense_Mutation_p.D584E	NM_001144000	NP_001137472	A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	623	ANK 1.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						CCGTGCAGCCGTCTCCCTCCC	0.662													38	223					0	0	0	0	C	75434549	C	C	75434549	3	2	38	1	0	0	0	0	1	0	0	0	371	1136	40	3	195	3	AGAP5	10	75434549	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08		75434549	60100198	53	7970											
GBF1	8729	broad.mit.edu	37	chr10	104118286	104118286	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcatgcccttcattgatgtgCccactcccatctcctctgca	6	12	6	17	0	3	1	1	1	2	0	5	1	4	1	4	0	3	2	4	0	0	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr10:104118286C>T	uc001kux.1	+	10	1051	c.811C>T	c.(811-813)CCC>TCC	p.P271S	GBF1_uc001kuw.2_Missense_Mutation_p.P271S|GBF1_uc001kuy.1_Missense_Mutation_p.P271S|GBF1_uc001kuz.1_Missense_Mutation_p.P271S	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	271					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CATTGATGTGCCCACTCCCAT	0.517													4	145					0	0	0	0	T	104118286	T	T	104118286	3	4	38	1	0	0	0	0	1	0	0	0	6306	739	26	4	845	4	GBF1	10	104118286	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	28683737	104118286	31416461	54	7971											
TMEM80	283232	broad.mit.edu	37	chr11	703061	703061	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcaggccctagtgttgtggGcggactgggccctcagcgcc	4	7	17	13	2	1	0	1	0	0	0	1	1	1	1	3	5	1	2	3	5	1	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr11:703061G>A	uc001lqr.2	+	5	555	c.418G>A	c.(418-420)GCG>ACG	p.A140T	TMEM80_uc001lqs.2_Missense_Mutation_p.A132T|TMEM80_uc010qwi.1_Missense_Mutation_p.A140T	NM_001042463	NP_001035928	Q96HE8	TMM80_HUMAN	transmembrane protein 80 isoform 2	140	Helical; (Potential).					integral to membrane					0		all_cancers(49;5.11e-06)|all_epithelial(84;0.00143)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.44e-27)|Epithelial(43;2.29e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.19e-20)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGTGTTGTGGGCGGACTGGGC	0.697													30	61					0	0	0	0	A	703061	A	A	703061	3	1	38	1	0	0	0	0	1	0	0	0	16270	1203	42	4	436	4	TMEM80	11	703061	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08		703061	134303455	55	7972											
TRAF6	7189	broad.mit.edu	37	chr11	36511809	36511809	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acagtttgtacccgggtttgCcagtgtagaatccagggcta	9	11	12	9	1	0	1	0	0	0	1	1	1	1	1	3	2	2	5	3	2	4	5			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr11:36511809C>T	uc001mwr.1	-	8	1488	c.1148G>A	c.(1147-1149)GGC>GAC	p.G383D	uc001mwq.1_5'Flank|TRAF6_uc001mws.1_Missense_Mutation_p.G383D	NM_145803	NP_665802	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6	383	MATH.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				CCCGGGTTTGCCAGTGTAGAA	0.433													4	277					0	0	0	0	T	36511809	T	T	36511809	3	4	38	1	0	0	0	0	1	0	0	0	16512	739	26	4	424	4	TRAF6	11	36511809	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	35808748	36511809	98494707	56	7973											
OR5M10	390167	broad.mit.edu	37	chr11	56345153	56345153	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgggtcgtctgtcagtccTaagagaatgaattctgtcac	10	12	10	9	1	4	2	2	1	2	1	6	3	5	2	1	1	0	0	1	1	3	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr11:56345153T>C	uc001niz.1	-	1	45	c.45A>G	c.(43-45)TTA>TTG	p.L15L		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGTCAGTCCTAAGAGAATGA	0.458													7	149					0	0	0	0	C	56345153	C	C	56345153	2	2	38	1	0	0	0	0	0	0	0	1	11227	1519	53	5		5	OR5M10	11	56345153	Silent	SNP	T	TCGA-CN-4726-01A-01D-1434-08	19833344	56345153	78661363	57	7974											
OR5M1	390168	broad.mit.edu	37	chr11	56380883	56380883	+	Silent	SNP	A	C	C																															agtgtgattaggtagatcgcAaggaataccccaaacaggat																										TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr11:56380883A>C	uc001nja.1	-	1	96	c.96T>G	c.(94-96)CTT>CTG	p.L32L		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GGTAGATCGCAAGGAATACCC	0.493													10	124					0	0	0	0	C	56380883	C	C	56380883	2	2	38	1	0	0	0	0	0	0	0	1	11226	117	5	5		5	OR5M1	11	56380883	Silent	SNP	A	TCGA-CN-4726-01A-01D-1434-08	35730	56380883	78625633	58	7975	17	2									
OR5M1	390168	broad.mit.edu	37	chr11	56380889	56380889	+	Silent	SNP	T	C	C																															attaggtagatcgcaaggaaTaccccaaacaggatcttctc																										TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr11:56380889T>C	uc001nja.1	-	1	90	c.90A>G	c.(88-90)GTA>GTG	p.V30V		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TCGCAAGGAATACCCCAAACA	0.478													13	127					0	0	0	0	C	56380889	C	C	56380889	2	2	38	1	0	0	0	0	0	0	0	1	11226	1393	49	5		5	OR5M1	11	56380889	Silent	SNP	T	TCGA-CN-4726-01A-01D-1434-08	6	56380889	78625627	59	7976	17	2									
TMEM179B	374395	broad.mit.edu	37	chr11	62557444	62557444	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctgaagccaccccataccgGcctctggagaggggtgaccc	8	6	12	15	1	2	3	0	2	2	1	2	4	2	3	6	4	2	0	6	4	2	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr11:62557444G>A	uc001nvd.3	+	5	615	c.585G>A	c.(583-585)CGG>CGA	p.R195R		NM_199337	NP_955369	Q7Z7N9	T179B_HUMAN	transmembrane protein 179B	195						integral to membrane					0						CCCCATACCGGCCTCTGGAGA	0.557													75	232					0	0	0	0	A	62557444	A	A	62557444	2	1	38	1	0	0	0	0	0	0	0	1	16163	1190	42	4		4	TMEM179B	11	62557444	Silent	SNP	G	TCGA-CN-4726-01A-01D-1434-08	6176555	62557444	72449072	60	7977											
CCDC77	84318	broad.mit.edu	37	chr12	539877	539877	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgtaggtgaatgtgagcaGagtgaatcttcagctttcaa	11	12	12	6	0	3	4	2	3	1	1	3	4	3	4	0	1	2	4	0	1	4	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr12:539877G>C	uc001qig.2	+	7	738	c.558G>C	c.(556-558)CAG>CAC	p.Q186H	CCDC77_uc009zdk.2_Missense_Mutation_p.Q154H|CCDC77_uc010sdp.1_Missense_Mutation_p.Q154H|CCDC77_uc010sdq.1_Missense_Mutation_p.Q154H	NM_032358	NP_115734	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77 isoform a	186						centrosome				ovary(1)	1	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			AATGTGAGCAGAGTGAATCTT	0.343													67	252					0	0	0	0	C	539877	C	C	539877	3	2	38	1	0	0	0	0	1	0	0	0	2864	933	33	2	576	2	CCDC77	12	539877	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08		539877	133312018	61	7978											
GRIN2B	2904	broad.mit.edu	37	chr12	13717097	13717097	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcttggaggaggggaggccGatgtccaggggcttcttgct	5	10	18	8	1	1	0	0	0	1	0	2	4	2	3	2	7	2	3	2	7	0	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr12:13717097G>A	uc001rbt.2	-	13	3254	c.3075C>T	c.(3073-3075)ATC>ATT	p.I1025I		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1025	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGGGAGGCCGATGTCCAGGG	0.587													19	56					0	0	0	0	A	13717097	A	A	13717097	2	1	38	1	0	0	0	0	0	0	0	1	6819	1048	37	1		1	GRIN2B	12	13717097	Silent	SNP	G	TCGA-CN-4726-01A-01D-1434-08	13177220	13717097	120134798	62	7979											
CAPRIN2	65981	broad.mit.edu	37	chr12	30863009	30863009	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attggcataggctgataccaAgacctcttcattcttcatga	11	13	7	10	0	4	3	2	2	2	1	4	3	4	3	2	2	1	2	2	2	3	6			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr12:30863009A>C	uc001rji.1	-	18	3962	c.3211T>G	c.(3211-3213)TTG>GTG	p.L1071V	CAPRIN2_uc001rjf.1_3'UTR|CAPRIN2_uc001rjg.1_Missense_Mutation_p.L738V|CAPRIN2_uc001rjh.1_Missense_Mutation_p.L1021V|CAPRIN2_uc001rjj.1_Missense_Mutation_p.L737V|CAPRIN2_uc001rjk.3_3'UTR|CAPRIN2_uc001rjl.3_3'UTR	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	1071	C1q.				negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GCTGATACCAAGACCTCTTCA	0.443													35	124					0	0	0	0	C	30863009	C	C	30863009	3	2	38	1	0	0	0	0	1	0	0	0	2648	69	3	5	176	5	CAPRIN2	12	30863009	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08	17145912	30863009	102988886	63	7980											
DDN	23109	broad.mit.edu	37	chr12	49391856	49391856	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatccagcctcttctttgtgCgccctccgtctgtcctggct	2	14	9	16	2	3	0	0	0	3	0	6	1	6	0	5	1	2	1	5	1	0	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr12:49391856C>T	uc001rsv.1	-	2	821	c.803G>A	c.(802-804)CGC>CAC	p.R268H	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	268						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						CTTCTTTGTGCGCCCTCCGTC	0.652													5	158					0	0	0	0	T	49391856	T	T	49391856	3	4	38	1	0	0	0	0	1	0	0	0	4350	768	27	1	1336	1	DDN	12	49391856	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	18528847	49391856	84460039	64	7981											
DDN	23109	broad.mit.edu	37	chr12	49391990	49391990	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggagccacgtagggtggcggCcggtcccagcggcgtcgtgg	4	5	20	12	6	0	0	0	0	0	0	2	1	1	1	3	7	2	1	3	7	1	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr12:49391990C>T	uc001rsv.1	-	2	687	c.669G>A	c.(667-669)CGG>CGA	p.R223R	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	223	Interaction with MAGI2.					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						AGGGTGGCGGCCGGTCCCAGC	0.701													3	61					0	0	0	0	T	49391990	T	T	49391990	2	4	38	1	0	0	0	0	0	0	0	1	4350	726	26	4		4	DDN	12	49391990	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08	134	49391990	84459905	65	7982											
AAAS	8086	broad.mit.edu	37	chr12	53715239	53715239	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggaggagggaacaaccccAgagagcacatcttgccggtt	11	6	14	10	1	1	1	0	0	1	1	1	5	1	4	3	4	4	2	3	4	2	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr12:53715239A>C	uc001scr.3	-	1	174	c.11T>G	c.(10-12)CTG>CGG	p.L4R	AAAS_uc001scs.3_Missense_Mutation_p.L4R	NM_015665	NP_056480	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency,	4					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				ovary(1)	1						GAACAACCCCAGAGAGCACAT	0.622											OREG0021865	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	103	239					0	0	0	0	C	53715239	C	C	53715239	3	2	38	1	0	0	0	0	1	0	0	0	8	188	7	5	1693	5	AAAS	12	53715239	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08	4323249	53715239	80136656	66	7983											
ZBTB39	9880	broad.mit.edu	37	chr12	57398238	57398238	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacctcggagttctccaaggGgatgggcaggttctgccgaa	8	8	14	11	2	2	0	0	0	2	0	4	3	2	2	3	5	1	3	3	5	2	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr12:57398238G>A	uc001sml.1	-	2	550	c.464C>T	c.(463-465)CCC>CTC	p.P155L	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						TTCTCCAAGGGGATGGGCAGG	0.552													79	151					0	0	0	0	A	57398238	A	A	57398238	3	1	38	1	0	0	0	0	1	0	0	0	17607	1232	43	4	1678	4	ZBTB39	12	57398238	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	3682999	57398238	76453657	67	7984											
RNF10	9921	broad.mit.edu	37	chr12	120995094	120995094	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttgtttcagcgcatttgtAgccatgaagtgccatcttgc	7	16	9	9	1	2	1	1	1	1	0	2	1	2	1	2	0	4	3	2	0	2	6			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr12:120995094A>G	uc001typ.3	+	5	1138	c.655A>G	c.(655-657)AGC>GGC	p.S219G	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.S125G	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	219					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCGCATTTGTAGCCATGAAGT	0.483													3	212					0	0	0	0	G	120995094	G	G	120995094	3	3	38	1	0	0	0	0	1	0	0	0	13487	420	15	5	673	5	RNF10	12	120995094	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08	63596856	120995094	12856801	68	7985											
TPTE2	93492	broad.mit.edu	37	chr13	19997299	19997299	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaattcatttcttggtagaCaaagcctaagaatagaaaaa	18	10	6	7	0	2	3	1	0	1	3	2	3	2	3	2	1	1	1	2	1	8	6			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr13:19997299C>A	uc001umd.2	-	21	1683	c.1472G>T	c.(1471-1473)TGT>TTT	p.C491F	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.C380F|TPTE2_uc001ume.2_Missense_Mutation_p.C414F|TPTE2_uc009zzm.2_Missense_Mutation_p.C162F|TPTE2_uc010tcm.1_RNA|TPTE2_uc010tcl.1_Missense_Mutation_p.C162F	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	491	C2 tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TCTTGGTAGACAAAGCCTAAG	0.353													10	89					2.17888e-05	2.49015e-05	1	0	A	19997299	A	A	19997299	3	1	38	1	0	0	0	0	1	0	0	0	16498	478	17	4	100	4	TPTE2	13	19997299	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08		19997299	95172579	69	7986											
IFT88	8100	broad.mit.edu	37	chr13	21219018	21219018	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgtaatattgaagtcattGagtggcttggagcctattac	10	15	10	6	0	1	2	1	2	0	0	1	3	1	3	1	2	2	2	1	2	5	8			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr13:21219018G>A	uc001unh.2	+	22	2293	c.1897G>A	c.(1897-1899)GAG>AAG	p.E633K	IFT88_uc001uni.2_Missense_Mutation_p.E624K|IFT88_uc001unj.2_Missense_Mutation_p.E623K|IFT88_uc010tcq.1_Missense_Mutation_p.E604K	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	633	TPR 11.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TGAAGTCATTGAGTGGCTTGG	0.308													36	149					0	0	0	0	A	21219018	A	A	21219018	3	1	38	1	0	0	0	0	1	0	0	0	7605	1291	45	2	1975	2	IFT88	13	21219018	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	1221719	21219018	93950860	70	7987											
C14orf93	60686	broad.mit.edu	37	chr14	23459034	23459034	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaagaaacttcactactgaaAtattccaagaggacttgatg	16	10	8	7	0	1	4	1	2	0	2	2	6	2	5	1	1	2	0	1	1	6	5			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr14:23459034A>G	uc001wib.1	-	5	1311	c.1001T>C	c.(1000-1002)ATT>ACT	p.I334T	C14orf93_uc001wic.1_Missense_Mutation_p.I154T|C14orf93_uc001wid.1_Missense_Mutation_p.I334T|C14orf93_uc001wig.2_Missense_Mutation_p.I334T|C14orf93_uc001wih.2_Missense_Mutation_p.I334T|C14orf93_uc001wie.2_Missense_Mutation_p.I334T|C14orf93_uc001wia.3_Missense_Mutation_p.I334T|C14orf93_uc001wif.2_Missense_Mutation_p.I154T	NM_021944	NP_068763	Q9H972	CN093_HUMAN	hypothetical protein LOC60686 precursor	334						extracellular region				ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		CACTACTGAAATATTCCAAGA	0.418													37	96					0	0	0	0	G	23459034	G	G	23459034	3	3	38	1	0	0	0	0	1	0	0	0	1788	101	4	5	627	5	C14orf93	14	23459034	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08		23459034	83890506	71	7988											
MBIP	51562	broad.mit.edu	37	chr14	36783737	36783737	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgattacaatcaataacAttgcaaaattccctgacgtt	14	13	4	10	1	1	2	1	2	0	0	2	2	2	2	2	0	3	2	2	0	6	6			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr14:36783737A>G	uc001wtm.2	-	4	640	c.552T>C	c.(550-552)AAT>AAC	p.N184N	MBIP_uc001wto.2_Silent_p.N184N|MBIP_uc010tpy.1_Silent_p.N43N|MBIP_uc001wtn.2_Silent_p.N184N	NM_016586	NP_057670	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1 isoform 1	184	Interaction with MAP3K12.				histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		AATCAATAACATTGCAAAATT	0.279													13	44					0	0	0	0	G	36783737	G	G	36783737	2	3	38	1	0	0	0	0	0	0	0	1	9402	214	8	5		5	MBIP	14	36783737	Silent	SNP	A	TCGA-CN-4726-01A-01D-1434-08	13324703	36783737	70565803	72	7989											
SPTB	6710	broad.mit.edu	37	chr14	65262141	65262141	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtctcgagcctctggcgccGggactgcagcagctcctgca	5	7	14	15	3	2	0	0	0	2	0	4	2	3	1	3	3	5	4	3	3	0	0			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr14:65262141G>A	uc001xht.2	-	11	1612	c.1558C>T	c.(1558-1560)CGG>TGG	p.R520W	SPTB_uc001xhr.2_Missense_Mutation_p.R520W|SPTB_uc001xhs.2_Missense_Mutation_p.R520W|SPTB_uc001xhu.2_Missense_Mutation_p.R520W	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	520	Spectrin 3.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTCTGGCGCCGGGACTGCAGC	0.602													32	80					0	0	0	0	A	65262141	A	A	65262141	3	1	38	1	0	0	0	0	1	0	0	0	15184	1115	39	1	5597	1	SPTB	14	65262141	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	28478404	65262141	42087399	73	7990											
BTBD7	55727	broad.mit.edu	37	chr14	93717956	93717956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cattctaaccattcgcaagcGcacaagatccgtttgttcca	11	11	6	13	3	1	1	0	0	1	1	4	1	3	1	3	0	2	4	3	0	3	5	rs147262200	by1000genomes	TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr14:93717956G>A	uc001ybo.2	-	8	2121	c.1795C>T	c.(1795-1797)CGC>TGC	p.R599C	BTBD7_uc010aur.2_Missense_Mutation_p.R124C|BTBD7_uc010two.1_Missense_Mutation_p.R419C|BTBD7_uc001ybp.2_Missense_Mutation_p.R248C	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	599										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ATTCGCAAGCGCACAAGATCC	0.438													5	327					0	0	0	0	A	93717956	A	A	93717956	3	1	38	1	0	0	0	0	1	0	0	0	1551	1087	38	1	1619	1	BTBD7	14	93717956	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	28455815	93717956	13631584	74	7991											
CYP46A1	10858	broad.mit.edu	37	chr14	100188342	100188342	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagcatggggcacctttcGcctgctggaagaggagacct	9	7	13	12	1	0	2	0	0	0	2	1	4	0	3	4	4	2	3	4	4	1	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr14:100188342G>A	uc001ygo.2	+	12	1115	c.1115G>A	c.(1114-1116)CGC>CAC	p.R372H	CYP46A1_uc001ygp.2_Missense_Mutation_p.R219H	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	372					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GGCACCTTTCGCCTGCTGGAA	0.622													45	123					0	0	0	0	A	100188342	A	A	100188342	3	1	38	1	0	0	0	0	1	0	0	0	4199	1087	38	1	1161	1	CYP46A1	14	100188342	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	6470386	100188342	7161198	75	7992											
ALPK3	57538	broad.mit.edu	37	chr15	85384098	85384098	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgccgacgccccctgccCggcggagacatggcacccgg	6	3	15	17	5	0	1	0	0	0	1	0	3	0	1	5	5	2	1	5	5	0	0			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr15:85384098C>A	uc002ble.2	+	5	2361	c.2194C>A	c.(2194-2196)CGG>AGG	p.R732R		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	732					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCCCCTGCCCGGCGGAGACA	0.647													28	48					4.7796e-09	5.60367e-09	1	0	A	85384098	A	A	85384098	2	1	38	1	0	0	0	0	0	0	0	1	546	643	23	3		3	ALPK3	15	85384098	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08		85384098	17147294	76	7993											
CLUAP1	23059	broad.mit.edu	37	chr16	3554771	3554771	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcgacatatttctatggAaaatttccgtacacccaatt	12	13	4	12	2	1	0	0	0	1	0	3	2	2	1	3	1	1	1	3	1	6	6			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr16:3554771A>G	uc002cvk.1	+	2	179	c.74A>G	c.(73-75)GAA>GGA	p.E25G	CLUAP1_uc002cvj.1_Missense_Mutation_p.E25G|CLUAP1_uc002cvl.1_Missense_Mutation_p.E25G	NM_015041	NP_055856	Q96AJ1	CLUA1_HUMAN	clusterin associated protein 1 isoform 1	25						nucleus	protein binding			ovary(1)|breast(1)|pancreas(1)	3						ATTTCTATGGAAAATTTCCGT	0.413													23	100					0	0	0	0	G	3554771	G	G	3554771	3	3	38	1	0	0	0	0	1	0	0	0	3584	246	9	5	80	5	CLUAP1	16	3554771	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08		3554771	86799982	77	7994											
DNAH3	55567	broad.mit.edu	37	chr16	20959878	20959878	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatagtcctcctcaatttccTtacagtagaacatggacaga	14	11	6	10	0	1	2	1	0	0	2	4	3	4	3	3	1	2	1	3	1	6	4			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr16:20959878T>C	uc010vbe.1	-	57	11270	c.11270A>G	c.(11269-11271)AAG>AGG	p.K3757R	DNAH3_uc010vbd.1_Missense_Mutation_p.K1192R	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3757					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTCAATTTCCTTACAGTAGAA	0.527													3	85					0	0	0	0	C	20959878	C	C	20959878	3	2	38	1	0	0	0	0	1	0	0	0	4625	1609	56	5	1103	5	DNAH3	16	20959878	Missense_Mutation	SNP	T	TCGA-CN-4726-01A-01D-1434-08	17405107	20959878	69394875	78	7995											
ZNF768	79724	broad.mit.edu	37	chr16	30537133	30537133	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggattcaaactcagggctctGagaatctgattcagggcttc	10	11	11	9	0	5	2	3	2	2	1	6	4	5	3	0	3	1	2	0	3	2	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr16:30537133G>A	uc002dyk.3	-	2	504	c.328C>T	c.(328-330)CAG>TAG	p.Q110*	ZNF768_uc010vex.1_Nonsense_Mutation_p.Q79*|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Nonsense_Mutation_p.Q79*	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	110	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						TCAGGGCTCTGAGAATCTGAT	0.592													61	172					0	0	0	0	A	30537133	A	A	30537133	4	1	38	1	0	0	0	0	0	1	0	0	18208	1299	45	2	1298	2	ZNF768	16	30537133	Nonsense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	9577255	30537133	59817620	79	7996											
ADAMTS18	170692	broad.mit.edu	37	chr16	77387771	77387771	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctcatccactagacacccCgcctgaggtgtgctgtaatg	8	9	11	13	1	1	2	1	1	0	1	2	2	2	2	4	2	1	3	4	2	2	2	rs148669189		TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr16:77387771C>A	uc002ffc.3	-	10	1892	c.1473G>T	c.(1471-1473)GCG>GCT	p.A491A	ADAMTS18_uc010chc.1_Silent_p.A79A|ADAMTS18_uc002ffe.1_Silent_p.A187A	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	491	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CTAGACACCCCGCCTGAGGTG	0.418													57	226					2.67592e-24	3.43326e-24	1	0	A	77387771	A	A	77387771	2	1	38	1	0	0	0	0	0	0	0	1	263	639	23	3		3	ADAMTS18	16	77387771	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08	46850638	77387771	12966982	80	7997											
MAF	4094	broad.mit.edu	37	chr16	79633679	79633679	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgcactggctgatgatgcGgtcggtctccaccggttcct	4	10	13	14	4	1	2	0	2	1	0	4	2	2	2	4	4	1	3	4	4	0	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr16:79633679G>A	uc002ffn.2	-	1	944	c.121C>T	c.(121-123)CGC>TGC	p.R41C	MAF_uc002ffm.2_Missense_Mutation_p.R41C	NM_001031804	NP_001026974	O75444	MAF_HUMAN	v-maf musculoaponeurotic fibrosarcoma oncogene	41					transcription from RNA polymerase II promoter	chromatin|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_epithelial(2;0.139)|Lung NSC(2;0.186)|Melanoma(2;0.211)		UCEC - Uterine corpus endometrioid carcinoma (2;0.0178)		CTGATGATGCGGTCGGTCTCC	0.607			T	IGH@	MM								19	55					0	0	0	0	A	79633679	A	A	79633679	3	1	38	1	0	0	0	0	1	0	0	0	9206	1116	39	1	1102	1	MAF	16	79633679	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	2245908	79633679	10721074	81	7998											
CDYL2	124359	broad.mit.edu	37	chr16	80646543	80646543	+	Frame_Shift_Del	DEL	G	-	-																															cagcgcgacgcccaggatctGggggaaggtgtaggaggagc																										TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr16:80646543delG	uc002ffs.2	-	5	1303	c.1198delC	c.(1198-1200)CAGfs	p.Q400fs		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	400						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						CCCAGGATCTGGGGGAAGGTG	0.627													---	---	---								-	80646543	-	-	80646543	7	5	38	1	0	1	0	1	0	0	0	0	3201	1357	47	0	334	0	CDYL2	16	80646543	Frame_Shift_Del	DEL	G	TCGA-CN-4726-01A-01D-1434-08	1012864	80646543	9708210	82	7999											
TP53	7157	broad.mit.edu	37	chr17	7579310	7579310	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcccctcagggcaactgAccgtgcaagtcacagacttg	10	6	10	15	1	2	2	2	1	0	1	2	2	2	2	4	1	3	2	4	1	2	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr17:7579310A>T	uc002gim.2	-	4	569	c.375_splice	c.e4+1	p.T125_splice	TP53_uc002gig.1_Splice_Site_p.T125_splice|TP53_uc002gih.2_Splice_Site_p.T125_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Splice_Site_p.T125_splice|TP53_uc010cni.1_Splice_Site_p.T125_splice|TP53_uc002gij.2_Splice_Site_p.T125_splice|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Splice_Site_p.T86_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(5)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGGCAACTGACCGTGCAAGT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			56	81					0	0	0	0	T	7579310	T	T	7579310	5	4	38	1	0	0	0	0	0	0	1	0	16448	289	10	5	925	5	TP53	17	7579310	Splice_Site	SNP	A	TCGA-CN-4726-01A-01D-1434-08		7579310	73615900	83	8000											
SLFN13	146857	broad.mit.edu	37	chr17	33772744	33772744	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaatatttgtttcatttttGattaaaaaattgttacaggc	14	18	6	3	0	1	2	1	1	0	1	1	2	1	2	0	1	1	2	0	1	6	8			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr17:33772744G>C	uc002hjk.1	-	1	286	c.-44C>G	c.(-46--42)ATCAA>ATGAA		SLFN13_uc010wch.1_Intron|SLFN13_uc002hjl.2_Intron|SLFN13_uc010ctt.2_Intron|SLFN13_uc002hjm.2_Intron	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13							intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TTTCATTTTTGATTAAAAAAT	0.244													5	15					0	0	0	0	C	33772744	C	C	33772744	1	2	38	1	0	0	0	0	0	0	0	0	14800	1305	45	2		2	SLFN13	17	33772744	Translation_Start_Site	SNP	G	TCGA-CN-4726-01A-01D-1434-08	26193434	33772744	47422466	84	8001											
GPR179	440435	broad.mit.edu	37	chr17	36485440	36485440	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgattctgccagggtcctGaggagctgacccaggggaca	8	8	14	11	0	2	3	0	3	2	0	3	5	3	5	3	4	2	1	3	4	0	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr17:36485440G>A	uc002hpz.2	-	11	4033	c.4012C>T	c.(4012-4014)CAG>TAG	p.Q1338*		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1338	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCAGGGTCCTGAGGAGCTGAC	0.612													36	134					0	0	0	0	A	36485440	A	A	36485440	4	1	38	1	0	0	0	0	0	1	0	0	6712	1299	45	2	3095	2	GPR179	17	36485440	Nonsense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08	2712696	36485440	44709770	85	8002											
PRKAR1A	5573	broad.mit.edu	37	chr17	66518980	66518980	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatttctcctcctccaccCaacccagtggttaaaggtag	10	10	8	13	0	1	1	0	0	1	1	4	2	3	1	5	2	1	2	5	2	4	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr17:66518980C>A	uc002jhg.2	+	3	441	c.261C>A	c.(259-261)CCC>CCA	p.P87P	PRKAR1A_uc002jhh.2_Silent_p.P87P|PRKAR1A_uc002jhi.2_Silent_p.P87P|PRKAR1A_uc002jhj.2_Silent_p.P87P|PRKAR1A_uc002jhk.2_5'UTR|PRKAR1A_uc002jhl.2_Silent_p.P87P|PRKAR1A_uc002jhm.2_Silent_p.P87P	NM_212471	NP_997636	P10644	KAP0_HUMAN	cAMP-dependent protein kinase, regulatory	87	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|lung(3)|thyroid(2)|soft_tissue(2)|breast(1)	12	Breast(10;1.64e-13)					CTCCTCCACCCAACCCAGTGG	0.488			T|Mis|N|F|S	RET	papillary thyroid	myxoma|endocrine|papillary thyroid			Carney_Complex|Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial|Cardiac_Myxomas_Familial_Clustering_of				4	126					0.000602214	0.000676869	1	0	A	66518980	A	A	66518980	2	1	38	1	0	0	0	0	0	0	0	1	12565	581	21	4		4	PRKAR1A	17	66518980	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08	30033540	66518980	14676230	86	8003											
ABCA5	23461	broad.mit.edu	37	chr17	67310534	67310534	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtctgtctccaaactcctAcctccctaattgcagtggac	8	12	7	14	0	2	0	0	0	2	0	5	1	4	1	4	2	3	1	4	2	3	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr17:67310534A>G	uc002jif.2	-	1	1241	c.23T>C	c.(22-24)GTA>GCA	p.V8A	ABCA5_uc002jig.2_Missense_Mutation_p.V8A|ABCA5_uc002jih.2_Missense_Mutation_p.V8A|ABCA5_uc010dfe.2_Missense_Mutation_p.V8A	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	8					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					CCAAACTCCTACCTCCCTAAT	0.358													5	208					0	0	0	0	G	67310534	G	G	67310534	3	3	38	1	0	0	0	0	1	0	0	0	35	391	14	5	5057	5	ABCA5	17	67310534	Missense_Mutation	SNP	A	TCGA-CN-4726-01A-01D-1434-08	791554	67310534	13884676	87	8004											
CABLES1	91768	broad.mit.edu	37	chr18	20833900	20833900	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtcaagcatttaattgaCgtaagtagcctttttcctgg	11	14	9	7	1	1	1	1	1	0	0	2	2	2	1	2	1	2	3	2	1	5	7			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr18:20833900C>T	uc002kuc.2	+	9	1761	c.1761C>T	c.(1759-1761)GAC>GAT	p.D587D	C18orf45_uc010xaq.1_Intron|CABLES1_uc002kub.2_Silent_p.D90D|CABLES1_uc002kud.2_Silent_p.D322D	NM_001100619	NP_001094089	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1 isoform 2	587					blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)	1	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ATTTAATTGACGTAAGTAGCC	0.507													19	60					0	0	0	0	T	20833900	T	T	20833900	2	4	38	1	0	0	0	0	0	0	0	1	2541	550	19	1		1	CABLES1	18	20833900	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08		20833900	57243348	88	8005											
C18orf8	29919	broad.mit.edu	37	chr18	21098936	21098936	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggaggtggtcctctatcatCtaccacggtagatttcatgc	8	12	10	11	2	4	1	2	0	2	1	5	2	5	2	2	4	2	1	2	4	3	4			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr18:21098936C>T	uc010xax.1	+	8	857	c.736C>T	c.(736-738)CTA>TTA	p.L246L	C18orf8_uc010xau.1_Silent_p.L89L|C18orf8_uc010xav.1_Silent_p.L198L|C18orf8_uc010xaw.1_Silent_p.L89L|C18orf8_uc002kul.2_RNA	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	246										ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCTCTATCATCTACCACGGTA	0.433													29	101					0	0	0	0	T	21098936	T	T	21098936	2	4	38	1	0	0	0	0	0	0	0	1	1916	912	32	2		2	C18orf8	18	21098936	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08	265036	21098936	56978312	89	8006											
GTF2F1	2962	broad.mit.edu	37	chr19	6389470	6389470	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cttacttcctgcctgatttgCcgttgacccggagcagccag	6	11	10	14	2	0	2	0	2	0	0	1	3	1	3	5	1	5	2	5	1	1	4			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr19:6389470C>T	uc002meq.2	-	4	596	c.311G>A	c.(310-312)GGC>GAC	p.G104D	GTF2F1_uc010xjb.1_5'Flank|GTF2F1_uc010xjc.1_Missense_Mutation_p.G76D	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	104					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						GCCTGATTTGCCGTTGACCCG	0.612													4	279					0	0	0	0	T	6389470	T	T	6389470	3	4	38	1	0	0	0	0	1	0	0	0	6897	739	26	4	1282	4	GTF2F1	19	6389470	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08		6389470	52739513	90	8007											
MUC16	94025	broad.mit.edu	37	chr19	9059514	9059514	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtagcaccagtgggcacaCtagaaaggacagtgcttttt	12	10	11	8	0	0	1	0	0	0	1	0	2	0	2	1	2	2	4	1	2	4	5			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr19:9059514C>A	uc002mkp.2	-	3	28136	c.27932G>T	c.(27931-27933)AGT>ATT	p.S9311I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9313	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTGGGCACACTAGAAAGGAC	0.498													5	275					0.000602214	0.000676869	1	0	A	9059514	A	A	9059514	3	1	38	1	0	0	0	0	1	0	0	0	10026	565	20	4	15919	4	MUC16	19	9059514	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	2670044	9059514	50069469	91	8008											
CACNA1A	773	broad.mit.edu	37	chr19	13366020	13366020	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggaagctctgcttgttctgCggcatgtgtcgggtcagcgg	4	12	16	9	3	3	0	1	0	2	0	4	1	3	1	0	4	4	4	0	4	1	2			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr19:13366020C>A	uc010dze.2	-	29	4883	c.4647G>T	c.(4645-4647)CCG>CCT	p.P1549P	CACNA1A_uc010xnd.1_Silent_p.P254P|CACNA1A_uc002mwx.3_Silent_p.P254P|CACNA1A_uc010dzc.2_Silent_p.P1074P|CACNA1A_uc002mwy.3_Silent_p.P1548P|CACNA1A_uc010xne.1_Silent_p.P1077P|CACNA1A_uc002mwv.3_Silent_p.P65P	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1549	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCTTGTTCTGCGGCATGTGTC	0.607													3	38					0.004672	0.00516579	1	0	A	13366020	A	A	13366020	2	1	38	1	0	0	0	0	0	0	0	1	2550	755	27	3		3	CACNA1A	19	13366020	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08	4306506	13366020	45762963	92	8009											
SLC7A10	56301	broad.mit.edu	37	chr19	33717095	33717104	+	5'Flank	DEL	TGTGTGTGTG	-	-																															agtactctatgcctgcacgaTgtgtgtgtgtgtgtgtgtgt																								rs3064210		TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr19:33717095_33717104delTGTGTGTGTG	uc002num.2	-						SLC7A10_uc010xrq.1_5'Flank	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10						blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					GCCTGCACGAtgtgtgtgtgtgtgtgtgtg	0.357													---	---	---								-	33717104	-	-	33717095	6	5	38	0	1	1	0	1	0	0	0	0	14757	1479	51	0		0	SLC7A10	19	33717095	5'Flank	DEL	TGTGTGTGTG	TCGA-CN-4726-01A-01D-1434-08	20351075	33717095	25411888	93	8010											
ZNF222	7673	broad.mit.edu	37	chr19	44536829	44536829	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttttggtccatcaacgagtCcacactggagaaaagccata	13	9	8	11	1	1	1	1	0	0	1	3	3	3	1	3	2	2	0	3	2	4	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr19:44536829C>G	uc002oyc.2	+	4	1185	c.1002C>G	c.(1000-1002)GTC>GTG	p.V334V	ZNF284_uc010ejd.2_Intron|ZNF222_uc002oye.2_Silent_p.V374V|ZNF222_uc002oyd.2_Silent_p.V280V	NM_013360	NP_037492	Q9UK12	ZN222_HUMAN	zinc finger protein 222 isoform 2	334	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Prostate(69;0.0435)				ATCAACGAGTCCACACTGGAG	0.428													48	194					0	0	0	0	G	44536829	G	G	44536829	2	3	38	1	0	0	0	0	0	0	0	1	17843	842	30	2		2	ZNF222	19	44536829	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08	10819734	44536829	14592154	94	8011											
TBC1D20	128637	broad.mit.edu	37	chr20	419364	419364	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggttggtccttggcttggTcaggacatcttttgttcgat	4	16	13	8	2	2	0	1	0	1	0	4	2	3	1	1	5	0	3	1	5	0	6			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr20:419364T>A	uc002wds.2	-	8	1216	c.1078A>T	c.(1078-1080)ACC>TCC	p.T360S	TBC1D20_uc002wdv.2_Missense_Mutation_p.T183S|TBC1D20_uc002wdt.2_RNA|TBC1D20_uc002wdu.2_RNA	NM_144628	NP_653229	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	360					interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)	1		all_epithelial(17;0.228)|Breast(17;0.231)				CTTGGCTTGGTCAGGACATCT	0.567													91	227					0	0	0	0	A	419364	A	A	419364	3	1	38	1	0	0	0	0	1	0	0	0	15675	1667	58	5	137	5	TBC1D20	20	419364	Missense_Mutation	SNP	T	TCGA-CN-4726-01A-01D-1434-08		419364	62606156	95	8012											
GCAT	23464	broad.mit.edu	37	chr22	38212212	38212212	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accttgtgcccacaggttccGtagtaagatggaagctgctg	9	10	12	10	1	0	1	0	0	0	1	1	2	1	2	3	2	3	5	3	2	3	4			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chr22:38212212G>A	uc003atz.2	+	8	1012	c.992G>A	c.(991-993)CGT>CAT	p.R331H	GCAT_uc003aua.1_Missense_Mutation_p.R357H	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	331					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CACAGGTTCCGTAGTAAGATG	0.612													26	60					0	0	0	0	A	38212212	A	A	38212212	3	1	38	1	0	0	0	0	1	0	0	0	6319	1145	40	1	1100	1	GCAT	22	38212212	Missense_Mutation	SNP	G	TCGA-CN-4726-01A-01D-1434-08		38212212	13092354	96	8013											
XIAP	331	broad.mit.edu	37	chrX	123040864	123040864	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactgaagagcagctaaggCgcctgcaagaggagaagctt	13	6	14	8	1	0	4	0	1	0	3	0	5	0	4	1	2	5	5	1	2	5	3			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chrX:123040864C>T	uc010nqu.2	+	7	1453	c.1327C>T	c.(1327-1329)CGC>TGC	p.R443C	XIAP_uc004etx.2_Missense_Mutation_p.R443C|XIAP_uc010nqv.2_Missense_Mutation_p.R69C	NM_001167	NP_001158	P98170	XIAP_HUMAN	baculoviral IAP repeat-containing protein 4	443					anti-apoptosis|apoptosis|induction of apoptosis by intracellular signals|response to DNA damage stimulus	cytosol	caspase inhibitor activity|ligase activity|protein binding|zinc ion binding			ovary(1)|lung(1)	2						GCAGCTAAGGCGCCTGCAAGA	0.323									X-linked_Lymphoproliferative_syndrome				37	33					0	0	0	0	T	123040864	T	T	123040864	3	4	38	1	0	0	0	0	1	0	0	0	17496	768	27	1	1349	1	XIAP	23	123040864	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08		123040864	32229696	97	8014											
DCAF12L1	139170	broad.mit.edu	37	chrX	125685920	125685920	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtgtcatcgaacttgtcCgggtccatccgccacagcgc	8	8	10	15	4	1	0	1	0	0	0	5	1	4	0	4	1	2	0	4	1	1	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chrX:125685920C>T	uc004eul.2	-	1	923	c.672G>A	c.(670-672)CCG>CCA	p.P224P		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	224	WD 2.									skin(3)|ovary(1)	4						CGAACTTGTCCGGGTCCATCC	0.642													33	33					0	0	0	0	T	125685920	T	T	125685920	2	4	38	1	0	0	0	0	0	0	0	1	4281	639	23	1		1	DCAF12L1	23	125685920	Silent	SNP	C	TCGA-CN-4726-01A-01D-1434-08	2645056	125685920	29584640	98	8015											
ARHGAP36	158763	broad.mit.edu	37	chrX	130215772	130215772	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaggacacaaccccgacCgcaggacgaagatggtatcg	12	3	11	15	4	0	1	0	0	0	1	1	5	0	3	5	3	1	2	5	3	3	1			TCGA-CN-4726-01A-01D-1434-08	TCGA-CN-4726-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	2201e681-a727-4fd2-adec-cbcb543b2232	8aec558c-7b7e-47dd-b84f-db6dabacbd12	g.chrX:130215772C>G	uc004evz.2	+	2	478	c.133C>G	c.(133-135)CGC>GGC	p.R45G	ARHGAP36_uc004ewa.2_Missense_Mutation_p.R33G|ARHGAP36_uc004ewb.2_Missense_Mutation_p.R14G|ARHGAP36_uc004ewc.2_5'Flank	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	45					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						CAACCCCGACCGCAGGACGAA	0.547													73	143					0	0	0	0	G	130215772	G	G	130215772	3	3	38	1	0	0	0	0	1	0	0	0	883	652	23	3	135	3	ARHGAP36	23	130215772	Missense_Mutation	SNP	C	TCGA-CN-4726-01A-01D-1434-08	4529852	130215772	25054788	99	8016											
AGRN	375790	broad.mit.edu	37	chr1	979269	979269	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggcagtgtgtgtgtccccGgtgtgagcaccccccgcccg	4	7	15	15	3	0	1	0	1	0	0	1	1	1	1	6	2	1	2	6	2	0	0	rs140789461		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:979269G>T	uc001ack.1	+	10	1915	c.1865G>T	c.(1864-1866)CGG>CTG	p.R622L		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	622	Kazal-like 7.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GTGTGTCCCCGGTGTGAGCAC	0.682													6	51					3.59834e-05	3.85586e-05	1	0	T	979269	T	T	979269	3	4	39	1	0	0	0	0	1	0	0	0	397	1116	39	3	1903	3	AGRN	1	979269	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08		979269	248271352	1	8017											
TAS1R3	83756	broad.mit.edu	37	chr1	1267466	1267466	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttcccctccttcttccgCaccgtgcccagcgaccgtgt	4	10	7	20	4	1	0	0	0	1	0	4	1	4	0	8	0	2	1	8	0	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:1267466C>A	uc010nyk.1	+	3	555	c.555C>A	c.(553-555)CGC>CGA	p.R185R		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	185	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CCTTCTTCCGCACCGTGCCCA	0.682													35	70					7.04047e-22	9.67847e-22	1	0	A	1267466	A	A	1267466	2	1	39	1	0	0	0	0	0	0	0	1	15630	697	25	4		4	TAS1R3	1	1267466	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	288197	1267466	247983155	2	8018											
SPEN	23013	broad.mit.edu	37	chr1	16255029	16255029	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcctcagaccggagtggaaGctgtagctcactctcccctc	8	9	9	15	1	3	1	2	0	1	1	6	3	4	3	4	2	2	3	4	2	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:16255029G>A	uc001axk.1	+	11	2498	c.2294G>A	c.(2293-2295)AGC>AAC	p.S765N	SPEN_uc010obp.1_Missense_Mutation_p.S724N	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	765	Arg-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CGGAGTGGAAGCTGTAGCTCA	0.498													21	93					0	0	0	0	A	16255029	A	A	16255029	3	1	39	1	0	0	0	0	1	0	0	0	15104	971	34	4	2336	4	SPEN	1	16255029	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	14987563	16255029	232995592	3	8019											
RUNX3	864	broad.mit.edu	37	chr1	25254161	25254161	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcagcggagtagttctCgtcattgcctgccatcacag	8	10	10	13	2	4	0	3	0	1	0	5	1	4	1	2	1	4	3	2	1	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:25254161C>A	uc001bjq.2	-	2	754	c.343G>T	c.(343-345)GAG>TAG	p.E115*	RUNX3_uc010oen.1_Nonsense_Mutation_p.E115*|RUNX3_uc009vrj.2_Nonsense_Mutation_p.E129*|RUNX3_uc001bjr.2_Nonsense_Mutation_p.E129*	NM_004350	NP_004341	Q13761	RUNX3_HUMAN	runt-related transcription factor 3 isoform 2	115	Runt.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		GAGTAGTTCTCGTCATTGCCT	0.627													78	203					1.40941e-23	1.98175e-23	1	0	A	25254161	A	A	25254161	4	1	39	1	0	0	0	0	0	1	0	0	13814	893	31	3	920	3	RUNX3	1	25254161	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	8999132	25254161	223996460	4	8020											
YTHDF2	51441	broad.mit.edu	37	chr1	29095450	29095450	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacctctgtaggaacgtcaaGgtcgtgggaaataaaaggca	14	8	12	7	2	2	0	1	0	1	0	3	2	2	2	1	4	2	2	1	4	7	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:29095450G>A	uc001brc.2	+	5	2223	c.1726G>A	c.(1726-1728)GGT>AGT	p.G576S	YTHDF2_uc001brd.2_Missense_Mutation_p.G573S|YTHDF2_uc010ofx.1_Missense_Mutation_p.G526S|YTHDF2_uc001bre.2_Missense_Mutation_p.G526S	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	576					humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		GGAACGTCAAGGTCGTGGGAA	0.343													8	63					0	0	0	0	A	29095450	A	A	29095450	3	1	39	1	0	0	0	0	1	0	0	0	17567	1000	35	4	1744	4	YTHDF2	1	29095450	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	3841289	29095450	220155171	5	8021											
PHC2	1912	broad.mit.edu	37	chr1	33832992	33832992	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggggcccgaggctgctgccGctggtgtctgctgtgttcgg	1	11	18	11	3	1	0	0	0	1	0	2	1	1	0	2	5	3	5	2	5	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:33832992G>A	uc001bxg.1	-	6	755	c.701C>T	c.(700-702)GCG>GTG	p.A234V	PHC2_uc001bxh.1_Missense_Mutation_p.A205V|PHC2_uc009vuh.1_Missense_Mutation_p.A234V|PHC2_uc001bxi.1_Missense_Mutation_p.A234V	NM_198040	NP_932157	Q8IXK0	PHC2_HUMAN	polyhomeotic-like 2 isoform a	234					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGCTGCTGCCGCTGGTGTCTG	0.622											OREG0013344	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	74	153					0	0	0	0	A	33832992	A	A	33832992	3	1	39	1	0	0	0	0	1	0	0	0	11872	1087	38	1	1911	1	PHC2	1	33832992	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4737542	33832992	215417629	6	8022											
DLGAP3	58512	broad.mit.edu	37	chr1	35350638	35350638	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccctccggctcctgttctcGgtgtccgaatctgagatcgt	4	13	10	14	4	2	1	0	1	2	1	8	3	6	1	4	2	0	2	4	2	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:35350638G>C	uc001byc.2	-	6	1941	c.1941C>G	c.(1939-1941)ACC>ACG	p.T647T		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	647					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				TCCTGTTCTCGGTGTCCGAAT	0.607													33	68					0	0	0	0	C	35350638	C	C	35350638	2	2	39	1	0	0	0	0	0	0	0	1	4583	1103	39	3		3	DLGAP3	1	35350638	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1517646	35350638	213899983	7	8023											
CSF3R	1441	broad.mit.edu	37	chr1	36933736	36933736	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgggtaagggggctcttccCcagctcagggggctcaggca	6	7	17	11	0	3	0	2	0	1	0	4	0	4	0	2	6	1	5	2	6	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:36933736C>G	uc001caw.1	-	13	1841	c.1663G>C	c.(1663-1665)GGG>CGG	p.G555R	CSF3R_uc001cat.1_Missense_Mutation_p.G118R|CSF3R_uc009vvc.1_Missense_Mutation_p.G84R|CSF3R_uc001cau.1_5'UTR|CSF3R_uc001cav.1_Missense_Mutation_p.G555R|CSF3R_uc001cax.1_Missense_Mutation_p.G555R|CSF3R_uc001cay.1_Missense_Mutation_p.G555R	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	555	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	GGGCTCTTCCCCAGCTCAGGG	0.592													42	82					0	0	0	0	G	36933736	G	G	36933736	3	3	39	1	0	0	0	0	1	0	0	0	3954	623	22	4	1057	4	CSF3R	1	36933736	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1583098	36933736	212316885	8	8024											
DMAP1	55929	broad.mit.edu	37	chr1	44685699	44685699	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcctgcagagctgagcccGacacctacggaggagctggt	8	6	14	13	2	0	2	0	1	0	1	0	5	0	4	3	3	6	3	3	3	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:44685699G>A	uc001clq.1	+	10	1142	c.1062G>A	c.(1060-1062)CCG>CCA	p.P354P	DMAP1_uc001clr.1_Silent_p.P354P|DMAP1_uc001cls.1_Silent_p.P354P|DMAP1_uc010oku.1_Silent_p.P344P	NM_001034024	NP_001029196	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	354					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					AGCTGAGCCCGACACCTACGG	0.622													7	42					0	0	0	0	A	44685699	A	A	44685699	2	1	39	1	0	0	0	0	0	0	0	1	4598	1045	37	1		1	DMAP1	1	44685699	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	7751963	44685699	204564922	9	8025											
KIAA0494	9813	broad.mit.edu	37	chr1	47154099	47154100	+	Frame_Shift_Ins	INS	-	CTGGGTAAGATTA	CTGGGTAAGATTA																															ctttctatcaggttgactctINSctgggtaagattactgactg																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:47154099_47154100insCTGGGTAAGATTA	uc001cqk.3	-	7	1889_1890	c.912_913insTAATCTTACCCAG	c.(910-915)CAGAGAfs	p.Q304fs	KIAA0494_uc010omh.1_Intron|KIAA0494_uc010omj.1_Intron|KIAA0494_uc001cql.1_Frame_Shift_Ins_p.Q304fs	NM_014774	NP_055589	O75071	K0494_HUMAN	hypothetical protein LOC9813	304_305							calcium ion binding				0	Acute lymphoblastic leukemia(166;0.155)					AGGTTGACTCTCTGGGTAAGAT	0.441													---	---	---								CTGGGTAAGATTA	47154100	CTGGGTAAGATTA	CTGGGTAAGATTA	47154099	7	5	39	1	0	1	1	0	0	0	0	0	8218	1559	54	0	594	0	KIAA0494	1	47154099	Frame_Shift_Ins	INS	-	TCGA-CN-4727-01A-01D-1434-08	2468400	47154099	202096522	10	8026											
TTC39A	22996	broad.mit.edu	37	chr1	51768088	51768088	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaagaacaggaagatggcacCctgcaatgacacacatgtaa	18	5	9	9	0	0	3	0	1	0	2	0	4	0	4	1	2	2	3	1	2	5	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:51768088C>A	uc001csl.2	-	11	1045	c.940G>T	c.(940-942)GGT>TGT	p.G314C	TTC39A_uc001csk.2_Missense_Mutation_p.G279C|TTC39A_uc010ond.1_Missense_Mutation_p.G251C|TTC39A_uc010one.1_Missense_Mutation_p.G278C|TTC39A_uc010onf.1_Missense_Mutation_p.G282C|TTC39A_uc001csn.2_Missense_Mutation_p.G313C|TTC39A_uc001cso.1_Missense_Mutation_p.G310C|TTC39A_uc009vyy.1_Missense_Mutation_p.G251C	NM_001080494	NP_001073963	Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A isoform 2	314							binding			skin(1)	1						AAGATGGCACCCTGCAATGAC	0.592													3	23					2.56e-06	2.78086e-06	1	0	A	51768088	A	A	51768088	3	1	39	1	0	0	0	0	1	0	0	0	16775	637	22	4	933	4	TTC39A	1	51768088	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4613989	51768088	197482533	11	8027											
DAB1	1600	broad.mit.edu	37	chr1	57528566	57528566	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatgtacttacacttacaggTtgactttttggcacatcata	11	15	7	8	0	1	1	1	1	0	0	1	2	1	1	0	2	3	3	0	2	4	7	rs148730065	by1000genomes	TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:57528566T>A	uc001cys.1	-	11	1388	c.714A>T	c.(712-714)CAA>CAT	p.Q238H	DAB1_uc001cyt.1_Missense_Mutation_p.Q238H|DAB1_uc001cyq.1_Missense_Mutation_p.Q203H|DAB1_uc001cyr.1_Missense_Mutation_p.Q119H|DAB1_uc009vzw.1_Missense_Mutation_p.Q203H|DAB1_uc009vzx.1_Missense_Mutation_p.Q238H	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	238					cell differentiation|nervous system development					skin(2)|ovary(1)	3						CACTTACAGGTTGACTTTTTG	0.463													24	90					0	0	0	0	A	57528566	A	A	57528566	3	1	39	1	0	0	0	0	1	0	0	0	4234	1722	60	5	977	5	DAB1	1	57528566	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	5760478	57528566	191722055	12	8028											
C1orf87	127795	broad.mit.edu	37	chr1	60463339	60463339	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agcttcctgaacctgtctatCcacgtctcacattcctcagc	8	12	5	16	1	3	1	2	1	2	0	7	1	6	1	4	0	3	1	4	0	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:60463339C>G	uc001czs.1	-	11	1514	c.1422G>C	c.(1420-1422)TGG>TGC	p.W474C	C1orf87_uc001czr.1_Missense_Mutation_p.W66C	NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	474							calcium ion binding			ovary(1)|breast(1)	2						ACCTGTCTATCCACGTCTCAC	0.468													39	91					0	0	0	0	G	60463339	G	G	60463339	3	3	39	1	0	0	0	0	1	0	0	0	2074	856	30	2	226	2	C1orf87	1	60463339	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2934773	60463339	188787282	13	8029											
IL12RB2	3595	broad.mit.edu	37	chr1	67861485	67861485	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaactggtggatctgtacAaggtgctggagagcaggggc	10	7	17	7	0	1	1	0	0	1	1	1	4	1	2	0	6	4	3	0	6	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:67861485A>G	uc001ddu.2	+	16	2942	c.2302A>G	c.(2302-2304)AAG>GAG	p.K768E	IL12RB2_uc010oqi.1_3'UTR|IL12RB2_uc010oqj.1_3'UTR|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.K682E|IL12RB2_uc010oqm.1_3'UTR|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	768	Cytoplasmic (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						GGATCTGTACAAGGTGCTGGA	0.582													39	123					0	0	0	0	G	67861485	G	G	67861485	3	3	39	1	0	0	0	0	1	0	0	0	7666	131	5	5	2360	5	IL12RB2	1	67861485	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	7398146	67861485	181389136	14	8030											
SERBP1	26135	broad.mit.edu	37	chr1	67891881	67891881	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttttcgaatcttcgttcaCgaggtggtcgcctttctggt	4	16	11	10	4	3	0	1	0	2	0	6	2	3	0	1	3	0	2	1	3	1	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:67891881C>A	uc001ddv.2	-	2	541	c.401G>T	c.(400-402)CGT>CTT	p.R134L	SERBP1_uc001ddx.2_Missense_Mutation_p.R134L|SERBP1_uc001ddy.2_Missense_Mutation_p.R134L|SERBP1_uc001ddw.2_Missense_Mutation_p.R134L	NM_001018067	NP_001018077	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1 isoform 1	134					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			skin(1)	1						TCTTCGTTCACGAGGTGGTCG	0.358													114	282					9.6197e-41	1.47219e-40	1	0	A	67891881	A	A	67891881	3	1	39	1	0	0	0	0	1	0	0	0	14140	536	19	3	853	3	SERBP1	1	67891881	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	30396	67891881	181358740	15	8031											
TNNI3K	51086	broad.mit.edu	37	chr1	74833001	74833001	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccacaagatgaattgccctgTaatgaatattctcagcctgg	12	11	8	10	0	1	3	1	2	1	1	2	3	1	3	3	1	2	1	3	1	5	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:74833001T>C	uc001dgf.1	+	12	1290	c.1239T>C	c.(1237-1239)TGT>TGC	p.C413C	TNNI3K_uc001dgc.1_Silent_p.C514C|TNNI3K_uc001dgd.2_Silent_p.C514C|TNNI3K_uc001dge.1_Silent_p.C514C	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	413						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						AATTGCCCTGTAATGAATATT	0.358													60	139					0	0	0	0	C	74833001	C	C	74833001	2	2	39	1	0	0	0	0	0	0	0	1	16395	1644	57	5		5	TNNI3K	1	74833001	Silent	SNP	T	TCGA-CN-4727-01A-01D-1434-08	6941120	74833001	174417620	16	8032											
IFI44L	10964	broad.mit.edu	37	chr1	79093997	79093997	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagataataaaatttatctaGataaaatgataacaagaaac	23	10	5	3	0	1	4	0	1	1	3	1	5	1	4	0	0	2	0	0	0	10	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:79093997G>T	uc010oro.1	+	2	576	c.397G>T	c.(397-399)GAT>TAT	p.D133Y	IFI44L_uc010orp.1_Intron|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	133						cytoplasm					0						AATTTATCTAGATAAAATGAT	0.299													15	42					2.31682e-05	2.48744e-05	1	0	T	79093997	T	T	79093997	3	4	39	1	0	0	0	0	1	0	0	0	7557	942	33	2	399	2	IFI44L	1	79093997	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4260996	79093997	170156624	17	8033											
DBT	1629	broad.mit.edu	37	chr1	100672035	100672035	+	Frame_Shift_Del	DEL	G	-	-																															aaagagtaaatgttcctcctGtaagatcagtggtgctgagc																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:100672035delG	uc001dta.2	-	9	1208	c.1175delC	c.(1174-1176)ACAfs	p.T392fs	DBT_uc010oug.1_Frame_Shift_Del_p.T211fs	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	392					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TGTTCCTCCTGTAAGATCAGT	0.378													---	---	---								-	100672035	-	-	100672035	7	5	39	1	0	1	0	1	0	0	0	0	4275	1377	48	0	285	0	DBT	1	100672035	Frame_Shift_Del	DEL	G	TCGA-CN-4727-01A-01D-1434-08	21578038	100672035	148578586	18	8034											
OLFM3	118427	broad.mit.edu	37	chr1	102312602	102312602	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggcagcgggaggcgtgaCtgcagcgcgccacatctaca	8	5	15	13	4	1	1	0	1	1	0	1	2	1	2	1	3	4	3	1	3	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:102312602C>G	uc001duf.2	-	1	1	c.-70_splice	c.e1-1		OLFM3_uc001dug.2_Intron|OLFM3_uc001duh.2_Intron|OLFM3_uc001dui.2_Intron|OLFM3_uc001duj.2_Intron|OLFM3_uc001due.2_Splice_Site	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3							extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		GGAGGCGTGACTGCAGCGCGC	0.552													11	38					0	0	0	0	G	102312602	G	G	102312602	5	3	39	1	0	0	0	0	0	0	1	0	10908	580	20	4		4	OLFM3	1	102312602	Splice_Site	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1640567	102312602	146938019	19	8035											
COL11A1	1301	broad.mit.edu	37	chr1	103381240	103381240	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccctgcttctccaggttcacCctatatagagaagatcaaat	12	11	6	12	0	3	2	2	0	1	2	4	3	3	2	3	1	1	2	3	1	5	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:103381240C>A	uc001dul.2	-	50	4081	c.3763G>T	c.(3763-3765)GGT>TGT	p.G1255C	COL11A1_uc001duk.2_Missense_Mutation_p.G451C|COL11A1_uc001dum.2_Missense_Mutation_p.G1267C|COL11A1_uc001dun.2_Missense_Mutation_p.G1216C|COL11A1_uc009weh.2_Missense_Mutation_p.G1139C	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1255	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCAGGTTCACCCTATATAGAG	0.353													70	114					1.70537e-16	2.20742e-16	1	0	A	103381240	A	A	103381240	3	1	39	1	0	0	0	0	1	0	0	0	3682	637	22	4	1729	4	COL11A1	1	103381240	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1068638	103381240	145869381	20	8036											
COL11A1	1301	broad.mit.edu	37	chr1	103480115	103480115	+	Frame_Shift_Del	DEL	G	-	-																															tgagcttcctgagcagagatGgttggtcctttggaaccatc																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:103480115delG	uc001dul.2	-	13	1842	c.1524delC	c.(1522-1524)ACCfs	p.T508fs	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Frame_Shift_Del_p.T520fs|COL11A1_uc001dun.2_Frame_Shift_Del_p.T469fs|COL11A1_uc009weh.2_Frame_Shift_Del_p.T392fs	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	508	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GAGCAGAGATGGTTGGTCCTT	0.418													---	---	---								-	103480115	-	-	103480115	7	5	39	1	0	1	0	1	0	0	0	0	3682	1335	47	0	4116	0	COL11A1	1	103480115	Frame_Shift_Del	DEL	G	TCGA-CN-4727-01A-01D-1434-08	98875	103480115	145770506	21	8037											
COL11A1	1301	broad.mit.edu	37	chr1	103488414	103488414	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatcatattcgcctaaatCtccatctaccagaagatcag	16	10	4	11	1	4	2	2	0	2	2	6	2	4	2	3	0	1	0	3	0	7	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:103488414C>A	uc001dul.2	-	8	1447	c.1129G>T	c.(1129-1131)GAT>TAT	p.D377Y	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.D389Y|COL11A1_uc001dun.2_Missense_Mutation_p.D338Y|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	377	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCGCCTAAATCTCCATCTACC	0.378													28	139					4.87955e-14	6.12987e-14	1	0	A	103488414	A	A	103488414	3	1	39	1	0	0	0	0	1	0	0	0	3682	913	32	2	4531	2	COL11A1	1	103488414	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	8299	103488414	145762207	22	8038											
NOTCH2	4853	broad.mit.edu	37	chr1	120462937	120462937	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgatggtgtcctacggatGtctgcagcttcaaggtgctg	7	11	14	9	2	2	0	1	0	1	0	3	2	3	1	1	3	5	3	1	3	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:120462937G>C	uc001eik.2	-	30	5650	c.5394C>G	c.(5392-5394)GAC>GAG	p.D1798E		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1798	Cytoplasmic (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCCTACGGATGTCTGCAGCTT	0.557			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				50	86					0	0	0	0	C	120462937	C	C	120462937	3	2	39	1	0	0	0	0	1	0	0	0	10602	1368	48	4	2041	4	NOTCH2	1	120462937	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	16974523	120462937	128787684	23	8039											
PLEKHO1	51177	broad.mit.edu	37	chr1	150129588	150129588	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catctcttcaggtcaccgttGaggaggacagctatcttgcc	8	11	10	12	1	4	1	2	1	2	0	5	3	4	3	2	3	2	2	2	3	1	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:150129588G>C	uc001ett.2	+	5	711	c.433G>C	c.(433-435)GAG>CAG	p.E145Q	PLEKHO1_uc001etr.2_5'UTR|PLEKHO1_uc001ets.2_Intron|PLEKHO1_uc001etu.2_5'UTR	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	145	Interaction with ATM, CKIP, IFP35 and NMI.|Interaction with capping proteins (CPs).					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGTCACCGTTGAGGAGGACAG	0.557													20	88					0	0	0	0	C	150129588	C	C	150129588	3	2	39	1	0	0	0	0	1	0	0	0	12139	1291	45	2	451	2	PLEKHO1	1	150129588	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	29666651	150129588	99121033	24	8040											
CLK2	1196	broad.mit.edu	37	chr1	155236610	155236610	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctttgaggaaatcgaaggTgctaaggcccagaagctcaa	13	8	12	8	1	2	2	1	1	1	1	3	4	2	3	1	3	2	2	1	3	5	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:155236610T>A	uc001fjy.2	-	7	1038	c.748A>T	c.(748-750)ACC>TCC	p.T250S	RAG1AP1_uc010pey.1_Intron|CLK2_uc001fjw.2_Missense_Mutation_p.T249S|CLK2_uc001fjx.2_Missense_Mutation_p.T22S|CLK2_uc009wqm.2_Missense_Mutation_p.T250S	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	250	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AAATCGAAGGTGCTAAGGCCC	0.542								Other_conserved_DNA_damage_response_genes					37	70					0	0	0	0	A	155236610	A	A	155236610	3	1	39	1	0	0	0	0	1	0	0	0	3552	1696	59	5	779	5	CLK2	1	155236610	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	5107022	155236610	94014011	25	8041											
SYT11	23208	broad.mit.edu	37	chr1	155851056	155851056	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaagaaaacccatgtgaaGaagtgcactttgaaccccat	17	7	8	9	0	0	5	0	2	0	3	0	5	0	5	3	0	3	1	3	0	7	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:155851056G>A	uc001fmg.2	+	4	1316	c.1053G>A	c.(1051-1053)AAG>AAA	p.K351K	SYT11_uc010pgq.1_Silent_p.K44K	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	351	C2 2.|Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			CCCATGTGAAGAAGTGCACTT	0.473													95	646					0	0	0	0	A	155851056	A	A	155851056	2	1	39	1	0	0	0	0	0	0	0	1	15533	933	33	2		2	SYT11	1	155851056	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	614446	155851056	93399565	26	8042											
SPTA1	6708	broad.mit.edu	37	chr1	158582745	158582745	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtcctccagtgagacataGcccttcctgtgggagaaatg	10	10	11	10	0	0	2	0	1	0	2	3	4	3	2	4	1	1	0	4	1	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:158582745G>T	uc001fst.1	-	51	7195	c.6996C>A	c.(6994-6996)GGC>GGA	p.G2332G		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2332	EF-hand 2.|2 (Potential).				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GTGAGACATAGCCCTTCCTGT	0.473													33	71					9.78306e-22	1.34154e-21	1	0	T	158582745	T	T	158582745	2	4	39	1	0	0	0	0	0	0	0	1	15182	958	34	4		4	SPTA1	1	158582745	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2731689	158582745	90667876	27	8043											
OR6N1	128372	broad.mit.edu	37	chr1	158735613	158735613	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgcgcaagctgtagatgaagGggttgaggaagggtgtgagc	10	8	19	4	1	0	4	0	3	0	1	0	5	0	5	0	4	3	4	0	4	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:158735613G>T	uc010piq.1	-	1	860	c.860C>A	c.(859-861)CCC>CAC	p.P287H		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GTAGATGAAGGGGTTGAGGAA	0.522													45	239					5.34276e-22	7.3629e-22	1	0	T	158735613	T	T	158735613	3	4	39	1	0	0	0	0	1	0	0	0	11260	1232	43	4	81	4	OR6N1	1	158735613	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	152868	158735613	90515008	28	8044											
MAEL	84944	broad.mit.edu	37	chr1	166974632	166974632	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggattattctagcaacacAaggtattgctagcatttttg	11	15	9	6	0	1	0	0	0	1	0	1	1	1	1	0	2	4	4	0	2	6	8			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:166974632A>T	uc001gdy.1	+	8	914	c.843A>T	c.(841-843)ACA>ACT	p.T281T	MAEL_uc001gdz.1_Silent_p.T250T|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	281					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						CTAGCAACACAAGGTATTGCT	0.373													45	92					0	0	0	0	T	166974632	T	T	166974632	2	4	39	1	0	0	0	0	0	0	0	1	9205	117	5	5		5	MAEL	1	166974632	Silent	SNP	A	TCGA-CN-4727-01A-01D-1434-08	8239019	166974632	82275989	29	8045											
MAEL	84944	broad.mit.edu	37	chr1	166987197	166987197	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggatgcagggcgttaccagGtaaggaactgacttttaaga	12	10	13	6	1	0	2	0	1	0	1	0	4	0	4	1	4	3	3	1	4	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:166987197G>T	uc001gdy.1	+	10	1112	c.1041_splice	c.e10+1	p.Q347_splice	MAEL_uc001gdz.1_Splice_Site_p.Q316_splice|MAEL_uc009wvf.1_Splice_Site	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog						cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						GCGTTACCAGGTAAGGAACTG	0.443													44	100					5.2432e-18	6.99936e-18	1	0	T	166987197	T	T	166987197	5	4	39	1	0	0	0	0	0	0	1	0	9205	1275	44	4	1080	4	MAEL	1	166987197	Splice_Site	SNP	G	TCGA-CN-4727-01A-01D-1434-08	12565	166987197	82263424	30	8046											
C1orf114	57821	broad.mit.edu	37	chr1	169394069	169394069	+	Frame_Shift_Del	DEL	T	-	-																															ctctattatgctggcatcacTtttttcattttcattaatta																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:169394069delT	uc001gga.1	-	2	265	c.97delA	c.(97-99)AGTfs	p.S33fs	C1orf114_uc001gfz.1_Frame_Shift_Del_p.S33fs|C1orf114_uc009wvq.1_Frame_Shift_Del_p.S33fs|C1orf114_uc001ggb.2_Frame_Shift_Del_p.S33fs|C1orf114_uc001ggc.1_Frame_Shift_Del_p.S33fs	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	33											0	all_hematologic(923;0.208)					CTGGCATCACTTTTTTCATTT	0.224													---	---	---								-	169394069	-	-	169394069	7	5	39	1	0	1	0	1	0	0	0	0	1996	1609	56	0	1449	0	C1orf114	1	169394069	Frame_Shift_Del	DEL	T	TCGA-CN-4727-01A-01D-1434-08	2406872	169394069	79856552	31	8047											
DNM3	26052	broad.mit.edu	37	chr1	172357712	172357712	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgatttctctttttcctcaGgtcacctcctccaagcccca	7	14	4	16	0	3	1	2	1	1	0	7	1	6	1	6	1	1	0	6	1	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:172357712G>T	uc001gie.2	+	20	2462	c.2286_splice	c.e20-1	p.R762_splice	DNM3_uc001gif.2_Splice_Site_p.R758_splice|DNM3_uc001gih.1_Splice_Site_p.R118_splice	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a						endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						TTTTTCCTCAGGTCACCTCCT	0.458													20	52					1.56452e-12	1.9261e-12	1	0	T	172357712	T	T	172357712	5	4	39	1	0	0	0	0	0	0	1	0	4695	1014	35	4	2363	4	DNM3	1	172357712	Splice_Site	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2963643	172357712	76892909	32	8048											
PAPPA2	60676	broad.mit.edu	37	chr1	176525640	176525640	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaggttcgaagacccagagCttctccacagcatcacctct	11	8	7	15	1	3	2	1	0	2	2	5	3	3	2	3	1	2	3	3	1	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:176525640C>G	uc001gkz.2	+	2	1346	c.182C>G	c.(181-183)GCT>GGT	p.A61G	PAPPA2_uc001gky.1_Missense_Mutation_p.A61G|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	61					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGACCCAGAGCTTCTCCACAG	0.557													100	216					0	0	0	0	G	176525640	G	G	176525640	3	3	39	1	0	0	0	0	1	0	0	0	11487	797	28	4	184	4	PAPPA2	1	176525640	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4167928	176525640	72724981	33	8049											
CACNA1E	777	broad.mit.edu	37	chr1	181727125	181727125	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcgccaaacctctcaccCgctacatgccgcagaacaga	12	5	7	17	3	2	2	2	0	1	2	3	2	2	2	4	0	5	2	4	0	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:181727125C>T	uc001gow.2	+	31	4537	c.4372C>T	c.(4372-4374)CGC>TGC	p.R1458C	CACNA1E_uc009wxs.2_Missense_Mutation_p.R1346C|CACNA1E_uc001gox.1_Missense_Mutation_p.R684C|CACNA1E_uc009wxt.2_Missense_Mutation_p.R684C	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1458	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						ACCTCTCACCCGCTACATGCC	0.517													30	135					0	0	0	0	T	181727125	T	T	181727125	3	4	39	1	0	0	0	0	1	0	0	0	2554	652	23	1	4494	1	CACNA1E	1	181727125	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	5201485	181727125	67523496	34	8050											
LAMC2	3918	broad.mit.edu	37	chr1	183177137	183177137	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggcattcactgcgagaaGtgcaagaatggcttttaccg	11	10	12	8	2	1	2	1	0	0	2	1	4	1	2	1	2	3	3	1	2	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:183177137G>A	uc001gqa.2	+	2	515	c.201G>A	c.(199-201)AAG>AAA	p.K67K	LAMC2_uc001gpz.3_Silent_p.K67K|LAMC2_uc010poa.1_Translation_Start_Site	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	67	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						ACTGCGAGAAGTGCAAGAATG	0.498													207	366					0	0	0	0	A	183177137	A	A	183177137	2	1	39	1	0	0	0	0	0	0	0	1	8655	1020	36	4		4	LAMC2	1	183177137	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1450012	183177137	66073484	35	8051											
RGS1	5996	broad.mit.edu	37	chr1	192547358	192547358	+	Frame_Shift_Del	DEL	A	-	-																															tcgtttctttttagctggtcAaaatgtctttggaagtttcc																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:192547358delA	uc001gsi.1	+	4	353	c.287delA	c.(286-288)CAAfs	p.Q96fs	RGS1_uc010pou.1_Frame_Shift_Del_p.Q96fs	NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	96	RGS.				immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				TTAGCTGGTCAAAATGTCTTT	0.338													---	---	---								-	192547358	-	-	192547358	7	5	39	1	0	1	0	1	0	0	0	0	13357	130	5	0	301	0	RGS1	1	192547358	Frame_Shift_Del	DEL	A	TCGA-CN-4727-01A-01D-1434-08	9370221	192547358	56703263	36	8052											
CACNA1S	779	broad.mit.edu	37	chr1	201061195	201061195	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgctgctcattggggctGtgtggctttggatgacgtta	4	16	14	7	1	1	1	1	1	0	0	1	2	1	2	0	4	2	5	0	4	1	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:201061195G>A	uc001gvv.2	-	4	673	c.446C>T	c.(445-447)ACA>ATA	p.T149I		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	149	Extracellular (Potential).|I.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CATTGGGGCTGTGTGGCTTTG	0.597													49	74					0	0	0	0	A	201061195	A	A	201061195	3	1	39	1	0	0	0	0	1	0	0	0	2559	1377	48	4	5339	4	CACNA1S	1	201061195	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	8513837	201061195	48189426	37	8053											
PPFIA4	8497	broad.mit.edu	37	chr1	203018892	203018892	+	5'Flank	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtttgtggatggcgtccactCcaggtactgcagcgccagag	7	9	14	11	2	0	1	0	0	0	1	2	2	2	2	3	3	3	3	3	3	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:203018892C>A	uc001gyz.2	+						PPFIA4_uc009xaj.2_Missense_Mutation_p.S654Y|PPFIA4_uc010pqf.1_Missense_Mutation_p.S210Y|PPFIA4_uc001gza.2_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f						cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GGCGTCCACTCCAGGTACTGC	0.627													6	9					0.00116845	0.00122366	1	0	A	203018892	A	A	203018892	1	1	39	0	1	0	0	0	0	0	0	0	12367	870	30	2		2	PPFIA4	1	203018892	5'Flank	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1957697	203018892	46231729	38	8054											
NFASC	23114	broad.mit.edu	37	chr1	204923419	204923419	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgattgacttccgcagtggcGggcggccggaggaatatgag	8	8	17	8	4	0	3	0	3	0	0	1	5	1	5	2	5	0	1	2	5	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:204923419G>T	uc001hbj.2	+	6	647	c.319G>T	c.(319-321)GGG>TGG	p.G107W	NFASC_uc001hbh.2_Missense_Mutation_p.G107W|NFASC_uc010pqz.1_Missense_Mutation_p.G101W|NFASC_uc010pra.1_Missense_Mutation_p.G101W|NFASC_uc001hbi.2_Missense_Mutation_p.G101W|NFASC_uc009xbg.1_Missense_Mutation_p.G174W|NFASC_uc010prb.1_Missense_Mutation_p.G101W|NFASC_uc010prc.1_5'UTR	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	107	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCGCAGTGGCGGGCGGCCGGA	0.582													18	60					1.96895e-08	2.23983e-08	1	0	T	204923419	T	T	204923419	3	4	39	1	0	0	0	0	1	0	0	0	10413	1116	39	3	333	3	NFASC	1	204923419	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1904527	204923419	44327202	39	8055											
PROX1	5629	broad.mit.edu	37	chr1	214170736	214170736	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctcggagatcctggatgcCagggcccaggactctgtcgg	6	7	15	13	3	1	1	0	0	1	1	4	4	2	3	3	5	1	1	3	5	0	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:214170736C>T	uc001hkh.2	+	2	1130	c.858C>T	c.(856-858)GCC>GCT	p.A286A	PROX1_uc001hkg.1_Silent_p.A286A	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	286					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TCCTGGATGCCAGGGCCCAGG	0.502													39	94					0	0	0	0	T	214170736	T	T	214170736	2	4	39	1	0	0	0	0	0	0	0	1	12622	581	21	4		4	PROX1	1	214170736	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	9247317	214170736	35079885	40	8056											
PROX1	5629	broad.mit.edu	37	chr1	214171345	214171345	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccttcccccttcccttgatGgcctatccatttcagagccc	5	12	5	19	0	1	2	1	1	0	1	4	2	4	2	7	1	1	0	7	1	1	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:214171345G>A	uc001hkh.2	+	2	1739	c.1467G>A	c.(1465-1467)ATG>ATA	p.M489I	PROX1_uc001hkg.1_Missense_Mutation_p.M489I	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	489					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TTCCCTTGATGGCCTATCCAT	0.602													64	170					0	0	0	0	A	214171345	A	A	214171345	3	1	39	1	0	0	0	0	1	0	0	0	12622	1348	47	4	1469	4	PROX1	1	214171345	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	609	214171345	35079276	41	8057											
PTPN14	5784	broad.mit.edu	37	chr1	214551325	214551325	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgtccatgggaacccgggTggcatcaactcgattctctt	7	11	10	13	3	2	0	1	0	1	0	6	2	3	1	2	3	2	1	2	3	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:214551325T>A	uc001hkk.1	-	14	2936	c.2665A>T	c.(2665-2667)ACC>TCC	p.T889S	PTPN14_uc010pty.1_Missense_Mutation_p.T790S	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	889					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GGAACCCGGGTGGCATCAACT	0.567													42	94					0	0	0	0	A	214551325	A	A	214551325	3	1	39	1	0	0	0	0	1	0	0	0	12846	1696	59	5	922	5	PTPN14	1	214551325	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	379980	214551325	34699296	42	8058											
HHIPL2	79802	broad.mit.edu	37	chr1	222700357	222700357	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatccacgtggtgcataggCacttgggtaagaggtcgcca	10	8	14	9	2	0	2	0	0	0	2	2	2	1	2	2	4	1	3	2	4	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:222700357C>A	uc001hnh.1	-	7	1817	c.1759G>T	c.(1759-1761)GCC>TCC	p.A587S		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	587					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GGTGCATAGGCACTTGGGTAA	0.433													19	37					3.62473e-10	4.27256e-10	1	0	A	222700357	A	A	222700357	3	1	39	1	0	0	0	0	1	0	0	0	7133	710	25	4	427	4	HHIPL2	1	222700357	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	8149032	222700357	26550264	43	8059											
RHOU	58480	broad.mit.edu	37	chr1	228879196	228879196	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatcctagttggaacgcaGtcggatctcagagaagatgt	12	10	11	8	2	2	2	2	0	1	2	5	5	3	4	1	2	1	2	1	2	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:228879196G>T	uc001htf.2	+	3	1107	c.486G>T	c.(484-486)CAG>CAT	p.Q162H		NM_021205	NP_067028	Q7L0Q8	RHOU_HUMAN	ras homolog gene family, member U	162	GTP.				regulation of small GTPase mediated signal transduction	cell projection|cytosol|focal adhesion|Golgi membrane|podosome	GTP binding|metal ion binding|protein binding				0	Breast(184;0.162)	Prostate(94;0.183)				TTGGAACGCAGTCGGATCTCA	0.527													76	143					2.0493e-37	3.10194e-37	1	0	T	228879196	T	T	228879196	3	4	39	1	0	0	0	0	1	0	0	0	13410	1020	36	4	496	4	RHOU	1	228879196	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	6178839	228879196	20371425	44	8060											
NID1	4811	broad.mit.edu	37	chr1	236154329	236154329	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtaggcaccgcaggtccttGgtgaatcgggggagccactg	7	7	17	10	2	0	1	0	1	0	0	2	2	1	2	3	6	1	3	3	6	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:236154329G>T	uc001hxo.2	-	14	2887	c.2785C>A	c.(2785-2787)CAA>AAA	p.Q929K	NID1_uc009xgd.2_Missense_Mutation_p.Q796K|NID1_uc009xgc.2_Missense_Mutation_p.Q15K	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	929					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCAGGTCCTTGGTGAATCGGG	0.547													22	29					9.86323e-18	1.30101e-17	1	0	T	236154329	T	T	236154329	3	4	39	1	0	0	0	0	1	0	0	0	10468	1357	47	4	986	4	NID1	1	236154329	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	7275133	236154329	13096292	45	8061											
CHRM3	1131	broad.mit.edu	37	chr1	240070839	240070839	+	Frame_Shift_Del	DEL	C	-	-																															gcccctccgatgcagggctgCccccgggaaccgtcactcat																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:240070839delC	uc001hyp.2	+	5	867	c.88delC	c.(88-90)CCCfs	p.P30fs		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	30	Extracellular (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TGCAGGGCTGCCCCCGGGAAC	0.542													---	---	---								-	240070839	-	-	240070839	7	5	39	1	0	1	0	1	0	0	0	0	3393	739	26	0	90	0	CHRM3	1	240070839	Frame_Shift_Del	DEL	C	TCGA-CN-4727-01A-01D-1434-08	3916510	240070839	9179782	46	8062											
RGS7	6000	broad.mit.edu	37	chr1	240964755	240964755	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaaaaaattaaacttacCacattctgtgcaaatttttc	15	14	2	10	0	2	0	1	0	1	0	3	0	2	0	2	0	3	1	2	0	7	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:240964755C>G	uc001hyv.2	-	17	1743	c.1413G>C	c.(1411-1413)GTG>GTC	p.V471V	RGS7_uc010pyh.1_Intron|RGS7_uc010pyj.1_Intron|RGS7_uc001hyu.2_Intron|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Intron|RGS7_uc001hyt.2_Silent_p.V303V	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	471					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TTAAACTTACCACATTCTGTG	0.239													3	40					0	0	0	0	G	240964755	G	G	240964755	2	3	39	1	0	0	0	0	0	0	0	1	13375	608	21	4		4	RGS7	1	240964755	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	893916	240964755	8285866	47	8063											
CNST	163882	broad.mit.edu	37	chr1	246805333	246805333	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggaggagctaccaccaaaGagtcaggtatgtttttaact	14	10	10	7	0	1	1	1	0	0	1	1	3	1	3	2	3	3	3	2	3	5	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:246805333G>A	uc001ibp.2	+	8	1309	c.931G>A	c.(931-933)GAG>AAG	p.E311K	CNST_uc001ibo.3_Missense_Mutation_p.E311K	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	311					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						TACCACCAAAGAGTCAGGTAT	0.418													8	32					0	0	0	0	A	246805333	A	A	246805333	3	1	39	1	0	0	0	0	1	0	0	0	3649	943	33	2	957	2	CNST	1	246805333	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	5840578	246805333	2445288	48	8064											
OR6F1	343169	broad.mit.edu	37	chr1	247875544	247875544	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagaagtggttgatggcacGggggccacagaaggacaggc	12	4	18	7	1	0	3	0	1	0	2	0	5	0	4	1	6	0	2	1	6	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:247875544G>C	uc001idj.1	-	1	514	c.514C>G	c.(514-516)CGT>GGT	p.R172G		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TTGATGGCACGGGGGCCACAG	0.597													49	146					0	0	0	0	C	247875544	C	C	247875544	3	2	39	1	0	0	0	0	1	0	0	0	11255	1116	39	3	416	3	OR6F1	1	247875544	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1070211	247875544	1375077	49	8065											
OR2T4	127074	broad.mit.edu	37	chr1	248525300	248525300	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttcttctacgtgacactaGcaggttcagaatttttcctt	8	17	7	9	1	3	2	1	1	2	1	4	2	4	2	1	1	2	3	1	1	3	8			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:248525300G>T	uc001ieh.1	+	1	418	c.418G>T	c.(418-420)GCA>TCA	p.A140S		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	140	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGTGACACTAGCAGGTTCAGA	0.522													53	277					4.44712e-29	6.39924e-29	1	0	T	248525300	T	T	248525300	3	4	39	1	0	0	0	0	1	0	0	0	11081	971	34	4	420	4	OR2T4	1	248525300	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	649756	248525300	725321	50	8066											
OR2T3	343173	broad.mit.edu	37	chr1	248636987	248636987	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgttcttctacctgaccctGgctggagctgaggttttcct	5	15	10	11	0	2	2	0	2	2	0	3	3	3	3	3	3	2	4	3	3	1	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:248636987G>T	uc001iel.1	+	1	336	c.336G>T	c.(334-336)CTG>CTT	p.L112L		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCTGACCCTGGCTGGAGCTG	0.547													55	96					3.74213e-36	5.61826e-36	1	0	T	248636987	T	T	248636987	2	4	39	1	0	0	0	0	0	0	0	1	11077	1335	47	4		4	OR2T3	1	248636987	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	111687	248636987	613634	51	8067											
OR2T34	127068	broad.mit.edu	37	chr1	248737450	248737450	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatgcagcacaggtacgtGagcatcttatagagggagac	13	7	14	7	1	1	3	0	1	1	2	1	5	1	4	0	3	4	4	0	3	3	3	rs148163660	byFrequency	TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:248737450G>T	uc001iep.1	-	1	609	c.609C>A	c.(607-609)CTC>CTA	p.L203L		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGGTACGTGAGCATCTTAT	0.517													68	324					6.09464e-36	9.12548e-36	1	0	T	248737450	T	T	248737450	2	4	39	1	0	0	0	0	0	0	0	1	11079	1277	45	2		2	OR2T34	1	248737450	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	100463	248737450	513171	52	8068											
OR14I1	401994	broad.mit.edu	37	chr1	248844884	248844884	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcatgatgacaatgagctggGgggagcaggtggagaaggct	11	6	19	5	0	0	4	0	3	0	1	0	6	0	5	0	6	2	4	0	6	2	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr1:248844884G>A	uc001ieu.1	-	1	722	c.722C>T	c.(721-723)CCC>CTC	p.P241L		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	241	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AATGAGCTGGGGGGAGCAGGT	0.468													47	124					0	0	0	0	A	248844884	A	A	248844884	3	1	39	1	0	0	0	0	1	0	0	0	11001	1232	43	4	217	4	OR14I1	1	248844884	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	107434	248844884	405737	53	8069											
PXDN	7837	broad.mit.edu	37	chr2	1677464	1677464	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttgcgtcttcacctctccGgccacgttctttgccatgca	4	14	7	16	3	5	0	1	0	4	0	6	0	5	0	4	1	3	2	4	1	0	4	rs61746899	by1000genomes	TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:1677464G>A	uc002qxa.2	-	9	1033	c.969C>T	c.(967-969)GCC>GCT	p.A323A	PXDN_uc002qxb.1_Silent_p.A323A|PXDN_uc002qxc.1_Silent_p.A140A	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	323	Ig-like C2-type 1.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TCACCTCTCCGGCCACGTTCT	0.562													59	263					0	0	0	0	A	1677464	A	A	1677464	2	1	39	1	0	0	0	0	0	0	0	1	12912	1103	39	1		1	PXDN	2	1677464	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08		1677464	241521909	54	8070											
MYT1L	23040	broad.mit.edu	37	chr2	1906998	1906998	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggccaggttggaacgcggcGtagttgtggggacattgttt	6	12	17	6	3	0	0	0	0	0	0	0	2	0	2	1	6	1	4	1	6	2	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:1906998G>C	uc002qxe.2	-	14	2713	c.1886C>G	c.(1885-1887)ACG>AGG	p.T629R	MYT1L_uc002qxd.2_Missense_Mutation_p.T627R|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	629					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGAACGCGGCGTAGTTGTGGG	0.463													15	43					0	0	0	0	C	1906998	C	C	1906998	3	2	39	1	0	0	0	0	1	0	0	0	10160	1145	40	3	1722	3	MYT1L	2	1906998	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	229534	1906998	241292375	55	8071											
GREB1	9687	broad.mit.edu	37	chr2	11741112	11741112	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatccactggcctgcctcCtgcagtaatgtgagtgccac	8	9	11	13	0	0	2	0	1	0	1	2	3	2	2	5	1	3	2	5	1	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:11741112C>T	uc002rbk.1	+	16	2820	c.2520C>T	c.(2518-2520)TCC>TCT	p.S840S	GREB1_uc002rbo.1_Silent_p.S474S	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	840						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GGCCTGCCTCCTGCAGTAATG	0.532													20	86					0	0	0	0	T	11741112	T	T	11741112	2	4	39	1	0	0	0	0	0	0	0	1	6799	668	24	4		4	GREB1	2	11741112	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	9834114	11741112	231458261	56	8072											
GREB1	9687	broad.mit.edu	37	chr2	11758774	11758774	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcctgccgccagccacccaTtgtcttcttgcccaagctcg	5	9	9	18	2	2	0	0	0	2	0	3	0	2	0	6	1	4	1	6	1	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:11758774T>C	uc002rbk.1	+	22	4073	c.3773T>C	c.(3772-3774)ATT>ACT	p.I1258T	GREB1_uc002rbp.1_Missense_Mutation_p.I256T	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1258						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CAGCCACCCATTGTCTTCTTG	0.667													18	26					0	0	0	0	C	11758774	C	C	11758774	3	2	39	1	0	0	0	0	1	0	0	0	6799	1493	52	5	3963	5	GREB1	2	11758774	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	17662	11758774	231440599	57	8073											
TRIB2	28951	broad.mit.edu	37	chr2	12880596	12880596	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactcgggcaaagcagccgaCgtgtggagcctgggggtgat	8	7	17	9	3	0	1	0	1	0	0	1	3	0	2	2	4	4	2	2	4	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:12880596C>T	uc002rbv.3	+	3	2144	c.708C>T	c.(706-708)GAC>GAT	p.D236D	TRIB2_uc010yjp.1_Silent_p.D100D	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	236	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AAGCAGCCGACGTGTGGAGCC	0.592													11	85					0	0	0	0	T	12880596	T	T	12880596	2	4	39	1	0	0	0	0	0	0	0	1	16550	535	19	1		1	TRIB2	2	12880596	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1121822	12880596	230318777	58	8074											
C2orf44	80304	broad.mit.edu	37	chr2	24255744	24255744	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccaaaagtctgctgaactgTactgagccttagtttaccat	11	12	8	10	0	1	2	0	2	1	0	1	2	1	2	3	0	5	3	3	0	6	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:24255744T>C	uc002rep.2	-	3	2022	c.1891A>G	c.(1891-1893)ACA>GCA	p.T631A	C2orf44_uc010eya.2_Intron	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	631							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCTGAACTGTACTGAGCCTT	0.408													39	177					0	0	0	0	C	24255744	C	C	24255744	3	2	39	1	0	0	0	0	1	0	0	0	2178	1638	57	5	282	5	C2orf44	2	24255744	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	11375148	24255744	218943629	59	8075											
LTBP1	4052	broad.mit.edu	37	chr2	33411996	33411996	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcagtgccctccaaatttCacaggaaaactttgtcagat	12	12	7	10	0	3	1	3	0	0	1	4	2	4	2	2	1	2	0	2	1	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:33411996C>A	uc002ros.2	+	6	1275	c.1275C>A	c.(1273-1275)TTC>TTA	p.F425L	LTBP1_uc002rot.2_Missense_Mutation_p.F99L|LTBP1_uc002rou.2_Missense_Mutation_p.F99L|LTBP1_uc002rov.2_Missense_Mutation_p.F99L|LTBP1_uc010ymz.1_Missense_Mutation_p.F99L|LTBP1_uc010yna.1_Missense_Mutation_p.F99L	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	425	EGF-like 2.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CTCCAAATTTCACAGGAAAAC	0.483													39	68					8.73648e-17	1.13615e-16	1	0	A	33411996	A	A	33411996	3	1	39	1	0	0	0	0	1	0	0	0	9123	825	29	2	1352	2	LTBP1	2	33411996	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	9156252	33411996	209787377	60	8076											
LTBP1	4052	broad.mit.edu	37	chr2	33525538	33525538	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atattgatgaatgtcagcaaGggaatctatgtgtaaacggg	14	11	12	4	1	2	2	1	2	1	0	2	3	2	3	0	2	2	2	0	2	7	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:33525538G>T	uc002ros.2	+	21	3259	c.3259G>T	c.(3259-3261)GGG>TGG	p.G1087W	LTBP1_uc002rot.2_Missense_Mutation_p.G761W|LTBP1_uc002rou.2_Missense_Mutation_p.G760W|LTBP1_uc002rov.2_Missense_Mutation_p.G707W|LTBP1_uc010ymz.1_Missense_Mutation_p.G760W|LTBP1_uc010yna.1_Missense_Mutation_p.G707W|LTBP1_uc010ynb.1_Missense_Mutation_p.G26W	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1086	EGF-like 9; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ATGTCAGCAAGGGAATCTATG	0.488													15	90					4.7546e-09	5.51057e-09	1	0	T	33525538	T	T	33525538	3	4	39	1	0	0	0	0	1	0	0	0	9123	1000	35	4	3393	4	LTBP1	2	33525538	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	113542	33525538	209673835	61	8077											
VRK2	7444	broad.mit.edu	37	chr2	58276056	58276056	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atggaaggcaatcagtgggtActgggcaagaagattggctc	12	8	15	6	0	1	2	1	0	0	2	2	3	1	3	0	5	1	4	0	5	5	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:58276056A>T	uc002rzo.2	+	5	835	c.90A>T	c.(88-90)GTA>GTT	p.V30V	VRK2_uc010fcb.2_Silent_p.V30V|VRK2_uc002rzs.2_Silent_p.V30V|VRK2_uc002rzr.2_Silent_p.V30V|VRK2_uc010fcc.2_5'UTR|VRK2_uc002rzv.2_Silent_p.V30V|VRK2_uc010fcd.2_Silent_p.V7V|VRK2_uc002rzp.2_Silent_p.V30V|VRK2_uc010ypg.1_Silent_p.V30V|VRK2_uc002rzq.2_Silent_p.V30V|VRK2_uc002rzu.2_Silent_p.V30V|VRK2_uc002rzt.2_5'UTR	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	vaccinia related kinase 2 isoform 2	30	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						ATCAGTGGGTACTGGGCAAGA	0.368													20	91					0	0	0	0	T	58276056	T	T	58276056	2	4	39	1	0	0	0	0	0	0	0	1	17288	378	14	5		5	VRK2	2	58276056	Silent	SNP	A	TCGA-CN-4727-01A-01D-1434-08	24750518	58276056	184923317	62	8078											
PEX13	5194	broad.mit.edu	37	chr2	61275876	61275876	+	Frame_Shift_Del	DEL	G	-	-																															cagttgcacctgattccattGggaaagatggagaaaagcaa																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:61275876delG	uc002sau.3	+	4	1266	c.1183delG	c.(1183-1185)GGGfs	p.G395fs		NM_002618	NP_002609	Q92968	PEX13_HUMAN	peroxisomal biogenesis factor 13	395	Cytoplasmic (Potential).				cerebral cortex cell migration|fatty acid alpha-oxidation|locomotory behavior|microtubule-based peroxisome localization|neuron migration|protein import into peroxisome matrix, docking|suckling behavior	integral to peroxisomal membrane|membrane fraction	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(5;2.05e-06)|Lung(5;3.13e-05)|Epithelial(17;0.114)			TGATTCCATTGGGAAAGATGG	0.358													---	---	---								-	61275876	-	-	61275876	7	5	39	1	0	1	0	1	0	0	0	0	11796	1348	47	0	1197	0	PEX13	2	61275876	Frame_Shift_Del	DEL	G	TCGA-CN-4727-01A-01D-1434-08	2999820	61275876	181923497	63	8079											
DYSF	8291	broad.mit.edu	37	chr2	71742778	71742778	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccaggtgatcgaggggcGccagctgccgggggtgaaca	7	5	19	10	3	0	2	0	2	0	0	2	3	1	2	3	6	3	1	3	6	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:71742778G>A	uc002sie.2	+	7	1065	c.689G>A	c.(688-690)CGC>CAC	p.R230H	DYSF_uc010feg.2_Missense_Mutation_p.R261H|DYSF_uc010feh.2_Missense_Mutation_p.R230H|DYSF_uc002sig.3_Missense_Mutation_p.R230H|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R230H|DYSF_uc010fef.2_Missense_Mutation_p.R261H|DYSF_uc010fei.2_Missense_Mutation_p.R261H|DYSF_uc010fek.2_Missense_Mutation_p.R262H|DYSF_uc010fej.2_Missense_Mutation_p.R231H|DYSF_uc010fel.2_Missense_Mutation_p.R231H|DYSF_uc010feo.2_Missense_Mutation_p.R262H|DYSF_uc010fem.2_Missense_Mutation_p.R231H|DYSF_uc010fen.2_Missense_Mutation_p.R262H|DYSF_uc002sif.2_Missense_Mutation_p.R231H	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	230	Cytoplasmic (Potential).|C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						ATCGAGGGGCGCCAGCTGCCG	0.592													56	160					0	0	0	0	A	71742778	A	A	71742778	3	1	39	1	0	0	0	0	1	0	0	0	4881	1087	38	1	907	1	DYSF	2	71742778	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	10466902	71742778	171456595	64	8080											
C2orf65	130951	broad.mit.edu	37	chr2	74789507	74789507	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaattctctggctgtgtcctGggcccggtggttcccccttg	2	13	13	13	1	1	0	0	0	1	0	4	1	3	0	4	4	0	2	4	4	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:74789507G>C	uc002smy.2	-	8	1235	c.1118C>G	c.(1117-1119)CCA>CGA	p.P373R	C2orf65_uc010ysa.1_Missense_Mutation_p.P373R|C2orf65_uc010ffp.2_Intron|C2orf65_uc002smx.2_Missense_Mutation_p.P129R	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	373					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						GCTGTGTCCTGGGCCCGGTGG	0.527													32	88					0	0	0	0	C	74789507	C	C	74789507	3	2	39	1	0	0	0	0	1	0	0	0	2194	1348	47	4	490	4	C2orf65	2	74789507	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	3046729	74789507	168409866	65	8081											
LRRTM4	80059	broad.mit.edu	37	chr2	76975838	76975838	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgttagtttgcaattctctCtaggtagatggccggtgctg	6	14	13	8	2	2	1	0	0	2	1	3	1	2	1	1	3	2	5	1	3	4	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:76975838C>G	uc002snr.2	-	4	2171	c.1756G>C	c.(1756-1758)GAG>CAG	p.E586Q	LRRTM4_uc002snq.2_Missense_Mutation_p.E586Q	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	586	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GCAATTCTCTCTAGGTAGATG	0.597													45	124					0	0	0	0	G	76975838	G	G	76975838	3	3	39	1	0	0	0	0	1	0	0	0	9092	922	32	2	20	2	LRRTM4	2	76975838	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2186331	76975838	166223535	66	8082											
REG1A	5967	broad.mit.edu	37	chr2	79349177	79349177	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcacccaggccgagggtgccTttgtggcctcactgattaag	7	10	12	12	1	2	1	2	1	0	0	2	2	2	1	4	3	1	0	4	3	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:79349177T>A	uc002snz.2	+	4	350	c.247T>A	c.(247-249)TTT>ATT	p.F83I	REG1A_uc010ffx.1_3'UTR|REG1A_uc010ysd.1_Missense_Mutation_p.F83I	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	83	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CGAGGGTGCCTTTGTGGCCTC	0.522													29	111					0	0	0	0	A	79349177	A	A	79349177	3	1	39	1	0	0	0	0	1	0	0	0	13275	1609	56	5	257	5	REG1A	2	79349177	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	2373339	79349177	163850196	67	8083											
AFF3	3899	broad.mit.edu	37	chr2	100625372	100625372	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcgttctttcctccgtaatgCatttctatctggttcataga	7	18	6	10	2	4	1	1	0	3	1	7	1	6	1	2	1	1	4	2	1	3	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:100625372C>T	uc002tag.2	-	4	312	c.76G>A	c.(76-78)GCA>ACA	p.A26T	AFF3_uc002taf.2_Missense_Mutation_p.A51T|AFF3_uc010fiq.1_Missense_Mutation_p.A26T|AFF3_uc010yvr.1_Missense_Mutation_p.A180T|AFF3_uc002tah.1_Missense_Mutation_p.A51T|AFF3_uc010fir.1_Missense_Mutation_p.A103T|AFF3_uc002tai.2_5'Flank	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	26					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CTCCGTAATGCATTTCTATCT	0.398													8	29					0	0	0	0	T	100625372	T	T	100625372	3	4	39	1	0	0	0	0	1	0	0	0	358	710	25	4	3688	4	AFF3	2	100625372	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	21276195	100625372	142574001	68	8084											
DPP10	57628	broad.mit.edu	37	chr2	115200370	115200370	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaacatgaaccaaactgcCagcgtgtcccatcacatcaa	15	7	6	13	1	2	2	2	2	0	0	3	2	3	2	3	0	5	0	3	0	4	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:115200370C>A	uc002tla.1	+	1	472	c.15C>A	c.(13-15)GCC>GCA	p.A5A		NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	5	Mediates effects on KCND2.|Cytoplasmic (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ACCAAACTGCCAGCGTGTCCC	0.468													15	47					3.32936e-07	3.69632e-07	1	0	A	115200370	A	A	115200370	2	1	39	1	0	0	0	0	0	0	0	1	4749	581	21	4		4	DPP10	2	115200370	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	14574998	115200370	127999003	69	8085											
LIMS2	55679	broad.mit.edu	37	chr2	128414981	128414981	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcagtagtgtcctcacctcaTagaagagcccctcggggaag	10	8	11	12	1	3	2	3	0	0	2	5	3	4	3	4	2	1	1	4	2	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:128414981T>G	uc002tpa.2	-	2	333	c.167A>C	c.(166-168)TAT>TCT	p.Y56S	LIMS2_uc002tox.2_Missense_Mutation_p.Y80S|LIMS2_uc010fmb.2_5'UTR|LIMS2_uc002toy.2_Missense_Mutation_p.Y51S|LIMS2_uc010yzm.1_Missense_Mutation_p.Y78S|LIMS2_uc002toz.2_Missense_Mutation_p.Y51S|LIMS2_uc002tpb.2_Missense_Mutation_p.Y51S	NM_001161403	NP_001154875	Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	56	LIM zinc-binding 1.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		CCTCACCTCATAGAAGAGCCC	0.627													55	105					0	0	0	0	G	128414981	G	G	128414981	3	3	39	1	0	0	0	0	1	0	0	0	8845	1406	49	5	894	5	LIMS2	2	128414981	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	13214611	128414981	114784392	70	8086											
CXCR4	7852	broad.mit.edu	37	chr2	136872794	136872794	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgtggtcttgagggccttgCgcttctggtggcccttggag	2	13	16	10	1	2	1	0	1	2	0	2	2	2	2	2	5	1	1	2	5	0	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:136872794C>G	uc002tuz.2	-	2	799	c.704G>C	c.(703-705)CGC>CCC	p.R235P	CXCR4_uc002tuy.2_Missense_Mutation_p.R239P|CXCR4_uc010fnk.2_Missense_Mutation_p.R220P	NM_003467	NP_003458	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4 isoform b	235	Cytoplasmic.				activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)	GAGGGCCTTGCGCTTCTGGTG	0.522													100	173					0	0	0	0	G	136872794	G	G	136872794	3	3	39	1	0	0	0	0	1	0	0	0	4110	768	27	3	358	3	CXCR4	2	136872794	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	8457813	136872794	106326579	71	8087											
THSD7B	80731	broad.mit.edu	37	chr2	138376011	138376011	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaccctgtggtcaaggcgtCaggacccgcctgctaagctg	7	7	13	14	2	2	0	2	0	0	0	2	1	2	1	3	3	2	3	3	3	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:138376011C>T	uc002tva.1	+	18	3528	c.3528C>T	c.(3526-3528)GTC>GTT	p.V1176V	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GTCAAGGCGTCAGGACCCGCC	0.507													6	42					0	0	0	0	T	138376011	T	T	138376011	2	4	39	1	0	0	0	0	0	0	0	1	15946	813	29	2		2	THSD7B	2	138376011	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1503217	138376011	104823362	72	8088											
NR4A2	4929	broad.mit.edu	37	chr2	157182511	157182511	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttccttgagcccgtgtctCtctgcagaaaacataatcag	10	11	9	11	1	3	2	1	1	2	1	5	2	4	2	2	1	3	2	2	1	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:157182511C>A	uc002tyz.3	-	8	1964	c.1542G>T	c.(1540-1542)GAG>GAT	p.E514D	NR4A2_uc002tyx.3_Missense_Mutation_p.E451D|NR4A2_uc010zcf.1_Missense_Mutation_p.E514D	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	514					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GCCCGTGTCTCTCTGCAGAAA	0.423													9	62					0.000274275	0.000288875	1	0	A	157182511	A	A	157182511	3	1	39	1	0	0	0	0	1	0	0	0	10687	927	32	2	258	2	NR4A2	2	157182511	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	18806500	157182511	86016862	73	8089											
LRP2	4036	broad.mit.edu	37	chr2	170063612	170063612	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtctctgcccatagtcagcCcagaagaggtatctgttctt	8	12	10	11	0	4	2	1	0	3	2	5	2	4	2	2	2	2	2	2	2	3	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:170063612C>A	uc002ues.2	-	39	6831	c.6618G>T	c.(6616-6618)TGG>TGT	p.W2206C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2206	LDL-receptor class B 22.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CATAGTCAGCCCAGAAGAGGT	0.483													114	249					5.16181e-52	8.0102e-52	1	0	A	170063612	A	A	170063612	3	1	39	1	0	0	0	0	1	0	0	0	9006	624	22	4	7513	4	LRP2	2	170063612	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	12881101	170063612	73135761	74	8090											
GAD1	2571	broad.mit.edu	37	chr2	171702239	171702240	+	Frame_Shift_Ins	INS	-	G	G																															actattccataaagaaagctINSggggctgcacttggctttgg																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:171702239_171702240insG	uc002ugi.2	+	9	1313_1314	c.891_892insG	c.(889-894)GCTGGGfs	p.A297fs		NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	297_298					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TAAAGAAAGCTGGGGCTGCACT	0.426													---	---	---								G	171702240	G	G	171702239	7	5	39	1	0	1	1	0	0	0	0	0	6213	1567	55	0	962	0	GAD1	2	171702239	Frame_Shift_Ins	INS	-	TCGA-CN-4727-01A-01D-1434-08	1638627	171702239	71497134	75	8091											
ITGA6	3655	broad.mit.edu	37	chr2	173333907	173333907	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaatacgaagcaggaatccCgagacatctttgggcggtgt	11	10	12	8	3	1	1	0	0	1	1	2	4	2	2	1	3	2	1	1	3	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:173333907C>G	uc002uhp.1	+	4	645	c.442C>G	c.(442-444)CGA>GGA	p.R148G	ITGA6_uc010fqk.1_Missense_Mutation_p.R34G|ITGA6_uc010zdy.1_Missense_Mutation_p.R34G|ITGA6_uc002uho.1_Missense_Mutation_p.R148G|ITGA6_uc010fql.2_5'Flank	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	148	Extracellular (Potential).|FG-GAP 2.				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			GCAGGAATCCCGAGACATCTT	0.458													56	374					0	0	0	0	G	173333907	G	G	173333907	3	3	39	1	0	0	0	0	1	0	0	0	7919	644	23	3	456	3	ITGA6	2	173333907	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1631668	173333907	69865466	76	8092											
TTN	7273	broad.mit.edu	37	chr2	179529453	179529453	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagggacaatttcttggaGagcttcaggcactttaagaa	12	12	10	7	0	3	2	2	0	1	2	3	4	3	3	0	3	1	2	0	3	3	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:179529453G>T	uc010zfk.1	-	12	1116	c.568C>A	c.(568-570)CTC>ATC	p.L190I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTCTTGGAGAGCTTCAGGC	0.383													41	26					3.54909e-21	4.83095e-21	1	0	T	179529453	T	T	179529453	3	4	39	1	0	0	0	0	1	0	0	0	16803	957	33	2		2	TTN	2	179529453	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	6195546	179529453	63669920	77	8093											
TTN	7273	broad.mit.edu	37	chr2	179593122	179593122	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgatggaggaatattttGatctgtccaatgcaaacagc	14	11	10	6	0	1	2	0	2	1	0	2	5	2	4	1	2	3	1	1	2	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:179593122G>T	uc010zfg.1	-	64	15921	c.15697C>A	c.(15697-15699)CAA>AAA	p.Q5233K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.Q1894K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6160							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E5233K(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAATATTTTGATCTGTCCAA	0.373													13	14					9.05144e-12	1.09967e-11	1	0	T	179593122	T	T	179593122	3	4	39	1	0	0	0	0	1	0	0	0	16803	1299	45	2	85284	2	TTN	2	179593122	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	63669	179593122	63606251	78	8094											
ZNF804A	91752	broad.mit.edu	37	chr2	185803442	185803442	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acactgttttgcagcagcacGctgcagctgctgcagctgca	8	9	11	13	1	0	0	0	0	0	0	0	0	0	0	0	0	9	11	0	0	0	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:185803442G>T	uc002uph.2	+	4	3913	c.3319G>T	c.(3319-3321)GCT>TCT	p.A1107S		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1107						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						gcagcagcacgctgcagctgc	0.373													22	22					1.26612e-14	1.6051e-14	1	0	T	185803442	T	T	185803442	3	4	39	1	0	0	0	0	1	0	0	0	18237	1087	38	3	3333	3	ZNF804A	2	185803442	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	6210320	185803442	57395931	79	8095											
ZNF804A	91752	broad.mit.edu	37	chr2	185803545	185803545	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatcccagctctcaccagaaCctcattacctcagctctcag	11	9	4	17	0	4	1	4	0	2	1	7	1	5	1	4	0	4	2	4	0	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:185803545C>A	uc002uph.2	+	4	4016	c.3422C>A	c.(3421-3423)ACC>AAC	p.T1141N		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1141						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CTCACCAGAACCTCATTACCT	0.408													79	75					9.42754e-34	1.39276e-33	1	0	A	185803545	A	A	185803545	3	1	39	1	0	0	0	0	1	0	0	0	18237	507	18	4	3436	4	ZNF804A	2	185803545	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	103	185803545	57395828	80	8096											
ERBB4	2066	broad.mit.edu	37	chr2	212488770	212488770	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagttaatggttccaccaaCtgcaaagcggaaagaagaag	16	6	12	7	1	0	2	0	0	0	2	1	4	1	4	2	3	3	3	2	3	6	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:212488770C>A	uc002veg.1	-	18	2178	c.2080_splice	c.e18-1	p.L694_splice	ERBB4_uc002veh.1_Splice_Site_p.L694_splice|ERBB4_uc010zji.1_Splice_Site_p.L684_splice|ERBB4_uc010zjj.1_Splice_Site_p.L684_splice|ERBB4_uc010fut.1_Splice_Site_p.L694_splice	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene						cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTTCCACCAACTGCAAAGCGG	0.368										TSP Lung(8;0.080)			47	39					1.83081e-24	2.59403e-24	1	0	A	212488770	A	A	212488770	5	1	39	1	0	0	0	0	0	0	1	0	5233	579	20	4	1891	4	ERBB4	2	212488770	Splice_Site	SNP	C	TCGA-CN-4727-01A-01D-1434-08	26685225	212488770	30710603	81	8097											
ABCB6	10058	broad.mit.edu	37	chr2	220083227	220083227	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agacagcgaatcagcaccagCgggccgctcccggcgtctgc	8	4	13	16	5	2	1	1	0	1	1	3	2	3	1	3	2	4	2	3	2	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr2:220083227C>A	uc002vkc.1	-	1	446	c.169G>T	c.(169-171)GCT>TCT	p.A57S	ABCB6_uc010fwe.1_Missense_Mutation_p.A57S|ABCB6_uc010zku.1_RNA|ATG9A_uc002vkd.1_RNA	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	57					cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAGCACCAGCGGGCCGCTCC	0.687													8	11					3.09899e-07	3.44747e-07	1	0	A	220083227	A	A	220083227	3	1	39	1	0	0	0	0	1	0	0	0	45	768	27	3	2435	3	ABCB6	2	220083227	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	7594457	220083227	23116146	82	8098											
CNTN6	27255	broad.mit.edu	37	chr3	1337387	1337387	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacttgtacattgccaaagTggaaccatcagatgtgggca	14	9	10	8	0	1	1	1	0	0	1	1	2	1	2	2	2	4	2	2	2	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:1337387T>A	uc003boz.2	+	6	824	c.557T>A	c.(556-558)GTG>GAG	p.V186E	CNTN6_uc010hbo.2_Missense_Mutation_p.V181E|CNTN6_uc011asj.1_Missense_Mutation_p.V114E|CNTN6_uc003bpa.2_Missense_Mutation_p.V186E	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	186	Ig-like C2-type 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ATTGCCAAAGTGGAACCATCA	0.443													21	70					0	0	0	0	A	1337387	A	A	1337387	3	1	39	1	0	0	0	0	1	0	0	0	3660	1696	59	5	575	5	CNTN6	3	1337387	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08		1337387	196685043	83	8099											
TRIM71	131405	broad.mit.edu	37	chr3	32933213	32933213	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gctcaaggcagcggctttggGcagatggaccgcccttccgg	6	7	15	13	3	1	1	1	0	0	1	2	2	2	2	3	5	1	4	3	5	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:32933213G>A	uc003cff.2	+	4	2580	c.2517G>A	c.(2515-2517)GGG>GGA	p.G839G		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	839	NHL 6.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						GCGGCTTTGGGCAGATGGACC	0.547													46	220					0	0	0	0	A	32933213	A	A	32933213	2	1	39	1	0	0	0	0	0	0	0	1	16611	1190	42	4		4	TRIM71	3	32933213	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	31595826	32933213	165089217	84	8100											
SLC6A20	54716	broad.mit.edu	37	chr3	45800531	45800531	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacaaaagtccccagggccGccagggggatgcacatggtg	11	4	15	11	1	0	0	0	0	0	0	1	2	1	1	4	4	2	1	4	4	3	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:45800531G>T	uc011bai.1	-	11	1842	c.1718C>A	c.(1717-1719)GCG>GAG	p.A573E	SLC6A20_uc003cow.2_Missense_Mutation_p.A223E|SLC6A20_uc011baj.1_Missense_Mutation_p.A536E	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	573	Helical; Name=12; (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CCCCAGGGCCGCCAGGGGGAT	0.612													42	39					2.54651e-27	3.65483e-27	1	0	T	45800531	T	T	45800531	3	4	39	1	0	0	0	0	1	0	0	0	14748	1087	38	3	64	3	SLC6A20	3	45800531	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	12867318	45800531	152221899	85	8101											
PTH1R	5745	broad.mit.edu	37	chr3	46944837	46944837	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgaaaggcacgcagcgggagCagcagctatagctacggccc	11	3	14	13	4	0	0	0	0	0	0	0	2	0	1	1	3	6	6	1	3	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:46944837C>A	uc003cqm.2	+	16	1676	c.1473C>A	c.(1471-1473)AGC>AGA	p.S491R	PTH1R_uc003cqn.2_Missense_Mutation_p.S491R	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	491	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						GCAGCGGGAGCAGCAGCTATA	0.622									Ollier_disease_/_Maffuci_syndrome				24	23					7.4402e-23	1.03047e-22	1	0	A	46944837	A	A	46944837	3	1	39	1	0	0	0	0	1	0	0	0	12821	709	25	4	1527	4	PTH1R	3	46944837	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1144306	46944837	151077593	86	8102											
CELSR3	1951	broad.mit.edu	37	chr3	48696506	48696506	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcgcccaataatgcccgacgGgaaggtgtctgaacggttgg	9	7	15	10	4	1	1	0	1	1	0	1	3	1	2	2	4	2	1	2	4	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:48696506G>T	uc003cul.2	-	1	3843	c.3562C>A	c.(3562-3564)CCG>ACG	p.P1188T	CELSR3_uc003cuf.1_Missense_Mutation_p.P1258T	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1188	Extracellular (Potential).|Cadherin 9.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATGCCCGACGGGAAGGTGTCT	0.537													61	52					2.91325e-39	4.44612e-39	1	0	T	48696506	T	T	48696506	3	4	39	1	0	0	0	0	1	0	0	0	3238	1232	43	4	6516	4	CELSR3	3	48696506	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1751669	48696506	149325924	87	8103											
WDR6	11180	broad.mit.edu	37	chr3	49050668	49050668	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaccctgccctctctgcaCgggaagcagggtgtgacctc	6	9	11	15	1	2	1	0	1	2	0	4	2	2	2	3	2	4	2	3	2	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:49050668C>G	uc003cvj.2	+	2	1929	c.1791C>G	c.(1789-1791)CAC>CAG	p.H597Q	WDR6_uc011bbx.1_Intron|WDR6_uc011bby.1_Intron|WDR6_uc010hkn.2_Missense_Mutation_p.H541Q|WDR6_uc011bbz.1_Missense_Mutation_p.H516Q	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	567	WD 9.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CCTCTCTGCACGGGAAGCAGG	0.597													4	55					0	0	0	0	G	49050668	G	G	49050668	3	3	39	1	0	0	0	0	1	0	0	0	17378	535	19	3	1797	3	WDR6	3	49050668	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	354162	49050668	148971762	88	8104											
NISCH	11188	broad.mit.edu	37	chr3	52526337	52526337	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcaccctggaccactttGgggaggtgccaggtggcccg	5	8	16	12	1	1	0	1	0	0	0	1	2	1	2	4	6	1	0	4	6	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:52526337G>A	uc011beg.1	+	22	4426	c.4354G>A	c.(4354-4356)GGG>AGG	p.G1452R	NISCH_uc003ded.3_Missense_Mutation_p.G1452R|NISCH_uc003dee.3_Missense_Mutation_p.G941R|NISCH_uc003deg.1_Intron|NISCH_uc003deh.3_Missense_Mutation_p.G201R	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1452					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		GGACCACTTTGGGGAGGTGCC	0.617													166	160					0	0	0	0	A	52526337	A	A	52526337	3	1	39	1	0	0	0	0	1	0	0	0	10486	1348	47	4	4436	4	NISCH	3	52526337	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	3475669	52526337	145496093	89	8105											
CNTN3	5067	broad.mit.edu	37	chr3	74334568	74334568	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttcaggccccgtagtctGgctgatgtctcatttcctgc	4	14	9	14	1	4	1	2	1	3	0	6	1	5	1	3	2	1	2	3	2	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:74334568G>C	uc003dpm.1	-	19	2672	c.2592C>G	c.(2590-2592)GCC>GCG	p.A864A		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	864	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CCCGTAGTCTGGCTGATGTCT	0.547													44	163					0	0	0	0	C	74334568	C	C	74334568	2	2	39	1	0	0	0	0	0	0	0	1	3657	1335	47	4		4	CNTN3	3	74334568	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	21808231	74334568	123687862	90	8106											
ROBO2	6092	broad.mit.edu	37	chr3	77629206	77629206	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtattcaataccgggtaGaggttgcagctagtaccagt	11	10	12	8	1	1	1	1	0	0	1	1	1	1	1	2	3	4	6	2	3	6	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:77629206G>A	uc003dpy.3	+	16	3080	c.2437G>A	c.(2437-2439)GAG>AAG	p.E813K	ROBO2_uc003dpz.2_Missense_Mutation_p.E817K|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.E817K	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	813	Fibronectin type-III 3.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ATACCGGGTAGAGGTTGCAGC	0.438													47	58					0	0	0	0	A	77629206	A	A	77629206	3	1	39	1	0	0	0	0	1	0	0	0	13579	943	33	2	2501	2	ROBO2	3	77629206	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	3294638	77629206	120393224	91	8107											
CADM2	253559	broad.mit.edu	37	chr3	86114784	86114784	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctttggctggccagaatggcCctgaccatgctctcatagga	8	10	11	12	0	1	2	1	1	1	1	2	3	1	3	3	4	1	2	3	4	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:86114784C>G	uc003dqj.2	+	9	1719	c.1093C>G	c.(1093-1095)CCT>GCT	p.P365A	CADM2_uc003dqk.2_Missense_Mutation_p.P334A|CADM2_uc003dql.2_Missense_Mutation_p.P367A	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	365	Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CCAGAATGGCCCTGACCATGC	0.403													37	37					0	0	0	0	G	86114784	G	G	86114784	3	3	39	1	0	0	0	0	1	0	0	0	2579	623	22	4	1198	4	CADM2	3	86114784	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	8485578	86114784	111907646	92	8108											
PROS1	5627	broad.mit.edu	37	chr3	93615516	93615516	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actttgtgtcaaggttcaagGgaaggcacactgaaacaacc	14	8	10	9	0	2	1	2	1	0	0	2	2	2	2	1	3	2	2	1	3	5	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:93615516G>A	uc003drb.3	-	9	1210	c.869C>T	c.(868-870)CCC>CTC	p.P290L	PROS1_uc010hoo.2_Missense_Mutation_p.P159L|PROS1_uc003dqz.3_Missense_Mutation_p.P159L	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	290					leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	AAGGTTCAAGGGAAGGCACAC	0.368													60	176					0	0	0	0	A	93615516	A	A	93615516	3	1	39	1	0	0	0	0	1	0	0	0	12620	1232	43	4	1189	4	PROS1	3	93615516	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	7500732	93615516	104406914	93	8109											
COL8A1	1295	broad.mit.edu	37	chr3	99514875	99514875	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtgctgctgctcaggccCggagaccgggtgttcctcca	5	8	14	14	2	1	1	1	0	0	1	3	2	3	1	4	3	3	5	4	3	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:99514875C>A	uc003dtg.1	+	5	2375	c.2130C>A	c.(2128-2130)CCC>CCA	p.P710P	COL8A1_uc003dth.1_Silent_p.P710P|COL8A1_uc003dti.1_Silent_p.P711P	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	710	C1q.|Nonhelical region (NC1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						TGCTCAGGCCCGGAGACCGGG	0.542													27	76					1.17739e-12	1.45273e-12	1	0	A	99514875	A	A	99514875	2	1	39	1	0	0	0	0	0	0	0	1	3720	639	23	3		3	COL8A1	3	99514875	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	5899359	99514875	98507555	94	8110											
NFKBIZ	64332	broad.mit.edu	37	chr3	101572505	101572505	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcttcagcatgatgcccAgcagcgcctgtgaggccatg	9	7	12	13	1	1	2	1	2	0	0	1	2	1	2	3	1	5	3	3	1	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:101572505A>T	uc003dvp.2	+	5	1250	c.1135A>T	c.(1135-1137)AGC>TGC	p.S379C	NFKBIZ_uc003dvo.2_Missense_Mutation_p.S279C|NFKBIZ_uc010hpo.2_Missense_Mutation_p.S279C|NFKBIZ_uc003dvq.2_Missense_Mutation_p.S257C	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	379	Required for transcriptional activity (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						CATGATGCCCAGCAGCGCCTG	0.493													64	139					0	0	0	0	T	101572505	T	T	101572505	3	4	39	1	0	0	0	0	1	0	0	0	10437	188	7	5	1153	5	NFKBIZ	3	101572505	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	2057630	101572505	96449925	95	8111											
SIDT1	54847	broad.mit.edu	37	chr3	113323815	113323815	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatccagctggtcattaccTatcagacagtaagtgctgcc	10	11	9	11	0	2	2	2	1	0	1	3	2	3	2	3	1	4	3	3	1	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:113323815T>A	uc003eak.2	+	14	2047	c.1396T>A	c.(1396-1398)TAT>AAT	p.Y466N	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.Y466N|SIDT1_uc011big.1_Missense_Mutation_p.Y219N|SIDT1_uc011bih.1_RNA|SIDT1_uc011bii.1_5'UTR	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	466	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						GGTCATTACCTATCAGACAGT	0.498													35	103					0	0	0	0	A	113323815	A	A	113323815	3	1	39	1	0	0	0	0	1	0	0	0	14367	1522	53	5	1450	5	SIDT1	3	113323815	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	11751310	113323815	84698615	96	8112											
DRD3	1814	broad.mit.edu	37	chr3	113858352	113858352	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccagggtacttacttgctGggggaagccaggcctgacac	8	8	13	12	0	0	1	0	1	0	0	1	2	1	2	3	4	4	2	3	4	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:113858352G>T	uc003ebd.2	-	6	1141	c.718C>A	c.(718-720)CAG>AAG	p.Q240K	DRD3_uc010hqn.1_Missense_Mutation_p.Q240K|DRD3_uc003ebb.1_Missense_Mutation_p.Q240K|DRD3_uc003ebc.1_Missense_Mutation_p.Q240K	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	240	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	CTTACTTGCTGGGGGAAGCCA	0.512													75	212					1.43161e-34	2.13202e-34	1	0	T	113858352	T	T	113858352	3	4	39	1	0	0	0	0	1	0	0	0	4780	1357	47	4	496	4	DRD3	3	113858352	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	534537	113858352	84164078	97	8113											
FSTL1	11167	broad.mit.edu	37	chr3	120121736	120121736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacctcggtctcagctccatCtgcatacgtttcatcctcca	7	12	5	17	2	3	0	2	0	2	0	8	0	6	0	4	1	3	3	4	1	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:120121736C>T	uc003eds.2	-	9	899	c.724G>A	c.(724-726)GAT>AAT	p.D242N	FSTL1_uc011bjh.1_Missense_Mutation_p.D207N	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	follistatin-like 1 precursor	242	VWFC.				BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.189)		TCAGCTCCATCTGCATACGTT	0.537													52	130					0	0	0	0	T	120121736	T	T	120121736	3	4	39	1	0	0	0	0	1	0	0	0	6111	913	32	2	214	2	FSTL1	3	120121736	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	6263384	120121736	77900694	98	8114											
POLQ	10721	broad.mit.edu	37	chr3	121195496	121195496	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatatgtttctgactttcaCattctgcagtactaaagcca	11	16	5	9	0	3	1	1	1	2	0	3	1	3	1	1	0	3	3	1	0	5	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:121195496C>A	uc003eee.3	-	20	6425	c.6296G>T	c.(6295-6297)TGT>TTT	p.C2099F	POLQ_uc003eed.2_Missense_Mutation_p.C1271F	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2099					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CTGACTTTCACATTCTGCAGT	0.428								DNA_polymerases_(catalytic_subunits)					32	81					1.74807e-11	2.10528e-11	1	0	A	121195496	A	A	121195496	3	1	39	1	0	0	0	0	1	0	0	0	12263	478	17	4	1520	4	POLQ	3	121195496	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1073760	121195496	76826934	99	8115											
SEC61A1	29927	broad.mit.edu	37	chr3	127783719	127783719	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtctcctcctctgccaacaGgaatggaatttgaaggtgct	9	12	10	10	0	2	1	0	1	2	0	4	3	3	3	3	3	3	1	3	3	4	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:127783719G>A	uc003ekb.2	+	8	801	c.617_splice	c.e8-1	p.G206_splice	RUVBL1_uc003eke.2_3'UTR|RUVBL1_uc003ekf.2_3'UTR|SEC61A1_uc003ekc.2_Splice_Site_p.G153_splice|SEC61A1_uc003ekd.2_Splice_Site_p.G86_splice|SEC61A1_uc003ekg.2_5'Flank	NM_013336	NP_037468	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit						protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			ovary(1)	1						TCTGCCAACAGGAATGGAATT	0.468													36	67					0	0	0	0	A	127783719	A	A	127783719	5	1	39	1	0	0	0	0	0	0	1	0	14065	1014	35	4	646	4	SEC61A1	3	127783719	Splice_Site	SNP	G	TCGA-CN-4727-01A-01D-1434-08	6588223	127783719	70238711	100	8116											
COL6A6	131873	broad.mit.edu	37	chr3	130285860	130285860	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcaaaaagcaaagaagcagCgaggaaacaaagttccatgc	19	4	10	8	1	0	1	0	0	0	1	1	3	1	2	1	1	6	4	1	1	6	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:130285860C>A	uc010htl.2	+	4	1628	c.1597C>A	c.(1597-1599)CGA>AGA	p.R533R		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	533	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AAAGAAGCAGCGAGGAAACAA	0.483													38	112					6.53348e-20	8.82816e-20	1	0	A	130285860	A	A	130285860	2	1	39	1	0	0	0	0	0	0	0	1	3718	760	27	3		3	COL6A6	3	130285860	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2502141	130285860	67736570	101	8117											
MED12L	116931	broad.mit.edu	37	chr3	150911327	150911327	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaatgccaacacttcgttGggcagaagaatgtcagttaa	14	9	11	7	1	1	3	1	0	0	3	2	4	1	3	1	1	2	3	1	1	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:150911327G>T	uc003eyp.2	+	14	2057	c.2019G>T	c.(2017-2019)TTG>TTT	p.L673F	MED12L_uc011bnz.1_Missense_Mutation_p.L533F|MED12L_uc003eyn.2_Missense_Mutation_p.L708F|MED12L_uc003eyo.2_Missense_Mutation_p.L673F	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	673					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACACTTCGTTGGGCAGAAGAA	0.388													97	97					2.15199e-58	3.37734e-58	1	0	T	150911327	T	T	150911327	3	4	39	1	0	0	0	0	1	0	0	0	9482	1339	47	4	2073	4	MED12L	3	150911327	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	20625467	150911327	47111103	102	8118											
SI	6476	broad.mit.edu	37	chr3	164741477	164741477	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttggaggtcagctgttatacCcatggatgaatagcgagctg	10	11	13	7	1	1	1	1	1	0	0	1	4	1	3	1	3	4	3	1	3	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:164741477C>T	uc003fei.2	-	26	3042	c.2980G>A	c.(2980-2982)GGT>AGT	p.G994S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	994	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GCTGTTATACCCATGGATGAA	0.403										HNSCC(35;0.089)			46	142					0	0	0	0	T	164741477	T	T	164741477	3	4	39	1	0	0	0	0	1	0	0	0	14362	623	22	4	2595	4	SI	3	164741477	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	13830150	164741477	33280953	103	8119											
LRRIQ4	344657	broad.mit.edu	37	chr3	169546666	169546666	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttagagaaattatacattggGcaagaccagggattcaaact	16	10	9	6	0	1	2	1	0	0	2	1	4	1	3	1	2	2	1	1	2	6	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:169546666G>T	uc003fgb.2	+	2	1140	c.1140G>T	c.(1138-1140)GGG>GGT	p.G380G		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	380	LRR 16.										0						TATACATTGGGCAAGACCAGG	0.438													36	167					9.45814e-24	1.33329e-23	1	0	T	169546666	T	T	169546666	2	4	39	1	0	0	0	0	0	0	0	1	9081	1190	42	4		4	LRRIQ4	3	169546666	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4805189	169546666	28475764	104	8120											
TNIK	23043	broad.mit.edu	37	chr3	170912383	170912383	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaccttttgtgttcttgatCaggtcggtgacagagccagc	7	14	11	9	1	2	3	1	2	1	1	3	3	2	3	2	2	3	1	2	2	1	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:170912383C>G	uc003fhh.2	-	5	693	c.348G>C	c.(346-348)CTG>CTC	p.L116L	TNIK_uc003fhi.2_Silent_p.L116L|TNIK_uc003fhj.2_Silent_p.L116L|TNIK_uc003fhk.2_Silent_p.L116L|TNIK_uc003fhl.2_Silent_p.L116L|TNIK_uc003fhm.2_Silent_p.L116L|TNIK_uc003fhn.2_Silent_p.L116L|TNIK_uc003fho.2_Silent_p.L116L	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	116	Protein kinase.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TGTTCTTGATCAGGTCGGTGA	0.468													173	197					0	0	0	0	G	170912383	G	G	170912383	2	3	39	1	0	0	0	0	0	0	0	1	16379	813	29	2		2	TNIK	3	170912383	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1365717	170912383	27110047	105	8121											
RFC4	5984	broad.mit.edu	37	chr3	186512478	186512478	+	Frame_Shift_Del	DEL	C	-	-																															tcctgacacagttaattgagCaaaatttttcactttctctc																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr3:186512478delC	uc003fqz.2	-	5	602	c.379delG	c.(379-381)GCTfs	p.A127fs	RFC4_uc011bsc.1_Frame_Shift_Del_p.A127fs|RFC4_uc011bsd.1_Frame_Shift_Del_p.A127fs	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	127					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		GTTAATTGAGCAAAATTTTTC	0.348													---	---	---								-	186512478	-	-	186512478	7	5	39	1	0	1	0	1	0	0	0	0	13312	710	25	0	740	0	RFC4	3	186512478	Frame_Shift_Del	DEL	C	TCGA-CN-4727-01A-01D-1434-08	15600095	186512478	11509952	106	8122											
PCGF3	10336	broad.mit.edu	37	chr4	737282	737282	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cggaaatgagaaagcagaggGagttctatcacaaattgggc	15	7	13	6	1	2	2	1	1	1	2	2	5	2	4	0	3	1	2	0	3	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:737282G>C	uc011bva.1	+	8	758	c.283G>C	c.(283-285)GAG>CAG	p.E95Q	PCGF3_uc003gbd.1_RNA|PCGF3_uc003gbe.2_Missense_Mutation_p.E95Q|PCGF3_uc010ibh.2_Missense_Mutation_p.E95Q|PCGF3_uc003gbg.1_Missense_Mutation_p.E61Q|PCGF3_uc003gbh.2_Missense_Mutation_p.E61Q	NM_006315	NP_006306	Q3KNV8	PCGF3_HUMAN	ring finger protein 3	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	zinc ion binding				0						AAAGCAGAGGGAGTTCTATCA	0.468													8	38					0	0	0	0	C	737282	C	C	737282	3	2	39	1	0	0	0	0	1	0	0	0	11630	1175	41	2	297	2	PCGF3	4	737282	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08		737282	190416994	107	8123											
CPLX1	10815	broad.mit.edu	37	chr4	786337	786337	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctcctcctccttcttggCggcgtctgggtccttctcct	0	14	9	18	3	3	0	0	0	3	0	8	0	7	0	6	3	0	1	6	3	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:786337C>A	uc003gbi.2	-	3	282	c.91G>T	c.(91-93)GCC>TCC	p.A31S	CPLX1_uc003gbj.2_Missense_Mutation_p.A31S	NM_006651	NP_006642	O14810	CPLX1_HUMAN	complexin 1	31	Potential.				glutamate secretion	cytosol					0				Colorectal(103;0.187)		TCCTTCTTGGCGGCGTCTGGG	0.657													31	113					4.31634e-10	5.07696e-10	1	0	A	786337	A	A	786337	3	1	39	1	0	0	0	0	1	0	0	0	3819	768	27	3	321	3	CPLX1	4	786337	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	49055	786337	190367939	108	8124											
ZFYVE28	57732	broad.mit.edu	37	chr4	2306406	2306406	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggcagttggtggccccaGtgctaagcttgtgggggccg	6	8	18	9	1	0	0	0	0	0	0	0	1	0	0	3	5	2	4	3	5	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:2306406G>T	uc003gex.1	-	8	1980	c.1661C>A	c.(1660-1662)ACT>AAT	p.T554N	ZFYVE28_uc011bvk.1_Missense_Mutation_p.T484N|ZFYVE28_uc011bvl.1_Missense_Mutation_p.T524N|ZFYVE28_uc003gew.1_Missense_Mutation_p.T440N	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	554					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						GGTGGCCCCAGTGCTAAGCTT	0.687													7	51					7.48243e-07	8.20845e-07	1	0	T	2306406	T	T	2306406	3	4	39	1	0	0	0	0	1	0	0	0	17737	1029	36	4	1026	4	ZFYVE28	4	2306406	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1520069	2306406	188847870	109	8125											
NOP14	8602	broad.mit.edu	37	chr4	2940652	2940652	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttactttccgctttctttccGcatccctaaaagaaacaaaa	13	13	3	12	2	1	1	0	0	1	1	4	1	4	1	3	0	2	2	3	0	6	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:2940652G>A	uc003ggj.1	-	18	2552	c.2480C>T	c.(2479-2481)GCG>GTG	p.A827V	C4orf10_uc003ggd.1_Intron|C4orf10_uc003gge.1_Intron|C4orf10_uc003ggg.1_Intron|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Intron|NOP14_uc003ggk.3_Intron|NOP14_uc003ggl.2_Missense_Mutation_p.A827V	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	827					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						CTTTCTTTCCGCATCCCTAAA	0.428													4	134					0	0	0	0	A	2940652	A	A	2940652	3	1	39	1	0	0	0	0	1	0	0	0	10590	1087	38	1	97	1	NOP14	4	2940652	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	634246	2940652	188213624	110	8126											
PI4K2B	55300	broad.mit.edu	37	chr4	25256888	25256888	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcattgtacctaaaacaaagGtaagccagactttattttta	15	13	6	7	0	0	1	0	0	0	1	0	1	0	1	2	1	3	3	2	1	7	9			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:25256888G>A	uc003grk.2	+	3	757	c.624_splice	c.e3+1	p.K208_splice	PI4K2B_uc011bxs.1_Splice_Site_p.K112_splice	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta							cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			ovary(2)|skin(2)	4		Breast(46;0.173)				TAAAACAAAGGTAAGCCAGAC	0.403													29	107					0	0	0	0	A	25256888	A	A	25256888	5	1	39	1	0	0	0	0	0	0	1	0	11927	1275	44	4	635	4	PI4K2B	4	25256888	Splice_Site	SNP	G	TCGA-CN-4727-01A-01D-1434-08	22316236	25256888	165897388	111	8127											
SEL1L3	23231	broad.mit.edu	37	chr4	25780751	25780751	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccaggttgcctgtgatataGtagagagaacaccacaaggt	13	9	11	8	0	0	3	0	1	0	2	1	4	1	3	3	2	2	2	3	2	5	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:25780751G>A	uc003gru.3	-	16	2684	c.2532C>T	c.(2530-2532)TAC>TAT	p.Y844Y	SEL1L3_uc003grv.2_Silent_p.Y251Y	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	844	Sel1-like 7.					integral to membrane	binding				0						CTGTGATATAGTAGAGAGAAC	0.443													24	114					0	0	0	0	A	25780751	A	A	25780751	2	1	39	1	0	0	0	0	0	0	0	1	14077	1024	36	4		4	SEL1L3	4	25780751	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	523863	25780751	165373525	112	8128											
GABRG1	2565	broad.mit.edu	37	chr4	46060593	46060593	+	Frame_Shift_Del	DEL	G	-	-																															ttaggatcagccacttctacGgagggctttttccacttata																								rs139684526	byFrequency	TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:46060593delG	uc003gxb.2	-	6	824	c.672delC	c.(670-672)TCCfs	p.S224fs		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	224	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CCACTTCTACGGAGGGCTTTT	0.353													---	---	---								-	46060593	-	-	46060593	7	5	39	1	0	1	0	1	0	0	0	0	6205	1103	39	0	741	0	GABRG1	4	46060593	Frame_Shift_Del	DEL	G	TCGA-CN-4727-01A-01D-1434-08	20279842	46060593	145093683	113	8129											
TMEM165	55858	broad.mit.edu	37	chr4	56283323	56283323	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttgccatttttggcattaGaatgcttcgggaaggcttaa	10	15	10	6	1	0	1	0	0	0	1	1	2	0	2	1	3	2	3	1	3	4	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:56283323G>C	uc003hax.2	+	3	785	c.518G>C	c.(517-519)AGA>ACA	p.R173T	TMEM165_uc011bzy.1_Missense_Mutation_p.R110T	NM_018475	NP_060945	Q9HC07	TM165_HUMAN	transmembrane protein 165	173						integral to membrane					0	Lung NSC(11;0.00545)|Glioma(25;0.08)|all_neural(26;0.101)|all_epithelial(27;0.135)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0103)			TTTGGCATTAGAATGCTTCGG	0.398													37	178					0	0	0	0	C	56283323	C	C	56283323	3	2	39	1	0	0	0	0	1	0	0	0	16146	942	33	2	528	2	TMEM165	4	56283323	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	10222730	56283323	134870953	114	8130											
TMEM165	55858	broad.mit.edu	37	chr4	56283406	56283406	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctgaattaaagaagaaaGatgaagaagtaagccatggc	20	6	11	4	0	0	6	0	2	0	4	0	6	0	6	1	1	2	2	1	1	9	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:56283406G>C	uc003hax.2	+	3	868	c.601G>C	c.(601-603)GAT>CAT	p.D201H	TMEM165_uc011bzy.1_Missense_Mutation_p.D138H	NM_018475	NP_060945	Q9HC07	TM165_HUMAN	transmembrane protein 165	201						integral to membrane					0	Lung NSC(11;0.00545)|Glioma(25;0.08)|all_neural(26;0.101)|all_epithelial(27;0.135)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0103)			AAAGAAGAAAGATGAAGAAGT	0.438													26	118					0	0	0	0	C	56283406	C	C	56283406	3	2	39	1	0	0	0	0	1	0	0	0	16146	942	33	2	611	2	TMEM165	4	56283406	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	83	56283406	134870870	115	8131											
NPFFR2	10886	broad.mit.edu	37	chr4	72897871	72897871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaacctgttgctgcagacggGcttggtggattctggttcct	5	13	14	9	1	1	1	0	0	1	1	2	3	2	2	2	4	3	5	2	4	1	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:72897871G>A	uc003hgg.2	+	1	351	c.253G>A	c.(253-255)GCT>ACT	p.A85T	NPFFR2_uc010iig.1_5'UTR	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	85	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			CTGCAGACGGGCTTGGTGGAT	0.672													14	29					0	0	0	0	A	72897871	A	A	72897871	3	1	39	1	0	0	0	0	1	0	0	0	10632	1203	42	4	255	4	NPFFR2	4	72897871	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	16614465	72897871	118256405	116	8132											
NPFFR2	10886	broad.mit.edu	37	chr4	73012843	73012843	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaaaatattaccgagtgAgactcaactcccagaataaa	20	7	6	8	1	1	3	1	1	0	3	2	5	2	3	2	0	2	0	2	0	9	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:73012843A>G	uc003hgg.2	+	4	981	c.883A>G	c.(883-885)AGA>GGA	p.R295G	NPFFR2_uc010iig.1_Missense_Mutation_p.R77G|NPFFR2_uc003hgi.2_Missense_Mutation_p.R196G|NPFFR2_uc003hgh.2_Missense_Mutation_p.R193G|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	295	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TTACCGAGTGAGACTCAACTC	0.438													87	212					0	0	0	0	G	73012843	G	G	73012843	3	3	39	1	0	0	0	0	1	0	0	0	10632	296	11	5	903	5	NPFFR2	4	73012843	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	114972	73012843	118141433	117	8133											
RASGEF1B	153020	broad.mit.edu	37	chr4	82380494	82380494	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgaatacctacatctggatAgtaatccacattaggtacta	15	12	6	8	0	1	1	0	1	1	0	2	2	2	2	2	2	3	2	2	2	8	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:82380494A>T	uc003hmi.1	-	2	313	c.169T>A	c.(169-171)TAT>AAT	p.Y57N	RASGEF1B_uc003hmj.1_Missense_Mutation_p.Y57N|RASGEF1B_uc010ijq.1_Missense_Mutation_p.Y57N|RASGEF1B_uc003hmk.2_Missense_Mutation_p.Y57N	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	57	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						ACATCTGGATAGTAATCCACA	0.428													89	173					0	0	0	0	T	82380494	T	T	82380494	3	4	39	1	0	0	0	0	1	0	0	0	13135	420	15	5	1304	5	RASGEF1B	4	82380494	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	9367651	82380494	108773782	118	8134											
AFF1	4299	broad.mit.edu	37	chr4	88036203	88036203	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagccgtggtggtccaggagGacagccgcaaagacagactc	12	4	14	11	2	0	2	0	0	0	2	2	4	1	4	3	4	2	1	3	4	2	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:88036203G>A	uc003hqj.3	+	11	2604	c.2197G>A	c.(2197-2199)GAC>AAC	p.D733N	AFF1_uc011ccz.1_Missense_Mutation_p.D740N|AFF1_uc003hqk.3_Missense_Mutation_p.D733N|AFF1_uc011cda.1_Missense_Mutation_p.D371N	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	733						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GGTCCAGGAGGACAGCCGCAA	0.607													16	30					0	0	0	0	A	88036203	A	A	88036203	3	1	39	1	0	0	0	0	1	0	0	0	356	1174	41	2	2281	2	AFF1	4	88036203	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	5655709	88036203	103118073	119	8135											
C4orf21	55345	broad.mit.edu	37	chr4	113540786	113540786	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttagcctcatgtgatgcagCtgattcaccactttccataa	10	13	6	12	0	2	2	2	2	0	0	3	2	3	2	3	0	3	2	3	0	2	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:113540786C>A	uc003iau.2	-	6	623	c.412G>T	c.(412-414)GCT>TCT	p.A138S	C4orf21_uc003iaw.2_Missense_Mutation_p.A138S	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TGTGATGCAGCTGATTCACCA	0.388													37	105					4.17593e-13	5.21051e-13	1	0	A	113540786	A	A	113540786	3	1	39	1	0	0	0	0	1	0	0	0	2264	797	28	4	5994	4	C4orf21	4	113540786	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	25504583	113540786	77613490	120	8136											
ANK2	287	broad.mit.edu	37	chr4	114238951	114238951	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggatgactcagttgtgAttcccagtcaccaggtatgt	9	13	11	8	0	2	3	2	3	0	0	3	4	3	4	2	2	0	2	2	2	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:114238951A>G	uc003ibe.3	+	25	2882	c.2782A>G	c.(2782-2784)ATT>GTT	p.I928V	ANK2_uc003ibd.3_Missense_Mutation_p.I907V|ANK2_uc003ibf.3_Missense_Mutation_p.I928V|ANK2_uc011cgc.1_Missense_Mutation_p.I137V|ANK2_uc003ibg.3_5'Flank|ANK2_uc003ibc.2_Missense_Mutation_p.I904V|ANK2_uc011cgb.1_Missense_Mutation_p.I943V	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	928					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTCAGTTGTGATTCCCAGTCA	0.473													37	69					0	0	0	0	G	114238951	G	G	114238951	3	3	39	1	0	0	0	0	1	0	0	0	621	333	12	5	2905	5	ANK2	4	114238951	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	698165	114238951	76915325	121	8137											
FABP2	2169	broad.mit.edu	37	chr4	120243419	120243420	+	5'Flank	INS	-	TT	TT																															caattaattaattcttattaINSattaattcttaattctcgtt																								rs151066719	by1000genomes	TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:120243419_120243420insTT	uc003icw.2	-							NM_000134	NP_000125	P12104	FABPI_HUMAN	intestinal fatty acid binding protein 2								fatty acid binding			ovary(1)	1						AATTCTTATTAATTAATTCTTA	0.287													---	---	---								TT	120243420	TT	TT	120243419	6	5	39	0	1	1	1	0	0	0	0	0	5385	377	13	0		0	FABP2	4	120243419	5'Flank	INS	-	TCGA-CN-4727-01A-01D-1434-08	6004468	120243419	70910857	122	8138											
GYPA	2993	broad.mit.edu	37	chr4	145039886	145039886	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctggttcagagaaatgatgGgcaagttgtaccctttctcc	9	12	10	10	0	2	2	1	1	1	1	3	3	2	2	3	2	1	4	3	2	3	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:145039886G>T	uc003ijo.3	-	4	368	c.252C>A	c.(250-252)GCC>GCA	p.A84A	GYPA_uc003ijn.2_Silent_p.A84A|GYPA_uc011cia.1_RNA|GYPA_uc011cib.1_Silent_p.A51A|GYPA_uc003ijp.3_Silent_p.A52A|GYPA_uc010ioq.2_Intron|GYPA_uc010ior.2_Silent_p.A19A|GYPA_uc010ios.1_Intron	NM_002099	NP_002090	P02724	GLPA_HUMAN	glycophorin A precursor	84	Extracellular.		A -> P (in ENEP/HAG antigen).		interspecies interaction between organisms	membrane fraction	receptor activity	p.A84T(1)		central_nervous_system(2)	2	all_hematologic(180;0.15)					AGAAATGATGGGCAAGTTGTA	0.313													44	129					8.30282e-39	1.26367e-38	1	0	T	145039886	T	T	145039886	2	4	39	1	0	0	0	0	0	0	0	1	6947	1219	43	4		4	GYPA	4	145039886	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	24796467	145039886	46114390	123	8139											
OTUD4	54726	broad.mit.edu	37	chr4	146071685	146071685	+	Frame_Shift_Del	DEL	C	-	-																															cttatgatctgtgaaggtgtCcggctaagatttttgtgctc																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:146071685delC	uc003ika.3	-	13	1182	c.1044delG	c.(1042-1044)CGGfs	p.R348fs	OTUD4_uc003ijz.3_Frame_Shift_Del_p.R347fs	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	412							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					GTGAAGGTGTCCGGCTAAGAT	0.398													---	---	---								-	146071685	-	-	146071685	7	5	39	1	0	1	0	1	0	0	0	0	11368	842	30	0	2141	0	OTUD4	4	146071685	Frame_Shift_Del	DEL	C	TCGA-CN-4727-01A-01D-1434-08	1031799	146071685	45082591	124	8140											
DCHS2	54798	broad.mit.edu	37	chr4	155256095	155256095	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataaactaagaaagtgtactTaggcctttcaaactcagcag	16	10	7	8	0	2	1	2	0	0	1	2	1	2	1	1	1	4	2	1	1	7	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:155256095T>A	uc003inw.2	-	8	1141	c.1141A>T	c.(1141-1143)AAG>TAG	p.K381*	DCHS2_uc003inx.2_Nonsense_Mutation_p.K880*	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	381	Cadherin 3.|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AAAGTGTACTTAGGCCTTTCA	0.448													60	115					0	0	0	0	A	155256095	A	A	155256095	4	1	39	1	0	0	0	0	0	1	0	0	4305	1763	61	5	7777	5	DCHS2	4	155256095	Nonsense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	9184410	155256095	35898181	125	8141											
DDX60	55601	broad.mit.edu	37	chr4	169201720	169201720	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccttttcttattctctctagCaattatttcagccttggtct	6	20	4	11	0	5	0	1	0	4	0	6	0	5	0	2	1	2	1	2	1	4	8			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:169201720C>A	uc003irp.2	-	14	2036	c.1744G>T	c.(1744-1746)GCT>TCT	p.A582S		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	582							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TTCTCTCTAGCAATTATTTCA	0.348													20	57					0.000229342	0.000243401	1	0	A	169201720	A	A	169201720	3	1	39	1	0	0	0	0	1	0	0	0	4395	710	25	4	3494	4	DDX60	4	169201720	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	13945625	169201720	21952556	126	8142											
DDX60L	91351	broad.mit.edu	37	chr4	169348297	169348297	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaactccaaatttcactgaAttacttgcacatgatgtcaa	14	13	4	10	0	3	2	3	2	0	0	4	2	4	2	1	0	3	1	1	0	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:169348297A>G	uc003irq.3	-	14	2075	c.1854T>C	c.(1852-1854)AAT>AAC	p.N618N	DDX60L_uc003irr.1_Silent_p.N618N|DDX60L_uc003irs.1_Silent_p.N345N	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	618							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		ATTTCACTGAATTACTTGCAC	0.353													14	26					0	0	0	0	G	169348297	G	G	169348297	2	3	39	1	0	0	0	0	0	0	0	1	4396	98	4	5		5	DDX60L	4	169348297	Silent	SNP	A	TCGA-CN-4727-01A-01D-1434-08	146577	169348297	21805979	127	8143											
ADAM29	11086	broad.mit.edu	37	chr4	175896751	175896751	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cacatccaggatgagcacccCcaatatcacagccctccgga	12	5	7	17	1	1	1	1	1	0	0	3	3	3	3	5	2	2	1	5	2	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:175896751C>T	uc003iuc.2	+	5	745	c.75C>T	c.(73-75)CCC>CCT	p.P25P	ADAM29_uc003iud.2_Silent_p.P25P|ADAM29_uc010irr.2_Silent_p.P25P|ADAM29_uc011cki.1_Silent_p.P25P	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	25					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ATGAGCACCCCCAATATCACA	0.517													51	114					0	0	0	0	T	175896751	T	T	175896751	2	4	39	1	0	0	0	0	0	0	0	1	247	610	22	4		4	ADAM29	4	175896751	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	6548454	175896751	15257525	128	8144											
ASB5	140458	broad.mit.edu	37	chr4	177142615	177142615	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttacctttactggcggccTcatgcgttggggatggaaga	8	11	14	8	2	1	1	1	0	0	1	1	3	1	3	2	5	3	2	2	5	3	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:177142615T>C	uc003iuq.1	-	4	537	c.521A>G	c.(520-522)GAG>GGG	p.E174G	ASB5_uc003iup.1_Missense_Mutation_p.E121G	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	174	ANK 4.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		ACTGGCGGCCTCATGCGTTGG	0.493													42	219					0	0	0	0	C	177142615	C	C	177142615	3	2	39	1	0	0	0	0	1	0	0	0	1028	1551	54	5	484	5	ASB5	4	177142615	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	1245864	177142615	14011661	129	8145											
NEIL3	55247	broad.mit.edu	37	chr4	178283595	178283595	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttccagtgggcagaaaatggGccaggaataaaaattattcc	15	9	10	7	0	0	1	0	0	0	1	2	2	2	2	3	3	0	1	3	3	7	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr4:178283595G>T	uc003iut.2	+	10	1905	c.1788G>T	c.(1786-1788)GGG>GGT	p.G596G		NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	596					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		CAGAAAATGGGCCAGGAATAA	0.363								BER_DNA_glycosylases					51	123					1.0442e-30	1.51834e-30	1	0	T	178283595	T	T	178283595	2	4	39	1	0	0	0	0	0	0	0	1	10374	1190	42	4		4	NEIL3	4	178283595	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1140980	178283595	12870681	130	8146											
LPCAT1	79888	broad.mit.edu	37	chr5	1474683	1474683	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaggtactcacccgaggccCcgcacgagcctggcaaattc	9	5	10	17	3	1	0	1	0	0	0	2	2	1	0	5	3	2	3	5	3	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:1474683C>A	uc003jcm.2	-	10	1134	c.1017G>T	c.(1015-1017)CGG>CGT	p.R339R		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	339	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		ACCCGAGGCCCCGCACGAGCC	0.612													24	24					9.86323e-18	1.30101e-17	1	0	A	1474683	A	A	1474683	2	1	39	1	0	0	0	0	0	0	0	1	8960	610	22	4		4	LPCAT1	5	1474683	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08		1474683	179440577	131	8147											
ADCY2	108	broad.mit.edu	37	chr5	7727344	7727344	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtctcatattcttctgcaTcttcattgtgcagattctcg	6	18	6	11	1	6	1	2	0	5	1	8	1	6	1	0	0	2	2	0	0	1	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:7727344T>A	uc003jdz.1	+	14	1908	c.1841T>A	c.(1840-1842)ATC>AAC	p.I614N	ADCY2_uc011cmo.1_Missense_Mutation_p.I434N	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	614	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TTCTTCTGCATCTTCATTGTG	0.493													67	80					0	0	0	0	A	7727344	A	A	7727344	3	1	39	1	0	0	0	0	1	0	0	0	294	1435	50	5	1895	5	ADCY2	5	7727344	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	6252661	7727344	173187916	132	8148											
CCT5	22948	broad.mit.edu	37	chr5	10262656	10262656	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcatccggaacctcatccgcGataatcgtgtggtgtatgga	9	11	11	10	4	2	0	2	0	0	0	5	3	4	2	3	3	1	1	3	3	3	2	rs11557654		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:10262656G>A	uc003jeq.2	+	9	1414	c.1243G>A	c.(1243-1245)GAT>AAT	p.D415N	CCT5_uc003jer.2_Missense_Mutation_p.D415N|CCT5_uc010its.2_Missense_Mutation_p.D415N|CCT5_uc011cmr.1_Missense_Mutation_p.D360N|CCT5_uc011cms.1_Missense_Mutation_p.D377N|CCT5_uc011cmt.1_Missense_Mutation_p.D322N	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	415					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						CCTCATCCGCGATAATCGTGT	0.493													30	135					0	0	0	0	A	10262656	A	A	10262656	3	1	39	1	0	0	0	0	1	0	0	0	2971	1058	37	1	1277	1	CCT5	5	10262656	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2535312	10262656	170652604	133	8149											
DNAH5	1767	broad.mit.edu	37	chr5	13721328	13721328	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcggcatatttttctccCatggagtccacgatgtactt	7	15	7	12	2	1	0	0	0	1	0	4	2	2	1	3	2	1	2	3	2	2	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:13721328C>A	uc003jfd.2	-	71	12102	c.12060G>T	c.(12058-12060)ATG>ATT	p.M4020I	DNAH5_uc003jfc.2_Missense_Mutation_p.M188I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4020	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATTTTTCTCCCATGGAGTCCA	0.393									Kartagener_syndrome				71	81					2.29502e-22	3.17068e-22	1	0	A	13721328	A	A	13721328	3	1	39	1	0	0	0	0	1	0	0	0	4626	594	21	4	1850	4	DNAH5	5	13721328	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3458672	13721328	167193932	134	8150											
DNAH5	1767	broad.mit.edu	37	chr5	13792157	13792157	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcattccctgccagacccgAgaaagatctcgtaggttaaa	13	8	9	11	2	1	3	0	0	1	3	3	4	2	3	3	1	2	3	3	1	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:13792157A>G	uc003jfd.2	-	50	8436	c.8394T>C	c.(8392-8394)TCT>TCC	p.S2798S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2798	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCCAGACCCGAGAAAGATCTC	0.408									Kartagener_syndrome				13	80					0	0	0	0	G	13792157	G	G	13792157	2	3	39	1	0	0	0	0	0	0	0	1	4626	291	11	5		5	DNAH5	5	13792157	Silent	SNP	A	TCGA-CN-4727-01A-01D-1434-08	70829	13792157	167123103	135	8151											
CDH12	1010	broad.mit.edu	37	chr5	21755861	21755861	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctgctctggacagggtagCtgctgtcttctattacaaca	8	13	10	10	0	3	0	0	0	3	0	3	1	3	1	0	2	6	5	0	2	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:21755861C>G	uc010iuc.2	-	11	2182	c.1724G>C	c.(1723-1725)AGC>ACC	p.S575T	CDH12_uc011cno.1_Missense_Mutation_p.S535T|CDH12_uc003jgk.2_Missense_Mutation_p.S575T|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	575	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GACAGGGTAGCTGCTGTCTTC	0.453										HNSCC(59;0.17)			31	139					0	0	0	0	G	21755861	G	G	21755861	3	3	39	1	0	0	0	0	1	0	0	0	3113	797	28	4	668	4	CDH12	5	21755861	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	7963704	21755861	159159399	136	8152											
PRDM9	56979	broad.mit.edu	37	chr5	23522816	23522816	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcagtggacaaggggcaccCcaaccgttcagccctcagtc	9	6	11	15	1	2	0	2	0	0	0	3	1	2	1	4	3	3	3	4	3	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:23522816C>G	uc003jgo.2	+	8	886	c.704C>G	c.(703-705)CCC>CGC	p.P235R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	235					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AAGGGGCACCCCAACCGTTCA	0.562										HNSCC(3;0.000094)			30	55					0	0	0	0	G	23522816	G	G	23522816	3	3	39	1	0	0	0	0	1	0	0	0	12525	623	22	4	730	4	PRDM9	5	23522816	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1766955	23522816	157392444	137	8153											
PRDM9	56979	broad.mit.edu	37	chr5	23527713	23527713	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtctgcagggagtgtgggcGgggctttcgcaataagtcac	7	10	16	8	2	2	0	1	0	1	0	3	1	2	1	0	4	1	3	0	4	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:23527713G>A	uc003jgo.2	+	11	2698	c.2516G>A	c.(2515-2517)CGG>CAG	p.R839Q		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	839	C2H2-type 13.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GAGTGTGGGCGGGGCTTTCGC	0.592										HNSCC(3;0.000094)			70	188					0	0	0	0	A	23527713	A	A	23527713	3	1	39	1	0	0	0	0	1	0	0	0	12525	1116	39	1	2554	1	PRDM9	5	23527713	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4897	23527713	157387547	138	8154											
PRLR	5618	broad.mit.edu	37	chr5	35065550	35065550	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacataatccaagggtttagCggagccaaagggggttttct	11	10	12	8	1	1	0	0	0	1	0	2	1	2	1	2	4	2	2	2	4	4	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:35065550C>A	uc003jjm.2	-	10	2040	c.1510G>T	c.(1510-1512)GCT>TCT	p.A504S	PRLR_uc003jjg.1_Intron|PRLR_uc003jjh.1_Intron|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Intron|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Missense_Mutation_p.A403S	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	504	Cytoplasmic (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AAGGGTTTAGCGGAGCCAAAG	0.522													72	160					4.14589e-37	6.24137e-37	1	0	A	35065550	A	A	35065550	3	1	39	1	0	0	0	0	1	0	0	0	12593	768	27	3	362	3	PRLR	5	35065550	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	11537837	35065550	145849710	139	8155											
LIFR	3977	broad.mit.edu	37	chr5	38486048	38486048	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagtgtcttctgggatatGtcagtaatattcttaacttt	9	18	7	7	0	5	0	2	0	3	0	5	1	5	1	0	1	1	1	0	1	4	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:38486048G>A	uc010ive.1	-	17	2702	c.2370C>T	c.(2368-2370)GAC>GAT	p.D790D	LIFR_uc003jli.2_Silent_p.D790D	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	790	Fibronectin type-III 6.|Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					TCTGGGATATGTCAGTAATAT	0.408			T	PLAG1	salivary adenoma								14	74					0	0	0	0	A	38486048	A	A	38486048	2	1	39	1	0	0	0	0	0	0	0	1	8821	1368	48	4		4	LIFR	5	38486048	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	3420498	38486048	142429212	140	8156											
FYB	2533	broad.mit.edu	37	chr5	39135036	39135036	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atttcaatttgctctccttgCttgaagctcagttcattctt	7	19	5	10	0	5	1	3	1	2	0	6	1	5	1	1	0	3	4	1	0	2	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:39135036C>T	uc003jls.2	-	7	1663	c.1596G>A	c.(1594-1596)AAG>AAA	p.K532K	FYB_uc003jlt.2_Silent_p.K532K|FYB_uc003jlu.2_Silent_p.K532K|FYB_uc011cpl.1_Silent_p.K542K	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	532	SH3.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			GCTCTCCTTGCTTGAAGCTCA	0.423													60	85					0	0	0	0	T	39135036	T	T	39135036	2	4	39	1	0	0	0	0	0	0	0	1	6158	796	28	4		4	FYB	5	39135036	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	648988	39135036	141780224	141	8157											
C7	730	broad.mit.edu	37	chr5	40931225	40931225	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cccttggtcagaatgcaatgGctgtaccaagactcaggtag	11	9	11	10	0	2	2	2	0	0	2	2	2	2	2	2	3	2	4	2	3	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:40931225G>A	uc003jmh.2	+	3	236	c.122G>A	c.(121-123)GGC>GAC	p.G41D	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	41	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				GAATGCAATGGCTGTACCAAG	0.423													25	54					0	0	0	0	A	40931225	A	A	40931225	3	1	39	1	0	0	0	0	1	0	0	0	2386	1203	42	4	132	4	C7	5	40931225	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1796189	40931225	139984035	142	8158											
MSH3	4437	broad.mit.edu	37	chr5	80168934	80168934	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctcctttctttatttcacaGgcgcagcagaacaagtccct	9	13	6	13	1	3	1	1	0	2	1	5	1	4	1	2	1	2	2	2	1	3	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:80168934G>T	uc003kgz.2	+	23	3384	c.3131_splice	c.e23-1	p.G1044_splice		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3						maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		TTATTTCACAGGCGCAGCAGA	0.363								MMR					38	120					4.17593e-13	5.21051e-13	1	0	T	80168934	T	T	80168934	5	4	39	1	0	0	0	0	0	0	1	0	9924	1014	35	4	3220	4	MSH3	5	80168934	Splice_Site	SNP	G	TCGA-CN-4727-01A-01D-1434-08	39237709	80168934	100746326	143	8159											
MEF2C	4208	broad.mit.edu	37	chr5	88027668	88027668	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catattcttgttcaagttacCaggtgagaccagcagacctg	11	11	9	10	0	2	2	1	1	1	2	2	3	2	2	3	1	2	3	3	1	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:88027668C>T	uc003kjj.2	-	7	1361	c.688G>A	c.(688-690)GGT>AGT	p.G230S	MEF2C_uc003kji.2_Missense_Mutation_p.G230S|MEF2C_uc003kjk.2_Missense_Mutation_p.G230S|MEF2C_uc003kjm.2_Missense_Mutation_p.G228S|MEF2C_uc003kjl.2_Missense_Mutation_p.G248S	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	230					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		TTCAAGTTACCAGGTGAGACC	0.423										HNSCC(66;0.2)			10	36					0	0	0	0	T	88027668	T	T	88027668	3	4	39	1	0	0	0	0	1	0	0	0	9510	594	21	4	753	4	MEF2C	5	88027668	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	7858734	88027668	92887592	144	8160											
GPR98	84059	broad.mit.edu	37	chr5	90073745	90073745	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcgaggcccagggatttTgggggaggtcacagtgttct	6	12	16	7	1	2	0	1	0	1	0	3	3	2	2	1	5	0	2	1	5	0	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:90073745T>C	uc003kju.2	+	62	12647	c.12551T>C	c.(12550-12552)TTG>TCG	p.L4184S	GPR98_uc003kjt.2_Missense_Mutation_p.L1890S	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4184	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCAGGGATTTTGGGGGAGGTC	0.423													13	43					0	0	0	0	C	90073745	C	C	90073745	3	2	39	1	0	0	0	0	1	0	0	0	6760	1821	63	5	12797	5	GPR98	5	90073745	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	2046077	90073745	90841515	145	8161											
MCTP1	79772	broad.mit.edu	37	chr5	94619883	94619883	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccgccgcgggcccctttaCggcggggagcaaatgctcgc	5	5	16	15	6	0	0	0	0	0	0	1	1	0	1	4	5	3	2	4	5	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:94619883C>A	uc003kkx.2	-	1	397	c.397G>T	c.(397-399)GTA>TTA	p.V133L		NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	133					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		GGCCCCTTTACGGCGGGGAGC	0.602													4	5					1.23904e-05	1.33546e-05	1	0	A	94619883	A	A	94619883	3	1	39	1	0	0	0	0	1	0	0	0	9453	536	19	3	2755	3	MCTP1	5	94619883	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4546138	94619883	86295377	146	8162											
SLCO4C1	353189	broad.mit.edu	37	chr5	101597728	101597728	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcgcggatcatcctcagtGacatcagtgctatatgatag	11	11	9	10	2	3	2	3	2	0	0	5	3	4	3	1	1	1	1	1	1	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:101597728G>T	uc003knm.2	-	5	1196	c.909C>A	c.(907-909)GTC>GTA	p.V303V		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	303	Extracellular (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		CATCCTCAGTGACATCAGTGC	0.358													13	52					1.5842e-08	1.80586e-08	1	0	T	101597728	T	T	101597728	2	4	39	1	0	0	0	0	0	0	0	1	14794	1277	45	2		2	SLCO4C1	5	101597728	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	6977845	101597728	79317532	147	8163											
PPIP5K2	23262	broad.mit.edu	37	chr5	102491630	102491630	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caggtatggtcatttttctgGaataaatcgtaaggttcagt	11	15	10	5	1	3	0	2	0	1	0	4	1	3	1	0	4	0	3	0	4	5	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:102491630G>A	uc003kod.3	+	14	1940	c.1421G>A	c.(1420-1422)GGA>GAA	p.G474E	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.G474E|PPIP5K2_uc010jbo.1_Missense_Mutation_p.G396E	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	474					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						CATTTTTCTGGAATAAATCGT	0.333													18	34					0	0	0	0	A	102491630	A	A	102491630	3	1	39	1	0	0	0	0	1	0	0	0	12393	1174	41	2	1471	2	PPIP5K2	5	102491630	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	893902	102491630	78423630	148	8164											
STARD4	134429	broad.mit.edu	37	chr5	110835766	110835766	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggatggttatatcctcgaaCaaattctggtctcttttcat	9	16	8	8	1	3	0	1	0	2	0	6	2	4	1	1	3	1	1	1	3	4	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:110835766C>T	uc003kph.1	-	6	520	c.436G>A	c.(436-438)GTT>ATT	p.V146I	STARD4_uc010jbw.1_Missense_Mutation_p.V48I|STARD4_uc010jbx.1_Missense_Mutation_p.V48I|STARD4_uc003kpi.1_RNA	NM_139164	NP_631903	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain	146	START.				lipid transport		lipid binding			ovary(1)	1		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		TATCCTCGAACAAATTCTGGT	0.363													23	72					0	0	0	0	T	110835766	T	T	110835766	3	4	39	1	0	0	0	0	1	0	0	0	15325	478	17	4	185	4	STARD4	5	110835766	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	8344136	110835766	70079494	149	8165											
AQPEP	206338	broad.mit.edu	37	chr5	115298688	115298688	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagcttccggccgggtcttTgcccttcactggccgcgtga	3	10	13	15	5	2	1	1	1	1	0	3	2	3	1	4	3	2	1	4	3	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:115298688T>C	uc003kro.2	+	1	538	c.374T>C	c.(373-375)TTG>TCG	p.L125S	AQPEP_uc003krp.2_RNA|uc003krn.1_5'UTR	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	125	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						GCCGGGTCTTTGCCCTTCACT	0.687													28	87					0	0	0	0	C	115298688	C	C	115298688	3	2	39	1	0	0	0	0	1	0	0	0	834	1821	63	5	376	5	AQPEP	5	115298688	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	4462922	115298688	65616572	150	8166											
SLC22A4	6583	broad.mit.edu	37	chr5	131630517	131630517	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaacaacagtgtcccgctgCggctgcgggacggccgcgag	7	4	16	14	6	0	0	0	0	0	0	1	2	1	1	2	3	4	3	2	3	2	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:131630517C>A	uc003kwq.2	+	1	373	c.208C>A	c.(208-210)CGG>AGG	p.R70R	uc003kwm.3_Intron|SLC22A4_uc010jdq.1_5'Flank	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	70	Extracellular (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	TGTCCCGCTGCGGCTGCGGGA	0.721													6	23					2.0095e-06	2.18715e-06	1	0	A	131630517	A	A	131630517	2	1	39	1	0	0	0	0	0	0	0	1	14520	759	27	3		3	SLC22A4	5	131630517	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	16331829	131630517	49284743	151	8167											
MYOT	9499	broad.mit.edu	37	chr5	137206561	137206561	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctttccctgcttctcccaAgcagcatgctggctccaacc	6	11	7	17	0	1	0	0	0	1	0	4	0	3	0	4	1	6	6	4	1	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:137206561A>T	uc011cye.1	+	2	238	c.221A>T	c.(220-222)AAG>ATG	p.K74M	MYOT_uc003lbv.2_Missense_Mutation_p.Q74L|MYOT_uc011cyg.1_Intron|MYOT_uc011cyh.1_Intron	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	74					muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCTTCTCCCAAGCAGCATGCT	0.532													32	80					0	0	0	0	T	137206561	T	T	137206561	3	4	39	1	0	0	0	0	1	0	0	0	10147	72	3	5	223	5	MYOT	5	137206561	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	5576044	137206561	43708699	152	8168											
PCDHA2	56146	broad.mit.edu	37	chr5	140175845	140175845	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgcacgggacgggggctcGccttcactgtgggccaccac	6	5	14	16	4	1	0	1	0	0	0	2	1	1	1	4	4	0	2	4	4	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:140175845G>A	uc003lhd.2	+	1	1402	c.1296G>A	c.(1294-1296)TCG>TCA	p.S432S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.S432S|PCDHA2_uc011czy.1_Silent_p.S432S	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	432	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGGGGCTCGCCTTCACTGT	0.627													28	78					0	0	0	0	A	140175845	A	A	140175845	2	1	39	1	0	0	0	0	0	0	0	1	11578	1074	38	1		1	PCDHA2	5	140175845	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2969284	140175845	40739415	153	8169											
PCDHA3	56145	broad.mit.edu	37	chr5	140182638	140182638	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcctgggaccggcggtgcgcGcatcccgtttcgcgtggggc	2	7	18	14	7	0	0	0	0	0	0	2	1	1	1	3	5	1	2	3	5	0	1	rs146046778		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:140182638G>A	uc003lhf.2	+	1	1856	c.1856G>A	c.(1855-1857)CGC>CAC	p.R619H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.R619H	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	619	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGGTGCGCGCATCCCGTTT	0.672													4	70					0	0	0	0	A	140182638	A	A	140182638	3	1	39	1	0	0	0	0	1	0	0	0	11579	1087	38	1	1858	1	PCDHA3	5	140182638	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	6793	140182638	40732622	154	8170											
PCDHA5	56143	broad.mit.edu	37	chr5	140203530	140203530	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acaccgcgctgcggtgctcgGcgcagcccaccgaggccgtg	5	4	15	17	7	0	0	0	0	0	0	1	1	0	0	4	3	3	3	4	3	0	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:140203530G>T	uc003lhl.2	+	1	2170	c.2170G>T	c.(2170-2172)GCG>TCG	p.A724S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.A724S|PCDHA5_uc003lhj.1_Missense_Mutation_p.A724S	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	724	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGTGCTCGGCGCAGCCCAC	0.657													24	52					4.7796e-09	5.51646e-09	1	0	T	140203530	T	T	140203530	3	4	39	1	0	0	0	0	1	0	0	0	11581	1203	42	4	2172	4	PCDHA5	5	140203530	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	20892	140203530	40711730	155	8171											
PCDHA7	56141	broad.mit.edu	37	chr5	140215375	140215375	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgtgaaggagaacaacccGccgggctgccacatcttcac	10	7	10	14	3	2	2	1	1	1	1	3	3	2	2	3	2	3	1	3	2	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:140215375G>T	uc003lhq.2	+	1	1407	c.1407G>T	c.(1405-1407)CCG>CCT	p.P469P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.P469P	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	469	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding	p.P469P(1)		ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAACAACCCGCCGGGCTGCC	0.682													17	47					9.57634e-11	1.14092e-10	1	0	T	140215375	T	T	140215375	2	4	39	1	0	0	0	0	0	0	0	1	11583	1074	38	3		3	PCDHA7	5	140215375	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	11845	140215375	40699885	156	8172											
PCDHAC2	56134	broad.mit.edu	37	chr5	140389511	140389511	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaacagcacgactgacaacAgtgaccagtgaggtcctcaa	14	5	11	11	1	1	3	1	3	0	0	2	5	2	4	2	2	3	1	2	2	3	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:140389511A>T	uc003lii.2	+	4	3253	c.3013A>T	c.(3013-3015)AGT>TGT	p.S1005C	PCDHA1_uc003lha.2_Missense_Mutation_p.S684C|PCDHA1_uc003lhb.2_Missense_Mutation_p.S948C|PCDHA2_uc003lhd.2_Missense_Mutation_p.S946C|PCDHA3_uc003lhf.2_Missense_Mutation_p.S948C|PCDHA4_uc003lhi.2_Missense_Mutation_p.S945C|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Missense_Mutation_p.S934C|PCDHA6_uc003lhn.2_Missense_Mutation_p.S684C|PCDHA6_uc003lho.2_Missense_Mutation_p.S948C|PCDHA7_uc003lhq.2_Missense_Mutation_p.S935C|PCDHA8_uc003lhs.2_Missense_Mutation_p.S948C|PCDHA9_uc003lhu.2_Missense_Mutation_p.S948C|PCDHA10_uc003lhw.2_Missense_Mutation_p.S683C|PCDHA10_uc003lhx.2_Missense_Mutation_p.S946C|PCDHA11_uc003lia.2_Missense_Mutation_p.S947C|PCDHA12_uc003lic.2_Missense_Mutation_p.S939C|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Missense_Mutation_p.S948C|PCDHAC1_uc003lih.2_Missense_Mutation_p.S961C	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	1005	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACTGACAACAGTGACCAGTG	0.363													32	81					0	0	0	0	T	140389511	T	T	140389511	3	4	39	1	0	0	0	0	1	0	0	0	11587	188	7	5	3115	5	PCDHAC2	5	140389511	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	174136	140389511	40525749	157	8173											
PCDHB6	56130	broad.mit.edu	37	chr5	140531310	140531310	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cacctactcgctgctgccgcCccaggacccgcacctgcccc	5	5	8	23	3	0	0	0	0	0	0	1	1	0	1	8	1	4	3	8	1	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:140531310C>A	uc003lir.2	+	1	1472	c.1472C>A	c.(1471-1473)CCC>CAC	p.P491H	PCDHB6_uc011dah.1_Missense_Mutation_p.P355H	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	491	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGCTGCCGCCCCAGGACCCG	0.657													17	118					4.35082e-09	5.05315e-09	1	0	A	140531310	A	A	140531310	3	1	39	1	0	0	0	0	1	0	0	0	11600	623	22	4	1474	4	PCDHB6	5	140531310	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	141799	140531310	40383950	158	8174											
PCDHB12	56124	broad.mit.edu	37	chr5	140589727	140589727	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacagagagagcagagccgaGtacaacatcaccatcaccgt	15	4	10	12	2	2	3	2	0	0	3	2	6	2	3	3	0	4	2	3	0	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:140589727G>A	uc003liz.2	+	1	1437	c.1248G>A	c.(1246-1248)GAG>GAA	p.E416E	PCDHB12_uc011dak.1_Silent_p.E79E	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	416	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGAGCCGAGTACAACATCA	0.522													18	60					0	0	0	0	A	140589727	A	A	140589727	2	1	39	1	0	0	0	0	0	0	0	1	11591	1020	36	4		4	PCDHB12	5	140589727	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	58417	140589727	40325533	159	8175											
PCDHGA1	56114	broad.mit.edu	37	chr5	140711622	140711622	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcttccatcaggactcctaCtctgcctacattcccgaaaa	10	11	5	15	1	3	0	1	0	2	0	6	2	6	1	4	1	3	0	4	1	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:140711622C>A	uc003lji.1	+	1	1371	c.1371C>A	c.(1369-1371)TAC>TAA	p.Y457*	PCDHGA1_uc011dan.1_Nonsense_Mutation_p.Y457*	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	457	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGACTCCTACTCTGCCTACA	0.478													38	103					1.04352e-10	1.24057e-10	1	0	A	140711622	A	A	140711622	4	1	39	1	0	0	0	0	0	1	0	0	11604	576	20	4	1373	4	PCDHGA1	5	140711622	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	121895	140711622	40203638	160	8176											
PCDHGA3	56112	broad.mit.edu	37	chr5	140723908	140723908	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctcagatcccgctgtgtcTggtaaaaattaacattctgg	10	12	9	10	2	3	1	1	0	2	1	4	1	4	1	1	2	1	3	1	2	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:140723908T>A	uc003ljm.1	+	1	308	c.308T>A	c.(307-309)CTG>CAG	p.L103Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.L103Q	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	103	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCTGTGTCTGGTAAAAATT	0.433													19	49					0	0	0	0	A	140723908	A	A	140723908	3	1	39	1	0	0	0	0	1	0	0	0	11609	1580	55	5	310	5	PCDHGA3	5	140723908	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	12286	140723908	40191352	161	8177											
PCDHGB4	8641	broad.mit.edu	37	chr5	140768224	140768224	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttcagaaaacgtgtacccggGgaccacggtgctacaggtga	11	7	13	10	3	1	2	1	1	0	1	1	3	1	3	2	4	4	2	2	4	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:140768224G>T	uc003lkc.1	+	1	773	c.773G>T	c.(772-774)GGG>GTG	p.G258V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.G258V	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	258	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGTACCCGGGGACCACGGTG	0.498													44	150					1.30475e-32	1.91732e-32	1	0	T	140768224	T	T	140768224	3	4	39	1	0	0	0	0	1	0	0	0	11619	1232	43	4	775	4	PCDHGB4	5	140768224	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	44316	140768224	40147036	162	8178											
SH3TC2	79628	broad.mit.edu	37	chr5	148427468	148427468	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcctcattctccagtgccCagagccgcctccgagcagct	6	8	10	17	2	2	1	1	0	1	1	5	2	4	1	6	1	4	2	6	1	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:148427468C>G	uc003lpu.2	-	3	388	c.236G>C	c.(235-237)TGG>TCG	p.W79S	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Missense_Mutation_p.W79S|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_5'UTR|SH3TC2_uc003lpw.1_Missense_Mutation_p.W79S	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	79							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCAGTGCCCAGAGCCGCCT	0.393													40	139					0	0	0	0	G	148427468	G	G	148427468	3	3	39	1	0	0	0	0	1	0	0	0	14327	595	21	4	3690	4	SH3TC2	5	148427468	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	7659244	148427468	32487792	163	8179											
IL12B	3593	broad.mit.edu	37	chr5	158750296	158750296	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggtgaggaccaccatttCtccaggggcatccggatacc	10	7	11	13	1	1	1	0	1	1	0	3	3	2	3	5	5	1	1	5	5	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:158750296C>A	uc003lxr.1	-	3	172	c.130G>T	c.(130-132)GAA>TAA	p.E44*		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	44	Ig-like C2-type.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACCACCATTTCTCCAGGGGCA	0.413													13	35					1.5842e-08	1.80586e-08	1	0	A	158750296	A	A	158750296	4	1	39	1	0	0	0	0	0	1	0	0	7664	922	32	2	876	2	IL12B	5	158750296	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	10322828	158750296	22164964	164	8180											
NSD1	64324	broad.mit.edu	37	chr5	176638275	176638275	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctctaaggttttggtttcaGgaggctccacacacaattca	10	13	8	10	0	3	0	2	0	1	0	5	1	4	1	1	4	0	3	1	4	2	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:176638275G>T	uc003mfr.3	+	5	3013	c.2875G>T	c.(2875-2877)GGA>TGA	p.G959*	NSD1_uc003mft.3_Nonsense_Mutation_p.G690*|NSD1_uc003mfs.1_Nonsense_Mutation_p.G856*|NSD1_uc011dfx.1_Nonsense_Mutation_p.G607*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	959					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TTTGGTTTCAGGAGGCTCCAC	0.512			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			12	39					6.40141e-05	6.81996e-05	1	0	T	176638275	T	T	176638275	4	4	39	1	0	0	0	0	0	1	0	0	10723	1001	35	4	2889	4	NSD1	5	176638275	Nonsense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	17887979	176638275	4276985	165	8181											
NSD1	64324	broad.mit.edu	37	chr5	176707725	176707725	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accccacagtgtgtcctgccGgagggcgctgtcaaaaccag	9	6	12	14	2	1	0	1	0	0	0	2	1	2	1	5	2	2	1	5	2	2	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr5:176707725G>T	uc003mfr.3	+	18	5920	c.5782G>T	c.(5782-5784)GGA>TGA	p.G1928*	NSD1_uc003mft.3_Nonsense_Mutation_p.G1659*|NSD1_uc003mfs.1_Nonsense_Mutation_p.G1825*|NSD1_uc011dfx.1_Nonsense_Mutation_p.G1576*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1928	AWS.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GTGTCCTGCCGGAGGGCGCTG	0.512			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			17	63					3.41278e-10	4.0313e-10	1	0	T	176707725	T	T	176707725	4	4	39	1	0	0	0	0	0	1	0	0	10723	1117	39	3	5848	3	NSD1	5	176707725	Nonsense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	69450	176707725	4207535	166	8182											
HIST1H3B	8358	broad.mit.edu	37	chr6	26032089	26032089	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcaccaggcgctggaacGgcagcttccgaatcagcaac	10	5	11	15	4	1	0	1	0	0	0	3	2	2	1	2	3	4	5	2	3	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:26032089G>C	uc003nfs.1	-	1	200	c.200C>G	c.(199-201)CCG>CGG	p.P67R		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	67					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						GCGCTGGAACGGCAGCTTCCG	0.617													12	138					0	0	0	0	C	26032089	C	C	26032089	3	2	39	1	0	0	0	0	1	0	0	0	7195	1116	39	3	214	3	HIST1H3B	6	26032089	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08		26032089	145082978	167	8183											
BTN3A3	10384	broad.mit.edu	37	chr6	26451920	26451920	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcggatgtgattctggatCcagacacggcaaacgccatc	11	7	11	12	3	1	2	0	1	1	1	3	4	2	4	2	3	2	1	2	3	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:26451920C>A	uc003nhz.2	+	11	1216	c.1036C>A	c.(1036-1038)CCA>ACA	p.P346T	BTN3A3_uc003nia.2_Missense_Mutation_p.P304T|BTN3A3_uc011dkn.1_Missense_Mutation_p.P297T	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	346	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane					0						GATTCTGGATCCAGACACGGC	0.552													24	43					2.89027e-11	3.45088e-11	1	0	A	26451920	A	A	26451920	3	1	39	1	0	0	0	0	1	0	0	0	1569	855	30	2	1070	2	BTN3A3	6	26451920	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	419831	26451920	144663147	168	8184											
ZNF192	7745	broad.mit.edu	37	chr6	28120855	28120855	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtgagaccaggagtgagaAcagggaattagcttcaaaac	15	7	13	6	0	1	2	1	2	0	2	1	6	1	4	1	3	3	1	1	3	5	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:28120855A>G	uc003nkn.1	+	6	981	c.797A>G	c.(796-798)AAC>AGC	p.N266S	ZNF192_uc010jqx.1_Missense_Mutation_p.N266S|ZNF192_uc010jqy.1_Missense_Mutation_p.N79S|ZNF192_uc011dkz.1_Missense_Mutation_p.N79S	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	266	KRAB.				viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGGAGTGAGAACAGGGAATTA	0.418													17	112					0	0	0	0	G	28120855	G	G	28120855	3	3	39	1	0	0	0	0	1	0	0	0	17823	43	2	5	815	5	ZNF192	6	28120855	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	1668935	28120855	142994212	169	8185											
SCAND3	114821	broad.mit.edu	37	chr6	28547174	28547174	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttccatagaaacttccTgcccatatgtgccctgtgag	8	14	7	12	0	1	2	0	1	1	1	3	2	3	2	4	0	3	0	4	0	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:28547174T>G	uc003nlo.2	-	2	1061	c.443A>C	c.(442-444)CAG>CCG	p.Q148P		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	148					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGAAACTTCCTGCCCATATGT	0.408													20	136					0	0	0	0	G	28547174	G	G	28547174	3	3	39	1	0	0	0	0	1	0	0	0	13941	1580	55	5	3546	5	SCAND3	6	28547174	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	426319	28547174	142567893	170	8186											
OR14J1	442191	broad.mit.edu	37	chr6	29275361	29275361	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgattccatgaaggcagcaCtgaggaagatgctgtcaaag	14	8	12	7	0	1	4	1	3	0	1	2	5	2	5	1	2	2	3	1	2	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:29275361C>A	uc011dln.1	+	1	895	c.895C>A	c.(895-897)CTG>ATG	p.L299M		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAAGGCAGCACTGAGGAAGAT	0.303													83	97					4.00405e-42	6.16179e-42	1	0	A	29275361	A	A	29275361	3	1	39	1	0	0	0	0	1	0	0	0	11002	564	20	4	897	4	OR14J1	6	29275361	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	728187	29275361	141839706	171	8187											
OR10C1	442194	broad.mit.edu	37	chr6	29408401	29408401	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagattatcctggcaacagcCctcctcatcctctgcccctt	7	11	5	18	0	2	1	1	0	1	1	5	1	5	1	6	1	3	1	6	1	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:29408401C>A	uc011dlp.1	+	1	609	c.609C>A	c.(607-609)GCC>GCA	p.A203A	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGGCAACAGCCCTCCTCATCC	0.577													121	238					2.75219e-45	4.25898e-45	1	0	A	29408401	A	A	29408401	2	1	39	1	0	0	0	0	0	0	0	1	10952	610	22	4		4	OR10C1	6	29408401	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	133040	29408401	141706666	172	8188											
TAP2	6891	broad.mit.edu	37	chr6	32805816	32805816	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccagacagagcgggagcagCagtgtccccacaaatcccag	12	3	12	14	1	0	2	0	0	0	2	2	3	2	3	4	1	3	2	4	1	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:32805816C>G	uc003occ.2	-	1	226	c.195G>C	c.(193-195)CTG>CTC	p.L65L	TAP2_uc011dqf.1_Silent_p.L65L|TAP2_uc003ocb.1_Silent_p.L65L|TAP2_uc003ocd.2_Silent_p.L65L	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	65	Helical; Name=2; (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						GCGGGAGCAGCAGTGTCCCCA	0.672													24	98					0	0	0	0	G	32805816	G	G	32805816	2	3	39	1	0	0	0	0	0	0	0	1	15617	697	25	4		4	TAP2	6	32805816	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3397415	32805816	138309251	173	8189											
PIM1	5292	broad.mit.edu	37	chr6	37138806	37138806	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttccgactggggagagcTggtgagtgccctgcaggagc	7	8	17	9	1	0	2	0	1	0	1	1	6	1	3	2	4	4	2	2	4	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:37138806T>C	uc003onk.2	+	3	669	c.239T>C	c.(238-240)CTG>CCG	p.L80P	PIM1_uc011dtw.1_5'Flank	NM_002648	NP_002639	P11309	PIM1_HUMAN	non-specific serine/threonine protein kinase	171	Protein kinase.				cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	TGGGGAGAGCTGGTGAGTGCC	0.677			T	BCL6	NHL								4	131					0	0	0	0	C	37138806	C	C	37138806	3	2	39	1	0	0	0	0	1	0	0	0	11982	1594	55	5	249	5	PIM1	6	37138806	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	4332990	37138806	133976261	174	8190											
MEP1A	4224	broad.mit.edu	37	chr6	46800982	46800982	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacaggggtctggacagtccGgaatttctcccaagtccttg	8	10	11	12	1	2	0	0	0	2	0	5	2	4	2	3	4	0	0	3	4	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:46800982G>A	uc010jzh.1	+	11	1358	c.1316G>A	c.(1315-1317)CGG>CAG	p.R439Q	MEP1A_uc011dwg.1_Missense_Mutation_p.R161Q|MEP1A_uc011dwh.1_Missense_Mutation_p.R467Q|MEP1A_uc011dwi.1_Missense_Mutation_p.R339Q	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	439	MATH.|Extracellular (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			TGGACAGTCCGGAATTTCTCC	0.512													32	103					0	0	0	0	A	46800982	A	A	46800982	3	1	39	1	0	0	0	0	1	0	0	0	9528	1116	39	1	1358	1	MEP1A	6	46800982	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	9662176	46800982	124314085	175	8191											
PKHD1	5314	broad.mit.edu	37	chr6	51732776	51732776	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagggtttccatagaagcaaGaatgtgacttctgtttttcc	11	14	9	7	0	1	3	0	1	1	2	3	3	3	3	2	1	1	3	2	1	5	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:51732776G>C	uc003pah.1	-	48	7894	c.7618C>G	c.(7618-7620)CTT>GTT	p.L2540V	PKHD1_uc010jzn.1_Missense_Mutation_p.L523V|PKHD1_uc003pai.2_Missense_Mutation_p.L2540V	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2540	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					ATAGAAGCAAGAATGTGACTT	0.438													12	78					0	0	0	0	C	51732776	C	C	51732776	3	2	39	1	0	0	0	0	1	0	0	0	12026	942	33	2	4725	2	PKHD1	6	51732776	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4931794	51732776	119382291	176	8192											
DST	667	broad.mit.edu	37	chr6	56496758	56496758	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgaatctgtctaatcagccGatcttcacagttctctaacc	10	13	5	13	2	6	0	2	0	4	0	8	2	6	0	2	0	2	1	2	0	3	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:56496758G>A	uc003pdf.2	-	28	3815	c.3787C>T	c.(3787-3789)CGG>TGG	p.R1263W	DST_uc003pcz.3_Missense_Mutation_p.R1085W|DST_uc011dxj.1_Missense_Mutation_p.R1114W|DST_uc011dxk.1_Missense_Mutation_p.R1125W|DST_uc003pcy.3_Missense_Mutation_p.R759W|DST_uc003pdb.2_Missense_Mutation_p.R759W|DST_uc003pdc.3_Missense_Mutation_p.R759W|DST_uc003pdd.3_Missense_Mutation_p.R759W	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1085					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTAATCAGCCGATCTTCACAG	0.388													35	103					0	0	0	0	A	56496758	A	A	56496758	3	1	39	1	0	0	0	0	1	0	0	0	4805	1057	37	1	18160	1	DST	6	56496758	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4763982	56496758	114618309	177	8193											
BAI3	577	broad.mit.edu	37	chr6	69646437	69646438	+	Missense_Mutation	DNP	CA	TC	TC																															ctggtgtggaagagtggtccCagtggagcacatgttcggtt																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:69646437_69646438CA>TC	uc003pev.3	+	5	1343_1344	c.895_896CA>TC	c.(895-897)CAG>TCG	p.Q299S	BAI3_uc010kak.2_Missense_Mutation_p.Q299S	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	299	TSP type-1 1.|Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AGAGTGGTCCCAGTGGAGCACA	0.46													19	26					0	0	0	0	TC	69646438	TC	TC	69646437	3	4	39	1	0	0	0	0	1	0	0	0	1302	595	21	4	905	4	BAI3	6	69646437	Missense_Mutation	DNP	CA	TCGA-CN-4727-01A-01D-1434-08	13149679	69646437	101468630	178	8194											
C6orf221	154288	broad.mit.edu	37	chr6	74073333	74073333	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagaaggccgagacccagcGgtcttcaatagaagtccggg	11	6	13	11	3	3	3	2	0	1	3	4	4	4	3	3	3	1	0	3	3	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:74073333G>A	uc003pgt.3	+	3	457	c.404G>A	c.(403-405)CGG>CAG	p.R135Q		NM_001017361	NP_001017361	Q587J8	ECAT1_HUMAN	hypothetical protein LOC154288	135										skin(2)	2						GAGACCCAGCGGTCTTCAATA	0.637													21	85					0	0	0	0	A	74073333	A	A	74073333	3	1	39	1	0	0	0	0	1	0	0	0	2365	1116	39	1	414	1	C6orf221	6	74073333	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4426896	74073333	97041734	179	8195											
LCA5	167691	broad.mit.edu	37	chr6	80201313	80201313	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctaaactcaccaaagtaaGatgtcctggttcttcccatt	11	13	6	11	0	2	1	1	0	1	1	4	1	4	1	3	1	2	3	3	1	4	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:80201313G>A	uc003pix.2	-	6	1525	c.1090C>T	c.(1090-1092)CTT>TTT	p.L364F	LCA5_uc003piy.2_Missense_Mutation_p.L364F|LCA5_uc011dyq.1_RNA	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	364					protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		ACCAAAGTAAGATGTCCTGGT	0.343													40	197					0	0	0	0	A	80201313	A	A	80201313	3	1	39	1	0	0	0	0	1	0	0	0	8696	942	33	2	1015	2	LCA5	6	80201313	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	6127980	80201313	90913754	180	8196											
MDN1	23195	broad.mit.edu	37	chr6	90472244	90472244	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taagcttatggtccaccggtTtataactgaaacagacacag	14	10	8	9	1	0	2	0	1	0	1	1	2	1	2	2	2	3	2	2	2	5	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:90472244T>G	uc003pnn.1	-	16	2266	c.2150A>C	c.(2149-2151)AAA>ACA	p.K717T	MDN1_uc003pno.1_Missense_Mutation_p.K135T	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	717					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTCCACCGGTTTATAACTGAA	0.408													17	72					0	0	0	0	G	90472244	G	G	90472244	3	3	39	1	0	0	0	0	1	0	0	0	9468	1841	64	5	14988	5	MDN1	6	90472244	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	10270931	90472244	80642823	181	8197											
FHL5	9457	broad.mit.edu	37	chr6	97051592	97051592	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtgttacatgttatgatCgtgtattttctaactattgc	9	19	7	6	1	1	1	0	1	1	0	2	1	1	1	0	0	3	3	0	0	5	8	rs138154376		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:97051592C>A	uc003pos.1	+	3	508	c.103C>A	c.(103-105)CGT>AGT	p.R35S	FHL5_uc003pot.1_Missense_Mutation_p.R35S	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	35						nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		ATGTTATGATCGTGTATTTTC	0.368													47	100					3.05275e-18	4.09497e-18	1	0	A	97051592	A	A	97051592	3	1	39	1	0	0	0	0	1	0	0	0	5913	884	31	3	105	3	FHL5	6	97051592	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	6579348	97051592	74063475	182	8198											
FHL5	9457	broad.mit.edu	37	chr6	97053872	97053872	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagggacaaagcctttgatCtccaaagagagtggcaatta	15	9	10	7	0	1	2	0	1	1	1	2	4	1	3	2	2	1	1	2	2	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:97053872C>A	uc003pos.1	+	5	834	c.429C>A	c.(427-429)ATC>ATA	p.I143I	FHL5_uc003pot.1_Silent_p.I143I	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	143	LIM zinc-binding 2.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		AGCCTTTGATCTCCAAAGAGA	0.413													34	72					3.11337e-16	4.02054e-16	1	0	A	97053872	A	A	97053872	2	1	39	1	0	0	0	0	0	0	0	1	5913	903	32	2		2	FHL5	6	97053872	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2280	97053872	74061195	183	8199											
KLHL32	114792	broad.mit.edu	37	chr6	97562024	97562024	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactggagtgagctggctccCatgcctgtgggaaggagcca	9	7	15	10	0	0	1	0	1	0	0	1	4	1	4	3	4	4	2	3	4	2	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:97562024C>A	uc010kcm.1	+	7	1465	c.993C>A	c.(991-993)CCC>CCA	p.P331P	KLHL32_uc003poy.2_Silent_p.P331P|KLHL32_uc011ead.1_Silent_p.P295P|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Silent_p.P262P|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	331	Kelch 1.			P -> S (in Ref. 1; BAB70899).						ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		AGCTGGCTCCCATGCCTGTGG	0.567													23	89					1.66031e-10	1.9654e-10	1	0	A	97562024	A	A	97562024	2	1	39	1	0	0	0	0	0	0	0	1	8425	581	21	4		4	KLHL32	6	97562024	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	508152	97562024	73553043	184	8200											
AIM1	202	broad.mit.edu	37	chr6	106987308	106987308	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgaagaacctggatttcaGggtgttcctttcatcctgga	9	14	10	8	0	2	2	2	1	0	1	4	4	4	4	3	3	1	1	3	3	3	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:106987308G>A	uc003prh.2	+	7	4012	c.3525G>A	c.(3523-3525)CAG>CAA	p.Q1175Q	AIM1_uc003pri.2_5'Flank	NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1175	Beta/gamma crystallin 'Greek key' 4.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CTGGATTTCAGGGTGTTCCTT	0.453													41	188					0	0	0	0	A	106987308	A	A	106987308	2	1	39	1	0	0	0	0	0	0	0	1	430	991	35	4		4	AIM1	6	106987308	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	9425284	106987308	64127759	185	8201											
LAMA4	3910	broad.mit.edu	37	chr6	112469437	112469437	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attctgtgaccagttggttaGattgttggccatgggggcag	7	13	15	6	0	1	2	0	1	1	1	1	2	1	2	2	4	0	4	2	4	1	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:112469437G>T	uc003pvu.2	-	18	2584	c.2275C>A	c.(2275-2277)CTA>ATA	p.L759I	LAMA4_uc003pvv.2_Missense_Mutation_p.L752I|LAMA4_uc003pvt.2_Missense_Mutation_p.L752I	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	759	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CAGTTGGTTAGATTGTTGGCC	0.517													27	108					4.7796e-09	5.51646e-09	1	0	T	112469437	T	T	112469437	3	4	39	1	0	0	0	0	1	0	0	0	8648	933	33	2	3284	2	LAMA4	6	112469437	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	5482129	112469437	58645630	186	8202											
C6orf174	387104	broad.mit.edu	37	chr6	127797032	127797032	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgaccttgccgctgagctcGttgatctgcaggcgcgccgc	5	9	13	14	5	1	3	0	3	1	0	2	3	1	3	3	1	3	4	3	1	0	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:127797032G>T	uc003qbd.2	-	6	3004	c.2139C>A	c.(2137-2139)AAC>AAA	p.N713K	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	713	Potential.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CGCTGAGCTCGTTGATCTGCA	0.652													31	139					1.06801e-11	1.29187e-11	1	0	T	127797032	T	T	127797032	3	4	39	1	0	0	0	0	1	0	0	0	2355	1136	40	3	712	3	C6orf174	6	127797032	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	15327595	127797032	43318035	187	8203											
EYA4	2070	broad.mit.edu	37	chr6	133769305	133769305	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgagttgcaacacccccTcttctgcaacaagtatgaga	11	10	8	12	0	2	2	0	2	2	1	2	3	2	2	2	0	5	5	2	0	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:133769305T>A	uc003qec.3	+	5	723	c.265T>A	c.(265-267)TCT>ACT	p.S89T	EYA4_uc011ecq.1_Intron|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Missense_Mutation_p.S89T|EYA4_uc003qee.3_Intron|EYA4_uc011ecs.1_Missense_Mutation_p.S89T|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	89					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CAACACCCCCTCTTCTGCAAC	0.453													21	48					0	0	0	0	A	133769305	A	A	133769305	3	1	39	1	0	0	0	0	1	0	0	0	5356	1551	54	5	279	5	EYA4	6	133769305	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	5972273	133769305	37345762	188	8204											
TBPL1	9519	broad.mit.edu	37	chr6	134305618	134305618	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aacaatagacctcatgccagGtaagtctttgaagcaattta	15	11	7	8	0	2	2	1	1	1	1	2	2	2	2	2	1	3	2	2	1	7	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:134305618G>A	uc010kgg.2	+	5	946	c.386_splice	c.e5+1	p.S129_splice	TBPL1_uc003qel.2_Splice_Site_p.S129_splice	NM_004865	NP_004856	P62380	TBPL1_HUMAN	TBP-like 1						regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	cytoplasm	DNA binding|protein binding|transcription coactivator activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00591)|OV - Ovarian serous cystadenocarcinoma(155;0.00848)		CTCATGCCAGGTAAGTCTTTG	0.318													19	58					0	0	0	0	A	134305618	A	A	134305618	5	1	39	1	0	0	0	0	0	0	1	0	15711	1275	44	4	401	4	TBPL1	6	134305618	Splice_Site	SNP	G	TCGA-CN-4727-01A-01D-1434-08	536313	134305618	36809449	189	8205											
AHI1	54806	broad.mit.edu	37	chr6	135788738	135788738	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catcatcacttgtagtttctTtcatatagtgaagattgctt	10	18	6	7	0	4	2	3	1	1	1	4	2	4	2	0	0	1	3	0	0	4	8			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:135788738T>C	uc003qgi.2	-	6	554	c.170A>G	c.(169-171)AAA>AGA	p.K57R	AHI1_uc003qgh.2_Missense_Mutation_p.K57R|AHI1_uc003qgj.2_Missense_Mutation_p.K57R|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Missense_Mutation_p.K57R	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	57						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TGTAGTTTCTTTCATATAGTG	0.343													11	39					0	0	0	0	C	135788738	C	C	135788738	3	2	39	1	0	0	0	0	1	0	0	0	413	1841	64	5	3573	5	AHI1	6	135788738	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	1483120	135788738	35326329	190	8206											
BCLAF1	9774	broad.mit.edu	37	chr6	136596736	136596736	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagtgcttttgctggcctGtggcaacttaatgtggtcaa	8	14	12	7	0	1	1	1	1	0	0	1	1	1	1	1	3	3	3	1	3	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:136596736G>T	uc003qgx.1	-	6	2039	c.1786C>A	c.(1786-1788)CAG>AAG	p.Q596K	BCLAF1_uc003qgw.1_Missense_Mutation_p.Q423K|BCLAF1_uc003qgy.1_Missense_Mutation_p.Q594K|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.Q594K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	596					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTGCTGGCCTGTGGCAACTTA	0.398													19	289					7.41877e-09	8.50932e-09	1	0	T	136596736	T	T	136596736	3	4	39	1	0	0	0	0	1	0	0	0	1385	1386	48	4	1008	4	BCLAF1	6	136596736	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	807998	136596736	34518331	191	8207											
SHPRH	257218	broad.mit.edu	37	chr6	146244822	146244822	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttgttgcttgtagttgcTggttatttcatttcgcactc	5	20	9	7	1	1	0	1	0	0	0	3	0	1	0	0	1	2	8	0	1	2	8			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:146244822T>A	uc003qlf.2	-	18	3901	c.3502A>T	c.(3502-3504)AGC>TGC	p.S1168C	SHPRH_uc003qld.2_Missense_Mutation_p.S1177C|SHPRH_uc003qle.2_Missense_Mutation_p.S1177C|SHPRH_uc003qlg.1_Missense_Mutation_p.S724C|SHPRH_uc003qlh.2_Missense_Mutation_p.S93C|SHPRH_uc003qli.1_Missense_Mutation_p.S93C	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1168					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TTGTAGTTGCTGGTTATTTCA	0.358													65	114					0	0	0	0	A	146244822	A	A	146244822	3	1	39	1	0	0	0	0	1	0	0	0	14356	1580	55	5	1618	5	SHPRH	6	146244822	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	9648086	146244822	24870245	192	8208											
RAB32	10981	broad.mit.edu	37	chr6	146865142	146865142	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accagcatcatcaagcgctaCgtccaccagctcttctccca	10	8	5	18	2	4	0	2	0	2	0	6	0	5	0	4	0	4	3	4	0	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:146865142C>G	uc003qln.1	+	1	315	c.135C>G	c.(133-135)TAC>TAG	p.Y45*		NM_006834	NP_006825	Q13637	RAB32_HUMAN	RAB32, member RAS oncogene family	45					protein transport|small GTPase mediated signal transduction	mitochondrion	GTP binding				0		Ovarian(120;0.142)		OV - Ovarian serous cystadenocarcinoma(155;2.68e-09)|GBM - Glioblastoma multiforme(68;0.00608)		TCAAGCGCTACGTCCACCAGC	0.557													17	75					0	0	0	0	G	146865142	G	G	146865142	4	3	39	1	0	0	0	0	0	1	0	0	12986	547	19	3	137	3	RAB32	6	146865142	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	620320	146865142	24249925	193	8209											
SYNE1	23345	broad.mit.edu	37	chr6	152640010	152640010	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcttaccttttggtcagtTttagcttgaactacattatc	8	19	5	9	0	2	1	1	1	1	0	3	1	2	1	1	1	4	2	1	1	5	9			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:152640010T>A	uc010kiw.2	-	85	16979	c.16377A>T	c.(16375-16377)AAA>AAT	p.K5459N	SYNE1_uc010kiv.2_5'Flank|SYNE1_uc003qos.3_5'Flank|SYNE1_uc003qot.3_Missense_Mutation_p.K5388N|SYNE1_uc003qou.3_Missense_Mutation_p.K5459N|SYNE1_uc010kiz.2_Missense_Mutation_p.K1214N	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5459	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTGGTCAGTTTTAGCTTGAA	0.363										HNSCC(10;0.0054)			10	50					0	0	0	0	A	152640010	A	A	152640010	3	1	39	1	0	0	0	0	1	0	0	0	15511	1838	64	5	10337	5	SYNE1	6	152640010	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	5774868	152640010	18475057	194	8210											
SYNE1	23345	broad.mit.edu	37	chr6	152702445	152702445	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtttcacttcgggagccagcGactccactctgctgagacgg	7	9	12	13	3	2	1	1	1	1	1	4	4	3	2	2	2	3	2	2	2	0	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:152702445G>C	uc010kiw.2	-	56	9307	c.8705C>G	c.(8704-8706)TCG>TGG	p.S2902W	SYNE1_uc003qot.3_Missense_Mutation_p.S2909W|SYNE1_uc003qou.3_Missense_Mutation_p.S2902W|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_5'UTR|SYNE1_uc010kjb.1_Missense_Mutation_p.S2885W	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2902	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGGAGCCAGCGACTCCACTCT	0.542										HNSCC(10;0.0054)			40	245					0	0	0	0	C	152702445	C	C	152702445	3	2	39	1	0	0	0	0	1	0	0	0	15511	1059	37	3	18125	3	SYNE1	6	152702445	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	62435	152702445	18412622	195	8211											
TIAM2	26230	broad.mit.edu	37	chr6	155578189	155578189	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctagagcgagaattcagtgtCcagagtttaacatctgttgt	11	13	10	7	1	2	3	1	0	1	3	3	4	3	3	1	0	2	2	1	0	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:155578189C>G	uc003qqb.2	+	29	6313	c.5040C>G	c.(5038-5040)GTC>GTG	p.V1680V	TIAM2_uc003qqe.2_Silent_p.V1680V|TIAM2_uc010kjj.2_Silent_p.V1242V|TIAM2_uc003qqf.2_Silent_p.V1056V|TIAM2_uc011efl.1_Silent_p.V1024V|TIAM2_uc003qqg.2_Silent_p.V992V|TIAM2_uc003qqh.2_Silent_p.V605V|uc003qqi.1_5'Flank	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1680					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AATTCAGTGTCCAGAGTTTAA	0.428													15	75					0	0	0	0	G	155578189	G	G	155578189	2	3	39	1	0	0	0	0	0	0	0	1	15957	842	30	2		2	TIAM2	6	155578189	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2875744	155578189	15536878	196	8212											
NOX3	50508	broad.mit.edu	37	chr6	155743931	155743931	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccgcggcaacgcacacaCacactgggtagtgaaataca	13	5	9	14	3	0	1	0	1	0	0	1	1	1	1	2	2	2	3	2	2	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:155743931C>T	uc003qqm.2	-	10	1308	c.1205G>A	c.(1204-1206)TGT>TAT	p.C402Y		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	402	Helical; (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		AACGCACACACACACTGGGTA	0.532													33	196					0	0	0	0	T	155743931	T	T	155743931	3	4	39	1	0	0	0	0	1	0	0	0	10611	478	17	4	517	4	NOX3	6	155743931	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	165742	155743931	15371136	197	8213											
IGF2R	3482	broad.mit.edu	37	chr6	160511018	160511018	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagatccaactttcctccAtcacaagctccagaaacccg	13	8	5	15	1	1	2	1	1	0	2	5	3	5	2	5	0	3	1	5	0	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:160511018A>G	uc003qta.2	+	44	6686	c.6538A>G	c.(6538-6540)ATC>GTC	p.I2180V		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	2180	15.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ACTTTCCTCCATCACAAGCTC	0.512													61	92					0	0	0	0	G	160511018	G	G	160511018	3	3	39	1	0	0	0	0	1	0	0	0	7615	217	8	5	6712	5	IGF2R	6	160511018	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	4767087	160511018	10604049	198	8214											
PARK2	5071	broad.mit.edu	37	chr6	162683695	162683695	+	Frame_Shift_Del	DEL	C	-	-																															ctcccgctcacagcctcccgCcgcgtttctggggtcgtcgc																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:162683695delC	uc003qtx.3	-	3	408	c.274delG	c.(274-276)GCGfs	p.A92fs	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Intron|PARK2_uc003qtw.3_5'UTR|PARK2_uc003qty.3_Frame_Shift_Del_p.A92fs|PARK2_uc003qtz.3_Intron|PARK2_uc010kke.1_Frame_Shift_Del_p.A92fs	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	92			A -> V (in PARK2).		aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CAGCCTCCCGCCGCGTTTCTG	0.582													---	---	---								-	162683695	-	-	162683695	7	5	39	1	0	1	0	1	0	0	0	0	11503	739	26	0	1163	0	PARK2	6	162683695	Frame_Shift_Del	DEL	C	TCGA-CN-4727-01A-01D-1434-08	2172677	162683695	8431372	199	8215											
PDE10A	10846	broad.mit.edu	37	chr6	165749685	165749685	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagcagggaatggccacggCattgtagaacccaagctgcc	12	6	12	11	1	0	1	0	0	0	1	0	2	0	2	3	3	4	4	3	3	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:165749685C>G	uc003qun.2	-	22	2405	c.2164G>C	c.(2164-2166)GCC>CCC	p.A722P	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.A652P|PDE10A_uc003quo.2_Missense_Mutation_p.A732P	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	722					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	ATGGCCACGGCATTGTAGAAC	0.453													9	57					0	0	0	0	G	165749685	G	G	165749685	3	3	39	1	0	0	0	0	1	0	0	0	11684	710	25	4	183	4	PDE10A	6	165749685	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3065990	165749685	5365382	200	8216											
TCP10L2	401285	broad.mit.edu	37	chr6	167585706	167585706	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggacccgtgcccgggagctgGggctgccatggagaagacac	8	4	17	12	2	0	2	0	0	0	2	0	5	0	4	3	5	3	2	3	5	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:167585706G>T	uc010kkp.2	+	2	205	c.74G>T	c.(73-75)GGG>GTG	p.G25V		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	25											0						CCGGGAGCTGGGGCTGCCATG	0.652													13	24					1.02788e-11	1.24606e-11	1	0	T	167585706	T	T	167585706	3	4	39	1	0	0	0	0	1	0	0	0	15778	1232	43	4	76	4	TCP10L2	6	167585706	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1836021	167585706	3529361	201	8217											
C6orf120	387263	broad.mit.edu	37	chr6	170102735	170102735	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tacagctacctgcggctgaaCcacgagggcaagatagtcct	11	7	11	12	2	0	2	0	1	0	1	1	3	1	2	3	2	5	3	3	2	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr6:170102735C>A	uc003qxb.2	+	1	479	c.180C>A	c.(178-180)AAC>AAA	p.N60K	WDR27_uc010kkw.1_5'Flank|WDR27_uc003qwx.2_5'Flank|WDR27_uc003qwy.2_5'Flank|WDR27_uc011egw.1_5'Flank|WDR27_uc010kkx.2_5'Flank|C6orf120_uc011egx.1_Missense_Mutation_p.N79K	NM_001029863	NP_001025034	Q7Z4R8	CF120_HUMAN	hypothetical protein LOC387263 precursor	60						extracellular region					0		Breast(66;0.000338)		OV - Ovarian serous cystadenocarcinoma(33;9.65e-22)|BRCA - Breast invasive adenocarcinoma(81;1.29e-07)|GBM - Glioblastoma multiforme(31;0.0015)		TGCGGCTGAACCACGAGGGCA	0.647													36	60					8.73648e-17	1.13615e-16	1	0	A	170102735	A	A	170102735	3	1	39	1	0	0	0	0	1	0	0	0	2334	506	18	4	182	4	C6orf120	6	170102735	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2517029	170102735	1012332	202	8218											
EIF2AK1	27102	broad.mit.edu	37	chr7	6066485	6066485	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caccttttacggagggattcCggcaactgaccagttcttaa	10	11	9	11	2	1	1	0	1	1	0	2	3	2	3	3	3	2	2	3	3	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:6066485C>A	uc003spp.2	-	14	1784	c.1638G>T	c.(1636-1638)CCG>CCT	p.P546P	EIF2AK1_uc003spq.2_Silent_p.P545P|EIF2AK1_uc011jwm.1_Silent_p.P422P	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	546	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		GGAGGGATTCCGGCAACTGAC	0.498													66	122					2.19297e-23	3.07571e-23	1	0	A	6066485	A	A	6066485	2	1	39	1	0	0	0	0	0	0	0	1	5018	639	23	3		3	EIF2AK1	7	6066485	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08		6066485	153072178	203	8219											
COL28A1	340267	broad.mit.edu	37	chr7	7400084	7400084	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtggtggcctcagatgaggTagtggcaggcagatcatcag	9	8	17	7	0	3	3	3	1	0	2	3	3	3	3	1	6	0	3	1	6	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:7400084T>G	uc003src.1	-	34	3259	c.3142A>C	c.(3142-3144)ACC>CCC	p.T1048P	COL28A1_uc011jxe.1_Missense_Mutation_p.T731P	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	1048					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TCAGATGAGGTAGTGGCAGGC	0.517													50	79					0	0	0	0	G	7400084	G	G	7400084	3	3	39	1	0	0	0	0	1	0	0	0	3701	1638	57	5	243	5	COL28A1	7	7400084	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	1333599	7400084	151738579	204	8220											
HDAC9	9734	broad.mit.edu	37	chr7	18975437	18975437	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgtattatggtaggttttGgtcatttgacgaagcaattg	9	18	11	3	1	1	1	1	1	0	0	1	2	1	1	0	3	1	4	0	3	5	8	rs78483718		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:18975437G>T	uc003suh.2	+	22	2841	c.2800G>T	c.(2800-2802)GGT>TGT	p.G934C	HDAC9_uc003sue.2_Missense_Mutation_p.G934C|HDAC9_uc003sui.2_Missense_Mutation_p.G937C|HDAC9_uc003suj.2_Missense_Mutation_p.G893C|HDAC9_uc003suk.2_Missense_Mutation_p.G182C	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	934	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	GGTAGGTTTTGGTCATTTGAC	0.343													86	155					3.01496e-42	4.65261e-42	1	0	T	18975437	T	T	18975437	3	4	39	1	0	0	0	0	1	0	0	0	7053	1348	47	4	3008	4	HDAC9	7	18975437	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	11575353	18975437	140163226	205	8221											
MACC1	346389	broad.mit.edu	37	chr7	20198323	20198323	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcactgccttcagggttaccCcatagttgctaaagttcaat	10	12	8	11	0	2	0	2	0	0	0	2	0	2	0	3	1	3	5	3	1	5	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:20198323C>A	uc003sus.3	-	5	1970	c.1661G>T	c.(1660-1662)GGG>GTG	p.G554V	MACC1_uc010kug.2_Missense_Mutation_p.G554V	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	554	SH3.				positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						CAGGGTTACCCCATAGTTGCT	0.378													38	248					6.33695e-27	9.04812e-27	1	0	A	20198323	A	A	20198323	3	1	39	1	0	0	0	0	1	0	0	0	9194	623	22	4	909	4	MACC1	7	20198323	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1222886	20198323	138940340	206	8222											
AMPH	273	broad.mit.edu	37	chr7	38431464	38431464	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggtcctggataggcttcTgctccgtagccagctccggt	5	10	14	12	2	1	0	0	0	1	0	4	2	4	1	4	4	3	4	4	4	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:38431464T>A	uc003tgu.2	-	19	1832	c.1763A>T	c.(1762-1764)CAG>CTG	p.Q588L	AMPH_uc003tgv.2_Missense_Mutation_p.Q546L|AMPH_uc003tgt.2_Missense_Mutation_p.Q473L|AMPH_uc003tgw.1_Missense_Mutation_p.Q611L|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	588					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						GATAGGCTTCTGCTCCGTAGC	0.622													24	30					0	0	0	0	A	38431464	A	A	38431464	3	1	39	1	0	0	0	0	1	0	0	0	588	1580	55	5	336	5	AMPH	7	38431464	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	18233141	38431464	120707199	207	8223											
AMPH	273	broad.mit.edu	37	chr7	38530704	38530704	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgttagcaaggacccatcCacgagtttttgatggaagtc	11	11	11	8	1	0	1	0	1	0	0	2	4	1	3	2	2	1	3	2	2	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:38530704C>G	uc003tgu.2	-	5	411	c.342G>C	c.(340-342)GTG>GTC	p.V114V	AMPH_uc003tgv.2_Silent_p.V114V	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	114	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						AGGACCCATCCACGAGTTTTT	0.403													140	211					0	0	0	0	G	38530704	G	G	38530704	2	3	39	1	0	0	0	0	0	0	0	1	588	581	21	4		4	AMPH	7	38530704	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	99240	38530704	120607959	208	8224											
GCK	2645	broad.mit.edu	37	chr7	44184836	44184836	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgaaggtgatctcgcagcTgggcgtcagcctgcgcacgc	7	7	15	12	4	2	2	1	2	1	0	3	3	2	2	1	2	3	3	1	2	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:44184836T>A	uc003tkl.2	-	10	1767	c.1297A>T	c.(1297-1299)AGC>TGC	p.S433C	GCK_uc003tkh.1_Missense_Mutation_p.S106C|GCK_uc003tki.1_Missense_Mutation_p.S111C|GCK_uc003tkj.1_Missense_Mutation_p.S432C|GCK_uc003tkk.1_Missense_Mutation_p.S434C	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	433					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						ATCTCGCAGCTGGGCGTCAGC	0.657													15	25					0	0	0	0	A	44184836	A	A	44184836	3	1	39	1	0	0	0	0	1	0	0	0	6328	1580	55	5	104	5	GCK	7	44184836	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	5654132	44184836	114953827	209	8225											
CAMK2B	816	broad.mit.edu	37	chr7	44259804	44259804	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtactgcgtgagccggaTgtaagcgatgcaggcggcat	10	8	15	8	4	0	1	0	1	0	0	0	3	0	2	1	3	5	4	1	3	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:44259804T>A	uc003tkq.2	-	23	2068	c.1858A>T	c.(1858-1860)ATC>TTC	p.I620F	CAMK2B_uc003tkp.2_Missense_Mutation_p.I496F|CAMK2B_uc003tkx.2_Missense_Mutation_p.I456F|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.I472F|CAMK2B_uc003tks.2_Missense_Mutation_p.I471F|CAMK2B_uc003tku.2_Missense_Mutation_p.I457F|CAMK2B_uc003tkv.2_Missense_Mutation_p.I433F|CAMK2B_uc003tkt.2_Missense_Mutation_p.I446F|CAMK2B_uc003tkw.2_Missense_Mutation_p.I403F|CAMK2B_uc010kyc.2_Missense_Mutation_p.I496F|CAMK2B_uc003tkn.2_Missense_Mutation_p.I253F	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	620					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						GTGAGCCGGATGTAAGCGATG	0.642													9	40					0	0	0	0	A	44259804	A	A	44259804	3	1	39	1	0	0	0	0	1	0	0	0	2612	1464	51	5	146	5	CAMK2B	7	44259804	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	74968	44259804	114878859	210	8226											
H2AFV	94239	broad.mit.edu	37	chr7	44880522	44880522	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtgaggtactccagaatCgcagcactgtacacggcagc	11	6	12	12	2	0	2	0	1	0	1	2	2	1	2	1	2	4	6	1	2	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:44880522C>A	uc003tma.2	-	3	326	c.171G>T	c.(169-171)GCG>GCT	p.A57A	H2AFV_uc003tlz.2_Silent_p.A57A|H2AFV_uc003tmb.2_Intron|H2AFV_uc003tmc.2_Silent_p.A57A|H2AFV_uc003tmd.2_Silent_p.A31A	NM_012412	NP_036544	Q71UI9	H2AV_HUMAN	H2A histone family, member V isoform 1	57					nucleosome assembly	nucleosome|nucleus	DNA binding				0						ACTCCAGAATCGCAGCACTGT	0.512													9	47					7.48243e-07	8.20845e-07	1	0	A	44880522	A	A	44880522	2	1	39	1	0	0	0	0	0	0	0	1	6966	871	31	3		3	H2AFV	7	44880522	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	620718	44880522	114258141	211	8227											
PURB	5814	broad.mit.edu	37	chr7	44924479	44924479	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cggcccggggcccgcgccgaAgccgccaccgccgcggttga	4	2	16	19	9	0	1	0	1	0	0	0	2	0	1	7	4	1	1	7	4	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:44924479A>T	uc003tme.2	-	1	482	c.469T>A	c.(469-471)TTC>ATC	p.F157I		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	157	Gly-rich.|By similarity.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						cccgcgccgAAGCCGCCACCG	0.577													3	6					0	0	0	0	T	44924479	T	T	44924479	3	4	39	1	0	0	0	0	1	0	0	0	12893	72	3	5	473	5	PURB	7	44924479	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	43957	44924479	114214184	212	8228											
PKD1L1	168507	broad.mit.edu	37	chr7	47870817	47870817	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaaactctacagctcacctGtaggctagaaatcctgtccc	13	9	6	13	0	2	1	1	0	1	1	4	1	4	1	3	1	3	3	3	1	6	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:47870817G>C	uc003tny.1	-	42	6471	c.6471C>G	c.(6469-6471)TAC>TAG	p.Y2157*	C7orf69_uc003toa.1_RNA	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2157	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CAGCTCACCTGTAGGCTAGAA	0.507													58	84					0	0	0	0	C	47870817	C	C	47870817	4	2	39	1	0	0	0	0	0	1	0	0	12019	1372	48	4	2142	4	PKD1L1	7	47870817	Nonsense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2946338	47870817	111267846	213	8229											
ABCA13	154664	broad.mit.edu	37	chr7	48356867	48356867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tactatacacaccaaacactCcagaaattaacaaggtcatt	18	9	3	11	0	1	1	1	0	0	1	2	1	2	1	2	1	4	0	2	1	7	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:48356867C>T	uc003toq.2	+	27	9998	c.9973C>T	c.(9973-9975)CCA>TCA	p.P3325S	ABCA13_uc010kys.1_Missense_Mutation_p.P399S|ABCA13_uc003tos.1_Missense_Mutation_p.P151S	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3325					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ACCAAACACTCCAGAAATTAA	0.333													8	50					0	0	0	0	T	48356867	T	T	48356867	3	4	39	1	0	0	0	0	1	0	0	0	31	855	30	2	9908	2	ABCA13	7	48356867	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	486050	48356867	110781796	214	8230											
HIP1	3092	broad.mit.edu	37	chr7	75174442	75174442	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctgagataagtccttctgtCcatcgagagttcttggcata	9	13	10	9	1	2	2	0	1	2	2	5	4	4	2	2	1	0	3	2	1	2	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:75174442C>T	uc003uds.1	-	26	2645	c.2604G>A	c.(2602-2604)TGG>TGA	p.W868*	HIP1_uc011kfz.1_Nonsense_Mutation_p.W694*	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	868	Important for actin binding (By similarity).|I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						GTCCTTCTGTCCATCGAGAGT	0.393			T	PDGFRB	CMML								72	215					0	0	0	0	T	75174442	T	T	75174442	4	4	39	1	0	0	0	0	0	1	0	0	7153	856	30	2	533	2	HIP1	7	75174442	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	26817575	75174442	83964221	215	8231											
PTPN12	5782	broad.mit.edu	37	chr7	77256227	77256227	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acctcaacagaaactatagtAaatcaacagaacttccaggg	18	7	6	10	0	2	2	2	0	0	2	3	2	3	2	2	1	4	1	2	1	8	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:77256227A>C	uc003ugh.2	+	13	1322	c.1231A>C	c.(1231-1233)AAA>CAA	p.K411Q	PTPN12_uc011kgp.1_Missense_Mutation_p.K292Q|PTPN12_uc011kgq.1_Missense_Mutation_p.K281Q|PTPN12_uc010lds.2_Missense_Mutation_p.K143Q	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	411	Interaction with TGFB1I1 (By similarity).					soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						AAACTATAGTAAATCAACAGA	0.368													14	82					0	0	0	0	C	77256227	C	C	77256227	3	2	39	1	0	0	0	0	1	0	0	0	12844	363	13	5	1281	5	PTPN12	7	77256227	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	2081785	77256227	81882436	216	8232											
CACNA2D1	781	broad.mit.edu	37	chr7	81620521	81620521	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtaatctgtgccattgacAggtgtccatgtgtatgtcct	7	15	10	9	0	1	1	0	1	1	0	3	1	3	1	3	1	1	2	3	1	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:81620521A>T	uc003uhr.1	-	21	2032	c.1776T>A	c.(1774-1776)CCT>CCA	p.P592P		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	611	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TGCCATTGACAGGTGTCCATG	0.303													16	105					0	0	0	0	T	81620521	T	T	81620521	2	4	39	1	0	0	0	0	0	0	0	1	2560	175	7	5		5	CACNA2D1	7	81620521	Silent	SNP	A	TCGA-CN-4727-01A-01D-1434-08	4364294	81620521	77518142	217	8233											
CALCR	799	broad.mit.edu	37	chr7	93106955	93106955	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcccagcacagccatccAtcccaggtgcgattgcaata	11	8	7	15	1	1	0	1	0	0	0	4	1	4	0	4	1	4	2	4	1	2	2	rs139631014	byFrequency	TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:93106955A>G	uc003umv.1	-	5	546	c.285T>C	c.(283-285)GAT>GAC	p.D95D	CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Silent_p.D77D|CALCR_uc003umw.2_Silent_p.D77D	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	77	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	ACAGCCATCCATCCCAGGTGC	0.428													29	63					0	0	0	0	G	93106955	G	G	93106955	2	3	39	1	0	0	0	0	0	0	0	1	2591	214	8	5		5	CALCR	7	93106955	Silent	SNP	A	TCGA-CN-4727-01A-01D-1434-08	11486434	93106955	66031708	218	8234											
BET1	10282	broad.mit.edu	37	chr7	93628607	93628607	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaggaggtactccttcacCtgcaaggatcagagtcacaa	12	7	10	12	0	3	1	3	0	0	1	4	3	4	3	3	3	2	2	3	3	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:93628607C>A	uc003unf.1	-	2	182	c.20_splice	c.e2-1	p.G7_splice	BET1_uc003une.3_Splice_Site	NM_005868	NP_005859	O15155	BET1_HUMAN	blocked early in transport 1						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein binding				0	all_cancers(62;2.22e-10)|all_epithelial(64;1.38e-09)|Lung NSC(181;0.218)	Breast(660;0.000162)|Ovarian(593;0.000626)	STAD - Stomach adenocarcinoma(171;0.000967)			ACTCCTTCACCTGCAAGGATC	0.458													33	66					5.8336e-16	7.48106e-16	1	0	A	93628607	A	A	93628607	5	1	39	1	0	0	0	0	0	0	1	0	1410	695	24	4	349	4	BET1	7	93628607	Splice_Site	SNP	C	TCGA-CN-4727-01A-01D-1434-08	521652	93628607	65510056	219	8235											
PPP1R3A	5506	broad.mit.edu	37	chr7	113519481	113519481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtctctgttactagctcCaatccctgccacacttattt	8	14	5	14	0	1	0	0	0	1	0	4	0	3	0	3	1	3	2	3	1	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:113519481C>T	uc010ljy.1	-	4	1697	c.1666G>A	c.(1666-1668)GGA>AGA	p.G556R		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	556					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TTACTAGCTCCAATCCCTGCC	0.418													64	136					0	0	0	0	T	113519481	T	T	113519481	3	4	39	1	0	0	0	0	1	0	0	0	12431	603	21	4	1706	4	PPP1R3A	7	113519481	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	19890874	113519481	45619182	220	8236											
C7orf58	79974	broad.mit.edu	37	chr7	120764512	120764512	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaacatctactctgggacCaaagaccttccataggtaaa	15	9	7	10	0	2	2	0	1	2	1	3	3	3	3	3	2	2	1	3	2	6	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:120764512C>A	uc003vjq.3	+	8	1493	c.1046C>A	c.(1045-1047)CCA>CAA	p.P349Q	C7orf58_uc003vjr.1_Missense_Mutation_p.P349Q|C7orf58_uc003vjs.3_Missense_Mutation_p.P349Q|C7orf58_uc003vjt.3_Missense_Mutation_p.P129Q|C7orf58_uc010lkk.1_Missense_Mutation_p.P129Q	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	349						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					ACTCTGGGACCAAAGACCTTC	0.338													23	79					6.32553e-13	7.85727e-13	1	0	A	120764512	A	A	120764512	3	1	39	1	0	0	0	0	1	0	0	0	2416	594	21	4	1072	4	C7orf58	7	120764512	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	7245031	120764512	38374151	221	8237											
DGKI	9162	broad.mit.edu	37	chr7	137206698	137206698	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccggatcctcagacgatctGggacagactggggactgcaa	10	6	13	12	2	2	2	1	0	1	2	3	6	3	5	2	4	1	1	2	4	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:137206698G>C	uc003vtt.2	-	21	2163	c.2162C>G	c.(2161-2163)CCA>CGA	p.P721R	DGKI_uc003vtu.2_Missense_Mutation_p.P421R	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	721					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CAGACGATCTGGGACAGACTG	0.458													15	46					0	0	0	0	C	137206698	C	C	137206698	3	2	39	1	0	0	0	0	1	0	0	0	4493	1348	47	4	1091	4	DGKI	7	137206698	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	16442186	137206698	21931965	222	8238											
TRPV5	56302	broad.mit.edu	37	chr7	142605970	142605970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attctgatcattgtggttctCaaccctgataaggggaaagg	11	12	11	7	0	3	2	2	2	2	0	4	3	3	3	1	4	1	1	1	4	3	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:142605970C>T	uc003wby.1	-	15	2164	c.1900G>A	c.(1900-1902)GAG>AAG	p.E634K		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	634	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					TTGTGGTTCTCAACCCTGATA	0.502													33	82					0	0	0	0	T	142605970	T	T	142605970	3	4	39	1	0	0	0	0	1	0	0	0	16666	835	29	2	293	2	TRPV5	7	142605970	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	5399272	142605970	16532693	223	8239											
CNTNAP2	26047	broad.mit.edu	37	chr7	147844745	147844745	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccggctaccgcagcagatccGcaaggccccaacagaaggcc	11	2	11	17	3	0	2	0	0	0	2	1	2	1	2	6	3	3	4	6	3	4	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:147844745G>C	uc003weu.1	+	17	3233	c.2717G>C	c.(2716-2718)CGC>CCC	p.R906P		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	906	Laminin G-like 3.|Extracellular (Potential).		R -> H.		behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAGCAGATCCGCAAGGCCCCA	0.557										HNSCC(39;0.1)			35	79					0	0	0	0	C	147844745	C	C	147844745	3	2	39	1	0	0	0	0	1	0	0	0	3662	1087	38	3	2783	3	CNTNAP2	7	147844745	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	5238775	147844745	11293918	224	8240											
DPP6	1804	broad.mit.edu	37	chr7	154519576	154519576	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtgtgatttacaatggcCtcagtgactggctgtatgaa	11	12	12	6	0	1	3	1	3	0	0	1	3	1	3	1	3	1	2	1	3	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:154519576C>T	uc003wlk.2	+	8	991	c.862C>T	c.(862-864)CTC>TTC	p.L288F	DPP6_uc003wli.2_Missense_Mutation_p.L224F|DPP6_uc003wlm.2_Missense_Mutation_p.L226F|DPP6_uc011kvq.1_Missense_Mutation_p.L181F	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	288	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TTACAATGGCCTCAGTGACTG	0.428													26	61					0	0	0	0	T	154519576	T	T	154519576	3	4	39	1	0	0	0	0	1	0	0	0	4752	681	24	4	1008	4	DPP6	7	154519576	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	6674831	154519576	4619087	225	8241											
NCAPG2	54892	broad.mit.edu	37	chr7	158445168	158445168	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgaaacataaaaaaatccCttcactagaaagaaaattgg	22	8	5	6	0	1	3	1	1	0	2	2	3	2	3	1	1	1	0	1	1	10	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr7:158445168C>T	uc003wnv.1	-	23	2896	c.2751G>A	c.(2749-2751)AAG>AAA	p.K917K	NCAPG2_uc010lqu.1_Silent_p.K709K|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Silent_p.K917K|NCAPG2_uc011kwe.1_Silent_p.K917K|NCAPG2_uc011kwc.1_Silent_p.K418K|NCAPG2_uc011kwd.1_Silent_p.K360K	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	917					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		AAAAAAATCCCTTCACTAGAA	0.303													18	53					0	0	0	0	T	158445168	T	T	158445168	2	4	39	1	0	0	0	0	0	0	0	1	10262	680	24	4		4	NCAPG2	7	158445168	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3925592	158445168	693495	226	8242											
RP1L1	94137	broad.mit.edu	37	chr8	10465328	10465328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accttctgattctggctgggCctccccttctgcctcctggg	2	13	10	16	0	3	1	0	1	3	0	5	1	5	1	6	3	1	1	6	3	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:10465328C>T	uc003wtc.2	-	4	6509	c.6280G>A	c.(6280-6282)GCC>ACC	p.A2094T		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2094					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCTGGCTGGGCCTCCCCTTCT	0.627													171	177					0	0	0	0	T	10465328	T	T	10465328	3	4	39	1	0	0	0	0	1	0	0	0	13598	739	26	4	926	4	RP1L1	8	10465328	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08		10465328	135898694	227	8243											
WRN	7486	broad.mit.edu	37	chr8	30958449	30958449	+	Frame_Shift_Del	DEL	C	-	-																															ttcattcaggaagttgggctCcctaaagacagcactgccaa																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:30958449delC	uc003xio.3	+	18	2854	c.2066delC	c.(2065-2067)TCCfs	p.S689fs	WRN_uc010lvk.2_Frame_Shift_Del_p.S156fs	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	689	Helicase ATP-binding.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		AAGTTGGGCTCCCTAAAGACA	0.433			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				---	---	---								-	30958449	-	-	30958449	7	5	39	1	0	1	0	1	0	0	0	0	17470	855	30	0	2132	0	WRN	8	30958449	Frame_Shift_Del	DEL	C	TCGA-CN-4727-01A-01D-1434-08	20493121	30958449	115405573	228	8244											
PCMTD1	115294	broad.mit.edu	37	chr8	52733170	52733170	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttttccttttgggtggaGccctttgaggaatccccttg	4	17	10	10	0	1	1	0	1	1	0	3	3	3	3	4	3	1	0	4	3	1	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:52733170G>C	uc003xqx.3	-	6	1156	c.815C>G	c.(814-816)GCT>GGT	p.A272G	PCMTD1_uc011ldm.1_Missense_Mutation_p.A142G|PCMTD1_uc003xqw.3_Missense_Mutation_p.A272G|PCMTD1_uc011ldn.1_Missense_Mutation_p.A84G|PCMTD1_uc010lya.2_Missense_Mutation_p.A196G	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	272						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				TTTGGGTGGAGCCCTTTGAGG	0.403													37	320					0	0	0	0	C	52733170	C	C	52733170	3	2	39	1	0	0	0	0	1	0	0	0	11640	971	34	4	262	4	PCMTD1	8	52733170	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	21774721	52733170	93630852	229	8245											
ATP6V1H	51606	broad.mit.edu	37	chr8	54669197	54669197	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttggggatcatctgacacttCcaaaagttttgtcaagattc	11	14	8	8	0	3	2	2	1	1	1	5	3	4	3	1	2	0	1	1	2	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:54669197C>A	uc003xrl.2	-	12	1347	c.1195G>T	c.(1195-1197)GAA>TAA	p.E399*	ATP6V1H_uc003xrk.2_Nonsense_Mutation_p.E359*|ATP6V1H_uc003xrm.2_Nonsense_Mutation_p.E399*|ATP6V1H_uc003xrn.2_Nonsense_Mutation_p.E381*|ATP6V1H_uc011ldv.1_Nonsense_Mutation_p.E319*|ATP6V1H_uc010lyd.2_Nonsense_Mutation_p.E335*	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	399					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			TCTGACACTTCCAAAAGTTTT	0.378													9	53					0.000274275	0.000288875	1	0	A	54669197	A	A	54669197	4	1	39	1	0	0	0	0	0	1	0	0	1191	864	30	2	268	2	ATP6V1H	8	54669197	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1936027	54669197	91694825	230	8246											
XKR4	114786	broad.mit.edu	37	chr8	56015496	56015496	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtggttcgggctcacgctcTtcttcgtggtgctcggctct	1	14	14	12	4	4	0	1	0	3	0	7	0	4	0	0	5	1	5	0	5	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:56015496T>C	uc003xsf.2	+	1	480	c.448T>C	c.(448-450)TTC>CTC	p.F150L		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	150	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			GCTCACGCTCTTCTTCGTGGT	0.662													13	59					0	0	0	0	C	56015496	C	C	56015496	3	2	39	1	0	0	0	0	1	0	0	0	17501	1609	56	5	450	5	XKR4	8	56015496	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	1346299	56015496	90348526	231	8247											
CLVS1	157807	broad.mit.edu	37	chr8	62212769	62212769	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctgatcgatgggttccccgGggtgctggaaaaccgagacc	8	8	14	11	3	1	2	0	1	1	1	3	5	2	3	4	4	2	2	4	4	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:62212769G>C	uc003xuh.2	+	2	707	c.383G>C	c.(382-384)GGG>GCG	p.G128A	CLVS1_uc003xug.2_Missense_Mutation_p.G128A|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Missense_Mutation_p.G128A	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	128	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						GGGTTCCCCGGGGTGCTGGAA	0.478													33	56					0	0	0	0	C	62212769	C	C	62212769	3	2	39	1	0	0	0	0	1	0	0	0	3586	1232	43	4	385	4	CLVS1	8	62212769	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	6197273	62212769	84151253	232	8248											
PREX2	80243	broad.mit.edu	37	chr8	69129909	69129909	+	Frame_Shift_Del	DEL	C	-	-																															tggccagaagccacggactgCcacctcgttacatcatgcag																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:69129909delC	uc003xxv.1	+	38	4690	c.4663delC	c.(4663-4665)CCAfs	p.P1555fs		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1555					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CCACGGACTGCCACCTCGTTA	0.552													---	---	---								-	69129909	-	-	69129909	7	5	39	1	0	1	0	1	0	0	0	0	12539	739	26	0	5042	0	PREX2	8	69129909	Frame_Shift_Del	DEL	C	TCGA-CN-4727-01A-01D-1434-08	6917140	69129909	77234113	233	8249											
RUNX1T1	862	broad.mit.edu	37	chr8	93029586	93029586	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattgtggagtgcttctcagTacgatctggaggatgccacc	8	11	12	10	1	2	0	1	0	2	0	3	4	2	3	2	3	3	2	2	3	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:93029586T>A	uc003yfd.2	-	2	178	c.94A>T	c.(94-96)ACT>TCT	p.T32S	RUNX1T1_uc003yfc.1_Missense_Mutation_p.T5S|RUNX1T1_uc003yfe.1_5'UTR|RUNX1T1_uc010mao.2_Missense_Mutation_p.T5S|RUNX1T1_uc011lgi.1_Missense_Mutation_p.T43S|RUNX1T1_uc003yfh.1_5'UTR|RUNX1T1_uc003yfb.1_5'UTR|RUNX1T1_uc003yff.1_5'UTR|RUNX1T1_uc003yfg.1_5'UTR	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	32					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TGCTTCTCAGTACGATCTGGA	0.458													13	92					0	0	0	0	A	93029586	A	A	93029586	3	1	39	1	0	0	0	0	1	0	0	0	13812	1638	57	5	1760	5	RUNX1T1	8	93029586	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	23899677	93029586	53334436	234	8250											
PKHD1L1	93035	broad.mit.edu	37	chr8	110448575	110448575	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcttatgaaggtggtactCtactgactttatctggattt	8	19	8	6	0	3	2	0	2	3	0	3	3	3	3	0	3	2	1	0	3	5	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:110448575C>G	uc003yne.2	+	30	3618	c.3514C>G	c.(3514-3516)CTA>GTA	p.L1172V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1172	Extracellular (Potential).|IPT/TIG 5.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGGTGGTACTCTACTGACTTT	0.308										HNSCC(38;0.096)			10	89					0	0	0	0	G	110448575	G	G	110448575	3	3	39	1	0	0	0	0	1	0	0	0	12027	912	32	2	3632	2	PKHD1L1	8	110448575	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	17418989	110448575	35915447	235	8251											
PKHD1L1	93035	broad.mit.edu	37	chr8	110535590	110535590	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcagctgttgggccaactaCacagaccttactccccttag	10	9	8	14	0	0	1	0	0	0	1	1	1	1	1	4	1	5	3	4	1	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:110535590C>T	uc003yne.2	+	76	12563	c.12459C>T	c.(12457-12459)TAC>TAT	p.Y4153Y		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	4153	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGGCCAACTACACAGACCTTA	0.393										HNSCC(38;0.096)			58	75					0	0	0	0	T	110535590	T	T	110535590	2	4	39	1	0	0	0	0	0	0	0	1	12027	489	17	4		4	PKHD1L1	8	110535590	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	87015	110535590	35828432	236	8252											
CSMD3	114788	broad.mit.edu	37	chr8	113599296	113599296	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatgtctgagttcacctaccTtaagaacatctccttgtgct	9	15	6	11	0	3	2	1	1	2	1	4	2	3	2	3	0	3	2	3	0	4	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:113599296T>A	uc003ynu.2	-	23	4043	c.3884A>T	c.(3883-3885)AAG>ATG	p.K1295M	CSMD3_uc003yns.2_Missense_Mutation_p.K567M|CSMD3_uc003ynt.2_Missense_Mutation_p.K1255M|CSMD3_uc011lhx.1_Missense_Mutation_p.K1191M	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1295	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTCACCTACCTTAAGAACATC	0.249										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			67	57					0	0	0	0	A	113599296	A	A	113599296	3	1	39	1	0	0	0	0	1	0	0	0	3963	1623	56	5	7435	5	CSMD3	8	113599296	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	3063706	113599296	32764726	237	8253											
EIF3H	8667	broad.mit.edu	37	chr8	117658759	117658759	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcggctgtggtggtttgaaGagtttggacaggtcctcctc	5	12	16	8	1	0	2	0	1	0	1	3	3	2	3	2	6	0	3	2	6	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:117658759G>C	uc003yoa.2	-	7	938	c.912C>G	c.(910-912)CTC>CTG	p.L304L	EIF3H_uc003yob.2_Silent_p.L318L	NM_003756	NP_003747	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3,	304					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					GTGGTTTGAAGAGTTTGGACA	0.542													54	357					0	0	0	0	C	117658759	C	C	117658759	2	2	39	1	0	0	0	0	0	0	0	1	5042	929	33	2		2	EIF3H	8	117658759	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4059463	117658759	28705263	238	8254											
SNTB1	6641	broad.mit.edu	37	chr8	121823957	121823957	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcagaaccagggcgtcctCgctcaagttcaccagaactt	10	8	9	14	2	3	2	3	0	0	2	5	2	4	2	3	1	2	3	3	1	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:121823957C>A	uc010mdg.2	-	1	353	c.127G>T	c.(127-129)GAG>TAG	p.E43*	SNTB1_uc003ype.2_Nonsense_Mutation_p.E43*	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	43	PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			AGGGCGTCCTCGCTCAAGTTC	0.607													3	60					0.00024832	0.000262537	1	0	A	121823957	A	A	121823957	4	1	39	1	0	0	0	0	0	1	0	0	14936	893	31	3	1517	3	SNTB1	8	121823957	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4165198	121823957	24540065	239	8255											
TG	7038	broad.mit.edu	37	chr8	134031938	134031938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgttcatccctcagaatGtggtgagttcaaaagcactt	11	13	9	8	0	3	2	3	1	0	1	4	2	4	2	1	1	1	3	1	1	3	3	rs114404536	by1000genomes	TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:134031938G>A	uc003ytw.2	+	39	6915	c.6874G>A	c.(6874-6876)GTG>ATG	p.V2292M	TG_uc010mdw.2_Missense_Mutation_p.V1051M|TG_uc011ljb.1_Missense_Mutation_p.V661M|TG_uc011ljc.1_Missense_Mutation_p.V425M	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2292					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCCTCAGAATGTGGTGAGTTC	0.512													14	96					0	0	0	0	A	134031938	A	A	134031938	3	1	39	1	0	0	0	0	1	0	0	0	15879	1377	48	4	7028	4	TG	8	134031938	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	12207981	134031938	12332084	240	8256											
FAM135B	51059	broad.mit.edu	37	chr8	139158221	139158221	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgattcttttcagacattAggaagtccagttttcctcca	9	15	6	11	0	2	2	1	1	1	1	5	3	5	3	4	1	0	1	4	1	2	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:139158221A>G	uc003yuy.2	-	15	3692	c.3521T>C	c.(3520-3522)CTA>CCA	p.L1174P	FAM135B_uc003yux.2_Missense_Mutation_p.L1075P|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.L736P|FAM135B_uc003yvb.2_Silent_p.P701P	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1174										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTCAGACATTAGGAAGTCCAG	0.433										HNSCC(54;0.14)			42	132					0	0	0	0	G	139158221	G	G	139158221	3	3	39	1	0	0	0	0	1	0	0	0	5477	420	15	5	723	5	FAM135B	8	139158221	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	5126283	139158221	7205801	241	8257											
COL22A1	169044	broad.mit.edu	37	chr8	139833581	139833581	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaacctcggaagaccaccCtgacagcatctttcatggca	12	7	9	13	1	2	3	1	1	1	2	3	5	2	4	3	2	2	2	3	2	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:139833581C>A	uc003yvd.2	-	7	1490	c.1043G>T	c.(1042-1044)AGG>ATG	p.R348M		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	348	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GAAGACCACCCTGACAGCATC	0.572										HNSCC(7;0.00092)			44	240					1.97e-11	2.36742e-11	1	0	A	139833581	A	A	139833581	3	1	39	1	0	0	0	0	1	0	0	0	3696	681	24	4	4073	4	COL22A1	8	139833581	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	675360	139833581	6530441	242	8258											
PUF60	22827	broad.mit.edu	37	chr8	144900183	144900183	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagatgcggttgaaggcccgTgcctcctcagccaactggtc	7	9	12	13	2	1	2	1	1	0	1	3	2	2	2	4	3	4	1	4	3	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:144900183T>G	uc003yzs.2	-	8	730	c.666A>C	c.(664-666)GCA>GCC	p.A222A	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Silent_p.A162A|PUF60_uc003yzt.2_Silent_p.A205A|PUF60_uc003yzq.2_Silent_p.A179A|PUF60_uc003yzu.1_Silent_p.A211A	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	222	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TGAAGGCCCGTGCCTCCTCAG	0.587													5	43					0	0	0	0	G	144900183	G	G	144900183	2	3	39	1	0	0	0	0	0	0	0	1	12889	1683	59	5		5	PUF60	8	144900183	Silent	SNP	T	TCGA-CN-4727-01A-01D-1434-08	5066602	144900183	1463839	243	8259											
PLEC	5339	broad.mit.edu	37	chr8	144994359	144994359	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccttttctgagagcggCagcaggctcagcccggtcag	7	7	14	13	2	3	1	2	1	1	1	3	2	3	1	2	3	4	4	2	3	0	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:144994359C>G	uc003zaf.1	-	32	10211	c.10041G>C	c.(10039-10041)CTG>CTC	p.L3347L	PLEC_uc003zab.1_Silent_p.L3210L|PLEC_uc003zac.1_Silent_p.L3214L|PLEC_uc003zad.2_Silent_p.L3210L|PLEC_uc003zae.1_Silent_p.L3178L|PLEC_uc003zag.1_Silent_p.L3188L|PLEC_uc003zah.2_Silent_p.L3196L|PLEC_uc003zaj.2_Silent_p.L3237L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3347	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTGAGAGCGGCAGCAGGCTCA	0.682													5	45					0	0	0	0	G	144994359	G	G	144994359	2	3	39	1	0	0	0	0	0	0	0	1	12107	697	25	4		4	PLEC	8	144994359	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	94176	144994359	1369663	244	8260											
PARP10	84875	broad.mit.edu	37	chr8	145058522	145058522	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccgggtgctccaggcacaaCacatggcagctaatgctgcc	9	6	11	15	1	0	0	0	0	0	0	1	0	1	0	3	3	5	5	3	3	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:145058522C>A	uc003zal.3	-	6	1644	c.1536G>T	c.(1534-1536)GTG>GTT	p.V512V	PARP10_uc003zak.3_Silent_p.V218V|PARP10_uc011lku.1_Silent_p.V524V|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Silent_p.V512V	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	512						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCAGGCACAACACATGGCAGC	0.637													30	88					2.61193e-14	3.29615e-14	1	0	A	145058522	A	A	145058522	2	1	39	1	0	0	0	0	0	0	0	1	11509	465	17	4		4	PARP10	8	145058522	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	64163	145058522	1305500	245	8261											
RECQL4	9401	broad.mit.edu	37	chr8	145738813	145738813	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtacccgccgccgttccCggctgcacatgcccgcgtgg	3	7	13	18	6	0	0	0	0	0	0	1	0	1	0	5	2	3	5	5	2	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr8:145738813C>A	uc003zdj.2	-	14	2284	c.2252G>T	c.(2251-2253)CGG>CTG	p.R751L		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	751	Helicase C-terminal.				DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CCGCCGTTCCCGGCTGCACAT	0.672			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				16	30					4.96729e-08	5.61608e-08	1	0	A	145738813	A	A	145738813	3	1	39	1	0	0	0	0	1	0	0	0	13267	652	23	3	1407	3	RECQL4	8	145738813	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	680291	145738813	625209	246	8262											
C9orf93	203238	broad.mit.edu	37	chr9	15695323	15695323	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagctttactgtgtcgggcCagtggacatcaggttagttg	8	12	13	8	1	1	0	1	0	0	0	2	1	1	1	1	3	2	3	1	3	2	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:15695323C>A	uc003zmd.2	+	11	1621	c.1306C>A	c.(1306-1308)CAG>AAG	p.Q436K	C9orf93_uc010mih.1_Missense_Mutation_p.Q436K|C9orf93_uc003zme.2_Missense_Mutation_p.Q343K|C9orf93_uc011lmu.1_Missense_Mutation_p.Q436K	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	436											0				GBM - Glioblastoma multiforme(50;4.84e-07)		TGTGTCGGGCCAGTGGACATC	0.413													58	47					6.26901e-30	9.09171e-30	1	0	A	15695323	A	A	15695323	3	1	39	1	0	0	0	0	1	0	0	0	2518	595	21	4	1344	4	C9orf93	9	15695323	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08		15695323	125518108	247	8263											
PGM5	5239	broad.mit.edu	37	chr9	71094402	71094402	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctctccattattgctgccCggaagcagagtgtggaggaa	9	9	14	9	1	1	1	0	0	1	1	2	4	1	4	2	4	3	3	2	4	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:71094402C>T	uc004agr.2	+	8	1457	c.1228C>T	c.(1228-1230)CGG>TGG	p.R410W		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	410					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity	p.R410Q(1)		ovary(1)|pancreas(1)	2						TATTGCTGCCCGGAAGCAGAG	0.527													43	250					0	0	0	0	T	71094402	T	T	71094402	3	4	39	1	0	0	0	0	1	0	0	0	11856	643	23	1	1258	1	PGM5	9	71094402	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	55399079	71094402	70119029	248	8264											
TMEM2	23670	broad.mit.edu	37	chr9	74332976	74332976	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgtggtttttcggggtttgCatcctgatgaggtcgaaatc	7	14	13	7	3	0	2	0	2	0	0	4	3	1	2	1	4	1	3	1	4	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:74332976C>A	uc011lsa.1	-	13	2827	c.2287G>T	c.(2287-2289)GCA>TCA	p.A763S	TMEM2_uc010mos.2_Missense_Mutation_p.A700S|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	763						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TCGGGGTTTGCATCCTGATGA	0.348													100	94					1.07277e-64	1.68839e-64	1	0	A	74332976	A	A	74332976	3	1	39	1	0	0	0	0	1	0	0	0	16187	710	25	4	1912	4	TMEM2	9	74332976	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3238574	74332976	66880455	249	8265											
PRUNE2	158471	broad.mit.edu	37	chr9	79325172	79325172	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaacagattcctgttcactgGaactccacgcatctgcaata	13	10	6	12	1	2	1	1	0	1	1	4	2	4	2	2	1	3	3	2	1	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:79325172G>T	uc010mpk.2	-	8	2142	c.2018C>A	c.(2017-2019)TCC>TAC	p.S673Y		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	673					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CTGTTCACTGGAACTCCACGC	0.493													72	57					2.84776e-26	4.05568e-26	1	0	T	79325172	T	T	79325172	3	4	39	1	0	0	0	0	1	0	0	0	12703	1174	41	2	7296	2	PRUNE2	9	79325172	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4992196	79325172	61888259	250	8266											
FLJ46321	389763	broad.mit.edu	37	chr9	84607717	84607717	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attatcagggatacagccagGagactgtcccaaaagatcac	15	7	9	10	0	2	2	2	0	0	2	3	4	3	3	2	2	2	0	2	2	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:84607717G>T	uc004amn.2	+	4	2379	c.2332G>T	c.(2332-2334)GAG>TAG	p.E778*		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	778						integral to membrane					0						ATACAGCCAGGAGACTGTCCC	0.468													28	156					6.07407e-21	8.24764e-21	1	0	T	84607717	T	T	84607717	4	4	39	1	0	0	0	0	0	1	0	0	5964	1175	41	2	2346	2	FLJ46321	9	84607717	Nonsense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	5282545	84607717	56605714	251	8267											
DAPK1	1612	broad.mit.edu	37	chr9	90317991	90317991	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaaatcatctccacgctGccttcctggaggaagctcaa	12	8	9	12	1	3	1	2	0	1	1	5	4	4	3	3	2	2	2	3	2	4	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:90317991G>T	uc004apc.2	+	25	3057	c.2919G>T	c.(2917-2919)CTG>CTT	p.L973L	DAPK1_uc004apd.2_Silent_p.L973L|DAPK1_uc011ltg.1_Silent_p.L907L|DAPK1_uc011lth.1_Silent_p.L710L	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	973					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						TCTCCACGCTGCCTTCCTGGA	0.597									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				33	127					1.22384e-17	1.61046e-17	1	0	T	90317991	T	T	90317991	2	4	39	1	0	0	0	0	0	0	0	1	4252	1306	46	4		4	DAPK1	9	90317991	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	5710274	90317991	50895440	252	8268											
FAM75C1	441452	broad.mit.edu	37	chr9	90535265	90535265	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacacctgatggagcctcccGgtcctctcatgagcctatgg	8	9	10	14	1	1	2	1	2	1	0	4	3	3	3	5	3	3	0	5	3	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:90535265G>A	uc010mqi.2	+	4	472	c.443G>A	c.(442-444)CGG>CAG	p.R148Q	FAM75C1_uc004apq.3_Missense_Mutation_p.R131Q	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GGAGCCTCCCGGTCCTCTCAT	0.587													179	143					0	0	0	0	A	90535265	A	A	90535265	3	1	39	1	0	0	0	0	1	0	0	0	5655	1116	39	1	457	1	FAM75C1	9	90535265	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	217274	90535265	50678166	253	8269											
FAM75C1	441452	broad.mit.edu	37	chr9	90536403	90536403	+	Frame_Shift_Del	DEL	G	-	-																															ccacatctggggcaaattctGggtgagaccccacaaaatct																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:90536403delG	uc010mqi.2	+	4	1610	c.1581delG	c.(1579-1581)CTGfs	p.L527fs	FAM75C1_uc004apq.3_Frame_Shift_Del_p.L510fs	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GGCAAATTCTGGGTGAGACCC	0.577													---	---	---								-	90536403	-	-	90536403	7	5	39	1	0	1	0	1	0	0	0	0	5655	1335	47	0	1595	0	FAM75C1	9	90536403	Frame_Shift_Del	DEL	G	TCGA-CN-4727-01A-01D-1434-08	1138	90536403	50677028	254	8270											
SHC3	53358	broad.mit.edu	37	chr9	91656972	91656972	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtctttccttgggctgctCtcagcactgctgaccgcagc	5	11	11	14	1	2	1	1	1	2	0	4	1	3	1	2	2	4	5	2	2	0	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:91656972C>A	uc004aqg.2	-	10	1636	c.1329G>T	c.(1327-1329)GAG>GAT	p.E443D		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	443	CH1.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						TTGGGCTGCTCTCAGCACTGC	0.517													26	140					1.08312e-15	1.38579e-15	1	0	A	91656972	A	A	91656972	3	1	39	1	0	0	0	0	1	0	0	0	14337	912	32	2	467	2	SHC3	9	91656972	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1120569	91656972	49556459	255	8271											
ZNF484	83744	broad.mit.edu	37	chr9	95609023	95609023	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccagtatgggattgctgAtgtatatggagacctgactt	9	14	11	7	0	1	3	0	2	1	1	2	5	1	4	2	2	1	3	2	2	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:95609023A>T	uc004asu.1	-	5	2195	c.2046T>A	c.(2044-2046)CAT>CAA	p.H682Q	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Missense_Mutation_p.H684Q|ZNF484_uc010mrb.1_Missense_Mutation_p.H646Q|ZNF484_uc004asv.1_Missense_Mutation_p.H646Q	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	682	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGATTGCTGATGTATATGGA	0.398													155	101					0	0	0	0	T	95609023	T	T	95609023	3	4	39	1	0	0	0	0	1	0	0	0	18004	330	12	5	516	5	ZNF484	9	95609023	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	3952051	95609023	45604408	256	8272											
GALNT12	79695	broad.mit.edu	37	chr9	101608273	101608273	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttagtttttcgagtacacGtcccagaaagaaatacgcta	13	13	7	8	3	0	2	0	0	0	2	2	3	1	2	1	0	2	3	1	0	6	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:101608273G>A	uc004ayz.2	+	9	1473	c.1473G>A	c.(1471-1473)ACG>ACA	p.T491T		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	491	Ricin B-type lectin.|Lumenal (Potential).		T -> M (in CRCS1; germline mutation; loss of activity).			Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				TCGAGTACACGTCCCAGAAAG	0.473													18	54					0	0	0	0	A	101608273	A	A	101608273	2	1	39	1	0	0	0	0	0	0	0	1	6245	1132	40	1		1	GALNT12	9	101608273	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	5999250	101608273	39605158	257	8273											
DBC1	1620	broad.mit.edu	37	chr9	122004402	122004402	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcaacaaagtaggatgatgCgagctggtgcagagcttcaa	13	8	13	7	1	2	2	2	1	0	1	2	4	2	3	0	2	5	4	0	2	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:122004402C>T	uc004bkc.2	-	4	958	c.502G>A	c.(502-504)GCA>ACA	p.A168T	DBC1_uc004bkd.2_Missense_Mutation_p.A168T	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	168	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TAGGATGATGCGAGCTGGTGC	0.512													28	189					0	0	0	0	T	122004402	T	T	122004402	3	4	39	1	0	0	0	0	1	0	0	0	4264	768	27	1	1803	1	DBC1	9	122004402	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	20396129	122004402	19209029	258	8274											
CEL	1056	broad.mit.edu	37	chr9	135947074	135947074	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccccccctgtgccccccacgGgtgactctgaggctgcccct	3	7	10	21	1	1	2	0	2	1	0	1	2	1	2	8	2	2	1	8	2	0	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr9:135947074G>T	uc010naa.1	+	11	2210	c.2194G>T	c.(2194-2196)GGT>TGT	p.G732C		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	729	16.|17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GCCCCCCACGGGTGACTCTGA	0.682													15	82					2.32078e-09	2.70108e-09	1	0	T	135947074	T	T	135947074	3	4	39	1	0	0	0	0	1	0	0	0	3224	1232	43	4	2236	4	CEL	9	135947074	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	13942672	135947074	5266357	259	8275											
DIP2C	22982	broad.mit.edu	37	chr10	394634	394634	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgcgatgttctgtgggtgcgGgggacggacggttattggca	5	10	19	7	5	1	0	0	0	1	0	1	3	1	2	0	6	1	3	0	6	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:394634G>A	uc001ifp.2	-	26	3268	c.3178C>T	c.(3178-3180)CCG>TCG	p.P1060S	DIP2C_uc009xhi.1_Missense_Mutation_p.P446S	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	1060						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		TGTGGGTGCGGGGGACGGACG	0.542													152	165					0	0	0	0	A	394634	A	A	394634	3	1	39	1	0	0	0	0	1	0	0	0	4551	1232	43	4	1540	4	DIP2C	10	394634	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08		394634	135140113	260	8276											
ASB13	79754	broad.mit.edu	37	chr10	5693182	5693182	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgccaactcaccgctcaTgcaggcctcgtgcagggggg	6	7	14	14	2	3	0	2	0	1	0	4	0	3	0	3	4	4	3	3	4	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:5693182T>G	uc001iig.2	-	3	420	c.376A>C	c.(376-378)ATG>CTG	p.M126L	ASB13_uc001iii.2_Intron|ASB13_uc001iih.2_RNA|ASB13_uc009xic.2_Missense_Mutation_p.M126L	NM_024701	NP_078977	Q8WXK3	ASB13_HUMAN	ankyrin repeat and SOCS box-containing protein	126	ANK 4.				intracellular signal transduction		protein binding			ovary(1)	1				GBM - Glioblastoma multiforme(2;9.59e-09)		TCACCGCTCATGCAGGCCTCG	0.612													31	211					0	0	0	0	G	5693182	G	G	5693182	3	3	39	1	0	0	0	0	1	0	0	0	1019	1464	51	5	476	5	ASB13	10	5693182	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	5298548	5693182	129841565	261	8277											
ITIH2	3698	broad.mit.edu	37	chr10	7773950	7773950	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaatagagagcgttatcacGgcgacttcggtacttccact	11	10	9	11	4	1	1	1	0	0	1	3	3	2	1	1	2	2	2	1	2	4	5	rs150260189		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:7773950G>A	uc001ijs.2	+	13	1800	c.1638G>A	c.(1636-1638)ACG>ACA	p.T546T		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	546					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						GCGTTATCACGGCGACTTCGG	0.438													14	148					0	0	0	0	A	7773950	A	A	7773950	2	1	39	1	0	0	0	0	0	0	0	1	7943	1103	39	1		1	ITIH2	10	7773950	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2080768	7773950	127760797	262	8278											
PTER	9317	broad.mit.edu	37	chr10	16526679	16526679	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggctttggtggaaaacaCaaccactgggattagccgag	12	7	14	8	1	0	0	0	0	0	0	0	3	0	2	2	5	3	1	2	5	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:16526679C>A	uc001iog.1	+	3	503	c.296C>A	c.(295-297)ACA>AAA	p.T99K	PTER_uc001ioh.1_Missense_Mutation_p.T99K|PTER_uc001ioi.1_Missense_Mutation_p.T99K|PTER_uc009xjp.1_Missense_Mutation_p.T99K	NM_030664	NP_109589	Q96BW5	PTER_HUMAN	phosphotriesterase related	99					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			ovary(2)	2						GTGGAAAACACAACCACTGGG	0.443													15	104					1.15088e-07	1.29328e-07	1	0	A	16526679	A	A	16526679	3	1	39	1	0	0	0	0	1	0	0	0	12801	478	17	4	298	4	PTER	10	16526679	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	8752729	16526679	119008068	263	8279											
CUBN	8029	broad.mit.edu	37	chr10	16955852	16955852	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacggatgcgtggccagcctCaggttgttaaacattagggt	9	10	14	8	2	1	0	1	0	0	0	1	2	1	1	2	4	3	2	2	4	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:16955852C>A	uc001ioo.2	-	48	7543	c.7491G>T	c.(7489-7491)CTG>CTT	p.L2497L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2497	CUB 18.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGGCCAGCCTCAGGTTGTTAA	0.517													43	261					2.00842e-17	2.63665e-17	1	0	A	16955852	A	A	16955852	2	1	39	1	0	0	0	0	0	0	0	1	4068	813	29	2		2	CUBN	10	16955852	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	429173	16955852	118578895	264	8280											
CUBN	8029	broad.mit.edu	37	chr10	17032445	17032445	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accagatacactccttgtttGgtggatacctgttggggaac	9	12	11	9	0	0	1	0	0	0	1	1	3	1	3	3	4	3	2	3	4	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:17032445G>T	uc001ioo.2	-	29	4290	c.4238C>A	c.(4237-4239)CCA>CAA	p.P1413Q		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1413	CUB 9.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTCCTTGTTTGGTGGATACCT	0.512													24	143					3.6726e-16	4.73168e-16	1	0	T	17032445	T	T	17032445	3	4	39	1	0	0	0	0	1	0	0	0	4068	1348	47	4	6789	4	CUBN	10	17032445	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	76593	17032445	118502302	265	8281											
VIM	7431	broad.mit.edu	37	chr10	17275622	17275622	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctggcacgtcttgaccttGaacgcaaagtggaatctttg	9	12	10	10	2	3	2	0	2	3	0	3	3	3	3	1	2	1	2	1	2	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:17275622G>C	uc001iou.2	+	4	1074	c.661G>C	c.(661-663)GAA>CAA	p.E221Q	VIM_uc001iov.1_Missense_Mutation_p.E221Q|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Missense_Mutation_p.E221Q|VIM_uc001ioy.1_Missense_Mutation_p.E221Q|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Missense_Mutation_p.E221Q|VIM_uc001ipc.1_Missense_Mutation_p.E221Q	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	221	Rod.|Coil 1B.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						TCTTGACCTTGAACGCAAAGT	0.423													60	81					0	0	0	0	C	17275622	C	C	17275622	3	2	39	1	0	0	0	0	1	0	0	0	17234	1291	45	2	671	2	VIM	10	17275622	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	243177	17275622	118259125	266	8282											
SLC39A12	221074	broad.mit.edu	37	chr10	18250541	18250541	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agatgcactattactaatagCtggaggaaattttgaagatc	15	12	9	5	0	0	3	0	1	0	2	1	5	0	5	0	2	3	2	0	2	6	6	rs150700069		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:18250541C>A	uc001ipo.2	+	3	566	c.293C>A	c.(292-294)GCT>GAT	p.A98D	SLC39A12_uc001ipn.2_Missense_Mutation_p.A98D|SLC39A12_uc001ipp.2_Missense_Mutation_p.A98D|SLC39A12_uc010qck.1_Translation_Start_Site	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	98	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TTACTAATAGCTGGAGGAAAT	0.358													89	84					6.31949e-53	9.86196e-53	1	0	A	18250541	A	A	18250541	3	1	39	1	0	0	0	0	1	0	0	0	14679	797	28	4	299	4	SLC39A12	10	18250541	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	974919	18250541	117284206	267	8283											
MKX	283078	broad.mit.edu	37	chr10	28030397	28030397	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gccatgtcttgcagggcctgCcgcttgtgcctcaccttccc	3	11	10	17	1	2	0	1	0	1	0	3	0	3	0	6	1	3	2	6	1	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:28030397C>T	uc001ity.3	-	3	450	c.225G>A	c.(223-225)CGG>CGA	p.R75R	MKX_uc001itx.3_Silent_p.R75R	NM_173576	NP_775847	Q8IYA7	MKX_HUMAN	mohawk homeobox	75	Homeobox; TALE-type.				muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCAGGGCCTGCCGCTTGTGCC	0.662													4	58					0	0	0	0	T	28030397	T	T	28030397	2	4	39	1	0	0	0	0	0	0	0	1	9663	726	26	4		4	MKX	10	28030397	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	9779856	28030397	107504350	268	8284											
SVIL	6840	broad.mit.edu	37	chr10	29762806	29762806	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccagctccaccgtcatcagCgccgacgtgcccttctcact	6	9	7	19	4	3	0	3	0	1	0	6	1	5	0	5	0	3	1	5	0	0	1	rs139597633		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:29762806C>G	uc001iut.1	-	30	6243	c.5490G>C	c.(5488-5490)GCG>GCC	p.A1830A	LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Silent_p.A744A|SVIL_uc001iuu.1_Silent_p.A1404A	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1830	Gelsolin-like 3.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CCGTCATCAGCGCCGACGTGC	0.647													24	80					0	0	0	0	G	29762806	G	G	29762806	2	3	39	1	0	0	0	0	0	0	0	1	15487	755	27	3		3	SVIL	10	29762806	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1732409	29762806	105771941	269	8285											
MAPK8	5599	broad.mit.edu	37	chr10	49632604	49632604	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggagaaatgatcaaaggtGgtgttttgttcccaggtaca	11	12	13	5	0	1	2	1	1	0	1	2	3	2	2	1	4	1	3	1	4	3	4	rs139339988		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:49632604G>T	uc009xnz.2	+	7	888	c.664G>T	c.(664-666)GGT>TGT	p.G222C	MAPK8_uc001jgl.2_Missense_Mutation_p.G222C|MAPK8_uc001jgm.2_Missense_Mutation_p.G222C|MAPK8_uc001jgo.2_Missense_Mutation_p.G222C|MAPK8_uc009xoa.2_Intron|MAPK8_uc001jgn.2_Missense_Mutation_p.G222C|MAPK8_uc010qgk.1_Missense_Mutation_p.G222C|MAPK8_uc001jgp.2_Intron|MAPK8_uc001jgq.2_Intron	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	222	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		GATCAAAGGTGGTGTTTTGTT	0.343													73	103					9.0989e-53	1.41595e-52	1	0	T	49632604	T	T	49632604	3	4	39	1	0	0	0	0	1	0	0	0	9336	1348	47	4	762	4	MAPK8	10	49632604	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	19869798	49632604	85902143	270	8286											
RTKN2	219790	broad.mit.edu	37	chr10	63964747	63964747	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaattatggattcttttcTtggcatccttatccattgcc	9	17	6	9	0	2	1	0	0	2	1	4	2	4	2	3	2	1	1	3	2	3	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:63964747T>C	uc001jlw.2	-	10	1152	c.1055A>G	c.(1054-1056)AAG>AGG	p.K352R	RTKN2_uc009xpf.1_Missense_Mutation_p.K154R|RTKN2_uc001jlv.2_Missense_Mutation_p.K6R	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	352	PH.				signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					GATTCTTTTCTTGGCATCCTT	0.348													30	77					0	0	0	0	C	63964747	C	C	63964747	3	2	39	1	0	0	0	0	1	0	0	0	13788	1609	56	5	786	5	RTKN2	10	63964747	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	14332143	63964747	71570000	271	8287											
JMJD1C	221037	broad.mit.edu	37	chr10	64967944	64967944	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtggaagatgttctggtatcTtgcctactaaaccttcactt	9	15	8	9	0	3	1	1	0	2	1	3	2	3	2	2	2	3	2	2	2	5	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:64967944T>A	uc001jmn.2	-	10	3785	c.3485A>T	c.(3484-3486)AAG>ATG	p.K1162M	JMJD1C_uc001jml.2_Missense_Mutation_p.K943M|JMJD1C_uc001jmm.2_Missense_Mutation_p.K874M|JMJD1C_uc010qiq.1_Missense_Mutation_p.K980M|JMJD1C_uc009xpi.2_Missense_Mutation_p.K980M|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.K199M	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1162					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTCTGGTATCTTGCCTACTAA	0.393													83	147					0	0	0	0	A	64967944	A	A	64967944	3	1	39	1	0	0	0	0	1	0	0	0	7989	1609	56	5	4205	5	JMJD1C	10	64967944	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	1003197	64967944	70566803	272	8288											
LRIT2	340745	broad.mit.edu	37	chr10	85984691	85984691	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctggcaggtgttccagggctCctaggtggatcacactgata	8	10	13	10	0	1	1	1	1	0	0	3	2	3	2	2	5	0	3	2	5	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:85984691C>G	uc001kcy.2	-	2	298	c.290G>C	c.(289-291)GGA>GCA	p.G97A	LRIT2_uc010qmc.1_Missense_Mutation_p.G97A	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	97	LRR 1.					integral to membrane				ovary(2)	2						TTCCAGGGCTCCTAGGTGGAT	0.517													58	168					0	0	0	0	G	85984691	G	G	85984691	3	3	39	1	0	0	0	0	1	0	0	0	8998	855	30	2	1370	2	LRIT2	10	85984691	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	21016747	85984691	49550056	273	8289											
RGR	5995	broad.mit.edu	37	chr10	86014184	86014184	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggagcagaaactggggaaGagtggccatctccaggtaag	13	6	15	7	0	1	2	0	0	1	2	2	4	1	4	2	5	2	2	2	5	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:86014184G>T	uc001kdc.1	+	5	653	c.615G>T	c.(613-615)AAG>AAT	p.K205N	RGR_uc001kdd.1_Missense_Mutation_p.K209N|RGR_uc001kde.1_Missense_Mutation_p.K205N	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	205	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						AACTGGGGAAGAGTGGCCATC	0.363													18	77					2.35188e-11	2.82022e-11	1	0	T	86014184	T	T	86014184	3	4	39	1	0	0	0	0	1	0	0	0	13356	933	33	2	645	2	RGR	10	86014184	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	29493	86014184	49520563	274	8290											
CYP2C18	1562	broad.mit.edu	37	chr10	96495160	96495160	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattgccaatgcatttggtCgtgtgccacccttgtaccag	7	12	9	13	1	0	0	0	0	0	0	1	0	0	0	5	1	4	2	5	1	2	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:96495160C>A	uc001kjv.3	+	9	1758	c.1432C>A	c.(1432-1434)CGT>AGT	p.R478S	CYP2C18_uc001kjw.3_Missense_Mutation_p.R419S|CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Intron	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	478					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding	p.R478L(1)		ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		TGCATTTGGTCGTGTGCCACC	0.478													41	155					1.32136e-16	1.71436e-16	1	0	A	96495160	A	A	96495160	3	1	39	1	0	0	0	0	1	0	0	0	4182	884	31	3	1466	3	CYP2C18	10	96495160	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	10480976	96495160	39039587	275	8291											
ZDHHC16	84287	broad.mit.edu	37	chr10	99215802	99215802	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgggtgtggatacaggaagGtaatgtaagacacacagact	14	8	13	6	0	0	2	0	0	0	2	0	4	0	4	0	4	1	2	0	4	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:99215802G>C	uc001knj.2	+	11	1368	c.1019_splice	c.e11+1	p.R340_splice	ZDHHC16_uc001knp.2_Splice_Site_p.R270_splice|ZDHHC16_uc001knk.2_Splice_Site_p.R340_splice|ZDHHC16_uc001knl.2_Splice_Site_p.R324_splice|ZDHHC16_uc001knm.2_Splice_Site_p.R259_splice|ZDHHC16_uc001knn.2_Splice_Site_p.R301_splice|ZDHHC16_uc010qow.1_Splice_Site_p.R322_splice|ZDHHC16_uc009xvq.2_Splice_Site|ZDHHC16_uc001kno.2_Splice_Site_p.R306_splice|ZDHHC16_uc009xvr.2_Splice_Site_p.R331_splice	NM_198046	NP_932163	Q969W1	ZDH16_HUMAN	Abl-philin 2 isoform 1						apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		ATACAGGAAGGTAATGTAAGA	0.438													14	58					0	0	0	0	C	99215802	C	C	99215802	5	2	39	1	0	0	0	0	0	0	1	0	17673	1275	44	4	1054	4	ZDHHC16	10	99215802	Splice_Site	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2720642	99215802	36318945	276	8292											
HPSE2	60495	broad.mit.edu	37	chr10	100219421	100219421	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaatgtccggccggcccgAagggggcggggcttcaattc	7	6	15	13	4	1	0	1	0	0	0	3	1	2	0	4	6	0	1	4	6	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:100219421A>T	uc001kpn.1	-	12	1749	c.1689T>A	c.(1687-1689)CTT>CTA	p.L563L	HPSE2_uc009xwc.1_3'UTR|HPSE2_uc001kpo.1_Silent_p.L495L|HPSE2_uc009xwd.1_Silent_p.L441L	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	563					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GGCCGGCCCGAAGGGGGCGGG	0.557													14	40					0	0	0	0	T	100219421	T	T	100219421	2	4	39	1	0	0	0	0	0	0	0	1	7384	233	9	5		5	HPSE2	10	100219421	Silent	SNP	A	TCGA-CN-4727-01A-01D-1434-08	1003619	100219421	35315326	277	8293											
DNMBP	23268	broad.mit.edu	37	chr10	101658519	101658519	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattcgttgtataggctccTgcaaggcagtgggcatgaaa	10	10	12	9	1	0	1	0	1	0	0	2	1	1	1	2	3	1	6	2	3	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:101658519T>C	uc001kqj.2	-	8	2795	c.2703_splice	c.e8-1	p.K901_splice	DNMBP_uc010qpl.1_5'Flank|DNMBP_uc001kqg.2_Splice_Site_p.K189_splice|DNMBP_uc001kqh.2_Splice_Site_p.K533_splice	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein						intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TATAGGCTCCTGCAAGGCAGT	0.368													42	120					0	0	0	0	C	101658519	C	C	101658519	5	2	39	1	0	0	0	0	0	0	1	0	4696	1594	55	5	2072	5	DNMBP	10	101658519	Splice_Site	SNP	T	TCGA-CN-4727-01A-01D-1434-08	1439098	101658519	33876228	278	8294											
SORCS3	22986	broad.mit.edu	37	chr10	106675638	106675638	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aaagctgaatgacaaagtggGtttgaagactgtcctcagtt	13	11	11	6	0	1	4	1	3	0	1	2	4	2	4	1	1	1	3	1	1	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:106675638G>A	uc001kyi.1	+	3	970	c.743G>A	c.(742-744)GGT>GAT	p.G248D		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	248	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GACAAAGTGGGTTTGAAGACT	0.468													26	73					0	0	0	0	A	106675638	A	A	106675638	3	1	39	1	0	0	0	0	1	0	0	0	14996	1261	44	4	753	4	SORCS3	10	106675638	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	5017119	106675638	28859109	279	8295											
SORCS1	114815	broad.mit.edu	37	chr10	108389039	108389039	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcacacggaaaatgcccacGttctgatagacgtgtttgat	11	11	10	9	3	2	3	1	2	1	1	2	4	2	4	1	1	1	2	1	1	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:108389039G>T	uc001kym.2	-	19	2591	c.2583C>A	c.(2581-2583)AAC>AAA	p.N861K	SORCS1_uc001kyl.2_Missense_Mutation_p.N861K|SORCS1_uc009xxs.2_Missense_Mutation_p.N861K|SORCS1_uc001kyn.1_Missense_Mutation_p.N861K|SORCS1_uc001kyo.2_Missense_Mutation_p.N861K	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	861	Lumenal (Potential).|PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AAATGCCCACGTTCTGATAGA	0.493													28	30					2.48779e-11	2.97676e-11	1	0	T	108389039	T	T	108389039	3	4	39	1	0	0	0	0	1	0	0	0	14994	1136	40	3	1189	3	SORCS1	10	108389039	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1713401	108389039	27145708	280	8296											
ATRNL1	26033	broad.mit.edu	37	chr10	117486770	117486770	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctccagcaactgcttcgaGaacgacagcagatggccagc	11	5	10	15	2	0	2	0	0	0	2	2	4	1	2	3	1	6	3	3	1	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:117486770G>T	uc001lcg.2	+	27	4194	c.3808G>T	c.(3808-3810)GAA>TAA	p.E1270*	ATRNL1_uc010qsm.1_Nonsense_Mutation_p.E399*|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1270	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ACTGCTTCGAGAACGACAGCA	0.438													25	42					2.12542e-12	2.61082e-12	1	0	T	117486770	T	T	117486770	4	4	39	1	0	0	0	0	0	1	0	0	1209	943	33	2	3914	2	ATRNL1	10	117486770	Nonsense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	9097731	117486770	18047977	281	8297											
MKI67	4288	broad.mit.edu	37	chr10	129901414	129901414	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctcctgctgccaattacaTcttctgcgtccagcttccgc	5	13	7	16	2	3	0	0	0	3	0	6	0	5	0	4	0	5	2	4	0	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr10:129901414T>A	uc001lke.2	-	13	8885	c.8690A>T	c.(8689-8691)GAT>GTT	p.D2897V	MKI67_uc001lkf.2_Missense_Mutation_p.D2537V|MKI67_uc009yav.1_Missense_Mutation_p.D2472V|MKI67_uc009yaw.1_Missense_Mutation_p.D2047V	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2897	16 X 122 AA approximate repeats.|16.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GCCAATTACATCTTCTGCGTC	0.557													67	264					0	0	0	0	A	129901414	A	A	129901414	3	1	39	1	0	0	0	0	1	0	0	0	9651	1435	50	5	1092	5	MKI67	10	129901414	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	12414644	129901414	5633333	282	8298											
PKP3	11187	broad.mit.edu	37	chr11	404053	404053	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgtgctcaacaacctggtgGtggccagccccatcgctgcc	6	8	11	16	1	1	0	1	0	0	0	2	0	1	0	5	3	5	2	5	3	2	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:404053G>A	uc001lpc.2	+	11	2264	c.2188G>A	c.(2188-2190)GTG>ATG	p.V730M		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	730	ARM 8.			V -> G (in Ref. 3; BAD97231).	cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAACCTGGTGGTGGCCAGCCC	0.612													35	128					0	0	0	0	A	404053	A	A	404053	3	1	39	1	0	0	0	0	1	0	0	0	12041	1261	44	4	2230	4	PKP3	11	404053	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08		404053	134602463	283	8299											
MUC5B	727897	broad.mit.edu	37	chr11	1271606	1271606	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccaaagccactccctcctCcagtccagggactgcaactg	9	7	7	18	0	0	0	0	0	0	0	5	1	5	1	6	1	3	1	6	1	2	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:1271606C>A	uc009ycr.1	+	51	15041	c.14915C>A	c.(14914-14916)TCC>TAC	p.S4972Y	MUC5B_uc001ltb.2_Missense_Mutation_p.S4502Y	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4499	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACTCCCTCCTCCAGTCCAGGG	0.642													77	119					3.71121e-27	5.31268e-27	1	0	A	1271606	A	A	1271606	3	1	39	1	0	0	0	0	1	0	0	0	10032	855	30	2	13627	2	MUC5B	11	1271606	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	867553	1271606	133734910	284	8300											
ART1	417	broad.mit.edu	37	chr11	3681086	3681086	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacccctgggcttccgcgatGagcatggggtggccctcctg	4	8	14	15	2	0	1	0	1	0	0	2	2	2	1	5	4	1	2	5	4	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:3681086G>A	uc001lye.1	+	3	438	c.337G>A	c.(337-339)GAG>AAG	p.E113K	ART1_uc009yeb.1_Missense_Mutation_p.E113K	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	113					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	CTTCCGCGATGAGCATGGGGT	0.682													14	40					0	0	0	0	A	3681086	A	A	3681086	3	1	39	1	0	0	0	0	1	0	0	0	999	1291	45	2	343	2	ART1	11	3681086	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2409480	3681086	131325430	285	8301											
HBE1	3046	broad.mit.edu	37	chr11	5291131	5291131	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgcaccatgatgccaggcCtgagagcttgctagtgattg	10	10	12	9	0	0	3	0	3	0	1	0	4	0	3	3	1	4	3	3	1	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:5291131C>A	uc001mal.1	-	1	243	c.-10G>T	c.(-12--8)CAGGC>CATGC		HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Translation_Start_Site	NM_005330	NP_005321	P02100	HBE_HUMAN	epsilon globin						blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATGCCAGGCCTGAGAGCTTG	0.542													10	28					7.48243e-07	8.20845e-07	1	0	A	5291131	A	A	5291131	1	1	39	1	0	0	0	0	0	0	0	0	7019	696	24	4		4	HBE1	11	5291131	Translation_Start_Site	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1610045	5291131	129715385	286	8302											
OR52W1	120787	broad.mit.edu	37	chr11	6220867	6220867	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcgtccactgcactacccTgtcctggtcaccaaagcctg	7	8	10	16	1	1	0	1	0	0	0	3	0	3	0	5	2	3	1	5	2	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:6220867T>A	uc010qzz.1	+	1	414	c.414T>A	c.(412-414)CCT>CCA	p.P138P		NM_001005178	NP_001005178	Q6IF63	O52W1_HUMAN	olfactory receptor, family 52, subfamily W,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;2.13e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCACTACCCTGTCCTGGTCA	0.537													13	75					0	0	0	0	A	6220867	A	A	6220867	2	1	39	1	0	0	0	0	0	0	0	1	11186	1567	55	5		5	OR52W1	11	6220867	Silent	SNP	T	TCGA-CN-4727-01A-01D-1434-08	929736	6220867	128785649	287	8303											
DCHS1	8642	broad.mit.edu	37	chr11	6661920	6661920	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagcagccccgtgtgtgCgtcgatggagaagggtccat	7	8	15	11	3	0	1	0	0	0	1	2	3	1	1	3	2	4	2	3	2	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:6661920C>G	uc001mem.1	-	2	1335	c.925G>C	c.(925-927)GCA>CCA	p.A309P		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	309	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCGTGTGTGCGTCGATGGAG	0.607													38	81					0	0	0	0	G	6661920	G	G	6661920	3	3	39	1	0	0	0	0	1	0	0	0	4304	768	27	3	9051	3	DCHS1	11	6661920	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	441053	6661920	128344596	288	8304											
OR2AG2	338755	broad.mit.edu	37	chr11	6789752	6789752	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgccaggatccaggatgtgGccaccatgatccagcagact	11	7	11	12	0	0	2	0	1	0	1	2	4	2	4	5	3	2	1	5	3	0	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:6789752G>T	uc001meq.1	-	1	437	c.437C>A	c.(436-438)GCC>GAC	p.A146D		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCAGGATGTGGCCACCATGAT	0.507													42	58					6.07928e-31	8.86295e-31	1	0	T	6789752	T	T	6789752	3	4	39	1	0	0	0	0	1	0	0	0	11039	1203	42	4	517	4	OR2AG2	11	6789752	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	127832	6789752	128216764	289	8305											
PTH	5741	broad.mit.edu	37	chr11	13513984	13513984	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctttagttaatacattcaCatcagctttgtctgcctctc	9	16	5	11	0	4	0	2	0	2	0	5	0	4	0	1	0	4	3	1	0	3	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:13513984C>T	uc001mlb.2	-	3	431	c.316G>A	c.(316-318)GTG>ATG	p.V106M		NM_000315	NP_000306	P01270	PTHY_HUMAN	parathyroid hormone preproprotein	106					bone resorption|cAMP metabolic process|cell-cell signaling|cellular calcium ion homeostasis|cellular macromolecule biosynthetic process|induction of apoptosis by hormones|positive regulation of cAMP biosynthetic process|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|skeletal system development		hormone activity|peptide hormone receptor binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(625;0.00116)|Epithelial(150;0.0357)|LUSC - Lung squamous cell carcinoma(625;0.0836)		AATACATTCACATCAGCTTTG	0.428													14	81					0	0	0	0	T	13513984	T	T	13513984	3	4	39	1	0	0	0	0	1	0	0	0	12820	478	17	4	35	4	PTH	11	13513984	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	6724232	13513984	121492532	290	8306											
SOX6	55553	broad.mit.edu	37	chr11	16071443	16071443	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttacaggctctgctgtcttGggtcgggatgagagattcag	7	13	14	7	1	3	2	1	1	2	1	4	4	3	3	0	3	2	2	0	3	1	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:16071443G>C	uc001mme.2	-	11	1365	c.1332C>G	c.(1330-1332)CCC>CCG	p.P444P	SOX6_uc001mmd.2_Silent_p.P393P|SOX6_uc001mmf.2_Silent_p.P390P|SOX6_uc001mmg.2_Silent_p.P431P	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	431					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						CTGCTGTCTTGGGTCGGGATG	0.463													156	299					0	0	0	0	C	16071443	C	C	16071443	2	2	39	1	0	0	0	0	0	0	0	1	15019	1335	47	4		4	SOX6	11	16071443	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2557459	16071443	118935073	291	8307											
SLC6A5	9152	broad.mit.edu	37	chr11	20673942	20673942	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaatgctcgcctgttccgtCatctggatcccaattatgtt	7	15	7	12	2	2	0	1	0	1	0	5	1	4	1	3	1	1	3	3	1	3	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:20673942C>T	uc001mqd.2	+	15	2451	c.2178C>T	c.(2176-2178)GTC>GTT	p.V726V	SLC6A5_uc009yic.2_Silent_p.V491V	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	726	Helical; Name=12; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	CCTGTTCCGTCATCTGGATCC	0.473													49	267					0	0	0	0	T	20673942	T	T	20673942	2	4	39	1	0	0	0	0	0	0	0	1	14751	813	29	2		2	SLC6A5	11	20673942	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4602499	20673942	114332574	292	8308											
SLC17A6	57084	broad.mit.edu	37	chr11	22387106	22387106	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttgcaggaagctttggaatGgtctggtacatgttttggct	7	15	13	6	0	1	0	0	0	1	0	1	2	1	2	0	5	3	5	0	5	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:22387106G>T	uc001mqk.2	+	7	1175	c.762G>T	c.(760-762)ATG>ATT	p.M254I		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	254	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						GCTTTGGAATGGTCTGGTACA	0.398													40	130					4.92203e-23	6.85126e-23	1	0	T	22387106	T	T	22387106	3	4	39	1	0	0	0	0	1	0	0	0	14486	1348	47	4	788	4	SLC17A6	11	22387106	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1713164	22387106	112619410	293	8309											
SLC17A6	57084	broad.mit.edu	37	chr11	22397537	22397537	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttctgaaggttttggcaTggaagccacactgctcctgg	7	12	12	10	0	1	1	0	1	1	0	2	2	2	2	2	4	3	4	2	4	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:22397537T>G	uc001mqk.2	+	10	1597	c.1184T>G	c.(1183-1185)ATG>AGG	p.M395R		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	395	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						GGTTTTGGCATGGAAGCCACA	0.393													52	90					0	0	0	0	G	22397537	G	G	22397537	3	3	39	1	0	0	0	0	1	0	0	0	14486	1464	51	5	1222	5	SLC17A6	11	22397537	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	10431	22397537	112608979	294	8310											
DCDC1	341019	broad.mit.edu	37	chr11	31327905	31327905	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgccaattccgggctgaCtgaaattttaaagaagagaa	14	11	9	7	1	1	4	0	2	1	2	2	5	2	4	2	1	1	1	2	1	6	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:31327905C>A	uc001msv.2	-	5	667	c.465G>T	c.(463-465)CAG>CAT	p.Q155H	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	155					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					TCCGGGCTGACTGAAATTTTA	0.333													14	46					1.49906e-05	1.61258e-05	1	0	A	31327905	A	A	31327905	3	1	39	1	0	0	0	0	1	0	0	0	4301	564	20	4	619	4	DCDC1	11	31327905	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	8930368	31327905	103678611	295	8311											
OR5I1	10798	broad.mit.edu	37	chr11	55703542	55703542	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggccaggatgaaggattctGtatctgcaaaagtacagaaa	15	8	11	7	1	2	2	0	1	2	1	2	4	2	4	1	3	2	3	1	3	6	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:55703542G>T	uc010ris.1	-	1	335	c.335C>A	c.(334-336)ACA>AAA	p.T112K		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAAGGATTCTGTATCTGCAAA	0.438													33	26					3.90053e-15	4.95617e-15	1	0	T	55703542	T	T	55703542	3	4	39	1	0	0	0	0	1	0	0	0	11218	1377	48	4	612	4	OR5I1	11	55703542	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	24375637	55703542	79302974	296	8312											
OR5J2	282775	broad.mit.edu	37	chr11	55944458	55944458	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcagtgatggcctatgaccGctatgtggccattgtgagtc	7	12	13	9	1	1	3	1	3	0	0	2	3	1	3	3	2	0	1	3	2	2	3	rs151315491		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:55944458G>T	uc010rjb.1	+	1	365	c.365G>T	c.(364-366)CGC>CTC	p.R122L		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					GCCTATGACCGCTATGTGGCC	0.453													71	68					1.55545e-33	2.2918e-33	1	0	T	55944458	T	T	55944458	3	4	39	1	0	0	0	0	1	0	0	0	11219	1087	38	3	367	3	OR5J2	11	55944458	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	240916	55944458	79062058	297	8313											
OR5T1	390155	broad.mit.edu	37	chr11	56043301	56043301	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctggttgtaccgatcattGgggatttctggcttcacagc	6	13	13	9	1	3	0	2	0	1	0	3	2	3	1	1	5	2	4	1	5	1	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:56043301G>T	uc001nio.1	+	1	187	c.187G>T	c.(187-189)GGG>TGG	p.G63W		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	63	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					ACCGATCATTGGGGATTTCTG	0.363													23	74					1.50039e-11	1.81093e-11	1	0	T	56043301	T	T	56043301	3	4	39	1	0	0	0	0	1	0	0	0	11235	1348	47	4	189	4	OR5T1	11	56043301	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	98843	56043301	78963215	298	8314											
OR5M3	219482	broad.mit.edu	37	chr11	56237387	56237387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgccggcaagtatgatcattGtatattcttttacaaaggtc	11	15	8	7	1	2	1	1	1	1	0	3	1	2	1	1	2	2	3	1	2	6	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:56237387G>A	uc010rjk.1	-	1	587	c.587C>T	c.(586-588)ACA>ATA	p.T196I		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	196	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TATGATCATTGTATATTCTTT	0.408													91	84					0	0	0	0	A	56237387	A	A	56237387	3	1	39	1	0	0	0	0	1	0	0	0	11229	1377	48	4	338	4	OR5M3	11	56237387	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	194086	56237387	78769129	299	8315											
OR10Q1	219960	broad.mit.edu	37	chr11	57995542	57995542	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctcatcctctgaggtgctgGaccgaggacgcaggtacacg	8	7	13	13	3	2	1	1	1	1	0	3	4	3	3	3	4	2	3	3	4	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:57995542G>T	uc010rkd.1	-	1	806	c.806C>A	c.(805-807)TCC>TAC	p.S269Y		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				TGAGGTGCTGGACCGAGGACG	0.602													26	31					4.72057e-08	5.34805e-08	1	0	T	57995542	T	T	57995542	3	4	39	1	0	0	0	0	1	0	0	0	10970	1174	41	2	157	2	OR10Q1	11	57995542	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1758155	57995542	77010974	300	8316											
C11orf48	79081	broad.mit.edu	37	chr11	62437249	62437249	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggattccaccacaatagaCggcagatgggacttttgaga	12	9	11	9	1	0	3	0	1	0	3	1	6	1	5	2	3	0	1	2	3	2	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:62437249C>G	uc001nue.2	-	3	612	c.177G>C	c.(175-177)CCG>CCC	p.P59P	C11orf48_uc001nuf.2_Silent_p.P59P|C11orf48_uc010rmd.1_Silent_p.P59P|C11orf83_uc001nui.3_5'Flank	NM_024099	NP_077004	Q9BQE6	CK048_HUMAN	hypothetical protein LOC79081	85											0						CCACAATAGACGGCAGATGGG	0.537													41	161					0	0	0	0	G	62437249	G	G	62437249	2	3	39	1	0	0	0	0	0	0	0	1	1650	523	19	3		3	C11orf48	11	62437249	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4441707	62437249	72569267	301	8317											
SLC22A6	9356	broad.mit.edu	37	chr11	62751493	62751493	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gactgggccagctggcgtagGgccctgtgagagcacacaag	9	5	16	11	1	0	1	0	1	0	1	0	3	0	1	2	3	2	3	2	3	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:62751493G>A	uc001nwk.2	-	2	703	c.396C>T	c.(394-396)GCC>GCT	p.A132A	SLC22A6_uc001nwl.2_Silent_p.A132A|SLC22A6_uc001nwj.2_Silent_p.A132A|SLC22A6_uc001nwm.2_Silent_p.A132A	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	132	Extracellular (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						GCTGGCGTAGGGCCCTGTGAG	0.617													19	18					0	0	0	0	A	62751493	A	A	62751493	2	1	39	1	0	0	0	0	0	0	0	1	14522	1219	43	4		4	SLC22A6	11	62751493	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	314244	62751493	72255023	302	8318											
SHANK2	22941	broad.mit.edu	37	chr11	70505947	70505947	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccctacctcaatcaagaagtCcccggtccttagtccggctt	8	10	7	16	2	2	1	2	0	0	1	5	1	5	1	6	2	1	1	6	2	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:70505947C>A	uc001oqc.2	-	14	2125	c.2047G>T	c.(2047-2049)GAC>TAC	p.D683Y	SHANK2_uc010rqn.1_Missense_Mutation_p.D95Y|SHANK2_uc001opz.2_Missense_Mutation_p.D95Y|uc009ysn.1_Intron|SHANK2_uc010rqp.1_Missense_Mutation_p.D95Y	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	304	PDZ.				intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ATCAAGAAGTCCCCGGTCCTT	0.587													8	35					7.48243e-07	8.20845e-07	1	0	A	70505947	A	A	70505947	3	1	39	1	0	0	0	0	1	0	0	0	14330	855	30	2	3542	2	SHANK2	11	70505947	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	7754454	70505947	64500569	303	8319											
INPPL1	3636	broad.mit.edu	37	chr11	71942179	71942179	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcagtgggcgaccgcgagtgGctggacctactgcgcggggg	5	6	19	11	5	1	0	1	0	0	0	1	3	1	1	2	5	2	1	2	5	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:71942179G>A	uc001osf.2	+	12	1590	c.1443G>A	c.(1441-1443)TGG>TGA	p.W481*	INPPL1_uc001osg.2_Nonsense_Mutation_p.W239*	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	481					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						ACCGCGAGTGGCTGGACCTAC	0.617													158	263					0	0	0	0	A	71942179	A	A	71942179	4	1	39	1	0	0	0	0	0	1	0	0	7800	1212	42	4	1489	4	INPPL1	11	71942179	Nonsense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1436232	71942179	63064337	304	8320											
DLG2	1740	broad.mit.edu	37	chr11	84996411	84996411	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcataaaattcttggatatcTgtaaagaaaatgtaaggaaa	19	12	7	3	0	3	1	1	0	2	1	3	3	3	3	0	2	0	2	0	2	9	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:84996411T>A	uc001pak.2	-	4	353	c.41_splice	c.e4-1	p.D14_splice		NM_001142699	NP_001136171	Q15700	DLG2_HUMAN	chapsyn-110 isoform 1							cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CTTGGATATCTGTAAAGAAAA	0.313													25	77					0	0	0	0	A	84996411	A	A	84996411	5	1	39	1	0	0	0	0	0	0	1	0	4577	1594	55	5	3193	5	DLG2	11	84996411	Splice_Site	SNP	T	TCGA-CN-4727-01A-01D-1434-08	13054232	84996411	50010105	305	8321											
FAT3	120114	broad.mit.edu	37	chr11	92498219	92498219	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtaggggtggtgtctgtgCagccagctaacacccctctg	6	11	13	11	0	2	0	0	0	2	0	2	0	2	0	3	3	4	3	3	3	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:92498219C>A	uc001pdj.3	+	5	4176	c.4159C>A	c.(4159-4161)CAG>AAG	p.Q1387K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1387	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGTGTCTGTGCAGCCAGCTAA	0.423										TCGA Ovarian(4;0.039)			8	27					0.00307968	0.00320703	1	0	A	92498219	A	A	92498219	3	1	39	1	0	0	0	0	1	0	0	0	5723	711	25	4	4177	4	FAT3	11	92498219	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	7501808	92498219	42508297	306	8322											
IGSF9B	22997	broad.mit.edu	37	chr11	133790286	133790286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcggggggcgctgggacagGgcccctgccgggcgacttgc	3	4	21	13	4	0	0	0	0	0	0	0	2	0	1	3	7	2	1	3	7	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr11:133790286G>A	uc001qgx.3	-	18	3565	c.3334C>T	c.(3334-3336)CCT>TCT	p.P1112S		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1112	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GCTGGGACAGGGCCCCTGCCG	0.682													5	59					0	0	0	0	A	133790286	A	A	133790286	3	1	39	1	0	0	0	0	1	0	0	0	7645	1232	43	4	723	4	IGSF9B	11	133790286	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	41292067	133790286	1216230	307	8323											
CACNA2D4	93589	broad.mit.edu	37	chr12	1995443	1995443	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtccaagatggtggtgatGgtgtgcttggcaatagtcat	8	13	15	5	0	1	2	1	1	0	1	2	2	2	2	1	4	1	2	1	4	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:1995443G>T	uc001qjp.2	-	8	1170	c.939C>A	c.(937-939)ACC>ACA	p.T313T	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Intron	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	313	VWFA.|Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TGGTGGTGATGGTGTGCTTGG	0.473													11	79					7.03913e-09	8.09061e-09	1	0	T	1995443	T	T	1995443	2	4	39	1	0	0	0	0	0	0	0	1	2563	1335	47	4		4	CACNA2D4	12	1995443	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08		1995443	131856452	308	8324											
CHD4	1108	broad.mit.edu	37	chr12	6690915	6690915	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctggctgggacatcttcttGttttcctccacctcagccag	5	13	8	15	0	3	0	1	0	2	0	5	1	5	1	5	2	1	2	5	2	0	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:6690915G>C	uc001qpo.2	-	31	4745	c.4581C>G	c.(4579-4581)AAC>AAG	p.N1527K	CHD4_uc001qpn.2_Missense_Mutation_p.N1520K|CHD4_uc001qpp.2_Missense_Mutation_p.N1552K|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1527					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ACATCTTCTTGTTTTCCTCCA	0.547													54	193					0	0	0	0	C	6690915	C	C	6690915	3	2	39	1	0	0	0	0	1	0	0	0	3342	1368	48	4	1197	4	CHD4	12	6690915	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4695472	6690915	127160980	309	8325											
LRRC23	10233	broad.mit.edu	37	chr12	7016479	7016479	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttgaaaccctcctccccagGgaacagcatccacatggtga	11	7	8	15	0	0	2	0	2	0	0	3	3	3	3	5	2	3	1	5	2	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:7016479G>A	uc001qrt.3	+	5	883	c.491G>A	c.(490-492)GGG>GAG	p.G164E	LRRC23_uc001qrn.1_Missense_Mutation_p.G164E|LRRC23_uc001qrp.2_Missense_Mutation_p.G164E|LRRC23_uc001qrq.2_Missense_Mutation_p.G164E|LRRC23_uc001qrr.2_Missense_Mutation_p.G113E|LRRC23_uc001qrs.2_Missense_Mutation_p.G113E|LRRC23_uc009zfh.2_Intron	NM_001135217	NP_001128689	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23 isoform a	164	LRR 4.									ovary(1)	1						TCCTCCCCAGGGAACAGCATC	0.547													118	187					0	0	0	0	A	7016479	A	A	7016479	3	1	39	1	0	0	0	0	1	0	0	0	9028	1246	43	4	505	4	LRRC23	12	7016479	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	325564	7016479	126835416	310	8326											
PDE3A	5139	broad.mit.edu	37	chr12	20769239	20769239	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaccaccacctcggccacaGgtctacccaccttggagcct	8	6	7	20	1	1	0	0	0	1	0	2	1	1	1	8	3	2	0	8	3	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:20769239G>T	uc001reh.1	+	4	1367	c.1345G>T	c.(1345-1347)GGT>TGT	p.G449C		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	449					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTCGGCCACAGGTCTACCCAC	0.562													73	102					5.02462e-34	7.46285e-34	1	0	T	20769239	T	T	20769239	3	4	39	1	0	0	0	0	1	0	0	0	11691	1000	35	4	1359	4	PDE3A	12	20769239	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	13752760	20769239	113082656	311	8327											
SLCO1B1	10599	broad.mit.edu	37	chr12	21375295	21375295	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcaatggttatacgagcaCtaggtatgatgaaaaaaaaa	19	9	8	5	1	1	2	1	2	0	0	1	3	1	2	0	2	2	3	0	2	9	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:21375295C>T	uc001req.3	+	13	1848	c.1744C>T	c.(1744-1746)CTA>TTA	p.L582L		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	582	Helical; Name=11; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TATACGAGCACTAGGTATGAT	0.204													22	69					0	0	0	0	T	21375295	T	T	21375295	2	4	39	1	0	0	0	0	0	0	0	1	14787	564	20	4		4	SLCO1B1	12	21375295	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	606056	21375295	112476600	312	8328											
MCRS1	10445	broad.mit.edu	37	chr12	49952509	49952509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagacgaatcgcaggctggCgatctgggtgggagacaaag	12	5	17	7	3	1	2	0	0	1	2	2	6	1	2	0	4	0	2	0	4	3	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:49952509C>T	uc001ruk.1	-	15	1497	c.1306G>A	c.(1306-1308)GCC>ACC	p.A436T	MCRS1_uc001rui.1_Missense_Mutation_p.A449T|MCRS1_uc001ruj.1_Missense_Mutation_p.A423T|MCRS1_uc001rul.1_Missense_Mutation_p.A436T|MCRS1_uc009zlj.1_Missense_Mutation_p.A245T|MCRS1_uc001rum.1_Missense_Mutation_p.A423T	NM_006337	NP_006328	Q96EZ8	MCRS1_HUMAN	microspherule protein 1 isoform 1	436					DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			large_intestine(1)	1						CGCAGGCTGGCGATCTGGGTG	0.577													41	79					0	0	0	0	T	49952509	T	T	49952509	3	4	39	1	0	0	0	0	1	0	0	0	9452	768	27	1	86	1	MCRS1	12	49952509	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	28577214	49952509	83899386	313	8329											
KRT2	3849	broad.mit.edu	37	chr12	53045402	53045402	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgctcacgctcttgggcCttcacattctggatctctgg	5	14	9	13	1	6	0	2	0	4	0	7	1	6	1	1	3	1	2	1	3	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:53045402C>T	uc001sat.2	-	1	558	c.525G>A	c.(523-525)AAG>AAA	p.K175K		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	175	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		GCTCTTGGGCCTTCACATTCT	0.532													62	156					0	0	0	0	T	53045402	T	T	53045402	2	4	39	1	0	0	0	0	0	0	0	1	8496	680	24	4		4	KRT2	12	53045402	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3092893	53045402	80806493	314	8330											
KIF5A	3798	broad.mit.edu	37	chr12	57974825	57974825	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgagagagttaaggccctGgagggtgcactgaaggaggc	10	6	18	7	0	0	3	0	2	0	1	0	6	0	5	1	5	1	3	1	5	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:57974825G>A	uc001sor.1	+	24	2833	c.2625G>A	c.(2623-2625)CTG>CTA	p.L875L	KIF5A_uc010srr.1_Silent_p.L786L	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	875					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						TTAAGGCCCTGGAGGGTGCAC	0.572													19	49					0	0	0	0	A	57974825	A	A	57974825	2	1	39	1	0	0	0	0	0	0	0	1	8344	1335	47	4		4	KIF5A	12	57974825	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4929423	57974825	75877070	315	8331											
AVPR1A	552	broad.mit.edu	37	chr12	63544528	63544528	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccgagggcttcggcctccCggcttgtgttgccagcgccg	2	8	14	17	5	0	0	0	0	0	0	2	1	1	0	6	3	2	3	6	3	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:63544528C>G	uc001sro.1	-	1	2063	c.89G>C	c.(88-90)CGG>CCG	p.R30P		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	30	Extracellular (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	TTCGGCCTCCCGGCTTGTGTT	0.706													23	91					0	0	0	0	G	63544528	G	G	63544528	3	3	39	1	0	0	0	0	1	0	0	0	1233	652	23	3	1175	3	AVPR1A	12	63544528	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	5569703	63544528	70307367	316	8332											
ZDHHC17	23390	broad.mit.edu	37	chr12	77216208	77216208	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaatcagcgcttgatttggCaaaacagagaaaaaatgtgt	16	9	10	6	2	1	2	1	1	0	1	1	4	1	2	0	1	2	2	0	1	6	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:77216208C>A	uc001syk.1	+	8	957	c.794C>A	c.(793-795)GCA>GAA	p.A265E	ZDHHC17_uc001syi.1_RNA|ZDHHC17_uc001syj.2_RNA	NM_015336	NP_056151	Q8IUH5	ZDH17_HUMAN	huntingtin interacting protein 14	265	Cytoplasmic (Potential).				lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding				0						CTTGATTTGGCAAAACAGAGA	0.363													19	46					1.9806e-07	2.22116e-07	1	0	A	77216208	A	A	77216208	3	1	39	1	0	0	0	0	1	0	0	0	17674	710	25	4	824	4	ZDHHC17	12	77216208	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	13671680	77216208	56635687	317	8333											
NAV3	89795	broad.mit.edu	37	chr12	78444924	78444924	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggactgatgacatcaacaGtgggtaagtaaccctgttct	12	10	10	9	0	2	2	1	2	1	0	2	3	2	3	1	2	2	3	1	2	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:78444924G>C	uc001syp.2	+	11	2686	c.2513G>C	c.(2512-2514)AGT>ACT	p.S838T	NAV3_uc001syo.2_Missense_Mutation_p.S838T|NAV3_uc010sub.1_Missense_Mutation_p.S338T	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	838						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GACATCAACAGTGGGTAAGTA	0.453										HNSCC(70;0.22)			32	66					0	0	0	0	C	78444924	C	C	78444924	3	2	39	1	0	0	0	0	1	0	0	0	10238	1029	36	4	2555	4	NAV3	12	78444924	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1228716	78444924	55406971	318	8334											
ACSS3	79611	broad.mit.edu	37	chr12	81610681	81610681	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataacatttctttttccagaGactggatctccaattactgc	11	15	5	10	0	2	1	0	0	2	1	4	3	3	2	2	1	3	0	2	1	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:81610681G>T	uc001szl.1	+	10	1447	c.1356G>T	c.(1354-1356)GAG>GAT	p.E452D	ACSS3_uc001szm.1_Missense_Mutation_p.E451D|ACSS3_uc001szn.1_Missense_Mutation_p.E134D	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	452						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TTTTTCCAGAGACTGGATCTC	0.408													20	92					8.04996e-18	1.07204e-17	1	0	T	81610681	T	T	81610681	3	4	39	1	0	0	0	0	1	0	0	0	190	956	33	2	1394	2	ACSS3	12	81610681	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	3165757	81610681	52241214	319	8335											
PPFIA2	8499	broad.mit.edu	37	chr12	81839439	81839439	+	Frame_Shift_Del	DEL	C	-	-																															ctgggcttgccgttttaccaCcgtcattcttagtgatcttt																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:81839439delC	uc001szo.1	-	6	627	c.466delG	c.(466-468)GTGfs	p.V156fs	PPFIA2_uc010sue.1_Frame_Shift_Del_p.V56fs|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	82										ovary(3)|lung(2)|pancreas(1)	6						CGTTTTACCACCGTCATTCTT	0.428													---	---	---								-	81839439	-	-	81839439	7	5	39	1	0	1	0	1	0	0	0	0	12365	507	18	0	3415	0	PPFIA2	12	81839439	Frame_Shift_Del	DEL	C	TCGA-CN-4727-01A-01D-1434-08	228758	81839439	52012456	320	8336											
MRPL42	28977	broad.mit.edu	37	chr12	93873224	93873224	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtatgctaccacccttctgtGgacattccatatgaacacac	11	11	6	13	0	1	1	0	1	1	0	2	2	2	2	3	1	3	2	3	1	4	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:93873224G>C	uc001tcr.2	+	4	353	c.195G>C	c.(193-195)GTG>GTC	p.V65V	MRPL42_uc001tcq.2_Silent_p.V65V|MRPL42_uc001tcs.2_Silent_p.V65V|MRPL42_uc001tct.2_RNA	NM_172177	NP_751917	Q9Y6G3	RM42_HUMAN	mitochondrial ribosomal protein L42 isoform a	65					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			ovary(2)	2						ACCCTTCTGTGGACATTCCAT	0.328													33	68					0	0	0	0	C	93873224	C	C	93873224	2	2	39	1	0	0	0	0	0	0	0	1	9859	1335	47	4		4	MRPL42	12	93873224	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	12033785	93873224	39978671	321	8337											
SLC41A2	84102	broad.mit.edu	37	chr12	105260337	105260337	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaaaaatacaccaactaatgGagaaatgtagtaataggtct	19	9	8	5	0	1	1	0	0	1	1	1	3	1	1	1	2	2	2	1	2	9	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:105260337G>T	uc001tla.2	-	6	1215	c.1048C>A	c.(1048-1050)CCA>ACA	p.P350T		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	350	Helical; (Potential).					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CCAACTAATGGAGAAATGTAG	0.343													40	71					4.92203e-23	6.85126e-23	1	0	T	105260337	T	T	105260337	3	4	39	1	0	0	0	0	1	0	0	0	14694	1174	41	2	693	2	SLC41A2	12	105260337	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	11387113	105260337	28591558	322	8338											
BTBD11	121551	broad.mit.edu	37	chr12	108051315	108051315	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcacagagctctcagcataTtgcgaaggctactttctcaa	11	11	8	11	1	3	1	3	0	2	1	5	2	3	1	0	1	4	3	0	1	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:108051315T>A	uc001tmk.1	+	17	3656	c.3135T>A	c.(3133-3135)TAT>TAA	p.Y1045*	BTBD11_uc001tml.1_Nonsense_Mutation_p.Y582*|BTBD11_uc001tmm.1_Nonsense_Mutation_p.Y124*	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	1045						integral to membrane	DNA binding			skin(2)|ovary(1)	3						TCTCAGCATATTGCGAAGGCT	0.463													33	66					0	0	0	0	A	108051315	A	A	108051315	4	1	39	1	0	0	0	0	0	1	0	0	1544	1500	52	5	3306	5	BTBD11	12	108051315	Nonsense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	2790978	108051315	25800580	323	8339											
KSR2	283455	broad.mit.edu	37	chr12	118198938	118198938	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggagggcggtggggtcccCgggggcttcagcttgttctt	3	10	19	9	2	2	0	1	0	1	0	3	2	3	1	2	7	1	3	2	7	0	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:118198938C>T	uc001two.2	-	4	832	c.777G>A	c.(775-777)CCG>CCA	p.P259P		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	288	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTGGGGTCCCCGGGGGCTTCA	0.682													70	425					0	0	0	0	T	118198938	T	T	118198938	2	4	39	1	0	0	0	0	0	0	0	1	8622	639	23	1		1	KSR2	12	118198938	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	10147623	118198938	15652957	324	8340											
ACADS	35	broad.mit.edu	37	chr12	121175737	121175737	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcctggatcaccaatgcctgGgaggcttcggctgccgtggt	5	9	15	12	2	1	0	1	0	0	0	2	2	1	2	4	5	2	2	4	5	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:121175737G>C	uc001tza.3	+	5	688	c.570G>C	c.(568-570)TGG>TGC	p.W190C	ACADS_uc010szl.1_Intron|ACADS_uc001tzb.3_Missense_Mutation_p.W117C	NM_000017	NP_000008	P16219	ACADS_HUMAN	short-chain acyl-CoA dehydrogenase precursor	190						mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(2)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)	CCAATGCCTGGGAGGCTTCGG	0.642													29	82					0	0	0	0	C	121175737	C	C	121175737	3	2	39	1	0	0	0	0	1	0	0	0	114	1241	43	4	588	4	ACADS	12	121175737	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2976799	121175737	12676158	325	8341											
PITPNM2	57605	broad.mit.edu	37	chr12	123494588	123494588	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctcttctgtcttatactcgTtgtggggcacagggtctttg	4	16	11	10	1	4	0	0	0	4	0	5	0	4	0	1	3	1	2	1	3	2	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:123494588T>A	uc001uej.1	-	5	591	c.452A>T	c.(451-453)AAC>ATC	p.N151I	PITPNM2_uc001uek.1_Missense_Mutation_p.N151I|PITPNM2_uc009zxu.1_Missense_Mutation_p.N151I	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	151					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CTTATACTCGTTGTGGGGCAC	0.557													91	197					0	0	0	0	A	123494588	A	A	123494588	3	1	39	1	0	0	0	0	1	0	0	0	12006	1725	60	5	3681	5	PITPNM2	12	123494588	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	2318851	123494588	10357307	326	8342											
TMEM132B	114795	broad.mit.edu	37	chr12	126138491	126138491	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atagagcgcgaaggaaaccaGgagagagcagtccaggaatg	16	3	15	7	2	0	2	0	0	0	2	1	7	1	5	2	3	3	1	2	3	4	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr12:126138491G>A	uc001uhe.1	+	9	2480	c.2472G>A	c.(2470-2472)CAG>CAA	p.Q824Q	TMEM132B_uc001uhf.1_Silent_p.Q336Q	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	824	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AAGGAAACCAGGAGAGAGCAG	0.502													32	111					0	0	0	0	A	126138491	A	A	126138491	2	1	39	1	0	0	0	0	0	0	0	1	16112	991	35	4		4	TMEM132B	12	126138491	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2643903	126138491	7713404	327	8343											
TPTE2	93492	broad.mit.edu	37	chr13	20137831	20137831	+	5'Flank	DEL	T	-	-																															tccgctccaccatcaccatcTtcttcccaattgcaagctag																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:20137831delT	uc010tcm.1	-									Q6XPS3	TPTE2_HUMAN	Homo sapiens mRNA for TPIP alpha lipid phosphatase (TPIP gene).							endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CATCACCATCTTCTTCCCAAT	0.468													---	---	---								-	20137831	-	-	20137831	6	5	39	0	1	1	0	1	0	0	0	0	16498	1624	56	0		0	TPTE2	13	20137831	5'Flank	DEL	T	TCGA-CN-4727-01A-01D-1434-08		20137831	95032047	328	8344											
TNFRSF19	55504	broad.mit.edu	37	chr13	24233278	24233278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccgttatctgcagcgctctgGccaccgtcctgctggccctg	3	10	11	17	3	2	0	0	0	2	0	3	0	3	0	5	2	3	4	5	2	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:24233278G>A	uc001uov.1	+	6	599	c.535G>A	c.(535-537)GCC>ACC	p.A179T	TNFRSF19_uc001uot.2_Missense_Mutation_p.A179T|TNFRSF19_uc010tcu.1_Missense_Mutation_p.A47T|TNFRSF19_uc001uow.2_Missense_Mutation_p.A179T	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	179	Helical; (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		CAGCGCTCTGGCCACCGTCCT	0.552													28	45					0	0	0	0	A	24233278	A	A	24233278	3	1	39	1	0	0	0	0	1	0	0	0	16358	1203	42	4	553	4	TNFRSF19	13	24233278	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4095447	24233278	90936600	329	8345											
ATP12A	479	broad.mit.edu	37	chr13	25262596	25262596	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tatcctcctgtgggtgggcgCctttctctgttggattgcat	3	16	12	10	1	1	0	0	0	1	0	4	1	3	1	3	3	1	2	3	3	1	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:25262596C>T	uc001upp.2	+	4	555	c.368C>T	c.(367-369)GCC>GTC	p.A123V	ATP12A_uc010aaa.2_Missense_Mutation_p.A123V	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	123	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TGGGTGGGCGCCTTTCTCTGT	0.572													241	406					0	0	0	0	T	25262596	T	T	25262596	3	4	39	1	0	0	0	0	1	0	0	0	1124	739	26	4	382	4	ATP12A	13	25262596	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1029318	25262596	89907282	330	8346											
NUPL1	9818	broad.mit.edu	37	chr13	25901160	25901160	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcaagcaaataattcacatAtaacccctcaaggtaacatg	17	9	4	11	0	3	0	3	0	0	0	3	0	3	0	2	1	3	2	2	1	7	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:25901160A>G	uc001uqi.2	+	11	1384	c.1138A>G	c.(1138-1140)ATA>GTA	p.I380V	NUPL1_uc001uqg.1_Missense_Mutation_p.I380V|NUPL1_uc001uqj.2_Missense_Mutation_p.I368V	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	380	14 X 2 AA repeats of F-G.|Potential.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		TAATTCACATATAACCCCTCA	0.363													35	126					0	0	0	0	G	25901160	G	G	25901160	3	3	39	1	0	0	0	0	1	0	0	0	10828	449	16	5	1180	5	NUPL1	13	25901160	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	638564	25901160	89268718	331	8347											
ATP8A2	51761	broad.mit.edu	37	chr13	26413696	26413696	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccttaggttttctggggtCactgcatcaacgccttggtc	5	15	10	11	1	3	0	2	0	1	0	5	0	4	0	2	4	2	2	2	4	2	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:26413696C>T	uc001uqk.2	+	30	3032	c.2890C>T	c.(2890-2892)CAC>TAC	p.H964Y	ATP8A2_uc010tdi.1_Missense_Mutation_p.H899Y|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.H514Y	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	924	Helical; (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TTTCTGGGGTCACTGCATCAA	0.498													26	202					0	0	0	0	T	26413696	T	T	26413696	3	4	39	1	0	0	0	0	1	0	0	0	1195	826	29	2	3008	2	ATP8A2	13	26413696	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	512536	26413696	88756182	332	8348											
KATNAL1	84056	broad.mit.edu	37	chr13	30784522	30784522	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatatcttccagttgaataTcaggatctaattcgacctca	12	14	5	10	1	4	1	2	1	2	0	6	3	5	2	2	1	0	1	2	1	5	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:30784522T>A	uc001uss.2	-	10	1306	c.1205A>T	c.(1204-1206)GAT>GTT	p.D402V	KATNAL1_uc001ust.2_Missense_Mutation_p.D402V	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	402						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		CAGTTGAATATCAGGATCTAA	0.378													22	113					0	0	0	0	A	30784522	A	A	30784522	3	1	39	1	0	0	0	0	1	0	0	0	8024	1435	50	5	275	5	KATNAL1	13	30784522	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	4370826	30784522	84385356	333	8349											
USPL1	10208	broad.mit.edu	37	chr13	31233367	31233367	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatgcctgcgttagaacattAaacttggagagtccgatgaa	14	10	10	7	2	0	3	0	1	0	2	1	5	1	3	2	1	4	1	2	1	6	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:31233367A>G	uc001utc.2	+	9	3585	c.3153A>G	c.(3151-3153)TTA>TTG	p.L1051L	USPL1_uc001utd.2_Silent_p.L722L|USPL1_uc001ute.1_Silent_p.L722L	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	1051					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		TTAGAACATTAAACTTGGAGA	0.398													29	120					0	0	0	0	G	31233367	G	G	31233367	2	3	39	1	0	0	0	0	0	0	0	1	17160	359	13	5		5	USPL1	13	31233367	Silent	SNP	A	TCGA-CN-4727-01A-01D-1434-08	448845	31233367	83936511	334	8350											
PDS5B	23047	broad.mit.edu	37	chr13	33344509	33344509	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaagggtaaaagaggccGaccaccaaaacctcttggtg	17	5	10	9	1	1	1	0	0	1	1	1	2	1	1	4	3	1	1	4	3	7	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:33344509G>T	uc010abf.2	+	32	4033	c.3875G>T	c.(3874-3876)CGA>CTA	p.R1292L	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	1292	A.T hook 2.				cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		AAAAGAGGCCGACCACCAAAA	0.418													9	41					7.48243e-07	8.20845e-07	1	0	T	33344509	T	T	33344509	3	4	39	1	0	0	0	0	1	0	0	0	11746	1058	37	3	3997	3	PDS5B	13	33344509	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2111142	33344509	81825369	335	8351											
NBEA	26960	broad.mit.edu	37	chr13	35733576	35733576	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggagagaatggtgcccttGtggaggttgaatctctgttg	7	13	16	5	0	1	2	0	1	1	1	2	5	1	4	1	4	1	2	1	4	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:35733576G>C	uc001uvb.2	+	23	3474	c.3268G>C	c.(3268-3270)GTG>CTG	p.V1090L	NBEA_uc010abi.2_5'Flank	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1090						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGGTGCCCTTGTGGAGGTTGA	0.383													11	41					0	0	0	0	C	35733576	C	C	35733576	3	2	39	1	0	0	0	0	1	0	0	0	10240	1377	48	4	3354	4	NBEA	13	35733576	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2389067	35733576	79436302	336	8352											
MAB21L1	4081	broad.mit.edu	37	chr13	36049804	36049804	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcggattctcagtttcaCttcgctggtgtctgccacca	6	14	8	13	2	4	0	2	0	3	0	7	1	4	1	2	2	1	2	2	2	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:36049804C>T	uc001uvc.2	-	1	1029	c.472G>A	c.(472-474)GTG>ATG	p.V158M	NBEA_uc001uvb.2_Intron|NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_5'Flank|NBEA_uc010teg.1_5'Flank	NM_005584	NP_005575	Q13394	MB211_HUMAN	mab-21-like protein 1	158					anatomical structure morphogenesis	nucleus				ovary(2)	2		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		CTCAGTTTCACTTCGCTGGTG	0.572													35	56					0	0	0	0	T	36049804	T	T	36049804	3	4	39	1	0	0	0	0	1	0	0	0	9192	565	20	4	611	4	MAB21L1	13	36049804	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	316228	36049804	79120074	337	8353											
DCLK1	9201	broad.mit.edu	37	chr13	36700076	36700076	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaatccctttgaagtatcGatctccgtttcgatagaaac	12	12	6	11	3	1	2	0	1	1	1	5	4	2	2	2	0	1	2	2	0	5	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:36700076G>T	uc001uvf.2	-	2	432	c.199C>A	c.(199-201)CGA>AGA	p.R67R		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	67	Doublecortin 1.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TTGAAGTATCGATCTCCGTTT	0.547													29	124					8.58068e-18	1.13725e-17	1	0	T	36700076	T	T	36700076	2	4	39	1	0	0	0	0	0	0	0	1	4308	1066	37	3		3	DCLK1	13	36700076	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	650272	36700076	78469802	338	8354											
NEK5	341676	broad.mit.edu	37	chr13	52650229	52650229	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatttctgttctggatttttActttcctttgtgttctgaag	5	23	7	6	0	3	1	0	1	3	0	4	2	4	2	1	1	1	2	1	1	3	9			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:52650229A>T	uc001vge.2	-	19	1838	c.1698T>A	c.(1696-1698)AGT>AGA	p.S566R		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	566							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CTGGATTTTTACTTTCCTTTG	0.348													24	42					0	0	0	0	T	52650229	T	T	52650229	3	4	39	1	0	0	0	0	1	0	0	0	10381	388	14	5	444	5	NEK5	13	52650229	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	15950153	52650229	62519649	339	8355											
PCDH17	27253	broad.mit.edu	37	chr13	58208417	58208417	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgctagacgtgaatgacaaCgcgccagtgatcgtgctccc	9	8	12	12	4	0	4	0	3	0	1	2	4	1	4	2	0	3	2	2	0	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:58208417C>T	uc001vhq.1	+	1	2629	c.1737C>T	c.(1735-1737)AAC>AAT	p.N579N	PCDH17_uc010aec.1_Silent_p.N579N	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	579	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGAATGACAACGCGCCAGTGA	0.642													11	69					0	0	0	0	T	58208417	T	T	58208417	2	4	39	1	0	0	0	0	0	0	0	1	11566	535	19	1		1	PCDH17	13	58208417	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	5558188	58208417	56961461	340	8356											
NALCN	259232	broad.mit.edu	37	chr13	101844272	101844272	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgctgaactcaccagaGtggcaaaaagatgatagaga	19	6	10	6	0	1	5	1	2	0	3	1	6	1	5	1	1	2	2	1	1	6	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:101844272G>T	uc001vox.1	-	14	1949	c.1760C>A	c.(1759-1761)ACT>AAT	p.T587N	NALCN_uc001voy.2_Missense_Mutation_p.T302N|NALCN_uc001voz.2_Missense_Mutation_p.T587N|NALCN_uc001vpa.2_Missense_Mutation_p.T587N	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	587	Helical; Name=S6 of repeat II; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACTCACCAGAGTGGCAAAAAG	0.393													19	18					1.55795e-14	1.97055e-14	1	0	T	101844272	T	T	101844272	3	4	39	1	0	0	0	0	1	0	0	0	10201	1029	36	4	3580	4	NALCN	13	101844272	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	43635855	101844272	13325606	341	8357											
FAM155A	728215	broad.mit.edu	37	chr13	107862932	107862932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actcccacccggcactgtacCtgtacagatgaaactggaga	12	7	9	13	1	0	3	0	1	0	2	1	4	1	3	3	2	3	3	3	2	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr13:107862932C>T	uc001vql.2	-	2	1603	c.1087G>A	c.(1087-1089)GGG>AGG	p.G363R		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	363						integral to membrane	binding			skin(1)	1						GGCACTGTACCTGTACAGATG	0.458													29	51					0	0	0	0	T	107862932	T	T	107862932	3	4	39	1	0	0	0	0	1	0	0	0	5493	695	24	4	297	4	FAM155A	13	107862932	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	6018660	107862932	7306946	342	8358											
OR4M1	441670	broad.mit.edu	37	chr14	20248711	20248711	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatttggtactcttccattaCagcccctaaaatgctcatag	11	14	5	11	0	2	0	1	0	1	0	3	0	3	0	3	1	4	2	3	1	6	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:20248711C>A	uc010tku.1	+	1	230	c.230C>A	c.(229-231)ACA>AAA	p.T77K		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTCCATTACAGCCCCTAAA	0.438													203	595					2.46165e-77	3.88534e-77	1	0	A	20248711	A	A	20248711	3	1	39	1	0	0	0	0	1	0	0	0	11129	478	17	4	232	4	OR4M1	14	20248711	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08		20248711	87100829	343	8359											
OR4K2	390431	broad.mit.edu	37	chr14	20344521	20344521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttttctttatggtgttttCattgctttatgtggcaacaa	7	21	8	5	0	2	0	1	0	1	0	2	0	2	0	0	2	2	4	0	2	4	9			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:20344521C>T	uc001vwh.1	+	1	95	c.95C>T	c.(94-96)TCA>TTA	p.S32L		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATGGTGTTTTCATTGCTTTAT	0.413													188	525					0	0	0	0	T	20344521	T	T	20344521	3	4	39	1	0	0	0	0	1	0	0	0	11126	838	29	2	97	2	OR4K2	14	20344521	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	95810	20344521	87005019	344	8360											
TMEM55B	90809	broad.mit.edu	37	chr14	20928404	20928404	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcactttgcagataaggagAcagttacaggggcatcgaac	13	8	12	8	1	1	2	1	0	0	2	2	4	1	2	0	3	3	3	0	3	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:20928404A>T	uc001vxl.2	-	3	540	c.387T>A	c.(385-387)TGT>TGA	p.C129*	TMEM55B_uc001vxk.2_Nonsense_Mutation_p.C136*	NM_144568	NP_653169	Q86T03	TM55B_HUMAN	transmembrane protein 55B isoform 2	129						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		AGATAAGGAGACAGTTACAGG	0.493													10	89					0	0	0	0	T	20928404	T	T	20928404	4	4	39	1	0	0	0	0	0	1	0	0	16248	273	10	5	466	5	TMEM55B	14	20928404	Nonsense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	583883	20928404	86421136	345	8361											
SUPT16H	11198	broad.mit.edu	37	chr14	21831310	21831310	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctgcagtcatttcattcTggtgaatggaaaatccaatt	11	15	7	8	0	4	1	2	1	2	0	5	2	5	2	1	2	1	1	1	2	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:21831310T>G	uc001wao.2	-	13	1735	c.1396_splice	c.e13-1	p.N466_splice		NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation						DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CATTTCATTCTGGTGAATGGA	0.388													39	163					0	0	0	0	G	21831310	G	G	21831310	5	3	39	1	0	0	0	0	0	0	1	0	15462	1594	55	5	1805	5	SUPT16H	14	21831310	Splice_Site	SNP	T	TCGA-CN-4727-01A-01D-1434-08	902906	21831310	85518230	346	8362											
C14orf119	55017	broad.mit.edu	37	chr14	23567116	23567116	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggagcagcttagtgtgtcTggggcagaccgaccaccttc	7	9	13	12	1	1	1	0	0	1	1	2	3	1	2	3	3	2	3	3	3	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:23567116T>C	uc001wiu.2	+	2	291	c.249T>C	c.(247-249)TCT>TCC	p.S83S	ACIN1_uc001wit.3_5'Flank|ACIN1_uc010akg.2_5'Flank|ACIN1_uc010tnj.1_5'Flank	NM_017924	NP_060394	Q9NWQ9	CN119_HUMAN	chromosome 14 open reading frame 119	83											0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00649)		TTAGTGTGTCTGGGGCAGACC	0.527													41	167					0	0	0	0	C	23567116	C	C	23567116	2	2	39	1	0	0	0	0	0	0	0	1	1748	1567	55	5		5	C14orf119	14	23567116	Silent	SNP	T	TCGA-CN-4727-01A-01D-1434-08	1735806	23567116	83782424	347	8363											
PRKD1	5587	broad.mit.edu	37	chr14	30066838	30066838	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccccaacagaccacatgtCtagagagcgattgtagccct	12	7	9	13	1	1	2	0	0	1	2	1	5	1	2	4	0	3	1	4	0	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:30066838C>T	uc001wqh.2	-	16	2474	c.2293G>A	c.(2293-2295)GAC>AAC	p.D765N		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	765	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GACCACATGTCTAGAGAGCGA	0.493													34	157					0	0	0	0	T	30066838	T	T	30066838	3	4	39	1	0	0	0	0	1	0	0	0	12580	913	32	2	457	2	PRKD1	14	30066838	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	6499722	30066838	77282702	348	8364											
KIAA0586	9786	broad.mit.edu	37	chr14	58917324	58917324	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaagaagttgaagatacgaGttttgataaacagaaatctc	19	10	8	4	1	1	5	0	2	1	3	2	6	1	5	0	0	2	2	0	0	8	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:58917324G>A	uc001xdv.3	+	8	1262	c.989G>A	c.(988-990)AGT>AAT	p.S330N	KIAA0586_uc010trr.1_Missense_Mutation_p.S371N|KIAA0586_uc001xdt.3_Missense_Mutation_p.S286N|KIAA0586_uc001xdu.3_Missense_Mutation_p.S315N|KIAA0586_uc010trs.1_Missense_Mutation_p.S245N|KIAA0586_uc010trt.1_Missense_Mutation_p.S190N|KIAA0586_uc010tru.1_Missense_Mutation_p.S190N	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	330										ovary(1)	1						GAAGATACGAGTTTTGATAAA	0.328													16	33					0	0	0	0	A	58917324	A	A	58917324	3	1	39	1	0	0	0	0	1	0	0	0	8225	1029	36	4	1019	4	KIAA0586	14	58917324	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	28850486	58917324	48432216	349	8365											
DCAF5	8816	broad.mit.edu	37	chr14	69529205	69529205	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagcaccatgaaggctcCgttgaccaccctaccaatgc	10	9	7	15	1	1	2	1	2	0	0	2	2	2	2	5	1	3	3	5	1	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:69529205C>G	uc001xkp.2	-	8	1189	c.970G>C	c.(970-972)GGA>CGA	p.G324R	DCAF5_uc001xkq.2_Missense_Mutation_p.G323R	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	324						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2						ATGAAGGCTCCGTTGACCACC	0.413													12	93					0	0	0	0	G	69529205	G	G	69529205	3	3	39	1	0	0	0	0	1	0	0	0	4290	661	23	3	1866	3	DCAF5	14	69529205	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	10611881	69529205	37820335	350	8366											
ZNF410	57862	broad.mit.edu	37	chr14	74371737	74371737	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgagtctggctgtggtaaGcagtttactacagctggaaa	11	11	12	7	0	1	1	0	1	1	0	1	2	1	2	0	3	4	5	0	3	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:74371737G>A	uc001xoz.1	+	7	1046	c.864G>A	c.(862-864)AAG>AAA	p.K288K	ZNF410_uc001xoy.1_RNA|ZNF410_uc010ary.1_RNA|ZNF410_uc010tuf.1_RNA|ZNF410_uc010tug.1_Silent_p.K19K|ZNF410_uc010tuh.1_Silent_p.K215K|ZNF410_uc010tui.1_RNA|ZNF410_uc010arz.1_Silent_p.K305K|ZNF410_uc001xpa.1_Silent_p.K92K|ZNF410_uc001xpb.1_Silent_p.K288K|ZNF410_uc001xpc.1_Silent_p.K235K|ZNF410_uc010tuj.1_Silent_p.K92K	NM_021188	NP_067011	Q86VK4	ZN410_HUMAN	zinc finger protein 410	288	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00369)		GCTGTGGTAAGCAGTTTACTA	0.527													24	97					0	0	0	0	A	74371737	A	A	74371737	2	1	39	1	0	0	0	0	0	0	0	1	17957	962	34	4		4	ZNF410	14	74371737	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4842532	74371737	32977803	351	8367											
C14orf145	145508	broad.mit.edu	37	chr14	81259118	81259118	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatacctgattattcttgcCtgtcagttcatcaacagttt	9	18	5	9	0	4	1	3	1	1	0	4	1	4	1	2	0	3	2	2	0	4	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:81259118C>T	uc001xux.2	-	13	1717	c.1546G>A	c.(1546-1548)GGC>AGC	p.G516S	C14orf145_uc010asz.1_RNA	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	516	Potential.					centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		TTATTCTTGCCTGTCAGTTCA	0.383													39	212					0	0	0	0	T	81259118	T	T	81259118	3	4	39	1	0	0	0	0	1	0	0	0	1755	681	24	4	1786	4	C14orf145	14	81259118	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	6887381	81259118	26090422	352	8368											
ZC3H14	79882	broad.mit.edu	37	chr14	89041109	89041109	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taaaaaaattcaatcatgatGgagaagaggaggaagaagat	21	7	11	2	0	2	5	2	1	0	4	2	8	2	7	0	3	0	0	0	3	8	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:89041109G>T	uc001xww.2	+	7	1159	c.934G>T	c.(934-936)GGA>TGA	p.G312*	ZC3H14_uc010twd.1_Nonsense_Mutation_p.G312*|ZC3H14_uc010twe.1_Nonsense_Mutation_p.G312*|ZC3H14_uc001xwx.2_Nonsense_Mutation_p.G312*|ZC3H14_uc010twf.1_Nonsense_Mutation_p.G157*|ZC3H14_uc001xwy.2_Nonsense_Mutation_p.G278*|ZC3H14_uc010twg.1_Nonsense_Mutation_p.G157*|ZC3H14_uc001xxa.2_5'Flank	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	312						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						CAATCATGATGGAGAAGAGGA	0.413													10	55					0.000442599	0.000465275	1	0	T	89041109	T	T	89041109	4	4	39	1	0	0	0	0	0	1	0	0	17633	1349	47	4	960	4	ZC3H14	14	89041109	Nonsense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	7781991	89041109	18308431	353	8369											
CCDC88C	440193	broad.mit.edu	37	chr14	91763774	91763774	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttcagtgaggttttcagctCcttggtgtgggcgtgcagct	4	14	15	8	1	2	1	2	1	0	0	3	1	3	1	1	3	3	5	1	3	0	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:91763774C>T	uc010aty.2	-	22	3940	c.3841G>A	c.(3841-3843)GAG>AAG	p.E1281K		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1281	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				GTTTTCAGCTCCTTGGTGTGG	0.547													5	6					0	0	0	0	T	91763774	T	T	91763774	3	4	39	1	0	0	0	0	1	0	0	0	2878	864	30	2	2281	2	CCDC88C	14	91763774	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2722665	91763774	15585766	354	8370											
SLC24A4	123041	broad.mit.edu	37	chr14	92958015	92958015	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttgtcccctgcaggccttgGggacatggcagtctccaaca	7	9	12	13	0	1	0	0	0	1	0	3	1	2	1	4	4	2	3	4	4	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:92958015G>T	uc001yak.2	+	15	1517	c.1493G>T	c.(1492-1494)GGG>GTG	p.G498V	SLC24A4_uc001yai.2_Missense_Mutation_p.G451V|SLC24A4_uc010twm.1_Missense_Mutation_p.G496V|SLC24A4_uc001yaj.2_Missense_Mutation_p.G479V|SLC24A4_uc010auj.2_Missense_Mutation_p.G387V|SLC24A4_uc010twn.1_Missense_Mutation_p.G271V|SLC24A4_uc001yan.2_Missense_Mutation_p.G209V	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	515	Cytoplasmic (Potential).|Alpha-2.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		GCAGGCCTTGGGGACATGGCA	0.478													28	67					8.58068e-18	1.13725e-17	1	0	T	92958015	T	T	92958015	3	4	39	1	0	0	0	0	1	0	0	0	14532	1232	43	4	1551	4	SLC24A4	14	92958015	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1194241	92958015	14391525	355	8371											
SLC24A4	123041	broad.mit.edu	37	chr14	92958081	92958081	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggtaggacttggtgtacCgtggggcctgcagaccatgg	6	9	16	10	1	0	1	0	0	0	1	0	2	0	2	4	6	2	3	4	6	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:92958081C>A	uc001yak.2	+	15	1583	c.1559C>A	c.(1558-1560)CCG>CAG	p.P520Q	SLC24A4_uc001yai.2_Missense_Mutation_p.P473Q|SLC24A4_uc010twm.1_Missense_Mutation_p.P518Q|SLC24A4_uc001yaj.2_Missense_Mutation_p.P501Q|SLC24A4_uc010auj.2_Missense_Mutation_p.P409Q|SLC24A4_uc010twn.1_Missense_Mutation_p.P293Q|SLC24A4_uc001yan.2_Missense_Mutation_p.P231Q	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	537	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CTTGGTGTACCGTGGGGCCTG	0.483													34	93					6.70999e-13	8.31618e-13	1	0	A	92958081	A	A	92958081	3	1	39	1	0	0	0	0	1	0	0	0	14532	652	23	3	1617	3	SLC24A4	14	92958081	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	66	92958081	14391459	356	8372											
SERPINA3	12	broad.mit.edu	37	chr14	95080961	95080961	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacttcgctttcagcctgtaCaagcagttagtcctgaaggc	9	11	10	11	1	1	1	1	1	0	0	3	2	2	1	2	1	3	4	2	1	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:95080961C>A	uc001ydp.2	+	2	262	c.183C>A	c.(181-183)TAC>TAA	p.Y61*	SERPINA3_uc001ydo.3_Nonsense_Mutation_p.Y86*|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Nonsense_Mutation_p.Y61*|SERPINA3_uc001yds.2_Nonsense_Mutation_p.Y61*|SERPINA3_uc010avg.2_Nonsense_Mutation_p.Y61*	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	61					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TCAGCCTGTACAAGCAGTTAG	0.557													80	127					1.43161e-34	2.13202e-34	1	0	A	95080961	A	A	95080961	4	1	39	1	0	0	0	0	0	1	0	0	14155	489	17	4	185	4	SERPINA3	14	95080961	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2122880	95080961	12268579	357	8373											
DYNC1H1	1778	broad.mit.edu	37	chr14	102453804	102453804	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcaggtggatgatctgctGatcattgaagaaaaaataga	15	11	10	5	0	3	5	2	3	1	2	3	6	3	6	0	2	1	1	0	2	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:102453804G>T	uc001yks.2	+	9	2717	c.2553G>T	c.(2551-2553)CTG>CTT	p.L851L		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	851	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						ATGATCTGCTGATCATTGAAG	0.353													21	61					7.45023e-12	9.07126e-12	1	0	T	102453804	T	T	102453804	2	4	39	1	0	0	0	0	0	0	0	1	4863	1277	45	2		2	DYNC1H1	14	102453804	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	7372843	102453804	4895736	358	8374											
TDRD9	122402	broad.mit.edu	37	chr14	104474748	104474748	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctgcttttatatatttaaAggatgaacttaattggggac	12	17	8	4	0	1	1	0	1	1	0	1	3	1	3	0	3	2	1	0	3	7	9			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:104474748A>C	uc001yom.3	+	20	2083	c.2053_splice	c.e20-2	p.D685_splice	TDRD9_uc001yon.3_Splice_Site_p.D423_splice	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9						cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				ATATATTTAAAGGATGAACTT	0.264													32	57					0	0	0	0	C	104474748	C	C	104474748	5	2	39	1	0	0	0	0	0	0	1	0	15802	86	3	5	2129	5	TDRD9	14	104474748	Splice_Site	SNP	A	TCGA-CN-4727-01A-01D-1434-08	2020944	104474748	2874792	359	8375											
AHNAK2	113146	broad.mit.edu	37	chr14	105408280	105408280	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtggtcttgaggtcccccTgcatggagggaatgctcatg	7	10	14	10	0	2	1	1	1	1	0	3	3	3	3	2	4	2	2	2	4	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr14:105408280T>C	uc010axc.1	-	7	13628	c.13508A>G	c.(13507-13509)CAG>CGG	p.Q4503R	AHNAK2_uc001ypx.2_Missense_Mutation_p.Q4403R	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4503						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GAGGTCCCCCTGCATGGAGGG	0.597													42	211					0	0	0	0	C	105408280	C	C	105408280	3	2	39	1	0	0	0	0	1	0	0	0	415	1580	55	5	3883	5	AHNAK2	14	105408280	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	933532	105408280	1941260	360	8376											
OR4N4	283694	broad.mit.edu	37	chr15	22382673	22382673	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatttctgggcaacttggcCttcctggatgcatcctactc	6	15	8	12	0	1	0	0	0	1	0	4	1	3	1	3	3	3	2	3	3	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:22382673C>A	uc001yuc.1	+	7	1182	c.201C>A	c.(199-201)GCC>GCA	p.A67A	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Silent_p.A67A	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GCAACTTGGCCTTCCTGGATG	0.483													23	495					1.46156e-29	2.11411e-29	1	0	A	22382673	A	A	22382673	2	1	39	1	0	0	0	0	0	0	0	1	11132	668	24	4		4	OR4N4	15	22382673	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08		22382673	80148719	361	8377											
C15orf2	23742	broad.mit.edu	37	chr15	24921726	24921726	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcctgcttggaaggccctGccatgcccagcacacacagc	8	6	10	17	0	0	0	0	0	0	0	1	1	1	1	4	2	5	3	4	2	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:24921726G>C	uc001ywo.2	+	1	1186	c.712G>C	c.(712-714)GCC>CCC	p.A238P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	238					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GGAAGGCCCTGCCATGCCCAG	0.622													24	40					0	0	0	0	C	24921726	C	C	24921726	3	2	39	1	0	0	0	0	1	0	0	0	1790	1319	46	4	714	4	C15orf2	15	24921726	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2539053	24921726	77609666	362	8378											
ATP10A	57194	broad.mit.edu	37	chr15	25959218	25959218	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctccagcctgagaagcatGccgtcgctggacggggtgga	7	7	15	12	3	0	1	0	1	0	1	3	4	2	3	4	4	3	2	4	4	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:25959218G>A	uc010ayu.2	-	10	2053	c.1947C>T	c.(1945-1947)GGC>GGT	p.G649G		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	649	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TGAGAAGCATGCCGTCGCTGG	0.677													22	43					0	0	0	0	A	25959218	A	A	25959218	2	1	39	1	0	0	0	0	0	0	0	1	1118	1306	46	4		4	ATP10A	15	25959218	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1037492	25959218	76572174	363	8379											
FMN1	342184	broad.mit.edu	37	chr15	33261044	33261044	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agagtccagggggaggtgggGgtgcaagtcctgggggtggt	6	7	23	5	0	0	1	0	0	0	1	2	2	2	2	2	8	1	1	2	8	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:33261044G>T	uc001zhf.3	-	4	2189	c.2189C>A	c.(2188-2190)CCC>CAC	p.P730H		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	953	FH1.|Pro-rich.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		GGGAGGTGGGGGTGCAAGTCC	0.522													26	56					4.26978e-12	5.21026e-12	1	0	T	33261044	T	T	33261044	3	4	39	1	0	0	0	0	1	0	0	0	5981	1232	43	4	1457	4	FMN1	15	33261044	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	7301826	33261044	69270348	364	8380											
ACTC1	70	broad.mit.edu	37	chr15	35085611	35085611	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgctcctcgggagccacacGgagctcattgtagaaggtgt	8	9	14	10	2	1	1	1	0	0	1	3	3	2	3	2	3	3	3	2	3	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:35085611G>C	uc001ziu.1	-	3	532	c.289C>G	c.(289-291)CGT>GGT	p.R97G	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	97			R -> C (in CMH11).		apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GGAGCCACACGGAGCTCATTG	0.562													72	119					0	0	0	0	C	35085611	C	C	35085611	3	2	39	1	0	0	0	0	1	0	0	0	195	1116	39	3	864	3	ACTC1	15	35085611	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1824567	35085611	67445781	365	8381											
MEIS2	4212	broad.mit.edu	37	chr15	37388489	37388489	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtggatcaagaaggctggaCctgcttggcgaagaccgcga	11	6	15	9	3	1	2	1	0	0	2	1	6	1	4	2	4	1	2	2	4	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:37388489C>A	uc001zjr.2	-	3	1424	c.387_splice	c.e3+1	p.Q129_splice	MEIS2_uc001zjl.2_Splice_Site_p.Q116_splice|MEIS2_uc010ucj.1_Splice_Site_p.Q116_splice|MEIS2_uc001zjm.2_Splice_Site_p.Q41_splice|MEIS2_uc001zjn.2_Intron|MEIS2_uc001zjo.2_Splice_Site_p.Q129_splice|MEIS2_uc001zjp.2_Splice_Site_p.Q129_splice|MEIS2_uc001zjs.2_Splice_Site_p.Q129_splice|MEIS2_uc001zju.2_Splice_Site_p.Q116_splice|MEIS2_uc001zjt.2_Splice_Site_p.Q129_splice	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c						negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		GAAGGCTGGACCTGCTTGGCG	0.607													4	24					0.00024832	0.000262537	1	0	A	37388489	A	A	37388489	5	1	39	1	0	0	0	0	0	0	1	0	9521	521	18	4	1148	4	MEIS2	15	37388489	Splice_Site	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2302878	37388489	65142903	366	8382											
C15orf33	196951	broad.mit.edu	37	chr15	49869035	49869035	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgctttgaatcctgtgaagCtgcaaccctagaaagaggaa	13	10	10	8	0	0	4	0	2	0	2	1	5	1	5	2	1	4	3	2	1	6	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:49869035C>A	uc001zxl.2	-	7	743	c.449G>T	c.(448-450)AGC>ATC	p.S150I	C15orf33_uc001zxm.2_Missense_Mutation_p.S150I	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	150										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		TCCTGTGAAGCTGCAACCCTA	0.328													18	27					3.52763e-06	3.81701e-06	1	0	A	49869035	A	A	49869035	3	1	39	1	0	0	0	0	1	0	0	0	1797	797	28	4	1117	4	C15orf33	15	49869035	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	12480546	49869035	52662357	367	8383											
UNC13C	440279	broad.mit.edu	37	chr15	54307972	54307972	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaaccaaaacattcctgaaCagccagtggagatcacaaag	19	5	7	10	0	1	2	1	1	0	1	2	3	2	2	3	1	4	0	3	1	6	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:54307972C>T	uc002ack.2	+	1	2872	c.2872C>T	c.(2872-2874)CAG>TAG	p.Q958*		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	958					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CATTCCTGAACAGCCAGTGGA	0.403													4	21					0	0	0	0	T	54307972	T	T	54307972	4	4	39	1	0	0	0	0	0	1	0	0	17054	479	17	4	2874	4	UNC13C	15	54307972	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4438937	54307972	48223420	368	8384											
IQCH	64799	broad.mit.edu	37	chr15	67652185	67652185	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtctcattcttcattgtagGggaaaagcagaaggtcaaga	13	11	11	6	0	4	2	3	0	2	2	5	3	4	3	0	3	1	2	0	3	5	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:67652185G>T	uc002aqo.1	+	8	762	c.715G>T	c.(715-717)GGG>TGG	p.G239W	IQCH_uc010ujv.1_Intron|IQCH_uc002aqn.1_Missense_Mutation_p.G66W|IQCH_uc002aqq.1_5'UTR|IQCH_uc002aqp.1_5'UTR	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	239										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		TTCATTGTAGGGGAAAAGCAG	0.418													26	186					3.73148e-12	4.57354e-12	1	0	T	67652185	T	T	67652185	3	4	39	1	0	0	0	0	1	0	0	0	7850	1246	43	4	873	4	IQCH	15	67652185	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	13344213	67652185	34879207	369	8385											
ETFA	2108	broad.mit.edu	37	chr15	76588079	76588079	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaatcgtagcaatgaggcCtaaaaagagcaaaaaggaaa	21	5	10	5	1	0	3	0	2	0	1	1	4	0	4	1	2	2	3	1	2	9	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:76588079C>A	uc002bbt.2	-	2	121	c.40_splice	c.e2-1	p.A14_splice	ETFA_uc010bkq.1_Intron|ETFA_uc002bbu.1_Splice_Site_p.A14_splice	NM_000126	NP_000117	P13804	ETFA_HUMAN	electron transfer flavoprotein, alpha						respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity				0						GCAATGAGGCCTAAAAAGAGC	0.353													16	49					6.94344e-10	8.14972e-10	1	0	A	76588079	A	A	76588079	5	1	39	1	0	0	0	0	0	0	1	0	5293	695	24	4	1006	4	ETFA	15	76588079	Splice_Site	SNP	C	TCGA-CN-4727-01A-01D-1434-08	8935894	76588079	25943313	370	8386											
RASGRF1	5923	broad.mit.edu	37	chr15	79292140	79292140	+	Frame_Shift_Del	DEL	G	-	-																															ttgtttggggtgccctcgttGgccccggcggttgctatggc																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:79292140delG	uc002beq.2	-	18	3114	c.2739delC	c.(2737-2739)GCCfs	p.A913fs	RASGRF1_uc002bep.2_Frame_Shift_Del_p.A897fs|RASGRF1_uc010blm.1_Frame_Shift_Del_p.A822fs|RASGRF1_uc002ber.3_Frame_Shift_Del_p.A897fs|RASGRF1_uc010unh.1_Frame_Shift_Del_p.A308fs|RASGRF1_uc002beo.2_Frame_Shift_Del_p.A129fs	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	915					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						TGCCCTCGTTGGCCCCGGCGG	0.582													---	---	---								-	79292140	-	-	79292140	7	5	39	1	0	1	0	1	0	0	0	0	13137	1335	47	0	1126	0	RASGRF1	15	79292140	Frame_Shift_Del	DEL	G	TCGA-CN-4727-01A-01D-1434-08	2704061	79292140	23239252	371	8387											
FAH	2184	broad.mit.edu	37	chr15	80450432	80450432	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggataggtgtggccattggcGaccagatcctggacctcagc	8	8	14	11	1	1	1	1	0	0	1	2	4	2	3	4	5	1	0	4	5	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:80450432G>A	uc002bfj.2	+	3	194	c.112G>A	c.(112-114)GAC>AAC	p.D38N	FAH_uc002bfk.1_Missense_Mutation_p.D38N|FAH_uc002bfm.1_Missense_Mutation_p.D38N|FAH_uc002bfn.1_5'UTR|FAH_uc010unl.1_Missense_Mutation_p.D38N|FAH_uc002bfl.1_Missense_Mutation_p.D38N	NM_000137	NP_000128	P16930	FAAA_HUMAN	fumarylacetoacetase	38					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	fumarylacetoacetase activity|metal ion binding				0						GGCCATTGGCGACCAGATCCT	0.527									Tyrosinemia_type_1				41	202					0	0	0	0	A	80450432	A	A	80450432	3	1	39	1	0	0	0	0	1	0	0	0	5399	1058	37	1	118	1	FAH	15	80450432	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1158292	80450432	22080960	372	8388											
TMC3	342125	broad.mit.edu	37	chr15	81650821	81650821	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcttcctggctgtgcttccAaagggctggcctgcaatcag	6	11	12	12	0	2	0	1	0	1	0	4	0	4	0	3	3	2	4	3	3	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:81650821A>T	uc002bgo.1	-	6	522	c.522T>A	c.(520-522)TTT>TTA	p.F174L	TMC3_uc010blr.1_RNA|TMC3_uc002bgp.2_Missense_Mutation_p.F174L	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	174	Extracellular (Potential).					integral to membrane				ovary(1)|liver(1)	2						CTGTGCTTCCAAAGGGCTGGC	0.567													8	30					0	0	0	0	T	81650821	T	T	81650821	3	4	39	1	0	0	0	0	1	0	0	0	16052	127	5	5	2848	5	TMC3	15	81650821	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	1200389	81650821	20880571	373	8389											
AP3B2	8120	broad.mit.edu	37	chr15	83333627	83333627	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcctgactccccctcagaGtccgagtagaagggtttttc	7	10	12	12	1	1	3	1	1	0	2	4	4	3	3	4	2	0	2	4	2	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:83333627G>T	uc010uoh.1	-	17	2217	c.2040C>A	c.(2038-2040)GAC>GAA	p.D680E	AP3B2_uc010uoi.1_Missense_Mutation_p.D699E|AP3B2_uc010uoj.1_Missense_Mutation_p.D648E|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Missense_Mutation_p.D316E|AP3B2_uc002biy.1_5'Flank	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	680	Glu/Ser-rich.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			CCCCCTCAGAGTCCGAGTAGA	0.567													3	21					0.004672	0.0048289	1	0	T	83333627	T	T	83333627	3	4	39	1	0	0	0	0	1	0	0	0	745	1020	36	4	1248	4	AP3B2	15	83333627	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1682806	83333627	19197765	374	8390											
AP3B2	8120	broad.mit.edu	37	chr15	83335614	83335614	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagctgccgggtgaagcgCgcccggtcgcgaatatcata	9	7	14	11	6	1	2	1	2	0	0	2	3	1	2	2	2	3	1	2	2	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:83335614C>A	uc010uoh.1	-	15	1914	c.1737G>T	c.(1735-1737)GCG>GCT	p.A579A	AP3B2_uc010uoi.1_Silent_p.A579A|AP3B2_uc010uoj.1_Silent_p.A547A|AP3B2_uc010uog.1_Silent_p.A215A	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	579					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGGTGAAGCGCGCCCGGTCGC	0.597													28	92					1.04121e-07	1.17481e-07	1	0	A	83335614	A	A	83335614	2	1	39	1	0	0	0	0	0	0	0	1	745	755	27	3		3	AP3B2	15	83335614	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1987	83335614	19195778	375	8391											
SPATA8	145946	broad.mit.edu	37	chr15	97327404	97327404	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcgtcgcgacatttctcAgaagccatgacatgtccctg	9	10	8	14	3	1	2	1	1	1	1	5	3	2	2	3	0	1	0	3	0	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr15:97327404A>G	uc002bue.2	+	2	321	c.111A>G	c.(109-111)TCA>TCG	p.S37S	uc010urp.1_5'Flank|uc002bud.1_5'Flank	NM_173499	NP_775770	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	37										ovary(1)|skin(1)	2	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			GACATTTCTCAGAAGCCATGA	0.582													34	86					0	0	0	0	G	97327404	G	G	97327404	2	3	39	1	0	0	0	0	0	0	0	1	15081	175	7	5		5	SPATA8	15	97327404	Silent	SNP	A	TCGA-CN-4727-01A-01D-1434-08	13991790	97327404	5203988	376	8392											
PIGQ	9091	broad.mit.edu	37	chr16	632905	632905	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacccactgccctacagccGcgtggtgcacacctaccgcc	9	5	8	19	3	0	0	0	0	0	0	0	0	0	0	6	1	6	1	6	1	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr16:632905G>T	uc002cho.2	+	10	1656	c.1554G>T	c.(1552-1554)CCG>CCT	p.P518P	PIGQ_uc010bqw.2_Missense_Mutation_p.R539L|PIGQ_uc002chn.2_Missense_Mutation_p.R539L|PIGQ_uc010uui.1_3'UTR|PIGQ_uc002chp.2_Silent_p.P88P|uc010uuj.1_3'UTR	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	518	Leu-rich.				C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				CCCTACAGCCGCGTGGTGCAC	0.667													103	145					4.85316e-53	7.59506e-53	1	0	T	632905	T	T	632905	2	4	39	1	0	0	0	0	0	0	0	1	11951	1087	38	3		3	PIGQ	16	632905	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08		632905	89721848	377	8393											
CEMP1	752014	broad.mit.edu	37	chr16	2580803	2580803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggggttgatctcagcccaCaagccccaggggcagcccag	10	4	13	14	0	1	1	1	1	1	0	2	1	1	1	4	4	3	2	4	4	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr16:2580803C>T	uc002cqr.2	-	1	628	c.272G>A	c.(271-273)TGT>TAT	p.C91Y	AMDHD2_uc010uwc.1_3'UTR|AMDHD2_uc010uwd.1_3'UTR	NM_001048212	NP_001041677	Q6PRD7	CEMP1_HUMAN	cementum protein 1	91						cytoplasm				skin(1)	1						TCTCAGCCCACAAGCCCCAGG	0.657													29	47					0	0	0	0	T	2580803	T	T	2580803	3	4	39	1	0	0	0	0	1	0	0	0	3239	478	17	4	475	4	CEMP1	16	2580803	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1947898	2580803	87773950	378	8394											
XYLT1	64131	broad.mit.edu	37	chr16	17202577	17202577	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagccggccatcaggtttgActgcccccagctccgacttg	6	9	11	15	2	1	2	1	2	0	0	2	3	2	2	5	2	3	2	5	2	0	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr16:17202577A>G	uc002dfa.2	-	12	2940	c.2855T>C	c.(2854-2856)GTC>GCC	p.V952A		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	952	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						ATCAGGTTTGACTGCCCCCAG	0.662													5	42					0	0	0	0	G	17202577	G	G	17202577	3	3	39	1	0	0	0	0	1	0	0	0	17531	275	10	5	28	5	XYLT1	16	17202577	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	14621774	17202577	73152176	379	8395											
TNRC6A	27327	broad.mit.edu	37	chr16	24801674	24801674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagttaacacaaacaaaggaGgtggtgtgtgggaatctggt	14	9	14	4	0	1	0	0	0	1	0	1	2	1	2	0	5	2	1	0	5	5	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr16:24801674G>A	uc002dmm.2	+	6	1825	c.1711G>A	c.(1711-1713)GGT>AGT	p.G571S	TNRC6A_uc010bxs.2_Missense_Mutation_p.G318S|TNRC6A_uc010vcc.1_Missense_Mutation_p.G318S|TNRC6A_uc002dmn.2_Missense_Mutation_p.G318S|TNRC6A_uc002dmo.2_Missense_Mutation_p.G318S	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	571	Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		AAACAAAGGAGGTGGTGTGTG	0.488													27	96					0	0	0	0	A	24801674	A	A	24801674	3	1	39	1	0	0	0	0	1	0	0	0	16406	1000	35	4	1733	4	TNRC6A	16	24801674	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	7599097	24801674	65553079	380	8396											
ZNF720	124411	broad.mit.edu	37	chr16	31733987	31733987	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtggccatagaattctctcGggaggagtgggaacacctgg	9	9	15	8	1	1	1	0	0	1	1	3	4	1	4	2	5	1	0	2	5	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr16:31733987G>T	uc002ecn.3	+	2	248	c.44G>T	c.(43-45)CGG>CTG	p.R15L	ZNF720_uc010vfs.1_5'UTR|ZNF720_uc002eco.2_Intron|ZNF720_uc002ecp.1_Intron|ZNF720_uc002ecq.2_Missense_Mutation_p.R17L	NM_001130913	NP_001124385	Q7Z2F6	ZN720_HUMAN	zinc finger protein 720	15	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding				0						GAATTCTCTCGGGAGGAGTGG	0.458													31	123					9.85913e-13	1.21919e-12	1	0	T	31733987	T	T	31733987	3	4	39	1	0	0	0	0	1	0	0	0	18188	1116	39	3	50	3	ZNF720	16	31733987	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	6932313	31733987	58620766	381	8397											
ABCC11	85320	broad.mit.edu	37	chr16	48232119	48232119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttttctgcattaactcaCtgtgagttccattttcacag	8	17	5	11	0	3	1	2	1	1	0	4	1	4	1	2	0	2	2	2	0	1	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr16:48232119C>T	uc002eff.1	-	15	2500	c.2150G>A	c.(2149-2151)AGT>AAT	p.S717N	ABCC11_uc002efg.1_Missense_Mutation_p.S717N|ABCC11_uc002efh.1_Missense_Mutation_p.S717N|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	717	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CATTAACTCACTGTGAGTTCC	0.403									Cerumen_Type				30	150					0	0	0	0	T	48232119	T	T	48232119	3	4	39	1	0	0	0	0	1	0	0	0	51	565	20	4	2058	4	ABCC11	16	48232119	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	16498132	48232119	42122634	382	8398											
LONP2	83752	broad.mit.edu	37	chr16	48278415	48278415	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggactcggcccgcaaccTgcagctggtgcggagccgcc	5	5	15	16	5	0	0	0	0	0	0	1	2	0	2	4	4	5	3	4	4	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr16:48278415T>A	uc002efi.1	+	1	205	c.116T>A	c.(115-117)CTG>CAG	p.L39Q	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.L39Q|ABCC11_uc010vgl.1_Intron	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	39	Lon.				misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						GCCCGCAACCTGCAGCTGGTG	0.701													6	5					0	0	0	0	A	48278415	A	A	48278415	3	1	39	1	0	0	0	0	1	0	0	0	8943	1580	55	5	118	5	LONP2	16	48278415	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	46296	48278415	42076338	383	8399											
ZNF423	23090	broad.mit.edu	37	chr16	49669635	49669635	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccggcgtgaggtcacggTggtccacctgcatgtggctc	4	10	14	13	3	2	1	1	1	1	0	5	1	3	1	3	5	1	2	3	5	0	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr16:49669635T>A	uc002efs.2	-	5	3726	c.3428A>T	c.(3427-3429)CAC>CTC	p.H1143L	ZNF423_uc010vgn.1_Missense_Mutation_p.H1026L	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1143	C2H2-type 26.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GAGGTCACGGTGGTCCACCTG	0.672													35	181					0	0	0	0	A	49669635	A	A	49669635	3	1	39	1	0	0	0	0	1	0	0	0	17965	1696	59	5	446	5	ZNF423	16	49669635	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	1391220	49669635	40685118	384	8400											
HP	3240	broad.mit.edu	37	chr16	72094424	72094424	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttatgtttctggctgggggCgaaatgccaattttaaattt	9	16	11	5	1	1	0	0	0	1	0	1	1	1	0	1	3	1	3	1	3	5	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr16:72094424C>A	uc002fbr.3	+	7	900	c.856C>A	c.(856-858)CGA>AGA	p.R286R	TXNL4B_uc010cgl.2_Intron|HP_uc010cgm.2_Silent_p.R227R|HP_uc002fbt.3_Silent_p.R227R|HP_uc002fbu.1_Silent_p.R24R|HP_uc002fbv.3_Silent_p.R197R|HP_uc002fbw.3_Silent_p.R108R|HP_uc002fbx.3_Silent_p.R108R|HPR_uc002fby.2_5'Flank	NM_005143	NP_005134	P00738	HPT_HUMAN	haptoglobin isoform 1 preproprotein	286	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity				0		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		TGGCTGGGGGCGAAATGCCAA	0.468													39	33					6.29468e-14	7.88972e-14	1	0	A	72094424	A	A	72094424	2	1	39	1	0	0	0	0	0	0	0	1	7366	760	27	3		3	HP	16	72094424	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	22424789	72094424	18260329	385	8401											
ZNF778	197320	broad.mit.edu	37	chr16	89294059	89294059	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catacacgtgtaaggactgcGggaaagccttctgtacatcc	11	9	10	11	2	1	0	0	0	1	0	2	2	2	2	2	2	4	2	2	2	4	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr16:89294059G>T	uc002fmv.2	+	6	1618	c.1279G>T	c.(1279-1281)GGG>TGG	p.G427W	ZNF778_uc010vpf.1_Intron|ZNF778_uc002fmw.1_Missense_Mutation_p.G385W|ZNF778_uc010vpg.1_Missense_Mutation_p.G190W	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	427	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)		TAAGGACTGCGGGAAAGCCTT	0.502													21	109					1.10923e-09	1.29644e-09	1	0	T	89294059	T	T	89294059	3	4	39	1	0	0	0	0	1	0	0	0	18218	1116	39	3	1297	3	ZNF778	16	89294059	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	17199635	89294059	1060694	386	8402											
MYBBP1A	10514	broad.mit.edu	37	chr17	4442815	4442815	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttgcctttttccgtgccagCgcggacagtggtgatttgcc	4	13	12	12	3	0	1	0	1	0	0	1	2	1	2	4	2	4	0	4	2	0	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:4442815C>G	uc002fyb.3	-	26	3944	c.3882G>C	c.(3880-3882)GCG>GCC	p.A1294A	MYBBP1A_uc002fxz.3_Silent_p.A1294A|SPNS2_uc002fxx.2_3'UTR|SPNS2_uc002fxy.2_3'UTR|MYBBP1A_uc002fya.3_Silent_p.A239A|MYBBP1A_uc010vsa.1_Silent_p.A336A	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	1294	Required for nuclear and nucleolar localization (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						TCCGTGCCAGCGCGGACAGTG	0.582													92	398					0	0	0	0	G	4442815	G	G	4442815	2	3	39	1	0	0	0	0	0	0	0	1	10061	755	27	3		3	MYBBP1A	17	4442815	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08		4442815	76752395	387	8403											
ZMYND15	84225	broad.mit.edu	37	chr17	4646665	4646665	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcctcactcgtggctattgGacccagctcagcatgctgat	7	10	11	13	1	2	1	2	1	0	0	3	2	2	2	2	3	3	4	2	3	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:4646665G>C	uc002fyt.2	+	6	1251	c.1212G>C	c.(1210-1212)TGG>TGC	p.W404C	ZMYND15_uc002fyv.2_Missense_Mutation_p.W404C|ZMYND15_uc002fyu.2_Missense_Mutation_p.W404C	NM_032265	NP_115641	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15 isoform 2	404							zinc ion binding				0						GTGGCTATTGGACCCAGCTCA	0.612													139	270					0	0	0	0	C	4646665	C	C	4646665	3	2	39	1	0	0	0	0	1	0	0	0	17775	1183	41	2	1230	2	ZMYND15	17	4646665	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	203850	4646665	76548545	388	8404											
TP53	7157	broad.mit.edu	37	chr17	7577046	7577046	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgctccctgggggcagctCgtggtgaggctcccctttct	3	11	14	13	1	1	1	0	1	1	0	4	1	3	1	3	4	2	4	3	4	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:7577046C>A	uc002gim.2	-	8	1086	c.892G>T	c.(892-894)GAG>TAG	p.E298*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E298*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E166*|TP53_uc010cng.1_Nonsense_Mutation_p.E166*|TP53_uc002gii.1_Nonsense_Mutation_p.E166*|TP53_uc010cnh.1_Nonsense_Mutation_p.E298*|TP53_uc010cni.1_Nonsense_Mutation_p.E298*|TP53_uc002gij.2_Nonsense_Mutation_p.E298*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	298	Interaction with HIPK1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E298*(35)|p.0?(7)|p.E298K(2)|p.?(2)|p.E298V(2)|p.L299fs*2(1)|p.L265_K305del41(1)|p.E298A(1)|p.E298fs*53(1)|p.G293fs*1(1)|p.E298fs*47(1)|p.E298E(1)|p.E298Q(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGGCAGCTCGTGGTGAGGC	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			97	62					2.28585e-32	3.35016e-32	1	0	A	7577046	A	A	7577046	4	1	39	1	0	0	0	0	0	1	0	0	16448	893	31	3	394	3	TP53	17	7577046	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2930381	7577046	73618164	389	8405											
MYH13	8735	broad.mit.edu	37	chr17	10267796	10267796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctctccttctctggtttccGgaggtagggagctgcttctc	3	15	11	12	1	3	0	0	0	3	0	8	2	5	2	2	4	2	4	2	4	1	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:10267796G>A	uc002gmk.1	-	3	142	c.52C>T	c.(52-54)CGG>TGG	p.R18W		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	18	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCTGGTTTCCGGAGGTAGGGA	0.493													16	13					0	0	0	0	A	10267796	A	A	10267796	3	1	39	1	0	0	0	0	1	0	0	0	10085	1115	39	1	5920	1	MYH13	17	10267796	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2690750	10267796	70927414	390	8406											
MYH3	4621	broad.mit.edu	37	chr17	10545739	10545739	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcactcctcttaccatccGccgtggcaaacgtggcatag	10	8	9	14	3	1	0	0	0	1	0	3	0	3	0	4	2	3	3	4	2	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:10545739G>A	uc002gmq.1	-	15	1960	c.1883C>T	c.(1882-1884)GCG>GTG	p.A628V		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	628	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CTTACCATCCGCCGTGGCAAA	0.507													16	102					0	0	0	0	A	10545739	A	A	10545739	3	1	39	1	0	0	0	0	1	0	0	0	10089	1087	38	1	4043	1	MYH3	17	10545739	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	277943	10545739	70649471	391	8407											
DNAH9	1770	broad.mit.edu	37	chr17	11543689	11543689	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctttcagcaactttggacGcatcacacacccgtgagtat	10	11	7	13	2	2	1	2	1	0	0	3	2	3	2	2	1	2	3	2	1	2	3	rs111906560	byFrequency	TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:11543689G>C	uc002gne.2	+	10	1957	c.1889G>C	c.(1888-1890)CGC>CCC	p.R630P		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	630	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AACTTTGGACGCATCACACAC	0.557													37	179					0	0	0	0	C	11543689	C	C	11543689	3	2	39	1	0	0	0	0	1	0	0	0	4630	1087	38	3	1927	3	DNAH9	17	11543689	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	997950	11543689	69651521	392	8408											
ZNF18	7566	broad.mit.edu	37	chr17	11895761	11895761	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cataataccctctgcttaccCattgccacagtctctggggg	8	11	8	14	0	2	0	0	0	2	0	3	0	2	0	3	2	4	1	3	2	3	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:11895761C>T	uc002gng.1	-	4	991	c.386G>A	c.(385-387)TGG>TAG	p.W129*	ZNF18_uc002gnh.1_Nonsense_Mutation_p.W129*|ZNF18_uc002gni.1_Nonsense_Mutation_p.W129*	NM_144680	NP_653281	P17022	ZNF18_HUMAN	zinc finger protein 18	129					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)	1				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		TCTGCTTACCCATTGCCACAG	0.458													44	79					0	0	0	0	T	11895761	T	T	11895761	4	4	39	1	0	0	0	0	0	1	0	0	17814	608	21	4	1287	4	ZNF18	17	11895761	Nonsense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	352072	11895761	69299449	393	8409											
SLC5A10	125206	broad.mit.edu	37	chr17	18862478	18862478	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccctcttcgccagcagcgagGgctctggcctcttcattgga	5	10	11	15	2	4	0	1	0	3	0	5	2	4	1	3	3	2	2	3	3	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:18862478G>T	uc002guu.1	+	3	255	c.214G>T	c.(214-216)GGC>TGC	p.G72C	SLC5A10_uc002gur.1_Missense_Mutation_p.G16C|SLC5A10_uc002gut.1_Missense_Mutation_p.G72C|SLC5A10_uc002guv.1_Missense_Mutation_p.G72C|SLC5A10_uc010vyl.1_Missense_Mutation_p.G72C	NM_001042450	NP_001035915	A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/glucose	72	Cytoplasmic (Potential).				sodium ion transport|transmembrane transport	integral to membrane	transporter activity			ovary(1)	1						CAGCAGCGAGGGCTCTGGCCT	0.652													13	58					7.88262e-20	1.06252e-19	1	0	T	18862478	T	T	18862478	3	4	39	1	0	0	0	0	1	0	0	0	14726	1232	43	4	224	4	SLC5A10	17	18862478	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	6966717	18862478	62332732	394	8410											
MPP2	4355	broad.mit.edu	37	chr17	41959835	41959836	+	Frame_Shift_Del	DEL	GC	-	-																															accatgcccccatgcagaatGcgcgcgatcaccagctcgcc																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:41959835_41959836delGC	uc010wip.1	-	6	689_690	c.632_633delGC	c.(631-633)CGCfs	p.R211fs	MPP2_uc002ien.1_Frame_Shift_Del_p.R183fs|MPP2_uc010wim.1_Frame_Shift_Del_p.R155fs|MPP2_uc002ieo.1_Frame_Shift_Del_p.R166fs|MPP2_uc010win.1_Frame_Shift_Del_p.R27fs|MPP2_uc010wio.1_Frame_Shift_Del_p.R155fs|MPP2_uc010czm.1_Frame_Shift_Del_p.R149fs	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	190	PDZ.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CATGCAGAATGCGCGCGATCAC	0.609													---	---	---								-	41959836	-	-	41959835	7	5	39	1	0	1	0	1	0	0	0	0	9787	1306	46	0	1192	0	MPP2	17	41959835	Frame_Shift_Del	DEL	GC	TCGA-CN-4727-01A-01D-1434-08	23097357	41959835	39235375	395	8411											
C17orf57	124989	broad.mit.edu	37	chr17	45419337	45419337	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaaagtcctctgatttttCaggagaaaaaaaagttggga	17	10	10	4	0	2	3	1	1	1	2	3	5	3	4	1	2	0	1	1	2	6	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:45419337C>T	uc002iln.2	+	6	653	c.242C>T	c.(241-243)TCA>TTA	p.S81L	ITGB3_uc010wkr.1_RNA|C17orf57_uc002ilm.2_Missense_Mutation_p.S81L|C17orf57_uc002ill.1_5'UTR|C17orf57_uc010daz.1_Missense_Mutation_p.S81L	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	81							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						TCTGATTTTTCAGGAGAAAAA	0.289													15	41					0	0	0	0	T	45419337	T	T	45419337	3	4	39	1	0	0	0	0	1	0	0	0	1872	838	29	2	252	2	C17orf57	17	45419337	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3459502	45419337	35775873	396	8412											
NGFR	4804	broad.mit.edu	37	chr17	47589374	47589374	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccgtggacagccagagcctGcatgaccagcagccccacac	10	4	10	17	1	0	2	0	1	0	1	1	3	1	3	6	1	5	2	6	1	0	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:47589374G>A	uc002ioz.3	+	5	1067	c.942G>A	c.(940-942)CTG>CTA	p.L314L		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	314	Cytoplasmic (Potential).				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					GCCAGAGCCTGCATGACCAGC	0.637													20	27					0	0	0	0	A	47589374	A	A	47589374	2	1	39	1	0	0	0	0	0	0	0	1	10450	1306	46	4		4	NGFR	17	47589374	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2170037	47589374	33605836	397	8413											
CA10	56934	broad.mit.edu	37	chr17	49713340	49713340	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctctggatatagttcctctAtattaagcccctgtagtaaa	11	15	6	9	0	2	0	0	0	2	0	4	1	3	1	3	1	1	3	3	1	8	8			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:49713340A>G	uc002itw.3	-	7	1651	c.665T>C	c.(664-666)ATA>ACA	p.I222T	CA10_uc002itu.3_Missense_Mutation_p.I151T|CA10_uc002itv.3_Missense_Mutation_p.I228T|CA10_uc002itx.3_Missense_Mutation_p.I222T|CA10_uc002ity.3_Missense_Mutation_p.I222T|CA10_uc002itz.2_Missense_Mutation_p.I222T	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	222					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TAGTTCCTCTATATTAAGCCC	0.368													33	109					0	0	0	0	G	49713340	G	G	49713340	3	3	39	1	0	0	0	0	1	0	0	0	2523	449	16	5	333	5	CA10	17	49713340	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	2123966	49713340	31481870	398	8414											
PSMC5	5705	broad.mit.edu	37	chr17	61905529	61905529	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggaggggaaggcaggcagcgGactccgccaatattatctgt	10	7	15	9	2	1	0	0	0	1	0	2	3	2	3	2	6	1	2	2	6	4	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:61905529G>T	uc002jcb.2	+	2	97	c.56G>T	c.(55-57)GGA>GTA	p.G19V	FTSJ3_uc002jbz.2_5'Flank|FTSJ3_uc002jca.2_5'Flank|PSMC5_uc010ddy.2_5'UTR|PSMC5_uc010ddz.2_5'UTR|PSMC5_uc002jcc.2_Missense_Mutation_p.G11V|PSMC5_uc002jcd.2_Missense_Mutation_p.G11V	NM_002805	NP_002796	P62195	PRS8_HUMAN	proteasome 26S ATPase subunit 5	19					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of programmed cell death|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|thyrotropin-releasing hormone receptor binding|transcription cofactor activity|transcription factor binding			large_intestine(1)	1						GCAGGCAGCGGACTCCGCCAA	0.542													29	65					8.16721e-17	1.06713e-16	1	0	T	61905529	T	T	61905529	3	4	39	1	0	0	0	0	1	0	0	0	12752	1174	41	2	62	2	PSMC5	17	61905529	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	12192189	61905529	19289681	399	8415											
SCN4A	6329	broad.mit.edu	37	chr17	62049720	62049720	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggcaggatatgcatggatGagcaccttgatggccccgcg	8	8	15	10	2	0	2	0	2	0	0	0	4	0	4	3	4	2	3	3	4	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:62049720G>A	uc002jds.1	-	2	461	c.384C>T	c.(382-384)CTC>CTT	p.L128L		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	128	I.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	ATGCATGGATGAGCACCTTGA	0.612													6	29					0	0	0	0	A	62049720	A	A	62049720	2	1	39	1	0	0	0	0	0	0	0	1	13985	1277	45	2		2	SCN4A	17	62049720	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	144191	62049720	19145490	400	8416											
SCN4A	6329	broad.mit.edu	37	chr17	62049989	62049989	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atgccgatgacctccggcggGgggtctccgtagatcatggg	6	8	16	11	4	2	2	1	1	1	1	4	3	3	2	4	5	1	1	4	5	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:62049989G>T	uc002jds.1	-	1	290	c.213C>A	c.(211-213)CCC>CCA	p.P71P		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	71					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	CCTCCGGCGGGGGGTCTCCGT	0.542													3	15					6.4e-05	6.81996e-05	1	0	T	62049989	T	T	62049989	2	4	39	1	0	0	0	0	0	0	0	1	13985	1219	43	4		4	SCN4A	17	62049989	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	269	62049989	19145221	401	8417											
LRRC37A3	374819	broad.mit.edu	37	chr17	62855907	62855907	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgggctcgggggacaggtCagtgcccacgttgttgtatt	5	13	15	8	2	1	0	1	0	0	0	2	1	1	1	1	4	1	4	1	4	1	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:62855907C>A	uc002jey.2	-	11	4888	c.4357G>T	c.(4357-4359)GAC>TAC	p.D1453Y	LRRC37A3_uc010wqg.1_Missense_Mutation_p.D571Y|LRRC37A3_uc002jex.1_Missense_Mutation_p.D430Y|LRRC37A3_uc010wqf.1_Missense_Mutation_p.D491Y|LRRC37A3_uc010dek.1_Missense_Mutation_p.D459Y	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1453	Extracellular (Potential).					integral to membrane					0						GGGGACAGGTCAGTGCCCACG	0.502													26	125					1.13719e-10	1.34904e-10	1	0	A	62855907	A	A	62855907	3	1	39	1	0	0	0	0	1	0	0	0	9043	826	29	2	563	2	LRRC37A3	17	62855907	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	805918	62855907	18339303	402	8418											
HELZ	9931	broad.mit.edu	37	chr17	65147297	65147297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcaaacagtactgatgcaCaactgggtggacagtcttta	13	10	10	8	0	2	1	1	1	1	0	2	3	2	2	0	2	4	2	0	2	4	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:65147297C>T	uc010wqk.1	-	18	2411	c.2224G>A	c.(2224-2226)GTG>ATG	p.V742M	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.V741M	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TACTGATGCACAACTGGGTGG	0.378													31	153					0	0	0	0	T	65147297	T	T	65147297	3	4	39	1	0	0	0	0	1	0	0	0	7088	478	17	4	3671	4	HELZ	17	65147297	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2291390	65147297	16047913	403	8419											
SOX9	6662	broad.mit.edu	37	chr17	70120399	70120399	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctctactccaccttcacCtacatgaaccccgctcagcg	8	8	6	19	2	3	1	2	1	1	0	4	1	4	1	6	1	4	1	6	1	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:70120399C>A	uc002jiw.2	+	3	1773	c.1401C>A	c.(1399-1401)ACC>ACA	p.T467T		NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	467					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CCACCTTCACCTACATGAACC	0.642													29	135					0.000184323	0.000195998	1	0	A	70120399	A	A	70120399	2	1	39	1	0	0	0	0	0	0	0	1	15022	668	24	4		4	SOX9	17	70120399	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4973102	70120399	11074811	404	8420											
UBE2O	63893	broad.mit.edu	37	chr17	74388027	74388027	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggaggctgacacacacCttcccattgtcatacaggtt	10	9	8	14	0	1	1	1	1	0	0	2	2	2	2	3	3	1	2	3	3	1	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:74388027C>G	uc002jrm.3	-	16	3179	c.3114G>C	c.(3112-3114)AAG>AAC	p.K1038N	UBE2O_uc002jrl.3_Missense_Mutation_p.K642N	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	1038							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						TGACACACACCTTCCCATTGT	0.607													8	27					0	0	0	0	G	74388027	G	G	74388027	3	3	39	1	0	0	0	0	1	0	0	0	16936	680	24	4	776	4	UBE2O	17	74388027	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4267628	74388027	6807183	405	8421											
TBC1D16	125058	broad.mit.edu	37	chr17	77914883	77914883	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggatccggggcaggaggcgGaactggtacagcaaactcct	10	5	16	10	2	0	0	0	0	0	0	2	3	2	3	2	7	4	3	2	7	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:77914883G>A	uc002jxj.2	-	12	2195	c.2079C>T	c.(2077-2079)TTC>TTT	p.F693F	uc002jxg.1_5'Flank|TBC1D16_uc002jxh.2_Silent_p.F331F|TBC1D16_uc002jxi.2_Silent_p.F318F	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	693						intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			GCAGGAGGCGGAACTGGTACA	0.677													3	18					0	0	0	0	A	77914883	A	A	77914883	2	1	39	1	0	0	0	0	0	0	0	1	15671	1165	41	2		2	TBC1D16	17	77914883	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	3526856	77914883	3280327	406	8422											
TMEM105	284186	broad.mit.edu	37	chr17	79287662	79287662	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccccaaggagaccgaggtGgggacccctggggagacgtc	8	3	16	14	2	0	2	0	0	0	2	1	6	0	3	6	6	0	0	6	6	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr17:79287662G>A	uc002kad.1	-	3	729	c.179C>T	c.(178-180)CCA>CTA	p.P60L		NM_178520	NP_848615	Q8N8V8	TM105_HUMAN	transmembrane protein 105	60						integral to membrane				ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			AGACCGAGGTGGGGACCCCTG	0.632													28	131					0	0	0	0	A	79287662	A	A	79287662	3	1	39	1	0	0	0	0	1	0	0	0	16085	1348	47	4	214	4	TMEM105	17	79287662	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1372779	79287662	1907548	407	8423											
LAMA1	284217	broad.mit.edu	37	chr18	6956666	6956666	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggctctggcaagagcttgCtgtcctctgcatcgggagcc	5	9	15	12	1	2	1	0	0	2	1	4	2	3	2	2	4	4	5	2	4	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr18:6956666C>A	uc002knm.2	-	56	8157	c.8063G>T	c.(8062-8064)AGC>ATC	p.S2688I	LAMA1_uc002knk.2_5'Flank|LAMA1_uc002knl.2_Missense_Mutation_p.S141I|LAMA1_uc010wzj.1_Missense_Mutation_p.S2164I	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2688					axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAGAGCTTGCTGTCCTCTGC	0.552													23	170					1.22574e-08	1.40301e-08	1	0	A	6956666	A	A	6956666	3	1	39	1	0	0	0	0	1	0	0	0	8645	797	28	4	1196	4	LAMA1	18	6956666	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08		6956666	71120582	408	8424											
LAMA1	284217	broad.mit.edu	37	chr18	7038870	7038870	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgccaaagcagaagcactcgGagcagccccgggggtttttt	9	7	13	12	3	0	1	0	0	0	1	1	2	0	2	3	3	4	4	3	3	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr18:7038870G>C	uc002knm.2	-	11	1596	c.1502C>G	c.(1501-1503)TCC>TGC	p.S501C	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	501	Laminin EGF-like 4.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAAGCACTCGGAGCAGCCCCG	0.537													105	365					0	0	0	0	C	7038870	C	C	7038870	3	2	39	1	0	0	0	0	1	0	0	0	8645	1174	41	2	7937	2	LAMA1	18	7038870	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	82204	7038870	71038378	409	8425											
CDH20	28316	broad.mit.edu	37	chr18	59221456	59221456	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattttgtccatgaggcggcAccggaaacaaccatacatca	13	8	8	12	2	1	1	1	1	0	0	2	2	2	2	3	3	3	1	3	3	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr18:59221456A>C	uc010dps.1	+	11	1946	c.1934A>C	c.(1933-1935)CAC>CCC	p.H645P	CDH20_uc002lif.2_Missense_Mutation_p.H639P	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	645	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				ATGAGGCGGCACCGGAAACAA	0.557													52	53					0	0	0	0	C	59221456	C	C	59221456	3	2	39	1	0	0	0	0	1	0	0	0	3121	159	6	5	1976	5	CDH20	18	59221456	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	52182586	59221456	18855792	410	8426											
SERPINB2	5055	broad.mit.edu	37	chr18	61569789	61569789	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaattgccgatgtgtccaCtggcttggagctggtaagac	9	11	13	8	1	0	2	0	1	0	1	1	4	1	3	2	3	2	3	2	3	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr18:61569789C>A	uc010xeu.1	+	8	1163	c.830C>A	c.(829-831)ACT>AAT	p.T277N	SERPINB2_uc002ljo.2_Missense_Mutation_p.T277N|SERPINB2_uc010dqh.2_Missense_Mutation_p.T207N|SERPINB2_uc002ljp.1_Missense_Mutation_p.T82N|SERPINB2_uc002ljq.1_Missense_Mutation_p.T82N	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	277					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	GATGTGTCCACTGGCTTGGAG	0.418													83	96					7.49063e-41	1.14953e-40	1	0	A	61569789	A	A	61569789	3	1	39	1	0	0	0	0	1	0	0	0	14166	565	20	4	852	4	SERPINB2	18	61569789	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2348333	61569789	16507459	411	8427											
CDH19	28513	broad.mit.edu	37	chr18	64197182	64197182	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cttgcacatacagtgggatcGaagagatctgttctatattg	11	13	10	7	1	2	1	0	0	2	1	3	4	2	2	0	1	2	2	0	1	4	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr18:64197182G>C	uc002lkc.1	-	9	1496	c.1358C>G	c.(1357-1359)TCG>TGG	p.S453W	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.S453W	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	453	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CAGTGGGATCGAAGAGATCTG	0.303													66	53					0	0	0	0	C	64197182	C	C	64197182	3	2	39	1	0	0	0	0	1	0	0	0	3119	1059	37	3	976	3	CDH19	18	64197182	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2627393	64197182	13880066	412	8428											
DSEL	92126	broad.mit.edu	37	chr18	65181244	65181244	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatttcctcagtaataaccCatattttttccaggtatttt	11	18	3	9	0	1	0	1	0	0	0	3	0	3	0	3	1	1	2	3	1	4	10			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr18:65181244C>G	uc002lke.1	-	2	1856	c.632G>C	c.(631-633)TGG>TCG	p.W211S		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	201						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				AGTAATAACCCATATTTTTTC	0.383													41	38					0	0	0	0	G	65181244	G	G	65181244	3	3	39	1	0	0	0	0	1	0	0	0	4797	595	21	4	3040	4	DSEL	18	65181244	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	984062	65181244	12896004	413	8429											
APC2	10297	broad.mit.edu	37	chr19	1455209	1455209	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctctggtactactctcagCtgcagggcctgtccaagcgc	7	9	11	14	1	2	0	1	0	2	0	4	0	3	0	2	2	6	4	2	2	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:1455209C>G	uc002lsr.1	+	5	683	c.475C>G	c.(475-477)CTG>GTG	p.L159V	APC2_uc002lss.1_5'UTR|APC2_uc002lst.1_Missense_Mutation_p.L159V|APC2_uc002lsu.1_Missense_Mutation_p.L159V	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	159					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTACTCTCAGCTGCAGGGCCT	0.682													8	14					0	0	0	0	G	1455209	G	G	1455209	3	3	39	1	0	0	0	0	1	0	0	0	764	796	28	4	489	4	APC2	19	1455209	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08		1455209	57673774	414	8430											
TICAM1	148022	broad.mit.edu	37	chr19	4818041	4818041	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcggacggcttcctggtaggCcacgtcccgcagcgaggcgg	5	5	17	14	6	0	0	0	0	0	0	2	2	2	1	3	6	1	3	3	6	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:4818041C>T	uc002mbi.2	-	2	600	c.349G>A	c.(349-351)GCC>ACC	p.A117T		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	117					apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		TCCTGGTAGGCCACGTCCCGC	0.677													17	80					0	0	0	0	T	4818041	T	T	4818041	3	4	39	1	0	0	0	0	1	0	0	0	15958	739	26	4	1793	4	TICAM1	19	4818041	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3362832	4818041	54310942	415	8431											
TMEM146	257062	broad.mit.edu	37	chr19	5768221	5768221	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcatcctggaccccttgacCctgcaagacaattacagctt	10	9	8	14	0	0	2	0	1	0	1	1	3	1	3	4	2	3	3	4	2	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:5768221C>G	uc002mda.2	+	18	1663	c.1602C>G	c.(1600-1602)ACC>ACG	p.T534T	TMEM146_uc010duj.1_Silent_p.T192T	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	534	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACCCCTTGACCCTGCAAGACA	0.522													17	129					0	0	0	0	G	5768221	G	G	5768221	2	3	39	1	0	0	0	0	0	0	0	1	16126	610	22	4		4	TMEM146	19	5768221	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	950180	5768221	53360762	416	8432											
GTF2F1	2962	broad.mit.edu	37	chr19	6389458	6389458	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accgccccaccacttacttcCtgcctgatttgccgttgacc	6	11	6	18	2	0	2	0	2	0	0	1	2	1	2	8	0	3	1	8	0	1	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:6389458C>A	uc002meq.2	-	4	608	c.323G>T	c.(322-324)AGG>ATG	p.R108M	GTF2F1_uc010xjb.1_5'Flank|GTF2F1_uc010xjc.1_Missense_Mutation_p.R80M	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	108					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						CACTTACTTCCTGCCTGATTT	0.612													85	119					4.869e-31	7.11722e-31	1	0	A	6389458	A	A	6389458	3	1	39	1	0	0	0	0	1	0	0	0	6897	681	24	4	1270	4	GTF2F1	19	6389458	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	621237	6389458	52739525	417	8433											
SLC25A41	284427	broad.mit.edu	37	chr19	6430127	6430127	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccctcctggaccatgctctGtagcccccccagcaggttgg	5	8	11	17	0	1	0	0	0	1	0	2	1	2	1	6	3	3	4	6	3	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:6430127G>C	uc010dus.2	-	3	495	c.409C>G	c.(409-411)CAG>GAG	p.Q137E	SLC25A41_uc010dut.2_5'UTR	NM_173637	NP_775908	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	137	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						ACCATGCTCTGTAGCCCCCCC	0.617													15	16					0	0	0	0	C	6430127	C	C	6430127	3	2	39	1	0	0	0	0	1	0	0	0	14570	1386	48	4	723	4	SLC25A41	19	6430127	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	40669	6430127	52698856	418	8434											
C3	718	broad.mit.edu	37	chr19	6686812	6686812	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccttcagcctgcccatctgGgccagagcatagccagcaat	9	7	9	16	0	2	1	1	0	1	1	2	1	2	1	5	1	5	2	5	1	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:6686812G>A	uc002mfm.2	-	28	3653	c.3591C>T	c.(3589-3591)GCC>GCT	p.A1197A	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1197					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGCCCATCTGGGCCAGAGCAT	0.542													132	196					0	0	0	0	A	6686812	A	A	6686812	2	1	39	1	0	0	0	0	0	0	0	1	2214	1219	43	4		4	C3	19	6686812	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	256685	6686812	52442171	419	8435											
C3	718	broad.mit.edu	37	chr19	6707204	6707204	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagggagatgaaacgggtccGgcgctggcacgagaacctca	11	4	15	11	4	1	3	1	1	0	2	2	5	2	3	2	4	2	2	2	4	2	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:6707204G>C	uc002mfm.2	-	17	2190	c.2128C>G	c.(2128-2130)CGG>GGG	p.R710G		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	710	Anaphylatoxin-like.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		AAACGGGTCCGGCGCTGGCAC	0.657													13	53					0	0	0	0	C	6707204	C	C	6707204	3	2	39	1	0	0	0	0	1	0	0	0	2214	1115	39	3	2963	3	C3	19	6707204	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	20392	6707204	52421779	420	8436											
KEAP1	9817	broad.mit.edu	37	chr19	10610576	10610576	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggtgcggttgccatgctggGagggcgtcacctccgccttg	4	9	16	12	3	1	0	1	0	0	0	2	1	2	1	4	4	3	2	4	4	0	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:10610576G>T	uc002moq.1	-	2	290	c.134C>A	c.(133-135)TCC>TAC	p.S45Y	KEAP1_uc002mor.1_Missense_Mutation_p.S45Y	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	45					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding	p.S45S(1)		lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GCCATGCTGGGAGGGCGTCAC	0.637													39	168					7.05121e-23	9.79041e-23	1	0	T	10610576	T	T	10610576	3	4	39	1	0	0	0	0	1	0	0	0	8180	1174	41	2	1760	2	KEAP1	19	10610576	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	3903372	10610576	48518407	421	8437											
SMARCA4	6597	broad.mit.edu	37	chr19	11144002	11144002	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgagcccaccgcatcgggCagcagaacgaggtgcgtgtg	9	4	15	13	5	0	1	0	0	0	1	1	3	0	1	3	2	4	3	3	2	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:11144002C>A	uc002mqf.3	+	26	3867	c.3583C>A	c.(3583-3585)CAG>AAG	p.Q1195K	SMARCA4_uc010dxp.2_Missense_Mutation_p.Q1195K|SMARCA4_uc010dxo.2_Missense_Mutation_p.Q1195K|SMARCA4_uc010dxq.2_Missense_Mutation_p.Q1195K|SMARCA4_uc010dxr.2_Missense_Mutation_p.Q1195K|SMARCA4_uc002mqj.3_Missense_Mutation_p.Q1195K|SMARCA4_uc010dxs.2_Missense_Mutation_p.Q1195K|SMARCA4_uc010dxt.1_Missense_Mutation_p.Q415K|SMARCA4_uc002mqh.3_Missense_Mutation_p.Q318K|SMARCA4_uc002mqi.1_Missense_Mutation_p.Q398K	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1195	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CCGCATCGGGCAGCAGAACGA	0.612			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				27	107					6.32553e-13	7.85727e-13	1	0	A	11144002	A	A	11144002	3	1	39	1	0	0	0	0	1	0	0	0	14834	711	25	4	3681	4	SMARCA4	19	11144002	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	533426	11144002	47984981	422	8438											
LPHN1	22859	broad.mit.edu	37	chr19	14268735	14268735	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagcgaagttggtgaggtGgctgcaggcacacgtggtat	9	8	16	8	2	0	1	0	1	0	0	0	2	0	1	0	5	2	5	0	5	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:14268735G>A	uc010xnn.1	-	14	2805	c.2509C>T	c.(2509-2511)CAC>TAC	p.H837Y	LPHN1_uc010xno.1_Missense_Mutation_p.H832Y|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	837	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						TTGGTGAGGTGGCTGCAGGCA	0.607													29	72					0	0	0	0	A	14268735	A	A	14268735	3	1	39	1	0	0	0	0	1	0	0	0	8965	1348	47	4	1959	4	LPHN1	19	14268735	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	3124733	14268735	44860248	423	8439											
OR7A5	26659	broad.mit.edu	37	chr19	14938984	14938984	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcccaaagaggaagggttGcagtccaggttcttgtgaaa	12	8	13	8	0	1	2	0	1	1	1	2	3	2	3	2	3	2	3	2	3	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:14938984G>T	uc002mzw.2	-	1	293	c.70C>A	c.(70-72)CAA>AAA	p.Q24K	OR7A5_uc010xoa.1_Missense_Mutation_p.Q24K	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						AGGAAGGGTTGCAGTCCAGGT	0.473													43	69					7.63091e-17	9.99415e-17	1	0	T	14938984	T	T	14938984	3	4	39	1	0	0	0	0	1	0	0	0	11270	1328	46	4	893	4	OR7A5	19	14938984	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	670249	14938984	44189999	424	8440											
NOTCH3	4854	broad.mit.edu	37	chr19	15299972	15299972	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acgcacctgcccaagtgctcGcaggggttggcgcctgccgg	5	6	15	15	4	0	0	0	0	0	0	1	0	0	0	4	4	3	4	4	4	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:15299972G>A	uc002nan.2	-	8	1282	c.1206C>T	c.(1204-1206)TGC>TGT	p.C402C	NOTCH3_uc002nao.1_Silent_p.C402C	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	402	Extracellular (Potential).|EGF-like 10; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CCAAGTGCTCGCAGGGGTTGG	0.652													19	65					0	0	0	0	A	15299972	A	A	15299972	2	1	39	1	0	0	0	0	0	0	0	1	10604	1079	38	1		1	NOTCH3	19	15299972	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	360988	15299972	43829011	425	8441											
OR10H1	26539	broad.mit.edu	37	chr19	15918353	15918353	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgtgtccacagaaggcgagGtggaaaatggccgaggtcac	11	7	15	8	2	1	1	1	0	0	1	2	4	2	2	2	5	0	0	2	5	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:15918353G>A	uc002nbq.2	-	1	584	c.495C>T	c.(493-495)CAC>CAT	p.H165H		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGAAGGCGAGGTGGAAAATGG	0.607													50	73					0	0	0	0	A	15918353	A	A	15918353	2	1	39	1	0	0	0	0	0	0	0	1	10959	1252	44	4		4	OR10H1	19	15918353	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	618381	15918353	43210630	426	8442											
CYP4F2	8529	broad.mit.edu	37	chr19	16001226	16001226	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcactaccctctgaggcCaggagctgccacttggccta	8	7	11	15	0	1	1	0	1	1	0	1	2	1	2	4	4	3	2	4	4	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:16001226C>T	uc002nbs.1	-	6	593	c.543G>A	c.(541-543)CTG>CTA	p.L181L	CYP4F2_uc010xot.1_Silent_p.L32L|CYP4F2_uc010xou.1_Silent_p.L32L	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	181					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CCTCTGAGGCCAGGAGCTGCC	0.557													30	32					0	0	0	0	T	16001226	T	T	16001226	2	4	39	1	0	0	0	0	0	0	0	1	4205	581	21	4		4	CYP4F2	19	16001226	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	82873	16001226	43127757	427	8443											
CPAMD8	27151	broad.mit.edu	37	chr19	17040011	17040011	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtggccgctgcacatacTggaactcatacttgttgggg	8	10	13	10	1	1	0	1	0	0	0	1	1	1	1	1	4	4	4	1	4	3	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:17040011T>C	uc002nfb.2	-	24	3058	c.3026A>G	c.(3025-3027)CAG>CGG	p.Q1009R		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	962						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CTGCACATACTGGAACTCATA	0.587													18	60					0	0	0	0	C	17040011	C	C	17040011	3	2	39	1	0	0	0	0	1	0	0	0	3810	1580	55	5	2848	5	CPAMD8	19	17040011	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	1038785	17040011	42088972	428	8444											
KIAA1683	80726	broad.mit.edu	37	chr19	18368706	18368706	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacagccggatcctgcgacGcgccaggtagccacggacgc	8	3	13	17	6	0	0	0	0	0	0	1	3	1	2	5	3	3	1	5	3	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:18368706G>A	uc002nin.2	-	4	3043	c.2827C>T	c.(2827-2829)CGT>TGT	p.R943C	PDE4C_uc002nil.3_5'Flank|KIAA1683_uc010ebn.2_Missense_Mutation_p.R1130C|KIAA1683_uc010xqe.1_Missense_Mutation_p.R897C|KIAA1683_uc010xqf.1_RNA	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	943	IQ 2.					mitochondrion				ovary(2)	2						ATCCTGCGACGCGCCAGGTAG	0.672													50	71					0	0	0	0	A	18368706	A	A	18368706	3	1	39	1	0	0	0	0	1	0	0	0	8290	1087	38	1	719	1	KIAA1683	19	18368706	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1328695	18368706	40760277	429	8445											
ZNF99	7652	broad.mit.edu	37	chr19	22940817	22940817	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttctaagggttgaggactGgctaaaagctttgccacatt	10	14	10	7	0	1	1	0	1	1	0	1	2	1	2	1	3	2	3	1	3	3	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:22940817G>A	uc010xrh.1	-	5	1621	c.1621C>T	c.(1621-1623)CAG>TAG	p.Q541*		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GTTGAGGACTGGCTAAAAGCT	0.388													38	69					0	0	0	0	A	22940817	A	A	22940817	4	1	39	1	0	0	0	0	0	1	0	0	18271	1357	47	4	1503	4	ZNF99	19	22940817	Nonsense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4572111	22940817	36188166	430	8446											
ANKRD27	84079	broad.mit.edu	37	chr19	33117730	33117730	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggtcgatgagggatgccTgccctgcagagcagaaggac	10	5	17	9	1	0	3	0	1	0	2	1	7	0	6	2	4	4	2	2	4	1	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:33117730T>G	uc002ntn.1	-	16	1580	c.1424A>C	c.(1423-1425)CAG>CCG	p.Q475P		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	475	ANK 2.				early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					GAGGGATGCCTGCCCTGCAGA	0.567													9	14					0	0	0	0	G	33117730	G	G	33117730	3	3	39	1	0	0	0	0	1	0	0	0	655	1580	55	5	1784	5	ANKRD27	19	33117730	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	10176913	33117730	26011253	431	8447											
NPHS1	4868	broad.mit.edu	37	chr19	36321757	36321757	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttctcaccatctgcacttCatcgtagaggggtccccagg	7	10	10	14	1	3	1	2	0	2	1	6	1	4	1	3	3	1	3	3	3	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:36321757C>T	uc002oby.2	-	28	3583	c.3583G>A	c.(3583-3585)GAA>AAA	p.E1195K		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	1195	Binds to NPHS2.|Cytoplasmic (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATCTGCACTTCATCGTAGAGG	0.468													51	187					0	0	0	0	T	36321757	T	T	36321757	3	4	39	1	0	0	0	0	1	0	0	0	10636	835	29	2	150	2	NPHS1	19	36321757	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3204027	36321757	22807226	432	8448											
PLEKHG2	64857	broad.mit.edu	37	chr19	39915308	39915308	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccagggtccagcggctgcaCctccacttccggagccaagc	7	6	11	17	2	0	0	0	0	0	0	4	1	4	1	6	3	4	2	6	3	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:39915308C>T	uc010xuz.1	+	19	3860	c.3535C>T	c.(3535-3537)CCT>TCT	p.P1179S	PLEKHG2_uc010xuy.1_Missense_Mutation_p.P1120S|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.P957S	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	1179	Pro-rich.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGCGGCTGCACCTCCACTTCC	0.572													41	233					0	0	0	0	T	39915308	T	T	39915308	3	4	39	1	0	0	0	0	1	0	0	0	12124	507	18	4	3605	4	PLEKHG2	19	39915308	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3593551	39915308	19213675	433	8449											
FCGBP	8857	broad.mit.edu	37	chr19	40362807	40362807	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccaggctgcggcacaggaagGctttgtcacccttttgcgcg	6	9	13	13	3	1	0	1	0	0	0	1	1	1	1	2	4	2	3	2	4	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:40362807G>T	uc002omp.3	-	32	15271	c.15263C>A	c.(15262-15264)GCC>GAC	p.A5088D		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5088						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCACAGGAAGGCTTTGTCACC	0.652													79	117					2.67039e-37	4.03106e-37	1	0	T	40362807	T	T	40362807	3	4	39	1	0	0	0	0	1	0	0	0	5810	1203	42	4	974	4	FCGBP	19	40362807	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	447499	40362807	18766176	434	8450											
SPTBN4	57731	broad.mit.edu	37	chr19	41009736	41009736	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtctggctcactgccccaGgacaactttgggtatgagct	7	11	12	11	0	2	1	1	1	1	0	2	2	2	2	2	3	3	3	2	3	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:41009736G>T	uc002ony.2	+	12	1449	c.1363_splice	c.e12-1	p.D455_splice	SPTBN4_uc002onx.2_Splice_Site_p.D455_splice|SPTBN4_uc002onz.2_Splice_Site_p.D455_splice	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform						actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CACTGCCCCAGGACAACTTTG	0.602													8	18					0.00307968	0.00320703	1	0	T	41009736	T	T	41009736	5	4	39	1	0	0	0	0	0	0	1	0	15187	1014	35	4	1404	4	SPTBN4	19	41009736	Splice_Site	SNP	G	TCGA-CN-4727-01A-01D-1434-08	646929	41009736	18119247	435	8451											
PSG8	440533	broad.mit.edu	37	chr19	43268276	43268276	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatgtaatgtaatggtagagGtccctgatttgccctttgta	9	15	11	6	0	0	2	0	1	0	1	1	3	1	2	2	2	1	4	2	2	4	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:43268276G>T	uc002ouo.2	-	2	320	c.222C>A	c.(220-222)GAC>GAA	p.D74E	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Missense_Mutation_p.D74E|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_5'UTR|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Missense_Mutation_p.D74E|PSG8_uc002oum.3_Missense_Mutation_p.D74E|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.D74E	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	74	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				AATGGTAGAGGTCCCTGATTT	0.423													189	574					8.44433e-94	1.33662e-93	1	0	T	43268276	T	T	43268276	3	4	39	1	0	0	0	0	1	0	0	0	12723	1252	44	4	1095	4	PSG8	19	43268276	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	2258540	43268276	15860707	436	8452											
ZNF224	7767	broad.mit.edu	37	chr19	44610618	44610618	+	Frame_Shift_Del	DEL	A	-	-																															tcaagagtggtccttccagcAaatctgggaaaaaattgcaa																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:44610618delA	uc002oyh.1	+	6	607	c.305delA	c.(304-306)CAAfs	p.Q102fs	uc002oyi.2_RNA	NM_013398	NP_037530	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	102					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				TCCTTCCAGCAAATCTGGGAA	0.418													---	---	---								-	44610618	-	-	44610618	7	5	39	1	0	1	0	1	0	0	0	0	17845	130	5	0	319	0	ZNF224	19	44610618	Frame_Shift_Del	DEL	A	TCGA-CN-4727-01A-01D-1434-08	1342342	44610618	14518365	437	8453											
SIX5	147912	broad.mit.edu	37	chr19	46268861	46268861	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccccctgcggtggccccCaggagcagcccctcagggtc	5	5	12	19	1	2	0	2	0	0	0	3	1	2	1	6	4	3	1	6	4	0	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:46268861C>A	uc002pdb.2	-	3	2513	c.2118G>T	c.(2116-2118)CTG>CTT	p.L706L	SIX5_uc002pdc.2_3'UTR	NM_175875	NP_787071	Q8N196	SIX5_HUMAN	SIX homeobox 5	706						cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00783)|GBM - Glioblastoma multiforme(486;0.0802)|Epithelial(262;0.235)		CGGTGGCCCCCAGGAGCAGCC	0.672													67	109					9.07738e-34	1.34462e-33	1	0	A	46268861	A	A	46268861	2	1	39	1	0	0	0	0	0	0	0	1	14415	581	21	4		4	SIX5	19	46268861	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1658243	46268861	12860122	438	8454											
GLTSCR1	29998	broad.mit.edu	37	chr19	48176835	48176835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caccccatccagtggcgatgGatgatgaggatgggagatgc	10	7	15	9	1	0	3	0	2	0	1	1	7	1	5	3	4	1	0	3	4	0	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:48176835G>A	uc002phh.3	+	3	198	c.4G>A	c.(4-6)GAT>AAT	p.D2N		NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	2							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		AGTGGCGATGGATGATGAGGA	0.438													32	124					0	0	0	0	A	48176835	A	A	48176835	3	1	39	1	0	0	0	0	1	0	0	0	6511	1174	41	2	6	2	GLTSCR1	19	48176835	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1907974	48176835	10952148	439	8455											
FPR2	2358	broad.mit.edu	37	chr19	52272482	52272482	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcacccctgaggagaggCtgaaggtggccattaccatg	9	7	15	10	0	0	3	0	2	0	1	0	4	0	3	4	5	1	2	4	5	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:52272482C>A	uc002pxr.2	+	2	616	c.571C>A	c.(571-573)CTG>ATG	p.L191M	FPR2_uc002pxs.3_Missense_Mutation_p.L191M|FPR2_uc010epf.2_Missense_Mutation_p.L191M	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	191	Extracellular (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						TGAGGAGAGGCTGAAGGTGGC	0.488													20	137					1.15919e-05	1.25183e-05	1	0	A	52272482	A	A	52272482	3	1	39	1	0	0	0	0	1	0	0	0	6073	796	28	4	573	4	FPR2	19	52272482	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4095647	52272482	6856501	440	8456											
NLRP8	126205	broad.mit.edu	37	chr19	56466176	56466176	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccaagaggtgaaccagaCgacagaccagagcttctccg	12	6	11	12	2	1	5	0	1	1	4	2	6	1	5	4	1	3	1	4	1	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:56466176C>T	uc002qmh.2	+	3	823	c.752C>T	c.(751-753)ACG>ATG	p.T251M	NLRP8_uc010etg.2_Missense_Mutation_p.T251M	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	251	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GTGAACCAGACGACAGACCAG	0.512													49	210					0	0	0	0	T	56466176	T	T	56466176	3	4	39	1	0	0	0	0	1	0	0	0	10537	536	19	1	762	1	NLRP8	19	56466176	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4193694	56466176	2662807	441	8457											
ZNF835	90485	broad.mit.edu	37	chr19	57176029	57176029	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcgccagtgggacgccaggtAcgagccctggctgaaggcct	7	5	16	13	3	0	1	0	1	0	0	0	3	0	2	4	4	2	2	4	4	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:57176029A>T	uc010ygo.1	-	2	604	c.604T>A	c.(604-606)TAC>AAC	p.Y202N	ZNF835_uc010ygn.1_Missense_Mutation_p.Y180N	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GACGCCAGGTACGAGCCCTGG	0.706													7	6					0	0	0	0	T	57176029	T	T	57176029	3	4	39	1	0	0	0	0	1	0	0	0	18253	391	14	5	1077	5	ZNF835	19	57176029	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	709853	57176029	1952954	442	8458											
PEG3	5178	broad.mit.edu	37	chr19	57327145	57327145	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagagtcttcatagttgcGattcttactgcccccttcac	8	13	7	13	1	4	1	2	0	2	1	4	3	4	1	2	0	3	1	2	0	2	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:57327145G>T	uc002qnu.2	-	7	3016	c.2665C>A	c.(2665-2667)CGC>AGC	p.R889S	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.R860S|PEG3_uc002qnv.2_Missense_Mutation_p.R889S|PEG3_uc002qnw.2_Missense_Mutation_p.R765S|PEG3_uc002qnx.2_Missense_Mutation_p.R763S|PEG3_uc010etr.2_Missense_Mutation_p.R889S	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	889					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCATAGTTGCGATTCTTACTG	0.443													26	128					3.7963e-18	5.08008e-18	1	0	T	57327145	T	T	57327145	3	4	39	1	0	0	0	0	1	0	0	0	11774	1058	37	3	2105	3	PEG3	19	57327145	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	151116	57327145	1801838	443	8459											
USP29	57663	broad.mit.edu	37	chr19	57642105	57642105	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcttcaagaggtgcctcaaCatccagaacttcagaagtat	14	10	7	10	0	4	3	3	0	1	3	5	3	5	3	2	1	3	1	2	1	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:57642105C>A	uc002qny.2	+	4	2418	c.2062C>A	c.(2062-2064)CAT>AAT	p.H688N		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	688					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGTGCCTCAACATCCAGAACT	0.433													15	58					7.93312e-07	8.65147e-07	1	0	A	57642105	A	A	57642105	3	1	39	1	0	0	0	0	1	0	0	0	17127	478	17	4	2064	4	USP29	19	57642105	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	314960	57642105	1486878	444	8460											
ZNF460	10794	broad.mit.edu	37	chr19	57803285	57803285	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgtgggaaagccttttgtcGgaccacaaacctgattcgac	11	10	10	10	2	0	1	0	1	0	0	2	4	0	3	3	2	2	0	3	2	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr19:57803285G>T	uc002qog.2	+	3	1698	c.1376G>T	c.(1375-1377)CGG>CTG	p.R459L	ZNF460_uc010ygv.1_Missense_Mutation_p.R418L	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	459	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCCTTTTGTCGGACCACAAAC	0.527													21	98					3.8784e-16	4.98523e-16	1	0	T	57803285	T	T	57803285	3	4	39	1	0	0	0	0	1	0	0	0	17991	1116	39	3	1386	3	ZNF460	19	57803285	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	161180	57803285	1325698	445	8461											
NRSN2	80023	broad.mit.edu	37	chr20	330327	330327	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttcctgcagctgcagccgcGgccccagcgtggaggatggc	5	6	16	14	3	0	0	0	0	0	0	1	2	1	2	4	4	5	4	4	4	0	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr20:330327G>T	uc002wdi.3	+	3	578	c.40G>T	c.(40-42)GGC>TGC	p.G14C	NRSN2_uc002wdj.2_Intron|NRSN2_uc002wdl.2_Missense_Mutation_p.G13C	NM_024958	NP_079234	Q9GZP1	NRSN2_HUMAN	neurensin 2	14						integral to membrane|plasma membrane|transport vesicle					0		all_cancers(10;0.0834)				CTGCAGCCGCGGCCCCAGCGT	0.632													27	48					3.93418e-24	5.56004e-24	1	0	T	330327	T	T	330327	3	4	39	1	0	0	0	0	1	0	0	0	10717	1116	39	3	42	3	NRSN2	20	330327	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08		330327	62695193	446	8462											
SIRPB1	10326	broad.mit.edu	37	chr20	1552462	1552462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttgagagtgaacgtcccCacgggtcagcaccaccctgg	9	6	12	14	2	1	2	1	2	0	1	2	4	2	2	4	2	2	1	4	2	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr20:1552462C>T	uc010gai.2	-	3	754	c.655G>A	c.(655-657)GGG>AGG	p.G219R	SIRPB1_uc002wfk.3_Intron	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	219	Ig-like C1-type 1.|Extracellular (Potential).				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						TGAACGTCCCCACGGGTCAGC	0.582													63	131					0	0	0	0	T	1552462	T	T	1552462	3	4	39	1	0	0	0	0	1	0	0	0	14398	594	21	4	553	4	SIRPB1	20	1552462	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	1222135	1552462	61473058	447	8463											
PDYN	5173	broad.mit.edu	37	chr20	1961152	1961152	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatggcccatgctatccccGtccccctccccagccacctc	5	8	5	23	1	1	0	1	0	0	0	5	0	4	0	9	1	2	1	9	1	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr20:1961152G>A	uc010gaj.2	-	3	824	c.582C>T	c.(580-582)GAC>GAT	p.D194D	uc002wfu.1_Intron|PDYN_uc002wfv.2_Silent_p.D194D|PDYN_uc010zpt.1_Silent_p.D39D	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	194					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						TGCTATCCCCGTCCCCCTCCC	0.592													93	158					0	0	0	0	A	1961152	A	A	1961152	2	1	39	1	0	0	0	0	0	0	0	1	11753	1136	40	1		1	PDYN	20	1961152	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	408690	1961152	61064368	448	8464											
PAK7	57144	broad.mit.edu	37	chr20	9561465	9561465	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggctccctgatctggggtgGgtgggctttctttccttagg	3	14	15	9	0	2	1	0	1	2	0	4	1	4	1	2	6	0	2	2	6	1	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr20:9561465G>A	uc002wnl.2	-	5	862	c.317C>T	c.(316-318)CCC>CTC	p.P106L	PAK7_uc002wnk.2_Missense_Mutation_p.P106L|PAK7_uc002wnj.2_Missense_Mutation_p.P106L|PAK7_uc010gby.1_Missense_Mutation_p.P106L	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	106	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ATCTGGGGTGGGTGGGCTTTC	0.542													127	185					0	0	0	0	A	9561465	A	A	9561465	3	1	39	1	0	0	0	0	1	0	0	0	11459	1232	43	4	1870	4	PAK7	20	9561465	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	7600313	9561465	53464055	449	8465											
MAFB	9935	broad.mit.edu	37	chr20	39317053	39317053	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtgggccacgccggcgccCgggtacgcgtggtgcgggtg	2	6	20	13	8	0	0	0	0	0	0	1	0	0	0	3	5	2	1	3	5	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr20:39317053C>A	uc002xji.2	-	1	824	c.438G>T	c.(436-438)CCG>CCT	p.P146P		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	146					negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				CGCCGGCGCCCGGGTACGCgt	0.587			T	IGH@	MM								13	14					2.62699e-14	3.30762e-14	1	0	A	39317053	A	A	39317053	2	1	39	1	0	0	0	0	0	0	0	1	9209	639	23	3		3	MAFB	20	39317053	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	29755588	39317053	23708467	450	8466											
ZNF831	128611	broad.mit.edu	37	chr20	57767409	57767409	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatcgacctgcccacgccCtacacctacaaggactcctt	10	7	6	18	2	0	0	0	0	0	0	2	2	1	1	5	1	4	1	5	1	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr20:57767409C>A	uc002yan.2	+	1	1335	c.1335C>A	c.(1333-1335)CCC>CCA	p.P445P		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	445						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TGCCCACGCCCTACACCTACA	0.682													15	71					7.93312e-07	8.65147e-07	1	0	A	57767409	A	A	57767409	2	1	39	1	0	0	0	0	0	0	0	1	18252	668	24	4		4	ZNF831	20	57767409	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	18450356	57767409	5258111	451	8467											
LAMA5	3911	broad.mit.edu	37	chr20	60905980	60905980	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctggggcggctttgggaagCgcgagggcagacaggcggca	7	4	21	9	4	0	1	0	0	0	1	0	3	0	2	0	7	1	4	0	7	1	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr20:60905980C>G	uc002ycq.2	-	30	3738	c.3671G>C	c.(3670-3672)CGC>CCC	p.R1224P		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1224	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTTTGGGAAGCGCGAGGGCAG	0.721													2	5					0	0	0	0	G	60905980	G	G	60905980	3	3	39	1	0	0	0	0	1	0	0	0	8649	768	27	3	7620	3	LAMA5	20	60905980	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3138571	60905980	2119540	452	8468											
TPTE	7179	broad.mit.edu	37	chr21	10944708	10944708	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttaatgtcaaaaaaaatgtAaacgacatcaaccagcagaa	21	7	5	8	1	2	1	2	0	0	1	2	2	2	1	1	0	3	2	1	0	9	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr21:10944708A>G	uc002yip.1	-	11	894	c.526T>C	c.(526-528)TAC>CAC	p.Y176H	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.Y158H|TPTE_uc002yir.1_Missense_Mutation_p.Y138H|TPTE_uc010gkv.1_Missense_Mutation_p.Y38H	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	176	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAAAAAATGTAAACGACATCA	0.294													27	308					0	0	0	0	G	10944708	G	G	10944708	3	3	39	1	0	0	0	0	1	0	0	0	16497	362	13	5	1185	5	TPTE	21	10944708	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08		10944708	37185187	453	8469											
HSPA13	6782	broad.mit.edu	37	chr21	15748099	15748099	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggagaccataggccatagCtgctgctgtgggttcattta	8	12	13	8	0	1	1	1	0	0	1	1	2	1	1	2	3	3	4	2	3	3	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr21:15748099C>A	uc002yjt.2	-	4	691	c.622G>T	c.(622-624)GCT>TCT	p.A208S	HSPA13_uc011abx.1_5'UTR	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	208						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						TAGGCCATAGCTGCTGCTGTG	0.443													50	94					1.63038e-21	2.2302e-21	1	0	A	15748099	A	A	15748099	3	1	39	1	0	0	0	0	1	0	0	0	7445	797	28	4	801	4	HSPA13	21	15748099	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4803391	15748099	32381796	454	8470											
SAMSN1	64092	broad.mit.edu	37	chr21	15870888	15870888	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttctagagtctcataaccaTtgagcaaaagtgttgaggtg	12	12	10	7	0	2	3	1	2	2	1	3	3	2	3	1	1	2	2	1	1	4	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr21:15870888T>C	uc002yju.1	-	7	876	c.794A>G	c.(793-795)AAT>AGT	p.N265S	SAMSN1_uc010gky.1_Missense_Mutation_p.N97S|SAMSN1_uc002yjv.1_Missense_Mutation_p.N333S	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	265	SAM.				negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CTCATAACCATTGAGCAAAAG	0.284													35	101					0	0	0	0	C	15870888	C	C	15870888	3	2	39	1	0	0	0	0	1	0	0	0	13895	1493	52	5	335	5	SAMSN1	21	15870888	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	122789	15870888	32259007	455	8471											
ADAMTS5	11096	broad.mit.edu	37	chr21	28338240	28338240	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtagcgcgcgtgcttgacCgcgaagaagccgtcgagacc	8	6	15	12	7	0	3	0	1	0	2	1	5	0	3	3	0	3	2	3	0	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr21:28338240C>A	uc002ymg.2	-	1	1200	c.471G>T	c.(469-471)GCG>GCT	p.A157A		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	157					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CGTGCTTGACCGCGAAGAAGC	0.662													9	44					0.00448238	0.00465899	1	0	A	28338240	A	A	28338240	2	1	39	1	0	0	0	0	0	0	0	1	269	639	23	3		3	ADAMTS5	21	28338240	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	12467352	28338240	19791655	456	8472											
RWDD2B	10069	broad.mit.edu	37	chr21	30391545	30391545	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gactcaccttgagccgtggcCccctcactgctgtaacccgg	6	8	10	17	2	2	1	2	1	0	0	2	2	2	1	5	2	3	2	5	2	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr21:30391545C>T	uc002yms.2	-	1	141	c.54G>A	c.(52-54)GGG>GGA	p.G18G	RWDD2B_uc002ymt.2_5'UTR|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_5'UTR	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	18											0						GAGCCGTGGCCCCCTCACTGC	0.582													4	9					0	0	0	0	T	30391545	T	T	30391545	2	4	39	1	0	0	0	0	0	0	0	1	13821	610	22	4		4	RWDD2B	21	30391545	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2053305	30391545	17738350	457	8473											
KRTAP21-1	337977	broad.mit.edu	37	chr21	32127484	32127484	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagaatagcatcttctaaaGcaaaatggccggtagccaca	16	7	9	9	1	2	1	0	0	2	1	2	2	2	1	2	2	3	3	2	2	8	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr21:32127484G>T	uc011adi.1	-	1	213	c.213C>A	c.(211-213)TGC>TGA	p.C71*		NM_181619	NP_853650	Q3LI58	KR211_HUMAN	keratin associated protein 21-1	71						intermediate filament				breast(1)	1						ATCTTCTAAAGCAAAATGGCC	0.299													37	205					2.48696e-23	3.47923e-23	1	0	T	32127484	T	T	32127484	4	4	39	1	0	0	0	0	0	1	0	0	8577	963	34	4	28	4	KRTAP21-1	21	32127484	Nonsense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1735939	32127484	16002411	458	8474											
DSCAM	1826	broad.mit.edu	37	chr21	41516604	41516604	+	Frame_Shift_Del	DEL	G	-	-																															acccccagtgctgtactctcGgtaacctatttggtagccac																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr21:41516604delG	uc002yyq.1	-	17	3525	c.3073delC	c.(3073-3075)CGAfs	p.R1025fs	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1025	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTGTACTCTCGGTAACCTATT	0.453													---	---	---								-	41516604	-	-	41516604	7	5	39	1	0	1	0	1	0	0	0	0	4790	1124	39	0	3033	0	DSCAM	21	41516604	Frame_Shift_Del	DEL	G	TCGA-CN-4727-01A-01D-1434-08	9389120	41516604	6613291	459	8475											
GAB4	128954	broad.mit.edu	37	chr22	17451084	17451084	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggagaagctggcactcCtaagagagagaaagaaggga	15	4	15	7	0	0	4	0	0	0	4	1	8	1	5	2	3	1	2	2	3	4	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr22:17451084C>G	uc002zlw.2	-	4	795	c.687_splice	c.e4-1	p.R229_splice	GAB4_uc010gqs.1_Intron	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member											large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GCTGGCACTCCTAAGAGAGAG	0.532													24	82					0	0	0	0	G	17451084	G	G	17451084	5	3	39	1	0	0	0	0	0	0	1	0	6185	695	24	4	1066	4	GAB4	22	17451084	Splice_Site	SNP	C	TCGA-CN-4727-01A-01D-1434-08		17451084	33853482	460	8476											
DGCR14	8220	broad.mit.edu	37	chr22	19127505	19127505	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagacatctaggctgggcaGcggctccttctcctcctcct	6	10	10	15	1	2	1	0	0	2	1	6	2	5	1	4	3	1	3	4	3	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr22:19127505G>A	uc002zou.2	-	4	470	c.433C>T	c.(433-435)CTG>TTG	p.L145L	DGCR14_uc002zot.2_Silent_p.L66L|DGCR14_uc002zov.2_RNA	NM_022719	NP_073210	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region protein 14	145					nervous system development	catalytic step 2 spliceosome				ovary(1)	1	Colorectal(54;0.0993)					AGGCTGGGCAGCGGCTCCTTC	0.612													85	131					0	0	0	0	A	19127505	A	A	19127505	2	1	39	1	0	0	0	0	0	0	0	1	4482	962	34	4		4	DGCR14	22	19127505	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	1676421	19127505	32177061	461	8477											
FBXO7	25793	broad.mit.edu	37	chr22	32889195	32889195	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccgtcttgtctttgtctgcGgtttgtcgtgacctctttac	2	19	9	11	3	4	1	0	1	4	0	6	1	5	1	2	1	2	1	2	1	1	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr22:32889195G>C	uc003amq.2	+	7	1354	c.1071G>C	c.(1069-1071)GCG>GCC	p.A357A	FBXO7_uc003amr.2_Silent_p.A243A|FBXO7_uc003ams.2_Silent_p.A201A|FBXO7_uc003amt.2_Silent_p.A278A|FBXO7_uc003amu.2_Silent_p.A243A|FBXO7_uc003amv.2_Silent_p.A56A	NM_012179	NP_036311	Q9Y3I1	FBX7_HUMAN	F-box only protein 7 isoform 1	357	F-box.				cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						CTTTGTCTGCGGTTTGTCGTG	0.448													89	187					0	0	0	0	C	32889195	C	C	32889195	2	2	39	1	0	0	0	0	0	0	0	1	5792	1103	39	3		3	FBXO7	22	32889195	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	13761690	32889195	18415371	462	8478											
NCF4	4689	broad.mit.edu	37	chr22	37266473	37266473	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagagcctgctcagcctgcCggtctgggtgctgatggatg	6	9	15	11	1	2	2	1	1	1	1	2	3	2	3	3	3	5	2	3	3	0	0			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr22:37266473C>G	uc003apy.3	+	5	543	c.359C>G	c.(358-360)CCG>CGG	p.P120R	NCF4_uc003apz.3_Missense_Mutation_p.P120R	NM_000631	NP_000622	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4 isoform 1	120	PX.				cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			ovary(1)	1						CTCAGCCTGCCGGTCTGGGTG	0.642													30	89					0	0	0	0	G	37266473	G	G	37266473	3	3	39	1	0	0	0	0	1	0	0	0	10272	652	23	3	377	3	NCF4	22	37266473	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	4377278	37266473	14038093	463	8479											
SMC1B	27127	broad.mit.edu	37	chr22	45779421	45779421	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcccagcatctagcctTgtattttaagtcacttgacc	9	14	5	13	0	3	1	2	1	1	0	4	1	4	1	3	0	2	2	3	0	3	6			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr22:45779421T>C	uc003bgc.2	-	12	2036	c.1984A>G	c.(1984-1986)AAG>GAG	p.K662E	SMC1B_uc003bgd.2_Missense_Mutation_p.K662E|SMC1B_uc003bge.1_Missense_Mutation_p.K445E	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	662	Flexible hinge.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CATCTAGCCTTGTATTTTAAG	0.363													67	108					0	0	0	0	C	45779421	C	C	45779421	3	2	39	1	0	0	0	0	1	0	0	0	14846	1821	63	5	1779	5	SMC1B	22	45779421	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	8512948	45779421	5525145	464	8480											
MOV10L1	54456	broad.mit.edu	37	chr22	50552123	50552123	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcatttctatggaacgattTtgctgaagaacaaaggtgat	13	13	9	6	1	2	3	1	2	1	1	2	5	2	4	0	2	3	1	0	2	5	4			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chr22:50552123T>G	uc003bjj.2	+	6	873	c.790T>G	c.(790-792)TTG>GTG	p.L264V	MOV10L1_uc003bjk.3_Missense_Mutation_p.L264V|MOV10L1_uc011arp.1_Missense_Mutation_p.L244V|MOV10L1_uc011arq.1_Missense_Mutation_p.L25V|MOV10L1_uc010hao.1_5'Flank	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	264					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TGGAACGATTTTGCTGAAGAA	0.473													47	115					0	0	0	0	G	50552123	G	G	50552123	3	3	39	1	0	0	0	0	1	0	0	0	9772	1838	64	5	853	5	MOV10L1	22	50552123	Missense_Mutation	SNP	T	TCGA-CN-4727-01A-01D-1434-08	4772702	50552123	752443	465	8481											
DDX53	168400	broad.mit.edu	37	chrX	23019337	23019337	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctggatatggaatttgaacCccagataaggaagattttat	14	12	10	5	0	0	3	0	1	0	2	0	6	0	6	2	3	1	1	2	3	6	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:23019337C>T	uc004daj.2	+	1	1251	c.1163C>T	c.(1162-1164)CCC>CTC	p.P388L		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	388	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						GAATTTGAACCCCAGATAAGG	0.403													44	84					0	0	0	0	T	23019337	T	T	23019337	3	4	39	1	0	0	0	0	1	0	0	0	4388	623	22	4	1165	4	DDX53	23	23019337	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08		23019337	132251223	466	8482											
MAGEB18	286514	broad.mit.edu	37	chrX	26157130	26157130	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtcagaagagtaagctcCgtgcccgtgagaaacgccac	12	5	13	11	3	1	3	1	1	0	3	2	5	2	3	3	1	3	2	3	1	3	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:26157130C>A	uc004dbq.1	+	2	215	c.28C>A	c.(28-30)CGT>AGT	p.R10S		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	10							protein binding			central_nervous_system(1)	1						GAGTAAGCTCCGTGCCCGTGA	0.542													8	8					5.4927e-09	6.32632e-09	1	0	A	26157130	A	A	26157130	3	1	39	1	0	0	0	0	1	0	0	0	9228	652	23	3	30	3	MAGEB18	23	26157130	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3137793	26157130	129113430	467	8483											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29938141	29938141	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgtggaagaaggtgacttGggaaattactcctgttatgt	10	14	12	5	0	1	2	0	1	1	1	2	4	2	4	1	3	1	1	1	3	5	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:29938141G>T	uc004dby.2	+	8	1495	c.987G>T	c.(985-987)TTG>TTT	p.L329F		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	329	Extracellular (Potential).|Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						AAGGTGACTTGGGAAATTACT	0.418													48	38					1.61863e-15	2.06617e-15	1	0	T	29938141	T	T	29938141	3	4	39	1	0	0	0	0	1	0	0	0	7700	1339	47	4	1013	4	IL1RAPL1	23	29938141	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	3781011	29938141	125332419	468	8484											
NR0B1	190	broad.mit.edu	37	chrX	30326412	30326412	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcacttgatggcttggacctGggaggcggagggcaccttcc	6	8	16	11	1	0	1	0	1	0	0	1	4	1	4	3	6	0	3	3	6	0	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:30326412G>T	uc004dcf.3	-	1	1084	c.1069C>A	c.(1069-1071)CAG>AAG	p.Q357K		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	357	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	GCTTGGACCTGGGAGGCGGAG	0.637											OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	26					2.70639e-06	2.93413e-06	1	0	T	30326412	T	T	30326412	3	4	39	1	0	0	0	0	1	0	0	0	10667	1357	47	4	351	4	NR0B1	23	30326412	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	388271	30326412	124944148	469	8485											
ELK1	2002	broad.mit.edu	37	chrX	47497248	47497248	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccgttcgggtcccggccCacctagcaggctcgggctga	4	7	15	15	4	0	1	0	1	0	0	4	1	2	1	4	5	1	4	4	5	1	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:47497248C>A	uc004dik.3	-	5	1310	c.988G>T	c.(988-990)GGG>TGG	p.G330W	ELK1_uc010nhv.2_Missense_Mutation_p.G330W|ELK1_uc010nhw.2_Missense_Mutation_p.G220W|ELK1_uc004dil.3_Intron	NM_001114123	NP_001107595	P19419	ELK1_HUMAN	ELK1 protein	330					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						GGTCCCGGCCCACCTAGCAGG	0.701													3	2					0.004672	0.0048289	1	0	A	47497248	A	A	47497248	3	1	39	1	0	0	0	0	1	0	0	0	5083	594	21	4	310	4	ELK1	23	47497248	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	17170836	47497248	107773312	470	8486											
GSPT2	23708	broad.mit.edu	37	chrX	51488354	51488354	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttataatgcggtgctgcaCattcatacttgtattgagga	10	14	11	6	1	1	1	1	1	0	0	1	2	1	2	0	3	4	4	0	3	4	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:51488354C>A	uc004dpl.2	+	1	1858	c.1632C>A	c.(1630-1632)CAC>CAA	p.H544Q		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	544					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					CGGTGCTGCACATTCATACTT	0.423													47	47					2.01872e-29	2.91242e-29	1	0	A	51488354	A	A	51488354	3	1	39	1	0	0	0	0	1	0	0	0	6866	477	17	4	1634	4	GSPT2	23	51488354	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	3991106	51488354	103782206	471	8487											
KLF8	11279	broad.mit.edu	37	chrX	56296753	56296753	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcaccgcagaatccatacAggtctgcccactcccatctc	9	8	6	18	1	3	1	1	0	2	1	6	1	5	1	4	1	2	2	4	1	2	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:56296753A>T	uc004dur.2	+	5	1843	c.897A>T	c.(895-897)ACA>ACT	p.T299T	KLF8_uc011mop.1_Intron|KLF8_uc010nkh.2_RNA	NM_007250	NP_009181	O95600	KLF8_HUMAN	Kruppel-like factor 8 isoform 1	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAATCCATACAGGTCTGCCCA	0.318													9	6					0	0	0	0	T	56296753	T	T	56296753	2	4	39	1	0	0	0	0	0	0	0	1	8391	202	7	5		5	KLF8	23	56296753	Silent	SNP	A	TCGA-CN-4727-01A-01D-1434-08	4808399	56296753	98973807	472	8488											
CYLC1	1538	broad.mit.edu	37	chrX	83128538	83128538	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactcacagaataattcaaaGaattattctttgaagtatac	17	14	4	6	0	3	3	2	1	1	2	3	3	3	3	0	0	2	1	0	0	9	8	rs148140928		TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:83128538G>A	uc004eei.1	+	4	843	c.822G>A	c.(820-822)AAG>AAA	p.K274K	CYLC1_uc004eeh.1_Silent_p.K273K	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	274					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						ATAATTCAAAGAATTATTCTT	0.318													6	17					0	0	0	0	A	83128538	A	A	83128538	2	1	39	1	0	0	0	0	0	0	0	1	4158	933	33	2		2	CYLC1	23	83128538	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	26831785	83128538	72142022	473	8489											
RPS6KA6	27330	broad.mit.edu	37	chrX	83351277	83351277	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcctatacgcagcagtatCtcttcaggagtatcattggg	9	13	10	9	1	3	0	2	0	1	0	4	1	3	1	1	2	3	4	1	2	4	7			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:83351277C>T	uc004eej.1	-	20	1973	c.1896G>A	c.(1894-1896)GAG>GAA	p.E632E	RPS6KA6_uc011mqt.1_Silent_p.E632E|RPS6KA6_uc011mqu.1_Silent_p.E529E	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	632	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						GCAGCAGTATCTCTTCAGGAG	0.358													21	20					0	0	0	0	T	83351277	T	T	83351277	2	4	39	1	0	0	0	0	0	0	0	1	13720	912	32	2		2	RPS6KA6	23	83351277	Silent	SNP	C	TCGA-CN-4727-01A-01D-1434-08	222739	83351277	71919283	474	8490											
IL1RAPL2	26280	broad.mit.edu	37	chrX	105011320	105011320	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctggactccgcagaacaagGactttttggagaactccagc	11	9	10	11	1	1	2	0	0	1	2	3	5	3	4	2	3	3	1	2	3	3	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:105011320G>T	uc004elz.1	+	11	2483	c.1727G>T	c.(1726-1728)GGA>GTA	p.G576V		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	576	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						GCAGAACAAGGACTTTTTGGA	0.438													29	38					7.38237e-10	8.64658e-10	1	0	T	105011320	T	T	105011320	3	4	39	1	0	0	0	0	1	0	0	0	7701	1174	41	2	1765	2	IL1RAPL2	23	105011320	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	21660043	105011320	50259240	475	8491											
CXorf57	55086	broad.mit.edu	37	chrX	105855463	105855463	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggatccaaaaggttcttgaGcagattatggactcacctcg	11	11	10	9	1	2	2	1	1	1	1	4	4	3	4	2	3	1	2	2	3	3	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:105855463G>A	uc004emi.3	+	1	304	c.153G>A	c.(151-153)GAG>GAA	p.E51E	CXorf57_uc004emj.3_Silent_p.E51E|CXorf57_uc004emh.2_Silent_p.E51E	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	51										ovary(1)|lung(1)|breast(1)	3						AGGTTCTTGAGCAGATTATGG	0.607													48	43					0	0	0	0	A	105855463	A	A	105855463	2	1	39	1	0	0	0	0	0	0	0	1	4130	962	34	4		4	CXorf57	23	105855463	Silent	SNP	G	TCGA-CN-4727-01A-01D-1434-08	844143	105855463	49415097	476	8492											
UPF3B	65109	broad.mit.edu	37	chrX	118979179	118979180	+	Frame_Shift_Ins	INS	-	T	T																															ccatcatcgatagtcccgacINStttggtatctcttttcttag																										TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:118979179_118979180insT	uc004erz.1	-	4	527_528	c.450_451insA	c.(448-453)AAAGTCfs	p.K150fs	UPF3B_uc004esa.1_Frame_Shift_Ins_p.K150fs	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	150_151	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						ATAGTCCCGACTTTGGTATCTC	0.342													---	---	---								T	118979180	T	T	118979179	7	5	39	1	0	1	1	0	0	0	0	0	17074	565	20	0	1032	0	UPF3B	23	118979179	Frame_Shift_Ins	INS	-	TCGA-CN-4727-01A-01D-1434-08	13123716	118979179	36291381	477	8493											
STAG2	10735	broad.mit.edu	37	chrX	123217393	123217393	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actacttcgacaagacaaaaGaacagtgtatgtatttgctg	15	11	8	7	1	0	2	0	0	0	2	1	3	0	2	0	0	3	3	0	0	7	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:123217393G>A	uc004etz.3	+	28	3386	c.3047G>A	c.(3046-3048)AGA>AAA	p.R1016K	STAG2_uc004eua.2_Missense_Mutation_p.R1016K|STAG2_uc004eub.2_Missense_Mutation_p.R1016K|STAG2_uc004euc.2_Missense_Mutation_p.R1016K|STAG2_uc004eud.2_Missense_Mutation_p.R1016K|STAG2_uc004eue.2_Missense_Mutation_p.R1016K	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	1016					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CAAGACAAAAGAACAGTGTAT	0.358													25	30					0	0	0	0	A	123217393	A	A	123217393	3	1	39	1	0	0	0	0	1	0	0	0	15309	942	33	2	3153	2	STAG2	23	123217393	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	4238214	123217393	32053167	478	8494											
SLITRK4	139065	broad.mit.edu	37	chrX	142717166	142717166	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcttgtgaatggtgcagacgGcttatttaaaagtttgggac	10	13	13	5	1	0	2	0	1	0	1	0	3	0	3	0	3	1	4	0	3	4	5			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:142717166G>T	uc004fbx.2	-	2	2135	c.1759C>A	c.(1759-1761)CCG>ACG	p.P587T	SLITRK4_uc004fby.2_Missense_Mutation_p.P587T	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	587	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GGTGCAGACGGCTTATTTAAA	0.453													37	47					2.09667e-21	2.86097e-21	1	0	T	142717166	T	T	142717166	3	4	39	1	0	0	0	0	1	0	0	0	14809	1203	42	4	758	4	SLITRK4	23	142717166	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	19499773	142717166	12553394	479	8495											
SLITRK2	84631	broad.mit.edu	37	chrX	144905021	144905021	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtctgaatgtaaactgcCaagaaaggaagttcactaat	16	10	9	6	0	2	2	1	1	1	1	2	3	2	3	1	2	2	2	1	2	7	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:144905021C>G	uc004fcd.2	+	5	2068	c.1078C>G	c.(1078-1080)CAA>GAA	p.Q360E	SLITRK2_uc010nsp.2_Missense_Mutation_p.Q360E|SLITRK2_uc010nso.2_Missense_Mutation_p.Q360E|SLITRK2_uc011mwq.1_Missense_Mutation_p.Q360E|SLITRK2_uc011mwr.1_Missense_Mutation_p.Q360E|SLITRK2_uc011mws.1_Missense_Mutation_p.Q360E|SLITRK2_uc004fcg.2_Missense_Mutation_p.Q360E|SLITRK2_uc011mwt.1_Missense_Mutation_p.Q360E	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	360	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TGTAAACTGCCAAGAAAGGAA	0.473													31	22					0	0	0	0	G	144905021	G	G	144905021	3	3	39	1	0	0	0	0	1	0	0	0	14807	595	21	4	1080	4	SLITRK2	23	144905021	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2187855	144905021	10365539	480	8496											
PNMA3	29944	broad.mit.edu	37	chrX	152225666	152225666	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccaagggaaataccaggaaAgggggggccctgggaagtga	13	3	17	8	0	0	1	0	1	0	0	0	4	0	4	3	6	1	0	3	6	5	1			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:152225666A>G	uc004fhc.2	+	2	590	c.254A>G	c.(253-255)AAG>AGG	p.K85R	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	85					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ataccaggaaagggggggccc	0													13	23					0	0	0	0	G	152225666	G	G	152225666	3	3	39	1	0	0	0	0	1	0	0	0	12210	72	3	5	256	5	PNMA3	23	152225666	Missense_Mutation	SNP	A	TCGA-CN-4727-01A-01D-1434-08	7320645	152225666	3044894	481	8497											
SPRY3	10251	broad.mit.edu	37	chrX	155004162	155004162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agacaactgtgctgatgagcCctgctcttgtgggcctagtt	7	12	12	10	0	1	3	0	2	1	1	1	3	1	3	2	1	4	3	2	1	2	3			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:155004162C>T	uc004fnq.1	+	2	1083	c.629C>T	c.(628-630)CCC>CTC	p.P210L	SPRY3_uc010nvl.1_Missense_Mutation_p.P111L	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	210	SPR.|Cys-rich.				multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCTGATGAGCCCTGCTCTTGT	0.562													90	198					0	0	0	0	T	155004162	T	T	155004162	3	4	39	1	0	0	0	0	1	0	0	0	15173	623	22	4	631	4	SPRY3	23	155004162	Missense_Mutation	SNP	C	TCGA-CN-4727-01A-01D-1434-08	2778496	155004162	266398	482	8498											
IL9R	3581	broad.mit.edu	37	chrX	155233355	155233355	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttccagcaaccaggctcctGgcggcacacataagtgcatc	10	8	9	14	1	0	0	0	0	0	0	3	0	2	0	3	3	3	4	3	3	2	2			TCGA-CN-4727-01A-01D-1434-08	TCGA-CN-4727-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	b24fc60a-fe83-4743-a6d3-d90b807412e1	53489efb-ec71-4932-9980-aaacd8347b17	g.chrX:155233355G>A	uc004fnv.1	+	4	447	c.268G>A	c.(268-270)GGC>AGC	p.G90S	IL9R_uc010nvn.2_Missense_Mutation_p.G69S|IL9R_uc004fnu.1_Silent_p.L134L	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	90	Extracellular (Potential).				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCAGGCTCCTGGCGGCACACA	0.577													7	18					0	0	0	0	A	155233355	A	A	155233355	3	1	39	1	0	0	0	0	1	0	0	0	7747	1348	47	4	282	4	IL9R	23	155233355	Missense_Mutation	SNP	G	TCGA-CN-4727-01A-01D-1434-08	229193	155233355	37205	483	8499											
SLC2A5	6518	broad.mit.edu	37	chr1	9129568	9129568	+	Frame_Shift_Del	DEL	C	-	-																															gagcaacacactcaccccttCcttcatgctctgatcctgtt																										TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:9129568delC	uc001apo.2	-	1	320	c.28delG	c.(28-30)GAAfs	p.E10fs	SLC2A5_uc010nzz.1_5'UTR|SLC2A5_uc010oaa.1_5'UTR|SLC2A5_uc010oab.1_Frame_Shift_Del_p.E10fs|SLC2A5_uc010oac.1_Frame_Shift_Del_p.E10fs|SLC2A5_uc001app.3_Frame_Shift_Del_p.E10fs	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	10	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CTCACCCCTTCCTTCATGCTC	0.587													---	---	---								-	9129568	-	-	9129568	7	5	40	1	0	1	0	1	0	0	0	0	14612	864	30	0	1689	0	SLC2A5	1	9129568	Frame_Shift_Del	DEL	C	TCGA-CN-4728-01A-01D-1434-08		9129568	240121053	1	8500											
ZC3H12A	80149	broad.mit.edu	37	chr1	37949128	37949128	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgcacctggtggaggctgtGatggggcgcttcccacagct	5	8	15	13	2	0	1	0	1	0	0	1	2	1	2	3	5	1	4	3	5	0	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:37949128G>C	uc001cbb.3	+	6	1866	c.1716G>C	c.(1714-1716)GTG>GTC	p.V572V	ZC3H12A_uc001cbc.1_Silent_p.V367V	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	572					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGAGGCTGTGATGGGGCGCT	0.657													8	46					0	0	0	0	C	37949128	C	C	37949128	2	2	40	1	0	0	0	0	0	0	0	1	17628	1277	45	2		2	ZC3H12A	1	37949128	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	28819560	37949128	211301493	2	8501											
KNCN	148930	broad.mit.edu	37	chr1	47016763	47016763	+	5'Flank	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcagcgccaataaagacaCcgcccatggcagctgcagcc	12	3	10	16	2	0	1	0	0	0	1	0	1	0	1	4	1	5	4	4	1	3	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:47016763C>G	uc001cpy.2	-						KNCN_uc009vyh.1_Missense_Mutation_p.G42A			A6PVL3	KNCN_HUMAN	SubName: Full=cDNA FLJ32011 fis, clone NT2RP7009507;							integral to membrane					0	Acute lymphoblastic leukemia(166;0.155)					AATAAAGACACCGCCCATGGC	0.632													7	110					0	0	0	0	G	47016763	G	G	47016763	1	3	40	0	1	0	0	0	0	0	0	0	8464	507	18	4		4	KNCN	1	47016763	5'Flank	SNP	C	TCGA-CN-4728-01A-01D-1434-08	9067635	47016763	202233858	3	8502											
CYP4A22	284541	broad.mit.edu	37	chr1	47610609	47610609	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagagagctcagcactcccGtcaccttccctgatgggcgc	8	7	11	15	2	2	2	2	1	0	1	4	4	4	2	3	1	2	2	3	1	1	1	rs141856283		TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:47610609G>A	uc001cqv.1	+	9	1240	c.1189G>A	c.(1189-1191)GTC>ATC	p.V397I	CYP4A22_uc009vyo.2_Missense_Mutation_p.V397I|CYP4A22_uc009vyp.2_Missense_Mutation_p.V299I	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	397						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						CAGCACTCCCGTCACCTTCCC	0.582													7	58					0	0	0	0	A	47610609	A	A	47610609	3	1	40	1	0	0	0	0	1	0	0	0	4201	1145	40	1	1223	1	CYP4A22	1	47610609	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	593846	47610609	201640012	4	8503											
CACHD1	57685	broad.mit.edu	37	chr1	65099811	65099811	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttgtctccagccaccagtGagacaaaaaggaaaatgtcc	14	8	8	11	0	2	1	0	1	2	1	4	3	3	2	4	1	1	0	4	1	4	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:65099811G>A	uc001dbo.1	+	7	826	c.721G>A	c.(721-723)GAG>AAG	p.E241K	CACHD1_uc001dbp.1_5'UTR|CACHD1_uc001dbq.1_5'UTR	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	292	Extracellular (Potential).|VWFA.				calcium ion transport	integral to membrane				ovary(2)	2						AGCCACCAGTGAGACAAAAAG	0.473													7	70					0	0	0	0	A	65099811	A	A	65099811	3	1	40	1	0	0	0	0	1	0	0	0	2549	1291	45	2	747	2	CACHD1	1	65099811	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	17489202	65099811	184150810	5	8504											
PDE4B	5142	broad.mit.edu	37	chr1	66833700	66833700	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atggtagaaacgaagaaagtTacaagttcaggcgttcttct	14	11	10	6	2	3	2	1	0	2	2	3	3	3	2	0	2	2	4	0	2	6	5			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:66833700T>C	uc001dcn.2	+	15	1805	c.1614T>C	c.(1612-1614)GTT>GTC	p.V538V	PDE4B_uc009war.2_Silent_p.V446V|PDE4B_uc001dco.2_Silent_p.V538V|PDE4B_uc001dcp.2_Silent_p.V523V|PDE4B_uc001dcq.2_Silent_p.V366V|PDE4B_uc009was.2_Silent_p.V305V	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	538					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	CGAAGAAAGTTACAAGTTCAG	0.388													12	90					0	0	0	0	C	66833700	C	C	66833700	2	2	40	1	0	0	0	0	0	0	0	1	11694	1741	61	5		5	PDE4B	1	66833700	Silent	SNP	T	TCGA-CN-4728-01A-01D-1434-08	1733889	66833700	182416921	6	8505											
COL11A1	1301	broad.mit.edu	37	chr1	103355090	103355090	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccttgttctcctggaggaCcaatcaggccaattaaacca	11	9	7	14	0	2	0	1	0	1	0	3	2	2	2	6	3	1	1	6	3	4	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:103355090C>G	uc001dul.2	-	59	4703	c.4385G>C	c.(4384-4386)GGT>GCT	p.G1462A	COL11A1_uc001duk.2_Missense_Mutation_p.G658A|COL11A1_uc001dum.2_Missense_Mutation_p.G1474A|COL11A1_uc001dun.2_Missense_Mutation_p.G1423A|COL11A1_uc009weh.2_Missense_Mutation_p.G1346A	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1462	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCCTGGAGGACCAATCAGGCC	0.388													14	156					0	0	0	0	G	103355090	G	G	103355090	3	3	40	1	0	0	0	0	1	0	0	0	3682	507	18	4	1071	4	COL11A1	1	103355090	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	36521390	103355090	145895531	7	8506											
KCNA3	3738	broad.mit.edu	37	chr1	111216803	111216803	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggaagtcgcggcggggcaagGgccgctcctcctcccgcagg	5	4	17	15	5	0	0	0	0	0	0	4	1	3	1	4	6	0	3	4	6	2	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:111216803G>A	uc001dzv.1	-	1	853	c.629C>T	c.(628-630)CCC>CTC	p.P210L		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	210						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCGGGGCAAGGGCCGCTCCTC	0.677													4	55					0	0	0	0	A	111216803	A	A	111216803	3	1	40	1	0	0	0	0	1	0	0	0	8043	1232	43	4	1102	4	KCNA3	1	111216803	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	7861713	111216803	138033818	8	8507											
PTGFRN	5738	broad.mit.edu	37	chr1	117487601	117487601	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agtgtcccgggctctgtctgCcgaccagggctcctacaggt	5	9	13	14	2	2	0	0	0	2	0	4	1	4	0	4	3	2	2	4	3	1	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:117487601C>T	uc001egv.1	+	3	856	c.719C>T	c.(718-720)GCC>GTC	p.A240V		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	240	Ig-like C2-type 2.|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GCTCTGTCTGCCGACCAGGGC	0.657													3	55					0	0	0	0	T	117487601	T	T	117487601	3	4	40	1	0	0	0	0	1	0	0	0	12813	739	26	4	729	4	PTGFRN	1	117487601	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	6270798	117487601	131763020	9	8508											
NBPF7	343505	broad.mit.edu	37	chr1	120378772	120378772	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catggtcactacaagaagtcGtaaccctttcctccggggag	10	9	10	12	2	1	1	1	0	0	1	4	2	3	2	3	3	2	1	3	3	4	3	rs76727176	byFrequency	TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:120378772G>A	uc010oxk.1	-	7	1595	c.974C>T	c.(973-975)ACG>ATG	p.T325M		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	325	NBPF 2.					cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		ACAAGAAGTCGTAACCCTTTC	0.488													4	85					0	0	0	0	A	120378772	A	A	120378772	3	1	40	1	0	0	0	0	1	0	0	0	10252	1145	40	1	298	1	NBPF7	1	120378772	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	2891171	120378772	128871849	10	8509											
PDE4DIP	9659	broad.mit.edu	37	chr1	144952292	144952292	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggtgactcccttcagttTctctgagagctccaggttac	6	15	9	11	0	2	2	1	2	1	1	5	3	4	2	2	2	2	3	2	2	1	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:144952292T>C	uc001elw.3	-	4	718	c.427A>G	c.(427-429)AAA>GAA	p.K143E	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.K209E|PDE4DIP_uc001emc.1_Missense_Mutation_p.K143E|PDE4DIP_uc001emd.1_Missense_Mutation_p.K143E|PDE4DIP_uc001emg.1_Missense_Mutation_p.K143E|PDE4DIP_uc001emh.2_Missense_Mutation_p.K280E	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	143					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CCCTTCAGTTTCTCTGAGAGC	0.532			T	PDGFRB	MPD								3	122					0	0	0	0	C	144952292	C	C	144952292	3	2	40	1	0	0	0	0	1	0	0	0	11697	1792	62	5	7920	5	PDE4DIP	1	144952292	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	24573520	144952292	104298329	11	8510											
TUFT1	7286	broad.mit.edu	37	chr1	151512818	151512818	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcggggtggacaagtggcGtgtgtgctgcgaccccgagg	6	6	19	10	4	0	0	0	0	0	0	0	3	0	1	2	5	3	1	2	5	1	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:151512818G>A	uc001eyl.2	+	1	38	c.-24G>A	c.(-26--22)GCGTG>GCATG		TUFT1_uc001eym.2_Translation_Start_Site|TUFT1_uc010pdf.1_Translation_Start_Site|TUFT1_uc010pdg.1_Translation_Start_Site	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1						bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GACAAGTGGCGTGTGTGCTGC	0.672											OREG0003907	type=REGULATORY REGION|Gene=TUFT1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	21	92					0	0	0	0	A	151512818	A	A	151512818	1	1	40	1	0	0	0	0	0	0	0	0	16840	1160	40	1		1	TUFT1	1	151512818	Translation_Start_Site	SNP	G	TCGA-CN-4728-01A-01D-1434-08	6560526	151512818	97737803	12	8511											
NES	10763	broad.mit.edu	37	chr1	156640663	156640663	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcctgggtcccccagccctCccaccccctgccccgggcct	2	5	10	24	1	0	0	0	0	0	0	2	0	2	0	10	3	2	0	10	3	0	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:156640663C>A	uc001fpq.2	-	4	3450	c.3317G>T	c.(3316-3318)GGA>GTA	p.G1106V		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1106	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCCCAGCCCTCCCACCCCCTG	0.657													12	62					1.5842e-08	1.86096e-08	1	0	A	156640663	A	A	156640663	3	1	40	1	0	0	0	0	1	0	0	0	10391	855	30	2	1552	2	NES	1	156640663	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	5127845	156640663	92609958	13	8512											
DARC	2532	broad.mit.edu	37	chr1	159176142	159176142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctacgcccctgctcctcGccctattctgccaccaggcc	4	9	8	20	2	1	0	0	0	1	0	3	0	2	0	7	2	3	2	7	2	2	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:159176142G>A	uc001fto.2	+	2	1153	c.913G>A	c.(913-915)GCC>ACC	p.A305T	DARC_uc001ftp.3_Missense_Mutation_p.A307T	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	305	Helical; Name=7; (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					CCTGCTCCTCGCCCTATTCTG	0.592													97	539					0	0	0	0	A	159176142	A	A	159176142	3	1	40	1	0	0	0	0	1	0	0	0	4257	1087	38	1	946	1	DARC	1	159176142	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	2535479	159176142	90074479	14	8513											
TOR3A	64222	broad.mit.edu	37	chr1	179064256	179064256	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaagagacactggatgaaaTagcccagatgatggtgtatg	15	8	13	5	0	0	5	0	2	0	3	0	7	0	6	1	2	1	1	1	2	4	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:179064256T>C	uc001gmd.2	+	6	1249	c.1097T>C	c.(1096-1098)ATA>ACA	p.I366T	TOR3A_uc010pnd.1_Missense_Mutation_p.I150T	NM_022371	NP_071766	Q9H497	TOR3A_HUMAN	torsin family 3, member A precursor	366					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			pancreas(1)	1						CTGGATGAAATAGCCCAGATG	0.507													27	311					0	0	0	0	C	179064256	C	C	179064256	3	2	40	1	0	0	0	0	1	0	0	0	16443	1406	49	5	1119	5	TOR3A	1	179064256	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	19888114	179064256	70186365	15	8514											
SOAT1	6646	broad.mit.edu	37	chr1	179310294	179310295	+	Frame_Shift_Ins	INS	-	T	T																															caacattgggccactggctaINStagcaagagttctcatccgc																										TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:179310294_179310295insT	uc001gml.2	+	7	692_693	c.629_630insT	c.(628-630)TATfs	p.Y210fs	SOAT1_uc010pni.1_Frame_Shift_Ins_p.Y145fs|SOAT1_uc001gmm.2_Frame_Shift_Ins_p.Y152fs|SOAT1_uc010pnj.1_5'UTR|SOAT1_uc010pnk.1_Frame_Shift_Ins_p.Y145fs	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	210					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	GCCACTGGCTATAGCAAGAGTT	0.431													---	---	---								T	179310295	T	T	179310294	7	5	40	1	0	1	1	0	0	0	0	0	14974	449	16	0	651	0	SOAT1	1	179310294	Frame_Shift_Ins	INS	-	TCGA-CN-4728-01A-01D-1434-08	246038	179310294	69940327	16	8515											
KIF14	9928	broad.mit.edu	37	chr1	200529861	200529861	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaattacctggacactggCagctttattgttaccgtttt	9	16	7	9	1	0	0	0	0	0	0	0	1	0	1	2	2	3	4	2	2	5	8			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:200529861C>A	uc010ppk.1	-	26	4658	c.4219G>T	c.(4219-4221)GCC>TCC	p.A1407S	KIF14_uc010ppj.1_Missense_Mutation_p.A916S	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1407	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TGGACACTGGCAGCTTTATTG	0.383													23	188					3.83957e-06	4.353e-06	1	0	A	200529861	A	A	200529861	3	1	40	1	0	0	0	0	1	0	0	0	8315	710	25	4	747	4	KIF14	1	200529861	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	21219567	200529861	48720760	17	8516											
CAMK1G	57172	broad.mit.edu	37	chr1	209786185	209786185	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtggcagctcccactgcCgggcagggcagactggagtc	7	5	15	14	1	0	1	0	0	0	1	2	2	1	2	3	4	2	4	3	4	0	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:209786185C>T	uc001hhd.2	+	12	1498	c.1396C>T	c.(1396-1398)CGG>TGG	p.R466W	CAMK1G_uc001hhe.2_Missense_Mutation_p.R466W	NM_020439	NP_065172	Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	466						Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		CTCCCACTGCCGGGCAGGGCA	0.502													8	121					0	0	0	0	T	209786185	T	T	209786185	3	4	40	1	0	0	0	0	1	0	0	0	2610	643	23	1	1438	1	CAMK1G	1	209786185	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	9256324	209786185	39464436	18	8517											
C1orf35	79169	broad.mit.edu	37	chr1	228288853	228288854	+	Frame_Shift_Ins	INS	-	T	T																															aggcctcagagcctctgtcaINStgccacctgcgagacgggct																										TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:228288853_228288854insT	uc001hrx.2	-	8	864_865	c.770_771insA	c.(769-771)CATfs	p.H257fs	C1orf35_uc009xew.2_RNA	NM_024319	NP_077295	Q9BU76	MMTA2_HUMAN	hypothetical protein LOC79169	257											0		Prostate(94;0.0488)				AGCCTCTGTCATGCCACCTGCG	0.634													---	---	---								T	228288854	T	T	228288853	7	5	40	1	0	1	1	0	0	0	0	0	2048	214	8	0	24	0	C1orf35	1	228288853	Frame_Shift_Ins	INS	-	TCGA-CN-4728-01A-01D-1434-08	18502668	228288853	20961768	19	8518											
AHCTF1	25909	broad.mit.edu	37	chr1	247059207	247059207	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtctgaattgctgctgacaaTatagcttctaactgttcttc	9	16	7	9	0	3	2	0	2	3	0	4	2	3	2	0	0	4	4	0	0	5	7			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:247059207T>C	uc001ibu.1	-	12	1651	c.1644A>G	c.(1642-1644)ATA>ATG	p.I548M	AHCTF1_uc001ibv.1_Missense_Mutation_p.I557M|AHCTF1_uc009xgs.1_Translation_Start_Site	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	548	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTGCTGACAATATAGCTTCTA	0.368													17	200					0	0	0	0	C	247059207	C	C	247059207	3	2	40	1	0	0	0	0	1	0	0	0	408	1396	49	5	5252	5	AHCTF1	1	247059207	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	18770354	247059207	2191414	20	8519											
OR2T33	391195	broad.mit.edu	37	chr1	248436962	248436962	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtacatgggcgtgtggagcCggtggtcccagtgaatcagg	8	8	17	8	2	1	1	1	1	0	0	2	2	2	2	2	5	2	1	2	5	2	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:248436962C>T	uc010pzi.1	-	1	155	c.155G>A	c.(154-156)CGG>CAG	p.R52Q		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CGTGTGGAGCCGGTGGTCCCA	0.527													33	200					0	0	0	0	T	248436962	T	T	248436962	3	4	40	1	0	0	0	0	1	0	0	0	11078	652	23	1	810	1	OR2T33	1	248436962	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	1377755	248436962	813659	21	8520											
OR2M7	391196	broad.mit.edu	37	chr1	248486986	248486986	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attaatgctctggtcacttcCttgttgcggaggctataaat	9	15	9	8	1	2	0	1	0	1	0	3	1	3	1	1	3	2	3	1	3	4	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr1:248486986C>A	uc010pzk.1	-	1	885	c.885G>T	c.(883-885)AAG>AAT	p.K295N		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGTCACTTCCTTGTTGCGGA	0.423													13	108					1.05317e-09	1.25225e-09	1	0	A	248486986	A	A	248486986	3	1	40	1	0	0	0	0	1	0	0	0	11068	680	24	4	56	4	OR2M7	1	248486986	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	50024	248486986	763635	22	8521											
ADCY3	109	broad.mit.edu	37	chr2	25062774	25062774	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccggcctccatcttgttggcTacagtgacatcagtcgacca	8	10	9	14	2	2	1	1	1	1	0	4	2	3	1	4	2	1	2	4	2	1	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:25062774T>A	uc002rfs.3	-	6	1522	c.1323A>T	c.(1321-1323)GTA>GTT	p.V441V	ADCY3_uc002rfr.3_Silent_p.V52V|ADCY3_uc010ykm.1_Silent_p.V441V	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	441	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					TCTTGTTGGCTACAGTGACAT	0.672													26	152					0	0	0	0	A	25062774	A	A	25062774	2	1	40	1	0	0	0	0	0	0	0	1	295	1509	53	5		5	ADCY3	2	25062774	Silent	SNP	T	TCGA-CN-4728-01A-01D-1434-08		25062774	218136599	23	8522											
EMILIN1	11117	broad.mit.edu	37	chr2	27306220	27306220	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccaagaggaactaggccGccttcgggatggtgtggagc	9	7	16	9	2	0	1	0	0	0	1	2	4	1	4	3	5	2	0	3	5	3	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:27306220G>A	uc002rii.3	+	4	2209	c.1781G>A	c.(1780-1782)CGC>CAC	p.R594H	EMILIN1_uc002rik.3_5'Flank	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	594	Potential.				cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAACTAGGCCGCCTTCGGGAT	0.697													19	97					0	0	0	0	A	27306220	A	A	27306220	3	1	40	1	0	0	0	0	1	0	0	0	5117	1087	38	1	1795	1	EMILIN1	2	27306220	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	2243446	27306220	215893153	24	8523											
CNGA3	1261	broad.mit.edu	37	chr2	99012566	99012566	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttggtcttgtacattctCatcatcatccactggaatgc	10	14	6	11	0	4	0	3	0	2	0	6	1	5	1	1	2	3	1	1	2	3	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:99012566C>T	uc002syt.2	+	8	1350	c.933C>T	c.(931-933)CTC>CTT	p.L311L	CNGA3_uc002syu.2_Silent_p.L293L|CNGA3_uc010fij.2_Silent_p.L315L	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	311	Helical; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						TGTACATTCTCATCATCATCC	0.458													17	175					0	0	0	0	T	99012566	T	T	99012566	2	4	40	1	0	0	0	0	0	0	0	1	3613	813	29	2		2	CNGA3	2	99012566	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	71706346	99012566	144186807	25	8524											
AFF3	3899	broad.mit.edu	37	chr2	100623856	100623856	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatctatcagttaaaaagtCtttcatttcatcataattgc	13	16	5	7	0	6	0	4	0	2	0	6	1	6	1	0	1	1	1	0	1	5	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:100623856C>G	uc002tag.2	-	5	477	c.241G>C	c.(241-243)GAC>CAC	p.D81H	AFF3_uc002taf.2_Missense_Mutation_p.D106H|AFF3_uc010fiq.1_Missense_Mutation_p.D81H|AFF3_uc010yvr.1_Missense_Mutation_p.D235H|AFF3_uc002tah.1_Missense_Mutation_p.D106H|AFF3_uc010fir.1_Missense_Mutation_p.D158H|AFF3_uc002tai.2_Missense_Mutation_p.D3H	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	81					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GTTAAAAAGTCTTTCATTTCA	0.418													32	161					0	0	0	0	G	100623856	G	G	100623856	3	3	40	1	0	0	0	0	1	0	0	0	358	913	32	2	3519	2	AFF3	2	100623856	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	1611290	100623856	142575517	26	8525											
SCN9A	6335	broad.mit.edu	37	chr2	167055509	167055509	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccgttttagtgtggttgtGatgggttcataggacacttt	6	18	12	5	1	1	1	1	1	0	0	2	2	2	2	1	3	0	3	1	3	2	7			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:167055509G>C	uc010fpl.2	-	27	5948	c.5607C>G	c.(5605-5607)ATC>ATG	p.I1869M	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1880						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GTGTGGTTGTGATGGGTTCAT	0.428													29	177					0	0	0	0	C	167055509	C	C	167055509	3	2	40	1	0	0	0	0	1	0	0	0	13990	1280	45	2	330	2	SCN9A	2	167055509	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	66431653	167055509	76143864	27	8526											
LRP2	4036	broad.mit.edu	37	chr2	170042510	170042510	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcgcagccactgattgaaggGtcatggcattcattaatgcc	10	11	10	10	1	2	2	2	2	0	0	3	2	2	2	2	2	2	2	2	2	2	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:170042510G>T	uc002ues.2	-	50	9561	c.9348C>A	c.(9346-9348)GAC>GAA	p.D3116E		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3116	EGF-like 11.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGATTGAAGGGTCATGGCATT	0.418													19	76					2.39187e-15	2.952e-15	1	0	T	170042510	T	T	170042510	3	4	40	1	0	0	0	0	1	0	0	0	9006	1252	44	4	4739	4	LRP2	2	170042510	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	2987001	170042510	73156863	28	8527											
FASTKD1	79675	broad.mit.edu	37	chr2	170403114	170403114	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtggtaaaacggcttcaaTtcgggatatccccacttcgt	9	12	9	11	3	1	0	1	0	0	0	4	1	2	1	2	3	1	2	2	3	4	5			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:170403114T>A	uc002uev.3	-	8	1703	c.1315A>T	c.(1315-1317)ATT>TTT	p.I439F	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.I425F	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	439					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						ACGGCTTCAATTCGGGATATC	0.408													13	105					0	0	0	0	A	170403114	A	A	170403114	3	1	40	1	0	0	0	0	1	0	0	0	5717	1493	52	5	1260	5	FASTKD1	2	170403114	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	360604	170403114	72796259	29	8528											
ANKAR	150709	broad.mit.edu	37	chr2	190608094	190608094	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgcaggaataaacctaatCagttcattcgtataaaaaat	19	11	5	6	1	2	0	2	0	0	0	3	1	2	1	1	1	2	3	1	1	9	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:190608094C>G	uc002uqw.1	+	20	3691	c.3691C>G	c.(3691-3693)CAG>GAG	p.Q1231E	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqx.1_RNA|ANKAR_uc002uqy.1_Intron	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1302						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TAAACCTAATCAGTTCATTCG	0.368													12	78					0	0	0	0	G	190608094	G	G	190608094	3	3	40	1	0	0	0	0	1	0	0	0	623	827	29	2	3982	2	ANKAR	2	190608094	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	20204980	190608094	52591279	30	8529											
PIKFYVE	200576	broad.mit.edu	37	chr2	209138378	209138378	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagccctcagctcccttcGaggacacagtctgttaggtc	8	9	9	15	1	2	0	1	0	1	0	5	2	3	1	3	2	2	2	3	2	1	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:209138378G>T	uc002vcz.2	+	3	401	c.243G>T	c.(241-243)TCG>TCT	p.S81S	PIKFYVE_uc010fun.1_5'UTR|PIKFYVE_uc002vcy.1_Silent_p.S81S|PIKFYVE_uc002vcv.2_Silent_p.S81S|PIKFYVE_uc002vcw.2_Silent_p.S81S|PIKFYVE_uc002vcx.2_Silent_p.S81S	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	81					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						AGCTCCCTTCGAGGACACAGT	0.493													10	122					0.000442599	0.000479483	1	0	T	209138378	T	T	209138378	2	4	40	1	0	0	0	0	0	0	0	1	11979	1045	37	3		3	PIKFYVE	2	209138378	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	18530284	209138378	34060995	31	8530											
VIL1	7429	broad.mit.edu	37	chr2	219314035	219314035	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgatggaagcaacaaaacctCaagaaagaaaaaggactatt	21	5	8	7	1	1	2	1	0	0	2	1	5	1	4	1	2	3	1	1	2	9	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:219314035C>G	uc002via.2	+	20	2525	c.2460C>G	c.(2458-2460)CTC>CTG	p.L820L	VIL1_uc010zke.1_Silent_p.L509L|VIL1_uc002vib.2_Silent_p.L820L	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	820	Headpiece.|HP.|LPA/PIP2-binding site 3.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AACAAAACCTCAAGAAAGAAA	0.448													34	245					0	0	0	0	G	219314035	G	G	219314035	2	3	40	1	0	0	0	0	0	0	0	1	17232	813	29	2		2	VIL1	2	219314035	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	10175657	219314035	23885338	32	8531											
WDFY1	57590	broad.mit.edu	37	chr2	224809872	224809872	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccgggccctacctgtcctCgctggccgtgatcacgccgt	3	8	12	18	5	1	1	1	1	0	0	3	1	2	1	6	2	1	1	6	2	1	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr2:224809872C>T	uc002vnq.2	-	1	181	c.130G>A	c.(130-132)GAG>AAG	p.E44K		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	44	WD 1.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		TACCTGTCCTCGCTGGCCGTG	0.751													5	26					0	0	0	0	T	224809872	T	T	224809872	3	4	40	1	0	0	0	0	1	0	0	0	17336	893	31	1	1150	1	WDFY1	2	224809872	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	5495837	224809872	18389501	33	8532											
GRIP2	80852	broad.mit.edu	37	chr3	14562009	14562009	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctggcgtcttgactatttCcaccatcaagggtcccgaag	8	10	9	14	2	2	1	1	1	1	0	4	2	4	1	4	2	0	0	4	2	3	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:14562009C>T	uc011avi.1	-	9	1039	c.1039G>A	c.(1039-1041)GAA>AAA	p.E347K	GRIP2_uc011avh.1_5'UTR	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	250	PDZ 3.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						TTGACTATTTCCACCATCAAG	0.552													4	38					0	0	0	0	T	14562009	T	T	14562009	3	4	40	1	0	0	0	0	1	0	0	0	6827	864	30	2	2453	2	GRIP2	3	14562009	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08		14562009	183460421	34	8533											
THRB	7068	broad.mit.edu	37	chr3	24174936	24174936	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggggcattgactattggtgcTtgtccaatgtcttctggcta	6	15	12	8	0	2	1	0	1	2	0	3	1	3	1	1	4	1	3	1	4	3	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:24174936T>G	uc003ccx.3	-	9	1105	c.756A>C	c.(754-756)CAA>CAC	p.Q252H	THRB_uc010hfe.2_Missense_Mutation_p.Q252H|THRB_uc003ccy.3_Missense_Mutation_p.Q252H|THRB_uc003ccz.3_Missense_Mutation_p.Q247H	NM_001128176	NP_001121648	P10828	THB_HUMAN	thyroid hormone receptor, beta	252	Ligand-binding.|Interaction with NR2F6.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			skin(2)|pancreas(1)	3					Levothyroxine(DB00451)|Liothyronine(DB00279)	CTATTGGTGCTTGTCCAATGT	0.393													5	82					0	0	0	0	G	24174936	G	G	24174936	3	3	40	1	0	0	0	0	1	0	0	0	15941	1606	56	5	641	5	THRB	3	24174936	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	9612927	24174936	173847494	35	8534											
C3orf23	285343	broad.mit.edu	37	chr3	44437946	44437946	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agccagctgcatagtttaagCcgcttagcacagcagaattt	12	10	9	10	1	0	1	0	0	0	1	0	1	0	1	2	0	6	6	2	0	4	5			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:44437946C>T	uc010him.2	+	7	995	c.750C>T	c.(748-750)AGC>AGT	p.S250S	C3orf23_uc003cnd.3_Silent_p.S250S|C3orf23_uc003cne.3_Silent_p.S106S	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	250						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		ATAGTTTAAGCCGCTTAGCAC	0.438													3	40					0	0	0	0	T	44437946	T	T	44437946	2	4	40	1	0	0	0	0	0	0	0	1	2226	738	26	4		4	C3orf23	3	44437946	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	20263010	44437946	153584484	36	8535											
ZNF660	285349	broad.mit.edu	37	chr3	44635868	44635868	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgggaaagcctttagtcaGagtgcaaacctcacagtaca	13	9	10	9	0	2	1	2	0	0	1	2	2	2	2	2	1	4	2	2	1	4	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:44635868G>A	uc003cnl.1	+	3	516	c.183G>A	c.(181-183)CAG>CAA	p.Q61Q		NM_173658	NP_775929	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	61	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		CCTTTAGTCAGAGTGCAAACC	0.438													6	63					0	0	0	0	A	44635868	A	A	44635868	2	1	40	1	0	0	0	0	0	0	0	1	18137	933	33	2		2	ZNF660	3	44635868	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	197922	44635868	153386562	37	8536											
NME6	10201	broad.mit.edu	37	chr3	48336722	48336722	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggatgtaggctcggattggCccgctgtgaacaaaacaagc	12	7	13	9	2	0	1	0	1	0	0	1	3	0	3	1	4	3	3	1	4	5	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:48336722C>T	uc003csp.3	-	5	288	c.237G>A	c.(235-237)GGG>GGA	p.G79G	NME6_uc003cso.2_Silent_p.G87G|NME6_uc011bbh.1_Missense_Mutation_p.G66D|NME6_uc010hju.2_5'UTR|NME6_uc011bbi.1_Intron	NM_005793	NP_005784	O75414	NDK6_HUMAN	nucleoside diphosphate kinase type 6	79					anti-apoptosis|apoptosis|CTP biosynthetic process|GTP biosynthetic process|negative regulation of cell growth|negative regulation of mitosis|UTP biosynthetic process	mitochondrion	ATP binding|metal ion binding|nucleoside diphosphate kinase activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		CTCGGATTGGCCCGCTGTGAA	0.552													3	37					0	0	0	0	T	48336722	T	T	48336722	2	4	40	1	0	0	0	0	0	0	0	1	10549	726	26	4		4	NME6	3	48336722	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	3700854	48336722	149685708	38	8537											
PBRM1	55193	broad.mit.edu	37	chr3	52643617	52643617	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catctccctccaggtctctgCgtgtttcaagcaggactttg	6	13	9	13	1	3	0	1	0	2	0	6	1	4	1	2	2	2	2	2	2	1	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:52643617C>T	uc003des.2	-	16	2291	c.2279G>A	c.(2278-2280)CGC>CAC	p.R760H	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.R760H|PBRM1_uc003der.2_Missense_Mutation_p.R728H|PBRM1_uc003det.2_Missense_Mutation_p.R775H|PBRM1_uc003deu.2_Missense_Mutation_p.R775H|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.R760H|PBRM1_uc010hmk.1_Missense_Mutation_p.R760H|PBRM1_uc003dey.2_Missense_Mutation_p.R760H|PBRM1_uc003dez.1_Missense_Mutation_p.R760H|PBRM1_uc003dfb.1_Missense_Mutation_p.R673H|PBRM1_uc003dfa.1_Missense_Mutation_p.R106H|PBRM1_uc003dfc.2_Missense_Mutation_p.R127H	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	760					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CAGGTCTCTGCGTGTTTCAAG	0.423			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								19	124					0	0	0	0	T	52643617	T	T	52643617	3	4	40	1	0	0	0	0	1	0	0	0	11545	768	27	1	2681	1	PBRM1	3	52643617	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	4306895	52643617	145378813	39	8538											
MYH15	22989	broad.mit.edu	37	chr3	108147437	108147437	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttctgcttgacctgctgtaGattttctacctggccctcga	5	16	8	12	1	2	2	0	1	2	1	3	3	2	2	3	1	3	3	3	1	2	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:108147437G>A	uc003dxa.1	-	28	3721	c.3664C>T	c.(3664-3666)CTA>TTA	p.L1222L		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1222	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						ACCTGCTGTAGATTTTCTACC	0.488													16	213					0	0	0	0	A	108147437	A	A	108147437	2	1	40	1	0	0	0	0	0	0	0	1	10087	933	33	2		2	MYH15	3	108147437	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	55503820	108147437	89874993	40	8539											
SLC9A10	285335	broad.mit.edu	37	chr3	111981806	111981806	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcagatccaaaataaagatCagagtaggcaagcagaaggg	18	5	12	6	0	2	4	2	0	0	4	3	4	3	4	1	2	1	3	1	2	7	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:111981806C>T	uc003dyu.2	-	10	1384	c.1162G>A	c.(1162-1164)GAT>AAT	p.D388N	SLC9A10_uc011bhu.1_Intron|SLC9A10_uc010hqc.2_Missense_Mutation_p.D340N	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	388					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						AAATAAAGATCAGAGTAGGCA	0.333													7	68					0	0	0	0	T	111981806	T	T	111981806	3	4	40	1	0	0	0	0	1	0	0	0	14774	826	29	2	2451	2	SLC9A10	3	111981806	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	3834369	111981806	86040624	41	8540											
RHO	6010	broad.mit.edu	37	chr3	129251462	129251462	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atcatcatggtcatcgctttCctgatctgctgggtgcccta	6	14	9	12	1	4	1	3	1	1	0	6	1	5	1	2	2	2	2	2	2	1	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:129251462C>G	uc003emt.2	+	4	878	c.783C>G	c.(781-783)TTC>TTG	p.F261L		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	261	Helical; Name=6; (Potential).				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	TCATCGCTTTCCTGATCTGCT	0.592													7	109					0	0	0	0	G	129251462	G	G	129251462	3	3	40	1	0	0	0	0	1	0	0	0	13395	854	30	2	797	2	RHO	3	129251462	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	17269656	129251462	68770968	42	8541											
IGSF10	285313	broad.mit.edu	37	chr3	151164902	151164903	+	Missense_Mutation	DNP	GT	TC	TC																															cactcacttctcttacagatGtctgatgactatttgtggta																										TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:151164902_151164903GT>TC	uc011bod.1	-	4	2866_2867	c.2866_2867AC>GA	c.(2866-2868)ACA>GAA	p.T956E		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	956					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTTACAGATGTCTGATGACTA	0.396													112	260					0	0	0	0	TC	151164903	TC	TC	151164902	3	4	40	1	0	0	0	0	1	0	0	0	7636	1377	48	4	5064	4	IGSF10	3	151164902	Missense_Mutation	DNP	GT	TCGA-CN-4728-01A-01D-1434-08	21913440	151164902	46857528	43	8542											
GOLIM4	27333	broad.mit.edu	37	chr3	167742808	167742808	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaattttcttctctcacttGctcggcttcttcaaattcat	8	18	3	12	1	6	0	3	0	3	0	8	0	6	0	0	1	1	2	0	1	2	7			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:167742808G>A	uc003ffe.2	-	13	2043	c.1699C>T	c.(1699-1701)CAA>TAA	p.Q567*	GOLIM4_uc011bpe.1_Nonsense_Mutation_p.Q568*|GOLIM4_uc011bpf.1_Nonsense_Mutation_p.Q540*|GOLIM4_uc011bpg.1_Nonsense_Mutation_p.Q539*	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	567	Glu-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						TCTCTCACTTGCTCGGCTTCT	0.373													29	269					0	0	0	0	A	167742808	A	A	167742808	4	1	40	1	0	0	0	0	0	1	0	0	6603	1328	46	4	407	4	GOLIM4	3	167742808	Nonsense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	16577906	167742808	30279622	44	8543											
PSMD2	5708	broad.mit.edu	37	chr3	184023708	184023708	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcctcttggactgggtctCaaccacctgggtgaggggat	6	11	13	11	0	2	1	1	1	2	0	4	3	3	3	3	5	1	0	3	5	1	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:184023708C>G	uc003fnn.1	+	13	1725	c.1692C>G	c.(1690-1692)CTC>CTG	p.L564L	PSMD2_uc011brj.1_Silent_p.L405L|PSMD2_uc011brk.1_Silent_p.L434L	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	564	PC 5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	GACTGGGTCTCAACCACCTGG	0.493											OREG0015947	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	132					0	0	0	0	G	184023708	G	G	184023708	2	3	40	1	0	0	0	0	0	0	0	1	12760	813	29	2		2	PSMD2	3	184023708	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	16280900	184023708	13998722	45	8544											
WDR53	348793	broad.mit.edu	37	chr3	196281368	196281368	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgcatcccacaacgtgatcTtcccatcattccctccagta	9	12	4	16	1	2	1	1	1	1	0	6	1	6	1	4	0	2	2	4	0	2	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr3:196281368T>C	uc003fwt.2	-	4	1262	c.791A>G	c.(790-792)AAG>AGG	p.K264R		NM_182627	NP_872433	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	264	WD 5.									breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CAACGTGATCTTCCCATCATT	0.468													19	220					0	0	0	0	C	196281368	C	C	196281368	3	2	40	1	0	0	0	0	1	0	0	0	17373	1609	56	5	289	5	WDR53	3	196281368	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	12257660	196281368	1741062	46	8545											
UGT2B10	7365	broad.mit.edu	37	chr4	69884067	69884067	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttcgcataagccatatgtCagcttttcccattgtctcag	8	15	7	11	1	2	0	2	0	1	0	5	0	3	0	2	0	2	3	2	0	2	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr4:69884067C>G	uc011cao.1	-	5	782	c.646G>C	c.(646-648)GAC>CAC	p.D216H	UGT2B10_uc011can.1_Missense_Mutation_p.D132H			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	253					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						AGCCATATGTCAGCTTTTCCC	0.363													33	256					0	0	0	0	G	69884067	G	G	69884067	3	3	40	1	0	0	0	0	1	0	0	0	17024	826	29	2	2460	2	UGT2B10	4	69884067	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08		69884067	121270209	47	8546											
CDS1	1040	broad.mit.edu	37	chr4	85538789	85538789	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtctatcattcttatgatCtaccatggtttagaacacta	12	15	6	8	0	4	2	1	1	3	1	4	3	4	2	1	1	2	1	1	1	6	7			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr4:85538789C>T	uc011ccv.1	+	4	913	c.415C>T	c.(415-417)CTA>TTA	p.L139L		NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	139					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		TTCTTATGATCTACCATGGTT	0.338													7	113					0	0	0	0	T	85538789	T	T	85538789	2	4	40	1	0	0	0	0	0	0	0	1	3192	912	32	2		2	CDS1	4	85538789	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	15654722	85538789	105615487	48	8547											
ADH5	128	broad.mit.edu	37	chr4	100003182	100003182	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacaattccagcaccttcaTgtcccaagatcactggaaaa	14	8	5	14	0	2	1	2	0	0	1	4	2	4	2	4	1	1	1	4	1	4	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr4:100003182T>C	uc003hui.2	-	3	280	c.200A>G	c.(199-201)CAT>CGT	p.H67R	ADH5_uc003huk.1_Missense_Mutation_p.H67R|ADH5_uc003huj.2_5'UTR	NM_000671	NP_000662	P11766	ADHX_HUMAN	class III alcohol dehydrogenase, chi subunit	67		Zinc 1; catalytic.			ethanol oxidation|response to redox state		alcohol dehydrogenase (NAD) activity|electron carrier activity|fatty acid binding|formaldehyde dehydrogenase activity|S-(hydroxymethyl)glutathione dehydrogenase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.5e-07)	NADH(DB00157)	AGCACCTTCATGTCCCAAGAT	0.453													15	74					0	0	0	0	C	100003182	C	C	100003182	3	2	40	1	0	0	0	0	1	0	0	0	311	1464	51	5	952	5	ADH5	4	100003182	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	14464393	100003182	91151094	49	8548											
TMEM184C	55751	broad.mit.edu	37	chr4	148539207	148539207	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttgcggttcccctatgcGtgtgggaattacagaaactg	8	12	13	8	2	0	1	0	0	0	1	1	2	1	2	2	3	4	2	2	3	4	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr4:148539207G>A	uc003ila.3	+	1	669	c.100G>A	c.(100-102)GTG>ATG	p.V34M		NM_018241	NP_060711	Q9NVA4	T184C_HUMAN	transmembrane protein 184C	34	Helical; (Potential).					integral to membrane					0						TCCCCTATGCGTGTGGGAATT	0.502											OREG0016353	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	278					0	0	0	0	A	148539207	A	A	148539207	3	1	40	1	0	0	0	0	1	0	0	0	16172	1145	40	1	102	1	TMEM184C	4	148539207	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	48536025	148539207	42615069	50	8549											
CLCN3	1182	broad.mit.edu	37	chr4	170628124	170628124	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtcatgaccagtaaatGggttggagatgcctttggca	10	11	13	7	0	1	2	1	1	0	1	1	3	1	2	2	3	2	4	2	3	2	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr4:170628124G>T	uc003isi.2	+	11	2365	c.1856G>T	c.(1855-1857)TGG>TTG	p.W619L	CLCN3_uc003ish.2_Missense_Mutation_p.W619L|CLCN3_uc011cjz.1_Missense_Mutation_p.W602L|CLCN3_uc011cka.1_Missense_Mutation_p.W592L|CLCN3_uc003isj.1_Missense_Mutation_p.W592L	NM_001829	NP_001820	P51790	CLCN3_HUMAN	chloride channel 3 isoform b	619	Helical; (By similarity).				endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(2)|ovary(1)	3		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		ACCAGTAAATGGGTTGGAGAT	0.438													6	130					1.12685e-05	1.27015e-05	1	0	T	170628124	T	T	170628124	3	4	40	1	0	0	0	0	1	0	0	0	3479	1357	47	4	1894	4	CLCN3	4	170628124	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	22088917	170628124	20526152	51	8550											
SPCS3	60559	broad.mit.edu	37	chr4	177249416	177249416	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctggaattctacctcttGtgacaggatcaggacacgta	11	11	10	9	1	3	1	1	1	2	0	3	4	3	4	1	3	2	2	1	3	3	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr4:177249416G>T	uc003iur.3	+	5	616	c.478G>T	c.(478-480)GTG>TTG	p.V160L		NM_021928	NP_068747	P61009	SPCS3_HUMAN	signal peptidase complex subunit 3	160	Lumenal (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			ovary(1)	1		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.43e-19)|Epithelial(43;1.84e-16)|OV - Ovarian serous cystadenocarcinoma(60;4.51e-09)|GBM - Glioblastoma multiforme(59;0.000142)|STAD - Stomach adenocarcinoma(60;0.00279)|LUSC - Lung squamous cell carcinoma(193;0.0319)		TCTACCTCTTGTGACAGGATC	0.348													13	90					1.5842e-08	1.86096e-08	1	0	T	177249416	T	T	177249416	3	4	40	1	0	0	0	0	1	0	0	0	15091	1377	48	4	496	4	SPCS3	4	177249416	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	6621292	177249416	13904860	52	8551											
HEATR7B2	133558	broad.mit.edu	37	chr5	41009477	41009477	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccactggaggctggcttttCagccagcgccttccacaatg	7	9	10	15	1	1	0	1	0	0	0	2	1	2	1	4	3	2	2	4	3	1	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr5:41009477C>T	uc003jmj.3	-	32	3815	c.3325G>A	c.(3325-3327)GAA>AAA	p.E1109K	HEATR7B2_uc003jmi.3_Missense_Mutation_p.E664K	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1109							binding			ovary(6)|central_nervous_system(2)	8						GCTGGCTTTTCAGCCAGCGCC	0.498													11	114					0	0	0	0	T	41009477	T	T	41009477	3	4	40	1	0	0	0	0	1	0	0	0	7074	835	29	2	1476	2	HEATR7B2	5	41009477	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08		41009477	139905783	53	8552											
HTR1A	3350	broad.mit.edu	37	chr5	63257049	63257049	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcatgggcgggatagagatGaggaagccaataagccaagt	15	5	15	6	1	0	2	0	1	0	1	0	5	0	4	2	3	3	1	2	3	5	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr5:63257049G>A	uc011cqt.1	-	1	498	c.498C>T	c.(496-498)CTC>CTT	p.L166L		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	166	Helical; Name=4; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GGATAGAGATGAGGAAGCCAA	0.607													8	99					0	0	0	0	A	63257049	A	A	63257049	2	1	40	1	0	0	0	0	0	0	0	1	7475	1277	45	2		2	HTR1A	5	63257049	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	22247572	63257049	117658211	54	8553											
EBF1	1879	broad.mit.edu	37	chr5	158223429	158223429	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccctatgatgatcacagtcGcacctcccgtcgtccatcct	7	10	6	18	3	1	2	1	2	0	0	6	2	4	2	6	0	0	1	6	0	1	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr5:158223429G>A	uc010jip.2	-	9	1135	c.833C>T	c.(832-834)GCG>GTG	p.A278V	EBF1_uc011ddw.1_Missense_Mutation_p.A146V|EBF1_uc011ddx.1_Missense_Mutation_p.A279V|EBF1_uc003lxl.3_Missense_Mutation_p.A247V	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	278	IPT/TIG.				multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GATCACAGTCGCACCTCCCGT	0.463			T	HMGA2	lipoma								8	89					0	0	0	0	A	158223429	A	A	158223429	3	1	40	1	0	0	0	0	1	0	0	0	4902	1087	38	1	974	1	EBF1	5	158223429	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	94966380	158223429	22691831	55	8554											
FLT4	2324	broad.mit.edu	37	chr5	180048861	180048861	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accggctggccctctagtagCtcctcggatggcttggattc	5	11	12	13	2	1	0	0	0	1	0	4	2	2	2	3	5	1	4	3	5	2	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr5:180048861C>A	uc003mma.3	-	13	1780	c.1701G>T	c.(1699-1701)GAG>GAT	p.E567D	FLT4_uc003mlz.3_Missense_Mutation_p.E567D|FLT4_uc003mmb.1_Missense_Mutation_p.E100D|FLT4_uc011dgy.1_Missense_Mutation_p.E567D	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	567	Ig-like C2-type 6.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CCTCTAGTAGCTCCTCGGATG	0.622									Congenital_Hereditary_Lymphedema				11	97					0.00010058	0.000112075	1	0	A	180048861	A	A	180048861	3	1	40	1	0	0	0	0	1	0	0	0	5976	796	28	4	2470	4	FLT4	5	180048861	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	21825432	180048861	866399	56	8555											
DST	667	broad.mit.edu	37	chr6	56504792	56504792	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctctatgaacatttttatGattttctaaatggctttcaa	12	18	5	6	0	3	2	1	2	2	0	3	2	3	2	0	1	2	2	0	1	6	8			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr6:56504792G>T	uc003pdf.2	-	18	2483	c.2455C>A	c.(2455-2457)CAT>AAT	p.H819N	DST_uc003pcz.3_Missense_Mutation_p.H641N|DST_uc011dxj.1_Missense_Mutation_p.H670N|DST_uc011dxk.1_Missense_Mutation_p.H681N|DST_uc011dxl.1_Missense_Mutation_p.H670N|DST_uc003pcy.3_Missense_Mutation_p.H315N|DST_uc003pdb.2_Missense_Mutation_p.H315N|DST_uc003pdc.3_Missense_Mutation_p.H315N|DST_uc003pdd.3_Missense_Mutation_p.H315N|DST_uc003pde.2_Missense_Mutation_p.H757N	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	641					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACATTTTTATGATTTTCTAAA	0.308													7	116					0.000157383	0.000173388	1	0	T	56504792	T	T	56504792	3	4	40	1	0	0	0	0	1	0	0	0	4805	1290	45	2	19532	2	DST	6	56504792	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08		56504792	114610275	57	8556			1	9		4	3	427	N	G	2.536849e-06
DST	667	broad.mit.edu	37	chr6	56505116	56505116	+	Nonsense_Mutation	SNP	G	C	C																															tgaaatttggaactaatcctGatgggaaaccaggtgtataa																										TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr6:56505116G>C	uc003pdf.2	-	17	2244	c.2216C>G	c.(2215-2217)TCA>TGA	p.S739*	DST_uc003pcz.3_Nonsense_Mutation_p.S561*|DST_uc011dxj.1_Nonsense_Mutation_p.S590*|DST_uc011dxk.1_Nonsense_Mutation_p.S601*|DST_uc011dxl.1_Nonsense_Mutation_p.S590*|DST_uc003pcy.3_Nonsense_Mutation_p.S235*|DST_uc003pdb.2_Nonsense_Mutation_p.S235*|DST_uc003pdc.3_Nonsense_Mutation_p.S235*|DST_uc003pdd.3_Nonsense_Mutation_p.S235*|DST_uc003pde.2_Nonsense_Mutation_p.S677*	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	561					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AACTAATCCTGATGGGAAACC	0.453													9	140					0	0	0	0	C	56505116	C	C	56505116	4	2	40	1	0	0	0	0	0	1	0	0	4805	1294	45	2	19775	2	DST	6	56505116	Nonsense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	324	56505116	114609951	58	8557	18	2	1	9		4	3	427	N	G	2.536849e-06
DST	667	broad.mit.edu	37	chr6	56505121	56505121	+	Missense_Mutation	SNP	G	T	T																															tttggaactaatcctgatggGaaaccaggtgtataagctgg																										TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr6:56505121G>T	uc003pdf.2	-	17	2239	c.2211C>A	c.(2209-2211)TTC>TTA	p.F737L	DST_uc003pcz.3_Missense_Mutation_p.F559L|DST_uc011dxj.1_Missense_Mutation_p.F588L|DST_uc011dxk.1_Missense_Mutation_p.F599L|DST_uc011dxl.1_Missense_Mutation_p.F588L|DST_uc003pcy.3_Missense_Mutation_p.F233L|DST_uc003pdb.2_Missense_Mutation_p.F233L|DST_uc003pdc.3_Missense_Mutation_p.F233L|DST_uc003pdd.3_Missense_Mutation_p.F233L|DST_uc003pde.2_Missense_Mutation_p.F675L	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	559					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATCCTGATGGGAAACCAGGTG	0.443													11	141					2.61681e-11	3.14987e-11	1	0	T	56505121	T	T	56505121	3	4	40	1	0	0	0	0	1	0	0	0	4805	1165	41	2	19780	2	DST	6	56505121	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	5	56505121	114609946	59	8558	18	2	1	9		4	3	427	N	G	2.536849e-06
DST	667	broad.mit.edu	37	chr6	56505218	56505218	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagaagaggttagggaaggtGttaaactctgggtcagccct	11	10	14	6	0	2	2	1	0	1	2	2	3	2	3	1	4	2	2	1	4	6	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr6:56505218G>A	uc003pdf.2	-	17	2142	c.2114C>T	c.(2113-2115)ACA>ATA	p.T705I	DST_uc003pcz.3_Missense_Mutation_p.T527I|DST_uc011dxj.1_Missense_Mutation_p.T556I|DST_uc011dxk.1_Missense_Mutation_p.T567I|DST_uc011dxl.1_Missense_Mutation_p.T556I|DST_uc003pcy.3_Missense_Mutation_p.T201I|DST_uc003pdb.2_Missense_Mutation_p.T201I|DST_uc003pdc.3_Missense_Mutation_p.T201I|DST_uc003pdd.3_Missense_Mutation_p.T201I|DST_uc003pde.2_Missense_Mutation_p.T643I	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	527					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TAGGGAAGGTGTTAAACTCTG	0.478													14	169					0	0	0	0	A	56505218	A	A	56505218	3	1	40	1	0	0	0	0	1	0	0	0	4805	1377	48	4	19877	4	DST	6	56505218	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	97	56505218	114609849	60	8559			1	9		4	3	427	N	G	2.536849e-06
RSPH4A	345895	broad.mit.edu	37	chr6	116949382	116949382	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtcctctaggattttatcaGtttggtgaagaggaaggaga	12	12	13	4	0	2	3	1	1	1	2	3	6	3	5	1	4	0	1	1	4	4	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr6:116949382G>C	uc003pxe.2	+	3	1657	c.1512G>C	c.(1510-1512)CAG>CAC	p.Q504H	RSPH4A_uc010kee.2_Missense_Mutation_p.Q504H	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	504					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						GATTTTATCAGTTTGGTGAAG	0.453									Kartagener_syndrome				12	136					0	0	0	0	C	116949382	C	C	116949382	3	2	40	1	0	0	0	0	1	0	0	0	13771	1020	36	4	1522	4	RSPH4A	6	116949382	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	60444164	116949382	54165685	61	8560											
SASH1	23328	broad.mit.edu	37	chr6	148865488	148865488	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacgagtttgaaggaacacAccatcccctgggcaccaaag	14	5	9	13	1	0	1	0	1	0	0	1	3	1	2	4	2	1	2	4	2	3	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr6:148865488A>G	uc003qme.1	+	18	3357	c.2882A>G	c.(2881-2883)CAC>CGC	p.H961R	SASH1_uc011eeb.1_Missense_Mutation_p.H722R|SASH1_uc003qmf.1_Missense_Mutation_p.H371R	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	961							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GAAGGAACACACCATCCCCTG	0.522													8	133					0	0	0	0	G	148865488	G	G	148865488	3	3	40	1	0	0	0	0	1	0	0	0	13913	159	6	5	2952	5	SASH1	6	148865488	Missense_Mutation	SNP	A	TCGA-CN-4728-01A-01D-1434-08	31916106	148865488	22249579	62	8561											
SYNE1	23345	broad.mit.edu	37	chr6	152469388	152469388	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcgagcgagagggagagAttggaggaaggctgtggaga	12	5	21	3	2	0	4	0	1	0	3	0	11	0	7	0	5	2	1	0	5	1	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr6:152469388A>G	uc010kiw.2	-	137	25370	c.24768T>C	c.(24766-24768)AAT>AAC	p.N8256N	SYNE1_uc010kiv.2_Silent_p.N2780N|SYNE1_uc003qos.3_Silent_p.N2780N|SYNE1_uc003qot.3_Silent_p.N8185N|SYNE1_uc003qou.3_Silent_p.N8256N|SYNE1_uc003qop.3_Silent_p.N418N|SYNE1_uc011eez.1_Silent_p.N458N|SYNE1_uc003qoq.3_Silent_p.N458N|SYNE1_uc003qor.3_Silent_p.N1156N	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8256	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGAGGGAGAGATTGGAGGAAG	0.632										HNSCC(10;0.0054)			6	85					0	0	0	0	G	152469388	G	G	152469388	2	3	40	1	0	0	0	0	0	0	0	1	15511	330	12	5		5	SYNE1	6	152469388	Silent	SNP	A	TCGA-CN-4728-01A-01D-1434-08	3603900	152469388	18645679	63	8562											
C6orf118	168090	broad.mit.edu	37	chr6	165715310	165715310	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctcctgcgccatccaggaggGccccgtccaggagggcctcc	5	5	13	18	2	0	0	0	0	0	0	4	2	4	2	8	4	1	0	8	4	0	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr6:165715310G>A	uc003qum.3	-	2	537	c.501C>T	c.(499-501)GGC>GGT	p.G167G	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	167											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		ATCCAGGAGGGCCCCGTCCAG	0.627													8	156					0	0	0	0	A	165715310	A	A	165715310	2	1	40	1	0	0	0	0	0	0	0	1	2333	1190	42	4		4	C6orf118	6	165715310	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	13245922	165715310	5399757	64	8563											
DAGLB	221955	broad.mit.edu	37	chr7	6449640	6449640	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtgtgaccacttggcgctaTagtgagcagcagagcagcag	10	7	14	10	2	0	3	0	2	0	1	0	3	0	3	1	1	4	5	1	1	2	3	rs138947170		TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr7:6449640T>C	uc003sqa.2	-	15	2017	c.1847A>G	c.(1846-1848)TAT>TGT	p.Y616C	DAGLB_uc003spy.2_Missense_Mutation_p.Y162C|DAGLB_uc003spz.2_Missense_Mutation_p.Y313C|DAGLB_uc011jwt.1_Missense_Mutation_p.Y430C|DAGLB_uc011jwu.1_Missense_Mutation_p.Y487C|DAGLB_uc003sqb.2_Missense_Mutation_p.Y335C|DAGLB_uc003sqc.2_Missense_Mutation_p.Y335C|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Missense_Mutation_p.Y575C	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	616	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		CTTGGCGCTATAGTGAGCAGC	0.597													7	100					0	0	0	0	C	6449640	C	C	6449640	3	2	40	1	0	0	0	0	1	0	0	0	4244	1406	49	5	175	5	DAGLB	7	6449640	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08		6449640	152689023	65	8564											
BMPER	168667	broad.mit.edu	37	chr7	34097738	34097738	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaaggcaggacggagtgtcGcaataagcagtgcattccca	13	6	13	9	2	0	0	0	0	0	0	2	3	1	2	1	3	2	4	1	3	3	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr7:34097738G>A	uc011kap.1	+	10	1109	c.995G>A	c.(994-996)CGC>CAC	p.R332H		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	332	VWFC 5.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						ACGGAGTGTCGCAATAAGCAG	0.493													8	86					0	0	0	0	A	34097738	A	A	34097738	3	1	40	1	0	0	0	0	1	0	0	0	1471	1087	38	1	1033	1	BMPER	7	34097738	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	27648098	34097738	125040925	66	8565											
ZNF117	51351	broad.mit.edu	37	chr7	64453119	64453119	+	5'Flank	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccccttcctttgacccgaCatgaatttcaaaccaggtcc	10	11	5	15	1	1	2	1	2	0	0	4	3	4	2	6	1	1	0	6	1	2	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr7:64453119C>A	uc003ttr.2	-						ZNF117_uc011kdr.1_Missense_Mutation_p.V93F	NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				tttgacccgacatgaatttca	0													6	60					8.12818e-05	9.10917e-05	1	0	A	64453119	A	A	64453119	1	1	40	0	1	0	0	0	0	0	0	0	17784	478	17	4		4	ZNF117	7	64453119	5'Flank	SNP	C	TCGA-CN-4728-01A-01D-1434-08	30355381	64453119	94685544	67	8566											
KIAA1549	57670	broad.mit.edu	37	chr7	138602370	138602370	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcaaacaatgtaaatgtctCaaccaagggagaaaaagact	19	7	8	7	0	2	2	2	0	1	2	3	3	2	2	1	1	2	1	1	1	8	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr7:138602370C>T	uc011kql.1	-	2	2051	c.2002G>A	c.(2002-2004)GAG>AAG	p.E668K	KIAA1549_uc003vuk.3_Missense_Mutation_p.E618K|KIAA1549_uc011kqj.1_Missense_Mutation_p.E668K	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	668	Ser-rich.					integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GTAAATGTCTCAACCAAGGGA	0.502			O	BRAF	pilocytic astrocytoma								3	24					0	0	0	0	T	138602370	T	T	138602370	3	4	40	1	0	0	0	0	1	0	0	0	8283	835	29	2	3926	2	KIAA1549	7	138602370	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	74149251	138602370	20536293	68	8567											
DNAJB6	10049	broad.mit.edu	37	chr7	157160131	157160131	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtaacccagatgatgtcttCagggaattttttggtggaag	10	13	12	6	1	2	2	1	1	1	1	2	4	2	4	1	3	1	1	1	3	3	5			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr7:157160131C>T	uc003wnk.2	+	5	454	c.300C>T	c.(298-300)TTC>TTT	p.F100F	DNAJB6_uc003wnj.2_Silent_p.F100F|DNAJB6_uc003wnl.2_Silent_p.F87F|DNAJB6_uc011kvy.1_Silent_p.F51F|DNAJB6_uc011kvz.1_Silent_p.F100F|DNAJB6_uc010lqt.2_Silent_p.F100F	NM_058246	NP_490647	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	100	Gly/Phe-rich.|Interaction with HSP70.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding			ovary(2)	2	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		ATGATGTCTTCAGGGAATTTT	0.408													18	242					0	0	0	0	T	157160131	T	T	157160131	2	4	40	1	0	0	0	0	0	0	0	1	4646	825	29	2		2	DNAJB6	7	157160131	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	18557761	157160131	1978532	69	8568											
CYP7A1	1581	broad.mit.edu	37	chr8	59409510	59409510	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgtaagatctctgccaaaGatagttaaatacccagcttc	13	12	6	10	0	1	2	0	0	1	2	3	2	1	2	2	0	3	3	2	0	6	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr8:59409510G>A	uc003xtm.3	-	3	624	c.561C>T	c.(559-561)ATC>ATT	p.I187I		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	187					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				CTCTGCCAAAGATAGTTAAAT	0.453									Neonatal_Giant_Cell_Hepatitis				28	218					0	0	0	0	A	59409510	A	A	59409510	2	1	40	1	0	0	0	0	0	0	0	1	4213	932	33	2		2	CYP7A1	8	59409510	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08		59409510	86954512	70	8569											
PREX2	80243	broad.mit.edu	37	chr8	69021852	69021852	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagatgtgtgtttgtcaaaTagatgagtaagtgttttgta	11	16	13	1	0	1	3	1	1	0	2	1	4	1	3	0	1	0	4	0	1	4	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr8:69021852T>G	uc003xxv.1	+	25	3167	c.3140T>G	c.(3139-3141)ATA>AGA	p.I1047R	PREX2_uc011lez.1_Missense_Mutation_p.I982R	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1047					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GTTTGTCAAATAGATGAGTAA	0.348													34	99					0	0	0	0	G	69021852	G	G	69021852	3	3	40	1	0	0	0	0	1	0	0	0	12539	1406	49	5	3467	5	PREX2	8	69021852	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	9612342	69021852	77342170	71	8570											
FER1L6	654463	broad.mit.edu	37	chr8	125076788	125076788	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aacacacacctgtagcccagGagccaccaaaagatggaaaa	18	3	8	12	0	0	1	0	0	0	1	0	3	0	3	4	2	3	1	4	2	6	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr8:125076788G>T	uc003yqw.2	+	26	3735	c.3529G>T	c.(3529-3531)GAG>TAG	p.E1177*	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1177	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TGTAGCCCAGGAGCCACCAAA	0.527													7	120					0.000274275	0.000298791	1	0	T	125076788	T	T	125076788	4	4	40	1	0	0	0	0	0	1	0	0	5847	1175	41	2	3627	2	FER1L6	8	125076788	Nonsense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	56054936	125076788	21287234	72	8571											
RNF139	11236	broad.mit.edu	37	chr8	125498931	125498931	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgggctaagaccagaagaGagacttattcgcttaagtag	14	9	12	6	1	0	4	0	0	0	4	1	5	0	4	1	1	0	3	1	1	5	5			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr8:125498931G>A	uc003yrc.2	+	2	1384	c.1041G>A	c.(1039-1041)GAG>GAA	p.E347E		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	347					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GACCAGAAGAGAGACTTATTC	0.413									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				50	350					0	0	0	0	A	125498931	A	A	125498931	2	1	40	1	0	0	0	0	0	0	0	1	13507	933	33	2		2	RNF139	8	125498931	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	422143	125498931	20865091	73	8572											
ADCY8	114	broad.mit.edu	37	chr8	131880122	131880122	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagcaaactttgtattgccGtgataaatagaagaacgata	17	10	9	5	2	0	3	0	1	0	2	0	5	0	3	1	0	4	2	1	0	9	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr8:131880122G>A	uc003ytd.3	-	9	2436	c.2180C>T	c.(2179-2181)ACG>ATG	p.T727M	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	727	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TTGTATTGCCGTGATAAATAG	0.353										HNSCC(32;0.087)			18	113					0	0	0	0	A	131880122	A	A	131880122	3	1	40	1	0	0	0	0	1	0	0	0	300	1145	40	1	1615	1	ADCY8	8	131880122	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	6381191	131880122	14483900	74	8573											
OC90	729330	broad.mit.edu	37	chr8	133062085	133062085	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccacgtgacatggctgtaatGtatcacagatgataacgtct	12	11	9	9	2	2	3	1	2	1	1	2	3	2	3	1	1	1	3	1	1	3	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr8:133062085G>C	uc003ytg.2	-	1	32	c.32C>G	c.(31-33)ACA>AGA	p.T11R	OC90_uc011lix.1_Intron	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	Error:Variant_position_missing_in_Q02509_after_alignment					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TGGCTGTAATGTATCACAGAT	0.408													8	162					0	0	0	0	C	133062085	C	C	133062085	3	2	40	1	0	0	0	0	1	0	0	0	10868	1392	48	4		4	OC90	8	133062085	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	1181963	133062085	13301937	75	8574											
FAM135B	51059	broad.mit.edu	37	chr8	139380208	139380208	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctaccgaaaactcaaccgTtccttgtatttcagacatga	12	12	5	12	2	3	2	2	1	1	1	4	3	4	2	3	0	3	2	3	0	5	5			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr8:139380208T>G	uc003yuy.2	-	2	190	c.19A>C	c.(19-21)ACG>CCG	p.T7P	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	7										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AACTCAACCGTTCCTTGTATT	0.323										HNSCC(54;0.14)			18	201					0	0	0	0	G	139380208	G	G	139380208	3	3	40	1	0	0	0	0	1	0	0	0	5477	1725	60	5	4277	5	FAM135B	8	139380208	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	6318123	139380208	6983814	76	8575											
ZCCHC6	79670	broad.mit.edu	37	chr9	88940312	88940312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agataccaattctttgacacGaatacttatcactaaatcag	16	12	4	9	1	3	2	2	1	1	1	3	3	3	2	1	0	2	0	1	0	7	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr9:88940312G>A	uc004aoq.2	-	12	1941	c.1726C>T	c.(1726-1728)CGT>TGT	p.R576C	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.R453C|ZCCHC6_uc004aou.2_Missense_Mutation_p.R576C	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	576	PAP-associated 1.				RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TCTTTGACACGAATACTTATC	0.423													4	137					0	0	0	0	A	88940312	A	A	88940312	3	1	40	1	0	0	0	0	1	0	0	0	17659	1058	37	1	2825	1	ZCCHC6	9	88940312	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08		88940312	52273119	77	8576											
C9orf47	286223	broad.mit.edu	37	chr9	91605992	91605992	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaaccctcgctgtcagggCgacaggcgcccgcccaagcc	9	3	11	18	4	1	0	1	0	0	0	2	1	1	0	4	2	2	1	4	2	2	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr9:91605992C>G	uc004aqd.2	+	1	215	c.82C>G	c.(82-84)CGA>GGA	p.R28G	S1PR3_uc004aqe.2_5'Flank|C9orf47_uc004aqc.1_Missense_Mutation_p.R28G	NM_001001938	NP_001001938	Q6ZRZ4	CI047_HUMAN	hypothetical protein LOC286223 isoform 1	28						extracellular region					0						GCTGTCAGGGCGACAGGCGCC	0.567													7	50					0	0	0	0	G	91605992	G	G	91605992	3	3	40	1	0	0	0	0	1	0	0	0	2497	760	27	3	84	3	C9orf47	9	91605992	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	2665680	91605992	49607439	78	8577											
PTCH1	5727	broad.mit.edu	37	chr9	98209663	98209663	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cttgccgtccgggaggcaggGaccctgagtccaggtggggc	5	6	18	12	2	0	1	0	1	0	0	2	3	2	3	4	6	1	1	4	6	0	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr9:98209663G>A	uc004avk.3	-	23	4063	c.3875C>T	c.(3874-3876)TCC>TTC	p.S1292F	PTCH1_uc010mrn.2_Missense_Mutation_p.S84F|PTCH1_uc010mro.2_Missense_Mutation_p.S1141F|PTCH1_uc010mrp.2_Missense_Mutation_p.S1141F|PTCH1_uc010mrq.2_Missense_Mutation_p.S1141F|PTCH1_uc004avl.3_Missense_Mutation_p.S1141F|PTCH1_uc010mrr.2_Missense_Mutation_p.S1226F|PTCH1_uc004avm.3_Missense_Mutation_p.S1291F	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1292	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.S1292F(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GGGAGGCAGGGACCCTGAGTC	0.652									Basal_Cell_Nevus_syndrome				15	184					0	0	0	0	A	98209663	A	A	98209663	3	1	40	1	0	0	0	0	1	0	0	0	12792	1174	41	2	472	2	PTCH1	9	98209663	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	6603671	98209663	43003768	79	8578											
CAMSAP1	157922	broad.mit.edu	37	chr9	138714638	138714638	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgctgggcctcctagacacGatgctcctcggtctcccttc	4	11	9	17	3	1	1	0	0	1	1	7	2	3	1	4	2	1	2	4	2	1	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr9:138714638G>A	uc004cgr.3	-	11	1869	c.1869C>T	c.(1867-1869)ATC>ATT	p.I623I	CAMSAP1_uc004cgq.3_Silent_p.I513I|CAMSAP1_uc010nbg.2_Silent_p.I345I	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	623						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		TCCTAGACACGATGCTCCTCG	0.547													11	138					0	0	0	0	A	138714638	A	A	138714638	2	1	40	1	0	0	0	0	0	0	0	1	2623	1048	37	1		1	CAMSAP1	9	138714638	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	40504975	138714638	2498793	80	8579											
COL13A1	1305	broad.mit.edu	37	chr10	71707080	71707080	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggtttacatggaccaccCggggacaagggaaaccgggt	11	5	15	10	2	0	0	0	0	0	0	0	3	0	3	3	6	2	1	3	6	3	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr10:71707080C>T	uc001jpr.1	+	36	2543	c.2007C>T	c.(2005-2007)CCC>CCT	p.P669P	COL13A1_uc001jqj.1_Silent_p.P642P|COL13A1_uc001jps.1_Silent_p.P640P|COL13A1_uc001jpt.1_Silent_p.P628P|COL13A1_uc001jpu.1_Silent_p.P638P|COL13A1_uc001jpv.1_Silent_p.P643P|COL13A1_uc001jpx.1_Silent_p.P620P|COL13A1_uc001jpw.1_Silent_p.P616P|COL13A1_uc001jpy.1_Silent_p.P607P|COL13A1_uc001jpz.1_Silent_p.P612P|COL13A1_uc001jqa.1_Silent_p.P609P|COL13A1_uc001jqc.1_Silent_p.P654P|COL13A1_uc001jqb.1_Silent_p.P591P|COL13A1_uc001jql.2_Silent_p.P669P|COL13A1_uc001jqd.1_Silent_p.P657P|COL13A1_uc001jqe.1_Silent_p.P652P|COL13A1_uc001jqf.1_Silent_p.P650P|COL13A1_uc001jqg.1_Silent_p.P647P|COL13A1_uc001jqh.1_Silent_p.P657P|COL13A1_uc001jqi.1_Silent_p.P655P|COL13A1_uc010qjf.1_Silent_p.P444P	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	669	Extracellular (Potential).|Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	ATGGACCACCCGGGGACAAGG	0.517													4	80					0	0	0	0	T	71707080	T	T	71707080	2	4	40	1	0	0	0	0	0	0	0	1	3685	639	23	1		1	COL13A1	10	71707080	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08		71707080	63827667	81	8580											
KIF20B	9585	broad.mit.edu	37	chr10	91476203	91476203	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttttttaaagatctacaatgGattcaagtatctgattccaa	14	16	5	6	0	3	2	1	1	2	1	4	3	4	3	1	1	1	1	1	1	7	7			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr10:91476203G>C	uc001kgs.1	+	9	1023	c.951G>C	c.(949-951)TGG>TGC	p.W317C	KIF20B_uc001kgr.1_Missense_Mutation_p.W317C	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	317	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						ATCTACAATGGATTCAAGTAT	0.303													5	46					0	0	0	0	C	91476203	C	C	91476203	3	2	40	1	0	0	0	0	1	0	0	0	8326	1183	41	2	981	2	KIF20B	10	91476203	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	19769123	91476203	44058544	82	8581											
CYP26C1	340665	broad.mit.edu	37	chr10	94824176	94824176	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagctgcatcggcacctggaGggggccatttctgagaagct	8	8	14	11	1	1	1	0	1	1	1	2	3	1	2	2	4	3	4	2	4	1	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr10:94824176G>A	uc010qns.1	+	4	744	c.744G>A	c.(742-744)GAG>GAA	p.E248E	CYP26C1_uc009xud.2_Intron	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	248					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)				GGCACCTGGAGGGGGCCATTT	0.612													3	66					0	0	0	0	A	94824176	A	A	94824176	2	1	40	1	0	0	0	0	0	0	0	1	4174	991	35	4		4	CYP26C1	10	94824176	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	3347973	94824176	40710571	83	8582											
PDZD7	79955	broad.mit.edu	37	chr10	102781636	102781636	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgtcgtcaaacctgacaccGttggctgccaggacctggtc	8	9	11	13	2	1	1	1	1	0	0	3	2	1	2	4	3	2	2	4	3	1	1	rs148746572		TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr10:102781636G>A	uc001kso.1	-	6	1001	c.786C>T	c.(784-786)AAC>AAT	p.N262N	PDZD7_uc001ksn.2_Silent_p.N262N	NM_024895	NP_079171	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	262	PDZ 2.					cilium|nucleus	protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		ACCTGACACCGTTGGCTGCCA	0.622													24	160					0	0	0	0	A	102781636	A	A	102781636	2	1	40	1	0	0	0	0	0	0	0	1	11758	1136	40	1		1	PDZD7	10	102781636	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	7957460	102781636	32753111	84	8583											
HTRA1	5654	broad.mit.edu	37	chr10	124266371	124266371	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggctccgcaactcagacatGgactacatccagaccgacgc	11	5	10	15	3	1	2	1	0	0	2	3	4	3	3	3	2	2	2	3	2	2	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr10:124266371G>A	uc001lgj.2	+	4	1070	c.942G>A	c.(940-942)ATG>ATA	p.M314I		NM_002775	NP_002766	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1 precursor	314	Serine protease.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				ACTCAGACATGGACTACATCC	0.602													15	78					0	0	0	0	A	124266371	A	A	124266371	3	1	40	1	0	0	0	0	1	0	0	0	7492	1348	47	4	956	4	HTRA1	10	124266371	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	21484735	124266371	11268376	85	8584											
OR5P2	120065	broad.mit.edu	37	chr11	7817810	7817810	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccttgtggtgcccctcaGtggagcgcatcttcaggatg	6	10	14	11	1	3	0	2	0	1	0	3	2	3	2	3	4	2	1	3	4	0	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:7817810G>T	uc001mfp.1	-	1	680	c.680C>A	c.(679-681)ACT>AAT	p.T227N		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTGCCCCTCAGTGGAGCGCAT	0.483													7	122					0.00198382	0.00213726	1	0	T	7817810	T	T	7817810	3	4	40	1	0	0	0	0	1	0	0	0	11232	1029	36	4	292	4	OR5P2	11	7817810	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08		7817810	127188706	86	8585											
SPON1	10418	broad.mit.edu	37	chr11	14282159	14282159	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccatgcttgctgtccccAtggtccgagtggagtgactg	6	11	12	12	1	0	1	0	1	0	0	3	3	3	2	4	2	2	2	4	2	0	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:14282159A>T	uc001mle.2	+	15	2395	c.1857A>T	c.(1855-1857)CCA>CCT	p.P619P		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	619	TSP type-1 4.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		TGCTGTCCCCATGGTCCGAGT	0.547													10	85					0	0	0	0	T	14282159	T	T	14282159	2	4	40	1	0	0	0	0	0	0	0	1	15148	204	8	5		5	SPON1	11	14282159	Silent	SNP	A	TCGA-CN-4728-01A-01D-1434-08	6464349	14282159	120724357	87	8586											
TTC17	55761	broad.mit.edu	37	chr11	43413095	43413096	+	Frame_Shift_Ins	INS	-	A	A																															actaaaattctagaacttccINSatatagtatacatgcttttc																								rs138517922	by1000genomes	TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:43413095_43413096insA	uc001mxi.2	+	4	514_515	c.500_501insA	c.(499-501)CCAfs	p.P167fs	TTC17_uc001mxh.2_Frame_Shift_Ins_p.P167fs|TTC17_uc010rfj.1_Frame_Shift_Ins_p.P110fs	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	167							binding			ovary(5)	5						CTAGAACTTCCATATAGTATAC	0.356													---	---	---								A	43413096	A	A	43413095	7	5	40	1	0	1	1	0	0	0	0	0	16752	594	21	0	514	0	TTC17	11	43413095	Frame_Shift_Ins	INS	-	TCGA-CN-4728-01A-01D-1434-08	29130936	43413095	91593421	88	8587											
CELF1	10658	broad.mit.edu	37	chr11	47508744	47508744	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatgttgtgaagagcattCtgagcttctaatgcagcttt	9	16	9	7	0	3	3	1	2	2	1	3	3	3	3	0	0	4	5	0	0	2	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:47508744C>G	uc001nfl.2	-	2	238	c.228G>C	c.(226-228)CAG>CAC	p.Q76H	CELF1_uc001nfm.2_Missense_Mutation_p.Q76H|CELF1_uc001nfn.2_Missense_Mutation_p.Q76H|CELF1_uc001nfo.1_Missense_Mutation_p.Q103H|CELF1_uc010rhm.1_Missense_Mutation_p.Q76H|CELF1_uc001nfp.2_Missense_Mutation_p.Q103H|CELF1_uc001nfq.1_Missense_Mutation_p.Q76H|CELF1_uc001nfr.1_Missense_Mutation_p.Q76H	NM_001025596	NP_001020767	Q92879	CELF1_HUMAN	CUG triplet repeat, RNA-binding protein 1	76	RRM 1.				embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|ovary(1)	3						GAAGAGCATTCTGAGCTTCTA	0.373													4	187					0	0	0	0	G	47508744	G	G	47508744	3	3	40	1	0	0	0	0	1	0	0	0	3230	912	32	2	1279	2	CELF1	11	47508744	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	4095649	47508744	87497772	89	8588											
OR5R1	219479	broad.mit.edu	37	chr11	56185534	56185534	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtggctgaggaaatagtacaTaggtgtgtggagtcgagtat	11	11	16	3	1	0	1	0	1	0	0	1	4	0	3	0	4	1	3	0	4	5	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:56185534T>A	uc010rji.1	-	1	175	c.175A>T	c.(175-177)ATG>TTG	p.M59L		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AAATAGTACATAGGTGTGTGG	0.438													10	73					0	0	0	0	A	56185534	A	A	56185534	3	1	40	1	0	0	0	0	1	0	0	0	11234	1406	49	5	801	5	OR5R1	11	56185534	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	8676790	56185534	78820982	90	8589											
SSRP1	6749	broad.mit.edu	37	chr11	57094220	57094220	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctcttgttctctcccgaaGagctctcatcactagacaca	9	12	6	14	1	4	2	2	0	3	2	7	3	5	2	1	0	2	3	1	0	2	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:57094220G>A	uc001njt.2	-	16	2282	c.2015C>T	c.(2014-2016)TCT>TTT	p.S672F	TNKS1BP1_uc001njs.2_5'Flank|TNKS1BP1_uc009ymd.1_5'Flank	NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	672	Ser-rich.				DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						CTCTCCCGAAGAGCTCTCATC	0.552													6	146					0	0	0	0	A	57094220	A	A	57094220	3	1	40	1	0	0	0	0	1	0	0	0	15260	942	33	2	122	2	SSRP1	11	57094220	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	908686	57094220	77912296	91	8590											
CTNND1	1500	broad.mit.edu	37	chr11	57569359	57569359	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gacagccagagctgccagagGtgatcgccatgcttggattc	9	8	13	11	1	0	3	0	1	0	2	2	5	0	4	3	2	4	2	3	2	0	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:57569359G>T	uc001nmc.3	+	7	1682	c.1111G>T	c.(1111-1113)GTG>TTG	p.V371L	CTNND1_uc001nlh.1_Missense_Mutation_p.V371L|CTNND1_uc001nlu.3_Missense_Mutation_p.V270L|CTNND1_uc001nlt.3_Missense_Mutation_p.V270L|CTNND1_uc001nls.3_Missense_Mutation_p.V270L|CTNND1_uc001nlw.3_Missense_Mutation_p.V270L|CTNND1_uc001nmf.3_Missense_Mutation_p.V371L|CTNND1_uc001nmd.3_Missense_Mutation_p.V317L|CTNND1_uc001nlk.3_Missense_Mutation_p.V317L|CTNND1_uc001nme.3_Missense_Mutation_p.V371L|CTNND1_uc001nll.3_Missense_Mutation_p.V317L|CTNND1_uc001nmg.3_Missense_Mutation_p.V317L|CTNND1_uc001nlj.3_Missense_Mutation_p.V317L|CTNND1_uc001nlr.3_Missense_Mutation_p.V317L|CTNND1_uc001nlp.3_Missense_Mutation_p.V317L|CTNND1_uc001nlx.3_Missense_Mutation_p.V48L|CTNND1_uc001nlz.3_Missense_Mutation_p.V48L|CTNND1_uc009ymn.2_Missense_Mutation_p.V48L|CTNND1_uc001nlm.3_Missense_Mutation_p.V371L|CTNND1_uc001nly.3_Missense_Mutation_p.V48L|CTNND1_uc001nmb.3_Missense_Mutation_p.V48L|CTNND1_uc001nma.3_Missense_Mutation_p.V48L|CTNND1_uc001nmi.3_Missense_Mutation_p.V270L|CTNND1_uc001nmh.3_Missense_Mutation_p.V371L|CTNND1_uc001nlq.3_Missense_Mutation_p.V270L|CTNND1_uc001nln.3_Missense_Mutation_p.V371L|CTNND1_uc001nli.3_Missense_Mutation_p.V371L|CTNND1_uc001nlo.3_Missense_Mutation_p.V270L|CTNND1_uc001nlv.3_Missense_Mutation_p.V270L	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	371	ARM 1.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				GCTGCCAGAGGTGATCGCCAT	0.537													6	104					0.000157383	0.000173388	1	0	T	57569359	T	T	57569359	3	4	40	1	0	0	0	0	1	0	0	0	4036	1261	44	4	1129	4	CTNND1	11	57569359	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	475139	57569359	77437157	92	8591											
INTS5	80789	broad.mit.edu	37	chr11	62416747	62416747	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggtctgtagagggggtctGagaagagcttccaccactac	9	8	15	9	0	2	3	0	1	2	3	3	4	3	3	2	4	2	2	2	4	3	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:62416747G>C	uc001nud.2	-	2	858	c.805C>G	c.(805-807)CAG>GAG	p.Q269E	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	269					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						GAGGGGGTCTGAGAAGAGCTT	0.577													4	70					0	0	0	0	C	62416747	C	C	62416747	3	2	40	1	0	0	0	0	1	0	0	0	7820	1299	45	2	2258	2	INTS5	11	62416747	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	4847388	62416747	72589769	93	8592											
CCND1	595	broad.mit.edu	37	chr11	69457891	69457891	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctggagcccgtgaaaaagagCcgcctgcagctgctgggggc	8	5	16	12	2	0	2	0	1	0	1	0	3	0	3	3	3	5	3	3	3	2	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:69457891C>T	uc001opa.2	+	2	500	c.291C>T	c.(289-291)AGC>AGT	p.S97S		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	97	Cyclin N-terminal.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	TGAAAAAGAGCCGCCTGCAGC	0.602			T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			4	101					0	0	0	0	T	69457891	T	T	69457891	2	4	40	1	0	0	0	0	0	0	0	1	2931	738	26	4		4	CCND1	11	69457891	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	7041144	69457891	65548625	94	8593											
ORAOV1	220064	broad.mit.edu	37	chr11	69482751	69482751	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaatttctggatcattccaAtcaatgattctaagaccttc	12	14	6	9	0	4	2	2	1	2	1	6	4	5	4	2	2	0	0	2	2	4	5			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:69482751A>G	uc001opc.2	-	4	415	c.257T>C	c.(256-258)ATT>ACT	p.I86T	ORAOV1_uc010rqi.1_Missense_Mutation_p.I86T|ORAOV1_uc009ysm.2_RNA|ORAOV1_uc001opd.2_Missense_Mutation_p.I27T	NM_153451	NP_703152	Q8WV07	ORAV1_HUMAN	oral cancer overexpressed 1	86											0	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;5.64e-57)|all cancers(3;5.98e-51)|BRCA - Breast invasive adenocarcinoma(2;5.49e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			GATCATTCCAATCAATGATTC	0.403													9	699					0	0	0	0	G	69482751	G	G	69482751	3	3	40	1	0	0	0	0	1	0	0	0	11314	101	4	5	164	5	ORAOV1	11	69482751	Missense_Mutation	SNP	A	TCGA-CN-4728-01A-01D-1434-08	24860	69482751	65523765	95	8594											
TAGLN	6876	broad.mit.edu	37	chr11	117075006	117075006	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgtcattggccttcagatGggcagcaacagaggggcctc	9	8	13	11	0	2	2	2	0	0	2	3	2	2	2	2	4	2	2	2	4	1	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:117075006G>A	uc001pqm.2	+	5	658	c.537G>A	c.(535-537)ATG>ATA	p.M179I	uc001pqk.1_5'Flank|TAGLN_uc001pql.1_Intron|TAGLN_uc001pqn.2_Missense_Mutation_p.M179I|TAGLN_uc001pqo.2_Missense_Mutation_p.M179I|TAGLN_uc001pqp.2_Missense_Mutation_p.M179I|uc001pqq.1_5'Flank	NM_003186	NP_003177	Q01995	TAGL_HUMAN	transgelin	179	Calponin-like.			M -> V (in Ref. 2; AAA58375).	muscle organ development	cytoplasm	actin binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|Epithelial(105;5.49e-05)|all cancers(92;0.000435)		GCCTTCAGATGGGCAGCAACA	0.587													3	99					0	0	0	0	A	117075006	A	A	117075006	3	1	40	1	0	0	0	0	1	0	0	0	15604	1348	47	4	551	4	TAGLN	11	117075006	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	47592255	117075006	17931510	96	8595											
HYOU1	10525	broad.mit.edu	37	chr11	118921809	118921809	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agccttgatgcccttggactCgtagtcaggatacttcttga	8	13	10	10	1	2	2	1	2	1	0	3	4	2	4	2	2	3	1	2	2	2	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr11:118921809C>T	uc001puu.2	-	14	1796	c.1603G>A	c.(1603-1605)GAG>AAG	p.E535K	HYOU1_uc001put.2_Missense_Mutation_p.E500K|HYOU1_uc010ryu.1_Missense_Mutation_p.E555K|HYOU1_uc010ryv.1_Missense_Mutation_p.E424K|HYOU1_uc001pux.3_Missense_Mutation_p.E535K|HYOU1_uc010ryw.1_RNA|HYOU1_uc001puw.1_Missense_Mutation_p.E535K	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	535						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		CCCTTGGACTCGTAGTCAGGA	0.527													6	81					0	0	0	0	T	118921809	T	T	118921809	3	4	40	1	0	0	0	0	1	0	0	0	7509	893	31	1	1448	1	HYOU1	11	118921809	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	1846803	118921809	16084707	97	8596											
CD163	9332	broad.mit.edu	37	chr12	7637727	7637727	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggtctcctccgaggggctgGccagtctcttctcccatgga	5	10	12	14	1	3	0	0	0	3	0	7	2	4	1	4	5	0	1	4	5	0	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr12:7637727G>C	uc001qsz.3	-	11	2872	c.2744C>G	c.(2743-2745)GCC>GGC	p.A915G	CD163_uc001qta.3_Missense_Mutation_p.A915G|CD163_uc009zfw.2_Missense_Mutation_p.A948G	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	915	SRCR 8.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CGAGGGGCTGGCCAGTCTCTT	0.517													18	214					0	0	0	0	C	7637727	C	C	7637727	3	2	40	1	0	0	0	0	1	0	0	0	2982	1203	42	4	750	4	CD163	12	7637727	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08		7637727	126214168	98	8597											
EPS8	2059	broad.mit.edu	37	chr12	15776179	15776179	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcatccttattgagagaGaaaagttgtgcaccatttaa	14	13	8	6	0	1	2	1	1	0	2	2	4	2	2	2	0	1	3	2	0	4	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr12:15776179G>T	uc009zif.2	-	20	2362	c.2268C>A	c.(2266-2268)TTC>TTA	p.F756L	EPS8_uc001rdb.2_Missense_Mutation_p.F756L|EPS8_uc009zig.2_Missense_Mutation_p.F496L|EPS8_uc010shv.1_Missense_Mutation_p.F496L	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	756					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		TATTGAGAGAGAAAAGTTGTG	0.378													19	120					1.67942e-08	1.96099e-08	1	0	T	15776179	T	T	15776179	3	4	40	1	0	0	0	0	1	0	0	0	5218	933	33	2	208	2	EPS8	12	15776179	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	8138452	15776179	118075716	99	8598											
OR6C70	390327	broad.mit.edu	37	chr12	55863666	55863666	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaggaaatggtcttttccCtggtaacaatggtgattagg	11	13	11	6	0	1	1	0	1	1	0	2	2	2	2	1	5	2	1	1	5	5	5			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr12:55863666C>T	uc010spn.1	-	1	257	c.257G>A	c.(256-258)AGG>AAG	p.R86K		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGTCTTTTCCCTGGTAACAAT	0.378													18	131					0	0	0	0	T	55863666	T	T	55863666	3	4	40	1	0	0	0	0	1	0	0	0	11251	681	24	4	683	4	OR6C70	12	55863666	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	40087487	55863666	77988229	100	8599											
DNAJC14	85406	broad.mit.edu	37	chr12	56221277	56221277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaactattcttaccagcCgctgccatggcctgctatct	8	12	7	14	1	2	1	0	1	2	0	2	1	2	1	4	1	5	2	4	1	4	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr12:56221277C>T	uc001shx.1	-	2	1370	c.1166G>A	c.(1165-1167)CGG>CAG	p.R389Q	DNAJC14_uc001shu.1_Missense_Mutation_p.R389Q|DNAJC14_uc009zob.1_Missense_Mutation_p.R389Q|DNAJC14_uc001shy.1_Missense_Mutation_p.R389Q	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	389					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						TCTTACCAGCCGCTGCCATGG	0.547													7	157					0	0	0	0	T	56221277	T	T	56221277	3	4	40	1	0	0	0	0	1	0	0	0	4655	652	23	1	966	1	DNAJC14	12	56221277	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	357611	56221277	77630618	101	8600											
TIMELESS	8914	broad.mit.edu	37	chr12	56814387	56814387	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggccgaacccctagcttgCgcaacagctgctgaaactgt	9	7	12	13	2	0	1	0	1	0	0	0	2	0	1	3	2	7	4	3	2	4	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr12:56814387C>T	uc001slf.2	-	26	3362	c.3194G>A	c.(3193-3195)CGC>CAC	p.R1065H		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	1065					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CCCTAGCTTGCGCAACAGCTG	0.428													11	148					0	0	0	0	T	56814387	T	T	56814387	3	4	40	1	0	0	0	0	1	0	0	0	15970	768	27	1	448	1	TIMELESS	12	56814387	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	593110	56814387	77037508	102	8601			2	10		3	3	802	C		8.966924e-06
TIMELESS	8914	broad.mit.edu	37	chr12	56814831	56814831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttctgagcccccttcttCttcctcttcgctgtcttcct	1	18	5	17	1	5	1	0	1	5	0	8	1	7	1	4	0	2	2	4	0	0	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr12:56814831C>T	uc001slf.2	-	24	3124	c.2956G>A	c.(2956-2958)GAA>AAA	p.E986K		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	986					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CCCCCTTCTTCTTCCTCTTCG	0.478													13	236					0	0	0	0	T	56814831	T	T	56814831	3	4	40	1	0	0	0	0	1	0	0	0	15970	922	32	2	694	2	TIMELESS	12	56814831	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	444	56814831	77037064	103	8602			2	10		3	3	802	C		8.966924e-06
TIMELESS	8914	broad.mit.edu	37	chr12	56815188	56815188	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgtacagctcccgccgctCagccaccagccccagagcca	8	5	8	20	2	1	1	1	0	0	1	2	1	2	1	7	0	5	3	7	0	1	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr12:56815188C>A	uc001slf.2	-	23	2983	c.2815G>T	c.(2815-2817)GAG>TAG	p.E939*		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	939					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						TCCCGCCGCTCAGCCACCAGC	0.512													11	205					4.3838e-07	5.02848e-07	1	0	A	56815188	A	A	56815188	4	1	40	1	0	0	0	0	0	1	0	0	15970	835	29	2	839	2	TIMELESS	12	56815188	Nonsense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	357	56815188	77036707	104	8603			2	10		3	3	802	C		8.966924e-06
PIP4K2C	79837	broad.mit.edu	37	chr12	57992919	57992919	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taccgagtcagtgtggacaaCgaagacagctacatgcttgt	12	9	11	9	2	1	1	1	0	0	1	1	4	1	2	1	1	5	2	1	1	4	3	rs147041101		TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr12:57992919C>T	uc001sou.2	+	5	716	c.585C>T	c.(583-585)AAC>AAT	p.N195N	PIP4K2C_uc001sot.2_Silent_p.N195N|PIP4K2C_uc010srs.1_Silent_p.N177N|PIP4K2C_uc010srt.1_Silent_p.N147N	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	195	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					GTGTGGACAACGAAGACAGCT	0.512													14	138					0	0	0	0	T	57992919	T	T	57992919	2	4	40	1	0	0	0	0	0	0	0	1	11993	535	19	1		1	PIP4K2C	12	57992919	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	1177731	57992919	75858976	105	8604											
TMTC2	160335	broad.mit.edu	37	chr12	83251023	83251023	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctcttcacaagcttctcCaagatcctccttggtgatgg	7	13	9	12	0	3	2	1	1	2	1	7	2	5	2	3	3	1	1	3	3	2	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr12:83251023C>A	uc001szt.2	+	2	750	c.318C>A	c.(316-318)TCC>TCA	p.S106S	TMTC2_uc001szr.1_Silent_p.S106S|TMTC2_uc001szs.1_Silent_p.S106S|TMTC2_uc010suk.1_Intron	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	106						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CAAGCTTCTCCAAGATCCTCC	0.522													16	141					2.62699e-14	3.20164e-14	1	0	A	83251023	A	A	83251023	2	1	40	1	0	0	0	0	0	0	0	1	16327	581	21	4		4	TMTC2	12	83251023	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	25258104	83251023	50600872	106	8605											
GCN1L1	10985	broad.mit.edu	37	chr12	120597955	120597955	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggccactcacctcctgcagCcgcctccggacctgcgcctc	4	7	9	21	3	1	0	1	0	0	0	4	1	3	1	8	2	3	1	8	2	0	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr12:120597955C>T	uc001txo.2	-	23	2554	c.2541G>A	c.(2539-2541)CGG>CGA	p.R847R		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	847					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCTCCTGCAGCCGCCTCCGGA	0.612													4	86					0	0	0	0	T	120597955	T	T	120597955	2	4	40	1	0	0	0	0	0	0	0	1	6334	726	26	4		4	GCN1L1	12	120597955	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	37346932	120597955	13253940	107	8606											
SETDB2	83852	broad.mit.edu	37	chr13	50054403	50054403	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaaggaatgccaaaacttcCcccttgtcaagtgacaaaat	15	8	7	11	0	1	1	1	1	0	0	2	2	2	2	3	1	2	1	3	1	7	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr13:50054403C>T	uc001vcz.2	+	8	1860	c.954C>T	c.(952-954)TCC>TCT	p.S318S	SETDB2_uc010adg.2_Silent_p.S294S|SETDB2_uc001vcy.3_Silent_p.S306S|SETDB2_uc010adh.2_Silent_p.S306S|SETDB2_uc001vda.2_Silent_p.S306S	NM_031915	NP_114121	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2 isoform a	318	Pre-SET.				cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		CCAAAACTTCCCCCTTGTCAA	0.408													23	270					0	0	0	0	T	50054403	T	T	50054403	2	4	40	1	0	0	0	0	0	0	0	1	14204	610	22	4		4	SETDB2	13	50054403	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08		50054403	65115475	108	8607											
SOX21	11166	broad.mit.edu	37	chr13	95364121	95364135	+	In_Frame_Del	DEL	GGCCTCGTCGATGAA	-	-																															tgcatggcgcgtagacgcttGgcctcgtcgatgaacggccg																										TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr13:95364121_95364135delGGCCTCGTCGATGAA	uc001vma.2	-	1	255_269	c.169_183delTTCATCGACGAGGCC	c.(169-183)TTCATCGACGAGGCCdel	p.FIDEA57del	uc001vmb.1_5'Flank	NM_007084	NP_009015	Q9Y651	SOX21_HUMAN	SRY-box 21	57_61	HMG box.				regulation of transcription from RNA polymerase II promoter|stem cell differentiation	nucleus	DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity				0	all_neural(89;0.0646)|Medulloblastoma(90;0.163)					GTAGACGCTTGGCCTCGTCGATGAACGGCCGCTTC	0.614													---	---	---								-	95364135	-	-	95364121	7	5	40	1	0	1	0	1	0	0	0	0	15014	1335	47	0	651	0	SOX21	13	95364121	In_Frame_Del	DEL	GGCCTCGTCGATGAA	TCGA-CN-4728-01A-01D-1434-08	45309718	95364121	19805757	109	8608											
ATP4B	496	broad.mit.edu	37	chr13	114307336	114307336	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaaactctcctggaagaagTactgctcggaggtgcagttg	10	9	14	8	1	1	1	0	0	1	1	3	4	1	4	1	4	4	4	1	4	4	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr13:114307336T>C	uc001vtz.2	-	4	449	c.407A>G	c.(406-408)TAC>TGC	p.Y136C	ATP4B_uc010agy.1_Missense_Mutation_p.Y136C	NM_000705	NP_000696	P51164	ATP4B_HUMAN	hydrogen/potassium-exchanging ATPase 4B	136	Extracellular (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	hydrogen:potassium-exchanging ATPase activity|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.171)		Rabeprazole(DB01129)	CTGGAAGAAGTACTGCTCGGA	0.617													5	96					0	0	0	0	C	114307336	C	C	114307336	3	2	40	1	0	0	0	0	1	0	0	0	1148	1638	57	5	484	5	ATP4B	13	114307336	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	18943215	114307336	862542	110	8609											
TOX4	9878	broad.mit.edu	37	chr14	21963465	21963466	+	Frame_Shift_Ins	INS	-	A	A																															caccccagcctcgatgtgtgINSaggtctggttgtgagaaccc																										TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr14:21963465_21963466insA	uc001waz.2	+	8	1822_1823	c.1719_1720insA	c.(1717-1722)GTGAGGfs	p.V573fs	TOX4_uc001way.2_Frame_Shift_Ins_p.V443fs|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Frame_Shift_Ins_p.V550fs|TOX4_uc010tlv.1_Frame_Shift_Ins_p.V443fs	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	573_574						chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		CTCGATGTGTGAGGTCTGGTTG	0.505													---	---	---								A	21963466	A	A	21963465	7	5	40	1	0	1	1	0	0	0	0	0	16447	1277	45	0	1749	0	TOX4	14	21963465	Frame_Shift_Ins	INS	-	TCGA-CN-4728-01A-01D-1434-08		21963465	85386075	111	8610											
C14orf118	55668	broad.mit.edu	37	chr14	76644359	76644359	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aagcgttggcttctgattttCctcacatttctgcttgtgca	6	17	8	10	1	3	1	1	1	2	0	4	1	4	1	1	1	3	4	1	1	1	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr14:76644359C>G	uc001xsh.2	+	7	1167	c.1081C>G	c.(1081-1083)CCT>GCT	p.P361A	C14orf118_uc001xsi.2_Intron|C14orf118_uc001xsl.2_Intron	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	361										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		TTCTGATTTTCCTCACATTTC	0.338													3	125					0	0	0	0	G	76644359	G	G	76644359	3	3	40	1	0	0	0	0	1	0	0	0	1747	855	30	2	1147	2	C14orf118	14	76644359	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	54680894	76644359	30705181	112	8611											
ANGEL1	23357	broad.mit.edu	37	chr14	77269772	77269772	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctactggtcgctgacaagcGatgctgcagaagcggaaacg	11	6	13	11	4	0	2	0	1	0	1	1	4	0	3	1	2	6	3	1	2	4	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr14:77269772G>A	uc001xsv.2	-	7	1673	c.1560C>T	c.(1558-1560)ATC>ATT	p.I520I	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	520										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		GCTGACAAGCGATGCTGCAGA	0.473													5	91					0	0	0	0	A	77269772	A	A	77269772	2	1	40	1	0	0	0	0	0	0	0	1	608	1048	37	1		1	ANGEL1	14	77269772	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	625413	77269772	30079768	113	8612											
TMEM63C	57156	broad.mit.edu	37	chr14	77685844	77685844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttcctggcctgtagctcGtccttgtggtttactccttc	2	18	8	13	1	0	0	0	0	0	0	5	0	3	0	4	2	2	3	4	2	2	7			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr14:77685844G>A	uc001xtf.2	+	4	366	c.154G>A	c.(154-156)GTC>ATC	p.V52I	TMEM63C_uc010asq.1_Missense_Mutation_p.V52I	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	52	Helical; (Potential).					integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		CCTGTAGCTCGTCCTTGTGGT	0.592													17	155					0	0	0	0	A	77685844	A	A	77685844	3	1	40	1	0	0	0	0	1	0	0	0	16258	1145	40	1	160	1	TMEM63C	14	77685844	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	416072	77685844	29663696	114	8613											
AVEN	57099	broad.mit.edu	37	chr15	34163164	34163164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttcggcagcaacgttgagtCggaggcagagaggcagctct	9	7	16	9	3	1	2	0	1	1	1	3	4	1	3	0	4	3	7	0	4	1	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr15:34163164C>T	uc001zhj.2	-	4	640	c.584G>A	c.(583-585)CGA>CAA	p.R195Q		NM_020371	NP_065104	Q9NQS1	AVEN_HUMAN	cell death regulator aven	195					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			kidney(1)	1		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		AACGTTGAGTCGGAGGCAGAG	0.438													5	46					0	0	0	0	T	34163164	T	T	34163164	3	4	40	1	0	0	0	0	1	0	0	0	1228	884	31	1	516	1	AVEN	15	34163164	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08		34163164	68368228	115	8614											
HERC1	8925	broad.mit.edu	37	chr15	64067311	64067311	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccaactttgtcttagaagcGcaaataataaacttagacca	16	11	5	9	1	1	2	0	0	1	2	2	2	2	2	2	0	3	1	2	0	8	5			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr15:64067311G>A	uc002amp.2	-	2	660	c.512C>T	c.(511-513)GCG>GTG	p.A171V	HERC1_uc010uil.1_Missense_Mutation_p.A171V|HERC1_uc010bgt.1_Missense_Mutation_p.A171V|HERC1_uc002amq.1_Missense_Mutation_p.A171V	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	171					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TCTTAGAAGCGCAAATAATAA	0.448													5	387					0	0	0	0	A	64067311	A	A	64067311	3	1	40	1	0	0	0	0	1	0	0	0	7096	1087	38	1	14381	1	HERC1	15	64067311	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	29904147	64067311	38464081	116	8615											
ISLR2	57611	broad.mit.edu	37	chr15	74427051	74427051	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacccgcgtgcttcgtacctCgagtccgagaaaagctaccc	9	7	10	15	5	0	1	0	0	0	1	3	4	1	1	4	0	4	3	4	0	4	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr15:74427051C>T	uc002axd.2	+	4	2725	c.1956C>T	c.(1954-1956)CTC>CTT	p.L652L	ISLR2_uc002axe.2_Silent_p.L652L|ISLR2_uc010bjg.2_Silent_p.L652L|ISLR2_uc010bjf.2_Silent_p.L652L	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	652	Cytoplasmic (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						CTTCGTACCTCGAGTCCGAGA	0.677											OREG0023277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	101					0	0	0	0	T	74427051	T	T	74427051	2	4	40	1	0	0	0	0	0	0	0	1	7898	871	31	1		1	ISLR2	15	74427051	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	10359740	74427051	28104341	117	8616											
PTPN9	5780	broad.mit.edu	37	chr15	75815511	75815511	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagagcctgaagtaccacatGttggactgacttgtggggat	10	10	13	8	0	0	3	0	2	0	1	0	5	0	5	2	3	2	2	2	3	2	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr15:75815511G>C	uc002bal.2	-	4	881	c.373C>G	c.(373-375)CAT>GAT	p.H125D		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	125	CRAL-TRIO.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						AGTACCACATGTTGGACTGAC	0.428													5	62					0	0	0	0	C	75815511	C	C	75815511	3	2	40	1	0	0	0	0	1	0	0	0	12859	1377	48	4	1448	4	PTPN9	15	75815511	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	1388460	75815511	26715881	118	8617											
AKAP13	11214	broad.mit.edu	37	chr15	86122930	86122930	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgctgccagttccctggAtggtaacaaacctgctgagt	8	10	10	13	0	0	1	0	1	0	0	1	2	1	2	4	2	5	4	4	2	2	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr15:86122930A>T	uc002blv.1	+	7	1801	c.1631A>T	c.(1630-1632)GAT>GTT	p.D544V	AKAP13_uc002blt.1_Missense_Mutation_p.D544V|AKAP13_uc002blu.1_Missense_Mutation_p.D544V	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	544					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						AGTTCCCTGGATGGTAACAAA	0.468													15	126					0	0	0	0	T	86122930	T	T	86122930	3	4	40	1	0	0	0	0	1	0	0	0	449	333	12	5	1653	5	AKAP13	15	86122930	Missense_Mutation	SNP	A	TCGA-CN-4728-01A-01D-1434-08	10307419	86122930	16408462	119	8618											
FANCI	55215	broad.mit.edu	37	chr15	89836226	89836226	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attggcataaaaaataatatCtgtgcttttcttgtgatggg	12	16	9	4	0	2	1	0	1	2	0	2	1	2	1	0	2	1	2	0	2	5	7			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr15:89836226C>G	uc010bnp.1	+	22	2313	c.2223C>G	c.(2221-2223)ATC>ATG	p.I741M	FANCI_uc002bnm.1_Missense_Mutation_p.I741M|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.I562M|FANCI_uc002bnq.1_Missense_Mutation_p.I154M	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	741					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					AAAATAATATCTGTGCTTTTC	0.313								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				15	139					0	0	0	0	G	89836226	G	G	89836226	3	3	40	1	0	0	0	0	1	0	0	0	5701	903	32	2	2305	2	FANCI	15	89836226	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	3713296	89836226	12695166	120	8619											
C16orf91	283951	broad.mit.edu	37	chr16	1478469	1478469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgagctgaggtccacctgcGcccgaagcctgggctggcca	6	5	14	16	3	0	1	0	1	0	0	1	3	1	1	6	3	3	2	6	3	1	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr16:1478469G>A	uc010uvd.1	-	2	182	c.182C>T	c.(181-183)GCG>GTG	p.A61V		NM_001010878	NP_001010878	Q4G0I0	CSMT1_HUMAN	hypothetical protein LOC283951	Error:Variant_position_missing_in_Q4G0I0_after_alignment						integral to membrane					0						GTCCACCTGCGCCCGAAGCCT	0.672													4	27					0	0	0	0	A	1478469	A	A	1478469	3	1	40	1	0	0	0	0	1	0	0	0	1850	1087	38	1	902	1	C16orf91	16	1478469	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08		1478469	88876284	121	8620											
UMOD	7369	broad.mit.edu	37	chr16	20352551	20352551	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgtagagaaaagcctcagtgGacagtgtcacggaggagcct	12	6	14	9	2	2	1	2	0	0	1	2	5	2	4	2	3	2	1	2	3	3	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr16:20352551G>A	uc002dgz.2	-	7	1568	c.1439C>T	c.(1438-1440)TCC>TTC	p.S480F	UMOD_uc002dha.2_Missense_Mutation_p.S480F|UMOD_uc002dhb.2_Missense_Mutation_p.S513F	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	480	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						AGCCTCAGTGGACAGTGTCAC	0.587													7	65					0	0	0	0	A	20352551	A	A	20352551	3	1	40	1	0	0	0	0	1	0	0	0	17047	1174	41	2	503	2	UMOD	16	20352551	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	18874082	20352551	70002202	122	8621											
ZNF771	51333	broad.mit.edu	37	chr16	30419501	30419501	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgaaactcaagatccccAtggacaacaaggaggtatgt	14	8	11	8	0	1	2	1	1	0	1	2	4	2	4	2	4	2	1	2	4	5	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr16:30419501A>G	uc002dyd.2	+	2	387	c.127A>G	c.(127-129)ATG>GTG	p.M43V	ZNF771_uc002dyc.2_RNA|ZNF771_uc010ver.1_Missense_Mutation_p.M43V|ZNF771_uc010bzx.2_RNA	NM_001142305	NP_001135777	Q7L3S4	ZN771_HUMAN	zinc finger protein 771	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.193)			CAAGATCCCCATGGACAACAA	0.333													8	79					0	0	0	0	G	30419501	G	G	30419501	3	3	40	1	0	0	0	0	1	0	0	0	18211	217	8	5	129	5	ZNF771	16	30419501	Missense_Mutation	SNP	A	TCGA-CN-4728-01A-01D-1434-08	10066950	30419501	59935252	123	8622											
ELMO3	79767	broad.mit.edu	37	chr16	67234439	67234439	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgggagactctgagcatcCcctttgtgaggaaggtgggt	7	10	15	9	0	1	3	0	2	1	1	2	5	2	4	3	4	1	1	3	4	1	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr16:67234439C>T	uc002esa.2	+	6	701	c.658C>T	c.(658-660)CCC>TCC	p.P220S	ELMO3_uc002esb.2_Missense_Mutation_p.P203S|ELMO3_uc002esc.2_Missense_Mutation_p.P54S	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	167					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		TCTGAGCATCCCCTTTGTGAG	0.647													14	109					0	0	0	0	T	67234439	T	T	67234439	3	4	40	1	0	0	0	0	1	0	0	0	5091	623	22	4	680	4	ELMO3	16	67234439	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	36814938	67234439	23120314	124	8623											
TSNAXIP1	55815	broad.mit.edu	37	chr16	67854801	67854801	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccacatacaccagtggccaGaccattttgcaaaatcgaaa	15	7	6	13	1	0	1	0	0	0	1	1	2	0	1	4	1	2	1	4	1	4	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr16:67854801G>C	uc002euj.2	+	3	439	c.45G>C	c.(43-45)CAG>CAC	p.Q15H	TSNAXIP1_uc010cep.2_5'UTR|TSNAXIP1_uc010vjz.1_Intron|TSNAXIP1_uc002euf.3_Intron|TSNAXIP1_uc010vka.1_Missense_Mutation_p.Q69H|TSNAXIP1_uc010vkb.1_Intron|TSNAXIP1_uc002eug.3_Intron|TSNAXIP1_uc002euh.3_Intron|TSNAXIP1_uc002eui.3_Intron|TSNAXIP1_uc002euk.2_5'Flank	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	15					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		CCAGTGGCCAGACCATTTTGC	0.577													41	489					0	0	0	0	C	67854801	C	C	67854801	3	2	40	1	0	0	0	0	1	0	0	0	16699	933	33	2	47	2	TSNAXIP1	16	67854801	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	620362	67854801	22499952	125	8624											
DULLARD	23399	broad.mit.edu	37	chr17	7150389	7150389	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccaccaccacacaccttgagGatgaagtcaggaggcgtacc	12	5	10	14	1	1	2	1	2	0	0	1	4	1	4	5	3	1	1	5	3	2	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr17:7150389G>C	uc002gfd.2	-	3	662	c.282C>G	c.(280-282)ATC>ATG	p.I94M	DULLARD_uc002gfe.2_Missense_Mutation_p.I94M|DULLARD_uc002gff.2_Missense_Mutation_p.I94M|DULLARD_uc002gfc.2_RNA	NM_001143775	NP_001137247	O95476	CNEP1_HUMAN	dullard homolog	94	FCP1 homology.				nuclear envelope organization|protein dephosphorylation	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein serine/threonine phosphatase activity				0						ACACCTTGAGGATGAAGTCAG	0.562													41	159					0	0	0	0	C	7150389	C	C	7150389	3	2	40	1	0	0	0	0	1	0	0	0	4821	1164	41	2	476	2	DULLARD	17	7150389	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08		7150389	74044821	126	8625											
TP53	7157	broad.mit.edu	37	chr17	7579514	7579514	+	Frame_Shift_Del	DEL	G	-	-																															tgggagcttcatctggacctGggtcttcagtgaaccattgt																								rs144386518		TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr17:7579514delG	uc002gim.2	-	4	367	c.173delC	c.(172-174)CCAfs	p.P58fs	TP53_uc002gig.1_Frame_Shift_Del_p.P58fs|TP53_uc002gih.2_Frame_Shift_Del_p.P58fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.P58fs|TP53_uc010cni.1_Frame_Shift_Del_p.P58fs|TP53_uc002gij.2_Frame_Shift_Del_p.P58fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.P19fs|TP53_uc010cnk.1_Frame_Shift_Del_p.P73fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	58	Interaction with HRMT1L2.		P -> T (in a sporadic cancer; somatic mutation).|P -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.P58L(1)|p.P58fs*65(1)|p.E51fs*59(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)|p.D57fs*86(1)|p.P58Q(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCTGGACCTGGGTCTTCAGT	0.602		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7579514	-	-	7579514	7	5	40	1	0	1	0	1	0	0	0	0	16448	1348	47	0	1129	0	TP53	17	7579514	Frame_Shift_Del	DEL	G	TCGA-CN-4728-01A-01D-1434-08	429125	7579514	73615696	127	8626											
RICH2	9912	broad.mit.edu	37	chr17	12812249	12812249	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaacactggctcagtgtctGatggaggggtcagctatcct	9	10	12	10	0	3	1	2	1	1	0	4	2	4	2	1	4	2	2	1	4	2	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr17:12812249G>C	uc002gnr.3	+	4	561	c.234G>C	c.(232-234)CTG>CTC	p.L78L	RICH2_uc010vvk.1_Silent_p.L78L|RICH2_uc010vvl.1_Silent_p.L78L|RICH2_uc002gns.3_5'UTR|RICH2_uc010vvm.1_Silent_p.L78L|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	78	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						CTCAGTGTCTGATGGAGGGGT	0.428													21	337					0	0	0	0	C	12812249	C	C	12812249	2	2	40	1	0	0	0	0	0	0	0	1	13422	1277	45	2		2	RICH2	17	12812249	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	5232735	12812249	68382961	128	8627											
SUZ12	23512	broad.mit.edu	37	chr17	30321584	30321584	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttacatttttgttgcagtAtcatccaaaaggtgctagga	11	16	8	6	0	1	0	1	0	0	0	2	1	2	1	1	2	3	4	1	2	5	7			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr17:30321584A>G	uc002hgs.2	+	13	1661	c.1439A>G	c.(1438-1440)TAT>TGT	p.Y480C	SUZ12_uc002hgt.2_Missense_Mutation_p.Y457C	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	480					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				TTGTTGCAGTATCATCCAAAA	0.323			T	JAZF1	endometrial stromal tumours								7	75					0	0	0	0	G	30321584	G	G	30321584	3	3	40	1	0	0	0	0	1	0	0	0	15482	463	16	5	1489	5	SUZ12	17	30321584	Missense_Mutation	SNP	A	TCGA-CN-4728-01A-01D-1434-08	17509335	30321584	50873626	129	8628											
HOXB3	3213	broad.mit.edu	37	chr17	46627999	46627999	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgttggcttggaggacgtgCggctcatactcgggcgccgg	4	8	17	12	6	1	0	1	0	0	0	2	2	1	2	2	6	2	3	2	6	1	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr17:46627999C>T	uc002inn.2	-	2	1393	c.993G>A	c.(991-993)CCG>CCA	p.P331P	HOXB3_uc010wlm.1_Silent_p.P258P|HOXB3_uc010dbf.2_Silent_p.P331P|HOXB3_uc010dbg.2_Silent_p.P331P|HOXB3_uc002ino.2_Silent_p.P331P|HOXB3_uc010wlk.1_Silent_p.P199P|HOXB3_uc010wll.1_Silent_p.P258P	NM_002146	NP_002137	P14651	HXB3_HUMAN	homeobox B3	331					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGAGGACGTGCGGCTCATACT	0.716											OREG0024516	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	70					0	0	0	0	T	46627999	T	T	46627999	2	4	40	1	0	0	0	0	0	0	0	1	7341	755	27	1		1	HOXB3	17	46627999	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	16306415	46627999	34567211	130	8629											
PTRH2	51651	broad.mit.edu	37	chr17	57775074	57775074	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcttgtaggctgaaacagcaGcatgagagcactgggcagcc	11	6	14	10	0	0	2	0	2	0	1	0	3	0	2	1	2	5	7	1	2	2	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr17:57775074G>A	uc002ixt.2	-	2	391	c.266C>T	c.(265-267)GCT>GTT	p.A89V	PTRH2_uc002ixs.2_RNA	NM_016077	NP_057161	Q9Y3E5	PTH2_HUMAN	Bcl-2 inhibitor of transcription precursor	89					apoptosis|translation	mitochondrion	aminoacyl-tRNA hydrolase activity				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TGAAACAGCAGCATGAGAGCA	0.478													35	251					0	0	0	0	A	57775074	A	A	57775074	3	1	40	1	0	0	0	0	1	0	0	0	12882	971	34	4	277	4	PTRH2	17	57775074	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	11147075	57775074	23420136	131	8630											
CYB561	1534	broad.mit.edu	37	chr17	61511870	61511870	+	Frame_Shift_Del	DEL	A	-	-																															gtcggcccgggtcaagatgtAgagcaccgccccaccgaagc																										TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr17:61511870delA	uc002jap.2	-	5	1051	c.649delT	c.(649-651)TACfs	p.Y217fs	CYB561_uc002jaq.2_Frame_Shift_Del_p.Y263fs|CYB561_uc002jar.2_Frame_Shift_Del_p.Y217fs|CYB561_uc002jas.2_Frame_Shift_Del_p.Y217fs|CYB561_uc010ddt.2_3'UTR|CYB561_uc002jat.2_Frame_Shift_Del_p.Y217fs|CYB561_uc010wpf.1_3'UTR|CYB561_uc010wpg.1_Frame_Shift_Del_p.Y188fs	NM_001915	NP_001906	P49447	CY561_HUMAN	cytochrome b-561	217	Cytochrome b561.|Helical; (Potential).				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(1115;0.0689)		GTCAAGATGTAGAGCACCGCC	0.657													---	---	---								-	61511870	-	-	61511870	7	5	40	1	0	1	0	1	0	0	0	0	4136	420	15	0	110	0	CYB561	17	61511870	Frame_Shift_Del	DEL	A	TCGA-CN-4728-01A-01D-1434-08	3736796	61511870	19683340	132	8631											
PITPNC1	26207	broad.mit.edu	37	chr17	65688860	65688860	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctctccacagacgcaccCgaatttctgtccgttcccaa	8	10	5	18	3	2	1	0	0	2	1	6	2	5	1	5	0	0	2	5	0	2	2	rs146560406	by1000genomes	TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr17:65688860C>T	uc002jgc.2	+	9	1202	c.855C>T	c.(853-855)CCC>CCT	p.P285P	PITPNC1_uc002jgb.2_3'UTR	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	285					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			CAGACGCACCCGAATTTCTGT	0.557													7	170					0	0	0	0	T	65688860	T	T	65688860	2	4	40	1	0	0	0	0	0	0	0	1	12004	639	23	1		1	PITPNC1	17	65688860	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	4176990	65688860	15506350	133	8632											
ABCA7	10347	broad.mit.edu	37	chr19	1043251	1043251	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgccagacagcagcctgaGtgagtgactgacctcggttt	8	9	12	12	1	0	5	0	4	0	1	1	5	0	5	4	1	3	2	4	1	0	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:1043251G>A	uc002lqw.3	+	8	1021	c.790_splice	c.e8+1	p.S264_splice	ABCA7_uc010dsb.1_Splice_Site_p.S126_splice	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7						phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCAGCCTGAGTGAGTGACTG	0.657													17	168					0	0	0	0	A	1043251	A	A	1043251	5	1	40	1	0	0	0	0	0	0	1	0	37	1043	36	4	817	4	ABCA7	19	1043251	Splice_Site	SNP	G	TCGA-CN-4728-01A-01D-1434-08		1043251	58085732	134	8633											
MPND	84954	broad.mit.edu	37	chr19	4345805	4345805	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggcaggagaccgggcagAccttcaactcacccagcgcc	9	5	12	15	2	2	2	2	0	0	2	2	3	2	2	4	3	2	2	4	3	1	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:4345805A>T	uc002mae.2	+	3	425	c.358A>T	c.(358-360)ACC>TCC	p.T120S	MPND_uc010dtx.2_RNA|MPND_uc002mag.2_Missense_Mutation_p.T120S|MPND_uc002maf.2_Missense_Mutation_p.T120S|MPND_uc002mah.2_Missense_Mutation_p.T8S|MPND_uc002mai.2_Missense_Mutation_p.T8S	NM_032868	NP_116257	Q8N594	MPND_HUMAN	MPN domain containing isoform 1	120							peptidase activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GACCGGGCAGACCTTCAACTC	0.622													9	86					0	0	0	0	T	4345805	T	T	4345805	3	4	40	1	0	0	0	0	1	0	0	0	9784	275	10	5	368	5	MPND	19	4345805	Missense_Mutation	SNP	A	TCGA-CN-4728-01A-01D-1434-08	3302554	4345805	54783178	135	8634											
MPND	84954	broad.mit.edu	37	chr19	4357346	4357346	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catctctgcaggacatcgacGcacagatggactaccagctg	11	7	10	13	2	1	1	0	0	1	1	3	4	1	3	1	2	3	3	1	2	1	1	rs61730129		TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:4357346G>A	uc002mae.2	+	9	1160	c.1093G>A	c.(1093-1095)GCA>ACA	p.A365T	MPND_uc010dtx.2_RNA|MPND_uc002mag.2_Missense_Mutation_p.A315T|MPND_uc002maf.2_Missense_Mutation_p.A365T|MPND_uc002mah.2_Missense_Mutation_p.A253T|MPND_uc002mai.2_Missense_Mutation_p.A224T	NM_032868	NP_116257	Q8N594	MPND_HUMAN	MPN domain containing isoform 1	365	MPN.						peptidase activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACATCGACGCACAGATGGA	0.672													9	41					0	0	0	0	A	4357346	A	A	4357346	3	1	40	1	0	0	0	0	1	0	0	0	9784	1087	38	1	1127	1	MPND	19	4357346	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	11541	4357346	54771637	136	8635											
RFX1	5989	broad.mit.edu	37	chr19	14079491	14079491	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcttctggatgggcttgaGcctggagtagaatgggcagg	8	10	16	7	0	2	2	0	1	2	1	2	4	2	4	1	5	1	3	1	5	2	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:14079491G>T	uc002mxv.2	-	12	1890	c.1618C>A	c.(1618-1620)CTC>ATC	p.L540I		NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	540					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			ATGGGCTTGAGCCTGGAGTAG	0.692													6	52					2.7689e-08	3.2139e-08	1	0	T	14079491	T	T	14079491	3	4	40	1	0	0	0	0	1	0	0	0	13327	985	34	4	1361	4	RFX1	19	14079491	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	9722145	14079491	45049492	137	8636											
MED26	9441	broad.mit.edu	37	chr19	16687957	16687957	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcccggggagctggtgtgCggtcgcacggcgttgacggg	4	6	21	10	6	0	1	0	1	0	0	1	2	0	2	1	7	2	3	1	7	0	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:16687957C>T	uc002nen.1	-	3	945	c.684G>A	c.(682-684)CCG>CCA	p.P228P	MED26_uc002nee.2_RNA	NM_004831	NP_004822	O95402	MED26_HUMAN	mediator complex subunit 26	228	Pro-rich.				regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			ovary(2)	2						AGCTGGTGTGCGGTCGCACGG	0.682													8	113					0	0	0	0	T	16687957	T	T	16687957	2	4	40	1	0	0	0	0	0	0	0	1	9497	755	27	1		1	MED26	19	16687957	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	2608466	16687957	42441026	138	8637											
LSR	51599	broad.mit.edu	37	chr19	35758624	35758624	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcgcaggcgtcccgagagcGcaggctcaagaaggtgaggg	9	4	17	11	4	1	3	1	1	0	2	3	4	2	3	1	4	1	3	1	4	2	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:35758624G>A	uc002nyl.2	+	9	2124	c.1901G>A	c.(1900-1902)CGC>CAC	p.R634H	LSR_uc002nym.2_Missense_Mutation_p.R615H|LSR_uc002nyn.2_Missense_Mutation_p.R566H|LSR_uc002nyo.2_Missense_Mutation_p.R614H|LSR_uc010xsr.1_Missense_Mutation_p.R526H|LSR_uc002nyp.2_Missense_Mutation_p.R576H|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank|USF2_uc002nyv.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	634	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TCCCGAGAGCGCAGGCTCAAG	0.567													4	151					0	0	0	0	A	35758624	A	A	35758624	3	1	40	1	0	0	0	0	1	0	0	0	9114	1087	38	1	1935	1	LSR	19	35758624	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	19070667	35758624	23370359	139	8638											
SUPT5H	6829	broad.mit.edu	37	chr19	39964120	39964120	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagccgcactcctgcccaGagtggggcctgggaccccaa	7	4	14	16	1	0	1	0	0	0	1	1	2	1	2	6	4	2	2	6	4	1	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:39964120G>C	uc002olo.3	+	25	2630	c.2451G>C	c.(2449-2451)CAG>CAC	p.Q817H	SUPT5H_uc002olp.3_Missense_Mutation_p.Q817H|SUPT5H_uc002olq.3_Missense_Mutation_p.Q813H|SUPT5H_uc002oln.3_Missense_Mutation_p.Q817H|SUPT5H_uc002olr.3_Missense_Mutation_p.Q817H|SUPT5H_uc002ols.1_Missense_Mutation_p.Q440H|SUPT5H_uc010egp.1_3'UTR	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	817	CTR1-9.|9 X 7 AA approximate tandem repeats of G- S-[QR]-T-P-X-[YQ], motif CTR1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CTCCTGCCCAGAGTGGGGCCT	0.632													13	107					0	0	0	0	C	39964120	C	C	39964120	3	2	40	1	0	0	0	0	1	0	0	0	15465	933	33	2	2545	2	SUPT5H	19	39964120	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	4205496	39964120	19164863	140	8639											
RPS19	6223	broad.mit.edu	37	chr19	42373230	42373230	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctccaagagtgtggcccGccgggtcctccaagccctgg	6	6	14	15	2	0	1	0	0	0	1	3	1	3	1	6	4	1	1	6	4	2	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:42373230G>A	uc002ort.2	+	4	674	c.302G>A	c.(301-303)CGC>CAC	p.R101H		NM_001022	NP_001013	P39019	RS19_HUMAN	ribosomal protein S19	101			R -> H (in DBA1; increased protein degradation; affects assembly into a functional ribosomal subunit).		endocrine pancreas development|erythrocyte differentiation|gas transport|positive regulation of cellular component movement|response to extracellular stimulus|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						AGTGTGGCCCGCCGGGTCCTC	0.617									Diamond-Blackfan_Anemia				6	59					0	0	0	0	A	42373230	A	A	42373230	3	1	40	1	0	0	0	0	1	0	0	0	13694	1087	38	1	312	1	RPS19	19	42373230	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	2409110	42373230	16755753	141	8640											
ZNF574	64763	broad.mit.edu	37	chr19	42583864	42583864	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacttcctgtgtgtagactGtggcctggccttcggcacag	6	11	12	12	1	0	1	0	0	0	1	2	1	1	1	3	3	0	2	3	3	1	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:42583864G>T	uc002osm.3	+	2	1275	c.1106G>T	c.(1105-1107)TGT>TTT	p.C369F	ZNF574_uc002osk.3_Missense_Mutation_p.C459F	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	369	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				TGTGTAGACTGTGGCCTGGCC	0.592													8	96					0.000274275	0.000298791	1	0	T	42583864	T	T	42583864	3	4	40	1	0	0	0	0	1	0	0	0	18073	1377	48	4	1108	4	ZNF574	19	42583864	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	210634	42583864	16545119	142	8641											
PSG4	5672	broad.mit.edu	37	chr19	43699348	43699348	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagttcttactcttaggttCacaggtgaaggttaagacat	11	14	10	6	0	3	2	1	1	2	1	3	2	3	2	0	3	1	4	0	3	5	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:43699348C>T	uc002ovy.2	-	4	889	c.787G>A	c.(787-789)GAA>AAA	p.E263K	PSG6_uc010xwk.1_Intron|PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.E170K|PSG4_uc002ovz.2_Intron	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	263	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				CTCTTAGGTTCACAGGTGAAG	0.453													39	416					0	0	0	0	T	43699348	T	T	43699348	3	4	40	1	0	0	0	0	1	0	0	0	12719	835	29	2	484	2	PSG4	19	43699348	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	1115484	43699348	15429635	143	8642											
ERCC2	2068	broad.mit.edu	37	chr19	45860923	45860923	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttggcaatggtcggggtTctgtcgtcaaagggctcgat	6	11	17	7	3	2	0	1	0	1	0	5	1	2	0	0	6	0	4	0	6	2	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:45860923T>C	uc002pbj.2	-	13	1319	c.1272A>G	c.(1270-1272)AGA>AGG	p.R424R	ERCC2_uc002pbh.2_5'UTR|ERCC2_uc002pbi.2_Silent_p.R117R|ERCC2_uc010ejz.2_Silent_p.R346R|ERCC2_uc002pbk.2_Silent_p.R400R	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	424					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TGGTCGGGGTTCTGTCGTCAA	0.637			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				8	65					0	0	0	0	C	45860923	C	C	45860923	2	2	40	1	0	0	0	0	0	0	0	1	5237	1780	62	5		5	ERCC2	19	45860923	Silent	SNP	T	TCGA-CN-4728-01A-01D-1434-08	2161575	45860923	13268060	144	8643											
ZC3H4	23211	broad.mit.edu	37	chr19	47588318	47588318	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggagtcaactcacgcccaTgtcctcgtcatagaagtctt	9	11	9	12	2	4	1	3	0	1	1	6	2	5	2	2	1	1	0	2	1	3	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:47588318T>C	uc002pga.3	-	8	1140	c.1102A>G	c.(1102-1104)ATG>GTG	p.M368V	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	368	Gly-rich.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CTCACGCCCATGTCCTCGTCA	0.532													56	331					0	0	0	0	C	47588318	C	C	47588318	3	2	40	1	0	0	0	0	1	0	0	0	17637	1464	51	5	2841	5	ZC3H4	19	47588318	Missense_Mutation	SNP	T	TCGA-CN-4728-01A-01D-1434-08	1727395	47588318	11540665	145	8644											
RASIP1	54922	broad.mit.edu	37	chr19	49224087	49224087	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccacgggaggcccatggcGataattggctggcagctcct	7	7	15	12	2	0	0	0	0	0	0	1	2	1	1	3	6	1	3	3	6	1	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:49224087G>A	uc002pki.2	-	12	3057	c.2860C>T	c.(2860-2862)CGC>TGC	p.R954C	MAMSTR_uc002pkg.2_5'Flank|RASIP1_uc002pkh.2_Missense_Mutation_p.R215C	NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	954					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GGCCCATGGCGATAATTGGCT	0.612													12	246					0	0	0	0	A	49224087	A	A	49224087	3	1	40	1	0	0	0	0	1	0	0	0	13143	1058	37	1	35	1	RASIP1	19	49224087	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	1635769	49224087	9904896	146	8645											
ZNF473	25888	broad.mit.edu	37	chr19	50549541	50549541	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaccatcaaagaatccactCtagagtgaggctgtataaat	15	10	7	9	0	3	3	2	1	1	2	4	3	4	3	2	1	0	2	2	1	6	3			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:50549541C>G	uc002prn.2	+	5	2078	c.1841C>G	c.(1840-1842)TCT>TGT	p.S614C	ZNF473_uc002prm.2_Missense_Mutation_p.S614C|ZNF473_uc010ybo.1_Missense_Mutation_p.S602C	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	614					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		AGAATCCACTCTAGAGTGAGG	0.488													7	74					0	0	0	0	G	50549541	G	G	50549541	3	3	40	1	0	0	0	0	1	0	0	0	17998	913	32	2	1855	2	ZNF473	19	50549541	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	1325454	50549541	8579442	147	8646											
PPP2R1A	5518	broad.mit.edu	37	chr19	52724304	52724305	+	Frame_Shift_Ins	INS	-	T	T																															tttgggaaggagtgggcccaINStgccacaatcatccccaagg																								rs141690261		TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:52724304_52724305insT	uc002pyp.2	+	12	1595_1596	c.1436_1437insT	c.(1435-1437)CATfs	p.H479fs	PPP2R1A_uc010ydk.1_Frame_Shift_Ins_p.H424fs|PPP2R1A_uc002pyq.2_Frame_Shift_Ins_p.H300fs	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	479	PP2A subunit C binding.|HEAT 13.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GAGTGGGCCCATGCCACAATCA	0.559			Mis		clear cell ovarian carcinoma								---	---	---								T	52724305	T	T	52724304	7	5	40	1	0	1	1	0	0	0	0	0	12442	217	8	0	1482	0	PPP2R1A	19	52724304	Frame_Shift_Ins	INS	-	TCGA-CN-4728-01A-01D-1434-08	2174763	52724304	6404679	148	8647											
ZFP28	140612	broad.mit.edu	37	chr19	57065936	57065936	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccttttaagtgtaaagagtgCggaaaagcttttaggcagaa	14	11	11	5	1	0	2	0	0	0	2	0	3	0	3	1	2	2	3	1	2	7	5	rs61734808	byFrequency	TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:57065936C>T	uc002qnj.2	+	8	1853	c.1782C>T	c.(1780-1782)TGC>TGT	p.C594C	uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	594	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		GTAAAGAGTGCGGAAAAGCTT	0.413													4	238					0	0	0	0	T	57065936	T	T	57065936	2	4	40	1	0	0	0	0	0	0	0	1	17709	776	27	1		1	ZFP28	19	57065936	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	4341632	57065936	2063047	149	8648											
ZNF606	80095	broad.mit.edu	37	chr19	58489924	58489924	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcccacattcattacacctGtatggtttctctccagtatg	8	16	5	12	0	2	0	1	0	1	0	5	0	4	0	3	1	1	3	3	1	3	6			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:58489924G>A	uc002qqw.2	-	7	2742	c.2124C>T	c.(2122-2124)TAC>TAT	p.Y708Y	ZNF606_uc010yhp.1_Silent_p.Y618Y	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	708	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		CATTACACCTGTATGGTTTCT	0.393													23	147					0	0	0	0	A	58489924	A	A	58489924	2	1	40	1	0	0	0	0	0	0	0	1	18099	1372	48	4		4	ZNF606	19	58489924	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	1423988	58489924	639059	150	8649											
ZNF329	79673	broad.mit.edu	37	chr19	58639690	58639690	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcatagggtttctccccaGaatggatcttttgatgcaca	10	14	8	9	0	3	2	1	1	2	1	4	3	3	3	2	2	1	2	2	2	2	5			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:58639690G>A	uc002qrn.2	-	4	1418	c.1181C>T	c.(1180-1182)TCT>TTT	p.S394F	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TTTCTCCCCAGAATGGATCTT	0.468													18	177					0	0	0	0	A	58639690	A	A	58639690	3	1	40	1	0	0	0	0	1	0	0	0	17914	942	33	2	448	2	ZNF329	19	58639690	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	149766	58639690	489293	151	8650											
ZSCAN22	342945	broad.mit.edu	37	chr19	58849700	58849700	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagagccatcaaatgtcactGagaccctcatgggaggtgtt	11	9	11	10	0	3	2	3	1	0	2	3	4	3	3	2	2	1	1	2	2	1	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr19:58849700G>C	uc002qsc.2	+	3	631	c.484G>C	c.(484-486)GAG>CAG	p.E162Q	ZSCAN22_uc010yhz.1_Silent_p.L156L	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	162					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		AAATGTCACTGAGACCCTCAT	0.567													13	141					0	0	0	0	C	58849700	C	C	58849700	3	2	40	1	0	0	0	0	1	0	0	0	18301	1291	45	2	490	2	ZSCAN22	19	58849700	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	210010	58849700	279283	152	8651											
MKKS	8195	broad.mit.edu	37	chr20	10393770	10393770	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaccacaggtctcagacttGagataactgatgcaaagact	15	8	8	10	0	1	4	1	2	1	3	2	5	1	4	1	1	3	1	1	1	3	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr20:10393770G>C	uc002wnt.1	-	3	1280	c.393C>G	c.(391-393)CTC>CTG	p.L131L	MKKS_uc002wnu.1_Silent_p.L131L|MKKS_uc010zrd.1_Intron	NM_018848	NP_061336	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome protein	131					brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding				0						TCTCAGACTTGAGATAACTGA	0.398									Bardet-Biedl_syndrome				5	87					0	0	0	0	C	10393770	C	C	10393770	2	2	40	1	0	0	0	0	0	0	0	1	9653	1277	45	2		2	MKKS	20	10393770	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08		10393770	52631750	153	8652			3	11		3	3	202	G		5.637248e-07
MKKS	8195	broad.mit.edu	37	chr20	10393844	10393844	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtgtcaagcctaatctctGaacattttcaatcaggttgc	10	13	9	9	0	4	1	3	1	1	0	5	1	4	1	1	2	3	1	1	2	4	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr20:10393844G>C	uc002wnt.1	-	3	1206	c.319C>G	c.(319-321)CAG>GAG	p.Q107E	MKKS_uc002wnu.1_Missense_Mutation_p.Q107E|MKKS_uc010zrd.1_Intron	NM_018848	NP_061336	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome protein	107					brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding				0						CCTAATCTCTGAACATTTTCA	0.393									Bardet-Biedl_syndrome				10	90					0	0	0	0	C	10393844	C	C	10393844	3	2	40	1	0	0	0	0	1	0	0	0	9653	1299	45	2	1409	2	MKKS	20	10393844	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	74	10393844	52631676	154	8653			3	11		3	3	202	G		5.637248e-07
MKKS	8195	broad.mit.edu	37	chr20	10393971	10393971	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgtgaccaaaaggtgactGagcagagctgaggactgtga	12	8	15	6	0	0	6	0	5	0	1	0	7	0	7	1	2	2	2	1	2	2	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr20:10393971G>C	uc002wnt.1	-	3	1079	c.192C>G	c.(190-192)CTC>CTG	p.L64L	MKKS_uc002wnu.1_Silent_p.L64L|MKKS_uc010zrd.1_Intron	NM_018848	NP_061336	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome protein	64					brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding				0						AAAGGTGACTGAGCAGAGCTG	0.468									Bardet-Biedl_syndrome				10	112					0	0	0	0	C	10393971	C	C	10393971	2	2	40	1	0	0	0	0	0	0	0	1	9653	1277	45	2		2	MKKS	20	10393971	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	127	10393971	52631549	155	8654			3	11		3	3	202	G		5.637248e-07
L3MBTL	26013	broad.mit.edu	37	chr20	42144745	42144745	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctacaggagaagcaagaaGaaggaaaggacccagaggga	18	3	14	6	0	1	4	0	0	1	4	1	8	1	7	1	4	2	1	1	4	6	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr20:42144745G>C	uc010zwh.1	+	7	770	c.724G>C	c.(724-726)GAA>CAA	p.E242Q	L3MBTL_uc010ggk.1_Missense_Mutation_p.E174Q|L3MBTL_uc002xkl.2_Missense_Mutation_p.E174Q|L3MBTL_uc002xkm.2_Missense_Mutation_p.E174Q|L3MBTL_uc010ggl.2_Missense_Mutation_p.E174Q	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	174					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GAAGCAAGAAGAAGGAAAGGA	0.552													5	73					0	0	0	0	C	42144745	C	C	42144745	3	2	40	1	0	0	0	0	1	0	0	0	8631	943	33	2	534	2	L3MBTL	20	42144745	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	31750774	42144745	20880775	156	8655											
HNF4A	3172	broad.mit.edu	37	chr20	43030122	43030122	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgtgcaggtgttgacgatggGcaatggtaggtgggggcaga	8	9	20	4	1	0	2	0	1	0	1	0	3	0	2	0	6	1	5	0	6	2	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr20:43030122G>A	uc002xma.2	+	1	199	c.110G>A	c.(109-111)GGC>GAC	p.G37D	HNF4A_uc010zwo.1_Intron|HNF4A_uc002xlt.2_Intron|HNF4A_uc002xlu.2_Intron|HNF4A_uc002xlv.2_Intron|uc002xlw.1_Intron|HNF4A_uc002xly.2_Missense_Mutation_p.G37D|HNF4A_uc002xlz.2_Missense_Mutation_p.G37D|HNF4A_uc010ggq.2_5'UTR	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	37					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TTGACGATGGGCAATGGTAGG	0.587													10	96					0	0	0	0	A	43030122	A	A	43030122	3	1	40	1	0	0	0	0	1	0	0	0	7292	1203	42	4	165	4	HNF4A	20	43030122	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	885377	43030122	19995398	157	8656											
SLPI	6590	broad.mit.edu	37	chr20	43882277	43882277	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagtgtcaggacaacatctCttcttccctggacactgcca	10	10	7	14	0	3	0	1	0	2	0	5	2	4	2	2	2	2	0	2	2	2	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr20:43882277C>T	uc002xnm.1	-	2	205	c.183G>A	c.(181-183)AAG>AAA	p.K61K		NM_003064	NP_003055	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	61	Trypsin inhibitory domain.|WAP 1.					extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GACAACATCTCTTCTTCCCTG	0.517													5	74					0	0	0	0	T	43882277	T	T	43882277	2	4	40	1	0	0	0	0	0	0	0	1	14817	912	32	2		2	SLPI	20	43882277	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08	852155	43882277	19143243	158	8657											
TFAP2C	7022	broad.mit.edu	37	chr20	55208539	55208540	+	Frame_Shift_Ins	INS	-	T	T																															tcctcagctctacgtctaaaINStacaaagtgacagtggctga																										TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr20:55208539_55208540insT	uc002xya.2	+	4	960_961	c.717_718insT	c.(715-720)AAATACfs	p.K239fs	TFAP2C_uc010zzi.1_Frame_Shift_Ins_p.K70fs	NM_003222	NP_003213	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma	239_240					cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Colorectal(105;0.229)			CTACGTCTAAATACAAAGTGAC	0.535													---	---	---								T	55208540	T	T	55208539	7	5	40	1	0	1	1	0	0	0	0	0	15855	98	4	0	731	0	TFAP2C	20	55208539	Frame_Shift_Ins	INS	-	TCGA-CN-4728-01A-01D-1434-08	11326262	55208539	7816981	159	8658											
PES1	23481	broad.mit.edu	37	chr22	30985250	30985250	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtagttggtggccgagcctCgttcatactgggagaggaaa	9	10	15	7	2	1	1	1	0	0	1	2	4	1	2	2	4	2	3	2	4	3	4			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr22:30985250C>T	uc003aij.1	-	2	106	c.32G>A	c.(31-33)CGA>CAA	p.R11Q	PES1_uc003aik.1_Missense_Mutation_p.R11Q|PES1_uc003ail.1_Missense_Mutation_p.R11Q|PES1_uc003aim.1_Missense_Mutation_p.R11Q|PES1_uc003ain.1_5'UTR|PES1_uc003aio.1_5'UTR	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	11	Sufficient for nucleolar localization.|Required for 28S ribosomal RNA processing.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						GGCCGAGCCTCGTTCATACTG	0.498													4	49					0	0	0	0	T	30985250	T	T	30985250	3	4	40	1	0	0	0	0	1	0	0	0	11787	884	31	1	1790	1	PES1	22	30985250	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08		30985250	20319316	160	8659											
MYH9	4627	broad.mit.edu	37	chr22	36712581	36712581	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catcaaagatctcgaagccgGcaatgtccaggatcccgatg	12	7	10	12	3	2	1	1	0	1	1	5	4	4	2	3	2	1	1	3	2	3	0			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chr22:36712581G>A	uc003apg.2	-	12	1592	c.1361C>T	c.(1360-1362)GCC>GTC	p.A454V	MYH9_uc003aph.1_Missense_Mutation_p.A318V	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	454	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CTCGAAGCCGGCAATGTCCAG	0.562			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				4	236					0	0	0	0	A	36712581	A	A	36712581	3	1	40	1	0	0	0	0	1	0	0	0	10095	1203	42	4	4641	4	MYH9	22	36712581	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	5727331	36712581	14591985	161	8660											
P2RY10	27334	broad.mit.edu	37	chrX	78217001	78217001	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgtgacccgctcccgcctCatgagcaaggagagtggttc	7	9	12	13	2	2	3	1	2	1	1	4	4	3	3	3	2	1	3	3	2	1	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chrX:78217001C>T	uc004ede.2	+	4	1353	c.984C>T	c.(982-984)CTC>CTT	p.L328L	P2RY10_uc004edf.2_Silent_p.L328L	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	328	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						GCTCCCGCCTCATGAGCAAGG	0.438													18	119					0	0	0	0	T	78217001	T	T	78217001	2	4	40	1	0	0	0	0	0	0	0	1	11401	813	29	2		2	P2RY10	23	78217001	Silent	SNP	C	TCGA-CN-4728-01A-01D-1434-08		78217001	77053559	162	8661											
CLDN2	9075	broad.mit.edu	37	chrX	106171760	106171760	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgcattatctctgtggtggGcatgagatgcacagtcttct	7	14	11	9	0	3	1	0	1	3	1	4	2	3	1	0	2	2	3	0	2	1	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chrX:106171760G>C	uc004emq.1	+	2	821	c.302G>C	c.(301-303)GGC>GCC	p.G101A	MORC4_uc004emp.3_Intron|CLDN2_uc004emt.1_Missense_Mutation_p.G101A	NM_020384	NP_065117	P57739	CLD2_HUMAN	claudin 2	101	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						TCTGTGGTGGGCATGAGATGC	0.572													16	96					0	0	0	0	C	106171760	C	C	106171760	3	2	40	1	0	0	0	0	1	0	0	0	3496	1203	42	4	304	4	CLDN2	23	106171760	Missense_Mutation	SNP	G	TCGA-CN-4728-01A-01D-1434-08	27954759	106171760	49098800	163	8662											
SLC25A5	292	broad.mit.edu	37	chrX	118604391	118604391	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcagctggatgatcgcacaGactgtcactgctgttgccgg	8	10	12	11	2	2	2	2	1	0	1	3	3	2	3	1	2	3	4	1	2	0	1			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chrX:118604391G>A	uc004erh.3	+	3	770	c.654G>A	c.(652-654)CAG>CAA	p.Q218Q	LOC100303728_uc004ere.1_5'Flank|LOC100303728_uc004erg.1_5'Flank	NM_001152	NP_001143	P05141	ADT2_HUMAN	adenine nucleotide translocator 2	218	Helical; Name=5; (By similarity).|Solcar 3.				chromosome segregation|energy reserve metabolic process|interspecies interaction between organisms|regulation of insulin secretion|viral reproduction	integral to plasma membrane|mitochondrial inner membrane|mitochondrial nucleoid|MMXD complex	adenine transmembrane transporter activity|protein binding			ovary(1)	1					Clodronate(DB00720)	TGATCGCACAGACTGTCACTG	0.488													15	72					0	0	0	0	A	118604391	A	A	118604391	2	1	40	1	0	0	0	0	0	0	0	1	14576	933	33	2		2	SLC25A5	23	118604391	Silent	SNP	G	TCGA-CN-4728-01A-01D-1434-08	12432631	118604391	36666169	164	8663											
AFF2	2334	broad.mit.edu	37	chrX	147743550	147743550	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgggaattccaaagaattCtgtgccccagaatcccaaca	14	8	8	11	0	1	2	0	0	1	2	3	3	3	3	4	1	2	0	4	1	5	2			TCGA-CN-4728-01A-01D-1434-08	TCGA-CN-4728-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	e450fec8-66dd-4798-8197-4206b8ba7c4d	4b1d7980-d6aa-4c96-b019-228d9243d7be	g.chrX:147743550C>A	uc004fcp.2	+	3	781	c.302C>A	c.(301-303)TCT>TAT	p.S101Y	AFF2_uc004fco.2_Missense_Mutation_p.S97Y|AFF2_uc004fcq.2_Missense_Mutation_p.S97Y|AFF2_uc004fcr.2_Missense_Mutation_p.S97Y|AFF2_uc011mxb.1_Missense_Mutation_p.S101Y|AFF2_uc004fcs.2_Missense_Mutation_p.S97Y	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	101					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CCAAAGAATTCTGTGCCCCAG	0.403													29	170					7.38237e-10	8.83167e-10	1	0	A	147743550	A	A	147743550	3	1	40	1	0	0	0	0	1	0	0	0	357	913	32	2	312	2	AFF2	23	147743550	Missense_Mutation	SNP	C	TCGA-CN-4728-01A-01D-1434-08	29139159	147743550	7527010	165	8664											
AJAP1	55966	broad.mit.edu	37	chr1	4832510	4832510	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcacgagtgcgtcagggCatctgtgcccgtgtacaccg	6	10	12	13	4	3	0	2	0	2	0	4	1	3	0	2	1	3	2	2	1	1	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:4832510C>T	uc001alm.1	+	4	1469	c.1088C>T	c.(1087-1089)GCA>GTA	p.A363V	AJAP1_uc001aln.2_Missense_Mutation_p.A363V	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	363	Targeting signals.|Cytoplasmic (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		TGCGTCAGGGCATCTGTGCCC	0.587													7	52					0	0	0	0	T	4832510	T	T	4832510	3	4	41	1	0	0	0	0	1	0	0	0	438	710	25	4	1102	4	AJAP1	1	4832510	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08		4832510	244418111	1	8665											
PRAMEF12	390999	broad.mit.edu	37	chr1	12835290	12835290	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactgcttgcccagaaggttCgccccaggtgaggtgaccca	8	7	12	14	1	0	3	0	2	0	1	1	3	0	3	4	3	2	2	4	3	1	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:12835290C>T	uc001aui.2	+	1	307	c.280C>T	c.(280-282)CGC>TGC	p.R94C		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	94										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGAAGGTTCGCCCCAGGTG	0.592													34	94					0	0	0	0	T	12835290	T	T	12835290	3	4	41	1	0	0	0	0	1	0	0	0	12488	884	31	1	282	1	PRAMEF12	1	12835290	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	8002780	12835290	236415331	2	8666											
PADI3	51702	broad.mit.edu	37	chr1	17603133	17603133	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatgtggatgagtttctgaGctttgtccctgcccccgatg	5	13	11	12	1	1	2	0	2	1	0	2	4	2	3	4	1	2	2	4	1	0	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:17603133G>T	uc001bai.2	+	12	1467	c.1427G>T	c.(1426-1428)AGC>ATC	p.S476I		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	476					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GAGTTTCTGAGCTTTGTCCCT	0.607													11	124					2.80697e-09	2.99802e-09	1	0	T	17603133	T	T	17603133	3	4	41	1	0	0	0	0	1	0	0	0	11433	971	34	4	1473	4	PADI3	1	17603133	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	4767843	17603133	231647488	3	8667											
RAP1GAP	5909	broad.mit.edu	37	chr1	21928278	21928278	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggggtcttctgaccagcCggagggctctccctgcgggg	3	9	16	13	2	4	1	0	1	4	0	5	2	4	2	3	6	2	1	3	6	0	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:21928278C>T	uc001bex.2	-	20	1809	c.1551G>A	c.(1549-1551)CCG>CCA	p.P517P	RAP1GAP_uc001bev.2_Silent_p.P602P|RAP1GAP_uc001bew.2_Silent_p.P581P|RAP1GAP_uc001bey.2_Silent_p.P543P	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	517					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		TCTGACCAGCCGGAGGGCTCT	0.667													26	41					0	0	0	0	T	21928278	T	T	21928278	2	4	41	1	0	0	0	0	0	0	0	1	13102	639	23	1		1	RAP1GAP	1	21928278	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	4325145	21928278	227322343	4	8668											
SFRS4	6429	broad.mit.edu	37	chr1	29475408	29475408	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgccccctttgctcctgctCcggctccgactctggcggag	2	10	11	18	3	1	0	0	0	1	0	4	2	4	1	5	3	3	3	5	3	0	1	rs145832785		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:29475408C>T	uc001bro.2	-	6	1372	c.999G>A	c.(997-999)CGG>CGA	p.R333R	SFRS4_uc010ofy.1_3'UTR	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	333	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		tgctcctgctccggctccgac	0.01													3	41					0	0	0	0	T	29475408	T	T	29475408	2	4	41	1	0	0	0	0	0	0	0	1	14244	842	30	2		2	SFRS4	1	29475408	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	7547130	29475408	219775213	5	8669											
EPS15	2060	broad.mit.edu	37	chr1	51822456	51822456	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatttagtcgggcaagcctCtgctcttcctctctctcact	5	15	7	14	1	4	1	1	1	4	0	8	1	5	1	2	1	2	2	2	1	2	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:51822456C>G	uc001csq.1	-	25	2699	c.2607G>C	c.(2605-2607)CAG>CAC	p.Q869H	EPS15_uc009vyz.1_Missense_Mutation_p.Q735H|EPS15_uc001csp.3_Missense_Mutation_p.Q555H	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	869	UIM 1.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						GGGCAAGCCTCTGCTCTTCCT	0.413			T	MLL	ALL								32	87					0	0	0	0	G	51822456	G	G	51822456	3	3	41	1	0	0	0	0	1	0	0	0	5216	912	32	2	87	2	EPS15	1	51822456	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	22347048	51822456	197428165	6	8670											
ZYG11B	79699	broad.mit.edu	37	chr1	53222179	53222179	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatctgcttgaatttcttgaCtactcaccttgagaagttct	9	17	6	9	0	4	3	1	3	3	1	4	4	4	3	1	0	2	2	1	0	4	7			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:53222179C>T	uc001cuj.2	+	2	275	c.80C>T	c.(79-81)ACT>ATT	p.T27I	ZYG11B_uc009vzg.2_RNA|ZYG11B_uc010onj.1_Missense_Mutation_p.T18I	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	27							protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						AATTTCTTGACTACTCACCTT	0.453													17	152					0	0	0	0	T	53222179	T	T	53222179	3	4	41	1	0	0	0	0	1	0	0	0	18320	565	20	4	86	4	ZYG11B	1	53222179	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	1399723	53222179	196028442	7	8671											
ODF2L	57489	broad.mit.edu	37	chr1	86852648	86852648	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtaaatcttctttctctgaTatagttttaagatggcaaaa	13	16	7	5	0	3	2	0	1	3	1	4	2	3	2	0	2	0	3	0	2	7	7			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:86852648T>C	uc001dll.1	-	2	403	c.63A>G	c.(61-63)ATA>ATG	p.I21M	ODF2L_uc001dlm.1_Missense_Mutation_p.I21M|ODF2L_uc001dln.2_Missense_Mutation_p.I21M|ODF2L_uc001dlo.2_Translation_Start_Site|ODF2L_uc001dlp.2_Missense_Mutation_p.I21M|ODF2L_uc010osg.1_Missense_Mutation_p.I21M|ODF2L_uc001dlq.1_Intron|ODF2L_uc009wcr.1_Intron	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	21						centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		CTTTCTCTGATATAGTTTTAA	0.378													22	131					0	0	0	0	C	86852648	C	C	86852648	3	2	41	1	0	0	0	0	1	0	0	0	10882	1396	49	5	2091	5	ODF2L	1	86852648	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	33630469	86852648	162397973	8	8672											
PIAS3	10401	broad.mit.edu	37	chr1	145581474	145581474	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctgcagagcttcgatgctgCcctttatctacagatgaatg	9	12	9	11	1	1	3	0	1	1	2	2	4	1	3	2	0	5	3	2	0	3	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:145581474C>G	uc001eoc.1	+	9	1146	c.1055C>G	c.(1054-1056)GCC>GGC	p.A352G	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_Missense_Mutation_p.A21G	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	352	SP-RING-type.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCGATGCTGCCCTTTATCTA	0.517													23	141					0	0	0	0	G	145581474	G	G	145581474	3	3	41	1	0	0	0	0	1	0	0	0	11932	739	26	4	1089	4	PIAS3	1	145581474	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	58728826	145581474	103669147	9	8673											
ARNT	405	broad.mit.edu	37	chr1	150784502	150784502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaccccaatagttctattCtgaaaaggggggaaacatag	14	9	9	9	0	3	1	1	1	2	0	3	2	3	2	2	3	1	1	2	3	7	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:150784502C>T	uc001evr.1	-	22	2508	c.2365G>A	c.(2365-2367)GAA>AAA	p.E789K	ARNT_uc010pck.1_Missense_Mutation_p.E277K|ARNT_uc001evs.1_Missense_Mutation_p.E774K|ARNT_uc009wmb.1_Missense_Mutation_p.E775K|ARNT_uc009wmc.1_Missense_Mutation_p.E787K|ARNT_uc009wmd.1_Missense_Mutation_p.E773K	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	789					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TAGTTCTATTCTGAAAAGGGG	0.393			T	ETV6	AML								16	84					0	0	0	0	T	150784502	T	T	150784502	3	4	41	1	0	0	0	0	1	0	0	0	967	922	32	2	8	2	ARNT	1	150784502	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	5203028	150784502	98466119	10	8674											
VANGL2	57216	broad.mit.edu	37	chr1	160394043	160394043	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcatcctgcagcaccttgaAttctgcatcacgcatgacat	11	10	7	13	1	2	2	1	2	1	0	3	2	3	2	2	0	4	5	2	0	1	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:160394043A>T	uc001fwb.1	+	8	1574	c.1275A>T	c.(1273-1275)GAA>GAT	p.E425D	VANGL2_uc001fwc.1_Missense_Mutation_p.E425D	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	425	Cytoplasmic (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGCACCTTGAATTCTGCATCA	0.567													17	42					0	0	0	0	T	160394043	T	T	160394043	3	4	41	1	0	0	0	0	1	0	0	0	17188	98	4	5	1297	5	VANGL2	1	160394043	Missense_Mutation	SNP	A	TCGA-CN-4729-01A-01D-1434-08	9609541	160394043	88856578	11	8675											
FAM5C	339479	broad.mit.edu	37	chr1	190068182	190068182	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggacacgtgcacgagtgcgTctcttctgaaaagctgccta	9	9	11	12	4	2	1	0	1	2	0	3	3	2	2	1	1	4	2	1	1	3	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:190068182T>A	uc001gse.1	-	8	1499	c.1267A>T	c.(1267-1269)ACG>TCG	p.T423S	FAM5C_uc010pot.1_Missense_Mutation_p.T321S	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	423						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CACGAGTGCGTCTCTTCTGAA	0.542													11	34					0	0	0	0	A	190068182	A	A	190068182	3	1	41	1	0	0	0	0	1	0	0	0	5626	1667	58	5	1037	5	FAM5C	1	190068182	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	29674139	190068182	59182439	12	8676											
ASPM	259266	broad.mit.edu	37	chr1	197074167	197074167	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttcttcttaaataagcaCgccaatgcctctgaattgta	11	15	6	9	1	3	1	0	1	3	0	3	1	3	1	2	0	2	3	2	0	6	7	rs143092798		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:197074167C>T	uc001gtu.2	-	18	4471	c.4214G>A	c.(4213-4215)CGT>CAT	p.R1405H	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1405	IQ 2.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TAAATAAGCACGCCAATGCCT	0.313													25	116					0	0	0	0	T	197074167	T	T	197074167	3	4	41	1	0	0	0	0	1	0	0	0	1058	536	19	1	6263	1	ASPM	1	197074167	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	7005985	197074167	52176454	13	8677											
CD34	947	broad.mit.edu	37	chr1	208084367	208084367	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagcaaactcagcaagcaaAgcgcggtccagccccgcggc	11	2	12	16	4	1	0	1	0	0	0	2	0	2	0	3	2	6	4	3	2	3	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:208084367A>G	uc001hgw.1	-	1	317	c.59T>C	c.(58-60)CTT>CCT	p.L20P	CD34_uc001hgx.1_Missense_Mutation_p.L20P|CD34_uc010psj.1_5'UTR	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	20					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						CAGCAAGCAAAGCGCGGTCCA	0.607													4	11					0	0	0	0	G	208084367	G	G	208084367	3	3	41	1	0	0	0	0	1	0	0	0	3021	72	3	5	1149	5	CD34	1	208084367	Missense_Mutation	SNP	A	TCGA-CN-4729-01A-01D-1434-08	11010200	208084367	41166254	14	8678											
TMEM206	55248	broad.mit.edu	37	chr1	212560368	212560368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcaggtagatgaagatgaGtaggaccgagaagacgttct	14	7	14	6	2	1	6	0	2	1	4	1	8	1	7	1	2	1	4	1	2	4	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:212560368G>A	uc001hjc.3	-	3	376	c.208C>T	c.(208-210)CTC>TTC	p.L70F	TMEM206_uc010pte.1_Missense_Mutation_p.L131F	NM_018252	NP_060722	Q9H813	TM206_HUMAN	transmembrane protein 206	70	Helical; (Potential).					integral to membrane				breast(1)	1				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		ATGAAGATGAGTAGGACCGAG	0.542													22	93					0	0	0	0	A	212560368	A	A	212560368	3	1	41	1	0	0	0	0	1	0	0	0	16197	1029	36	4	868	4	TMEM206	1	212560368	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	4476001	212560368	36690253	15	8679											
NLRP3	114548	broad.mit.edu	37	chr1	247608112	247608112	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaacagcagagctgcctcctGcagaacctggggtgagtgtg	10	7	14	10	0	0	3	0	1	0	2	1	3	1	3	3	2	6	3	3	2	2	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:247608112G>C	uc001icr.2	+	10	3138	c.3000G>C	c.(2998-3000)CTG>CTC	p.L1000L	NLRP3_uc001ics.2_Silent_p.L943L|NLRP3_uc001icu.2_Silent_p.L1000L|NLRP3_uc001icw.2_Silent_p.L943L|NLRP3_uc001icv.2_Silent_p.L886L|NLRP3_uc010pyw.1_Silent_p.L978L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	1000					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCTGCCTCCTGCAGAACCTGG	0.562													12	65					0	0	0	0	C	247608112	C	C	247608112	2	2	41	1	0	0	0	0	0	0	0	1	10532	1306	46	4		4	NLRP3	1	247608112	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	35047744	247608112	1642509	16	8680											
OR13G1	441933	broad.mit.edu	37	chr1	247836069	247836069	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagctgggacatgcagcctGcatatgaaatggtattttct	11	12	11	7	0	1	2	0	1	1	1	1	3	1	3	1	2	4	4	1	2	3	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:247836069G>C	uc001idi.1	-	1	275	c.275C>G	c.(274-276)GCA>GGA	p.A92G		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CATGCAGCCTGCATATGAAAT	0.483													6	56					0	0	0	0	C	247836069	C	C	247836069	3	2	41	1	0	0	0	0	1	0	0	0	10996	1319	46	4	652	4	OR13G1	1	247836069	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	227957	247836069	1414552	17	8681											
ZNF672	79894	broad.mit.edu	37	chr1	249142664	249142664	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcgaacggccagcggagtgCgcagagtgcggcaagtgctt	8	5	18	10	5	0	1	0	0	0	1	0	3	0	2	1	4	5	3	1	4	2	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr1:249142664C>T	uc001iex.2	+	4	1886	c.1191C>T	c.(1189-1191)TGC>TGT	p.C397C		NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	397	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CAGCGGAGTGCGCAGAGTGCG	0.677													3	14					0	0	0	0	T	249142664	T	T	249142664	2	4	41	1	0	0	0	0	0	0	0	1	18146	776	27	1		1	ZNF672	1	249142664	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	1306595	249142664	107957	18	8682											
DNMT3A	1788	broad.mit.edu	37	chr2	25468890	25468890	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaggcaacaaacttaccCtcaatgttccggcacttctg	10	10	6	15	1	2	0	1	0	1	0	4	0	4	0	3	2	3	3	3	2	4	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:25468890C>G	uc002rgc.2	-	12	1730	c.1473G>C	c.(1471-1473)GAG>GAC	p.E491D	DNMT3A_uc002rgd.2_Missense_Mutation_p.E491D|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.E302D	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	491	ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAAACTTACCCTCAATGTTCC	0.607			Mis|F|N|S		AML								11	79					0	0	0	0	G	25468890	G	G	25468890	3	3	41	1	0	0	0	0	1	0	0	0	4698	695	24	4	1313	4	DNMT3A	2	25468890	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08		25468890	217730483	19	8683											
FAM179A	165186	broad.mit.edu	37	chr2	29249763	29249763	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacgcggctgagcacctctCagctgtgctggagcagatcg	8	8	13	12	3	1	2	1	1	1	1	3	3	1	3	1	2	5	5	1	2	1	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:29249763C>G	uc010ezl.2	+	14	2249	c.1898C>G	c.(1897-1899)TCA>TGA	p.S633*	FAM179A_uc010ymm.1_Nonsense_Mutation_p.S578*|FAM179A_uc002rmr.3_Nonsense_Mutation_p.S160*	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	633							binding			ovary(3)|skin(1)	4						GAGCACCTCTCAGCTGTGCTG	0.597													4	10					0	0	0	0	G	29249763	G	G	29249763	4	3	41	1	0	0	0	0	0	1	0	0	5533	838	29	2	1948	2	FAM179A	2	29249763	Nonsense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	3780873	29249763	213949610	20	8684											
BIRC6	57448	broad.mit.edu	37	chr2	32664671	32664671	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtaatggtggtatgcgtcctGtagtaaggcttccatcccta	8	13	11	9	1	0	0	0	0	0	0	3	0	3	0	3	3	1	5	3	3	5	6			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:32664671G>T	uc010ezu.2	+	16	3861	c.3727G>T	c.(3727-3729)GTA>TTA	p.V1243L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1243					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TATGCGTCCTGTAGTAAGGCT	0.413													3	65					0.00909568	0.00923144	1	0	T	32664671	T	T	32664671	3	4	41	1	0	0	0	0	1	0	0	0	1441	1377	48	4	3789	4	BIRC6	2	32664671	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	3414908	32664671	210534702	21	8685											
CYP26B1	56603	broad.mit.edu	37	chr2	72361996	72361996	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgcactgcagcttctccCggatggccttctccagcccc	4	10	10	17	1	2	0	0	0	2	0	4	1	2	1	5	2	4	3	5	2	0	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:72361996C>T	uc002sih.1	-	4	755	c.755G>A	c.(754-756)CGG>CAG	p.R252Q	CYP26B1_uc010yra.1_Missense_Mutation_p.R235Q|CYP26B1_uc010yrb.1_Missense_Mutation_p.R177Q	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	252					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2						CAGCTTCTCCCGGATGGCCTT	0.602													18	70					0	0	0	0	T	72361996	T	T	72361996	3	4	41	1	0	0	0	0	1	0	0	0	4173	652	23	1	795	1	CYP26B1	2	72361996	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	39697325	72361996	170837377	22	8686											
GPAT2	150763	broad.mit.edu	37	chr2	96690176	96690176	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgcacctcaagactcaccGcccacagcctcgctcaggaa	10	5	8	18	3	3	1	3	0	0	1	4	2	3	2	4	1	2	2	4	1	2	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:96690176G>A	uc002svf.2	-	15	1891	c.1668C>T	c.(1666-1668)GGC>GGT	p.G556G	GPAT2_uc002svd.2_Silent_p.G375G|GPAT2_uc002sve.2_Silent_p.G358G|GPAT2_uc002svg.2_Silent_p.G435G|GPAT2_uc010yuh.1_Silent_p.G485G|GPAT2_uc002svh.2_Silent_p.G556G	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	556					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						AAGACTCACCGCCCACAGCCT	0.632													9	61					0	0	0	0	A	96690176	A	A	96690176	2	1	41	1	0	0	0	0	0	0	0	1	6627	1101	38	1		1	GPAT2	2	96690176	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	24328180	96690176	146509197	23	8687											
NCK2	8440	broad.mit.edu	37	chr2	106497993	106497993	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgtcatggagaagtgcagcGacggttggtggcggggcagc	7	6	19	9	4	1	1	1	0	0	1	1	3	1	1	1	6	3	3	1	6	1	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:106497993G>A	uc002tdg.2	+	4	878	c.436G>A	c.(436-438)GAC>AAC	p.D146N	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Missense_Mutation_p.D146N	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	146	SH3 2.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GAAGTGCAGCGACGGTTGGTG	0.637													23	40					0	0	0	0	A	106497993	A	A	106497993	3	1	41	1	0	0	0	0	1	0	0	0	10274	1058	37	1	442	1	NCK2	2	106497993	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	9807817	106497993	136701380	24	8688											
GCC2	9648	broad.mit.edu	37	chr2	109085540	109085540	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgaagcaagaggttgaGgtaagtcaatattttagtgt	16	12	11	2	0	1	3	1	2	0	1	1	3	1	3	0	2	1	3	0	2	8	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:109085540G>C	uc002tec.2	+	5	475	c.321G>C	c.(319-321)GAG>GAC	p.E107D	GCC2_uc002ted.2_Missense_Mutation_p.E6D	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	107					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAGAGGTTGAGGTAAGTCAAT	0.303													19	97					0	0	0	0	C	109085540	C	C	109085540	3	2	41	1	0	0	0	0	1	0	0	0	6321	1014	35	4	339	4	GCC2	2	109085540	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	2587547	109085540	134113833	25	8689											
IL1F9	56300	broad.mit.edu	37	chr2	113737637	113737637	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggctcttgagcaaggcaGaggggatcccatttatttgg	10	10	14	7	0	1	3	0	1	1	2	2	4	2	4	1	5	1	3	1	5	2	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:113737637G>C	uc002tio.1	+	4	281	c.212G>C	c.(211-213)AGA>ACA	p.R71T	IL1F9_uc010fkr.1_Missense_Mutation_p.R36T	NM_019618	NP_062564	Q9NZH8	IL36G_HUMAN	interleukin 1 family, member 9	71					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity				0						GAGCAAGGCAGAGGGGATCCC	0.423													13	93					0	0	0	0	C	113737637	C	C	113737637	3	2	41	1	0	0	0	0	1	0	0	0	7696	942	33	2	222	2	IL1F9	2	113737637	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	4652097	113737637	129461736	26	8690											
CNTNAP5	129684	broad.mit.edu	37	chr2	125284919	125284921	+	In_Frame_Del	DEL	GCT	-	-																															tcccattaaggctttccaagGctgcatgaggctcatcttta																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:125284919_125284921delGCT	uc002tno.2	+	10	1896_1898	c.1532_1534delGCT	c.(1531-1536)GGCTGC>GGC	p.C512del	CNTNAP5_uc010flu.2_In_Frame_Del_p.C513del	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	512	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GCTTTCCAAGGCTGCATGAGGCT	0.433													---	---	---								-	125284921	-	-	125284919	7	5	41	1	0	1	0	1	0	0	0	0	3665	1203	42	0	1570	0	CNTNAP5	2	125284919	In_Frame_Del	DEL	GCT	TCGA-CN-4729-01A-01D-1434-08	11547282	125284919	117914454	27	8691											
BIN1	274	broad.mit.edu	37	chr2	127821184	127821184	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagttttcctccaggcccGcgatgctctggaacgtgttg	6	11	13	11	3	1	0	0	0	1	0	3	3	3	2	3	3	2	3	3	3	2	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:127821184G>A	uc002tns.1	-	9	1082	c.737C>T	c.(736-738)GCG>GTG	p.A246V	BIN1_uc010yzf.1_Missense_Mutation_p.A191V|BIN1_uc010yzg.1_Missense_Mutation_p.A246V|BIN1_uc002tnu.1_Missense_Mutation_p.A215V|BIN1_uc002toa.1_Missense_Mutation_p.A215V|BIN1_uc002tnt.1_Missense_Mutation_p.A215V|BIN1_uc002tnv.1_Missense_Mutation_p.A246V|BIN1_uc002tnw.1_Missense_Mutation_p.A215V|BIN1_uc002tnx.1_Missense_Mutation_p.A215V|BIN1_uc002tny.1_Missense_Mutation_p.A246V|BIN1_uc002tnz.1_Missense_Mutation_p.A215V|BIN1_uc002tob.1_Missense_Mutation_p.A215V|BIN1_uc002toc.1_Missense_Mutation_p.A215V	NM_139343	NP_647593	O00499	BIN1_HUMAN	bridging integrator 1 isoform 1	246	BAR.|Potential.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				ovary(2)|central_nervous_system(2)|skin(2)|lung(1)	7	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CTCCAGGCCCGCGATGCTCTG	0.602													9	28					0	0	0	0	A	127821184	A	A	127821184	3	1	41	1	0	0	0	0	1	0	0	0	1435	1087	38	1	1137	1	BIN1	2	127821184	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	2536265	127821184	115378189	28	8692											
AMMECR1L	83607	broad.mit.edu	37	chr2	128631411	128631411	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatttactcactaggggtcaTtggtgaatctaggaagtcgt	10	13	12	6	1	3	1	2	1	1	0	4	3	3	2	0	4	1	0	0	4	5	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:128631411T>C	uc002tpl.2	-	3	649	c.398A>G	c.(397-399)AAT>AGT	p.N133S	AMMECR1L_uc002tpm.2_Missense_Mutation_p.N133S	NM_031445	NP_113633	Q6DCA0	AMERL_HUMAN	AMME chromosomal region gene 1-like	133	AMMECR1.									central_nervous_system(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.07)		CTAGGGGTCATTGGTGAATCT	0.507													21	264					0	0	0	0	C	128631411	C	C	128631411	3	2	41	1	0	0	0	0	1	0	0	0	579	1493	52	5	558	5	AMMECR1L	2	128631411	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	810227	128631411	114567962	29	8693											
LRP1B	53353	broad.mit.edu	37	chr2	141533692	141533692	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgcttctttatcatagacTttcatatgaactaccccaga	11	15	5	10	0	3	3	2	1	1	2	3	3	3	3	2	0	3	1	2	0	5	7			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:141533692T>C	uc002tvj.1	-	33	6447	c.5475A>G	c.(5473-5475)AAA>AAG	p.K1825K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1825	Extracellular (Potential).|LDL-receptor class B 18.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATCATAGACTTTCATATGAA	0.418										TSP Lung(27;0.18)			42	108					0	0	0	0	C	141533692	C	C	141533692	2	2	41	1	0	0	0	0	0	0	0	1	9005	1606	56	5		5	LRP1B	2	141533692	Silent	SNP	T	TCGA-CN-4729-01A-01D-1434-08	12902281	141533692	101665681	30	8694											
SP5	389058	broad.mit.edu	37	chr2	171573747	171573747	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcacgcgctcggacgagctgCagcggcacctgcggactcac	7	5	13	16	6	2	0	2	0	0	0	3	3	2	2	1	3	4	4	1	3	0	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:171573747C>T	uc002uge.2	+	2	1196	c.1030C>T	c.(1030-1032)CAG>TAG	p.Q344*		NM_001003845	NP_001003845	Q6BEB4	SP5_HUMAN	Sp5 transcription factor	344	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGACGAGCTGCAGCGGCACCT	0.667													6	22					0	0	0	0	T	171573747	T	T	171573747	4	4	41	1	0	0	0	0	0	1	0	0	15031	711	25	4	1036	4	SP5	2	171573747	Nonsense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	30040055	171573747	71625626	31	8695											
TTN	7273	broad.mit.edu	37	chr2	179411014	179411014	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaagtgtattttccactgtCacttctgtcacagaacttga	11	15	6	9	0	3	2	2	1	1	1	4	2	4	2	1	0	1	1	1	0	4	6			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:179411014C>G	uc010zfg.1	-	291	87564	c.87340G>C	c.(87340-87342)GAC>CAC	p.D29114H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D22809H|TTN_uc010zfi.1_Missense_Mutation_p.D22742H|TTN_uc010zfj.1_Missense_Mutation_p.D22617H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30041							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCCACTGTCACTTCTGTCA	0.448													62	234					0	0	0	0	G	179411014	G	G	179411014	3	3	41	1	0	0	0	0	1	0	0	0	16803	826	29	2	13019	2	TTN	2	179411014	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	7837267	179411014	63788359	32	8696											
TTN	7273	broad.mit.edu	37	chr2	179442069	179442069	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatggaagatgttggggttGaagttatctgagtgatatct	10	14	14	3	0	2	4	0	3	2	1	2	5	2	5	0	3	0	4	0	3	4	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:179442069G>A	uc010zfg.1	-	273	61513	c.61289C>T	c.(61288-61290)TCA>TTA	p.S20430L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S14125L|TTN_uc010zfi.1_Missense_Mutation_p.S14058L|TTN_uc010zfj.1_Missense_Mutation_p.S13933L|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21357							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTGGGGTTGAAGTTATCTG	0.423													5	76					0	0	0	0	A	179442069	A	A	179442069	3	1	41	1	0	0	0	0	1	0	0	0	16803	1294	45	2	39142	2	TTN	2	179442069	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	31055	179442069	63757304	33	8697											
TTN	7273	broad.mit.edu	37	chr2	179600777	179600778	+	Frame_Shift_Del	DEL	GA	-	-																															ttgtaagggacttaggtctgGagagaaaggttggtggatat																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:179600777_179600778delGA	uc010zfg.1	-	47	10887_10888	c.10663_10664delTC	c.(10663-10665)TCCfs	p.S3555fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.S216fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4482							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTAGGTCTGGAGAGAAAGGTT	0.431													---	---	---								-	179600778	-	-	179600777	7	5	41	1	0	1	0	1	0	0	0	0	16803	1174	41	0	90385	0	TTN	2	179600777	Frame_Shift_Del	DEL	GA	TCGA-CN-4729-01A-01D-1434-08	158708	179600777	63598596	34	8698											
SATB2	23314	broad.mit.edu	37	chr2	200213543	200213544	+	Frame_Shift_Ins	INS	-	T	T																															acggaagagttggttggctcINStggcttaactgctctgggga																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:200213543_200213544insT	uc002uuy.1	-	7	1870_1871	c.1053_1054insA	c.(1051-1056)CCAGAGfs	p.P351fs	SATB2_uc010fsq.1_Frame_Shift_Ins_p.P233fs|SATB2_uc002uuz.1_Frame_Shift_Ins_p.P351fs|SATB2_uc002uva.1_Frame_Shift_Ins_p.P351fs|SATB2_uc002uvb.1_Frame_Shift_Ins_p.P94fs	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	351_352	CUT 1.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTGGTTGGCTCTGGCTTAACTG	0.54													---	---	---								T	200213544	T	T	200213543	7	5	41	1	0	1	1	0	0	0	0	0	13919	922	32	0	1167	0	SATB2	2	200213543	Frame_Shift_Ins	INS	-	TCGA-CN-4729-01A-01D-1434-08	20612766	200213543	42985830	35	8699											
ERBB4	2066	broad.mit.edu	37	chr2	212589879	212589879	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcactgacgtaaggtccgtaGcatctgccgtcacattgttc	8	12	9	12	3	3	1	2	1	1	0	5	1	4	1	2	1	2	4	2	1	2	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:212589879G>A	uc002veg.1	-	6	761	c.663C>T	c.(661-663)TGC>TGT	p.C221C	ERBB4_uc002veh.1_Silent_p.C221C|ERBB4_uc010zji.1_Silent_p.C221C|ERBB4_uc010zjj.1_Silent_p.C221C|ERBB4_uc010fut.1_Silent_p.C221C	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	221	Cys-rich.|Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		AAGGTCCGTAGCATCTGCCGT	0.498										TSP Lung(8;0.080)			30	114					0	0	0	0	A	212589879	A	A	212589879	2	1	41	1	0	0	0	0	0	0	0	1	5233	963	34	4		4	ERBB4	2	212589879	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	12376336	212589879	30609494	36	8700											
FAM124B	79843	broad.mit.edu	37	chr2	225266461	225266461	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aagaagatggacagtcatggCcagaggcccctgtgtctcat	11	8	12	10	0	2	3	2	0	1	3	3	4	2	4	3	3	0	0	3	3	2	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:225266461C>T	uc002vnx.2	-	1	251	c.25G>A	c.(25-27)GCC>ACC	p.A9T	FAM124B_uc002vnw.2_Missense_Mutation_p.A9T	NM_001122779	NP_001116251	Q9H5Z6	F124B_HUMAN	hypothetical protein LOC79843 isoform a	9							protein binding			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		ACAGTCATGGCCAGAGGCCCC	0.542													17	63					0	0	0	0	T	225266461	T	T	225266461	3	4	41	1	0	0	0	0	1	0	0	0	5454	739	26	4	1441	4	FAM124B	2	225266461	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	12676582	225266461	17932912	37	8701											
COL4A3	1285	broad.mit.edu	37	chr2	228153932	228153933	+	Missense_Mutation	DNP	TC	AG	AG																															gatgccaggtttaaagggccTcaaaggactacccggaccag																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:228153932_228153933TC>AG	uc002vom.1	+	35	3110_3111	c.2948_2949TC>AG	c.(2947-2949)CTC>CAG	p.L983Q	COL4A3_uc002von.1_Missense_Mutation_p.L983Q|COL4A3_uc002voo.1_Missense_Mutation_p.L983Q|COL4A3_uc002vop.1_Missense_Mutation_p.L983Q|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	983	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TTAAAGGGCCTCAAAGGACTAC	0.416													3	36					0	0	0	0	AG	228153933	AG	AG	228153932	3	1	41	1	0	0	0	0	1	0	0	0	3706	1551	54	5	3086	5	COL4A3	2	228153932	Missense_Mutation	DNP	TC	TCGA-CN-4729-01A-01D-1434-08	2887471	228153932	15045441	38	8702											
SEPT2	4735	broad.mit.edu	37	chr2	242277151	242277151	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtgaatattgtgcctgtCattgcaaaagctgacactct	12	12	9	8	0	2	2	1	2	1	0	2	2	2	2	1	1	3	2	1	1	5	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr2:242277151C>T	uc002wbc.2	+	8	961	c.540C>T	c.(538-540)GTC>GTT	p.V180V	SEPT2_uc002wbd.2_Silent_p.V180V|SEPT2_uc002wbf.2_Silent_p.V180V|SEPT2_uc002wbg.2_Silent_p.V180V|SEPT2_uc002wbh.2_Silent_p.V190V|SEPT2_uc010zop.1_Silent_p.V215V	NM_001008491	NP_001008491	Q15019	SEPT2_HUMAN	septin 2	180					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(1)	1		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		TTGTGCCTGTCATTGCAAAAG	0.463													25	120					0	0	0	0	T	242277151	T	T	242277151	2	4	41	1	0	0	0	0	0	0	0	1	14129	813	29	2		2	SEPT2	2	242277151	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	14123219	242277151	922222	39	8703											
XIRP1	165904	broad.mit.edu	37	chr3	39227663	39227663	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccccagctttccgaagacCgtcctggatggggttggaag	8	8	14	11	2	0	1	0	0	0	1	2	4	2	3	5	4	2	2	5	4	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:39227663C>A	uc003cjk.1	-	2	3495	c.3274G>T	c.(3274-3276)GGT>TGT	p.G1092C	XIRP1_uc003cji.2_Missense_Mutation_p.G1092C|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1092							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TTCCGAAGACCGTCCTGGATG	0.602													15	86					1.02788e-11	1.13961e-11	1	0	A	39227663	A	A	39227663	3	1	41	1	0	0	0	0	1	0	0	0	17497	652	23	3	2261	3	XIRP1	3	39227663	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08		39227663	158794767	40	8704											
OR5AC2	81050	broad.mit.edu	37	chr3	97806283	97806283	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctggtcaatttcttagaCaagactgcaatgatatccct	12	13	7	9	0	2	3	1	1	1	2	3	3	3	3	1	1	2	2	1	1	5	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:97806283C>T	uc011bgs.1	+	1	267	c.267C>T	c.(265-267)GAC>GAT	p.D89D		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATTTCTTAGACAAGACTGCAA	0.428													58	354					0	0	0	0	T	97806283	T	T	97806283	2	4	41	1	0	0	0	0	0	0	0	1	11195	477	17	4		4	OR5AC2	3	97806283	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	58578620	97806283	100216147	41	8705											
ITGB5	3693	broad.mit.edu	37	chr3	124515329	124515329	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aactcgctctcgaagcaggaGcactggttgcagctgcagtc	9	8	12	12	2	1	0	0	0	1	0	4	2	1	1	0	2	6	7	0	2	2	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:124515329G>A	uc003eho.2	-	10	1896	c.1599C>T	c.(1597-1599)TGC>TGT	p.C533C	ITGB5_uc010hrx.2_RNA	NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	533	Extracellular (Potential).|II.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)		CGAAGCAGGAGCACTGGTTGC	0.597													36	133					0	0	0	0	A	124515329	A	A	124515329	2	1	41	1	0	0	0	0	0	0	0	1	7937	963	34	4		4	ITGB5	3	124515329	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	26709046	124515329	73507101	42	8706											
C3orf37	56941	broad.mit.edu	37	chr3	129020915	129020915	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcaccttccatgcagtctCttctgtggtgaacaactcgc	8	12	7	14	1	3	1	1	1	2	0	6	1	4	1	2	1	3	1	2	1	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:129020915C>G	uc003elt.2	+	6	846	c.758C>G	c.(757-759)TCT>TGT	p.S253C	C3orf37_uc003elu.2_Missense_Mutation_p.S211C|C3orf37_uc003elv.2_Missense_Mutation_p.S253C|C3orf37_uc003elw.2_Missense_Mutation_p.S253C	NM_020187	NP_064572	Q96FZ2	CC037_HUMAN	hypothetical protein LOC56941	253										ovary(1)	1						CATGCAGTCTCTTCTGTGGTG	0.483													15	205					0	0	0	0	G	129020915	G	G	129020915	3	3	41	1	0	0	0	0	1	0	0	0	2237	913	32	2	776	2	C3orf37	3	129020915	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	4505586	129020915	69001515	43	8707											
TRIM42	287015	broad.mit.edu	37	chr3	140406816	140406816	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtctgatcgcctactccaAggaagccctgaaggagactg	10	8	12	11	1	1	3	0	2	1	1	3	5	2	4	3	3	2	0	3	3	4	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:140406816A>T	uc003eto.1	+	3	1483	c.1292A>T	c.(1291-1293)AAG>ATG	p.K431M		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	431						intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						GCCTACTCCAAGGAAGCCCTG	0.502													7	75					0	0	0	0	T	140406816	T	T	140406816	3	4	41	1	0	0	0	0	1	0	0	0	16584	72	3	5	1302	5	TRIM42	3	140406816	Missense_Mutation	SNP	A	TCGA-CN-4729-01A-01D-1434-08	11385901	140406816	57615614	44	8708											
ZIC4	84107	broad.mit.edu	37	chr3	147108849	147108849	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagccagagctgggcggcggCgagcgcccgtgcaccttcat	6	6	15	14	5	1	1	1	0	0	1	1	2	1	1	3	3	4	2	3	3	1	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:147108849C>T	uc003ewd.1	-	4	1146	c.873G>A	c.(871-873)TCG>TCA	p.S291S	ZIC4_uc003ewc.1_Silent_p.S221S|ZIC4_uc011bno.1_Silent_p.S341S	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	291						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						TGGGCGGCGGCGAGCGCCCGT	0.672													14	55					0	0	0	0	T	147108849	T	T	147108849	2	4	41	1	0	0	0	0	0	0	0	1	17748	755	27	1		1	ZIC4	3	147108849	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	6702033	147108849	50913581	45	8709											
MED12L	116931	broad.mit.edu	37	chr3	151105633	151105633	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgaagcagaaggtgtccccGtgggacttgtttgagggtca	9	9	15	8	2	1	2	1	1	0	1	2	4	2	3	2	3	1	2	2	3	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:151105633G>A	uc003eyp.2	+	35	5057	c.5019G>A	c.(5017-5019)CCG>CCA	p.P1673P	MED12L_uc011bnz.1_Silent_p.P1533P|MED12L_uc003eyy.1_Silent_p.P836P	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1673					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGGTGTCCCCGTGGGACTTGT	0.532													15	119					0	0	0	0	A	151105633	A	A	151105633	2	1	41	1	0	0	0	0	0	0	0	1	9482	1132	40	1		1	MED12L	3	151105633	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	3996784	151105633	46916797	46	8710											
PSMD2	5708	broad.mit.edu	37	chr3	184018206	184018206	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaaactgaaggaaatctatGagaacatggcccctggggag	14	6	13	8	0	1	2	0	2	1	1	1	5	1	4	2	4	2	1	2	4	5	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:184018206G>C	uc003fnn.1	+	3	364	c.331G>C	c.(331-333)GAG>CAG	p.E111Q	PSMD2_uc011brj.1_5'Flank|PSMD2_uc011brk.1_5'Flank	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	111					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	GGAAATCTATGAGAACATGGC	0.458													12	117					0	0	0	0	C	184018206	C	C	184018206	3	2	41	1	0	0	0	0	1	0	0	0	12760	1291	45	2	341	2	PSMD2	3	184018206	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	32912573	184018206	14004224	47	8711											
IL1RAP	3556	broad.mit.edu	37	chr3	190362143	190362143	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtttactggctagagatggtCctattttaccgggctcattt	7	16	10	8	1	1	1	1	0	0	1	2	2	2	1	2	3	2	3	2	3	4	7			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:190362143C>T	uc003fsm.1	+	10	1364	c.1158C>T	c.(1156-1158)GTC>GTT	p.V386V	IL1RAP_uc010hzg.1_Silent_p.V386V|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Silent_p.V386V|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Silent_p.V386V	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	386	Helical; (Potential).				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		TAGAGATGGTCCTATTTTACC	0.398													17	87					0	0	0	0	T	190362143	T	T	190362143	2	4	41	1	0	0	0	0	0	0	0	1	7699	842	30	2		2	IL1RAP	3	190362143	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	6343937	190362143	7660287	48	8712											
RNF168	165918	broad.mit.edu	37	chr3	196198801	196198801	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctctagtagaatttggcatCtttcttctattaactgactg	9	18	6	8	0	4	2	0	1	4	1	5	2	4	2	0	1	1	2	0	1	5	7			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr3:196198801C>T	uc003fwq.2	-	6	2143	c.1605G>A	c.(1603-1605)AAG>AAA	p.K535K	RNF168_uc010iah.2_Silent_p.K368K|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	535					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		AATTTGGCATCTTTCTTCTAT	0.398													11	450					0	0	0	0	T	196198801	T	T	196198801	2	4	41	1	0	0	0	0	0	0	0	1	13524	912	32	2		2	RNF168	3	196198801	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	5836658	196198801	1823629	49	8713											
RBPJ	3516	broad.mit.edu	37	chr4	26422343	26422343	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcagtcattgaaaaatgcTgactgtatgtatgcttttct	12	15	8	6	0	2	2	1	2	1	0	2	2	2	2	0	0	3	5	0	0	5	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:26422343T>C	uc003grx.1	+	6	767	c.531T>C	c.(529-531)GCT>GCC	p.A177A	RBPJ_uc003gry.1_Silent_p.A162A|RBPJ_uc003grz.1_Silent_p.A177A|RBPJ_uc011bxt.1_Silent_p.A177A|RBPJ_uc003gsa.1_Silent_p.A163A|RBPJ_uc003gsb.1_Silent_p.A164A|RBPJ_uc003gsc.1_Silent_p.A163A	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	177					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				TGAAAAATGCTGACTGTATGT	0.353													43	31					0	0	0	0	C	26422343	C	C	26422343	2	2	41	1	0	0	0	0	0	0	0	1	13226	1567	55	5		5	RBPJ	4	26422343	Silent	SNP	T	TCGA-CN-4729-01A-01D-1434-08		26422343	164731933	50	8714											
N4BP2	55728	broad.mit.edu	37	chr4	40123657	40123657	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatttattttactgattctcTtgaaataaagagaaatgaaa	18	15	5	3	0	1	4	0	3	1	1	2	5	1	4	0	0	1	0	0	0	8	7			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:40123657T>C	uc003guy.3	+	9	4264	c.3926T>C	c.(3925-3927)CTT>CCT	p.L1309P	N4BP2_uc010ifq.2_Missense_Mutation_p.L1229P|N4BP2_uc010ifr.2_Missense_Mutation_p.L1229P	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1309						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						ACTGATTCTCTTGAAATAAAG	0.259													3	34					0	0	0	0	C	40123657	C	C	40123657	3	2	41	1	0	0	0	0	1	0	0	0	10163	1609	56	5	3952	5	N4BP2	4	40123657	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	13701314	40123657	151030619	51	8715											
KIAA1211	57482	broad.mit.edu	37	chr4	57182127	57182127	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacagagttcacgacctcgtCggacagcgagactgcaaacg	12	5	11	13	5	1	2	1	0	0	2	3	5	1	3	1	1	3	2	1	1	1	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:57182127C>T	uc003hbk.2	+	8	2850	c.2459C>T	c.(2458-2460)TCG>TTG	p.S820L	KIAA1211_uc010iha.2_Missense_Mutation_p.S813L|KIAA1211_uc011bzz.1_Missense_Mutation_p.S730L|KIAA1211_uc003hbm.1_Missense_Mutation_p.S706L	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	820										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					ACGACCTCGTCGGACAGCGAG	0.532													20	98					0	0	0	0	T	57182127	T	T	57182127	3	4	41	1	0	0	0	0	1	0	0	0	8254	893	31	1	2477	1	KIAA1211	4	57182127	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	17058470	57182127	133972149	52	8716											
ANKRD17	26057	broad.mit.edu	37	chr4	73963824	73963824	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccagaaacagattttctctCttcctttggaaatgtaacaa	13	13	6	9	0	2	2	0	0	2	2	4	3	3	3	2	1	2	1	2	1	4	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:73963824C>G	uc003hgp.2	-	26	5104	c.4987G>C	c.(4987-4989)GAG>CAG	p.E1663Q	ANKRD17_uc003hgo.2_Missense_Mutation_p.E1550Q|ANKRD17_uc003hgq.2_Missense_Mutation_p.E1412Q|ANKRD17_uc003hgr.2_Missense_Mutation_p.E1662Q	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1663	Ser-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GATTTTCTCTCTTCCTTTGGA	0.363													16	182					0	0	0	0	G	73963824	G	G	73963824	3	3	41	1	0	0	0	0	1	0	0	0	646	922	32	2	2860	2	ANKRD17	4	73963824	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	16781697	73963824	117190452	53	8717											
NHEDC2	133308	broad.mit.edu	37	chr4	103949913	103949913	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atccatcatacctgaactgtGgcctttggaagccatgcaaa	12	10	8	11	0	1	1	1	1	0	0	2	2	2	2	4	2	4	1	4	2	4	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:103949913G>A	uc003hwx.3	-	11	2255	c.1383C>T	c.(1381-1383)GCC>GCT	p.A461A	NHEDC2_uc010iln.1_Intron|NHEDC2_uc003hwy.2_Silent_p.A461A|NHEDC2_uc011cew.1_Silent_p.A404A|NHEDC2_uc011cex.1_Intron	NM_178833	NP_849155	Q86UD5	NHDC2_HUMAN	Na+/H+ exchanger domain containing 2	461					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity				0				OV - Ovarian serous cystadenocarcinoma(123;2.3e-08)		CCTGAACTGTGGCCTTTGGAA	0.338													10	66					0	0	0	0	A	103949913	A	A	103949913	2	1	41	1	0	0	0	0	0	0	0	1	10455	1335	47	4		4	NHEDC2	4	103949913	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	29986089	103949913	87204363	54	8718											
NHEDC2	133308	broad.mit.edu	37	chr4	103949935	103949935	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttggaagccatgcaaaaGaaataaatatcttttctttt	14	15	5	7	0	2	1	0	0	2	1	2	2	2	2	2	1	2	1	2	1	7	7			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:103949935G>C	uc003hwx.3	-	11	2233	c.1361C>G	c.(1360-1362)TCT>TGT	p.S454C	NHEDC2_uc010iln.1_Intron|NHEDC2_uc003hwy.2_Missense_Mutation_p.S454C|NHEDC2_uc011cew.1_Missense_Mutation_p.S397C|NHEDC2_uc011cex.1_Intron	NM_178833	NP_849155	Q86UD5	NHDC2_HUMAN	Na+/H+ exchanger domain containing 2	454					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity				0				OV - Ovarian serous cystadenocarcinoma(123;2.3e-08)		CCATGCAAAAGAAATAAATAT	0.363													9	75					0	0	0	0	C	103949935	C	C	103949935	3	2	41	1	0	0	0	0	1	0	0	0	10455	942	33	2	260	2	NHEDC2	4	103949935	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	22	103949935	87204341	55	8719											
FAT4	79633	broad.mit.edu	37	chr4	126336921	126336921	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctccatattctgtaaatgTccctgagaatttagggacac	12	13	7	9	0	2	1	0	1	2	1	4	3	3	2	2	1	0	1	2	1	5	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:126336921T>C	uc003ifj.3	+	5	6803	c.6803T>C	c.(6802-6804)GTC>GCC	p.V2268A	FAT4_uc011cgp.1_Missense_Mutation_p.V566A	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2268	Extracellular (Potential).|Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCTGTAAATGTCCCTGAGAAT	0.368													10	81					0	0	0	0	C	126336921	C	C	126336921	3	2	41	1	0	0	0	0	1	0	0	0	5724	1667	58	5	6821	5	FAT4	4	126336921	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	22386986	126336921	64817355	56	8720											
GRIA2	2891	broad.mit.edu	37	chr4	158284089	158284089	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggcgaaacgaatgaaggtgGcaaagaatgcacagaatatt	18	6	12	5	2	0	3	0	1	0	2	0	5	0	3	0	3	2	2	0	3	7	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr4:158284089G>T	uc003ipm.3	+	15	3004	c.2545G>T	c.(2545-2547)GCA>TCA	p.A849S	GRIA2_uc011cit.1_Missense_Mutation_p.A802S|GRIA2_uc003ipl.3_Missense_Mutation_p.A849S|GRIA2_uc003ipk.3_Missense_Mutation_p.A802S|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_3'UTR|GRIA2_uc011ciy.1_3'UTR|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	849	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AATGAAGGTGGCAAAGAATGC	0.433													24	102					2.89027e-11	3.13625e-11	1	0	T	158284089	T	T	158284089	3	4	41	1	0	0	0	0	1	0	0	0	6807	1203	42	4	2722	4	GRIA2	4	158284089	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	31947168	158284089	32870187	57	8721											
SEMA5A	9037	broad.mit.edu	37	chr5	9108255	9108255	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagaaggctactcaccacAttgcagcctgcacagtcagg	13	6	10	12	0	2	2	2	0	0	2	2	2	2	2	2	2	4	3	2	2	3	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:9108255A>G	uc003jek.2	-	16	2782	c.2070T>C	c.(2068-2070)AAT>AAC	p.N690N		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	690	TSP type-1 3.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TACTCACCACATTGCAGCCTG	0.542													13	52					0	0	0	0	G	9108255	G	G	9108255	2	3	41	1	0	0	0	0	0	0	0	1	14102	214	8	5		5	SEMA5A	5	9108255	Silent	SNP	A	TCGA-CN-4729-01A-01D-1434-08		9108255	171807005	58	8722											
MARCH6	10299	broad.mit.edu	37	chr5	10414543	10414543	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccttatgttttactttgcAgatatttctgttgattgtct	6	22	6	7	0	2	2	0	1	2	1	3	2	3	2	1	0	2	3	1	0	3	8			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:10414543A>T	uc003jet.1	+	20	2080	c.1897_splice	c.e20-2	p.I633_splice	MARCH6_uc011cmu.1_Splice_Site_p.I585_splice|MARCH6_uc003jeu.1_Splice_Site_p.I331_splice|MARCH6_uc011cmv.1_Splice_Site_p.I528_splice	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6						protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						TTTACTTTGCAGATATTTCTG	0.348													64	112					0	0	0	0	T	10414543	T	T	10414543	5	4	41	1	0	0	0	0	0	0	1	0	9358	202	7	5	1973	5	MARCH6	5	10414543	Splice_Site	SNP	A	TCGA-CN-4729-01A-01D-1434-08	1306288	10414543	170500717	59	8723											
CDH10	1008	broad.mit.edu	37	chr5	24593422	24593422	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttcaagtaagaaaaattGattccacatccaaccacgtt	15	12	4	10	1	2	2	1	1	1	1	4	2	4	2	3	0	1	2	3	0	5	6			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:24593422G>C	uc003jgr.1	-	2	510	c.178C>G	c.(178-180)CAA>GAA	p.Q60E	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	60	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AAGAAAAATTGATTCCACATC	0.383										HNSCC(23;0.051)			6	236					0	0	0	0	C	24593422	C	C	24593422	3	2	41	1	0	0	0	0	1	0	0	0	3111	1299	45	2	2232	2	CDH10	5	24593422	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	14178879	24593422	156321838	60	8724											
ITGA2	3673	broad.mit.edu	37	chr5	52347333	52347333	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgattgtagcaacatcccaGacatcccaatatggtgggga	13	9	10	9	0	0	2	0	1	0	1	2	3	2	3	2	3	2	2	2	3	4	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:52347333G>A	uc003joy.2	+	7	866	c.723G>A	c.(721-723)CAG>CAA	p.Q241Q	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Silent_p.Q165Q|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	241	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CAACATCCCAGACATCCCAAT	0.373													43	80					0	0	0	0	A	52347333	A	A	52347333	2	1	41	1	0	0	0	0	0	0	0	1	7914	933	33	2		2	ITGA2	5	52347333	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	27753911	52347333	128567927	61	8725											
PIK3R1	5295	broad.mit.edu	37	chr5	67591278	67591279	+	Nonsense_Mutation	DNP	GA	CT	CT																															caaaaaggtgttcggcaaaaGaagttgaacgagtggttggg																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:67591278_67591279GA>CT	uc003jva.2	+	14	2336_2337	c.1776_1777GA>CT	c.(1774-1779)AAGAAG>AACTAG	p.592_593KK>N*	PIK3R1_uc003jvb.2_Nonsense_Mutation_p.592_593KK>N*|PIK3R1_uc003jvc.2_Nonsense_Mutation_p.292_293KK>N*|PIK3R1_uc003jvd.2_Nonsense_Mutation_p.322_323KK>N*|PIK3R1_uc003jve.2_Nonsense_Mutation_p.271_272KK>N*|PIK3R1_uc011crb.1_Nonsense_Mutation_p.262_263KK>N*	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	592_593					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.M582_D605>I(4)|p.Y580fs*1(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TTCGGCAAAAGAAGTTGAACGA	0.361			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			5	73					0	0	0	0	CT	67591279	CT	CT	67591278	4	2	41	1	0	0	0	0	0	1	0	0	11973	933	33	2	1956	2	PIK3R1	5	67591278	Nonsense_Mutation	DNP	GA	TCGA-CN-4729-01A-01D-1434-08	15243945	67591278	113323982	62	8726											
PCDHAC1	56135	broad.mit.edu	37	chr5	140308890	140308890	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcggaataggaaaggggatCacgctaatgtcaatgccatg	13	9	12	7	2	2	0	2	0	0	0	3	3	2	3	1	4	1	1	1	4	5	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:140308890C>A	uc003lih.2	+	1	2589	c.2413C>A	c.(2413-2415)CAC>AAC	p.H805N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.H805N	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	805	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAGGGGATCACGCTAATGT	0.453													22	162					2.44723e-14	2.77353e-14	1	0	A	140308890	A	A	140308890	3	1	41	1	0	0	0	0	1	0	0	0	11586	826	29	2	2415	2	PCDHAC1	5	140308890	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	72717612	140308890	40606370	63	8727											
GABRB2	2561	broad.mit.edu	37	chr5	160973412	160973412	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgacatattactagggtCattgacactaaagaaagaaa	18	8	8	7	1	1	3	1	1	0	2	1	4	1	3	0	1	2	0	0	1	7	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:160973412C>A	uc003lys.1	-	3	303	c.85G>T	c.(85-87)GAC>TAC	p.D29Y	GABRB2_uc011deh.1_Intron|GABRB2_uc003lyr.1_Missense_Mutation_p.D29Y|GABRB2_uc003lyt.1_Missense_Mutation_p.D29Y|GABRB2_uc010jiu.1_Intron|GABRB2_uc011dei.1_Missense_Mutation_p.D29Y	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	29	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTACTAGGGTCATTGACACTA	0.443													14	48					2.32078e-09	2.49179e-09	1	0	A	160973412	A	A	160973412	3	1	41	1	0	0	0	0	1	0	0	0	6201	826	29	2	1489	2	GABRB2	5	160973412	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	20664522	160973412	19941848	64	8728											
CCDC99	54908	broad.mit.edu	37	chr5	169031117	169031117	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaagaaggaaaagaaacttCaagcaaattggaaaaagaaa	25	5	8	3	0	1	3	1	0	0	3	1	5	1	5	0	2	2	1	0	2	11	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr5:169031117C>G	uc003mae.3	+	12	2003	c.1724C>G	c.(1723-1725)TCA>TGA	p.S575*	CCDC99_uc011deq.1_Nonsense_Mutation_p.S392*|CCDC99_uc010jjk.2_Nonsense_Mutation_p.S301*	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	575					cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAAGAAACTTCAAGCAAATTG	0.363													32	81					0	0	0	0	G	169031117	G	G	169031117	4	3	41	1	0	0	0	0	0	1	0	0	2889	838	29	2	1766	2	CCDC99	5	169031117	Nonsense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	8057705	169031117	11884143	65	8729											
KDM1B	221656	broad.mit.edu	37	chr6	18207751	18207751	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagggcttgacattcaactCaaatctccagtgagtatcaa	14	10	8	9	0	4	2	3	2	1	0	5	3	4	2	1	1	1	2	1	1	5	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:18207751C>T	uc003nco.1	+	9	1248	c.1173C>T	c.(1171-1173)CTC>CTT	p.L391L	KDM1B_uc003ncn.1_Silent_p.L362L	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	594					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						ACATTCAACTCAAATCTCCAG	0.517													29	70					0	0	0	0	T	18207751	T	T	18207751	2	4	41	1	0	0	0	0	0	0	0	1	8162	813	29	2		2	KDM1B	6	18207751	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08		18207751	152907316	66	8730											
SKIV2L	6499	broad.mit.edu	37	chr6	31931233	31931233	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgattagcactgtaaccCgccccgtgcccctggagcac	8	8	10	15	2	0	1	0	1	0	0	0	2	0	2	5	1	4	3	5	1	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:31931233C>T	uc003nyn.1	+	14	1836	c.1447C>T	c.(1447-1449)CGC>TGC	p.R483C	SKIV2L_uc011dou.1_Missense_Mutation_p.R325C|SKIV2L_uc011dov.1_Missense_Mutation_p.R290C	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	483						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CACTGTAACCCGCCCCGTGCC	0.562													21	89					0	0	0	0	T	31931233	T	T	31931233	3	4	41	1	0	0	0	0	1	0	0	0	14424	652	23	1	1501	1	SKIV2L	6	31931233	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	13723482	31931233	139183834	67	8731											
B3GALT4	8705	broad.mit.edu	37	chr6	33245570	33245570	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccccgtgtggggttcccaggGgagtgacctggcctcggagt	4	8	17	12	2	0	1	0	1	0	0	2	3	1	3	5	6	0	1	5	6	0	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:33245570G>T	uc003odr.2	+	1	654	c.374G>T	c.(373-375)GGG>GTG	p.G125V		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	125	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						GGTTCCCAGGGGAGTGACCTG	0.672													44	207					5.20006e-24	6.02734e-24	1	0	T	33245570	T	T	33245570	3	4	41	1	0	0	0	0	1	0	0	0	1251	1232	43	4	376	4	B3GALT4	6	33245570	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	1314337	33245570	137869497	68	8732											
CUL9	23113	broad.mit.edu	37	chr6	43155036	43155037	+	Missense_Mutation	DNP	CC	TT	TT																															gggctgtaccctttgccgtaCctccagcccgaacctcagaa																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:43155036_43155037CC>TT	uc003ouk.2	+	6	1515_1516	c.1440_1441CC>TT	c.(1438-1443)TACCTC>TATTTC	p.L481F	CUL9_uc003ouj.1_Intron|CUL9_uc003oul.2_Missense_Mutation_p.L481F|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_Intron	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	481					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CTTTGCCGTACCTCCAGCCCGA	0.54													43	219					0	0	0	0	TT	43155037	TT	TT	43155036	3	4	41	1	0	0	0	0	1	0	0	0	4078	518	18	4	1458	4	CUL9	6	43155036	Missense_Mutation	DNP	CC	TCGA-CN-4729-01A-01D-1434-08	9909466	43155036	127960031	69	8733											
SENP6	26054	broad.mit.edu	37	chr6	76412714	76412714	+	Frame_Shift_Del	DEL	C	-	-																															caataaaggagaatctacatCccagaaagttgctgatagga																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:76412714delC	uc003pid.3	+	19	3261	c.2642delC	c.(2641-2643)TCCfs	p.S881fs	SENP6_uc003pie.3_Frame_Shift_Del_p.S874fs|SENP6_uc010kbf.2_Intron	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	881	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				GAATCTACATCCCAGAAAGTT	0.328													---	---	---								-	76412714	-	-	76412714	7	5	41	1	0	1	0	1	0	0	0	0	14115	855	30	0	2716	0	SENP6	6	76412714	Frame_Shift_Del	DEL	C	TCGA-CN-4729-01A-01D-1434-08	33257678	76412714	94702353	70	8734											
CASP8AP2	9994	broad.mit.edu	37	chr6	90572083	90572083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacatttacctacatctgttGagaaacactgcactaatggt	13	12	6	10	0	1	1	0	1	1	1	1	2	1	1	1	1	4	2	1	1	4	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:90572083G>A	uc003pnr.2	+	7	851	c.655G>A	c.(655-657)GAG>AAG	p.E219K	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E219K|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E219K	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	219					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TACATCTGTTGAGAAACACTG	0.388													31	231					0	0	0	0	A	90572083	A	A	90572083	3	1	41	1	0	0	0	0	1	0	0	0	2690	1291	45	2	677	2	CASP8AP2	6	90572083	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	14159369	90572083	80542984	71	8735											
GJA10	84694	broad.mit.edu	37	chr6	90605064	90605064	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acaatcaacagcaagtcattCgagttaatgtgccaaagtct	15	10	7	9	1	3	0	2	0	1	0	4	1	3	0	1	0	3	2	1	0	5	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr6:90605064C>G	uc011eaa.1	+	1	877	c.877C>G	c.(877-879)CGA>GGA	p.R293G		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	293	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		GCAAGTCATTCGAGTTAATGT	0.433													10	77					0	0	0	0	G	90605064	G	G	90605064	3	3	41	1	0	0	0	0	1	0	0	0	6438	876	31	3	879	3	GJA10	6	90605064	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	32981	90605064	80510003	72	8736											
EIF3B	8662	broad.mit.edu	37	chr7	2415133	2415133	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctactgggcgctacgtcGtcacctctgtgtcctggtgg	4	12	12	13	3	2	0	1	0	1	0	5	0	4	0	3	3	2	1	3	3	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:2415133G>A	uc003slx.2	+	14	2082	c.1999G>A	c.(1999-2001)GTC>ATC	p.V667I	EIF3B_uc003sly.2_Missense_Mutation_p.V667I|EIF3B_uc003sma.2_Missense_Mutation_p.V395I|EIF3B_uc003smb.2_5'Flank	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	667	WD 5.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		GCGCTACGTCGTCACCTCTGT	0.562													24	84					0	0	0	0	A	2415133	A	A	2415133	3	1	41	1	0	0	0	0	1	0	0	0	5035	1145	40	1	2053	1	EIF3B	7	2415133	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08		2415133	156723530	73	8737											
GHRHR	2692	broad.mit.edu	37	chr7	31008504	31008504	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccagctgagagaggatgAgagtgcctgtctacaagcag	12	6	13	10	0	1	3	0	2	1	2	1	6	1	4	2	1	4	2	2	1	2	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:31008504A>G	uc003tbx.2	+	2	161	c.113A>G	c.(112-114)GAG>GGG	p.E38G	GHRHR_uc003tbw.1_Missense_Mutation_p.E38G|GHRHR_uc003tby.2_5'Flank|GHRHR_uc003tbz.2_5'Flank	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	38	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	AGAGAGGATGAGAGTGCCTGT	0.537													11	51					0	0	0	0	G	31008504	G	G	31008504	3	3	41	1	0	0	0	0	1	0	0	0	6410	304	11	5	119	5	GHRHR	7	31008504	Missense_Mutation	SNP	A	TCGA-CN-4729-01A-01D-1434-08	28593371	31008504	128130159	74	8738											
MAGI2	9863	broad.mit.edu	37	chr7	78130931	78130931	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcccttctctgtataggccaTttcccagttatcaggcaatg	8	13	8	12	0	2	0	1	0	1	0	4	0	3	0	3	2	0	3	3	2	4	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:78130931T>A	uc003ugx.2	-	5	1182	c.928A>T	c.(928-930)ATG>TTG	p.M310L	MAGI2_uc003ugy.2_Missense_Mutation_p.M310L|MAGI2_uc011kgr.1_Missense_Mutation_p.M142L|MAGI2_uc011kgs.1_Missense_Mutation_p.M147L	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	310	WW 1.|Interaction with DDN.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GTATAGGCCATTTCCCAGTTA	0.448													23	179					0	0	0	0	A	78130931	A	A	78130931	3	1	41	1	0	0	0	0	1	0	0	0	9244	1493	52	5	3511	5	MAGI2	7	78130931	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	47122427	78130931	81007732	75	8739											
SAMD9	54809	broad.mit.edu	37	chr7	92733477	92733477	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcagtcatgatatcttctTcctttttcagaaggacagtc	10	14	8	9	0	4	2	2	1	2	1	6	4	5	3	1	1	1	1	1	1	2	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:92733477T>A	uc003umf.2	-	3	2190	c.1934A>T	c.(1933-1935)GAA>GTA	p.E645V	SAMD9_uc003umg.2_Missense_Mutation_p.E645V	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	645						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GATATCTTCTTCCTTTTTCAG	0.353													23	192					0	0	0	0	A	92733477	A	A	92733477	3	1	41	1	0	0	0	0	1	0	0	0	13891	1783	62	5	2839	5	SAMD9	7	92733477	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	14602546	92733477	66405186	76	8740											
NPTX2	4885	broad.mit.edu	37	chr7	98248963	98248963	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtggctgaaagcaccagctCagagcaaacgtgtccaatgc	12	6	12	11	1	1	2	1	1	0	1	2	2	2	2	2	2	5	4	2	2	3	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:98248963C>G	uc003upl.2	+	2	612	c.435C>G	c.(433-435)CTC>CTG	p.L145L		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	145					synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			AGCACCAGCTCAGAGCAAACG	0.607													57	135					0	0	0	0	G	98248963	G	G	98248963	2	3	41	1	0	0	0	0	0	0	0	1	10657	813	29	2		2	NPTX2	7	98248963	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	5515486	98248963	60889700	77	8741											
TNPO3	23534	broad.mit.edu	37	chr7	128696595	128696595	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgtgtgggccactggtactgGcaagactgcaacaccccaac	10	6	11	14	1	0	1	0	0	0	1	0	1	0	1	3	3	4	3	3	3	4	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:128696595G>A	uc003vol.1	-						TNPO3_uc003vom.1_5'Flank|TNPO3_uc010lly.1_5'Flank|TNPO3_uc010llz.1_5'Flank|TPI1P2_uc003von.1_RNA	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3						splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						ACTGGTACTGGCAAGACTGCA	0.522													4	84					0	0	0	0	A	128696595	A	A	128696595	1	1	41	0	1	0	0	0	0	0	0	0	16403	1218	42	4		4	TNPO3	7	128696595	5'Flank	SNP	G	TCGA-CN-4729-01A-01D-1434-08	30447632	128696595	30442068	78	8742											
OR2A7	401427	broad.mit.edu	37	chr7	143956646	143956646	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagggagaagagcccaaagaGgagcatctgaatccttgggc	13	5	14	9	0	1	4	0	1	1	3	2	6	2	5	2	3	2	1	2	3	3	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:143956646G>A	uc011kuc.1	-	1	76	c.76C>T	c.(76-78)CTC>TTC	p.L26F	OR2A9P_uc003wec.1_Intron|OR2A7_uc003wef.2_3'UTR	NM_001005328	NP_001005328	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.14)					AGCCCAAAGAGGAGCATCTGA	0.527													10	73					0	0	0	0	A	143956646	A	A	143956646	3	1	41	1	0	0	0	0	1	0	0	0	11036	1000	35	4	859	4	OR2A7	7	143956646	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	15260051	143956646	15182017	79	8743											
ABP1	26	broad.mit.edu	37	chr7	150553769	150553780	+	In_Frame_Del	DEL	CTCATCGAGATG	-	-																															tggccaagaacaccgtgtttCtcatcgagatgctgctgccc																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr7:150553769_150553780delCTCATCGAGATG	uc003why.1	+	3	4429_4440	c.211_222delCTCATCGAGATG	c.(211-222)CTCATCGAGATGdel	p.LIEM71del	ABP1_uc003whz.1_In_Frame_Del_p.LIEM71del|ABP1_uc003wia.1_In_Frame_Del_p.LIEM71del	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	71_74					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	CACCGTGTTTCTCATCGAGATGCTGCTGCCCA	0.557													---	---	---								-	150553780	-	-	150553769	7	5	41	1	0	1	0	1	0	0	0	0	98	913	32	0	213	0	ABP1	7	150553769	In_Frame_Del	DEL	CTCATCGAGATG	TCGA-CN-4729-01A-01D-1434-08	6597123	150553769	8584894	80	8744											
EFHA2	286097	broad.mit.edu	37	chr8	16956031	16956031	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatacactgagacgtaacaCaagccaagcactgttttcag	14	8	9	10	1	1	1	1	1	0	1	1	3	1	2	1	1	4	3	1	1	4	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:16956031C>T	uc003wxd.2	+	9	995	c.953C>T	c.(952-954)ACA>ATA	p.T318I		NM_181723	NP_859074	Q86XE3	EFHA2_HUMAN	EF-hand domain family, member A2	318						integral to membrane	calcium ion binding			skin(1)	1				Colorectal(111;0.0686)|COAD - Colon adenocarcinoma(73;0.239)		AGACGTAACACAAGCCAAGCA	0.383													53	140					0	0	0	0	T	16956031	T	T	16956031	3	4	41	1	0	0	0	0	1	0	0	0	4966	478	17	4	987	4	EFHA2	8	16956031	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08		16956031	129407991	81	8745											
PIWIL2	55124	broad.mit.edu	37	chr8	22172591	22172591	+	Frame_Shift_Del	DEL	C	-	-																															caccaggcttcggagtgtggCccagaagattttacttcaga																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:22172591delC	uc003xbn.2	+	18	2289	c.2141delC	c.(2140-2142)GCCfs	p.A714fs	PIWIL2_uc011kzf.1_Frame_Shift_Del_p.A714fs|PIWIL2_uc010ltv.2_Frame_Shift_Del_p.A714fs	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	714	Piwi.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		CGGAGTGTGGCCCAGAAGATT	0.483													---	---	---								-	22172591	-	-	22172591	7	5	41	1	0	1	0	1	0	0	0	0	12013	739	26	0	2207	0	PIWIL2	8	22172591	Frame_Shift_Del	DEL	C	TCGA-CN-4729-01A-01D-1434-08	5216560	22172591	124191431	82	8746											
UNC5D	137970	broad.mit.edu	37	chr8	35608198	35608198	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctttgggacctatgcgctCactggagagccaatcacaga	11	8	11	11	1	2	2	2	0	0	2	2	4	2	3	2	2	3	2	2	2	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:35608198C>A	uc003xjr.1	+	13	2362	c.2034C>A	c.(2032-2034)CTC>CTA	p.L678L	UNC5D_uc003xjs.1_Silent_p.L673L|UNC5D_uc003xju.1_Silent_p.L254L	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	678	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCTATGCGCTCACTGGAGAGC	0.498													45	284					1.97e-11	2.17232e-11	1	0	A	35608198	A	A	35608198	2	1	41	1	0	0	0	0	0	0	0	1	17063	813	29	2		2	UNC5D	8	35608198	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	13435607	35608198	110755824	83	8747											
KIAA0146	23514	broad.mit.edu	37	chr8	48309175	48309175	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagaaaattcagcaaagaaGaagcttttaaggttaaatta	19	10	7	5	0	1	3	1	0	0	3	1	3	1	3	1	1	2	3	1	1	9	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:48309175G>C	uc003xqd.2	+	6	774	c.765G>C	c.(763-765)AAG>AAC	p.K255N	KIAA0146_uc011lcz.1_Intron|KIAA0146_uc011lda.1_Intron|KIAA0146_uc011ldb.1_Missense_Mutation_p.K255N|KIAA0146_uc010lxs.2_5'UTR|KIAA0146_uc011ldc.1_Missense_Mutation_p.K185N|KIAA0146_uc011ldd.1_Missense_Mutation_p.K195N|KIAA0146_uc003xqe.2_Intron|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Intron	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	255											0		Lung NSC(58;0.175)				CAGCAAAGAAGAAGCTTTTAA	0.313													88	174					0	0	0	0	C	48309175	C	C	48309175	3	2	41	1	0	0	0	0	1	0	0	0	8196	933	33	2	787	2	KIAA0146	8	48309175	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	12700977	48309175	98054847	84	8748											
XKR4	114786	broad.mit.edu	37	chr8	56015448	56015448	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacagacgtctggctcgccGtggactactacctgcgcggc	6	7	13	15	5	1	1	0	0	1	1	2	2	1	2	2	3	3	2	2	3	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:56015448G>A	uc003xsf.2	+	1	432	c.400G>A	c.(400-402)GTG>ATG	p.V134M		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	134	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			CTGGCTCGCCGTGGACTACTA	0.662													7	118					0	0	0	0	A	56015448	A	A	56015448	3	1	41	1	0	0	0	0	1	0	0	0	17501	1145	40	1	402	1	XKR4	8	56015448	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	7706273	56015448	90348574	85	8749											
XKR4	114786	broad.mit.edu	37	chr8	56015674	56015674	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggggaaggcgaggctcgtcCttccacgccgcaaaggcaag	9	4	15	13	5	0	0	0	0	0	0	3	2	2	1	3	5	0	3	3	5	3	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:56015674C>A	uc003xsf.2	+	1	658	c.626C>A	c.(625-627)CCT>CAT	p.P209H		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	209						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			GAGGCTCGTCCTTCCACGCCG	0.692													22	38					2.89027e-11	3.13625e-11	1	0	A	56015674	A	A	56015674	3	1	41	1	0	0	0	0	1	0	0	0	17501	681	24	4	628	4	XKR4	8	56015674	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	226	56015674	90348348	86	8750											
GSDMC	56169	broad.mit.edu	37	chr8	130789715	130789715	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacgagaatccttcttctttCgtaatataacaaactgacgt	14	13	5	9	3	2	2	0	1	2	1	4	3	3	2	1	0	3	1	1	0	6	6			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:130789715C>T	uc003ysr.2	-	2	1001	c.119G>A	c.(118-120)CGA>CAA	p.R40Q		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	40						mitochondrion				ovary(2)|skin(1)	3						CTTCTTCTTTCGTAATATAAC	0.398													30	174					0	0	0	0	T	130789715	T	T	130789715	3	4	41	1	0	0	0	0	1	0	0	0	6857	884	31	1	1459	1	GSDMC	8	130789715	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	74774041	130789715	15574307	87	8751											
FAM135B	51059	broad.mit.edu	37	chr8	139180196	139180196	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accggcagggtgttccaatcGccgtcgatgtccaggcactc	7	8	12	14	4	0	0	0	0	0	0	5	1	2	0	4	3	0	3	4	3	1	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr8:139180196G>T	uc003yuy.2	-	12	1371	c.1200C>A	c.(1198-1200)GGC>GGA	p.G400G	FAM135B_uc003yux.2_Silent_p.G301G|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	400										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGTTCCAATCGCCGTCGATGT	0.552										HNSCC(54;0.14)			60	159					5.10652e-33	6.02156e-33	1	0	T	139180196	T	T	139180196	2	4	41	1	0	0	0	0	0	0	0	1	5477	1074	38	3		3	FAM135B	8	139180196	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	8390481	139180196	7183826	88	8752											
NTRK2	4915	broad.mit.edu	37	chr9	87339210	87339210	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgacagtgggaagcagatCtcttgtgtggcggaaaatct	11	10	14	6	1	2	2	0	1	2	1	3	5	2	4	0	3	1	1	0	3	3	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr9:87339210C>G	uc004aoa.1	+	10	1730	c.792C>G	c.(790-792)ATC>ATG	p.I264M	NTRK2_uc004anv.1_Missense_Mutation_p.I264M|NTRK2_uc004any.1_Missense_Mutation_p.I264M|NTRK2_uc004anz.1_Missense_Mutation_p.I264M|NTRK2_uc011lsz.1_Missense_Mutation_p.I264M|NTRK2_uc011lta.1_Missense_Mutation_p.I264M|NTRK2_uc004aob.1_Missense_Mutation_p.I264M|NTRK2_uc011ltb.1_Missense_Mutation_p.I108M	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	264	Extracellular (Potential).|Ig-like C2-type 1.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						GGAAGCAGATCTCTTGTGTGG	0.393										TSP Lung(25;0.17)			12	249					0	0	0	0	G	87339210	G	G	87339210	3	3	41	1	0	0	0	0	1	0	0	0	10761	903	32	2	818	2	NTRK2	9	87339210	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08		87339210	53874221	89	8753											
CTNNAL1	8727	broad.mit.edu	37	chr9	111745497	111745497	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccattcggtttacagtcagtCacaatttcaatgaccttatc	11	14	5	11	1	3	1	3	1	0	0	5	1	3	1	2	1	1	1	2	1	4	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr9:111745497C>T	uc004bdo.1	-	6	870	c.828G>A	c.(826-828)GTG>GTA	p.V276V	CTNNAL1_uc010mts.1_Silent_p.V12V|CTNNAL1_uc010mtt.1_Silent_p.V276V|CTNNAL1_uc004bdp.1_Silent_p.V276V	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	276					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		TACAGTCAGTCACAATTTCAA	0.353													6	64					0	0	0	0	T	111745497	T	T	111745497	2	4	41	1	0	0	0	0	0	0	0	1	4032	813	29	2		2	CTNNAL1	9	111745497	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	24406287	111745497	29467934	90	8754											
NOTCH1	4851	broad.mit.edu	37	chr9	139402755	139402755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccggtccagccgctggggCactcgcagcggtactgggtg	4	6	18	13	4	0	0	0	0	0	0	2	0	1	0	3	6	3	4	3	6	1	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr9:139402755C>T	uc004chz.2	-	20	3254	c.3254G>A	c.(3253-3255)TGC>TAC	p.C1085Y	NOTCH1_uc004cia.1_Missense_Mutation_p.C315Y	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1085	Extracellular (Potential).|EGF-like 28.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCCGCTGGGGCACTCGCAGCG	0.647			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			33	58					0	0	0	0	T	139402755	T	T	139402755	3	4	41	1	0	0	0	0	1	0	0	0	10601	710	25	4	4473	4	NOTCH1	9	139402755	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	27657258	139402755	1810676	91	8755											
ANKRD26	22852	broad.mit.edu	37	chr10	27324102	27324102	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttttgtacccgttctaaacCcaaagtcttttctctgaggg	8	15	7	11	1	3	1	0	1	3	0	4	1	3	1	2	1	2	2	2	1	4	7			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr10:27324102C>T	uc001ith.2	-	24	3446	c.3274G>A	c.(3274-3276)GGT>AGT	p.G1092S	ANKRD26_uc001itg.2_Missense_Mutation_p.G779S|ANKRD26_uc009xku.1_Missense_Mutation_p.G1093S	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1092	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						CGTTCTAAACCCAAAGTCTTT	0.348													17	226					0	0	0	0	T	27324102	T	T	27324102	3	4	41	1	0	0	0	0	1	0	0	0	654	623	22	4	1899	4	ANKRD26	10	27324102	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08		27324102	108210645	92	8756											
SVIL	6840	broad.mit.edu	37	chr10	29776096	29776096	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttcaggtaccaaccttcGccttttctatgacgtttgca	7	17	6	11	2	2	1	1	1	1	0	3	1	2	1	3	1	3	3	3	1	3	8			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr10:29776096G>A	uc001iut.1	-	24	5234	c.4481C>T	c.(4480-4482)GCG>GTG	p.A1494V	LOC387647_uc001iuq.1_RNA|SVIL_uc010qdw.1_Missense_Mutation_p.A408V|SVIL_uc001iuu.1_Missense_Mutation_p.A1068V|SVIL_uc009xlc.2_Missense_Mutation_p.A286V	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1494	Gelsolin-like 1.|Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				ACCAACCTTCGCCTTTTCTAT	0.502													6	29					0	0	0	0	A	29776096	A	A	29776096	3	1	41	1	0	0	0	0	1	0	0	0	15487	1087	38	1	2223	1	SVIL	10	29776096	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	2451994	29776096	105758651	93	8757											
SLC16A9	220963	broad.mit.edu	37	chr10	61413786	61413788	+	In_Frame_Del	DEL	CTT	-	-																															cttcttctttcacgtttgaaCttcttgctacatcttccata																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr10:61413786_61413788delCTT	uc010qig.1	-	5	1445_1447	c.996_998delAAG	c.(994-999)AGAAGT>AGT	p.R332del		NM_194298	NP_919274	Q7RTY1	MOT9_HUMAN	solute carrier family 16 (monocarboxylic acid	332	Cytoplasmic (Potential).				urate metabolic process	integral to membrane|plasma membrane	symporter activity			skin(2)|ovary(1)	3						CACGTTTGAACTTCTTGCTACAT	0.365													---	---	---								-	61413788	-	-	61413786	7	5	41	1	0	1	0	1	0	0	0	0	14480	565	20	0	539	0	SLC16A9	10	61413786	In_Frame_Del	DEL	CTT	TCGA-CN-4729-01A-01D-1434-08	31637690	61413786	74120961	94	8758											
MMRN2	79812	broad.mit.edu	37	chr10	88696664	88696664	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgcccagtggtacagactgGagtccgatggtgacctccaa	9	8	12	12	1	0	2	0	1	0	1	2	4	2	3	4	3	2	1	4	3	2	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr10:88696664G>A	uc001kea.2	-	7	2813	c.2686C>T	c.(2686-2688)CCA>TCA	p.P896S	MMRN2_uc010qmn.1_Missense_Mutation_p.P539S	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	896	C1q.					extracellular space				large_intestine(1)	1						GTACAGACTGGAGTCCGATGG	0.597													29	275					0	0	0	0	A	88696664	A	A	88696664	3	1	41	1	0	0	0	0	1	0	0	0	9724	1174	41	2	167	2	MMRN2	10	88696664	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	27282878	88696664	46838083	95	8759											
GPR120	338557	broad.mit.edu	37	chr10	95326706	95326706	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgcggcgcgactgcctgcCtggtactcaacctcttctgc	4	9	11	17	4	3	0	1	0	2	0	3	1	3	0	4	2	5	1	4	2	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr10:95326706C>A	uc010qnt.1	+	1	285	c.229C>A	c.(229-231)CTG>ATG	p.L77M	GPR120_uc010qnu.1_Missense_Mutation_p.L77M	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	G protein-coupled receptor 120	77	Cytoplasmic (Potential).				negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding				0		Colorectal(252;0.122)				GACTGCCTGCCTGGTACTCAA	0.677													3	43					0.004672	0.00478939	1	0	A	95326706	A	A	95326706	3	1	41	1	0	0	0	0	1	0	0	0	6674	680	24	4	231	4	GPR120	10	95326706	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	6630042	95326706	40208041	96	8760											
TRIM21	6737	broad.mit.edu	37	chr11	4409647	4409647	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcccccaggattctcagctgCtccctctcatccttctccag	5	12	5	19	0	3	0	2	0	3	0	9	1	6	1	5	1	2	2	5	1	0	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:4409647C>T	uc001lyy.1	-	4	731	c.618G>A	c.(616-618)GAG>GAA	p.E206E		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	206	Potential.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		TTCTCAGCTGCTCCCTCTCAT	0.542													86	204					0	0	0	0	T	4409647	T	T	4409647	2	4	41	1	0	0	0	0	0	0	0	1	16562	796	28	4		4	TRIM21	11	4409647	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08		4409647	130596869	97	8761											
TCP11L1	55346	broad.mit.edu	37	chr11	33079527	33079527	+	Frame_Shift_Del	DEL	G	-	-																															aaccagataacagaagtcttGgatctggatctgataaagca																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:33079527delG	uc001mud.2	+	5	880	c.480delG	c.(478-480)TTGfs	p.L160fs	TCP11L1_uc009yju.2_5'UTR|TCP11L1_uc010rei.1_Frame_Shift_Del_p.L160fs|TCP11L1_uc001mue.2_Frame_Shift_Del_p.L160fs|TCP11L1_uc001muf.1_5'Flank	NM_018393	NP_060863	Q9NUJ3	T11L1_HUMAN	t-complex 11 (mouse) like 1	160											0						CAGAAGTCTTGGATCTGGATC	0.433													---	---	---								-	33079527	-	-	33079527	7	5	41	1	0	1	0	1	0	0	0	0	15780	1339	47	0	494	0	TCP11L1	11	33079527	Frame_Shift_Del	DEL	G	TCGA-CN-4729-01A-01D-1434-08	28669880	33079527	101926989	98	8762											
SLC43A1	8501	broad.mit.edu	37	chr11	57261527	57261527	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatgaaggcatccgaaccGtcctccaggctgggggcctt	8	7	13	13	2	0	1	0	1	0	0	3	3	3	1	5	4	1	2	5	4	2	1	rs146290858	byFrequency	TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:57261527G>A	uc001nkk.2	-	8	928	c.810C>T	c.(808-810)GAC>GAT	p.D270D	SLC43A1_uc001nkl.2_Silent_p.D270D	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	270					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						CATCCGAACCGTCCTCCAGGC	0.612											OREG0020651	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	58					0	0	0	0	A	57261527	A	A	57261527	2	1	41	1	0	0	0	0	0	0	0	1	14696	1136	40	1		1	SLC43A1	11	57261527	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	24182000	57261527	77744989	99	8763											
ZFP91	80829	broad.mit.edu	37	chr11	58379154	58379154	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaattaaagtggaagtagAggtggaggtgaaagaagagg	17	6	18	0	0	0	4	0	1	0	3	0	7	0	7	0	6	0	1	0	6	7	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:58379154A>T	uc001nmx.3	+	6	968	c.800A>T	c.(799-801)GAG>GTG	p.E267V	ZFP91_uc001nmy.3_Missense_Mutation_p.E266V|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	267	Glu-rich.				activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				gtggaagtagaggtggaggtg	0.189													5	35					0	0	0	0	T	58379154	T	T	58379154	3	4	41	1	0	0	0	0	1	0	0	0	17722	304	11	5	822	5	ZFP91	11	58379154	Missense_Mutation	SNP	A	TCGA-CN-4729-01A-01D-1434-08	1117627	58379154	76627362	100	8764											
MRPL49	740	broad.mit.edu	37	chr11	64893285	64893285	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgaggtgacaggtaccctaCggatcaagggctactttgac	11	9	12	9	1	1	3	1	3	0	0	1	4	1	4	1	4	3	2	1	4	4	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:64893285C>A	uc001oda.1	+	4	533	c.442C>A	c.(442-444)CGG>AGG	p.R148R	MRPL49_uc001ocz.1_RNA	NM_004927	NP_004918	Q13405	RM49_HUMAN	mitochondrial ribosomal protein L49	148					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome				0						AGGTACCCTACGGATCAAGGG	0.567													37	140					3.33393e-15	3.79957e-15	1	0	A	64893285	A	A	64893285	2	1	41	1	0	0	0	0	0	0	0	1	9866	527	19	3		3	MRPL49	11	64893285	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	6514131	64893285	70113231	101	8765											
ODZ4	26011	broad.mit.edu	37	chr11	78443447	78443447	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagacgactgggttggggcGggcaaaattgctcaggtcac	10	7	16	8	2	2	1	2	0	0	1	2	3	2	1	0	5	1	3	0	5	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:78443447G>A	uc001ozl.3	-	21	3515	c.3052C>T	c.(3052-3054)CGC>TGC	p.R1018C		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1018	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GGGTTGGGGCGGGCAAAATTG	0.552													15	35					0	0	0	0	A	78443447	A	A	78443447	3	1	41	1	0	0	0	0	1	0	0	0	10891	1116	39	1	5313	1	ODZ4	11	78443447	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	13550162	78443447	56563069	102	8766											
FAT3	120114	broad.mit.edu	37	chr11	92523277	92523277	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acactgttcatagcagcatcGactccatcagcatgagaaaa	15	8	7	11	1	2	1	2	1	0	1	4	3	3	1	1	0	3	4	1	0	3	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:92523277G>C	uc001pdj.3	+	7	4521	c.4504G>C	c.(4504-4506)GAC>CAC	p.D1502H		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1502	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TAGCAGCATCGACTCCATCAG	0.507										TCGA Ovarian(4;0.039)			20	182					0	0	0	0	C	92523277	C	C	92523277	3	2	41	1	0	0	0	0	1	0	0	0	5723	1058	37	3	4530	3	FAT3	11	92523277	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	14079830	92523277	42483239	103	8767											
FAT3	120114	broad.mit.edu	37	chr11	92534060	92534060	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caagttcaagccatagatccCgatgatggagcaaattcaag	15	8	9	9	1	2	2	2	1	0	1	3	4	3	3	2	1	2	2	2	1	5	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:92534060C>T	uc001pdj.3	+	9	7898	c.7881C>T	c.(7879-7881)CCC>CCT	p.P2627P		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2627	Cadherin 24.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCATAGATCCCGATGATGGAG	0.498										TCGA Ovarian(4;0.039)			9	20					0	0	0	0	T	92534060	T	T	92534060	2	4	41	1	0	0	0	0	0	0	0	1	5723	639	23	1		1	FAT3	11	92534060	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	10783	92534060	42472456	104	8768											
CNTN5	53942	broad.mit.edu	37	chr11	99690441	99690441	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctggctaggggcagctcaGaattattattcccccatcaa	11	10	9	11	0	2	1	2	0	0	1	3	1	3	1	2	3	2	4	2	3	5	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:99690441G>A	uc001pga.2	+	4	561	c.222G>A	c.(220-222)CAG>CAA	p.Q74Q	CNTN5_uc009ywv.1_Silent_p.Q74Q|CNTN5_uc001pfz.2_Silent_p.Q74Q|CNTN5_uc001pgb.2_Intron	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	74					cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GGGCAGCTCAGAATTATTATT	0.363													3	28					0	0	0	0	A	99690441	A	A	99690441	2	1	41	1	0	0	0	0	0	0	0	1	3659	933	33	2		2	CNTN5	11	99690441	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	7156381	99690441	35316075	105	8769											
FAM55A	120400	broad.mit.edu	37	chr11	114392969	114392969	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaatagccttttgaacaccGatggccctgcgaataaaaat	14	10	7	10	2	1	1	1	1	0	0	1	3	1	1	3	1	3	0	3	1	7	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:114392969G>A	uc001ppa.2	-	6	1356	c.939C>T	c.(937-939)ATC>ATT	p.I313I	FAM55A_uc010rxd.1_Silent_p.I162I	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	455						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		TTTGAACACCGATGGCCCTGC	0.433													10	89					0	0	0	0	A	114392969	A	A	114392969	2	1	41	1	0	0	0	0	0	0	0	1	5616	1048	37	1		1	FAM55A	11	114392969	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	14702528	114392969	20613547	106	8770											
PKNOX2	63876	broad.mit.edu	37	chr11	125301235	125301235	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggaggaggtcgacgagctgCagacgacaaatgtcagcgac	13	4	15	9	4	1	1	1	0	0	1	2	7	1	3	0	3	3	2	0	3	1	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:125301235C>T	uc001qbu.2	+	13	1680	c.1366C>T	c.(1366-1368)CAG>TAG	p.Q456*	PKNOX2_uc010saz.1_Nonsense_Mutation_p.Q427*|PKNOX2_uc010sba.1_Nonsense_Mutation_p.Q427*|PKNOX2_uc010sbb.1_Nonsense_Mutation_p.Q392*|PKNOX2_uc001qbv.2_Nonsense_Mutation_p.Q221*	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	456						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CGACGAGCTGCAGACGACAAA	0.413													4	41					0	0	0	0	T	125301235	T	T	125301235	4	4	41	1	0	0	0	0	0	1	0	0	12038	711	25	4	1404	4	PKNOX2	11	125301235	Nonsense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	10908266	125301235	9705281	107	8771											
SRPR	6734	broad.mit.edu	37	chr11	126137475	126137475	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggaagtcattttggaaatCaaaagtgccatttaataaac	17	11	7	6	0	2	0	2	0	0	0	2	2	2	2	1	2	2	0	1	2	7	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr11:126137475C>G	uc001qdh.2	-	3	385	c.334G>C	c.(334-336)GAT>CAT	p.D112H	SRPR_uc010sbm.1_Missense_Mutation_p.D84H|FOXRED1_uc001qdi.2_5'Flank|FOXRED1_uc010sbn.1_5'Flank|FOXRED1_uc010sbo.1_5'Flank|FOXRED1_uc010sbp.1_5'Flank|FOXRED1_uc010sbq.1_5'Flank|FOXRED1_uc001qdj.2_5'Flank|FOXRED1_uc010sbr.1_5'Flank	NM_003139	NP_003130	P08240	SRPR_HUMAN	signal recognition particle receptor	112					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding				0	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		TTTTGGAAATCAAAAGTGCCA	0.418													10	106					0	0	0	0	G	126137475	G	G	126137475	3	3	41	1	0	0	0	0	1	0	0	0	15228	826	29	2	1630	2	SRPR	11	126137475	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	836240	126137475	8869041	108	8772											
IQSEC3	440073	broad.mit.edu	37	chr12	247993	247993	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgatggctttccgggacgtCacggtgcagatcgccaacca	9	8	12	12	4	1	2	1	1	0	1	3	3	2	3	3	3	2	2	3	3	1	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:247993C>T	uc001qhw.1	+	1	561	c.555C>T	c.(553-555)GTC>GTT	p.V185V	IQSEC3_uc001qhu.1_Silent_p.V185V|IQSEC3_uc001qht.1_Silent_p.V270V|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	488					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TCCGGGACGTCACGGTGCAGA	0.587													5	19					0	0	0	0	T	247993	T	T	247993	2	4	41	1	0	0	0	0	0	0	0	1	7858	813	29	2		2	IQSEC3	12	247993	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08		247993	133603902	109	8773											
CACNA1C	775	broad.mit.edu	37	chr12	2659197	2659197	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaaactgcggggccaggctGgcgtgagtaggcacggcgag	9	4	19	9	4	0	1	0	1	0	0	0	3	0	1	1	6	2	3	1	6	3	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:2659197G>T	uc009zdu.1	+	10	1792	c.1479G>T	c.(1477-1479)CTG>CTT	p.L493L	CACNA1C_uc009zdv.1_Silent_p.L490L|CACNA1C_uc001qkb.2_Silent_p.L493L|CACNA1C_uc001qkc.2_Silent_p.L493L|CACNA1C_uc001qke.2_Silent_p.L493L|CACNA1C_uc001qkf.2_Silent_p.L493L|CACNA1C_uc001qjz.2_Silent_p.L493L|CACNA1C_uc001qkd.2_Silent_p.L493L|CACNA1C_uc001qkg.2_Silent_p.L493L|CACNA1C_uc009zdw.1_Silent_p.L493L|CACNA1C_uc001qkh.2_Silent_p.L493L|CACNA1C_uc001qkl.2_Silent_p.L493L|CACNA1C_uc001qkn.2_Silent_p.L493L|CACNA1C_uc001qko.2_Silent_p.L493L|CACNA1C_uc001qkp.2_Silent_p.L493L|CACNA1C_uc001qkr.2_Silent_p.L493L|CACNA1C_uc001qku.2_Silent_p.L493L|CACNA1C_uc001qkq.2_Silent_p.L493L|CACNA1C_uc001qks.2_Silent_p.L493L|CACNA1C_uc001qkt.2_Silent_p.L493L|CACNA1C_uc001qka.1_Silent_p.L28L|CACNA1C_uc001qki.1_Silent_p.L229L|CACNA1C_uc001qkj.1_Silent_p.L229L|CACNA1C_uc001qkk.1_Silent_p.L229L|CACNA1C_uc001qkm.1_Silent_p.L229L|CACNA1C_uc009zdy.1_Silent_p.L118L|CACNA1C_uc001qkv.1_Silent_p.L63L	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	493	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGGCCAGGCTGGCGTGAGTAG	0.592													9	10					4.68919e-08	4.95645e-08	1	0	T	2659197	T	T	2659197	2	4	41	1	0	0	0	0	0	0	0	1	2552	1335	47	4		4	CACNA1C	12	2659197	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	2411204	2659197	131192698	110	8774											
SLC2A3	6515	broad.mit.edu	37	chr12	8075605	8075605	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaatacagacaaagctcaTcccattatagttatcctgta	14	11	4	12	0	1	1	1	0	0	1	3	1	3	1	3	0	2	3	3	0	7	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:8075605T>A	uc001qtr.2	-	9	1346	c.1084A>T	c.(1084-1086)ATG>TTG	p.M362L		NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	362	Extracellular (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		ACAAAGCTCATCCCATTATAG	0.423													8	40					0	0	0	0	A	8075605	A	A	8075605	3	1	41	1	0	0	0	0	1	0	0	0	14609	1435	50	5	414	5	SLC2A3	12	8075605	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	5416408	8075605	125776290	111	8775											
SENP1	29843	broad.mit.edu	37	chr12	48457609	48457609	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attacgaaatacattctttaTttctttctccatttcctaag	11	19	2	9	1	3	0	0	0	3	0	5	1	4	0	2	0	2	0	2	0	5	9			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:48457609T>A	uc001rqx.2	-	13	1737	c.1291A>T	c.(1291-1293)ATA>TTA	p.I431L	SENP1_uc001rqw.2_Missense_Mutation_p.I431L|SENP1_uc001rqy.2_Missense_Mutation_p.I232L|SENP1_uc001rqz.2_Missense_Mutation_p.I232L|SENP1_uc009zkx.2_Missense_Mutation_p.I431L	NM_014554	NP_055369	Q9P0U3	SENP1_HUMAN	sentrin/SUMO-specific protease 1	431					activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			pancreas(2)|lung(1)	3		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				ACATTCTTTATTTCTTTCTCC	0.383													10	22					0	0	0	0	A	48457609	A	A	48457609	3	1	41	1	0	0	0	0	1	0	0	0	14111	1493	52	5	664	5	SENP1	12	48457609	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	40382004	48457609	85394286	112	8776											
STAC3	246329	broad.mit.edu	37	chr12	57640593	57640593	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtacagtgctcacatttttCttatctgcctgtcccttctt	5	18	6	12	0	4	0	1	0	3	0	5	0	5	0	2	1	3	2	2	1	2	6			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:57640593C>G	uc001snp.2	-	6	792	c.597G>C	c.(595-597)AAG>AAC	p.K199N	STAC3_uc009zpl.2_5'UTR|STAC3_uc001snq.2_Missense_Mutation_p.K160N|STAC3_uc010srm.1_Missense_Mutation_p.K13N	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	199					intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						TCACATTTTTCTTATCTGCCT	0.498													23	325					0	0	0	0	G	57640593	G	G	57640593	3	3	41	1	0	0	0	0	1	0	0	0	15307	912	32	2	525	2	STAC3	12	57640593	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	9182984	57640593	76211302	113	8777											
HELB	92797	broad.mit.edu	37	chr12	66696407	66696408	+	Missense_Mutation	DNP	GC	TT	TT																															gccaggtcgagtccgtacctGcgccaacttcagggacctct																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr12:66696407_66696408GC>TT	uc001sti.2	+	1	52_53	c.24_25GC>TT	c.(22-27)CTGCGC>CTTTGC	p.R9C	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	9					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		GTCCGTACCTGCGCCAACTTCA	0.55													17	91					0	0	0	0	TT	66696408	TT	TT	66696407	3	4	41	1	0	0	0	0	1	0	0	0	7084	1306	46	4	26	4	HELB	12	66696407	Missense_Mutation	DNP	GC	TCGA-CN-4729-01A-01D-1434-08	9055814	66696407	67155488	114	8778											
NBEA	26960	broad.mit.edu	37	chr13	36129126	36129126	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgtgcttaattgctaggaGgatatcattggccactcctc	8	13	10	10	0	1	0	1	0	0	0	3	2	2	2	2	3	2	3	2	3	3	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr13:36129126G>A	uc001uvb.2	+	44	7015	c.6809G>A	c.(6808-6810)AGG>AAG	p.R2270K	NBEA_uc010abi.2_Missense_Mutation_p.R926K|NBEA_uc010tee.1_Missense_Mutation_p.R63K|NBEA_uc010tef.1_Missense_Mutation_p.R63K|NBEA_uc010teg.1_Missense_Mutation_p.R63K	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2270						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ATTGCTAGGAGGATATCATTG	0.318													6	45					0	0	0	0	A	36129126	A	A	36129126	3	1	41	1	0	0	0	0	1	0	0	0	10240	1000	35	4	6983	4	NBEA	13	36129126	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08		36129126	79040752	115	8779											
CCDC70	83446	broad.mit.edu	37	chr13	52439668	52439668	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcaggaggaaaaggcttttCgcgaagagatgaaaattttt	14	11	12	4	2	0	2	0	1	0	1	1	6	0	4	0	3	1	2	0	3	5	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr13:52439668C>T	uc001vfu.3	+	2	450	c.154C>T	c.(154-156)CGC>TGC	p.R52C	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	52						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		AAAGGCTTTTCGCGAAGAGAT	0.517													26	173					0	0	0	0	T	52439668	T	T	52439668	3	4	41	1	0	0	0	0	1	0	0	0	2856	884	31	1	156	1	CCDC70	13	52439668	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	16310542	52439668	62730210	116	8780											
NEK5	341676	broad.mit.edu	37	chr13	52660423	52660423	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaatttacctctggttctCtccccatcttctttctaatt	7	19	3	12	0	5	1	0	1	5	0	7	1	6	1	3	1	1	1	3	1	3	7			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr13:52660423C>G	uc001vge.2	-	16	1609	c.1469G>C	c.(1468-1470)AGA>ACA	p.R490T		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	490							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CTCTGGTTCTCTCCCCATCTT	0.363													17	215					0	0	0	0	G	52660423	G	G	52660423	3	3	41	1	0	0	0	0	1	0	0	0	10381	913	32	2	685	2	NEK5	13	52660423	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	220755	52660423	62509455	117	8781											
PCDH17	27253	broad.mit.edu	37	chr13	58207106	58207106	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagatcgaaatggacatctcGgagaacgctgctccgggcac	11	6	12	12	4	1	2	0	0	1	2	4	5	2	3	1	3	2	3	1	3	2	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr13:58207106G>A	uc001vhq.1	+	1	1318	c.426G>A	c.(424-426)TCG>TCA	p.S142S	PCDH17_uc010aec.1_Silent_p.S142S	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	142	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGGACATCTCGGAGAACGCTG	0.617													21	24					0	0	0	0	A	58207106	A	A	58207106	2	1	41	1	0	0	0	0	0	0	0	1	11566	1103	39	1		1	PCDH17	13	58207106	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	5546683	58207106	56962772	118	8782											
EFS	10278	broad.mit.edu	37	chr14	23826643	23826643	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggggcagaggctgccagcCggcccagggtgtccccaaca	8	3	16	14	1	0	1	0	0	0	1	1	2	1	1	5	5	3	2	5	5	1	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr14:23826643C>T	uc001wjo.2	-	6	2086	c.1478G>A	c.(1477-1479)CGG>CAG	p.R493Q	EFS_uc001wjp.2_Missense_Mutation_p.R400Q|EFS_uc010tnm.1_Missense_Mutation_p.R324Q	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	493					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GGCTGCCAGCCGGCCCAGGGT	0.657													19	42					0	0	0	0	T	23826643	T	T	23826643	3	4	41	1	0	0	0	0	1	0	0	0	4981	652	23	1	211	1	EFS	14	23826643	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08		23826643	83522897	119	8783											
AKAP6	9472	broad.mit.edu	37	chr14	33147632	33147632	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgaaaggaagagtttgctgAtatgtcaaaagttcattcag	14	11	11	5	1	3	2	3	1	0	1	3	4	3	3	0	1	1	3	0	1	5	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr14:33147632A>T	uc001wrq.2	+	8	3016	c.2846A>T	c.(2845-2847)GAT>GTT	p.D949V	AKAP6_uc010aml.2_Missense_Mutation_p.D946V	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	949					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GAGTTTGCTGATATGTCAAAA	0.413													36	105					0	0	0	0	T	33147632	T	T	33147632	3	4	41	1	0	0	0	0	1	0	0	0	455	333	12	5	2872	5	AKAP6	14	33147632	Missense_Mutation	SNP	A	TCGA-CN-4729-01A-01D-1434-08	9320989	33147632	74201908	120	8784											
FRMD6	122786	broad.mit.edu	37	chr14	52194513	52194513	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatcgacacagcttgagcctCgatgacatcagactttacca	12	9	8	12	2	1	3	1	2	0	1	3	6	1	3	2	0	3	1	2	0	1	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr14:52194513C>T	uc001wzd.2	+	14	1920	c.1635C>T	c.(1633-1635)CTC>CTT	p.L545L	FRMD6_uc001wzb.2_Silent_p.L537L|FRMD6_uc001wzc.2_Silent_p.L537L|FRMD6_uc001wze.2_Silent_p.L468L|FRMD6_uc001wzf.2_Silent_p.L238L|FRMD6_uc001wzg.2_Silent_p.L187L	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	545						cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					GCTTGAGCCTCGATGACATCA	0.453													10	148					0	0	0	0	T	52194513	T	T	52194513	2	4	41	1	0	0	0	0	0	0	0	1	6088	871	31	1		1	FRMD6	14	52194513	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	19046881	52194513	55155027	121	8785											
PIF1	80119	broad.mit.edu	37	chr15	65114583	65114583	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgctttagcagatatgacttCcctgttcctggacaggggca	8	11	11	11	1	0	2	0	1	0	1	2	3	2	3	2	3	1	4	2	3	2	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:65114583C>T	uc002ant.2	-	4	765	c.699G>A	c.(697-699)GGG>GGA	p.G233G	PIF1_uc002anr.2_5'Flank|PIF1_uc002ans.2_5'Flank|PIF1_uc010uiq.1_Silent_p.G233G|PIF1_uc002anu.2_Missense_Mutation_p.G262E	NM_025049	NP_079325	Q9H611	PIF1_HUMAN	DNA helicase homolog PIF1	233	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.|ATP (Potential).				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding				0						GATATGACTTCCCTGTTCCTG	0.617													38	72					0	0	0	0	T	65114583	T	T	65114583	2	4	41	1	0	0	0	0	0	0	0	1	11938	842	30	2		2	PIF1	15	65114583	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08		65114583	37416809	122	8786											
UACA	55075	broad.mit.edu	37	chr15	70960340	70960340	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttatttttacaaattcctGatttatatcttcaaattttt	11	24	1	5	0	2	1	1	1	1	0	3	1	3	1	1	0	1	0	1	0	6	12			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:70960340G>C	uc002asr.2	-	16	2787	c.2683C>G	c.(2683-2685)CAG>GAG	p.Q895E	UACA_uc010uke.1_Missense_Mutation_p.Q786E|UACA_uc002asq.2_Missense_Mutation_p.Q882E|UACA_uc010bin.1_Missense_Mutation_p.Q870E	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	895	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						ACAAATTCCTGATTTATATCT	0.308													11	33					0	0	0	0	C	70960340	C	C	70960340	3	2	41	1	0	0	0	0	1	0	0	0	16892	1299	45	2	1583	2	UACA	15	70960340	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	5845757	70960340	31571052	123	8787											
SEMA7A	8482	broad.mit.edu	37	chr15	74707066	74707066	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggaaggtctctgtgggtatCggctgctggtctgggaggca	5	11	18	7	1	2	0	0	0	2	0	4	2	2	2	0	7	1	4	0	7	2	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:74707066C>T	uc002axv.2	-	10	1156	c.1116G>A	c.(1114-1116)CCG>CCA	p.P372P	SEMA7A_uc010ulk.1_Silent_p.P207P|SEMA7A_uc010ull.1_Silent_p.P358P	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	372	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						CTGTGGGTATCGGCTGCTGGT	0.652													42	117					0	0	0	0	T	74707066	T	T	74707066	2	4	41	1	0	0	0	0	0	0	0	1	14108	871	31	1		1	SEMA7A	15	74707066	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	3746726	74707066	27824326	124	8788											
CTSH	1512	broad.mit.edu	37	chr15	79231500	79231500	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accttagacatccatgacttGaagtgaaacttctctgtaaa	14	12	6	9	0	1	4	0	3	1	1	3	4	2	4	2	0	1	1	2	0	5	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:79231500G>A	uc002ben.2	-	3	166	c.69C>T	c.(67-69)TTC>TTT	p.F23F	CTSH_uc010unf.1_RNA|CTSH_uc010bll.1_Intron|CTSH_uc010ung.1_Silent_p.F35F	NM_148979	NP_683880	P09668	CATH_HUMAN	cathepsin H isoform b precursor	35					protein destabilization|proteolysis	lysosome	cysteine-type endopeptidase activity			central_nervous_system(2)|large_intestine(1)	3						TCCATGACTTGAAGTGAAACT	0.368													9	60					0	0	0	0	A	79231500	A	A	79231500	2	1	41	1	0	0	0	0	0	0	0	1	4053	1281	45	2		2	CTSH	15	79231500	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	4524434	79231500	23299892	125	8789											
KIAA1199	57214	broad.mit.edu	37	chr15	81224351	81224351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagctgcccccataacaacGtgaccggcattgcctttgag	10	8	10	13	2	0	3	0	2	0	1	0	3	0	3	4	1	5	2	4	1	2	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:81224351G>A	uc002bfw.1	+	21	3024	c.2764G>A	c.(2764-2766)GTG>ATG	p.V922M	KIAA1199_uc010unn.1_Missense_Mutation_p.V922M	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	922										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CCATAACAACGTGACCGGCAT	0.602													52	217					0	0	0	0	A	81224351	A	A	81224351	3	1	41	1	0	0	0	0	1	0	0	0	8252	1145	40	1	2842	1	KIAA1199	15	81224351	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	1992851	81224351	21307041	126	8790											
PEX11A	8800	broad.mit.edu	37	chr15	90229778	90229778	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcatgtgtactgagtggctCtgaaatggaaaaaaaaaaat	17	10	10	4	0	1	2	0	2	1	0	1	3	1	3	0	2	2	3	0	2	7	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr15:90229778C>G	uc002boi.2	-	2	152	c.57_splice	c.e2-1	p.R19_splice	PEX11A_uc010upy.1_Intron	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha						cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CTGAGTGGCTCTGAAATGGAA	0.378													15	169					0	0	0	0	G	90229778	G	G	90229778	5	3	41	1	0	0	0	0	0	0	1	0	11792	927	32	2	695	2	PEX11A	15	90229778	Splice_Site	SNP	C	TCGA-CN-4729-01A-01D-1434-08	9005427	90229778	12301614	127	8791											
TUFM	7284	broad.mit.edu	37	chr16	28856350	28856350	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accaccaggatgcagccgtcGaggggtgcagtgcctgtgat	8	7	15	11	2	0	1	0	1	0	0	1	3	0	2	4	3	4	2	4	3	0	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr16:28856350G>A	uc002drh.2	-	4	580	c.441C>T	c.(439-441)CTC>CTT	p.L147L	uc010vct.1_Intron|SH2B1_uc002dri.2_5'Flank	NM_003321	NP_003312	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	144						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			ovary(1)	1						TGCAGCCGTCGAGGGGTGCAG	0.542													18	85					0	0	0	0	A	28856350	A	A	28856350	2	1	41	1	0	0	0	0	0	0	0	1	16839	1045	37	1		1	TUFM	16	28856350	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08		28856350	61498403	128	8792											
NLRC5	84166	broad.mit.edu	37	chr16	57088721	57088721	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggccaacaccttaagcCtgtgtccacgggttaaaaag	11	9	10	11	1	0	0	0	0	0	0	1	0	1	0	4	2	3	2	4	2	5	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr16:57088721C>T	uc002ekk.1	+	25	3790	c.3565C>T	c.(3565-3567)CTG>TTG	p.L1189L	NLRC5_uc002ekn.2_Silent_p.L908L|NLRC5_uc002ekl.2_Silent_p.L994L|NLRC5_uc002ekm.2_Silent_p.L964L|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekp.1_Silent_p.L105L|NLRC5_uc002ekq.1_5'UTR|NLRC5_uc002ekr.1_Silent_p.L105L	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1189					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CACCTTAAGCCTGTGTCCACG	0.577													99	297					0	0	0	0	T	57088721	T	T	57088721	2	4	41	1	0	0	0	0	0	0	0	1	10524	680	24	4		4	NLRC5	16	57088721	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	28232371	57088721	33266032	129	8793											
ZNF319	57567	broad.mit.edu	37	chr16	58030907	58030907	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagggccgctcggccgcgccGggcaggcacttgtgccgcag	5	4	17	15	6	0	0	0	0	0	0	1	0	0	0	4	4	1	4	4	4	1	1	rs150126886		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr16:58030907G>A	uc002emx.1	-	2	1886	c.1263C>T	c.(1261-1263)CCC>CCT	p.P421P		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	421	C2H2-type 11; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGGCCGCGCCGGGCAGGCACT	0.662													7	55					0	0	0	0	A	58030907	A	A	58030907	2	1	41	1	0	0	0	0	0	0	0	1	17904	1103	39	1		1	ZNF319	16	58030907	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	942186	58030907	32323846	130	8794											
DDX19A	55308	broad.mit.edu	37	chr16	70398481	70398481	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccagtctcagtctggcaCtggtaaaacagctgcctttg	8	11	10	12	0	2	0	1	0	2	0	3	0	2	0	2	2	4	3	2	2	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr16:70398481C>A	uc002eyv.2	+	6	493	c.422C>A	c.(421-423)ACT>AAT	p.T141N	DDX19B_uc010vly.1_Intron|DDX19A_uc002eys.2_Missense_Mutation_p.T142N|DDX19A_uc010cfq.1_Intron|DDX19A_uc010cfr.2_Translation_Start_Site|DDX19A_uc010cfs.2_Translation_Start_Site|DDX19A_uc010vlz.1_Missense_Mutation_p.T110N|DDX19A_uc010vma.1_Missense_Mutation_p.T51N	NM_018332	NP_060802	Q9NUU7	DD19A_HUMAN	DDX19-like protein	141	ATP (By similarity).|Helicase ATP-binding.				mRNA transport|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding				0		Ovarian(137;0.221)				CAGTCTGGCACTGGTAAAACA	0.498													3	81					0.00909568	0.00923144	1	0	A	70398481	A	A	70398481	3	1	41	1	0	0	0	0	1	0	0	0	4363	565	20	4	444	4	DDX19A	16	70398481	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	12367574	70398481	19956272	131	8795											
PHLPP2	23035	broad.mit.edu	37	chr16	71710374	71710374	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaactggcatagagggtccGaagggaaaagccactgagtg	13	5	16	7	1	0	2	0	1	0	1	1	5	1	4	2	4	2	1	2	4	5	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr16:71710374G>A	uc002fax.2	-	8	1453	c.1447C>T	c.(1447-1449)CGG>TGG	p.R483W	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Missense_Mutation_p.R483W	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	483	LRR 11.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						TAGAGGGTCCGAAGGGAAAAG	0.502													7	51					0	0	0	0	A	71710374	A	A	71710374	3	1	41	1	0	0	0	0	1	0	0	0	11910	1057	37	1	2568	1	PHLPP2	16	71710374	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	1311893	71710374	18644379	132	8796											
SMG6	23293	broad.mit.edu	37	chr17	2203496	2203496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttcctccttcgcaacatttCccctacactcatcttcctct	6	15	1	19	1	3	0	1	0	2	0	8	0	7	0	5	0	2	1	5	0	2	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:2203496C>T	uc002fub.1	-	2	606	c.551G>A	c.(550-552)GGA>GAA	p.G184E	SMG6_uc002fud.1_Missense_Mutation_p.G153E	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	184	Interaction with telomeric DNA.|Potential.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						CGCAACATTTCCCCTACACTC	0.502													131	582					0	0	0	0	T	2203496	T	T	2203496	3	4	41	1	0	0	0	0	1	0	0	0	14861	855	30	2	3780	2	SMG6	17	2203496	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08		2203496	78991714	133	8797											
OR1G1	8390	broad.mit.edu	37	chr17	3030782	3030782	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaagaggggcttctgctcctCcagctgctcagagaacccca	10	7	10	14	0	2	2	1	0	1	2	4	3	4	2	4	2	4	4	4	2	2	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:3030782C>T	uc002fvc.1	-	1	64	c.64G>A	c.(64-66)GAG>AAG	p.E22K		NM_003555	NP_003546	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCTGCTCCTCCAGCTGCTCA	0.493													12	112					0	0	0	0	T	3030782	T	T	3030782	3	4	41	1	0	0	0	0	1	0	0	0	11011	864	30	2	881	2	OR1G1	17	3030782	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	827286	3030782	78164428	134	8798											
SLC16A13	201232	broad.mit.edu	37	chr17	6939688	6939688	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctctgggtggcagcagccCtgttaccgcttagatggcgc	5	9	15	12	2	1	1	0	0	1	1	1	1	1	1	2	4	3	5	2	4	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:6939688C>A	uc002geh.2	+	1	295	c.-13C>A	c.(-15--11)CCCTG>CCATG			NM_201566	NP_963860	Q7RTY0	MOT13_HUMAN	monocarboxylate transporter 13							integral to membrane|plasma membrane	symporter activity			ovary(1)|skin(1)	2						GGCAGCAGCCCTGTTACCGCT	0.697													4	131					0.00116845	0.00120385	1	0	A	6939688	A	A	6939688	1	1	41	1	0	0	0	0	0	0	0	0	14471	696	24	4		4	SLC16A13	17	6939688	Translation_Start_Site	SNP	C	TCGA-CN-4729-01A-01D-1434-08	3908906	6939688	74255522	135	8799											
TP53	7157	broad.mit.edu	37	chr17	7578394	7578394	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctatctgagcagcgctcaTggtgggggcagcgcctcaca	7	7	14	13	3	3	1	2	1	1	0	3	1	3	1	1	3	3	4	1	3	1	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:7578394T>C	uc002gim.2	-	5	730	c.536A>G	c.(535-537)CAT>CGT	p.H179R	TP53_uc002gig.1_Missense_Mutation_p.H179R|TP53_uc002gih.2_Missense_Mutation_p.H179R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47R|TP53_uc010cng.1_Missense_Mutation_p.H47R|TP53_uc002gii.1_Missense_Mutation_p.H47R|TP53_uc010cnh.1_Missense_Mutation_p.H179R|TP53_uc010cni.1_Missense_Mutation_p.H179R|TP53_uc002gij.2_Missense_Mutation_p.H179R|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86R|TP53_uc002gio.2_Missense_Mutation_p.H47R|TP53_uc010vug.1_Missense_Mutation_p.H140R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	53					0	0	0	0	C	7578394	C	C	7578394	3	2	41	1	0	0	0	0	1	0	0	0	16448	1464	51	5	762	5	TP53	17	7578394	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	638706	7578394	73616816	136	8800											
TP53	7157	broad.mit.edu	37	chr17	7578461	7578461	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagatggccatggcgcggaCgcgggtgccgggcgggggtg	4	5	23	9	6	0	1	0	0	0	1	0	2	0	2	2	7	1	1	2	7	1	1	rs121912654		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:7578461C>A	uc002gim.2	-	5	663	c.469G>T	c.(469-471)GTC>TTC	p.V157F	TP53_uc002gig.1_Missense_Mutation_p.V157F|TP53_uc002gih.2_Missense_Mutation_p.V157F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V25F|TP53_uc010cng.1_Missense_Mutation_p.V25F|TP53_uc002gii.1_Missense_Mutation_p.V25F|TP53_uc010cnh.1_Missense_Mutation_p.V157F|TP53_uc010cni.1_Missense_Mutation_p.V157F|TP53_uc002gij.2_Missense_Mutation_p.V157F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V64F|TP53_uc002gio.2_Missense_Mutation_p.V25F|TP53_uc010vug.1_Missense_Mutation_p.V118F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	157	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> I (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> F (in sporadic cancers; somatic mutation).|V -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V157F(139)|p.V157I(10)|p.V157D(8)|p.V157G(7)|p.0?(7)|p.V157L(6)|p.V157V(5)|p.V157fs*13(3)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.V157fs*22(2)|p.V157fs*24(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.V157A(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.D148fs*23(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.V157fs*25(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCGCGGACGCGGGTGCCG	0.617		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	63					2.70639e-06	2.81686e-06	1	0	A	7578461	A	A	7578461	3	1	41	1	0	0	0	0	1	0	0	0	16448	536	19	3	829	3	TP53	17	7578461	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	67	7578461	73616749	137	8801											
WRAP53	55135	broad.mit.edu	37	chr17	7604804	7604804	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagcagccgggagaacccGattcatatctgggacgcatt	11	7	12	11	3	2	1	1	0	1	1	2	4	2	2	2	2	4	3	2	2	2	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:7604804G>T	uc010vuh.1	+	6	914	c.759G>T	c.(757-759)CCG>CCT	p.P253P	WRAP53_uc010vui.1_Silent_p.P253P|WRAP53_uc002gip.2_Silent_p.P253P|WRAP53_uc002gir.2_Silent_p.P253P|WRAP53_uc002giq.2_RNA|WRAP53_uc010cnl.2_Silent_p.P220P|WRAP53_uc010vuj.1_Silent_p.P34P	NM_001143990	NP_001137462	Q9BUR4	WAP53_HUMAN	WD repeat domain 79 isoform 2	253	WD 2.				positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding				0						GGGAGAACCCGATTCATATCT	0.537													40	119					3.4345e-17	3.93617e-17	1	0	T	7604804	T	T	7604804	2	4	41	1	0	0	0	0	0	0	0	1	17468	1045	37	3		3	WRAP53	17	7604804	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	26343	7604804	73590406	138	8802											
PER1	5187	broad.mit.edu	37	chr17	8049769	8049769	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggtggtataggaggaggaGgaggcacatttacgcttagt	11	9	17	4	1	0	0	0	0	0	0	0	5	0	4	0	7	1	3	0	7	4	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:8049769G>A	uc002gkd.2	-	16	2197	c.1959C>T	c.(1957-1959)TCC>TCT	p.S653S	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Silent_p.S637S	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	653	Poly-Ser.|CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						AGGAGGAGGAGGAGGCACATT	0.587			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					41	126					0	0	0	0	A	8049769	A	A	8049769	2	1	41	1	0	0	0	0	0	0	0	1	11783	987	35	4		4	PER1	17	8049769	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	444965	8049769	73145441	139	8803											
C17orf76	388341	broad.mit.edu	37	chr17	16347302	16347302	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgtcgtccgtgaggcctGtgaagcccagctccacgctg	6	8	12	15	3	0	2	0	2	0	0	3	2	2	2	5	1	2	2	5	1	1	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:16347302G>T	uc010cph.1	-	4	811	c.635C>A	c.(634-636)ACA>AAA	p.T212K	C17orf76_uc002gqh.2_Missense_Mutation_p.H173Q|NCRNA00188_uc010vwl.1_Intron|NCRNA00188_uc010vwm.1_Intron|NCRNA00188_uc010vwn.1_Intron|NCRNA00188_uc010cpe.2_Intron|NCRNA00188_uc010vwo.1_Intron|NCRNA00188_uc010vwp.1_Intron|C17orf76_uc002gqg.1_3'UTR	NM_001113567	NP_001107039	Q8NAA5	CQ076_HUMAN	hypothetical protein LOC388341 isoform 1	212	LRR 1.										0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		CGTGAGGCCTGTGAAGCCCAG	0.657													18	55					5.01169e-05	5.18977e-05	1	0	T	16347302	T	T	16347302	3	4	41	1	0	0	0	0	1	0	0	0	1889	1377	48	4	403	4	C17orf76	17	16347302	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	8297533	16347302	64847908	140	8804											
KRTAP4-5	85289	broad.mit.edu	37	chr17	39305733	39305733	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acacacagcagctggggcagCagcaggtggtcctgcagcag	10	4	15	12	0	0	0	0	0	0	0	1	0	1	0	1	4	6	7	1	4	0	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:39305733C>A	uc002hwb.2	-	1	322	c.287G>T	c.(286-288)TGC>TTC	p.C96F		NM_033188	NP_149445	Q9BYR2	KRA45_HUMAN	keratin associated protein 4-5	101	27 X 5 AA repeats of C-C-[GRQVCHIEK]- [SPTR]-[VSTQYC].|17.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			gctggggcagcagcaggtggt	0.124													14	39					2.35188e-11	2.57948e-11	1	0	A	39305733	A	A	39305733	3	1	41	1	0	0	0	0	1	0	0	0	8594	710	25	4	262	4	KRTAP4-5	17	39305733	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	22958431	39305733	41889477	141	8805											
SLC4A1	6521	broad.mit.edu	37	chr17	42335957	42335957	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gggagtgcagcagctcccctCggctctgagccatgtaggca	7	7	14	13	1	1	1	0	1	1	0	3	2	2	2	3	3	4	6	3	3	1	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:42335957C>G	uc002igf.3	-	10	1060	c.911G>C	c.(910-912)CGA>CCA	p.R304P	SLC4A1_uc002igg.3_Missense_Mutation_p.R304P	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	304	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		CAGCTCCCCTCGGCTCTGAGC	0.647													5	27					0	0	0	0	G	42335957	G	G	42335957	3	3	41	1	0	0	0	0	1	0	0	0	14714	884	31	3	1868	3	SLC4A1	17	42335957	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	3030224	42335957	38859253	142	8806											
RNF213	57674	broad.mit.edu	37	chr17	78321813	78321813	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctaccactcggacgcctgCgcgtctgtggtgctgcaggt	4	9	15	13	4	1	0	0	0	1	0	2	1	1	1	2	4	4	3	2	4	1	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr17:78321813C>T	uc002jyh.1	+	4	4120	c.3897C>T	c.(3895-3897)TGC>TGT	p.C1299C		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CGGACGCCTGCGCGTCTGTGG	0.562													6	30					0	0	0	0	T	78321813	T	T	78321813	2	4	41	1	0	0	0	0	0	0	0	1	13542	776	27	1		1	RNF213	17	78321813	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	35985856	78321813	2873397	143	8807											
ROCK1	6093	broad.mit.edu	37	chr18	18534783	18534783	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctctttcttatctaagtGatctctgtggcacttaacat	8	17	6	10	0	4	1	0	1	4	0	6	1	5	1	1	1	1	1	1	1	3	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr18:18534783G>T	uc002kte.2	-	31	4755	c.3814C>A	c.(3814-3816)CAC>AAC	p.H1272N		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1272	PH.|Auto-inhibitory.|Phorbol-ester/DAG-type.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TTATCTAAGTGATCTCTGTGG	0.393													11	195					1.15088e-07	1.2102e-07	1	0	T	18534783	T	T	18534783	3	4	41	1	0	0	0	0	1	0	0	0	13582	1290	45	2	262	2	ROCK1	18	18534783	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08		18534783	59542465	144	8808											
CCDC102B	79839	broad.mit.edu	37	chr18	66541993	66541993	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaatctcaaaacagcaaaGacagagtgatttgtgagtta	17	9	8	7	0	1	4	1	2	1	2	2	4	1	4	1	0	2	2	1	0	5	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr18:66541993G>A	uc002lkk.2	+	7	1247	c.1024G>A	c.(1024-1026)GAC>AAC	p.D342N	CCDC102B_uc002lki.2_Missense_Mutation_p.D342N|CCDC102B_uc002lkj.1_Missense_Mutation_p.D342N	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	342										ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AAACAGCAAAGACAGAGTGAT	0.333													9	87					0	0	0	0	A	66541993	A	A	66541993	3	1	41	1	0	0	0	0	1	0	0	0	2749	942	33	2	1038	2	CCDC102B	18	66541993	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	48007210	66541993	11535255	145	8809											
CCDC102B	79839	broad.mit.edu	37	chr18	66564499	66564499	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacctcggagtgggacaagaGggaaatacttgaaagagaaa	17	6	13	5	1	0	3	0	1	0	2	1	7	0	6	1	3	2	0	1	3	6	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr18:66564499G>T	uc002lkk.2	+	8	1320	c.1097G>T	c.(1096-1098)AGG>ATG	p.R366M	CCDC102B_uc002lki.2_Missense_Mutation_p.R366M|CCDC102B_uc002lkj.1_Missense_Mutation_p.R366M	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	366	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				TGGGACAAGAGGGAAATACTT	0.403													24	105					1.66031e-10	1.79208e-10	1	0	T	66564499	T	T	66564499	3	4	41	1	0	0	0	0	1	0	0	0	2749	1000	35	4	1115	4	CCDC102B	18	66564499	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	22506	66564499	11512749	146	8810											
TSHZ1	10194	broad.mit.edu	37	chr18	72999255	72999255	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggagcctcacgcccccaccGcacaagagcaacgtgtctgc	9	4	11	17	3	2	1	1	0	1	1	2	2	2	2	4	1	4	2	4	1	2	0	rs145239521		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr18:72999255G>A	uc002lly.2	+	2	2321	c.1758G>A	c.(1756-1758)CCG>CCA	p.P586P		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	631						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CGCCCCCACCGCACAAGAGCA	0.632													3	60					0	0	0	0	A	72999255	A	A	72999255	2	1	41	1	0	0	0	0	0	0	0	1	16690	1074	38	1		1	TSHZ1	18	72999255	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	6434756	72999255	5077993	147	8811											
ISYNA1	51477	broad.mit.edu	37	chr19	18546863	18546863	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgaggccggagccaatgagGaagtccacaagcacggactt	12	6	13	10	2	0	2	0	2	0	0	1	5	1	5	3	4	2	1	3	4	3	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:18546863G>T	uc002njd.1	-	7	1004	c.954C>A	c.(952-954)TTC>TTA	p.F318L	ISYNA1_uc002nja.1_Missense_Mutation_p.F190L|ISYNA1_uc002njb.1_Missense_Mutation_p.F236L|ISYNA1_uc002njc.1_Missense_Mutation_p.F168L|ISYNA1_uc010xqh.1_Missense_Mutation_p.F116L|ISYNA1_uc002nje.1_Missense_Mutation_p.F264L|ISYNA1_uc002njf.1_Missense_Mutation_p.F168L	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	318					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2						AGCCAATGAGGAAGTCCACAA	0.652													12	35					7.03913e-09	7.47907e-09	1	0	T	18546863	T	T	18546863	3	4	41	1	0	0	0	0	1	0	0	0	7906	1165	41	2	742	2	ISYNA1	19	18546863	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08		18546863	40582120	148	8812											
ZNF708	7562	broad.mit.edu	37	chr19	21476477	21476477	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttagtaaggattgagaataTactaaaggctttaccacatt	15	14	7	5	0	0	1	0	1	0	1	0	3	0	2	1	2	2	2	1	2	8	10	rs149009596		TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:21476477T>C	uc002npq.1	-	4	1489	c.1291A>G	c.(1291-1293)ATA>GTA	p.I431V	ZNF708_uc002npr.1_Missense_Mutation_p.I367V|ZNF708_uc010ecs.1_Missense_Mutation_p.I367V	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	431	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						ATTGAGAATATACTAAAGGCT	0.328													20	70					0	0	0	0	C	21476477	C	C	21476477	3	2	41	1	0	0	0	0	1	0	0	0	18179	1406	49	5	404	5	ZNF708	19	21476477	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	2929614	21476477	37652506	149	8813											
ZBTB32	27033	broad.mit.edu	37	chr19	36207617	36207617	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgaggccgtctcggccctCgacctctccctgttgtcctt	2	12	9	18	4	2	0	0	0	2	0	7	2	3	0	5	2	0	1	5	2	0	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:36207617C>T	uc002oay.2	+	6	1637	c.1427C>T	c.(1426-1428)TCG>TTG	p.S476L	ZBTB32_uc002oaz.2_RNA|MLL4_uc010eei.2_5'Flank	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	476					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCTCGGCCCTCGACCTCTCCC	0.632											OREG0025433	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	158					0	0	0	0	T	36207617	T	T	36207617	3	4	41	1	0	0	0	0	1	0	0	0	17602	893	31	1	1445	1	ZBTB32	19	36207617	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	14731140	36207617	22921366	150	8814											
ZFP82	284406	broad.mit.edu	37	chr19	36883703	36883703	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaatgttgcctaaaggcCttcttacattccttacattc	9	16	6	10	0	1	1	0	1	1	0	3	1	2	1	3	1	3	1	3	1	5	7			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:36883703C>T	uc002ody.1	-	5	1774	c.1539G>A	c.(1537-1539)AAG>AAA	p.K513K		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	513	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						GCCTAAAGGCCTTCTTACATT	0.338													19	79					0	0	0	0	T	36883703	T	T	36883703	2	4	41	1	0	0	0	0	0	0	0	1	17720	680	24	4		4	ZFP82	19	36883703	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	676086	36883703	22245280	151	8815											
HKR1	284459	broad.mit.edu	37	chr19	37853704	37853704	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgtgcaaggattgtggacGaggctttacttggaagtcga	9	12	15	5	2	0	0	0	0	0	0	1	5	0	3	0	4	2	2	0	4	3	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:37853704G>A	uc002ogb.2	+	6	1276	c.1007G>A	c.(1006-1008)CGA>CAA	p.R336Q	HKR1_uc002ofx.2_Missense_Mutation_p.R52Q|HKR1_uc002ofy.2_Missense_Mutation_p.R52Q|HKR1_uc002oga.2_Missense_Mutation_p.R318Q|HKR1_uc010xto.1_Missense_Mutation_p.R318Q|HKR1_uc002ogc.2_Missense_Mutation_p.R317Q|HKR1_uc010xtp.1_Missense_Mutation_p.R275Q|HKR1_uc002ogd.2_Missense_Mutation_p.R275Q	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	336	C2H2-type 2.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GATTGTGGACGAGGCTTTACT	0.507													14	118					0	0	0	0	A	37853704	A	A	37853704	3	1	41	1	0	0	0	0	1	0	0	0	7233	1058	37	1	1021	1	HKR1	19	37853704	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	970001	37853704	21275279	152	8816											
HNRNPL	3191	broad.mit.edu	37	chr19	39340525	39340525	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcaccatcgctcccgaccGcctccgctgctcgtccggct	3	9	8	21	6	1	0	1	0	0	0	6	1	4	0	6	1	1	4	6	1	0	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:39340525G>C	uc010xul.1	-	1	93	c.82C>G	c.(82-84)CGG>GGG	p.R28G	HNRNPL_uc010xum.1_Intron	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	28					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			GCTCCCGACCGCCTCCGCTGC	0.512													3	1					0	0	0	0	C	39340525	C	C	39340525	3	2	41	1	0	0	0	0	1	0	0	0	7309	1086	38	3	1739	3	HNRNPL	19	39340525	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	1486821	39340525	19788458	153	8817											
FCGBP	8857	broad.mit.edu	37	chr19	40357679	40357679	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacacggcctggtgggcagcCagctgcctggcatgtcaggc	6	7	15	13	1	1	0	1	0	0	0	1	0	1	0	3	5	4	3	3	5	1	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:40357679C>G	uc002omp.3	-	34	15642	c.15634G>C	c.(15634-15636)GGC>CGC	p.G5212R		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5212	Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGTGGGCAGCCAGCTGCCTGG	0.622													19	72					0	0	0	0	G	40357679	G	G	40357679	3	3	41	1	0	0	0	0	1	0	0	0	5810	594	21	4	595	4	FCGBP	19	40357679	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	1017154	40357679	18771304	154	8818											
GIPR	2696	broad.mit.edu	37	chr19	46185005	46185005	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgcagtcggagatccgcCgtggctggcaccactgccgc	6	6	15	14	4	0	1	0	0	0	1	2	2	1	1	4	4	2	3	4	4	0	0			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:46185005C>G	uc002pcu.1	+	14	1312	c.1213C>G	c.(1213-1215)CGT>GGT	p.R405G	GIPR_uc002pct.1_3'UTR|GIPR_uc010xxp.1_Missense_Mutation_p.R369G|GIPR_uc010xxq.1_RNA	NM_000164	NP_000155	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	405	Cytoplasmic (Potential).				generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		GGAGATCCGCCGTGGCTGGCA	0.776													7	7					0	0	0	0	G	46185005	G	G	46185005	3	3	41	1	0	0	0	0	1	0	0	0	6432	652	23	3	1263	3	GIPR	19	46185005	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	5827326	46185005	12943978	155	8819											
DMPK	1760	broad.mit.edu	37	chr19	46281829	46281829	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaagcgcgccatctcggccGgaatccgctccccaaacttg	9	6	10	16	5	1	1	0	0	1	1	4	2	3	2	5	2	2	1	5	2	3	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:46281829G>A	uc002pdd.1	-	4	1077	c.533C>T	c.(532-534)CCG>CTG	p.P178L	DMPK_uc010xxs.1_Missense_Mutation_p.P79L|DMPK_uc002pde.1_Missense_Mutation_p.P178L|DMPK_uc002pdf.1_Missense_Mutation_p.P168L|DMPK_uc002pdg.1_Missense_Mutation_p.P168L|DMPK_uc002pdh.1_Missense_Mutation_p.P168L|DMPK_uc002pdi.1_Missense_Mutation_p.P194L|DMPK_uc010xxt.1_Missense_Mutation_p.P168L|DMPK_uc010xxu.1_3'UTR	NM_001081563	NP_001075032	Q09013	DMPK_HUMAN	myotonic dystrophy protein kinase isoform 1	178	Protein kinase.				regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)	3		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		CATCTCGGCCGGAATCCGCTC	0.612													3	66					0	0	0	0	A	46281829	A	A	46281829	3	1	41	1	0	0	0	0	1	0	0	0	4606	1116	39	1	1437	1	DMPK	19	46281829	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	96824	46281829	12847154	156	8820											
ZNF264	9422	broad.mit.edu	37	chr19	57724189	57724189	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaacagatgtgggaagacCttttacaagtggacaaacct	14	10	10	7	0	0	2	0	0	0	2	0	4	0	4	2	2	3	1	2	2	5	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:57724189C>A	uc002qob.2	+	4	2137	c.1724C>A	c.(1723-1725)CCT>CAT	p.P575H		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		GTGGGAAGACCTTTTACAAGT	0.443													32	129					1.62565e-12	1.8122e-12	1	0	A	57724189	A	A	57724189	3	1	41	1	0	0	0	0	1	0	0	0	17871	681	24	4	1738	4	ZNF264	19	57724189	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	11442360	57724189	1404794	157	8821											
ZNF547	284306	broad.mit.edu	37	chr19	57889289	57889289	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctacactcagtagacatcaGagagttcacactggagaaag	15	8	9	9	0	4	3	3	0	1	3	4	5	4	3	0	1	1	2	0	1	3	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:57889289G>C	uc002qol.2	+	4	1138	c.945G>C	c.(943-945)CAG>CAC	p.Q315H	ZNF547_uc002qpm.3_Missense_Mutation_p.Q241H|ZNF547_uc010ygx.1_Missense_Mutation_p.Q315H	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	315	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTAGACATCAGAGAGTTCACA	0.413													17	142					0	0	0	0	C	57889289	C	C	57889289	3	2	41	1	0	0	0	0	1	0	0	0	18046	933	33	2	955	2	ZNF547	19	57889289	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	165100	57889289	1239694	158	8822											
ZNF544	27300	broad.mit.edu	37	chr19	58772562	58772562	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttaaagagttgaaacaaaAttcagctttcattaatcatg	17	13	6	5	0	3	2	3	1	0	1	3	2	3	2	0	0	2	3	0	0	6	5			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr19:58772562A>G	uc010euo.2	+	7	1064	c.590A>G	c.(589-591)AAT>AGT	p.N197S	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.N169S|ZNF544_uc010yhy.1_Missense_Mutation_p.N169S|ZNF544_uc002qrt.3_Missense_Mutation_p.N55S|ZNF544_uc002qru.3_Missense_Mutation_p.N55S|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TTGAAACAAAATTCAGCTTTC	0.383													17	88					0	0	0	0	G	58772562	G	G	58772562	3	3	41	1	0	0	0	0	1	0	0	0	18044	101	4	5	604	5	ZNF544	19	58772562	Missense_Mutation	SNP	A	TCGA-CN-4729-01A-01D-1434-08	883273	58772562	356421	159	8823											
RBCK1	10616	broad.mit.edu	37	chr20	398254	398254	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatgacagtggcgtctctCaaggacatggtgagtgagga	11	9	15	6	1	2	3	1	3	1	0	3	6	2	5	0	4	0	0	0	4	2	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr20:398254C>G	uc002wdp.3	+	3	945	c.252C>G	c.(250-252)CTC>CTG	p.L84L	RBCK1_uc010zpl.1_Silent_p.L84L|RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Silent_p.L42L|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_5'UTR	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	84	Interaction with IRF3.|Ubiquitin-like.|Interaction with RNF31.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				TGGCGTCTCTCAAGGACATGG	0.443													4	73					0	0	0	0	G	398254	G	G	398254	2	3	41	1	0	0	0	0	0	0	0	1	13172	813	29	2		2	RBCK1	20	398254	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08		398254	62627266	160	8824											
RNF160	26046	broad.mit.edu	37	chr21	30339459	30339459	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttaaatagctgcccatgttGcaatcctgggtctttgagaa	10	13	10	8	0	1	1	0	1	1	1	2	2	2	1	2	1	3	4	2	1	5	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr21:30339459G>T	uc002ymr.2	-	10	1505	c.1492C>A	c.(1492-1494)CAA>AAA	p.Q498K	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	452							ligase activity|zinc ion binding				0						TGCCCATGTTGCAATCCTGGG	0.323													23	93					2.32416e-17	2.67869e-17	1	0	T	30339459	T	T	30339459	3	4	41	1	0	0	0	0	1	0	0	0	13520	1328	46	4	4030	4	RNF160	21	30339459	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08		30339459	17790436	161	8825											
GCFC1	94104	broad.mit.edu	37	chr21	34123488	34123488	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttgatacagtgcccgatCgcgtccaaaggagtcaagat	11	9	10	11	3	2	2	1	1	1	1	4	4	3	3	2	1	2	0	2	1	3	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr21:34123488C>A	uc002yqn.2	-	9	1739	c.1549G>T	c.(1549-1551)GAT>TAT	p.D517Y	GCFC1_uc002yql.2_Missense_Mutation_p.D26Y|GCFC1_uc002yqm.2_Missense_Mutation_p.D11Y|GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Missense_Mutation_p.D517Y	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	517						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						AGTGCCCGATCGCGTCCAAAG	0.463													35	113					3.76114e-14	4.23907e-14	1	0	A	34123488	A	A	34123488	3	1	41	1	0	0	0	0	1	0	0	0	6324	884	31	3	1362	3	GCFC1	21	34123488	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	3784029	34123488	14006407	162	8826											
PRDM15	63977	broad.mit.edu	37	chr21	43221744	43221745	+	Frame_Shift_Ins	INS	-	A	A																															aactggcgttcaggggtggtINSaaggtgccccacggccaccg																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr21:43221744_43221745insA	uc002yzq.1	-	31	4290_4291	c.4179_4180insT	c.(4177-4182)CTTACCfs	p.L1393fs	PRDM15_uc002yzo.2_Frame_Shift_Ins_p.L1064fs|PRDM15_uc002yzp.2_Frame_Shift_Ins_p.L1084fs|PRDM15_uc002yzr.1_Frame_Shift_Ins_p.L1084fs	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1393_1394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCAGGGGTGGTAAGGTGCCCCA	0.579													---	---	---								A	43221745	A	A	43221744	7	5	41	1	0	1	1	0	0	0	0	0	12518	1638	57	0	347	0	PRDM15	21	43221744	Frame_Shift_Ins	INS	-	TCGA-CN-4729-01A-01D-1434-08	9098256	43221744	4908151	163	8827											
ZDHHC8	29801	broad.mit.edu	37	chr22	20127356	20127356	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atggtgggcgtcgtggccttCggcctggtctacgtgctgaa	4	11	16	10	4	1	1	0	1	1	0	3	1	1	1	2	5	2	1	2	5	2	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:20127356C>T	uc002zrq.2	+	4	604	c.498C>T	c.(496-498)TTC>TTT	p.F166F	ZDHHC8_uc002zrr.1_Silent_p.F166F|ZDHHC8_uc010gsa.2_Intron	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	166	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					TCGTGGCCTTCGGCCTGGTCT	0.602													10	67					0	0	0	0	T	20127356	T	T	20127356	2	4	41	1	0	0	0	0	0	0	0	1	17688	883	31	1		1	ZDHHC8	22	20127356	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08		20127356	31177210	164	8828											
SMARCB1	6598	broad.mit.edu	37	chr22	24135759	24135759	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttacagatcacggatacacGactctagccaccagtgtgac	12	8	9	12	2	2	2	1	1	1	1	2	4	2	3	2	1	3	1	2	1	3	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:24135759G>T	uc002zyb.2	+	3	453	c.246G>T	c.(244-246)ACG>ACT	p.T82T	SMARCB1_uc002zyg.2_Silent_p.T82T|SMARCB1_uc011ajb.1_Silent_p.T73T|SMARCB1_uc002zya.2_Silent_p.T82T|SMARCB1_uc002zyc.2_Silent_p.T73T|SMARCB1_uc002zyd.2_Silent_p.T73T|SMARCB1_uc002zye.1_Silent_p.T45T|SMARCB1_uc002zyf.1_RNA|SMARCB1_uc010gue.1_Intron	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	82					cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(2)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				ACGGATACACGACTCTAGCCA	0.532			D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				53	179					1.46156e-29	1.71355e-29	1	0	T	24135759	T	T	24135759	2	4	41	1	0	0	0	0	0	0	0	1	14838	1045	37	3		3	SMARCB1	22	24135759	Silent	SNP	G	TCGA-CN-4729-01A-01D-1434-08	4008403	24135759	27168807	165	8829											
CRYBA4	1413	broad.mit.edu	37	chr22	27024279	27024279	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgactcgaggctgacaatcTtcgagcaagagaacttcctg	11	9	11	10	2	1	3	0	2	1	1	4	6	2	3	1	1	2	2	1	1	3	2			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:27024279T>A	uc003acz.3	+	5	363	c.328T>A	c.(328-330)TTC>ATC	p.F110I		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	110	Beta/gamma crystallin 'Greek key' 3.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						GCTGACAATCTTCGAGCAAGA	0.562													4	85					0	0	0	0	A	27024279	A	A	27024279	3	1	41	1	0	0	0	0	1	0	0	0	3924	1609	56	5	342	5	CRYBA4	22	27024279	Missense_Mutation	SNP	T	TCGA-CN-4729-01A-01D-1434-08	2888520	27024279	24280287	166	8830											
APOL4	80832	broad.mit.edu	37	chr22	36595382	36595392	+	Frame_Shift_Del	DEL	ACTGTCCAGCC	-	-																															tctgaaaggcttaccttggaActgtccagccactgtccagc																										TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:36595382_36595392delACTGTCCAGCC	uc003aox.2	-	3	300_310	c.75_85delGGCTGGACAGT	c.(73-87)GTGGCTGGACAGTTCfs	p.V25fs	APOL4_uc003aow.2_Frame_Shift_Del_p.V22fs|APOL4_uc010gww.2_5'UTR|APOL4_uc003aoy.2_RNA	NM_145660	NP_663693	Q9BPW4	APOL4_HUMAN	apolipoprotein L4 isoform 2 precursor	25_29					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding				0						TTACCTTGGAACTGTCCAGCCACTGTCCAGC	0.54													---	---	---								-	36595392	-	-	36595382	7	5	41	1	0	1	0	1	0	0	0	0	808	43	2	0	980	0	APOL4	22	36595382	Frame_Shift_Del	DEL	ACTGTCCAGCC	TCGA-CN-4729-01A-01D-1434-08	9571103	36595382	14709184	167	8831											
ELFN2	114794	broad.mit.edu	37	chr22	37770534	37770534	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcgcccgcagtttgtccagCgtcacgatctccttcttgtt	4	14	9	14	4	3	0	1	0	2	0	5	1	4	0	3	0	2	3	3	0	0	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:37770534C>T	uc003asq.3	-	3	1827	c.1041G>A	c.(1039-1041)ACG>ACA	p.T347T		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	347	Fibronectin type-III.|Extracellular (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					GTTTGTCCAGCGTCACGATCT	0.572													53	141					0	0	0	0	T	37770534	T	T	37770534	2	4	41	1	0	0	0	0	0	0	0	1	5082	755	27	1		1	ELFN2	22	37770534	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	1175152	37770534	13534032	168	8832											
L3MBTL2	83746	broad.mit.edu	37	chr22	41623203	41623203	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgagtggtgcatcggctcctCagcatccactttgacggctg	6	10	12	13	3	1	1	1	1	0	0	4	2	3	1	2	3	2	4	2	3	0	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chr22:41623203C>T	uc003azo.2	+	14	1752	c.1698C>T	c.(1696-1698)CTC>CTT	p.L566L	L3MBTL2_uc010gyi.1_Silent_p.L475L|L3MBTL2_uc003azn.2_RNA	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	566	MBT 4.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						ATCGGCTCCTCAGCATCCACT	0.627													3	28					0	0	0	0	T	41623203	T	T	41623203	2	4	41	1	0	0	0	0	0	0	0	1	8632	813	29	2		2	L3MBTL2	22	41623203	Silent	SNP	C	TCGA-CN-4729-01A-01D-1434-08	3852669	41623203	9681363	169	8833											
BEND2	139105	broad.mit.edu	37	chrX	18234753	18234753	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acataagtggaatcatctgcTatgtcattagtggaattatc	13	14	8	6	0	3	0	2	0	1	0	4	2	3	2	0	2	1	1	0	2	6	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chrX:18234753T>A	uc004cyj.3	-	2	280	c.126A>T	c.(124-126)ATA>ATT	p.I42I	BEND2_uc010nfb.2_Silent_p.I42I	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	42										ovary(3)|kidney(1)|central_nervous_system(1)	5						AATCATCTGCTATGTCATTAG	0.418													26	33					0	0	0	0	A	18234753	A	A	18234753	2	1	41	1	0	0	0	0	0	0	0	1	1400	1512	53	5		5	BEND2	23	18234753	Silent	SNP	T	TCGA-CN-4729-01A-01D-1434-08		18234753	137035807	170	8834											
DMD	1756	broad.mit.edu	37	chrX	32482777	32482777	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctccttcagaaaaacatCaacttcagccatccatttct	12	13	2	14	0	4	1	3	0	1	1	7	1	7	1	4	0	3	0	4	0	3	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chrX:32482777C>T	uc004dda.1	-	24	3446	c.3202G>A	c.(3202-3204)GAT>AAT	p.D1068N	DMD_uc004dcz.2_Missense_Mutation_p.D945N|DMD_uc004dcy.1_Missense_Mutation_p.D1064N|DMD_uc004ddb.1_Missense_Mutation_p.D1060N|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1068	Spectrin 7.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGAAAAACATCAACTTCAGCC	0.388													12	84					0	0	0	0	T	32482777	T	T	32482777	3	4	41	1	0	0	0	0	1	0	0	0	4602	826	29	2	8322	2	DMD	23	32482777	Missense_Mutation	SNP	C	TCGA-CN-4729-01A-01D-1434-08	14248024	32482777	122787783	171	8835											
TFE3	7030	broad.mit.edu	37	chrX	48888064	48888064	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggccaaggaaagcagccctgGagtgggaggtactggcaggc	10	4	18	9	0	0	0	0	0	0	0	0	3	0	3	2	7	3	3	2	7	3	1			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chrX:48888064G>C	uc004dmb.3	-	10	1571	c.1333C>G	c.(1333-1335)CCA>GCA	p.P445A	TFE3_uc004dmc.3_Missense_Mutation_p.P340A	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	445					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						AGCAGCCCTGGAGTGGGAGGT	0.577			T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								13	29					0	0	0	0	C	48888064	C	C	48888064	3	2	41	1	0	0	0	0	1	0	0	0	15866	1174	41	2	398	2	TFE3	23	48888064	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	16405287	48888064	106382496	172	8836											
TFE3	7030	broad.mit.edu	37	chrX	48888088	48888088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggaggtactggcaggccatGgatctgggcctgcagttcta	7	9	16	9	0	2	0	0	0	2	0	2	2	2	2	2	6	2	4	2	6	2	3			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chrX:48888088G>A	uc004dmb.3	-	10	1547	c.1309C>T	c.(1309-1311)CAT>TAT	p.H437Y	TFE3_uc004dmc.3_Missense_Mutation_p.H332Y	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	437					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						GGCAGGCCATGGATCTGGGCC	0.547			T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								10	32					0	0	0	0	A	48888088	A	A	48888088	3	1	41	1	0	0	0	0	1	0	0	0	15866	1348	47	4	422	4	TFE3	23	48888088	Missense_Mutation	SNP	G	TCGA-CN-4729-01A-01D-1434-08	24	48888088	106382472	173	8837											
HDX	139324	broad.mit.edu	37	chrX	83723928	83723928	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggtaatcgctaactgccAatgaaaacacttcacggatt	13	9	10	9	2	1	1	1	1	0	0	2	2	1	2	1	3	3	2	1	3	5	4			TCGA-CN-4729-01A-01D-1434-08	TCGA-CN-4729-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	7240e742-9315-4fb8-b6f7-28bfe69410a8	de75d4f6-43b1-473c-9bf3-10a178cc9aa7	g.chrX:83723928A>G	uc004eek.1	-	3	912	c.803T>C	c.(802-804)TTG>TCG	p.L268S	HDX_uc011mqv.1_Missense_Mutation_p.L268S|HDX_uc004eel.1_Missense_Mutation_p.L210S	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	268						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCTAACTGCCAATGAAAACAC	0.453													51	74					0	0	0	0	G	83723928	G	G	83723928	3	3	41	1	0	0	0	0	1	0	0	0	7065	131	5	5	1301	5	HDX	23	83723928	Missense_Mutation	SNP	A	TCGA-CN-4729-01A-01D-1434-08	34835840	83723928	71546632	174	8838											
SYF2	25949	broad.mit.edu	37	chr1	25549911	25549911	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctccggctatatttgtctCgtttttcaatcctggggaaa	7	16	9	9	2	3	0	1	0	2	0	6	1	4	1	2	3	0	2	2	3	4	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:25549911C>T	uc001bjt.1	-	7	633	c.578G>A	c.(577-579)CGA>CAA	p.R193Q	SYF2_uc001bju.1_Missense_Mutation_p.R151Q	NM_015484	NP_056299	O95926	SYF2_HUMAN	SYF2 homolog, RNA splicing factor isoform 1	193						catalytic step 2 spliceosome					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)		ATATTTGTCTCGTTTTTCAAT	0.323													64	178					0	0	0	0	T	25549911	T	T	25549911	3	4	42	1	0	0	0	0	1	0	0	0	15503	884	31	1	157	1	SYF2	1	25549911	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08		25549911	223700710	1	8839											
EXTL1	2134	broad.mit.edu	37	chr1	26349620	26349620	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggggcaggaaccatctggtCctccgtctccacccggctcc	6	7	11	17	2	2	0	0	0	2	0	6	1	5	1	6	5	1	2	6	5	1	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:26349620C>T	uc001blf.2	+	1	1350	c.483C>T	c.(481-483)GTC>GTT	p.V161V		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	161	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		ACCATCTGGTCCTCCGTCTCC	0.667													30	69					0	0	0	0	T	26349620	T	T	26349620	2	4	42	1	0	0	0	0	0	0	0	1	5350	842	30	2		2	EXTL1	1	26349620	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	799709	26349620	222901001	2	8840											
DNAJC8	22826	broad.mit.edu	37	chr1	28536520	28536520	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttcctgcctgaattacaTccagggccctcttcttttgc	5	16	6	14	0	2	1	0	1	2	0	4	1	4	1	4	1	3	0	4	1	2	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:28536520T>A	uc001bpn.2	-	5	395	c.362A>T	c.(361-363)GAT>GTT	p.D121V	DNAJC8_uc001bpo.2_RNA	NM_014280	NP_055095	O75937	DNJC8_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 8	121	J.				nuclear mRNA splicing, via spliceosome|protein folding	nucleoplasm	heat shock protein binding|unfolded protein binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.08e-05)|all_lung(284;4.29e-05)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.0105)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		OV - Ovarian serous cystadenocarcinoma(117;2.81e-22)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00275)|BRCA - Breast invasive adenocarcinoma(304;0.0059)|STAD - Stomach adenocarcinoma(196;0.00671)|READ - Rectum adenocarcinoma(331;0.0649)		CTGAATTACATCCAGGGCCCT	0.428													22	106					0	0	0	0	A	28536520	A	A	28536520	3	1	42	1	0	0	0	0	1	0	0	0	4677	1435	50	5	419	5	DNAJC8	1	28536520	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08	2186900	28536520	220714101	3	8841											
RIMS3	9783	broad.mit.edu	37	chr1	41107474	41107474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctccgccgcttcttggCggtggtggtcccagccccgc	1	9	14	17	4	1	0	0	0	1	0	3	0	3	0	5	4	2	3	5	4	0	2	rs149583022		TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:41107474C>T	uc001cfu.1	-	3	593	c.124G>A	c.(124-126)GCC>ACC	p.A42T	RIMS3_uc001cfv.1_Missense_Mutation_p.A42T	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	42					neurotransmitter transport	cell junction|synapse					0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			CGCTTCTTGGCGGTGGTGGTC	0.657													17	62					0	0	0	0	T	41107474	T	T	41107474	3	4	42	1	0	0	0	0	1	0	0	0	13434	768	27	1	826	1	RIMS3	1	41107474	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	12570954	41107474	208143147	4	8842											
FOXD3	27022	broad.mit.edu	37	chr1	63789386	63789386	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aactactggaccctggacccGcagtccgaggacatgttcga	10	7	11	13	3	0	0	0	0	0	0	2	5	1	3	3	3	2	2	3	3	2	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:63789386G>A	uc001dax.2	+	1	657	c.657G>A	c.(655-657)CCG>CCA	p.P219P		NM_012183	NP_036315	Q9UJU5	FOXD3_HUMAN	forkhead box D3	219	Fork-head.				axon extension involved in axon guidance|branching involved in ureteric bud morphogenesis|cartilage development|embryonic placenta development|enteric nervous system development|iridophore differentiation|kidney development|lateral line nerve glial cell development|melanocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development|trophectodermal cell differentiation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CCCTGGACCCGCAGTCCGAGG	0.642													5	186					0	0	0	0	A	63789386	A	A	63789386	2	1	42	1	0	0	0	0	0	0	0	1	6030	1074	38	1		1	FOXD3	1	63789386	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	22681912	63789386	185461235	5	8843											
C1orf173	127254	broad.mit.edu	37	chr1	75037806	75037806	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctattctccctgctggaCagctcttctctgtctttgtg	3	16	8	14	0	4	0	0	0	4	0	6	1	4	1	2	1	2	2	2	1	1	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:75037806C>T	uc001dgg.2	-	14	3807	c.3588G>A	c.(3586-3588)CTG>CTA	p.L1196L		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1196	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCCTGCTGGACAGCTCTTCTC	0.552													129	198					0	0	0	0	T	75037806	T	T	75037806	2	4	42	1	0	0	0	0	0	0	0	1	2023	465	17	4		4	C1orf173	1	75037806	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	11248420	75037806	174212815	6	8844											
COL24A1	255631	broad.mit.edu	37	chr1	86499564	86499564	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtactcacaggactgccatCaagaccagcagggcctctgt	10	8	10	13	0	3	1	2	0	1	1	3	2	3	2	3	2	3	2	3	2	2	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:86499564C>A	uc001dlj.2	-	13	2035	c.1993G>T	c.(1993-1995)GAT>TAT	p.D665Y	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	665	Collagen-like 3.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GGACTGCCATCAAGACCAGCA	0.403													9	35					4.68919e-08	4.93491e-08	1	0	A	86499564	A	A	86499564	3	1	42	1	0	0	0	0	1	0	0	0	3698	826	29	2	3343	2	COL24A1	1	86499564	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	11461758	86499564	162751057	7	8845											
CCDC18	343099	broad.mit.edu	37	chr1	93649684	93649684	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtagcagcactgattttcAaaaaaagccaagagataagg	17	8	10	6	0	1	2	1	1	0	1	1	3	1	2	1	2	3	3	1	2	6	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:93649684A>C	uc001dpq.2	+	3	806	c.638A>C	c.(637-639)CAA>CCA	p.Q213P		NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	95										ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		ACTGATTTTCAAAAAAAGCCA	0.308													17	78					0	0	0	0	C	93649684	C	C	93649684	3	2	42	1	0	0	0	0	1	0	0	0	2807	130	5	5	648	5	CCDC18	1	93649684	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	7150120	93649684	155600937	8	8846											
C1orf88	128344	broad.mit.edu	37	chr1	111891150	111891150	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaacaggaaatgacacctCatgcaggcaggtaccagaaa	17	4	11	9	0	1	2	1	1	0	1	1	4	1	4	2	4	3	3	2	4	4	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:111891150C>A	uc001eaw.2	+	4	351	c.271C>A	c.(271-273)CAT>AAT	p.H91N	C1orf88_uc001eax.2_Missense_Mutation_p.H58N|C1orf88_uc009wge.1_Intron|C1orf88_uc001eay.2_Missense_Mutation_p.H4N	NM_181643	NP_857594	Q8TCI5	CA088_HUMAN	hypothetical protein LOC128344	91										ovary(1)|skin(1)	2		all_cancers(81;3.21e-05)|all_epithelial(167;1.19e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0239)|Colorectal(144;0.0301)|all cancers(265;0.0677)|Epithelial(280;0.0897)|COAD - Colon adenocarcinoma(174;0.116)|LUSC - Lung squamous cell carcinoma(189;0.135)		AATGACACCTCATGCAGGCAG	0.363													82	293					2.47556e-37	2.74936e-37	1	0	A	111891150	A	A	111891150	3	1	42	1	0	0	0	0	1	0	0	0	2075	826	29	2	285	2	C1orf88	1	111891150	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	18241466	111891150	137359471	9	8847											
BCL9	607	broad.mit.edu	37	chr1	147094302	147094302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	actcccctccagctcgttctCccaacttgccatcaatgaat	9	11	4	17	1	2	1	1	1	1	0	6	1	4	1	5	0	3	2	5	0	3	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:147094302C>T	uc001epq.2	+	9	3873	c.3133C>T	c.(3133-3135)CCC>TCC	p.P1045S	BCL9_uc010ozr.1_Missense_Mutation_p.P971S	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1045	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					AGCTCGTTCTCCCAACTTGCC	0.478			T	IGH@|IGL@	B-ALL								71	105					0	0	0	0	T	147094302	T	T	147094302	3	4	42	1	0	0	0	0	1	0	0	0	1383	855	30	2	3155	2	BCL9	1	147094302	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	35203152	147094302	102156319	10	8848											
HRNR	388697	broad.mit.edu	37	chr1	152187698	152187698	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtcctgatctagagccgTgttgtccgtagccagaggag	8	10	13	10	2	1	3	0	1	1	2	3	4	3	4	4	1	2	2	4	1	2	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:152187698T>C	uc001ezt.1	-	3	6483	c.6407A>G	c.(6406-6408)CAC>CGC	p.H2136R		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2136					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTAGAGCCGTGTTGTCCGTA	0.562													18	616					0	0	0	0	C	152187698	C	C	152187698	3	2	42	1	0	0	0	0	1	0	0	0	7398	1696	59	5	2149	5	HRNR	1	152187698	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08	5093396	152187698	97062923	11	8849											
GATAD2B	57459	broad.mit.edu	37	chr1	153788833	153788833	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcactaggcaagaaatGaagtaagggagcaggaggtt	14	6	16	5	0	0	2	0	1	0	1	0	4	0	4	0	5	2	6	0	5	5	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:153788833G>T	uc001fdb.3	-	7	1376	c.1132C>A	c.(1132-1134)CAT>AAT	p.H378N		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	378	CR2.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGCAAGAAATGAAGTAAGGGA	0.502													18	105					5.01169e-05	5.22865e-05	1	0	T	153788833	T	T	153788833	3	4	42	1	0	0	0	0	1	0	0	0	6296	1290	45	2	669	2	GATAD2B	1	153788833	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1601135	153788833	95461788	12	8850											
OR6K6	128371	broad.mit.edu	37	chr1	158724637	158724637	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcagtgggtaatcaacattCcaattataggagtctcttgt	11	15	8	7	0	3	0	2	0	1	0	5	1	4	1	1	2	1	1	1	2	5	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:158724637C>A	uc001fsw.1	+	1	32	c.32C>A	c.(31-33)TCC>TAC	p.S11Y		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					AATCAACATTCCAATTATAGG	0.393													28	87					2.12542e-12	2.26648e-12	1	0	A	158724637	A	A	158724637	3	1	42	1	0	0	0	0	1	0	0	0	11258	855	30	2	34	2	OR6K6	1	158724637	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	4935804	158724637	90525984	13	8851											
ATP1A4	480	broad.mit.edu	37	chr1	160134194	160134194	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgtggccaatgtgcctgagGggctgttggccacagtcact	6	11	14	10	0	1	1	1	1	0	0	1	1	1	1	3	4	1	2	3	4	1	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:160134194G>T	uc001fve.3	+	7	1506	c.1027G>T	c.(1027-1029)GGG>TGG	p.G343W	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_5'Flank	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	343	Helical; (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTGCCTGAGGGGCTGTTGGC	0.512													68	263					2.10328e-26	2.30405e-26	1	0	T	160134194	T	T	160134194	3	4	42	1	0	0	0	0	1	0	0	0	1133	1232	43	4	1053	4	ATP1A4	1	160134194	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1409557	160134194	89116427	14	8852											
BAT2L2	23215	broad.mit.edu	37	chr1	171492442	171492442	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttagtgcatcagaactgaagGagcttgataaatttgataac	15	12	9	5	0	1	4	1	3	0	1	1	5	1	5	0	1	4	2	0	1	6	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:171492442G>A	uc010pmg.1	+	8	1176	c.910G>A	c.(910-912)GAG>AAG	p.E304K	BAT2L2_uc001ghr.1_Missense_Mutation_p.E306K	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	304							protein C-terminus binding				0						AGAACTGAAGGAGCTTGATAA	0.448													23	29					0	0	0	0	A	171492442	A	A	171492442	3	1	42	1	0	0	0	0	1	0	0	0	1323	1175	41	2	936	2	BAT2L2	1	171492442	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	11358248	171492442	77758179	15	8853											
CACYBP	27101	broad.mit.edu	37	chr1	174977745	174977745	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttttcctgcttttcttccagGtcaagactgatacagttctt	7	18	6	10	0	3	2	1	1	2	1	5	2	5	2	2	1	2	2	2	1	2	8			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:174977745G>A	uc001gkj.1	+	5	858	c.433G>A	c.(433-435)GTC>ATC	p.V145I	CACYBP_uc001gki.1_Missense_Mutation_p.V102I	NM_014412	NP_055227	Q9HB71	CYBP_HUMAN	calcyclin binding protein isoform 1	145	Interaction with SKP1.|CS.					beta-catenin destruction complex	protein homodimerization activity				0						TTTCTTCCAGGTCAAGACTGA	0.308													21	82					0	0	0	0	A	174977745	A	A	174977745	3	1	42	1	0	0	0	0	1	0	0	0	2576	1275	44	4	451	4	CACYBP	1	174977745	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	3485303	174977745	74272876	16	8854											
IPO9	55705	broad.mit.edu	37	chr1	201824934	201824934	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtcctgggctttgaaaatCtcgtctttagcatttttgaa	10	16	8	7	1	2	2	0	2	2	0	4	2	3	2	1	1	1	2	1	1	5	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:201824934C>G	uc001gwz.2	+	10	1044	c.994C>G	c.(994-996)CTC>GTC	p.L332V		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	332					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						CTTTGAAAATCTCGTCTTTAG	0.328													24	70					0	0	0	0	G	201824934	G	G	201824934	3	3	42	1	0	0	0	0	1	0	0	0	7838	913	32	2	1032	2	IPO9	1	201824934	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	26847189	201824934	47425687	17	8855											
BTG2	7832	broad.mit.edu	37	chr1	203276399	203276399	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccagcgagctgaccctgtggGtggacccctatgaggtgtcc	6	8	14	13	1	0	2	0	2	0	0	1	4	1	3	5	3	2	1	5	3	1	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:203276399G>A	uc001gzq.2	+	2	381	c.310G>A	c.(310-312)GTG>ATG	p.V104M	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	104					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			GACCCTGTGGGTGGACCCCTA	0.652													48	82					0	0	0	0	A	203276399	A	A	203276399	3	1	42	1	0	0	0	0	1	0	0	0	1559	1261	44	4	316	4	BTG2	1	203276399	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1451465	203276399	45974222	18	8856											
LEFTY2	7044	broad.mit.edu	37	chr1	226127192	226127192	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagatgctccctctgcacCgacacctgtagcagcagcgg	8	6	10	17	2	1	1	0	0	1	1	2	2	2	1	4	1	5	5	4	1	1	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:226127192C>T	uc001hpt.1	-	3	686	c.606G>A	c.(604-606)TCG>TCA	p.S202S	LEFTY2_uc010pvk.1_Silent_p.S168S|LEFTY2_uc009xek.1_Intron	NM_003240	NP_003231	O00292	LFTY2_HUMAN	endometrial bleeding associated factor	202					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					CCCTCTGCACCGACACCTGTA	0.721													6	21					0	0	0	0	T	226127192	T	T	226127192	2	4	42	1	0	0	0	0	0	0	0	1	8756	639	23	1		1	LEFTY2	1	226127192	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	22850793	226127192	23123429	19	8857											
RYR2	6262	broad.mit.edu	37	chr1	237829847	237829847	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcccatggttacagtccccgGgccattgacatgagcaatgt	9	9	11	12	1	0	2	0	2	0	0	1	2	1	2	4	2	2	2	4	2	2	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr1:237829847G>T	uc001hyl.1	+	57	8592	c.8472G>T	c.(8470-8472)CGG>CGT	p.R2824R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2824	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.|4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACAGTCCCCGGGCCATTGACA	0.363													11	23					3.03607e-14	3.26649e-14	1	0	T	237829847	T	T	237829847	2	4	42	1	0	0	0	0	0	0	0	1	13834	1219	43	4		4	RYR2	1	237829847	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	11702655	237829847	11420774	20	8858											
APOB	338	broad.mit.edu	37	chr2	21231200	21231200	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	attttccctcaatagcatttCcaaaaaacagcatttcactc	14	13	2	12	0	2	0	2	0	0	0	5	0	4	0	2	0	3	2	2	0	5	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:21231200C>A	uc002red.2	-	26	8668	c.8540G>T	c.(8539-8541)GGA>GTA	p.G2847V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2847					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATAGCATTTCCAAAAAACAG	0.413													61	271					5.86059e-21	6.39096e-21	1	0	A	21231200	A	A	21231200	3	1	42	1	0	0	0	0	1	0	0	0	785	855	30	2	5167	2	APOB	2	21231200	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08		21231200	221968173	21	8859											
EHD3	30845	broad.mit.edu	37	chr2	31483527	31483527	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacaagatgcgagtggtgctGaacaaagctgaccagatcga	14	6	13	8	2	0	4	0	2	0	2	1	7	0	4	1	1	4	2	1	1	3	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:31483527G>C	uc002rnu.2	+	4	1262	c.654G>C	c.(652-654)CTG>CTC	p.L218L	EHD3_uc010ymt.1_Intron	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	218	Potential.				blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					GAGTGGTGCTGAACAAAGCTG	0.547													18	59					0	0	0	0	C	31483527	C	C	31483527	2	2	42	1	0	0	0	0	0	0	0	1	5001	1277	45	2		2	EHD3	2	31483527	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	10252327	31483527	211715846	22	8860											
BIRC6	57448	broad.mit.edu	37	chr2	32701366	32701366	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagtaacaaaggatcatcatAtaaactcctggtagaacaag	19	8	7	7	0	2	1	2	0	0	1	3	2	3	2	1	2	3	2	1	2	9	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:32701366A>G	uc010ezu.2	+	34	6940	c.6806A>G	c.(6805-6807)TAT>TGT	p.Y2269C		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2269					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GGATCATCATATAAACTCCTG	0.318													3	6					0	0	0	0	G	32701366	G	G	32701366	3	3	42	1	0	0	0	0	1	0	0	0	1441	449	16	5	6940	5	BIRC6	2	32701366	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	1217839	32701366	210498007	23	8861											
MAP4K3	8491	broad.mit.edu	37	chr2	39517434	39517434	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaaaataaatctgtctaccTttggtggcaaaggaggtgga	14	10	12	5	0	2	0	0	0	2	0	2	3	2	2	1	5	1	1	1	5	6	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:39517434T>A	uc002rro.2	-	19	1404	c.1313A>T	c.(1312-1314)AAG>ATG	p.K438M	MAP4K3_uc002rrp.2_Missense_Mutation_p.K417M|MAP4K3_uc010yns.1_Translation_Start_Site	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	438					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TCTGTCTACCTTTGGTGGCAA	0.303													11	56					0	0	0	0	A	39517434	A	A	39517434	3	1	42	1	0	0	0	0	1	0	0	0	9314	1623	56	5	1435	5	MAP4K3	2	39517434	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08	6816068	39517434	203681939	24	8862											
SRBD1	55133	broad.mit.edu	37	chr2	45789838	45789838	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatccttcactccatcagAaatattgaccttaaccgtca	12	13	3	13	1	4	2	4	1	0	1	6	2	6	2	4	0	1	0	4	0	3	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:45789838A>T	uc002rus.2	-	10	1439	c.1363T>A	c.(1363-1365)TCT>ACT	p.S455T	SRBD1_uc010yoc.1_5'UTR	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	455					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			ACTCCATCAGAAATATTGACC	0.338													31	130					0	0	0	0	T	45789838	T	T	45789838	3	4	42	1	0	0	0	0	1	0	0	0	15199	246	9	5	1672	5	SRBD1	2	45789838	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	6272404	45789838	197409535	25	8863											
IL18RAP	8807	broad.mit.edu	37	chr2	103061677	103061677	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactttaaaggatgaaatcAttgagcgtaatatcatcttg	14	13	7	7	1	3	2	2	2	1	0	3	3	3	3	1	1	1	1	1	1	5	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:103061677A>G	uc002tbx.2	+	9	1433	c.949A>G	c.(949-951)ATT>GTT	p.I317V	IL18RAP_uc010fiz.2_Missense_Mutation_p.I175V	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	317	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						GGATGAAATCATTGAGCGTAA	0.398													30	40					0	0	0	0	G	103061677	G	G	103061677	3	3	42	1	0	0	0	0	1	0	0	0	7687	217	8	5	975	5	IL18RAP	2	103061677	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	57271839	103061677	140137696	26	8864											
NCK2	8440	broad.mit.edu	37	chr2	106498068	106498068	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgtcttggaggaggtggacGaggcggctgcggagtcccca	7	6	18	10	4	1	0	0	0	1	0	2	5	2	4	2	7	1	1	2	7	0	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:106498068G>A	uc002tdg.2	+	4	953	c.511G>A	c.(511-513)GAG>AAG	p.E171K	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Missense_Mutation_p.E171K	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	171					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GGAGGTGGACGAGGCGGCTGC	0.657													26	79					0	0	0	0	A	106498068	A	A	106498068	3	1	42	1	0	0	0	0	1	0	0	0	10274	1059	37	1	517	1	NCK2	2	106498068	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	3436391	106498068	136701305	27	8865											
IWS1	55677	broad.mit.edu	37	chr2	128253582	128253582	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacccagctcacctcagcagCttcattcatcttgacgatca	10	10	6	15	1	6	1	5	1	1	0	6	3	6	1	2	0	3	3	2	0	0	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:128253582C>T	uc002ton.2	-	7	2011	c.1708G>A	c.(1708-1710)GCT>ACT	p.A570T	IWS1_uc010yzl.1_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	570					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		ACCTCAGCAGCTTCATTCATC	0.468													122	173					0	0	0	0	T	128253582	T	T	128253582	3	4	42	1	0	0	0	0	1	0	0	0	7970	797	28	4	783	4	IWS1	2	128253582	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	21755514	128253582	114945791	28	8866											
SLC4A10	57282	broad.mit.edu	37	chr2	162820676	162820676	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gataaagctcttctggatgcCggcaaaacatcaaccagatt	14	9	8	10	1	3	1	1	0	2	1	3	3	3	2	2	2	4	2	2	2	5	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:162820676C>T	uc002ubx.3	+	22	3078	c.2894C>T	c.(2893-2895)CCG>CTG	p.P965L	SLC4A10_uc002uby.3_Missense_Mutation_p.P935L|SLC4A10_uc010zcs.1_Missense_Mutation_p.P946L	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	965	Extracellular (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TTCTGGATGCCGGCAAAACAT	0.368													8	26					0	0	0	0	T	162820676	T	T	162820676	3	4	42	1	0	0	0	0	1	0	0	0	14715	652	23	1	3065	1	SLC4A10	2	162820676	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	34567094	162820676	80378697	29	8867											
LRP2	4036	broad.mit.edu	37	chr2	169993958	169993958	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctgagtacattgggttttCaaatattatgggctgcttcc	8	15	11	7	0	1	1	1	1	0	0	2	1	2	1	1	3	2	5	1	3	4	7			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:169993958C>G	uc002ues.2	-	76	13777	c.13564G>C	c.(13564-13566)GAA>CAA	p.E4522Q		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4522	Endocytosis signal (Potential).|Cytoplasmic (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATTGGGTTTTCAAATATTATG	0.348													37	106					0	0	0	0	G	169993958	G	G	169993958	3	3	42	1	0	0	0	0	1	0	0	0	9006	835	29	2	419	2	LRP2	2	169993958	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	7173282	169993958	73205415	30	8868											
LRP2	4036	broad.mit.edu	37	chr2	170103911	170103911	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggatgttgacatcatacGatttcaaatgcagtatgtaa	13	14	8	6	1	3	1	2	1	1	0	3	3	3	2	0	1	2	4	0	1	4	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:170103911G>T	uc002ues.2	-	20	3098	c.2885C>A	c.(2884-2886)TCG>TAG	p.S962*	LRP2_uc010zdf.1_Nonsense_Mutation_p.S825*	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	962	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GACATCATACGATTTCAAATG	0.398													26	65					5.61819e-17	6.07167e-17	1	0	T	170103911	T	T	170103911	4	4	42	1	0	0	0	0	0	1	0	0	9006	1059	37	3	11322	3	LRP2	2	170103911	Nonsense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	109953	170103911	73095462	31	8869											
CHN1	1123	broad.mit.edu	37	chr2	175742727	175742727	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttggcaatgtattctgcTgccttggtttcaatatagag	9	16	9	7	0	3	1	1	0	2	1	3	1	3	1	1	2	2	4	1	2	5	7			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:175742727T>A	uc002uji.2	-	6	920	c.390A>T	c.(388-390)GCA>GCT	p.A130A	CHN1_uc010zeq.1_Silent_p.A130A|CHN1_uc002ujj.2_Intron	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	130	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			TGTATTCTGCTGCCTTGGTTT	0.433			T	TAF15	extraskeletal myxoid chondrosarcoma								30	229					0	0	0	0	A	175742727	A	A	175742727	2	1	42	1	0	0	0	0	0	0	0	1	3377	1567	55	5		5	CHN1	2	175742727	Silent	SNP	T	TCGA-CN-4730-01A-01D-1434-08	5638816	175742727	67456646	32	8870											
CASP10	843	broad.mit.edu	37	chr2	202050586	202050586	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagcttctgattattgattCaaacctgggggtccaagatg	11	12	11	7	0	2	3	1	2	1	1	3	4	3	3	2	2	2	1	2	2	4	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:202050586C>G	uc002uxl.1	+	2	504	c.86C>G	c.(85-87)TCA>TGA	p.S29*	CASP10_uc002uxi.1_Nonsense_Mutation_p.S29*|CASP10_uc010zhn.1_RNA|CASP10_uc002uxj.1_Nonsense_Mutation_p.S29*|CASP10_uc002uxk.1_Nonsense_Mutation_p.S29*|CASP10_uc010fta.1_Nonsense_Mutation_p.S29*|CASP10_uc002uxm.1_Nonsense_Mutation_p.S29*|CASP10_uc010ftb.1_RNA	NM_032974	NP_116756	Q92851	CASPA_HUMAN	caspase 10 isoform b preproprotein	29	DED 1.				apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			skin(3)|ovary(1)|pancreas(1)|breast(1)	6						ATTATTGATTCAAACCTGGGG	0.443													27	113					0	0	0	0	G	202050586	G	G	202050586	4	3	42	1	0	0	0	0	0	1	0	0	2681	838	29	2	88	2	CASP10	2	202050586	Nonsense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	26307859	202050586	41148787	33	8871											
CD28	940	broad.mit.edu	37	chr2	204594487	204594487	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagtaacagtggcctttattAttttctgggtaagagaagca	12	14	10	5	0	1	1	0	0	1	1	1	2	1	1	1	2	2	3	1	2	6	8			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr2:204594487A>T	uc002vah.3	+	3	748	c.526A>T	c.(526-528)ATT>TTT	p.I176F	CD28_uc002vag.1_RNA|CD28_uc010zio.1_RNA|CD28_uc010ftx.2_Missense_Mutation_p.I57F|CD28_uc002vaj.3_Intron	NM_006139	NP_006130	P10747	CD28_HUMAN	CD28 antigen precursor	176	Helical; (Potential).				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity				0						GGCCTTTATTATTTTCTGGGT	0.433													126	176					0	0	0	0	T	204594487	T	T	204594487	3	4	42	1	0	0	0	0	1	0	0	0	3008	449	16	5	536	5	CD28	2	204594487	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	2543901	204594487	38604886	34	8872											
SCN10A	6336	broad.mit.edu	37	chr3	38833599	38833599	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgaaaggactgaatagccAcagggcccgagtggcactaa	13	6	13	9	1	0	2	0	2	0	0	0	4	0	3	2	3	1	2	2	3	4	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr3:38833599A>G	uc003ciq.2	-	2	331	c.331T>C	c.(331-333)TGG>CGG	p.W111R		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	111					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CTGAATAGCCACAGGGCCCGA	0.458													118	101					0	0	0	0	G	38833599	G	G	38833599	3	3	42	1	0	0	0	0	1	0	0	0	13977	159	6	5	5643	5	SCN10A	3	38833599	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08		38833599	159188831	35	8873											
NBEAL2	23218	broad.mit.edu	37	chr3	47037919	47037919	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagggcttggctgggggtcCgggctggtggcccccctgca	3	7	18	13	1	0	0	0	0	0	0	1	0	1	0	4	7	1	4	4	7	0	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr3:47037919C>T	uc003cqp.2	+	16	2489	c.2310C>T	c.(2308-2310)TCC>TCT	p.S770S	NBEAL2_uc010hjm.1_Silent_p.S331S	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	770							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GCTGGGGGTCCGGGCTGGTGG	0.716													6	11					0	0	0	0	T	47037919	T	T	47037919	2	4	42	1	0	0	0	0	0	0	0	1	10242	639	23	1		1	NBEAL2	3	47037919	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	8204320	47037919	150984511	36	8874											
TWF2	11344	broad.mit.edu	37	chr3	52269100	52269100	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagcccgtgccttggcaaaGaattccttcagctcttccgt	7	11	8	15	2	2	1	1	0	1	1	4	1	4	1	5	1	3	2	5	1	2	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr3:52269100G>C	uc003ddd.2	-	2	199	c.48C>G	c.(46-48)TTC>TTG	p.F16L	TWF2_uc010hmc.2_Missense_Mutation_p.F16L	NM_007284	NP_009215	Q6IBS0	TWF2_HUMAN	twinfilin-like protein	16	ADF-H 1.					cytoskeleton|perinuclear region of cytoplasm	actin binding|ATP binding			stomach(1)|ovary(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;2.43e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCTTGGCAAAGAATTCCTTCA	0.572													20	57					0	0	0	0	C	52269100	C	C	52269100	3	2	42	1	0	0	0	0	1	0	0	0	16850	933	33	2	1033	2	TWF2	3	52269100	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	5231181	52269100	145753330	37	8875											
KBTBD8	84541	broad.mit.edu	37	chr3	67054415	67054415	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgacatttacattgcaggaGggtacaggccaagcagcagt	13	8	12	8	0	0	1	0	1	0	0	0	2	0	2	1	3	5	4	1	3	3	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr3:67054415G>C	uc003dmy.2	+	3	1077	c.1024G>C	c.(1024-1026)GGG>CGG	p.G342R	KBTBD8_uc011bfv.1_Intron	NM_032505	NP_115894	Q8NFY9	KBTB8_HUMAN	T-cell activation kelch repeat protein	342	Kelch 1.									ovary(2)|large_intestine(1)|breast(1)	4		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		CATTGCAGGAGGGTACAGGCC	0.428													65	65					0	0	0	0	C	67054415	C	C	67054415	3	2	42	1	0	0	0	0	1	0	0	0	8038	1000	35	4	1034	4	KBTBD8	3	67054415	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	14785315	67054415	130968015	38	8876											
PHLDB2	90102	broad.mit.edu	37	chr3	111688638	111688638	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attgacacctgttaccatgtAtcaatcacagagaagacctg	14	10	7	10	0	2	3	2	1	0	2	2	4	2	3	3	0	1	2	3	0	4	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr3:111688638A>G	uc010hqa.2	+	16	3828	c.3417A>G	c.(3415-3417)GTA>GTG	p.V1139V	PHLDB2_uc003dyc.2_Silent_p.V1123V|PHLDB2_uc003dyd.2_Silent_p.V1096V|PHLDB2_uc003dyg.2_Silent_p.V1139V|PHLDB2_uc003dyh.2_Silent_p.V1096V|PHLDB2_uc003dyi.2_Silent_p.V630V|PHLDB2_uc003dyj.2_Silent_p.V194V	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1139						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GTTACCATGTATCAATCACAG	0.458													61	138					0	0	0	0	G	111688638	G	G	111688638	2	3	42	1	0	0	0	0	0	0	0	1	11907	436	16	5		5	PHLDB2	3	111688638	Silent	SNP	A	TCGA-CN-4730-01A-01D-1434-08	44634223	111688638	86333792	39	8877											
COX17	10063	broad.mit.edu	37	chr3	119396195	119396195	+	Translation_Start_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctatgagcggagacagccaAatctatgccagcctcggcaa	12	6	11	12	2	1	2	0	1	1	1	2	3	1	2	3	2	4	2	3	2	4	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr3:119396195A>T	uc003ecz.1	-	1	49	c.-37T>A	c.(-39--35)ATTTG>ATATG			NM_005694	NP_005685	Q14061	COX17_HUMAN	COX17 homolog, cytochrome c oxidase assembly						copper ion transport|generation of precursor metabolites and energy	mitochondrial intermembrane space	copper chaperone activity				0				GBM - Glioblastoma multiforme(114;0.227)		GAGACAGCCAAATCTATGCCA	0.567													4	16					0	0	0	0	T	119396195	T	T	119396195	1	4	42	1	0	0	0	0	0	0	0	0	3781	29	1	5		5	COX17	3	119396195	Translation_Start_Site	SNP	A	TCGA-CN-4730-01A-01D-1434-08	7707557	119396195	78626235	40	8878											
DHX36	170506	broad.mit.edu	37	chr3	154018467	154018467	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccatcatttctataacatcTacagtacttgcagaatacct	13	14	3	11	0	3	1	1	0	2	1	4	1	4	1	2	0	5	2	2	0	6	7			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr3:154018467T>C	uc003ezy.3	-	11	1458	c.1377A>G	c.(1375-1377)GTA>GTG	p.V459V	DHX36_uc010hvq.2_Silent_p.V459V|DHX36_uc003ezz.3_Silent_p.V459V	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	459						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CTATAACATCTACAGTACTTG	0.303													42	94					0	0	0	0	C	154018467	C	C	154018467	2	2	42	1	0	0	0	0	0	0	0	1	4531	1509	53	5		5	DHX36	3	154018467	Silent	SNP	T	TCGA-CN-4730-01A-01D-1434-08	34622272	154018467	44003963	41	8879											
PRKCI	5584	broad.mit.edu	37	chr3	170002329	170002329	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagagatttgaaactggacaAtgtattactggactctgaag	14	12	10	5	0	1	3	0	2	1	1	1	6	1	5	0	2	2	1	0	2	6	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr3:170002329A>T	uc003fgs.2	+	12	1386	c.1148A>T	c.(1147-1149)AAT>ATT	p.N383I		NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	383	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			AAACTGGACAATGTATTACTG	0.328													43	122					0	0	0	0	T	170002329	T	T	170002329	3	4	42	1	0	0	0	0	1	0	0	0	12576	101	4	5	1194	5	PRKCI	3	170002329	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	15983862	170002329	28020101	42	8880											
KLHL24	54800	broad.mit.edu	37	chr3	183368215	183368215	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgattccccagcaactaagcGaaaagtttttgaaatggacc	14	10	8	9	1	0	2	0	2	0	0	1	4	1	3	3	1	3	2	3	1	5	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr3:183368215G>A	uc003flv.2	+	3	366	c.71G>A	c.(70-72)CGA>CAA	p.R24Q	KLHL24_uc003flw.2_Missense_Mutation_p.R24Q|KLHL24_uc003flx.2_Missense_Mutation_p.R24Q	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	24						axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GCAACTAAGCGAAAAGTTTTT	0.398													52	116					0	0	0	0	A	183368215	A	A	183368215	3	1	42	1	0	0	0	0	1	0	0	0	8418	1058	37	1	73	1	KLHL24	3	183368215	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	13365886	183368215	14654215	43	8881											
TP63	8626	broad.mit.edu	37	chr3	189349235	189349235	+	Translation_Start_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcccggctttatatctatatAtacacaggtatatgtgtata	12	16	6	7	1	1	0	0	0	1	0	2	0	2	0	1	2	1	3	1	2	10	11			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr3:189349235A>G	uc003fry.2	+	1	20	c.-69A>G	c.(-71--67)ATATA>ATGTA		TP63_uc003frx.2_Translation_Start_Site|TP63_uc003frz.2_Translation_Start_Site|TP63_uc010hzc.1_Translation_Start_Site	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1						anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ATATCTATATATACACAGGTA	0.368									Hay-Wells_syndrome	HNSCC(45;0.13)			10	49					0	0	0	0	G	189349235	G	G	189349235	1	3	42	1	0	0	0	0	0	0	0	0	16459	464	16	5		5	TP63	3	189349235	Translation_Start_Site	SNP	A	TCGA-CN-4730-01A-01D-1434-08	5981020	189349235	8673195	44	8882											
RELL1	768211	broad.mit.edu	37	chr4	37633100	37633100	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctaacagacatcaggcttctCcgttccttctggtttgactt	7	15	7	12	1	3	2	1	1	2	1	5	2	4	2	2	2	1	3	2	2	1	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:37633100C>T	uc003gsz.2	-	6	816	c.726G>A	c.(724-726)CGG>CGA	p.R242R	RELL1_uc010ifc.2_Silent_p.R242R	NM_001085399	NP_001078868	Q8IUW5	RELL1_HUMAN	receptor expressed in lymphoid tissues like 1	242	Cytoplasmic (Potential).					cytoplasm|integral to membrane|microtubule cytoskeleton|plasma membrane					0						TCAGGCTTCTCCGTTCCTTCT	0.502													32	42					0	0	0	0	T	37633100	T	T	37633100	2	4	42	1	0	0	0	0	0	0	0	1	13283	842	30	2		2	RELL1	4	37633100	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08		37633100	153521176	45	8883											
C4orf14	84273	broad.mit.edu	37	chr4	57843128	57843128	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggggccgggccgccgcaaCgcggcgctcaccagctccag	6	2	16	17	6	1	0	1	0	0	0	2	1	2	0	5	4	2	3	5	4	1	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:57843128C>G	uc003hck.2	-	1	699	c.624G>C	c.(622-624)GCG>GCC	p.A208A	POLR2B_uc003hcl.1_5'Flank|POLR2B_uc011cae.1_5'Flank|POLR2B_uc011caf.1_5'Flank	NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	208							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					GCCGCCGCAACGCGGCGCTCA	0.731													14	26					0	0	0	0	G	57843128	G	G	57843128	2	3	42	1	0	0	0	0	0	0	0	1	2261	523	19	3		3	C4orf14	4	57843128	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	20210028	57843128	133311148	46	8884											
UGT2B4	7363	broad.mit.edu	37	chr4	70361310	70361310	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catctcttaaccagctgcttGataatatcctcaaactcagt	12	13	4	12	0	3	1	2	1	1	0	5	1	4	1	2	0	4	2	2	0	4	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:70361310G>C	uc003hek.3	-	1	317	c.270C>G	c.(268-270)ATC>ATG	p.I90M	UGT2B4_uc011cap.1_Intron|UGT2B4_uc003hel.3_Missense_Mutation_p.I90M	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	90					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CCAGCTGCTTGATAATATCCT	0.348													15	53					0	0	0	0	C	70361310	C	C	70361310	3	2	42	1	0	0	0	0	1	0	0	0	17029	1280	45	2	1340	2	UGT2B4	4	70361310	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	12518182	70361310	120792966	47	8885											
C4orf35	85438	broad.mit.edu	37	chr4	71201658	71201658	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccagtatttggatggagaGagatactgcaaatgaagcag	15	8	13	5	0	0	3	0	1	0	2	0	6	0	4	1	2	4	3	1	2	4	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:71201658G>C	uc003hff.2	+	1	988	c.902G>C	c.(901-903)AGA>ACA	p.R301T		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	301						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				TGGATGGAGAGAGATACTGCA	0.423													20	84					0	0	0	0	C	71201658	C	C	71201658	3	2	42	1	0	0	0	0	1	0	0	0	2275	942	33	2	904	2	C4orf35	4	71201658	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	840348	71201658	119952618	48	8886											
CXCL9	4283	broad.mit.edu	37	chr4	76927418	76927418	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacagcgaccctttctcactActggggttcctgagggaaag	10	9	11	11	1	1	1	1	1	1	0	3	3	2	2	2	3	3	1	2	3	3	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:76927418A>G	uc003hjh.1	-	2	113	c.74T>C	c.(73-75)GTA>GCA	p.V25A		NM_002416	NP_002407	Q07325	CXCL9_HUMAN	small inducible cytokine B9 precursor	25					cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTTTCTCACTACTGGGGTTCC	0.443													106	159					0	0	0	0	G	76927418	G	G	76927418	3	3	42	1	0	0	0	0	1	0	0	0	4106	391	14	5	315	5	CXCL9	4	76927418	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	5725760	76927418	114226858	49	8887											
ENOPH1	58478	broad.mit.edu	37	chr4	83375957	83375957	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tctattcctcagggagtgtgGaggcacagaaactgttattc	10	12	11	8	0	2	1	1	0	1	1	4	3	3	3	1	3	1	2	1	3	3	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:83375957G>C	uc003hmv.2	+	4	729	c.472G>C	c.(472-474)GAG>CAG	p.E158Q	ENOPH1_uc003hmw.2_Missense_Mutation_p.E70Q|ENOPH1_uc003hmx.2_Missense_Mutation_p.E12Q	NM_021204	NP_067027	Q9UHY7	ENOPH_HUMAN	enolase-phosphatase 1	158					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity				0						AGGGAGTGTGGAGGCACAGAA	0.448													50	173					0	0	0	0	C	83375957	C	C	83375957	3	2	42	1	0	0	0	0	1	0	0	0	5148	1175	41	2	486	2	ENOPH1	4	83375957	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	6448539	83375957	107778319	50	8888											
UNC5C	8633	broad.mit.edu	37	chr4	96091409	96091409	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggatagggagagggatgctGaaagcactgggccccgtgac	10	5	17	9	2	0	3	0	2	0	1	0	6	0	5	2	4	2	2	2	4	2	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:96091409G>A	uc003htp.1	-	15	2680	c.2526C>T	c.(2524-2526)TTC>TTT	p.F842F	uc003hto.2_5'Flank	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	842	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GAGGGATGCTGAAAGCACTGG	0.592													94	380					0	0	0	0	A	96091409	A	A	96091409	2	1	42	1	0	0	0	0	0	0	0	1	17061	1281	45	2		2	UNC5C	4	96091409	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	12715452	96091409	95062867	51	8889											
ALPK1	80216	broad.mit.edu	37	chr4	113352225	113352225	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atactgtgagtactactcaaGaaaagccacattgtcaaaga	17	9	7	8	0	2	3	2	1	0	2	2	3	2	3	1	0	4	1	1	0	7	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:113352225G>C	uc003iap.3	+	11	1801	c.1522G>C	c.(1522-1524)GAA>CAA	p.E508Q	ALPK1_uc003ian.3_Missense_Mutation_p.E508Q|ALPK1_uc011cfx.1_Missense_Mutation_p.E430Q|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Missense_Mutation_p.E336Q	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	508							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TACTACTCAAGAAAAGCCACA	0.398													26	67					0	0	0	0	C	113352225	C	C	113352225	3	2	42	1	0	0	0	0	1	0	0	0	544	943	33	2	1556	2	ALPK1	4	113352225	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	17260816	113352225	77802051	52	8890											
NDST3	9348	broad.mit.edu	37	chr4	119059225	119059225	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaggagcacggcattccaaCggacatgggctacgctgtgg	9	8	14	10	3	0	0	0	0	0	0	1	2	1	2	1	5	3	4	1	5	3	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:119059225C>T	uc003ibx.2	+	5	1644	c.1241C>T	c.(1240-1242)ACG>ATG	p.T414M	NDST3_uc011cgf.1_Missense_Mutation_p.T333M	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	414	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						GGCATTCCAACGGACATGGGC	0.433													6	147					0	0	0	0	T	119059225	T	T	119059225	3	4	42	1	0	0	0	0	1	0	0	0	10311	536	19	1	1255	1	NDST3	4	119059225	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	5707000	119059225	72095051	53	8891											
PRSS48	345062	broad.mit.edu	37	chr4	152203446	152203446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgtcgccttgttgaaactgtCctctcaagtcaccttcactt	7	14	6	14	2	3	1	3	1	1	0	6	1	4	1	3	0	1	1	3	0	2	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:152203446C>T	uc011cif.1	+	3	362	c.362C>T	c.(361-363)TCC>TTC	p.S121F	PRSS48_uc011cig.1_Intron	NM_183375	NP_899231	Q7RTY5	PRS48_HUMAN	epidermis-specific serine protease-like protein	121	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			large_intestine(1)	1						TTGAAACTGTCCTCTCAAGTC	0.498													46	215					0	0	0	0	T	152203446	T	T	152203446	3	4	42	1	0	0	0	0	1	0	0	0	12692	855	30	2	372	2	PRSS48	4	152203446	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	33144221	152203446	38950830	54	8892											
FBXW7	55294	broad.mit.edu	37	chr4	153250883	153250883	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcagaaccactaactattcGgttaccacaaaactgtaagc	16	9	5	11	1	1	1	1	0	0	1	2	1	1	1	2	1	5	2	2	1	7	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr4:153250883G>A	uc003ims.2	-	8	1326	c.1177C>T	c.(1177-1179)CGA>TGA	p.R393*	FBXW7_uc011cii.1_Nonsense_Mutation_p.R393*|FBXW7_uc003imt.2_Nonsense_Mutation_p.R393*|FBXW7_uc011cih.1_Nonsense_Mutation_p.R217*|FBXW7_uc003imq.2_Nonsense_Mutation_p.R313*|FBXW7_uc003imr.2_Nonsense_Mutation_p.R275*	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	393	WD 1.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R393*(5)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CTAACTATTCGGTTACCACAA	0.343			Mis|N|D|F		colorectal|endometrial|T-ALL								90	45					0	0	0	0	A	153250883	A	A	153250883	4	1	42	1	0	0	0	0	0	1	0	0	5801	1124	39	1	966	1	FBXW7	4	153250883	Nonsense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1047437	153250883	37903393	55	8893											
DNAH5	1767	broad.mit.edu	37	chr5	13841896	13841896	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaagatgcaatgaggactGagattcttccaaaagagaat	17	8	9	7	0	1	4	0	2	1	3	2	7	2	5	1	1	1	1	1	1	5	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr5:13841896G>C	uc003jfd.2	-	33	5431	c.5389C>G	c.(5389-5391)CAG>GAG	p.Q1797E		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1797	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AATGAGGACTGAGATTCTTCC	0.438									Kartagener_syndrome				30	143					0	0	0	0	C	13841896	C	C	13841896	3	2	42	1	0	0	0	0	1	0	0	0	4626	1299	45	2	8673	2	DNAH5	5	13841896	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08		13841896	167073364	56	8894											
RHOBTB3	22836	broad.mit.edu	37	chr5	95103849	95103849	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttaataagccgatgcttgccGatgttgtcttcgaaattcaa	11	14	8	8	3	2	0	1	0	1	0	3	3	2	0	2	0	3	2	2	0	4	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr5:95103849G>A	uc003klm.2	+	8	1798	c.1261G>A	c.(1261-1263)GAT>AAT	p.D421N		NM_014899	NP_055714	O94955	RHBT3_HUMAN	rho-related BTB domain containing 3	421	BTB 2.|Interaction with Rab9.				retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		GATGCTTGCCGATGTTGTCTT	0.343													30	119					0	0	0	0	A	95103849	A	A	95103849	3	1	42	1	0	0	0	0	1	0	0	0	13400	1058	37	1	1291	1	RHOBTB3	5	95103849	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	81261953	95103849	85811411	57	8895											
CXXC5	51523	broad.mit.edu	37	chr5	139060915	139060915	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgcggcatgtgcgcgccctgCcggcggcgcatcaactgcga	5	6	15	15	7	1	0	1	0	0	0	1	1	1	0	2	3	5	2	2	3	1	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr5:139060915C>T	uc010jfg.1	+	2	1097	c.807C>T	c.(805-807)TGC>TGT	p.C269C	CXXC5_uc003let.2_Silent_p.C269C	NM_016463	NP_057547	Q7LFL8	CXXC5_HUMAN	CXXC finger 5	269	CXXC-type.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCCCTGCCGGCGGCGCA	0.572													4	115					0	0	0	0	T	139060915	T	T	139060915	2	4	42	1	0	0	0	0	0	0	0	1	4116	747	26	4		4	CXXC5	5	139060915	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	43957066	139060915	41854345	58	8896											
PCDHB5	26167	broad.mit.edu	37	chr5	140517292	140517292	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgtttgaccggagactcagGggccggcgagttcaagttcc	7	9	15	10	3	2	2	2	1	0	1	3	4	3	2	3	4	0	3	3	4	1	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr5:140517292G>T	uc003liq.2	+	1	2493	c.2276G>T	c.(2275-2277)GGG>GTG	p.G759V		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	759	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGACTCAGGGGCCGGCGAG	0.582													9	242					9.70103e-10	1.02542e-09	1	0	T	140517292	T	T	140517292	3	4	42	1	0	0	0	0	1	0	0	0	11599	1232	43	4	2278	4	PCDHB5	5	140517292	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1456377	140517292	40397968	59	8897											
RELL2	285613	broad.mit.edu	37	chr5	141019628	141019628	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggagggcagcccaaggcaggGatgcctgccatggagaggct	9	4	18	10	0	0	1	0	0	0	1	0	4	0	3	3	6	3	3	3	6	1	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr5:141019628G>C	uc003lli.2	+	6	1493	c.645G>C	c.(643-645)GGG>GGC	p.G215G	RELL2_uc003llh.2_Silent_p.G215G|RELL2_uc003llg.2_Silent_p.G149G|RELL2_uc010jgf.2_Silent_p.G149G|FCHSD1_uc010jgg.2_3'UTR|FCHSD1_uc003llj.2_RNA|FCHSD1_uc003llk.2_3'UTR	NM_001130029	NP_001123501	Q8NC24	RELL2_HUMAN	RELT-like 2	215						integral to membrane|plasma membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAAGGCAGGGATGCCTGCCA	0.677													12	30					0	0	0	0	C	141019628	C	C	141019628	2	2	42	1	0	0	0	0	0	0	0	1	13284	1161	41	2		2	RELL2	5	141019628	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	502336	141019628	39895632	60	8898											
NSD1	64324	broad.mit.edu	37	chr5	176637167	176637168	+	Frame_Shift_Del	DEL	TT	-	-																															gagacttcaaatggtgactcTttattgggcttgcctgaggg																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr5:176637167_176637168delTT	uc003mfr.3	+	5	1905_1906	c.1767_1768delTT	c.(1765-1770)TCTTTAfs	p.S589fs	NSD1_uc003mft.3_Frame_Shift_Del_p.S320fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.S486fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.S237fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	589_590					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ATGGTGACTCTTTATTGGGCTT	0.446			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---								-	176637168	-	-	176637167	7	5	42	1	0	1	0	1	0	0	0	0	10723	1596	56	0	1781	0	NSD1	5	176637167	Frame_Shift_Del	DEL	TT	TCGA-CN-4730-01A-01D-1434-08	35617539	176637167	4278093	61	8899											
DTNBP1	84062	broad.mit.edu	37	chr6	15523422	15523422	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttggaacctggagggtaatCtcattctgacaggtactgga	10	12	12	7	0	2	1	1	1	2	0	3	4	2	4	1	5	2	2	1	5	3	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr6:15523422C>G	uc003nbm.2	-	10	1011	c.840G>C	c.(838-840)GAG>GAC	p.E280D	DTNBP1_uc003nbl.2_Missense_Mutation_p.E199D|DTNBP1_uc003nbn.2_RNA|DTNBP1_uc003nbo.2_RNA	NM_032122	NP_115498	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1 isoform a	280	Dysbindin.				actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding				0	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			GGAGGGTAATCTCATTCTGAC	0.498									Hermansky-Pudlak_syndrome				54	167					0	0	0	0	G	15523422	G	G	15523422	3	3	42	1	0	0	0	0	1	0	0	0	4812	912	32	2	219	2	DTNBP1	6	15523422	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08		15523422	155591645	62	8900											
HIST1H3E	8353	broad.mit.edu	37	chr6	26225622	26225622	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaatagctcaggacttcaaGaccgacctgcgcttccagag	12	7	10	12	2	2	2	2	0	0	2	3	5	3	3	3	1	2	2	3	1	3	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr6:26225622G>C	uc003nhb.2	+	2	600	c.240G>C	c.(238-240)AAG>AAC	p.K80N	HIST1H3E_uc003nhc.3_Missense_Mutation_p.K80N	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	80					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				AGGACTTCAAGACCGACCTGC	0.597													29	84					0	0	0	0	C	26225622	C	C	26225622	3	2	42	1	0	0	0	0	1	0	0	0	7198	933	33	2	242	2	HIST1H3E	6	26225622	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	10702200	26225622	144889445	63	8901											
KIF6	221458	broad.mit.edu	37	chr6	39563898	39563898	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatggccccctactccagTctttgcaactcgctctgaac	9	10	7	15	1	2	2	0	1	2	1	4	2	3	2	3	1	4	2	3	1	4	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr6:39563898T>G	uc003oot.2	-	7	873	c.778A>C	c.(778-780)ACT>CCT	p.T260P	KIF6_uc010jxa.1_Missense_Mutation_p.T51P|KIF6_uc011dua.1_Missense_Mutation_p.T260P|KIF6_uc010jxb.1_Missense_Mutation_p.T260P	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	260	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						CCTACTCCAGTCTTTGCAACT	0.443													4	105					0	0	0	0	G	39563898	G	G	39563898	3	3	42	1	0	0	0	0	1	0	0	0	8347	1667	58	5	1734	5	KIF6	6	39563898	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08	13338276	39563898	131551169	64	8902											
USP49	25862	broad.mit.edu	37	chr6	41773477	41773477	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgtgtggtgccctcagactcGagttcctgctgcaccttgtg	4	12	12	13	2	1	1	1	0	0	1	3	2	2	1	3	1	3	3	3	1	0	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr6:41773477G>C	uc003ori.2	-	4	1467	c.1245C>G	c.(1243-1245)CTC>CTG	p.L415L		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	415					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCTCAGACTCGAGTTCCTGCT	0.572													24	92					0	0	0	0	C	41773477	C	C	41773477	2	2	42	1	0	0	0	0	0	0	0	1	17148	1045	37	3		3	USP49	6	41773477	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	2209579	41773477	129341590	65	8903											
CUL9	23113	broad.mit.edu	37	chr6	43152613	43152613	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccgccggagtgcaggcaaaAtgctgcaggctctggcagcc	8	6	14	13	2	1	0	0	0	1	0	2	1	2	1	3	4	4	6	3	4	2	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr6:43152613A>G	uc003ouk.2	+	2	640	c.565A>G	c.(565-567)ATG>GTG	p.M189V	CUL9_uc003ouj.1_Missense_Mutation_p.M189V|CUL9_uc003oul.2_Missense_Mutation_p.M189V|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	189					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						TGCAGGCAAAATGCTGCAGGC	0.567													16	28					0	0	0	0	G	43152613	G	G	43152613	3	3	42	1	0	0	0	0	1	0	0	0	4078	101	4	5	567	5	CUL9	6	43152613	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	1379136	43152613	127962454	66	8904											
RFPL4B	442247	broad.mit.edu	37	chr6	112671535	112671536	+	Frame_Shift_Ins	INS	-	T	T																															tcgccttcgccgtgtgggaaINSttttcctggatgctgactta																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr6:112671535_112671536insT	uc003pvx.1	+	3	937_938	c.625_626insT	c.(625-627)ATTfs	p.I209fs		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	209	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		CCGTGTGGGAATTTTCCTGGAT	0.465													---	---	---								T	112671536	T	T	112671535	7	5	42	1	0	1	1	0	0	0	0	0	13321	101	4	0	627	0	RFPL4B	6	112671535	Frame_Shift_Ins	INS	-	TCGA-CN-4730-01A-01D-1434-08	69518922	112671535	58443532	67	8905											
ECHDC1	55862	broad.mit.edu	37	chr6	127648182	127648182	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatttcacagcattcagatCagatcctgaagagaaagtat	15	11	8	7	0	3	5	3	2	0	3	4	6	4	5	1	0	1	2	1	0	3	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr6:127648182C>T	uc003qax.2	-	3	382	c.346G>A	c.(346-348)GAT>AAT	p.D116N	ECHDC1_uc003qaz.3_Missense_Mutation_p.D110N|ECHDC1_uc010key.2_Missense_Mutation_p.D35N|ECHDC1_uc003qay.3_Missense_Mutation_p.D110N|ECHDC1_uc010kez.2_Missense_Mutation_p.D35N|ECHDC1_uc010kex.2_RNA	NM_001139510	NP_001132982	Q9NTX5	ECHD1_HUMAN	enoyl Coenzyme A hydratase domain containing 1	116							catalytic activity				0				GBM - Glioblastoma multiforme(226;0.0423)|all cancers(137;0.156)		GCATTCAGATCAGATCCTGAA	0.378													23	138					0	0	0	0	T	127648182	T	T	127648182	3	4	42	1	0	0	0	0	1	0	0	0	4915	826	29	2	593	2	ECHDC1	6	127648182	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	14976647	127648182	43466885	68	8906											
RAET1L	154064	broad.mit.edu	37	chr6	150342164	150342164	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgtcattctcccacttttCtttcatctttctggctccag	4	19	4	14	0	6	0	2	0	4	0	8	0	7	0	2	1	0	1	2	1	0	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr6:150342164C>G	uc011eei.1	-	3	569	c.508G>C	c.(508-510)GAA>CAA	p.E170Q		NM_130900	NP_570970	Q5VY80	RET1L_HUMAN	retinoic acid early transcript 1L precursor	170	MHC class I alpha-2 like (By similarity).				antigen processing and presentation|immune response	anchored to membrane|MHC class I protein complex					0		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.4e-12)		TCCCACTTTTCTTTCATCTTT	0.473													64	202					0	0	0	0	G	150342164	G	G	150342164	3	3	42	1	0	0	0	0	1	0	0	0	13066	922	32	2	239	2	RAET1L	6	150342164	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	22693982	150342164	20772903	69	8907											
WDR27	253769	broad.mit.edu	37	chr6	170060767	170060767	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaagatcttacccttgtaaTacaaagcagcttccacttcc	13	11	4	13	0	1	1	0	0	1	1	3	1	3	1	3	0	4	3	3	0	5	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr6:170060767T>C	uc003qwx.2	-	10	1641	c.1121A>G	c.(1120-1122)TAT>TGT	p.Y374C	WDR27_uc003qwv.1_RNA|WDR27_uc010kkw.1_Missense_Mutation_p.Y374C|WDR27_uc003qwy.2_Missense_Mutation_p.Y247C|WDR27_uc003qwz.1_Missense_Mutation_p.Y107C|WDR27_uc011egw.1_RNA			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	344										pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		ACCCTTGTAATACAAAGCAGC	0.443													16	49					0	0	0	0	C	170060767	C	C	170060767	3	2	42	1	0	0	0	0	1	0	0	0	17352	1406	49	5	1516	5	WDR27	6	170060767	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08	19718603	170060767	1054300	70	8908											
HOXA2	3199	broad.mit.edu	37	chr7	27140524	27140524	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcctgcaaagaggggacctCaagggcctcaggactgtcat	10	7	13	11	0	3	1	3	0	0	1	4	3	4	3	3	4	1	1	3	4	2	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr7:27140524C>T	uc003syh.2	-	2	1227	c.952G>A	c.(952-954)GAG>AAG	p.E318K		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	318						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GAGGGGACCTCAAGGGCCTCA	0.522													81	129					0	0	0	0	T	27140524	T	T	27140524	3	4	42	1	0	0	0	0	1	0	0	0	7331	835	29	2	182	2	HOXA2	7	27140524	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08		27140524	131998139	71	8909											
POM121L12	285877	broad.mit.edu	37	chr7	53104019	53104019	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccggccctctgccttcaagCccctgagcaaaaatggagcg	9	6	10	16	2	2	1	1	1	1	0	2	2	2	2	5	2	4	1	5	2	3	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr7:53104019C>T	uc003tpz.2	+	1	671	c.655C>T	c.(655-657)CCC>TCC	p.P219S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	219											0						TGCCTTCAAGCCCCTGAGCAA	0.632													12	171					0	0	0	0	T	53104019	T	T	53104019	3	4	42	1	0	0	0	0	1	0	0	0	12296	739	26	4	657	4	POM121L12	7	53104019	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	25963495	53104019	106034644	72	8910											
ZNF804B	219578	broad.mit.edu	37	chr7	88962919	88962919	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaggtactgcaaacatcttCagatctcagcaatgcaaatc	14	10	6	11	0	4	1	3	0	2	1	6	1	4	1	0	1	5	4	0	1	4	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr7:88962919C>T	uc011khi.1	+	4	1161	c.623C>T	c.(622-624)TCA>TTA	p.S208L		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	208						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CAAACATCTTCAGATCTCAGC	0.388										HNSCC(36;0.09)			26	83					0	0	0	0	T	88962919	T	T	88962919	3	4	42	1	0	0	0	0	1	0	0	0	18238	838	29	2	637	2	ZNF804B	7	88962919	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	35858900	88962919	70175744	73	8911											
COG5	10466	broad.mit.edu	37	chr7	106877029	106877029	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagacaaaatccaagcattCaaagtgtttaaaatagtcac	20	9	5	7	0	2	1	2	0	0	1	3	1	3	1	1	0	1	2	1	0	8	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr7:106877029C>G	uc003ved.2	-	17	2512	c.1987G>C	c.(1987-1989)GAA>CAA	p.E663Q	COG5_uc003vec.2_Missense_Mutation_p.E684Q|COG5_uc003vee.2_Missense_Mutation_p.E684Q	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	663					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						TCCAAGCATTCAAAGTGTTTA	0.413													26	75					0	0	0	0	G	106877029	G	G	106877029	3	3	42	1	0	0	0	0	1	0	0	0	3676	835	29	2	556	2	COG5	7	106877029	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	17914110	106877029	52261634	74	8912											
SLC26A3	1811	broad.mit.edu	37	chr7	107408040	107408040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttacctcatatacccgattaCgtaatcctccatttgtattt	10	17	3	11	2	1	0	1	0	0	0	3	1	3	0	4	0	3	2	4	0	6	8			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr7:107408040C>T	uc003ver.2	-	20	2466	c.2255G>A	c.(2254-2256)CGT>CAT	p.R752H	SLC26A3_uc003ves.2_Missense_Mutation_p.R639H	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	752					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						TACCCGATTACGTAATCCTCC	0.343													18	29					0	0	0	0	T	107408040	T	T	107408040	3	4	42	1	0	0	0	0	1	0	0	0	14582	536	19	1	47	1	SLC26A3	7	107408040	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	531011	107408040	51730623	75	8913											
C7orf58	79974	broad.mit.edu	37	chr7	120655860	120655860	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacggttgtcatcgctgaaGaaaggctcaatgctggccta	11	10	11	9	2	2	2	2	1	0	1	3	2	2	2	1	3	2	4	1	3	5	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr7:120655860G>C	uc003vjq.3	+	3	838	c.391G>C	c.(391-393)GAA>CAA	p.E131Q	C7orf58_uc003vjr.1_Missense_Mutation_p.E131Q|C7orf58_uc003vjs.3_Missense_Mutation_p.E131Q	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	131						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CATCGCTGAAGAAAGGCTCAA	0.463													11	24					0	0	0	0	C	120655860	C	C	120655860	3	2	42	1	0	0	0	0	1	0	0	0	2416	943	33	2	397	2	C7orf58	7	120655860	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	13247820	120655860	38482803	76	8914											
PIP	5304	broad.mit.edu	37	chr7	142832288	142832288	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctctcttcccacaatcagtCggaagatcataataaagaat	15	11	5	10	1	4	2	2	0	2	2	7	3	5	3	1	1	0	0	1	1	6	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr7:142832288C>T	uc003wcf.1	+	2	133	c.97C>T	c.(97-99)CGG>TGG	p.R33W		NM_002652	NP_002643	P12273	PIP_HUMAN	prolactin-induced protein precursor	33						extracellular region	actin binding			ovary(1)	1	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		CACAATCAGTCGGAAGATCAT	0.463													7	23					0	0	0	0	T	142832288	T	T	142832288	3	4	42	1	0	0	0	0	1	0	0	0	11990	898	31	1	103	1	PIP	7	142832288	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	22176428	142832288	16306375	77	8915											
SLC4A2	6522	broad.mit.edu	37	chr7	150767612	150767613	+	Silent	DNP	GC	TT	TT																															tccaagcacgagctgaaactGctggagaagattcctgagaa																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr7:150767612_150767613GC>TT	uc003wit.3	+	11	1774_1775	c.1518_1519GC>TT	c.(1516-1521)CTGCTG>CTTTTG	p.506_507LL>LL	SLC4A2_uc011kve.1_Silent_p.497_498LL>LL|SLC4A2_uc003wiu.3_Silent_p.492_493LL>LL|SLC4A2_uc003wiv.3_5'Flank	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	506_507	Cytoplasmic (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCTGAAACTGCTGGAGAAGAT	0.629													8	15					0	0	0	0	TT	150767613	TT	TT	150767612	2	4	42	1	0	0	0	0	0	0	0	1	14718	1306	46	4		4	SLC4A2	7	150767612	Silent	DNP	GC	TCGA-CN-4730-01A-01D-1434-08	7935324	150767612	8371051	78	8916											
ESYT2	57488	broad.mit.edu	37	chr7	158529772	158529772	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggatttaatgttttctttGacacgtgtgttttcctcctt	5	21	7	8	1	1	1	0	1	1	0	3	2	3	2	2	1	0	2	2	1	1	8			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr7:158529772G>C	uc003wob.1	-	19	2513	c.2447C>G	c.(2446-2448)TCA>TGA	p.S816*	ESYT2_uc003wny.1_RNA|ESYT2_uc003wnz.1_Nonsense_Mutation_p.S255*|ESYT2_uc003woa.1_Nonsense_Mutation_p.S393*	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	844	C2 3.					integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						TGTTTTCTTTGACACGTGTGT	0.448													31	137					0	0	0	0	C	158529772	C	C	158529772	4	2	42	1	0	0	0	0	0	1	0	0	5289	1294	45	2	250	2	ESYT2	7	158529772	Nonsense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	7762160	158529772	608891	79	8917											
XKR4	114786	broad.mit.edu	37	chr8	56015393	56015393	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgtgggactgcctctggatCctggccgccgtggccgtgta	3	10	15	13	3	1	0	0	0	1	0	2	2	2	2	5	4	1	1	5	4	1	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:56015393C>T	uc003xsf.2	+	1	377	c.345C>T	c.(343-345)ATC>ATT	p.I115I		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	115	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			GCCTCTGGATCCTGGCCGCCG	0.602													42	48					0	0	0	0	T	56015393	T	T	56015393	2	4	42	1	0	0	0	0	0	0	0	1	17501	845	30	2		2	XKR4	8	56015393	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08		56015393	90348629	80	8918											
PENK	5179	broad.mit.edu	37	chr8	57354258	57354258	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgaggatctcacttccattgGcctcttcttctggctccatg	5	14	8	14	1	4	0	1	0	4	0	7	2	6	1	3	3	0	1	3	3	0	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:57354258G>T	uc003xsz.2	-	2	458	c.377C>A	c.(376-378)GCC>GAC	p.A126D	PENK_uc003xta.3_Missense_Mutation_p.A126D	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	126					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			ACTTCCATTGGCCTCTTCTTC	0.502													53	205					4.17328e-34	4.59252e-34	1	0	T	57354258	T	T	57354258	3	4	42	1	0	0	0	0	1	0	0	0	11781	1203	42	4	430	4	PENK	8	57354258	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1338865	57354258	89009764	81	8919											
BHLHE22	27319	broad.mit.edu	37	chr8	65494156	65494156	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgagctgcgcgcggtgatccCctacgcgcacagcccctcgg	5	5	13	18	7	0	1	0	1	0	0	2	2	1	1	4	2	4	2	4	2	1	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:65494156C>T	uc003xvi.2	+	1	1343	c.809C>T	c.(808-810)CCC>CTC	p.P270L	LOC401463_uc003xvh.2_Intron	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	270	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GCGGTGATCCCCTACGCGCAC	0.637													5	14					0	0	0	0	T	65494156	T	T	65494156	3	4	42	1	0	0	0	0	1	0	0	0	1424	623	22	4	811	4	BHLHE22	8	65494156	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	8139898	65494156	80869866	82	8920											
DNAJC5B	85479	broad.mit.edu	37	chr8	66989019	66989019	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagagaagcatatacgacAagtacggatcgctgggactc	15	6	11	9	3	0	1	0	0	0	1	2	5	0	3	0	2	3	3	0	2	6	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:66989019A>C	uc003xvs.1	+	4	535	c.244A>C	c.(244-246)AAG>CAG	p.K82Q	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	82	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			CATATACGACAAGTACGGATC	0.463													72	112					0	0	0	0	C	66989019	C	C	66989019	3	2	42	1	0	0	0	0	1	0	0	0	4673	131	5	5	250	5	DNAJC5B	8	66989019	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	1494863	66989019	79375003	83	8921											
C8orf45	157777	broad.mit.edu	37	chr8	67796029	67796029	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaacttcaggtgtctcctCtccttaacttccagctcatg	8	13	6	14	0	4	0	2	0	2	0	7	1	5	0	3	1	3	1	3	1	2	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:67796029C>T	uc003xwz.3	+	9	1044	c.873C>T	c.(871-873)CTC>CTT	p.L291L	C8orf45_uc003xwv.2_Silent_p.L291L|C8orf45_uc011lev.1_Silent_p.L291L|C8orf45_uc011lew.1_Silent_p.L222L|C8orf45_uc011lex.1_Silent_p.L49L|C8orf45_uc003xwy.3_Silent_p.L291L	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	291					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GGTGTCTCCTCTCCTTAACTT	0.358													47	49					0	0	0	0	T	67796029	T	T	67796029	2	4	42	1	0	0	0	0	0	0	0	1	2442	900	32	2		2	C8orf45	8	67796029	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	807010	67796029	78567993	84	8922											
DCAF4L2	138009	broad.mit.edu	37	chr8	88885612	88885612	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgtactgaaagagtgataCgcgtggatgctcagggacca	11	8	13	9	2	1	3	1	2	0	1	1	5	1	5	2	2	3	2	2	2	3	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:88885612C>T	uc003ydz.2	-	1	685	c.588G>A	c.(586-588)GCG>GCA	p.A196A		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	196										ovary(1)	1						AAGAGTGATACGCGTGGATGC	0.557													51	167					0	0	0	0	T	88885612	T	T	88885612	2	4	42	1	0	0	0	0	0	0	0	1	4289	523	19	1		1	DCAF4L2	8	88885612	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	21089583	88885612	57478410	85	8923											
KIAA1429	25962	broad.mit.edu	37	chr8	95547138	95547138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggaggtggtggtggtggaGagtctctgtcatgacttatc	6	13	17	5	0	2	2	1	1	1	1	4	4	2	3	0	6	0	0	0	6	1	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:95547138G>A	uc003ygo.1	-	5	426	c.413C>T	c.(412-414)TCT>TTT	p.S138F	KIAA1429_uc003ygp.2_Missense_Mutation_p.S138F	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	138					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			tggtggtggAGAGTCTCTGTC	0.353													22	70					0	0	0	0	A	95547138	A	A	95547138	3	1	42	1	0	0	0	0	1	0	0	0	8270	942	33	2	5159	2	KIAA1429	8	95547138	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	6661526	95547138	50816884	86	8924											
VPS13B	157680	broad.mit.edu	37	chr8	100115242	100115242	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacattgtgataaataatctCatactaaaatatgttgaaga	19	13	5	4	0	1	3	1	2	1	1	2	3	1	3	0	0	2	1	0	0	9	7			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:100115242C>G	uc003yiv.2	+	5	585	c.474C>G	c.(472-474)CTC>CTG	p.L158L	VPS13B_uc003yiw.2_Silent_p.L158L|VPS13B_uc003yit.2_Silent_p.L158L|VPS13B_uc003yiu.1_Silent_p.L158L|VPS13B_uc003yis.2_Silent_p.L158L|VPS13B_uc011lgy.1_Silent_p.L34L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	158					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TAAATAATCTCATACTAAAAT	0.308													30	135					0	0	0	0	G	100115242	G	G	100115242	2	3	42	1	0	0	0	0	0	0	0	1	17258	813	29	2		2	VPS13B	8	100115242	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	4568104	100115242	46248780	87	8925											
RGS22	26166	broad.mit.edu	37	chr8	101020653	101020653	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catctttgtccatggctcaaGaaggaggagaaggatatatt	13	11	11	6	0	2	2	1	0	1	2	3	5	3	4	1	4	0	1	1	4	5	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:101020653G>A	uc003yjb.1	-	15	2506	c.2311C>T	c.(2311-2313)CTT>TTT	p.L771F	RGS22_uc003yja.1_Missense_Mutation_p.L590F|RGS22_uc003yjc.1_Missense_Mutation_p.L759F|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	771	Poly-Leu.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CATGGCTCAAGAAGGAGGAGA	0.378													35	168					0	0	0	0	A	101020653	A	A	101020653	3	1	42	1	0	0	0	0	1	0	0	0	13370	942	33	2	1535	2	RGS22	8	101020653	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	905411	101020653	45343369	88	8926											
PLEC	5339	broad.mit.edu	37	chr8	144990620	144990620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagccgcagccccgtgccctCctccaccatgctgcggtcca	5	6	9	21	3	0	0	0	0	0	0	3	0	3	0	8	1	5	2	8	1	0	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144990620C>T	uc003zaf.1	-	32	13950	c.13780G>A	c.(13780-13782)GAG>AAG	p.E4594K	PLEC_uc003zab.1_Missense_Mutation_p.E4457K|PLEC_uc003zac.1_Missense_Mutation_p.E4461K|PLEC_uc003zad.2_Missense_Mutation_p.E4457K|PLEC_uc003zae.1_Missense_Mutation_p.E4425K|PLEC_uc003zag.1_Missense_Mutation_p.E4435K|PLEC_uc003zah.2_Missense_Mutation_p.E4443K|PLEC_uc003zaj.2_Missense_Mutation_p.E4484K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4594	Globular 2.|Plectin 33.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCCGTGCCCTCCTCCACCATG	0.657													49	193					0	0	0	0	T	144990620	T	T	144990620	3	4	42	1	0	0	0	0	1	0	0	0	12107	864	30	2	278	2	PLEC	8	144990620	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	43969967	144990620	1373402	89	8927			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144993305	144993305	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcaaatgcccttcttgtctCctcctcagtgtacacctgcg	6	14	6	15	1	4	0	2	0	2	0	6	0	5	0	4	0	3	1	4	0	2	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144993305C>T	uc003zaf.1	-	32	11265	c.11095G>A	c.(11095-11097)GAG>AAG	p.E3699K	PLEC_uc003zab.1_Missense_Mutation_p.E3562K|PLEC_uc003zac.1_Missense_Mutation_p.E3566K|PLEC_uc003zad.2_Missense_Mutation_p.E3562K|PLEC_uc003zae.1_Missense_Mutation_p.E3530K|PLEC_uc003zag.1_Missense_Mutation_p.E3540K|PLEC_uc003zah.2_Missense_Mutation_p.E3548K|PLEC_uc003zaj.2_Missense_Mutation_p.E3589K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3699	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTTCTTGTCTCCTCCTCAGTG	0.637													50	235					0	0	0	0	T	144993305	T	T	144993305	3	4	42	1	0	0	0	0	1	0	0	0	12107	864	30	2	2963	2	PLEC	8	144993305	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	2685	144993305	1370717	90	8928			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144993498	144993498	+	Silent	SNP	C	T	T																															tccgccaggacgcggttcatCtcctcactgaagtagccgcg																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144993498C>T	uc003zaf.1	-	32	11072	c.10902G>A	c.(10900-10902)GAG>GAA	p.E3634E	PLEC_uc003zab.1_Silent_p.E3497E|PLEC_uc003zac.1_Silent_p.E3501E|PLEC_uc003zad.2_Silent_p.E3497E|PLEC_uc003zae.1_Silent_p.E3465E|PLEC_uc003zag.1_Silent_p.E3475E|PLEC_uc003zah.2_Silent_p.E3483E|PLEC_uc003zaj.2_Silent_p.E3524E	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3634	Globular 2.|Plectin 15.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCGGTTCATCTCCTCACTGA	0.657													37	144					0	0	0	0	T	144993498	T	T	144993498	2	4	42	1	0	0	0	0	0	0	0	1	12107	912	32	2		2	PLEC	8	144993498	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	193	144993498	1370524	91	8929	19	2	1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144993503	144993503	+	Missense_Mutation	SNP	C	T	T																															caggacgcggttcatctcctCactgaagtagccgcgctggt																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144993503C>T	uc003zaf.1	-	32	11067	c.10897G>A	c.(10897-10899)GAG>AAG	p.E3633K	PLEC_uc003zab.1_Missense_Mutation_p.E3496K|PLEC_uc003zac.1_Missense_Mutation_p.E3500K|PLEC_uc003zad.2_Missense_Mutation_p.E3496K|PLEC_uc003zae.1_Missense_Mutation_p.E3464K|PLEC_uc003zag.1_Missense_Mutation_p.E3474K|PLEC_uc003zah.2_Missense_Mutation_p.E3482K|PLEC_uc003zaj.2_Missense_Mutation_p.E3523K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3633	Globular 2.|Plectin 15.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TTCATCTCCTCACTGAAGTAG	0.662													31	138					0	0	0	0	T	144993503	T	T	144993503	3	4	42	1	0	0	0	0	1	0	0	0	12107	835	29	2	3161	2	PLEC	8	144993503	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	5	144993503	1370519	92	8930	19	2	1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144993992	144993992	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttgaccgtcgtcttgccgtCcttgagctgctcaaactggg	5	12	11	13	3	2	2	1	2	1	0	4	2	3	2	3	1	4	2	3	1	1	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144993992C>T	uc003zaf.1	-	32	10578	c.10408G>A	c.(10408-10410)GAC>AAC	p.D3470N	PLEC_uc003zab.1_Missense_Mutation_p.D3333N|PLEC_uc003zac.1_Missense_Mutation_p.D3337N|PLEC_uc003zad.2_Missense_Mutation_p.D3333N|PLEC_uc003zae.1_Missense_Mutation_p.D3301N|PLEC_uc003zag.1_Missense_Mutation_p.D3311N|PLEC_uc003zah.2_Missense_Mutation_p.D3319N|PLEC_uc003zaj.2_Missense_Mutation_p.D3360N	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3470	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTCTTGCCGTCCTTGAGCTGC	0.667													31	103					0	0	0	0	T	144993992	T	T	144993992	3	4	42	1	0	0	0	0	1	0	0	0	12107	855	30	2	3650	2	PLEC	8	144993992	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	489	144993992	1370030	93	8931			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144994286	144994286	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacctcaaccggggtcttttCaaaggtctcacgggcctgca	8	9	11	13	2	4	0	3	0	2	0	5	1	4	0	3	4	2	1	3	4	2	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144994286C>G	uc003zaf.1	-	32	10284	c.10114G>C	c.(10114-10116)GAA>CAA	p.E3372Q	PLEC_uc003zab.1_Missense_Mutation_p.E3235Q|PLEC_uc003zac.1_Missense_Mutation_p.E3239Q|PLEC_uc003zad.2_Missense_Mutation_p.E3235Q|PLEC_uc003zae.1_Missense_Mutation_p.E3203Q|PLEC_uc003zag.1_Missense_Mutation_p.E3213Q|PLEC_uc003zah.2_Missense_Mutation_p.E3221Q|PLEC_uc003zaj.2_Missense_Mutation_p.E3262Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3372	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GGGGTCTTTTCAAAGGTCTCA	0.642													24	102					0	0	0	0	G	144994286	G	G	144994286	3	3	42	1	0	0	0	0	1	0	0	0	12107	835	29	2	3944	2	PLEC	8	144994286	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	294	144994286	1369736	94	8932			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144994712	144994712	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcggctgatagcagcttctCatgaaactcggggcccacca	9	8	10	14	2	1	2	1	2	1	0	4	2	1	2	2	3	3	3	2	3	2	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144994712C>T	uc003zaf.1	-	32	9858	c.9688G>A	c.(9688-9690)GAG>AAG	p.E3230K	PLEC_uc003zab.1_Missense_Mutation_p.E3093K|PLEC_uc003zac.1_Missense_Mutation_p.E3097K|PLEC_uc003zad.2_Missense_Mutation_p.E3093K|PLEC_uc003zae.1_Missense_Mutation_p.E3061K|PLEC_uc003zag.1_Missense_Mutation_p.E3071K|PLEC_uc003zah.2_Missense_Mutation_p.E3079K|PLEC_uc003zaj.2_Missense_Mutation_p.E3120K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3230	Plectin 9.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGCAGCTTCTCATGAAACTCG	0.662													15	57					0	0	0	0	T	144994712	T	T	144994712	3	4	42	1	0	0	0	0	1	0	0	0	12107	835	29	2	4370	2	PLEC	8	144994712	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	426	144994712	1369310	95	8933			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144995096	144995096	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccggcccttctgctcctgctCctccaccaccgtgatgatga	5	10	8	18	2	1	3	0	3	1	0	4	3	4	3	7	1	2	2	7	1	0	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144995096C>T	uc003zaf.1	-	32	9474	c.9304G>A	c.(9304-9306)GAG>AAG	p.E3102K	PLEC_uc003zab.1_Missense_Mutation_p.E2965K|PLEC_uc003zac.1_Missense_Mutation_p.E2969K|PLEC_uc003zad.2_Missense_Mutation_p.E2965K|PLEC_uc003zae.1_Missense_Mutation_p.E2933K|PLEC_uc003zag.1_Missense_Mutation_p.E2943K|PLEC_uc003zah.2_Missense_Mutation_p.E2951K|PLEC_uc003zaj.2_Missense_Mutation_p.E2992K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3102	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TGCTCCTGCTCCTCCACCACC	0.637													18	49					0	0	0	0	T	144995096	T	T	144995096	3	4	42	1	0	0	0	0	1	0	0	0	12107	864	30	2	4754	2	PLEC	8	144995096	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	384	144995096	1368926	96	8934			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144995838	144995838	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgggactcagcagctgcctCtgcagggcggcgtaaacact	8	6	13	14	3	2	0	1	0	1	0	2	1	2	1	2	3	5	4	2	3	2	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144995838C>T	uc003zaf.1	-	32	8732	c.8562G>A	c.(8560-8562)CAG>CAA	p.Q2854Q	PLEC_uc003zab.1_Silent_p.Q2717Q|PLEC_uc003zac.1_Silent_p.Q2721Q|PLEC_uc003zad.2_Silent_p.Q2717Q|PLEC_uc003zae.1_Silent_p.Q2685Q|PLEC_uc003zag.1_Silent_p.Q2695Q|PLEC_uc003zah.2_Silent_p.Q2703Q|PLEC_uc003zaj.2_Silent_p.Q2744Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2854	Plectin 1.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCAGCTGCCTCTGCAGGGCGG	0.672													21	42					0	0	0	0	T	144995838	T	T	144995838	2	4	42	1	0	0	0	0	0	0	0	1	12107	912	32	2		2	PLEC	8	144995838	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	742	144995838	1368184	97	8935			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144996072	144996073	+	Frame_Shift_Ins	INS	-	T	T																															agctgtgctccggctctgccINStctgccgcggggccatcaag																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144996072_144996073insT	uc003zaf.1	-	32	8497_8498	c.8327_8328insA	c.(8326-8328)GAGfs	p.E2776fs	PLEC_uc003zab.1_Frame_Shift_Ins_p.E2639fs|PLEC_uc003zac.1_Frame_Shift_Ins_p.E2643fs|PLEC_uc003zad.2_Frame_Shift_Ins_p.E2639fs|PLEC_uc003zae.1_Frame_Shift_Ins_p.E2607fs|PLEC_uc003zag.1_Frame_Shift_Ins_p.E2617fs|PLEC_uc003zah.2_Frame_Shift_Ins_p.E2625fs|PLEC_uc003zaj.2_Frame_Shift_Ins_p.E2666fs	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2776	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCGGCTCTGCCTCTGCCGCGGG	0.688													---	---	---								T	144996073	T	T	144996072	7	5	42	1	0	1	1	0	0	0	0	0	12107	680	24	0	5730	0	PLEC	8	144996072	Frame_Shift_Ins	INS	-	TCGA-CN-4730-01A-01D-1434-08	234	144996072	1367950	98	8936			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144997355	144997355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtgcgcggttctcagcctCgatgcgtgccttgagcttgc	4	11	14	12	4	1	1	1	1	1	0	3	3	1	1	2	1	6	2	2	1	0	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144997355C>T	uc003zaf.1	-	31	7323	c.7153G>A	c.(7153-7155)GAG>AAG	p.E2385K	PLEC_uc003zab.1_Missense_Mutation_p.E2248K|PLEC_uc003zac.1_Missense_Mutation_p.E2252K|PLEC_uc003zad.2_Missense_Mutation_p.E2248K|PLEC_uc003zae.1_Missense_Mutation_p.E2216K|PLEC_uc003zag.1_Missense_Mutation_p.E2226K|PLEC_uc003zah.2_Missense_Mutation_p.E2234K|PLEC_uc003zaj.2_Missense_Mutation_p.E2275K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2385	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TTCTCAGCCTCGATGCGTGCC	0.647													10	48					0	0	0	0	T	144997355	T	T	144997355	3	4	42	1	0	0	0	0	1	0	0	0	12107	893	31	1	6909	1	PLEC	8	144997355	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	1283	144997355	1366667	99	8937			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144997461	144997461	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctccgtggcctccgccttCagccgctgcagctcctcgtc	2	9	10	20	4	1	0	1	0	0	0	6	0	4	0	7	1	3	3	7	1	0	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144997461C>T	uc003zaf.1	-	31	7217	c.7047G>A	c.(7045-7047)CTG>CTA	p.L2349L	PLEC_uc003zab.1_Silent_p.L2212L|PLEC_uc003zac.1_Silent_p.L2216L|PLEC_uc003zad.2_Silent_p.L2212L|PLEC_uc003zae.1_Silent_p.L2180L|PLEC_uc003zag.1_Silent_p.L2190L|PLEC_uc003zah.2_Silent_p.L2198L|PLEC_uc003zaj.2_Silent_p.L2239L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2349	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCTCCGCCTTCAGCCGCTGCA	0.667													8	17					0	0	0	0	T	144997461	T	T	144997461	2	4	42	1	0	0	0	0	0	0	0	1	12107	813	29	2		2	PLEC	8	144997461	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	106	144997461	1366561	100	8938			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144997511	144997511	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttctggtggtcggtctcctCcagctgcagccgcagtgttg	3	12	13	13	2	2	0	0	0	2	0	5	0	3	0	3	3	3	4	3	3	0	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144997511C>T	uc003zaf.1	-	31	7167	c.6997G>A	c.(6997-6999)GAG>AAG	p.E2333K	PLEC_uc003zab.1_Missense_Mutation_p.E2196K|PLEC_uc003zac.1_Missense_Mutation_p.E2200K|PLEC_uc003zad.2_Missense_Mutation_p.E2196K|PLEC_uc003zae.1_Missense_Mutation_p.E2164K|PLEC_uc003zag.1_Missense_Mutation_p.E2174K|PLEC_uc003zah.2_Missense_Mutation_p.E2182K|PLEC_uc003zaj.2_Missense_Mutation_p.E2223K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2333	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCGGTCTCCTCCAGCTGCAGC	0.652													7	22					0	0	0	0	T	144997511	T	T	144997511	3	4	42	1	0	0	0	0	1	0	0	0	12107	864	30	2	7065	2	PLEC	8	144997511	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	50	144997511	1366511	101	8939			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144997545	144997545	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgttgtcagctcctgctcCacctgcgccttctgccgcag	4	11	10	16	2	2	0	1	0	1	0	4	0	4	0	5	0	4	4	5	0	0	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144997545C>T	uc003zaf.1	-	31	7133	c.6963G>A	c.(6961-6963)GTG>GTA	p.V2321V	PLEC_uc003zab.1_Silent_p.V2184V|PLEC_uc003zac.1_Silent_p.V2188V|PLEC_uc003zad.2_Silent_p.V2184V|PLEC_uc003zae.1_Silent_p.V2152V|PLEC_uc003zag.1_Silent_p.V2162V|PLEC_uc003zah.2_Silent_p.V2170V|PLEC_uc003zaj.2_Silent_p.V2211V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2321	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCTCCTGCTCCACCTGCGCCT	0.657													5	27					0	0	0	0	T	144997545	T	T	144997545	2	4	42	1	0	0	0	0	0	0	0	1	12107	581	21	4		4	PLEC	8	144997545	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	34	144997545	1366477	102	8940			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144997569	144997569	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcgccttctgccgcagcgtCtgctcggcgaatttcttatg	4	13	11	13	5	3	0	0	0	3	0	4	1	3	0	2	1	4	2	2	1	2	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144997569C>T	uc003zaf.1	-	31	7109	c.6939G>A	c.(6937-6939)CAG>CAA	p.Q2313Q	PLEC_uc003zab.1_Silent_p.Q2176Q|PLEC_uc003zac.1_Silent_p.Q2180Q|PLEC_uc003zad.2_Silent_p.Q2176Q|PLEC_uc003zae.1_Silent_p.Q2144Q|PLEC_uc003zag.1_Silent_p.Q2154Q|PLEC_uc003zah.2_Silent_p.Q2162Q|PLEC_uc003zaj.2_Silent_p.Q2203Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2313	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCGCAGCGTCTGCTCGGCGA	0.662													5	35					0	0	0	0	T	144997569	T	T	144997569	2	4	42	1	0	0	0	0	0	0	0	1	12107	912	32	2		2	PLEC	8	144997569	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	24	144997569	1366453	103	8941			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144997754	144997754	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccgactgcttcagccgctCggcctcttccacctgccgcc	3	9	9	20	4	2	0	1	0	1	0	4	1	3	0	7	1	4	2	7	1	0	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144997754C>T	uc003zaf.1	-	31	6924	c.6754G>A	c.(6754-6756)GAG>AAG	p.E2252K	PLEC_uc003zab.1_Missense_Mutation_p.E2115K|PLEC_uc003zac.1_Missense_Mutation_p.E2119K|PLEC_uc003zad.2_Missense_Mutation_p.E2115K|PLEC_uc003zae.1_Missense_Mutation_p.E2083K|PLEC_uc003zag.1_Missense_Mutation_p.E2093K|PLEC_uc003zah.2_Missense_Mutation_p.E2101K|PLEC_uc003zaj.2_Missense_Mutation_p.E2142K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2252	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TTCAGCCGCTCGGCCTCTTCC	0.761													6	14					0	0	0	0	T	144997754	T	T	144997754	3	4	42	1	0	0	0	0	1	0	0	0	12107	893	31	1	7308	1	PLEC	8	144997754	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	185	144997754	1366268	104	8942			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144998138	144998138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcttctgcacgcgctcctCagcctcacggcgccgccgct	3	8	10	20	6	4	0	2	0	2	0	5	0	5	0	4	1	2	4	4	1	0	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144998138C>T	uc003zaf.1	-	31	6540	c.6370G>A	c.(6370-6372)GAG>AAG	p.E2124K	PLEC_uc003zab.1_Missense_Mutation_p.E1987K|PLEC_uc003zac.1_Missense_Mutation_p.E1991K|PLEC_uc003zad.2_Missense_Mutation_p.E1987K|PLEC_uc003zae.1_Missense_Mutation_p.E1955K|PLEC_uc003zag.1_Missense_Mutation_p.E1965K|PLEC_uc003zah.2_Missense_Mutation_p.E1973K|PLEC_uc003zaj.2_Missense_Mutation_p.E2014K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2124	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						ACGCGCTCCTCAGCCTCACGG	0.726													3	11					0	0	0	0	T	144998138	T	T	144998138	3	4	42	1	0	0	0	0	1	0	0	0	12107	835	29	2	7692	2	PLEC	8	144998138	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	384	144998138	1365884	105	8943			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144998210	144998210	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agcctccagctcggcctgctCcttgctgcgcagcgtgtcct	3	10	11	17	3	0	0	0	0	0	0	4	0	3	0	5	1	6	4	5	1	0	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144998210C>G	uc003zaf.1	-	31	6468	c.6298G>C	c.(6298-6300)GAG>CAG	p.E2100Q	PLEC_uc003zab.1_Missense_Mutation_p.E1963Q|PLEC_uc003zac.1_Missense_Mutation_p.E1967Q|PLEC_uc003zad.2_Missense_Mutation_p.E1963Q|PLEC_uc003zae.1_Missense_Mutation_p.E1931Q|PLEC_uc003zag.1_Missense_Mutation_p.E1941Q|PLEC_uc003zah.2_Missense_Mutation_p.E1949Q|PLEC_uc003zaj.2_Missense_Mutation_p.E1990Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2100	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCGGCCTGCTCCTTGCTGCGC	0.726													5	17					0	0	0	0	G	144998210	G	G	144998210	3	3	42	1	0	0	0	0	1	0	0	0	12107	864	30	2	7764	2	PLEC	8	144998210	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	72	144998210	1365812	106	8944			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144998264	144998264	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatgcgtcccagctccagctCcagctccgccttgccagcgg	5	7	11	18	3	0	0	0	0	0	0	4	1	4	0	6	1	6	3	6	1	0	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144998264C>G	uc003zaf.1	-	31	6414	c.6244G>C	c.(6244-6246)GAG>CAG	p.E2082Q	PLEC_uc003zab.1_Missense_Mutation_p.E1945Q|PLEC_uc003zac.1_Missense_Mutation_p.E1949Q|PLEC_uc003zad.2_Missense_Mutation_p.E1945Q|PLEC_uc003zae.1_Missense_Mutation_p.E1913Q|PLEC_uc003zag.1_Missense_Mutation_p.E1923Q|PLEC_uc003zah.2_Missense_Mutation_p.E1931Q|PLEC_uc003zaj.2_Missense_Mutation_p.E1972Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2082	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGCTCCAGCTCCAGCTCCGCC	0.711													3	27					0	0	0	0	G	144998264	G	G	144998264	3	3	42	1	0	0	0	0	1	0	0	0	12107	864	30	2	7818	2	PLEC	8	144998264	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	54	144998264	1365758	107	8945			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144998319	144998319	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcgccttcagcgccaggatCtcctcctccacctgccgccg	4	8	8	21	4	2	0	1	0	1	0	6	1	4	1	8	1	2	0	8	1	0	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144998319C>G	uc003zaf.1	-	31	6359	c.6189G>C	c.(6187-6189)GAG>GAC	p.E2063D	PLEC_uc003zab.1_Missense_Mutation_p.E1926D|PLEC_uc003zac.1_Missense_Mutation_p.E1930D|PLEC_uc003zad.2_Missense_Mutation_p.E1926D|PLEC_uc003zae.1_Missense_Mutation_p.E1894D|PLEC_uc003zag.1_Missense_Mutation_p.E1904D|PLEC_uc003zah.2_Missense_Mutation_p.E1912D|PLEC_uc003zaj.2_Missense_Mutation_p.E1953D	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2063	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCGCCAGGATCTCCTCCTCCA	0.701													4	34					0	0	0	0	G	144998319	G	G	144998319	3	3	42	1	0	0	0	0	1	0	0	0	12107	912	32	2	7873	2	PLEC	8	144998319	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	55	144998319	1365703	108	8946			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144998346	144998346	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccacctgccgccgctgcctCagcgtgtcctccaccagccc	4	7	8	22	3	1	0	1	0	0	0	4	0	4	0	9	0	4	1	9	0	0	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144998346C>G	uc003zaf.1	-	31	6332	c.6162G>C	c.(6160-6162)CTG>CTC	p.L2054L	PLEC_uc003zab.1_Silent_p.L1917L|PLEC_uc003zac.1_Silent_p.L1921L|PLEC_uc003zad.2_Silent_p.L1917L|PLEC_uc003zae.1_Silent_p.L1885L|PLEC_uc003zag.1_Silent_p.L1895L|PLEC_uc003zah.2_Silent_p.L1903L|PLEC_uc003zaj.2_Silent_p.L1944L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2054	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCGCTGCCTCAGCGTGTCCT	0.692													5	23					0	0	0	0	G	144998346	G	G	144998346	2	3	42	1	0	0	0	0	0	0	0	1	12107	813	29	2		2	PLEC	8	144998346	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	27	144998346	1365676	109	8947			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144998529	144998529	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctccgcctccttctccttGagcgcgatctccgcctccgt	2	13	7	19	5	3	1	0	1	3	0	8	2	5	1	7	0	1	0	7	0	0	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144998529G>A	uc003zaf.1	-	31	6149	c.5979C>T	c.(5977-5979)CTC>CTT	p.L1993L	PLEC_uc003zab.1_Silent_p.L1856L|PLEC_uc003zac.1_Silent_p.L1860L|PLEC_uc003zad.2_Silent_p.L1856L|PLEC_uc003zae.1_Silent_p.L1824L|PLEC_uc003zag.1_Silent_p.L1834L|PLEC_uc003zah.2_Silent_p.L1842L|PLEC_uc003zaj.2_Silent_p.L1883L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1993	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCTTCTCCTTGAGCGCGATCT	0.741													10	19					0	0	0	0	A	144998529	A	A	144998529	2	1	42	1	0	0	0	0	0	0	0	1	12107	1277	45	2		2	PLEC	8	144998529	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	183	144998529	1365493	110	8948			1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144999083	144999083	+	Missense_Mutation	SNP	C	T	T																															cttgccgcgccgccgcgcctCgcgctccgcctcctccttct																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144999083C>T	uc003zaf.1	-	31	5595	c.5425G>A	c.(5425-5427)GAG>AAG	p.E1809K	PLEC_uc003zab.1_Missense_Mutation_p.E1672K|PLEC_uc003zac.1_Missense_Mutation_p.E1676K|PLEC_uc003zad.2_Missense_Mutation_p.E1672K|PLEC_uc003zae.1_Missense_Mutation_p.E1640K|PLEC_uc003zag.1_Missense_Mutation_p.E1650K|PLEC_uc003zah.2_Missense_Mutation_p.E1658K|PLEC_uc003zaj.2_Missense_Mutation_p.E1699K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1809	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCCGCGCCTCGCGCTCCGCC	0.726													9	14					0	0	0	0	T	144999083	T	T	144999083	3	4	42	1	0	0	0	0	1	0	0	0	12107	893	31	1	8637	1	PLEC	8	144999083	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	554	144999083	1364939	111	8949	20	2	1	12		24	22	8470	N	G_C_-	3.374047e-47
PLEC	5339	broad.mit.edu	37	chr8	144999089	144999089	+	Missense_Mutation	SNP	C	G	G																															gcgccgccgcgcctcgcgctCcgcctcctccttctgcttct																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr8:144999089C>G	uc003zaf.1	-	31	5589	c.5419G>C	c.(5419-5421)GAG>CAG	p.E1807Q	PLEC_uc003zab.1_Missense_Mutation_p.E1670Q|PLEC_uc003zac.1_Missense_Mutation_p.E1674Q|PLEC_uc003zad.2_Missense_Mutation_p.E1670Q|PLEC_uc003zae.1_Missense_Mutation_p.E1638Q|PLEC_uc003zag.1_Missense_Mutation_p.E1648Q|PLEC_uc003zah.2_Missense_Mutation_p.E1656Q|PLEC_uc003zaj.2_Missense_Mutation_p.E1697Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1807	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCTCGCGCTCCGCCTCCTCC	0.721													7	13					0	0	0	0	G	144999089	G	G	144999089	3	3	42	1	0	0	0	0	1	0	0	0	12107	864	30	2	8643	2	PLEC	8	144999089	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	6	144999089	1364933	112	8950	20	2	1	12		24	22	8470	N	G_C_-	3.374047e-47
CNTLN	54875	broad.mit.edu	37	chr9	17409412	17409412	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatccaacagaagacagcCaaacacaaggaaaagaaata	22	3	8	8	0	0	4	0	1	0	3	1	5	1	5	2	1	3	0	2	1	8	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr9:17409412C>A	uc003zmz.2	+	16	2760	c.2734C>A	c.(2734-2736)CAA>AAA	p.Q912K	CNTLN_uc003zmy.2_Missense_Mutation_p.Q913K|CNTLN_uc010mio.2_Missense_Mutation_p.Q592K	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	913						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		AGAAGACAGCCAAACACAAGG	0.343													39	146					2.05212e-20	2.22775e-20	1	0	A	17409412	A	A	17409412	3	1	42	1	0	0	0	0	1	0	0	0	3654	595	21	4	2829	4	CNTLN	9	17409412	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08		17409412	123804019	113	8951											
MLLT3	4300	broad.mit.edu	37	chr9	20346501	20346501	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggactgtggttttgtccagCgagcaaagatcaaaatcaaa	14	9	10	8	2	2	1	2	0	0	1	3	3	3	2	1	2	2	2	1	2	4	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr9:20346501C>A	uc003zoe.2	-	11	1906	c.1647G>T	c.(1645-1647)TCG>TCT	p.S549S	MLLT3_uc011lne.1_Silent_p.S517S|MLLT3_uc011lnf.1_Silent_p.S546S	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	549					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TTTTGTCCAGCGAGCAAAGAT	0.388			T	MLL	ALL								3	84					0.004672	0.00479129	1	0	A	20346501	A	A	20346501	2	1	42	1	0	0	0	0	0	0	0	1	9681	755	27	3		3	MLLT3	9	20346501	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	2937089	20346501	120866930	114	8952											
KIAA1797	54914	broad.mit.edu	37	chr9	20986380	20986380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgatatgctgagcgttgctGtgcagcaccgtgagaaagag	10	8	14	9	3	0	3	0	2	0	2	0	5	0	3	2	0	5	5	2	0	2	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr9:20986380G>A	uc003zog.1	+	42	5185	c.4822G>A	c.(4822-4824)GTG>ATG	p.V1608M	KIAA1797_uc003zoh.1_Missense_Mutation_p.V1044M	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1608						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		GAGCGTTGCTGTGCAGCACCG	0.512													35	38					0	0	0	0	A	20986380	A	A	20986380	3	1	42	1	0	0	0	0	1	0	0	0	8297	1377	48	4	4976	4	KIAA1797	9	20986380	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	639879	20986380	120227051	115	8953											
PTPDC1	138639	broad.mit.edu	37	chr9	96860086	96860086	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcagcagattttgacaatcGaggcatgattttctccaatg	11	12	10	8	1	1	3	0	2	1	1	3	4	1	3	1	2	1	3	1	2	2	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr9:96860086G>A	uc004auf.1	+	7	1416	c.1076G>A	c.(1075-1077)CGA>CAA	p.R359Q	PTPDC1_uc004aug.1_Missense_Mutation_p.R359Q|PTPDC1_uc004auh.1_Missense_Mutation_p.R411Q|PTPDC1_uc010mrj.1_Missense_Mutation_p.R413Q|PTPDC1_uc010mri.1_Missense_Mutation_p.R411Q	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	359							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1						TTTGACAATCGAGGCATGATT	0.502													21	110					0	0	0	0	A	96860086	A	A	96860086	3	1	42	1	0	0	0	0	1	0	0	0	12836	1058	37	1	1340	1	PTPDC1	9	96860086	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	75873706	96860086	44353345	116	8954											
ODF2	4957	broad.mit.edu	37	chr9	131260723	131260723	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgaccagtgcccagaatatcGagttcctacaggtgattgcc	10	9	10	12	2	0	2	0	1	0	1	2	4	1	2	4	1	3	1	4	1	3	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr9:131260723G>C	uc011mbd.1	+	19	2355	c.2044G>C	c.(2044-2046)GAG>CAG	p.E682Q	ODF2_uc004bvb.2_Missense_Mutation_p.E658Q|ODF2_uc011mbe.1_Missense_Mutation_p.E677Q|ODF2_uc004bvc.2_Missense_Mutation_p.E658Q|ODF2_uc004bvd.3_Missense_Mutation_p.E682Q|ODF2_uc004bvh.2_Missense_Mutation_p.E88Q	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	682	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						CCAGAATATCGAGTTCCTACA	0.537													5	17					0	0	0	0	C	131260723	C	C	131260723	3	2	42	1	0	0	0	0	1	0	0	0	10881	1059	37	3	2232	3	ODF2	9	131260723	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	34400637	131260723	9952708	117	8955			2	13		3	3	624	G		7.667855e-06
ODF2	4957	broad.mit.edu	37	chr9	131260797	131260797	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggctggaggagaaaacacgGgaatgtgggaccctggcaag	12	4	17	8	2	0	1	0	0	0	1	0	5	0	4	1	6	1	2	1	6	4	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr9:131260797G>A	uc011mbd.1	+	19	2429	c.2118G>A	c.(2116-2118)CGG>CGA	p.R706R	ODF2_uc004bvb.2_Silent_p.R682R|ODF2_uc011mbe.1_Silent_p.R701R|ODF2_uc004bvc.2_Silent_p.R682R|ODF2_uc004bvd.3_Silent_p.R706R|ODF2_uc004bvh.2_Silent_p.R112R	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	706	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						AGAAAACACGGGAATGTGGGA	0.328													4	16					0	0	0	0	A	131260797	A	A	131260797	2	1	42	1	0	0	0	0	0	0	0	1	10881	1219	43	4		4	ODF2	9	131260797	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	74	131260797	9952634	118	8956			2	13		3	3	624	G		7.667855e-06
ODF2	4957	broad.mit.edu	37	chr9	131261346	131261346	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaacaaaatcctggaccttGagacccagctgagcagaacc	15	5	9	12	0	0	4	0	2	0	3	1	6	1	5	4	1	4	2	4	1	4	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr9:131261346G>C	uc011mbd.1	+	20	2553	c.2242G>C	c.(2242-2244)GAG>CAG	p.E748Q	ODF2_uc004bvb.2_Missense_Mutation_p.E724Q|ODF2_uc011mbe.1_Missense_Mutation_p.E743Q|ODF2_uc004bvc.2_Missense_Mutation_p.E724Q|ODF2_uc004bvd.3_Missense_Mutation_p.E748Q|ODF2_uc004bvh.2_Missense_Mutation_p.E154Q	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	748	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						CCTGGACCTTGAGACCCAGCT	0.577													39	134					0	0	0	0	C	131261346	C	C	131261346	3	2	42	1	0	0	0	0	1	0	0	0	10881	1291	45	2	2434	2	ODF2	9	131261346	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	549	131261346	9952085	119	8957			2	13		3	3	624	G		7.667855e-06
CUBN	8029	broad.mit.edu	37	chr10	16994278	16994278	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcatttttgttacttacatgGaggttgcgcttgaatgatcc	8	17	9	7	1	1	2	1	2	0	0	2	3	2	3	1	2	3	3	1	2	3	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr10:16994278G>C	uc001ioo.2	-	33	5018	c.4966C>G	c.(4966-4968)CCA>GCA	p.P1656A		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1656	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TACTTACATGGAGGTTGCGCT	0.438													26	89					0	0	0	0	C	16994278	C	C	16994278	3	2	42	1	0	0	0	0	1	0	0	0	4068	1174	41	2	6045	2	CUBN	10	16994278	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08		16994278	118540469	120	8958											
SVIL	6840	broad.mit.edu	37	chr10	29762869	29762869	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaagaagtagacgcacttCtctttgccggctgccctcac	9	9	9	14	2	2	3	1	0	1	3	3	3	2	3	2	1	2	3	2	1	3	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr10:29762869C>G	uc001iut.1	-	30	6180	c.5427G>C	c.(5425-5427)GAG>GAC	p.E1809D	LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Missense_Mutation_p.E723D|SVIL_uc001iuu.1_Missense_Mutation_p.E1383D	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1809	Gelsolin-like 3.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AGACGCACTTCTCTTTGCCGG	0.627													15	50					0	0	0	0	G	29762869	G	G	29762869	3	3	42	1	0	0	0	0	1	0	0	0	15487	912	32	2	1253	2	SVIL	10	29762869	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	12768591	29762869	105771878	121	8959											
MAP3K8	1326	broad.mit.edu	37	chr10	30749693	30749693	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaagaggcaacgctctctCtacatcgacctcggcgctct	8	9	8	16	4	4	1	1	0	3	1	7	2	4	1	1	2	2	3	1	2	3	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr10:30749693C>T	uc001ivi.1	+	9	2028	c.1332C>T	c.(1330-1332)CTC>CTT	p.L444L	MAP3K8_uc009xlf.1_Silent_p.L444L|MAP3K8_uc001ivj.1_Silent_p.L444L	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	444			Missing (in oncogenic form).		cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)				AACGCTCTCTCTACATCGACC	0.463													73	110					0	0	0	0	T	30749693	T	T	30749693	2	4	42	1	0	0	0	0	0	0	0	1	9309	900	32	2		2	MAP3K8	10	30749693	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	986824	30749693	104785054	122	8960											
C10orf79	80217	broad.mit.edu	37	chr10	105974155	105974155	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccattccaggctgtgatttcTtacacaaaatgatactcgat	12	13	6	10	1	1	2	0	2	1	0	3	3	2	2	2	1	2	1	2	1	4	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr10:105974155T>G	uc001kxw.2	-	4	562	c.446A>C	c.(445-447)AAG>ACG	p.K149T	C10orf79_uc001kxx.3_Missense_Mutation_p.K149T|C10orf79_uc001kxy.1_Missense_Mutation_p.K149T|C10orf79_uc001kxz.2_Missense_Mutation_p.K149T	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	149	WD 1.										0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		CTGTGATTTCTTACACAAAAT	0.373													42	56					0	0	0	0	G	105974155	G	G	105974155	3	3	42	1	0	0	0	0	1	0	0	0	1624	1609	56	5	4691	5	C10orf79	10	105974155	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08	75224462	105974155	29560592	123	8961											
SORCS3	22986	broad.mit.edu	37	chr10	107022174	107022174	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgagccaaagtgaaaacGcccccaaaatcacactcagt	16	5	7	13	1	2	2	2	2	0	0	2	2	2	2	3	0	2	0	3	0	5	0	rs140421862		TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr10:107022174G>A	uc001kyi.1	+	26	3756	c.3529G>A	c.(3529-3531)GCC>ACC	p.A1177T		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1177	Cytoplasmic (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AAGTGAAAACGCCCCCAAAAT	0.507													51	64					0	0	0	0	A	107022174	A	A	107022174	3	1	42	1	0	0	0	0	1	0	0	0	14996	1087	38	1	3631	1	SORCS3	10	107022174	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1048019	107022174	28512573	124	8962											
SORCS1	114815	broad.mit.edu	37	chr10	108337272	108337272	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcggagagatgagtcaccaGgttgagtagaaggggaggga	13	6	18	4	1	1	4	1	2	0	2	2	8	1	7	1	5	0	2	1	5	2	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr10:108337272G>A	uc001kym.2	-	26	3421	c.3413C>T	c.(3412-3414)CCT>CTT	p.P1138L	SORCS1_uc001kyl.2_Intron|SORCS1_uc009xxs.2_Intron|SORCS1_uc001kyn.1_3'UTR	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1138	Cytoplasmic (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGAGTCACCAGGTTGAGTAGA	0.493													5	179					0	0	0	0	A	108337272	A	A	108337272	3	1	42	1	0	0	0	0	1	0	0	0	14994	1000	35	4	166	4	SORCS1	10	108337272	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1315098	108337272	27197475	125	8963											
EBF3	253738	broad.mit.edu	37	chr10	131640456	131640456	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagttgacgcccatcatgccCgtgtgtgcagggttgttgcc	5	11	14	11	2	1	1	1	1	0	0	1	2	1	1	3	1	3	4	3	1	0	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr10:131640456C>T	uc001lki.1	-	13	1328	c.1269G>A	c.(1267-1269)ACG>ACA	p.T423T		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	432					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCATCATGCCCGTGTGTGCAG	0.602													98	167					0	0	0	0	T	131640456	T	T	131640456	2	4	42	1	0	0	0	0	0	0	0	1	4904	639	23	1		1	EBF3	10	131640456	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	23303184	131640456	3894291	126	8964											
DPYSL4	10570	broad.mit.edu	37	chr10	134004265	134004265	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgatagagtgaccgccttctGatcagaggtgggaggatcgt	9	9	15	8	3	2	4	1	2	1	2	3	7	2	6	2	3	0	0	2	3	1	2	rs137897999		TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr10:134004265G>A	uc009ybb.2	+	2	208	c.54G>A	c.(52-54)CTG>CTA	p.L18L		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	18					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		ACCGCCTTCTGATCAGAGGTG	0.438													18	84					0	0	0	0	A	134004265	A	A	134004265	2	1	42	1	0	0	0	0	0	0	0	1	4771	1277	45	2		2	DPYSL4	10	134004265	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	2363809	134004265	1530482	127	8965											
OR52E4	390081	broad.mit.edu	37	chr11	5905675	5905675	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaccattctctttgtgatCaaaactgaacatagtctaca	14	13	5	9	0	3	3	1	3	2	0	4	3	3	3	1	0	3	0	1	0	5	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:5905675C>G	uc010qzs.1	+	1	153	c.153C>G	c.(151-153)ATC>ATG	p.I51M	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTTTGTGATCAAAACTGAAC	0.428													82	290					0	0	0	0	G	5905675	G	G	5905675	3	3	42	1	0	0	0	0	1	0	0	0	11170	816	29	2	155	2	OR52E4	11	5905675	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08		5905675	129100841	128	8966											
SMPD1	6609	broad.mit.edu	37	chr11	6414465	6414465	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaattggggggttctatgctCtttccccataccccggtctc	5	13	10	13	1	3	0	0	0	3	0	5	1	4	0	4	4	2	2	4	4	3	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:6414465C>G	uc001mcw.2	+	3	1285	c.1111C>G	c.(1111-1113)CTT>GTT	p.L371V	SMPD1_uc001mcv.1_RNA|SMPD1_uc009yex.2_Intron|SMPD1_uc001mcx.2_Intron|SMPD1_uc009yew.2_Missense_Mutation_p.L370V	NM_000543	NP_000534	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid	369					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	GTTCTATGCTCTTTCCCCATA	0.493													10	58					0	0	0	0	G	6414465	G	G	6414465	3	3	42	1	0	0	0	0	1	0	0	0	14868	913	32	2	1161	2	SMPD1	11	6414465	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	508790	6414465	128592051	129	8967											
PTPMT1	114971	broad.mit.edu	37	chr11	47593175	47593175	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggacttttgtcatttcaaaGacatgatgtatggggattag	11	14	12	4	0	2	2	2	1	0	1	2	4	2	4	0	3	0	1	0	3	3	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:47593175G>C	uc001nfs.3	+	4	793	c.600G>C	c.(598-600)AAG>AAC	p.K200N	PTPMT1_uc001nfv.3_3'UTR|PTPMT1_uc009ylt.2_Missense_Mutation_p.K136N|PTPMT1_uc001nfu.3_3'UTR|NDUFS3_uc001nft.3_5'UTR	NM_175732	NP_783859	Q8WUK0	PTPM1_HUMAN	protein tyrosine phosphatase, mitochondrial 1	200					inositol phosphate dephosphorylation	mitochondrial inner membrane	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(1)	1						TCATTTCAAAGACATGATGTA	0.453													31	184					0	0	0	0	C	47593175	C	C	47593175	3	2	42	1	0	0	0	0	1	0	0	0	12841	933	33	2	719	2	PTPMT1	11	47593175	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	41178710	47593175	87413341	130	8968											
OR4A47	403253	broad.mit.edu	37	chr11	48510955	48510955	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggccaatggaggactggCttgcactattgtgtttctgc	6	13	14	8	0	1	0	0	0	1	0	1	2	1	2	1	5	2	3	1	5	2	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:48510955C>A	uc010rhx.1	+	1	611	c.611C>A	c.(610-612)GCT>GAT	p.A204D		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGAGGACTGGCTTGCACTATT	0.443													121	126					5.67207e-43	6.32856e-43	1	0	A	48510955	A	A	48510955	3	1	42	1	0	0	0	0	1	0	0	0	11096	797	28	4	613	4	OR4A47	11	48510955	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	917780	48510955	86495561	131	8969											
OR8I2	120586	broad.mit.edu	37	chr11	55861087	55861087	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttggctgctttgttcaaatgTacttttttgttggattggtg	5	21	11	4	0	1	0	1	0	0	0	1	1	1	1	0	3	2	5	0	3	2	9			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:55861087T>C	uc010rix.1	+	1	304	c.304T>C	c.(304-306)TAC>CAC	p.Y102H		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					TGTTCAAATGTACTTTTTTGT	0.398													122	146					0	0	0	0	C	55861087	C	C	55861087	3	2	42	1	0	0	0	0	1	0	0	0	11294	1638	57	5	306	5	OR8I2	11	55861087	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08	7350132	55861087	79145429	132	8970											
TNKS1BP1	85456	broad.mit.edu	37	chr11	57069409	57069409	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgaagatggcacccgagatgCccgtggctctgcaaaggccc	9	6	13	13	2	1	3	0	1	1	2	1	4	1	3	3	3	2	3	3	3	2	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:57069409C>T	uc001njr.2	-	8	5155	c.4843G>A	c.(4843-4845)GCA>ACA	p.A1615T	TNKS1BP1_uc001njp.2_Missense_Mutation_p.A187T|TNKS1BP1_uc001njq.2_Missense_Mutation_p.A188T|TNKS1BP1_uc001njs.2_Missense_Mutation_p.A1615T	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1615	Arg/Glu/Lys-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				ACCCGAGATGCCCGTGGCTCT	0.587													4	106					0	0	0	0	T	57069409	T	T	57069409	3	4	42	1	0	0	0	0	1	0	0	0	16386	739	26	4	358	4	TNKS1BP1	11	57069409	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	1208322	57069409	77937107	133	8971											
MS4A1	931	broad.mit.edu	37	chr11	60234505	60234505	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcatcgttgagaatgaatGgaaaagaacgtgctccagac	14	8	12	7	2	0	4	0	2	0	3	2	6	1	5	1	2	2	3	1	2	5	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:60234505G>A	uc001npp.2	+	7	1063	c.647G>A	c.(646-648)TGG>TAG	p.W216*	MS4A1_uc001npq.2_Nonsense_Mutation_p.W216*|MS4A1_uc009yna.2_Nonsense_Mutation_p.W216*|MS4A1_uc009ymz.2_Nonsense_Mutation_p.W203*|MS4A1_uc010rlc.1_Nonsense_Mutation_p.W49*	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	216	Cytoplasmic (Potential).				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	GAGAATGAATGGAAAAGAACG	0.433													4	151					0	0	0	0	A	60234505	A	A	60234505	4	1	42	1	0	0	0	0	0	1	0	0	9907	1357	47	4	665	4	MS4A1	11	60234505	Nonsense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	3165096	60234505	74772011	134	8972											
MTA2	9219	broad.mit.edu	37	chr11	62361854	62361854	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagaggccttccattggcaGagaaaggaacccctgcccct	10	6	10	15	0	0	2	0	0	0	2	1	4	1	3	7	3	2	1	7	3	2	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:62361854G>C	uc001ntq.1	-	17	2099	c.1718C>G	c.(1717-1719)TCT>TGT	p.S573C	TUT1_uc001nto.2_5'Flank|MTA2_uc010rlx.1_Missense_Mutation_p.S400C	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	573					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCCATTGGCAGAGAAAGGAAC	0.557													21	71					0	0	0	0	C	62361854	C	C	62361854	3	2	42	1	0	0	0	0	1	0	0	0	9962	942	33	2	296	2	MTA2	11	62361854	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	2127349	62361854	72644662	135	8973											
MTA2	9219	broad.mit.edu	37	chr11	62362037	62362037	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccccagtccccggttctggGacagctggtttctgttgatc	4	12	11	14	1	2	1	0	1	2	0	4	2	3	2	4	3	1	4	4	3	0	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:62362037G>A	uc001ntq.1	-	16	2024	c.1643C>T	c.(1642-1644)TCC>TTC	p.S548F	TUT1_uc001nto.2_5'Flank|MTA2_uc010rlx.1_Missense_Mutation_p.S375F	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	548					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CCGGTTCTGGGACAGCTGGTT	0.527													30	124					0	0	0	0	A	62362037	A	A	62362037	3	1	42	1	0	0	0	0	1	0	0	0	9962	1174	41	2	375	2	MTA2	11	62362037	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	183	62362037	72644479	136	8974											
PYGM	5837	broad.mit.edu	37	chr11	64519902	64519902	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actttggccacatcccgaatGaaagcttcatcatccacaaa	14	9	5	13	1	2	1	2	1	0	0	4	2	4	1	3	1	1	1	3	1	3	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:64519902G>A	uc001oax.3	-	13	2410	c.1593C>T	c.(1591-1593)TTC>TTT	p.F531F	PYGM_uc001oay.3_Silent_p.F443F	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	531					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CATCCCGAATGAAAGCTTCAT	0.557													14	83					0	0	0	0	A	64519902	A	A	64519902	2	1	42	1	0	0	0	0	0	0	0	1	12927	1281	45	2		2	PYGM	11	64519902	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	2157865	64519902	70486614	137	8975											
AIP	9049	broad.mit.edu	37	chr11	67257514	67257514	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccatgccctgcaggtggaGagccctggcacgtaccagca	8	5	12	16	1	0	1	0	0	0	1	0	2	0	1	5	3	5	4	5	3	1	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:67257514G>C	uc001olv.2	+	4	599	c.474G>C	c.(472-474)GAG>GAC	p.E158D		NM_003977	NP_003968	O00170	AIP_HUMAN	aryl hydrocarbon receptor interacting protein	158					protein maturation by protein folding|protein targeting to mitochondrion	nucleus	signal transducer activity|transcription coactivator activity|transcription factor binding|unfolded protein binding				0						TGCAGGTGGAGAGCCCTGGCA	0.647									Familial_Isolated_Pituitary_Adenoma_				8	4					0	0	0	0	C	67257514	C	C	67257514	3	2	42	1	0	0	0	0	1	0	0	0	435	933	33	2	488	2	AIP	11	67257514	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	2737612	67257514	67749002	138	8976											
FOLR4	390243	broad.mit.edu	37	chr11	94038883	94038883	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacgagctgctcaacatctgCatgaatgccaaacaccacaa	15	6	7	13	1	2	1	1	1	1	0	2	3	2	1	2	0	6	3	2	0	4	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:94038883C>T	uc010rud.1	+	1	81	c.81C>T	c.(79-81)TGC>TGT	p.C27C		NM_001080486	NP_001073955	A6ND01	FOLR4_HUMAN	folate receptor 4 (delta) homolog	27						extracellular region	folic acid binding|receptor activity			ovary(1)	1						TCAACATCTGCATGAATGCCA	0.587													63	65					0	0	0	0	T	94038883	T	T	94038883	2	4	42	1	0	0	0	0	0	0	0	1	6016	718	25	4		4	FOLR4	11	94038883	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	26781369	94038883	40967633	139	8977											
VPS11	55823	broad.mit.edu	37	chr11	118949887	118949887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccacactctccgtcatcaGggactacctggtccaaaaac	12	7	7	15	1	3	0	2	0	1	0	5	1	4	1	4	2	3	0	4	2	3	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr11:118949887G>A	uc010ryx.1	+	15	2357	c.2315G>A	c.(2314-2316)AGG>AAG	p.R772K	VPS11_uc010ryy.1_Missense_Mutation_p.R618K	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	772	Potential.				protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		TCCGTCATCAGGGACTACCTG	0.572													8	34					0	0	0	0	A	118949887	A	A	118949887	3	1	42	1	0	0	0	0	1	0	0	0	17256	1000	35	4	2368	4	VPS11	11	118949887	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	24911004	118949887	16056629	140	8978											
KCNA1	3736	broad.mit.edu	37	chr12	5021957	5021957	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atagcccattatagacaggtCaatatcagaactgccaattg	15	10	7	9	0	2	2	2	0	0	2	2	2	2	2	2	1	3	0	2	1	7	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:5021957C>G	uc001qnh.2	+	2	2518	c.1413C>G	c.(1411-1413)GTC>GTG	p.V471V		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	471					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ATAGACAGGTCAATATCAGAA	0.413													40	231					0	0	0	0	G	5021957	G	G	5021957	2	3	42	1	0	0	0	0	0	0	0	1	8040	813	29	2		2	KCNA1	12	5021957	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08		5021957	128829938	141	8979											
ZNF384	171017	broad.mit.edu	37	chr12	6787551	6787551	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgagacaatcatgggagccGaaatggggaaggtctgagct	12	7	15	7	1	2	2	1	2	1	1	2	6	2	4	1	4	2	1	1	4	3	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:6787551G>A	uc010sfh.1	-	6	636	c.428C>T	c.(427-429)TCG>TTG	p.S143L	ZNF384_uc001qpz.2_Missense_Mutation_p.S143L|ZNF384_uc001qqa.2_Missense_Mutation_p.S143L|ZNF384_uc001qqb.2_Missense_Mutation_p.S127L|ZNF384_uc001qqc.2_Missense_Mutation_p.S143L|ZNF384_uc001qqd.2_Intron|ZNF384_uc001qqe.2_Missense_Mutation_p.S127L|ZNF384_uc009zew.1_5'UTR	NM_001135734	NP_001129206	Q8TF68	ZN384_HUMAN	nuclear matrix transcription factor 4 isoform d	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	haematopoietic_and_lymphoid_tissue(4)|central_nervous_system(3)|kidney(1)	8						CATGGGAGCCGAAATGGGGAA	0.552			T	EWSR1|TAF15 	ALL								3	50					0	0	0	0	A	6787551	A	A	6787551	3	1	42	1	0	0	0	0	1	0	0	0	17942	1059	37	1	1329	1	ZNF384	12	6787551	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1765594	6787551	127064344	142	8980											
TM7SF3	51768	broad.mit.edu	37	chr12	27148270	27148270	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctcaggcagaaaatactgaTagacatcatactgcaacctc	15	9	6	11	0	2	3	2	1	1	2	4	3	2	3	1	1	4	2	1	1	6	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:27148270T>C	uc010sjl.1	-	5	828	c.590A>G	c.(589-591)TAT>TGT	p.Y197C		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	197						integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					AAAATACTGATAGACATCATA	0.507													49	59					0	0	0	0	C	27148270	C	C	27148270	3	2	42	1	0	0	0	0	1	0	0	0	16041	1406	49	5	1154	5	TM7SF3	12	27148270	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08	20360719	27148270	106703625	143	8981											
GPD1	2819	broad.mit.edu	37	chr12	50500210	50500210	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gttctgtgagacaaccattgGtgagagccccctggcacctg	8	9	12	12	0	1	2	0	2	1	2	1	4	1	2	4	2	2	2	4	2	1	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:50500210G>C	uc001rvz.2	+	4	532	c.499_splice	c.e4+1	p.G167_splice	GPD1_uc001rwa.2_Splice_Site_p.G144_splice	NM_005276	NP_005267	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)						glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity				0					NADH(DB00157)	ACAACCATTGGTGAGAGCCCC	0.567													15	49					0	0	0	0	C	50500210	C	C	50500210	5	2	42	1	0	0	0	0	0	0	1	0	6642	1275	44	4	514	4	GPD1	12	50500210	Splice_Site	SNP	G	TCGA-CN-4730-01A-01D-1434-08	23351940	50500210	83351685	144	8982											
KRT6C	286887	broad.mit.edu	37	chr12	52864386	52864386	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcgcaggtcgtccccatgtCtgcctgctgtgacctgcagc	4	10	12	15	2	1	1	0	1	1	0	3	1	2	1	4	1	5	3	4	1	0	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:52864386C>G	uc001sal.3	-	6	1154	c.1106G>C	c.(1105-1107)AGA>ACA	p.R369T		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	369	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GTCCCCATGTCTGCCTGCTGT	0.547													28	114					0	0	0	0	G	52864386	G	G	52864386	3	3	42	1	0	0	0	0	1	0	0	0	8521	913	32	2	604	2	KRT6C	12	52864386	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	2364176	52864386	80987509	145	8983											
KRT78	196374	broad.mit.edu	37	chr12	53240016	53240016	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcaagaagtagaggtactCtctcagagcctccagcttgc	10	10	9	12	0	3	3	2	0	1	3	5	3	4	3	2	1	4	3	2	1	4	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:53240016C>T	uc001sbc.1	-	4	785	c.721G>A	c.(721-723)GAG>AAG	p.E241K		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	241	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						TAGAGGTACTCTCTCAGAGCC	0.552													19	66					0	0	0	0	T	53240016	T	T	53240016	3	4	42	1	0	0	0	0	1	0	0	0	8530	922	32	2	865	2	KRT78	12	53240016	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	375630	53240016	80611879	146	8984											
HOXC12	3228	broad.mit.edu	37	chr12	54348555	54348559	+	5'Flank	DEL	GGGAT	-	-																															gaagggggaagttagagtgcGggatgggatggtgggggggg																								rs72049639		TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:54348555_54348559delGGGAT	uc010soq.1	+							NM_173860	NP_776272	P31275	HXC12_HUMAN	homeobox C12						multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						GTTAGAGTGCGGGATGGGATGGTGG	0.585													---	---	---								-	54348559	-	-	54348555	6	5	42	0	1	1	0	1	0	0	0	0	7350	1131	39	0		0	HOXC12	12	54348555	5'Flank	DEL	GGGAT	TCGA-CN-4730-01A-01D-1434-08	1108539	54348555	79503340	147	8985											
AVPR1A	552	broad.mit.edu	37	chr12	63541363	63541363	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaaaaacatgtatatccaggGattacagcagctattcaagg	17	9	8	7	0	1	0	1	0	0	0	2	1	2	1	1	2	4	3	1	2	8	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:63541363G>T	uc001sro.1	-	2	3007	c.1033C>A	c.(1033-1035)CCC>ACC	p.P345T		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	345	Helical; Name=7; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	TATATCCAGGGATTACAGCAG	0.388													70	109					1.34568e-36	1.48765e-36	1	0	T	63541363	T	T	63541363	3	4	42	1	0	0	0	0	1	0	0	0	1233	1174	41	2	227	2	AVPR1A	12	63541363	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	9192808	63541363	70310532	148	8986											
ACSS3	79611	broad.mit.edu	37	chr12	81471976	81471976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccttgcctgggtcctctcCggcccggggagccggtgcgg	1	7	17	16	4	1	0	0	0	1	0	3	1	2	1	6	6	3	0	6	6	0	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:81471976C>T	uc001szl.1	+	1	168	c.77C>T	c.(76-78)CCG>CTG	p.P26L	ACSS3_uc001szm.1_Missense_Mutation_p.P26L	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	26						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GGGTCCTCTCCGGCCCGGGGA	0.741													7	9					0	0	0	0	T	81471976	T	T	81471976	3	4	42	1	0	0	0	0	1	0	0	0	190	652	23	1	79	1	ACSS3	12	81471976	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	17930613	81471976	52379919	149	8987											
MED13L	23389	broad.mit.edu	37	chr12	116420250	116420250	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagcatttctgtgtagcagCgcatcaagctcaacagccaa	12	8	8	13	1	3	0	2	0	1	0	3	0	3	0	2	0	6	5	2	0	4	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:116420250C>T	uc001tvw.2	-	22	5169	c.5114G>A	c.(5113-5115)CGC>CAC	p.R1705H		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1705					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TGTGTAGCAGCGCATCAAGCT	0.438													55	82					0	0	0	0	T	116420250	T	T	116420250	3	4	42	1	0	0	0	0	1	0	0	0	9484	768	27	1	1558	1	MED13L	12	116420250	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	34948274	116420250	17431645	150	8988											
AACS	65985	broad.mit.edu	37	chr12	125621304	125621304	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttcctgaagatggcctccgGgcacgccttccagcctgact	6	9	10	16	2	0	3	0	2	0	1	3	3	3	3	6	2	1	1	6	2	1	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr12:125621304G>A	uc001uhc.2	+	17	1981	c.1775G>A	c.(1774-1776)GGG>GAG	p.G592E	AACS_uc001uhd.2_Intron|AACS_uc009zyh.2_RNA|AACS_uc009zyi.2_Missense_Mutation_p.G190E	NM_023928	NP_076417	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	592					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			ovary(1)|liver(1)|central_nervous_system(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		ATGGCCTCCGGGCACGCCTTC	0.592													72	82					0	0	0	0	A	125621304	A	A	125621304	3	1	42	1	0	0	0	0	1	0	0	0	9	1232	43	4	1841	4	AACS	12	125621304	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	9201054	125621304	8230591	151	8989											
KLHL1	57626	broad.mit.edu	37	chr13	70413285	70413285	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taatgcatgattttctaggtCagccaatatctgtgaataat	13	15	7	6	0	3	2	1	2	2	0	3	2	3	2	1	1	2	1	1	1	6	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr13:70413285C>T	uc001vip.2	-	6	2031	c.1237G>A	c.(1237-1239)GAC>AAC	p.D413N	KLHL1_uc010thm.1_Missense_Mutation_p.D352N	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	413					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TTTTCTAGGTCAGCCAATATC	0.299													64	77					0	0	0	0	T	70413285	T	T	70413285	3	4	42	1	0	0	0	0	1	0	0	0	8404	826	29	2	1033	2	KLHL1	13	70413285	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08		70413285	44756593	152	8990											
OR11H6	122748	broad.mit.edu	37	chr14	20692282	20692282	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttatcagttatggcttaTgatcggtacctggccatctg	7	17	9	8	1	2	1	1	1	1	0	3	1	2	1	2	3	1	3	2	3	4	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr14:20692282T>A	uc010tlc.1	+	1	414	c.414T>A	c.(412-414)TAT>TAA	p.Y138*		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	138	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TTATGGCTTATGATCGGTACC	0.428													136	188					0	0	0	0	A	20692282	A	A	20692282	4	1	42	1	0	0	0	0	0	1	0	0	10983	1471	51	5	416	5	OR11H6	14	20692282	Nonsense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08		20692282	86657258	153	8991											
CDH24	64403	broad.mit.edu	37	chr14	23524350	23524350	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgttgatgtcttgcactttGatgatgaactctgatggggg	7	15	13	6	1	2	5	0	5	2	0	3	5	2	5	0	2	2	2	0	2	1	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr14:23524350G>C	uc001wil.2	-	3	674	c.414C>G	c.(412-414)ATC>ATG	p.I138M	CDH24_uc010akf.2_Missense_Mutation_p.I138M|CDH24_uc001win.3_Missense_Mutation_p.I138M	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	138	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CTTGCACTTTGATGATGAACT	0.587											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	182					0	0	0	0	C	23524350	C	C	23524350	3	2	42	1	0	0	0	0	1	0	0	0	3124	1280	45	2	2089	2	CDH24	14	23524350	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	2832068	23524350	83825190	154	8992											
TJP1	7082	broad.mit.edu	37	chr15	30019044	30019044	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atcgctcgtataacttcctgGcacttttccgagattctgga	8	14	8	11	3	1	1	0	0	1	1	5	3	3	2	2	2	1	3	2	2	2	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr15:30019044G>A	uc001zcr.2	-	17	2727	c.2252C>T	c.(2251-2253)GCC>GTC	p.A751V	TJP1_uc010azl.2_Missense_Mutation_p.A739V|TJP1_uc001zcq.2_Missense_Mutation_p.A755V|TJP1_uc001zcs.2_Missense_Mutation_p.A751V	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	751	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TAACTTCCTGGCACTTTTCCG	0.363													4	202					0	0	0	0	A	30019044	A	A	30019044	3	1	42	1	0	0	0	0	1	0	0	0	15995	1203	42	4	3042	4	TJP1	15	30019044	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08		30019044	72512348	155	8993											
CCPG1	9236	broad.mit.edu	37	chr15	55652461	55652461	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttctctttatgatgccttaCaaactccttggtagaattct	9	18	5	9	0	2	2	0	1	2	1	4	2	3	2	2	1	3	1	2	1	5	7			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr15:55652461C>A	uc002acv.1	-	8	1675	c.1510G>T	c.(1510-1512)GTA>TTA	p.V504L	CCPG1_uc002acy.2_Missense_Mutation_p.V504L|CCPG1_uc002acu.1_Missense_Mutation_p.V360L|CCPG1_uc002acw.1_Missense_Mutation_p.V229L|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Missense_Mutation_p.V504L|CCPG1_uc002acz.1_Missense_Mutation_p.V504L	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	504	Lumenal (Potential).|Potential.				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		TGATGCCTTACAAACTCCTTG	0.363													184	205					4.04931e-71	4.53899e-71	1	0	A	55652461	A	A	55652461	3	1	42	1	0	0	0	0	1	0	0	0	2953	478	17	4	767	4	CCPG1	15	55652461	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	25633417	55652461	46878931	156	8994											
IQCH	64799	broad.mit.edu	37	chr15	67681204	67681204	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatctacatctgctcccatCatatgaatgacgagttagtg	11	13	7	10	1	4	2	2	2	2	0	5	3	5	2	1	0	2	2	1	0	4	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr15:67681204C>T	uc002aqo.1	+	12	1539	c.1492C>T	c.(1492-1494)CAT>TAT	p.H498Y	IQCH_uc002aqq.1_Missense_Mutation_p.H246Y|IQCH_uc002aqp.1_Missense_Mutation_p.H250Y	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	498										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		CTGCTCCCATCATATGAATGA	0.408													6	166					0	0	0	0	T	67681204	T	T	67681204	3	4	42	1	0	0	0	0	1	0	0	0	7850	826	29	2	1666	2	IQCH	15	67681204	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	12028743	67681204	34850188	157	8995											
KIF7	374654	broad.mit.edu	37	chr15	90176982	90176982	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttctgctccgtctcctcgcGaagccgcctctgcagctgtc	3	11	9	18	4	3	0	0	0	3	0	7	1	4	0	4	0	4	3	4	0	1	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr15:90176982G>A	uc002bof.2	-	12	2604	c.2527C>T	c.(2527-2529)CGC>TGC	p.R843C	KIF7_uc010upw.1_Missense_Mutation_p.R329C	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	843	Potential.				microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GTCTCCTCGCGAAGCCGCCTC	0.657													5	20					0	0	0	0	A	90176982	A	A	90176982	3	1	42	1	0	0	0	0	1	0	0	0	8348	1058	37	1	1536	1	KIF7	15	90176982	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	22495778	90176982	12354410	158	8996											
LUC7L	55692	broad.mit.edu	37	chr16	240001	240001	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcggtcccgggaagcccgacGatgtccccggctgtggctcc	4	7	14	16	5	0	0	0	0	0	0	4	3	3	1	5	4	1	2	5	4	1	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr16:240001G>A	uc002cgc.1	-	9	1051	c.940C>T	c.(940-942)CGT>TGT	p.R314C	LUC7L_uc002cga.1_Missense_Mutation_p.R314C|LUC7L_uc002cgd.1_RNA|LUC7L_uc002cge.1_Missense_Mutation_p.R314C|LUC7L_uc002cgb.1_Missense_Mutation_p.R228C	NM_201412	NP_958815	Q9NQ29	LUC7L_HUMAN	LUC7-like isoform b	314	Arg/Ser-rich.						metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				GAAGCCCGACGATGTCCCCGG	0.607													132	536					0	0	0	0	A	240001	A	A	240001	3	1	42	1	0	0	0	0	1	0	0	0	9132	1058	37	1	187	1	LUC7L	16	240001	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08		240001	90114752	159	8997											
ADCY9	115	broad.mit.edu	37	chr16	4164183	4164183	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcgaagcgaccgaacagatCgttcaggagacccaccaggg	12	4	13	12	4	1	2	1	0	0	2	3	6	1	2	3	2	2	1	3	2	2	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr16:4164183C>T	uc002cvx.2	-	2	1800	c.1261G>A	c.(1261-1263)GAT>AAT	p.D421N		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	421	Cytoplasmic (Potential).|Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						CCGAACAGATCGTTCAGGAGA	0.552													28	135					0	0	0	0	T	4164183	T	T	4164183	3	4	42	1	0	0	0	0	1	0	0	0	301	884	31	1	2840	1	ADCY9	16	4164183	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	3924182	4164183	86190570	160	8998											
NMRAL1	57407	broad.mit.edu	37	chr16	4519402	4519402	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttcctagggtttcgggtCaccactcgaaccttgaatgt	7	14	9	11	2	2	1	1	1	1	0	5	2	3	1	3	2	1	1	3	2	3	5			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr16:4519402C>T	uc002cwm.2	-	3	261	c.105G>A	c.(103-105)GTG>GTA	p.V35V	NMRAL1_uc002cwn.2_Silent_p.V35V|NMRAL1_uc002cwo.2_Silent_p.V35V|NMRAL1_uc002cwp.2_Silent_p.V71V	NM_020677	NP_065728	Q9HBL8	NMRL1_HUMAN	NmrA-like family domain containing 1	35						nucleus|perinuclear region of cytoplasm	binding			kidney(1)	1						GGTTTCGGGTCACCACTCGAA	0.562													150	328					0	0	0	0	T	4519402	T	T	4519402	2	4	42	1	0	0	0	0	0	0	0	1	10555	813	29	2		2	NMRAL1	16	4519402	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	355219	4519402	85835351	161	8999											
KIAA0556	23247	broad.mit.edu	37	chr16	27772758	27772758	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcagctgaatttcactgcctCctggggagacttgcactacc	8	11	9	13	0	2	2	2	1	0	1	3	3	3	2	3	2	4	2	3	2	2	3	rs71389807		TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr16:27772758C>G	uc002dow.2	+	19	3680	c.3656C>G	c.(3655-3657)TCC>TGC	p.S1219C		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1219										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TTCACTGCCTCCTGGGGAGAC	0.587													24	140					0	0	0	0	G	27772758	G	G	27772758	3	3	42	1	0	0	0	0	1	0	0	0	8222	855	30	2	3730	2	KIAA0556	16	27772758	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	23253356	27772758	62581995	162	9000											
GDPD3	79153	broad.mit.edu	37	chr16	30122798	30122798	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggtagtaggaaagcagcacCcagaatcctcggcttattgt	12	9	11	9	1	0	1	0	0	0	1	2	2	1	2	2	3	2	5	2	3	5	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr16:30122798C>T	uc002dwp.2	-	7	697	c.618G>A	c.(616-618)TGG>TGA	p.W206*	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Nonsense_Mutation_p.W144*|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	206	Helical; (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						AAAGCAGCACCCAGAATCCTC	0.557													98	229					0	0	0	0	T	30122798	T	T	30122798	4	4	42	1	0	0	0	0	0	1	0	0	6362	624	22	4	354	4	GDPD3	16	30122798	Nonsense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	2350040	30122798	60231955	163	9001											
C16orf78	123970	broad.mit.edu	37	chr16	49430524	49430524	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctaaagagcctcatggaGaaaagcaccgaacctaagat	18	5	9	9	1	1	3	1	0	0	3	1	5	1	3	3	1	4	2	3	1	7	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr16:49430524G>T	uc002efr.2	+	4	628	c.585G>T	c.(583-585)GAG>GAT	p.E195D		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	195										central_nervous_system(1)	1						GCCTCATGGAGAAAAGCACCG	0.547													21	32					7.45023e-12	7.90971e-12	1	0	T	49430524	T	T	49430524	3	4	42	1	0	0	0	0	1	0	0	0	1841	933	33	2	599	2	C16orf78	16	49430524	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	19307726	49430524	40924229	164	9002											
CES1	1066	broad.mit.edu	37	chr16	55846957	55846957	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccagaaggggttgactcTggggagagagcagtgcagca	10	6	17	8	0	1	3	0	1	1	2	1	5	1	4	1	4	4	4	1	4	1	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr16:55846957T>A	uc002eim.2	-	9	1051	c.943_splice	c.e9-1	p.S315_splice	CES1_uc010ccf.2_Intron|CES1_uc002eil.2_Splice_Site_p.S316_splice|CES1_uc002ein.2_Splice_Site_p.S315_splice	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor						response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	GGGTTGACTCTGGGGAGAGAG	0.542													67	101					0	0	0	0	A	55846957	A	A	55846957	5	1	42	1	0	0	0	0	0	0	1	0	3284	1594	55	5	786	5	CES1	16	55846957	Splice_Site	SNP	T	TCGA-CN-4730-01A-01D-1434-08	6416433	55846957	34507796	165	9003											
HERPUD1	9709	broad.mit.edu	37	chr16	56977167	56977167	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaagactttctttgcctctCttcttccagaaggcccccca	7	13	5	16	0	4	2	1	0	3	2	6	2	5	2	5	1	1	0	5	1	2	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr16:56977167C>G	uc002eke.1	+	8	1550	c.1141C>G	c.(1141-1143)CTT>GTT	p.L381V	HERPUD1_uc002ekf.1_Missense_Mutation_p.L380V|HERPUD1_uc002ekg.1_Missense_Mutation_p.L356V|HERPUD1_uc010cco.1_3'UTR|HERPUD1_uc010ccp.1_Missense_Mutation_p.L283V|HERPUD1_uc002ekh.1_Missense_Mutation_p.L199V	NM_014685	NP_055500	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum	381	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0						CTTTGCCTCTCTTCTTCCAGA	0.532			T	ERG	prostate								113	553					0	0	0	0	G	56977167	G	G	56977167	3	3	42	1	0	0	0	0	1	0	0	0	7102	913	32	2	1171	2	HERPUD1	16	56977167	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	1130210	56977167	33377586	166	9004											
WWOX	51741	broad.mit.edu	37	chr16	78466606	78466607	+	Frame_Shift_Del	DEL	AC	-	-																															tcatcgcagctggtgggtgtAcacactgctgtttaccttgg																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr16:78466606_78466607delAC	uc002ffk.2	+	8	1138_1139	c.1013_1014delAC	c.(1012-1014)TACfs	p.Y338fs	WWOX_uc010vnk.1_Frame_Shift_Del_p.Y225fs|WWOX_uc002ffl.2_Intron|WWOX_uc010che.2_Intron	NM_016373	NP_057457	Q9NZC7	WWOX_HUMAN	WW domain-containing oxidoreductase isoform 1	338	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity				0		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TGGTGGGTGTACACACTGCTGT	0.554													---	---	---								-	78466607	-	-	78466606	7	5	42	1	0	1	0	1	0	0	0	0	17482	391	14	0	1105	0	WWOX	16	78466606	Frame_Shift_Del	DEL	AC	TCGA-CN-4730-01A-01D-1434-08	21489439	78466606	11888147	167	9005											
ANKRD11	29123	broad.mit.edu	37	chr16	89348470	89348470	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgctcgtccctgtgatgccGcaggagctcgtccctgtgat	4	11	12	14	3	0	2	0	2	0	0	4	3	2	3	3	1	3	3	3	1	0	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr16:89348470G>A	uc002fmx.1	-	9	4941	c.4480C>T	c.(4480-4482)CGG>TGG	p.R1494W	ANKRD11_uc002fmy.1_Missense_Mutation_p.R1494W|ANKRD11_uc002fnc.1_Missense_Mutation_p.R1494W|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.R1451W	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1494	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTGTGATGCCGCAGGAGCTCG	0.537													21	68					0	0	0	0	A	89348470	A	A	89348470	3	1	42	1	0	0	0	0	1	0	0	0	639	1086	38	1	3531	1	ANKRD11	16	89348470	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	10881864	89348470	1006283	168	9006											
TAOK1	57551	broad.mit.edu	37	chr17	27837971	27837971	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatagttttctcgagtcccaGaaaagagagtataaacttcg	15	11	8	7	2	1	2	0	0	1	2	4	4	2	2	1	0	1	2	1	0	7	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:27837971G>A	uc002hdz.1	+	15	1859	c.1665G>A	c.(1663-1665)CAG>CAA	p.Q555Q	TAOK1_uc010wbe.1_Silent_p.Q555Q|TAOK1_uc010wbf.1_Silent_p.Q555Q|TAOK1_uc002heb.1_Silent_p.Q381Q	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	555	Potential.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			TCGAGTCCCAGAAAAGAGAGT	0.338													13	159					0	0	0	0	A	27837971	A	A	27837971	2	1	42	1	0	0	0	0	0	0	0	1	15613	933	33	2		2	TAOK1	17	27837971	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08		27837971	53357239	169	9007											
ERBB2	2064	broad.mit.edu	37	chr17	37881982	37881982	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgactgtgtgggagctgatGacttttggggccaaacctta	8	12	14	7	0	0	3	0	3	0	0	0	4	0	4	2	3	2	1	2	3	2	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:37881982G>A	uc002hso.2	+	23	2986	c.2748G>A	c.(2746-2748)ATG>ATA	p.M916I	ERBB2_uc002hsm.2_Missense_Mutation_p.M886I|ERBB2_uc010cwa.2_Missense_Mutation_p.M901I|ERBB2_uc002hsp.2_Missense_Mutation_p.M719I|ERBB2_uc010cwb.2_Missense_Mutation_p.M916I|ERBB2_uc010wek.1_Missense_Mutation_p.M640I	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	916	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GGGAGCTGATGACTTTTGGGG	0.602		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			7	110					0	0	0	0	A	37881982	A	A	37881982	3	1	42	1	0	0	0	0	1	0	0	0	5230	1290	45	2	2838	2	ERBB2	17	37881982	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	10044011	37881982	43313228	170	9008			3	14		3	3	1597	G		5.01667e-05
ERBB2	2064	broad.mit.edu	37	chr17	37882022	37882022	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acgatgggatcccagcccggGagatccctgacctgctggaa	9	6	13	13	2	0	2	0	1	0	1	2	6	2	4	4	3	2	1	4	3	1	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:37882022G>A	uc002hso.2	+	23	3026	c.2788G>A	c.(2788-2790)GAG>AAG	p.E930K	ERBB2_uc002hsm.2_Missense_Mutation_p.E900K|ERBB2_uc010cwa.2_Missense_Mutation_p.E915K|ERBB2_uc002hsp.2_Missense_Mutation_p.E733K|ERBB2_uc010cwb.2_Missense_Mutation_p.E930K|ERBB2_uc010wek.1_Missense_Mutation_p.E654K	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	930	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CCCAGCCCGGGAGATCCCTGA	0.592		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			6	110					0	0	0	0	A	37882022	A	A	37882022	3	1	42	1	0	0	0	0	1	0	0	0	5230	1175	41	2	2878	2	ERBB2	17	37882022	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	40	37882022	43313188	171	9009			3	14		3	3	1597	G		5.01667e-05
ERBB2	2064	broad.mit.edu	37	chr17	37883578	37883578	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gggacctgacactagggctgGagccctctgaagaggaggcc	9	5	16	11	0	1	3	0	2	1	1	1	6	1	6	3	5	1	1	3	5	2	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:37883578G>C	uc002hso.2	+	26	3428	c.3190G>C	c.(3190-3192)GAG>CAG	p.E1064Q	ERBB2_uc002hsm.2_Missense_Mutation_p.E1034Q|ERBB2_uc010cwa.2_Missense_Mutation_p.E1049Q|ERBB2_uc002hsp.2_Missense_Mutation_p.E867Q|ERBB2_uc010cwb.2_Intron|ERBB2_uc010wek.1_Missense_Mutation_p.E788Q	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	1064	Cytoplasmic (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ACTAGGGCTGGAGCCCTCTGA	0.612		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			4	105					0	0	0	0	C	37883578	C	C	37883578	3	2	42	1	0	0	0	0	1	0	0	0	5230	1175	41	2	3292	2	ERBB2	17	37883578	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1556	37883578	43311632	172	9010			3	14		3	3	1597	G		5.01667e-05
PSMD3	5709	broad.mit.edu	37	chr17	38142913	38142913	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgcctgaagtggaagcctAtctccaactcctcgtggtca	8	10	9	14	1	2	1	1	1	1	0	5	2	3	2	5	2	3	0	5	2	4	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:38142913A>G	uc002htn.1	+	3	661	c.497A>G	c.(496-498)TAT>TGT	p.Y166C	PSMD3_uc010wen.1_RNA|PSMD3_uc010weo.1_Missense_Mutation_p.Y67C	NM_002809	NP_002800	O43242	PSMD3_HUMAN	proteasome 26S non-ATPase subunit 3	166					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			ovary(1)|pancreas(1)	2	Colorectal(19;0.000442)					GTGGAAGCCTATCTCCAACTC	0.537													139	219					0	0	0	0	G	38142913	G	G	38142913	3	3	42	1	0	0	0	0	1	0	0	0	12761	449	16	5	507	5	PSMD3	17	38142913	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	259335	38142913	43052297	173	9011											
RARA	5914	broad.mit.edu	37	chr17	38487504	38487504	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagctcctgcccgacacctGggggcgggcacctcaatggg	6	5	15	15	2	1	0	1	0	0	0	2	1	2	0	4	4	2	3	4	4	1	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:38487504G>T	uc002huk.1	+	2	489	c.34G>T	c.(34-36)GGG>TGG	p.G12W	RARA_uc002hul.3_Missense_Mutation_p.G12W|RARA_uc010wfe.1_Missense_Mutation_p.G12W	NM_000964	NP_000955	P10276	RARA_HUMAN	retinoic acid receptor, alpha isoform 1	12	Modulating.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	CCCGACACCTGGGGGCGGGCA	0.662			T	PML|ZNF145|TIF1|NUMA1|NPM1	APL								23	122					3.28513e-13	3.51874e-13	1	0	T	38487504	T	T	38487504	3	4	42	1	0	0	0	0	1	0	0	0	13117	1348	47	4	36	4	RARA	17	38487504	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	344591	38487504	42707706	174	9012											
ATP6V0A1	535	broad.mit.edu	37	chr17	40665994	40665994	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccctcagcctcgctcatgCgcgtgagtacctctctccgg	4	9	11	17	4	3	1	2	1	1	0	6	1	4	1	4	2	3	2	4	2	1	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:40665994C>T	uc002hzr.2	+	20	2413	c.2246C>T	c.(2245-2247)GCG>GTG	p.A749V	ATP6V0A1_uc002hzq.2_Missense_Mutation_p.A743V|ATP6V0A1_uc002hzs.2_Missense_Mutation_p.A750V|ATP6V0A1_uc010wgj.1_Missense_Mutation_p.A706V|ATP6V0A1_uc010wgk.1_Missense_Mutation_p.A700V|ATP6V0A1_uc010cyg.2_Missense_Mutation_p.A395V|ATP6V0A1_uc010wgl.1_Missense_Mutation_p.A608V|ATP6V0A1_uc002hzt.2_Missense_Mutation_p.A33V	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	749	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		CTCGCTCATGCGCGTGAGTAC	0.582													4	235					0	0	0	0	T	40665994	T	T	40665994	3	4	42	1	0	0	0	0	1	0	0	0	1170	768	27	1	2341	1	ATP6V0A1	17	40665994	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	2178490	40665994	40529216	175	9013											
HOXB5	3215	broad.mit.edu	37	chr17	46671172	46671173	+	5'Flank	INS	-	GG	GG																															ctatgtatgcggccaaatatINSggggggggggttggaagggg																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:46671172_46671173insGG	uc002inr.2	-							NM_002147	NP_002138	P09067	HXB5_HUMAN	homeobox B5							nucleus	sequence-specific DNA binding				0						CGGCCAAATATGGGGGGGGGGT	0.47											OREG0024519	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								GG	46671173	GG	GG	46671172	6	5	42	0	1	1	1	0	0	0	0	0	7343	1479	51	0		0	HOXB5	17	46671172	5'Flank	INS	-	TCGA-CN-4730-01A-01D-1434-08	6005178	46671172	34524038	176	9014											
HLF	3131	broad.mit.edu	37	chr17	53345376	53345376	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccctcggtcatggacctcaGcagccgggcctctgcacccc	5	6	10	20	2	3	0	2	0	1	0	4	1	3	1	7	3	3	2	7	3	0	0			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:53345376G>A	uc002iug.1	+	2	905	c.380G>A	c.(379-381)AGC>AAC	p.S127N	HLF_uc010dce.1_Missense_Mutation_p.S42N|HLF_uc002iuh.2_Missense_Mutation_p.S42N|HLF_uc010wni.1_Missense_Mutation_p.A76T	NM_002126	NP_002117	Q16534	HLF_HUMAN	hepatic leukemia factor	127					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						ATGGACCTCAGCAGCCGGGCC	0.617			T	TCF3	ALL								49	205					0	0	0	0	A	53345376	A	A	53345376	3	1	42	1	0	0	0	0	1	0	0	0	7253	971	34	4	386	4	HLF	17	53345376	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	6674204	53345376	27849834	177	9015											
FTSJ3	117246	broad.mit.edu	37	chr17	61901558	61901558	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctttgtggttccagctgttGagtcctcctcatcaccttca	5	15	8	13	0	3	1	3	1	0	0	6	1	6	1	4	1	1	4	4	1	0	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:61901558G>C	uc002jbz.2	-	11	1118	c.1040C>G	c.(1039-1041)TCA>TGA	p.S347*	FTSJ3_uc002jca.2_Nonsense_Mutation_p.S347*	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	347					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						TCCAGCTGTTGAGTCCTCCTC	0.453													17	374					0	0	0	0	C	61901558	C	C	61901558	4	2	42	1	0	0	0	0	0	1	0	0	6123	1294	45	2	1543	2	FTSJ3	17	61901558	Nonsense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	8556182	61901558	19293652	178	9016											
FTSJ3	117246	broad.mit.edu	37	chr17	61902698	61902698	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctgaaagatccatagcaGaggctgatagtcacgagaac	14	7	11	9	1	1	5	1	2	0	3	2	6	2	5	1	1	3	3	1	1	4	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:61902698G>A	uc002jbz.2	-	6	577	c.499C>T	c.(499-501)CTG>TTG	p.L167L	FTSJ3_uc002jca.2_Silent_p.L167L|PSMC5_uc002jcb.2_5'Flank|PSMC5_uc010ddy.2_5'Flank|PSMC5_uc010ddz.2_5'Flank|PSMC5_uc002jcc.2_5'Flank|PSMC5_uc002jcd.2_5'Flank	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	167					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						ATCCATAGCAGAGGCTGATAG	0.532													7	113					0	0	0	0	A	61902698	A	A	61902698	2	1	42	1	0	0	0	0	0	0	0	1	6123	933	33	2		2	FTSJ3	17	61902698	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	1140	61902698	19292512	179	9017											
C17orf28	283987	broad.mit.edu	37	chr17	72955992	72955992	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgcctcctcacgatggatgCgggacaggtagttcacaaac	10	9	11	11	2	2	0	2	0	0	0	3	3	3	2	2	3	3	2	2	3	2	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr17:72955992C>T	uc002jmj.3	-	8	1141	c.992G>A	c.(991-993)CGC>CAC	p.R331H	C17orf28_uc010wrs.1_Missense_Mutation_p.R130H|C17orf28_uc002jmk.2_Missense_Mutation_p.R330H	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	331						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					ACGATGGATGCGGGACAGGTA	0.627													5	316					0	0	0	0	T	72955992	T	T	72955992	3	4	42	1	0	0	0	0	1	0	0	0	1860	768	27	1	1422	1	C17orf28	17	72955992	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	11053294	72955992	8239218	180	9018											
EPB41L3	23136	broad.mit.edu	37	chr18	5478351	5478351	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagagtttactgctagatgaTttctgagaaagtttatcgtc	11	15	10	5	1	1	4	0	2	1	3	3	6	1	4	0	0	2	3	0	0	4	6			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr18:5478351T>A	uc002kmt.1	-	3	356	c.270A>T	c.(268-270)AAA>AAT	p.K90N	EPB41L3_uc010wzh.1_Missense_Mutation_p.K90N|EPB41L3_uc002kmu.1_Missense_Mutation_p.K90N|EPB41L3_uc010dkq.1_5'UTR|EPB41L3_uc010dks.1_Missense_Mutation_p.K112N|EPB41L3_uc002kmv.1_5'UTR	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	90					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TGCTAGATGATTTCTGAGAAA	0.413													53	111					0	0	0	0	A	5478351	A	A	5478351	3	1	42	1	0	0	0	0	1	0	0	0	5178	1490	52	5	3073	5	EPB41L3	18	5478351	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08		5478351	72598897	181	9019											
LRRC30	339291	broad.mit.edu	37	chr18	7231916	7231916	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtgtagactggtgaggatCgcctggaatcccatggacaa	10	9	13	9	1	0	2	0	1	0	1	2	5	1	5	2	4	0	1	2	4	3	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr18:7231916C>T	uc010wzk.1	+	1	780	c.780C>T	c.(778-780)ATC>ATT	p.I260I		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	260										ovary(1)|liver(1)	2						TGGTGAGGATCGCCTGGAATC	0.587													184	224					0	0	0	0	T	7231916	T	T	7231916	2	4	42	1	0	0	0	0	0	0	0	1	9035	874	31	1		1	LRRC30	18	7231916	Silent	SNP	C	TCGA-CN-4730-01A-01D-1434-08	1753565	7231916	70845332	182	9020											
CDH19	28513	broad.mit.edu	37	chr18	64178822	64178822	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taccttgattatctatgattGtaaaacttgaattgttagtg	12	18	7	4	0	1	3	0	3	1	0	1	3	1	3	1	0	2	2	1	0	7	9			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr18:64178822G>C	uc002lkc.1	-	10	1697	c.1559C>G	c.(1558-1560)ACA>AGA	p.T520R	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Intron	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	520	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				ATCTATGATTGTAAAACTTGA	0.308													35	37					0	0	0	0	C	64178822	C	C	64178822	3	2	42	1	0	0	0	0	1	0	0	0	3119	1377	48	4	771	4	CDH19	18	64178822	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	56946906	64178822	13898426	183	9021											
UHRF1	29128	broad.mit.edu	37	chr19	4932906	4932907	+	Missense_Mutation	DNP	GG	AC	AC																															cggggcttctggtacgacgcGgagatctccaggaagcgcga																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr19:4932906_4932907GG>AC	uc002mbo.2	+	5	891_892	c.723_724GG>AC	c.(721-726)GCGGAG>GCACAG	p.E242Q	UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.E255Q	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	242					cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		GGTACGACGCGGAGATCTCCAG	0.653													18	50					0	0	0	0	AC	4932907	AC	AC	4932906	3	1	42	1	0	0	0	0	1	0	0	0	17035	1103	39	1	776	1	UHRF1	19	4932906	Missense_Mutation	DNP	GG	TCGA-CN-4730-01A-01D-1434-08		4932906	54196077	184	9022											
ZNF358	140467	broad.mit.edu	37	chr19	7584188	7584188	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcctgagacccgtttatgaAgagctcgactctgactccga	9	9	11	12	3	1	4	0	3	1	2	3	7	2	4	3	1	1	2	3	1	2	2			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr19:7584188A>T	uc002mgn.2	+	2	230	c.60A>T	c.(58-60)GAA>GAT	p.E20D		NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	20					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CCGTTTATGAAGAGCTCGACT	0.582													81	100					0	0	0	0	T	7584188	T	T	7584188	3	4	42	1	0	0	0	0	1	0	0	0	17934	69	3	5	62	5	ZNF358	19	7584188	Missense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	2651282	7584188	51544795	185	9023											
ZNF317	57693	broad.mit.edu	37	chr19	9271903	9271903	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgaagccacacgggggagAaaccgtacgaatgcgatcac	13	4	13	11	5	1	1	1	0	0	1	1	5	1	1	2	2	5	1	2	2	4	1			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr19:9271903A>T	uc002mku.2	+	7	1857	c.1582A>T	c.(1582-1584)AAA>TAA	p.K528*	ZNF317_uc002mkv.2_Nonsense_Mutation_p.K387*|ZNF317_uc002mkw.2_Nonsense_Mutation_p.K496*|ZNF317_uc002mkx.2_Nonsense_Mutation_p.K443*|ZNF317_uc002mky.2_Nonsense_Mutation_p.K411*	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	528					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACGGGGGAGAAACCGTACGA	0.557													14	62					0	0	0	0	T	9271903	T	T	9271903	4	4	42	1	0	0	0	0	0	1	0	0	17902	247	9	5	1604	5	ZNF317	19	9271903	Nonsense_Mutation	SNP	A	TCGA-CN-4730-01A-01D-1434-08	1687715	9271903	49857080	186	9024											
ZNF676	163223	broad.mit.edu	37	chr19	22363091	22363091	+	Silent	SNP	A	G	G																															ccacattcttcacatttgtaAggtttctctgcagcatgaat																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr19:22363091A>G	uc002nqs.1	-	3	1746	c.1428T>C	c.(1426-1428)CCT>CCC	p.P476P		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	476					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CACATTTGTAAGGTTTCTCTG	0.388													38	151					0	0	0	0	G	22363091	G	G	22363091	2	3	42	1	0	0	0	0	0	0	0	1	18150	59	3	5		5	ZNF676	19	22363091	Silent	SNP	A	TCGA-CN-4730-01A-01D-1434-08	13091188	22363091	36765892	187	9025	21	2									
ZNF676	163223	broad.mit.edu	37	chr19	22363101	22363101	+	Missense_Mutation	SNP	G	C	C																															cacatttgtaaggtttctctGcagcatgaattctcttgtgt																										TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr19:22363101G>C	uc002nqs.1	-	3	1736	c.1418C>G	c.(1417-1419)GCA>GGA	p.A473G		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	473					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AGGTTTCTCTGCAGCATGAAT	0.388													22	159					0	0	0	0	C	22363101	C	C	22363101	3	2	42	1	0	0	0	0	1	0	0	0	18150	1319	46	4	352	4	ZNF676	19	22363101	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	10	22363101	36765882	188	9026	21	2									
ZNF790	388536	broad.mit.edu	37	chr19	37309350	37309350	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatttcacaagagtgaaatGaagtgagagcttgaagaaaa	19	9	10	3	0	1	6	1	4	0	3	1	7	1	6	0	0	1	1	0	0	7	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr19:37309350G>T	uc002oew.2	-	5	2015	c.1896C>A	c.(1894-1896)TTC>TTA	p.F632L	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGAGTGAAATGAAGTGAGAGC	0.308													4	95					0.00024832	0.000256846	1	0	T	37309350	T	T	37309350	3	4	42	1	0	0	0	0	1	0	0	0	18229	1281	45	2	18	2	ZNF790	19	37309350	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	14946249	37309350	21819633	189	9027											
ZNF570	148268	broad.mit.edu	37	chr19	37974837	37974837	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagcaggatttttatgaaGaacatcaatcccagaagata	18	9	7	7	0	1	4	1	1	0	3	2	5	2	5	1	1	2	1	1	1	7	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr19:37974837G>C	uc002ogk.1	+	5	842	c.313G>C	c.(313-315)GAA>CAA	p.E105Q	ZNF570_uc010efl.1_Missense_Mutation_p.E161Q|ZNF570_uc010xtr.1_5'UTR	NM_144694	NP_653295	Q96NI8	ZN570_HUMAN	zinc finger protein 570	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTTTATGAAGAACATCAATC	0.363													36	157					0	0	0	0	C	37974837	C	C	37974837	3	2	42	1	0	0	0	0	1	0	0	0	18069	943	33	2	327	2	ZNF570	19	37974837	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	665487	37974837	21154146	190	9028											
PRPF31	26121	broad.mit.edu	37	chr19	54621975	54621975	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctgagattatgatgaagaTtgaggagtatatcagcaagc	14	11	12	4	0	1	5	1	4	0	2	1	7	1	6	0	1	3	3	0	1	5	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr19:54621975T>C	uc002qdh.2	+	3	596	c.200T>C	c.(199-201)ATT>ACT	p.I67T	TFPT_uc010yej.1_5'Flank|TFPT_uc010erd.2_5'Flank|PRPF31_uc010yek.1_Missense_Mutation_p.I67T	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	67					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ATGATGAAGATTGAGGAGTAT	0.512													40	215					0	0	0	0	C	54621975	C	C	54621975	3	2	42	1	0	0	0	0	1	0	0	0	12628	1493	52	5	206	5	PRPF31	19	54621975	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08	16647138	54621975	4507008	191	9029											
NLRP9	338321	broad.mit.edu	37	chr19	56241286	56241286	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggctggtattttccatgtcTaaaatctggaagttcttgtt	9	17	9	6	0	3	0	0	0	3	0	4	1	4	1	1	3	0	4	1	3	4	7			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr19:56241286T>G	uc002qly.2	-	3	1933	c.1905A>C	c.(1903-1905)TTA>TTC	p.L635F		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	635						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TTTCCATGTCTAAAATCTGGA	0.423													50	83					0	0	0	0	G	56241286	G	G	56241286	3	3	42	1	0	0	0	0	1	0	0	0	10538	1519	53	5	1098	5	NLRP9	19	56241286	Missense_Mutation	SNP	T	TCGA-CN-4730-01A-01D-1434-08	1619311	56241286	2887697	192	9030											
TPX2	22974	broad.mit.edu	37	chr20	30363779	30363779	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaattcaagaaacttgctCtggctggaataggtgagctt	13	11	11	6	0	2	3	1	1	1	2	2	4	2	4	0	3	3	3	0	3	6	4			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr20:30363779C>G	uc002wwp.1	+	8	1416	c.718C>G	c.(718-720)CTG>GTG	p.L240V	TPX2_uc010gdv.1_Missense_Mutation_p.L240V	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	240					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			GAAACTTGCTCTGGCTGGAAT	0.393													11	121					0	0	0	0	G	30363779	G	G	30363779	3	3	42	1	0	0	0	0	1	0	0	0	16499	912	32	2	740	2	TPX2	20	30363779	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08		30363779	32661741	193	9031											
C20orf117	140710	broad.mit.edu	37	chr20	35443638	35443638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgttccttgacagagcacCcgaggactgcatctgccttc	7	10	10	14	1	1	2	0	1	1	1	3	4	2	3	3	1	3	4	3	1	0	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr20:35443638C>T	uc002xgd.1	-	5	1820	c.1493G>A	c.(1492-1494)GGG>GAG	p.G498E	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	498											0		Myeloproliferative disorder(115;0.00874)				GACAGAGCACCCGAGGACTGC	0.602													89	155					0	0	0	0	T	35443638	T	T	35443638	3	4	42	1	0	0	0	0	1	0	0	0	2093	623	22	4	2884	4	C20orf117	20	35443638	Missense_Mutation	SNP	C	TCGA-CN-4730-01A-01D-1434-08	5079859	35443638	27581882	194	9032											
TOX2	84969	broad.mit.edu	37	chr20	42694519	42694519	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgccagcctcgcccggacGctgggctccaagtctctgct	4	8	11	18	3	1	0	0	0	1	0	4	1	2	1	5	2	3	3	5	2	1	0	rs143301359	byFrequency	TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr20:42694519G>A	uc002xlf.3	+	6	1091	c.1074G>A	c.(1072-1074)ACG>ACA	p.T358T	TOX2_uc010ggo.2_Silent_p.T376T|TOX2_uc002xle.3_Silent_p.T334T|TOX2_uc010ggp.2_Silent_p.T334T|TOX2_uc002xlg.2_Intron|TOX2_uc010zwk.1_Silent_p.T254T	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			TCGCCCGGACGCTGGGCTCCA	0.711													25	78					0	0	0	0	A	42694519	A	A	42694519	2	1	42	1	0	0	0	0	0	0	0	1	16445	1074	38	1		1	TOX2	20	42694519	Silent	SNP	G	TCGA-CN-4730-01A-01D-1434-08	7250881	42694519	20331001	195	9033											
RNF160	26046	broad.mit.edu	37	chr21	30315991	30315991	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aattggatgaattcttacttGtatagcatatgataaacagc	15	14	7	5	0	1	2	0	2	1	0	1	3	1	3	0	1	4	2	0	1	8	8			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr21:30315991G>C	uc002ymr.2	-	23	4369	c.4356C>G	c.(4354-4356)TAC>TAG	p.Y1452*		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1406							ligase activity|zinc ion binding				0						ATTCTTACTTGTATAGCATAT	0.289													35	46					0	0	0	0	C	30315991	C	C	30315991	4	2	42	1	0	0	0	0	0	1	0	0	13520	1372	48	4	1114	4	RNF160	21	30315991	Nonsense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08		30315991	17813904	196	9034											
MX1	4599	broad.mit.edu	37	chr21	42821216	42821216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggatatgctacacaccGtgacgggtgagtgctcagtt	8	11	13	9	2	1	2	1	2	0	0	1	3	1	3	1	2	3	3	1	2	2	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr21:42821216G>A	uc002yzh.2	+	16	2373	c.1426G>A	c.(1426-1428)GTG>ATG	p.V476M	MX1_uc002yzi.2_Missense_Mutation_p.V476M|MX1_uc010goq.2_Missense_Mutation_p.V476M	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	476					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GCTACACACCGTGACGGGTGA	0.468													47	52					0	0	0	0	A	42821216	A	A	42821216	3	1	42	1	0	0	0	0	1	0	0	0	10050	1145	40	1	1464	1	MX1	21	42821216	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08	12505225	42821216	5308679	197	9035											
SAMM50	25813	broad.mit.edu	37	chr22	44392241	44392241	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgtgatggcgtccagtttgGagctgggataaggttcctgt	7	13	15	6	1	0	1	0	1	0	0	2	3	2	3	2	4	1	3	2	4	1	3			TCGA-CN-4730-01A-01D-1434-08	TCGA-CN-4730-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	543bbfe3-4a11-49af-b445-303f0912bfc3	293094ab-5bd2-49ba-b9cc-04bb1b9f2709	g.chr22:44392241G>A	uc003bej.2	+	15	1585	c.1388G>A	c.(1387-1389)GGA>GAA	p.G463E	PARVB_uc003bem.2_5'Flank|SAMM50_uc011aqd.1_Missense_Mutation_p.G253E|SAMM50_uc003bek.2_Missense_Mutation_p.G268E	NM_015380	NP_056195	Q9Y512	SAM50_HUMAN	sorting and assembly machinery component 50	463					protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial sorting and assembly machinery complex	protein binding			skin(1)	1		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				GTCCAGTTTGGAGCTGGGATA	0.597													127	413					0	0	0	0	A	44392241	A	A	44392241	3	1	42	1	0	0	0	0	1	0	0	0	13894	1174	41	2	1446	2	SAMM50	22	44392241	Missense_Mutation	SNP	G	TCGA-CN-4730-01A-01D-1434-08		44392241	6912325	198	9036											
NOC2L	26155	broad.mit.edu	37	chr1	891548	891548	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggtggtggccacagctgcTcggaacgcctgtaccacttc	6	8	13	14	3	0	0	0	0	0	0	2	1	0	1	3	4	4	3	3	4	2	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr1:891548T>A	uc001abz.3	-	5	593	c.534A>T	c.(532-534)CGA>CGT	p.R178R	NOC2L_uc001aby.3_5'UTR|NOC2L_uc009vjq.2_Silent_p.R178R	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	178				R -> Q (in Ref. 1; CAB43240).		nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		CCACAGCTGCTCGGAACGCCT	0.602													77	37					0	0	0	0	A	891548	A	A	891548	2	1	43	1	0	0	0	0	0	0	0	1	10567	1538	54	5		5	NOC2L	1	891548	Silent	SNP	T	TCGA-CN-4731-01A-01D-1434-08		891548	248359073	1	9037											
ALPL	249	broad.mit.edu	37	chr1	21896804	21896804	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccttcctcctagcactccCacttcatctggaaccgcacg	7	9	6	19	2	2	0	1	0	1	0	5	1	5	1	5	1	2	2	5	1	2	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr1:21896804C>G	uc001bet.2	+	8	1056	c.799C>G	c.(799-801)CAC>GAC	p.H267D	ALPL_uc010odn.1_Missense_Mutation_p.H215D|ALPL_uc010odo.1_Missense_Mutation_p.H212D|ALPL_uc010odp.1_Missense_Mutation_p.H190D|ALPL_uc001beu.3_Missense_Mutation_p.H267D	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	267					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	CTAGCACTCCCACTTCATCTG	0.587													46	20					0	0	0	0	G	21896804	G	G	21896804	3	3	43	1	0	0	0	0	1	0	0	0	547	594	21	4	825	4	ALPL	1	21896804	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	21005256	21896804	227353817	2	9038											
PPT1	5538	broad.mit.edu	37	chr1	40542559	40542559	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagggaatggtttccttggcTtggccacttctgtaaaatcc	9	13	10	9	0	1	0	0	0	1	0	3	1	3	1	3	4	0	3	3	4	4	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr1:40542559T>A	uc001cfb.2	-	8	985	c.753A>T	c.(751-753)CAA>CAT	p.Q251H	PPT1_uc010ojf.1_Intron|PPT1_uc010ojg.1_Missense_Mutation_p.Q148H|PPT1_uc009vwa.2_RNA	NM_000310	NP_000301	P50897	PPT1_HUMAN	palmitoyl-protein thioesterase 1 isoform 1	251					brain development|cofactor metabolic process|cofactor transport|DNA fragmentation involved in apoptotic nuclear change|lysosomal lumen acidification|membrane raft organization|negative regulation of cell growth|negative regulation of neuron apoptosis|neuron development|pinocytosis|positive regulation of pinocytosis|positive regulation of receptor-mediated endocytosis|protein depalmitoylation|protein transport|receptor-mediated endocytosis|regulation of synapse structure and activity|sphingolipid catabolic process|visual perception	axon|cytosol|Golgi apparatus|lysosome|membrane fraction|membrane raft|nucleus|synaptic vesicle	palmitoyl-(protein) hydrolase activity|palmitoyl-CoA hydrolase activity			ovary(1)	1	Lung NSC(20;3.43e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1e-18)|Epithelial(16;3.6e-17)|all cancers(16;1.1e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTTCCTTGGCTTGGCCACTTC	0.463													20	200					0	0	0	0	A	40542559	A	A	40542559	3	1	43	1	0	0	0	0	1	0	0	0	12471	1606	56	5	175	5	PPT1	1	40542559	Missense_Mutation	SNP	T	TCGA-CN-4731-01A-01D-1434-08	18645755	40542559	208708062	3	9039											
TIE1	7075	broad.mit.edu	37	chr1	43783610	43783610	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaacctgctagattttctgcGgaaaagccgggtcctagaga	11	9	12	9	2	1	2	0	0	1	2	2	5	2	3	3	2	4	1	3	2	5	4			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr1:43783610G>A	uc001ciu.2	+	17	2868	c.2789G>A	c.(2788-2790)CGG>CAG	p.R930Q	TIE1_uc010oke.1_Missense_Mutation_p.R885Q|TIE1_uc009vwq.2_Missense_Mutation_p.R886Q|TIE1_uc010okg.1_Missense_Mutation_p.R575Q	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	930	Cytoplasmic (Potential).|Protein kinase.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GATTTTCTGCGGAAAAGCCGG	0.532													188	365					0	0	0	0	A	43783610	A	A	43783610	3	1	43	1	0	0	0	0	1	0	0	0	15959	1116	39	1	2855	1	TIE1	1	43783610	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	3241051	43783610	205467011	4	9040											
LRRC40	55631	broad.mit.edu	37	chr1	70614215	70614215	+	Frame_Shift_Del	DEL	T	-	-																															ctggtggaatttgtaagaggTcattattttgaaggtccaac																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr1:70614215delT	uc001der.1	-	14	1710	c.1658delA	c.(1657-1659)GACfs	p.D553fs		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	553	LRR 19.									ovary(1)	1						TTGTAAGAGGTCATTATTTTG	0.353													---	---	---								-	70614215	-	-	70614215	7	5	43	1	0	1	0	1	0	0	0	0	9048	1667	58	0	158	0	LRRC40	1	70614215	Frame_Shift_Del	DEL	T	TCGA-CN-4731-01A-01D-1434-08	26830605	70614215	178636406	5	9041											
ITGA10	8515	broad.mit.edu	37	chr1	145535006	145535006	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgggtgcccagggggcaGccatcctgctcaggtgaggg	5	7	18	11	0	1	1	1	1	0	0	2	1	2	1	3	5	3	2	3	5	0	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr1:145535006G>C	uc001eoa.2	+	15	1985	c.1909G>C	c.(1909-1911)GCC>CCC	p.A637P	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.A506P|ITGA10_uc009wiw.2_Missense_Mutation_p.A494P|ITGA10_uc010oyw.1_Missense_Mutation_p.A582P	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	637	Extracellular (Potential).|FG-GAP 7.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CCAGGGGGCAGCCATCCTGCT	0.438													49	159					0	0	0	0	C	145535006	C	C	145535006	3	2	43	1	0	0	0	0	1	0	0	0	7912	971	34	4	1967	4	ITGA10	1	145535006	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	74920791	145535006	103715615	6	9042											
CLK2	1196	broad.mit.edu	37	chr1	155240700	155240700	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgtcgcttatgctttcggctCcgatagtgttcacggtaact	6	14	10	11	5	1	0	1	0	0	0	4	1	2	0	1	2	2	5	1	2	3	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr1:155240700C>T	uc001fjy.2	-	2	359	c.69G>A	c.(67-69)CGG>CGA	p.R23R	RAG1AP1_uc010pey.1_Intron|CLK2_uc001fjw.2_Silent_p.R23R|CLK2_uc001fjx.2_5'UTR|CLK2_uc009wqm.2_Silent_p.R23R	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	23						nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCTTTCGGCTCCGATAGTGTT	0.572								Other_conserved_DNA_damage_response_genes					59	145					0	0	0	0	T	155240700	T	T	155240700	2	4	43	1	0	0	0	0	0	0	0	1	3552	842	30	2		2	CLK2	1	155240700	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	9705694	155240700	94009921	7	9043											
LRRN2	10446	broad.mit.edu	37	chr1	204587388	204587388	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taatgttgtagctgtgggttCcccgaggcaggcgggccaga	7	9	16	9	2	0	1	0	0	0	1	1	2	1	1	3	4	1	5	3	4	2	4			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr1:204587388C>A	uc001hbe.1	-	3	2121	c.1733G>T	c.(1732-1734)GGA>GTA	p.G578V	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.G578V|LRRN2_uc009xbf.1_Missense_Mutation_p.G578V|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	578	Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GCTGTGGGTTCCCCGAGGCAG	0.647													15	53					1.02788e-11	1.08344e-11	1	0	A	204587388	A	A	204587388	3	1	43	1	0	0	0	0	1	0	0	0	9085	855	30	2	412	2	LRRN2	1	204587388	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	49346688	204587388	44663233	8	9044											
OR2W3	343171	broad.mit.edu	37	chr1	248059227	248059227	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgggtggtgtggagtgcctGcttctggctgtcatggccta	3	13	16	9	0	2	0	1	0	1	0	2	1	2	1	2	5	2	2	2	5	1	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr1:248059227G>T	uc001idp.1	+	3	608	c.339G>T	c.(337-339)CTG>CTT	p.L113L	OR2W3_uc010pzb.1_Silent_p.L113L	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGGAGTGCCTGCTTCTGGCTG	0.567													49	94					1.32667e-27	1.47829e-27	1	0	T	248059227	T	T	248059227	2	4	43	1	0	0	0	0	0	0	0	1	11087	1306	46	4		4	OR2W3	1	248059227	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	43471839	248059227	1191394	9	9045											
OTOF	9381	broad.mit.edu	37	chr2	26717900	26717900	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaccacagggtccatgttCaagcccaccagctgccgggc	9	5	10	17	1	1	0	1	0	0	0	2	0	2	0	5	2	3	2	5	2	1	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:26717900C>T	uc002rhk.2	-	9	934	c.807G>A	c.(805-807)TTG>TTA	p.L269L		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	269	Cytoplasmic (Potential).|C2 1.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTCCATGTTCAAGCCCACCA	0.597													36	86					0	0	0	0	T	26717900	T	T	26717900	2	4	43	1	0	0	0	0	0	0	0	1	11357	825	29	2		2	OTOF	2	26717900	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08		26717900	216481473	10	9046											
ZFP36L2	678	broad.mit.edu	37	chr2	43452301	43452302	+	Frame_Shift_Ins	INS	-	T	T																															gctcgtccgcgttgtggatgINSaagtggcagcgcggcccata																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:43452301_43452302insT	uc002rsv.3	-	2	932_933	c.641_642insA	c.(640-642)TTCfs	p.F214fs	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	214	C3H1-type 2.				cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CGTTGTGGATGAAGTGGCAGCG	0.559													---	---	---								T	43452302	T	T	43452301	7	5	43	1	0	1	1	0	0	0	0	0	17714	1281	45	0	846	0	ZFP36L2	2	43452301	Frame_Shift_Ins	INS	-	TCGA-CN-4731-01A-01D-1434-08	16734401	43452301	199747072	11	9047											
NRXN1	9378	broad.mit.edu	37	chr2	50463980	50463980	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaactgtccactcgcaccaAtacggcttctttctgaacag	11	10	7	13	2	2	2	0	1	2	1	4	2	3	2	2	1	3	2	2	1	4	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:50463980A>T	uc010fbp.2	-	2	1195	c.388T>A	c.(388-390)TTG>ATG	p.L130M	NRXN1_uc002rxb.3_Missense_Mutation_p.L837M|NRXN1_uc010fbq.2_Missense_Mutation_p.L1205M|NRXN1_uc002rxe.3_Missense_Mutation_p.L1165M|NRXN1_uc002rxc.1_RNA	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	130	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACTCGCACCAATACGGCTTCT	0.438													27	74					0	0	0	0	T	50463980	T	T	50463980	3	4	43	1	0	0	0	0	1	0	0	0	10719	98	4	5	1054	5	NRXN1	2	50463980	Missense_Mutation	SNP	A	TCGA-CN-4731-01A-01D-1434-08	7011679	50463980	192735393	12	9048											
MAT2A	4144	broad.mit.edu	37	chr2	85769770	85769770	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggaggaggtgccttttcagGaaaggattataccaaggtcg	11	10	14	6	1	1	0	1	0	0	0	2	4	1	4	2	6	2	0	2	6	4	4			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:85769770G>A	uc002spr.2	+	7	974	c.851G>A	c.(850-852)GGA>GAA	p.G284E	MAT2A_uc010ysr.1_Missense_Mutation_p.G284E|MAT2A_uc010fgk.2_Missense_Mutation_p.G258E|MAT2A_uc010fgl.2_Missense_Mutation_p.G221E	NM_005911	NP_005902	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	284					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	GCCTTTTCAGGAAAGGATTAT	0.493													41	76					0	0	0	0	A	85769770	A	A	85769770	3	1	43	1	0	0	0	0	1	0	0	0	9383	1174	41	2	877	2	MAT2A	2	85769770	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	35305790	85769770	157429603	13	9049											
TEKT4	150483	broad.mit.edu	37	chr2	95539278	95539278	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcaggaagccgagctcaTccggaacattcaggagctgc	10	6	11	14	2	3	0	3	0	0	0	4	4	4	3	3	3	5	2	3	3	2	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:95539278T>A	uc002stw.1	+	2	605	c.512T>A	c.(511-513)ATC>AAC	p.I171N	uc002stv.1_RNA|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	171	Potential.				cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3						GCCGAGCTCATCCGGAACATT	0.607													31	63					0	0	0	0	A	95539278	A	A	95539278	3	1	43	1	0	0	0	0	1	0	0	0	15821	1435	50	5	518	5	TEKT4	2	95539278	Missense_Mutation	SNP	T	TCGA-CN-4731-01A-01D-1434-08	9769508	95539278	147660095	14	9050											
DBI	1622	broad.mit.edu	37	chr2	120128364	120128364	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaggccaagtgggatgcctGgaatgagctgaaaggtaatt	13	8	14	6	0	0	2	0	2	0	0	0	4	0	4	2	4	2	2	2	4	5	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:120128364G>A	uc002tlv.2	+	3	300	c.176G>A	c.(175-177)TGG>TAG	p.W59*	DBI_uc010yyh.1_Nonsense_Mutation_p.W76*|DBI_uc010yyi.1_Nonsense_Mutation_p.W76*|DBI_uc010yyj.1_RNA|DBI_uc010yyk.1_Nonsense_Mutation_p.W101*|DBI_uc010yyl.1_Nonsense_Mutation_p.W76*|DBI_uc010yym.1_Nonsense_Mutation_p.W69*|DBI_uc010yyn.1_Nonsense_Mutation_p.W76*|DBI_uc002tlw.2_Nonsense_Mutation_p.W76*|DBI_uc010yyo.1_RNA|DBI_uc002tlx.2_Nonsense_Mutation_p.W60*	NM_001079862	NP_001073331	P07108	ACBP_HUMAN	diazepam binding inhibitor isoform 3	59	ACB.				transport		benzodiazepine receptor binding|fatty-acyl-CoA binding				0						TGGGATGCCTGGAATGAGCTG	0.423													15	48					0	0	0	0	A	120128364	A	A	120128364	4	1	43	1	0	0	0	0	0	1	0	0	4268	1357	47	4	492	4	DBI	2	120128364	Nonsense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	24589086	120128364	123071009	15	9051											
R3HDM1	23518	broad.mit.edu	37	chr2	136418927	136418927	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgttcattacaattcacatCtaaaccaaccactgccacaa	15	10	2	14	0	3	0	2	0	1	0	3	0	3	0	3	0	4	1	3	0	6	4			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:136418927C>T	uc002tuo.2	+	18	2381	c.2011C>T	c.(2011-2013)CTA>TTA	p.L671L	R3HDM1_uc010fni.2_Silent_p.L670L|R3HDM1_uc002tup.2_Silent_p.L616L|R3HDM1_uc010zbh.1_Silent_p.L419L	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	671							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		CAATTCACATCTAAACCAACC	0.458													55	110					0	0	0	0	T	136418927	T	T	136418927	2	4	43	1	0	0	0	0	0	0	0	1	12952	912	32	2		2	R3HDM1	2	136418927	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	16290563	136418927	106780446	16	9052											
PLA2R1	22925	broad.mit.edu	37	chr2	160843742	160843742	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagggccatctctcttcataCtctgctttttcctgattttc	6	18	5	12	0	4	1	1	1	3	0	7	1	5	1	2	1	2	1	2	1	2	6			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:160843742C>A	uc002ube.1	-	12	2169	c.1962G>T	c.(1960-1962)GAG>GAT	p.E654D	PLA2R1_uc010zcp.1_Missense_Mutation_p.E654D|PLA2R1_uc002ubf.2_Missense_Mutation_p.E654D	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	654	Extracellular (Potential).				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TCTCTTCATACTCTGCTTTTT	0.502													57	112					2.12129e-23	2.34695e-23	1	0	A	160843742	A	A	160843742	3	1	43	1	0	0	0	0	1	0	0	0	12065	564	20	4	2513	4	PLA2R1	2	160843742	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	24424815	160843742	82355631	17	9053											
GRB14	2888	broad.mit.edu	37	chr2	165378524	165378524	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtagaaaaatataaaccaGatcttcttagaaaaaagtaa	22	10	5	4	0	2	3	0	0	2	3	2	3	2	3	1	0	1	2	1	0	12	7			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:165378524G>C	uc002ucl.2	-	6	1323	c.782C>G	c.(781-783)TCT>TGT	p.S261C	GRB14_uc010zcv.1_Missense_Mutation_p.S174C|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	261	PH.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						ATATAAACCAGATCTTCTTAG	0.313													40	107					0	0	0	0	C	165378524	C	C	165378524	3	2	43	1	0	0	0	0	1	0	0	0	6796	942	33	2	876	2	GRB14	2	165378524	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	4534782	165378524	77820849	18	9054											
XIRP2	129446	broad.mit.edu	37	chr2	168067394	168067394	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaggggtgactgccgcagcTtctctgctaatgtaagctgc	7	10	12	12	1	1	1	0	1	1	0	2	1	1	1	2	2	5	5	2	2	2	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:168067394T>A	uc002udx.2	+	3	730	c.712T>A	c.(712-714)TTC>ATC	p.F238I	XIRP2_uc010fpn.2_Missense_Mutation_p.F271I|XIRP2_uc010fpo.2_Missense_Mutation_p.F238I|XIRP2_uc010fpp.2_Missense_Mutation_p.F238I|XIRP2_uc002udy.2_Missense_Mutation_p.F63I|XIRP2_uc010fpq.2_Missense_Mutation_p.F16I|XIRP2_uc010fpr.2_Missense_Mutation_p.F16I	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	63					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTGCCGCAGCTTCTCTGCTAA	0.512													32	99					0	0	0	0	A	168067394	A	A	168067394	3	1	43	1	0	0	0	0	1	0	0	0	17498	1609	56	5	722	5	XIRP2	2	168067394	Missense_Mutation	SNP	T	TCGA-CN-4731-01A-01D-1434-08	2688870	168067394	75131979	19	9055											
BARD1	580	broad.mit.edu	37	chr2	215645700	215645700	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atttttgcagaccttctcagGagtcactacttcattcctgc	8	15	6	12	0	3	1	3	0	1	1	5	2	4	2	2	1	3	1	2	1	1	6			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr2:215645700G>T	uc002veu.2	-	4	1033	c.898C>A	c.(898-900)CCT>ACT	p.P300T	BARD1_uc010zjm.1_Missense_Mutation_p.P156T	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	300					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ACCTTCTCAGGAGTCACTACT	0.383									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				46	138					3.54909e-21	3.87173e-21	1	0	T	215645700	T	T	215645700	3	4	43	1	0	0	0	0	1	0	0	0	1314	1174	41	2	1467	2	BARD1	2	215645700	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	47578306	215645700	27553673	20	9056											
TGFBR2	7048	broad.mit.edu	37	chr3	30691918	30691920	+	In_Frame_Del	DEL	TGA	-	-																															ttcatgtgttcctgtagctcTgatgagtgcaatgacaacat																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:30691918_30691920delTGA	uc003ceo.2	+	3	802_804	c.420_422delTGA	c.(418-423)TCTGAT>TCT	p.D141del	TGFBR2_uc003cen.2_In_Frame_Del_p.D166del	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	141	Extracellular (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CCTGTAGCTCTGATGAGTGCAAT	0.419													---	---	---								-	30691920	-	-	30691918	7	5	43	1	0	1	0	1	0	0	0	0	15888	1567	55	0	509	0	TGFBR2	3	30691918	In_Frame_Del	DEL	TGA	TCGA-CN-4731-01A-01D-1434-08		30691918	167330512	21	9057											
CNOT10	25904	broad.mit.edu	37	chr3	32750219	32750219	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgttgaaaacagcatgttgTactataatcaagcagtcatt	15	13	7	6	0	2	1	2	1	0	0	2	1	2	1	0	0	4	5	0	0	6	6			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:32750219T>A	uc003cfc.1	+	4	592	c.337T>A	c.(337-339)TAC>AAC	p.Y113N	CNOT10_uc011axi.1_5'UTR|CNOT10_uc003cfd.1_Missense_Mutation_p.Y113N|CNOT10_uc003cfe.1_Missense_Mutation_p.Y113N|CNOT10_uc010hfv.1_RNA|CNOT10_uc011axj.1_Missense_Mutation_p.Y173N|CNOT10_uc010hfw.1_5'UTR	NM_015442	NP_056257	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	113					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			central_nervous_system(1)|skin(1)	2						CAGCATGTTGTACTATAATCA	0.348													49	47					0	0	0	0	A	32750219	A	A	32750219	3	1	43	1	0	0	0	0	1	0	0	0	3633	1638	57	5	351	5	CNOT10	3	32750219	Missense_Mutation	SNP	T	TCGA-CN-4731-01A-01D-1434-08	2058301	32750219	165272211	22	9058											
LIMD1	8994	broad.mit.edu	37	chr3	45636953	45636953	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaagtggggtgacaaaccAggagtgtcccccagcatcgg	11	5	13	12	1	0	1	0	1	0	0	2	2	1	2	4	4	2	1	4	4	2	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:45636953A>G	uc003coq.2	+	1	631	c.582A>G	c.(580-582)CCA>CCG	p.P194P		NM_014240	NP_055055	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	194					cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		GTGACAAACCAGGAGTGTCCC	0.607													48	49					0	0	0	0	G	45636953	G	G	45636953	2	3	43	1	0	0	0	0	0	0	0	1	8839	175	7	5		5	LIMD1	3	45636953	Silent	SNP	A	TCGA-CN-4731-01A-01D-1434-08	12886734	45636953	152385477	23	9059											
C3orf52	79669	broad.mit.edu	37	chr3	111812254	111812260	+	Frame_Shift_Del	DEL	AAGATGC	-	-																															tgtaataagaatgtggttggAagatgcaaactgtggatgat																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:111812254_111812260delAAGATGC	uc003dyq.3	+	2	259_265	c.186_192delAAGATGC	c.(184-192)GGAAGATGCfs	p.G62fs	C3orf52_uc011bhs.1_Frame_Shift_Del_p.G62fs|C3orf52_uc011bht.1_Frame_Shift_Del_p.G62fs	NM_024616	NP_078892	Q5BVD1	TTMP_HUMAN	TPA-induced transmembrane protein	62_64						endoplasmic reticulum membrane|integral to membrane					0						ATGTGGTTGGAAGATGCAAACTGTGGA	0.435													---	---	---								-	111812260	-	-	111812254	7	5	43	1	0	1	0	1	0	0	0	0	2242	233	9	0	192	0	C3orf52	3	111812254	Frame_Shift_Del	DEL	AAGATGC	TCGA-CN-4731-01A-01D-1434-08	66175301	111812254	86210176	24	9060											
DTX3L	151636	broad.mit.edu	37	chr3	122287599	122287599	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagggacagctgcatttcTccttctgaaccagaaaccaa	13	8	9	11	0	2	3	0	1	2	2	3	5	2	4	3	1	4	2	3	1	3	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:122287599T>A	uc003efk.2	+	3	752	c.663T>A	c.(661-663)TCT>TCA	p.S221S	DTX3L_uc010hrj.2_Intron	NM_138287	NP_612144	Q8TDB6	DTX3L_HUMAN	deltex 3-like	221					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)	4				GBM - Glioblastoma multiforme(114;0.0459)		GCTGCATTTCTCCTTCTGAAC	0.413													26	47					0	0	0	0	A	122287599	A	A	122287599	2	1	43	1	0	0	0	0	0	0	0	1	4818	1538	54	5		5	DTX3L	3	122287599	Silent	SNP	T	TCGA-CN-4731-01A-01D-1434-08	10475345	122287599	75734831	25	9061											
DNAJC13	23317	broad.mit.edu	37	chr3	132215495	132215495	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagagcatcctcttcaacCgtcataaagaaggtaagatg	15	8	8	10	1	3	3	2	0	1	3	4	3	4	3	2	1	2	2	2	1	5	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:132215495C>T	uc003eor.2	+	36	4209	c.4144C>T	c.(4144-4146)CGT>TGT	p.R1382C		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1382							heat shock protein binding			ovary(1)|breast(1)	2						CCTCTTCAACCGTCATAAAGA	0.348													22	170					0	0	0	0	T	132215495	T	T	132215495	3	4	43	1	0	0	0	0	1	0	0	0	4654	652	23	1	4282	1	DNAJC13	3	132215495	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	9927896	132215495	65806935	26	9062											
PPP2R3A	5523	broad.mit.edu	37	chr3	135797293	135797293	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taagaaaaagcaactttttgCaagtatgcctttcattagaa	16	13	6	6	0	1	2	1	0	0	2	1	2	1	2	1	0	4	3	1	0	8	6			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:135797293C>A	uc003eqv.1	+	7	3194	c.2629C>A	c.(2629-2631)CAA>AAA	p.Q877K	PPP2R3A_uc011blz.1_Missense_Mutation_p.Q141K|PPP2R3A_uc003eqw.1_Missense_Mutation_p.Q256K|PPP2R3A_uc011bma.1_RNA	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	877					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						CAACTTTTTGCAAGTATGCCT	0.254													22	80					0.00229938	0.00231421	1	0	A	135797293	A	A	135797293	3	1	43	1	0	0	0	0	1	0	0	0	12448	711	25	4	2787	4	PPP2R3A	3	135797293	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	3581798	135797293	62225137	27	9063											
ARL14	80117	broad.mit.edu	37	chr3	160395542	160395542	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctctgactgctgaggacatCaccagaatgttcaaagtgaa	13	9	10	9	0	3	4	2	3	1	1	3	5	3	5	1	1	1	3	1	1	3	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:160395542C>T	uc003fdq.2	+	1	595	c.408C>T	c.(406-408)ATC>ATT	p.I136I		NM_025047	NP_079323	Q8N4G2	ARL14_HUMAN	ADP-ribosylation factor-like 14	136					small GTPase mediated signal transduction	intracellular	GTP binding				0			Lung(72;7.02e-05)|LUSC - Lung squamous cell carcinoma(72;7.23e-05)			CTGAGGACATCACCAGAATGT	0.488													34	99					0	0	0	0	T	160395542	T	T	160395542	2	4	43	1	0	0	0	0	0	0	0	1	930	816	29	2		2	ARL14	3	160395542	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	24598249	160395542	37626888	28	9064											
PLD1	5337	broad.mit.edu	37	chr3	171406608	171406608	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attggtcaatgatgacaagcTtctcatggtgagcccacaaa	13	10	9	9	0	2	3	2	3	1	0	3	3	2	3	1	2	2	1	1	2	3	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:171406608T>C	uc003fhs.2	-	14	1513	c.1397A>G	c.(1396-1398)AAG>AGG	p.K466R	PLD1_uc003fht.2_Missense_Mutation_p.K466R	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	466	PLD phosphodiesterase 1.|Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GATGACAAGCTTCTCATGGTG	0.498													20	109					0	0	0	0	C	171406608	C	C	171406608	3	2	43	1	0	0	0	0	1	0	0	0	12100	1609	56	5	1883	5	PLD1	3	171406608	Missense_Mutation	SNP	T	TCGA-CN-4731-01A-01D-1434-08	11011066	171406608	26615822	29	9065											
NLGN1	22871	broad.mit.edu	37	chr3	173993199	173993199	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actagtgaaaacattggattCtttggtggtgaccccttaag	11	13	10	7	0	1	2	0	2	1	0	1	3	1	3	2	3	1	0	2	3	4	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:173993199C>T	uc003fio.1	+	5	1164	c.741C>T	c.(739-741)TTC>TTT	p.F247F	NLGN1_uc010hww.1_Silent_p.F287F|NLGN1_uc003fip.1_Silent_p.F247F	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	264	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			ACATTGGATTCTTTGGTGGTG	0.438													50	205					0	0	0	0	T	173993199	T	T	173993199	2	4	43	1	0	0	0	0	0	0	0	1	10515	912	32	2		2	NLGN1	3	173993199	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	2586591	173993199	24029231	30	9066											
OSTN	344901	broad.mit.edu	37	chr3	190930421	190930421	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtagatgtaacaacaacaGaggtaatggaaactagctta	18	8	9	6	0	0	2	0	0	0	2	0	3	0	3	0	2	5	4	0	2	8	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr3:190930421G>C	uc011bsn.1	+	1	100	c.100G>C	c.(100-102)GAG>CAG	p.E34Q		NM_198184	NP_937827	P61366	OSTN_HUMAN	osteocrin precursor	34					cell differentiation|multicellular organismal development|ossification		hormone activity			pancreas(1)|skin(1)	2	all_cancers(143;6.79e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000254)		AACAACAACAGAGGTAATGGA	0.343													24	61					0	0	0	0	C	190930421	C	C	190930421	3	2	43	1	0	0	0	0	1	0	0	0	11353	943	33	2	102	2	OSTN	3	190930421	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	16937222	190930421	7092009	31	9067											
ZFYVE28	57732	broad.mit.edu	37	chr4	2273119	2273119	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcagaagccacaggcctcGtctggcacccactccggggg	7	5	14	15	2	1	1	0	0	1	1	3	1	2	1	4	4	2	2	4	4	1	0	rs146945400		TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr4:2273119G>T	uc003gex.1	-	12	2770	c.2451C>A	c.(2449-2451)GAC>GAA	p.D817E	ZFYVE28_uc011bvk.1_Missense_Mutation_p.D747E|ZFYVE28_uc011bvl.1_Missense_Mutation_p.D787E|ZFYVE28_uc003gew.1_Missense_Mutation_p.D703E	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	817	FYVE-type.				negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						CACAGGCCTCGTCTGGCACCC	0.662													6	16					1.49906e-05	1.53851e-05	1	0	T	2273119	T	T	2273119	3	4	43	1	0	0	0	0	1	0	0	0	17737	1136	40	3	220	3	ZFYVE28	4	2273119	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08		2273119	188881157	32	9068											
TADA2B	93624	broad.mit.edu	37	chr4	7056307	7056307	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgaagctgaggccgctgtaCcagttcatgtcatgcaagga	10	9	12	10	1	2	2	2	2	0	0	2	3	2	3	2	2	3	5	2	2	3	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr4:7056307C>G	uc003gjw.3	+	2	940	c.789C>G	c.(787-789)TAC>TAG	p.Y263*	TADA2B_uc010idi.2_Nonsense_Mutation_p.Y188*	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0						GGCCGCTGTACCAGTTCATGT	0.527													15	56					0	0	0	0	G	7056307	G	G	7056307	4	3	43	1	0	0	0	0	0	1	0	0	15577	518	18	4	795	4	TADA2B	4	7056307	Nonsense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	4783188	7056307	184097969	33	9069											
CCKAR	886	broad.mit.edu	37	chr4	26494532	26494532	+	5'Flank	DEL	T	-	-																															ccttctttcttctttctttcTttttttttttttttctgaga																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr4:26494532delT	uc003gse.1	-							NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor						activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	tctttctttcttttttttttt	0													---	---	---								-	26494532	-	-	26494532	6	5	43	0	1	1	0	1	0	0	0	0	2893	1624	56	0		0	CCKAR	4	26494532	5'Flank	DEL	T	TCGA-CN-4731-01A-01D-1434-08	19438225	26494532	164659744	34	9070											
PHOX2B	8929	broad.mit.edu	37	chr4	41749528	41749528	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcttctcgttgaggccgccGtggtccgtgaagagtttgta	5	12	14	10	5	1	3	0	2	1	1	3	3	2	3	3	2	0	4	3	2	2	4			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr4:41749528G>A	uc003gwf.3	-	2	627	c.267C>T	c.(265-267)CAC>CAT	p.H89H		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	89					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						TGAGGCCGCCGTGGTCCGTGA	0.577			Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				53	147					0	0	0	0	A	41749528	A	A	41749528	2	1	43	1	0	0	0	0	0	0	0	1	11914	1136	40	1		1	PHOX2B	4	41749528	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	15254996	41749528	149404748	35	9071											
TXK	7294	broad.mit.edu	37	chr4	48096216	48096216	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatgttttatggcagcctccGtacttctacaatcaagaaaa	14	12	6	9	1	2	1	1	0	1	1	3	1	3	1	2	1	3	3	2	1	8	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr4:48096216G>T	uc003gxx.3	-	8	673	c.587C>A	c.(586-588)ACG>AAG	p.T196K	TXK_uc003gxy.1_Missense_Mutation_p.T196K	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	196	SH2.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GGCAGCCTCCGTACTTCTACA	0.373													20	63					1.01871e-10	1.06657e-10	1	0	T	48096216	T	T	48096216	3	4	43	1	0	0	0	0	1	0	0	0	16854	1145	40	3	1028	3	TXK	4	48096216	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	6346688	48096216	143058060	36	9072											
ANK2	287	broad.mit.edu	37	chr4	114264272	114264272	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtttttttgccttcaaaGaaaatagacttcctctattt	11	18	4	8	0	3	2	2	0	1	2	4	2	4	2	2	0	1	1	2	0	5	8			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr4:114264272G>T	uc003ibe.3	+	34	4322	c.4222G>T	c.(4222-4224)GAA>TAA	p.E1408*	ANK2_uc003ibd.3_Nonsense_Mutation_p.E1399*|ANK2_uc003ibf.3_Nonsense_Mutation_p.E1408*|ANK2_uc011cgc.1_Nonsense_Mutation_p.E584*|ANK2_uc003ibg.3_Nonsense_Mutation_p.E403*|ANK2_uc003ibh.3_Nonsense_Mutation_p.E82*|ANK2_uc011cgb.1_Nonsense_Mutation_p.E1423*	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1375					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGCCTTCAAAGAAAATAGACT	0.338													42	91					1.57019e-19	1.68931e-19	1	0	T	114264272	T	T	114264272	4	4	43	1	0	0	0	0	0	1	0	0	621	943	33	2	4421	2	ANK2	4	114264272	Nonsense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	66168056	114264272	76890004	37	9073											
ADAD1	132612	broad.mit.edu	37	chr4	123305081	123305081	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttagctcttgatgagcttctAcaactggatgaacctgaacc	11	12	8	10	0	2	4	0	4	2	0	2	5	2	5	2	1	6	2	2	1	5	4			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr4:123305081A>G	uc003ieo.2	+	5	721	c.489A>G	c.(487-489)CTA>CTG	p.L163L	ADAD1_uc003iep.2_Silent_p.L163L|ADAD1_uc003ieq.2_Silent_p.L145L	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	163	DRBM.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						ATGAGCTTCTACAACTGGATG	0.358													28	84					0	0	0	0	G	123305081	G	G	123305081	2	3	43	1	0	0	0	0	0	0	0	1	231	378	14	5		5	ADAD1	4	123305081	Silent	SNP	A	TCGA-CN-4731-01A-01D-1434-08	9040809	123305081	67849195	38	9074											
FAT1	2195	broad.mit.edu	37	chr4	187549454	187549454	+	Frame_Shift_Del	DEL	G	-	-																															accacggggcgtggtcattcGtgtcgctgacattgaccaca																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr4:187549454delG	uc003izf.2	-	9	4852	c.4664delC	c.(4663-4665)ACGfs	p.T1555fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1555	Extracellular (Potential).|Cadherin 13.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTGGTCATTCGTGTCGCTGAC	0.502										HNSCC(5;0.00058)			---	---	---								-	187549454	-	-	187549454	7	5	43	1	0	1	0	1	0	0	0	0	5721	1145	40	0	9178	0	FAT1	4	187549454	Frame_Shift_Del	DEL	G	TCGA-CN-4731-01A-01D-1434-08	64244373	187549454	3604822	39	9075											
FAT1	2195	broad.mit.edu	37	chr4	187557332	187557333	+	Frame_Shift_Ins	INS	-	A	A																															ttgggcttggagatccattcINSaatatggagtctggtggttg																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr4:187557332_187557333insA	uc003izf.2	-	6	4217_4218	c.4029_4030insT	c.(4027-4032)ATTGAAfs	p.I1343fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1343_1344	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GAGATCCATTCAATATGGAGTC	0.441										HNSCC(5;0.00058)			---	---	---								A	187557333	A	A	187557332	7	5	43	1	0	1	1	0	0	0	0	0	5721	835	29	0	9824	0	FAT1	4	187557332	Frame_Shift_Ins	INS	-	TCGA-CN-4731-01A-01D-1434-08	7878	187557332	3596944	40	9076											
ZDHHC11	79844	broad.mit.edu	37	chr5	801279	801279	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctgttgtttcttgttgcagCctgtttgcaatattcagaaa	8	18	8	7	0	3	1	1	0	2	1	3	1	3	1	1	0	3	6	1	0	3	7			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr5:801279C>T	uc011cma.1	-	12	1566	c.1182G>A	c.(1180-1182)GGG>GGA	p.G394G	ZDHHC11_uc010itc.2_RNA|ZDHHC11_uc003jbj.2_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	394						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			CTTGTTGCAGCCTGTTTGCAA	0.383													33	174					0	0	0	0	T	801279	T	T	801279	2	4	43	1	0	0	0	0	0	0	0	1	17668	753	26	4		4	ZDHHC11	5	801279	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08		801279	180113981	41	9077											
IRX2	153572	broad.mit.edu	37	chr5	2749083	2749083	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcccgattcgcacagggggtCcccggcgcggcacggaagct	6	4	16	15	6	0	0	0	0	0	0	2	2	1	1	3	5	1	3	3	5	1	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr5:2749083C>T	uc003jda.2	-	3	981	c.739G>A	c.(739-741)GAC>AAC	p.D247N	IRX2_uc003jdb.2_Missense_Mutation_p.D247N	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	247						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		CACAGGGGGTCCCCGGCGCGG	0.706													22	118					0	0	0	0	T	2749083	T	T	2749083	3	4	43	1	0	0	0	0	1	0	0	0	7883	855	30	2	684	2	IRX2	5	2749083	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	1947804	2749083	178166177	42	9078											
FAM134B	54463	broad.mit.edu	37	chr5	16616784	16616784	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacagcaggttggcagcgacGaagccgagcaggctccgcag	11	3	15	12	4	0	0	0	0	0	0	1	3	1	0	2	3	5	6	2	3	2	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr5:16616784G>A	uc003jfs.2	-	1	335	c.297C>T	c.(295-297)TTC>TTT	p.F99F		NM_001034850	NP_001030022	Q9H6L5	F134B_HUMAN	hypothetical protein LOC54463 isoform 1	99	Helical; (Potential).				sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3						TGGCAGCGACGAAGCCGAGCA	0.592													7	31					0	0	0	0	A	16616784	A	A	16616784	2	1	43	1	0	0	0	0	0	0	0	1	5474	1049	37	1		1	FAM134B	5	16616784	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	13867701	16616784	164298476	43	9079											
ADAMTS12	81792	broad.mit.edu	37	chr5	33576201	33576201	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagtgtgcagagccgtggccGtttgtgagctgcttgtaatt	6	13	14	8	2	0	2	0	1	0	1	0	2	0	2	2	1	4	5	2	1	1	4	rs141717162		TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr5:33576201G>A	uc003jia.1	-	19	4093	c.3930C>T	c.(3928-3930)AAC>AAT	p.N1310N	ADAMTS12_uc010iuq.1_Silent_p.N1225N	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1310	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGCCGTGGCCGTTTGTGAGCT	0.468										HNSCC(64;0.19)			77	396					0	0	0	0	A	33576201	A	A	33576201	2	1	43	1	0	0	0	0	0	0	0	1	257	1136	40	1		1	ADAMTS12	5	33576201	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	16959417	33576201	147339059	44	9080											
RAPGEF6	51735	broad.mit.edu	37	chr5	130840396	130840396	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccataacaatttctccctCttcctcaactttatgggtat	10	16	3	12	0	3	0	1	0	2	0	5	0	4	0	3	1	3	1	3	1	6	7			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr5:130840396C>T	uc003kvn.1	-	11	1383	c.1177G>A	c.(1177-1179)GAG>AAG	p.E393K	RAPGEF6_uc003kvp.1_Missense_Mutation_p.E443K|RAPGEF6_uc003kvo.1_Missense_Mutation_p.E393K|RAPGEF6_uc010jdi.1_Missense_Mutation_p.E393K|RAPGEF6_uc010jdj.1_Missense_Mutation_p.E393K|RAPGEF6_uc003kvq.2_Missense_Mutation_p.E110K|RAPGEF6_uc003kvr.2_Missense_Mutation_p.E393K|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.E393K	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	393	cNMP.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		ATTTCTCCCTCTTCCTCAACT	0.413													35	87					0	0	0	0	T	130840396	T	T	130840396	3	4	43	1	0	0	0	0	1	0	0	0	13113	922	32	2	4186	2	RAPGEF6	5	130840396	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	97264195	130840396	50074864	45	9081											
GRXCR2	643226	broad.mit.edu	37	chr5	145252398	145252398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgagggtattcctcctttGgtgactctaattcctgccca	6	15	9	11	0	1	2	0	2	1	0	4	2	4	2	4	2	1	1	4	2	2	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr5:145252398G>A	uc003lns.1	-	1	134	c.134C>T	c.(133-135)CCA>CTA	p.P45L		NM_001080516	NP_001073985	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	45											0						TTCCTCCTTTGGTGACTCTAA	0.498													74	108					0	0	0	0	A	145252398	A	A	145252398	3	1	43	1	0	0	0	0	1	0	0	0	6852	1348	47	4	624	4	GRXCR2	5	145252398	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	14412002	145252398	35662862	46	9082											
FAT2	2196	broad.mit.edu	37	chr5	150924382	150924382	+	Frame_Shift_Del	DEL	A	-	-																															aattcatatgtaacagccccAtttgtccccaagtcctcatc																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr5:150924382delA	uc003lue.3	-	9	6319	c.6306delT	c.(6304-6306)AATfs	p.N2102fs	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2102	Extracellular (Potential).|Cadherin 18.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TAACAGCCCCATTTGTCCCCA	0.428													---	---	---								-	150924382	-	-	150924382	7	5	43	1	0	1	0	1	0	0	0	0	5722	214	8	0	6803	0	FAT2	5	150924382	Frame_Shift_Del	DEL	A	TCGA-CN-4731-01A-01D-1434-08	5671984	150924382	29990878	47	9083											
HIST1H1C	3006	broad.mit.edu	37	chr6	26056369	26056369	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccagaagcaccggtgcctttCgtttgcaccagagtgccctt	7	10	10	14	2	0	2	0	0	0	2	1	2	0	2	5	1	4	3	5	1	1	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr6:26056369C>G	uc003nfw.2	-	1	331	c.288G>C	c.(286-288)ACG>ACC	p.T96T		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	96	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						CGGTGCCTTTCGTTTGCACCA	0.532													50	241					0	0	0	0	G	26056369	G	G	26056369	2	3	43	1	0	0	0	0	0	0	0	1	7163	871	31	3		3	HIST1H1C	6	26056369	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08		26056369	145058698	48	9084											
PGBD1	84547	broad.mit.edu	37	chr6	28269361	28269361	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtgtggtacaaccacacAgggttatctggtttggtttg	7	15	13	6	0	1	0	0	0	1	0	1	0	1	0	1	5	2	4	1	5	3	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr6:28269361A>T	uc003nky.2	+	7	2100	c.1730A>T	c.(1729-1731)CAG>CTG	p.Q577L	PGBD1_uc003nkz.2_Missense_Mutation_p.Q577L	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	577					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						ACAACCACACAGGGTTATCTG	0.388													87	136					0	0	0	0	T	28269361	T	T	28269361	3	4	43	1	0	0	0	0	1	0	0	0	11835	188	7	5	1752	5	PGBD1	6	28269361	Missense_Mutation	SNP	A	TCGA-CN-4731-01A-01D-1434-08	2212992	28269361	142845706	49	9085											
TULP1	7287	broad.mit.edu	37	chr6	35466208	35466208	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgaaggcgtcctccgccaCgcggccgaactgcagcacga	8	4	14	15	6	0	1	0	1	0	0	2	3	2	1	4	3	3	2	4	3	2	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr6:35466208C>T	uc003okv.3	-	15	1537	c.1525G>A	c.(1525-1527)GTG>ATG	p.V509M	TEAD3_uc003oku.3_5'Flank|TEAD3_uc010jvx.2_5'Flank|TULP1_uc003okw.3_Missense_Mutation_p.V456M	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	509					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						TCCTCCGCCACGCGGCCGAAC	0.667													10	40					0	0	0	0	T	35466208	T	T	35466208	3	4	43	1	0	0	0	0	1	0	0	0	16841	536	19	1	107	1	TULP1	6	35466208	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	7196847	35466208	135648859	50	9086											
AARS2	57505	broad.mit.edu	37	chr6	44275034	44275034	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcagagatgcagacactgAgtgtgcggatgtggtcagcc	10	8	14	9	1	2	3	2	1	0	2	2	5	2	4	1	2	3	1	1	2	0	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr6:44275034A>T	uc010jza.1	-	6	995	c.992T>A	c.(991-993)CTC>CAC	p.L331H	SPATS1_uc003oxg.2_RNA|TMEM151B_uc003oxf.2_3'UTR	NM_020745	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	331					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			ovary(1)	1	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	GCAGACACTGAGTGTGCGGAT	0.642													11	23					0	0	0	0	T	44275034	T	T	44275034	3	4	43	1	0	0	0	0	1	0	0	0	20	304	11	5	2033	5	AARS2	6	44275034	Missense_Mutation	SNP	A	TCGA-CN-4731-01A-01D-1434-08	8808826	44275034	126840033	51	9087											
TINAG	27283	broad.mit.edu	37	chr6	54254654	54254654	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcaggattcttcgaggagtAaatgagtccgacattgaaaa	14	11	10	6	2	2	2	1	2	1	0	4	6	3	4	1	2	0	1	1	2	4	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr6:54254654A>G	uc003pcj.2	+	11	1508	c.1362A>G	c.(1360-1362)GTA>GTG	p.V454V	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	454					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TTCGAGGAGTAAATGAGTCCG	0.403													7	274					0	0	0	0	G	54254654	G	G	54254654	2	3	43	1	0	0	0	0	0	0	0	1	15987	349	13	5		5	TINAG	6	54254654	Silent	SNP	A	TCGA-CN-4731-01A-01D-1434-08	9979620	54254654	116860413	52	9088											
DST	667	broad.mit.edu	37	chr6	56394429	56394429	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgacttttctcttgaatCtcaatgtaccatacttgaga	10	16	6	9	0	2	3	1	3	2	1	4	4	2	3	1	0	2	1	1	0	4	6			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr6:56394429C>T	uc003pdf.2	-	60	11083	c.11055G>A	c.(11053-11055)GAG>GAA	p.E3685E	DST_uc003pcz.3_Silent_p.E3507E|DST_uc011dxj.1_Silent_p.E3536E|DST_uc011dxk.1_Silent_p.E3547E|DST_uc003pcy.3_Silent_p.E3181E	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5593	Spectrin 9.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCTCTTGAATCTCAATGTACC	0.433													74	215					0	0	0	0	T	56394429	T	T	56394429	2	4	43	1	0	0	0	0	0	0	0	1	4805	912	32	2		2	DST	6	56394429	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	2139775	56394429	114720638	53	9089											
DDX43	55510	broad.mit.edu	37	chr6	74116174	74116174	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agacattgtgttatttaatgCctggatttattcatctggtc	9	18	8	6	0	2	1	1	0	1	1	3	2	2	2	1	2	1	1	1	2	3	7			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr6:74116174C>T	uc003pgw.2	+	7	1239	c.895C>T	c.(895-897)CCT>TCT	p.P299S	DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	299	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						TTATTTAATGCCTGGATTTAT	0.378													33	87					0	0	0	0	T	74116174	T	T	74116174	3	4	43	1	0	0	0	0	1	0	0	0	4380	739	26	4	921	4	DDX43	6	74116174	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	17721745	74116174	96998893	54	9090											
LAMA2	3908	broad.mit.edu	37	chr6	129674411	129674411	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgtgccctgtgaccctgtCacaggattctgcacgtgccg	5	10	11	15	2	2	1	1	1	1	0	2	2	2	2	4	1	3	1	4	1	0	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr6:129674411C>T	uc003qbn.2	+	32	4731	c.4626C>T	c.(4624-4626)GTC>GTT	p.V1542V	LAMA2_uc003qbo.2_Silent_p.V1542V	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1542	Laminin EGF-like 17.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GTGACCCTGTCACAGGATTCT	0.597													60	73					0	0	0	0	T	129674411	T	T	129674411	2	4	43	1	0	0	0	0	0	0	0	1	8646	813	29	2		2	LAMA2	6	129674411	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	55558237	129674411	41440656	55	9091											
CRHR2	1395	broad.mit.edu	37	chr7	30704714	30704714	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctcgtgcacttcatggtcaAcgagctgcagcaggaaccac	10	8	10	13	2	3	0	2	0	1	0	4	2	3	1	1	2	6	4	1	2	2	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr7:30704714A>G	uc003tbn.2	-	5	759	c.515T>C	c.(514-516)GTT>GCT	p.V172A	CRHR2_uc010kvw.1_Missense_Mutation_p.V172A|CRHR2_uc010kvx.1_Missense_Mutation_p.V171A|CRHR2_uc010kvy.1_Missense_Mutation_p.V8A|CRHR2_uc003tbo.2_Missense_Mutation_p.V158A|CRHR2_uc003tbp.2_Missense_Mutation_p.V199A	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	172	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						TTCATGGTCAACGAGCTGCAG	0.562													4	99					0	0	0	0	G	30704714	G	G	30704714	3	3	43	1	0	0	0	0	1	0	0	0	3887	43	2	5	752	5	CRHR2	7	30704714	Missense_Mutation	SNP	A	TCGA-CN-4731-01A-01D-1434-08		30704714	128433949	56	9092											
GNAT3	346562	broad.mit.edu	37	chr7	80091853	80091853	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgaggaccatgtcataggCactaagtgcagcacaaaata	16	6	9	10	1	1	0	1	0	0	0	1	2	1	1	1	2	2	3	1	2	5	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr7:80091853C>A	uc011kgu.1	-	6	685	c.685G>T	c.(685-687)GCC>TCC	p.A229S	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	229					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						ATGTCATAGGCACTAAGTGCA	0.398													8	112					2.17888e-05	2.2216e-05	1	0	A	80091853	A	A	80091853	3	1	43	1	0	0	0	0	1	0	0	0	6550	710	25	4	389	4	GNAT3	7	80091853	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	49387139	80091853	79046810	57	9093											
PIP	5304	broad.mit.edu	37	chr7	142836666	142836666	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggaattaggcatctgcccTgatgatgctgctgtaatccc	8	11	11	11	1	1	2	0	2	1	0	2	3	2	3	2	2	3	4	2	2	3	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr7:142836666T>G	uc003wcf.1	+	4	408	c.372T>G	c.(370-372)CCT>CCG	p.P124P		NM_002652	NP_002643	P12273	PIP_HUMAN	prolactin-induced protein precursor	124						extracellular region	actin binding			ovary(1)	1	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		GCATCTGCCCTGATGATGCTG	0.468													104	150					0	0	0	0	G	142836666	G	G	142836666	2	3	43	1	0	0	0	0	0	0	0	1	11990	1567	55	5		5	PIP	7	142836666	Silent	SNP	T	TCGA-CN-4731-01A-01D-1434-08	62744813	142836666	16301997	58	9094											
HGSNAT	138050	broad.mit.edu	37	chr8	43046738	43046738	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccagtccctgggtgccctaCgtaagcgaacccctgggggt	6	7	14	14	2	0	0	0	0	0	0	1	1	1	0	5	3	4	1	5	3	3	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr8:43046738C>A	uc003xpx.3	+	12	1298	c.1250C>A	c.(1249-1251)ACT>AAT	p.T417N		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	445	Lumenal, vesicle (Potential).				lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			GGGTGCCCTACGTAAGCGAAC	0.597													38	174					5.78141e-17	6.1774e-17	1	0	A	43046738	A	A	43046738	3	1	43	1	0	0	0	0	1	0	0	0	7127	550	19	3	1296	3	HGSNAT	8	43046738	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08		43046738	103317284	59	9095											
MCM4	4173	broad.mit.edu	37	chr8	48874211	48874211	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctgcgcaggacgtgctgtTttccagccctccccaaatgc	6	10	10	15	2	0	0	0	0	0	0	2	1	2	1	4	1	5	4	4	1	1	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr8:48874211T>C	uc003xqk.1	+	3	301	c.206T>C	c.(205-207)TTT>TCT	p.F69S	PRKDC_uc003xqi.2_5'Flank|PRKDC_uc003xqj.2_5'Flank|PRKDC_uc011ldh.1_5'Flank|MCM4_uc003xql.1_Missense_Mutation_p.F69S|MCM4_uc011ldi.1_Missense_Mutation_p.F69S|MCM4_uc010lxw.1_Intron	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	69					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				GACGTGCTGTTTTCCAGCCCT	0.557													18	174					0	0	0	0	C	48874211	C	C	48874211	3	2	43	1	0	0	0	0	1	0	0	0	9442	1841	64	5	212	5	MCM4	8	48874211	Missense_Mutation	SNP	T	TCGA-CN-4731-01A-01D-1434-08	5827473	48874211	97489811	60	9096											
RP1	6101	broad.mit.edu	37	chr8	55539813	55539813	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattctgcaatatgtaattCatccactaatctccttctag	11	16	3	11	0	5	0	2	0	3	0	7	0	6	0	2	0	1	2	2	0	5	7			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr8:55539813C>A	uc003xsd.1	+	4	3519	c.3371C>A	c.(3370-3372)TCA>TAA	p.S1124*	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1124					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATATGTAATTCATCCACTAAT	0.418													39	92					9.8876e-21	1.07116e-20	1	0	A	55539813	A	A	55539813	4	1	43	1	0	0	0	0	0	1	0	0	13597	838	29	2	3381	2	RP1	8	55539813	Nonsense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	6665602	55539813	90824209	61	9097											
VPS13B	157680	broad.mit.edu	37	chr8	100533240	100533240	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttaggaaagatatttaccagTaagtttattttcttatgtcc	12	18	6	5	0	1	1	0	0	1	1	2	2	2	2	2	1	1	2	2	1	7	10			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr8:100533240T>A	uc003yiv.2	+	30	4931	c.4820_splice	c.e30+2	p.Q1607_splice	VPS13B_uc003yiw.2_Splice_Site_p.Q1582_splice	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5						protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TATTTACCAGTAAGTTTATTT	0.393													70	100					0	0	0	0	A	100533240	A	A	100533240	5	1	43	1	0	0	0	0	0	0	1	0	17258	1652	57	5	5130	5	VPS13B	8	100533240	Splice_Site	SNP	T	TCGA-CN-4731-01A-01D-1434-08	44993427	100533240	45830782	62	9098											
MED30	90390	broad.mit.edu	37	chr8	118552148	118552148	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaacagaagaatcaacagctGaaacaaattatggatcaatt	21	8	6	6	0	2	3	2	1	0	2	2	4	2	4	0	1	4	1	0	1	8	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr8:118552148G>A	uc003yoj.2	+	4	619	c.468G>A	c.(466-468)CTG>CTA	p.L156L	MED30_uc011lib.1_Silent_p.L121L	NM_080651	NP_542382	Q96HR3	MED30_HUMAN	TRAP/Mediator complex component TRAP25	156	Potential.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding				0	all_cancers(13;3.41e-25)|Lung NSC(37;3.02e-05)|Ovarian(258;0.00163)		STAD - Stomach adenocarcinoma(47;0.0266)			ATCAACAGCTGAAACAAATTA	0.303													18	40					0	0	0	0	A	118552148	A	A	118552148	2	1	43	1	0	0	0	0	0	0	0	1	9501	1277	45	2		2	MED30	8	118552148	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	18018908	118552148	27811874	63	9099											
RUSC2	9853	broad.mit.edu	37	chr9	35555657	35555657	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgagcagagagcctggcccGgggaggtggtgagggcagca	8	3	20	10	2	0	2	0	1	0	1	0	5	0	3	3	6	3	3	3	6	0	0	rs140042742	byFrequency	TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr9:35555657G>A	uc003zww.2	+	3	2870	c.2615G>A	c.(2614-2616)CGG>CAG	p.R872Q	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.R872Q	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	872						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			AGCCTGGCCCGGGGAGGTGGT	0.632													33	58					0	0	0	0	A	35555657	A	A	35555657	3	1	43	1	0	0	0	0	1	0	0	0	13816	1116	39	1	2621	1	RUSC2	9	35555657	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08		35555657	105657774	64	9100											
GDA	9615	broad.mit.edu	37	chr9	74863197	74863197	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttctttcaggagatgatcGaaatattgaagaggtttatg	12	16	10	3	1	2	4	1	2	1	2	3	6	2	4	0	2	0	1	0	2	4	7			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr9:74863197G>A	uc004aiq.2	+	14	1487	c.1304G>A	c.(1303-1305)CGA>CAA	p.R435Q	GDA_uc011lse.1_Missense_Mutation_p.R361Q|GDA_uc011lsf.1_Missense_Mutation_p.R361Q|GDA_uc004air.2_Missense_Mutation_p.R435Q|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Missense_Mutation_p.R357Q	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	435					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GGAGATGATCGAAATATTGAA	0.403													52	124					0	0	0	0	A	74863197	A	A	74863197	3	1	43	1	0	0	0	0	1	0	0	0	6342	1058	37	1	1358	1	GDA	9	74863197	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	39307540	74863197	66350234	65	9101											
C9orf117	286207	broad.mit.edu	37	chr9	130475482	130475482	+	Frame_Shift_Del	DEL	T	-	-																															ttccgggcacacagcagcccTgaggtgagggtgccaggggc																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr9:130475482delT	uc004brn.1	+	8	1528	c.1488delT	c.(1486-1488)CCTfs	p.P496fs	PTRH1_uc004brm.2_Intron|C9orf117_uc010mxl.1_RNA|TTC16_uc004brq.1_5'Flank|TTC16_uc011mai.1_5'Flank	NM_001012502	NP_001012520	Q5JU67	CI117_HUMAN	hypothetical protein LOC286207	496											0						ACAGCAGCCCTGAGGTGAGGG	0.408													---	---	---								-	130475482	-	-	130475482	7	5	43	1	0	1	0	1	0	0	0	0	2463	1567	55	0	1518	0	C9orf117	9	130475482	Frame_Shift_Del	DEL	T	TCGA-CN-4731-01A-01D-1434-08	55612285	130475482	10737949	66	9102											
SETX	23064	broad.mit.edu	37	chr9	135153533	135153533	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggatgcatcctgtactgaaCagtgagctgtagaatgggca	11	10	13	7	0	0	3	0	2	0	1	1	4	1	4	1	2	4	5	1	2	4	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr9:135153533C>G	uc004cbk.2	-	21	6949	c.6766G>C	c.(6766-6768)GTT>CTT	p.V2256L	SETX_uc004cbj.2_Missense_Mutation_p.V1875L|SETX_uc010mzt.2_Missense_Mutation_p.V1875L	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2256					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CTGTACTGAACAGTGAGCTGT	0.428													58	254					0	0	0	0	G	135153533	G	G	135153533	3	3	43	1	0	0	0	0	1	0	0	0	14206	478	17	4	1291	4	SETX	9	135153533	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	4678051	135153533	6059898	67	9103											
C9orf37	85026	broad.mit.edu	37	chr9	140510521	140510521	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtttgtcagttaccttatctAtaaaatgcacaggaccaggc	12	12	8	9	0	2	0	1	0	1	0	2	1	2	1	2	2	2	3	2	2	5	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr9:140510521A>G	uc004cnz.2	-	3	715	c.131T>C	c.(130-132)ATA>ACA	p.I44T	EHMT1_uc004coa.2_5'Flank|EHMT1_uc004cob.1_5'Flank|EHMT1_uc011mfc.1_5'Flank	NM_032937	NP_116326	Q9H2J1	CI037_HUMAN	chromosome 9 open reading frame 37	44										breast(1)	1	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)		TACCTTATCTATAAAATGCAC	0.274													11	29					0	0	0	0	G	140510521	G	G	140510521	3	3	43	1	0	0	0	0	1	0	0	0	2491	449	16	5	403	5	C9orf37	9	140510521	Missense_Mutation	SNP	A	TCGA-CN-4731-01A-01D-1434-08	5356988	140510521	702910	68	9104											
CSTF2T	23283	broad.mit.edu	37	chr10	53459124	53459124	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtctcctggtcttggtattcGcagaagccatagcccttggg	6	12	12	11	1	2	1	0	0	2	1	4	1	2	1	3	3	2	2	3	3	3	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr10:53459124G>A	uc001jjp.2	-	1	232	c.186C>T	c.(184-186)TGC>TGT	p.C62C	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	62	RRM.				mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		CTTGGTATTCGCAGAAGCCAT	0.537													75	149					0	0	0	0	A	53459124	A	A	53459124	2	1	43	1	0	0	0	0	0	0	0	1	4002	1079	38	1		1	CSTF2T	10	53459124	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08		53459124	82075623	69	9105											
CCAR1	55749	broad.mit.edu	37	chr10	70531028	70531028	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttggtgtccgtatatacaaAtcattactgtctcttcctga	9	17	6	9	1	2	1	1	1	1	0	5	1	4	1	2	1	2	1	2	1	5	6			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr10:70531028A>G	uc001joo.2	+	18	2483	c.2364A>G	c.(2362-2364)AAA>AAG	p.K788K	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Silent_p.K593K|CCAR1_uc009xpx.1_Silent_p.K762K|CCAR1_uc001jon.1_Silent_p.K734K|CCAR1_uc010qiz.1_Silent_p.K773K|CCAR1_uc010qja.1_Silent_p.K773K|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	788	Glu-rich.				apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						GTATATACAAATCATTACTGT	0.199													54	118					0	0	0	0	G	70531028	G	G	70531028	2	3	43	1	0	0	0	0	0	0	0	1	2742	98	4	5		5	CCAR1	10	70531028	Silent	SNP	A	TCGA-CN-4731-01A-01D-1434-08	17071904	70531028	65003719	70	9106											
PLCE1	51196	broad.mit.edu	37	chr10	95995857	95995857	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctccaggaaaagctccttGaaggataaaagccgatggca	15	6	11	9	1	0	1	0	1	0	0	2	4	2	3	3	3	3	3	3	3	5	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr10:95995857G>A	uc001kjk.2	+	7	3034	c.2400G>A	c.(2398-2400)TTG>TTA	p.L800L	PLCE1_uc010qnx.1_Silent_p.L800L|PLCE1_uc001kjm.2_Silent_p.L492L	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	800					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				AAAGCTCCTTGAAGGATAAAA	0.458													12	86					0	0	0	0	A	95995857	A	A	95995857	2	1	43	1	0	0	0	0	0	0	0	1	12089	1281	45	2		2	PLCE1	10	95995857	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	25464829	95995857	39538890	71	9107											
HPS1	3257	broad.mit.edu	37	chr10	100182223	100182223	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaccatctgcccagtggtgCggtccacatagatgaagtgc	9	8	11	13	1	1	2	0	1	1	1	2	2	2	2	4	2	3	0	4	2	2	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr10:100182223C>T	uc010qpf.1	-	17	1892	c.1646G>A	c.(1645-1647)CGC>CAC	p.R549H	HPS1_uc001kpi.1_Missense_Mutation_p.R550H|HPS1_uc001kpj.1_Missense_Mutation_p.R457H|HPS1_uc001kpk.1_Missense_Mutation_p.R374H	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	549					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		CCCAGTGGTGCGGTCCACATA	0.562									Hermansky-Pudlak_syndrome				66	181					0	0	0	0	T	100182223	T	T	100182223	3	4	43	1	0	0	0	0	1	0	0	0	7378	768	27	1	472	1	HPS1	10	100182223	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	4186366	100182223	35352524	72	9108											
ABCC8	6833	broad.mit.edu	37	chr11	17427072	17427072	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttacagtcagatgaaaatCtgttcaggatgctcccaagg	12	11	10	8	0	3	2	2	1	1	1	4	3	4	3	1	2	2	3	1	2	4	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr11:17427072C>A	uc001mnc.2	-	27	3494	c.3368G>T	c.(3367-3369)AGA>ATA	p.R1123I		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1123	Cytoplasmic (By similarity).|ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGATGAAAATCTGTTCAGGAT	0.512													64	146					2.69673e-31	3.07073e-31	1	0	A	17427072	A	A	17427072	3	1	43	1	0	0	0	0	1	0	0	0	58	913	32	2	1429	2	ABCC8	11	17427072	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08		17427072	117579444	73	9109											
API5	8539	broad.mit.edu	37	chr11	43345053	43345053	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggttaaaaagcttacagaCagtgagtggaagacagcaac	16	7	12	6	0	0	3	0	1	0	2	0	4	0	4	0	2	4	3	0	2	6	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr11:43345053C>A	uc010rfh.1	+	6	790	c.617C>A	c.(616-618)ACA>AAA	p.T206K	API5_uc010rfg.1_Missense_Mutation_p.T195K|API5_uc001mxf.2_Missense_Mutation_p.T206K|API5_uc010rfi.1_Missense_Mutation_p.T152K|API5_uc001mxg.2_Missense_Mutation_p.T80K	NM_001142930	NP_001136402	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5 isoform a	206					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						AGCTTACAGACAGTGAGTGGA	0.438													50	94					6.18754e-15	6.56637e-15	1	0	A	43345053	A	A	43345053	3	1	43	1	0	0	0	0	1	0	0	0	773	478	17	4	639	4	API5	11	43345053	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	25917981	43345053	91661463	74	9110											
OR5T1	390155	broad.mit.edu	37	chr11	56043909	56043909	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggagtgacaatttatcatggGacaatcctcttcatgtatgt	11	14	9	7	0	3	1	2	1	1	0	4	3	4	3	1	2	0	1	1	2	4	4			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr11:56043909G>C	uc001nio.1	+	1	795	c.795G>C	c.(793-795)GGG>GGC	p.G265G		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	265	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TTTATCATGGGACAATCCTCT	0.418													219	247					0	0	0	0	C	56043909	C	C	56043909	2	2	43	1	0	0	0	0	0	0	0	1	11235	1161	41	2		2	OR5T1	11	56043909	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	12698856	56043909	78962607	75	9111											
VWCE	220001	broad.mit.edu	37	chr11	61042028	61042028	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgaacacagccccgtctgcGtaccaccggccgtggaaata	10	6	10	15	4	1	1	0	1	1	0	1	2	1	2	5	2	4	1	5	2	4	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr11:61042028G>C	uc001nra.2	-	12	1803	c.1524C>G	c.(1522-1524)TAC>TAG	p.Y508*	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	508	VWFC 3.					extracellular region	calcium ion binding			ovary(1)	1						CCCCGTCTGCGTACCACCGGC	0.552													30	147					0	0	0	0	C	61042028	C	C	61042028	4	2	43	1	0	0	0	0	0	1	0	0	17313	1140	40	3	1379	3	VWCE	11	61042028	Nonsense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	4998119	61042028	73964488	76	9112											
NDUFV1	4723	broad.mit.edu	37	chr11	67377002	67377002	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatcttacgccatgatcctCacaagctgctggaaggctgc	10	9	10	12	1	2	2	1	1	1	1	3	3	3	3	2	2	4	3	2	2	3	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr11:67377002C>T	uc001omj.2	+	4	559	c.406C>T	c.(406-408)CAC>TAC	p.H136Y	NDUFV1_uc010rpv.1_Missense_Mutation_p.H35Y|NDUFV1_uc001oml.2_Missense_Mutation_p.H129Y|NDUFV1_uc001omk.3_Missense_Mutation_p.H127Y|NDUFV1_uc009yrz.1_Missense_Mutation_p.H35Y|NDUFV1_uc010rpw.1_5'Flank	NM_007103	NP_009034	P49821	NDUV1_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 1	136					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)	CCATGATCCTCACAAGCTGCT	0.632													111	311					0	0	0	0	T	67377002	T	T	67377002	3	4	43	1	0	0	0	0	1	0	0	0	10353	826	29	2	420	2	NDUFV1	11	67377002	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	6334974	67377002	67629514	77	9113											
MYEOV	26579	broad.mit.edu	37	chr11	69062839	69062839	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcatggccctcagaatctgCgtcacatacaccccagctct	9	9	6	17	1	5	1	3	0	2	1	5	1	5	1	3	1	3	1	3	1	2	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr11:69062839C>A	uc001oov.2	+	2	468	c.18C>A	c.(16-18)TGC>TGA	p.C6*	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Nonsense_Mutation_p.C6*|MYEOV_uc001oow.2_Intron	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	6											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		tcagaatctgcgtcacataca	0.055													16	35					6.31663e-08	6.52579e-08	1	0	A	69062839	A	A	69062839	4	1	43	1	0	0	0	0	0	1	0	0	10078	776	27	3	20	3	MYEOV	11	69062839	Nonsense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	1685837	69062839	65943677	78	9114											
NCAPD2	9918	broad.mit.edu	37	chr12	6632162	6632162	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcaaccccaaaggggactCtgccaggtatatggggtgct	9	8	12	12	0	2	0	1	0	1	0	2	1	2	1	4	5	3	2	4	5	4	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr12:6632162C>G	uc001qoo.2	+	16	2169	c.2123C>G	c.(2122-2124)TCT>TGT	p.S708C	NCAPD2_uc009zen.1_Missense_Mutation_p.S580C|NCAPD2_uc010sfd.1_Missense_Mutation_p.S663C	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	708					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						AAAGGGGACTCTGCCAGGTAT	0.542													34	86					0	0	0	0	G	6632162	G	G	6632162	3	3	43	1	0	0	0	0	1	0	0	0	10259	913	32	2	2181	2	NCAPD2	12	6632162	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08		6632162	127219733	79	9115											
GYS2	2998	broad.mit.edu	37	chr12	21693415	21693415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctctggataatcctttggcGgcgtgactgtttgcaaaatc	8	13	10	10	2	1	1	0	1	1	0	3	2	2	2	2	3	1	2	2	3	3	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr12:21693415G>A	uc001rfb.2	-	14	1993	c.1738C>T	c.(1738-1740)CGC>TGC	p.R580C		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	580					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						ATCCTTTGGCGGCGTGACTGT	0.438													117	267					0	0	0	0	A	21693415	A	A	21693415	3	1	43	1	0	0	0	0	1	0	0	0	6952	1116	39	1	385	1	GYS2	12	21693415	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	15061253	21693415	112158480	80	9116											
MLL2	8085	broad.mit.edu	37	chr12	49435775	49435775	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaacggcttgaccagtcTggagggcagagagagtgagt	10	8	16	7	1	1	4	0	2	1	2	1	6	1	5	1	3	2	3	1	3	1	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr12:49435775T>C	uc001rta.3	-	29	6110	c.6110_splice	c.e29-1	p.D2037_splice		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2						chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTGACCAGTCTGGAGGGCAGA	0.557			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			14	2					0	0	0	0	C	49435775	C	C	49435775	5	2	43	1	0	0	0	0	0	0	1	0	9674	1594	55	5	10609	5	MLL2	12	49435775	Splice_Site	SNP	T	TCGA-CN-4731-01A-01D-1434-08	27742360	49435775	84416120	81	9117											
SCN8A	6334	broad.mit.edu	37	chr12	52201177	52201177	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggaagaagggaaagagcCaaaagacaaaaagaggtcag	22	1	14	4	0	1	4	1	0	0	4	1	7	1	6	1	3	1	0	1	3	8	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr12:52201177C>T	uc001ryw.2	+	27	6085	c.5907C>T	c.(5905-5907)GCC>GCT	p.A1969A	uc001rzb.1_5'Flank	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1969					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GGGAAAGAGCCAAAAGACAAA	0.428													16	23					0	0	0	0	T	52201177	T	T	52201177	2	4	43	1	0	0	0	0	0	0	0	1	13989	581	21	4		4	SCN8A	12	52201177	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	2765402	52201177	81650718	82	9118											
ACVR1B	91	broad.mit.edu	37	chr12	52378996	52378996	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaagcctggaattgctcatCgagacttaaagtcaaagaac	15	8	10	8	1	2	2	2	0	0	2	3	5	2	4	1	2	3	1	1	2	6	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr12:52378996C>T	uc001rzn.2	+	6	1042	c.1000C>T	c.(1000-1002)CGA>TGA	p.R334*	ACVR1B_uc001rzl.2_Nonsense_Mutation_p.R334*|ACVR1B_uc001rzm.2_Nonsense_Mutation_p.R334*|ACVR1B_uc010snn.1_Nonsense_Mutation_p.R375*	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	334	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	AATTGCTCATCGAGACTTAAA	0.363													44	32					0	0	0	0	T	52378996	T	T	52378996	4	4	43	1	0	0	0	0	0	1	0	0	221	876	31	1	1149	1	ACVR1B	12	52378996	Nonsense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	177819	52378996	81472899	83	9119											
KRT5	3852	broad.mit.edu	37	chr12	52910945	52910945	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctggatcatccggttcatCtcagagatctcatgcttggt	7	14	9	11	1	5	1	4	0	3	1	8	3	6	2	1	3	1	2	1	3	0	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr12:52910945C>G	uc001san.2	-	6	1327	c.1164G>C	c.(1162-1164)GAG>GAC	p.E388D	KRT5_uc009zmh.2_Missense_Mutation_p.E388D	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	388	Rod.|Coil 2.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCCGGTTCATCTCAGAGATCT	0.522													180	100					0	0	0	0	G	52910945	G	G	52910945	3	3	43	1	0	0	0	0	1	0	0	0	8518	912	32	2	624	2	KRT5	12	52910945	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	531949	52910945	80940950	84	9120											
LRP1	4035	broad.mit.edu	37	chr12	57571369	57571369	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcgcatcctttggattgaCgccaggtcagcaccctctgt	8	10	10	13	2	2	1	1	1	1	0	3	2	3	2	3	2	2	2	3	2	1	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr12:57571369C>T	uc001snd.2	+	26	4822	c.4356C>T	c.(4354-4356)GAC>GAT	p.D1452D		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1452	Extracellular (Potential).|LDL-receptor class B 11.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity	p.D1452D(1)		ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TTTGGATTGACGCCAGGTCAG	0.657													11	53					0	0	0	0	T	57571369	T	T	57571369	2	4	43	1	0	0	0	0	0	0	0	1	9001	535	19	1		1	LRP1	12	57571369	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	4660424	57571369	76280526	85	9121											
KCNMB4	27345	broad.mit.edu	37	chr12	70824419	70824419	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcggaagccatgaagaagCgcaagttctcttaaagggga	14	6	14	7	2	1	2	0	1	1	1	2	4	1	4	1	4	2	2	1	4	6	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr12:70824419C>T	uc001svx.2	+	3	1072	c.619C>T	c.(619-621)CGC>TGC	p.R207C	uc001svy.1_5'Flank	NM_014505	NP_055320	Q86W47	KCMB4_HUMAN	calcium-activated potassium channel beta 4	207	Cytoplasmic (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding				0	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			CATGAAGAAGCGCAAGTTCTC	0.552													54	15					0	0	0	0	T	70824419	T	T	70824419	3	4	43	1	0	0	0	0	1	0	0	0	8116	768	27	1	629	1	KCNMB4	12	70824419	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	13253050	70824419	63027476	86	9122											
CAMKK2	10645	broad.mit.edu	37	chr12	121701709	121701709	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggctggatgcagcctccaGgagctggccgggtgcctcgg	4	7	18	12	2	0	0	0	0	0	0	2	2	1	2	4	6	4	3	4	6	0	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr12:121701709G>A	uc001tzu.2	-	6	783	c.659C>T	c.(658-660)CCT>CTT	p.P220L	CAMKK2_uc001tzt.2_Missense_Mutation_p.P220L|CAMKK2_uc001tzv.2_Missense_Mutation_p.P220L|CAMKK2_uc001tzw.2_Missense_Mutation_p.P220L|CAMKK2_uc001tzx.2_Missense_Mutation_p.P220L|CAMKK2_uc001tzy.2_Missense_Mutation_p.P220L|CAMKK2_uc001uaa.1_Missense_Mutation_p.P220L|CAMKK2_uc001uab.2_Missense_Mutation_p.P220L|CAMKK2_uc001uac.2_Missense_Mutation_p.P220L	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase	220	RP domain.|Protein kinase.				calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GCAGCCTCCAGGAGCTGGCCG	0.612													41	26					0	0	0	0	A	121701709	A	A	121701709	3	1	43	1	0	0	0	0	1	0	0	0	2619	1000	35	4	1165	4	CAMKK2	12	121701709	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	50877290	121701709	12150186	87	9123											
RNF17	56163	broad.mit.edu	37	chr13	25374506	25374506	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacttgaatttctcctagagTtgttgatacccatgtgagac	10	15	8	8	0	1	4	0	3	1	2	2	5	1	4	2	0	2	2	2	0	4	7			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr13:25374506T>C	uc001upr.2	+	13	1633	c.1592T>C	c.(1591-1593)GTT>GCT	p.V531A	RNF17_uc010tdd.1_Missense_Mutation_p.V390A|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.V531A|RNF17_uc001ups.2_Missense_Mutation_p.V470A	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	531					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TCTCCTAGAGTTGTTGATACC	0.328													53	159					0	0	0	0	C	25374506	C	C	25374506	3	2	43	1	0	0	0	0	1	0	0	0	13526	1725	60	5	1642	5	RNF17	13	25374506	Missense_Mutation	SNP	T	TCGA-CN-4731-01A-01D-1434-08		25374506	89795372	88	9124											
FREM2	341640	broad.mit.edu	37	chr13	39264672	39264672	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccatcctgcctgttgataGccaggccccagaaatctttg	9	10	9	13	0	1	2	0	1	1	1	2	3	2	2	6	1	2	1	6	1	2	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr13:39264672G>T	uc001uwv.2	+	1	3500	c.3191G>T	c.(3190-3192)AGC>ATC	p.S1064I		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1064	Extracellular (Potential).|CSPG 7.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCTGTTGATAGCCAGGCCCCA	0.413													92	168					4.08182e-41	4.68209e-41	1	0	T	39264672	T	T	39264672	3	4	43	1	0	0	0	0	1	0	0	0	6079	971	34	4	3193	4	FREM2	13	39264672	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	13890166	39264672	75905206	89	9125											
L2HGDH	79944	broad.mit.edu	37	chr14	50736050	50736050	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacatcgaatttcctctcccTagtgcaaaataaaagaacag	16	9	6	10	1	1	1	0	0	1	1	4	3	2	1	2	0	2	1	2	0	7	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr14:50736050T>G	uc001wxu.2	-	7	818	c.739_splice	c.e7-1	p.G247_splice	L2HGDH_uc010tqn.1_Splice_Site_p.G247_splice|L2HGDH_uc010tqo.1_Splice_Site_p.G247_splice	NM_024884	NP_079160	Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase precursor						2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)					TTCCTCTCCCTAGTGCAAAAT	0.383													154	70					0	0	0	0	G	50736050	G	G	50736050	5	3	43	1	0	0	0	0	0	0	1	0	8630	1536	53	5	670	5	L2HGDH	14	50736050	Splice_Site	SNP	T	TCGA-CN-4731-01A-01D-1434-08		50736050	56613490	90	9126											
HIF1A	3091	broad.mit.edu	37	chr14	62207599	62207599	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccctgaaagcgcaagtcctCaaagcacagttacagtattc	13	8	8	12	1	1	1	1	1	0	0	3	1	2	1	2	0	3	4	2	0	5	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr14:62207599C>G	uc001xfq.2	+	12	2190	c.1786C>G	c.(1786-1788)CAA>GAA	p.Q596E	HIF1A_uc001xfr.2_Missense_Mutation_p.Q596E|HIF1A_uc001xfs.2_Missense_Mutation_p.Q597E	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	596	ID.|ODD.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		CGCAAGTCCTCAAAGCACAGT	0.448													55	106					0	0	0	0	G	62207599	G	G	62207599	3	3	43	1	0	0	0	0	1	0	0	0	7142	827	29	2	1832	2	HIF1A	14	62207599	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	11471549	62207599	45141941	91	9127											
SLC8A3	6547	broad.mit.edu	37	chr14	70515625	70515625	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gatggagacggcgaagcaggCccagccgtggcagtactctg	9	5	16	11	3	1	1	0	0	1	1	1	4	1	1	2	4	3	3	2	4	2	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr14:70515625C>G	uc001xly.2	-	7	3020	c.2266G>C	c.(2266-2268)GCC>CCC	p.A756P	SLC8A3_uc001xlu.2_Missense_Mutation_p.A113P|SLC8A3_uc001xlv.2_Missense_Mutation_p.A127P|SLC8A3_uc001xlw.2_Missense_Mutation_p.A753P|SLC8A3_uc001xlx.2_Missense_Mutation_p.A754P|SLC8A3_uc001xlz.2_Missense_Mutation_p.A750P|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_Missense_Mutation_p.A113P	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	756	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GCGAAGCAGGCCCAGCCGTGG	0.582													8	27					0	0	0	0	G	70515625	G	G	70515625	3	3	43	1	0	0	0	0	1	0	0	0	14772	739	26	4	525	4	SLC8A3	14	70515625	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	8308026	70515625	36833915	92	9128											
SERPINA4	5267	broad.mit.edu	37	chr14	95033334	95033334	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagaaaccattcatttcctCaaggaccactcccaaagact	14	8	6	13	0	2	2	2	0	0	2	4	4	4	3	4	2	1	0	4	2	3	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr14:95033334C>G	uc001ydk.2	+	3	743	c.677C>G	c.(676-678)TCA>TGA	p.S226*	SERPINA4_uc010avd.2_Nonsense_Mutation_p.S263*|SERPINA4_uc001ydl.2_Nonsense_Mutation_p.S226*	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	226					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		TTCATTTCCTCAAGGACCACT	0.512													39	100					0	0	0	0	G	95033334	G	G	95033334	4	3	43	1	0	0	0	0	0	1	0	0	14156	838	29	2	683	2	SERPINA4	14	95033334	Nonsense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	24517709	95033334	12316206	93	9129											
FMN1	342184	broad.mit.edu	37	chr15	33260945	33260945	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttatttgtatcctagtccaaTataaaggcttcatgggacaa	13	14	7	7	0	1	0	1	0	0	0	3	1	3	1	2	2	0	2	2	2	8	7			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr15:33260945T>C	uc001zhf.3	-	4	2288	c.2288A>G	c.(2287-2289)TAT>TGT	p.Y763C		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	986	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CCTAGTCCAATATAAAGGCTT	0.463													86	169					0	0	0	0	C	33260945	C	C	33260945	3	2	43	1	0	0	0	0	1	0	0	0	5981	1406	49	5	1358	5	FMN1	15	33260945	Missense_Mutation	SNP	T	TCGA-CN-4731-01A-01D-1434-08		33260945	69270447	94	9130											
PKD1	5310	broad.mit.edu	37	chr16	2168022	2168022	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgcccaggcagcacatagCgatgcgaggcagccggccca	10	2	14	15	4	0	0	0	0	0	0	0	2	0	0	3	3	5	3	3	3	1	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:2168022C>T	uc002cos.1	-	5	1180	c.971G>A	c.(970-972)CGC>CAC	p.R324H	PKD1_uc002cot.1_Missense_Mutation_p.R324H	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	324	Extracellular (Potential).|PKD 1.		R -> L (in ADPKD1).		calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CAGCACATAGCGATGCGAGGC	0.711													10	12					0	0	0	0	T	2168022	T	T	2168022	3	4	43	1	0	0	0	0	1	0	0	0	12018	768	27	1	12108	1	PKD1	16	2168022	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08		2168022	88186731	95	9131											
PGP	283871	broad.mit.edu	37	chr16	2264251	2264251	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtgagcttcatgtagctGaagtgcgggtcaaagcccac	9	10	13	9	1	2	2	2	2	0	0	2	2	2	2	1	2	4	3	1	2	3	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:2264251G>C	uc002cpk.1	-	1	572	c.528C>G	c.(526-528)TTC>TTG	p.F176L	PGP_uc010uvz.1_RNA	NM_001042371	NP_001035830	A6NDG6	PGP_HUMAN	phosphoglycolate phosphatase	176					carbohydrate metabolic process		phosphoglycolate phosphatase activity			skin(1)	1						TCATGTAGCTGAAGTGCGGGT	0.697													6	25					0	0	0	0	C	2264251	C	C	2264251	3	2	43	1	0	0	0	0	1	0	0	0	11857	1281	45	2	445	2	PGP	16	2264251	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	96229	2264251	88090502	96	9132											
ZG16B	124220	broad.mit.edu	37	chr16	2881955	2881955	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgtacaccagcaaggaccGctatttctattttgggaagc	11	11	9	10	1	1	0	0	0	1	0	1	2	1	2	2	2	3	3	2	2	5	6			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:2881955G>A	uc002cru.2	+	4	498	c.422G>A	c.(421-423)CGC>CAC	p.R141H		NM_145252	NP_660295	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16 homolog B precursor	141						extracellular region	sugar binding			ovary(1)	1						AGCAAGGACCGCTATTTCTAT	0.537													49	103					0	0	0	0	A	2881955	A	A	2881955	3	1	43	1	0	0	0	0	1	0	0	0	17739	1087	38	1	436	1	ZG16B	16	2881955	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	617704	2881955	87472798	97	9133											
NLRC3	197358	broad.mit.edu	37	chr16	3613683	3613683	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacaccaaacgccttcatgtCttgctcgtaaaacacgtatt	12	12	5	12	3	2	0	1	0	1	0	3	0	2	0	2	0	4	3	2	0	5	6			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:3613683C>G	uc010btn.2	-	5	1666	c.1255G>C	c.(1255-1257)GAC>CAC	p.D419H		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	419	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GCCTTCATGTCTTGCTCGTAA	0.592													16	31					0	0	0	0	G	3613683	G	G	3613683	3	3	43	1	0	0	0	0	1	0	0	0	10522	913	32	2	2007	2	NLRC3	16	3613683	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	731728	3613683	86741070	98	9134											
ACSM2B	348158	broad.mit.edu	37	chr16	20565181	20565181	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accactggtcccactagtgaAgtagatggcagatgcttcct	10	10	10	11	0	0	3	0	1	0	2	2	3	2	3	3	2	1	3	3	2	3	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:20565181A>G	uc002dhj.3	-	6	868	c.658T>C	c.(658-660)TTC>CTC	p.F220L	ACSM2B_uc002dhk.3_Missense_Mutation_p.F220L|ACSM2B_uc010bwf.1_Missense_Mutation_p.F220L	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	220					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CCACTAGTGAAGTAGATGGCA	0.512													61	119					0	0	0	0	G	20565181	G	G	20565181	3	3	43	1	0	0	0	0	1	0	0	0	184	72	3	5	1115	5	ACSM2B	16	20565181	Missense_Mutation	SNP	A	TCGA-CN-4731-01A-01D-1434-08	16951498	20565181	69789572	99	9135											
KCTD13	253980	broad.mit.edu	37	chr16	29923281	29923281	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagggcttgggggcctcacCttggaggtgctggccaggag	5	7	19	10	0	1	0	1	0	0	0	1	2	1	2	3	7	1	3	3	7	0	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:29923281C>T	uc002duv.2	-	3	695	c.504G>A	c.(502-504)AAG>AAA	p.K168K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ASPHD1_uc002duu.3_Intron|ASPHD1_uc010bzi.2_Intron|KCTD13_uc010vee.1_RNA	NM_178863	NP_849194	Q8WZ19	BACD1_HUMAN	potassium channel tetramerisation domain	168					cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0						GGGGCCTCACCTTGGAGGTGC	0.672													14	24					0	0	0	0	T	29923281	T	T	29923281	2	4	43	1	0	0	0	0	0	0	0	1	8139	695	24	4		4	KCTD13	16	29923281	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	9358100	29923281	60431472	100	9136											
ITGAM	3684	broad.mit.edu	37	chr16	31332573	31332573	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccctcagcggatagcaggCtccaagctctctcccaggct	8	8	9	16	1	2	0	1	0	1	0	5	1	4	1	3	3	4	4	3	3	3	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:31332573C>A	uc002ebq.2	+	15	1817	c.1719C>A	c.(1717-1719)GGC>GGA	p.G573G	ITGAM_uc002ebr.2_Silent_p.G574G|ITGAM_uc010cam.1_Intron|ITGAM_uc010can.2_5'UTR|ITGAM_uc002ebs.1_5'UTR	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	573	Extracellular (Potential).|FG-GAP 7.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GGATAGCAGGCTCCAAGCTCT	0.542													108	260					2.13259e-42	2.46432e-42	1	0	A	31332573	A	A	31332573	2	1	43	1	0	0	0	0	0	0	0	1	7926	784	28	4		4	ITGAM	16	31332573	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	1409292	31332573	59022180	101	9137											
ARMC5	79798	broad.mit.edu	37	chr16	31477249	31477249	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgacgcacctgctgctctCtgggagccctgaggaccgag	6	7	13	15	2	1	2	0	2	1	0	2	5	1	4	4	2	3	3	4	2	0	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:31477249C>T	uc002ecc.2	+	5	2472	c.1943C>T	c.(1942-1944)TCT>TTT	p.S648F	ARMC5_uc010vfn.1_Missense_Mutation_p.S743F|ARMC5_uc010vfo.1_Missense_Mutation_p.S680F|ARMC5_uc002eca.3_3'UTR|ARMC5_uc010vfp.1_Missense_Mutation_p.S456F|ARMC5_uc002ecb.2_Missense_Mutation_p.S648F	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	648							binding			pancreas(1)	1						CTGCTGCTCTCTGGGAGCCCT	0.647													4	110					0	0	0	0	T	31477249	T	T	31477249	3	4	43	1	0	0	0	0	1	0	0	0	956	913	32	2	2275	2	ARMC5	16	31477249	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	144676	31477249	58877504	102	9138											
RPGRIP1L	23322	broad.mit.edu	37	chr16	53639439	53639439	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcccttcctgaaacatgtcGgcaaggtcgacgtgagccac	9	8	10	14	3	0	2	0	2	0	0	4	3	2	2	3	2	2	1	3	2	2	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:53639439G>A	uc002ehp.2	-	26	3853	c.3789C>T	c.(3787-3789)GCC>GCT	p.A1263A	RPGRIP1L_uc002eho.3_Silent_p.A1183A|RPGRIP1L_uc010vgy.1_Silent_p.A1217A|RPGRIP1L_uc010cbx.2_Silent_p.A1229A|RPGRIP1L_uc010vgz.1_Silent_p.A1217A	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	1263					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				GAAACATGTCGGCAAGGTCGA	0.527													36	98					0	0	0	0	A	53639439	A	A	53639439	2	1	43	1	0	0	0	0	0	0	0	1	13615	1103	39	1		1	RPGRIP1L	16	53639439	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	22162190	53639439	36715314	103	9139											
WWOX	51741	broad.mit.edu	37	chr16	78133748	78133748	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctccgggctgggaggagAgaaccaccaaggacggctgg	9	4	17	11	2	0	1	0	0	0	1	1	5	1	4	4	6	2	2	4	6	2	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:78133748A>T	uc002ffk.2	+	1	198	c.73A>T	c.(73-75)AGA>TGA	p.R25*	WWOX_uc010vnk.1_5'UTR|WWOX_uc002ffl.2_Nonsense_Mutation_p.R25*|WWOX_uc010che.2_Nonsense_Mutation_p.R25*|WWOX_uc002ffj.1_Nonsense_Mutation_p.R25*|WWOX_uc002ffi.1_Nonsense_Mutation_p.R25*	NM_016373	NP_057457	Q9NZC7	WWOX_HUMAN	WW domain-containing oxidoreductase isoform 1	25	WW 1.				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity				0		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		CTGGGAGGAGAGAACCACCAA	0.701											OREG0023952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	9					0	0	0	0	T	78133748	T	T	78133748	4	4	43	1	0	0	0	0	0	1	0	0	17482	296	11	5	75	5	WWOX	16	78133748	Nonsense_Mutation	SNP	A	TCGA-CN-4731-01A-01D-1434-08	24494309	78133748	12221005	104	9140											
ATMIN	23300	broad.mit.edu	37	chr16	81077308	81077308	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttacaagaactagggaacaCgtgtcaaaagaatagcattt	17	10	8	6	1	1	2	1	0	0	2	1	3	1	3	0	1	4	1	0	1	9	5	rs139034682		TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:81077308C>T	uc002ffz.1	+	4	1223	c.1205C>T	c.(1204-1206)ACG>ATG	p.T402M	ATMIN_uc002fga.2_Missense_Mutation_p.T244M|ATMIN_uc010vnn.1_Missense_Mutation_p.T173M|ATMIN_uc002fgb.1_Missense_Mutation_p.T244M	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	402	Required for formation of RAD51 foci.				response to DNA damage stimulus	nucleus	zinc ion binding				0						CTAGGGAACACGTGTCAAAAG	0.403													76	140					0	0	0	0	T	81077308	T	T	81077308	3	4	43	1	0	0	0	0	1	0	0	0	1112	536	19	1	1219	1	ATMIN	16	81077308	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	2943560	81077308	9277445	105	9141											
CDH15	1013	broad.mit.edu	37	chr16	89257810	89257810	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccggatccagacccagcaCgtgctcagcccggcgtcccc	6	4	12	19	4	1	1	1	0	0	1	3	2	3	2	6	3	3	2	6	3	0	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr16:89257810C>T	uc002fmt.2	+	9	1382	c.1305C>T	c.(1303-1305)CAC>CAT	p.H435H		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	435	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		AGACCCAGCACGTGCTCAGCC	0.672													24	35					0	0	0	0	T	89257810	T	T	89257810	2	4	43	1	0	0	0	0	0	0	0	1	3115	535	19	1		1	CDH15	16	89257810	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	8180502	89257810	1096943	106	9142											
POLR2A	5430	broad.mit.edu	37	chr17	7415500	7415500	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgtgcttatggaagcagcCgcacacggtgagagtgaccc	10	6	14	11	3	0	2	0	2	0	1	0	5	0	3	2	2	3	3	2	2	2	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:7415500C>T	uc002ghf.3	+	26	4563	c.4329C>T	c.(4327-4329)GCC>GCT	p.A1443A		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1443					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				TGGAAGCAGCCGCACACGGTG	0.617													25	47					0	0	0	0	T	7415500	T	T	7415500	2	4	43	1	0	0	0	0	0	0	0	1	12269	639	23	1		1	POLR2A	17	7415500	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08		7415500	73779710	107	9143											
TP53	7157	broad.mit.edu	37	chr17	7578419	7578419	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggggcagcgcctcacaacctCcgtcatgtgctgtgactgct	6	9	12	14	2	2	1	2	1	0	0	3	1	3	1	3	2	4	3	3	2	1	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:7578419C>A	uc002gim.2	-	5	705	c.511G>T	c.(511-513)GAG>TAG	p.E171*	TP53_uc002gig.1_Nonsense_Mutation_p.E171*|TP53_uc002gih.2_Nonsense_Mutation_p.E171*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E39*|TP53_uc010cng.1_Nonsense_Mutation_p.E39*|TP53_uc002gii.1_Nonsense_Mutation_p.E39*|TP53_uc010cnh.1_Nonsense_Mutation_p.E171*|TP53_uc010cni.1_Nonsense_Mutation_p.E171*|TP53_uc002gij.2_Nonsense_Mutation_p.E171*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.E78*|TP53_uc002gio.2_Nonsense_Mutation_p.E39*|TP53_uc010vug.1_Nonsense_Mutation_p.E132*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	171	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E171*(10)|p.E171K(8)|p.0?(7)|p.E171G(3)|p.E171Q(3)|p.E171fs*10(3)|p.E171fs*3(2)|p.E171V(2)|p.E171D(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.E171fs*9(1)|p.T170fs*2(1)|p.E171fs*1(1)|p.T170fs*8(1)|p.E171_V172delEV(1)|p.H168fs*69(1)|p.T170_E171insXX(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.E171A(1)|p.H168fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCACAACCTCCGTCATGTGC	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			69	45					4.67498e-28	5.24674e-28	1	0	A	7578419	A	A	7578419	4	1	43	1	0	0	0	0	0	1	0	0	16448	864	30	2	787	2	TP53	17	7578419	Nonsense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	162919	7578419	73616791	108	9144											
DNAH2	146754	broad.mit.edu	37	chr17	7734485	7734485	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacatcagcttattgcctggCatggacccccctgaggcctt	7	11	9	14	0	1	1	1	1	0	0	1	2	1	2	5	3	3	2	5	3	2	4			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:7734485C>T	uc002giu.1	+	79	12326	c.12312C>T	c.(12310-12312)GGC>GGT	p.G4104G	DNAH2_uc010cnm.1_Silent_p.G1042G	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4104	TPR 4.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TATTGCCTGGCATGGACCCCC	0.507													170	429					0	0	0	0	T	7734485	T	T	7734485	2	4	43	1	0	0	0	0	0	0	0	1	4624	697	25	4		4	DNAH2	17	7734485	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	156066	7734485	73460725	109	9145											
MYH8	4626	broad.mit.edu	37	chr17	10295236	10295236	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgtatgatttcaccttcGcctgtaatttatctaccaag	9	17	5	10	1	3	1	1	1	2	0	4	1	3	1	3	0	1	2	3	0	5	8			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:10295236G>A	uc002gmm.2	-	39	5722	c.5627C>T	c.(5626-5628)GCG>GTG	p.A1876V	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1876	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTTCACCTTCGCCTGTAATTT	0.383									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				115	282					0	0	0	0	A	10295236	A	A	10295236	3	1	43	1	0	0	0	0	1	0	0	0	10094	1087	38	1	194	1	MYH8	17	10295236	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	2560751	10295236	70899974	110	9146											
MPRIP	23164	broad.mit.edu	37	chr17	17079760	17079760	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcttattgcgggtaaaggaAtcggaaatacagtacctgaa	14	10	11	6	2	1	1	0	1	1	0	2	3	1	3	1	3	3	2	1	3	8	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:17079760A>G	uc002gqu.1	+	20	2786	c.2730A>G	c.(2728-2730)GAA>GAG	p.E910E	MPRIP_uc002gqv.1_Silent_p.E910E|MPRIP_uc002gqw.1_Silent_p.E665E|MPRIP_uc002gqx.1_Silent_p.E1139E|MPRIP_uc002gqy.1_Silent_p.E1139E|MPRIP_uc010cpl.1_Silent_p.E96E|MPRIP_uc010cpm.1_Silent_p.E96E	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	910	Potential.					cytoplasm|cytoskeleton	actin binding				0						GGGTAAAGGAATCGGAAATAC	0.532													77	190					0	0	0	0	G	17079760	G	G	17079760	2	3	43	1	0	0	0	0	0	0	0	1	9796	98	4	5		5	MPRIP	17	17079760	Silent	SNP	A	TCGA-CN-4731-01A-01D-1434-08	6784524	17079760	64115450	111	9147											
CYTSB	92521	broad.mit.edu	37	chr17	20109083	20109083	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccagtgctgtggagcagaCggcagagagctgcgaagttc	9	6	17	9	2	0	2	0	0	0	2	1	5	0	3	1	3	4	5	1	3	1	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:20109083C>T	uc002gwq.2	+	4	1866	c.1721C>T	c.(1720-1722)ACG>ATG	p.T574M	CYTSB_uc010cqx.2_Missense_Mutation_p.T574M|CYTSB_uc002gwr.2_Missense_Mutation_p.T574M|CYTSB_uc002gws.2_Missense_Mutation_p.T574M|CYTSB_uc002gwv.2_Missense_Mutation_p.T493M|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Missense_Mutation_p.T350M|CYTSB_uc002gwt.2_Missense_Mutation_p.T493M|CYTSB_uc002gwu.2_Missense_Mutation_p.T493M	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	574						nucleus					0						GTGGAGCAGACGGCAGAGAGC	0.463													53	104					0	0	0	0	T	20109083	T	T	20109083	3	4	43	1	0	0	0	0	1	0	0	0	4227	536	19	1	1775	1	CYTSB	17	20109083	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	3029323	20109083	61086127	112	9148											
TRAF4	9618	broad.mit.edu	37	chr17	27075534	27075534	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttctgtggccccagagccaCcagtaccagtgcccaaggct	8	7	10	16	0	1	1	0	0	1	1	1	1	1	1	6	2	3	2	6	2	2	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:27075534C>T	uc002hcs.2	+	6	738	c.630C>T	c.(628-630)CAC>CAT	p.H210H	TRAF4_uc002hcq.1_Intron	NM_004295	NP_004286	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	210	TRAF-type 3.				apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			upper_aerodigestive_tract(1)|lung(1)	2	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			CCCAGAGCCACCAGTACCAGT	0.597													12	32					0	0	0	0	T	27075534	T	T	27075534	2	4	43	1	0	0	0	0	0	0	0	1	16510	506	18	4		4	TRAF4	17	27075534	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	6966451	27075534	54119676	113	9149											
COL1A1	1277	broad.mit.edu	37	chr17	48263803	48263803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacgcaggtctcaccagtctCcatgttgcagaagactttga	10	10	9	12	1	2	3	1	1	2	2	4	3	2	3	2	1	1	3	2	1	1	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:48263803C>T	uc002iqm.2	-	49	4006	c.3880G>A	c.(3880-3882)GAG>AAG	p.E1294K		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	1294	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	TCACCAGTCTCCATGTTGCAG	0.552			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						50	98					0	0	0	0	T	48263803	T	T	48263803	3	4	43	1	0	0	0	0	1	0	0	0	3692	864	30	2	526	2	COL1A1	17	48263803	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	21188269	48263803	32931407	114	9150											
LUC7L3	51747	broad.mit.edu	37	chr17	48823124	48823124	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacctgatcgtgatgagcGtctaaaaaaggagaagcaag	17	6	12	6	2	1	5	0	3	1	2	2	6	1	5	1	1	3	1	1	1	6	1	rs146274793	byFrequency	TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:48823124G>A	uc002isr.2	+	8	854	c.737G>A	c.(736-738)CGT>CAT	p.R246H	LUC7L3_uc010wmw.1_Missense_Mutation_p.R170H|LUC7L3_uc002isq.2_Missense_Mutation_p.R246H|LUC7L3_uc002iss.2_Missense_Mutation_p.R246H	NM_006107	NP_006098	O95232	LC7L3_HUMAN	LUC7-like 3	246	Arg/Ser-rich.|Glu-rich.				apoptosis|mRNA processing|response to stress|RNA splicing	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding				0						CGTGATGAGCGTCTAAAAAAG	0.189													14	26					0	0	0	0	A	48823124	A	A	48823124	3	1	43	1	0	0	0	0	1	0	0	0	9134	1145	40	1	767	1	LUC7L3	17	48823124	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	559321	48823124	32372086	115	9151											
BCAS3	54828	broad.mit.edu	37	chr17	59115302	59115302	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacattatcagttgctatggCaccttagtggaacacatgat	12	13	8	8	0	1	1	1	1	0	0	1	2	1	2	1	2	3	3	1	2	5	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:59115302C>A	uc002iyv.3	+	19	1969	c.1860C>A	c.(1858-1860)GGC>GGA	p.G620G	BCAS3_uc010wow.1_Silent_p.G392G|BCAS3_uc002iyu.3_Silent_p.G605G|BCAS3_uc002iyw.3_Silent_p.G601G|BCAS3_uc002iyy.3_Silent_p.G376G|BCAS3_uc002iyz.3_Silent_p.G174G|BCAS3_uc002iza.3_Silent_p.G159G	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	620						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			GTTGCTATGGCACCTTAGTGG	0.478													252	113					8.49039e-111	9.88433e-111	1	0	A	59115302	A	A	59115302	2	1	43	1	0	0	0	0	0	0	0	1	1354	697	25	4		4	BCAS3	17	59115302	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	10292178	59115302	22079908	116	9152											
FTSJ3	117246	broad.mit.edu	37	chr17	61897782	61897782	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccggaagctccccctcatCctcattaaatgtgtacctga	9	11	6	15	1	2	1	2	1	0	0	5	2	5	2	5	1	2	2	5	1	4	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr17:61897782C>T	uc002jbz.2	-	18	2167	c.2089G>A	c.(2089-2091)GAT>AAT	p.D697N	FTSJ3_uc002jca.2_Missense_Mutation_p.D697N	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	697					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						TCCCCCTCATCCTCATTAAAT	0.413													56	143					0	0	0	0	T	61897782	T	T	61897782	3	4	43	1	0	0	0	0	1	0	0	0	6123	855	30	2	466	2	FTSJ3	17	61897782	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	2782480	61897782	19297428	117	9153											
EPB41L3	23136	broad.mit.edu	37	chr18	5397351	5397351	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggtctcctgcaccaccttCtcagtgctaagcggcaggtg	7	9	11	14	2	2	0	1	0	2	0	4	0	2	0	3	3	3	3	3	3	1	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr18:5397351C>G	uc002kmt.1	-	18	2633	c.2547G>C	c.(2545-2547)GAG>GAC	p.E849D	EPB41L3_uc010wzh.1_Missense_Mutation_p.E680D|EPB41L3_uc002kmu.1_Missense_Mutation_p.E627D|EPB41L3_uc010dkq.1_Missense_Mutation_p.E518D|EPB41L3_uc002kms.1_Missense_Mutation_p.E84D|EPB41L3_uc010wze.1_Missense_Mutation_p.E154D|EPB41L3_uc010wzf.1_Missense_Mutation_p.E146D|EPB41L3_uc010wzg.1_Missense_Mutation_p.E121D|EPB41L3_uc010dkr.2_Missense_Mutation_p.E241D	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	849	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GCACCACCTTCTCAGTGCTAA	0.592													44	69					0	0	0	0	G	5397351	G	G	5397351	3	3	43	1	0	0	0	0	1	0	0	0	5178	912	32	2	736	2	EPB41L3	18	5397351	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08		5397351	72679897	118	9154											
RIOK3	8780	broad.mit.edu	37	chr18	21053506	21053506	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaatatattaaagatgattTcaggtttaaagatcgcttca	16	14	6	5	1	2	3	2	1	0	2	3	3	2	3	0	1	0	2	0	1	7	7			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr18:21053506T>A	uc002kui.3	+	8	1546	c.929T>A	c.(928-930)TTC>TAC	p.F310Y	RIOK3_uc010dls.2_Missense_Mutation_p.F310Y|RIOK3_uc010xas.1_Missense_Mutation_p.F294Y|RIOK3_uc010xat.1_Intron	NM_003831	NP_003822	O14730	RIOK3_HUMAN	sudD suppressor of bimD6 homolog	310	Protein kinase.				chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AAAGATGATTTCAGGTTTAAA	0.328													22	56					0	0	0	0	A	21053506	A	A	21053506	3	1	43	1	0	0	0	0	1	0	0	0	13444	1783	62	5	959	5	RIOK3	18	21053506	Missense_Mutation	SNP	T	TCGA-CN-4731-01A-01D-1434-08	15656155	21053506	57023742	119	9155											
ST8SIA3	51046	broad.mit.edu	37	chr18	55024676	55024676	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagtccaactggcttggccgGgaaatataatgcaacatgtc	13	9	10	9	1	0	0	0	0	0	0	2	1	1	1	2	3	3	2	2	3	6	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr18:55024676G>A	uc002lgn.2	+	3	1192	c.835G>A	c.(835-837)GGA>AGA	p.G279R		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	279	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	p.G279E(1)		breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		GGCTTGGCCGGGAAATATAAT	0.408													57	142					0	0	0	0	A	55024676	A	A	55024676	3	1	43	1	0	0	0	0	1	0	0	0	15299	1233	43	4	845	4	ST8SIA3	18	55024676	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	33971170	55024676	23052572	120	9156											
DOCK6	57572	broad.mit.edu	37	chr19	11363491	11363491	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atcccgggctccgtggtccgGcattcccggggctgcagcag	4	7	15	15	4	0	0	0	0	0	0	4	0	4	0	4	5	2	5	4	5	0	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr19:11363491G>A	uc002mqs.3	-	3	317	c.276C>T	c.(274-276)TGC>TGT	p.C92C		NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	92					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CCGTGGTCCGGCATTCCCGGG	0.622													3	44					0	0	0	0	A	11363491	A	A	11363491	2	1	43	1	0	0	0	0	0	0	0	1	4713	1195	42	4		4	DOCK6	19	11363491	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08		11363491	47765492	121	9157											
CACNA1A	773	broad.mit.edu	37	chr19	13323202	13323202	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggggacagaggcacctgaGagttaggctggctgttgggc	7	8	19	7	0	0	2	0	1	0	2	0	4	0	3	1	6	0	5	1	6	1	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr19:13323202G>C	uc010dze.2	-	42	6424	c.6188C>G	c.(6187-6189)TCT>TGT	p.S2063C	CACNA1A_uc010xnd.1_Missense_Mutation_p.S768C|CACNA1A_uc002mwx.3_Missense_Mutation_p.S768C|CACNA1A_uc010dzc.2_Missense_Mutation_p.S1588C|CACNA1A_uc002mwy.3_Missense_Mutation_p.S2062C|CACNA1A_uc002mwv.3_Missense_Mutation_p.S579C	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	2063	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AGGCACCTGAGAGTTAGGCTG	0.647													5	36					0	0	0	0	C	13323202	C	C	13323202	3	2	43	1	0	0	0	0	1	0	0	0	2550	942	33	2	1359	2	CACNA1A	19	13323202	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	1959711	13323202	45805781	122	9158											
ABHD8	79575	broad.mit.edu	37	chr19	17412027	17412027	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgccgctgcctgcgctgccGggggccaagcggccatcgct	3	6	15	17	5	0	0	0	0	0	0	1	0	0	0	5	3	5	3	5	3	1	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr19:17412027G>A	uc002ngb.3	-	2	639	c.399C>T	c.(397-399)CCC>CCT	p.P133P		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	133							hydrolase activity				0						ctgcgctgccgGGGGCCAAGC	0.507													9	14					0	0	0	0	A	17412027	A	A	17412027	2	1	43	1	0	0	0	0	0	0	0	1	87	1103	39	1		1	ABHD8	19	17412027	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	4088825	17412027	41716956	123	9159											
ZNF529	57711	broad.mit.edu	37	chr19	37038095	37038095	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaagtctaaagaactttccAcactccttacattcataagg	14	12	5	10	0	2	1	1	0	1	1	4	1	4	1	2	1	2	1	2	1	6	6			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr19:37038095A>G	uc002oeh.3	-	5	1567	c.1365T>C	c.(1363-1365)TGT>TGC	p.C455C	ZNF529_uc010xth.1_Silent_p.C455C|ZNF529_uc010xti.1_Silent_p.C437C|ZNF529_uc002oeg.3_Silent_p.C350C	NM_020951	NP_066002	Q6P280	ZN529_HUMAN	zinc finger protein 529 isoform a	422	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					AGAACTTTCCACACTCCTTAC	0.368													25	76					0	0	0	0	G	37038095	G	G	37038095	2	3	43	1	0	0	0	0	0	0	0	1	18037	157	6	5		5	ZNF529	19	37038095	Silent	SNP	A	TCGA-CN-4731-01A-01D-1434-08	19626068	37038095	22090888	124	9160											
ZNF546	339327	broad.mit.edu	37	chr19	40520097	40520097	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctacgagtgtaaggaatgtgGgaaagcctttagtcgtgtta	11	12	13	5	2	0	0	0	0	0	0	1	3	0	2	1	2	2	2	1	2	6	5			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr19:40520097G>A	uc002oms.2	+	7	1176	c.920G>A	c.(919-921)GGG>GAG	p.G307E	ZNF546_uc002omt.2_Missense_Mutation_p.G281E	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	307	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AAGGAATGTGGGAAAGCCTTT	0.408													71	158					0	0	0	0	A	40520097	A	A	40520097	3	1	43	1	0	0	0	0	1	0	0	0	18045	1232	43	4	938	4	ZNF546	19	40520097	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	3482002	40520097	18608886	125	9161											
LILRA2	11027	broad.mit.edu	37	chr19	55087422	55087422	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccatcccccactgcatctGagatcagagcaccaagctca	11	6	8	16	0	3	2	2	1	1	2	4	3	4	2	4	1	3	3	4	1	1	0			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr19:55087422G>T	uc002qgg.3	+	6	1190	c.1101G>T	c.(1099-1101)CTG>CTT	p.L367L	LILRA2_uc010ern.2_Silent_p.L367L|LILRA2_uc002qgf.2_Silent_p.L367L|LILRA2_uc010yfe.1_Silent_p.L367L|LILRA2_uc010yff.1_Silent_p.L355L|LILRA2_uc010ero.2_Silent_p.L355L|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	367	Ig-like C2-type 4.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CACTGCATCTGAGATCAGAGC	0.587													52	82					4.33383e-22	4.76111e-22	1	0	T	55087422	T	T	55087422	2	4	43	1	0	0	0	0	0	0	0	1	8826	1277	45	2		2	LILRA2	19	55087422	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	14567325	55087422	4041561	126	9162											
NCR1	9437	broad.mit.edu	37	chr19	55417683	55417683	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgagtcagaggatcagcGcccagcagcgtgagtccttc	8	8	13	12	2	3	3	2	2	1	1	5	4	4	4	2	1	3	1	2	1	0	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr19:55417683G>A	uc002qib.2	+	2	99	c.61G>A	c.(61-63)GCC>ACC	p.A21T	NCR1_uc002qic.2_Missense_Mutation_p.A21T|NCR1_uc002qie.2_Missense_Mutation_p.A21T|NCR1_uc002qid.2_Missense_Mutation_p.A21T|NCR1_uc002qif.2_Missense_Mutation_p.A21T|NCR1_uc010esj.2_Intron	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	21					cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		GAGGATCAGCGCCCAGCAGCG	0.612													32	56					0	0	0	0	A	55417683	A	A	55417683	3	1	43	1	0	0	0	0	1	0	0	0	10291	1087	38	1	67	1	NCR1	19	55417683	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08	330261	55417683	3711300	127	9163											
ZNF549	256051	broad.mit.edu	37	chr19	58048899	58048900	+	Frame_Shift_Del	DEL	CT	-	-																															tctgaatagctgcaaaattcCtctgtcagacaatcttttcc																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr19:58048899_58048900delCT	uc002qpb.1	+	4	776_777	c.527_528delCT	c.(526-528)CCTfs	p.P176fs	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Frame_Shift_Del_p.P163fs	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGCAAAATTCCTCTGTCAGACA	0.475													---	---	---								-	58048900	-	-	58048899	7	5	43	1	0	1	0	1	0	0	0	0	18048	681	24	0	498	0	ZNF549	19	58048899	Frame_Shift_Del	DEL	CT	TCGA-CN-4731-01A-01D-1434-08	2631216	58048899	1080084	128	9164											
ISM1	140862	broad.mit.edu	37	chr20	13251361	13251361	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccagatctttccaaagctGatatcaatgggcagaatcca	13	11	7	10	0	2	3	1	1	1	2	5	3	5	3	3	1	1	2	3	1	4	3			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr20:13251361G>C	uc010gce.1	+	2	355	c.349G>C	c.(349-351)GAT>CAT	p.D117H	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	117						extracellular region					0						TTCCAAAGCTGATATCAATGG	0.443													7	45					0	0	0	0	C	13251361	C	C	13251361	3	2	43	1	0	0	0	0	1	0	0	0	7899	1290	45	2	355	2	ISM1	20	13251361	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08		13251361	49774159	129	9165											
PYGB	5834	broad.mit.edu	37	chr20	25262777	25262777	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggggctggccgataccatCgtggaggtgagtcccgggcc	5	6	17	13	4	0	1	0	1	0	0	2	3	1	2	5	6	1	1	5	6	1	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr20:25262777C>A	uc002wup.2	+	12	1621	c.1512C>A	c.(1510-1512)ATC>ATA	p.I504I		NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	504					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	CCGATACCATCGTGGAGGTGA	0.622													5	47					0.000673444	0.00068219	1	0	A	25262777	A	A	25262777	2	1	43	1	0	0	0	0	0	0	0	1	12925	874	31	3		3	PYGB	20	25262777	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	12011416	25262777	37762743	130	9166											
TTLL9	164395	broad.mit.edu	37	chr20	30497542	30497542	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccttcccgccacccagctGacccggaagaactacatggt	9	7	9	16	2	0	2	0	1	0	1	2	3	2	3	5	2	3	1	5	2	3	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr20:30497542G>T	uc010gdx.1	+	6	574	c.321G>T	c.(319-321)CTG>CTT	p.L107L	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_RNA|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Intron|TTLL9_uc010ztp.1_RNA|TTLL9_uc010ztq.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	107	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CCACCCAGCTGACCCGGAAGA	0.632													16	53					1.5739e-10	1.63685e-10	1	0	T	30497542	T	T	30497542	2	4	43	1	0	0	0	0	0	0	0	1	16802	1277	45	2		2	TTLL9	20	30497542	Silent	SNP	G	TCGA-CN-4731-01A-01D-1434-08	5234765	30497542	32527978	131	9167											
KCNS1	3787	broad.mit.edu	37	chr20	43726837	43726837	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgcgccgcgccatagcgCgccagttctcgctgcacgtc	5	6	12	18	8	1	0	0	0	1	0	3	0	1	0	3	0	3	3	3	0	1	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr20:43726837C>T	uc002xnc.2	-	4	973	c.576G>A	c.(574-576)GCG>GCA	p.A192A	KCNS1_uc002xnd.2_Silent_p.A192A	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	192	Cytoplasmic (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)				CGCCATAGCGCGCCAGTTCTC	0.716													7	24					0	0	0	0	T	43726837	T	T	43726837	2	4	43	1	0	0	0	0	0	0	0	1	8127	755	27	1		1	KCNS1	20	43726837	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	13229295	43726837	19298683	132	9168											
EEF1A2	1917	broad.mit.edu	37	chr20	62126260	62126264	+	Frame_Shift_Del	DEL	TTCCT	-	-																															ttcttgatgtaggcgctgacTtccttgacgatctcgtcgta																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr20:62126260_62126264delTTCCT	uc002yfd.1	-	3	616_620	c.515_519delAGGAA	c.(514-519)AAGGAAfs	p.K172fs	EEF1A2_uc002yfe.1_Frame_Shift_Del_p.K172fs|EEF1A2_uc010gkg.1_Frame_Shift_Del_p.K172fs	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	172_173						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			AGGCGCTGACTTCCTTGACGATCTC	0.605													---	---	---								-	62126264	-	-	62126260	7	5	43	1	0	1	0	1	0	0	0	0	4946	1606	56	0	892	0	EEF1A2	20	62126260	Frame_Shift_Del	DEL	TTCCT	TCGA-CN-4731-01A-01D-1434-08	18399423	62126260	899260	133	9169											
EMID1	129080	broad.mit.edu	37	chr22	29654896	29654896	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggacatgcaaccaactaccGgatcgtggcccccaggagcc	10	4	11	16	3	0	0	0	0	0	0	1	3	0	3	5	4	5	1	5	4	3	1	rs138347786		TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr22:29654896G>A	uc003aen.2	+	15	1364	c.1289G>A	c.(1288-1290)CGG>CAG	p.R430Q	EMID1_uc003aem.2_Missense_Mutation_p.R432Q|EMID1_uc003aeo.2_Missense_Mutation_p.R434Q|EMID1_uc003aep.2_Missense_Mutation_p.R411Q	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	EMI domain containing 1	430						collagen					0						ACCAACTACCGGATCGTGGCC	0.716													23	47					0	0	0	0	A	29654896	A	A	29654896	3	1	43	1	0	0	0	0	1	0	0	0	5115	1116	39	1	1353	1	EMID1	22	29654896	Missense_Mutation	SNP	G	TCGA-CN-4731-01A-01D-1434-08		29654896	21649670	134	9170											
LARGE	9215	broad.mit.edu	37	chr22	34046371	34046371	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcgcatttctccacgacCggctgctgcccacactcgga	7	8	8	18	4	1	0	0	0	1	0	4	2	1	1	4	2	2	3	4	2	0	1	rs114558328	by1000genomes	TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr22:34046371C>A	uc003and.3	-	4	969	c.390G>T	c.(388-390)CCG>CCT	p.P130P	LARGE_uc003ane.3_Silent_p.P130P|LARGE_uc010gwp.2_Silent_p.P130P|LARGE_uc011ame.1_Silent_p.P62P|LARGE_uc011amf.1_Silent_p.P130P	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	130	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				TCTCCACGACCGGCTGCTGCC	0.597													52	143					2.165e-29	2.44739e-29	1	0	A	34046371	A	A	34046371	2	1	43	1	0	0	0	0	0	0	0	1	8667	639	23	3		3	LARGE	22	34046371	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	4391475	34046371	17258195	135	9171											
CSF2RB	1439	broad.mit.edu	37	chr22	37325494	37325494	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcagcaccgaccaggaccacTtcctgctgacctggagtgtg	8	8	11	14	1	1	1	1	1	0	0	2	4	2	3	5	2	2	2	5	2	0	1			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr22:37325494T>A	uc003aqa.3	+	5	659	c.442T>A	c.(442-444)TTC>ATC	p.F148I	CSF2RB_uc003aqc.3_Missense_Mutation_p.F148I	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	148	Fibronectin type-III 1.|Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	CCAGGACCACTTCCTGCTGAC	0.637													99	184					0	0	0	0	A	37325494	A	A	37325494	3	1	43	1	0	0	0	0	1	0	0	0	3952	1609	56	5	456	5	CSF2RB	22	37325494	Missense_Mutation	SNP	T	TCGA-CN-4731-01A-01D-1434-08	3279123	37325494	13979072	136	9172											
CACNA1I	8911	broad.mit.edu	37	chr22	39966292	39966293	+	5'Flank	INS	-	CTTT	CTTT																															cttccttccttccttcctttINScttccctccctccctccctc																								rs79667550		TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr22:39966292_39966293insCTTT	uc003ayc.2	+						CACNA1I_uc003ayd.2_5'Flank	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,						axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	ttccttcctttcttccctccct	0.129													---	---	---								CTTT	39966293	CTTT	CTTT	39966292	6	5	43	0	1	1	1	0	0	0	0	0	2558	1798	62	0		0	CACNA1I	22	39966292	5'Flank	INS	-	TCGA-CN-4731-01A-01D-1434-08	2640798	39966292	11338274	137	9173											
MEI1	150365	broad.mit.edu	37	chr22	42180639	42180639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cttatgcttcctgcggacagCcctgcgacaaagcttttcct	7	12	8	14	2	0	0	0	0	0	0	2	2	2	1	3	1	5	2	3	1	2	4			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chr22:42180639C>T	uc003baz.1	+	26	3222	c.3197C>T	c.(3196-3198)GCC>GTC	p.A1066V	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Missense_Mutation_p.A452V|MEI1_uc003bbc.1_Missense_Mutation_p.A434V|MEI1_uc010gym.1_Missense_Mutation_p.A399V|MEI1_uc003bbd.1_Missense_Mutation_p.A309V|MEI1_uc010gyn.1_Intron|MEI1_uc003bbe.1_RNA|MEI1_uc011apf.1_Missense_Mutation_p.A80V|MEI1_uc010gyo.1_Intron|MEI1_uc003bbf.2_Missense_Mutation_p.A80V|MEI1_uc003bbg.2_Missense_Mutation_p.A80V	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	1066							binding			central_nervous_system(1)|skin(1)	2						CTGCGGACAGCCCTGCGACAA	0.597													3	60					0	0	0	0	T	42180639	T	T	42180639	3	4	43	1	0	0	0	0	1	0	0	0	9518	739	26	4	3299	4	MEI1	22	42180639	Missense_Mutation	SNP	C	TCGA-CN-4731-01A-01D-1434-08	2214347	42180639	9123927	138	9174											
FAM120C	54954	broad.mit.edu	37	chrX	54209173	54209190	+	In_Frame_Del	DEL	CAGCGCTGACAAGTAGCC	-	-																															ggataggcacaagcctggcaCagcgctgacaagtagcccag																										TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chrX:54209173_54209190delCAGCGCTGACAAGTAGCC	uc004dsz.3	-	1	525_542	c.442_459delGGCTACTTGTCAGCGCTG	c.(442-459)GGCTACTTGTCAGCGCTGdel	p.GYLSAL148del	FAM120C_uc011moh.1_In_Frame_Del_p.GYLSAL148del|FAM120C_uc004dta.2_In_Frame_Del_p.GYLSAL148del	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	148_153										ovary(1)|central_nervous_system(1)	2						AAGCCTGGCACAGCGCTGACAAGTAGCCCAGCATGGCG	0.711													---	---	---								-	54209190	-	-	54209173	7	5	43	1	0	1	0	1	0	0	0	0	5446	465	17	0	2917	0	FAM120C	23	54209173	In_Frame_Del	DEL	CAGCGCTGACAAGTAGCC	TCGA-CN-4731-01A-01D-1434-08		54209173	101061387	139	9175											
PDZD11	51248	broad.mit.edu	37	chrX	69507978	69507978	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cataaataccttggagatgaAgatgcctagctgggaggcct	12	9	12	8	0	0	3	0	1	0	2	0	5	0	4	3	3	3	1	3	3	5	4			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chrX:69507978A>C	uc004dyd.1	-	4	319	c.217T>G	c.(217-219)TTC>GTC	p.F73V	KIF4A_uc004dyg.2_5'Flank|KIF4A_uc010nkw.2_5'Flank|PDZD11_uc004dye.1_Missense_Mutation_p.F105V|KIF4A_uc004dyf.1_5'Flank	NM_016484	NP_057568	Q5EBL8	PDZ11_HUMAN	PDZ domain containing 11	73	PDZ.					basolateral plasma membrane|cytosol|extracellular region	protein C-terminus binding				0						TTGGAGATGAAGATGCCTAGC	0.463													15	19					0	0	0	0	C	69507978	C	C	69507978	3	2	43	1	0	0	0	0	1	0	0	0	11754	72	3	5	221	5	PDZD11	23	69507978	Missense_Mutation	SNP	A	TCGA-CN-4731-01A-01D-1434-08	15298805	69507978	85762582	140	9176											
SLC6A8	6535	broad.mit.edu	37	chrX	152956769	152956769	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccggccccaggcctgggctaCgcctccatggtgatcgtctt	4	9	12	16	3	1	1	0	1	1	0	3	1	2	1	6	4	1	1	6	4	1	2			TCGA-CN-4731-01A-01D-1434-08	TCGA-CN-4731-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	31ffd2d8-ee97-4002-9737-08c044878ace	ebb2ea32-6180-4d55-9dbf-740affddc084	g.chrX:152956769C>T	uc004fib.3	+	3	683	c.405C>T	c.(403-405)TAC>TAT	p.Y135Y	SLC6A8_uc004fic.3_Silent_p.Y135Y|SLC6A8_uc011myx.1_Silent_p.Y20Y|SLC6A8_uc010nuj.2_5'Flank|SLC6A8_uc010nui.1_Silent_p.Y20Y	NM_005629	NP_005620	P48029	SC6A8_HUMAN	solute carrier family 6 member 8 isoform 1	135	Cytoplasmic (Potential).				creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	GCCTGGGCTACGCCTCCATGG	0.602													3	25					0	0	0	0	T	152956769	T	T	152956769	2	4	43	1	0	0	0	0	0	0	0	1	14754	547	19	1		1	SLC6A8	23	152956769	Silent	SNP	C	TCGA-CN-4731-01A-01D-1434-08	83448791	152956769	2313791	141	9177											
C1orf158	93190	broad.mit.edu	37	chr1	12819314	12819314	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgatcagcacctatgaCgaccattacaaccggcatgg	12	8	8	13	2	1	2	1	2	0	0	1	3	1	2	4	2	4	2	4	2	4	3			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:12819314C>T	uc001auh.2	+	3	513	c.297C>T	c.(295-297)GAC>GAT	p.D99D	C1orf158_uc010obe.1_Silent_p.D99D	NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	99										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GCACCTATGACGACCATTACA	0.567													9	175					0	0	0	0	T	12819314	T	T	12819314	2	4	44	1	0	0	0	0	0	0	0	1	2016	535	19	1		1	C1orf158	1	12819314	Silent	SNP	C	TCGA-CN-4733-01A-02D-1870-08		12819314	236431307	1	9178											
TAS1R2	80834	broad.mit.edu	37	chr1	19166791	19166791	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgccaccagcagcagtgtcaGcatcaggaagcacatggggc	11	5	13	12	0	2	0	2	0	0	0	2	1	2	1	2	3	5	4	2	3	1	0			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:19166791G>A	uc001bba.1	-	6	1823	c.1822C>T	c.(1822-1824)CTG>TTG	p.L608L		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	608	Helical; Name=2; (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	AGCAGTGTCAGCATCAGGAAG	0.632													4	96					0	0	0	0	A	19166791	A	A	19166791	2	1	44	1	0	0	0	0	0	0	0	1	15629	962	34	4		4	TAS1R2	1	19166791	Silent	SNP	G	TCGA-CN-4733-01A-02D-1870-08	6347477	19166791	230083830	2	9179											
EIF4G3	8672	broad.mit.edu	37	chr1	21191633	21191633	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggcagcctcaagttctttCtgcttcttctcaaagacatc	8	14	6	13	0	5	1	2	0	4	1	7	1	5	1	1	1	2	3	1	1	2	4			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:21191633C>G	uc001bec.2	-	16	2833	c.2577G>C	c.(2575-2577)CAG>CAC	p.Q859H	EIF4G3_uc010odi.1_Missense_Mutation_p.Q463H|EIF4G3_uc010odj.1_Missense_Mutation_p.Q858H|EIF4G3_uc009vpz.2_Missense_Mutation_p.Q579H|EIF4G3_uc001bed.2_Missense_Mutation_p.Q859H|EIF4G3_uc001bef.2_Missense_Mutation_p.Q895H|EIF4G3_uc001bee.2_Missense_Mutation_p.Q865H	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	859	eIF3/EIF4A-binding (By similarity).|MIF4G.|HEAT 3.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CAAGTTCTTTCTGCTTCTTCT	0.408													3	109					0	0	0	0	G	21191633	G	G	21191633	3	3	44	1	0	0	0	0	1	0	0	0	5062	912	32	2	2248	2	EIF4G3	1	21191633	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08	2024842	21191633	228058988	3	9180											
ARID1A	8289	broad.mit.edu	37	chr1	27089711	27089711	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgtcccccaccagggggCatgaaccggaaaacccaaga	13	4	11	13	1	0	2	0	1	0	1	1	3	1	3	5	3	2	1	5	3	4	0			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:27089711C>T	uc001bmv.1	+	8	3040	c.2667C>T	c.(2665-2667)GGC>GGT	p.G889G	ARID1A_uc001bmt.1_Silent_p.G889G|ARID1A_uc001bmu.1_Silent_p.G889G|ARID1A_uc001bmw.1_Silent_p.G506G	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	889					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CACCAGGGGGCATGAACCGGA	0.567			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								4	42					0	0	0	0	T	27089711	T	T	27089711	2	4	44	1	0	0	0	0	0	0	0	1	913	697	25	4		4	ARID1A	1	27089711	Silent	SNP	C	TCGA-CN-4733-01A-02D-1870-08	5898078	27089711	222160910	4	9181											
SFRS4	6429	broad.mit.edu	37	chr1	29475489	29475489	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcctcctccactctcctCtcctgactcctgctccgact	3	14	3	21	1	3	1	0	1	3	0	10	2	7	1	7	0	1	1	7	0	0	1			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:29475489C>G	uc001bro.2	-	6	1291	c.918G>C	c.(916-918)GAG>GAC	p.E306D	SFRS4_uc010ofy.1_3'UTR	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	306	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		ccactctcctctcctgactcc	0.189													8	173					0	0	0	0	G	29475489	G	G	29475489	3	3	44	1	0	0	0	0	1	0	0	0	14244	912	32	2	570	2	SFRS4	1	29475489	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08	2385778	29475489	219775132	5	9182											
STIL	6491	broad.mit.edu	37	chr1	47717292	47717292	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtcactgctttgtaggagtCcatatctcttcatatatttt	8	19	6	8	0	3	0	2	0	1	0	5	1	4	1	1	1	1	2	1	1	4	8			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:47717292C>A	uc001crc.1	-	17	3535	c.3380G>T	c.(3379-3381)GGA>GTA	p.G1127V	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.G1081V|STIL_uc010omo.1_Missense_Mutation_p.G1110V|STIL_uc001crd.1_Missense_Mutation_p.G1128V|STIL_uc001cre.1_Missense_Mutation_p.G1127V	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1127					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TTGTAGGAGTCCATATCTCTT	0.378													7	164					0.00198382	0.00209403	1	0	A	47717292	A	A	47717292	3	1	44	1	0	0	0	0	1	0	0	0	15348	855	30	2	487	2	STIL	1	47717292	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08	18241803	47717292	201533329	6	9183											
SMG5	23381	broad.mit.edu	37	chr1	156237465	156237465	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggtcagctctgagtccaCggagctacagaggggcagga	10	6	16	9	1	2	3	1	2	1	1	3	5	3	5	1	5	3	3	1	5	1	1			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:156237465C>T	uc001foc.3	-	10	1062	c.913G>A	c.(913-915)GTG>ATG	p.V305M	SMG5_uc009wrv.2_5'Flank	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	305					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					TCTGAGTCCACGGAGCTACAG	0.572													3	11					0	0	0	0	T	156237465	T	T	156237465	3	4	44	1	0	0	0	0	1	0	0	0	14860	536	19	1	2189	1	SMG5	1	156237465	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08	108520173	156237465	93013156	7	9184											
PRKCE	5581	broad.mit.edu	37	chr2	46203655	46203655	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcgcagggtccatcaggTcaacggccacaagttcatgg	10	6	13	12	2	3	0	3	0	0	0	4	0	4	0	2	5	1	2	2	5	2	1			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr2:46203655T>G	uc002rut.2	+	3	697	c.500T>G	c.(499-501)GTC>GGC	p.V167G		NM_005400	NP_005391	Q02156	KPCE_HUMAN	protein kinase C, epsilon	167					activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity			lung(4)|ovary(3)|kidney(1)|breast(1)|large_intestine(1)	10		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			GTCCATCAGGTCAACGGCCAC	0.577													6	72					0	0	0	0	G	46203655	G	G	46203655	3	3	44	1	0	0	0	0	1	0	0	0	12573	1667	58	5	510	5	PRKCE	2	46203655	Missense_Mutation	SNP	T	TCGA-CN-4733-01A-02D-1870-08		46203655	196995718	8	9185											
XIRP2	129446	broad.mit.edu	37	chr2	168100193	168100193	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcacagagaagacgttgaaaAgggagatgtaagaacagcac	18	5	12	6	1	1	5	1	1	0	4	1	7	1	5	0	1	2	3	0	1	5	2			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr2:168100193A>G	uc002udx.2	+	8	2309	c.2291A>G	c.(2290-2292)AAG>AGG	p.K764R	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.K589R|XIRP2_uc010fpq.2_Missense_Mutation_p.K542R|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	589					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GACGTTGAAAAGGGAGATGTA	0.373													3	60					0	0	0	0	G	168100193	G	G	168100193	3	3	44	1	0	0	0	0	1	0	0	0	17498	72	3	5	2321	5	XIRP2	2	168100193	Missense_Mutation	SNP	A	TCGA-CN-4733-01A-02D-1870-08	121896538	168100193	75099180	9	9186											
TTLL3	26140	broad.mit.edu	37	chr3	9860559	9860559	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaagctggtggtgaagtctGagtggaagtcataccctatt	10	12	12	7	0	3	2	2	2	1	0	3	3	3	3	1	3	2	1	1	3	5	3			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr3:9860559G>C	uc003btg.2	+	6	700	c.484G>C	c.(484-486)GAG>CAG	p.E162Q	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_Intron|TTLL3_uc003btf.3_5'UTR|TTLL3_uc010hco.1_Missense_Mutation_p.E98Q|TTLL3_uc003bth.3_5'UTR|TTLL3_uc011atj.1_Missense_Mutation_p.E98Q|TTLL3_uc003btj.3_5'UTR|TTLL3_uc003bti.3_5'UTR	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	162	TTL.				axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					GGTGAAGTCTGAGTGGAAGTC	0.468													6	173					0	0	0	0	C	9860559	C	C	9860559	3	2	44	1	0	0	0	0	1	0	0	0	16796	1291	45	2	502	2	TTLL3	3	9860559	Missense_Mutation	SNP	G	TCGA-CN-4733-01A-02D-1870-08		9860559	188161871	10	9187											
JAKMIP1	152789	broad.mit.edu	37	chr4	6083476	6083476	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacctcggtctctcgtgagcGtttcagctgtggttggaaac	7	12	12	10	3	2	1	1	1	1	0	5	2	2	2	1	3	4	3	1	3	2	2			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr4:6083476G>A	uc003giu.3	-	6	1237	c.961C>T	c.(961-963)CGC>TGC	p.R321C	JAKMIP1_uc010idb.1_Missense_Mutation_p.R321C|JAKMIP1_uc010idc.1_Missense_Mutation_p.R156C|JAKMIP1_uc010idd.1_Missense_Mutation_p.R321C|JAKMIP1_uc011bwc.1_Missense_Mutation_p.R156C|JAKMIP1_uc003giv.3_Missense_Mutation_p.R321C|JAKMIP1_uc010ide.2_Missense_Mutation_p.R321C	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	321	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TCTCGTGAGCGTTTCAGCTGT	0.542													6	70					0	0	0	0	A	6083476	A	A	6083476	3	1	44	1	0	0	0	0	1	0	0	0	7979	1145	40	1	1673	1	JAKMIP1	4	6083476	Missense_Mutation	SNP	G	TCGA-CN-4733-01A-02D-1870-08		6083476	185070800	11	9188											
CSN2	1447	broad.mit.edu	37	chr4	70826811	70826811	+	5'Flank	DEL	A	-	-																															aaggttactttttataaaacAaaaaaaaaagagagataata																										TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr4:70826811delA	uc003hes.3	-						CSN2_uc003het.3_5'Flank	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor						calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						TTTATAAAACAAAAAAAAAAG	0.264													---	---	---								-	70826811	-	-	70826811	6	5	44	0	1	1	0	1	0	0	0	0	3965	145	5	0		0	CSN2	4	70826811	5'Flank	DEL	A	TCGA-CN-4733-01A-02D-1870-08	64743335	70826811	120327465	12	9189											
ANK2	287	broad.mit.edu	37	chr4	114290865	114290865	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctcagagcacagagaggaGagctctccgcggaaaaccag	13	3	12	13	2	2	3	1	0	1	3	3	6	2	4	3	2	3	2	3	2	2	0			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr4:114290865G>A	uc003ibe.3	+	43	11614	c.11514G>A	c.(11512-11514)GAG>GAA	p.E3838E	ANK2_uc003ibd.3_Silent_p.E1744E|ANK2_uc003ibf.3_Silent_p.E1753E|ANK2_uc011cgc.1_Silent_p.E929E|ANK2_uc003ibg.3_Silent_p.E737E|ANK2_uc003ibh.3_Silent_p.E427E|ANK2_uc011cgd.1_Silent_p.E1140E	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3805					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACAGAGAGGAGAGCTCTCCGC	0.542													7	47					0	0	0	0	A	114290865	A	A	114290865	2	1	44	1	0	0	0	0	0	0	0	1	621	933	33	2		2	ANK2	4	114290865	Silent	SNP	G	TCGA-CN-4733-01A-02D-1870-08	43464054	114290865	76863411	13	9190											
FAT4	79633	broad.mit.edu	37	chr4	126241841	126241841	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agctttcctcctggagatatTttcaagtctattgttgagaa	10	16	8	7	0	2	2	1	1	1	2	4	4	4	2	2	1	1	2	2	1	4	7			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr4:126241841T>C	uc003ifj.3	+	1	4275	c.4275T>C	c.(4273-4275)ATT>ATC	p.I1425I		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1425	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGGAGATATTTTCAAGTCTA	0.423													3	157					0	0	0	0	C	126241841	C	C	126241841	2	2	44	1	0	0	0	0	0	0	0	1	5724	1829	64	5		5	FAT4	4	126241841	Silent	SNP	T	TCGA-CN-4733-01A-02D-1870-08	11950976	126241841	64912435	14	9191											
DNAH5	1767	broad.mit.edu	37	chr5	13692178	13692178	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgagatccacagcggcaatgTagttcaagtccgttcgaact	11	10	10	10	3	1	1	1	1	0	1	4	3	3	1	2	1	2	4	2	1	4	3			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr5:13692178T>C	uc003jfd.2	-	79	13832	c.13790A>G	c.(13789-13791)TAC>TGC	p.Y4597C	DNAH5_uc003jfc.2_Missense_Mutation_p.Y765C	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4597					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGCGGCAATGTAGTTCAAGTC	0.483									Kartagener_syndrome				4	76					0	0	0	0	C	13692178	C	C	13692178	3	2	44	1	0	0	0	0	1	0	0	0	4626	1638	57	5	88	5	DNAH5	5	13692178	Missense_Mutation	SNP	T	TCGA-CN-4733-01A-02D-1870-08		13692178	167223082	15	9192											
TDRD6	221400	broad.mit.edu	37	chr6	46661019	46661019	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgactcagagataaagcaGactcttgggtcctacaatct	13	11	8	9	0	3	3	1	1	2	2	4	4	4	3	1	1	2	1	1	1	4	4			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr6:46661019G>A	uc003oyj.2	+	1	5154	c.5154G>A	c.(5152-5154)CAG>CAA	p.Q1718Q	TDRD6_uc010jze.2_Silent_p.Q1712Q	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1718					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AGATAAAGCAGACTCTTGGGT	0.318													3	59					0	0	0	0	A	46661019	A	A	46661019	2	1	44	1	0	0	0	0	0	0	0	1	15800	933	33	2		2	TDRD6	6	46661019	Silent	SNP	G	TCGA-CN-4733-01A-02D-1870-08		46661019	124454048	16	9193											
NAPEPLD	222236	broad.mit.edu	37	chr7	102760426	102760426	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggttgtgactgataaggaccGcatctattggagggagttca	10	11	14	6	1	2	2	1	2	1	0	2	5	2	5	1	4	0	3	1	4	2	5			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr7:102760426G>A	uc003vbc.2	-	3	867	c.539C>T	c.(538-540)GCG>GTG	p.A180V	NAPEPLD_uc003vbd.2_Missense_Mutation_p.A180V|NAPEPLD_uc011klj.1_Missense_Mutation_p.A253V|NAPEPLD_uc003vbe.2_RNA	NM_198990	NP_945341	Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	180					phospholipid catabolic process	membrane	metal ion binding			skin(1)	1						GATAAGGACCGCATCTATTGG	0.463													4	157					0	0	0	0	A	102760426	A	A	102760426	3	1	44	1	0	0	0	0	1	0	0	0	10216	1087	38	1	654	1	NAPEPLD	7	102760426	Missense_Mutation	SNP	G	TCGA-CN-4733-01A-02D-1870-08		102760426	56378237	17	9194											
PAPPA	5069	broad.mit.edu	37	chr9	119124919	119124919	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaagatggcacctggaacGgctccttccatgtctgccag	9	8	12	12	1	1	1	0	0	1	1	3	3	3	3	4	4	2	2	4	4	2	1			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr9:119124919G>A	uc004bjn.2	+	18	4777	c.4396G>A	c.(4396-4398)GGC>AGC	p.G1466S	PAPPA_uc011lxq.1_Missense_Mutation_p.G841S	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1466	Sushi 4.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CACCTGGAACGGCTCCTTCCA	0.532													4	104					0	0	0	0	A	119124919	A	A	119124919	3	1	44	1	0	0	0	0	1	0	0	0	11486	1116	39	1	4466	1	PAPPA	9	119124919	Missense_Mutation	SNP	G	TCGA-CN-4733-01A-02D-1870-08		119124919	22088512	18	9195											
OR5D16	390144	broad.mit.edu	37	chr11	55606601	55606601	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtgatggcctatgaccactTtgtggccatttgcaatcctc	7	13	10	11	0	0	2	0	2	0	0	2	2	1	2	4	3	1	1	4	3	2	3			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr11:55606601T>C	uc010rio.1	+	1	374	c.374T>C	c.(373-375)TTT>TCT	p.F125S		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TATGACCACTTTGTGGCCATT	0.443													4	123					0	0	0	0	C	55606601	C	C	55606601	3	2	44	1	0	0	0	0	1	0	0	0	11210	1841	64	5	376	5	OR5D16	11	55606601	Missense_Mutation	SNP	T	TCGA-CN-4733-01A-02D-1870-08		55606601	79399915	19	9196											
DDX6	1656	broad.mit.edu	37	chr11	118625459	118625459	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacaggctcgctgtggtattCtgccacatacaggctcttat	8	13	9	11	1	2	0	0	0	2	0	3	0	2	0	1	3	3	4	1	3	4	5			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr11:118625459C>G	uc001pub.2	-	13	1775	c.1414G>C	c.(1414-1416)GAA>CAA	p.E472Q	DDX6_uc001pua.2_Missense_Mutation_p.E172Q|DDX6_uc001puc.2_Missense_Mutation_p.E472Q	NM_004397	NP_004388	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	472					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		CTGTGGTATTCTGCCACATAC	0.423			T	IGH@	B-NHL								7	159					0	0	0	0	G	118625459	G	G	118625459	3	3	44	1	0	0	0	0	1	0	0	0	4394	922	32	2	41	2	DDX6	11	118625459	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08	63018858	118625459	16381057	20	9197											
ARHGEF12	23365	broad.mit.edu	37	chr11	120316154	120316154	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaagtttctgttcctgaTgaaatgtctgcagatctagg	10	14	10	7	0	3	4	0	3	3	1	4	4	4	4	1	1	1	3	1	1	3	3			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr11:120316154T>A	uc001pxl.1	+	16	1333	c.1326T>A	c.(1324-1326)GAT>GAA	p.D442E	ARHGEF12_uc009zat.2_Missense_Mutation_p.D423E|ARHGEF12_uc010rzn.1_Missense_Mutation_p.D339E|ARHGEF12_uc009zau.1_Missense_Mutation_p.D339E	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	442	RGSL.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CTGTTCCTGATGAAATGTCTG	0.353			T	MLL	AML								3	86					0	0	0	0	A	120316154	A	A	120316154	3	1	44	1	0	0	0	0	1	0	0	0	897	1461	51	5	1388	5	ARHGEF12	11	120316154	Missense_Mutation	SNP	T	TCGA-CN-4733-01A-02D-1870-08	1690695	120316154	14690362	21	9198											
ERC1	23085	broad.mit.edu	37	chr12	1221439	1221439	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaatgggaggagctgaaaaAgaaagcggctggtcttcagg	13	7	15	6	1	3	2	2	1	1	1	3	4	3	4	0	5	2	2	0	5	4	1			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr12:1221439A>T	uc001qjb.2	+	6	1617	c.1376A>T	c.(1375-1377)AAG>ATG	p.K459M	ERC1_uc001qiz.2_Intron|ERC1_uc001qjc.2_Intron|ERC1_uc001qja.2_Intron|ERC1_uc001qjd.2_Intron|ERC1_uc001qjf.2_Missense_Mutation_p.K459M|ERC1_uc010sdv.1_Intron|ERC1_uc009zdp.2_Missense_Mutation_p.K96M	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	459	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GAGCTGAAAAAGAAAGCGGCT	0.468													7	127					0	0	0	0	T	1221439	T	T	1221439	3	4	44	1	0	0	0	0	1	0	0	0	5234	72	3	5	1394	5	ERC1	12	1221439	Missense_Mutation	SNP	A	TCGA-CN-4733-01A-02D-1870-08		1221439	132630456	22	9199											
CLEC4D	338339	broad.mit.edu	37	chr12	8672931	8672931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagacgccatttaacccacGcagagtgtaagtatattgag	13	9	9	10	2	0	3	0	1	0	2	0	3	0	3	3	0	1	3	3	0	4	6			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr12:8672931G>A	uc001qun.2	+	5	687	c.494G>A	c.(493-495)CGC>CAC	p.R165H		NM_080387	NP_525126	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	165	C-type lectin.|Extracellular (Potential).				innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)					TTTAACCCACGCAGAGTGTAA	0.418													5	78					0	0	0	0	A	8672931	A	A	8672931	3	1	44	1	0	0	0	0	1	0	0	0	3529	1087	38	1	512	1	CLEC4D	12	8672931	Missense_Mutation	SNP	G	TCGA-CN-4733-01A-02D-1870-08	7451492	8672931	125178964	23	9200											
TMPO	7112	broad.mit.edu	37	chr12	98941400	98941400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcaggccggccattagaaCtcagtgatttcaggatggag	10	9	13	9	1	2	2	2	1	0	1	2	4	2	4	2	4	2	1	2	4	2	2			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr12:98941400C>T	uc001tfj.2	+	9	1366	c.1129C>T	c.(1129-1131)CTC>TTC	p.L377F	TMPO_uc001tfk.2_Missense_Mutation_p.L268F|TMPO_uc001tfl.2_RNA	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta	377	Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2						GCCATTAGAACTCAGTGATTT	0.428													6	58					0	0	0	0	T	98941400	T	T	98941400	3	4	44	1	0	0	0	0	1	0	0	0	16303	565	20	4	2687	4	TMPO	12	98941400	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08	90268469	98941400	34910495	24	9201											
SLC17A8	246213	broad.mit.edu	37	chr12	100784777	100784777	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatctgatttctcatttccAgacagcacagtttaactggg	11	14	7	9	0	2	2	1	1	2	1	4	2	3	2	1	1	2	2	1	1	2	5			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr12:100784777A>G	uc010svi.1	+	3	668	c.355_splice	c.e3-2	p.T119_splice	SLC17A8_uc009ztx.2_Splice_Site_p.T119_splice	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent						neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TCTCATTTCCAGACAGCACAG	0.378													8	92					0	0	0	0	G	100784777	G	G	100784777	5	3	44	1	0	0	0	0	0	0	1	0	14488	202	7	5	363	5	SLC17A8	12	100784777	Splice_Site	SNP	A	TCGA-CN-4733-01A-02D-1870-08	1843377	100784777	33067118	25	9202											
SKA3	221150	broad.mit.edu	37	chr13	21729856	21729856	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttctttgttgctgacatctCggatgttctgtccatgttta	5	20	8	8	1	3	1	0	1	3	0	5	2	4	2	1	1	1	4	1	1	1	6			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr13:21729856C>G	uc001unt.2	-	8	1308	c.1214G>C	c.(1213-1215)CGA>CCA	p.R405P	SKA3_uc001unv.2_Missense_Mutation_p.R323P|SKA3_uc001unu.2_Intron	NM_145061	NP_659498	Q8IX90	SKA3_HUMAN	SKA3	405					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding				0						GCTGACATCTCGGATGTTCTG	0.328													8	120					0	0	0	0	G	21729856	G	G	21729856	3	3	44	1	0	0	0	0	1	0	0	0	14419	884	31	3	79	3	SKA3	13	21729856	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08		21729856	93440022	26	9203											
TMEM55B	90809	broad.mit.edu	37	chr14	20928987	20928987	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caacacggctggatgcccctCgggaaacgggggaaatgctg	10	5	15	11	3	0	0	0	0	0	0	1	3	0	3	2	5	4	2	2	5	3	0			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr14:20928987C>G	uc001vxl.2	-	2	313	c.160G>C	c.(160-162)GAG>CAG	p.E54Q	TMEM55B_uc001vxk.2_Missense_Mutation_p.E61Q	NM_144568	NP_653169	Q86T03	TM55B_HUMAN	transmembrane protein 55B isoform 2	54	Pro-rich.					integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		GGATGCCCCTCGGGAAACGGG	0.587													4	96					0	0	0	0	G	20928987	G	G	20928987	3	3	44	1	0	0	0	0	1	0	0	0	16248	893	31	3	697	3	TMEM55B	14	20928987	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08		20928987	86420553	27	9204											
MYH7	4625	broad.mit.edu	37	chr14	23884264	23884264	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgcccttcaccgactctgcGttgcgcttctgctcggcctc	3	12	9	17	4	3	0	1	0	2	0	5	1	3	0	3	1	4	3	3	1	0	3	rs3729831		TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr14:23884264G>A	uc001wjx.2	-	37	5605	c.5499C>T	c.(5497-5499)AAC>AAT	p.N1833N		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1833	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCGACTCTGCGTTGCGCTTCT	0.652													7	154					0	0	0	0	A	23884264	A	A	23884264	2	1	44	1	0	0	0	0	0	0	0	1	10092	1136	40	1		1	MYH7	14	23884264	Silent	SNP	G	TCGA-CN-4733-01A-02D-1870-08	2955277	23884264	83465276	28	9205											
ADCY4	196883	broad.mit.edu	37	chr14	24788554	24788554	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgttgtgcatcctgtccaGaggtggcatttaagcctgtg	6	13	12	10	0	0	1	0	0	0	1	2	1	2	1	4	2	2	3	4	2	1	3			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr14:24788554G>A	uc001wov.2	-	22	2828	c.2822C>T	c.(2821-2823)TCT>TTT	p.S941F	ADCY4_uc001wow.2_Missense_Mutation_p.S941F|ADCY4_uc010toh.1_Missense_Mutation_p.S627F|ADCY4_uc001wox.2_Missense_Mutation_p.S941F|ADCY4_uc001woy.2_Missense_Mutation_p.S941F	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	941	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		ATCCTGTCCAGAGGTGGCATT	0.527													8	78					0	0	0	0	A	24788554	A	A	24788554	3	1	44	1	0	0	0	0	1	0	0	0	296	942	33	2	427	2	ADCY4	14	24788554	Missense_Mutation	SNP	G	TCGA-CN-4733-01A-02D-1870-08	904290	24788554	82560986	29	9206											
SYNE2	23224	broad.mit.edu	37	chr14	64656947	64656947	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caacatctttttgatgtcatCggatcaaggtaagaaatggg	13	12	10	6	1	3	2	2	1	1	1	4	3	3	3	0	3	1	1	0	3	4	3	rs145549349	by1000genomes	TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr14:64656947C>T	uc001xgm.2	+	99	18260	c.18030C>T	c.(18028-18030)ATC>ATT	p.I6010I	SYNE2_uc001xgl.2_Silent_p.I6010I|SYNE2_uc010apy.2_Silent_p.I2395I|SYNE2_uc001xgn.2_Silent_p.I972I|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Intron|SYNE2_uc001xgq.2_Silent_p.I375I	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6010	Spectrin 5.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTGATGTCATCGGATCAAGGT	0.403													4	48					0	0	0	0	T	64656947	T	T	64656947	2	4	44	1	0	0	0	0	0	0	0	1	15512	874	31	1		1	SYNE2	14	64656947	Silent	SNP	C	TCGA-CN-4733-01A-02D-1870-08	39868393	64656947	42692593	30	9207											
GOLGA6C	653641	broad.mit.edu	37	chr15	75562493	75562493	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gttctccccatgacaaccccCcggtacagcagatcgtgcag	9	7	9	16	2	1	2	0	1	1	1	3	2	1	2	5	1	4	4	5	1	2	2			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr15:75562493C>A	uc002azs.1	+	18	2076	c.1999C>A	c.(1999-2001)CCG>ACG	p.P667T	uc002azu.1_5'Flank|uc010ulz.1_5'Flank	NM_001145224	NP_001138696	A6NDK9	GOG6C_HUMAN	golgi autoantigen, golgin subfamily a, 6D	679										ovary(1)	1						TGACAACCCCCCGGTACAGCA	0.602													5	107					1.024e-07	1.10128e-07	1	0	A	75562493	A	A	75562493	3	1	44	1	0	0	0	0	1	0	0	0	6596	623	22	4	2105	4	GOLGA6C	15	75562493	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08		75562493	26968899	31	9208											
FES	2242	broad.mit.edu	37	chr15	91433125	91433125	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgagatggtgttcaggcggCaggagatggttacgcagctg	8	8	17	8	3	1	2	1	0	0	2	1	4	1	2	1	5	2	5	1	5	1	2			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr15:91433125C>T	uc002bpv.2	+	8	1078	c.982C>T	c.(982-984)CAG>TAG	p.Q328*	FES_uc010uqj.1_Nonsense_Mutation_p.Q270*|FES_uc010uqk.1_Nonsense_Mutation_p.Q310*|FES_uc002bpw.2_RNA|FES_uc010bny.2_Nonsense_Mutation_p.Q270*|FES_uc002bpx.2_Nonsense_Mutation_p.Q328*|FES_uc002bpy.2_Nonsense_Mutation_p.Q270*	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	328	Potential.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GTTCAGGCGGCAGGAGATGGT	0.637													6	142					0	0	0	0	T	91433125	T	T	91433125	4	4	44	1	0	0	0	0	0	1	0	0	5852	711	25	4	1008	4	FES	15	91433125	Nonsense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08	15870632	91433125	11098267	32	9209											
KIAA0430	9665	broad.mit.edu	37	chr16	15718917	15718917	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctgccacccccgagtttttCggcgtcgacactgcagcact	6	10	9	16	4	1	0	0	0	1	0	3	2	1	0	3	1	3	3	3	1	0	2			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr16:15718917C>T	uc002ddr.2	-	9	2260	c.2067G>A	c.(2065-2067)CCG>CCA	p.P689P	KIAA0430_uc002ddq.2_Silent_p.P545P|KIAA0430_uc010uzv.1_Silent_p.P685P|KIAA0430_uc010uzw.1_Silent_p.P687P	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	688						peroxisome	nucleotide binding|RNA binding				0						CCGAGTTTTTCGGCGTCGACA	0.483													12	116					0	0	0	0	T	15718917	T	T	15718917	2	4	44	1	0	0	0	0	0	0	0	1	8216	871	31	1		1	KIAA0430	16	15718917	Silent	SNP	C	TCGA-CN-4733-01A-02D-1870-08		15718917	74635836	33	9210											
PRSS54	221191	broad.mit.edu	37	chr16	58319891	58319892	+	Frame_Shift_Del	DEL	GT	-	-																															gcagttctgcaagactggtgGtgtatgcagcattctgccga																										TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr16:58319891_58319892delGT	uc002enf.2	-	5	866_867	c.471_472delAC	c.(469-474)ACACCAfs	p.T157fs	PRSS54_uc002eng.2_Frame_Shift_Del_p.T157fs|PRSS54_uc010vie.1_Frame_Shift_Del_p.T58fs	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	157_158	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						AAGACTGGTGGTGTATGCAGCA	0.545													---	---	---								-	58319892	-	-	58319891	7	5	44	1	0	1	0	1	0	0	0	0	12695	1261	44	0	727	0	PRSS54	16	58319891	Frame_Shift_Del	DEL	GT	TCGA-CN-4733-01A-02D-1870-08	42600974	58319891	32034862	34	9211											
ZNF821	55565	broad.mit.edu	37	chr16	71898871	71898871	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctaactctttctccacttTgaccacccctccatcttcct	6	16	1	18	0	4	1	0	1	4	0	7	1	6	1	6	0	1	0	6	0	1	5			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr16:71898871T>A	uc010vmj.1	-	4	623	c.247A>T	c.(247-249)AAA>TAA	p.K83*	ATXN1L_uc010vmi.1_Intron|ZNF821_uc002fbe.2_5'UTR|ZNF821_uc002fbf.2_Nonsense_Mutation_p.K41*|ZNF821_uc002fbg.3_Intron|ZNF821_uc002fbh.3_Nonsense_Mutation_p.K41*|ZNF821_uc002fbi.3_5'UTR	NM_017530	NP_060000	O75541	ZN821_HUMAN	zinc finger protein 821	83					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTCTCCACTTTGACCACCCCT	0.522													11	124					0	0	0	0	A	71898871	A	A	71898871	4	1	44	1	0	0	0	0	0	1	0	0	18245	1821	63	5	1007	5	ZNF821	16	71898871	Nonsense_Mutation	SNP	T	TCGA-CN-4733-01A-02D-1870-08	13578980	71898871	18455882	35	9212											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	12	6	8	15	2	1	0	1	0	0	0	3	1	3	1	3	2	2	4	3	2	2	1	rs28934576	by1000genomes	TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	22					0	0	0	0	T	7577120	T	T	7577120	3	4	44	1	0	0	0	0	1	0	0	0	16448	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08		7577120	73618090	36	9213											
COASY	80347	broad.mit.edu	37	chr17	40716511	40716511	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccagctgctgaaggacctCagacatacagagaatgaaga	16	6	10	9	0	1	5	1	2	0	3	2	7	2	6	2	1	3	2	2	1	4	1			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr17:40716511C>G	uc002hzz.2	+	4	1120	c.963C>G	c.(961-963)CTC>CTG	p.L321L	COASY_uc010cyj.2_Silent_p.L350L|COASY_uc002iab.2_Silent_p.L26L|COASY_uc002iad.2_Silent_p.L321L|COASY_uc002iac.2_Silent_p.L321L|COASY_uc002iae.2_Silent_p.L116L|MLX_uc002iaf.2_5'Flank|MLX_uc002iag.2_5'Flank|MLX_uc002iah.2_5'Flank	NM_001042529	NP_001035994	Q13057	COASY_HUMAN	coenzyme A synthase isoform a	321	Phosphopantetheine adenylyltransferase.				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity				0		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		TGAAGGACCTCAGACATACAG	0.527													4	70					0	0	0	0	G	40716511	G	G	40716511	2	3	44	1	0	0	0	0	0	0	0	1	3667	813	29	2		2	COASY	17	40716511	Silent	SNP	C	TCGA-CN-4733-01A-02D-1870-08	33139391	40716511	40478699	37	9214											
TTLL6	284076	broad.mit.edu	37	chr17	46847448	46847448	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gattctggggtggtttctacGgaggttaagtgctggaagaa	9	12	16	4	1	2	1	0	0	2	1	2	4	2	3	0	6	2	3	0	6	4	4			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr17:46847448G>A	uc010wlo.1	-	15	2087	c.2052C>T	c.(2050-2052)TCC>TCT	p.S684S	TTLL6_uc002iob.2_Silent_p.S377S|TTLL6_uc010dbi.2_Intron|TTLL6_uc002ioc.2_Silent_p.S437S|TTLL6_uc002iod.2_Intron	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	636						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						TGGTTTCTACGGAGGTTAAGT	0.443													8	91					0	0	0	0	A	46847448	A	A	46847448	2	1	44	1	0	0	0	0	0	0	0	1	16799	1103	39	1		1	TTLL6	17	46847448	Silent	SNP	G	TCGA-CN-4733-01A-02D-1870-08	6130937	46847448	34347762	38	9215											
CHAD	1101	broad.mit.edu	37	chr17	48545610	48545610	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccacgtcgtccagggcccCgggctgcagggagctcaacg	6	5	14	16	4	1	0	1	0	0	0	4	1	3	1	4	3	3	3	4	3	1	0	rs147638039	byFrequency	TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr17:48545610C>G	uc010dbr.2	-	1	618	c.565G>C	c.(565-567)GGG>CGG	p.G189R	ACSF2_uc002iqu.2_Intron|ACSF2_uc010wml.1_Intron|ACSF2_uc010wmm.1_Intron|ACSF2_uc010wmn.1_Intron|ACSF2_uc010wmo.1_Intron|CHAD_uc010dbs.2_Missense_Mutation_p.G189R|ACSF2_uc010dbt.1_5'Flank	NM_001267	NP_001258	O15335	CHAD_HUMAN	chondroadherin precursor	189	LRR 5.				regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(2)|central_nervous_system(1)	3	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			TCCAGGGCCCCGGGCTGCAGG	0.637													3	113					0	0	0	0	G	48545610	G	G	48545610	3	3	44	1	0	0	0	0	1	0	0	0	3325	652	23	3	526	3	CHAD	17	48545610	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08	1698162	48545610	32649600	39	9216											
AXIN2	8313	broad.mit.edu	37	chr17	63554319	63554319	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggagacaatgctgttgttCtcaatgtaccttttgtagat	9	17	9	6	0	1	2	1	0	1	2	2	3	1	2	1	1	2	5	1	1	4	7			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr17:63554319C>T	uc002jfi.2	-	2	709	c.420G>A	c.(418-420)GAG>GAA	p.E140E	AXIN2_uc010den.1_Silent_p.E140E|AXIN2_uc002jfh.2_Silent_p.E140E|AXIN2_uc002jfj.1_Silent_p.E140E	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	140	RGS.				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						TGCTGTTGTTCTCAATGTACC	0.453									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				6	176					0	0	0	0	T	63554319	T	T	63554319	2	4	44	1	0	0	0	0	0	0	0	1	1239	912	32	2		2	AXIN2	17	63554319	Silent	SNP	C	TCGA-CN-4733-01A-02D-1870-08	15008709	63554319	17640891	40	9217											
ACTL9	284382	broad.mit.edu	37	chr19	8808007	8808007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggaagcgaccctcgaagcCggtgaagagcgaggacccac	11	2	14	14	5	0	2	0	1	0	1	1	7	0	4	4	3	3	0	4	3	3	0			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr19:8808007C>T	uc002mkl.2	-	1	1166	c.1045G>A	c.(1045-1047)GGC>AGC	p.G349S		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	349						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						CCCTCGAAGCCGGTGAAGAGC	0.637													4	38					0	0	0	0	T	8808007	T	T	8808007	3	4	44	1	0	0	0	0	1	0	0	0	203	652	23	1	209	1	ACTL9	19	8808007	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08		8808007	50320976	41	9218											
DPF1	8193	broad.mit.edu	37	chr19	38704349	38704349	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcactgccagcggtaggtccGcacggctgccgtcatgttca	6	8	13	14	4	2	0	2	0	0	0	3	0	3	0	3	3	3	5	3	3	1	2			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr19:38704349G>A	uc002ohl.2	-	9	922	c.895C>T	c.(895-897)CGG>TGG	p.R299W	DPF1_uc002ohm.2_Missense_Mutation_p.R343W|DPF1_uc002ohn.2_Missense_Mutation_p.R261W|DPF1_uc010xtu.1_Missense_Mutation_p.R317W|DPF1_uc010xtv.1_Missense_Mutation_p.R317W	NM_004647	NP_004638	Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1 isoform	299	PHD-type 1.				induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding				0	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CGGTAGGTCCGCACGGCTGCC	0.667													4	65					0	0	0	0	A	38704349	A	A	38704349	3	1	44	1	0	0	0	0	1	0	0	0	4738	1086	38	1	259	1	DPF1	19	38704349	Missense_Mutation	SNP	G	TCGA-CN-4733-01A-02D-1870-08	29896342	38704349	20424634	42	9219											
CSRP2BP	57325	broad.mit.edu	37	chr20	18123449	18123449	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgaggatcaggcatcagtgGacttatcgcacgaccagagt	11	7	12	11	3	2	1	2	0	0	1	3	5	2	3	2	3	0	2	2	3	1	1	rs34336937		TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr20:18123449G>A	uc002wqj.2	+	2	767	c.145G>A	c.(145-147)GAC>AAC	p.D49N	CSRP2BP_uc002wqk.2_5'Flank	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	49					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						GGCATCAGTGGACTTATCGCA	0.537													4	83					0	0	0	0	A	18123449	A	A	18123449	3	1	44	1	0	0	0	0	1	0	0	0	3985	1174	41	2	147	2	CSRP2BP	20	18123449	Missense_Mutation	SNP	G	TCGA-CN-4733-01A-02D-1870-08		18123449	44902071	43	9220											
DGCR2	9993	broad.mit.edu	37	chr22	19028791	19028791	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagccagggatcctgcggccGaggttgaagtggtgcactgg	8	7	17	9	2	0	1	0	1	0	0	1	3	1	2	3	5	3	2	3	5	2	1			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr22:19028791G>A	uc002zoq.1	-	9	1424	c.1176C>T	c.(1174-1176)CTC>CTT	p.L392L	DGCR2_uc002zor.1_Silent_p.L168L|DGCR2_uc011agr.1_Silent_p.L348L	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	392	Cytoplasmic (Potential).				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					TCCTGCGGCCGAGGTTGAAGT	0.627													5	47					0	0	0	0	A	19028791	A	A	19028791	2	1	44	1	0	0	0	0	0	0	0	1	4483	1045	37	1		1	DGCR2	22	19028791	Silent	SNP	G	TCGA-CN-4733-01A-02D-1870-08		19028791	32275775	44	9221											
EIF3D	8664	broad.mit.edu	37	chr22	36916654	36916654	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctgatacttccaagtagcGcatcttcatcaactgaggaa	12	11	7	11	1	4	2	2	2	2	0	5	3	5	3	1	1	3	2	1	1	5	4			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr22:36916654G>A	uc003apq.2	-	7	663	c.547C>T	c.(547-549)CGC>TGC	p.R183C	EIF3D_uc011amr.1_Missense_Mutation_p.R10C|EIF3D_uc003apr.2_Missense_Mutation_p.R183C|EIF3D_uc011ams.1_Missense_Mutation_p.R86C|EIF3D_uc011amt.1_Missense_Mutation_p.R134C	NM_003753	NP_003744	O15371	EIF3D_HUMAN	eukaryotic translation initiation factor 3	183						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			pancreas(1)	1						TCCAAGTAGCGCATCTTCATC	0.428													3	46					0	0	0	0	A	36916654	A	A	36916654	3	1	44	1	0	0	0	0	1	0	0	0	5038	1087	38	1	1135	1	EIF3D	22	36916654	Missense_Mutation	SNP	G	TCGA-CN-4733-01A-02D-1870-08	17887863	36916654	14387912	45	9222											
CARD10	29775	broad.mit.edu	37	chr22	37891803	37891803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtgccccggtccaggtccCgcagagtgagggggtcaacc	6	5	16	14	3	1	2	1	1	0	1	3	2	3	2	5	5	2	1	5	5	1	0			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr22:37891803C>T	uc003asx.1	-	14	2270	c.2267G>A	c.(2266-2268)CGG>CAG	p.R756Q	CARD10_uc003ast.1_RNA|CARD10_uc003asv.1_5'Flank|CARD10_uc011ank.1_Missense_Mutation_p.R74Q|CARD10_uc003asw.1_Missense_Mutation_p.R470Q|CARD10_uc003asy.1_Missense_Mutation_p.R756Q	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	756					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					GTCCAGGTCCCGCAGAGTGAG	0.642													6	32					0	0	0	0	T	37891803	T	T	37891803	3	4	44	1	0	0	0	0	1	0	0	0	2656	652	23	1	859	1	CARD10	22	37891803	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08	975149	37891803	13412763	46	9223											
BEND2	139105	broad.mit.edu	37	chrX	18195820	18195820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggctgcttgcttaggtttgGccatattttgtacggccagc	6	14	12	9	1	0	0	0	0	0	0	0	0	0	0	2	4	4	5	2	4	3	7			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chrX:18195820G>A	uc004cyj.3	-	10	1653	c.1499C>T	c.(1498-1500)GCC>GTC	p.A500V	BEND2_uc010nfb.2_Missense_Mutation_p.A409V	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	500	BEN 1.									ovary(3)|kidney(1)|central_nervous_system(1)	5						CTTAGGTTTGGCCATATTTTG	0.393													4	183					0	0	0	0	A	18195820	A	A	18195820	3	1	44	1	0	0	0	0	1	0	0	0	1400	1203	42	4	946	4	BEND2	23	18195820	Missense_Mutation	SNP	G	TCGA-CN-4733-01A-02D-1870-08		18195820	137074740	47	9224											
RBM10	8241	broad.mit.edu	37	chrX	47045133	47045133	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaaaccttgagattcacCggcgagcccacttgtcagaa	13	7	9	12	2	2	2	2	1	0	2	2	4	2	2	3	1	3	1	3	1	3	3			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chrX:47045133C>T	uc004dhf.2	+	21	2753	c.2374C>T	c.(2374-2376)CGG>TGG	p.R792W	RBM10_uc004dhg.2_Missense_Mutation_p.R714W|RBM10_uc004dhh.2_Missense_Mutation_p.R791W|RBM10_uc010nhq.2_Missense_Mutation_p.R715W|RBM10_uc004dhi.2_Missense_Mutation_p.R857W	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	792					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						TGAGATTCACCGGCGAGCCCA	0.572													6	22					0	0	0	0	T	47045133	T	T	47045133	3	4	44	1	0	0	0	0	1	0	0	0	13176	643	23	1	2452	1	RBM10	23	47045133	Missense_Mutation	SNP	C	TCGA-CN-4733-01A-02D-1870-08	28849313	47045133	108225427	48	9225											
LRRC47	57470	broad.mit.edu	37	chr1	3703592	3703592	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccggccggcatctcccacgtCctgctcctccccatcaccac	5	7	6	23	3	2	0	1	0	1	0	6	0	5	0	8	2	1	2	8	2	0	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:3703592C>G	uc001akx.1	-	2	926	c.898G>C	c.(898-900)GAC>CAC	p.D300H		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	300					translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		tctcccacgtcctgctcctcc	0.393													17	14					0	0	0	0	G	3703592	G	G	3703592	3	3	45	1	0	0	0	0	1	0	0	0	9054	855	30	2	877	2	LRRC47	1	3703592	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08		3703592	245547029	1	9226											
FBXO6	26270	broad.mit.edu	37	chr1	11728956	11728956	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actggaaaatcttctacttcCtacggagcctgcataggaac	12	10	8	11	1	2	0	0	0	2	0	3	3	3	3	2	3	5	1	2	3	6	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:11728956C>T	uc001aso.2	+	2	407	c.241C>T	c.(241-243)CTA>TTA	p.L81L		NM_018438	NP_060908	Q9NRD1	FBX6_HUMAN	F-box only protein 6	81	FBA.				DNA damage checkpoint|DNA repair|ER-associated protein catabolic process|response to unfolded protein|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	glycoprotein binding			lung(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.25e-06)|COAD - Colon adenocarcinoma(227;0.000251)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		CTTCTACTTCCTACGGAGCCT	0.522													6	91					0	0	0	0	T	11728956	T	T	11728956	2	4	45	1	0	0	0	0	0	0	0	1	5791	680	24	4		4	FBXO6	1	11728956	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	8025364	11728956	237521665	2	9227											
TNFRSF1B	7133	broad.mit.edu	37	chr1	12251958	12251958	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgctgcgcaagtgccgcccGggcttcggcgtggccagacc	4	5	15	17	6	0	1	0	0	0	1	1	1	0	1	5	3	2	3	5	3	1	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:12251958G>A	uc001att.2	+	4	524	c.435G>A	c.(433-435)CCG>CCA	p.P145P	TNFRSF1B_uc001atu.2_5'UTR|TNFRSF1B_uc009vnk.2_RNA	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	145	TNFR-Cys 3.|Extracellular (Potential).				apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			liver(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	AGTGCCGCCCGGGCTTCGGCG	0.687													30	19					0	0	0	0	A	12251958	A	A	12251958	2	1	45	1	0	0	0	0	0	0	0	1	16360	1103	39	1		1	TNFRSF1B	1	12251958	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	523002	12251958	236998663	3	9228											
EPHA2	1969	broad.mit.edu	37	chr1	16464404	16464404	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcggctggttaccaggcctGagacgccattgcgggcctcc	5	8	14	14	3	0	1	0	1	0	1	1	2	1	1	5	4	3	2	5	4	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:16464404G>C	uc001aya.1	-	5	1393	c.1256C>G	c.(1255-1257)TCA>TGA	p.S419*	EPHA2_uc010oca.1_Nonsense_Mutation_p.S419*	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	419	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	TACCAGGCCTGAGACGCCATT	0.637													38	36					0	0	0	0	C	16464404	C	C	16464404	4	2	45	1	0	0	0	0	0	1	0	0	5191	1294	45	2	1726	2	EPHA2	1	16464404	Nonsense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	4212446	16464404	232786217	4	9229											
CLSPN	63967	broad.mit.edu	37	chr1	36228069	36228069	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatggaccccactctccaaaGatggttcttttttctaaaag	12	13	6	10	0	3	1	0	0	3	1	4	2	3	2	3	2	0	1	3	2	4	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:36228069G>A	uc001bzi.2	-	5	838	c.758C>T	c.(757-759)TCT>TTT	p.S253F	CLSPN_uc009vux.2_Missense_Mutation_p.S253F	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	253					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACTCTCCAAAGATGGTTCTTT	0.398													58	59					0	0	0	0	A	36228069	A	A	36228069	3	1	45	1	0	0	0	0	1	0	0	0	3575	942	33	2	3345	2	CLSPN	1	36228069	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	19763665	36228069	213022552	5	9230											
FAM151A	338094	broad.mit.edu	37	chr1	55089015	55089015	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacagacacacaggtaatGccggcaaacacccacttgac	15	4	7	15	1	0	2	0	1	0	1	0	2	0	2	3	2	2	2	3	2	2	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:55089015G>T	uc001cxn.2	-	1	186	c.54C>A	c.(52-54)GGC>GGA	p.G18G	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	18	Helical; (Potential).					integral to membrane					0						CACAGGTAATGCCGGCAAACA	0.597													114	98					4.64626e-59	5.23588e-59	1	0	T	55089015	T	T	55089015	2	4	45	1	0	0	0	0	0	0	0	1	5486	1306	46	4		4	FAM151A	1	55089015	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	18860946	55089015	194161606	6	9231											
ADAR	103	broad.mit.edu	37	chr1	154574600	154574600	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccagggagtataaaactcgaTtgatttctttcttcggagtc	10	14	9	8	2	2	1	0	1	2	0	5	4	2	3	1	2	1	1	1	2	3	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:154574600T>C	uc001ffh.2	-	2	718	c.518A>G	c.(517-519)AAT>AGT	p.N173S	ADAR_uc001ffj.2_Missense_Mutation_p.N173S|ADAR_uc001ffi.2_Missense_Mutation_p.N173S|ADAR_uc001ffk.2_5'UTR|ADAR_uc001ffl.1_5'UTR	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	173	|DRADA 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TAAAACTCGATTGATTTCTTT	0.498													81	275					0	0	0	0	C	154574600	C	C	154574600	3	2	45	1	0	0	0	0	1	0	0	0	281	1493	52	5	3218	5	ADAR	1	154574600	Missense_Mutation	SNP	T	TCGA-CN-4734-01A-01D-1434-08	99485585	154574600	94676021	7	9232											
PMVK	10654	broad.mit.edu	37	chr1	154898894	154898894	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctacaacgcggaccgtctgCgtcacggccccataggcctc	7	6	11	17	5	2	0	1	0	1	0	3	1	2	1	4	3	3	1	4	3	3	2	rs137902262	byFrequency	TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:154898894C>T	uc001ffq.2	-	4	701	c.378G>A	c.(376-378)ACG>ACA	p.T126T		NM_006556	NP_006547	Q15126	PMVK_HUMAN	phosphomevalonate kinase	126					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding				0	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGACCGTCTGCGTCACGGCCC	0.617													19	48					0	0	0	0	T	154898894	T	T	154898894	2	4	45	1	0	0	0	0	0	0	0	1	12199	755	27	1		1	PMVK	1	154898894	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	324294	154898894	94351727	8	9233											
EFNA3	1944	broad.mit.edu	37	chr1	155057801	155057801	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccccgcacagccccatcaaGttctcggagaagttccagcg	9	6	10	16	3	2	1	1	0	1	1	4	2	3	1	5	1	2	3	5	1	2	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:155057801G>A	uc001fhf.2	+	2	433	c.363G>A	c.(361-363)AAG>AAA	p.K121K	EFNA3_uc010pew.1_Silent_p.K116K|EFNA3_uc010pex.1_Silent_p.K121K|EFNA3_uc001fhg.2_Silent_p.K98K	NM_004952	NP_004943	P52797	EFNA3_HUMAN	ephrin A3 precursor	121					cell-cell signaling	anchored to membrane|integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity				0	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		all cancers(21;5.67e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000284)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCCCCATCAAGTTCTCGGAGA	0.647													5	21					0	0	0	0	A	155057801	A	A	155057801	2	1	45	1	0	0	0	0	0	0	0	1	4974	1020	36	4		4	EFNA3	1	155057801	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	158907	155057801	94192820	9	9234											
SPTA1	6708	broad.mit.edu	37	chr1	158650472	158650472	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatttcttatgcagaacttcGgtgcgctcccagtcttcacc	8	13	7	13	2	3	1	1	0	2	1	5	1	4	1	2	1	3	2	2	1	3	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:158650472G>A	uc001fst.1	-	5	778	c.579C>T	c.(577-579)ACC>ACT	p.T193T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	193	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GCAGAACTTCGGTGCGCTCCC	0.463													36	125					0	0	0	0	A	158650472	A	A	158650472	2	1	45	1	0	0	0	0	0	0	0	1	15182	1103	39	1		1	SPTA1	1	158650472	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	3592671	158650472	90600149	10	9235											
FCRLB	127943	broad.mit.edu	37	chr1	161693366	161693366	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgtatcgatgccagacaCggggagcacccgtcagtgac	9	6	15	11	3	1	2	1	1	0	1	2	4	1	3	2	3	2	2	2	3	1	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:161693366C>T	uc001gbh.2	+	5	496	c.262C>T	c.(262-264)CGG>TGG	p.R88W	FCRLB_uc009wus.2_Missense_Mutation_p.R88W|FCRLB_uc001gbj.2_Missense_Mutation_p.R88W|FCRLB_uc001gbk.2_Missense_Mutation_p.R88W|FCRLB_uc001gbl.2_Missense_Mutation_p.R81W|FCRLB_uc001gbm.2_Missense_Mutation_p.R81W|FCRLB_uc001gbi.2_Missense_Mutation_p.R88W|FCRLB_uc001gbn.3_5'Flank	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	88	Ig-like C2-type 1.					endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			ATGCCAGACACGGGGAGCACC	0.577													30	65					0	0	0	0	T	161693366	T	T	161693366	3	4	45	1	0	0	0	0	1	0	0	0	5833	527	19	1	272	1	FCRLB	1	161693366	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	3042894	161693366	87557255	11	9236											
DNM3	26052	broad.mit.edu	37	chr1	172348185	172348185	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgatgagaatggacaagcaGaaaacttttccatggaccca	16	8	9	8	0	0	3	0	2	0	2	1	6	1	5	2	2	2	1	2	2	4	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:172348185G>C	uc001gie.2	+	18	2097	c.1921G>C	c.(1921-1923)GAA>CAA	p.E641Q	DNM3_uc001gif.2_Missense_Mutation_p.E637Q|DNM3_uc001gih.1_5'UTR	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	647					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						TGGACAAGCAGAAAACTTTTC	0.388													13	36					0	0	0	0	C	172348185	C	C	172348185	3	2	45	1	0	0	0	0	1	0	0	0	4695	943	33	2	1991	2	DNM3	1	172348185	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	10654819	172348185	76902436	12	9237											
ZBTB37	84614	broad.mit.edu	37	chr1	173842693	173842693	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaatggatgagcctaagcaaCccagctcccaggtatggagt	12	7	12	10	0	0	1	0	1	0	0	1	4	1	3	3	3	4	3	3	3	4	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:173842693C>A	uc009wwp.1	+	4	1288	c.1012C>A	c.(1012-1014)CCC>ACC	p.P338T	ZBTB37_uc001gjp.1_Intron|ZBTB37_uc001gjq.3_Missense_Mutation_p.P338T|ZBTB37_uc001gjr.2_Missense_Mutation_p.P338T	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCCTAAGCAACCCAGCTCCCA	0.458													14	66					6.72482e-11	7.07541e-11	1	0	A	173842693	A	A	173842693	3	1	45	1	0	0	0	0	1	0	0	0	17605	507	18	4	1018	4	ZBTB37	1	173842693	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	1494508	173842693	75407928	13	9238											
NR5A2	2494	broad.mit.edu	37	chr1	200014674	200014674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaagcgttgtccttactgtcGttttcaaaaatgtctaagtg	11	15	8	7	2	2	0	1	0	1	0	4	0	3	0	1	0	2	2	1	0	5	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:200014674G>A	uc001gvb.2	+	4	631	c.425G>A	c.(424-426)CGT>CAT	p.R142H	NR5A2_uc001gvc.2_Missense_Mutation_p.R96H|NR5A2_uc009wzh.2_Missense_Mutation_p.R102H|NR5A2_uc010pph.1_Missense_Mutation_p.R70H	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	142	Nuclear receptor.|NR C4-type.				embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					CCTTACTGTCGTTTTCAAAAA	0.343													22	73					0	0	0	0	A	200014674	A	A	200014674	3	1	45	1	0	0	0	0	1	0	0	0	10690	1145	40	1	439	1	NR5A2	1	200014674	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	26171981	200014674	49235947	14	9239											
CACNA1S	779	broad.mit.edu	37	chr1	201079386	201079386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatggtgagcaagatgatcGtctcgaagggcctggagcca	11	7	15	8	2	1	4	0	2	1	2	3	6	1	5	2	3	2	1	2	3	2	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:201079386G>A	uc001gvv.2	-	2	391	c.164C>T	c.(163-165)ACG>ATG	p.T55M		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	55	I.|Helical; Name=S1 of repeat I; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CAAGATGATCGTCTCGAAGGG	0.572													24	53					0	0	0	0	A	201079386	A	A	201079386	3	1	45	1	0	0	0	0	1	0	0	0	2559	1145	40	1	5629	1	CACNA1S	1	201079386	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	1064712	201079386	48171235	15	9240											
ZC3H11A	9877	broad.mit.edu	37	chr1	203821361	203821361	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatgagcatgaaaactcgccGactcagctctgcctcaacag	13	7	8	13	2	3	2	2	2	1	0	4	3	3	2	2	0	5	2	2	0	4	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:203821361G>A	uc001hac.2	+	20	2883	c.2267G>A	c.(2266-2268)CGA>CAA	p.R756Q	ZC3H11A_uc001had.2_Missense_Mutation_p.R756Q|ZC3H11A_uc001hae.2_Missense_Mutation_p.R756Q|ZC3H11A_uc001haf.2_Missense_Mutation_p.R756Q|ZC3H11A_uc010pqm.1_Missense_Mutation_p.R702Q	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	756							nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AAAACTCGCCGACTCAGCTCT	0.507													36	83					0	0	0	0	A	203821361	A	A	203821361	3	1	45	1	0	0	0	0	1	0	0	0	17627	1058	37	1	2329	1	ZC3H11A	1	203821361	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	2741975	203821361	45429260	16	9241											
FAM84A	151354	broad.mit.edu	37	chr2	14774194	14774194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgaaaaggacgaactgcggGtcggggttgcctacttcttc	8	11	13	9	3	1	1	0	1	1	0	3	3	1	2	1	4	4	1	1	4	4	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:14774194G>A	uc002rbz.1	+	2	333	c.91G>A	c.(91-93)GTC>ATC	p.V31I	FAM84A_uc002rca.1_5'Flank	NM_145175	NP_660158	Q96KN4	FA84A_HUMAN	family with sequence similarity 84, member A	31										pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(1;0.00969)			CGAACTGCGGGTCGGGGTTGC	0.617													3	56					0	0	0	0	A	14774194	A	A	14774194	3	1	45	1	0	0	0	0	1	0	0	0	5673	1261	44	4	93	4	FAM84A	2	14774194	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08		14774194	228425179	17	9242											
ITSN2	50618	broad.mit.edu	37	chr2	24521584	24521584	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttttagagtttaacctgaCaatttcttcttgttctctat	8	21	4	8	0	3	2	0	1	3	1	4	2	3	2	1	0	1	2	1	0	4	10			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:24521584C>A	uc002rfe.2	-	13	1702	c.1444G>T	c.(1444-1446)GTC>TTC	p.V482F	ITSN2_uc002rff.2_Missense_Mutation_p.V482F|ITSN2_uc002rfg.2_Missense_Mutation_p.V482F|ITSN2_uc010eyd.2_Missense_Mutation_p.V507F	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	482	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTAACCTGACAATTTCTTCT	0.398													36	135					4.11147e-13	4.43081e-13	1	0	A	24521584	A	A	24521584	3	1	45	1	0	0	0	0	1	0	0	0	7966	478	17	4	3812	4	ITSN2	2	24521584	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	9747390	24521584	218677789	18	9243											
DNMT3A	1788	broad.mit.edu	37	chr2	25467435	25467435	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttgttgtttccgcacatGagcacctcacggcccccaca	8	9	8	16	2	1	1	1	1	0	0	2	1	2	1	4	1	1	5	4	1	0	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:25467435G>A	uc002rgc.2	-	14	1898	c.1641C>T	c.(1639-1641)CTC>CTT	p.L547L	DNMT3A_uc002rgd.2_Silent_p.L547L|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.L358L	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	547	PHD-type; atypical.|Interaction with the PRC2/EED-EZH2 complex (By similarity).|ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCCGCACATGAGCACCTCAC	0.632			Mis|F|N|S		AML								15	49					0	0	0	0	A	25467435	A	A	25467435	2	1	45	1	0	0	0	0	0	0	0	1	4698	1277	45	2		2	DNMT3A	2	25467435	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	945851	25467435	217731938	19	9244											
KRTCAP3	200634	broad.mit.edu	37	chr2	27665758	27665758	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgtccaggaaccttcttcGccctccactggtgagaggga	7	8	13	13	2	1	1	0	1	1	1	4	4	3	3	4	4	1	0	4	4	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:27665758G>T	uc002rks.2	+	3	280	c.263G>T	c.(262-264)CGC>CTC	p.R88L	KRTCAP3_uc010ylr.1_Missense_Mutation_p.R88L|KRTCAP3_uc002rkt.2_Missense_Mutation_p.R70L	NM_173853	NP_776252	Q53RY4	KCP3_HUMAN	keratinocyte associated protein 3	88						integral to membrane					0	Acute lymphoblastic leukemia(172;0.155)					AACCTTCTTCGCCCTCCACTG	0.587													27	54					7.68411e-24	8.48693e-24	1	0	T	27665758	T	T	27665758	3	4	45	1	0	0	0	0	1	0	0	0	8619	1087	38	3	273	3	KRTCAP3	2	27665758	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	2198323	27665758	215533615	20	9245											
MTA3	57504	broad.mit.edu	37	chr2	42909708	42909708	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaaatatggcaaagacttCaatgacatacggcaagattt	18	9	8	6	1	1	3	1	1	0	2	1	4	1	3	0	2	1	2	0	2	7	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:42909708C>A	uc002rso.1	+	10	1372	c.702C>A	c.(700-702)TTC>TTA	p.F234L	MTA3_uc002rsp.1_Missense_Mutation_p.F234L|MTA3_uc002rsq.2_Missense_Mutation_p.F290L|MTA3_uc002rsr.2_Missense_Mutation_p.F290L	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	290	SANT.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						GCAAAGACTTCAATGACATAC	0.363													4	16					0.00024832	0.000254042	1	0	A	42909708	A	A	42909708	3	1	45	1	0	0	0	0	1	0	0	0	9963	825	29	2	904	2	MTA3	2	42909708	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	15243950	42909708	200289665	21	9246											
VRK2	7444	broad.mit.edu	37	chr2	58350334	58350334	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaggccataatgggacaatAgagtttaccagcttggatgc	14	9	11	7	0	0	1	0	0	0	1	0	3	0	3	2	3	3	2	2	3	5	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:58350334A>G	uc002rzo.2	+	11	1387	c.642A>G	c.(640-642)ATA>ATG	p.I214M	VRK2_uc010fcb.2_Missense_Mutation_p.I214M|VRK2_uc002rzs.2_Missense_Mutation_p.I214M|VRK2_uc002rzr.2_Missense_Mutation_p.I214M|VRK2_uc010fcc.2_Missense_Mutation_p.I96M|VRK2_uc002rzv.2_Missense_Mutation_p.I214M|VRK2_uc010fcd.2_Missense_Mutation_p.I191M|VRK2_uc002rzp.2_Missense_Mutation_p.I214M|VRK2_uc010ypg.1_Missense_Mutation_p.I214M|VRK2_uc002rzq.2_Missense_Mutation_p.I214M|VRK2_uc002rzu.2_Missense_Mutation_p.I214M|VRK2_uc002rzt.2_Missense_Mutation_p.I96M|VRK2_uc010yph.1_Missense_Mutation_p.I96M	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	vaccinia related kinase 2 isoform 2	214	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						ATGGGACAATAGAGTTTACCA	0.383													3	203					0	0	0	0	G	58350334	G	G	58350334	3	3	45	1	0	0	0	0	1	0	0	0	17288	410	15	5	668	5	VRK2	2	58350334	Missense_Mutation	SNP	A	TCGA-CN-4734-01A-01D-1434-08	15440626	58350334	184849039	22	9247											
MOGS	7841	broad.mit.edu	37	chr2	74688809	74688809	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggcgggatgaggtggggtCcagcagtcgcagcagcaagg	10	4	19	8	2	0	1	0	1	0	0	2	2	1	2	1	6	3	4	1	6	2	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:74688809C>T	uc010ffj.2	-	4	2270	c.2107G>A	c.(2107-2109)GAC>AAC	p.D703N	MOGS_uc010ffh.2_Missense_Mutation_p.D428N|MOGS_uc010yrt.1_Missense_Mutation_p.D584N|MOGS_uc010ffi.2_Missense_Mutation_p.D597N	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	703	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						GAGGTGGGGTCCAGCAGTCGC	0.607													28	72					0	0	0	0	T	74688809	T	T	74688809	3	4	45	1	0	0	0	0	1	0	0	0	9750	855	30	2	410	2	MOGS	2	74688809	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	16338475	74688809	168510564	23	9248											
SEMA4C	54910	broad.mit.edu	37	chr2	97526459	97526459	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctcaggcagggggtgcccGagccctccccggtcctcccc	4	5	13	19	2	1	0	1	0	0	0	4	1	4	0	7	4	3	2	7	4	0	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:97526459G>A	uc002sxh.3	-	15	2566	c.2406C>T	c.(2404-2406)CTC>CTT	p.L802L	ANKRD39_uc002sxd.3_5'Flank|SEMA4C_uc002sxf.3_Silent_p.L302L|SEMA4C_uc002sxe.2_Silent_p.L343L|SEMA4C_uc002sxg.3_Silent_p.L855L	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	802	Cytoplasmic (Potential).				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						GGGGGTGCCCGAGCCCTCCCC	0.627													51	142					0	0	0	0	A	97526459	A	A	97526459	2	1	45	1	0	0	0	0	0	0	0	1	14098	1045	37	1		1	SEMA4C	2	97526459	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	22837650	97526459	145672914	24	9249											
RBM43	375287	broad.mit.edu	37	chr2	152107860	152107860	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctccacttctagcagtctCaggtactaaggtcctgactg	8	13	8	12	0	3	1	1	1	3	0	6	1	4	1	2	2	2	2	2	2	3	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:152107860C>T	uc002txh.2	-	4	782	c.634G>A	c.(634-636)GAG>AAG	p.E212K		NM_198557	NP_940959	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	212							nucleotide binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		CTAGCAGTCTCAGGTACTAAG	0.393													48	127					0	0	0	0	T	152107860	T	T	152107860	3	4	45	1	0	0	0	0	1	0	0	0	13202	835	29	2	443	2	RBM43	2	152107860	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	54581401	152107860	91091513	25	9250											
TTN	7273	broad.mit.edu	37	chr2	179427722	179427722	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgtcagtgagaatgccttCtgccttttcccatttaactt	7	16	6	12	0	2	1	1	1	1	1	3	2	3	1	4	0	3	0	4	0	2	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:179427722C>T	uc010zfg.1	-	275	75657	c.75433G>A	c.(75433-75435)GAA>AAA	p.E25145K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E18840K|TTN_uc010zfi.1_Missense_Mutation_p.E18773K|TTN_uc010zfj.1_Missense_Mutation_p.E18648K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26072							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAATGCCTTCTGCCTTTTCC	0.438													30	131					0	0	0	0	T	179427722	T	T	179427722	3	4	45	1	0	0	0	0	1	0	0	0	16803	922	32	2	24990	2	TTN	2	179427722	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	27319862	179427722	63771651	26	9251											
PDE1A	5136	broad.mit.edu	37	chr2	183129053	183129053	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttcatcgatataaactgcttCcagcacagatgccgcatatt	12	12	6	11	2	1	1	1	0	0	1	3	2	2	1	2	0	4	3	2	0	4	6	rs149743969		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:183129053C>G	uc002uos.2	-	3	274	c.190G>C	c.(190-192)GAA>CAA	p.E64Q	PDE1A_uc010zfp.1_5'UTR|PDE1A_uc002uoq.1_Missense_Mutation_p.E64Q|PDE1A_uc010zfq.1_Missense_Mutation_p.E64Q|PDE1A_uc002uor.2_Missense_Mutation_p.E48Q|PDE1A_uc002uov.1_RNA	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	64					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TAAACTGCTTCCAGCACAGAT	0.378													23	100					0	0	0	0	G	183129053	G	G	183129053	3	3	45	1	0	0	0	0	1	0	0	0	11687	864	30	2	1547	2	PDE1A	2	183129053	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	3701331	183129053	60070320	27	9252											
CASP8	841	broad.mit.edu	37	chr2	202151270	202151270	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatggggaaacagatgcctCagcctactttcacactaaga	14	8	8	11	0	2	2	2	0	0	2	2	3	2	3	2	2	4	0	2	2	3	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:202151270C>T	uc002uxr.1	+	10	1602	c.1393C>T	c.(1393-1395)CAG>TAG	p.Q465*	CASP8_uc002uxp.1_Nonsense_Mutation_p.Q482*|CASP8_uc002uxq.1_Nonsense_Mutation_p.Q450*|CASP8_uc002uxt.1_Nonsense_Mutation_p.Q524*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.Q450*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.Q381*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	465					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						ACAGATGCCTCAGCCTACTTT	0.313										HNSCC(4;0.00038)			36	40					0	0	0	0	T	202151270	T	T	202151270	4	4	45	1	0	0	0	0	0	1	0	0	2689	827	29	2	1704	2	CASP8	2	202151270	Nonsense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	19022217	202151270	41048103	28	9253											
ERBB4	2066	broad.mit.edu	37	chr2	212488710	212488710	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcttcagctcagtttctttCaaaatacgaagttgagcttg	10	15	7	9	1	5	1	3	1	2	0	5	2	5	1	0	0	3	4	0	0	4	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:212488710C>G	uc002veg.1	-	18	2237	c.2139G>C	c.(2137-2139)TTG>TTC	p.L713F	ERBB4_uc002veh.1_Missense_Mutation_p.L713F|ERBB4_uc010zji.1_Missense_Mutation_p.L703F|ERBB4_uc010zjj.1_Missense_Mutation_p.L703F|ERBB4_uc010fut.1_Missense_Mutation_p.L713F	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	713	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CAGTTTCTTTCAAAATACGAA	0.403										TSP Lung(8;0.080)			24	71					0	0	0	0	G	212488710	G	G	212488710	3	3	45	1	0	0	0	0	1	0	0	0	5233	825	29	2	1831	2	ERBB4	2	212488710	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	10337440	212488710	30710663	29	9254											
ABCB6	10058	broad.mit.edu	37	chr2	220081144	220081144	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagacgtaactggtaacagtCcaggccagagagttccaagg	14	6	12	9	1	0	2	0	0	0	2	2	3	2	2	3	3	2	3	3	3	4	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:220081144C>T	uc002vkc.1	-	4	1189	c.912G>A	c.(910-912)TGG>TGA	p.W304*	ABCB6_uc010fwe.1_Nonsense_Mutation_p.W258*|ABCB6_uc010zku.1_RNA	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	304	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGTAACAGTCCAGGCCAGAG	0.552													18	95					0	0	0	0	T	220081144	T	T	220081144	4	4	45	1	0	0	0	0	0	1	0	0	45	856	30	2	1680	2	ABCB6	2	220081144	Nonsense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	7592434	220081144	23118229	30	9255											
SPEG	10290	broad.mit.edu	37	chr2	220300061	220300061	+	Frame_Shift_Del	DEL	C	-	-																															gggccgggcctcctgcgaggCggtgctcacagtgctggagg																										TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:220300061delC	uc010fwg.2	+	1	362	c.362delC	c.(361-363)GCGfs	p.A121fs	SPEG_uc002vlm.2_5'Flank	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	121	Ig-like 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCCTGCGAGGCGGTGCTCACA	0.741													---	---	---								-	220300061	-	-	220300061	7	5	45	1	0	1	0	1	0	0	0	0	15102	768	27	0	364	0	SPEG	2	220300061	Frame_Shift_Del	DEL	C	TCGA-CN-4734-01A-01D-1434-08	218917	220300061	22899312	31	9256											
TADA3	10474	broad.mit.edu	37	chr3	9828794	9828794	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcagcagggcatccacatCtaagcgggcacaggaaagga	13	5	12	11	1	2	0	1	0	1	0	3	2	3	2	1	4	2	3	1	4	2	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:9828794C>T	uc003bsx.1	-	6	1255	c.707_splice	c.e6-1	p.D236_splice	TADA3_uc010hcn.1_Splice_Site_p.D236_splice|TADA3_uc003bsy.2_Splice_Site_p.D236_splice|TADA3_uc003bsw.1_Splice_Site_p.D65_splice	NM_006354	NP_006345	O75528	TADA3_HUMAN	transcriptional adaptor 3 isoform a						estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity				0						GCATCCACATCTAAGCGGGCA	0.597											OREG0015382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	212					0	0	0	0	T	9828794	T	T	9828794	5	4	45	1	0	0	0	0	0	0	1	0	15578	927	32	2	612	2	TADA3	3	9828794	Splice_Site	SNP	C	TCGA-CN-4734-01A-01D-1434-08		9828794	188193636	32	9257											
SATB1	6304	broad.mit.edu	37	chr3	18393545	18393545	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcgccatggtgatgcaccGcgttgctctcctgttcataa	6	13	10	12	3	2	1	1	1	1	0	4	1	2	1	3	1	2	4	3	1	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:18393545G>A	uc003cbh.2	-	10	3453	c.1718C>T	c.(1717-1719)GCG>GTG	p.A573V	SATB1_uc003cbi.2_Missense_Mutation_p.A573V|SATB1_uc003cbj.2_Missense_Mutation_p.A573V	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	573					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						GTGATGCACCGCGTTGCTCTC	0.498													37	112					0	0	0	0	A	18393545	A	A	18393545	3	1	45	1	0	0	0	0	1	0	0	0	13918	1087	38	1	581	1	SATB1	3	18393545	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	8564751	18393545	179628885	33	9258											
PFKFB4	5210	broad.mit.edu	37	chr3	48575989	48575993	+	Frame_Shift_Del	DEL	TGAAG	-	-																															atagcactcaatgcgcctcaTgaagtcctccgtagcctcat																										TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:48575989_48575993delTGAAG	uc003ctv.2	-	7	587_591	c.570_574delCTTCA	c.(568-576)GACTTCATGfs	p.D190fs	PFKFB4_uc003ctw.2_Translation_Start_Site|PFKFB4_uc010hkc.2_Frame_Shift_Del_p.D190fs|PFKFB4_uc003ctx.2_Frame_Shift_Del_p.D147fs|PFKFB4_uc010hkb.2_Frame_Shift_Del_p.D190fs|PFKFB4_uc011bbm.1_Frame_Shift_Del_p.D179fs|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	190_192	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		ATGCGCCTCATGAAGTCCTCCGTAG	0.576													---	---	---								-	48575993	-	-	48575989	7	5	45	1	0	1	0	1	0	0	0	0	11818	1464	51	0	867	0	PFKFB4	3	48575989	Frame_Shift_Del	DEL	TGAAG	TCGA-CN-4734-01A-01D-1434-08	30182444	48575989	149446441	34	9259											
CACNA1D	776	broad.mit.edu	37	chr3	53844075	53844075	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtcactcgacccggtcgtGggccacccctccagcaaccc	7	5	10	19	3	1	0	1	0	0	0	4	2	2	0	6	2	2	1	6	2	1	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:53844075G>A	uc003dgv.3	+	47	6105	c.5942G>A	c.(5941-5943)TGG>TAG	p.W1981*	CACNA1D_uc003dgu.3_Nonsense_Mutation_p.W2001*|CACNA1D_uc003dgy.3_Nonsense_Mutation_p.W1957*|CACNA1D_uc003dgw.3_Nonsense_Mutation_p.W1648*|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1981	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ACCCGGTCGTGGGCCACCCCT	0.612													24	77					0	0	0	0	A	53844075	A	A	53844075	4	1	45	1	0	0	0	0	0	1	0	0	2553	1357	47	4	6300	4	CACNA1D	3	53844075	Nonsense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	5268086	53844075	144178355	35	9260											
PDZRN3	23024	broad.mit.edu	37	chr3	73433477	73433477	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtccttgtcggatttctccGggagctcggtgatatctgag	5	14	13	9	3	2	2	0	2	2	0	6	4	3	4	2	3	1	1	2	3	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:73433477G>A	uc003dpl.1	-	10	2336	c.2240C>T	c.(2239-2241)CCG>CTG	p.P747L	PDZRN3_uc011bgh.1_Missense_Mutation_p.P404L|PDZRN3_uc010hoe.1_Missense_Mutation_p.P445L|PDZRN3_uc011bgf.1_Missense_Mutation_p.P464L|PDZRN3_uc011bgg.1_Missense_Mutation_p.P467L	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	747							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GGATTTCTCCGGGAGCTCGGT	0.612													11	46					0	0	0	0	A	73433477	A	A	73433477	3	1	45	1	0	0	0	0	1	0	0	0	11763	1116	39	1	964	1	PDZRN3	3	73433477	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	19589402	73433477	124588953	36	9261											
PHLDB2	90102	broad.mit.edu	37	chr3	111688638	111688638	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attgacacctgttaccatgtAtcaatcacagagaagacctg	14	10	7	10	0	2	3	2	1	0	2	2	4	2	3	3	0	1	2	3	0	4	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:111688638A>G	uc010hqa.2	+	16	3828	c.3417A>G	c.(3415-3417)GTA>GTG	p.V1139V	PHLDB2_uc003dyc.2_Silent_p.V1123V|PHLDB2_uc003dyd.2_Silent_p.V1096V|PHLDB2_uc003dyg.2_Silent_p.V1139V|PHLDB2_uc003dyh.2_Silent_p.V1096V|PHLDB2_uc003dyi.2_Silent_p.V630V|PHLDB2_uc003dyj.2_Silent_p.V194V	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1139						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GTTACCATGTATCAATCACAG	0.458													27	87					0	0	0	0	G	111688638	G	G	111688638	2	3	45	1	0	0	0	0	0	0	0	1	11907	436	16	5		5	PHLDB2	3	111688638	Silent	SNP	A	TCGA-CN-4734-01A-01D-1434-08	38255161	111688638	86333792	37	9262											
TPRA1	131601	broad.mit.edu	37	chr3	127298632	127298632	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggtgatgcggatcttcGcccgagcagatggaagcttc	8	9	15	9	3	1	2	0	1	1	1	3	6	1	5	1	4	3	2	1	4	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:127298632G>A	uc003ejl.2	-	2	500	c.209C>T	c.(208-210)GCG>GTG	p.A70V	TPRA1_uc003ejm.2_RNA|TPRA1_uc003ejo.2_Missense_Mutation_p.A70V|TPRA1_uc010hsk.2_Missense_Mutation_p.A70V|TPRA1_uc003ejn.2_Missense_Mutation_p.A70V	NM_016372	NP_057456	Q86W33	TPRA1_HUMAN	G protein-coupled receptor 175 isoform 1	70					aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity				0						GCGGATCTTCGCCCGAGCAGA	0.448													10	34					0	0	0	0	A	127298632	A	A	127298632	3	1	45	1	0	0	0	0	1	0	0	0	16484	1087	38	1	948	1	TPRA1	3	127298632	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	15609994	127298632	70723798	38	9263											
ZBBX	79740	broad.mit.edu	37	chr3	167068267	167068267	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgaactttagcaaagcAtcctgaacaataatcttctc	13	12	6	10	0	2	2	0	2	2	0	4	2	3	2	1	1	4	2	1	1	6	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:167068267A>T	uc003fep.2	-	9	792	c.469T>A	c.(469-471)TGC>AGC	p.C157S	ZBBX_uc011bpc.1_Missense_Mutation_p.C157S|ZBBX_uc003feq.2_Missense_Mutation_p.C128S	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	157	B box-type; atypical.					intracellular	zinc ion binding			ovary(2)	2						TTAGCAAAGCATCCTGAACAA	0.294													6	370					0	0	0	0	T	167068267	T	T	167068267	3	4	45	1	0	0	0	0	1	0	0	0	17584	217	8	5	1985	5	ZBBX	3	167068267	Missense_Mutation	SNP	A	TCGA-CN-4734-01A-01D-1434-08	39769635	167068267	30954163	39	9264											
NOP14	8602	broad.mit.edu	37	chr4	2948177	2948177	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgccgcccggcctttggtctCaatcatttcttccatctcat	5	15	6	15	2	4	0	3	0	3	0	7	0	5	0	4	2	1	0	4	2	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:2948177C>G	uc003ggj.1	-	11	1669	c.1597G>C	c.(1597-1599)GAG>CAG	p.E533Q	C4orf10_uc003gge.1_Intron|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.E279Q|NOP14_uc003ggk.3_Missense_Mutation_p.E533Q|NOP14_uc003ggl.2_Missense_Mutation_p.E533Q	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	533					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						CCTTTGGTCTCAATCATTTCT	0.488													29	81					0	0	0	0	G	2948177	G	G	2948177	3	3	45	1	0	0	0	0	1	0	0	0	10590	835	29	2	1008	2	NOP14	4	2948177	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08		2948177	188206099	40	9265											
ARAP2	116984	broad.mit.edu	37	chr4	36148978	36148979	+	Frame_Shift_Ins	INS	-	T	T																															attttgaaccattgtgctgaINSttgctgaagggagaatgaaa																								rs148742461	by1000genomes	TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:36148978_36148979insT	uc003gsq.1	-	19	3540_3541	c.3202_3203insA	c.(3202-3204)ATCfs	p.I1068fs		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1068	PH 4.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CATTGTGCTGATTGCTGAAGGG	0.332													---	---	---								T	36148979	T	T	36148978	7	5	45	1	0	1	1	0	0	0	0	0	839	333	12	0	1971	0	ARAP2	4	36148978	Frame_Shift_Ins	INS	-	TCGA-CN-4734-01A-01D-1434-08	33200801	36148978	155005298	41	9266											
EPHA5	2044	broad.mit.edu	37	chr4	66230776	66230776	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggatgatgttaggatgaTcaaactgtcccatgatactt	13	13	9	6	0	1	3	1	3	0	0	2	5	2	5	1	2	2	1	1	2	4	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:66230776T>G	uc003hcy.2	-	12	2388	c.2195A>C	c.(2194-2196)GAT>GCT	p.D732A	EPHA5_uc003hcx.2_Missense_Mutation_p.D664A|EPHA5_uc003hcz.2_Missense_Mutation_p.D710A|EPHA5_uc011cah.1_Missense_Mutation_p.D733A|EPHA5_uc011cai.1_Missense_Mutation_p.D711A|EPHA5_uc003hda.2_Missense_Mutation_p.D733A	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	732	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GTTAGGATGATCAAACTGTCC	0.373										TSP Lung(17;0.13)			46	177					0	0	0	0	G	66230776	G	G	66230776	3	3	45	1	0	0	0	0	1	0	0	0	5194	1435	50	5	946	5	EPHA5	4	66230776	Missense_Mutation	SNP	T	TCGA-CN-4734-01A-01D-1434-08	30081798	66230776	124923500	42	9267											
HERC3	8916	broad.mit.edu	37	chr4	89583679	89583679	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtttggagacaaaaactctCagaacacaacaatgcaaata	20	7	6	8	0	1	2	1	0	1	2	2	3	1	2	0	1	4	2	0	1	7	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:89583679C>G	uc003hrw.1	+	11	1410	c.1244C>G	c.(1243-1245)TCA>TGA	p.S415*	HERC3_uc011cdn.1_Nonsense_Mutation_p.S297*|HERC3_uc011cdo.1_Intron	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	415					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		CAAAAACTCTCAGAACACAAC	0.348													21	55					0	0	0	0	G	89583679	G	G	89583679	4	3	45	1	0	0	0	0	0	1	0	0	7098	838	29	2	1278	2	HERC3	4	89583679	Nonsense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	23352903	89583679	101570597	43	9268											
NDST3	9348	broad.mit.edu	37	chr4	119059259	119059259	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgtggcccctcaccattcGggcgtctaccctgtacatgt	5	11	10	15	2	2	0	1	0	1	0	3	0	2	0	4	2	2	2	4	2	2	3	rs142162150		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:119059259G>T	uc003ibx.2	+	5	1678	c.1275G>T	c.(1273-1275)TCG>TCT	p.S425S	NDST3_uc011cgf.1_Silent_p.S344S	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	425	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						CTCACCATTCGGGCGTCTACC	0.473													32	119					6.03168e-27	6.69517e-27	1	0	T	119059259	T	T	119059259	2	4	45	1	0	0	0	0	0	0	0	1	10311	1103	39	3		3	NDST3	4	119059259	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	29475580	119059259	72095017	44	9269											
SPRY1	10252	broad.mit.edu	37	chr4	124323279	124323279	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaggacctgacacagcacaAgttcatttgtgaacagtgtg	13	9	11	8	0	1	3	1	2	0	1	1	4	1	4	1	1	2	2	1	1	2	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:124323279A>G	uc003ifa.2	+	2	721	c.533A>G	c.(532-534)AAG>AGG	p.K178R	SPRY1_uc003ifb.2_Missense_Mutation_p.K178R	NM_199327	NP_955359	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling	178					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				skin(2)|ovary(1)	3						ACACAGCACAAGTTCATTTGT	0.527													35	84					0	0	0	0	G	124323279	G	G	124323279	3	3	45	1	0	0	0	0	1	0	0	0	15171	72	3	5	535	5	SPRY1	4	124323279	Missense_Mutation	SNP	A	TCGA-CN-4734-01A-01D-1434-08	5264020	124323279	66830997	45	9270											
DDX60L	91351	broad.mit.edu	37	chr4	169341482	169341482	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagttctgccggcaggcaacGttttagtaaaacgattctca	11	11	10	9	3	2	0	1	0	2	0	3	2	2	0	1	2	3	5	1	2	4	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:169341482G>A	uc003irq.3	-	18	2665	c.2444C>T	c.(2443-2445)ACG>ATG	p.T815M	DDX60L_uc003irr.1_Missense_Mutation_p.T815M|DDX60L_uc003irs.1_Missense_Mutation_p.T542M	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	815	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		GGCAGGCAACGTTTTAGTAAA	0.363													5	31					0	0	0	0	A	169341482	A	A	169341482	3	1	45	1	0	0	0	0	1	0	0	0	4396	1145	40	1	2760	1	DDX60L	4	169341482	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	45018203	169341482	21812794	46	9271											
IRF2	3660	broad.mit.edu	37	chr4	185311904	185311904	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actatcagtcgtttcgctttCtgttcacagagagaaaaaca	13	12	7	9	2	3	2	2	0	1	2	5	3	3	2	0	0	1	3	0	0	3	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:185311904C>G	uc003iwf.3	-	8	895	c.695_splice	c.e8-1	p.E232_splice		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2						blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		GTTTCGCTTTCTGTTCACAGA	0.532													27	72					0	0	0	0	G	185311904	G	G	185311904	5	3	45	1	0	0	0	0	0	0	1	0	7867	927	32	2	363	2	IRF2	4	185311904	Splice_Site	SNP	C	TCGA-CN-4734-01A-01D-1434-08	15970422	185311904	5842372	47	9272											
NIPBL	25836	broad.mit.edu	37	chr5	36986387	36986387	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacctatcaagaataaaccAtcaaagtcaaataaaggtaa	23	7	4	7	0	3	1	3	0	0	1	3	1	3	1	2	1	2	1	2	1	11	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:36986387A>G	uc003jkl.3	+	10	3604	c.3105A>G	c.(3103-3105)CCA>CCG	p.P1035P	NIPBL_uc003jkk.3_Silent_p.P1035P|NIPBL_uc003jkm.1_Silent_p.P914P	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1035					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AGAATAAACCATCAAAGTCAA	0.274													36	102					0	0	0	0	G	36986387	G	G	36986387	2	3	45	1	0	0	0	0	0	0	0	1	10482	204	8	5		5	NIPBL	5	36986387	Silent	SNP	A	TCGA-CN-4734-01A-01D-1434-08		36986387	143928873	48	9273											
DAB2	1601	broad.mit.edu	37	chr5	39382739	39382739	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttagcagtccttctgcctCttcctggtttggtactttgt	3	18	8	12	0	2	0	0	0	2	0	4	0	4	0	4	2	3	3	4	2	2	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:39382739C>G	uc003jlx.2	-	10	1853	c.1322G>C	c.(1321-1323)AGA>ACA	p.R441T	DAB2_uc003jlw.2_Missense_Mutation_p.R420T	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	441					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CCTTCTGCCTCTTCCTGGTTT	0.483													45	149					0	0	0	0	G	39382739	G	G	39382739	3	3	45	1	0	0	0	0	1	0	0	0	4235	913	32	2	1010	2	DAB2	5	39382739	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	2396352	39382739	141532521	49	9274											
F2RL1	2150	broad.mit.edu	37	chr5	76128686	76128686	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaattgtctacacaattgTgtttgtggtgggtttgccaa	8	16	10	7	0	1	0	0	0	1	0	2	0	2	0	2	2	2	2	2	2	4	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:76128686T>C	uc003keo.2	+	2	429	c.254T>C	c.(253-255)GTG>GCG	p.V85A		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	85	Helical; Name=1; (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		TACACAATTGTGTTTGTGGTG	0.463													59	189					0	0	0	0	C	76128686	C	C	76128686	3	2	45	1	0	0	0	0	1	0	0	0	5369	1696	59	5	260	5	F2RL1	5	76128686	Missense_Mutation	SNP	T	TCGA-CN-4734-01A-01D-1434-08	36745947	76128686	104786574	50	9275											
ZFYVE16	9765	broad.mit.edu	37	chr5	79743947	79743947	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taattcagagtcctatttctCaggttccatcagtggaaaaa	13	13	7	8	0	3	1	3	0	1	1	6	2	5	2	2	2	0	1	2	2	4	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:79743947C>G	uc003kgr.3	+	8	3129	c.2827C>G	c.(2827-2829)CAG>GAG	p.Q943E	ZFYVE16_uc003kgp.2_Missense_Mutation_p.Q943E|ZFYVE16_uc003kgq.3_Missense_Mutation_p.Q943E|ZFYVE16_uc003kgs.3_Missense_Mutation_p.Q943E|ZFYVE16_uc003kgt.3_Intron	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	943					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TCCTATTTCTCAGGTTCCATC	0.373													27	95					0	0	0	0	G	79743947	G	G	79743947	3	3	45	1	0	0	0	0	1	0	0	0	17731	827	29	2	2849	2	ZFYVE16	5	79743947	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	3615261	79743947	101171313	51	9276											
RASGRF2	5924	broad.mit.edu	37	chr5	80422959	80422959	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttgcaatagccacagctgCagcaggacatgggagtccac	11	8	11	11	0	0	0	0	0	0	0	1	2	1	2	2	2	5	4	2	2	2	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:80422959C>A	uc003kha.1	+	17	2663	c.2663C>A	c.(2662-2664)GCA>GAA	p.A888E	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	888					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		GCCACAGCTGCAGCAGGACAT	0.498													10	53					1.61879e-10	1.69515e-10	1	0	A	80422959	A	A	80422959	3	1	45	1	0	0	0	0	1	0	0	0	13138	710	25	4	2729	4	RASGRF2	5	80422959	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	679012	80422959	100492301	52	9277											
ERAP1	51752	broad.mit.edu	37	chr5	96136692	96136692	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtgggttcaaattgtgttGatgctagtatcctaaaatta	12	15	9	5	0	1	1	1	1	0	0	2	1	2	1	1	1	1	4	1	1	6	7			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:96136692G>A	uc003kmm.2	-	3	883	c.536C>T	c.(535-537)TCA>TTA	p.S179L	ERAP1_uc003kml.2_Missense_Mutation_p.S179L|ERAP1_uc010jbm.1_5'UTR|ERAP1_uc003kmn.2_Missense_Mutation_p.S179L	NM_001040458	NP_001035548	Q9NZ08	ERAP1_HUMAN	type 1 tumor necrosis factor receptor shedding	179	Lumenal (Potential).				angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		AAATTGTGTTGATGCTAGTAT	0.378													23	95					0	0	0	0	A	96136692	A	A	96136692	3	1	45	1	0	0	0	0	1	0	0	0	5227	1294	45	2	2390	2	ERAP1	5	96136692	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	15713733	96136692	84778568	53	9278											
BRD8	10902	broad.mit.edu	37	chr5	137486496	137486496	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagggagctgaagccacctCtggctttccattttctccca	7	12	9	13	0	2	2	0	2	2	0	4	3	3	3	4	2	2	2	4	2	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:137486496C>G	uc003lcf.1	-	22	3113	c.3058G>C	c.(3058-3060)GAG>CAG	p.E1020Q	BRD8_uc003lcc.1_Intron	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	1020					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GAAGCCACCTCTGGCTTTCCA	0.463													49	154					0	0	0	0	G	137486496	G	G	137486496	3	3	45	1	0	0	0	0	1	0	0	0	1511	922	32	2	673	2	BRD8	5	137486496	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	41349804	137486496	43428764	54	9279											
EGR1	1958	broad.mit.edu	37	chr5	137802445	137802445	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcttctctctctcctgccaGagtcttttcctgacatctct	4	16	5	16	1	4	2	0	1	4	1	9	2	6	2	3	0	1	1	3	0	0	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:137802445G>C	uc003ldb.1	+	2	578	c.308_splice	c.e2-1	p.E103_splice	EGR1_uc011cyu.1_Splice_Site_p.E103_splice	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1						cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			TCTCCTGCCAGAGTCTTTTCC	0.592													68	280					0	0	0	0	C	137802445	C	C	137802445	5	2	45	1	0	0	0	0	0	0	1	0	4993	956	33	2	313	2	EGR1	5	137802445	Splice_Site	SNP	G	TCGA-CN-4734-01A-01D-1434-08	315949	137802445	43112815	55	9280											
DNAJC18	202052	broad.mit.edu	37	chr5	138773229	138773229	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttctgggtatttgtttcttCtaactgcgtcaatgtaagct	7	18	8	8	1	4	0	1	0	3	0	4	0	4	0	0	1	3	4	0	1	4	7			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:138773229C>T	uc003len.2	-	2	64	c.59G>A	c.(58-60)AGA>AAA	p.R20K	DNAJC18_uc010jff.2_Missense_Mutation_p.R20K	NM_152686	NP_689899	Q9H819	DJC18_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 18	20					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)|kidney(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTTGTTTCTTCTAACTGCGTC	0.478													25	96					0	0	0	0	T	138773229	T	T	138773229	3	4	45	1	0	0	0	0	1	0	0	0	4659	913	32	2	1045	2	DNAJC18	5	138773229	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	970784	138773229	42142031	56	9281											
NRG2	9542	broad.mit.edu	37	chr5	139422206	139422206	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacccgaggcgggcggctctCgggtgctgttggagctggag	4	7	20	10	4	1	0	0	0	1	0	2	4	1	2	1	6	2	4	1	6	0	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:139422206C>A	uc003lex.1	-	1	674	c.449G>T	c.(448-450)CGA>CTA	p.R150L	NRG2_uc003lev.1_Missense_Mutation_p.R150L|NRG2_uc003lew.1_Missense_Mutation_p.R150L|NRG2_uc003ley.1_Missense_Mutation_p.R150L	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	150	Extracellular (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGGCTCTCGGGTGCTGTT	0.697													3	17					2.56e-06	2.63111e-06	1	0	A	139422206	A	A	139422206	3	1	45	1	0	0	0	0	1	0	0	0	10702	884	31	3	2234	3	NRG2	5	139422206	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	648977	139422206	41493054	57	9282											
PCDHB12	56124	broad.mit.edu	37	chr5	140590604	140590604	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctcggtgctcctgttcGtggcggtgcggctgtgcagg	1	13	16	11	4	2	0	0	0	2	0	5	0	3	0	1	5	3	4	1	5	0	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:140590604G>A	uc003liz.2	+	1	2314	c.2125G>A	c.(2125-2127)GTG>ATG	p.V709M	PCDHB12_uc011dak.1_Missense_Mutation_p.V372M|PCDHB13_uc003lja.1_5'Flank	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	709	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCCTGTTCGTGGCGGTGCG	0.697													44	199					0	0	0	0	A	140590604	A	A	140590604	3	1	45	1	0	0	0	0	1	0	0	0	11591	1145	40	1	2127	1	PCDHB12	5	140590604	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	1168398	140590604	40324656	58	9283											
FBXO38	81545	broad.mit.edu	37	chr5	147796565	147796565	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttgccttagggttgtgcTcgagttggtctgagtgcagg	4	15	16	6	1	1	1	0	1	1	0	2	2	1	1	1	3	3	5	1	3	1	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:147796565T>G	uc003lpf.1	+	12	1536	c.1416T>G	c.(1414-1416)GCT>GCG	p.A472A	FBXO38_uc003lpg.1_Silent_p.A472A|FBXO38_uc003lph.2_Silent_p.A472A	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	472						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGGTTGTGCTCGAGTTGGTC	0.373													18	50					0	0	0	0	G	147796565	G	G	147796565	2	3	45	1	0	0	0	0	0	0	0	1	5778	1538	54	5		5	FBXO38	5	147796565	Silent	SNP	T	TCGA-CN-4734-01A-01D-1434-08	7205961	147796565	33118695	59	9284											
NIPAL4	348938	broad.mit.edu	37	chr5	156895764	156895764	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttgccaactttggagcctaCgcatttgcacctgcaacagt	9	11	9	12	1	0	0	0	0	0	0	0	1	0	1	3	1	7	4	3	1	3	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:156895764C>T	uc003lwx.3	+	4	671	c.555C>T	c.(553-555)TAC>TAT	p.Y185Y	ADAM19_uc003lww.1_Intron|NIPAL4_uc011ddq.1_Silent_p.Y166Y|NIPAL4_uc010jin.1_3'UTR	NM_001099287	NP_001092757	Q0D2K0	NIPA4_HUMAN	ichthyin protein	185	Helical; (Potential).					integral to membrane	receptor activity				0						TTGGAGCCTACGCATTTGCAC	0.507													36	96					0	0	0	0	T	156895764	T	T	156895764	2	4	45	1	0	0	0	0	0	0	0	1	10481	547	19	1		1	NIPAL4	5	156895764	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	9099199	156895764	24019496	60	9285											
MGAT4B	11282	broad.mit.edu	37	chr5	179228838	179228838	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctcgcagcgcctgcctttCtgacacggccctcttgatct	4	12	9	16	3	4	2	0	2	4	0	5	2	4	2	3	1	2	1	3	1	0	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:179228838C>G	uc003mks.2	-	2	598	c.229G>C	c.(229-231)GAA>CAA	p.E77Q	MGAT4B_uc003mkp.2_5'Flank|MGAT4B_uc003mkq.2_5'UTR|MGAT4B_uc003mkr.2_Missense_Mutation_p.E92Q	NM_014275	NP_055090	Q9UQ53	MGT4B_HUMAN	alpha-1,3-mannosyl-glycoprotein	77	Potential.|Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding				0	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCTGCCTTTCTGACACGGCC	0.672											OREG0017110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	35					0	0	0	0	G	179228838	G	G	179228838	3	3	45	1	0	0	0	0	1	0	0	0	9599	922	32	2	1473	2	MGAT4B	5	179228838	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	22333074	179228838	1686422	61	9286											
PRL	5617	broad.mit.edu	37	chr6	22294711	22294711	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggcgcggtcaaacaggtctCgaagggtcacctggcatcgg	8	6	15	12	5	3	0	2	0	1	0	5	1	3	0	1	6	1	1	1	6	2	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:22294711C>T	uc003ndp.2	-	2	650	c.131G>A	c.(130-132)CGA>CAA	p.R44Q	PRL_uc003ndo.2_Missense_Mutation_p.R45Q|PRL_uc003ndq.2_Missense_Mutation_p.R44Q|PRL_uc003ndr.1_RNA	NM_000948	NP_000939	P01236	PRL_HUMAN	prolactin precursor	44					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding				0	Ovarian(93;0.163)					AAACAGGTCTCGAAGGGTCAC	0.602													12	33					0	0	0	0	T	22294711	T	T	22294711	3	4	45	1	0	0	0	0	1	0	0	0	12590	884	31	1	568	1	PRL	6	22294711	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08		22294711	148820356	62	9287											
HIST1H1E	3008	broad.mit.edu	37	chr6	26156774	26156774	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagctgttgccgcctccaaGgagcgcagcggcgtatcttt	8	9	12	12	4	1	0	0	0	1	0	2	1	2	1	3	2	4	4	3	2	3	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:26156774G>A	uc003ngq.2	+	1	216	c.156G>A	c.(154-156)AAG>AAA	p.K52K	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	52	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						CCGCCTCCAAGGAGCGCAGCG	0.607													7	56					0	0	0	0	A	26156774	A	A	26156774	2	1	45	1	0	0	0	0	0	0	0	1	7165	991	35	4		4	HIST1H1E	6	26156774	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	3862063	26156774	144958293	63	9288											
DST	667	broad.mit.edu	37	chr6	56443679	56443679	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatctaaaagcacttcagcCgttttcttcagtttctctac	9	15	5	12	1	5	0	2	0	3	0	6	0	5	0	1	0	3	4	1	0	3	7			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:56443679C>T	uc003pdf.2	-	44	6631	c.6603G>A	c.(6601-6603)ACG>ACA	p.T2201T	DST_uc003pcz.3_Silent_p.T2023T|DST_uc011dxj.1_Silent_p.T2052T|DST_uc011dxk.1_Silent_p.T2063T|DST_uc003pcy.3_Silent_p.T1697T|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4109	Spectrin 3.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GCACTTCAGCCGTTTTCTTCA	0.413													7	22					0	0	0	0	T	56443679	T	T	56443679	2	4	45	1	0	0	0	0	0	0	0	1	4805	639	23	1		1	DST	6	56443679	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	30286905	56443679	114671388	64	9289											
BAI3	577	broad.mit.edu	37	chr6	70098604	70098604	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttctcaacaggaaaaccccGcaccaaacaagaatccatgg	16	5	6	14	1	1	1	1	0	1	1	3	2	2	2	4	2	3	1	4	2	6	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:70098604G>A	uc003pev.3	+	32	4838	c.4390G>A	c.(4390-4392)GCA>ACA	p.A1464T	BAI3_uc010kak.2_Missense_Mutation_p.A1464T|BAI3_uc011dxx.1_Missense_Mutation_p.A670T	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1464	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GGAAAACCCCGCACCAAACAA	0.448													9	31					0	0	0	0	A	70098604	A	A	70098604	3	1	45	1	0	0	0	0	1	0	0	0	1302	1087	38	1	4508	1	BAI3	6	70098604	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	13654925	70098604	101016463	65	9290											
EEF1A1	1915	broad.mit.edu	37	chr6	74228304	74228304	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gggtttgagaacaccagtctCcactcggccaacaggaacag	12	6	11	12	1	1	1	0	1	1	1	3	3	1	2	3	3	3	1	3	3	3	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:74228304C>G	uc003phi.2	-	5	839	c.802G>C	c.(802-804)GAG>CAG	p.E268Q	EEF1A1_uc003phd.2_5'UTR|EEF1A1_uc003phe.2_Missense_Mutation_p.E258Q|EEF1A1_uc003phf.2_Missense_Mutation_p.E268Q|EEF1A1_uc003phg.2_Missense_Mutation_p.E268Q|EEF1A1_uc003phh.2_Missense_Mutation_p.E114Q|EEF1A1_uc003phj.2_Missense_Mutation_p.E268Q|EEF1A1_uc003phk.2_Missense_Mutation_p.E268Q|EEF1A1_uc003phl.2_Intron|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	268						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						ACACCAGTCTCCACTCGGCCA	0.418											OREG0003895	type=REGULATORY REGION|Gene=D16891|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	17	77					0	0	0	0	G	74228304	G	G	74228304	3	3	45	1	0	0	0	0	1	0	0	0	4945	864	30	2	598	2	EEF1A1	6	74228304	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	4129700	74228304	96886763	66	9291											
ZNF292	23036	broad.mit.edu	37	chr6	87964636	87964636	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aataccaaattctttacgctGtgagctgttacttgtattga	11	16	7	7	1	1	2	0	2	1	0	1	2	1	2	1	0	4	4	1	0	6	8			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:87964636G>A	uc003plm.3	+	8	1330	c.1289G>A	c.(1288-1290)TGT>TAT	p.C430Y		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TCTTTACGCTGTGAGCTGTTA	0.388													10	46					0	0	0	0	A	87964636	A	A	87964636	3	1	45	1	0	0	0	0	1	0	0	0	17893	1377	48	4	1319	4	ZNF292	6	87964636	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	13736332	87964636	83150431	67	9292											
THEMIS	387357	broad.mit.edu	37	chr6	128150927	128150927	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aactgagttgagcatgatttGctcaccctgctttatgatga	10	14	9	8	0	1	5	1	5	0	0	1	5	1	5	1	0	4	4	1	0	2	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:128150927G>T	uc003qbi.2	-	4	722	c.403C>A	c.(403-405)CAA>AAA	p.Q135K	THEMIS_uc010kfa.2_Missense_Mutation_p.Q38K|THEMIS_uc011ebt.1_Missense_Mutation_p.Q135K|THEMIS_uc010kfb.2_Missense_Mutation_p.Q100K	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	135	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						AGCATGATTTGCTCACCCTGC	0.403													69	196					3.31162e-33	3.69437e-33	1	0	T	128150927	T	T	128150927	3	4	45	1	0	0	0	0	1	0	0	0	15926	1328	46	4	1659	4	THEMIS	6	128150927	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	40186291	128150927	42964140	68	9293											
SHPRH	257218	broad.mit.edu	37	chr6	146271470	146271470	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctctctttggtagggtctCaacacagggatcaatgcagg	9	10	12	10	0	3	0	2	0	2	0	5	1	3	1	1	4	2	2	1	4	3	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:146271470C>G	uc003qlf.2	-	4	1311	c.912G>C	c.(910-912)TTG>TTC	p.L304F	SHPRH_uc003qld.2_Missense_Mutation_p.L304F|SHPRH_uc003qle.2_Missense_Mutation_p.L304F|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Missense_Mutation_p.L193F|SHPRH_uc003qlk.1_Missense_Mutation_p.L304F	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	304					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GGTAGGGTCTCAACACAGGGA	0.433													3	218					0	0	0	0	G	146271470	G	G	146271470	3	3	45	1	0	0	0	0	1	0	0	0	14356	825	29	2	4291	2	SHPRH	6	146271470	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	18120543	146271470	24843597	69	9294											
MAD1L1	8379	broad.mit.edu	37	chr7	2265120	2265120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtgactcagctccatctgCattttctcccgctccacctg	5	14	6	16	1	3	1	1	1	2	0	6	1	5	1	4	0	2	3	4	0	0	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:2265120C>T	uc003slh.1	-	4	482	c.216G>A	c.(214-216)ATG>ATA	p.M72I	MAD1L1_uc003slf.1_Missense_Mutation_p.M72I|MAD1L1_uc003slg.1_Missense_Mutation_p.M72I|MAD1L1_uc010ksh.1_Missense_Mutation_p.M72I|MAD1L1_uc003sli.1_Intron|MAD1L1_uc010ksi.1_Intron|MAD1L1_uc010ksj.2_Missense_Mutation_p.M72I	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	72	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		GCTCCATCTGCATTTTCTCCC	0.587													38	93					0	0	0	0	T	2265120	T	T	2265120	3	4	45	1	0	0	0	0	1	0	0	0	9198	710	25	4	2004	4	MAD1L1	7	2265120	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08		2265120	156873543	70	9295											
SP4	6671	broad.mit.edu	37	chr7	21469033	21469033	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcaaggattggtgcaacttCaaaatcaaccacaacagcta	16	8	7	10	0	3	0	3	0	0	0	3	1	3	1	1	2	5	2	1	2	7	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:21469033C>T	uc003sva.2	+	3	431	c.250C>T	c.(250-252)CAA>TAA	p.Q84*	SP4_uc003svb.2_5'UTR	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	84					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						GGTGCAACTTCAAAATCAACC	0.433													29	69					0	0	0	0	T	21469033	T	T	21469033	4	4	45	1	0	0	0	0	0	1	0	0	15030	827	29	2	260	2	SP4	7	21469033	Nonsense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	19203913	21469033	137669630	71	9296											
STK31	56164	broad.mit.edu	37	chr7	23825188	23825188	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcaagcgtcctttggtacGttctgaggttaatgggcaga	9	11	13	8	2	1	2	0	1	1	1	2	2	2	2	1	3	3	5	1	3	3	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:23825188G>A	uc003sws.3	+	18	2307	c.2240G>A	c.(2239-2241)CGT>CAT	p.R747H	STK31_uc003swt.3_Missense_Mutation_p.R724H|STK31_uc011jze.1_Missense_Mutation_p.R747H|STK31_uc010kuq.2_Missense_Mutation_p.R724H|STK31_uc003swv.1_5'Flank	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	747	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CCTTTGGTACGTTCTGAGGTT	0.438													61	192					0	0	0	0	A	23825188	A	A	23825188	3	1	45	1	0	0	0	0	1	0	0	0	15362	1145	40	1	2310	1	STK31	7	23825188	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	2356155	23825188	135313475	72	9297											
GCK	2645	broad.mit.edu	37	chr7	44185251	44185251	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctcgcaggcgcggcgcacGatgtcgcagtcggtggtcga	5	7	16	13	8	1	0	0	0	1	0	5	2	1	0	0	4	0	3	0	4	0	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:44185251G>A	uc003tkl.2	-	9	1568	c.1098C>T	c.(1096-1098)ATC>ATT	p.I366I	GCK_uc003tkh.1_Silent_p.I39I|GCK_uc003tki.1_Silent_p.I44I|GCK_uc003tkj.1_Silent_p.I365I|GCK_uc003tkk.1_Silent_p.I367I	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	366					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						CGCGGCGCACGATGTCGCAGT	0.706													7	23					0	0	0	0	A	44185251	A	A	44185251	2	1	45	1	0	0	0	0	0	0	0	1	6328	1048	37	1		1	GCK	7	44185251	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	20360063	44185251	114953412	73	9298											
PURB	5814	broad.mit.edu	37	chr7	44924866	44924866	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcctgcgtctcttgctCgccgccgccgcgggacgcgg	2	7	14	18	8	1	0	0	0	1	0	4	1	2	1	4	2	3	2	4	2	0	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:44924866C>A	uc003tme.2	-	1	95	c.82G>T	c.(82-84)GAG>TAG	p.E28*		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	28	By similarity.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						GTCTCTTGCTCGCCGCCGCCG	0.443													4	12					2.0095e-06	2.07492e-06	1	0	A	44924866	A	A	44924866	4	1	45	1	0	0	0	0	0	1	0	0	12893	893	31	3	860	3	PURB	7	44924866	Nonsense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	739615	44924866	114213797	74	9299											
MAGI2	9863	broad.mit.edu	37	chr7	78131057	78131057	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgcaggataaggctgggaggGcatctcccctgaggcacctg	8	7	15	11	0	1	1	0	1	1	0	2	3	1	3	3	5	1	4	3	5	1	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:78131057G>A	uc003ugx.2	-	5	1056	c.802C>T	c.(802-804)CCC>TCC	p.P268S	MAGI2_uc003ugy.2_Missense_Mutation_p.P268S|MAGI2_uc011kgr.1_Missense_Mutation_p.P100S|MAGI2_uc011kgs.1_Missense_Mutation_p.P105S	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	268	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GGCTGGGAGGGCATCTCCCCT	0.498													4	94					0	0	0	0	A	78131057	A	A	78131057	3	1	45	1	0	0	0	0	1	0	0	0	9244	1203	42	4	3637	4	MAGI2	7	78131057	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	33206191	78131057	81007606	75	9300											
RUNDC3B	154661	broad.mit.edu	37	chr7	87459257	87459257	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atctctaacgtcagtggcaaGttacaagtctctaacaagct	13	11	7	10	1	3	0	1	0	2	0	5	0	3	0	0	1	4	3	0	1	6	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:87459257G>C	uc003ujb.2	+	12	1745	c.1334G>C	c.(1333-1335)AGT>ACT	p.S445T	RUNDC3B_uc011khe.1_Missense_Mutation_p.S428T|RUNDC3B_uc003ujc.2_Missense_Mutation_p.S379T|RUNDC3B_uc003ujd.2_Missense_Mutation_p.S301T	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	445										skin(1)	1	Esophageal squamous(14;0.00164)					TCAGTGGCAAGTTACAAGTCT	0.378													55	163					0	0	0	0	C	87459257	C	C	87459257	3	2	45	1	0	0	0	0	1	0	0	0	13810	1029	36	4	1380	4	RUNDC3B	7	87459257	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	9328200	87459257	71679406	76	9301											
SPDYE3	441272	broad.mit.edu	37	chr7	99917323	99917323	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttatgccgtcccatgaacccGagggccaggaagaactgctc	10	7	11	13	2	0	2	0	1	0	1	2	4	1	3	4	2	4	1	4	2	4	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:99917323G>A	uc003uug.1	+	4	591	c.351G>A	c.(349-351)CCG>CCA	p.P117P	uc011kjm.1_5'Flank	NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	494											0						CCATGAACCCGAGGGCCAGGA	0.547													37	118					0	0	0	0	A	99917323	A	A	99917323	2	1	45	1	0	0	0	0	0	0	0	1	15096	1045	37	1		1	SPDYE3	7	99917323	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	12458066	99917323	59221340	77	9302											
LAMB4	22798	broad.mit.edu	37	chr7	107752256	107752256	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaggaacttaaatcatacCattttcagattgccaccatt	15	12	5	9	0	2	1	2	0	0	1	2	3	2	2	3	1	3	0	3	1	5	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:107752256C>A	uc010ljo.1	-	4	412	c.328G>T	c.(328-330)GGT>TGT	p.G110C	LAMB4_uc003vey.2_Missense_Mutation_p.G110C	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	110	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TAAATCATACCATTTTCAGAT	0.338													40	89					6.2361e-21	6.85354e-21	1	0	A	107752256	A	A	107752256	3	1	45	1	0	0	0	0	1	0	0	0	8653	608	21	4	5081	4	LAMB4	7	107752256	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	7834933	107752256	51386407	78	9303											
CADPS2	93664	broad.mit.edu	37	chr7	122033249	122033249	+	Splice_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaataagtgaggaatacacaCgtggactcatataaagaagg	19	7	10	5	1	1	2	1	1	0	1	1	4	1	4	0	3	1	0	0	3	8	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:122033249C>T	uc010lkp.2	-	21	3171	c.3008_splice	c.e21+1	p.T1003_splice	CADPS2_uc011knx.1_Splice_Site_p.T378_splice|CADPS2_uc003vkg.3_Intron|CADPS2_uc010lkq.2_Intron	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2						exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						GGAATACACACGTGGACTCAT	0.458													8	27					0	0	0	0	T	122033249	T	T	122033249	5	4	45	1	0	0	0	0	0	0	1	0	2583	550	19	1	936	1	CADPS2	7	122033249	Splice_Site	SNP	C	TCGA-CN-4734-01A-01D-1434-08	14280993	122033249	37105414	79	9304											
TAS2R38	5726	broad.mit.edu	37	chr7	141672668	141672668	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatcacccctattttgtcGcgccacagaatcagtagggg	10	9	9	13	2	2	1	2	0	0	1	3	1	2	1	4	2	0	1	4	2	3	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:141672668G>A	uc003vwx.1	-	1	906	c.822C>T	c.(820-822)CGC>CGT	p.R274R		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	274	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					CTATTTTGTCGCGCCACAGAA	0.502													23	67					0	0	0	0	A	141672668	A	A	141672668	2	1	45	1	0	0	0	0	0	0	0	1	15641	1074	38	1		1	TAS2R38	7	141672668	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	19639419	141672668	17465995	80	9305											
RP1L1	94137	broad.mit.edu	37	chr8	10480315	10480315	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggggcttcacgctggccttCgacatcccgcaactgctgag	6	9	12	14	3	1	1	1	1	0	0	3	2	2	1	2	3	2	4	2	3	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:10480315C>T	uc003wtc.2	-	2	626	c.397G>A	c.(397-399)GAA>AAA	p.E133K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	133					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CGCTGGCCTTCGACATCCCGC	0.607													36	57					0	0	0	0	T	10480315	T	T	10480315	3	4	45	1	0	0	0	0	1	0	0	0	13598	893	31	1	6817	1	RP1L1	8	10480315	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08		10480315	135883707	81	9306											
FDFT1	2222	broad.mit.edu	37	chr8	11679320	11679320	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgattgccgacatttgccGgagaatgggcattgggatgg	9	10	16	6	2	0	2	0	1	0	1	0	5	0	3	2	4	2	1	2	4	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:11679320G>A	uc003wui.2	+	4	595	c.443G>A	c.(442-444)CGG>CAG	p.R148Q	FDFT1_uc003wuh.2_Missense_Mutation_p.R84Q|FDFT1_uc010lsa.1_Missense_Mutation_p.R63Q|FDFT1_uc011kxe.1_Missense_Mutation_p.R84Q|FDFT1_uc011kxf.1_Intron|FDFT1_uc011kxg.1_Intron|FDFT1_uc003wuj.2_Missense_Mutation_p.R141Q|FDFT1_uc010lsb.2_Missense_Mutation_p.R84Q|FDFT1_uc011kxh.1_Missense_Mutation_p.R84Q|FDFT1_uc011kxi.1_RNA|FDFT1_uc011kxj.1_Missense_Mutation_p.R84Q|FDFT1_uc003wuk.2_Missense_Mutation_p.R207Q|FDFT1_uc011kxk.1_Missense_Mutation_p.R63Q	NM_004462	NP_004453	P37268	FDFT_HUMAN	squalene synthase	148					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity				0	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		GACATTTGCCGGAGAATGGGC	0.423													4	200					0	0	0	0	A	11679320	A	A	11679320	3	1	45	1	0	0	0	0	1	0	0	0	5834	1116	39	1	457	1	FDFT1	8	11679320	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	1199005	11679320	134684702	82	9307											
DLC1	10395	broad.mit.edu	37	chr8	12957760	12957760	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctcttgcaagatgggccCgctgatgatcaaccccagct	8	8	9	16	1	2	3	1	2	1	1	2	3	2	3	5	1	3	3	5	1	2	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:12957760C>T	uc003wwm.2	-	9	2530	c.2086G>A	c.(2086-2088)GGG>AGG	p.G696R	DLC1_uc003wwk.1_Missense_Mutation_p.G259R|DLC1_uc003wwl.1_Missense_Mutation_p.G293R|DLC1_uc011kxx.1_Missense_Mutation_p.G185R	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	696					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						AAGATGGGCCCGCTGATGATC	0.572													92	110					0	0	0	0	T	12957760	T	T	12957760	3	4	45	1	0	0	0	0	1	0	0	0	4572	652	23	1	2540	1	DLC1	8	12957760	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	1278440	12957760	133406262	83	9308											
TRIM35	23087	broad.mit.edu	37	chr8	27145246	27145246	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaagacagctcgccctcctCacactccagctccacacgca	11	5	6	19	2	1	1	1	0	0	1	5	2	4	1	4	0	2	3	4	0	1	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:27145246C>T	uc003xfl.1	-	6	1385	c.1303G>A	c.(1303-1305)GAG>AAG	p.E435K	TRIM35_uc010lup.1_3'UTR	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	435	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		TCGCCCTCCTCACACTCCAGC	0.682													5	10					0	0	0	0	T	27145246	T	T	27145246	3	4	45	1	0	0	0	0	1	0	0	0	16576	835	29	2	182	2	TRIM35	8	27145246	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	14187486	27145246	119218776	84	9309											
RSPO2	340419	broad.mit.edu	37	chr8	108913336	108913336	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtctgtagctaggaagacGctgtgttgctcctgggccct	5	12	13	11	1	1	1	0	0	1	1	2	2	2	2	2	2	2	5	2	2	3	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:108913336G>T	uc003yms.2	-	6	1357	c.699C>A	c.(697-699)AGC>AGA	p.S233R	RSPO2_uc003ymq.2_Missense_Mutation_p.S166R|RSPO2_uc003ymr.2_Missense_Mutation_p.S169R	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	233					Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CTAGGAAGACGCTGTGTTGCT	0.353													22	147					5.35356e-11	5.65948e-11	1	0	T	108913336	T	T	108913336	3	4	45	1	0	0	0	0	1	0	0	0	13775	1078	38	3	36	3	RSPO2	8	108913336	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	81768090	108913336	37450686	85	9310											
TNFRSF11B	4982	broad.mit.edu	37	chr8	119938851	119938851	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcctctctacactctctgcGtttactttggtgccaggcaa	7	14	7	13	1	2	0	0	0	2	0	5	0	3	0	2	2	4	2	2	2	3	4	rs150457771		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:119938851G>A	uc003yon.3	-	4	1022	c.699C>T	c.(697-699)AAC>AAT	p.N233N	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	233	Death 1.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			CACTCTCTGCGTTTACTTTGG	0.443													52	201					0	0	0	0	A	119938851	A	A	119938851	2	1	45	1	0	0	0	0	0	0	0	1	16351	1136	40	1		1	TNFRSF11B	8	119938851	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	11025515	119938851	26425171	86	9311											
KCNQ3	3786	broad.mit.edu	37	chr8	133144493	133144493	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttctgatgtggatggtctGgctacatatggttcattcct	7	17	10	7	0	3	1	1	1	2	0	4	2	4	2	1	4	1	2	1	4	2	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:133144493G>C	uc003ytj.2	-	14	2043	c.1818C>G	c.(1816-1818)GCC>GCG	p.A606A	KCNQ3_uc010mdt.2_Silent_p.A594A	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	606					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TGGATGGTCTGGCTACATATG	0.403													57	71					0	0	0	0	C	133144493	C	C	133144493	2	2	45	1	0	0	0	0	0	0	0	1	8123	1335	47	4		4	KCNQ3	8	133144493	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	13205642	133144493	13219529	87	9312											
TG	7038	broad.mit.edu	37	chr8	133978843	133978843	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcccctgtggacctcaacCaggtcattgtcaatggaaat	10	11	8	12	0	4	0	3	0	1	0	5	2	4	2	4	3	1	0	4	3	3	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:133978843C>A	uc003ytw.2	+	30	5628	c.5587C>A	c.(5587-5589)CAG>AAG	p.Q1863K	TG_uc010mdw.2_Missense_Mutation_p.Q622K|TG_uc011ljb.1_Missense_Mutation_p.Q232K|TG_uc011ljc.1_Missense_Mutation_p.Q17K|TG_uc010mdx.1_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1863	Type IIIB.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGACCTCAACCAGGTCATTGT	0.453													35	155					2.52637e-11	2.68352e-11	1	0	A	133978843	A	A	133978843	3	1	45	1	0	0	0	0	1	0	0	0	15879	595	21	4	5705	4	TG	8	133978843	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	834350	133978843	12385179	88	9313											
CYP11B1	1584	broad.mit.edu	37	chr8	143956467	143956467	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcacgtggtagaagttcctgCcggagcccctgatgtctagc	7	9	13	12	2	1	2	0	1	1	1	2	3	2	3	4	2	3	3	4	2	3	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:143956467C>T	uc003yxi.2	-	8	1311	c.1304G>A	c.(1303-1305)GGC>GAC	p.G435D	CYP11B1_uc010mex.2_Missense_Mutation_p.G134D|CYP11B1_uc003yxh.2_Intron|CYP11B1_uc003yxj.2_Intron|CYP11B1_uc010mey.2_Missense_Mutation_p.G506D	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	435					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GAAGTTCCTGCCGGAGCCCCT	0.637									Familial_Hyperaldosteronism_type_I				59	110					0	0	0	0	T	143956467	T	T	143956467	3	4	45	1	0	0	0	0	1	0	0	0	4162	739	26	4	215	4	CYP11B1	8	143956467	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	9977624	143956467	2407555	89	9314											
PLEC	5339	broad.mit.edu	37	chr8	144991583	144991583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccactcggcgcttgcgcaCggaggacttggaggacgtct	7	7	15	12	5	1	0	0	0	1	0	2	5	1	4	1	5	1	2	1	5	0	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:144991583C>T	uc003zaf.1	-	32	12987	c.12817G>A	c.(12817-12819)GTG>ATG	p.V4273M	PLEC_uc003zab.1_Missense_Mutation_p.V4136M|PLEC_uc003zac.1_Missense_Mutation_p.V4140M|PLEC_uc003zad.2_Missense_Mutation_p.V4136M|PLEC_uc003zae.1_Missense_Mutation_p.V4104M|PLEC_uc003zag.1_Missense_Mutation_p.V4114M|PLEC_uc003zah.2_Missense_Mutation_p.V4122M|PLEC_uc003zaj.2_Missense_Mutation_p.V4163M	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4273	Binding to intermediate filaments (By similarity).|Globular 2.|Plectin 27.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCTTGCGCACGGAGGACTTG	0.617													25	106					0	0	0	0	T	144991583	T	T	144991583	3	4	45	1	0	0	0	0	1	0	0	0	12107	536	19	1	1241	1	PLEC	8	144991583	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	1035116	144991583	1372439	90	9315											
SMARCA2	6595	broad.mit.edu	37	chr9	2039806	2039806	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcagcagcagcagcagcaGcagcagcagcaacagcagcc	14	0	12	15	0	0	0	0	0	0	0	0	0	0	0	1	0	13	11	1	0	1	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:2039806G>A	uc003zhc.2	+	4	795	c.696G>A	c.(694-696)CAG>CAA	p.Q232Q	SMARCA2_uc003zhd.2_Silent_p.Q232Q|SMARCA2_uc010mha.2_Silent_p.Q223Q	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	232	Poly-Gln.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		agcagcagcagcagcagcagc	0.234													2	1					0	0	0	0	A	2039806	A	A	2039806	2	1	45	1	0	0	0	0	0	0	0	1	14833	962	34	4		4	SMARCA2	9	2039806	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08		2039806	139173625	91	9316											
KIAA1432	57589	broad.mit.edu	37	chr9	5763752	5763752	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccattgtgccaggaagaccGaatatgccctgtggaattac	11	10	10	10	1	0	1	0	0	0	1	1	4	1	3	4	2	3	0	4	2	5	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:5763752G>A	uc003zji.2	+	18	2581	c.2488G>A	c.(2488-2490)GAA>AAA	p.E830K	KIAA1432_uc003zjh.2_Missense_Mutation_p.E830K|KIAA1432_uc003zjl.3_Missense_Mutation_p.E793K|KIAA1432_uc003zjj.1_Missense_Mutation_p.E372K	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	909						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CAGGAAGACCGAATATGCCCT	0.502													67	259					0	0	0	0	A	5763752	A	A	5763752	3	1	45	1	0	0	0	0	1	0	0	0	8272	1059	37	1	2558	1	KIAA1432	9	5763752	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	3723946	5763752	135449679	92	9317											
IFNA16	3449	broad.mit.edu	37	chr9	21216761	21216761	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttccttcttaatcctttttGcaagtttgttgaaaaagaga	11	17	6	7	0	1	2	0	1	1	1	3	3	3	2	2	0	1	3	2	0	4	7			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:21216761G>T	uc003zor.1	-	1	550	c.544C>A	c.(544-546)CAA>AAA	p.Q182K	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	interferon, alpha 16 precursor	182					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			skin(1)	1				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		AATCCTTTTTGCAAGTTTGTT	0.373													190	422					8.32648e-103	9.47938e-103	1	0	T	21216761	T	T	21216761	3	4	45	1	0	0	0	0	1	0	0	0	7574	1328	46	4	29	4	IFNA16	9	21216761	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	15453009	21216761	119996670	93	9318											
DMRTA1	63951	broad.mit.edu	37	chr9	22451198	22451198	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtatcgggtcatctatttCagaatactccaacaagcctg	13	11	7	10	1	3	1	2	0	1	1	5	1	4	1	2	1	3	1	2	1	7	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:22451198C>G	uc003zpp.1	+	2	1028	c.803C>G	c.(802-804)TCA>TGA	p.S268*		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	268					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		TCATCTATTTCAGAATACTCC	0.448													44	77					0	0	0	0	G	22451198	G	G	22451198	4	3	45	1	0	0	0	0	0	1	0	0	4610	838	29	2	809	2	DMRTA1	9	22451198	Nonsense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	1234437	22451198	118762233	94	9319											
DMRTA1	63951	broad.mit.edu	37	chr9	22451226	22451226	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tccaacaagcctgatagtatCctgtctcctcatcctggaga	10	11	7	13	0	2	2	1	1	1	1	6	3	5	2	5	1	2	1	5	1	4	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:22451226C>G	uc003zpp.1	+	2	1056	c.831C>G	c.(829-831)ATC>ATG	p.I277M		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	277					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		CTGATAGTATCCTGTCTCCTC	0.438													39	66					0	0	0	0	G	22451226	G	G	22451226	3	3	45	1	0	0	0	0	1	0	0	0	4610	845	30	2	837	2	DMRTA1	9	22451226	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	28	22451226	118762205	95	9320											
C9orf128	392307	broad.mit.edu	37	chr9	35825248	35825248	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctggatggcattcagggCtgcatccttctcccactgga	6	12	11	12	0	3	0	1	0	2	0	5	2	4	2	2	4	1	3	2	4	0	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:35825248C>T	uc010mlc.2	-	3	1006	c.721G>A	c.(721-723)GCC>ACC	p.A241T	C9orf128_uc003zyj.2_RNA|C9orf128_uc011lpg.1_Missense_Mutation_p.A241T	NM_001012446	NP_001012448	A6H8Z2	CI128_HUMAN	hypothetical protein LOC392307	241											0	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			GCATTCAGGGCTGCATCCTTC	0.532													49	68					0	0	0	0	T	35825248	T	T	35825248	3	4	45	1	0	0	0	0	1	0	0	0	2467	797	28	4	507	4	C9orf128	9	35825248	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	13374022	35825248	105388183	96	9321											
COL5A1	1289	broad.mit.edu	37	chr9	137591821	137591821	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagaaaggcagccaggcctTcctggtctccatctacaacg	11	7	9	14	1	2	1	0	0	2	1	4	1	3	1	4	3	3	1	4	3	4	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:137591821T>C	uc004cfe.2	+	3	726	c.344T>C	c.(343-345)TTC>TCC	p.F115S		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	115	TSP N-terminal.|Laminin G-like.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGCCAGGCCTTCCTGGTCTCC	0.587													30	93					0	0	0	0	C	137591821	C	C	137591821	3	2	45	1	0	0	0	0	1	0	0	0	3711	1783	62	5	354	5	COL5A1	9	137591821	Missense_Mutation	SNP	T	TCGA-CN-4734-01A-01D-1434-08	101766573	137591821	3621610	97	9322											
KIAA1984	84960	broad.mit.edu	37	chr9	139701274	139701274	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgtactgcgaggggaagctCacgtacctggctgacagagt	9	7	15	10	3	1	2	1	1	0	1	1	4	1	3	1	3	4	4	1	3	3	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:139701274C>T	uc004cjf.2	+	12	1392	c.1344C>T	c.(1342-1344)CTC>CTT	p.L448L	C9orf86_uc004cjm.2_5'Flank|C9orf86_uc004cjh.2_5'Flank|C9orf86_uc004cjj.1_5'Flank|C9orf86_uc004cjk.1_5'Flank|C9orf86_uc004cji.1_5'Flank|C9orf86_uc010nbr.1_5'Flank|LOC100131193_uc004cjg.1_Intron	NM_001039374	NP_001034463	Q5T5S1	K1984_HUMAN	hypothetical protein LOC84960	448										ovary(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.33e-06)|Epithelial(140;0.000124)		AGGGGAAGCTCACGTACCTGG	0.617													11	50					0	0	0	0	T	139701274	T	T	139701274	2	4	45	1	0	0	0	0	0	0	0	1	8305	813	29	2		2	KIAA1984	9	139701274	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	2109453	139701274	1512157	98	9323											
C10orf113	387638	broad.mit.edu	37	chr10	21435284	21435284	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actctacctgttcatgtctgGaatgtacatttcagccacac	10	13	6	12	0	4	0	2	0	2	0	4	1	4	1	2	1	3	2	2	1	3	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:21435284G>A	uc001iqm.2	-	1	144	c.124C>T	c.(124-126)CCA>TCA	p.P42S	NEBL_uc001iqk.2_Intron	NM_001010896	NP_001010896	Q5VZT2	CJ113_HUMAN	hypothetical protein LOC387638	52										ovary(3)|pancreas(1)	4						TTCATGTCTGGAATGTACATT	0.443													31	106					0	0	0	0	A	21435284	A	A	21435284	3	1	45	1	0	0	0	0	1	0	0	0	1590	1174	41	2	356	2	C10orf113	10	21435284	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08		21435284	114099463	99	9324											
CYP26A1	1592	broad.mit.edu	37	chr10	94834671	94834671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaccccgaggtgaagcgcCtcatgttccgaatcgccatg	8	9	10	14	4	2	1	1	1	1	0	4	3	3	1	5	1	2	1	5	1	3	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:94834671C>T	uc001kil.2	+	3	595	c.550C>T	c.(550-552)CTC>TTC	p.L184F	CYP26A1_uc001kik.1_Missense_Mutation_p.L115F|CYP26A1_uc001kim.1_Missense_Mutation_p.L82F	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	184					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)				GGTGAAGCGCCTCATGTTCCG	0.652													3	105					0	0	0	0	T	94834671	T	T	94834671	3	4	45	1	0	0	0	0	1	0	0	0	4172	681	24	4	560	4	CYP26A1	10	94834671	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	73399387	94834671	40700076	100	9325											
TM9SF3	56889	broad.mit.edu	37	chr10	98312702	98312702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccatatcatccatttcttCctctttactgtaccgagcat	9	15	3	14	1	3	0	1	0	2	0	5	1	5	0	4	0	3	2	4	0	3	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:98312702C>T	uc001kmm.3	-	6	992	c.775G>A	c.(775-777)GAA>AAA	p.E259K	TM9SF3_uc010qot.1_Missense_Mutation_p.E259K|TM9SF3_uc001kmn.1_Missense_Mutation_p.E28K	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	259						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TCCATTTCTTCCTCTTTACTG	0.294													16	45					0	0	0	0	T	98312702	T	T	98312702	3	4	45	1	0	0	0	0	1	0	0	0	16045	864	30	2	1034	2	TM9SF3	10	98312702	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	3478031	98312702	37222045	101	9326											
FAM196A	642938	broad.mit.edu	37	chr10	128974488	128974488	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctgtgtgtccctctgctCattctgtgcctcgcagatat	5	14	9	13	1	3	1	1	0	2	1	5	1	4	1	2	0	3	3	2	0	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:128974488C>A	uc001lju.1	-	1	213	c.172G>T	c.(172-174)GAG>TAG	p.E58*	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Nonsense_Mutation_p.E58*|FAM196A_uc001ljv.1_Nonsense_Mutation_p.E58*|FAM196A_uc009yap.1_Nonsense_Mutation_p.E58*	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	58										ovary(2)	2						TCCCTCTGCTCATTCTGTGCC	0.587													56	187					4.00338e-15	4.33536e-15	1	0	A	128974488	A	A	128974488	4	1	45	1	0	0	0	0	0	1	0	0	5556	835	29	2	1279	2	FAM196A	10	128974488	Nonsense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	30661786	128974488	6560259	102	9327											
OR52B6	340980	broad.mit.edu	37	chr11	5602923	5602923	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcatcctactcttctatgtcCctgcgcttttttctgtcttt	3	21	4	13	1	5	0	1	0	4	0	7	0	7	0	2	0	2	1	2	0	2	7			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:5602923C>A	uc010qzi.1	+	1	817	c.817C>A	c.(817-819)CCT>ACT	p.P273T	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	273	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCTATGTCCCTGCGCTTTT	0.517													54	233					1.91123e-38	2.14289e-38	1	0	A	5602923	A	A	5602923	3	1	45	1	0	0	0	0	1	0	0	0	11167	623	22	4	819	4	OR52B6	11	5602923	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08		5602923	129403593	103	9328											
DNHD1	144132	broad.mit.edu	37	chr11	6540999	6540999	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctgcagctgggaaagtttgCccgcctggttgactacatga	8	10	13	10	1	0	2	0	2	0	0	0	3	0	3	2	2	4	5	2	2	2	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:6540999C>T	uc001mdw.3	+	8	2126	c.1562C>T	c.(1561-1563)GCC>GTC	p.A521V	DNHD1_uc001mdp.2_Missense_Mutation_p.A521V|DNHD1_uc001mdq.2_Missense_Mutation_p.A210V	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	521					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GGAAAGTTTGCCCGCCTGGTT	0.522													4	101					0	0	0	0	T	6540999	T	T	6540999	3	4	45	1	0	0	0	0	1	0	0	0	4690	739	26	4	1584	4	DNHD1	11	6540999	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	938076	6540999	128465517	104	9329											
IPO7	10527	broad.mit.edu	37	chr11	9430055	9430055	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttatctatctgaaaaatatGataacacagtattggcctga	15	13	7	6	0	2	3	0	3	2	0	2	3	2	3	1	1	1	2	1	1	7	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:9430055G>C	uc001mho.2	+	3	331	c.189G>C	c.(187-189)ATG>ATC	p.M63I		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	63	Importin N-terminal.				interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TGAAAAATATGATAACACAGT	0.363													20	59					0	0	0	0	C	9430055	C	C	9430055	3	2	45	1	0	0	0	0	1	0	0	0	7836	1290	45	2	199	2	IPO7	11	9430055	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	2889056	9430055	125576461	105	9330											
EIF4G2	1982	broad.mit.edu	37	chr11	10821202	10821202	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggggatggatccaactttaTttgcttcaacagttccttct	9	15	8	9	0	2	0	1	0	1	0	4	2	4	2	2	3	3	2	2	3	3	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:10821202T>C	uc001mjc.2	-	19	2638	c.2221A>G	c.(2221-2223)ATA>GTA	p.I741V	EIF4G2_uc001mjb.2_Missense_Mutation_p.I535V|EIF4G2_uc009ygf.2_Missense_Mutation_p.I535V|EIF4G2_uc001mjd.2_Missense_Mutation_p.I703V	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	741	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TCCAACTTTATTTGCTTCAAC	0.368													43	127					0	0	0	0	C	10821202	C	C	10821202	3	2	45	1	0	0	0	0	1	0	0	0	5061	1493	52	5	518	5	EIF4G2	11	10821202	Missense_Mutation	SNP	T	TCGA-CN-4734-01A-01D-1434-08	1391147	10821202	124185314	106	9331											
CYP2R1	120227	broad.mit.edu	37	chr11	14902248	14902248	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttggccatatccaaaatatCgaaaactgtttacagctaat	15	13	5	8	1	0	0	0	0	0	0	2	1	1	0	2	1	3	2	2	1	8	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:14902248C>G	uc001mlr.2	-	3	434	c.434G>C	c.(433-435)CGA>CCA	p.R145P	CYP2R1_uc001mlo.2_Intron|CYP2R1_uc001mlp.2_Missense_Mutation_p.R28P|CYP2R1_uc001mlq.2_RNA|CYP2R1_uc001mls.1_Missense_Mutation_p.R90P	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	145					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	TCCAAAATATCGAAAACTGTT	0.318													12	58					0	0	0	0	G	14902248	G	G	14902248	3	3	45	1	0	0	0	0	1	0	0	0	4190	884	31	3	1083	3	CYP2R1	11	14902248	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	4081046	14902248	120104268	107	9332											
PRG2	5553	broad.mit.edu	37	chr11	57155245	57155245	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcgggtacacagggccaCgcagtgaccaccgcgggacc	9	3	13	16	4	0	1	0	1	0	0	1	2	0	2	5	3	1	2	5	3	1	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:57155245C>T	uc001njz.2	-	4	619	c.592G>A	c.(592-594)GTG>ATG	p.V198M	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.V198M|PRG2_uc001nkb.2_Missense_Mutation_p.V198M|PRG2_uc001nkd.2_Missense_Mutation_p.V187M|PRG2_uc001nkc.2_Missense_Mutation_p.V198M|PRG2_uc001nke.2_Missense_Mutation_p.V478M	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	198	C-type lectin.				defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	CACAGGGCCACGCAGTGACCA	0.617													3	14					0	0	0	0	T	57155245	T	T	57155245	3	4	45	1	0	0	0	0	1	0	0	0	12541	536	19	1	84	1	PRG2	11	57155245	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	42252997	57155245	77851271	108	9333											
OR10W1	81341	broad.mit.edu	37	chr11	58034971	58034971	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgaggagagggtactgcaaCgggtggcaaatggccacata	13	6	15	7	1	0	2	0	1	0	1	0	3	0	2	1	5	3	3	1	5	4	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:58034971C>T	uc001nmq.1	-	1	762	c.360G>A	c.(358-360)CCG>CCA	p.P120P		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				GGTACTGCAACGGGTGGCAAA	0.532													9	36					0	0	0	0	T	58034971	T	T	58034971	2	4	45	1	0	0	0	0	0	0	0	1	10975	523	19	1		1	OR10W1	11	58034971	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	879726	58034971	76971545	109	9334											
MRGPRF	116535	broad.mit.edu	37	chr11	68772961	68772961	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacaggtcagtgacgtactCggggaagggggccgggatct	8	6	18	9	3	2	1	1	1	1	0	3	3	2	3	1	6	1	2	1	6	2	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:68772961C>T	uc001ooo.3	-	3	1184	c.817G>A	c.(817-819)GAG>AAG	p.E273K	MRGPRF_uc001oop.3_Missense_Mutation_p.E273K	NM_001098515	NP_001091985	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	273	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GTGACGTACTCGGGGAAGGGG	0.612													4	7					0	0	0	0	T	68772961	T	T	68772961	3	4	45	1	0	0	0	0	1	0	0	0	9818	893	31	1	218	1	MRGPRF	11	68772961	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	10737990	68772961	66233555	110	9335											
DYNC2H1	79659	broad.mit.edu	37	chr11	102988581	102988581	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacttgacaaacttggcaaaCgccttgaagaggtatcaatt	14	10	8	9	1	1	3	1	2	0	1	1	3	1	3	1	2	2	2	1	2	5	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:102988581C>T	uc001pho.2	+	6	1132	c.988C>T	c.(988-990)CGC>TGC	p.R330C	DYNC2H1_uc001phn.1_Missense_Mutation_p.R330C|DYNC2H1_uc009yxe.1_Missense_Mutation_p.R330C	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	330	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		ACTTGGCAAACGCCTTGAAGA	0.333													9	38					0	0	0	0	T	102988581	T	T	102988581	3	4	45	1	0	0	0	0	1	0	0	0	4868	536	19	1	1010	1	DYNC2H1	11	102988581	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	34215620	102988581	32017935	111	9336											
PHLDB1	23187	broad.mit.edu	37	chr11	118506147	118506147	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agactgagacaaagctctttGaggacttggagttccagcag	12	9	12	8	0	1	3	0	2	1	2	2	6	2	5	1	2	2	3	1	2	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:118506147G>C	uc001ptr.1	+	11	2769	c.2416G>C	c.(2416-2418)GAG>CAG	p.E806Q	PHLDB1_uc001pts.2_Missense_Mutation_p.E806Q|PHLDB1_uc001ptt.2_Missense_Mutation_p.E806Q|PHLDB1_uc001ptu.1_RNA|PHLDB1_uc001ptv.1_Missense_Mutation_p.E606Q|PHLDB1_uc001ptw.1_Missense_Mutation_p.E208Q|PHLDB1_uc009zai.1_5'UTR|PHLDB1_uc001ptx.1_5'UTR	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	806	Potential.										0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		AAAGCTCTTTGAGGACTTGGA	0.637													46	149					0	0	0	0	C	118506147	C	C	118506147	3	2	45	1	0	0	0	0	1	0	0	0	11906	1291	45	2	2450	2	PHLDB1	11	118506147	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	15517566	118506147	16500369	112	9337											
ANO2	57101	broad.mit.edu	37	chr12	5941701	5941701	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaactcggggctgcaggtgCgagctcagcttctgcagagc	7	7	16	11	2	2	1	1	0	1	1	3	3	2	2	0	4	7	5	0	4	1	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:5941701C>T	uc001qnm.2	-	5	762	c.690G>A	c.(688-690)TCG>TCA	p.S230S		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	235	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						GCTGCAGGTGCGAGCTCAGCT	0.507													18	101					0	0	0	0	T	5941701	T	T	5941701	2	4	45	1	0	0	0	0	0	0	0	1	697	755	27	1		1	ANO2	12	5941701	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08		5941701	127910194	113	9338											
IFFO1	25900	broad.mit.edu	37	chr12	6659915	6659915	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccttcaactgttccaccttCagtgccagctcctcctggca	6	11	7	17	0	2	0	2	0	0	0	5	0	5	0	6	1	3	3	6	1	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:6659915C>T	uc001qpd.1	-	3	910	c.876G>A	c.(874-876)CTG>CTA	p.L292L	IFFO1_uc001qoy.2_RNA|IFFO1_uc001qpa.1_5'Flank|IFFO1_uc001qpb.1_5'Flank|IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_Silent_p.L292L|IFFO1_uc001qpf.1_Silent_p.L292L|IFFO1_uc001qoz.1_5'Flank|IFFO1_uc001qpc.1_Silent_p.L292L|IFFO1_uc001qpg.2_5'Flank	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	292	Potential.					intermediate filament					0						GTTCCACCTTCAGTGCCAGCT	0.582													31	51					0	0	0	0	T	6659915	T	T	6659915	2	4	45	1	0	0	0	0	0	0	0	1	7549	813	29	2		2	IFFO1	12	6659915	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	718214	6659915	127191980	114	9339											
SPSB2	84727	broad.mit.edu	37	chr12	6980443	6980444	+	Frame_Shift_Del	DEL	CA	-	-																															gtatcccccaggttgtggcgCacacacaggcggctcaggtg																										TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:6980443_6980444delCA	uc001qrl.2	-	3	860_861	c.704_705delTG	c.(703-705)GTGfs	p.V235fs	SPSB2_uc001qrm.2_Frame_Shift_Del_p.V235fs|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	235	SOCS box.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1						GGTTGTGGCGCACACACAGGCG	0.624													---	---	---								-	6980444	-	-	6980443	7	5	45	1	0	1	0	1	0	0	0	0	15179	697	25	0	90	0	SPSB2	12	6980443	Frame_Shift_Del	DEL	CA	TCGA-CN-4734-01A-01D-1434-08	320528	6980443	126871452	115	9340											
FAM90A1	55138	broad.mit.edu	37	chr12	8374610	8374610	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggctggagctccagcgtccGttttccagtctccgaaagag	8	9	12	12	3	1	1	0	0	1	1	5	3	4	2	4	2	2	3	4	2	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:8374610G>A	uc001qui.2	-	7	1762	c.1203C>T	c.(1201-1203)AAC>AAT	p.N401N	FAM90A1_uc001quh.2_Silent_p.N401N	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	401							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		TCCAGCGTCCGTTTTCCAGTC	0.622													15	41					0	0	0	0	A	8374610	A	A	8374610	2	1	45	1	0	0	0	0	0	0	0	1	5682	1136	40	1		1	FAM90A1	12	8374610	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	1394167	8374610	125477285	116	9341											
LRP6	4040	broad.mit.edu	37	chr12	12284775	12284775	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcacagttcttctcatctGatttgtcctggcagtttgca	6	17	7	11	0	4	1	2	1	3	0	6	1	5	1	1	1	1	4	1	1	0	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:12284775G>A	uc001rah.3	-	18	4092	c.3950C>T	c.(3949-3951)TCA>TTA	p.S1317L	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.S1272L	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1317	LDL-receptor class A 2.|Extracellular (Potential).				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CTTCTCATCTGATTTGTCCTG	0.448													38	150					0	0	0	0	A	12284775	A	A	12284775	3	1	45	1	0	0	0	0	1	0	0	0	9012	1294	45	2	915	2	LRP6	12	12284775	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	3910165	12284775	121567120	117	9342											
PIK3C2G	5288	broad.mit.edu	37	chr12	18473914	18473914	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcatgaagaggaccacagtCagttttatctgaatcaactt	14	11	8	8	0	3	3	2	2	1	1	3	4	3	4	1	1	2	2	1	1	4	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:18473914C>G	uc001rdt.2	+	7	1272	c.1156C>G	c.(1156-1158)CAG>GAG	p.Q386E	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.Q386E|PIK3C2G_uc010sic.1_Missense_Mutation_p.Q164E	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	386					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GGACCACAGTCAGTTTTATCT	0.333													6	34					0	0	0	0	G	18473914	G	G	18473914	3	3	45	1	0	0	0	0	1	0	0	0	11966	827	29	2	1178	2	PIK3C2G	12	18473914	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	6189139	18473914	115377981	118	9343											
RECQL	5965	broad.mit.edu	37	chr12	21626554	21626554	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatacttcatcaaaatgttGagccatcaacacacgacgac	15	8	5	13	2	3	1	3	1	0	0	3	3	3	1	2	0	3	1	2	0	4	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:21626554G>C	uc001rex.2	-	13	1726	c.1378C>G	c.(1378-1380)CAA>GAA	p.Q460E	RECQL_uc001rey.2_Missense_Mutation_p.Q460E	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	460					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						TCAAAATGTTGAGCCATCAAC	0.323								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					17	57					0	0	0	0	C	21626554	C	C	21626554	3	2	45	1	0	0	0	0	1	0	0	0	13266	1299	45	2	587	2	RECQL	12	21626554	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	3152640	21626554	112225341	119	9344											
RAP1B	5908	broad.mit.edu	37	chr12	69042539	69042539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctagtcgttcttggctcagGaggcgttggaaagtctgctt	6	13	14	8	2	3	0	1	0	2	0	4	2	3	2	0	4	1	5	0	4	2	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:69042539G>A	uc001sub.2	+	2	198	c.35G>A	c.(34-36)CGA>CAA	p.R12Q	RAP1B_uc010ste.1_Intron|RAP1B_uc001suc.2_Missense_Mutation_p.G12E|RAP1B_uc010stf.1_Missense_Mutation_p.G12E|RAP1B_uc010stg.1_Missense_Mutation_p.G12E|RAP1B_uc010sth.1_Missense_Mutation_p.G12E|RAP1B_uc010sti.1_Missense_Mutation_p.G12E	NM_001089704	NP_001083173	P61224	RAP1B_HUMAN	SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;	12	GTP.				blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		CTTGGCTCAGGAGGCGTTGGA	0.363													27	46					0	0	0	0	A	69042539	A	A	69042539	3	1	45	1	0	0	0	0	1	0	0	0	13101	1174	41	2	37	2	RAP1B	12	69042539	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	47415985	69042539	64809356	120	9345											
CPM	1368	broad.mit.edu	37	chr12	69250409	69250409	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcactgaagttctgggatttCtccggaataatcacctttgt	9	14	9	9	1	3	1	1	1	2	0	4	3	3	3	2	2	0	2	2	2	3	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:69250409C>G	uc001sup.2	-	9	1201	c.1140G>C	c.(1138-1140)GAG>GAC	p.E380D	CPM_uc001sur.2_Missense_Mutation_p.E380D|CPM_uc001suq.2_Missense_Mutation_p.E380D	NM_198320	NP_938079	P14384	CBPM_HUMAN	carboxypeptidase M precursor	380					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding				0	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TCTGGGATTTCTCCGGAATAA	0.408													38	123					0	0	0	0	G	69250409	G	G	69250409	3	3	45	1	0	0	0	0	1	0	0	0	3823	912	32	2	195	2	CPM	12	69250409	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	207870	69250409	64601486	121	9346											
MYF6	4618	broad.mit.edu	37	chr12	81101864	81101864	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagcggcgaactgtggcCaaccccaaccagaggctgcc	10	4	12	15	2	0	2	0	1	0	1	0	3	0	2	5	3	5	1	5	3	4	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:81101864C>T	uc001szf.1	+	1	419	c.366C>T	c.(364-366)GCC>GCT	p.A122A		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	122	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						GAACTGTGGCCAACCCCAACC	0.617													15	103					0	0	0	0	T	81101864	T	T	81101864	2	4	45	1	0	0	0	0	0	0	0	1	10081	581	21	4		4	MYF6	12	81101864	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	11851455	81101864	52750031	122	9347											
TMTC3	160418	broad.mit.edu	37	chr12	88589182	88589182	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcccaaccagtaagatttCaagtgtggaaggaaagaaaa	18	8	9	6	0	1	2	1	0	0	2	2	4	2	4	2	2	1	1	2	2	7	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:88589182C>G	uc001tau.2	+	14	2721	c.2501C>G	c.(2500-2502)TCA>TGA	p.S834*		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	835						integral to membrane	binding			skin(1)	1						AGTAAGATTTCAAGTGTGGAA	0.338													97	120					0	0	0	0	G	88589182	G	G	88589182	4	3	45	1	0	0	0	0	0	1	0	0	16328	838	29	2	2551	2	TMTC3	12	88589182	Nonsense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	7487318	88589182	45262713	123	9348											
USP44	84101	broad.mit.edu	37	chr12	95927270	95927270	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaggagtcactgactttttGagatatttcattttctgagg	9	17	10	5	0	3	4	2	4	1	1	3	6	3	5	0	2	0	0	0	2	1	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:95927270G>A	uc001teg.2	-	2	907	c.763C>T	c.(763-765)CAA>TAA	p.Q255*	USP44_uc001teh.2_Nonsense_Mutation_p.Q255*|USP44_uc009zte.2_Nonsense_Mutation_p.Q252*	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	255					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						CTGACTTTTTGAGATATTTCA	0.388													32	206					0	0	0	0	A	95927270	A	A	95927270	4	1	45	1	0	0	0	0	0	1	0	0	17143	1299	45	2	1395	2	USP44	12	95927270	Nonsense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	7338088	95927270	37924625	124	9349											
ANO4	121601	broad.mit.edu	37	chr12	101477507	101477507	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attccaagaaagagcggatgAatccaatttctggaaagcca	16	8	9	8	1	1	3	0	1	1	2	3	5	3	5	3	2	2	0	3	2	5	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:101477507A>G	uc010svm.1	+	16	2019	c.1447A>G	c.(1447-1449)AAT>GAT	p.N483D	ANO4_uc001thw.2_Missense_Mutation_p.N448D|ANO4_uc001thx.2_Missense_Mutation_p.N483D|ANO4_uc001thy.2_Intron	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	483	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						AGAGCGGATGAATCCAATTTC	0.383										HNSCC(74;0.22)			36	178					0	0	0	0	G	101477507	G	G	101477507	3	3	45	1	0	0	0	0	1	0	0	0	699	246	9	5	1396	5	ANO4	12	101477507	Missense_Mutation	SNP	A	TCGA-CN-4734-01A-01D-1434-08	5550237	101477507	32374388	125	9350											
SYCP3	50511	broad.mit.edu	37	chr12	102127427	102127427	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacaaagtcagaaactgctGagaatattcttggttaagct	16	11	8	6	0	2	2	1	1	1	2	2	3	2	2	0	1	4	3	0	1	6	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:102127427G>C	uc001tiq.2	-	6	511	c.379C>G	c.(379-381)CAG>GAG	p.Q127E	SYCP3_uc001tir.2_Missense_Mutation_p.Q127E|SYCP3_uc001tis.2_Missense_Mutation_p.Q127E	NM_153694	NP_710161	Q8IZU3	SYCP3_HUMAN	synaptonemal complex protein 3	127	Gln-rich.				cell division|male meiosis I|spermatogenesis, exchange of chromosomal proteins	nucleus	DNA binding				0						AGAAACTGCTGAGAATATTCT	0.303													57	79					0	0	0	0	C	102127427	C	C	102127427	3	2	45	1	0	0	0	0	1	0	0	0	15500	1299	45	2	347	2	SYCP3	12	102127427	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	649920	102127427	31724468	126	9351											
MED13L	23389	broad.mit.edu	37	chr12	116457051	116457051	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggatagcctgttctggagaGgtgggaggggtcagaggcat	9	8	19	5	0	2	2	1	0	1	2	2	5	2	4	1	7	1	2	1	7	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:116457051G>A	uc001tvw.2	-	7	1042	c.987C>T	c.(985-987)ACC>ACT	p.T329T		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	329					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GTTCTGGAGAGGTGGGAGGGG	0.542													16	84					0	0	0	0	A	116457051	A	A	116457051	2	1	45	1	0	0	0	0	0	0	0	1	9484	987	35	4		4	MED13L	12	116457051	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	14329624	116457051	17394844	127	9352											
TUBA3C	7278	broad.mit.edu	37	chr13	19751261	19751261	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcattggtgatctcagccaCggacagctgctcgtggtagg	7	9	15	10	2	1	1	1	1	1	0	3	2	1	2	1	5	3	4	1	5	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr13:19751261C>T	uc009zzj.2	-	4	911	c.862G>A	c.(862-864)GTG>ATG	p.V288M		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	288					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		ATCTCAGCCACGGACAGCTGC	0.607													43	137					0	0	0	0	T	19751261	T	T	19751261	3	4	45	1	0	0	0	0	1	0	0	0	16814	536	19	1	498	1	TUBA3C	13	19751261	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08		19751261	95418617	128	9353											
EXOSC8	11340	broad.mit.edu	37	chr13	37578686	37578686	+	Frame_Shift_Del	DEL	A	-	-																															catcaacagatgcccctgatAaaggatacgttggtaagtta																										TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr13:37578686delA	uc001uwa.2	+	5	491	c.226delA	c.(226-228)AAAfs	p.K76fs	EXOSC8_uc001uvz.2_RNA|EXOSC8_uc001uwb.2_Frame_Shift_Del_p.K76fs|EXOSC8_uc001uwc.2_RNA	NM_181503	NP_852480	Q96B26	EXOS8_HUMAN	exosome component 8	76					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	AU-rich element binding|identical protein binding			pancreas(1)	1		Lung NSC(96;6.57e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.67e-07)|Epithelial(112;1.31e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00699)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0411)		TGCCCCTGATAAAGGATACGT	0.289													---	---	---								-	37578686	-	-	37578686	7	5	45	1	0	1	0	1	0	0	0	0	5345	363	13	0	244	0	EXOSC8	13	37578686	Frame_Shift_Del	DEL	A	TCGA-CN-4734-01A-01D-1434-08	17827425	37578686	77591192	129	9354											
TNFSF11	8600	broad.mit.edu	37	chr13	43180976	43180976	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagaggaaatcagcatcgaGgtctccaacccctccttact	11	8	9	13	1	2	1	1	0	1	1	5	4	3	2	4	3	3	1	4	3	3	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr13:43180976G>A	uc001uyu.2	+	5	1025	c.876G>A	c.(874-876)GAG>GAA	p.E292E	TNFSF11_uc001uyt.2_Silent_p.E219E	NM_003701	NP_003692	O14788	TNF11_HUMAN	tumor necrosis factor ligand superfamily, member	292	Extracellular (Potential).				immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding				0		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TCAGCATCGAGGTCTCCAACC	0.423													53	178					0	0	0	0	A	43180976	A	A	43180976	2	1	45	1	0	0	0	0	0	0	0	1	16368	991	35	4		4	TNFSF11	13	43180976	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	5602290	43180976	71988902	130	9355											
MYH7	4625	broad.mit.edu	37	chr14	23898464	23898464	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacattctgccccttggtgaCgtactcattgcccactttca	7	13	7	14	1	3	1	2	1	1	0	3	2	3	1	3	1	3	1	3	1	1	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:23898464C>T	uc001wjx.2	-	13	1337	c.1231G>A	c.(1231-1233)GTC>ATC	p.V411I		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	411	Myosin head-like.		V -> I (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCCTTGGTGACGTACTCATTG	0.567													145	91					0	0	0	0	T	23898464	T	T	23898464	3	4	45	1	0	0	0	0	1	0	0	0	10092	536	19	1	4688	1	MYH7	14	23898464	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08		23898464	83451076	131	9356											
FAM179B	23116	broad.mit.edu	37	chr14	45432126	45432126	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acgttctccggggtcaggggGaggcaggccagcttgaagag	8	6	18	9	2	2	2	1	1	1	1	3	3	2	3	2	6	1	3	2	6	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:45432126G>A	uc001wvv.2	+	1	711	c.502G>A	c.(502-504)GAG>AAG	p.E168K	FAM179B_uc001wvw.2_Missense_Mutation_p.E168K|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.E168K|FAM179B_uc001wvu.2_Missense_Mutation_p.E168K	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	168							binding			skin(2)|upper_aerodigestive_tract(1)	3						GGGTCAGGGGGAGGCAGGCCA	0.562													157	102					0	0	0	0	A	45432126	A	A	45432126	3	1	45	1	0	0	0	0	1	0	0	0	5534	1175	41	2	504	2	FAM179B	14	45432126	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	21533662	45432126	61917414	132	9357											
SGPP1	81537	broad.mit.edu	37	chr14	64153029	64153029	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctgattattagtacaaataCcatccctatgaggatccgca	13	12	6	10	1	1	2	0	2	1	0	3	3	3	3	3	1	2	2	3	1	6	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:64153029C>G	uc001xgj.2	-	3	1214	c.1120G>C	c.(1120-1122)GTA>CTA	p.V374L		NM_030791	NP_110418	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	374	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		AGTACAAATACCATCCCTATG	0.383													96	222					0	0	0	0	G	64153029	G	G	64153029	3	3	45	1	0	0	0	0	1	0	0	0	14284	507	18	4	209	4	SGPP1	14	64153029	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	18720903	64153029	43196511	133	9358											
C14orf102	55051	broad.mit.edu	37	chr14	90770702	90770702	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttcttagggttaatgccaagGcaggagtctcctttcctctt	7	15	9	10	0	3	0	0	0	3	0	5	1	4	1	3	3	1	2	3	3	3	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:90770702G>A	uc001xyi.1	-	5	613	c.582C>T	c.(580-582)TGC>TGT	p.C194C	C14orf102_uc010atp.1_5'UTR|C14orf102_uc001xyj.1_5'UTR	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	194	Potential.						protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		TAATGCCAAGGCAGGAGTCTC	0.418													23	136					0	0	0	0	A	90770702	A	A	90770702	2	1	45	1	0	0	0	0	0	0	0	1	1741	1195	42	4		4	C14orf102	14	90770702	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	26617673	90770702	16578838	134	9359											
HHIPL1	84439	broad.mit.edu	37	chr14	100119154	100119154	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtgagtggatccgcatcagCgagttcagagtctccgagga	10	8	14	9	3	3	2	2	1	1	1	5	6	4	4	2	2	1	2	2	2	0	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:100119154C>T	uc010avs.2	+	2	914	c.849C>T	c.(847-849)AGC>AGT	p.S283S	HHIPL1_uc001ygl.1_Silent_p.S283S	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	283					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				TCCGCATCAGCGAGTTCAGAG	0.617													18	53					0	0	0	0	T	100119154	T	T	100119154	2	4	45	1	0	0	0	0	0	0	0	1	7132	767	27	1		1	HHIPL1	14	100119154	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	9348452	100119154	7230386	135	9360											
DYNC1H1	1778	broad.mit.edu	37	chr14	102509076	102509076	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcagcattcccgtctcacgGatatgcaaggtaagtacctt	11	10	9	11	2	1	0	1	0	1	0	3	1	2	1	2	2	4	5	2	2	4	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:102509076G>A	uc001yks.2	+	69	12668	c.12504G>A	c.(12502-12504)CGG>CGA	p.R4168R		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4168	AAA 6 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CCGTCTCACGGATATGCAAGG	0.577													47	45					0	0	0	0	A	102509076	A	A	102509076	2	1	45	1	0	0	0	0	0	0	0	1	4863	1161	41	2		2	DYNC1H1	14	102509076	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	2389922	102509076	4840464	136	9361											
TJP1	7082	broad.mit.edu	37	chr15	30018667	30018667	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taccaaccatcattcattgaAtttaagttaattgtagctga	14	15	5	7	0	2	2	2	2	0	0	2	2	2	2	2	0	3	3	2	0	6	8			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr15:30018667A>G	uc001zcr.2	-	18	2803	c.2328T>C	c.(2326-2328)AAT>AAC	p.N776N	TJP1_uc010azl.2_Silent_p.N764N|TJP1_uc001zcq.2_Silent_p.N780N|TJP1_uc001zcs.2_Silent_p.N776N	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	776	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CATTCATTGAATTTAAGTTAA	0.373													33	88					0	0	0	0	G	30018667	G	G	30018667	2	3	45	1	0	0	0	0	0	0	0	1	15995	98	4	5		5	TJP1	15	30018667	Silent	SNP	A	TCGA-CN-4734-01A-01D-1434-08		30018667	72512725	137	9362											
SLC28A2	9153	broad.mit.edu	37	chr15	45564978	45564978	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgctgcagagggctctttCagaggtgagcaccaggaccc	8	8	14	11	0	2	3	1	1	1	2	2	4	2	4	2	3	3	4	2	3	0	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr15:45564978C>G	uc001zva.2	+	17	1920	c.1855C>G	c.(1855-1857)CAG>GAG	p.Q619E		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	619					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		AGGGCTCTTTCAGAGGTGAGC	0.522													22	51					0	0	0	0	G	45564978	G	G	45564978	3	3	45	1	0	0	0	0	1	0	0	0	14596	827	29	2	1917	2	SLC28A2	15	45564978	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	15546311	45564978	56966414	138	9363											
UNC13C	440279	broad.mit.edu	37	chr15	54305667	54305667	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaactgagaaaatggaaaaaGagtcaagaatgtgtctcctc	18	8	9	6	0	2	3	1	1	1	3	4	5	2	4	1	1	1	0	1	1	7	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr15:54305667G>C	uc002ack.2	+	1	567	c.567G>C	c.(565-567)AAG>AAC	p.K189N		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	189					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AATGGAAAAAGAGTCAAGAAT	0.458													30	90					0	0	0	0	C	54305667	C	C	54305667	3	2	45	1	0	0	0	0	1	0	0	0	17054	933	33	2	569	2	UNC13C	15	54305667	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	8740689	54305667	48225725	139	9364											
IDH3A	3419	broad.mit.edu	37	chr15	78454629	78454629	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaccgagggggcgagcaaGcgcattgctgagtttgcctt	8	9	14	10	3	1	1	1	1	0	0	1	3	1	1	2	2	4	4	2	2	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr15:78454629G>A	uc002bdd.2	+	6	558	c.531G>A	c.(529-531)AAG>AAA	p.K177K	IDH3A_uc010umt.1_Silent_p.K142K|IDH3A_uc010umu.1_Silent_p.K68K|IDH3A_uc002bde.2_Silent_p.K127K|IDH3A_uc010umv.1_Silent_p.K127K|IDH3A_uc002bdf.2_Silent_p.K28K|IDH3A_uc002bdg.2_Silent_p.K90K	NM_005530	NP_005521	P50213	IDH3A_HUMAN	isocitrate dehydrogenase 3 (NAD+) alpha	177					carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	GGGCGAGCAAGCGCATTGCTG	0.562													31	118					0	0	0	0	A	78454629	A	A	78454629	2	1	45	1	0	0	0	0	0	0	0	1	7535	962	34	4		4	IDH3A	15	78454629	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	24148962	78454629	24076763	140	9365											
KIF22	3835	broad.mit.edu	37	chr16	29811084	29811084	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaatcggccttttaccaatGagagcctgcagcctcatggt	9	11	9	12	1	2	1	2	1	0	1	3	2	2	1	4	2	4	1	4	2	3	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:29811084G>A	uc002dts.3	+	7	1150	c.1126G>A	c.(1126-1128)GAG>AAG	p.E376K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KIF22_uc010vdv.1_Missense_Mutation_p.E308K|KIF22_uc010vdw.1_Missense_Mutation_p.E308K|KIF22_uc010bzf.2_Missense_Mutation_p.E308K	NM_007317	NP_015556	Q14807	KIF22_HUMAN	kinesin family member 22	376					blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding				0						TTTTACCAATGAGAGCCTGCA	0.532													13	35					0	0	0	0	A	29811084	A	A	29811084	3	1	45	1	0	0	0	0	1	0	0	0	8329	1291	45	2	1152	2	KIF22	16	29811084	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08		29811084	60543669	141	9366											
ITGAD	3681	broad.mit.edu	37	chr16	31404708	31404708	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcggcactgtgcttcttctGagtggtaagtggggccaggg	5	12	16	8	1	2	1	0	1	2	0	3	1	2	1	1	5	1	3	1	5	1	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:31404708G>A	uc002ebv.1	+	1	76	c.27G>A	c.(25-27)CTG>CTA	p.L9L	ITGAD_uc010vfl.1_Silent_p.L9L|ITGAD_uc010cap.1_Silent_p.L9L	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	9					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TGCTTCTTCTGAGTGGTAAGT	0.627													62	159					0	0	0	0	A	31404708	A	A	31404708	2	1	45	1	0	0	0	0	0	0	0	1	7923	1277	45	2		2	ITGAD	16	31404708	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	1593624	31404708	58950045	142	9367											
PHKB	5257	broad.mit.edu	37	chr16	47694703	47694703	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaatggaaggacaaaccCacccacgaaattcttcaaaa	18	6	7	10	1	2	1	1	1	1	0	2	4	2	3	2	2	1	0	2	2	6	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:47694703C>G	uc002eev.3	+	22	2221	c.2169C>G	c.(2167-2169)CCC>CCG	p.P723P	PHKB_uc002eeu.3_Silent_p.P716P	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	723					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				AGGACAAACCCACCCACGAAA	0.488													28	137					0	0	0	0	G	47694703	G	G	47694703	2	3	45	1	0	0	0	0	0	0	0	1	11900	581	21	4		4	PHKB	16	47694703	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	16289995	47694703	42660050	143	9368											
NUP93	9688	broad.mit.edu	37	chr16	56878443	56878443	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caagcccgcactctgattacCtttgctggaatgataccata	11	11	7	12	1	1	2	0	2	1	0	1	3	1	3	3	1	4	2	3	1	5	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:56878443C>G	uc002eka.2	+	22	2503	c.2382C>G	c.(2380-2382)ACC>ACG	p.T794T	NUP93_uc002ekb.2_Silent_p.T671T|NUP93_uc010vhi.1_Silent_p.T671T	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	794					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						CTCTGATTACCTTTGCTGGAA	0.498													27	38					0	0	0	0	G	56878443	G	G	56878443	2	3	45	1	0	0	0	0	0	0	0	1	10826	668	24	4		4	NUP93	16	56878443	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	9183740	56878443	33476310	144	9369											
NFAT5	10725	broad.mit.edu	37	chr16	69681025	69681025	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atttattctacctcagtcacCgacagcaaggctatgcaagt	12	11	7	11	1	3	0	2	0	1	0	3	1	3	0	2	1	3	3	2	1	5	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:69681025C>T	uc002exm.1	+	3	1502	c.294C>T	c.(292-294)ACC>ACT	p.T98T	NFAT5_uc002exh.1_Missense_Mutation_p.P32L|NFAT5_uc002exi.2_Silent_p.T22T|NFAT5_uc002exj.1_Silent_p.T22T|NFAT5_uc002exk.1_Silent_p.T22T|NFAT5_uc002exl.1_Silent_p.T116T|NFAT5_uc002exn.1_Silent_p.T116T	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	98	Ser-rich.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CCTCAGTCACCGACAGCAAGG	0.532													96	302					0	0	0	0	T	69681025	T	T	69681025	2	4	45	1	0	0	0	0	0	0	0	1	10414	639	23	1		1	NFAT5	16	69681025	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	12802582	69681025	20673728	145	9370											
BCMO1	53630	broad.mit.edu	37	chr16	81295760	81295760	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagctttctcctacttgtctCacaccatccccgatttcacc	7	13	4	17	1	3	0	2	0	2	0	6	2	4	0	5	0	2	1	5	0	1	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:81295760C>G	uc002fgn.1	+	4	561	c.343C>G	c.(343-345)CAC>GAC	p.H115D	BCMO1_uc002fgm.1_Missense_Mutation_p.H115D|BCMO1_uc010vnp.1_Missense_Mutation_p.H46D	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	115					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						CTACTTGTCTCACACCATCCC	0.468													67	176					0	0	0	0	G	81295760	G	G	81295760	3	3	45	1	0	0	0	0	1	0	0	0	1386	826	29	2	357	2	BCMO1	16	81295760	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	11614735	81295760	9058993	146	9371											
OSGIN1	29948	broad.mit.edu	37	chr16	83983085	83983085	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaccgagaggctgctgcCggggaaatatgcagtgcaga	11	5	17	8	2	0	3	0	0	0	3	0	6	0	4	2	4	4	4	2	4	2	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:83983085C>T	uc002fha.2	+	1	414	c.31C>T	c.(31-33)CGG>TGG	p.R11W	OSGIN1_uc002fhb.2_5'UTR	NM_013370	NP_037502	Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	11					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity				0						AGGCTGCTGCCGGGGAAATAT	0.582													42	84					0	0	0	0	T	83983085	T	T	83983085	3	4	45	1	0	0	0	0	1	0	0	0	11343	643	23	1	33	1	OSGIN1	16	83983085	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	2687325	83983085	6371668	147	9372											
FBXO31	79791	broad.mit.edu	37	chr16	87367628	87367628	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctcgccaccatcctcacCaggtgtcccatctgggccct	6	8	9	18	1	2	0	1	0	1	0	5	0	4	0	6	3	0	1	6	3	0	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:87367628C>T	uc002fjw.2	-	8	1305	c.1261G>A	c.(1261-1263)GGT>AGT	p.G421S	FBXO31_uc010vot.1_Missense_Mutation_p.G249S|FBXO31_uc002fjv.2_Missense_Mutation_p.G313S	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	421					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		CCATCCTCACCAGGTGTCCCA	0.746													8	29					0	0	0	0	T	87367628	T	T	87367628	3	4	45	1	0	0	0	0	1	0	0	0	5773	594	21	4	366	4	FBXO31	16	87367628	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	3384543	87367628	2987125	148	9373											
RPA1	6117	broad.mit.edu	37	chr17	1747221	1747221	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttctgtcctagaacatccGtcccattactacggggaata	10	13	7	11	2	1	1	0	0	1	1	4	2	4	2	3	2	3	0	3	2	6	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:1747221G>A	uc002fto.2	+	3	207	c.92G>A	c.(91-93)CGT>CAT	p.R31H		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	31					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TAGAACATCCGTCCCATTACT	0.488								NER					24	105					0	0	0	0	A	1747221	A	A	1747221	3	1	45	1	0	0	0	0	1	0	0	0	13601	1145	40	1	102	1	RPA1	17	1747221	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08		1747221	79447989	149	9374											
ITGAE	3682	broad.mit.edu	37	chr17	3658514	3658514	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgtagagcaacgcccctccGgaccagtcaaaggccccgac	10	4	10	17	4	1	1	1	0	0	1	3	3	2	2	6	2	2	2	6	2	3	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:3658514G>T	uc002fwo.3	-	12	1380	c.1281C>A	c.(1279-1281)TCC>TCA	p.S427S		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	427	FG-GAP 3.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		ACGCCCCTCCGGACCAGTCAA	0.721													3	2					0.004672	0.004736	1	0	T	3658514	T	T	3658514	2	4	45	1	0	0	0	0	0	0	0	1	7924	1103	39	3		3	ITGAE	17	3658514	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	1911293	3658514	77536696	150	9375											
C17orf74	201243	broad.mit.edu	37	chr17	7329025	7329025	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccatggaaaaccagctatgGcataacaccgtgagatgttg	13	9	10	9	1	0	1	0	1	0	1	1	3	1	2	3	2	3	3	3	2	4	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:7329025G>A	uc002ggw.2	+	1	91	c.18G>A	c.(16-18)TGG>TGA	p.W6*	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	6						integral to membrane					0		Prostate(122;0.157)				ACCAGCTATGGCATAACACCG	0.592													65	170					0	0	0	0	A	7329025	A	A	7329025	4	1	45	1	0	0	0	0	0	1	0	0	1887	1212	42	4	20	4	C17orf74	17	7329025	Nonsense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	3670511	7329025	73866185	151	9376											
MYH13	8735	broad.mit.edu	37	chr17	10219279	10219279	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatcaactgtgtctgttgctCgtccttggctttgatttcac	5	17	9	10	1	3	1	2	1	1	0	5	2	4	1	1	1	2	3	1	1	1	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:10219279C>T	uc002gmk.1	-	28	3892	c.3802G>A	c.(3802-3804)GAG>AAG	p.E1268K		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1268	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GTCTGTTGCTCGTCCTTGGCT	0.463													48	156					0	0	0	0	T	10219279	T	T	10219279	3	4	45	1	0	0	0	0	1	0	0	0	10085	893	31	1	2070	1	MYH13	17	10219279	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	2890254	10219279	70975931	152	9377											
MYH13	8735	broad.mit.edu	37	chr17	10231210	10231210	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctgcaattggaggtcattCttctcctgcaggagggagac	9	10	12	10	0	3	1	1	0	2	1	4	4	3	3	2	4	2	2	2	4	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:10231210C>G	uc002gmk.1	-	22	2754	c.2664G>C	c.(2662-2664)AAG>AAC	p.K888N		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	888	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GGAGGTCATTCTTCTCCTGCA	0.527											OREG0024177	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	75					0	0	0	0	G	10231210	G	G	10231210	3	3	45	1	0	0	0	0	1	0	0	0	10085	912	32	2	3232	2	MYH13	17	10231210	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	11931	10231210	70964000	153	9378											
MYH13	8735	broad.mit.edu	37	chr17	10231229	10231229	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctcctgcaggagggagAccattttctcctccagctcc	6	12	8	15	0	3	1	0	0	3	1	7	3	5	2	5	2	2	2	5	2	0	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:10231229A>T	uc002gmk.1	-	22	2735	c.2645T>A	c.(2644-2646)GTC>GAC	p.V882D		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	882	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CAGGAGGGAGACCATTTTCTC	0.527											OREG0024177	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	74					0	0	0	0	T	10231229	T	T	10231229	3	4	45	1	0	0	0	0	1	0	0	0	10085	275	10	5	3251	5	MYH13	17	10231229	Missense_Mutation	SNP	A	TCGA-CN-4734-01A-01D-1434-08	19	10231229	70963981	154	9379											
MYO15A	51168	broad.mit.edu	37	chr17	18022599	18022599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtggacgcctggctgcagcGctcgagctcccgcatgggct	5	7	15	14	4	0	0	0	0	0	0	2	2	1	1	2	3	3	6	2	3	0	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:18022599G>A	uc010vxh.1	+	2	823	c.485G>A	c.(484-486)CGC>CAC	p.R162H		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	162	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGGCTGCAGCGCTCGAGCTCC	0.677													11	65					0	0	0	0	A	18022599	A	A	18022599	3	1	45	1	0	0	0	0	1	0	0	0	10116	1087	38	1	487	1	MYO15A	17	18022599	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	7791370	18022599	63172611	155	9380											
NOS2	4843	broad.mit.edu	37	chr17	26101285	26101285	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaggaaggcccctaacctGatagtagtagaaaggggaca	16	5	13	7	0	0	3	0	1	0	2	0	5	0	5	3	4	1	2	3	4	7	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:26101285G>T	uc002gzu.2	-	12	1738	c.1474C>A	c.(1474-1476)CAG>AAG	p.Q492K	NOS2_uc010crh.1_Missense_Mutation_p.Q492K|NOS2_uc010wab.1_Missense_Mutation_p.Q492K	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	492					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CCCCTAACCTGATAGTAGTAG	0.547													11	31					7.03913e-09	7.33655e-09	1	0	T	26101285	T	T	26101285	3	4	45	1	0	0	0	0	1	0	0	0	10597	1299	45	2	2051	2	NOS2	17	26101285	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	8078686	26101285	55093925	156	9381											
ABHD15	116236	broad.mit.edu	37	chr17	27889909	27889909	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggtccacacacggggtcGtcagcactgcagatacacag	10	5	14	12	2	1	1	1	0	0	1	3	1	2	1	1	4	3	2	1	4	1	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:27889909G>A	uc002hed.1	-	2	1141	c.1077C>T	c.(1075-1077)GAC>GAT	p.D359D		NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	359						extracellular region	carboxylesterase activity				0						ACACGGGGTCGTCAGCACTGC	0.602													12	101					0	0	0	0	A	27889909	A	A	27889909	2	1	45	1	0	0	0	0	0	0	0	1	81	1136	40	1		1	ABHD15	17	27889909	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	1788624	27889909	53305301	157	9382											
SSH2	85464	broad.mit.edu	37	chr17	27959836	27959836	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtctcctttcagttgaatCtgcccaactccttgactgat	8	15	6	12	0	3	3	1	3	2	0	5	3	4	3	3	0	2	1	3	0	2	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:27959836C>G	uc002heo.1	-	15	2295	c.2295G>C	c.(2293-2295)CAG>CAC	p.Q765H	SSH2_uc010wbh.1_Missense_Mutation_p.Q792H	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	765					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TCAGTTGAATCTGCCCAACTC	0.468													36	63					0	0	0	0	G	27959836	G	G	27959836	3	3	45	1	0	0	0	0	1	0	0	0	15251	912	32	2	1980	2	SSH2	17	27959836	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	69927	27959836	53235374	158	9383											
KRT12	3859	broad.mit.edu	37	chr17	39019389	39019389	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcacccttgggcctccccGtccagcaggcggcggtaggt	4	7	14	16	3	1	0	1	0	0	0	3	0	3	0	5	5	1	3	5	5	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:39019389G>A	uc002hvk.2	-	6	1326	c.1302C>T	c.(1300-1302)GAC>GAT	p.D434D		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	434	Rod.|Coil 2.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GGGCCTCCCCGTCCAGCAGGC	0.612													19	67					0	0	0	0	A	39019389	A	A	39019389	2	1	45	1	0	0	0	0	0	0	0	1	8488	1136	40	1		1	KRT12	17	39019389	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	11059553	39019389	42175821	159	9384											
CNTNAP1	8506	broad.mit.edu	37	chr17	40842782	40842782	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgagcgtggacagttgtgcgGcatgacaggctgtggacaac	9	7	16	9	3	0	1	0	1	0	0	0	4	0	3	0	4	3	3	0	4	1	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:40842782G>A	uc002iay.2	+	13	2097	c.1881G>A	c.(1879-1881)CGG>CGA	p.R627R	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	627	Extracellular (Potential).|Fibrinogen C-terminal.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		CAGTTGTGCGGCATGACAGGC	0.587													4	209					0	0	0	0	A	40842782	A	A	40842782	2	1	45	1	0	0	0	0	0	0	0	1	3661	1190	42	4		4	CNTNAP1	17	40842782	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	1823393	40842782	40352428	160	9385											
HOXB4	3214	broad.mit.edu	37	chr17	46654222	46654222	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggttctggaaccagatcttGatctggcgctcggagaggca	8	9	14	10	3	3	3	0	1	3	2	4	5	3	4	1	5	1	3	1	5	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:46654222G>C	uc002inp.2	-	2	680	c.618C>G	c.(616-618)ATC>ATG	p.I206M	HOXB3_uc010wlm.1_Intron|HOXB3_uc010dbf.2_Intron|HOXB3_uc010dbg.2_Intron|HOXB3_uc002ino.2_5'Flank|HOXB3_uc010wlk.1_5'Flank|HOXB3_uc010wll.1_Intron	NM_024015	NP_076920	P17483	HXB4_HUMAN	homeobox B4	206	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACCAGATCTTGATCTGGCGCT	0.607													62	215					0	0	0	0	C	46654222	C	C	46654222	3	2	45	1	0	0	0	0	1	0	0	0	7342	1280	45	2	141	2	HOXB4	17	46654222	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	5811440	46654222	34540988	161	9386											
CARD14	79092	broad.mit.edu	37	chr17	78182030	78182030	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaccgggcgccctgtctataCagcagcctggctcctgacgg	6	7	13	15	3	1	1	0	1	1	0	2	2	2	1	4	3	3	2	4	3	2	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:78182030C>T	uc002jxw.1	+	21	3096	c.2901C>T	c.(2899-2901)TAC>TAT	p.Y967Y	CARD14_uc002jxt.1_RNA	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	967	Guanylate kinase-like.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CCTGTCTATACAGCAGCCTGG	0.672													2	2					0	0	0	0	T	78182030	T	T	78182030	2	4	45	1	0	0	0	0	0	0	0	1	2658	489	17	4		4	CARD14	17	78182030	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	31527808	78182030	3013180	162	9387											
ZNF521	25925	broad.mit.edu	37	chr18	22805215	22805215	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtaggctgccccacaaatGtcgcagccgtacataggctc	9	8	11	13	2	0	0	0	0	0	0	2	0	0	0	3	2	3	5	3	2	4	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr18:22805215G>A	uc002kvk.2	-	4	2914	c.2667C>T	c.(2665-2667)GAC>GAT	p.D889D	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.D889D|ZNF521_uc002kvl.2_Silent_p.D669D	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	889	C2H2-type 21; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CCCCACAAATGTCGCAGCCGT	0.522			T	PAX5	ALL								27	67					0	0	0	0	A	22805215	A	A	22805215	2	1	45	1	0	0	0	0	0	0	0	1	18032	1368	48	4		4	ZNF521	18	22805215	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08		22805215	55272033	163	9388											
ASXL3	80816	broad.mit.edu	37	chr18	31319619	31319619	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagtttgccacttccttcaGaaacatctccaatttccaac	11	12	3	15	0	2	1	1	0	1	1	5	1	4	1	5	0	3	1	5	0	3	4			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr18:31319619G>C	uc010dmg.1	+	11	2306	c.2251G>C	c.(2251-2253)GAA>CAA	p.E751Q	ASXL3_uc002kxq.2_Missense_Mutation_p.E458Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	751	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ACTTCCTTCAGAAACATCTCC	0.433													82	230					0	0	0	0	C	31319619	C	C	31319619	3	2	45	1	0	0	0	0	1	0	0	0	1070	943	33	2	2293	2	ASXL3	18	31319619	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	8514404	31319619	46757629	164	9389											
KIAA1468	57614	broad.mit.edu	37	chr18	59888730	59888730	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagatgaaaacgatgatcaGgtaaagttactttttgtttt	13	16	8	4	1	2	3	2	2	0	1	2	4	2	3	0	1	2	3	0	1	5	6			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr18:59888730G>A	uc002lil.2	+	5	1073	c.858G>A	c.(856-858)CAG>CAA	p.Q286Q	KIAA1468_uc002lik.1_Silent_p.Q286Q|KIAA1468_uc010xel.1_Silent_p.Q286Q|KIAA1468_uc002lim.2_5'UTR	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	286	LisH.						binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				ACGATGATCAGGTAAAGTTAC	0.234													14	51					0	0	0	0	A	59888730	A	A	59888730	2	1	45	1	0	0	0	0	0	0	0	1	8275	1014	35	4		4	KIAA1468	18	59888730	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	28569111	59888730	18188518	165	9390											
SALL3	27164	broad.mit.edu	37	chr18	76754267	76754267	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtcctgcagcagcacatccGcatgcacatgggcggccaga	9	5	13	14	2	0	1	0	0	0	1	2	1	2	1	3	3	4	5	3	3	0	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr18:76754267G>A	uc002lmt.2	+	2	2276	c.2276G>A	c.(2275-2277)CGC>CAC	p.R759H	SALL3_uc010dra.2_Missense_Mutation_p.R366H	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	759	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CAGCACATCCGCATGCACATG	0.657													13	45					0	0	0	0	A	76754267	A	A	76754267	3	1	45	1	0	0	0	0	1	0	0	0	13877	1087	38	1	2282	1	SALL3	18	76754267	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	16865537	76754267	1322981	166	9391											
CRB3	92359	broad.mit.edu	37	chr19	6466612	6466612	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacctaccggcccagtagcGaggagcaggtgggtgcccgc	7	4	16	14	3	0	0	0	0	0	0	0	2	0	1	4	4	4	3	4	4	2	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:6466612G>A	uc002mey.2	+	4	823	c.292G>A	c.(292-294)GAG>AAG	p.E98K	CRB3_uc002mez.2_Missense_Mutation_p.E98K|CRB3_uc002mfa.2_Missense_Mutation_p.E98K	NM_139161	NP_631900	Q9BUF7	CRUM3_HUMAN	crumbs 3 isoform a precursor	98	Cytoplasmic (Potential).				protein localization in plasma membrane|tight junction assembly	apical plasma membrane|integral to membrane|tight junction	SH3 domain binding				0						GCCCAGTAGCGAGGAGCAGGT	0.677													21	80					0	0	0	0	A	6466612	A	A	6466612	3	1	45	1	0	0	0	0	1	0	0	0	3865	1059	37	1	302	1	CRB3	19	6466612	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08		6466612	52662371	167	9392											
OR7G1	125962	broad.mit.edu	37	chr19	9226035	9226035	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccagaaatggacattcatGaggactgtgtacctcagtgg	11	9	11	10	0	2	2	2	1	0	1	2	4	2	4	3	3	1	1	3	3	2	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:9226035G>A	uc002mks.1	-	1	405	c.405C>T	c.(403-405)CTC>CTT	p.L135L		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	135	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						GGACATTCATGAGGACTGTGT	0.493													28	98					0	0	0	0	A	9226035	A	A	9226035	2	1	45	1	0	0	0	0	0	0	0	1	11276	1277	45	2		2	OR7G1	19	9226035	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	2759423	9226035	49902948	168	9393											
OR10H1	26539	broad.mit.edu	37	chr19	15918182	15918182	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcttcaagatggcggccacGatgaaggcataggagaggag	13	6	15	7	2	2	3	1	1	1	2	2	6	2	4	1	5	0	1	1	5	3	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:15918182G>A	uc002nbq.2	-	1	755	c.666C>T	c.(664-666)ATC>ATT	p.I222I		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGGCGGCCACGATGAAGGCAT	0.577													18	101					0	0	0	0	A	15918182	A	A	15918182	2	1	45	1	0	0	0	0	0	0	0	1	10959	1048	37	1		1	OR10H1	19	15918182	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	6692147	15918182	43210801	169	9394											
MAST3	23031	broad.mit.edu	37	chr19	18254654	18254654	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcccagcccatctctcctGaataccatcagcctggacac	9	8	7	17	0	2	1	1	1	1	0	5	2	4	2	5	2	3	0	5	2	2	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:18254654G>A	uc002nhz.3	+	21	2334	c.2334G>A	c.(2332-2334)CTG>CTA	p.L778L		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	778							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						CATCTCTCCTGAATACCATCA	0.607													10	26					0	0	0	0	A	18254654	A	A	18254654	2	1	45	1	0	0	0	0	0	0	0	1	9379	1277	45	2		2	MAST3	19	18254654	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	2336472	18254654	40874329	170	9395											
TMEM161A	54929	broad.mit.edu	37	chr19	19230817	19230817	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggcagccgtccaccagatGaggtaggccaggacgccacg	10	3	14	14	3	0	2	0	1	0	1	1	3	1	3	5	4	1	2	5	4	1	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:19230817G>A	uc002nlg.2	-	12	1392	c.1362C>T	c.(1360-1362)CTC>CTT	p.L454L	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Silent_p.L429L|TMEM161A_uc002nli.2_Silent_p.L351L|TMEM161A_uc002nlj.2_Silent_p.L329L	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	454	Helical; (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			TCCACCAGATGAGGTAGGCCA	0.662													4	7					0	0	0	0	A	19230817	A	A	19230817	2	1	45	1	0	0	0	0	0	0	0	1	16142	1277	45	2		2	TMEM161A	19	19230817	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	976163	19230817	39898166	171	9396											
FCGBP	8857	broad.mit.edu	37	chr19	40392591	40392591	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggggatacagccctcgctcCccggcgggcaggtgggcggc	4	5	18	14	4	0	0	0	0	0	0	2	1	1	1	3	7	2	2	3	7	1	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:40392591C>T	uc002omp.3	-	16	7921	c.7913G>A	c.(7912-7914)GGG>GAG	p.G2638E		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	2638	VWFD 6.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCCTCGCTCCCCGGCGGGCA	0.667													19	66					0	0	0	0	T	40392591	T	T	40392591	3	4	45	1	0	0	0	0	1	0	0	0	5810	623	22	4	8388	4	FCGBP	19	40392591	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	21161774	40392591	18736392	172	9397											
PSG6	5675	broad.mit.edu	37	chr19	43530465	43530465	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagttctctcctcacctgtGagcaggagccccttccattt	7	12	8	14	0	2	1	1	1	1	0	5	3	4	2	5	1	2	2	5	1	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:43530465G>C	uc002ovh.1	-	1	167	c.78C>G	c.(76-78)CTC>CTG	p.L26L	PSG11_uc002ouw.2_Silent_p.L26L|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Silent_p.L26L|PSG11_uc002ovm.1_Silent_p.L20L|PSG11_uc002ovn.1_Silent_p.L26L|PSG11_uc002ovo.1_Silent_p.L20L|PSG11_uc002ovp.1_Silent_p.L20L			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	20					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				CCTCACCTGTGAGCAGGAGCC	0.562													46	204					0	0	0	0	C	43530465	C	C	43530465	2	2	45	1	0	0	0	0	0	0	0	1	12721	1277	45	2		2	PSG6	19	43530465	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	3137874	43530465	15598518	173	9398											
ZNF283	284349	broad.mit.edu	37	chr19	44341279	44341279	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgcctggaccctgctcagagGgacttgtacgtggatgtaat	8	11	13	9	1	1	1	1	0	0	1	1	4	1	4	2	3	3	3	2	3	2	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:44341279G>A	uc002oxr.3	+	6	553	c.285G>A	c.(283-285)AGG>AGA	p.R95R	ZNF283_uc002oxp.3_Intron	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	95	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CTGCTCAGAGGGACTTGTACG	0.463													39	86					0	0	0	0	A	44341279	A	A	44341279	2	1	45	1	0	0	0	0	0	0	0	1	17887	1223	43	4		4	ZNF283	19	44341279	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08	810814	44341279	14787704	174	9399											
PPP5C	5536	broad.mit.edu	37	chr19	46891915	46891915	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actatatcatccgcagccacGaagtcaaggccgagggctac	12	6	10	13	3	2	0	2	0	0	0	3	2	3	0	3	2	2	2	3	2	5	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:46891915G>A	uc002pem.2	+	11	1342	c.1282G>A	c.(1282-1284)GAA>AAA	p.E428K	PPP5C_uc010xya.1_Missense_Mutation_p.E295K|PPP5C_uc002pen.2_Missense_Mutation_p.E406K	NM_006247	NP_006238	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	428	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		CCGCAGCCACGAAGTCAAGGC	0.597													48	160					0	0	0	0	A	46891915	A	A	46891915	3	1	45	1	0	0	0	0	1	0	0	0	12466	1059	37	1	1324	1	PPP5C	19	46891915	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	2550636	46891915	12237068	175	9400											
PLEKHA4	57664	broad.mit.edu	37	chr19	49368815	49368815	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggttgggatccctcctgagcGcattgcctctcttcccaaag	6	11	10	14	1	1	1	0	1	1	0	5	2	4	2	4	2	2	2	4	2	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:49368815G>A	uc002pkx.2	-	3	688	c.137C>T	c.(136-138)GCG>GTG	p.A46V	PLEKHA4_uc010eml.2_Missense_Mutation_p.A46V	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	46						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		CCTCCTGAGCGCATTGCCTCT	0.572													14	53					0	0	0	0	A	49368815	A	A	49368815	3	1	45	1	0	0	0	0	1	0	0	0	12113	1087	38	1	2274	1	PLEKHA4	19	49368815	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	2476900	49368815	9760168	176	9401											
LILRA4	23547	broad.mit.edu	37	chr19	54849916	54849916	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgccaggtgatcacgggacCtggctcggcccacaggatgg	8	6	15	12	2	1	1	1	1	0	0	2	3	1	3	3	6	1	1	3	6	0	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:54849916C>T	uc002qfj.2	-	3	163	c.106G>A	c.(106-108)GGT>AGT	p.G36S	LILRA4_uc002qfi.2_5'UTR	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	36	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		ATCACGGGACCTGGCTCGGCC	0.572											OREG0003656	type=REGULATORY REGION|Gene=LILRA4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	37	93					0	0	0	0	T	54849916	T	T	54849916	3	4	45	1	0	0	0	0	1	0	0	0	8828	681	24	4	1417	4	LILRA4	19	54849916	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	5481101	54849916	4279067	177	9402											
SLC23A2	9962	broad.mit.edu	37	chr20	4850573	4850573	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtttattgcgtggatggggGggggtggggcacaggacagc	6	9	21	5	1	0	0	0	0	0	0	0	2	0	2	0	8	2	2	0	8	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr20:4850573G>T	uc002wlg.1	-	12	1604	c.1229C>A	c.(1228-1230)CCC>CAC	p.P410H	SLC23A2_uc010zqr.1_Missense_Mutation_p.P295H|SLC23A2_uc002wlh.1_Missense_Mutation_p.P410H|SLC23A2_uc002wli.2_Missense_Mutation_p.P409H	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	410					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						GTGGATGGGGGGGGGTGGGGC	0.542													36	75					6.90743e-12	7.40796e-12	1	0	T	4850573	T	T	4850573	3	4	45	1	0	0	0	0	1	0	0	0	14527	1232	43	4	747	4	SLC23A2	20	4850573	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08		4850573	58174947	178	9403											
C20orf71	128861	broad.mit.edu	37	chr20	31812910	31812910	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctctcatctgcaggtccttCgataacaacatcgtaaagat	12	12	6	11	2	3	1	1	0	2	1	7	2	4	1	1	1	3	2	1	1	4	3	rs140343618	byFrequency	TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr20:31812910C>T	uc002wyr.2	+	4	601	c.393C>T	c.(391-393)TTC>TTT	p.F131F	C20orf71_uc002wys.2_Silent_p.F95F	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium	131						extracellular region	lipid binding			ovary(1)|skin(1)	2						GCAGGTCCTTCGATAACAACA	0.383													28	92					0	0	0	0	T	31812910	T	T	31812910	2	4	45	1	0	0	0	0	0	0	0	1	2127	883	31	1		1	C20orf71	20	31812910	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	26962337	31812910	31212610	179	9404											
C20orf165	128497	broad.mit.edu	37	chr20	44515723	44515723	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcctgttccaccagaggcCaccaccactggctctacagg	8	6	11	16	0	1	1	0	0	1	1	2	1	2	1	6	4	1	2	6	4	1	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr20:44515723C>T	uc002xqf.2	-	2	126	c.117G>A	c.(115-117)GTG>GTA	p.V39V		NM_080608	NP_542175	Q9BR10	CT165_HUMAN	chromosome 20 open reading frame 165	39						integral to membrane					0		Myeloproliferative disorder(115;0.0122)				CACCAGAGGCCACCACCACTG	0.607													36	102					0	0	0	0	T	44515723	T	T	44515723	2	4	45	1	0	0	0	0	0	0	0	1	2104	581	21	4		4	C20orf165	20	44515723	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	12702813	44515723	18509797	180	9405											
TPTE	7179	broad.mit.edu	37	chr21	10951321	10951321	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaaataaggcaatagctaGagaaatagaacgatactcca	22	6	7	6	1	0	2	0	0	0	2	1	4	1	2	1	1	3	2	1	1	11	5			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr21:10951321G>A	uc002yip.1	-	10	759	c.391C>T	c.(391-393)CTA>TTA	p.L131L	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.L113L|TPTE_uc002yir.1_Silent_p.L93L|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	131	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCAATAGCTAGAGAAATAGAA	0.343													24	80					0	0	0	0	A	10951321	A	A	10951321	2	1	45	1	0	0	0	0	0	0	0	1	16497	933	33	2		2	TPTE	21	10951321	Silent	SNP	G	TCGA-CN-4734-01A-01D-1434-08		10951321	37178574	181	9406											
CBR3	874	broad.mit.edu	37	chr21	37507579	37507579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgaactgtgccgacagttctCtggggatgtggtgctcaccg	6	10	14	11	3	2	0	1	0	1	0	3	3	2	1	2	3	3	2	2	3	1	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr21:37507579C>T	uc002yve.2	+	1	317	c.89C>T	c.(88-90)TCT>TTT	p.S30F	uc002yvc.1_Intron|uc002yvd.1_Intron	NM_001236	NP_001227	O75828	CBR3_HUMAN	carbonyl reductase 3	30	NADP.					cytosol|nucleus	carbonyl reductase (NADPH) activity|NADPH binding				0						CGACAGTTCTCTGGGGATGTG	0.726													3	13					0	0	0	0	T	37507579	T	T	37507579	3	4	45	1	0	0	0	0	1	0	0	0	2721	913	32	2	91	2	CBR3	21	37507579	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	26556258	37507579	10622316	182	9407											
PCBP3	54039	broad.mit.edu	37	chr21	47350746	47350746	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagaagctcaaaatctgatGggccagtcatcaggtaacac	15	7	10	9	0	4	2	3	1	1	1	4	3	4	2	1	2	2	2	1	2	5	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr21:47350746G>C	uc002zhq.1	+	11	968	c.843G>C	c.(841-843)ATG>ATC	p.M281I	PCBP3_uc010gqb.2_Missense_Mutation_p.M281I|PCBP3_uc002zhp.1_Intron|PCBP3_uc002zhs.1_Missense_Mutation_p.M255I|PCBP3_uc002zhr.1_Missense_Mutation_p.M280I|PCBP3_uc002zht.1_Missense_Mutation_p.M271I	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	281					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		aaaatctgatgggccagtcat	0.279													17	38					0	0	0	0	C	47350746	C	C	47350746	3	2	45	1	0	0	0	0	1	0	0	0	11556	1348	47	4	885	4	PCBP3	21	47350746	Missense_Mutation	SNP	G	TCGA-CN-4734-01A-01D-1434-08	9843167	47350746	779149	183	9408											
DIP2A	23181	broad.mit.edu	37	chr21	47969758	47969758	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgagcagcggccggatgcctCggaggaggacagcttccagt	8	6	16	11	3	0	1	0	1	0	0	2	5	1	5	3	5	4	2	3	5	0	1			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr21:47969758C>T	uc002zjo.2	+	22	2780	c.2597C>T	c.(2596-2598)TCG>TTG	p.S866L	DIP2A_uc011afy.1_Missense_Mutation_p.S802L|DIP2A_uc011afz.1_Missense_Mutation_p.S862L|DIP2A_uc002zjn.2_Missense_Mutation_p.S866L	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	866					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CCGGATGCCTCGGAGGAGGAC	0.642													37	118					0	0	0	0	T	47969758	T	T	47969758	3	4	45	1	0	0	0	0	1	0	0	0	4549	893	31	1	2732	1	DIP2A	21	47969758	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	619012	47969758	160137	184	9409											
SEC14L2	23541	broad.mit.edu	37	chr22	30812008	30812008	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaacagcagtatgaacacagCgtgcagatttcccgtggctc	12	8	10	11	2	0	2	0	1	0	1	2	2	1	2	1	1	5	4	1	1	3	2			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr22:30812008C>T	uc003ahr.2	+	10	1016	c.843C>T	c.(841-843)AGC>AGT	p.S281S	SEC14L2_uc003ahq.2_Silent_p.S281S|SEC14L2_uc011akx.1_Silent_p.S227S|SEC14L2_uc003ahs.2_Silent_p.S207S|SEC14L2_uc011aky.1_Silent_p.S198S|SEC14L2_uc003aht.2_RNA|SEC14L2_uc003ahu.3_Silent_p.S105S|SEC14L2_uc010gvv.2_RNA|SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Intron|MTP18_uc003ahv.1_Silent_p.S105S|MTP18_uc010gvy.1_Intron	NM_012429	NP_036561	O76054	S14L2_HUMAN	SEC14-like 2 isoform 1	281	GOLD.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	phospholipid binding|transporter activity|vitamin E binding				0					Vitamin E(DB00163)	ATGAACACAGCGTGCAGATTT	0.557													30	110					0	0	0	0	T	30812008	T	T	30812008	2	4	45	1	0	0	0	0	0	0	0	1	14047	767	27	1		1	SEC14L2	22	30812008	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08		30812008	20492558	185	9410											
CACNG2	10369	broad.mit.edu	37	chr22	36960638	36960638	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctggagtgtgagggctcCgtggagcgcgagctggagcg	5	7	19	10	4	0	1	0	1	0	0	2	5	2	4	2	4	3	2	2	4	0	0			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr22:36960638C>A	uc003aps.1	-	4	1014	c.732G>T	c.(730-732)ACG>ACT	p.T244T		NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	244					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						GTGAGGGCTCCGTGGAGCGCG	0.697													35	101					9.84934e-19	1.07712e-18	1	0	A	36960638	A	A	36960638	2	1	45	1	0	0	0	0	0	0	0	1	2569	639	23	3		3	CACNG2	22	36960638	Silent	SNP	C	TCGA-CN-4734-01A-01D-1434-08	6148630	36960638	14343928	186	9411											
CNKSR2	22866	broad.mit.edu	37	chrX	21627677	21627678	+	In_Frame_Ins	INS	-	GAG	GAG																															aacccccagaggtggaggaaINSgaggaggaggaggaggagga																										TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chrX:21627677_21627678insGAG	uc004czx.1	+	20	2670_2671	c.2634_2635insGAG	c.(2632-2637)insGAG	p.886_887insE	CNKSR2_uc004czw.2_In_Frame_Ins_p.886_887insE|CNKSR2_uc011mjn.1_In_Frame_Ins_p.837_838insE|CNKSR2_uc011mjo.1_In_Frame_Ins_p.856_857insE|CNKSR2_uc004czy.2_In_Frame_Ins_p.478_479insE	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	886_887	Potential.|Poly-Glu.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						aggtggaggaagaggaggagga	0.376													---	---	---								GAG	21627678	GAG	GAG	21627677	7	5	45	1	0	1	1	0	0	0	0	0	3622	69	3	0	2712	0	CNKSR2	23	21627677	In_Frame_Ins	INS	-	TCGA-CN-4734-01A-01D-1434-08		21627677	133642883	187	9412											
BCOR	54880	broad.mit.edu	37	chrX	39930340	39930340	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggctgaatttgcacatctCggagtctttggttgctgggt	5	15	14	7	1	2	1	0	1	2	0	3	2	2	2	0	4	2	4	0	4	1	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chrX:39930340C>T	uc004den.3	-	6	3416	c.3124G>A	c.(3124-3126)GAG>AAG	p.E1042K	BCOR_uc004dep.3_Missense_Mutation_p.E1042K|BCOR_uc004deo.3_Missense_Mutation_p.E1024K|BCOR_uc004dem.3_Missense_Mutation_p.E1042K	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1042					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TTGCACATCTCGGAGTCTTTG	0.488													34	28					0	0	0	0	T	39930340	T	T	39930340	3	4	45	1	0	0	0	0	1	0	0	0	1388	893	31	1	2183	1	BCOR	23	39930340	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	18302663	39930340	115340220	188	9413											
KLHL13	90293	broad.mit.edu	37	chrX	117033238	117033238	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caatgacatagagcctttctCccactgtacacatgcaatgc	12	10	6	13	0	1	2	0	1	1	1	2	2	1	2	2	0	4	2	2	0	4	3			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chrX:117033238C>A	uc004eql.2	-	7	1663	c.1601G>T	c.(1600-1602)GGA>GTA	p.G534V	KLHL13_uc004eqk.2_Missense_Mutation_p.G483V|KLHL13_uc011mtn.1_Missense_Mutation_p.G374V|KLHL13_uc011mto.1_Missense_Mutation_p.G528V|KLHL13_uc011mtp.1_Missense_Mutation_p.G536V|KLHL13_uc004eqm.2_Missense_Mutation_p.G483V|KLHL13_uc011mtq.1_Missense_Mutation_p.G518V	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	534	Kelch 4.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						GAGCCTTTCTCCCACTGTACA	0.458													175	184					1.12187e-70	1.27069e-70	1	0	A	117033238	A	A	117033238	3	1	45	1	0	0	0	0	1	0	0	0	8408	855	30	2	370	2	KLHL13	23	117033238	Missense_Mutation	SNP	C	TCGA-CN-4734-01A-01D-1434-08	77102898	117033238	38237322	189	9414											
RERE	473	broad.mit.edu	37	chr1	8421855	8421855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcttggagctggtcctgtCagcctcctccgtatcagagg	5	12	11	13	1	3	1	2	0	1	1	6	2	6	2	4	3	2	2	4	3	1	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:8421855C>T	uc001ape.2	-	18	2794	c.1984G>A	c.(1984-1986)GAC>AAC	p.D662N	RERE_uc001apf.2_Missense_Mutation_p.D662N|RERE_uc010nzx.1_Missense_Mutation_p.D394N|RERE_uc001apd.2_Missense_Mutation_p.D108N	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	662					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CTGGTCCTGTCAGCCTCCTCC	0.552													47	107					0	0	0	0	T	8421855	T	T	8421855	3	4	46	1	0	0	0	0	1	0	0	0	13296	826	29	2	2744	2	RERE	1	8421855	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08		8421855	240828766	1	9415											
SLC2A5	6518	broad.mit.edu	37	chr1	9101976	9101976	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagctcccctaagtacatggGgaccacgttggaagatacac	12	7	10	12	1	0	1	0	0	0	1	1	3	1	3	3	3	3	3	3	3	4	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:9101976G>C	uc001apo.2	-	5	731	c.439C>G	c.(439-441)CCC>GCC	p.P147A	SLC2A5_uc010nzy.1_Missense_Mutation_p.P88A|SLC2A5_uc010nzz.1_Missense_Mutation_p.P32A|SLC2A5_uc010oaa.1_Missense_Mutation_p.P103A|SLC2A5_uc010oab.1_Missense_Mutation_p.P147A|SLC2A5_uc010oac.1_Missense_Mutation_p.P105R|SLC2A5_uc001app.3_Missense_Mutation_p.P147A	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	147	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AAGTACATGGGGACCACGTTG	0.512													12	39					0	0	0	0	C	9101976	C	C	9101976	3	2	46	1	0	0	0	0	1	0	0	0	14612	1232	43	4	1262	4	SLC2A5	1	9101976	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	680121	9101976	240148645	2	9416											
NBPF3	84224	broad.mit.edu	37	chr1	21808093	21808093	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttctacttttccaggctCagcagagagctgccggaggt	7	13	11	10	1	2	1	1	0	1	1	3	3	3	2	2	3	4	3	2	3	1	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:21808093C>A	uc001ber.2	+	13	1787	c.1437C>A	c.(1435-1437)CTC>CTA	p.L479L	NBPF3_uc001bes.2_Silent_p.L423L|NBPF3_uc009vqb.2_Silent_p.L467L|NBPF3_uc010odm.1_Silent_p.L409L	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	479	NBPF 4.					cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TTTCCAGGCTCAGCAGAGAGC	0.458													44	106					1.02591e-13	1.12099e-13	1	0	A	21808093	A	A	21808093	2	1	46	1	0	0	0	0	0	0	0	1	10251	813	29	2		2	NBPF3	1	21808093	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	12706117	21808093	227442528	3	9417											
CELA3B	23436	broad.mit.edu	37	chr1	22313044	22313044	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgactctggaggacccctCaactgccccacagaggatgg	9	6	13	13	0	2	2	1	1	1	1	2	5	2	5	4	5	2	0	4	5	1	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:22313044C>T	uc001bfk.2	+	7	778	c.663C>T	c.(661-663)CTC>CTT	p.L221L	CELA3B_uc009vqf.2_Intron	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	221	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						GAGGACCCCTCAACTGCCCCA	0.572													7	96					0	0	0	0	T	22313044	T	T	22313044	2	4	46	1	0	0	0	0	0	0	0	1	3229	813	29	2		2	CELA3B	1	22313044	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	504951	22313044	226937577	4	9418											
ZNF436	80818	broad.mit.edu	37	chr1	23688794	23688795	+	Missense_Mutation	DNP	GC	AA	AA																															acaagcattgcattcatatgGcttctctccagtgtgagttc																										TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:23688794_23688795GC>AA	uc001bgt.2	-	3	1461_1462	c.1080_1081GC>TT	c.(1078-1083)AAGCCA>AATTCA	p.360_361KP>NS	ZNF436_uc001bgu.2_Missense_Mutation_p.360_361KP>NS	NM_030634	NP_085137	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	360_361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		CATTCATATGGCTTCTCTCCAG	0.48													121	154					0	0	0	0	AA	23688795	AA	AA	23688794	3	1	46	1	0	0	0	0	1	0	0	0	17976	1203	42	4	335	4	ZNF436	1	23688794	Missense_Mutation	DNP	GC	TCGA-CN-4735-01A-01D-1434-08	1375750	23688794	225561827	5	9419											
NIPAL3	57185	broad.mit.edu	37	chr1	24766687	24766687	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgattggcgccctcttggCgatcttcgggcacctcgtgg	3	11	13	14	4	2	1	0	1	2	0	4	2	2	1	3	4	0	1	3	4	0	3	rs143586098		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:24766687C>T	uc001bjh.2	+	3	526	c.119C>T	c.(118-120)GCG>GTG	p.A40V	NIPAL3_uc010oek.1_Missense_Mutation_p.A40V|NIPAL3_uc001bjg.2_Missense_Mutation_p.A40V|NIPAL3_uc009vrc.2_5'UTR	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	40	Helical; (Potential).					integral to membrane					0						GCCCTCTTGGCGATCTTCGGG	0.537													41	108					0	0	0	0	T	24766687	T	T	24766687	3	4	46	1	0	0	0	0	1	0	0	0	10480	768	27	1	125	1	NIPAL3	1	24766687	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	1077893	24766687	224483934	6	9420											
PPIE	10450	broad.mit.edu	37	chr1	40214724	40214724	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatctatgggaagaagttcGatgatgaaaactttatcctc	13	12	8	8	1	1	3	0	2	1	1	4	5	2	4	2	1	1	1	2	1	6	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:40214724G>A	uc001cds.1	+	8	701	c.658G>A	c.(658-660)GAT>AAT	p.D220N	PPIE_uc001cdt.1_Missense_Mutation_p.D154N|PPIE_uc010oiy.1_Missense_Mutation_p.D141N|PPIE_uc001cdu.1_RNA|PPIE_uc001cdv.2_Missense_Mutation_p.D220N|PPIE_uc001cdw.2_Missense_Mutation_p.D220N|PPIE_uc001cdx.1_Missense_Mutation_p.D136N	NM_006112	NP_006103	Q9UNP9	PPIE_HUMAN	peptidylprolyl isomerase E isoform 1	220	PPIase cyclophilin-type.				protein folding|regulation of transcription, DNA-dependent	catalytic step 2 spliceosome	cyclosporin A binding|nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|RNA binding				0	all_cancers(7;1.63e-13)|all_lung(5;2.27e-16)|all_epithelial(6;1.35e-15)|Lung NSC(20;1.49e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;2.7e-17)|all cancers(16;5.5e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAAGAAGTTCGATGATGAAAA	0.552													51	94					0	0	0	0	A	40214724	A	A	40214724	3	1	46	1	0	0	0	0	1	0	0	0	12382	1058	37	1	688	1	PPIE	1	40214724	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	15448037	40214724	209035897	7	9421											
PTPRF	5792	broad.mit.edu	37	chr1	44069435	44069435	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcccaacaccatagatttcgGcaaggatgaccagcacttca	13	7	8	13	1	1	2	1	1	0	1	2	3	1	3	3	2	2	2	3	2	3	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:44069435G>A	uc001cjr.2	+	16	2952	c.2612G>A	c.(2611-2613)GGC>GAC	p.G871D	PTPRF_uc001cjs.2_Missense_Mutation_p.G862D|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Missense_Mutation_p.G431D|PTPRF_uc001cjv.2_Missense_Mutation_p.G331D|PTPRF_uc001cjw.2_Missense_Mutation_p.G97D	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	871	Extracellular (Potential).|Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATAGATTTCGGCAAGGATGAC	0.637													35	85					0	0	0	0	A	44069435	A	A	44069435	3	1	46	1	0	0	0	0	1	0	0	0	12866	1203	42	4	2666	4	PTPRF	1	44069435	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	3854711	44069435	205181186	8	9422											
MAST2	23139	broad.mit.edu	37	chr1	46500768	46500768	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgcagcctgctccctcacGggccctaggcaccctccggc	4	6	11	20	2	1	0	1	0	0	0	3	0	3	0	5	3	3	4	5	3	1	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:46500768G>T	uc001cov.2	+	29	4710	c.4427G>T	c.(4426-4428)CGG>CTG	p.R1476L	MAST2_uc001cow.2_Missense_Mutation_p.R1475L|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	1476					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GCTCCCTCACGGGCCCTAGGC	0.662													21	40					5.26018e-13	5.66481e-13	1	0	T	46500768	T	T	46500768	3	4	46	1	0	0	0	0	1	0	0	0	9378	1116	39	3	4541	3	MAST2	1	46500768	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	2431333	46500768	202749853	9	9423											
MYSM1	114803	broad.mit.edu	37	chr1	59147716	59147716	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaggcaactgcctggcatCaactattattccccttccat	11	11	6	13	0	1	1	1	0	0	1	3	1	3	1	4	2	3	2	4	2	5	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:59147716C>T	uc009wab.1	-	8	1023	c.1000G>A	c.(1000-1002)GAT>AAT	p.D334N	MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	334					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TGCCTGGCATCAACTATTATT	0.348													79	174					0	0	0	0	T	59147716	T	T	59147716	3	4	46	1	0	0	0	0	1	0	0	0	10154	826	29	2	1538	2	MYSM1	1	59147716	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	12646948	59147716	190102905	10	9424											
CACHD1	57685	broad.mit.edu	37	chr1	65117854	65117854	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taacccataggtttgataatGactgtgagtaaaccctgtta	13	13	8	7	0	0	3	0	3	0	0	0	3	0	3	2	1	2	3	2	1	6	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:65117854G>A	uc001dbo.1	+	10	1353	c.1248G>A	c.(1246-1248)ATG>ATA	p.M416I	CACHD1_uc001dbp.1_Missense_Mutation_p.M171I|CACHD1_uc001dbq.1_Missense_Mutation_p.M171I	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	467	Extracellular (Potential).|Cache 1.				calcium ion transport	integral to membrane				ovary(2)	2						GTTTGATAATGACTGTGAGTA	0.403													49	113					0	0	0	0	A	65117854	A	A	65117854	3	1	46	1	0	0	0	0	1	0	0	0	2549	1290	45	2	1286	2	CACHD1	1	65117854	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	5970138	65117854	184132767	11	9425											
GADD45A	1647	broad.mit.edu	37	chr1	68153400	68153400	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agtcaacttatttgtttttgCcgggaaagtcgctacatgga	10	14	10	7	2	1	0	1	0	0	0	2	2	1	2	1	2	3	2	1	2	4	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:68153400C>T	uc001ddz.1	+	4	736	c.441C>T	c.(439-441)TGC>TGT	p.C147C	GADD45A_uc009wbb.1_Silent_p.C113C|GADD45A_uc009wbc.1_RNA|GADD45A_uc009wbd.1_RNA	NM_001924	NP_001915	P24522	GA45A_HUMAN	growth arrest and DNA-damage-inducible, alpha	147					apoptosis|cell cycle arrest|cellular response to ionizing radiation|cellular response to mechanical stimulus|DNA repair|positive regulation of reactive oxygen species metabolic process|regulation of cyclin-dependent protein kinase activity|signal transduction in response to DNA damage	nucleus	protein binding			ovary(1)	1						TTTGTTTTTGCCGGGAAAGTC	0.353													4	239					0	0	0	0	T	68153400	T	T	68153400	2	4	46	1	0	0	0	0	0	0	0	1	6215	747	26	4		4	GADD45A	1	68153400	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	3035546	68153400	181097221	12	9426											
CLCA2	9635	broad.mit.edu	37	chr1	86919091	86919091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaaggaaatcagtaggcaGaaatgaggaggagcgaaagt	17	5	14	5	1	1	2	1	1	0	1	2	6	2	5	1	4	1	2	1	4	5	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:86919091G>A	uc001dlr.3	+	13	2357	c.2195G>A	c.(2194-2196)AGA>AAA	p.R732K		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	732	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		TCAGTAGGCAGAAATGAGGAG	0.453													4	108					0	0	0	0	A	86919091	A	A	86919091	3	1	46	1	0	0	0	0	1	0	0	0	3473	942	33	2	2245	2	CLCA2	1	86919091	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	18765691	86919091	162331530	13	9427											
LRRC8B	23507	broad.mit.edu	37	chr1	90049934	90049934	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gataatgagggaagcaaactGgttgtgttgaacaacttgaa	15	10	12	4	0	0	3	0	3	0	0	0	5	0	4	0	2	4	3	0	2	6	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:90049934G>T	uc001dni.2	+	7	2232	c.1725G>T	c.(1723-1725)CTG>CTT	p.L575L	LRRC8B_uc001dnh.2_Silent_p.L575L|LRRC8B_uc001dnj.2_Silent_p.L575L	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	575	LRR 5.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GAAGCAAACTGGTTGTGTTGA	0.463													4	94					0.00909568	0.00943256	1	0	T	90049934	T	T	90049934	2	4	46	1	0	0	0	0	0	0	0	1	9072	1335	47	4		4	LRRC8B	1	90049934	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	3130843	90049934	159200687	14	9428											
SARS	6301	broad.mit.edu	37	chr1	109778722	109778722	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttaccacattgtgaatattGtctcaggtatgggacccagc	10	12	9	10	0	1	1	1	1	1	0	2	2	1	2	2	2	2	1	2	2	4	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:109778722G>T	uc001dwu.1	+	8	1168	c.1093G>T	c.(1093-1095)GTC>TTC	p.V365F	SARS_uc001dwt.1_Missense_Mutation_p.V365F|SARS_uc001dwv.1_Missense_Mutation_p.V365F|SARS_uc001dww.1_Missense_Mutation_p.V298F|SARS_uc001dwx.1_Missense_Mutation_p.V317F|SARS_uc009wfa.1_Missense_Mutation_p.V365F|SARS_uc001dwy.1_Missense_Mutation_p.V190F|SARS_uc001dwz.1_Missense_Mutation_p.V190F	NM_006513	NP_006504	P49591	SYSC_HUMAN	seryl-tRNA synthetase	365					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	TGTGAATATTGTCTCAGGTAT	0.507													63	84					1.42676e-28	1.63895e-28	1	0	T	109778722	T	T	109778722	3	4	46	1	0	0	0	0	1	0	0	0	13909	1377	48	4	1123	4	SARS	1	109778722	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	19728788	109778722	139471899	15	9429											
ADORA3	140	broad.mit.edu	37	chr1	112031598	112031598	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgcagatggcagaagccGtgtccagcacaaagcttctc	11	8	11	11	1	1	2	0	0	1	2	3	2	2	2	2	1	4	5	2	1	2	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:112031598G>A	uc001ebf.2	-	3	1273	c.506C>T	c.(505-507)ACG>ATG	p.T169M	ADORA3_uc001ebg.3_Missense_Mutation_p.T88M	NM_020683	NP_065734	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 1	Error:Variant_position_missing_in_P33765_after_alignment					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GGCAGAAGCCGTGTCCAGCAC	0.398													33	80					0	0	0	0	A	112031598	A	A	112031598	3	1	46	1	0	0	0	0	1	0	0	0	329	1145	40	1	553	1	ADORA3	1	112031598	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	2252876	112031598	137219023	16	9430											
SYCP1	6847	broad.mit.edu	37	chr1	115489931	115489931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagcaacttgaaatagaaaGagaagagaaggtaggttttt	18	9	12	2	0	0	4	0	1	0	3	0	7	0	4	0	2	2	3	0	2	8	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:115489931G>A	uc001efr.2	+	27	2521	c.2312G>A	c.(2311-2313)AGA>AAA	p.R771K	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.R771K|SYCP1_uc009wgw.2_Intron	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	771	Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAATAGAAAGAGAAGAGAAG	0.294													43	116					0	0	0	0	A	115489931	A	A	115489931	3	1	46	1	0	0	0	0	1	0	0	0	15497	942	33	2	2414	2	SYCP1	1	115489931	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	3458333	115489931	133760690	17	9431											
SPAG17	200162	broad.mit.edu	37	chr1	118567969	118567969	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttttatagaactcatagtgCttcaccctctgggggtagct	8	14	10	9	0	3	1	2	0	1	1	3	1	3	1	1	2	3	4	1	2	5	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:118567969C>A	uc001ehk.2	-	27	3869	c.3801G>T	c.(3799-3801)AAG>AAT	p.K1267N		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1267						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ACTCATAGTGCTTCACCCTCT	0.458													71	151					2.72615e-36	3.21399e-36	1	0	A	118567969	A	A	118567969	3	1	46	1	0	0	0	0	1	0	0	0	15045	796	28	4	2958	4	SPAG17	1	118567969	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	3078038	118567969	130682652	18	9432											
NBPF7	343505	broad.mit.edu	37	chr1	120384093	120384093	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcctgcccctgggagttgtCatgcttatccggagtgagaa	7	11	13	10	1	1	1	1	1	0	1	3	4	3	3	4	2	2	2	4	2	2	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:120384093C>G	uc010oxk.1	-	3	1090	c.469G>C	c.(469-471)GAC>CAC	p.D157H		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	157						cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		TGGGAGTTGTCATGCTTATCC	0.577													5	304					0	0	0	0	G	120384093	G	G	120384093	3	3	46	1	0	0	0	0	1	0	0	0	10252	826	29	2	819	2	NBPF7	1	120384093	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	1816124	120384093	128866528	19	9433											
NBPF9	400818	broad.mit.edu	37	chr1	144621623	144621623	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aatgttttctaactcaactgGccggcttcctggccaaccag	9	11	8	13	1	2	0	1	0	1	0	3	0	3	0	4	3	3	2	4	3	4	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:144621623G>T	uc009wig.1	+	9	1031	c.955G>T	c.(955-957)GCC>TCC	p.A319S	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.A319S|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.A250S|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Missense_Mutation_p.A250S|NBPF9_uc010oyg.1_Missense_Mutation_p.A284S|NBPF9_uc009wii.1_Missense_Mutation_p.A48S	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	319						cytoplasm					0						AACTCAACTGGCCGGCTTCCT	0.428													5	397					3.59834e-05	3.80202e-05	1	0	T	144621623	T	T	144621623	3	4	46	1	0	0	0	0	1	0	0	0	10253	1203	42	4	975	4	NBPF9	1	144621623	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	24237530	144621623	104628998	20	9434											
SV2A	9900	broad.mit.edu	37	chr1	149879361	149879361	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggaatcctcaaaggacacTgacttgagccgcagcccaat	13	6	10	12	1	1	2	1	2	0	0	2	4	2	4	3	2	2	1	3	2	3	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:149879361T>C	uc001etg.2	-	10	2060	c.1569A>G	c.(1567-1569)TCA>TCG	p.S523S	SV2A_uc009wlk.2_5'Flank|SV2A_uc001eth.2_Silent_p.S523S	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	523	Extracellular (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CAAAGGACACTGACTTGAGCC	0.488													29	113					0	0	0	0	C	149879361	C	C	149879361	2	2	46	1	0	0	0	0	0	0	0	1	15483	1567	55	5		5	SV2A	1	149879361	Silent	SNP	T	TCGA-CN-4735-01A-01D-1434-08	5257738	149879361	99371260	21	9435											
ECM1	1893	broad.mit.edu	37	chr1	150484939	150484939	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggatgagtgctttgcccgtCgggctccttaccccaactat	6	11	11	13	2	0	1	0	1	0	0	2	2	1	2	4	2	4	2	4	2	3	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:150484939C>T	uc001eus.2	+	8	1394	c.1195C>T	c.(1195-1197)CGG>TGG	p.R399W	ECM1_uc001eut.2_Missense_Mutation_p.R274W|ECM1_uc001euu.2_Missense_Mutation_p.R428W|ECM1_uc001euv.2_Missense_Mutation_p.R426W|ECM1_uc009wlu.2_Missense_Mutation_p.R159W	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	399	2 X approximate repeats.|2.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTTTGCCCGTCGGGCTCCTTA	0.567													59	173					0	0	0	0	T	150484939	T	T	150484939	3	4	46	1	0	0	0	0	1	0	0	0	4919	875	31	1	1225	1	ECM1	1	150484939	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	605578	150484939	98765682	22	9436											
LASS2	29956	broad.mit.edu	37	chr1	150940906	150940906	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccactggtcaggtagaaatGttccaaggtggcgttgggag	9	9	16	7	1	1	1	1	0	0	1	2	2	2	2	2	5	0	3	2	5	3	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:150940906G>A	uc001evy.2	-	3	643	c.256C>T	c.(256-258)CAT>TAT	p.H86Y	LASS2_uc001evz.2_Missense_Mutation_p.H86Y|LASS2_uc009wmh.2_5'UTR	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	86	Cytoplasmic (Potential).|Homeobox.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGGTAGAAATGTTCCAAGGTG	0.572													42	89					0	0	0	0	A	150940906	A	A	150940906	3	1	46	1	0	0	0	0	1	0	0	0	8679	1377	48	4	922	4	LASS2	1	150940906	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	455967	150940906	98309715	23	9437											
OR10K1	391109	broad.mit.edu	37	chr1	158436255	158436255	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggaattcaaatcagccctaCgaagaacaatcggccaaact	17	6	7	11	2	2	1	2	0	0	1	3	3	2	2	2	2	4	0	2	2	7	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:158436255C>G	uc010pij.1	+	1	904	c.904C>G	c.(904-906)CGA>GGA	p.R302G		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					ATCAGCCCTACGAAGAACAAT	0.264													46	135					0	0	0	0	G	158436255	G	G	158436255	3	3	46	1	0	0	0	0	1	0	0	0	10967	528	19	3	906	3	OR10K1	1	158436255	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	7495349	158436255	90814366	24	9438											
CFH	3075	broad.mit.edu	37	chr1	196712640	196712640	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatatagtgtcgagacagatGagtaaatatccatctggtga	14	12	10	5	1	1	4	0	2	1	2	3	5	2	4	1	1	0	1	1	1	6	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:196712640G>A	uc001gtj.3	+	20	3432	c.3192G>A	c.(3190-3192)ATG>ATA	p.M1064I		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1064	Sushi 18.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CGAGACAGATGAGTAAATATC	0.403													68	189					0	0	0	0	A	196712640	A	A	196712640	3	1	46	1	0	0	0	0	1	0	0	0	3298	1290	45	2	3288	2	CFH	1	196712640	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	38276385	196712640	52537981	25	9439											
ASPM	259266	broad.mit.edu	37	chr1	197112028	197112028	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcatttctactagttcttCaaaaatagctttgggagatt	11	17	6	7	0	4	1	2	0	2	1	4	2	4	1	0	1	2	2	0	1	5	9			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:197112028C>G	uc001gtu.2	-	3	1611	c.1354G>C	c.(1354-1356)GAA>CAA	p.E452Q	ASPM_uc001gtv.2_Missense_Mutation_p.E452Q|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	452					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ACTAGTTCTTCAAAAATAGCT	0.338													6	289					0	0	0	0	G	197112028	G	G	197112028	3	3	46	1	0	0	0	0	1	0	0	0	1058	835	29	2	9183	2	ASPM	1	197112028	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	399388	197112028	52138593	26	9440											
PTPRC	5788	broad.mit.edu	37	chr1	198721488	198721488	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccttcgtgtctttgaactGagacattccaaggtatggaa	11	12	9	9	1	1	2	0	2	1	1	3	4	2	3	2	2	1	1	2	2	4	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr1:198721488G>A	uc001gur.1	+	30	3492	c.3312G>A	c.(3310-3312)CTG>CTA	p.L1104L	PTPRC_uc001gus.1_Silent_p.L1056L|PTPRC_uc001gut.1_Silent_p.L943L	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1104	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TCTTTGAACTGAGACATTCCA	0.378													19	148					0	0	0	0	A	198721488	A	A	198721488	2	1	46	1	0	0	0	0	0	0	0	1	12862	1277	45	2		2	PTPRC	1	198721488	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	1609460	198721488	50529133	27	9441											
DNAJC27	51277	broad.mit.edu	37	chr2	25186283	25186283	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctttcttacctcatagaaGaagggatgtccagccatatc	11	11	9	10	0	2	2	1	0	1	2	4	3	3	3	3	2	2	1	3	2	5	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:25186283G>T	uc002rft.1	-	3	282	c.231C>A	c.(229-231)TTC>TTA	p.F77L	DNAJC27_uc010ykn.1_Missense_Mutation_p.F6L|DNAJC27_uc002rfu.1_RNA|DNAJC27_uc010eyg.1_Missense_Mutation_p.F77L	NM_016544	NP_057628	Q9NZQ0	DJC27_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 27	77					protein folding|small GTPase mediated signal transduction		GTP binding|heat shock protein binding|unfolded protein binding			skin(1)	1						CCTCATAGAAGAAGGGATGTC	0.368													22	50					1.55795e-14	1.71911e-14	1	0	T	25186283	T	T	25186283	3	4	46	1	0	0	0	0	1	0	0	0	4667	933	33	2	610	2	DNAJC27	2	25186283	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08		25186283	218013090	28	9442											
SLC4A1AP	22950	broad.mit.edu	37	chr2	27887203	27887203	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccttttcgggaggctgtCtggctgcgacgtgtgcctgg	2	12	16	11	3	1	0	0	0	1	0	2	2	1	1	2	4	3	2	2	4	0	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:27887203C>G	uc002rlk.3	+	1	866	c.584C>G	c.(583-585)TCT>TGT	p.S195C	SUPT7L_uc002rlh.1_5'Flank|SUPT7L_uc002rli.1_5'Flank|SUPT7L_uc010ymf.1_5'Flank|SUPT7L_uc002rlj.1_5'Flank|SUPT7L_uc010ezh.1_5'Flank	NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	195	FHA.					cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					GGGAGGCTGTCTGGCTGCGAC	0.632													32	56					0	0	0	0	G	27887203	G	G	27887203	3	3	46	1	0	0	0	0	1	0	0	0	14717	913	32	2	586	2	SLC4A1AP	2	27887203	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	2700920	27887203	215312170	29	9443											
GPR75	10936	broad.mit.edu	37	chr2	54080671	54080671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggttcccttttcccatggctCgaagtcgagtcttttgtttg	4	17	10	10	2	1	0	0	0	1	0	5	2	3	0	2	2	0	3	2	2	1	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:54080671C>T	uc002rxo.3	-	2	1494	c.1223G>A	c.(1222-1224)CGA>CAA	p.R408Q	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	408	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCCCATGGCTCGAAGTCGAGT	0.448													94	183					0	0	0	0	T	54080671	T	T	54080671	3	4	46	1	0	0	0	0	1	0	0	0	6746	884	31	1	403	1	GPR75	2	54080671	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	26193468	54080671	189118702	30	9444											
CCDC85A	114800	broad.mit.edu	37	chr2	56419779	56419779	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccttatacctgcagaagctGaaagacctggaggtgaagca	13	7	12	9	0	0	4	0	2	0	2	0	5	0	5	3	2	4	3	3	2	5	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:56419779G>A	uc002rzn.2	+	2	946	c.444G>A	c.(442-444)CTG>CTA	p.L148L		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	148	Potential.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGCAGAAGCTGAAAGACCTGG	0.572													39	56					0	0	0	0	A	56419779	A	A	56419779	2	1	46	1	0	0	0	0	0	0	0	1	2872	1277	45	2		2	CCDC85A	2	56419779	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	2339108	56419779	186779594	31	9445											
ACTR2	10097	broad.mit.edu	37	chr2	65473816	65473816	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atagataccagaaattgtaaAatcttactcacagaacctcc	17	10	4	10	0	2	3	1	0	1	3	3	3	3	3	3	0	3	1	3	0	7	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:65473816A>T	uc002sdq.2	+	3	533	c.318A>T	c.(316-318)AAA>AAT	p.K106N	ACTR2_uc010yqf.1_Missense_Mutation_p.K51N|ACTR2_uc002sdp.2_Missense_Mutation_p.K111N|ACTR2_uc010yqg.1_Missense_Mutation_p.K54N	NM_005722	NP_005713	P61160	ARP2_HUMAN	actin-related protein 2 isoform b	106					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding				0						GAAATTGTAAAATCTTACTCA	0.368													72	154					0	0	0	0	T	65473816	T	T	65473816	3	4	46	1	0	0	0	0	1	0	0	0	211	11	1	5	347	5	ACTR2	2	65473816	Missense_Mutation	SNP	A	TCGA-CN-4735-01A-01D-1434-08	9054037	65473816	177725557	32	9446											
APLF	200558	broad.mit.edu	37	chr2	68765290	68765290	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatgcaaaggcaactgattCagttctacaaggttctgaag	13	10	10	8	0	3	2	1	2	2	0	3	2	3	2	0	2	3	5	0	2	5	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:68765290C>T	uc002sep.2	+	7	1264	c.1091C>T	c.(1090-1092)TCA>TTA	p.S364L	APLF_uc002seq.1_RNA|APLF_uc010fdf.2_Missense_Mutation_p.S340L|APLF_uc002ser.1_Missense_Mutation_p.S95L	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	364					double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						GCAACTGATTCAGTTCTACAA	0.443													64	88					0	0	0	0	T	68765290	T	T	68765290	3	4	46	1	0	0	0	0	1	0	0	0	776	838	29	2	1117	2	APLF	2	68765290	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	3291474	68765290	174434083	33	9447											
EXOC6B	23233	broad.mit.edu	37	chr2	72945308	72945308	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtctttgagatcggacataGaaacatcttttatttcttct	11	17	6	7	1	4	2	0	1	4	2	5	4	4	3	0	1	1	0	0	1	3	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:72945308G>A	uc010fep.2	-	6	731	c.593C>T	c.(592-594)TCT>TTT	p.S198F	EXOC6B_uc002sij.2_Missense_Mutation_p.S198F	NM_015189	NP_056004	Q9Y2D4	EXC6B_HUMAN	SEC15-like 2	198					protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2						ATCGGACATAGAAACATCTTT	0.438													56	104					0	0	0	0	A	72945308	A	A	72945308	3	1	46	1	0	0	0	0	1	0	0	0	5333	942	33	2	1910	2	EXOC6B	2	72945308	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	4180018	72945308	170254065	34	9448											
YSK4	80122	broad.mit.edu	37	chr2	135745305	135745305	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atttctggatcttgttcataGtttttggctactgaactctc	7	19	7	8	0	4	1	1	1	3	0	5	2	4	2	0	2	2	3	0	2	3	7			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:135745305G>A	uc002tue.1	-	7	1168	c.1137C>T	c.(1135-1137)AAC>AAT	p.N379N	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Silent_p.N266N|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Silent_p.N107N|YSK4_uc002tui.3_Silent_p.N396N	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	379							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTTGTTCATAGTTTTTGGCTA	0.378													56	99					0	0	0	0	A	135745305	A	A	135745305	2	1	46	1	0	0	0	0	0	0	0	1	17563	1020	36	4		4	YSK4	2	135745305	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	62799997	135745305	107454068	35	9449											
LRP1B	53353	broad.mit.edu	37	chr2	141072662	141072662	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcacaagttaacttacatGaatcatctgtttatgagaag	14	15	6	6	0	3	2	2	2	1	1	3	3	3	2	0	0	2	2	0	0	6	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:141072662G>T	uc002tvj.1	-	83	13619	c.12647C>A	c.(12646-12648)TCA>TAA	p.S4216*		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4216	Extracellular (Potential).|EGF-like 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAACTTACATGAATCATCTGT	0.303										TSP Lung(27;0.18)			27	62					3.28513e-13	3.55492e-13	1	0	T	141072662	T	T	141072662	4	4	46	1	0	0	0	0	0	1	0	0	9005	1294	45	2	1188	2	LRP1B	2	141072662	Nonsense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	5327357	141072662	102126711	36	9450											
CERKL	375298	broad.mit.edu	37	chr2	182468677	182468677	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcctttttcaagcagatgAagagtgtgatacctaataaa	14	13	8	6	0	1	4	1	2	0	2	2	4	2	4	2	0	2	2	2	0	6	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:182468677A>T	uc002unx.2	-	2	469	c.368T>A	c.(367-369)TTC>TAC	p.F123Y	CERKL_uc002uny.2_Missense_Mutation_p.F123Y|CERKL_uc010zfm.1_Missense_Mutation_p.F123Y|CERKL_uc002unz.2_5'UTR|CERKL_uc002uoa.2_Missense_Mutation_p.F123Y|CERKL_uc002uob.2_5'UTR|CERKL_uc002uoc.2_Missense_Mutation_p.F123Y|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_5'UTR|CERKL_uc002uoe.2_Missense_Mutation_p.F123Y	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	123					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CAAGCAGATGAAGAGTGTGAT	0.333													11	60					0	0	0	0	T	182468677	T	T	182468677	3	4	46	1	0	0	0	0	1	0	0	0	3283	246	9	5	1360	5	CERKL	2	182468677	Missense_Mutation	SNP	A	TCGA-CN-4735-01A-01D-1434-08	41396015	182468677	60730696	37	9451											
FAM171B	165215	broad.mit.edu	37	chr2	187626381	187626381	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaactcctcatatagtcctCagaaaaaggaaccatcaaag	19	7	5	10	0	3	1	3	0	0	1	5	2	5	2	3	1	2	0	3	1	8	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:187626381C>T	uc002ups.2	+	8	1424	c.1312C>T	c.(1312-1314)CAG>TAG	p.Q438*	FAM171B_uc002upr.1_Intron|FAM171B_uc002upt.2_5'Flank	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	438	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						ATATAGTCCTCAGAAAAAGGA	0.348													41	91					0	0	0	0	T	187626381	T	T	187626381	4	4	46	1	0	0	0	0	0	1	0	0	5519	827	29	2	1342	2	FAM171B	2	187626381	Nonsense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	5157704	187626381	55572992	38	9452											
MARS2	92935	broad.mit.edu	37	chr2	198570720	198570720	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gattcgtttcctgtatctctCgagagcgggcatccagtctc	6	13	10	12	3	2	1	0	0	2	1	8	3	4	1	2	1	1	3	2	1	1	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:198570720C>G	uc002uuq.2	+	1	634	c.591C>G	c.(589-591)CTC>CTG	p.L197L	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	197					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	CTGTATCTCTCGAGAGCGGGC	0.587													57	119					0	0	0	0	G	198570720	G	G	198570720	2	3	46	1	0	0	0	0	0	0	0	1	9370	871	31	3		3	MARS2	2	198570720	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	10944339	198570720	44628653	39	9453											
CHPF	79586	broad.mit.edu	37	chr2	220404983	220404983	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggccggagcagctgcactcGgcgagtgaggggccggcggc	5	3	20	13	6	0	1	0	1	0	0	1	3	0	2	2	7	3	3	2	7	0	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:220404983G>A	uc002vmc.3	-	4	1677	c.1450C>T	c.(1450-1452)CGA>TGA	p.R484*	CHPF_uc010zlh.1_Nonsense_Mutation_p.R322*	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	484	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		AGCTGCACTCGGCGAGTGAGG	0.667													14	32					0	0	0	0	A	220404983	A	A	220404983	4	1	46	1	0	0	0	0	0	1	0	0	3383	1124	39	1	881	1	CHPF	2	220404983	Nonsense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	21834263	220404983	22794390	40	9454											
CAPN10	11132	broad.mit.edu	37	chr2	241535795	241535795	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgccccccgtggctggcacCgcgtgccatgcatacgaccg	6	6	12	17	5	0	0	0	0	0	0	0	1	0	0	6	2	4	3	6	2	1	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr2:241535795C>T	uc002vzk.1	+	8	1522	c.1338C>T	c.(1336-1338)ACC>ACT	p.T446T	CAPN10_uc002vzl.1_Intron|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Silent_p.T318T|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	446	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		TGGCTGGCACCGCGTGCCATG	0.667													4	193					0	0	0	0	T	241535795	T	T	241535795	2	4	46	1	0	0	0	0	0	0	0	1	2635	639	23	1		1	CAPN10	2	241535795	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	21130812	241535795	1663578	41	9455											
GRM7	2917	broad.mit.edu	37	chr3	7188164	7188164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagattagttatgcatcaaCggcacccgagctaagtgatg	12	9	10	10	2	1	2	1	1	0	1	1	3	1	2	2	1	3	4	2	1	4	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:7188164C>T	uc003bqm.2	+	2	819	c.545C>T	c.(544-546)ACG>ATG	p.T182M	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.T182M|GRM7_uc003bql.2_Missense_Mutation_p.T182M	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	182	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TATGCATCAACGGCACCCGAG	0.502													64	56					0	0	0	0	T	7188164	T	T	7188164	3	4	46	1	0	0	0	0	1	0	0	0	6841	536	19	1	551	1	GRM7	3	7188164	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08		7188164	190834266	42	9456											
RAB5A	5868	broad.mit.edu	37	chr3	20025262	20025262	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attctgccagaggaagaggaGtagaccttaccgaacccaca	14	6	10	11	1	1	3	0	0	1	3	1	6	1	5	4	2	3	1	4	2	4	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:20025262G>A	uc003cbn.2	+	6	1130	c.595G>A	c.(595-597)GTA>ATA	p.V199I	RAB5A_uc010hey.2_RNA|RAB5A_uc011awg.1_Missense_Mutation_p.V185I|C3orf48_uc010hez.2_Intron	NM_004162	NP_004153	P20339	RAB5A_HUMAN	RAB5A, member RAS oncogene family	199					blood coagulation|protein transport|receptor internalization|regulation of filopodium assembly|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GDP binding|GTP binding|GTPase activity				0						AGGAAGAGGAGTAGACCTTAC	0.368													9	16					0	0	0	0	A	20025262	A	A	20025262	3	1	46	1	0	0	0	0	1	0	0	0	13013	1029	36	4	613	4	RAB5A	3	20025262	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	12837098	20025262	177997168	43	9457											
UBP1	7342	broad.mit.edu	37	chr3	33481236	33481236	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagcccagtacctcatgctGtaagcgccggcgcccagttc	7	7	12	15	3	1	0	1	0	0	0	2	1	1	1	4	2	4	4	4	2	2	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:33481236G>A	uc003cfq.3	-	1	635	c.105C>T	c.(103-105)TAC>TAT	p.Y35Y	UBP1_uc003cfr.3_Silent_p.Y35Y|UBP1_uc010hga.2_Silent_p.Y35Y	NM_014517	NP_055332	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a) isoform a	35					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			kidney(2)	2						ACCTCATGCTGTAAGCGCCGG	0.667													33	27					0	0	0	0	A	33481236	A	A	33481236	2	1	46	1	0	0	0	0	0	0	0	1	16963	1372	48	4		4	UBP1	3	33481236	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	13455974	33481236	164541194	44	9458											
SCN11A	11280	broad.mit.edu	37	chr3	38888755	38888755	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtattgaagttctctaaaatCacagcaatgtacatgttgac	14	13	7	7	0	2	2	1	2	1	0	3	2	2	2	0	0	2	5	0	0	6	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:38888755C>A	uc011ays.1	-	26	5005	c.4806G>T	c.(4804-4806)GTG>GTT	p.V1602V		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1602	IV.|Helical; Name=S6 of repeat IV; (By similarity).				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCTCTAAAATCACAGCAATGT	0.413													4	148					0.00024832	0.000261144	1	0	A	38888755	A	A	38888755	2	1	46	1	0	0	0	0	0	0	0	1	13978	813	29	2		2	SCN11A	3	38888755	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	5407519	38888755	159133675	45	9459											
ULK4	54986	broad.mit.edu	37	chr3	41877374	41877374	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctgggtggctacaagataGatcagctccccaagggttgg	10	8	13	10	0	1	2	1	0	0	2	2	2	2	2	3	4	2	3	3	4	4	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:41877374G>C	uc003ckv.3	-	18	1947	c.1746C>G	c.(1744-1746)ATC>ATG	p.I582M	ULK4_uc003ckw.2_Missense_Mutation_p.I582M	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	582							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CTACAAGATAGATCAGCTCCC	0.393													4	166					0	0	0	0	C	41877374	C	C	41877374	3	2	46	1	0	0	0	0	1	0	0	0	17046	932	33	2	2161	2	ULK4	3	41877374	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	2988619	41877374	156145056	46	9460											
PDE12	201626	broad.mit.edu	37	chr3	57543358	57543358	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaaagaactgctggagaaaCtagttttgtacccatcagcg	14	9	9	9	1	1	2	1	0	0	2	1	3	1	2	1	1	5	3	1	1	5	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:57543358C>G	uc003diw.3	+	1	1378	c.1252C>G	c.(1252-1254)CTA>GTA	p.L418V	PDE12_uc003div.2_Missense_Mutation_p.L418V	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	418							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		GCTGGAGAAACTAGTTTTGTA	0.468													50	41					0	0	0	0	G	57543358	G	G	57543358	3	3	46	1	0	0	0	0	1	0	0	0	11686	564	20	4	1254	4	PDE12	3	57543358	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	15665984	57543358	140479072	47	9461											
STXBP5L	9515	broad.mit.edu	37	chr3	121100262	121100262	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgcacggaaaaatgactctAccatctctccttgtctgttc	9	14	6	12	1	3	1	0	1	3	0	6	2	4	2	2	1	2	2	2	1	3	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:121100262A>G	uc003eec.3	+	23	2682	c.2542A>G	c.(2542-2544)ACC>GCC	p.T848A	STXBP5L_uc011bji.1_Missense_Mutation_p.T824A	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	848	WD 11.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AAATGACTCTACCATCTCTCC	0.408													108	263					0	0	0	0	G	121100262	G	G	121100262	3	3	46	1	0	0	0	0	1	0	0	0	15423	391	14	5	2628	5	STXBP5L	3	121100262	Missense_Mutation	SNP	A	TCGA-CN-4735-01A-01D-1434-08	63556904	121100262	76922168	48	9462											
MED12L	116931	broad.mit.edu	37	chr3	151148153	151148153	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccttggtgcggcagctcCagaagcagctttccagtaag	8	8	12	13	2	0	1	0	0	0	1	2	1	2	1	4	2	4	5	4	2	2	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:151148153C>G	uc003eyp.2	+	42	6408	c.6370C>G	c.(6370-6372)CAG>GAG	p.Q2124E	MED12L_uc011bnz.1_Missense_Mutation_p.Q1788E	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	2124	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCGGCAGCTCCAGAAGCAGCT	0.537													47	150					0	0	0	0	G	151148153	G	G	151148153	3	3	46	1	0	0	0	0	1	0	0	0	9482	595	21	4	6536	4	MED12L	3	151148153	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	30047891	151148153	46874277	49	9463											
P2RY1	5028	broad.mit.edu	37	chr3	152554038	152554038	+	Missense_Mutation	SNP	C	T	T																															gtacagcggtgtggtgtaccCcctcaagtccctgggccggc																										TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:152554038C>T	uc003ezq.2	+	1	1303	c.467C>T	c.(466-468)CCC>CTC	p.P156L		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	156	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			GTGGTGTACCCCCTCAAGTCC	0.527													31	135					0	0	0	0	T	152554038	T	T	152554038	3	4	46	1	0	0	0	0	1	0	0	0	11400	623	22	4	469	4	P2RY1	3	152554038	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	1405885	152554038	45468392	50	9464	22	2									
P2RY1	5028	broad.mit.edu	37	chr3	152554042	152554042	+	Silent	SNP	C	T	T																															agcggtgtggtgtaccccctCaagtccctgggccggctcaa																										TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:152554042C>T	uc003ezq.2	+	1	1307	c.471C>T	c.(469-471)CTC>CTT	p.L157L		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	157	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TGTACCCCCTCAAGTCCCTGG	0.532													31	138					0	0	0	0	T	152554042	T	T	152554042	2	4	46	1	0	0	0	0	0	0	0	1	11400	813	29	2		2	P2RY1	3	152554042	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	4	152554042	45468388	51	9465	22	2									
P2RY1	5028	broad.mit.edu	37	chr3	152554482	152554482	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttcaatgacagggtttatgCcacgtatcaggtgacaagag	12	11	11	7	1	2	3	2	2	0	1	2	3	2	3	1	2	1	2	1	2	4	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:152554482C>T	uc003ezq.2	+	1	1747	c.911C>T	c.(910-912)GCC>GTC	p.A304V		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	304	Helical; Name=7; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			AGGGTTTATGCCACGTATCAG	0.478													5	264					0	0	0	0	T	152554482	T	T	152554482	3	4	46	1	0	0	0	0	1	0	0	0	11400	739	26	4	913	4	P2RY1	3	152554482	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	440	152554482	45467948	52	9466											
VEPH1	79674	broad.mit.edu	37	chr3	156979086	156979086	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgggggagagagcggtccCtgcgtttcttggccacagcc	5	7	15	14	3	1	1	0	0	1	1	2	3	2	2	4	4	3	1	4	4	0	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:156979086C>A	uc003fbj.1	-	14	2656	c.2339G>T	c.(2338-2340)AGG>ATG	p.R780M	VEPH1_uc003fbk.1_Missense_Mutation_p.R780M|VEPH1_uc010hvu.1_Missense_Mutation_p.R735M	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	780	PH.					plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			AGAGCGGTCCCTGCGTTTCTT	0.483													4	226					0.000602214	0.000630355	1	0	A	156979086	A	A	156979086	3	1	46	1	0	0	0	0	1	0	0	0	17222	681	24	4	166	4	VEPH1	3	156979086	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	4424604	156979086	41043344	53	9467											
SERPINI2	5276	broad.mit.edu	37	chr3	167167167	167167167	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaaactttttgcgtcacttGggaaacatacacttcagatg	13	12	8	8	1	2	1	2	0	0	1	2	3	2	2	0	1	4	0	0	1	4	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:167167167G>A	uc003fer.1	-	6	1046	c.988C>T	c.(988-990)CAA>TAA	p.Q330*	SERPINI2_uc003fes.1_Nonsense_Mutation_p.Q340*|SERPINI2_uc003fet.1_Nonsense_Mutation_p.Q330*	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	330					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						TGCGTCACTTGGGAAACATAC	0.338													3	89					0	0	0	0	A	167167167	A	A	167167167	4	1	46	1	0	0	0	0	0	1	0	0	14184	1357	47	4	241	4	SERPINI2	3	167167167	Nonsense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	10188081	167167167	30855263	54	9468											
KLHL6	89857	broad.mit.edu	37	chr3	183225976	183225976	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccagaagcggtaagcgcacGttctcgaggacataggggag	11	6	15	9	4	1	1	0	0	1	1	3	4	2	3	1	4	2	3	1	4	3	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr3:183225976G>A	uc003flr.2	-	3	838	c.780C>T	c.(778-780)AAC>AAT	p.N260N	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Silent_p.N258N	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	260	BACK.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GTAAGCGCACGTTCTCGAGGA	0.522													89	217					0	0	0	0	A	183225976	A	A	183225976	2	1	46	1	0	0	0	0	0	0	0	1	8432	1136	40	1		1	KLHL6	3	183225976	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	16058809	183225976	14796454	55	9469											
BOD1L	259282	broad.mit.edu	37	chr4	13602595	13602595	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcagcactagtcataggacCctcacaacctcctggaactg	11	8	8	14	0	2	0	2	0	0	0	3	2	3	2	3	2	4	2	3	2	4	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr4:13602595C>G	uc003gmz.1	-	10	6046	c.5929G>C	c.(5929-5931)GGT>CGT	p.G1977R	BOD1L_uc010idr.1_Missense_Mutation_p.G1314R	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1977							DNA binding			ovary(5)|breast(1)	6						GTCATAGGACCCTCACAACCT	0.483													44	51					0	0	0	0	G	13602595	G	G	13602595	3	3	46	1	0	0	0	0	1	0	0	0	1486	623	22	4	3294	4	BOD1L	4	13602595	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08		13602595	177551681	56	9470											
REST	5978	broad.mit.edu	37	chr4	57785989	57785989	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtgaactttgtccttactCaagttctcagaagactcatc	11	14	6	10	0	3	3	3	1	1	2	6	3	4	3	1	0	2	1	1	0	4	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr4:57785989C>G	uc003hch.2	+	3	1282	c.935C>G	c.(934-936)TCA>TGA	p.S312*	REST_uc003hci.2_Nonsense_Mutation_p.S312*|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	312	C2H2-type 5.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					TGTCCTTACTCAAGTTCTCAG	0.328													40	44					0	0	0	0	G	57785989	G	G	57785989	4	3	46	1	0	0	0	0	0	1	0	0	13299	838	29	2	941	2	REST	4	57785989	Nonsense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	44183394	57785989	133368287	57	9471											
CENPE	1062	broad.mit.edu	37	chr4	104068527	104068527	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttactttagccaaagtttCtctaatatgttctttcagct	10	18	4	9	0	3	0	1	0	2	0	4	0	3	0	1	0	3	3	1	0	5	8			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr4:104068527C>T	uc003hxb.1	-	29	4210	c.4120G>A	c.(4120-4122)GAA>AAA	p.E1374K	CENPE_uc003hxc.1_Missense_Mutation_p.E1349K	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1374	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GCCAAAGTTTCTCTAATATGT	0.323													7	100					0	0	0	0	T	104068527	T	T	104068527	3	4	46	1	0	0	0	0	1	0	0	0	3245	922	32	2	4069	2	CENPE	4	104068527	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	46282538	104068527	87085749	58	9472											
IRX4	50805	broad.mit.edu	37	chr5	1879734	1879734	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttgttccgcggcggccacGtcatcttgttctccttcttg	3	15	9	14	4	4	0	1	0	3	0	6	0	5	0	3	2	0	2	3	2	0	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:1879734G>T	uc003jcz.2	-	4	739	c.620C>A	c.(619-621)ACG>AAG	p.T207K	IRX4_uc011cmf.1_Missense_Mutation_p.T68K	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	207					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		CGGCGGCCACGTCATCTTGTT	0.478													35	73					1.06647e-15	1.18262e-15	1	0	T	1879734	T	T	1879734	3	4	46	1	0	0	0	0	1	0	0	0	7885	1145	40	3	947	3	IRX4	5	1879734	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08		1879734	179035526	59	9473											
ADCY2	108	broad.mit.edu	37	chr5	7802384	7802384	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcatgtttgcctccattccGgatttcaaagaattttatac	10	16	6	9	1	2	1	2	0	0	1	4	2	4	2	3	1	2	1	3	1	4	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:7802384G>A	uc003jdz.1	+	21	2749	c.2682G>A	c.(2680-2682)CCG>CCA	p.P894P	ADCY2_uc011cmo.1_Silent_p.P714P|ADCY2_uc010itm.1_Silent_p.P90P	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	894	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CCTCCATTCCGGATTTCAAAG	0.473													32	53					0	0	0	0	A	7802384	A	A	7802384	2	1	46	1	0	0	0	0	0	0	0	1	294	1103	39	1		1	ADCY2	5	7802384	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	5922650	7802384	173112876	60	9474											
FBXL7	23194	broad.mit.edu	37	chr5	15928296	15928296	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctgcgcgcgagtgtgccGccgctggtacaacctggcct	4	7	14	16	6	0	0	0	0	0	0	0	1	0	0	5	2	4	3	5	2	2	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:15928296G>A	uc003jfn.1	+	3	906	c.425G>A	c.(424-426)CGC>CAC	p.R142H		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	142	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CGAGTGTGCCGCCGCTGGTAC	0.672													9	15					0	0	0	0	A	15928296	A	A	15928296	3	1	46	1	0	0	0	0	1	0	0	0	5756	1087	38	1	435	1	FBXL7	5	15928296	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	8125912	15928296	164986964	61	9475											
CDH10	1008	broad.mit.edu	37	chr5	24509693	24509693	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctaatggggctggaaataGaatctgggtcccttgccatt	10	11	11	9	0	1	1	0	0	1	1	2	2	2	2	3	4	1	1	3	4	4	4	rs1395027		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:24509693G>C	uc003jgr.1	-	7	1570	c.1238C>G	c.(1237-1239)TCT>TGT	p.S413C	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	413	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GCTGGAAATAGAATCTGGGTC	0.294										HNSCC(23;0.051)			43	75					0	0	0	0	C	24509693	C	C	24509693	3	2	46	1	0	0	0	0	1	0	0	0	3111	942	33	2	1152	2	CDH10	5	24509693	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	8581397	24509693	156405567	62	9476											
MRPS30	10884	broad.mit.edu	37	chr5	44813211	44813211	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttattttgctcttcaggctCaaaaactgcagatccttgct	9	16	6	10	0	3	1	2	0	1	1	4	1	4	1	1	1	4	4	1	1	3	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:44813211C>T	uc003joh.2	+	4	895	c.857C>T	c.(856-858)TCA>TTA	p.S286L		NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	286					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					TCTTCAGGCTCAAAAACTGCA	0.373													21	128					0	0	0	0	T	44813211	T	T	44813211	3	4	46	1	0	0	0	0	1	0	0	0	9893	838	29	2	871	2	MRPS30	5	44813211	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	20303518	44813211	136102049	63	9477											
PDE4D	5144	broad.mit.edu	37	chr5	59284492	59284492	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggacaagatagggttccattCcgcggaaagggtcttcctct	9	10	12	10	2	2	1	0	0	2	1	5	3	5	3	3	4	0	1	3	4	3	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:59284492C>T	uc003jsb.2	-	3	308	c.95G>A	c.(94-96)GGA>GAA	p.G32E	PDE4D_uc010iwj.1_Missense_Mutation_p.G32E|PDE4D_uc003jse.1_Missense_Mutation_p.G44E	NM_006203	NP_006194	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 2	Error:Variant_position_missing_in_Q08499_after_alignment					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GGGTTCCATTCCGCGGAAAGG	0.428													56	126					0	0	0	0	T	59284492	T	T	59284492	3	4	46	1	0	0	0	0	1	0	0	0	11696	855	30	2	2721	2	PDE4D	5	59284492	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	14471281	59284492	121630768	64	9478											
SV2C	22987	broad.mit.edu	37	chr5	75621244	75621244	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggcagcagccgtcctgggaAacttaatatttggctctctg	9	11	11	10	1	1	0	0	0	1	0	3	1	2	1	2	3	3	3	2	3	3	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:75621244A>C	uc003kei.1	+	13	2190	c.2056A>C	c.(2056-2058)AAC>CAC	p.N686H		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	686	Helical; (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CGTCCTGGGAAACTTAATATT	0.522													82	138					0	0	0	0	C	75621244	C	C	75621244	3	2	46	1	0	0	0	0	1	0	0	0	15485	14	1	5	2102	5	SV2C	5	75621244	Missense_Mutation	SNP	A	TCGA-CN-4735-01A-01D-1434-08	16336752	75621244	105294016	65	9479											
KCNN2	3781	broad.mit.edu	37	chr5	113831873	113831873	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaccaacttcatcagagagTagctagaagagaataagtta	17	8	8	8	0	2	3	2	0	0	3	2	5	2	3	2	0	2	3	2	0	7	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:113831873T>C	uc003kqo.2	+	8	2191	c.1734T>C	c.(1732-1734)AGT>AGC	p.S578S	KCNN2_uc003kqp.2_Silent_p.S230S|KCNN2_uc010jcg.2_RNA|uc003kqr.1_RNA	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	578						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CATCAGAGAGTAGCTAGAAGA	0.458													3	192					0	0	0	0	C	113831873	C	C	113831873	2	2	46	1	0	0	0	0	0	0	0	1	8118	1635	57	5		5	KCNN2	5	113831873	Silent	SNP	T	TCGA-CN-4735-01A-01D-1434-08	38210629	113831873	67083387	66	9480											
SLC22A4	6583	broad.mit.edu	37	chr5	131630361	131630361	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcgagtgggggcccttcCagcgcctcatcttcttcctg	3	11	13	14	2	3	0	1	0	2	0	5	1	5	0	4	3	1	0	4	3	0	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:131630361C>G	uc003kwq.2	+	1	217	c.52C>G	c.(52-54)CAG>GAG	p.Q18E	uc003kwm.3_Intron|SLC22A4_uc010jdq.1_5'Flank	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	18	Cytoplasmic (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GGGGCCCTTCCAGCGCCTCAT	0.617													26	58					0	0	0	0	G	131630361	G	G	131630361	3	3	46	1	0	0	0	0	1	0	0	0	14520	595	21	4	54	4	SLC22A4	5	131630361	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	17798488	131630361	49284899	67	9481											
SLC22A4	6583	broad.mit.edu	37	chr5	131630460	131630460	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggaccccggagcaccgctgtCgagtgccggacgccgcgaac	7	3	15	16	7	0	0	0	0	0	0	1	5	0	3	5	3	3	2	5	3	1	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:131630460C>G	uc003kwq.2	+	1	316	c.151C>G	c.(151-153)CGA>GGA	p.R51G	uc003kwm.3_Intron|SLC22A4_uc010jdq.1_5'Flank	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	51	Extracellular (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GCACCGCTGTCGAGTGCCGGA	0.672													24	47					0	0	0	0	G	131630460	G	G	131630460	3	3	46	1	0	0	0	0	1	0	0	0	14520	876	31	3	153	3	SLC22A4	5	131630460	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	99	131630460	49284800	68	9482											
PCDHB3	56132	broad.mit.edu	37	chr5	140481978	140481978	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgccccgggcggctgagcCgggctacctggtgaccaagg	5	5	18	13	3	0	2	0	2	0	0	0	2	0	2	5	6	3	2	5	6	2	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr5:140481978C>T	uc003lio.2	+	1	1745	c.1745C>T	c.(1744-1746)CCG>CTG	p.P582L	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	582	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGGCTGAGCCGGGCTACCTG	0.701													63	115					0	0	0	0	T	140481978	T	T	140481978	3	4	46	1	0	0	0	0	1	0	0	0	11597	652	23	1	1747	1	PCDHB3	5	140481978	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	8851518	140481978	40433282	69	9483											
C6orf146	222826	broad.mit.edu	37	chr6	4069240	4069240	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttggcatggacttaaaataGaacttttgggattcttatca	12	15	8	6	0	2	1	1	0	1	1	2	3	2	3	0	3	1	1	0	3	5	7			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:4069240G>C	uc003mvx.2	-	7	1557	c.1217C>G	c.(1216-1218)TCT>TGT	p.S406C	C6orf146_uc010jnq.1_Intron|C6orf146_uc003mvy.2_Missense_Mutation_p.S343C	NM_173563	NP_775834	Q8IXS0	CF146_HUMAN	hypothetical protein LOC222826	406										ovary(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				ACTTAAAATAGAACTTTTGGG	0.368													74	50					0	0	0	0	C	4069240	C	C	4069240	3	2	46	1	0	0	0	0	1	0	0	0	2345	942	33	2	313	2	C6orf146	6	4069240	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08		4069240	167045827	70	9484											
HDGFL1	154150	broad.mit.edu	37	chr6	22570125	22570125	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcggagacgggccttggccGgagcccgaggccgcagaggg	7	2	20	12	5	0	2	0	0	0	2	0	5	0	3	4	6	2	1	4	6	0	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:22570125G>A	uc003nds.2	+	1	448	c.321G>A	c.(319-321)CCG>CCA	p.P107P		NM_138574	NP_612641	Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	107											0	Ovarian(93;0.163)					GGCCTTGGCCGGAGCCCGAGG	0.687													2	3					0	0	0	0	A	22570125	A	A	22570125	2	1	46	1	0	0	0	0	0	0	0	1	7058	1103	39	1		1	HDGFL1	6	22570125	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	18500885	22570125	148544942	71	9485											
SYNGAP1	8831	broad.mit.edu	37	chr6	33402927	33402927	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgaacctcctgcctgccAgggcccggctgatgcaaagc	7	7	11	16	1	0	2	0	2	0	0	2	2	2	2	6	2	5	2	6	2	2	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:33402927A>T	uc011dri.1	+	6	705	c.510_splice	c.e6-2	p.R170_splice	SYNGAP1_uc003oeo.1_Splice_Site_p.R155_splice|SYNGAP1_uc010juy.2_Splice_Site_p.R155_splice|SYNGAP1_uc010juz.2_5'Flank	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1						negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CCTGCCTGCCAGGGCCCGGCT	0.403													4	158					0	0	0	0	T	33402927	T	T	33402927	5	4	46	1	0	0	0	0	0	0	1	0	15513	202	7	5	530	5	SYNGAP1	6	33402927	Splice_Site	SNP	A	TCGA-CN-4735-01A-01D-1434-08	10832802	33402927	137712140	72	9486											
KATNA1	11104	broad.mit.edu	37	chr6	149959867	149959869	+	5'Flank	DEL	TTT	-	-																															ctcctttaaaaaaaacattgTtttttttttttttttttttt																										TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr6:149959867_149959869delTTT	uc003qmr.1	-						KATNA1_uc003qms.2_Intron|KATNA1_uc003qmt.2_Intron|KATNA1_uc011eed.1_5'Flank	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1						cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		AAAAACATTGttttttttttttt	0.187													---	---	---								-	149959869	-	-	149959867	6	5	46	0	1	1	0	1	0	0	0	0	8023	1740	60	0		0	KATNA1	6	149959867	5'Flank	DEL	TTT	TCGA-CN-4735-01A-01D-1434-08	116556940	149959867	21155200	73	9487											
PCLO	27445	broad.mit.edu	37	chr7	82582957	82582957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttaacttttttttaggaaGaatagttggtttaggtgaag	11	18	11	1	0	0	2	0	1	0	1	0	3	0	3	0	3	1	3	0	3	7	9			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:82582957G>A	uc003uhx.2	-	5	7601	c.7312C>T	c.(7312-7314)CTT>TTT	p.L2438F	PCLO_uc003uhv.2_Missense_Mutation_p.L2438F|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2369	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTTTAGGAAGAATAGTTGGT	0.249													13	11					0	0	0	0	A	82582957	A	A	82582957	3	1	46	1	0	0	0	0	1	0	0	0	11637	942	33	2	8217	2	PCLO	7	82582957	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08		82582957	76555706	74	9488											
GAL3ST4	79690	broad.mit.edu	37	chr7	99757768	99757768	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcagtgatgtatttggggTcagaagcctcaccccctacc	9	10	10	12	0	3	2	3	1	0	1	3	3	3	2	4	2	2	1	4	2	3	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:99757768T>C	uc003utt.2	-	3	2261	c.1244A>G	c.(1243-1245)GAC>GGC	p.D415G	C7orf43_uc010lgp.2_5'Flank|C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.D415G|GAL3ST4_uc010lgq.2_Missense_Mutation_p.D353G	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	415	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTATTTGGGGTCAGAAGCCTC	0.587													75	343					0	0	0	0	C	99757768	C	C	99757768	3	2	46	1	0	0	0	0	1	0	0	0	6235	1667	58	5	220	5	GAL3ST4	7	99757768	Missense_Mutation	SNP	T	TCGA-CN-4735-01A-01D-1434-08	17174811	99757768	59380895	75	9489											
NAPEPLD	222236	broad.mit.edu	37	chr7	102743965	102743965	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttaagtccgtatctctctaGagcttcattcagcttcactg	8	15	7	11	1	5	1	3	0	2	1	7	1	6	1	1	0	2	4	1	0	3	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:102743965G>C	uc003vbc.2	-	5	1421	c.1093C>G	c.(1093-1095)CTA>GTA	p.L365V	NAPEPLD_uc003vbd.2_Missense_Mutation_p.L365V|NAPEPLD_uc011klj.1_Missense_Mutation_p.L438V|NAPEPLD_uc003vbe.2_RNA	NM_198990	NP_945341	Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	365					phospholipid catabolic process	membrane	metal ion binding			skin(1)	1						TATCTCTCTAGAGCTTCATTC	0.333													51	185					0	0	0	0	C	102743965	C	C	102743965	3	2	46	1	0	0	0	0	1	0	0	0	10216	933	33	2	92	2	NAPEPLD	7	102743965	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	2986197	102743965	56394698	76	9490											
DNAJC2	27000	broad.mit.edu	37	chr7	102953456	102953456	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcttctgctattttttcccAtctttcaggtgtatttactg	5	20	6	10	1	3	0	1	0	2	0	4	0	4	0	1	1	2	3	1	1	3	9			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:102953456A>G	uc003vbo.2	-	16	1980	c.1729T>C	c.(1729-1731)TGG>CGG	p.W577R	PMPCB_uc003vbl.2_3'UTR|PMPCB_uc003vbm.2_3'UTR|PMPCB_uc010liv.2_3'UTR|PMPCB_uc010liw.2_3'UTR|PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.2_Missense_Mutation_p.W202R|DNAJC2_uc010lix.2_Missense_Mutation_p.W524R|DNAJC2_uc003vbp.2_Missense_Mutation_p.W202R	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	577	SANT 2.				'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1						ATTTTTTCCCATCTTTCAGGT	0.398													150	651					0	0	0	0	G	102953456	G	G	102953456	3	3	46	1	0	0	0	0	1	0	0	0	4661	217	8	5	144	5	DNAJC2	7	102953456	Missense_Mutation	SNP	A	TCGA-CN-4735-01A-01D-1434-08	209491	102953456	56185207	77	9491											
PSMC2	5701	broad.mit.edu	37	chr7	102988177	102988178	+	Missense_Mutation	DNP	GC	TT	TT																															aaatgccggattacctcggtGccgatcagcggaagaccaaa																										TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr7:102988177_102988178GC>TT	uc003vbs.2	+	1	89_90	c.19_20GC>TT	c.(19-21)GCC>TTC	p.A7F	DNAJC2_uc003vbo.2_5'Flank|DNAJC2_uc010lix.2_5'Flank|DNAJC2_uc003vbp.2_5'Flank|DNAJC2_uc003vbq.1_5'Flank|DNAJC2_uc003vbr.1_5'Flank|PSMC2_uc011kln.1_Missense_Mutation_p.A7F|PSMC2_uc011klo.1_5'UTR	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	7					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TTACCTCGGTGCCGATCAGCGG	0.579													35	270					0	0	0	0	TT	102988178	TT	TT	102988177	3	4	46	1	0	0	0	0	1	0	0	0	12748	1319	46	4	21	4	PSMC2	7	102988177	Missense_Mutation	DNP	GC	TCGA-CN-4735-01A-01D-1434-08	34721	102988177	56150486	78	9492											
MFHAS1	9258	broad.mit.edu	37	chr8	8748457	8748457	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgctctcatgcaggtaggaGagggcactctgcagtcggtc	7	8	14	12	2	2	1	1	0	2	1	5	2	2	1	1	4	2	5	1	4	1	1	rs150651778		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:8748457G>A	uc003wsj.1	-	1	2675	c.2112C>T	c.(2110-2112)CTC>CTT	p.L704L		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	704											0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GCAGGTAGGAGAGGGCACTCT	0.627													26	40					0	0	0	0	A	8748457	A	A	8748457	2	1	46	1	0	0	0	0	0	0	0	1	9574	929	33	2		2	MFHAS1	8	8748457	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08		8748457	137615565	79	9493											
MFHAS1	9258	broad.mit.edu	37	chr8	8748738	8748738	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccggtggttgagcaggtattGaaaatgggccttgcgccgtc	7	10	15	9	3	0	2	0	2	0	0	1	2	0	2	3	4	2	3	3	4	3	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:8748738G>C	uc003wsj.1	-	1	2394	c.1831C>G	c.(1831-1833)CAA>GAA	p.Q611E		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	611	Roc.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		AGCAGGTATTGAAAATGGGCC	0.627													49	97					0	0	0	0	C	8748738	C	C	8748738	3	2	46	1	0	0	0	0	1	0	0	0	9574	1299	45	2	1339	2	MFHAS1	8	8748738	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	281	8748738	137615284	80	9494											
SCARA5	286133	broad.mit.edu	37	chr8	27737157	27737157	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcatgcggcacaccacgtctCcgtccttcttgtcccagccg	5	9	9	18	4	2	0	0	0	2	0	5	0	4	0	5	1	2	2	5	1	0	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:27737157C>T	uc003xgj.2	-	8	1720	c.1280G>A	c.(1279-1281)GGA>GAA	p.G427E	SCARA5_uc010luz.2_Missense_Mutation_p.G202E	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	427	SRCR.|Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CACCACGTCTCCGTCCTTCTT	0.637													74	151					0	0	0	0	T	27737157	T	T	27737157	3	4	46	1	0	0	0	0	1	0	0	0	13945	855	30	2	215	2	SCARA5	8	27737157	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	18988419	27737157	118626865	81	9495											
CSMD3	114788	broad.mit.edu	37	chr8	113267588	113267588	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagctgaatgaaacctctgActggtatataaagcttttgc	12	12	9	8	0	1	3	0	3	1	0	1	3	1	3	1	1	4	4	1	1	6	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:113267588A>G	uc003ynu.2	-	62	10090	c.9931T>C	c.(9931-9933)TCA>CCA	p.S3311P	CSMD3_uc003yns.2_Missense_Mutation_p.S2513P|CSMD3_uc003ynt.2_Missense_Mutation_p.S3271P|CSMD3_uc011lhx.1_Missense_Mutation_p.S3142P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3311	Extracellular (Potential).|Sushi 26.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GAAACCTCTGACTGGTATATA	0.413										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			49	88					0	0	0	0	G	113267588	G	G	113267588	3	3	46	1	0	0	0	0	1	0	0	0	3963	275	10	5	1232	5	CSMD3	8	113267588	Missense_Mutation	SNP	A	TCGA-CN-4735-01A-01D-1434-08	85530431	113267588	33096434	82	9496											
FAM83H	286077	broad.mit.edu	37	chr8	144812752	144812752	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctgagagcgacgggccaTgttggggccaggggcctgga	6	6	19	10	2	1	1	0	1	1	1	1	4	1	2	3	6	1	2	3	6	0	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr8:144812752T>C	uc003yzk.2	-	2	70	c.1A>G	c.(1-3)ATG>GTG	p.M1V	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	1					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CGACGGGCCATGTTGGGGCCA	0.657													12	25					0	0	0	0	C	144812752	C	C	144812752	3	2	46	1	0	0	0	0	1	0	0	0	5672	1464	51	5	3554	5	FAM83H	8	144812752	Missense_Mutation	SNP	T	TCGA-CN-4735-01A-01D-1434-08	31545164	144812752	1551270	83	9497											
SMARCA2	6595	broad.mit.edu	37	chr9	2097460	2097460	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaccacccatatatgtttCagcacattgaggtaagtctg	12	11	8	10	0	2	1	1	1	1	0	2	1	2	1	2	1	2	4	2	1	4	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:2097460C>A	uc003zhc.2	+	21	3166	c.3067C>A	c.(3067-3069)CAG>AAG	p.Q1023K	SMARCA2_uc003zhd.2_Missense_Mutation_p.Q1023K|SMARCA2_uc010mha.2_Missense_Mutation_p.Q956K	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1023					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATATATGTTTCAGCACATTGA	0.353													64	50					2.10369e-13	2.28751e-13	1	0	A	2097460	A	A	2097460	3	1	46	1	0	0	0	0	1	0	0	0	14833	827	29	2	3145	2	SMARCA2	9	2097460	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08		2097460	139115971	84	9498											
BAT2L1	84726	broad.mit.edu	37	chr9	134350562	134350562	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccatgccacttttggccgcGaggccaccaaatttgaagag	10	8	11	12	2	0	2	0	1	0	1	0	3	0	2	5	2	1	0	5	2	2	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:134350562G>A	uc004can.3	+	15	3101	c.3046G>A	c.(3046-3048)GAG>AAG	p.E1016K	BAT2L1_uc010mzj.1_Missense_Mutation_p.E599K|BAT2L1_uc004cao.3_Missense_Mutation_p.E374K	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1016							protein binding				0						TTTTGGCCGCGAGGCCACCAA	0.562													20	10					0	0	0	0	A	134350562	A	A	134350562	3	1	46	1	0	0	0	0	1	0	0	0	1322	1059	37	1	3104	1	BAT2L1	9	134350562	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	132253102	134350562	6862869	85	9499											
UBAC1	10422	broad.mit.edu	37	chr9	138825301	138825301	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgcagcatgacaggccccGtttctggatcattcatccac	8	11	8	14	1	4	1	2	1	2	0	5	2	5	2	3	2	2	3	3	2	0	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:138825301G>A	uc004cgt.2	-	10	1381	c.1163C>T	c.(1162-1164)ACG>ATG	p.T388M	UBAC1_uc004cgs.1_Intron|UBAC1_uc004cgu.2_RNA	NM_016172	NP_057256	Q9BSL1	UBAC1_HUMAN	ubiquitin associated domain containing 1	388	STI1.					Golgi apparatus|plasma membrane	protein binding			skin(2)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.1e-06)|Epithelial(140;7.79e-06)		GACAGGCCCCGTTTCTGGATC	0.562													86	62					0	0	0	0	A	138825301	A	A	138825301	3	1	46	1	0	0	0	0	1	0	0	0	16902	1145	40	1	58	1	UBAC1	9	138825301	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	4474739	138825301	2388130	86	9500											
EHMT1	79813	broad.mit.edu	37	chr9	140708936	140708936	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactgcatgtgcggccagctCagcatgcgctgctggtacga	8	8	13	12	3	1	0	1	0	0	0	1	1	1	0	1	2	8	6	1	2	2	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr9:140708936C>T	uc011mfc.1	+	22	3271	c.3234C>T	c.(3232-3234)CTC>CTT	p.L1078L	EHMT1_uc004coe.2_5'Flank	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1078	Pre-SET.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GCGGCCAGCTCAGCATGCGCT	0.642													48	32					0	0	0	0	T	140708936	T	T	140708936	2	4	46	1	0	0	0	0	0	0	0	1	5005	813	29	2		2	EHMT1	9	140708936	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	1883635	140708936	504495	87	9501											
AGAP4	119016	broad.mit.edu	37	chr10	46322371	46322371	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggtggagatgggtgtgcaGgccgatgtggctagggatgg	7	8	22	4	1	0	1	0	0	0	1	0	5	0	2	1	7	1	2	1	7	1	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:46322371G>A	uc001jcx.3	-	7	1110	c.984C>T	c.(982-984)GCC>GCT	p.A328A	AGAP4_uc010qfl.1_Silent_p.A351A|AGAP4_uc001jcy.3_Silent_p.A243A	NM_133446	NP_597703	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	328	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			ovary(1)	1						TGGGTGTGCAGGCCGATGTGG	0.488													72	216					0	0	0	0	A	46322371	A	A	46322371	2	1	46	1	0	0	0	0	0	0	0	1	370	987	35	4		4	AGAP4	10	46322371	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08		46322371	89212376	88	9502											
KIAA1274	27143	broad.mit.edu	37	chr10	72324152	72324152	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaagaggcgcaagaaatgcgGaggctgcagctgcggagcct	12	4	16	9	3	0	2	0	0	0	2	0	4	0	4	1	4	5	4	1	4	3	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:72324152G>A	uc001jrd.3	+	19	2576	c.2295G>A	c.(2293-2295)CGG>CGA	p.R765R	KIAA1274_uc001jre.3_Silent_p.R56R	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	765										ovary(2)|central_nervous_system(1)	3						AAGAAATGCGGAGGCTGCAGC	0.617													31	131					0	0	0	0	A	72324152	A	A	72324152	2	1	46	1	0	0	0	0	0	0	0	1	8259	1161	41	2		2	KIAA1274	10	72324152	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	26001781	72324152	63210595	89	9503											
UNC5B	219699	broad.mit.edu	37	chr10	73050857	73050857	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	accccgtcaactttaagacgGcaaggcccagtaagaacccg	13	5	9	14	3	1	2	1	0	0	2	1	2	1	2	4	2	2	2	4	2	5	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:73050857G>A	uc001jro.2	+	9	1730	c.1285G>A	c.(1285-1287)GCA>ACA	p.A429T	UNC5B_uc001jrp.2_Missense_Mutation_p.A418T	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	429	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						CTTTAAGACGGCAAGGCCCAG	0.597													6	451					0	0	0	0	A	73050857	A	A	73050857	3	1	46	1	0	0	0	0	1	0	0	0	17060	1203	42	4	1319	4	UNC5B	10	73050857	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	726705	73050857	62483890	90	9504											
SLC16A12	387700	broad.mit.edu	37	chr10	91203593	91203605	+	Frame_Shift_Del	DEL	TCCACAAAAAAAA	-	-																															gagtgaagtatgtctggaacTccacaaaaaaaattgagata																										TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:91203593_91203605delTCCACAAAAAAAA	uc001kgm.2	-	4	513_525	c.122_134delTTTTTTTTGTGGA	c.(121-135)ATTTTTTTTGTGGAGfs	p.I41fs		NM_213606	NP_998771	Q6ZSM3	MOT12_HUMAN	solute carrier family 16 (monocarboxylic acid	41_45	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			skin(1)	1						TGTCTGGAACTCCACAAAAAAAATTGAGATACA	0.371													---	---	---								-	91203605	-	-	91203593	7	5	46	1	0	1	0	1	0	0	0	0	14470	1551	54	0	1346	0	SLC16A12	10	91203593	Frame_Shift_Del	DEL	TCCACAAAAAAAA	TCGA-CN-4735-01A-01D-1434-08	18152736	91203593	44331154	91	9505											
SCD	6319	broad.mit.edu	37	chr10	102114253	102114253	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaacacatgctgatcctCataattcccgacgtggcttt	11	11	7	12	2	1	2	1	1	0	1	3	3	3	2	2	1	2	2	2	1	2	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:102114253C>A	uc001kqy.2	+	4	1001	c.511C>A	c.(511-513)CAT>AAT	p.H171N		NM_005063	NP_005054	O00767	ACOD_HUMAN	stearoyl-CoA desaturase 1	171	Cytoplasmic (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity				0		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TGCTGATCCTCATAATTCCCG	0.502													69	163					3.31162e-33	3.84354e-33	1	0	A	102114253	A	A	102114253	3	1	46	1	0	0	0	0	1	0	0	0	13951	826	29	2	525	2	SCD	10	102114253	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	10910660	102114253	33420494	92	9506											
FBXW4	6468	broad.mit.edu	37	chr10	103432746	103432746	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagttcacctcctgttcatGagccgagtacttgacagtga	10	11	9	11	1	2	3	2	3	0	0	3	4	3	3	3	0	2	3	3	0	1	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:103432746G>A	uc001kto.2	-	4	947	c.601C>T	c.(601-603)CAT>TAT	p.H201Y		NM_022039	NP_071322	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	201	WD 2.				ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				skin(1)	1		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		TCCTGTTCATGAGCCGAGTAC	0.507													42	74					0	0	0	0	A	103432746	A	A	103432746	3	1	46	1	0	0	0	0	1	0	0	0	5799	1290	45	2	661	2	FBXW4	10	103432746	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	1318493	103432746	32102001	93	9507											
ATRNL1	26033	broad.mit.edu	37	chr10	117704253	117704253	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttctggagtccggaatcGaaaacacctttcaacacgtc	12	9	8	12	3	2	0	1	0	1	0	5	4	3	2	2	2	2	0	2	2	4	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr10:117704253G>T	uc001lcg.2	+	29	4489	c.4103G>T	c.(4102-4104)CGA>CTA	p.R1368L	ATRNL1_uc010qsm.1_Missense_Mutation_p.R497L|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1368	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GTCCGGAATCGAAAACACCTT	0.418													69	142					1.77791e-30	2.05285e-30	1	0	T	117704253	T	T	117704253	3	4	46	1	0	0	0	0	1	0	0	0	1209	1058	37	3	4217	3	ATRNL1	10	117704253	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	14271507	117704253	17830494	94	9508											
SYT8	90019	broad.mit.edu	37	chr11	1858221	1858221	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccagctcatgctgaaccaGaggaagtggaagaagagaaa	16	5	13	7	0	1	4	1	1	0	3	2	7	2	6	2	2	3	2	2	2	5	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:1858221G>A	uc001lue.1	+	8	995	c.867G>A	c.(865-867)CAG>CAA	p.Q289Q	SYT8_uc001lud.2_Silent_p.Q289Q|SYT8_uc001luf.1_Silent_p.Q275Q|TNNI2_uc010qxc.1_5'Flank|TNNI2_uc010qxd.1_5'Flank	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	289	C2 2.|Cytoplasmic (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGCTGAACCAGAGGAAGTGGA	0.627													8	89					0	0	0	0	A	1858221	A	A	1858221	2	1	46	1	0	0	0	0	0	0	0	1	15546	933	33	2		2	SYT8	11	1858221	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08		1858221	133148295	95	9509											
TSPAN32	10077	broad.mit.edu	37	chr11	2335794	2335794	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcagggagaggaggcggCgagagaggtgagggggggac	9	3	25	4	2	1	3	1	1	0	2	1	8	1	5	0	8	0	0	0	8	0	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:2335794C>T	uc001lvy.1	+	6	673	c.536C>T	c.(535-537)GCG>GTG	p.A179V	TSPAN32_uc001lvx.1_3'UTR|TSPAN32_uc009ydk.1_Missense_Mutation_p.A189V|TSPAN32_uc010qxk.1_Missense_Mutation_p.A214V|TSPAN32_uc009ydl.1_RNA|TSPAN32_uc001lvz.1_Missense_Mutation_p.A149V|TSPAN32_uc001lwb.1_Missense_Mutation_p.A149V|TSPAN32_uc001lwc.1_Missense_Mutation_p.A124V|TSPAN32_uc001lwd.1_5'Flank	NM_139022	NP_620591	Q96QS1	TSN32_HUMAN	tumor-suppressing subtransferable candidate 6	179					cell-cell signaling	integral to membrane				central_nervous_system(1)	1		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		GAGGAGGCGGCGAGAGAGGTG	0.652													9	7					0	0	0	0	T	2335794	T	T	2335794	3	4	46	1	0	0	0	0	1	0	0	0	16714	768	27	1	558	1	TSPAN32	11	2335794	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	477573	2335794	132670722	96	9510											
KCNA4	3739	broad.mit.edu	37	chr11	30032952	30032952	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgccacccccctgttgcTgggccaggtcagtgcccagt	5	9	11	16	0	1	0	1	0	0	0	1	0	1	0	6	2	3	2	6	2	0	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:30032952T>A	uc001msk.2	-	2	2426	c.1274A>T	c.(1273-1275)CAG>CTG	p.Q425L		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	425						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCCCTGTTGCTGGGCCAGGTC	0.507													57	44					0	0	0	0	A	30032952	A	A	30032952	3	1	46	1	0	0	0	0	1	0	0	0	8044	1580	55	5	691	5	KCNA4	11	30032952	Missense_Mutation	SNP	T	TCGA-CN-4735-01A-01D-1434-08	27697158	30032952	104973564	97	9511											
OR4C16	219428	broad.mit.edu	37	chr11	55340373	55340373	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttgcatatttatgtacaCatgccttgcaaccgtattcc	10	14	5	12	1	0	0	0	0	0	0	1	0	1	0	4	0	5	4	4	0	5	8			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:55340373C>A	uc010rih.1	+	1	770	c.770C>A	c.(769-771)ACA>AAA	p.T257K		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	257	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TTTATGTACACATGCCTTGCA	0.398													53	109					3.76997e-23	4.24358e-23	1	0	A	55340373	A	A	55340373	3	1	46	1	0	0	0	0	1	0	0	0	11103	478	17	4	772	4	OR4C16	11	55340373	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	25307421	55340373	79666143	98	9512											
OR5M10	390167	broad.mit.edu	37	chr11	56344940	56344940	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagatggtcttctgttctgaGaggaaattgtgcagcatatt	10	14	12	5	0	3	2	0	1	3	2	3	5	3	3	0	2	2	3	0	2	2	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:56344940G>A	uc001niz.1	-	1	258	c.258C>T	c.(256-258)CTC>CTT	p.L86L		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTGTTCTGAGAGGAAATTGT	0.438													44	86					0	0	0	0	A	56344940	A	A	56344940	2	1	46	1	0	0	0	0	0	0	0	1	11227	929	33	2		2	OR5M10	11	56344940	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	1004567	56344940	78661576	99	9513											
PCNXL3	399909	broad.mit.edu	37	chr11	65383829	65383829	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgccagggggtgtgggcctCgctcaccggcggttggttct	2	9	18	12	4	2	0	1	0	1	0	3	0	2	0	3	6	0	3	3	6	0	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:65383829C>T	uc001oey.2	+	1	47	c.47C>T	c.(46-48)TCG>TTG	p.S16L	MAP3K11_uc001oew.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	16						integral to membrane					0						GTGTGGGCCTCGCTCACCGGC	0.667													9	9					0	0	0	0	T	65383829	T	T	65383829	3	4	46	1	0	0	0	0	1	0	0	0	11647	893	31	1	49	1	PCNXL3	11	65383829	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	9038889	65383829	69622687	100	9514											
NUDT8	254552	broad.mit.edu	37	chr11	67395614	67395615	+	Missense_Mutation	DNP	GG	TA	TA																															gacccggtgtggtccatgcaGgaagacgggtagtgtgtagc																										TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:67395614_67395615GG>TA	uc001omo.1	-	4	532_533	c.513_514CC>TA	c.(511-516)TTCCTG>TTTATG	p.L172M	NUDT8_uc001omn.2_3'UTR	NM_181843	NP_862826	Q8WV74	NUDT8_HUMAN	nudix-type motif 8	172	Nudix hydrolase.					mitochondrion	hydrolase activity|metal ion binding				0						GGTCCATGCAGGAAGACGGGTA	0.639													28	132					0	0	0	0	TA	67395615	TA	TA	67395614	3	4	46	1	0	0	0	0	1	0	0	0	10799	1015	35	4		4	NUDT8	11	67395614	Missense_Mutation	DNP	GG	TCGA-CN-4735-01A-01D-1434-08	2011785	67395614	67610902	101	9515											
FOLR1	2348	broad.mit.edu	37	chr11	71906662	71906662	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaaatcacccaggtggatCagagctggcgcaaagagcgg	13	5	13	10	2	3	2	3	0	0	2	3	3	3	3	1	4	2	2	1	4	3	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:71906662C>T	uc001orz.1	+	5	502	c.364C>T	c.(364-366)CAG>TAG	p.Q122*	FOLR1_uc001osa.1_Nonsense_Mutation_p.Q122*|FOLR1_uc001osb.1_Nonsense_Mutation_p.Q122*|FOLR1_uc001osc.1_Nonsense_Mutation_p.Q122*|FOLR1_uc001osd.1_Nonsense_Mutation_p.Q122*	NM_016724	NP_057936	P15328	FOLR1_HUMAN	folate receptor 1 precursor	122					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			ovary(1)	1						CCAGGTGGATCAGAGCTGGCG	0.542													28	199					0	0	0	0	T	71906662	T	T	71906662	4	4	46	1	0	0	0	0	0	1	0	0	6013	827	29	2	374	2	FOLR1	11	71906662	Nonsense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	4511048	71906662	63099854	102	9516											
ARHGEF17	9828	broad.mit.edu	37	chr11	73021005	73021005	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccgtgccaaaggacctggagGcacctctagggcattgaggg	9	6	15	11	1	1	1	0	1	1	0	1	3	1	3	4	5	1	2	4	5	2	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:73021005G>A	uc001otu.2	+	1	1343	c.1322G>A	c.(1321-1323)GGC>GAC	p.G441D		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	441					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GGACCTGGAGGCACCTCTAGG	0.607													37	29					0	0	0	0	A	73021005	A	A	73021005	3	1	46	1	0	0	0	0	1	0	0	0	900	1203	42	4	1324	4	ARHGEF17	11	73021005	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	1114343	73021005	61985511	103	9517											
TYR	7299	broad.mit.edu	37	chr11	88911535	88911535	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaaattttttgcctacctCactttagcaaagcataccat	13	13	4	11	0	1	0	1	0	0	0	1	1	1	0	3	0	5	2	3	0	5	7			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:88911535C>T	uc001pcs.2	+	1	496	c.414C>T	c.(412-414)CTC>CTT	p.L138L		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	138	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TTGCCTACCTCACTTTAGCAA	0.438									Oculocutaneous_Albinism				13	136					0	0	0	0	T	88911535	T	T	88911535	2	4	46	1	0	0	0	0	0	0	0	1	16881	813	29	2		2	TYR	11	88911535	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	15890530	88911535	46094981	104	9518											
HEPN1	641654	broad.mit.edu	37	chr11	124789685	124789685	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaattgctccatgggttgaTggcgaatcagagctggagtt	9	11	15	6	1	1	2	1	1	0	1	2	5	2	4	1	4	2	4	1	4	2	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr11:124789685T>A	uc001qbj.1	+	1	540	c.39T>A	c.(37-39)GAT>GAA	p.D13E	HEPACAM_uc009zbj.2_3'UTR|HEPACAM_uc001qbk.2_3'UTR	NM_001037558	NP_001032647	Q6WQI6	HEPN1_HUMAN	HEPACAM opposite strand 1	13						cytoplasm					0	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0287)		CATGGGTTGATGGCGAATCAG	0.517													39	37					0	0	0	0	A	124789685	A	A	124789685	3	1	46	1	0	0	0	0	1	0	0	0	7095	1461	51	5	41	5	HEPN1	11	124789685	Missense_Mutation	SNP	T	TCGA-CN-4735-01A-01D-1434-08	35878150	124789685	10216831	105	9519											
CACNA1C	775	broad.mit.edu	37	chr12	2595407	2595407	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaagatgcacaagacctgcTacaaccaggagggcatagca	15	4	12	10	0	0	2	0	0	0	2	0	4	0	4	2	3	5	4	2	3	5	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:2595407T>C	uc009zdu.1	+	6	1208	c.895T>C	c.(895-897)TAC>CAC	p.Y299H	CACNA1C_uc009zdv.1_Missense_Mutation_p.Y299H|CACNA1C_uc001qkb.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkc.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qke.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkf.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qjz.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkd.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkg.2_Missense_Mutation_p.Y299H|CACNA1C_uc009zdw.1_Missense_Mutation_p.Y299H|CACNA1C_uc001qkh.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkl.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkn.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qko.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkp.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkr.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qku.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkq.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qks.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qkt.2_Missense_Mutation_p.Y299H|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_Missense_Mutation_p.Y35H|CACNA1C_uc001qkj.1_Missense_Mutation_p.Y35H|CACNA1C_uc001qkk.1_Missense_Mutation_p.Y35H|CACNA1C_uc001qkm.1_Missense_Mutation_p.Y35H	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	299	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CAAGACCTGCTACAACCAGGA	0.602													16	61					0	0	0	0	C	2595407	C	C	2595407	3	2	46	1	0	0	0	0	1	0	0	0	2552	1522	53	5	917	5	CACNA1C	12	2595407	Missense_Mutation	SNP	T	TCGA-CN-4735-01A-01D-1434-08		2595407	131256488	106	9520											
CLEC4E	26253	broad.mit.edu	37	chr12	8689784	8689784	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctttaaacttaacgcccagGaaatggtgtcagtagaaaag	15	10	9	7	1	2	1	1	0	1	1	2	2	2	2	1	2	2	1	1	2	7	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:8689784G>A	uc001quo.1	-	4	464	c.299C>T	c.(298-300)TCC>TTC	p.S100F		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	100	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					TAACGCCCAGGAAATGGTGTC	0.463													47	77					0	0	0	0	A	8689784	A	A	8689784	3	1	46	1	0	0	0	0	1	0	0	0	3530	1174	41	2	372	2	CLEC4E	12	8689784	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	6094377	8689784	125162111	107	9521											
ATF7IP	55729	broad.mit.edu	37	chr12	14577111	14577111	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaggaagtaaagcagaaTggaaggaaacaccctgtatc	17	6	11	7	0	0	2	0	1	0	1	1	5	0	5	1	3	2	3	1	3	8	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:14577111T>C	uc001rbw.2	+	2	420	c.262T>C	c.(262-264)TGG>CGG	p.W88R	ATF7IP_uc010shs.1_Missense_Mutation_p.W88R|ATF7IP_uc001rbu.2_Missense_Mutation_p.W88R|ATF7IP_uc001rbv.1_Missense_Mutation_p.W88R|ATF7IP_uc001rbx.2_Missense_Mutation_p.W88R|ATF7IP_uc010sht.1_Missense_Mutation_p.W88R|ATF7IP_uc001rby.3_Missense_Mutation_p.W88R|ATF7IP_uc001rbz.1_Missense_Mutation_p.W88R|ATF7IP_uc001rca.2_Missense_Mutation_p.W88R|ATF7IP_uc001rcb.2_5'Flank	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	88					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						TAAAGCAGAATGGAAGGAAAC	0.378													34	67					0	0	0	0	C	14577111	C	C	14577111	3	2	46	1	0	0	0	0	1	0	0	0	1089	1464	51	5	264	5	ATF7IP	12	14577111	Missense_Mutation	SNP	T	TCGA-CN-4735-01A-01D-1434-08	5887327	14577111	119274784	108	9522											
MLL2	8085	broad.mit.edu	37	chr12	49445126	49445126	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtggctcctcaggcacagcGcataggcatggctcctcagg	7	8	13	13	1	2	0	2	0	0	0	4	0	4	0	2	5	1	5	2	5	1	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:49445126G>T	uc001rta.3	-	10	2340	c.2340C>A	c.(2338-2340)TGC>TGA	p.C780*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	780	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CAGGCACAGCGCATAGGCATG	0.667			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			27	39					1.30293e-26	1.48907e-26	1	0	T	49445126	T	T	49445126	4	4	46	1	0	0	0	0	0	1	0	0	9674	1079	38	3	14453	3	MLL2	12	49445126	Nonsense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	34868015	49445126	84406769	109	9523											
HOXC9	3225	broad.mit.edu	37	chr12	54396297	54396297	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtaccagacgctggaactgGagaaggagtttctcttcaat	12	10	11	8	1	2	2	1	0	1	2	3	5	2	4	1	3	2	3	1	3	4	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:54396297G>A	uc001sep.2	+	3	720	c.622G>A	c.(622-624)GAG>AAG	p.E208K	HOXC9_uc001seq.2_Missense_Mutation_p.E208K	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	208	Homeobox.				multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						GCTGGAACTGGAGAAGGAGTT	0.557													62	119					0	0	0	0	A	54396297	A	A	54396297	3	1	46	1	0	0	0	0	1	0	0	0	7356	1175	41	2	628	2	HOXC9	12	54396297	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	4951171	54396297	79455598	110	9524											
R3HDM2	22864	broad.mit.edu	37	chr12	57648863	57648863	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtacgggtgatgccctcaGggagatctgtcacctccagc	8	8	12	13	1	3	2	2	1	1	1	4	3	4	2	3	2	3	1	3	2	1	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:57648863G>A	uc009zpm.1	-	22	2659	c.2624C>T	c.(2623-2625)CCT>CTT	p.P875L	R3HDM2_uc010srn.1_Intron|R3HDM2_uc001snu.2_Missense_Mutation_p.P570L|R3HDM2_uc001snr.2_Missense_Mutation_p.P602L|R3HDM2_uc001sns.2_Missense_Mutation_p.P875L|R3HDM2_uc001snt.2_Missense_Mutation_p.P889L|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	875						nucleus	nucleic acid binding			ovary(2)	2						GATGCCCTCAGGGAGATCTGT	0.602													48	91					0	0	0	0	A	57648863	A	A	57648863	3	1	46	1	0	0	0	0	1	0	0	0	12953	1000	35	4	310	4	R3HDM2	12	57648863	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	3252566	57648863	76203032	111	9525											
SLC26A10	65012	broad.mit.edu	37	chr12	58018675	58018675	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggtcccggggctctgcatCctgagctatccaacaccact	8	8	9	16	1	1	1	0	1	1	0	4	1	4	1	4	3	3	3	4	3	2	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:58018675C>A	uc001spe.2	+	10	1565	c.1254C>A	c.(1252-1254)ATC>ATA	p.I418I	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_RNA	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	418	STAS.					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					GGCTCTGCATCCTGAGCTATC	0.577													78	165					7.68447e-34	8.96522e-34	1	0	A	58018675	A	A	58018675	2	1	46	1	0	0	0	0	0	0	0	1	14579	845	30	2		2	SLC26A10	12	58018675	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	369812	58018675	75833220	112	9526											
TMEM132D	121256	broad.mit.edu	37	chr12	130184678	130184678	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcccctccggctggtccacGgacttcctcctcccggcaac	4	8	9	20	3	0	0	0	0	0	0	6	1	6	1	7	4	1	2	7	4	1	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:130184678G>A	uc009zyl.1	-	2	973	c.645C>T	c.(643-645)TCC>TCT	p.S215S		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	215	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCTGGTCCACGGACTTCCTCC	0.692													40	79					0	0	0	0	A	130184678	A	A	130184678	2	1	46	1	0	0	0	0	0	0	0	1	16113	1103	39	1		1	TMEM132D	12	130184678	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	72166003	130184678	3667217	113	9527											
ZNF10	7556	broad.mit.edu	37	chr12	133732286	133732286	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacatttgaggcaagtggcaTtcacccaaaagaaagtactt	15	9	9	8	0	1	2	1	1	0	1	1	3	1	2	1	2	1	3	1	2	5	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr12:133732286T>G	uc009zzb.2	+	5	901	c.454T>G	c.(454-456)TTC>GTC	p.F152V	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.F152V	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	152				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GCAAGTGGCATTCACCCAAAA	0.413													43	64					0	0	0	0	G	133732286	G	G	133732286	3	3	46	1	0	0	0	0	1	0	0	0	17779	1493	52	5	468	5	ZNF10	12	133732286	Missense_Mutation	SNP	T	TCGA-CN-4735-01A-01D-1434-08	3547608	133732286	119609	114	9528											
RIPK3	11035	broad.mit.edu	37	chr14	24808260	24808260	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagcaggacgttggatggCttgaggtcccggtgcaggag	7	8	17	9	2	0	1	0	1	0	0	2	4	2	4	2	6	2	4	2	6	0	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:24808260C>T	uc001wpb.2	-	3	642	c.432G>A	c.(430-432)AAG>AAA	p.K144K	RIPK3_uc001wpa.2_5'UTR|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_5'UTR|RIPK3_uc010toj.1_Silent_p.K144K	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	144	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		CGTTGGATGGCTTGAGGTCCC	0.627													30	34					0	0	0	0	T	24808260	T	T	24808260	2	4	46	1	0	0	0	0	0	0	0	1	13447	796	28	4		4	RIPK3	14	24808260	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08		24808260	82541280	115	9529											
MIA2	117153	broad.mit.edu	37	chr14	39716525	39716525	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attgaacctgtacaagaaagCtcatttcggagtagaaaaat	17	10	8	6	1	1	3	1	1	0	2	2	4	1	4	1	1	3	3	1	1	7	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:39716525C>T	uc001wux.2	+	4	941	c.747C>T	c.(745-747)AGC>AGT	p.S249S	MIA2_uc010amy.1_Silent_p.S180S	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	249						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		TACAAGAAAGCTCATTTCGGA	0.403													46	25					0	0	0	0	T	39716525	T	T	39716525	2	4	46	1	0	0	0	0	0	0	0	1	9617	796	28	4		4	MIA2	14	39716525	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	14908265	39716525	67633015	116	9530											
PTGER2	5732	broad.mit.edu	37	chr14	52781581	52781581	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtggcactggcgcccgaGagccgcgcgtgcacctactt	5	7	14	15	5	0	1	0	0	0	1	0	2	0	1	3	3	3	2	3	3	1	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:52781581G>A	uc001wzr.2	+	1	566	c.315G>A	c.(313-315)GAG>GAA	p.E105E		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	105	Extracellular (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	TGGCGCCCGAGAGCCGCGCGT	0.647													26	63					0	0	0	0	A	52781581	A	A	52781581	2	1	46	1	0	0	0	0	0	0	0	1	12806	933	33	2		2	PTGER2	14	52781581	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	13065056	52781581	54567959	117	9531											
C14orf169	79697	broad.mit.edu	37	chr14	73959252	73959252	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acttcattcacgattctctgCcccctgttttgactgatagg	7	15	7	12	1	3	2	2	2	1	0	4	3	3	2	2	1	1	1	2	1	1	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:73959252C>T	uc001xok.1	+	3	1610	c.1531C>T	c.(1531-1533)CCC>TCC	p.P511S	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	511					negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)		CGATTCTCTGCCCCCTGTTTT	0.562													39	16					0	0	0	0	T	73959252	T	T	73959252	3	4	46	1	0	0	0	0	1	0	0	0	1764	747	26	4	1532	4	C14orf169	14	73959252	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	21177671	73959252	33390288	118	9532											
FBLN5	10516	broad.mit.edu	37	chr14	92357640	92357640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataggatccaggaacattcgCacagagctgctggcagtaac	13	7	11	10	1	0	1	0	0	0	1	2	3	1	3	1	3	4	5	1	3	3	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr14:92357640C>T	uc001xzx.3	-	6	1017	c.544G>A	c.(544-546)GCG>ACG	p.A182T	FBLN5_uc010aud.2_Missense_Mutation_p.A187T|FBLN5_uc010aue.2_Missense_Mutation_p.A223T	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	182	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				GGAACATTCGCACAGAGCTGC	0.473													79	29					0	0	0	0	T	92357640	T	T	92357640	3	4	46	1	0	0	0	0	1	0	0	0	5732	710	25	4	826	4	FBLN5	14	92357640	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	18398388	92357640	14991900	119	9533											
FMN1	342184	broad.mit.edu	37	chr15	33359987	33359987	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaatagggatttcatagaGaacttactcaggatcgactg	14	10	9	8	1	2	1	2	0	0	1	3	5	2	3	1	2	2	0	1	2	5	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:33359987G>A	uc001zhf.3	-	1	99	c.99C>T	c.(97-99)TTC>TTT	p.F33F	FMN1_uc001zhg.2_Silent_p.F33F	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:Variant_position_missing_in_Q68DA7_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		ATTTCATAGAGAACTTACTCA	0.428													42	68					0	0	0	0	A	33359987	A	A	33359987	2	1	46	1	0	0	0	0	0	0	0	1	5981	933	33	2		2	FMN1	15	33359987	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08		33359987	69171405	120	9534											
THBS1	7057	broad.mit.edu	37	chr15	39876366	39876366	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcaccattgtgaccacgcTgcaggacagcatccgcaaag	11	5	11	14	3	0	1	0	1	0	0	1	2	1	2	3	1	2	5	3	1	1	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:39876366T>C	uc001zkh.2	+	5	1060	c.881T>C	c.(880-882)CTG>CCG	p.L294P		NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	294					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GTGACCACGCTGCAGGACAGC	0.557													19	42					0	0	0	0	C	39876366	C	C	39876366	3	2	46	1	0	0	0	0	1	0	0	0	15919	1580	55	5	895	5	THBS1	15	39876366	Missense_Mutation	SNP	T	TCGA-CN-4735-01A-01D-1434-08	6516379	39876366	62655026	121	9535											
MAPK6	5597	broad.mit.edu	37	chr15	52339091	52339091	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggctcaagtatattcactCtgcaaatgtactgcacagag	12	10	10	9	0	3	1	2	0	1	1	3	1	3	1	0	2	3	5	0	2	5	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr15:52339091C>G	uc002abp.2	+	2	1228	c.434C>G	c.(433-435)TCT>TGT	p.S145C		NM_002748	NP_002739	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	145	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(3)|ovary(1)	4				all cancers(107;0.0028)		TATATTCACTCTGCAAATGTA	0.468													71	96					0	0	0	0	G	52339091	G	G	52339091	3	3	46	1	0	0	0	0	1	0	0	0	9334	913	32	2	436	2	MAPK6	15	52339091	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	12462725	52339091	50192301	122	9536											
ABCA3	21	broad.mit.edu	37	chr16	2376444	2376444	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagttcttccagaggaggagCgccagctgcctgagcacagc	9	7	13	12	1	1	2	0	1	1	1	2	4	2	4	3	2	5	3	3	2	1	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:2376444C>T	uc002cpy.1	-	4	736	c.24G>A	c.(22-24)GCG>GCA	p.A8A	ABCA3_uc010bsk.1_Silent_p.A8A|ABCA3_uc010bsl.1_Silent_p.A8A|ABCA3_uc002cpz.1_Silent_p.A8A	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	8					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				AGAGGAGGAGCGCCAGCTGCC	0.602													15	37					0	0	0	0	T	2376444	T	T	2376444	2	4	46	1	0	0	0	0	0	0	0	1	33	755	27	1		1	ABCA3	16	2376444	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08		2376444	87978309	123	9537											
ZNF768	79724	broad.mit.edu	37	chr16	30545603	30545603	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttctcctccacccaggaGatgagcgccggcttgctgcc	5	8	11	17	2	1	2	0	1	1	1	3	3	2	2	6	2	3	2	6	2	0	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:30545603G>C	uc010vex.1	-	2	477	c.-960C>G	c.(-962--958)ATCTC>ATGTC		ZNF747_uc002dyn.2_Missense_Mutation_p.S133C|ZNF747_uc002dyo.1_Missense_Mutation_p.S133C|ZNF747_uc010vey.1_Missense_Mutation_p.S133C|uc002dyp.1_5'Flank	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768						regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						CCACCCAGGAGATGAGCGCCG	0.687													9	14					0	0	0	0	C	30545603	C	C	30545603	1	2	46	1	0	0	0	0	0	0	0	0	18208	942	33	2		2	ZNF768	16	30545603	Translation_Start_Site	SNP	G	TCGA-CN-4735-01A-01D-1434-08	28169159	30545603	59809150	124	9538											
TOX3	27324	broad.mit.edu	37	chr16	52497888	52497888	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcacgccatcttgttccacGagatttcttgagattgtaat	10	14	8	9	2	2	2	0	1	2	2	3	4	3	2	2	0	1	3	2	0	1	6	rs147213203	by1000genomes	TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:52497888G>A	uc002egw.2	-	3	537	c.366C>T	c.(364-366)CTC>CTT	p.L122L	TOX3_uc010vgt.1_Silent_p.L117L|TOX3_uc010vgu.1_Silent_p.L122L	NM_001080430	NP_001073899	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	122					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity				0						CTTGTTCCACGAGATTTCTTG	0.433													58	118					0	0	0	0	A	52497888	A	A	52497888	2	1	46	1	0	0	0	0	0	0	0	1	16446	1045	37	1		1	TOX3	16	52497888	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	21952285	52497888	37856865	125	9539											
HYDIN	54768	broad.mit.edu	37	chr16	70913521	70913521	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttggtacctgggcaagccatCcaaggtagcctcaaagatgc	11	8	11	11	0	1	1	1	0	0	1	2	1	2	1	4	3	4	3	4	3	5	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:70913521C>G	uc002ezr.2	-	61	10479	c.10351G>C	c.(10351-10353)GAT>CAT	p.D3451H		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3452										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GGCAAGCCATCCAAGGTAGCC	0.577													18	83					0	0	0	0	G	70913521	G	G	70913521	3	3	46	1	0	0	0	0	1	0	0	0	7506	855	30	2	5115	2	HYDIN	16	70913521	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	18415633	70913521	19441232	126	9540											
CBFA2T3	863	broad.mit.edu	37	chr16	88968004	88968004	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtgtggaccggggctgcGtcttcacctccgctggggag	3	8	19	11	3	2	0	1	0	1	0	3	2	3	2	3	7	1	2	3	7	0	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr16:88968004G>A	uc002fmm.1	-	2	398	c.212C>T	c.(211-213)ACG>ATG	p.T71M	CBFA2T3_uc002fml.1_Missense_Mutation_p.T10M|CBFA2T3_uc010cif.1_Missense_Mutation_p.T10M|CBFA2T3_uc002fmn.1_Missense_Mutation_p.T71M	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	71	Mediates localization to the nucleus (By similarity).|Pro-rich.|Mediates interaction with PDE7A (in isoform 2).|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CCGGGGCTGCGTCTTCACCTC	0.667			T	RUNX1	AML								23	46					0	0	0	0	A	88968004	A	A	88968004	3	1	46	1	0	0	0	0	1	0	0	0	2710	1145	40	1	1793	1	CBFA2T3	16	88968004	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	18054483	88968004	1386749	127	9541											
TP53	7157	broad.mit.edu	37	chr17	7577570	7577570	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatgcaggaactgttacaCatgtagttgtagtggatggt	10	12	12	7	0	0	0	0	0	0	0	0	2	0	2	1	3	3	5	1	3	4	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:7577570C>T	uc002gim.2	-	7	905	c.711G>A	c.(709-711)ATG>ATA	p.M237I	TP53_uc002gig.1_Missense_Mutation_p.M237I|TP53_uc002gih.2_Missense_Mutation_p.M237I|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.M105I|TP53_uc010cng.1_Missense_Mutation_p.M105I|TP53_uc002gii.1_Missense_Mutation_p.M105I|TP53_uc010cnh.1_Missense_Mutation_p.M237I|TP53_uc010cni.1_Missense_Mutation_p.M237I|TP53_uc002gij.2_Missense_Mutation_p.M237I|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.M144I|TP53_uc002gio.2_Missense_Mutation_p.M105I	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	237	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		M -> L (in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> I (in LFS; germline mutation and in sporadic cancers; somatic mutation).|M -> R (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M237I(99)|p.M237K(8)|p.0?(7)|p.M237V(6)|p.M237fs*10(4)|p.M237R(3)|p.M237T(2)|p.M237L(2)|p.Y236_M237delYM(1)|p.Y236_M237insXX(1)|p.M237_N239delMCN(1)|p.H233fs*6(1)|p.M144I(1)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.M237fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACTGTTACACATGTAGTTGT	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	21					0	0	0	0	T	7577570	T	T	7577570	3	4	46	1	0	0	0	0	1	0	0	0	16448	478	17	4	579	4	TP53	17	7577570	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08		7577570	73617640	128	9542											
MYO18A	399687	broad.mit.edu	37	chr17	27493807	27493807	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcttggattcacgcttggagGagcggttcaggttgaagaag	9	11	15	6	2	3	2	2	1	1	1	3	5	3	5	0	5	1	3	0	5	2	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:27493807G>A	uc002hdt.1	-	2	310	c.152C>T	c.(151-153)TCC>TTC	p.S51F	MYO18A_uc010csa.1_Missense_Mutation_p.S51F|MYO18A_uc002hdu.1_Missense_Mutation_p.S51F	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	51					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ACGCTTGGAGGAGCGGTTCAG	0.517													11	16					0	0	0	0	A	27493807	A	A	27493807	3	1	46	1	0	0	0	0	1	0	0	0	10118	1174	41	2	6176	2	MYO18A	17	27493807	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	19916237	27493807	53701403	129	9543											
HNF1B	6928	broad.mit.edu	37	chr17	36064935	36064935	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacttactttgtgcaattGccatgactccagagaggggt	11	11	11	8	0	0	3	0	1	0	2	1	4	1	3	2	2	4	1	2	2	3	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:36064935G>C	uc002hok.3	-	6	1549	c.1328C>G	c.(1327-1329)GCA>GGA	p.A443G	HNF1B_uc010wdi.1_Missense_Mutation_p.A417G	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	443					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TTGTGCAATTGCCATGACTCC	0.463									Hereditary_Prostate_Cancer				56	141					0	0	0	0	C	36064935	C	C	36064935	3	2	46	1	0	0	0	0	1	0	0	0	7291	1319	46	4	361	4	HNF1B	17	36064935	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	8571128	36064935	45130275	130	9544											
KRT33B	3884	broad.mit.edu	37	chr17	39522833	39522833	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaatcctgcgcaggctgttGatgtcggactccaccagctg	8	9	12	12	2	0	2	0	1	0	1	3	3	2	3	3	2	2	4	3	2	1	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:39522833G>A	uc002hwl.2	-	3	522	c.477C>T	c.(475-477)ATC>ATT	p.I159I		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	159	Rod.|Coil 1B.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				GCAGGCTGTTGATGTCGGACT	0.562													40	82					0	0	0	0	A	39522833	A	A	39522833	2	1	46	1	0	0	0	0	0	0	0	1	8509	1280	45	2		2	KRT33B	17	39522833	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	3457898	39522833	41672377	131	9545											
PPY	5539	broad.mit.edu	37	chr17	42018893	42018893	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcatactgggccatctgctCtggtgtggcattgtcccctg	4	13	12	12	0	2	0	0	0	2	0	3	0	3	0	3	3	3	3	3	3	1	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:42018893C>T	uc002iep.2	-	2	175	c.130G>A	c.(130-132)GAG>AAG	p.E44K		NM_002722	NP_002713	P01298	PAHO_HUMAN	pancreatic polypeptide preproprotein	44					digestion|protein secretion	extracellular region	hormone activity				0		Breast(137;0.00314)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GCCATCTGCTCTGGTGTGGCA	0.607													44	107					0	0	0	0	T	42018893	T	T	42018893	3	4	46	1	0	0	0	0	1	0	0	0	12475	922	32	2	169	2	PPY	17	42018893	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	2496060	42018893	39176317	132	9546											
SCN4A	6329	broad.mit.edu	37	chr17	62034533	62034533	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcactcaccacaagattgcCgatgaccatgaccatgagga	13	7	8	13	1	2	4	2	3	0	1	2	6	2	5	4	1	1	0	4	1	1	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:62034533C>T	uc002jds.1	-	13	2442	c.2365G>A	c.(2365-2367)GGC>AGC	p.G789S		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	789	II.|Helical; Name=S6 of repeat II; (Potential).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	ACAAGATTGCCGATGACCATG	0.582													17	43					0	0	0	0	T	62034533	T	T	62034533	3	4	46	1	0	0	0	0	1	0	0	0	13985	652	23	1	3193	1	SCN4A	17	62034533	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	20015640	62034533	19160677	133	9547											
FBF1	85302	broad.mit.edu	37	chr17	73915956	73915956	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctagcaccttgatgcggcttCtgccaacagaacacccagcc	10	7	8	16	1	1	2	0	1	1	1	1	2	1	2	4	1	6	2	4	1	3	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:73915956C>T	uc002jqc.2	-	19	2161	c.1887_splice	c.e19-1	p.R629_splice	FBF1_uc002jqa.1_Splice_Site|FBF1_uc010wsp.1_Splice_Site_p.R620_splice|FBF1_uc002jqd.1_Splice_Site_p.R630_splice|FBF1_uc002jqb.2_Splice_Site|FBF1_uc010dgr.1_Splice_Site	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1												0						GATGCGGCTTCTGCCAACAGA	0.602													37	57					0	0	0	0	T	73915956	T	T	73915956	5	4	46	1	0	0	0	0	0	0	1	0	5727	927	32	2	1559	2	FBF1	17	73915956	Splice_Site	SNP	C	TCGA-CN-4735-01A-01D-1434-08	11881423	73915956	7279254	134	9548											
AANAT	15	broad.mit.edu	37	chr17	74465350	74465350	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtccctgggctggttcgagGagggctgccttgtggccttc	2	12	16	11	1	0	0	0	0	0	0	3	2	1	1	3	5	1	3	3	5	0	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:74465350G>A	uc002jro.2	+	3	493	c.259G>A	c.(259-261)GAG>AAG	p.E87K	AANAT_uc010wte.1_RNA	NM_001088	NP_001079	Q16613	SNAT_HUMAN	arylalkylamine N-acetyltransferase	87	N-acetyltransferase.				circadian rhythm|melatonin biosynthetic process	cytosol	aralkylamine N-acetyltransferase activity				0						CTGGTTCGAGGAGGGCTGCCT	0.627													113	232					0	0	0	0	A	74465350	A	A	74465350	3	1	46	1	0	0	0	0	1	0	0	0	18	1175	41	2	404	2	AANAT	17	74465350	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	549394	74465350	6729860	135	9549											
SYNGR2	9144	broad.mit.edu	37	chr17	76167595	76167595	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccgtcctcccccagctctCtggaccttcctgtggtttgt	3	13	8	17	1	1	0	0	0	1	0	5	1	4	1	6	2	1	2	6	2	0	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr17:76167595C>T	uc002juu.1	+	3	369	c.342C>T	c.(340-342)CTC>CTT	p.L114L	SYNGR2_uc002jut.2_Silent_p.L114L|SYNGR2_uc002juv.1_Intron|SYNGR2_uc010dhi.1_RNA	NM_004710	NP_004701	O43760	SNG2_HUMAN	synaptogyrin 2	114	MARVEL.|Helical; (Potential).					integral to plasma membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			CCCCAGCTCTCTGGACCTTCC	0.637													34	71					0	0	0	0	T	76167595	T	T	76167595	2	4	46	1	0	0	0	0	0	0	0	1	15515	900	32	2		2	SYNGR2	17	76167595	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	1702245	76167595	5027615	136	9550											
SPIRE1	56907	broad.mit.edu	37	chr18	12453101	12453101	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaggtataagaccaagtgaAgaaggaaaacctcctggttc	16	7	10	8	0	0	3	0	1	0	2	2	4	1	4	3	3	1	2	3	3	7	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr18:12453101A>G	uc002kre.2	-	14	1860	c.1813T>C	c.(1813-1815)TTC>CTC	p.F605L	SPIRE1_uc002krc.2_RNA|SPIRE1_uc010wzw.1_Missense_Mutation_p.F471L|SPIRE1_uc010wzx.1_Missense_Mutation_p.F394L|SPIRE1_uc010wzy.1_Missense_Mutation_p.F591L	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a	605						cytoskeleton|perinuclear region of cytoplasm	actin binding				0						GACCAAGTGAAGAAGGAAAAC	0.328													4	79					0	0	0	0	G	12453101	G	G	12453101	3	3	46	1	0	0	0	0	1	0	0	0	15137	72	3	5	473	5	SPIRE1	18	12453101	Missense_Mutation	SNP	A	TCGA-CN-4735-01A-01D-1434-08		12453101	65624147	137	9551											
NETO1	81832	broad.mit.edu	37	chr18	70461640	70461640	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggtccttaaagtcaggatCttaaaaattgagaaaaagac	19	9	8	5	0	2	2	1	1	1	2	3	4	3	3	1	2	0	0	1	2	8	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr18:70461640C>G	uc002lkw.2	-	5	754	c.470_splice	c.e5-1	p.D157_splice	NETO1_uc002lkx.1_Splice_Site_p.D156_splice|NETO1_uc002lky.1_Splice_Site_p.D157_splice	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3						memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AAGTCAGGATCTTAAAAATTG	0.294													82	61					0	0	0	0	G	70461640	G	G	70461640	5	3	46	1	0	0	0	0	0	0	1	0	10393	927	32	2	1156	2	NETO1	18	70461640	Splice_Site	SNP	C	TCGA-CN-4735-01A-01D-1434-08	58008539	70461640	7615608	138	9552											
FBXO15	201456	broad.mit.edu	37	chr18	71797839	71797839	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttctctactgaattaaatttCcaatttgatcttgcaggtga	11	17	6	7	0	2	3	0	3	2	0	4	3	3	3	1	1	2	1	1	1	5	6			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr18:71797839C>T	uc002lle.2	-	4	495	c.159G>A	c.(157-159)TGG>TGA	p.W53*	FBXO15_uc002llf.2_Nonsense_Mutation_p.W129*	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	53										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		AATTAAATTTCCAATTTGATC	0.348													4	40					0	0	0	0	T	71797839	T	T	71797839	4	4	46	1	0	0	0	0	0	1	0	0	5760	856	30	2	1173	2	FBXO15	18	71797839	Nonsense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	1336199	71797839	6279409	139	9553											
TICAM1	148022	broad.mit.edu	37	chr19	4817884	4817884	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcccagagggcaaagccGaggatggtgggaggcagccc	9	4	18	10	1	0	1	0	0	0	1	1	4	1	3	3	6	2	2	3	6	1	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:4817884G>T	uc002mbi.2	-	2	757	c.506C>A	c.(505-507)TCG>TAG	p.S169*		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	169					apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GGGCAAAGCCGAGGATGGTGG	0.652													7	176					0.00198382	0.00206686	1	0	T	4817884	T	T	4817884	4	4	46	1	0	0	0	0	0	1	0	0	15958	1059	37	3	1636	3	TICAM1	19	4817884	Nonsense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08		4817884	54311099	140	9554											
KANK2	25959	broad.mit.edu	37	chr19	11283762	11283762	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggtgagcataatagggctGtagccagcacggttctgttt	8	11	14	8	2	1	1	0	1	1	0	1	1	1	1	1	3	3	6	1	3	3	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:11283762G>A	uc010dxv.2	-	12	2664	c.2106C>T	c.(2104-2106)TAC>TAT	p.Y702Y	KANK2_uc002mqm.2_Silent_p.Y710Y|KANK2_uc002mqo.3_Silent_p.Y702Y|KANK2_uc002mqp.1_Silent_p.Y511Y	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	702	ANK 2.										0						TAATAGGGCTGTAGCCAGCAC	0.567													77	110					0	0	0	0	A	11283762	A	A	11283762	2	1	46	1	0	0	0	0	0	0	0	1	8016	1372	48	4		4	KANK2	19	11283762	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	6465878	11283762	47845221	141	9555											
MAST1	22983	broad.mit.edu	37	chr19	12976159	12976159	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accccagagtacatcgcgccCgaggtcatcctgcgtcaagg	9	6	11	15	4	2	1	2	0	0	1	4	2	3	1	4	2	2	1	4	2	2	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:12976159C>T	uc002mvm.2	+	15	1796	c.1668C>T	c.(1666-1668)CCC>CCT	p.P556P		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	556	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						ACATCGCGCCCGAGGTCATCC	0.657													64	76					0	0	0	0	T	12976159	T	T	12976159	2	4	46	1	0	0	0	0	0	0	0	1	9377	639	23	1		1	MAST1	19	12976159	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	1692397	12976159	46152824	142	9556											
ZNF253	56242	broad.mit.edu	37	chr19	20003119	20003119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttcacctatcctcacacCttactacacataagatactt	12	13	1	15	0	2	1	2	0	0	1	3	1	3	1	4	0	3	0	4	0	5	7			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:20003119C>T	uc002noj.2	+	4	1155	c.1063C>T	c.(1063-1065)CTT>TTT	p.L355F	ZNF253_uc002nok.2_Missense_Mutation_p.L279F|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	355	C2H2-type 7.			Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATCCTCACACCTTACTACACA	0.388													41	45					0	0	0	0	T	20003119	T	T	20003119	3	4	46	1	0	0	0	0	1	0	0	0	17864	681	24	4	1077	4	ZNF253	19	20003119	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	7026960	20003119	39125864	143	9557											
ZNF714	148206	broad.mit.edu	37	chr19	21300358	21300358	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaaagcttttaaccgattCtcataccttactaaacataa	16	12	3	10	1	1	0	1	0	1	0	2	2	1	0	2	0	5	1	2	0	7	7			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:21300358C>T	uc002npo.3	+	6	1251	c.891C>T	c.(889-891)TTC>TTT	p.F297F	ZNF714_uc002npl.2_Silent_p.F142F|ZNF714_uc010ecp.1_Silent_p.F248F|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	297	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTAACCGATTCTCATACCTTA	0.348													3	17					0	0	0	0	T	21300358	T	T	21300358	2	4	46	1	0	0	0	0	0	0	0	1	18185	912	32	2		2	ZNF714	19	21300358	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	1297239	21300358	37828625	144	9558											
ZNF208	7757	broad.mit.edu	37	chr19	22170088	22170088	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttcctccagaaaaatgatCaggtctggcttaaaggcagc	12	9	9	11	0	2	2	1	1	1	1	4	2	4	2	3	3	1	2	3	3	4	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:22170088C>T	uc002nqp.2	-	3	305	c.156G>A	c.(154-156)CTG>CTA	p.L52L	ZNF208_uc002nqo.1_Silent_p.L52L|ZNF208_uc002nqq.2_RNA	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GAAAAATGATCAGGTCTGGCT	0.398													29	69					0	0	0	0	T	22170088	T	T	22170088	2	4	46	1	0	0	0	0	0	0	0	1	17833	813	29	2		2	ZNF208	19	22170088	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	869730	22170088	36958895	145	9559											
RELB	5971	broad.mit.edu	37	chr19	45528913	45528913	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacatgaatgtggtgaggatCtgcttccaggcctcatatcg	9	11	12	9	1	2	2	1	2	1	0	4	4	3	3	2	3	1	1	2	3	2	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:45528913C>T	uc002paj.1	+	8	930	c.804C>T	c.(802-804)ATC>ATT	p.I268I		NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	268	RHD.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		TGGTGAGGATCTGCTTCCAGG	0.567													93	141					0	0	0	0	T	45528913	T	T	45528913	2	4	46	1	0	0	0	0	0	0	0	1	13282	903	32	2		2	RELB	19	45528913	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	23358825	45528913	13600070	146	9560											
TULP2	7288	broad.mit.edu	37	chr19	49398650	49398650	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccgcggtgtcgggaggcCgcgctcgcccctgccgtctc	1	8	15	17	7	1	0	0	0	1	0	5	1	2	1	5	3	1	1	5	3	0	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:49398650C>T	uc002pkz.2	-	5	473	c.322G>A	c.(322-324)GGC>AGC	p.G108S		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	108					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		GTCGGGAGGCCGCGCTCGCCC	0.488													80	126					0	0	0	0	T	49398650	T	T	49398650	3	4	46	1	0	0	0	0	1	0	0	0	16842	652	23	1	1276	1	TULP2	19	49398650	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	3869737	49398650	9730333	147	9561											
CD33	945	broad.mit.edu	37	chr19	51742808	51742808	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaagttacatggccccacTgaaacctcaagctgttcagg	11	9	8	13	0	2	1	2	1	0	0	3	1	3	1	4	2	3	3	4	2	4	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:51742808T>A	uc002pwa.2	+	7	1000	c.960T>A	c.(958-960)ACT>ACA	p.T320T	CD33_uc010eos.1_3'UTR|CD33_uc010eot.1_Silent_p.T193T|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	320	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	ATGGCCCCACTGAAACCTCAA	0.522													31	50					0	0	0	0	A	51742808	A	A	51742808	2	1	46	1	0	0	0	0	0	0	0	1	3020	1567	55	5		5	CD33	19	51742808	Silent	SNP	T	TCGA-CN-4735-01A-01D-1434-08	2344158	51742808	7386175	148	9562											
ZNF610	162963	broad.mit.edu	37	chr19	52856995	52856995	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aggaggagtggaaatccctgGaccctggacagagggcttta	11	7	15	8	0	0	1	0	0	0	1	1	6	1	6	2	6	0	1	2	6	2	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:52856995G>C	uc002pyx.3	+	4	530	c.124G>C	c.(124-126)GAC>CAC	p.D42H	ZNF610_uc002pyy.3_Missense_Mutation_p.D42H|ZNF610_uc002pyz.3_Missense_Mutation_p.D42H|ZNF610_uc002pza.2_Missense_Mutation_p.D42H	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	42	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GAAATCCCTGGACCCTGGACA	0.493													70	117					0	0	0	0	C	52856995	C	C	52856995	3	2	46	1	0	0	0	0	1	0	0	0	18103	1174	41	2	130	2	ZNF610	19	52856995	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	1114187	52856995	6271988	149	9563											
ZNF880	400713	broad.mit.edu	37	chr19	52887510	52887510	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtcttcagtaacagttcaaAccttgtacaacatcaaagaa	16	10	6	9	0	4	1	3	0	1	1	4	1	4	1	1	1	4	3	1	1	6	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:52887510A>T	uc002pzc.2	+	4	726	c.677A>T	c.(676-678)AAC>ATC	p.N226I		NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	226	C2H2-type 2.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						AACAGTTCAAACCTTGTACAA	0.388													7	22					0	0	0	0	T	52887510	T	T	52887510	3	4	46	1	0	0	0	0	1	0	0	0	18264	43	2	5	691	5	ZNF880	19	52887510	Missense_Mutation	SNP	A	TCGA-CN-4735-01A-01D-1434-08	30515	52887510	6241473	150	9564											
MBOAT7	79143	broad.mit.edu	37	chr19	54692109	54692109	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggcccaggtcccgaggatGgtgaccagagaatgcaaagt	12	5	15	9	1	0	2	0	1	0	1	1	5	1	3	3	4	1	1	3	4	2	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:54692109G>C	uc002qdq.2	-	4	434	c.168C>G	c.(166-168)ACC>ACG	p.T56T	MBOAT7_uc010erg.2_5'Flank|MBOAT7_uc010yem.1_Silent_p.T38T|MBOAT7_uc002qdr.2_Silent_p.T56T|MBOAT7_uc002qds.2_Missense_Mutation_p.H26D|MBOAT7_uc010yen.1_Missense_Mutation_p.H26D|MBOAT7_uc002qdt.3_Silent_p.T56T|TSEN34_uc010yeo.1_5'Flank|TSEN34_uc002qdu.2_5'Flank|TSEN34_uc002qdv.2_5'Flank|TSEN34_uc002qdw.2_5'Flank	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	56	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCCCGAGGATGGTGACCAGAG	0.637													70	108					0	0	0	0	C	54692109	C	C	54692109	2	2	46	1	0	0	0	0	0	0	0	1	9411	1348	47	4		4	MBOAT7	19	54692109	Silent	SNP	G	TCGA-CN-4735-01A-01D-1434-08	1804599	54692109	4436874	151	9565											
BRSK1	84446	broad.mit.edu	37	chr19	55805389	55805389	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctggctgtctcagccacAgagacctaaagcccgagaac	12	5	9	15	1	1	2	1	0	1	2	2	4	1	2	4	1	3	1	4	1	3	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr19:55805389A>G	uc002qkg.2	+	5	740	c.463A>G	c.(463-465)AGA>GGA	p.R155G	BRSK1_uc002qkf.2_Missense_Mutation_p.R171G	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	155	Protein kinase.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		TCTCAGCCACAGAGACCTAAA	0.577													110	229					0	0	0	0	G	55805389	G	G	55805389	3	3	46	1	0	0	0	0	1	0	0	0	1528	180	7	5	481	5	BRSK1	19	55805389	Missense_Mutation	SNP	A	TCGA-CN-4735-01A-01D-1434-08	1113280	55805389	3323594	152	9566											
TRIB3	57761	broad.mit.edu	37	chr20	377164	377164	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcgtcgggagccagctgaaCggctcacagccacaggcatc	9	6	12	14	3	1	1	1	1	0	0	4	2	1	2	2	3	4	3	2	3	1	1	rs139447354		TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:377164C>A	uc002wdm.2	+	4	1413	c.907C>A	c.(907-909)CGG>AGG	p.R303R	TRIB3_uc002wdn.2_Silent_p.R330R	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	303	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GCCAGCTGAACGGCTCACAGC	0.687													69	120					5.26073e-25	5.98174e-25	1	0	A	377164	A	A	377164	2	1	46	1	0	0	0	0	0	0	0	1	16551	527	19	3		3	TRIB3	20	377164	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08		377164	62648356	153	9567											
SNRPB	6628	broad.mit.edu	37	chr20	2443871	2443871	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcttccttgtggggtcatCacctaagaggacataagaag	11	10	10	10	0	3	2	2	0	1	2	4	3	4	3	3	3	0	0	3	3	3	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:2443871C>T	uc002wfz.1	-	5	586	c.423G>A	c.(421-423)GTG>GTA	p.V141V	SNRPB_uc002wga.1_Silent_p.V141V|SNRPB_uc010zpv.1_Silent_p.V62V|SNRPB_uc002wgb.2_Silent_p.V141V|SNORD119_uc010gam.1_5'Flank	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	141					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						GTGGGGTCATCACCTAAGAGG	0.552													8	68					0	0	0	0	T	2443871	T	T	2443871	2	4	46	1	0	0	0	0	0	0	0	1	14925	813	29	2		2	SNRPB	20	2443871	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	2066707	2443871	60581649	154	9568											
C20orf194	25943	broad.mit.edu	37	chr20	3297377	3297377	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaatgacactaaccagccagGagcagaatctgggtacagca	15	5	11	10	0	1	2	0	1	1	1	1	4	1	3	2	2	5	3	2	2	4	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:3297377G>A	uc002wii.2	-	18	1583	c.1532C>T	c.(1531-1533)TCC>TTC	p.S511F	C20orf194_uc002wij.3_Missense_Mutation_p.S250F|C20orf194_uc002wik.2_Missense_Mutation_p.S185F	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	511											0						AACCAGCCAGGAGCAGAATCT	0.527													21	42					0	0	0	0	A	3297377	A	A	3297377	3	1	46	1	0	0	0	0	1	0	0	0	2109	1174	41	2	2081	2	C20orf194	20	3297377	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	853506	3297377	59728143	155	9569											
UQCC	55245	broad.mit.edu	37	chr20	33999835	33999835	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttttctacgtcctccttttgCcggcgaaagactggcaaggg	7	12	11	11	3	1	1	0	0	1	1	3	2	3	1	3	3	2	1	3	3	3	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:33999835C>T	uc002xcd.2	-	1	1	c.-66_splice	c.e1-1		UQCC_uc010zuz.1_Splice_Site|UQCC_uc010zva.1_Splice_Site|UQCC_uc002xce.2_Splice_Site|UQCC_uc002xcg.2_Splice_Site|UQCC_uc010gfb.2_Splice_Site|UQCC_uc010zvb.1_Splice_Site|UQCC_uc002xcf.2_Splice_Site|GDF5_uc010gfc.1_Intron|UQCC_uc010gfd.1_Splice_Site	NM_018244	NP_060714	Q9NVA1	UQCC_HUMAN	basic FGF-repressed Zic binding protein isoform							cytoplasmic membrane-bounded vesicle				breast(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCTCCTTTTGCCGGCGAAAGA	0.597													3	65					0	0	0	0	T	33999835	T	T	33999835	5	4	46	1	0	0	0	0	0	0	1	0	17083	754	26	4		4	UQCC	20	33999835	Splice_Site	SNP	C	TCGA-CN-4735-01A-01D-1434-08	30702458	33999835	29025685	156	9570											
ACTR5	79913	broad.mit.edu	37	chr20	37400305	37400305	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttggatcaccaggaaagagtAtgaagaaaagggaggagagt	17	6	15	3	0	1	4	1	1	0	3	1	8	1	7	1	4	0	1	1	4	5	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:37400305A>T	uc002xjd.2	+	9	1695	c.1670A>T	c.(1669-1671)TAT>TTT	p.Y557F		NM_024855	NP_079131	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog	557					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding				0		Myeloproliferative disorder(115;0.00878)				AGGAAAGAGTATGAAGAAAAG	0.547													59	84					0	0	0	0	T	37400305	T	T	37400305	3	4	46	1	0	0	0	0	1	0	0	0	215	449	16	5	1704	5	ACTR5	20	37400305	Missense_Mutation	SNP	A	TCGA-CN-4735-01A-01D-1434-08	3400470	37400305	25625215	157	9571											
CD40	958	broad.mit.edu	37	chr20	44756820	44756820	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtggtgatccccatcatCttcgggatcctgtttgccat	5	14	10	12	1	2	1	1	1	1	0	5	2	4	2	4	3	1	1	4	3	0	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr20:44756820C>G	uc002xrg.1	+	7	680	c.603C>G	c.(601-603)ATC>ATG	p.I201M	CD40_uc002xrh.1_Missense_Mutation_p.L181V|CD40_uc002xri.1_Missense_Mutation_p.L215V|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA|CD40_uc002xrl.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	201	Helical; (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	TCCCCATCATCTTCGGGATCC	0.567									Immune_Deficiency_with_Hyper-IgM		OREG0025991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	144					0	0	0	0	G	44756820	G	G	44756820	3	3	46	1	0	0	0	0	1	0	0	0	3030	913	32	2	629	2	CD40	20	44756820	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	7356515	44756820	18268700	158	9572											
TMPRSS15	5651	broad.mit.edu	37	chr21	19651350	19651350	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggaaaaacttgattttcttCcggtaaacaaataggttgta	15	13	8	5	1	1	1	0	1	1	0	2	2	2	2	1	3	2	3	1	3	7	8			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:19651350C>T	uc002ykw.2	-	23	2726	c.2695G>A	c.(2695-2697)GAA>AAA	p.E899K		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	899	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TGATTTTCTTCCGGTAAACAA	0.323													32	62					0	0	0	0	T	19651350	T	T	19651350	3	4	46	1	0	0	0	0	1	0	0	0	16312	864	30	2	376	2	TMPRSS15	21	19651350	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08		19651350	28478545	159	9573											
ITSN1	6453	broad.mit.edu	37	chr21	35166729	35166729	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaaacagaaagaacaagaaCgaaagatcatagaattagaa	24	5	8	4	1	1	7	1	1	0	6	1	8	1	7	0	0	3	0	0	0	10	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:35166729C>G	uc002yta.1	+	17	2177	c.1909C>G	c.(1909-1911)CGA>GGA	p.R637G	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.R637G|ITSN1_uc010gmg.2_Missense_Mutation_p.R600G|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.R637G|ITSN1_uc010gmi.2_Missense_Mutation_p.R600G|ITSN1_uc010gmj.2_Missense_Mutation_p.R521G|ITSN1_uc002ysy.2_Missense_Mutation_p.R637G|ITSN1_uc002ysx.2_Missense_Mutation_p.R600G|ITSN1_uc002ytb.1_Missense_Mutation_p.R637G|ITSN1_uc002ytc.1_Missense_Mutation_p.R637G|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.R600G|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.R637G|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.R571G	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	637	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						AGAACAAGAACGAAAGATCAT	0.373													48	84					0	0	0	0	G	35166729	G	G	35166729	3	3	46	1	0	0	0	0	1	0	0	0	7965	528	19	3	1971	3	ITSN1	21	35166729	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	15515379	35166729	12963166	160	9574											
LCA5L	150082	broad.mit.edu	37	chr21	40778524	40778524	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggacttccaaatgtttctCttcccctgataaatctatat	10	17	4	10	0	2	1	0	1	2	0	5	2	4	2	3	1	0	1	3	1	5	7			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:40778524C>T	uc002yxu.2	-	10	1610	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K	LCA5L_uc002yxv.2_Missense_Mutation_p.E433K	NM_152505	NP_689718	O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	433	Potential.										0		Prostate(19;1.2e-06)				AAATGTTTCTCTTCCCCTGAT	0.333													59	132					0	0	0	0	T	40778524	T	T	40778524	3	4	46	1	0	0	0	0	1	0	0	0	8697	922	32	2	719	2	LCA5L	21	40778524	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	5611795	40778524	7351371	161	9575											
PCNT	5116	broad.mit.edu	37	chr21	47851584	47851584	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcgaggccttgctggctcagGagcggagccagctctctgag	6	7	16	12	2	2	1	1	1	1	0	3	4	2	3	2	4	4	3	2	4	0	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:47851584G>T	uc002zji.3	+	38	8313	c.8206G>T	c.(8206-8208)GAG>TAG	p.E2736*	PCNT_uc002zjj.2_Nonsense_Mutation_p.E2618*	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2736	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCTGGCTCAGGAGCGGAGCCA	0.637													18	53					1.56452e-12	1.67681e-12	1	0	T	47851584	T	T	47851584	4	4	46	1	0	0	0	0	0	1	0	0	11644	1175	41	2	8356	2	PCNT	21	47851584	Nonsense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	7073060	47851584	278311	162	9576											
PCNT	5116	broad.mit.edu	37	chr21	47852115	47852115	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtggaggaagtggcagagaGacaaggagaagctggtgaga	15	4	19	3	0	0	4	0	1	0	4	0	9	0	6	0	5	1	2	0	5	3	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr21:47852115G>C	uc002zji.3	+	38	8844	c.8737G>C	c.(8737-8739)GAC>CAC	p.D2913H	PCNT_uc002zjj.2_Intron	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2913	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTGGCAGAGAGACAAGGAGAA	0.602													6	7					0	0	0	0	C	47852115	C	C	47852115	3	2	46	1	0	0	0	0	1	0	0	0	11644	942	33	2	8887	2	PCNT	21	47852115	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	531	47852115	277780	163	9577											
ISX	91464	broad.mit.edu	37	chr22	35481475	35481475	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggacatccactgctctgcGcaggctggctcctcccacga	6	8	11	16	2	1	0	0	0	1	0	4	2	4	1	3	3	2	4	3	3	0	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:35481475G>A	uc003anj.2	+	4	1478	c.527G>A	c.(526-528)CGC>CAC	p.R176H	ISX_uc011amg.1_Missense_Mutation_p.R164H	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	176						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						ACTGCTCTGCGCAGGCTGGCT	0.617													5	261					0	0	0	0	A	35481475	A	A	35481475	3	1	46	1	0	0	0	0	1	0	0	0	7904	1087	38	1	541	1	ISX	22	35481475	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08		35481475	15823091	164	9578											
TNRC6B	23112	broad.mit.edu	37	chr22	40697290	40697290	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acccaacgcattgaatgtggGgctcccagaccttcaaacca	12	7	8	14	1	1	2	1	1	0	1	2	2	2	2	4	2	2	2	4	2	3	2			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:40697290G>A	uc011aor.1	+	15	4284	c.4073G>A	c.(4072-4074)GGG>GAG	p.G1358E	TNRC6B_uc003aym.2_Missense_Mutation_p.G554E|TNRC6B_uc003ayn.3_Missense_Mutation_p.G1248E|TNRC6B_uc003ayo.2_Missense_Mutation_p.G1105E	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	1358					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						TTGAATGTGGGGCTCCCAGAC	0.423													12	17					0	0	0	0	A	40697290	A	A	40697290	3	1	46	1	0	0	0	0	1	0	0	0	16407	1232	43	4	4252	4	TNRC6B	22	40697290	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	5215815	40697290	10607276	165	9579											
TCF20	6942	broad.mit.edu	37	chr22	42610152	42610152	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccagtctgcatgagaggaGatggggtagaactacagctt	11	8	13	9	0	1	3	0	1	1	3	1	5	1	3	2	3	4	3	2	3	3	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chr22:42610152G>A	uc003bcj.1	-	1	1294	c.1160C>T	c.(1159-1161)TCT>TTT	p.S387F	TCF20_uc003bck.1_Missense_Mutation_p.S387F|TCF20_uc003bnt.2_Missense_Mutation_p.S387F	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CATGAGAGGAGATGGGGTAGA	0.512													62	147					0	0	0	0	A	42610152	A	A	42610152	3	1	46	1	0	0	0	0	1	0	0	0	15756	942	33	2	4760	2	TCF20	22	42610152	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	1912862	42610152	8694414	166	9580											
NLGN4X	57502	broad.mit.edu	37	chrX	5821254	5821254	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataggggacctcatcaccatGggccgaatctgcccagctgg	9	7	12	13	1	3	0	2	0	1	0	3	2	3	1	4	4	2	1	4	4	2	1			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:5821254G>T	uc010ndh.2	-	5	1966	c.1465C>A	c.(1465-1467)CAT>AAT	p.H489N	NLGN4X_uc004crp.2_Missense_Mutation_p.H509N|NLGN4X_uc004crq.2_Missense_Mutation_p.H489N|NLGN4X_uc010ndi.2_Missense_Mutation_p.H526N|NLGN4X_uc004crr.2_Missense_Mutation_p.H489N|NLGN4X_uc010ndj.2_Missense_Mutation_p.H489N	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	489	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TCATCACCATGGGCCGAATCT	0.572													51	16					2.14255e-21	2.39966e-21	1	0	T	5821254	T	T	5821254	3	4	46	1	0	0	0	0	1	0	0	0	10518	1348	47	4	993	4	NLGN4X	23	5821254	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08		5821254	149449306	167	9581											
FAM47C	442444	broad.mit.edu	37	chrX	37028587	37028587	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagactggagtgtcccgtCtccacccagagcctcccaag	8	7	10	16	1	1	2	0	1	1	2	4	4	3	3	5	1	1	0	5	1	1	0			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:37028587C>T	uc004ddl.1	+	1	2118	c.2104C>T	c.(2104-2106)CTC>TTC	p.L702F		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	702										ovary(3)	3						AGTGTCCCGTCTCCACCCAGA	0.642													61	33					0	0	0	0	T	37028587	T	T	37028587	3	4	46	1	0	0	0	0	1	0	0	0	5603	913	32	2	2106	2	FAM47C	23	37028587	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	31207333	37028587	118241973	168	9582											
DUSP21	63904	broad.mit.edu	37	chrX	44703874	44703874	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgtttaataacaacaccGtgcgcatgatcaactcgccg	12	9	8	12	4	1	1	1	1	0	0	2	1	1	1	2	0	5	3	2	0	4	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:44703874G>T	uc004dgd.2	+	1	626	c.496G>T	c.(496-498)GTG>TTG	p.V166L		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	166						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						TAACAACACCGTGCGCATGAT	0.507													37	19					7.53189e-24	8.52093e-24	1	0	T	44703874	T	T	44703874	3	4	46	1	0	0	0	0	1	0	0	0	4842	1145	40	3	498	3	DUSP21	23	44703874	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	7675287	44703874	110566686	169	9583											
TBX22	50945	broad.mit.edu	37	chrX	79281105	79281105	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcatgtgttttttcaggtaCgtctatcacagctcacagtg	9	14	9	9	1	4	0	3	0	1	0	4	0	4	0	0	1	3	4	0	1	2	5			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:79281105C>T	uc010nmg.1	+	5	596	c.462C>T	c.(460-462)TAC>TAT	p.Y154Y	TBX22_uc004edi.1_Silent_p.Y34Y|TBX22_uc004edj.1_Silent_p.Y154Y	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	154	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						TTTTCAGGTACGTCTATCACA	0.502													25	23					0	0	0	0	T	79281105	T	T	79281105	2	4	46	1	0	0	0	0	0	0	0	1	15724	547	19	1		1	TBX22	23	79281105	Silent	SNP	C	TCGA-CN-4735-01A-01D-1434-08	34577231	79281105	75989455	170	9584											
PABPC5	140886	broad.mit.edu	37	chrX	90690655	90690656	+	Missense_Mutation	DNP	CC	AA	AA																															tgtacgtgggtgacttggacCcagatgtcaccgaggacatg																										TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:90690655_90690656CC>AA	uc004efg.2	+	2	519_520	c.79_80CC>AA	c.(79-81)CCA>AAA	p.P27K	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	27	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						TGACTTGGACCCAGATGTCACC	0.594													21	7					0	0	0	0	AA	90690656	AA	AA	90690655	3	1	46	1	0	0	0	0	1	0	0	0	11421	623	22	4	81	4	PABPC5	23	90690655	Missense_Mutation	DNP	CC	TCGA-CN-4735-01A-01D-1434-08	11409550	90690655	64579905	171	9585											
CNGA2	1260	broad.mit.edu	37	chrX	150911736	150911736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caaccgcctgctgcactttgCccgcatgtttgagttctttg	5	14	9	13	2	1	1	0	1	1	0	1	1	1	1	3	0	4	5	3	0	1	4			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:150911736C>T	uc004fey.1	+	7	985	c.761C>T	c.(760-762)GCC>GTC	p.A254V		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	254	Extracellular (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCACTTTGCCCGCATGTTT	0.522													4	126					0	0	0	0	T	150911736	T	T	150911736	3	4	46	1	0	0	0	0	1	0	0	0	3612	739	26	4	783	4	CNGA2	23	150911736	Missense_Mutation	SNP	C	TCGA-CN-4735-01A-01D-1434-08	60221081	150911736	4358824	172	9586											
RPL10	6134	broad.mit.edu	37	chrX	153628938	153628938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgattgaggccctgcgcaggGccaagttcaagtttcctggc	7	10	13	11	1	1	2	1	2	0	0	2	2	2	2	3	3	1	3	3	3	2	3			TCGA-CN-4735-01A-01D-1434-08	TCGA-CN-4735-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	369ebdf4-ee27-414d-978d-3698711fae98	e30d9a49-8c83-4451-93ac-fd99ae71b265	g.chrX:153628938G>A	uc004fkm.2	+	6	651	c.463G>A	c.(463-465)GCC>ACC	p.A155T	uc010nuv.1_5'Flank|RPL10_uc004fko.2_Intron|RPL10_uc004fkn.1_Missense_Mutation_p.A155T|RPL10_uc004fkp.1_3'UTR|RPL10_uc004fkq.1_Intron|RPL10_uc004fkr.1_Missense_Mutation_p.A80T	NM_006013	NP_006004	P27635	RL10_HUMAN	ribosomal protein L10	155					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTGCGCAGGGCCAAGTTCAA	0.582													4	114					0	0	0	0	A	153628938	A	A	153628938	3	1	46	1	0	0	0	0	1	0	0	0	13619	1203	42	4	481	4	RPL10	23	153628938	Missense_Mutation	SNP	G	TCGA-CN-4735-01A-01D-1434-08	2717202	153628938	1641622	173	9587											
EPHA10	284656	broad.mit.edu	37	chr1	38184465	38184465	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggaaggtggagaaggcaCggtccgctagtggggtggga	9	5	22	5	2	0	1	0	0	0	1	1	4	1	3	1	9	0	2	1	9	3	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:38184465C>T	uc009vvi.2	-	16	2866	c.2780G>A	c.(2779-2781)CGT>CAT	p.R927H	EPHA10_uc001cbt.2_RNA|EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	927	Cytoplasmic (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGAGAAGGCACGGTCCGCTAG	0.677													8	26					0	0	0	0	T	38184465	T	T	38184465	3	4	47	1	0	0	0	0	1	0	0	0	5190	536	19	1	254	1	EPHA10	1	38184465	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08		38184465	211066156	1	9588											
MACF1	23499	broad.mit.edu	37	chr1	39905138	39905138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaagcccaggcattgatcCttccatcatcaaacaacagg	14	7	8	12	0	2	1	2	1	0	0	4	2	4	2	3	3	3	1	3	3	3	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:39905138C>T	uc010oiu.1	+	37	13873	c.13742C>T	c.(13741-13743)CCT>CTT	p.P4581L	MACF1_uc010ois.1_Missense_Mutation_p.P4079L	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGCATTGATCCTTCCATCATC	0.433													9	62					0	0	0	0	T	39905138	T	T	39905138	3	4	47	1	0	0	0	0	1	0	0	0	9195	681	24	4	18657	4	MACF1	1	39905138	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	1720673	39905138	209345483	2	9589											
PTPRF	5792	broad.mit.edu	37	chr1	44075146	44075146	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctgaccctgtggagatgcGgaggctcaactaccagaccc	9	7	11	14	1	2	3	1	1	1	2	2	5	2	4	3	3	3	1	3	3	2	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:44075146G>A	uc001cjr.2	+	22	4290	c.3950G>A	c.(3949-3951)CGG>CAG	p.R1317Q	PTPRF_uc001cjs.2_Missense_Mutation_p.R1308Q|PTPRF_uc001cju.2_Missense_Mutation_p.R695Q|PTPRF_uc009vwt.2_Missense_Mutation_p.R877Q|PTPRF_uc001cjv.2_Missense_Mutation_p.R777Q|PTPRF_uc001cjw.2_Missense_Mutation_p.R543Q	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1317	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GTGGAGATGCGGAGGCTCAAC	0.602													3	42					0	0	0	0	A	44075146	A	A	44075146	3	1	47	1	0	0	0	0	1	0	0	0	12866	1116	39	1	4028	1	PTPRF	1	44075146	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	4170008	44075146	205175475	3	9590											
ELAVL4	1996	broad.mit.edu	37	chr1	50659453	50659453	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaggtctcatatgcccgtcCgagctctgcctcaatcaggg	7	10	10	14	2	4	0	3	0	2	0	6	1	5	0	3	2	3	1	3	2	3	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:50659453C>T	uc001csb.2	+	4	639	c.371C>T	c.(370-372)CCG>CTG	p.P124L	ELAVL4_uc001cry.3_Missense_Mutation_p.P127L|ELAVL4_uc001crz.3_Missense_Mutation_p.P124L|ELAVL4_uc001csa.3_Missense_Mutation_p.P141L|ELAVL4_uc001csc.3_Missense_Mutation_p.P124L|ELAVL4_uc009vyu.2_Missense_Mutation_p.P129L|ELAVL4_uc010omz.1_Missense_Mutation_p.P129L	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	124	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						TATGCCCGTCCGAGCTCTGCC	0.507													20	113					0	0	0	0	T	50659453	T	T	50659453	3	4	47	1	0	0	0	0	1	0	0	0	5076	652	23	1	484	1	ELAVL4	1	50659453	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	6584307	50659453	198591168	4	9591											
HOOK1	51361	broad.mit.edu	37	chr1	60309254	60309254	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aattacaactagaacaattaCaggaagaaaacttcaggtag	20	8	7	6	0	1	2	1	0	0	2	1	3	1	3	0	2	5	1	0	2	11	5			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:60309254C>T	uc009wad.2	+	10	874	c.772C>T	c.(772-774)CAG>TAG	p.Q258*	HOOK1_uc001czo.2_Nonsense_Mutation_p.Q258*|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Nonsense_Mutation_p.Q216*	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	258	Potential.|Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					AGAACAATTACAGGAAGAAAA	0.328													6	60					0	0	0	0	T	60309254	T	T	60309254	4	4	47	1	0	0	0	0	0	1	0	0	7321	479	17	4	806	4	HOOK1	1	60309254	Nonsense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	9649801	60309254	188941367	5	9592											
MTMR11	10903	broad.mit.edu	37	chr1	149902780	149902780	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaagagcaagaaggaaaaaCtcagagaattcaaaatcagc	21	5	9	6	0	3	4	3	1	0	3	3	6	3	5	0	1	3	1	0	1	8	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:149902780C>T	uc001etl.3	-	14	1619	c.1368G>A	c.(1366-1368)GAG>GAA	p.E456E	SF3B4_uc001etk.1_5'Flank|SF3B4_uc009wll.1_5'Flank|MTMR11_uc001etm.1_Silent_p.E384E|MTMR11_uc010pbm.1_3'UTR|MTMR11_uc010pbn.1_3'UTR	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	456	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GAAGGAAAAACTCAGAGAATT	0.498													4	86					0	0	0	0	T	149902780	T	T	149902780	2	4	47	1	0	0	0	0	0	0	0	1	9993	564	20	4		4	MTMR11	1	149902780	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08	89593526	149902780	99347841	6	9593											
TCHH	7062	broad.mit.edu	37	chr1	152081483	152081495	+	Frame_Shift_Del	DEL	GCTCCTGGCAGCG	-	-																															ctgacgcagctgttgctcgcGctcctggcagcgcagctgct																										TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:152081483_152081495delGCTCCTGGCAGCG	uc001ezp.2	-	2	4198_4210	c.4198_4210delCGCTGCCAGGAGC	c.(4198-4212)CGCTGCCAGGAGCGCfs	p.R1400fs	TCHH_uc009wne.1_Frame_Shift_Del_p.R1400fs	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1400_1404	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding	p.R1400P(1)		ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTTGCTCGCGCTCCTGGCAGCGCAGCTGCTGT	0.577													---	---	---								-	152081495	-	-	152081483	7	5	47	1	0	1	0	1	0	0	0	0	15766	1087	38	0	1625	0	TCHH	1	152081483	Frame_Shift_Del	DEL	GCTCCTGGCAGCG	TCGA-CN-4736-01A-01D-1434-08	2178703	152081483	97169138	7	9594											
OR6K2	81448	broad.mit.edu	37	chr1	158670019	158670019	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acagcaacttaaagtcagttGggtacatagcttgggggtca	12	10	12	7	0	2	0	2	0	0	0	2	0	2	0	0	3	4	4	0	3	5	5			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:158670019G>T	uc001fsu.1	-	1	424	c.424C>A	c.(424-426)CAA>AAA	p.Q142K		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AAAGTCAGTTGGGTACATAGC	0.473													8	60					3.09899e-07	3.64418e-07	1	0	T	158670019	T	T	158670019	3	4	47	1	0	0	0	0	1	0	0	0	11256	1357	47	4	554	4	OR6K2	1	158670019	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	6588536	158670019	90580602	8	9595											
USF1	7391	broad.mit.edu	37	chr1	161011574	161011574	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaagtaagtatagtgcgtCtcagcagctgtcccctccgt	8	10	12	11	2	1	0	1	0	1	0	4	1	3	1	3	1	3	4	3	1	4	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:161011574C>T	uc001fxi.2	-	6	534	c.339G>A	c.(337-339)GAG>GAA	p.E113E	F11R_uc010pjw.1_5'Flank|F11R_uc001fxf.3_5'Flank|TSTD1_uc010pjx.1_5'Flank|TSTD1_uc009wtw.2_5'Flank|TSTD1_uc001fxh.3_5'Flank|USF1_uc001fxj.2_Silent_p.E54E	NM_007122	NP_009053	P22415	USF1_HUMAN	upstream stimulatory factor 1 isoform 1	113					cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TATAGTGCGTCTCAGCAGCTG	0.567											OREG0013936	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	83					0	0	0	0	T	161011574	T	T	161011574	2	4	47	1	0	0	0	0	0	0	0	1	17100	912	32	2		2	USF1	1	161011574	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08	2341555	161011574	88239047	9	9596											
SOX13	9580	broad.mit.edu	37	chr1	204085665	204085665	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcctagcagagaaggagcTccagcttctggtcatgattc	10	9	12	10	0	2	2	1	1	1	1	4	5	3	3	2	2	4	3	2	2	2	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:204085665T>C	uc001ham.2	+	5	1044	c.449T>C	c.(448-450)CTC>CCC	p.L150P	SOX13_uc001hal.2_Missense_Mutation_p.L150P|SOX13_uc010pqp.1_Missense_Mutation_p.L150P|SOX13_uc010pqq.1_Missense_Mutation_p.L17P	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	150					anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			GAGAAGGAGCTCCAGCTTCTG	0.473													19	77					0	0	0	0	C	204085665	C	C	204085665	3	2	47	1	0	0	0	0	1	0	0	0	15008	1551	54	5	463	5	SOX13	1	204085665	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	43074091	204085665	45164956	10	9597											
USH2A	7399	broad.mit.edu	37	chr1	215802185	215802185	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttgtggcccatgatggcttCccacagtgagttgtccatca	7	12	11	11	0	1	2	1	2	0	0	3	2	3	2	3	2	0	3	3	2	0	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr1:215802185C>T	uc001hku.1	-	71	15877	c.15490G>A	c.(15490-15492)GAA>AAA	p.E5164K		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	5164	Cytoplasmic (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATGATGGCTTCCCACAGTGAG	0.493										HNSCC(13;0.011)			9	104					0	0	0	0	T	215802185	T	T	215802185	3	4	47	1	0	0	0	0	1	0	0	0	17104	864	30	2	126	2	USH2A	1	215802185	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	11716520	215802185	33448436	11	9598											
SNTG2	54221	broad.mit.edu	37	chr2	1263157	1263157	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggtgagcacattcgatTgggtgcgagcagaaaggacc	11	7	15	8	2	0	2	0	1	0	1	1	5	0	3	1	3	4	3	1	3	1	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:1263157T>G	uc002qwq.2	+	13	1149	c.1021T>G	c.(1021-1023)TGG>GGG	p.W341G	SNTG2_uc010ewi.2_Missense_Mutation_p.W214G	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	341	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CACATTCGATTGGGTGCGAGC	0.383													12	92					0	0	0	0	G	1263157	G	G	1263157	3	3	47	1	0	0	0	0	1	0	0	0	14939	1812	63	5	1071	5	SNTG2	2	1263157	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08		1263157	241936216	12	9599											
KCNH7	90134	broad.mit.edu	37	chr2	163374452	163374452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtccggatatattcaccaagGgagaacatttgctgggctgt	10	11	12	8	1	1	1	1	0	0	1	2	3	2	2	2	3	2	2	2	3	4	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:163374452G>A	uc002uch.1	-	4	892	c.680C>T	c.(679-681)CCC>CTC	p.P227L	KCNH7_uc002uci.2_Missense_Mutation_p.P227L	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	227	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	ATTCACCAAGGGAGAACATTT	0.483													11	134					0	0	0	0	A	163374452	A	A	163374452	3	1	47	1	0	0	0	0	1	0	0	0	8076	1232	43	4	3028	4	KCNH7	2	163374452	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	162111295	163374452	79824921	13	9600											
FIGN	55137	broad.mit.edu	37	chr2	164467456	164467456	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggtgtcaaaccatggccctGgtaggtgtagccaggaacag	11	7	14	9	0	1	0	1	0	0	0	1	1	1	1	3	5	3	2	3	5	4	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:164467456G>A	uc002uck.1	-	3	1197	c.886C>T	c.(886-888)CAG>TAG	p.Q296*		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	296						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CCATGGCCCTGGTAGGTGTAG	0.577													8	78					0	0	0	0	A	164467456	A	A	164467456	4	1	47	1	0	0	0	0	0	1	0	0	5923	1357	47	4	1397	4	FIGN	2	164467456	Nonsense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	1093004	164467456	78731917	14	9601											
SCN9A	6335	broad.mit.edu	37	chr2	167055551	167055551	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaaggatttgcagacatgaaCctttcttccatctgtgaacg	11	12	9	9	1	2	3	0	2	2	1	3	5	3	4	2	1	3	1	2	1	3	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:167055551C>A	uc010fpl.2	-	27	5906	c.5565G>T	c.(5563-5565)AGG>AGT	p.R1855S	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1866						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CAGACATGAACCTTTCTTCCA	0.443													13	117					0.00136819	0.00148513	1	0	A	167055551	A	A	167055551	3	1	47	1	0	0	0	0	1	0	0	0	13990	506	18	4	372	4	SCN9A	2	167055551	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	2588095	167055551	76143822	15	9602											
TTN	7273	broad.mit.edu	37	chr2	179435645	179435645	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcatatctgtgatcttcaaCtaggccagttacttcaaaat	12	14	5	10	0	5	1	3	1	2	0	5	1	5	1	1	1	2	1	1	1	6	5			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:179435645C>G	uc010zfg.1	-	275	67734	c.67510G>C	c.(67510-67512)GTT>CTT	p.V22504L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V16199L|TTN_uc010zfi.1_Missense_Mutation_p.V16132L|TTN_uc010zfj.1_Missense_Mutation_p.V16007L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23431							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATCTTCAACTAGGCCAGTT	0.418													37	158					0	0	0	0	G	179435645	G	G	179435645	3	3	47	1	0	0	0	0	1	0	0	0	16803	565	20	4	32913	4	TTN	2	179435645	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	12380094	179435645	63763728	16	9603											
NRP2	8828	broad.mit.edu	37	chr2	206628571	206628571	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgggaagccagccaggagAgcaagttgctgtgggtcatc	9	7	16	9	1	1	1	1	0	0	1	2	3	1	2	2	3	5	3	2	3	2	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:206628571A>G	uc002vaw.2	+	13	3009	c.2218A>G	c.(2218-2220)AGC>GGC	p.S740G	NRP2_uc002vau.2_Missense_Mutation_p.S740G|NRP2_uc002vav.2_Missense_Mutation_p.S740G|NRP2_uc002vax.2_Missense_Mutation_p.S740G|NRP2_uc002vay.2_Missense_Mutation_p.S740G	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	740	Extracellular (Potential).|MAM.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CAGCCAGGAGAGCAAGTTGCT	0.677											OREG0015155	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	69					0	0	0	0	G	206628571	G	G	206628571	3	3	47	1	0	0	0	0	1	0	0	0	10715	304	11	5	2295	5	NRP2	2	206628571	Missense_Mutation	SNP	A	TCGA-CN-4736-01A-01D-1434-08	27192926	206628571	36570802	17	9604											
PTPRN	5798	broad.mit.edu	37	chr2	220162103	220162103	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccgtgaaggctccggtggaCcctctgcccggttgaacaag	7	7	13	14	3	1	2	0	2	1	0	2	3	2	3	4	4	2	2	4	4	3	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:220162103C>T	uc002vkz.2	-	14	2029	c.1940G>A	c.(1939-1941)GGT>GAT	p.G647D	PTPRN_uc010zlc.1_Missense_Mutation_p.G557D|PTPRN_uc002vla.2_Missense_Mutation_p.G618D	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	647	Cytoplasmic (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CTCCGGTGGACCCTCTGCCCG	0.632													12	71					0	0	0	0	T	220162103	T	T	220162103	3	4	47	1	0	0	0	0	1	0	0	0	12872	507	18	4	1039	4	PTPRN	2	220162103	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	13533532	220162103	23037270	18	9605											
EPHA4	2043	broad.mit.edu	37	chr2	222429107	222429107	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcatccatgatactcactTcctcccactgcaaagatcca	11	12	3	15	0	2	2	2	1	0	1	6	2	6	2	4	0	2	1	4	0	2	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr2:222429107T>G	uc002vmq.2	-	3	209	c.167A>C	c.(166-168)GAA>GCA	p.E56A	EPHA4_uc002vmr.2_Missense_Mutation_p.E56A|EPHA4_uc010zlm.1_5'UTR|EPHA4_uc010zln.1_Missense_Mutation_p.E56A	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	56	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GATACTCACTTCCTCCCACTG	0.403													30	118					0	0	0	0	G	222429107	G	G	222429107	3	3	47	1	0	0	0	0	1	0	0	0	5193	1783	62	5	2853	5	EPHA4	2	222429107	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	2267004	222429107	20770266	19	9606											
TRANK1	9881	broad.mit.edu	37	chr3	36899181	36899181	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaaccctgggacttgagctGagatgtgtgaccaggggcag	9	8	16	8	0	0	4	0	4	0	1	0	6	0	5	2	3	2	2	2	3	1	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr3:36899181G>A	uc003cgj.2	-	3	552	c.250C>T	c.(250-252)CAG>TAG	p.Q84*		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	634					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GACTTGAGCTGAGATGTGTGA	0.582													23	102					0	0	0	0	A	36899181	A	A	36899181	4	1	47	1	0	0	0	0	0	1	0	0	16521	1299	45	2	6925	2	TRANK1	3	36899181	Nonsense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08		36899181	161123249	20	9607											
ITGA9	3680	broad.mit.edu	37	chr3	37818922	37818922	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	actgctctttccagaaaaacCcaactccctgcatcatccct	11	10	3	17	0	2	1	1	0	1	1	5	1	5	1	4	0	4	2	4	0	3	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr3:37818922C>T	uc003chd.2	+	24	2634	c.2581C>T	c.(2581-2583)CCA>TCA	p.P861S		NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	861	Extracellular (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		CCAGAAAAACCCAACTCCCTG	0.413													8	49					0	0	0	0	T	37818922	T	T	37818922	3	4	47	1	0	0	0	0	1	0	0	0	7922	623	22	4	2675	4	ITGA9	3	37818922	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	919741	37818922	160203508	21	9608											
SCN10A	6336	broad.mit.edu	37	chr3	38793780	38793780	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gttcatcttctccatgcctgGagtcagggttgctgggttga	5	14	13	9	0	4	1	2	1	2	0	5	2	4	2	2	3	2	4	2	3	0	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr3:38793780G>T	uc003ciq.2	-	11	1685	c.1685C>A	c.(1684-1686)TCC>TAC	p.S562Y		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	562					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCCATGCCTGGAGTCAGGGTT	0.607													24	76					7.07758e-08	8.47974e-08	1	0	T	38793780	T	T	38793780	3	4	47	1	0	0	0	0	1	0	0	0	13977	1174	41	2	4253	2	SCN10A	3	38793780	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	974858	38793780	159228650	22	9609											
CRYBG3	131544	broad.mit.edu	37	chr3	97662106	97662106	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caagactcatgtaattgtaaAtcagcccctggagggagaag	14	8	11	8	0	2	2	2	0	0	2	2	4	2	3	2	2	1	2	2	2	5	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr3:97662106A>G	uc003drx.2	+	19	3081	c.3017A>G	c.(3016-3018)AAT>AGT	p.N1006S	CRYBG3_uc010hoz.1_RNA|MINA_uc003dry.1_3'UTR|MINA_uc003drz.1_3'UTR|MINA_uc003dsa.1_3'UTR|MINA_uc003dsb.1_3'UTR|MINA_uc003dsc.1_3'UTR	NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						GTAATTGTAAATCAGCCCCTG	0.308													17	41					0	0	0	0	G	97662106	G	G	97662106	3	3	47	1	0	0	0	0	1	0	0	0	3928	101	4	5	3091	5	CRYBG3	3	97662106	Missense_Mutation	SNP	A	TCGA-CN-4736-01A-01D-1434-08	58868326	97662106	100360324	23	9610											
SLC7A14	57709	broad.mit.edu	37	chr3	170198588	170198588	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttgtctgatttccctatgaGcatctcattgtctcccaagg	7	15	7	12	0	3	2	1	2	3	0	6	2	4	2	2	1	1	1	2	1	2	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr3:170198588G>T	uc003fgz.2	-	7	1799	c.1483C>A	c.(1483-1485)CTC>ATC	p.L495I	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	495						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			TTCCCTATGAGCATCTCATTG	0.498													38	257					2.05212e-20	2.55509e-20	1	0	T	170198588	T	T	170198588	3	4	47	1	0	0	0	0	1	0	0	0	14760	971	34	4	840	4	SLC7A14	3	170198588	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	72536482	170198588	27823842	24	9611											
SEL1L3	23231	broad.mit.edu	37	chr4	25783863	25783863	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtctcaagtcctactcaCttgattccttccaggaactc	8	13	7	13	0	2	1	2	1	1	0	7	2	5	2	3	2	2	0	3	2	3	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr4:25783863C>T	uc003gru.3	-	15	2609	c.2457_splice	c.e15+1	p.Q819_splice	SEL1L3_uc003grv.2_Splice_Site_p.Q226_splice	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3							integral to membrane	binding				0						GTCCTACTCACTTGATTCCTT	0.483													34	167					0	0	0	0	T	25783863	T	T	25783863	5	4	47	1	0	0	0	0	0	0	1	0	14077	579	20	4	980	4	SEL1L3	4	25783863	Splice_Site	SNP	C	TCGA-CN-4736-01A-01D-1434-08		25783863	165370413	25	9612											
TERT	7015	broad.mit.edu	37	chr5	1294259	1294259	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccctgcccaacgggcgtccGctccggctcaggggcagcgc	4	4	14	19	5	1	0	1	0	0	0	3	0	3	0	5	4	3	3	5	4	1	0			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:1294259G>A	uc003jcb.1	-	2	800	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TERT_uc003jca.1_Missense_Mutation_p.R248W|TERT_uc003jcc.1_Missense_Mutation_p.R248W|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	248	Linker.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACGGGCGTCCGCTCCGGCTCA	0.736									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				3	8					0	0	0	0	A	1294259	A	A	1294259	3	1	47	1	0	0	0	0	1	0	0	0	15830	1086	38	1	2716	1	TERT	5	1294259	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08		1294259	179621001	26	9613											
KIAA0947	23379	broad.mit.edu	37	chr5	5461594	5461594	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attgggagcatctaattttaAtgatcagaagagcagtggga	14	11	12	4	0	2	3	1	1	1	2	2	5	2	5	0	2	2	2	0	2	3	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:5461594A>T	uc003jdm.3	+	13	2369	c.2147A>T	c.(2146-2148)AAT>ATT	p.N716I		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	716										ovary(1)|central_nervous_system(1)	2						TCTAATTTTAATGATCAGAAG	0.398													22	36					0	0	0	0	T	5461594	T	T	5461594	3	4	47	1	0	0	0	0	1	0	0	0	8241	101	4	5	2197	5	KIAA0947	5	5461594	Missense_Mutation	SNP	A	TCGA-CN-4736-01A-01D-1434-08	4167335	5461594	175453666	27	9614											
DNAH5	1767	broad.mit.edu	37	chr5	13807734	13807734	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggtggttgcagaagaaaaaTtcagactcttgatcatgtga	13	11	12	5	0	3	5	2	2	1	3	3	5	3	5	0	2	1	2	0	2	3	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:13807734T>A	uc003jfd.2	-	47	7895	c.7853A>T	c.(7852-7854)AAT>ATT	p.N2618I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2618	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGAAGAAAAATTCAGACTCTT	0.388									Kartagener_syndrome				7	24					0	0	0	0	A	13807734	A	A	13807734	3	1	47	1	0	0	0	0	1	0	0	0	4626	1493	52	5	6153	5	DNAH5	5	13807734	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	8346140	13807734	167107526	28	9615											
ANKH	56172	broad.mit.edu	37	chr5	14716935	14716935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgggtgtccaaaacatcaCgaaacagagctggggagaaa	15	6	13	7	1	1	2	1	0	0	2	2	4	2	2	1	3	3	2	1	3	4	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:14716935C>T	uc003jfm.3	-	9	1352	c.1021G>A	c.(1021-1023)GTG>ATG	p.V341M	ANKH_uc003jfl.3_Missense_Mutation_p.V54M	NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	341	Helical; (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						CAAAACATCACGAAACAGAGC	0.453													4	33					0	0	0	0	T	14716935	T	T	14716935	3	4	47	1	0	0	0	0	1	0	0	0	627	536	19	1	473	1	ANKH	5	14716935	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	909201	14716935	166198325	29	9616											
CDH10	1008	broad.mit.edu	37	chr5	24511576	24511576	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgctttgacacttccaaTggctgtgccaactggggagg	8	11	13	9	0	0	1	0	1	0	0	1	2	1	2	2	4	3	3	2	4	2	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:24511576T>A	uc003jgr.1	-	6	1194	c.862A>T	c.(862-864)ATT>TTT	p.I288F	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	288	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ACACTTCCAATGGCTGTGCCA	0.343										HNSCC(23;0.051)			38	72					0	0	0	0	A	24511576	A	A	24511576	3	1	47	1	0	0	0	0	1	0	0	0	3111	1464	51	5	1532	5	CDH10	5	24511576	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	9794641	24511576	156403684	30	9617											
AQPEP	206338	broad.mit.edu	37	chr5	115298653	115298653	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacgatctggagctgtggccGcagctgaggcccgacgagct	7	7	15	12	4	1	1	0	1	1	0	1	5	1	2	2	3	4	4	2	3	1	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:115298653G>A	uc003kro.2	+	1	503	c.339G>A	c.(337-339)CCG>CCA	p.P113P	AQPEP_uc003krp.2_RNA|uc003krn.1_5'UTR	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	113	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						AGCTGTGGCCGCAGCTGAGGC	0.701													6	79					0	0	0	0	A	115298653	A	A	115298653	2	1	47	1	0	0	0	0	0	0	0	1	834	1074	38	1		1	AQPEP	5	115298653	Silent	SNP	G	TCGA-CN-4736-01A-01D-1434-08	90787077	115298653	65616607	31	9618											
PDE6A	5145	broad.mit.edu	37	chr5	149265901	149265901	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcagtgaccatggccaaggCctctaggtccgtgaagtagc	10	7	13	11	1	1	2	0	2	1	0	2	2	2	2	4	3	2	2	4	3	4	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:149265901C>T	uc003lrg.3	-	14	1885	c.1765G>A	c.(1765-1767)GCC>ACC	p.A589T		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	589					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ATGGCCAAGGCCTCTAGGTCC	0.537													10	38					0	0	0	0	T	149265901	T	T	149265901	3	4	47	1	0	0	0	0	1	0	0	0	11699	739	26	4	853	4	PDE6A	5	149265901	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	33967248	149265901	31649359	32	9619											
FAT2	2196	broad.mit.edu	37	chr5	150930202	150930202	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccgaggtccaattttccCaccgttaccaggacaccact	10	8	8	15	2	0	0	0	0	0	0	2	3	2	1	6	2	2	1	6	2	2	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:150930202C>T	uc003lue.3	-	7	4540	c.4527G>A	c.(4525-4527)GTG>GTA	p.V1509V	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1509	Extracellular (Potential).|Cadherin 13.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAATTTTCCCACCGTTACCA	0.522													16	80					0	0	0	0	T	150930202	T	T	150930202	2	4	47	1	0	0	0	0	0	0	0	1	5722	581	21	4		4	FAT2	5	150930202	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08	1664301	150930202	29985058	33	9620											
ADAMTS2	9509	broad.mit.edu	37	chr5	178580593	178580593	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgccggccagtcgtgggCgaaggggtcatccagcaggc	7	4	17	13	4	1	0	1	0	0	0	3	1	2	0	3	5	2	1	3	5	1	0			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr5:178580593C>T	uc003mjw.2	-	9	1414	c.1414G>A	c.(1414-1416)GCC>ACC	p.A472T	ADAMTS2_uc011dgm.1_Missense_Mutation_p.A472T	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	472					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CAGTCGTGGGCGAAGGGGTCA	0.657													5	20					0	0	0	0	T	178580593	T	T	178580593	3	4	47	1	0	0	0	0	1	0	0	0	265	768	27	1	2352	1	ADAMTS2	5	178580593	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	27650391	178580593	2334667	34	9621											
HMGN4	10473	broad.mit.edu	37	chr6	26545528	26545528	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagctcggttgtctgctaaaCcagctcctccaaaaccagag	11	8	8	14	1	1	1	0	0	1	1	4	1	3	1	4	1	5	4	4	1	4	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr6:26545528C>T	uc003nig.2	+	2	332	c.94C>T	c.(94-96)CCA>TCA	p.P32S		NM_006353	NP_006344	O00479	HMGN4_HUMAN	high mobility group nucleosomal binding domain	32						chromatin|nucleus	DNA binding				0						GTCTGCTAAACCAGCTCCTCC	0.502													15	48					0	0	0	0	T	26545528	T	T	26545528	3	4	47	1	0	0	0	0	1	0	0	0	7276	507	18	4	96	4	HMGN4	6	26545528	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08		26545528	144569539	35	9622											
GLCCI1	113263	broad.mit.edu	37	chr7	8110681	8110681	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagcagtcattcaccctGtgtctcccctttttgtcccc	4	14	6	17	0	3	0	2	0	1	0	5	0	4	0	5	0	2	2	5	0	0	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:8110681G>T	uc003srk.2	+	6	1656	c.1097G>T	c.(1096-1098)TGT>TTT	p.C366F		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	366											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		CATTCACCCTGTGTCTCCCCT	0.512													68	167					2.48295e-43	3.15335e-43	1	0	T	8110681	T	T	8110681	3	4	47	1	0	0	0	0	1	0	0	0	6468	1377	48	4	1119	4	GLCCI1	7	8110681	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08		8110681	151027982	36	9623											
NPC1L1	29881	broad.mit.edu	37	chr7	44560609	44560609	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accctttgggacatttgatgTtgggccggtcgttcaggaac	7	12	13	9	2	1	1	1	1	0	0	2	3	1	3	2	4	1	2	2	4	1	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:44560609T>C	uc003tlb.2	-	13	3118	c.3062A>G	c.(3061-3063)AAC>AGC	p.N1021S	NPC1L1_uc003tlc.2_Missense_Mutation_p.N1021S|NPC1L1_uc011kbw.1_Missense_Mutation_p.N975S|NPC1L1_uc003tla.2_Missense_Mutation_p.N24S	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1021	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	ACATTTGATGTTGGGCCGGTC	0.547													50	264					0	0	0	0	C	44560609	C	C	44560609	3	2	47	1	0	0	0	0	1	0	0	0	10625	1725	60	5	1049	5	NPC1L1	7	44560609	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	36449928	44560609	114578054	37	9624											
PION	54103	broad.mit.edu	37	chr7	76984548	76984548	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctgggcttccaggaactgCgcaccttgaccgcagtagag	9	7	12	13	2	0	2	0	1	0	1	1	3	1	3	4	2	2	4	4	2	2	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:76984548C>A	uc003ugf.2	-	16	1399	c.1320G>T	c.(1318-1320)GCG>GCT	p.A440A	PION_uc003ugg.1_Silent_p.A225A	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	440					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						CCAGGAACTGCGCACCTTGAC	0.473													13	75					5.50884e-06	6.19135e-06	1	0	A	76984548	A	A	76984548	2	1	47	1	0	0	0	0	0	0	0	1	11989	755	27	3		3	PION	7	76984548	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08	32423939	76984548	82154115	38	9625											
CYP51A1	1595	broad.mit.edu	37	chr7	91756928	91756928	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggccactttttaacattttCttctgctccaagaaaacctt	11	15	4	11	0	2	1	0	0	2	1	3	1	3	1	3	1	3	1	3	1	4	7			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:91756928C>T	uc003ulm.3	-	4	648	c.486G>A	c.(484-486)AAG>AAA	p.K162K	CYP51A1_uc011khn.1_Silent_p.K57K|CYP51A1_uc003uln.3_Silent_p.K99K	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	156					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	TTAACATTTTCTTCTGCTCCA	0.303													4	53					0	0	0	0	T	91756928	T	T	91756928	2	4	47	1	0	0	0	0	0	0	0	1	4212	912	32	2		2	CYP51A1	7	91756928	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08	14772380	91756928	67381735	39	9626											
ZC3HC1	51530	broad.mit.edu	37	chr7	129679338	129679338	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctggccagaaacagaacttCtcatgggcagtacacaaggc	13	7	10	11	0	2	2	1	0	2	2	3	2	2	2	1	3	3	2	1	3	4	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:129679338C>T	uc003vpi.2	-	4	486	c.459G>A	c.(457-459)GAG>GAA	p.E153E	ZC3HC1_uc003vph.2_Silent_p.E40E|ZC3HC1_uc010lma.2_Silent_p.E40E	NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	153	C3HC-type.				cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					AACAGAACTTCTCATGGGCAG	0.388													5	60					0	0	0	0	T	129679338	T	T	129679338	2	4	47	1	0	0	0	0	0	0	0	1	17644	912	32	2		2	ZC3HC1	7	129679338	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08	37922410	129679338	29459325	40	9627											
DPP6	1804	broad.mit.edu	37	chr7	154672633	154672633	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtacattgacaggacgcGcgtggccgtgtttgggaagg	8	8	17	8	4	0	1	0	1	0	0	0	3	0	3	1	4	1	3	1	4	2	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr7:154672633G>A	uc003wlk.2	+	21	2243	c.2114G>A	c.(2113-2115)CGC>CAC	p.R705H	DPP6_uc003wli.2_Missense_Mutation_p.R641H|DPP6_uc003wlm.2_Missense_Mutation_p.R643H|DPP6_uc011kvq.1_Missense_Mutation_p.R598H	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	705	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GACAGGACGCGCGTGGCCGTG	0.552													8	68					0	0	0	0	A	154672633	A	A	154672633	3	1	47	1	0	0	0	0	1	0	0	0	4752	1087	38	1	2312	1	DPP6	7	154672633	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	24993295	154672633	4466030	41	9628											
LONRF1	91694	broad.mit.edu	37	chr8	12594431	12594431	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgttttttcagcttattTcttccatcttcatttacaat	7	22	2	10	0	4	0	2	0	2	0	5	0	5	0	2	0	2	2	2	0	3	10			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr8:12594431T>A	uc003wwd.1	-	5	1395	c.1332A>T	c.(1330-1332)AGA>AGT	p.R444S	LONRF1_uc011kxv.1_Missense_Mutation_p.R44S|LONRF1_uc010lsp.1_Missense_Mutation_p.R44S	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	444					proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		TCAGCTTATTTCTTCCATCTT	0.308													9	28					0	0	0	0	A	12594431	A	A	12594431	3	1	47	1	0	0	0	0	1	0	0	0	8944	1780	62	5	1021	5	LONRF1	8	12594431	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08		12594431	133769591	42	9629											
ARFGEF1	10565	broad.mit.edu	37	chr8	68151121	68151121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcctggacatatgcatctCtctccagctataaaaaagag	13	10	8	10	0	2	1	0	0	2	1	4	2	2	2	2	1	3	2	2	1	5	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr8:68151121C>T	uc003xxo.1	-	21	3377	c.2987G>A	c.(2986-2988)AGA>AAA	p.R996K	ARFGEF1_uc003xxl.1_Missense_Mutation_p.R450K|ARFGEF1_uc003xxn.1_5'UTR	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	996					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ATATGCATCTCTCTCCAGCTA	0.358													16	66					0	0	0	0	T	68151121	T	T	68151121	3	4	47	1	0	0	0	0	1	0	0	0	852	913	32	2	2638	2	ARFGEF1	8	68151121	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	55556690	68151121	78212901	43	9630											
MMP16	4325	broad.mit.edu	37	chr8	89180109	89180109	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtagggaacttcttcaaaTgtcagaggagttacattctg	11	13	10	7	0	4	1	2	0	2	1	4	3	4	3	0	2	2	2	0	2	4	5	rs144277355		TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr8:89180109T>A	uc003yeb.3	-	4	780	c.498A>T	c.(496-498)ACA>ACT	p.T166T	MMP16_uc003yec.2_Silent_p.T166T	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	166	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						CTTCTTCAAATGTCAGAGGAG	0.423													9	79					0	0	0	0	A	89180109	A	A	89180109	2	1	47	1	0	0	0	0	0	0	0	1	9708	1451	51	5		5	MMP16	8	89180109	Silent	SNP	T	TCGA-CN-4736-01A-01D-1434-08	21028988	89180109	57183913	44	9631											
RIMS2	9699	broad.mit.edu	37	chr8	105161040	105161040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagctatcgttggtctgtcaCggaaaagtcgcagtgcttct	8	13	11	9	3	3	0	1	0	2	0	5	1	3	1	0	2	2	4	0	2	4	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr8:105161040C>T	uc003yls.2	+	23	3593	c.3352C>T	c.(3352-3354)CGG>TGG	p.R1118W	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.R1107W|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1157					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGGTCTGTCACGGAAAAGTCG	0.463										HNSCC(12;0.0054)			20	104					0	0	0	0	T	105161040	T	T	105161040	3	4	47	1	0	0	0	0	1	0	0	0	13433	551	19	1		1	RIMS2	8	105161040	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	15980931	105161040	41202982	45	9632											
PSIP1	11168	broad.mit.edu	37	chr9	15465561	15465561	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagagatatttcagtctctCtctcttcactggatggcctg	7	15	8	11	0	6	1	3	0	3	1	8	3	6	2	1	2	0	0	1	2	1	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr9:15465561C>G	uc003zlv.3	-	16	1880	c.1550G>C	c.(1549-1551)AGA>ACA	p.R517T	PSIP1_uc003zlw.3_Missense_Mutation_p.R517T|SNAPC3_uc003zlu.2_RNA	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	517					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TTCAGTCTCTCTCTCTTCACT	0.363													24	148					0	0	0	0	G	15465561	G	G	15465561	3	3	47	1	0	0	0	0	1	0	0	0	12725	913	32	2	46	2	PSIP1	9	15465561	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08		15465561	125747870	46	9633											
CDKN2A	1029	broad.mit.edu	37	chr9	21971000	21971000	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacatcgcgatggcccagctCctcagccaggtccacgggca	8	5	12	16	3	1	0	1	0	0	0	4	2	3	0	4	3	2	2	4	3	0	0			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr9:21971000C>A	uc003zpk.2	-	2	570	c.358G>T	c.(358-360)GAG>TAG	p.E120*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	120	ANK 4.		E -> A (in non-small cell lung carcinoma).|E -> K (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E120*(8)|p.E120K(4)|p.E120A(1)|p.A118fs*10(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGGCCCAGCTCCTCAGCCAGG	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			21	31					1.87028e-06	2.15933e-06	1	0	A	21971000	A	A	21971000	4	1	47	1	0	0	0	0	0	1	0	0	3176	864	30	2	120	2	CDKN2A	9	21971000	Nonsense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	6505439	21971000	119242431	47	9634											
ZNF658	26149	broad.mit.edu	37	chr9	40773300	40773300	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcccacattcattacattCatagggtttctcccctgtgt	7	16	5	13	0	4	0	2	0	2	0	6	0	4	0	3	1	1	1	3	1	2	5			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr9:40773300C>T	uc004abs.2	-	5	2127	c.1975G>A	c.(1975-1977)GAA>AAA	p.E659K	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.E659K	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	659	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCATTACATTCATAGGGTTTC	0.418													70	266					0	0	0	0	T	40773300	T	T	40773300	3	4	47	1	0	0	0	0	1	0	0	0	18136	835	29	2	1208	2	ZNF658	9	40773300	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	18802300	40773300	100440131	48	9635											
NOTCH1	4851	broad.mit.edu	37	chr9	139412213	139412213	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgacgcaccgggcatgcAgatgcactggaactccccaa	10	4	12	15	3	0	1	0	0	0	1	1	3	1	2	4	3	3	4	4	3	2	0			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr9:139412213A>T	uc004chz.2	-	8	1432	c.1432T>A	c.(1432-1434)TGC>AGC	p.C478S		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	478	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCGGGCATGCAGATGCACTGG	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			10	70					0	0	0	0	T	139412213	T	T	139412213	3	4	47	1	0	0	0	0	1	0	0	0	10601	188	7	5	6343	5	NOTCH1	9	139412213	Missense_Mutation	SNP	A	TCGA-CN-4736-01A-01D-1434-08	98638913	139412213	1801218	49	9636											
MLLT10	8028	broad.mit.edu	37	chr10	21959517	21959517	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agatgtttcagagactagagGgtcagagggcaaagggaaga	15	6	16	4	0	2	5	2	0	0	5	2	7	2	6	0	3	0	2	0	3	3	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr10:21959517G>C	uc001iqs.2	+	10	1283	c.935G>C	c.(934-936)GGG>GCG	p.G312A	MLLT10_uc001iqt.2_Missense_Mutation_p.G312A|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.G312A|MLLT10_uc001ira.2_5'UTR|MLLT10_uc001iqz.2_Missense_Mutation_p.G67A	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	312	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						GAGACTAGAGGGTCAGAGGGC	0.468			T	MLL|PICALM|CDK6	AL								6	45					0	0	0	0	C	21959517	C	C	21959517	3	2	47	1	0	0	0	0	1	0	0	0	9679	1232	43	4	969	4	MLLT10	10	21959517	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08		21959517	113575230	50	9637											
OR52A4	390053	broad.mit.edu	37	chr11	5142407	5142407	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaatactatagcacgcctCagaggataacagatcgctac	14	8	9	10	2	1	3	1	1	0	2	2	4	1	4	1	1	4	2	1	1	6	5			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:5142407C>A	uc001lzz.1	-	1	402	c.402G>T	c.(400-402)CTG>CTT	p.L134L	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TAGCACGCCTCAGAGGATAAC	0.473													7	35					0.00198382	0.00213513	1	0	A	5142407	A	A	5142407	2	1	47	1	0	0	0	0	0	0	0	1	11163	813	29	2		2	OR52A4	11	5142407	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08		5142407	129864109	51	9638											
E2F8	79733	broad.mit.edu	37	chr11	19252273	19252273	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgataagagatgggtgtcgaGtaaagtttggtttcccacgt	10	13	13	5	2	0	2	0	1	0	1	2	4	1	2	1	2	0	3	1	2	3	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:19252273G>A	uc001mpm.2	-	8	1697	c.1175C>T	c.(1174-1176)ACT>ATT	p.T392I	E2F8_uc009yhv.2_Intron|E2F8_uc001mpn.3_Missense_Mutation_p.T392I	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	392					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TGGGTGTCGAGTAAAGTTTGG	0.423													18	84					0	0	0	0	A	19252273	A	A	19252273	3	1	47	1	0	0	0	0	1	0	0	0	4895	1029	36	4	1452	4	E2F8	11	19252273	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	14109866	19252273	115754243	52	9639											
OR5M1	390168	broad.mit.edu	37	chr11	56380079	56380079	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccctaatcatttgttgcatGgcaaggattacatctgtgtt	9	15	8	9	0	2	0	1	0	1	0	2	1	2	1	2	2	2	4	2	2	3	5			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:56380079G>A	uc001nja.1	-	1	900	c.900C>T	c.(898-900)GCC>GCT	p.A300A		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TTTGTTGCATGGCAAGGATTA	0.388													37	190					0	0	0	0	A	56380079	A	A	56380079	2	1	47	1	0	0	0	0	0	0	0	1	11226	1335	47	4		4	OR5M1	11	56380079	Silent	SNP	G	TCGA-CN-4736-01A-01D-1434-08	37127806	56380079	78626437	53	9640											
OR5B2	390190	broad.mit.edu	37	chr11	58189994	58189994	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attactgtcccatagaagacGgagactgcagtgaagtgaga	14	8	12	7	1	0	5	0	2	0	4	1	7	1	5	1	1	2	1	1	1	4	2	rs150284257		TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:58189994G>T	uc010rkg.1	-	1	741	c.741C>A	c.(739-741)TCC>TCA	p.S247S		NM_001005566	NP_001005566	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CATAGAAGACGGAGACTGCAG	0.463													9	46					0.000274275	0.000302895	1	0	T	58189994	T	T	58189994	2	4	47	1	0	0	0	0	0	0	0	1	11204	1103	39	3		3	OR5B2	11	58189994	Silent	SNP	G	TCGA-CN-4736-01A-01D-1434-08	1809915	58189994	76816522	54	9641											
BRMS1	25855	broad.mit.edu	37	chr11	66109064	66109064	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcactgacacactcgctgCggcgtcgctcatagtcctca	7	10	8	16	4	3	1	3	1	1	0	7	1	4	1	1	1	1	2	1	1	1	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:66109064C>T	uc001ohp.1	-	3	317	c.170G>A	c.(169-171)CGC>CAC	p.R57H	BRMS1_uc001oho.1_Missense_Mutation_p.R57H|BRMS1_uc009yre.2_5'Flank	NM_015399	NP_056214	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1 isoform 1	57					apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding				0						ACACTCGCTGCGGCGTCGCTC	0.542													5	278					0	0	0	0	T	66109064	T	T	66109064	3	4	47	1	0	0	0	0	1	0	0	0	1521	768	27	1	746	1	BRMS1	11	66109064	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	7919070	66109064	68897452	55	9642											
FAM55B	120406	broad.mit.edu	37	chr11	114569215	114569215	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccctgtctctgctgctcaTccaccccagtgaaggggtat	6	12	9	14	0	2	1	1	1	1	0	5	1	4	1	4	2	2	3	4	2	2	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr11:114569215T>A	uc009yyy.2	+	3	679	c.581T>A	c.(580-582)ATC>AAC	p.I194N		NM_182495	NP_872301	Q96DL1	FA55B_HUMAN	hypothetical protein LOC120406	194						integral to membrane				ovary(1)	1						CTGCTGCTCATCCACCCCAGT	0.542													4	27					0	0	0	0	A	114569215	A	A	114569215	3	1	47	1	0	0	0	0	1	0	0	0	5617	1435	50	5	591	5	FAM55B	11	114569215	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	48460151	114569215	20437301	56	9643											
WNK1	65125	broad.mit.edu	37	chr12	971429	971429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatggggtatatccaccctCaagtgtggtaagtaaatgct	11	11	10	9	0	1	0	1	0	0	0	2	0	2	0	3	3	1	4	3	3	6	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:971429C>T	uc001qio.3	+	8	2639	c.2132C>T	c.(2131-2133)TCA>TTA	p.S711L	WNK1_uc001qip.3_Missense_Mutation_p.S711L|WNK1_uc001qir.3_Missense_Mutation_p.S158L	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	711					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TATCCACCCTCAAGTGTGGTA	0.428													17	53					0	0	0	0	T	971429	T	T	971429	3	4	47	1	0	0	0	0	1	0	0	0	17445	838	29	2	2162	2	WNK1	12	971429	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08		971429	132880466	57	9644											
ADIPOR2	79602	broad.mit.edu	37	chr12	1889793	1889793	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcagagggggtctctcggCtcttctctaagtaagtatct	8	13	10	10	1	5	1	1	0	4	1	8	1	5	1	0	3	0	3	0	3	3	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:1889793C>T	uc001qjm.2	+	5	837	c.640C>T	c.(640-642)CTC>TTC	p.L214F	ADIPOR2_uc001qjn.2_Missense_Mutation_p.L214F	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	214	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)			GGTCTCTCGGCTCTTCTCTAA	0.428													54	258					0	0	0	0	T	1889793	T	T	1889793	3	4	47	1	0	0	0	0	1	0	0	0	319	797	28	4	654	4	ADIPOR2	12	1889793	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	918364	1889793	131962102	58	9645											
EFCAB4B	84766	broad.mit.edu	37	chr12	3788183	3788183	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctcatcccctctggacagaTacaccttctcttcatggcgc	7	11	6	17	1	4	1	2	0	2	1	6	2	5	2	4	2	1	0	4	2	1	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:3788183T>A	uc001qmj.2	-	6	994	c.422A>T	c.(421-423)TAT>TTT	p.Y141F	EFCAB4B_uc010sen.1_Missense_Mutation_p.Y141F|EFCAB4B_uc010seo.1_Missense_Mutation_p.Y141F	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	141					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TCTGGACAGATACACCTTCTC	0.557													13	110					0	0	0	0	A	3788183	A	A	3788183	3	1	47	1	0	0	0	0	1	0	0	0	4959	1406	49	5	2025	5	EFCAB4B	12	3788183	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	1898390	3788183	130063712	59	9646											
PLBD1	79887	broad.mit.edu	37	chr12	14659876	14659876	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgctacgtactgttgtatcGcatgatatatttcatggatg	10	16	9	6	2	1	1	1	1	0	0	2	2	1	2	0	1	3	5	0	1	5	7	rs145582746		TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:14659876G>A	uc001rcc.1	-	9	1524	c.1363C>T	c.(1363-1365)CGA>TGA	p.R455*		NM_024829	NP_079105	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	455					lipid catabolic process	extracellular region	hydrolase activity				0						CTGTTGTATCGCATGATATAT	0.403													23	112					0	0	0	0	A	14659876	A	A	14659876	4	1	47	1	0	0	0	0	0	1	0	0	12080	1095	38	1	310	1	PLBD1	12	14659876	Nonsense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	10871693	14659876	119192019	60	9647											
NCKAP1L	3071	broad.mit.edu	37	chr12	54891638	54891638	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cactatcctgaatgatcgcgGtcagggggttctcatccgta	8	11	11	11	3	2	2	2	2	1	0	6	2	4	2	2	3	0	2	2	3	3	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:54891638G>T	uc001sgc.3	+	1	144	c.65G>T	c.(64-66)GGT>GTT	p.G22V	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_5'Flank	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	22					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						AATGATCGCGGTCAGGGGGTT	0.453													5	52					1.23904e-05	1.38033e-05	1	0	T	54891638	T	T	54891638	3	4	47	1	0	0	0	0	1	0	0	0	10276	1261	44	4	67	4	NCKAP1L	12	54891638	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	40231762	54891638	78960257	61	9648											
MON2	23041	broad.mit.edu	37	chr12	62954394	62954394	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aattttacagattgtgtcccCtgtcagagactcagataagc	12	12	8	9	0	2	3	2	0	0	3	3	4	3	3	2	0	2	0	2	0	3	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:62954394C>A	uc001sre.2	+	26	3924	c.3533C>A	c.(3532-3534)CCT>CAT	p.P1178H	MON2_uc009zqj.2_Missense_Mutation_p.P1178H|MON2_uc010ssl.1_Missense_Mutation_p.P1106H|MON2_uc010ssm.1_Missense_Mutation_p.P1155H|MON2_uc010ssn.1_Missense_Mutation_p.P1178H|MON2_uc001srf.2_Missense_Mutation_p.P941H|MON2_uc001srg.2_Missense_Mutation_p.P53H	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1179					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		ATTGTGTCCCCTGTCAGAGAC	0.448													11	71					0.000673444	0.000737305	1	0	A	62954394	A	A	62954394	3	1	47	1	0	0	0	0	1	0	0	0	9753	681	24	4	3635	4	MON2	12	62954394	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	8062756	62954394	70897501	62	9649											
TSPAN8	7103	broad.mit.edu	37	chr12	71531971	71531971	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agctcctaggatacctgtcgCcacctgcaggagcaggatca	10	7	11	13	1	1	0	1	0	0	0	3	3	2	3	4	3	4	3	4	3	2	2	rs140330026	by1000genomes	TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:71531971C>A	uc009zrt.1	-	4	463	c.301G>T	c.(301-303)GCG>TCG	p.A101S	TSPAN8_uc001swk.1_Missense_Mutation_p.A101S|TSPAN8_uc001swj.1_Missense_Mutation_p.A101S	NM_004616	NP_004607	P19075	TSN8_HUMAN	transmembrane 4 superfamily member 3	101	Helical; (Potential).				protein glycosylation	integral to membrane|lysosome	signal transducer activity			skin(2)|lung(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			ATACCTGTCGCCACCTGCAGG	0.393													28	144					1.32181e-22	1.66208e-22	1	0	A	71531971	A	A	71531971	3	1	47	1	0	0	0	0	1	0	0	0	16720	739	26	4	432	4	TSPAN8	12	71531971	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	8577577	71531971	62319924	63	9650											
SCARB1	949	broad.mit.edu	37	chr12	125270878	125270878	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagcgaatggctgtcagcccGggctgccctctggccagcac	7	6	13	15	2	2	0	1	0	1	0	2	1	2	0	3	3	4	3	3	3	2	0			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr12:125270878G>A	uc001ugo.3	-	11	1679	c.1426C>T	c.(1426-1428)CGG>TGG	p.R476W	SCARB1_uc001ugn.3_Intron|SCARB1_uc001ugm.3_Intron|SCARB1_uc010tbd.1_Intron|SCARB1_uc010tbe.1_Missense_Mutation_p.R435W|SCARB1_uc001ugp.3_Missense_Mutation_p.R476W	NM_005505	NP_005496	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1 isoform 1	476	Cytoplasmic (Potential).				adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			kidney(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	CTGTCAGCCCGGGCTGCCCTC	0.667													26	126					0	0	0	0	A	125270878	A	A	125270878	3	1	47	1	0	0	0	0	1	0	0	0	13946	1131	39	1		1	SCARB1	12	125270878	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	53738907	125270878	8581017	64	9651											
TPTE2	93492	broad.mit.edu	37	chr13	20000607	20000607	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcatcatacagaggtggAccgtcatatacattaattaa	16	11	6	8	1	3	1	3	0	0	1	3	2	3	2	1	2	2	0	1	2	5	5			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr13:20000607A>G	uc001umd.2	-	19	1564	c.1353T>C	c.(1351-1353)GGT>GGC	p.G451G	TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Silent_p.G340G|TPTE2_uc001ume.2_Silent_p.G374G|TPTE2_uc009zzm.2_Silent_p.G122G|TPTE2_uc010tcm.1_RNA|TPTE2_uc010tcl.1_Silent_p.G122G	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	451	C2 tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ACAGAGGTGGACCGTCATATA	0.338													24	88					0	0	0	0	G	20000607	G	G	20000607	2	3	47	1	0	0	0	0	0	0	0	1	16498	262	10	5		5	TPTE2	13	20000607	Silent	SNP	A	TCGA-CN-4736-01A-01D-1434-08		20000607	95169271	65	9652											
ZMYM5	9205	broad.mit.edu	37	chr13	20399104	20399104	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtacaatggagtcttcaaaaTttttctcttccagttgctct	9	17	6	9	0	4	0	1	0	3	0	6	1	5	1	1	1	2	3	1	1	4	6			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr13:20399104T>G	uc010tcn.1	-	8	1788	c.1523A>C	c.(1522-1524)AAT>ACT	p.N508T	ZMYM5_uc001umm.1_Missense_Mutation_p.N332T	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	508						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		gtcttcaaaatttttctcttc	0													2	14					0	0	0	0	G	20399104	G	G	20399104	3	3	47	1	0	0	0	0	1	0	0	0	17770	1493	52	5	490	5	ZMYM5	13	20399104	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	398497	20399104	94770774	66	9653											
LCP1	3936	broad.mit.edu	37	chr13	46725072	46725072	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaacaacgctcctcctaccTtgatgtcagtactgaagttg	11	11	7	12	1	1	2	1	2	0	0	3	2	3	2	3	0	4	3	3	0	5	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr13:46725072T>C	uc001vaz.3	-	8	1007	c.881A>G	c.(880-882)AAG>AGG	p.K294R	LCP1_uc001vba.3_Missense_Mutation_p.K294R	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	294	CH 2.|Actin-binding 1.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TCCTCCTACCTTGATGTCAGT	0.448			T	BCL6	NHL 								51	99					0	0	0	0	C	46725072	C	C	46725072	3	2	47	1	0	0	0	0	1	0	0	0	8731	1623	56	5	1038	5	LCP1	13	46725072	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	26325968	46725072	68444806	67	9654											
MYO16	23026	broad.mit.edu	37	chr13	109777522	109777522	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	taagcatcagacaacaagagGtgacttctatcaatagcttt	15	11	7	8	0	3	3	2	1	1	2	3	3	3	3	0	1	3	2	0	1	6	5			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr13:109777522G>A	uc001vqt.1	+	30	3658	c.3532G>A	c.(3532-3534)GTG>ATG	p.V1178M	MYO16_uc010agk.1_Missense_Mutation_p.V1200M|MYO16_uc010tjh.1_Missense_Mutation_p.V690M	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1178					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ACAACAAGAGGTGACTTCTAT	0.438													17	25					0	0	0	0	A	109777522	A	A	109777522	3	1	47	1	0	0	0	0	1	0	0	0	10117	1261	44	4	3646	4	MYO16	13	109777522	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	63052450	109777522	5392356	68	9655											
C14orf4	64207	broad.mit.edu	37	chr14	77492316	77492316	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caggtggggtggtccggttgGaatggggtcccagaggtggg	5	8	22	6	1	0	1	0	0	0	1	2	2	2	2	2	10	0	1	2	10	1	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr14:77492316G>A	uc001xsy.2	-	1	2719	c.1820C>T	c.(1819-1821)TCC>TTC	p.S607F		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	607	Pro-rich.					nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		GGTCCGGTTGGAATGGGGTCC	0.517													3	12					0	0	0	0	A	77492316	A	A	77492316	3	1	47	1	0	0	0	0	1	0	0	0	1779	1174	41	2	574	2	C14orf4	14	77492316	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08		77492316	29857224	69	9656											
ASB2	51676	broad.mit.edu	37	chr14	94413768	94413768	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtcttgttggcgtcggcacCctgtgacagcagaaactcca	8	9	12	12	2	1	2	0	1	1	1	3	2	2	2	2	3	2	3	2	3	1	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr14:94413768C>T	uc001ycc.1	-	5	1324	c.835G>A	c.(835-837)GGT>AGT	p.G279S	ASB2_uc001ycd.2_Missense_Mutation_p.G327S|ASB2_uc001yce.1_Missense_Mutation_p.G225S	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	279	ANK 7.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		GCGTCGGCACCCTGTGACAGC	0.612													19	72					0	0	0	0	T	94413768	T	T	94413768	3	4	47	1	0	0	0	0	1	0	0	0	1025	623	22	4	944	4	ASB2	14	94413768	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	16921452	94413768	12935772	70	9657											
RTL1	388015	broad.mit.edu	37	chr14	101349254	101349254	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctgtagcctggctctttcTtgcatcctggcacccacagg	5	12	9	15	0	2	0	0	0	2	0	4	0	4	0	4	3	2	4	4	3	1	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr14:101349254T>A	uc010txj.1	-	1	1931	c.1872A>T	c.(1870-1872)CAA>CAT	p.Q624H	uc001yig.3_5'Flank|MIR127_hsa-mir-127|MI0000472_5'Flank|MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	624										pancreas(1)	1						TGGCTCTTTCTTGCATCCTGG	0.547													4	19					0	0	0	0	A	101349254	A	A	101349254	3	1	47	1	0	0	0	0	1	0	0	0	13789	1606	56	5	2208	5	RTL1	14	101349254	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	6935486	101349254	6000286	71	9658											
ZNF770	54989	broad.mit.edu	37	chr15	35274909	35274909	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	taataaaagagcccgaaaagCcttattcctagtatggattt	15	12	7	7	1	0	1	0	0	0	1	1	3	1	2	3	1	2	1	3	1	8	7			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr15:35274909C>T	uc001ziw.2	-	3	1038	c.727G>A	c.(727-729)GCT>ACT	p.A243T		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		GCCCGAAAAGCCTTATTCCTA	0.363													20	51					0	0	0	0	T	35274909	T	T	35274909	3	4	47	1	0	0	0	0	1	0	0	0	18210	739	26	4	1352	4	ZNF770	15	35274909	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08		35274909	67256483	72	9659											
CREBBP	1387	broad.mit.edu	37	chr16	3817904	3817904	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agctccttgcaaatcctcctCcatcatcttgagaaaaacat	13	11	4	13	0	2	1	1	1	1	1	6	2	6	1	4	0	3	2	4	0	3	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:3817904C>T	uc002cvv.2	-	16	3271	c.3067G>A	c.(3067-3069)GAG>AAG	p.E1023K	CREBBP_uc002cvw.2_Missense_Mutation_p.E985K	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1023					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AAATCCTCCTCCATCATCTTG	0.388			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				22	132					0	0	0	0	T	3817904	T	T	3817904	3	4	47	1	0	0	0	0	1	0	0	0	3876	864	30	2	4325	2	CREBBP	16	3817904	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08		3817904	86536849	73	9660											
ACSM5	54988	broad.mit.edu	37	chr16	20432686	20432686	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagatggtcgagcactccCagagcagctacggactgggt	10	6	13	12	2	0	2	0	0	0	2	2	4	1	3	2	3	4	3	2	3	2	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:20432686C>A	uc002dhe.2	+	5	877	c.730C>A	c.(730-732)CAG>AAG	p.Q244K		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	244					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						CGAGCACTCCCAGAGCAGCTA	0.423													8	41					5.18039e-06	5.87419e-06	1	0	A	20432686	A	A	20432686	3	1	47	1	0	0	0	0	1	0	0	0	187	595	21	4	744	4	ACSM5	16	20432686	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	16614782	20432686	69922067	74	9661											
SLC5A11	115584	broad.mit.edu	37	chr16	24921693	24921693	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggaacaagcaccaccagcaGctcccttgtctcttaccctc	10	8	6	17	0	1	0	0	0	1	0	4	1	2	1	4	1	5	3	4	1	3	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:24921693G>A	uc002dmu.2	+	15	1949	c.1717G>A	c.(1717-1719)GCT>ACT	p.A573T	SLC5A11_uc002dms.2_Missense_Mutation_p.A509T|SLC5A11_uc010vcd.1_Missense_Mutation_p.A538T|SLC5A11_uc002dmt.2_Missense_Mutation_p.A417T|SLC5A11_uc010vce.1_Missense_Mutation_p.A503T|SLC5A11_uc010bxt.2_Missense_Mutation_p.A509T|SLC5A11_uc002dmv.2_Missense_Mutation_p.A196T	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	573	Cytoplasmic (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		ACCACCAGCAGCTCCCTTGTC	0.542													25	119					0	0	0	0	A	24921693	A	A	24921693	3	1	47	1	0	0	0	0	1	0	0	0	14727	971	34	4	1771	4	SLC5A11	16	24921693	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	4489007	24921693	65433060	75	9662											
PLA2G15	23659	broad.mit.edu	37	chr16	68289188	68289188	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtatttctgtctacaggttCctatttccacaccatggtgg	7	16	8	10	0	2	0	0	0	2	0	4	0	4	0	3	3	1	2	3	3	3	6			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:68289188C>T	uc002evr.2	+	4	490	c.407C>T	c.(406-408)TCC>TTC	p.S136F	PLA2G15_uc010vld.1_Missense_Mutation_p.S136F|PLA2G15_uc010vle.1_Missense_Mutation_p.P84S|PLA2G15_uc010vlf.1_Intron|PLA2G15_uc002evs.2_5'UTR	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	lysophospholipase 3 (lysosomal phospholipase A2)	136					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			ovary(1)	1						TCTACAGGTTCCTATTTCCAC	0.557													8	28					0	0	0	0	T	68289188	T	T	68289188	3	4	47	1	0	0	0	0	1	0	0	0	12047	855	30	2	421	2	PLA2G15	16	68289188	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	43367495	68289188	22065565	76	9663											
DHODH	1723	broad.mit.edu	37	chr16	72057436	72057436	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggacgcgctggagaagatccGggcaggggcctccctggtgc	6	5	18	12	3	0	2	0	0	0	2	2	4	2	3	3	6	1	2	3	6	1	0			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:72057436G>A	uc002fbp.2	+	8	1058	c.1037G>A	c.(1036-1038)CGG>CAG	p.R346Q	DHODH_uc010cgk.2_RNA	NM_001361	NP_001352	Q02127	PYRD_HUMAN	dihydroorotate dehydrogenase precursor	346	Mitochondrial intermembrane (By similarity).		R -> W (in POADS).		'de novo' pyrimidine base biosynthetic process|pyrimidine nucleoside biosynthetic process|UMP biosynthetic process	integral to membrane|mitochondrial inner membrane	dihydroorotate oxidase activity				0		Ovarian(137;0.125)			Atovaquone(DB01117)|Leflunomide(DB01097)	GAGAAGATCCGGGCAGGGGCC	0.607													29	113					0	0	0	0	A	72057436	A	A	72057436	3	1	47	1	0	0	0	0	1	0	0	0	4506	1116	39	1	1067	1	DHODH	16	72057436	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	3768248	72057436	18297317	77	9664											
WFDC1	58189	broad.mit.edu	37	chr16	84328674	84328674	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacgccggctctgccaagAatatctggaaacgggcattg	10	8	11	12	3	2	1	0	0	2	1	3	2	3	2	3	3	2	2	3	3	4	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr16:84328674A>T	uc002fhw.2	+	1	274	c.97A>T	c.(97-99)AAT>TAT	p.N33Y	WFDC1_uc002fhv.2_Missense_Mutation_p.N33Y	NM_021197	NP_067020	Q9HC57	WFDC1_HUMAN	WAP four-disulfide core domain 1 precursor	33				N -> D (in Ref. 3; BAC11377).	negative regulation of cell growth	extracellular space	serine-type endopeptidase inhibitor activity			breast(1)	1						CTCTGCCAAGAATATCTGGAA	0.632													25	120					0	0	0	0	T	84328674	T	T	84328674	3	4	47	1	0	0	0	0	1	0	0	0	17414	246	9	5	99	5	WFDC1	16	84328674	Missense_Mutation	SNP	A	TCGA-CN-4736-01A-01D-1434-08	12271238	84328674	6026079	78	9665											
TP53	7157	broad.mit.edu	37	chr17	7578271	7578271	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccttccactcggataagaTgctgaggaggggccagacct	9	9	12	11	1	0	3	0	1	0	2	3	5	2	5	4	4	1	1	4	4	1	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:7578271T>G	uc002gim.2	-	6	772	c.578A>C	c.(577-579)CAT>CCT	p.H193P	TP53_uc002gig.1_Missense_Mutation_p.H193P|TP53_uc002gih.2_Missense_Mutation_p.H193P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H61P|TP53_uc010cng.1_Missense_Mutation_p.H61P|TP53_uc002gii.1_Missense_Mutation_p.H61P|TP53_uc010cnh.1_Missense_Mutation_p.H193P|TP53_uc010cni.1_Missense_Mutation_p.H193P|TP53_uc002gij.2_Missense_Mutation_p.H193P|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100P|TP53_uc002gio.2_Missense_Mutation_p.H61P|TP53_uc010vug.1_Missense_Mutation_p.H154P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	193	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> D (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(67)|p.H193L(31)|p.H193Y(26)|p.H193P(12)|p.0?(7)|p.H193D(7)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.H193H(2)|p.P191fs*53(2)|p.K164_P219del(1)|p.P191fs*15(1)|p.P191fs*6(1)|p.H100L(1)|p.H61L(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	50					0	0	0	0	G	7578271	G	G	7578271	3	3	47	1	0	0	0	0	1	0	0	0	16448	1464	51	5	716	5	TP53	17	7578271	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08		7578271	73616939	79	9666											
TP53	7157	broad.mit.edu	37	chr17	7578395	7578395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctatctgagcagcgctcatGgtgggggcagcgcctcacaa	8	7	14	12	2	3	1	2	1	1	0	3	1	3	1	1	3	3	4	1	3	2	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:7578395G>A	uc002gim.2	-	5	729	c.535C>T	c.(535-537)CAT>TAT	p.H179Y	TP53_uc002gig.1_Missense_Mutation_p.H179Y|TP53_uc002gih.2_Missense_Mutation_p.H179Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47Y|TP53_uc010cng.1_Missense_Mutation_p.H47Y|TP53_uc002gii.1_Missense_Mutation_p.H47Y|TP53_uc010cnh.1_Missense_Mutation_p.H179Y|TP53_uc010cni.1_Missense_Mutation_p.H179Y|TP53_uc002gij.2_Missense_Mutation_p.H179Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86Y|TP53_uc002gio.2_Missense_Mutation_p.H47Y|TP53_uc010vug.1_Missense_Mutation_p.H140Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCTCATGGTGGGGGCAG	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	58					0	0	0	0	A	7578395	A	A	7578395	3	1	47	1	0	0	0	0	1	0	0	0	16448	1348	47	4	763	4	TP53	17	7578395	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	124	7578395	73616815	80	9667											
CCDC42	146849	broad.mit.edu	37	chr17	8638565	8638565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgttctggatgtgcgcccagCgagattcctggagagtggat	7	11	15	8	2	1	2	0	0	1	2	2	6	2	4	2	3	2	1	2	3	0	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:8638565C>T	uc002gln.2	-	6	949	c.722G>A	c.(721-723)CGC>CAC	p.R241H	CCDC42_uc002glo.2_Missense_Mutation_p.R167H	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	241										ovary(1)	1						GTGCGCCCAGCGAGATTCCTG	0.473													5	56					0	0	0	0	T	8638565	T	T	8638565	3	4	47	1	0	0	0	0	1	0	0	0	2827	768	27	1	236	1	CCDC42	17	8638565	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	1060170	8638565	72556645	81	9668											
MYH4	4622	broad.mit.edu	37	chr17	10351237	10351237	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcattaagatctccctccatCttcttcttgatcctcagagc	8	15	4	14	0	6	3	2	1	4	2	9	3	8	3	3	0	1	0	3	0	1	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:10351237C>T	uc002gmn.2	-	34	4974	c.4863G>A	c.(4861-4863)AAG>AAA	p.K1621K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1621	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CTCCCTCCATCTTCTTCTTGA	0.458													9	278					0	0	0	0	T	10351237	T	T	10351237	2	4	47	1	0	0	0	0	0	0	0	1	10090	912	32	2		2	MYH4	17	10351237	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08	1712672	10351237	70843973	82	9669											
MYOCD	93649	broad.mit.edu	37	chr17	12639605	12639605	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcgggatccccgccagaCgctaaagcctcagatacccc	10	5	9	17	3	2	2	2	0	0	2	3	3	3	3	6	1	3	1	6	1	3	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:12639605C>T	uc002gnn.2	+	6	842	c.543C>T	c.(541-543)GAC>GAT	p.D181D	MYOCD_uc002gno.2_Silent_p.D181D|MYOCD_uc002gnp.1_Silent_p.D85D	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	181	HDAC5-binding (By similarity).				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CCCCGCCAGACGCTAAAGCCT	0.488													26	119					0	0	0	0	T	12639605	T	T	12639605	2	4	47	1	0	0	0	0	0	0	0	1	10140	535	19	1		1	MYOCD	17	12639605	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08	2288368	12639605	68555605	83	9670											
IMP5	162540	broad.mit.edu	37	chr17	43923368	43923368	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcctgttcgtcctgcacCgtgtgcggctgcccactctc	3	11	10	17	3	1	0	0	0	1	0	4	0	2	0	4	1	4	3	4	1	0	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:43923368C>T	uc010wka.1	+	1	1096	c.1096C>T	c.(1096-1098)CGT>TGT	p.R366C	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	366	Extracellular (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		CGTCCTGCACCGTGTGCGGCT	0.582													13	34					0	0	0	0	T	43923368	T	T	43923368	3	4	47	1	0	0	0	0	1	0	0	0	7760	652	23	1	1098	1	IMP5	17	43923368	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	31283763	43923368	37271842	84	9671											
CACNA1G	8913	broad.mit.edu	37	chr17	48699100	48699100	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctctctagctctgacggAtgactctttgcctgatgaca	7	13	9	12	1	3	4	0	4	3	0	4	5	3	5	1	1	3	2	1	1	1	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr17:48699100A>T	uc002irk.1	+	35	6377	c.6005A>T	c.(6004-6006)GAT>GTT	p.D2002V	CACNA1G_uc002irj.1_Intron|CACNA1G_uc002irl.1_Intron|CACNA1G_uc002irm.1_Intron|CACNA1G_uc002irn.1_Intron|CACNA1G_uc002iro.1_Intron|CACNA1G_uc002irp.1_Intron|CACNA1G_uc002irq.1_Missense_Mutation_p.D1979V|CACNA1G_uc002irr.1_Intron|CACNA1G_uc002irs.1_Intron|CACNA1G_uc002irt.1_Intron|CACNA1G_uc002irv.1_Intron|CACNA1G_uc002irw.1_Missense_Mutation_p.D1931V|CACNA1G_uc002iru.1_Missense_Mutation_p.D1968V|CACNA1G_uc002irx.1_Intron|CACNA1G_uc002iry.1_Intron|CACNA1G_uc002irz.1_Intron|CACNA1G_uc002isa.1_Intron|CACNA1G_uc002isb.1_Intron|CACNA1G_uc002isc.1_Missense_Mutation_p.D1904V|CACNA1G_uc002isd.1_Intron|CACNA1G_uc002ise.1_Intron|CACNA1G_uc002isf.1_Intron|CACNA1G_uc002isg.1_Intron|CACNA1G_uc002ish.1_Intron|CACNA1G_uc002isi.1_Intron	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	2002	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCTCTGACGGATGACTCTTTG	0.547													5	67					0	0	0	0	T	48699100	T	T	48699100	3	4	47	1	0	0	0	0	1	0	0	0	2556	333	12	5	6410	5	CACNA1G	17	48699100	Missense_Mutation	SNP	A	TCGA-CN-4736-01A-01D-1434-08	4775732	48699100	32496110	85	9672											
DLGAP1	9229	broad.mit.edu	37	chr18	3880018	3880018	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagcgagtcacaggccgaGtcgcaggtgaccccgtggtg	8	5	16	12	4	1	1	1	1	0	0	2	4	1	1	3	3	1	1	3	3	0	0			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr18:3880018G>A	uc002kmf.2	-	1	118	c.51C>T	c.(49-51)GAC>GAT	p.D17D	DLGAP1_uc010wyz.1_Silent_p.D17D|DLGAP1_uc002kmk.2_Silent_p.D17D|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	17					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CACAGGCCGAGTCGCAGGTGA	0.662													14	27					0	0	0	0	A	3880018	A	A	3880018	2	1	47	1	0	0	0	0	0	0	0	1	4581	1020	36	4		4	DLGAP1	18	3880018	Silent	SNP	G	TCGA-CN-4736-01A-01D-1434-08		3880018	74197230	86	9673											
CHST9	83539	broad.mit.edu	37	chr18	24496367	24496367	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcggaagagtgcctatcCttaaagttgggaaatttcag	12	12	10	7	1	2	1	2	0	0	1	4	3	3	3	2	2	1	1	2	2	5	4			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr18:24496367C>G	uc002kwd.2	-	5	1386	c.1188G>C	c.(1186-1188)AAG>AAC	p.K396N	C18orf16_uc002kwb.2_Intron|C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_Missense_Mutation_p.K311N|CHST9_uc002kwe.2_Missense_Mutation_p.K396N	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	396	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					AGTGCCTATCCTTAAAGTTGG	0.368													47	165					0	0	0	0	G	24496367	G	G	24496367	3	3	47	1	0	0	0	0	1	0	0	0	3426	680	24	4	147	4	CHST9	18	24496367	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	20616349	24496367	53580881	87	9674											
CPLX4	339302	broad.mit.edu	37	chr18	56963955	56963955	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcacggaacacttctgctccGctgtctgcttgatttcagtg	6	14	9	12	2	4	1	2	1	2	0	5	2	5	2	1	1	3	3	1	1	1	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr18:56963955G>A	uc002lhy.2	-	3	645	c.458C>T	c.(457-459)GCG>GTG	p.A153V		NM_181654	NP_857637	Q7Z7G2	CPLX4_HUMAN	complexin 4 precursor	153					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			ovary(1)	1		Colorectal(73;0.175)				CTTCTGCTCCGCTGTCTGCTT	0.498													13	60					0	0	0	0	A	56963955	A	A	56963955	3	1	47	1	0	0	0	0	1	0	0	0	3822	1087	38	1	28	1	CPLX4	18	56963955	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	32467588	56963955	21113293	88	9675											
INSR	3643	broad.mit.edu	37	chr19	7122639	7122639	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acgaacctccaattttgacaGtaaaatcatgggcgaccatg	14	9	8	10	2	1	1	1	1	0	0	2	3	2	1	3	1	1	1	3	1	4	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:7122639G>A	uc002mgd.1	-	19	3624	c.3515C>T	c.(3514-3516)ACT>ATT	p.T1172I	INSR_uc002mge.1_Missense_Mutation_p.T1160I	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1172	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AATTTTGACAGTAAAATCATG	0.488													3	94					0	0	0	0	A	7122639	A	A	7122639	3	1	47	1	0	0	0	0	1	0	0	0	7812	1029	36	4	649	4	INSR	19	7122639	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08		7122639	52006344	89	9676											
MUC16	94025	broad.mit.edu	37	chr19	9056421	9056421	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagggctgggatggttgaaGaatcagtggtagtgaaggtt	10	10	19	2	0	1	3	1	2	0	1	1	5	1	5	0	6	0	4	0	6	4	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:9056421G>A	uc002mkp.2	-	3	31229	c.31025C>T	c.(31024-31026)TCT>TTT	p.S10342F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10344	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATGGTTGAAGAATCAGTGGT	0.532													20	54					0	0	0	0	A	9056421	A	A	9056421	3	1	47	1	0	0	0	0	1	0	0	0	10026	942	33	2	12826	2	MUC16	19	9056421	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	1933782	9056421	50072562	90	9677											
CYP4F11	57834	broad.mit.edu	37	chr19	16038133	16038133	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccacttgtcaccaccactCagcaggagcccatcccctgg	8	7	7	19	0	2	0	2	0	0	0	4	1	4	1	6	2	2	1	6	2	0	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:16038133C>A	uc002nbu.2	-	5	450	c.414G>T	c.(412-414)CTG>CTT	p.L138L	CYP4F11_uc010eab.1_Silent_p.L138L|CYP4F11_uc002nbt.2_Silent_p.L138L	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	138					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						CACCACCACTCAGCAGGAGCC	0.527													21	102					0.00229938	0.00245396	1	0	A	16038133	A	A	16038133	2	1	47	1	0	0	0	0	0	0	0	1	4203	813	29	2		2	CYP4F11	19	16038133	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08	6981712	16038133	43090850	91	9678											
TSHZ3	57616	broad.mit.edu	37	chr19	31768676	31768676	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatccttgcacccatcccGcggggggctggggctgttct	3	9	13	16	2	1	0	0	0	1	0	3	0	3	0	4	5	1	4	4	5	0	2	rs143305127		TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:31768676G>A	uc002nsy.3	-	2	2088	c.2023C>T	c.(2023-2025)CGG>TGG	p.R675W		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	675					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CACCCATCCCGCGGGGGGCTG	0.652													15	56					0	0	0	0	A	31768676	A	A	31768676	3	1	47	1	0	0	0	0	1	0	0	0	16692	1086	38	1	1226	1	TSHZ3	19	31768676	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	15730543	31768676	27360307	92	9679											
TFPT	29844	broad.mit.edu	37	chr19	54613495	54613495	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atggagcctgttcaggacccGctcgttcacctatggggtgg	6	10	14	11	2	2	0	2	0	0	0	3	2	2	2	3	5	1	3	3	5	1	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:54613495G>A	uc010yej.1	-	3	698	c.292C>T	c.(292-294)CGG>TGG	p.R98W	TFPT_uc010erd.2_Missense_Mutation_p.R98W	NM_013342	NP_037474	P0C1Z6	TFPT_HUMAN	TCF3 (E2A) fusion partner	98					apoptosis|DNA recombination|DNA repair|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex	DNA binding|protein binding				0	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)					TTCAGGACCCGCTCGTTCACC	0.577			T	TCF3	pre-B ALL								11	39					0	0	0	0	A	54613495	A	A	54613495	3	1	47	1	0	0	0	0	1	0	0	0	15876	1086	38	1	485	1	TFPT	19	54613495	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	22844819	54613495	4515488	93	9680											
SYT5	6861	broad.mit.edu	37	chr19	55689729	55689729	+	Frame_Shift_Del	DEL	G	-	-																															acgatggtggccagggcccaGgggggcactgcagaggggtg																										TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr19:55689729delG	uc002qjm.1	-	2	1147	c.87delC	c.(85-87)CCCfs	p.P29fs	SYT5_uc002qjp.2_Intron|SYT5_uc002qjn.1_Frame_Shift_Del_p.P29fs|SYT5_uc002qjo.1_Frame_Shift_Del_p.P29fs	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	29	Helical; (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CCAGGGCCCAGGGGGGCACTG	0.602													---	---	---								-	55689729	-	-	55689729	7	5	47	1	0	1	0	1	0	0	0	0	15543	987	35	0	1101	0	SYT5	19	55689729	Frame_Shift_Del	DEL	G	TCGA-CN-4736-01A-01D-1434-08	1076234	55689729	3439254	94	9681											
C20orf79	140856	broad.mit.edu	37	chr20	18794840	18794840	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcaaaatgaacccgcagaaGgctttccttgccggaaagtt	12	8	11	10	2	0	2	0	1	0	1	1	3	1	3	3	3	2	4	3	3	5	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr20:18794840G>A	uc002wrk.2	+	1	471	c.381G>A	c.(379-381)AAG>AAA	p.K127K	uc002wrj.1_Intron	NM_178483	NP_848578	Q9UJQ7	CT079_HUMAN	hypothetical protein LOC140856	127	SCP2.						sterol binding			skin(3)	3						ACCCGCAGAAGGCTTTCCTTG	0.483													24	82					0	0	0	0	A	18794840	A	A	18794840	2	1	47	1	0	0	0	0	0	0	0	1	2129	991	35	4		4	C20orf79	20	18794840	Silent	SNP	G	TCGA-CN-4736-01A-01D-1434-08		18794840	44230680	95	9682											
MYO18B	84700	broad.mit.edu	37	chr22	26168444	26168444	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgatctgattgtcctccaGccccgggggccctcggtgcc	3	9	12	17	2	1	2	0	2	1	0	4	2	3	2	7	3	2	0	7	3	0	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr22:26168444G>T	uc003abz.1	+	7	2086	c.1836G>T	c.(1834-1836)CAG>CAT	p.Q612H	MYO18B_uc003aca.1_Missense_Mutation_p.Q493H|MYO18B_uc010guy.1_Missense_Mutation_p.Q493H|MYO18B_uc010guz.1_Missense_Mutation_p.Q493H|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_Missense_Mutation_p.Q125H	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	612	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TTGTCCTCCAGCCCCGGGGGC	0.637													7	37					2.0095e-06	2.29915e-06	1	0	T	26168444	T	T	26168444	3	4	47	1	0	0	0	0	1	0	0	0	10119	962	34	4	1858	4	MYO18B	22	26168444	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08		26168444	25136122	96	9683											
PES1	23481	broad.mit.edu	37	chr22	30976074	30976074	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtctgctgcccaggccggtCgacaatctgatgggtgatgc	6	9	15	11	2	2	2	0	2	2	0	3	3	2	2	2	4	3	1	2	4	1	0			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr22:30976074C>T	uc003aij.1	-	11	1209	c.1135G>A	c.(1135-1137)GAC>AAC	p.D379N	PES1_uc003aik.1_Missense_Mutation_p.D374N|PES1_uc003ail.1_Missense_Mutation_p.D362N|PES1_uc003aim.1_Missense_Mutation_p.D379N|PES1_uc003ain.1_Missense_Mutation_p.D240N|PES1_uc003aio.1_Missense_Mutation_p.D240N	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	379	Sufficient for interaction with MAP1B (By similarity).|BRCT.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						CCAGGCCGGTCGACAATCTGA	0.572													31	129					0	0	0	0	T	30976074	T	T	30976074	3	4	47	1	0	0	0	0	1	0	0	0	11787	884	31	1	651	1	PES1	22	30976074	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	4807630	30976074	20328492	97	9684											
TXN2	25828	broad.mit.edu	37	chr22	36876729	36876729	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaggagatcctcgtggtgtaTattgtccgggctgggttggg	6	12	17	6	2	0	1	0	0	0	1	3	2	2	1	2	5	0	3	2	5	3	4	rs146269725	by1000genomes	TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chr22:36876729T>C	uc003apk.1	-	2	233	c.156A>G	c.(154-156)ATA>ATG	p.I52M	TXN2_uc003apl.1_RNA	NM_012473	NP_036605	Q99757	THIOM_HUMAN	thioredoxin 2 precursor	52					cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	mitochondrion|nucleolus	electron carrier activity				0						TCGTGGTGTATATTGTCCGGG	0.547													24	89					0	0	0	0	C	36876729	C	C	36876729	3	2	47	1	0	0	0	0	1	0	0	0	16859	1396	49	5	356	5	TXN2	22	36876729	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	5900655	36876729	14427837	98	9685											
ARMCX2	9823	broad.mit.edu	37	chrX	100911937	100911937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcagctgcctcggtaggcGatgccaccccgggagcttca	6	7	12	16	3	2	0	2	0	0	0	3	2	2	1	5	3	4	3	5	3	1	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:100911937G>A	uc004eid.2	-	3	993	c.638C>T	c.(637-639)TCG>TTG	p.S213L	ARMCX2_uc004eie.3_Missense_Mutation_p.S213L|ARMCX2_uc004eif.3_Missense_Mutation_p.S213L|ARMCX2_uc004eig.3_Missense_Mutation_p.S213L|ARMCX2_uc010nnt.2_Missense_Mutation_p.S213L	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	213	Ala-rich.					integral to membrane	binding			ovary(6)	6						CTCGGTAGGCGATGCCACCCC	0.647													8	54					0	0	0	0	A	100911937	A	A	100911937	3	1	47	1	0	0	0	0	1	0	0	0	962	1059	37	1	1264	1	ARMCX2	23	100911937	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08		100911937	54358623	99	9686											
XPNPEP2	7512	broad.mit.edu	37	chrX	128895151	128895151	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctctcttcccttccagggcGaatggtggaggcctttgccc	4	12	11	14	1	2	0	0	0	2	0	5	2	4	1	4	4	1	0	4	4	1	3			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:128895151G>A	uc004eut.1	+	17	1746	c.1502G>A	c.(1501-1503)CGA>CAA	p.R501Q		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	501					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						CTTCCAGGGCGAATGGTGGAG	0.547													6	48					0	0	0	0	A	128895151	A	A	128895151	3	1	47	1	0	0	0	0	1	0	0	0	17511	1058	37	1	1568	1	XPNPEP2	23	128895151	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	27983214	128895151	26375409	100	9687											
ATP11C	286410	broad.mit.edu	37	chrX	138864754	138864754	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcatgtttgtctcaataTcatcgaaaactttttccatt	12	18	3	8	1	3	0	3	0	1	0	6	1	4	0	1	0	1	1	1	0	5	6			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:138864754T>A	uc004faz.2	-	18	2012	c.1913A>T	c.(1912-1914)GAT>GTT	p.D638V	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.D638V	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	638	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TGTCTCAATATCATCGAAAAC	0.338													15	84					0	0	0	0	A	138864754	A	A	138864754	3	1	47	1	0	0	0	0	1	0	0	0	1123	1435	50	5	1600	5	ATP11C	23	138864754	Missense_Mutation	SNP	T	TCGA-CN-4736-01A-01D-1434-08	9969603	138864754	16405806	101	9688											
MAMLD1	10046	broad.mit.edu	37	chrX	149639239	149639239	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcccagagaagctctctaGcccaggcttgccacagcagt	9	7	10	15	1	1	1	0	0	1	1	3	2	1	1	3	1	4	3	3	1	2	2			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:149639239G>T	uc004fee.1	+	3	1470	c.1394G>T	c.(1393-1395)AGC>ATC	p.S465I	MAMLD1_uc011mxt.1_Missense_Mutation_p.S427I|MAMLD1_uc011mxu.1_Missense_Mutation_p.S440I|MAMLD1_uc011mxv.1_Missense_Mutation_p.S440I|MAMLD1_uc011mxw.1_Missense_Mutation_p.S392I	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	465					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCTCTCTAGCCCAGGCTTG	0.517													18	183					2.48551e-13	3.03518e-13	1	0	T	149639239	T	T	149639239	3	4	47	1	0	0	0	0	1	0	0	0	9261	971	34	4	1404	4	MAMLD1	23	149639239	Missense_Mutation	SNP	G	TCGA-CN-4736-01A-01D-1434-08	10774485	149639239	5631321	102	9689											
GAB3	139716	broad.mit.edu	37	chrX	153924265	153924265	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcagaattaataccatttCtttctggagagagaaagctg	13	13	9	6	0	2	3	0	0	2	3	2	5	2	3	1	1	3	2	1	1	4	5			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:153924265C>A	uc004fmj.1	-	8	1502	c.1454G>T	c.(1453-1455)AGA>ATA	p.R485I	GAB3_uc004fmk.1_Missense_Mutation_p.R486I|GAB3_uc010nve.1_Missense_Mutation_p.R486I|GAB3_uc004fml.1_Missense_Mutation_p.R105I	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	485										ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AATACCATTTCTTTCTGGAGA	0.373													14	78					3.35478e-16	4.13647e-16	1	0	A	153924265	A	A	153924265	3	1	47	1	0	0	0	0	1	0	0	0	6184	913	32	2	318	2	GAB3	23	153924265	Missense_Mutation	SNP	C	TCGA-CN-4736-01A-01D-1434-08	4285026	153924265	1346295	103	9690											
IL9R	3581	broad.mit.edu	37	chrX	155227436	155227436	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacttgtgatgggactgggCagatgcatctgggaaggtga	10	9	17	5	0	1	4	0	2	1	2	1	6	1	6	0	4	1	2	0	4	1	1			TCGA-CN-4736-01A-01D-1434-08	TCGA-CN-4736-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	788337f5-722c-45d6-8ca4-8037c489cb64	1723fc6d-c346-4dba-a04c-4dad42afee1e	g.chrX:155227436C>A	uc004fnv.1	+	1	191	c.12C>A	c.(10-12)GGC>GGA	p.G4G	IL9R_uc010nvn.2_5'UTR|IL9R_uc004fnu.1_Missense_Mutation_p.Q10K	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	4					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGGGACTGGGCAGATGCATCT	0.542													10	81					1.58986e-06	1.85241e-06	1	0	A	155227436	A	A	155227436	2	1	47	1	0	0	0	0	0	0	0	1	7747	697	25	4		4	IL9R	23	155227436	Silent	SNP	C	TCGA-CN-4736-01A-01D-1434-08	1303171	155227436	43124	104	9691											
ACTRT2	140625	broad.mit.edu	37	chr1	2938804	2938804	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcaccaagctccacgtggCgggcagggacatcacggagc	10	4	14	13	3	2	0	2	0	0	0	3	2	3	2	2	4	2	2	2	4	1	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:2938804C>T	uc001ajz.2	+	1	759	c.554C>T	c.(553-555)GCG>GTG	p.A185V		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	185						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		CTCCACGTGGCGGGCAGGGAC	0.642													12	79					0	0	0	0	T	2938804	T	T	2938804	3	4	48	1	0	0	0	0	1	0	0	0	219	768	27	1	556	1	ACTRT2	1	2938804	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08		2938804	246311817	1	9692											
KIF1B	23095	broad.mit.edu	37	chr1	10394634	10394634	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcccctgatccacagggtggCcatcgtcagtgagaaaggtg	9	7	14	11	1	1	2	1	2	0	1	3	3	2	2	4	3	0	0	4	3	1	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:10394634C>T	uc001aqx.3	+	28	3183	c.2981C>T	c.(2980-2982)GCC>GTC	p.A994V	KIF1B_uc001aqw.3_Missense_Mutation_p.A948V|KIF1B_uc001aqy.2_Missense_Mutation_p.A968V|KIF1B_uc001aqz.2_Missense_Mutation_p.A994V|KIF1B_uc001ara.2_Missense_Mutation_p.A954V|KIF1B_uc001arb.2_Missense_Mutation_p.A980V	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	994					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CACAGGGTGGCCATCGTCAGT	0.517													75	187					0	0	0	0	T	10394634	T	T	10394634	3	4	48	1	0	0	0	0	1	0	0	0	8323	739	26	4	4430	4	KIF1B	1	10394634	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	7455830	10394634	238855987	2	9693											
ZBTB17	7709	broad.mit.edu	37	chr1	16270105	16270105	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accacccacctgtgtgaatgCggacgtgccgctgcagagcg	8	6	13	14	4	0	2	0	1	0	1	0	3	0	3	4	1	4	2	4	1	1	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:16270105C>T	uc001axl.3	-	11	1804	c.1565G>A	c.(1564-1566)CGC>CAC	p.R522H	ZBTB17_uc010obq.1_Missense_Mutation_p.R439H|ZBTB17_uc010obr.1_Missense_Mutation_p.R522H|ZBTB17_uc010obs.1_Missense_Mutation_p.R446H	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	522	C2H2-type 8.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TGTGTGAATGCGGACGTGCCG	0.662													4	140					0	0	0	0	T	16270105	T	T	16270105	3	4	48	1	0	0	0	0	1	0	0	0	17594	768	27	1	870	1	ZBTB17	1	16270105	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	5875471	16270105	232980516	3	9694											
EPHB2	2048	broad.mit.edu	37	chr1	23191380	23191380	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgccccagccatcccctcCgcgccccaggctgtgatttc	4	7	8	22	3	0	1	0	1	0	0	3	1	2	1	9	1	1	1	9	1	0	1			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:23191380C>T	uc009vqj.1	+	5	1123	c.978C>T	c.(976-978)TCC>TCT	p.S326S	EPHB2_uc001bge.2_Silent_p.S326S|EPHB2_uc001bgf.2_Silent_p.S326S|EPHB2_uc010odu.1_Silent_p.S326S|hsa-mir-4253|MI0015860_5'Flank	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	326	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CCATCCCCTCCGCGCCCCAGG	0.652									Hereditary_Prostate_Cancer				16	116					0	0	0	0	T	23191380	T	T	23191380	2	4	48	1	0	0	0	0	0	0	0	1	5199	639	23	1		1	EPHB2	1	23191380	Silent	SNP	C	TCGA-CN-4737-01A-01D-1434-08	6921275	23191380	226059241	4	9695											
COL8A2	1296	broad.mit.edu	37	chr1	36563712	36563712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agggggtcccgggggcccggGaggccccggagggcccgtga	4	2	22	13	4	0	1	0	1	0	0	1	3	1	3	5	8	0	0	5	8	0	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:36563712G>A	uc001bzv.1	-	2	1577	c.1570C>T	c.(1570-1572)CCC>TCC	p.P524S	COL8A2_uc001bzw.1_Missense_Mutation_p.P459S	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	524	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGGGGCCCGGGAGGCCCCGGA	0.756													6	4					0	0	0	0	A	36563712	A	A	36563712	3	1	48	1	0	0	0	0	1	0	0	0	3721	1174	41	2	545	2	COL8A2	1	36563712	Missense_Mutation	SNP	G	TCGA-CN-4737-01A-01D-1434-08	13372332	36563712	212686909	5	9696											
KIAA0467	23334	broad.mit.edu	37	chr1	43900933	43900933	+	Frame_Shift_Del	DEL	T	-	-																															tctcttctggtggccgagagTgaagaagatctgtggcgcag																										TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:43900933delT	uc001cjk.1	+	27	3732	c.3270delT	c.(3268-3270)AGTfs	p.S1090fs		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1989						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGGCCGAGAGTGAAGAAGATC	0.572													---	---	---								-	43900933	-	-	43900933	7	5	48	1	0	1	0	1	0	0	0	0	8217	1693	59	0	3368	0	KIAA0467	1	43900933	Frame_Shift_Del	DEL	T	TCGA-CN-4737-01A-01D-1434-08	7337221	43900933	205349688	6	9697											
B4GALT2	8704	broad.mit.edu	37	chr1	44451059	44451059	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggggtggcgaggatgatGacatcttcaaccggtgagta	9	9	16	7	2	2	3	1	3	1	0	2	5	2	4	1	5	1	2	1	5	2	2			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:44451059G>T	uc001clg.2	+	5	1220	c.850G>T	c.(850-852)GAC>TAC	p.D284Y	B4GALT2_uc001clh.2_Missense_Mutation_p.D218Y|B4GALT2_uc010okl.1_Missense_Mutation_p.D313Y|B4GALT2_uc001cli.2_Missense_Mutation_p.D284Y	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	284	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	CGAGGATGATGACATCTTCAA	0.597													15	62					1.3612e-06	1.41493e-06	1	0	T	44451059	T	T	44451059	3	4	48	1	0	0	0	0	1	0	0	0	1273	1290	45	2	864	2	B4GALT2	1	44451059	Missense_Mutation	SNP	G	TCGA-CN-4737-01A-01D-1434-08	550126	44451059	204799562	7	9698											
TAL1	6886	broad.mit.edu	37	chr1	47685565	47685565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaggtcatctgggggcgCgccgccccctcccccacctc	4	5	12	20	3	2	0	1	0	1	0	4	1	3	1	6	4	0	0	6	4	0	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:47685565C>T	uc001cqx.2	-	4	1400	c.823G>A	c.(823-825)GCG>ACG	p.A275T	TAL1_uc009vyq.2_Silent_p.A31A|TAL1_uc001cqy.2_Missense_Mutation_p.A275T	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	275					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1						TCTGGGGGCGCGccgccccct	0.582			T	TRD@|SIL	lymphoblastic leukemia/biphasic								16	16					0	0	0	0	T	47685565	T	T	47685565	3	4	48	1	0	0	0	0	1	0	0	0	15607	768	27	1	176	1	TAL1	1	47685565	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	3234506	47685565	201565056	8	9699											
FGGY	55277	broad.mit.edu	37	chr1	60139745	60139745	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcgcaagaggtggagtcCgttcttgtgggtgctgctgt	4	13	16	8	2	1	1	0	0	1	1	3	2	2	2	1	3	2	4	1	3	1	2	rs114601020	by1000genomes	TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:60139745C>A	uc001czi.3	+	14	1664	c.1452C>A	c.(1450-1452)TCC>TCA	p.S484S	FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Silent_p.S508S|FGGY_uc001czj.3_Silent_p.S483S|FGGY_uc001czk.3_Silent_p.S372S|FGGY_uc001czl.3_Silent_p.S396S|FGGY_uc001czm.3_Silent_p.S185S	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	484					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					AGGTGGAGTCCGTTCTTGTGG	0.612													9	26					4.68919e-08	4.93928e-08	1	0	A	60139745	A	A	60139745	2	1	48	1	0	0	0	0	0	0	0	1	5903	639	23	3		3	FGGY	1	60139745	Silent	SNP	C	TCGA-CN-4737-01A-01D-1434-08	12454180	60139745	189110876	9	9700											
NBPF10	100132406	broad.mit.edu	37	chr1	145311785	145311785	+	Splice_Site	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactttttcctacttttccaCgctcagcagggagctgctgg	6	14	9	12	1	1	0	1	0	0	0	3	1	3	1	2	2	5	4	2	2	2	6	rs61816394	by1000genomes	TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:145311785C>G	uc001end.3	+	14	1889	c.1854_splice	c.e14-1	p.R618_splice	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_5'Flank|NBPF10_uc010oyl.1_5'Flank|NBPF10_uc010oyj.1_5'Flank	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TACTTTTCCACGCTCAGCAGG	0.453													3	121					0	0	0	0	G	145311785	G	G	145311785	5	3	48	1	0	0	0	0	0	0	1	0	10246	551	19	3		3	NBPF10	1	145311785	Splice_Site	SNP	C	TCGA-CN-4737-01A-01D-1434-08	85172040	145311785	103938836	10	9701											
IGSF8	93185	broad.mit.edu	37	chr1	160062156	160062156	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcggcatgctgcacccaggCgctgggggcacagtggtaca	7	6	16	12	2	0	0	0	0	0	0	1	0	0	0	1	5	3	6	1	5	1	1			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:160062156C>T	uc001fva.2	-	5	1687	c.1642G>A	c.(1642-1644)GCC>ACC	p.A548T	IGSF8_uc001fuz.2_Missense_Mutation_p.A548T|IGSF8_uc009wtf.2_Missense_Mutation_p.A548T	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	548	Ig-like C2-type 4.|Extracellular (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGCACCCAGGCGCTGGGGGCA	0.647													20	107					0	0	0	0	T	160062156	T	T	160062156	3	4	48	1	0	0	0	0	1	0	0	0	7643	768	27	1	207	1	IGSF8	1	160062156	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	14750371	160062156	89188465	11	9702											
GFPT1	2673	broad.mit.edu	37	chr2	69556851	69556851	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atccaagcatgatctctttgCgtctttcttgcatggagatc	8	15	8	10	1	3	2	0	1	3	1	6	3	4	2	1	1	3	2	1	1	1	3			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr2:69556851C>T	uc002sfh.2	-	15	1687	c.1508G>A	c.(1507-1509)CGC>CAC	p.R503H		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	521					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						GATCTCTTTGCGTCTTTCTTG	0.408													30	117					0	0	0	0	T	69556851	T	T	69556851	3	4	48	1	0	0	0	0	1	0	0	0	6382	768	27	1	557	1	GFPT1	2	69556851	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08		69556851	173642522	12	9703											
TXNDC9	10190	broad.mit.edu	37	chr2	99949494	99949494	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagaggttacttgtttctgCtgttgagctttccttagtgc	6	17	11	7	0	1	2	0	1	1	1	2	3	2	2	1	1	4	5	1	1	2	6			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr2:99949494C>T	uc002szz.2	-	2	371	c.180G>A	c.(178-180)CAG>CAA	p.Q60Q	TXNDC9_uc010yvp.1_Silent_p.Q77Q|TXNDC9_uc002taa.1_Silent_p.Q60Q	NM_005783	NP_005774	O14530	TXND9_HUMAN	thioredoxin domain containing 9	60					cell redox homeostasis		protein binding				0						CTTGTTTCTGCTGTTGAGCTT	0.388													42	143					0	0	0	0	T	99949494	T	T	99949494	2	4	48	1	0	0	0	0	0	0	0	1	16870	796	28	4		4	TXNDC9	2	99949494	Silent	SNP	C	TCGA-CN-4737-01A-01D-1434-08	30392643	99949494	143249879	13	9704											
MKI67IP	84365	broad.mit.edu	37	chr2	122485367	122485367	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgagtctcttgtatttctTcttttacacaggatatgggc	7	19	8	7	0	3	1	0	1	3	0	4	2	3	2	0	2	1	1	0	2	3	8			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr2:122485367T>A	uc002tnk.2	-	7	892	c.815A>T	c.(814-816)GAA>GTA	p.E272V	uc002tnj.1_Intron	NM_032390	NP_115766	Q9BYG3	MK67I_HUMAN	MKI67 interacting nucleolar phosphoprotein	272					protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TTGTATTTCTTCTTTTACACA	0.323													32	151					0	0	0	0	A	122485367	A	A	122485367	3	1	48	1	0	0	0	0	1	0	0	0	9652	1783	62	5	70	5	MKI67IP	2	122485367	Missense_Mutation	SNP	T	TCGA-CN-4737-01A-01D-1434-08	22535873	122485367	120714006	14	9705											
TTN	7273	broad.mit.edu	37	chr2	179399515	179399515	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttggtaaatgatattttCtggtctaatgtcaaagtgtc	10	17	10	4	0	3	1	1	1	2	0	4	1	3	1	0	3	0	2	0	3	5	6			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr2:179399515C>A	uc010zfg.1	-	307	94347	c.94123G>T	c.(94123-94125)GAA>TAA	p.E31375*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.E25070*|TTN_uc010zfi.1_Nonsense_Mutation_p.E25003*|TTN_uc010zfj.1_Nonsense_Mutation_p.E24878*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32302							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGATATTTTCTGGTCTAATG	0.368													48	63					2.13384e-23	2.40819e-23	1	0	A	179399515	A	A	179399515	4	1	48	1	0	0	0	0	0	1	0	0	16803	922	32	2	6172	2	TTN	2	179399515	Nonsense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	56914148	179399515	63799858	15	9706											
DNAJB3	414061	broad.mit.edu	37	chr2	234652585	234652585	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggatggccagaacggcccaCcaggcactggcacagcgagc	10	3	14	14	2	0	1	0	0	0	1	0	3	0	2	3	5	3	2	3	5	1	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr2:234652585C>T	uc002vuz.2	-	1	77	c.-22G>A	c.(-24--20)TGGTG>TGATG		UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron	NM_001001394	NP_001001394	Q8WWF6	DNJB3_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 3						protein folding		heat shock protein binding|unfolded protein binding				0						GAACGGCCCACCAGGCACTGG	0.677													8	25					0	0	0	0	T	234652585	T	T	234652585	1	4	48	1	0	0	0	0	0	0	0	0	4643	522	18	4		4	DNAJB3	2	234652585	Translation_Start_Site	SNP	C	TCGA-CN-4737-01A-01D-1434-08	55253070	234652585	8546788	16	9707											
FAM193A	8603	broad.mit.edu	37	chr4	2641515	2641515	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgggaactgcataataaacaCctgtttgaaaatctggtctt	13	13	8	7	0	2	1	0	1	2	0	2	2	2	2	1	2	3	2	1	2	6	4			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:2641515C>T	uc010icl.2	+	4	570	c.219C>T	c.(217-219)CAC>CAT	p.H73H	FAM193A_uc010ick.2_Silent_p.H273H|FAM193A_uc003gfd.2_Silent_p.H73H|FAM193A_uc011bvm.1_Silent_p.H73H|FAM193A_uc011bvn.1_Silent_p.H73H|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	73										ovary(3)	3						ATAATAAACACCTGTTTGAAA	0.398													20	86					0	0	0	0	T	2641515	T	T	2641515	2	4	48	1	0	0	0	0	0	0	0	1	5552	506	18	4		4	FAM193A	4	2641515	Silent	SNP	C	TCGA-CN-4737-01A-01D-1434-08		2641515	188512761	17	9708											
PROM1	8842	broad.mit.edu	37	chr4	16035066	16035066	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aaagaaataccccaccagagGcatcagaataataaacagca	21	4	6	10	0	1	3	1	0	0	3	1	3	1	3	3	1	3	2	3	1	7	3			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:16035066G>A	uc003goo.2	-	4	582	c.370C>T	c.(370-372)CCT>TCT	p.P124S	PROM1_uc003gor.2_Missense_Mutation_p.P124S|PROM1_uc003gos.2_Missense_Mutation_p.P115S|PROM1_uc003got.2_Missense_Mutation_p.P124S|PROM1_uc003gou.2_Missense_Mutation_p.P115S|PROM1_uc003gop.2_Missense_Mutation_p.P115S|PROM1_uc003goq.3_Missense_Mutation_p.P115S|PROM1_uc010iec.1_Missense_Mutation_p.P2S	NM_006017	NP_006008	O43490	PROM1_HUMAN	prominin 1 isoform 1	124	Helical; (Potential).				camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7						CCCACCAGAGGCATCAGAATA	0.428													7	35					0	0	0	0	A	16035066	A	A	16035066	3	1	48	1	0	0	0	0	1	0	0	0	12617	1203	42	4	2319	4	PROM1	4	16035066	Missense_Mutation	SNP	G	TCGA-CN-4737-01A-01D-1434-08	13393551	16035066	175119210	18	9709											
EPHA5	2044	broad.mit.edu	37	chr4	66270139	66270139	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgccaacaaaatgactccCactgtcacagacacagcaat	16	6	5	14	0	1	2	1	1	0	1	2	2	2	2	2	0	3	1	2	0	4	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:66270139C>T	uc003hcy.2	-	8	1936	c.1743G>A	c.(1741-1743)GTG>GTA	p.V581V	EPHA5_uc003hcx.2_Silent_p.V513V|EPHA5_uc003hcz.2_Silent_p.V581V|EPHA5_uc011cah.1_Silent_p.V582V|EPHA5_uc011cai.1_Silent_p.V582V|EPHA5_uc003hda.2_Silent_p.V582V	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	581	Helical; (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AAATGACTCCCACTGTCACAG	0.473										TSP Lung(17;0.13)			10	100					0	0	0	0	T	66270139	T	T	66270139	2	4	48	1	0	0	0	0	0	0	0	1	5194	581	21	4		4	EPHA5	4	66270139	Silent	SNP	C	TCGA-CN-4737-01A-01D-1434-08	50235073	66270139	124884137	19	9710											
GC	2638	broad.mit.edu	37	chr4	72618359	72618359	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaattttgcttttagtcgcTctgccagtctgaaaaaccat	10	14	7	10	1	2	1	0	1	2	0	3	1	2	1	2	0	3	3	2	0	4	4			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:72618359T>C	uc003hge.2	-	11	1424	c.1271A>G	c.(1270-1272)GAG>GGG	p.E424G	GC_uc003hgd.2_Missense_Mutation_p.E302G|GC_uc010iie.2_Missense_Mutation_p.E424G|GC_uc010iif.2_Missense_Mutation_p.E443G	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	424	Albumin 3.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TTTTAGTCGCTCTGCCAGTCT	0.373													18	157					0	0	0	0	C	72618359	C	C	72618359	3	2	48	1	0	0	0	0	1	0	0	0	6317	1551	54	5	161	5	GC	4	72618359	Missense_Mutation	SNP	T	TCGA-CN-4737-01A-01D-1434-08	6348220	72618359	118535917	20	9711											
SHROOM3	57619	broad.mit.edu	37	chr4	77675899	77675899	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaacgaggaagagggtctcGctgcctcagtggccacctcc	8	6	14	13	2	2	1	1	0	1	1	4	4	3	3	4	4	2	1	4	4	2	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:77675899G>A	uc011cbx.1	+	7	5216	c.4263G>A	c.(4261-4263)TCG>TCA	p.S1421S	SHROOM3_uc003hkg.2_Silent_p.S1199S	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1421					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			AGAGGGTCTCGCTGCCTCAGT	0.607													13	61					0	0	0	0	A	77675899	A	A	77675899	2	1	48	1	0	0	0	0	0	0	0	1	14360	1074	38	1		1	SHROOM3	4	77675899	Silent	SNP	G	TCGA-CN-4737-01A-01D-1434-08	5057540	77675899	113478377	21	9712											
FAT1	2195	broad.mit.edu	37	chr4	187518256	187518256	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttgcagtgataggagccGtgcgtgttctcacagagggc	8	9	15	9	2	1	2	1	1	1	1	2	3	1	3	1	2	3	3	1	2	1	3			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:187518256G>A	uc003izf.2	-	25	12626	c.12438C>T	c.(12436-12438)CAC>CAT	p.H4146H	FAT1_uc010isn.2_5'Flank|FAT1_uc003ize.2_Silent_p.H37H	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4146	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GATAGGAGCCGTGCGTGTTCT	0.587										HNSCC(5;0.00058)			10	50					0	0	0	0	A	187518256	A	A	187518256	2	1	48	1	0	0	0	0	0	0	0	1	5721	1136	40	1		1	FAT1	4	187518256	Silent	SNP	G	TCGA-CN-4737-01A-01D-1434-08	109842357	187518256	3636020	22	9713											
KIF4B	285643	broad.mit.edu	37	chr5	154394335	154394335	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attctctaggaggtaacagcCacactcttatgatagcctgt	11	12	8	10	0	2	1	0	1	2	0	3	2	2	2	2	2	3	1	2	2	4	5			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr5:154394335C>G	uc010jih.1	+	1	1076	c.916C>G	c.(916-918)CAC>GAC	p.H306D		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	306	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGGTAACAGCCACACTCTTAT	0.438													57	175					0	0	0	0	G	154394335	G	G	154394335	3	3	48	1	0	0	0	0	1	0	0	0	8343	594	21	4	918	4	KIF4B	5	154394335	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08		154394335	26520925	23	9714											
EXOC2	55770	broad.mit.edu	37	chr6	564672	564672	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctccgcgggtaagcttcaCcagggagtgcattacttcct	7	10	12	12	2	1	0	1	0	0	0	3	1	3	1	3	3	3	4	3	3	2	4			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr6:564672C>T	uc003mtd.2	-	15	1674	c.1540G>A	c.(1540-1542)GTG>ATG	p.V514M	EXOC2_uc003mte.2_Missense_Mutation_p.V514M|EXOC2_uc011dho.1_Missense_Mutation_p.V109M	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	514					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		GTAAGCTTCACCAGGGAGTGC	0.507													16	94					0	0	0	0	T	564672	T	T	564672	3	4	48	1	0	0	0	0	1	0	0	0	5326	507	18	4	1290	4	EXOC2	6	564672	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08		564672	170550395	24	9715											
PKHD1	5314	broad.mit.edu	37	chr6	51927390	51927390	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaatctgccacctgtaccCtggggtggcttcagtcagtt	7	11	11	12	0	3	0	2	0	1	0	3	1	3	0	3	3	2	3	3	3	2	3			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr6:51927390C>T	uc003pah.1	-	14	1321	c.1045G>A	c.(1045-1047)GGG>AGG	p.G349R	PKHD1_uc003pai.2_Missense_Mutation_p.G349R	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	349	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CACCTGTACCCTGGGGTGGCT	0.478													44	209					0	0	0	0	T	51927390	T	T	51927390	3	4	48	1	0	0	0	0	1	0	0	0	12026	681	24	4	11434	4	PKHD1	6	51927390	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	51362718	51927390	119187677	25	9716											
ENPP3	5169	broad.mit.edu	37	chr6	132006590	132006590	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacatgtacgaagggcctGccccccgcatccgagctcat	8	8	9	16	3	2	0	1	0	1	0	3	2	3	0	5	1	4	3	5	1	3	2			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr6:132006590G>T	uc003qcu.3	+	14	1554	c.1207G>T	c.(1207-1209)GCC>TCC	p.A403S	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.A403S	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	403	Extracellular (Potential).|Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CGAAGGGCCTGCCCCCCGCAT	0.363													51	269					2.41709e-19	2.65208e-19	1	0	T	132006590	T	T	132006590	3	4	48	1	0	0	0	0	1	0	0	0	5155	1319	46	4	1257	4	ENPP3	6	132006590	Missense_Mutation	SNP	G	TCGA-CN-4737-01A-01D-1434-08	80079200	132006590	39108477	26	9717											
SYNE1	23345	broad.mit.edu	37	chr6	152660381	152660381	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttttcattttcttaccgtttGctctgtttgttgaatgtctt	4	24	6	7	1	4	1	1	1	3	0	4	1	4	1	1	0	2	4	1	0	2	9			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr6:152660381G>T	uc010kiw.2	-	75	12948	c.12346C>A	c.(12346-12348)CAA>AAA	p.Q4116K	SYNE1_uc003qot.3_Missense_Mutation_p.Q4045K|SYNE1_uc003qou.3_Missense_Mutation_p.Q4116K|SYNE1_uc010kja.1_Missense_Mutation_p.Q821K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4116	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTACCGTTTGCTCTGTTTGT	0.378										HNSCC(10;0.0054)			32	70					1.99505e-19	2.21985e-19	1	0	T	152660381	T	T	152660381	3	4	48	1	0	0	0	0	1	0	0	0	15511	1328	46	4	14408	4	SYNE1	6	152660381	Missense_Mutation	SNP	G	TCGA-CN-4737-01A-01D-1434-08	20653791	152660381	18454686	27	9718											
RBAK	57786	broad.mit.edu	37	chr7	5104738	5104738	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtggaaagttattcaatgagTtgtcatactatactgaacat	14	14	8	5	0	2	2	2	2	0	0	2	3	2	3	0	1	3	2	0	1	7	6			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr7:5104738T>C	uc010kss.1	+	6	1975	c.1651T>C	c.(1651-1653)TTG>CTG	p.L551L	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Silent_p.L551L	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	551	Interaction with AR.|C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		ATTCAATGAGTTGTCATACTA	0.388													16	112					0	0	0	0	C	5104738	C	C	5104738	2	2	48	1	0	0	0	0	0	0	0	1	13165	1722	60	5		5	RBAK	7	5104738	Silent	SNP	T	TCGA-CN-4737-01A-01D-1434-08		5104738	154033925	28	9719											
RNF216	54476	broad.mit.edu	37	chr7	5662726	5662726	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggctgtggcaggttctgcGgaacgggcctcgggagggcc	4	7	20	10	3	1	0	0	0	1	0	2	2	1	2	2	7	2	3	2	7	1	1			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr7:5662726G>A	uc003soy.1	-	17	2556	c.2366C>T	c.(2365-2367)CCG>CTG	p.P789L	RNF216_uc010ksz.1_Missense_Mutation_p.P411L|RNF216_uc010kta.1_Missense_Mutation_p.P411L|RNF216_uc011jwj.1_Missense_Mutation_p.P411L|RNF216_uc003sox.1_Missense_Mutation_p.P846L	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	789	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		CAGGTTCTGCGGAACGGGCCT	0.627													13	75					0	0	0	0	A	5662726	A	A	5662726	3	1	48	1	0	0	0	0	1	0	0	0	13545	1116	39	1	238	1	RNF216	7	5662726	Missense_Mutation	SNP	G	TCGA-CN-4737-01A-01D-1434-08	557988	5662726	153475937	29	9720											
SRRT	51593	broad.mit.edu	37	chr7	100484755	100484755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	accccaacgaggacgagatgCccaatcgctgtgggatcatc	11	6	11	13	3	1	1	1	0	0	1	3	5	1	3	3	2	2	1	3	2	2	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr7:100484755C>T	uc003uwy.2	+	16	2177	c.1909C>T	c.(1909-1911)CCC>TCC	p.P637S	SRRT_uc010lhl.1_Missense_Mutation_p.P636S|SRRT_uc003uxa.2_Missense_Mutation_p.P636S|SRRT_uc003uwz.2_Missense_Mutation_p.P637S	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	637					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GGACGAGATGCCCAATCGCTG	0.572													5	283					0	0	0	0	T	100484755	T	T	100484755	3	4	48	1	0	0	0	0	1	0	0	0	15238	739	26	4	1963	4	SRRT	7	100484755	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	94822029	100484755	58653908	30	9721											
CHD7	55636	broad.mit.edu	37	chr8	61765872	61765872	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaagaggaagaagaaacCgatggcagcgggaaggagag	19	1	17	4	2	0	5	0	0	0	5	0	9	0	7	1	4	2	1	1	4	6	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr8:61765872C>T	uc003xue.2	+	31	7065	c.6588C>T	c.(6586-6588)ACC>ACT	p.T2196T		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2196	Glu-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AAGAAGAAACCGATGGCAGCG	0.532													8	60					0	0	0	0	T	61765872	T	T	61765872	2	4	48	1	0	0	0	0	0	0	0	1	3345	639	23	1		1	CHD7	8	61765872	Silent	SNP	C	TCGA-CN-4737-01A-01D-1434-08		61765872	84598150	31	9722											
DCAF4L2	138009	broad.mit.edu	37	chr8	88885104	88885104	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggcgagaagagaaggccaCactgggaatgtcgttctccg	11	6	15	9	3	1	2	0	0	1	2	3	6	1	3	2	3	0	1	2	3	3	1			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr8:88885104C>T	uc003ydz.2	-	1	1193	c.1096G>A	c.(1096-1098)GTG>ATG	p.V366M		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	366										ovary(1)	1						GAGAAGGCCACACTGGGAATG	0.592													19	183					0	0	0	0	T	88885104	T	T	88885104	3	4	48	1	0	0	0	0	1	0	0	0	4289	478	17	4	95	4	DCAF4L2	8	88885104	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	27119232	88885104	57478918	32	9723											
KIAA1539	80256	broad.mit.edu	37	chr9	35107972	35107972	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggtccctctgggcctaagagCcccacagtagatggttcttc	7	10	11	13	0	2	2	0	0	2	2	4	2	3	2	4	3	1	2	4	3	2	4			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr9:35107972C>T	uc003zwl.2	-	3	625	c.300G>A	c.(298-300)GGG>GGA	p.G100G	KIAA1539_uc003zwm.2_Silent_p.G100G|KIAA1539_uc003zwn.2_Intron|KIAA1539_uc003zwo.2_Silent_p.G100G|KIAA1539_uc003zwp.1_Silent_p.G100G|KIAA1539_uc010mkk.1_Intron	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	100						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GGCCTAAGAGCCCCACAGTAG	0.622													21	234					0	0	0	0	T	35107972	T	T	35107972	2	4	48	1	0	0	0	0	0	0	0	1	8281	726	26	4		4	KIAA1539	9	35107972	Silent	SNP	C	TCGA-CN-4737-01A-01D-1434-08		35107972	106105459	33	9724											
ZNF883	169834	broad.mit.edu	37	chr9	115759475	115759475	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactatgacaaaagacatcAccacacttagtacattgata	17	10	5	9	0	1	3	1	2	0	1	1	3	1	3	1	0	2	2	1	0	7	6			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr9:115759475A>G	uc011lwy.1	-	5	2304	c.1065T>C	c.(1063-1065)GGT>GGC	p.G355G		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	355	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAAGACATCACCACACTTAG	0.398													11	69					0	0	0	0	G	115759475	G	G	115759475	2	3	48	1	0	0	0	0	0	0	0	1	18265	146	6	5		5	ZNF883	9	115759475	Silent	SNP	A	TCGA-CN-4737-01A-01D-1434-08	80651503	115759475	25453956	34	9725											
COBRA1	25920	broad.mit.edu	37	chr9	140161436	140161436	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttcctcccgatgctcatgtCcttcctggtggatgactaca	6	13	9	13	1	1	1	1	1	0	0	5	3	5	2	4	2	2	2	4	2	1	3			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr9:140161436C>T	uc004cmm.3	+	9	1339	c.1136C>T	c.(1135-1137)TCC>TTC	p.S379F		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	379					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		ATGCTCATGTCCTTCCTGGTG	0.587													12	65					0	0	0	0	T	140161436	T	T	140161436	3	4	48	1	0	0	0	0	1	0	0	0	3670	855	30	2	1170	2	COBRA1	9	140161436	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	24401961	140161436	1051995	35	9726											
MRGPRX3	117195	broad.mit.edu	37	chr11	18159065	18159065	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcctgtgatgacctttcccTactttataggcctaagcatg	8	14	8	11	0	0	2	0	2	0	0	2	2	2	2	4	1	2	1	4	1	4	6			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr11:18159065T>C	uc001mnu.2	+	3	677	c.316T>C	c.(316-318)TAC>CAC	p.Y106H		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	106	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						GACCTTTCCCTACTTTATAGG	0.552													44	230					0	0	0	0	C	18159065	C	C	18159065	3	2	48	1	0	0	0	0	1	0	0	0	9821	1522	53	5	318	5	MRGPRX3	11	18159065	Missense_Mutation	SNP	T	TCGA-CN-4737-01A-01D-1434-08		18159065	116847451	36	9727											
HARBI1	283254	broad.mit.edu	37	chr11	46637146	46637146	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctatctttgtgcataccCgcttcaaactgactactgag	10	12	7	12	1	2	2	1	2	1	0	2	2	2	2	1	0	5	3	1	0	4	5			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr11:46637146C>A	uc001ncy.2	-	2	890	c.642G>T	c.(640-642)GCG>GCT	p.A214A	KIAA0652_uc009yld.2_5'Flank|KIAA0652_uc001nda.2_5'Flank|KIAA0652_uc001ndb.2_5'Flank|KIAA0652_uc001ncz.2_5'Flank|KIAA0652_uc001ndc.2_5'Flank|KIAA0652_uc010rgv.1_5'Flank	NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	214						cytoplasm|nucleus	metal ion binding|nuclease activity				0						TGTGCATACCCGCTTCAAACT	0.428													37	215					3.75037e-06	3.84779e-06	1	0	A	46637146	A	A	46637146	2	1	48	1	0	0	0	0	0	0	0	1	6997	639	23	3		3	HARBI1	11	46637146	Silent	SNP	C	TCGA-CN-4737-01A-01D-1434-08	28478081	46637146	88369370	37	9728											
MS4A10	341116	broad.mit.edu	37	chr11	60561573	60561573	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagaatgtaccccaactcCacggtgagtacccaggcctg	10	7	11	13	1	0	2	0	1	0	1	1	3	1	2	5	3	3	2	5	3	4	2			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr11:60561573C>A	uc001npz.1	+	5	585	c.489C>A	c.(487-489)TCC>TCA	p.S163S		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	163	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2						ACCCCAACTCCACGGTGAGTA	0.567													4	159					0.00909568	0.00921229	1	0	A	60561573	A	A	60561573	2	1	48	1	0	0	0	0	0	0	0	1	9908	581	21	4		4	MS4A10	11	60561573	Silent	SNP	C	TCGA-CN-4737-01A-01D-1434-08	13924427	60561573	74444943	38	9729											
NOP2	4839	broad.mit.edu	37	chr12	6666429	6666429	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagccggtgtttgtgtgtcTgtgcccttgggaggggcatt	4	13	16	8	1	1	0	0	0	1	0	1	1	1	1	2	4	2	2	2	4	0	3			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:6666429T>A	uc001qph.1	-	16	2337	c.2157A>T	c.(2155-2157)ACA>ACT	p.T719T	IFFO1_uc001qpe.1_5'Flank|IFFO1_uc010sfe.1_5'Flank|IFFO1_uc001qpf.1_5'Flank|IFFO1_uc001qpc.1_5'Flank|IFFO1_uc001qpd.1_5'Flank|NOP2_uc009zeq.1_3'UTR|NOP2_uc001qpi.1_Silent_p.T719T|NOP2_uc001qpj.1_Silent_p.T148T	NM_001033714	NP_001028886	P46087	NOP2_HUMAN	nucleolar protein 1, 120kDa	723					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						TTTGTGTGTCTGTGCCCTTGG	0.537													62	436					0	0	0	0	A	6666429	A	A	6666429	2	1	48	1	0	0	0	0	0	0	0	1	10592	1567	55	5		5	NOP2	12	6666429	Silent	SNP	T	TCGA-CN-4737-01A-01D-1434-08		6666429	127185466	39	9730											
SOX5	6660	broad.mit.edu	37	chr12	23689485	23689485	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatccaccaggcaggtgcgCtttggcctgggcttgtactt	5	11	12	13	1	0	0	0	0	0	0	1	0	1	0	4	4	2	4	4	4	1	4			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:23689485C>A	uc001rfw.2	-	14	1992	c.1890G>T	c.(1888-1890)AAG>AAT	p.K630N	SOX5_uc001rfx.2_Missense_Mutation_p.K617N|SOX5_uc001rfy.2_Missense_Mutation_p.K509N|SOX5_uc001rfv.2_Missense_Mutation_p.K244N|SOX5_uc010siv.1_Missense_Mutation_p.K617N|SOX5_uc010siw.1_RNA	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	630					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						GGCAGGTGCGCTTTGGCCTGG	0.517													33	136					1.22384e-17	1.32442e-17	1	0	A	23689485	A	A	23689485	3	1	48	1	0	0	0	0	1	0	0	0	15018	796	28	4	409	4	SOX5	12	23689485	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	17023056	23689485	110162410	40	9731											
MLL2	8085	broad.mit.edu	37	chr12	49425421	49425421	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcagcaggtgagaccctcCcaggaggcggctccaaggtt	9	5	14	13	1	0	1	0	1	0	1	2	3	2	2	3	5	2	4	3	5	1	1			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:49425421C>T	uc001rta.3	-	39	13067	c.13067G>A	c.(13066-13068)GGG>GAG	p.G4356E		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4356	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGAGACCCTCCCAGGAGGCGG	0.622			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			3	26					0	0	0	0	T	49425421	T	T	49425421	3	4	48	1	0	0	0	0	1	0	0	0	9674	623	22	4	3610	4	MLL2	12	49425421	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	25735936	49425421	84426474	41	9732											
PTPRB	5787	broad.mit.edu	37	chr12	70956847	70956847	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggaaggacaggtgcctggtGgagttctctgtgatcctcag	7	10	15	9	1	2	1	1	1	1	0	4	4	3	4	2	5	1	1	2	5	1	1			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:70956847G>A	uc001swb.3	-	14	3321	c.3291C>T	c.(3289-3291)TCC>TCT	p.S1097S	PTPRB_uc010sto.1_Silent_p.S1007S|PTPRB_uc010stp.1_Silent_p.S1007S|PTPRB_uc001swc.3_Silent_p.S1315S|PTPRB_uc001swa.3_Silent_p.S1227S|PTPRB_uc001swd.3_Silent_p.S1314S|PTPRB_uc009zrr.1_Silent_p.S1194S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1097	Fibronectin type-III 13.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGTGCCTGGTGGAGTTCTCTG	0.562													4	47					0	0	0	0	A	70956847	A	A	70956847	2	1	48	1	0	0	0	0	0	0	0	1	12861	1335	47	4		4	PTPRB	12	70956847	Silent	SNP	G	TCGA-CN-4737-01A-01D-1434-08	21531426	70956847	62895048	42	9733											
ACACB	32	broad.mit.edu	37	chr12	109610133	109610133	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaccctaaacttccggagctGctgtgcaagaatggagttgc	11	9	11	10	1	0	1	0	0	0	1	1	3	1	3	2	2	6	4	2	2	5	3			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:109610133G>A	uc001tob.2	+	6	1208	c.1089G>A	c.(1087-1089)CTG>CTA	p.L363L	ACACB_uc001toc.2_Silent_p.L363L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	363	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TTCCGGAGCTGCTGTGCAAGA	0.512													127	300					0	0	0	0	A	109610133	A	A	109610133	2	1	48	1	0	0	0	0	0	0	0	1	107	1306	46	4		4	ACACB	12	109610133	Silent	SNP	G	TCGA-CN-4737-01A-01D-1434-08	38653286	109610133	24241762	43	9734											
USPL1	10208	broad.mit.edu	37	chr13	31205139	31205139	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaattatattgctattgaCggtggaaaagttttgaacag	15	13	10	3	1	0	3	0	2	0	1	0	4	0	4	0	2	2	2	0	2	7	7			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr13:31205139C>T	uc001utc.2	+	4	828	c.396C>T	c.(394-396)GAC>GAT	p.D132D	USPL1_uc001utb.2_Translation_Start_Site|USPL1_uc001utd.2_Intron	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	132					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		TTGCTATTGACGGTGGAAAAG	0.368													24	49					0	0	0	0	T	31205139	T	T	31205139	2	4	48	1	0	0	0	0	0	0	0	1	17160	535	19	1		1	USPL1	13	31205139	Silent	SNP	C	TCGA-CN-4737-01A-01D-1434-08		31205139	83964739	44	9735											
LCP1	3936	broad.mit.edu	37	chr13	46701815	46701815	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccaggtcttctggcagggCatacactcttgctccaattt	9	12	8	12	0	3	0	0	0	3	0	4	0	4	0	2	3	3	3	2	3	3	4			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr13:46701815C>G	uc001vaz.3	-	16	1921	c.1795G>C	c.(1795-1797)GCC>CCC	p.A599P	LCP1_uc010ack.2_Missense_Mutation_p.A168P|LCP1_uc001vay.3_Missense_Mutation_p.A196P|LCP1_uc001vba.3_Missense_Mutation_p.A599P	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	599	Actin-binding 2.|CH 4.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TCTGGCAGGGCATACACTCTT	0.488			T	BCL6	NHL 								10	294					0	0	0	0	G	46701815	G	G	46701815	3	3	48	1	0	0	0	0	1	0	0	0	8731	710	25	4	92	4	LCP1	13	46701815	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	15496676	46701815	68468063	45	9736											
TEP1	7011	broad.mit.edu	37	chr14	20854732	20854732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcagcagcaggtcccgctccCcatgcatgtctcggaaagtg	8	8	11	14	2	2	0	1	0	1	0	5	1	4	1	3	2	3	4	3	2	1	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr14:20854732C>T	uc001vxe.2	-	19	2775	c.2735G>A	c.(2734-2736)GGG>GAG	p.G912E	TEP1_uc010ahk.2_Missense_Mutation_p.G262E|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.G804E	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	912					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GTCCCGCTCCCCATGCATGTC	0.622													9	28					0	0	0	0	T	20854732	T	T	20854732	3	4	48	1	0	0	0	0	1	0	0	0	15825	623	22	4	5296	4	TEP1	14	20854732	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08		20854732	86494808	46	9737											
BCL11B	64919	broad.mit.edu	37	chr14	99641386	99641386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccacgttctccatgaccttgCccagcaccagcgccttctcg	6	9	7	19	3	2	1	0	1	2	0	4	1	2	1	6	0	3	2	6	0	0	3			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr14:99641386C>T	uc001yga.2	-	4	2054	c.1787G>A	c.(1786-1788)GGC>GAC	p.G596D	BCL11B_uc001ygb.2_Missense_Mutation_p.G525D	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	596	Gly-rich.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CATGACCTTGCCCAGCACCAG	0.542			T	TLX3	T-ALL								9	61					0	0	0	0	T	99641386	T	T	99641386	3	4	48	1	0	0	0	0	1	0	0	0	1366	739	26	4	901	4	BCL11B	14	99641386	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	78786654	99641386	7708154	47	9738											
LINS1	55180	broad.mit.edu	37	chr15	101120660	101120660	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcttactaatttagaatCgactttggctgattctaaga	12	15	8	6	1	1	3	0	1	1	2	2	4	1	3	0	2	1	2	0	2	5	7			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr15:101120660C>A	uc002bwe.2	-	3	679	c.388G>T	c.(388-390)GAT>TAT	p.D130Y	LINS1_uc002bwf.2_Missense_Mutation_p.D130Y|LINS1_uc002bwg.2_Missense_Mutation_p.D130Y|LINS1_uc002bwh.2_Missense_Mutation_p.D130Y|LINS1_uc010usa.1_Intron|LINS1_uc002bwi.2_Missense_Mutation_p.D130Y	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	130											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			AATTTAGAATCGACTTTGGCT	0.313													13	81					9.05144e-12	9.66303e-12	1	0	A	101120660	A	A	101120660	3	1	48	1	0	0	0	0	1	0	0	0	8860	884	31	3	1909	3	LINS1	15	101120660	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08		101120660	1410732	48	9739											
ARMC5	79798	broad.mit.edu	37	chr16	31477726	31477726	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccgcctcccctttcttccGggccctgctgtcaggcagct	3	10	9	19	2	2	0	1	0	1	0	4	0	4	0	6	2	2	3	6	2	0	2			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr16:31477726G>A	uc002ecc.2	+	6	2853	c.2324G>A	c.(2323-2325)CGG>CAG	p.R775Q	ARMC5_uc010vfn.1_Missense_Mutation_p.R870Q|ARMC5_uc010vfo.1_Missense_Mutation_p.R807Q|ARMC5_uc002eca.3_3'UTR|ARMC5_uc010vfp.1_Missense_Mutation_p.R583Q|ARMC5_uc002ecb.2_3'UTR	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	775	BTB.						binding			pancreas(1)	1						CCTTTCTTCCGGGCCCTGCTG	0.667													8	30					0	0	0	0	A	31477726	A	A	31477726	3	1	48	1	0	0	0	0	1	0	0	0	956	1116	39	1	2660	1	ARMC5	16	31477726	Missense_Mutation	SNP	G	TCGA-CN-4737-01A-01D-1434-08		31477726	58877027	49	9740											
TP53	7157	broad.mit.edu	37	chr17	7578427	7578427	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcacaacctccgtcatgTgctgtgactgcttgtagatg	7	12	10	12	1	2	2	2	1	0	1	3	2	3	2	3	0	3	3	3	0	2	2			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr17:7578427T>A	uc002gim.2	-	5	697	c.503A>T	c.(502-504)CAC>CTC	p.H168L	TP53_uc002gig.1_Missense_Mutation_p.H168L|TP53_uc002gih.2_Missense_Mutation_p.H168L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H36L|TP53_uc010cng.1_Missense_Mutation_p.H36L|TP53_uc002gii.1_Missense_Mutation_p.H36L|TP53_uc010cnh.1_Missense_Mutation_p.H168L|TP53_uc010cni.1_Missense_Mutation_p.H168L|TP53_uc002gij.2_Missense_Mutation_p.H168L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H75L|TP53_uc002gio.2_Missense_Mutation_p.H36L|TP53_uc010vug.1_Missense_Mutation_p.H129L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	168	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		QH -> HD (in a sporadic cancer; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|HM -> LI (in a sporadic cancer; somatic mutation).|QH -> YL (in a sporadic cancer; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> V (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|H -> R (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H168R(12)|p.H168P(9)|p.H168Y(9)|p.0?(7)|p.H168L(5)|p.H168H(4)|p.H168fs*2(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.Y163fs*1(1)|p.P151_V173del23(1)|p.S149fs*72(1)|p.H168_M169>LI(1)|p.H168fs*13(1)|p.H168fs*5(1)|p.H168Q(1)|p.H168fs*69(1)|p.Q167fs*12(1)|p.H168D(1)|p.Q167_H168>HD(1)|p.H168N(1)|p.Q167_H168>YL(1)|p.H168fs*3(1)|p.H168fs*4(1)|p.Q165_M169delQSQHM(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCCGTCATGTGCTGTGACTG	0.652		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	48					0	0	0	0	A	7578427	A	A	7578427	3	1	48	1	0	0	0	0	1	0	0	0	16448	1696	59	5	795	5	TP53	17	7578427	Missense_Mutation	SNP	T	TCGA-CN-4737-01A-01D-1434-08		7578427	73616783	50	9741											
MFSD6L	162387	broad.mit.edu	37	chr17	8701070	8701070	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagatctgaatggggaggaCggaccaccagctccagagga	13	4	14	10	1	1	3	0	1	1	2	2	7	2	7	3	5	1	1	3	5	2	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr17:8701070C>T	uc002glp.1	-	1	1517	c.1369G>A	c.(1369-1371)GTC>ATC	p.V457I		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	457	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						ATGGGGAGGACGGACCACCAG	0.612													35	128					0	0	0	0	T	8701070	T	T	8701070	3	4	48	1	0	0	0	0	1	0	0	0	9589	536	19	1	395	1	MFSD6L	17	8701070	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	1122643	8701070	72494140	51	9742											
TTC25	83538	broad.mit.edu	37	chr17	40117329	40117329	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaaatttataggaggccttCgggagaattagagcaaagac	16	8	12	5	1	0	4	0	0	0	4	1	6	0	5	1	3	1	1	1	3	6	5			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr17:40117329C>T	uc002hyj.3	+	11	1936	c.1847C>T	c.(1846-1848)TCG>TTG	p.S616L	TTC25_uc010cxt.2_RNA|CNP_uc002hyk.1_5'Flank|CNP_uc002hyl.1_5'Flank|CNP_uc010wfz.1_5'Flank|CNP_uc002hym.1_5'Flank|CNP_uc010wga.1_5'Flank	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	616						cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				AGGAGGCCTTCGGGAGAATTA	0.463													7	30					0	0	0	0	T	40117329	T	T	40117329	3	4	48	1	0	0	0	0	1	0	0	0	16761	893	31	1	1697	1	TTC25	17	40117329	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08	31416259	40117329	41077881	52	9743											
KIF18B	146909	broad.mit.edu	37	chr17	43012716	43012719	+	Frame_Shift_Del	DEL	TGCC	-	-																															cacggtggtcaggtacatgaTgccggggtccccctcccttc																										TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr17:43012716_43012719delTGCC	uc010wji.1	-	3	480_483	c.379_382delGGCA	c.(379-384)GGCATCfs	p.G127fs	KIF18B_uc002iht.2_Frame_Shift_Del_p.G127fs|KIF18B_uc010wjh.1_Frame_Shift_Del_p.G127fs	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				AGGTACATGATGCCGGGGTCCCCC	0.637													---	---	---								-	43012719	-	-	43012716	7	5	48	1	0	1	0	1	0	0	0	0	8320	1464	51	0	2240	0	KIF18B	17	43012716	Frame_Shift_Del	DEL	TGCC	TCGA-CN-4737-01A-01D-1434-08	2895387	43012716	38182494	53	9744											
MYOM1	8736	broad.mit.edu	37	chr18	3215034	3215034	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaggaggaggcggacgccCgacggaaggcctcggactcc	8	2	19	12	5	0	0	0	0	0	0	2	7	1	6	3	8	0	0	3	8	1	0			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr18:3215034C>T	uc002klp.2	-	2	522	c.188G>A	c.(187-189)CGG>CAG	p.R63Q	MYOM1_uc002klq.2_Missense_Mutation_p.R63Q	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	63						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GGCGGACGCCCGACGGAAGGC	0.687													11	33					0	0	0	0	T	3215034	T	T	3215034	3	4	48	1	0	0	0	0	1	0	0	0	10144	652	23	1	5017	1	MYOM1	18	3215034	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08		3215034	74862214	54	9745											
LMNB2	84823	broad.mit.edu	37	chr19	2434446	2434446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttggcgtccagcatcttcCggaacttgtcccgctccccg	4	10	9	18	4	1	0	0	0	1	0	5	1	5	1	6	2	2	2	6	2	1	3			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr19:2434446C>T	uc002lvy.2	-	7	1076	c.989G>A	c.(988-990)CGG>CAG	p.R330Q	LMNB2_uc002lwa.1_Missense_Mutation_p.R350Q	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	330	Rod.|Coil 2.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCATCTTCCGGAACTTGTC	0.667													6	77					0	0	0	0	T	2434446	T	T	2434446	3	4	48	1	0	0	0	0	1	0	0	0	8892	652	23	1	837	1	LMNB2	19	2434446	Missense_Mutation	SNP	C	TCGA-CN-4737-01A-01D-1434-08		2434446	56694537	55	9746											
ZNF676	163223	broad.mit.edu	37	chr19	22362786	22362786	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtatgaattttcttatgaTaactaacagttgaggatgac	14	14	8	5	0	1	4	0	4	1	0	1	5	1	5	0	1	2	2	0	1	5	7			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr19:22362786T>A	uc002nqs.1	-	3	2051	c.1733A>T	c.(1732-1734)TAT>TTT	p.Y578F		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	578	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TTTCTTATGATAACTAACAGT	0.353													14	98					0	0	0	0	A	22362786	A	A	22362786	3	1	48	1	0	0	0	0	1	0	0	0	18150	1406	49	5	37	5	ZNF676	19	22362786	Missense_Mutation	SNP	T	TCGA-CN-4737-01A-01D-1434-08	19928340	22362786	36766197	56	9747											
ZNF611	81856	broad.mit.edu	37	chr19	53208627	53208638	+	In_Frame_Del	DEL	TATGAATTCTAG	-	-																															cttgtaaggtttctctccacTatgaattctagtatgttttg																								rs151210254	by1000genomes	TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr19:53208627_53208638delTATGAATTCTAG	uc002pzz.2	-	7	1987_1998	c.1670_1681delCTAGAATTCATA	c.(1669-1683)ACTAGAATTCATAGT>AGT	p.TRIH557del	ZNF611_uc010eqc.2_In_Frame_Del_p.TRIH487del|ZNF611_uc010ydo.1_In_Frame_Del_p.TRIH487del|ZNF611_uc010ydr.1_In_Frame_Del_p.TRIH488del|ZNF611_uc010ydp.1_In_Frame_Del_p.TRIH557del|ZNF611_uc010ydq.1_In_Frame_Del_p.TRIH557del|ZNF611_uc002qaa.3_In_Frame_Del_p.TRIH487del	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	557_560	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TTCTCTCCACTATGAATTCTAGTATGTTTTGC	0.406													---	---	---								-	53208638	-	-	53208627	7	5	48	1	0	1	0	1	0	0	0	0	18104	1522	53	0	440	0	ZNF611	19	53208627	In_Frame_Del	DEL	TATGAATTCTAG	TCGA-CN-4737-01A-01D-1434-08	30845841	53208627	5920356	57	9748											
GZF1	64412	broad.mit.edu	37	chr20	23350773	23350773	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtctttccttgtcattgtaGatggctcgcccaagaacgat	9	13	9	10	2	2	2	1	0	1	2	4	3	3	2	2	1	1	2	2	1	3	4			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr20:23350773G>A	uc010gdb.2	+	7	2005	c.1831G>A	c.(1831-1833)GAT>AAT	p.D611N	GZF1_uc002wsy.2_Missense_Mutation_p.D611N|GZF1_uc010zsq.1_Missense_Mutation_p.D135N|GZF1_uc010zsr.1_Missense_Mutation_p.D120N|GZF1_uc002wsz.2_Missense_Mutation_p.D611N	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	611					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					TGTCATTGTAGATGGCTCGCC	0.418													30	67					0	0	0	0	A	23350773	A	A	23350773	3	1	48	1	0	0	0	0	1	0	0	0	6953	942	33	2	1849	2	GZF1	20	23350773	Missense_Mutation	SNP	G	TCGA-CN-4737-01A-01D-1434-08		23350773	39674747	58	9749											
UBE4B	10277	broad.mit.edu	37	chr1	10207077	10207077	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacttgacgagagcttcctGagaagatgtctgaattttta	11	14	9	7	1	1	5	0	3	1	3	2	7	2	5	1	0	2	1	1	0	4	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:10207077G>A	uc001aqs.3	+	19	3233	c.2520G>A	c.(2518-2520)CTG>CTA	p.L840L	UBE4B_uc001aqr.3_Silent_p.L711L|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Silent_p.L295L|UBE4B_uc001aqt.1_Silent_p.L180L	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	840					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		AGAGCTTCCTGAGAAGATGTC	0.527													17	113					0	0	0	0	A	10207077	A	A	10207077	2	1	49	1	0	0	0	0	0	0	0	1	16951	1277	45	2		2	UBE4B	1	10207077	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08		10207077	239043544	1	9750											
ZNF436	80818	broad.mit.edu	37	chr1	23688996	23688996	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggactcgatagtgtttgatGagatcagatctctcactgaa	11	13	10	7	1	3	4	2	3	1	2	5	7	3	5	0	1	0	1	0	1	2	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:23688996G>A	uc001bgt.2	-	3	1260	c.879C>T	c.(877-879)CTC>CTT	p.L293L	ZNF436_uc001bgu.2_Silent_p.L293L	NM_030634	NP_085137	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	293	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		AGTGTTTGATGAGATCAGATC	0.527													14	144					0	0	0	0	A	23688996	A	A	23688996	2	1	49	1	0	0	0	0	0	0	0	1	17976	1277	45	2		2	ZNF436	1	23688996	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	13481919	23688996	225561625	2	9751											
PTPRU	10076	broad.mit.edu	37	chr1	29644357	29644358	+	Missense_Mutation	DNP	CG	TC	TC																															ccgcagcatggacgtcctgcCgcccgaccgctgcctgccct																										TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:29644357_29644358CG>TC	uc001bru.2	+	26	3751_3752	c.3641_3642CG>TC	c.(3640-3642)CCG>CTC	p.P1214L	PTPRU_uc001brv.2_Missense_Mutation_p.P1210L|PTPRU_uc001brw.2_Missense_Mutation_p.P1204L|PTPRU_uc009vtq.2_Missense_Mutation_p.P1210L|PTPRU_uc009vtr.2_Missense_Mutation_p.P1201L|PTPRU_uc001brx.2_5'Flank	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1214	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GACGTCCTGCCGCCCGACCGCT	0.629													12	64					0	0	0	0	TC	29644358	TC	TC	29644357	3	4	49	1	0	0	0	0	1	0	0	0	12878	652	23	1	3765	1	PTPRU	1	29644357	Missense_Mutation	DNP	CG	TCGA-CN-4738-01A-02D-1512-08	5955361	29644357	219606264	3	9752											
CCDC24	149473	broad.mit.edu	37	chr1	44461305	44461305	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaggagtatttgaggccttgCcacccctctgaggcagccct	7	9	12	13	0	1	2	0	2	1	0	1	4	1	3	5	3	2	2	5	3	1	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:44461305C>T	uc001clj.2	+	7	756	c.585C>T	c.(583-585)TGC>TGT	p.C195C	SLC6A9_uc009vxe.2_Intron|SLC6A9_uc010okm.1_Intron|CCDC24_uc001clk.2_Silent_p.C150C|CCDC24_uc009vxc.2_Silent_p.C159C	NM_152499	NP_689712	Q8N4L8	CCD24_HUMAN	coiled-coil domain containing 24	195	Potential.										0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TGAGGCCTTGCCACCCCTCTG	0.647													3	25					0	0	0	0	T	44461305	T	T	44461305	2	4	49	1	0	0	0	0	0	0	0	1	2812	747	26	4		4	CCDC24	1	44461305	Silent	SNP	C	TCGA-CN-4738-01A-02D-1512-08	14816948	44461305	204789316	4	9753											
HFM1	164045	broad.mit.edu	37	chr1	91781517	91781517	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatttctgccgtcgtatcacTatatcttgtaatctttaaaa	11	18	4	8	2	4	0	1	0	3	0	5	0	4	0	1	0	1	2	1	0	7	9			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:91781517T>A	uc001doa.3	-	28	3095	c.2995A>T	c.(2995-2997)AGT>TGT	p.S999C	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.S678C|HFM1_uc001dob.3_Missense_Mutation_p.S187C|HFM1_uc010osv.1_Missense_Mutation_p.S683C	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	999	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GTCGTATCACTATATCTTGTA	0.299													10	48					0	0	0	0	A	91781517	A	A	91781517	3	1	49	1	0	0	0	0	1	0	0	0	7122	1522	53	5	1360	5	HFM1	1	91781517	Missense_Mutation	SNP	T	TCGA-CN-4738-01A-02D-1512-08	47320212	91781517	157469104	5	9754											
GLMN	11146	broad.mit.edu	37	chr1	92713516	92713516	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggctttaagaaattattctCaatatttccaagttctgtcc	11	17	5	8	0	2	1	1	0	2	1	5	1	4	1	2	1	0	2	2	1	6	7			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:92713516C>T	uc001dor.2	-	17	1619	c.1504G>A	c.(1504-1506)GAG>AAG	p.E502K	GLMN_uc009wdg.2_RNA|GLMN_uc001dos.2_Missense_Mutation_p.E488K	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	502					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		AAATTATTCTCAATATTTCCA	0.234									Multiple_Glomus_Tumors_(of_the_Skin)_Familial				9	142					0	0	0	0	T	92713516	T	T	92713516	3	4	49	1	0	0	0	0	1	0	0	0	6485	835	29	2	292	2	GLMN	1	92713516	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	931999	92713516	156537105	6	9755											
LPPR4	9890	broad.mit.edu	37	chr1	99764696	99764696	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gactgtgtgcaaaccaaactAtacctctctgaatgtatctt	12	13	6	10	0	2	1	0	1	2	0	3	2	2	1	2	0	4	2	2	0	6	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:99764696A>G	uc001dse.2	+	4	750	c.644A>G	c.(643-645)TAT>TGT	p.Y215C	LPPR4_uc010oue.1_Missense_Mutation_p.Y215C	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	215							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AAACCAAACTATACCTCTCTG	0.393													8	94					0	0	0	0	G	99764696	G	G	99764696	3	3	49	1	0	0	0	0	1	0	0	0	8977	449	16	5	658	5	LPPR4	1	99764696	Missense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	7051180	99764696	149485925	7	9756											
TUFT1	7286	broad.mit.edu	37	chr1	151547445	151547445	+	Frame_Shift_Del	DEL	G	-	-																															ggtggccctagaggaacttcGgagcaacaatgctgactgcc																										TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:151547445delG	uc001eyl.2	+	9	844	c.782delG	c.(781-783)CGGfs	p.R261fs	TUFT1_uc001eym.2_Frame_Shift_Del_p.R236fs|TUFT1_uc010pdf.1_Frame_Shift_Del_p.R280fs|TUFT1_uc010pdg.1_Frame_Shift_Del_p.R209fs	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1	261	Potential.				bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GAGGAACTTCGGAGCAACAAT	0.547													---	---	---								-	151547445	-	-	151547445	7	5	49	1	0	1	0	1	0	0	0	0	16840	1116	39	0	816	0	TUFT1	1	151547445	Frame_Shift_Del	DEL	G	TCGA-CN-4738-01A-02D-1512-08	51782749	151547445	97703176	8	9757											
LINGO4	339398	broad.mit.edu	37	chr1	151774631	151774631	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcgctccagggtgagggTgctcaacttggctagccctg	6	8	15	12	1	1	1	1	1	0	0	2	1	2	1	2	3	4	4	2	3	2	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:151774631T>A	uc001ezf.1	-	2	740	c.550A>T	c.(550-552)ACC>TCC	p.T184S		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	184	Extracellular (Potential).|LRR 6.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGGGTGAGGGTGCTCAACTTG	0.607													17	88					0	0	0	0	A	151774631	A	A	151774631	3	1	49	1	0	0	0	0	1	0	0	0	8859	1696	59	5	1235	5	LINGO4	1	151774631	Missense_Mutation	SNP	T	TCGA-CN-4738-01A-02D-1512-08	227186	151774631	97475990	9	9758											
FLG2	388698	broad.mit.edu	37	chr1	152326395	152326395	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgtgtgtgaatgtgttcTgaatgtctgtgtgagacctt	6	17	13	5	0	2	3	0	3	2	1	2	4	2	3	1	0	0	2	1	0	2	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:152326395T>C	uc001ezw.3	-	3	3940	c.3867A>G	c.(3865-3867)TCA>TCG	p.S1289S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1289	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAATGTGTTCTGAATGTCTGT	0.468													51	314					0	0	0	0	C	152326395	C	C	152326395	2	2	49	1	0	0	0	0	0	0	0	1	5955	1567	55	5		5	FLG2	1	152326395	Silent	SNP	T	TCGA-CN-4738-01A-02D-1512-08	551764	152326395	96924226	10	9759											
OR6K6	128371	broad.mit.edu	37	chr1	158725011	158725011	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtactttttccactcacttGgtatcacagaaagctgtgtc	9	15	7	10	0	2	1	2	0	0	1	4	1	3	1	1	1	2	3	1	1	3	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:158725011G>A	uc001fsw.1	+	1	406	c.406G>A	c.(406-408)GGT>AGT	p.G136S		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	136	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					CCACTCACTTGGTATCACAGA	0.493													5	115					0	0	0	0	A	158725011	A	A	158725011	3	1	49	1	0	0	0	0	1	0	0	0	11258	1348	47	4	408	4	OR6K6	1	158725011	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	6398616	158725011	90525610	11	9760											
CACNA1S	779	broad.mit.edu	37	chr1	201044689	201044689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagggtaggacggcccgcCgtaggccatgatcccattgt	7	7	14	13	3	0	1	0	1	0	0	1	2	1	2	5	4	0	2	5	4	2	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:201044689C>T	uc001gvv.2	-	13	2109	c.1882G>A	c.(1882-1884)GGC>AGC	p.G628S		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	628	II.|Extracellular (Potential).			YG -> SS (in Ref. 1; AAA51902).|G -> R (in Ref. 2; AAB37235).	axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GACGGCCCGCCGTAGGCCATG	0.547													17	190					0	0	0	0	T	201044689	T	T	201044689	3	4	49	1	0	0	0	0	1	0	0	0	2559	652	23	1	3867	1	CACNA1S	1	201044689	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	42319678	201044689	48205932	12	9761											
GPATCH2	55105	broad.mit.edu	37	chr1	217793361	217793361	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcaggtggctgggtcattgtCcgtttgttagagatgtcctg	5	15	14	7	1	2	1	2	0	0	1	4	2	4	1	2	3	0	3	2	3	1	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:217793361C>T	uc001hlf.1	-	2	633	c.537G>A	c.(535-537)CGG>CGA	p.R179R	GPATCH2_uc001hlg.3_Silent_p.R179R	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	179						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		GGGTCATTGTCCGTTTGTTAG	0.448													28	186					0	0	0	0	T	217793361	T	T	217793361	2	4	49	1	0	0	0	0	0	0	0	1	6629	842	30	2		2	GPATCH2	1	217793361	Silent	SNP	C	TCGA-CN-4738-01A-02D-1512-08	16748672	217793361	31457260	13	9762											
PSEN2	5664	broad.mit.edu	37	chr1	227069674	227069674	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcggacgtccctaatgtcGgctgagagccccacgccgcg	7	5	14	15	6	0	1	0	1	0	1	2	4	1	2	4	2	2	1	4	2	1	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:227069674G>A	uc009xeo.1	+	4	493	c.66G>A	c.(64-66)TCG>TCA	p.S22S	PSEN2_uc009xep.1_Silent_p.S22S|PSEN2_uc001hqk.2_RNA	NM_000447	NP_000438	P49810	PSN2_HUMAN	presenilin 2 isoform 1	22	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			lung(2)	2		Prostate(94;0.0771)				CCCTAATGTCGGCTGAGAGCC	0.627													13	73					0	0	0	0	A	227069674	A	A	227069674	2	1	49	1	0	0	0	0	0	0	0	1	12713	1103	39	1		1	PSEN2	1	227069674	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	9276313	227069674	22180947	14	9763											
ACTN2	88	broad.mit.edu	37	chr1	236902717	236902717	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggattaccgccggaagcacaAgccacccaaggtgcaggaga	13	3	13	12	2	0	1	0	0	0	1	0	4	0	3	4	4	4	2	4	4	4	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:236902717A>G	uc001hyf.2	+	10	1196	c.992A>G	c.(991-993)AAG>AGG	p.K331R	ACTN2_uc001hyg.2_Missense_Mutation_p.K123R|ACTN2_uc009xgi.1_Missense_Mutation_p.K331R|ACTN2_uc010pxu.1_Intron|ACTN2_uc001hyh.2_Missense_Mutation_p.K19R	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	331	Spectrin 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGGAAGCACAAGCCACCCAAG	0.597													9	69					0	0	0	0	G	236902717	G	G	236902717	3	3	49	1	0	0	0	0	1	0	0	0	205	72	3	5	1030	5	ACTN2	1	236902717	Missense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	9833043	236902717	12347904	15	9764											
HNRNPU	3192	broad.mit.edu	37	chr1	245019776	245019776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcctttcattttgaggaccGcatgttctggtaggtctttc	5	17	10	9	1	3	1	1	1	2	0	4	2	3	2	2	3	1	3	2	3	1	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr1:245019776G>A	uc001iaz.1	-	10	2113	c.1895C>T	c.(1894-1896)GCG>GTG	p.A632V	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Missense_Mutation_p.A356V|HNRNPU_uc001iba.1_Missense_Mutation_p.A613V|HNRNPU_uc001ibb.1_Missense_Mutation_p.A320V	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	632					CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			TTTGAGGACCGCATGTTCTGG	0.368													4	210					0	0	0	0	A	245019776	A	A	245019776	3	1	49	1	0	0	0	0	1	0	0	0	7312	1087	38	1	602	1	HNRNPU	1	245019776	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	8117059	245019776	4230845	16	9765											
CENPO	79172	broad.mit.edu	37	chr2	25038610	25038610	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tactctgggaggaagtaccaGgcagaccggcttcaggtatc	10	8	13	10	1	2	1	1	0	1	1	3	3	2	3	2	5	2	4	2	5	4	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:25038610G>A	uc002rfo.1	+	5	768	c.579G>A	c.(577-579)CAG>CAA	p.Q193Q	CENPO_uc002rfn.2_Silent_p.Q193Q|CENPO_uc002rfp.1_Silent_p.Q187Q|CENPO_uc002rfq.1_Silent_p.Q193Q	NM_024322	NP_077298	Q9BU64	CENPO_HUMAN	centromere protein O	193					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GGAAGTACCAGGCAGACCGGC	0.468													25	121					0	0	0	0	A	25038610	A	A	25038610	2	1	49	1	0	0	0	0	0	0	0	1	3254	991	35	4		4	CENPO	2	25038610	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08		25038610	218160763	17	9766											
BIRC6	57448	broad.mit.edu	37	chr2	32730182	32730182	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcctacatctttcttccaGaggaggcttggtgtgacctt	6	14	11	10	0	2	2	0	1	2	1	4	3	4	3	3	4	1	1	3	4	1	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:32730182G>T	uc010ezu.2	+	50	9744	c.9610G>T	c.(9610-9612)GAG>TAG	p.E3204*		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3204					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTTTCTTCCAGAGGAGGCTTG	0.502													3	28					0.00024832	0.000272988	1	0	T	32730182	T	T	32730182	4	4	49	1	0	0	0	0	0	1	0	0	1441	943	33	2	9808	2	BIRC6	2	32730182	Nonsense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	7691572	32730182	210469191	18	9767											
ALMS1	7840	broad.mit.edu	37	chr2	73676156	73676156	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccatctacccgaagaggcTctgaaagtttcagctgtttc	10	11	9	11	1	3	2	1	1	2	1	4	3	3	2	2	1	3	4	2	1	3	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:73676156T>A	uc002sje.1	+	10	2616	c.2505T>A	c.(2503-2505)GCT>GCA	p.A835A	ALMS1_uc002sjf.1_Silent_p.A791A|ALMS1_uc002sjg.2_Silent_p.A221A|ALMS1_uc002sjh.1_Silent_p.A221A	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	833	7.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CCGAAGAGGCTCTGAAAGTTT	0.517													19	93					0	0	0	0	A	73676156	A	A	73676156	2	1	49	1	0	0	0	0	0	0	0	1	535	1538	54	5		5	ALMS1	2	73676156	Silent	SNP	T	TCGA-CN-4738-01A-02D-1512-08	40945974	73676156	169523217	19	9768											
ELMOD3	84173	broad.mit.edu	37	chr2	85598671	85598671	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatggaaaccactgggaggAcctgggctttcagggtaaga	11	8	14	8	0	2	1	2	0	0	1	2	4	2	4	2	5	1	2	2	5	2	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:85598671A>G	uc002spf.3	+	11	1258	c.593A>G	c.(592-594)GAC>GGC	p.D198G	ELMOD3_uc010fgg.2_Intron|ELMOD3_uc002spg.3_Missense_Mutation_p.D198G|ELMOD3_uc002sph.3_Missense_Mutation_p.D198G|ELMOD3_uc010ysn.1_Missense_Mutation_p.D198G|ELMOD3_uc010yso.1_RNA|ELMOD3_uc010ysp.1_Intron	NM_001135021	NP_001128493	Q96FG2	ELMD3_HUMAN	ELMO/CED-12 domain containing 3 isoform b	198	ELMO.				phagocytosis	cytoskeleton				ovary(2)	2						CACTGGGAGGACCTGGGCTTT	0.532													15	98					0	0	0	0	G	85598671	G	G	85598671	3	3	49	1	0	0	0	0	1	0	0	0	5094	275	10	5	619	5	ELMOD3	2	85598671	Missense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	11922515	85598671	157600702	20	9769											
ANAPC1	64682	broad.mit.edu	37	chr2	112638323	112638323	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattagggtggtgcttgcagTggtctcgaccaaaaggaaca	11	9	13	8	1	1	0	0	0	1	0	2	2	1	1	1	4	3	2	1	4	4	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:112638323T>C	uc002thi.2	-	2	327	c.80A>G	c.(79-81)CAC>CGC	p.H27R	ANAPC1_uc002thj.2_Missense_Mutation_p.H17R	NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	27					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						GTGCTTGCAGTGGTCTCGACC	0.468													9	57					0	0	0	0	C	112638323	C	C	112638323	3	2	49	1	0	0	0	0	1	0	0	0	598	1696	59	5	5942	5	ANAPC1	2	112638323	Missense_Mutation	SNP	T	TCGA-CN-4738-01A-02D-1512-08	27039652	112638323	130561050	21	9770											
PTPN4	5775	broad.mit.edu	37	chr2	120712819	120712819	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccactagatagtgtgcatCaggatgaccattccctgcgg	9	9	10	13	1	1	2	1	1	0	1	2	3	2	3	4	2	2	1	4	2	2	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:120712819C>G	uc002tmf.1	+	20	2671	c.1900C>G	c.(1900-1902)CAG>GAG	p.Q634E	PTPN4_uc010flj.1_Missense_Mutation_p.Q347E|PTPN4_uc010yyr.1_Missense_Mutation_p.Q267E	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	634						cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	TAGTGTGCATCAGGATGACCA	0.398													12	94					0	0	0	0	G	120712819	G	G	120712819	3	3	49	1	0	0	0	0	1	0	0	0	12855	827	29	2	1974	2	PTPN4	2	120712819	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	8074496	120712819	122486554	22	9771											
POTEE	445582	broad.mit.edu	37	chr2	131976431	131976431	+	Frame_Shift_Del	DEL	C	-	-																															gctgcctggtggggtaaagtCcccagaaaggatctcatcgt																										TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:131976431delC	uc002tsn.2	+	1	508	c.456delC	c.(454-456)GTCfs	p.V152fs	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_5'UTR|POTEE_uc002tsl.2_5'UTR	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	152							ATP binding				0						GGGGTAAAGTCCCCAGAAAGG	0.572													---	---	---								-	131976431	-	-	131976431	7	5	49	1	0	1	0	1	0	0	0	0	12319	842	30	0	458	0	POTEE	2	131976431	Frame_Shift_Del	DEL	C	TCGA-CN-4738-01A-02D-1512-08	11263612	131976431	111222942	23	9772											
LRP1B	53353	broad.mit.edu	37	chr2	141027890	141027890	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccatcacataactgacagcTagaggcaatctttccattag	13	10	7	11	0	2	2	1	1	1	1	3	2	3	2	2	1	2	2	2	1	4	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:141027890T>A	uc002tvj.1	-	86	14140	c.13168A>T	c.(13168-13170)AGC>TGC	p.S4390C		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4390	Extracellular (Potential).|EGF-like 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AACTGACAGCTAGAGGCAATC	0.403										TSP Lung(27;0.18)			7	111					0	0	0	0	A	141027890	A	A	141027890	3	1	49	1	0	0	0	0	1	0	0	0	9005	1522	53	5	655	5	LRP1B	2	141027890	Missense_Mutation	SNP	T	TCGA-CN-4738-01A-02D-1512-08	9051459	141027890	102171483	24	9773											
TTN	7273	broad.mit.edu	37	chr2	179596836	179596836	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtggtcactgccagcctcAttttgggcctcacacatata	9	11	8	13	0	3	0	3	0	0	0	3	0	3	0	3	2	2	0	3	2	2	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:179596836A>C	uc010zfg.1	-	54	13352	c.13128T>G	c.(13126-13128)AAT>AAG	p.N4376K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.N1037K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5303							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCCAGCCTCATTTTGGGCCT	0.468													19	225					0	0	0	0	C	179596836	C	C	179596836	3	2	49	1	0	0	0	0	1	0	0	0	16803	214	8	5	87893	5	TTN	2	179596836	Missense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	38568946	179596836	63602537	25	9774											
DNAH7	56171	broad.mit.edu	37	chr2	196825341	196825341	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggggcgcaaaccaggattaCagatcacttgaatgagagga	14	7	13	7	1	1	3	1	2	0	2	1	6	1	5	1	4	2	1	1	4	3	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:196825341C>T	uc002utj.3	-	18	2635	c.2534G>A	c.(2533-2535)TGT>TAT	p.C845Y		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	845	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ACCAGGATTACAGATCACTTG	0.443													21	172					0	0	0	0	T	196825341	T	T	196825341	3	4	49	1	0	0	0	0	1	0	0	0	4628	478	17	4	9732	4	DNAH7	2	196825341	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	17228505	196825341	46374032	26	9775											
PPIL3	53938	broad.mit.edu	37	chr2	201750420	201750420	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tatgtaaataatagtacttaCctcacatgttttgggtgtcc	11	16	7	7	0	1	0	1	0	0	0	2	0	2	0	2	1	2	3	2	1	7	8			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr2:201750420C>T	uc002uwh.2	-	3	319	c.78_splice	c.e3+1	p.E26_splice	PPIL3_uc002uwi.2_Splice_Site_p.E26_splice|PPIL3_uc002uwj.2_Splice_Site_p.E26_splice|PPIL3_uc002uwk.2_Splice_Site_p.E26_splice	NM_130906	NP_570981	Q9H2H8	PPIL3_HUMAN	peptidylprolyl isomerase-like 3 isoform PPIL3b						protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity|protein binding				0						ATAGTACTTACCTCACATGTT	0.318													4	100					0	0	0	0	T	201750420	T	T	201750420	5	4	49	1	0	0	0	0	0	0	1	0	12388	521	18	4	536	4	PPIL3	2	201750420	Splice_Site	SNP	C	TCGA-CN-4738-01A-02D-1512-08	4925079	201750420	41448953	27	9776											
PTPN23	25930	broad.mit.edu	37	chr3	47453167	47453167	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgctggtttctgaggctgaGatggagaaggtgagaagagg	11	9	18	3	0	1	5	0	3	1	4	1	8	1	5	0	5	1	3	0	5	2	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr3:47453167G>C	uc003crf.1	+	20	3975	c.3879G>C	c.(3877-3879)GAG>GAC	p.E1293D	PTPN23_uc011baw.1_Missense_Mutation_p.E1258D|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Missense_Mutation_p.E1163D|uc003cri.2_5'Flank	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	1293	Tyrosine-protein phosphatase.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGAGGCTGAGATGGAGAAGG	0.587													7	50					0	0	0	0	C	47453167	C	C	47453167	3	2	49	1	0	0	0	0	1	0	0	0	12853	933	33	2	3957	2	PTPN23	3	47453167	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		47453167	150569263	28	9777											
MST1	4485	broad.mit.edu	37	chr3	49724469	49724469	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgcggtctaccgcgccgcgGtattcctcgccattgcacca	5	9	11	16	6	1	0	0	0	1	0	3	0	2	0	5	2	3	2	5	2	2	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr3:49724469G>A	uc003cxg.2	-	6	711	c.639C>T	c.(637-639)TAC>TAT	p.Y213Y	MST1_uc011bcs.1_Silent_p.Y213Y|MST1_uc010hkx.2_Silent_p.Y134Y|MST1_uc011bct.1_Silent_p.Y213Y|MST1_uc011bcu.1_RNA|RNF123_uc003cxh.2_5'Flank	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	199	Kringle 2.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCGCGCCGCGGTATTCCTCGC	0.657													7	100					0	0	0	0	A	49724469	A	A	49724469	2	1	49	1	0	0	0	0	0	0	0	1	9943	1256	44	4		4	MST1	3	49724469	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	2271302	49724469	148297961	29	9778											
GNAI2	2771	broad.mit.edu	37	chr3	50290578	50290578	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgtgcaggcctgctttggCcgctcaagggaataccagct	7	9	14	11	1	1	0	1	0	0	0	1	1	1	1	3	4	4	4	3	4	3	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr3:50290578C>T	uc003cyq.1	+	4	547	c.426C>T	c.(424-426)GGC>GGT	p.G142G	GNAI2_uc003cyo.1_Silent_p.G126G|GNAI2_uc003cyp.1_Silent_p.G126G|GNAI2_uc010hlg.1_Silent_p.G61G|GNAI2_uc011bdn.1_Silent_p.G105G|GNAI2_uc003cyr.1_Silent_p.G61G	NM_002070	NP_002061	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein),	142					adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)		CCTGCTTTGGCCGCTCAAGGG	0.652													4	304					0	0	0	0	T	50290578	T	T	50290578	2	4	49	1	0	0	0	0	0	0	0	1	6542	726	26	4		4	GNAI2	3	50290578	Silent	SNP	C	TCGA-CN-4738-01A-02D-1512-08	566109	50290578	147731852	30	9779											
NISCH	11188	broad.mit.edu	37	chr3	52526308	52526308	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacgtgcaaggtcatgaccTcatgggcagtgtcaccctgg	8	9	13	11	1	3	2	3	2	0	0	3	2	3	2	2	3	1	2	2	3	1	0			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr3:52526308T>C	uc011beg.1	+	22	4397	c.4325T>C	c.(4324-4326)CTC>CCC	p.L1442P	NISCH_uc003ded.3_Missense_Mutation_p.L1442P|NISCH_uc003dee.3_Missense_Mutation_p.L931P|NISCH_uc003deg.1_Intron|NISCH_uc003deh.3_Missense_Mutation_p.L191P	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1442					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		GGTCATGACCTCATGGGCAGT	0.652													4	297					0	0	0	0	C	52526308	C	C	52526308	3	2	49	1	0	0	0	0	1	0	0	0	10486	1551	54	5	4407	5	NISCH	3	52526308	Missense_Mutation	SNP	T	TCGA-CN-4738-01A-02D-1512-08	2235730	52526308	145496122	31	9780											
C3orf30	152405	broad.mit.edu	37	chr3	118866242	118866242	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggatagccaagtagacctCaattccaagccttcagttga	13	9	9	10	0	2	2	2	1	0	1	3	4	3	3	4	1	2	2	4	1	5	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr3:118866242C>T	uc003ecb.1	+	1	1246	c.1206C>T	c.(1204-1206)CTC>CTT	p.L402L	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Silent_p.L402L	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	402										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		AAGTAGACCTCAATTCCAAGC	0.448													16	82					0	0	0	0	T	118866242	T	T	118866242	2	4	49	1	0	0	0	0	0	0	0	1	2230	813	29	2		2	C3orf30	3	118866242	Silent	SNP	C	TCGA-CN-4738-01A-02D-1512-08	66339934	118866242	79156188	32	9781											
SLITRK3	22865	broad.mit.edu	37	chr3	164906642	164906642	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gagaaaaacagaaccagcagGctgagaattaacacagaaag	21	3	10	7	0	0	4	0	1	0	4	0	6	0	4	1	1	4	2	1	1	6	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr3:164906642G>T	uc003fej.3	-	2	2421	c.1977C>A	c.(1975-1977)AGC>AGA	p.S659R	SLITRK3_uc003fek.2_Missense_Mutation_p.S659R	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	659	Helical; (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GAACCAGCAGGCTGAGAATTA	0.532										HNSCC(40;0.11)			6	46					0.00198382	0.00212461	1	0	T	164906642	T	T	164906642	3	4	49	1	0	0	0	0	1	0	0	0	14808	1194	42	4	960	4	SLITRK3	3	164906642	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	46040400	164906642	33115788	33	9782											
MFSD7	84179	broad.mit.edu	37	chr4	680361	680361	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccaggatccagatggccGccacgccaaatggggtggat	10	6	14	11	2	0	1	0	0	0	1	2	3	2	3	5	5	0	0	5	5	1	0			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr4:680361G>A	uc003gay.2	-	2	311	c.254C>T	c.(253-255)GCG>GTG	p.A85V	MFSD7_uc003gaw.2_5'Flank|MFSD7_uc003gax.2_Missense_Mutation_p.A85V|MFSD7_uc003gaz.2_Missense_Mutation_p.A63V|MFSD7_uc003gba.2_Missense_Mutation_p.A85V|MFSD7_uc003gbb.1_Missense_Mutation_p.A21V	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	85	Helical; (Potential).				transmembrane transport	integral to membrane					0						CCAGATGGCCGCCACGCCAAA	0.642													3	83					0	0	0	0	A	680361	A	A	680361	3	1	49	1	0	0	0	0	1	0	0	0	9590	1087	38	1	1461	1	MFSD7	4	680361	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		680361	190473915	34	9783											
WDR19	57728	broad.mit.edu	37	chr4	39217727	39217727	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttattataggagctaccaatCacagtttctgttgatgtgga	11	15	9	6	0	2	1	1	1	1	0	2	3	2	3	1	2	2	3	1	2	5	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr4:39217727C>G	uc003gtv.2	+	12	1300	c.1146C>G	c.(1144-1146)ATC>ATG	p.I382M	WDR19_uc003gtu.1_Missense_Mutation_p.I382M|WDR19_uc011byi.1_Missense_Mutation_p.I222M|WDR19_uc003gtw.1_Translation_Start_Site	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	382					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						AGCTACCAATCACAGTTTCTG	0.318													2	11					0	0	0	0	G	39217727	G	G	39217727	3	3	49	1	0	0	0	0	1	0	0	0	17347	816	29	2	1192	2	WDR19	4	39217727	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	38537366	39217727	151936549	35	9784											
RASGEF1B	153020	broad.mit.edu	37	chr4	82355102	82355102	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaattcactcacttgtttggCcagttcccaaaatttctgga	11	14	6	10	0	3	0	2	0	1	0	4	1	4	1	2	2	0	2	2	2	3	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr4:82355102C>T	uc003hmi.1	-	12	1360	c.1216G>A	c.(1216-1218)GCC>ACC	p.A406T	RASGEF1B_uc003hmj.1_Missense_Mutation_p.A405T|RASGEF1B_uc010ijq.1_Missense_Mutation_p.A364T	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	406	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						ACTTGTTTGGCCAGTTCCCAA	0.368													4	248					0	0	0	0	T	82355102	T	T	82355102	3	4	49	1	0	0	0	0	1	0	0	0	13135	739	26	4	217	4	RASGEF1B	4	82355102	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	43137375	82355102	108799174	36	9785											
CENPE	1062	broad.mit.edu	37	chr4	104062022	104062022	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttggtctctctccagtttGagtgtctcctctactcttct	4	18	7	12	0	6	1	0	1	6	0	9	1	6	1	2	1	1	2	2	1	1	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr4:104062022G>C	uc003hxb.1	-	36	5793	c.5703C>G	c.(5701-5703)CTC>CTG	p.L1901L	CENPE_uc003hxc.1_Silent_p.L1876L|CENPE_uc003hxd.1_5'Flank	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1901	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TCTCCAGTTTGAGTGTCTCCT	0.313													7	127					0	0	0	0	C	104062022	C	C	104062022	2	2	49	1	0	0	0	0	0	0	0	1	3245	1277	45	2		2	CENPE	4	104062022	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	21706920	104062022	87092254	37	9786											
C4orf21	55345	broad.mit.edu	37	chr4	113540216	113540216	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtgaggataaatacatggCccaccggcttttatttctca	10	13	8	10	1	1	1	1	1	1	0	2	2	1	2	2	3	1	1	2	3	4	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr4:113540216C>A	uc003iau.2	-	6	1193	c.982G>T	c.(982-984)GCC>TCC	p.A328S	C4orf21_uc003iaw.2_Missense_Mutation_p.A328S	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		AAATACATGGCCCACCGGCTT	0.398													28	136					1.77063e-15	2.19347e-15	1	0	A	113540216	A	A	113540216	3	1	49	1	0	0	0	0	1	0	0	0	2264	739	26	4	5424	4	C4orf21	4	113540216	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	9478194	113540216	77614060	38	9787											
ERCC8	1161	broad.mit.edu	37	chr5	60199489	60199489	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaataccctgtagaatgtgaGaacaggatccagacttcaag	16	8	9	8	0	1	3	1	1	0	3	2	5	2	4	2	1	2	1	2	1	6	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr5:60199489G>A	uc003jsm.3	-	6	606	c.536C>T	c.(535-537)TCT>TTT	p.S179F	ERCC8_uc003jsk.2_RNA|ERCC8_uc003jsl.3_Missense_Mutation_p.S121F|ERCC8_uc011cqp.1_Missense_Mutation_p.S26F|ERCC8_uc003jsn.3_Missense_Mutation_p.S179F	NM_000082	NP_000073	Q13216	ERCC8_HUMAN	excision repair cross-complementing rodent	179					positive regulation of DNA repair|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein polyubiquitination|response to oxidative stress|response to UV|response to UV|transcription-coupled nucleotide-excision repair	Cul4A-RING ubiquitin ligase complex|nuclear matrix|nucleoplasm|nucleotide-excision repair complex|soluble fraction	protein binding|protein complex binding				0		Lung NSC(810;1.51e-06)|Prostate(74;0.0322)|Ovarian(174;0.0481)|Breast(144;0.077)				TAGAATGTGAGAACAGGATCC	0.328								Direct_reversal_of_damage|NER					8	96					0	0	0	0	A	60199489	A	A	60199489	3	1	49	1	0	0	0	0	1	0	0	0	5243	942	33	2	682	2	ERCC8	5	60199489	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		60199489	120715771	39	9788											
GABRB2	2561	broad.mit.edu	37	chr5	160721372	160721372	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaagtcccatcacagcctCagatgtggccatttcatttt	9	13	6	13	0	3	1	3	0	0	1	5	1	5	1	4	1	1	0	4	1	1	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr5:160721372C>G	uc003lys.1	-	11	1473	c.1255G>C	c.(1255-1257)GAG>CAG	p.E419Q	GABRB2_uc011deh.1_Missense_Mutation_p.E220Q|GABRB2_uc003lyr.1_Missense_Mutation_p.E381Q|GABRB2_uc003lyt.1_Missense_Mutation_p.E381Q|GABRB2_uc010jiu.1_Missense_Mutation_p.E318Q	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	419	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATCACAGCCTCAGATGTGGCC	0.478													9	123					0	0	0	0	G	160721372	G	G	160721372	3	3	49	1	0	0	0	0	1	0	0	0	6201	835	29	2	287	2	GABRB2	5	160721372	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	100521883	160721372	20193888	40	9789											
SYNGAP1	8831	broad.mit.edu	37	chr6	33419553	33419553	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaggagaggcagcttccccCcttgggtccaacaaacccgc	9	5	11	16	1	0	1	0	0	0	1	2	2	2	1	5	3	3	3	5	3	2	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr6:33419553C>T	uc011dri.1	+	19	4097	c.3902C>T	c.(3901-3903)CCC>CTC	p.P1301L	ZBTB9_uc003oeq.2_5'Flank|SYNGAP1_uc010juy.2_Missense_Mutation_p.P1270L|SYNGAP1_uc010juz.2_3'UTR	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	1301					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CAGCTTCCCCCCTTGGGTCCA	0.652													4	24					0	0	0	0	T	33419553	T	T	33419553	3	4	49	1	0	0	0	0	1	0	0	0	15513	623	22	4	3976	4	SYNGAP1	6	33419553	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08		33419553	137695514	41	9790											
TRERF1	55809	broad.mit.edu	37	chr6	42235962	42235962	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgttgaggtggatcccactgGgggataggagggggcgatgg	7	8	21	5	1	0	1	0	1	0	0	1	5	1	4	1	8	0	1	1	8	1	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr6:42235962G>T	uc003osd.2	-	5	1930	c.1367C>A	c.(1366-1368)CCC>CAC	p.P456H	TRERF1_uc011duq.1_Missense_Mutation_p.P456H|TRERF1_uc003osb.2_Missense_Mutation_p.P295H|TRERF1_uc003osc.2_Missense_Mutation_p.P295H|TRERF1_uc003ose.2_Missense_Mutation_p.P456H	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	456	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GATCCCACTGGGGGATAGGAG	0.607													22	100					6.44725e-10	7.75539e-10	1	0	T	42235962	T	T	42235962	3	4	49	1	0	0	0	0	1	0	0	0	16542	1232	43	4	2291	4	TRERF1	6	42235962	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	8816409	42235962	128879105	42	9791											
EPHA7	2045	broad.mit.edu	37	chr6	93967234	93967234	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactctattactatcatgacTggtttccctaaaattaaaaa	16	14	3	8	0	2	1	1	1	1	0	3	1	3	1	1	1	2	1	1	1	9	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr6:93967234T>A	uc003poe.2	-	12	2359	c.2118A>T	c.(2116-2118)CCA>CCT	p.P706P	EPHA7_uc003pof.2_Silent_p.P701P|EPHA7_uc011eac.1_Silent_p.P702P	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	706	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CTATCATGACTGGTTTCCCTA	0.373													4	63					0	0	0	0	A	93967234	A	A	93967234	2	1	49	1	0	0	0	0	0	0	0	1	5196	1567	55	5		5	EPHA7	6	93967234	Silent	SNP	T	TCGA-CN-4738-01A-02D-1512-08	51731272	93967234	77147833	43	9792											
POU3F2	5454	broad.mit.edu	37	chr6	99283871	99283871	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctctggagagccatttcctCaaatgccccaagccctcggc	8	8	9	16	1	2	1	1	0	1	1	4	2	3	1	5	2	3	1	5	2	2	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr6:99283871C>G	uc003ppe.2	+	1	1292	c.1122C>G	c.(1120-1122)CTC>CTG	p.L374L		NM_005604	NP_005595	P20265	PO3F2_HUMAN	POU domain, class 3, transcription factor 2	374	Homeobox.				positive regulation of cell proliferation		identical protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0355)		GCCATTTCCTCAAATGCCCCA	0.587													7	106					0	0	0	0	G	99283871	G	G	99283871	2	3	49	1	0	0	0	0	0	0	0	1	12330	813	29	2		2	POU3F2	6	99283871	Silent	SNP	C	TCGA-CN-4738-01A-02D-1512-08	5316637	99283871	71831196	44	9793											
GRIK2	2898	broad.mit.edu	37	chr6	102074478	102074478	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctggtgcagtttttcaagtgGaaaaccgtcacggttgtgta	9	13	12	7	2	2	0	2	0	0	0	2	1	2	1	1	3	2	4	1	3	4	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr6:102074478G>A	uc003pqp.3	+	3	756	c.507G>A	c.(505-507)TGG>TGA	p.W169*	GRIK2_uc003pqn.2_Nonsense_Mutation_p.W169*|GRIK2_uc003pqo.3_Nonsense_Mutation_p.W169*|GRIK2_uc010kcw.2_Nonsense_Mutation_p.W169*	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	169	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TTTTCAAGTGGAAAACCGTCA	0.413													6	111					0	0	0	0	A	102074478	A	A	102074478	4	1	49	1	0	0	0	0	0	1	0	0	6813	1183	41	2	517	2	GRIK2	6	102074478	Nonsense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	2790607	102074478	69040589	45	9794											
CLVS2	134829	broad.mit.edu	37	chr6	123377032	123377032	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctctgagtttggaggaatgCtgcctccttatgacatgggg	7	12	13	9	0	1	2	0	2	1	0	2	4	2	4	3	4	2	2	3	4	2	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr6:123377032C>T	uc003pzi.1	+	5	1626	c.757C>T	c.(757-759)CTG>TTG	p.L253L		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	253	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TGGAGGAATGCTGCCTCCTTA	0.448													10	148					0	0	0	0	T	123377032	T	T	123377032	2	4	49	1	0	0	0	0	0	0	0	1	3587	796	28	4		4	CLVS2	6	123377032	Silent	SNP	C	TCGA-CN-4738-01A-02D-1512-08	21302554	123377032	47738035	46	9795											
SYNE1	23345	broad.mit.edu	37	chr6	152477074	152477074	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttccatggacatagcacaAatgtttctccaccgccggtc	9	11	7	14	2	1	0	0	0	1	0	4	1	2	1	4	2	1	2	4	2	2	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr6:152477074A>C	uc010kiw.2	-	132	24551	c.23949T>G	c.(23947-23949)ATT>ATG	p.I7983M	SYNE1_uc010kiv.2_Missense_Mutation_p.I2507M|SYNE1_uc003qos.3_Missense_Mutation_p.I2507M|SYNE1_uc003qot.3_Missense_Mutation_p.I7912M|SYNE1_uc003qou.3_Missense_Mutation_p.I7983M|SYNE1_uc003qop.3_Missense_Mutation_p.I145M|SYNE1_uc011eez.1_Missense_Mutation_p.I185M|SYNE1_uc003qoq.3_Missense_Mutation_p.I185M|SYNE1_uc003qor.3_Missense_Mutation_p.I883M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7983	Spectrin 28.|Cytoplasmic (Potential).|HAT 12.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACATAGCACAAATGTTTCTCC	0.498										HNSCC(10;0.0054)			10	104					0	0	0	0	C	152477074	C	C	152477074	3	2	49	1	0	0	0	0	1	0	0	0	15511	10	1	5	2577	5	SYNE1	6	152477074	Missense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	29100042	152477074	18637993	47	9796											
FOXK1	221937	broad.mit.edu	37	chr7	4720600	4720600	+	5'Flank	DEL	A	-	-																															caagagcgaaactccgtctcAaaaaaaaaaaaaaagaagga																										TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr7:4720600delA	uc003snc.1	+						FOXK1_uc003sna.1_Intron|FOXK1_uc003snb.1_5'Flank	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1						cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		actccgtctcaaaaaaaaaaa	0													---	---	---								-	4720600	-	-	4720600	6	5	49	0	1	1	0	1	0	0	0	0	6048	145	5	0		0	FOXK1	7	4720600	5'Flank	DEL	A	TCGA-CN-4738-01A-02D-1512-08		4720600	154418063	48	9797											
ICA1	3382	broad.mit.edu	37	chr7	8258017	8258017	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccataatagtgctcctctaTattccgtcctgcactgttcc	7	15	5	14	1	1	0	0	0	1	0	6	0	6	0	5	0	2	3	5	0	4	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr7:8258017T>C	uc003srm.2	-	6	564	c.497A>G	c.(496-498)TAT>TGT	p.Y166C	ICA1_uc010ktr.2_Missense_Mutation_p.Y166C|ICA1_uc003srl.2_Missense_Mutation_p.Y154C|ICA1_uc003srn.3_Missense_Mutation_p.Y92C|ICA1_uc003srp.3_Missense_Mutation_p.Y165C|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Missense_Mutation_p.Y166C|ICA1_uc003srr.2_Missense_Mutation_p.Y165C|ICA1_uc003sro.3_Missense_Mutation_p.Y166C|ICA1_uc011jxg.1_Missense_Mutation_p.Y166C|ICA1_uc003srs.1_Missense_Mutation_p.Y166C	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	166	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TGCTCCTCTATATTCCGTCCT	0.488													39	195					0	0	0	0	C	8258017	C	C	8258017	3	2	49	1	0	0	0	0	1	0	0	0	7516	1406	49	5	990	5	ICA1	7	8258017	Missense_Mutation	SNP	T	TCGA-CN-4738-01A-02D-1512-08	3537417	8258017	150880646	49	9798											
THSD7A	221981	broad.mit.edu	37	chr7	11441597	11441597	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttcaaataacagtcaccTgtaaaacacatatttgtaat	16	13	3	9	0	2	0	2	0	0	0	3	0	3	0	2	0	2	2	2	0	6	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr7:11441597T>A	uc003ssf.3	-	22	4490	c.4238_splice	c.e22-1	p.G1413_splice		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A							integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		AACAGTCACCTGTAAAACACA	0.443										HNSCC(18;0.044)			21	114					0	0	0	0	A	11441597	A	A	11441597	5	1	49	1	0	0	0	0	0	0	1	0	15945	1594	55	5	761	5	THSD7A	7	11441597	Splice_Site	SNP	T	TCGA-CN-4738-01A-02D-1512-08	3183580	11441597	147697066	50	9799											
TMEM196	256130	broad.mit.edu	37	chr7	19765251	19765251	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagagagagtgcagcccccGatcccaatgcacgcgagaga	13	3	13	12	3	0	3	0	0	0	3	1	8	1	3	3	0	3	2	3	0	2	0			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr7:19765251G>A	uc011jyg.1	-	3	430	c.345C>T	c.(343-345)ATC>ATT	p.I115I	TMEM196_uc003sur.2_RNA	NM_152774	NP_689987	Q5HYL7	TM196_HUMAN	transmembrane protein 196	121	Helical; (Potential).					integral to membrane					0						TGCAGCCCCCGATCCCAATGC	0.532													10	77					0	0	0	0	A	19765251	A	A	19765251	2	1	49	1	0	0	0	0	0	0	0	1	16184	1048	37	1		1	TMEM196	7	19765251	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	8323654	19765251	139373412	51	9800											
PHTF2	57157	broad.mit.edu	37	chr7	77531083	77531083	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttacttttttcagggtcTgcatttgcaaaggcaaagcc	10	15	8	8	0	2	0	1	0	1	0	2	0	2	0	1	2	4	3	1	2	3	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr7:77531083T>C	uc003ugs.3	+	6	417	c.291T>C	c.(289-291)TCT>TCC	p.S97S	PHTF2_uc003ugo.3_Silent_p.S59S|PHTF2_uc003ugp.2_Silent_p.S59S|PHTF2_uc003ugq.3_Silent_p.S59S|PHTF2_uc010ldv.2_Silent_p.S59S|PHTF2_uc003ugr.3_Silent_p.S63S|PHTF2_uc003ugt.3_Silent_p.S63S|PHTF2_uc003ugu.3_Silent_p.S59S	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						TTTCAGGGTCTGCATTTGCAA	0.323													2	7					0	0	0	0	C	77531083	C	C	77531083	2	2	49	1	0	0	0	0	0	0	0	1	11918	1567	55	5		5	PHTF2	7	77531083	Silent	SNP	T	TCGA-CN-4738-01A-02D-1512-08	57765832	77531083	81607580	52	9801											
CACNA2D1	781	broad.mit.edu	37	chr7	81746396	81746396	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtaggaatatggactgctgCgtgctgataagatatttgtc	11	13	12	5	1	0	2	0	1	0	1	1	4	0	4	0	2	3	3	0	2	5	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr7:81746396C>G	uc003uhr.1	-	6	746	c.490G>C	c.(490-492)GCA>CCA	p.A164P		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	164	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TGGACTGCTGCGTGCTGATAA	0.408													3	173					0	0	0	0	G	81746396	G	G	81746396	3	3	49	1	0	0	0	0	1	0	0	0	2560	768	27	3	2921	3	CACNA2D1	7	81746396	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	4215313	81746396	77392267	53	9802											
ZKSCAN5	23660	broad.mit.edu	37	chr7	99129118	99129118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggaaaagctacaaccaacGcgtgcacctaactcagcatc	14	6	8	13	2	1	0	1	0	0	0	2	1	1	1	2	1	7	3	2	1	6	2	rs141273536		TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr7:99129118G>A	uc003uqv.2	+	7	1890	c.1766G>A	c.(1765-1767)CGC>CAC	p.R589H	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.R589H|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.R589H|ZKSCAN5_uc003uqx.2_Missense_Mutation_p.R516H|ZKSCAN5_uc003uqy.2_Missense_Mutation_p.R325H	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	589	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TACAACCAACGCGTGCACCTA	0.488													7	57					0	0	0	0	A	99129118	A	A	99129118	3	1	49	1	0	0	0	0	1	0	0	0	17757	1087	38	1	1788	1	ZKSCAN5	7	99129118	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	17382722	99129118	60009545	54	9803											
CNTNAP2	26047	broad.mit.edu	37	chr7	146471413	146471413	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccccatgtggctttcagcAgctcctcctccatctctggt	4	13	7	17	0	2	0	1	0	1	0	7	0	6	0	5	2	2	3	5	2	0	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr7:146471413A>T	uc003weu.1	+	2	664	c.148A>T	c.(148-150)AGC>TGC	p.S50C		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	50	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GGCTTTCAGCAGCTCCTCCTC	0.428										HNSCC(39;0.1)			4	30					0	0	0	0	T	146471413	T	T	146471413	3	4	49	1	0	0	0	0	1	0	0	0	3662	188	7	5	154	5	CNTNAP2	7	146471413	Missense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	47342295	146471413	12667250	55	9804											
ANGPT2	285	broad.mit.edu	37	chr8	6378700	6378700	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcatgatatgtaaacttacaGtttgatgtggacatcatagt	13	14	9	5	0	1	2	1	2	0	0	1	3	1	3	0	1	2	3	0	1	5	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr8:6378700G>T	uc003wqj.3	-	4	1127	c.798C>A	c.(796-798)AAC>AAA	p.N266K	MCPH1_uc003wqi.2_Intron|ANGPT2_uc003wqk.3_Missense_Mutation_p.N266K|ANGPT2_uc010lri.2_Missense_Mutation_p.N214K|ANGPT2_uc003wql.3_Missense_Mutation_p.N266K	NM_001147	NP_001138	O15123	ANGP2_HUMAN	angiopoietin 2 isoform a precursor	266					angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			upper_aerodigestive_tract(1)	1		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		TAAACTTACAGTTTGATGTGG	0.353													17	90					5.3912e-06	6.21486e-06	1	0	T	6378700	T	T	6378700	3	4	49	1	0	0	0	0	1	0	0	0	611	1043	36	4	716	4	ANGPT2	8	6378700	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		6378700	139985322	56	9805											
HR	55806	broad.mit.edu	37	chr8	21986582	21986582	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggcccatggtgcagtccAtctcgaggcgggctgccggg	5	6	17	13	4	1	0	0	0	1	0	3	1	2	0	3	5	3	2	3	5	0	0			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr8:21986582A>C	uc003xas.2	-	2	767	c.102T>G	c.(100-102)GAT>GAG	p.D34E	HR_uc003xat.2_Missense_Mutation_p.D34E|HR_uc010lts.2_Missense_Mutation_p.D34E	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	34							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGTGCAGTCCATCTCGAGGCG	0.672													12	77					0	0	0	0	C	21986582	C	C	21986582	3	2	49	1	0	0	0	0	1	0	0	0	7386	214	8	5	3539	5	HR	8	21986582	Missense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	15607882	21986582	124377440	57	9806											
C8orf34	116328	broad.mit.edu	37	chr8	69633633	69633633	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagaagcactaatggaggaGggtgacgaatttgagaaagc	16	6	15	4	1	0	3	0	2	0	2	0	8	0	5	0	3	2	1	0	3	5	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr8:69633633G>T	uc010lyz.2	+	10	1156	c.1107G>T	c.(1105-1107)GAG>GAT	p.E369D	C8orf34_uc003xyb.2_Missense_Mutation_p.E344D	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	369					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			TAATGGAGGAGGGTGACGAAT	0.279													8	78					1.12685e-05	1.28121e-05	1	0	T	69633633	T	T	69633633	3	4	49	1	0	0	0	0	1	0	0	0	2434	991	35	4	1066	4	C8orf34	8	69633633	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	47647051	69633633	76730389	58	9807											
RIMS2	9699	broad.mit.edu	37	chr8	104898224	104898224	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttagatcctagctctgctgTaagaaaaacaaaacgggaaa	17	8	8	8	1	1	2	0	0	1	2	2	3	2	3	1	1	4	3	1	1	8	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr8:104898224T>C	uc003yls.2	+	2	972	c.731T>C	c.(730-732)GTA>GCA	p.V244A	RIMS2_uc003ylp.2_Missense_Mutation_p.V466A|RIMS2_uc003ylw.2_Missense_Mutation_p.V274A|RIMS2_uc003ylq.2_Missense_Mutation_p.V274A|RIMS2_uc003ylr.2_Missense_Mutation_p.V274A	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	497					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGCTCTGCTGTAAGAAAAACA	0.473										HNSCC(12;0.0054)			16	71					0	0	0	0	C	104898224	C	C	104898224	3	2	49	1	0	0	0	0	1	0	0	0	13433	1638	57	5	1537	5	RIMS2	8	104898224	Missense_Mutation	SNP	T	TCGA-CN-4738-01A-02D-1512-08	35264591	104898224	41465798	59	9808											
C8orf76	84933	broad.mit.edu	37	chr8	124253497	124253497	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgcagagcttggcgcagtaGgacgcgggcggtcctgaccg	6	6	17	12	6	0	2	0	1	0	1	2	3	1	3	2	4	1	4	2	4	1	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr8:124253497G>C	uc003yqc.1	-	1	121	c.90C>G	c.(88-90)TCC>TCG	p.S30S	C8orf76_uc003yqd.2_Intron	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	30							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGGCGCAGTAGGACGCGGGCG	0.527													2	11					0	0	0	0	C	124253497	C	C	124253497	2	2	49	1	0	0	0	0	0	0	0	1	2449	987	35	4		4	C8orf76	8	124253497	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	19355273	124253497	22110525	60	9809											
CDKN2A	1029	broad.mit.edu	37	chr9	21971017	21971017	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctcctcagccaggtccacgGgcagacggccccaggcatcg	7	4	13	17	3	1	1	1	0	0	1	4	1	3	1	5	4	1	3	5	4	0	0	rs121913386		TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr9:21971017G>A	uc003zpk.2	-	2	553	c.341C>T	c.(340-342)CCC>CTC	p.P114L	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.A169A	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	114	ANK 4.		P -> L (in non-small cell lung carcinoma).|P -> S (found in some patients with melanoma; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.P114L(21)|p.?(13)|p.P114H(3)|p.H83fs*2(2)|p.P114S(2)|p.A68fs*3(1)|p.P114P(1)|p.V115fs*11(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGGTCCACGGGCAGACGGCC	0.731	P114L(SKMEL30_SKIN)|P114L(WM983B_SKIN)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	40					0	0	0	0	A	21971017	A	A	21971017	3	1	49	1	0	0	0	0	1	0	0	0	3176	1232	43	4	137	4	CDKN2A	9	21971017	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		21971017	119242414	61	9810											
LINGO2	158038	broad.mit.edu	37	chr9	27950348	27950348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccttttaggcggagggaacGcaggttaaagagattgttga	11	10	15	5	2	0	2	0	1	0	1	0	5	0	4	1	4	1	3	1	4	4	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr9:27950348G>A	uc003zqu.1	-	2	516	c.322C>T	c.(322-324)CGT>TGT	p.R108C	LINGO2_uc010mjf.1_Missense_Mutation_p.R108C|LINGO2_uc003zqv.1_Missense_Mutation_p.R108C	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	108	LRR 3.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CGGAGGGAACGCAGGTTAAAG	0.438													28	163					0	0	0	0	A	27950348	A	A	27950348	3	1	49	1	0	0	0	0	1	0	0	0	8857	1087	38	1	1502	1	LINGO2	9	27950348	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	5979331	27950348	113263083	62	9811											
NCBP1	4686	broad.mit.edu	37	chr9	100412850	100412850	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagagaatcttcactgcatCattaagtcccactggaagga	14	9	9	9	0	3	1	2	0	1	1	4	5	4	3	1	2	1	1	1	2	4	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr9:100412850C>T	uc004axq.2	+	9	1422	c.963C>T	c.(961-963)ATC>ATT	p.I321I		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	321					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				TTCACTGCATCATTAAGTCCC	0.403													22	137					0	0	0	0	T	100412850	T	T	100412850	2	4	49	1	0	0	0	0	0	0	0	1	10265	816	29	2		2	NCBP1	9	100412850	Silent	SNP	C	TCGA-CN-4738-01A-02D-1512-08	72462502	100412850	40800581	63	9812											
GPR158	57512	broad.mit.edu	37	chr10	25887454	25887454	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	actcaaatcctgcggaggagCcaagaaagcctcagaaatct	15	6	9	11	1	3	2	2	0	1	2	4	4	4	4	3	2	3	0	3	2	4	0			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr10:25887454C>A	uc001isj.2	+	11	2959	c.2899C>A	c.(2899-2901)CCA>ACA	p.P967T	GPR158_uc001isk.2_Missense_Mutation_p.P342T	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	967	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TGCGGAGGAGCCAAGAAAGCC	0.458													7	152					8.12818e-05	9.11675e-05	1	0	A	25887454	A	A	25887454	3	1	49	1	0	0	0	0	1	0	0	0	6701	739	26	4	2941	4	GPR158	10	25887454	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08		25887454	109647293	64	9813											
POLL	27343	broad.mit.edu	37	chr10	103345697	103345697	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaagctcagccaggctgacTtcaccagctgagcacccggg	10	5	11	15	1	2	2	2	2	0	0	2	2	2	2	3	2	4	4	3	2	1	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr10:103345697T>C	uc001ktg.1	-	2	1098	c.332A>G	c.(331-333)AAG>AGG	p.K111R	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_5'Flank|POLL_uc001kth.1_Intron|POLL_uc001kti.1_Missense_Mutation_p.K111R|POLL_uc001ktj.1_Missense_Mutation_p.K111R|POLL_uc001ktf.2_Missense_Mutation_p.K111R|POLL_uc001ktk.1_Intron|POLL_uc010qqa.1_Intron|POLL_uc010qqb.1_Intron|POLL_uc001ktm.2_Missense_Mutation_p.K111R|POLL_uc001ktl.2_Missense_Mutation_p.K23R|POLL_uc010qqc.1_5'UTR|POLL_uc010qqd.1_Missense_Mutation_p.K23R|DPCD_uc001ktn.2_5'Flank	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	111	BRCT.				DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		CCAGGCTGACTTCACCAGCTG	0.577								DNA_polymerases_(catalytic_subunits)					12	45					0	0	0	0	C	103345697	C	C	103345697	3	2	49	1	0	0	0	0	1	0	0	0	12260	1609	56	5	1423	5	POLL	10	103345697	Missense_Mutation	SNP	T	TCGA-CN-4738-01A-02D-1512-08	77458243	103345697	32189050	65	9814											
PSD	5662	broad.mit.edu	37	chr10	104176509	104176509	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agatgaccacagagctctggGccccgggtgggggctgccca	7	5	16	13	1	1	3	0	1	1	2	1	3	1	3	4	4	2	2	4	4	0	0			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr10:104176509G>A	uc001kvg.1	-	2	814	c.287C>T	c.(286-288)GCC>GTC	p.A96V	PSD_uc001kvh.1_Intron|PSD_uc009xxd.1_Missense_Mutation_p.A96V|PSD_uc001kvi.1_Missense_Mutation_p.A96V|FBXL15_uc001kvj.1_5'Flank	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	96	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		AGAGCTCTGGGCCCCGGGTGG	0.657													6	85					0	0	0	0	A	104176509	A	A	104176509	3	1	49	1	0	0	0	0	1	0	0	0	12708	1203	42	4	2851	4	PSD	10	104176509	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	830812	104176509	31358238	66	9815											
CCDC147	159686	broad.mit.edu	37	chr10	106153149	106153149	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcaggtagatgagctgaaAgaagacatctctgccaaaga	16	7	10	8	0	2	6	1	2	1	4	3	6	2	6	1	1	2	2	1	1	4	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr10:106153149A>G	uc001kyh.2	+	11	1724	c.1590A>G	c.(1588-1590)AAA>AAG	p.K530K		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	530	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ATGAGCTGAAAGAAGACATCT	0.383													4	52					0	0	0	0	G	106153149	G	G	106153149	2	3	49	1	0	0	0	0	0	0	0	1	2793	69	3	5		5	CCDC147	10	106153149	Silent	SNP	A	TCGA-CN-4738-01A-02D-1512-08	1976640	106153149	29381598	67	9816											
OR52A5	390054	broad.mit.edu	37	chr11	5153039	5153039	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacaggtaaagatttgacaaGaggatatgaatatatggtgg	17	10	12	2	0	0	4	0	2	0	2	0	5	0	5	0	4	1	1	0	4	8	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:5153039G>A	uc010qyx.1	-	1	834	c.834C>T	c.(832-834)CTC>CTT	p.L278L		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		GATTTGACAAGAGGATATGAA	0.398													20	97					0	0	0	0	A	5153039	A	A	5153039	2	1	49	1	0	0	0	0	0	0	0	1	11164	929	33	2		2	OR52A5	11	5153039	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08		5153039	129853477	68	9817											
OR2D2	120776	broad.mit.edu	37	chr11	6913385	6913385	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcgatcataggacatcactGcaagaagggcgcactgggta	13	6	13	9	2	2	1	2	0	0	1	2	3	2	2	0	3	2	3	0	3	4	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:6913385G>A	uc010rau.1	-	1	347	c.347C>T	c.(346-348)GCA>GTA	p.A116V		NM_003700	NP_003691	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GGACATCACTGCAAGAAGGGC	0.488													14	89					0	0	0	0	A	6913385	A	A	6913385	3	1	49	1	0	0	0	0	1	0	0	0	11048	1319	46	4	582	4	OR2D2	11	6913385	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	1760346	6913385	128093131	69	9818											
ST5	6764	broad.mit.edu	37	chr11	8752204	8752204	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcagagctgcagggggaCggcaccacgctgggacagcc	8	6	15	12	2	1	1	1	0	0	1	1	3	1	3	2	4	3	4	2	4	0	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:8752204C>T	uc001mgt.2	-	3	819	c.633G>A	c.(631-633)CCG>CCA	p.P211P	ST5_uc009yfr.2_Intron|ST5_uc001mgu.2_Intron|ST5_uc001mgv.2_Silent_p.P211P|ST5_uc010rbq.1_Intron|ST5_uc001mgw.1_Silent_p.P211P	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	211					positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		TGCAGGGGGACGGCACCACGC	0.642													3	25					0	0	0	0	T	8752204	T	T	8752204	2	4	49	1	0	0	0	0	0	0	0	1	15286	523	19	1		1	ST5	11	8752204	Silent	SNP	C	TCGA-CN-4738-01A-02D-1512-08	1838819	8752204	126254312	70	9819											
MICAL2	9645	broad.mit.edu	37	chr11	12229646	12229646	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atccatgtgaatgtggagttCgtgaaggttctagagcctcc	9	12	12	8	1	1	3	0	2	1	1	4	4	3	4	3	2	1	2	3	2	3	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:12229646C>T	uc001mjz.2	+	5	837	c.549C>T	c.(547-549)TTC>TTT	p.F183F	MICAL2_uc010rch.1_Silent_p.F183F|MICAL2_uc001mjy.2_Silent_p.F183F|MICAL2_uc001mka.2_Silent_p.F183F|MICAL2_uc010rci.1_Silent_p.F183F|MICAL2_uc001mkb.2_Silent_p.F183F|MICAL2_uc001mkc.2_Silent_p.F183F|MICAL2_uc001mkd.2_Silent_p.F12F	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	183						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		ATGTGGAGTTCGTGAAGGTTC	0.423													21	174					0	0	0	0	T	12229646	T	T	12229646	2	4	49	1	0	0	0	0	0	0	0	1	9623	883	31	1		1	MICAL2	11	12229646	Silent	SNP	C	TCGA-CN-4738-01A-02D-1512-08	3477442	12229646	122776870	71	9820											
DGKZ	8525	broad.mit.edu	37	chr11	46397933	46397933	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagaaactgtcccccaagtGgtgcttcctggacggtgagt	8	9	12	12	1	0	2	0	1	0	1	2	3	2	3	4	3	2	1	4	3	2	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:46397933G>A	uc001ncn.1	+	24	2836	c.2711G>A	c.(2710-2712)TGG>TAG	p.W904*	DGKZ_uc001nch.1_Nonsense_Mutation_p.W732*|DGKZ_uc010rgq.1_Nonsense_Mutation_p.W659*|DGKZ_uc001ncj.1_Nonsense_Mutation_p.W682*|DGKZ_uc010rgr.1_Nonsense_Mutation_p.W681*|DGKZ_uc001nck.1_Nonsense_Mutation_p.W494*|DGKZ_uc001ncl.2_Nonsense_Mutation_p.W716*|DGKZ_uc001ncm.2_Nonsense_Mutation_p.W715*|DGKZ_uc009yky.1_Nonsense_Mutation_p.W716*|DGKZ_uc010rgs.1_Nonsense_Mutation_p.W693*	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	904					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TCCCCCAAGTGGTGCTTCCTG	0.622													39	197					0	0	0	0	A	46397933	A	A	46397933	4	1	49	1	0	0	0	0	0	1	0	0	4496	1357	47	4	3248	4	DGKZ	11	46397933	Nonsense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	34168287	46397933	88608583	72	9821											
OR8J1	219477	broad.mit.edu	37	chr11	56128372	56128372	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgattatagttctagtatCttatttcaatattgttttgt	9	23	5	4	0	3	1	1	1	2	0	3	1	3	1	0	0	0	3	0	0	7	12			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:56128372C>A	uc010rjh.1	+	1	650	c.650C>A	c.(649-651)TCT>TAT	p.S217Y		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GTTCTAGTATCTTATTTCAAT	0.328													15	118					4.7546e-09	5.6376e-09	1	0	A	56128372	A	A	56128372	3	1	49	1	0	0	0	0	1	0	0	0	11295	913	32	2	652	2	OR8J1	11	56128372	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	9730439	56128372	78878144	73	9822											
RPS6KA4	8986	broad.mit.edu	37	chr11	64129153	64129153	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggcatcttgctcttcgagCtgctgacgggggcctcgccc	3	10	14	14	3	2	1	0	1	2	0	4	2	2	1	2	3	3	4	2	3	0	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:64129153C>A	uc001oae.2	+	7	774	c.691C>A	c.(691-693)CTG>ATG	p.L231M	RPS6KA4_uc001oad.2_Missense_Mutation_p.L231M|RPS6KA4_uc010rnl.1_Missense_Mutation_p.L168M|RPS6KA4_uc001oaf.2_Missense_Mutation_p.L231M|RPS6KA4_uc009ypp.2_Missense_Mutation_p.L231M	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	231	Protein kinase 1.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						GCTCTTCGAGCTGCTGACGGG	0.687													5	90					0.00116845	0.00125949	1	0	A	64129153	A	A	64129153	3	1	49	1	0	0	0	0	1	0	0	0	13718	796	28	4	717	4	RPS6KA4	11	64129153	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	8000781	64129153	70877363	74	9823											
SPTBN2	6712	broad.mit.edu	37	chr11	66473195	66473195	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcagggcagaggcgctgacGgcccgcaccctctcggcctg	5	4	15	17	5	1	2	0	1	1	1	2	2	1	2	3	4	0	4	3	4	0	0			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:66473195G>A	uc001ojd.2	-	13	1839	c.1767C>T	c.(1765-1767)GCC>GCT	p.A589A		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	589	Spectrin 3.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						AGGCGCTGACGGCCCGCACCC	0.662													5	31					0	0	0	0	A	66473195	A	A	66473195	2	1	49	1	0	0	0	0	0	0	0	1	15186	1103	39	1		1	SPTBN2	11	66473195	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	2344042	66473195	68533321	75	9824											
CLPB	81570	broad.mit.edu	37	chr11	72040797	72040797	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcatcacttccccttctcggGcataatccaagggtgtgtgt	7	13	9	12	1	3	0	2	0	1	0	6	0	5	0	3	2	0	1	3	2	2	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:72040797G>A	uc001osj.2	-	7	967	c.917C>T	c.(916-918)GCC>GTC	p.A306V	CLPB_uc010rqx.1_Missense_Mutation_p.A261V|CLPB_uc010rqy.1_Missense_Mutation_p.A247V|CLPB_uc001osk.2_Missense_Mutation_p.A276V|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Missense_Mutation_p.A105V	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	306	ANK 4.				cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						CCCTTCTCGGGCATAATCCAA	0.512													3	87					0	0	0	0	A	72040797	A	A	72040797	3	1	49	1	0	0	0	0	1	0	0	0	3566	1203	42	4	1250	4	CLPB	11	72040797	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	5567602	72040797	62965719	76	9825											
POLD3	10714	broad.mit.edu	37	chr11	74329716	74329716	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caatgagctgaccaccaatgGtcatggcccacctgcatcca	11	7	8	15	0	1	2	1	2	0	0	2	2	2	2	5	2	2	2	5	2	2	0			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:74329716G>A	uc001ovf.1	+	6	602	c.527G>A	c.(526-528)GGT>GAT	p.G176D	POLD3_uc009yua.1_Missense_Mutation_p.G70D	NM_006591	NP_006582	Q15054	DPOD3_HUMAN	DNA-directed DNA polymerase delta 3	176					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			kidney(2)|ovary(1)	3	Breast(11;3.21e-06)					ACCACCAATGGTCATGGCCCA	0.483													19	136					0	0	0	0	A	74329716	A	A	74329716	3	1	49	1	0	0	0	0	1	0	0	0	12247	1261	44	4	549	4	POLD3	11	74329716	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	2288919	74329716	60676800	77	9826											
TMEM123	114908	broad.mit.edu	37	chr11	102272786	102272786	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagaagtcatatttgttgaGaccatccctggtgttgttgt	8	16	11	6	0	1	2	1	1	0	2	2	3	2	2	2	1	0	4	2	1	3	6	rs142725847	by1000genomes	TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:102272786G>C	uc001pha.2	-	3	730	c.309C>G	c.(307-309)GTC>GTG	p.V103V	TMEM123_uc009yxc.2_Silent_p.V84V	NM_052932	NP_443164	Q8N131	PORIM_HUMAN	transmembrane protein 123 precursor	103	Thr-rich.|Extracellular (Potential).				oncosis	external side of plasma membrane|integral to membrane	receptor activity			breast(2)	2	all_cancers(8;0.00027)|all_epithelial(12;0.0021)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0314)|Lung(13;0.109)|all cancers(10;0.12)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0149)		TATTTGTTGAGACCATCCCTG	0.438													28	282					0	0	0	0	C	102272786	C	C	102272786	2	2	49	1	0	0	0	0	0	0	0	1	16102	929	33	2		2	TMEM123	11	102272786	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	27943070	102272786	32733730	78	9827											
OPCML	4978	broad.mit.edu	37	chr11	132290129	132290129	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctaagagggtccctgatagCcagagacaagccagtgctct	11	7	12	11	0	1	3	0	1	1	2	2	4	2	3	3	1	3	2	3	1	3	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr11:132290129C>G	uc001qgs.2	-	7	1046	c.996G>C	c.(994-996)TGG>TGC	p.W332C	OPCML_uc001qgu.2_Missense_Mutation_p.W325C|OPCML_uc010sck.1_Missense_Mutation_p.W341C|OPCML_uc001qgt.2_Missense_Mutation_p.W331C|OPCML_uc010scl.1_Missense_Mutation_p.W291C	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	332					cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TCCCTGATAGCCAGAGACAAG	0.498													4	63					0	0	0	0	G	132290129	G	G	132290129	3	3	49	1	0	0	0	0	1	0	0	0	10928	740	26	4	45	4	OPCML	11	132290129	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	30017343	132290129	2716387	79	9828											
SCNN1A	6337	broad.mit.edu	37	chr12	6472662	6472662	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacctgggggttgttgtcccGcaagctggaggccacgctac	6	8	14	13	2	0	0	0	0	0	0	1	1	1	1	3	4	2	5	3	4	2	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr12:6472662G>A	uc001qnx.2	-	3	920	c.631C>T	c.(631-633)CGG>TGG	p.R211W	SCNN1A_uc001qnv.2_5'UTR|SCNN1A_uc001qnw.2_Missense_Mutation_p.R270W|SCNN1A_uc010sfb.1_Missense_Mutation_p.R234W	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	211	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	TTGTTGTCCCGCAAGCTGGAG	0.552													4	25					0	0	0	0	A	6472662	A	A	6472662	3	1	49	1	0	0	0	0	1	0	0	0	13992	1086	38	1	1422	1	SCNN1A	12	6472662	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		6472662	127379233	80	9829											
CD163	9332	broad.mit.edu	37	chr12	7640635	7640635	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccatgcttcacttcaacaCgtccagaacagggaatgtcc	12	8	7	14	1	2	1	2	0	0	1	4	2	4	2	3	1	3	1	3	1	3	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr12:7640635C>A	uc001qsz.3	-	7	1597	c.1469G>T	c.(1468-1470)CGT>CTT	p.R490L	CD163_uc001qta.3_Missense_Mutation_p.R490L|CD163_uc009zfw.2_Missense_Mutation_p.R490L	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	490	SRCR 5.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CACTTCAACACGTCCAGAACA	0.478													4	33					0.00024832	0.000272988	1	0	A	7640635	A	A	7640635	3	1	49	1	0	0	0	0	1	0	0	0	2982	536	19	3	2041	3	CD163	12	7640635	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	1167973	7640635	126211260	81	9830											
CLEC4D	338339	broad.mit.edu	37	chr12	8671707	8671708	+	Frame_Shift_Ins	INS	-	TT	TT																															gctgagagtgaaaggaactgINSttcagggatgggggcccatc																										TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr12:8671707_8671708insTT	uc001qun.2	+	4	528_529	c.335_336insTT	c.(334-336)TGTfs	p.C112fs		NM_080387	NP_525126	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	112	C-type lectin.|Extracellular (Potential).				innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)					GAAAGGAACTGTTCAGGGATGG	0.505													---	---	---								TT	8671708	TT	TT	8671707	7	5	49	1	0	1	1	0	0	0	0	0	3529	1377	48	0	349	0	CLEC4D	12	8671707	Frame_Shift_Ins	INS	-	TCGA-CN-4738-01A-02D-1512-08	1031072	8671707	125180188	82	9831											
SLC2A13	114134	broad.mit.edu	37	chr12	40441956	40441956	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatggtgactaatcggcctcTtaaattgggtggtgagacct	10	12	12	7	1	1	2	0	2	1	1	2	3	1	2	2	4	0	0	2	4	4	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr12:40441956T>C	uc010skm.1	-	2	664	c.613A>G	c.(613-615)AGA>GGA	p.R205G	SLC2A13_uc001rmf.2_Missense_Mutation_p.R205G	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	205	Cytoplasmic (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				AATCGGCCTCTTAAATTGGGT	0.423										HNSCC(50;0.14)			24	209					0	0	0	0	C	40441956	C	C	40441956	3	2	49	1	0	0	0	0	1	0	0	0	14606	1617	56	5	1369	5	SLC2A13	12	40441956	Missense_Mutation	SNP	T	TCGA-CN-4738-01A-02D-1512-08	31770249	40441956	93409939	83	9832											
LRRK2	120892	broad.mit.edu	37	chr12	40645303	40645303	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cactaaataatctccttatgTaccaaaacagtttacatgag	16	12	4	9	0	1	1	0	1	1	0	2	1	1	1	2	0	3	2	2	0	8	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr12:40645303T>G	uc001rmg.3	+	10	1259	c.1138T>G	c.(1138-1140)TAC>GAC	p.Y380D	LRRK2_uc001rmh.1_Missense_Mutation_p.Y2D	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	380					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCTCCTTATGTACCAAAACAG	0.318											OREG0003829	type=REGULATORY REGION|Gene=LRRK2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	4	27					0	0	0	0	G	40645303	G	G	40645303	3	3	49	1	0	0	0	0	1	0	0	0	9083	1638	57	5	1176	5	LRRK2	12	40645303	Missense_Mutation	SNP	T	TCGA-CN-4738-01A-02D-1512-08	203347	40645303	93206592	84	9833											
LRP1	4035	broad.mit.edu	37	chr12	57577638	57577638	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagacgtggcgtgaagacGtggtgaccaatggcattggc	10	7	15	9	3	0	4	0	2	0	2	0	4	0	4	2	4	0	1	2	4	2	1	rs144804370		TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr12:57577638G>T	uc001snd.2	+	36	6341	c.5875G>T	c.(5875-5877)GTG>TTG	p.V1959L		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1959	LDL-receptor class B 17.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCGTGAAGACGTGGTGACCAA	0.612													20	90					1.33834e-09	1.5983e-09	1	0	T	57577638	T	T	57577638	3	4	49	1	0	0	0	0	1	0	0	0	9001	1145	40	3	6017	3	LRP1	12	57577638	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	16932335	57577638	76274257	85	9834											
CCDC63	160762	broad.mit.edu	37	chr12	111311766	111311766	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggaaacccgtttgaatctcGtatgtaaagtgttctctgca	10	14	9	8	2	2	1	0	1	2	0	4	2	2	2	1	1	2	5	1	1	5	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr12:111311766G>A	uc001trv.1	+	5	684	c.489_splice	c.e5+1	p.L163_splice	CCDC63_uc009zvt.1_Splice_Site_p.L78_splice|CCDC63_uc010sye.1_Splice_Site_p.L123_splice|CCDC63_uc001trw.1_Splice_Site_p.L78_splice	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63											skin(6)|ovary(1)|pancreas(1)	8						TTTGAATCTCGTATGTAAAGT	0.443													31	145					0	0	0	0	A	111311766	A	A	111311766	5	1	49	1	0	0	0	0	0	0	1	0	2847	1159	40	1	504	1	CCDC63	12	111311766	Splice_Site	SNP	G	TCGA-CN-4738-01A-02D-1512-08	53734128	111311766	22540129	86	9835											
MAPKAPK5	8550	broad.mit.edu	37	chr12	112318261	112318261	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttgacaggtactggaggCgcaaagaaggcatcagaagg	13	6	14	8	1	2	3	1	1	1	2	2	4	2	4	0	5	1	3	0	5	4	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr12:112318261C>T	uc001tta.2	+	8	849	c.590C>T	c.(589-591)GCG>GTG	p.A197V	MAPKAPK5_uc001tsz.2_Missense_Mutation_p.A197V|MAPKAPK5_uc001ttb.2_Missense_Mutation_p.A130V	NM_139078	NP_620777	Q8IW41	MAPK5_HUMAN	MAP kinase-activated protein kinase 5 isoform 2	197	Protein kinase.				signal transduction	cytoplasm|nucleus	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)	3						GTACTGGAGGCGCAAAGAAGG	0.463													5	78					0	0	0	0	T	112318261	T	T	112318261	3	4	49	1	0	0	0	0	1	0	0	0	9344	768	27	1	620	1	MAPKAPK5	12	112318261	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	1006495	112318261	21533634	87	9836											
TMEM132B	114795	broad.mit.edu	37	chr12	126128668	126128668	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtgaatgggaaggaaatgaAgagcaaagtggacacgattg	16	7	15	3	1	0	3	0	2	0	1	0	7	0	6	0	3	1	1	0	3	5	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr12:126128668A>G	uc001uhe.1	+	6	1477	c.1469A>G	c.(1468-1470)AAG>AGG	p.K490R	TMEM132B_uc001uhf.1_Missense_Mutation_p.K2R	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	490	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AAGGAAATGAAGAGCAAAGTG	0.488													11	98					0	0	0	0	G	126128668	G	G	126128668	3	3	49	1	0	0	0	0	1	0	0	0	16112	72	3	5	1491	5	TMEM132B	12	126128668	Missense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	13810407	126128668	7723227	88	9837											
EFNB2	1948	broad.mit.edu	37	chr13	107147297	107147297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccagcttctagttctggaCgtcttgttggatctttattc	6	18	8	9	1	4	0	0	0	4	0	5	2	4	2	1	2	2	3	1	2	3	9			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr13:107147297C>T	uc001vqi.2	-	4	570	c.545G>A	c.(544-546)CGT>CAT	p.R182H		NM_004093	NP_004084	P52799	EFNB2_HUMAN	ephrin B2 precursor	182	Extracellular (Potential).				cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			ovary(1)	1	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					TAGTTCTGGACGTCTTGTTGG	0.393													12	276					0	0	0	0	T	107147297	T	T	107147297	3	4	49	1	0	0	0	0	1	0	0	0	4978	536	19	1	464	1	EFNB2	13	107147297	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08		107147297	8022581	89	9838											
PROZ	8858	broad.mit.edu	37	chr13	113824825	113824825	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaatgttcactgttacacagGaatattactgtaaaaacatg	17	12	6	6	0	1	0	1	0	0	0	1	1	1	1	0	1	3	3	0	1	8	5	rs150819115		TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr13:113824825G>T	uc001vta.1	+	7	679	c.672G>T	c.(670-672)AGG>AGT	p.R224S	PROZ_uc010agr.1_Missense_Mutation_p.R246S	NM_003891	NP_003882	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma	224	Peptidase S1.				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	TGTTACACAGGAATATTACTG	0.294													11	102					3.86212e-05	4.36131e-05	1	0	T	113824825	T	T	113824825	3	4	49	1	0	0	0	0	1	0	0	0	12624	1165	41	2	698	2	PROZ	13	113824825	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	6677528	113824825	1345053	90	9839											
SALL2	6297	broad.mit.edu	37	chr14	21992498	21992498	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cggccttctctggtggcacgGacataccataaggcaagcca	10	7	11	13	2	1	0	0	0	1	0	2	1	1	1	3	5	2	2	3	5	3	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr14:21992498G>T	uc001wbe.2	-	2	1646	c.1364C>A	c.(1363-1365)TCC>TAC	p.S455Y	SALL2_uc010tly.1_Missense_Mutation_p.S453Y|SALL2_uc010tlz.1_Missense_Mutation_p.S318Y|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Missense_Mutation_p.S320Y|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	455							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		TGGTGGCACGGACATACCATA	0.582													11	33					0.000673444	0.000730665	1	0	T	21992498	T	T	21992498	3	4	49	1	0	0	0	0	1	0	0	0	13876	1174	41	2	1663	2	SALL2	14	21992498	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		21992498	85357042	91	9840											
JUB	84962	broad.mit.edu	37	chr14	23447610	23447611	+	Frame_Shift_Ins	INS	-	ATTG	ATTG																															ctgtccagggcctggcaggcINSattgctctgcccatagatgc																										TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr14:23447610_23447611insATTG	uc001whz.2	-	2	1426_1427	c.1050_1051insCAAT	c.(1048-1053)AATGCCfs	p.N350fs	JUB_uc001why.2_5'Flank	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	350_351	LIM zinc-binding 1.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		GCCTGGCAGGCATTGCTCTGCC	0.545													---	---	---								ATTG	23447611	ATTG	ATTG	23447610	7	5	49	1	0	1	1	0	0	0	0	0	8007	710	25	0	593	0	JUB	14	23447610	Frame_Shift_Ins	INS	-	TCGA-CN-4738-01A-02D-1512-08	1455112	23447610	83901930	92	9841											
ADCY4	196883	broad.mit.edu	37	chr14	24793592	24793592	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatacgtgatggccagagctGggggcctgaagggagacaaa	12	6	16	7	1	0	4	0	2	0	2	0	5	0	4	2	4	2	1	2	4	4	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr14:24793592G>A	uc001wov.2	-	15	1835	c.1829C>T	c.(1828-1830)CCA>CTA	p.P610L	ADCY4_uc001wow.2_Missense_Mutation_p.P610L|ADCY4_uc010toh.1_Missense_Mutation_p.P296L|ADCY4_uc001wox.2_Missense_Mutation_p.P610L|ADCY4_uc001woy.2_Missense_Mutation_p.P610L	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	610					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		GGCCAGAGCTGGGGGCCTGAA	0.567													3	61					0	0	0	0	A	24793592	A	A	24793592	3	1	49	1	0	0	0	0	1	0	0	0	296	1348	47	4	1448	4	ADCY4	14	24793592	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	1345982	24793592	82555948	93	9842											
HECTD1	25831	broad.mit.edu	37	chr14	31642844	31642844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggagctcctgtggtgctgcGacctggtttgcatgctgatg	4	13	15	9	1	0	1	0	1	0	0	1	3	1	2	2	3	5	5	2	3	0	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr14:31642844G>A	uc001wrc.1	-	5	1261	c.772C>T	c.(772-774)CGC>TGC	p.R258C		NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	258					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GTGGTGCTGCGACCTGGTTTG	0.493													6	81					0	0	0	0	A	31642844	A	A	31642844	3	1	49	1	0	0	0	0	1	0	0	0	7078	1058	37	1	7216	1	HECTD1	14	31642844	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	6849252	31642844	75706696	94	9843											
SLC8A3	6547	broad.mit.edu	37	chr14	70527612	70527612	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgaagaaattctcttgcCtttcgtattcctcctcatct	9	16	4	12	1	3	2	1	1	2	1	7	2	5	2	3	0	1	1	3	0	4	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr14:70527612C>T	uc001xly.2	-	3	2583	c.1829G>A	c.(1828-1830)AGG>AAG	p.R610K	SLC8A3_uc001xlu.2_Intron|SLC8A3_uc001xlv.2_5'UTR|SLC8A3_uc001xlw.2_Missense_Mutation_p.R610K|SLC8A3_uc001xlx.2_Intron|SLC8A3_uc001xlz.2_Missense_Mutation_p.R610K|SLC8A3_uc010ara.2_Intron|SLC8A3_uc001xma.2_Intron	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	610	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ATTCTCTTGCCTTTCGTATTC	0.378													27	98					0	0	0	0	T	70527612	T	T	70527612	3	4	49	1	0	0	0	0	1	0	0	0	14772	681	24	4	978	4	SLC8A3	14	70527612	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	38884768	70527612	36821928	95	9844											
NDNL2	56160	broad.mit.edu	37	chr15	29561302	29561302	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggtagacccctaagcgcCgcagaaagtcccaggcttca	10	6	12	13	2	1	2	1	0	0	2	2	2	2	2	4	3	1	3	4	3	3	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr15:29561302C>A	uc001zco.2	-	1	716	c.608G>T	c.(607-609)CGG>CTG	p.R203L	FAM189A1_uc010azk.1_Intron	NM_138704	NP_619649	Q96MG7	MAGG1_HUMAN	necdin-like 2	203	MAGE.				regulation of growth	cytoplasm|nucleus					0		all_lung(180;4.69e-11)|Breast(32;0.0013)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00736)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CCCTAAGCGCCGCAGAAAGTC	0.512													15	77					3.27435e-08	3.82776e-08	1	0	A	29561302	A	A	29561302	3	1	49	1	0	0	0	0	1	0	0	0	10302	652	23	3	310	3	NDNL2	15	29561302	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08		29561302	72970090	96	9845											
DMXL2	23312	broad.mit.edu	37	chr15	51757808	51757808	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagaaattcttgacattgtGaagtgctagtttaaccattg	14	14	8	5	0	1	3	0	2	1	1	1	3	1	3	1	0	2	2	1	0	5	7			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr15:51757808G>A	uc002abf.2	-	31	7783	c.7558C>T	c.(7558-7560)CAC>TAC	p.H2520Y	DMXL2_uc002abd.2_Missense_Mutation_p.H591Y|DMXL2_uc010ufy.1_Missense_Mutation_p.H2521Y|DMXL2_uc010bfa.2_Missense_Mutation_p.H1884Y	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2520						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TTGACATTGTGAAGTGCTAGT	0.333													23	173					0	0	0	0	A	51757808	A	A	51757808	3	1	49	1	0	0	0	0	1	0	0	0	4617	1290	45	2	1604	2	DMXL2	15	51757808	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	22196506	51757808	50773584	97	9846											
NTRK3	4916	broad.mit.edu	37	chr15	88483890	88483890	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttgtccttggtcgggctGaggttgtagcactcggccag	5	12	14	10	2	1	1	0	1	1	0	4	1	2	1	2	4	1	4	2	4	1	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr15:88483890G>T	uc002bme.1	-	14	1842	c.1680C>A	c.(1678-1680)CTC>CTA	p.L560L	NTRK3_uc002bmh.2_Silent_p.L552L|NTRK3_uc002bmf.1_Silent_p.L560L|NTRK3_uc010upl.1_Silent_p.L462L|NTRK3_uc010bnh.1_Silent_p.L552L	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	560	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGGTCGGGCTGAGGTTGTAGC	0.582			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			39	120					1.08169e-08	1.27348e-08	1	0	T	88483890	T	T	88483890	2	4	49	1	0	0	0	0	0	0	0	1	10762	1277	45	2		2	NTRK3	15	88483890	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	36726082	88483890	14047502	98	9847											
MYH11	4629	broad.mit.edu	37	chr16	15812199	15812199	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggctttgcggacccggtcGctcatggcctccatgttgcc	3	11	13	14	3	1	0	1	0	0	0	3	1	2	1	4	4	2	3	4	4	0	2	rs139620532		TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr16:15812199G>T	uc002ddy.2	-	37	5375	c.5268C>A	c.(5266-5268)AGC>AGA	p.S1756R	MYH11_uc002ddv.2_Missense_Mutation_p.S1763R|MYH11_uc002ddw.2_Missense_Mutation_p.S1756R|MYH11_uc002ddx.2_Missense_Mutation_p.S1763R|MYH11_uc010bvg.2_Missense_Mutation_p.S1588R|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.S462R	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1756	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GGACCCGGTCGCTCATGGCCT	0.567			T	CBFB	AML								16	88					1.37285e-15	1.71349e-15	1	0	T	15812199	T	T	15812199	3	4	49	1	0	0	0	0	1	0	0	0	10084	1078	38	3	705	3	MYH11	16	15812199	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		15812199	74542554	99	9848											
OTOA	146183	broad.mit.edu	37	chr16	21693074	21693074	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaagctcccacgtgtggacGgatgacctgtcccacagagt	9	8	12	12	2	0	3	0	2	0	1	2	5	2	5	3	2	1	1	3	2	1	0			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr16:21693074G>T	uc002djh.2	+	5	196	c.195G>T	c.(193-195)ACG>ACT	p.T65T	uc002diq.3_Intron|OTOA_uc010vbj.1_5'Flank	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	65					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		ACGTGTGGACGGATGACCTGT	0.512													10	51					0.00829132	0.00882281	1	0	T	21693074	T	T	21693074	2	4	49	1	0	0	0	0	0	0	0	1	11356	1103	39	3		3	OTOA	16	21693074	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	5880875	21693074	68661679	100	9849											
TP53	7157	broad.mit.edu	37	chr17	7576855	7576855	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcccaagacttagtacctGaagggtgaaatattctccat	12	11	9	9	0	1	3	0	2	1	1	3	3	2	3	3	2	1	1	3	2	6	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr17:7576855G>A	uc002gim.2	-	9	1185	c.991C>T	c.(991-993)CAG>TAG	p.Q331*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.Q331*|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Nonsense_Mutation_p.Q199*|TP53_uc010cng.1_Nonsense_Mutation_p.Q199*|TP53_uc002gii.1_Nonsense_Mutation_p.Q199*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q331*|TP53_uc010cni.1_Nonsense_Mutation_p.Q331*|TP53_uc002gij.2_Nonsense_Mutation_p.Q331*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	331	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(14)|p.0?(7)|p.Q331P(3)|p.Q331fs*6(1)|p.?(1)|p.Q331Q(1)|p.Q331R(1)|p.Q331H(1)|p.Q331fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTAGTACCTGAAGGGTGAAA	0.448		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	108					0	0	0	0	A	7576855	A	A	7576855	4	1	49	1	0	0	0	0	0	1	0	0	16448	1299	45	2	291	2	TP53	17	7576855	Nonsense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		7576855	73618355	101	9850											
TP53	7157	broad.mit.edu	37	chr17	7578395	7578395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctatctgagcagcgctcatGgtgggggcagcgcctcacaa	8	7	14	12	2	3	1	2	1	1	0	3	1	3	1	1	3	3	4	1	3	2	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr17:7578395G>A	uc002gim.2	-	5	729	c.535C>T	c.(535-537)CAT>TAT	p.H179Y	TP53_uc002gig.1_Missense_Mutation_p.H179Y|TP53_uc002gih.2_Missense_Mutation_p.H179Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47Y|TP53_uc010cng.1_Missense_Mutation_p.H47Y|TP53_uc002gii.1_Missense_Mutation_p.H47Y|TP53_uc010cnh.1_Missense_Mutation_p.H179Y|TP53_uc010cni.1_Missense_Mutation_p.H179Y|TP53_uc002gij.2_Missense_Mutation_p.H179Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86Y|TP53_uc002gio.2_Missense_Mutation_p.H47Y|TP53_uc010vug.1_Missense_Mutation_p.H140Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCTCATGGTGGGGGCAG	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	73					0	0	0	0	A	7578395	A	A	7578395	3	1	49	1	0	0	0	0	1	0	0	0	16448	1348	47	4	763	4	TP53	17	7578395	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	1540	7578395	73616815	102	9851											
FLOT2	2319	broad.mit.edu	37	chr17	27209178	27209178	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaggctgacttttgcagctcGaaggctcgcttagagtcagc	9	10	12	10	2	1	2	1	1	0	1	3	3	1	2	0	2	3	5	0	2	3	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr17:27209178G>A	uc002hdc.2	-	7	780	c.657C>T	c.(655-657)TTC>TTT	p.F219F		NM_004475	NP_004466	Q14254	FLOT2_HUMAN	flotillin 2	219					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction					0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			TTTGCAGCTCGAAGGCTCGCT	0.542													15	109					0	0	0	0	A	27209178	A	A	27209178	2	1	49	1	0	0	0	0	0	0	0	1	5969	1049	37	1		1	FLOT2	17	27209178	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	19630783	27209178	53986032	103	9852											
IKZF3	22806	broad.mit.edu	37	chr17	37933964	37933964	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgcttgctaatctgtccaGtacgagagctctttcacttc	8	15	7	11	1	3	1	1	0	2	1	5	2	4	1	1	0	4	4	1	0	2	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr17:37933964G>A	uc002hsu.2	-	7	828	c.766C>T	c.(766-768)CTG>TTG	p.L256L	IKZF3_uc002htd.2_Silent_p.L222L|IKZF3_uc010cwd.2_Silent_p.L113L|IKZF3_uc002hsv.2_Silent_p.L183L|IKZF3_uc010cwe.2_Intron|IKZF3_uc010cwf.2_Silent_p.L74L|IKZF3_uc010cwg.2_Intron|IKZF3_uc002hsw.2_Silent_p.L217L|IKZF3_uc002hsx.2_Silent_p.L200L|IKZF3_uc002hsy.2_Intron|IKZF3_uc002hsz.2_Silent_p.L161L|IKZF3_uc002hta.2_Intron|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Silent_p.L169L|IKZF3_uc002htc.2_Silent_p.L9L|IKZF3_uc010wel.1_Silent_p.L9L	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	256					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			AATCTGTCCAGTACGAGAGCT	0.398													17	108					0	0	0	0	A	37933964	A	A	37933964	2	1	49	1	0	0	0	0	0	0	0	1	7655	1020	36	4		4	IKZF3	17	37933964	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	10724786	37933964	43261246	104	9853											
PRCD	768206	broad.mit.edu	37	chr17	74538650	74538650	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttagggagaaagaacctctGaagtaagccctcacctctgc	12	9	9	11	0	3	3	1	1	2	2	3	4	3	3	3	1	3	1	3	1	5	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr17:74538650G>A	uc002jrx.2	+	3	262	c.159G>A	c.(157-159)CTG>CTA	p.L53L	CYGB_uc002jrv.1_Intron|PRCD_uc002jrw.1_5'UTR|PRCD_uc002jry.1_5'UTR|PRCD_uc002jrz.1_5'Flank	NM_001077620	NP_001071088	Q00LT1	PRCD_HUMAN	progressive rod-cone degeneration	53					response to stimulus|visual perception	cytoplasm|integral to membrane					0						AAGAACCTCTGAAGTAAGCCC	0.607													7	64					0	0	0	0	A	74538650	A	A	74538650	2	1	49	1	0	0	0	0	0	0	0	1	12510	1277	45	2		2	PRCD	17	74538650	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	36604686	74538650	6656560	105	9854											
MYOM1	8736	broad.mit.edu	37	chr18	3135616	3135616	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcctgcagaattagaacagCggacacggaaacagtaggat	15	6	11	9	2	0	2	0	0	0	2	1	5	1	5	1	3	4	2	1	3	5	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr18:3135616C>A	uc002klp.2	-	15	2472	c.2138G>T	c.(2137-2139)CGC>CTC	p.R713L	MYOM1_uc002klq.2_Missense_Mutation_p.R713L	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	713	Fibronectin type-III 2.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						ATTAGAACAGCGGACACGGAA	0.512													8	46					1.06961e-07	1.24165e-07	1	0	A	3135616	A	A	3135616	3	1	49	1	0	0	0	0	1	0	0	0	10144	768	27	3	3015	3	MYOM1	18	3135616	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08		3135616	74941632	106	9855											
RBBP8	5932	broad.mit.edu	37	chr18	20555121	20555121	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacattgtttttaagtgaatGaaaggaatactctacaggaa	16	12	8	5	0	1	2	0	2	1	0	1	4	1	4	0	2	2	1	0	2	7	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr18:20555121G>C	uc002ktw.2	+	6	698	c.367G>C	c.(367-369)GAA>CAA	p.E123Q	RBBP8_uc002kty.2_Missense_Mutation_p.E123Q|RBBP8_uc002ktz.2_Missense_Mutation_p.E123Q|RBBP8_uc002kua.2_Missense_Mutation_p.E123Q|RBBP8_uc002ktx.1_Missense_Mutation_p.E123Q	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	123	Potential.				cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			TTAAGTGAATGAAAGGAATAC	0.264								Direct_reversal_of_damage|Homologous_recombination					5	83					0	0	0	0	C	20555121	C	C	20555121	3	2	49	1	0	0	0	0	1	0	0	0	13170	1291	45	2	385	2	RBBP8	18	20555121	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	17419505	20555121	57522127	107	9856											
CHAF1A	10036	broad.mit.edu	37	chr19	4428796	4428796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcctccagcagcagagcggcGagttctccttcttgaaagac	9	9	10	13	2	2	3	0	1	2	2	5	4	4	3	3	1	3	3	3	1	1	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr19:4428796G>A	uc002mal.2	+	8	1613	c.1513G>A	c.(1513-1515)GAG>AAG	p.E505K		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	505					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGAGCGGCGAGTTCTCCTT	0.582								Chromatin_Structure					10	68					0	0	0	0	A	4428796	A	A	4428796	3	1	49	1	0	0	0	0	1	0	0	0	3326	1059	37	1	1543	1	CHAF1A	19	4428796	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		4428796	54700187	108	9857											
ZNF99	7652	broad.mit.edu	37	chr19	22940600	22940600	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacattcttcacatttgtagGgtttctttccagtatgaatt	9	18	6	8	0	3	1	1	1	2	0	4	1	4	1	1	1	0	3	1	1	3	8			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr19:22940600G>C	uc010xrh.1	-	5	1838	c.1838C>G	c.(1837-1839)CCC>CGC	p.P613R		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACATTTGTAGGGTTTCTTTCC	0.373													8	71					0	0	0	0	C	22940600	C	C	22940600	3	2	49	1	0	0	0	0	1	0	0	0	18271	1232	43	4	1286	4	ZNF99	19	22940600	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	18511804	22940600	36188383	109	9858											
ZNF540	163255	broad.mit.edu	37	chr19	38103919	38103919	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atacgggtgtaaaaccatacAaatgtaaagaatgtgggaag	18	8	11	4	1	0	1	0	0	0	1	0	2	0	2	1	2	3	2	1	2	9	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr19:38103919A>G	uc002ogq.2	+	5	2070	c.1738A>G	c.(1738-1740)AAA>GAA	p.K580E	ZNF540_uc002ogu.2_Missense_Mutation_p.K580E|ZNF540_uc010efq.2_Missense_Mutation_p.K548E	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	580	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAAACCATACAAATGTAAAGA	0.398													9	127					0	0	0	0	G	38103919	G	G	38103919	3	3	49	1	0	0	0	0	1	0	0	0	18042	131	5	5	1752	5	ZNF540	19	38103919	Missense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	15163319	38103919	21025064	110	9859											
VN1R2	317701	broad.mit.edu	37	chr19	53762257	53762257	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaaagccccgacatacattgGtctctccaatatcctgtgct	11	11	6	13	1	1	0	0	0	1	0	4	1	3	0	4	1	3	1	4	1	5	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr19:53762257G>A	uc002qbi.2	+	1	713	c.629G>A	c.(628-630)GGT>GAT	p.G210D		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	210	Helical; Name=4; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		ACATACATTGGTCTCTCCAAT	0.458													6	57					0	0	0	0	A	53762257	A	A	53762257	3	1	49	1	0	0	0	0	1	0	0	0	17247	1261	44	4	631	4	VN1R2	19	53762257	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	15658338	53762257	5366726	111	9860											
ZNF582	147948	broad.mit.edu	37	chr19	56895798	56895798	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgccagtatgaacagtctGatgttgaatcaactgagaac	13	10	9	9	0	2	4	1	4	1	1	2	5	2	4	2	0	4	2	2	0	5	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr19:56895798G>C	uc002qmz.1	-	5	1147	c.988C>G	c.(988-990)CAG>GAG	p.Q330E	ZNF582_uc002qmy.2_Missense_Mutation_p.Q361E	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	330	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		TGAACAGTCTGATGTTGAATC	0.383													3	160					0	0	0	0	C	56895798	C	C	56895798	3	2	49	1	0	0	0	0	1	0	0	0	18081	1299	45	2	569	2	ZNF582	19	56895798	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	3133541	56895798	2233185	112	9861											
NRSN2	80023	broad.mit.edu	37	chr20	333907	333907	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggtgtggcggctctgacCactggctatgcagtgccccc	4	9	14	14	1	1	1	0	1	1	0	1	1	1	1	3	4	2	3	3	4	1	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr20:333907C>T	uc002wdi.3	+	4	781	c.243C>T	c.(241-243)ACC>ACT	p.T81T	NRSN2_uc002wdj.2_RNA|NRSN2_uc002wdl.2_Intron	NM_024958	NP_079234	Q9GZP1	NRSN2_HUMAN	neurensin 2	81	Helical; (Potential).					integral to membrane|plasma membrane|transport vesicle					0		all_cancers(10;0.0834)				CGGCTCTGACCACTGGCTATG	0.642													20	125					0	0	0	0	T	333907	T	T	333907	2	4	49	1	0	0	0	0	0	0	0	1	10717	581	21	4		4	NRSN2	20	333907	Silent	SNP	C	TCGA-CN-4738-01A-02D-1512-08		333907	62691613	113	9862											
CST1	1469	broad.mit.edu	37	chr20	23731351	23731351	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccttgttatactcgctgatGgcgaagtgaagggcacgctg	8	10	14	9	3	0	2	0	2	0	0	1	3	0	2	1	2	1	4	1	2	4	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr20:23731351G>A	uc002wtp.2	-	1	224	c.153C>T	c.(151-153)GCC>GCT	p.A51A		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	51						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					ACTCGCTGATGGCGAAGTGAA	0.577													22	95					0	0	0	0	A	23731351	A	A	23731351	2	1	49	1	0	0	0	0	0	0	0	1	3987	1335	47	4		4	CST1	20	23731351	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	23397444	23731351	39294169	114	9863											
C20orf114	92747	broad.mit.edu	37	chr20	31887714	31887714	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccttgagcagtgcccatttCcctcagcattgaccgtctgg	6	12	9	14	1	2	2	1	2	1	0	4	2	4	2	4	1	3	2	4	1	0	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr20:31887714C>A	uc002wyw.1	+	8	832	c.671C>A	c.(670-672)TCC>TAC	p.S224Y	C20orf114_uc002wyx.1_5'Flank	NM_033197	NP_149974	Q8TDL5	LPLC1_HUMAN	LPLUNC1 protein precursor	224						extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4						GTGCCCATTTCCCTCAGCATT	0.557											OREG0025869	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	114					6.44725e-10	7.75539e-10	1	0	A	31887714	A	A	31887714	3	1	49	1	0	0	0	0	1	0	0	0	2092	855	30	2	697	2	C20orf114	20	31887714	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	8156363	31887714	31137806	115	9864											
NPEPL1	79716	broad.mit.edu	37	chr20	57268962	57268962	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacctgcctgccgcccggagCgcatcgctgcattgtggtga	5	8	14	14	4	0	1	0	1	0	0	1	3	0	2	4	2	4	3	4	2	0	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr20:57268962C>A	uc010zzs.1	+	2	415	c.320C>A	c.(319-321)GCG>GAG	p.A107E	NPEPL1_uc010zzr.1_Missense_Mutation_p.A59E|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Missense_Mutation_p.A79E|NPEPL1_uc002xzp.2_5'UTR	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	107					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			CCGCCCGGAGCGCATCGCTGC	0.706													4	12					0.00909568	0.00961709	1	0	A	57268962	A	A	57268962	3	1	49	1	0	0	0	0	1	0	0	0	10628	768	27	3	172	3	NPEPL1	20	57268962	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	25381248	57268962	5756558	116	9865											
LAMA5	3911	broad.mit.edu	37	chr20	60906173	60906173	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaactcctcaatgggcaccaGagtgaccccgtgctgcaggc	9	6	12	14	1	1	2	1	1	0	1	2	3	2	2	4	2	3	3	4	2	2	0			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr20:60906173G>A	uc002ycq.2	-	29	3632	c.3565C>T	c.(3565-3567)CTG>TTG	p.L1189L		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1189	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATGGGCACCAGAGTGACCCCG	0.532													3	16					0	0	0	0	A	60906173	A	A	60906173	2	1	49	1	0	0	0	0	0	0	0	1	8649	933	33	2		2	LAMA5	20	60906173	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	3637211	60906173	2119347	117	9866											
SLC5A3	6526	broad.mit.edu	37	chr21	35468451	35468451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcatagttgtcccaggaatGatttccaggatactgtttac	11	14	8	8	0	1	1	1	1	0	0	3	3	3	3	2	2	2	2	2	2	4	6			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr21:35468451G>A	uc002yto.2	+	2	1466	c.954G>A	c.(952-954)ATG>ATA	p.M318I	MRPS6_uc002ytp.2_Intron	NM_006933	NP_008864	P53794	SC5A3_HUMAN	solute carrier family 5 (inositol transporters),	318	Helical; (Potential).					integral to plasma membrane	myo-inositol:sodium symporter activity			ovary(2)	2						TCCCAGGAATGATTTCCAGGA	0.463													14	192					0	0	0	0	A	35468451	A	A	35468451	3	1	49	1	0	0	0	0	1	0	0	0	14730	1290	45	2	956	2	SLC5A3	21	35468451	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		35468451	12661444	118	9867											
HIRA	7290	broad.mit.edu	37	chr22	19340889	19340889	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggagcctcaccttcgtttacGaggtaccgtgcgtagacgag	8	9	13	11	5	1	1	1	0	0	1	2	4	1	2	3	2	4	3	3	2	3	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr22:19340889G>A	uc002zpf.1	-	23	3058	c.2838C>T	c.(2836-2838)CTC>CTT	p.L946L	HIRA_uc011agx.1_Silent_p.L812L|HIRA_uc010grn.1_Silent_p.L739L|HIRA_uc010gro.1_Silent_p.L902L|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	946	Interaction with histone H4.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					CTTCGTTTACGAGGTACCGTG	0.597													6	21					0	0	0	0	A	19340889	A	A	19340889	2	1	49	1	0	0	0	0	0	0	0	1	7159	1045	37	1		1	HIRA	22	19340889	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08		19340889	31963677	119	9868											
MCM5	4174	broad.mit.edu	37	chr22	35812693	35812693	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gctgctgccaactcagtgttCggccgctgggatgagacgaa	8	8	14	11	3	1	1	1	1	0	1	2	4	1	2	2	2	3	4	2	2	2	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr22:35812693C>G	uc003anu.3	+	12	1570	c.1476C>G	c.(1474-1476)TTC>TTG	p.F492L	MCM5_uc010gwr.2_Missense_Mutation_p.F301L|MCM5_uc003anv.3_Missense_Mutation_p.F449L|MCM5_uc010gws.1_RNA|MCM5_uc003anw.1_Missense_Mutation_p.F276L	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	492	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						ACTCAGTGTTCGGCCGCTGGG	0.577													3	96					0	0	0	0	G	35812693	G	G	35812693	3	3	49	1	0	0	0	0	1	0	0	0	9443	883	31	3	1518	3	MCM5	22	35812693	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	16471804	35812693	15491873	120	9869											
APOL6	80830	broad.mit.edu	37	chr22	36054943	36054943	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggaagcctgctgctctccaCcgctggtcaaggtttggcaa	8	9	12	12	1	2	0	1	0	1	0	3	1	2	1	3	4	3	5	3	4	3	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chr22:36054943C>T	uc003aoe.2	+	3	626	c.332C>T	c.(331-333)ACC>ATC	p.T111I	APOL6_uc003aod.2_RNA	NM_030641	NP_085144	Q9BWW8	APOL6_HUMAN	apolipoprotein L6	111					lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity				0						CTGCTCTCCACCGCTGGTCAA	0.572													6	69					0	0	0	0	T	36054943	T	T	36054943	3	4	49	1	0	0	0	0	1	0	0	0	810	507	18	4	338	4	APOL6	22	36054943	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	242250	36054943	15249623	121	9870											
TLR7	51284	broad.mit.edu	37	chrX	12905767	12905767	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacaaccaactgaccactGtccctgagagattatccaac	13	7	6	15	0	0	3	0	2	0	1	2	4	2	3	5	0	3	0	5	0	4	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chrX:12905767G>A	uc004cvc.2	+	3	2279	c.2140G>A	c.(2140-2142)GTC>ATC	p.V714I		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	714	LRR 24.|Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ACTGACCACTGTCCCTGAGAG	0.418													15	76					0	0	0	0	A	12905767	A	A	12905767	3	1	49	1	0	0	0	0	1	0	0	0	16022	1377	48	4	2146	4	TLR7	23	12905767	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08		12905767	142364793	122	9871											
CA5B	11238	broad.mit.edu	37	chrX	15792452	15792452	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtgcattggaacgcagtcAgatttgaaaactttgaggat	13	12	11	5	1	1	3	1	2	0	1	1	5	1	5	0	2	3	2	0	2	4	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chrX:15792452A>T	uc004cxe.2	+	5	604	c.487A>T	c.(487-489)AGA>TGA	p.R163*		NM_007220	NP_009151	Q9Y2D0	CAH5B_HUMAN	carbonic anhydrase VB, mitochondrial precursor	163					one-carbon metabolic process	mitochondrion	carbonate dehydratase activity|zinc ion binding				0	Hepatocellular(33;0.183)					GAACGCAGTCAGATTTGAAAA	0.403													6	45					0	0	0	0	T	15792452	T	T	15792452	4	4	49	1	0	0	0	0	0	1	0	0	2532	180	7	5	501	5	CA5B	23	15792452	Nonsense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	2886685	15792452	139478108	123	9872											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29972705	29972705	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccagtggaatcaagagaCtggggaagaagaacgttttg	14	8	14	5	1	1	4	1	1	0	3	1	7	1	6	1	3	1	1	1	3	5	2			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chrX:29972705C>G	uc004dby.2	+	10	1776	c.1268C>G	c.(1267-1269)ACT>AGT	p.T423S		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	423	Cytoplasmic (Potential).|TIR.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						AATCAAGAGACTGGGGAAGAA	0.363													9	45					0	0	0	0	G	29972705	G	G	29972705	3	3	49	1	0	0	0	0	1	0	0	0	7700	565	20	4	1302	4	IL1RAPL1	23	29972705	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	14180253	29972705	125297855	124	9873											
TRO	7216	broad.mit.edu	37	chrX	54951479	54951479	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttcccagaaatcattgaacGagcaagctacactctggaga	14	9	8	10	1	2	3	1	1	1	2	3	5	3	3	1	1	4	2	1	1	4	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chrX:54951479G>A	uc004dtq.2	+	6	1570	c.1463G>A	c.(1462-1464)CGA>CAA	p.R488Q	TRO_uc004dts.2_Missense_Mutation_p.R488Q|TRO_uc004dtr.2_Missense_Mutation_p.R488Q|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_RNA|TRO_uc004dtv.2_Missense_Mutation_p.R91Q|TRO_uc011mok.1_Missense_Mutation_p.R19Q|TRO_uc004dtw.2_Missense_Mutation_p.R91Q|TRO_uc004dtx.2_5'UTR	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	488	MAGE.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						ATCATTGAACGAGCAAGCTAC	0.473													4	34					0	0	0	0	A	54951479	A	A	54951479	3	1	49	1	0	0	0	0	1	0	0	0	16641	1058	37	1	1481	1	TRO	23	54951479	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	24978774	54951479	100319081	125	9874											
PCDH11X	27328	broad.mit.edu	37	chrX	91133549	91133549	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtgttgtaattgtcaatctGttcgtgaatgagtcggtgac	9	15	12	5	2	2	3	1	3	1	0	4	3	2	3	0	1	0	3	0	1	3	4			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chrX:91133549G>T	uc004efk.1	+	2	3155	c.2310G>T	c.(2308-2310)CTG>CTT	p.L770L	PCDH11X_uc004efl.1_Silent_p.L770L|PCDH11X_uc004efo.1_Silent_p.L770L|PCDH11X_uc010nmv.1_Silent_p.L770L|PCDH11X_uc004efm.1_Silent_p.L770L|PCDH11X_uc004efn.1_Silent_p.L770L|PCDH11X_uc004efh.1_Silent_p.L770L|PCDH11X_uc004efj.1_Silent_p.L770L	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	770	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TTGTCAATCTGTTCGTGAATG	0.423													13	91					4.36969e-10	5.33359e-10	1	0	T	91133549	T	T	91133549	2	4	49	1	0	0	0	0	0	0	0	1	11562	1364	48	4		4	PCDH11X	23	91133549	Silent	SNP	G	TCGA-CN-4738-01A-02D-1512-08	36182070	91133549	64137011	126	9875											
ARL13A	392509	broad.mit.edu	37	chrX	100243214	100243214	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacaggaatgtcaaaggagaAaagacagcatctagaacaat	21	5	9	6	0	2	3	1	0	1	3	2	5	2	4	0	2	3	1	0	2	8	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chrX:100243214A>G	uc004ego.2	+	7	802	c.686A>G	c.(685-687)AAA>AGA	p.K229R	ARL13A_uc011mrf.1_Missense_Mutation_p.K229R|ARL13A_uc010nng.2_Missense_Mutation_p.K229R	NM_001012990	NP_001013008	Q5H913	AR13A_HUMAN	ADP-ribosylation factor-like 13 isoform a	229							GTP binding			ovary(1)	1						TCAAAGGAGAAAAGACAGCAT	0.418													2	15					0	0	0	0	G	100243214	G	G	100243214	3	3	49	1	0	0	0	0	1	0	0	0	928	14	1	5	708	5	ARL13A	23	100243214	Missense_Mutation	SNP	A	TCGA-CN-4738-01A-02D-1512-08	9109665	100243214	55027346	127	9876											
ZMAT1	84460	broad.mit.edu	37	chrX	101139287	101139287	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaactggctttccactggtGaaatatggtatggtcgttgg	8	14	13	6	1	0	1	0	1	0	0	2	1	1	1	1	5	1	4	1	5	4	5			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chrX:101139287G>A	uc004eim.2	-	2	4097	c.599C>T	c.(598-600)TCA>TTA	p.S200L	ZMAT1_uc011mrl.1_Missense_Mutation_p.S371L|ZMAT1_uc004ein.2_Missense_Mutation_p.S200L|ZMAT1_uc011mrm.1_Missense_Mutation_p.S200L	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	200						nucleus	zinc ion binding			ovary(1)	1						TTCCACTGGTGAAATATGGTA	0.423													43	162					0	0	0	0	A	101139287	A	A	101139287	3	1	49	1	0	0	0	0	1	0	0	0	17758	1294	45	2	808	2	ZMAT1	23	101139287	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	896073	101139287	54131273	128	9877											
DCAF12L1	139170	broad.mit.edu	37	chrX	125686312	125686312	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caccttgttgaccgtgcccaGctccagttggcgctccgtca	5	10	10	16	3	1	1	1	1	0	0	3	1	3	1	5	1	2	4	5	1	0	3			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chrX:125686312G>T	uc004eul.2	-	1	531	c.280C>A	c.(280-282)CTG>ATG	p.L94M		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	94										skin(3)|ovary(1)	4						ACCGTGCCCAGCTCCAGTTGG	0.662													13	34					9.31168e-06	1.06603e-05	1	0	T	125686312	T	T	125686312	3	4	49	1	0	0	0	0	1	0	0	0	4281	962	34	4	1115	4	DCAF12L1	23	125686312	Missense_Mutation	SNP	G	TCGA-CN-4738-01A-02D-1512-08	24547025	125686312	29584248	129	9878											
CXorf1	9142	broad.mit.edu	37	chrX	144909491	144909491	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaatgcagtctcccagggCcctgccaagaacatatctgt	11	8	9	13	0	2	2	0	0	2	2	3	2	2	2	3	1	3	1	3	1	4	1			TCGA-CN-4738-01A-02D-1512-08	TCGA-CN-4738-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d3b16fd-f98b-45ef-a423-861975f098b6	f6ebf6a1-d79d-4fbe-ac24-04a009ae08b4	g.chrX:144909491C>A	uc004fch.2	+	1	564	c.296C>A	c.(295-297)GCC>GAC	p.A99D		NM_004709	NP_004700	O96002	CX001_HUMAN	hypothetical protein LOC9142	99											0	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCCAGGGCCCTGCCAAGA	0.398													12	25					9.05144e-12	1.11299e-11	1	0	A	144909491	A	A	144909491	3	1	49	1	0	0	0	0	1	0	0	0	4117	739	26	4	298	4	CXorf1	23	144909491	Missense_Mutation	SNP	C	TCGA-CN-4738-01A-02D-1512-08	19223179	144909491	10361069	130	9879											
ALDH4A1	8659	broad.mit.edu	37	chr1	19209865	19209865	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcatacttggcattgaaccGgaagaagtcgatgagttccg	11	9	12	9	4	0	3	0	2	0	1	2	5	1	4	2	2	2	3	2	2	4	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:19209865G>A	uc001bbb.2	-	6	787	c.511C>T	c.(511-513)CGG>TGG	p.R171W	ALDH4A1_uc010ocu.1_Missense_Mutation_p.R111W|ALDH4A1_uc001bbc.2_Missense_Mutation_p.R171W	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	171					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	GCATTGAACCGGAAGAAGTCG	0.632													3	64					0	0	0	0	A	19209865	A	A	19209865	3	1	50	1	0	0	0	0	1	0	0	0	501	1115	39	1	1220	1	ALDH4A1	1	19209865	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08		19209865	230040756	1	9880											
IQCC	55721	broad.mit.edu	37	chr1	32671827	32671827	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtatgaggcgattgtacgaGaggtcgagggcgacctgggc	9	7	18	7	4	0	2	0	1	0	1	1	6	0	2	1	4	1	2	1	4	2	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:32671827G>A	uc001bum.2	+	2	162	c.115G>A	c.(115-117)GAG>AAG	p.E39K	IQCC_uc009vua.2_Missense_Mutation_p.E119K|IQCC_uc010ogz.1_5'UTR|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	39										ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GATTGTACGAGAGGTCGAGGG	0.612													56	140					0	0	0	0	A	32671827	A	A	32671827	3	1	50	1	0	0	0	0	1	0	0	0	7843	943	33	2	361	2	IQCC	1	32671827	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	13461962	32671827	216578794	2	9881											
BMP8B	656	broad.mit.edu	37	chr1	40229411	40229411	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgaggtcctggaagctgacGtagagctcgtgccgacggca	8	6	15	12	5	0	2	0	1	0	1	2	5	1	3	3	3	3	4	3	3	2	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:40229411G>T	uc001cdz.1	-	5	1297	c.921C>A	c.(919-921)TAC>TAA	p.Y307*	BMP8B_uc001cea.1_Nonsense_Mutation_p.Y332*|PPIE_uc001cdv.2_Silent_p.T296T|PPIE_uc001cdw.2_3'UTR	NM_001720	NP_001711	P34820	BMP8B_HUMAN	bone morphogenetic protein 8B preproprotein	307					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity				0	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GGAAGCTGACGTAGAGCTCGT	0.562													106	61					4.60726e-43	6.18343e-43	1	0	T	40229411	T	T	40229411	4	4	50	1	0	0	0	0	0	1	0	0	1470	1140	40	3	299	3	BMP8B	1	40229411	Nonsense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	7557584	40229411	209021210	3	9882											
ST3GAL3	6487	broad.mit.edu	37	chr1	44201936	44201937	+	Nonsense_Mutation	DNP	GG	TT	TT																															atcgtaaatcatgtgaagatGggactcttggtatttgtgcg																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:44201936_44201937GG>TT	uc001ckc.2	+	2	180_181	c.3_4GG>TT	c.(1-6)ATGGGA>ATTTGA	p.1_2MG>I*	ST3GAL3_uc009vwu.1_RNA|ST3GAL3_uc010okj.1_RNA|ST3GAL3_uc001cjz.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001cka.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001ckb.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001ckd.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001cke.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001ckf.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001ckg.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001ckh.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001cki.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc009vwv.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001ckj.2_RNA|ST3GAL3_uc009vww.2_RNA|ST3GAL3_uc001ckk.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc009vwy.2_5'UTR|ST3GAL3_uc009vwx.2_RNA|ST3GAL3_uc001ckm.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001ckl.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc009vwz.2_5'UTR|ST3GAL3_uc001ckn.2_RNA|ST3GAL3_uc001ckp.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001cko.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc009vxa.2_5'UTR|ST3GAL3_uc001ckq.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc001ckr.2_Nonsense_Mutation_p.1_2MG>I*|ST3GAL3_uc009vxb.2_Nonsense_Mutation_p.1_2MG>I*	NM_006279	NP_006270	Q11203	SIAT6_HUMAN	sialyltransferase 6 isoform j	1_2	Cytoplasmic (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			ovary(3)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				ATGTGAAGATGGGACTCTTGGT	0.381													71	298					0	0	0	0	TT	44201937	TT	TT	44201936	4	4	50	1	0	0	0	0	0	1	0	0	15282	1348	47	4	5	4	ST3GAL3	1	44201936	Nonsense_Mutation	DNP	GG	TCGA-CN-4739-01A-02D-1512-08	3972525	44201936	205048685	4	9883											
DMBX1	127343	broad.mit.edu	37	chr1	46976315	46976315	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtgcaccaacctgcctgagGcccgggtgcaggtagggccc	6	6	15	14	1	0	1	0	1	0	0	0	1	0	1	5	4	4	3	5	4	2	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:46976315G>A	uc001cpx.2	+	2	352	c.337G>A	c.(337-339)GCC>ACC	p.A113T	DMBX1_uc001cpw.2_Missense_Mutation_p.A108T	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	113	Homeobox.|Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CCTGCCTGAGGCCCGGGTGCA	0.602													38	49					0	0	0	0	A	46976315	A	A	46976315	3	1	50	1	0	0	0	0	1	0	0	0	4600	1203	42	4	343	4	DMBX1	1	46976315	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	2774379	46976315	202274306	5	9884											
KTI12	112970	broad.mit.edu	37	chr1	52499375	52499375	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccagcgccacgcgcaacTcttcagcacgccggctcttg	7	6	10	18	5	3	0	1	0	2	0	3	0	3	0	3	1	4	3	3	1	1	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:52499375T>C	uc001ctj.1	-	1	98	c.59A>G	c.(58-60)GAG>GGG	p.E20G	TXNDC12_uc001cti.2_Intron	NM_138417	NP_612426	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated	20							ATP binding			central_nervous_system(2)	2						CACGCGCAACTCTTCAGCACG	0.682													5	23					0	0	0	0	C	52499375	C	C	52499375	3	2	50	1	0	0	0	0	1	0	0	0	8624	1551	54	5	1009	5	KTI12	1	52499375	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	5523060	52499375	196751246	6	9885											
JAK1	3716	broad.mit.edu	37	chr1	65335021	65335021	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgggcagttctggcaacTgcatcttcttcatcatggca	7	13	9	12	0	5	0	2	0	3	0	5	0	5	0	1	3	2	5	1	3	1	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:65335021T>A	uc001dbu.1	-	6	869	c.620A>T	c.(619-621)CAG>CTG	p.Q207L	JAK1_uc009wam.1_Missense_Mutation_p.Q195L	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	207	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TTCTGGCAACTGCATCTTCTT	0.488			Mis		ALL								56	142					0	0	0	0	A	65335021	A	A	65335021	3	1	50	1	0	0	0	0	1	0	0	0	7976	1580	55	5	2924	5	JAK1	1	65335021	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	12835646	65335021	183915600	7	9886											
LPHN2	23266	broad.mit.edu	37	chr1	82436043	82436043	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttctacactttttctttttgGcagcttttgcttggatgtgc	4	21	8	8	0	2	0	0	0	2	0	2	1	2	1	0	2	4	3	0	2	1	9			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:82436043G>A	uc001dit.3	+	15	2909	c.2728G>A	c.(2728-2730)GCA>ACA	p.A910T	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.A910T|LPHN2_uc001div.2_Missense_Mutation_p.A910T|LPHN2_uc009wcd.2_Missense_Mutation_p.A910T|LPHN2_uc001diw.2_Missense_Mutation_p.A494T|LPHN2_uc009wce.1_5'UTR	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	923	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TTTCTTTTTGGCAGCTTTTGC	0.358													75	254					0	0	0	0	A	82436043	A	A	82436043	3	1	50	1	0	0	0	0	1	0	0	0	8966	1203	42	4	2778	4	LPHN2	1	82436043	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	17101022	82436043	166814578	8	9887											
OLFM3	118427	broad.mit.edu	37	chr1	102270397	102270397	+	Silent	SNP	C	A	A																															ttgtatgtccttgattcagcCccactgacaaagtctgcaat																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:102270397C>A	uc001duf.2	-	6	905	c.834G>T	c.(832-834)GGG>GGT	p.G278G	OLFM3_uc001dug.2_Silent_p.G258G|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Silent_p.G183G|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	278	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TTGATTCAGCCCCACTGACAA	0.368													26	110					1.26454e-06	1.40709e-06	1	0	A	102270397	A	A	102270397	2	1	50	1	0	0	0	0	0	0	0	1	10908	610	22	4		4	OLFM3	1	102270397	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	19834354	102270397	146980224	9	9888	23	2									
OLFM3	118427	broad.mit.edu	37	chr1	102270399	102270399	+	Missense_Mutation	SNP	C	A	A																															gtatgtccttgattcagcccCactgacaaagtctgcaattg																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:102270399C>A	uc001duf.2	-	6	903	c.832G>T	c.(832-834)GGG>TGG	p.G278W	OLFM3_uc001dug.2_Missense_Mutation_p.G258W|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.G183W|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	278	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		GATTCAGCCCCACTGACAAAG	0.368													27	109					2.14196e-07	2.41859e-07	1	0	A	102270399	A	A	102270399	3	1	50	1	0	0	0	0	1	0	0	0	10908	594	21	4	608	4	OLFM3	1	102270399	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	2	102270399	146980222	10	9889	23	2									
CELSR2	1952	broad.mit.edu	37	chr1	109811810	109811810	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcacggcgacagcgacggcAcccggagctgagccagggtg	8	2	18	13	5	0	1	0	1	0	0	0	4	0	2	2	5	3	3	2	5	0	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:109811810A>G	uc001dxa.3	+	20	6771	c.6710A>G	c.(6709-6711)CAC>CGC	p.H2237R		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2237	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CAGCGACGGCACCCGGAGCTG	0.682													13	53					0	0	0	0	G	109811810	G	G	109811810	3	3	50	1	0	0	0	0	1	0	0	0	3237	159	6	5	6788	5	CELSR2	1	109811810	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	7541411	109811810	139438811	11	9890											
CSDE1	7812	broad.mit.edu	37	chr1	115272925	115272925	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttttaggattggaaaaaGtggcttctttttctaccgtg	8	17	11	5	1	2	0	0	0	2	0	2	2	2	2	1	4	1	2	1	4	4	7			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:115272925G>T	uc001efk.2	-	12	1776	c.1310C>A	c.(1309-1311)ACT>AAT	p.T437N	CSDE1_uc001efi.2_Missense_Mutation_p.T483N|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.T406N|CSDE1_uc001efm.2_Missense_Mutation_p.T452N|CSDE1_uc009wgv.2_Missense_Mutation_p.T437N|CSDE1_uc001efn.2_Missense_Mutation_p.T406N	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	437					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATTGGAAAAAGTGGCTTCTTT	0.378													15	186					2.32078e-09	2.71053e-09	1	0	T	115272925	T	T	115272925	3	4	50	1	0	0	0	0	1	0	0	0	3946	1029	36	4	1122	4	CSDE1	1	115272925	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	5461115	115272925	133977696	12	9891											
OTUD7B	56957	broad.mit.edu	37	chr1	149915890	149915890	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcggttgtttgcatttggTctgagttgggggaaggcccc	4	14	16	7	1	1	1	0	1	1	0	2	2	1	2	2	5	1	5	2	5	1	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:149915890T>A	uc001etn.2	-	12	2754	c.2398A>T	c.(2398-2400)ACC>TCC	p.T800S		NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	800	A20-type.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			TTGCATTTGGTCTGAGTTGGG	0.557													68	205					0	0	0	0	A	149915890	A	A	149915890	3	1	50	1	0	0	0	0	1	0	0	0	11373	1667	58	5	137	5	OTUD7B	1	149915890	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	34642965	149915890	99334731	13	9892											
FLG	2312	broad.mit.edu	37	chr1	152277524	152277524	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtccaccagaggaagtctCtgcgtgacgagtgcctgatt	8	10	12	11	2	1	3	0	2	1	1	3	5	2	4	3	1	2	0	3	1	1	1	rs143421504		TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:152277524C>G	uc001ezu.1	-	3	9874	c.9838G>C	c.(9838-9840)GAG>CAG	p.E3280Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3280	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGAAGTCTCTGCGTGACGA	0.602									Ichthyosis				64	581					0	0	0	0	G	152277524	G	G	152277524	3	3	50	1	0	0	0	0	1	0	0	0	5954	922	32	2	2351	2	FLG	1	152277524	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	2361634	152277524	96973097	14	9893											
FLG	2312	broad.mit.edu	37	chr1	152282662	152282662	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtctagagctgccggccCgagtggaaggttcatggtga	8	9	16	8	2	2	2	1	1	1	1	2	4	2	3	2	4	2	2	2	4	2	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:152282662C>A	uc001ezu.1	-	3	4736	c.4700G>T	c.(4699-4701)CGG>CTG	p.R1567L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1567	Ser-rich.|Filaggrin 9.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.R1567W(1)		ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGCCGGCCCGAGTGGAAGG	0.582									Ichthyosis				79	321					1.49228e-48	2.01162e-48	1	0	A	152282662	A	A	152282662	3	1	50	1	0	0	0	0	1	0	0	0	5954	652	23	3	7489	3	FLG	1	152282662	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	5138	152282662	96967959	15	9894											
SHE	126669	broad.mit.edu	37	chr1	154459001	154459001	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatctgaggaggagactcAcggctgcttctccaggggca	9	7	15	10	1	3	2	1	1	2	1	4	5	3	4	1	6	1	3	1	6	0	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:154459001A>T	uc001ffb.2	-	4	1268	c.1181_splice	c.e4+1	p.P394_splice	SHE_uc001ffc.2_Splice_Site	NM_001010846	NP_001010846	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E											breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GAGGAGACTCACGGCTGCTTC	0.537													27	112					0	0	0	0	T	154459001	T	T	154459001	5	4	50	1	0	0	0	0	0	0	1	0	14341	173	6	5	316	5	SHE	1	154459001	Splice_Site	SNP	A	TCGA-CN-4739-01A-02D-1512-08	2176339	154459001	94791620	16	9895											
GPATCH4	54865	broad.mit.edu	37	chr1	156565514	156565514	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttctttttcttttttttggGgggcttgctctctgactgca	2	22	9	8	0	3	1	0	1	3	0	4	1	3	1	0	3	2	3	0	3	0	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:156565514G>C	uc001fpm.2	-	8	658	c.619C>G	c.(619-621)CCC>GCC	p.P207A	APOA1BP_uc010php.1_Intron|GPATCH4_uc001fpl.2_Missense_Mutation_p.P202A	NM_015590	NP_056405	Q5T3I0	GPTC4_HUMAN	G patch domain containing 4 isoform 1	202	Potential.					intracellular	nucleic acid binding			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTTTTTTTGGGGGGCTTGCTC	0.547													30	148					0	0	0	0	C	156565514	C	C	156565514	3	2	50	1	0	0	0	0	1	0	0	0	6631	1232	43	4	512	4	GPATCH4	1	156565514	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	2106513	156565514	92685107	17	9896											
PYHIN1	149628	broad.mit.edu	37	chr1	158906896	158906896	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgccggtttgggcaaactaAtagaattcttcaaagaaata	16	11	8	6	1	2	2	1	0	1	2	2	2	2	2	1	2	2	2	1	2	7	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:158906896A>G	uc001ftb.2	+	2	441	c.196A>G	c.(196-198)ATA>GTA	p.I66V	PYHIN1_uc001fta.3_Missense_Mutation_p.I66V|PYHIN1_uc001ftc.2_Missense_Mutation_p.I66V|PYHIN1_uc001ftd.2_Missense_Mutation_p.I66V|PYHIN1_uc001fte.2_Missense_Mutation_p.I66V	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	66	DAPIN.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					GGGCAAACTAATAGAATTCTT	0.383													31	92					0	0	0	0	G	158906896	G	G	158906896	3	3	50	1	0	0	0	0	1	0	0	0	12930	101	4	5	198	5	PYHIN1	1	158906896	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	2341382	158906896	90343725	18	9897											
CCDC19	25790	broad.mit.edu	37	chr1	159850410	159850410	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctgagccagcagttctgcTttctgtttctggttttcatc	4	18	8	11	0	4	1	1	1	3	0	6	1	5	1	2	1	3	5	2	1	0	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:159850410T>C	uc001fui.2	-	8	996	c.978A>G	c.(976-978)AAA>AAG	p.K326K	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Silent_p.K241K|CCDC19_uc001ful.2_Silent_p.K241K|CCDC19_uc009wtc.1_Silent_p.K312K	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	326	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			GCAGTTCTGCTTTCTGTTTCT	0.463													48	162					0	0	0	0	C	159850410	C	C	159850410	2	2	50	1	0	0	0	0	0	0	0	1	2808	1606	56	5		5	CCDC19	1	159850410	Silent	SNP	T	TCGA-CN-4739-01A-02D-1512-08	943514	159850410	89400211	19	9898											
SELP	6403	broad.mit.edu	37	chr1	169582194	169582194	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggaggcttatttgtccAgattccagaagccaagcatt	10	12	10	9	0	0	2	0	0	0	2	2	3	2	3	3	2	2	2	3	2	3	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:169582194A>T	uc001ggi.3	-	5	813	c.748T>A	c.(748-750)TGG>AGG	p.W250R	SELP_uc001ggh.2_Missense_Mutation_p.W85R|SELP_uc009wvr.2_Missense_Mutation_p.W250R	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	250	Extracellular (Potential).|Sushi 1.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TTATTTGTCCAGATTCCAGAA	0.458													32	105					0	0	0	0	T	169582194	T	T	169582194	3	4	50	1	0	0	0	0	1	0	0	0	14084	188	7	5	1792	5	SELP	1	169582194	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	9731784	169582194	79668427	20	9899											
XPR1	9213	broad.mit.edu	37	chr1	180780558	180780558	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagcctgcaccagcatggActacttttagagttggccta	10	10	9	12	0	0	1	0	0	0	1	0	2	0	2	3	2	4	3	3	2	3	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:180780558A>T	uc001goi.2	+	7	889	c.697A>T	c.(697-699)ACT>TCT	p.T233S	XPR1_uc009wxm.2_Missense_Mutation_p.T233S|XPR1_uc009wxn.2_Missense_Mutation_p.T233S	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	233	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						ACCAGCATGGACTACTTTTAG	0.328													49	135					0	0	0	0	T	180780558	T	T	180780558	3	4	50	1	0	0	0	0	1	0	0	0	17519	275	10	5	723	5	XPR1	1	180780558	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	11198364	180780558	68470063	21	9900											
CFHR5	81494	broad.mit.edu	37	chr1	196971751	196971751	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccagaagcaaaagaaatTgtatgtaaagatggacgatg	17	9	10	5	1	0	3	0	0	0	3	1	5	1	4	1	1	1	3	1	1	7	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:196971751T>A	uc001gts.3	+	8	1415	c.1287T>A	c.(1285-1287)ATT>ATA	p.I429I		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	429	Sushi 7.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						CAAAAGAAATTGTATGTAAAG	0.348													31	72					0	0	0	0	A	196971751	A	A	196971751	2	1	50	1	0	0	0	0	0	0	0	1	3303	1800	63	5		5	CFHR5	1	196971751	Silent	SNP	T	TCGA-CN-4739-01A-02D-1512-08	16191193	196971751	52278870	22	9901											
CFHR5	81494	broad.mit.edu	37	chr1	196973835	196973835	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccatctattaacaatggaGataccacctcattcccatta	13	12	3	13	0	2	1	1	0	1	1	4	2	4	1	4	1	2	0	4	1	5	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:196973835G>C	uc001gts.3	+	9	1503	c.1375G>C	c.(1375-1377)GAT>CAT	p.D459H		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	459	Sushi 8.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TAACAATGGAGATACCACCTC	0.398													56	191					0	0	0	0	C	196973835	C	C	196973835	3	2	50	1	0	0	0	0	1	0	0	0	3303	942	33	2	1409	2	CFHR5	1	196973835	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	2084	196973835	52276786	23	9902											
CRB1	23418	broad.mit.edu	37	chr1	197396747	197396747	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcacttatcaatatatccgTgtctggctagagcgcggcag	10	10	11	10	3	2	1	1	0	1	1	3	1	3	1	1	2	2	3	1	2	5	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:197396747T>A	uc001gtz.2	+	7	2427	c.2292T>A	c.(2290-2292)CGT>CGA	p.R764R	CRB1_uc010poz.1_Silent_p.R695R|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.R652R|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Silent_p.R245R|CRB1_uc001gub.1_Silent_p.R413R	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	764	Extracellular (Potential).|Laminin G-like 2.		R -> C (in RP12 and LCA8).		cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AATATATCCGTGTCTGGCTAG	0.428													21	57					0	0	0	0	A	197396747	A	A	197396747	2	1	50	1	0	0	0	0	0	0	0	1	3863	1683	59	5		5	CRB1	1	197396747	Silent	SNP	T	TCGA-CN-4739-01A-02D-1512-08	422912	197396747	51853874	24	9903											
NAV1	89796	broad.mit.edu	37	chr1	201758873	201758873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccttctctttcagttcacGgctcagtgctgtccctggcc	3	14	8	16	1	4	0	3	0	1	0	7	0	6	0	3	2	1	3	3	2	0	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:201758873G>A	uc001gwu.2	+	11	3519	c.3172G>A	c.(3172-3174)GGC>AGC	p.G1058S	NAV1_uc001gwv.1_Missense_Mutation_p.G566S|NAV1_uc001gww.1_Missense_Mutation_p.G667S|NAV1_uc001gwx.2_Missense_Mutation_p.G667S|NAV1_uc001gwy.1_Missense_Mutation_p.G439S	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1058					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						TTCAGTTCACGGCTCAGTGCT	0.517													12	148					0	0	0	0	A	201758873	A	A	201758873	3	1	50	1	0	0	0	0	1	0	0	0	10236	1116	39	1	3271	1	NAV1	1	201758873	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	4362126	201758873	47491748	25	9904											
RYR2	6262	broad.mit.edu	37	chr1	237993869	237993869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggataggcaatgattacttcGacacagtgccacatggcttt	11	11	10	9	1	0	1	0	1	0	0	1	3	0	2	1	3	2	2	1	3	3	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:237993869G>A	uc001hyl.1	+	103	14815	c.14695G>A	c.(14695-14697)GAC>AAC	p.D4899N	RYR2_uc010pyb.1_Intron	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4899					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGATTACTTCGACACAGTGCC	0.418													56	199					0	0	0	0	A	237993869	A	A	237993869	3	1	50	1	0	0	0	0	1	0	0	0	13834	1058	37	1	15105	1	RYR2	1	237993869	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	36234996	237993869	11256752	26	9905											
PLD5	200150	broad.mit.edu	37	chr1	242277263	242277263	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatactgcttggcatcatcTatcacactgtagatggcatc	11	12	7	11	0	3	1	2	0	1	1	4	1	3	1	0	2	2	4	0	2	3	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:242277263T>A	uc001hzn.1	-	7	1126	c.999A>T	c.(997-999)ATA>ATT	p.I333I	PLD5_uc001hzl.3_Silent_p.I271I|PLD5_uc001hzm.3_Silent_p.I123I|PLD5_uc001hzo.1_Silent_p.I241I			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	333						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TGGCATCATCTATCACACTGT	0.433													49	127					0	0	0	0	A	242277263	A	A	242277263	2	1	50	1	0	0	0	0	0	0	0	1	12104	1512	53	5		5	PLD5	1	242277263	Silent	SNP	T	TCGA-CN-4739-01A-02D-1512-08	4283394	242277263	6973358	27	9906											
TFB2M	64216	broad.mit.edu	37	chr1	246704441	246704441	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgagggtgcatgttaactacTttctcatcctcctgttttcc	6	17	7	11	0	1	1	1	1	1	0	5	1	4	1	3	1	3	3	3	1	2	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:246704441T>C	uc001ibn.2	-	8	1208	c.1083A>G	c.(1081-1083)AAA>AAG	p.K361K		NM_022366	NP_071761	Q9H5Q4	TFB2M_HUMAN	transcription factor B2, mitochondrial	361					positive regulation of transcription, DNA-dependent|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity			ovary(1)	1	all_cancers(71;4.25e-05)|all_epithelial(71;4.92e-06)|Ovarian(71;0.0254)|all_lung(81;0.0272)|Breast(184;0.0318)|Lung NSC(105;0.0376)		OV - Ovarian serous cystadenocarcinoma(106;0.00358)			TGTTAACTACTTTCTCATCCT	0.353													8	111					0	0	0	0	C	246704441	C	C	246704441	2	2	50	1	0	0	0	0	0	0	0	1	15860	1606	56	5		5	TFB2M	1	246704441	Silent	SNP	T	TCGA-CN-4739-01A-02D-1512-08	4427178	246704441	2546180	28	9907											
CNST	163882	broad.mit.edu	37	chr1	246823595	246823595	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaacacaaaccatctaagcGaagagtgagattccaagaaa	19	5	8	9	1	1	3	0	1	1	3	2	5	2	3	2	0	3	1	2	0	6	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:246823595G>T	uc001ibp.2	+	10	2309	c.1931G>T	c.(1930-1932)CGA>CTA	p.R644L		NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	644					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						CCATCTAAGCGAAGAGTGAGA	0.438													66	172					1.84395e-34	2.44264e-34	1	0	T	246823595	T	T	246823595	3	4	50	1	0	0	0	0	1	0	0	0	3649	1058	37	3	1980	3	CNST	1	246823595	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	119154	246823595	2427026	29	9908											
ZNF695	57116	broad.mit.edu	37	chr1	247163376	247163376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atccctgaatgccaatagtcCctgaaaaagaaaacatattt	17	10	5	9	0	0	3	0	2	0	1	2	3	2	3	3	0	2	0	3	0	8	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr1:247163376C>T	uc009xgu.2	-	2	149	c.4G>A	c.(4-6)GGA>AGA	p.G2R	ZNF695_uc001ica.2_RNA|ZNF695_uc001icb.1_RNA|ZNF695_uc009xgt.1_RNA|ZNF695_uc001ibx.2_Missense_Mutation_p.G2R|ZNF695_uc001iby.2_RNA|ZNF695_uc001icc.2_Missense_Mutation_p.G2R	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	2					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GCCAATAGTCCCTGAAAAAGA	0.453													22	52					0	0	0	0	T	247163376	T	T	247163376	3	4	50	1	0	0	0	0	1	0	0	0	18165	637	22	4	1555	4	ZNF695	1	247163376	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	339781	247163376	2087245	30	9909											
KCNF1	3754	broad.mit.edu	37	chr2	11052775	11052775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgactacgaccccggcaagCgcgagttctactttgacagg	10	7	11	13	5	1	1	0	1	1	0	1	4	1	1	2	2	3	2	2	2	3	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:11052775C>T	uc002rax.2	+	1	713	c.223C>T	c.(223-225)CGC>TGC	p.R75C		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	75	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CCCCGGCAAGCGCGAGTTCTA	0.592													10	47					0	0	0	0	T	11052775	T	T	11052775	3	4	50	1	0	0	0	0	1	0	0	0	8065	768	27	1	225	1	KCNF1	2	11052775	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		11052775	232146598	31	9910											
ROCK2	9475	broad.mit.edu	37	chr2	11332363	11332363	+	Frame_Shift_Del	DEL	A	-	-																															gttctaggagatgatcgggcAaaagggtctggagctggggg																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:11332363delA	uc002rbd.1	-	32	4523	c.4074delT	c.(4072-4074)TTTfs	p.F1358fs		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	1358					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		ATGATCGGGCAAAAGGGTCTG	0.433													---	---	---								-	11332363	-	-	11332363	7	5	50	1	0	1	0	1	0	0	0	0	13583	127	5	0	100	0	ROCK2	2	11332363	Frame_Shift_Del	DEL	A	TCGA-CN-4739-01A-02D-1512-08	279588	11332363	231867010	32	9911											
CAD	790	broad.mit.edu	37	chr2	27465288	27465288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggagctgggaactgtcaatgGcatgacggtgagggtggtgg	8	8	20	5	1	1	2	1	2	0	0	1	4	1	4	0	7	2	2	0	7	2	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:27465288G>A	uc002rji.2	+	40	6377	c.6215G>A	c.(6214-6216)GGC>GAC	p.G2072D	CAD_uc010eyw.2_Missense_Mutation_p.G2009D	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	2072	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	ACTGTCAATGGCATGACGGTG	0.612													3	47					0	0	0	0	A	27465288	A	A	27465288	3	1	50	1	0	0	0	0	1	0	0	0	2577	1203	42	4	6373	4	CAD	2	27465288	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	16132925	27465288	215734085	33	9912											
TMEM178	130733	broad.mit.edu	37	chr2	39934301	39934301	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagagcttgacccagcacgtGgctggactcctgttcctcat	7	10	11	13	1	1	2	1	1	0	1	3	4	3	3	3	2	2	4	3	2	0	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:39934301G>A	uc002rrt.2	+	3	652	c.627G>A	c.(625-627)GTG>GTA	p.V209V	TMEM178_uc010fam.1_Intron	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	209	Helical; (Potential).					integral to membrane					0		all_hematologic(82;0.248)				CCCAGCACGTGGCTGGACTCC	0.602													3	58					0	0	0	0	A	39934301	A	A	39934301	2	1	50	1	0	0	0	0	0	0	0	1	16161	1335	47	4		4	TMEM178	2	39934301	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	12469013	39934301	203265072	34	9913											
SLC8A1	6546	broad.mit.edu	37	chr2	40366736	40366736	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcaaacaggaccttccagaAcacagtcagaaagtgcatca	16	5	9	11	0	2	2	2	0	0	2	3	3	3	3	2	2	3	2	2	2	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:40366736A>G	uc002rrx.2	-	9	2374	c.2350T>C	c.(2350-2352)TTC>CTC	p.F784L	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Missense_Mutation_p.F779L|SLC8A1_uc002rrz.2_Missense_Mutation_p.F771L|SLC8A1_uc002rsa.2_Missense_Mutation_p.F748L|SLC8A1_uc002rsd.3_Missense_Mutation_p.F748L	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	784	Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ACCTTCCAGAACACAGTCAGA	0.498													41	120					0	0	0	0	G	40366736	G	G	40366736	3	3	50	1	0	0	0	0	1	0	0	0	14770	43	2	5	579	5	SLC8A1	2	40366736	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	432435	40366736	202832637	35	9914											
RETSAT	54884	broad.mit.edu	37	chr2	85581597	85581597	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagaggacggccagcagcaGcacagccaggagcagcacca	13	0	14	14	1	0	1	0	0	0	1	0	3	0	3	3	3	6	6	3	3	0	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:85581597G>A	uc002spd.2	-	1	225	c.34C>T	c.(34-36)CTG>TTG	p.L12L	ELMOD3_uc010fgg.2_5'Flank|ELMOD3_uc002spf.3_5'Flank|ELMOD3_uc002spg.3_5'Flank|ELMOD3_uc002sph.3_5'Flank|ELMOD3_uc010ysn.1_5'Flank|ELMOD3_uc010yso.1_5'Flank|ELMOD3_uc010ysp.1_5'Flank|RETSAT_uc010ysm.1_Silent_p.L12L|RETSAT_uc010fgf.2_Silent_p.L12L	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	12					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	GCCAGCAGCAGCACAGCCAGG	0.622													31	59					0	0	0	0	A	85581597	A	A	85581597	2	1	50	1	0	0	0	0	0	0	0	1	13303	962	34	4		4	RETSAT	2	85581597	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	45214861	85581597	157617776	36	9915											
EDAR	10913	broad.mit.edu	37	chr2	109527277	109527277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgctcacttgggcctccaCgctcttccccgggtggctgg	2	11	12	16	2	2	0	1	0	1	0	4	0	4	0	4	4	1	3	4	4	0	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:109527277C>T	uc002teq.3	-	8	1116	c.685G>A	c.(685-687)GTG>ATG	p.V229M	EDAR_uc010fjn.2_Missense_Mutation_p.V261M|EDAR_uc010yws.1_Missense_Mutation_p.V261M	NM_022336	NP_071731	Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor precursor	229	Cytoplasmic (Potential).				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			skin(1)	1						TGGGCCTCCACGCTCTTCCCC	0.632													6	64					0	0	0	0	T	109527277	T	T	109527277	3	4	50	1	0	0	0	0	1	0	0	0	4927	536	19	1	681	1	EDAR	2	109527277	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	23945680	109527277	133672096	37	9916											
THSD7B	80731	broad.mit.edu	37	chr2	138169326	138169326	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggcagaagggagcctcaccGaggactgcgggtacaagcag	12	3	16	10	2	1	1	1	0	0	1	1	4	1	3	2	4	4	3	2	4	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:138169326G>A	uc002tva.1	+	13	2750	c.2750G>A	c.(2749-2751)CGA>CAA	p.R917Q	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.R807Q	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GAGCCTCACCGAGGACTGCGG	0.488													6	150					0	0	0	0	A	138169326	A	A	138169326	3	1	50	1	0	0	0	0	1	0	0	0	15946	1058	37	1	2800	1	THSD7B	2	138169326	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	28642049	138169326	105030047	38	9917											
LRP1B	53353	broad.mit.edu	37	chr2	141116461	141116461	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatttgctccgactgtaggCatattctgttatttctgcat	8	17	7	9	1	2	0	0	0	2	0	3	1	3	0	1	1	2	5	1	1	3	6	rs145962775		TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:141116461C>G	uc002tvj.1	-	73	12158	c.11186G>C	c.(11185-11187)TGC>TCC	p.C3729S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3729	Extracellular (Potential).|LDL-receptor class A 31.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CGACTGTAGGCATATTCTGTT	0.383										TSP Lung(27;0.18)			48	123					0	0	0	0	G	141116461	G	G	141116461	3	3	50	1	0	0	0	0	1	0	0	0	9005	710	25	4	2689	4	LRP1B	2	141116461	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	2947135	141116461	102082912	39	9918											
LRP1B	53353	broad.mit.edu	37	chr2	141299474	141299474	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctcttcttccccagtccgAccagaatatataattgtcat	11	13	5	12	1	3	1	1	0	2	1	5	2	5	1	4	0	1	1	4	0	4	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:141299474A>T	uc002tvj.1	-	44	8233	c.7261T>A	c.(7261-7263)TCG>ACG	p.S2421T		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2421	Extracellular (Potential).|LDL-receptor class B 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCCCAGTCCGACCAGAATATA	0.388										TSP Lung(27;0.18)			40	106					0	0	0	0	T	141299474	T	T	141299474	3	4	50	1	0	0	0	0	1	0	0	0	9005	275	10	5	6730	5	LRP1B	2	141299474	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	183013	141299474	101899899	40	9919											
LRP1B	53353	broad.mit.edu	37	chr2	141643801	141643801	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgaaaatcaagtgctatTgtgtttctcaatccaggaac	14	12	8	7	0	2	1	2	1	1	0	4	2	3	2	1	1	2	2	1	1	7	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:141643801T>A	uc002tvj.1	-	24	4842	c.3870A>T	c.(3868-3870)ACA>ACT	p.T1290T	LRP1B_uc010fnl.1_Silent_p.T472T	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1290	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAAGTGCTATTGTGTTTCTCA	0.358										TSP Lung(27;0.18)			34	95					0	0	0	0	A	141643801	A	A	141643801	2	1	50	1	0	0	0	0	0	0	0	1	9005	1799	63	5		5	LRP1B	2	141643801	Silent	SNP	T	TCGA-CN-4739-01A-02D-1512-08	344327	141643801	101555572	41	9920											
CYTIP	9595	broad.mit.edu	37	chr2	158283872	158283872	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aattaaattacctttaaaacCtgcagctttgcttcaagctc	13	14	4	10	0	1	0	1	0	0	0	2	0	1	0	2	0	6	4	2	0	7	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:158283872C>T	uc002tzj.1	-	6	609	c.537G>A	c.(535-537)CAG>CAA	p.Q179Q	CYTIP_uc010zcl.1_Silent_p.Q73Q	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	179	Interaction with CYTH1.|Potential.				regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						CCTTTAAAACCTGCAGCTTTG	0.363													9	28					0	0	0	0	T	158283872	T	T	158283872	2	4	50	1	0	0	0	0	0	0	0	1	4224	680	24	4		4	CYTIP	2	158283872	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	16640071	158283872	84915501	42	9921											
XIRP2	129446	broad.mit.edu	37	chr2	168103683	168103683	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gacctggaaacatcactaagGtctttgaaagaagcacaaag	17	7	9	8	0	2	2	1	1	1	1	2	4	2	3	1	2	2	1	1	2	5	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:168103683G>T	uc002udx.2	+	8	5799	c.5781G>T	c.(5779-5781)AGG>AGT	p.R1927S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R1752S|XIRP2_uc010fpq.2_Missense_Mutation_p.R1705S|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1752	Potential.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CATCACTAAGGTCTTTGAAAG	0.363													19	45					2.35188e-11	2.83337e-11	1	0	T	168103683	T	T	168103683	3	4	50	1	0	0	0	0	1	0	0	0	17498	1252	44	4	5811	4	XIRP2	2	168103683	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	9819811	168103683	75095690	43	9922											
GMPPA	29926	broad.mit.edu	37	chr2	220369977	220369977	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcaccaggcttgtggccaggGgcaggtaccatccgcctaga	8	7	13	13	1	1	1	1	0	0	1	2	1	2	1	5	5	1	3	5	5	2	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:220369977G>A	uc002vlr.2	+	8	716	c.648G>A	c.(646-648)GGG>GGA	p.G216G	GMPPA_uc002vls.2_Silent_p.G216G|GMPPA_uc002vlt.2_Silent_p.G216G|GMPPA_uc002vlu.2_Silent_p.G216G|GMPPA_uc002vlv.2_Silent_p.G216G|GMPPA_uc002vlw.2_RNA|GMPPA_uc002vlx.2_Silent_p.G216G	NM_013335	NP_037467	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	216					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		TGTGGCCAGGGGCAGGTACCA	0.577													7	52					0	0	0	0	A	220369977	A	A	220369977	2	1	50	1	0	0	0	0	0	0	0	1	6531	1219	43	4		4	GMPPA	2	220369977	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	52266294	220369977	22829396	44	9923											
PAX3	5077	broad.mit.edu	37	chr2	223158889	223158889	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaggcgccaccgcttacctcGctcgctcaggatgccgtcga	7	7	11	16	6	1	0	1	0	0	0	4	2	1	1	4	2	2	3	4	2	2	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr2:223158889G>T	uc010fwo.2	-	4	949	c.583C>A	c.(583-585)CGA>AGA	p.R195R	PAX3_uc002vmt.1_Silent_p.R195R|PAX3_uc002vmy.1_Silent_p.R194R|PAX3_uc002vmv.1_Silent_p.R195R|PAX3_uc002vmw.1_Silent_p.R195R|PAX3_uc002vmx.1_Silent_p.R195R|PAX3_uc002vmz.1_Silent_p.R195R|PAX3_uc002vna.1_Silent_p.R195R	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	195					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGCTTACCTCGCTCGCTCAGG	0.612			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						20	176					2.37509e-13	2.93056e-13	1	0	T	223158889	T	T	223158889	2	4	50	1	0	0	0	0	0	0	0	1	11534	1095	38	3		3	PAX3	2	223158889	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	2788912	223158889	20040484	45	9924											
ULK4	54986	broad.mit.edu	37	chr3	41439704	41439704	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccatacagctgaaccagtaTagacaggcacttggatgaaa	15	8	9	9	0	0	3	0	2	0	1	1	4	1	4	2	2	3	3	2	2	5	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:41439704T>C	uc003ckv.3	-	35	3745	c.3544A>G	c.(3544-3546)ATA>GTA	p.I1182V		NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	1182	HEAT 4.						ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TGAACCAGTATAGACAGGCAC	0.393													28	105					0	0	0	0	C	41439704	C	C	41439704	3	2	50	1	0	0	0	0	1	0	0	0	17046	1406	49	5	295	5	ULK4	3	41439704	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08		41439704	156582726	46	9925											
ADAMTS9	56999	broad.mit.edu	37	chr3	64582637	64582637	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgacatacaacaacacgccGctgggatccgccagcacagg	12	4	10	15	3	0	1	0	1	0	0	1	2	1	2	3	2	4	2	3	2	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:64582637G>A	uc003dmg.2	-	27	4080	c.4048C>T	c.(4048-4050)CGG>TGG	p.R1350W	ADAMTS9_uc011bfo.1_Missense_Mutation_p.R1322W|ADAMTS9_uc003dmh.1_Missense_Mutation_p.R1179W|ADAMTS9_uc011bfp.1_Missense_Mutation_p.R261W	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1350	TSP type-1 9.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ACAACACGCCGCTGGGATCCG	0.498													24	73					0	0	0	0	A	64582637	A	A	64582637	3	1	50	1	0	0	0	0	1	0	0	0	273	1086	38	1	1811	1	ADAMTS9	3	64582637	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	23142933	64582637	133439793	47	9926											
MAGI1	9223	broad.mit.edu	37	chr3	65350391	65350391	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgagattcctgctttggtttGgtggtattcctgccaaagtg	6	16	12	7	0	0	1	0	1	0	1	2	2	2	1	3	3	2	3	3	3	2	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:65350391G>A	uc003dmn.2	-	20	3826	c.3300C>T	c.(3298-3300)ACC>ACT	p.T1100T	MAGI1_uc003dmm.2_Silent_p.T1128T|MAGI1_uc003dmo.2_Silent_p.T1129T|MAGI1_uc003dmp.2_Silent_p.T1033T	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1129	PDZ 6.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GCTTTGGTTTGGTGGTATTCC	0.393													29	97					0	0	0	0	A	65350391	A	A	65350391	2	1	50	1	0	0	0	0	0	0	0	1	9243	1335	47	4		4	MAGI1	3	65350391	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	767754	65350391	132672039	48	9927											
RYBP	23429	broad.mit.edu	37	chr3	72495696	72495696	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgctgcatttaaaggcttCagcactgtttctgaaggtgc	9	13	11	8	0	2	1	1	1	1	0	2	2	2	1	0	2	4	5	0	2	3	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:72495696C>A	uc003dpe.2	-	1	196	c.79G>T	c.(79-81)GAA>TAA	p.E27*		NM_012234	NP_036366	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	37	RanBP2-type.				apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding				0		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		TTAAAGGCTTCAGCACTGTTT	0.468													4	24					0.000602214	0.00063544	1	0	A	72495696	A	A	72495696	4	1	50	1	0	0	0	0	0	1	0	0	13831	835	29	2	593	2	RYBP	3	72495696	Nonsense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	7145305	72495696	125526734	49	9928											
PDZRN3	23024	broad.mit.edu	37	chr3	73433986	73433986	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagctctcgtcattacgggtGctctcgtcggtccgccccac	4	10	11	16	5	3	0	1	0	2	0	7	1	4	0	3	2	3	2	3	2	1	1	rs151244384		TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:73433986G>T	uc003dpl.1	-	10	1827	c.1731C>A	c.(1729-1731)AGC>AGA	p.S577R	PDZRN3_uc011bgh.1_Missense_Mutation_p.S234R|PDZRN3_uc010hoe.1_Missense_Mutation_p.S275R|PDZRN3_uc011bgf.1_Missense_Mutation_p.S294R|PDZRN3_uc011bgg.1_Missense_Mutation_p.S297R	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	577							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CATTACGGGTGCTCTCGTCGG	0.622													12	42					4.3838e-07	4.93178e-07	1	0	T	73433986	T	T	73433986	3	4	50	1	0	0	0	0	1	0	0	0	11763	1310	46	4	1473	4	PDZRN3	3	73433986	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	938290	73433986	124588444	50	9929											
EPHA3	2042	broad.mit.edu	37	chr3	89521735	89521735	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcacgggtgtggagtacAgttcttgtgacacaatagcc	9	12	11	9	1	3	1	1	1	2	0	3	2	3	2	1	2	2	2	1	2	3	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:89521735A>G	uc003dqy.2	+	16	3037	c.2812A>G	c.(2812-2814)AGT>GGT	p.S938G	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	938	Cytoplasmic (Potential).|SAM.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGTGGAGTACAGTTCTTGTGA	0.408										TSP Lung(6;0.00050)			28	124					0	0	0	0	G	89521735	G	G	89521735	3	3	50	1	0	0	0	0	1	0	0	0	5192	188	7	5	2900	5	EPHA3	3	89521735	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	16087749	89521735	108500695	51	9930											
DCBLD2	131566	broad.mit.edu	37	chr3	98520447	98520447	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagaccacgtgagttacctgCccggtcccagtaaggtaagt	11	8	11	11	2	0	2	0	1	0	1	1	2	1	2	4	2	2	3	4	2	4	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:98520447C>G	uc003dtd.2	-	14	2080	c.1717G>C	c.(1717-1719)GCA>CCA	p.A573P	DCBLD2_uc003dte.2_Missense_Mutation_p.A573P	NM_080927	NP_563615	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	573	Cytoplasmic (Potential).				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3						GAGTTACCTGCCCGGTCCCAG	0.448													10	19					0	0	0	0	G	98520447	G	G	98520447	3	3	50	1	0	0	0	0	1	0	0	0	4298	739	26	4	622	4	DCBLD2	3	98520447	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	8998712	98520447	99501983	52	9931											
MORC1	27136	broad.mit.edu	37	chr3	108725922	108725922	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgacagtgatttcgtccActggtataaattgaggcttt	11	14	10	6	1	0	3	0	3	0	0	2	3	1	3	1	2	0	2	1	2	4	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:108725922A>G	uc003dxl.2	-	18	1808	c.1721T>C	c.(1720-1722)GTG>GCG	p.V574A	MORC1_uc011bhn.1_Intron	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	574					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						GATTTCGTCCACTGGTATAAA	0.363													24	108					0	0	0	0	G	108725922	G	G	108725922	3	3	50	1	0	0	0	0	1	0	0	0	9754	159	6	5	1277	5	MORC1	3	108725922	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	10205475	108725922	89296508	53	9932											
DPPA2	151871	broad.mit.edu	37	chr3	109028054	109028054	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccgagttgttgacaccagTcccgcaaagtgtcccgacac	11	7	9	14	3	0	1	0	1	0	0	2	3	2	1	4	0	1	3	4	0	2	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:109028054T>C	uc003dxo.2	-	4	552	c.305A>G	c.(304-306)GAC>GGC	p.D102G		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	102	SAP.					nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						TTGACACCAGTCCCGCAAAGT	0.443													13	529					0	0	0	0	C	109028054	C	C	109028054	3	2	50	1	0	0	0	0	1	0	0	0	4756	1667	58	5	611	5	DPPA2	3	109028054	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	302132	109028054	88994376	54	9933											
ARHGAP31	57514	broad.mit.edu	37	chr3	119135065	119135065	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtttttaccagcctcagcGgagatcagtaattctggatg	9	13	10	9	1	3	1	2	0	1	1	3	3	3	2	2	2	3	2	2	2	2	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:119135065G>A	uc003ecj.3	+	12	4821	c.4289G>A	c.(4288-4290)CGG>CAG	p.R1430Q		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1430					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						CAGCCTCAGCGGAGATCAGTA	0.448													9	107					0	0	0	0	A	119135065	A	A	119135065	3	1	50	1	0	0	0	0	1	0	0	0	880	1116	39	1	4335	1	ARHGAP31	3	119135065	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	10107011	119135065	78887365	55	9934											
PARP14	54625	broad.mit.edu	37	chr3	122437687	122437688	+	Frame_Shift_Ins	INS	-	A	A																															aggatgcaaggagagaaaagINSaaaaaaacagttgatgtcaa																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:122437687_122437688insA	uc003efq.3	+	14	4748_4749	c.4689_4690insA	c.(4687-4692)AAGAAAfs	p.K1563fs	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Frame_Shift_Ins_p.K1280fs|PARP14_uc003efs.1_Frame_Shift_Ins_p.K1280fs	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1563_1564	WWE.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		GGAGAGAAAAGAAAAAAACAGT	0.366													---	---	---								A	122437688	A	A	122437687	7	5	50	1	0	1	1	0	0	0	0	0	11512	933	33	0	4743	0	PARP14	3	122437687	Frame_Shift_Ins	INS	-	TCGA-CN-4739-01A-02D-1512-08	3302622	122437687	75584743	56	9935											
MCM2	4171	broad.mit.edu	37	chr3	127337882	127337882	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tatcttaggacgagatgctgGcccgcttcgtggtgggcagc	6	10	15	10	3	1	1	0	0	1	1	2	3	1	2	1	4	2	3	1	4	2	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:127337882G>A	uc003ejp.2	+	13	2083	c.2026G>A	c.(2026-2028)GCC>ACC	p.A676T	MCM2_uc011bkm.1_Missense_Mutation_p.A546T|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Missense_Mutation_p.A629T	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	676	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						CGAGATGCTGGCCCGCTTCGT	0.632													7	16					0	0	0	0	A	127337882	A	A	127337882	3	1	50	1	0	0	0	0	1	0	0	0	9439	1203	42	4	2076	4	MCM2	3	127337882	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	4900195	127337882	70684548	57	9936											
IFT80	57560	broad.mit.edu	37	chr3	160095273	160095273	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcaagtactgctccacaGtgagcttctacacttttttc	8	14	6	13	0	1	1	0	1	1	0	3	1	2	1	2	0	5	4	2	0	3	6	rs137853115		TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:160095273G>A	uc011boy.1	-	4	748	c.315C>T	c.(313-315)CAC>CAT	p.H105H	IFT80_uc003fda.2_Intron|IFT80_uc003fdb.1_5'UTR|IFT80_uc003fdd.1_5'UTR|IFT80_uc003fde.1_5'UTR	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	105	WD 2.		H -> Q (in ATD2).			cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CTGCTCCACAGTGAGCTTCTA	0.303													81	166					0	0	0	0	A	160095273	A	A	160095273	2	1	50	1	0	0	0	0	0	0	0	1	7603	1020	36	4		4	IFT80	3	160095273	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	32757391	160095273	37927157	58	9937											
SI	6476	broad.mit.edu	37	chr3	164700056	164700056	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtagtgtcttcattaaaaGgaagcgaatttttatttccg	11	16	9	5	2	2	0	1	0	1	0	3	2	3	1	1	2	1	1	1	2	6	7			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:164700056G>A	uc003fei.2	-	47	5452	c.5390C>T	c.(5389-5391)CCT>CTT	p.P1797L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1797	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTCATTAAAAGGAAGCGAATT	0.358										HNSCC(35;0.089)			33	89					0	0	0	0	A	164700056	A	A	164700056	3	1	50	1	0	0	0	0	1	0	0	0	14362	1000	35	4	101	4	SI	3	164700056	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	4604783	164700056	33322374	59	9938											
PIK3CA	5290	broad.mit.edu	37	chr3	178922319	178922319	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcgaacaggtatctaccatgGaggagaacccttatgtgaca	13	9	10	9	1	1	2	0	1	1	1	2	5	1	3	2	3	3	1	2	3	5	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:178922319G>C	uc003fjk.2	+	6	1245	c.1088G>C	c.(1087-1089)GGA>GCA	p.G363A		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	363	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATCTACCATGGAGGAGAACCC	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			52	177					0	0	0	0	C	178922319	C	C	178922319	3	2	50	1	0	0	0	0	1	0	0	0	11968	1174	41	2	1106	2	PIK3CA	3	178922319	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	14222263	178922319	19100111	60	9939											
TMEM41A	90407	broad.mit.edu	37	chr3	185209390	185209390	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcaattgcagatgtttctGactaaattttttaatgaggg	12	17	8	4	0	2	3	1	2	1	1	2	3	2	3	0	1	1	2	0	1	4	7			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr3:185209390G>C	uc003fpj.2	-	5	826	c.730C>G	c.(730-732)CAG>GAG	p.Q244E	TMEM41A_uc003fpk.2_3'UTR	NM_080652	NP_542383	Q96HV5	TM41A_HUMAN	transmembrane protein 41A precursor	244						integral to membrane					0	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AGATGTTTCTGACTAAATTTT	0.408													5	192					0	0	0	0	C	185209390	C	C	185209390	3	2	50	1	0	0	0	0	1	0	0	0	16230	1299	45	2	68	2	TMEM41A	3	185209390	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	6287071	185209390	12813040	61	9940											
SLIT2	9353	broad.mit.edu	37	chr4	20618727	20618727	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtgcccatggcacatgccagCccagcagccaggcaggcttc	8	5	12	16	0	0	0	0	0	0	0	1	0	0	0	4	3	5	4	4	3	0	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr4:20618727C>A	uc003gpr.1	+	35	4246	c.4042C>A	c.(4042-4044)CCC>ACC	p.P1348T	SLIT2_uc003gps.1_Missense_Mutation_p.P1340T	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1348	EGF-like 7.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						CACATGCCAGCCCAGCAGCCA	0.577													11	34					3.86212e-05	4.19081e-05	1	0	A	20618727	A	A	20618727	3	1	50	1	0	0	0	0	1	0	0	0	14804	739	26	4	4180	4	SLIT2	4	20618727	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		20618727	170535549	62	9941											
DCAF4L1	285429	broad.mit.edu	37	chr4	41983735	41983735	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggacggaacttcctgtcaCggaaaagaacatcctgtcac	12	7	9	13	3	2	1	2	0	0	1	4	4	4	4	3	3	2	0	3	3	4	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr4:41983735C>T	uc003gwk.2	+	1	23	c.-74C>T	c.(-76--72)CACGG>CATGG			NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B											skin(1)	1						CTTCCTGTCACGGAAAAGAAC	0.398													4	20					0	0	0	0	T	41983735	T	T	41983735	1	4	50	1	0	0	0	0	0	0	0	0	4288	551	19	1		1	DCAF4L1	4	41983735	Translation_Start_Site	SNP	C	TCGA-CN-4739-01A-02D-1512-08	21365008	41983735	149170541	63	9942											
SMARCAD1	56916	broad.mit.edu	37	chr4	95197554	95197554	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacggctgaaacttaattacGcaatttttgatgagggccat	12	12	10	7	2	0	3	0	3	0	0	0	4	0	3	1	2	2	2	1	2	4	4	rs150935622		TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr4:95197554G>C	uc003htc.3	+	15	2128	c.1873G>C	c.(1873-1875)GCA>CCA	p.A625P	SMARCAD1_uc003htb.3_Missense_Mutation_p.A625P|SMARCAD1_uc003htd.3_Missense_Mutation_p.A625P|SMARCAD1_uc010ila.2_Missense_Mutation_p.A488P|SMARCAD1_uc011cdw.1_Missense_Mutation_p.A195P	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	625	Helicase ATP-binding.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		ACTTAATTACGCAATTTTTGA	0.383													21	79					0	0	0	0	C	95197554	C	C	95197554	3	2	50	1	0	0	0	0	1	0	0	0	14836	1087	38	3	1927	3	SMARCAD1	4	95197554	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	53213819	95197554	95956722	64	9943											
AGXT2L1	64850	broad.mit.edu	37	chr4	109681435	109681435	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcactattttgatgggatcCgatgcaaagaaaactttgca	13	12	8	8	1	1	2	1	1	0	1	2	4	2	3	1	1	3	2	1	1	4	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr4:109681435C>T	uc003hzc.2	-	2	265	c.84G>A	c.(82-84)TCG>TCA	p.S28S	AGXT2L1_uc010imc.2_Silent_p.S28S|AGXT2L1_uc011cfm.1_5'UTR|AGXT2L1_uc011cfn.1_Intron|AGXT2L1_uc011cfo.1_Intron	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	28					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		TGATGGGATCCGATGCAAAGA	0.428													55	130					0	0	0	0	T	109681435	T	T	109681435	2	4	50	1	0	0	0	0	0	0	0	1	406	639	23	1		1	AGXT2L1	4	109681435	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	14483881	109681435	81472841	65	9944											
NDST3	9348	broad.mit.edu	37	chr4	118974943	118974943	+	Translation_Start_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgagtcctgatcaagtgatAcaaatgagctgcaatggtga	13	10	12	6	0	1	5	1	5	0	0	2	5	2	5	1	1	3	2	1	1	4	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr4:118974943A>G	uc003ibx.2	+	2	281	c.-122A>G	c.(-124--120)ATACA>ATGCA		NDST3_uc011cgf.1_Translation_Start_Site|NDST3_uc003ibw.2_Translation_Start_Site	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan							Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						ATCAAGTGATACAAATGAGCT	0.333													6	26					0	0	0	0	G	118974943	G	G	118974943	1	3	50	1	0	0	0	0	0	0	0	0	10311	406	14	5		5	NDST3	4	118974943	Translation_Start_Site	SNP	A	TCGA-CN-4739-01A-02D-1512-08	9293508	118974943	72179333	66	9945											
MAB21L2	10586	broad.mit.edu	37	chr4	151504465	151504465	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtggacgacggctcgctgcCcggctgcgcagtgctcaaac	6	6	14	15	6	1	0	1	0	0	0	2	2	1	1	1	3	4	5	1	3	1	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr4:151504465C>A	uc003ilw.2	+	1	1389	c.284C>A	c.(283-285)CCC>CAC	p.P95H	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	95					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		GGCTCGCTGCCCGGCTGCGCA	0.602													11	91					1.08611e-07	1.24011e-07	1	0	A	151504465	A	A	151504465	3	1	50	1	0	0	0	0	1	0	0	0	9193	623	22	4	286	4	MAB21L2	4	151504465	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	32529522	151504465	39649811	67	9946											
DDX60	55601	broad.mit.edu	37	chr4	169157507	169157507	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagcttttccataacgtcttGagaaaaatgttttgagccta	12	15	7	7	1	1	2	0	2	1	1	2	3	2	2	2	0	3	2	2	0	5	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr4:169157507G>C	uc003irp.2	-	33	4721	c.4429C>G	c.(4429-4431)CAA>GAA	p.Q1477E		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1477							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		ATAACGTCTTGAGAAAAATGT	0.303													12	90					0	0	0	0	C	169157507	C	C	169157507	3	2	50	1	0	0	0	0	1	0	0	0	4395	1299	45	2	733	2	DDX60	4	169157507	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	17653042	169157507	21996769	68	9947											
C4orf41	60684	broad.mit.edu	37	chr4	184633772	184633772	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacagggtcgactcatggAtgatacctctattgctgctg	8	11	11	11	1	2	1	1	1	1	0	3	3	2	2	2	2	3	2	2	2	2	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr4:184633772A>G	uc003ivx.2	+	30	3553	c.3377A>G	c.(3376-3378)GAT>GGT	p.D1126G	C4orf41_uc003ivw.2_Silent_p.G1086G|C4orf41_uc010isc.2_Silent_p.G430G|C4orf41_uc003ivy.2_Missense_Mutation_p.D732G	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	1126											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		CGACTCATGGATGATACCTCT	0.393													26	253					0	0	0	0	G	184633772	G	G	184633772	3	3	50	1	0	0	0	0	1	0	0	0	2280	333	12	5	3491	5	C4orf41	4	184633772	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	15476265	184633772	6520504	69	9948											
CLPTM1L	81037	broad.mit.edu	37	chr5	1330403	1330403	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggaactcacctcaatggCggctccaacacccgccggga	9	4	10	18	4	2	0	2	0	0	0	3	2	3	2	5	4	2	1	5	4	3	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:1330403C>T	uc003jch.2	-	9	1118	c.1072G>A	c.(1072-1074)GCC>ACC	p.A358T	CLPTM1L_uc003jcg.2_Intron	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	CLPTM1-like	358	Helical; (Potential).				apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		ACCTCAATGGCGGCTCCAACA	0.622													56	71					0	0	0	0	T	1330403	T	T	1330403	3	4	50	1	0	0	0	0	1	0	0	0	3570	768	27	1	580	1	CLPTM1L	5	1330403	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		1330403	179584857	70	9949											
IRX1	79192	broad.mit.edu	37	chr5	3600720	3600721	+	Splice_Site	INS	-	AG	AG																															tgcctcttccgatctctcgcINSagagagagacctcgtcccca																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:3600720_3600721insAG	uc003jde.2	+	3	1365	c.1313_splice	c.e3-2	p.E438_splice		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						CGATCTCTCGCAGAGAGAGACC	0.614													---	---	---								AG	3600721	AG	AG	3600720	8	5	50	1	0	1	1	0	0	0	1	0	7882	725	25	0		0	IRX1	5	3600720	Splice_Site	INS	-	TCGA-CN-4739-01A-02D-1512-08	2270317	3600720	177314540	71	9950											
CDH10	1008	broad.mit.edu	37	chr5	24488015	24488015	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaatgaaatcccggacgtcCgtgttatctggagctgtagg	9	12	12	8	3	1	1	0	1	1	0	3	3	3	3	2	3	1	3	2	3	4	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:24488015C>A	uc003jgr.1	-	12	2456	c.2124G>T	c.(2122-2124)ACG>ACT	p.T708T	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	708	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		CCCGGACGTCCGTGTTATCTG	0.473										HNSCC(23;0.051)			41	160					1.59361e-14	1.99038e-14	1	0	A	24488015	A	A	24488015	2	1	50	1	0	0	0	0	0	0	0	1	3111	639	23	3		3	CDH10	5	24488015	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	20887295	24488015	156427245	72	9951											
PDZD2	23037	broad.mit.edu	37	chr5	31983676	31983677	+	Missense_Mutation	DNP	GA	AC	AC																															agcatagaattccaaagacaGatgctcctctgaccacaagc																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:31983676_31983677GA>AC	uc003jhl.2	+	3	1280_1281	c.892_893GA>AC	c.(892-894)GAT>ACT	p.D298T	PDZD2_uc003jhm.2_Missense_Mutation_p.D298T|PDZD2_uc011cnx.1_Missense_Mutation_p.D124T	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	298					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						TCCAAAGACAGATGCTCCTCTG	0.515													36	186					0	0	0	0	AC	31983677	AC	AC	31983676	3	1	50	1	0	0	0	0	1	0	0	0	11755	942	33	2	898	2	PDZD2	5	31983676	Missense_Mutation	DNP	GA	TCGA-CN-4739-01A-02D-1512-08	7495661	31983676	148931584	73	9952											
LIFR	3977	broad.mit.edu	37	chr5	38484967	38484967	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatggcaataattaatcccAcagctgaaacgagagtattg	16	9	9	7	1	0	2	0	1	0	1	1	4	1	2	1	1	2	3	1	1	6	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:38484967A>T	uc010ive.1	-	18	2833	c.2501T>A	c.(2500-2502)GTG>GAG	p.V834E	LIFR_uc003jli.2_Missense_Mutation_p.V834E	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	834	Helical; (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					AATTAATCCCACAGCTGAAAC	0.368			T	PLAG1	salivary adenoma								24	18					0	0	0	0	T	38484967	T	T	38484967	3	4	50	1	0	0	0	0	1	0	0	0	8821	159	6	5	804	5	LIFR	5	38484967	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	6501291	38484967	142430293	74	9953											
C9	735	broad.mit.edu	37	chr5	39341764	39341764	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtcggtgcatcttttcccAttaaattgtccaaagacctc	9	13	7	12	2	1	1	0	0	1	1	5	1	3	1	3	1	1	1	3	1	3	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:39341764A>G	uc003jlv.3	-	3	311	c.222T>C	c.(220-222)AAT>AAC	p.N74N		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	74	TSP type-1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			ATCTTTTCCCATTAAATTGTC	0.443													32	60					0	0	0	0	G	39341764	G	G	39341764	2	3	50	1	0	0	0	0	0	0	0	1	2455	214	8	5		5	C9	5	39341764	Silent	SNP	A	TCGA-CN-4739-01A-02D-1512-08	856797	39341764	141573496	75	9954											
SLCO6A1	133482	broad.mit.edu	37	chr5	101795457	101795457	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccaagtccatagccattcTggactaccattattgactgt	11	12	6	12	0	1	1	0	1	1	0	2	2	2	2	4	1	2	0	4	1	4	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:101795457T>C	uc003knn.2	-	5	1096	c.924A>G	c.(922-924)CCA>CCG	p.P308P	SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Silent_p.P308P|SLCO6A1_uc003knq.2_Silent_p.P246P	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	308	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		ATAGCCATTCTGGACTACCAT	0.353													42	93					0	0	0	0	C	101795457	C	C	101795457	2	2	50	1	0	0	0	0	0	0	0	1	14796	1567	55	5		5	SLCO6A1	5	101795457	Silent	SNP	T	TCGA-CN-4739-01A-02D-1512-08	62453693	101795457	79119803	76	9955											
ADAMTS19	171019	broad.mit.edu	37	chr5	129072905	129072905	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccaaaagctgcagcagaaGagttgacctctagcaggctg	12	6	12	11	0	1	3	0	1	1	2	1	3	1	3	2	1	4	6	2	1	4	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:129072905G>C	uc003kvb.1	+	23	3618	c.3618G>C	c.(3616-3618)AAG>AAC	p.K1206N	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1206					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TGCAGCAGAAGAGTTGACCTC	0.448													14	18					0	0	0	0	C	129072905	C	C	129072905	3	2	50	1	0	0	0	0	1	0	0	0	264	933	33	2	3708	2	ADAMTS19	5	129072905	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	27277448	129072905	51842355	77	9956											
PCDHB5	26167	broad.mit.edu	37	chr5	140515572	140515572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgttgctacgcataatcgcGgagatggcagaaaataccca	14	8	10	9	3	0	2	0	0	0	2	1	3	0	2	1	2	3	4	1	2	5	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:140515572G>A	uc003liq.2	+	1	773	c.556G>A	c.(556-558)GGA>AGA	p.G186R		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	186	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCATAATCGCGGAGATGGCAG	0.517													23	66					0	0	0	0	A	140515572	A	A	140515572	3	1	50	1	0	0	0	0	1	0	0	0	11599	1117	39	1	558	1	PCDHB5	5	140515572	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	11442667	140515572	40399688	78	9957											
PPP2R2B	5521	broad.mit.edu	37	chr5	145979965	145979965	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacttcacatccgaaatCgaagagataatttcagagaa	17	9	7	8	2	2	3	2	1	0	2	4	7	3	3	1	0	1	0	1	0	5	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:145979965C>A	uc003loe.2	-	7	1374	c.849G>T	c.(847-849)TCG>TCT	p.S283S	PPP2R2B_uc010jgm.2_Silent_p.S272S|PPP2R2B_uc003log.3_Silent_p.S283S|PPP2R2B_uc003lof.3_Silent_p.S283S|PPP2R2B_uc003loi.3_Silent_p.S286S|PPP2R2B_uc003loh.3_Silent_p.S283S|PPP2R2B_uc003loj.3_Silent_p.S263S|PPP2R2B_uc003lok.3_Silent_p.S272S|PPP2R2B_uc011dbu.1_Silent_p.S289S|PPP2R2B_uc011dbv.1_Silent_p.S341S	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	283	WD 5.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATCCGAAATCGAAGAGATAA	0.428													42	69					3.4345e-17	4.36081e-17	1	0	A	145979965	A	A	145979965	2	1	50	1	0	0	0	0	0	0	0	1	12445	871	31	3		3	PPP2R2B	5	145979965	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	5464393	145979965	34935295	79	9958											
NSD1	64324	broad.mit.edu	37	chr5	176687152	176687152	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcatgttaatgttagctggtGctttgtgtgctcagaaggta	8	15	13	5	0	1	1	1	0	0	1	1	1	1	1	0	2	3	7	0	2	4	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr5:176687152G>C	uc003mfr.3	+	14	5267	c.5129G>C	c.(5128-5130)TGC>TCC	p.C1710S	NSD1_uc003mft.3_Missense_Mutation_p.C1441S|NSD1_uc003mfs.1_Missense_Mutation_p.C1607S|NSD1_uc011dfx.1_Missense_Mutation_p.C1358S	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1710	PHD-type 3.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GTTAGCTGGTGCTTTGTGTGC	0.383			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			15	31					0	0	0	0	C	176687152	C	C	176687152	3	2	50	1	0	0	0	0	1	0	0	0	10723	1319	46	4	5179	4	NSD1	5	176687152	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	30707187	176687152	4228108	80	9959											
JARID2	3720	broad.mit.edu	37	chr6	15512521	15512521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtttgtcgtctgcttccCgggatcctttgtgtccaaag	5	14	10	12	2	1	0	0	0	1	0	5	1	4	1	4	1	1	2	4	1	1	3	rs145282448		TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr6:15512521C>T	uc003nbj.2	+	14	3279	c.3035C>T	c.(3034-3036)CCG>CTG	p.P1012L	JARID2_uc011div.1_Missense_Mutation_p.P840L	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	1012	JmjC.				central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				GTCTGCTTCCCGGGATCCTTT	0.582													6	133					0	0	0	0	T	15512521	T	T	15512521	3	4	50	1	0	0	0	0	1	0	0	0	7984	652	23	1	3089	1	JARID2	6	15512521	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		15512521	155602546	81	9960											
KIAA0319	9856	broad.mit.edu	37	chr6	24596542	24596542	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagggggagcccctgttcagCatcatgtccccatagtccag	8	8	12	13	0	2	0	2	0	0	0	4	2	4	1	5	2	2	2	5	2	1	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr6:24596542C>G	uc011djo.1	-	3	597	c.360G>C	c.(358-360)ATG>ATC	p.M120I	KIAA0319_uc011djp.1_Missense_Mutation_p.M75I|KIAA0319_uc003neh.1_Missense_Mutation_p.M120I|KIAA0319_uc011djq.1_Missense_Mutation_p.M111I|KIAA0319_uc011djr.1_Missense_Mutation_p.M120I	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	120	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CCCTGTTCAGCATCATGTCCC	0.557													71	74					0	0	0	0	G	24596542	G	G	24596542	3	3	50	1	0	0	0	0	1	0	0	0	8207	710	25	4	2934	4	KIAA0319	6	24596542	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	9084021	24596542	146518525	82	9961											
HIST1H1C	3006	broad.mit.edu	37	chr6	26056327	26056327	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggcttccccggaggctgcCttcttgttgagtttaaagga	6	14	12	9	1	1	1	0	1	1	0	2	3	2	3	3	4	1	4	3	4	2	7			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr6:26056327C>A	uc003nfw.2	-	1	373	c.330G>T	c.(328-330)AAG>AAT	p.K110N		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	110					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						CGGAGGCTGCCTTCTTGTTGA	0.567													9	200					1.12685e-05	1.24482e-05	1	0	A	26056327	A	A	26056327	3	1	50	1	0	0	0	0	1	0	0	0	7163	680	24	4	315	4	HIST1H1C	6	26056327	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	1459785	26056327	145058740	83	9962											
HIST1H2BN	8341	broad.mit.edu	37	chr6	27806588	27806588	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggtgctgaagcaggtccAccccgacaccggtatctcgt	9	7	11	14	3	1	1	0	1	1	0	3	2	2	1	4	3	2	3	4	3	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr6:27806588A>G	uc003njv.2	+	1	149	c.149A>G	c.(148-150)CAC>CGC	p.H50R	HIST1H2AK_uc003njs.2_5'Flank|HIST1H2BN_uc003njt.1_RNA|HIST1H2BN_uc003nju.1_Missense_Mutation_p.H50R	NM_003520	NP_003511	Q99877	H2B1N_HUMAN	histone cluster 1, H2bn	50					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AAGCAGGTCCACCCCGACACC	0.597													89	305					0	0	0	0	G	27806588	G	G	27806588	3	3	50	1	0	0	0	0	1	0	0	0	7192	159	6	5	151	5	HIST1H2BN	6	27806588	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	1750261	27806588	143308479	84	9963											
RPS10	6204	broad.mit.edu	37	chr6	34392463	34392463	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tacctttaggccgaggcctgCcagtctctggacggctacgg	6	9	13	13	3	1	0	0	0	1	0	2	2	1	1	4	5	3	1	4	5	3	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr6:34392463C>T	uc003ojm.2	-	3	525	c.305G>A	c.(304-306)GGC>GAC	p.G102D	RPS10_uc003ojn.2_Missense_Mutation_p.G102D	NM_001014	NP_001005	P46783	RS10_HUMAN	ribosomal protein S10	102					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding				0						CCGAGGCCTGCCAGTCTCTGG	0.498													3	52					0	0	0	0	T	34392463	T	T	34392463	3	4	50	1	0	0	0	0	1	0	0	0	13685	739	26	4	208	4	RPS10	6	34392463	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	6585875	34392463	136722604	85	9964											
KIF6	221458	broad.mit.edu	37	chr6	39602685	39602685	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagatcataaccacattcaTtgtagatttccaaataggaa	18	11	5	7	0	2	2	2	0	0	2	3	3	3	3	2	1	1	1	2	1	6	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr6:39602685T>C	uc003oot.2	-	5	544	c.449A>G	c.(448-450)AAT>AGT	p.N150S	KIF6_uc010jxa.1_5'UTR|KIF6_uc011dua.1_Missense_Mutation_p.N150S|KIF6_uc010jxb.1_Missense_Mutation_p.N150S	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	150	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						ACCACATTCATTGTAGATTTC	0.363													45	128					0	0	0	0	C	39602685	C	C	39602685	3	2	50	1	0	0	0	0	1	0	0	0	8347	1493	52	5	2071	5	KIF6	6	39602685	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	5210222	39602685	131512382	86	9965											
MEP1A	4224	broad.mit.edu	37	chr6	46806851	46806851	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttctccatcatcgccatccTttcccaaaggccaaggaagt	10	10	6	15	1	2	0	1	0	1	0	6	1	4	1	5	2	0	0	5	2	3	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr6:46806851T>C	uc010jzh.1	+	14	2261	c.2219T>C	c.(2218-2220)CTT>CCT	p.L740P	MEP1A_uc011dwg.1_Missense_Mutation_p.L462P|MEP1A_uc011dwh.1_Missense_Mutation_p.L768P|MEP1A_uc011dwi.1_Missense_Mutation_p.L640P	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	740	Helical; (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			ATCGCCATCCTTTCCCAAAGG	0.587													41	107					0	0	0	0	C	46806851	C	C	46806851	3	2	50	1	0	0	0	0	1	0	0	0	9528	1609	56	5	2273	5	MEP1A	6	46806851	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	7204166	46806851	124308216	87	9966											
MTO1	25821	broad.mit.edu	37	chr6	74191953	74191953	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctgataatgctgacagccGgctcacactgcgaggtaact	10	8	10	13	2	1	2	1	2	0	0	1	3	1	2	2	2	4	3	2	2	2	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr6:74191953G>T	uc003pgy.3	+	9	1650	c.1526G>T	c.(1525-1527)CGG>CTG	p.R509L	MTO1_uc010kav.2_Missense_Mutation_p.R524L|MTO1_uc003pgz.3_Missense_Mutation_p.R484L|MTO1_uc003pha.3_Missense_Mutation_p.R146L|MTO1_uc003phb.3_Missense_Mutation_p.R435L	NM_133645	NP_598400	Q9Y2Z2	MTO1_HUMAN	mitochondrial translation optimization 1 homolog	509					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			ovary(3)|skin(2)|pancreas(1)	6						GCTGACAGCCGGCTCACACTG	0.373													18	64					1.45105e-14	1.81976e-14	1	0	T	74191953	T	T	74191953	3	4	50	1	0	0	0	0	1	0	0	0	10006	1116	39	3	1684	3	MTO1	6	74191953	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	27385102	74191953	96923114	88	9967											
HACE1	57531	broad.mit.edu	37	chr6	105243517	105243517	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttagaatctttaggtacTggctttcactttgctgagac	8	17	9	7	0	2	2	1	1	1	2	2	3	2	2	0	2	2	4	0	2	4	7			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr6:105243517T>C	uc003pqu.1	-	10	1137	c.860A>G	c.(859-861)CAG>CGG	p.Q287R	HACE1_uc010kcy.1_5'UTR|HACE1_uc010kcz.1_Missense_Mutation_p.Q287R	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	287					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		CTTTAGGTACTGGCTTTCACT	0.338													22	102					0	0	0	0	C	105243517	C	C	105243517	3	2	50	1	0	0	0	0	1	0	0	0	6979	1580	55	5	1929	5	HACE1	6	105243517	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	31051564	105243517	65871550	89	9968											
VNN1	8876	broad.mit.edu	37	chr6	133014422	133014422	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcaggctccttgggtacAttgaattgattttcacccat	9	15	7	10	0	2	2	2	2	1	0	4	2	3	2	2	2	1	2	2	2	2	6	rs141622053	byFrequency	TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr6:133014422A>T	uc003qdo.2	-	4	587	c.567T>A	c.(565-567)AAT>AAA	p.N189K		NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	189	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		CCTTGGGTACATTGAATTGAT	0.373													17	74					0	0	0	0	T	133014422	T	T	133014422	3	4	50	1	0	0	0	0	1	0	0	0	17250	214	8	5	990	5	VNN1	6	133014422	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	27770905	133014422	38100645	90	9969											
LFNG	3955	broad.mit.edu	37	chr7	2559807	2559807	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccgccgacggccacccgcgCcccctggccgagccgctcgc	3	2	12	24	8	0	0	0	0	0	0	1	2	0	0	8	2	1	1	8	2	0	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:2559807C>T	uc003smf.2	+	1	329	c.312C>T	c.(310-312)CGC>CGT	p.R104R	LFNG_uc003smg.2_Silent_p.R104R	NM_001040167	NP_001035257	Q8NES3	LFNG_HUMAN	lunatic fringe isoform a	104	Lumenal (Potential).			R -> A (in Ref. 3; AAF07187).	organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		gccacccgcgccccctggccg	0.373													7	7					0	0	0	0	T	2559807	T	T	2559807	2	4	50	1	0	0	0	0	0	0	0	1	8777	726	26	4		4	LFNG	7	2559807	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08		2559807	156578856	91	9970											
NPSR1	387129	broad.mit.edu	37	chr7	34724268	34724268	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaagaagtcaagaatgacCttctttgtgactcagctggc	13	10	10	8	0	3	5	2	2	1	3	3	5	3	5	1	1	1	1	1	1	5	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:34724268C>T	uc003teg.1	+	2	380	c.252C>T	c.(250-252)ACC>ACT	p.T84T	AAA1_uc010kwo.1_Intron|AAA1_uc010kwp.1_Intron|AAA1_uc003tdz.2_Intron|AAA1_uc010kwq.1_Intron|AAA1_uc003teb.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Silent_p.T84T|NPSR1_uc010kwt.1_5'UTR|NPSR1_uc010kwu.1_5'UTR|NPSR1_uc010kwv.1_Silent_p.T84T|NPSR1_uc003tei.1_Silent_p.T84T|NPSR1_uc010kww.1_Silent_p.T84T|NPSR1_uc011kar.1_Silent_p.T84T	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	84	Helical; Name=2; (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	CAAGAATGACCTTCTTTGTGA	0.418													38	125					0	0	0	0	T	34724268	T	T	34724268	2	4	50	1	0	0	0	0	0	0	0	1	10654	668	24	4		4	NPSR1	7	34724268	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	32164461	34724268	124414395	92	9971											
ELMO1	9844	broad.mit.edu	37	chr7	37298793	37298793	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaagacgcttactcagtgcCgctctccaccatctgcgtga	10	9	8	14	3	3	2	1	1	2	1	4	2	3	2	3	0	3	2	3	0	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:37298793C>A	uc003tfk.1	-	6	713	c.406G>T	c.(406-408)GGC>TGC	p.G136C	ELMO1_uc011kbc.1_Missense_Mutation_p.G40C|ELMO1_uc010kxg.1_Missense_Mutation_p.G136C	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	136					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						TACTCAGTGCCGCTCTCCACC	0.502													12	33					0.000978159	0.00102858	1	0	A	37298793	A	A	37298793	3	1	50	1	0	0	0	0	1	0	0	0	5089	652	23	3	1845	3	ELMO1	7	37298793	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	2574525	37298793	121839870	93	9972											
GPR141	353345	broad.mit.edu	37	chr7	37780085	37780085	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttcatagtgcttattggCgggctggtgggtgtcatttc	5	16	13	7	1	2	0	2	0	0	0	3	0	2	0	0	4	2	2	0	4	3	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:37780085C>T	uc003tfm.1	+	1	90	c.90C>T	c.(88-90)GGC>GGT	p.G30G	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	30	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						TGCTTATTGGCGGGCTGGTGG	0.507													54	142					0	0	0	0	T	37780085	T	T	37780085	2	4	50	1	0	0	0	0	0	0	0	1	6687	755	27	1		1	GPR141	7	37780085	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	481292	37780085	121358578	94	9973											
TARP	445347	broad.mit.edu	37	chr7	38313237	38313237	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aataccttgatttttttgccCaactcttgcccaccacctga	9	14	4	14	0	1	2	0	2	1	0	1	2	1	2	5	0	4	0	5	0	3	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:38313237C>A	uc003tge.1	-	4	755	c.378G>T	c.(376-378)TTG>TTT	p.L126F	uc003tfz.1_Intron|TARP_uc003tgb.2_5'UTR|TARP_uc003tgc.1_5'UTR|TARP_uc003tgd.1_Intron|TARP_uc010kxi.1_Intron|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						TTTTTTTGCCCAACTCTTGCC	0.269													56	214					3.07184e-27	4.05165e-27	1	0	A	38313237	A	A	38313237	3	1	50	1	0	0	0	0	1	0	0	0	15624	609	21	4		4	TARP	7	38313237	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	533152	38313237	120825426	95	9974											
ABCA13	154664	broad.mit.edu	37	chr7	48390265	48390265	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgctggatgagatgtttaaCcatgcaggcgctggacgctt	8	11	13	9	2	0	1	0	1	0	1	0	4	0	3	1	3	3	5	1	3	1	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:48390265C>A	uc003toq.2	+	30	10255	c.10230C>A	c.(10228-10230)AAC>AAA	p.N3410K	ABCA13_uc010kys.1_Missense_Mutation_p.N484K|ABCA13_uc003tos.1_Missense_Mutation_p.N236K	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3410					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AGATGTTTAACCATGCAGGCG	0.512													47	217					6.08268e-21	7.88686e-21	1	0	A	48390265	A	A	48390265	3	1	50	1	0	0	0	0	1	0	0	0	31	506	18	4	10177	4	ABCA13	7	48390265	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	10077028	48390265	110748398	96	9975											
NSUN5	55695	broad.mit.edu	37	chr7	72722501	72722501	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgatcacagcatccagcacgGcggagtagcgctgcgtttcg	8	7	13	13	6	1	0	1	0	0	0	3	2	2	1	1	2	4	5	1	2	1	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:72722501G>C	uc003txw.2	-	2	179	c.143C>G	c.(142-144)GCC>GGC	p.A48G	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Missense_Mutation_p.A48G|NSUN5_uc003txx.2_Missense_Mutation_p.A48G|NSUN5_uc011kev.1_Missense_Mutation_p.A48G	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	48							methyltransferase activity				0		Lung NSC(55;0.163)				ATCCAGCACGGCGGAGTAGCG	0.687													23	78					0	0	0	0	C	72722501	C	C	72722501	3	2	50	1	0	0	0	0	1	0	0	0	10735	1203	42	4	1314	4	NSUN5	7	72722501	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	24332236	72722501	86416162	97	9976											
CDK14	5218	broad.mit.edu	37	chr7	90419941	90419941	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caggctgcaggaagaagaagGgacacctttcacagctatca	14	6	11	10	0	2	2	2	0	0	2	2	4	2	4	1	3	2	3	1	3	4	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:90419941G>T	uc003uky.2	+	5	740	c.518G>T	c.(517-519)GGG>GTG	p.G173V	CDK14_uc003ukt.1_Missense_Mutation_p.G127V|CDK14_uc003ukv.1_Missense_Mutation_p.G127V|CDK14_uc003uku.1_Missense_Mutation_p.G127V|CDK14_uc003ukx.1_RNA|CDK14_uc003ukz.1_Missense_Mutation_p.G155V|CDK14_uc010les.1_Missense_Mutation_p.G127V|CDK14_uc011khl.1_Missense_Mutation_p.G44V	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	173	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						GAAGAAGAAGGGACACCTTTC	0.403													21	87					1.9806e-07	2.24468e-07	1	0	T	90419941	T	T	90419941	3	4	50	1	0	0	0	0	1	0	0	0	3145	1232	43	4	478	4	CDK14	7	90419941	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	17697440	90419941	68718722	98	9977											
AKAP9	10142	broad.mit.edu	37	chr7	91709455	91709455	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagaagccctcaagatgttGaagttctcaaggttagtttt	13	13	9	6	0	2	3	2	1	1	2	3	3	2	3	1	1	1	4	1	1	6	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:91709455G>C	uc003ulg.2	+	31	8233	c.8008G>C	c.(8008-8010)GAA>CAA	p.E2670Q	AKAP9_uc003ulf.2_Missense_Mutation_p.E2662Q|AKAP9_uc003uli.2_Missense_Mutation_p.E2293Q|AKAP9_uc003ulj.2_Missense_Mutation_p.E440Q	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2682	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCAAGATGTTGAAGTTCTCAA	0.323			T	BRAF	papillary thyroid								8	32					0	0	0	0	C	91709455	C	C	91709455	3	2	50	1	0	0	0	0	1	0	0	0	459	1291	45	2	8130	2	AKAP9	7	91709455	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	1289514	91709455	67429208	99	9978											
PDK4	5166	broad.mit.edu	37	chr7	95222138	95222138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgatccaagaaatattgaaGattttgattggtgactgggt	12	14	11	4	1	0	5	0	3	0	2	2	6	1	5	1	2	0	0	1	2	4	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:95222138G>A	uc003uoa.2	-	4	783	c.463C>T	c.(463-465)CTT>TTT	p.L155F	PDK4_uc003unz.2_5'Flank	NM_002612	NP_002603	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase 4 precursor	155	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity				0	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			AAATATTGAAGATTTTGATTG	0.383													41	146					0	0	0	0	A	95222138	A	A	95222138	3	1	50	1	0	0	0	0	1	0	0	0	11732	942	33	2	804	2	PDK4	7	95222138	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	3512683	95222138	63916525	100	9979											
GAL3ST4	79690	broad.mit.edu	37	chr7	99764268	99764268	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgggcagggagggcgaagcGcagcccgtgctggtccccat	6	4	18	13	4	0	0	0	0	0	0	1	2	1	1	3	4	3	3	3	4	1	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:99764268G>A	uc003utt.2	-	2	1303	c.286C>T	c.(286-288)CGC>TGC	p.R96C	GAL3ST4_uc003utu.2_Missense_Mutation_p.R96C|GAL3ST4_uc010lgq.2_Intron	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	96	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGGGCGAAGCGCAGCCCGTGC	0.637													27	196					0	0	0	0	A	99764268	A	A	99764268	3	1	50	1	0	0	0	0	1	0	0	0	6235	1087	38	1	1182	1	GAL3ST4	7	99764268	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	4542130	99764268	59374395	101	9980											
THAP5	168451	broad.mit.edu	37	chr7	108205353	108205353	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acatgttattttgtatacttCctgttttgggagctggtggc	6	18	11	6	0	0	0	0	0	0	0	1	1	1	1	1	3	2	4	1	3	3	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:108205353C>T	uc003vfm.2	-	3	624	c.470G>A	c.(469-471)GGA>GAA	p.G157E	THAP5_uc003vfl.2_Missense_Mutation_p.G115E	NM_001130475	NP_001123947	Q7Z6K1	THAP5_HUMAN	THAP domain containing 5 isoform 1	157					cell cycle|negative regulation of cell cycle	nucleus	DNA binding|metal ion binding|protease binding				0						TTGTATACTTCCTGTTTTGGG	0.358													7	25					0	0	0	0	T	108205353	T	T	108205353	3	4	50	1	0	0	0	0	1	0	0	0	15913	855	30	2	721	2	THAP5	7	108205353	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	8441085	108205353	50933310	102	9981											
GRM8	2918	broad.mit.edu	37	chr7	126173263	126173263	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagtgtccgctgctctccatAgtcaatgatgatgtgggggg	7	12	14	8	1	2	2	1	2	1	0	4	2	3	2	2	3	1	2	2	3	3	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:126173263A>T	uc003vlr.2	-	8	2484	c.2173T>A	c.(2173-2175)TAT>AAT	p.Y725N	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.Y725N|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	725	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TGCTCTCCATAGTCAATGATG	0.502										HNSCC(24;0.065)			20	45					0	0	0	0	T	126173263	T	T	126173263	3	4	50	1	0	0	0	0	1	0	0	0	6842	420	15	5	615	5	GRM8	7	126173263	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	17967910	126173263	32965400	103	9982											
ADCK2	90956	broad.mit.edu	37	chr7	140380909	140380909	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttgaaaaggaagattgcacGgctggggatcaacatgctcc	12	8	12	9	1	1	2	1	1	0	1	2	4	2	4	1	4	3	3	1	4	4	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr7:140380909G>C	uc003vvy.1	+	4	1455	c.1277G>C	c.(1276-1278)CGG>CCG	p.R426P	ADCK2_uc003vvz.2_Missense_Mutation_p.R426P	NM_052853	NP_443085	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	426	Protein kinase.					integral to membrane	ATP binding|protein serine/threonine kinase activity				0	Melanoma(164;0.00956)					AAGATTGCACGGCTGGGGATC	0.562													18	49					0	0	0	0	C	140380909	C	C	140380909	3	2	50	1	0	0	0	0	1	0	0	0	289	1116	39	3	1291	3	ADCK2	7	140380909	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	14207646	140380909	18757754	104	9983											
CSMD1	64478	broad.mit.edu	37	chr8	3059159	3059159	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagaccccgagagtgagctGagaagtctggcctgtgcatg	9	8	15	9	1	1	4	0	3	1	3	1	7	1	4	3	1	2	2	3	1	1	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:3059159G>A	uc011kwk.1	-	32	5466	c.5076C>T	c.(5074-5076)CTC>CTT	p.L1692L	CSMD1_uc011kwj.1_Silent_p.L1084L|CSMD1_uc003wqe.2_Silent_p.L848L	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1692	Extracellular (Potential).|CUB 10.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGAGTGAGCTGAGAAGTCTGG	0.408													3	19					0	0	0	0	A	3059159	A	A	3059159	2	1	50	1	0	0	0	0	0	0	0	1	3961	1277	45	2		2	CSMD1	8	3059159	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08		3059159	143304863	105	9984											
RP1L1	94137	broad.mit.edu	37	chr8	10468035	10468035	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggatgtgggcgtgaagttCtccgtcatggcatgggaccc	7	9	16	9	2	2	1	1	1	1	0	3	4	2	3	2	4	0	2	2	4	1	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:10468035C>G	uc003wtc.2	-	4	3802	c.3573G>C	c.(3571-3573)GAG>GAC	p.E1191D		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1191					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GCGTGAAGTTCTCCGTCATGG	0.627													24	36					0	0	0	0	G	10468035	G	G	10468035	3	3	50	1	0	0	0	0	1	0	0	0	13598	912	32	2	3633	2	RP1L1	8	10468035	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	7408876	10468035	135895987	106	9985											
WRN	7486	broad.mit.edu	37	chr8	30949360	30949360	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatagaatgtccaacatccCagcttgcttccttggatcag	10	13	7	11	0	1	1	1	0	0	1	4	2	4	2	3	1	3	2	3	1	4	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:30949360C>T	uc003xio.3	+	16	2632	c.1844C>T	c.(1843-1845)CCA>CTA	p.P615L	WRN_uc010lvk.2_Missense_Mutation_p.P82L	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	615	Helicase ATP-binding.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TCCAACATCCCAGCTTGCTTC	0.264			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				15	104					0	0	0	0	T	30949360	T	T	30949360	3	4	50	1	0	0	0	0	1	0	0	0	17470	594	21	4	1902	4	WRN	8	30949360	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	20481325	30949360	115414662	107	9986											
EIF4EBP1	1978	broad.mit.edu	37	chr8	37914778	37914778	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagaagataagcgggcgggcGgtgagtgtcggggcttggcc	7	6	20	8	4	0	3	0	1	0	2	1	3	0	3	1	6	1	1	1	6	2	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:37914778G>T	uc003xks.2	+	2	397	c.325G>T	c.(325-327)GGT>TGT	p.G109C		NM_004095	NP_004086	Q13541	4EBP1_HUMAN	eukaryotic translation initiation factor 4E	109					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|positive regulation of mitotic cell cycle|TOR signaling cascade|translation	cytosol					0	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)				GCGGGCGGGCGGTGAGTGTCG	0.622													25	106					2.79863e-10	3.34524e-10	1	0	T	37914778	T	T	37914778	3	4	50	1	0	0	0	0	1	0	0	0	5056	1130	39	3	331	3	EIF4EBP1	8	37914778	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	6965418	37914778	108449244	108	9987											
ANK1	286	broad.mit.edu	37	chr8	41530294	41530294	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagacatctccagcatggtGtcatgctccgtggccgccaa	8	9	10	14	2	3	1	2	0	1	1	5	1	4	1	4	2	2	2	4	2	1	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:41530294G>A	uc003xok.2	-	38	4758	c.4674C>T	c.(4672-4674)GAC>GAT	p.D1558D	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Intron|ANK1_uc003xoi.2_Silent_p.D1558D|ANK1_uc003xoj.2_Silent_p.D1558D|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Silent_p.D1599D	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1558	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCAGCATGGTGTCATGCTCCG	0.612													9	77					0	0	0	0	A	41530294	A	A	41530294	2	1	50	1	0	0	0	0	0	0	0	1	620	1368	48	4		4	ANK1	8	41530294	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	3615516	41530294	104833728	109	9988											
PRKDC	5591	broad.mit.edu	37	chr8	48761806	48761807	+	Frame_Shift_Del	DEL	AG	-	-																															acaaagtaccacctccagacAgagtgttttcaacactccat																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:48761806_48761807delAG	uc003xqi.2	-	55	7245_7246	c.7188_7189delCT	c.(7186-7191)CTCTGTfs	p.L2396fs	PRKDC_uc003xqj.2_Frame_Shift_Del_p.L2396fs|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2396_2397					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACCTCCAGACAGAGTGTTTTCA	0.495								NHEJ					---	---	---								-	48761807	-	-	48761806	7	5	50	1	0	1	0	1	0	0	0	0	12583	188	7	0	5329	0	PRKDC	8	48761806	Frame_Shift_Del	DEL	AG	TCGA-CN-4739-01A-02D-1512-08	7231512	48761806	97602216	110	9989											
PXDNL	137902	broad.mit.edu	37	chr8	52321119	52321119	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctagtgccagggtcccccAggaccttaggcagccagtgg	7	7	13	14	0	0	0	0	0	0	0	2	1	2	1	6	4	2	1	6	4	2	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:52321119A>C	uc003xqu.3	-	17	3166	c.3065T>G	c.(3064-3066)CTG>CGG	p.L1022R	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1022					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AGGGTCCCCCAGGACCTTAGG	0.562													6	17					0	0	0	0	C	52321119	C	C	52321119	3	2	50	1	0	0	0	0	1	0	0	0	12913	188	7	5	1354	5	PXDNL	8	52321119	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	3559313	52321119	94042903	111	9990											
ST18	9705	broad.mit.edu	37	chr8	53085133	53085133	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcatccataggttttatCatgatttcctctatggaaaa	11	17	5	8	0	3	1	2	1	1	0	5	2	5	2	2	2	0	1	2	2	5	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:53085133C>A	uc003xqz.2	-	5	444	c.288G>T	c.(286-288)ATG>ATT	p.M96I	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.M61I|ST18_uc011lds.1_Missense_Mutation_p.M1I|ST18_uc003xra.2_Missense_Mutation_p.M96I|ST18_uc003xrb.2_Missense_Mutation_p.M96I	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	96						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TAGGTTTTATCATGATTTCCT	0.299													29	67					1.88708e-17	2.40603e-17	1	0	A	53085133	A	A	53085133	3	1	50	1	0	0	0	0	1	0	0	0	15278	826	29	2	2923	2	ST18	8	53085133	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	764014	53085133	93278889	112	9991											
RP1	6101	broad.mit.edu	37	chr8	55540810	55540810	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaataaccaacagcatgacAtcaagtgaaagaaacatttc	19	8	5	9	0	2	3	2	2	0	1	3	3	2	3	1	0	4	1	1	0	6	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:55540810A>G	uc003xsd.1	+	4	4516	c.4368A>G	c.(4366-4368)ACA>ACG	p.T1456T	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1456					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACAGCATGACATCAAGTGAAA	0.373													35	114					0	0	0	0	G	55540810	G	G	55540810	2	3	50	1	0	0	0	0	0	0	0	1	13597	204	8	5		5	RP1	8	55540810	Silent	SNP	A	TCGA-CN-4739-01A-02D-1512-08	2455677	55540810	90823212	113	9992											
IMPAD1	54928	broad.mit.edu	37	chr8	57890701	57890701	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtgacgtactttcgaagaTcctctatgagaaaaaaaaca	17	10	7	7	2	1	3	0	2	1	2	3	5	2	3	1	0	2	1	1	0	8	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:57890701T>G	uc003xte.3	-	3	837	c.554A>C	c.(553-555)GAT>GCT	p.D185A		NM_017813	NP_060283	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	185						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			ovary(1)	1		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				CTTTCGAAGATCCTCTATGAG	0.313													12	349					0	0	0	0	G	57890701	G	G	57890701	3	3	50	1	0	0	0	0	1	0	0	0	7764	1435	50	5	537	5	IMPAD1	8	57890701	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	2349891	57890701	88473321	114	9993											
NKAIN3	286183	broad.mit.edu	37	chr8	63492237	63492237	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctcgatacataatggtggTaagtcttatttttatcattt	11	18	6	6	1	2	0	1	0	1	0	3	1	2	0	1	2	1	1	1	2	5	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:63492237T>C	uc010lyq.1	+	2	324	c.192_splice	c.e2+2	p.V64_splice		NM_173688	NP_775959	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3							integral to membrane|plasma membrane					0	Breast(64;0.127)	Lung NSC(129;0.187)				ATAATGGTGGTAAGTCTTATT	0.323													29	75					0	0	0	0	C	63492237	C	C	63492237	5	2	50	1	0	0	0	0	0	0	1	0	10491	1652	57	5	200	5	NKAIN3	8	63492237	Splice_Site	SNP	T	TCGA-CN-4739-01A-02D-1512-08	5601536	63492237	82871785	115	9994											
PI15	51050	broad.mit.edu	37	chr8	75756223	75756223	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcccctacaggtttgggAtgaaaatcttgcaaaatcgg	11	13	9	8	1	1	1	0	1	1	0	3	2	2	2	2	3	2	2	2	3	5	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:75756223A>G	uc003yal.2	+	3	460	c.281A>G	c.(280-282)GAT>GGT	p.D94G	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.D94G	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	94						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			CAGGTTTGGGATGAAAATCTT	0.393													46	186					0	0	0	0	G	75756223	G	G	75756223	3	3	50	1	0	0	0	0	1	0	0	0	11923	333	12	5	287	5	PI15	8	75756223	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	12263986	75756223	70607799	116	9995											
PGCP	10404	broad.mit.edu	37	chr8	97797214	97797214	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgcaagaatggcatctctaAgaggacttttgaagaaataa	17	10	9	5	0	1	4	0	1	1	3	2	5	1	5	0	2	1	2	0	2	6	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:97797214A>T	uc003yhw.2	+	2	255	c.89A>T	c.(88-90)AAG>ATG	p.K30M	PGCP_uc010mbe.2_Missense_Mutation_p.K30M	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	30					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					GGCATCTCTAAGAGGACTTTT	0.393													78	191					0	0	0	0	T	97797214	T	T	97797214	3	4	50	1	0	0	0	0	1	0	0	0	11841	72	3	5	91	5	PGCP	8	97797214	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	22040991	97797214	48566808	117	9996											
PKHD1L1	93035	broad.mit.edu	37	chr8	110412536	110412536	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caagggtgatgaccgttatgCtatttattttagccagactg	10	14	10	7	1	0	3	0	2	0	1	0	3	0	3	2	1	2	2	2	1	5	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:110412536C>A	uc003yne.2	+	13	1348	c.1244C>A	c.(1243-1245)GCT>GAT	p.A415D		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	415	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GACCGTTATGCTATTTATTTT	0.368										HNSCC(38;0.096)			16	263					2.32078e-09	2.71053e-09	1	0	A	110412536	A	A	110412536	3	1	50	1	0	0	0	0	1	0	0	0	12027	797	28	4	1294	4	PKHD1L1	8	110412536	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	12615322	110412536	35951486	118	9997											
CSMD3	114788	broad.mit.edu	37	chr8	113395804	113395804	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcttatttacctgaatagCttccaagtcttggagcattg	9	16	7	9	0	2	1	0	1	2	0	4	2	3	2	2	1	3	2	2	1	5	7			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr8:113395804C>A	uc003ynu.2	-	37	6182	c.6023G>T	c.(6022-6024)AGC>ATC	p.S2008I	CSMD3_uc003yns.2_Missense_Mutation_p.S1210I|CSMD3_uc003ynt.2_Missense_Mutation_p.S1968I|CSMD3_uc011lhx.1_Missense_Mutation_p.S1904I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2008	Extracellular (Potential).|CUB 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACCTGAATAGCTTCCAAGTCT	0.333										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	129					1.00905e-13	1.25007e-13	1	0	A	113395804	A	A	113395804	3	1	50	1	0	0	0	0	1	0	0	0	3963	797	28	4	5240	4	CSMD3	8	113395804	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	2983268	113395804	32968218	119	9998											
KCNV2	169522	broad.mit.edu	37	chr9	2718222	2718222	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccggccgtcttccagctggtCtacaatttctacctgtccgg	5	12	9	15	3	3	0	0	0	3	0	5	0	5	0	5	3	3	1	5	3	3	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr9:2718222C>G	uc003zho.1	+	1	697	c.483C>G	c.(481-483)GTC>GTG	p.V161V		NM_133497	NP_598004	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	161	Helical; Name=Segment S1; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(50;0.0257)		TCCAGCTGGTCTACAATTTCT	0.642													6	29					0	0	0	0	G	2718222	G	G	2718222	2	3	50	1	0	0	0	0	0	0	0	1	8134	900	32	2		2	KCNV2	9	2718222	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08		2718222	138495209	120	9999											
IFNA16	3449	broad.mit.edu	37	chr9	21216750	21216750	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agttttcaatccttccttctTaatcctttttgcaagtttgt	7	21	4	9	0	2	0	1	0	1	0	5	0	5	0	3	0	1	3	3	0	3	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr9:21216750T>A	uc003zor.1	-	1	561	c.555A>T	c.(553-555)TTA>TTT	p.L185F	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	interferon, alpha 16 precursor	185					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			skin(1)	1				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		CCTTCCTTCTTAATCCTTTTT	0.373													99	253					0	0	0	0	A	21216750	A	A	21216750	3	1	50	1	0	0	0	0	1	0	0	0	7574	1751	61	5	18	5	IFNA16	9	21216750	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	18498528	21216750	119996681	121	10000											
PCSK5	5125	broad.mit.edu	37	chr9	78749092	78749092	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccgtgcgggacatttgaacGctaatgactggaaaaccaat	13	8	10	10	3	0	2	0	2	0	0	0	4	0	4	2	2	3	1	2	2	5	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr9:78749092G>A	uc004ajz.2	+	10	1814	c.1276G>A	c.(1276-1278)GCT>ACT	p.A426T	PCSK5_uc004ajy.2_Missense_Mutation_p.A426T|PCSK5_uc004aka.2_Intron	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	426	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						ACATTTGAACGCTAATGACTG	0.418													6	140					0	0	0	0	A	78749092	A	A	78749092	3	1	50	1	0	0	0	0	1	0	0	0	11657	1087	38	1	1314	1	PCSK5	9	78749092	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	57532342	78749092	62464339	122	10001											
OR2K2	26248	broad.mit.edu	37	chr9	114090596	114090596	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aataagagtgctgttgcccaAgagcgttgtcagatacatta	13	11	10	7	1	1	3	1	0	0	3	1	3	1	3	1	0	4	3	1	0	5	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr9:114090596A>T	uc011lwp.1	-	1	118	c.118T>A	c.(118-120)TTG>ATG	p.L40M		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	69	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTGTTGCCCAAGAGCGTTGTC	0.413													46	95					0	0	0	0	T	114090596	T	T	114090596	3	4	50	1	0	0	0	0	1	0	0	0	11059	69	3	5	835	5	OR2K2	9	114090596	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	35341504	114090596	27122835	123	10002											
OR1B1	347169	broad.mit.edu	37	chr9	125391138	125391138	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagaatagcggccccaattCggacataagagagtacaatg	15	7	11	8	2	0	2	0	0	0	2	1	4	0	3	2	2	2	2	2	2	7	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr9:125391138C>A	uc011lyz.1	-	1	677	c.677G>T	c.(676-678)CGA>CTA	p.R226L		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCCCCAATTCGGACATAAGA	0.542													19	64					2.94398e-08	3.39947e-08	1	0	A	125391138	A	A	125391138	3	1	50	1	0	0	0	0	1	0	0	0	11005	884	31	3	282	3	OR1B1	9	125391138	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	11300542	125391138	15822293	124	10003											
GPR21	2844	broad.mit.edu	37	chr9	125797359	125797359	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttccactggggcaaacctGgatatcatggagatgtgttt	9	14	11	7	0	1	1	1	0	0	1	2	3	2	2	2	4	1	2	2	4	2	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr9:125797359G>T	uc011lzk.1	+	1	514	c.514G>T	c.(514-516)GGA>TGA	p.G172*	RABGAP1_uc004bnl.3_Intron|RABGAP1_uc011lzh.1_Intron|RABGAP1_uc011lzj.1_Intron|GPR21_uc011lzi.1_RNA	NM_005294	NP_005285	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	172	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1						GGGCAAACCTGGATATCATGG	0.512													43	224					5.44703e-19	7.00332e-19	1	0	T	125797359	T	T	125797359	4	4	50	1	0	0	0	0	0	1	0	0	6719	1349	47	4	516	4	GPR21	9	125797359	Nonsense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	406221	125797359	15416072	125	10004											
NEK6	10783	broad.mit.edu	37	chr9	127089616	127089616	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccttctcctcgccctgcaGacatcaagcctgccaacgtg	7	9	7	18	2	2	1	1	0	1	1	5	1	3	1	5	0	4	1	5	0	2	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr9:127089616G>A	uc004bog.2	+	7	664	c.515_splice	c.e7-1	p.D172_splice	NEK6_uc004bof.2_Splice_Site_p.D190_splice|NEK6_uc004boh.2_Splice_Site_p.D206_splice|NEK6_uc010mwj.2_Splice_Site_p.D125_splice|NEK6_uc010mwk.2_Splice_Site_p.D172_splice|NEK6_uc004boi.2_Splice_Site_p.D172_splice	NM_014397	NP_055212	Q9HC98	NEK6_HUMAN	NIMA-related kinase 6 isoform 2						apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|kidney(1)	3						TCGCCCTGCAGACATCAAGCC	0.632													100	233					0	0	0	0	A	127089616	A	A	127089616	5	1	50	1	0	0	0	0	0	0	1	0	10382	956	33	2	721	2	NEK6	9	127089616	Splice_Site	SNP	G	TCGA-CN-4739-01A-02D-1512-08	1292257	127089616	14123815	126	10005											
UCK1	83549	broad.mit.edu	37	chr9	134404388	134404388	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggtgtactgcgtcagaatCtgctccaggtccctccctcg	5	11	11	14	2	2	1	1	0	1	1	6	1	5	1	3	2	3	2	3	2	2	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr9:134404388C>G	uc004cay.2	-	5	647	c.546G>C	c.(544-546)CAG>CAC	p.Q182H	UCK1_uc010mzk.2_Missense_Mutation_p.Q173H|UCK1_uc004cba.2_Intron|UCK1_uc004caz.2_RNA	NM_031432	NP_113620	Q9HA47	UCK1_HUMAN	uridine-cytidine kinase 1 isoform a	182					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;2.34e-05)|Epithelial(140;0.000219)		GCGTCAGAATCTGCTCCAGGT	0.642													11	20					0	0	0	0	G	134404388	G	G	134404388	3	3	50	1	0	0	0	0	1	0	0	0	16991	912	32	2	299	2	UCK1	9	134404388	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	7314772	134404388	6809043	127	10006											
KIAA0649	9858	broad.mit.edu	37	chr9	138377302	138377302	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacaaccacgcaggagaacGagggcagcacgaagccggca	14	1	13	13	4	1	1	1	0	0	1	1	4	1	1	2	3	4	4	2	3	3	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr9:138377302G>T	uc004cfr.1	+	4	1495	c.946G>T	c.(946-948)GAG>TAG	p.E316*		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	316						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		GCAGGAGAACGAGGGCAGCAC	0.602													21	124					1.2644e-06	1.40709e-06	1	0	T	138377302	T	T	138377302	4	4	50	1	0	0	0	0	0	1	0	0	8226	1059	37	3	948	3	KIAA0649	9	138377302	Nonsense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	3972914	138377302	2836129	128	10007											
SVIL	6840	broad.mit.edu	37	chr10	29822126	29822126	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgatgctacccagctacaCtcagatgcattttctggggt	8	12	10	11	0	2	2	1	1	1	1	2	2	2	2	1	2	5	4	1	2	2	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr10:29822126C>A	uc001iut.1	-	8	1923	c.1170G>T	c.(1168-1170)GAG>GAT	p.E390D	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_Missense_Mutation_p.E390D	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	390					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CCCAGCTACACTCAGATGCAT	0.562													32	87					2.20262e-25	2.88035e-25	1	0	A	29822126	A	A	29822126	3	1	50	1	0	0	0	0	1	0	0	0	15487	564	20	4	5598	4	SVIL	10	29822126	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		29822126	105712621	129	10008											
KIAA1274	27143	broad.mit.edu	37	chr10	72285834	72285834	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actccttccagagcactagcTtgcataacagcaaggccaag	13	7	8	13	0	0	1	0	0	0	1	2	1	2	1	3	1	5	4	3	1	4	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr10:72285834T>A	uc001jrd.3	+	2	408	c.127T>A	c.(127-129)TTG>ATG	p.L43M		NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	43										ovary(2)|central_nervous_system(1)	3						GAGCACTAGCTTGCATAACAG	0.602													24	86					0	0	0	0	A	72285834	A	A	72285834	3	1	50	1	0	0	0	0	1	0	0	0	8259	1606	56	5	129	5	KIAA1274	10	72285834	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	42463708	72285834	63248913	130	10009											
GRID1	2894	broad.mit.edu	37	chr10	87482888	87482888	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atggccatggagttcacggaAgattcgccacctgcgggagg	9	7	15	10	3	1	1	1	0	0	1	2	4	1	4	3	5	1	1	3	5	1	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr10:87482888A>G	uc001kdl.1	-	12	1970	c.1869T>C	c.(1867-1869)TCT>TCC	p.S623S	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Silent_p.S194S	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	623	Cytoplasmic (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGTTCACGGAAGATTCGCCAC	0.597										Multiple Myeloma(13;0.14)			13	50					0	0	0	0	G	87482888	G	G	87482888	2	3	50	1	0	0	0	0	0	0	0	1	6810	59	3	5		5	GRID1	10	87482888	Silent	SNP	A	TCGA-CN-4739-01A-02D-1512-08	15197054	87482888	48051859	131	10010											
RNLS	55328	broad.mit.edu	37	chr10	90122454	90122454	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggagtagctcacagcctcCagttgctgcctttggcattc	7	11	11	12	0	1	0	1	0	0	0	3	2	2	1	3	2	4	5	3	2	1	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr10:90122454C>T	uc001kfe.2	-	5	690	c.555G>A	c.(553-555)CTG>CTA	p.L185L	RNLS_uc010qms.1_Silent_p.L102L|RNLS_uc001kfd.2_Silent_p.L185L|RNLS_uc009xtj.2_Silent_p.L17L	NM_001031709	NP_001026879	Q5VYX0	RNLS_HUMAN	renalase isoform 1	185						extracellular region	oxidoreductase activity			ovary(1)	1						TCACAGCCTCCAGTTGCTGCC	0.408													18	51					0	0	0	0	T	90122454	T	T	90122454	2	4	50	1	0	0	0	0	0	0	0	1	13570	581	21	4		4	RNLS	10	90122454	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	2639566	90122454	45412293	132	10011											
ANKRD2	26287	broad.mit.edu	37	chr10	99343356	99343356	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaagaccccgacggacctGgtgcagctctggcaggctga	9	5	15	12	2	1	2	0	1	1	1	1	5	1	4	3	5	2	4	3	5	1	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr10:99343356G>C	uc001knw.2	+	9	1166	c.957G>C	c.(955-957)CTG>CTC	p.L319L	DHDPSL_uc001knx.2_5'Flank|DHDPSL_uc001kny.2_5'Flank|DHDPSL_uc001knz.2_5'Flank|PI4K2A_uc010qoy.1_5'Flank|ANKRD2_uc009xvu.2_Silent_p.L286L	NM_020349	NP_065082	Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 isoform a	319					muscle contraction|muscle organ development		structural constituent of muscle				0		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		CGACGGACCTGGTGCAGCTCT	0.622													7	11					0	0	0	0	C	99343356	C	C	99343356	2	2	50	1	0	0	0	0	0	0	0	1	647	1335	47	4		4	ANKRD2	10	99343356	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	9220902	99343356	36191391	133	10012											
NT5C2	22978	broad.mit.edu	37	chr10	104860861	104860861	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggccaacaggtaggtctcTgaaaaatgaagaacagatat	17	7	10	7	0	1	4	0	2	1	2	2	4	1	4	1	3	2	1	1	3	7	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr10:104860861T>C	uc001kwo.2	-	8	668	c.482_splice	c.e8-1	p.E161_splice	NT5C2_uc010qqp.1_Splice_Site_p.E132_splice|NT5C2_uc001kwq.2_Splice_Site_p.E161_splice|NT5C2_uc001kwp.2_Splice_Site	NM_012229	NP_036361	P49902	5NTC_HUMAN	5'-nucleotidase, cytosolic II						purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|metal ion binding|nucleotide binding|protein binding				0		all_hematologic(284;0.176)|Colorectal(252;0.178)		Epithelial(162;1.33e-08)|all cancers(201;1.04e-07)|BRCA - Breast invasive adenocarcinoma(275;0.159)	Adenosine triphosphate(DB00171)|Ribavirin(DB00811)	GGTAGGTCTCTGAAAAATGAA	0.308													15	52					0	0	0	0	C	104860861	C	C	104860861	5	2	50	1	0	0	0	0	0	0	1	0	10741	1594	55	5	1253	5	NT5C2	10	104860861	Splice_Site	SNP	T	TCGA-CN-4739-01A-02D-1512-08	5517505	104860861	30673886	134	10013											
C10orf118	55088	broad.mit.edu	37	chr10	115895718	115895718	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcagatcttctagttcctTtattttggcatgatgcatct	7	19	6	9	0	4	2	1	1	3	1	5	2	5	2	1	1	1	3	1	1	2	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr10:115895718T>A	uc001lbb.1	-	9	2096	c.1444A>T	c.(1444-1446)AAG>TAG	p.K482*	C10orf118_uc009xyd.1_Nonsense_Mutation_p.K80*|C10orf118_uc001lbc.1_Nonsense_Mutation_p.K482*|C10orf118_uc009xye.1_RNA	NM_018017	NP_060487	Q7Z3E2	CJ118_HUMAN	CTCL tumor antigen L14-2	482	Potential.									ovary(2)	2		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		TCTAGTTCCTTTATTTTGGCA	0.333													45	101					0	0	0	0	A	115895718	A	A	115895718	4	1	50	1	0	0	0	0	0	1	0	0	1593	1850	64	5	1284	5	C10orf118	10	115895718	Nonsense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	11034857	115895718	19639029	135	10014											
ATRNL1	26033	broad.mit.edu	37	chr10	117226686	117226686	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattttcttttctggtagtcGaacaaaaatctggatatatc	12	17	6	6	1	3	0	0	0	3	0	5	2	3	1	0	2	1	1	0	2	7	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr10:117226686G>T	uc001lcg.2	+	23	3806	c.3420G>T	c.(3418-3420)TCG>TCT	p.S1140S	ATRNL1_uc010qsm.1_Silent_p.S269S|ATRNL1_uc010qsn.1_Intron	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1140	Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TCTGGTAGTCGAACAAAAATC	0.274													15	84					6.31663e-08	7.23928e-08	1	0	T	117226686	T	T	117226686	2	4	50	1	0	0	0	0	0	0	0	1	1209	1045	37	3		3	ATRNL1	10	117226686	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	1330968	117226686	18308061	136	10015											
PNLIPRP1	5407	broad.mit.edu	37	chr10	118355756	118355756	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctaccccccttccaaagttCacctcattggccacagcctg	8	9	6	18	0	2	0	2	0	0	0	3	0	3	0	7	1	2	2	7	1	2	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr10:118355756C>T	uc001lco.1	+	6	514	c.496C>T	c.(496-498)CAC>TAC	p.H166Y	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.H166Y|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	166					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		TTCCAAAGTTCACCTCATTGG	0.468													94	322					0	0	0	0	T	118355756	T	T	118355756	3	4	50	1	0	0	0	0	1	0	0	0	12205	826	29	2	514	2	PNLIPRP1	10	118355756	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	1129070	118355756	17178991	137	10016											
USH1C	10083	broad.mit.edu	37	chr11	17547981	17547981	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggggagcccaggctgcctCgcacgccctgaaagagagat	10	4	14	13	2	0	3	0	1	0	2	1	5	0	4	3	3	2	2	3	3	1	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr11:17547981C>A	uc001mnf.2	-	8	696	c.587G>T	c.(586-588)CGA>CTA	p.R196L	USH1C_uc001mne.2_Missense_Mutation_p.R196L|USH1C_uc009yhb.2_Missense_Mutation_p.R196L|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Missense_Mutation_p.R160L	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	196					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						CAGGCTGCCTCGCACGCCCTG	0.597													4	41					0.00024832	0.00026384	1	0	A	17547981	A	A	17547981	3	1	50	1	0	0	0	0	1	0	0	0	17102	884	31	3	2270	3	USH1C	11	17547981	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		17547981	117458535	138	10017											
TTC17	55761	broad.mit.edu	37	chr11	43513568	43513568	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accattctccttcttctcccAggatgtgcccctgattagcc	6	13	6	16	0	3	1	0	1	3	0	5	2	3	2	6	1	2	0	6	1	1	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr11:43513568A>T	uc001mxi.2	+	23	3165	c.3151_splice	c.e23-2	p.D1051_splice	TTC17_uc010rfj.1_Splice_Site_p.D1051_splice|TTC17_uc001mxl.2_Splice_Site_p.D107_splice|TTC17_uc001mxm.2_Splice_Site_p.D32_splice	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17								binding			ovary(5)	5						TTCTTCTCCCAGGATGTGCCC	0.468													113	267					0	0	0	0	T	43513568	T	T	43513568	5	4	50	1	0	0	0	0	0	0	1	0	16752	202	7	5	3239	5	TTC17	11	43513568	Splice_Site	SNP	A	TCGA-CN-4739-01A-02D-1512-08	25965587	43513568	91492948	139	10018											
OR5D13	390142	broad.mit.edu	37	chr11	55541467	55541468	+	Missense_Mutation	DNP	TA	CT	CT																															ttttatctgtgaccactctgTaattgtttctgcctcctact																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr11:55541467_55541468TA>CT	uc010ril.1	+	1	554_555	c.554_555TA>CT	c.(553-555)GTA>GCT	p.V185A		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				GACCACTCTGTAATTGTTTCTG	0.386													33	204					0	0	0	0	CT	55541468	CT	CT	55541467	3	2	50	1	0	0	0	0	1	0	0	0	11208	1638	57	5	556	5	OR5D13	11	55541467	Missense_Mutation	DNP	TA	TCGA-CN-4739-01A-02D-1512-08	12027899	55541467	79465049	140	10019											
OR8J1	219477	broad.mit.edu	37	chr11	56128342	56128342	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatatctgcagcaacaaatgTggttggttccttgattatag	11	15	9	6	0	1	1	0	1	1	0	2	1	2	1	1	2	3	4	1	2	6	7			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr11:56128342T>C	uc010rjh.1	+	1	620	c.620T>C	c.(619-621)GTG>GCG	p.V207A		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GCAACAAATGTGGTTGGTTCC	0.308													37	118					0	0	0	0	C	56128342	C	C	56128342	3	2	50	1	0	0	0	0	1	0	0	0	11295	1696	59	5	622	5	OR8J1	11	56128342	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	586875	56128342	78878174	141	10020											
ADRBK1	156	broad.mit.edu	37	chr11	67047163	67047163	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagcaggtgcctccggatCtcttccaggtgtgtgcctcc	6	10	12	13	1	1	1	0	0	1	1	5	2	4	2	5	3	3	1	5	3	1	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr11:67047163C>A	uc009yrn.1	+	5	699	c.433C>A	c.(433-435)CTC>ATC	p.L145I	ADRBK1_uc009yrm.1_Missense_Mutation_p.L145I	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	145	RGS.|N-terminal.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCCTCCGGATCTCTTCCAGGT	0.632													26	97					7.92952e-12	9.59065e-12	1	0	A	67047163	A	A	67047163	3	1	50	1	0	0	0	0	1	0	0	0	343	913	32	2	451	2	ADRBK1	11	67047163	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	10918821	67047163	67959353	142	10021											
SHANK2	22941	broad.mit.edu	37	chr11	70331650	70331650	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcactgcccggcgggggcGggggagcgggcggggggata	4	2	26	9	5	0	0	0	0	0	0	0	2	0	2	1	10	2	1	1	10	1	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr11:70331650G>A	uc001oqc.2	-	21	4826	c.4748C>T	c.(4747-4749)CCG>CTG	p.P1583L	SHANK2_uc010rqn.1_Missense_Mutation_p.P995L|SHANK2_uc001opz.2_Missense_Mutation_p.P988L|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1204					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			cggcgggggcgggggagcggg	0.418													29	160					0	0	0	0	A	70331650	A	A	70331650	3	1	50	1	0	0	0	0	1	0	0	0	14330	1116	39	1	809	1	SHANK2	11	70331650	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	3284487	70331650	64674866	143	10022											
ATM	472	broad.mit.edu	37	chr11	108160406	108160406	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttataagaagcacagaatTcttaaaatatatcacctgtt	16	14	5	6	0	2	2	1	0	1	2	2	2	2	2	1	0	1	3	1	0	8	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr11:108160406T>C	uc001pkb.1	+	29	4699	c.4314T>C	c.(4312-4314)ATT>ATC	p.I1438I	ATM_uc009yxr.1_Silent_p.I1438I|ATM_uc001pkd.3_Silent_p.I90I|ATM_uc001pke.1_Silent_p.I90I|ATM_uc010rvw.1_Silent_p.I90I|ATM_uc001pkf.2_Silent_p.I90I	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1438					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGCACAGAATTCTTAAAATAT	0.318			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			9	102					0	0	0	0	C	108160406	C	C	108160406	2	2	50	1	0	0	0	0	0	0	0	1	1111	1771	62	5		5	ATM	11	108160406	Silent	SNP	T	TCGA-CN-4739-01A-02D-1512-08	37828756	108160406	26846110	144	10023											
HINFP	25988	broad.mit.edu	37	chr11	119003216	119003216	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cccaccccagagcagcacttCcagtgttctcactgttccaa	9	9	6	17	0	1	1	1	0	1	1	4	1	3	1	5	0	2	4	5	0	1	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr11:119003216C>G	uc001pvp.2	+	7	876	c.687C>G	c.(685-687)TTC>TTG	p.F229L	HINFP_uc001pvq.2_Missense_Mutation_p.F229L|HINFP_uc001pvr.2_5'UTR	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	229	C2H2-type 5.				DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						AGCAGCACTTCCAGTGTTCTC	0.592													35	73					0	0	0	0	G	119003216	G	G	119003216	3	3	50	1	0	0	0	0	1	0	0	0	7149	854	30	2	705	2	HINFP	11	119003216	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	10842810	119003216	16003300	145	10024											
USP2	9099	broad.mit.edu	37	chr11	119243870	119243870	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaatccgctgcccccgctGaggccactgcctaaaggccg	7	5	13	16	3	0	1	0	1	0	0	1	2	1	2	6	3	2	2	6	3	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr11:119243870G>T	uc001pwm.3	-	2	616	c.321C>A	c.(319-321)CTC>CTA	p.L107L	USP2_uc001pwn.3_Intron	NM_004205	NP_004196	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2 isoform a	107	Necessary for interaction with MDM4.				cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			ovary(2)|urinary_tract(1)|skin(1)	4		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		TGCCCCCGCTGAGGCCACTGC	0.637													32	207					2.08457e-15	2.63586e-15	1	0	T	119243870	T	T	119243870	2	4	50	1	0	0	0	0	0	0	0	1	17119	1277	45	2		2	USP2	11	119243870	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	240654	119243870	15762646	146	10025											
TECTA	7007	broad.mit.edu	37	chr11	121016545	121016545	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgggtgaagagggacacCttctgccaggtgggctgtgg	7	8	18	8	0	1	2	0	1	1	1	1	3	1	3	2	5	2	2	2	5	1	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr11:121016545C>A	uc010rzo.1	+	11	3825	c.3825C>A	c.(3823-3825)ACC>ACA	p.T1275T		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1275	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGAGGGACACCTTCTGCCAGG	0.592													52	158					1.81118e-26	2.37863e-26	1	0	A	121016545	A	A	121016545	2	1	50	1	0	0	0	0	0	0	0	1	15813	668	24	4		4	TECTA	11	121016545	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	1772675	121016545	13989971	147	10026											
CACNA1C	775	broad.mit.edu	37	chr12	2705075	2705075	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccgcattgtcaatgacaCgatcttcaccaacctgatcc	11	9	5	16	2	3	2	2	2	1	0	4	3	4	2	5	0	1	1	5	0	2	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:2705075C>T	uc009zdu.1	+	20	3012	c.2699C>T	c.(2698-2700)ACG>ATG	p.T900M	CACNA1C_uc009zdv.1_Missense_Mutation_p.T897M|CACNA1C_uc001qkb.2_Missense_Mutation_p.T900M|CACNA1C_uc001qkc.2_Missense_Mutation_p.T900M|CACNA1C_uc001qke.2_Missense_Mutation_p.T900M|CACNA1C_uc001qkf.2_Missense_Mutation_p.T900M|CACNA1C_uc001qjz.2_Missense_Mutation_p.T900M|CACNA1C_uc001qkd.2_Missense_Mutation_p.T900M|CACNA1C_uc001qkg.2_Missense_Mutation_p.T900M|CACNA1C_uc009zdw.1_Missense_Mutation_p.T900M|CACNA1C_uc001qkh.2_Missense_Mutation_p.T900M|CACNA1C_uc001qkl.2_Missense_Mutation_p.T900M|CACNA1C_uc001qkn.2_Missense_Mutation_p.T900M|CACNA1C_uc001qko.2_Missense_Mutation_p.T900M|CACNA1C_uc001qkp.2_Missense_Mutation_p.T900M|CACNA1C_uc001qkr.2_Missense_Mutation_p.T900M|CACNA1C_uc001qku.2_Missense_Mutation_p.T900M|CACNA1C_uc001qkq.2_Missense_Mutation_p.T900M|CACNA1C_uc001qks.2_Missense_Mutation_p.T900M|CACNA1C_uc001qkt.2_Missense_Mutation_p.T900M|CACNA1C_uc001qka.1_Missense_Mutation_p.T435M|CACNA1C_uc001qki.1_Missense_Mutation_p.T636M|CACNA1C_uc001qkj.1_Missense_Mutation_p.T636M|CACNA1C_uc001qkk.1_Missense_Mutation_p.T636M|CACNA1C_uc001qkm.1_Missense_Mutation_p.T636M|CACNA1C_uc001qkw.2_Missense_Mutation_p.T189M	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	900	III.|Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GTCAATGACACGATCTTCACC	0.562													21	78					0	0	0	0	T	2705075	T	T	2705075	3	4	50	1	0	0	0	0	1	0	0	0	2552	536	19	1	2885	1	CACNA1C	12	2705075	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		2705075	131146820	148	10027											
FGF23	8074	broad.mit.edu	37	chr12	4479556	4479557	+	Frame_Shift_Ins	INS	-	A	A																															ccttccgggcccgttcccccINSagcgtgcgtgttcactcgac																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:4479556_4479557insA	uc001qmq.1	-	3	854_855	c.708_709insT	c.(706-711)GCTGGGfs	p.A236fs		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	236_237					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CCCGTTCCCCCAGCGTGCGTGT	0.649													---	---	---								A	4479557	A	A	4479556	7	5	50	1	0	1	1	0	0	0	0	0	5884	594	21	0	50	0	FGF23	12	4479556	Frame_Shift_Ins	INS	-	TCGA-CN-4739-01A-02D-1512-08	1774481	4479556	129372339	149	10028											
FGF23	8074	broad.mit.edu	37	chr12	4479673	4479673	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccggggccggggtcatccGggcccggggcttcagcacgt	3	5	19	14	5	2	0	2	0	0	0	3	0	3	0	4	8	1	2	4	8	0	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:4479673G>A	uc001qmq.1	-	3	738	c.592C>T	c.(592-594)CGG>TGG	p.R198W		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	198					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			GGGGTCATCCGGGCCCGGGGC	0.697													12	50					0	0	0	0	A	4479673	A	A	4479673	3	1	50	1	0	0	0	0	1	0	0	0	5884	1115	39	1	167	1	FGF23	12	4479673	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	117	4479673	129372222	150	10029											
TMTC1	83857	broad.mit.edu	37	chr12	29786262	29786262	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccaagaggtaggaataggTgaggaatctataaagagaag	17	6	15	3	0	1	3	0	1	1	2	1	6	1	5	1	5	0	1	1	5	9	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:29786262T>C	uc001rjb.2	-	6	1096	c.622A>G	c.(622-624)ACC>GCC	p.T208A	TMTC1_uc001riz.2_5'UTR|TMTC1_uc001rja.2_Missense_Mutation_p.T52A|TMTC1_uc001rjc.1_Missense_Mutation_p.T270A	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	316	Helical; (Potential).					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TAGGAATAGGTGAGGAATCTA	0.438													8	120					0	0	0	0	C	29786262	C	C	29786262	3	2	50	1	0	0	0	0	1	0	0	0	16326	1696	59	5	1754	5	TMTC1	12	29786262	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	25306589	29786262	104065633	151	10030											
YARS2	51067	broad.mit.edu	37	chr12	32903773	32903773	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcatgatatgatcaatcTctggaaggggcaggaaagtg	12	9	14	6	0	2	2	1	2	1	0	3	4	2	4	0	4	1	3	0	4	4	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:32903773T>A	uc001rli.2	-	3	1049	c.983A>T	c.(982-984)GAG>GTG	p.E328V		NM_001040436	NP_001035526	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	328					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity				0	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	ATGATCAATCTCTGGAAGGGG	0.423													30	122					0	0	0	0	A	32903773	A	A	32903773	3	1	50	1	0	0	0	0	1	0	0	0	17536	1551	54	5	462	5	YARS2	12	32903773	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	3117511	32903773	100948122	152	10031											
PDZRN4	29951	broad.mit.edu	37	chr12	41961614	41961614	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggctggctggaagatgaaagGaatgaattcttagaggagtt	13	10	15	3	0	1	4	0	2	1	2	1	7	1	7	0	5	0	3	0	5	5	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:41961614G>A	uc010skn.1	+	9	968	c.900G>A	c.(898-900)AGG>AGA	p.R300R	PDZRN4_uc001rmq.3_Silent_p.R241R|PDZRN4_uc009zjz.2_Silent_p.R239R|PDZRN4_uc001rmr.2_Silent_p.R126R	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	499							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AAGATGAAAGGAATGAATTCT	0.388													21	78					0	0	0	0	A	41961614	A	A	41961614	2	1	50	1	0	0	0	0	0	0	0	1	11764	1165	41	2		2	PDZRN4	12	41961614	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	9057841	41961614	91890281	153	10032											
NAV3	89795	broad.mit.edu	37	chr12	78511822	78511822	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatagctgaggacagattcaGagaaacgctccaccacagac	15	6	9	11	1	1	4	1	1	0	3	2	6	2	5	2	1	2	2	2	1	3	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:78511822G>A	uc001syp.2	+	14	2958	c.2785G>A	c.(2785-2787)GAG>AAG	p.E929K	NAV3_uc001syo.2_Missense_Mutation_p.E929K|NAV3_uc010sub.1_Missense_Mutation_p.E429K|NAV3_uc009zsf.2_5'UTR	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	929						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GACAGATTCAGAGAAACGCTC	0.378										HNSCC(70;0.22)			40	186					0	0	0	0	A	78511822	A	A	78511822	3	1	50	1	0	0	0	0	1	0	0	0	10238	943	33	2	2839	2	NAV3	12	78511822	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	36550208	78511822	55340073	154	10033											
PPFIA2	8499	broad.mit.edu	37	chr12	81768486	81768486	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagcctttctcatggtcTgctgcaacttttgttcagct	5	18	7	11	0	4	0	3	0	2	0	5	0	4	0	1	1	5	4	1	1	1	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:81768486T>A	uc001szo.1	-	11	1354	c.1193A>T	c.(1192-1194)CAG>CTG	p.Q398L	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	324										ovary(3)|lung(2)|pancreas(1)	6						TCTCATGGTCTGCTGCAACTT	0.463													42	109					0	0	0	0	A	81768486	A	A	81768486	3	1	50	1	0	0	0	0	1	0	0	0	12365	1580	55	5	2668	5	PPFIA2	12	81768486	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	3256664	81768486	52083409	155	10034											
GALNT4	8693	broad.mit.edu	37	chr12	89918285	89918285	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccactgttaaaaacgccagCagcaggcagctcttgcctgc	10	7	10	14	1	1	0	0	0	1	0	1	0	1	0	3	1	6	5	3	1	3	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:89918285C>T	uc001tbd.2	-	1	251	c.42G>A	c.(40-42)CTG>CTA	p.L14L	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Intron|GALNT4_uc010suo.1_Intron	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	14	Helical; Signal-anchor for type II membrane protein; (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						AAAACGCCAGCAGCAGGCAGC	0.622											OREG0022018	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	80					0	0	0	0	T	89918285	T	T	89918285	2	4	50	1	0	0	0	0	0	0	0	1	6250	697	25	4		4	GALNT4	12	89918285	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	8149799	89918285	43933610	156	10035											
APAF1	317	broad.mit.edu	37	chr12	99056498	99056498	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagttccttaggaaaggaaaAaggacttgaaattttatccc	15	11	9	6	0	0	1	0	1	0	0	2	5	2	4	2	3	0	1	2	3	6	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:99056498A>G	uc001tfz.2	+	7	1446	c.869A>G	c.(868-870)AAA>AGA	p.K290R	APAF1_uc001tfy.2_Missense_Mutation_p.K279R|APAF1_uc001tga.2_Missense_Mutation_p.K279R|APAF1_uc001tgb.2_Missense_Mutation_p.K290R|APAF1_uc001tgc.2_Missense_Mutation_p.K290R	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	290	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	GGAAAGGAAAAAGGACTTGAA	0.313													20	82					0	0	0	0	G	99056498	G	G	99056498	3	3	50	1	0	0	0	0	1	0	0	0	755	14	1	5	891	5	APAF1	12	99056498	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	9138213	99056498	34795397	157	10036											
SLC5A8	160728	broad.mit.edu	37	chr12	101576647	101576647	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtaaggtttgattagatCttccacagttactgctgcta	11	14	9	7	0	1	2	0	1	1	1	2	3	2	2	1	1	3	5	1	1	5	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:101576647C>A	uc001thz.3	-	9	1489	c.1099G>T	c.(1099-1101)GAT>TAT	p.D367Y		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	367	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						TTGATTAGATCTTCCACAGTT	0.343													25	127					1.32003e-05	1.44778e-05	1	0	A	101576647	A	A	101576647	3	1	50	1	0	0	0	0	1	0	0	0	14735	913	32	2	761	2	SLC5A8	12	101576647	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	2520149	101576647	32275248	158	10037											
DTX1	1840	broad.mit.edu	37	chr12	113515368	113515368	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcaccatccagaacgcctaCgagaagcagcacccgtggct	12	5	9	15	3	1	2	1	0	0	2	2	3	2	2	4	1	4	3	4	1	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr12:113515368C>T	uc001tuk.1	+	2	735	c.399C>T	c.(397-399)TAC>TAT	p.Y133Y		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	133	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						AGAACGCCTACGAGAAGCAGC	0.567													4	63					0	0	0	0	T	113515368	T	T	113515368	2	4	50	1	0	0	0	0	0	0	0	1	4815	547	19	1		1	DTX1	12	113515368	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	11938721	113515368	20336527	159	10038											
PDS5B	23047	broad.mit.edu	37	chr13	33334734	33334734	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaacaaccaatgttctaGgagctgttaacaagccactt	15	10	6	10	0	1	0	0	0	1	0	1	1	1	1	2	1	5	3	2	1	7	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr13:33334734G>C	uc010abf.2	+	30	3552	c.3394G>C	c.(3394-3396)GGA>CGA	p.G1132R	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	1132					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		CAATGTTCTAGGAGCTGTTAA	0.383													19	62					0	0	0	0	C	33334734	C	C	33334734	3	2	50	1	0	0	0	0	1	0	0	0	11746	1001	35	4	3508	4	PDS5B	13	33334734	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08		33334734	81835144	160	10039											
FAM124A	220108	broad.mit.edu	37	chr13	51826206	51826206	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accagtgcccggtgcccaccGactcctccgtgctggagttc	5	8	11	17	3	0	0	0	0	0	0	3	2	2	1	6	2	3	2	6	2	0	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr13:51826206G>A	uc001vfg.1	+	3	834	c.703G>A	c.(703-705)GAC>AAC	p.D235N	FAM124A_uc001vfe.2_Missense_Mutation_p.D235N|FAM124A_uc001vff.1_Missense_Mutation_p.D271N	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	235										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		GGTGCCCACCGACTCCTCCGT	0.602													35	70					0	0	0	0	A	51826206	A	A	51826206	3	1	50	1	0	0	0	0	1	0	0	0	5453	1058	37	1	825	1	FAM124A	13	51826206	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	18491472	51826206	63343672	161	10040											
DZIP1	22873	broad.mit.edu	37	chr13	96242634	96242634	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttctctttcttgcttatgtCtttctgattccacacttttt	4	24	3	10	0	4	1	0	1	4	0	6	1	5	1	1	0	1	1	1	0	1	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr13:96242634C>T	uc001vmk.2	-	17	2594	c.1742G>A	c.(1741-1743)AGA>AAA	p.R581K	DZIP1_uc001vmi.2_5'Flank|DZIP1_uc001vmj.2_Missense_Mutation_p.R57K|DZIP1_uc001vml.2_Missense_Mutation_p.R562K	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	581	Potential.				germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TTGCTTATGTCTTTCTGATTC	0.368													50	105					0	0	0	0	T	96242634	T	T	96242634	3	4	50	1	0	0	0	0	1	0	0	0	4885	913	32	2	889	2	DZIP1	13	96242634	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	44416428	96242634	18927244	162	10041											
CLEC14A	161198	broad.mit.edu	37	chr14	38724597	38724597	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccggcagagcgcactcacctCggtcccaggtggactgaagt	8	6	13	14	3	1	2	1	1	0	1	3	3	2	3	3	4	1	2	3	4	1	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr14:38724597C>T	uc001wum.1	-	1	978	c.631G>A	c.(631-633)GAG>AAG	p.E211K		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	211	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GCACTCACCTCGGTCCCAGGT	0.547													76	176					0	0	0	0	T	38724597	T	T	38724597	3	4	50	1	0	0	0	0	1	0	0	0	3514	893	31	1	845	1	CLEC14A	14	38724597	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		38724597	68624943	163	10042											
FAM179B	23116	broad.mit.edu	37	chr14	45431656	45431656	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctccgcgctgcttctgcTgccgccctttccagtcctct	1	12	7	21	3	2	0	0	0	2	0	5	0	5	0	7	0	3	3	7	0	0	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr14:45431656T>A	uc001wvv.2	+	1	241	c.32T>A	c.(31-33)CTG>CAG	p.L11Q	FAM179B_uc001wvw.2_Missense_Mutation_p.L11Q|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.L11Q|FAM179B_uc001wvu.2_Missense_Mutation_p.L11Q	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	11							binding			skin(2)|upper_aerodigestive_tract(1)	3						CTGCTTCTGCTGCCGCCCTTT	0.612													4	49					0	0	0	0	A	45431656	A	A	45431656	3	1	50	1	0	0	0	0	1	0	0	0	5534	1580	55	5	34	5	FAM179B	14	45431656	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	6707059	45431656	61917884	164	10043											
C14orf106	55320	broad.mit.edu	37	chr14	45711704	45711704	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaaaaattttcctgttcttGgttcagagttggaagttctg	10	16	9	6	0	3	1	1	0	2	1	4	2	4	2	1	2	0	4	1	2	4	7			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr14:45711704G>C	uc001wwf.2	-	4	1135	c.676C>G	c.(676-678)CAA>GAA	p.Q226E	C14orf106_uc010anh.2_RNA	NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	226					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TCCTGTTCTTGGTTCAGAGTT	0.303													38	108					0	0	0	0	C	45711704	C	C	45711704	3	2	50	1	0	0	0	0	1	0	0	0	1744	1357	47	4	2778	4	C14orf106	14	45711704	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	280048	45711704	61637836	165	10044											
TMEM229B	161145	broad.mit.edu	37	chr14	67940192	67940192	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggcgccgctgggctccccgGgctcagcgtccttgtcgaag	3	7	16	15	5	1	0	1	0	0	0	4	1	3	0	4	3	1	3	4	3	1	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr14:67940192G>T	uc001xjk.2	-	3	859	c.449C>A	c.(448-450)CCC>CAC	p.P150H	TMEM229B_uc001xjj.1_RNA	NM_182526	NP_872332	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	150	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1						GGGCTCCCCGGGCTCAGCGTC	0.657													15	81					2.32078e-09	2.71053e-09	1	0	T	67940192	T	T	67940192	3	4	50	1	0	0	0	0	1	0	0	0	16214	1232	43	4	58	4	TMEM229B	14	67940192	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	22228488	67940192	39409348	166	10045											
ASPG	374569	broad.mit.edu	37	chr14	104561928	104561928	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaccgacaccatggcctttGctgcctcgatgctgtccttc	5	11	9	16	2	0	0	0	0	0	0	3	2	1	0	5	1	3	3	5	1	0	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr14:104561928G>A	uc001yoq.1	+	4	424	c.364G>A	c.(364-366)GCT>ACT	p.A122T	ASPG_uc001yoo.1_Missense_Mutation_p.A150T|ASPG_uc001yop.1_Missense_Mutation_p.A122T|ASPG_uc001yor.1_Missense_Mutation_p.A122T	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	122	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						CATGGCCTTTGCTGCCTCGAT	0.637													35	63					0	0	0	0	A	104561928	A	A	104561928	3	1	50	1	0	0	0	0	1	0	0	0	1054	1319	46	4	378	4	ASPG	14	104561928	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	36621736	104561928	2787612	167	10046											
MTA1	9112	broad.mit.edu	37	chr14	105932764	105932764	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgtgtcattcccggcagaGacccacccccgcccccccaa	7	5	7	22	2	1	1	1	0	0	1	2	2	2	1	8	1	0	1	8	1	1	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr14:105932764G>A	uc001yqx.2	+	17	1813	c.1626G>A	c.(1624-1626)GAG>GAA	p.E542E	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Silent_p.E303E	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	542					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		TCCCGGCAGAGACCCACCCCC	0.682													5	6					0	0	0	0	A	105932764	A	A	105932764	2	1	50	1	0	0	0	0	0	0	0	1	9961	956	33	2		2	MTA1	14	105932764	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	1370836	105932764	1416776	168	10047											
C15orf2	23742	broad.mit.edu	37	chr15	24922320	24922320	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggctgacctggctactggaCccctcatcctgcctatccct	5	11	8	17	0	1	1	1	1	0	0	3	2	3	2	6	3	2	2	6	3	2	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr15:24922320C>A	uc001ywo.2	+	1	1780	c.1306C>A	c.(1306-1308)CCC>ACC	p.P436T		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	436	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GGCTACTGGACCCCTCATCCT	0.542													37	105					6.70999e-13	8.21302e-13	1	0	A	24922320	A	A	24922320	3	1	50	1	0	0	0	0	1	0	0	0	1790	507	18	4	1308	4	C15orf2	15	24922320	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		24922320	77609072	169	10048											
GOLGA6C	653641	broad.mit.edu	37	chr15	75557691	75557691	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taaaacaagtccagctagagCgggacgaatatgctaaacac	17	6	9	9	2	0	1	0	0	0	1	1	3	1	2	1	1	5	2	1	1	8	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr15:75557691C>T	uc002azs.1	+	9	726	c.649C>T	c.(649-651)CGG>TGG	p.R217W	uc002azt.1_5'Flank	NM_001145224	NP_001138696	A6NDK9	GOG6C_HUMAN	golgi autoantigen, golgin subfamily a, 6D	229	Potential.									ovary(1)	1						CCAGCTAGAGCGGGACGAATA	0.547													67	399					0	0	0	0	T	75557691	T	T	75557691	3	4	50	1	0	0	0	0	1	0	0	0	6596	759	27	1	719	1	GOLGA6C	15	75557691	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	50635371	75557691	26973701	170	10049											
ADAMTS7	11173	broad.mit.edu	37	chr15	79089014	79089014	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggcatcagctactaccaggGtctccacccacttctctttg	7	12	7	15	0	3	0	1	0	2	0	5	0	3	0	3	2	3	2	3	2	2	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr15:79089014G>T	uc002bej.3	-	4	948	c.737C>A	c.(736-738)ACC>AAC	p.T246N	ADAMTS7_uc010und.1_Missense_Mutation_p.T246N|ADAMTS7_uc002bek.1_Missense_Mutation_p.T246N	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	246	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						TACTACCAGGGTCTCCACCCA	0.403													10	190					2.80697e-09	3.25354e-09	1	0	T	79089014	T	T	79089014	3	4	50	1	0	0	0	0	1	0	0	0	271	1261	44	4	4407	4	ADAMTS7	15	79089014	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	3531323	79089014	23442378	171	10050											
IGF1R	3480	broad.mit.edu	37	chr15	99467897	99467897	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggacagatcctgtgttcttCtatgtccaggccaaaagtaa	11	12	9	9	0	2	1	0	0	2	1	4	2	4	2	3	2	0	2	3	2	4	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr15:99467897C>T	uc002bul.2	+	13	2816	c.2766C>T	c.(2764-2766)TTC>TTT	p.F922F	IGF1R_uc010bon.2_Silent_p.F922F|IGF1R_uc010boo.1_RNA	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	922	Extracellular (Potential).|Fibronectin type-III 3.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CTGTGTTCTTCTATGTCCAGG	0.547													18	98					0	0	0	0	T	99467897	T	T	99467897	2	4	50	1	0	0	0	0	0	0	0	1	7610	912	32	2		2	IGF1R	15	99467897	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	20378883	99467897	3063495	172	10051											
WDR24	84219	broad.mit.edu	37	chr16	739435	739435	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaggttaagcgaaggcttgCgccccacacgcaggttcagc	9	7	12	13	3	2	0	2	0	0	0	2	1	2	0	2	3	3	4	2	3	2	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:739435C>A	uc002ciz.1	-	1	966	c.206G>T	c.(205-207)CGC>CTC	p.R69L		NM_032259	NP_115635	Q96S15	WDR24_HUMAN	WD repeat domain 24	131										ovary(1)|central_nervous_system(1)	2		Hepatocellular(780;0.0218)				CGAAGGCTTGCGCCCCACACG	0.602													25	54					5.35047e-06	5.93204e-06	1	0	A	739435	A	A	739435	3	1	50	1	0	0	0	0	1	0	0	0	17349	768	27	3	2202	3	WDR24	16	739435	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		739435	89615318	173	10052											
PKD1	5310	broad.mit.edu	37	chr16	2164578	2164578	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccactggggagaccacgtCaaagctgcaggagaggttgt	11	6	15	9	1	1	2	1	0	0	2	1	4	1	2	2	4	3	3	2	4	1	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:2164578C>A	uc002cos.1	-	11	2655	c.2446G>T	c.(2446-2448)GAC>TAC	p.D816Y	PKD1_uc002cot.1_Missense_Mutation_p.D816Y	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	816	PKD 2.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GAGACCACGTCAAAGCTGCAG	0.682													6	8					0.00198382	0.00207893	1	0	A	2164578	A	A	2164578	3	1	50	1	0	0	0	0	1	0	0	0	12018	826	29	2	10609	2	PKD1	16	2164578	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	1425143	2164578	88190175	174	10053											
C16orf62	57020	broad.mit.edu	37	chr16	19612993	19612993	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cttttcctcccaggaaagctCgtgtacgagcgcatcttttc	7	13	8	13	3	1	0	0	0	1	0	5	2	3	1	2	1	3	3	2	1	2	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:19612993C>G	uc002dgn.1	+	9	744	c.732C>G	c.(730-732)CTC>CTG	p.L244L	C16orf62_uc002dgo.1_Silent_p.L244L|C16orf62_uc002dgp.1_5'UTR|C16orf62_uc010vas.1_Silent_p.L118L|C16orf62_uc002dgm.1_Silent_p.L244L	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	244						integral to membrane				ovary(1)	1						CAGGAAAGCTCGTGTACGAGC	0.483											OREG0023661	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	92					0	0	0	0	G	19612993	G	G	19612993	2	3	50	1	0	0	0	0	0	0	0	1	1831	871	31	3		3	C16orf62	16	19612993	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	17448415	19612993	70741760	175	10054											
RBBP6	5930	broad.mit.edu	37	chr16	24580864	24580864	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgagggttttctgaacccAgagttattagagacttctag	11	13	11	6	0	2	4	0	2	2	2	2	5	2	4	1	1	1	2	1	1	4	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:24580864A>T	uc002dmh.2	+	17	3893	c.2853A>T	c.(2851-2853)CCA>CCT	p.P951P	RBBP6_uc010vcb.1_Silent_p.P818P|RBBP6_uc002dmi.2_Silent_p.P917P|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Silent_p.P784P	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	951					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TTCTGAACCCAGAGTTATTAG	0.398													13	48					0	0	0	0	T	24580864	T	T	24580864	2	4	50	1	0	0	0	0	0	0	0	1	13168	175	7	5		5	RBBP6	16	24580864	Silent	SNP	A	TCGA-CN-4739-01A-02D-1512-08	4967871	24580864	65773889	176	10055											
ATXN2L	11273	broad.mit.edu	37	chr16	28840776	28840776	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaatgaggagaactacggtGtgaagactacctatgatagc	14	9	11	7	1	1	5	1	3	0	2	1	6	1	5	1	2	4	0	1	2	7	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:28840776G>T	uc002drc.2	+	7	964	c.796G>T	c.(796-798)GTG>TTG	p.V266L	uc010vct.1_Intron|ATXN2L_uc010byl.1_Missense_Mutation_p.V266L|ATXN2L_uc002drb.2_Missense_Mutation_p.V266L|ATXN2L_uc002dqy.2_Missense_Mutation_p.V266L|ATXN2L_uc002dra.2_Missense_Mutation_p.V266L|ATXN2L_uc002dqz.2_Missense_Mutation_p.V266L|ATXN2L_uc010vdb.1_Missense_Mutation_p.V266L|ATXN2L_uc002dre.2_Missense_Mutation_p.V266L|ATXN2L_uc002drf.2_Intron	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	266						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						GAACTACGGTGTGAAGACTAC	0.463													23	79					1.10513e-12	1.34729e-12	1	0	T	28840776	T	T	28840776	3	4	50	1	0	0	0	0	1	0	0	0	1214	1377	48	4	822	4	ATXN2L	16	28840776	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	4259912	28840776	61513977	177	10056											
NOD2	64127	broad.mit.edu	37	chr16	50763774	50763774	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctaggggcagaagccctcctGcaggcccttgaaaggaatga	11	6	13	11	0	0	3	0	2	0	1	1	4	1	4	3	4	2	2	3	4	4	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:50763774G>T	uc002egm.1	+	11	3117	c.3012G>T	c.(3010-3012)CTG>CTT	p.L1004L	NOD2_uc010vgq.1_Silent_p.L49L	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	1004	LRR 8.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				AAGCCCTCCTGCAGGCCCTTG	0.348													12	59					1.05317e-09	1.24429e-09	1	0	T	50763774	T	T	50763774	2	4	50	1	0	0	0	0	0	0	0	1	10571	1306	46	4		4	NOD2	16	50763774	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	21922998	50763774	39590979	178	10057											
RPGRIP1L	23322	broad.mit.edu	37	chr16	53686756	53686756	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaaacttcagaagaaaaggTtactttgttgatatggattt	15	15	8	3	0	1	3	1	1	0	2	1	4	1	4	0	2	2	2	0	2	7	7	rs121918198		TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:53686756T>A	uc002ehp.2	-	15	1907	c.1843A>T	c.(1843-1845)ACC>TCC	p.T615S	RPGRIP1L_uc002eho.3_Missense_Mutation_p.T615S|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.T615S|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.T615S|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.T615S	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	615	C2 1.		T -> P (in JBTS7; affects interaction with NPHP4).		negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				GAAGAAAAGGTTACTTTGTTG	0.373													10	116					0	0	0	0	A	53686756	A	A	53686756	3	1	50	1	0	0	0	0	1	0	0	0	13615	1725	60	5	2156	5	RPGRIP1L	16	53686756	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	2922982	53686756	36667997	179	10058											
RPGRIP1L	23322	broad.mit.edu	37	chr16	53708989	53708989	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcattgcttttctctactagCtgtttatgaagcttaatcat	9	18	6	8	0	2	1	1	1	1	0	3	1	2	1	0	0	4	5	0	0	5	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:53708989C>T	uc002ehp.2	-	7	886	c.822G>A	c.(820-822)CAG>CAA	p.Q274Q	RPGRIP1L_uc002eho.3_Silent_p.Q274Q|RPGRIP1L_uc010vgy.1_Silent_p.Q274Q|RPGRIP1L_uc010cbx.2_Silent_p.Q274Q|RPGRIP1L_uc010vgz.1_Silent_p.Q274Q|RPGRIP1L_uc002ehq.1_Silent_p.Q274Q	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	274					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TCTCTACTAGCTGTTTATGAA	0.323													7	107					0	0	0	0	T	53708989	T	T	53708989	2	4	50	1	0	0	0	0	0	0	0	1	13615	796	28	4		4	RPGRIP1L	16	53708989	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	22233	53708989	36645764	180	10059											
IRX6	79190	broad.mit.edu	37	chr16	55362806	55362806	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcgagagggccgattggagCgcagggagtgcggcctggct	6	6	19	10	4	0	1	0	0	0	1	1	5	0	3	2	5	2	2	2	5	0	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:55362806C>T	uc002ehy.2	+	5	1449	c.916C>T	c.(916-918)CGC>TGC	p.R306C	IRX6_uc002ehx.2_Missense_Mutation_p.R306C	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	306						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						CCGATTGGAGCGCAGGGAGTG	0.642													8	127					0	0	0	0	T	55362806	T	T	55362806	3	4	50	1	0	0	0	0	1	0	0	0	7887	768	27	1	934	1	IRX6	16	55362806	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	1653817	55362806	34991947	181	10060											
NUDT21	11051	broad.mit.edu	37	chr16	56481815	56481815	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caattttatcaaattcttccCtcatgcgctgaaatctggct	10	15	5	11	1	4	1	2	1	2	0	5	1	5	1	1	1	1	2	1	1	4	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:56481815C>G	uc002eja.2	-	2	350	c.203G>C	c.(202-204)AGG>ACG	p.R68T	NUDT21_uc002eiz.2_5'UTR	NM_007006	NP_008937	O43809	CPSF5_HUMAN	cleavage and polyadenylation specific factor 5	68	Necessary for RNA-binding.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	centrosome|mRNA cleavage factor complex|paraspeckles	AU-rich element binding|histone deacetylase binding|hydrolase activity|mRNA binding|protein homodimerization activity				0						AAATTCTTCCCTCATGCGCTG	0.473													7	122					0	0	0	0	G	56481815	G	G	56481815	3	3	50	1	0	0	0	0	1	0	0	0	10792	681	24	4	504	4	NUDT21	16	56481815	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	1119009	56481815	33872938	182	10061											
PMFBP1	83449	broad.mit.edu	37	chr16	72188154	72188154	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtgcagaagaaccaggtCggaagtctgcttctctagga	11	9	13	8	1	2	2	0	0	2	2	4	4	2	4	1	4	3	2	1	4	4	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:72188154C>A	uc002fcc.3	-	4	542	c.370G>T	c.(370-372)GAC>TAC	p.D124Y	PMFBP1_uc002fcd.2_Missense_Mutation_p.D124Y|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_5'UTR	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	124										ovary(2)	2		Ovarian(137;0.179)				AGAACCAGGTCGGAAGTCTGC	0.448													84	259					9.36137e-61	1.26751e-60	1	0	A	72188154	A	A	72188154	3	1	50	1	0	0	0	0	1	0	0	0	12189	884	31	3	2785	3	PMFBP1	16	72188154	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	15706339	72188154	18166599	183	10062											
LRRC50	123872	broad.mit.edu	37	chr16	84188370	84188370	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactggatgctcttaacctcAgcaacaattacatcaagacc	15	9	5	12	0	3	1	2	0	1	1	3	2	3	2	2	1	6	2	2	1	6	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:84188370A>T	uc002fhl.3	+	4	722	c.541A>T	c.(541-543)AGC>TGC	p.S181C	LRRC50_uc010chi.1_RNA	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	181	LRR 4.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						TCTTAACCTCAGCAACAATTA	0.473									Kartagener_syndrome				35	102					0	0	0	0	T	84188370	T	T	84188370	3	4	50	1	0	0	0	0	1	0	0	0	9059	188	7	5	555	5	LRRC50	16	84188370	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	12000216	84188370	6166383	184	10063											
COX4NB	10328	broad.mit.edu	37	chr16	85822627	85822627	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgataataaccagcaatcacGtagctatgatctttgcacca	14	11	6	10	1	2	2	1	2	1	0	2	2	2	2	2	0	4	4	2	0	5	5	rs146555773		TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:85822627G>A	uc002fjd.2	-	2	508	c.261C>T	c.(259-261)TAC>TAT	p.Y87Y	COX4NB_uc010vol.1_Silent_p.Y87Y	NM_006067	NP_006058	O43402	CX4NB_HUMAN	COX4 neighbor isoform 1	87						mitochondrion|nucleus					0						CAGCAATCACGTAGCTATGAT	0.438													11	149					0	0	0	0	A	85822627	A	A	85822627	2	1	50	1	0	0	0	0	0	0	0	1	3786	1140	40	1		1	COX4NB	16	85822627	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	1634257	85822627	4532126	185	10064											
CDH15	1013	broad.mit.edu	37	chr16	89251724	89251724	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagatccgcacagtgcaaGtggggctggaccgcgaggtg	9	5	18	9	3	0	1	0	0	0	1	1	5	1	2	2	4	1	3	2	4	1	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr16:89251724G>C	uc002fmt.2	+	5	723	c.646G>C	c.(646-648)GTG>CTG	p.V216L	CDH15_uc010cij.1_Missense_Mutation_p.V216L	NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	216	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CACAGTGCAAGTGGGGCTGGA	0.697													7	15					0	0	0	0	C	89251724	C	C	89251724	3	2	50	1	0	0	0	0	1	0	0	0	3115	1029	36	4	664	4	CDH15	16	89251724	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	3429097	89251724	1103029	186	10065											
TP53	7157	broad.mit.edu	37	chr17	7574018	7574018	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctcggaacatctcgaagcGctcacgcccacggatctgca	9	7	9	16	5	4	0	1	0	3	0	6	3	4	2	1	2	3	2	1	2	2	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:7574018G>A	uc002gim.2	-	10	1203	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Missense_Mutation_p.R205C|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Missense_Mutation_p.R337C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	337	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R337C(12)|p.0?(7)|p.R337L(5)|p.R337H(2)|p.?(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCTCGAAGCGCTCACGCCCA	0.448		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	12					0	0	0	0	A	7574018	A	A	7574018	3	1	50	1	0	0	0	0	1	0	0	0	16448	1087	38	1	180	1	TP53	17	7574018	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08		7574018	73621192	187	10066											
ERAL1	26284	broad.mit.edu	37	chr17	27185506	27185506	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcctggtcatgaacaaggTgagcactacccacctgagga	11	8	11	11	0	1	3	1	3	0	0	2	4	2	4	3	3	3	1	3	3	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:27185506T>C	uc002hcy.1	+	6	721	c.711_splice	c.e6+2	p.K237_splice	ERAL1_uc002hcz.1_Splice_Site|ERAL1_uc002hda.1_Splice_Site_p.K44_splice|ERAL1_uc002hdb.1_Splice_Site_p.K120_splice	NM_005702	NP_005693	O75616	ERAL1_HUMAN	Era-like 1						ribosomal small subunit assembly	mitochondrial inner membrane|mitochondrial matrix	GTP binding|ribosomal small subunit binding|rRNA binding			skin(1)	1	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.12e-05)|all cancers(11;5.32e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.105)			ATGAACAAGGTGAGCACTACC	0.547													62	155					0	0	0	0	C	27185506	C	C	27185506	5	2	50	1	0	0	0	0	0	0	1	0	5226	1710	59	5	735	5	ERAL1	17	27185506	Splice_Site	SNP	T	TCGA-CN-4739-01A-02D-1512-08	19611488	27185506	54009704	188	10067											
CCL8	6355	broad.mit.edu	37	chr17	32647835	32647835	+	Frame_Shift_Del	DEL	G	-	-																															ccacagcttcaagaccaaacGgggcaaggaggtctgtgctg																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:32647835delG	uc002hib.2	+	3	664	c.209delG	c.(208-210)CGGfs	p.R70fs		NM_005623	NP_005614	P80075	CCL8_HUMAN	small inducible cytokine A8 precursor	70					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity				0		Ovarian(249;0.0443)|Breast(31;0.151)				AAGACCAAACGGGGCAAGGAG	0.502													---	---	---								-	32647835	-	-	32647835	7	5	50	1	0	1	0	1	0	0	0	0	2922	1116	39	0	219	0	CCL8	17	32647835	Frame_Shift_Del	DEL	G	TCGA-CN-4739-01A-02D-1512-08	5462329	32647835	48547375	189	10068											
SLFN5	162394	broad.mit.edu	37	chr17	33586236	33586236	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgtcagctgctgctttatTtgatagaaagcggcttcagt	8	15	11	7	1	2	2	2	1	0	1	2	2	2	2	0	1	4	4	0	1	3	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:33586236T>G	uc002hjf.3	+	2	644	c.527T>G	c.(526-528)TTT>TGT	p.F176C	SLFN5_uc002hje.2_Missense_Mutation_p.F176C|SLFN5_uc010wcg.1_Missense_Mutation_p.F176C	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	176					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GCTGCTTTATTTGATAGAAAG	0.398													65	168					0	0	0	0	G	33586236	G	G	33586236	3	3	50	1	0	0	0	0	1	0	0	0	14801	1841	64	5	529	5	SLFN5	17	33586236	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	938401	33586236	47608974	190	10069											
CDK12	51755	broad.mit.edu	37	chr17	37673803	37673803	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcgtctacgagaagaatTctctttgtgagtttggggaa	11	12	13	5	2	2	3	0	1	2	2	3	5	2	4	0	3	1	1	0	3	5	4			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:37673803T>C	uc010cvv.2	+	10	3543	c.2957T>C	c.(2956-2958)TTC>TCC	p.F986S	CDK12_uc010wef.1_Missense_Mutation_p.F985S|CDK12_uc002hrw.3_Missense_Mutation_p.F986S	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	986	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						CGAGAAGAATTCTCTTTGTGA	0.468										TCGA Ovarian(9;0.13)			10	75					0	0	0	0	C	37673803	C	C	37673803	3	2	50	1	0	0	0	0	1	0	0	0	3143	1783	62	5	2995	5	CDK12	17	37673803	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	4087567	37673803	43521407	191	10070											
GHDC	84514	broad.mit.edu	37	chr17	40342689	40342689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccagcagcttggcccccGcccactgccccactgcccgg	4	5	11	21	2	0	0	0	0	0	0	1	0	1	0	7	3	4	2	7	3	0	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:40342689G>A	uc002hzd.2	-	7	1725	c.1241C>T	c.(1240-1242)GCG>GTG	p.A414V	GHDC_uc002hzg.1_Missense_Mutation_p.A414V|GHDC_uc010wgg.1_Missense_Mutation_p.A375V|GHDC_uc002hze.3_Missense_Mutation_p.A414V|GHDC_uc002hzf.3_Missense_Mutation_p.A414V	NM_032484	NP_115873	Q8N2G8	GHDC_HUMAN	LGP1 homolog isoform 1	414						endoplasmic reticulum|nuclear envelope					0		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		CTTGGCCCCCGCCCACTGCCC	0.627													4	56					0	0	0	0	A	40342689	A	A	40342689	3	1	50	1	0	0	0	0	1	0	0	0	6406	1087	38	1	452	1	GHDC	17	40342689	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	2668886	40342689	40852521	192	10071											
ASB16	92591	broad.mit.edu	37	chr17	42254108	42254109	+	Frame_Shift_Del	DEL	GC	-	-																															ttgctctcttgtccccaggtGcgccaagttgctgctggaag																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:42254108_42254109delGC	uc002ifl.1	+	3	656_657	c.572_573delGC	c.(571-573)TGCfs	p.C191fs	ASB16_uc002ifm.1_RNA|C17orf65_uc002ifn.2_Frame_Shift_Del_p.R171fs	NM_080863	NP_543139	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box-containing protein	191	ANK 4.				intracellular signal transduction		protein binding			kidney(2)	2		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GTCCCCAGGTGCGCCAAGTTGC	0.639													---	---	---								-	42254109	-	-	42254108	7	5	50	1	0	1	0	1	0	0	0	0	1022	1319	46	0	582	0	ASB16	17	42254108	Frame_Shift_Del	DEL	GC	TCGA-CN-4739-01A-02D-1512-08	1911419	42254108	38941102	193	10072											
ANKRD40	91369	broad.mit.edu	37	chr17	48777946	48777946	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctcccataatcttcctgAtttctctccttgatgttaac	8	16	3	14	0	2	2	0	2	2	0	6	2	5	2	4	0	1	1	4	0	2	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:48777946A>G	uc002iso.2	-	2	521	c.266T>C	c.(265-267)ATC>ACC	p.I89T		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	89											0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			AATCTTCCTGATTTCTCTCCT	0.418													46	130					0	0	0	0	G	48777946	G	G	48777946	3	3	50	1	0	0	0	0	1	0	0	0	669	333	12	5	856	5	ANKRD40	17	48777946	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	6523838	48777946	32417264	194	10073											
MRC2	9902	broad.mit.edu	37	chr17	60759630	60759630	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggtgcctgacagccttGccctacatctgcaagcgcag	9	7	11	14	1	1	2	0	1	1	1	1	2	1	2	3	1	6	2	3	1	2	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:60759630G>T	uc002jad.2	+	20	3240	c.2838G>T	c.(2836-2838)TTG>TTT	p.L946F	MRC2_uc002jae.2_Missense_Mutation_p.L17F|MRC2_uc002jaf.2_5'UTR	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	946	Extracellular (Potential).|C-type lectin 5.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TGACAGCCTTGCCCTACATCT	0.562													14	12					1.05317e-09	1.24429e-09	1	0	T	60759630	T	T	60759630	3	4	50	1	0	0	0	0	1	0	0	0	9811	1310	46	4	2916	4	MRC2	17	60759630	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	11981684	60759630	20435580	195	10074											
ABCA10	10349	broad.mit.edu	37	chr17	67218723	67218723	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggattctatatccccaattAaacttcaggcgatatgagaa	14	11	8	8	1	2	1	1	1	1	1	3	4	3	2	2	2	1	0	2	2	7	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:67218723A>G	uc010dfa.1	-	5	1029	c.150T>C	c.(148-150)TTT>TTC	p.F50F	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfc.1_5'UTR	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	50					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					ATCCCCAATTAAACTTCAGGC	0.333													91	106					0	0	0	0	G	67218723	G	G	67218723	2	3	50	1	0	0	0	0	0	0	0	1	29	359	13	5		5	ABCA10	17	67218723	Silent	SNP	A	TCGA-CN-4739-01A-02D-1512-08	6459093	67218723	13976487	196	10075											
CDC42EP4	23580	broad.mit.edu	37	chr17	71282368	71282368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgctcccccctggtcaccGactgtgaccgcttgctgccc	3	8	9	21	3	1	1	1	1	0	0	2	2	2	1	7	1	2	3	7	1	0	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:71282368G>A	uc002jjn.2	-	2	419	c.272C>T	c.(271-273)TCG>TTG	p.S91L	CDC42EP4_uc002jjo.2_Missense_Mutation_p.S91L|CDC42EP4_uc002jjp.1_Intron	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	91					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			CCTGGTCACCGACTGTGACCG	0.632													23	57					0	0	0	0	A	71282368	A	A	71282368	3	1	50	1	0	0	0	0	1	0	0	0	3093	1059	37	1	802	1	CDC42EP4	17	71282368	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	4063645	71282368	9912842	197	10076											
ST6GALNAC2	10610	broad.mit.edu	37	chr17	74569350	74569350	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgcctccgttgcccaccaCggcacaccggatacactttg	9	8	8	16	3	0	0	0	0	0	0	1	1	1	1	5	2	3	2	5	2	2	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:74569350C>T	uc002jsg.3	-	4	712	c.457G>A	c.(457-459)GTG>ATG	p.V153M		NM_006456	NP_006447	Q9UJ37	SIA7B_HUMAN	sialyltransferase 7B	153	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity				0						TTGCCCACCACGGCACACCGG	0.607													5	26					0	0	0	0	T	74569350	T	T	74569350	3	4	50	1	0	0	0	0	1	0	0	0	15290	536	19	1	691	1	ST6GALNAC2	17	74569350	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	3286982	74569350	6625860	198	10077											
CARD14	79092	broad.mit.edu	37	chr17	78175565	78175565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgattacgaagcctcagagcCcttgttcaaggcagtcctgg	9	10	11	11	1	2	2	2	1	0	1	3	3	3	2	3	2	3	2	3	2	3	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr17:78175565C>T	uc002jxw.1	+	14	2069	c.1874C>T	c.(1873-1875)CCC>CTC	p.P625L	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.P625L|CARD14_uc010wud.1_Intron	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	625	PDZ.			DYEASEPLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTD GYKRLLQDLEAK -> SRARPLLSPGLLMGTVAAGGVTQAD FTSPRRCRSTLGWASALSWADVKRSAHL (in Ref. 4; AAH01326).	activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GCCTCAGAGCCCTTGTTCAAG	0.597													4	104					0	0	0	0	T	78175565	T	T	78175565	3	4	50	1	0	0	0	0	1	0	0	0	2658	623	22	4	2089	4	CARD14	17	78175565	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	3606215	78175565	3019645	199	10078											
TUBB6	84617	broad.mit.edu	37	chr18	12325643	12325643	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagtaccgggccctgacCgtgcccgagctcacccagca	8	4	11	18	3	1	1	1	1	0	0	1	2	1	1	5	1	5	4	5	1	1	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr18:12325643C>A	uc002kqw.2	+	4	900	c.855C>A	c.(853-855)ACC>ACA	p.T285T	TUBB6_uc002kqv.2_Silent_p.T213T|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Silent_p.T248T|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	285					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		GGGCCCTGACCGTGCCCGAGC	0.687													13	38					0.000132079	0.000141315	1	0	A	12325643	A	A	12325643	2	1	50	1	0	0	0	0	0	0	0	1	16828	639	23	3		3	TUBB6	18	12325643	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08		12325643	65751605	200	10079											
DTNA	1837	broad.mit.edu	37	chr18	32345948	32345948	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaagatctggatcgcatcCgactctccacctacagaaca	12	8	6	15	2	3	2	1	0	2	2	6	4	4	3	3	1	2	1	3	1	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr18:32345948C>T	uc010dmn.1	+	2	92	c.91C>T	c.(91-93)CGA>TGA	p.R31*	DTNA_uc002kxu.2_Nonsense_Mutation_p.R31*|DTNA_uc010xbx.1_Nonsense_Mutation_p.R31*|DTNA_uc002kxv.3_Nonsense_Mutation_p.R31*|DTNA_uc002kxw.2_Nonsense_Mutation_p.R31*|DTNA_uc002kxx.2_Nonsense_Mutation_p.R31*|DTNA_uc010dmj.2_Nonsense_Mutation_p.R31*|DTNA_uc002kxz.2_Nonsense_Mutation_p.R31*|DTNA_uc002kxy.2_Nonsense_Mutation_p.R31*|DTNA_uc010dmk.1_RNA|DTNA_uc010dml.2_Nonsense_Mutation_p.R31*|DTNA_uc002kyb.3_Nonsense_Mutation_p.R31*|DTNA_uc010dmm.2_Nonsense_Mutation_p.R31*	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	31	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						GGATCGCATCCGACTCTCCAC	0.408													8	77					0	0	0	0	T	32345948	T	T	32345948	4	4	50	1	0	0	0	0	0	1	0	0	4810	644	23	1	97	1	DTNA	18	32345948	Nonsense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	20020305	32345948	45731300	201	10080											
ABCA7	10347	broad.mit.edu	37	chr19	1042123	1042123	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggggccagtgcccacaggacGctggctggcctagggaagct	7	5	17	12	1	0	0	0	0	0	0	0	2	0	2	3	6	2	3	3	6	2	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:1042123G>T	uc002lqw.3	+	5	594	c.363G>T	c.(361-363)ACG>ACT	p.T121T	ABCA7_uc010dsb.1_5'Flank|ABCA7_uc010dsa.2_Silent_p.T121T	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	121	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCACAGGACGCTGGCTGGCC	0.716													4	12					0.000602214	0.00063544	1	0	T	1042123	T	T	1042123	2	4	50	1	0	0	0	0	0	0	0	1	37	1074	38	3		3	ABCA7	19	1042123	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08		1042123	58086860	202	10081											
DIRAS1	148252	broad.mit.edu	37	chr19	2717400	2717400	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cactcctgggccaccgcctgCgcctcgcgcgtgtccacctc	3	7	10	21	5	0	0	0	0	0	0	4	0	2	0	7	1	1	0	7	1	0	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:2717400C>G	uc002lwf.3	-	2	563	c.405G>C	c.(403-405)GCG>GCC	p.A135A		NM_145173	NP_660156	O95057	DIRA1_HUMAN	DIRAS family, GTP-binding RAS-like 1	135					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCGCCTGCGCCTCGCGCG	0.617													25	76					0	0	0	0	G	2717400	G	G	2717400	2	3	50	1	0	0	0	0	0	0	0	1	4552	755	27	3		3	DIRAS1	19	2717400	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	1675277	2717400	56411583	203	10082											
TLE2	7089	broad.mit.edu	37	chr19	3009612	3009612	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctgacgtaggagctgggCacggagaggtctccgttgag	8	7	18	8	3	1	3	0	2	1	1	2	5	1	4	1	5	1	5	1	5	1	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:3009612C>A	uc002lww.2	-	13	1364	c.1101G>T	c.(1099-1101)GTG>GTT	p.V367V	TLE2_uc010xhb.1_Intron|TLE2_uc010dth.2_Silent_p.V368V|TLE2_uc010xhc.1_Silent_p.V245V|TLE2_uc010dti.2_Silent_p.V381V|TLE2_uc010xhd.1_Silent_p.V275V	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	367	Pro/Ser-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGAGCTGGGCACGGAGAGGT	0.662													3	23					0.00909568	0.00940297	1	0	A	3009612	A	A	3009612	2	1	50	1	0	0	0	0	0	0	0	1	16005	697	25	4		4	TLE2	19	3009612	Silent	SNP	C	TCGA-CN-4739-01A-02D-1512-08	292212	3009612	56119371	204	10083											
GIPC3	126326	broad.mit.edu	37	chr19	3589862	3589862	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggaggaggcatctcggaagGttgatgacctgctggaaagc	11	7	16	7	1	1	2	0	2	1	0	2	6	1	6	1	6	2	3	1	6	2	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:3589862G>T	uc002lyd.3	+	5	766	c.739G>T	c.(739-741)GTT>TTT	p.V247F		NM_133261	NP_573568	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	247										breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCTCGGAAGGTTGATGACCT	0.652													35	189					2.95478e-19	3.81503e-19	1	0	T	3589862	T	T	3589862	3	4	50	1	0	0	0	0	1	0	0	0	6431	1261	44	4	757	4	GIPC3	19	3589862	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	580250	3589862	55539121	205	10084											
TMIGD2	126259	broad.mit.edu	37	chr19	4292863	4292863	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccccggggccggtataggacGttgctgtagaatgcatttcc	7	10	13	11	3	0	1	0	0	0	1	1	2	1	2	4	4	2	5	4	4	4	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:4292863G>A	uc002lzx.1	-	5	628	c.582C>T	c.(580-582)AAC>AAT	p.N194N	TMIGD2_uc010dtv.1_Silent_p.N190N	NM_144615	NP_653216	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain	194	Cytoplasmic (Potential).					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTATAGGACGTTGCTGTAGA	0.552													24	134					0	0	0	0	A	4292863	A	A	4292863	2	1	50	1	0	0	0	0	0	0	0	1	16297	1136	40	1		1	TMIGD2	19	4292863	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	703001	4292863	54836120	206	10085											
MUC16	94025	broad.mit.edu	37	chr19	9062982	9062982	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaggaggtgacttctgtcCtggagacttcagcagtggca	9	10	14	8	0	2	3	1	1	1	2	3	5	3	4	1	4	1	2	1	4	1	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:9062982C>A	uc002mkp.2	-	3	24668	c.24464G>T	c.(24463-24465)AGG>ATG	p.R8155M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8157	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACTTCTGTCCTGGAGACTTC	0.547													30	140					2.46105e-21	3.2046e-21	1	0	A	9062982	A	A	9062982	3	1	50	1	0	0	0	0	1	0	0	0	10026	681	24	4	19387	4	MUC16	19	9062982	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	4770119	9062982	50066001	207	10086											
ZNF440	126070	broad.mit.edu	37	chr19	11943025	11943025	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttatgaatgtaagatatGtggaaaagacttttgttctg	13	15	9	4	0	1	3	0	1	1	2	1	4	1	4	1	1	0	2	1	1	6	6			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:11943025G>A	uc002msp.1	+	4	1190	c.1034G>A	c.(1033-1035)TGT>TAT	p.C345Y		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	345	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTAAGATATGTGGAAAAGAC	0.363													17	70					0	0	0	0	A	11943025	A	A	11943025	3	1	50	1	0	0	0	0	1	0	0	0	17980	1377	48	4	1048	4	ZNF440	19	11943025	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	2880043	11943025	47185958	208	10087											
ZNF536	9745	broad.mit.edu	37	chr19	30935280	30935280	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggaggacgcggtggccccgGcggcgggcttccgctgtacc	4	5	18	14	6	0	0	0	0	0	0	1	2	1	2	4	7	1	3	4	7	1	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:30935280G>C	uc002nsu.1	+	2	949	c.811G>C	c.(811-813)GCG>CCG	p.A271P	ZNF536_uc010edd.1_Missense_Mutation_p.A271P	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGTGGCCCCGGCGGCGGGCTT	0.672													7	23					0	0	0	0	C	30935280	C	C	30935280	3	2	50	1	0	0	0	0	1	0	0	0	18041	1203	42	4	813	4	ZNF536	19	30935280	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	18992255	30935280	28193703	209	10088											
ZNF30	90075	broad.mit.edu	37	chr19	35434153	35434153	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttggaagatgatacaatcGgctgtaaagaaatgcccacc	15	8	10	8	1	0	3	0	1	0	2	1	4	0	4	2	2	2	3	2	2	6	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:35434153G>C	uc010edp.1	+	5	661	c.283G>C	c.(283-285)GGC>CGC	p.G95R	ZNF30_uc002nxf.2_Missense_Mutation_p.G14R|ZNF30_uc010edq.1_Missense_Mutation_p.G96R|ZNF30_uc010edr.1_Missense_Mutation_p.G96R	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		TGATACAATCGGCTGTAAAGA	0.308													6	20					0	0	0	0	C	35434153	C	C	35434153	3	2	50	1	0	0	0	0	1	0	0	0	17897	1116	39	3	300	3	ZNF30	19	35434153	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	4498873	35434153	23694830	210	10089											
RYR1	6261	broad.mit.edu	37	chr19	38976768	38976768	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggtgcgcgacggtgggcagCacgctcgcgaccccgtcggg	4	4	18	15	9	0	0	0	0	0	0	2	2	0	0	2	4	2	3	2	4	0	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:38976768C>T	uc002oit.2	+	34	5603	c.5473C>T	c.(5473-5475)CAC>TAC	p.H1825Y	RYR1_uc002oiu.2_Missense_Mutation_p.H1825Y	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1825	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGGTGGGCAGCACGCTCGCGA	0.687													63	168					0	0	0	0	T	38976768	T	T	38976768	3	4	50	1	0	0	0	0	1	0	0	0	13833	710	25	4	5607	4	RYR1	19	38976768	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	3542615	38976768	20152215	211	10090											
ACTN4	81	broad.mit.edu	37	chr19	39215092	39215092	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcagcagctggtgccaaaaCgggaccatgccctcctggag	9	6	13	13	1	0	0	0	0	0	0	1	2	1	2	4	3	6	3	4	3	2	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:39215092C>T	uc002oja.1	+	16	1956	c.1897C>T	c.(1897-1899)CGG>TGG	p.R633W	ACTN4_uc002ojb.1_5'Flank	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	633	Spectrin 3.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGTGCCAAAACGGGACCATGC	0.687													7	33					0	0	0	0	T	39215092	T	T	39215092	3	4	50	1	0	0	0	0	1	0	0	0	207	527	19	1	1959	1	ACTN4	19	39215092	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	238324	39215092	19913891	212	10091											
GRIN2D	2906	broad.mit.edu	37	chr19	48908443	48908443	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctgccgggctgtttgcAgtgcgctcggctggctggcg	1	10	17	13	4	0	0	0	0	0	0	1	0	0	0	2	4	4	6	2	4	0	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:48908443A>C	uc002pjc.3	+	3	1006	c.918A>C	c.(916-918)GCA>GCC	p.A306A		NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	306	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GGCTGTTTGCAGTGCGCTCGG	0.716													3	13					0	0	0	0	C	48908443	C	C	48908443	2	2	50	1	0	0	0	0	0	0	0	1	6821	175	7	5		5	GRIN2D	19	48908443	Silent	SNP	A	TCGA-CN-4739-01A-02D-1512-08	9693351	48908443	10220540	213	10092											
PLEKHA4	57664	broad.mit.edu	37	chr19	49340739	49340739	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctggggggaggggtctccTggcgcgtggggtccgaagga	5	7	21	8	3	2	0	0	0	2	0	4	3	3	2	2	9	0	0	2	9	1	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:49340739T>G	uc002pkx.2	-	20	2698	c.2147A>C	c.(2146-2148)CAG>CCG	p.Q716P	HSD17B14_uc002pkv.1_5'Flank|HSD17B14_uc010emk.1_5'Flank|PLEKHA4_uc002pkw.1_3'UTR|PLEKHA4_uc010eml.2_3'UTR	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	716						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		AGGGGTCTCCTGGCGCGTGGG	0.667													27	80					0	0	0	0	G	49340739	G	G	49340739	3	3	50	1	0	0	0	0	1	0	0	0	12113	1580	55	5	196	5	PLEKHA4	19	49340739	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	432296	49340739	9788244	214	10093											
LRRC4B	94030	broad.mit.edu	37	chr19	51021898	51021898	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcgcatagcaggtgaaatGcgactggtccagctccccaa	10	6	13	12	2	0	1	0	1	0	0	2	2	2	1	3	3	3	3	3	3	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:51021898G>T	uc002pss.2	-	3	1209	c.1072C>A	c.(1072-1074)CAT>AAT	p.H358N		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	358	LRRCT.|Extracellular (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		CAGGTGAAATGCGACTGGTCC	0.667													16	51					2.48551e-13	3.05448e-13	1	0	T	51021898	T	T	51021898	3	4	50	1	0	0	0	0	1	0	0	0	9057	1319	46	4	1073	4	LRRC4B	19	51021898	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	1681159	51021898	8107085	215	10094											
FPR1	2357	broad.mit.edu	37	chr19	52249531	52249531	+	Frame_Shift_Del	DEL	G	-	-																															acaaaggagaggacccgtaaGggacgactggacttaatcaa																										TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:52249531delG	uc002pxq.2	-	2	812	c.717delC	c.(715-717)CCCfs	p.P239fs		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	239	Cytoplasmic (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GGACCCGTAAGGGACGACTGG	0.512													---	---	---								-	52249531	-	-	52249531	7	5	50	1	0	1	0	1	0	0	0	0	6072	987	35	0	339	0	FPR1	19	52249531	Frame_Shift_Del	DEL	G	TCGA-CN-4739-01A-02D-1512-08	1227633	52249531	6879452	216	10095											
PPP1R12C	54776	broad.mit.edu	37	chr19	55606107	55606107	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgctggggattcaggctccGgaatcctggagggaggcgag	7	7	18	9	3	1	0	1	0	0	0	4	5	3	4	2	7	0	2	2	7	1	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:55606107G>A	uc002qix.2	-	12	1530	c.1514C>T	c.(1513-1515)CCG>CTG	p.P505L	PPP1R12C_uc010yfs.1_Missense_Mutation_p.P431L|PPP1R12C_uc002qiy.2_Missense_Mutation_p.P504L	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	505	Pro-rich.					cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		TTCAGGCTCCGGAATCCTGGA	0.547													8	11					0	0	0	0	A	55606107	A	A	55606107	3	1	50	1	0	0	0	0	1	0	0	0	12416	1116	39	1	878	1	PPP1R12C	19	55606107	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	3356576	55606107	3522876	217	10096											
NLRP8	126205	broad.mit.edu	37	chr19	56466303	56466303	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggctttgaggagctcacatcTaccctcattgacagactgga	10	10	10	11	0	3	3	2	2	1	1	3	5	3	5	1	3	2	2	1	3	1	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:56466303T>A	uc002qmh.2	+	3	950	c.879T>A	c.(877-879)TCT>TCA	p.S293S	NLRP8_uc010etg.2_Silent_p.S293S	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	293	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AGCTCACATCTACCCTCATTG	0.507													52	229					0	0	0	0	A	56466303	A	A	56466303	2	1	50	1	0	0	0	0	0	0	0	1	10537	1509	53	5		5	NLRP8	19	56466303	Silent	SNP	T	TCGA-CN-4739-01A-02D-1512-08	860196	56466303	2662680	218	10097											
NLRP5	126206	broad.mit.edu	37	chr19	56552287	56552287	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggggctctcttcttgcaGactggaggactgtggcatca	6	12	13	10	0	4	1	1	0	3	1	5	3	4	3	0	5	1	3	0	5	0	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:56552287G>T	uc002qmj.2	+	11	2787	c.2787_splice	c.e11-1	p.I929_splice	NLRP5_uc002qmi.2_Splice_Site_p.I910_splice	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5							mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TCTTCTTGCAGACTGGAGGAC	0.542													14	50					1.49906e-05	1.63826e-05	1	0	T	56552287	T	T	56552287	5	4	50	1	0	0	0	0	0	0	1	0	10534	956	33	2	2828	2	NLRP5	19	56552287	Splice_Site	SNP	G	TCGA-CN-4739-01A-02D-1512-08	85984	56552287	2576696	219	10098											
ZNF135	7694	broad.mit.edu	37	chr19	58579484	58579484	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcagcatcagaggatccaCacaggagagaaaccctatga	16	6	9	10	0	2	3	2	1	0	2	3	6	3	5	2	2	2	1	2	2	2	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr19:58579484C>A	uc010yhq.1	+	5	1764	c.1668C>A	c.(1666-1668)CAC>CAA	p.H556Q	ZNF135_uc002qre.2_Missense_Mutation_p.H544Q|ZNF135_uc002qrd.1_Intron|ZNF135_uc002qrf.2_Missense_Mutation_p.H502Q|ZNF135_uc002qrg.2_Missense_Mutation_p.H514Q|ZNF135_uc010yhr.1_Missense_Mutation_p.H365Q	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	556					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		AGAGGATCCACACAGGAGAGA	0.532													22	79					2.89027e-11	3.46832e-11	1	0	A	58579484	A	A	58579484	3	1	50	1	0	0	0	0	1	0	0	0	17792	477	17	4	1835	4	ZNF135	19	58579484	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	2027197	58579484	549499	220	10099											
CSNK2A1	1457	broad.mit.edu	37	chr20	485836	485836	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacttcactgtatttacctcGgcctaattttcgaaccagct	9	15	5	12	2	1	0	1	0	0	0	3	1	1	0	3	1	4	2	3	1	5	8			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr20:485836G>A	uc002wdw.1	-	4	532	c.139C>T	c.(139-141)CGA>TGA	p.R47*	CSNK2A1_uc002wdx.1_Nonsense_Mutation_p.R47*|CSNK2A1_uc002wdy.1_5'UTR	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	47	ATP (By similarity).|Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			TATTTACCTCGGCCTAATTTT	0.343													17	67					0	0	0	0	A	485836	A	A	485836	4	1	50	1	0	0	0	0	0	1	0	0	3974	1124	39	1	1080	1	CSNK2A1	20	485836	Nonsense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08		485836	62539684	221	10100											
SLC4A11	83959	broad.mit.edu	37	chr20	3209785	3209785	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcggccaccaagttctgctcGatgaagaagagcatggacag	12	6	13	10	2	1	3	0	1	1	2	2	5	1	4	2	2	2	3	2	2	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr20:3209785G>A	uc002wig.2	-	15	2070	c.2022C>T	c.(2020-2022)ATC>ATT	p.I674I	SLC4A11_uc010zqe.1_Silent_p.I701I|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Silent_p.I658I	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	674	Helical; (Potential).|Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						AGTTCTGCTCGATGAAGAAGA	0.667													12	77					0	0	0	0	A	3209785	A	A	3209785	2	1	50	1	0	0	0	0	0	0	0	1	14716	1048	37	1		1	SLC4A11	20	3209785	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	2723949	3209785	59815735	222	10101											
PLCB4	5332	broad.mit.edu	37	chr20	9417742	9417742	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgacccctcagagtagcTctgagctcagaccaaccacc	11	7	8	15	0	3	4	2	2	1	2	3	4	3	4	5	0	3	3	5	0	2	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr20:9417742T>A	uc002wnf.2	+	28	2807	c.2671T>A	c.(2671-2673)TCT>ACT	p.S891T	PLCB4_uc010gbw.1_Missense_Mutation_p.S891T|PLCB4_uc010gbx.2_Missense_Mutation_p.S903T|PLCB4_uc002wne.2_Missense_Mutation_p.S891T|PLCB4_uc002wnh.2_Missense_Mutation_p.S738T	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	891					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TCAGAGTAGCTCTGAGCTCAG	0.542													7	64					0	0	0	0	A	9417742	A	A	9417742	3	1	50	1	0	0	0	0	1	0	0	0	12085	1551	54	5	2813	5	PLCB4	20	9417742	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	6207957	9417742	53607778	223	10102											
XKR7	343702	broad.mit.edu	37	chr20	30584546	30584546	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggtgcgtcatgaccttctgGgtcatccaaggggagacgga	8	9	15	9	2	3	2	2	1	1	1	4	4	4	3	2	5	1	0	2	5	1	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr20:30584546G>T	uc002wxe.2	+	3	1200	c.1026G>T	c.(1024-1026)TGG>TGT	p.W342C		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	342						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TGACCTTCTGGGTCATCCAAG	0.562													7	68					8.12818e-05	8.7271e-05	1	0	T	30584546	T	T	30584546	3	4	50	1	0	0	0	0	1	0	0	0	17504	1241	43	4	1036	4	XKR7	20	30584546	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	21166804	30584546	32440974	224	10103											
MC3R	4159	broad.mit.edu	37	chr20	54824142	54824142	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctttctctgcagcctggcGgtggccgacatgctggtaag	5	12	13	11	2	2	0	0	0	2	0	3	1	2	0	2	4	3	3	2	4	1	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr20:54824142G>A	uc002xxb.2	+	1	355	c.243G>A	c.(241-243)GCG>GCA	p.A81A		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	118	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			GCAGCCTGGCGGTGGCCGACA	0.567													6	85					0	0	0	0	A	54824142	A	A	54824142	2	1	50	1	0	0	0	0	0	0	0	1	9418	1103	39	1		1	MC3R	20	54824142	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	24239596	54824142	8201378	225	10104											
PRIC285	85441	broad.mit.edu	37	chr20	62197377	62197377	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgccgctccacgcactcaCggatgaagctctcccagagc	8	7	10	16	3	2	2	1	1	1	1	4	3	3	3	3	1	3	3	3	1	1	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr20:62197377C>T	uc002yfm.2	-	9	3690	c.2798G>A	c.(2797-2799)CGT>CAT	p.R933H	PRIC285_uc002yfl.1_Missense_Mutation_p.R364H	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	933					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CACGCACTCACGGATGAAGCT	0.701													4	12					0	0	0	0	T	62197377	T	T	62197377	3	4	50	1	0	0	0	0	1	0	0	0	12547	536	19	1	5199	1	PRIC285	20	62197377	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	7373235	62197377	828143	226	10105											
ERG	2078	broad.mit.edu	37	chr21	39755448	39755448	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaactggaagatgtcacGgggagggctggagggtgggg	12	5	20	4	1	1	1	1	0	0	1	1	4	1	4	0	8	1	1	0	8	4	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr21:39755448G>A	uc010gnw.2	-	12	1633	c.1338C>T	c.(1336-1338)CCC>CCT	p.P446P	ERG_uc002yxa.2_Silent_p.P439P|ERG_uc011aek.1_Silent_p.P347P|ERG_uc010gnv.2_Silent_p.P323P|ERG_uc010gnx.2_Silent_p.P422P|ERG_uc011ael.1_Silent_p.P446P|ERG_uc002yxb.2_Silent_p.P422P	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	446					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				AAGATGTCACGGGGAGGGCTG	0.552													18	40					0	0	0	0	A	39755448	A	A	39755448	2	1	50	1	0	0	0	0	0	0	0	1	5246	1103	39	1		1	ERG	21	39755448	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08		39755448	8374447	227	10106											
CECR5	27440	broad.mit.edu	37	chr22	17619593	17619593	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccgtcactttctggtaaatgGtttccaggcacagcagaaag	11	10	10	10	1	2	1	1	0	1	1	3	1	3	1	2	3	1	4	2	3	3	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr22:17619593G>A	uc002zmf.2	-	7	810	c.782C>T	c.(781-783)ACC>ATC	p.T261I	CECR5_uc002zmd.2_Missense_Mutation_p.T72I|CECR5_uc002zme.2_Missense_Mutation_p.T53I|CECR5_uc002zmg.2_Intron|CECR5_uc002zmh.2_Missense_Mutation_p.T231I	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	261							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				CTGGTAAATGGTTTCCAGGCA	0.542													77	218					0	0	0	0	A	17619593	A	A	17619593	3	1	50	1	0	0	0	0	1	0	0	0	3222	1261	44	4	497	4	CECR5	22	17619593	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08		17619593	33684973	228	10107											
DGCR14	8220	broad.mit.edu	37	chr22	19121731	19121731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaagaagtccgaagctttgCgccgggcagggagctgcagc	11	5	15	10	3	0	1	0	0	0	1	1	3	1	2	2	2	5	4	2	2	4	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr22:19121731C>T	uc002zou.2	-	10	1446	c.1409G>A	c.(1408-1410)CGC>CAC	p.R470H	DGCR14_uc002zot.2_Missense_Mutation_p.R391H|DGCR14_uc002zov.2_RNA	NM_022719	NP_073210	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region protein 14	470					nervous system development	catalytic step 2 spliceosome				ovary(1)	1	Colorectal(54;0.0993)					CGAAGCTTTGCGCCGGGCAGG	0.647													3	65					0	0	0	0	T	19121731	T	T	19121731	3	4	50	1	0	0	0	0	1	0	0	0	4482	768	27	1	25	1	DGCR14	22	19121731	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	1502138	19121731	32182835	229	10108											
CCDC116	164592	broad.mit.edu	37	chr22	21989393	21989393	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcccacctcagatctgccGcctctgggctctgagccagc	6	7	11	17	1	4	2	1	1	3	1	4	3	4	2	5	1	4	1	5	1	0	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr22:21989393G>A	uc002zve.2	+	4	1134	c.1041G>A	c.(1039-1041)CCG>CCA	p.P347P	CCDC116_uc011aih.1_Silent_p.P347P	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	347										ovary(1)|skin(1)	2	Colorectal(54;0.105)					CAGATCTGCCGCCTCTGGGCT	0.642													14	46					0	0	0	0	A	21989393	A	A	21989393	2	1	50	1	0	0	0	0	0	0	0	1	2765	1074	38	1		1	CCDC116	22	21989393	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	2867662	21989393	29315173	230	10109											
ELFN2	114794	broad.mit.edu	37	chr22	37769205	37769205	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaccttcttgcgcagggcGtgaccggcggccatgtacac	6	8	14	13	4	1	1	0	1	1	0	1	2	1	2	3	4	2	2	3	4	1	3	rs148494870	by1000genomes	TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chr22:37769205G>A	uc003asq.3	-	3	3156	c.2370C>T	c.(2368-2370)CAC>CAT	p.H790H		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	790	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					TGCGCAGGGCGTGACCGGCGG	0.627													10	118					0	0	0	0	A	37769205	A	A	37769205	2	1	50	1	0	0	0	0	0	0	0	1	5082	1136	40	1		1	ELFN2	22	37769205	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	15779812	37769205	13535361	231	10110											
SH3KBP1	30011	broad.mit.edu	37	chrX	19725001	19725001	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccggccaggtcgcttacctCtcctaccacctctatgatgt	6	11	7	17	2	2	1	0	1	2	0	4	1	2	1	6	2	2	1	6	2	3	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:19725001C>G	uc004czm.2	-	4	704	c.388G>C	c.(388-390)GAG>CAG	p.E130Q	SH3KBP1_uc004czl.2_Missense_Mutation_p.E93Q	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	130	SH3 2.				apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						TCGCTTACCTCTCCTACCACC	0.582													17	25					0	0	0	0	G	19725001	G	G	19725001	3	3	50	1	0	0	0	0	1	0	0	0	14320	922	32	2	1685	2	SH3KBP1	23	19725001	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08		19725001	135545559	232	10111											
FAM47B	170062	broad.mit.edu	37	chrX	34962575	34962575	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcattcttatagtgcacagCgtgggaggataaggtatgga	11	10	14	6	2	1	0	0	0	1	0	1	3	1	3	0	4	2	3	0	4	4	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:34962575C>A	uc004ddi.1	+	1	1645	c.1627C>A	c.(1627-1629)CGT>AGT	p.R543S		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	543										ovary(3)|breast(1)	4						TAGTGCACAGCGTGGGAGGAT	0.498													45	53					8.05343e-35	1.07146e-34	1	0	A	34962575	A	A	34962575	3	1	50	1	0	0	0	0	1	0	0	0	5602	768	27	3	1629	3	FAM47B	23	34962575	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	15237574	34962575	120307985	233	10112											
PRRG1	5638	broad.mit.edu	37	chrX	37285132	37285132	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccaattccatattaaaacGctacccaagagctaatgggt	15	9	7	10	1	0	1	0	0	0	1	1	1	1	1	3	1	4	2	3	1	7	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:37285132G>A	uc004ddn.2	+	4	303	c.50G>A	c.(49-51)CGC>CAC	p.R17H	PRRG1_uc004ddo.2_Missense_Mutation_p.R17H|PRRG1_uc010ngx.1_RNA	NM_000950	NP_000941	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	17						extracellular region|integral to plasma membrane	calcium ion binding			ovary(1)|breast(1)	2						ATATTAAAACGCTACCCAAGA	0.358													4	51					0	0	0	0	A	37285132	A	A	37285132	3	1	50	1	0	0	0	0	1	0	0	0	12667	1087	38	1	56	1	PRRG1	23	37285132	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	2322557	37285132	117985428	234	10113											
FOXP3	50943	broad.mit.edu	37	chrX	49107877	49107877	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagctcatccacggtccacAcagcccccttctcgctctcc	6	8	5	22	2	3	0	1	0	2	0	7	0	5	0	6	1	2	2	6	1	0	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:49107877A>C	uc004dnf.3	-	12	1402	c.1214T>G	c.(1213-1215)GTG>GGG	p.V405G	FOXP3_uc011mnb.1_Missense_Mutation_p.V428G|FOXP3_uc011mnc.1_Missense_Mutation_p.V378G|FOXP3_uc004dne.3_Missense_Mutation_p.V370G|FOXP3_uc010niq.1_Missense_Mutation_p.V430G	NM_014009	NP_054728	Q9BZS1	FOXP3_HUMAN	forkhead box P3 isoform a	405	Fork-head.				B cell homeostasis|cerebellum development|chromatin remodeling|embryo development|myeloid cell homeostasis|negative regulation of activated T cell proliferation|negative regulation of chronic inflammatory response|negative regulation of CREB transcription factor activity|negative regulation of cytokine secretion|negative regulation of histone acetylation|negative regulation of histone deacetylation|negative regulation of interferon-gamma biosynthetic process|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-2 biosynthetic process|negative regulation of interleukin-2 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of interleukin-6 production|negative regulation of isotype switching to IgE isotypes|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell cytokine production|negative regulation of tumor necrosis factor production|pattern specification process|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|positive regulation of histone acetylation|positive regulation of immature T cell proliferation in thymus|positive regulation of peripheral T cell tolerance induction|positive regulation of T cell anergy|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor-beta1 production|post-embryonic development|regulation of isotype switching to IgG isotypes|response to virus|T cell homeostasis|T cell receptor signaling pathway|tolerance induction to self antigen	cytoplasm|cytoplasm|nucleus|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|histone acetyltransferase binding|histone deacetylase binding|NF-kappaB binding|NFAT protein binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription corepressor activity|zinc ion binding				0	Ovarian(276;0.236)					CACGGTCCACACAGCCCCCTT	0.617													4	31					0	0	0	0	C	49107877	C	C	49107877	3	2	50	1	0	0	0	0	1	0	0	0	6062	159	6	5	85	5	FOXP3	23	49107877	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	11822745	49107877	106162683	235	10114											
KIF4A	24137	broad.mit.edu	37	chrX	69563610	69563610	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagagctcaggcagcatgcgGcgtaagttgcccaccagata	12	6	12	11	2	1	2	1	0	0	2	1	2	1	2	2	2	4	5	2	2	3	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:69563610G>T	uc004dyg.2	+	12	1451	c.1324G>T	c.(1324-1326)GCC>TCC	p.A442S	KIF4A_uc010nkw.2_Missense_Mutation_p.A442S|KIF4A_uc004dyf.1_Missense_Mutation_p.A442S	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	442	Potential.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						GCAGCATGCGGCGTAAGTTGC	0.468													15	21					4.14922e-12	5.03834e-12	1	0	T	69563610	T	T	69563610	3	4	50	1	0	0	0	0	1	0	0	0	8342	1217	42	4	1366	4	KIF4A	23	69563610	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	20455733	69563610	85706950	236	10115											
TAF1	6872	broad.mit.edu	37	chrX	70618460	70618460	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgaacaacatcgggaagAgatgcgaaaagaacggcgga	17	4	14	6	4	0	4	0	2	0	2	1	8	0	6	0	3	4	0	0	3	6	0			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:70618460A>G	uc004dzu.3	+	24	3707	c.3656A>G	c.(3655-3657)GAG>GGG	p.E1219G	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.E1240G|TAF1_uc004dzv.3_Missense_Mutation_p.E393G	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1219	HMG box.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				CATCGGGAAGAGATGCGAAAA	0.468													6	39					0	0	0	0	G	70618460	G	G	70618460	3	3	50	1	0	0	0	0	1	0	0	0	15579	304	11	5	3813	5	TAF1	23	70618460	Missense_Mutation	SNP	A	TCGA-CN-4739-01A-02D-1512-08	1054850	70618460	84652100	237	10116											
ITM2A	9452	broad.mit.edu	37	chrX	78616844	78616844	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccagcaagaggtctctgcGacgaaggcggaaggactttc	11	6	13	11	3	1	1	0	0	1	1	3	5	1	3	1	4	2	1	1	4	3	1			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:78616844G>T	uc004edh.2	-	5	1020	c.685C>A	c.(685-687)CGC>AGC	p.R229S	ITM2A_uc011mqr.1_Missense_Mutation_p.R185S	NM_004867	NP_004858	O43736	ITM2A_HUMAN	integral membrane protein 2A	229						integral to membrane	protein binding			lung(2)	2						AGGTCTCTGCGACGAAGGCGG	0.438													31	40					3.90053e-15	4.91177e-15	1	0	T	78616844	T	T	78616844	3	4	50	1	0	0	0	0	1	0	0	0	7951	1058	37	3	114	3	ITM2A	23	78616844	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	7998384	78616844	76653716	238	10117											
CPXCR1	53336	broad.mit.edu	37	chrX	88009098	88009098	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacactaaagggaaatgtaGattccgtgctattgtgaggt	12	12	12	5	1	0	3	0	2	0	1	1	4	1	4	1	2	1	2	1	2	5	5			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:88009098G>T	uc004efd.3	+	3	942	c.683G>T	c.(682-684)AGA>ATA	p.R228I	CPXCR1_uc004efc.3_Missense_Mutation_p.R228I	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	228						intracellular	zinc ion binding			ovary(3)	3						GGGAAATGTAGATTCCGTGCT	0.373													14	16					1.15088e-07	1.30918e-07	1	0	T	88009098	T	T	88009098	3	4	50	1	0	0	0	0	1	0	0	0	3851	942	33	2	685	2	CPXCR1	23	88009098	Missense_Mutation	SNP	G	TCGA-CN-4739-01A-02D-1512-08	9392254	88009098	67261462	239	10118											
PCDH11X	27328	broad.mit.edu	37	chrX	91134064	91134064	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggcccgacactacaaatctgCctctccacagcctgccttcc	8	8	6	19	1	2	0	0	0	2	0	4	1	3	0	6	1	4	0	6	1	2	2			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:91134064C>A	uc004efk.1	+	2	3670	c.2825C>A	c.(2824-2826)GCC>GAC	p.A942D	PCDH11X_uc004efl.1_Missense_Mutation_p.A942D|PCDH11X_uc004efo.1_Missense_Mutation_p.A942D|PCDH11X_uc010nmv.1_Missense_Mutation_p.A942D|PCDH11X_uc004efm.1_Missense_Mutation_p.A942D|PCDH11X_uc004efn.1_Missense_Mutation_p.A942D|PCDH11X_uc004efh.1_Missense_Mutation_p.A942D|PCDH11X_uc004efj.1_Missense_Mutation_p.A942D	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	942	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TACAAATCTGCCTCTCCACAG	0.478													71	87					1.63007e-36	2.17818e-36	1	0	A	91134064	A	A	91134064	3	1	50	1	0	0	0	0	1	0	0	0	11562	739	26	4	2831	4	PCDH11X	23	91134064	Missense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	3124966	91134064	64136496	240	10119											
IGSF1	3547	broad.mit.edu	37	chrX	130416470	130416470	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcatcctaatggaggtcttCcaggtgagaagatagtggca	11	9	14	7	0	1	2	0	1	1	2	3	4	3	3	2	5	0	2	2	5	3	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:130416470C>T	uc004ewd.2	-	7	1432	c.1194G>A	c.(1192-1194)TGG>TGA	p.W398*	IGSF1_uc004ewe.3_Nonsense_Mutation_p.W387*|IGSF1_uc004ewf.2_Nonsense_Mutation_p.W378*	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	398	Ig-like C2-type 4.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						TGGAGGTCTTCCAGGTGAGAA	0.408													41	40					0	0	0	0	T	130416470	T	T	130416470	4	4	50	1	0	0	0	0	0	1	0	0	7635	856	30	2	2887	2	IGSF1	23	130416470	Nonsense_Mutation	SNP	C	TCGA-CN-4739-01A-02D-1512-08	39282406	130416470	24854090	241	10120											
ZNF75D	7626	broad.mit.edu	37	chrX	134421766	134421766	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatcatttccagtgtcatttTttagctttaaccctgttaga	9	18	6	8	0	2	1	2	0	0	1	3	2	3	1	2	0	2	2	2	0	3	7			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:134421766T>A	uc004eyp.2	-	7	3491	c.836A>T	c.(835-837)AAA>ATA	p.K279I	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_Missense_Mutation_p.K58I|ZNF75D_uc004eyo.2_Missense_Mutation_p.K184I	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	279	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGTGTCATTTTTTAGCTTTAA	0.348													46	44					0	0	0	0	A	134421766	A	A	134421766	3	1	50	1	0	0	0	0	1	0	0	0	18201	1841	64	5	700	5	ZNF75D	23	134421766	Missense_Mutation	SNP	T	TCGA-CN-4739-01A-02D-1512-08	4005296	134421766	20848794	242	10121											
CDR1	1038	broad.mit.edu	37	chrX	139866496	139866496	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtcttccaacaaaggtacGtcttccagaaaatccacgtc	13	10	6	12	2	2	1	0	0	2	1	6	1	5	1	3	1	2	1	3	1	5	3			TCGA-CN-4739-01A-02D-1512-08	TCGA-CN-4739-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d6cc6ef-6bb0-44ab-bac1-c8f7198d1d8a	d7ca9d1a-4318-4e16-ab80-1c206f19e33c	g.chrX:139866496G>A	uc004fbg.1	-	1	228	c.36C>T	c.(34-36)GAC>GAT	p.D12D	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	12	23 X 6 AA approximate repeats.|2.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				ACAAAGGTACGTCTTCCAGAA	0.418													57	51					0	0	0	0	A	139866496	A	A	139866496	2	1	50	1	0	0	0	0	0	0	0	1	3186	1136	40	1		1	CDR1	23	139866496	Silent	SNP	G	TCGA-CN-4739-01A-02D-1512-08	5444730	139866496	15404064	243	10122											
AGRN	375790	broad.mit.edu	37	chr1	985677	985677	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcttctcccacctggagctGagaggcctgcacacctttgc	6	9	11	15	0	1	1	0	1	1	1	2	3	1	2	4	3	3	3	4	3	0	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:985677G>C	uc001ack.1	+	28	4994	c.4944G>C	c.(4942-4944)CTG>CTC	p.L1648L		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	1648	Laminin G-like 2.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		ACCTGGAGCTGAGAGGCCTGC	0.687													18	147					0	0	0	0	C	985677	C	C	985677	2	2	51	1	0	0	0	0	0	0	0	1	397	1277	45	2		2	AGRN	1	985677	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08		985677	248264944	1	10123											
DVL1	1855	broad.mit.edu	37	chr1	1277124	1277124	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagggcggtggacgcgctGtctgggggcagccccacatc	5	6	17	13	3	1	1	0	1	1	0	2	2	1	2	2	5	1	2	2	5	0	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:1277124G>A	uc001aer.3	-	5	575	c.528C>T	c.(526-528)GAC>GAT	p.D176D	DVL1_uc002quu.2_5'Flank|DVL1_uc009vka.2_5'Flank|DVL1_uc001aeu.1_5'UTR	NM_004421	NP_004412	O14640	DVL1_HUMAN	dishevelled 1	176					canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TGGACGCGCTGTCTGGGGGCA	0.677													9	39					0	0	0	0	A	1277124	A	A	1277124	2	1	51	1	0	0	0	0	0	0	0	1	4857	1368	48	4		4	DVL1	1	1277124	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	291447	1277124	247973497	2	10124											
TMEM82	388595	broad.mit.edu	37	chr1	16074093	16074093	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accaagccagcccctgccctCggcaccccagtcccagagtt	8	5	8	20	1	0	1	0	0	0	1	2	1	1	1	8	1	3	2	8	1	1	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:16074093C>T	uc001axc.2	+	6	1136	c.998C>T	c.(997-999)TCG>TTG	p.S333L		NM_001013641	NP_001013663	A0PJX8	TMM82_HUMAN	transmembrane protein 82	333						integral to membrane				breast(1)|central_nervous_system(1)	2		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCTGCCCTCGGCACCCCAG	0.607													12	133					0	0	0	0	T	16074093	T	T	16074093	3	4	51	1	0	0	0	0	1	0	0	0	16272	893	31	1	1020	1	TMEM82	1	16074093	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	14796969	16074093	233176528	3	10125											
ECE1	1889	broad.mit.edu	37	chr1	21560052	21560052	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggcctgggggaactcactGatctctgttgggggctttcc	5	11	15	10	0	2	1	1	1	1	0	4	2	3	2	2	5	1	2	2	5	1	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:21560052G>A	uc001bek.2	-	14	1744	c.1669C>T	c.(1669-1671)CAG>TAG	p.Q557*	ECE1_uc001bem.2_Nonsense_Mutation_p.Q541*|ECE1_uc001bej.2_Nonsense_Mutation_p.Q545*|ECE1_uc001bei.2_Nonsense_Mutation_p.Q554*|ECE1_uc010odl.1_Nonsense_Mutation_p.Q557*|ECE1_uc009vqa.1_Nonsense_Mutation_p.Q557*	NM_001397	NP_001388	P42892	ECE1_HUMAN	endothelin converting enzyme 1 isoform 1	557	Extracellular (Potential).				bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			ovary(2)|skin(1)	3		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		GGAACTCACTGATCTCTGTTG	0.577													10	55					0	0	0	0	A	21560052	A	A	21560052	4	1	51	1	0	0	0	0	0	1	0	0	4911	1304	45	2	667	2	ECE1	1	21560052	Nonsense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	5485959	21560052	227690569	4	10126											
S100PBP	64766	broad.mit.edu	37	chr1	33292423	33292423	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtctgtattctctcggatCtcagaccattcagagactcc	9	12	7	13	2	4	2	2	0	3	2	8	4	5	3	2	1	0	1	2	1	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:33292423C>A	uc001bvz.2	+	3	1000	c.723C>A	c.(721-723)ATC>ATA	p.I241I	S100PBP_uc001bwa.1_Silent_p.I241I|S100PBP_uc001bwb.1_Silent_p.I241I|S100PBP_uc001bwc.2_Silent_p.I241I|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	241						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TCTCTCGGATCTCAGACCATT	0.428													16	74					2.23348e-06	2.42145e-06	1	0	A	33292423	A	A	33292423	2	1	51	1	0	0	0	0	0	0	0	1	13856	903	32	2		2	S100PBP	1	33292423	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	11732371	33292423	215958198	5	10127											
MACF1	23499	broad.mit.edu	37	chr1	39945527	39945527	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	catcctaccagagggagcatCccagggaatgacccccttcc	10	6	9	16	0	0	2	0	1	0	1	3	4	3	4	6	2	2	1	6	2	2	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:39945527C>G	uc010oiu.1	+	62	17407	c.17276C>G	c.(17275-17277)TCC>TGC	p.S5759C	MACF1_uc010ois.1_Missense_Mutation_p.S5251C|MACF1_uc001cde.1_Missense_Mutation_p.S128C|MACF1_uc001cdf.1_Missense_Mutation_p.S134C|MACF1_uc001cdg.2_Missense_Mutation_p.S42C|MACF1_uc001cdh.2_Missense_Mutation_p.S42C	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	7209	C-terminal tail (By similarity).				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAGGGAGCATCCCAGGGAATG	0.488													4	93					0	0	0	0	G	39945527	G	G	39945527	3	3	51	1	0	0	0	0	1	0	0	0	9195	855	30	2	22291	2	MACF1	1	39945527	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	6653104	39945527	209305094	6	10128											
RAD54L	8438	broad.mit.edu	37	chr1	46736347	46736347	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagggactgcccatgaattCaagaagcattttgaattgcc	12	12	9	8	0	1	3	1	2	0	1	1	4	1	4	2	1	3	1	2	1	5	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:46736347C>G	uc009vye.2	+	11	1173	c.1059C>G	c.(1057-1059)TTC>TTG	p.F353L	RAD54L_uc001cpl.2_Missense_Mutation_p.F353L|RAD54L_uc001cpm.1_Missense_Mutation_p.F173L	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	353					meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		CCCATGAATTCAAGAAGCATT	0.448								Direct_reversal_of_damage|Homologous_recombination					10	149					0	0	0	0	G	46736347	G	G	46736347	3	3	51	1	0	0	0	0	1	0	0	0	13058	825	29	2	1097	2	RAD54L	1	46736347	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	6790820	46736347	202514274	7	10129											
STIL	6491	broad.mit.edu	37	chr1	47737808	47737808	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccaggggaagactgtgcttCcacagaaaccaactccattt	12	8	9	12	0	0	2	0	0	0	2	2	3	2	3	4	2	3	1	4	2	3	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:47737808C>T	uc001crc.1	-	13	2478	c.2323G>A	c.(2323-2325)GAA>AAA	p.E775K	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.E728K|STIL_uc010omo.1_Missense_Mutation_p.E775K|STIL_uc001crd.1_Missense_Mutation_p.E775K|STIL_uc001cre.1_Missense_Mutation_p.E775K|STIL_uc001crf.1_Missense_Mutation_p.E388K|STIL_uc001crg.1_Missense_Mutation_p.E728K	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	775	PIN1-binding (By similarity).				cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GACTGTGCTTCCACAGAAACC	0.433													4	79					0	0	0	0	T	47737808	T	T	47737808	3	4	51	1	0	0	0	0	1	0	0	0	15348	864	30	2	1563	2	STIL	1	47737808	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	1001461	47737808	201512813	8	10130											
ANGPTL3	27329	broad.mit.edu	37	chr1	63063358	63063358	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcaagatttgctatgttaGacgatgtaaaaattttagcc	15	14	7	5	1	1	2	1	0	0	2	1	3	1	2	1	0	2	3	1	0	8	6			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:63063358G>A	uc001das.1	+	1	172	c.121G>A	c.(121-123)GAC>AAC	p.D41N	DOCK7_uc001dan.2_Intron|DOCK7_uc001dao.2_Intron|DOCK7_uc001dap.2_Intron|DOCK7_uc001daq.2_Intron|DOCK7_uc009wah.1_Intron	NM_014495	NP_055310	Q9Y5C1	ANGL3_HUMAN	angiopoietin-like 3 precursor	41					acylglycerol homeostasis|artery morphogenesis|cell-matrix adhesion|cholesterol homeostasis|cholesterol metabolic process|fatty acid metabolic process|glycerol metabolic process|integrin-mediated signaling pathway|lipid storage|negative regulation of lipoprotein lipase activity|negative regulation of phospholipase activity|phospholipid catabolic process|phospholipid homeostasis|positive regulation of angiogenesis|positive regulation of cell migration|positive regulation of lipid catabolic process|triglyceride homeostasis	extracellular space	cell surface binding|growth factor activity|integrin binding|phospholipase inhibitor activity				0						TGCTATGTTAGACGATGTAAA	0.348													16	95					0	0	0	0	A	63063358	A	A	63063358	3	1	51	1	0	0	0	0	1	0	0	0	615	942	33	2	123	2	ANGPTL3	1	63063358	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	15325550	63063358	186187263	9	10131											
PDE4B	5142	broad.mit.edu	37	chr1	66827468	66827468	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acactgaaaatgaagatcacCtggccaaggtgtgtataagc	15	8	10	8	0	1	3	1	2	0	1	1	3	1	3	2	2	1	1	2	2	6	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:66827468C>A	uc001dcn.2	+	10	1203	c.1012C>A	c.(1012-1014)CTG>ATG	p.L338M	PDE4B_uc009war.2_Missense_Mutation_p.L246M|PDE4B_uc001dco.2_Missense_Mutation_p.L338M|PDE4B_uc001dcp.2_Missense_Mutation_p.L323M|PDE4B_uc001dcq.2_Missense_Mutation_p.L166M|PDE4B_uc009was.2_Missense_Mutation_p.L105M	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	338					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	TGAAGATCACCTGGCCAAGGT	0.408													4	72					0.00909568	0.00944054	1	0	A	66827468	A	A	66827468	3	1	51	1	0	0	0	0	1	0	0	0	11694	680	24	4	1404	4	PDE4B	1	66827468	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	3764110	66827468	182423153	10	10132											
LRRC7	57554	broad.mit.edu	37	chr1	70504158	70504158	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caatccttggcagaattggaCcagaacccctagtccgtttg	10	10	9	12	1	0	2	0	0	0	2	2	3	2	3	5	2	1	2	5	2	4	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:70504158C>T	uc001dep.2	+	19	2567	c.2537C>T	c.(2536-2538)ACC>ATC	p.T846I	LRRC7_uc009wbg.2_Missense_Mutation_p.T130I|LRRC7_uc001deq.2_Missense_Mutation_p.T87I	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	846						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CAGAATTGGACCAGAACCCCT	0.488													13	150					0	0	0	0	T	70504158	T	T	70504158	3	4	51	1	0	0	0	0	1	0	0	0	9070	507	18	4	2611	4	LRRC7	1	70504158	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	3676690	70504158	178746463	11	10133											
EXTL2	2135	broad.mit.edu	37	chr1	101339860	101339860	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaatgaggctccaatcagcaCcatagagtactggtcaccat	13	8	9	11	0	2	2	2	1	0	1	3	3	3	2	3	2	2	3	3	2	4	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:101339860C>A	uc001dtk.1	-	5	968	c.631G>T	c.(631-633)GTG>TTG	p.V211L	EXTL2_uc001dtl.1_Missense_Mutation_p.V211L|EXTL2_uc010ouk.1_Missense_Mutation_p.V198L|EXTL2_uc001dtm.1_Missense_Mutation_p.V210L	NM_001439	NP_001430	Q9UBQ6	EXTL2_HUMAN	exostoses-like 2	211	Lumenal (Potential).				N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		CCAATCAGCACCATAGAGTAC	0.413													10	94					2.17888e-05	2.33909e-05	1	0	A	101339860	A	A	101339860	3	1	51	1	0	0	0	0	1	0	0	0	5351	507	18	4	365	4	EXTL2	1	101339860	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	30835702	101339860	147910761	12	10134											
DENND2D	79961	broad.mit.edu	37	chr1	111738609	111738609	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcagggaaggctgcctctcGgaggccctgcatgaacgggt	8	6	16	11	2	1	1	0	1	1	0	2	3	1	3	2	5	4	3	2	5	2	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:111738609G>A	uc001eak.1	-	6	774	c.574C>T	c.(574-576)CGA>TGA	p.R192*	DENND2D_uc001eal.1_Nonsense_Mutation_p.R189*	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	192	DENN.									ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		GCTGCCTCTCGGAGGCCCTGC	0.567													11	113					0	0	0	0	A	111738609	A	A	111738609	4	1	51	1	0	0	0	0	0	1	0	0	4453	1124	39	1	869	1	DENND2D	1	111738609	Nonsense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	10398749	111738609	137512012	13	10135											
UBAP2L	9898	broad.mit.edu	37	chr1	154227358	154227358	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagttacagaccacacaatCtgttgaaggtgagtgttctt	11	12	10	8	0	2	3	0	2	2	1	2	3	2	3	1	1	1	4	1	1	3	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:154227358C>T	uc001fep.3	+	16	2068	c.1901C>T	c.(1900-1902)TCT>TTT	p.S634F	UBAP2L_uc009wot.2_Missense_Mutation_p.S634F|UBAP2L_uc010pek.1_Missense_Mutation_p.S626F|UBAP2L_uc010pel.1_Missense_Mutation_p.S644F|UBAP2L_uc010pen.1_Missense_Mutation_p.S548F|UBAP2L_uc001feq.2_5'Flank|UBAP2L_uc001fer.2_5'Flank	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	634					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACCACACAATCTGTTGAAGGT	0.398													11	96					0	0	0	0	T	154227358	T	T	154227358	3	4	51	1	0	0	0	0	1	0	0	0	16906	913	32	2	1959	2	UBAP2L	1	154227358	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	42488749	154227358	95023263	14	10136											
MRPL24	79590	broad.mit.edu	37	chr1	156708205	156708205	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccactttgccctgcttcccgGcatccttgccttctaggatc	4	13	7	17	1	1	0	0	0	1	0	4	1	3	1	5	2	3	2	5	2	1	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:156708205G>A	uc001fpw.1	-	3	348	c.209C>T	c.(208-210)GCC>GTC	p.A70V	MRPL24_uc001fpx.1_Missense_Mutation_p.A70V	NM_024540	NP_078816	Q96A35	RM24_HUMAN	mitochondrial ribosomal protein L24 precursor	70	KOW.				translation	mitochondrion|ribosome	structural constituent of ribosome				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGCTTCCCGGCATCCTTGCC	0.567													7	460					0	0	0	0	A	156708205	A	A	156708205	3	1	51	1	0	0	0	0	1	0	0	0	9843	1203	42	4	457	4	MRPL24	1	156708205	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	2480847	156708205	92542416	15	10137											
CEP350	9857	broad.mit.edu	37	chr1	180064865	180064865	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaacctaaaagagtaaccCaacaaccatgtgaaacatta	20	6	5	10	0	0	3	0	1	0	2	0	3	0	3	3	0	5	1	3	0	8	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:180064865C>G	uc001gnt.2	+	35	9102	c.8719C>G	c.(8719-8721)CAA>GAA	p.Q2907E	CEP350_uc009wxl.2_Missense_Mutation_p.Q2906E|CEP350_uc001gnv.2_Missense_Mutation_p.Q1042E|CEP350_uc001gnw.1_Missense_Mutation_p.Q664E|CEP350_uc001gnx.1_Missense_Mutation_p.Q664E	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2907						centrosome|nucleus|spindle				ovary(4)	4						AAGAGTAACCCAACAACCATG	0.383													8	89					0	0	0	0	G	180064865	G	G	180064865	3	3	51	1	0	0	0	0	1	0	0	0	3269	595	21	4	8853	4	CEP350	1	180064865	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	23356660	180064865	69185756	16	10138											
KIAA1614	57710	broad.mit.edu	37	chr1	180885439	180885439	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aacatccagcctgatggcccCccagcctcccagggtatggg	8	6	11	16	0	0	1	0	1	0	0	2	1	2	1	7	3	3	1	7	3	2	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:180885439C>A	uc001gok.2	+	2	267	c.200C>A	c.(199-201)CCC>CAC	p.P67H		NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	67										ovary(3)|skin(1)	4						CTGATGGCCCCCCAGCCTCCC	0.602													8	68					0.000157383	0.000166507	1	0	A	180885439	A	A	180885439	3	1	51	1	0	0	0	0	1	0	0	0	8287	623	22	4	206	4	KIAA1614	1	180885439	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	820574	180885439	68365182	17	10139											
NCF2	4688	broad.mit.edu	37	chr1	183532571	183532571	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctgcatggagctcacctCagcttagtgtgttccagccg	6	11	11	13	1	2	0	2	0	0	0	3	1	3	1	4	1	5	4	4	1	1	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:183532571C>T	uc001gqj.3	-	12	1451	c.1176G>A	c.(1174-1176)CTG>CTA	p.L392L	NCF2_uc010pod.1_Silent_p.L347L|NCF2_uc010poe.1_Silent_p.L311L|NCF2_uc001gqk.3_Silent_p.L392L	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	392	OPR.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						GAGCTCACCTCAGCTTAGTGT	0.557													20	339					0	0	0	0	T	183532571	T	T	183532571	2	4	51	1	0	0	0	0	0	0	0	1	10271	813	29	2		2	NCF2	1	183532571	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	2647132	183532571	65718050	18	10140											
ADORA1	134	broad.mit.edu	37	chr1	203134708	203134708	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgtcggcctcctccggcGacccgcagaagtactatggg	7	7	14	13	4	0	1	0	0	0	1	3	2	2	1	4	4	1	2	4	4	3	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:203134708G>T	uc001gze.1	+	4	1094	c.661G>T	c.(661-663)GAC>TAC	p.D221Y	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Missense_Mutation_p.D221Y|ADORA1_uc010pqg.1_Missense_Mutation_p.D153Y|ADORA1_uc009xak.1_Missense_Mutation_p.R146L|ADORA1_uc010pqh.1_Missense_Mutation_p.D254Y	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	221	Cytoplasmic (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	CTCCTCCGGCGACCCGCAGAA	0.582													17	157					2.37509e-13	2.69505e-13	1	0	T	203134708	T	T	203134708	3	4	51	1	0	0	0	0	1	0	0	0	326	1058	37	3	667	3	ADORA1	1	203134708	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	19602137	203134708	46115913	19	10141											
FMOD	2331	broad.mit.edu	37	chr1	203311480	203311480	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccagggctgctcagatctcGatgaggctggcaaggcgcag	8	6	16	11	2	2	2	1	1	1	1	3	3	2	2	1	4	1	5	1	4	1	0	rs141336017	byFrequency	TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:203311480G>A	uc001gzr.2	-	3	1258	c.1122C>T	c.(1120-1122)ATC>ATT	p.I374I	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	374					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			CTCAGATCTCGATGAGGCTGG	0.637											OREG0014119	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	83					0	0	0	0	A	203311480	A	A	203311480	2	1	51	1	0	0	0	0	0	0	0	1	5991	1048	37	1		1	FMOD	1	203311480	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	176772	203311480	45939141	20	10142											
HHIPL2	79802	broad.mit.edu	37	chr1	222717278	222717278	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccaccatgcccaggtggCggttgagatagtcgttcctc	6	9	14	12	2	0	1	0	1	0	1	3	2	1	1	4	4	1	2	4	4	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:222717278C>T	uc001hnh.1	-	2	633	c.575G>A	c.(574-576)CGC>CAC	p.R192H		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	192					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GCCCAGGTGGCGGTTGAGATA	0.602													10	117					0	0	0	0	T	222717278	T	T	222717278	3	4	51	1	0	0	0	0	1	0	0	0	7133	768	27	1	1631	1	HHIPL2	1	222717278	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	19405798	222717278	26533343	21	10143											
RBM34	23029	broad.mit.edu	37	chr1	235324586	235324586	+	5'Flank	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagctgcgcgccagctcgcActtccgggttccgggcactt	4	8	13	16	5	0	0	0	0	0	0	3	0	2	0	3	2	3	6	3	2	0	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr1:235324586A>G	uc001hwn.2	-						RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_5'Flank	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1							nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			GCCAGCTCGCACTTCCGGGTT	0.667													9	70					0	0	0	0	G	235324586	G	G	235324586	1	3	51	0	1	0	0	0	0	0	0	0	13196	174	6	5		5	RBM34	1	235324586	5'Flank	SNP	A	TCGA-CN-4740-01A-01D-1434-08	12607308	235324586	13926035	22	10144											
AGBL5	60509	broad.mit.edu	37	chr2	27279594	27279594	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgtatgcccgagaccgtaGagatggccagtctaaagagg	12	8	13	8	2	1	3	0	0	1	3	1	5	1	3	3	2	1	2	3	2	5	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:27279594G>C	uc002rie.2	+	8	1686	c.1469G>C	c.(1468-1470)AGA>ACA	p.R490T	AGBL5_uc002rid.2_Missense_Mutation_p.R490T|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	490					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGAGACCGTAGAGATGGCCAG	0.463													28	229					0	0	0	0	C	27279594	C	C	27279594	3	2	51	1	0	0	0	0	1	0	0	0	378	942	33	2	1495	2	AGBL5	2	27279594	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08		27279594	215919779	23	10145											
CCDC88A	55704	broad.mit.edu	37	chr2	55589533	55589533	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgtcctcctgcgacatatCagtcacttccatccattgca	9	13	5	14	1	2	0	2	0	0	0	6	1	6	0	4	0	2	1	4	0	2	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:55589533C>G	uc002ryv.2	-	7	1380	c.538G>C	c.(538-540)GAT>CAT	p.D180H	CCDC88A_uc010yoz.1_Missense_Mutation_p.D180H|CCDC88A_uc010ypa.1_Missense_Mutation_p.D180H|CCDC88A_uc010ypb.1_Missense_Mutation_p.D82H	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	180					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TGCGACATATCAGTCACTTCC	0.348													5	54					0	0	0	0	G	55589533	G	G	55589533	3	3	51	1	0	0	0	0	1	0	0	0	2876	826	29	2	5181	2	CCDC88A	2	55589533	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	28309939	55589533	187609840	24	10146											
EFEMP1	2202	broad.mit.edu	37	chr2	56144916	56144916	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccggatgacaaagttatttCggccagtctgcatttcaggg	9	11	12	9	2	2	1	1	1	1	0	3	2	2	2	2	3	1	2	2	3	2	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:56144916C>T	uc002rzh.2	-	4	731	c.401G>A	c.(400-402)CGA>CAA	p.R134Q	EFEMP1_uc002rzi.2_Missense_Mutation_p.R134Q|EFEMP1_uc002rzj.2_Missense_Mutation_p.R134Q|EFEMP1_uc010ypc.1_Missense_Mutation_p.R76Q	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	134					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AAAGTTATTTCGGCCAGTCTG	0.587													17	109					0	0	0	0	T	56144916	T	T	56144916	3	4	51	1	0	0	0	0	1	0	0	0	4963	884	31	1	1112	1	EFEMP1	2	56144916	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	555383	56144916	187054457	25	10147											
MFSD9	84804	broad.mit.edu	37	chr2	103353179	103353179	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggagtcggcagcctccgcctCggttcctgtcttctgctcct	2	12	11	16	3	2	0	0	0	2	0	7	1	5	1	5	3	2	3	5	3	0	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:103353179C>G	uc002tcb.2	-	1	159	c.91G>C	c.(91-93)GAG>CAG	p.E31Q	TMEM182_uc002tcc.3_5'Flank|TMEM182_uc002tcd.3_5'Flank|MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	31					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						GCCTCCGCCTCGGTTCCTGTC	0.672													6	58					0	0	0	0	G	103353179	G	G	103353179	3	3	51	1	0	0	0	0	1	0	0	0	9592	893	31	3	1357	3	MFSD9	2	103353179	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	47208263	103353179	139846194	26	10148											
UGGT1	56886	broad.mit.edu	37	chr2	128865573	128865573	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttcagtttctgtcacccctCcagcagaatttgtttaaatt	9	17	5	10	0	3	1	2	0	1	1	4	1	4	1	3	0	1	3	3	0	3	6			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:128865573C>G	uc002tps.2	+	4	517	c.339C>G	c.(337-339)CTC>CTG	p.L113L	UGGT1_uc010fme.1_Intron|UGGT1_uc002tpr.2_Silent_p.L89L	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	113					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						TGTCACCCCTCCAGCAGAATT	0.418													26	192					0	0	0	0	G	128865573	G	G	128865573	2	3	51	1	0	0	0	0	0	0	0	1	17009	842	30	2		2	UGGT1	2	128865573	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	25512394	128865573	114333800	27	10149											
SCN1A	6323	broad.mit.edu	37	chr2	166868758	166868758	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attccaacatcgtcttaatcGtctttcgctgatcaatatat	11	16	4	10	3	3	1	1	1	2	0	7	1	4	1	1	0	1	1	1	0	5	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:166868758G>A	uc010zcz.1	-	19	3725	c.3707C>T	c.(3706-3708)ACG>ATG	p.T1236M	SCN1A_uc002udo.3_Missense_Mutation_p.T1116M|SCN1A_uc010fpk.2_Missense_Mutation_p.T1088M	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1247	III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CGTCTTAATCGTCTTTCGCTG	0.294													12	42					0	0	0	0	A	166868758	A	A	166868758	3	1	51	1	0	0	0	0	1	0	0	0	13979	1145	40	1	2321	1	SCN1A	2	166868758	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	38003185	166868758	76330615	28	10150											
TTN	7273	broad.mit.edu	37	chr2	179497064	179497064	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggatgttatcatgagataaCtccacagtaaatacagcact	15	10	7	9	1	1	1	1	1	0	1	2	3	2	2	1	1	3	3	1	1	5	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:179497064C>T	uc010zfg.1	-	185	36077	c.35853G>A	c.(35851-35853)GAG>GAA	p.E11951E	TTN_uc010zfh.1_Silent_p.E5646E|TTN_uc010zfi.1_Silent_p.E5579E|TTN_uc010zfj.1_Silent_p.E5454E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12878							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATGAGATAACTCCACAGTAA	0.428													3	16					0	0	0	0	T	179497064	T	T	179497064	2	4	51	1	0	0	0	0	0	0	0	1	16803	564	20	4		4	TTN	2	179497064	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	12628306	179497064	63702309	29	10151											
TTN	7273	broad.mit.edu	37	chr2	179500746	179500746	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcgttttccacagtaactGtgtatgttccagcatctgtg	7	15	10	9	1	1	0	0	0	1	0	3	0	3	0	2	1	2	5	2	1	2	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:179500746G>A	uc010zfg.1	-	175	34072	c.33848C>T	c.(33847-33849)ACA>ATA	p.T11283I	TTN_uc010zfh.1_Missense_Mutation_p.T4978I|TTN_uc010zfi.1_Missense_Mutation_p.T4911I|TTN_uc010zfj.1_Missense_Mutation_p.T4786I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12210							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACAGTAACTGTGTATGTTCC	0.468													16	163					0	0	0	0	A	179500746	A	A	179500746	3	1	51	1	0	0	0	0	1	0	0	0	16803	1377	48	4	66689	4	TTN	2	179500746	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	3682	179500746	63698627	30	10152											
NEUROD1	4760	broad.mit.edu	37	chr2	182543116	182543116	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtctgggcttttgcctgagcGcaggatctccgacagagccc	6	9	13	13	2	2	2	0	1	2	1	3	4	2	3	3	2	3	2	3	2	0	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:182543116G>A	uc002uof.2	-	2	708	c.472C>T	c.(472-474)CGC>TGC	p.R158C	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	158					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TTGCCTGAGCGCAGGATCTCC	0.562													8	130					0	0	0	0	A	182543116	A	A	182543116	3	1	51	1	0	0	0	0	1	0	0	0	10402	1087	38	1	602	1	NEUROD1	2	182543116	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	3042370	182543116	60656257	31	10153											
WNT6	7475	broad.mit.edu	37	chr2	219736445	219736445	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgacgtggacttcggggaCgagaagtcgaggctctttat	9	9	15	8	5	1	1	0	0	1	1	3	7	1	3	0	4	0	1	0	4	2	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:219736445C>T	uc002vjc.1	+	3	755	c.540C>T	c.(538-540)GAC>GAT	p.D180D		NM_006522	NP_006513	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family,	180					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(2)|skin(1)	3		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACTTCGGGGACGAGAAGTCGA	0.557													3	23					0	0	0	0	T	219736445	T	T	219736445	2	4	51	1	0	0	0	0	0	0	0	1	17461	535	19	1		1	WNT6	2	219736445	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	37193329	219736445	23462928	32	10154											
PTPRN	5798	broad.mit.edu	37	chr2	220161532	220161532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctccaccttcagttttatgCgggcatggtcatctgcacag	7	13	9	12	1	4	0	2	0	2	0	5	0	4	0	2	2	2	3	2	2	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr2:220161532C>T	uc002vkz.2	-	16	2338	c.2249G>A	c.(2248-2250)CGC>CAC	p.R750H	PTPRN_uc010zlc.1_Missense_Mutation_p.R660H|PTPRN_uc002vla.2_Missense_Mutation_p.R721H|uc010zld.1_5'Flank|MIR153-1_hsa-mir-153-1|MI0000463_5'Flank	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	750	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CAGTTTTATGCGGGCATGGTC	0.617													3	46					0	0	0	0	T	220161532	T	T	220161532	3	4	51	1	0	0	0	0	1	0	0	0	12872	768	27	1	722	1	PTPRN	2	220161532	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	425087	220161532	23037841	33	10155											
CSPG5	10675	broad.mit.edu	37	chr3	47619197	47619197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcggtcactcctcccaggcCtgggctgtcagcttccagcc	4	9	11	17	1	2	0	2	0	0	0	5	0	5	0	5	3	3	2	5	3	0	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr3:47619197C>T	uc003crp.3	-	2	495	c.319G>A	c.(319-321)GGC>AGC	p.G107S	CSPG5_uc003crn.2_5'UTR|CSPG5_uc003cro.3_Missense_Mutation_p.G107S|CSPG5_uc011bbb.1_5'UTR	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	107	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CCTCCCAGGCCTGGGCTGTCA	0.716													10	76					0	0	0	0	T	47619197	T	T	47619197	3	4	51	1	0	0	0	0	1	0	0	0	3978	681	24	4	1316	4	CSPG5	3	47619197	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08		47619197	150403233	34	10156											
CRYBG3	131544	broad.mit.edu	37	chr3	97596124	97596124	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctgtcttgtttcatgataCgtccgctgacagcatgcctg	6	14	10	11	2	3	2	1	2	2	0	4	2	4	2	2	0	3	3	2	0	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr3:97596124C>T	uc003drx.2	+	1	306	c.242C>T	c.(241-243)ACG>ATG	p.T81M		NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						TTTCATGATACGTCCGCTGAC	0.423													12	100					0	0	0	0	T	97596124	T	T	97596124	3	4	51	1	0	0	0	0	1	0	0	0	3928	536	19	1	244	1	CRYBG3	3	97596124	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	49976927	97596124	100426306	35	10157											
ESYT3	83850	broad.mit.edu	37	chr3	138178826	138178826	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcctggagcccctcctaGtggacaagccctttgtggga	7	10	11	13	0	1	0	1	0	0	0	3	3	3	3	5	3	2	0	5	3	2	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr3:138178826G>A	uc003esk.2	+	6	914	c.688G>A	c.(688-690)GTG>ATG	p.V230M	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	230						integral to membrane|plasma membrane					0						GCCCCTCCTAGTGGACAAGCC	0.632													24	122					0	0	0	0	A	138178826	A	A	138178826	3	1	51	1	0	0	0	0	1	0	0	0	5290	1029	36	4	710	4	ESYT3	3	138178826	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	40582702	138178826	59843604	36	10158											
VEPH1	79674	broad.mit.edu	37	chr3	157004456	157004456	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagatggagctgtacctggTccagatcctgtgtcaggaac	9	9	12	11	0	1	2	1	0	0	2	3	4	3	4	4	3	3	2	4	3	2	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr3:157004456T>A	uc003fbj.1	-	12	2335	c.2018A>T	c.(2017-2019)GAC>GTC	p.D673V	VEPH1_uc003fbk.1_Missense_Mutation_p.D673V|VEPH1_uc010hvu.1_Missense_Mutation_p.D628V	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	673						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CTGTACCTGGTCCAGATCCTG	0.493													10	125					0	0	0	0	A	157004456	A	A	157004456	3	1	51	1	0	0	0	0	1	0	0	0	17222	1667	58	5	495	5	VEPH1	3	157004456	Missense_Mutation	SNP	T	TCGA-CN-4740-01A-01D-1434-08	18825630	157004456	41017974	37	10159											
MCF2L2	23101	broad.mit.edu	37	chr3	182925545	182925545	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atccttcattttataacgatCcttgtgaattgtccagacgc	10	15	6	10	2	1	2	1	1	0	1	4	3	4	2	3	0	1	0	3	0	3	6			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr3:182925545C>T	uc003fli.1	-	23	2653	c.2563G>A	c.(2563-2565)GAT>AAT	p.D855N		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	855	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TTATAACGATCCTTGTGAATT	0.423													20	84					0	0	0	0	T	182925545	T	T	182925545	3	4	51	1	0	0	0	0	1	0	0	0	9433	855	30	2	813	2	MCF2L2	3	182925545	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	25921089	182925545	15096885	38	10160											
CRMP1	1400	broad.mit.edu	37	chr4	5862865	5862865	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgttgacatcaatacctccGggaataaccatccgcccgtt	10	10	8	13	3	1	1	1	1	0	0	3	2	3	2	5	1	2	2	5	1	4	4	rs145307270		TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:5862865G>A	uc003gip.2	-	4	302	c.201C>T	c.(199-201)CCC>CCT	p.P67P	CRMP1_uc003gin.1_Intron|CRMP1_uc003giq.2_Silent_p.P67P|CRMP1_uc003gir.2_Silent_p.P62P|CRMP1_uc003gis.2_Silent_p.P181P	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	67					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		CAATACCTCCGGGAATAACCA	0.552													5	219					0	0	0	0	A	5862865	A	A	5862865	2	1	51	1	0	0	0	0	0	0	0	1	3905	1103	39	1		1	CRMP1	4	5862865	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08		5862865	185291411	39	10161											
PCDH7	5099	broad.mit.edu	37	chr4	30724332	30724332	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccccctcaaggacggggtgGccaacgtggccgaggacgtt	7	6	15	13	4	1	0	1	0	0	0	2	3	2	2	4	6	1	1	4	6	2	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:30724332G>A	uc003gsk.1	+	1	2296	c.1288G>A	c.(1288-1290)GCC>ACC	p.A430T	PCDH7_uc011bxw.1_Missense_Mutation_p.A383T|PCDH7_uc011bxx.1_Missense_Mutation_p.A430T	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	430	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GGACGGGGTGGCCAACGTGGC	0.617													3	58					0	0	0	0	A	30724332	A	A	30724332	3	1	51	1	0	0	0	0	1	0	0	0	11570	1203	42	4	1290	4	PCDH7	4	30724332	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	24861467	30724332	160429944	40	10162											
PHOX2B	8929	broad.mit.edu	37	chr4	41748274	41748274	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggagccgttcttggccgcGgccgctgcggctgccgctgc	2	7	17	15	6	1	0	0	0	1	0	1	2	1	1	4	4	4	4	4	4	0	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:41748274G>A	uc003gwf.3	-	3	855	c.495C>T	c.(493-495)GCC>GCT	p.A165A		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	165	Poly-Ala.				positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						TCTTGGCCGCGGCCGCTGCGG	0.657			Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				8	35					0	0	0	0	A	41748274	A	A	41748274	2	1	51	1	0	0	0	0	0	0	0	1	11914	1103	39	1		1	PHOX2B	4	41748274	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	11023942	41748274	149406002	41	10163											
GRXCR1	389207	broad.mit.edu	37	chr4	42895345	42895345	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagtccggtttcggatcgCgtcctctcacagtgggcgag	7	9	14	11	5	1	0	1	0	1	0	6	3	3	1	2	3	0	1	2	3	1	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:42895345C>T	uc003gwt.2	+	1	62	c.62C>T	c.(61-63)GCG>GTG	p.A21V		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	21					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						TTTCGGATCGCGTCCTCTCAC	0.507													5	181					0	0	0	0	T	42895345	T	T	42895345	3	4	51	1	0	0	0	0	1	0	0	0	6851	768	27	1	64	1	GRXCR1	4	42895345	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	1147071	42895345	148258931	42	10164											
KIAA1211	57482	broad.mit.edu	37	chr4	57190422	57190422	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggccaatactcttcctacGtctgtgacaggtagagagca	12	9	10	10	1	2	2	0	1	2	1	3	3	3	2	2	2	3	2	2	2	5	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:57190422G>A	uc003hbk.2	+	10	3922	c.3531G>A	c.(3529-3531)ACG>ACA	p.T1177T	KIAA1211_uc010iha.2_Silent_p.T1170T	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	1177										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CTCTTCCTACGTCTGTGACAG	0.488													24	63					0	0	0	0	A	57190422	A	A	57190422	2	1	51	1	0	0	0	0	0	0	0	1	8254	1132	40	1		1	KIAA1211	4	57190422	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	14295077	57190422	133963854	43	10165											
TMPRSS11D	9407	broad.mit.edu	37	chr4	68725342	68725342	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actacccctgcgacgacaatGaaacatactacatatggatt	15	9	6	11	2	0	1	0	1	0	0	0	4	0	2	2	1	5	0	2	1	6	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:68725342G>A	uc003hdq.2	-	2	128	c.63C>T	c.(61-63)TTC>TTT	p.F21F	LOC550112_uc003hdl.3_Intron|TMPRSS11D_uc011caj.1_Intron	NM_004262	NP_004253	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	21	Helical; Signal-anchor for type II membrane protein; (Potential).				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						CGACGACAATGAAACATACTA	0.383													5	97					0	0	0	0	A	68725342	A	A	68725342	2	1	51	1	0	0	0	0	0	0	0	1	16307	1281	45	2		2	TMPRSS11D	4	68725342	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	11534920	68725342	122428934	44	10166											
ENAM	10117	broad.mit.edu	37	chr4	71507743	71507743	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctacagaatccttacttTggatattttggatatcatgg	10	17	7	7	0	1	1	1	0	0	1	3	3	3	3	2	3	2	0	2	3	5	8			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:71507743T>C	uc011caw.1	+	9	881	c.600T>C	c.(598-600)TTT>TTC	p.F200F		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	200					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			ATCCTTACTTTGGATATTTTG	0.353													70	300					0	0	0	0	C	71507743	C	C	71507743	2	2	51	1	0	0	0	0	0	0	0	1	5136	1809	63	5		5	ENAM	4	71507743	Silent	SNP	T	TCGA-CN-4740-01A-01D-1434-08	2782401	71507743	119646533	45	10167											
THAP9	79725	broad.mit.edu	37	chr4	83839109	83839109	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggatttttgctcaatgctGagagcttaaaatggctctac	10	14	10	7	0	2	1	1	1	1	1	2	3	2	2	0	2	4	4	0	2	4	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:83839109G>A	uc003hnt.2	+	5	1863	c.1744G>A	c.(1744-1746)GAG>AAG	p.E582K	THAP9_uc003hns.1_Missense_Mutation_p.E438K|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_Missense_Mutation_p.E299K	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	582							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				GCTCAATGCTGAGAGCTTAAA	0.333													5	90					0	0	0	0	A	83839109	A	A	83839109	3	1	51	1	0	0	0	0	1	0	0	0	15917	1291	45	2	1762	2	THAP9	4	83839109	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	12331366	83839109	107315167	46	10168											
SCLT1	132320	broad.mit.edu	37	chr4	129864201	129864201	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcaatcttccttaaactctCagtctctttccgtaactgtt	8	16	5	12	1	3	0	1	0	3	0	7	0	5	0	2	1	2	3	2	1	4	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:129864201C>G	uc003igp.2	-	17	2088	c.1582G>C	c.(1582-1584)GAG>CAG	p.E528Q	SCLT1_uc003ign.2_Missense_Mutation_p.E192Q|SCLT1_uc003igo.2_Missense_Mutation_p.E138Q|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	528	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						CTTAAACTCTCAGTCTCTTTC	0.363													13	240					0	0	0	0	G	129864201	G	G	129864201	3	3	51	1	0	0	0	0	1	0	0	0	13971	835	29	2	504	2	SCLT1	4	129864201	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	46025092	129864201	61290075	47	10169											
PCDH18	54510	broad.mit.edu	37	chr4	138452188	138452188	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaggttgatgttaatttcaGgtttattgtcattaacatcc	10	18	8	5	0	2	2	2	2	0	0	3	2	3	2	1	2	1	3	1	2	3	7			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:138452188G>C	uc003ihe.3	-	1	1442	c.1055C>G	c.(1054-1056)CCT>CGT	p.P352R	PCDH18_uc003ihf.3_Missense_Mutation_p.P345R|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.P132R|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	352	Cadherin 3.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					GTTAATTTCAGGTTTATTGTC	0.358													19	90					0	0	0	0	C	138452188	C	C	138452188	3	2	51	1	0	0	0	0	1	0	0	0	11567	1000	35	4	2368	4	PCDH18	4	138452188	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	8587987	138452188	52702088	48	10170											
SC4MOL	6307	broad.mit.edu	37	chr4	166254491	166254491	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatatgtattcatttctacaGaattataaggctgtctgcag	12	16	7	6	0	3	1	1	0	2	1	3	1	3	1	0	1	2	3	0	1	7	8			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:166254491G>T	uc003ire.2	+	2	100	c.-30_splice	c.e2-1		SC4MOL_uc010irb.2_Splice_Site|SC4MOL_uc003irf.2_Intron	NM_006745	NP_006736	Q15800	ERG25_HUMAN	sterol-C4-methyl oxidase-like isoform 1						cholesterol biosynthetic process|fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	C-4 methylsterol oxidase activity|iron ion binding				0	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0875)	NADH(DB00157)	CATTTCTACAGAATTATAAGG	0.294													6	104					3.59834e-05	3.84408e-05	1	0	T	166254491	T	T	166254491	5	4	51	1	0	0	0	0	0	0	1	0	13930	956	33	2		2	SC4MOL	4	166254491	Splice_Site	SNP	G	TCGA-CN-4740-01A-01D-1434-08	27802303	166254491	24899785	49	10171											
SORBS2	8470	broad.mit.edu	37	chr4	186544853	186544853	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatgggcaccagggcgttaGactggcagcctcgccggccc	7	5	15	14	3	0	1	0	0	0	1	1	2	0	1	4	4	1	3	4	4	2	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:186544853G>C	uc003iyl.2	-	13	2576	c.1718C>G	c.(1717-1719)TCT>TGT	p.S573C	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.S673C|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.S477C|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.S687C|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	573						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CAGGGCGTTAGACTGGCAGCC	0.592													17	82					0	0	0	0	C	186544853	C	C	186544853	3	2	51	1	0	0	0	0	1	0	0	0	14992	942	33	2	1620	2	SORBS2	4	186544853	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	20290362	186544853	4609423	50	10172											
SORBS2	8470	broad.mit.edu	37	chr4	186545169	186545169	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttcacggagcagatcacctCggagttcatcaggtccttgc	8	10	10	13	2	4	1	4	0	0	1	6	3	5	3	2	3	2	2	2	3	0	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr4:186545169C>T	uc003iyl.2	-	13	2260	c.1402G>A	c.(1402-1404)GAG>AAG	p.E468K	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.E568K|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.E372K|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.E582K|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	468						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CAGATCACCTCGGAGTTCATC	0.587													14	201					0	0	0	0	T	186545169	T	T	186545169	3	4	51	1	0	0	0	0	1	0	0	0	14992	893	31	1	1936	1	SORBS2	4	186545169	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	316	186545169	4609107	51	10173											
ADAMTS16	170690	broad.mit.edu	37	chr5	5200364	5200364	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcaccctgcagccgccagtAtctacacaaatttctaaggt	11	10	7	13	1	3	0	1	0	2	0	3	0	3	0	3	1	3	2	3	1	4	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr5:5200364A>G	uc003jdl.2	+	9	1571	c.1433A>G	c.(1432-1434)TAT>TGT	p.Y478C	ADAMTS16_uc003jdk.1_Missense_Mutation_p.Y478C|ADAMTS16_uc003jdj.1_Missense_Mutation_p.Y478C	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	478	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						AGCCGCCAGTATCTACACAAA	0.517													12	111					0	0	0	0	G	5200364	G	G	5200364	3	3	51	1	0	0	0	0	1	0	0	0	261	449	16	5	1467	5	ADAMTS16	5	5200364	Missense_Mutation	SNP	A	TCGA-CN-4740-01A-01D-1434-08		5200364	175714896	52	10174											
C7	730	broad.mit.edu	37	chr5	40972634	40972634	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttagaaggtccttcagcatTtctctgtggctccagcctta	7	14	8	12	0	2	1	1	0	1	1	5	1	4	1	3	2	2	2	3	2	3	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr5:40972634T>G	uc003jmh.2	+	15	2126	c.2012T>G	c.(2011-2013)TTT>TGT	p.F671C	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	671	Sushi 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				CCTTCAGCATTTCTCTGTGGC	0.488													21	205					0	0	0	0	G	40972634	G	G	40972634	3	3	51	1	0	0	0	0	1	0	0	0	2386	1841	64	5	2070	5	C7	5	40972634	Missense_Mutation	SNP	T	TCGA-CN-4740-01A-01D-1434-08	35772270	40972634	139942626	53	10175											
NRG2	9542	broad.mit.edu	37	chr5	139422017	139422017	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttttgccgttggtatcgaggGgggcaaaggccgtcttaaag	8	11	15	7	3	1	0	0	0	1	0	2	1	1	0	2	5	1	3	2	5	4	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr5:139422017G>A	uc003lex.1	-	1	863	c.638C>T	c.(637-639)CCC>CTC	p.P213L	NRG2_uc003lev.1_Missense_Mutation_p.P213L|NRG2_uc003lew.1_Missense_Mutation_p.P213L|NRG2_uc003ley.1_Missense_Mutation_p.P213L	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	213	Extracellular (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTATCGAGGGGGGCAAAGGC	0.572													3	8					0	0	0	0	A	139422017	A	A	139422017	3	1	51	1	0	0	0	0	1	0	0	0	10702	1232	43	4	2045	4	NRG2	5	139422017	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	98449383	139422017	41493243	54	10176											
PCDHB6	56130	broad.mit.edu	37	chr5	140530097	140530097	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatgatttactgctaaatGaaaaactggaccgggaggag	14	8	11	8	1	0	2	0	2	0	0	0	5	0	5	2	3	3	1	2	3	5	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr5:140530097G>T	uc003lir.2	+	1	259	c.259G>T	c.(259-261)GAA>TAA	p.E87*	PCDHB6_uc011dah.1_5'UTR	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	87	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTGCTAAATGAAAAACTGGA	0.517													22	170					2.39556e-15	2.73244e-15	1	0	T	140530097	T	T	140530097	4	4	51	1	0	0	0	0	0	1	0	0	11600	1291	45	2	261	2	PCDHB6	5	140530097	Nonsense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	1108080	140530097	40385163	55	10177											
PCDHB6	56130	broad.mit.edu	37	chr5	140530481	140530481	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggctaacgctgatcgcgctgGatggcgggtctccgccccgg	4	7	16	14	6	1	1	0	1	1	0	3	2	1	2	3	5	1	3	3	5	1	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr5:140530481G>C	uc003lir.2	+	1	643	c.643G>C	c.(643-645)GAT>CAT	p.D215H	PCDHB6_uc011dah.1_Missense_Mutation_p.D79H	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	215	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GATCGCGCTGGATGGCGGGTC	0.602													6	92					0	0	0	0	C	140530481	C	C	140530481	3	2	51	1	0	0	0	0	1	0	0	0	11600	1174	41	2	645	2	PCDHB6	5	140530481	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	384	140530481	40384779	56	10178											
PCDHGA12	26025	broad.mit.edu	37	chr5	140810927	140810927	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggtgctgaaacgcgccctgGaccgcgaagaaaaggctgct	10	6	14	11	4	0	2	0	1	0	1	0	4	0	3	2	3	3	3	2	3	4	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr5:140810927G>A	uc003lkt.1	+	1	770	c.601G>A	c.(601-603)GAC>AAC	p.D201N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.D201N	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	201	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCGCCCTGGACCGCGAAGA	0.627													46	179					0	0	0	0	A	140810927	A	A	140810927	3	1	51	1	0	0	0	0	1	0	0	0	11607	1174	41	2	603	2	PCDHGA12	5	140810927	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	280446	140810927	40104333	57	10179											
PCDHGA12	26025	broad.mit.edu	37	chr5	140812206	140812206	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgcacacgggcgaggtgcGcacggcgcgagccctgctgg	5	5	17	14	6	1	0	0	0	1	0	1	2	1	0	1	4	4	3	1	4	0	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr5:140812206G>A	uc003lkt.1	+	1	2049	c.1880G>A	c.(1879-1881)CGC>CAC	p.R627H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.R627H	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	627	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGGTGCGCACGGCGCGA	0.687													10	112					0	0	0	0	A	140812206	A	A	140812206	3	1	51	1	0	0	0	0	1	0	0	0	11607	1087	38	1	1882	1	PCDHGA12	5	140812206	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	1279	140812206	40103054	58	10180											
ATP10B	23120	broad.mit.edu	37	chr5	160097667	160097667	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcacttctgcacataggtctGctcttttcttgggtgagaga	7	14	11	9	0	4	2	0	1	4	1	4	3	4	2	0	2	2	3	0	2	1	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr5:160097667G>T	uc003lym.1	-	7	1325	c.478C>A	c.(478-480)CAG>AAG	p.Q160K	ATP10B_uc003lyp.2_Missense_Mutation_p.Q160K|ATP10B_uc011deg.1_Missense_Mutation_p.Q204K|ATP10B_uc003lyo.2_Missense_Mutation_p.Q132K	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	160	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACATAGGTCTGCTCTTTTCTT	0.458													24	164					9.80776e-20	1.13047e-19	1	0	T	160097667	T	T	160097667	3	4	51	1	0	0	0	0	1	0	0	0	1119	1328	46	4	3987	4	ATP10B	5	160097667	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	19285461	160097667	20817593	59	10181											
ODZ2	57451	broad.mit.edu	37	chr5	167674088	167674088	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgacgagaccactggtgtCttgaagatggtcaacctcca	11	10	10	10	1	2	4	1	2	1	2	3	5	3	4	3	2	1	0	3	2	3	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr5:167674088C>T	uc010jjd.2	+	27	6117	c.6117C>T	c.(6115-6117)GTC>GTT	p.V2039V	ODZ2_uc003lzr.3_Silent_p.V1809V|ODZ2_uc003lzt.3_Silent_p.V1412V|ODZ2_uc010jje.2_Silent_p.V1303V	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CCACTGGTGTCTTGAAGATGG	0.537													17	152					0	0	0	0	T	167674088	T	T	167674088	2	4	51	1	0	0	0	0	0	0	0	1	10889	900	32	2		2	ODZ2	5	167674088	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	7576421	167674088	13241172	60	10182											
COL23A1	91522	broad.mit.edu	37	chr5	177697340	177697340	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgccctgtcatcacttacggGcttgccatccaaacccaggg	8	9	9	15	1	2	0	2	0	0	0	3	0	3	0	4	2	4	1	4	2	2	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr5:177697340G>A	uc003mje.2	-	6	824	c.466C>T	c.(466-468)CCC>TCC	p.P156S	COL23A1_uc010jkt.2_Silent_p.S3S	NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	156	Extracellular (Potential).|Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		TCACTTACGGGCTTGCCATCC	0.597													6	39					0	0	0	0	A	177697340	A	A	177697340	3	1	51	1	0	0	0	0	1	0	0	0	3697	1203	42	4	1252	4	COL23A1	5	177697340	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	10023252	177697340	3217920	61	10183											
HIST1H3C	8352	broad.mit.edu	37	chr6	26045748	26045748	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccggccaccggtggcgtgaAgaaacctcatcgctaccgcc	8	6	11	16	5	1	2	1	1	0	1	3	2	2	2	6	3	2	1	6	3	3	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr6:26045748A>T	uc003nfv.2	+	1	110	c.110A>T	c.(109-111)AAG>ATG	p.K37M	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	37					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GGTGGCGTGAAGAAACCTCAT	0.632													16	80					0	0	0	0	T	26045748	T	T	26045748	3	4	51	1	0	0	0	0	1	0	0	0	7196	72	3	5	112	5	HIST1H3C	6	26045748	Missense_Mutation	SNP	A	TCGA-CN-4740-01A-01D-1434-08		26045748	145069319	62	10184											
HIST1H2AC	8334	broad.mit.edu	37	chr6	26124629	26124629	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtacctggcggcggtgttaGagtacctgaccgccgagatc	7	9	14	11	4	0	3	0	1	0	2	1	4	0	3	4	3	2	3	4	3	3	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr6:26124629G>C	uc003ngm.2	+	1	257	c.169G>C	c.(169-171)GAG>CAG	p.E57Q	HIST1H2BC_uc003ngk.3_5'Flank|HIST1H2BC_uc003ngl.2_5'Flank|HIST1H2AC_uc003ngn.2_RNA|HIST1H2AC_uc003ngo.2_RNA|HIST1H2AC_uc003ngp.2_Missense_Mutation_p.E57Q	NM_003512	NP_003503	Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	57					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GGCGGTGTTAGAGTACCTGAC	0.662													10	46					0	0	0	0	C	26124629	C	C	26124629	3	2	51	1	0	0	0	0	1	0	0	0	7169	943	33	2	171	2	HIST1H2AC	6	26124629	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	78881	26124629	144990438	63	10185											
ZKSCAN3	80317	broad.mit.edu	37	chr6	28333970	28333970	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acactggtgagaaaccctatCagtgtaatgcgtgtggaaaa	14	9	11	7	1	1	1	1	1	0	1	1	3	1	2	1	2	2	1	1	2	5	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr6:28333970C>T	uc003nle.3	+	6	1741	c.1525C>T	c.(1525-1527)CAG>TAG	p.Q509*	ZKSCAN3_uc010jrc.2_Nonsense_Mutation_p.Q509*|ZKSCAN3_uc003nlf.3_Nonsense_Mutation_p.Q361*|uc010jrd.2_5'Flank	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	509	C2H2-type 7.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GAAACCCTATCAGTGTAATGC	0.413													7	78					0	0	0	0	T	28333970	T	T	28333970	4	4	51	1	0	0	0	0	0	1	0	0	17755	827	29	2	1543	2	ZKSCAN3	6	28333970	Nonsense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	2209341	28333970	142781097	64	10186											
CFB	629	broad.mit.edu	37	chr6	31918538	31918538	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aagaataagctgaaatatggCcagactatcaggtgagagcg	16	7	12	6	1	1	4	1	2	0	3	1	5	1	4	1	2	2	1	1	2	6	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr6:31918538C>T	uc003nyj.3	+	13	2045	c.1767C>T	c.(1765-1767)GGC>GGT	p.G589G	CFB_uc011dor.1_Silent_p.G1091G	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	589	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						TGAAATATGGCCAGACTATCA	0.483													4	149					0	0	0	0	T	31918538	T	T	31918538	2	4	51	1	0	0	0	0	0	0	0	1	3293	726	26	4		4	CFB	6	31918538	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	3584568	31918538	139196529	65	10187											
GPR115	221393	broad.mit.edu	37	chr6	47663898	47663899	+	5'Flank	DEL	CT	-	-																															cttcttccctccctccctccCtctctctctctctttctccc																										TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr6:47663898_47663899delCT	uc003oza.1	+						GPR115_uc003oyz.1_Intron|GPR115_uc003ozb.1_5'Flank	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						ccctccctccctctctctctct	0.045													---	---	---								-	47663899	-	-	47663898	6	5	51	0	1	1	0	1	0	0	0	0	6670	696	24	0		0	GPR115	6	47663898	5'Flank	DEL	CT	TCGA-CN-4740-01A-01D-1434-08	15745360	47663898	123451169	66	10188											
C6orf165	154313	broad.mit.edu	37	chr6	88127960	88127960	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtagcaatcccagccacCatgcagcatattgattacca	13	9	6	13	0	0	1	0	1	0	0	1	1	1	1	4	0	5	4	4	0	4	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr6:88127960C>T	uc003plv.2	+	7	758	c.666C>T	c.(664-666)ACC>ACT	p.T222T	C6orf165_uc003plw.2_Silent_p.T34T|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Silent_p.T222T	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	222										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TCCCAGCCACCATGCAGCATA	0.493													11	89					0	0	0	0	T	88127960	T	T	88127960	2	4	51	1	0	0	0	0	0	0	0	1	2351	581	21	4		4	C6orf165	6	88127960	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	40464062	88127960	82987107	67	10189											
MDN1	23195	broad.mit.edu	37	chr6	90387317	90387317	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctcctgagtgctgctgaCgatggacaatgcgctctgga	8	9	13	11	2	1	2	0	2	1	0	2	5	2	4	2	2	4	3	2	2	1	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr6:90387317C>T	uc003pnn.1	-	76	12627	c.12511G>A	c.(12511-12513)GTC>ATC	p.V4171I		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4171					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTGCTGCTGACGATGGACAAT	0.433													19	113					0	0	0	0	T	90387317	T	T	90387317	3	4	51	1	0	0	0	0	1	0	0	0	9468	536	19	1	4387	1	MDN1	6	90387317	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	2259357	90387317	80727750	68	10190											
FGFR1OP	11116	broad.mit.edu	37	chr6	167427050	167427050	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagcgggcagaaggctggtGacaaggtaacatgcatgagg	13	5	16	7	1	0	3	0	2	0	1	0	3	0	3	0	5	3	4	0	5	4	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr6:167427050G>A	uc003qvj.2	+	7	659	c.574G>A	c.(574-576)GAC>AAC	p.D192N	CCR6_uc003qvl.2_Intron|FGFR1OP_uc011egp.1_Intron|FGFR1OP_uc003qvk.2_Intron	NM_007045	NP_008976	O95684	FR1OP_HUMAN	FGFR1 oncogene partner isoform a	192					G2/M transition of mitotic cell cycle|microtubule anchoring|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation	centrosome|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity|protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(1)	1		Breast(66;1.48e-05)|Ovarian(120;0.0607)		OV - Ovarian serous cystadenocarcinoma(33;1.73e-19)|BRCA - Breast invasive adenocarcinoma(81;5.1e-06)|GBM - Glioblastoma multiforme(31;0.00231)		GAAGGCTGGTGACAAGGTAAC	0.488			T	FGFR1	MPD|NHL								6	97					0	0	0	0	A	167427050	A	A	167427050	3	1	51	1	0	0	0	0	1	0	0	0	5896	1290	45	2	600	2	FGFR1OP	6	167427050	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	77039733	167427050	3688017	69	10191											
TMEM195	392636	broad.mit.edu	37	chr7	15427042	15427042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctatttacctctggaatttCttcactgagaccaagtcttg	9	16	6	10	0	5	1	1	1	4	1	5	3	5	2	2	1	1	0	2	1	4	6			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:15427042C>T	uc003stb.1	-	9	1116	c.946G>A	c.(946-948)GAA>AAA	p.E316K		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	316					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TCTGGAATTTCTTCACTGAGA	0.338													17	256					0	0	0	0	T	15427042	T	T	15427042	3	4	51	1	0	0	0	0	1	0	0	0	16183	922	32	2	411	2	TMEM195	7	15427042	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08		15427042	143711621	70	10192											
TXNDC3	51314	broad.mit.edu	37	chr7	37916515	37916515	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctaatgttgctaagttcatGgatgctttcttccccgattt	7	17	8	9	1	2	0	1	0	1	0	3	2	3	1	2	1	2	5	2	1	2	7			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:37916515G>C	uc003tfn.2	+	12	1272	c.900G>C	c.(898-900)ATG>ATC	p.M300I		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	300					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						CTAAGTTCATGGATGCTTTCT	0.353									Kartagener_syndrome				7	72					0	0	0	0	C	37916515	C	C	37916515	3	2	51	1	0	0	0	0	1	0	0	0	16866	1348	47	4	938	4	TXNDC3	7	37916515	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	22489473	37916515	121222148	71	10193											
HEPACAM2	253012	broad.mit.edu	37	chr7	92838082	92838082	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtaggtgttggggggatGagaatcagcagaacaatcaa	14	7	16	4	0	2	2	2	1	0	2	2	5	2	4	0	5	2	3	0	5	5	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:92838082G>T	uc003umm.2	-	4	846	c.823C>A	c.(823-825)CAT>AAT	p.H275N	HEPACAM2_uc003uml.2_Missense_Mutation_p.H263N|HEPACAM2_uc010lff.2_Missense_Mutation_p.H263N|HEPACAM2_uc011khy.1_Missense_Mutation_p.H298N	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	275	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						TTGGGGGGATGAGAATCAGCA	0.433													18	412					1.99824e-07	2.17718e-07	1	0	T	92838082	T	T	92838082	3	4	51	1	0	0	0	0	1	0	0	0	7092	1290	45	2	593	2	HEPACAM2	7	92838082	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	54921567	92838082	66300581	72	10194											
TRRAP	8295	broad.mit.edu	37	chr7	98608706	98608706	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catcctcaaggaggttcagaGtaacatggtgccgcgcagca	11	7	12	11	2	2	1	2	0	0	1	3	2	3	2	2	3	3	4	2	3	2	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:98608706G>A	uc003upp.2	+	70	11137	c.10928G>A	c.(10927-10929)AGT>AAT	p.S3643N	TRRAP_uc011kis.1_Missense_Mutation_p.S3614N|TRRAP_uc003upr.2_Missense_Mutation_p.S3349N|TRRAP_uc003ups.2_5'Flank	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3643	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GAGGTTCAGAGTAACATGGTG	0.527													24	50					0	0	0	0	A	98608706	A	A	98608706	3	1	51	1	0	0	0	0	1	0	0	0	16668	1029	36	4	11111	4	TRRAP	7	98608706	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	5770624	98608706	60529957	73	10195											
TAF6	6878	broad.mit.edu	37	chr7	99707583	99707583	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagtcaccagcaggaggctCtgcacatggtctgctccaat	9	9	10	13	0	4	0	2	0	2	0	5	1	5	1	2	3	3	4	2	3	1	0	rs145206628		TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:99707583C>T	uc003uti.2	-	12	1353	c.1272G>A	c.(1270-1272)CAG>CAA	p.Q424Q	AP4M1_uc003utd.2_Intron|TAF6_uc003utg.2_Silent_p.Q346Q|TAF6_uc003uth.2_Silent_p.Q481Q|TAF6_uc003utk.2_Silent_p.Q424Q|TAF6_uc011kji.1_Silent_p.Q461Q|TAF6_uc003utj.2_Silent_p.Q414Q|TAF6_uc003utl.2_Silent_p.Q424Q|TAF6_uc003utm.2_Silent_p.Q424Q	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	424					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCAGGAGGCTCTGCACATGGT	0.572													19	166					0	0	0	0	T	99707583	T	T	99707583	2	4	51	1	0	0	0	0	0	0	0	1	15596	912	32	2		2	TAF6	7	99707583	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	1098877	99707583	59431080	74	10196			1	15		5	5	4194	N	G_C	1.473846e-08
TAF6	6878	broad.mit.edu	37	chr7	99711299	99711299	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgatgatgtcgctcagatCaacctccttctcctcataga	10	13	6	12	1	4	4	3	2	1	2	7	4	5	4	3	0	1	1	3	0	2	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:99711299C>T	uc003uti.2	-	4	418	c.337G>A	c.(337-339)GAT>AAT	p.D113N	TAF6_uc003utg.2_Missense_Mutation_p.D54N|TAF6_uc003uth.2_Missense_Mutation_p.D170N|TAF6_uc003utk.2_Missense_Mutation_p.D113N|TAF6_uc011kji.1_Missense_Mutation_p.D150N|TAF6_uc003utj.2_Missense_Mutation_p.D103N|TAF6_uc003utl.2_Missense_Mutation_p.D113N|TAF6_uc003utm.2_Missense_Mutation_p.D113N|TAF6_uc003utn.1_Intron	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	113					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCGCTCAGATCAACCTCCTTC	0.607													24	177					0	0	0	0	T	99711299	T	T	99711299	3	4	51	1	0	0	0	0	1	0	0	0	15596	826	29	2	1744	2	TAF6	7	99711299	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	3716	99711299	59427364	75	10197			1	15		5	5	4194	N	G_C	1.473846e-08
TAF6	6878	broad.mit.edu	37	chr7	99711569	99711569	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccccatgtgcatgaacttCaaggcatcctggggtcggtg	7	11	12	11	1	1	1	1	1	0	0	4	1	3	1	3	4	2	2	3	4	2	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:99711569C>T	uc003uti.2	-	3	246	c.165G>A	c.(163-165)TTG>TTA	p.L55L	TAF6_uc003utg.2_5'UTR|TAF6_uc003uth.2_Silent_p.L112L|TAF6_uc003utk.2_Silent_p.L55L|TAF6_uc011kji.1_Silent_p.L92L|TAF6_uc003utj.2_Silent_p.L45L|TAF6_uc003utl.2_Silent_p.L55L|TAF6_uc003utm.2_Silent_p.L55L|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	55					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCATGAACTTCAAGGCATCCT	0.557													19	117					0	0	0	0	T	99711569	T	T	99711569	2	4	51	1	0	0	0	0	0	0	0	1	15596	825	29	2		2	TAF6	7	99711569	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	270	99711569	59427094	76	10198			1	15		5	5	4194	N	G_C	1.473846e-08
TAF6	6878	broad.mit.edu	37	chr7	99711749	99711749	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctcctcctgaatctgggcGatgcccatggattcagccac	7	10	10	14	1	3	1	1	1	2	0	5	3	4	2	4	2	2	0	4	2	1	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:99711749G>A	uc003uti.2	-	2	165	c.84C>T	c.(82-84)ATC>ATT	p.I28I	TAF6_uc003utg.2_5'Flank|TAF6_uc003uth.2_Silent_p.I85I|TAF6_uc003utk.2_Silent_p.I28I|TAF6_uc011kji.1_Silent_p.I65I|TAF6_uc003utj.2_Silent_p.I28I|TAF6_uc003utl.2_Silent_p.I28I|TAF6_uc003utm.2_Silent_p.I28I|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	28					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAATCTGGGCGATGCCCATGG	0.567													31	173					0	0	0	0	A	99711749	A	A	99711749	2	1	51	1	0	0	0	0	0	0	0	1	15596	1048	37	1		1	TAF6	7	99711749	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	180	99711749	59426914	77	10199			1	15		5	5	4194	N	G_C	1.473846e-08
TAF6	6878	broad.mit.edu	37	chr7	99711776	99711776	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggattcagccaccaccttCatggactccgagggcagcac	10	7	10	14	1	2	0	2	0	0	0	3	3	3	2	4	3	2	2	4	3	0	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:99711776C>T	uc003uti.2	-	2	138	c.57G>A	c.(55-57)ATG>ATA	p.M19I	TAF6_uc003utg.2_5'Flank|TAF6_uc003uth.2_Missense_Mutation_p.M76I|TAF6_uc003utk.2_Missense_Mutation_p.M19I|TAF6_uc011kji.1_Missense_Mutation_p.M56I|TAF6_uc003utj.2_Missense_Mutation_p.M19I|TAF6_uc003utl.2_Missense_Mutation_p.M19I|TAF6_uc003utm.2_Missense_Mutation_p.M19I|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	19					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCACCACCTTCATGGACTCCG	0.572													29	181					0	0	0	0	T	99711776	T	T	99711776	3	4	51	1	0	0	0	0	1	0	0	0	15596	826	29	2	2032	2	TAF6	7	99711776	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	27	99711776	59426887	78	10200			1	15		5	5	4194	N	G_C	1.473846e-08
RELN	5649	broad.mit.edu	37	chr7	103191542	103191542	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcagcttcccaaagtgcaCgacctccctcctccagccct	7	8	7	19	1	0	0	0	0	0	0	4	1	4	0	6	0	4	3	6	0	1	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:103191542C>T	uc003vca.2	-	41	6434	c.6274G>A	c.(6274-6276)GTG>ATG	p.V2092M	RELN_uc010liz.2_Missense_Mutation_p.V2092M	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2092					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCAAAGTGCACGACCTCCCTC	0.552													9	54					0	0	0	0	T	103191542	T	T	103191542	3	4	51	1	0	0	0	0	1	0	0	0	13285	536	19	1	4208	1	RELN	7	103191542	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	3479766	103191542	55947121	79	10201											
SRPK2	6733	broad.mit.edu	37	chr7	104782508	104782509	+	Frame_Shift_Ins	INS	-	A	A																															cgttctgcttctgtcatgggINSatggactgctctcctcttgc																								rs56112661		TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:104782508_104782509insA	uc003vct.2	-	10	1643_1644	c.1456_1457insT	c.(1456-1458)TCCfs	p.S486fs	SRPK2_uc003vcu.2_Frame_Shift_Ins_p.S486fs|SRPK2_uc003vcv.2_Frame_Shift_Ins_p.S497fs|SRPK2_uc003vcw.1_Frame_Shift_Ins_p.S486fs	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	486	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TCTGTCATGGGATGGACTGCTC	0.52													---	---	---								A	104782509	A	A	104782508	7	5	51	1	0	1	1	0	0	0	0	0	15226	1174	41	0	633	0	SRPK2	7	104782508	Frame_Shift_Ins	INS	-	TCGA-CN-4740-01A-01D-1434-08	1590966	104782508	54356155	80	10202											
LAMB4	22798	broad.mit.edu	37	chr7	107710183	107710183	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatgcagcttggcagacaTgctgatgatcagcctttcac	10	11	9	11	0	3	3	3	2	0	1	3	3	3	3	1	1	4	4	1	1	0	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:107710183T>A	uc010ljo.1	-	18	2356	c.2272A>T	c.(2272-2274)ATG>TTG	p.M758L	LAMB4_uc003vey.2_Missense_Mutation_p.M758L	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	758	Laminin IV type B.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TTGGCAGACATGCTGATGATC	0.478													36	148					0	0	0	0	A	107710183	A	A	107710183	3	1	51	1	0	0	0	0	1	0	0	0	8653	1464	51	5	3081	5	LAMB4	7	107710183	Missense_Mutation	SNP	T	TCGA-CN-4740-01A-01D-1434-08	2927675	107710183	51428480	81	10203											
ACTR3C	653857	broad.mit.edu	37	chr7	149981865	149981865	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atacagcggacgccgcacatCgatggggcagttctgtatta	10	9	12	10	4	1	0	0	0	1	0	2	2	1	1	1	3	2	4	1	3	3	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:149981865C>T	uc003wgu.1	-	6	731	c.541G>A	c.(541-543)GAT>AAT	p.D181N		NM_001040135	NP_001035225	Q9C0K3	ARP3C_HUMAN	actin-related protein 3-beta isoform 2	181					regulation of actin filament polymerization	cytoskeleton	actin binding|ATP binding				0						CGCCGCACATCGATGGGGCAG	0.398													6	45					0	0	0	0	T	149981865	T	T	149981865	3	4	51	1	0	0	0	0	1	0	0	0	214	884	31	1	99	1	ACTR3C	7	149981865	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	42271682	149981865	9156798	82	10204											
GIMAP6	474344	broad.mit.edu	37	chr7	150325563	150325563	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccccatgagaatgagcctCagtctccttggggtcttctg	6	13	10	12	0	4	2	1	2	3	1	6	3	5	2	4	2	1	0	4	2	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr7:150325563C>A	uc003whn.2	-	3	547	c.123G>T	c.(121-123)CTG>CTT	p.L41L	GIMAP6_uc003whm.2_Intron	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	41							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAATGAGCCTCAGTCTCCTTG	0.517													61	680					5.96624e-29	6.91327e-29	1	0	A	150325563	A	A	150325563	2	1	51	1	0	0	0	0	0	0	0	1	6420	813	29	2		2	GIMAP6	7	150325563	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	343698	150325563	8813100	83	10205											
COL14A1	7373	broad.mit.edu	37	chr8	121228727	121228727	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagatgggactgaaatcaatGaggtaagttccgggacataa	15	8	12	6	1	1	3	1	2	0	1	2	5	2	5	1	3	0	2	1	3	4	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr8:121228727G>A	uc003yox.2	+	14	2000	c.1735G>A	c.(1735-1737)GAG>AAG	p.E579K	COL14A1_uc003yoy.2_Missense_Mutation_p.E257K|COL14A1_uc010mde.1_Missense_Mutation_p.E257K	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	579	Fibronectin type-III 4.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGAAATCAATGAGGTAAGTTC	0.284													8	211					0	0	0	0	A	121228727	A	A	121228727	3	1	51	1	0	0	0	0	1	0	0	0	3686	1291	45	2	1785	2	COL14A1	8	121228727	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08		121228727	25135295	84	10206											
COL14A1	7373	broad.mit.edu	37	chr8	121243789	121243789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatgggacatttctgacagcGatgtgcagcagtttagggtg	10	11	14	6	1	1	1	0	1	1	0	1	3	1	2	0	2	3	3	0	2	2	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr8:121243789G>A	uc003yox.2	+	19	2546	c.2281G>A	c.(2281-2283)GAT>AAT	p.D761N	COL14A1_uc003yoy.2_Missense_Mutation_p.D439N	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	761	Fibronectin type-III 6.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TTCTGACAGCGATGTGCAGCA	0.453													10	121					0	0	0	0	A	121243789	A	A	121243789	3	1	51	1	0	0	0	0	1	0	0	0	3686	1058	37	1	2351	1	COL14A1	8	121243789	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	15062	121243789	25120233	85	10207											
MAPK15	225689	broad.mit.edu	37	chr8	144803252	144803252	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtccagctctctgtgcctGagtaccgcagccgcgtctat	5	10	12	14	3	2	1	0	1	2	0	4	1	3	1	4	1	4	3	4	1	2	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr8:144803252G>C	uc003yzj.2	+	10	1041	c.1000G>C	c.(1000-1002)GAG>CAG	p.E334Q		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	334					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTCTGTGCCTGAGTACCGCAG	0.652													4	32					0	0	0	0	C	144803252	C	C	144803252	3	2	51	1	0	0	0	0	1	0	0	0	9330	1291	45	2	1038	2	MAPK15	8	144803252	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	23559463	144803252	1560770	86	10208											
PLEC	5339	broad.mit.edu	37	chr8	144991144	144991144	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcgtctccgtgtccaggatgCcagccacggggcccgtctcc	4	7	13	17	4	2	0	0	0	2	0	5	1	3	1	6	3	2	0	6	3	0	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr8:144991144C>T	uc003zaf.1	-	32	13426	c.13256G>A	c.(13255-13257)GGC>GAC	p.G4419D	PLEC_uc003zab.1_Missense_Mutation_p.G4282D|PLEC_uc003zac.1_Missense_Mutation_p.G4286D|PLEC_uc003zad.2_Missense_Mutation_p.G4282D|PLEC_uc003zae.1_Missense_Mutation_p.G4250D|PLEC_uc003zag.1_Missense_Mutation_p.G4260D|PLEC_uc003zah.2_Missense_Mutation_p.G4268D|PLEC_uc003zaj.2_Missense_Mutation_p.G4309D	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4419	Globular 2.|Plectin 29.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTCCAGGATGCCAGCCACGGG	0.672													4	110					0	0	0	0	T	144991144	T	T	144991144	3	4	51	1	0	0	0	0	1	0	0	0	12107	739	26	4	802	4	PLEC	8	144991144	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	187892	144991144	1372878	87	10209											
FREM1	158326	broad.mit.edu	37	chr9	14824903	14824903	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttagttatataggccacctCagtttccttgacaaccaaat	12	13	5	11	0	1	1	1	1	0	0	2	1	2	1	4	1	1	2	4	1	6	6			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr9:14824903C>T	uc003zlm.2	-	11	2559	c.1969G>A	c.(1969-1971)GAG>AAG	p.E657K	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	657	CSPG 4.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TAGGCCACCTCAGTTTCCTTG	0.408													10	65					0	0	0	0	T	14824903	T	T	14824903	3	4	51	1	0	0	0	0	1	0	0	0	6078	835	29	2	4728	2	FREM1	9	14824903	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08		14824903	126388528	88	10210											
TMEM2	23670	broad.mit.edu	37	chr9	74365204	74365204	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaatgggacaaccttccctGgaacatagccagatgggtga	12	7	12	10	0	0	2	0	1	0	1	1	4	1	4	3	3	3	1	3	3	4	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr9:74365204G>A	uc011lsa.1	-	2	626	c.86C>T	c.(85-87)CCA>CTA	p.P29L	TMEM2_uc010mos.2_Missense_Mutation_p.P29L|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	29						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AACCTTCCCTGGAACATAGCC	0.517													15	88					0	0	0	0	A	74365204	A	A	74365204	3	1	51	1	0	0	0	0	1	0	0	0	16187	1348	47	4	4157	4	TMEM2	9	74365204	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	59540301	74365204	66848227	89	10211											
GDA	9615	broad.mit.edu	37	chr9	74828816	74828816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttacagataaatttggacagCgggcatttgtgggcaaagtt	12	12	12	5	1	0	1	0	0	0	1	0	2	0	2	0	3	2	3	0	3	4	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr9:74828816C>T	uc004aiq.2	+	5	670	c.487C>T	c.(487-489)CGG>TGG	p.R163W	GDA_uc011lse.1_Missense_Mutation_p.R89W|GDA_uc011lsf.1_Missense_Mutation_p.R89W|GDA_uc004air.2_Missense_Mutation_p.R163W|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Missense_Mutation_p.R121W|GDA_uc004ait.1_Missense_Mutation_p.R89W	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	163					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		ATTTGGACAGCGGGCATTTGT	0.328													14	55					0	0	0	0	T	74828816	T	T	74828816	3	4	51	1	0	0	0	0	1	0	0	0	6342	759	27	1	505	1	GDA	9	74828816	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	463612	74828816	66384615	90	10212											
RBM17	84991	broad.mit.edu	37	chr10	6139143	6139143	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagaaggcagctctcactCaggcaaaggtaaagacaagc	16	5	11	9	0	2	3	2	1	1	2	3	3	2	3	0	3	2	4	0	3	6	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr10:6139143C>T	uc001ijb.2	+	2	341	c.115C>T	c.(115-117)CAG>TAG	p.Q39*	RBM17_uc010qav.1_Nonsense_Mutation_p.Q39*	NM_032905	NP_116294	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	39					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						AGCTCTCACTCAGGCAAAGGT	0.493													12	112					0	0	0	0	T	6139143	T	T	6139143	4	4	51	1	0	0	0	0	0	1	0	0	13184	827	29	2	117	2	RBM17	10	6139143	Nonsense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08		6139143	129395604	91	10213											
ANKRD26	22852	broad.mit.edu	37	chr10	27323939	27323939	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcatcatccagttgttgtCgaagcaacatattctcactt	10	13	8	10	1	2	0	2	0	1	0	5	1	3	0	1	1	2	4	1	1	3	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr10:27323939C>T	uc001ith.2	-	24	3609	c.3437G>A	c.(3436-3438)CGA>CAA	p.R1146Q	ANKRD26_uc001itg.2_Missense_Mutation_p.R833Q|ANKRD26_uc009xku.1_Missense_Mutation_p.R1147Q	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1146	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						CAGTTGTTGTCGAAGCAACAT	0.368													29	311					0	0	0	0	T	27323939	T	T	27323939	3	4	51	1	0	0	0	0	1	0	0	0	654	884	31	1	1736	1	ANKRD26	10	27323939	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	21184796	27323939	108210808	92	10214											
BICC1	80114	broad.mit.edu	37	chr10	60558291	60558291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagccccacattatgggcacCcccacttgctaatacttcaa	11	9	5	16	0	1	0	1	0	0	0	1	0	1	0	4	1	3	2	4	1	4	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr10:60558291C>T	uc001jki.1	+	11	1499	c.1499C>T	c.(1498-1500)CCC>CTC	p.P500L	BICC1_uc001jkj.1_Missense_Mutation_p.P141L	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	500					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						TTATGGGCACCCCCACTTGCT	0.403													14	183					0	0	0	0	T	60558291	T	T	60558291	3	4	51	1	0	0	0	0	1	0	0	0	1430	623	22	4	1541	4	BICC1	10	60558291	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	33234352	60558291	74976456	93	10215											
HK1	3098	broad.mit.edu	37	chr10	71142518	71142518	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgtggttaagatgctgccctCcttcgtccggagaactcccg	6	10	11	14	4	0	2	0	0	0	2	4	3	3	2	4	2	3	2	4	2	2	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr10:71142518C>T	uc001jpl.3	+	10	1642	c.1541C>T	c.(1540-1542)TCC>TTC	p.S514F	HK1_uc001jpg.3_Missense_Mutation_p.S502F|HK1_uc001jph.3_Missense_Mutation_p.S518F|HK1_uc001jpi.3_Missense_Mutation_p.S518F|HK1_uc001jpj.3_Missense_Mutation_p.S549F|HK1_uc001jpk.3_Missense_Mutation_p.S513F|HK1_uc009xqd.2_Missense_Mutation_p.S392F	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	514	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						ATGCTGCCCTCCTTCGTCCGG	0.632													3	28					0	0	0	0	T	71142518	T	T	71142518	3	4	51	1	0	0	0	0	1	0	0	0	7229	855	30	2	1757	2	HK1	10	71142518	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	10584227	71142518	64392229	94	10216											
FAM22A	728118	broad.mit.edu	37	chr10	88988216	88988216	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgacagaacaggatggctgCggcccgagtggggccggggc	7	4	20	10	3	0	2	0	1	0	1	0	4	0	3	2	7	2	1	2	7	1	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr10:88988216C>T	uc001kek.2	+	2	962	c.579C>T	c.(577-579)TGC>TGT	p.C193C	LOC728190_uc009xtc.2_Intron|LOC728190_uc009xtd.2_Intron	NM_001099338	NP_001092808	Q8IVF1	FA22A_HUMAN	hypothetical protein LOC728118	193											0						AGGATGGCTGCGGCCCGAGTG	0.657													17	171					0	0	0	0	T	88988216	T	T	88988216	2	4	51	1	0	0	0	0	0	0	0	1	5571	776	27	1		1	FAM22A	10	88988216	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	17845698	88988216	46546531	95	10217											
MYOF	26509	broad.mit.edu	37	chr10	95134520	95134521	+	Frame_Shift_Ins	INS	-	T	T																															tgtagtttaaaagtcctaccINStcttcagtcagctgcattaa																										TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr10:95134520_95134521insT	uc001kin.2	-	23	2423_2424	c.2300_2301insA	c.(2299-2301)GAGfs	p.E767fs	MYOF_uc001kio.2_Frame_Shift_Ins_p.E754fs|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	767	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						AAAGTCCTACCTCTTCAGTCAG	0.455													---	---	---								T	95134521	T	T	95134520	7	5	51	1	0	1	1	0	0	0	0	0	10142	695	24	0	4012	0	MYOF	10	95134520	Frame_Shift_Ins	INS	-	TCGA-CN-4740-01A-01D-1434-08	6146304	95134520	40400227	96	10218											
ERLIN1	10613	broad.mit.edu	37	chr10	101914691	101914691	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttctctcgggccaggaatgCagcatctagcaaataaacaa	14	9	8	10	1	2	0	0	0	2	0	4	1	2	1	1	2	4	3	1	2	6	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr10:101914691C>T	uc001kqn.3	-	10	1102	c.751G>A	c.(751-753)GCA>ACA	p.A251T	ERLIN1_uc001kqm.3_Missense_Mutation_p.A16T|ERLIN1_uc001kqo.3_Missense_Mutation_p.A251T|ERLIN1_uc010qpm.1_Missense_Mutation_p.A167T	NM_006459	NP_006450	O75477	ERLN1_HUMAN	ER lipid raft associated 1	249	Lumenal (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding				0		Colorectal(252;0.234)		Epithelial(162;3.85e-10)|all cancers(201;3.25e-08)		GCCAGGAATGCAGCATCTAGC	0.453													6	53					0	0	0	0	T	101914691	T	T	101914691	3	4	51	1	0	0	0	0	1	0	0	0	5256	710	25	4	303	4	ERLIN1	10	101914691	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	6780171	101914691	33620056	97	10219											
SEC23IP	11196	broad.mit.edu	37	chr10	121658241	121658241	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatgggaataaattcttatCtgccttctcagccaagtagt	11	14	8	8	0	3	1	1	1	3	0	4	2	3	2	2	1	2	1	2	1	6	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr10:121658241C>G	uc001leu.1	+	2	538	c.466C>G	c.(466-468)CTG>GTG	p.L156V	SEC23IP_uc010qtc.1_Intron	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	156	Interaction with SEC23A.|Pro-rich.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		AAATTCTTATCTGCCTTCTCA	0.478													21	208					0	0	0	0	G	121658241	G	G	121658241	3	3	51	1	0	0	0	0	1	0	0	0	14058	912	32	2	472	2	SEC23IP	10	121658241	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	19743550	121658241	13876506	98	10220											
PPP2R2D	55844	broad.mit.edu	37	chr10	133753685	133753685	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacagaatgctgctcattttCtactgtctacaaatggtaag	13	13	7	8	0	3	1	1	0	2	1	3	1	3	1	0	1	5	3	0	1	6	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr10:133753685C>G	uc001lks.2	+	2	493	c.250C>G	c.(250-252)CTA>GTA	p.L84V	PPP2R2D_uc001lkr.2_5'UTR|PPP2R2D_uc001lkt.2_5'UTR|PPP2R2D_uc009yay.2_5'UTR	NM_018461	NP_060931	Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B,	117	WD 2.				cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			skin(1)	1		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		TGCTCATTTTCTACTGTCTAC	0.299													6	36					0	0	0	0	G	133753685	G	G	133753685	3	3	51	1	0	0	0	0	1	0	0	0	12447	912	32	2	257	2	PPP2R2D	10	133753685	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	12095444	133753685	1781062	99	10221											
TRPM5	29850	broad.mit.edu	37	chr11	2434717	2434717	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcacccacctgaaggtgatGaggttggtatagacgagggc	10	8	14	9	1	1	4	1	3	0	1	1	5	1	4	2	4	0	2	2	4	3	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr11:2434717G>A	uc001lwm.3	-	13	2001	c.1992C>T	c.(1990-1992)CTC>CTT	p.L664L	TRPM5_uc010qxl.1_Silent_p.L664L|TRPM5_uc009ydn.2_Silent_p.L666L	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	664	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGAAGGTGATGAGGTTGGTAT	0.682													5	17					0	0	0	0	A	2434717	A	A	2434717	2	1	51	1	0	0	0	0	0	0	0	1	16656	1277	45	2		2	TRPM5	11	2434717	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08		2434717	132571799	100	10222											
SWAP70	23075	broad.mit.edu	37	chr11	9750966	9750966	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttttgaaatcagtgcttCagataagaagaagaaacagg	17	9	10	5	0	2	5	2	1	0	4	2	6	2	5	0	1	2	1	0	1	5	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr11:9750966C>T	uc001mhw.2	+	6	965	c.866C>T	c.(865-867)TCA>TTA	p.S289L	SWAP70_uc001mhv.2_Missense_Mutation_p.S289L|SWAP70_uc001mhx.2_Missense_Mutation_p.S231L	NM_015055	NP_055870	Q9UH65	SWP70_HUMAN	SWAP-70 protein	289	PH.					cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			ovary(2)|central_nervous_system(1)	3				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		ATCAGTGCTTCAGATAAGAAG	0.299													7	75					0	0	0	0	T	9750966	T	T	9750966	3	4	51	1	0	0	0	0	1	0	0	0	15491	838	29	2	888	2	SWAP70	11	9750966	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	7316249	9750966	125255550	101	10223											
OR5J2	282775	broad.mit.edu	37	chr11	55944190	55944190	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgctttttgtggtgttcctgGtgatttacgccattaccttg	4	19	10	8	1	0	1	0	1	0	0	1	1	1	1	3	2	3	2	3	2	2	7			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr11:55944190G>A	uc010rjb.1	+	1	97	c.97G>A	c.(97-99)GTG>ATG	p.V33M		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					GGTGTTCCTGGTGATTTACGC	0.403													64	284					0	0	0	0	A	55944190	A	A	55944190	3	1	51	1	0	0	0	0	1	0	0	0	11219	1261	44	4	99	4	OR5J2	11	55944190	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	46193224	55944190	79062326	102	10224											
GIF	2694	broad.mit.edu	37	chr11	59603454	59603454	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggggccagggccagggttGctgggtagagttggttgtac	5	10	20	6	0	0	1	0	0	0	1	0	1	0	1	2	6	2	6	2	6	2	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr11:59603454G>T	uc001noi.2	-	7	948	c.900C>A	c.(898-900)AGC>AGA	p.S300R		NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	300					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						GGCCAGGGTTGCTGGGTAGAG	0.473													23	245					7.07758e-08	7.74995e-08	1	0	T	59603454	T	T	59603454	3	4	51	1	0	0	0	0	1	0	0	0	6413	1310	46	4	365	4	GIF	11	59603454	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	3659264	59603454	75403062	103	10225											
TUT1	64852	broad.mit.edu	37	chr11	62358968	62358968	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccgccatagcgactctcCtgtaccgacaaaaacacaag	13	5	7	16	4	1	0	0	0	1	0	2	2	1	0	5	0	3	1	5	0	5	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr11:62358968C>T	uc001nto.2	-	1	142	c.104G>A	c.(103-105)AGG>AAG	p.R35K		NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	Error:Variant_position_missing_in_Q9H6E5_after_alignment					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						AGCGACTCTCCTGTACCGACA	0.602													11	29					0	0	0	0	T	62358968	T	T	62358968	3	4	51	1	0	0	0	0	1	0	0	0	16848	681	24	4	2670	4	TUT1	11	62358968	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	2755514	62358968	72647548	104	10226											
UCP2	7351	broad.mit.edu	37	chr11	73689376	73689376	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgtgccagccccaagaaaCttcacagtggcagtaggggg	10	6	14	11	0	1	1	1	0	0	1	1	1	1	1	3	3	3	3	3	3	3	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr11:73689376C>A	uc001oup.1	-	3	428	c.48G>T	c.(46-48)AAG>AAT	p.K16N	UCP2_uc001ouq.1_Missense_Mutation_p.K16N	NM_003355	NP_003346	P55851	UCP2_HUMAN	uncoupling protein 2	16	Helical; Name=1; (Potential).|Solcar 1.				proton transport|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding				0	Breast(11;0.000112)					CCCCAAGAAACTTCACAGTGG	0.547													19	63					1.96292e-10	2.19327e-10	1	0	A	73689376	A	A	73689376	3	1	51	1	0	0	0	0	1	0	0	0	16999	564	20	4	905	4	UCP2	11	73689376	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	11330408	73689376	61317140	105	10227											
GRIN2B	2904	broad.mit.edu	37	chr12	13906692	13906692	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcccacaaagctattctcaAtggtgctgcggatcttgttt	9	13	9	10	1	2	0	1	0	2	0	3	1	2	1	1	2	4	3	1	2	3	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:13906692A>G	uc001rbt.2	-	3	748	c.569T>C	c.(568-570)ATT>ACT	p.I190T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	190	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCTATTCTCAATGGTGCTGCG	0.463													39	125					0	0	0	0	G	13906692	G	G	13906692	3	3	51	1	0	0	0	0	1	0	0	0	6819	101	4	5	3929	5	GRIN2B	12	13906692	Missense_Mutation	SNP	A	TCGA-CN-4740-01A-01D-1434-08		13906692	119945203	106	10228											
CCDC91	55297	broad.mit.edu	37	chr12	28410061	28410061	+	5'Flank	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacaaataaatatgtatacAtttaagttggagagtatttt	16	17	6	2	0	0	1	0	0	0	1	0	2	0	1	0	1	2	3	0	1	9	11	rs76960133	byFrequency	TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:28410061A>G	uc001riq.2	+						CCDC91_uc001rio.2_Intron|CCDC91_uc009zjk.2_Intron|CCDC91_uc001rip.1_5'UTR	NM_018318	NP_060788	Q7Z6B0	CCD91_HUMAN	GGA binding partner						protein transport	Golgi apparatus|membrane				central_nervous_system(1)	1	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					ATATGTATACATTTAAGTTGG	0.299													12	134					0	0	0	0	G	28410061	G	G	28410061	1	3	51	0	1	0	0	0	0	0	0	0	2883	232	8	5		5	CCDC91	12	28410061	5'Flank	SNP	A	TCGA-CN-4740-01A-01D-1434-08	14503369	28410061	105441834	107	10229											
KIF21A	55605	broad.mit.edu	37	chr12	39696848	39696848	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aataggttatccccttgaatGgttagtgcttctatgccatc	9	15	8	9	0	1	1	0	1	1	0	3	1	2	1	3	2	2	3	3	2	6	6			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:39696848G>A	uc001rly.2	-	36	4796	c.4650C>T	c.(4648-4650)ACC>ACT	p.T1550T	KIF21A_uc001rlv.2_Silent_p.T495T|KIF21A_uc001rlw.2_Silent_p.T820T|KIF21A_uc001rlx.2_Silent_p.T1537T|KIF21A_uc001rlz.2_Silent_p.T1497T|KIF21A_uc010skl.1_Silent_p.T1513T|KIF21A_uc001rlt.2_Silent_p.T170T|KIF21A_uc001rlu.2_Silent_p.T170T	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1550	WD 5.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CCCCTTGAATGGTTAGTGCTT	0.403													5	172					0	0	0	0	A	39696848	A	A	39696848	2	1	51	1	0	0	0	0	0	0	0	1	8327	1335	47	4		4	KIF21A	12	39696848	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	11286787	39696848	94155047	108	10230											
SP1	6667	broad.mit.edu	37	chr12	53776257	53776258	+	Frame_Shift_Del	DEL	AT	-	-																															ctaatattcagtatcaagtaAtcccacagttccagaccgtt																										TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:53776257_53776258delAT	uc001scw.2	+	3	623_624	c.526_527delAT	c.(526-528)ATCfs	p.I176fs	SP1_uc010sog.1_Frame_Shift_Del_p.I169fs	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	176	Transactivation domain A (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		GTATCAAGTAATCCCACAGTTC	0.515													---	---	---								-	53776258	-	-	53776257	7	5	51	1	0	1	0	1	0	0	0	0	15023	101	4	0	536	0	SP1	12	53776257	Frame_Shift_Del	DEL	AT	TCGA-CN-4740-01A-01D-1434-08	14079409	53776257	80075638	109	10231											
GPR84	53831	broad.mit.edu	37	chr12	54757125	54757125	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggccggcctcggatgcggtCaaagctgcaggtgcagacta	9	6	15	11	3	1	1	1	0	0	1	2	2	1	2	2	5	4	3	2	5	2	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:54757125C>G	uc001sfu.2	-	2	601	c.511G>C	c.(511-513)GAC>CAC	p.D171H		NM_020370	NP_065103	Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	171	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)	2						CGGATGCGGTCAAAGCTGCAG	0.572													3	80					0	0	0	0	G	54757125	G	G	54757125	3	3	51	1	0	0	0	0	1	0	0	0	6752	826	29	2	683	2	GPR84	12	54757125	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	980868	54757125	79094770	110	10232											
RBMS2	5939	broad.mit.edu	37	chr12	56975652	56975652	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctatgaccccaccacagcTcttcagaatgggtaaggttt	11	10	8	12	0	2	2	1	1	1	1	2	2	2	2	4	2	1	3	4	2	3	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:56975652T>C	uc001sln.2	+	8	967	c.768T>C	c.(766-768)GCT>GCC	p.A256A	RBMS2_uc010sqp.1_Silent_p.A111A|RBMS2_uc010sqq.1_Silent_p.A131A|RBMS2_uc009zou.2_Silent_p.A13A	NM_002898	NP_002889	Q15434	RBMS2_HUMAN	RNA binding motif, single stranded interacting	256					RNA processing	nucleus	nucleotide binding|RNA binding				0						CCACCACAGCTCTTCAGAATG	0.433													51	264					0	0	0	0	C	56975652	C	C	56975652	2	2	51	1	0	0	0	0	0	0	0	1	13214	1538	54	5		5	RBMS2	12	56975652	Silent	SNP	T	TCGA-CN-4740-01A-01D-1434-08	2218527	56975652	76876243	111	10233											
SHMT2	6472	broad.mit.edu	37	chr12	57626045	57626045	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggatatcagccacgtccatCttcttcgagtctatgcccta	8	12	7	14	3	4	0	1	0	3	0	6	2	5	1	3	1	2	0	3	1	3	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:57626045C>G	uc001snf.1	+	5	574	c.564C>G	c.(562-564)ATC>ATG	p.I188M	SHMT2_uc001sng.1_Missense_Mutation_p.I84M|SHMT2_uc001snh.1_Missense_Mutation_p.I27M|SHMT2_uc009zpk.1_Missense_Mutation_p.I188M|SHMT2_uc001sni.1_Missense_Mutation_p.I167M|SHMT2_uc010srg.1_Missense_Mutation_p.I197M|SHMT2_uc001snj.1_Missense_Mutation_p.S83C|SHMT2_uc010srh.1_Missense_Mutation_p.I167M|SHMT2_uc001snk.1_Missense_Mutation_p.S83C|SHMT2_uc010sri.1_Missense_Mutation_p.I167M|SHMT2_uc001snl.2_Missense_Mutation_p.S83C|SHMT2_uc010srj.1_5'Flank	NM_005412	NP_005403	P34897	GLYM_HUMAN	serine hydroxymethyltransferase 2	188						microtubule cytoskeleton|mitochondrial nucleoid	glycine hydroxymethyltransferase activity|methyltransferase activity			ovary(1)|central_nervous_system(1)	2					Glycine(DB00145)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CCACGTCCATCTTCTTCGAGT	0.592													38	152					0	0	0	0	G	57626045	G	G	57626045	3	3	51	1	0	0	0	0	1	0	0	0	14351	903	32	2	582	2	SHMT2	12	57626045	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	650393	57626045	76225850	112	10234											
GLI1	2735	broad.mit.edu	37	chr12	57858619	57858619	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgcacatctccaggaggCtcctacggtcatctctccat	8	10	8	15	2	3	0	1	0	2	0	7	2	5	1	3	3	2	2	3	3	1	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:57858619C>T	uc001snx.2	+	4	435	c.357C>T	c.(355-357)GGC>GGT	p.G119G	GLI1_uc009zpp.2_RNA|GLI1_uc009zpq.2_5'UTR|GLI1_uc009zpr.1_RNA	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	119					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CTCCAGGAGGCTCCTACGGTC	0.587													22	123					0	0	0	0	T	57858619	T	T	57858619	2	4	51	1	0	0	0	0	0	0	0	1	6474	784	28	4		4	GLI1	12	57858619	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	232574	57858619	75993276	113	10235											
TMTC2	160335	broad.mit.edu	37	chr12	83359345	83359345	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttttccccctcagctgcatAtttaaataccggtattattc	9	16	4	12	1	1	0	1	0	0	0	3	0	2	0	3	1	3	3	3	1	6	9			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:83359345A>G	uc001szt.2	+	6	2123	c.1691A>G	c.(1690-1692)TAT>TGT	p.Y564C	TMTC2_uc001szr.1_Missense_Mutation_p.Y564C|TMTC2_uc001szs.1_Missense_Mutation_p.Y564C|TMTC2_uc010suk.1_Missense_Mutation_p.Y319C	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	564	TPR 4.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						TCAGCTGCATATTTAAATACC	0.368													14	108					0	0	0	0	G	83359345	G	G	83359345	3	3	51	1	0	0	0	0	1	0	0	0	16327	449	16	5	1713	5	TMTC2	12	83359345	Missense_Mutation	SNP	A	TCGA-CN-4740-01A-01D-1434-08	25500726	83359345	50492550	114	10236											
RASSF9	9182	broad.mit.edu	37	chr12	86198832	86198832	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcttttctccaaatcacacTtaacactctctaaattagag	13	14	3	11	0	3	1	1	0	2	1	5	1	3	1	1	0	2	1	1	0	5	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:86198832T>G	uc001taf.1	-	2	1295	c.956A>C	c.(955-957)AAG>ACG	p.K319T		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	319					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						CAAATCACACTTAACACTCTC	0.368													39	363					0	0	0	0	G	86198832	G	G	86198832	3	3	51	1	0	0	0	0	1	0	0	0	13158	1609	56	5	355	5	RASSF9	12	86198832	Missense_Mutation	SNP	T	TCGA-CN-4740-01A-01D-1434-08	2839487	86198832	47653063	115	10237											
C12orf48	55010	broad.mit.edu	37	chr12	102572458	102572458	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttttggacgaagaagcagCtaatgctcctaccaaaaaca	15	9	7	10	1	1	1	0	0	1	1	2	3	2	2	2	1	5	3	2	1	6	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr12:102572458C>G	uc001tjf.2	+	8	1206	c.1094C>G	c.(1093-1095)GCT>GGT	p.A365G	C12orf48_uc001tjg.2_Missense_Mutation_p.A284G|C12orf48_uc010swa.1_Missense_Mutation_p.A442G|C12orf48_uc001tjh.2_Missense_Mutation_p.A284G|C12orf48_uc010swb.1_Intron|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_Missense_Mutation_p.A80G|C12orf48_uc001tjk.2_Intron|C12orf48_uc009zud.2_Intron	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	365					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						GAAGAAGCAGCTAATGCTCCT	0.378													11	79					0	0	0	0	G	102572458	G	G	102572458	3	3	51	1	0	0	0	0	1	0	0	0	1698	797	28	4	873	4	C12orf48	12	102572458	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	16373626	102572458	31279437	116	10238											
SKA3	221150	broad.mit.edu	37	chr13	21742409	21742409	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatctgaaagttgtggactaCgtggagacttctcagaaata	14	11	10	6	1	2	3	1	1	2	2	3	5	2	4	0	2	1	1	0	2	5	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr13:21742409C>T	uc001unt.2	-	4	555	c.461G>A	c.(460-462)CGT>CAT	p.R154H	SKA3_uc001unv.2_Missense_Mutation_p.R72H|SKA3_uc001unu.2_Missense_Mutation_p.R154H	NM_145061	NP_659498	Q8IX90	SKA3_HUMAN	SKA3	154					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding				0						TTGTGGACTACGTGGAGACTT	0.433													21	167					0	0	0	0	T	21742409	T	T	21742409	3	4	51	1	0	0	0	0	1	0	0	0	14419	536	19	1	848	1	SKA3	13	21742409	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08		21742409	93427469	117	10239											
CDADC1	81602	broad.mit.edu	37	chr13	49833572	49833572	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacatgccgggcagattgctCttattaaacatgggtcaagg	11	11	11	8	1	2	1	1	0	1	1	2	1	2	1	1	3	4	2	1	3	5	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr13:49833572C>A	uc001vcu.2	+	4	419	c.343C>A	c.(343-345)CTT>ATT	p.L115I	CDADC1_uc001vcs.1_RNA|CDADC1_uc001vct.1_Intron|CDADC1_uc010tgk.1_Intron|CDADC1_uc001vcv.2_Intron	NM_030911	NP_112173	Q9BWV3	CDAC1_HUMAN	cytidine and dCMP deaminase domain containing 1	115							hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		Lung NSC(96;0.000705)|Breast(56;0.0011)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;1.06e-08)|COAD - Colon adenocarcinoma(199;0.216)		GCAGATTGCTCTTATTAAACA	0.368													47	107					6.21074e-16	7.12122e-16	1	0	A	49833572	A	A	49833572	3	1	51	1	0	0	0	0	1	0	0	0	3068	913	32	2	357	2	CDADC1	13	49833572	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	28091163	49833572	65336306	118	10240											
CTSG	1511	broad.mit.edu	37	chr14	25043576	25043576	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcacctctcggagtgtatCtgttcccctcctcatgctga	5	13	8	15	1	3	1	1	1	2	0	6	2	5	2	4	1	2	4	4	1	1	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr14:25043576C>T	uc001wpq.2	-	4	506	c.469G>A	c.(469-471)GAT>AAT	p.D157N		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	157	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		CGGAGTGTATCTGTTCCCCTC	0.637													20	139					0	0	0	0	T	25043576	T	T	25043576	3	4	51	1	0	0	0	0	1	0	0	0	4052	913	32	2	306	2	CTSG	14	25043576	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08		25043576	82305964	119	10241											
NPAS3	64067	broad.mit.edu	37	chr14	34145431	34145431	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctaggtggagctgacaggCagcagtgtctttgactatgt	8	12	13	8	0	2	2	0	2	2	0	2	3	2	3	0	3	2	3	0	3	2	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr14:34145431C>G	uc001wru.2	+	6	637	c.573C>G	c.(571-573)GGC>GGG	p.G191G	NPAS3_uc001wrs.2_Silent_p.G178G|NPAS3_uc001wrt.2_Silent_p.G159G|NPAS3_uc001wrv.2_Silent_p.G161G|NPAS3_uc001wrw.2_Silent_p.G89G	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	191	PAS 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		AGCTGACAGGCAGCAGTGTCT	0.537													35	167					0	0	0	0	G	34145431	G	G	34145431	2	3	51	1	0	0	0	0	0	0	0	1	10618	697	25	4		4	NPAS3	14	34145431	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	9101855	34145431	73204109	120	10242											
WDHD1	11169	broad.mit.edu	37	chr14	55457985	55457985	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctgactgaaatggcttttgCcggggagttggcatgggtcc	6	11	15	9	1	0	2	0	2	0	0	1	3	1	3	3	5	1	3	3	5	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr14:55457985C>T	uc001xbm.1	-	12	1365	c.1287G>A	c.(1285-1287)CGG>CGA	p.R429R	WDHD1_uc010aom.1_Missense_Mutation_p.G8D|WDHD1_uc001xbn.1_Silent_p.R306R	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	429						cytoplasm|nucleoplasm	DNA binding			skin(1)	1						ATGGCTTTTGCCGGGGAGTTG	0.448													4	108					0	0	0	0	T	55457985	T	T	55457985	2	4	51	1	0	0	0	0	0	0	0	1	17339	726	26	4		4	WDHD1	14	55457985	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	21312554	55457985	51891555	121	10243											
ARID4A	5926	broad.mit.edu	37	chr14	58831004	58831004	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttgaatgatgataagctaGatgaagaaaatccaaagatt	19	11	8	3	0	0	7	0	4	0	3	1	7	1	7	1	0	1	1	1	0	7	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr14:58831004G>C	uc001xdp.2	+	20	2451	c.2197G>C	c.(2197-2199)GAT>CAT	p.D733H	ARID4A_uc001xdo.2_Missense_Mutation_p.D733H|ARID4A_uc001xdq.2_Missense_Mutation_p.D733H|ARID4A_uc010apg.1_Missense_Mutation_p.D411H	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	733					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						TGATAAGCTAGATGAAGAAAA	0.289													15	140					0	0	0	0	C	58831004	C	C	58831004	3	2	51	1	0	0	0	0	1	0	0	0	919	942	33	2	2271	2	ARID4A	14	58831004	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	3373019	58831004	48518536	122	10244											
FLRT2	23768	broad.mit.edu	37	chr14	86089701	86089701	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatcgtctccttaaataacGatcaactccttaaaggagat	15	11	6	9	2	2	2	1	0	1	2	5	4	3	2	2	1	2	0	2	1	6	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr14:86089701G>A	uc001xvr.2	+	2	2610	c.1843G>A	c.(1843-1845)GAT>AAT	p.D615N	FLRT2_uc010atd.2_Missense_Mutation_p.D615N	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	615	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CTTAAATAACGATCAACTCCT	0.473													89	306					0	0	0	0	A	86089701	A	A	86089701	3	1	51	1	0	0	0	0	1	0	0	0	5971	1058	37	1	1845	1	FLRT2	14	86089701	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	27258697	86089701	21259839	123	10245											
RYR3	6263	broad.mit.edu	37	chr15	33936544	33936544	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgctgtctgggtctatctCagatcggccgcatgaatctc	6	13	10	12	2	5	2	1	1	5	1	8	2	5	2	1	2	1	2	1	2	2	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr15:33936544C>G	uc001zhi.2	+	28	3659	c.3589C>G	c.(3589-3591)CAG>GAG	p.Q1197E	RYR3_uc010bar.2_Missense_Mutation_p.Q1197E	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1197	B30.2/SPRY 2.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGGTCTATCTCAGATCGGCCG	0.527													9	32					0	0	0	0	G	33936544	G	G	33936544	3	3	51	1	0	0	0	0	1	0	0	0	13835	827	29	2	3699	2	RYR3	15	33936544	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08		33936544	68594848	124	10246											
MAPKBP1	23005	broad.mit.edu	37	chr15	42116702	42116702	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccagcggtgagcctggagCagtgtgagcagctggtggca	8	6	18	9	1	0	2	0	2	0	0	0	3	0	3	2	4	6	4	2	4	0	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr15:42116702C>T	uc001zok.3	+	31	4538	c.4252C>T	c.(4252-4254)CAG>TAG	p.Q1418*	MAPKBP1_uc001zoj.3_Nonsense_Mutation_p.Q1412*|MAPKBP1_uc010bcj.2_Nonsense_Mutation_p.Q919*|MAPKBP1_uc010bci.2_Nonsense_Mutation_p.Q1135*|MAPKBP1_uc010udb.1_Nonsense_Mutation_p.Q1251*|MAPKBP1_uc010bck.2_Nonsense_Mutation_p.Q629*|MAPKBP1_uc010bcl.2_Nonsense_Mutation_p.Q917*	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	1418										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GAGCCTGGAGCAGTGTGAGCA	0.652													5	22					0	0	0	0	T	42116702	T	T	42116702	4	4	51	1	0	0	0	0	0	1	0	0	9345	711	25	4	4370	4	MAPKBP1	15	42116702	Nonsense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	8180158	42116702	60414690	125	10247											
VPS39	23339	broad.mit.edu	37	chr15	42457994	42457994	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggcagagactccacttcCgggagatcttcagtaaatat	11	10	10	10	2	2	2	1	0	1	2	4	4	4	2	2	2	0	2	2	2	3	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr15:42457994C>T	uc001zpd.2	-	18	1885	c.1734G>A	c.(1732-1734)CCG>CCA	p.P578P	VPS39_uc001zpc.2_Silent_p.P567P|VPS39_uc001zpb.2_5'UTR	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	578					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		ACTCCACTTCCGGGAGATCTT	0.473													14	140					0	0	0	0	T	42457994	T	T	42457994	2	4	51	1	0	0	0	0	0	0	0	1	17277	639	23	1		1	VPS39	15	42457994	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	341292	42457994	60073398	126	10248											
ALPK3	57538	broad.mit.edu	37	chr15	85384080	85384080	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cacctcaggcctctgtgcagGtgccgacgccccctgcccgg	4	6	12	19	3	2	0	1	0	1	0	2	1	2	0	6	3	3	1	6	3	0	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr15:85384080G>T	uc002ble.2	+	5	2343	c.2176G>T	c.(2176-2178)GTG>TTG	p.V726L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	726					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCTGTGCAGGTGCCGACGCC	0.637													18	52					1.02788e-11	1.16034e-11	1	0	T	85384080	T	T	85384080	3	4	51	1	0	0	0	0	1	0	0	0	546	1261	44	4	2194	4	ALPK3	15	85384080	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	42926086	85384080	17147312	127	10249											
BLM	641	broad.mit.edu	37	chr15	91347415	91347415	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtagactttatggaaacaGaaaattccagcagtgtgaaa	17	9	10	5	0	0	3	0	1	0	2	1	4	1	4	1	2	2	2	1	2	6	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr15:91347415G>C	uc002bpr.2	+	19	3674	c.3577G>C	c.(3577-3579)GAA>CAA	p.E1193Q	BLM_uc010uqh.1_Missense_Mutation_p.E1193Q|BLM_uc010uqi.1_Missense_Mutation_p.E818Q|BLM_uc010bnx.2_Intron|BLM_uc002bpt.2_Missense_Mutation_p.E168Q	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	1193					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			TATGGAAACAGAAAATTCCAG	0.373			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				7	85					0	0	0	0	C	91347415	C	C	91347415	3	2	51	1	0	0	0	0	1	0	0	0	1448	943	33	2	3647	2	BLM	15	91347415	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	5963335	91347415	11183977	128	10250											
MAN2A2	4122	broad.mit.edu	37	chr15	91453879	91453879	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acgatgccatcactggcacgGccaaggaggctgtggtggtg	8	7	16	10	2	1	0	1	0	0	0	1	2	1	1	2	6	1	2	2	6	1	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr15:91453879G>A	uc010bnz.2	+	11	1841	c.1726G>A	c.(1726-1728)GCC>ACC	p.A576T	MAN2A2_uc010boa.2_Missense_Mutation_p.A618T|MAN2A2_uc002bqc.2_Missense_Mutation_p.A576T|MAN2A2_uc010uql.1_Missense_Mutation_p.A238T|MAN2A2_uc010uqm.1_Missense_Mutation_p.A155T|MAN2A2_uc010uqn.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	576	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CACTGGCACGGCCAAGGAGGC	0.587													4	131					0	0	0	0	A	91453879	A	A	91453879	3	1	51	1	0	0	0	0	1	0	0	0	9268	1203	42	4	1764	4	MAN2A2	15	91453879	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	106464	91453879	11077513	129	10251											
IGF1R	3480	broad.mit.edu	37	chr15	99500474	99500474	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccagagaacatggagagcGtccccctggacccctcggcc	9	4	12	16	2	0	2	0	0	0	2	2	5	1	3	6	3	3	0	6	3	1	0	rs45475702		TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr15:99500474G>A	uc002bul.2	+	21	3957	c.3907G>A	c.(3907-3909)GTC>ATC	p.V1303I	IGF1R_uc010bon.2_Missense_Mutation_p.V1302I	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	1303	Cytoplasmic (Potential).				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CATGGAGAGCGTCCCCCTGGA	0.667													11	54					0	0	0	0	A	99500474	A	A	99500474	3	1	51	1	0	0	0	0	1	0	0	0	7610	1145	40	1	3989	1	IGF1R	15	99500474	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	8046595	99500474	3030918	130	10252											
TMEM8A	58986	broad.mit.edu	37	chr16	426741	426741	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cggtgagacgcacggggcagCccaggctcccattggacacg	8	4	15	14	4	0	1	0	1	0	1	1	3	1	2	2	5	1	3	2	5	0	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr16:426741C>A	uc002cgu.3	-	5	836	c.707G>T	c.(706-708)GGC>GTC	p.G236V	TMEM8A_uc002cgv.3_Missense_Mutation_p.G43V	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	236	Extracellular (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3						CACGGGGCAGCCCAGGCTCCC	0.682													13	29					3.27435e-08	3.60343e-08	1	0	A	426741	A	A	426741	3	1	51	1	0	0	0	0	1	0	0	0	16280	739	26	4	1644	4	TMEM8A	16	426741	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08		426741	89928012	131	10253											
CREBBP	1387	broad.mit.edu	37	chr16	3820844	3820844	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccaggtggtgtcgtgtgctgGagagatggcatgccagcagc	7	8	17	9	1	0	1	0	0	0	1	1	3	0	2	2	4	4	3	2	4	0	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr16:3820844G>C	uc002cvv.2	-	14	2811	c.2607C>G	c.(2605-2607)CTC>CTG	p.L869L	CREBBP_uc002cvw.2_Silent_p.L831L	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	869					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TCGTGTGCTGGAGAGATGGCA	0.642			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				15	85					0	0	0	0	C	3820844	C	C	3820844	2	2	51	1	0	0	0	0	0	0	0	1	3876	1161	41	2		2	CREBBP	16	3820844	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	3394103	3820844	86533909	132	10254											
COG7	91949	broad.mit.edu	37	chr16	23428348	23428348	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccccaggccattggtgaatCtgacgcatctgtcaacggct	8	10	10	13	2	3	2	1	2	2	0	4	2	4	2	3	3	1	2	3	3	2	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr16:23428348C>G	uc002dlo.2	-	9	1420	c.1232G>C	c.(1231-1233)AGA>ACA	p.R411T		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	411					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		ATTGGTGAATCTGACGCATCT	0.582													7	109					0	0	0	0	G	23428348	G	G	23428348	3	3	51	1	0	0	0	0	1	0	0	0	3678	913	32	2	1116	2	COG7	16	23428348	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	19607504	23428348	66926405	133	10255											
KIFC3	3801	broad.mit.edu	37	chr16	57829031	57829031	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggagtcctcgtcaccgcaGactggggtatcttttccacg	6	11	11	13	3	2	1	1	0	1	1	5	2	4	2	3	3	0	2	3	3	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr16:57829031G>C	uc002emp.2	-	3	392	c.195C>G	c.(193-195)GTC>GTG	p.V65V	KIFC3_uc010cdf.2_5'UTR|KIFC3_uc002emo.3_5'UTR|KIFC3_uc010vhy.1_5'UTR|KIFC3_uc002emq.2_Silent_p.V65V|KIFC3_uc010vhz.1_Silent_p.V87V|KIFC3_uc002emr.1_Intron|KIFC3_uc010cdg.1_Intron	NM_005550	NP_005541	Q9BVG8	KIFC3_HUMAN	kinesin family member C3 isoform 1	65					epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			central_nervous_system(2)|ovary(1)	3		all_neural(199;0.224)				CGTCACCGCAGACTGGGGTAT	0.647													6	53					0	0	0	0	C	57829031	C	C	57829031	2	2	51	1	0	0	0	0	0	0	0	1	8353	929	33	2		2	KIFC3	16	57829031	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	34400683	57829031	32525722	134	10256											
HYDIN	54768	broad.mit.edu	37	chr16	70841774	70841774	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgagaagggaccttggggCttgggaggcagagccattcc	9	7	16	9	1	0	2	0	0	0	2	2	5	1	4	3	5	1	2	3	5	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr16:70841774C>T	uc002ezr.2	-	86	15200	c.15072G>A	c.(15070-15072)AAG>AAA	p.K5024K	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	5025										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GACCTTGGGGCTTGGGAGGCA	0.542													7	115					0	0	0	0	T	70841774	T	T	70841774	2	4	51	1	0	0	0	0	0	0	0	1	7506	796	28	4		4	HYDIN	16	70841774	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	13012743	70841774	19512979	135	10257											
MBTPS1	8720	broad.mit.edu	37	chr16	84093017	84093017	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcctccagaaccttggagtaCcgatgaagatggtttcctgt	9	11	11	10	1	0	3	0	1	0	2	2	5	2	4	5	2	2	2	5	2	3	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr16:84093017C>T	uc002fhi.2	-	21	3223	c.2721G>A	c.(2719-2721)CGG>CGA	p.R907R	MBTPS1_uc002fhh.2_Silent_p.R411R	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	907	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						CCTTGGAGTACCGATGAAGAT	0.468													3	52					0	0	0	0	T	84093017	T	T	84093017	2	4	51	1	0	0	0	0	0	0	0	1	9414	494	18	4		4	MBTPS1	16	84093017	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	13251243	84093017	6261736	136	10258											
TSR1	55720	broad.mit.edu	37	chr17	2237843	2237843	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtctccgggggcatctaTctgtttcatctggaaatcac	8	12	11	10	1	6	0	2	0	4	0	7	1	6	1	1	4	0	2	1	4	2	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:2237843T>C	uc002fuj.2	-	5	1861	c.904A>G	c.(904-906)ATA>GTA	p.I302V	SGSM2_uc002fum.3_5'Flank|SGSM2_uc010vqw.1_5'Flank|SGSM2_uc002fun.3_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	302					ribosome assembly	nucleolus	protein binding			ovary(1)	1						GGGGCATCTATCTGTTTCATC	0.443													84	290					0	0	0	0	C	2237843	C	C	2237843	3	2	51	1	0	0	0	0	1	0	0	0	16731	1435	50	5	1554	5	TSR1	17	2237843	Missense_Mutation	SNP	T	TCGA-CN-4740-01A-01D-1434-08		2237843	78957367	137	10259											
TP53	7157	broad.mit.edu	37	chr17	7578524	7578524	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggcaggtcttggccagttGgcaaaacatcttgttgaggg	9	10	15	7	0	2	1	0	1	2	0	2	1	2	1	1	5	1	4	1	5	2	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:7578524G>A	uc002gim.2	-	5	600	c.406C>T	c.(406-408)CAA>TAA	p.Q136*	TP53_uc002gig.1_Nonsense_Mutation_p.Q136*|TP53_uc002gih.2_Nonsense_Mutation_p.Q136*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q4*|TP53_uc010cng.1_Nonsense_Mutation_p.Q4*|TP53_uc002gii.1_Nonsense_Mutation_p.Q4*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q136*|TP53_uc010cni.1_Nonsense_Mutation_p.Q136*|TP53_uc002gij.2_Nonsense_Mutation_p.Q136*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.Q43*|TP53_uc002gio.2_Nonsense_Mutation_p.Q4*|TP53_uc010vug.1_Nonsense_Mutation_p.Q97*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	136	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q136*(28)|p.0?(7)|p.Q136H(5)|p.Q136Q(4)|p.Q136P(3)|p.Q136E(3)|p.N131fs*27(2)|p.Q136fs*13(2)|p.Q136R(2)|p.Q136fs*34(2)|p.V73fs*9(1)|p.F134_T140>S(1)|p.C135_T140delCQLAKT(1)|p.Q136K(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.Q136_K139delQLAK(1)|p.C135_Q136insX(1)|p.C135_Q136insXXXXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGCCAGTTGGCAAAACATC	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	58					0	0	0	0	A	7578524	A	A	7578524	4	1	51	1	0	0	0	0	0	1	0	0	16448	1357	47	4	892	4	TP53	17	7578524	Nonsense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	5340681	7578524	73616686	138	10260											
TP53	7157	broad.mit.edu	37	chr17	7579591	7579591	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgggacggcaagggggaCtgtagatgggtgaaaagagc	11	6	19	5	1	0	3	0	1	0	2	0	5	0	5	0	5	1	3	0	5	4	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:7579591C>T	uc002gim.2	-	4	291	c.97_splice	c.e4-1	p.S33_splice	TP53_uc002gig.1_Splice_Site_p.S33_splice|TP53_uc002gih.2_Splice_Site_p.S33_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Splice_Site_p.S33_splice|TP53_uc010cni.1_Splice_Site_p.S33_splice|TP53_uc002gij.2_Splice_Site_p.S33_splice|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Splice_Site|TP53_uc010cnk.1_Intron	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(5)|p.S33fs*10(1)|p.P13fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAAGGGGGACTGTAGATGGG	0.378		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	224					0	0	0	0	T	7579591	T	T	7579591	5	4	51	1	0	0	0	0	0	0	1	0	16448	579	20	4	1206	4	TP53	17	7579591	Splice_Site	SNP	C	TCGA-CN-4740-01A-01D-1434-08	1067	7579591	73615619	139	10261											
ZNF286A	57335	broad.mit.edu	37	chr17	15611559	15611559	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcccccaaaagcagctattCaggtgagccagatagatggg	13	6	12	10	0	1	3	1	1	0	2	1	3	1	3	3	2	4	2	3	2	4	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:15611559C>T	uc010cot.2	+	5	728	c.332C>T	c.(331-333)TCA>TTA	p.S111L	ZNF286A_uc002goz.3_5'UTR|ZNF286A_uc010vwa.1_Missense_Mutation_p.S111L|ZNF286A_uc002gpa.2_Missense_Mutation_p.S111L	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	111	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		AGCAGCTATTCAGGTGAGCCA	0.423													11	57					0	0	0	0	T	15611559	T	T	15611559	3	4	51	1	0	0	0	0	1	0	0	0	17890	838	29	2	346	2	ZNF286A	17	15611559	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	8031968	15611559	65583651	140	10262											
TP53I13	90313	broad.mit.edu	37	chr17	27896346	27896346	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatgtataggtgtcaccaaGagtgacctacacacgagtga	13	8	10	10	1	1	3	1	2	0	1	1	4	1	3	3	1	1	1	3	1	4	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:27896346G>A	uc002hee.2	+	3	190	c.152G>A	c.(151-153)AGA>AAA	p.R51K	ABHD15_uc002hed.1_5'Flank	NM_138349	NP_612358	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	51	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane					0				READ - Rectum adenocarcinoma(3;0.236)		GTGTCACCAAGAGTGACCTAC	0.632													4	38					0	0	0	0	A	27896346	A	A	27896346	3	1	51	1	0	0	0	0	1	0	0	0	16453	942	33	2	162	2	TP53I13	17	27896346	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	12284787	27896346	53298864	141	10263											
SSH2	85464	broad.mit.edu	37	chr17	27958830	27958830	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggctgctgcctctgtcttCagggctactcaggatggagg	6	10	14	11	0	4	0	2	0	2	0	4	2	4	2	1	5	3	3	1	5	1	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:27958830C>G	uc002heo.1	-	15	3301	c.3301G>C	c.(3301-3303)GAA>CAA	p.E1101Q	SSH2_uc010wbh.1_Missense_Mutation_p.E1128Q	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	1101					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						CCTCTGTCTTCAGGGCTACTC	0.547													12	116					0	0	0	0	G	27958830	G	G	27958830	3	3	51	1	0	0	0	0	1	0	0	0	15251	835	29	2	974	2	SSH2	17	27958830	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	62484	27958830	53236380	142	10264											
SLFN13	146857	broad.mit.edu	37	chr17	33770858	33770858	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgttccagacctttcttaGaatacactggtctgcaaagt	10	14	8	9	0	2	2	0	0	2	2	3	2	3	2	2	1	2	2	2	1	4	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:33770858G>A	uc002hjk.1	-	2	1478	c.1148C>T	c.(1147-1149)TCT>TTT	p.S383F	SLFN13_uc010wch.1_Missense_Mutation_p.S383F|SLFN13_uc002hjl.2_Missense_Mutation_p.S383F|SLFN13_uc010ctt.2_Missense_Mutation_p.S65F|SLFN13_uc002hjm.2_Missense_Mutation_p.S52F	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	383						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ACCTTTCTTAGAATACACTGG	0.398													10	96					0	0	0	0	A	33770858	A	A	33770858	3	1	51	1	0	0	0	0	1	0	0	0	14800	942	33	2	1557	2	SLFN13	17	33770858	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	5812028	33770858	47424352	143	10265											
MED1	5469	broad.mit.edu	37	chr17	37563769	37563769	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atccataagatcatcatcttCctccccaatcataaagtctg	13	12	3	13	0	5	1	3	0	2	1	8	1	8	1	4	0	0	0	4	0	4	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:37563769C>T	uc002hrv.3	-	17	4917	c.4705G>A	c.(4705-4707)GAA>AAA	p.E1569K	MED1_uc010wee.1_Missense_Mutation_p.E1397K|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1569					androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TCATCATCTTCCTCCCCAATC	0.413										HNSCC(31;0.082)			28	96					0	0	0	0	T	37563769	T	T	37563769	3	4	51	1	0	0	0	0	1	0	0	0	9478	864	30	2	44	2	MED1	17	37563769	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	3792911	37563769	43631441	144	10266											
C17orf71	55181	broad.mit.edu	37	chr17	57290700	57290700	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatgggaagaggaagacggcGagatgacatagctcgagctt	14	6	15	6	3	0	4	0	1	0	3	1	8	0	6	0	3	2	2	0	3	4	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:57290700G>A	uc002ixi.2	+	3	2558	c.2516G>A	c.(2515-2517)CGA>CAA	p.R839Q		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	839					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					GGAAGACGGCGAGATGACATA	0.463													26	208					0	0	0	0	A	57290700	A	A	57290700	3	1	51	1	0	0	0	0	1	0	0	0	1885	1058	37	1	2526	1	C17orf71	17	57290700	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	19726931	57290700	23904510	145	10267											
ABCA10	10349	broad.mit.edu	37	chr17	67149444	67149444	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acttaatattcactctccttAccacatttgctgctgcccct	8	15	3	15	0	2	0	1	0	1	0	3	0	2	0	4	0	4	2	4	0	3	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:67149444A>T	uc010dfa.1	-	35	5015	c.4136_splice	c.e35+1	p.W1379_splice	ABCA10_uc002jhz.2_5'Flank|ABCA10_uc010wqs.1_Splice_Site_p.W371_splice|ABCA10_uc010wqt.1_Splice_Site	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10						transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CACTCTCCTTACCACATTTGC	0.438													15	161					0	0	0	0	T	67149444	T	T	67149444	5	4	51	1	0	0	0	0	0	0	1	0	29	405	14	5	517	5	ABCA10	17	67149444	Splice_Site	SNP	A	TCGA-CN-4740-01A-01D-1434-08	9858744	67149444	14045766	146	10268											
SSTR2	6752	broad.mit.edu	37	chr17	71166496	71166496	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagtgacagtaagcaggaCaaatcccggctgaatgagac	14	5	13	9	2	0	3	0	3	0	1	1	6	1	5	1	3	1	3	1	3	3	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:71166496C>A	uc002jje.2	+	2	1398	c.1038C>A	c.(1036-1038)GAC>GAA	p.D346E		NM_001050	NP_001041	P30874	SSR2_HUMAN	somatostatin receptor 2	346	Cytoplasmic (Potential).				digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity				0			LUSC - Lung squamous cell carcinoma(166;0.197)			GTAAGCAGGACAAATCCCGGC	0.537													37	99					6.84511e-11	7.68759e-11	1	0	A	71166496	A	A	71166496	3	1	51	1	0	0	0	0	1	0	0	0	15264	477	17	4	1040	4	SSTR2	17	71166496	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	4017052	71166496	10028714	147	10269											
GRIN2C	2905	broad.mit.edu	37	chr17	72858493	72858494	+	5'Flank	INS	-	C	C																															ggctgccgagccccatcaagINSccccaatgaggcccctgagc																								rs150874217	by1000genomes	TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:72858493_72858494insC	uc002jlt.1	-						GRIN2C_uc010wrh.1_5'Flank|GRIN2C_uc002jlu.1_5'Flank|GRIN2C_uc002jlv.1_5'Flank	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C						glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GCCCCATCAAGCCCCAATGAGG	0.658											OREG0024719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								C	72858494	C	C	72858493	6	5	51	0	1	1	1	0	0	0	0	0	6820	986	34	0		0	GRIN2C	17	72858493	5'Flank	INS	-	TCGA-CN-4740-01A-01D-1434-08	1691997	72858493	8336717	148	10270											
BAIAP2	10458	broad.mit.edu	37	chr17	79058642	79058642	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttcccaggagacgttctCttccagatggctgaagtcca	8	11	10	12	1	1	3	0	1	1	2	5	4	4	3	3	2	1	3	3	2	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr17:79058642C>T	uc002jzg.2	+	4	336	c.228C>T	c.(226-228)CTC>CTT	p.L76L	BAIAP2_uc002jyz.3_Silent_p.L76L|BAIAP2_uc002jza.2_Silent_p.L76L|BAIAP2_uc002jzc.2_Silent_p.L76L|BAIAP2_uc002jzb.2_5'UTR|BAIAP2_uc002jzd.2_Silent_p.L76L|BAIAP2_uc002jzf.2_Silent_p.L76L|BAIAP2_uc002jze.2_Silent_p.L109L|BAIAP2_uc010wuh.1_5'UTR|BAIAP2_uc002jzh.2_5'Flank	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	76	IMD.				axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GAGACGTTCTCTTCCAGATGG	0.622													35	298					0	0	0	0	T	79058642	T	T	79058642	2	4	51	1	0	0	0	0	0	0	0	1	1303	900	32	2		2	BAIAP2	17	79058642	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	6200149	79058642	2136568	149	10271											
SMCHD1	23347	broad.mit.edu	37	chr18	2732357	2732357	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attcagtgtagaaggacaaaAggcaattcagatcaaacatc	18	8	8	7	0	3	2	3	0	0	2	4	3	3	3	0	2	1	2	0	2	6	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr18:2732357A>T	uc002klm.3	+	25	3332	c.3143A>T	c.(3142-3144)AAG>ATG	p.K1048M	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1048					chromosome organization		ATP binding				0						GAAGGACAAAAGGCAATTCAG	0.368													18	121					0	0	0	0	T	2732357	T	T	2732357	3	4	51	1	0	0	0	0	1	0	0	0	14852	72	3	5	3241	5	SMCHD1	18	2732357	Missense_Mutation	SNP	A	TCGA-CN-4740-01A-01D-1434-08		2732357	75344891	150	10272											
FECH	2235	broad.mit.edu	37	chr18	55218580	55218580	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatttccattaagagactcAgctcttctgatgttttcaac	10	15	7	9	0	4	2	2	1	2	1	5	4	5	3	1	1	2	2	1	1	2	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr18:55218580A>G	uc002lgq.3	-	10	1221	c.1104T>C	c.(1102-1104)GCT>GCC	p.A368A	FECH_uc002lgp.3_Silent_p.A374A|FECH_uc002lgr.3_Silent_p.A226A	NM_000140	NP_000131	P22830	HEMH_HUMAN	ferrochelatase isoform b precursor	368					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)	1		Colorectal(73;0.227)				TAAGAGACTCAGCTCTTCTGA	0.343													6	75					0	0	0	0	G	55218580	G	G	55218580	2	3	51	1	0	0	0	0	0	0	0	1	5840	175	7	5		5	FECH	18	55218580	Silent	SNP	A	TCGA-CN-4740-01A-01D-1434-08	52486223	55218580	22858668	151	10273											
ALPK2	115701	broad.mit.edu	37	chr18	56203584	56203584	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaacagcatctgcctttaGactatcaggtacagcccaga	13	8	7	13	0	2	2	1	0	1	2	2	2	2	2	2	1	5	2	2	1	4	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr18:56203584G>A	uc002lhj.3	-	5	4049	c.3835C>T	c.(3835-3837)CTA>TTA	p.L1279L	ALPK2_uc002lhk.1_Silent_p.L610L	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1279							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TCTGCCTTTAGACTATCAGGT	0.502													29	237					0	0	0	0	A	56203584	A	A	56203584	2	1	51	1	0	0	0	0	0	0	0	1	545	933	33	2		2	ALPK2	18	56203584	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	985004	56203584	21873664	152	10274											
ALPK2	115701	broad.mit.edu	37	chr18	56203904	56203904	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttgcgggtgagtgggccGtgggcaccaagtttctttcc	5	11	15	10	2	1	1	0	1	1	0	2	1	2	1	3	3	2	3	3	3	1	3	rs140868694	byFrequency	TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr18:56203904G>A	uc002lhj.3	-	5	3729	c.3515C>T	c.(3514-3516)ACG>ATG	p.T1172M	ALPK2_uc002lhk.1_Missense_Mutation_p.T503M	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1172							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TGAGTGGGCCGTGGGCACCAA	0.577													6	131					0	0	0	0	A	56203904	A	A	56203904	3	1	51	1	0	0	0	0	1	0	0	0	545	1145	40	1	3033	1	ALPK2	18	56203904	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	320	56203904	21873344	153	10275											
CD209	30835	broad.mit.edu	37	chr19	7809920	7809920	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccgctgggagttagacatGaagtaacagtttccttggaa	11	12	11	7	1	0	2	0	1	0	1	2	4	2	4	2	2	1	4	2	2	4	5			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr19:7809920G>A	uc002mht.2	-	5	874	c.807C>T	c.(805-807)TTC>TTT	p.F269F	CD209_uc010xju.1_Silent_p.F108F|CD209_uc010dvp.2_Silent_p.F245F|CD209_uc002mhr.2_Silent_p.F245F|CD209_uc002mhs.2_Silent_p.F199F|CD209_uc002mhu.2_Silent_p.F177F|CD209_uc010dvq.2_Silent_p.F269F|CD209_uc002mhq.2_Silent_p.F269F|CD209_uc002mhv.2_Silent_p.F245F|CD209_uc002mhx.2_Silent_p.F225F|CD209_uc002mhw.2_Silent_p.F133F|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	269	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						AGTTAGACATGAAGTAACAGT	0.562													20	124					0	0	0	0	A	7809920	A	A	7809920	2	1	51	1	0	0	0	0	0	0	0	1	2999	1281	45	2		2	CD209	19	7809920	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08		7809920	51319063	154	10276											
KRI1	65095	broad.mit.edu	37	chr19	10664771	10664771	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atcacagtggggcccagcagCcgtgccttcttggccctcct	5	9	11	16	1	2	0	1	0	1	0	3	0	3	0	5	3	3	1	5	3	0	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr19:10664771C>T	uc002moy.1	-	19	1995	c.1986G>A	c.(1984-1986)CGG>CGA	p.R662R	KRI1_uc002mow.1_Silent_p.R281R|KRI1_uc002mox.1_Silent_p.R658R	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	662										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GGCCCAGCAGCCGTGCCTTCT	0.647													16	187					0	0	0	0	T	10664771	T	T	10664771	2	4	51	1	0	0	0	0	0	0	0	1	8483	726	26	4		4	KRI1	19	10664771	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	2854851	10664771	48464212	155	10277											
KRI1	65095	broad.mit.edu	37	chr19	10665764	10665764	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagccagcactgcttactCttctcggcagagtgacttga	8	10	9	14	1	2	3	0	2	2	1	3	3	2	3	2	1	4	3	2	1	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr19:10665764C>G	uc002moy.1	-	18	1807	c.1798G>C	c.(1798-1800)GAG>CAG	p.E600Q	KRI1_uc002mow.1_Missense_Mutation_p.E219Q|KRI1_uc002mox.1_Missense_Mutation_p.E596Q	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	600										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			actgcttactcttctCGGCAG	0.299													7	83					0	0	0	0	G	10665764	G	G	10665764	3	3	51	1	0	0	0	0	1	0	0	0	8483	927	32	2	339	2	KRI1	19	10665764	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	993	10665764	48463219	156	10278											
TNPO2	30000	broad.mit.edu	37	chr19	12817445	12817445	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtttgagcagctctgtcaTcaggggcttgaggtgcatgt	6	12	15	8	1	3	2	2	2	1	0	3	2	3	2	0	3	3	5	0	3	0	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr19:12817445T>A	uc002muo.2	-	13	1620	c.1435A>T	c.(1435-1437)ATG>TTG	p.M479L	TNPO2_uc002mup.2_Missense_Mutation_p.M571L|TNPO2_uc002muq.2_Missense_Mutation_p.M479L|TNPO2_uc002mur.2_Missense_Mutation_p.M479L|SNORD41_uc002mut.1_5'Flank	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	479	HEAT 8.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						AGCTCTGTCATCAGGGGCTTG	0.637													14	54					0	0	0	0	A	12817445	A	A	12817445	3	1	51	1	0	0	0	0	1	0	0	0	16402	1435	50	5	1306	5	TNPO2	19	12817445	Missense_Mutation	SNP	T	TCGA-CN-4740-01A-01D-1434-08	2151681	12817445	46311538	157	10279											
WDR62	284403	broad.mit.edu	37	chr19	36562559	36562559	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccatagcctgcactacctCgccaacctgcccaagccaca	10	5	6	20	1	0	0	0	0	0	0	1	0	0	0	7	0	6	1	7	0	4	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr19:36562559C>T	uc002odc.2	+	8	1075	c.984C>T	c.(982-984)CTC>CTT	p.L328L	WDR62_uc002odd.2_Silent_p.L328L|WDR62_uc002odb.2_Silent_p.L328L	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	328	WD 4.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TGCACTACCTCGCCAACCTGC	0.622													10	93					0	0	0	0	T	36562559	T	T	36562559	2	4	51	1	0	0	0	0	0	0	0	1	17381	871	31	1		1	WDR62	19	36562559	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	23745114	36562559	22566424	158	10280											
ATP1A3	478	broad.mit.edu	37	chr19	42471887	42471887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcagccagggccgtctcctCaaacagcccgaagatcagga	11	4	12	14	2	3	1	2	0	1	1	4	3	3	2	4	3	3	1	4	3	2	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr19:42471887C>T	uc002osg.2	-	21	3002	c.2848G>A	c.(2848-2850)GAG>AAG	p.E950K	ATP1A3_uc010xwf.1_Missense_Mutation_p.E961K|ATP1A3_uc010xwg.1_Missense_Mutation_p.E920K|ATP1A3_uc010xwh.1_Missense_Mutation_p.E963K|ATP1A3_uc002osh.2_Missense_Mutation_p.E950K	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	950	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						GCCGTCTCCTCAAACAGCCCG	0.667													6	47					0	0	0	0	T	42471887	T	T	42471887	3	4	51	1	0	0	0	0	1	0	0	0	1132	835	29	2	205	2	ATP1A3	19	42471887	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	5909328	42471887	16657096	159	10281											
ZNF347	84671	broad.mit.edu	37	chr19	53644064	53644064	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttacctccagtatgaactcTccgatgtcttgcaaggtgtg	8	14	9	10	1	2	1	0	1	2	0	4	2	3	1	3	1	3	2	3	1	4	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr19:53644064T>C	uc002qbb.1	-	5	2086	c.2017A>G	c.(2017-2019)AGA>GGA	p.R673G	ZNF347_uc010eql.1_Missense_Mutation_p.R674G|ZNF347_uc002qbc.1_Missense_Mutation_p.R674G	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	673	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		GTATGAACTCTCCGATGTCTT	0.428													4	285					0	0	0	0	C	53644064	C	C	53644064	3	2	51	1	0	0	0	0	1	0	0	0	17928	1559	54	5	506	5	ZNF347	19	53644064	Missense_Mutation	SNP	T	TCGA-CN-4740-01A-01D-1434-08	11172177	53644064	5484919	160	10282											
RPS5	6193	broad.mit.edu	37	chr19	58899511	58899511	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caccctgtcccaggatgaccGagtgggagacagcagcacca	11	4	12	14	1	0	2	0	1	0	1	1	5	1	3	4	2	2	2	4	2	0	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr19:58899511G>C	uc002qsn.2	+	2	79	c.7G>C	c.(7-9)GAG>CAG	p.E3Q	RPS5_uc002qso.2_Missense_Mutation_p.E3Q	NM_001009	NP_001000	P46782	RS5_HUMAN	ribosomal protein S5	3					endocrine pancreas development|regulation of translational fidelity|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|structural constituent of ribosome				0		all_cancers(17;1.71e-22)|all_epithelial(17;1.69e-16)|Lung NSC(17;2.25e-06)|all_lung(17;9.97e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Breast(46;0.0194)|Ovarian(87;0.0443)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.171)|GBM - Glioblastoma multiforme(193;0.0323)|Lung(386;0.0543)|LUSC - Lung squamous cell carcinoma(496;0.176)		CAGGATGACCGAGTGGGAGAC	0.552													5	35					0	0	0	0	C	58899511	C	C	58899511	3	2	51	1	0	0	0	0	1	0	0	0	13713	1059	37	3	9	3	RPS5	19	58899511	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	5255447	58899511	229472	161	10283											
ZBTB45	84878	broad.mit.edu	37	chr19	59028386	59028386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accttcgccatcctcgccatCggtctcatcgtcactttcct	5	13	5	18	4	2	0	2	0	1	0	9	0	4	0	5	1	0	0	5	1	0	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr19:59028386C>T	uc002qtd.2	-	2	947	c.655G>A	c.(655-657)GAT>AAT	p.D219N	ZBTB45_uc002qte.2_Missense_Mutation_p.D219N|ZBTB45_uc002qtf.2_Missense_Mutation_p.D219N	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	219					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		TCCTCGCCATCGGTCTCATCG	0.647											OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	61	529					0	0	0	0	T	59028386	T	T	59028386	3	4	51	1	0	0	0	0	1	0	0	0	17613	884	31	1	888	1	ZBTB45	19	59028386	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	128875	59028386	100597	162	10284											
SIGLEC1	6614	broad.mit.edu	37	chr20	3673302	3673302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggaccctcctgcagccaaCgaccgttgtggtaccaagta	9	8	10	14	2	0	0	0	0	0	0	1	2	1	1	5	2	4	4	5	2	4	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr20:3673302C>T	uc002wja.2	-	15	3896	c.3896G>A	c.(3895-3897)CGT>CAT	p.R1299H	SIGLEC1_uc002wjb.1_5'UTR|SIGLEC1_uc002wiz.3_Missense_Mutation_p.R1299H	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1299	Ig-like C2-type 13.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CTGCAGCCAACGACCGTTGTG	0.657													12	55					0	0	0	0	T	3673302	T	T	3673302	3	4	51	1	0	0	0	0	1	0	0	0	14370	536	19	1	1261	1	SIGLEC1	20	3673302	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08		3673302	59352218	163	10285											
JAG1	182	broad.mit.edu	37	chr20	10625009	10625009	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggatgtcacacttaccaggGatgagggctgcagtcattgg	10	9	14	8	0	2	1	2	1	0	0	2	3	2	3	1	4	2	2	1	4	1	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr20:10625009G>A	uc002wnw.2	-	19	2884	c.2368C>T	c.(2368-2370)CCC>TCC	p.P790S	JAG1_uc010gcd.1_Missense_Mutation_p.P348S	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	790	EGF-like 15; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						ACTTACCAGGGATGAGGGCTG	0.323									Alagille_Syndrome				4	41					0	0	0	0	A	10625009	A	A	10625009	3	1	51	1	0	0	0	0	1	0	0	0	7973	1174	41	2	1320	2	JAG1	20	10625009	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	6951707	10625009	52400511	164	10286											
C20orf79	140856	broad.mit.edu	37	chr20	18794470	18794470	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcacaggaagatgtggaagaGaagtgaccatcaacccaaga	17	4	12	8	0	1	4	1	1	0	3	1	7	1	6	2	2	1	1	2	2	5	0			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr20:18794470G>C	uc002wrk.2	+	1	101	c.11G>C	c.(10-12)AGA>ACA	p.R4T	uc002wrj.1_Intron	NM_178483	NP_848578	Q9UJQ7	CT079_HUMAN	hypothetical protein LOC140856	4							sterol binding			skin(3)	3						ATGTGGAAGAGAAGTGACCAT	0.512													12	98					0	0	0	0	C	18794470	C	C	18794470	3	2	51	1	0	0	0	0	1	0	0	0	2129	942	33	2	13	2	C20orf79	20	18794470	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	8169461	18794470	44231050	165	10287											
SUN5	140732	broad.mit.edu	37	chr20	31572920	31572920	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtacctggagtgggaacatCtggatgatgttttctggctg	7	13	15	6	0	2	1	0	1	2	0	2	4	2	4	1	5	2	3	1	5	2	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr20:31572920C>T	uc002wyi.2	-	12	1062	c.969G>A	c.(967-969)CAG>CAA	p.Q323Q		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	323	SUN.				spermatogenesis					skin(1)	1						GTGGGAACATCTGGATGATGT	0.353													17	153					0	0	0	0	T	31572920	T	T	31572920	2	4	51	1	0	0	0	0	0	0	0	1	15460	912	32	2		2	SUN5	20	31572920	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	12778450	31572920	31452600	166	10288											
RBL1	5933	broad.mit.edu	37	chr20	35696492	35696492	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatattacagtagacacctCaaaatttctctctagccttt	13	14	4	10	0	3	1	1	0	2	1	4	2	3	1	2	0	2	1	2	0	7	6			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr20:35696492C>T	uc002xgi.2	-	3	467	c.388G>A	c.(388-390)GAG>AAG	p.E130K	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.E130K|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	130					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				GTAGACACCTCAAAATTTCTC	0.313													8	69					0	0	0	0	T	35696492	T	T	35696492	3	4	51	1	0	0	0	0	1	0	0	0	13174	835	29	2	2907	2	RBL1	20	35696492	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	4123572	35696492	27329028	167	10289											
PTPRT	11122	broad.mit.edu	37	chr20	41408885	41408885	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgagcaaggacccggacctCgtccacggcgatgtagccag	10	5	13	13	4	0	1	0	1	0	0	2	4	1	3	4	3	2	2	4	3	2	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr20:41408885C>T	uc002xkg.2	-	4	725	c.541G>A	c.(541-543)GAG>AAG	p.E181K	PTPRT_uc010ggj.2_Missense_Mutation_p.E181K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	181	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ACCCGGACCTCGTCCACGGCG	0.527													12	156					0	0	0	0	T	41408885	T	T	41408885	3	4	51	1	0	0	0	0	1	0	0	0	12877	893	31	1	3957	1	PTPRT	20	41408885	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	5712393	41408885	21616635	168	10290											
LIPI	149998	broad.mit.edu	37	chr21	15537706	15537706	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggttgcatttaatgaattGaattccttaagggttaaaaa	14	15	9	3	0	0	2	0	2	0	0	1	2	1	2	1	2	1	3	1	2	7	7			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr21:15537706G>C	uc002yjm.2	-	6	812	c.802C>G	c.(802-804)CAA>GAA	p.Q268E	LIPI_uc010gkw.1_Missense_Mutation_p.Q171E	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	247					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTAATGAATTGAATTCCTTAA	0.303													8	105					0	0	0	0	C	15537706	C	C	15537706	3	2	51	1	0	0	0	0	1	0	0	0	8867	1299	45	2	663	2	LIPI	21	15537706	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08		15537706	32592189	169	10291											
CECR2	27443	broad.mit.edu	37	chr22	18020172	18020172	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaacattttcctggagaaGatggagacacagatgaagaa	17	8	11	5	0	0	7	0	2	0	5	1	9	1	7	1	2	1	0	1	2	4	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr22:18020172G>C	uc010gqw.1	+	13	1627	c.1501G>C	c.(1501-1503)GAT>CAT	p.D501H	CECR2_uc010gqv.1_Missense_Mutation_p.D360H|CECR2_uc002zml.2_Missense_Mutation_p.D360H	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	543					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		TCCTGGAGAAGATGGAGACAC	0.463													7	14					0	0	0	0	C	18020172	C	C	18020172	3	2	51	1	0	0	0	0	1	0	0	0	3221	942	33	2	1553	2	CECR2	22	18020172	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08		18020172	33284394	170	10292											
C22orf25	128989	broad.mit.edu	37	chr22	20049075	20049075	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acctacgggctgagcaacgcGctgctggagactccctggag	8	6	14	13	3	0	2	0	1	0	1	1	4	1	3	2	3	4	4	2	3	2	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr22:20049075G>A	uc010grw.1	+	8	811	c.474G>A	c.(472-474)GCG>GCA	p.A158A	C22orf25_uc002zrb.1_Silent_p.A96A|C22orf25_uc002zrc.1_Silent_p.A158A|C22orf25_uc002zrd.1_Silent_p.A124A|C22orf25_uc011ahe.1_Intron|C22orf25_uc011ahf.1_Intron|C22orf25_uc011ahg.1_Intron|C22orf25_uc002zrg.2_Silent_p.A199A|C22orf25_uc011ahh.1_Silent_p.A158A|C22orf25_uc002zrf.2_Silent_p.A96A|C22orf25_uc011ahi.1_Silent_p.A60A|C22orf25_uc010gry.1_Intron|C22orf25_uc002zrh.1_Silent_p.A60A	NM_152906	NP_690870	Q6ICL3	CV025_HUMAN	hypothetical protein LOC128989	158											0	Colorectal(54;0.0533)					TGAGCAACGCGCTGCTGGAGA	0.627													3	17					0	0	0	0	A	20049075	A	A	20049075	2	1	51	1	0	0	0	0	0	0	0	1	2149	1074	38	1		1	C22orf25	22	20049075	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	2028903	20049075	31255491	171	10293											
LZTR1	8216	broad.mit.edu	37	chr22	21347982	21347982	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctaaatgcacgctgcacgAggactacgggcggctgtggg	8	6	15	12	4	0	0	0	0	0	0	0	2	0	1	1	4	3	4	1	4	3	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr22:21347982A>T	uc002zto.2	+	12	1395	c.1292A>T	c.(1291-1293)GAG>GTG	p.E431V	LZTR1_uc002ztn.2_Missense_Mutation_p.E390V|LZTR1_uc011ahy.1_Missense_Mutation_p.E412V|LZTR1_uc010gsr.1_Missense_Mutation_p.E302V|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	431	Kelch 6.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			ACGCTGCACGAGGACTACGGG	0.637													11	43					0	0	0	0	T	21347982	T	T	21347982	3	4	51	1	0	0	0	0	1	0	0	0	9188	304	11	5	1338	5	LZTR1	22	21347982	Missense_Mutation	SNP	A	TCGA-CN-4740-01A-01D-1434-08	1298907	21347982	29956584	172	10294											
GAL3ST1	9514	broad.mit.edu	37	chr22	30953272	30953272	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggccaggccggcatgcagCgggggcacggcataggagta	9	3	19	10	3	0	0	0	0	0	0	0	2	0	1	2	7	2	5	2	7	2	2			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr22:30953272C>T	uc003aig.1	-	3	248	c.108G>A	c.(106-108)CCG>CCA	p.P36P	GAL3ST1_uc003aih.1_Silent_p.P36P|GAL3ST1_uc003aii.1_Silent_p.P36P|GAL3ST1_uc010gvz.1_Silent_p.P36P	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	36	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CGGCATGCAGCGGGGGCACGG	0.647													9	116					0	0	0	0	T	30953272	T	T	30953272	2	4	51	1	0	0	0	0	0	0	0	1	6232	755	27	1		1	GAL3ST1	22	30953272	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	9605290	30953272	20351294	173	10295											
NAGA	4668	broad.mit.edu	37	chr22	42456988	42456988	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggagtggtagcgataaggCatatcggtcctgcagctgaa	11	8	15	7	2	0	1	0	1	0	0	2	4	1	2	1	4	3	4	1	4	4	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr22:42456988C>T	uc003bbx.2	-	9	1178	c.1041G>A	c.(1039-1041)ATG>ATA	p.M347I	NAGA_uc003bby.2_Missense_Mutation_p.M347I|NAGA_uc003bbw.3_Missense_Mutation_p.M347I	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	347					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						AGCGATAAGGCATATCGGTCC	0.567													15	116					0	0	0	0	T	42456988	T	T	42456988	3	4	51	1	0	0	0	0	1	0	0	0	10194	710	25	4	202	4	NAGA	22	42456988	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	11503716	42456988	8847578	174	10296											
SBF1	6305	broad.mit.edu	37	chr22	50898432	50898432	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaaatgcggaagggctcaGacttggcccggctcaggctg	9	6	16	10	2	2	2	2	0	0	2	2	4	2	3	1	5	1	3	1	5	2	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chr22:50898432G>C	uc003blh.2	-	26	3635	c.3440C>G	c.(3439-3441)TCT>TGT	p.S1147C	SBF1_uc011arx.1_Missense_Mutation_p.S811C	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1147	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GAAGGGCTCAGACTTGGCCCG	0.662													15	105					0	0	0	0	C	50898432	C	C	50898432	3	2	51	1	0	0	0	0	1	0	0	0	13923	942	33	2	2305	2	SBF1	22	50898432	Missense_Mutation	SNP	G	TCGA-CN-4740-01A-01D-1434-08	8441444	50898432	406134	175	10297											
RPS6KA3	6197	broad.mit.edu	37	chrX	20190890	20190890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcaaactccatgtttgtagCtttatgtatacatctcttgc	9	17	6	9	0	1	0	0	0	1	0	3	0	2	0	1	0	5	5	1	0	5	7			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chrX:20190890C>T	uc004czu.2	-	15	1327	c.1327G>A	c.(1327-1329)GCT>ACT	p.A443T	RPS6KA3_uc011mjk.1_Missense_Mutation_p.A413T|RPS6KA3_uc004czv.2_Missense_Mutation_p.A430T|RPS6KA3_uc011mjl.1_Missense_Mutation_p.A414T|RPS6KA3_uc011mjm.1_Missense_Mutation_p.A415T	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	443	Protein kinase 2.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						ATGTTTGTAGCTTTATGTATA	0.333													11	33					0	0	0	0	T	20190890	T	T	20190890	3	4	51	1	0	0	0	0	1	0	0	0	13717	797	28	4	927	4	RPS6KA3	23	20190890	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08		20190890	135079670	176	10298											
CXorf21	80231	broad.mit.edu	37	chrX	30578442	30578442	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggatgtcattccagtactCaagtccactgagataccctt	10	12	8	11	0	2	1	2	1	0	1	4	3	4	2	3	1	2	1	3	1	3	4			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chrX:30578442C>G	uc004dcg.1	-	3	307	c.31G>C	c.(31-33)GAG>CAG	p.E11Q		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	11										ovary(1)	1						TTCCAGTACTCAAGTCCACTG	0.418													13	95					0	0	0	0	G	30578442	G	G	30578442	3	3	51	1	0	0	0	0	1	0	0	0	4118	835	29	2	878	2	CXorf21	23	30578442	Missense_Mutation	SNP	C	TCGA-CN-4740-01A-01D-1434-08	10387552	30578442	124692118	177	10299											
RPGR	6103	broad.mit.edu	37	chrX	38156556	38156556	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggttcctctggctgcatGaggtcctgttcagataagac	7	12	11	11	0	2	3	1	1	1	2	4	3	4	3	3	3	1	4	3	3	1	3			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chrX:38156556G>T	uc004ded.1	-	11	1563	c.1395C>A	c.(1393-1395)CTC>CTA	p.L465L	RPGR_uc004deb.2_Silent_p.L465L|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA|RPGR_uc004dee.1_Silent_p.L150L	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	465					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						CTGGCTGCATGAGGTCCTGTT	0.418													9	103					3.86212e-05	4.10585e-05	1	0	T	38156556	T	T	38156556	2	4	51	1	0	0	0	0	0	0	0	1	13613	1277	45	2		2	RPGR	23	38156556	Silent	SNP	G	TCGA-CN-4740-01A-01D-1434-08	7578114	38156556	117114004	178	10300											
TEX13A	56157	broad.mit.edu	37	chrX	104464803	104464803	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcagtttggcgaagccgtgCagccaccgcaccctgtgcct	6	8	12	15	3	0	0	0	0	0	0	0	1	0	0	5	1	5	4	5	1	1	1			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chrX:104464803C>A	uc004ema.2	-	2	391	c.279G>T	c.(277-279)CTG>CTT	p.L93L	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Silent_p.L93L	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	93						intracellular	zinc ion binding			ovary(2)	2						CGAAGCCGTGCAGCCACCGCA	0.632													9	41					0.000274275	0.000287398	1	0	A	104464803	A	A	104464803	2	1	51	1	0	0	0	0	0	0	0	1	15842	697	25	4		4	TEX13A	23	104464803	Silent	SNP	C	TCGA-CN-4740-01A-01D-1434-08	66308247	104464803	50805757	179	10301											
GUCY2F	2986	broad.mit.edu	37	chrX	108619355	108619355	+	Frame_Shift_Del	DEL	T	-	-																															ggaaggggcttcatgaagccTtttttcccaatcagccagaa																										TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chrX:108619355delT	uc004eod.3	-	18	3468	c.3192delA	c.(3190-3192)AAAfs	p.K1064fs	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	1064	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TCATGAAGCCTTTTTTCCCAA	0.418													---	---	---								-	108619355	-	-	108619355	7	5	51	1	0	1	0	1	0	0	0	0	6937	1606	56	0	142	0	GUCY2F	23	108619355	Frame_Shift_Del	DEL	T	TCGA-CN-4740-01A-01D-1434-08	4154552	108619355	46651205	180	10302											
ATP11C	286410	broad.mit.edu	37	chrX	138880468	138880468	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtttctgagatttcccttggTagttcaaagccattttggtt	7	18	9	7	0	2	1	1	1	1	1	3	2	3	1	2	2	1	4	2	2	2	8			TCGA-CN-4740-01A-01D-1434-08	TCGA-CN-4740-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	40308868-8d79-484b-85a4-257142763d72	c3927691-3146-425b-90b5-efd060a18cb6	g.chrX:138880468T>C	uc004faz.2	-	10	929	c.830A>G	c.(829-831)TAC>TGC	p.Y277C	ATP11C_uc004fay.2_5'Flank|ATP11C_uc004fba.2_Missense_Mutation_p.Y277C	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	277	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TTTCCCTTGGTAGTTCAAAGC	0.338													27	116					0	0	0	0	C	138880468	C	C	138880468	3	2	51	1	0	0	0	0	1	0	0	0	1123	1638	57	5	2715	5	ATP11C	23	138880468	Missense_Mutation	SNP	T	TCGA-CN-4740-01A-01D-1434-08	30261113	138880468	16390092	181	10303											
CDK11A	728642	broad.mit.edu	37	chr1	1635057	1635057	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gattttctcactgggggtccCcagctcctgaaagacagagg	9	9	12	11	0	1	3	1	1	1	2	4	4	3	3	3	3	1	1	3	3	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:1635057C>T	uc009vks.2	-	18	2026	c.1918G>A	c.(1918-1920)GGG>AGG	p.G640R	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_Missense_Mutation_p.G147R|CDK11A_uc009vkp.2_Missense_Mutation_p.G257R|CDK11A_uc009vkq.2_RNA|CDK11A_uc009vkr.2_Missense_Mutation_p.G630R	NM_024011	NP_076916	Q9UQ88	CD11A_HUMAN	cell division cycle 2-like 2 isoform 1	643	Protein kinase.				apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						CTGGGGGTCCCCAGCTCCTGA	0.572													3	7					0	0	0	0	T	1635057	T	T	1635057	3	4	52	1	0	0	0	0	1	0	0	0	3141	623	22	4	436	4	CDK11A	1	1635057	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08		1635057	247615564	1	10304											
FBLIM1	54751	broad.mit.edu	37	chr1	16096922	16096922	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacatctgtgccttctgccAcaagaccgtgtccccccgag	8	8	9	16	2	2	2	0	0	2	2	3	3	3	2	6	0	2	0	6	0	1	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:16096922A>G	uc001axd.1	+	7	1003	c.560A>G	c.(559-561)CAC>CGC	p.H187R	FBLIM1_uc001axe.1_Missense_Mutation_p.H187R|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axg.1_Missense_Mutation_p.H187R|FBLIM1_uc001axh.1_Missense_Mutation_p.H90R|FBLIM1_uc001axi.1_Missense_Mutation_p.H90R	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	187	LIM zinc-binding 1.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		GCCTTCTGCCACAAGACCGTG	0.637													35	50					0	0	0	0	G	16096922	G	G	16096922	3	3	52	1	0	0	0	0	1	0	0	0	5729	159	6	5	574	5	FBLIM1	1	16096922	Missense_Mutation	SNP	A	TCGA-CN-4741-01A-01D-1434-08	14461865	16096922	233153699	2	10305											
FBLIM1	54751	broad.mit.edu	37	chr1	16097009	16097009	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgtgccgcacctgccgccGccagctggctgggcagagct	5	5	14	17	4	0	1	0	0	0	1	0	1	0	1	5	2	4	5	5	2	0	0	rs138675454		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:16097009G>A	uc001axd.1	+	7	1090	c.647G>A	c.(646-648)CGC>CAC	p.R216H	FBLIM1_uc001axe.1_Missense_Mutation_p.R216H|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axg.1_Missense_Mutation_p.R216H|FBLIM1_uc001axh.1_Missense_Mutation_p.R119H|FBLIM1_uc001axi.1_Missense_Mutation_p.R119H	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	216	LIM zinc-binding 1.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		ACCTGCCGCCGCCAGCTGGCT	0.592													22	51					0	0	0	0	A	16097009	A	A	16097009	3	1	52	1	0	0	0	0	1	0	0	0	5729	1087	38	1	661	1	FBLIM1	1	16097009	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	87	16097009	233153612	3	10306											
UBR4	23352	broad.mit.edu	37	chr1	19436918	19436918	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgtcctccttggagataGaatccgtcagcagcagcatt	10	10	10	11	1	1	2	1	0	0	2	4	3	4	2	3	1	4	4	3	1	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:19436918G>T	uc001bbi.2	-	80	11937	c.11933C>A	c.(11932-11934)TCT>TAT	p.S3978Y		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3978					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CTTGGAGATAGAATCCGTCAG	0.537													28	60					1.06647e-15	1.2334e-15	1	0	T	19436918	T	T	19436918	3	4	52	1	0	0	0	0	1	0	0	0	16972	942	33	2	3726	2	UBR4	1	19436918	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	3339909	19436918	229813703	4	10307											
RAP1GAP	5909	broad.mit.edu	37	chr1	21924900	21924900	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttgtcctggtacctggggaGctgcccccactagtggtgct	4	11	13	13	0	0	0	0	0	0	0	1	1	1	1	4	4	4	3	4	4	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:21924900G>C	uc001bex.2	-	22	2130	c.1872C>G	c.(1870-1872)AGC>AGG	p.S624R	RAP1GAP_uc001bev.2_Missense_Mutation_p.S709R|RAP1GAP_uc001bew.2_Missense_Mutation_p.S688R|RAP1GAP_uc001bey.2_Missense_Mutation_p.S650R	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	624					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		TACCTGGGGAGCTGCCCCCAC	0.622													4	91					0	0	0	0	C	21924900	C	C	21924900	3	2	52	1	0	0	0	0	1	0	0	0	13102	962	34	4	131	4	RAP1GAP	1	21924900	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	2487982	21924900	227325721	5	10308											
TRIM63	84676	broad.mit.edu	37	chr1	26392775	26392775	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgacctggagcactcctgttTgtagatgtcgatgatgttct	7	14	11	9	2	1	2	0	1	1	1	3	5	2	3	2	1	1	4	2	1	1	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:26392775T>G	uc001bli.1	-	2	452	c.316A>C	c.(316-318)AAA>CAA	p.K106Q		NM_032588	NP_115977	Q969Q1	TRI63_HUMAN	muscle specific ring finger protein 1	106	Interaction with TTN.					cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CACTCCTGTTTGTAGATGTCG	0.622													3	162					0	0	0	0	G	26392775	G	G	26392775	3	3	52	1	0	0	0	0	1	0	0	0	16605	1821	63	5	777	5	TRIM63	1	26392775	Missense_Mutation	SNP	T	TCGA-CN-4741-01A-01D-1434-08	4467875	26392775	222857846	6	10309											
C1orf91	56063	broad.mit.edu	37	chr1	32682796	32682796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggagatgggttctgggaagGaactaacacaggtatgtcga	12	8	16	5	1	1	1	0	0	1	1	2	5	1	3	0	5	2	2	0	5	4	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:32682796G>A	uc009vub.1	-	4	395	c.392C>T	c.(391-393)TCC>TTC	p.S131F	C1orf91_uc001buo.3_Intron|C1orf91_uc001bup.3_Intron|C1orf91_uc010oha.1_Intron|C1orf91_uc001buq.3_Intron			Q8WY98	TM234_HUMAN	RecName: Full=UPF0546 membrane protein C1orf91;	Error:Variant_position_missing_in_Q8WY98_after_alignment						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TTCTGGGAAGGAACTAACACA	0.532													16	22					0	0	0	0	A	32682796	A	A	32682796	3	1	52	1	0	0	0	0	1	0	0	0	2078	1189	41	2		2	C1orf91	1	32682796	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	6290021	32682796	216567825	7	10310											
PLK3	1263	broad.mit.edu	37	chr1	45271192	45271192	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaccacaccaagctgattCtcagtggctgggagcccctc	8	7	12	14	0	1	1	1	1	1	0	3	3	1	3	4	3	2	2	4	3	1	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:45271192C>A	uc001cmn.2	+	15	1883	c.1783C>A	c.(1783-1785)CTC>ATC	p.L595I	PLK3_uc001cmo.2_RNA|BTBD19_uc010old.1_5'Flank|BTBD19_uc010ole.1_5'Flank	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	595	POLO box 2.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					CAAGCTGATTCTCAGTGGCTG	0.597													173	217					1.49245e-95	1.82946e-95	1	0	A	45271192	A	A	45271192	3	1	52	1	0	0	0	0	1	0	0	0	12152	913	32	2	1841	2	PLK3	1	45271192	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	12588396	45271192	203979429	8	10311											
UROD	7389	broad.mit.edu	37	chr1	45481099	45481099	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatgggctttatcctgacAtggacccagaacatgtgggc	9	9	12	11	0	0	2	0	1	0	1	1	3	1	3	3	3	1	1	3	3	2	2	rs142869188		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:45481099A>G	uc001cna.1	+	10	1141	c.1033A>G	c.(1033-1035)ATG>GTG	p.M345V	UROD_uc001cnb.1_Missense_Mutation_p.M310V|UROD_uc001cnc.1_Missense_Mutation_p.M250V	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	345						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					TTATCCTGACATGGACCCAGA	0.527									Porphyria_Cutanea_Tarda_Type_II				43	54					0	0	0	0	G	45481099	G	G	45481099	3	3	52	1	0	0	0	0	1	0	0	0	17097	217	8	5	1071	5	UROD	1	45481099	Missense_Mutation	SNP	A	TCGA-CN-4741-01A-01D-1434-08	209907	45481099	203769522	9	10312											
MAST2	23139	broad.mit.edu	37	chr1	46471917	46471917	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgttttcccctctagtcatCatgctcctcacaggaaaagc	10	12	6	13	0	4	0	3	0	1	0	6	1	6	1	3	1	2	2	3	1	3	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:46471917C>G	uc001cov.2	+	8	1035	c.752C>G	c.(751-753)TCA>TGA	p.S251*	MAST2_uc001cow.2_Nonsense_Mutation_p.S251*|MAST2_uc001cox.1_Nonsense_Mutation_p.S115*|MAST2_uc001coy.1_Translation_Start_Site|MAST2_uc001coz.1_Nonsense_Mutation_p.S136*|MAST2_uc009vya.2_Nonsense_Mutation_p.S173*|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	251					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CTCTAGTCATCATGCTCCTCA	0.478													7	282					0	0	0	0	G	46471917	G	G	46471917	4	3	52	1	0	0	0	0	0	1	0	0	9378	838	29	2	782	2	MAST2	1	46471917	Nonsense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	990818	46471917	202778704	10	10313											
DOCK7	85440	broad.mit.edu	37	chr1	62954604	62954604	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctagaaattggaatcattaCctgatgaacaattttgctga	14	13	8	6	0	1	4	1	3	0	1	1	5	1	5	1	1	3	2	1	1	6	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:62954604C>A	uc001daq.2	-	42	5500	c.5466_splice	c.e42+1	p.Q1822_splice	DOCK7_uc001dan.2_Splice_Site_p.Q1683_splice|DOCK7_uc001dao.2_Splice_Site_p.Q1683_splice|DOCK7_uc001dap.2_Splice_Site_p.Q1800_splice|DOCK7_uc001dam.2_Splice_Site_p.Q1002_splice|DOCK7_uc010oov.1_Splice_Site_p.Q561_splice	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7						activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						GGAATCATTACCTGATGAACA	0.353													18	67					1.15919e-05	1.27415e-05	1	0	A	62954604	A	A	62954604	5	1	52	1	0	0	0	0	0	0	1	0	4714	521	18	4	964	4	DOCK7	1	62954604	Splice_Site	SNP	C	TCGA-CN-4741-01A-01D-1434-08	16482687	62954604	186296017	11	10314											
LRRIQ3	127255	broad.mit.edu	37	chr1	74492542	74492542	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaaagtctaaatttgttttCacaattgctacttttgtttt	10	22	4	5	0	2	0	1	0	1	0	2	0	2	0	0	0	2	3	0	0	6	11			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:74492542C>T	uc001dfy.3	-	8	2022	c.1830G>A	c.(1828-1830)GTG>GTA	p.V610V	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	610	Potential.									ovary(2)	2						AATTTGTTTTCACAATTGCTA	0.284													26	38					0	0	0	0	T	74492542	T	T	74492542	2	4	52	1	0	0	0	0	0	0	0	1	9080	813	29	2		2	LRRIQ3	1	74492542	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	11537938	74492542	174758079	12	10315											
OLFM3	118427	broad.mit.edu	37	chr1	102312598	102312598	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggctggcagcgggaggcGtgactgcagcgcgccacatc	6	4	17	14	5	0	1	0	1	0	0	1	2	0	2	2	4	3	3	2	4	0	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:102312598G>A	uc001duf.2	-	1	3	c.-68C>T	c.(-70--66)CACGC>CATGC		OLFM3_uc001dug.2_Intron|OLFM3_uc001duh.2_Intron|OLFM3_uc001dui.2_Intron|OLFM3_uc001duj.2_Intron|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3							extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		AGCGGGAGGCGTGACTGCAGC	0.557													12	28					0	0	0	0	A	102312598	A	A	102312598	1	1	52	1	0	0	0	0	0	0	0	0	10908	1160	40	1		1	OLFM3	1	102312598	Translation_Start_Site	SNP	G	TCGA-CN-4741-01A-01D-1434-08	27820056	102312598	146938023	13	10316											
CELSR2	1952	broad.mit.edu	37	chr1	109794495	109794495	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctcggccagtgtcagcgtGactgtcctggatgtcaacga	7	9	13	12	3	2	1	2	1	0	0	4	3	3	2	3	2	2	0	3	2	1	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:109794495G>C	uc001dxa.3	+	1	1855	c.1794G>C	c.(1792-1794)GTG>GTC	p.V598V		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	598	Cadherin 4.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GTGTCAGCGTGACTGTCCTGG	0.562													4	77					0	0	0	0	C	109794495	C	C	109794495	2	2	52	1	0	0	0	0	0	0	0	1	3237	1277	45	2		2	CELSR2	1	109794495	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	7481897	109794495	139456126	14	10317											
C1orf162	128346	broad.mit.edu	37	chr1	112020686	112020686	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaagagcaatcacttggctGagaaccattctgcagacttt	14	10	8	9	0	2	3	1	1	1	3	2	4	2	3	1	1	3	3	1	1	4	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:112020686G>A	uc001ebe.2	+	6	469	c.409G>A	c.(409-411)GAG>AAG	p.E137K		NM_174896	NP_777556	Q8NEQ5	CA162_HUMAN	hypothetical protein LOC128346	137						integral to membrane				ovary(1)	1		all_cancers(81;0.00116)|all_epithelial(167;0.000761)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0236)|Colorectal(144;0.0286)|all cancers(265;0.0572)|Epithelial(280;0.0862)|COAD - Colon adenocarcinoma(174;0.112)|LUSC - Lung squamous cell carcinoma(189;0.134)		TCACTTGGCTGAGAACCATTC	0.428													6	151					0	0	0	0	A	112020686	A	A	112020686	3	1	52	1	0	0	0	0	1	0	0	0	2019	1291	45	2	427	2	C1orf162	1	112020686	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	2226191	112020686	137229935	15	10318											
TSPAN2	10100	broad.mit.edu	37	chr1	115604779	115604779	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccaagcacacattgcgactCccgcatggctccgcagcacc	9	6	8	18	3	0	0	0	0	0	0	3	1	3	0	4	1	3	5	4	1	1	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:115604779C>T	uc001eft.2	-	3	309	c.247G>A	c.(247-249)GAG>AAG	p.E83K		NM_005725	NP_005716	O60636	TSN2_HUMAN	tetraspan 2	83	Cytoplasmic (Potential).					integral to membrane					0	Lung SC(450;0.211)	all_cancers(81;2.9e-07)|all_epithelial(167;1.42e-06)|all_lung(203;6.72e-06)|Lung NSC(69;1.13e-05)|Acute lymphoblastic leukemia(138;0.191)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		CATTGCGACTCCCGCATGGCT	0.453													6	15					0	0	0	0	T	115604779	T	T	115604779	3	4	52	1	0	0	0	0	1	0	0	0	16711	864	30	2	442	2	TSPAN2	1	115604779	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	3584093	115604779	133645842	16	10319											
FLG	2312	broad.mit.edu	37	chr1	152284699	152284699	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctgcttgcacttctggatCctgactgcccacgggaggca	6	11	11	13	1	2	1	0	1	2	0	3	3	3	3	2	3	3	3	2	3	0	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:152284699C>A	uc001ezu.1	-	3	2699	c.2663G>T	c.(2662-2664)GGA>GTA	p.G888V	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	888	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTTCTGGATCCTGACTGCCC	0.562									Ichthyosis				38	750					1.52319e-26	1.83334e-26	1	0	A	152284699	A	A	152284699	3	1	52	1	0	0	0	0	1	0	0	0	5954	855	30	2	9526	2	FLG	1	152284699	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	36679920	152284699	96965922	17	10320											
PTPRC	5788	broad.mit.edu	37	chr1	198701643	198701643	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttgaactctctgagataaaCggagatgcagggtcaaacta	14	9	11	7	1	2	3	1	2	1	2	3	5	2	3	0	2	4	2	0	2	5	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:198701643C>T	uc001gur.1	+	20	2274	c.2094C>T	c.(2092-2094)AAC>AAT	p.N698N	PTPRC_uc001gus.1_Silent_p.N650N|PTPRC_uc001gut.1_Silent_p.N537N|PTPRC_uc009wzf.1_Silent_p.N586N|PTPRC_uc010ppg.1_Silent_p.N634N	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	698	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CTGAGATAAACGGAGATGCAG	0.318													16	27					0	0	0	0	T	198701643	T	T	198701643	2	4	52	1	0	0	0	0	0	0	0	1	12862	535	19	1		1	PTPRC	1	198701643	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	46416944	198701643	50548978	18	10321											
IGFN1	91156	broad.mit.edu	37	chr1	201195014	201195014	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcctgggacggtgacggccGagtgggaaccctctcctgac	6	7	15	13	3	1	2	0	2	1	0	2	5	1	4	4	4	2	0	4	4	1	0	rs79942057	byFrequency	TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:201195014G>A	uc001gwc.2	+	11	2801	c.2029G>A	c.(2029-2031)GAG>AAG	p.E677K	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						GGTGACGGCCGAGTGGGAACC	0.692													21	32					0	0	0	0	A	201195014	A	A	201195014	3	1	52	1	0	0	0	0	1	0	0	0	7629	1059	37	1	10631	1	IGFN1	1	201195014	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	2493371	201195014	48055607	19	10322											
TTC13	79573	broad.mit.edu	37	chr1	231064751	231064751	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggcaaatttttagcccaGtggtccttaaagcttccagg	12	11	9	9	0	0	0	0	0	0	0	2	0	2	0	3	3	2	2	3	3	5	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:231064751G>A	uc001huf.3	-	12	1420	c.1389C>T	c.(1387-1389)CAC>CAT	p.H463H	TTC13_uc009xfi.2_Silent_p.H410H|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Silent_p.H410H|TTC13_uc009xfk.1_Silent_p.H353H	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	463							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TTTTAGCCCAGTGGTCCTTAA	0.413													72	106					0	0	0	0	A	231064751	A	A	231064751	2	1	52	1	0	0	0	0	0	0	0	1	16748	1020	36	4		4	TTC13	1	231064751	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	29869737	231064751	18185870	20	10323											
SLC3A1	6519	broad.mit.edu	37	chr2	44547602	44547602	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggttaagtaccaattctgccGacaaaggcagtaaagttgat	14	10	10	7	1	1	1	0	1	1	0	1	2	1	1	2	2	2	5	2	2	6	5	rs146303355		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:44547602G>A	uc002ruc.3	+	10	1960	c.1882G>A	c.(1882-1884)GAC>AAC	p.D628N	PREPL_uc002ruf.2_3'UTR|PREPL_uc002rug.2_3'UTR|PREPL_uc002ruh.2_3'UTR|PREPL_uc010fax.2_3'UTR|PREPL_uc002rui.3_3'UTR|PREPL_uc002ruj.1_3'UTR|PREPL_uc002ruk.1_3'UTR|SLC3A1_uc002rud.3_Missense_Mutation_p.D350N|SLC3A1_uc002rue.3_Missense_Mutation_p.D248N	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	628	Extracellular (Potential).				carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	CAATTCTGCCGACAAAGGCAG	0.413													4	131					0	0	0	0	A	44547602	A	A	44547602	3	1	52	1	0	0	0	0	1	0	0	0	14690	1058	37	1	1920	1	SLC3A1	2	44547602	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08		44547602	198651771	21	10324											
EPAS1	2034	broad.mit.edu	37	chr2	46583923	46583923	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgcgaccatgaggagattCgtgagaacctgagtctcaaa	12	8	11	10	2	1	4	1	3	1	2	3	7	1	4	3	1	2	0	3	1	2	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:46583923C>T	uc002ruv.2	+	4	918	c.430C>T	c.(430-432)CGT>TGT	p.R144C		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	144	PAS 1.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			TGAGGAGATTCGTGAGAACCT	0.448													46	63					0	0	0	0	T	46583923	T	T	46583923	3	4	52	1	0	0	0	0	1	0	0	0	5174	884	31	1	444	1	EPAS1	2	46583923	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	2036321	46583923	196615450	22	10325											
USP34	9736	broad.mit.edu	37	chr2	61597495	61597495	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtcaatatgttgagtactCagtcgcccttctgctgccaa	9	12	8	12	1	3	1	2	1	1	0	4	1	3	1	2	0	3	3	2	0	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:61597495C>T	uc002sbe.2	-	10	1234	c.1212G>A	c.(1210-1212)CTG>CTA	p.L404L		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	404					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GTTGAGTACTCAGTCGCCCTT	0.244													6	198					0	0	0	0	T	61597495	T	T	61597495	2	4	52	1	0	0	0	0	0	0	0	1	17133	813	29	2		2	USP34	2	61597495	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	15013572	61597495	181601878	23	10326											
ACTG2	72	broad.mit.edu	37	chr2	74129548	74129548	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgaggctcagagcaagcGagggatcctaactctcaaat	13	7	12	9	1	2	2	2	1	1	1	4	5	3	4	1	3	3	2	1	3	3	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:74129548G>T	uc002sjw.2	+	3	310	c.188G>T	c.(187-189)CGA>CTA	p.R63L	ACTG2_uc010fex.1_Missense_Mutation_p.R63L|ACTG2_uc010fey.2_Missense_Mutation_p.R63L|ACTG2_uc010yrn.1_Intron	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	63					muscle contraction	cytoskeleton|cytosol	ATP binding				0						CAGAGCAAGCGAGGGATCCTA	0.483													30	46					2.4375e-19	2.86891e-19	1	0	T	74129548	T	T	74129548	3	4	52	1	0	0	0	0	1	0	0	0	197	1058	37	3	194	3	ACTG2	2	74129548	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	12532053	74129548	169069825	24	10327											
TUBA3D	113457	broad.mit.edu	37	chr2	132235898	132235898	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaacacgttcttcagtgaGactggagctggcaagcacgt	10	10	11	10	2	3	1	2	1	1	1	3	3	3	2	0	2	3	4	0	2	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:132235898G>C	uc002tsu.3	+	2	272	c.165G>C	c.(163-165)GAG>GAC	p.E55D		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	55					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		TCTTCAGTGAGACTGGAGCTG	0.557													18	58					0	0	0	0	C	132235898	C	C	132235898	3	2	52	1	0	0	0	0	1	0	0	0	16815	933	33	2	171	2	TUBA3D	2	132235898	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	58106350	132235898	110963475	25	10328											
DNAH7	56171	broad.mit.edu	37	chr2	196673458	196673458	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaagcgcataaactctctaCgaatggttttgaaggcaggc	12	11	10	8	2	1	1	0	1	1	0	2	2	1	1	0	3	3	3	0	3	6	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:196673458C>T	uc002utj.3	-	53	10132	c.10031G>A	c.(10030-10032)CGT>CAT	p.R3344H		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3344					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AAACTCTCTACGAATGGTTTT	0.373													4	163					0	0	0	0	T	196673458	T	T	196673458	3	4	52	1	0	0	0	0	1	0	0	0	4628	536	19	1	2095	1	DNAH7	2	196673458	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	64437560	196673458	46525915	26	10329											
TUBA4A	7277	broad.mit.edu	37	chr2	220116386	220116386	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatcctctttcccagtgatGagctgctctgggtggaagag	7	11	13	10	0	2	3	0	2	2	1	4	4	4	4	2	2	2	3	2	2	1	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:220116386G>A	uc002vkt.1	-	3	334	c.276C>T	c.(274-276)CTC>CTT	p.L92L	TUBA4A_uc010zkz.1_Silent_p.L77L|TUBA4B_uc002vku.2_5'Flank|TUBA4B_uc002vkv.1_5'Flank	NM_006000	NP_005991	P68366	TBA4A_HUMAN	tubulin, alpha 4a	92					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)	3		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCCAGTGATGAGCTGCTCTG	0.547													12	68					0	0	0	0	A	220116386	A	A	220116386	2	1	52	1	0	0	0	0	0	0	0	1	16817	1277	45	2		2	TUBA4A	2	220116386	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	23442928	220116386	23082987	27	10330											
SPEG	10290	broad.mit.edu	37	chr2	220338272	220338272	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgctggacaaaccagacatCgtgtatgtggtggagggaca	12	8	14	7	1	0	1	0	0	0	1	1	4	0	4	1	4	2	2	1	4	2	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:220338272C>T	uc010fwg.2	+	17	4194	c.4194C>T	c.(4192-4194)ATC>ATT	p.I1398I		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1398	Ig-like 7.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AACCAGACATCGTGTATGTGG	0.498													21	202					0	0	0	0	T	220338272	T	T	220338272	2	4	52	1	0	0	0	0	0	0	0	1	15102	874	31	1		1	SPEG	2	220338272	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	221886	220338272	22861101	28	10331											
SLC4A3	6508	broad.mit.edu	37	chr2	220501431	220501431	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccaggacctggagtacctCactggccgggtgtgggttgg	5	8	17	11	1	1	0	1	0	0	0	1	2	1	2	4	6	1	2	4	6	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:220501431C>G	uc002vmp.3	+	16	2639	c.2370C>G	c.(2368-2370)CTC>CTG	p.L790L	SLC4A3_uc002vmo.3_Silent_p.L817L|SLC4A3_uc010fwm.2_Silent_p.L340L|SLC4A3_uc010fwn.1_Silent_p.L299L	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	790	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGAGTACCTCACTGGCCGGG	0.642													4	144					0	0	0	0	G	220501431	G	G	220501431	2	3	52	1	0	0	0	0	0	0	0	1	14719	813	29	2		2	SLC4A3	2	220501431	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	163159	220501431	22697942	29	10332											
FARSB	10056	broad.mit.edu	37	chr2	223499180	223499180	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggcttgaatttgatatctGaaggacgctttgcagtataa	12	13	11	5	1	1	3	0	3	1	0	1	5	1	4	0	2	1	4	0	2	5	6			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:223499180G>A	uc002vne.1	-	6	571	c.536C>T	c.(535-537)TCA>TTA	p.S179L	FARSB_uc010zlq.1_Missense_Mutation_p.S199L|FARSB_uc002vnf.1_Missense_Mutation_p.S80L	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	179					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	TTTGATATCTGAAGGACGCTT	0.398													4	84					0	0	0	0	A	223499180	A	A	223499180	3	1	52	1	0	0	0	0	1	0	0	0	5712	1294	45	2	1281	2	FARSB	2	223499180	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	2997749	223499180	19700193	30	10333											
SACM1L	22908	broad.mit.edu	37	chr3	45744942	45744942	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcttaggcatatcacaccTgaaaaattttatgtggaagc	13	13	7	8	0	2	1	1	1	1	0	2	2	2	2	1	2	1	1	1	2	6	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:45744942T>C	uc003cos.2	+	2	249	c.45T>C	c.(43-45)CCT>CCC	p.P15P	SACM1L_uc011bag.1_5'UTR|SACM1L_uc011bah.1_5'UTR	NM_014016	NP_054735	Q9NTJ5	SAC1_HUMAN	suppressor of actin 1	15						Golgi apparatus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		ATATCACACCTGAAAAATTTT	0.348													3	125					0	0	0	0	C	45744942	C	C	45744942	2	2	52	1	0	0	0	0	0	0	0	1	13868	1567	55	5		5	SACM1L	3	45744942	Silent	SNP	T	TCGA-CN-4741-01A-01D-1434-08		45744942	152277488	31	10334											
CCR2	729230	broad.mit.edu	37	chr3	46399948	46399948	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctatgccttcgttggggaGaagttcagaaggtatctctc	9	13	11	8	1	3	2	1	0	2	2	6	3	3	2	1	3	1	3	1	3	4	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:46399948G>A	uc003cpn.3	+	2	1415	c.930G>A	c.(928-930)GAG>GAA	p.E310E	CCR2_uc003cpm.3_Silent_p.E310E	NM_001123041	NP_001116513	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2 isoform A	310	Cytoplasmic (Potential).				astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			lung(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		TCGTTGGGGAGAAGTTCAGAA	0.502													15	149					0	0	0	0	A	46399948	A	A	46399948	2	1	52	1	0	0	0	0	0	0	0	1	2956	933	33	2		2	CCR2	3	46399948	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	655006	46399948	151622482	32	10335											
DNAH1	25981	broad.mit.edu	37	chr3	52404531	52404531	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctgaaaagctgagtcgcatCgtagagttgatcgagccctg	10	10	12	9	3	1	4	0	3	1	1	4	5	1	4	1	0	2	4	1	0	3	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:52404531C>T	uc011bef.1	+	40	6558	c.6297C>T	c.(6295-6297)ATC>ATT	p.I2099I		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2099					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGAGTCGCATCGTAGAGTTGA	0.557													12	27					0	0	0	0	T	52404531	T	T	52404531	2	4	52	1	0	0	0	0	0	0	0	1	4619	874	31	1		1	DNAH1	3	52404531	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	6004583	52404531	145617899	33	10336											
TMEM110	375346	broad.mit.edu	37	chr3	52867433	52867433	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacaccgacggggcggcCgagccagcttgctctgtggg	6	6	16	13	4	1	1	0	1	1	0	1	3	1	1	3	4	4	2	3	4	1	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:52867433C>T	uc003dgc.3	-	10	1107	c.1026G>A	c.(1024-1026)TCG>TCA	p.S342S	ITIH4_uc011bem.1_5'Flank|ITIH4_uc011ben.1_5'Flank|ITIH4_uc003dfz.2_5'Flank|ITIH4_uc010hmp.1_5'Flank|MUSTN1_uc010hmq.1_RNA|MUSTN1_uc003dga.3_Silent_p.S52S|MUSTN1_uc003dgb.3_3'UTR	NM_198563	NP_940965	Q86TL2	TM110_HUMAN	transmembrane protein 110	Error:Variant_position_missing_in_Q86TL2_after_alignment						integral to membrane				large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)		ACGGGGCGGCCGAGCCAGCTT	0.602													22	25					0	0	0	0	T	52867433	T	T	52867433	2	4	52	1	0	0	0	0	0	0	0	1	16093	639	23	1		1	TMEM110	3	52867433	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	462902	52867433	145154997	34	10337											
DHFRL1	200895	broad.mit.edu	37	chr3	93780144	93780144	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgagaactaaattaattCtatcctttaaaggtcgattc	13	15	6	7	1	1	1	0	1	1	1	4	3	2	1	1	1	2	1	1	1	7	7			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:93780144C>T	uc003dri.2	-	2	378	c.212G>A	c.(211-213)AGA>AAA	p.R71K	DHFRL1_uc003drj.2_Missense_Mutation_p.R71K|NSUN3_uc003drk.2_5'Flank|NSUN3_uc003drl.1_5'Flank	NM_176815	NP_789785	Q86XF0	DYRL1_HUMAN	dihydrofolate reductase-like 1	71	DHFR.	Substrate (By similarity).			glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process		dihydrofolate reductase activity|NADP binding				0						TAAATTAATTCTATCCTTTAA	0.413													7	613					0	0	0	0	T	93780144	T	T	93780144	3	4	52	1	0	0	0	0	1	0	0	0	4504	913	32	2	355	2	DHFRL1	3	93780144	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	40912711	93780144	104242286	35	10338											
OR5H15	403274	broad.mit.edu	37	chr3	97887885	97887885	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaaccacagaatgttttctCttggcaacaatggcatatga	13	12	8	8	0	1	2	0	1	1	1	2	2	1	2	1	2	2	4	1	2	5	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:97887885C>G	uc011bgu.1	+	1	342	c.342C>G	c.(340-342)CTC>CTG	p.L114L		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AATGTTTTCTCTTGGCAACAA	0.378													4	562					0	0	0	0	G	97887885	G	G	97887885	2	3	52	1	0	0	0	0	0	0	0	1	11215	900	32	2		2	OR5H15	3	97887885	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	4107741	97887885	100134545	36	10339											
TOMM70A	9868	broad.mit.edu	37	chr3	100084508	100084508	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggccatctccatttccgatTtggccaggttaatagctttg	7	14	10	10	1	1	0	0	0	1	0	3	1	2	0	4	3	1	2	4	3	2	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:100084508T>G	uc003dtw.2	-	12	2159	c.1727A>C	c.(1726-1728)AAA>ACA	p.K576T		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	576	Cytoplasmic (Potential).|TPR 10.				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						CATTTCCGATTTGGCCAGGTT	0.398													5	455					0	0	0	0	G	100084508	G	G	100084508	3	3	52	1	0	0	0	0	1	0	0	0	16429	1841	64	5	103	5	TOMM70A	3	100084508	Missense_Mutation	SNP	T	TCGA-CN-4741-01A-01D-1434-08	2196623	100084508	97937922	37	10340											
TMPRSS7	344805	broad.mit.edu	37	chr3	111769615	111769615	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatcctccaaaatgcaagtgTacctggaaatttcaggtagc	13	11	8	9	0	1	0	1	0	0	0	3	1	3	1	3	2	3	3	3	2	7	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:111769615T>C	uc010hqb.2	+	7	980	c.810T>C	c.(808-810)TGT>TGC	p.C270C	TMPRSS7_uc011bhr.1_Silent_p.C125C	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	396	Extracellular (Potential).|CUB 2.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						AATGCAAGTGTACCTGGAAAT	0.353													111	559					0	0	0	0	C	111769615	C	C	111769615	2	2	52	1	0	0	0	0	0	0	0	1	16318	1644	57	5		5	TMPRSS7	3	111769615	Silent	SNP	T	TCGA-CN-4741-01A-01D-1434-08	11685107	111769615	86252815	38	10341											
EPHB1	2047	broad.mit.edu	37	chr3	134644682	134644682	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttaatggacaccagaacggCtactgcagagctgggctgga	11	7	14	9	1	0	2	0	0	0	2	0	4	0	4	1	4	4	5	1	4	3	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:134644682C>A	uc003eqt.2	+	2	303	c.83C>A	c.(82-84)GCT>GAT	p.A28D	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Missense_Mutation_p.A28D	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	28	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						ACCAGAACGGCTACTGCAGAG	0.458													3	29					6.4e-05	6.94857e-05	1	0	A	134644682	A	A	134644682	3	1	52	1	0	0	0	0	1	0	0	0	5198	797	28	4	89	4	EPHB1	3	134644682	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	22875067	134644682	63377748	39	10342											
CLSTN2	64084	broad.mit.edu	37	chr3	140178491	140178491	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagggtgccaaagtccccGatgggattgtgcccaagaac	10	6	14	11	1	0	1	0	0	0	1	1	3	1	2	4	3	3	1	4	3	3	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:140178491G>T	uc003etn.2	+	7	1292	c.1102G>T	c.(1102-1104)GAT>TAT	p.D368Y	CLSTN2_uc003etm.2_Missense_Mutation_p.D368Y	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	368	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CAAAGTCCCCGATGGGATTGT	0.577										HNSCC(16;0.037)			28	150					4.59853e-10	5.29528e-10	1	0	T	140178491	T	T	140178491	3	4	52	1	0	0	0	0	1	0	0	0	3577	1058	37	3	1128	3	CLSTN2	3	140178491	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	5533809	140178491	57843939	40	10343											
RSRC1	51319	broad.mit.edu	37	chr3	157921018	157921018	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagggaaggacaaggaattaCataacatcaaacgtgggtaa	19	6	11	5	1	1	0	1	0	0	0	1	3	1	3	0	4	3	1	0	4	8	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:157921018C>T	uc003fbt.2	+	4	589	c.478C>T	c.(478-480)CAT>TAT	p.H160Y	RSRC1_uc011bou.1_Intron|RSRC1_uc003fbu.1_Missense_Mutation_p.H160Y|RSRC1_uc003fbv.2_Intron	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	160					nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			caaggaATTACATAACATCAA	0.333													33	10					0	0	0	0	T	157921018	T	T	157921018	3	4	52	1	0	0	0	0	1	0	0	0	13779	478	17	4	488	4	RSRC1	3	157921018	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	17742527	157921018	40101412	41	10344											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			30	218					0	0	0	0	A	178936091	A	A	178936091	3	1	52	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	21015073	178936091	19086339	42	10345											
YEATS2	55689	broad.mit.edu	37	chr3	183471980	183471980	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgccatcttcattggaaaGaacacccaccaaaatgacta	15	10	5	11	0	2	2	1	1	1	1	2	3	2	3	3	1	2	0	3	1	5	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:183471980G>C	uc003fly.2	+	11	1412	c.1217G>C	c.(1216-1218)AGA>ACA	p.R406T		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	406					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCATTGGAAAGAACACCCACC	0.443													12	761					0	0	0	0	C	183471980	C	C	183471980	3	2	52	1	0	0	0	0	1	0	0	0	17540	942	33	2	1255	2	YEATS2	3	183471980	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	4535889	183471980	14550450	43	10346											
ECE2	9718	broad.mit.edu	37	chr3	184008348	184008348	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cactcttcctccgccaggtgGagcatgaccccccagacagt	8	7	9	17	1	1	2	0	1	1	1	3	3	3	3	6	2	1	1	6	2	0	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:184008348G>A	uc003fni.3	+	15	2051	c.2013G>A	c.(2011-2013)TGG>TGA	p.W671*	ECE2_uc011brh.1_Nonsense_Mutation_p.W524*|ECE2_uc003fnl.3_Nonsense_Mutation_p.W599*|ECE2_uc003fnm.3_Nonsense_Mutation_p.W553*|ECE2_uc003fnk.3_Nonsense_Mutation_p.W524*|ECE2_uc011bri.1_Nonsense_Mutation_p.W586*|ECE2_uc010hxv.2_Nonsense_Mutation_p.W315*	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	671	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCGCCAGGTGGAGCATGACCC	0.622													14	522					0	0	0	0	A	184008348	A	A	184008348	4	1	52	1	0	0	0	0	0	1	0	0	4912	1183	41	2	2635	2	ECE2	3	184008348	Nonsense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	536368	184008348	14014082	44	10347											
BCL6	604	broad.mit.edu	37	chr3	187447102	187447102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggggtcagtggggctcttgGctggaggggagccagaagcc	6	7	20	8	0	2	1	1	0	1	1	2	3	2	3	2	8	2	2	2	8	1	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:187447102G>A	uc003frp.3	-	5	1548	c.1091C>T	c.(1090-1092)GCC>GTC	p.A364V	BCL6_uc011bsf.1_Missense_Mutation_p.A364V|BCL6_uc010hza.2_Missense_Mutation_p.A262V|BCL6_uc003frq.1_Missense_Mutation_p.A364V	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	364					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		GGGGCTCTTGGCTGGAGGGGA	0.577			T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								21	869					0	0	0	0	A	187447102	A	A	187447102	3	1	52	1	0	0	0	0	1	0	0	0	1378	1203	42	4	1053	4	BCL6	3	187447102	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	3438754	187447102	10575328	45	10348											
MUC4	4585	broad.mit.edu	37	chr3	195486032	195486032	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcagctgtctctgagcgtGaagttggcatcctcagcatt	7	12	12	10	1	2	2	1	2	1	0	4	2	3	2	1	1	4	5	1	1	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:195486032G>A	uc011bto.1	-	18	15025	c.14565C>T	c.(14563-14565)TTC>TTT	p.F4855F	MUC4_uc003fuz.2_Silent_p.F581F|MUC4_uc003fva.2_Silent_p.F463F|MUC4_uc003fvb.2_Silent_p.F499F|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Silent_p.F499F|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Silent_p.F463F|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Silent_p.F547F|MUC4_uc011bti.1_Silent_p.F547F|MUC4_uc011btj.1_Silent_p.F724F|MUC4_uc011btk.1_Silent_p.F463F|MUC4_uc011btl.1_Silent_p.F492F|MUC4_uc011btm.1_Silent_p.F672F|MUC4_uc011btn.1_Silent_p.F463F|MUC4_uc003fvo.2_Silent_p.F747F|MUC4_uc003fvp.2_Silent_p.F696F	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1740					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CTCTGAGCGTGAAGTTGGCAT	0.552													8	891					0	0	0	0	A	195486032	A	A	195486032	2	1	52	1	0	0	0	0	0	0	0	1	10031	1281	45	2		2	MUC4	3	195486032	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	8038930	195486032	2536398	46	10349											
MUC4	4585	broad.mit.edu	37	chr3	195517519	195517519	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcctgagtagaagtccttGagaaagttgctggtgattgt	9	14	13	5	0	0	4	0	3	0	2	2	5	2	4	2	1	1	3	2	1	3	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:195517519G>C	uc011bto.1	-	2	1392	c.932C>G	c.(931-933)TCA>TGA	p.S311*	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Nonsense_Mutation_p.S193*	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	316					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGAAGTCCTTGAGAAAGTTGC	0.473													6	606					0	0	0	0	C	195517519	C	C	195517519	4	2	52	1	0	0	0	0	0	1	0	0	10031	1294	45	2		2	MUC4	3	195517519	Nonsense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	31487	195517519	2504911	47	10350											
LRCH3	84859	broad.mit.edu	37	chr3	197585712	197585712	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttgaaatgtagtcgctgtCagggttgaatcaagtgggct	10	13	13	5	1	2	2	2	2	0	0	3	2	2	2	0	2	0	4	0	2	4	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:197585712C>T	uc011bul.1	+	15	1657	c.1652C>T	c.(1651-1653)TCA>TTA	p.S551L	LRCH3_uc003fyj.1_Missense_Mutation_p.S551L|LRCH3_uc011bum.1_Intron|LRCH3_uc011bun.1_Missense_Mutation_p.S397L|LRCH3_uc003fyk.2_Missense_Mutation_p.S146L	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	551						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		TAGTCGCTGTCAGGGTTGAAT	0.438													86	415					0	0	0	0	T	197585712	T	T	197585712	3	4	52	1	0	0	0	0	1	0	0	0	8984	838	29	2	1710	2	LRCH3	3	197585712	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	2068193	197585712	436718	48	10351											
APBB2	323	broad.mit.edu	37	chr4	40936491	40936491	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accttggcttctgggtcactGttgatactacaagaatcatc	10	13	8	10	0	3	2	2	1	1	1	4	2	3	2	1	2	2	2	1	2	4	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:40936491G>A	uc003gvl.2	-	10	1863	c.1233C>T	c.(1231-1233)AAC>AAT	p.N411N	APBB2_uc010ifu.2_5'UTR|APBB2_uc003gvm.2_Silent_p.N390N|APBB2_uc003gvn.2_Silent_p.N412N|APBB2_uc011byt.1_Silent_p.N373N	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	411					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						CTGGGTCACTGTTGATACTAC	0.383													16	88					0	0	0	0	A	40936491	A	A	40936491	2	1	52	1	0	0	0	0	0	0	0	1	761	1368	48	4		4	APBB2	4	40936491	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08		40936491	150217785	49	10352											
TXK	7294	broad.mit.edu	37	chr4	48096216	48096216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatgttttatggcagcctccGtacttctacaatcaagaaaa	14	12	6	9	1	2	1	1	0	1	1	3	1	3	1	2	1	3	3	2	1	8	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:48096216G>A	uc003gxx.3	-	8	673	c.587C>T	c.(586-588)ACG>ATG	p.T196M	TXK_uc003gxy.1_Missense_Mutation_p.T196M	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	196	SH2.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GGCAGCCTCCGTACTTCTACA	0.373													8	58					0	0	0	0	A	48096216	A	A	48096216	3	1	52	1	0	0	0	0	1	0	0	0	16854	1145	40	1	1028	1	TXK	4	48096216	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	7159725	48096216	143058060	50	10353											
PDHA2	5161	broad.mit.edu	37	chr4	96762282	96762282	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaatggtaaacagcaagctCgccactgtggaagaattaaa	17	7	10	7	1	0	2	0	0	0	2	1	3	0	3	1	2	3	3	1	2	8	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:96762282C>T	uc003htr.3	+	1	1044	c.981C>T	c.(979-981)CTC>CTT	p.L327L		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	327					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	ACAGCAAGCTCGCCACTGTGG	0.428													40	53					0	0	0	0	T	96762282	T	T	96762282	2	4	52	1	0	0	0	0	0	0	0	1	11719	871	31	1		1	PDHA2	4	96762282	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	48666066	96762282	94391994	51	10354											
FAT4	79633	broad.mit.edu	37	chr4	126371107	126371107	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatagtggacagtaatgacaAtgcacctcaatttcttaaaa	16	12	6	7	0	2	1	1	1	1	0	2	2	2	2	1	1	1	2	1	1	7	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:126371107A>T	uc003ifj.3	+	9	8936	c.8936A>T	c.(8935-8937)AAT>ATT	p.N2979I	FAT4_uc011cgp.1_Missense_Mutation_p.N1277I|FAT4_uc003ifi.1_Missense_Mutation_p.N457I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2979	Cadherin 28.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGTAATGACAATGCACCTCAA	0.343													37	65					0	0	0	0	T	126371107	T	T	126371107	3	4	52	1	0	0	0	0	1	0	0	0	5724	101	4	5	8970	5	FAT4	4	126371107	Missense_Mutation	SNP	A	TCGA-CN-4741-01A-01D-1434-08	29608825	126371107	64783169	52	10355											
MAP9	79884	broad.mit.edu	37	chr4	156274418	156274418	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctttttggcagctattttCtttgcttccttttctttcat	3	24	4	10	0	4	0	1	0	3	0	5	0	5	0	1	1	2	3	1	1	1	10			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:156274418C>G	uc003ios.2	-	11	1719	c.1455G>C	c.(1453-1455)AAG>AAC	p.K485N	MAP9_uc011cin.1_Missense_Mutation_p.K460N|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.K484N	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	485	Potential.				cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CAGCTATTTTCTTTGCTTCCT	0.353													8	119					0	0	0	0	G	156274418	G	G	156274418	3	3	52	1	0	0	0	0	1	0	0	0	9323	912	32	2	504	2	MAP9	4	156274418	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	29903311	156274418	34879858	53	10356											
MAP9	79884	broad.mit.edu	37	chr4	156289952	156289952	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgatcatctgtgtcaaggCtgttgttttctgctgaaaaa	10	15	10	6	0	4	2	2	2	2	0	4	2	4	2	0	1	1	4	0	1	3	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:156289952C>A	uc003ios.2	-	5	758	c.494G>T	c.(493-495)AGC>ATC	p.S165I	MAP9_uc011cin.1_Missense_Mutation_p.S164I|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.S164I|MAP9_uc010iqb.1_Missense_Mutation_p.S92I	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	165					cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TGTGTCAAGGCTGTTGTTTTC	0.388													38	69					6.21074e-16	7.21422e-16	1	0	A	156289952	A	A	156289952	3	1	52	1	0	0	0	0	1	0	0	0	9323	797	28	4	1489	4	MAP9	4	156289952	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	15534	156289952	34864324	54	10357											
PDGFC	56034	broad.mit.edu	37	chr4	157771474	157771474	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actaatctccataccaagacCgtatttcttggataagtatg	13	13	6	9	1	2	1	0	0	2	1	3	2	2	2	3	1	1	2	3	1	6	7			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:157771474C>G	uc003iph.1	-	2	704	c.213G>C	c.(211-213)ACG>ACC	p.T71T	PDGFC_uc003ipi.1_5'UTR|PDGFC_uc011cis.1_Intron|PDGFC_uc011cir.1_5'UTR	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	71	CUB.				central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		ATACCAAGACCGTATTTCTTG	0.388													41	67					0	0	0	0	G	157771474	G	G	157771474	2	3	52	1	0	0	0	0	0	0	0	1	11713	639	23	3		3	PDGFC	4	157771474	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	1481522	157771474	33382802	55	10358											
SDHA	6389	broad.mit.edu	37	chr5	233625	233625	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggttgtctcattacggaagGatgtcgtggagagggaggca	9	10	17	5	2	1	1	1	0	1	1	3	5	1	4	0	6	1	2	0	6	2	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:233625G>A	uc003jao.3	+	8	1044	c.929G>A	c.(928-930)GGA>GAA	p.G310E	SDHA_uc003jan.2_Missense_Mutation_p.G310E|SDHA_uc011clv.1_Missense_Mutation_p.G310E|SDHA_uc011clw.1_Missense_Mutation_p.G262E|SDHA_uc003jap.3_Missense_Mutation_p.G310E|SDHA_uc003jaq.3_Missense_Mutation_p.G85E|SDHA_uc003jar.3_5'UTR	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	310					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	ATTACGGAAGGATGTCGTGGA	0.438									Familial_Paragangliomas				93	150					0	0	0	0	A	233625	A	A	233625	3	1	52	1	0	0	0	0	1	0	0	0	14028	1174	41	2	959	2	SDHA	5	233625	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08		233625	180681635	56	10359											
CTNND2	1501	broad.mit.edu	37	chr5	11732259	11732259	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttctacctgttctttgaCtgaggcgaggatggcagagg	7	13	14	7	1	2	3	0	2	2	1	2	5	2	4	1	4	1	3	1	4	1	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:11732259C>A	uc003jfa.1	-	2	308	c.163G>T	c.(163-165)GTC>TTC	p.V55F	CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	55	Potential.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGTTCTTTGACTGAGGCGAGG	0.423													66	104					2.15316e-23	2.57992e-23	1	0	A	11732259	A	A	11732259	3	1	52	1	0	0	0	0	1	0	0	0	4037	565	20	4	3598	4	CTNND2	5	11732259	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	11498634	11732259	169183001	57	10360											
CDH10	1008	broad.mit.edu	37	chr5	24511507	24511507	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacatatcagtaccgtcacCatcaataattcggtattcta	15	12	4	10	2	4	0	3	0	1	0	5	0	4	0	2	1	2	2	2	1	7	7			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:24511507C>A	uc003jgr.1	-	6	1263	c.931G>T	c.(931-933)GGT>TGT	p.G311C	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	311	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GTACCGTCACCATCAATAATT	0.433										HNSCC(23;0.051)			87	161					1.79992e-35	2.19623e-35	1	0	A	24511507	A	A	24511507	3	1	52	1	0	0	0	0	1	0	0	0	3111	594	21	4	1463	4	CDH10	5	24511507	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	12779248	24511507	156403753	58	10361											
CDH9	1007	broad.mit.edu	37	chr5	26881576	26881576	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tactgtcttctcttgcctctGgattccttaatgtgccaatg	6	17	7	11	0	3	0	0	0	3	0	5	1	4	1	3	1	3	0	3	1	3	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:26881576G>T	uc003jgs.1	-	12	2208	c.2039C>A	c.(2038-2040)CCA>CAA	p.P680Q	CDH9_uc011cnv.1_Missense_Mutation_p.P273Q	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	680	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TCTTGCCTCTGGATTCCTTAA	0.433													14	267					1.49906e-05	1.64095e-05	1	0	T	26881576	T	T	26881576	3	4	52	1	0	0	0	0	1	0	0	0	3132	1348	47	4	334	4	CDH9	5	26881576	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	2370069	26881576	154033684	59	10362											
C6	729	broad.mit.edu	37	chr5	41199909	41199909	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcttgcagtcagcctcttCaattttgcagagcttagatg	9	15	8	9	0	4	2	2	0	2	2	4	2	4	2	1	0	4	3	1	0	2	6			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:41199909C>A	uc003jmk.2	-	4	616	c.406G>T	c.(406-408)GAA>TAA	p.E136*	C6_uc003jml.1_Nonsense_Mutation_p.E136*	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	136					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TCAGCCTCTTCAATTTTGCAG	0.428													5	154					0.000602214	0.000648539	1	0	A	41199909	A	A	41199909	4	1	52	1	0	0	0	0	0	1	0	0	2325	835	29	2	2458	2	C6	5	41199909	Nonsense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	14318333	41199909	139715351	60	10363											
KCNN2	3781	broad.mit.edu	37	chr5	113699624	113699624	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtcgctgtattccttagctCtgaaatgccttatcagtctc	7	15	7	12	2	3	1	1	1	2	0	6	1	4	1	2	0	2	3	2	0	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:113699624C>T	uc003kqo.2	+	2	965	c.508C>T	c.(508-510)CTG>TTG	p.L170L		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	170	Helical; Name=Segment S2; (Potential).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TTCCTTAGCTCTGAAATGCCT	0.483													43	84					0	0	0	0	T	113699624	T	T	113699624	2	4	52	1	0	0	0	0	0	0	0	1	8118	912	32	2		2	KCNN2	5	113699624	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	72499715	113699624	67215636	61	10364											
CEP120	153241	broad.mit.edu	37	chr5	122682331	122682331	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtatccctttcttctatcAggcgagtcaaataatcatcc	12	13	5	11	1	5	0	3	0	2	0	7	1	7	0	2	1	0	1	2	1	5	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:122682331A>G	uc003ktk.2	-	21	2925	c.2843T>C	c.(2842-2844)CTG>CCG	p.L948P	CEP120_uc011cwq.1_Missense_Mutation_p.L757P	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	948						centrosome				ovary(1)	1						TTCTTCTATCAGGCGAGTCAA	0.418													4	290					0	0	0	0	G	122682331	G	G	122682331	3	3	52	1	0	0	0	0	1	0	0	0	3261	188	7	5	121	5	CEP120	5	122682331	Missense_Mutation	SNP	A	TCGA-CN-4741-01A-01D-1434-08	8982707	122682331	58232929	62	10365											
PCDHGA1	56114	broad.mit.edu	37	chr5	140711638	140711638	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctactctgcctacattcccGaaaacaaccccagaggagcc	12	6	6	17	1	1	1	0	0	1	1	2	3	2	2	6	1	6	0	6	1	5	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:140711638G>A	uc003lji.1	+	1	1387	c.1387G>A	c.(1387-1389)GAA>AAA	p.E463K	PCDHGA1_uc011dan.1_Missense_Mutation_p.E463K	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	463	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACATTCCCGAAAACAACCC	0.468													68	123					0	0	0	0	A	140711638	A	A	140711638	3	1	52	1	0	0	0	0	1	0	0	0	11604	1059	37	1	1389	1	PCDHGA1	5	140711638	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	18029307	140711638	40203622	63	10366											
C5orf58	133874	broad.mit.edu	37	chr5	169673114	169673114	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttctaacagtttttctatCtgatttcttatttgttatga	8	23	5	5	0	4	2	0	2	4	0	4	2	4	2	0	0	1	3	0	0	4	9			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:169673114C>G	uc010jjn.2	+	4	389	c.306C>G	c.(304-306)ATC>ATG	p.I102M	C5orf58_uc003mal.2_Intron	NM_001102609	NP_001096079	C9J3I9	CE058_HUMAN	hypothetical protein LOC133874	102											0						GTTTTTCTATCTGATTTCTTA	0.289													3	75					0	0	0	0	G	169673114	G	G	169673114	3	3	52	1	0	0	0	0	1	0	0	0	2323	903	32	2	316	2	C5orf58	5	169673114	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	28961476	169673114	11242146	64	10367											
RUFY1	80230	broad.mit.edu	37	chr5	178987158	178987158	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgcccccttgcagcagtTctttgtagtgatggagcact	7	12	10	12	0	1	1	0	1	1	0	1	2	1	2	3	1	4	5	3	1	1	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:178987158T>C	uc003mka.1	+	2	443	c.443T>C	c.(442-444)TTC>TCC	p.F148S	RUFY1_uc003mkb.1_Missense_Mutation_p.F40S|RUFY1_uc003mkc.1_Missense_Mutation_p.F40S	NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	148	RUN.				endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTGCAGCAGTTCTTTGTAGTG	0.572										HNSCC(44;0.11)			14	25					0	0	0	0	C	178987158	C	C	178987158	3	2	52	1	0	0	0	0	1	0	0	0	13803	1783	62	5	449	5	RUFY1	5	178987158	Missense_Mutation	SNP	T	TCGA-CN-4741-01A-01D-1434-08	9314044	178987158	1928102	65	10368											
MAML1	9794	broad.mit.edu	37	chr5	179201801	179201801	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtggctggacacaccgatCtgatcgactccctgctgaag	8	9	12	12	2	1	2	0	2	1	0	3	5	2	3	2	2	1	2	2	2	1	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:179201801C>T	uc003mkm.2	+	5	3237	c.2974C>T	c.(2974-2976)CTG>TTG	p.L992L	MAML1_uc003mkn.1_Intron	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	992					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACACACCGATCTGATCGACTC	0.557													5	107					0	0	0	0	T	179201801	T	T	179201801	2	4	52	1	0	0	0	0	0	0	0	1	9258	912	32	2		2	MAML1	5	179201801	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	214643	179201801	1713459	66	10369											
PRPF4B	8899	broad.mit.edu	37	chr6	4032653	4032653	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccagttgatttaagaggtaAatccaaagacagaaggtcac	16	8	9	8	0	1	4	1	1	0	3	2	4	2	4	2	2	0	2	2	2	5	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:4032653A>G	uc003mvv.2	+	2	993	c.902A>G	c.(901-903)AAA>AGA	p.K301R	PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	301	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TTAAGAGGTAAATCCAAAGAC	0.353													122	30					0	0	0	0	G	4032653	G	G	4032653	3	3	52	1	0	0	0	0	1	0	0	0	12635	14	1	5	908	5	PRPF4B	6	4032653	Missense_Mutation	SNP	A	TCGA-CN-4741-01A-01D-1434-08		4032653	167082414	67	10370											
PRPF4B	8899	broad.mit.edu	37	chr6	4044117	4044117	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagcagcccccagagcagtaCgagaacacgatcaccatctc	14	4	8	15	2	2	2	1	0	1	2	3	4	2	2	3	0	5	3	3	0	3	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:4044117C>T	uc003mvv.2	+	6	1812	c.1721C>T	c.(1720-1722)ACG>ATG	p.T574M	PRPF4B_uc003mvw.2_RNA|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	574						catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CAGAGCAGTACGAGAACACGA	0.418													60	20					0	0	0	0	T	4044117	T	T	4044117	3	4	52	1	0	0	0	0	1	0	0	0	12635	536	19	1	1743	1	PRPF4B	6	4044117	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	11464	4044117	167070950	68	10371											
BAT2	7916	broad.mit.edu	37	chr6	31605326	31605326	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcagaggagcctgggtcccGaggggacaaggagcctgggt	8	4	20	9	1	0	1	0	0	0	1	1	5	1	4	3	7	2	1	3	7	1	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:31605326G>A	uc003nvb.3	+	31	6686	c.6437G>A	c.(6436-6438)CGA>CAA	p.R2146Q	BAT2_uc003nvc.3_Missense_Mutation_p.R2146Q	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	2146						cytoplasm|nucleus	protein binding				0						CCTGGGTCCCGAGGGGACAAG	0.632													6	84					0	0	0	0	A	31605326	A	A	31605326	3	1	52	1	0	0	0	0	1	0	0	0	1321	1058	37	1	6555	1	BAT2	6	31605326	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	27561209	31605326	139509741	69	10372											
TREML2	79865	broad.mit.edu	37	chr6	41162432	41162432	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagagcctaggcaaggtgatGagtcctggggtgaacaccat	12	7	14	8	0	0	4	0	3	0	1	1	4	1	4	3	4	2	1	3	4	4	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:41162432G>C	uc010jxm.1	-	3	695	c.516C>G	c.(514-516)CTC>CTG	p.L172L		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	172	Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCAAGGTGATGAGTCCTGGGG	0.577													7	40					0	0	0	0	C	41162432	C	C	41162432	2	2	52	1	0	0	0	0	0	0	0	1	16540	1277	45	2		2	TREML2	6	41162432	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	9557106	41162432	129952635	70	10373											
DEFB114	245928	broad.mit.edu	37	chr6	49928019	49928019	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttttcaaaacatatcatCttcttcatacaatttctcag	12	18	1	10	0	7	0	4	0	4	0	8	0	7	0	0	0	2	0	0	0	5	8			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:49928019C>G	uc011dwp.1	-	2	196	c.196G>C	c.(196-198)GAT>CAT	p.D66H		NM_001037499	NP_001032588	Q30KQ6	DB114_HUMAN	beta-defensin 114 precursor	66					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					AACATATCATCTTCTTCATAC	0.358													17	39					0	0	0	0	G	49928019	G	G	49928019	3	3	52	1	0	0	0	0	1	0	0	0	4424	913	32	2	16	2	DEFB114	6	49928019	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	8765587	49928019	121187048	71	10374											
SENP6	26054	broad.mit.edu	37	chr6	76376512	76376512	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcagcctgctgattcagcatGttcttcccctgcaccatcca	7	12	6	16	0	3	1	2	1	1	0	5	1	5	1	5	0	4	4	5	0	0	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:76376512G>C	uc003pid.3	+	10	1698	c.1079G>C	c.(1078-1080)TGT>TCT	p.C360S	SENP6_uc003pie.3_Missense_Mutation_p.C353S|SENP6_uc010kbf.2_RNA|SENP6_uc003pic.2_Missense_Mutation_p.C353S|SENP6_uc003pif.1_Missense_Mutation_p.C251S	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	360					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				GATTCAGCATGTTCTTCCCCT	0.423													20	87					0	0	0	0	C	76376512	C	C	76376512	3	2	52	1	0	0	0	0	1	0	0	0	14115	1377	48	4	1117	4	SENP6	6	76376512	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	26448493	76376512	94738555	72	10375											
IBTK	25998	broad.mit.edu	37	chr6	82923970	82923970	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcaaattactgaagtcgaaTttctttgcaacagtttgcaa	13	14	6	8	1	2	1	1	1	1	0	3	2	2	1	0	0	4	3	0	0	6	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:82923970T>C	uc003pjl.1	-	12	2705	c.2178A>G	c.(2176-2178)AAA>AAG	p.K726K	IBTK_uc011dyv.1_Silent_p.K726K|IBTK_uc011dyw.1_Intron|IBTK_uc010kbi.1_Silent_p.K420K|IBTK_uc003pjm.2_Silent_p.K726K	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	726					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TGAAGTCGAATTTCTTTGCAA	0.338													42	69					0	0	0	0	C	82923970	C	C	82923970	2	2	52	1	0	0	0	0	0	0	0	1	7515	1490	52	5		5	IBTK	6	82923970	Silent	SNP	T	TCGA-CN-4741-01A-01D-1434-08	6547458	82923970	88191097	73	10376											
CDC40	51362	broad.mit.edu	37	chr6	110530349	110530349	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaaagtttaaagaaaatGatgcatccaatattgatggt	18	11	9	3	0	0	3	0	2	0	1	1	4	1	4	1	2	1	2	1	2	8	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:110530349G>T	uc003pua.2	+	5	577	c.553G>T	c.(553-555)GAT>TAT	p.D185Y		NM_015891	NP_056975	O60508	PRP17_HUMAN	cell division cycle 40 homolog	185					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)		TAAAGAAAATGATGCATCCAA	0.299													6	70					5.9392e-07	6.61016e-07	1	0	T	110530349	T	T	110530349	3	4	52	1	0	0	0	0	1	0	0	0	3085	1290	45	2	571	2	CDC40	6	110530349	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	27606379	110530349	60584718	74	10377											
C6orf97	80129	broad.mit.edu	37	chr6	151894461	151894461	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgagttggagaagagtttGaaggccagtcaggatgcagt	11	10	15	5	0	2	4	1	2	1	2	2	6	2	5	1	3	1	3	1	3	2	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:151894461G>C	uc003qol.2	+	6	1016	c.927G>C	c.(925-927)TTG>TTC	p.L309F		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	309											0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		AGAAGAGTTTGAAGGCCAGTC	0.512													3	72					0	0	0	0	C	151894461	C	C	151894461	3	2	52	1	0	0	0	0	1	0	0	0	2385	1281	45	2	949	2	C6orf97	6	151894461	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	41364112	151894461	19220606	75	10378											
C6orf70	55780	broad.mit.edu	37	chr6	170151655	170151655	+	5'Flank	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagtctcccacctgcgcctcGtacggtaggaagtgcccgcc	7	7	11	16	4	1	0	0	0	1	0	3	1	1	1	5	2	3	2	5	2	4	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:170151655G>T	uc003qxg.1	+						TCTE3_uc003qxe.1_5'Flank|TCTE3_uc003qxf.2_RNA|C6orf70_uc011ehb.1_5'Flank|C6orf70_uc003qxh.1_5'Flank|C6orf70_uc010kky.1_5'Flank	NM_018341	NP_060811	Q5T6L9	CF070_HUMAN	hypothetical protein LOC55780							integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		CCTGCGCCTCGTACGGTAGGA	0.701													7	12					1.12685e-05	1.24374e-05	1	0	T	170151655	T	T	170151655	1	4	52	0	1	0	0	0	0	0	0	0	2380	1160	40	3		3	C6orf70	6	170151655	5'Flank	SNP	G	TCGA-CN-4741-01A-01D-1434-08	18257194	170151655	963412	76	10379											
THSD7A	221981	broad.mit.edu	37	chr7	11468681	11468681	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacaggacttgctgcagcGcgaccagttggaccactcac	9	6	10	16	2	1	0	1	0	0	0	1	3	1	2	3	2	3	3	3	2	0	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:11468681G>A	uc003ssf.3	-	14	3388	c.3136C>T	c.(3136-3138)CGC>TGC	p.R1046C		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1046	TSP type-1 11.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTGCTGCAGCGCGACCAGTTG	0.517										HNSCC(18;0.044)			110	166					0	0	0	0	A	11468681	A	A	11468681	3	1	52	1	0	0	0	0	1	0	0	0	15945	1087	38	1	1893	1	THSD7A	7	11468681	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08		11468681	147669982	77	10380											
THSD7A	221981	broad.mit.edu	37	chr7	11676072	11676072	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attggcacacctggaactccGtcaggtttggacagccagag	10	8	12	11	1	1	1	1	0	0	1	2	3	2	3	3	4	2	2	3	4	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:11676072G>A	uc003ssf.3	-	2	959	c.707C>T	c.(706-708)ACG>ATG	p.T236M		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	236	Extracellular (Potential).|TSP type-1 2.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTGGAACTCCGTCAGGTTTGG	0.657										HNSCC(18;0.044)			4	38					0	0	0	0	A	11676072	A	A	11676072	3	1	52	1	0	0	0	0	1	0	0	0	15945	1145	40	1	4370	1	THSD7A	7	11676072	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	207391	11676072	147462591	78	10381											
SAMD9L	219285	broad.mit.edu	37	chr7	92764127	92764127	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctccttcttcattgccttCattccatactcttcttcagc	5	18	2	16	0	7	0	3	0	4	0	9	0	8	0	3	0	3	0	3	0	1	8			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:92764127C>A	uc003umh.1	-	5	2374	c.1158G>T	c.(1156-1158)ATG>ATT	p.M386I	SAMD9L_uc003umj.1_Missense_Mutation_p.M386I|SAMD9L_uc003umi.1_Missense_Mutation_p.M386I|SAMD9L_uc010lfb.1_Missense_Mutation_p.M386I|SAMD9L_uc003umk.1_Missense_Mutation_p.M386I|SAMD9L_uc010lfc.1_Missense_Mutation_p.M386I|SAMD9L_uc010lfd.1_Missense_Mutation_p.M386I|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	386										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TCATTGCCTTCATTCCATACT	0.393													34	349					2.85442e-18	3.34482e-18	1	0	A	92764127	A	A	92764127	3	1	52	1	0	0	0	0	1	0	0	0	13892	826	29	2	3600	2	SAMD9L	7	92764127	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	81088055	92764127	66374536	79	10382											
SAMD9L	219285	broad.mit.edu	37	chr7	92764780	92764780	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggctgtcatggaactgatCaaaaggatatggcatacaag	15	9	11	6	0	2	1	2	1	0	0	2	3	2	3	0	4	2	2	0	4	6	2	rs144605831	byFrequency	TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:92764780C>G	uc003umh.1	-	5	1721	c.505G>C	c.(505-507)GAT>CAT	p.D169H	SAMD9L_uc003umj.1_Missense_Mutation_p.D169H|SAMD9L_uc003umi.1_Missense_Mutation_p.D169H|SAMD9L_uc010lfb.1_Missense_Mutation_p.D169H|SAMD9L_uc003umk.1_Missense_Mutation_p.D169H|SAMD9L_uc010lfc.1_Missense_Mutation_p.D169H|SAMD9L_uc010lfd.1_Missense_Mutation_p.D169H|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	169										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGGAACTGATCAAAAGGATAT	0.363													18	231					0	0	0	0	G	92764780	G	G	92764780	3	3	52	1	0	0	0	0	1	0	0	0	13892	826	29	2	4253	2	SAMD9L	7	92764780	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	653	92764780	66373883	80	10383											
PLOD3	8985	broad.mit.edu	37	chr7	100859263	100859263	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atccttgtacttccactggcGcacgatttggtggatggtgg	6	13	13	9	2	0	0	0	0	0	0	2	2	2	1	2	5	1	2	2	5	1	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:100859263G>A	uc003uyd.2	-	5	997	c.541C>T	c.(541-543)CGC>TGC	p.R181C	ZNHIT1_uc003uye.2_5'Flank|ZNHIT1_uc003uyf.2_5'Flank	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	181					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	TTCCACTGGCGCACGATTTGG	0.617													34	61					0	0	0	0	A	100859263	A	A	100859263	3	1	52	1	0	0	0	0	1	0	0	0	12158	1087	38	1	1735	1	PLOD3	7	100859263	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	8094483	100859263	58279400	81	10384											
FOXP2	93986	broad.mit.edu	37	chr7	114299704	114299704	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacggacatttgcttacttCaggcgtaatgcagcaacttg	11	11	9	10	2	1	0	1	0	0	0	1	1	1	1	0	2	5	4	0	2	3	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:114299704C>G	uc003vhb.2	+	13	1997	c.1623C>G	c.(1621-1623)TTC>TTG	p.F541L	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.F566L|FOXP2_uc003vha.2_Missense_Mutation_p.F449L|FOXP2_uc011kmu.1_Missense_Mutation_p.F558L|FOXP2_uc011kmv.1_Missense_Mutation_p.F540L|FOXP2_uc010ljz.1_Missense_Mutation_p.F356L|FOXP2_uc003vhe.1_Missense_Mutation_p.F111L	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	541	Fork-head.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TTGCTTACTTCAGGCGTAATG	0.323													4	127					0	0	0	0	G	114299704	G	G	114299704	3	3	52	1	0	0	0	0	1	0	0	0	6061	825	29	2	1836	2	FOXP2	7	114299704	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	13440441	114299704	44838959	82	10385											
PTPRZ1	5803	broad.mit.edu	37	chr7	121653325	121653325	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagtcatagtgccaaatctGatgccggtttagtgggtggt	8	13	14	6	1	2	2	1	2	1	0	2	2	2	2	2	3	2	1	2	3	3	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:121653325G>T	uc003vjy.2	+	12	4620	c.4225G>T	c.(4225-4227)GAT>TAT	p.D1409Y	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1409	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TGCCAAATCTGATGCCGGTTT	0.338													68	89					1.84395e-34	2.2295e-34	1	0	T	121653325	T	T	121653325	3	4	52	1	0	0	0	0	1	0	0	0	12879	1290	45	2	4271	2	PTPRZ1	7	121653325	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	7353621	121653325	37485338	83	10386											
CPA2	1358	broad.mit.edu	37	chr7	129929571	129929571	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggcaatcatggagcatgtgcGagaccacccctattagggcc	10	7	12	12	1	1	1	1	0	0	1	1	3	1	2	4	3	2	2	4	3	3	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:129929571G>C	uc003vpq.2	+	11	1263	c.1244G>C	c.(1243-1245)CGA>CCA	p.R415P		NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	415					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					GAGCATGTGCGAGACCACCCC	0.517													33	85					0	0	0	0	C	129929571	C	C	129929571	3	2	52	1	0	0	0	0	1	0	0	0	3805	1058	37	3	1286	3	CPA2	7	129929571	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	8276246	129929571	29209092	84	10387											
TRIM24	8805	broad.mit.edu	37	chr7	138210029	138210029	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagaatcagaaagtgatcAtagatacactaatcaccaaa	19	9	5	8	0	4	4	4	1	0	3	4	4	4	4	1	0	1	0	1	0	6	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:138210029A>G	uc003vuc.2	+	5	1023	c.808A>G	c.(808-810)ATA>GTA	p.I270V	TRIM24_uc003vub.2_Missense_Mutation_p.I270V	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	270					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						GAAAGTGATCATAGATACACT	0.269													11	33					0	0	0	0	G	138210029	G	G	138210029	3	3	52	1	0	0	0	0	1	0	0	0	16565	217	8	5	826	5	TRIM24	7	138210029	Missense_Mutation	SNP	A	TCGA-CN-4741-01A-01D-1434-08	8280458	138210029	20928634	85	10388											
KIAA1549	57670	broad.mit.edu	37	chr7	138545904	138545904	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgcagggattgttggccGtctgggctgggctgtagaag	6	10	17	8	1	1	1	0	0	1	1	1	2	1	2	1	4	1	5	1	4	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:138545904G>A	uc011kql.1	-	16	5277	c.5228C>T	c.(5227-5229)ACG>ATG	p.T1743M	KIAA1549_uc011kqi.1_Missense_Mutation_p.T527M|KIAA1549_uc003vuk.3_Missense_Mutation_p.T1693M|KIAA1549_uc011kqj.1_Missense_Mutation_p.T1743M|KIAA1549_uc011kqk.1_Missense_Mutation_p.T527M	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1743						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						ATTGTTGGCCGTCTGGGCTGG	0.602			O	BRAF	pilocytic astrocytoma								44	54					0	0	0	0	A	138545904	A	A	138545904	3	1	52	1	0	0	0	0	1	0	0	0	8283	1145	40	1	644	1	KIAA1549	7	138545904	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	335875	138545904	20592759	86	10389											
C8orf41	80185	broad.mit.edu	37	chr8	33371071	33371071	+	5'Flank	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccacccttgaaccttgttacGacgtgggcacattacccgtc	8	10	8	15	3	0	1	0	1	0	0	1	2	0	1	4	1	3	2	4	1	3	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:33371071G>C	uc003xjl.3	-						C8orf41_uc003xjk.3_5'Flank|C8orf41_uc010lvv.2_5'Flank|C8orf41_uc003xjm.3_5'Flank|C8orf41_uc003xjn.1_5'Flank	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185								binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		accttgttacgacgtgggcac	0.169													3	175					0	0	0	0	C	33371071	C	C	33371071	1	2	52	0	1	0	0	0	0	0	0	0	2439	1073	37	3		3	C8orf41	8	33371071	5'Flank	SNP	G	TCGA-CN-4741-01A-01D-1434-08		33371071	112992951	87	10390											
RAB11FIP1	80223	broad.mit.edu	37	chr8	37729045	37729045	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggctgggtacaggattgTccagggatgtgccaggaggc	8	7	19	7	0	0	0	0	0	0	0	1	3	1	3	2	7	2	2	2	7	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:37729045T>A	uc003xkm.1	-	4	3319	c.3275A>T	c.(3274-3276)GAC>GTC	p.D1092V	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.D421V|RAB11FIP1_uc003xko.1_Missense_Mutation_p.D421V|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	1092					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TACAGGATTGTCCAGGGATGT	0.557											OREG0018713	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	167	259					0	0	0	0	A	37729045	A	A	37729045	3	1	52	1	0	0	0	0	1	0	0	0	12958	1667	58	5	588	5	RAB11FIP1	8	37729045	Missense_Mutation	SNP	T	TCGA-CN-4741-01A-01D-1434-08	4357974	37729045	108634977	88	10391											
RAB11FIP1	80223	broad.mit.edu	37	chr8	37730417	37730417	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaactctcagtttgcaactCtgccttagggagcaagggtg	10	11	11	9	0	2	0	1	0	2	0	3	1	2	1	1	2	5	3	1	2	5	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:37730417C>T	uc003xkm.1	-	4	1947	c.1903G>A	c.(1903-1905)GAG>AAG	p.E635K	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_5'UTR|RAB11FIP1_uc003xko.1_5'UTR|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	635					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			GTTTGCAACTCTGCCTTAGGG	0.502													24	219					0	0	0	0	T	37730417	T	T	37730417	3	4	52	1	0	0	0	0	1	0	0	0	12958	922	32	2	1960	2	RAB11FIP1	8	37730417	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	1372	37730417	108633605	89	10392											
CHRNB3	1142	broad.mit.edu	37	chr8	42587115	42587115	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cggcgtgtactcctatccctTtatcacgtattccttcgtcc	5	15	6	15	4	1	0	1	0	0	0	6	0	5	0	4	1	1	2	4	1	4	7			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:42587115T>C	uc003xpi.1	+	5	793	c.665T>C	c.(664-666)TTT>TCT	p.F222S		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	222	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TCCTATCCCTTTATCACGTAT	0.478													61	61					0	0	0	0	C	42587115	C	C	42587115	3	2	52	1	0	0	0	0	1	0	0	0	3407	1841	64	5	683	5	CHRNB3	8	42587115	Missense_Mutation	SNP	T	TCGA-CN-4741-01A-01D-1434-08	4856698	42587115	103776907	90	10393											
CA2	760	broad.mit.edu	37	chr8	86389459	86389459	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcctcttctggaatgtgtGacctggattgtgctcaagga	7	13	11	10	0	3	1	1	1	2	0	4	4	4	4	3	3	1	1	3	3	2	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:86389459G>A	uc003ydk.2	+	6	798	c.618G>A	c.(616-618)GTG>GTA	p.V206V		NM_000067	NP_000058	P00918	CAH2_HUMAN	carbonic anhydrase II	206					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(1)	1					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TGGAATGTGTGACCTGGATTG	0.512													9	430					0	0	0	0	A	86389459	A	A	86389459	2	1	52	1	0	0	0	0	0	0	0	1	2528	1277	45	2		2	CA2	8	86389459	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	43802344	86389459	59974563	91	10394											
RGS22	26166	broad.mit.edu	37	chr8	101065137	101065137	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttttgcttgacggaggtGccagaatttcagttcagcac	8	13	12	8	1	2	2	2	1	0	1	2	3	2	3	1	3	3	4	1	3	1	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:101065137G>A	uc003yjb.1	-	10	1777	c.1582C>T	c.(1582-1584)CAC>TAC	p.H528Y	RGS22_uc003yja.1_Missense_Mutation_p.H347Y|RGS22_uc003yjc.1_Missense_Mutation_p.H516Y|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	528					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGACGGAGGTGCCAGAATTTC	0.408													119	188					0	0	0	0	A	101065137	A	A	101065137	3	1	52	1	0	0	0	0	1	0	0	0	13370	1319	46	4	2284	4	RGS22	8	101065137	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	14675678	101065137	45298885	92	10395											
RIMS2	9699	broad.mit.edu	37	chr8	104898340	104898340	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcataaatcaaagaaaggcGgtaaaatgcgccagatttcg	16	8	9	8	3	2	2	2	0	0	2	3	2	2	2	1	2	1	1	1	2	6	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:104898340G>A	uc003yls.2	+	2	1088	c.847G>A	c.(847-849)GGT>AGT	p.G283S	RIMS2_uc003ylp.2_Missense_Mutation_p.G505S|RIMS2_uc003ylw.2_Missense_Mutation_p.G313S|RIMS2_uc003ylq.2_Missense_Mutation_p.G313S|RIMS2_uc003ylr.2_Missense_Mutation_p.G313S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	536					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAAGAAAGGCGGTAAAATGCG	0.428										HNSCC(12;0.0054)			34	49					0	0	0	0	A	104898340	A	A	104898340	3	1	52	1	0	0	0	0	1	0	0	0	13433	1116	39	1	1653	1	RIMS2	8	104898340	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	3833203	104898340	41465682	93	10396											
LRP12	29967	broad.mit.edu	37	chr8	105510194	105510194	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttggcacagatctcttcatCggaactatctccacattcat	10	14	5	12	1	4	1	2	0	2	1	7	2	4	2	1	2	1	1	1	2	2	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:105510194C>T	uc003yma.2	-	5	681	c.586G>A	c.(586-588)GAT>AAT	p.D196N	LRP12_uc003ymb.2_Missense_Mutation_p.D177N|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	196	Extracellular (Potential).|LDL-receptor class A 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATCTCTTCATCGGAACTATCT	0.423													4	210					0	0	0	0	T	105510194	T	T	105510194	3	4	52	1	0	0	0	0	1	0	0	0	9004	884	31	1	2005	1	LRP12	8	105510194	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	611854	105510194	40853828	94	10397											
POU5F1B	5462	broad.mit.edu	37	chr8	128428272	128428272	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgggccgggggttgggccagGctctgaggtgtgggggattc	3	8	22	8	2	1	1	0	1	1	0	2	2	1	2	2	8	0	2	2	8	0	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:128428272G>A	uc003ysf.2	+	1	416	c.161G>A	c.(160-162)GGC>GAC	p.G54D	uc003ysc.1_Intron|uc003ysd.1_Intron|LOC727677_uc003yse.1_Intron|uc011liu.1_RNA	NM_001159542	NP_001153014	Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	54						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTTGGGCCAGGCTCTGAGGTG	0.677													9	8					0	0	0	0	A	128428272	A	A	128428272	3	1	52	1	0	0	0	0	1	0	0	0	12337	1203	42	4	163	4	POU5F1B	8	128428272	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	22918078	128428272	17935750	95	10398											
ZNF16	7564	broad.mit.edu	37	chr8	146157609	146157609	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccacactgtgctggaaactCtggccacccatgtcatatgg	9	10	9	13	0	2	0	1	0	1	0	3	1	3	1	3	3	2	1	3	3	2	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:146157609C>G	uc003zet.2	-	4	751	c.564G>C	c.(562-564)CAG>CAC	p.Q188H	ZNF16_uc003zeu.2_Missense_Mutation_p.Q188H	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		GCTGGAAACTCTGGCCACCCA	0.493													28	260					0	0	0	0	G	146157609	G	G	146157609	3	3	52	1	0	0	0	0	1	0	0	0	17805	912	32	2	1488	2	ZNF16	8	146157609	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	17729337	146157609	206413	96	10399											
AGTPBP1	23287	broad.mit.edu	37	chr9	88162058	88162058	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttgataattcagagtcaGaaagtacttcttcttgagca	12	15	7	7	0	5	4	2	2	3	2	5	4	5	4	0	0	2	2	0	0	3	8			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:88162058G>A	uc011ltd.1	-	25	3680	c.3647C>T	c.(3646-3648)TCT>TTT	p.S1216F	AGTPBP1_uc004aod.3_Missense_Mutation_p.S842F|AGTPBP1_uc011ltc.1_3'UTR|AGTPBP1_uc010mqc.2_Missense_Mutation_p.S1176F|AGTPBP1_uc011lte.1_Missense_Mutation_p.S1228F	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1216					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						TTCAGAGTCAGAAAGTACTTC	0.363													8	152					0	0	0	0	A	88162058	A	A	88162058	3	1	52	1	0	0	0	0	1	0	0	0	400	942	33	2	37	2	AGTPBP1	9	88162058	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08		88162058	53051373	97	10400											
ZNF883	169834	broad.mit.edu	37	chr9	115760138	115760138	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaagggcagagatatggctGaaagctttcccacattcatt	12	11	10	8	0	1	2	1	1	0	1	2	3	2	2	1	2	1	4	1	2	3	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:115760138G>A	uc011lwy.1	-	5	1641	c.402C>T	c.(400-402)TTC>TTT	p.F134F		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	134	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGATATGGCTGAAAGCTTTCC	0.393													6	115					0	0	0	0	A	115760138	A	A	115760138	2	1	52	1	0	0	0	0	0	0	0	1	18265	1281	45	2		2	ZNF883	9	115760138	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	27598080	115760138	25453293	98	10401											
PAPPA	5069	broad.mit.edu	37	chr9	118949729	118949729	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgacccagaagtgcaaagtgCtcatgttagggggcagtgcc	10	8	14	9	0	1	2	1	1	0	1	1	2	1	2	2	2	3	4	2	2	3	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:118949729C>G	uc004bjn.2	+	2	1093	c.712C>G	c.(712-714)CTC>GTC	p.L238V	PAPPA_uc011lxp.1_Missense_Mutation_p.L31V|PAPPA_uc011lxq.1_Missense_Mutation_p.L31V	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	238					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GTGCAAAGTGCTCATGTTAGG	0.557													19	155					0	0	0	0	G	118949729	G	G	118949729	3	3	52	1	0	0	0	0	1	0	0	0	11486	797	28	4	718	4	PAPPA	9	118949729	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	3189591	118949729	22263702	99	10402											
CEP110	11064	broad.mit.edu	37	chr9	123880662	123880662	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaccttctttacaagcagttGagtggtagactacaacttgt	11	13	9	8	0	1	2	0	1	1	1	1	3	1	2	1	1	4	3	1	1	5	7			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:123880662G>C	uc004bkx.1	+	10	1525	c.1494G>C	c.(1492-1494)TTG>TTC	p.L498F	CEP110_uc004bky.1_Missense_Mutation_p.L102F	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	498	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						ACAAGCAGTTGAGTGGTAGAC	0.393													5	342					0	0	0	0	C	123880662	C	C	123880662	3	2	52	1	0	0	0	0	1	0	0	0	3260	1281	45	2	1532	2	CEP110	9	123880662	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	4930933	123880662	17332769	100	10403											
SPTAN1	6709	broad.mit.edu	37	chr9	131370227	131370227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acggacactatgccagccctGagatcaagcagaaacttgat	14	7	9	11	1	1	3	1	2	0	2	1	5	1	4	2	1	4	1	2	1	3	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:131370227G>A	uc004bvl.3	+	33	4356	c.4243G>A	c.(4243-4245)GAG>AAG	p.E1415K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1415K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1395K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1415	Spectrin 15.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGCCAGCCCTGAGATCAAGCA	0.547													7	158					0	0	0	0	A	131370227	A	A	131370227	3	1	52	1	0	0	0	0	1	0	0	0	15183	1291	45	2	4369	2	SPTAN1	9	131370227	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	7489565	131370227	9843204	101	10404											
ZER1	10444	broad.mit.edu	37	chr9	131503106	131503106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcctcagctccttcacttCtgccacattccccaaaagtc	9	10	5	17	0	3	0	2	0	1	0	6	0	5	0	5	1	2	1	5	1	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:131503106C>T	uc004bwa.1	-	12	2231	c.1798G>A	c.(1798-1800)GAA>AAA	p.E600K		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	600	ARM 3.				ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						TCCTTCACTTCTGCCACATTC	0.403													12	192					0	0	0	0	T	131503106	T	T	131503106	3	4	52	1	0	0	0	0	1	0	0	0	17692	922	32	2	522	2	ZER1	9	131503106	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	132879	131503106	9710325	102	10405											
ITIH5	80760	broad.mit.edu	37	chr10	7605143	7605143	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccccgtcaatcagtttggcgGcattgttcctggcaaaccag	8	10	10	13	2	2	0	2	0	0	0	3	0	3	0	4	3	1	4	4	3	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:7605143G>A	uc001ijq.2	-	14	2811	c.2732C>T	c.(2731-2733)GCC>GTC	p.A911V	ITIH5_uc001ijp.2_Missense_Mutation_p.A697V	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	911					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CAGTTTGGCGGCATTGTTCCT	0.522													4	216					0	0	0	0	A	7605143	A	A	7605143	3	1	52	1	0	0	0	0	1	0	0	0	7946	1203	42	4	142	4	ITIH5	10	7605143	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08		7605143	127929604	103	10406											
NRP1	8829	broad.mit.edu	37	chr10	33552574	33552574	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcttcctgtcattcttacCatcagggaatccatcccaga	9	12	7	13	0	3	1	2	0	1	1	6	2	6	2	4	1	2	1	4	1	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:33552574C>T	uc001iwx.3	-	4	1181	c.658G>A	c.(658-660)GTT>ATT	p.V220I	NRP1_uc001iwv.3_Missense_Mutation_p.V220I|NRP1_uc009xlz.2_Missense_Mutation_p.V220I|NRP1_uc001iww.3_Missense_Mutation_p.V39I|NRP1_uc001iwy.3_Missense_Mutation_p.V220I|NRP1_uc001iwz.2_Missense_Mutation_p.V220I|NRP1_uc001ixa.2_Missense_Mutation_p.V220I|NRP1_uc001ixb.1_Missense_Mutation_p.V220I|NRP1_uc001ixc.1_Missense_Mutation_p.V220I	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	220	Extracellular (Potential).|CUB 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	TCATTCTTACCATCAGGGAAT	0.463													9	44					0	0	0	0	T	33552574	T	T	33552574	3	4	52	1	0	0	0	0	1	0	0	0	10714	608	21	4	2180	4	NRP1	10	33552574	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	25947431	33552574	101982173	104	10407											
CCDC109A	90550	broad.mit.edu	37	chr10	74645514	74645514	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctattttaggcagaaatggaCcttaagagactgagagaccc	14	9	10	8	0	0	4	0	1	0	3	0	7	0	5	2	2	0	1	2	2	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:74645514C>T	uc001jtc.2	+	8	1011	c.990C>T	c.(988-990)GAC>GAT	p.D330D	CCDC109A_uc009xqr.2_Silent_p.D309D|CCDC109A_uc001jtd.2_Silent_p.D281D	NM_138357	NP_612366	Q8NE86	MCU_HUMAN	coiled-coil domain containing 109A	330	Potential.|Mitochondrial matrix (Potential).				elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding				0	Prostate(51;0.0198)					CAGAAATGGACCTTAAGAGAC	0.393													20	88					0	0	0	0	T	74645514	T	T	74645514	2	4	52	1	0	0	0	0	0	0	0	1	2756	506	18	4		4	CCDC109A	10	74645514	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	41092940	74645514	60889233	105	10408											
NEURL	9148	broad.mit.edu	37	chr10	105330708	105330708	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtccggcagtgctgcccagCggggggctcccagccacgcc	4	5	15	17	3	0	0	0	0	0	0	2	0	2	0	5	4	4	3	5	4	0	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:105330708C>T	uc001kxh.2	+	2	575	c.165C>T	c.(163-165)AGC>AGT	p.S55S		NM_004210	NP_004201	O76050	NEU1A_HUMAN	neuralized-like	55					nervous system development	perinuclear region of cytoplasm	zinc ion binding				0				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TGCTGCCCAGCGGGGGGCTCC	0.652													68	107					0	0	0	0	T	105330708	T	T	105330708	2	4	52	1	0	0	0	0	0	0	0	1	10399	767	27	1		1	NEURL	10	105330708	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	30685194	105330708	30204039	106	10409											
INPP5F	22876	broad.mit.edu	37	chr10	121586186	121586186	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatcattggtatcaggtctCaaaaccaaggttctttggcc	11	12	8	10	0	4	0	3	0	2	0	5	0	4	0	2	4	1	2	2	4	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:121586186C>G	uc001leo.2	+	20	2459	c.2293C>G	c.(2293-2295)CAA>GAA	p.Q765E	INPP5F_uc001lep.2_Missense_Mutation_p.Q155E	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	765							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		TATCAGGTCTCAAAACCAAGG	0.363													18	254					0	0	0	0	G	121586186	G	G	121586186	3	3	52	1	0	0	0	0	1	0	0	0	7797	827	29	2	2371	2	INPP5F	10	121586186	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	16255478	121586186	13948561	107	10410											
JAKMIP3	282973	broad.mit.edu	37	chr10	133948575	133948575	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgaaaaagatgcccggCgcttccagcttaaaatcgcg	12	8	11	10	4	0	2	0	1	0	1	2	3	1	3	2	2	2	2	2	2	4	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:133948575C>T	uc001lkx.3	+	4	880	c.880C>T	c.(880-882)CGC>TGC	p.R294C		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGATGCCCGGCGCTTCCAGCT	0.502													23	38					0	0	0	0	T	133948575	T	T	133948575	3	4	52	1	0	0	0	0	1	0	0	0	7981	768	27	1	894	1	JAKMIP3	10	133948575	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	12362389	133948575	1586172	108	10411											
AMPD3	272	broad.mit.edu	37	chr11	10516545	10516545	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttgaaaactgaaaactatCtgggaggagagtactttgct	14	12	10	5	0	1	3	0	2	1	1	1	5	1	4	0	2	4	2	0	2	6	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:10516545C>G	uc001mio.1	+	8	1569	c.1234C>G	c.(1234-1236)CTG>GTG	p.L412V	AMPD3_uc010rbz.1_Missense_Mutation_p.L253V|AMPD3_uc001min.1_Missense_Mutation_p.L421V|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.L419V|AMPD3_uc009yfy.2_Missense_Mutation_p.L412V	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	412					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		TGAAAACTATCTGGGAGGAGA	0.537													5	243					0	0	0	0	G	10516545	G	G	10516545	3	3	52	1	0	0	0	0	1	0	0	0	587	912	32	2	1311	2	AMPD3	11	10516545	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08		10516545	124489971	109	10412											
SLC5A12	159963	broad.mit.edu	37	chr11	26747702	26747709	+	5'Flank	DEL	TTCTTCCT	-	-																															tcttttctctccttccttccTtcttccttccttccttcctt																								rs4259786		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:26747702_26747709delTTCTTCCT	uc001mrb.2	-									Q1EHB4	SC5AC_HUMAN	Homo sapiens mRNA; cDNA DKFZp564G223 (from clone DKFZp564G223).						sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						ccttccttccttcttccttccttccttc	0.197													---	---	---								-	26747709	-	-	26747702	6	5	52	0	1	1	0	1	0	0	0	0	14728	1624	56	0		0	SLC5A12	11	26747702	5'Flank	DEL	TTCTTCCT	TCGA-CN-4741-01A-01D-1434-08	16231157	26747702	108258814	110	10413											
CAT	847	broad.mit.edu	37	chr11	34470887	34470887	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgagagagaattcctgagaGagttgtgcatgctaaaggag	13	8	14	6	1	0	4	0	1	0	3	1	8	1	5	2	1	2	3	2	1	3	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:34470887G>C	uc001mvm.2	+	2	298	c.215G>C	c.(214-216)AGA>ACA	p.R72T	CAT_uc009ykc.1_RNA	NM_001752	NP_001743	P04040	CATA_HUMAN	catalase	72					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)	ATTCCTGAGAGAGTTGTGCAT	0.438													13	162					0	0	0	0	C	34470887	C	C	34470887	3	2	52	1	0	0	0	0	1	0	0	0	2698	942	33	2	221	2	CAT	11	34470887	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	7723185	34470887	100535629	111	10414											
RAG1	5896	broad.mit.edu	37	chr11	36596040	36596040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaataaagggggccggcccCgccaacatcttctgtcgctg	8	9	11	13	3	2	0	0	0	2	0	3	0	2	0	4	3	1	1	4	3	4	3	rs104894289		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:36596040C>T	uc001mwu.3	+	2	1310	c.1186C>T	c.(1186-1188)CGC>TGC	p.R396C	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	396	NBD.		R -> C (in OS).|R -> L (in OS).|R -> H (in OS).		histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GGGCCGGCCCCGCCAACATCT	0.483									Familial_Hemophagocytic_Lymphohistiocytosis				32	74					0	0	0	0	T	36596040	T	T	36596040	3	4	52	1	0	0	0	0	1	0	0	0	13068	652	23	1	1188	1	RAG1	11	36596040	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	2125153	36596040	98410476	112	10415											
ANO1	55107	broad.mit.edu	37	chr11	70007338	70007338	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggccgccgccttggccatGaactcctccccctccgtgcg	4	8	10	19	4	0	1	0	1	0	0	3	1	3	1	8	2	2	0	8	2	1	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:70007338G>T	uc001opj.2	+	17	1955	c.1650G>T	c.(1648-1650)ATG>ATT	p.M550I	ANO1_uc001opk.1_Missense_Mutation_p.M492I|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.M259I	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	550	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CCTTGGCCATGAACTCCTCCC	0.582													22	44					8.10497e-08	9.09672e-08	1	0	T	70007338	T	T	70007338	3	4	52	1	0	0	0	0	1	0	0	0	695	1290	45	2	1716	2	ANO1	11	70007338	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	33411298	70007338	64999178	113	10416											
EED	8726	broad.mit.edu	37	chr11	85977185	85977185	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatcattctcttaaacttTggaggatcaattcaaagaga	14	13	8	6	0	4	1	3	0	1	1	5	5	4	4	0	3	1	0	0	3	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:85977185T>C	uc001pbp.2	+	8	1244	c.787T>C	c.(787-789)TGG>CGG	p.W263R	EED_uc010rtm.1_Missense_Mutation_p.W263R|EED_uc001pbq.2_Missense_Mutation_p.W263R|EED_uc001pbr.2_Missense_Mutation_p.W263R|EED_uc001pbs.2_Intron|EED_uc010rtn.1_RNA	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	263	Interaction with EZH2 (By similarity).|WD 4.|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				TCTTAAACTTTGGAGGATCAA	0.294													5	76					0	0	0	0	C	85977185	C	C	85977185	3	2	52	1	0	0	0	0	1	0	0	0	4944	1812	63	5	817	5	EED	11	85977185	Missense_Mutation	SNP	T	TCGA-CN-4741-01A-01D-1434-08	15969847	85977185	49029331	114	10417											
MLL	4297	broad.mit.edu	37	chr11	118375411	118375411	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagctaccatctgatctgtCtgtcttgaccacccggagtc	8	11	9	13	1	4	3	0	2	4	1	5	4	4	4	3	1	2	1	3	1	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:118375411C>G	uc001pta.2	+	27	8818	c.8795C>G	c.(8794-8796)TCT>TGT	p.S2932C	MLL_uc001ptb.2_Missense_Mutation_p.S2935C	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2932					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TCTGATCTGTCTGTCTTGACC	0.498			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								3	108					0	0	0	0	G	118375411	G	G	118375411	3	3	52	1	0	0	0	0	1	0	0	0	9673	913	32	2	8901	2	MLL	11	118375411	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	32398226	118375411	16631105	115	10418			1	16		3	3	737	C		1.159371e-05
MLL	4297	broad.mit.edu	37	chr11	118376025	118376025	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cccttaccacaggactaaatCcaagcttgccaacttctcaa	13	9	4	15	0	1	0	1	0	1	0	3	1	2	1	4	1	4	1	4	1	6	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:118376025C>G	uc001pta.2	+	27	9432	c.9409C>G	c.(9409-9411)CCA>GCA	p.P3137A	MLL_uc001ptb.2_Missense_Mutation_p.P3140A	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3137					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AGGACTAAATCCAAGCTTGCC	0.468			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								7	168					0	0	0	0	G	118376025	G	G	118376025	3	3	52	1	0	0	0	0	1	0	0	0	9673	855	30	2	9515	2	MLL	11	118376025	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	614	118376025	16630491	116	10419			1	16		3	3	737	C		1.159371e-05
MLL	4297	broad.mit.edu	37	chr11	118376147	118376147	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtagtttcccaccaaacatCagcaatcctccttcaggcct	11	10	5	15	0	2	0	2	0	0	0	5	0	5	0	5	1	2	3	5	1	3	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:118376147C>T	uc001pta.2	+	27	9554	c.9531C>T	c.(9529-9531)ATC>ATT	p.I3177I	MLL_uc001ptb.2_Silent_p.I3180I	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3177					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CACCAAACATCAGCAATCCTC	0.502			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								4	128					0	0	0	0	T	118376147	T	T	118376147	2	4	52	1	0	0	0	0	0	0	0	1	9673	816	29	2		2	MLL	11	118376147	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	122	118376147	16630369	117	10420			1	16		3	3	737	C		1.159371e-05
COPS7A	50813	broad.mit.edu	37	chr12	6833912	6833912	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggcagcgctggccacactCatccatcaggtgctggaggc	7	6	15	13	1	2	0	2	0	0	0	3	1	3	1	2	6	2	3	2	6	0	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:6833912C>T	uc001qqj.2	+	2	329	c.90C>T	c.(88-90)CTC>CTT	p.L30L	COPS7A_uc009zex.2_RNA|COPS7A_uc001qqk.2_Silent_p.L30L|COPS7A_uc001qql.2_RNA|COPS7A_uc001qqh.2_Silent_p.L30L|COPS7A_uc001qqi.2_Silent_p.L30L|COPS7A_uc001qqm.2_RNA|COPS7A_uc001qqn.3_Silent_p.L30L|COPS7A_uc001qqo.2_Silent_p.L30L	NM_001164094	NP_001157566	Q9UBW8	CSN7A_HUMAN	COP9 complex subunit 7a	30					cullin deneddylation	cytoplasm|signalosome				ovary(1)	1						TGGCCACACTCATCCATCAGG	0.572													6	99					0	0	0	0	T	6833912	T	T	6833912	2	4	52	1	0	0	0	0	0	0	0	1	3753	813	29	2		2	COPS7A	12	6833912	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08		6833912	127017983	118	10421											
KIAA1467	57613	broad.mit.edu	37	chr12	13224219	13224219	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggctccattgtttggagttaCcgtgctccgtgtcacatgaa	7	13	11	10	2	1	1	1	1	0	0	3	2	3	2	3	2	2	4	3	2	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:13224219C>T	uc001rbi.2	+	10	1436	c.1413C>T	c.(1411-1413)TAC>TAT	p.Y471Y	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	471						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TTTGGAGTTACCGTGCTCCGT	0.512													6	132					0	0	0	0	T	13224219	T	T	13224219	2	4	52	1	0	0	0	0	0	0	0	1	8274	518	18	4		4	KIAA1467	12	13224219	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	6390307	13224219	120627676	119	10422											
SYT10	341359	broad.mit.edu	37	chr12	33560277	33560277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgcctcggcaggtgtcttCggaaggaactgtggctgaac	7	11	14	9	2	1	1	0	1	1	0	3	3	1	3	1	5	3	2	1	5	3	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:33560277C>T	uc001rll.1	-	3	821	c.524G>A	c.(523-525)CGA>CAA	p.R175Q	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	175	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CAGGTGTCTTCGGAAGGAACT	0.438													5	166					0	0	0	0	T	33560277	T	T	33560277	3	4	52	1	0	0	0	0	1	0	0	0	15532	884	31	1	1067	1	SYT10	12	33560277	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	20336058	33560277	100291618	120	10423											
ALG10	84920	broad.mit.edu	37	chr12	34179707	34179707	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccttatgtcatttataggCttaacatacctctgcctccc	9	15	4	13	0	2	0	1	0	1	0	3	0	3	0	4	1	4	1	4	1	6	7			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:34179707C>G	uc001rlm.2	+	3	1598	c.1279C>G	c.(1279-1281)CTT>GTT	p.L427V		NM_032834	NP_116223	Q5BKT4	AG10A_HUMAN	asparagine-linked glycosylation 10 homolog	427	Extracellular (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			skin(1)	1	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				CATTTATAGGCTTAACATACC	0.338													116	201					0	0	0	0	G	34179707	G	G	34179707	3	3	52	1	0	0	0	0	1	0	0	0	511	797	28	4	1289	4	ALG10	12	34179707	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	619430	34179707	99672188	121	10424											
MLL2	8085	broad.mit.edu	37	chr12	49443899	49443899	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcacaggggccagctcctCggggtccaggagcacagggg	7	4	18	12	1	1	0	1	0	0	0	4	1	3	1	3	8	2	2	3	8	0	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:49443899C>A	uc001rta.3	-	11	3472	c.3472G>T	c.(3472-3474)GAG>TAG	p.E1158*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1158	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCCAGCTCCTCGGGGTCCAGG	0.602			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			47	87					2.0833e-19	2.46292e-19	1	0	A	49443899	A	A	49443899	4	1	52	1	0	0	0	0	0	1	0	0	9674	893	31	3	13317	3	MLL2	12	49443899	Nonsense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	15264192	49443899	84407996	122	10425											
TROAP	10024	broad.mit.edu	37	chr12	49719906	49719906	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccttccactcgccccagtttCcaggagctaagaagggagac	10	7	10	14	1	0	2	0	0	0	2	3	4	2	3	5	2	1	2	5	2	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:49719906C>T	uc001rtx.3	+	6	848	c.681C>T	c.(679-681)TTC>TTT	p.F227F	TROAP_uc009zlh.2_Silent_p.F227F|TROAP_uc001rty.2_5'Flank	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	227					cell adhesion	cytoplasm				ovary(1)	1						GCCCCAGTTTCCAGGAGCTAA	0.527													8	243					0	0	0	0	T	49719906	T	T	49719906	2	4	52	1	0	0	0	0	0	0	0	1	16642	854	30	2		2	TROAP	12	49719906	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	276007	49719906	84131989	123	10426											
PAN2	9924	broad.mit.edu	37	chr12	56717884	56717884	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatgaggctcgcacggtctCactgccacagcggcagaggc	8	5	15	13	3	1	2	1	1	1	1	3	3	1	3	1	5	2	3	1	5	0	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:56717884C>T	uc001skx.2	-	13	2387	c.2014G>A	c.(2014-2016)GAG>AAG	p.E672K	PAN2_uc001skw.2_5'UTR|PAN2_uc001skz.2_Missense_Mutation_p.E671K|PAN2_uc001sky.2_Missense_Mutation_p.E672K	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	672					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CGCACGGTCTCACTGCCACAG	0.542													5	135					0	0	0	0	T	56717884	T	T	56717884	3	4	52	1	0	0	0	0	1	0	0	0	11468	835	29	2	1650	2	PAN2	12	56717884	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	6997978	56717884	77134011	124	10427											
XPOT	11260	broad.mit.edu	37	chr12	64818958	64818958	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctttgcaggatatgatgcGaactgtaagtatactggaga	12	12	12	5	1	0	2	0	1	0	1	0	5	0	3	0	2	5	4	0	2	5	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:64818958G>T	uc001ssb.2	+	13	1874	c.1448G>T	c.(1447-1449)CGA>CTA	p.R483L		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	483	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		GATATGATGCGAACTGTAAGT	0.358													7	215					1.76689e-08	1.99997e-08	1	0	T	64818958	T	T	64818958	3	4	52	1	0	0	0	0	1	0	0	0	17518	1058	37	3	1494	3	XPOT	12	64818958	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	8101074	64818958	69032937	125	10428											
GRIP1	23426	broad.mit.edu	37	chr12	66742828	66742828	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	attagtgggttctcgtgtctCcaaattaccaccgtggctag	8	13	10	10	2	2	0	0	0	2	0	4	0	2	0	3	2	1	2	3	2	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:66742828C>T	uc001stk.2	-	24	3443	c.3202G>A	c.(3202-3204)GAG>AAG	p.E1068K	GRIP1_uc001stj.2_Missense_Mutation_p.E835K	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	1120					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		TCTCGTGTCTCCAAATTACCA	0.408													29	332					0	0	0	0	T	66742828	T	T	66742828	3	4	52	1	0	0	0	0	1	0	0	0	6826	864	30	2	32	2	GRIP1	12	66742828	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	1923870	66742828	67109067	126	10429											
ACSS3	79611	broad.mit.edu	37	chr12	81532986	81532986	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtaccacttgtagaagaagCgctaaaaataggacaacaca	18	6	8	9	2	0	2	0	0	0	2	0	3	0	3	1	1	3	3	1	1	9	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:81532986C>A	uc001szl.1	+	4	813	c.722C>A	c.(721-723)GCG>GAG	p.A241E	ACSS3_uc001szm.1_Missense_Mutation_p.A240E	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	241						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GTAGAAGAAGCGCTAAAAATA	0.353													48	69					2.29192e-23	2.73385e-23	1	0	A	81532986	A	A	81532986	3	1	52	1	0	0	0	0	1	0	0	0	190	768	27	3	736	3	ACSS3	12	81532986	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	14790158	81532986	52318909	127	10430											
RASSF9	9182	broad.mit.edu	37	chr12	86199550	86199550	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcctctccacttctctaTgatgcagtaatcactgggct	8	12	9	12	0	3	1	1	1	2	0	5	2	3	2	2	2	2	3	2	2	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:86199550T>C	uc001taf.1	-	2	577	c.238A>G	c.(238-240)ATA>GTA	p.I80V		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	80	Ras-associating.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						CACTTCTCTATGATGCAGTAA	0.488													71	87					0	0	0	0	C	86199550	C	C	86199550	3	2	52	1	0	0	0	0	1	0	0	0	13158	1464	51	5	1073	5	RASSF9	12	86199550	Missense_Mutation	SNP	T	TCGA-CN-4741-01A-01D-1434-08	4666564	86199550	47652345	128	10431											
SPPL3	121665	broad.mit.edu	37	chr12	121206202	121206202	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgggccccaggtggagcttCcgggatagaacgtcaagggg	8	7	17	9	2	1	1	1	0	0	1	2	3	2	3	3	6	2	1	3	6	3	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:121206202C>T	uc001tzd.2	-	8	1180	c.699G>A	c.(697-699)CGG>CGA	p.R233R	SPPL3_uc009zwz.2_Silent_p.R226R|SPPL3_uc001tzc.2_Silent_p.R63R	NM_139015	NP_620584	Q8TCT6	PSL4_HUMAN	signal peptide peptidase 3	234						integral to membrane	aspartic-type endopeptidase activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGTGGAGCTTCCGGGATAGAA	0.542													6	237					0	0	0	0	T	121206202	T	T	121206202	2	4	52	1	0	0	0	0	0	0	0	1	15156	842	30	2		2	SPPL3	12	121206202	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	35006652	121206202	12645693	129	10432											
HSPH1	10808	broad.mit.edu	37	chr13	31712628	31712628	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagcattcatgacattattCatccattccatcacttcatt	11	16	3	11	0	4	2	4	2	0	0	6	2	6	2	2	0	1	1	2	0	1	6			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr13:31712628C>G	uc001utj.2	-	17	2684	c.2286G>C	c.(2284-2286)ATG>ATC	p.M762I	HSPH1_uc001utk.2_Missense_Mutation_p.M718I|HSPH1_uc010aaw.2_Missense_Mutation_p.M721I|HSPH1_uc001utl.2_Missense_Mutation_p.M764I|HSPH1_uc010tds.1_Missense_Mutation_p.M686I	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	762					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TGACATTATTCATCCATTCCA	0.358													6	234					0	0	0	0	G	31712628	G	G	31712628	3	3	52	1	0	0	0	0	1	0	0	0	7470	826	29	2	298	2	HSPH1	13	31712628	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08		31712628	83457250	130	10433											
NBEA	26960	broad.mit.edu	37	chr13	36241642	36241642	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatatactatgaacgagggCgattcagtaatttcagcatt	13	13	8	7	2	3	1	3	1	0	0	3	3	3	1	0	1	3	2	0	1	5	7			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr13:36241642C>T	uc001uvb.2	+	56	8739	c.8533C>T	c.(8533-8535)CGA>TGA	p.R2845*	NBEA_uc010abi.2_Nonsense_Mutation_p.R1503*|NBEA_uc010tef.1_Nonsense_Mutation_p.R638*|NBEA_uc001uvd.2_Nonsense_Mutation_p.R423*	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2845						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGAACGAGGGCGATTCAGTAA	0.428													28	185					0	0	0	0	T	36241642	T	T	36241642	4	4	52	1	0	0	0	0	0	1	0	0	10240	760	27	1	8755	1	NBEA	13	36241642	Nonsense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	4529014	36241642	78928236	131	10434											
SPG20	23111	broad.mit.edu	37	chr13	36909222	36909222	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatccaaaaacctcacaattCgaaggtacccaggatacgaa	17	7	6	11	2	1	0	1	0	0	0	3	3	2	1	3	2	3	1	3	2	8	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr13:36909222C>T	uc001uvn.2	-	3	1016	c.746G>A	c.(745-747)CGA>CAA	p.R249Q	SPG20_uc010ten.1_Missense_Mutation_p.R249Q|SPG20_uc001uvm.2_Missense_Mutation_p.R249Q|SPG20_uc001uvo.2_Missense_Mutation_p.R249Q|SPG20_uc001uvq.2_Missense_Mutation_p.R249Q|SPG20_uc001uvp.2_Missense_Mutation_p.R249Q	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin	249					cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		CCTCACAATTCGAAGGTACCC	0.398													4	164					0	0	0	0	T	36909222	T	T	36909222	3	4	52	1	0	0	0	0	1	0	0	0	15108	884	31	1	1286	1	SPG20	13	36909222	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	667580	36909222	78260656	132	10435											
ELF1	1997	broad.mit.edu	37	chr13	41533074	41533074	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggctcttccacacaggctaGaccggcataactattgagaa	12	8	10	11	1	1	2	0	1	1	2	2	3	2	2	2	3	1	3	2	3	4	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr13:41533074G>C	uc001uxs.2	-	3	524	c.151C>G	c.(151-153)CTA>GTA	p.L51V	ELF1_uc010tfc.1_Missense_Mutation_p.L51V|ELF1_uc010acd.2_5'UTR	NM_172373	NP_758961	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription	51					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		ACACAGGCTAGACCGGCATAA	0.453													42	71					0	0	0	0	C	41533074	C	C	41533074	3	2	52	1	0	0	0	0	1	0	0	0	5077	933	33	2	1736	2	ELF1	13	41533074	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	4623852	41533074	73636804	133	10436											
KIAA0391	9692	broad.mit.edu	37	chr14	35592848	35592848	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacttaaggaagatttaaaaGaaaacaccggaaagaccagt	21	6	8	6	1	0	3	0	0	0	3	0	5	0	5	2	2	2	0	2	2	8	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr14:35592848G>C	uc001wsy.1	+	2	757	c.397G>C	c.(397-399)GAA>CAA	p.E133Q	KIAA0391_uc010tps.1_Missense_Mutation_p.E38Q|KIAA0391_uc001wsz.1_Missense_Mutation_p.E133Q|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Missense_Mutation_p.E133Q|KIAA0391_uc001wtc.1_Intron|PPP2R3C_uc001wss.2_5'Flank|PPP2R3C_uc001wst.2_5'Flank|PPP2R3C_uc010tpr.1_5'Flank|PPP2R3C_uc001wsu.2_5'Flank|PPP2R3C_uc010amn.1_5'Flank|PPP2R3C_uc001wsw.2_5'Flank|PPP2R3C_uc001wsx.1_5'Flank	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	133					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		AGATTTAAAAGAAAACACCGG	0.433													3	102					0	0	0	0	C	35592848	C	C	35592848	3	2	52	1	0	0	0	0	1	0	0	0	8211	943	33	2	399	2	KIAA0391	14	35592848	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08		35592848	71756692	134	10437											
PYGL	5836	broad.mit.edu	37	chr14	51398432	51398432	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgattgaaaatcccatattCataccgaatgccgtatccat	13	12	5	11	2	1	2	1	2	0	0	3	3	3	2	4	0	2	1	4	0	6	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr14:51398432C>T	uc001wyu.2	-	4	614	c.487G>A	c.(487-489)GAA>AAA	p.E163K	PYGL_uc010tqq.1_Missense_Mutation_p.E129K|PYGL_uc001wyv.2_5'UTR|PYGL_uc001wyw.3_Missense_Mutation_p.E163K	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	163					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	ATCCCATATTCATACCGAATG	0.438													4	200					0	0	0	0	T	51398432	T	T	51398432	3	4	52	1	0	0	0	0	1	0	0	0	12926	835	29	2	2124	2	PYGL	14	51398432	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	15805584	51398432	55951108	135	10438											
EIF2S1	1965	broad.mit.edu	37	chr14	67831504	67831504	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgccgggtctaagttgtaGattttatcaacacaaatttc	13	14	7	7	1	2	1	1	0	1	1	3	1	2	1	1	1	2	2	1	1	6	6			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr14:67831504G>C	uc001xjg.2	+	2	161	c.20G>C	c.(19-21)AGA>ACA	p.R7T		NM_004094	NP_004085	P05198	IF2A_HUMAN	eukaryotic translation initiation factor 2,	7						cytosol|eukaryotic translation initiation factor 2 complex|polysome|stress granule	protein binding|ribosome binding|translation initiation factor activity			ovary(1)	1				all cancers(60;0.000683)|OV - Ovarian serous cystadenocarcinoma(108;0.00579)|BRCA - Breast invasive adenocarcinoma(234;0.00937)		ctaagttgtagattttatcaa	0.234													3	151					0	0	0	0	C	67831504	C	C	67831504	3	2	52	1	0	0	0	0	1	0	0	0	5031	942	33	2	22	2	EIF2S1	14	67831504	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	16433072	67831504	39518036	136	10439											
ADAM20	8748	broad.mit.edu	37	chr14	70989722	70989722	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaagtggtgtcattgaggtGaaactgctgcactgtagaat	11	11	13	6	0	1	3	1	2	0	1	1	3	1	3	0	2	3	4	0	2	4	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr14:70989722G>A	uc001xme.2	-	2	2148	c.1903C>T	c.(1903-1905)CAC>TAC	p.H635Y		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	585	Cys-rich.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TCATTGAGGTGAAACTGCTGC	0.443													6	139					0	0	0	0	A	70989722	A	A	70989722	3	1	52	1	0	0	0	0	1	0	0	0	242	1290	45	2	431	2	ADAM20	14	70989722	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	3158218	70989722	36359818	137	10440											
NRXN3	9369	broad.mit.edu	37	chr14	80130147	80130147	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaaaattggagttgtcttCaacattggcacagttgacat	12	12	11	6	0	2	1	1	1	1	0	2	3	2	3	0	3	1	3	0	3	3	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr14:80130147C>A	uc001xun.2	+	14	2843	c.2352C>A	c.(2350-2352)TTC>TTA	p.F784L	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.F152L|NRXN3_uc010asw.2_Missense_Mutation_p.F152L|NRXN3_uc001xur.3_Missense_Mutation_p.F152L	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1157	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GAGTTGTCTTCAACATTGGCA	0.448													21	29					1.28384e-07	1.43488e-07	1	0	A	80130147	A	A	80130147	3	1	52	1	0	0	0	0	1	0	0	0	10721	825	29	2	2649	2	NRXN3	14	80130147	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	9140425	80130147	27219393	138	10441											
UBE3A	7337	broad.mit.edu	37	chr15	25616832	25616832	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttgtttaactttccggaaGctctgtaccaatgcctcagc	8	14	8	11	1	2	0	1	0	1	0	3	1	3	1	3	1	5	4	3	1	4	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:25616832G>T	uc001zaq.2	-	4	498	c.498C>A	c.(496-498)AGC>AGA	p.S166R	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.S143R|UBE3A_uc001zas.2_Missense_Mutation_p.S163R|UBE3A_uc001zat.2_Missense_Mutation_p.S143R	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	166					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		CTTTCCGGAAGCTCTGTACCA	0.363													70	106					7.07328e-35	8.59129e-35	1	0	T	25616832	T	T	25616832	3	4	52	1	0	0	0	0	1	0	0	0	16947	962	34	4	2161	4	UBE3A	15	25616832	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08		25616832	76914560	139	10442											
EIF2AK4	440275	broad.mit.edu	37	chr15	40241351	40241351	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actggcttaccacgtgcagtCatttctcagcgagcataaca	11	10	8	12	2	2	0	2	0	1	0	3	1	2	0	1	1	5	3	1	1	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:40241351C>G	uc001zkm.1	+	4	445	c.395C>G	c.(394-396)TCA>TGA	p.S132*	EIF2AK4_uc001zkl.2_Nonsense_Mutation_p.S132*	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	132	RWD.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CACGTGCAGTCATTTCTCAGC	0.478													21	320					0	0	0	0	G	40241351	G	G	40241351	4	3	52	1	0	0	0	0	0	1	0	0	5021	838	29	2	409	2	EIF2AK4	15	40241351	Nonsense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	14624519	40241351	62290041	140	10443											
MEGF11	84465	broad.mit.edu	37	chr15	66190400	66190400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatagctggagttatgacCgcaaccttcttggaccacac	11	10	9	11	1	1	1	0	1	1	0	1	4	1	3	3	2	2	3	3	2	4	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:66190400C>T	uc002apm.2	-	23	3148	c.3007G>A	c.(3007-3009)GGT>AGT	p.G1003S	MEGF11_uc002apl.2_Missense_Mutation_p.G928S	NM_032445	NP_115821	A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11 precursor	1003						basolateral plasma membrane|integral to membrane				pancreas(1)	1						GAGTTATGACCGCAACCTTCT	0.458													29	46					0	0	0	0	T	66190400	T	T	66190400	3	4	52	1	0	0	0	0	1	0	0	0	9514	652	23	1	131	1	MEGF11	15	66190400	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	25949049	66190400	36340992	141	10444											
HCN4	10021	broad.mit.edu	37	chr15	73622066	73622066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcgcctgccgcccgtagcCgatgcacagcatgtggctca	6	6	14	15	4	1	0	1	0	0	0	1	1	1	0	4	2	4	4	4	2	1	1	rs121908411		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:73622066C>T	uc002avp.2	-	4	2432	c.1438G>A	c.(1438-1440)GGC>AGC	p.G480S		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	480					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		CGCCCGTAGCCGATGCACAGC	0.622													34	35					0	0	0	0	T	73622066	T	T	73622066	3	4	52	1	0	0	0	0	1	0	0	0	7038	652	23	1	2193	1	HCN4	15	73622066	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	7431666	73622066	28909326	142	10445											
MAN2C1	4123	broad.mit.edu	37	chr15	75655014	75655014	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagatgaactcagggttcCgctccatgagctgcagggcg	10	7	13	11	2	1	3	1	2	0	1	3	3	3	3	2	2	3	4	2	2	2	1	rs149884810		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:75655014C>T	uc002baf.2	-	7	883	c.866G>A	c.(865-867)CGG>CAG	p.R289Q	MAN2C1_uc002bag.2_Missense_Mutation_p.R289Q|MAN2C1_uc002bah.2_Missense_Mutation_p.R289Q|MAN2C1_uc010bkk.2_Intron|MAN2C1_uc010umi.1_Missense_Mutation_p.R71Q|MAN2C1_uc010umj.1_RNA	NM_006715	NP_006706	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	289					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding				0						CTCAGGGTTCCGCTCCATGAG	0.622													12	54					0	0	0	0	T	75655014	T	T	75655014	3	4	52	1	0	0	0	0	1	0	0	0	9271	652	23	1	2336	1	MAN2C1	15	75655014	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	2032948	75655014	26876378	143	10446											
NRG4	145957	broad.mit.edu	37	chr15	76254257	76254257	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggttacttttagtttggaTgctggagcctgggagaaaaa	11	12	13	5	0	0	1	0	0	0	1	0	4	0	3	1	4	3	3	1	4	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:76254257T>A	uc002bbo.2	-	4	347	c.163A>T	c.(163-165)ATC>TTC	p.I55F	NRG4_uc010bkm.1_RNA|NRG4_uc002bbn.2_RNA|NRG4_uc010bkn.2_RNA|NRG4_uc010bko.2_RNA|NRG4_uc002bbp.2_RNA	NM_138573	NP_612640	Q8WWG1	NRG4_HUMAN	neuregulin 4	55	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	growth factor activity				0						TTAGTTTGGATGCTGGAGCCT	0.388													80	108					0	0	0	0	A	76254257	A	A	76254257	3	1	52	1	0	0	0	0	1	0	0	0	10704	1464	51	5	196	5	NRG4	15	76254257	Missense_Mutation	SNP	T	TCGA-CN-4741-01A-01D-1434-08	599243	76254257	26277135	144	10447											
MAN2A2	4122	broad.mit.edu	37	chr15	91454654	91454654	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccactggaacaggagcgattCagcatggtgtccctgctggt	8	9	13	11	1	1	0	1	0	0	0	2	3	2	2	2	4	4	2	2	4	1	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:91454654C>T	uc010bnz.2	+	14	2098	c.1983C>T	c.(1981-1983)TTC>TTT	p.F661F	MAN2A2_uc002bqc.2_Silent_p.F661F|MAN2A2_uc010uql.1_Silent_p.F323F|MAN2A2_uc010uqm.1_Silent_p.F240F|MAN2A2_uc010uqn.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	661	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			AGGAGCGATTCAGCATGGTGT	0.627													36	102					0	0	0	0	T	91454654	T	T	91454654	2	4	52	1	0	0	0	0	0	0	0	1	9268	825	29	2		2	MAN2A2	15	91454654	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	15200397	91454654	11076738	145	10448											
DNASE1L2	1775	broad.mit.edu	37	chr16	2288404	2288404	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttccagtggaggtgaccctCaagttccaccgatgactcga	9	10	10	12	2	1	2	1	2	0	0	4	5	3	3	4	2	0	1	4	2	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:2288404C>T	uc002cpo.2	+	6	1279	c.885C>T	c.(883-885)CTC>CTT	p.L295L	DNASE1L2_uc002cpn.2_Silent_p.L274L|DNASE1L2_uc002cpp.2_Silent_p.L295L|DNASE1L2_uc002cpq.2_Silent_p.L295L	NM_001374	NP_001365	Q92874	DNSL2_HUMAN	deoxyribonuclease I-like 2 precursor	295					DNA catabolic process	extracellular region	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|protein binding				0						AGGTGACCCTCAAGTTCCACC	0.637													5	153					0	0	0	0	T	2288404	T	T	2288404	2	4	52	1	0	0	0	0	0	0	0	1	4684	813	29	2		2	DNASE1L2	16	2288404	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08		2288404	88066349	146	10449											
ACSM2A	123876	broad.mit.edu	37	chr16	20489931	20489931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggcaacgtcctgccccccGgcacagaaggagacattggc	10	4	13	14	2	0	2	0	0	0	2	1	3	1	2	4	4	2	2	4	4	2	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:20489931G>A	uc010bwe.2	+	11	1452	c.1213G>A	c.(1213-1215)GGC>AGC	p.G405S	ACSM2A_uc010vax.1_Missense_Mutation_p.G326S|ACSM2A_uc002dhf.3_Missense_Mutation_p.G405S|ACSM2A_uc002dhg.3_Missense_Mutation_p.G405S|ACSM2A_uc010vay.1_Missense_Mutation_p.G326S|ACSM2A_uc002dhh.3_Missense_Mutation_p.G35S	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	405					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CCTGCCCCCCGGCACAGAAGG	0.512													30	81					0	0	0	0	A	20489931	A	A	20489931	3	1	52	1	0	0	0	0	1	0	0	0	183	1116	39	1	1247	1	ACSM2A	16	20489931	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	18201527	20489931	69864822	147	10450											
ACSM3	6296	broad.mit.edu	37	chr16	20808211	20808211	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccttgatgccaacaggtaGaatttattcaagagctgcca	12	10	8	11	0	1	3	1	1	0	2	1	3	1	3	4	1	4	2	4	1	5	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:20808211G>C	uc002dhr.2	+	14	1865	c.1678G>C	c.(1678-1680)GAA>CAA	p.E560Q	ERI2_uc002dht.3_3'UTR|ACSM3_uc010vba.1_Missense_Mutation_p.E589Q|ERI2_uc002dhs.2_Intron|ERI2_uc010vbb.1_3'UTR|ERI2_uc010bwh.2_3'UTR|ERI2_uc010vbc.1_3'UTR|ERI2_uc002dhu.1_3'UTR	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	560					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						CCAACAGGTAGAATTTATTCA	0.323													3	91					0	0	0	0	C	20808211	C	C	20808211	3	2	52	1	0	0	0	0	1	0	0	0	185	943	33	2	1821	2	ACSM3	16	20808211	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	318280	20808211	69546542	148	10451											
POLR3E	55718	broad.mit.edu	37	chr16	22344979	22344979	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcataggactgctgtgtaagCtatggtggcatgtggtacct	8	13	13	7	0	1	0	1	0	0	0	1	1	1	1	1	4	3	5	1	4	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:22344979C>T	uc002dkk.2	+	21	2241	c.2085C>T	c.(2083-2085)AGC>AGT	p.S695S	POLR3E_uc002dkm.2_Silent_p.S659S|POLR3E_uc010vbr.1_Silent_p.S674S|POLR3E_uc002dkl.2_Silent_p.S653S|POLR3E_uc010vbs.1_Silent_p.S659S|POLR3E_uc010vbt.1_Silent_p.S639S	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	695					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		GCTGTGTAAGCTATGGTGGCA	0.433													33	58					0	0	0	0	T	22344979	T	T	22344979	2	4	52	1	0	0	0	0	0	0	0	1	12287	796	28	4		4	POLR3E	16	22344979	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	1536768	22344979	68009774	149	10452											
CLN3	1201	broad.mit.edu	37	chr16	28498849	28498849	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagcacaaatcccactgaCgagaacccgggggctgaggg	12	3	14	12	2	0	3	0	2	0	1	1	4	1	3	2	3	3	3	2	3	2	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:28498849C>T	uc002dpo.2	-	6	711	c.388G>A	c.(388-390)GTC>ATC	p.V130I	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.V52I|CLN3_uc010vcu.1_Missense_Mutation_p.V30I|CLN3_uc002dpn.2_Missense_Mutation_p.R103H|CLN3_uc002dpm.2_Missense_Mutation_p.V76I|CLN3_uc010vcv.1_Missense_Mutation_p.V106I|CLN3_uc010byd.2_Missense_Mutation_p.V130I|CLN3_uc002dpp.2_Missense_Mutation_p.V130I|CLN3_uc002dpt.1_Missense_Mutation_p.V30I|CLN3_uc002dpq.1_Missense_Mutation_p.V130I|CLN3_uc010bye.1_Missense_Mutation_p.V130I|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.R75H|CLN3_uc002dpu.1_Missense_Mutation_p.V76I|CLN3_uc002dpw.1_Missense_Mutation_p.R49H|CLN3_uc010vcw.1_Missense_Mutation_p.V76I|CLN3_uc002dqa.2_Missense_Mutation_p.V181I|CLN3_uc010vcx.1_Missense_Mutation_p.V30I|CLN3_uc002dpx.1_Missense_Mutation_p.R79H|CLN3_uc002dpy.1_Missense_Mutation_p.R46H|CLN3_uc002dpz.1_RNA	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	130	Helical; (Potential).				amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						ATCCCACTGACGAGAACCCGG	0.587													18	31					0	0	0	0	T	28498849	T	T	28498849	3	4	52	1	0	0	0	0	1	0	0	0	3558	536	19	1	968	1	CLN3	16	28498849	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	6153870	28498849	61855904	150	10453											
CDH5	1003	broad.mit.edu	37	chr16	66430060	66430060	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	actggacagagaagtctaccCctggtataacctgactgtgg	11	9	11	10	0	1	2	0	1	1	1	1	4	1	3	3	3	2	1	3	3	4	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:66430060C>T	uc002eom.3	+	8	1472	c.1316C>T	c.(1315-1317)CCC>CTC	p.P439L		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	439	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GAAGTCTACCCCTGGTATAAC	0.498													39	78					0	0	0	0	T	66430060	T	T	66430060	3	4	52	1	0	0	0	0	1	0	0	0	3128	623	22	4	1342	4	CDH5	16	66430060	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	37931211	66430060	23924693	151	10454											
NFATC3	4775	broad.mit.edu	37	chr16	68224779	68224779	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctctgattcagggtgttCacatgacagtgtactgtcag	8	14	10	9	0	4	2	3	2	1	0	5	2	5	2	1	1	1	2	1	1	1	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:68224779C>T	uc002evo.1	+	9	2417	c.2207C>T	c.(2206-2208)TCA>TTA	p.S736L	NFATC3_uc010vkl.1_Missense_Mutation_p.S257L|NFATC3_uc010vkm.1_Missense_Mutation_p.S257L|NFATC3_uc010vkn.1_Missense_Mutation_p.S257L|NFATC3_uc010vko.1_Missense_Mutation_p.S257L|NFATC3_uc010vkp.1_Missense_Mutation_p.S257L|NFATC3_uc010vkq.1_Missense_Mutation_p.S257L|NFATC3_uc002evl.2_Missense_Mutation_p.S257L|NFATC3_uc002evk.2_Missense_Mutation_p.S736L|NFATC3_uc002evm.1_Missense_Mutation_p.S736L|NFATC3_uc002evn.1_Missense_Mutation_p.S736L|NFATC3_uc010vkr.1_Missense_Mutation_p.S257L|NFATC3_uc010vks.1_Missense_Mutation_p.S257L|NFATC3_uc010vkt.1_Missense_Mutation_p.S257L|NFATC3_uc010vku.1_Missense_Mutation_p.S257L|NFATC3_uc010vkv.1_Missense_Mutation_p.S257L|NFATC3_uc010vkw.1_Missense_Mutation_p.S257L|NFATC3_uc010vkx.1_Missense_Mutation_p.S257L|NFATC3_uc010vky.1_Missense_Mutation_p.S257L|NFATC3_uc010vkz.1_Missense_Mutation_p.S257L|NFATC3_uc010vla.1_Missense_Mutation_p.S257L|NFATC3_uc010vlb.1_Missense_Mutation_p.S257L|NFATC3_uc010vlc.1_Missense_Mutation_p.S257L	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	736					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TCAGGGTGTTCACATGACAGT	0.478													9	137					0	0	0	0	T	68224779	T	T	68224779	3	4	52	1	0	0	0	0	1	0	0	0	10418	838	29	2	2241	2	NFATC3	16	68224779	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	1794719	68224779	22129974	152	10455											
CHST6	4166	broad.mit.edu	37	chr16	75512968	75512968	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcttgagtgtggcggcctcGgcgatgcgtacgtggctacg	4	9	18	10	6	0	1	0	1	0	0	1	2	0	1	1	5	3	3	1	5	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:75512968G>A	uc002fef.2	-	3	939	c.759C>T	c.(757-759)GCC>GCT	p.A253A	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.A253A	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	253	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						TGGCGGCCTCGGCGATGCGTA	0.716													22	33					0	0	0	0	A	75512968	A	A	75512968	2	1	52	1	0	0	0	0	0	0	0	1	3423	1103	39	1		1	CHST6	16	75512968	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	7288189	75512968	14841785	153	10456											
ADAMTS18	170692	broad.mit.edu	37	chr16	77465305	77465305	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgaagcaccatcttttcCaagtacctggacaataaagt	13	11	6	11	0	2	1	0	1	2	0	3	2	3	2	3	1	2	2	3	1	6	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:77465305C>G	uc002ffc.3	-	3	801	c.382G>C	c.(382-384)GGA>CGA	p.G128R	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	128					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CCATCTTTTCCAAGTACCTGG	0.473													4	205					0	0	0	0	G	77465305	G	G	77465305	3	3	52	1	0	0	0	0	1	0	0	0	263	603	21	4	3367	4	ADAMTS18	16	77465305	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	1952337	77465305	12889448	154	10457											
CLEC3A	10143	broad.mit.edu	37	chr16	78064472	78064472	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatccccaggaactccgacGaaatcaacgccctccaagac	13	6	6	16	3	1	1	1	0	0	1	4	4	4	2	5	1	2	0	5	1	5	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:78064472G>T	uc002ffh.3	+	3	409	c.328G>T	c.(328-330)GAA>TAA	p.E110*		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	110	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						GAACTCCGACGAAATCAACGC	0.478													47	84					8.20599e-20	9.74461e-20	1	0	T	78064472	T	T	78064472	4	4	52	1	0	0	0	0	0	1	0	0	3525	1059	37	3	338	3	CLEC3A	16	78064472	Nonsense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	599167	78064472	12290281	155	10458											
PLD2	5338	broad.mit.edu	37	chr17	4713248	4713248	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcatttgttcagctctttGaccctggctttgaggtgcaa	6	16	9	10	0	3	2	2	2	2	0	4	2	3	2	1	2	2	4	1	2	1	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:4713248G>A	uc002fzc.2	+	9	885	c.784G>A	c.(784-786)GAC>AAC	p.D262N	PLD2_uc010vsj.1_Missense_Mutation_p.D119N|PLD2_uc002fzd.2_Missense_Mutation_p.D262N	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	262	PH.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	TCAGCTCTTTGACCCTGGCTT	0.592													5	148					0	0	0	0	A	4713248	A	A	4713248	3	1	52	1	0	0	0	0	1	0	0	0	12101	1290	45	2	814	2	PLD2	17	4713248	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08		4713248	76481962	156	10459											
NLRP1	22861	broad.mit.edu	37	chr17	5418344	5418344	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctatcagctgctctcgataCtggtccacaaagtgcagcaa	11	9	9	12	1	2	0	1	0	1	0	4	1	3	0	1	1	5	5	1	1	4	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:5418344C>A	uc002gci.2	-	17	4707	c.4152G>T	c.(4150-4152)CAG>CAT	p.Q1384H	NLRP1_uc002gcg.1_Intron|NLRP1_uc002gck.2_Missense_Mutation_p.Q1340H|NLRP1_uc002gcj.2_Missense_Mutation_p.Q1354H|NLRP1_uc002gcl.2_Missense_Mutation_p.Q1310H|NLRP1_uc002gch.3_Missense_Mutation_p.Q1340H	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	1384	CARD.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GCTCTCGATACTGGTCCACAA	0.582													21	37					8.10497e-08	9.09672e-08	1	0	A	5418344	A	A	5418344	3	1	52	1	0	0	0	0	1	0	0	0	10525	564	20	4	336	4	NLRP1	17	5418344	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	705096	5418344	75776866	157	10460											
C17orf75	64149	broad.mit.edu	37	chr17	30668260	30668260	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagtttctgcatttgtgcCacttgggcttccgtcctcac	4	14	11	12	1	2	0	1	0	1	0	4	1	4	1	3	2	2	3	3	2	0	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:30668260C>T	uc002hhg.2	-	2	215	c.184G>A	c.(184-186)GGC>AGC	p.G62S		NM_022344	NP_071739	Q9HAS0	NJMU_HUMAN	hypothetical protein LOC64149	62					spermatogenesis					ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			GCATTTGTGCCACTTGGGCTT	0.463													8	241					0	0	0	0	T	30668260	T	T	30668260	3	4	52	1	0	0	0	0	1	0	0	0	1888	594	21	4	1042	4	C17orf75	17	30668260	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	25249916	30668260	50526950	158	10461											
RFFL	117584	broad.mit.edu	37	chr17	33343399	33343399	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agcccctcacccaggtgctgGagtcctttctgatccttgta	6	12	9	14	0	2	1	1	1	1	0	4	2	4	2	5	2	2	2	5	2	1	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:33343399G>C	uc002hin.1	-	5	1049	c.876C>G	c.(874-876)CTC>CTG	p.L292L	RFFL_uc002hiq.2_Silent_p.L209L|RFFL_uc002him.1_Silent_p.L292L|RFFL_uc010cti.1_Silent_p.L298L|RFFL_uc002hip.1_Silent_p.L264L|RFFL_uc002hio.1_Silent_p.L292L	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	292					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CCAGGTGCTGGAGTCCTTTCT	0.502													3	209					0	0	0	0	C	33343399	C	C	33343399	2	2	52	1	0	0	0	0	0	0	0	1	13315	1161	41	2		2	RFFL	17	33343399	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	2675139	33343399	47851811	159	10462											
RASL10B	91608	broad.mit.edu	37	chr17	34068186	34068186	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagtgcggctacgtggaatgCtcggccaagtacaactggca	11	7	13	10	3	0	0	0	0	0	0	1	1	0	1	1	4	5	4	1	4	6	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:34068186C>T	uc002hju.2	+	4	840	c.474C>T	c.(472-474)TGC>TGT	p.C158C		NM_033315	NP_201572	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B precursor	158	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			lung(2)|breast(2)	4				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACGTGGAATGCTCGGCCAAGT	0.647													22	45					0	0	0	0	T	34068186	T	T	34068186	2	4	52	1	0	0	0	0	0	0	0	1	13145	805	28	4		4	RASL10B	17	34068186	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	724787	34068186	47127024	160	10463											
NSF	4905	broad.mit.edu	37	chr17	44770362	44770362	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggctggtagcacgggagttCatgacactgttgtcaaccag	9	10	13	9	1	2	1	2	1	0	0	2	2	2	2	1	3	2	5	1	3	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:44770362C>G	uc002iku.2	+	10	1143	c.1039C>G	c.(1039-1041)CAT>GAT	p.H347D	NSF_uc010wke.1_Missense_Mutation_p.H253D|NSF_uc010wkf.1_Missense_Mutation_p.H253D|NSF_uc010wkg.1_Missense_Mutation_p.H342D	NM_006178	NP_006169	P46459	NSF_HUMAN	vesicle-fusing ATPase	347					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			ovary(1)	1		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		CACGGGAGTTCATGACACTGT	0.423													3	106					0	0	0	0	G	44770362	G	G	44770362	3	3	52	1	0	0	0	0	1	0	0	0	10725	826	29	2	1077	2	NSF	17	44770362	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	10702176	44770362	36424848	161	10464											
TRIM37	4591	broad.mit.edu	37	chr17	57165711	57165711	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agttgaagagtatcaagctgTtgtgttacttcttctgccca	9	15	9	8	0	3	2	1	1	2	1	3	2	3	2	1	0	3	5	1	0	4	6			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:57165711T>C	uc002iwy.3	-	4	666	c.222A>G	c.(220-222)CAA>CAG	p.Q74Q	TRIM37_uc002iwz.3_Silent_p.Q74Q|TRIM37_uc002ixa.3_5'UTR|TRIM37_uc010woc.1_Silent_p.Q40Q	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	74						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TATCAAGCTGTTGTGTTACTT	0.383									Mulibrey_Nanism				22	29					0	0	0	0	C	57165711	C	C	57165711	2	2	52	1	0	0	0	0	0	0	0	1	16578	1722	60	5		5	TRIM37	17	57165711	Silent	SNP	T	TCGA-CN-4741-01A-01D-1434-08	12395349	57165711	24029499	162	10465											
GNA13	10672	broad.mit.edu	37	chr17	63010430	63010430	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatagtatccttcacgtcaCggaaaacaaggcggatgttc	13	9	10	9	3	2	0	2	0	0	0	4	3	3	2	1	3	1	2	1	3	6	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:63010430C>A	uc002jfc.2	-	4	1288	c.1079G>T	c.(1078-1080)CGT>CTT	p.R360L	GNA13_uc010wqh.1_Missense_Mutation_p.R265L	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	360					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						CTTCACGTCACGGAAAACAAG	0.443													3	97					0.004672	0.00499097	1	0	A	63010430	A	A	63010430	3	1	52	1	0	0	0	0	1	0	0	0	6538	536	19	3	58	3	GNA13	17	63010430	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	5844719	63010430	18184780	163	10466											
SSTR2	6752	broad.mit.edu	37	chr17	71166310	71166310	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttccgtctccatggccatCagccccaccccagcccttaa	7	9	5	20	1	3	0	1	0	2	0	5	0	4	0	8	1	2	0	8	1	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:71166310C>T	uc002jje.2	+	2	1212	c.852C>T	c.(850-852)ATC>ATT	p.I284I		NM_001050	NP_001041	P30874	SSR2_HUMAN	somatostatin receptor 2	284	Extracellular (Potential).				digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity				0			LUSC - Lung squamous cell carcinoma(166;0.197)			CCATGGCCATCAGCCCCACCC	0.507													5	199					0	0	0	0	T	71166310	T	T	71166310	2	4	52	1	0	0	0	0	0	0	0	1	15264	816	29	2		2	SSTR2	17	71166310	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	8155880	71166310	10028900	164	10467											
CDR2L	30850	broad.mit.edu	37	chr17	72999894	72999894	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagctgctgagcaagtgcCggcagcacggggccggagtg	8	4	19	10	3	0	1	0	1	0	0	0	3	0	3	2	5	5	5	2	5	1	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:72999894C>T	uc002jml.3	+	5	1535	c.1123C>T	c.(1123-1125)CGG>TGG	p.R375W		NM_014603	NP_055418	Q86X02	CDR2L_HUMAN	cerebellar degeneration-related protein 2-like	375	Potential.										0	all_lung(278;0.226)					GAGCAAGTGCCGGCAGCACGG	0.711													3	0					0	0	0	0	T	72999894	T	T	72999894	3	4	52	1	0	0	0	0	1	0	0	0	3188	643	23	1	1141	1	CDR2L	17	72999894	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	1833584	72999894	8195316	165	10468											
NOL4	8715	broad.mit.edu	37	chr18	31538327	31538327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgagaggtcctcagctcctCggtctacactctcatttttg	6	14	9	12	1	3	1	2	1	2	1	7	2	5	1	2	2	2	1	2	2	1	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:31538327C>T	uc010dmi.2	-	7	1341	c.1112G>A	c.(1111-1113)CGA>CAA	p.R371Q	NOL4_uc010xbs.1_Missense_Mutation_p.R86Q|NOL4_uc002kxr.3_Missense_Mutation_p.R207Q|NOL4_uc010xbt.1_Missense_Mutation_p.R297Q|NOL4_uc010dmh.2_Missense_Mutation_p.R297Q|NOL4_uc010xbu.1_Missense_Mutation_p.R371Q|NOL4_uc002kxt.3_Missense_Mutation_p.R371Q|NOL4_uc010xbv.1_Missense_Mutation_p.R120Q|NOL4_uc010xbw.1_Missense_Mutation_p.R257Q	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	371						nucleolus	RNA binding			ovary(3)	3						CTCAGCTCCTCGGTCTACACT	0.453													11	351					0	0	0	0	T	31538327	T	T	31538327	3	4	52	1	0	0	0	0	1	0	0	0	10578	884	31	1	824	1	NOL4	18	31538327	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08		31538327	46538921	166	10469											
MBD1	4152	broad.mit.edu	37	chr18	47799971	47799971	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggaagctgcaacagggcccGgcacctgcacaggactgctt	9	6	13	13	1	0	0	0	0	0	0	0	2	0	2	2	4	5	5	2	4	2	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:47799971G>A	uc010dow.1	-	12	1846	c.1409C>T	c.(1408-1410)CCG>CTG	p.P470L	MBD1_uc002lef.2_Missense_Mutation_p.P221L|MBD1_uc002leg.2_Missense_Mutation_p.P420L|MBD1_uc010xdi.1_Missense_Mutation_p.P521L|MBD1_uc002leh.3_Missense_Mutation_p.P414L|MBD1_uc002len.2_Missense_Mutation_p.P470L|MBD1_uc002lei.3_Missense_Mutation_p.P470L|MBD1_uc002lej.3_Missense_Mutation_p.P414L|MBD1_uc002lek.3_Missense_Mutation_p.P421L|MBD1_uc002lel.3_Missense_Mutation_p.P447L|MBD1_uc002lem.3_Missense_Mutation_p.P470L|MBD1_uc010xdj.1_Missense_Mutation_p.P414L|MBD1_uc010xdk.1_Missense_Mutation_p.P495L|MBD1_uc010dox.1_Missense_Mutation_p.P447L|MBD1_uc002leo.2_Missense_Mutation_p.P470L	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	470					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AACAGGGCCCGGCACCTGCAC	0.637													28	32					0	0	0	0	A	47799971	A	A	47799971	3	1	52	1	0	0	0	0	1	0	0	0	9395	1116	39	1	622	1	MBD1	18	47799971	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	16261644	47799971	30277277	167	10470											
CXXC1	30827	broad.mit.edu	37	chr18	47812188	47812188	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggggcccccgaacttcttCatgtcccgacagaaatcaca	10	9	8	14	2	3	1	2	0	1	1	4	3	4	1	3	2	1	0	3	2	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:47812188C>T	uc002leq.3	-	5	1303	c.570G>A	c.(568-570)ATG>ATA	p.M190I	CXXC1_uc002lep.3_Missense_Mutation_p.M47I|CXXC1_uc002ler.3_Missense_Mutation_p.M190I|CXXC1_uc010doy.2_Missense_Mutation_p.M190I|CXXC1_uc002les.2_Missense_Mutation_p.M190I	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	190	CXXC-type.				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CGAACTTCTTCATGTCCCGAC	0.577													61	104					0	0	0	0	T	47812188	T	T	47812188	3	4	52	1	0	0	0	0	1	0	0	0	4114	826	29	2	1456	2	CXXC1	18	47812188	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	12217	47812188	30265060	168	10471											
SALL3	27164	broad.mit.edu	37	chr18	76754440	76754440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctgaaggacgcggccaccGacccggccaagccactcctg	9	3	12	17	4	0	1	0	1	0	0	1	3	1	2	6	3	2	1	6	3	2	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:76754440G>A	uc002lmt.2	+	2	2449	c.2449G>A	c.(2449-2451)GAC>AAC	p.D817N	SALL3_uc010dra.2_Missense_Mutation_p.D424N	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	817					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CGCGGCCACCGACCCGGCCAA	0.642													14	12					0	0	0	0	A	76754440	A	A	76754440	3	1	52	1	0	0	0	0	1	0	0	0	13877	1058	37	1	2455	1	SALL3	18	76754440	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	28942252	76754440	1322808	169	10472											
C18orf22	79863	broad.mit.edu	37	chr18	77806103	77806103	+	Missense_Mutation	SNP	G	A	A																															agaggagttggaggcagagaGaggaggtggcagaacagagg																										TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:77806103G>A	uc002lns.2	+	7	1118	c.980G>A	c.(979-981)AGA>AAA	p.R327K	C18orf22_uc010drh.2_3'UTR|C18orf22_uc010dri.1_Intron|C18orf22_uc002lnt.2_Missense_Mutation_p.R160K|uc002lnu.2_5'Flank	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	327					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		GAGGCAGAGAGAGGAGGTGGC	0.582													3	48					0	0	0	0	A	77806103	A	A	77806103	3	1	52	1	0	0	0	0	1	0	0	0	1907	942	33	2	1006	2	C18orf22	18	77806103	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	1051663	77806103	271145	170	10473	24	2									
C18orf22	79863	broad.mit.edu	37	chr18	77806105	77806105	+	Missense_Mutation	SNP	G	A	A																															aggagttggaggcagagagaGgaggtggcagaacagaggat																								rs138311529		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:77806105G>A	uc002lns.2	+	7	1120	c.982G>A	c.(982-984)GGA>AGA	p.G328R	C18orf22_uc010drh.2_3'UTR|C18orf22_uc010dri.1_Intron|C18orf22_uc002lnt.2_Missense_Mutation_p.G161R|uc002lnu.2_5'Flank	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	328					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		GGCAGAGAGAGGAGGTGGCAG	0.587													3	49					0	0	0	0	A	77806105	A	A	77806105	3	1	52	1	0	0	0	0	1	0	0	0	1907	1001	35	4	1008	4	C18orf22	18	77806105	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	2	77806105	271143	171	10474	24	2									
DOT1L	84444	broad.mit.edu	37	chr19	2213555	2213555	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caggagaagaacgcccagctCctgggtgcggctcagcagct	9	5	14	13	2	1	2	1	0	0	2	2	3	2	2	2	3	5	4	2	3	2	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:2213555C>T	uc002lvb.3	+	17	1611	c.1575C>T	c.(1573-1575)CTC>CTT	p.L525L	DOT1L_uc002lvc.1_5'UTR|uc002lvd.1_RNA|DOT1L_uc002lve.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	525						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCCCAGCTCCTGGGTGCGG	0.617													24	21					0	0	0	0	T	2213555	T	T	2213555	2	4	52	1	0	0	0	0	0	0	0	1	4731	842	30	2		2	DOT1L	19	2213555	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08		2213555	56915428	172	10475											
ZNF136	7695	broad.mit.edu	37	chr19	12296616	12296616	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggactcggtggcttttgAggatgtagatgtgaacttca	9	13	13	6	1	2	3	2	2	0	1	3	5	2	5	0	4	1	2	0	4	2	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:12296616A>G	uc002mti.2	+	2	120	c.20A>G	c.(19-21)GAG>GGG	p.E7G	ZNF136_uc010xmh.1_Intron	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	7	KRAB.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						GTGGCTTTTGAGGATGTAGAT	0.483													3	99					0	0	0	0	G	12296616	G	G	12296616	3	3	52	1	0	0	0	0	1	0	0	0	17793	304	11	5	26	5	ZNF136	19	12296616	Missense_Mutation	SNP	A	TCGA-CN-4741-01A-01D-1434-08	10083061	12296616	46832367	173	10476											
DAND5	199699	broad.mit.edu	37	chr19	13080366	13080366	+	5'Flank	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggggccaagagattaaaaGcaggttcagaaggctcagat	15	6	14	6	0	2	3	2	0	0	3	2	5	2	3	1	4	1	3	1	4	4	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:13080366G>C	uc002mwc.1	+						DAND5_uc010dyz.1_5'UTR	NM_152654	NP_689867	Q8N907	DAND5_HUMAN	dante precursor							extracellular region				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			GAGATTAAAAGCAGGTTCAGA	0.488													4	52					0	0	0	0	C	13080366	C	C	13080366	1	2	52	0	1	0	0	0	0	0	0	0	4247	986	34	4		4	DAND5	19	13080366	5'Flank	SNP	G	TCGA-CN-4741-01A-01D-1434-08	783750	13080366	46048617	174	10477											
F2RL3	9002	broad.mit.edu	37	chr19	17001171	17001171	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggccttcttcgtgcccagCaacctgctgctgctgctgca	4	11	11	15	1	1	0	0	0	1	0	2	0	1	0	3	1	8	6	3	1	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:17001171C>A	uc002nfa.2	+	2	1072	c.897C>A	c.(895-897)AGC>AGA	p.S299R		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	299	Helical; Name=6; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						TCGTGCCCAGCAACCTGCTGC	0.701													9	8					0.000274275	0.000296574	1	0	A	17001171	A	A	17001171	3	1	52	1	0	0	0	0	1	0	0	0	5371	709	25	4	903	4	F2RL3	19	17001171	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	3920805	17001171	42127812	175	10478											
MAP1S	55201	broad.mit.edu	37	chr19	17845129	17845129	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggccatgcatacgtggtaCgcagagacgcacgcccggca	9	5	14	13	5	0	1	0	0	0	1	0	2	0	1	2	3	3	5	2	3	2	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:17845129C>T	uc002nhe.1	+	7	3081	c.3072C>T	c.(3070-3072)TAC>TAT	p.Y1024Y	MAP1S_uc010eba.1_Intron|MAP1S_uc002nhf.1_Silent_p.Y272Y|MAP1S_uc010xpv.1_Silent_p.Y998Y	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	1024	Necessary for association with actin (By similarity).|Necessary for interaction with RASSF1 isoform A and isoform C.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						ATACGTGGTACGCAGAGACGC	0.657													21	52					0	0	0	0	T	17845129	T	T	17845129	2	4	52	1	0	0	0	0	0	0	0	1	9287	547	19	1		1	MAP1S	19	17845129	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	843958	17845129	41283854	176	10479											
ZNF676	163223	broad.mit.edu	37	chr19	22363197	22363197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttctctccagcatgaattCtcttgtgttcagtaaggctt	7	17	8	9	0	3	1	1	1	2	0	6	1	4	1	1	1	1	5	1	1	2	6			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:22363197C>T	uc002nqs.1	-	3	1640	c.1322G>A	c.(1321-1323)AGA>AAA	p.R441K		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	441	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AGCATGAATTCTCTTGTGTTC	0.438													90	159					0	0	0	0	T	22363197	T	T	22363197	3	4	52	1	0	0	0	0	1	0	0	0	18150	913	32	2	448	2	ZNF676	19	22363197	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	4518068	22363197	36765786	177	10480											
ZFP14	57677	broad.mit.edu	37	chr19	36853022	36853022	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaataaccttacctagtgaaAtgaagttgctgtagttctcc	13	13	7	8	0	1	2	0	2	1	0	2	2	1	2	3	0	3	4	3	0	7	6			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:36853022A>T	uc002odx.1	-	2	221	c.128T>A	c.(127-129)ATT>AAT	p.I43N	ZFP14_uc010xtd.1_Missense_Mutation_p.I43N|ZFP14_uc010eex.1_Missense_Mutation_p.I43N	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	43	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					ACCTAGTGAAATGAAGTTGCT	0.378													48	73					0	0	0	0	T	36853022	T	T	36853022	3	4	52	1	0	0	0	0	1	0	0	0	17706	101	4	5	1485	5	ZFP14	19	36853022	Missense_Mutation	SNP	A	TCGA-CN-4741-01A-01D-1434-08	14489825	36853022	22275961	178	10481											
ZNF569	148266	broad.mit.edu	37	chr19	37903739	37903739	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcttttccacatttattacaTtcatagggtttttcacctgt	8	19	5	9	0	2	0	2	0	0	0	3	0	3	0	2	1	1	2	2	1	3	9			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:37903739T>C	uc002ogi.2	-	6	2379	c.1821A>G	c.(1819-1821)GAA>GAG	p.E607E	ZNF569_uc002ogh.2_Silent_p.E448E|ZNF569_uc002ogj.2_Silent_p.E631E	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	607	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTTATTACATTCATAGGGTT	0.413													83	149					0	0	0	0	C	37903739	C	C	37903739	2	2	52	1	0	0	0	0	0	0	0	1	18067	1490	52	5		5	ZNF569	19	37903739	Silent	SNP	T	TCGA-CN-4741-01A-01D-1434-08	1050717	37903739	21225244	179	10482											
LGALS4	3960	broad.mit.edu	37	chr19	39297125	39297125	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccggaggggctggcctccGatgaagttgattgattgaag	8	9	17	7	2	0	4	0	4	0	0	1	6	1	5	3	5	0	2	3	5	2	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:39297125G>A	uc002ojg.2	-	4	664	c.450C>T	c.(448-450)ATC>ATT	p.I150I	LGALS4_uc010xuj.1_Silent_p.I150I	NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	150	Galectin 1.				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GCTGGCCTCCGATGAAGTTGA	0.488													7	137					0	0	0	0	A	39297125	A	A	39297125	2	1	52	1	0	0	0	0	0	0	0	1	8785	1048	37	1		1	LGALS4	19	39297125	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	1393386	39297125	19831858	180	10483											
PSG7	5676	broad.mit.edu	37	chr19	43439678	43439678	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggatcagcagggatgcattgGaatatactgtttctcatcca	11	12	10	8	0	2	0	2	0	1	0	4	3	3	3	1	3	3	3	1	3	3	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:43439678G>C	uc002ovl.3	-	3	410	c.308C>G	c.(307-309)TCC>TGC	p.S103C	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	103	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GGATGCATTGGAATATACTGT	0.428													6	611					0	0	0	0	C	43439678	C	C	43439678	3	2	52	1	0	0	0	0	1	0	0	0	12722	1174	41	2	971	2	PSG7	19	43439678	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	4142553	43439678	15689305	181	10484											
QPCTL	54814	broad.mit.edu	37	chr19	46206184	46206184	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtacccgtgctccatctcatCtccacgcccttccctgctgt	4	12	6	19	2	2	0	1	0	2	0	6	0	4	0	5	0	3	3	5	0	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:46206184C>T	uc010xxr.1	+	7	1247	c.1026C>T	c.(1024-1026)ATC>ATT	p.I342I	QPCTL_uc010ekn.2_Silent_p.I248I	NM_017659	NP_060129	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like isoform	342					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		TCCATCTCATCTCCACGCCCT	0.597													30	226					0	0	0	0	T	46206184	T	T	46206184	2	4	52	1	0	0	0	0	0	0	0	1	12940	903	32	2		2	QPCTL	19	46206184	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	2766506	46206184	12922799	182	10485											
ZNF468	90333	broad.mit.edu	37	chr19	53344519	53344519	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaagtatagtatgttttGccagatatgaattatatgcg	12	16	10	3	1	0	3	0	2	0	1	0	3	0	3	1	0	2	3	1	0	8	8			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:53344519G>C	uc002qaf.2	-	4	1179	c.1028C>G	c.(1027-1029)GCA>GGA	p.A343G	ZNF468_uc002qae.2_Missense_Mutation_p.A290G	NM_001008801	NP_001008801	Q5VIY5	ZN468_HUMAN	zinc finger protein ZNF468 isoform 2	343	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0358)		AGTATGTTTTGCCAGATATGA	0.378													5	210					0	0	0	0	C	53344519	C	C	53344519	3	2	52	1	0	0	0	0	1	0	0	0	17995	1319	46	4	544	4	ZNF468	19	53344519	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	7138335	53344519	5784464	183	10486											
LILRA3	11026	broad.mit.edu	37	chr19	54803659	54803659	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctatatagatggtactcctgCgtctccaggctcccctgaca	8	11	8	14	1	1	2	0	1	1	1	4	2	3	2	4	2	2	2	4	2	4	4	rs138979811	byFrequency	TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:54803659C>T	uc002qfd.2	-	3	230	c.165G>A	c.(163-165)ACG>ACA	p.T55T	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.T55T	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	55	Ig-like C2-type 1.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGTACTCCTGCGTCTCCAGGC	0.567													11	97					0	0	0	0	T	54803659	T	T	54803659	2	4	52	1	0	0	0	0	0	0	0	1	8827	755	27	1		1	LILRA3	19	54803659	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	1459140	54803659	4325324	184	10487											
NLRP2	55655	broad.mit.edu	37	chr19	55494891	55494891	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaggagctcctcggctgtCtgtacgagtctcaggaggag	7	9	15	10	2	2	0	1	0	2	0	5	4	3	3	1	4	3	4	1	4	1	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:55494891C>T	uc002qij.2	+	6	1911	c.1825C>T	c.(1825-1827)CTG>TTG	p.L609L	NLRP2_uc010yfp.1_Silent_p.L586L|NLRP2_uc010esn.2_Silent_p.L585L|NLRP2_uc010eso.2_Silent_p.L606L|NLRP2_uc010esp.2_Silent_p.L587L	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	609					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CCTCGGCTGTCTGTACGAGTC	0.507													3	33					0	0	0	0	T	55494891	T	T	55494891	2	4	52	1	0	0	0	0	0	0	0	1	10531	912	32	2		2	NLRP2	19	55494891	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	691232	55494891	3634092	185	10488											
ZNF471	57573	broad.mit.edu	37	chr19	57037187	57037187	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggcttttagtgatagctCatcctgtgctcagcatcaaa	12	12	8	9	0	3	1	3	1	0	0	4	1	4	1	1	1	3	4	1	1	4	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:57037187C>T	uc002qnh.2	+	5	1884	c.1751C>T	c.(1750-1752)TCA>TTA	p.S584L		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	584	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		AGTGATAGCTCATCCTGTGCT	0.413													16	105					0	0	0	0	T	57037187	T	T	57037187	3	4	52	1	0	0	0	0	1	0	0	0	17997	838	29	2	1765	2	ZNF471	19	57037187	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	1542296	57037187	2091796	186	10489											
ZSCAN4	201516	broad.mit.edu	37	chr19	58189827	58189827	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagtcctcccctgagtctGcccttacccaccagagcaat	9	8	7	17	0	1	2	0	1	1	1	3	2	3	2	6	0	4	2	6	0	2	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:58189827G>T	uc002qpu.2	+	5	1553	c.856G>T	c.(856-858)GCC>TCC	p.A286S		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	286					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCTGAGTCTGCCCTTACCCA	0.483													6	145					0.00116845	0.00125325	1	0	T	58189827	T	T	58189827	3	4	52	1	0	0	0	0	1	0	0	0	18304	1319	46	4	866	4	ZSCAN4	19	58189827	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	1152640	58189827	939156	187	10490											
ZNF544	27300	broad.mit.edu	37	chr19	58772699	58772699	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggaaagaaaaacccttatGaatatattgtcagtggtgac	16	10	9	6	0	1	3	1	2	0	1	1	4	1	4	1	2	1	0	1	2	7	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:58772699G>A	uc010euo.2	+	7	1201	c.727G>A	c.(727-729)GAA>AAA	p.E243K	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.E215K|ZNF544_uc010yhy.1_Missense_Mutation_p.E215K|ZNF544_uc002qrt.3_Missense_Mutation_p.E101K|ZNF544_uc002qru.3_Missense_Mutation_p.E101K|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		AAACCCTTATGAATATATTGT	0.388													9	207					0	0	0	0	A	58772699	A	A	58772699	3	1	52	1	0	0	0	0	1	0	0	0	18044	1291	45	2	741	2	ZNF544	19	58772699	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	582872	58772699	356284	188	10491											
RALGAPB	57148	broad.mit.edu	37	chr20	37150172	37150172	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctagcatggagtttcgaCggaaagggtcacaaatgtcc	13	8	12	8	2	1	0	1	0	0	0	3	3	2	2	1	3	2	3	1	3	4	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr20:37150172C>T	uc002xiw.2	+	10	1707	c.1450C>T	c.(1450-1452)CGG>TGG	p.R484W	RALGAPB_uc010zvz.1_Intron|RALGAPB_uc002xix.2_Missense_Mutation_p.R484W|RALGAPB_uc002xiy.1_Missense_Mutation_p.R484W|RALGAPB_uc002xiz.2_Missense_Mutation_p.R262W|RALGAPB_uc002xja.1_Missense_Mutation_p.R211W	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	484					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						GGAGTTTCGACGGAAAGGGTC	0.453													5	238					0	0	0	0	T	37150172	T	T	37150172	3	4	52	1	0	0	0	0	1	0	0	0	13080	527	19	1	1484	1	RALGAPB	20	37150172	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08		37150172	25875348	189	10492											
MYT1	4661	broad.mit.edu	37	chr20	62839236	62839236	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtcgtcgaagtcaccacCgagcgctcccaggacctgtg	8	6	13	14	4	1	0	1	0	0	0	4	4	2	1	4	2	1	1	4	2	1	0			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr20:62839236C>T	uc002yii.2	+	7	1051	c.687C>T	c.(685-687)ACC>ACT	p.T229T	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	229	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AAGTCACCACCGAGCGCTCCC	0.572													11	77					0	0	0	0	T	62839236	T	T	62839236	2	4	52	1	0	0	0	0	0	0	0	1	10159	639	23	1		1	MYT1	20	62839236	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	25689064	62839236	186284	190	10493											
GCFC1	94104	broad.mit.edu	37	chr21	34116017	34116017	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atataagggcataaatacatCatcatctaaagttcttctca	16	13	4	8	0	5	0	3	0	3	0	6	0	5	0	0	1	1	2	0	1	7	7			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr21:34116017C>T	uc002yqn.2	-	14	2429	c.2239G>A	c.(2239-2241)GAT>AAT	p.D747N	GCFC1_uc002yql.2_Missense_Mutation_p.D256N|GCFC1_uc002yqm.2_Missense_Mutation_p.D241N|GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Missense_Mutation_p.D747N	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	747						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						ATAAATACATCATCATCTAAA	0.289													11	24					0	0	0	0	T	34116017	T	T	34116017	3	4	52	1	0	0	0	0	1	0	0	0	6324	826	29	2	652	2	GCFC1	21	34116017	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08		34116017	14013878	191	10494											
KRTAP12-4	386684	broad.mit.edu	37	chr21	46074247	46074247	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctatagaccagggtggggcaGaagggctggcagcacccaga	11	4	16	10	0	0	3	0	0	0	3	0	3	0	3	2	5	1	4	2	5	3	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr21:46074247G>A	uc002zfs.1	-	1	330	c.285C>T	c.(283-285)TTC>TTT	p.F95F	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198698	NP_941971	P60329	KR124_HUMAN	keratin associated protein 12-4	95	15 X 5 AA approximate repeats.|14.					keratin filament				ovary(1)	1						GGGTGGGGCAGAAGGGCTGGC	0.632													4	100					0	0	0	0	A	46074247	A	A	46074247	2	1	52	1	0	0	0	0	0	0	0	1	8560	933	33	2		2	KRTAP12-4	21	46074247	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	11958230	46074247	2055648	192	10495											
POFUT2	23275	broad.mit.edu	37	chr21	46702265	46702265	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggggcctggggcactcaccGggctgatgtgtttctcagca	5	9	16	11	1	2	1	2	1	1	0	3	1	2	1	2	5	1	4	2	5	0	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr21:46702265G>A	uc002zhc.2	-	4	662	c.637C>T	c.(637-639)CGG>TGG	p.R213W	POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_Missense_Mutation_p.R213W|POFUT2_uc011afp.1_Missense_Mutation_p.R213W	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	213					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)		GGCACTCACCGGGCTGATGTG	0.667													41	51					0	0	0	0	A	46702265	A	A	46702265	3	1	52	1	0	0	0	0	1	0	0	0	12239	1130	39	1	815	1	POFUT2	21	46702265	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	628018	46702265	1427630	193	10496											
PCNT	5116	broad.mit.edu	37	chr21	47783638	47783638	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctgaaatgaggcagcttCaggaccaacaggcagcccag	14	4	12	11	0	1	2	1	2	0	0	1	3	1	3	2	3	4	4	2	3	3	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr21:47783638C>G	uc002zji.3	+	14	2505	c.2398C>G	c.(2398-2400)CAG>GAG	p.Q800E	PCNT_uc002zjj.2_Missense_Mutation_p.Q682E	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	800	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GAGGCAGCTTCAGGACCAACA	0.522													3	96					0	0	0	0	G	47783638	G	G	47783638	3	3	52	1	0	0	0	0	1	0	0	0	11644	827	29	2	2452	2	PCNT	21	47783638	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	1081373	47783638	346257	194	10497											
CECR1	51816	broad.mit.edu	37	chr22	17688100	17688100	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccttggggtgaaacagatgtGgcagtgaggcctgtaggtga	9	9	17	6	0	0	4	0	3	0	1	0	4	0	4	2	5	1	2	2	5	2	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr22:17688100G>A	uc002zmk.1	-	2	615	c.403C>T	c.(403-405)CAC>TAC	p.H135Y	CECR1_uc010gqu.1_Missense_Mutation_p.H135Y|CECR1_uc011agi.1_Missense_Mutation_p.H93Y|CECR1_uc011agj.1_Missense_Mutation_p.H93Y	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	135	PRB domain.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				AAACAGATGTGGCAGTGAGGC	0.522													48	89					0	0	0	0	A	17688100	A	A	17688100	3	1	52	1	0	0	0	0	1	0	0	0	3220	1348	47	4	1198	4	CECR1	22	17688100	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08		17688100	33616466	195	10498											
SERPIND1	3053	broad.mit.edu	37	chr22	21138321	21138321	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaacttccggctgaatgaGagagaggtagttaaggtttc	12	10	12	7	1	0	3	0	2	0	2	2	5	1	3	1	3	1	4	1	3	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr22:21138321G>A	uc002ztb.1	+	3	1018	c.951G>A	c.(949-951)GAG>GAA	p.E317E	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Silent_p.E345E	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	317					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	GGCTGAATGAGAGAGAGGTAG	0.502											OREG0026325	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	270					0	0	0	0	A	21138321	A	A	21138321	2	1	52	1	0	0	0	0	0	0	0	1	14175	933	33	2		2	SERPIND1	22	21138321	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	3450221	21138321	30166245	196	10499											
SFI1	9814	broad.mit.edu	37	chr22	32007798	32007798	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctggcacagagactcagccGgacctgcttccgccagtgga	8	6	13	14	2	1	1	1	0	0	1	2	4	2	3	4	3	2	3	4	3	0	1			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr22:32007798G>A	uc003ale.2	+	24	2855	c.2462G>A	c.(2461-2463)CGG>CAG	p.R821Q	SFI1_uc003alf.2_Missense_Mutation_p.R790Q|SFI1_uc003alg.2_Missense_Mutation_p.R739Q|SFI1_uc011alp.1_Missense_Mutation_p.R727Q|SFI1_uc011alq.1_Missense_Mutation_p.R766Q|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA|SFI1_uc003ali.2_5'Flank|SFI1_uc003alj.2_5'Flank	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	821					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						AGACTCAGCCGGACCTGCTTC	0.617													21	31					0	0	0	0	A	32007798	A	A	32007798	3	1	52	1	0	0	0	0	1	0	0	0	14221	1116	39	1	2552	1	SFI1	22	32007798	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	10869477	32007798	19296768	197	10500											
PACSIN2	11252	broad.mit.edu	37	chr22	43275154	43275154	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctctccggctgagggttcGattcaggtctgcggaccact	5	11	12	13	3	3	1	1	1	2	0	6	3	4	2	2	4	1	2	2	4	0	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr22:43275154G>A	uc010gzg.2	-	8	1150	c.928C>T	c.(928-930)CGA>TGA	p.R310*	PACSIN2_uc003bdg.3_Nonsense_Mutation_p.R310*|PACSIN2_uc003bde.3_Nonsense_Mutation_p.R310*|PACSIN2_uc003bdf.3_Nonsense_Mutation_p.R310*	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	310					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				CTGAGGGTTCGATTCAGGTCT	0.592													5	101					0	0	0	0	A	43275154	A	A	43275154	4	1	52	1	0	0	0	0	0	1	0	0	11429	1066	37	1	548	1	PACSIN2	22	43275154	Nonsense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	11267356	43275154	8029412	198	10501											
CSF2RA	1438	broad.mit.edu	37	chrX	1409269	1409269	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccttattacatacaagaCtcaggaacccatgtgggatg	12	11	9	9	0	1	1	1	0	0	1	2	3	2	3	2	2	3	0	2	2	5	3			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:1409269C>T	uc010nct.2	+	8	835	c.513C>T	c.(511-513)GAC>GAT	p.D171D	CSF2RA_uc011mhb.1_Silent_p.D171D|CSF2RA_uc004cpq.2_Silent_p.D171D|CSF2RA_uc004cpn.2_Silent_p.D171D|CSF2RA_uc004cpo.2_Silent_p.D171D|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Silent_p.D38D|CSF2RA_uc004cpp.2_Silent_p.D171D|CSF2RA_uc010ncv.2_Silent_p.D171D|CSF2RA_uc004cpr.2_Silent_p.D171D	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	171	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ACATACAAGACTCAGGAACCC	0.333													96	61					0	0	0	0	T	1409269	T	T	1409269	2	4	52	1	0	0	0	0	0	0	0	1	3951	564	20	4		4	CSF2RA	23	1409269	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08		1409269	153861291	199	10502											
YY2	404281	broad.mit.edu	37	chrX	21875244	21875244	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgattattccgagtacttGaaagggaagaaacttcctcc	12	11	8	10	1	0	3	0	2	0	1	3	5	3	4	4	1	2	1	4	1	5	5			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:21875244G>A	uc011mjp.1	+	1	642	c.642G>A	c.(640-642)TTG>TTA	p.L214L	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Silent_p.L432L|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						CCGAGTACTTGAAAGGGAAGA	0.483													9	192					0	0	0	0	A	21875244	A	A	21875244	2	1	52	1	0	0	0	0	0	0	0	1	17577	1281	45	2		2	YY2	23	21875244	Silent	SNP	G	TCGA-CN-4741-01A-01D-1434-08	20465975	21875244	133395316	200	10503											
ACRC	93953	broad.mit.edu	37	chrX	70823703	70823703	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcggatgttcccgacgacaaCagtgatgattcatccgacga	11	9	10	11	5	1	2	1	2	0	0	4	7	3	3	2	1	1	1	2	1	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:70823703C>T	uc004eae.2	+	8	1077	c.576C>T	c.(574-576)AAC>AAT	p.N192N	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	192	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					CCGACGACAACAGTGATGATT	0.498													6	245					0	0	0	0	T	70823703	T	T	70823703	2	4	52	1	0	0	0	0	0	0	0	1	171	477	17	4		4	ACRC	23	70823703	Silent	SNP	C	TCGA-CN-4741-01A-01D-1434-08	48948459	70823703	84446857	201	10504											
ZNF711	7552	broad.mit.edu	37	chrX	84502625	84502625	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgcacacgccagactctaGaatggcccataccatgatta	13	9	7	12	1	1	3	0	1	1	2	1	3	1	3	3	1	2	1	3	1	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:84502625G>T	uc004eeo.2	+	3	394	c.47G>T	c.(46-48)AGA>ATA	p.R16I	ZNF711_uc004eep.2_Missense_Mutation_p.R16I|ZNF711_uc004eeq.2_Missense_Mutation_p.R16I	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	16					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						CCAGACTCTAGAATGGCCCAT	0.333													20	101					4.35082e-09	4.96703e-09	1	0	T	84502625	T	T	84502625	3	4	52	1	0	0	0	0	1	0	0	0	18183	942	33	2	49	2	ZNF711	23	84502625	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	13678922	84502625	70767935	202	10505											
IRS4	8471	broad.mit.edu	37	chrX	107978638	107978638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttttgggcaaccacacagtCatcgacctgcatccagagct	10	9	9	13	1	1	1	1	0	0	1	3	2	2	1	3	1	3	4	3	1	1	2			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:107978638C>T	uc004eoc.2	-	1	970	c.937G>A	c.(937-939)GAC>AAC	p.D313N		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	313	IRS-type PTB.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						ACCACACAGTCATCGACCTGC	0.547													6	169					0	0	0	0	T	107978638	T	T	107978638	3	4	52	1	0	0	0	0	1	0	0	0	7881	826	29	2	2840	2	IRS4	23	107978638	Missense_Mutation	SNP	C	TCGA-CN-4741-01A-01D-1434-08	23476013	107978638	47291922	203	10506											
HTATSF1	27336	broad.mit.edu	37	chrX	135581841	135581841	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttctaccgcaaatgttgaaGatgtccatgctaggactgca	11	11	10	9	1	1	2	0	1	1	1	2	3	2	3	2	1	3	5	2	1	4	4			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:135581841G>C	uc004ezw.2	+	3	693	c.271G>C	c.(271-273)GAT>CAT	p.D91H	HTATSF1_uc004ezx.2_Missense_Mutation_p.D91H	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	91					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AAATGTTGAAGATGTCCATGC	0.443													9	117					0	0	0	0	C	135581841	C	C	135581841	3	2	52	1	0	0	0	0	1	0	0	0	7472	942	33	2	277	2	HTATSF1	23	135581841	Missense_Mutation	SNP	G	TCGA-CN-4741-01A-01D-1434-08	27603203	135581841	19688719	204	10507											
PRKCZ	5590	broad.mit.edu	37	chr1	2103541	2103541	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctcaacttcctgcacgagaGggggatcatctacagggacc	10	7	11	13	1	3	1	2	0	1	1	4	4	4	3	3	3	3	1	3	3	2	2	rs147033679		TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr1:2103541G>A	uc001aiq.2	+	12	1270	c.1109G>A	c.(1108-1110)AGG>AAG	p.R370K	PRKCZ_uc001air.2_Missense_Mutation_p.R187K|PRKCZ_uc010nyw.1_Missense_Mutation_p.R266K|PRKCZ_uc001ais.2_Missense_Mutation_p.R187K|PRKCZ_uc009vla.2_Missense_Mutation_p.R194K|PRKCZ_uc010nyx.1_RNA|PRKCZ_uc001ait.2_Missense_Mutation_p.R218K	NM_002744	NP_002735	Q05513	KPCZ_HUMAN	protein kinase C, zeta isoform 1	370	Protein kinase.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CTGCACGAGAGGGGGATCATC	0.627													9	81					0	0	0	0	A	2103541	A	A	2103541	3	1	53	1	0	0	0	0	1	0	0	0	12579	1000	35	4	1155	4	PRKCZ	1	2103541	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08		2103541	247147080	1	10508											
MAP3K6	9064	broad.mit.edu	37	chr1	27690423	27690423	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcacctgcacatcgcggtaGgagagcagcaagttcatgat	11	7	12	11	3	1	2	1	1	0	1	2	3	1	2	1	2	3	6	1	2	2	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr1:27690423G>A	uc001bny.1	-	5	1098	c.849C>T	c.(847-849)TCC>TCT	p.S283S	MAP3K6_uc009vsw.1_Silent_p.S275S|MAP3K6_uc001bnz.1_5'Flank	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	283					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CATCGCGGTAGGAGAGCAGCA	0.373													4	32					0	0	0	0	A	27690423	A	A	27690423	2	1	53	1	0	0	0	0	0	0	0	1	9307	987	35	4		4	MAP3K6	1	27690423	Silent	SNP	G	TCGA-CN-4742-01A-02D-1512-08	25586882	27690423	221560198	2	10509											
SNRNP40	9410	broad.mit.edu	37	chr1	31754270	31754270	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taatctgatcacttgtgtcaTtgaaggtcacagctaacacc	12	12	7	10	0	4	2	3	2	1	0	4	2	4	2	1	1	2	1	1	1	3	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr1:31754270T>A	uc001bso.2	-	5	651	c.605A>T	c.(604-606)AAT>ATT	p.N202I	SNRNP40_uc010oge.1_Missense_Mutation_p.N202I	NM_004814	NP_004805	Q96DI7	SNR40_HUMAN	WD repeat domain 57 (U5 snRNP specific)	202	WD 4.					catalytic step 2 spliceosome|cytoplasm|nucleoplasm|small nucleolar ribonucleoprotein complex|U5 snRNP	protein binding				0						ACTTGTGTCATTGAAGGTCAC	0.393													22	66					0	0	0	0	A	31754270	A	A	31754270	3	1	53	1	0	0	0	0	1	0	0	0	14920	1493	52	5	492	5	SNRNP40	1	31754270	Missense_Mutation	SNP	T	TCGA-CN-4742-01A-02D-1512-08	4063847	31754270	217496351	3	10510											
OLFM3	118427	broad.mit.edu	37	chr1	102290781	102290781	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatcaaaggcaggagctcGtccattttctctttcaactc	9	12	9	11	1	3	0	2	0	1	0	7	2	4	2	1	3	2	2	1	3	2	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr1:102290781G>A	uc001duf.2	-	4	524	c.453C>T	c.(451-453)GAC>GAT	p.D151D	OLFM3_uc001dug.2_Silent_p.D131D|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Silent_p.D56D|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	151	Potential.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		GCAGGAGCTCGTCCATTTTCT	0.408													4	37					0	0	0	0	A	102290781	A	A	102290781	2	1	53	1	0	0	0	0	0	0	0	1	10908	1136	40	1		1	OLFM3	1	102290781	Silent	SNP	G	TCGA-CN-4742-01A-02D-1512-08	70536511	102290781	146959840	4	10511											
CD53	963	broad.mit.edu	37	chr1	111434046	111434046	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acggcatgggcatgagtagcTtgaaactgctgaagtatgtc	11	10	13	7	1	0	3	0	3	0	0	1	3	0	3	0	2	3	6	0	2	4	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr1:111434046T>A	uc001dzw.2	+	3	187	c.16T>A	c.(16-18)TTG>ATG	p.L6M	CD53_uc001dzx.2_Missense_Mutation_p.L6M|CD53_uc010owa.1_Missense_Mutation_p.L6M|CD53_uc001dzy.2_Missense_Mutation_p.L6M	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	6	Cytoplasmic (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		CATGAGTAGCTTGAAACTGCT	0.438													6	125					0	0	0	0	A	111434046	A	A	111434046	3	1	53	1	0	0	0	0	1	0	0	0	3038	1606	56	5	18	5	CD53	1	111434046	Missense_Mutation	SNP	T	TCGA-CN-4742-01A-02D-1512-08	9143265	111434046	137816575	5	10512											
HRNR	388697	broad.mit.edu	37	chr1	152192431	152192431	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccatacccatgtgggccAtagctggaagactgcctgga	10	7	13	11	0	0	1	0	0	0	1	0	4	0	3	4	3	4	1	4	3	3	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr1:152192431A>G	uc001ezt.1	-	3	1750	c.1674T>C	c.(1672-1674)TAT>TAC	p.Y558Y		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	558	5.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGTGGGCCATAGCTGGAAG	0.582													30	171					0	0	0	0	G	152192431	G	G	152192431	2	3	53	1	0	0	0	0	0	0	0	1	7398	224	8	5		5	HRNR	1	152192431	Silent	SNP	A	TCGA-CN-4742-01A-02D-1512-08	40758385	152192431	97058190	6	10513											
MNDA	4332	broad.mit.edu	37	chr1	158815770	158815770	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagcatctggaacaatggtgTatgggttgtttatgttacaa	12	14	11	4	0	1	0	0	0	1	0	1	1	1	1	0	3	3	5	0	3	7	5			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr1:158815770T>G	uc001fsz.1	+	5	1164	c.964T>G	c.(964-966)TAT>GAT	p.Y322D		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	322	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					AACAATGGTGTATGGGTTGTT	0.323													19	111					0	0	0	0	G	158815770	G	G	158815770	3	3	53	1	0	0	0	0	1	0	0	0	9729	1638	57	5	978	5	MNDA	1	158815770	Missense_Mutation	SNP	T	TCGA-CN-4742-01A-02D-1512-08	6623339	158815770	90434851	7	10514											
KLHDC8A	55220	broad.mit.edu	37	chr1	205306589	205306589	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accctggttgacacctcccaCggcgaggaggcagttcttga	8	8	12	13	2	1	2	0	2	1	0	2	4	2	3	3	4	0	3	3	4	0	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr1:205306589C>T	uc001hcf.1	-	6	1559	c.991G>A	c.(991-993)GTG>ATG	p.V331M	KLHDC8A_uc010prg.1_Missense_Mutation_p.V218M|KLHDC8A_uc001hcg.1_Missense_Mutation_p.V331M	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	331										ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACACCTCCCACGGCGAGGAGG	0.592													29	180					0	0	0	0	T	205306589	T	T	205306589	3	4	53	1	0	0	0	0	1	0	0	0	8401	536	19	1	65	1	KLHDC8A	1	205306589	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	46490819	205306589	43944032	8	10515											
XPO1	7514	broad.mit.edu	37	chr2	61719223	61719223	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgttgttcaaaatttcatCaataaatggcatcacttctc	14	15	4	8	0	5	0	4	0	1	0	6	0	5	0	0	1	0	3	0	1	6	5			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:61719223C>T	uc002sbj.2	-	16	2562	c.1834G>A	c.(1834-1836)GAT>AAT	p.D612N	XPO1_uc010fcl.2_Missense_Mutation_p.D608N|XPO1_uc010ypn.1_Missense_Mutation_p.D608N|XPO1_uc002sbk.2_Missense_Mutation_p.D173N|XPO1_uc002sbh.2_Missense_Mutation_p.D259N	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	612	HEAT 6.|Necessary for HTLV-1 Rex-mediated mRNA export.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			AAAATTTCATCAATAAATGGC	0.363													14	87					0	0	0	0	T	61719223	T	T	61719223	3	4	53	1	0	0	0	0	1	0	0	0	17513	826	29	2	1421	2	XPO1	2	61719223	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08		61719223	181480150	9	10516											
ADD2	119	broad.mit.edu	37	chr2	70890768	70890768	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgaggatttcctctgccGtctgctcctcctccctcccg	2	13	8	18	2	2	1	0	1	2	0	7	2	7	2	6	1	3	2	6	1	0	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:70890768G>A	uc002sgz.2	-	16	2435	c.1970C>T	c.(1969-1971)ACG>ATG	p.T657M	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_3'UTR|ADD2_uc002sha.2_Missense_Mutation_p.T351M|ADD2_uc002sgx.2_3'UTR	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	657					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						TTCCTCTGCCGTCTGCTCCTC	0.572													15	154					0	0	0	0	A	70890768	A	A	70890768	3	1	53	1	0	0	0	0	1	0	0	0	305	1145	40	1	214	1	ADD2	2	70890768	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	9171545	70890768	172308605	10	10517											
REV1	51455	broad.mit.edu	37	chr2	100022563	100022563	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttccagatccacagcagcccGaaatactacaaaaagaaaat	19	6	5	11	1	0	2	0	0	0	2	2	3	2	2	3	0	4	1	3	0	7	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:100022563G>A	uc002tad.2	-	17	2832	c.2620C>T	c.(2620-2622)CGG>TGG	p.R874W	REV1_uc002tac.2_Missense_Mutation_p.R873W	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	874					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						ACAGCAGCCCGAAATACTACA	0.398								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					4	26					0	0	0	0	A	100022563	A	A	100022563	3	1	53	1	0	0	0	0	1	0	0	0	13304	1057	37	1	1163	1	REV1	2	100022563	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	29131795	100022563	143176810	11	10518											
CCDC74B	91409	broad.mit.edu	37	chr2	130899886	130899886	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccggctctacccacactcCgttgatgcagacccagcgag	8	7	9	17	3	1	2	0	1	1	1	3	3	3	2	4	1	3	3	4	1	1	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:130899886C>T	uc002tqm.1	-	3	426	c.364G>A	c.(364-366)GGA>AGA	p.G122R	CCDC74B_uc010yzw.1_Missense_Mutation_p.G224R|CCDC74B_uc002tqn.1_Intron|CCDC74B_uc010yzx.1_3'UTR	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	122											0	Colorectal(110;0.1)					ACCCACACTCCGTTGATGCAG	0.652													6	82					0	0	0	0	T	130899886	T	T	130899886	3	4	53	1	0	0	0	0	1	0	0	0	2861	661	23	1	802	1	CCDC74B	2	130899886	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	30877323	130899886	112299487	12	10519											
CCDC74A	90557	broad.mit.edu	37	chr2	132288220	132288220	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgctgggtctgcatcaacGgagtgtgggtagagccggga	7	8	17	9	3	2	1	1	0	1	1	3	3	2	3	1	4	3	3	1	4	2	1	rs148324548		TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:132288220G>A	uc002tta.2	+	3	416	c.364G>A	c.(364-366)GGA>AGA	p.G122R	CCDC74A_uc002ttb.2_Intron	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	122										skin(1)	1						CTGCATCAACGGAGTGTGGGT	0.657													6	64					0	0	0	0	A	132288220	A	A	132288220	3	1	53	1	0	0	0	0	1	0	0	0	2860	1117	39	1	374	1	CCDC74A	2	132288220	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	1388334	132288220	110911153	13	10520											
MBD5	55777	broad.mit.edu	37	chr2	149243425	149243425	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaacagcagcaacttctccAggggtaccagaatctccagg	12	6	10	13	0	2	1	0	0	2	1	4	1	2	1	3	3	5	4	3	3	4	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:149243425A>C	uc002twm.3	+	11	3948	c.2960A>C	c.(2959-2961)CAG>CCG	p.Q987P	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.Q987P|MBD5_uc002two.2_Missense_Mutation_p.Q245P|MBD5_uc002twp.2_Missense_Mutation_p.Q37P	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	987						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CAACTTCTCCAGGGGTACCAG	0.443													9	101					0	0	0	0	C	149243425	C	C	149243425	3	2	53	1	0	0	0	0	1	0	0	0	9400	188	7	5	2982	5	MBD5	2	149243425	Missense_Mutation	SNP	A	TCGA-CN-4742-01A-02D-1512-08	16955205	149243425	93955948	14	10521											
TANC1	85461	broad.mit.edu	37	chr2	160050872	160050872	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctcaccttggccacgaggaAgttgtcactctgctcctgga	7	11	10	13	1	3	0	2	0	2	0	5	3	4	2	3	3	1	2	3	3	1	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:160050872A>T	uc002uag.2	+	17	3121	c.2847A>T	c.(2845-2847)GAA>GAT	p.E949D	TANC1_uc010zcm.1_Missense_Mutation_p.E941D|TANC1_uc010fom.1_Missense_Mutation_p.E755D	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	949	ANK 2.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						GCCACGAGGAAGTTGTCACTC	0.557													27	83					0	0	0	0	T	160050872	T	T	160050872	3	4	53	1	0	0	0	0	1	0	0	0	15610	69	3	5	2905	5	TANC1	2	160050872	Missense_Mutation	SNP	A	TCGA-CN-4742-01A-02D-1512-08	10807447	160050872	83148501	15	10522											
HOXD13	3239	broad.mit.edu	37	chr2	176958146	176958146	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgtcaggcctggcgagcagCagcgtaccggccaacgaggt	8	5	16	12	4	1	0	1	0	0	0	1	2	1	0	3	4	5	3	3	4	2	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:176958146C>T	uc002ukf.1	+	1	615	c.528C>T	c.(526-528)AGC>AGT	p.S176S		NM_000523	NP_000514	P35453	HXD13_HUMAN	homeobox D13	176					skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		TGGCGAGCAGCAGCGTACCGG	0.622			T	NUP98	AML*								4	85					0	0	0	0	T	176958146	T	T	176958146	2	4	53	1	0	0	0	0	0	0	0	1	7361	709	25	4		4	HOXD13	2	176958146	Silent	SNP	C	TCGA-CN-4742-01A-02D-1512-08	16907274	176958146	66241227	16	10523											
TTN	7273	broad.mit.edu	37	chr2	179497431	179497431	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccaacggaatgttttgggCtccctggatacttcacactc	9	11	9	12	1	1	0	1	0	0	0	3	2	2	2	2	3	3	2	2	3	3	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:179497431C>A	uc010zfg.1	-	184	35822	c.35598G>T	c.(35596-35598)GAG>GAT	p.E11866D	TTN_uc010zfh.1_Missense_Mutation_p.E5561D|TTN_uc010zfi.1_Missense_Mutation_p.E5494D|TTN_uc010zfj.1_Missense_Mutation_p.E5369D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12793							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTTTTGGGCTCCCTGGATA	0.418													29	211					3.65163e-15	4.26562e-15	1	0	A	179497431	A	A	179497431	3	1	53	1	0	0	0	0	1	0	0	0	16803	796	28	4	64903	4	TTN	2	179497431	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	2539285	179497431	63701942	17	10524											
INPP5D	3635	broad.mit.edu	37	chr2	234078797	234078797	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatcttaactaccgtgtggAtctgcctacctgggtaaggg	8	11	13	9	1	2	0	0	0	2	0	2	2	2	2	3	4	4	1	3	4	4	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:234078797A>G	uc010zmo.1	+	14	1931	c.1778A>G	c.(1777-1779)GAT>GGT	p.D593G	INPP5D_uc010zmp.1_Missense_Mutation_p.D592G	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	593					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TACCGTGTGGATCTGCCTACC	0.522													8	36					0	0	0	0	G	234078797	G	G	234078797	3	3	53	1	0	0	0	0	1	0	0	0	7795	333	12	5	1344	5	INPP5D	2	234078797	Missense_Mutation	SNP	A	TCGA-CN-4742-01A-02D-1512-08	54581366	234078797	9120576	18	10525											
COL6A3	1293	broad.mit.edu	37	chr2	238253407	238253407	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accacatctcgcatccggccGaaagtgtcttggttgactcc	8	10	9	14	3	2	1	0	1	2	0	5	2	4	1	4	2	0	2	4	2	1	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr2:238253407G>A	uc002vwl.2	-	36	7539	c.7254C>T	c.(7252-7254)TTC>TTT	p.F2418F	COL6A3_uc002vwo.2_Silent_p.F2212F|COL6A3_uc010znj.1_Silent_p.F1811F|COL6A3_uc002vwj.2_5'Flank|COL6A3_uc002vwp.1_Silent_p.F239F	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2418	VWFA 11.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCATCCGGCCGAAAGTGTCTT	0.567													17	136					0	0	0	0	A	238253407	A	A	238253407	2	1	53	1	0	0	0	0	0	0	0	1	3716	1049	37	1		1	COL6A3	2	238253407	Silent	SNP	G	TCGA-CN-4742-01A-02D-1512-08	4174610	238253407	4945966	19	10526											
LHFPL4	375323	broad.mit.edu	37	chr3	9547694	9547694	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcctgcagcaggtctgtttgCcggttgcccagcacgaaggc	6	9	13	13	2	1	0	0	0	1	0	2	1	2	0	3	3	5	5	3	3	1	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr3:9547694C>T	uc003bry.2	-	3	886	c.600G>A	c.(598-600)CGG>CGA	p.R200R		NM_198560	NP_940962	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4	200						integral to membrane				ovary(2)|skin(1)	3	Medulloblastoma(99;0.227)					GGTCTGTTTGCCGGTTGCCCA	0.657													4	160					0	0	0	0	T	9547694	T	T	9547694	2	4	53	1	0	0	0	0	0	0	0	1	8808	726	26	4		4	LHFPL4	3	9547694	Silent	SNP	C	TCGA-CN-4742-01A-02D-1512-08		9547694	188474736	20	10527											
PARP3	10039	broad.mit.edu	37	chr3	51979165	51979165	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacttttacaccgtcatcccGcacaacttcggccacagcca	10	8	5	18	3	1	0	1	0	0	0	3	0	2	0	4	1	3	1	4	1	2	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr3:51979165G>A	uc003dby.2	+	6	1157	c.786G>A	c.(784-786)CCG>CCA	p.P262P	PARP3_uc003dbz.2_Silent_p.P269P	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	262	PARP alpha-helical.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCGTCATCCCGCACAACTTCG	0.637													4	126					0	0	0	0	A	51979165	A	A	51979165	2	1	53	1	0	0	0	0	0	0	0	1	11516	1074	38	1		1	PARP3	3	51979165	Silent	SNP	G	TCGA-CN-4742-01A-02D-1512-08	42431471	51979165	146043265	21	10528											
PTPRG	5793	broad.mit.edu	37	chr3	62261572	62261572	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcacacagtgtaatgcaaaaTatgtggaatgtttcagtgct	13	13	9	6	0	2	0	2	0	0	0	2	1	2	1	0	1	2	4	0	1	5	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr3:62261572T>C	uc003dlb.2	+	24	4209	c.3490T>C	c.(3490-3492)TAT>CAT	p.Y1164H	PTPRG_uc003dlc.2_Missense_Mutation_p.Y1135H|PTPRG_uc011bfi.1_Missense_Mutation_p.Y410H|uc010hno.2_Intron|uc003dld.3_Intron|uc010hnp.2_Intron|uc003dle.3_Intron	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1164	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		TAATGCAAAATATGTGGAATG	0.328													12	32					0	0	0	0	C	62261572	C	C	62261572	3	2	53	1	0	0	0	0	1	0	0	0	12867	1406	49	5	3584	5	PTPRG	3	62261572	Missense_Mutation	SNP	T	TCGA-CN-4742-01A-02D-1512-08	10282407	62261572	135760858	22	10529											
PARP15	165631	broad.mit.edu	37	chr3	122354765	122354765	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaagcacatgtacgttgtgCgagtacttactggagtcttc	10	12	11	8	2	1	0	0	0	1	0	2	3	1	1	0	1	5	4	0	1	4	5			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr3:122354765C>T	uc003efm.2	+	12	1921	c.1855C>T	c.(1855-1857)CGA>TGA	p.R619*	PARP15_uc003efn.2_Nonsense_Mutation_p.R424*|PARP15_uc003efo.1_Nonsense_Mutation_p.R366*|PARP15_uc003efp.1_Nonsense_Mutation_p.R385*|PARP15_uc011bjt.1_Nonsense_Mutation_p.R316*	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	597	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		GTACGTTGTGCGAGTACTTAC	0.478													4	146					0	0	0	0	T	122354765	T	T	122354765	4	4	53	1	0	0	0	0	0	1	0	0	11513	760	27	1	1970	1	PARP15	3	122354765	Nonsense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	60093193	122354765	75667665	23	10530											
ZBTB38	253461	broad.mit.edu	37	chr3	141164513	141164514	+	Frame_Shift_Del	DEL	CA	-	-																															atactggagaaaagcgttacCactgtcagttctgctttcag																										TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr3:141164513_141164514delCA	uc003etw.2	+	8	4265_4266	c.3283_3284delCA	c.(3283-3285)CACfs	p.H1095fs	ZBTB38_uc010hun.2_Frame_Shift_Del_p.H1092fs|ZBTB38_uc010huo.2_Frame_Shift_Del_p.H1095fs|ZBTB38_uc003ety.2_Frame_Shift_Del_p.H1095fs|ZBTB38_uc010hup.2_Frame_Shift_Del_p.H1096fs	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	1095	C2H2-type 9.				positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AAAGCGTTACCACTGTCAGTTC	0.455													---	---	---								-	141164514	-	-	141164513	7	5	53	1	0	1	0	1	0	0	0	0	17606	594	21	0	3285	0	ZBTB38	3	141164513	Frame_Shift_Del	DEL	CA	TCGA-CN-4742-01A-02D-1512-08	18809748	141164513	56857917	24	10531											
ZIC4	84107	broad.mit.edu	37	chr3	147108803	147108803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtccgacgagggcgacaCgagggcagacggtgtagccg	9	3	18	11	6	0	1	0	0	0	1	1	5	1	1	2	3	1	3	2	3	1	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr3:147108803C>T	uc003ewd.1	-	4	1192	c.919G>A	c.(919-921)GTG>ATG	p.V307M	ZIC4_uc003ewc.1_Missense_Mutation_p.V237M|ZIC4_uc011bno.1_Missense_Mutation_p.V357M	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	307						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GAGGGCGACACGAGGGCAGAC	0.687													8	41					0	0	0	0	T	147108803	T	T	147108803	3	4	53	1	0	0	0	0	1	0	0	0	17748	536	19	1	93	1	ZIC4	3	147108803	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	5944290	147108803	50913627	25	10532											
BBS12	166379	broad.mit.edu	37	chr4	123664753	123664753	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgcctgctcagggtggcTgcataatacttcctcttggc	6	12	10	13	0	2	0	1	0	1	0	3	0	3	0	3	3	4	3	3	3	2	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr4:123664753T>A	uc003ieu.2	+	2	1899	c.1706T>A	c.(1705-1707)CTG>CAG	p.L569Q		NM_152618	NP_689831	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	569					cellular protein metabolic process	cilium	ATP binding			ovary(2)	2						TCAGGGTGGCTGCATAATACT	0.433									Bardet-Biedl_syndrome				7	92					0	0	0	0	A	123664753	A	A	123664753	3	1	53	1	0	0	0	0	1	0	0	0	1339	1580	55	5	1708	5	BBS12	4	123664753	Missense_Mutation	SNP	T	TCGA-CN-4742-01A-02D-1512-08		123664753	67489523	26	10533											
NEIL3	55247	broad.mit.edu	37	chr4	178272610	178272610	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatggactccgtggctcggAagtcggaagagcactggacc	9	8	14	10	3	0	1	0	0	0	1	3	5	1	5	2	5	1	2	2	5	3	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr4:178272610A>T	uc003iut.2	+	7	1063	c.946A>T	c.(946-948)AAG>TAG	p.K316*	NEIL3_uc010irs.2_Intron	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	316					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		CGTGGCTCGGAAGTCGGAAGA	0.423								BER_DNA_glycosylases					18	153					0	0	0	0	T	178272610	T	T	178272610	4	4	53	1	0	0	0	0	0	1	0	0	10374	247	9	5	972	5	NEIL3	4	178272610	Nonsense_Mutation	SNP	A	TCGA-CN-4742-01A-02D-1512-08	54607857	178272610	12881666	27	10534											
PLCXD3	345557	broad.mit.edu	37	chr5	41381991	41381991	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccacagtgctagctttggggGtcagcaccacctgagatata	10	9	11	11	0	1	1	1	1	0	1	1	2	1	1	3	2	3	3	3	2	3	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr5:41381991G>T	uc003jmm.1	-	2	851	c.749C>A	c.(748-750)ACC>AAC	p.T250N		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	250					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						AGCTTTGGGGGTCAGCACCAC	0.433													14	110					4.36969e-10	4.92991e-10	1	0	T	41381991	T	T	41381991	3	4	53	1	0	0	0	0	1	0	0	0	12098	1261	44	4	224	4	PLCXD3	5	41381991	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08		41381991	139533269	28	10535											
RIOK2	55781	broad.mit.edu	37	chr5	96519049	96519049	+	5'Flank	DEL	T	-	-																															gttaatagttagaagtgctgTtctcattgatataggaaaat																										TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr5:96519049delT	uc003kmz.2	-						RIOK2_uc003kna.3_5'Flank	NM_018343	NP_060813	Q9BVS4	RIOK2_HUMAN	RIO kinase 2 isoform 1								ATP binding|protein serine/threonine kinase activity			kidney(1)	1		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		AGAAGTGCTGTTCTCATTGAT	0.403													---	---	---								-	96519049	-	-	96519049	6	5	53	0	1	1	0	1	0	0	0	0	13443	1740	60	0		0	RIOK2	5	96519049	5'Flank	DEL	T	TCGA-CN-4742-01A-02D-1512-08	55137058	96519049	84396211	29	10536											
SKP1	6500	broad.mit.edu	37	chr5	133502896	133502896	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcattcacatttggtagagGaactgggtcatcatctcctt	9	14	9	9	0	4	1	3	0	1	1	5	2	4	2	1	3	2	2	1	3	2	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr5:133502896G>A	uc003kzc.3	-	3	315	c.136C>T	c.(136-138)CCT>TCT	p.P46S	SKP1_uc003kzd.3_Missense_Mutation_p.P46S|SKP1_uc010jdv.2_Missense_Mutation_p.P46S	NM_170679	NP_733779	P63208	SKP1_HUMAN	S-phase kinase-associated protein 1 isoform b	46					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|histone H2A monoubiquitination|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTTGGTAGAGGAACTGGGTCA	0.313													27	75					0	0	0	0	A	133502896	A	A	133502896	3	1	53	1	0	0	0	0	1	0	0	0	14426	1174	41	2	398	2	SKP1	5	133502896	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	36983847	133502896	47412364	30	10537											
LECT2	3950	broad.mit.edu	37	chr5	135288629	135288629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattggaagacttgccagcaCatatattagcccatggccct	11	10	8	12	0	0	1	0	0	0	1	0	2	0	2	3	2	3	1	3	2	4	5			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr5:135288629C>T	uc003lbe.1	-	2	275	c.74G>A	c.(73-75)TGT>TAT	p.C25Y		NM_002302	NP_002293	O14960	LECT2_HUMAN	leukocyte cell-derived chemotaxin 2 precursor	25					chemotaxis|skeletal system development	cytoplasm|extracellular space				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTTGCCAGCACATATATTAGC	0.517													23	133					0	0	0	0	T	135288629	T	T	135288629	3	4	53	1	0	0	0	0	1	0	0	0	8753	478	17	4	393	4	LECT2	5	135288629	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	1785733	135288629	45626631	31	10538											
RBM27	54439	broad.mit.edu	37	chr5	145641354	145641354	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgctccttcaacagtgcaCggaggtatccagaaggtaat	11	10	10	10	1	2	1	1	0	1	1	4	2	4	2	2	3	3	4	2	3	4	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr5:145641354C>T	uc003lnz.3	+	13	2341	c.2175C>T	c.(2173-2175)CAC>CAT	p.H725H	RBM27_uc003lny.2_Silent_p.H670H	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	725					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAACAGTGCACGGAGGTATCC	0.478													21	53					0	0	0	0	T	145641354	T	T	145641354	2	4	53	1	0	0	0	0	0	0	0	1	13192	535	19	1		1	RBM27	5	145641354	Silent	SNP	C	TCGA-CN-4742-01A-02D-1512-08	10352725	145641354	35273906	32	10539											
GABRB2	2561	broad.mit.edu	37	chr5	160763740	160763740	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttactgcattatcatcgccaCgccagtaaaactcaatgtca	13	11	5	12	2	3	0	3	0	0	0	4	0	3	0	2	0	3	2	2	0	5	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr5:160763740C>T	uc003lys.1	-	7	796	c.578G>A	c.(577-579)CGT>CAT	p.R193H	GABRB2_uc011deh.1_Missense_Mutation_p.R32H|GABRB2_uc003lyr.1_Missense_Mutation_p.R193H|GABRB2_uc003lyt.1_Missense_Mutation_p.R193H|GABRB2_uc010jiu.1_Missense_Mutation_p.R130H	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	193	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATCATCGCCACGCCAGTAAAA	0.279													15	82					0	0	0	0	T	160763740	T	T	160763740	3	4	53	1	0	0	0	0	1	0	0	0	6201	536	19	1	980	1	GABRB2	5	160763740	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	15122386	160763740	20151520	33	10540											
ZNF184	7738	broad.mit.edu	37	chr6	27419915	27419915	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttccacattcattgcattTgtaaggtttttctccagtat	8	19	5	9	0	2	0	1	0	1	0	4	0	3	0	2	1	1	4	2	1	2	8			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr6:27419915T>C	uc003njj.2	-	5	2234	c.1423A>G	c.(1423-1425)AAA>GAA	p.K475E	ZNF184_uc010jqv.2_Missense_Mutation_p.K475E|ZNF184_uc003nji.2_Missense_Mutation_p.K475E	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	475	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCATTGCATTTGTAAGGTTTT	0.418													5	80					0	0	0	0	C	27419915	C	C	27419915	3	2	53	1	0	0	0	0	1	0	0	0	17818	1821	63	5	836	5	ZNF184	6	27419915	Missense_Mutation	SNP	T	TCGA-CN-4742-01A-02D-1512-08		27419915	143695152	34	10541											
OR12D3	81797	broad.mit.edu	37	chr6	29342553	29342553	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtagaagaagtgattgagtTtctgagagccacaaaaactc	15	9	10	7	1	1	5	0	3	1	3	2	6	1	5	1	0	2	2	1	0	5	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr6:29342553T>G	uc003nme.2	-	1	516	c.512A>C	c.(511-513)AAA>ACA	p.K171T		NM_030959	NP_112221	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3						GTGATTGAGTTTCTGAGAGCC	0.463													11	61					0	0	0	0	G	29342553	G	G	29342553	3	3	53	1	0	0	0	0	1	0	0	0	10986	1841	64	5	442	5	OR12D3	6	29342553	Missense_Mutation	SNP	T	TCGA-CN-4742-01A-02D-1512-08	1922638	29342553	141772514	35	10542											
SYNCRIP	10492	broad.mit.edu	37	chr6	86328627	86328627	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatttcaatattttctccctCcaagtctttgccattcattt	9	19	2	11	0	4	0	2	0	2	0	6	0	5	0	3	0	1	0	3	0	4	7			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr6:86328627C>T	uc003pla.2	-	10	1730	c.1189G>A	c.(1189-1191)GAG>AAG	p.E397K	SYNCRIP_uc003pku.2_Missense_Mutation_p.E397K|SYNCRIP_uc003pkw.2_Missense_Mutation_p.E362K|SYNCRIP_uc003pky.2_Missense_Mutation_p.E299K|SYNCRIP_uc003pkv.2_Missense_Mutation_p.E397K|SYNCRIP_uc003pkx.2_Missense_Mutation_p.E245K|SYNCRIP_uc003pkz.2_Missense_Mutation_p.E362K	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	397	RRM 3.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		TTTTCTCCCTCCAAGTCTTTG	0.318													4	51					0	0	0	0	T	86328627	T	T	86328627	3	4	53	1	0	0	0	0	1	0	0	0	15510	864	30	2	736	2	SYNCRIP	6	86328627	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	56986074	86328627	84786440	36	10543											
GPRC6A	222545	broad.mit.edu	37	chr6	117130586	117130586	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtagctggaatagtcacacTtaaactccacagtttctctg	11	13	7	10	0	2	0	1	0	1	0	4	1	3	1	1	1	2	3	1	1	5	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr6:117130586T>G	uc003pxj.1	-	2	411	c.389A>C	c.(388-390)AAG>ACG	p.K130T	GPRC6A_uc003pxk.1_Missense_Mutation_p.K130T|GPRC6A_uc003pxl.1_Missense_Mutation_p.K130T	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	130	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATAGTCACACTTAAACTCCAC	0.423													17	81					0	0	0	0	G	117130586	G	G	117130586	3	3	53	1	0	0	0	0	1	0	0	0	6767	1609	56	5	2411	5	GPRC6A	6	117130586	Missense_Mutation	SNP	T	TCGA-CN-4742-01A-02D-1512-08	30801959	117130586	53984481	37	10544											
TNFAIP3	7128	broad.mit.edu	37	chr6	138200423	138200423	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaaaagccggctgcgtgtAttttgggactccagaaaaca	13	8	11	9	2	0	2	0	0	0	2	1	3	1	3	2	2	3	2	2	2	5	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr6:138200423A>G	uc003qhr.2	+	7	1907	c.1841A>G	c.(1840-1842)TAT>TGT	p.Y614C	TNFAIP3_uc003qhs.2_Missense_Mutation_p.Y614C	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	614	Interaction with NAF1 (By similarity).|A20-type 4.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		GGCTGCGTGTATTTTGGGACT	0.542			D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								15	95					0	0	0	0	G	138200423	G	G	138200423	3	3	53	1	0	0	0	0	1	0	0	0	16340	449	16	5	1863	5	TNFAIP3	6	138200423	Missense_Mutation	SNP	A	TCGA-CN-4742-01A-02D-1512-08	21069837	138200423	32914644	38	10545											
MLLT4	4301	broad.mit.edu	37	chr6	168226811	168226811	+	5'Flank	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgggacccatcgcccgtTcggacccagcaccgcccgtc	6	5	10	20	5	0	0	0	0	0	0	3	2	0	2	6	2	1	2	6	2	0	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr6:168226811T>C	uc003qwd.2	+						MLLT4_uc003qwb.1_5'Flank|MLLT4_uc003qwc.1_5'Flank|C6orf124_uc003qwa.2_RNA	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia						adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CATCGCCCGTTCGGACCCAGC	0.687			T	MLL	AL								6	162					0	0	0	0	C	168226811	C	C	168226811	1	2	53	0	1	0	0	0	0	0	0	0	9682	1798	62	5		5	MLLT4	6	168226811	5'Flank	SNP	T	TCGA-CN-4742-01A-02D-1512-08	30026388	168226811	2888256	39	10546											
RADIL	55698	broad.mit.edu	37	chr7	4856927	4856927	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaccacctcctccagcacCgccatggcctcctcgctggc	6	6	8	21	2	0	0	0	0	0	0	4	0	3	0	8	2	2	3	8	2	0	0			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr7:4856927C>T	uc003snj.1	-	7	1844	c.1671G>A	c.(1669-1671)GCG>GCA	p.A557A	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Silent_p.A62A|RADIL_uc011jwc.1_Silent_p.A317A|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	557	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CCTCCAGCACCGCCATGGCCT	0.642													21	44					0	0	0	0	T	4856927	T	T	4856927	2	4	53	1	0	0	0	0	0	0	0	1	13062	639	23	1		1	RADIL	7	4856927	Silent	SNP	C	TCGA-CN-4742-01A-02D-1512-08		4856927	154281736	40	10547											
THSD7A	221981	broad.mit.edu	37	chr7	11630169	11630169	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acctctcgggtctggatgccCcctccacagagggccgtctg	5	8	12	16	2	3	1	0	0	3	1	5	2	4	2	5	3	1	0	5	3	0	0			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr7:11630169C>T	uc003ssf.3	-	4	1623	c.1371G>A	c.(1369-1371)GGG>GGA	p.G457G		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	457	Extracellular (Potential).|TSP type-1 4.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TCTGGATGCCCCCTCCACAGA	0.552										HNSCC(18;0.044)			10	48					0	0	0	0	T	11630169	T	T	11630169	2	4	53	1	0	0	0	0	0	0	0	1	15945	610	22	4		4	THSD7A	7	11630169	Silent	SNP	C	TCGA-CN-4742-01A-02D-1512-08	6773242	11630169	147508494	41	10548											
EGFR	1956	broad.mit.edu	37	chr7	55227956	55227956	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttgtgctatgcaaatacaAtaaactggaaaaaactgttt	17	13	6	5	0	0	0	0	0	0	0	0	1	0	1	0	1	5	3	0	1	9	5			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr7:55227956A>G	uc003tqk.2	+	12	1669	c.1423A>G	c.(1423-1425)ATA>GTA	p.I475V	EGFR_uc003tqi.2_Missense_Mutation_p.I475V|EGFR_uc003tqj.2_Missense_Mutation_p.I475V|EGFR_uc010kzg.1_Missense_Mutation_p.I430V|EGFR_uc011kco.1_Missense_Mutation_p.I422V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_Intron	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	475	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCAAATACAATAAACTGGAA	0.393		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			21	46					0	0	0	0	G	55227956	G	G	55227956	3	3	53	1	0	0	0	0	1	0	0	0	4989	101	4	5	1480	5	EGFR	7	55227956	Missense_Mutation	SNP	A	TCGA-CN-4742-01A-02D-1512-08	43597787	55227956	103910707	42	10549											
C7orf23	79161	broad.mit.edu	37	chr7	86826067	86826067	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaagtctccttgtcgatacCagtagatctaaaagaagaat	15	11	7	8	1	2	3	0	0	2	3	4	4	2	3	2	0	1	1	2	0	7	5			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr7:86826067C>T	uc003uio.2	-	4	454	c.242G>A	c.(241-243)TGG>TAG	p.W81*		NM_024315	NP_077291	Q9BU79	CG023_HUMAN	chromosome 7 open reading frame 23	81	Helical; (Potential).					integral to membrane					0	Esophageal squamous(14;0.0058)|all_lung(186;0.191)|Lung NSC(181;0.192)					TTGTCGATACCAGTAGATCTA	0.264										HNSCC(41;0.11)			13	47					0	0	0	0	T	86826067	T	T	86826067	4	4	53	1	0	0	0	0	0	1	0	0	2390	595	21	4	118	4	C7orf23	7	86826067	Nonsense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	31598111	86826067	72312596	43	10550											
PPP1R3A	5506	broad.mit.edu	37	chr7	113520174	113520174	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggttcttattaagtgttGatttatcttatgggataaaa	11	19	8	3	0	3	1	0	1	3	0	3	2	3	2	0	2	0	2	0	2	6	8			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr7:113520174G>T	uc010ljy.1	-	4	1004	c.973C>A	c.(973-975)CAA>AAA	p.Q325K		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	325					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ATTAAGTGTTGATTTATCTTA	0.299													9	78					0.000274275	0.000287336	1	0	T	113520174	T	T	113520174	3	4	53	1	0	0	0	0	1	0	0	0	12431	1299	45	2	2399	2	PPP1R3A	7	113520174	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	26694107	113520174	45618489	44	10551											
GRM8	2918	broad.mit.edu	37	chr7	126882877	126882877	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcacacttcacatccgaagCatctttctctattaatgcct	11	13	4	13	1	3	0	1	0	2	0	5	1	4	0	2	0	3	2	2	0	3	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr7:126882877C>A	uc003vlr.2	-	1	693	c.382G>T	c.(382-384)GCT>TCT	p.A128S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.A128S|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	128	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	ACATCCGAAGCATCTTTCTCT	0.502										HNSCC(24;0.065)			9	81					1.12685e-05	1.23954e-05	1	0	A	126882877	A	A	126882877	3	1	53	1	0	0	0	0	1	0	0	0	6842	710	25	4	2434	4	GRM8	7	126882877	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	13362703	126882877	32255786	45	10552											
EXOC4	60412	broad.mit.edu	37	chr7	133602486	133602486	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagaggaggaagaagatttCataaggtaaaaggtccattt	17	9	12	3	0	1	3	1	0	0	3	2	6	2	5	1	4	0	1	1	4	5	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr7:133602486C>G	uc003vrk.2	+	13	2057	c.2022C>G	c.(2020-2022)TTC>TTG	p.F674L	EXOC4_uc011kpo.1_Missense_Mutation_p.F573L|EXOC4_uc003vrl.2_Missense_Mutation_p.F284L|EXOC4_uc011kpp.1_Missense_Mutation_p.F206L	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	674					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AAGAAGATTTCATAAGGTAAA	0.358													5	60					0	0	0	0	G	133602486	G	G	133602486	3	3	53	1	0	0	0	0	1	0	0	0	5330	825	29	2	2081	2	EXOC4	7	133602486	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	6719609	133602486	25536177	46	10553											
ZFAT	57623	broad.mit.edu	37	chr8	135649949	135649949	+	Frame_Shift_Del	DEL	A	-	-																															ctctcttcctcttcatgaccAaaaactctacagaggaaaca																										TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr8:135649949delA	uc003yup.2	-	3	378	c.203delT	c.(202-204)TTGfs	p.L68fs	ZFAT_uc003yun.2_Frame_Shift_Del_p.L56fs|ZFAT_uc003yuo.2_Frame_Shift_Del_p.L56fs|ZFAT_uc010meh.2_Frame_Shift_Del_p.L56fs|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Frame_Shift_Del_p.L56fs|ZFAT_uc010mej.2_Frame_Shift_Del_p.L68fs|ZFAT_uc003yur.2_Frame_Shift_Del_p.L56fs	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTTCATGACCAAAAACTCTAC	0.517													---	---	---								-	135649949	-	-	135649949	7	5	53	1	0	1	0	1	0	0	0	0	17699	131	5	0	3584	0	ZFAT	8	135649949	Frame_Shift_Del	DEL	A	TCGA-CN-4742-01A-02D-1512-08		135649949	10714073	47	10554											
NOTCH1	4851	broad.mit.edu	37	chr9	139412381	139412381	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttgcccgcatgctcgcaggGgttggcacctggcgagggca	5	7	16	13	3	0	0	0	0	0	0	1	1	0	0	2	5	2	6	2	5	0	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr9:139412381G>A	uc004chz.2	-	8	1264	c.1264C>T	c.(1264-1266)CCC>TCC	p.P422S		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	422	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TGCTCGCAGGGGTTGGCACCT	0.667			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			17	35					0	0	0	0	A	139412381	A	A	139412381	3	1	53	1	0	0	0	0	1	0	0	0	10601	1232	43	4	6511	4	NOTCH1	9	139412381	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08		139412381	1801050	48	10555											
RSU1	6251	broad.mit.edu	37	chr10	16794619	16794619	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aagctccccgatttccttagGcagcgagatcaggtcgttat	9	11	10	11	3	1	1	1	0	0	1	4	3	3	1	3	2	2	3	3	2	3	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr10:16794619G>T	uc001iok.2	-	6	819	c.517C>A	c.(517-519)CCT>ACT	p.P173T	RSU1_uc001iol.2_Missense_Mutation_p.P173T|RSU1_uc001iom.2_Missense_Mutation_p.P120T|RSU1_uc001ion.2_Missense_Mutation_p.P173T	NM_152724	NP_689937	Q15404	RSU1_HUMAN	ras suppressor protein 1 isoform 2	173	LRR 6.				cell junction assembly|signal transduction	cytosol	protein binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(1;7.54e-08)		ATTTCCTTAGGCAGCGAGATC	0.473													14	106					1.49906e-05	1.63534e-05	1	0	T	16794619	T	T	16794619	3	4	53	1	0	0	0	0	1	0	0	0	13781	1203	42	4	328	4	RSU1	10	16794619	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08		16794619	118740128	49	10556											
CUBN	8029	broad.mit.edu	37	chr10	17168789	17168789	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttggaattttctctcaaGatccaccagctggcaatagg	10	11	9	11	0	2	1	1	0	1	1	4	2	3	2	3	3	1	2	3	3	4	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr10:17168789G>C	uc001ioo.2	-	4	410	c.358C>G	c.(358-360)CTT>GTT	p.L120V		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	120					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTTCTCTCAAGATCCACCAGC	0.408													22	61					0	0	0	0	C	17168789	C	C	17168789	3	2	53	1	0	0	0	0	1	0	0	0	4068	942	33	2	10769	2	CUBN	10	17168789	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	374170	17168789	118365958	50	10557											
FAM13C	220965	broad.mit.edu	37	chr10	61028362	61028362	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcaaatttccgaattttcCgcttgaggctctggatgtgc	7	15	9	10	2	2	1	1	1	1	0	4	3	4	2	2	2	1	2	2	2	2	5			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr10:61028362C>A	uc001jkn.2	-	9	1027	c.893G>T	c.(892-894)CGG>CTG	p.R298L	FAM13C_uc001jko.2_Missense_Mutation_p.R298L|FAM13C_uc010qid.1_Missense_Mutation_p.R215L|FAM13C_uc010qie.1_Missense_Mutation_p.R215L|FAM13C_uc010qif.1_Missense_Mutation_p.R320L|FAM13C_uc001jkp.2_Missense_Mutation_p.R215L	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	298										ovary(2)	2						CCGAATTTTCCGCTTGAGGCT	0.502													6	52					3.59834e-05	3.86163e-05	1	0	A	61028362	A	A	61028362	3	1	53	1	0	0	0	0	1	0	0	0	5482	652	23	3	892	3	FAM13C	10	61028362	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	43859573	61028362	74506385	51	10558											
MUC6	4588	broad.mit.edu	37	chr11	1018137	1018137	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgtgggccacaggggttCtggtgcgtgtactagtgggg	4	11	20	6	1	1	0	0	0	1	0	1	0	1	0	1	7	2	2	1	7	2	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr11:1018137C>T	uc001lsw.2	-	31	4715	c.4664G>A	c.(4663-4665)AGA>AAA	p.R1555K		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1555	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CACAGGGGTTCTGGTGCGTGT	0.572													40	276					0	0	0	0	T	1018137	T	T	1018137	3	4	53	1	0	0	0	0	1	0	0	0	10033	913	32	2	2667	2	MUC6	11	1018137	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08		1018137	133988379	52	10559											
LRRC4C	57689	broad.mit.edu	37	chr11	40137212	40137212	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cggtgtgaggttagggatttCccgaaggttgcacatggcaa	9	10	15	7	2	0	1	0	1	0	0	1	3	1	2	1	5	1	4	1	5	3	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr11:40137212C>A	uc001mxa.1	-	2	2595	c.631G>T	c.(631-633)GAA>TAA	p.E211*	LRRC4C_uc001mxc.1_Nonsense_Mutation_p.E207*|LRRC4C_uc001mxd.1_Nonsense_Mutation_p.E207*|LRRC4C_uc001mxb.1_Nonsense_Mutation_p.E207*	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	211	LRR 6.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TTAGGGATTTCCCGAAGGTTG	0.453													31	98					8.88839e-20	1.057e-19	1	0	A	40137212	A	A	40137212	4	1	53	1	0	0	0	0	0	1	0	0	9058	864	30	2	1295	2	LRRC4C	11	40137212	Nonsense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	39119075	40137212	94869304	53	10560											
ALG9	79796	broad.mit.edu	37	chr11	111731328	111731328	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggctagcatcattcgactCacgtgcaacccaaacttctt	12	10	6	13	2	3	0	2	0	1	0	4	1	3	0	1	1	4	3	1	1	4	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr11:111731328C>T	uc001pmb.2	-	6	606	c.507G>A	c.(505-507)GTG>GTA	p.V169V	ALG9_uc001ply.2_5'UTR|ALG9_uc001plz.2_5'UTR|ALG9_uc010rwm.1_Silent_p.V169V|ALG9_uc010rwn.1_Silent_p.V123V|ALG9_uc010rwo.1_5'UTR|ALG9_uc009yyh.1_Silent_p.V64V	NM_001077690	NP_001071158	Q9H6U8	ALG9_HUMAN	asparagine-linked glycosylation 9 protein	169	Cytoplasmic (Potential).				dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			large_intestine(1)|ovary(1)	2		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		TCATTCGACTCACGTGCAACC	0.428													10	32					0	0	0	0	T	111731328	T	T	111731328	2	4	53	1	0	0	0	0	0	0	0	1	524	813	29	2		2	ALG9	11	111731328	Silent	SNP	C	TCGA-CN-4742-01A-02D-1512-08	71594116	111731328	23275188	54	10561											
ZBTB16	7704	broad.mit.edu	37	chr11	114121202	114121202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctccatgcagaagcacatGaagggccacaagcccgagga	13	4	11	13	1	0	2	0	1	0	1	2	4	2	3	4	2	3	2	4	2	3	0			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr11:114121202G>A	uc001pop.2	+	7	2211	c.1947G>A	c.(1945-1947)ATG>ATA	p.M649I	ZBTB16_uc001poq.2_Missense_Mutation_p.M649I	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	649	C2H2-type 9.				apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		AGAAGCACATGAAGGGCCACA	0.617													8	90					0	0	0	0	A	114121202	A	A	114121202	3	1	53	1	0	0	0	0	1	0	0	0	17593	1290	45	2	1969	2	ZBTB16	11	114121202	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	2389874	114121202	20885314	55	10562											
CD163L1	283316	broad.mit.edu	37	chr12	7586143	7586143	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatggcgaaagaaaatggaCatccaagctgtttgcacacg	15	7	10	9	2	0	1	0	0	0	1	1	3	1	2	1	2	2	3	1	2	4	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr12:7586143C>T	uc001qsy.2	-	3	298	c.272G>A	c.(271-273)TGT>TAT	p.C91Y	CD163L1_uc010sge.1_Missense_Mutation_p.C91Y	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	91	SRCR 1.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						AGAAAATGGACATCCAAGCTG	0.473													14	89					0	0	0	0	T	7586143	T	T	7586143	3	4	53	1	0	0	0	0	1	0	0	0	2983	478	17	4	4157	4	CD163L1	12	7586143	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08		7586143	126265752	56	10563											
RAB5B	5869	broad.mit.edu	37	chr12	56380870	56380870	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctggtattacgttttgtcaaAgggcagttccatgagtacca	10	13	10	8	1	1	1	1	1	0	0	2	1	2	1	2	2	2	5	2	2	4	6			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr12:56380870A>G	uc001siv.2	+	2	243	c.126A>G	c.(124-126)AAA>AAG	p.K42K	RAB5B_uc001siw.2_Silent_p.K42K|RAB5B_uc009zog.2_Missense_Mutation_p.K33R|RAB5B_uc010spz.1_Silent_p.K42K	NM_002868	NP_002859	P61020	RAB5B_HUMAN	RAB5B, member RAS oncogene family	42					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|membrane fraction|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			GTTTTGTCAAAGGGCAGTTCC	0.448													20	30					0	0	0	0	G	56380870	G	G	56380870	2	3	53	1	0	0	0	0	0	0	0	1	13014	69	3	5		5	RAB5B	12	56380870	Silent	SNP	A	TCGA-CN-4742-01A-02D-1512-08	48794727	56380870	77471025	57	10564											
NAV3	89795	broad.mit.edu	37	chr12	78598823	78598823	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcccagccttacttcagctgCgaccagaagatgttgggtat	9	10	11	11	1	1	2	1	0	0	2	1	3	1	2	3	1	4	3	3	1	3	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr12:78598823C>T	uc001syp.2	+	39	7116	c.6943C>T	c.(6943-6945)CGA>TGA	p.R2315*	NAV3_uc001syo.2_Nonsense_Mutation_p.R2293*|NAV3_uc010sub.1_Nonsense_Mutation_p.R1772*|NAV3_uc009zsf.2_Nonsense_Mutation_p.R1124*	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2315						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACTTCAGCTGCGACCAGAAGA	0.512										HNSCC(70;0.22)			10	34					0	0	0	0	T	78598823	T	T	78598823	4	4	53	1	0	0	0	0	0	1	0	0	10238	760	27	1	7027	1	NAV3	12	78598823	Nonsense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	22217953	78598823	55253072	58	10565											
CCDC38	120935	broad.mit.edu	37	chr12	96288830	96288830	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcctgtgctctttttagtgCttgctggatttgccaatgtt	4	19	10	8	0	1	0	0	0	1	0	1	1	1	1	2	1	5	4	2	1	2	6			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr12:96288830C>A	uc001tek.1	-	8	943	c.709G>T	c.(709-711)GCA>TCA	p.A237S		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	237										skin(1)	1						CTTTTTAGTGCTTGCTGGATT	0.333													19	200					2.5808e-16	3.04165e-16	1	0	A	96288830	A	A	96288830	3	1	53	1	0	0	0	0	1	0	0	0	2823	797	28	4	1018	4	CCDC38	12	96288830	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	17690007	96288830	37563065	59	10566											
TMEM132D	121256	broad.mit.edu	37	chr12	130184666	130184666	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctccacgggggtcccctcCggctggtccacggacttcct	4	8	12	17	3	0	0	0	0	0	0	5	1	5	1	6	5	1	2	6	5	0	1	rs143084996	byFrequency	TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr12:130184666C>T	uc009zyl.1	-	2	985	c.657G>A	c.(655-657)CCG>CCA	p.P219P		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	219	Extracellular (Potential).					integral to membrane		p.P219L(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGGTCCCCTCCGGCTGGTCCA	0.682													11	86					0	0	0	0	T	130184666	T	T	130184666	2	4	53	1	0	0	0	0	0	0	0	1	16113	639	23	1		1	TMEM132D	12	130184666	Silent	SNP	C	TCGA-CN-4742-01A-02D-1512-08	33895836	130184666	3667229	60	10567											
FREM2	341640	broad.mit.edu	37	chr13	39266304	39266304	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatcagctacaaacatgatgGcactgagtcaagtgaagata	17	8	9	7	0	2	4	2	3	0	1	2	4	2	4	0	1	3	2	0	1	6	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr13:39266304G>C	uc001uwv.2	+	1	5132	c.4823G>C	c.(4822-4824)GGC>GCC	p.G1608A		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1608	Extracellular (Potential).|CSPG 11.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AAACATGATGGCACTGAGTCA	0.423													13	119					0	0	0	0	C	39266304	C	C	39266304	3	2	53	1	0	0	0	0	1	0	0	0	6079	1203	42	4	4825	4	FREM2	13	39266304	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08		39266304	75903574	61	10568											
RBM26	64062	broad.mit.edu	37	chr13	79943084	79943091	+	Frame_Shift_Del	DEL	CTGTTCTA	-	-																															ataattattttctaatggatCtgttctatccaggtcatatt																										TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr13:79943084_79943091delCTGTTCTA	uc001vkz.2	-	6	683_690	c.669_676delTAGAACAG	c.(667-678)GATAGAACAGATfs	p.D223fs	RBM26_uc001vky.2_Frame_Shift_Del_p.D223fs|RBM26_uc001vla.2_Frame_Shift_Del_p.D223fs|RBM26_uc001vkx.2_5'UTR|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	223_226					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TCTAATGGATCTGTTCTATCCAGGTCAT	0.351													---	---	---								-	79943091	-	-	79943084	7	5	53	1	0	1	0	1	0	0	0	0	13191	913	32	0	2330	0	RBM26	13	79943084	Frame_Shift_Del	DEL	CTGTTCTA	TCGA-CN-4742-01A-02D-1512-08	40676780	79943084	35226794	62	10569											
TOX4	9878	broad.mit.edu	37	chr14	21961325	21961325	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgtggaaagtagtcctgAgcggcctatgaacaacagcc	13	7	11	10	1	0	2	0	2	0	0	1	3	1	3	3	2	5	1	3	2	6	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr14:21961325A>C	uc001waz.2	+	7	1653	c.1550A>C	c.(1549-1551)GAG>GCG	p.E517A	TOX4_uc001way.2_Missense_Mutation_p.E387A|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Missense_Mutation_p.E494A|TOX4_uc010tlv.1_Missense_Mutation_p.E387A	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	517	Gln/Pro-rich.					chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding	p.E517Q(1)		ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		AGTAGTCCTGAGCGGCCTATG	0.507													13	93					0	0	0	0	C	21961325	C	C	21961325	3	2	53	1	0	0	0	0	1	0	0	0	16447	304	11	5	1576	5	TOX4	14	21961325	Missense_Mutation	SNP	A	TCGA-CN-4742-01A-02D-1512-08		21961325	85388215	63	10570											
RPS6KL1	83694	broad.mit.edu	37	chr14	75376459	75376459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagccccctagcaccgggcCggccccctcaggaacccaag	9	2	10	20	2	1	0	1	0	0	0	1	1	1	1	7	3	3	1	7	3	3	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr14:75376459C>T	uc010tux.1	-	7	1585	c.1057G>A	c.(1057-1059)GGC>AGC	p.G353S	RPS6KL1_uc001xqx.1_Missense_Mutation_p.G105S|RPS6KL1_uc001xqw.2_Missense_Mutation_p.G322S|RPS6KL1_uc010asd.1_RNA	NM_031464	NP_113652	Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	353	Protein kinase.					ribosome	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00658)		AGCACCGGGCCGGCCCCCTCA	0.692													9	37					0	0	0	0	T	75376459	T	T	75376459	3	4	53	1	0	0	0	0	1	0	0	0	13724	652	23	1	685	1	RPS6KL1	14	75376459	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	53415134	75376459	31973081	64	10571											
CDAN1	146059	broad.mit.edu	37	chr15	43023936	43023936	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctgtaggcgccacaaccGccccagcttgtcagctccca	7	8	8	18	2	1	0	1	0	0	0	3	0	3	0	6	1	3	3	6	1	2	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr15:43023936G>A	uc001zql.2	-	11	1738	c.1621C>T	c.(1621-1623)CGG>TGG	p.R541W	CDAN1_uc001zqj.2_5'Flank|CDAN1_uc001zqk.2_5'UTR	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	541						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CGCCACAACCGCCCCAGCTTG	0.627													4	97					0	0	0	0	A	43023936	A	A	43023936	3	1	53	1	0	0	0	0	1	0	0	0	3069	1086	38	1	2134	1	CDAN1	15	43023936	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08		43023936	59507456	65	10572											
ZSCAN29	146050	broad.mit.edu	37	chr15	43658711	43658712	+	Frame_Shift_Ins	INS	-	T	T																															catacacttggctgttcctaINStggcagtttctgagagcctc																										TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr15:43658711_43658712insT	uc001zrk.1	-	3	965_966	c.818_819insA	c.(817-819)CATfs	p.H273fs	ZSCAN29_uc001zrj.1_Frame_Shift_Ins_p.H153fs|ZSCAN29_uc010bdf.1_Frame_Shift_Ins_p.H272fs|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Intron|ZSCAN29_uc001zrm.2_Frame_Shift_Ins_p.H272fs	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	273					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		GGCTGTTCCTATGGCAGTTTCT	0.545													---	---	---								T	43658712	T	T	43658711	7	5	53	1	0	1	1	0	0	0	0	0	18303	446	16	0	1751	0	ZSCAN29	15	43658711	Frame_Shift_Ins	INS	-	TCGA-CN-4742-01A-02D-1512-08	634775	43658711	58872681	66	10573											
C16orf90	646174	broad.mit.edu	37	chr16	3546873	3546874	+	5'Flank	INS	-	T	T																															atttttctttttttcttttcINStttttttttttttttaagat																										TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr16:3546873_3546874insT	uc002cvi.2	-							NM_001080524	NP_001073993	A8MZG2	CP090_HUMAN	hypothetical protein LOC646174												0						tttttcttttcttttttttttt	0.124													---	---	---								T	3546874	T	T	3546873	6	5	53	0	1	1	1	0	0	0	0	0	1849	928	32	0		0	C16orf90	16	3546873	5'Flank	INS	-	TCGA-CN-4742-01A-02D-1512-08		3546873	86807880	67	10574											
PDXDC1	23042	broad.mit.edu	37	chr16	15122790	15122790	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acaccttcaggagtcggccgGgagaggcactcgtgtgacgc	8	6	15	12	4	1	2	1	1	0	1	3	4	1	3	2	4	0	1	2	4	0	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr16:15122790G>A	uc002dda.3	+	15	1484	c.1260G>A	c.(1258-1260)CGG>CGA	p.R420R	PDXDC1_uc010uzl.1_Silent_p.R405R|PDXDC1_uc010uzm.1_Silent_p.R329R|PDXDC1_uc002dcz.2_Silent_p.R397R|PDXDC1_uc002ddb.3_Silent_p.R393R|PDXDC1_uc010uzn.1_Silent_p.R392R|PDXDC1_uc002ddc.2_Silent_p.R420R	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	420					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GAGTCGGCCGGGAGAGGCACT	0.582													4	60					0	0	0	0	A	15122790	A	A	15122790	2	1	53	1	0	0	0	0	0	0	0	1	11750	1219	43	4		4	PDXDC1	16	15122790	Silent	SNP	G	TCGA-CN-4742-01A-02D-1512-08	11575917	15122790	75231963	68	10575											
XYLT1	64131	broad.mit.edu	37	chr16	17353318	17353318	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tctcgttgttgctgtctgttCgcactttctctttcggccga	2	18	9	12	4	3	0	0	0	3	0	7	1	3	0	1	1	1	5	1	1	0	5	rs150531859	byFrequency	TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr16:17353318C>G	uc002dfa.2	-	3	525	c.440G>C	c.(439-441)CGA>CCA	p.R147P		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	147	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GCTGTCTGTTCGCACTTTCTC	0.463													15	83					0	0	0	0	G	17353318	G	G	17353318	3	3	53	1	0	0	0	0	1	0	0	0	17531	884	31	3	2479	3	XYLT1	16	17353318	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	2230528	17353318	73001435	69	10576											
NETO2	81831	broad.mit.edu	37	chr16	47117173	47117173	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttgtgcagaatcttctcGccccctgacataaatttcac	9	13	6	13	1	3	2	1	1	2	1	4	2	3	2	2	0	2	2	2	0	3	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr16:47117173G>A	uc002eer.1	-	9	1922	c.1537C>T	c.(1537-1539)CGA>TGA	p.R513*	NETO2_uc002eeq.1_Nonsense_Mutation_p.R248*|NETO2_uc010vgf.1_Nonsense_Mutation_p.R370*	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	513	Cytoplasmic (Potential).					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				GAATCTTCTCGCCCCCTGACA	0.478										HNSCC(25;0.065)			16	143					0	0	0	0	A	47117173	A	A	47117173	4	1	53	1	0	0	0	0	0	1	0	0	10394	1095	38	1	44	1	NETO2	16	47117173	Nonsense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	29763855	47117173	43237580	70	10577											
NAE1	8883	broad.mit.edu	37	chr16	66850564	66850564	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctggagccccattttcatTttttagaattcctattgtaa	9	19	5	8	0	2	1	1	0	1	1	3	2	3	2	3	1	1	1	3	1	4	10			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr16:66850564T>A	uc002eqf.2	-	11	837	c.760A>T	c.(760-762)AAT>TAT	p.N254Y	NAE1_uc002eqe.2_Missense_Mutation_p.N248Y|NAE1_uc002eqg.2_Missense_Mutation_p.N165Y|NAE1_uc010cdv.2_Missense_Mutation_p.N257Y|NAE1_uc010cdw.1_3'UTR	NM_003905	NP_003896	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform a	254					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	CCATTTTCATTTTTTAGAATT	0.353													5	49					0	0	0	0	A	66850564	A	A	66850564	3	1	53	1	0	0	0	0	1	0	0	0	10192	1841	64	5	884	5	NAE1	16	66850564	Missense_Mutation	SNP	T	TCGA-CN-4742-01A-02D-1512-08	19733391	66850564	23504189	71	10578											
DHX33	56919	broad.mit.edu	37	chr17	5357158	5357158	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacctctggatctctggcacGgtcatcttatcaaacttctc	8	14	6	13	1	6	0	2	0	4	0	8	1	6	1	1	3	2	1	1	3	3	3	rs147168886	byFrequency	TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr17:5357158G>A	uc002gca.2	-	7	1292	c.1290C>T	c.(1288-1290)ACC>ACT	p.T430T	DHX33_uc002gbz.2_Silent_p.T201T|DHX33_uc002gcb.2_Silent_p.T257T|DHX33_uc010clf.2_Silent_p.T206T	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	430	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						TCTCTGGCACGGTCATCTTAT	0.562													18	26					0	0	0	0	A	5357158	A	A	5357158	2	1	53	1	0	0	0	0	0	0	0	1	4528	1103	39	1		1	DHX33	17	5357158	Silent	SNP	G	TCGA-CN-4742-01A-02D-1512-08		5357158	75838052	72	10579											
TP53	7157	broad.mit.edu	37	chr17	7577058	7577058	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggcagctcgtggtgaggctCccctttcttgcggagattct	4	12	14	11	2	2	2	0	1	2	1	4	3	3	2	2	4	2	3	2	4	0	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr17:7577058C>A	uc002gim.2	-	8	1074	c.880G>T	c.(880-882)GAG>TAG	p.E294*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E294*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E162*|TP53_uc010cng.1_Nonsense_Mutation_p.E162*|TP53_uc002gii.1_Nonsense_Mutation_p.E162*|TP53_uc010cnh.1_Nonsense_Mutation_p.E294*|TP53_uc010cni.1_Nonsense_Mutation_p.E294*|TP53_uc002gij.2_Nonsense_Mutation_p.E294*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	294	Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E294*(35)|p.E294fs*51(14)|p.K291fs*48(8)|p.0?(7)|p.E294E(4)|p.E294K(3)|p.E294fs*12(3)|p.?(2)|p.E294Q(2)|p.E294G(2)|p.E294D(2)|p.L265_K305del41(1)|p.E294>*(1)|p.G293fs*1(1)|p.R290fs*50(1)|p.R290_P295>X(1)|p.E294fs*11(1)|p.E294V(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGTGAGGCTCCCCTTTCTTG	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	57					1.10513e-12	1.27963e-12	1	0	A	7577058	A	A	7577058	4	1	53	1	0	0	0	0	0	1	0	0	16448	864	30	2	406	2	TP53	17	7577058	Nonsense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	2219900	7577058	73618152	73	10580											
CDK5R1	8851	broad.mit.edu	37	chr17	30815310	30815310	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggatcacgagctccaggcCgtcctgctgacatgcctgta	7	9	11	14	3	1	1	1	1	0	0	4	3	3	2	4	2	3	3	4	2	1	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr17:30815310C>T	uc002hhn.2	+	2	893	c.672C>T	c.(670-672)GCC>GCT	p.A224A	CDK5R1_uc010wca.1_Silent_p.A224A|CDK5R1_uc010ctc.2_5'UTR	NM_003885	NP_003876	Q15078	CD5R1_HUMAN	cyclin-dependent kinase 5, regulatory subunit 1	224					axon guidance|axonal fasciculation|brain development|cell proliferation|embryo development|ionotropic glutamate receptor signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of transcription, DNA-dependent|neuron cell-cell adhesion|neuron migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of neuron apoptosis|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation	axon|contractile fiber|cyclin-dependent protein kinase 5 holoenzyme complex|cytosol|dendritic spine|growth cone|neuromuscular junction|neuronal cell body|perinuclear region of cytoplasm|plasma membrane	cadherin binding|calcium ion binding|protein kinase binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.0938)			AGCTCCAGGCCGTCCTGCTGA	0.592													36	209					0	0	0	0	T	30815310	T	T	30815310	2	4	53	1	0	0	0	0	0	0	0	1	3158	639	23	1		1	CDK5R1	17	30815310	Silent	SNP	C	TCGA-CN-4742-01A-02D-1512-08	23238252	30815310	50379900	74	10581											
TBKBP1	9755	broad.mit.edu	37	chr17	45777021	45777021	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggatctggcctccaaccagtCggagcgagacatggcgtggg	8	6	16	11	3	1	1	0	0	1	1	3	4	2	3	3	5	2	0	3	5	1	0			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr17:45777021C>T	uc002ilu.2	+	6	1679	c.830C>T	c.(829-831)TCG>TTG	p.S277L		NM_014726	NP_055541	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	277					innate immune response						0						TCCAACCAGTCGGAGCGAGAC	0.572											OREG0024498	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	197					0	0	0	0	T	45777021	T	T	45777021	3	4	53	1	0	0	0	0	1	0	0	0	15704	893	31	1	852	1	TBKBP1	17	45777021	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	14961711	45777021	35418189	75	10582											
INTS2	57508	broad.mit.edu	37	chr17	59946709	59946709	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcatagatggaatacctgcGaccgtcagaggcaaaagttc	13	8	11	9	2	1	2	1	0	0	2	2	4	1	3	2	2	3	3	2	2	5	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr17:59946709G>A	uc002izn.2	-	22	3163	c.3087C>T	c.(3085-3087)GTC>GTT	p.V1029V	INTS2_uc002izm.2_Silent_p.V1021V	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	1029					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						GAATACCTGCGACCGTCAGAG	0.333													7	19					0	0	0	0	A	59946709	A	A	59946709	2	1	53	1	0	0	0	0	0	0	0	1	7817	1045	37	1		1	INTS2	17	59946709	Silent	SNP	G	TCGA-CN-4742-01A-02D-1512-08	14169688	59946709	21248501	76	10583											
AXIN2	8313	broad.mit.edu	37	chr17	63554134	63554134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctgtgttttctcccccaCtcctcacatattcgaggtat	8	14	6	13	1	2	0	1	0	1	0	5	1	3	0	3	1	1	3	3	1	3	5			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr17:63554134C>T	uc002jfi.2	-	2	894	c.605G>A	c.(604-606)AGT>AAT	p.S202N	AXIN2_uc010den.1_Missense_Mutation_p.S202N|AXIN2_uc002jfh.2_Missense_Mutation_p.S202N|AXIN2_uc002jfj.1_Missense_Mutation_p.S202N	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	202					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						TTCTCCCCCACTCCTCACATA	0.488									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				44	58					0	0	0	0	T	63554134	T	T	63554134	3	4	53	1	0	0	0	0	1	0	0	0	1239	565	20	4	1966	4	AXIN2	17	63554134	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	3607425	63554134	17641076	77	10584											
LAMA1	284217	broad.mit.edu	37	chr18	6973160	6973160	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttttgttggtgacttttGatttgagctcatttccttta	5	23	8	5	0	1	3	1	3	0	0	2	3	2	3	1	1	1	3	1	1	1	9			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr18:6973160G>T	uc002knm.2	-	47	6764	c.6670C>A	c.(6670-6672)CAA>AAA	p.Q2224K	LAMA1_uc010wzj.1_Missense_Mutation_p.Q1700K	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2224	Laminin G-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGACTTTTGATTTGAGCTC	0.378													40	73					2.6416e-12	3.0321e-12	1	0	T	6973160	T	T	6973160	3	4	53	1	0	0	0	0	1	0	0	0	8645	1299	45	2	2625	2	LAMA1	18	6973160	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08		6973160	71104088	78	10585											
MUC16	94025	broad.mit.edu	37	chr19	9064691	9064691	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcagggcctgacatggaTgttctgctaaaggagatggc	9	10	14	8	0	2	2	1	1	1	1	2	4	2	3	1	4	2	3	1	4	2	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr19:9064691T>A	uc002mkp.2	-	3	22959	c.22755A>T	c.(22753-22755)ACA>ACT	p.T7585T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7587	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGACATGGATGTTCTGCTAA	0.488													16	89					0	0	0	0	A	9064691	A	A	9064691	2	1	53	1	0	0	0	0	0	0	0	1	10026	1451	51	5		5	MUC16	19	9064691	Silent	SNP	T	TCGA-CN-4742-01A-02D-1512-08		9064691	50064292	79	10586											
KEAP1	9817	broad.mit.edu	37	chr19	10602732	10602732	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgcacttctgcagctgcatCtgcaggaagttcggcgtcaa	8	10	11	12	3	3	0	1	0	2	0	5	1	3	1	0	2	4	6	0	2	2	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr19:10602732C>T	uc002moq.1	-	3	1002	c.846G>A	c.(844-846)CAG>CAA	p.Q282Q	KEAP1_uc002mop.1_5'UTR|KEAP1_uc002mor.1_Silent_p.Q282Q	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	282	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GCAGCTGCATCTGCAGGAAGT	0.617													12	72					0	0	0	0	T	10602732	T	T	10602732	2	4	53	1	0	0	0	0	0	0	0	1	8180	912	32	2		2	KEAP1	19	10602732	Silent	SNP	C	TCGA-CN-4742-01A-02D-1512-08	1538041	10602732	48526251	80	10587											
ZNF527	84503	broad.mit.edu	37	chr19	37880352	37880352	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagagaattcataccggagaAaagccctatgaatgcatcaa	17	7	8	9	1	2	3	2	1	0	2	2	5	2	3	2	1	3	1	2	1	7	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr19:37880352A>G	uc010efk.1	+	5	1512	c.1401A>G	c.(1399-1401)GAA>GAG	p.E467E	ZNF527_uc002ogf.3_Silent_p.E435E|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATACCGGAGAAAAGCCCTATG	0.413													5	64					0	0	0	0	G	37880352	G	G	37880352	2	3	53	1	0	0	0	0	0	0	0	1	18035	11	1	5		5	ZNF527	19	37880352	Silent	SNP	A	TCGA-CN-4742-01A-02D-1512-08	27277620	37880352	21248631	81	10588											
OXT	5020	broad.mit.edu	37	chr20	3052920	3052920	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtcttgggcctctgctgcagCccgggtgagcggggcaaggc	4	7	18	12	2	2	1	0	1	2	0	2	1	2	1	2	5	4	3	2	5	1	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr20:3052920C>T	uc002wht.1	+	2	354	c.318C>T	c.(316-318)AGC>AGT	p.S106S		NM_000915	NP_000906	P01178	NEU1_HUMAN	oxytocin-neurophysin I preproprotein	106					signal transduction		neurohypophyseal hormone activity				0					Oxytocin(DB00107)	TCTGCTGCAGCCCGGGTGAGC	0.751													3	26					0	0	0	0	T	3052920	T	T	3052920	2	4	53	1	0	0	0	0	0	0	0	1	11391	738	26	4		4	OXT	20	3052920	Silent	SNP	C	TCGA-CN-4742-01A-02D-1512-08		3052920	59972600	82	10589											
C20orf26	26074	broad.mit.edu	37	chr20	20177407	20177407	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctaccgtgtttacccaaaatCcagagaaggcaaggtaagag	15	7	10	9	1	0	2	0	0	0	2	1	3	1	2	3	2	2	3	3	2	7	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr20:20177407C>T	uc002wru.2	+	16	1860	c.1784C>T	c.(1783-1785)TCC>TTC	p.S595F	C20orf26_uc010zse.1_Missense_Mutation_p.S575F	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	595										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		TACCCAAAATCCAGAGAAGGC	0.468													9	91					0	0	0	0	T	20177407	T	T	20177407	3	4	53	1	0	0	0	0	1	0	0	0	2116	855	30	2	1874	2	C20orf26	20	20177407	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	17124487	20177407	42848113	83	10590											
THAP7	80764	broad.mit.edu	37	chr22	21355011	21355011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctttggtcttggttgtcCggcgcaacttggagaaagac	7	12	13	9	2	1	2	0	0	1	2	3	3	3	2	2	4	1	2	2	4	2	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr22:21355011C>T	uc002ztr.1	-	4	332	c.302G>A	c.(301-303)CGG>CAG	p.R101Q	THAP7_uc002zts.1_Missense_Mutation_p.R101Q|FLJ39582_uc002ztt.1_5'Flank|FLJ39582_uc002ztu.1_5'Flank|FLJ39582_uc002ztv.2_5'Flank	NM_001008695	NP_001008695	Q9BT49	THAP7_HUMAN	THAP domain containing 7 isoform 2	101					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding				0	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CTTGGTTGTCCGGCGCAACTT	0.572													5	255					0	0	0	0	T	21355011	T	T	21355011	3	4	53	1	0	0	0	0	1	0	0	0	15915	652	23	1	635	1	THAP7	22	21355011	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08		21355011	29949555	84	10591											
ZNF280A	129025	broad.mit.edu	37	chr22	22869403	22869403	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtacccctgggattccatcCctgagtttaacccttttgga	7	13	9	12	0	0	1	0	1	0	0	2	3	2	3	5	3	2	2	5	3	2	6			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr22:22869403C>G	uc002zwe.2	-	2	805	c.552G>C	c.(550-552)AGG>AGC	p.R184S	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GGATTCCATCCCTGAGTTTAA	0.448													19	165					0	0	0	0	G	22869403	G	G	22869403	3	3	53	1	0	0	0	0	1	0	0	0	17881	622	22	4	1080	4	ZNF280A	22	22869403	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	1514392	22869403	28435163	85	10592											
HPS4	89781	broad.mit.edu	37	chr22	26849287	26849287	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctgagggtttgggaagccgGagctccgtgctgcaggtgcc	5	8	17	11	2	0	1	0	1	0	0	1	3	1	3	4	4	5	4	4	4	1	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr22:26849287G>A	uc003acl.2	-	14	2698	c.2039C>T	c.(2038-2040)TCC>TTC	p.S680F	HPS4_uc003aci.2_Missense_Mutation_p.S675F|HPS4_uc003acj.2_Missense_Mutation_p.S544F|HPS4_uc003ack.2_Missense_Mutation_p.S471F|HPS4_uc003acn.2_Missense_Mutation_p.S526F|HPS4_uc003ach.2_Missense_Mutation_p.S415F	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	680					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						TGGGAAGCCGGAGCTCCGTGC	0.582									Hermansky-Pudlak_syndrome				7	268					0	0	0	0	A	26849287	A	A	26849287	3	1	53	1	0	0	0	0	1	0	0	0	7380	1174	41	2	91	2	HPS4	22	26849287	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	3979884	26849287	24455279	86	10593											
AP1B1	162	broad.mit.edu	37	chr22	29730294	29730294	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcaaagtcggtcatgacctGcaaggccttgttggtcagct	8	10	13	10	1	2	1	2	1	0	0	3	1	2	1	2	4	2	4	2	4	2	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chr22:29730294G>A	uc003afj.2	-	17	2453	c.2269C>T	c.(2269-2271)CAG>TAG	p.Q757*	AP1B1_uc003afi.2_Nonsense_Mutation_p.Q750*|AP1B1_uc003afk.2_Nonsense_Mutation_p.Q750*|AP1B1_uc003afl.2_Nonsense_Mutation_p.Q730*|AP1B1_uc003afh.2_5'Flank|AP1B1_uc011ako.1_Nonsense_Mutation_p.Q310*|SNORD125_uc010gvn.1_5'Flank	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	757					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GTCATGACCTGCAAGGCCTTG	0.607													4	130					0	0	0	0	A	29730294	A	A	29730294	4	1	53	1	0	0	0	0	0	1	0	0	731	1328	46	4	608	4	AP1B1	22	29730294	Nonsense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	2881007	29730294	21574272	87	10594											
SRPX	8406	broad.mit.edu	37	chrX	38079976	38079978	+	In_Frame_Del	DEL	GCA	-	-																															gctgcggctgggcgggacgcGcagcagcagcagcagcagca																								rs72249350		TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:38079976_38079978delGCA	uc004ddy.1	-	1	154_156	c.68_70delTGC	c.(67-72)CTGCGC>CGC	p.L23del	SRPX_uc004ddz.1_In_Frame_Del_p.L23del|SRPX_uc011mkh.1_In_Frame_Del_p.L23del|SRPX_uc011mki.1_In_Frame_Del_p.L23del	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	23			Missing.		cell adhesion	cell surface|membrane					0						GGCGGGACGCgcagcagcagcag	0.576											OREG0019726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	38079978	-	-	38079976	7	5	53	1	0	1	0	1	0	0	0	0	15230	1087	38	0	1364	0	SRPX	23	38079976	In_Frame_Del	DEL	GCA	TCGA-CN-4742-01A-02D-1512-08		38079976	117190584	88	10595											
USP9X	8239	broad.mit.edu	37	chrX	41007737	41007737	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaagtgttgaaccttctgtGgaatctggctcacagtgatg	10	12	11	8	0	3	2	1	2	2	0	3	3	3	3	1	2	1	2	1	2	3	2			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:41007737G>T	uc004dfb.2	+	12	2168	c.1535G>T	c.(1534-1536)TGG>TTG	p.W512L	USP9X_uc004dfc.2_Missense_Mutation_p.W512L	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	512					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						AACCTTCTGTGGAATCTGGCT	0.448													20	140					1.96292e-10	2.23367e-10	1	0	T	41007737	T	T	41007737	3	4	53	1	0	0	0	0	1	0	0	0	17158	1357	47	4	1577	4	USP9X	23	41007737	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	2927761	41007737	114262823	89	10596											
ATRX	546	broad.mit.edu	37	chrX	76872192	76872192	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgttaatgctgtataatCtttcctctgtaattaacaag	11	19	5	6	0	2	0	0	0	2	0	3	0	3	0	1	0	2	4	1	0	6	8			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:76872192C>G	uc004ecp.3	-	22	5687	c.5455G>C	c.(5455-5457)GAT>CAT	p.D1819H	ATRX_uc004ecq.3_Missense_Mutation_p.D1781H|ATRX_uc004eco.3_Missense_Mutation_p.D1604H	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1819					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GCTGTATAATCTTTCCTCTGT	0.303			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						26	108					0	0	0	0	G	76872192	G	G	76872192	3	3	53	1	0	0	0	0	1	0	0	0	1210	913	32	2	2079	2	ATRX	23	76872192	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	35864455	76872192	78398368	90	10597											
CHM	1121	broad.mit.edu	37	chrX	85119736	85119736	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctgaagcctctggctgtaAactgtctccatcaaggataa	11	12	8	10	0	4	1	1	1	3	0	5	2	4	2	2	2	2	2	2	2	5	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:85119736A>T	uc004eet.2	-	15	1891	c.1861T>A	c.(1861-1863)TTA>ATA	p.L621I	CHM_uc011mqz.1_Missense_Mutation_p.L473I	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	621					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				TCTGGCTGTAAACTGTCTCCA	0.478													8	34					0	0	0	0	T	85119736	T	T	85119736	3	4	53	1	0	0	0	0	1	0	0	0	3365	11	1	5	104	5	CHM	23	85119736	Missense_Mutation	SNP	A	TCGA-CN-4742-01A-02D-1512-08	8247544	85119736	70150824	91	10598											
PCDH11X	27328	broad.mit.edu	37	chrX	91132915	91132915	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caatgtcacagtctttgtaaGcattattgatcagaatgaca	14	13	7	7	0	3	3	2	2	1	1	3	3	3	3	0	0	1	2	0	0	4	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:91132915G>C	uc004efk.1	+	2	2521	c.1676G>C	c.(1675-1677)AGC>ACC	p.S559T	PCDH11X_uc004efl.1_Missense_Mutation_p.S559T|PCDH11X_uc004efo.1_Missense_Mutation_p.S559T|PCDH11X_uc010nmv.1_Missense_Mutation_p.S559T|PCDH11X_uc004efm.1_Missense_Mutation_p.S559T|PCDH11X_uc004efn.1_Missense_Mutation_p.S559T|PCDH11X_uc004efh.1_Missense_Mutation_p.S559T|PCDH11X_uc004efj.1_Missense_Mutation_p.S559T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	559	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GTCTTTGTAAGCATTATTGAT	0.373													33	165					0	0	0	0	C	91132915	C	C	91132915	3	2	53	1	0	0	0	0	1	0	0	0	11562	971	34	4	1682	4	PCDH11X	23	91132915	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	6013179	91132915	64137645	92	10599											
SRPX2	27286	broad.mit.edu	37	chrX	99917202	99917202	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgttatacattaaatatcCaggatggagaagccacatgc	14	10	10	7	0	0	1	0	0	0	1	1	3	1	2	2	3	3	1	2	3	6	4			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:99917202C>T	uc004egb.2	+	4	673	c.193C>T	c.(193-195)CAG>TAG	p.Q65*		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	65					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						ATTAAATATCCAGGATGGAGA	0.398													25	101					0	0	0	0	T	99917202	T	T	99917202	4	4	53	1	0	0	0	0	0	1	0	0	15231	595	21	4	203	4	SRPX2	23	99917202	Nonsense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	8784287	99917202	55353358	93	10600											
AMOT	154796	broad.mit.edu	37	chrX	112058641	112058641	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaactcttgcctcaagttcCggttctcgtctgagaggatc	7	12	9	13	2	4	1	1	1	3	1	7	3	5	2	3	2	2	2	3	2	2	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:112058641C>T	uc004epr.2	-	2	1337	c.1337G>A	c.(1336-1338)CGG>CAG	p.R446Q	AMOT_uc004eps.2_Missense_Mutation_p.R37Q|AMOT_uc004ept.1_Missense_Mutation_p.R446Q	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	446	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						CCTCAAGTTCCGGTTCTCGTC	0.498													75	316					0	0	0	0	T	112058641	T	T	112058641	3	4	53	1	0	0	0	0	1	0	0	0	582	652	23	1	1957	1	AMOT	23	112058641	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	12141439	112058641	43211919	94	10601											
USP26	83844	broad.mit.edu	37	chrX	132159533	132159533	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cttctgaagggtctcctctaCctccttgctattaagctggg	6	14	9	12	0	3	1	0	1	3	0	5	1	4	1	3	2	3	2	3	2	4	5			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:132159533C>A	uc010nrm.1	-	6	3186	c.2716G>T	c.(2716-2718)GTA>TTA	p.V906L	USP26_uc011mvf.1_Missense_Mutation_p.V906L	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	906					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					GTCTCCTCTACCTCCTTGCTA	0.448													18	99					1.67942e-08	1.87867e-08	1	0	A	132159533	A	A	132159533	3	1	53	1	0	0	0	0	1	0	0	0	17125	507	18	4	28	4	USP26	23	132159533	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	20100892	132159533	23111027	95	10602											
CXorf48	54967	broad.mit.edu	37	chrX	134305097	134305097	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctcagaagcctgagcatcGtcccagttgtcaccaccggc	8	8	10	15	2	2	2	2	1	1	1	5	2	3	2	4	1	2	2	4	1	1	1			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:134305097G>A	uc004eyk.1	-	1	655	c.-1C>T	c.(-3-1)GACGA>GATGA		CXorf48_uc004eyl.1_Translation_Start_Site	NM_001031705	NP_001026875	Q8WUE5	CX048_HUMAN	hypothetical protein LOC54967 isoform 1												0	Acute lymphoblastic leukemia(192;0.000127)					CCTGAGCATCGTCCCAGTTGT	0.632													15	104					0	0	0	0	A	134305097	A	A	134305097	1	1	53	1	0	0	0	0	0	0	0	0	4128	1160	40	1		1	CXorf48	23	134305097	Translation_Start_Site	SNP	G	TCGA-CN-4742-01A-02D-1512-08	2145564	134305097	20965463	96	10603											
SLC9A6	10479	broad.mit.edu	37	chrX	135098865	135098865	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctacatggggctgacacTgttcaccttccagaaccatg	9	10	8	14	0	1	2	1	1	0	1	3	2	3	2	4	2	2	2	4	2	2	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:135098865T>A	uc004ezj.2	+	10	1278	c.1202T>A	c.(1201-1203)CTG>CAG	p.L401Q	SLC9A6_uc004ezk.2_Missense_Mutation_p.L433Q	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	401	Helical; (Potential).				regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GGGCTGACACTGTTCACCTTC	0.333													8	119					0	0	0	0	A	135098865	A	A	135098865	3	1	53	1	0	0	0	0	1	0	0	0	14782	1580	55	5	1336	5	SLC9A6	23	135098865	Missense_Mutation	SNP	T	TCGA-CN-4742-01A-02D-1512-08	793768	135098865	20171695	97	10604											
MAGEC1	9947	broad.mit.edu	37	chrX	140995932	140995932	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggatgaaaaggtggacgaGttggcgcggtttcttctcct	7	12	14	8	3	2	1	0	1	2	0	3	4	2	3	1	5	0	2	1	5	2	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:140995932G>C	uc004fbt.2	+	4	3028	c.2742G>C	c.(2740-2742)GAG>GAC	p.E914D	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	914	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTGGACGAGTTGGCGCGGT	0.493										HNSCC(15;0.026)			30	321					0	0	0	0	C	140995932	C	C	140995932	3	2	53	1	0	0	0	0	1	0	0	0	9233	1020	36	4	2748	4	MAGEC1	23	140995932	Missense_Mutation	SNP	G	TCGA-CN-4742-01A-02D-1512-08	5897067	140995932	14274628	98	10605											
L1CAM	3897	broad.mit.edu	37	chrX	153130403	153130403	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggttgtgtgtccgaagttcGgggtcccgaaggttgaagga	8	10	17	6	3	0	1	0	1	0	0	3	4	2	2	2	5	0	3	2	5	3	3			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:153130403G>A	uc004fjb.2	-	22	3027	c.2919C>T	c.(2917-2919)CCC>CCT	p.P973P	L1CAM_uc004fjc.2_Silent_p.P973P|L1CAM_uc010nuo.2_Silent_p.P968P	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	973	Extracellular (Potential).|Fibronectin type-III 4.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCGAAGTTCGGGGTCCCGAA	0.642													44	281					0	0	0	0	A	153130403	A	A	153130403	2	1	53	1	0	0	0	0	0	0	0	1	8628	1103	39	1		1	L1CAM	23	153130403	Silent	SNP	G	TCGA-CN-4742-01A-02D-1512-08	12134471	153130403	2140157	99	10606											
PLXNA3	55558	broad.mit.edu	37	chrX	153698457	153698457	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaccatcgcgagggggacCgtggcagcaagatggtctcc	8	5	15	13	4	1	1	0	0	1	1	3	4	1	2	4	4	1	2	4	4	1	0			TCGA-CN-4742-01A-02D-1512-08	TCGA-CN-4742-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fa89bda-b719-445a-85d2-76ce8c484b15	8e866e31-5135-4e6f-9f90-29d261fb14a9	g.chrX:153698457C>T	uc004flm.2	+	29	5106	c.4933C>T	c.(4933-4935)CGT>TGT	p.R1645C		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1645	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGAGGGGGACCGTGGCAGCAA	0.627													21	82					0	0	0	0	T	153698457	T	T	153698457	3	4	53	1	0	0	0	0	1	0	0	0	12176	652	23	1	5043	1	PLXNA3	23	153698457	Missense_Mutation	SNP	C	TCGA-CN-4742-01A-02D-1512-08	568054	153698457	1572103	100	10607											
NPHP4	261734	broad.mit.edu	37	chr1	6038470	6038470	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgacagtacctccagcaCgccctaggagacaacgggga	11	5	11	14	2	1	2	0	1	1	1	2	4	2	3	3	3	3	2	3	3	3	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:6038470C>T	uc001alq.1	-	3	405	c.139G>A	c.(139-141)GTG>ATG	p.V47M	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_RNA|NPHP4_uc001alt.1_Intron	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	47					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTCCAGCACGCCCTAGGAG	0.557													3	16					0	0	0	0	T	6038470	T	T	6038470	3	4	54	1	0	0	0	0	1	0	0	0	10635	536	19	1	4253	1	NPHP4	1	6038470	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08		6038470	243212151	1	10608											
EPHA2	1969	broad.mit.edu	37	chr1	16475542	16475542	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgttctgcatcaggtcccActgtggggggaagatacagg	9	9	15	8	0	2	1	1	0	1	1	3	3	3	2	1	5	2	2	1	5	2	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:16475542A>C	uc001aya.1	-	3	291	c.154T>G	c.(154-156)TGG>GGG	p.W52G	EPHA2_uc010oca.1_Missense_Mutation_p.W52G	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	52	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ATCAGGTCCCACTGTGGGGGG	0.557													11	58					0	0	0	0	C	16475542	C	C	16475542	3	2	54	1	0	0	0	0	1	0	0	0	5191	173	6	5	2836	5	EPHA2	1	16475542	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	10437072	16475542	232775079	2	10609											
ELTD1	64123	broad.mit.edu	37	chr1	79383352	79383352	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catgctggtcctataaaactCcaaataaagttgttttcggt	12	14	7	8	1	0	0	0	0	0	0	3	0	2	0	2	2	2	3	2	2	6	6			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:79383352C>A	uc001diq.3	-	12	1872	c.1716G>T	c.(1714-1716)TGG>TGT	p.W572C		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	572	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CTATAAAACTCCAAATAAAGT	0.279													10	46					3.86212e-05	4.0844e-05	1	0	A	79383352	A	A	79383352	3	1	54	1	0	0	0	0	1	0	0	0	5108	856	30	2	372	2	ELTD1	1	79383352	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	62907810	79383352	169867269	3	10610											
COL24A1	255631	broad.mit.edu	37	chr1	86591796	86591796	+	Frame_Shift_Del	DEL	C	-	-																															tcctgattctgttaaatggaCcccctgaggtaacggtgtag																										TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:86591796delC	uc001dlj.2	-	3	265	c.223delG	c.(223-225)GTCfs	p.V75fs	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Frame_Shift_Del_p.V75fs	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	75	TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GTTAAATGGACCCCCTGAGGT	0.428													---	---	---								-	86591796	-	-	86591796	7	5	54	1	0	1	0	1	0	0	0	0	3698	507	18	0	5153	0	COL24A1	1	86591796	Frame_Shift_Del	DEL	C	TCGA-CN-5355-01A-01D-1434-08	7208444	86591796	162658825	4	10611											
STXBP3	6814	broad.mit.edu	37	chr1	109295688	109295688	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttgtgtttgttttaagataAtgcttttagatgaatttacc	10	21	7	3	0	0	3	0	1	0	2	0	3	0	3	1	0	2	3	1	0	5	9			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:109295688A>T	uc001dvy.2	+	3	178	c.103A>T	c.(103-105)ATG>TTG	p.M35L	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	35	Mediates interaction with DOC2B (By similarity).				negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TTTTAAGATAATGCTTTTAGA	0.289													36	110					0	0	0	0	T	109295688	T	T	109295688	3	4	54	1	0	0	0	0	1	0	0	0	15420	101	4	5	113	5	STXBP3	1	109295688	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	22703892	109295688	139954933	5	10612											
NES	10763	broad.mit.edu	37	chr1	156647773	156647774	+	5'Flank	INS	-	ACAC	ACAC																															tgatattaggacacacggatINSacacacacacacacacacac																								rs138383128	by1000genomes	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:156647773_156647774insACAC	uc001fpq.2	-							NM_006617	NP_006608	P48681	NEST_HUMAN	nestin						brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					Gacacacggatacacacacaca	0.361											OREG0013882	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								ACAC	156647774	ACAC	ACAC	156647773	6	5	54	0	1	1	1	0	0	0	0	0	10391	1421	49	0		0	NES	1	156647773	5'Flank	INS	-	TCGA-CN-5355-01A-01D-1434-08	47352085	156647773	92602848	6	10613											
NME7	29922	broad.mit.edu	37	chr1	169200035	169200035	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccattgctacacaagggccaGaatacatttctgtcaccatg	12	10	7	12	0	2	1	1	0	1	1	2	1	2	1	3	1	3	1	3	1	4	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:169200035G>C	uc001gfu.2	-	10	1149	c.911C>G	c.(910-912)TCT>TGT	p.S304C	NME7_uc010plq.1_RNA|NME7_uc001gft.2_Missense_Mutation_p.S268C	NM_013330	NP_037462	Q9Y5B8	NDK7_HUMAN	nucleoside diphosphate kinase 7 isoform a	304					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)	1	all_hematologic(923;0.208)					ACAAGGGCCAGAATACATTTC	0.259													29	54					0	0	0	0	C	169200035	C	C	169200035	3	2	54	1	0	0	0	0	1	0	0	0	10550	942	33	2	231	2	NME7	1	169200035	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	12552262	169200035	80050586	7	10614											
KCNT2	343450	broad.mit.edu	37	chr1	196205130	196205130	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttacacaacatcattcagCtctattctggtatctggaga	12	13	6	10	0	5	1	2	0	3	1	5	2	5	1	0	2	3	2	0	2	4	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:196205130C>T	uc001gtd.1	-	27	3342	c.3282G>A	c.(3280-3282)GAG>GAA	p.E1094E	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.E1027E|KCNT2_uc001gtf.1_Silent_p.E1070E|KCNT2_uc001gtg.1_RNA	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1094	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CATCATTCAGCTCTATTCTGG	0.313													89	298					0	0	0	0	T	196205130	T	T	196205130	2	4	54	1	0	0	0	0	0	0	0	1	8131	796	28	4		4	KCNT2	1	196205130	Silent	SNP	C	TCGA-CN-5355-01A-01D-1434-08	27005095	196205130	53045491	8	10615											
MARK1	4139	broad.mit.edu	37	chr1	220825399	220825399	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgctgtcccctcagcacGaccccgccaccagaagtcca	8	6	7	20	2	2	1	1	0	1	1	4	2	4	1	7	0	2	2	7	0	1	0			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:220825399G>T	uc001hmn.3	+	15	2240	c.1643G>T	c.(1642-1644)CGA>CTA	p.R548L	MARK1_uc009xdw.2_Missense_Mutation_p.R548L|MARK1_uc010pun.1_Missense_Mutation_p.R548L|MARK1_uc001hmm.3_Missense_Mutation_p.R526L	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	548					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		CCCTCAGCACGACCCCGCCAC	0.512													20	116					0.00152264	0.00158743	1	0	T	220825399	T	T	220825399	3	4	54	1	0	0	0	0	1	0	0	0	9365	1058	37	3	1701	3	MARK1	1	220825399	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	24620269	220825399	28425222	9	10616											
C1orf124	83932	broad.mit.edu	37	chr1	231488769	231488769	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtttcatcttctaagataTccctaagaaattcttcaaaa	14	14	5	8	0	5	2	2	0	3	2	6	2	6	2	1	1	0	1	1	1	6	7			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:231488769T>C	uc001hur.2	+	5	1580	c.1132T>C	c.(1132-1134)TCC>CCC	p.S378P	C1orf124_uc001hus.2_3'UTR|C1orf124_uc001hut.2_3'UTR	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	378					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				TTCTAAGATATCCCTAAGAAA	0.418													25	77					0	0	0	0	C	231488769	C	C	231488769	3	2	54	1	0	0	0	0	1	0	0	0	2001	1435	50	5	1185	5	C1orf124	1	231488769	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08	10663370	231488769	17761852	10	10617											
RYR2	6262	broad.mit.edu	37	chr1	237870464	237870464	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgggccgagatgtgctgcAcagccctgaactcagagcac	11	5	12	13	2	1	3	1	1	0	2	1	4	1	3	2	1	6	3	2	1	2	0			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr1:237870464A>T	uc001hyl.1	+	68	9916	c.9796A>T	c.(9796-9798)ACA>TCA	p.T3266S	RYR2_uc010pxz.1_Missense_Mutation_p.T221S	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3266					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATGTGCTGCACAGCCCTGAA	0.478													11	60					0	0	0	0	T	237870464	T	T	237870464	3	4	54	1	0	0	0	0	1	0	0	0	13834	159	6	5	10066	5	RYR2	1	237870464	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	6381695	237870464	11380157	11	10618											
EML4	27436	broad.mit.edu	37	chr2	42557100	42557100	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaatctaatactcccacacCgcctccttctcagcccttaa	10	10	2	19	1	2	0	1	0	2	0	5	0	4	0	6	0	2	0	6	0	4	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:42557100C>G	uc002rsi.2	+	23	2961	c.2699C>G	c.(2698-2700)CCG>CGG	p.P900R	EML4_uc010fap.2_Missense_Mutation_p.P842R|EML4_uc002rsj.2_Missense_Mutation_p.P589R|EML4_uc010faq.2_Missense_Mutation_p.P245R|EML4_uc010ynv.1_Missense_Mutation_p.P164R	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	900					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						ACTCCCACACCGCCTCCTTCT	0.473			T	ALK	NSCLC								33	133					0	0	0	0	G	42557100	G	G	42557100	3	3	54	1	0	0	0	0	1	0	0	0	5123	652	23	3	2789	3	EML4	2	42557100	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08		42557100	200642273	12	10619											
NMS	129521	broad.mit.edu	37	chr2	101087010	101087010	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atctactgcttctgcatgctAcagattccctcctcaggtaa	9	13	6	13	0	3	1	1	0	2	1	5	1	5	1	2	1	5	4	2	1	3	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:101087010A>G	uc002tan.1	+	1	67	c.60A>G	c.(58-60)CTA>CTG	p.L20L		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	20					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						TCTGCATGCTACAGATTCCCT	0.537													34	153					0	0	0	0	G	101087010	G	G	101087010	2	3	54	1	0	0	0	0	0	0	0	1	10556	378	14	5		5	NMS	2	101087010	Silent	SNP	A	TCGA-CN-5355-01A-01D-1434-08	58529910	101087010	142112363	13	10620											
BCL2L11	10018	broad.mit.edu	37	chr2	111907687	111907687	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatcgcccaagagttgcggcGtattggagacgagtttaacg	10	9	14	8	5	0	2	0	0	0	2	1	5	0	2	1	2	2	3	1	2	3	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:111907687G>T	uc002tgv.1	+	3	749	c.461G>T	c.(460-462)CGT>CTT	p.R154L	BCL2L11_uc002tgu.1_Missense_Mutation_p.R94L|BCL2L11_uc002tgw.1_RNA|BCL2L11_uc002tgx.1_RNA|BCL2L11_uc010fkd.1_RNA|BCL2L11_uc002tgy.1_Intron|BCL2L11_uc002tgz.1_Missense_Mutation_p.R64L|BCL2L11_uc010fke.1_Intron|BCL2L11_uc002tha.1_Intron|BCL2L11_uc002thb.1_RNA|BCL2L11_uc002thc.1_RNA|BCL2L11_uc002thd.1_Intron	NM_138621	NP_619527	O43521	B2L11_HUMAN	BCL2-like 11 isoform 1	154	BH3.				activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|endomembrane system|mitochondrial outer membrane|plasma membrane	protein binding|protein binding				0						GAGTTGCGGCGTATTGGAGAC	0.448													11	45					2.10051e-16	2.61673e-16	1	0	T	111907687	T	T	111907687	3	4	54	1	0	0	0	0	1	0	0	0	1371	1145	40	3	596	3	BCL2L11	2	111907687	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	10820677	111907687	131291686	14	10621											
STEAP3	55240	broad.mit.edu	37	chr2	120003448	120003448	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcaagagcaccttcagcatCgtgagtccaatgctgagtac	12	8	10	11	1	1	3	1	2	0	1	3	3	2	3	2	0	5	5	2	0	3	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:120003448C>T	uc002tlp.2	+	3	533	c.376C>T	c.(376-378)CGT>TGT	p.R126C	STEAP3_uc002tlq.2_Missense_Mutation_p.R136C|STEAP3_uc002tlr.2_Missense_Mutation_p.R126C|STEAP3_uc010fle.2_Missense_Mutation_p.R126C	NM_018234	NP_060704	Q658P3	STEA3_HUMAN	dudulin 2 isoform b	126	Cytoplasmic (Potential).				apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			central_nervous_system(2)|skin(1)	3						CCTTCAGCATCGTGAGTCCAA	0.582													7	136					0	0	0	0	T	120003448	T	T	120003448	3	4	54	1	0	0	0	0	1	0	0	0	15345	884	31	1	412	1	STEAP3	2	120003448	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	8095761	120003448	123195925	15	10622											
RAB3GAP1	22930	broad.mit.edu	37	chr2	135809732	135809732	+	5'Flank	DEL	A	-	-																															tgagggcggactaaagacttAacagacctgggcgaagaagc																										TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:135809732delA	uc002tuj.2	+						RAB3GAP1_uc010fnf.2_5'Flank|RAB3GAP1_uc010fng.2_5'Flank	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein							centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		CTAAAGACTTAACAGACCTGG	0.358													---	---	---								-	135809732	-	-	135809732	6	5	54	0	1	1	0	1	0	0	0	0	13000	377	13	0		0	RAB3GAP1	2	135809732	5'Flank	DEL	A	TCGA-CN-5355-01A-01D-1434-08	15806284	135809732	107389641	16	10623											
LRP1B	53353	broad.mit.edu	37	chr2	141283518	141283518	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attacatcttatgaaccctgTggttttcactccaagcttat	10	16	5	10	0	2	1	1	1	1	0	3	1	3	1	2	1	3	2	2	1	5	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:141283518T>A	uc002tvj.1	-	49	8893	c.7921A>T	c.(7921-7923)ACA>TCA	p.T2641S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2641	Extracellular (Potential).|LDL-receptor class A 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGAACCCTGTGGTTTTCACT	0.383										TSP Lung(27;0.18)			22	64					0	0	0	0	A	141283518	A	A	141283518	3	1	54	1	0	0	0	0	1	0	0	0	9005	1696	59	5	6050	5	LRP1B	2	141283518	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08	5473786	141283518	101915855	17	10624											
NR4A2	4929	broad.mit.edu	37	chr2	157182714	157182715	+	Frame_Shift_Ins	INS	-	A	A																															aggcagaaatgtcgatgttcINSatattctgcaagttggagga																										TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:157182714_157182715insA	uc002tyz.3	-	7	1909_1910	c.1487_1488insT	c.(1486-1488)ATGfs	p.M496fs	NR4A2_uc002tyx.3_Frame_Shift_Ins_p.M433fs|NR4A2_uc010zcf.1_Frame_Shift_Ins_p.M496fs|NR4A2_uc010zcg.1_Frame_Shift_Ins_p.*78fs	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	496					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						TGTCGATGTTCATATTCTGCAA	0.515													---	---	---								A	157182715	A	A	157182714	7	5	54	1	0	1	1	0	0	0	0	0	10687	826	29	0	316	0	NR4A2	2	157182714	Frame_Shift_Ins	INS	-	TCGA-CN-5355-01A-01D-1434-08	15899196	157182714	86016659	18	10625											
MARCH7	64844	broad.mit.edu	37	chr2	160604745	160604745	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attgaattctgaaaattcttAcgtttctccaagaatcttga	13	16	5	7	1	4	4	0	3	4	1	5	4	4	4	1	0	1	1	1	0	6	6			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:160604745A>T	uc002uax.2	+	5	1066	c.944A>T	c.(943-945)TAC>TTC	p.Y315F	MARCH7_uc010foq.2_Missense_Mutation_p.Y315F|MARCH7_uc010zcn.1_Missense_Mutation_p.Y259F|MARCH7_uc010for.2_Missense_Mutation_p.Y277F|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	315	Ser-rich.						ligase activity|zinc ion binding				0						GAAAATTCTTACGTTTCTCCA	0.398													26	94					0	0	0	0	T	160604745	T	T	160604745	3	4	54	1	0	0	0	0	1	0	0	0	9359	391	14	5	958	5	MARCH7	2	160604745	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	3422031	160604745	82594628	19	10626											
COL4A3	1285	broad.mit.edu	37	chr2	228173694	228173694	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgatgtatgtaattttgcAtctcgaaatgattattcata	14	17	6	4	1	2	2	1	2	1	0	3	3	2	2	0	0	1	3	0	0	6	7			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr2:228173694A>T	uc002vom.1	+	49	4704	c.4542A>T	c.(4540-4542)GCA>GCT	p.A1514A	COL4A3_uc002von.1_Silent_p.A1514A|COL4A3_uc002voo.1_Intron|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron|COL4A3_uc010fxf.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1514	Required for the anti-angiogenic activity of tumstatin.|Collagen IV NC1.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GTAATTTTGCATCTCGAAATG	0.433													35	106					0	0	0	0	T	228173694	T	T	228173694	2	4	54	1	0	0	0	0	0	0	0	1	3706	204	8	5		5	COL4A3	2	228173694	Silent	SNP	A	TCGA-CN-5355-01A-01D-1434-08	67568949	228173694	15025679	20	10627											
RFT1	91869	broad.mit.edu	37	chr3	53156407	53156407	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaccttgagcttcacaaacaTatgtgcttgtgccaagaccc	11	10	8	12	0	1	2	1	1	0	1	1	3	1	2	3	0	4	2	3	0	3	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:53156407T>C	uc003dgj.2	-	4	493	c.439A>G	c.(439-441)ATG>GTG	p.M147V	RFT1_uc003dgk.2_Missense_Mutation_p.M108V	NM_052859	NP_443091	Q96AA3	RFT1_HUMAN	RFT1 homolog	147					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		TTCACAAACATATGTGCTTGT	0.443													44	93					0	0	0	0	C	53156407	C	C	53156407	3	2	54	1	0	0	0	0	1	0	0	0	13322	1406	49	5	1226	5	RFT1	3	53156407	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08		53156407	144866023	21	10628											
CACNA1D	776	broad.mit.edu	37	chr3	53699745	53699745	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gttcccctccttcacatagcCcttttggtattatttgtaat	7	18	5	11	0	1	0	1	0	0	0	3	0	3	0	4	1	1	3	4	1	4	9			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:53699745C>A	uc003dgv.3	+	6	988	c.825C>A	c.(823-825)GCC>GCA	p.A275A	CACNA1D_uc003dgu.3_Silent_p.A275A|CACNA1D_uc003dgy.3_Silent_p.A275A|CACNA1D_uc003dgw.3_5'Flank	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	275	Helical; Name=S5 of repeat I; (Potential).|I.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TTCACATAGCCCTTTTGGTAT	0.353													36	148					1.04594e-18	1.32546e-18	1	0	A	53699745	A	A	53699745	2	1	54	1	0	0	0	0	0	0	0	1	2553	610	22	4		4	CACNA1D	3	53699745	Silent	SNP	C	TCGA-CN-5355-01A-01D-1434-08	543338	53699745	144322685	22	10629											
NPHP3	27031	broad.mit.edu	37	chr3	132413714	132413714	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catcatttgccatggactccCggatagagtgcagaacaagt	12	9	10	10	1	1	2	1	0	0	2	2	4	2	4	2	2	3	1	2	2	3	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:132413714C>A	uc003epe.1	-	16	2344	c.2267G>T	c.(2266-2268)CGG>CTG	p.R756L	NPHP3_uc003epd.1_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	756					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CATGGACTCCCGGATAGAGTG	0.373													31	157					8.88839e-20	1.13617e-19	1	0	A	132413714	A	A	132413714	3	1	54	1	0	0	0	0	1	0	0	0	10634	652	23	3	1773	3	NPHP3	3	132413714	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	78713969	132413714	65608716	23	10630											
PLSCR2	57047	broad.mit.edu	37	chr3	146171942	146171942	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggtacaccaggaggagcttgGatttctatctacaaaagtaa	14	10	10	7	0	2	0	0	0	2	0	2	3	2	3	1	4	3	3	1	4	6	6			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:146171942G>A	uc003evv.1	-	6	663	c.330C>T	c.(328-330)ATC>ATT	p.I110I	PLSCR2_uc003evw.1_Silent_p.I179I	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	110	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						GAGGAGCTTGGATTTCTATCT	0.264													14	56					0	0	0	0	A	146171942	A	A	146171942	2	1	54	1	0	0	0	0	0	0	0	1	12165	1164	41	2		2	PLSCR2	3	146171942	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08	13758228	146171942	51850488	24	10631											
IL12A	3592	broad.mit.edu	37	chr3	159710911	159710911	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttaccattggaattaaccaAggtataaaggattttcctcc	13	14	6	8	0	0	0	0	0	0	0	2	2	2	2	4	3	2	1	4	3	7	8			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:159710911A>T	uc003fcx.2	+	3	592	c.377A>T	c.(376-378)AAG>ATG	p.K126M	uc003fcw.1_Intron	NM_000882	NP_000873	P29459	IL12A_HUMAN	interleukin 12A precursor	92					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GAATTAACCAAGGTATAAAGG	0.383													24	99					0	0	0	0	T	159710911	T	T	159710911	3	4	54	1	0	0	0	0	1	0	0	0	7663	86	3	5	387	5	IL12A	3	159710911	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	13538969	159710911	38311519	25	10632											
SERPINI1	5274	broad.mit.edu	37	chr3	167525118	167525118	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcaaagatgcaaatttgaCaggcctctctggtaagaaat	15	10	8	8	0	2	3	1	1	1	2	3	3	2	3	1	2	1	2	1	2	4	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:167525118C>A	uc003ffa.3	+	6	1166	c.968C>A	c.(967-969)ACA>AAA	p.T323K	SERPINI1_uc003ffb.3_Missense_Mutation_p.T323K	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	323					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						GCAAATTTGACAGGCCTCTCT	0.303													26	129					1.85244e-09	2.14416e-09	1	0	A	167525118	A	A	167525118	3	1	54	1	0	0	0	0	1	0	0	0	14183	478	17	4	986	4	SERPINI1	3	167525118	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	7814207	167525118	30497312	26	10633											
SPATA16	83893	broad.mit.edu	37	chr3	172835423	172835423	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgttaggtgggtgcgctaaGgtggacattttcttgcttgt	6	16	14	5	1	1	0	0	0	1	0	1	1	1	1	0	4	2	3	0	4	2	6			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:172835423G>C	uc003fin.3	-	2	257	c.99C>G	c.(97-99)ACC>ACG	p.T33T		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	33					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GGTGCGCTAAGGTGGACATTT	0.403													207	423					0	0	0	0	C	172835423	C	C	172835423	2	2	54	1	0	0	0	0	0	0	0	1	15067	987	35	4		4	SPATA16	3	172835423	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08	5310305	172835423	25187007	27	10634											
CPN2	1370	broad.mit.edu	37	chr3	194062541	194062541	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acagtctccagctggttatgGgtcagagacaggccaaccag	11	7	12	11	0	2	1	1	0	1	1	3	2	2	1	3	3	2	2	3	3	2	1	rs140809499	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr3:194062541G>A	uc003fts.2	-	2	981	c.891C>T	c.(889-891)ACC>ACT	p.T297T		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	297	LRR 9.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GCTGGTTATGGGTCAGAGACA	0.587													25	64					0	0	0	0	A	194062541	A	A	194062541	2	1	54	1	0	0	0	0	0	0	0	1	3825	1219	43	4		4	CPN2	3	194062541	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08	21227118	194062541	3959889	28	10635											
WHSC1	7468	broad.mit.edu	37	chr4	1957915	1957915	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcggaagagtcttcaaaaacGgtacggagatattcagatag	15	9	11	6	3	3	3	2	0	1	3	4	5	3	4	0	3	2	1	0	3	6	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:1957915G>T	uc003gdz.3	+	15	3057	c.2881G>T	c.(2881-2883)GCA>TCA	p.A961S	WHSC1_uc003geb.3_Missense_Mutation_p.A961S|WHSC1_uc003gec.3_Missense_Mutation_p.A961S|WHSC1_uc003ged.3_Missense_Mutation_p.A961S|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.A180S|WHSC1_uc011bvh.1_Missense_Mutation_p.A22S|WHSC1_uc010icf.2_Missense_Mutation_p.A309S	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	961					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CTTCAAAAACGGTACGGAGAT	0.463			T	IGH@	MM								15	138					2.31682e-05	2.48593e-05	1	0	T	1957915	T	T	1957915	3	4	54	1	0	0	0	0	1	0	0	0	17430	1130	39	3	3011	3	WHSC1	4	1957915	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08		1957915	189196361	29	10636											
YIPF7	285525	broad.mit.edu	37	chr4	44626759	44626759	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaatcacaaggcagccaatgGcactcatgccatacacataa	16	6	7	12	0	2	0	2	0	0	0	2	1	2	0	2	2	3	2	2	2	5	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:44626759G>T	uc010ifx.1	-	5	556	c.539C>A	c.(538-540)GCC>GAC	p.A180D		NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	180	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0						GCAGCCAATGGCACTCATGCC	0.507													3	15					1.23904e-05	1.33926e-05	1	0	T	44626759	T	T	44626759	3	4	54	1	0	0	0	0	1	0	0	0	17551	1203	42	4	311	4	YIPF7	4	44626759	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	42668844	44626759	146527517	30	10637											
CXCL10	3627	broad.mit.edu	37	chr4	76943875	76943875	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgtggacaaaattggcttgCaggaataatttcaagttttt	13	14	9	5	1	1	0	1	0	0	0	1	2	1	2	0	3	1	3	0	3	5	6			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:76943875C>G	uc003hjl.3	-	2	227	c.157G>C	c.(157-159)GCA>CCA	p.A53P	ART3_uc003hji.2_Intron|ART3_uc003hjj.2_Intron|ART3_uc003hjk.2_Intron	NM_001565	NP_001556	P02778	CXL10_HUMAN	small inducible cytokine B10 precursor	53					blood circulation|cell surface receptor linked signaling pathway|cell-cell signaling|chemotaxis|inflammatory response|muscle organ development|positive regulation of cell proliferation	extracellular space	cAMP-dependent protein kinase regulator activity|chemokine activity				0			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AATTGGCTTGCAGGAATAATT	0.363													17	103					0	0	0	0	G	76943875	G	G	76943875	3	3	54	1	0	0	0	0	1	0	0	0	4095	710	25	4	151	4	CXCL10	4	76943875	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	32317116	76943875	114210401	31	10638											
SEC31A	22872	broad.mit.edu	37	chr4	83770026	83770026	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaactggtccaggcctgccCttggggagctgctgtttctc	4	11	13	13	0	1	0	0	0	1	0	3	1	2	1	3	4	4	4	3	4	1	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:83770026C>A	uc003hnf.2	-	20	2597	c.2433G>T	c.(2431-2433)AAG>AAT	p.K811N	SEC31A_uc003hne.2_Missense_Mutation_p.K544N|SEC31A_uc011ccl.1_Missense_Mutation_p.K772N|SEC31A_uc003hnl.2_Missense_Mutation_p.K772N|SEC31A_uc003hng.2_Missense_Mutation_p.K811N|SEC31A_uc003hnh.2_Missense_Mutation_p.K811N|SEC31A_uc003hni.2_Missense_Mutation_p.K811N|SEC31A_uc003hnj.2_Missense_Mutation_p.K772N|SEC31A_uc011ccm.1_Missense_Mutation_p.K806N|SEC31A_uc011ccn.1_Missense_Mutation_p.K811N|SEC31A_uc003hnk.2_Missense_Mutation_p.K772N|SEC31A_uc003hnm.2_Missense_Mutation_p.K811N|SEC31A_uc003hnn.1_Missense_Mutation_p.K811N	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	811	Interaction with PDCD6.|Pro-rich.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				CAGGCCTGCCCTTGGGGAGCT	0.488													28	118					1.88708e-17	2.37095e-17	1	0	A	83770026	A	A	83770026	3	1	54	1	0	0	0	0	1	0	0	0	14063	680	24	4	1261	4	SEC31A	4	83770026	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	6826151	83770026	107384250	32	10639											
ALPK1	80216	broad.mit.edu	37	chr4	113359713	113359713	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgtggagcgacagatgaccGcacagcactatgtgacagaa	14	6	12	9	2	0	4	0	2	0	2	0	6	0	5	1	1	2	2	1	1	2	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:113359713G>C	uc003iap.3	+	13	3541	c.3262G>C	c.(3262-3264)GCA>CCA	p.A1088P	ALPK1_uc003ian.3_Missense_Mutation_p.A1088P|ALPK1_uc011cfx.1_Missense_Mutation_p.A1010P|ALPK1_uc003iao.3_RNA|ALPK1_uc010imo.2_Missense_Mutation_p.A916P	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1088	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		ACAGATGACCGCACAGCACTA	0.428													39	151					0	0	0	0	C	113359713	C	C	113359713	3	2	54	1	0	0	0	0	1	0	0	0	544	1087	38	3	3304	3	ALPK1	4	113359713	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	29589687	113359713	77794563	33	10640											
PCDH10	57575	broad.mit.edu	37	chr4	134071805	134071805	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagctacttctccctggaCgtgcagacccagggggatgg	9	7	13	12	1	1	1	0	0	1	1	2	3	1	3	2	4	4	2	2	4	2	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:134071805C>T	uc003iha.2	+	1	1336	c.510C>T	c.(508-510)GAC>GAT	p.D170D	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.D170D	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	170	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TCTCCCTGGACGTGCAGACCC	0.637													20	101					0	0	0	0	T	134071805	T	T	134071805	2	4	54	1	0	0	0	0	0	0	0	1	11561	535	19	1		1	PCDH10	4	134071805	Silent	SNP	C	TCGA-CN-5355-01A-01D-1434-08	20712092	134071805	57082471	34	10641											
GYPE	2996	broad.mit.edu	37	chr4	144826671	144826671	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccatacatcctgagatcaCgagctggctcctgaagttag	10	11	9	11	1	1	2	1	2	0	1	4	4	4	2	3	1	2	3	3	1	3	3			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr4:144826671C>T	uc003ijj.2	-	1	46	c.-10G>A	c.(-12--8)TCGTG>TCATG		GYPE_uc010ion.2_RNA|GYPE_uc003ijk.3_Translation_Start_Site	NM_198682	NP_941391	P15421	GLPE_HUMAN	glycophorin E precursor							integral to plasma membrane					0	all_hematologic(180;0.158)					CCTGAGATCACGAGCTGGCTC	0.398													4	81					0	0	0	0	T	144826671	T	T	144826671	1	4	54	1	0	0	0	0	0	0	0	0	6950	551	19	1		1	GYPE	4	144826671	Translation_Start_Site	SNP	C	TCGA-CN-5355-01A-01D-1434-08	10754866	144826671	46327605	35	10642											
CDH9	1007	broad.mit.edu	37	chr5	26988326	26988326	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accgtcatcttttgtcagacCcgctatctttttgcttgata	7	17	6	11	2	4	2	2	1	2	1	4	2	4	2	2	0	1	2	2	0	2	7			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:26988326C>G	uc003jgs.1	-	2	284	c.115G>C	c.(115-117)GGT>CGT	p.G39R	CDH9_uc010iug.2_Missense_Mutation_p.G39R	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	39					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTTGTCAGACCCGCTATCTTT	0.393													32	73					0	0	0	0	G	26988326	G	G	26988326	3	3	54	1	0	0	0	0	1	0	0	0	3132	623	22	4	2298	4	CDH9	5	26988326	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08		26988326	153926934	36	10643											
ISL1	3670	broad.mit.edu	37	chr5	50687247	50687247	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgacttcgccttgcagagtgAcatagatcagcctgcttttc	8	12	9	12	2	1	3	1	1	0	2	3	4	1	3	2	0	3	2	2	0	1	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:50687247A>T	uc003jor.2	+	5	1453	c.905A>T	c.(904-906)GAC>GTC	p.D302V		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	302	Gln-rich.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				TTGCAGAGTGACATAGATCAG	0.498													25	77					0	0	0	0	T	50687247	T	T	50687247	3	4	54	1	0	0	0	0	1	0	0	0	7895	275	10	5	923	5	ISL1	5	50687247	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	23698921	50687247	130228013	37	10644											
ESM1	11082	broad.mit.edu	37	chr5	54275232	54275232	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcacaacttcttctctcacAatattgccatctccagatgc	10	14	3	14	0	5	1	2	0	3	1	7	1	5	1	2	0	3	0	2	0	3	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:54275232A>G	uc003jpk.2	-	3	552	c.483T>C	c.(481-483)ATT>ATC	p.I161I	ESM1_uc010ivt.2_Silent_p.I111I	NM_007036	NP_008967	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1 isoform a	161					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			CTTCTCTCACAATATTGCCAT	0.433													19	134					0	0	0	0	G	54275232	G	G	54275232	2	3	54	1	0	0	0	0	0	0	0	1	5276	126	5	5		5	ESM1	5	54275232	Silent	SNP	A	TCGA-CN-5355-01A-01D-1434-08	3587985	54275232	126640028	38	10645											
PCDHB14	56122	broad.mit.edu	37	chr5	140604627	140604627	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggccacctgtttgccctcaGgtcgctggactacgaggccc	5	9	12	15	2	1	0	1	0	0	0	2	2	1	1	4	4	2	2	4	4	1	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:140604627G>C	uc003ljb.2	+	1	1550	c.1550G>C	c.(1549-1551)AGG>ACG	p.R517T	PCDHB14_uc011dal.1_Missense_Mutation_p.R364T	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	517	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTGCCCTCAGGTCGCTGGAC	0.682													20	153					0	0	0	0	C	140604627	C	C	140604627	3	2	54	1	0	0	0	0	1	0	0	0	11593	1000	35	4	1552	4	PCDHB14	5	140604627	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	86329395	140604627	40310633	39	10646											
C5orf54	63920	broad.mit.edu	37	chr5	159821393	159821393	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctaggtgaattttaaactCtttattttcaaagccatcaa	13	16	5	7	0	3	1	2	1	1	0	3	1	3	1	1	1	3	1	1	1	7	7			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:159821393C>A	uc003lye.1	-	2	1569	c.1105G>T	c.(1105-1107)GAG>TAG	p.E369*	C5orf54_uc003lyf.1_Nonsense_Mutation_p.E369*	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	369										pancreas(1)	1						attttaaactctttattttca	0													20	80					3.51602e-12	4.13484e-12	1	0	A	159821393	A	A	159821393	4	1	54	1	0	0	0	0	0	1	0	0	2320	922	32	2	683	2	C5orf54	5	159821393	Nonsense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	19216766	159821393	21093867	40	10647											
ATP10B	23120	broad.mit.edu	37	chr5	159992486	159992486	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtcagtgaactctgggatcGgcgatggctgctcctctttg	5	12	14	10	2	3	1	1	1	2	0	5	3	4	2	1	4	2	2	1	4	1	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:159992486G>T	uc003lym.1	-	26	5207	c.4360C>A	c.(4360-4362)CGA>AGA	p.R1454R	ATP10B_uc010jit.1_Silent_p.R704R	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1454	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCTGGGATCGGCGATGGCTG	0.527													37	100					1.42033e-22	1.83148e-22	1	0	T	159992486	T	T	159992486	2	4	54	1	0	0	0	0	0	0	0	1	1119	1124	39	3		3	ATP10B	5	159992486	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08	171093	159992486	20922774	41	10648											
GRM6	2916	broad.mit.edu	37	chr5	178413301	178413301	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccaggaagagcctgcgggCggcacagaccgcggccccag	8	1	16	16	4	0	2	0	0	0	2	0	3	0	3	5	4	2	1	5	4	1	0	rs150850494		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr5:178413301C>T	uc003mjr.2	-	8	2133	c.1954G>A	c.(1954-1956)GCC>ACC	p.A652T	GRM6_uc003mjq.2_5'Flank|GRM6_uc010jla.1_Missense_Mutation_p.A235T|GRM6_uc003mjs.1_Missense_Mutation_p.A272T	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	652	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AGCCTGCGGGCGGCACAGACC	0.642													4	21					0	0	0	0	T	178413301	T	T	178413301	3	4	54	1	0	0	0	0	1	0	0	0	6840	768	27	1	691	1	GRM6	5	178413301	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	18420815	178413301	2501959	42	10649											
MDC1	9656	broad.mit.edu	37	chr6	30680344	30680344	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttccactgggagctcttcctCctccacgtctgtgtcactgt	4	14	8	15	1	3	0	1	0	2	0	7	1	7	1	4	1	1	1	4	1	0	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:30680344C>T	uc003nrg.3	-	5	1815	c.1375G>A	c.(1375-1377)GAG>AAG	p.E459K	MDC1_uc003nrf.3_Missense_Mutation_p.E113K|MDC1_uc011dmp.1_Missense_Mutation_p.E331K|MDC1_uc003nrh.1_Missense_Mutation_p.E331K|MDC1_uc003nri.2_Missense_Mutation_p.E459K	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	459	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						AGCTCTTCCTCCTCCACGTCT	0.493								Other_conserved_DNA_damage_response_genes					35	133					0	0	0	0	T	30680344	T	T	30680344	3	4	54	1	0	0	0	0	1	0	0	0	9456	864	30	2	4938	2	MDC1	6	30680344	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08		30680344	140434723	43	10650											
BTBD9	114781	broad.mit.edu	37	chr6	38256211	38256211	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatcacactggcacaatcagCaattgttgcaacattctcca	14	10	5	12	0	3	0	2	0	1	0	4	0	3	0	1	1	3	4	1	1	4	3			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:38256211C>A	uc003ooa.3	-	9	1867	c.1291G>T	c.(1291-1293)GCT>TCT	p.A431S	BTBD9_uc003ony.3_Missense_Mutation_p.A363S|BTBD9_uc010jwv.2_Missense_Mutation_p.A392S|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.A431S	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	431					cell adhesion						0						GCACAATCAGCAATTGTTGCA	0.428													18	75					5.35267e-07	5.96092e-07	1	0	A	38256211	A	A	38256211	3	1	54	1	0	0	0	0	1	0	0	0	1553	710	25	4	563	4	BTBD9	6	38256211	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	7575867	38256211	132858856	44	10651											
TTK	7272	broad.mit.edu	37	chr6	80720550	80720550	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtaatgtcaaaaaaagtaaAcaacttcttcaaaaagctgt	19	10	6	6	0	3	0	2	0	1	0	3	0	3	0	0	1	3	3	0	1	9	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:80720550A>G	uc003pjc.2	+	5	563	c.489A>G	c.(487-489)AAA>AAG	p.K163K	TTK_uc003pjb.3_Silent_p.K163K	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	163					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		AAAAAAGTAAACAACTTCTTC	0.398													21	51					0	0	0	0	G	80720550	G	G	80720550	2	3	54	1	0	0	0	0	0	0	0	1	16788	40	2	5		5	TTK	6	80720550	Silent	SNP	A	TCGA-CN-5355-01A-01D-1434-08	42464339	80720550	90394517	45	10652											
MICAL1	64780	broad.mit.edu	37	chr6	109773738	109773738	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agggacgaatttacctcctgCagccgagataaggacgtcaa	13	7	11	10	3	1	1	1	0	0	1	2	5	2	3	3	2	3	1	3	2	4	3			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:109773738C>T	uc003ptj.2	-	4	906	c.652G>A	c.(652-654)GCA>ACA	p.A218T	MICAL1_uc003ptk.2_Missense_Mutation_p.A218T|MICAL1_uc010kdr.2_Missense_Mutation_p.A218T|MICAL1_uc011eaq.1_Missense_Mutation_p.A237T	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	218					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		TTACCTCCTGCAGCCGAGATA	0.557													15	43					0	0	0	0	T	109773738	T	T	109773738	3	4	54	1	0	0	0	0	1	0	0	0	9622	710	25	4	2635	4	MICAL1	6	109773738	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	29053188	109773738	61341329	46	10653											
GRM1	2911	broad.mit.edu	37	chr6	146755141	146755141	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	accaaacagccgtcatcaagCccctcactaaaagttaccaa	16	6	4	15	1	3	0	3	0	0	0	3	0	3	0	5	0	4	1	5	0	6	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr6:146755141C>A	uc010khw.1	+	9	3264	c.2794C>A	c.(2794-2796)CCC>ACC	p.P932T	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	932	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CGTCATCAAGCCCCTCACTAA	0.557													33	136					7.11191e-15	8.64009e-15	1	0	A	146755141	A	A	146755141	3	1	54	1	0	0	0	0	1	0	0	0	6835	739	26	4	2889	4	GRM1	6	146755141	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	36981403	146755141	24359926	47	10654											
ZNF12	7559	broad.mit.edu	37	chr7	6731084	6731084	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaataactttccacattCattacattcgtaaggtttct	12	15	6	8	1	2	1	1	0	1	1	4	2	3	1	1	2	2	2	1	2	4	7			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:6731084C>A	uc003sqt.1	-	5	2043	c.1489G>T	c.(1489-1491)GAA>TAA	p.E497*	ZNF12_uc011jxa.1_Nonsense_Mutation_p.E335*|ZNF12_uc003sqs.1_Nonsense_Mutation_p.E459*	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	497	C2H2-type 9.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TTTCCACATTCATTACATTCG	0.398													48	180					2.65591e-33	3.58182e-33	1	0	A	6731084	A	A	6731084	4	1	54	1	0	0	0	0	0	1	0	0	17785	835	29	2	608	2	ZNF12	7	6731084	Nonsense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08		6731084	152407579	48	10655											
ABCA13	154664	broad.mit.edu	37	chr7	48413965	48413965	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccttctttcgacaaccgccTttggacaaggggtatttttt	7	15	9	10	2	1	0	0	0	1	0	2	2	1	1	3	3	1	1	3	3	3	7			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:48413965T>G	uc003toq.2	+	34	11180	c.11155T>G	c.(11155-11157)TTT>GTT	p.F3719V	ABCA13_uc010kys.1_Missense_Mutation_p.F793V|ABCA13_uc003tos.1_Missense_Mutation_p.F545V|ABCA13_uc010kyt.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3719	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GACAACCGCCTTTGGACAAGG	0.413													5	19					0	0	0	0	G	48413965	G	G	48413965	3	3	54	1	0	0	0	0	1	0	0	0	31	1609	56	5	11118	5	ABCA13	7	48413965	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08	41682881	48413965	110724698	49	10656											
EPHB4	2050	broad.mit.edu	37	chr7	100414856	100414856	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttcctggccgaagggccCgtagccggcctcagagcgcg	6	6	15	14	5	1	1	1	0	0	1	2	2	2	1	5	3	2	2	5	3	2	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:100414856C>T	uc003uwn.1	-	8	2037	c.1546G>A	c.(1546-1548)GGG>AGG	p.G516R	EPHB4_uc003uwm.1_Missense_Mutation_p.G423R|EPHB4_uc010lhj.1_Missense_Mutation_p.G516R|EPHB4_uc011kkf.1_Intron|EPHB4_uc011kkg.1_3'UTR	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	516	Extracellular (Potential).|Fibronectin type-III 2.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCGAAGGGCCCGTAGCCGGCC	0.657													7	31					0	0	0	0	T	100414856	T	T	100414856	3	4	54	1	0	0	0	0	1	0	0	0	5201	652	23	1	1457	1	EPHB4	7	100414856	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	52000891	100414856	58723807	50	10657											
IMMP2L	83943	broad.mit.edu	37	chr7	110303688	110303688	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctctgtactggtaagcgCtctggaggaagaacagattc	10	11	11	9	1	3	2	0	0	3	2	5	4	3	4	0	3	3	3	0	3	4	3			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:110303688C>A	uc003vfq.1	-	6	941	c.498G>T	c.(496-498)GAG>GAT	p.E166D	IMMP2L_uc010ljr.1_Missense_Mutation_p.E166D	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	166					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		CTGGTAAGCGCTCTGGAGGAA	0.493													33	110					2.08457e-15	2.5536e-15	1	0	A	110303688	A	A	110303688	3	1	54	1	0	0	0	0	1	0	0	0	7756	796	28	4	33	4	IMMP2L	7	110303688	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	9888832	110303688	48834975	51	10658											
AHCYL2	23382	broad.mit.edu	37	chr7	129053482	129053482	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acttggaccgtatgaagaatAgctgcatcgtttgtaacatg	12	12	10	7	2	0	2	0	1	0	1	1	3	0	3	1	1	3	5	1	1	5	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr7:129053482A>G	uc011kov.1	+	12	1468	c.1414A>G	c.(1414-1416)AGC>GGC	p.S472G	AHCYL2_uc003vot.2_Missense_Mutation_p.S471G|AHCYL2_uc003vov.2_Missense_Mutation_p.S369G|AHCYL2_uc011kow.1_Missense_Mutation_p.S370G|AHCYL2_uc011kox.1_Missense_Mutation_p.S369G	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	472					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						TATGAAGAATAGCTGCATCGT	0.403													23	104					0	0	0	0	G	129053482	G	G	129053482	3	3	54	1	0	0	0	0	1	0	0	0	411	420	15	5	1582	5	AHCYL2	7	129053482	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	18749794	129053482	30085181	52	10659											
PREX2	80243	broad.mit.edu	37	chr8	69028102	69028102	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacagcaaacgggtatgtttTaatgtagcaggagatgaaca	16	9	11	5	1	0	2	0	1	0	1	0	3	0	2	0	2	5	5	0	2	6	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:69028102T>C	uc003xxv.1	+	26	3288	c.3261T>C	c.(3259-3261)TTT>TTC	p.F1087F		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1087					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GGGTATGTTTTAATGTAGCAG	0.383													33	163					0	0	0	0	C	69028102	C	C	69028102	2	2	54	1	0	0	0	0	0	0	0	1	12539	1751	61	5		5	PREX2	8	69028102	Silent	SNP	T	TCGA-CN-5355-01A-01D-1434-08		69028102	77335920	53	10660											
RUNX1T1	862	broad.mit.edu	37	chr8	93017415	93017415	+	Frame_Shift_Del	DEL	G	-	-																															gaggagtcaacaggtgaggtGgtgctggcatccagaagcag																										TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:93017415delG	uc003yfd.2	-	5	753	c.669delC	c.(667-669)ACCfs	p.T223fs	RUNX1T1_uc003yfc.1_Frame_Shift_Del_p.T196fs|RUNX1T1_uc003yfe.1_Frame_Shift_Del_p.T186fs|RUNX1T1_uc010mao.2_Frame_Shift_Del_p.T196fs|RUNX1T1_uc011lgi.1_Frame_Shift_Del_p.T234fs|RUNX1T1_uc003yfb.1_Frame_Shift_Del_p.T186fs|RUNX1T1_uc003yff.1_Frame_Shift_Del_p.T186fs	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	223					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAGGTGAGGTGGTGCTGGCAT	0.592													---	---	---								-	93017415	-	-	93017415	7	5	54	1	0	1	0	1	0	0	0	0	13812	1335	47	0	1173	0	RUNX1T1	8	93017415	Frame_Shift_Del	DEL	G	TCGA-CN-5355-01A-01D-1434-08	23989313	93017415	53346607	54	10661											
SDC2	6383	broad.mit.edu	37	chr8	97614673	97614673	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgacaacatctcgaccacttCcaaagatactgttgactagt	13	11	6	11	1	1	3	0	2	1	1	3	4	2	3	2	0	2	1	2	0	4	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:97614673C>T	uc003yhv.1	+	3	841	c.223C>T	c.(223-225)CCA>TCA	p.P75S	SDC2_uc011lgu.1_Missense_Mutation_p.P46S	NM_002998	NP_002989	P34741	SDC2_HUMAN	syndecan 2 precursor	75	Extracellular (Potential).					integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			ovary(2)	2	Breast(36;3.41e-05)				Sargramostim(DB00020)	TCGACCACTTCCAAAGATACT	0.448													36	148					0	0	0	0	T	97614673	T	T	97614673	3	4	54	1	0	0	0	0	1	0	0	0	14017	855	30	2	233	2	SDC2	8	97614673	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	4597258	97614673	48749349	55	10662											
CSMD3	114788	broad.mit.edu	37	chr8	114111056	114111056	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccatttgaaaatcagtaaaTatgagtgaaattgtgtcccc	14	13	7	7	0	1	3	1	3	0	0	3	3	3	3	3	0	0	1	3	0	6	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:114111056T>C	uc003ynu.2	-	5	1005	c.846A>G	c.(844-846)ATA>ATG	p.I282M	CSMD3_uc003ynt.2_Missense_Mutation_p.I242M|CSMD3_uc011lhx.1_Missense_Mutation_p.I282M|CSMD3_uc010mcx.1_Missense_Mutation_p.I282M	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	282	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATCAGTAAATATGAGTGAAA	0.383										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	118					0	0	0	0	C	114111056	C	C	114111056	3	2	54	1	0	0	0	0	1	0	0	0	3963	1396	49	5	10545	5	CSMD3	8	114111056	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08	16496383	114111056	32252966	56	10663											
ADCY8	114	broad.mit.edu	37	chr8	131793033	131793033	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taacccccgtgctgtccattCggcttgccaggttcacagtt	6	12	9	14	2	1	0	1	0	0	0	3	0	2	0	4	2	3	4	4	2	1	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:131793033C>T	uc003ytd.3	-	18	3615	c.3359G>A	c.(3358-3360)CGA>CAA	p.R1120Q	ADCY8_uc010mds.2_Missense_Mutation_p.R989Q	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1120	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GCTGTCCATTCGGCTTGCCAG	0.567										HNSCC(32;0.087)			64	304					0	0	0	0	T	131793033	T	T	131793033	3	4	54	1	0	0	0	0	1	0	0	0	300	884	31	1	400	1	ADCY8	8	131793033	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	17681977	131793033	14570989	57	10664											
TMEM71	137835	broad.mit.edu	37	chr8	133764056	133764056	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taagttctccttatacataaCgctggtctgggatgggttca	9	14	10	8	1	3	0	1	0	2	0	4	1	3	1	1	3	2	3	1	3	4	6	rs111461300	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:133764056C>A	uc003ytp.2	-	4	518	c.289G>T	c.(289-291)GTT>TTT	p.V97F	TMEM71_uc003ytn.2_Missense_Mutation_p.V97F|TMEM71_uc003yto.2_Missense_Mutation_p.V97F	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	97						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TTATACATAACGCTGGTCTGG	0.388													54	233					3.21867e-24	4.22451e-24	1	0	A	133764056	A	A	133764056	3	1	54	1	0	0	0	0	1	0	0	0	16266	536	19	3	626	3	TMEM71	8	133764056	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	1971023	133764056	12599966	58	10665											
FAM135B	51059	broad.mit.edu	37	chr8	139164635	139164635	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgggcctctgaccaggcgaCggagcttggctcactctcaa	7	8	12	14	3	3	1	2	1	2	0	5	3	3	2	2	4	1	2	2	4	1	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr8:139164635C>A	uc003yuy.2	-	13	2254	c.2083G>T	c.(2083-2085)GTC>TTC	p.V695F	FAM135B_uc003yux.2_Missense_Mutation_p.V596F|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.V257F|FAM135B_uc003yvb.2_Missense_Mutation_p.V257F	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	695										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GACCAGGCGACGGAGCTTGGC	0.552										HNSCC(54;0.14)			30	97					1.32181e-22	1.71952e-22	1	0	A	139164635	A	A	139164635	3	1	54	1	0	0	0	0	1	0	0	0	5477	536	19	3	2169	3	FAM135B	8	139164635	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	5400579	139164635	7199387	59	10666											
TPD52L3	89882	broad.mit.edu	37	chr9	6330998	6330998	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgatcttcaataaatacacGttaaatcaaggaaggaatta	18	12	6	5	1	3	1	2	1	1	0	3	3	3	3	0	2	1	1	0	2	10	6			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:6330998G>A	uc003zjx.1	+	2	611	c.390G>A	c.(388-390)ACG>ACA	p.T130T		NM_001001874	NP_001001874	Q96J77	TPD55_HUMAN	protein kinase NYD-SP25 isoform 2	Error:Variant_position_missing_in_Q96J77_after_alignment							protein binding				0		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		ATAAATACACGTTAAATCAAG	0.313													23	118					0	0	0	0	A	6330998	A	A	6330998	2	1	54	1	0	0	0	0	0	0	0	1	16467	1132	40	1		1	TPD52L3	9	6330998	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08		6330998	134882433	60	10667											
CNTLN	54875	broad.mit.edu	37	chr9	17236462	17236462	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaacagactagttataaaaaAtctggaggaggaaaacaaga	22	6	9	4	0	1	2	0	0	1	2	1	5	1	5	0	3	2	1	0	3	9	3			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:17236462A>T	uc003zmz.2	+	5	751	c.725A>T	c.(724-726)AAT>ATT	p.N242I	CNTLN_uc003zmx.3_Missense_Mutation_p.N242I|CNTLN_uc003zmy.2_Missense_Mutation_p.N242I|CNTLN_uc010mio.2_5'UTR	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	242						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		GTTATAAAAAATCTGGAGGAG	0.378													30	142					0	0	0	0	T	17236462	T	T	17236462	3	4	54	1	0	0	0	0	1	0	0	0	3654	101	4	5	743	5	CNTLN	9	17236462	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	10905464	17236462	123976969	61	10668											
C9orf135	138255	broad.mit.edu	37	chr9	72472845	72472845	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcaccggattgcctgccaCaggttttggagctgtctttc	5	13	12	11	1	2	0	1	0	1	0	3	2	2	2	3	4	3	2	3	4	0	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:72472845C>T	uc004ahl.2	+	4	466	c.401C>T	c.(400-402)ACA>ATA	p.T134I	C9orf135_uc011lrw.1_Missense_Mutation_p.T26I|C9orf135_uc010moq.2_Missense_Mutation_p.T26I|C9orf135_uc011lrx.1_RNA|C9orf135_uc010mop.2_Missense_Mutation_p.T134I	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255	134	Helical; (Potential).					integral to membrane				ovary(1)	1						TTGCCTGCCACAGGTTTTGGA	0.368													71	129					0	0	0	0	T	72472845	T	T	72472845	3	4	54	1	0	0	0	0	1	0	0	0	2470	478	17	4	415	4	C9orf135	9	72472845	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	55236383	72472845	68740586	62	10669											
ACTL7B	10880	broad.mit.edu	37	chr9	111617803	111617803	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcggggaggatcttcatggcGgtgcggaagatgtactccca	8	9	15	9	3	2	1	1	0	1	1	4	4	3	4	1	6	2	1	1	6	2	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:111617803G>A	uc004bdi.2	-	1	473	c.408C>T	c.(406-408)ACC>ACT	p.T136T		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	136						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TCTTCATGGCGGTGCGGAAGA	0.622													32	60					0	0	0	0	A	111617803	A	A	111617803	2	1	54	1	0	0	0	0	0	0	0	1	201	1103	39	1		1	ACTL7B	9	111617803	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08	39144958	111617803	29595628	63	10670											
SCAI	286205	broad.mit.edu	37	chr9	127765428	127765428	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagaaggtatatagctggcTgaaggttggtttgtagagca	12	12	14	3	0	0	3	0	1	0	2	0	3	0	3	0	4	2	7	0	4	7	7			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:127765428T>A	uc004bpe.2	-	11	1111	c.1030A>T	c.(1030-1032)AGC>TGC	p.S344C	SCAI_uc004bpd.2_Missense_Mutation_p.S367C|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	344					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						TATAGCTGGCTGAAGGTTGGT	0.383													193	340					0	0	0	0	A	127765428	A	A	127765428	3	1	54	1	0	0	0	0	1	0	0	0	13934	1580	55	5	822	5	SCAI	9	127765428	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08	16147625	127765428	13448003	64	10671											
NOTCH1	4851	broad.mit.edu	37	chr9	139401756	139401756	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctccgtgcagcggcccttaCcctgagtgccccgtgggcag	4	7	13	17	3	0	1	0	1	0	0	1	1	1	1	6	2	4	2	6	2	1	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr9:139401756C>T	uc004chz.2	-	22	3643	c.3643_splice	c.e22+1	p.G1215_splice	NOTCH1_uc004cia.1_Splice_Site_p.G445_splice	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein						aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCGGCCCTTACCCTGAGTGCC	0.692			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			24	49					0	0	0	0	T	139401756	T	T	139401756	5	4	54	1	0	0	0	0	0	0	1	0	10601	521	18	4	4075	4	NOTCH1	9	139401756	Splice_Site	SNP	C	TCGA-CN-5355-01A-01D-1434-08	11636328	139401756	1811675	65	10672											
RASSF4	83937	broad.mit.edu	37	chr10	45480280	45480280	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcccctggaggaggcagaGgaggccccccagctgatgcg	7	3	18	13	1	0	2	0	1	0	1	0	5	0	5	5	6	2	2	5	6	0	0			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:45480280G>A	uc001jbo.2	+	6	527	c.393G>A	c.(391-393)GAG>GAA	p.E131E	RASSF4_uc001jbp.2_Silent_p.E162E|RASSF4_uc009xmn.2_Silent_p.E61E|RASSF4_uc001jbq.2_Silent_p.E28E|RASSF4_uc001jbt.2_Silent_p.E88E	NM_032023	NP_114412	Q9H2L5	RASF4_HUMAN	Ras association domain family 4	131					cell cycle|signal transduction		protein binding			large_intestine(1)	1						AGGAGGCAGAGGAGGCCCCCC	0.667													26	205					0	0	0	0	A	45480280	A	A	45480280	2	1	54	1	0	0	0	0	0	0	0	1	13153	991	35	4		4	RASSF4	10	45480280	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08		45480280	90054467	66	10673											
ANUBL1	93550	broad.mit.edu	37	chr10	46121636	46121636	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atttctgtgatatcccgagcCtcaactttggaaataacatc	12	13	6	10	1	2	1	1	1	1	0	4	3	3	2	2	1	3	0	2	1	4	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:46121636C>T	uc001jcp.3	-	7	1877	c.1635G>A	c.(1633-1635)GAG>GAA	p.E545E	ANUBL1_uc001jcl.3_Silent_p.E65E|ANUBL1_uc001jcm.3_Silent_p.E545E|ANUBL1_uc009xmu.2_Silent_p.E471E|ANUBL1_uc001jcn.3_Silent_p.E471E|ANUBL1_uc001jco.3_Intron	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	545							zinc ion binding				0						TATCCCGAGCCTCAACTTTGG	0.398													45	165					0	0	0	0	T	46121636	T	T	46121636	2	4	54	1	0	0	0	0	0	0	0	1	713	680	24	4		4	ANUBL1	10	46121636	Silent	SNP	C	TCGA-CN-5355-01A-01D-1434-08	641356	46121636	89413111	67	10674											
BICC1	80114	broad.mit.edu	37	chr10	60546842	60546842	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagcagaaaaaagcaaccagGtggtttgtcttttcacatga	15	10	9	7	0	2	2	1	1	1	1	2	2	2	2	1	2	3	3	1	2	5	3			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:60546842G>C	uc001jki.1	+	5	546	c.546_splice	c.e5+1	p.Q182_splice		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1						multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						AAGCAACCAGGTGGTTTGTCT	0.353													5	72					0	0	0	0	C	60546842	C	C	60546842	5	2	54	1	0	0	0	0	0	0	1	0	1430	1275	44	4	565	4	BICC1	10	60546842	Splice_Site	SNP	G	TCGA-CN-5355-01A-01D-1434-08	14425206	60546842	74987905	68	10675											
BTAF1	9044	broad.mit.edu	37	chr10	93748998	93748998	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atagtaaacgacagcaggtcCaaatgacagttacagagacc	17	6	9	9	1	0	2	0	1	0	1	1	4	1	2	2	1	3	3	2	1	5	3			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr10:93748998C>A	uc001khr.2	+	20	2613	c.2515C>A	c.(2515-2517)CAA>AAA	p.Q839K	BTAF1_uc001khs.1_Missense_Mutation_p.Q509K|BTAF1_uc001kht.1_Missense_Mutation_p.Q277K	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	839	HEAT 5.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				ACAGCAGGTCCAAATGACAGT	0.418													10	78					7.48243e-07	8.27005e-07	1	0	A	93748998	A	A	93748998	3	1	54	1	0	0	0	0	1	0	0	0	1541	595	21	4	2593	4	BTAF1	10	93748998	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	33202156	93748998	41785749	69	10676											
OR52E4	390081	broad.mit.edu	37	chr11	5905705	5905705	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catagtctacaccagcccatGttctacttcctggccatgtt	8	13	6	14	0	2	0	0	0	2	0	3	0	3	0	4	1	3	2	4	1	3	6			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:5905705G>T	uc010qzs.1	+	1	183	c.183G>T	c.(181-183)ATG>ATT	p.M61I	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCAGCCCATGTTCTACTTCC	0.433													71	251					4.98926e-31	6.66746e-31	1	0	T	5905705	T	T	5905705	3	4	54	1	0	0	0	0	1	0	0	0	11170	1377	48	4	185	4	OR52E4	11	5905705	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08		5905705	129100811	70	10677											
CALCA	796	broad.mit.edu	37	chr11	14989331	14989331	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcaccacaccccctgatctGctcagcaagcctgccagccg	8	7	7	19	1	3	1	2	1	1	0	3	1	3	1	6	0	5	2	6	0	1	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:14989331G>T	uc001mlt.1	-	4	372	c.297C>A	c.(295-297)AGC>AGA	p.S99R	CALCA_uc001mlu.1_RNA	NM_001033953	NP_001029125	P06881	CALCA_HUMAN	calcitonin isoform CGRP preproprotein	99					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)	1					Phentolamine(DB00692)	CCCCTGATCTGCTCAGCAAGC	0.542													27	81					3.01185e-09	3.45892e-09	1	0	T	14989331	T	T	14989331	3	4	54	1	0	0	0	0	1	0	0	0	2587	1310	46	4	93	4	CALCA	11	14989331	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	9083626	14989331	120017185	71	10678											
DEPDC7	91614	broad.mit.edu	37	chr11	33054967	33054967	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcaattctataagtgtcAcccagacatctttattgagc	12	13	7	9	0	4	2	2	1	2	1	4	2	4	2	1	1	1	0	1	1	4	6			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:33054967A>T	uc001mub.2	+	9	1594	c.1502A>T	c.(1501-1503)CAC>CTC	p.H501L	DEPDC7_uc001muc.2_Missense_Mutation_p.H492L	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	501					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						TATAAGTGTCACCCAGACATC	0.299													35	108					0	0	0	0	T	33054967	T	T	33054967	3	4	54	1	0	0	0	0	1	0	0	0	4466	159	6	5	1586	5	DEPDC7	11	33054967	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	18065636	33054967	101951549	72	10679											
LRRC4C	57689	broad.mit.edu	37	chr11	40135934	40135934	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgttttagatttgagtctCttgtacattgtctttagagt	9	20	8	4	0	2	3	0	1	2	2	3	3	2	3	0	0	1	2	0	0	4	8			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:40135934C>G	uc001mxa.1	-	2	3873	c.1909G>C	c.(1909-1911)GAG>CAG	p.E637Q	LRRC4C_uc001mxc.1_Missense_Mutation_p.E633Q|LRRC4C_uc001mxd.1_Missense_Mutation_p.E633Q|LRRC4C_uc001mxb.1_Missense_Mutation_p.E633Q	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	637					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				ATTTGAGTCTCTTGTACATTG	0.259													18	97					0	0	0	0	G	40135934	G	G	40135934	3	3	54	1	0	0	0	0	1	0	0	0	9058	922	32	2	17	2	LRRC4C	11	40135934	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	7080967	40135934	94870582	73	10680											
SLC43A3	29015	broad.mit.edu	37	chr11	57176684	57176684	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgaagggagcctttgatgagGgtgaagatggggaactggag	11	8	19	3	0	0	5	0	4	0	1	0	8	0	8	1	5	2	0	1	5	3	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:57176684G>A	uc001nkg.2	-	13	1745	c.1335C>T	c.(1333-1335)ACC>ACT	p.T445T	PRG2_uc001nke.2_Intron|SLC43A3_uc001nkh.2_Silent_p.T445T|SLC43A3_uc010rjr.1_Silent_p.T458T|SLC43A3_uc009yme.2_Silent_p.T445T|SLC43A3_uc001nki.2_Silent_p.T445T	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	445	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)	1						CTTTGATGAGGGTGAAGATGG	0.567													45	168					0	0	0	0	A	57176684	A	A	57176684	2	1	54	1	0	0	0	0	0	0	0	1	14698	1219	43	4		4	SLC43A3	11	57176684	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08	17040750	57176684	77829832	74	10681											
NADSYN1	55191	broad.mit.edu	37	chr11	71185480	71185480	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccaaccagaagggttgtGacggggaccgcctgtactac	9	7	14	11	2	0	2	0	1	0	1	0	3	0	3	4	4	3	2	4	4	4	3			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:71185480G>T	uc001oqn.2	+	9	832	c.706G>T	c.(706-708)GAC>TAC	p.D236Y	NADSYN1_uc001oqm.2_RNA|NADSYN1_uc001oqo.2_5'UTR	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	236	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAAGGGTTGTGACGGGGACCG	0.557													18	132					5.45727e-16	6.74133e-16	1	0	T	71185480	T	T	71185480	3	4	54	1	0	0	0	0	1	0	0	0	10191	1290	45	2	740	2	NADSYN1	11	71185480	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	14008796	71185480	63821036	75	10682											
USP35	57558	broad.mit.edu	37	chr11	77921387	77921388	+	Frame_Shift_Ins	INS	-	C	C																															atcctggatgacgtctccatINSccccctgctgctccgcctgc																										TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:77921387_77921388insC	uc009yva.1	+	10	2732_2733	c.2486_2487insC	c.(2485-2487)ATCfs	p.I829fs	USP35_uc001oze.2_Frame_Shift_Ins_p.I585fs|USP35_uc001ozc.2_Frame_Shift_Ins_p.I397fs|USP35_uc010rsp.1_Frame_Shift_Ins_p.I261fs|USP35_uc001ozd.2_Frame_Shift_Ins_p.I440fs|USP35_uc001ozf.2_Frame_Shift_Ins_p.I560fs	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	829					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			GACGTCTCCATCCCCCTGCTGC	0.634													---	---	---								C	77921388	C	C	77921387	7	5	54	1	0	1	1	0	0	0	0	0	17134	1435	50	0	2520	0	USP35	11	77921387	Frame_Shift_Ins	INS	-	TCGA-CN-5355-01A-01D-1434-08	6735907	77921387	57085129	76	10683											
MTNR1B	4544	broad.mit.edu	37	chr11	92715080	92715080	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgctggtgcttcaggccCgcaggaaagccaagccagag	9	5	16	11	1	1	1	1	0	0	1	1	2	1	2	3	4	4	3	3	4	2	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:92715080C>T	uc001pdk.1	+	2	794	c.691C>T	c.(691-693)CGC>TGC	p.R231C		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	231	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GCTTCAGGCCCGCAGGAAAGC	0.582													21	127					0	0	0	0	T	92715080	T	T	92715080	3	4	54	1	0	0	0	0	1	0	0	0	10005	652	23	1	697	1	MTNR1B	11	92715080	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	14793693	92715080	42291436	77	10684											
BCL9L	283149	broad.mit.edu	37	chr11	118779003	118779003	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcctctgaatccagggatgGggtcccagcctctcgctgct	5	9	13	14	1	2	1	0	1	2	0	5	2	4	2	4	4	2	2	4	4	1	0			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:118779003G>A	uc001pug.2	-	2	1353	c.388C>T	c.(388-390)CCA>TCA	p.P130S	BCL9L_uc009zal.2_Missense_Mutation_p.P125S	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	130					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TCCAGGGATGGGGTCCCAGCC	0.592													21	98					0	0	0	0	A	118779003	A	A	118779003	3	1	54	1	0	0	0	0	1	0	0	0	1384	1232	43	4	4139	4	BCL9L	11	118779003	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	26063923	118779003	16227513	78	10685											
OR8D4	338662	broad.mit.edu	37	chr11	123777296	123777296	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaattattaggctgaatcGtcaacttcatacccccatgt	11	13	5	12	1	3	1	3	1	0	0	4	1	3	1	2	1	2	1	2	1	6	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:123777296G>A	uc010saa.1	+	1	158	c.158G>A	c.(157-159)CGT>CAT	p.R53H		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		AGGCTGAATCGTCAACTTCAT	0.408													58	282					0	0	0	0	A	123777296	A	A	123777296	3	1	54	1	0	0	0	0	1	0	0	0	11287	1145	40	1	160	1	OR8D4	11	123777296	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	4998293	123777296	11229220	79	10686											
IGSF9B	22997	broad.mit.edu	37	chr11	133815961	133815961	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgcccagaccttacctgcaTactcagggtccacgtgcggc	7	8	11	15	2	1	1	1	0	0	1	2	1	2	1	4	2	5	1	4	2	2	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr11:133815961T>A	uc001qgx.3	-	2	488	c.257A>T	c.(256-258)TAT>TTT	p.Y86F	IGSF9B_uc001qgz.2_RNA	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	86	Extracellular (Potential).|Ig-like 1.					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTTACCTGCATACTCAGGGTC	0.612													4	9					0	0	0	0	A	133815961	A	A	133815961	3	1	54	1	0	0	0	0	1	0	0	0	7645	1406	49	5	3864	5	IGSF9B	11	133815961	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08	10038665	133815961	1190555	80	10687											
SLC6A12	6539	broad.mit.edu	37	chr12	306025	306025	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catagtcacagccttggggaAggcgatgaaggccagcccag	11	5	14	11	1	1	1	1	1	0	0	1	3	1	2	3	4	2	0	3	4	3	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:306025A>C	uc001qhz.2	-	12	1642	c.1099T>G	c.(1099-1101)TTC>GTC	p.F367V	SLC6A12_uc001qhx.2_Missense_Mutation_p.F24V|SLC6A12_uc001qhy.2_Intron|SLC6A12_uc001qia.2_Missense_Mutation_p.F367V|SLC6A12_uc001qib.2_Missense_Mutation_p.F367V|SLC6A12_uc009zdh.1_Missense_Mutation_p.F367V	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	367					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			GCCTTGGGGAAGGCGATGAAG	0.582													14	73					0	0	0	0	C	306025	C	C	306025	3	2	54	1	0	0	0	0	1	0	0	0	14739	72	3	5	769	5	SLC6A12	12	306025	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08		306025	133545870	81	10688											
A2M	2	broad.mit.edu	37	chr12	9256907	9256907	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaaggccatgctcatccgtGgtagcattggagtaatagtt	11	11	11	8	1	1	0	1	0	0	0	2	1	2	1	2	3	2	5	2	3	4	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:9256907G>A	uc001qvk.1	-	11	1307	c.1194C>T	c.(1192-1194)ACC>ACT	p.T398T	A2M_uc009zgk.1_Silent_p.T248T	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	398					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GCTCATCCGTGGTAGCATTGG	0.413													8	31					0	0	0	0	A	9256907	A	A	9256907	2	1	54	1	0	0	0	0	0	0	0	1	4	1335	47	4		4	A2M	12	9256907	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08	8950882	9256907	124594988	82	10689											
ARID2	196528	broad.mit.edu	37	chr12	46244170	46244170	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacagggccacaacctgttaCagttgtgaattctcagacat	12	11	8	10	0	1	2	1	1	1	1	2	2	1	2	2	1	3	2	2	1	4	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:46244170C>T	uc001ros.1	+	15	2264	c.2264C>T	c.(2263-2265)ACA>ATA	p.T755I	ARID2_uc001ror.2_Missense_Mutation_p.T755I|ARID2_uc009zkg.1_Missense_Mutation_p.T211I|ARID2_uc009zkh.1_Missense_Mutation_p.T382I|ARID2_uc001rou.1_Missense_Mutation_p.T89I	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	755					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CAACCTGTTACAGTTGTGAAT	0.478													20	87					0	0	0	0	T	46244170	T	T	46244170	3	4	54	1	0	0	0	0	1	0	0	0	915	478	17	4	2322	4	ARID2	12	46244170	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	36987263	46244170	87607725	83	10690											
LRIG3	121227	broad.mit.edu	37	chr12	59274631	59274631	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaactcaaattggaacctttTattgccgactgtgtttctgg	10	15	8	8	1	2	0	1	0	1	0	2	2	2	1	2	2	3	1	2	2	4	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:59274631T>C	uc001sqr.2	-	13	1779	c.1533A>G	c.(1531-1533)ATA>ATG	p.I511M	LRIG3_uc009zqh.2_Missense_Mutation_p.I451M|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	511	Ig-like C2-type 1.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			TGGAACCTTTTATTGCCGACT	0.433													69	196					0	0	0	0	C	59274631	C	C	59274631	3	2	54	1	0	0	0	0	1	0	0	0	8996	1744	61	5	1854	5	LRIG3	12	59274631	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08	13030461	59274631	74577264	84	10691											
TRHDE	29953	broad.mit.edu	37	chr12	73014920	73014920	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagcaagttgcaacaacataTatcaagcttgggtggccgaa	15	8	10	8	1	1	0	1	0	0	0	1	1	1	0	1	2	5	4	1	2	8	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:73014920T>C	uc001sxa.2	+	14	2397	c.2367T>C	c.(2365-2367)TAT>TAC	p.Y789Y		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	789	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CAACAACATATATCAAGCTTG	0.313													25	82					0	0	0	0	C	73014920	C	C	73014920	2	2	54	1	0	0	0	0	0	0	0	1	16546	1413	49	5		5	TRHDE	12	73014920	Silent	SNP	T	TCGA-CN-5355-01A-01D-1434-08	13740289	73014920	60836975	85	10692											
TCP11L2	255394	broad.mit.edu	37	chr12	106717343	106717343	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acatggccaattttacaattAtgagtctcagaccgcacctt	12	12	6	11	1	1	2	1	1	1	1	2	2	1	2	3	1	1	1	3	1	4	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:106717343A>G	uc001tln.2	+	6	865	c.691A>G	c.(691-693)ATG>GTG	p.M231V	TCP11L2_uc001tll.2_Missense_Mutation_p.M231V|TCP11L2_uc001tlm.2_Missense_Mutation_p.M231V	NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	231										ovary(3)	3						TTTTACAATTATGAGTCTCAG	0.363													15	79					0	0	0	0	G	106717343	G	G	106717343	3	3	54	1	0	0	0	0	1	0	0	0	15781	449	16	5	709	5	TCP11L2	12	106717343	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	33702423	106717343	27134552	86	10693											
C12orf51	283450	broad.mit.edu	37	chr12	112617111	112617111	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagagactctgatgggcttcGctggtgtcaggctcagcgtc	6	10	14	11	2	3	2	2	1	1	1	5	3	3	2	0	3	1	3	0	3	0	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr12:112617111G>A	uc009zwc.2	-	56	9830	c.9812C>T	c.(9811-9813)GCG>GTG	p.A3271V		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GATGGGCTTCGCTGGTGTCAG	0.547													7	29					0	0	0	0	A	112617111	A	A	112617111	3	1	54	1	0	0	0	0	1	0	0	0	1702	1087	38	1	2234	1	C12orf51	12	112617111	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	5899768	112617111	21234784	87	10694											
TRPC4	7223	broad.mit.edu	37	chr13	38266248	38266248	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcagcaggaacaaaaaagtCaaataggaggctgtgtggca	17	5	13	6	0	1	0	1	0	0	0	1	2	1	2	0	4	3	4	0	4	6	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr13:38266248C>G	uc001uws.2	-	4	1357	c.1122G>C	c.(1120-1122)TTG>TTC	p.L374F	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Missense_Mutation_p.L374F|TRPC4_uc010tey.1_Missense_Mutation_p.L374F|TRPC4_uc010abw.2_Missense_Mutation_p.L201F|TRPC4_uc010abx.2_Missense_Mutation_p.L374F|TRPC4_uc010aby.2_Missense_Mutation_p.L374F	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	374	Helical; (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ACAAAAAAGTCAAATAGGAGG	0.483													18	65					0	0	0	0	G	38266248	G	G	38266248	3	3	54	1	0	0	0	0	1	0	0	0	16647	825	29	2	1858	2	TRPC4	13	38266248	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08		38266248	76903630	88	10695											
NALCN	259232	broad.mit.edu	37	chr13	101763549	101763549	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgcccctcaaatgatcCgctcagcatgcgctgtcggg	6	8	13	14	3	2	1	2	1	0	0	4	1	3	1	3	2	3	4	3	2	1	0			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr13:101763549C>T	uc001vox.1	-	19	2410	c.2221G>A	c.(2221-2223)GGA>AGA	p.G741R		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	741	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCAAATGATCCGCTCAGCATG	0.493													69	201					0	0	0	0	T	101763549	T	T	101763549	3	4	54	1	0	0	0	0	1	0	0	0	10201	661	23	1	3099	1	NALCN	13	101763549	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	63497301	101763549	13406329	89	10696											
KLHL28	54813	broad.mit.edu	37	chr14	45403630	45403630	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgatagtgacgccaggaCgcacattagttgcaatacca	12	10	9	10	2	1	2	0	2	1	0	1	3	1	3	2	1	2	3	2	1	4	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr14:45403630C>A	uc001wvq.2	-	3	1277	c.1031G>T	c.(1030-1032)CGT>CTT	p.R344L	KLHL28_uc001wvr.2_Missense_Mutation_p.R344L	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	344	Kelch 2.									ovary(1)	1						GACGCCAGGACGCACATTAGT	0.393													74	98					2.10328e-26	2.78543e-26	1	0	A	45403630	A	A	45403630	3	1	54	1	0	0	0	0	1	0	0	0	8421	536	19	3	696	3	KLHL28	14	45403630	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08		45403630	61945910	90	10697											
MDGA2	161357	broad.mit.edu	37	chr14	47426789	47426789	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactctgcaactcatagtgAcacttcgatcctgtccttgc	8	13	7	13	1	2	1	1	1	1	0	5	2	4	1	2	0	4	2	2	0	3	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr14:47426789A>C	uc001wwj.3	-	9	1866	c.1670T>G	c.(1669-1671)GTC>GGC	p.V557G	MDGA2_uc001wwi.3_Missense_Mutation_p.V328G|MDGA2_uc010ani.2_Missense_Mutation_p.V117G	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	557	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						ACTCATAGTGACACTTCGATC	0.458													28	118					0	0	0	0	C	47426789	C	C	47426789	3	2	54	1	0	0	0	0	1	0	0	0	9460	275	10	5	1236	5	MDGA2	14	47426789	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	2023159	47426789	59922751	91	10698											
MAGEL2	54551	broad.mit.edu	37	chr15	23890513	23890513	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcaggctgaaactgggaggTagctgggaagacacttgagg	11	6	18	6	0	0	3	0	2	0	1	0	5	0	5	0	6	2	4	0	6	3	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:23890513T>A	uc001ywj.3	-	1	663	c.568A>T	c.(568-570)ACC>TCC	p.T190S		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		AACTGGGAGGTAGCTGGGAAG	0.582													19	79					0	0	0	0	A	23890513	A	A	23890513	3	1	54	1	0	0	0	0	1	0	0	0	9242	1638	57	5	1376	5	MAGEL2	15	23890513	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08		23890513	78640879	92	10699											
MYO5A	4644	broad.mit.edu	37	chr15	52672048	52672048	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaaccggccgcactgattcgGatggtttccaggacaccaca	11	7	10	13	3	0	1	0	1	0	0	2	3	1	3	4	4	1	2	4	4	1	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:52672048G>A	uc002aby.2	-	17	2314	c.2070C>T	c.(2068-2070)ATC>ATT	p.I690I	MYO5A_uc002abx.3_Silent_p.I690I|MYO5A_uc010uge.1_Silent_p.I559I	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	690	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CACTGATTCGGATGGTTTCCA	0.473													43	190					0	0	0	0	A	52672048	A	A	52672048	2	1	54	1	0	0	0	0	0	0	0	1	10131	1164	41	2		2	MYO5A	15	52672048	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08	28781535	52672048	49859344	93	10700											
UNC13C	440279	broad.mit.edu	37	chr15	54919300	54919300	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaacaagatctactgaaGagagtgcttgaaacaaacac	18	7	8	8	0	1	5	0	3	1	2	1	6	1	5	0	0	5	1	0	0	6	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:54919300G>T	uc002ack.2	+	31	6634	c.6634G>T	c.(6634-6636)GAG>TAG	p.E2212*	UNC13C_uc002acm.2_Nonsense_Mutation_p.E133*	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	2212					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATCTACTGAAGAGAGTGCTTG	0.353													12	28					1.08611e-07	1.21876e-07	1	0	T	54919300	T	T	54919300	4	4	54	1	0	0	0	0	0	1	0	0	17054	943	33	2	6756	2	UNC13C	15	54919300	Nonsense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	2247252	54919300	47612092	94	10701											
VPS33B	26276	broad.mit.edu	37	chr15	91557072	91557072	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactttgtatttgcgagttcGgccagccaatttgtcagcat	8	14	9	10	2	1	0	1	0	0	0	2	1	1	0	2	1	3	3	2	1	2	5			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr15:91557072G>A	uc002bqp.1	-	5	673	c.319C>T	c.(319-321)CGA>TGA	p.R107*	VPS33B_uc002bqq.1_Nonsense_Mutation_p.R16*|VPS33B_uc010uqu.1_Nonsense_Mutation_p.R80*	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	107					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					TTGCGAGTTCGGCCAGCCAAT	0.493													40	146					0	0	0	0	A	91557072	A	A	91557072	4	1	54	1	0	0	0	0	0	1	0	0	17270	1124	39	1	1610	1	VPS33B	15	91557072	Nonsense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	36637772	91557072	10974320	95	10702											
SOLH	6650	broad.mit.edu	37	chr16	602492	602492	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtgctgcgccttcaaccActgggggccgcccctgccgg	3	7	15	16	3	1	0	1	0	0	0	1	0	1	0	6	4	4	1	6	4	1	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:602492A>T	uc002chi.2	+	11	3062	c.2699A>T	c.(2698-2700)CAC>CTC	p.H900L	SOLH_uc002chj.2_5'UTR	NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	900					proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				GCCTTCAACCACTGGGGGCCG	0.706													8	24					0	0	0	0	T	602492	T	T	602492	3	4	54	1	0	0	0	0	1	0	0	0	14989	159	6	5	2729	5	SOLH	16	602492	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08		602492	89752261	96	10703											
ACSM2B	348158	broad.mit.edu	37	chr16	20554262	20554262	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggacggggtctgggctgcTgatcacagccgtctcaacca	7	8	13	13	3	3	1	2	1	2	0	5	2	3	2	2	4	3	2	2	4	1	0			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:20554262T>G	uc002dhj.3	-	13	1693	c.1483A>C	c.(1483-1485)AGC>CGC	p.S495R	ACSM2B_uc002dhk.3_Missense_Mutation_p.S495R|ACSM2B_uc010bwf.1_Missense_Mutation_p.S495R	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	495					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TCTGGGCTGCTGATCACAGCC	0.483													18	92					0	0	0	0	G	20554262	G	G	20554262	3	3	54	1	0	0	0	0	1	0	0	0	184	1580	55	5	262	5	ACSM2B	16	20554262	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08	19951770	20554262	69800491	97	10704											
ZNF423	23090	broad.mit.edu	37	chr16	49671562	49671562	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggggccgcagtgggagaCgcggatgtgctcctgcaggc	5	7	19	10	3	0	1	0	0	0	1	1	3	1	2	2	5	2	4	2	5	0	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:49671562C>T	uc002efs.2	-	5	1799	c.1501G>A	c.(1501-1503)GTC>ATC	p.V501I	ZNF423_uc010vgn.1_Missense_Mutation_p.V384I	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	501	C2H2-type 11.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CAGTGGGAGACGCGGATGTGC	0.562													6	75					0	0	0	0	T	49671562	T	T	49671562	3	4	54	1	0	0	0	0	1	0	0	0	17965	536	19	1	2373	1	ZNF423	16	49671562	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	29117300	49671562	40683191	98	10705											
LPCAT2	54947	broad.mit.edu	37	chr16	55583314	55583314	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taaaattagccgaaaattgaAgtaagtgtattttaaaatga	19	13	7	2	1	0	2	0	2	0	0	0	3	0	2	1	0	1	2	1	0	10	7			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:55583314A>G	uc002eie.3	+	10	1242	c.1061A>G	c.(1060-1062)AAA>AGA	p.K354R	LPCAT2_uc002eic.2_Missense_Mutation_p.K84R	NM_017839	NP_060309	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	354	Lumenal (Potential).				cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0						CGAAAATTGAAGTAAGTGTAT	0.363													26	99					0	0	0	0	G	55583314	G	G	55583314	3	3	54	1	0	0	0	0	1	0	0	0	8961	86	3	5	1099	5	LPCAT2	16	55583314	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	5911752	55583314	34771439	99	10706											
EDC4	23644	broad.mit.edu	37	chr16	67911296	67911296	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtggcgcttggctctggttAatggcaaaattcagtatcca	9	13	11	8	1	2	0	1	0	1	0	3	0	3	0	1	4	0	5	1	4	4	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:67911296A>T	uc002eur.2	+	5	794	c.628A>T	c.(628-630)AAT>TAT	p.N210Y	EDC4_uc010cer.2_5'UTR|EDC4_uc010vkg.1_Missense_Mutation_p.N142Y|EDC4_uc010ces.1_Missense_Mutation_p.N53Y|EDC4_uc002eus.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	210	WD 1.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		GGCTCTGGTTAATGGCAAAAT	0.567													25	65					0	0	0	0	T	67911296	T	T	67911296	3	4	54	1	0	0	0	0	1	0	0	0	4930	362	13	5	646	5	EDC4	16	67911296	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	12327982	67911296	22443457	100	10707											
FOXC2	2303	broad.mit.edu	37	chr16	86601397	86601397	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaccctggacccggactcCtacaacatgttcgagaacgg	10	7	11	13	3	0	1	0	0	0	1	2	5	1	4	3	4	3	1	3	4	3	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr16:86601397C>A	uc002fjq.2	+	1	541	c.456C>A	c.(454-456)TCC>TCA	p.S152S		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	152	Fork-head.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						ACCCGGACTCCTACAACATGT	0.627									Late-onset_Hereditary_Lymphedema				30	98					1.74807e-11	2.03941e-11	1	0	A	86601397	A	A	86601397	2	1	54	1	0	0	0	0	0	0	0	1	6027	668	24	4		4	FOXC2	16	86601397	Silent	SNP	C	TCGA-CN-5355-01A-01D-1434-08	18690101	86601397	3753356	101	10708											
TP53	7157	broad.mit.edu	37	chr17	7576853	7576853	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtcccaagacttagtacCtgaagggtgaaatattctcc	12	10	10	9	0	1	3	0	2	1	1	3	4	2	3	3	2	1	1	3	2	6	4	rs11575996		TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:7576853C>T	uc002gim.2	-	9	1187	c.993G>A	c.(991-993)CAG>CAA	p.Q331Q	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Silent_p.Q331Q|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Silent_p.Q199Q|TP53_uc010cng.1_Silent_p.Q199Q|TP53_uc002gii.1_Silent_p.Q199Q|TP53_uc010cnh.1_Silent_p.Q331Q|TP53_uc010cni.1_Silent_p.Q331Q|TP53_uc002gij.2_Silent_p.Q331Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	331	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(14)|p.0?(7)|p.Q331P(3)|p.Q331fs*6(1)|p.I332fs*49(1)|p.?(1)|p.Q331Q(1)|p.Q331R(1)|p.Q331H(1)|p.Q331fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACTTAGTACCTGAAGGGTGA	0.453		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			56	79					0	0	0	0	T	7576853	T	T	7576853	2	4	54	1	0	0	0	0	0	0	0	1	16448	695	24	4		4	TP53	17	7576853	Silent	SNP	C	TCGA-CN-5355-01A-01D-1434-08		7576853	73618357	102	10709											
KDM6B	23135	broad.mit.edu	37	chr17	7755572	7755572	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgacccggagacctcgtGtggattaatgcggggactgt	8	8	15	10	4	0	1	0	0	0	1	1	5	0	3	2	4	2	0	2	4	1	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:7755572G>A	uc002giw.1	+	19	4762	c.4386G>A	c.(4384-4386)GTG>GTA	p.V1462V	KDM6B_uc002gix.2_Silent_p.V764V|TMEM88_uc002giy.2_5'Flank	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1462	JmjC.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						GAGACCTCGTGTGGATTAATG	0.607											OREG0024145	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	106					0	0	0	0	A	7755572	A	A	7755572	2	1	54	1	0	0	0	0	0	0	0	1	8177	1364	48	4		4	KDM6B	17	7755572	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08	178719	7755572	73439638	103	10710											
CHD3	1107	broad.mit.edu	37	chr17	7801355	7801355	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccatatgaccagtccacGtgggaggaagatgaaatgaa	15	8	11	7	1	0	4	0	3	0	1	1	6	1	6	3	2	1	0	3	2	5	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:7801355G>T	uc002gje.2	+	12	2136	c.1986G>T	c.(1984-1986)ACG>ACT	p.T662T	CHD3_uc002gjd.2_Silent_p.T721T|CHD3_uc002gjf.2_Silent_p.T662T|CHD3_uc002gjg.1_Silent_p.T490T	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	662	Chromo 2.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				ACCAGTCCACGTGGGAGGAAG	0.483													31	169					3.17567e-06	3.45795e-06	1	0	T	7801355	T	T	7801355	2	4	54	1	0	0	0	0	0	0	0	1	3341	1132	40	3		3	CHD3	17	7801355	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08	45783	7801355	73393855	104	10711											
PIK3R5	23533	broad.mit.edu	37	chr17	8792082	8792082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agagcagggaatctctctcgGcacagtgcccgtcagtttcc	8	9	11	13	2	3	1	1	0	2	1	6	2	4	2	2	2	2	3	2	2	1	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:8792082G>A	uc002glt.2	-	10	1089	c.1022C>T	c.(1021-1023)GCC>GTC	p.A341V	PIK3R5_uc010vuz.1_Missense_Mutation_p.A341V|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Missense_Mutation_p.P290S|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	341				DILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGH CAERDSLLSTSSLASHDSTLSLASSQASG -> GNIEGDPG PRRPDSAGLASLQTSCRKSCSRNRSYSSQGSWEMMKRRERR RRRWRRTWKLTGTVPREIPCS (in Ref. 6; AAW63121).	platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						ATCTCTCTCGGCACAGTGCCC	0.502													3	36					0	0	0	0	A	8792082	A	A	8792082	3	1	54	1	0	0	0	0	1	0	0	0	11977	1203	42	4	1660	4	PIK3R5	17	8792082	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	990727	8792082	72403128	105	10712											
CCL1	6346	broad.mit.edu	37	chr17	32688914	32688914	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catctggagaagggtacctgCactagaagaggaacacagac	15	5	12	9	0	1	4	0	0	1	4	1	6	1	5	1	3	3	2	1	3	5	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:32688914C>T	uc002hid.1	-	2	150	c.78G>A	c.(76-78)ATG>ATA	p.M26I		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	26					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		AGGGTACCTGCACTAGAAGAG	0.453											OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	130					0	0	0	0	T	32688914	T	T	32688914	3	4	54	1	0	0	0	0	1	0	0	0	2895	724	25	4	220	4	CCL1	17	32688914	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	23896832	32688914	48506296	106	10713											
KRT16	3868	broad.mit.edu	37	chr17	39767694	39767694	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtcagctcatccaacaccCggcgcaggccattgacgtcg	8	6	12	15	4	2	1	2	1	0	0	4	1	3	1	3	3	2	2	3	3	1	1	rs142812826	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:39767694C>A	uc002hxg.3	-	3	813	c.674G>T	c.(673-675)CGG>CTG	p.R225L	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	225	Coil 1B.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				ATCCAACACCCGGCGCAGGCC	0.622													25	101					4.87955e-14	5.78463e-14	1	0	A	39767694	A	A	39767694	3	1	54	1	0	0	0	0	1	0	0	0	8492	652	23	3	771	3	KRT16	17	39767694	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	7078780	39767694	41427516	107	10714											
WNK4	65266	broad.mit.edu	37	chr17	40948502	40948502	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccatcctgctcccaggcaTcatgcgaaggaactctctga	9	8	8	16	1	2	1	1	1	1	0	5	3	4	2	4	2	3	2	4	2	2	0			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:40948502T>A	uc002ibj.2	+	18	3656	c.3635T>A	c.(3634-3636)ATC>AAC	p.I1212N	WNK4_uc010wgx.1_Missense_Mutation_p.I876N|CCDC56_uc010wgz.1_Intron|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1212					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CTCCCAGGCATCATGCGAAGG	0.647													22	67					0	0	0	0	A	40948502	A	A	40948502	3	1	54	1	0	0	0	0	1	0	0	0	17448	1435	50	5	3705	5	WNK4	17	40948502	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08	1180808	40948502	40246708	108	10715											
CSH2	1443	broad.mit.edu	37	chr17	61952943	61952944	+	5'Flank	DEL	TC	-	-																															tctttctttctttctttcttTctttctttctttctttcttt																										TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr17:61952943_61952944delTC	uc002jch.2	-						CSH2_uc002jcg.2_5'Flank|CSH2_uc002jci.2_5'Flank|GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Intron	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1						female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						tttctttctttctttctttctt	0													---	---	---								-	61952944	-	-	61952943	6	5	54	0	1	1	0	1	0	0	0	0	3958	1798	62	0		0	CSH2	17	61952943	5'Flank	DEL	TC	TCGA-CN-5355-01A-01D-1434-08	21004441	61952943	19242267	109	10716											
POLI	11201	broad.mit.edu	37	chr18	51800403	51800403	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aagaaaagtgtccacagttgGtattagttaatggagaagac	16	10	11	4	0	0	3	0	0	0	3	1	4	1	3	1	2	0	3	1	2	7	4	rs142974796	byFrequency	TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr18:51800403G>T	uc002lfj.3	+	3	417	c.349G>T	c.(349-351)GTA>TTA	p.V117L	POLI_uc010xds.1_Missense_Mutation_p.V117L|POLI_uc002lfk.3_Missense_Mutation_p.V14L|POLI_uc002lfl.1_Missense_Mutation_p.V49L	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	117	UmuC.				DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		TCCACAGTTGGTATTAGTTAA	0.348								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					11	27					3.03607e-14	3.62848e-14	1	0	T	51800403	T	T	51800403	3	4	54	1	0	0	0	0	1	0	0	0	12258	1261	44	4	359	4	POLI	18	51800403	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08		51800403	26276845	110	10717											
ZNF236	7776	broad.mit.edu	37	chr18	74671751	74671751	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaaaccaagccagctggagCgccacagccgcatacataca	14	3	8	16	2	0	0	0	0	0	0	0	1	0	1	5	1	7	2	5	1	4	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr18:74671751C>G	uc002lmi.2	+	29	5413	c.5215C>G	c.(5215-5217)CGC>GGC	p.R1739G	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1739	C2H2-type 28.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCAGCTGGAGCGCCACAGCCG	0.502													14	65					0	0	0	0	G	74671751	G	G	74671751	3	3	54	1	0	0	0	0	1	0	0	0	17856	768	27	3	5329	3	ZNF236	18	74671751	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	22871348	74671751	3405497	111	10718											
ZNF536	9745	broad.mit.edu	37	chr19	30936347	30936347	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcagggtcctgggaacatGaaggagaagcccaccgagtg	11	5	15	10	1	0	2	0	1	0	1	1	5	1	3	3	3	3	1	3	3	3	0			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:30936347G>A	uc002nsu.1	+	2	2016	c.1878G>A	c.(1876-1878)ATG>ATA	p.M626I	ZNF536_uc010edd.1_Missense_Mutation_p.M626I	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	626					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CTGGGAACATGAAGGAGAAGC	0.597													58	222					0	0	0	0	A	30936347	A	A	30936347	3	1	54	1	0	0	0	0	1	0	0	0	18041	1290	45	2	1880	2	ZNF536	19	30936347	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08		30936347	28192636	112	10719											
ZNF83	55769	broad.mit.edu	37	chr19	53116711	53116711	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacacttataaggtttctcAccggcatgaattatcagatg	12	13	7	9	1	3	2	3	1	1	1	4	2	3	2	1	2	0	2	1	2	4	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:53116711A>G	uc002pzu.3	-	2	2351	c.1107T>C	c.(1105-1107)GGT>GGC	p.G369G	ZNF83_uc002pzv.3_Silent_p.G369G|ZNF83_uc010eps.2_Silent_p.G341G|ZNF83_uc010ept.2_Silent_p.G369G|ZNF83_uc010epu.2_Silent_p.G369G|ZNF83_uc010epv.2_Silent_p.G369G|ZNF83_uc010epw.2_Silent_p.G369G|ZNF83_uc010epx.2_Silent_p.G341G|ZNF83_uc010epy.2_Silent_p.G369G|ZNF83_uc010epz.2_Silent_p.G341G	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	369						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		AAGGTTTCTCACCGGCATGAA	0.393													57	199					0	0	0	0	G	53116711	G	G	53116711	2	3	54	1	0	0	0	0	0	0	0	1	18250	146	6	5		5	ZNF83	19	53116711	Silent	SNP	A	TCGA-CN-5355-01A-01D-1434-08	22180364	53116711	6012272	113	10720											
LILRB2	10288	broad.mit.edu	37	chr19	54780728	54780728	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggaggaggaggaggaggagCagtaggacgacggccaccaa	14	1	19	7	2	0	0	0	0	0	0	0	8	0	7	2	8	1	2	2	8	2	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:54780728C>G	uc002qfb.2	-	10	1682	c.1416G>C	c.(1414-1416)CTG>CTC	p.L472L	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Silent_p.L472L|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Silent_p.L471L|LILRB2_uc010yet.1_Silent_p.L356L	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	472	Helical; (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ggaggaggagcagtaggaCGA	0.453													36	124					0	0	0	0	G	54780728	G	G	54780728	2	3	54	1	0	0	0	0	0	0	0	1	8832	697	25	4		4	LILRB2	19	54780728	Silent	SNP	C	TCGA-CN-5355-01A-01D-1434-08	1664017	54780728	4348255	114	10721											
ZIK1	284307	broad.mit.edu	37	chr19	58102416	58102416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttataagtgtggtgactgtGggaaatcctttagtcaaagc	11	13	11	6	0	1	1	1	1	0	0	2	2	2	2	1	2	1	0	1	2	5	4			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:58102416G>A	uc002qpg.2	+	4	1334	c.1237G>A	c.(1237-1239)GGG>AGG	p.G413R	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Missense_Mutation_p.G358R|ZIK1_uc002qpi.2_Missense_Mutation_p.G400R|ZIK1_uc002qpj.2_Missense_Mutation_p.G310R	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	413	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGGTGACTGTGGGAAATCCTT	0.458													16	77					0	0	0	0	A	58102416	A	A	58102416	3	1	54	1	0	0	0	0	1	0	0	0	17750	1348	47	4	1251	4	ZIK1	19	58102416	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	3321688	58102416	1026567	115	10722											
ZNF418	147686	broad.mit.edu	37	chr19	58438767	58438767	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taaaagatttcccacattctCcacattcataaggtcttttc	12	15	3	11	0	3	1	1	0	2	1	6	1	4	1	2	1	0	0	2	1	3	7			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr19:58438767C>A	uc002qqs.1	-	4	1074	c.782G>T	c.(781-783)GGA>GTA	p.G261V	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.G176V	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	261	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CCCACATTCTCCACATTCATA	0.418													15	210					1.3612e-06	1.49326e-06	1	0	A	58438767	A	A	58438767	3	1	54	1	0	0	0	0	1	0	0	0	17962	855	30	2	1252	2	ZNF418	19	58438767	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	336351	58438767	690216	116	10723											
SIRPD	128646	broad.mit.edu	37	chr20	1532406	1532406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttccttttatgaacttcaCgcagtaataggtgccagcat	10	14	7	10	1	2	1	1	1	1	0	3	1	3	1	2	1	3	3	2	1	4	6			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr20:1532406C>T	uc002wfi.2	-	2	396	c.352G>A	c.(352-354)GTG>ATG	p.V118M		NM_178460	NP_848555	Q9H106	SIRPD_HUMAN	signal-regulatory protein delta precursor	118	Ig-like V-type.					extracellular region				ovary(1)|kidney(1)|skin(1)	3						ATGAACTTCACGCAGTAATAG	0.488													22	100					0	0	0	0	T	1532406	T	T	1532406	3	4	54	1	0	0	0	0	1	0	0	0	14400	536	19	1	253	1	SIRPD	20	1532406	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08		1532406	61493114	117	10724											
KRTAP13-3	337960	broad.mit.edu	37	chr21	31798152	31798152	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgctggggtaggaagagcCacaggaggagcctgggtagt	9	7	19	6	0	0	1	0	0	0	1	0	4	0	4	2	6	3	4	2	6	3	3			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr21:31798152C>A	uc002yob.1	-	1	79	c.79G>T	c.(79-81)GGC>TGC	p.G27C		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	27						intermediate filament				ovary(1)|lung(1)	2						TAGGAAGAGCCACAGGAGGAG	0.567													34	136					2.20474e-14	2.65653e-14	1	0	A	31798152	A	A	31798152	3	1	54	1	0	0	0	0	1	0	0	0	8563	594	21	4	443	4	KRTAP13-3	21	31798152	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08		31798152	16331743	118	10725											
ZNF295	49854	broad.mit.edu	37	chr21	43413874	43413875	+	Frame_Shift_Ins	INS	-	C	C																															atgttagtcagaaaggaaatINScccaagactatagccaagtt																										TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr21:43413874_43413875insC	uc002zab.3	-	3	544_545	c.330_331insG	c.(328-333)GGGATTfs	p.G110fs	ZNF295_uc002yzz.3_Frame_Shift_Ins_p.G110fs|ZNF295_uc002yzy.3_Frame_Shift_Ins_p.G110fs|ZNF295_uc002zaa.3_Frame_Shift_Ins_p.G110fs|ZNF295_uc010gov.1_Frame_Shift_Ins_p.G110fs|ZNF295_uc002zac.2_Frame_Shift_Ins_p.G110fs	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	110_111					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						AGAAAGGAAATCCCAAGACTAT	0.376													---	---	---								C	43413875	C	C	43413874	7	5	54	1	0	1	1	0	0	0	0	0	17894	1435	50	0	2873	0	ZNF295	21	43413874	Frame_Shift_Ins	INS	-	TCGA-CN-5355-01A-01D-1434-08	11615722	43413874	4716021	119	10726											
CCT8L2	150160	broad.mit.edu	37	chr22	17072997	17072997	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagattggatggccagggaGggcagtgtggccaggacctc	9	6	18	8	0	0	1	0	0	0	1	1	5	0	4	3	6	0	1	3	6	0	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:17072997G>A	uc002zlp.1	-	1	704	c.444C>T	c.(442-444)CCC>CCT	p.P148P		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	148					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGGCCAGGGAGGGCAGTGTGG	0.637													8	48					0	0	0	0	A	17072997	A	A	17072997	2	1	54	1	0	0	0	0	0	0	0	1	2976	987	35	4		4	CCT8L2	22	17072997	Silent	SNP	G	TCGA-CN-5355-01A-01D-1434-08		17072997	34231569	120	10727											
C22orf31	25770	broad.mit.edu	37	chr22	29454807	29454807	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggctgcttcctgccagggaAccggtccctctgagcacctt	5	10	11	15	1	1	1	0	1	1	0	3	2	3	2	5	3	4	3	5	3	1	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:29454807A>C	uc003aej.1	-	3	923	c.796T>G	c.(796-798)TTC>GTC	p.F266V		NM_015370	NP_056185	O95567	CV031_HUMAN	hypothetical protein LOC25770	266											0						CTGCCAGGGAACCGGTCCCTC	0.522													17	154					0	0	0	0	C	29454807	C	C	29454807	3	2	54	1	0	0	0	0	1	0	0	0	2153	43	2	5	80	5	C22orf31	22	29454807	Missense_Mutation	SNP	A	TCGA-CN-5355-01A-01D-1434-08	12381810	29454807	21849759	121	10728											
APOBEC3B	9582	broad.mit.edu	37	chr22	39385564	39385564	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgaggtggagcgcctggaCaatggcacctgggtcctgat	8	9	15	9	1	0	2	0	2	0	0	1	4	1	4	3	5	1	1	3	5	2	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:39385564C>A	uc003awo.1	+	5	726	c.672C>A	c.(670-672)GAC>GAA	p.D224E	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Missense_Mutation_p.D224E|APOBEC3B_uc003awq.1_Intron|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	224					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					AGCGCCTGGACAATGGCACCT	0.562													17	70					1.67942e-08	1.91375e-08	1	0	A	39385564	A	A	39385564	3	1	54	1	0	0	0	0	1	0	0	0	790	477	17	4	690	4	APOBEC3B	22	39385564	Missense_Mutation	SNP	C	TCGA-CN-5355-01A-01D-1434-08	9930757	39385564	11919002	122	10729											
APOBEC3D	140564	broad.mit.edu	37	chr22	39427930	39427930	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagattaccaggaggggctcTgcagcctgagtcaggaaggg	10	6	16	9	0	2	2	1	1	1	1	2	4	2	4	2	5	3	2	2	5	2	1			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:39427930T>C	uc011aoe.1	+	6	1048	c.994T>C	c.(994-996)TGC>CGC	p.C332R	APOBEC3D_uc011aof.1_Missense_Mutation_p.C148R|APOBEC3D_uc003awu.3_Missense_Mutation_p.C148R|APOBEC3D_uc003awt.3_Missense_Mutation_p.C332R|APOBEC3D_uc010gxu.2_Missense_Mutation_p.C128R	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	332					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					GGAGGGGCTCTGCAGCCTGAG	0.617													11	139					0	0	0	0	C	39427930	C	C	39427930	3	2	54	1	0	0	0	0	1	0	0	0	792	1580	55	5	1016	5	APOBEC3D	22	39427930	Missense_Mutation	SNP	T	TCGA-CN-5355-01A-01D-1434-08	42366	39427930	11876636	123	10730											
SCUBE1	80274	broad.mit.edu	37	chr22	43617226	43617226	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgctcgtgcctggctgtggGgccggaggtggcacttggca	3	10	18	10	2	0	0	0	0	0	0	1	1	0	1	2	7	2	4	2	7	0	2			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chr22:43617226G>C	uc003bdt.1	-	13	1590	c.1502C>G	c.(1501-1503)CCC>CGC	p.P501R		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	501					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				CTGGCTGTGGGGCCGGAGGTG	0.642													18	56					0	0	0	0	C	43617226	C	C	43617226	3	2	54	1	0	0	0	0	1	0	0	0	14009	1232	43	4	1504	4	SCUBE1	22	43617226	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08	4189296	43617226	7687340	124	10731											
KDM6A	7403	broad.mit.edu	37	chrX	44929602	44929602	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaagttctgaaggcatgcaGgttagtgtgggaaagttcat	12	11	14	4	0	2	2	1	1	1	1	2	3	2	3	0	3	1	5	0	3	4	3			TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chrX:44929602G>T	uc004dge.3	+	17	3077	c.2702G>T	c.(2701-2703)AGG>ATG	p.R901M	KDM6A_uc010nhk.2_Missense_Mutation_p.R867M|KDM6A_uc011mkz.1_Missense_Mutation_p.R953M|KDM6A_uc011mla.1_Missense_Mutation_p.R856M|KDM6A_uc011mlb.1_Missense_Mutation_p.R908M|KDM6A_uc011mlc.1_Missense_Mutation_p.R605M|KDM6A_uc011mld.1_Missense_Mutation_p.R540M	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	901					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AAGGCATGCAGGTTAGTGTGG	0.418			D|N|F|S		renal|oesophageal SCC|MM								9	13					4.68919e-08	5.30239e-08	1	0	T	44929602	T	T	44929602	3	4	54	1	0	0	0	0	1	0	0	0	8176	1014	35	4	2768	4	KDM6A	23	44929602	Missense_Mutation	SNP	G	TCGA-CN-5355-01A-01D-1434-08		44929602	110340958	125	10732											
SLITRK4	139065	broad.mit.edu	37	chrX	142718162	142718163	+	Frame_Shift_Ins	INS	-	T	T																															agctcttgtttgttggtttcINSttttaaaagccttccatata																										TCGA-CN-5355-01A-01D-1434-08	TCGA-CN-5355-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d93e8bc-69d5-47aa-b4bb-bf7b0ade92d6	247f6eb8-26da-4232-ba2d-eba32e4098ae	g.chrX:142718162_142718163insT	uc004fbx.2	-	2	1138_1139	c.762_763insA	c.(760-765)AAAGAAfs	p.K254fs	SLITRK4_uc004fby.2_Frame_Shift_Ins_p.K254fs	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	254_255	Extracellular (Potential).|LRRCT 1.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTGTTGGTTTCTTTTAAAAGCC	0.45													---	---	---								T	142718163	T	T	142718162	7	5	54	1	0	1	1	0	0	0	0	0	14809	922	32	0	1754	0	SLITRK4	23	142718162	Frame_Shift_Ins	INS	-	TCGA-CN-5355-01A-01D-1434-08	97788560	142718162	12552398	126	10733											
CDK11B	984	broad.mit.edu	37	chr1	1572346	1572346	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggggatccgtactcccgCgccagcccgaagtcacccac	9	4	11	17	4	1	1	1	0	0	1	3	3	3	2	5	2	2	1	5	2	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:1572346C>T	uc001agv.1	-	20	1824	c.1713G>A	c.(1711-1713)GCG>GCA	p.A571A	CDK11B_uc009vkj.2_Silent_p.A228A|CDK11B_uc001ags.1_Silent_p.A429A|CDK11B_uc001agt.1_Silent_p.A354A|CDK11B_uc001aha.1_Silent_p.A537A|CDK11B_uc001agw.1_Silent_p.A526A|CDK11B_uc001agy.1_Silent_p.A569A|CDK11B_uc001agx.1_Silent_p.A560A|CDK11B_uc001agz.1_Silent_p.A315A	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	584	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CGTACTCCCGCGCCAGCCCGA	0.687													15	21					0	0	0	0	T	1572346	T	T	1572346	2	4	55	1	0	0	0	0	0	0	0	1	3142	755	27	1		1	CDK11B	1	1572346	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08		1572346	247678275	1	10734											
CELA2B	51032	broad.mit.edu	37	chr1	15813844	15813844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgggaggtgcatggcatcgGcagcctcacgtcggtccttg	5	9	16	11	3	1	0	1	0	0	0	4	1	2	1	2	5	2	3	2	5	0	1	rs141194336	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:15813844G>A	uc001awl.2	+	7	729	c.704G>A	c.(703-705)GGC>GAC	p.G235D		NM_015849	NP_056933	P08218	CEL2B_HUMAN	elastase 2B preproprotein	235	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						CATGGCATCGGCAGCCTCACG	0.577													4	109					0	0	0	0	A	15813844	A	A	15813844	3	1	55	1	0	0	0	0	1	0	0	0	3227	1203	42	4	730	4	CELA2B	1	15813844	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	14241498	15813844	233436777	2	10735											
ZBTB17	7709	broad.mit.edu	37	chr1	16272657	16272657	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catctgactcaccgctggccGcactctgggcctgaccgccg	5	7	11	18	4	3	2	1	2	2	0	3	2	3	2	5	2	0	2	5	2	0	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:16272657G>A	uc001axl.3	-	5	766	c.527C>T	c.(526-528)GCG>GTG	p.A176V	ZBTB17_uc010obq.1_Missense_Mutation_p.A93V|ZBTB17_uc010obr.1_Missense_Mutation_p.A176V|ZBTB17_uc010obs.1_Missense_Mutation_p.A100V|ZBTB17_uc010obt.1_Missense_Mutation_p.A113V|ZBTB17_uc010obu.1_Missense_Mutation_p.A100V|ZBTB17_uc009vom.1_Missense_Mutation_p.A119V|ZBTB17_uc010obv.1_Missense_Mutation_p.A176V	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	176					negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		ACCGCTGGCCGCACTCTGGGC	0.687													4	145					0	0	0	0	A	16272657	A	A	16272657	3	1	55	1	0	0	0	0	1	0	0	0	17594	1087	38	1	1932	1	ZBTB17	1	16272657	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	458813	16272657	232977964	3	10736											
BAI2	576	broad.mit.edu	37	chr1	32221927	32221927	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgggcgccagcaggcGcggggcctcggagggctcag	5	2	21	13	5	1	0	1	0	0	0	2	1	1	1	2	7	2	3	2	7	0	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:32221927G>T	uc001btn.2	-	4	865	c.511C>A	c.(511-513)CGC>AGC	p.R171S	BAI2_uc010ogp.1_Missense_Mutation_p.R159S|BAI2_uc010ogq.1_Missense_Mutation_p.R171S|BAI2_uc001bto.2_Missense_Mutation_p.R171S|BAI2_uc001btq.1_Missense_Mutation_p.R159S|BAI2_uc010ogr.1_Missense_Mutation_p.R159S	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	171	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GCCAGCAGGCGCGGGGCCTCG	0.622													9	76					0.000442599	0.000464305	1	0	T	32221927	T	T	32221927	3	4	55	1	0	0	0	0	1	0	0	0	1301	1087	38	3	4366	3	BAI2	1	32221927	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	15949270	32221927	217028694	4	10737											
TEKT2	27285	broad.mit.edu	37	chr1	36552864	36552864	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgccttcaggaagcggctGcgggagatggagaaagtgta	10	9	16	6	2	1	2	1	0	0	2	1	5	1	3	1	4	3	2	1	4	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:36552864G>T	uc001bzr.2	+	7	934	c.807G>T	c.(805-807)CTG>CTT	p.L269L	TEKT2_uc001bzs.2_Silent_p.L175L|ADPRHL2_uc001bzt.2_5'Flank|ADPRHL2_uc001bzu.2_5'Flank	NM_014466	NP_055281	Q9UIF3	TEKT2_HUMAN	tektin 2	269	Potential.				cell projection organization|microtubule cytoskeleton organization	actin cytoskeleton|cilium axoneme|flagellar axoneme|focal adhesion|microtubule|nucleolus					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGAAGCGGCTGCGGGAGATGG	0.542													13	50					2.61681e-11	2.98718e-11	1	0	T	36552864	T	T	36552864	2	4	55	1	0	0	0	0	0	0	0	1	15819	1306	46	4		4	TEKT2	1	36552864	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4330937	36552864	212697757	5	10738											
SLC6A9	6536	broad.mit.edu	37	chr1	44467985	44467985	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccagcagggagcactcacCggtaacagttattgtggaac	11	7	12	11	1	1	0	1	0	0	0	1	2	1	2	2	3	4	4	2	3	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:44467985C>T	uc001cll.2	-	8	1373	c.1181G>A	c.(1180-1182)CGG>CAG	p.R394Q	SLC6A9_uc009vxe.2_Missense_Mutation_p.R250Q|SLC6A9_uc010okm.1_Missense_Mutation_p.R321Q|SLC6A9_uc001clm.2_Missense_Mutation_p.R340Q|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Missense_Mutation_p.R325Q|SLC6A9_uc001cln.2_Missense_Mutation_p.R321Q|SLC6A9_uc010oko.1_Missense_Mutation_p.R210Q|SLC6A9_uc010okp.1_RNA	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	394						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GAGCACTCACCGGTAACAGTT	0.607													12	74					0	0	0	0	T	44467985	T	T	44467985	3	4	55	1	0	0	0	0	1	0	0	0	14755	666	23	1	967	1	SLC6A9	1	44467985	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	7915121	44467985	204782636	6	10739											
DAB1	1600	broad.mit.edu	37	chr1	57537304	57537304	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatctctcaagtccagaataAcaggttcagcctgggatgaa	13	9	10	9	0	3	2	2	1	1	1	5	4	4	3	2	2	2	1	2	2	4	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:57537304A>G	uc001cys.1	-	8	1123	c.449T>C	c.(448-450)GTT>GCT	p.V150A	DAB1_uc001cyt.1_Missense_Mutation_p.V150A|DAB1_uc001cyq.1_Missense_Mutation_p.V150A|DAB1_uc001cyr.1_Intron|DAB1_uc009vzw.1_Missense_Mutation_p.V150A|DAB1_uc009vzx.1_Missense_Mutation_p.V150A	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	150	PID.				cell differentiation|nervous system development					skin(2)|ovary(1)	3						GTCCAGAATAACAGGTTCAGC	0.418													21	48					0	0	0	0	G	57537304	G	G	57537304	3	3	55	1	0	0	0	0	1	0	0	0	4234	43	2	5	1254	5	DAB1	1	57537304	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	13069319	57537304	191713317	7	10740											
LRRC7	57554	broad.mit.edu	37	chr1	70555441	70555441	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatagaaaagaatcctggccTtggatttagtatcagtggtg	13	12	11	5	0	1	2	1	0	0	2	2	3	2	3	2	3	0	1	2	3	7	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:70555441T>C	uc001dep.2	+	23	4400	c.4370T>C	c.(4369-4371)CTT>CCT	p.L1457P	LRRC7_uc009wbg.2_Missense_Mutation_p.L741P|LRRC7_uc001deq.2_Missense_Mutation_p.L651P	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1457	PDZ.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AATCCTGGCCTTGGATTTAGT	0.289													22	114					0	0	0	0	C	70555441	C	C	70555441	3	2	55	1	0	0	0	0	1	0	0	0	9070	1609	56	5	4460	5	LRRC7	1	70555441	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	13018137	70555441	178695180	8	10741											
ZRANB2	9406	broad.mit.edu	37	chr1	71542527	71542527	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtattacacatattacaCtctgatcttctggcccaatt	11	14	6	10	0	3	1	0	1	3	0	3	2	3	2	1	2	2	1	1	2	5	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:71542527C>A	uc001dft.2	-	4	319	c.252G>T	c.(250-252)GAG>GAT	p.E84D	ZRANB2_uc001dfs.2_Missense_Mutation_p.E84D	NM_203350	NP_976225	O95218	ZRAB2_HUMAN	zinc finger protein 265 isoform 1	84	RanBP2-type 2.				mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						ACATATTACACTCTGATCTTC	0.264													10	99					6.40141e-05	6.7877e-05	1	0	A	71542527	A	A	71542527	3	1	55	1	0	0	0	0	1	0	0	0	18290	564	20	4	806	4	ZRANB2	1	71542527	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	987086	71542527	177708094	9	10742											
C1orf173	127254	broad.mit.edu	37	chr1	75055489	75055489	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctccgttccttctttaagaaCattctcaaagctttcgtcta	9	16	4	12	2	3	1	1	0	3	1	7	1	5	1	2	0	2	2	2	0	4	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:75055489C>A	uc001dgg.2	-	12	2221	c.2002G>T	c.(2002-2004)GTT>TTT	p.V668F	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.V462F	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	668	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCTTTAAGAACATTCTCAAAG	0.398													22	149					3.01185e-09	3.33745e-09	1	0	A	75055489	A	A	75055489	3	1	55	1	0	0	0	0	1	0	0	0	2023	478	17	4	2602	4	C1orf173	1	75055489	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3512962	75055489	174195132	10	10743											
ST6GALNAC3	256435	broad.mit.edu	37	chr1	77094330	77094330	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagggtatagaaaagtccccTaccattattatgaacaagga	17	9	8	7	0	0	2	0	1	0	1	1	3	1	3	3	2	2	1	3	2	10	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:77094330T>C	uc001dhh.2	+	5	920	c.757T>C	c.(757-759)TAC>CAC	p.Y253H	ST6GALNAC3_uc010orh.1_Missense_Mutation_p.Y152H	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	253	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						AAAAGTCCCCTACCATTATTA	0.313													17	77					0	0	0	0	C	77094330	C	C	77094330	3	2	55	1	0	0	0	0	1	0	0	0	15291	1522	53	5	789	5	ST6GALNAC3	1	77094330	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	2038841	77094330	172156291	11	10744											
COL24A1	255631	broad.mit.edu	37	chr1	86426969	86426969	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caatatttccttgatctcctActtctccctgtcaaaaaaga	12	14	3	12	0	3	2	1	1	2	1	6	2	4	2	3	0	1	0	3	0	6	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:86426969A>G	uc001dlj.2	-	24	2567	c.2525T>C	c.(2524-2526)GTA>GCA	p.V842A	COL24A1_uc001dli.2_5'UTR|COL24A1_uc010osd.1_Missense_Mutation_p.V142A|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	842	Collagen-like 5.			GYAGEPGPEGLKGEVGDQGNIG -> ITVFATLYSFLTGRS RRSRKYW (in Ref. 5; BAD92923).	cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTGATCTCCTACTTCTCCCTG	0.269													26	84					0	0	0	0	G	86426969	G	G	86426969	3	3	55	1	0	0	0	0	1	0	0	0	3698	391	14	5	2767	5	COL24A1	1	86426969	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	9332639	86426969	162823652	12	10745											
BARHL2	343472	broad.mit.edu	37	chr1	91182748	91182748	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccgctggccccttccattGtcattgctacatgaggtcca	7	11	8	15	1	1	1	1	1	0	0	3	1	3	1	5	2	2	2	5	2	1	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:91182748G>T	uc001dns.2	-	1	47	c.5C>A	c.(4-6)ACA>AAA	p.T2K		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	2						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		CCCTTCCATTGTCATTGCTAC	0.527													17	136					1.45105e-14	1.69577e-14	1	0	T	91182748	T	T	91182748	3	4	55	1	0	0	0	0	1	0	0	0	1316	1377	48	4	1170	4	BARHL2	1	91182748	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4755779	91182748	158067873	13	10746											
HFM1	164045	broad.mit.edu	37	chr1	91781966	91781966	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaattcaagttcccttgcAtctgtctcttctattttttt	7	20	3	11	0	4	0	1	0	3	0	6	0	5	0	2	0	1	2	2	0	3	8			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:91781966A>T	uc001doa.3	-	26	2980	c.2880T>A	c.(2878-2880)GAT>GAA	p.D960E	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.D639E|HFM1_uc001dob.3_Missense_Mutation_p.D148E|HFM1_uc010osv.1_Missense_Mutation_p.D644E	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	960	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GTTCCCTTGCATCTGTCTCTT	0.299													48	122					0	0	0	0	T	91781966	T	T	91781966	3	4	55	1	0	0	0	0	1	0	0	0	7122	214	8	5	1483	5	HFM1	1	91781966	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	599218	91781966	157468655	14	10747											
SLC44A3	126969	broad.mit.edu	37	chr1	95322999	95322999	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctggactagtgaattcaTccttgcgtgccagcaaatga	11	11	9	10	1	2	2	1	2	1	0	3	3	3	3	2	1	3	1	2	1	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:95322999T>A	uc001dqv.3	+	10	1288	c.1181T>A	c.(1180-1182)ATC>AAC	p.I394N	SLC44A3_uc001dqx.3_Missense_Mutation_p.I394N|SLC44A3_uc010otq.1_Missense_Mutation_p.I326N|SLC44A3_uc010otr.1_Missense_Mutation_p.I358N|SLC44A3_uc001dqw.3_Missense_Mutation_p.I346N|SLC44A3_uc010ots.1_Missense_Mutation_p.I314N|SLC44A3_uc009wds.2_Missense_Mutation_p.I297N|SLC44A3_uc010ott.1_Missense_Mutation_p.I314N|SLC44A3_uc010otu.1_RNA	NM_001114106	NP_001107578	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3 isoform 1	394	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)	1		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	AGTGAATTCATCCTTGCGTGC	0.448													64	166					0	0	0	0	A	95322999	A	A	95322999	3	1	55	1	0	0	0	0	1	0	0	0	14701	1435	50	5	1219	5	SLC44A3	1	95322999	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	3541033	95322999	153927622	15	10748											
SLC44A3	126969	broad.mit.edu	37	chr1	95332973	95332973	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacctgctccatctcaaccaGgtacgtctctacctcttgcc	7	12	5	17	1	3	0	1	0	3	0	6	0	4	0	5	1	6	2	5	1	4	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:95332973G>C	uc001dqv.3	+	12	1589	c.1482G>C	c.(1480-1482)CAG>CAC	p.Q494H	SLC44A3_uc001dqx.3_Missense_Mutation_p.Q493H|SLC44A3_uc010otq.1_Missense_Mutation_p.Q426H|SLC44A3_uc010otr.1_Missense_Mutation_p.Q458H|SLC44A3_uc001dqw.3_Missense_Mutation_p.Q446H|SLC44A3_uc010ots.1_Missense_Mutation_p.Q414H|SLC44A3_uc009wds.2_Missense_Mutation_p.Q397H|SLC44A3_uc010ott.1_Missense_Mutation_p.Q413H|SLC44A3_uc010otu.1_RNA	NM_001114106	NP_001107578	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3 isoform 1	494						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)	1		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	ATCTCAACCAGGTACGTCTCT	0.423													25	165					0	0	0	0	C	95332973	C	C	95332973	3	2	55	1	0	0	0	0	1	0	0	0	14701	1014	35	4	1528	4	SLC44A3	1	95332973	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	9974	95332973	153917648	16	10749											
AMY2B	280	broad.mit.edu	37	chr1	104114736	104114736	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgtttaatttgtaggtctCtccaccaaatgaaaatgttg	12	15	7	7	0	1	1	0	1	1	0	3	1	2	1	2	1	0	3	2	1	5	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:104114736C>G	uc001duq.2	+	4	789	c.173C>G	c.(172-174)TCT>TGT	p.S58C	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.S58C	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	58					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TTGTAGGTCTCTCCACCAAAT	0.313													50	282					0	0	0	0	G	104114736	G	G	104114736	3	3	55	1	0	0	0	0	1	0	0	0	595	913	32	2	179	2	AMY2B	1	104114736	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	8781763	104114736	145135885	17	10750											
AMY2B	280	broad.mit.edu	37	chr1	104115822	104115822	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatattctggatgggatttTaatgatggtaaatgtaaaac	14	14	9	4	0	1	1	0	1	1	0	1	3	1	3	1	3	1	2	1	3	6	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:104115822T>C	uc001duq.2	+	5	1069	c.453T>C	c.(451-453)TTT>TTC	p.F151F	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Silent_p.F151F|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	151					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GATGGGATTTTAATGATGGTA	0.408													71	797					0	0	0	0	C	104115822	C	C	104115822	2	2	55	1	0	0	0	0	0	0	0	1	595	1751	61	5		5	AMY2B	1	104115822	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	1086	104115822	145134799	18	10751											
PRMT6	55170	broad.mit.edu	37	chr1	107600360	107600360	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggacgtttcaggagagatCacgctgctgccctcccggga	8	7	13	13	4	2	1	2	0	0	1	3	5	3	4	2	3	2	3	2	3	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:107600360C>G	uc010ous.1	+	1	1094	c.1023C>G	c.(1021-1023)ATC>ATG	p.I341M		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	341					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity				0		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		CAGGAGAGATCACGCTGCTGC	0.617													9	45					0	0	0	0	G	107600360	G	G	107600360	3	3	55	1	0	0	0	0	1	0	0	0	12602	816	29	2	1025	2	PRMT6	1	107600360	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3484538	107600360	141650261	19	10752											
NES	10763	broad.mit.edu	37	chr1	156641773	156641773	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttgtgattctctgtttctAgaggtctcacaatactctgg	8	17	8	8	0	4	2	1	1	4	1	6	2	4	2	0	2	1	1	0	2	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:156641773A>G	uc001fpq.2	-	4	2340	c.2207T>C	c.(2206-2208)CTA>CCA	p.L736P		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	736	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCTGTTTCTAGAGGTCTCAC	0.428													66	202					0	0	0	0	G	156641773	G	G	156641773	3	3	55	1	0	0	0	0	1	0	0	0	10391	420	15	5	2662	5	NES	1	156641773	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	49041413	156641773	92608848	20	10753											
CD1A	909	broad.mit.edu	37	chr1	158224885	158224885	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgtcgcagggctcaaggagCctctctccttccatgtcacc	6	11	9	15	1	3	0	2	0	1	0	7	1	5	1	4	2	1	2	4	2	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:158224885C>A	uc001frt.2	+	2	603	c.70C>A	c.(70-72)CCT>ACT	p.P24T		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	24	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GCTCAAGGAGCCTCTCTCCTT	0.483													4	188					0.000602214	0.000629065	1	0	A	158224885	A	A	158224885	3	1	55	1	0	0	0	0	1	0	0	0	2989	739	26	4	76	4	CD1A	1	158224885	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	1583112	158224885	91025736	21	10754											
OR10K2	391107	broad.mit.edu	37	chr1	158389862	158389862	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcatcctggcttgaggagtaGttggactgaggccttaagta	9	11	14	7	0	0	2	0	2	0	0	1	4	1	4	2	4	0	5	2	4	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:158389862G>C	uc010pii.1	-	1	795	c.795C>G	c.(793-795)AAC>AAG	p.N265K		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TTGAGGAGTAGTTGGACTGAG	0.398													41	96					0	0	0	0	C	158389862	C	C	158389862	3	2	55	1	0	0	0	0	1	0	0	0	10968	1020	36	4	145	4	OR10K2	1	158389862	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	164977	158389862	90860759	22	10755											
SPTA1	6708	broad.mit.edu	37	chr1	158585170	158585170	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttggttagttgacgcttcatCgcctggatctccttctgttt	4	18	9	10	2	3	1	1	1	2	0	5	2	3	2	2	2	0	4	2	2	1	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:158585170C>T	uc001fst.1	-	48	6823	c.6624G>A	c.(6622-6624)GCG>GCA	p.A2208A		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2208	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GACGCTTCATCGCCTGGATCT	0.468													92	198					0	0	0	0	T	158585170	T	T	158585170	2	4	55	1	0	0	0	0	0	0	0	1	15182	871	31	1		1	SPTA1	1	158585170	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	195308	158585170	90665451	23	10756											
OR6K2	81448	broad.mit.edu	37	chr1	158669837	158669837	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataatctccactgcatgaatGacatccactacctgaatcat	14	11	4	12	0	2	3	1	3	1	0	4	3	3	3	3	0	2	1	3	0	4	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:158669837G>C	uc001fsu.1	-	1	606	c.606C>G	c.(604-606)GTC>GTG	p.V202V		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					CTGCATGAATGACATCCACTA	0.483													33	115					0	0	0	0	C	158669837	C	C	158669837	2	2	55	1	0	0	0	0	0	0	0	1	11256	1277	45	2		2	OR6K2	1	158669837	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	84667	158669837	90580784	24	10757											
IGSF9	57549	broad.mit.edu	37	chr1	159897613	159897613	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcccaggtgcaaagtctccaGcaattccatgtccccaggga	10	7	10	14	0	1	0	0	0	1	0	4	1	3	1	5	2	2	2	5	2	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:159897613G>A	uc001fur.2	-	20	3493	c.3295C>T	c.(3295-3297)CTG>TTG	p.L1099L	IGSF9_uc001fuq.2_Silent_p.L1083L|CCDC19_uc001ful.2_5'Flank|TAGLN2_uc001fun.1_5'Flank|TAGLN2_uc001fuo.1_5'Flank|TAGLN2_uc010piy.1_5'Flank|IGSF9_uc001fup.2_Silent_p.L245L	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	1099	Cytoplasmic (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			AAAGTCTCCAGCAATTCCATG	0.527													32	103					0	0	0	0	A	159897613	A	A	159897613	2	1	55	1	0	0	0	0	0	0	0	1	7644	962	34	4		4	IGSF9	1	159897613	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1227776	159897613	89353008	25	10758											
RXRG	6258	broad.mit.edu	37	chr1	165380003	165380004	+	Missense_Mutation	DNP	CC	AT	AT																															aagtggggaatacgcttggcCcattcaacgagggtgaaaag																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:165380003_165380004CC>AT	uc001gda.2	-	6	1148_1149	c.848_849GG>AT	c.(847-849)TGG>TAT	p.W283Y		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	283	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	TACGCTTGGCCCATTCAACGAG	0.49													7	47					0	0	0	0	AT	165380004	AT	AT	165380003	3	1	55	1	0	0	0	0	1	0	0	0	13830	624	22	4	562	4	RXRG	1	165380003	Missense_Mutation	DNP	CC	TCGA-CN-5356-01A-01D-1434-08	5482390	165380003	83870618	26	10759											
SELE	6401	broad.mit.edu	37	chr1	169698381	169698381	+	Frame_Shift_Del	DEL	G	-	-																															ttgagtggtgcattcaacctGggctggtccctgcaacatga																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:169698381delG	uc001ggm.3	-	7	1193	c.1036delC	c.(1036-1038)CAGfs	p.Q346fs	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	346	Extracellular (Potential).|Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					CATTCAACCTGGGCTGGTCCC	0.488													---	---	---								-	169698381	-	-	169698381	7	5	55	1	0	1	0	1	0	0	0	0	14078	1357	47	0	824	0	SELE	1	169698381	Frame_Shift_Del	DEL	G	TCGA-CN-5356-01A-01D-1434-08	4318378	169698381	79552240	27	10760											
BAT2L2	23215	broad.mit.edu	37	chr1	171452363	171452363	+	5'Flank	DEL	A	-	-																															cagagtgagactccatggggAaaaaaaaaaagaaagaagga																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:171452363delA	uc010pmg.1	+						BAT2L2_uc001ghq.1_5'Flank|BAT2L2_uc001ghr.1_5'Flank	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2								protein C-terminus binding				0						ctccatggggaaaaaaaaaaa	0													---	---	---								-	171452363	-	-	171452363	6	5	55	0	1	1	0	1	0	0	0	0	1323	261	9	0		0	BAT2L2	1	171452363	5'Flank	DEL	A	TCGA-CN-5356-01A-01D-1434-08	1753982	171452363	77798258	28	10761											
QSOX1	5768	broad.mit.edu	37	chr1	180165686	180165686	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggaagcctgagatgatGaagtcccccacaaacaccac	13	5	9	14	0	0	3	0	3	0	1	1	5	1	4	5	1	2	0	5	1	3	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:180165686G>T	uc001gnz.2	+	12	1833	c.1758G>T	c.(1756-1758)ATG>ATT	p.M586I	QSOX1_uc001gny.2_Missense_Mutation_p.M586I|QSOX1_uc001goa.2_Missense_Mutation_p.M586I|QSOX1_uc001goc.2_Missense_Mutation_p.M128I|FLJ23867_uc001god.3_5'Flank	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	586					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						CTGAGATGATGAAGTCCCCCA	0.637													45	132					2.20914e-33	2.85275e-33	1	0	T	180165686	T	T	180165686	3	4	55	1	0	0	0	0	1	0	0	0	12948	1290	45	2	1804	2	QSOX1	1	180165686	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	8713323	180165686	69084935	29	10762											
LAMC1	3915	broad.mit.edu	37	chr1	183105651	183105651	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcaggccctgggcagtgcTgcggcggatgccacagaggc	7	4	17	13	2	0	1	0	0	0	1	0	2	0	2	2	5	4	3	2	5	0	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:183105651T>G	uc001gpy.3	+	25	4502	c.4245T>G	c.(4243-4245)GCT>GCG	p.A1415A		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	1415	Potential.|Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGGCAGTGCTGCGGCGGATG	0.592													4	53					0	0	0	0	G	183105651	G	G	183105651	2	3	55	1	0	0	0	0	0	0	0	1	8654	1567	55	5		5	LAMC1	1	183105651	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	2939965	183105651	66144970	30	10763											
SMG7	9887	broad.mit.edu	37	chr1	183515266	183515267	+	Frame_Shift_Ins	INS	-	A	A																															aatgcagcagcagcctctagINSaaaaaaaaatgaagcctttt																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:183515266_183515267insA	uc001gqg.2	+	17	2658_2659	c.2536_2537insA	c.(2536-2538)GAAfs	p.E846fs	SMG7_uc010pob.1_Frame_Shift_Ins_p.E829fs|SMG7_uc001gqf.2_Frame_Shift_Ins_p.E800fs|SMG7_uc001gqh.2_Frame_Shift_Ins_p.E800fs|SMG7_uc001gqi.2_Frame_Shift_Ins_p.E758fs|SMG7_uc010poc.1_Frame_Shift_Ins_p.E804fs	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	846					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GCAGCCTCTAGAAAAAAAAATG	0.45													---	---	---								A	183515267	A	A	183515266	7	5	55	1	0	1	1	0	0	0	0	0	14862	943	33	0	2602	0	SMG7	1	183515266	Frame_Shift_Ins	INS	-	TCGA-CN-5356-01A-01D-1434-08	409615	183515266	65735355	31	10764											
ZBTB41	360023	broad.mit.edu	37	chr1	197128771	197128771	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcactcggagtgtcaggcatCtgaactggaaccagagttac	11	9	11	10	1	3	2	2	1	1	1	4	4	3	4	1	3	3	2	1	3	3	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:197128771C>T	uc001gtx.1	-	10	2517	c.2448G>A	c.(2446-2448)CAG>CAA	p.Q816Q	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	816					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TGTCAGGCATCTGAACTGGAA	0.463													52	120					0	0	0	0	T	197128771	T	T	197128771	2	4	55	1	0	0	0	0	0	0	0	1	17610	912	32	2		2	ZBTB41	1	197128771	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	13613505	197128771	52121850	32	10765											
CRB1	23418	broad.mit.edu	37	chr1	197390919	197390919	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aattgattggaatcacattaCcctggagaacatctcgtctg	12	12	8	9	1	3	2	1	1	2	1	4	4	3	3	1	2	2	0	1	2	4	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:197390919C>T	uc001gtz.2	+	6	2096	c.1961C>T	c.(1960-1962)ACC>ATC	p.T654I	CRB1_uc010poz.1_Missense_Mutation_p.T585I|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.T542I|CRB1_uc010ppb.1_Missense_Mutation_p.T654I|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.T135I|CRB1_uc001gub.1_Missense_Mutation_p.T303I	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	654	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding	p.T654T(1)		ovary(5)|skin(3)|large_intestine(1)	9						AATCACATTACCCTGGAGAAC	0.448													68	218					0	0	0	0	T	197390919	T	T	197390919	3	4	55	1	0	0	0	0	1	0	0	0	3863	507	18	4	1983	4	CRB1	1	197390919	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	262148	197390919	51859702	33	10766											
CRB1	23418	broad.mit.edu	37	chr1	197404293	197404293	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caagggtgtctaagtacaatAgaaatcggaggcatttatct	14	11	10	6	1	2	1	0	0	2	1	3	2	2	2	0	3	1	2	0	3	7	5	rs146270698	by1000genomes	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:197404293A>G	uc001gtz.2	+	9	3435	c.3300A>G	c.(3298-3300)ATA>ATG	p.I1100M	CRB1_uc010poz.1_Missense_Mutation_p.I1076M|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.I988M|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.I581M|CRB1_uc001gub.1_Missense_Mutation_p.I749M	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1100	Extracellular (Potential).|Laminin G-like 3.		I -> R (in LCA8).|I -> T (in RP12).		cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TAAGTACAATAGAAATCGGAG	0.368													47	119					0	0	0	0	G	197404293	G	G	197404293	3	3	55	1	0	0	0	0	1	0	0	0	3863	410	15	5	3334	5	CRB1	1	197404293	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	13374	197404293	51846328	34	10767											
IPO9	55705	broad.mit.edu	37	chr1	201839980	201839980	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggcagagacgctcagtgtCatgcaggtaagagagcagtg	12	6	15	8	1	2	2	2	0	0	2	2	4	2	2	0	2	2	5	0	2	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:201839980C>T	uc001gwz.2	+	18	2453	c.2403C>T	c.(2401-2403)GTC>GTT	p.V801V		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	801					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						CGCTCAGTGTCATGCAGGTAA	0.498													12	70					0	0	0	0	T	201839980	T	T	201839980	2	4	55	1	0	0	0	0	0	0	0	1	7838	813	29	2		2	IPO9	1	201839980	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	4435687	201839980	47410641	35	10768											
IKBKE	9641	broad.mit.edu	37	chr1	206648211	206648211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctgtcccacccatagggcGgaagccggcagaaggtactg	9	6	13	13	2	1	1	0	0	1	1	2	2	2	2	3	4	2	2	3	4	4	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:206648211G>A	uc001hdz.1	+	5	600	c.232G>A	c.(232-234)GGA>AGA	p.G78R	IKBKE_uc009xbu.1_Missense_Mutation_p.G78R|IKBKE_uc009xbv.1_Missense_Mutation_p.G78R|IKBKE_uc001hea.1_5'UTR	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	78	Protein kinase.				DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					CCCATAGGGCGGAAGCCGGCA	0.617													7	50					0	0	0	0	A	206648211	A	A	206648211	3	1	55	1	0	0	0	0	1	0	0	0	7651	1117	39	1	242	1	IKBKE	1	206648211	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4808231	206648211	42602410	36	10769											
DYRK3	8444	broad.mit.edu	37	chr1	206821624	206821624	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgactttgggtccagctgtTtcgagtaccagaagctctac	8	13	10	10	1	1	2	0	1	1	1	3	3	2	2	2	1	4	4	2	1	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:206821624T>G	uc001hej.2	+	3	1249	c.1081T>G	c.(1081-1083)TTC>GTC	p.F361V	DYRK3_uc001hek.2_Intron|DYRK3_uc001hei.2_Missense_Mutation_p.F341V	NM_003582	NP_003573	O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	361	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|central_nervous_system(1)	3	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			GTCCAGCTGTTTCGAGTACCA	0.453													12	188					0	0	0	0	G	206821624	G	G	206821624	3	3	55	1	0	0	0	0	1	0	0	0	4879	1841	64	5	1112	5	DYRK3	1	206821624	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	173413	206821624	42428997	37	10770											
FCAMR	83953	broad.mit.edu	37	chr1	207135666	207135666	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttgggacagcctcaccaCaaacaagcctctctgtggaa	12	7	9	13	0	2	0	1	0	1	0	3	2	2	2	3	2	3	1	3	2	3	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:207135666C>A	uc001hfa.3	-	5	1044	c.544G>T	c.(544-546)GTG>TTG	p.V182L	FCAMR_uc001hfb.2_Missense_Mutation_p.V182L|FCAMR_uc009xca.1_Missense_Mutation_p.V182L|FCAMR_uc001hfc.2_Missense_Mutation_p.V157L	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	137	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						AGCCTCACCACAAACAAGCCT	0.507													3	50					2.32078e-09	2.59506e-09	1	0	A	207135666	A	A	207135666	3	1	55	1	0	0	0	0	1	0	0	0	5804	478	17	4	1205	4	FCAMR	1	207135666	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	314042	207135666	42114955	38	10771											
INTS7	25896	broad.mit.edu	37	chr1	212118271	212118271	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctggttattctggacagcaAtgggctctgcaggattccgg	7	11	14	9	1	2	0	0	0	2	0	3	2	3	2	1	5	2	5	1	5	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:212118271A>G	uc001hiw.1	-	19	2561	c.2456T>C	c.(2455-2457)ATT>ACT	p.I819T	INTS7_uc009xdb.1_Missense_Mutation_p.I799T|INTS7_uc001hix.1_Missense_Mutation_p.I695T|INTS7_uc001hiy.1_Missense_Mutation_p.I805T|INTS7_uc010pta.1_Missense_Mutation_p.I770T	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	819					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CTGGACAGCAATGGGCTCTGC	0.512													23	72					0	0	0	0	G	212118271	G	G	212118271	3	3	55	1	0	0	0	0	1	0	0	0	7822	101	4	5	440	5	INTS7	1	212118271	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	4982605	212118271	37132350	39	10772											
USH2A	7399	broad.mit.edu	37	chr1	216074210	216074210	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctgaagactggttggagtGgcagatgaaagcctgggagg	11	7	17	6	0	0	4	0	2	0	2	0	6	0	6	2	5	1	2	2	5	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:216074210G>A	uc001hku.1	-	39	7725	c.7338C>T	c.(7336-7338)GCC>GCT	p.A2446A		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2446	Extracellular (Potential).|Fibronectin type-III 11.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTTGGAGTGGCAGATGAAA	0.517										HNSCC(13;0.011)			26	91					0	0	0	0	A	216074210	A	A	216074210	2	1	55	1	0	0	0	0	0	0	0	1	17104	1335	47	4		4	USH2A	1	216074210	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	3955939	216074210	33176411	40	10773											
KIAA1383	54627	broad.mit.edu	37	chr1	232941433	232941433	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggccccggcgctcccgccGccgaaccgtggcccggtgtc	3	4	14	20	8	0	0	0	0	0	0	2	1	1	0	7	4	1	1	7	4	1	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:232941433G>C	uc001hvh.2	+	1	796	c.664G>C	c.(664-666)GCC>CCC	p.A222P		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	80										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				CGCTCCCGCCGCCGAACCGTG	0.721													4	20					0	0	0	0	C	232941433	C	C	232941433	3	2	55	1	0	0	0	0	1	0	0	0	8267	1087	38	3	666	3	KIAA1383	1	232941433	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	16867223	232941433	16309188	41	10774											
RYR2	6262	broad.mit.edu	37	chr1	237666648	237666648	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttcttcctccacctgggtAtgctccttgttatgaagctg	6	16	8	11	0	1	1	0	1	1	0	4	1	4	1	4	1	2	4	4	1	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:237666648A>G	uc001hyl.1	+	22	2576	c.2456A>G	c.(2455-2457)TAT>TGT	p.Y819C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	819	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCACCTGGGTATGCTCCTTGT	0.458													8	34					0	0	0	0	G	237666648	G	G	237666648	3	3	55	1	0	0	0	0	1	0	0	0	13834	449	16	5	2542	5	RYR2	1	237666648	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	4725215	237666648	11583973	42	10775											
RYR2	6262	broad.mit.edu	37	chr1	237935319	237935319	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttatcttgcatagattttcaGaattatctgagaactcagac	13	15	6	7	0	4	4	2	1	2	4	4	5	4	4	0	0	2	1	0	0	5	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:237935319G>A	uc001hyl.1	+	86	11685	c.11565G>A	c.(11563-11565)CAG>CAA	p.Q3855Q	RYR2_uc010pya.1_Silent_p.Q270Q	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3855					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TAGATTTTCAGAATTATCTGA	0.343													5	7					0	0	0	0	A	237935319	A	A	237935319	2	1	55	1	0	0	0	0	0	0	0	1	13834	933	33	2		2	RYR2	1	237935319	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	268671	237935319	11315302	43	10776											
OR14A16	284532	broad.mit.edu	37	chr1	247978121	247978121	+	Frame_Shift_Del	DEL	C	-	-																															tttactttttggtgagctttCcctttatcaacatccccaga																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr1:247978121delC	uc001idm.1	-	1	911	c.911delG	c.(910-912)GGAfs	p.G304fs		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGTGAGCTTTCCCTTTATCAA	0.343													---	---	---								-	247978121	-	-	247978121	7	5	55	1	0	1	0	1	0	0	0	0	10999	855	30	0	22	0	OR14A16	1	247978121	Frame_Shift_Del	DEL	C	TCGA-CN-5356-01A-01D-1434-08	10042802	247978121	1272500	44	10777											
SOX11	6664	broad.mit.edu	37	chr2	5832931	5832931	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacacggaggagggcgaattCatggcttgcagcccggtggc	8	6	17	10	3	1	0	1	0	0	0	1	4	1	2	1	6	2	2	1	6	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:5832931C>T	uc002qyj.2	+	1	133	c.78C>T	c.(76-78)TTC>TTT	p.F26F		NM_003108	NP_003099	P35716	SOX11_HUMAN	SRY-box 11	26					cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(3)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		AGGGCGAATTCATGGCTTGCA	0.657													5	18					0	0	0	0	T	5832931	T	T	5832931	2	4	55	1	0	0	0	0	0	0	0	1	15006	825	29	2		2	SOX11	2	5832931	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08		5832931	237366442	45	10778											
NBAS	51594	broad.mit.edu	37	chr2	15567910	15567910	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaatgatcatcagggagtcaCcgttaaaactcaaatttaaa	17	10	7	7	1	4	1	4	1	0	0	4	3	4	2	1	1	1	1	1	1	6	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:15567910C>A	uc002rcc.1	-	22	2374	c.2348G>T	c.(2347-2349)GGT>GTT	p.G783V	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	783										ovary(2)|liver(1)|skin(1)	4						CAGGGAGTCACCGTTAAAACT	0.398													6	27					0.00116845	0.00120772	1	0	A	15567910	A	A	15567910	3	1	55	1	0	0	0	0	1	0	0	0	10239	507	18	4	4891	4	NBAS	2	15567910	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	9734979	15567910	227631463	46	10779											
AGBL5	60509	broad.mit.edu	37	chr2	27281352	27281352	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgtcagagcacagcagcCttactaatctacgggcctgg	10	9	10	12	1	2	1	1	0	1	1	2	1	2	1	2	2	6	2	2	2	4	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:27281352C>T	uc002rie.2	+	10	1973	c.1756C>T	c.(1756-1758)CTT>TTT	p.L586F	AGBL5_uc002rid.2_Missense_Mutation_p.L586F|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	586					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCACAGCAGCCTTACTAATCT	0.557													47	115					0	0	0	0	T	27281352	T	T	27281352	3	4	55	1	0	0	0	0	1	0	0	0	378	681	24	4	1790	4	AGBL5	2	27281352	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	11713442	27281352	215918021	47	10780											
BIRC6	57448	broad.mit.edu	37	chr2	32770763	32770763	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccaacccttcctttccacGtccttcgtagcttgtttagc	5	16	5	15	2	0	0	0	0	0	0	5	0	4	0	5	0	3	3	5	0	3	8			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:32770763G>T	uc010ezu.2	+	63	12780	c.12646G>T	c.(12646-12648)GTC>TTC	p.V4216F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4216					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TCCTTTCCACGTCCTTCGTAG	0.413													92	286					1.11883e-47	1.48774e-47	1	0	T	32770763	T	T	32770763	3	4	55	1	0	0	0	0	1	0	0	0	1441	1145	40	3	12896	3	BIRC6	2	32770763	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	5489411	32770763	210428610	48	10781											
SIX2	10736	broad.mit.edu	37	chr2	45233600	45233600	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcagcgggttgtggctgttAgaattggagttctcgttgtt	5	17	14	5	2	2	1	1	0	1	1	3	2	2	2	0	3	1	6	0	3	2	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:45233600A>G	uc002ruo.2	-	2	878	c.585T>C	c.(583-585)TCT>TCC	p.S195S	SIX2_uc002rup.2_Silent_p.S197S	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	195						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGTGGCTGTTAGAATTGGAGT	0.587													21	185					0	0	0	0	G	45233600	G	G	45233600	2	3	55	1	0	0	0	0	0	0	0	1	14412	407	15	5		5	SIX2	2	45233600	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	12462837	45233600	197965773	49	10782											
ALMS1	7840	broad.mit.edu	37	chr2	73747023	73747023	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttcatctgagatttttattAatgctgaagatcgtggacat	11	17	8	5	1	2	3	1	2	1	2	3	5	2	4	0	1	1	1	0	1	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:73747023A>G	uc002sje.1	+	13	9775	c.9664A>G	c.(9664-9666)AAT>GAT	p.N3222D	ALMS1_uc002sjf.1_Missense_Mutation_p.N3178D|ALMS1_uc002sjg.2_Missense_Mutation_p.N2608D|ALMS1_uc002sjh.1_Missense_Mutation_p.N2608D|ALMS1_uc010fev.1_Missense_Mutation_p.N37D	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3220					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GATTTTTATTAATGCTGAAGA	0.403													28	179					0	0	0	0	G	73747023	G	G	73747023	3	3	55	1	0	0	0	0	1	0	0	0	535	362	13	5	9700	5	ALMS1	2	73747023	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	28513423	73747023	169452350	50	10783											
NAT8B	51471	broad.mit.edu	37	chr2	73927774	73927774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacgccctgcctgagcagaaGggaggtgatagatgaaatga	13	6	15	7	1	0	6	0	4	0	2	0	8	0	7	2	2	2	1	2	2	3	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:73927774G>A	uc002sjk.1	-	3	694	c.659C>T	c.(658-660)CCT>CTT	p.P220L		NM_016347	NP_057431	Q9UHF3	NAT8B_HUMAN	N-acetyltransferase 8B	220					gastrulation with mouth forming second	integral to membrane	N-acetyltransferase activity				0						CTGAGCAGAAGGGAGGTGATA	0.358													12	35					0	0	0	0	A	73927774	A	A	73927774	3	1	55	1	0	0	0	0	1	0	0	0	10233	1000	35	4	28	4	NAT8B	2	73927774	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	180751	73927774	169271599	51	10784											
THNSL2	55258	broad.mit.edu	37	chr2	88482287	88482287	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaaccgcaatgacatcaTccacaggactgtccagcagg	13	6	10	12	1	1	2	1	2	0	0	3	3	3	3	3	2	2	2	3	2	2	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:88482287T>A	uc002ssz.3	+	6	1025	c.872T>A	c.(871-873)ATC>AAC	p.I291N	THNSL2_uc002ssv.2_RNA|THNSL2_uc002ssw.3_Missense_Mutation_p.I291N|THNSL2_uc002ssx.3_Intron|THNSL2_uc002sta.3_Missense_Mutation_p.I133N|THNSL2_uc002ssy.3_Missense_Mutation_p.I291N|THNSL2_uc010fhe.2_Missense_Mutation_p.I133N	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	291					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						AATGACATCATCCACAGGACT	0.507													31	98					0	0	0	0	A	88482287	A	A	88482287	3	1	55	1	0	0	0	0	1	0	0	0	15929	1435	50	5	890	5	THNSL2	2	88482287	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	14554513	88482287	154717086	52	10785											
LYG1	129530	broad.mit.edu	37	chr2	99909015	99909015	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaccacagtagttcaggccGtgacgtcttccaatcccaca	10	9	7	15	2	2	1	1	1	1	0	4	1	4	1	4	1	1	2	4	1	3	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:99909015G>T	uc002szy.2	-	4	382	c.132C>A	c.(130-132)CAC>CAA	p.H44Q	MRPL30_uc002szl.1_Intron|LYG1_uc010yvo.1_Missense_Mutation_p.H44Q	NM_174898	NP_777558	Q8N1E2	LYG1_HUMAN	lysozyme g-like protein 1 precursor	44					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity				0						AGTTCAGGCCGTGACGTCTTC	0.517													26	115					2.41591e-17	2.91138e-17	1	0	T	99909015	T	T	99909015	3	4	55	1	0	0	0	0	1	0	0	0	9155	1136	40	3	468	3	LYG1	2	99909015	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	11426728	99909015	143290358	53	10786											
MFSD9	84804	broad.mit.edu	37	chr2	103335339	103335339	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgctgtaactgatgaggtagCctgtcaccttgggccgcacc	7	10	12	12	1	1	2	1	2	0	0	1	2	1	2	4	2	3	4	4	2	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:103335339C>T	uc002tcb.2	-	6	1033	c.965G>A	c.(964-966)GGC>GAC	p.G322D	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	322					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						GATGAGGTAGCCTGTCACCTT	0.607													14	73					0	0	0	0	T	103335339	T	T	103335339	3	4	55	1	0	0	0	0	1	0	0	0	9592	739	26	4	463	4	MFSD9	2	103335339	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3426324	103335339	139864034	54	10787											
SH3RF3	344558	broad.mit.edu	37	chr2	110036087	110036088	+	Frame_Shift_Ins	INS	-	T	T																															cgcctcccaaggtccagctgINScccctcaacgtgtgagctgc																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:110036087_110036088insT	uc010ywt.1	+	5	1392_1393	c.1392_1393insT	c.(1390-1395)CTGCCCfs	p.L464fs		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	464_465	SH3 3.						zinc ion binding			ovary(1)	1						AGGTCCAGCTGCCCCTCAACGT	0.663													---	---	---								T	110036088	T	T	110036087	7	5	55	1	0	1	1	0	0	0	0	0	14325	1306	46	0	1410	0	SH3RF3	2	110036087	Frame_Shift_Ins	INS	-	TCGA-CN-5356-01A-01D-1434-08	6700748	110036087	133163286	55	10788											
CYP27C1	339761	broad.mit.edu	37	chr2	127957114	127957114	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgttgtcaacatgaatttgGcctgtttgaaaacagtattt	11	17	8	5	0	1	2	1	2	0	0	1	2	1	2	1	1	2	3	1	1	5	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:127957114G>A	uc002tod.2	-	4	521	c.390C>T	c.(388-390)AGC>AGT	p.S130S		NM_001001665	NP_001001665	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C,	130						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		CATGAATTTGGCCTGTTTGAA	0.463													23	31					0	0	0	0	A	127957114	A	A	127957114	2	1	55	1	0	0	0	0	0	0	0	1	4177	1217	42	4		4	CYP27C1	2	127957114	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	17921027	127957114	115242259	56	10789											
R3HDM1	23518	broad.mit.edu	37	chr2	136374308	136374308	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaccaccccctgcaccagAgatatcacaggagaaccagg	13	4	8	16	0	1	2	1	0	0	2	2	4	2	2	6	2	2	1	6	2	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:136374308A>C	uc002tuo.2	+	5	654	c.284A>C	c.(283-285)GAG>GCG	p.E95A	R3HDM1_uc010fni.2_Missense_Mutation_p.E93A|R3HDM1_uc002tup.2_Intron	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	95							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		CCTGCACCAGAGATATCACAG	0.368													9	26					0	0	0	0	C	136374308	C	C	136374308	3	2	55	1	0	0	0	0	1	0	0	0	12952	304	11	5	294	5	R3HDM1	2	136374308	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	8417194	136374308	106825065	57	10790											
LRP1B	53353	broad.mit.edu	37	chr2	141032117	141032117	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacacattcaacacttccatCatccccaatggtacatgatt	13	11	4	13	0	2	1	2	1	0	0	4	2	4	1	3	1	2	1	3	1	3	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:141032117C>T	uc002tvj.1	-	85	13990	c.13018G>A	c.(13018-13020)GAT>AAT	p.D4340N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4340	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACACTTCCATCATCCCCAATG	0.403										TSP Lung(27;0.18)			58	66					0	0	0	0	T	141032117	T	T	141032117	3	4	55	1	0	0	0	0	1	0	0	0	9005	826	29	2	809	2	LRP1B	2	141032117	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	4657809	141032117	102167256	58	10791											
LRP1B	53353	broad.mit.edu	37	chr2	141108504	141108504	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctgttattcttgaattatgTtcaatatgagaaatttgttg	11	19	7	4	0	2	2	1	2	1	1	2	3	2	2	1	0	0	3	1	0	6	8			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:141108504T>A	uc002tvj.1	-	77	12726	c.11754A>T	c.(11752-11754)GAA>GAT	p.E3918D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3918	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGAATTATGTTCAATATGAG	0.338										TSP Lung(27;0.18)			107	120					0	0	0	0	A	141108504	A	A	141108504	3	1	55	1	0	0	0	0	1	0	0	0	9005	1722	60	5	2105	5	LRP1B	2	141108504	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	76387	141108504	102090869	59	10792											
TANC1	85461	broad.mit.edu	37	chr2	160084427	160084427	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catgagacccttcaatgaatTaagggtttccctctatctca	11	13	6	11	0	3	2	2	2	2	1	5	3	4	2	2	1	0	1	2	1	4	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:160084427T>A	uc002uag.2	+	25	4275	c.4001T>A	c.(4000-4002)TTA>TAA	p.L1334*	TANC1_uc010zcm.1_Nonsense_Mutation_p.L1326*|TANC1_uc010fom.1_Nonsense_Mutation_p.L1140*|TANC1_uc010fon.2_Nonsense_Mutation_p.L178*	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1334						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TTCAATGAATTAAGGGTTTCC	0.458													72	65					0	0	0	0	A	160084427	A	A	160084427	4	1	55	1	0	0	0	0	0	1	0	0	15610	1764	61	5	4091	5	TANC1	2	160084427	Nonsense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	18975923	160084427	83114946	60	10793											
KLHL23	151230	broad.mit.edu	37	chr2	170598005	170598005	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagttcagagctacaattccGatatcaacgaatggagcctc	14	9	8	10	2	2	1	2	0	0	1	4	4	3	2	2	1	4	2	2	1	6	4	rs140221414		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:170598005G>A	uc002ufh.1	+	5	1662	c.1324G>A	c.(1324-1326)GAT>AAT	p.D442N	KLHL23_uc002ufi.1_Missense_Mutation_p.D442N	NM_144711	NP_653312	Q8NBE8	KLH23_HUMAN	kelch-like 23	442	Kelch 4.										0						CTACAATTCCGATATCAACGA	0.433													12	122					0	0	0	0	A	170598005	A	A	170598005	3	1	55	1	0	0	0	0	1	0	0	0	8417	1058	37	1	1330	1	KLHL23	2	170598005	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	10513578	170598005	72601368	61	10794											
TTN	7273	broad.mit.edu	37	chr2	179582426	179582426	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaccccatccttgtaccaaGacacttgaagaggttctgag	12	9	9	11	0	1	4	0	2	1	2	2	5	2	4	4	1	2	2	4	1	4	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:179582426G>T	uc010zfg.1	-	84	21667	c.21443C>A	c.(21442-21444)TCT>TAT	p.S7148Y	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S3809Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8075							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTGTACCAAGACACTTGAAG	0.413													29	41					7.26314e-15	8.50825e-15	1	0	T	179582426	T	T	179582426	3	4	55	1	0	0	0	0	1	0	0	0	16803	942	33	2	79458	2	TTN	2	179582426	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	8984421	179582426	63616947	62	10795											
COL5A2	1290	broad.mit.edu	37	chr2	189927938	189927938	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggcccatgctcccgggcTgccctctgattcctatggag	6	9	12	14	1	1	1	0	1	1	0	3	3	3	2	4	3	2	2	4	3	2	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:189927938T>A	uc002uqk.2	-	27	2104	c.1829A>T	c.(1828-1830)CAG>CTG	p.Q610L	COL5A2_uc010frx.2_Missense_Mutation_p.Q186L	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	610					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GCTCCCGGGCTGCCCTCTGAT	0.527													37	253					0	0	0	0	A	189927938	A	A	189927938	3	1	55	1	0	0	0	0	1	0	0	0	3712	1580	55	5	2782	5	COL5A2	2	189927938	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	10345512	189927938	53271435	63	10796											
DNAH7	56171	broad.mit.edu	37	chr2	196759837	196759837	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagaatcttctcggaaaagaAtgcagtcatttgcaaattca	16	11	7	7	1	4	2	2	0	2	2	5	3	4	3	0	1	2	2	0	1	6	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:196759837A>G	uc002utj.3	-	30	4860	c.4759T>C	c.(4759-4761)TTC>CTC	p.F1587L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1587	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCGGAAAAGAATGCAGTCATT	0.373													45	60					0	0	0	0	G	196759837	G	G	196759837	3	3	55	1	0	0	0	0	1	0	0	0	4628	101	4	5	7459	5	DNAH7	2	196759837	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	6831899	196759837	46439536	64	10797											
MAP2	4133	broad.mit.edu	37	chr2	210558740	210558740	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtctcccatgcataaaaatGgtgacaaggagtttcaaaca	15	10	8	8	0	2	1	1	1	1	0	3	2	2	2	1	2	2	2	1	2	5	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:210558740G>C	uc002vde.1	+	7	2094	c.1846G>C	c.(1846-1848)GGT>CGT	p.G616R	MAP2_uc002vdc.1_Missense_Mutation_p.G616R|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.G612R	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	616					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GCATAAAAATGGTGACAAGGA	0.443													30	65					0	0	0	0	C	210558740	C	C	210558740	3	2	55	1	0	0	0	0	1	0	0	0	9288	1348	47	4	1860	4	MAP2	2	210558740	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	13798903	210558740	32640633	65	10798											
ABCA12	26154	broad.mit.edu	37	chr2	215891574	215891574	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggccaaactgtcagtcaCatttctcacacatgccaagt	11	11	6	13	0	4	0	3	0	2	0	5	0	4	0	2	1	2	0	2	1	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:215891574C>T	uc002vew.2	-	10	1370	c.1150G>A	c.(1150-1152)GTG>ATG	p.V384M	ABCA12_uc002vev.2_Missense_Mutation_p.V66M|ABCA12_uc010zjn.1_Translation_Start_Site	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	384					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTGTCAGTCACATTTCTCACA	0.388													104	217					0	0	0	0	T	215891574	T	T	215891574	3	4	55	1	0	0	0	0	1	0	0	0	30	478	17	4	6813	4	ABCA12	2	215891574	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	5332834	215891574	27307799	66	10799											
EPHA4	2043	broad.mit.edu	37	chr2	222307601	222307602	+	Frame_Shift_Ins	INS	-	A	A																															tcggatggtcaaactgtcccINSatgatgctggcctcactcag																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:222307601_222307602insA	uc002vmq.2	-	11	2063_2064	c.2021_2022insT	c.(2020-2022)ATGfs	p.M674fs	EPHA4_uc002vmr.2_Frame_Shift_Ins_p.M674fs|EPHA4_uc010zlm.1_Frame_Shift_Ins_p.M615fs|EPHA4_uc010zln.1_Frame_Shift_Ins_p.M674fs	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	674	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CAAACTGTCCCATGATGCTGGC	0.48													---	---	---								A	222307602	A	A	222307601	7	5	55	1	0	1	1	0	0	0	0	0	5193	594	21	0	966	0	EPHA4	2	222307601	Frame_Shift_Ins	INS	-	TCGA-CN-5356-01A-01D-1434-08	6416027	222307601	20891772	67	10800											
SCG2	7857	broad.mit.edu	37	chr2	224462778	224462778	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccactcttggagagcatcCtattttggaacaggtctgga	10	11	11	9	0	2	1	0	0	2	1	3	4	3	3	2	4	3	1	2	4	2	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:224462778C>G	uc002vnm.2	-	2	1356	c.1223G>C	c.(1222-1224)AGG>ACG	p.R408T		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	408					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		GGAGAGCATCCTATTTTGGAA	0.512													67	70					0	0	0	0	G	224462778	G	G	224462778	3	3	55	1	0	0	0	0	1	0	0	0	13956	681	24	4	634	4	SCG2	2	224462778	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2155177	224462778	18736595	68	10801											
DOCK10	55619	broad.mit.edu	37	chr2	225651808	225651808	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaattcaccacctctgccacTttcagatatgaccgatgaat	12	11	6	12	1	3	3	2	2	1	1	3	5	3	3	4	0	1	0	4	0	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:225651808T>C	uc010fwz.1	-	50	5825	c.5586A>G	c.(5584-5586)AAA>AAG	p.K1862K	DOCK10_uc002vob.2_Silent_p.K1856K|DOCK10_uc002voa.2_Silent_p.K518K|DOCK10_uc002voc.2_Silent_p.K683K	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1862	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CCTCTGCCACTTTCAGATATG	0.428													82	87					0	0	0	0	C	225651808	C	C	225651808	2	2	55	1	0	0	0	0	0	0	0	1	4707	1606	56	5		5	DOCK10	2	225651808	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	1189030	225651808	17547565	69	10802											
AGFG1	3267	broad.mit.edu	37	chr2	228337216	228337216	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccggcctcccgcacaacCgaaagtgcttcgactgcgac	9	6	10	16	5	0	1	0	1	0	0	2	4	1	1	4	1	3	2	4	1	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr2:228337216C>G	uc002vpc.2	+	1	329	c.79C>G	c.(79-81)CGA>GGA	p.R27G	AGFG1_uc002vpd.2_Missense_Mutation_p.R27G|AGFG1_uc002vpe.2_Missense_Mutation_p.R27G|AGFG1_uc002vpf.2_Missense_Mutation_p.R27G	NM_004504	NP_004495	P52594	AGFG1_HUMAN	HIV-1 Rev binding protein isoform 2	27	Arf-GAP.				cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CCCGCACAACCGAAAGTGCTT	0.662													13	11					0	0	0	0	G	228337216	G	G	228337216	3	3	55	1	0	0	0	0	1	0	0	0	380	644	23	3	81	3	AGFG1	2	228337216	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2685408	228337216	14862157	70	10803											
CNTN4	152330	broad.mit.edu	37	chr3	2778011	2778011	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaagttaaaggaaatccAaaacctcatatcaggtttgt	15	12	8	6	0	2	1	2	1	0	0	3	2	3	2	2	2	1	2	2	2	7	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:2778011A>T	uc003bpc.2	+	4	389	c.168A>T	c.(166-168)CCA>CCT	p.P56P	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Silent_p.P56P	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	56	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AAGGAAATCCAAAACCTCATA	0.338													32	105					0	0	0	0	T	2778011	T	T	2778011	2	4	55	1	0	0	0	0	0	0	0	1	3658	117	5	5		5	CNTN4	3	2778011	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08		2778011	195244419	71	10804											
WNT7A	7476	broad.mit.edu	37	chr3	13916474	13916474	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccttcccgaagacggtgcGctctcccagtgcagagcagt	7	8	11	15	3	1	2	0	0	1	2	4	3	3	2	3	1	3	3	3	1	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:13916474G>A	uc003bye.1	-	2	573	c.268C>T	c.(268-270)CGC>TGC	p.R90C		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	90					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						AAGACGGTGCGCTCTCCCAGT	0.582													15	38					0	0	0	0	A	13916474	A	A	13916474	3	1	55	1	0	0	0	0	1	0	0	0	17462	1087	38	1	793	1	WNT7A	3	13916474	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	11138463	13916474	184105956	72	10805											
MYRIP	25924	broad.mit.edu	37	chr3	40275391	40275391	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcaacatctccacagaagtCctgaaagtcatcaatgccac	14	8	6	13	0	3	2	2	1	1	1	5	2	4	2	3	0	3	1	3	0	4	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:40275391C>A	uc003cka.2	+	12	2082	c.1947C>A	c.(1945-1947)GTC>GTA	p.V649V	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Intron|MYRIP_uc010hhw.2_Silent_p.V560V|MYRIP_uc011ayz.1_Silent_p.V462V|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	649	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		CCACAGAAGTCCTGAAAGTCA	0.488													26	81					3.01185e-09	3.33745e-09	1	0	A	40275391	A	A	40275391	2	1	55	1	0	0	0	0	0	0	0	1	10153	842	30	2		2	MYRIP	3	40275391	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	26358917	40275391	157747039	73	10806											
STAB1	23166	broad.mit.edu	37	chr3	52558127	52558127	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcccaggcggaagatgaTgctgatgacgacttctcacc	9	9	11	12	2	1	4	1	3	1	1	3	6	2	5	2	2	2	2	2	2	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:52558127T>C	uc003dej.2	+	68	7628	c.7554T>C	c.(7552-7554)GAT>GAC	p.D2518D	STAB1_uc003del.2_Silent_p.D430D	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2518	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CGGAAGATGATGCTGATGACG	0.617													38	236					0	0	0	0	C	52558127	C	C	52558127	2	2	55	1	0	0	0	0	0	0	0	1	15303	1461	51	5		5	STAB1	3	52558127	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	12282736	52558127	145464303	74	10807											
FAM19A1	407738	broad.mit.edu	37	chr3	68055801	68055801	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcgatgtcctgggtccTgtatttgtggataagtgctt	5	16	12	8	1	1	0	0	0	1	0	3	2	3	1	2	2	2	2	2	2	2	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:68055801T>C	uc003dnd.2	+	2	248	c.32T>C	c.(31-33)CTG>CCG	p.L11P	FAM19A1_uc003dne.2_Missense_Mutation_p.L11P|FAM19A1_uc003dng.2_Missense_Mutation_p.L11P|FAM19A1_uc003dnf.1_RNA	NM_213609	NP_998774	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine	11						endoplasmic reticulum|extracellular region				ovary(1)	1		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		TCCTGGGTCCTGTATTTGTGG	0.522													31	224					0	0	0	0	C	68055801	C	C	68055801	3	2	55	1	0	0	0	0	1	0	0	0	5559	1580	55	5	34	5	FAM19A1	3	68055801	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	15497674	68055801	129966629	75	10808											
PDZRN3	23024	broad.mit.edu	37	chr3	73433788	73433788	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggagctcgcggaagcgctcGcactcgtccaccgggatccc	7	5	13	16	6	0	0	0	0	0	0	5	3	2	3	3	3	2	3	3	3	1	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:73433788G>A	uc003dpl.1	-	10	2025	c.1929C>T	c.(1927-1929)TGC>TGT	p.C643C	PDZRN3_uc011bgh.1_Silent_p.C300C|PDZRN3_uc010hoe.1_Silent_p.C341C|PDZRN3_uc011bgf.1_Silent_p.C360C|PDZRN3_uc011bgg.1_Silent_p.C363C	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	643							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GGAAGCGCTCGCACTCGTCCA	0.657													34	109					0	0	0	0	A	73433788	A	A	73433788	2	1	55	1	0	0	0	0	0	0	0	1	11763	1079	38	1		1	PDZRN3	3	73433788	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	5377987	73433788	124588642	76	10809											
ROBO2	6092	broad.mit.edu	37	chr3	77089996	77089996	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttatatgttcgggttgaTggtaagttaaaaatgctttc	10	19	9	3	1	0	1	0	1	0	0	2	1	0	1	0	2	1	5	0	2	6	9			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:77089996T>A	uc003dpy.3	+	1	703	c.60T>A	c.(58-60)GAT>GAA	p.D20E	ROBO2_uc003dpz.2_Missense_Mutation_p.D20E|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.D20E	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	20					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TTCGGGTTGATGGTAAGTTAA	0.363													31	229					0	0	0	0	A	77089996	A	A	77089996	3	1	55	1	0	0	0	0	1	0	0	0	13579	1478	51	5	62	5	ROBO2	3	77089996	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	3656208	77089996	120932434	77	10810											
OR5K2	402135	broad.mit.edu	37	chr3	98217106	98217106	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctgtgttgaccctttcatCaatgaactggttctattcat	8	17	6	10	0	4	2	3	2	1	0	5	2	5	2	2	1	1	2	2	1	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:98217106C>T	uc011bgx.1	+	1	582	c.582C>T	c.(580-582)ATC>ATT	p.I194I		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						ACCCTTTCATCAATGAACTGG	0.353													204	360					0	0	0	0	T	98217106	T	T	98217106	2	4	55	1	0	0	0	0	0	0	0	1	11221	816	29	2		2	OR5K2	3	98217106	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	21127110	98217106	99805324	78	10811											
ARHGAP31	57514	broad.mit.edu	37	chr3	119133831	119133831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcctgaaaggggcagaggctCctcccaaccagaagggacca	12	3	13	13	0	0	3	0	1	0	2	2	4	2	4	5	4	1	2	5	4	3	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:119133831C>T	uc003ecj.3	+	12	3587	c.3055C>T	c.(3055-3057)CCT>TCT	p.P1019S		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1019					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						GGCAGAGGCTCCTCCCAACCA	0.592													21	95					0	0	0	0	T	119133831	T	T	119133831	3	4	55	1	0	0	0	0	1	0	0	0	880	855	30	2	3101	2	ARHGAP31	3	119133831	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	20916725	119133831	78888599	79	10812											
KALRN	8997	broad.mit.edu	37	chr3	124438313	124438313	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccgggtgaaccaagggaCgtagccatctcccagcccct	10	5	10	16	2	1	1	0	1	1	0	2	2	1	2	6	2	4	1	6	2	4	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:124438313C>T	uc003ehg.2	+	60	9084	c.8957C>T	c.(8956-8958)ACG>ATG	p.T2986M	KALRN_uc003ehk.2_Missense_Mutation_p.T1289M	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2985					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AACCAAGGGACGTAGCCATCT	0.483													32	48					0	0	0	0	T	124438313	T	T	124438313	3	4	55	1	0	0	0	0	1	0	0	0	8014	536	19	1	9351	1	KALRN	3	124438313	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	5304482	124438313	73584117	80	10813											
SLC41A3	54946	broad.mit.edu	37	chr3	125735640	125735640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatcttcacgatgggtgggCtctgcttggcaatgaggacc	7	10	15	9	1	3	1	1	1	2	0	3	4	3	3	1	5	1	3	1	5	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:125735640C>T	uc003eij.2	-	7	1050	c.824G>A	c.(823-825)AGC>AAC	p.S275N	SLC41A3_uc003eii.2_Missense_Mutation_p.S249N|SLC41A3_uc003eil.2_Missense_Mutation_p.S275N|SLC41A3_uc003eik.2_Missense_Mutation_p.S239N|SLC41A3_uc011bkh.1_Missense_Mutation_p.S158N|SLC41A3_uc010hsd.1_Missense_Mutation_p.S290N	NM_001008485	NP_001008485	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3 isoform 1	275						integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(114;0.167)		GATGGGTGGGCTCTGCTTGGC	0.587													4	122					0	0	0	0	T	125735640	T	T	125735640	3	4	55	1	0	0	0	0	1	0	0	0	14695	797	28	4	821	4	SLC41A3	3	125735640	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	1297327	125735640	72286790	81	10814											
KIAA1257	57501	broad.mit.edu	37	chr3	128711936	128711937	+	Frame_Shift_Ins	INS	-	G	G																															gaatttgcaggggaccacgtINSggggcacgtcggagctgaaa																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:128711936_128711937insG	uc003elj.3	-	2	407_408	c.211_212insC	c.(211-213)CACfs	p.H71fs	KIAA1257_uc003elg.1_Frame_Shift_Ins_p.H71fs|KIAA1257_uc003eli.3_5'Flank	NM_020741	NP_065792	Q9ULG3	K1257_HUMAN	hypothetical protein LOC57501	71											0						GGGGACCACGTGGGGCACGTCG	0.574													---	---	---								G	128711937	G	G	128711936	7	5	55	1	0	1	1	0	0	0	0	0	8257	1696	59	0	1045	0	KIAA1257	3	128711936	Frame_Shift_Ins	INS	-	TCGA-CN-5356-01A-01D-1434-08	2976296	128711936	69310494	82	10815											
CPNE4	131034	broad.mit.edu	37	chr3	131404769	131404769	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcatcattcatacgaaaaaTttccagaaatgggtcagatt	16	12	6	7	1	4	2	4	0	0	2	5	3	5	2	1	1	1	0	1	1	4	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:131404769T>A	uc003eok.2	-	6	976	c.541A>T	c.(541-543)ATT>TTT	p.I181F	CPNE4_uc011blq.1_Missense_Mutation_p.I199F|CPNE4_uc003eol.2_Missense_Mutation_p.I199F|CPNE4_uc003eom.2_Missense_Mutation_p.I181F	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	181	C2 2.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ATACGAAAAATTTCCAGAAAT	0.383													17	62					0	0	0	0	A	131404769	A	A	131404769	3	1	55	1	0	0	0	0	1	0	0	0	3829	1493	52	5	1176	5	CPNE4	3	131404769	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	2692833	131404769	66617661	83	10816											
EPHB1	2047	broad.mit.edu	37	chr3	134851723	134851723	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcccgctgtgacgacaatGtggagtttgtgcccaggcag	7	9	14	11	2	0	1	0	1	0	0	1	3	1	2	2	2	1	4	2	2	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:134851723G>C	uc003eqt.2	+	5	1349	c.1129G>C	c.(1129-1131)GTG>CTG	p.V377L	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	377	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TGACGACAATGTGGAGTTTGT	0.617													5	53					0	0	0	0	C	134851723	C	C	134851723	3	2	55	1	0	0	0	0	1	0	0	0	5198	1377	48	4	1147	4	EPHB1	3	134851723	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	3446954	134851723	63170707	84	10817											
CLSTN2	64084	broad.mit.edu	37	chr3	140123507	140123507	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagatctatgacagcattcTgcaggtggaggccattgacg	11	9	12	9	1	2	3	0	2	2	1	2	4	2	4	1	3	2	2	1	3	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:140123507T>C	uc003etn.2	+	4	726	c.536T>C	c.(535-537)CTG>CCG	p.L179P	CLSTN2_uc003etm.2_Missense_Mutation_p.L179P	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	179	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GACAGCATTCTGCAGGTGGAG	0.507										HNSCC(16;0.037)			40	143					0	0	0	0	C	140123507	C	C	140123507	3	2	55	1	0	0	0	0	1	0	0	0	3577	1580	55	5	550	5	CLSTN2	3	140123507	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	5271784	140123507	57898923	85	10818											
XRN1	54464	broad.mit.edu	37	chr3	142141448	142141448	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagttctggcaggatggtaaCatatgttccataaagaagag	15	10	11	5	0	1	2	0	0	1	2	2	3	2	3	1	3	1	4	1	3	6	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:142141448C>T	uc003eus.2	-	8	1010	c.943G>A	c.(943-945)GTT>ATT	p.V315I	XRN1_uc003eut.2_Missense_Mutation_p.V315I|XRN1_uc003euu.2_Missense_Mutation_p.V315I|XRN1_uc003euv.1_Missense_Mutation_p.V176I|XRN1_uc003euw.2_Missense_Mutation_p.V315I|XRN1_uc011bnh.1_Missense_Mutation_p.V105I	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	315					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						AGGATGGTAACATATGTTCCA	0.358													74	128					0	0	0	0	T	142141448	T	T	142141448	3	4	55	1	0	0	0	0	1	0	0	0	17527	478	17	4	4317	4	XRN1	3	142141448	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2017941	142141448	55880982	86	10819											
ATR	545	broad.mit.edu	37	chr3	142217599	142217599	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcccagtctgacactccAtgttgtagattttccatctg	7	15	7	12	0	2	2	0	1	2	1	5	2	5	2	3	0	0	2	3	0	1	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:142217599A>T	uc003eux.3	-	32	5520	c.5398T>A	c.(5398-5400)TGG>AGG	p.W1800R		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1800	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CTGACACTCCATGTTGTAGAT	0.378								Other_conserved_DNA_damage_response_genes					36	65					0	0	0	0	T	142217599	T	T	142217599	3	4	55	1	0	0	0	0	1	0	0	0	1206	217	8	5	2600	5	ATR	3	142217599	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	76151	142217599	55804831	87	10820											
PLOD2	5352	broad.mit.edu	37	chr3	145828169	145828169	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatctgctgcaaagaccacTttgtggtttgccttttggaa	8	14	9	10	0	1	1	0	0	1	1	1	2	1	2	3	2	3	3	3	2	2	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:145828169T>G	uc003evs.1	-	4	911	c.405A>C	c.(403-405)AAA>AAC	p.K135N	PLOD2_uc011bnm.1_Missense_Mutation_p.K80N|PLOD2_uc003evr.1_Missense_Mutation_p.K135N	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	135					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	CAAAGACCACTTTGTGGTTTG	0.388													39	117					0	0	0	0	G	145828169	G	G	145828169	3	3	55	1	0	0	0	0	1	0	0	0	12157	1606	56	5	1939	5	PLOD2	3	145828169	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	3610570	145828169	52194261	88	10821											
CPB1	1360	broad.mit.edu	37	chr3	148558763	148558763	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcgctatttacctcctgaagGtaatcatttttaaccatgac	11	14	6	10	1	1	2	1	2	0	0	2	2	2	2	3	1	2	2	3	1	5	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:148558763G>T	uc003ewl.2	+	5	497	c.474_splice	c.e5+1	p.K158_splice		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein						proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CCTCCTGAAGGTAATCATTTT	0.443													24	121					5.35356e-11	6.09711e-11	1	0	T	148558763	T	T	148558763	5	4	55	1	0	0	0	0	0	0	1	0	3811	1275	44	4	493	4	CPB1	3	148558763	Splice_Site	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2730594	148558763	49463667	89	10822											
DHX36	170506	broad.mit.edu	37	chr3	154013097	154013097	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctggttaactgtaggcatCagtgaatgtaaaggtataat	13	13	11	4	0	2	1	1	1	1	0	2	1	2	1	0	3	1	5	0	3	7	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:154013097C>T	uc003ezy.3	-	13	1662	c.1581G>A	c.(1579-1581)CTG>CTA	p.L527L	DHX36_uc010hvq.2_Intron|DHX36_uc003ezz.3_Silent_p.L527L	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	527	Nuclear localization signal.|Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CTGTAGGCATCAGTGAATGTA	0.303													14	39					0	0	0	0	T	154013097	T	T	154013097	2	4	55	1	0	0	0	0	0	0	0	1	4531	813	29	2		2	DHX36	3	154013097	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	5454334	154013097	44009333	90	10823											
GPR149	344758	broad.mit.edu	37	chr3	154055728	154055728	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttctttcctggagtaacgTagggatggagatctgacttg	8	15	12	6	1	2	2	0	1	2	1	3	5	3	4	1	3	1	2	1	3	2	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:154055728T>A	uc003faa.2	-	4	2056	c.1956A>T	c.(1954-1956)CTA>CTT	p.L652L		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	652	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGGAGTAACGTAGGGATGGAG	0.428													77	251					0	0	0	0	A	154055728	A	A	154055728	2	1	55	1	0	0	0	0	0	0	0	1	6692	1625	57	5		5	GPR149	3	154055728	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	42631	154055728	43966702	91	10824											
MME	4311	broad.mit.edu	37	chr3	154859798	154859798	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccattcagctggttgaatTtcacaaatgaaatcatgtca	14	12	7	8	0	4	2	4	2	0	0	4	2	4	2	1	1	2	2	1	1	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:154859798T>G	uc010hvr.1	+	11	1187	c.976T>G	c.(976-978)TTC>GTC	p.F326V	MME_uc003fab.1_Missense_Mutation_p.F326V|MME_uc003fac.1_Missense_Mutation_p.F326V|MME_uc003fad.1_Missense_Mutation_p.F326V|MME_uc003fae.1_Missense_Mutation_p.F326V	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	326	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CTGGTTGAATTTCACAAATGA	0.358													58	133					0	0	0	0	G	154859798	G	G	154859798	3	3	55	1	0	0	0	0	1	0	0	0	9698	1841	64	5	1014	5	MME	3	154859798	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	804070	154859798	43162632	92	10825											
RSRC1	51319	broad.mit.edu	37	chr3	158072664	158072664	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccaccagctgaacaggccAaagccagactacagctggtt	13	5	10	13	0	0	2	0	1	0	1	0	2	0	2	4	2	6	3	4	2	3	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:158072664A>C	uc003fbt.2	+	6	661	c.550A>C	c.(550-552)AAA>CAA	p.K184Q	RSRC1_uc011bou.1_Missense_Mutation_p.K126Q|RSRC1_uc003fbu.1_Missense_Mutation_p.K184Q|RSRC1_uc003fbv.2_Missense_Mutation_p.K126Q	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	184	Potential.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			TGAACAGGCCAAAGCCAGACT	0.358													6	30					0	0	0	0	C	158072664	C	C	158072664	3	2	55	1	0	0	0	0	1	0	0	0	13779	131	5	5	568	5	RSRC1	3	158072664	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	3212866	158072664	39949766	93	10826											
PEX5L	51555	broad.mit.edu	37	chr3	179593166	179593166	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagctcttttgatccagttCtagatgaggatgattttctc	9	16	9	7	0	3	5	0	3	3	2	5	6	4	6	1	1	1	2	1	1	1	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:179593166C>G	uc003fki.1	-	6	735	c.605G>C	c.(604-606)AGA>ACA	p.R202T	PEX5L_uc011bqd.1_Missense_Mutation_p.R159T|PEX5L_uc011bqe.1_Missense_Mutation_p.R10T|PEX5L_uc011bqf.1_Missense_Mutation_p.R94T|PEX5L_uc003fkj.1_Missense_Mutation_p.R167T|PEX5L_uc010hxd.1_Missense_Mutation_p.R200T|PEX5L_uc011bqg.1_Missense_Mutation_p.R178T|PEX5L_uc011bqh.1_Missense_Mutation_p.R143T	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	202					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TGATCCAGTTCTAGATGAGGA	0.378													43	202					0	0	0	0	G	179593166	G	G	179593166	3	3	55	1	0	0	0	0	1	0	0	0	11804	913	32	2	1315	2	PEX5L	3	179593166	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	21520502	179593166	18429264	94	10827											
CRYGS	1427	broad.mit.edu	37	chr3	186257301	186257301	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccactttaatggagttgcagCgacttaggtatgtgtggaaa	11	12	12	6	1	0	0	0	0	0	0	0	3	0	2	1	3	2	3	1	3	4	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:186257301C>T	uc003fqe.2	-	2	159	c.107G>A	c.(106-108)CGC>CAC	p.R36H	CRYGS_uc003fqf.2_Missense_Mutation_p.R36H	NM_017541	NP_060011	P22914	CRBS_HUMAN	crystallin, gamma S	36	Beta/gamma crystallin 'Greek key' 1.						structural constituent of eye lens				0	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		GGAGTTGCAGCGACTTAGGTA	0.463													38	138					0	0	0	0	T	186257301	T	T	186257301	3	4	55	1	0	0	0	0	1	0	0	0	3934	768	27	1	437	1	CRYGS	3	186257301	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	6664135	186257301	11765129	95	10828											
ATP13A5	344905	broad.mit.edu	37	chr3	193007781	193007782	+	Frame_Shift_Ins	INS	-	G	G																															aaaatattgaaagcagtaaaINSgggggagaaaggagctgtcc																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr3:193007781_193007782insG	uc011bsq.1	-	26	2915_2916	c.2915_2916insC	c.(2914-2916)CCTfs	p.P972fs		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	972					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		AAAGCAGTAAAGGGGGAGAAAG	0.421													---	---	---								G	193007782	G	G	193007781	7	5	55	1	0	1	1	0	0	0	0	0	1129	59	3	0	758	0	ATP13A5	3	193007781	Frame_Shift_Ins	INS	-	TCGA-CN-5356-01A-01D-1434-08	6750480	193007781	5014649	96	10829											
DGKQ	1609	broad.mit.edu	37	chr4	954932	954932	+	Frame_Shift_Del	DEL	G	-	-																															ggccttgaggagcgtgactcGgaagtaggaaccctgggcaa																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:954932delG	uc003gbw.2	-	22	2706	c.2632delC	c.(2632-2634)CGAfs	p.R878fs	DGKQ_uc010ibn.2_Frame_Shift_Del_p.R865fs	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	878					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			AGCGTGACTCGGAAGTAGGAA	0.692													---	---	---								-	954932	-	-	954932	7	5	55	1	0	1	0	1	0	0	0	0	4495	1124	39	0	204	0	DGKQ	4	954932	Frame_Shift_Del	DEL	G	TCGA-CN-5356-01A-01D-1434-08		954932	190199344	97	10830											
SLIT2	9353	broad.mit.edu	37	chr4	20550181	20550181	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatgacccagctcctcaccTtgtgagtgtgaaagtgtggt	9	11	11	10	0	1	3	1	3	0	0	2	3	2	3	3	1	1	1	3	1	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:20550181T>A	uc003gpr.1	+	23	2620	c.2416T>A	c.(2416-2418)TTA>ATA	p.L806I	SLIT2_uc003gps.1_Missense_Mutation_p.L798I	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	806	LRR 19.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						GCTCCTCACCTTGTGAGTGTG	0.284													28	72					0	0	0	0	A	20550181	A	A	20550181	3	1	55	1	0	0	0	0	1	0	0	0	14804	1623	56	5	2506	5	SLIT2	4	20550181	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	19595249	20550181	170604095	98	10831											
GBA3	57733	broad.mit.edu	37	chr4	22694648	22694648	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcttaaaccatggctttcCctgcaggatttggatgggcg	7	13	11	10	1	1	0	0	0	1	0	2	2	2	2	2	4	2	2	2	4	2	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:22694648C>A	uc003gqp.3	+	1	101	c.10C>A	c.(10-12)CCT>ACT	p.P4T	GBA3_uc010iep.2_Missense_Mutation_p.P4T	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	4					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						CATGGCTTTCCCTGCAGGATT	0.527													5	13					1.23904e-05	1.32523e-05	1	0	A	22694648	A	A	22694648	3	1	55	1	0	0	0	0	1	0	0	0	6303	623	22	4	12	4	GBA3	4	22694648	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2144467	22694648	168459628	99	10832											
PCDH7	5099	broad.mit.edu	37	chr4	31144302	31144302	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccgccatcatgggtgaccGcaacagaaacctcctgaaca	12	5	10	14	2	1	3	1	2	0	1	2	3	2	3	5	2	3	1	5	2	3	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:31144302G>T	uc011bxx.1	+	3	4583	c.3575G>T	c.(3574-3576)CGC>CTC	p.R1192L	PCDH7_uc011bxw.1_Missense_Mutation_p.R1145L	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	Error:Variant_position_missing_in_O60245_after_alignment					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						ATGGGTGACCGCAACAGAAAC	0.502													18	139					1.56452e-12	1.81544e-12	1	0	T	31144302	T	T	31144302	3	4	55	1	0	0	0	0	1	0	0	0	11570	1087	38	3	3694	3	PCDH7	4	31144302	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	8449654	31144302	160009974	100	10833											
SHISA3	152573	broad.mit.edu	37	chr4	42403085	42403085	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcattgcgttcatcatcCtgggctctgtagtggctatt	5	17	9	10	1	5	0	3	0	2	0	6	0	6	0	1	2	1	4	1	2	2	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:42403085C>G	uc003gwp.2	+	2	552	c.334C>G	c.(334-336)CTG>GTG	p.L112V		NM_001080505	NP_001073974	A0PJX4	SHSA3_HUMAN	shisa homolog 3 precursor	112	Helical; (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|skin(1)	2						GTTCATCATCCTGGGCTCTGT	0.502													78	235					0	0	0	0	G	42403085	G	G	42403085	3	3	55	1	0	0	0	0	1	0	0	0	14346	680	24	4	340	4	SHISA3	4	42403085	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	11258783	42403085	148751191	101	10834											
GRXCR1	389207	broad.mit.edu	37	chr4	42964954	42964954	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgtgtagtgatttataccAcctgccttcgtgtggtccgg	6	13	11	11	3	0	1	0	1	0	0	2	1	1	1	5	2	2	1	5	2	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:42964954A>T	uc003gwt.2	+	2	430	c.430A>T	c.(430-432)ACC>TCC	p.T144S		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	144	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						GATTTATACCACCTGCCTTCG	0.383													58	250					0	0	0	0	T	42964954	T	T	42964954	3	4	55	1	0	0	0	0	1	0	0	0	6851	159	6	5	436	5	GRXCR1	4	42964954	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	561869	42964954	148189322	102	10835											
LPHN3	23284	broad.mit.edu	37	chr4	62897294	62897294	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caattctctacagggaatgtTtatatttattttccattgtg	10	19	6	6	0	1	0	0	0	1	0	3	1	2	1	1	1	1	1	1	1	6	10			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:62897294T>C	uc010ihh.2	+	20	3526	c.3353T>C	c.(3352-3354)TTT>TCT	p.F1118S	LPHN3_uc003hcq.3_Missense_Mutation_p.F1118S|LPHN3_uc003hct.2_Missense_Mutation_p.F502S	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1096	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CAGGGAATGTTTATATTTATT	0.348													22	106					0	0	0	0	C	62897294	C	C	62897294	3	2	55	1	0	0	0	0	1	0	0	0	8967	1841	64	5	3431	5	LPHN3	4	62897294	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	19932340	62897294	128256982	103	10836											
TIGD2	166815	broad.mit.edu	37	chr4	90034966	90034966	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagaagcatttgaaatccAagggacttttagaaaaagca	18	9	8	6	0	0	3	0	1	0	2	1	4	1	4	1	1	3	2	1	1	7	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:90034966A>C	uc003hsk.2	+	1	999	c.841A>C	c.(841-843)AAG>CAG	p.K281Q	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	281	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		TTTGAAATCCAAGGGACTTTT	0.373													21	89					0	0	0	0	C	90034966	C	C	90034966	3	2	55	1	0	0	0	0	1	0	0	0	15962	131	5	5	843	5	TIGD2	4	90034966	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	27137672	90034966	101119310	104	10837											
GPRIN3	285513	broad.mit.edu	37	chr4	90170592	90170592	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagtcacagatggctccctGcctttccccttcaggtccac	7	10	8	16	0	2	2	2	0	0	2	5	2	5	2	5	2	1	1	5	2	0	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:90170592G>T	uc003hsm.1	-	2	1189	c.670C>A	c.(670-672)CAG>AAG	p.Q224K		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	224										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		ATGGCTCCCTGCCTTTCCCCT	0.537													41	80					4.14481e-20	5.12373e-20	1	0	T	90170592	T	T	90170592	3	4	55	1	0	0	0	0	1	0	0	0	6770	1328	46	4	1664	4	GPRIN3	4	90170592	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	135626	90170592	100983684	105	10838											
SEC24B	10427	broad.mit.edu	37	chr4	110445990	110445990	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttaggtggtacaacatcttgGccctgcaactgatttttata	10	15	8	8	0	1	1	0	1	1	0	1	1	1	1	1	3	4	2	1	3	6	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:110445990G>A	uc003hzk.2	+	15	2580	c.2525G>A	c.(2524-2526)GGC>GAC	p.G842D	SEC24B_uc003hzl.2_Missense_Mutation_p.G807D|SEC24B_uc011cfp.1_Missense_Mutation_p.G872D|SEC24B_uc011cfq.1_Missense_Mutation_p.G841D|SEC24B_uc011cfr.1_Missense_Mutation_p.G806D	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	842					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CAACATCTTGGCCCTGCAACT	0.358													35	113					0	0	0	0	A	110445990	A	A	110445990	3	1	55	1	0	0	0	0	1	0	0	0	14060	1203	42	4	2583	4	SEC24B	4	110445990	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	20275398	110445990	80708286	106	10839											
ANK2	287	broad.mit.edu	37	chr4	114278087	114278087	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacactgatcagccaaaaatCtgtgatggccatggatgtga	13	9	11	8	0	2	3	1	3	1	0	2	5	2	4	2	2	1	0	2	2	2	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:114278087C>T	uc003ibe.3	+	38	8413	c.8313C>T	c.(8311-8313)ATC>ATT	p.I2771I	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Silent_p.I73I|ANK2_uc011cgb.1_Silent_p.I2786I	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2738					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGCCAAAAATCTGTGATGGCC	0.478													21	86					0	0	0	0	T	114278087	T	T	114278087	2	4	55	1	0	0	0	0	0	0	0	1	621	903	32	2		2	ANK2	4	114278087	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3832097	114278087	76876189	107	10840											
KIAA1109	84162	broad.mit.edu	37	chr4	123113395	123113395	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggaatataggacttgttccgGaagaaacagaagaaaatatt	18	9	10	4	1	0	3	0	0	0	3	1	6	1	6	1	3	1	1	1	3	9	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:123113395G>C	uc003ieh.2	+	9	958	c.913G>C	c.(913-915)GAA>CAA	p.E305Q	KIAA1109_uc003iei.1_Missense_Mutation_p.E59Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	305					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						ACTTGTTCCGGAAGAAACAGA	0.318													14	53					0	0	0	0	C	123113395	C	C	123113395	3	2	55	1	0	0	0	0	1	0	0	0	8247	1175	41	2	947	2	KIAA1109	4	123113395	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	8835308	123113395	68040881	108	10841											
IL21	59067	broad.mit.edu	37	chr4	123542011	123542011	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcttaccaagtcattcacAtaatttttcagctgatcaac	13	14	4	10	0	5	1	4	1	1	0	5	1	5	1	1	0	3	1	1	0	4	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:123542011A>G	uc003ies.2	-	1	201	c.156T>C	c.(154-156)TAT>TAC	p.Y52Y	uc003iet.2_Intron|IL21_uc010int.2_Silent_p.Y45Y	NM_021803	NP_068575	Q9HBE4	IL21_HUMAN	interleukin 21	45					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding				0						AGTCATTCACATAATTTTTCA	0.343													35	103					0	0	0	0	G	123542011	G	G	123542011	2	3	55	1	0	0	0	0	0	0	0	1	7709	224	8	5		5	IL21	4	123542011	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	428616	123542011	67612265	109	10842											
FGF2	2247	broad.mit.edu	37	chr4	123748456	123748456	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgggggcttcttcctgcgcAtccaccccgacggccgagtt	5	8	12	16	5	1	0	0	0	1	0	3	2	3	0	5	3	1	3	5	3	0	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:123748456A>T	uc003iev.1	+	1	594	c.526A>T	c.(526-528)ATC>TTC	p.I176F		NM_002006	NP_001997	P09038	FGF2_HUMAN	fibroblast growth factor 2	176					activation of MAPK activity|branching involved in ureteric bud morphogenesis|cell migration involved in sprouting angiogenesis|chemotaxis|chondroblast differentiation|embryonic morphogenesis|fibroblast growth factor receptor signaling pathway|inositol phosphate biosynthetic process|insulin receptor signaling pathway|negative regulation of blood vessel endothelial cell migration|negative regulation of cell death|organ morphogenesis|phosphatidylinositol biosynthetic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cardiac muscle cell proliferation|positive regulation of cell division|positive regulation of cell fate specification|positive regulation of ERK1 and ERK2 cascade|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phospholipase C activity|Ras protein signal transduction|release of sequestered calcium ion into cytosol|wound healing	extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|lung(1)|central_nervous_system(1)	3					Pentosan Polysulfate(DB00686)	CTTCCTGCGCATCCACCCCGA	0.667													18	49					0	0	0	0	T	123748456	T	T	123748456	3	4	55	1	0	0	0	0	1	0	0	0	5880	217	8	5	528	5	FGF2	4	123748456	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	206445	123748456	67405820	110	10843											
FAT4	79633	broad.mit.edu	37	chr4	126238150	126238150	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catcaccctgaacccgagcgGcgagggagcgttcctgcatc	8	6	12	15	4	1	1	1	1	0	0	3	4	2	2	3	2	4	2	3	2	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:126238150G>T	uc003ifj.3	+	1	584	c.584G>T	c.(583-585)GGC>GTC	p.G195V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	195	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AACCCGAGCGGCGAGGGAGCG	0.642											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	41					0.000673444	0.00070198	1	0	T	126238150	T	T	126238150	3	4	55	1	0	0	0	0	1	0	0	0	5724	1203	42	4	586	4	FAT4	4	126238150	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2489694	126238150	64916126	111	10844											
PCDH18	54510	broad.mit.edu	37	chr4	138452014	138452014	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaataattgttttcatatGtcttctgaagtttaaagtga	13	19	6	3	0	3	2	1	2	2	0	3	2	3	2	0	0	0	2	0	0	7	9			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:138452014G>A	uc003ihe.3	-	1	1616	c.1229C>T	c.(1228-1230)ACA>ATA	p.T410I	PCDH18_uc003ihf.3_Missense_Mutation_p.T403I|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.T190I|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	410	Cadherin 4.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					GTTTTCATATGTCTTCTGAAG	0.393													31	150					0	0	0	0	A	138452014	A	A	138452014	3	1	55	1	0	0	0	0	1	0	0	0	11567	1377	48	4	2194	4	PCDH18	4	138452014	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	12213864	138452014	52702262	112	10845											
ELF2	1998	broad.mit.edu	37	chr4	139981705	139981705	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatcagtagttcctgctaaAtcttcattacaggtttcact	10	16	5	10	0	5	0	4	0	1	0	6	0	6	0	1	1	2	4	1	1	4	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:139981705A>G	uc003ihp.1	-	8	1100	c.894T>C	c.(892-894)GAT>GAC	p.D298D	ELF2_uc003ihm.1_Silent_p.D250D|ELF2_uc003ihn.1_Silent_p.D238D|ELF2_uc003iho.1_Silent_p.D221D|ELF2_uc011chc.1_Silent_p.D113D	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	310					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					TTCCTGCTAAATCTTCATTAC	0.393													48	211					0	0	0	0	G	139981705	G	G	139981705	2	3	55	1	0	0	0	0	0	0	0	1	5078	98	4	5		5	ELF2	4	139981705	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	1529691	139981705	51172571	113	10846											
ZNF330	27309	broad.mit.edu	37	chr4	142155086	142155086	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagatttgtttactaatttGaatttaggaaggacctatgc	12	16	8	5	0	1	2	1	1	0	1	1	4	1	4	1	2	2	1	1	2	6	8			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:142155086G>T	uc003iiq.3	+	10	1126	c.906G>T	c.(904-906)TTG>TTT	p.L302F	ZNF330_uc011chl.1_Missense_Mutation_p.L242F	NM_014487	NP_055302	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	302						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)					TTACTAATTTGAATTTAGGAA	0.338													20	107					4.26978e-12	4.91974e-12	1	0	T	142155086	T	T	142155086	3	4	55	1	0	0	0	0	1	0	0	0	17915	1281	45	2	940	2	ZNF330	4	142155086	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2173381	142155086	48999190	114	10847											
NR3C2	4306	broad.mit.edu	37	chr4	149357710	149357710	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tataaacccatggactcagcTacagttgctgaaagttcctt	12	12	7	10	0	1	1	1	1	0	0	2	2	2	2	2	1	4	4	2	1	5	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:149357710T>C	uc003ilj.3	-	2	637	c.303A>G	c.(301-303)GTA>GTG	p.V101V	NR3C2_uc003ilk.3_Silent_p.V101V|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	101	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TGGACTCAGCTACAGTTGCTG	0.408													43	166					0	0	0	0	C	149357710	C	C	149357710	2	2	55	1	0	0	0	0	0	0	0	1	10685	1509	53	5		5	NR3C2	4	149357710	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	7202624	149357710	41796566	115	10848											
RNF175	285533	broad.mit.edu	37	chr4	154649396	154649396	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggggttttcgggtagctcTgaagaggatgtaactggtaa	10	11	16	4	1	1	2	0	1	1	1	2	4	1	3	0	5	2	5	0	5	4	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:154649396T>C	uc003int.2	-	4	737	c.364A>G	c.(364-366)AGA>GGA	p.R122G	RNF175_uc003inu.1_Intron	NM_173662	NP_775933	Q8N4F7	RN175_HUMAN	ring finger protein 175	122						integral to membrane	zinc ion binding			ovary(1)|pancreas(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CGGGTAGCTCTGAAGAGGATG	0.428													30	69					0	0	0	0	C	154649396	C	C	154649396	3	2	55	1	0	0	0	0	1	0	0	0	13528	1588	55	5	646	5	RNF175	4	154649396	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	5291686	154649396	36504880	116	10849											
DCHS2	54798	broad.mit.edu	37	chr4	155156538	155156538	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacagtggccactggagtttGagtgtctgtacagattgaca	11	11	12	7	0	1	3	0	2	1	1	1	4	1	4	1	2	2	2	1	2	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:155156538G>C	uc003inw.2	-	25	7901	c.7901C>G	c.(7900-7902)TCA>TGA	p.S2634*		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2634					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ACTGGAGTTTGAGTGTCTGTA	0.463													45	94					0	0	0	0	C	155156538	C	C	155156538	4	2	55	1	0	0	0	0	0	1	0	0	4305	1294	45	2	853	2	DCHS2	4	155156538	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	507142	155156538	35997738	117	10850											
DCHS2	54798	broad.mit.edu	37	chr4	155156946	155156946	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgattattttcatttccaagGtgtcttctttgttgagttga	7	20	8	6	1	3	2	1	2	2	0	4	3	4	2	1	1	0	2	1	1	2	8			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:155156946G>A	uc003inw.2	-	25	7493	c.7493C>T	c.(7492-7494)ACC>ATC	p.T2498I		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2498	Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CATTTCCAAGGTGTCTTCTTT	0.368													40	151					0	0	0	0	A	155156946	A	A	155156946	3	1	55	1	0	0	0	0	1	0	0	0	4305	1261	44	4	1261	4	DCHS2	4	155156946	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	408	155156946	35997330	118	10851											
LRAT	9227	broad.mit.edu	37	chr4	155665617	155665617	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaaaccagctctttccacCgaggcgacgtgctggaggtg	9	8	13	11	3	1	1	0	1	1	0	2	4	2	2	3	3	3	2	3	3	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:155665617C>G	uc003iom.1	+	1	466	c.139C>G	c.(139-141)CGA>GGA	p.R47G	uc003iol.2_Intron|LRAT_uc003ion.1_Missense_Mutation_p.R47G	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	47	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	CTCTTTCCACCGAGGCGACGT	0.577													22	151					0	0	0	0	G	155665617	G	G	155665617	3	3	55	1	0	0	0	0	1	0	0	0	8980	644	23	3	141	3	LRAT	4	155665617	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	508671	155665617	35488659	119	10852											
GLRB	2743	broad.mit.edu	37	chr4	158065104	158065104	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgcgagtgctgccagagtGcccctgggtaaggtgttcca	7	8	15	11	2	0	1	0	0	0	1	1	3	1	1	4	2	3	3	4	2	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:158065104G>T	uc003ipj.2	+	8	1099	c.897G>T	c.(895-897)GTG>GTT	p.V299V		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	299	Helical; (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	CTGCCAGAGTGCCCCTGGGTA	0.448													19	142					6.33239e-15	7.43564e-15	1	0	T	158065104	T	T	158065104	2	4	55	1	0	0	0	0	0	0	0	1	6495	1306	46	4		4	GLRB	4	158065104	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2399487	158065104	33089172	120	10853											
GRIA2	2891	broad.mit.edu	37	chr4	158284070	158284070	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttacaagtcaagggccgaGgcgaaacgaatgaaggtggc	13	6	15	7	3	1	1	1	1	0	0	1	4	1	1	1	4	2	1	1	4	6	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:158284070G>T	uc003ipm.3	+	15	2985	c.2526G>T	c.(2524-2526)GAG>GAT	p.E842D	GRIA2_uc011cit.1_Missense_Mutation_p.E795D|GRIA2_uc003ipl.3_Missense_Mutation_p.E842D|GRIA2_uc003ipk.3_Missense_Mutation_p.E795D|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_3'UTR|GRIA2_uc011ciy.1_3'UTR|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	842	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CAAGGGCCGAGGCGAAACGAA	0.453													47	84					2.13384e-23	2.69192e-23	1	0	T	158284070	T	T	158284070	3	4	55	1	0	0	0	0	1	0	0	0	6807	991	35	4	2703	4	GRIA2	4	158284070	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	218966	158284070	32870206	121	10854											
FAM198B	51313	broad.mit.edu	37	chr4	159076818	159076818	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actcatgatgatgtatttcaGtacaacccgattcaggcttg	11	13	8	9	1	3	2	3	2	0	0	3	3	3	2	1	1	2	3	1	1	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:159076818G>A	uc003ipp.3	-	3	1522	c.1070C>T	c.(1069-1071)ACT>ATT	p.T357I	FAM198B_uc003ipq.3_Missense_Mutation_p.T365I|FAM198B_uc003ipr.3_Missense_Mutation_p.T357I	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	357	Extracellular (Potential).					Golgi membrane|integral to membrane					0						ATGTATTTCAGTACAACCCGA	0.428													4	73					0	0	0	0	A	159076818	A	A	159076818	3	1	55	1	0	0	0	0	1	0	0	0	5557	1029	36	4	501	4	FAM198B	4	159076818	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	792748	159076818	32077458	122	10855											
FAM198B	51313	broad.mit.edu	37	chr4	159076833	159076833	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcagtacaacccgattcaGgcttgggtactcggccattc	8	12	9	12	2	2	0	2	0	0	0	4	1	2	0	2	3	3	3	2	3	3	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:159076833G>C	uc003ipp.3	-	3	1507	c.1055C>G	c.(1054-1056)CCT>CGT	p.P352R	FAM198B_uc003ipq.3_Missense_Mutation_p.P360R|FAM198B_uc003ipr.3_Missense_Mutation_p.P352R	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	352	Extracellular (Potential).					Golgi membrane|integral to membrane					0						ACCCGATTCAGGCTTGGGTAC	0.413													5	72					0	0	0	0	C	159076833	C	C	159076833	3	2	55	1	0	0	0	0	1	0	0	0	5557	1000	35	4	516	4	FAM198B	4	159076833	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	15	159076833	32077443	123	10856											
TMEM144	55314	broad.mit.edu	37	chr4	159136355	159136355	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttctaggaatgtttctccAgtgggttctttgtgctgcca	6	17	10	8	0	3	0	0	0	3	0	4	1	3	1	2	2	2	3	2	2	2	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:159136355A>G	uc003ipx.2	+	4	642	c.122A>G	c.(121-123)CAG>CGG	p.Q41R	TMEM144_uc010iqi.2_RNA	NM_018342	NP_060812	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	41	Helical; (Potential).					integral to membrane					0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		ATGTTTCTCCAGTGGGTTCTT	0.388													32	222					0	0	0	0	G	159136355	G	G	159136355	3	3	55	1	0	0	0	0	1	0	0	0	16124	188	7	5	128	5	TMEM144	4	159136355	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	59522	159136355	32017921	124	10857											
ANP32C	23520	broad.mit.edu	37	chr4	165118778	165118778	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcgagtttgccttcattcGaccgactgttgtccagggca	6	13	10	12	3	1	0	1	0	0	0	4	3	2	0	3	1	1	3	3	1	0	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:165118778G>T	uc011cjk.1	-	1	86	c.86C>A	c.(85-87)TCG>TAG	p.S29*	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	29											0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		GCCTTCATTCGACCGACTGTT	0.498													68	310					1.74474e-33	2.25898e-33	1	0	T	165118778	T	T	165118778	4	4	55	1	0	0	0	0	0	1	0	0	707	1059	37	3	621	3	ANP32C	4	165118778	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	5982423	165118778	26035498	125	10858											
GALNTL6	442117	broad.mit.edu	37	chr4	173852403	173852403	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccatacaaagttccatctgGgacaagcctggcaagagtga	13	8	10	10	0	1	2	0	1	1	1	3	3	3	3	3	2	2	2	3	2	4	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:173852403G>T	uc003isv.2	+	9	1869	c.1133G>T	c.(1132-1134)GGG>GTG	p.G378V		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	378	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GTTCCATCTGGGACAAGCCTG	0.463													53	125					6.4308e-24	8.13356e-24	1	0	T	173852403	T	T	173852403	3	4	55	1	0	0	0	0	1	0	0	0	6260	1232	43	4	1163	4	GALNTL6	4	173852403	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	8733625	173852403	17301873	126	10859											
WDR17	116966	broad.mit.edu	37	chr4	177052768	177052768	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcgaagcagttccaccccCaactttaacacagaatcaag	16	6	6	13	1	1	1	1	0	0	1	2	2	2	1	3	0	4	2	3	0	6	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:177052768C>T	uc003iuj.2	+	8	1205	c.1049C>T	c.(1048-1050)CCA>CTA	p.P350L	WDR17_uc003iuk.2_Missense_Mutation_p.P326L|WDR17_uc003ium.3_Missense_Mutation_p.P326L|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	350										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GTTCCACCCCCAACTTTAACA	0.383													82	230					0	0	0	0	T	177052768	T	T	177052768	3	4	55	1	0	0	0	0	1	0	0	0	17345	594	21	4	1075	4	WDR17	4	177052768	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3200365	177052768	14101508	127	10860											
WDR17	116966	broad.mit.edu	37	chr4	177098636	177098636	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatagatcattagaagactCtccgtatacacccccttctg	12	12	5	12	1	3	3	1	0	2	3	4	3	3	3	3	0	1	1	3	0	6	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:177098636C>A	uc003iuj.2	+	30	3836	c.3680C>A	c.(3679-3681)TCT>TAT	p.S1227Y	WDR17_uc003iuk.2_Missense_Mutation_p.S1203Y|WDR17_uc003ium.3_Missense_Mutation_p.S1188Y|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.S438Y	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	1227										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TTAGAAGACTCTCCGTATACA	0.299													32	157					3.99451e-17	4.78175e-17	1	0	A	177098636	A	A	177098636	3	1	55	1	0	0	0	0	1	0	0	0	17345	913	32	2	3794	2	WDR17	4	177098636	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	45868	177098636	14055640	128	10861											
LRP2BP	55805	broad.mit.edu	37	chr4	186294193	186294193	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtgcaccctgggactccAgattcccattgccacatgct	9	9	8	15	0	0	1	0	0	0	1	2	2	2	2	4	1	3	2	4	1	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:186294193A>G	uc003ixj.1	-	6	1432	c.620T>C	c.(619-621)CTG>CCG	p.L207P	LRP2BP_uc003ixk.1_Missense_Mutation_p.L181P|LRP2BP_uc011ckr.1_Missense_Mutation_p.L207P	NM_018409	NP_060879	Q9P2M1	LR2BP_HUMAN	LRP2 binding protein	207	Sel1-like 4.					cytoplasm	protein binding				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)		CTGGGACTCCAGATTCCCATT	0.473													23	85					0	0	0	0	G	186294193	G	G	186294193	3	3	55	1	0	0	0	0	1	0	0	0	9007	188	7	5	435	5	LRP2BP	4	186294193	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	9195557	186294193	4860083	129	10862											
TRIML1	339976	broad.mit.edu	37	chr4	189068081	189068081	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcagctacccgacaaccCggaaagatttgaccagtctg	13	6	9	13	2	1	2	0	1	1	1	1	4	1	3	3	1	4	2	3	1	3	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr4:189068081C>A	uc003izm.1	+	6	1077	c.962C>A	c.(961-963)CCG>CAG	p.P321Q	TRIML1_uc003izn.1_Missense_Mutation_p.P45Q	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	321	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CCCGACAACCCGGAAAGATTT	0.537													56	123					4.25531e-23	5.35451e-23	1	0	A	189068081	A	A	189068081	3	1	55	1	0	0	0	0	1	0	0	0	16617	652	23	3	984	3	TRIML1	4	189068081	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2773888	189068081	2086195	130	10863											
SLC9A3	6550	broad.mit.edu	37	chr5	524328	524328	+	Frame_Shift_Del	DEL	C	-	-																															cctggaagcccccgctctcgCcgtgcgcgccgccgggctcc																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:524328delC	uc003jbe.2	-	1	222	c.110delG	c.(109-111)GGCfs	p.G37fs	SLC9A3_uc011clx.1_Frame_Shift_Del_p.G37fs	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	37	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CCCGCTCTCGCCGTGCGCGCC	0.443													---	---	---								-	524328	-	-	524328	7	5	55	1	0	1	0	1	0	0	0	0	14777	739	26	0	2462	0	SLC9A3	5	524328	Frame_Shift_Del	DEL	C	TCGA-CN-5356-01A-01D-1434-08		524328	180390932	131	10864											
BRD9	65980	broad.mit.edu	37	chr5	884145	884145	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgctcctctgcggtactgtCcgtcaagctgcaggcattcc	5	11	11	14	2	2	0	1	0	1	0	5	0	5	0	3	2	5	5	3	2	2	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:884145C>T	uc003jbq.2	-	8	1041	c.874G>A	c.(874-876)GAC>AAC	p.D292N	BRD9_uc003jbl.2_Missense_Mutation_p.D176N|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Missense_Mutation_p.D239N|BRD9_uc003jbo.2_Missense_Mutation_p.D196N|BRD9_uc003jbp.2_5'Flank|BRD9_uc011cmc.1_RNA	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	292							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			GCGGTACTGTCCGTCAAGCTG	0.632													23	75					0	0	0	0	T	884145	T	T	884145	3	4	55	1	0	0	0	0	1	0	0	0	1512	855	30	2	955	2	BRD9	5	884145	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	359817	884145	180031115	132	10865											
ADAMTS16	170690	broad.mit.edu	37	chr5	5235236	5235236	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgtgctgctcagtgtgccGagcacaacagcagacgattc	9	8	11	13	3	1	1	1	0	0	1	3	3	2	1	2	0	6	4	2	0	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:5235236G>T	uc003jdl.2	+	13	2098	c.1960G>T	c.(1960-1962)GAG>TAG	p.E654*	ADAMTS16_uc003jdk.1_Nonsense_Mutation_p.E654*|ADAMTS16_uc010itk.1_RNA	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	654	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TCAGTGTGCCGAGCACAACAG	0.527													10	119					1.58986e-06	1.72294e-06	1	0	T	5235236	T	T	5235236	4	4	55	1	0	0	0	0	0	1	0	0	261	1059	37	3	2010	3	ADAMTS16	5	5235236	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4351091	5235236	175680024	133	10866											
FAM105B	90268	broad.mit.edu	37	chr5	14678802	14678802	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaacagaaccgagattaaGcgtagctcctgaaatggata	15	10	9	7	2	0	3	0	1	0	2	1	5	1	4	2	1	4	2	2	1	6	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:14678802G>T	uc003jfk.2	+	3	394	c.242G>T	c.(241-243)AGC>ATC	p.S81I		NM_138348	NP_612357	Q96BN8	F105B_HUMAN	hypothetical protein LOC90268	81										ovary(2)	2	Lung NSC(4;0.00696)					CCGAGATTAAGCGTAGCTCCT	0.358													9	36					2.17888e-05	2.32036e-05	1	0	T	14678802	T	T	14678802	3	4	55	1	0	0	0	0	1	0	0	0	5416	971	34	4	252	4	FAM105B	5	14678802	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	9443566	14678802	166236458	134	10867											
PRDM9	56979	broad.mit.edu	37	chr5	23527819	23527819	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggctttagcgataggtcaagCctctgctatcaccagaggac	10	9	11	11	1	3	1	2	0	1	1	3	3	3	2	2	3	3	2	2	3	4	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:23527819C>T	uc003jgo.2	+	11	2804	c.2622C>T	c.(2620-2622)AGC>AGT	p.S874S		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	874	C2H2-type 14.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATAGGTCAAGCCTCTGCTATC	0.522										HNSCC(3;0.000094)			33	110					0	0	0	0	T	23527819	T	T	23527819	2	4	55	1	0	0	0	0	0	0	0	1	12525	738	26	4		4	PRDM9	5	23527819	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	8849017	23527819	157387441	135	10868											
CDH9	1007	broad.mit.edu	37	chr5	26890582	26890582	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttatgccaaggagatgattCccggtcaagggctttcaaag	11	10	12	8	1	2	2	2	1	0	1	3	3	3	2	2	3	1	2	2	3	4	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:26890582C>A	uc003jgs.1	-	8	1514	c.1345G>T	c.(1345-1347)GAA>TAA	p.E449*	CDH9_uc011cnv.1_Nonsense_Mutation_p.E42*	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	449	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GGAGATGATTCCCGGTCAAGG	0.408													58	157					4.6707e-30	5.98433e-30	1	0	A	26890582	A	A	26890582	4	1	55	1	0	0	0	0	0	1	0	0	3132	864	30	2	1044	2	CDH9	5	26890582	Nonsense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3362763	26890582	154024678	136	10869											
RAI14	26064	broad.mit.edu	37	chr5	34823760	34823760	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagaaataccaagaagccCaagaagaaatcatgaaatta	21	7	7	6	0	1	5	1	2	0	4	1	6	1	5	2	0	2	0	2	0	9	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:34823760C>A	uc003jir.2	+	15	2009	c.1813C>A	c.(1813-1815)CAA>AAA	p.Q605K	RAI14_uc010iur.2_Missense_Mutation_p.Q576K|RAI14_uc011coj.1_Missense_Mutation_p.Q605K|RAI14_uc003jis.2_Missense_Mutation_p.Q608K|RAI14_uc003jit.2_Missense_Mutation_p.Q605K|RAI14_uc011cok.1_Missense_Mutation_p.Q597K	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	605	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					CCAAGAAGCCCAAGAAGAAAT	0.363													17	76					1.02788e-11	1.17883e-11	1	0	A	34823760	A	A	34823760	3	1	55	1	0	0	0	0	1	0	0	0	13073	595	21	4	1932	4	RAI14	5	34823760	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	7933178	34823760	146091500	137	10870											
DNAJC21	134218	broad.mit.edu	37	chr5	34954712	34954712	+	Frame_Shift_Del	DEL	C	-	-																															aatttccatctcggaataaaCtttttgaccatctaaaggcc																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:34954712delC	uc003jjc.2	+	12	1716	c.1489delC	c.(1489-1491)CTTfs	p.L497fs	DNAJC21_uc003jjb.2_Frame_Shift_Del_p.L542fs	NM_001012339	NP_001012339	Q5F1R6	DJC21_HUMAN	DnaJ homology subfamily A member 5 isoform 2	497	C2H2-type 2.				protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|skin(1)	2	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			TCGGAATAAACTTTTTGACCA	0.383													---	---	---								-	34954712	-	-	34954712	7	5	55	1	0	1	0	1	0	0	0	0	4662	565	20	0	1674	0	DNAJC21	5	34954712	Frame_Shift_Del	DEL	C	TCGA-CN-5356-01A-01D-1434-08	130952	34954712	145960548	138	10871											
C5orf39	389289	broad.mit.edu	37	chr5	43040127	43040127	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccaagcccgcttcacacAgccaagaaaatgttgctcca	13	7	6	15	1	1	1	1	0	0	1	3	1	3	1	4	0	3	3	4	0	4	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:43040127A>T	uc003jnf.2	-	1	321	c.22T>A	c.(22-24)TGT>AGT	p.C8S	C5orf39_uc010ivj.1_RNA|LOC153684_uc003jng.2_5'Flank|LOC153684_uc003jni.2_5'Flank	NM_001014279	NP_001014301	Q3ZCQ2	AX2R_HUMAN	annexin II receptor	8							receptor activity				0						CGCTTCACACAGCCAAGAAAA	0.547											OREG0016598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	117					0	0	0	0	T	43040127	T	T	43040127	3	4	55	1	0	0	0	0	1	0	0	0	2307	188	7	5	563	5	C5orf39	5	43040127	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	8085415	43040127	137875133	139	10872											
CCNB1	891	broad.mit.edu	37	chr5	68473452	68473452	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttagccaaggctgtggcaaaGgtgtaacttgtaaacttgag	12	11	12	6	0	0	1	0	1	0	0	0	1	0	1	1	3	3	4	1	3	6	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:68473452G>A	uc003jvm.2	+	9	1473	c.1296G>A	c.(1294-1296)AAG>AAA	p.K432K	CCNB1_uc010ixb.2_Silent_p.K395K	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	432					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		CTGTGGCAAAGGTGTAACTTG	0.383													22	140					0	0	0	0	A	68473452	A	A	68473452	2	1	55	1	0	0	0	0	0	0	0	1	2926	991	35	4		4	CCNB1	5	68473452	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	25433325	68473452	112441808	140	10873											
PDE8B	8622	broad.mit.edu	37	chr5	76607880	76607880	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacgcaggaccctattcaggTacgcctcctttactcagccc	8	9	8	16	2	2	0	2	0	0	0	3	2	3	1	4	2	3	2	4	2	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:76607880T>A	uc003kfa.2	+	2	444	c.399_splice	c.e2+2	p.Q133_splice	PDE8B_uc003kfb.2_Intron|PDE8B_uc003kfc.2_Splice_Site_p.Q133_splice|PDE8B_uc003kfd.2_Splice_Site_p.Q133_splice|PDE8B_uc003kfe.2_Splice_Site_p.Q133_splice	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1						cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		CCTATTCAGGTACGCCTCCTT	0.348													28	192					0	0	0	0	A	76607880	A	A	76607880	5	1	55	1	0	0	0	0	0	0	1	0	11708	1652	57	5	407	5	PDE8B	5	76607880	Splice_Site	SNP	T	TCGA-CN-5356-01A-01D-1434-08	8134428	76607880	104307380	141	10874											
CMYA5	202333	broad.mit.edu	37	chr5	79029872	79029872	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttagccatccagccgactttAaaaagggaggaaatcaagaa	17	7	9	8	1	1	1	1	0	0	1	2	4	2	3	3	2	2	0	3	2	7	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:79029872A>T	uc003kgc.2	+	2	5356	c.5284A>T	c.(5284-5286)AAA>TAA	p.K1762*		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1762						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGCCGACTTTAAAAAGGGAGG	0.413													16	95					0	0	0	0	T	79029872	T	T	79029872	4	4	55	1	0	0	0	0	0	1	0	0	3605	363	13	5	5290	5	CMYA5	5	79029872	Nonsense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	2421992	79029872	101885388	142	10875											
RASGRF2	5924	broad.mit.edu	37	chr5	80363998	80363998	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcgaaaggcttaaatcagaGgtatttcccagtcaatagat	15	11	8	7	1	2	2	2	0	0	2	4	3	3	2	1	2	0	2	1	2	6	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:80363998G>A	uc003kha.1	+	3	543	c.543G>A	c.(541-543)GAG>GAA	p.E181E	RASGRF2_uc011ctn.1_RNA|RASGRF2_uc003khb.1_5'Flank	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	181	Potential.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TTAAATCAGAGGTATTTCCCA	0.393													11	103					0	0	0	0	A	80363998	A	A	80363998	2	1	55	1	0	0	0	0	0	0	0	1	13138	1014	35	4		4	RASGRF2	5	80363998	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1334126	80363998	100551262	143	10876											
PCSK1	5122	broad.mit.edu	37	chr5	95764933	95764933	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttacacgatcatcatcagatAatctcttagtgatatgaaag	15	13	6	7	1	4	3	3	2	1	1	5	4	4	3	0	0	1	0	0	0	5	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:95764933A>G	uc003kls.1	-	2	475	c.269T>C	c.(268-270)TTA>TCA	p.L90S		NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	90					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATCATCAGATAATCTCTTAGT	0.333													20	144					0	0	0	0	G	95764933	G	G	95764933	3	3	55	1	0	0	0	0	1	0	0	0	11654	372	13	5	2044	5	PCSK1	5	95764933	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	15400935	95764933	85150327	144	10877											
SLCO6A1	133482	broad.mit.edu	37	chr5	101794169	101794169	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaaaaatgaagctgtttacGtttcctagcttttatccgtg	12	15	7	7	2	0	1	0	1	0	0	2	1	2	1	2	0	3	4	2	0	7	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:101794169G>A	uc003knn.2	-	6	1220	c.1048C>T	c.(1048-1050)CGT>TGT	p.R350C	SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Missense_Mutation_p.R350C|SLCO6A1_uc003knq.2_Missense_Mutation_p.R288C	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	350	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AGCTGTTTACGTTTCCTAGCT	0.294													24	133					0	0	0	0	A	101794169	A	A	101794169	3	1	55	1	0	0	0	0	1	0	0	0	14796	1145	40	1	1143	1	SLCO6A1	5	101794169	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	6029236	101794169	79121091	145	10878											
RAPGEF6	51735	broad.mit.edu	37	chr5	130815438	130815438	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagtcctaaaaagtaactCtttgaacactgtggaaataa	16	12	6	7	0	2	1	1	1	1	0	3	2	3	2	1	1	2	1	1	1	7	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:130815438C>A	uc003kvn.1	-	16	2055	c.1849G>T	c.(1849-1851)GAG>TAG	p.E617*	RAPGEF6_uc003kvp.1_Nonsense_Mutation_p.E667*|RAPGEF6_uc003kvo.1_Nonsense_Mutation_p.E617*|RAPGEF6_uc010jdi.1_Nonsense_Mutation_p.E617*|RAPGEF6_uc010jdj.1_Nonsense_Mutation_p.E617*|RAPGEF6_uc003kvq.2_Nonsense_Mutation_p.E334*|RAPGEF6_uc003kvr.2_Nonsense_Mutation_p.E617*|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Nonsense_Mutation_p.E617*	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	617					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		AAAAGTAACTCTTTGAACACT	0.328													20	112					1.01871e-10	1.15485e-10	1	0	A	130815438	A	A	130815438	4	1	55	1	0	0	0	0	0	1	0	0	13113	922	32	2	3494	2	RAPGEF6	5	130815438	Nonsense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	29021269	130815438	50099822	146	10879											
KIF3A	11127	broad.mit.edu	37	chr5	132069961	132069961	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagttataaacatcaagttgTttactctctggtccaaaaac	15	13	5	8	0	2	0	1	0	1	0	4	0	3	0	1	1	3	3	1	1	8	5	rs146249719	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:132069961T>A	uc003kxo.2	-	2	370	c.216A>T	c.(214-216)AAA>AAT	p.K72N	KIF3A_uc003kxn.2_Missense_Mutation_p.K31N|KIF3A_uc011cxf.1_Missense_Mutation_p.K72N|KIF3A_uc003kxp.2_Missense_Mutation_p.K72N	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	72	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CATCAAGTTGTTTACTCTCTG	0.318													75	142					0	0	0	0	A	132069961	A	A	132069961	3	1	55	1	0	0	0	0	1	0	0	0	8339	1722	60	5	1947	5	KIF3A	5	132069961	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	1254523	132069961	48845299	147	10880											
BRD8	10902	broad.mit.edu	37	chr5	137496708	137496708	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaattcagctgtgcttcGgatcagtccattttctatgt	8	16	8	9	1	3	1	2	1	1	0	5	2	4	2	1	1	2	2	1	1	2	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:137496708G>A	uc003lcf.1	-	18	2354	c.2299C>T	c.(2299-2301)CGA>TGA	p.R767*	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Nonsense_Mutation_p.R546*|BRD8_uc003lcg.2_Nonsense_Mutation_p.R840*|BRD8_uc003lci.2_Nonsense_Mutation_p.R770*|BRD8_uc003lch.2_Nonsense_Mutation_p.R661*|BRD8_uc011cym.1_Nonsense_Mutation_p.R751*|BRD8_uc010jer.1_Nonsense_Mutation_p.R736*|BRD8_uc011cyn.1_Nonsense_Mutation_p.R726*	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	767	Bromo 1.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCTGTGCTTCGGATCAGTCCA	0.408													15	106					0	0	0	0	A	137496708	A	A	137496708	4	1	55	1	0	0	0	0	0	1	0	0	1511	1124	39	1	1512	1	BRD8	5	137496708	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	5426747	137496708	43418552	148	10881											
PCDHA3	56145	broad.mit.edu	37	chr5	140182431	140182431	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctctgggcagcaacgtgaCgctgcaggtgttcgtgctgg	5	9	16	11	3	1	1	0	1	1	0	2	1	1	1	1	3	4	6	1	3	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:140182431C>T	uc003lhf.2	+	1	1649	c.1649C>T	c.(1648-1650)ACG>ATG	p.T550M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.T550M	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	550	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAACGTGACGCTGCAGGTG	0.687													26	108					0	0	0	0	T	140182431	T	T	140182431	3	4	55	1	0	0	0	0	1	0	0	0	11579	536	19	1	1651	1	PCDHA3	5	140182431	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2685723	140182431	40732829	149	10882											
PCDHA11	56138	broad.mit.edu	37	chr5	140250500	140250500	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggactcaggctacaacgcGtggctttcatatgaattgca	10	10	11	10	3	2	1	2	1	0	0	2	2	2	2	0	3	3	3	0	3	4	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:140250500G>T	uc003lia.2	+	1	2670	c.1812G>T	c.(1810-1812)GCG>GCT	p.A604A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.A604A	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	604	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTACAACGCGTGGCTTTCAT	0.672													13	67					2.62699e-14	3.06274e-14	1	0	T	140250500	T	T	140250500	2	4	55	1	0	0	0	0	0	0	0	1	11575	1132	40	3		3	PCDHA11	5	140250500	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	68069	140250500	40664760	150	10883											
PCDHB5	26167	broad.mit.edu	37	chr5	140516465	140516465	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agagactcaggcaccaacgcCcaggtcacctactcgctgct	10	6	9	16	2	2	1	2	0	0	1	3	2	2	1	3	2	3	3	3	2	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:140516465C>T	uc003liq.2	+	1	1666	c.1449C>T	c.(1447-1449)GCC>GCT	p.A483A		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	483	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACCAACGCCCAGGTCACCT	0.637													49	119					0	0	0	0	T	140516465	T	T	140516465	2	4	55	1	0	0	0	0	0	0	0	1	11599	610	22	4		4	PCDHB5	5	140516465	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	265965	140516465	40398795	151	10884											
PCDHGA2	56113	broad.mit.edu	37	chr5	140718644	140718644	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcagattcgctattctgtgCgggaagagatcgacagaggc	10	8	15	8	3	1	3	0	0	1	3	3	6	1	4	0	3	1	2	0	3	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:140718644C>T	uc003ljk.1	+	1	291	c.106C>T	c.(106-108)CGG>TGG	p.R36W	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.R36W	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	36	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATTCTGTGCGGGAAGAGAT	0.602											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	95					0	0	0	0	T	140718644	T	T	140718644	3	4	55	1	0	0	0	0	1	0	0	0	11608	759	27	1	108	1	PCDHGA2	5	140718644	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	202179	140718644	40196616	152	10885											
PCDHGA12	26025	broad.mit.edu	37	chr5	140811076	140811076	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagcccgagtaccgcgcgagCgttccggagaatctggcctt	7	7	13	14	6	1	1	0	0	1	1	2	4	2	1	4	2	3	2	4	2	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:140811076C>A	uc003lkt.1	+	1	919	c.750C>A	c.(748-750)AGC>AGA	p.S250R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.S250R	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	250	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGCGCGAGCGTTCCGGAGA	0.627													31	68					2.70662e-09	3.0128e-09	1	0	A	140811076	A	A	140811076	3	1	55	1	0	0	0	0	1	0	0	0	11607	767	27	3	752	3	PCDHGA12	5	140811076	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	92432	140811076	40104184	153	10886											
FGF1	2246	broad.mit.edu	37	chr5	141974899	141974899	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaaacaagattgctttctGgccatagtgagtccgaggac	12	9	12	8	1	1	3	0	1	1	2	2	6	2	4	2	2	2	1	2	2	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:141974899G>A	uc003lmm.2	-	4	504	c.424C>T	c.(424-426)CAG>TAG	p.Q142*	FGF1_uc011dbi.1_3'UTR|FGF1_uc003lmn.3_Nonsense_Mutation_p.Q142*|FGF1_uc003lmp.3_3'UTR|FGF1_uc003lmq.2_Nonsense_Mutation_p.Q142*|FGF1_uc010jgj.2_Nonsense_Mutation_p.Q141*|FGF1_uc003lmr.2_Nonsense_Mutation_p.Q142*|FGF1_uc003lms.3_Nonsense_Mutation_p.Q142*	NM_001144892	NP_001138364	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic) isoform 1	142	Heparin-binding.				angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding				0		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	ATTGCTTTCTGGCCATAGTGA	0.483													9	64					0	0	0	0	A	141974899	A	A	141974899	4	1	55	1	0	0	0	0	0	1	0	0	5870	1357	47	4	47	4	FGF1	5	141974899	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1163823	141974899	38940361	154	10887											
FAT2	2196	broad.mit.edu	37	chr5	150925209	150925209	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgctctcataatccatctCtgatacaatggttagggttc	10	14	7	10	0	2	1	1	1	2	0	6	1	3	1	1	2	2	3	1	2	4	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:150925209C>A	uc003lue.3	-	9	5492	c.5479G>T	c.(5479-5481)GAG>TAG	p.E1827*	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1827	Extracellular (Potential).|Cadherin 16.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TAATCCATCTCTGATACAATG	0.433													39	66					1.90571e-15	2.26475e-15	1	0	A	150925209	A	A	150925209	4	1	55	1	0	0	0	0	0	1	0	0	5722	922	32	2	7630	2	FAT2	5	150925209	Nonsense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	8950310	150925209	29990051	155	10888											
FAT2	2196	broad.mit.edu	37	chr5	150934053	150934053	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgccattaagaccctcaTccaggtctgaagccaccagc	10	8	7	16	0	3	2	1	1	2	1	4	2	4	2	5	1	3	0	5	1	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:150934053T>C	uc003lue.3	-	4	3828	c.3815A>G	c.(3814-3816)GAT>GGT	p.D1272G	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1272	Extracellular (Potential).|Cadherin 11.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGACCCTCATCCAGGTCTGA	0.557													39	187					0	0	0	0	C	150934053	C	C	150934053	3	2	55	1	0	0	0	0	1	0	0	0	5722	1435	50	5	9314	5	FAT2	5	150934053	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	8844	150934053	29981207	156	10889											
NSD1	64324	broad.mit.edu	37	chr5	176666861	176666861	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggggaccttggcctttctAaaaaggtatgttatttttgt	9	16	11	5	0	1	0	0	0	1	0	1	1	1	1	2	4	0	2	2	4	5	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:176666861A>T	uc003mfr.3	+	8	4435	c.4297A>T	c.(4297-4299)AAA>TAA	p.K1433*	NSD1_uc003mft.3_Nonsense_Mutation_p.K1164*|NSD1_uc003mfs.1_Nonsense_Mutation_p.K1330*|NSD1_uc011dfx.1_Nonsense_Mutation_p.K1081*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1433					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TGGCCTTTCTAAAAAGGTATG	0.313			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			36	46					0	0	0	0	T	176666861	T	T	176666861	4	4	55	1	0	0	0	0	0	1	0	0	10723	363	13	5	4323	5	NSD1	5	176666861	Nonsense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	25732808	176666861	4248399	157	10890											
GRM6	2916	broad.mit.edu	37	chr5	178410115	178410115	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagacagatccgacatgtcGcacttgagcacccctctggc	10	7	10	14	2	1	3	0	1	1	2	3	5	2	3	3	1	1	2	3	1	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:178410115G>A	uc003mjr.2	-	9	2411	c.2232C>T	c.(2230-2232)TGC>TGT	p.C744C	GRM6_uc003mjq.2_Silent_p.C147C	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	744	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CCGACATGTCGCACTTGAGCA	0.637													7	71					0	0	0	0	A	178410115	A	A	178410115	2	1	55	1	0	0	0	0	0	0	0	1	6840	1079	38	1		1	GRM6	5	178410115	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1743254	178410115	2505145	158	10891											
FLT4	2324	broad.mit.edu	37	chr5	180048550	180048550	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccagcctcaccctgcaccGacaggtacttcttgtggcag	7	8	11	15	1	2	0	1	0	1	0	2	1	2	0	4	3	3	3	4	3	1	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:180048550G>A	uc003mma.3	-	13	2091	c.2012C>T	c.(2011-2013)TCG>TTG	p.S671L	FLT4_uc003mlz.3_Missense_Mutation_p.S671L|FLT4_uc003mmb.1_Missense_Mutation_p.S204L|FLT4_uc011dgy.1_Missense_Mutation_p.S671L	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	671	Ig-like C2-type 6.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACCCTGCACCGACAGGTACTT	0.677									Congenital_Hereditary_Lymphedema				11	60					0	0	0	0	A	180048550	A	A	180048550	3	1	55	1	0	0	0	0	1	0	0	0	5976	1059	37	1	2159	1	FLT4	5	180048550	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1638435	180048550	866710	159	10892											
BTNL3	10917	broad.mit.edu	37	chr5	180432345	180432345	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccccagtggaggtgactCtggatccagagacggctcac	9	6	13	13	1	2	2	1	1	1	1	3	5	3	4	3	4	0	2	3	4	0	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr5:180432345C>A	uc003mmr.2	+	8	1002	c.874C>A	c.(874-876)CTG>ATG	p.L292M	BTNL3_uc010jlp.2_Missense_Mutation_p.L77M	NM_197975	NP_932079	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3 precursor	292	B30.2/SPRY.|Cytoplasmic (Potential).				lipid metabolic process	integral to membrane					0	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GGAGGTGACTCTGGATCCAGA	0.552													19	139					1.06647e-15	1.27047e-15	1	0	A	180432345	A	A	180432345	3	1	55	1	0	0	0	0	1	0	0	0	1571	912	32	2	904	2	BTNL3	5	180432345	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	383795	180432345	482915	160	10893											
NQO2	4835	broad.mit.edu	37	chr6	2997064	2997071	+	5'Flank	DEL	CCTTCCTT	-	-																															ggataaacaatgcctggtacCcttccttccttccttccttc																								rs72450506		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:2997064_2997071delCCTTCCTT	uc003mus.2	+						NQO2_uc003mup.1_Intron|NQO2_uc003mut.2_5'Flank	NM_000904	NP_000895	P16083	NQO2_HUMAN	NAD(P)H dehydrogenase, quinone 2							cytoplasm|nucleus	coenzyme binding|dihydronicotinamide riboside quinone reductase activity|electron carrier activity|metal ion binding|NADPH dehydrogenase (quinone) activity			ovary(1)	1	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Menadione(DB00170)|NADH(DB00157)	TGCCTGGTACccttccttccttccttcc	0.029													---	---	---								-	2997071	-	-	2997064	6	5	55	0	1	1	0	1	0	0	0	0	10666	638	22	0		0	NQO2	6	2997064	5'Flank	DEL	CCTTCCTT	TCGA-CN-5356-01A-01D-1434-08		2997064	168118003	161	10894											
DSP	1832	broad.mit.edu	37	chr6	7569464	7569464	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatcctgaaggacaacaacGagcgcagcaagtggtacgtg	13	6	13	9	3	0	1	0	1	0	0	1	3	1	2	1	2	5	4	1	2	6	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:7569464G>T	uc003mxp.1	+	12	1744	c.1465G>T	c.(1465-1467)GAG>TAG	p.E489*	DSP_uc003mxq.1_Nonsense_Mutation_p.E489*	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	489	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GGACAACAACGAGCGCAGCAA	0.527													83	91					1.13027e-35	1.47505e-35	1	0	T	7569464	T	T	7569464	4	4	55	1	0	0	0	0	0	1	0	0	4803	1059	37	3	1511	3	DSP	6	7569464	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4572400	7569464	163545603	162	10895											
HIVEP1	3096	broad.mit.edu	37	chr6	12125336	12125336	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcgggccaaagatgaaaatGgagctgtttgtgcaacagac	14	7	13	7	1	0	3	0	1	0	2	0	4	0	4	1	2	4	3	1	2	4	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:12125336G>A	uc003nac.2	+	4	5487	c.5308G>A	c.(5308-5310)GGA>AGA	p.G1770R	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1770					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGATGAAAATGGAGCTGTTTG	0.423													129	130					0	0	0	0	A	12125336	A	A	12125336	3	1	55	1	0	0	0	0	1	0	0	0	7225	1349	47	4	5318	4	HIVEP1	6	12125336	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4555872	12125336	158989731	163	10896											
PRL	5617	broad.mit.edu	37	chr6	22287700	22287700	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgtcgattttatgtgaatcCctgcgtaggcagtggagcag	8	13	13	7	2	0	1	0	1	0	0	2	3	1	2	1	2	2	3	1	2	3	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:22287700C>A	uc003ndp.2	-	5	1134	c.615G>T	c.(613-615)AGG>AGT	p.R205S	PRL_uc003ndo.2_Missense_Mutation_p.R206S|PRL_uc003ndq.2_Missense_Mutation_p.R205S	NM_000948	NP_000939	P01236	PRL_HUMAN	prolactin precursor	205					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding				0	Ovarian(93;0.163)					TATGTGAATCCCTGCGTAGGC	0.463													164	149					1.03592e-72	1.38499e-72	1	0	A	22287700	A	A	22287700	3	1	55	1	0	0	0	0	1	0	0	0	12590	622	22	4	72	4	PRL	6	22287700	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	10162364	22287700	148827367	164	10897											
HIST1H4B	8366	broad.mit.edu	37	chr6	26027337	26027337	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctcctcataaatcaaaccGgaaattcgcttaaccccacc	13	9	4	15	2	3	0	2	0	1	0	5	1	3	1	5	1	2	1	5	1	5	3	rs141516292		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:26027337G>A	uc003nfr.2	-	1	144	c.144C>T	c.(142-144)TCC>TCT	p.S48S		NM_003544	NP_003535	P62805	H4_HUMAN	histone cluster 1, H4b	48					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						AAATCAAACCGGAAATTCGCT	0.567													25	137					0	0	0	0	A	26027337	A	A	26027337	2	1	55	1	0	0	0	0	0	0	0	1	7205	1103	39	1		1	HIST1H4B	6	26027337	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	3739637	26027337	145087730	165	10898											
HIST1H4F	8361	broad.mit.edu	37	chr6	26240930	26240930	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgttgtctacgcgctcaagCgccagggacgcactctgtac	8	9	11	13	4	3	0	1	0	2	0	3	1	3	1	1	1	3	4	1	1	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:26240930C>T	uc003nhe.1	+	1	277	c.277C>T	c.(277-279)CGC>TGC	p.R93C		NM_003540	NP_003531	P62805	H4_HUMAN	histone cluster 1, H4f	93					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				CGCGCTCAAGCGCCAGGGACG	0.547													7	131					0	0	0	0	T	26240930	T	T	26240930	3	4	55	1	0	0	0	0	1	0	0	0	7209	768	27	1	279	1	HIST1H4F	6	26240930	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	213593	26240930	144874137	166	10899											
OR2W1	26692	broad.mit.edu	37	chr6	29012622	29012622	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacagccaggagaaggcactCaactgagcccaaccacatgt	15	4	9	13	0	1	2	1	1	0	1	1	3	1	2	3	2	5	1	3	2	4	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:29012622C>G	uc003nlw.2	-	1	331	c.331G>C	c.(331-333)GAG>CAG	p.E111Q		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						AGAAGGCACTCAACTGAGCCC	0.433													21	123					0	0	0	0	G	29012622	G	G	29012622	3	3	55	1	0	0	0	0	1	0	0	0	11086	835	29	2	635	2	OR2W1	6	29012622	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2771692	29012622	142102445	167	10900											
OR2J2	26707	broad.mit.edu	37	chr6	29141990	29141990	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgtttatcatgtgttgacaCccatgcaaatgagctgaccc	10	11	9	11	1	1	3	1	3	0	0	1	3	1	3	2	0	2	4	2	0	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:29141990C>A	uc011dlm.1	+	1	680	c.578C>A	c.(577-579)ACC>AAC	p.T193N		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGTGTTGACACCCATGCAAAT	0.473													41	339					1.49673e-21	1.86902e-21	1	0	A	29141990	A	A	29141990	3	1	55	1	0	0	0	0	1	0	0	0	11057	507	18	4	580	4	OR2J2	6	29141990	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	129368	29141990	141973077	168	10901											
MOG	4340	broad.mit.edu	37	chr6	29638476	29638476	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgtttctttttgttttcAgggcaattccttgaagagct	7	20	8	6	0	2	2	1	1	1	1	3	2	3	2	1	1	1	4	1	1	2	8			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:29638476A>G	uc003nnf.2	+	7	888	c.710_splice	c.e7-2	p.G237_splice	MOG_uc003nmy.1_Splice_Site_p.G237_splice|MOG_uc003nmz.2_Splice_Site|MOG_uc011dlt.1_Splice_Site_p.G167_splice|MOG_uc003nna.2_Splice_Site_p.G121_splice|MOG_uc011dlu.1_Splice_Site_p.G98_splice|MOG_uc011dlv.1_Splice_Site_p.G82_splice|MOG_uc003nnd.2_Splice_Site|MOG_uc003nne.2_Splice_Site_p.G237_splice|MOG_uc003nng.2_Splice_Site_p.G214_splice|MOG_uc003nnh.2_Splice_Site_p.G198_splice|MOG_uc003nni.2_Splice_Site_p.G214_splice|MOG_uc003nnj.2_Splice_Site_p.G198_splice|MOG_uc003nnk.2_Intron	NM_206809	NP_996532	Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein isoform						cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)	1						TTTTGTTTTCAGGGCAATTCC	0.438													24	30					0	0	0	0	G	29638476	G	G	29638476	5	3	55	1	0	0	0	0	0	0	1	0	9746	202	7	5	870	5	MOG	6	29638476	Splice_Site	SNP	A	TCGA-CN-5356-01A-01D-1434-08	496486	29638476	141476591	169	10902											
TRIM26	7726	broad.mit.edu	37	chr6	30166209	30166209	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaacagcctcacttaccagCgcggccaggatatcagcttc	11	7	9	14	2	2	0	2	0	0	0	3	2	2	1	3	2	5	1	3	2	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:30166209C>T	uc003npr.2	-	4	740	c.531G>A	c.(529-531)GCG>GCA	p.A177A	TRIM26_uc003nps.2_Silent_p.A177A|TRIM26_uc010jry.2_5'UTR|TRIM26_uc003npt.2_Silent_p.A177A	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	177							DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CACTTACCAGCGCGGCCAGGA	0.577													17	202					0	0	0	0	T	30166209	T	T	30166209	2	4	55	1	0	0	0	0	0	0	0	1	16567	755	27	1		1	TRIM26	6	30166209	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	527733	30166209	140948858	170	10903											
NOTCH4	4855	broad.mit.edu	37	chr6	32180994	32180994	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaggcaggagaaggtgccagGcctgttcacacaggtacccc	10	5	14	12	0	1	1	1	0	0	1	1	3	1	1	4	5	2	3	4	5	2	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:32180994G>A	uc003obb.2	-	15	2495	c.2356C>T	c.(2356-2358)CCT>TCT	p.P786S	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	786	EGF-like 20.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						AAGGTGCCAGGCCTGTTCACA	0.627													72	79					0	0	0	0	A	32180994	A	A	32180994	3	1	55	1	0	0	0	0	1	0	0	0	10605	1203	42	4	3719	4	NOTCH4	6	32180994	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2014785	32180994	138934073	171	10904											
RPL10A	4736	broad.mit.edu	37	chr6	35438521	35438521	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgggcaagccccagcgcctAtattaaggcacatttgaata	13	9	9	10	1	0	1	0	1	0	0	0	1	0	1	3	2	2	2	3	2	6	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:35438521A>G	uc003okp.1	+	6	682	c.648A>G	c.(646-648)CTA>CTG	p.L216L	RPL10A_uc003okq.1_Silent_p.L132L|RPL10A_uc003okr.1_Silent_p.L132L|RPL10A_uc003oks.1_Silent_p.L132L	NM_007104	NP_009035	P62906	RL10A_HUMAN	ribosomal protein L10a	216					anatomical structure morphogenesis|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	RNA binding|structural constituent of ribosome			ovary(1)	1						CCCAGCGCCTATATTAAGGCA	0.493													64	66					0	0	0	0	G	35438521	G	G	35438521	2	3	55	1	0	0	0	0	0	0	0	1	13620	436	16	5		5	RPL10A	6	35438521	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	3257527	35438521	135676546	172	10905											
DAAM2	23500	broad.mit.edu	37	chr6	39838206	39838206	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctccggcaacatgaaaatGccatcctggacaagtaagtt	14	8	9	10	1	0	1	0	1	0	0	2	2	2	2	3	2	3	4	3	2	5	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:39838206G>T	uc003oow.2	+	8	1120	c.964G>T	c.(964-966)GCC>TCC	p.A322S	DAAM2_uc010jxc.2_Missense_Mutation_p.A322S|DAAM2_uc003oox.2_Missense_Mutation_p.A322S	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	322	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					ACATGAAAATGCCATCCTGGA	0.517													7	10					2.0095e-06	2.1634e-06	1	0	T	39838206	T	T	39838206	3	4	55	1	0	0	0	0	1	0	0	0	4233	1319	46	4	990	4	DAAM2	6	39838206	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4399685	39838206	131276861	173	10906											
DAAM2	23500	broad.mit.edu	37	chr6	39855276	39855276	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcagaaagagctgggctcCactgaagacatctacctggc	11	8	11	11	0	1	4	0	1	1	3	2	4	2	4	2	2	3	3	2	2	3	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:39855276C>T	uc003oow.2	+	16	2124	c.1968C>T	c.(1966-1968)TCC>TCT	p.S656S	DAAM2_uc003oox.2_Silent_p.S656S|uc003ooz.1_5'Flank	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	656	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					AGCTGGGCTCCACTGAAGACA	0.542													10	50					0	0	0	0	T	39855276	T	T	39855276	2	4	55	1	0	0	0	0	0	0	0	1	4233	581	21	4		4	DAAM2	6	39855276	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	17070	39855276	131259791	174	10907											
SUPT3H	8464	broad.mit.edu	37	chr6	44922282	44922282	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taagatttccattgcgacaaCattgggttttatctccatac	11	15	6	9	1	1	1	0	0	1	1	3	2	2	1	2	1	3	1	2	1	4	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:44922282C>T	uc003oxo.2	-	10	994	c.676G>A	c.(676-678)GTT>ATT	p.V226I	SUPT3H_uc003oxn.1_Missense_Mutation_p.V215I|SUPT3H_uc011dvv.1_Missense_Mutation_p.V63I|SUPT3H_uc003oxp.2_Missense_Mutation_p.V215I|SUPT3H_uc011dvw.1_Missense_Mutation_p.V129I	NM_181356	NP_852001	O75486	SUPT3_HUMAN	suppressor of Ty 3 homolog isoform 2	297					histone deubiquitination|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	STAGA complex|transcription factor TFTC complex	DNA binding|transcription coactivator activity			ovary(2)|breast(1)	3						ATTGCGACAACATTGGGTTTT	0.383													22	265					0	0	0	0	T	44922282	T	T	44922282	3	4	55	1	0	0	0	0	1	0	0	0	15463	478	17	4	326	4	SUPT3H	6	44922282	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	5067006	44922282	126192785	175	10908											
MEP1A	4224	broad.mit.edu	37	chr6	46761196	46761196	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctttttgcccacatagcaGctgtaccggtaagtcgagtc	8	12	10	11	2	0	0	0	0	0	0	2	1	0	0	2	1	5	5	2	1	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:46761196G>T	uc010jzh.1	+	1	103	c.61G>T	c.(61-63)GCT>TCT	p.A21S	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Missense_Mutation_p.A21S|MEP1A_uc011dwi.1_5'UTR	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	21					digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			CCACATAGCAGCTGTACCGGT	0.343													129	389					2.10208e-94	2.81805e-94	1	0	T	46761196	T	T	46761196	3	4	55	1	0	0	0	0	1	0	0	0	9528	971	34	4	63	4	MEP1A	6	46761196	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1838914	46761196	124353871	176	10909											
GPR111	222611	broad.mit.edu	37	chr6	47650333	47650333	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagatccctggccttccacAttatcttctccctgctcaat	8	13	4	16	0	3	1	1	0	2	1	6	1	5	1	4	1	1	1	4	1	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:47650333A>T	uc010jzj.1	+	6	2039	c.2038A>T	c.(2038-2040)ATT>TTT	p.I680F	GPR111_uc010jzk.1_Missense_Mutation_p.I612F|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	680	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GGCCTTCCACATTATCTTCTC	0.483													52	85					0	0	0	0	T	47650333	T	T	47650333	3	4	55	1	0	0	0	0	1	0	0	0	6666	217	8	5	1852	5	GPR111	6	47650333	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	889137	47650333	123464734	177	10910											
EYS	346007	broad.mit.edu	37	chr6	66204988	66204988	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacgaaagatgtttcagaaaCattcatcaaatttatttctg	16	14	5	6	1	4	2	3	0	1	2	4	3	4	2	0	0	2	1	0	0	5	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:66204988C>T	uc011dxu.1	-	4	854	c.316G>A	c.(316-318)GTT>ATT	p.V106I	EYS_uc003peq.2_Missense_Mutation_p.V106I|EYS_uc003per.1_Missense_Mutation_p.V106I|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	106					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						GTTTCAGAAACATTCATCAAA	0.363													38	150					0	0	0	0	T	66204988	T	T	66204988	3	4	55	1	0	0	0	0	1	0	0	0	5357	478	17	4	9240	4	EYS	6	66204988	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	18554655	66204988	104910079	178	10911											
AIM1	202	broad.mit.edu	37	chr6	106969128	106969128	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctggattcacgaagcaacCtacacttgccagaaactaaa	16	8	6	11	1	2	1	1	0	1	1	2	3	2	2	2	1	5	1	2	1	6	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:106969128C>G	uc003prh.2	+	2	3308	c.2821C>G	c.(2821-2823)CTA>GTA	p.L941V		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	941							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		ACGAAGCAACCTACACTTGCC	0.363													45	61					0	0	0	0	G	106969128	G	G	106969128	3	3	55	1	0	0	0	0	1	0	0	0	430	680	24	4	2827	4	AIM1	6	106969128	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	40764140	106969128	64145939	179	10912											
KIAA1919	91749	broad.mit.edu	37	chr6	111588223	111588223	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctgaagtctataatcaataCccatcaaatgcactggtgtt	13	12	7	9	0	3	1	2	1	1	0	3	1	3	1	1	1	2	3	1	1	6	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:111588223C>G	uc003puv.3	+	4	1880	c.1458C>G	c.(1456-1458)TAC>TAG	p.Y486*		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	486	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		ATAATCAATACCCATCAAATG	0.403													29	83					0	0	0	0	G	111588223	G	G	111588223	4	3	55	1	0	0	0	0	0	1	0	0	8301	518	18	4	1472	4	KIAA1919	6	111588223	Nonsense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	4619095	111588223	59526844	180	10913											
SYNE1	23345	broad.mit.edu	37	chr6	152702405	152702405	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccgtgtgcatgagctcacaCccactggcagttgtgttctg	6	12	11	12	1	2	1	1	1	1	0	3	1	3	1	2	1	2	5	2	1	0	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:152702405C>G	uc010kiw.2	-	56	9347	c.8745G>C	c.(8743-8745)GGG>GGC	p.G2915G	SYNE1_uc003qot.3_Silent_p.G2922G|SYNE1_uc003qou.3_Silent_p.G2915G|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_5'UTR|SYNE1_uc010kjb.1_Silent_p.G2898G	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2915	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGAGCTCACACCCACTGGCAG	0.547										HNSCC(10;0.0054)			100	148					0	0	0	0	G	152702405	G	G	152702405	2	3	55	1	0	0	0	0	0	0	0	1	15511	494	18	4		4	SYNE1	6	152702405	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	41114182	152702405	18412662	181	10914											
CNKSR3	154043	broad.mit.edu	37	chr6	154727662	154727662	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctgcttcctcggatgtaGtccgcaccccggaccagatg	7	8	10	16	3	0	1	0	0	0	1	3	3	2	3	6	2	1	3	6	2	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:154727662G>C	uc003qpy.2	-	13	1999	c.1494C>G	c.(1492-1494)GAC>GAG	p.D498E		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	498	DUF1170.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		CTCGGATGTAGTCCGCACCCC	0.567													44	94					0	0	0	0	C	154727662	C	C	154727662	3	2	55	1	0	0	0	0	1	0	0	0	3623	1020	36	4	177	4	CNKSR3	6	154727662	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2025257	154727662	16387405	182	10915											
TCP10L2	401285	broad.mit.edu	37	chr6	167590618	167590618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctaaccacttagctcctcCaaaggtgacccttcgtgctt	9	12	6	14	1	1	1	0	1	1	0	4	1	3	1	4	1	3	2	4	1	3	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:167590618C>T	uc010kkp.2	+	4	625	c.494C>T	c.(493-495)CCA>CTA	p.P165L		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	165											0						TTAGCTCCTCCAAAGGTGACC	0.522													24	58					0	0	0	0	T	167590618	T	T	167590618	3	4	55	1	0	0	0	0	1	0	0	0	15778	594	21	4	504	4	TCP10L2	6	167590618	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	12862956	167590618	3524449	183	10916											
TCP10	6953	broad.mit.edu	37	chr6	167791447	167791447	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagcacgaagggtcacctttGgaggagctaagtggttagat	12	9	14	6	1	1	1	1	0	0	1	1	4	1	3	1	4	2	3	1	4	4	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr6:167791447G>A	uc003qvv.1	-	4	625	c.413C>T	c.(412-414)CCA>CTA	p.P138L	TCP10_uc003qvu.2_Missense_Mutation_p.P138L|TCP10_uc003qvw.2_Missense_Mutation_p.P114L	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10	165						cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		GGTCACCTTTGGAGGAGCTAA	0.522													42	237					0	0	0	0	A	167791447	A	A	167791447	3	1	55	1	0	0	0	0	1	0	0	0	15776	1348	47	4	587	4	TCP10	6	167791447	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	200829	167791447	3323620	184	10917											
SUN1	23353	broad.mit.edu	37	chr7	893209	893209	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gatggaaggcggcgctgccgGgccgtcagcttcggtcagag	6	6	18	11	5	2	1	2	0	0	1	3	3	2	2	2	5	2	2	2	5	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:893209G>T	uc011jvp.1	+	11	1296	c.1217G>T	c.(1216-1218)GGG>GTG	p.G406V	GET4_uc003sjj.1_RNA|SUN1_uc003sjf.2_Missense_Mutation_p.G323V|SUN1_uc011jvq.1_Missense_Mutation_p.G303V|SUN1_uc003sjg.2_Missense_Mutation_p.G311V|SUN1_uc011jvr.1_Missense_Mutation_p.G215V|SUN1_uc003sji.2_Missense_Mutation_p.G244V|SUN1_uc003sjk.2_Missense_Mutation_p.G45V	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	433	Perinuclear space.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GGCGCTGCCGGGCCGTCAGCT	0.647													18	58					7.41877e-09	8.20233e-09	1	0	T	893209	T	T	893209	3	4	55	1	0	0	0	0	1	0	0	0	15457	1232	43	4	1438	4	SUN1	7	893209	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08		893209	158245454	185	10918											
ABCB5	340273	broad.mit.edu	37	chr7	20793095	20793095	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaattttattgttggatgAggccacttcagccctcgata	11	13	8	9	1	1	1	1	1	0	0	2	3	1	2	2	2	1	1	2	2	4	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:20793095A>G	uc003suw.3	+	18	2753	c.2207A>G	c.(2206-2208)GAG>GGG	p.E736G	ABCB5_uc010kuh.2_Missense_Mutation_p.E1181G	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	736	Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TTGTTGGATGAGGCCACTTCA	0.398													23	100					0	0	0	0	G	20793095	G	G	20793095	3	3	55	1	0	0	0	0	1	0	0	0	44	304	11	5	3685	5	ABCB5	7	20793095	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	19899886	20793095	138345568	186	10919											
JAZF1	221895	broad.mit.edu	37	chr7	27872583	27872583	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcttagcgtgatactttaTgccattcacattctgtggag	9	16	8	8	1	3	1	1	1	2	0	3	2	3	2	1	1	3	0	1	1	3	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:27872583T>C	uc003szn.2	-	5	809	c.568A>G	c.(568-570)ATA>GTA	p.I190V	JAZF1_uc003szm.2_Missense_Mutation_p.I126V	NM_175061	NP_778231	Q86VZ6	JAZF1_HUMAN	JAZF zinc finger 1	190	C2H2-type 2.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcriptional repressor complex	nucleic acid binding|transcription corepressor activity|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131						TGATACTTTATGCCATTCACA	0.438			T	SUZ12	endometrial stromal tumours								18	32					0	0	0	0	C	27872583	C	C	27872583	3	2	55	1	0	0	0	0	1	0	0	0	7985	1464	51	5	167	5	JAZF1	7	27872583	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	7079488	27872583	131266080	187	10920											
NEUROD6	63974	broad.mit.edu	37	chr7	31378427	31378427	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcagatctggtctcttgccGattctcagaatttcagaaag	11	12	9	9	1	4	3	2	0	3	3	6	4	4	3	1	1	2	1	1	1	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:31378427G>A	uc003tch.2	-	2	809	c.456C>T	c.(454-456)ATC>ATT	p.I152I		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	152					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						GTCTCTTGCCGATTCTCAGAA	0.458													35	110					0	0	0	0	A	31378427	A	A	31378427	2	1	55	1	0	0	0	0	0	0	0	1	10405	1048	37	1		1	NEUROD6	7	31378427	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	3505844	31378427	127760236	188	10921											
BBS9	27241	broad.mit.edu	37	chr7	33388738	33388738	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attatcagtctacgtgcaacCaccattagaattgacttgtg	12	13	7	9	1	2	2	1	1	1	1	2	2	2	2	2	0	3	1	2	0	5	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:33388738C>G	uc003tdn.1	+	13	1901	c.1388C>G	c.(1387-1389)CCA>CGA	p.P463R	BBS9_uc003tdo.1_Missense_Mutation_p.P463R|BBS9_uc003tdp.1_Missense_Mutation_p.P463R|BBS9_uc003tdq.1_Missense_Mutation_p.P463R|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_5'UTR|BBS9_uc003tds.1_5'Flank|BBS9_uc011kao.1_Missense_Mutation_p.P341R	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	463					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TACGTGCAACCACCATTAGAA	0.318									Bardet-Biedl_syndrome				22	134					0	0	0	0	G	33388738	G	G	33388738	3	3	55	1	0	0	0	0	1	0	0	0	1344	594	21	4	1434	4	BBS9	7	33388738	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2010311	33388738	125749925	189	10922											
PCLO	27445	broad.mit.edu	37	chr7	82538228	82538228	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actgagtggtctagagtggaCcaatctttccggcagttttc	8	13	11	9	1	2	2	0	1	2	1	4	3	3	3	2	3	0	2	2	3	2	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:82538228C>A	uc003uhx.2	-	8	13691	c.13402G>T	c.(13402-13404)GTC>TTC	p.V4468F	PCLO_uc003uhv.2_Missense_Mutation_p.V4468F	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4399					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTAGAGTGGACCAATCTTTCC	0.413													35	120					4.3181e-19	5.28484e-19	1	0	A	82538228	A	A	82538228	3	1	55	1	0	0	0	0	1	0	0	0	11637	507	18	4	2115	4	PCLO	7	82538228	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	49149490	82538228	76600435	190	10923											
SEMA3A	10371	broad.mit.edu	37	chr7	83610727	83610727	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aacactcagcacacgctttcCcgtaaatatcacaccggtgt	12	9	6	14	3	2	0	2	0	0	0	3	0	3	0	2	1	2	3	2	1	4	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:83610727C>G	uc003uhz.2	-	14	1877	c.1562G>C	c.(1561-1563)GGG>GCG	p.G521A		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	521					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ACACGCTTTCCCGTAAATATC	0.483													16	30					0	0	0	0	G	83610727	G	G	83610727	3	3	55	1	0	0	0	0	1	0	0	0	14089	623	22	4	769	4	SEMA3A	7	83610727	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	1072499	83610727	75527936	191	10924											
GRM3	2913	broad.mit.edu	37	chr7	86394654	86394654	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcgaatcaatgaagaccgaGggattcaacgcctggaagcc	13	5	13	10	3	2	2	2	1	0	1	2	6	2	4	3	3	2	0	3	3	5	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:86394654G>A	uc003uid.2	+	2	1292	c.193G>A	c.(193-195)GGG>AGG	p.G65R	GRM3_uc010lef.2_Missense_Mutation_p.G63R|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	65	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGAAGACCGAGGGATTCAACG	0.418													40	142					0	0	0	0	A	86394654	A	A	86394654	3	1	55	1	0	0	0	0	1	0	0	0	6837	1000	35	4	195	4	GRM3	7	86394654	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2783927	86394654	72744009	192	10925											
DMTF1	9988	broad.mit.edu	37	chr7	86817562	86817562	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcttggaagataatacagcCatctcttctagccccatggc	10	10	8	13	1	2	1	0	0	2	1	3	2	2	2	3	2	3	1	3	2	4	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:86817562C>T	uc003uih.2	+	13	1682	c.1356C>T	c.(1354-1356)GCC>GCT	p.A452A	DMTF1_uc003uii.2_Silent_p.A186A|DMTF1_uc003uij.2_Silent_p.A186A|DMTF1_uc011khb.1_Silent_p.A364A|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Silent_p.A452A|DMTF1_uc003uin.2_Silent_p.A186A	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	452	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					ATAATACAGCCATCTCTTCTA	0.418													86	288					0	0	0	0	T	86817562	T	T	86817562	2	4	55	1	0	0	0	0	0	0	0	1	4614	581	21	4		4	DMTF1	7	86817562	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	422908	86817562	72321101	193	10926											
AKAP9	10142	broad.mit.edu	37	chr7	91631698	91631698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgtgggaaaaagaaataGaaatacttatagaggaaaat	20	9	10	2	0	0	3	0	0	0	3	0	5	0	5	0	2	1	0	0	2	10	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:91631698G>A	uc003ulg.2	+	8	2692	c.2467G>A	c.(2467-2469)GAA>AAA	p.E823K	AKAP9_uc003ule.2_Missense_Mutation_p.E835K|AKAP9_uc003ulf.2_Missense_Mutation_p.E823K|AKAP9_uc003uli.2_Missense_Mutation_p.E448K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	835	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAAGAAATAGAAATACTTAT	0.323			T	BRAF	papillary thyroid								46	137					0	0	0	0	A	91631698	A	A	91631698	3	1	55	1	0	0	0	0	1	0	0	0	459	943	33	2	2497	2	AKAP9	7	91631698	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4814136	91631698	67506965	194	10927											
VGF	7425	broad.mit.edu	37	chr7	100806374	100806374	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcctcctcctgcgcgcgcCgcgcctgggcctcccggccg	0	5	13	23	8	0	0	0	0	0	0	3	0	3	0	9	2	1	0	9	2	0	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:100806374C>G	uc003uxx.3	-	2	1969	c.1751G>C	c.(1750-1752)CGG>CCG	p.R584P		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	584					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					CTGCGCGCGCCGCGCCTGGGC	0.746													7	35					0	0	0	0	G	100806374	G	G	100806374	3	3	55	1	0	0	0	0	1	0	0	0	17225	652	23	3	100	3	VGF	7	100806374	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	9174676	100806374	58332289	195	10928											
FBXL13	222235	broad.mit.edu	37	chr7	102553619	102553619	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagcctttgtctgtgaaccGtctgcaataagccaaactaa	13	11	7	10	1	2	1	0	1	2	0	2	1	2	1	3	0	5	1	3	0	6	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:102553619G>A	uc003vaq.2	-	11	1349	c.922C>T	c.(922-924)CGG>TGG	p.R308W	FBXL13_uc010liq.1_Missense_Mutation_p.R123W|FBXL13_uc010lir.1_Missense_Mutation_p.R308W|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.R308W|LRRC17_uc003vat.2_Intron|LRRC17_uc003vau.2_Intron	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	308	LRR 4.										0						TCTGTGAACCGTCTGCAATAA	0.438													19	102					0	0	0	0	A	102553619	A	A	102553619	3	1	55	1	0	0	0	0	1	0	0	0	5741	1144	40	1	1325	1	FBXL13	7	102553619	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1747245	102553619	56585044	196	10929											
RELN	5649	broad.mit.edu	37	chr7	103126772	103126772	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctatgactccaccttgaatGgtctcccagtttgcctcggt	6	13	8	14	1	1	2	0	2	1	0	4	2	2	2	5	2	1	1	5	2	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:103126772G>T	uc003vca.2	-	61	10015	c.9855C>A	c.(9853-9855)ACC>ACA	p.T3285T	RELN_uc010liz.2_Silent_p.T3285T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3285					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CACCTTGAATGGTCTCCCAGT	0.502													42	136					1.23103e-26	1.56908e-26	1	0	T	103126772	T	T	103126772	2	4	55	1	0	0	0	0	0	0	0	1	13285	1335	47	4		4	RELN	7	103126772	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	573153	103126772	56011891	197	10930											
RELN	5649	broad.mit.edu	37	chr7	103180756	103180756	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctccagggcaatgtacctgCccacattgctggaattgctg	8	11	10	12	0	1	0	0	0	1	0	2	1	1	1	3	2	4	4	3	2	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:103180756C>T	uc003vca.2	-	44	6978	c.6818G>A	c.(6817-6819)GGC>GAC	p.G2273D	RELN_uc010liz.2_Missense_Mutation_p.G2273D	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2273					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AATGTACCTGCCCACATTGCT	0.552													37	115					0	0	0	0	T	103180756	T	T	103180756	3	4	55	1	0	0	0	0	1	0	0	0	13285	739	26	4	3652	4	RELN	7	103180756	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	53984	103180756	55957907	198	10931											
EXOC4	60412	broad.mit.edu	37	chr7	133749194	133749194	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggaactgaccacccagaaCacgaggctgcagaggctcaa	13	3	13	12	1	1	3	1	1	0	2	1	5	1	4	2	4	3	3	2	4	3	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:133749194C>A	uc003vrk.2	+	18	2873	c.2838C>A	c.(2836-2838)AAC>AAA	p.N946K	EXOC4_uc011kpo.1_Missense_Mutation_p.N845K|EXOC4_uc003vrl.2_Missense_Mutation_p.N556K|EXOC4_uc011kpp.1_Missense_Mutation_p.N478K|EXOC4_uc011kpq.1_Missense_Mutation_p.N234K	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	946					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				CCACCCAGAACACGAGGCTGC	0.582													23	96					0.00047179	0.000493873	1	0	A	133749194	A	A	133749194	3	1	55	1	0	0	0	0	1	0	0	0	5330	477	17	4	2917	4	EXOC4	7	133749194	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	30568438	133749194	25389469	199	10932											
C7orf55	154791	broad.mit.edu	37	chr7	139030441	139030441	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagcctggagggaagggctgGgagccatgaacatggagaat	12	5	17	7	0	0	2	0	1	0	1	0	6	0	5	2	5	3	1	2	5	3	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:139030441G>A	uc003vuw.3	+	2	567	c.333G>A	c.(331-333)TGG>TGA	p.W111*	LUC7L2_uc011kqs.1_Intron|LUC7L2_uc011kqt.1_Intron	NM_197964	NP_932068	Q96HJ9	CG055_HUMAN	formation of mitochondrial complexes 1 homolog	111											0						GGAAGGGCTGGGAGCCATGAA	0.438													7	56					0	0	0	0	A	139030441	A	A	139030441	4	1	55	1	0	0	0	0	0	1	0	0	2414	1241	43	4	339	4	C7orf55	7	139030441	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	5281247	139030441	20108222	200	10933											
MGAM	8972	broad.mit.edu	37	chr7	141754696	141754696	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaaattcgccggaagagtaCaggcactataatgtgagtgg	13	9	13	6	2	0	3	0	2	0	1	1	4	0	4	1	3	1	2	1	3	5	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:141754696C>A	uc003vwy.2	+	27	3356	c.3302C>A	c.(3301-3303)ACA>AAA	p.T1101K		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1101	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CGGAAGAGTACAGGCACTATA	0.488													29	96					2.42023e-17	2.91138e-17	1	0	A	141754696	A	A	141754696	3	1	55	1	0	0	0	0	1	0	0	0	9594	478	17	4	3404	4	MGAM	7	141754696	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2724255	141754696	17383967	201	10934											
TAS2R39	259285	broad.mit.edu	37	chr7	142880918	142880918	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggctcagtttcttctactTtgtgaagattgccaatttct	7	18	7	9	0	4	2	1	1	3	1	4	2	4	2	1	1	2	2	1	1	3	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:142880918T>A	uc011ksw.1	+	1	407	c.407T>A	c.(406-408)TTT>TAT	p.F136Y		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	136	Helical; Name=3; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					TTCTTCTACTTTGTGAAGATT	0.388													63	195					0	0	0	0	A	142880918	A	A	142880918	3	1	55	1	0	0	0	0	1	0	0	0	15642	1841	64	5	409	5	TAS2R39	7	142880918	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	1126222	142880918	16257745	202	10935											
FAM115A	9747	broad.mit.edu	37	chr7	143573297	143573297	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaacttgaccagcttttcTgtcatggtttcattgtaggc	8	16	9	8	0	3	2	2	2	1	0	3	2	3	2	1	2	2	3	1	2	2	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:143573297T>C	uc003wdo.1	-	2	538	c.405A>G	c.(403-405)ACA>ACG	p.T135T	FAM115A_uc011ktu.1_Intron|FAM115A_uc003wdp.1_Silent_p.T135T	NM_014719	NP_055534	Q9Y4C2	F115A_HUMAN	hypothetical protein LOC9747	135											0	Melanoma(164;0.0903)					CCAGCTTTTCTGTCATGGTTT	0.507													62	128					0	0	0	0	C	143573297	C	C	143573297	2	2	55	1	0	0	0	0	0	0	0	1	5433	1567	55	5		5	FAM115A	7	143573297	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	692379	143573297	15565366	203	10936											
NOBOX	135935	broad.mit.edu	37	chr7	144096938	144096938	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catttttcgccacttggcccGgcgattctggaaccacacct	7	11	8	15	3	1	0	0	0	1	0	2	2	1	1	4	3	1	0	4	3	1	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:144096938G>T	uc011kue.1	-	6	1066	c.1066C>A	c.(1066-1068)CGG>AGG	p.R356R		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	356	Homeobox.				cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					CACTTGGCCCGGCGATTCTGG	0.537													14	33					2.31682e-05	2.46194e-05	1	0	T	144096938	T	T	144096938	2	4	55	1	0	0	0	0	0	0	0	1	10566	1115	39	3		3	NOBOX	7	144096938	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	523641	144096938	15041725	204	10937											
MLL3	58508	broad.mit.edu	37	chr7	151970897	151970897	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gataatgatacatctgggtaCatttctcttcacagcatttg	11	15	7	8	0	3	1	1	1	2	0	4	2	3	1	0	1	3	2	0	1	3	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr7:151970897C>T	uc003wla.2	-	7	1124	c.905G>A	c.(904-906)TGT>TAT	p.C302Y		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	302					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CATCTGGGTACATTTCTCTTC	0.433			N		medulloblastoma								8	330					0	0	0	0	T	151970897	T	T	151970897	3	4	55	1	0	0	0	0	1	0	0	0	9675	478	17	4	14042	4	MLL3	7	151970897	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	7873959	151970897	7167766	205	10938											
SGK223	157285	broad.mit.edu	37	chr8	8235565	8235565	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttcgggagggggagcttGccaggggctcgtctccagat	5	9	17	10	2	1	1	0	0	1	1	4	3	1	3	2	5	3	3	2	5	0	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:8235565G>C	uc003wsh.3	-	2	354	c.354C>G	c.(352-354)GGC>GGG	p.G118G		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	118							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GGGGGAGCTTGCCAGGGGCTC	0.547													39	145					0	0	0	0	C	8235565	C	C	8235565	2	2	55	1	0	0	0	0	0	0	0	1	14275	1306	46	4		4	SGK223	8	8235565	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08		8235565	138128457	206	10939											
PPP1R3B	79660	broad.mit.edu	37	chr8	8998511	8998511	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcccagtacgtctgtccAttgcactcgtagtacacagc	8	11	8	14	2	1	0	0	0	1	0	4	0	3	0	2	0	4	4	2	0	3	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:8998511A>T	uc003wsn.3	-	2	816	c.651T>A	c.(649-651)AAT>AAA	p.N217K	PPP1R3B_uc003wso.3_Missense_Mutation_p.N216K	NM_024607	NP_078883	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	217	CBM21.				glycogen metabolic process					ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		ACGTCTGTCCATTGCACTCGT	0.507													45	124					0	0	0	0	T	8998511	T	T	8998511	3	4	55	1	0	0	0	0	1	0	0	0	12432	214	8	5	210	5	PPP1R3B	8	8998511	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	762946	8998511	137365511	207	10940											
FDFT1	2222	broad.mit.edu	37	chr8	11666366	11666366	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcagaccagtcgcagtttcGcagctgttatccaggcgctg	8	10	11	12	3	1	1	1	0	0	1	4	1	2	1	2	1	1	6	2	1	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:11666366G>A	uc003wui.2	+	2	315	c.163G>A	c.(163-165)GCA>ACA	p.A55T	FDFT1_uc003wuh.2_5'UTR|FDFT1_uc010lsa.1_Intron|FDFT1_uc011kxe.1_5'UTR|FDFT1_uc011kxf.1_Missense_Mutation_p.A55T|FDFT1_uc011kxg.1_Intron|FDFT1_uc003wuj.2_Missense_Mutation_p.A48T|FDFT1_uc010lsb.2_5'UTR|FDFT1_uc011kxh.1_5'UTR|FDFT1_uc011kxi.1_RNA|FDFT1_uc011kxj.1_5'UTR|FDFT1_uc003wuk.2_Missense_Mutation_p.A114T|FDFT1_uc011kxk.1_5'Flank	NM_004462	NP_004453	P37268	FDFT_HUMAN	squalene synthase	55					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity				0	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		TCGCAGTTTCGCAGCTGTTAT	0.572													16	20					0	0	0	0	A	11666366	A	A	11666366	3	1	55	1	0	0	0	0	1	0	0	0	5834	1087	38	1	169	1	FDFT1	8	11666366	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2667855	11666366	134697656	208	10941											
NEFM	4741	broad.mit.edu	37	chr8	24771549	24771549	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgacttcagccagtcctcGtccctgctcaacggcggctc	5	10	9	17	3	2	1	2	1	0	0	6	1	4	1	3	2	3	2	3	2	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:24771549G>T	uc003xed.3	+	1	276	c.243G>T	c.(241-243)TCG>TCT	p.S81S	NEFM_uc011lac.1_Silent_p.S81S|NEFM_uc010lue.2_5'Flank|uc010luc.1_3'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	81	Head.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GCCAGTCCTCGTCCCTGCTCA	0.662													11	27					2.49675e-24	3.17416e-24	1	0	T	24771549	T	T	24771549	2	4	55	1	0	0	0	0	0	0	0	1	10370	1132	40	3		3	NEFM	8	24771549	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	13105183	24771549	121592473	209	10942											
PURG	29942	broad.mit.edu	37	chr8	30889548	30889548	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcatcgtctccacctcttcGttcttctatgtctccttcgc	3	17	5	16	3	6	0	1	0	5	0	11	0	6	0	3	0	0	1	3	0	1	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:30889548G>A	uc003xin.2	-	1	770	c.751C>T	c.(751-753)CGA>TGA	p.R251*	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Nonsense_Mutation_p.R251*	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	251	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		CCACCTCTTCGTTCTTCTATG	0.458													43	112					0	0	0	0	A	30889548	A	A	30889548	4	1	55	1	0	0	0	0	0	1	0	0	12894	1153	40	1	405	1	PURG	8	30889548	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	6117999	30889548	115474474	210	10943											
PXDNL	137902	broad.mit.edu	37	chr8	52336292	52336292	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtaatctgcacaccttcCtagggagcaaaaaagagttg	14	9	9	9	0	2	1	1	0	1	1	3	2	3	2	2	1	2	4	2	1	5	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:52336292C>G	uc003xqu.3	-	14	1740	c.1639_splice	c.e14-1	p.E547_splice		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor						hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GCACACCTTCCTAGGGAGCAA	0.368													9	48					0	0	0	0	G	52336292	G	G	52336292	5	3	55	1	0	0	0	0	0	0	1	0	12913	695	24	4	2793	4	PXDNL	8	52336292	Splice_Site	SNP	C	TCGA-CN-5356-01A-01D-1434-08	21446744	52336292	94027730	211	10944											
YTHDF3	253943	broad.mit.edu	37	chr8	64098988	64098988	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctctacatgggggacaagtgGatctcagggacaatcaacac	13	7	11	10	0	3	0	2	0	2	0	4	3	3	3	0	4	2	0	0	4	4	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:64098988G>A	uc003xuy.2	+	5	735	c.419G>A	c.(418-420)GGA>GAA	p.G140E	YTHDF3_uc010lys.2_Missense_Mutation_p.G84E|YTHDF3_uc003xuz.2_Missense_Mutation_p.G84E|YTHDF3_uc003xva.2_Missense_Mutation_p.G84E|YTHDF3_uc011len.1_Missense_Mutation_p.G84E	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	140											0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			GGGACAAGTGGATCTCAGGGA	0.433													18	64					0	0	0	0	A	64098988	A	A	64098988	3	1	55	1	0	0	0	0	1	0	0	0	17568	1174	41	2	432	2	YTHDF3	8	64098988	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	11762696	64098988	82265034	212	10945											
ARFGEF1	10565	broad.mit.edu	37	chr8	68123821	68123821	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggttgaatagaatcatgAatatctacagacttctgtga	13	14	8	6	0	3	5	1	3	2	2	3	5	3	5	0	1	1	1	0	1	6	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:68123821A>G	uc003xxo.1	-	34	5106	c.4716T>C	c.(4714-4716)ATT>ATC	p.I1572I	ARFGEF1_uc003xxl.1_Silent_p.I1026I|ARFGEF1_uc003xxn.1_Silent_p.I549I	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1572					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding	p.I1572V(1)		ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TAGAATCATGAATATCTACAG	0.323													35	65					0	0	0	0	G	68123821	G	G	68123821	2	3	55	1	0	0	0	0	0	0	0	1	852	242	9	5		5	ARFGEF1	8	68123821	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	4024833	68123821	78240201	213	10946											
NECAB1	64168	broad.mit.edu	37	chr8	91937823	91937823	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctggaaaacgatcaagccgCcgagtccagagacacaacag	15	3	10	13	3	1	1	1	0	0	1	2	5	2	2	4	1	3	0	4	1	4	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:91937823C>T	uc011lgg.1	+	7	749	c.555C>T	c.(553-555)CGC>CGT	p.R185R		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	185					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			GATCAAGCCGCCGAGTCCAGA	0.458													13	25					0	0	0	0	T	91937823	T	T	91937823	2	4	55	1	0	0	0	0	0	0	0	1	10358	726	26	4		4	NECAB1	8	91937823	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	23814002	91937823	54426199	214	10947											
RUNX1T1	862	broad.mit.edu	37	chr8	93023240	93023240	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcaataccttcaaaaatGggatgacaaaaggtctcagt	15	10	9	7	0	2	1	2	1	1	0	3	2	2	2	1	2	2	1	1	2	6	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:93023240G>A	uc003yfd.2	-	4	632	c.548C>T	c.(547-549)CCA>CTA	p.P183L	RUNX1T1_uc003yfc.1_Missense_Mutation_p.P156L|RUNX1T1_uc003yfe.1_Missense_Mutation_p.P146L|RUNX1T1_uc010mao.2_Missense_Mutation_p.P156L|RUNX1T1_uc011lgi.1_Missense_Mutation_p.P194L|RUNX1T1_uc003yfh.1_Missense_Mutation_p.P146L|RUNX1T1_uc003yfb.1_Missense_Mutation_p.P146L|RUNX1T1_uc003yff.1_Missense_Mutation_p.P146L|RUNX1T1_uc003yfg.1_Missense_Mutation_p.P146L	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	183	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CTTCAAAAATGGGATGACAAA	0.363													40	132					0	0	0	0	A	93023240	A	A	93023240	3	1	55	1	0	0	0	0	1	0	0	0	13812	1348	47	4	1298	4	RUNX1T1	8	93023240	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1085417	93023240	53340782	215	10948											
CSMD3	114788	broad.mit.edu	37	chr8	113395840	113395840	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattgttgtctcccccatcaTaaaagtccagagaatcccaa	13	10	5	13	0	2	1	1	0	1	1	5	2	4	1	4	0	0	1	4	0	4	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:113395840T>C	uc003ynu.2	-	37	6146	c.5987A>G	c.(5986-5988)TAT>TGT	p.Y1996C	CSMD3_uc003yns.2_Missense_Mutation_p.Y1198C|CSMD3_uc003ynt.2_Missense_Mutation_p.Y1956C|CSMD3_uc011lhx.1_Missense_Mutation_p.Y1892C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1996	Extracellular (Potential).|CUB 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCCCCCATCATAAAAGTCCAG	0.333										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			42	99					0	0	0	0	C	113395840	C	C	113395840	3	2	55	1	0	0	0	0	1	0	0	0	3963	1406	49	5	5276	5	CSMD3	8	113395840	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	20372600	113395840	32968182	216	10949											
HAS2	3037	broad.mit.edu	37	chr8	122626624	122626624	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcctgatgtgccccaccCagctttgtttattgttgcaa	6	15	7	13	0	0	1	0	1	0	0	1	1	1	1	5	0	3	4	5	0	2	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:122626624C>T	uc003yph.2	-	4	1922	c.1384G>A	c.(1384-1386)GGG>AGG	p.G462R		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	462	Extracellular (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			GTGCCCCACCCAGCTTTGTTT	0.413													135	281					0	0	0	0	T	122626624	T	T	122626624	3	4	55	1	0	0	0	0	1	0	0	0	7001	594	21	4	278	4	HAS2	8	122626624	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	9230784	122626624	23737398	217	10950											
FER1L6	654463	broad.mit.edu	37	chr8	125052147	125052147	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatgtttttcagctgagggCtcacatgtaccaagcccggg	8	10	12	11	1	2	1	2	1	0	0	2	1	2	1	2	2	3	5	2	2	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:125052147C>T	uc003yqw.2	+	20	2695	c.2489C>T	c.(2488-2490)GCT>GTT	p.A830V	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	830	Cytoplasmic (Potential).|C2 3.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CAGCTGAGGGCTCACATGTAC	0.507													68	106					0	0	0	0	T	125052147	T	T	125052147	3	4	55	1	0	0	0	0	1	0	0	0	5847	797	28	4	2563	4	FER1L6	8	125052147	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2425523	125052147	21311875	218	10951											
LRRC6	23639	broad.mit.edu	37	chr8	133622460	133622460	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtctgagatcttttagcAgaactactatcgggtttcac	9	15	9	8	1	3	2	1	1	2	2	4	3	3	2	0	1	3	3	0	1	4	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:133622460A>G	uc003ytk.2	-	10	1166	c.1092T>C	c.(1090-1092)TCT>TCC	p.S364S	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	364	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			ATCTTTTAGCAGAACTACTAT	0.428													42	186					0	0	0	0	G	133622460	G	G	133622460	2	3	55	1	0	0	0	0	0	0	0	1	9066	175	7	5		5	LRRC6	8	133622460	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	8570313	133622460	12741562	219	10952											
ZNF696	79943	broad.mit.edu	37	chr8	144378710	144378710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agcaccagcgcgtgcacacgGgggagcggcccttcgcctgc	6	4	15	16	5	0	0	0	0	0	0	1	1	0	1	3	3	5	2	3	3	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:144378710G>A	uc003yxy.3	+	3	1274	c.865G>A	c.(865-867)GGG>AGG	p.G289R		NM_030895	NP_112157	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CGTGCACACGGGGGAGCGGCC	0.726													5	10					0	0	0	0	A	144378710	A	A	144378710	3	1	55	1	0	0	0	0	1	0	0	0	18166	1232	43	4	871	4	ZNF696	8	144378710	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	10756250	144378710	1985312	220	10953											
PLEC	5339	broad.mit.edu	37	chr8	145008864	145008864	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccttggctggtagctccAtctccttaaacttcaggaac	8	12	7	14	0	2	0	1	0	1	0	5	1	4	1	4	3	3	3	4	3	4	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:145008864A>T	uc003zaf.1	-	10	1561	c.1391T>A	c.(1390-1392)ATG>AAG	p.M464K	PLEC_uc003zab.1_Missense_Mutation_p.M327K|PLEC_uc003zac.1_Missense_Mutation_p.M331K|PLEC_uc003zad.2_Missense_Mutation_p.M327K|PLEC_uc003zae.1_Missense_Mutation_p.M295K|PLEC_uc003zag.1_Missense_Mutation_p.M305K|PLEC_uc003zah.2_Missense_Mutation_p.M313K|PLEC_uc003zaj.2_Missense_Mutation_p.M354K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	464	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TGGTAGCTCCATCTCCTTAAA	0.637													64	135					0	0	0	0	T	145008864	T	T	145008864	3	4	55	1	0	0	0	0	1	0	0	0	12107	217	8	5	12755	5	PLEC	8	145008864	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	630154	145008864	1355158	221	10954											
ZNF251	90987	broad.mit.edu	37	chr8	145948593	145948593	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtttgttcaaactctgcccgGcagaatttcccacgcgctct	7	12	8	14	3	3	1	1	0	2	1	4	1	4	1	2	1	2	4	2	1	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr8:145948593G>A	uc003zdv.3	-	5	708	c.452C>T	c.(451-453)GCC>GTC	p.A151V		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		ACTCTGCCCGGCAGAATTTCC	0.483													4	180					0	0	0	0	A	145948593	A	A	145948593	3	1	55	1	0	0	0	0	1	0	0	0	17863	1203	42	4	1567	4	ZNF251	8	145948593	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	939729	145948593	415429	222	10955											
JAK2	3717	broad.mit.edu	37	chr9	5054676	5054676	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tattcagcaattcagccaatGcaaagccactgccagaaact	15	8	6	12	0	2	1	2	0	0	1	2	1	2	1	3	0	6	2	3	0	5	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:5054676G>A	uc010mhm.2	+	6	841	c.728G>A	c.(727-729)TGC>TAC	p.C243Y	JAK2_uc003ziw.2_Missense_Mutation_p.C243Y	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	243	FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TTCAGCCAATGCAAAGCCACT	0.368		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				70	164					0	0	0	0	A	5054676	A	A	5054676	3	1	55	1	0	0	0	0	1	0	0	0	7977	1319	46	4	746	4	JAK2	9	5054676	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08		5054676	136158755	223	10956											
KIAA1432	57589	broad.mit.edu	37	chr9	5763586	5763586	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggcccagtcctgtgccacAttaccttacttccctcatgt	6	14	6	15	0	1	0	1	0	0	0	3	0	3	0	5	1	3	0	5	1	2	4	rs147383296		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:5763586A>G	uc003zji.2	+	18	2415	c.2322A>G	c.(2320-2322)ACA>ACG	p.T774T	KIAA1432_uc003zjh.2_Silent_p.T774T|KIAA1432_uc003zjl.3_Silent_p.T737T|KIAA1432_uc003zjj.1_Silent_p.T316T	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	853						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CCTGTGCCACATTACCTTACT	0.537													30	127					0	0	0	0	G	5763586	G	G	5763586	2	3	55	1	0	0	0	0	0	0	0	1	8272	204	8	5		5	KIAA1432	9	5763586	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	708910	5763586	135449845	224	10957											
KDM4C	23081	broad.mit.edu	37	chr9	6805761	6805761	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgaaggagttcaggcagctgGccaacagtggcaagtgagta	12	7	15	7	0	1	2	1	2	0	0	1	3	1	3	1	4	2	5	1	4	4	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:6805761G>A	uc003zkh.2	+	3	887	c.307G>A	c.(307-309)GCC>ACC	p.A103T	KDM4C_uc010mhu.2_Missense_Mutation_p.A125T|KDM4C_uc010mhw.2_Missense_Mutation_p.A103T|KDM4C_uc011lmi.1_Missense_Mutation_p.A103T|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.A103T|KDM4C_uc011lmk.1_Intron|KDM4C_uc010mhv.2_Missense_Mutation_p.A103T	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	103					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						CAGGCAGCTGGCCAACAGTGG	0.418													33	66					0	0	0	0	A	6805761	A	A	6805761	3	1	55	1	0	0	0	0	1	0	0	0	8169	1203	42	4	383	4	KDM4C	9	6805761	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1042175	6805761	134407670	225	10958											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18889684	18889684	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggtcaaccctgcccactgCgcagggaaggttcgccctgc	7	6	13	15	2	1	0	1	0	0	0	2	2	1	1	3	3	4	2	3	3	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:18889684C>G	uc003zne.3	+	25	4708	c.4581C>G	c.(4579-4581)TGC>TGG	p.C1527W	ADAMTSL1_uc003znf.3_Missense_Mutation_p.C228W	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1527						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CTGCCCACTGCGCAGGGAAGG	0.657													16	23					0	0	0	0	G	18889684	G	G	18889684	3	3	55	1	0	0	0	0	1	0	0	0	274	776	27	3	4683	3	ADAMTSL1	9	18889684	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	12083923	18889684	122323747	226	10959											
IFNW1	3467	broad.mit.edu	37	chr9	21141013	21141013	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaggtctctatctttacttCtcagtctttcttgcatgttt	5	20	5	11	0	5	0	1	0	5	0	7	0	5	0	1	1	2	2	1	1	2	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:21141013C>G	uc003zol.1	-	1	1132	c.557G>C	c.(556-558)AGA>ACA	p.R186T		NM_002177	NP_002168	P05000	IFNW1_HUMAN	interferon, omega 1 precursor	186					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding				0				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		ATCTTTACTTCTCAGTCTTTC	0.378													20	110					0	0	0	0	G	21141013	G	G	21141013	3	3	55	1	0	0	0	0	1	0	0	0	7591	913	32	2	34	2	IFNW1	9	21141013	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2251329	21141013	120072418	227	10960											
ELAVL2	1993	broad.mit.edu	37	chr9	23762230	23762230	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattagacagttgtgtttcCatggcagcaattacctgcta	10	13	8	10	0	0	1	0	0	0	1	1	1	1	1	3	1	3	5	3	1	4	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:23762230C>A	uc003zpu.2	-	2	278	c.3G>T	c.(1-3)ATG>ATT	p.M1I	ELAVL2_uc003zps.2_Missense_Mutation_p.M1I|ELAVL2_uc003zpt.2_Missense_Mutation_p.M1I|ELAVL2_uc003zpv.2_Missense_Mutation_p.M1I|ELAVL2_uc003zpw.2_Missense_Mutation_p.M1I	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	1					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		GTTGTGTTTCCATGGCAGCAA	0.403													121	301					3.28517e-43	4.33326e-43	1	0	A	23762230	A	A	23762230	3	1	55	1	0	0	0	0	1	0	0	0	5074	594	21	4	1100	4	ELAVL2	9	23762230	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2621217	23762230	117451201	228	10961											
LINGO2	158038	broad.mit.edu	37	chr9	27949987	27949987	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatagtcaatctctaggtgtTtcaggtggaacaatctttta	12	15	8	6	0	4	0	2	0	2	0	5	1	4	1	0	3	1	1	0	3	7	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:27949987T>A	uc003zqu.1	-	2	877	c.683A>T	c.(682-684)AAA>ATA	p.K228I	LINGO2_uc010mjf.1_Missense_Mutation_p.K228I|LINGO2_uc003zqv.1_Missense_Mutation_p.K228I	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	228	LRR 8.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CTCTAGGTGTTTCAGGTGGAA	0.473													27	119					0	0	0	0	A	27949987	A	A	27949987	3	1	55	1	0	0	0	0	1	0	0	0	8857	1841	64	5	1141	5	LINGO2	9	27949987	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	4187757	27949987	113263444	229	10962											
ROR2	4920	broad.mit.edu	37	chr9	94487036	94487036	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agggcggacttcaccgtgcgGtcatcatcggtgctgcccac	6	8	13	14	4	3	0	3	0	0	0	4	1	3	1	2	4	3	1	2	4	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:94487036G>T	uc004arj.1	-	9	1939	c.1740C>A	c.(1738-1740)GAC>GAA	p.D580E	ROR2_uc004ari.1_Missense_Mutation_p.D440E	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	580	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding	p.D580Y(1)		lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						TCACCGTGCGGTCATCATCGG	0.632													6	51					2.7689e-08	3.04764e-08	1	0	T	94487036	T	T	94487036	3	4	55	1	0	0	0	0	1	0	0	0	13592	1252	44	4	1095	4	ROR2	9	94487036	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	66537049	94487036	46726395	230	10963											
OR13C8	138802	broad.mit.edu	37	chr9	107332082	107332082	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgttctggttattccattgTtagtaatttccatctcttac	7	21	5	8	0	2	0	0	0	2	0	5	0	4	0	2	1	1	4	2	1	4	9			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:107332082T>G	uc011lvo.1	+	1	634	c.634T>G	c.(634-636)TTA>GTA	p.L212V		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TATTCCATTGTTAGTAATTTC	0.403													53	139					0	0	0	0	G	107332082	G	G	107332082	3	3	55	1	0	0	0	0	1	0	0	0	10992	1722	60	5	636	5	OR13C8	9	107332082	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	12845046	107332082	33881349	231	10964											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112898525	112898525	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agatcacaaaaacatggaaaTtgaggtgtctgttgcagaat	16	10	10	5	0	2	3	1	1	1	2	2	4	2	4	0	2	2	2	0	2	4	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:112898525T>C	uc004bei.2	+	9	1589	c.1397T>C	c.(1396-1398)ATT>ACT	p.I466T	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.I234T|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.I234T|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.I44T|AKAP2_uc011lwi.1_Missense_Mutation_p.I92T|AKAP2_uc004bem.2_Missense_Mutation_p.I92T|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.I52T|AKAP2_uc011lwj.1_Missense_Mutation_p.I3T|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.I3T	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	3							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AACATGGAAATTGAGGTGTCT	0.502													45	222					0	0	0	0	C	112898525	C	C	112898525	3	2	55	1	0	0	0	0	1	0	0	0	11464	1493	52	5	731	5	PALM2-AKAP2	9	112898525	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	5566443	112898525	28314906	232	10965											
SVEP1	79987	broad.mit.edu	37	chr9	113168483	113168483	+	Frame_Shift_Del	DEL	C	-	-																															ggtgtgtgcctctccagttgCcactgcattggcgacagacg																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:113168483delC	uc010mtz.2	-	38	9734	c.9397delG	c.(9397-9399)GCAfs	p.A3133fs	SVEP1_uc010mty.2_Frame_Shift_Del_p.A1059fs	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3133	Sushi 29.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TCTCCAGTTGCCACTGCATTG	0.512													---	---	---								-	113168483	-	-	113168483	7	5	55	1	0	1	0	1	0	0	0	0	15486	739	26	0	1362	0	SVEP1	9	113168483	Frame_Shift_Del	DEL	C	TCGA-CN-5356-01A-01D-1434-08	269958	113168483	28044948	233	10966											
TNC	3371	broad.mit.edu	37	chr9	117848972	117848972	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgggtgtggcaggcatgtggGcaggtgggtttcccgcagtc	4	10	19	8	1	0	0	0	0	0	0	2	0	1	0	1	6	0	5	1	6	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:117848972G>T	uc004bjj.3	-	3	1400	c.1038C>A	c.(1036-1038)TGC>TGA	p.C346*	TNC_uc010mvf.2_Nonsense_Mutation_p.C346*	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	346	EGF-like 7.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						AGGCATGTGGGCAGGTGGGTT	0.612													12	60					1.5842e-08	1.74759e-08	1	0	T	117848972	T	T	117848972	4	4	55	1	0	0	0	0	0	1	0	0	16336	1195	42	4	5671	4	TNC	9	117848972	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4680489	117848972	23364459	234	10967											
OR5C1	392391	broad.mit.edu	37	chr9	125551651	125551651	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcgcagcgtctatgcctggCcttgctgggagcatcaggcc	5	9	14	13	2	2	0	1	0	1	0	3	1	2	1	3	3	4	3	3	3	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:125551651C>T	uc011lzd.1	+	1	440	c.440C>T	c.(439-441)GCC>GTC	p.A147V		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						CTATGCCTGGCCTTGCTGGGA	0.572													40	74					0	0	0	0	T	125551651	T	T	125551651	3	4	55	1	0	0	0	0	1	0	0	0	11207	739	26	4	442	4	OR5C1	9	125551651	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	7702679	125551651	15661780	235	10968											
LHX2	9355	broad.mit.edu	37	chr9	126776323	126776323	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaccgctactacctgctggcGgtggacaagcagtggcacat	9	7	13	12	2	0	0	0	0	0	0	0	2	0	1	2	4	4	4	2	4	3	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:126776323G>T	uc004boe.1	+	2	943	c.204G>T	c.(202-204)GCG>GCT	p.A68A	LHX2_uc010mwi.1_Silent_p.A68A	NM_004789	NP_004780	P50458	LHX2_HUMAN	LIM homeobox protein 2	68	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACCTGCTGGCGGTGGACAAGC	0.637													18	94					3.51602e-12	4.07031e-12	1	0	T	126776323	T	T	126776323	2	4	55	1	0	0	0	0	0	0	0	1	8812	1103	39	3		3	LHX2	9	126776323	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1224672	126776323	14437108	236	10969											
PRDM12	59335	broad.mit.edu	37	chr9	133542106	133542106	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gacgtggatcaaggcgggaaCcgagatgggccccttcaccg	9	5	15	12	4	2	1	2	0	0	1	2	5	2	3	4	4	1	0	4	4	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:133542106C>A	uc004bzt.1	+	2	395	c.335C>A	c.(334-336)ACC>AAC	p.T112N		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	112	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		AAGGCGGGAACCGAGATGGGC	0.647													36	125					6.07928e-31	7.82985e-31	1	0	A	133542106	A	A	133542106	3	1	55	1	0	0	0	0	1	0	0	0	12515	507	18	4	341	4	PRDM12	9	133542106	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	6765783	133542106	7671325	237	10970											
MAMDC4	158056	broad.mit.edu	37	chr9	139748462	139748462	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgaccttctctgccaccCgaaatgccacccacaggggc	9	6	10	16	1	1	1	0	1	1	0	2	2	1	1	5	3	2	0	5	3	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr9:139748462C>T	uc004cjs.2	+	6	654	c.604C>T	c.(604-606)CGA>TGA	p.R202*	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	202	Extracellular (Potential).|MAM 1.				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CTCTGCCACCCGAAATGCCAC	0.622													25	122					0	0	0	0	T	139748462	T	T	139748462	4	4	55	1	0	0	0	0	0	1	0	0	9257	644	23	1	626	1	MAMDC4	9	139748462	Nonsense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	6206356	139748462	1464969	238	10971											
ITIH5	80760	broad.mit.edu	37	chr10	7708782	7708782	+	Frame_Shift_Del	DEL	C	-	-																															ttacctgctccgaagagtggCcccagctctgcgcctcttcc																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:7708782delC	uc001ijq.2	-	1	153	c.74delG	c.(73-75)GGCfs	p.G25fs	ITIH5_uc001ijr.1_Frame_Shift_Del_p.G25fs	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	25					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CGAAGAGTGGCCCCAGCTCTG	0.567													---	---	---								-	7708782	-	-	7708782	7	5	55	1	0	1	0	1	0	0	0	0	7946	739	26	0	2947	0	ITIH5	10	7708782	Frame_Shift_Del	DEL	C	TCGA-CN-5356-01A-01D-1434-08		7708782	127825965	239	10972											
ECHDC3	79746	broad.mit.edu	37	chr10	11805415	11805415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctacaagcagctgccccagGacctggggacggcttactac	9	7	11	14	1	1	0	0	0	1	0	1	2	1	2	3	4	6	3	3	4	4	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:11805415G>A	uc001ikw.3	+	5	1004	c.784G>A	c.(784-786)GAC>AAC	p.D262N	ECHDC3_uc009xix.2_Missense_Mutation_p.D131N	NM_024693	NP_078969	Q96DC8	ECHD3_HUMAN	enoyl Coenzyme A hydratase domain containing 3	262						mitochondrion	catalytic activity				0						GCTGCCCCAGGACCTGGGGAC	0.637													25	55					0	0	0	0	A	11805415	A	A	11805415	3	1	55	1	0	0	0	0	1	0	0	0	4917	1174	41	2	802	2	ECHDC3	10	11805415	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4096633	11805415	123729332	240	10973											
SEPHS1	22929	broad.mit.edu	37	chr10	13361236	13361236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtctatgattctggctgtgCggttgcccttctctacaatc	5	16	9	11	1	3	1	0	1	3	0	5	1	3	1	1	2	3	2	1	2	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:13361236C>T	uc001imk.2	-	9	1444	c.1085G>A	c.(1084-1086)CGC>CAC	p.R362H	SEPHS1_uc001imh.2_Missense_Mutation_p.R286H|SEPHS1_uc010qbs.1_Missense_Mutation_p.R314H|SEPHS1_uc001imi.2_Missense_Mutation_p.R360H|SEPHS1_uc001imj.2_3'UTR|SEPHS1_uc010qbt.1_Missense_Mutation_p.R295H	NM_012247	NP_036379	P49903	SPS1_HUMAN	selenophosphate synthetase 1	362					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			skin(1)	1						TCTGGCTGTGCGGTTGCCCTT	0.522													12	735					0	0	0	0	T	13361236	T	T	13361236	3	4	55	1	0	0	0	0	1	0	0	0	14119	768	27	1	97	1	SEPHS1	10	13361236	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	1555821	13361236	122173511	241	10974											
CUBN	8029	broad.mit.edu	37	chr10	16873368	16873368	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtttggcagcagagttcCacagtacttgcccagtaatg	10	10	12	9	0	0	1	0	0	0	1	1	1	1	1	2	2	3	6	2	2	2	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:16873368C>T	uc001ioo.2	-	65	10463	c.10411G>A	c.(10411-10413)GGA>AGA	p.G3471R		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3471	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGCAGAGTTCCACAGTACTTG	0.373													48	202					0	0	0	0	T	16873368	T	T	16873368	3	4	55	1	0	0	0	0	1	0	0	0	4068	603	21	4	472	4	CUBN	10	16873368	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3512132	16873368	118661379	242	10975											
NEBL	10529	broad.mit.edu	37	chr10	21139422	21139422	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttttctcatattcttcttTatatttcaccttcattggaa	9	22	2	8	0	5	0	3	0	3	0	6	1	5	1	1	1	0	0	1	1	4	11			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:21139422T>C	uc001iqi.2	-	11	1415	c.1018A>G	c.(1018-1020)AAA>GAA	p.K340E	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	340	Nebulin 9.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TATTCTTCTTTATATTTCACC	0.318													45	132					0	0	0	0	C	21139422	C	C	21139422	3	2	55	1	0	0	0	0	1	0	0	0	10357	1763	61	5	2098	5	NEBL	10	21139422	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	4266054	21139422	114395325	243	10976											
ZEB1	6935	broad.mit.edu	37	chr10	31810534	31810534	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actatcactagtgtttaccaGaacagtgtttattctgtcca	11	15	6	9	0	2	1	1	0	1	1	3	1	3	1	2	0	2	2	2	0	5	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:31810534G>C	uc001ivs.3	+	7	2334	c.2271G>C	c.(2269-2271)CAG>CAC	p.Q757H	ZEB1_uc001ivr.3_Missense_Mutation_p.Q539H|ZEB1_uc010qee.1_Missense_Mutation_p.Q539H|ZEB1_uc010qef.1_Missense_Mutation_p.Q539H|ZEB1_uc009xlj.1_Missense_Mutation_p.Q683H|ZEB1_uc010qeg.1_Missense_Mutation_p.Q616H|ZEB1_uc009xlk.1_Missense_Mutation_p.Q539H|ZEB1_uc001ivt.3_Missense_Mutation_p.Q539H|ZEB1_uc001ivu.3_Missense_Mutation_p.Q758H|ZEB1_uc001ivv.3_Missense_Mutation_p.Q737H|ZEB1_uc010qeh.1_Missense_Mutation_p.Q690H|ZEB1_uc009xlo.1_Missense_Mutation_p.Q740H|ZEB1_uc009xlp.2_Missense_Mutation_p.Q741H	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	757					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				GTGTTTACCAGAACAGTGTTT	0.418													58	92					0	0	0	0	C	31810534	C	C	31810534	3	2	55	1	0	0	0	0	1	0	0	0	17690	933	33	2	2311	2	ZEB1	10	31810534	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	10671112	31810534	103724213	244	10977											
ARHGAP12	94134	broad.mit.edu	37	chr10	32128565	32128565	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgcttctatcatactaacTgtatcttggtgctttggtga	8	18	8	7	0	3	1	1	1	2	0	3	1	3	1	0	2	4	3	0	2	5	8			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:32128565T>C	uc001ivz.1	-	8	1641	c.1371A>G	c.(1369-1371)ACA>ACG	p.T457T	ARHGAP12_uc001ivy.1_Silent_p.T408T|ARHGAP12_uc009xls.2_Silent_p.T408T|ARHGAP12_uc001iwb.1_Silent_p.T455T|ARHGAP12_uc001iwc.1_Intron|ARHGAP12_uc009xlq.1_Intron|ARHGAP12_uc001iwd.1_Intron|ARHGAP12_uc009xlr.1_Silent_p.T455T	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	457					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				TCATACTAACTGTATCTTGGT	0.328													32	73					0	0	0	0	C	32128565	C	C	32128565	2	2	55	1	0	0	0	0	0	0	0	1	865	1594	55	5		5	ARHGAP12	10	32128565	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	318031	32128565	103406182	245	10978											
ANKRD30A	91074	broad.mit.edu	37	chr10	37505229	37505229	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaatgaaaaagaagttttGtgtactgaaaaagaaactgt	20	10	8	3	0	0	4	0	2	0	2	0	4	0	4	0	0	2	2	0	0	8	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:37505229G>A	uc001iza.1	+	32	2921	c.2822G>A	c.(2821-2823)TGT>TAT	p.C941Y		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	997						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AAGAAGTTTTGTGTACTGAAA	0.353													25	103					0	0	0	0	A	37505229	A	A	37505229	3	1	55	1	0	0	0	0	1	0	0	0	658	1377	48	4	2948	4	ANKRD30A	10	37505229	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	5376664	37505229	98029518	246	10979											
A1CF	29974	broad.mit.edu	37	chr10	52570857	52570857	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgtacaagaatagctgtCtttggtcttgtccaatagca	10	16	8	7	0	2	1	0	0	2	1	3	1	3	1	1	1	3	3	1	1	6	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:52570857C>G	uc001jjj.2	-	11	1615	c.1427G>C	c.(1426-1428)AGA>ACA	p.R476T	A1CF_uc010qhn.1_Missense_Mutation_p.R476T|A1CF_uc001jji.2_Missense_Mutation_p.R468T|A1CF_uc001jjh.2_Missense_Mutation_p.R476T|A1CF_uc010qho.1_Missense_Mutation_p.R484T|A1CF_uc009xov.2_Missense_Mutation_p.R468T	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	476					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						GAATAGCTGTCTTTGGTCTTG	0.388													15	67					0	0	0	0	G	52570857	G	G	52570857	3	3	55	1	0	0	0	0	1	0	0	0	2	913	32	2	369	2	A1CF	10	52570857	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	15065628	52570857	82963890	247	10980											
PCDH15	65217	broad.mit.edu	37	chr10	56106239	56106239	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatattgtggtaccaactggAgtgagctgaaaggaaaaaag	17	8	12	4	0	0	2	0	2	0	0	0	4	0	4	1	3	3	2	1	3	8	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:56106239A>T	uc001jju.1	-	6	875	c.480T>A	c.(478-480)ACT>ACA	p.T160T	PCDH15_uc010qhq.1_Silent_p.T165T|PCDH15_uc010qhr.1_Silent_p.T160T|PCDH15_uc010qhs.1_Silent_p.T165T|PCDH15_uc010qht.1_Silent_p.T160T|PCDH15_uc010qhu.1_Silent_p.T160T|PCDH15_uc001jjv.1_Silent_p.T138T|PCDH15_uc010qhv.1_Silent_p.T160T|PCDH15_uc010qhw.1_Silent_p.T160T|PCDH15_uc010qhx.1_Silent_p.T160T|PCDH15_uc010qhy.1_Silent_p.T165T|PCDH15_uc010qhz.1_Silent_p.T160T|PCDH15_uc010qia.1_Silent_p.T138T|PCDH15_uc010qib.1_Silent_p.T138T|PCDH15_uc001jjw.2_Silent_p.T160T	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	160	Extracellular (Potential).|Cadherin 2.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TACCAACTGGAGTGAGCTGAA	0.333										HNSCC(58;0.16)			34	185					0	0	0	0	T	56106239	T	T	56106239	2	4	55	1	0	0	0	0	0	0	0	1	11565	291	11	5		5	PCDH15	10	56106239	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	3535382	56106239	79428508	248	10981											
PCDH15	65217	broad.mit.edu	37	chr10	56138617	56138617	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatcaacacccagtaatcCacattatcctttaaagaaag	16	10	3	12	0	1	1	1	0	0	1	4	1	4	1	4	0	1	1	4	0	6	4	rs151119732	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:56138617C>A	uc001jju.1	-	4	638	c.243G>T	c.(241-243)GTG>GTT	p.V81V	PCDH15_uc010qhq.1_Silent_p.V86V|PCDH15_uc010qhr.1_Silent_p.V81V|PCDH15_uc010qhs.1_Silent_p.V86V|PCDH15_uc010qht.1_Silent_p.V81V|PCDH15_uc010qhu.1_Silent_p.V81V|PCDH15_uc001jjv.1_Silent_p.V59V|PCDH15_uc010qhv.1_Silent_p.V81V|PCDH15_uc010qhw.1_Silent_p.V81V|PCDH15_uc010qhx.1_Silent_p.V81V|PCDH15_uc010qhy.1_Silent_p.V86V|PCDH15_uc010qhz.1_Silent_p.V81V|PCDH15_uc010qia.1_Silent_p.V59V|PCDH15_uc010qib.1_Silent_p.V59V|PCDH15_uc001jjw.2_Silent_p.V81V	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	81	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CCCAGTAATCCACATTATCCT	0.433										HNSCC(58;0.16)			80	221					4.03997e-35	5.25838e-35	1	0	A	56138617	A	A	56138617	2	1	55	1	0	0	0	0	0	0	0	1	11565	581	21	4		4	PCDH15	10	56138617	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	32378	56138617	79396130	249	10982											
C10orf58	84293	broad.mit.edu	37	chr10	82187166	82187166	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgtggtacaacttcttcCgagcctggaacggaggcttc	8	10	13	10	2	1	0	0	0	1	0	3	4	2	2	2	4	4	2	2	4	3	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:82187166C>T	uc001kcc.3	+	5	650	c.490C>T	c.(490-492)CGA>TGA	p.R164*	C10orf58_uc001kcd.3_Nonsense_Mutation_p.R153*|C10orf58_uc001kce.3_Nonsense_Mutation_p.R164*|C10orf58_uc001kcf.3_Nonsense_Mutation_p.R164*	NM_032333	NP_115709	Q9BRX8	CJ058_HUMAN	hypothetical protein LOC84293 precursor	164						extracellular region					0			Colorectal(32;0.229)			CAACTTCTTCCGAGCCTGGAA	0.488													22	167					0	0	0	0	T	82187166	T	T	82187166	4	4	55	1	0	0	0	0	0	1	0	0	1616	644	23	1	504	1	C10orf58	10	82187166	Nonsense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	26048549	82187166	53347581	250	10983											
HTR7	3363	broad.mit.edu	37	chr10	92617175	92617175	+	Frame_Shift_Del	DEL	C	-	-																															tgatgagcgtcaggatggagCcgatcacaactttctcgact																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:92617175delC	uc001kha.2	-	1	497	c.254delG	c.(253-255)GGCfs	p.G85fs	HTR7_uc001kgz.2_Frame_Shift_Del_p.G85fs|HTR7_uc001khb.2_Frame_Shift_Del_p.G85fs	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	85	Helical; Name=1; (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	CAGGATGGAGCCGATCACAAC	0.632													---	---	---								-	92617175	-	-	92617175	7	5	55	1	0	1	0	1	0	0	0	0	7491	739	26	0	1205	0	HTR7	10	92617175	Frame_Shift_Del	DEL	C	TCGA-CN-5356-01A-01D-1434-08	10430009	92617175	42917572	251	10984											
SORCS3	22986	broad.mit.edu	37	chr10	107022247	107022247	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagctggacacgcgggtcaTaggtacatgctcctgctcca	9	8	12	12	2	1	1	1	0	0	1	3	2	3	2	2	3	4	4	2	3	2	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:107022247T>C	uc001kyi.1	+	26	3829	c.3602T>C	c.(3601-3603)ATA>ACA	p.I1201T		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1201	Cytoplasmic (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACGCGGGTCATAGGTACATGC	0.542													25	63					0	0	0	0	C	107022247	C	C	107022247	3	2	55	1	0	0	0	0	1	0	0	0	14996	1406	49	5	3704	5	SORCS3	10	107022247	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	14405072	107022247	28512500	252	10985											
ZDHHC6	64429	broad.mit.edu	37	chr10	114205170	114205170	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttgtagattttcaaactTgataaccgaacagaatgtac	14	14	6	7	1	2	3	1	1	1	2	2	4	2	3	1	0	4	2	1	0	6	8			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:114205170T>C	uc001kzv.2	-	2	449	c.25A>G	c.(25-27)AAG>GAG	p.K9E	VTI1A_uc001kzy.2_5'Flank|VTI1A_uc001kzz.2_5'Flank|ZDHHC6_uc001kzw.2_Missense_Mutation_p.K9E|ZDHHC6_uc009xya.1_Missense_Mutation_p.K9E|VTI1A_uc001kzx.2_5'Flank	NM_022494	NP_071939	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	9						integral to membrane	acyltransferase activity|zinc ion binding				0		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		TTTTCAAACTTGATAACCGAA	0.398													3	88					0	0	0	0	C	114205170	C	C	114205170	3	2	55	1	0	0	0	0	1	0	0	0	17686	1821	63	5	1256	5	ZDHHC6	10	114205170	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	7182923	114205170	21329577	253	10986											
GFRA1	2674	broad.mit.edu	37	chr10	117884808	117884808	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctcttcataggagcacaCaggcacgatggtctgtcgcc	8	9	10	14	2	3	0	1	0	2	0	5	2	3	1	2	3	1	2	2	3	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr10:117884808C>G	uc001lcj.2	-	6	1392	c.694G>C	c.(694-696)GTG>CTG	p.V232L	GFRA1_uc001lci.2_Missense_Mutation_p.V227L|GFRA1_uc009xyr.2_Missense_Mutation_p.V227L	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	232	2.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TAGGAGCACACAGGCACGATG	0.562													32	73					0	0	0	0	G	117884808	G	G	117884808	3	3	55	1	0	0	0	0	1	0	0	0	6384	478	17	4	727	4	GFRA1	10	117884808	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3679638	117884808	17649939	254	10987											
TH	7054	broad.mit.edu	37	chr11	2189385	2189385	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgacacttgtccagctctGacacttttcttgggaaccag	9	12	9	11	0	2	2	0	2	2	0	3	4	3	3	2	1	2	1	2	1	1	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:2189385G>T	uc001lvq.2	-	5	624	c.605C>A	c.(604-606)TCA>TAA	p.S202*	TH_uc001lvp.2_Nonsense_Mutation_p.S198*|TH_uc001lvr.2_Nonsense_Mutation_p.S171*|TH_uc010qxj.1_Nonsense_Mutation_p.S175*|TH_uc001lvs.2_Nonsense_Mutation_p.S171*|TH_uc001lvt.2_Nonsense_Mutation_p.S175*|TH_uc009ydh.1_RNA	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	202					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	GTCCAGCTCTGACACTTTTCT	0.597													25	57					2.79863e-10	3.15086e-10	1	0	T	2189385	T	T	2189385	4	4	55	1	0	0	0	0	0	1	0	0	15904	1294	45	2	1021	2	TH	11	2189385	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08		2189385	132817131	255	10988											
OR52I2	143502	broad.mit.edu	37	chr11	4608360	4608360	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacattgttatggcctcctcGgtggtacccaagatggtgag	8	11	13	9	1	0	2	0	1	0	1	2	3	1	2	3	4	1	2	3	4	3	3	rs149411057	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:4608360G>C	uc010qyh.1	+	1	318	c.318G>C	c.(316-318)TCG>TCC	p.S106S		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	106	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCCTCCTCGGTGGTACCCA	0.493													68	204					0	0	0	0	C	4608360	C	C	4608360	2	2	55	1	0	0	0	0	0	0	0	1	11175	1103	39	3		3	OR52I2	11	4608360	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2418975	4608360	130398156	256	10989											
OR10A5	144124	broad.mit.edu	37	chr11	6867339	6867339	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atcatgaaccaaaggacacgGgccaaactggctgctgcttc	12	7	10	12	1	1	1	1	1	0	0	2	2	1	2	2	3	4	3	2	3	3	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:6867339G>T	uc001met.1	+	1	426	c.426G>T	c.(424-426)CGG>CGT	p.R142R		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAAGGACACGGGCCAAACTGG	0.537													16	194					2.35188e-11	2.69099e-11	1	0	T	6867339	T	T	6867339	2	4	55	1	0	0	0	0	0	0	0	1	10947	1219	43	4		4	OR10A5	11	6867339	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2258979	6867339	128139177	257	10990											
OR10A5	144124	broad.mit.edu	37	chr11	6867357	6867357	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgggccaaactggctgctgcTtcctggttcccaggctttcc	4	11	11	15	1	0	0	0	0	0	0	3	0	3	0	4	4	3	5	4	4	1	3	rs145237850		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:6867357T>C	uc001met.1	+	1	444	c.444T>C	c.(442-444)GCT>GCC	p.A148A		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TGGCTGCTGCTTCCTGGTTCC	0.527													12	157					0	0	0	0	C	6867357	C	C	6867357	2	2	55	1	0	0	0	0	0	0	0	1	10947	1596	56	5		5	OR10A5	11	6867357	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	18	6867357	128139159	258	10991											
OR10A2	341276	broad.mit.edu	37	chr11	6891366	6891366	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatcatgaaccaaaggacTcgtgccaaactggctgctgc	11	8	10	12	1	2	1	2	1	0	0	3	2	2	2	2	2	5	2	2	2	3	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:6891366T>A	uc001meu.1	+	1	381	c.381T>A	c.(379-381)ACT>ACA	p.T127T		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	127	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ACCAAAGGACTCGTGCCAAAC	0.537													7	235					0	0	0	0	A	6891366	A	A	6891366	2	1	55	1	0	0	0	0	0	0	0	1	10944	1538	54	5		5	OR10A2	11	6891366	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	24009	6891366	128115150	259	10992											
NELL1	4745	broad.mit.edu	37	chr11	20939793	20939793	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataacacagtgtccaaatctAaatcacagtaagtagcaact	18	9	5	9	0	2	0	1	0	1	0	3	0	3	0	1	0	3	3	1	0	7	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:20939793A>G	uc001mqe.2	+	6	822	c.669A>G	c.(667-669)CTA>CTG	p.L223L	NELL1_uc001mqf.2_Silent_p.L223L|NELL1_uc009yid.2_Silent_p.L251L|NELL1_uc010rdo.1_Silent_p.L166L|NELL1_uc010rdp.1_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	223	TSP N-terminal.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GTCCAAATCTAAATCACAGTA	0.343													65	101					0	0	0	0	G	20939793	G	G	20939793	2	3	55	1	0	0	0	0	0	0	0	1	10387	349	13	5		5	NELL1	11	20939793	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	14048427	20939793	114066723	260	10993											
NELL1	4745	broad.mit.edu	37	chr11	21581766	21581766	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgccttaagaactcacacCtgttggaacgattctgcctg	9	12	9	11	1	2	1	1	0	1	1	2	3	2	2	3	1	4	1	3	1	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:21581766C>T	uc001mqe.2	+	17	1971	c.1818C>T	c.(1816-1818)ACC>ACT	p.T606T	NELL1_uc001mqf.2_Silent_p.T559T|NELL1_uc009yid.2_Silent_p.T634T|NELL1_uc010rdo.1_Silent_p.T549T|NELL1_uc010rdp.1_Silent_p.T319T|NELL1_uc001mqh.2_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	606	EGF-like 6; calcium-binding (Potential).				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GAACTCACACCTGTTGGAACG	0.502													66	130					0	0	0	0	T	21581766	T	T	21581766	2	4	55	1	0	0	0	0	0	0	0	1	10387	668	24	4		4	NELL1	11	21581766	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	641973	21581766	113424750	261	10994											
SLC17A6	57084	broad.mit.edu	37	chr11	22360160	22360160	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaaatcactcggccagatCtacaggtaagacaaagcgaa	17	5	10	9	2	2	2	1	0	1	2	3	4	2	3	1	3	2	1	1	3	6	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:22360160C>G	uc001mqk.2	+	1	494	c.81C>G	c.(79-81)ATC>ATG	p.I27M		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	27	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TCGGCCAGATCTACAGGTAAG	0.453													15	32					0	0	0	0	G	22360160	G	G	22360160	3	3	55	1	0	0	0	0	1	0	0	0	14486	903	32	2	83	2	SLC17A6	11	22360160	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	778394	22360160	112646356	262	10995											
HIPK3	10114	broad.mit.edu	37	chr11	33375104	33375104	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaaaactcagccagtatcCatatatgtgaaaaacagtat	19	9	5	8	0	1	1	1	1	0	0	2	1	2	1	2	0	4	2	2	0	9	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:33375104C>A	uc001mul.1	+	17	3908	c.3638C>A	c.(3637-3639)CCA>CAA	p.P1213Q	HIPK3_uc001mum.1_Missense_Mutation_p.P1192Q|HIPK3_uc009yjv.1_Missense_Mutation_p.P1192Q	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	1213					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						AGCCAGTATCCATATATGTGA	0.353													51	57					2.27781e-18	2.78085e-18	1	0	A	33375104	A	A	33375104	3	1	55	1	0	0	0	0	1	0	0	0	7157	594	21	4	3700	4	HIPK3	11	33375104	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	11014944	33375104	101631412	263	10996											
ALX4	60529	broad.mit.edu	37	chr11	44297071	44297071	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctctgagtcggccttctccaAtgggctggggaggtctgagc	5	10	15	11	1	3	2	0	2	3	0	5	3	3	3	2	5	1	1	2	5	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:44297071A>G	uc001myb.2	-	2	708	c.604T>C	c.(604-606)TTG>CTG	p.L202L		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	202					hair follicle development						0						GCCTTCTCCAATGGGCTGGGG	0.617													93	178					0	0	0	0	G	44297071	G	G	44297071	2	3	55	1	0	0	0	0	0	0	0	1	558	98	4	5		5	ALX4	11	44297071	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	10921967	44297071	90709445	264	10997											
LRP4	4038	broad.mit.edu	37	chr11	46896618	46896618	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccgaggcaagcagaggtggGagcagccgccatttctcgag	9	5	16	11	3	1	1	0	0	1	1	2	4	1	2	3	3	3	3	3	3	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:46896618G>A	uc001ndn.3	-	28	4108	c.3962C>T	c.(3961-3963)TCC>TTC	p.S1321F		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1321	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GCAGAGGTGGGAGCAGCCGCC	0.547													13	28					0	0	0	0	A	46896618	A	A	46896618	3	1	55	1	0	0	0	0	1	0	0	0	9009	1174	41	2	1799	2	LRP4	11	46896618	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2599547	46896618	88109898	265	10998											
OR4C16	219428	broad.mit.edu	37	chr11	55339627	55339628	+	Nonsense_Mutation	DNP	TG	CT	CT																															caactgaataataatgtgacTgagttcattctgcttggatt																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:55339627_55339628TG>CT	uc010rih.1	+	1	24_25	c.24_25TG>CT	c.(22-27)ACTGAG>ACCTAG	p.E9*		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				ATAATGTGACTGAGTTCATTCT	0.376													5	115					0	0	0	0	CT	55339628	CT	CT	55339627	4	2	55	1	0	0	0	0	0	1	0	0	11103	1567	55	5	26	5	OR4C16	11	55339627	Nonsense_Mutation	DNP	TG	TCGA-CN-5356-01A-01D-1434-08	8443009	55339627	79666889	266	10999											
OR4C6	219432	broad.mit.edu	37	chr11	55433099	55433100	+	Frame_Shift_Ins	INS	-	A	A																															ttgggtggggggatttatgcINSacgcaatgatacaacttctc																								rs149652704		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:55433099_55433100insA	uc001nht.3	+	3	722_723	c.457_458insA	c.(457-459)CACfs	p.H153fs	OR4C6_uc010rik.1_Frame_Shift_Ins_p.H153fs	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GGGATTTATGCACGCAATGATA	0.47													---	---	---								A	55433100	A	A	55433099	7	5	55	1	0	1	1	0	0	0	0	0	11106	710	25	0	459	0	OR4C6	11	55433099	Frame_Shift_Ins	INS	-	TCGA-CN-5356-01A-01D-1434-08	93472	55433099	79573417	267	11000											
OR5M3	219482	broad.mit.edu	37	chr11	56237559	56237559	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagtaatcagtcgaatacAgacaacccttgacattttac	16	10	6	9	1	1	2	1	1	0	1	2	4	1	2	1	0	3	1	1	0	6	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:56237559A>G	uc010rjk.1	-	1	415	c.415T>C	c.(415-417)TGT>CGT	p.C139R		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	139	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AGTCGAATACAGACAACCCTT	0.398													67	130					0	0	0	0	G	56237559	G	G	56237559	3	3	55	1	0	0	0	0	1	0	0	0	11229	188	7	5	510	5	OR5M3	11	56237559	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	804460	56237559	78768957	268	11001											
OR5A2	219981	broad.mit.edu	37	chr11	59190426	59190426	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttgttccttcctacagccaTaggcctgcttcctgcataaa	8	13	7	13	0	0	0	0	0	0	0	3	0	3	0	5	1	4	4	5	1	4	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:59190426T>C	uc010rkt.1	-	1	1	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTACAGCCATAGGCCTGCTT	0.378													77	182					0	0	0	0	C	59190426	C	C	59190426	3	2	55	1	0	0	0	0	1	0	0	0	11194	1420	49	5	975	5	OR5A2	11	59190426	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	2952867	59190426	75816090	269	11002											
PITPNM1	9600	broad.mit.edu	37	chr11	67261436	67261436	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacaccaatgcccagcgcgcGttctgggggaactgggaagg	9	5	16	11	3	1	0	0	0	1	0	1	3	1	2	2	4	3	1	2	4	3	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:67261436G>A	uc001olx.2	-	19	3154	c.2965C>T	c.(2965-2967)CGC>TGC	p.R989C	PITPNM1_uc001olw.2_Missense_Mutation_p.R271C|PITPNM1_uc001oly.2_Missense_Mutation_p.R989C|PITPNM1_uc001olz.2_Missense_Mutation_p.R988C	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	989					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						CCCAGCGCGCGTTCTGGGGGA	0.572													9	20					0	0	0	0	A	67261436	A	A	67261436	3	1	55	1	0	0	0	0	1	0	0	0	12005	1145	40	1	789	1	PITPNM1	11	67261436	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	8071010	67261436	67745080	270	11003											
SLCO2B1	11309	broad.mit.edu	37	chr11	74873807	74873807	+	Frame_Shift_Del	DEL	C	-	-																															cagaccctcaggacgtgcggCcaagtgtgttccataacatc																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:74873807delC	uc001owb.2	+	2	511	c.124delC	c.(124-126)CCAfs	p.P42fs	SLCO2B1_uc010rrp.1_RNA|SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Intron|SLCO2B1_uc010rrs.1_Intron|SLCO2B1_uc001owc.2_Intron|SLCO2B1_uc001owd.2_Frame_Shift_Del_p.P20fs	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	42	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	GGACGTGCGGCCAAGTGTGTT	0.483													---	---	---								-	74873807	-	-	74873807	7	5	55	1	0	1	0	1	0	0	0	0	14791	739	26	0	130	0	SLCO2B1	11	74873807	Frame_Shift_Del	DEL	C	TCGA-CN-5356-01A-01D-1434-08	7612371	74873807	60132709	271	11004											
NARS2	79731	broad.mit.edu	37	chr11	78279726	78279726	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attttttctgccttcagttcCacattttgccttttggatgg	5	20	7	9	0	2	0	1	0	1	0	3	1	3	1	3	2	2	1	3	2	0	9			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:78279726C>A	uc001ozi.2	-	3	700	c.324G>T	c.(322-324)GTG>GTT	p.V108V	NARS2_uc010rsq.1_5'UTR	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	108					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	CCTTCAGTTCCACATTTTGCC	0.348													53	117					1.63038e-21	2.03075e-21	1	0	A	78279726	A	A	78279726	2	1	55	1	0	0	0	0	0	0	0	1	10224	581	21	4		4	NARS2	11	78279726	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3405919	78279726	56726790	272	11005											
DLG2	1740	broad.mit.edu	37	chr11	83673957	83673957	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcgtcgtcaacaagcatgtgCtttggaattggtgagtacct	9	13	11	8	2	1	1	1	1	0	0	3	2	1	2	1	2	4	3	1	2	4	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:83673957C>A	uc001paj.2	-	9	1299	c.996G>T	c.(994-996)AAG>AAT	p.K332N	DLG2_uc001pai.2_Missense_Mutation_p.K281N|DLG2_uc010rsy.1_Missense_Mutation_p.K299N|DLG2_uc010rsz.1_Missense_Mutation_p.K332N|DLG2_uc010rta.1_Missense_Mutation_p.K332N|DLG2_uc001pak.2_Missense_Mutation_p.K437N|DLG2_uc010rtb.1_Missense_Mutation_p.K299N|DLG2_uc001pal.1_Missense_Mutation_p.K332N|DLG2_uc001pam.1_Missense_Mutation_p.K371N	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	332						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CAAGCATGTGCTTTGGAATTG	0.428													73	189					1.1397e-45	1.50735e-45	1	0	A	83673957	A	A	83673957	3	1	55	1	0	0	0	0	1	0	0	0	4577	796	28	4	1726	4	DLG2	11	83673957	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	5394231	83673957	51332559	273	11006											
GRM5	2915	broad.mit.edu	37	chr11	88386571	88386571	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgtcagcccagccatcActgtggggaaataaaaaaac	15	7	8	11	0	2	0	2	0	0	0	2	1	2	1	3	2	4	0	3	2	6	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:88386571A>T	uc001pcq.2	-	3	1112	c.912T>A	c.(910-912)AGT>AGA	p.S304R	GRM5_uc009yvm.2_Missense_Mutation_p.S304R	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	304	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CCCAGCCATCACTGTGGGGAA	0.433													28	30					0	0	0	0	T	88386571	T	T	88386571	3	4	55	1	0	0	0	0	1	0	0	0	6839	173	6	5	2754	5	GRM5	11	88386571	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	4712614	88386571	46619945	274	11007											
UBTFL1	642623	broad.mit.edu	37	chr11	89819194	89819194	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatgcatggagaataatcGcccatctgatgacaacagca	15	7	10	9	1	1	3	0	2	1	1	2	5	1	4	1	2	3	2	1	2	4	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:89819194G>C	uc010rub.1	+	1	77	c.77G>C	c.(76-78)CGC>CCC	p.R26P		NM_001143975	NP_001137447	P0CB47	UBFL1_HUMAN	upstream binding transcription factor, RNA	26					multicellular organismal development	cytoplasm|nucleus	DNA binding				0						GAGAATAATCGCCCATCTGAT	0.418													30	80					0	0	0	0	C	89819194	C	C	89819194	3	2	55	1	0	0	0	0	1	0	0	0	16978	1087	38	3	79	3	UBTFL1	11	89819194	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1432623	89819194	45187322	275	11008											
FAT3	120114	broad.mit.edu	37	chr11	92085313	92085313	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggacactgtgtgggcacacGgcctcctgcttgttgcctca	5	10	13	13	1	1	0	1	0	0	0	2	1	2	1	3	3	2	3	3	3	0	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:92085313G>T	uc001pdj.3	+	1	52	c.35G>T	c.(34-36)CGG>CTG	p.R12L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	12					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGGCACACGGCCTCCTGCT	0.502										TCGA Ovarian(4;0.039)			11	85					9.31168e-06	9.98115e-06	1	0	T	92085313	T	T	92085313	3	4	55	1	0	0	0	0	1	0	0	0	5723	1116	39	3	37	3	FAT3	11	92085313	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2266119	92085313	42921203	276	11009											
FAT3	120114	broad.mit.edu	37	chr11	92086560	92086560	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattaatcctcggtcgggtCtgattgttacagcacggcca	10	11	10	10	3	1	1	0	1	1	0	4	1	2	1	2	3	2	2	2	3	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:92086560C>A	uc001pdj.3	+	1	1299	c.1282C>A	c.(1282-1284)CTG>ATG	p.L428M		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	428	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCGGTCGGGTCTGATTGTTAC	0.408										TCGA Ovarian(4;0.039)			9	20					1.58986e-06	1.72294e-06	1	0	A	92086560	A	A	92086560	3	1	55	1	0	0	0	0	1	0	0	0	5723	912	32	2	1284	2	FAT3	11	92086560	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	1247	92086560	42919956	277	11010											
CEP57	9702	broad.mit.edu	37	chr11	95564303	95564303	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcacagggaccacaaataaGaaagattttatgaaactgag	19	8	8	6	0	1	4	1	2	0	2	1	5	1	5	1	1	1	0	1	1	5	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:95564303G>A	uc001pfp.1	+	11	1607	c.1386G>A	c.(1384-1386)AAG>AAA	p.K462K	CEP57_uc010ruh.1_Silent_p.K453K|CEP57_uc010rui.1_Silent_p.K436K|CEP57_uc009ywn.1_Silent_p.K310K|CEP57_uc001pfq.1_Silent_p.K436K|CEP57_uc001pfr.1_Silent_p.K310K	NM_014679	NP_055494	Q86XR8	CEP57_HUMAN	translokin	462	Mediates interaction with microtubules (By similarity).|Potential.				fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCACAAATAAGAAAGATTTTA	0.363									Mosaic_Variegated_Aneuploidy_Syndrome				9	60					0	0	0	0	A	95564303	A	A	95564303	2	1	55	1	0	0	0	0	0	0	0	1	3271	933	33	2		2	CEP57	11	95564303	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	3477743	95564303	39442213	278	11011											
CNTN5	53942	broad.mit.edu	37	chr11	100211321	100211321	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcacttcacagtgagggctTacaatggagctggatatggg	11	10	13	7	0	2	1	2	1	0	0	2	3	2	3	0	4	2	2	0	4	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:100211321T>C	uc001pga.2	+	22	3196	c.2857T>C	c.(2857-2859)TAC>CAC	p.Y953H	CNTN5_uc001pgb.2_Missense_Mutation_p.Y879H|CNTN5_uc010ruk.1_Missense_Mutation_p.Y224H	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	953	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGTGAGGGCTTACAATGGAGC	0.448													9	26					0	0	0	0	C	100211321	C	C	100211321	3	2	55	1	0	0	0	0	1	0	0	0	3659	1754	61	5	2935	5	CNTN5	11	100211321	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	4647018	100211321	34795195	279	11012											
KIAA1377	57562	broad.mit.edu	37	chr11	101863550	101863550	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaacccatccatcaaaaatActttacaaataataccactt	20	10	0	11	0	1	0	1	0	0	0	2	0	2	0	3	0	4	0	3	0	9	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:101863550A>G	uc001pgm.2	+	10	3556	c.3286A>G	c.(3286-3288)ACT>GCT	p.T1096A	KIAA1377_uc001pgn.2_Missense_Mutation_p.T1052A|KIAA1377_uc010run.1_Missense_Mutation_p.T897A	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	1096							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CATCAAAAATACTTTACAAAT	0.259													6	27					0	0	0	0	G	101863550	G	G	101863550	3	3	55	1	0	0	0	0	1	0	0	0	8266	391	14	5	3324	5	KIAA1377	11	101863550	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	1652229	101863550	33142966	280	11013											
MMP1	4312	broad.mit.edu	37	chr11	102663349	102663349	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agattacctttgaaaaaccgGacttcatctctgtcggcaaa	13	11	7	10	2	2	2	1	1	1	1	4	3	2	3	2	2	2	1	2	2	4	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:102663349G>A	uc001phi.2	-	7	1163	c.1020C>T	c.(1018-1020)GTC>GTT	p.V340V	uc001phh.1_Intron|MMP1_uc010ruv.1_Silent_p.V274V	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	340	Hemopexin-like 2.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		TGAAAAACCGGACTTCATCTC	0.388													30	156					0	0	0	0	A	102663349	A	A	102663349	2	1	55	1	0	0	0	0	0	0	0	1	9701	1161	41	2		2	MMP1	11	102663349	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	799799	102663349	32343167	281	11014											
CADM1	23705	broad.mit.edu	37	chr11	115047259	115047259	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgcattgattatagctgTgtctgcgtctgctgcgtcat	5	17	10	9	2	4	1	1	1	3	0	4	1	4	1	0	0	5	3	0	0	2	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:115047259T>C	uc001ppi.3	-	10	1393	c.1264A>G	c.(1264-1266)ACA>GCA	p.T422A	CADM1_uc001ppf.3_Intron|CADM1_uc001ppk.3_Missense_Mutation_p.T394A|CADM1_uc001ppj.3_Missense_Mutation_p.T423A|CADM1_uc001pph.3_Missense_Mutation_p.T185A	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	422	Cytoplasmic (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		ATTATAGCTGTGTCTGCGTCT	0.463													61	145					0	0	0	0	C	115047259	C	C	115047259	3	2	55	1	0	0	0	0	1	0	0	0	2578	1696	59	5	68	5	CADM1	11	115047259	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	12383910	115047259	19959257	282	11015											
ARHGEF12	23365	broad.mit.edu	37	chr11	120350888	120350888	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcaacttgttacagtccacGgacttcaactgaatcttttg	10	14	7	10	1	2	1	1	1	1	0	3	2	3	2	1	1	4	2	1	1	4	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:120350888G>A	uc001pxl.1	+	38	3993	c.3986G>A	c.(3985-3987)CGG>CAG	p.R1329Q	ARHGEF12_uc009zat.2_Missense_Mutation_p.R1310Q|ARHGEF12_uc009zau.1_Missense_Mutation_p.R1226Q	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1329					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TACAGTCCACGGACTTCAACT	0.448			T	MLL	AML								40	166					0	0	0	0	A	120350888	A	A	120350888	3	1	55	1	0	0	0	0	1	0	0	0	897	1116	39	1	4136	1	ARHGEF12	11	120350888	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	5303629	120350888	14655628	283	11016											
ROBO4	54538	broad.mit.edu	37	chr11	124761403	124761403	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcgatgagggagccataaaaAgtgctggtgtctggaagcag	12	7	16	6	1	1	1	0	1	1	0	1	4	1	3	1	3	3	2	1	3	4	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:124761403A>G	uc001qbg.2	-	12	1880	c.1740T>C	c.(1738-1740)ACT>ACC	p.T580T	ROBO4_uc010sas.1_Silent_p.T435T|ROBO4_uc001qbh.2_Silent_p.T470T|ROBO4_uc001qbi.2_Silent_p.T138T|ROBO4_uc010sat.1_Silent_p.T138T	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	580					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		AGCCATAAAAAGTGCTGGTGT	0.622													17	55					0	0	0	0	G	124761403	G	G	124761403	2	3	55	1	0	0	0	0	0	0	0	1	13581	59	3	5		5	ROBO4	11	124761403	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	4410515	124761403	10245113	284	11017											
CDON	50937	broad.mit.edu	37	chr11	125885306	125885306	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcattgtgaaaccaggtaCagttgggggctgggttccca	8	10	15	8	0	0	1	0	1	0	0	1	1	1	1	2	4	3	5	2	4	2	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:125885306C>G	uc009zbw.2	-	7	1156	c.1028G>C	c.(1027-1029)TGT>TCT	p.C343S	CDON_uc001qdc.3_Missense_Mutation_p.C343S|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.C343S	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	343	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		AAACCAGGTACAGTTGGGGGC	0.488													11	85					0	0	0	0	G	125885306	G	G	125885306	3	3	55	1	0	0	0	0	1	0	0	0	3185	478	17	4	2822	4	CDON	11	125885306	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	1123903	125885306	9121210	285	11018											
ST14	6768	broad.mit.edu	37	chr11	130060396	130060396	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcggtgtggagctgatgcgcTtcaccacgcccggcttccct	4	9	13	15	4	1	1	1	1	0	0	2	2	2	2	3	3	2	3	3	3	0	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr11:130060396T>A	uc001qfw.2	+	7	875	c.682T>A	c.(682-684)TTC>ATC	p.F228I	ST14_uc010sca.1_Missense_Mutation_p.F38I	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	228	Extracellular (Potential).|CUB 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GCTGATGCGCTTCACCACGCC	0.697													9	67					0	0	0	0	A	130060396	A	A	130060396	3	1	55	1	0	0	0	0	1	0	0	0	15277	1609	56	5	708	5	ST14	11	130060396	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	4175090	130060396	4946120	286	11019											
RAPGEF3	10411	broad.mit.edu	37	chr12	48141546	48141546	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggagcatggagccatacagGgccacccactggctgaccag	10	5	13	13	0	0	1	0	1	0	0	0	3	0	3	4	4	3	2	4	4	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:48141546G>T	uc009zkp.2	-	13	1736	c.1296C>A	c.(1294-1296)GCC>GCA	p.A432A	RAPGEF3_uc001rpx.2_5'Flank|RAPGEF3_uc010sln.1_5'UTR|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Silent_p.A432A|RAPGEF3_uc001rpz.3_Silent_p.A474A|RAPGEF3_uc001rqa.2_5'UTR	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	432					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		AGCCATACAGGGCCACCCACT	0.657													7	45					2.74318e-10	3.09551e-10	1	0	T	48141546	T	T	48141546	2	4	55	1	0	0	0	0	0	0	0	1	13110	1219	43	4		4	RAPGEF3	12	48141546	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08		48141546	85710349	287	11020											
ANP32D	23519	broad.mit.edu	37	chr12	48866821	48866821	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaccttttcacttgcgaggTaaccaacctgaacaactact	13	10	6	12	1	1	2	1	1	0	1	1	3	1	2	3	1	6	1	3	1	5	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:48866821T>A	uc010slt.1	+	1	374	c.374T>A	c.(373-375)GTA>GAA	p.V125E		NM_012404	NP_036536	O95626	AN32D_HUMAN	acidic nuclear phosphoprotein 32D	125	LRR 5.									ovary(1)|central_nervous_system(1)	2						ACTTGCGAGGTAACCAACCTG	0.448													18	95					0	0	0	0	A	48866821	A	A	48866821	3	1	55	1	0	0	0	0	1	0	0	0	708	1638	57	5	376	5	ANP32D	12	48866821	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	725275	48866821	84985074	288	11021											
SLC4A8	9498	broad.mit.edu	37	chr12	51834519	51834519	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaagaagctgtggtggatCagggtgggaccagtacaatt	12	9	15	5	0	1	2	1	1	0	1	1	4	1	4	1	4	2	2	1	4	4	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:51834519C>T	uc001rys.1	+	2	254	c.76C>T	c.(76-78)CAG>TAG	p.Q26*	SLC4A8_uc010sni.1_5'UTR|SLC4A8_uc001rym.2_5'UTR|SLC4A8_uc001ryn.2_5'UTR|SLC4A8_uc001ryo.2_5'UTR|SLC4A8_uc001ryp.1_5'UTR|SLC4A8_uc010snj.1_Nonsense_Mutation_p.Q53*|SLC4A8_uc001ryq.3_Nonsense_Mutation_p.Q26*|SLC4A8_uc001ryr.2_Nonsense_Mutation_p.Q26*|SLC4A8_uc010snk.1_5'UTR	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	26	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TGTGGTGGATCAGGGTGGGAC	0.428													22	83					0	0	0	0	T	51834519	T	T	51834519	4	4	55	1	0	0	0	0	0	1	0	0	14723	827	29	2	82	2	SLC4A8	12	51834519	Nonsense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2967698	51834519	82017376	289	11022											
FIGNL2	401720	broad.mit.edu	37	chr12	52215791	52215791	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggggttcagggaggttcccgGctaaaactggggagcccccc	7	6	16	12	1	1	0	1	0	0	0	2	2	2	2	4	7	2	3	4	7	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:52215791G>C	uc001rzc.2	-	1	418	c.407C>G	c.(406-408)GCC>GGC	p.A136G		NM_001013690	NP_001013712	A6NMB9	FIGL2_HUMAN	fidgetin-like 2	136	Gly-rich.						ATP binding|nucleoside-triphosphatase activity				0				BRCA - Breast invasive adenocarcinoma(357;0.135)		GAGGTTCCCGGCTAAAACTGG	0.731													3	13					0	0	0	0	C	52215791	C	C	52215791	3	2	55	1	0	0	0	0	1	0	0	0	5925	1203	42	4	1558	4	FIGNL2	12	52215791	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	381272	52215791	81636104	290	11023											
MON2	23041	broad.mit.edu	37	chr12	62892803	62892803	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actgttgtttttgagaggatGgttgctgaagatgaacgaca	11	13	13	4	1	0	4	0	3	0	2	0	7	0	5	0	2	2	4	0	2	2	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:62892803G>T	uc001sre.2	+	5	931	c.540G>T	c.(538-540)ATG>ATT	p.M180I	MON2_uc009zqj.2_Missense_Mutation_p.M180I|MON2_uc010ssl.1_Missense_Mutation_p.M108I|MON2_uc010ssm.1_Missense_Mutation_p.M180I|MON2_uc010ssn.1_Missense_Mutation_p.M180I|MON2_uc001srf.2_5'Flank|MON2_uc001srd.1_Missense_Mutation_p.M72I	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	180					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TTGAGAGGATGGTTGCTGAAG	0.378													102	297					6.84326e-50	9.12434e-50	1	0	T	62892803	T	T	62892803	3	4	55	1	0	0	0	0	1	0	0	0	9753	1348	47	4	558	4	MON2	12	62892803	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	10677012	62892803	70959092	291	11024											
C12orf66	144577	broad.mit.edu	37	chr12	64588097	64588097	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggttagcttttgctgtcaacGttttcatttctgaagcagtc	7	17	9	8	1	3	1	2	1	1	0	4	1	3	1	0	1	4	5	0	1	3	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:64588097G>A	uc001srw.3	-	3	922	c.863C>T	c.(862-864)ACG>ATG	p.T288M	C12orf66_uc009zql.2_Missense_Mutation_p.T235M	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	288										ovary(1)	1						TGCTGTCAACGTTTTCATTTC	0.393													49	161					0	0	0	0	A	64588097	A	A	64588097	3	1	55	1	0	0	0	0	1	0	0	0	1715	1145	40	1	478	1	C12orf66	12	64588097	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1695294	64588097	69263798	292	11025											
GRIP1	23426	broad.mit.edu	37	chr12	66788009	66788009	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagctaatccccctttaGtgaggcttgaaatgattata	11	15	7	8	0	1	3	1	3	0	0	2	3	2	3	2	1	1	2	2	1	5	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:66788009G>C	uc001stk.2	-	16	2193	c.1952C>G	c.(1951-1953)ACT>AGT	p.T651S	GRIP1_uc010sta.1_Missense_Mutation_p.T595S|GRIP1_uc001stj.2_Missense_Mutation_p.T433S|GRIP1_uc001stl.1_Missense_Mutation_p.T543S|GRIP1_uc001stm.2_Missense_Mutation_p.T651S	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	703	PDZ 6.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		TCCCCCTTTAGTGAGGCTTGA	0.433													67	192					0	0	0	0	C	66788009	C	C	66788009	3	2	55	1	0	0	0	0	1	0	0	0	6826	1029	36	4	1314	4	GRIP1	12	66788009	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2199912	66788009	67063886	293	11026											
TRHDE	29953	broad.mit.edu	37	chr12	73056937	73056937	+	Nonsense_Mutation	SNP	G	T	T																															ggaaaatgctttaccaagacGagcttttccaatggttagga																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:73056937G>T	uc001sxa.2	+	19	3067	c.3037G>T	c.(3037-3039)GAG>TAG	p.E1013*		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	1013	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTACCAAGACGAGCTTTTCCA	0.393													21	65					4.4004e-07	4.81111e-07	1	0	T	73056937	T	T	73056937	4	4	55	1	0	0	0	0	0	1	0	0	16546	1059	37	3	3111	3	TRHDE	12	73056937	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	6268928	73056937	60794958	294	11027	25	2									
TRHDE	29953	broad.mit.edu	37	chr12	73056946	73056946	+	Missense_Mutation	SNP	C	A	A																															tttaccaagacgagcttttcCaatggttaggaaaagctcta																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:73056946C>A	uc001sxa.2	+	19	3076	c.3046C>A	c.(3046-3048)CAA>AAA	p.Q1016K		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	1016	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CGAGCTTTTCCAATGGTTAGG	0.398													18	58					1.00905e-13	1.17364e-13	1	0	A	73056946	A	A	73056946	3	1	55	1	0	0	0	0	1	0	0	0	16546	595	21	4	3120	4	TRHDE	12	73056946	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	9	73056946	60794949	295	11028	25	2									
NAV3	89795	broad.mit.edu	37	chr12	78593221	78593221	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggaacattcgcaataatGacctagtcaaaattatagat	19	10	6	6	1	1	2	1	1	0	1	2	3	1	3	1	1	1	1	1	1	9	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:78593221G>T	uc001syp.2	+	37	6798	c.6625G>T	c.(6625-6627)GAC>TAC	p.D2209Y	NAV3_uc001syo.2_Missense_Mutation_p.D2187Y|NAV3_uc010sub.1_Missense_Mutation_p.D1666Y|NAV3_uc009zsf.2_Missense_Mutation_p.D1018Y	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2209						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCGCAATAATGACCTAGTCAA	0.368										HNSCC(70;0.22)			35	111					1.42033e-22	1.78266e-22	1	0	T	78593221	T	T	78593221	3	4	55	1	0	0	0	0	1	0	0	0	10238	1290	45	2	6701	2	NAV3	12	78593221	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	5536275	78593221	55258674	296	11029											
TMTC3	160418	broad.mit.edu	37	chr12	88589095	88589095	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcattagcaccacatgaagAatatattcagcgccatttga	14	10	8	9	1	1	3	1	2	0	1	1	3	1	3	2	1	2	2	2	1	5	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:88589095A>G	uc001tau.2	+	14	2634	c.2414A>G	c.(2413-2415)GAA>GGA	p.E805G		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	806						integral to membrane	binding			skin(1)	1						CCACATGAAGAATATATTCAG	0.348													57	125					0	0	0	0	G	88589095	G	G	88589095	3	3	55	1	0	0	0	0	1	0	0	0	16328	246	9	5	2464	5	TMTC3	12	88589095	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	9995874	88589095	45262800	297	11030											
C12orf63	374467	broad.mit.edu	37	chr12	97137303	97137303	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aattcttggcctacaagaaaAgcatttaaaggcagacatca	17	9	7	8	0	2	2	1	0	1	2	2	2	2	2	1	2	2	2	1	2	7	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:97137303A>G	uc001tet.1	+	20	2696	c.2618A>G	c.(2617-2619)AAG>AGG	p.K873R		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	873										skin(6)|ovary(1)	7						CTACAAGAAAAGCATTTAAAG	0.433													3	135					0	0	0	0	G	97137303	G	G	97137303	3	3	55	1	0	0	0	0	1	0	0	0	1712	72	3	5	2692	5	C12orf63	12	97137303	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	8548208	97137303	36714592	298	11031											
ANKS1B	56899	broad.mit.edu	37	chr12	99194841	99194842	+	Missense_Mutation	DNP	GG	TT	TT																															tgctgccagtactgtaccggGgtagaggctgtggcttcatt																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:99194841_99194842GG>TT	uc001tge.1	-	20	3545_3546	c.3128_3129CC>AA	c.(3127-3129)ACC>AAA	p.T1043K	ANKS1B_uc001tgf.1_Missense_Mutation_p.T559K|ANKS1B_uc001tgk.2_Missense_Mutation_p.T340K|ANKS1B_uc010svd.1_Missense_Mutation_p.T49K|ANKS1B_uc001tgd.1_Missense_Mutation_p.T209K|ANKS1B_uc009ztq.2_5'UTR|ANKS1B_uc010sve.1_Missense_Mutation_p.T73K|ANKS1B_uc001tgh.3_Missense_Mutation_p.T49K|ANKS1B_uc001tgi.2_Missense_Mutation_p.T293K|ANKS1B_uc009ztr.2_Missense_Mutation_p.T233K|ANKS1B_uc001tgj.2_Missense_Mutation_p.T209K|ANKS1B_uc009ztp.2_Missense_Mutation_p.T74K|ANKS1B_uc010svf.1_Missense_Mutation_p.T73K|ANKS1B_uc001tgg.3_Missense_Mutation_p.T141K|ANKS1B_uc010svg.1_Missense_Mutation_p.T178K|ANKS1B_uc009zts.1_Missense_Mutation_p.T269K	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	1043						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		ACTGTACCGGGGTAGAGGCTGT	0.46													7	14					0	0	0	0	TT	99194842	TT	TT	99194841	3	4	55	1	0	0	0	0	1	0	0	0	689	1219	43	4	760	4	ANKS1B	12	99194841	Missense_Mutation	DNP	GG	TCGA-CN-5356-01A-01D-1434-08	2057538	99194841	34657054	299	11032											
MYBPC1	4604	broad.mit.edu	37	chr12	102043145	102043145	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggagcaacaaaggctgatgCtgcagaatattcagtaatga	15	8	12	6	0	1	3	1	2	0	1	1	4	1	4	0	2	4	5	0	2	5	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:102043145C>A	uc001tii.2	+	13	1331	c.1229C>A	c.(1228-1230)GCT>GAT	p.A410D	MYBPC1_uc001tif.1_Missense_Mutation_p.A423D|MYBPC1_uc001tig.2_Missense_Mutation_p.A435D|MYBPC1_uc010svq.1_Missense_Mutation_p.A397D|MYBPC1_uc001tih.2_Missense_Mutation_p.A435D|MYBPC1_uc001tij.2_Missense_Mutation_p.A410D|MYBPC1_uc010svr.1_Missense_Mutation_p.A410D|MYBPC1_uc010svs.1_Missense_Mutation_p.A410D|MYBPC1_uc010svt.1_Missense_Mutation_p.A398D|MYBPC1_uc010svu.1_Missense_Mutation_p.A391D|MYBPC1_uc001tik.2_Missense_Mutation_p.A384D	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	410	Ig-like C2-type 3.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						AAGGCTGATGCTGCAGAATAT	0.393													26	176					1.56442e-22	1.95851e-22	1	0	A	102043145	A	A	102043145	3	1	55	1	0	0	0	0	1	0	0	0	10064	797	28	4	1362	4	MYBPC1	12	102043145	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2848304	102043145	31808750	300	11033											
CUX2	23316	broad.mit.edu	37	chr12	111747976	111747976	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagccccgggcagcccctgCtgggccccagcttggggcct	3	5	14	19	1	0	0	0	0	0	0	0	0	0	0	8	4	4	3	8	4	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:111747976C>A	uc001tsa.1	+	15	1543	c.1390C>A	c.(1390-1392)CTG>ATG	p.L464M		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	464	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCAGCCCCTGCTGGGCCCCAG	0.687													7	18					0.000274275	0.000288341	1	0	A	111747976	A	A	111747976	3	1	55	1	0	0	0	0	1	0	0	0	4082	796	28	4	1448	4	CUX2	12	111747976	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	9704831	111747976	22103919	301	11034											
TPCN1	53373	broad.mit.edu	37	chr12	113730845	113730845	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctcggatgtcaccaggctGctggagaccctctcccagat	7	9	10	15	1	2	2	1	0	1	2	5	4	3	3	4	3	1	2	4	3	0	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:113730845G>T	uc001tuw.2	+	26	2517	c.2220G>T	c.(2218-2220)CTG>CTT	p.L740L	TPCN1_uc001tux.2_Silent_p.L812L|TPCN1_uc010syu.1_5'Flank	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	740	Cytoplasmic (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						TCACCAGGCTGCTGGAGACCC	0.612													12	40					5.50884e-06	5.91779e-06	1	0	T	113730845	T	T	113730845	2	4	55	1	0	0	0	0	0	0	0	1	16462	1306	46	4		4	TPCN1	12	113730845	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1982869	113730845	20121050	302	11035											
COX6A1	1337	broad.mit.edu	37	chr12	120876216	120876216	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actctcaccttcttcgtcgcGctccccggggtggcagtcag	4	10	11	16	4	3	0	2	0	2	0	7	0	4	0	3	3	0	2	3	3	0	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:120876216G>T	uc001tyf.1	+	2	164	c.138G>T	c.(136-138)GCG>GCT	p.A46A		NM_004373	NP_004364	P12074	CX6A1_HUMAN	cytochrome c oxidase subunit VIa polypeptide 1	46					respiratory electron transport chain	mitochondrial respiratory chain complex IV	cytochrome-c oxidase activity				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCTTCGTCGCGCTCCCCGGGG	0.627													38	100					2.75727e-19	3.38299e-19	1	0	T	120876216	T	T	120876216	2	4	55	1	0	0	0	0	0	0	0	1	3789	1074	38	3		3	COX6A1	12	120876216	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	7145371	120876216	12975679	303	11036											
TMEM132D	121256	broad.mit.edu	37	chr12	130184858	130184858	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcgctgcggtcgtcccaGtctctgcccatgatgtggaa	5	9	13	14	4	1	1	0	1	1	0	4	2	2	2	3	3	2	1	3	3	1	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:130184858G>T	uc009zyl.1	-	2	793	c.465C>A	c.(463-465)GAC>GAA	p.D155E		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	155	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGTCGTCCCAGTCTCTGCCCA	0.602													15	28					1.05317e-09	1.18032e-09	1	0	T	130184858	T	T	130184858	3	4	55	1	0	0	0	0	1	0	0	0	16113	1020	36	4	2866	4	TMEM132D	12	130184858	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	9308642	130184858	3667037	304	11037											
PXMP2	5827	broad.mit.edu	37	chr12	133266848	133266848	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgacctccctctccacaGtggcattttgtcagcacttg	7	13	8	13	0	2	2	1	2	1	0	4	2	3	2	3	1	1	2	3	1	0	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr12:133266848G>A	uc001ukt.2	+	2	188	c.123_splice	c.e2-1	p.S41_splice	POLE_uc001uks.1_5'Flank|POLE_uc010tbq.1_5'Flank|POLE_uc009zyu.1_5'Flank|PGAM5_uc010tbr.1_Splice_Site	NM_018663	NP_061133	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa							integral to membrane|peroxisomal membrane	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		CCTCTCCACAGTGGCATTTTG	0.517													38	113					0	0	0	0	A	133266848	A	A	133266848	5	1	55	1	0	0	0	0	0	0	1	0	12915	1043	36	4	128	4	PXMP2	12	133266848	Splice_Site	SNP	G	TCGA-CN-5356-01A-01D-1434-08	3081990	133266848	585047	305	11038											
ATP12A	479	broad.mit.edu	37	chr13	25265203	25265203	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcctcaggagttggaaatGagaagacgcccattgccatt	11	9	12	9	1	1	2	1	1	0	2	1	5	1	4	3	3	1	1	3	3	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr13:25265203G>T	uc001upp.2	+	8	1070	c.883G>T	c.(883-885)GAG>TAG	p.E295*	ATP12A_uc010aaa.2_Nonsense_Mutation_p.E301*	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	295	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AGTTGGAAATGAGAAGACGCC	0.517													36	76					2.75727e-19	3.38299e-19	1	0	T	25265203	T	T	25265203	4	4	55	1	0	0	0	0	0	1	0	0	1124	1291	45	2	931	2	ATP12A	13	25265203	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08		25265203	89904675	306	11039											
CCNA1	8900	broad.mit.edu	37	chr13	37015288	37015288	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgagtctacttgaagcagatCcattcttgaaatatcttcct	11	15	6	9	0	3	4	0	3	3	1	5	4	5	4	2	0	2	1	2	0	4	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr13:37015288C>G	uc001uvr.3	+	7	1482	c.1132C>G	c.(1132-1134)CCA>GCA	p.P378A	CCNA1_uc010teo.1_Missense_Mutation_p.P334A|CCNA1_uc010abq.2_Missense_Mutation_p.P334A|CCNA1_uc010abp.2_Missense_Mutation_p.P334A|CCNA1_uc001uvs.3_Missense_Mutation_p.P377A|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	378					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		TGAAGCAGATCCATTCTTGAA	0.398													41	70					0	0	0	0	G	37015288	G	G	37015288	3	3	55	1	0	0	0	0	1	0	0	0	2924	855	30	2	1158	2	CCNA1	13	37015288	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	11750085	37015288	78154590	307	11040											
ZIC2	7546	broad.mit.edu	37	chr13	100637292	100637292	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acatgcacgtccacacctccGataagccctatctctgcaag	11	8	6	16	2	1	0	0	0	1	0	4	1	3	0	4	0	3	2	4	0	3	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr13:100637292G>A	uc001von.2	+	2	1168	c.1168G>A	c.(1168-1170)GAT>AAT	p.D390N		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	390					brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCACACCTCCGATAAGCCCTA	0.627													47	48					0	0	0	0	A	100637292	A	A	100637292	3	1	55	1	0	0	0	0	1	0	0	0	17746	1058	37	1	1174	1	ZIC2	13	100637292	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	63622004	100637292	14532586	308	11041											
OR11H12	440153	broad.mit.edu	37	chr14	19377681	19377681	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtaaatgaatttatactcCaaggtttcacttgtgagtgg	11	16	9	5	0	1	2	1	2	0	0	2	2	2	2	1	2	1	2	1	2	6	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:19377681C>A	uc010tkp.1	+	1	88	c.88C>A	c.(88-90)CAA>AAA	p.Q30K		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	30	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTTATACTCCAAGGTTTCAC	0.413													70	187					7.07328e-35	9.18221e-35	1	0	A	19377681	A	A	19377681	3	1	55	1	0	0	0	0	1	0	0	0	10981	595	21	4	90	4	OR11H12	14	19377681	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08		19377681	87971859	309	11042											
POTEG	404785	broad.mit.edu	37	chr14	19553736	19553736	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtggtgctgccactgcttccCctgctgcagggggagcggca	4	8	16	13	1	0	0	0	0	0	0	1	1	1	1	3	4	6	5	3	4	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:19553736C>A	uc001vuz.1	+	1	372	c.320C>A	c.(319-321)CCC>CAC	p.P107H	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	107										ovary(1)	1						CACTGCTTCCCCTGCTGCAGG	0.602													23	591					3.03874e-20	3.7754e-20	1	0	A	19553736	A	A	19553736	3	1	55	1	0	0	0	0	1	0	0	0	12321	623	22	4	322	4	POTEG	14	19553736	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	176055	19553736	87795804	310	11043											
OR4L1	122742	broad.mit.edu	37	chr14	20528872	20528872	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttacattgtcatcctggtCagtgtaccaaaaaaatcatc	13	13	5	10	0	4	0	3	0	1	0	6	0	5	0	2	1	2	1	2	1	5	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:20528872C>A	uc001vwn.1	+	1	669	c.669C>A	c.(667-669)GTC>GTA	p.V223V		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TCATCCTGGTCAGTGTACCAA	0.438													58	180					2.41709e-19	2.98047e-19	1	0	A	20528872	A	A	20528872	2	1	55	1	0	0	0	0	0	0	0	1	11128	813	29	2		2	OR4L1	14	20528872	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	975136	20528872	86820668	311	11044											
CHD8	57680	broad.mit.edu	37	chr14	21863125	21863125	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcttgaaggctgcttcacaaCgccgccttcgccggtcccca	6	8	10	17	4	1	1	1	1	0	0	3	1	2	1	5	2	2	3	5	2	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:21863125C>A	uc001was.1	-	30	4593	c.4499G>T	c.(4498-4500)CGT>CTT	p.R1500L	CHD8_uc001war.1_Missense_Mutation_p.R1396L|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1779					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TGCTTCACAACGCCGCCTTCG	0.498													30	55					3.99451e-17	4.78175e-17	1	0	A	21863125	A	A	21863125	3	1	55	1	0	0	0	0	1	0	0	0	3346	536	19	3	2445	3	CHD8	14	21863125	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	1334253	21863125	85486415	312	11045											
CMTM5	116173	broad.mit.edu	37	chr14	23846490	23846490	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gctcgagatcgccgggaccgGcaccctgaggagggggtagt	7	5	18	11	4	0	2	0	1	0	1	2	5	0	4	3	5	0	3	3	5	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:23846490G>A	uc010akm.2	+	1	474	c.30G>A	c.(28-30)CGG>CGA	p.R10R	CMTM5_uc001wjs.2_Silent_p.R10R|CMTM5_uc001wjt.2_Silent_p.R10R|CMTM5_uc010akn.2_Silent_p.R10R|CMTM5_uc001wju.2_Silent_p.R10R|CMTM5_uc010ako.2_RNA	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	10					chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		GCCGGGACCGGCACCCTGAGG	0.602													4	161					0	0	0	0	A	23846490	A	A	23846490	2	1	55	1	0	0	0	0	0	0	0	1	3601	1190	42	4		4	CMTM5	14	23846490	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1983365	23846490	83503050	313	11046											
MIPOL1	145282	broad.mit.edu	37	chr14	37777652	37777652	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatagaatctacaagaccaaGgaatgtaaaatgagaataac	21	7	8	5	0	1	3	0	1	1	3	1	6	1	4	1	1	2	1	1	1	10	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:37777652G>A	uc001wuc.2	+	10	1259	c.756G>A	c.(754-756)AAG>AAA	p.K252K	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Silent_p.K221K|MIPOL1_uc001wud.2_Silent_p.K252K|MIPOL1_uc010ams.2_Silent_p.K252K|MIPOL1_uc001wue.2_Silent_p.K221K|MIPOL1_uc010amt.2_Silent_p.K71K	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	252										ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		ACAAGACCAAGGAATGTAAAA	0.368													46	138					0	0	0	0	A	37777652	A	A	37777652	2	1	55	1	0	0	0	0	0	0	0	1	9646	991	35	4		4	MIPOL1	14	37777652	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	13931162	37777652	69571888	314	11047											
KTN1	3895	broad.mit.edu	37	chr14	56114744	56114744	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaaatttataatttcagcAttcaagaaaaagatgagaag	20	11	6	4	0	2	3	2	1	0	3	2	4	2	3	0	0	2	1	0	0	8	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:56114744A>C	uc001xcb.2	+	21	2511	c.2209A>C	c.(2209-2211)ATT>CTT	p.I737L	KTN1_uc001xce.2_Missense_Mutation_p.I737L|KTN1_uc001xcc.2_Missense_Mutation_p.I737L|KTN1_uc001xcd.2_Missense_Mutation_p.I737L|KTN1_uc010trb.1_Missense_Mutation_p.I737L|KTN1_uc001xcf.1_Missense_Mutation_p.I737L|KTN1_uc010aoq.2_Missense_Mutation_p.I32L	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	737	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						TAATTTCAGCATTCAAGAAAA	0.229			T	RET	papillary thryoid								10	63					0	0	0	0	C	56114744	C	C	56114744	3	2	55	1	0	0	0	0	1	0	0	0	8625	231	8	5	2283	5	KTN1	14	56114744	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	18337092	56114744	51234796	315	11048											
SYNE2	23224	broad.mit.edu	37	chr14	64630120	64630120	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	catccctttttcttctgcagGagctgcagcatgatgtgcag	7	13	10	11	0	2	1	0	1	2	0	3	2	3	2	1	1	5	5	1	1	0	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:64630120G>C	uc001xgm.2	+	89	16530	c.16300G>C	c.(16300-16302)GAG>CAG	p.E5434Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E5434Q|SYNE2_uc010apy.2_Missense_Mutation_p.E1819Q|SYNE2_uc001xgn.2_Missense_Mutation_p.E396Q|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5434	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCTTCTGCAGGAGCTGCAGCA	0.493													25	86					0	0	0	0	C	64630120	C	C	64630120	3	2	55	1	0	0	0	0	1	0	0	0	15512	1188	41	2	16650	2	SYNE2	14	64630120	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	8515376	64630120	42719420	316	11049											
C14orf166B	145497	broad.mit.edu	37	chr14	77327047	77327047	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcacagaacgtgctggtGtccgagcagttcatgaaaac	11	9	11	10	2	2	2	2	1	0	1	3	3	3	2	1	1	4	3	1	1	3	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:77327047G>T	uc001xsx.2	+	11	1230	c.1116G>T	c.(1114-1116)GTG>GTT	p.V372V	C14orf166B_uc010asn.1_Silent_p.V132V|C14orf166B_uc001xsw.2_RNA	NM_194287	NP_919263	Q0VAA2	CN16B_HUMAN	hypothetical protein LOC145497	372											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		ACGTGCTGGTGTCCGAGCAGT	0.577													16	73					1.02788e-11	1.17883e-11	1	0	T	77327047	T	T	77327047	2	4	55	1	0	0	0	0	0	0	0	1	1763	1364	48	4		4	C14orf166B	14	77327047	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	12696927	77327047	30022493	317	11050											
PRIMA1	145270	broad.mit.edu	37	chr14	94187810	94187810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacaccactgcgttgttcaCgtctactcctttgttgctct	5	16	6	14	2	4	0	2	0	2	0	5	0	5	0	2	0	3	4	2	0	1	5	rs140016687		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:94187810C>T	uc001ybw.1	-	5	484	c.442G>A	c.(442-444)GTG>ATG	p.V148M	PRIMA1_uc001ybx.1_RNA	NM_178013	NP_821092	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1 precursor	148	Cytoplasmic (Potential).				neurotransmitter catabolic process	cell junction|integral to membrane|synapse				large_intestine(1)|skin(1)	2		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		GCGTTGTTCACGTCTACTCCT	0.572													13	55					0	0	0	0	T	94187810	T	T	94187810	3	4	55	1	0	0	0	0	1	0	0	0	12554	536	19	1	23	1	PRIMA1	14	94187810	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	16860763	94187810	13161730	318	11051											
SERPINA4	5267	broad.mit.edu	37	chr14	95033433	95033433	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcactggtatcttcatgacaGatacttgccctgctcggtgc	7	13	9	12	1	3	2	2	1	1	1	4	2	3	2	1	2	4	2	1	2	2	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr14:95033433G>A	uc001ydk.2	+	3	842	c.776G>A	c.(775-777)AGA>AAA	p.R259K	SERPINA4_uc010avd.2_Missense_Mutation_p.R296K|SERPINA4_uc001ydl.2_Missense_Mutation_p.R259K	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	259					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		CTTCATGACAGATACTTGCCC	0.488													30	74					0	0	0	0	A	95033433	A	A	95033433	3	1	55	1	0	0	0	0	1	0	0	0	14156	942	33	2	782	2	SERPINA4	14	95033433	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	845623	95033433	12316107	319	11052											
MKRN3	7681	broad.mit.edu	37	chr15	23811560	23811561	+	Missense_Mutation	DNP	CC	AA	AA																															ttgagtttgttccagggcagCcctaccggggccgctgggtt																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:23811560_23811561CC>AA	uc001ywh.3	+	1	1107_1108	c.631_632CC>AA	c.(631-633)CCC>AAC	p.P211N	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.P211N	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	211						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TCCAGGGCAGCCCTACCGGGGC	0.599													12	46					0	0	0	0	AA	23811561	AA	AA	23811560	3	1	55	1	0	0	0	0	1	0	0	0	9661	739	26	4	633	4	MKRN3	15	23811560	Missense_Mutation	DNP	CC	TCGA-CN-5356-01A-01D-1434-08		23811560	78719832	320	11053											
GABRB3	2562	broad.mit.edu	37	chr15	26806266	26806266	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctttgacataggggattttgGgcaaggtctcccgaaggtgg	8	11	15	7	1	1	1	0	1	1	0	2	3	1	2	1	6	0	1	1	6	3	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:26806266G>T	uc001zaz.2	-	8	1035	c.893C>A	c.(892-894)CCC>CAC	p.P298H	GABRB3_uc010uae.1_Missense_Mutation_p.P213H|GABRB3_uc001zba.2_Missense_Mutation_p.P298H|GABRB3_uc001zbb.2_Missense_Mutation_p.P354H	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	298					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGGGATTTTGGGCAAGGTCTC	0.468													34	125					2.42023e-17	2.91138e-17	1	0	T	26806266	T	T	26806266	3	4	55	1	0	0	0	0	1	0	0	0	6202	1232	43	4	536	4	GABRB3	15	26806266	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2994706	26806266	75725126	321	11054											
FSIP1	161835	broad.mit.edu	37	chr15	39909940	39909940	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttcgccaagcctcacctgcTattgtattctctggagaact	8	13	8	12	1	2	1	1	0	1	1	4	2	2	1	3	1	3	3	3	1	4	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:39909940T>C	uc001zki.2	-	11	1913	c.1695A>G	c.(1693-1695)ATA>ATG	p.I565M		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	565										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		CCTCACCTGCTATTGTATTCT	0.388													60	143					0	0	0	0	C	39909940	C	C	39909940	3	2	55	1	0	0	0	0	1	0	0	0	6108	1512	53	5	58	5	FSIP1	15	39909940	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	13103674	39909940	62621452	322	11055											
CATSPER2	117155	broad.mit.edu	37	chr15	43927951	43927951	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatctgccgcttgaacatGtcagctttgagctgaacctc	9	12	9	11	1	2	4	1	4	1	0	3	4	2	4	2	0	5	3	2	0	2	2	rs144799666		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:43927951G>A	uc001zsh.2	-	9	1310	c.1095C>T	c.(1093-1095)GAC>GAT	p.D365D	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Silent_p.D365D|CATSPER2_uc001zsj.2_Silent_p.D365D	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	365	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GCTTGAACATGTCAGCTTTGA	0.488													21	45					0	0	0	0	A	43927951	A	A	43927951	2	1	55	1	0	0	0	0	0	0	0	1	2700	1368	48	4		4	CATSPER2	15	43927951	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4018011	43927951	58603441	323	11056											
SPG11	80208	broad.mit.edu	37	chr15	44941067	44941067	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcatttaattctgttacctcTagtgcatgtatgggaattga	10	16	9	6	0	2	1	0	1	2	0	2	2	2	2	1	1	2	4	1	1	5	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:44941067T>A	uc001ztx.2	-	7	1630	c.1599A>T	c.(1597-1599)CTA>CTT	p.L533L	SPG11_uc010ueh.1_Silent_p.L533L|SPG11_uc010uei.1_Silent_p.L533L|SPG11_uc001zua.1_Silent_p.L533L	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	533	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CTGTTACCTCTAGTGCATGTA	0.363													47	108					0	0	0	0	A	44941067	A	A	44941067	2	1	55	1	0	0	0	0	0	0	0	1	15107	1509	53	5		5	SPG11	15	44941067	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	1013116	44941067	57590325	324	11057											
SLC28A2	9153	broad.mit.edu	37	chr15	45557355	45557355	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactggtcaaggatgtcttTgcttttcaggtgatacctat	9	15	9	8	0	3	1	2	1	1	0	3	2	3	2	1	3	2	1	1	3	3	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:45557355T>A	uc001zva.2	+	8	836	c.771T>A	c.(769-771)TTT>TTA	p.F257L		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	257					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		AGGATGTCTTTGCTTTTCAGG	0.438													9	246					0	0	0	0	A	45557355	A	A	45557355	3	1	55	1	0	0	0	0	1	0	0	0	14596	1809	63	5	797	5	SLC28A2	15	45557355	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	616288	45557355	56974037	325	11058											
ALDH1A2	8854	broad.mit.edu	37	chr15	58302916	58302916	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcgaaaggttttgatgacgcCctgcaaatccacataaaaag	15	9	8	9	2	0	2	0	2	0	0	2	3	1	2	2	1	1	2	2	1	5	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:58302916C>T	uc002aex.2	-	4	482	c.424G>A	c.(424-426)GGC>AGC	p.G142S	ALDH1A2_uc002aey.2_Missense_Mutation_p.G142S|ALDH1A2_uc010ugv.1_Missense_Mutation_p.G121S|ALDH1A2_uc010ugw.1_Missense_Mutation_p.G113S|ALDH1A2_uc002aew.2_Missense_Mutation_p.G46S	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	142					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTGATGACGCCCTGCAAATCC	0.433													36	95					0	0	0	0	T	58302916	T	T	58302916	3	4	55	1	0	0	0	0	1	0	0	0	491	623	22	4	1172	4	ALDH1A2	15	58302916	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	12745561	58302916	44228476	326	11059											
WDR73	84942	broad.mit.edu	37	chr15	85197483	85197483	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaagcgcaaggattccaccAgccagtcgtccccaggatcc	11	5	9	16	2	0	0	0	0	0	0	4	2	3	2	6	2	2	1	6	2	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:85197483A>T	uc002bkw.2	-	1	39	c.23T>A	c.(22-24)CTG>CAG	p.L8Q	WDR73_uc002bkv.2_5'Flank|WDR73_uc002bkx.2_RNA|WDR73_uc010upa.1_Missense_Mutation_p.L8Q	NM_032856	NP_116245	Q6P4I2	WDR73_HUMAN	WD repeat domain 73	8											0						GGATTCCACCAGCCAGTCGTC	0.677													34	136					0	0	0	0	T	85197483	T	T	85197483	3	4	55	1	0	0	0	0	1	0	0	0	17391	188	7	5	1145	5	WDR73	15	85197483	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	26894567	85197483	17333909	327	11060											
NTRK3	4916	broad.mit.edu	37	chr15	88472661	88472661	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatcattgcatctggcccatGggccctgcaagagcatgggg	8	8	14	11	0	2	1	1	0	1	1	2	2	2	1	2	4	3	3	2	4	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr15:88472661G>A	uc002bme.1	-	16	2056	c.1894C>T	c.(1894-1896)CAT>TAT	p.H632Y	NTRK3_uc002bmh.2_Missense_Mutation_p.H624Y|NTRK3_uc002bmf.1_Missense_Mutation_p.H632Y|NTRK3_uc010upl.1_Missense_Mutation_p.H534Y|NTRK3_uc010bnh.1_Missense_Mutation_p.H624Y	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	632	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCTGGCCCATGGGCCCTGCAA	0.488			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			10	34					0	0	0	0	A	88472661	A	A	88472661	3	1	55	1	0	0	0	0	1	0	0	0	10762	1348	47	4	641	4	NTRK3	15	88472661	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	3275178	88472661	14058731	328	11061											
HBA2	3040	broad.mit.edu	37	chr16	223546	223546	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctgcggtgcacgcctccCtggacaagttcctggcttct	4	10	10	17	2	1	0	0	0	1	0	3	1	3	1	5	3	2	3	5	3	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:223546C>A	uc002cfv.3	+	3	442	c.376C>A	c.(376-378)CTG>ATG	p.L126M	HBA2_uc002cfw.2_Intron	NM_000517	NP_000508	P69905	HBA_HUMAN	alpha 2 globin	126			L -> R (in Plasencia; family with moderate microcytosis and hypochromia).|L -> P (in Quong Sze; causes alpha- thalassemia).		hydrogen peroxide catabolic process|positive regulation of cell death|protein heterooligomerization	cytosolic small ribosomal subunit|haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity|protein binding				0		all_cancers(16;2.03e-06)|all_epithelial(16;5.16e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0138)|all_lung(18;0.0306)			Amodiaquine(DB00613)|Chloroquine(DB00608)|Iron Dextran(DB00893)|Mefloquine(DB00358)|Primaquine(DB01087)|Quinine(DB00468)	GCACGCCTCCCTGGACAAGTT	0.652											OREG0003686	type=REGULATORY REGION|Gene=SERPINB9|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	18	25					3.8784e-16	4.63149e-16	1	0	A	223546	A	A	223546	3	1	55	1	0	0	0	0	1	0	0	0	7016	680	24	4	386	4	HBA2	16	223546	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08		223546	90131207	329	11062											
UBE2I	7329	broad.mit.edu	37	chr16	1374785	1374785	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacaagccaagaagtttgcGccctcataagcagcgacctt	12	7	9	13	2	1	1	1	0	0	1	1	2	1	1	3	0	4	3	3	0	4	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:1374785G>T	uc002clc.1	+	7	572	c.468G>T	c.(466-468)GCG>GCT	p.A156A	UBE2I_uc002cld.1_Silent_p.A156A|UBE2I_uc002clf.1_Silent_p.A156A|UBE2I_uc002clg.1_Silent_p.A156A	NM_194261	NP_919237	P63279	UBC9_HUMAN	ubiquitin-conjugating enzyme E2I	156					cell division|chromosome segregation|interspecies interaction between organisms|mitosis|negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|protein sumoylation	cytoplasm|PML body|synaptonemal complex	ATP binding|enzyme binding|ubiquitin-protein ligase activity			breast(1)|skin(1)	2		Hepatocellular(780;0.00369)				AGAAGTTTGCGCCCTCATAAG	0.473													14	55					2.4624e-09	2.74716e-09	1	0	T	1374785	T	T	1374785	2	4	55	1	0	0	0	0	0	0	0	1	16927	1074	38	3		3	UBE2I	16	1374785	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1151239	1374785	88979968	330	11063											
ZNF597	146434	broad.mit.edu	37	chr16	3487033	3487033	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgggatagatgagagtgctgGcgaaagctggcactgcactt	10	8	15	8	2	0	2	0	1	0	2	0	5	0	3	0	3	3	4	0	3	2	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:3487033G>A	uc002cvd.2	-	4	850	c.666C>T	c.(664-666)CGC>CGT	p.R222R		NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	zinc finger protein 597	222	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAGTGCTGGCGAAAGCTGG	0.473													80	194					0	0	0	0	A	3487033	A	A	3487033	2	1	55	1	0	0	0	0	0	0	0	1	18094	1190	42	4		4	ZNF597	16	3487033	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2112248	3487033	86867720	331	11064											
TFAP4	7023	broad.mit.edu	37	chr16	4310219	4310219	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcacgatcaccgtggggtGgtgggtgggggccggagggg	4	6	24	7	3	1	0	1	0	0	0	1	2	1	1	2	10	0	1	2	10	0	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:4310219G>A	uc010uxg.1	-	6	948	c.694C>T	c.(694-696)CAC>TAC	p.H232Y		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	232	Pro-rich.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						ACCGTGGGGTGGTGGGTGGGG	0.617													26	39					0	0	0	0	A	4310219	A	A	4310219	3	1	55	1	0	0	0	0	1	0	0	0	15858	1348	47	4	330	4	TFAP4	16	4310219	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	823186	4310219	86044534	332	11065											
GRIN2A	2903	broad.mit.edu	37	chr16	9892263	9892263	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtcaccagcttgcagccttCatccctcccagccttgtaat	7	11	7	16	0	2	0	2	0	0	0	4	0	4	0	5	1	4	3	5	1	1	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:9892263C>G	uc002czo.3	-	11	2775	c.2227G>C	c.(2227-2229)GAA>CAA	p.E743Q	GRIN2A_uc010uym.1_Missense_Mutation_p.E743Q|GRIN2A_uc010uyn.1_Missense_Mutation_p.E586Q|GRIN2A_uc002czr.3_Missense_Mutation_p.E743Q	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	743	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGCAGCCTTCATCCCTCCCA	0.537													23	87					0	0	0	0	G	9892263	G	G	9892263	3	3	55	1	0	0	0	0	1	0	0	0	6818	835	29	2	2179	2	GRIN2A	16	9892263	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	5582044	9892263	80462490	333	11066											
ACSM1	116285	broad.mit.edu	37	chr16	20682863	20682863	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctttcctaccttcctgggaAggagggttgtaaggccaacc	8	11	11	11	0	1	0	0	0	1	0	3	2	3	2	5	4	2	2	5	4	4	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:20682863A>G	uc002dhm.1	-	4	810	c.742T>C	c.(742-744)TTC>CTC	p.F248L	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Missense_Mutation_p.F248L	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	248					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						CTTCCTGGGAAGGAGGGTTGT	0.438													36	76					0	0	0	0	G	20682863	G	G	20682863	3	3	55	1	0	0	0	0	1	0	0	0	182	72	3	5	1031	5	ACSM1	16	20682863	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	10790600	20682863	69671890	334	11067											
EEF2K	29904	broad.mit.edu	37	chr16	22271842	22271842	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaccatgatcatctagacAaccaccgggtgagtgtgaag	13	7	12	9	1	2	5	1	3	1	2	2	6	2	5	3	1	1	0	3	1	3	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:22271842A>T	uc002dki.2	+	11	1776	c.1291A>T	c.(1291-1293)AAC>TAC	p.N431Y	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	431					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		TCATCTAGACAACCACCGGGT	0.547													55	193					0	0	0	0	T	22271842	T	T	22271842	3	4	55	1	0	0	0	0	1	0	0	0	4952	130	5	5	1329	5	EEF2K	16	22271842	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	1588979	22271842	68082911	335	11068											
ITGAX	3687	broad.mit.edu	37	chr16	31373420	31373420	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gccccgttctgggggctgtgGggagcttcacctggtctgga	3	10	17	11	1	3	0	1	0	2	0	3	2	3	2	3	6	1	3	3	6	0	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr16:31373420G>A	uc002ebu.1	+	11	1178	c.1111G>A	c.(1111-1113)GGG>AGG	p.G371R	ITGAX_uc002ebt.2_Missense_Mutation_p.G371R|ITGAX_uc010vfk.1_Missense_Mutation_p.G21R	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	371	FG-GAP 3.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGGGGCTGTGGGGAGCTTCAC	0.567													82	252					0	0	0	0	A	31373420	A	A	31373420	3	1	55	1	0	0	0	0	1	0	0	0	7928	1232	43	4	1153	4	ITGAX	16	31373420	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	9101578	31373420	58981333	336	11069											
TSR1	55720	broad.mit.edu	37	chr17	2238908	2238908	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagtgtactgttccagtgtcCctatcttgaagcagctgcat	9	13	9	10	0	1	1	0	1	1	0	3	1	3	1	2	0	4	5	2	0	4	4	rs139241652		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:2238908C>T	uc002fuj.2	-	3	1275	c.318G>A	c.(316-318)AGG>AGA	p.R106R	SGSM2_uc002fum.3_5'Flank|SGSM2_uc010vqw.1_5'Flank|SGSM2_uc002fun.3_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	106					ribosome assembly	nucleolus	protein binding			ovary(1)	1						TTCCAGTGTCCCTATCTTGAA	0.542													4	153					0	0	0	0	T	2238908	T	T	2238908	2	4	55	1	0	0	0	0	0	0	0	1	16731	622	22	4		4	TSR1	17	2238908	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08		2238908	78956302	337	11070											
OR1D2	4991	broad.mit.edu	37	chr17	2995854	2995854	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cggataggacccaacacaagGaaaggagtaagatacagagc	18	3	12	8	1	0	2	0	0	0	2	0	6	0	6	1	4	3	1	1	4	6	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:2995854G>A	uc010vrb.1	-	1	437	c.437C>T	c.(436-438)TCC>TTC	p.S146F		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	146	Helical; Name=4; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CCAACACAAGGAAAGGAGTAA	0.522													38	50					0	0	0	0	A	2995854	A	A	2995854	3	1	55	1	0	0	0	0	1	0	0	0	11007	1174	41	2	504	2	OR1D2	17	2995854	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	756946	2995854	78199356	338	11071											
ATP2A3	489	broad.mit.edu	37	chr17	3844430	3844430	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttgcccgccacgtcttcCgtgtccccaaagatgccaag	7	8	9	17	3	1	1	0	0	1	1	3	1	3	1	7	0	2	0	7	0	2	2	rs139395876		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:3844430C>T	uc002fxb.1	-	14	2086	c.1935G>A	c.(1933-1935)ACG>ACA	p.T645T	ATP2A3_uc002fwx.1_Silent_p.T645T|ATP2A3_uc002fwy.1_Silent_p.T645T|ATP2A3_uc002fwz.1_Silent_p.T645T|ATP2A3_uc002fxa.1_Silent_p.T645T|ATP2A3_uc002fxc.1_Silent_p.T645T|ATP2A3_uc002fxd.1_Silent_p.T645T	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	645	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CCACGTCTTCCGTGTCCCCAA	0.682													14	86					0	0	0	0	T	3844430	T	T	3844430	2	4	55	1	0	0	0	0	0	0	0	1	1140	639	23	1		1	ATP2A3	17	3844430	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	848576	3844430	77350780	339	11072											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	12	6	8	15	2	1	0	1	0	0	0	3	1	3	1	3	2	2	4	3	2	2	1	rs28934576	by1000genomes	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			34	36					0	0	0	0	T	7577120	T	T	7577120	3	4	55	1	0	0	0	0	1	0	0	0	16448	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3732690	7577120	73618090	340	11073											
MYH2	4620	broad.mit.edu	37	chr17	10429179	10429179	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcagctgcctgcagccgcTgggccagcttcttccttgaa	5	10	10	16	1	2	1	1	1	1	0	3	1	3	1	5	1	5	4	5	1	1	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:10429179T>A	uc010coi.2	-	31	4330	c.4202A>T	c.(4201-4203)CAG>CTG	p.Q1401L	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.Q1401L|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1401	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTGCAGCCGCTGGGCCAGCTT	0.473													14	70					0	0	0	0	A	10429179	A	A	10429179	3	1	55	1	0	0	0	0	1	0	0	0	10088	1580	55	5	1663	5	MYH2	17	10429179	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	2852059	10429179	70766031	341	11074											
DNAH9	1770	broad.mit.edu	37	chr17	11515024	11515024	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaataacggtgaggggcatGgccaagctcctggacaagct	12	6	13	10	1	0	1	0	1	0	0	1	2	1	2	2	5	3	3	2	5	4	1	rs141141277		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:11515024G>T	uc002gne.2	+	4	899	c.831G>T	c.(829-831)ATG>ATT	p.M277I	DNAH9_uc002gnd.1_Missense_Mutation_p.M277I	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	277	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGAGGGGCATGGCCAAGCTCC	0.443													87	66					1.72036e-36	2.25111e-36	1	0	T	11515024	T	T	11515024	3	4	55	1	0	0	0	0	1	0	0	0	4630	1348	47	4	845	4	DNAH9	17	11515024	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1085845	11515024	69680186	342	11075											
MAP2K3	5606	broad.mit.edu	37	chr17	21207776	21207776	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttatcaacaaggagggcCatgtgaagatgtgtgacttt	11	12	11	7	0	1	3	1	2	0	1	2	4	2	4	2	2	1	0	2	2	4	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:21207776C>T	uc002gys.2	+	8	872	c.607C>T	c.(607-609)CAT>TAT	p.H203Y	MAP2K3_uc002gyt.2_Missense_Mutation_p.H174Y|MAP2K3_uc002gyu.2_Missense_Mutation_p.H174Y	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	203	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CAAGGAGGGCCATGTGAAGAT	0.582													12	108					0	0	0	0	T	21207776	T	T	21207776	3	4	55	1	0	0	0	0	1	0	0	0	9291	594	21	4	637	4	MAP2K3	17	21207776	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	9692752	21207776	59987434	343	11076											
C17orf63	55731	broad.mit.edu	37	chr17	27085474	27085474	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctggcttgccactggaccGcccccggtccctgctcggta	3	10	11	17	3	1	0	0	0	1	0	3	1	2	1	5	4	2	3	5	4	1	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:27085474G>T	uc002hct.1	-	3	1770	c.1503C>A	c.(1501-1503)GGC>GGA	p.G501G	C17orf63_uc010wax.1_Silent_p.G501G|C17orf63_uc010way.1_Silent_p.G501G|C17orf63_uc002hcw.2_Silent_p.G373G	NM_018182	NP_060652	Q8WU58	CQ063_HUMAN	hypothetical protein LOC55731	501										ovary(1)	1	all_epithelial(6;5.06e-20)|Lung NSC(42;0.01)		Epithelial(11;3.38e-06)|all cancers(11;2.46e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.104)			CCACTGGACCGCCCCCGGTCC	0.632													34	67					6.00712e-18	7.29754e-18	1	0	T	27085474	T	T	27085474	2	4	55	1	0	0	0	0	0	0	0	1	1878	1074	38	3		3	C17orf63	17	27085474	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	5877698	27085474	54109736	344	11077											
GPR179	440435	broad.mit.edu	37	chr17	36483635	36483635	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcagtagtgaattcttcTgtgtctgcagctggagcttt	6	17	10	8	0	5	1	1	1	4	0	5	2	5	2	0	1	3	4	0	1	2	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:36483635T>A	uc002hpz.2	-	11	5838	c.5817A>T	c.(5815-5817)ACA>ACT	p.T1939T		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1939	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TGAATTCTTCTGTGTCTGCAG	0.498													28	97					0	0	0	0	A	36483635	A	A	36483635	2	1	55	1	0	0	0	0	0	0	0	1	6712	1567	55	5		5	GPR179	17	36483635	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	9398161	36483635	44711575	345	11078											
ERBB2	2064	broad.mit.edu	37	chr17	37879629	37879629	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgctggtcgtggtcttgggGgtggtctttgggatcctcat	2	15	16	8	1	3	0	1	0	2	0	5	1	4	1	1	6	1	1	1	6	0	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:37879629G>T	uc002hso.2	+	17	2242	c.2004G>T	c.(2002-2004)GGG>GGT	p.G668G	ERBB2_uc002hsm.2_Silent_p.G638G|ERBB2_uc010cwa.2_Silent_p.G653G|ERBB2_uc002hsp.2_Silent_p.G471G|ERBB2_uc010cwb.2_Silent_p.G668G|ERBB2_uc010wek.1_Silent_p.G392G	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	668	Helical; (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TGGTCTTGGGGGTGGTCTTTG	0.607		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			49	147					3.21987e-24	4.08293e-24	1	0	T	37879629	T	T	37879629	2	4	55	1	0	0	0	0	0	0	0	1	5230	1219	43	4		4	ERBB2	17	37879629	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1395994	37879629	43315581	346	11079											
KRTAP4-8	728224	broad.mit.edu	37	chr17	39253804	39253804	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaagaggaggcgcagcacAcggggcgggggcaggtggag	10	1	22	8	3	0	1	0	0	0	1	0	3	0	3	0	8	2	4	0	8	1	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:39253804A>T	uc010wfo.1	-	1	572	c.533T>A	c.(532-534)GTG>GAG	p.V178E		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	178						keratin filament					0						GGCGCAGCACACGGGGCGGGG	0.547													2	2					0	0	0	0	T	39253804	T	T	39253804	3	4	55	1	0	0	0	0	1	0	0	0	8596	159	6	5	28	5	KRTAP4-8	17	39253804	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	1374175	39253804	41941406	347	11080											
KRT33A	3883	broad.mit.edu	37	chr17	39502482	39502482	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgtggcgcaggggttggaGgggagcctgtgggcagaaaa	8	7	21	5	1	0	1	0	0	0	1	0	3	0	3	1	7	1	4	1	7	2	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:39502482G>A	uc002hwk.1	-	7	1141	c.1104C>T	c.(1102-1104)CCC>CCT	p.P368P		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	368	Tail.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				AGGGGTTGGAGGGGAGCCTGT	0.488													12	129					0	0	0	0	A	39502482	A	A	39502482	2	1	55	1	0	0	0	0	0	0	0	1	8508	987	35	4		4	KRT33A	17	39502482	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	248678	39502482	41692728	348	11081											
CNTD1	124817	broad.mit.edu	37	chr17	40951132	40951132	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctccctcgttgactttcAgtttggagttgtcgccacag	5	13	11	12	2	1	1	1	1	0	0	4	2	2	2	3	2	0	3	3	2	0	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:40951132A>G	uc002ibm.3	+	1	279	c.47A>G	c.(46-48)CAG>CGG	p.Q16R	CCDC56_uc010wgz.1_5'Flank|CCDC56_uc002ibl.2_5'Flank|CNTD1_uc010wha.1_Intron	NM_173478	NP_775749	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	16										central_nervous_system(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GTTGACTTTCAGTTTGGAGTT	0.607													3	70					0	0	0	0	G	40951132	G	G	40951132	3	3	55	1	0	0	0	0	1	0	0	0	3650	188	7	5	49	5	CNTD1	17	40951132	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	1448650	40951132	40244078	349	11082											
RUNDC1	146923	broad.mit.edu	37	chr17	41141370	41141370	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttggtaggtgatcatagatGagttaataaagaaactggac	15	11	11	4	0	1	4	1	2	0	2	1	5	1	5	0	3	1	2	0	3	6	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:41141370G>C	uc002ici.1	+	3	682	c.670G>C	c.(670-672)GAG>CAG	p.E224Q	RUNDC1_uc010whi.1_5'UTR	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	224	Potential.										0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		GATCATAGATGAGTTAATAAA	0.433													22	56					0	0	0	0	C	41141370	C	C	41141370	3	2	55	1	0	0	0	0	1	0	0	0	13807	1291	45	2	680	2	RUNDC1	17	41141370	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	190238	41141370	40053840	350	11083											
RUNDC1	146923	broad.mit.edu	37	chr17	41141510	41141510	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaacagttggttgagcaactGaaaactcagatccgagacct	14	8	10	9	1	1	4	1	2	0	2	2	6	2	4	2	1	4	3	2	1	4	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:41141510G>C	uc002ici.1	+	3	822	c.810G>C	c.(808-810)CTG>CTC	p.L270L	RUNDC1_uc010whi.1_Silent_p.L40L	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	270											0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		TTGAGCAACTGAAAACTCAGA	0.478													35	85					0	0	0	0	C	41141510	C	C	41141510	2	2	55	1	0	0	0	0	0	0	0	1	13807	1277	45	2		2	RUNDC1	17	41141510	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	140	41141510	40053700	351	11084											
C17orf57	124989	broad.mit.edu	37	chr17	45481247	45481247	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttttttctatttatagagtTacaggaagttgtcttagctg	9	20	8	4	0	2	1	0	0	2	1	2	2	2	2	0	1	2	3	0	1	6	10			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:45481247T>A	uc002iln.2	+	19	2432	c.2021T>A	c.(2020-2022)TTA>TAA	p.L674*	C17orf57_uc002ilm.2_Nonsense_Mutation_p.L578*	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	674							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						TTTATAGAGTTACAGGAAGTT	0.343													34	115					0	0	0	0	A	45481247	A	A	45481247	4	1	55	1	0	0	0	0	0	1	0	0	1872	1764	61	5	2083	5	C17orf57	17	45481247	Nonsense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	4339737	45481247	35713963	352	11085											
MYCBPAP	84073	broad.mit.edu	37	chr17	48601147	48601147	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgagaggaaagtactggaggTaagggacccaggaccatggc	13	5	16	7	0	0	1	0	1	0	1	0	6	0	5	2	6	1	2	2	6	3	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:48601147T>A	uc010wmr.1	+	12	1926	c.1764_splice	c.e12+2	p.E588_splice	MYCBPAP_uc002iqz.2_Splice_Site	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein						cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GTACTGGAGGTAAGGGACCCA	0.532													15	49					0	0	0	0	A	48601147	A	A	48601147	5	1	55	1	0	0	0	0	0	0	1	0	10072	1652	57	5	1812	5	MYCBPAP	17	48601147	Splice_Site	SNP	T	TCGA-CN-5356-01A-01D-1434-08	3119900	48601147	32594063	353	11086											
MMD	23531	broad.mit.edu	37	chr17	53471830	53471830	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgatgccatcactcttgaaGaacacaactcccaagcaata	16	8	5	12	0	2	3	1	2	1	1	3	3	3	3	2	0	4	1	2	0	6	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:53471830G>A	uc002iui.2	-	7	867	c.582C>T	c.(580-582)TTC>TTT	p.F194F		NM_012329	NP_036461	Q15546	PAQRB_HUMAN	monocyte to macrophage	194	Helical; (Potential).				cytolysis	integral to plasma membrane|late endosome membrane|lysosomal membrane|membrane fraction	receptor activity				0						CACTCTTGAAGAACACAACTC	0.453													26	89					0	0	0	0	A	53471830	A	A	53471830	2	1	55	1	0	0	0	0	0	0	0	1	9696	933	33	2		2	MMD	17	53471830	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	4870683	53471830	27723380	354	11087											
SEPT9	10801	broad.mit.edu	37	chr17	75488797	75488797	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctggtgaacgagaagttccGggtgagtggatccactagga	10	8	16	7	2	0	3	0	2	0	1	2	6	2	5	2	4	1	2	2	4	3	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:75488797G>C	uc002jts.3	+	9	1601	c.1475G>C	c.(1474-1476)CGG>CCG	p.R492P	SEPT9_uc010wtk.1_Missense_Mutation_p.R473P|SEPT9_uc002jtt.3_Missense_Mutation_p.R328P|SEPT9_uc002jtu.3_Missense_Mutation_p.R474P|SEPT9_uc002jtv.2_Missense_Mutation_p.R485P|SEPT9_uc002jtw.2_Missense_Mutation_p.R328P|SEPT9_uc010wtl.1_Missense_Mutation_p.R268P|SEPT9_uc002jty.3_Missense_Mutation_p.R241P|SEPT9_uc010wtm.1_Missense_Mutation_p.R241P|SEPT9_uc010wtn.1_Missense_Mutation_p.R241P|SEPT9_uc010dhd.2_Missense_Mutation_p.R380P	NM_001113491	NP_001106963	Q9UHD8	SEPT9_HUMAN	septin 9 isoform a	492					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding|protein binding			breast(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(99;0.153)			GAGAAGTTCCGGGTGAGTGGA	0.557													59	170					0	0	0	0	C	75488797	C	C	75488797	3	2	55	1	0	0	0	0	1	0	0	0	14136	1130	39	3	1983	3	SEPT9	17	75488797	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	22016967	75488797	5706413	355	11088											
RPTOR	57521	broad.mit.edu	37	chr17	78820280	78820280	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgccccgcagcacagccCgttcttcgccgagcagctga	6	7	11	17	4	1	1	0	1	1	0	2	2	1	1	4	0	5	6	4	0	0	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr17:78820280C>T	uc002jyt.1	+	11	2025	c.1220C>T	c.(1219-1221)CCG>CTG	p.P407L	RPTOR_uc010wuf.1_Missense_Mutation_p.P222L|RPTOR_uc010wug.1_Missense_Mutation_p.P407L	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	407					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CAGCACAGCCCGTTCTTCGCC	0.632													5	166					0	0	0	0	T	78820280	T	T	78820280	3	4	55	1	0	0	0	0	1	0	0	0	13730	652	23	1	1262	1	RPTOR	17	78820280	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3331483	78820280	2374930	356	11089											
LAMA1	284217	broad.mit.edu	37	chr18	6980533	6980533	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttacctttaggaattgcTctaagtatcaagagtgattc	12	14	7	8	0	2	2	1	1	1	1	3	3	2	3	1	1	2	2	1	1	6	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:6980533T>A	uc002knm.2	-	42	6088	c.5994A>T	c.(5992-5994)AGA>AGT	p.R1998S	LAMA1_uc010wzj.1_Missense_Mutation_p.R1474S	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1998	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAGGAATTGCTCTAAGTATCA	0.373													25	62					0	0	0	0	A	6980533	A	A	6980533	3	1	55	1	0	0	0	0	1	0	0	0	8645	1548	54	5	3321	5	LAMA1	18	6980533	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08		6980533	71096715	357	11090											
PTPRM	5797	broad.mit.edu	37	chr18	8069752	8069752	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcaaatcactatccgctggGagccatttggatataatgta	12	11	10	8	1	1	0	1	0	0	0	2	2	2	2	2	3	1	3	2	3	5	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:8069752G>C	uc002knn.3	+	8	1704	c.1201G>C	c.(1201-1203)GAG>CAG	p.E401Q	PTPRM_uc010dkv.2_Missense_Mutation_p.E401Q|PTPRM_uc010wzl.1_Missense_Mutation_p.E188Q	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	401	Fibronectin type-III 2.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				TATCCGCTGGGAGCCATTTGG	0.418													20	56					0	0	0	0	C	8069752	C	C	8069752	3	2	55	1	0	0	0	0	1	0	0	0	12871	1175	41	2	1231	2	PTPRM	18	8069752	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	1089219	8069752	70007496	358	11091											
NPC1	4864	broad.mit.edu	37	chr18	21136302	21136302	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgtcagtgagaggggcccGgatgatgagctgctccgtcc	6	10	15	10	2	1	3	1	3	0	1	3	5	3	4	3	3	2	2	3	3	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:21136302G>A	uc002kum.3	-	8	1505	c.1231C>T	c.(1231-1233)CGG>TGG	p.R411W	NPC1_uc010xaz.1_Missense_Mutation_p.R212W|NPC1_uc010xba.1_Missense_Mutation_p.R256W	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	411					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AGAGGGGCCCGGATGATGAGC	0.552													10	52					0	0	0	0	A	21136302	A	A	21136302	3	1	55	1	0	0	0	0	1	0	0	0	10624	1115	39	1	2677	1	NPC1	18	21136302	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	13066550	21136302	56940946	359	11092											
ZNF521	25925	broad.mit.edu	37	chr18	22806498	22806498	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatcagacctgggtcctgagCttcatgcacttgcttaagat	10	12	9	10	0	2	3	2	1	0	2	3	3	3	3	2	1	3	3	2	1	2	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:22806498C>T	uc002kvk.2	-	4	1631	c.1384G>A	c.(1384-1386)GCT>ACT	p.A462T	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.A462T|ZNF521_uc002kvl.2_Missense_Mutation_p.A242T	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	462					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GGGTCCTGAGCTTCATGCACT	0.463			T	PAX5	ALL								22	53					0	0	0	0	T	22806498	T	T	22806498	3	4	55	1	0	0	0	0	1	0	0	0	18032	797	28	4	2571	4	ZNF521	18	22806498	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	1670196	22806498	55270750	360	11093											
CDH2	1000	broad.mit.edu	37	chr18	25585919	25585919	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatgtcaatggggttctcCacttgatttccattaatatc	11	15	6	9	0	2	1	1	1	1	0	5	1	3	1	2	2	0	1	2	2	4	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:25585919C>T	uc002kwg.2	-	6	1200	c.741G>A	c.(739-741)GTG>GTA	p.V247V	CDH2_uc010xbn.1_Silent_p.V216V	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	247	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TGGGGTTCTCCACTTGATTTC	0.368													64	129					0	0	0	0	T	25585919	T	T	25585919	2	4	55	1	0	0	0	0	0	0	0	1	3120	581	21	4		4	CDH2	18	25585919	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2779421	25585919	52491329	361	11094											
DCC	1630	broad.mit.edu	37	chr18	50278744	50278744	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcaaaagttgcagtagcaGgtaggtggattcttccttct	10	12	11	8	0	2	0	0	0	2	0	3	1	3	1	1	3	3	6	1	3	4	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:50278744G>T	uc002lfe.1	+	2	999	c.412G>T	c.(412-414)GGA>TGA	p.G138*	DCC_uc010xdr.1_5'UTR	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	138	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGCAGTAGCAGGTAGGTGGAT	0.308													20	50					6.33239e-15	7.43564e-15	1	0	T	50278744	T	T	50278744	4	4	55	1	0	0	0	0	0	1	0	0	4299	1014	35	4	418	4	DCC	18	50278744	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	24692825	50278744	27798504	362	11095											
CNDP1	84735	broad.mit.edu	37	chr18	72247436	72247436	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatggttgtttccatgactcTaggactacacccgtggattg	8	13	11	9	1	1	1	0	1	1	0	2	4	2	3	2	3	1	2	2	3	2	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:72247436T>C	uc002llq.2	+	10	1449	c.1238T>C	c.(1237-1239)CTA>CCA	p.L413P	CNDP1_uc002lls.2_Missense_Mutation_p.L216P	NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	413					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		TCCATGACTCTAGGACTACAC	0.423													26	43					0	0	0	0	C	72247436	C	C	72247436	3	2	55	1	0	0	0	0	1	0	0	0	3608	1522	53	5	1276	5	CNDP1	18	72247436	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	21968692	72247436	5829812	363	11096											
NFATC1	4772	broad.mit.edu	37	chr18	77246597	77246597	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacgcaccccggctcgccCgggcagccacccccggccct	4	2	11	24	5	0	0	0	0	0	0	1	0	0	0	8	3	1	3	8	3	0	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr18:77246597C>T	uc010xfg.1	+	9	2895	c.2442C>T	c.(2440-2442)CCC>CCT	p.P814P	NFATC1_uc002lnd.2_Silent_p.P814P|NFATC1_uc002lne.2_Silent_p.P342P|NFATC1_uc010xfh.1_Intron|NFATC1_uc010xfj.1_Silent_p.P342P|NFATC1_uc002lnf.2_Silent_p.P801P|NFATC1_uc002lng.2_Silent_p.P801P|NFATC1_uc010xfk.1_Intron	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	814	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CCGGCTCGCCCGGGCAGCCAC	0.751													3	16					0	0	0	0	T	77246597	T	T	77246597	2	4	55	1	0	0	0	0	0	0	0	1	10415	639	23	1		1	NFATC1	18	77246597	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	4999161	77246597	830651	364	11097											
AP3D1	8943	broad.mit.edu	37	chr19	2109208	2109208	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacttagcaaaggcgtcacTgtgggagggacagggaggct	11	6	16	8	1	1	0	1	0	0	0	1	3	1	3	0	5	2	2	0	5	3	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:2109208T>C	uc002luz.2	-	28	3388	c.3165_splice	c.e28-1	p.S1055_splice	AP3D1_uc010dsv.2_Splice_Site_p.S145_splice|AP3D1_uc002luy.2_Splice_Site_p.S1014_splice|AP3D1_uc002lva.2_Splice_Site_p.S1117_splice	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1						eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGGCGTCACTGTGGGAGGGA	0.582													72	167					0	0	0	0	C	2109208	C	C	2109208	5	2	55	1	0	0	0	0	0	0	1	0	746	1594	55	5	310	5	AP3D1	19	2109208	Splice_Site	SNP	T	TCGA-CN-5356-01A-01D-1434-08		2109208	57019775	365	11098											
DOT1L	84444	broad.mit.edu	37	chr19	2226522	2226522	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacacagcttcagtgatggTgcttctcttccccacaaggg	8	12	9	12	0	2	1	1	1	1	0	4	1	3	1	2	2	3	2	2	2	2	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:2226522T>C	uc002lvb.3	+	27	4038	c.4002T>C	c.(4000-4002)GGT>GGC	p.G1334G	DOT1L_uc002lvc.1_Silent_p.G628G	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1334						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAGTGATGGTGCTTCTCTTC	0.701													6	55					0	0	0	0	C	2226522	C	C	2226522	2	2	55	1	0	0	0	0	0	0	0	1	4731	1683	59	5		5	DOT1L	19	2226522	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	117314	2226522	56902461	366	11099											
PLIN4	729359	broad.mit.edu	37	chr19	4504669	4504669	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tagagctcacagaggctgtgCcgcgcccgccccactggctg	6	6	13	16	3	1	2	1	0	0	2	1	2	1	2	4	2	2	3	4	2	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:4504669C>T	uc002mar.1	-	6	3876	c.3876G>A	c.(3874-3876)CGG>CGA	p.R1292R	PLIN4_uc010dub.1_Silent_p.R316R	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	1292						lipid particle|plasma membrane					0						AGAGGCTGTGCCGCGCCCGCC	0.701													3	6					0	0	0	0	T	4504669	T	T	4504669	2	4	55	1	0	0	0	0	0	0	0	1	12147	726	26	4		4	PLIN4	19	4504669	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2278147	4504669	54624314	367	11100											
EMR1	2015	broad.mit.edu	37	chr19	6913820	6913820	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cctcagcaaatatcactccgGctgttcggacggaatactta	11	10	8	12	3	2	0	2	0	0	0	4	2	3	2	2	3	2	3	2	3	5	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:6913820G>T	uc002mfw.2	+	11	1317	c.1279G>T	c.(1279-1281)GCT>TCT	p.A427S	EMR1_uc010dvc.2_Missense_Mutation_p.A427S|EMR1_uc010dvb.2_Missense_Mutation_p.A375S|EMR1_uc010xji.1_Missense_Mutation_p.A286S|EMR1_uc010xjj.1_Missense_Mutation_p.A250S	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	427	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TATCACTCCGGCTGTTCGGAC	0.498													52	188					7.37877e-41	9.68095e-41	1	0	T	6913820	T	T	6913820	3	4	55	1	0	0	0	0	1	0	0	0	5128	1203	42	4	1321	4	EMR1	19	6913820	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2409151	6913820	52215163	368	11101											
KIAA1543	57662	broad.mit.edu	37	chr19	7676418	7676418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccaggctccctgaagtcttCcccgtccatgtcccatatgg	6	10	8	17	1	1	1	0	1	1	0	5	1	5	1	6	2	0	1	6	2	2	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:7676418C>T	uc002mgv.3	+	10	1240	c.1139C>T	c.(1138-1140)TCC>TTC	p.S380F	KIAA1543_uc002mgu.3_Missense_Mutation_p.S407F	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	380					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						CTGAAGTCTTCCCCGTCCATG	0.642													4	49					0	0	0	0	T	7676418	T	T	7676418	3	4	55	1	0	0	0	0	1	0	0	0	8282	855	30	2	1266	2	KIAA1543	19	7676418	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	762598	7676418	51452565	369	11102											
FBN3	84467	broad.mit.edu	37	chr19	8138159	8138159	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctcccgcaggtggggggCgacagggcacactcattctc	6	6	15	14	3	2	0	1	0	1	0	4	1	3	0	1	5	0	3	1	5	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:8138159C>A	uc002mjf.2	-	61	7746	c.7725G>T	c.(7723-7725)TCG>TCT	p.S2575S	FBN3_uc002mje.2_Silent_p.S371S	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2575	EGF-like 43; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						AGGTGGGGGGCGACAGGGCAC	0.657													5	52					0.00116845	0.00120772	1	0	A	8138159	A	A	8138159	2	1	55	1	0	0	0	0	0	0	0	1	5736	755	27	3		3	FBN3	19	8138159	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	461741	8138159	50990824	370	11103											
OR7D4	125958	broad.mit.edu	37	chr19	9324750	9324750	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aactcagatagaccccaagtCctgttccatagaacaaggag	15	7	8	11	0	1	3	1	0	0	3	3	4	3	4	4	1	2	1	4	1	6	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:9324750C>A	uc002mla.1	-	1	764	c.764G>T	c.(763-765)GGA>GTA	p.G255V		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GACCCCAAGTCCTGTTCCATA	0.537													19	85					5.35267e-07	5.83927e-07	1	0	A	9324750	A	A	9324750	3	1	55	1	0	0	0	0	1	0	0	0	11274	855	30	2	178	2	OR7D4	19	9324750	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	1186591	9324750	49804233	371	11104											
SMARCA4	6597	broad.mit.edu	37	chr19	11144078	11144078	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatcctagctgcagccaagtAcaagctcaacgtggaccaga	13	6	10	12	1	1	1	1	0	0	1	2	3	2	2	3	1	6	4	3	1	5	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:11144078A>G	uc002mqf.3	+	26	3943	c.3659A>G	c.(3658-3660)TAC>TGC	p.Y1220C	SMARCA4_uc010dxp.2_Missense_Mutation_p.Y1220C|SMARCA4_uc010dxo.2_Missense_Mutation_p.Y1220C|SMARCA4_uc010dxq.2_Missense_Mutation_p.Y1220C|SMARCA4_uc010dxr.2_Missense_Mutation_p.Y1220C|SMARCA4_uc002mqj.3_Missense_Mutation_p.Y1220C|SMARCA4_uc010dxs.2_Missense_Mutation_p.Y1220C|SMARCA4_uc010dxt.1_Missense_Mutation_p.Y440C|SMARCA4_uc002mqh.3_Missense_Mutation_p.Y343C|SMARCA4_uc002mqi.1_Missense_Mutation_p.Y423C	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1220	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCAGCCAAGTACAAGCTCAAC	0.632			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				24	130					0	0	0	0	G	11144078	G	G	11144078	3	3	55	1	0	0	0	0	1	0	0	0	14834	391	14	5	3757	5	SMARCA4	19	11144078	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	1819328	11144078	47984905	372	11105											
ZNF429	353088	broad.mit.edu	37	chr19	21720875	21720875	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggagatcgagaccgtcctGgctaacatggtgaaaccccg	11	6	12	12	3	0	3	0	1	0	2	2	5	1	3	4	3	2	1	4	3	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:21720875G>T	uc002nqd.1	+	4	2157	c.2020G>T	c.(2020-2022)GGC>TGC	p.G674C	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	674					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						agaccgtcctggctaacatgg	0.02													3	18					0.004672	0.00480884	1	0	T	21720875	T	T	21720875	3	4	55	1	0	0	0	0	1	0	0	0	17969	1348	47	4	2034	4	ZNF429	19	21720875	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	10576797	21720875	37408108	373	11106											
ZNF43	7594	broad.mit.edu	37	chr19	21992324	21992324	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attctttgcatttgaaaagtTttttttcagtatggcttatc	9	21	6	5	0	2	1	1	1	1	0	3	1	2	1	0	1	1	4	0	1	4	9			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:21992324T>G	uc002nqj.2	-	4	645	c.515A>C	c.(514-516)AAA>ACA	p.K172T	ZNF43_uc010ecv.2_Missense_Mutation_p.K166T|ZNF43_uc002nql.2_Missense_Mutation_p.K166T|ZNF43_uc002nqm.2_Missense_Mutation_p.K166T|ZNF43_uc002nqk.2_Missense_Mutation_p.K102T	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TTTGAAAAGTTTTTTTTCAGT	0.313													4	61					0	0	0	0	G	21992324	G	G	21992324	3	3	55	1	0	0	0	0	1	0	0	0	17970	1841	64	5	1918	5	ZNF43	19	21992324	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	271449	21992324	37136659	374	11107											
ZNF676	163223	broad.mit.edu	37	chr19	22363959	22363959	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctccagtatgaatactcttaTaataagtaagggttgaggac	14	12	9	6	0	1	2	0	2	1	0	2	3	2	3	1	2	1	3	1	2	7	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:22363959T>C	uc002nqs.1	-	3	878	c.560A>G	c.(559-561)TAT>TGT	p.Y187C		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	187	C2H2-type 1; degenerate.			TLTYYKSI -> NLMEHKRV (in Ref. 2; BAC05174).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AATACTCTTATAATAAGTAAG	0.338													28	158					0	0	0	0	C	22363959	C	C	22363959	3	2	55	1	0	0	0	0	1	0	0	0	18150	1406	49	5	1210	5	ZNF676	19	22363959	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	371635	22363959	36765024	375	11108											
ZNF99	7652	broad.mit.edu	37	chr19	22939865	22939865	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatttctccctagtatgaatTagcttatgtttcttaagggt	9	18	8	6	0	2	1	0	1	2	0	3	2	2	1	1	1	1	3	1	1	6	7			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:22939865T>C	uc010xrh.1	-	6	2466	c.2466A>G	c.(2464-2466)CTA>CTG	p.L822L		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TAGTATGAATTAGCTTATGTT	0.373													27	147					0	0	0	0	C	22939865	C	C	22939865	2	2	55	1	0	0	0	0	0	0	0	1	18271	1741	61	5		5	ZNF99	19	22939865	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	575906	22939865	36189118	376	11109											
ZNF536	9745	broad.mit.edu	37	chr19	31039729	31039729	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacctgggcctctccaataTgatcagctctctagactctg	9	11	8	13	0	4	3	1	1	3	2	6	3	4	3	3	1	1	1	3	1	3	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:31039729T>C	uc002nsu.1	+	4	3341	c.3203T>C	c.(3202-3204)ATG>ACG	p.M1068T	ZNF536_uc010edd.1_Missense_Mutation_p.M1068T	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1068					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CTCTCCAATATGATCAGCTCT	0.562													24	108					0	0	0	0	C	31039729	C	C	31039729	3	2	55	1	0	0	0	0	1	0	0	0	18041	1464	51	5	3213	5	ZNF536	19	31039729	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	8099864	31039729	28089254	377	11110											
GPI	2821	broad.mit.edu	37	chr19	34887334	34887334	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttaccagctcatccaccaAggtaggcccctgtggcctgg	7	10	10	14	0	1	0	1	0	0	0	2	0	2	0	6	4	2	2	6	4	3	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:34887334A>T	uc002nvg.1	+	13	1294	c.1191A>T	c.(1189-1191)CAA>CAT	p.Q397H	GPI_uc002nvf.2_Missense_Mutation_p.Q436H|GPI_uc010xrv.1_Missense_Mutation_p.Q408H|GPI_uc010xrw.1_Missense_Mutation_p.Q369H|GPI_uc010edl.1_Missense_Mutation_p.Q397H|GPI_uc002nvi.1_Missense_Mutation_p.Q60H	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	397					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					TCATCCACCAAGGTAGGCCCC	0.567													44	108					0	0	0	0	T	34887334	T	T	34887334	3	4	55	1	0	0	0	0	1	0	0	0	6649	86	3	5	1362	5	GPI	19	34887334	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	3847605	34887334	24241649	378	11111											
FFAR1	2864	broad.mit.edu	37	chr19	35842987	35842987	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaggcctgggacccggcctCtgccggcccggcccgcttca	3	5	15	18	4	2	0	1	0	1	0	2	2	2	2	6	6	1	1	6	6	0	1	rs143187042		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:35842987C>G	uc002nzc.2	+	1	543	c.533C>G	c.(532-534)TCT>TGT	p.S178C		NM_005303	NP_005294	O14842	FFAR1_HUMAN	free fatty acid receptor 1	178	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	GACCCGGCCTCTGCCGGCCCG	0.677													11	70					0	0	0	0	G	35842987	G	G	35842987	3	3	55	1	0	0	0	0	1	0	0	0	5859	913	32	2	535	2	FFAR1	19	35842987	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	955653	35842987	23285996	379	11112											
SIPA1L3	23094	broad.mit.edu	37	chr19	38572979	38572979	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggggcggcggcggagccaaGggggactcccacaacgggca	8	1	20	12	4	0	0	0	0	0	0	1	2	1	2	2	8	2	1	2	8	2	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:38572979G>T	uc002ohk.2	+	3	1283	c.774G>T	c.(772-774)AAG>AAT	p.K258N		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	258					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCGGAGCCAAGGGGGACTCCC	0.721													9	21					9.70103e-10	1.0897e-09	1	0	T	38572979	T	T	38572979	3	4	55	1	0	0	0	0	1	0	0	0	14396	991	35	4	776	4	SIPA1L3	19	38572979	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	2729992	38572979	20556004	380	11113											
ZNF526	116115	broad.mit.edu	37	chr19	42730364	42730364	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgagctcggactttgacgctAcagcctcccagatcaccatc	9	8	8	16	3	1	2	1	1	0	1	4	4	2	3	3	1	3	2	3	1	1	2	rs145952747		TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:42730364A>G	uc002osz.1	+	3	1965	c.1809A>G	c.(1807-1809)CTA>CTG	p.L603L		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	603					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				CTTTGACGCTACAGCCTCCCA	0.617													25	104					0	0	0	0	G	42730364	G	G	42730364	2	3	55	1	0	0	0	0	0	0	0	1	18034	378	14	5		5	ZNF526	19	42730364	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08	4157385	42730364	16398619	381	11114											
LILRB3	11025	broad.mit.edu	37	chr19	54723084	54723084	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggacgaaggccaccgagaccCcaatcaaaacctccaggtat	14	4	9	14	2	1	1	1	0	0	1	2	4	2	2	6	3	1	1	6	3	5	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:54723084C>G	uc002qef.1	-	8	1451	c.1340G>C	c.(1339-1341)GGG>GCG	p.G447A	LILRB3_uc002qee.1_Missense_Mutation_p.G447A|LILRB3_uc002qeh.1_Missense_Mutation_p.G447A|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Missense_Mutation_p.G447A|LILRA6_uc002qek.1_Missense_Mutation_p.G447A|LILRB3_uc010erh.1_Missense_Mutation_p.G464A|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Missense_Mutation_p.G447A|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.G447A|LILRB3_uc002qep.1_Missense_Mutation_p.G447A|LILRB3_uc002qeq.1_Missense_Mutation_p.G447A|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.G447A	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	447	Helical; (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity	p.G447R(1)		skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CACCGAGACCCCAATCAAAAC	0.343													7	12					0	0	0	0	G	54723084	G	G	54723084	3	3	55	1	0	0	0	0	1	0	0	0	8833	623	22	4	582	4	LILRB3	19	54723084	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	11992720	54723084	4405899	382	11115											
LILRA4	23547	broad.mit.edu	37	chr19	54849458	54849458	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagggtcacgttcactcctGaggtcaccacagggcttggc	7	8	14	12	1	3	1	3	1	0	0	4	2	4	2	2	5	0	2	2	5	0	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:54849458G>C	uc002qfj.2	-	4	461	c.404C>G	c.(403-405)TCA>TGA	p.S135*	LILRA4_uc002qfi.2_Nonsense_Mutation_p.S69*	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	135	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GTTCACTCCTGAGGTCACCAC	0.582													10	95					0	0	0	0	C	54849458	C	C	54849458	4	2	55	1	0	0	0	0	0	1	0	0	8828	1294	45	2	1115	2	LILRA4	19	54849458	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	126374	54849458	4279525	383	11116											
ZSCAN1	284312	broad.mit.edu	37	chr19	58565248	58565248	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaccgaggaagaaagccccCcggagcaagggcccccggga	11	0	14	16	3	0	1	0	0	0	1	0	5	0	4	7	4	2	1	7	4	3	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:58565248C>A	uc002qrc.1	+	6	1303	c.1056C>A	c.(1054-1056)CCC>CCA	p.P352P		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	352					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGAAAGCCCCCCGGAGCAAGG	0.662													11	65					1.58986e-06	1.72294e-06	1	0	A	58565248	A	A	58565248	2	1	55	1	0	0	0	0	0	0	0	1	18293	610	22	4		4	ZSCAN1	19	58565248	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3715790	58565248	563735	384	11117											
A1BG	1	broad.mit.edu	37	chr19	58864486	58864486	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggagtctccaggtgggcctGgcacgtcagcgtcacattgg	6	9	15	11	2	3	0	2	0	1	0	4	1	3	1	2	5	1	1	2	5	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr19:58864486G>A	uc002qsd.3	-	3	210	c.148C>T	c.(148-150)CAG>TAG	p.Q50*	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_Intron	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	50	Ig-like V-type 1.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		AGGTGGGCCTGGCACGTCAGC	0.592													94	96					0	0	0	0	A	58864486	A	A	58864486	4	1	55	1	0	0	0	0	0	1	0	0	1	1357	47	4	1363	4	A1BG	19	58864486	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	299238	58864486	264497	385	11118											
BPI	671	broad.mit.edu	37	chr20	36954720	36954720	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atccatgtctcagcctccacCccgccacacctgtctgtgca	7	9	6	19	1	2	0	1	0	2	0	5	0	4	0	7	0	2	1	7	0	0	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr20:36954720C>A	uc002xib.2	+	10	1121	c.1059C>A	c.(1057-1059)ACC>ACA	p.T353T		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	353					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				CAGCCTCCACCCCGCCACACC	0.557													22	33					5.45024e-15	6.4305e-15	1	0	A	36954720	A	A	36954720	2	1	55	1	0	0	0	0	0	0	0	1	1495	610	22	4		4	BPI	20	36954720	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08		36954720	26070800	386	11119											
ZNF334	55713	broad.mit.edu	37	chr20	45131697	45131697	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtttgtgtcaaatgtttaTcttggatttccttgttcttc	6	21	7	7	0	3	0	1	0	2	0	5	1	4	1	1	1	0	3	1	1	2	8			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr20:45131697T>C	uc002xsc.2	-	5	465	c.281A>G	c.(280-282)GAT>GGT	p.D94G	ZNF334_uc002xsa.2_Missense_Mutation_p.D117G|ZNF334_uc002xsb.2_Missense_Mutation_p.D56G|ZNF334_uc002xsd.2_Missense_Mutation_p.D56G|ZNF334_uc010ghl.2_Missense_Mutation_p.D93G	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				CAAATGTTTATCTTGGATTTC	0.338													42	36					0	0	0	0	C	45131697	C	C	45131697	3	2	55	1	0	0	0	0	1	0	0	0	17918	1435	50	5	1765	5	ZNF334	20	45131697	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	8176977	45131697	17893823	387	11120											
COL20A1	57642	broad.mit.edu	37	chr20	61943100	61943100	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcatccgtgccaggaccCgtgagtgctccaaccccggc	6	5	14	16	3	0	1	0	1	0	0	2	2	2	2	6	4	3	2	6	4	1	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr20:61943100C>A	uc011aau.1	+	13	1763	c.1663C>A	c.(1663-1665)CCC>ACC	p.P555T	COL20A1_uc011aav.1_Missense_Mutation_p.P376T	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	555					cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					TGCCAGGACCCGTGAGTGCTC	0.692													5	7					0.00116845	0.00120772	1	0	A	61943100	A	A	61943100	3	1	55	1	0	0	0	0	1	0	0	0	3694	666	23	3	1709	3	COL20A1	20	61943100	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	16811403	61943100	1082420	388	11121											
TPTE	7179	broad.mit.edu	37	chr21	10934071	10934071	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acattatgatcatcaatcatGattctaacgaccctattatg	14	14	4	9	1	4	2	3	2	1	0	4	3	4	2	1	0	1	0	1	0	5	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr21:10934071G>C	uc002yip.1	-	16	1274	c.906C>G	c.(904-906)ATC>ATG	p.I302M	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.I284M|TPTE_uc002yir.1_Missense_Mutation_p.I264M|TPTE_uc010gkv.1_Missense_Mutation_p.I164M	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	302	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CATCAATCATGATTCTAACGA	0.313													41	280					0	0	0	0	C	10934071	C	C	10934071	3	2	55	1	0	0	0	0	1	0	0	0	16497	1280	45	2	785	2	TPTE	21	10934071	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08		10934071	37195824	389	11122											
TPTE	7179	broad.mit.edu	37	chr21	10952935	10952935	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaatgcaaaggatgatacaaTtgaatgcacaattttcttaa	18	12	6	5	0	1	2	0	2	1	0	1	3	1	3	0	1	3	2	0	1	7	5	rs146617486	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr21:10952935T>C	uc002yip.1	-	9	630	c.262A>G	c.(262-264)ATT>GTT	p.I88V	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.I70V|TPTE_uc002yir.1_Missense_Mutation_p.I50V|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	88					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GATGATACAATTGAATGCACA	0.224													19	154					0	0	0	0	C	10952935	C	C	10952935	3	2	55	1	0	0	0	0	1	0	0	0	16497	1493	52	5	1457	5	TPTE	21	10952935	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	18864	10952935	37176960	390	11123											
BAGE2	85319	broad.mit.edu	37	chr21	11058268	11058268	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gataatgatacatctgggtaCatttctcttcacagcatttg	11	15	7	8	0	3	1	1	1	2	0	4	2	3	1	0	1	3	2	0	1	3	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr21:11058268C>T	uc002yit.1	-	3	380	c.172G>A	c.(172-174)GTA>ATA	p.V58I	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CATCTGGGTACATTTCTCTTC	0.423													7	317					0	0	0	0	T	11058268	T	T	11058268	3	4	55	1	0	0	0	0	1	0	0	0	1294	478	17	4	165	4	BAGE2	21	11058268	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	105333	11058268	37071627	391	11124											
MYO18B	84700	broad.mit.edu	37	chr22	26422890	26422890	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggaaatcgaaggggccgCtggtggtctcttgaggtcca	7	9	15	10	2	1	1	0	1	1	0	4	3	2	2	3	6	0	1	3	6	2	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:26422890C>A	uc003abz.1	+	43	7200	c.6950C>A	c.(6949-6951)GCT>GAT	p.A2317D	MYO18B_uc003aca.1_Missense_Mutation_p.A2198D|MYO18B_uc010guy.1_Missense_Mutation_p.A2199D|MYO18B_uc010guz.1_Missense_Mutation_p.A2197D|MYO18B_uc011aka.1_Missense_Mutation_p.A1471D|MYO18B_uc011akb.1_Missense_Mutation_p.A1830D|MYO18B_uc010gva.1_Missense_Mutation_p.A300D|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2317						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GAAGGGGCCGCTGGTGGTCTC	0.587													24	68					1.66031e-10	1.87786e-10	1	0	A	26422890	A	A	26422890	3	1	55	1	0	0	0	0	1	0	0	0	10119	797	28	4	7116	4	MYO18B	22	26422890	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08		26422890	24881676	392	11125											
ZNRF3	84133	broad.mit.edu	37	chr22	29446545	29446546	+	Frame_Shift_Ins	INS	-	G	G																															aggtggcccgcgggggcggaINSgggggcagcggctgctacac																										TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:29446545_29446546insG	uc003aeg.2	+	8	2241_2242	c.2076_2077insG	c.(2074-2079)GGAGGGfs	p.G692fs	ZNRF3_uc003aeh.1_Frame_Shift_Ins_p.G692fs	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	792_793	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						GCGGGGGCGGAGGGGGCAGCGG	0.658													---	---	---								G	29446546	G	G	29446545	7	5	55	1	0	1	1	0	0	0	0	0	18280	291	11	0	2102	0	ZNRF3	22	29446545	Frame_Shift_Ins	INS	-	TCGA-CN-5356-01A-01D-1434-08	3023655	29446545	21858021	393	11126											
SLC5A4	6527	broad.mit.edu	37	chr22	32625260	32625260	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggtgaagagggtgctggCgctgttgaagatggaggtca	10	9	18	4	1	1	4	1	2	0	2	1	5	1	5	0	5	1	3	0	5	3	1	rs144357030	byFrequency	TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:32625260C>T	uc003ami.2	-	11	1203	c.1201G>A	c.(1201-1203)GCC>ACC	p.A401T		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	401	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						AGGGTGCTGGCGCTGTTGAAG	0.577													58	145					0	0	0	0	T	32625260	T	T	32625260	3	4	55	1	0	0	0	0	1	0	0	0	14731	768	27	1	798	1	SLC5A4	22	32625260	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	3178715	32625260	18679306	394	11127											
CYTH4	27128	broad.mit.edu	37	chr22	37708147	37708147	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacggcagggtggtggagggCaagcacgaatcgtaccgcat	10	5	17	9	4	0	0	0	0	0	0	1	3	0	1	1	5	2	5	1	5	3	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:37708147C>A	uc003arf.2	+	12	1160	c.1044C>A	c.(1042-1044)GGC>GGA	p.G348G	CYTH4_uc011amw.1_Silent_p.G291G|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	348	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TGGTGGAGGGCAAGCACGAAT	0.627													13	65					0.000151284	0.000159383	1	0	A	37708147	A	A	37708147	2	1	55	1	0	0	0	0	0	0	0	1	4223	697	25	4		4	CYTH4	22	37708147	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	5082887	37708147	13596419	395	11128											
APOBEC3D	140564	broad.mit.edu	37	chr22	39421332	39421332	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcataaggcaggggcccgTgtgaagatcatggactatga	11	8	14	8	1	1	3	1	2	0	1	1	4	1	4	1	4	1	2	1	4	3	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:39421332T>C	uc011aoe.1	+	3	522	c.468T>C	c.(466-468)CGT>CGC	p.R156R	APOBEC3D_uc011aod.1_Silent_p.R156R|APOBEC3D_uc011aof.1_Intron|APOBEC3D_uc003awu.3_Intron|APOBEC3D_uc003awt.3_Silent_p.R156R|APOBEC3D_uc010gxu.2_Intron	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	156					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					CAGGGGCCCGTGTGAAGATCA	0.592													39	48					0	0	0	0	C	39421332	C	C	39421332	2	2	55	1	0	0	0	0	0	0	0	1	792	1683	59	5		5	APOBEC3D	22	39421332	Silent	SNP	T	TCGA-CN-5356-01A-01D-1434-08	1713185	39421332	11883234	396	11129											
MGAT3	4248	broad.mit.edu	37	chr22	39883967	39883967	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgcccagggaggtgccGcgccgcgtcatcaacgccat	6	6	14	15	5	2	0	2	0	0	0	2	1	2	1	4	3	3	0	4	3	1	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:39883967G>A	uc003axv.3	+	2	854	c.615G>A	c.(613-615)CCG>CCA	p.P205P	MGAT3_uc010gxy.2_Silent_p.P205P	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	205	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					GGGAGGTGCCGCGCCGCGTCA	0.677													6	16					0	0	0	0	A	39883967	A	A	39883967	2	1	55	1	0	0	0	0	0	0	0	1	9597	1074	38	1		1	MGAT3	22	39883967	Silent	SNP	G	TCGA-CN-5356-01A-01D-1434-08	462635	39883967	11420599	397	11130											
TUBGCP6	85378	broad.mit.edu	37	chr22	50656953	50656953	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaagcagacgtccttgagcgCccacatcatgagcttcagct	10	8	10	13	2	2	3	2	2	0	1	3	4	3	3	2	0	4	3	2	0	1	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chr22:50656953C>T	uc003bkb.1	-	22	5430	c.4918G>A	c.(4918-4920)GCG>ACG	p.A1640T	TUBGCP6_uc003bka.1_Missense_Mutation_p.A727T|TUBGCP6_uc010har.1_Missense_Mutation_p.A1632T|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1640					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCCTTGAGCGCCCACATCATG	0.652													14	75					0	0	0	0	T	50656953	T	T	50656953	3	4	55	1	0	0	0	0	1	0	0	0	16838	739	26	4	557	4	TUBGCP6	22	50656953	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	10772986	50656953	647613	398	11131											
CDKL5	6792	broad.mit.edu	37	chrX	18602398	18602398	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaggttttgctcgtaatcTgtcagaaggcaataatgcta	11	14	9	7	1	3	1	2	0	1	1	4	1	3	1	0	2	2	5	0	2	5	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:18602398T>G	uc004cym.2	+	8	732	c.479T>G	c.(478-480)CTG>CGG	p.L160R	CDKL5_uc004cyn.2_Missense_Mutation_p.L160R	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	160	Protein kinase.				neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					GCTCGTAATCTGTCAGAAGGC	0.383													30	116					0	0	0	0	G	18602398	G	G	18602398	3	3	55	1	0	0	0	0	1	0	0	0	3172	1580	55	5	505	5	CDKL5	23	18602398	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08		18602398	136668162	399	11132											
DCAF8L1	139425	broad.mit.edu	37	chrX	27998655	27998655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cattaattagttctgctaccCgtacctgtccatcatggcca	9	13	6	13	1	2	0	1	0	1	0	3	0	3	0	4	1	3	3	4	1	4	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:27998655C>T	uc004dbx.1	-	1	912	c.797G>A	c.(796-798)CGG>CAG	p.R266Q		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	266	WD 2.									ovary(3)|skin(1)	4						TTCTGCTACCCGTACCTGTCC	0.493													27	40					0	0	0	0	T	27998655	T	T	27998655	3	4	55	1	0	0	0	0	1	0	0	0	4294	652	23	1	1009	1	DCAF8L1	23	27998655	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	9396257	27998655	127271905	400	11133											
MAGEB4	4115	broad.mit.edu	37	chrX	30260456	30260456	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcagagagagccacccacCacctctgctgctgcagctat	9	7	8	17	0	2	2	1	0	1	2	2	3	2	2	5	0	5	4	5	0	1	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:30260456C>G	uc004dcb.2	+	1	288	c.204C>G	c.(202-204)ACC>ACG	p.T68T	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	68										ovary(1)	1						AGCCACCCACCACCTCTGCTG	0.532													15	13					0	0	0	0	G	30260456	G	G	30260456	2	3	55	1	0	0	0	0	0	0	0	1	9231	581	21	4		4	MAGEB4	23	30260456	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	2261801	30260456	125010104	401	11134											
CACNA1F	778	broad.mit.edu	37	chrX	49075889	49075889	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agacatgatggtggatgaggGtgtggcagcccttcctcagc	8	9	15	9	0	1	3	1	2	0	1	2	4	2	4	2	4	2	1	2	4	0	1			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:49075889G>T	uc004dnb.2	-	21	2659	c.2597C>A	c.(2596-2598)ACC>AAC	p.T866N	CACNA1F_uc010nip.2_Missense_Mutation_p.T855N	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	866	III.|Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GTGGATGAGGGTGTGGCAGCC	0.567													5	7					0.00198382	0.0020462	1	0	T	49075889	T	T	49075889	3	4	55	1	0	0	0	0	1	0	0	0	2555	1261	44	4	3448	4	CACNA1F	23	49075889	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	18815433	49075889	106194671	402	11135											
GSPT2	23708	broad.mit.edu	37	chrX	51488052	51488052	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataagtacaaagatatgggcActgtggtcctgggaaagctg	13	9	13	6	0	0	1	0	0	0	1	1	2	1	2	1	3	2	3	1	3	5	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:51488052A>C	uc004dpl.2	+	1	1556	c.1330A>C	c.(1330-1332)ACT>CCT	p.T444P		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	444					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					AGATATGGGCACTGTGGTCCT	0.413													33	30					0	0	0	0	C	51488052	C	C	51488052	3	2	55	1	0	0	0	0	1	0	0	0	6866	159	6	5	1332	5	GSPT2	23	51488052	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	2412163	51488052	103782508	403	11136											
FOXO4	4303	broad.mit.edu	37	chrX	70321491	70321491	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagaatgcctcaggatctaGatcttgatatgtatatggag	13	12	10	6	0	3	3	1	1	2	2	3	5	3	5	1	2	1	1	1	2	5	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:70321491G>C	uc004dys.1	+	2	1764	c.1411G>C	c.(1411-1413)GAT>CAT	p.D471H	FOXO4_uc010nkz.2_Intron|FOXO4_uc004dyt.1_Missense_Mutation_p.D416H	NM_005938	NP_005929	P98177	FOXO4_HUMAN	forkhead box O4	471					cell cycle arrest|cell differentiation|embryo development|G1 phase of mitotic cell cycle|insulin receptor signaling pathway|mitotic cell cycle G2/M transition DNA damage checkpoint|muscle organ development|negative regulation of angiogenesis|negative regulation of cell proliferation|negative regulation of smooth muscle cell differentiation|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(2)|prostate(1)	3	Renal(35;0.156)					TCAGGATCTAGATCTTGATAT	0.527													46	42					0	0	0	0	C	70321491	C	C	70321491	3	2	55	1	0	0	0	0	1	0	0	0	6059	942	33	2	1417	2	FOXO4	23	70321491	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	18833439	70321491	84949069	404	11137											
TBX22	50945	broad.mit.edu	37	chrX	79282239	79282239	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcataagtacaaaccccgaGtgcacgtgatagagcaaggc	14	6	11	10	2	0	2	0	1	0	1	0	3	0	2	2	1	5	4	2	1	5	3			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:79282239G>T	uc010nmg.1	+	6	804	c.670G>T	c.(670-672)GTG>TTG	p.V224L	TBX22_uc004edi.1_Missense_Mutation_p.V104L|TBX22_uc004edj.1_Missense_Mutation_p.V224L	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	224	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CAAACCCCGAGTGCACGTGAT	0.453													37	44					1.30998e-17	1.58747e-17	1	0	T	79282239	T	T	79282239	3	4	55	1	0	0	0	0	1	0	0	0	15724	1029	36	4	688	4	TBX22	23	79282239	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	8960748	79282239	75988321	405	11138											
NXF3	56000	broad.mit.edu	37	chrX	102332615	102332615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactagggtgaacaaggcaCtctgggtcccttggtggctg	7	9	15	10	0	1	1	0	1	1	0	2	1	2	1	1	5	1	3	1	5	3	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:102332615C>T	uc004eju.2	-	18	1582	c.1511G>A	c.(1510-1512)AGT>AAT	p.S504N	NXF3_uc010noi.1_3'UTR	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	504						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						GAACAAGGCACTCTGGGTCCC	0.567													63	32					0	0	0	0	T	102332615	T	T	102332615	3	4	55	1	0	0	0	0	1	0	0	0	10839	565	20	4	92	4	NXF3	23	102332615	Missense_Mutation	SNP	C	TCGA-CN-5356-01A-01D-1434-08	23050376	102332615	52937945	406	11139											
PAK3	5063	broad.mit.edu	37	chrX	110385414	110385414	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggggtttgatgcagtcaccgGggaattcactgtaagtaagc	10	10	14	7	1	2	1	2	1	0	0	2	2	2	2	1	4	2	4	1	4	3	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:110385414G>C	uc004epa.2	+	2	293	c.266G>C	c.(265-267)GGG>GCG	p.G89A	PAK3_uc010npt.1_Missense_Mutation_p.G89A|PAK3_uc010npu.1_Missense_Mutation_p.G89A|PAK3_uc004eoy.1_5'UTR|PAK3_uc004eoz.2_Missense_Mutation_p.G89A|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.G89A|PAK3_uc010npw.1_Missense_Mutation_p.G89A	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	89	Autoregulatory region (By similarity).|Linker.|GTPase-binding (By similarity).				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						GCAGTCACCGGGGAATTCACT	0.418										TSP Lung(19;0.15)			82	80					0	0	0	0	C	110385414	C	C	110385414	3	2	55	1	0	0	0	0	1	0	0	0	11456	1232	43	4	272	4	PAK3	23	110385414	Missense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	8052799	110385414	44885146	407	11140											
BCORL1	63035	broad.mit.edu	37	chrX	129171509	129171509	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agtgcgcaggacggcacgagGcaagagggctgcatctcccc	9	4	15	13	3	1	1	0	0	1	1	2	3	1	2	2	4	2	5	2	4	1	0			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:129171509G>A	uc004evb.1	+	9	4586	c.4472_splice	c.e9+1	p.R1491_splice	BCORL1_uc004evc.1_Splice_Site_p.R327_splice	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						ACGGCACGAGGCAAGAGGGCT	0.582													49	46					0	0	0	0	A	129171509	A	A	129171509	5	1	55	1	0	0	0	0	0	0	1	0	1389	1217	42	4	4729	4	BCORL1	23	129171509	Splice_Site	SNP	G	TCGA-CN-5356-01A-01D-1434-08	18786095	129171509	26099051	408	11141											
MAGEC1	9947	broad.mit.edu	37	chrX	140994507	140994507	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agtgcttttgagggttttccCcagtctcctctccagattcc	5	15	8	13	0	2	2	0	1	2	1	6	2	4	2	5	1	1	2	5	1	0	5			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:140994507C>T	uc004fbt.2	+	4	1603	c.1317C>T	c.(1315-1317)CCC>CCT	p.P439P	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	439							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGTTTTCCCCAGTCTCCTC	0.453										HNSCC(15;0.026)			108	106					0	0	0	0	T	140994507	T	T	140994507	2	4	55	1	0	0	0	0	0	0	0	1	9233	610	22	4		4	MAGEC1	23	140994507	Silent	SNP	C	TCGA-CN-5356-01A-01D-1434-08	11822998	140994507	14276053	409	11142											
SLITRK4	139065	broad.mit.edu	37	chrX	142717807	142717807	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgcatttaaaggtttcggtAtcagttcagacatagactgt	11	14	9	7	2	2	2	2	0	0	2	4	2	2	2	0	2	0	4	0	2	4	6			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:142717807A>G	uc004fbx.2	-	2	1494	c.1118T>C	c.(1117-1119)ATA>ACA	p.I373T	SLITRK4_uc004fby.2_Missense_Mutation_p.I373T	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	373	Extracellular (Potential).|LRRNT.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTTTCGGTATCAGTTCAGA	0.443													103	76					0	0	0	0	G	142717807	G	G	142717807	3	3	55	1	0	0	0	0	1	0	0	0	14809	449	16	5	1399	5	SLITRK4	23	142717807	Missense_Mutation	SNP	A	TCGA-CN-5356-01A-01D-1434-08	1723300	142717807	12552753	410	11143											
AFF2	2334	broad.mit.edu	37	chrX	148037158	148037158	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaccctcaaccaacaagtGgcaactggataaatggctta	14	7	8	12	0	1	0	1	0	0	0	1	1	1	1	3	3	3	2	3	3	7	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:148037158G>A	uc004fcp.2	+	11	2062	c.1583G>A	c.(1582-1584)TGG>TAG	p.W528*	AFF2_uc004fcq.2_Nonsense_Mutation_p.W518*|AFF2_uc004fcr.2_Nonsense_Mutation_p.W489*|AFF2_uc011mxb.1_Nonsense_Mutation_p.W493*|AFF2_uc004fcs.2_Nonsense_Mutation_p.W495*|AFF2_uc011mxc.1_Nonsense_Mutation_p.W169*	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	528					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ACCAACAAGTGGCAACTGGAT	0.443													115	107					0	0	0	0	A	148037158	A	A	148037158	4	1	55	1	0	0	0	0	0	1	0	0	357	1357	47	4	1680	4	AFF2	23	148037158	Nonsense_Mutation	SNP	G	TCGA-CN-5356-01A-01D-1434-08	5319351	148037158	7233402	411	11144											
MAGEA12	4111	broad.mit.edu	37	chrX	151900745	151900745	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagcccagggcctctcctTgggcctcaaggccttcctca	6	8	9	18	0	3	0	2	0	1	0	5	0	4	0	7	3	1	0	7	3	2	2			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrX:151900745T>C	uc010ntp.2	-	3	410	c.56A>G	c.(55-57)CAA>CGA	p.Q19R	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.Q19R|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	19										skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCTCTCCTTGGGCCTCAAG	0.617													19	50					0	0	0	0	C	151900745	C	C	151900745	3	2	55	1	0	0	0	0	1	0	0	0	9217	1812	63	5	892	5	MAGEA12	23	151900745	Missense_Mutation	SNP	T	TCGA-CN-5356-01A-01D-1434-08	3863587	151900745	3369815	412	11145											
NLGN4Y	22829	broad.mit.edu	37	chrY	16953106	16953106	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggaggacaaaacagtacAaatttaccccacggacattc	16	7	8	10	1	0	0	0	0	0	0	1	3	0	3	2	3	3	1	2	3	5	4			TCGA-CN-5356-01A-01D-1434-08	TCGA-CN-5356-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	aad13fa4-b2e7-4c89-9936-57cf7a5e16a4	5f41279c-51ec-45fc-9046-a5111226eab5	g.chrY:16953106A>T	uc004ftg.2	+	6	2667	c.2415A>T	c.(2413-2415)ACA>ACT	p.T805T	NLGN4Y_uc004fte.2_Silent_p.T637T|NLGN4Y_uc011nas.1_Silent_p.T825T|NLGN4Y_uc004ftf.2_Silent_p.T498T|NLGN4Y_uc004fth.2_Silent_p.T805T	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	805	Cytoplasmic (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						AAAACAGTACAAATTTACCCC	0.433													23	17					0	0	0	0	T	16953106	T	T	16953106	2	4	55	1	0	0	0	0	0	0	0	1	10519	117	5	5		5	NLGN4Y	24	16953106	Silent	SNP	A	TCGA-CN-5356-01A-01D-1434-08		16953106	42420460	413	11146											
HTR1D	3352	broad.mit.edu	37	chr1	23520602	23520602	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accacggcaagggagatcttGagcgcctggagggtcctggg	8	6	17	10	2	1	2	0	1	1	1	2	4	2	3	3	5	1	1	3	5	1	1			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr1:23520602G>C	uc001bgn.2	-	1	621	c.111C>G	c.(109-111)CTC>CTG	p.L37L		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	37	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	GGGAGATCTTGAGCGCCTGGA	0.567													9	126					0	0	0	0	C	23520602	C	C	23520602	2	2	56	1	0	0	0	0	0	0	0	1	7477	1277	45	2		2	HTR1D	1	23520602	Silent	SNP	G	TCGA-CN-5358-01A-01D-1512-08		23520602	225730019	1	11147											
GPATCH3	63906	broad.mit.edu	37	chr1	27226896	27226896	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taccgctcactaccaggtaaActgtcgcctcctcctccgcc	7	9	6	19	3	1	0	1	0	0	0	5	0	4	0	7	1	3	2	7	1	4	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr1:27226896A>G	uc001bne.2	-	1	67	c.38T>C	c.(37-39)GTT>GCT	p.V13A	GPATCH3_uc009vsp.1_5'UTR	NM_022078	NP_071361	Q96I76	GPTC3_HUMAN	G patch domain containing 3	13						intracellular	nucleic acid binding				0		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		TACCAGGTAAACTGTCGCCTC	0.592													3	68					0	0	0	0	G	27226896	G	G	27226896	3	3	56	1	0	0	0	0	1	0	0	0	6630	43	2	5	1567	5	GPATCH3	1	27226896	Missense_Mutation	SNP	A	TCGA-CN-5358-01A-01D-1512-08	3706294	27226896	222023725	2	11148											
JAK1	3716	broad.mit.edu	37	chr1	65307005	65307005	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcagttgctggttttttttCtgaaacaatatctggatcta	9	19	7	6	0	4	1	1	1	3	0	4	2	4	2	0	2	2	3	0	2	4	8	rs67572613		TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr1:65307005C>G	uc001dbu.1	-	19	2821	c.2572G>C	c.(2572-2574)GAA>CAA	p.E858Q	JAK1_uc009wam.1_Missense_Mutation_p.E846Q|JAK1_uc009wal.1_Missense_Mutation_p.E35Q	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	858					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		GGTTTTTTTTCTGAAACAATA	0.473			Mis		ALL								16	143					0	0	0	0	G	65307005	G	G	65307005	3	3	56	1	0	0	0	0	1	0	0	0	7976	922	32	2	920	2	JAK1	1	65307005	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	38080109	65307005	183943616	3	11149											
FCRLB	127943	broad.mit.edu	37	chr1	161697058	161697058	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttctcccctggacccggcctCcaccaccgccccagctccat	5	7	6	23	2	1	0	0	0	1	0	4	1	3	1	10	2	1	1	10	2	0	1			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr1:161697058C>G	uc001gbh.2	+	8	1121	c.887C>G	c.(886-888)TCC>TGC	p.S296C	FCRLB_uc009wus.2_Missense_Mutation_p.S296C|FCRLB_uc001gbj.2_Missense_Mutation_p.P248A|FCRLB_uc001gbk.2_Silent_p.L261L|FCRLB_uc001gbl.2_Missense_Mutation_p.P241A|FCRLB_uc001gbm.2_Silent_p.L254L|FCRLB_uc001gbi.2_Missense_Mutation_p.S296C|FCRLB_uc001gbn.3_Silent_p.L298L	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	296						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			GACCCGGCCTCCACCACCGCC	0.582													3	47					0	0	0	0	G	161697058	G	G	161697058	3	3	56	1	0	0	0	0	1	0	0	0	5833	855	30	2	909	2	FCRLB	1	161697058	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	96390053	161697058	87553563	4	11150											
GLUL	2752	broad.mit.edu	37	chr1	182355001	182355001	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgccataggctctgtctgctCccacaccacagtaatatgga	10	10	8	13	0	2	0	0	0	2	0	3	1	3	1	3	2	2	3	3	2	3	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr1:182355001C>T	uc001gpa.1	-	5	709	c.497G>A	c.(496-498)GGA>GAA	p.G166E	GLUL_uc010pnt.1_5'Flank|GLUL_uc001gpb.1_Missense_Mutation_p.G166E|GLUL_uc001gpc.1_Missense_Mutation_p.G166E|GLUL_uc001gpd.1_Missense_Mutation_p.G166E	NM_001033056	NP_001028228	P15104	GLNA_HUMAN	glutamine synthetase	166					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding				0					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	TCTGTCTGCTCCCACACCACA	0.512													14	176					0	0	0	0	T	182355001	T	T	182355001	3	4	56	1	0	0	0	0	1	0	0	0	6515	855	30	2	636	2	GLUL	1	182355001	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	20657943	182355001	66895620	5	11151											
SULT6B1	391365	broad.mit.edu	37	chr2	37410658	37410658	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatggaaagcctttcattctCttaaaaatatacacaaaaag	18	11	5	7	0	2	0	1	0	1	0	3	2	2	1	1	1	2	0	1	1	8	5			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr2:37410658C>G	uc002rpu.2	-	3	220	c.199_splice	c.e3-1	p.R67_splice	SULT6B1_uc010yni.1_Splice_Site	NM_001032377	NP_001027549	Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member							cytoplasm	sulfotransferase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(82;0.248)				CTTTCATTCTCTTAAAAATAT	0.328													3	105					0	0	0	0	G	37410658	G	G	37410658	5	3	56	1	0	0	0	0	0	0	1	0	15450	927	32	2	619	2	SULT6B1	2	37410658	Splice_Site	SNP	C	TCGA-CN-5358-01A-01D-1512-08		37410658	205788715	6	11152											
IMMT	10989	broad.mit.edu	37	chr2	86374882	86374882	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaggacatctcgcaagtgAtcagtgtgggcagctgcctg	9	9	13	10	1	2	1	1	1	1	0	3	2	2	2	1	2	2	3	1	2	2	1			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr2:86374882A>G	uc002sqz.3	-	13	1864	c.1476T>C	c.(1474-1476)GAT>GAC	p.D492D	IMMT_uc002sqy.3_Silent_p.D233D|IMMT_uc002srb.3_Silent_p.D481D|IMMT_uc002sra.3_Silent_p.D491D|IMMT_uc010ytd.1_Silent_p.D480D|IMMT_uc010yte.1_Silent_p.D445D|IMMT_uc002src.1_Silent_p.D228D	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	492	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						CTCGCAAGTGATCAGTGTGGG	0.478													8	128					0	0	0	0	G	86374882	G	G	86374882	2	3	56	1	0	0	0	0	0	0	0	1	7757	330	12	5		5	IMMT	2	86374882	Silent	SNP	A	TCGA-CN-5358-01A-01D-1512-08	48964224	86374882	156824491	7	11153											
TTN	7273	broad.mit.edu	37	chr2	179436108	179436108	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtccctggaggacagtgtGacaactggagtgccaggagg	9	7	16	9	0	0	1	0	1	0	0	1	5	1	5	2	5	2	0	2	5	1	0			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr2:179436108G>C	uc010zfg.1	-	275	67271	c.67047C>G	c.(67045-67047)GTC>GTG	p.V22349V	uc002umo.2_Intron|uc002ump.1_RNA|TTN_uc010zfh.1_Silent_p.V16044V|TTN_uc010zfi.1_Silent_p.V15977V|TTN_uc010zfj.1_Silent_p.V15852V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23276							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGACAGTGTGACAACTGGAG	0.468													6	157					0	0	0	0	C	179436108	C	C	179436108	2	2	56	1	0	0	0	0	0	0	0	1	16803	1277	45	2		2	TTN	2	179436108	Silent	SNP	G	TCGA-CN-5358-01A-01D-1512-08	93061226	179436108	63763265	8	11154											
VIL1	7429	broad.mit.edu	37	chr2	219313973	219313973	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtccattgaagatttcactCaggcctttgggatgactcca	9	13	9	10	0	2	3	2	2	0	1	4	4	4	4	3	2	0	0	3	2	1	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr2:219313973C>G	uc002via.2	+	20	2463	c.2398C>G	c.(2398-2400)CAG>GAG	p.Q800E	VIL1_uc010zke.1_Missense_Mutation_p.Q489E|VIL1_uc002vib.2_Missense_Mutation_p.Q800E	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	800	Headpiece.|HP.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGATTTCACTCAGGCCTTTGG	0.493													6	353					0	0	0	0	G	219313973	G	G	219313973	3	3	56	1	0	0	0	0	1	0	0	0	17232	827	29	2	2472	2	VIL1	2	219313973	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	39877865	219313973	23885400	9	11155											
UGT1A8	54576	broad.mit.edu	37	chr2	234527158	234527158	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaaacccgtgatgcccaatAtgatcttcattggtggtatc	10	12	8	11	1	2	2	1	2	1	0	3	2	2	2	3	2	2	1	3	2	4	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr2:234527158A>G	uc002vup.2	+	1	868	c.805A>G	c.(805-807)ATG>GTG	p.M269V	UGT1A8_uc010zmv.1_Missense_Mutation_p.M269V	NM_019076	NP_061949	Q9HAW9	UD18_HUMAN	UDP glycosyltransferase 1 family, polypeptide A8	269					drug metabolic process|fatty acid metabolic process|flavone metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme inhibitor activity|fatty acid binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|steroid binding			ovary(2)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		GATGCCCAATATGATCTTCAT	0.433													33	408					0	0	0	0	G	234527158	G	G	234527158	3	3	56	1	0	0	0	0	1	0	0	0	17019	449	16	5	807	5	UGT1A8	2	234527158	Missense_Mutation	SNP	A	TCGA-CN-5358-01A-01D-1512-08	15213185	234527158	8672215	10	11156											
DHX30	22907	broad.mit.edu	37	chr3	47882464	47882464	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgccgacagctggtggcGtccggaacccaccatgcccc	6	5	11	19	3	0	0	0	0	0	0	1	2	1	1	7	3	4	1	7	3	1	0	rs139889547		TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr3:47882464G>A	uc003cru.2	+	7	890	c.464G>A	c.(463-465)CGT>CAT	p.R155H	DHX30_uc003crs.2_Missense_Mutation_p.R116H|DHX30_uc003crt.2_Missense_Mutation_p.R116H|DHX30_uc010hjr.1_Missense_Mutation_p.R183H	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	155						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		AGCTGGTGGCGTCCGGAACCC	0.617													7	53					0	0	0	0	A	47882464	A	A	47882464	3	1	56	1	0	0	0	0	1	0	0	0	4526	1145	40	1	493	1	DHX30	3	47882464	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08		47882464	150139966	11	11157											
NISCH	11188	broad.mit.edu	37	chr3	52505975	52505975	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacatcctggacttcacctgTcgccttaagtaccttaaggt	9	12	7	13	1	1	0	1	0	0	0	3	1	2	1	4	2	1	1	4	2	3	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr3:52505975T>G	uc011beg.1	+	6	627	c.555T>G	c.(553-555)TGT>TGG	p.C185W	NISCH_uc003ded.3_Missense_Mutation_p.C185W|NISCH_uc003dec.1_Missense_Mutation_p.C185W	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	185	Necessary for homooligomerization and targeting to endosomes.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		ACTTCACCTGTCGCCTTAAGT	0.617											OREG0015615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	64					0	0	0	0	G	52505975	G	G	52505975	3	3	56	1	0	0	0	0	1	0	0	0	10486	1673	58	5	573	5	NISCH	3	52505975	Missense_Mutation	SNP	T	TCGA-CN-5358-01A-01D-1512-08	4623511	52505975	145516455	12	11158											
FXR1	8087	broad.mit.edu	37	chr3	180666565	180666565	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcagtaggagcatgcagaaTtttttaccatccagaaacaa	16	9	8	8	0	0	2	0	0	0	2	1	3	1	3	2	1	5	4	2	1	5	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr3:180666565T>A	uc003fkq.2	+	6	498	c.476T>A	c.(475-477)ATT>AAT	p.I159N	FXR1_uc003fkp.2_Missense_Mutation_p.I74N|FXR1_uc003fkr.2_Missense_Mutation_p.I159N|FXR1_uc011bqj.1_Missense_Mutation_p.I73N|FXR1_uc003fks.2_Missense_Mutation_p.I73N|FXR1_uc011bqk.1_Missense_Mutation_p.I110N|FXR1_uc011bql.1_Missense_Mutation_p.I146N	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	159					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GCATGCAGAATTTTTTACCAT	0.303													6	169					0	0	0	0	A	180666565	A	A	180666565	3	1	56	1	0	0	0	0	1	0	0	0	6149	1493	52	5	498	5	FXR1	3	180666565	Missense_Mutation	SNP	T	TCGA-CN-5358-01A-01D-1512-08	128160590	180666565	17355865	13	11159											
CPLX1	10815	broad.mit.edu	37	chr4	786392	786392	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcttccccatgtccttggtGgcccctggtacagaagttgg	6	12	11	12	0	1	1	0	0	1	1	3	1	3	1	5	4	1	2	5	4	2	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:786392G>A	uc003gbi.2	-	3	227	c.36C>T	c.(34-36)GCC>GCT	p.A12A	CPLX1_uc003gbj.2_Silent_p.A12A	NM_006651	NP_006642	O14810	CPLX1_HUMAN	complexin 1	12					glutamate secretion	cytosol					0				Colorectal(103;0.187)		TGTCCTTGGTGGCCCCTGGTA	0.662													11	93					0	0	0	0	A	786392	A	A	786392	2	1	56	1	0	0	0	0	0	0	0	1	3819	1335	47	4		4	CPLX1	4	786392	Silent	SNP	G	TCGA-CN-5358-01A-01D-1512-08		786392	190367884	14	11160											
TBC1D1	23216	broad.mit.edu	37	chr4	38138875	38138875	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggtcggccctgctgcagacGgtggaggagctgcggcggcg	4	5	20	12	6	0	1	0	0	0	1	1	3	0	3	1	7	4	3	1	7	0	0			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:38138875G>A	uc003gtb.2	+	20	3769	c.3426G>A	c.(3424-3426)ACG>ACA	p.T1142T	TBC1D1_uc011byd.1_Silent_p.T1133T|TBC1D1_uc010ifd.2_Silent_p.T929T|TBC1D1_uc003gtd.2_Silent_p.T154T	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	1142						nucleus	Rab GTPase activator activity			ovary(1)	1						TGCTGCAGACGGTGGAGGAGC	0.642													7	60					0	0	0	0	A	38138875	A	A	38138875	2	1	56	1	0	0	0	0	0	0	0	1	15663	1103	39	1		1	TBC1D1	4	38138875	Silent	SNP	G	TCGA-CN-5358-01A-01D-1512-08	37352483	38138875	153015401	15	11161											
SHROOM3	57619	broad.mit.edu	37	chr4	77692006	77692006	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggcgtctagcccgtgttgaGaatgtccttagcggccttgg	5	11	15	10	3	1	1	0	1	1	1	2	2	2	1	3	3	2	1	3	3	3	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:77692006G>C	uc011cbx.1	+	10	6530	c.5577G>C	c.(5575-5577)GAG>GAC	p.E1859D	SHROOM3_uc003hkg.2_Missense_Mutation_p.E1637D	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1859	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CCCGTGTTGAGAATGTCCTTA	0.502													6	157					0	0	0	0	C	77692006	C	C	77692006	3	2	56	1	0	0	0	0	1	0	0	0	14360	933	33	2	5615	2	SHROOM3	4	77692006	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	39553131	77692006	113462270	16	11162											
EGF	1950	broad.mit.edu	37	chr4	110834553	110834553	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttagttttgttagtctctCagcaccgcagcactggagct	8	14	9	10	1	2	0	1	0	1	0	3	1	2	1	1	1	3	6	1	1	2	5			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:110834553C>T	uc003hzy.3	+	1	514	c.62C>T	c.(61-63)TCA>TTA	p.S21L	EGF_uc011cfu.1_Missense_Mutation_p.S21L|EGF_uc011cfv.1_Missense_Mutation_p.S21L	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	21					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GTTAGTCTCTCAGCACCGCAG	0.428													4	75					0	0	0	0	T	110834553	T	T	110834553	3	4	56	1	0	0	0	0	1	0	0	0	4984	838	29	2	64	2	EGF	4	110834553	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	33142547	110834553	80319723	17	11163											
ANK2	287	broad.mit.edu	37	chr4	114279449	114279449	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agtgtagggaccaaggacctCcccaccgtgcaaacgggtga	11	5	13	12	2	0	1	0	1	0	0	1	3	1	3	5	3	2	2	5	3	3	1			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:114279449C>T	uc003ibe.3	+	38	9775	c.9675C>T	c.(9673-9675)CTC>CTT	p.L3225L	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Silent_p.L527L|ANK2_uc011cgb.1_Silent_p.L3240L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3192					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCAAGGACCTCCCCACCGTGC	0.478													10	106					0	0	0	0	T	114279449	T	T	114279449	2	4	56	1	0	0	0	0	0	0	0	1	621	842	30	2		2	ANK2	4	114279449	Silent	SNP	C	TCGA-CN-5358-01A-01D-1512-08	3444896	114279449	76874827	18	11164											
ANK2	287	broad.mit.edu	37	chr4	114279897	114279897	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccagaagacagtggctcctCagggacaggacatggcaagc	12	5	13	11	0	1	2	1	0	0	2	3	4	3	4	2	4	1	2	2	4	2	0			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:114279897C>G	uc003ibe.3	+	38	10223	c.10123C>G	c.(10123-10125)CAG>GAG	p.Q3375E	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.Q677E|ANK2_uc011cgb.1_Missense_Mutation_p.Q3390E	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3342					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGTGGCTCCTCAGGGACAGGA	0.468													9	103					0	0	0	0	G	114279897	G	G	114279897	3	3	56	1	0	0	0	0	1	0	0	0	621	827	29	2	10338	2	ANK2	4	114279897	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	448	114279897	76874379	19	11165											
RICTOR	253260	broad.mit.edu	37	chr5	38944564	38944564	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacgttaaaagcccagtctCatgacatttagttgaaactg	13	12	7	9	1	2	2	2	2	1	0	3	2	2	2	1	0	2	2	1	0	4	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr5:38944564C>A	uc003jlp.2	-	36	4921	c.4897G>T	c.(4897-4899)GAG>TAG	p.E1633*	RICTOR_uc003jlo.2_Nonsense_Mutation_p.E1657*|RICTOR_uc010ivf.2_Nonsense_Mutation_p.E1310*	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1633					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					AGCCCAGTCTCATGACATTTA	0.323													9	214					2.17888e-05	2.73086e-05	1	0	A	38944564	A	A	38944564	4	1	56	1	0	0	0	0	0	1	0	0	13423	835	29	2	241	2	RICTOR	5	38944564	Nonsense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08		38944564	141970696	20	11166											
SPZ1	84654	broad.mit.edu	37	chr5	79616171	79616171	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggatcacattccccttcctCctggggctctctccctttcc	3	14	6	18	0	2	0	1	0	1	0	8	1	7	1	6	3	0	1	6	3	0	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr5:79616171C>T	uc003kgn.2	+	1	382	c.137C>T	c.(136-138)TCC>TTC	p.S46F	uc011ctk.1_RNA	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		TCCCCTTCCTCCTGGGGCTCT	0.403													7	225					0	0	0	0	T	79616171	T	T	79616171	3	4	56	1	0	0	0	0	1	0	0	0	15193	855	30	2	139	2	SPZ1	5	79616171	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	40671607	79616171	101299089	21	11167											
PITX1	5307	broad.mit.edu	37	chr5	134364577	134364577	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcaggctggctaggctcgaGttgcacgtgtcccggtagac	6	8	15	12	4	0	1	0	0	0	1	2	2	1	1	1	4	1	7	1	4	2	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr5:134364577G>C	uc010jea.2	-	3	1230	c.837C>G	c.(835-837)AAC>AAG	p.N279K	PITX1_uc011cxy.1_Missense_Mutation_p.N279K	NM_002653	NP_002644	P78337	PITX1_HUMAN	paired-like homeodomain transcription factor 1	279	Interacts with PIT-1 (By similarity).					nucleolus	sequence-specific DNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)		CTAGGCTCGAGTTGCACGTGT	0.677													3	27					0	0	0	0	C	134364577	C	C	134364577	3	2	56	1	0	0	0	0	1	0	0	0	12009	1020	36	4	111	4	PITX1	5	134364577	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	54748406	134364577	46550683	22	11168											
PCDHGB2	56103	broad.mit.edu	37	chr5	140740003	140740003	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatatgcgggaagcagcctCtgtgtgttctggatttcgat	8	13	13	7	2	2	1	0	0	2	1	3	4	2	3	1	2	3	2	1	2	2	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr5:140740003C>G	uc003ljs.1	+	1	301	c.301C>G	c.(301-303)CTG>GTG	p.L101V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Missense_Mutation_p.L101V	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	101	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGCAGCCTCTGTGTGTTCT	0.418													9	140					0	0	0	0	G	140740003	G	G	140740003	3	3	56	1	0	0	0	0	1	0	0	0	11617	912	32	2	303	2	PCDHGB2	5	140740003	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	6375426	140740003	40175257	23	11169											
PCDHGA9	56107	broad.mit.edu	37	chr5	140784546	140784546	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agacatcctggctgacctggGcagtcttcagatccctgcag	8	9	11	13	0	2	3	1	1	1	2	4	3	4	3	3	2	1	3	3	2	0	1			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr5:140784546G>A	uc003lkh.1	+	1	2027	c.2027G>A	c.(2026-2028)GGC>GAC	p.G676D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.G676D	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	676	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGACCTGGGCAGTCTTCAG	0.592													9	136					0	0	0	0	A	140784546	A	A	140784546	3	1	56	1	0	0	0	0	1	0	0	0	11615	1203	42	4	2029	4	PCDHGA9	5	140784546	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	44543	140784546	40130714	24	11170											
KIFC1	3833	broad.mit.edu	37	chr6	33372879	33372879	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcctcctcctgtttccctCtggccctggtgggccctctg	0	13	11	17	0	2	0	0	0	2	0	5	0	5	0	6	4	0	1	6	4	0	1			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr6:33372879C>T	uc003oef.3	+	7	1457	c.1007C>T	c.(1006-1008)TCT>TTT	p.S336F	KIFC1_uc011drf.1_Missense_Mutation_p.S328F	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	336	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						CTGTTTCCCTCTGGCCCTGGT	0.682													5	187					0	0	0	0	T	33372879	T	T	33372879	3	4	56	1	0	0	0	0	1	0	0	0	8351	913	32	2	1033	2	KIFC1	6	33372879	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08		33372879	137742188	25	11171											
PHF3	23469	broad.mit.edu	37	chr6	64421505	64421505	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaactgcatagacctaatCtattgttgggcttaattatt	11	17	7	6	0	1	2	0	1	1	1	1	2	1	2	1	1	2	3	1	1	6	9			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr6:64421505C>G	uc003pep.1	+	15	4047	c.4021C>G	c.(4021-4023)CTA>GTA	p.L1341V	PHF3_uc003pen.2_Missense_Mutation_p.L1253V|PHF3_uc011dxs.1_Missense_Mutation_p.L610V	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1341					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TAGACCTAATCTATTGTTGGG	0.373													13	197					0	0	0	0	G	64421505	G	G	64421505	3	3	56	1	0	0	0	0	1	0	0	0	11891	912	32	2	4079	2	PHF3	6	64421505	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	31048626	64421505	106693562	26	11172											
SASH1	23328	broad.mit.edu	37	chr6	148855896	148855896	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccctctcacaggagcacatgCccactttcctgttcaatgga	9	10	7	15	0	2	0	2	0	1	0	4	2	3	2	3	2	2	2	3	2	1	2			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr6:148855896C>T	uc003qme.1	+	16	2429	c.1954C>T	c.(1954-1956)CCC>TCC	p.P652S	SASH1_uc011eeb.1_Missense_Mutation_p.P413S|SASH1_uc003qmf.1_Missense_Mutation_p.P62S	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	652	SAM 1.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GGAGCACATGCCCACTTTCCT	0.502													4	132					0	0	0	0	T	148855896	T	T	148855896	3	4	56	1	0	0	0	0	1	0	0	0	13913	739	26	4	2016	4	SASH1	6	148855896	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	84434391	148855896	22259171	27	11173											
RAET1G	353091	broad.mit.edu	37	chr6	150240360	150240360	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attctgttttctgagtcaaaGaggaggaagatctgtccatc	11	13	10	7	0	4	3	1	1	3	2	6	5	5	5	1	2	0	1	1	2	2	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr6:150240360G>C	uc010kii.1	-	3	518	c.450C>G	c.(448-450)CTC>CTG	p.L150L	uc003qni.1_RNA|RAET1G_uc003qnm.2_RNA	NM_001001788	NP_001001788	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G precursor	150	Extracellular (Potential).|MHC class I alpha-2 like.				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		CTGAGTCAAAGAGGAGGAAGA	0.493													18	183					0	0	0	0	C	150240360	C	C	150240360	2	2	56	1	0	0	0	0	0	0	0	1	13065	929	33	2		2	RAET1G	6	150240360	Silent	SNP	G	TCGA-CN-5358-01A-01D-1512-08	1384464	150240360	20874707	28	11174											
ESR1	2099	broad.mit.edu	37	chr6	152163869	152163869	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctatgcttcaggctaccattAtggagtctggtcctgtgagg	7	13	12	9	0	2	1	1	1	1	0	3	2	3	2	2	4	2	2	2	4	3	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr6:152163869A>G	uc003qom.3	+	4	960	c.590A>G	c.(589-591)TAT>TGT	p.Y197C	ESR1_uc010kin.2_Missense_Mutation_p.Y197C|ESR1_uc010kio.2_Missense_Mutation_p.Y197C|ESR1_uc010kip.2_Missense_Mutation_p.Y197C|ESR1_uc003qon.3_Missense_Mutation_p.Y197C|ESR1_uc003qoo.3_Missense_Mutation_p.Y197C|ESR1_uc010kiq.2_Intron|ESR1_uc010kir.2_Intron|ESR1_uc011eet.1_RNA|ESR1_uc011eeu.1_RNA|ESR1_uc011eev.1_Missense_Mutation_p.Y24C|ESR1_uc011eew.1_Missense_Mutation_p.M29V	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	197	NR C4-type.|Nuclear receptor.|Mediates interaction with DNTTIP2.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	GGCTACCATTATGGAGTCTGG	0.453													8	99					0	0	0	0	G	152163869	G	G	152163869	3	3	56	1	0	0	0	0	1	0	0	0	5280	449	16	5	596	5	ESR1	6	152163869	Missense_Mutation	SNP	A	TCGA-CN-5358-01A-01D-1512-08	1923509	152163869	18951198	29	11175											
TYW1B	441250	broad.mit.edu	37	chr7	72040531	72040531	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctttctctgatgtcttgtGtccttgggatcaaagcttct	5	19	8	9	0	5	1	1	1	4	0	7	2	6	2	1	1	1	1	1	1	1	5			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr7:72040531G>T	uc011kej.1	-	17	2118	c.1959C>A	c.(1957-1959)GAC>GAA	p.D653E	TYW1B_uc011keh.1_Intron|TYW1B_uc011kei.1_Missense_Mutation_p.D279E	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	653					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GATGTCTTGTGTCCTTGGGAT	0.408													5	101					0.00116845	0.0013903	1	0	T	72040531	T	T	72040531	3	4	56	1	0	0	0	0	1	0	0	0	16887	1368	48	4	172	4	TYW1B	7	72040531	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08		72040531	87098132	30	11176											
MAGI2	9863	broad.mit.edu	37	chr7	77885568	77885568	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggacgggcggtggatacgtgCcgtctagctgaccatcagtt	7	9	15	10	4	2	1	1	1	1	0	2	3	2	3	2	4	3	2	2	4	2	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr7:77885568C>A	uc003ugx.2	-	10	1993	c.1739G>T	c.(1738-1740)GGC>GTC	p.G580V	MAGI2_uc003ugy.2_Missense_Mutation_p.G580V|MAGI2_uc010ldx.1_Missense_Mutation_p.G189V|MAGI2_uc010ldy.1_Missense_Mutation_p.G189V|MAGI2_uc011kgr.1_Missense_Mutation_p.G412V|MAGI2_uc011kgs.1_Missense_Mutation_p.G417V	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	580						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGGATACGTGCCGTCTAGCTG	0.507													4	60					0.000602214	0.000725746	1	0	A	77885568	A	A	77885568	3	1	56	1	0	0	0	0	1	0	0	0	9244	739	26	4	2680	4	MAGI2	7	77885568	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	5845037	77885568	81253095	31	11177											
ZNF804B	219578	broad.mit.edu	37	chr7	88964688	88964688	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttaaaaatgaaaaatactcaAaacgtagatattgtcactgc	19	11	5	6	1	2	2	2	1	0	1	2	2	2	2	0	0	3	1	0	0	10	5			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr7:88964688A>T	uc011khi.1	+	4	2930	c.2392A>T	c.(2392-2394)AAA>TAA	p.K798*		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	798						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AAAATACTCAAAACGTAGATA	0.348										HNSCC(36;0.09)			9	72					0	0	0	0	T	88964688	T	T	88964688	4	4	56	1	0	0	0	0	0	1	0	0	18238	15	1	5	2406	5	ZNF804B	7	88964688	Nonsense_Mutation	SNP	A	TCGA-CN-5358-01A-01D-1512-08	11079120	88964688	70173975	32	11178											
SAMD9L	219285	broad.mit.edu	37	chr7	92761232	92761232	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccatggtggtagcatctttGtagtttggattaagatattc	9	17	10	5	0	1	1	0	0	1	1	3	2	2	2	1	3	1	4	1	3	4	7			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr7:92761232G>T	uc003umh.1	-	5	5269	c.4053C>A	c.(4051-4053)TAC>TAA	p.Y1351*	SAMD9L_uc003umj.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc003umi.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc010lfb.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc003umk.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc010lfc.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc010lfd.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc011khx.1_3'UTR	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1351										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TAGCATCTTTGTAGTTTGGAT	0.388													40	232					5.59293e-11	7.20185e-11	1	0	T	92761232	T	T	92761232	4	4	56	1	0	0	0	0	0	1	0	0	13892	1372	48	4	705	4	SAMD9L	7	92761232	Nonsense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	3796544	92761232	66377431	33	11179											
CTTNBP2	83992	broad.mit.edu	37	chr7	117432666	117432666	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctcttccagtttggccattAcgtcttcgagcttctgggcc	4	14	9	14	2	3	0	0	0	3	0	5	1	4	0	4	2	2	2	4	2	1	5			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr7:117432666A>G	uc003vjf.2	-	4	676	c.584T>C	c.(583-585)GTA>GCA	p.V195A		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	195	Potential.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TTTGGCCATTACGTCTTCGAG	0.483													3	159					0	0	0	0	G	117432666	G	G	117432666	3	3	56	1	0	0	0	0	1	0	0	0	4062	391	14	5	4487	5	CTTNBP2	7	117432666	Missense_Mutation	SNP	A	TCGA-CN-5358-01A-01D-1512-08	24671434	117432666	41705997	34	11180											
GNE	10020	broad.mit.edu	37	chr9	36227321	36227321	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttagagtttcaagaataTggtcaatatcttgagagata	15	13	8	5	0	3	4	2	1	1	3	3	5	3	4	0	1	0	1	0	1	7	6			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr9:36227321T>C	uc010mlh.2	-	7	1420	c.1205A>G	c.(1204-1206)CAT>CGT	p.H402R	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Missense_Mutation_p.H402R|GNE_uc011lpl.1_Missense_Mutation_p.H292R|GNE_uc010mli.2_Missense_Mutation_p.H433R|GNE_uc010mlj.2_Missense_Mutation_p.H397R	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	402	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			TTCAAGAATATGGTCAATATC	0.408													7	102					0	0	0	0	C	36227321	C	C	36227321	3	2	56	1	0	0	0	0	1	0	0	0	6559	1464	51	5	987	5	GNE	9	36227321	Missense_Mutation	SNP	T	TCGA-CN-5358-01A-01D-1512-08		36227321	104986110	35	11181											
PAPSS2	9060	broad.mit.edu	37	chr10	89472868	89472868	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaaaacaacgataagttttgCcctggaggagtaccttgtct	13	11	9	8	1	1	0	0	0	1	0	1	3	1	2	2	2	4	2	2	2	5	5			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr10:89472868C>T	uc001kex.2	+	3	445	c.182C>T	c.(181-183)GCC>GTC	p.A61V	PAPSS2_uc001kew.2_Missense_Mutation_p.A61V|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	61	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		ATAAGTTTTGCCCTGGAGGAG	0.473													5	281					0	0	0	0	T	89472868	T	T	89472868	3	4	56	1	0	0	0	0	1	0	0	0	11489	739	26	4	192	4	PAPSS2	10	89472868	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08		89472868	46061879	36	11182											
TNKS2	80351	broad.mit.edu	37	chr10	93602119	93602119	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aaattgccgcgatacccaagGcagacattcaacacctttac	14	8	6	13	2	1	1	1	0	0	1	1	2	1	1	3	1	4	1	3	1	5	5			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr10:93602119G>A	uc001khp.2	+	16	2327	c.2030G>A	c.(2029-2031)GGC>GAC	p.G677D		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	677					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				GATACCCAAGGCAGACATTCA	0.403													5	104					0	0	0	0	A	93602119	A	A	93602119	3	1	56	1	0	0	0	0	1	0	0	0	16387	1203	42	4	2092	4	TNKS2	10	93602119	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	4129251	93602119	41932628	37	11183											
PDCD11	22984	broad.mit.edu	37	chr10	105176373	105176373	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtctgcagacacatggcttCatcatcagggtcaaggacta	11	9	11	10	0	5	1	4	0	1	1	5	2	5	2	0	4	1	2	0	4	2	2			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr10:105176373C>T	uc001kwy.1	+	13	1731	c.1644C>T	c.(1642-1644)TTC>TTT	p.F548F		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	548	S1 motif 6.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CACATGGCTTCATCATCAGGG	0.488											OREG0020494	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	131					0	0	0	0	T	105176373	T	T	105176373	2	4	56	1	0	0	0	0	0	0	0	1	11671	825	29	2		2	PDCD11	10	105176373	Silent	SNP	C	TCGA-CN-5358-01A-01D-1512-08	11574254	105176373	30358374	38	11184											
PPP2R2D	55844	broad.mit.edu	37	chr10	133769208	133769208	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgccatcatgaccgggtcctAtaacaacttcttcaggatgt	10	11	8	12	2	3	1	2	1	1	0	4	2	4	2	3	2	2	0	3	2	3	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr10:133769208A>G	uc001lks.2	+	7	1247	c.1004A>G	c.(1003-1005)TAT>TGT	p.Y335C	PPP2R2D_uc001lkr.2_Missense_Mutation_p.Y141C|PPP2R2D_uc001lkt.2_Missense_Mutation_p.Y141C|PPP2R2D_uc009yay.2_Missense_Mutation_p.Y203C	NM_018461	NP_060931	Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B,	368	WD 6.				cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			skin(1)	1		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		ACCGGGTCCTATAACAACTTC	0.602													5	39					0	0	0	0	G	133769208	G	G	133769208	3	3	56	1	0	0	0	0	1	0	0	0	12447	449	16	5	1031	5	PPP2R2D	10	133769208	Missense_Mutation	SNP	A	TCGA-CN-5358-01A-01D-1512-08	28592835	133769208	1765539	39	11185											
C11orf54	28970	broad.mit.edu	37	chr11	93488478	93488478	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagggtgcctactggagaaaTacagtgagaaatgtcatgat	14	9	13	5	0	1	3	1	2	0	2	1	6	1	3	1	2	3	0	1	2	4	2			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr11:93488478T>G	uc009ywi.2	+	7	764	c.433T>G	c.(433-435)TAC>GAC	p.Y145D	C11orf54_uc001pee.1_Intron|C11orf54_uc001pef.2_Missense_Mutation_p.Y145D|C11orf54_uc001peg.2_Missense_Mutation_p.Y145D|C11orf54_uc001peh.2_Missense_Mutation_p.Y145D|C11orf54_uc001pei.2_Missense_Mutation_p.Y126D|C11orf54_uc001pej.2_Missense_Mutation_p.Y126D|C11orf54_uc001pek.2_Missense_Mutation_p.Y34D	NM_014039	NP_054758	Q9H0W9	CK054_HUMAN	hypothetical protein LOC28970	145						nucleus	hydrolase activity, acting on ester bonds|protein binding|zinc ion binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ACTGGAGAAATACAGTGAGAA	0.423													4	105					0	0	0	0	G	93488478	G	G	93488478	3	3	56	1	0	0	0	0	1	0	0	0	1655	1406	49	5	451	5	C11orf54	11	93488478	Missense_Mutation	SNP	T	TCGA-CN-5358-01A-01D-1512-08		93488478	41518038	40	11186											
MLL	4297	broad.mit.edu	37	chr11	118390377	118390377	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggattctccatgatgcagttGtgttcctcattgagcagctg	7	14	11	9	0	2	2	1	2	1	0	4	3	3	3	2	1	3	5	2	1	0	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr11:118390377G>T	uc001pta.2	+	32	11205	c.11182G>T	c.(11182-11184)GTG>TTG	p.V3728L	MLL_uc001ptb.2_Missense_Mutation_p.V3731L	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3728	FYR C-terminal.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TGATGCAGTTGTGTTCCTCAT	0.502			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								16	151					0.000566183	0.000691185	1	0	T	118390377	T	T	118390377	3	4	56	1	0	0	0	0	1	0	0	0	9673	1377	48	4	11308	4	MLL	11	118390377	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	24901899	118390377	16616139	41	11187											
OR8D4	338662	broad.mit.edu	37	chr11	123777472	123777472	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtttgtgttatttctgaaTgctacatgctggcagccatg	7	16	11	7	0	1	1	0	1	1	0	1	1	1	1	1	1	4	5	1	1	3	4	rs139359205		TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr11:123777472T>A	uc010saa.1	+	1	334	c.334T>A	c.(334-336)TGC>AGC	p.C112S		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TATTTCTGAATGCTACATGCT	0.478													11	249					0	0	0	0	A	123777472	A	A	123777472	3	1	56	1	0	0	0	0	1	0	0	0	11287	1464	51	5	336	5	OR8D4	11	123777472	Missense_Mutation	SNP	T	TCGA-CN-5358-01A-01D-1512-08	5387095	123777472	11229044	42	11188											
ESYT1	23344	broad.mit.edu	37	chr12	56527377	56527377	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcaatttcttctagtggttCcctctacaaggtgggcaagg	8	13	10	10	0	4	0	1	0	3	0	5	0	5	0	1	4	1	2	1	4	5	5			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr12:56527377C>T	uc001sjq.2	+	12	1349	c.1299C>T	c.(1297-1299)TTC>TTT	p.F433F	ESYT1_uc001sjr.2_Silent_p.F433F	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	433						integral to membrane				ovary(4)|skin(1)	5						TCTAGTGGTTCCCTCTACAAG	0.458													6	100					0	0	0	0	T	56527377	T	T	56527377	2	4	56	1	0	0	0	0	0	0	0	1	5288	854	30	2		2	ESYT1	12	56527377	Silent	SNP	C	TCGA-CN-5358-01A-01D-1512-08		56527377	77324518	43	11189											
PITPNM2	57605	broad.mit.edu	37	chr12	123498545	123498545	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacggccggttctccaggatCtccacgccgctgccttcgcc	4	9	10	18	5	2	0	0	0	2	0	5	1	2	1	6	3	2	2	6	3	1	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr12:123498545C>G	uc001uej.1	-	3	262	c.123G>C	c.(121-123)GAG>GAC	p.E41D	PITPNM2_uc001uek.1_Missense_Mutation_p.E41D|PITPNM2_uc009zxu.1_Missense_Mutation_p.E41D	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	41					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TCTCCAGGATCTCCACGCCGC	0.587													4	108					0	0	0	0	G	123498545	G	G	123498545	3	3	56	1	0	0	0	0	1	0	0	0	12006	912	32	2	4018	2	PITPNM2	12	123498545	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	66971168	123498545	10353350	44	11190											
HMGB1	3146	broad.mit.edu	37	chr13	31037677	31037677	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccctcttaccttccacctCtctgagcacttcttagaaaa	10	12	4	15	0	3	2	0	1	3	1	5	2	4	2	4	0	3	1	4	0	4	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr13:31037677C>G	uc001usw.2	-	2	325	c.141G>C	c.(139-141)GAG>GAC	p.E47D	HMGB1_uc001usz.2_Missense_Mutation_p.E47D|HMGB1_uc001usv.2_Missense_Mutation_p.E47D|HMGB1_uc001usx.2_Missense_Mutation_p.E47D|HMGB1_uc001usy.2_Intron|HMGB1_uc001uta.1_Missense_Mutation_p.E47D	NM_002128	NP_002119	P09429	HMGB1_HUMAN	high-mobility group box 1	47	HMG box 1.				base-excision repair, DNA ligation|dendritic cell chemotaxis|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|inflammatory response to antigenic stimulus|innate immune response|myeloid dendritic cell activation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|neuron projection development|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	cell surface|condensed chromosome|extracellular space|nucleolus|nucleoplasm	chemoattractant activity|cytokine activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(1)	1		Lung SC(185;0.0257)		all cancers(112;0.072)|OV - Ovarian serous cystadenocarcinoma(117;0.177)|Lung(94;0.216)|GBM - Glioblastoma multiforme(144;0.232)		CCTTCCACCTCTCTGAGCACT	0.408													5	243					0	0	0	0	G	31037677	G	G	31037677	3	3	56	1	0	0	0	0	1	0	0	0	7264	912	32	2	522	2	HMGB1	13	31037677	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08		31037677	84132201	45	11191											
HMGB1	3146	broad.mit.edu	37	chr13	31037728	31037728	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgactgaagcatctgggtgCttcttcttatgctcctcccg	5	15	9	12	1	3	2	0	2	3	0	5	2	5	2	2	1	3	3	2	1	2	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr13:31037728C>T	uc001usw.2	-	2	274	c.90G>A	c.(88-90)AAG>AAA	p.K30K	HMGB1_uc001usz.2_Silent_p.K30K|HMGB1_uc001usv.2_Silent_p.K30K|HMGB1_uc001usx.2_Silent_p.K30K|HMGB1_uc001usy.2_Missense_Mutation_p.S15N|HMGB1_uc001uta.1_Silent_p.K30K	NM_002128	NP_002119	P09429	HMGB1_HUMAN	high-mobility group box 1	30	HMG box 1.				base-excision repair, DNA ligation|dendritic cell chemotaxis|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|inflammatory response to antigenic stimulus|innate immune response|myeloid dendritic cell activation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|neuron projection development|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	cell surface|condensed chromosome|extracellular space|nucleolus|nucleoplasm	chemoattractant activity|cytokine activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(1)	1		Lung SC(185;0.0257)		all cancers(112;0.072)|OV - Ovarian serous cystadenocarcinoma(117;0.177)|Lung(94;0.216)|GBM - Glioblastoma multiforme(144;0.232)		CATCTGGGTGCTTCTTCTTAT	0.408													6	196					0	0	0	0	T	31037728	T	T	31037728	2	4	56	1	0	0	0	0	0	0	0	1	7264	796	28	4		4	HMGB1	13	31037728	Silent	SNP	C	TCGA-CN-5358-01A-01D-1512-08	51	31037728	84132150	46	11192											
RNASE11	122651	broad.mit.edu	37	chr14	21052160	21052160	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgtttgcctgtagtgaactgGcacactgtattttccagttc	7	16	9	9	0	0	1	0	1	0	0	2	1	1	1	2	1	2	5	2	1	3	6			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr14:21052160G>T	uc010ahv.2	-	2	659	c.474C>A	c.(472-474)TGC>TGA	p.C158*	RNASE11_uc010ahx.2_Nonsense_Mutation_p.C158*|RNASE11_uc010ahw.2_Nonsense_Mutation_p.C158*|RNASE11_uc001vxs.2_Nonsense_Mutation_p.C158*	NM_145250	NP_660293	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	158						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(3)	3	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		TAGTGAACTGGCACACTGTAT	0.488													9	85					0.00448238	0.0052668	1	0	T	21052160	T	T	21052160	4	4	56	1	0	0	0	0	0	1	0	0	13466	1195	42	4	129	4	RNASE11	14	21052160	Nonsense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08		21052160	86297380	47	11193											
PLCB2	5330	broad.mit.edu	37	chr15	40591135	40591135	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaatttggtcaggtgctcCttcgtcatgtagggtttggc	6	15	13	7	1	2	1	2	1	0	0	4	1	3	1	1	4	1	3	1	4	2	4			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr15:40591135C>T	uc001zld.2	-	9	1015	c.714G>A	c.(712-714)AAG>AAA	p.K238K	PLCB2_uc010bbo.2_Silent_p.K238K|PLCB2_uc010ucm.1_Silent_p.K238K	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	238					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		TCAGGTGCTCCTTCGTCATGT	0.577													9	164					0	0	0	0	T	40591135	T	T	40591135	2	4	56	1	0	0	0	0	0	0	0	1	12083	680	24	4		4	PLCB2	15	40591135	Silent	SNP	C	TCGA-CN-5358-01A-01D-1512-08		40591135	61940257	48	11194											
DNAH3	55567	broad.mit.edu	37	chr16	21136514	21136514	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actttgtgtatcatgaaaagGgaaacgaggtcctcaagtga	14	10	11	6	1	2	2	2	2	0	0	3	4	3	3	1	2	1	1	1	2	5	2			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr16:21136514G>A	uc010vbe.1	-	9	1386	c.1386C>T	c.(1384-1386)TCC>TCT	p.S462S	DNAH3_uc002die.2_Silent_p.S433S	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	462	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCATGAAAAGGGAAACGAGGT	0.453													8	113					0	0	0	0	A	21136514	A	A	21136514	2	1	56	1	0	0	0	0	0	0	0	1	4625	1219	43	4		4	DNAH3	16	21136514	Silent	SNP	G	TCGA-CN-5358-01A-01D-1512-08		21136514	69218239	49	11195											
FTSJD1	55783	broad.mit.edu	37	chr16	71319121	71319121	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggcaatcaaaactcccatCtgcagtgaccaagtgaacag	14	8	8	11	0	2	2	1	2	1	0	3	2	3	2	2	1	3	2	2	1	5	1			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr16:71319121C>A	uc010cga.2	-	3	1109	c.703G>T	c.(703-705)GAT>TAT	p.D235Y	FTSJD1_uc002ezy.3_Missense_Mutation_p.D235Y|FTSJD1_uc002ezz.3_Missense_Mutation_p.D235Y	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	235		S-adenosyl-L-methionine (By similarity).				integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						AAACTCCCATCTGCAGTGACC	0.428													19	75					9.7654e-05	0.000120783	1	0	A	71319121	A	A	71319121	3	1	56	1	0	0	0	0	1	0	0	0	6124	913	32	2	1613	2	FTSJD1	16	71319121	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	50182607	71319121	19035632	50	11196											
TP53	7157	broad.mit.edu	37	chr17	7578222	7578223	+	Frame_Shift_Del	DEL	TC	-	-																															acactatgtcgaaaagtgttTctgtcatccaaatactccac																										TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr17:7578222_7578223delTC	uc002gim.2	-	6	820_821	c.626_627delGA	c.(625-627)AGAfs	p.R209fs	TP53_uc002gig.1_Frame_Shift_Del_p.R209fs|TP53_uc002gih.2_Frame_Shift_Del_p.R209fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.R77fs|TP53_uc010cng.1_Frame_Shift_Del_p.R77fs|TP53_uc002gii.1_Frame_Shift_Del_p.R77fs|TP53_uc010cnh.1_Frame_Shift_Del_p.R209fs|TP53_uc010cni.1_Frame_Shift_Del_p.R209fs|TP53_uc002gij.2_Frame_Shift_Del_p.R209fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.R116fs|TP53_uc002gio.2_Frame_Shift_Del_p.R77fs|TP53_uc010vug.1_Frame_Shift_Del_p.R170fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	209	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> I (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R209fs*6(31)|p.R209*(9)|p.0?(7)|p.R209T(3)|p.R209K(3)|p.R209fs*35(2)|p.D207fs*6(2)|p.R209fs*38(2)|p.K164_P219del(1)|p.E204_N210delEYLDDRN(1)|p.R209fs*36(1)|p.D207_R213delDDRNTFR(1)|p.D208_V216delDRNTFRHSV(1)|p.D208fs*1(1)|p.N210fs*7(1)|p.R209R(1)|p.R209S(1)|p.R209I(1)|p.R209_R213delRNTFR(1)|p.D207_V216del10(1)|p.R209fs*7(1)|p.R209fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAAAGTGTTTCTGTCATCCAA	0.535		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578223	-	-	7578222	7	5	56	1	0	1	0	1	0	0	0	0	16448	1780	62	0	667	0	TP53	17	7578222	Frame_Shift_Del	DEL	TC	TCGA-CN-5358-01A-01D-1512-08		7578222	73616988	51	11197											
SLFN12L	342615	broad.mit.edu	37	chr17	33806816	33806816	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acaaactggagctcaacgtgGcaatctgcggaccagaggtt	12	7	12	10	2	2	1	1	0	1	1	2	3	2	3	1	4	4	3	1	4	3	1			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr17:33806816G>A	uc002hjn.2	-	3	1379	c.500C>T	c.(499-501)GCC>GTC	p.A167V		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						GCTCAACGTGGCAATCTGCGG	0.433													3	35					0	0	0	0	A	33806816	A	A	33806816	3	1	56	1	0	0	0	0	1	0	0	0	14799	1203	42	4	1365	4	SLFN12L	17	33806816	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	26228594	33806816	47388394	52	11198											
OR4D2	124538	broad.mit.edu	37	chr17	56247483	56247483	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgggaggctttgtccactCtattgtccagctggctctga	5	13	13	10	0	2	1	0	1	2	0	4	2	4	2	2	4	1	3	2	4	1	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr17:56247483C>A	uc010wnp.1	+	1	467	c.467C>A	c.(466-468)TCT>TAT	p.S156Y		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TTTGTCCACTCTATTGTCCAG	0.567													12	120					3.07112e-06	3.90115e-06	1	0	A	56247483	A	A	56247483	3	1	56	1	0	0	0	0	1	0	0	0	11110	913	32	2	469	2	OR4D2	17	56247483	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	22440667	56247483	24947727	53	11199											
ZNF676	163223	broad.mit.edu	37	chr19	22363822	22363822	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gattgaggatcgattaaaagCtttgccacattcttcacatt	12	14	7	8	1	2	1	1	1	1	0	3	4	2	2	1	1	2	1	1	1	2	6			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:22363822C>T	uc002nqs.1	-	3	1015	c.697G>A	c.(697-699)GCT>ACT	p.A233T		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	233	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CGATTAAAAGCTTTGCCACAT	0.363													11	179					0	0	0	0	T	22363822	T	T	22363822	3	4	56	1	0	0	0	0	1	0	0	0	18150	797	28	4	1073	4	ZNF676	19	22363822	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08		22363822	36765161	54	11200											
DPY19L3	147991	broad.mit.edu	37	chr19	32923652	32923652	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaaatctcattcagaacaGagtgtggcctgtattactcc	12	11	9	9	0	2	3	2	0	1	3	4	4	3	3	2	1	2	1	2	1	4	3			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:32923652G>C	uc002ntg.2	+	4	444	c.268G>C	c.(268-270)GAG>CAG	p.E90Q	DPY19L3_uc002nth.1_Missense_Mutation_p.E90Q	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	90						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					ATTCAGAACAGAGTGTGGCCT	0.408													6	86					0	0	0	0	C	32923652	C	C	32923652	3	2	56	1	0	0	0	0	1	0	0	0	4764	943	33	2	278	2	DPY19L3	19	32923652	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	10559830	32923652	26205331	55	11201											
ZFP30	22835	broad.mit.edu	37	chr19	38126325	38126325	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaccagtatgtattctctGatggagagttagatgatagc	11	14	10	6	0	2	4	1	2	1	2	3	5	2	4	1	1	1	3	1	1	4	6			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:38126325G>C	uc002ogv.1	-	6	1633	c.1117C>G	c.(1117-1119)CAG>GAG	p.Q373E	ZFP30_uc002ogw.1_Missense_Mutation_p.Q373E|ZFP30_uc002ogx.1_Missense_Mutation_p.Q373E|ZFP30_uc010xtt.1_Missense_Mutation_p.Q372E	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	373	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTATTCTCTGATGGAGAGTT	0.408													4	137					0	0	0	0	C	38126325	C	C	38126325	3	2	56	1	0	0	0	0	1	0	0	0	17711	1299	45	2	446	2	ZFP30	19	38126325	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	5202673	38126325	21002658	56	11202											
ACTN4	81	broad.mit.edu	37	chr19	39200969	39200969	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcttctaccatgccttttCaggagcgcagaaggtaccga	10	9	10	12	2	2	1	1	0	1	1	2	3	2	2	3	2	5	3	3	2	3	5			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:39200969C>G	uc002oja.1	+	8	865	c.806C>G	c.(805-807)TCA>TGA	p.S269*	ACTN4_uc010egc.1_Nonsense_Mutation_p.S269*	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	269	Actin-binding.|CH 2.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CATGCCTTTTCAGGAGCGCAG	0.607													4	218					0	0	0	0	G	39200969	G	G	39200969	4	3	56	1	0	0	0	0	0	1	0	0	207	838	29	2	836	2	ACTN4	19	39200969	Nonsense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	1074644	39200969	19928014	57	11203											
CACNG8	59283	broad.mit.edu	37	chr19	54466602	54466602	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgacgggaccccccaccgcgGgggcggcggcgcctcggaga	5	1	18	17	8	0	1	0	0	0	1	1	4	0	2	5	6	0	0	5	6	0	0			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:54466602G>A	uc002qcs.1	+	1	309	c.203G>A	c.(202-204)GGG>GAG	p.G68E		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	69					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		CCCCACCGCGGGGGCGGCGGC	0.716													3	14					0	0	0	0	A	54466602	A	A	54466602	3	1	56	1	0	0	0	0	1	0	0	0	2575	1232	43	4	208	4	CACNG8	19	54466602	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	15265633	54466602	4662381	58	11204											
LILRA2	11027	broad.mit.edu	37	chr19	55085362	55085362	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccatgacccccatcctcaCggtcctgatctgtctcggtg	5	10	9	17	3	3	2	1	2	2	0	6	2	5	2	5	2	0	0	5	2	0	0	rs145704089	byFrequency	TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:55085362C>T	uc002qgg.3	+	1	106	c.17C>T	c.(16-18)ACG>ATG	p.T6M	LILRA2_uc010ern.2_Missense_Mutation_p.T6M|LILRA2_uc002qgf.2_Missense_Mutation_p.T6M|LILRA2_uc010yfe.1_Missense_Mutation_p.T6M|LILRA2_uc010yff.1_Missense_Mutation_p.T6M|LILRA2_uc010ero.2_Missense_Mutation_p.T6M|LILRA2_uc010yfg.1_Missense_Mutation_p.T6M	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	6					defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CCCATCCTCACGGTCCTGATC	0.602													13	159					0	0	0	0	T	55085362	T	T	55085362	3	4	56	1	0	0	0	0	1	0	0	0	8826	536	19	1	19	1	LILRA2	19	55085362	Missense_Mutation	SNP	C	TCGA-CN-5358-01A-01D-1512-08	618760	55085362	4043621	59	11205											
NEURL2	140825	broad.mit.edu	37	chr20	44519216	44519216	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tggttccacgaggagggttgGaggtcggctgggggccgctg	4	8	21	8	3	0	0	0	0	0	0	2	3	1	2	2	8	0	4	2	8	0	2			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr20:44519216G>C	uc002xqg.1	-	1	686	c.415C>G	c.(415-417)CCA>GCA	p.P139A	C20orf165_uc002xqf.2_5'Flank|CTSA_uc002xqh.2_5'Flank|CTSA_uc002xqj.3_5'Flank|CTSA_uc002xqi.2_5'Flank|CTSA_uc010zxi.1_5'Flank|CTSA_uc002xqk.3_5'Flank	NM_080749	NP_542787	Q9BR09	NEUL2_HUMAN	neuralized-like protein 2	139	NHR.				intracellular signal transduction						0		Myeloproliferative disorder(115;0.0122)				AGGAGGGTTGGAGGTCGGCTG	0.697													6	54					0	0	0	0	C	44519216	C	C	44519216	3	2	56	1	0	0	0	0	1	0	0	0	10400	1174	41	2	450	2	NEURL2	20	44519216	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08		44519216	18506304	60	11206											
CELSR1	9620	broad.mit.edu	37	chr22	46777939	46777939	+	Frame_Shift_Del	DEL	G	-	-																															ccggccagccggcctcagcaGggggccttctgcaatgtgag																										TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr22:46777939delG	uc003bhw.1	-	21	6892	c.6892delC	c.(6892-6894)CTGfs	p.L2298fs	CELSR1_uc011arc.1_Frame_Shift_Del_p.L619fs	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2298	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GGCCTCAGCAGGGGGCCTTCT	0.667													---	---	---								-	46777939	-	-	46777939	7	5	56	1	0	1	0	1	0	0	0	0	3236	991	35	0	2212	0	CELSR1	22	46777939	Frame_Shift_Del	DEL	G	TCGA-CN-5358-01A-01D-1512-08		46777939	4526627	61	11207											
USP9X	8239	broad.mit.edu	37	chrX	41000632	41000632	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtgtatcatactatactcAtcgacatggtaatcctgagg	12	13	8	8	1	2	1	2	1	0	0	4	2	3	1	1	2	2	2	1	2	6	6			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chrX:41000632A>G	uc004dfb.2	+	9	1742	c.1109A>G	c.(1108-1110)CAT>CGT	p.H370R	USP9X_uc004dfc.2_Missense_Mutation_p.H370R	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	370					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TACTATACTCATCGACATGGT	0.353													7	33					0	0	0	0	G	41000632	G	G	41000632	3	3	56	1	0	0	0	0	1	0	0	0	17158	217	8	5	1139	5	USP9X	23	41000632	Missense_Mutation	SNP	A	TCGA-CN-5358-01A-01D-1512-08		41000632	114269928	62	11208											
CACNA1F	778	broad.mit.edu	37	chrX	49065126	49065126	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggagccccggcgagctgaggGctgggagaccatcgtggcct	6	5	18	12	3	0	2	0	1	0	1	1	5	0	3	4	5	2	2	4	5	0	0			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chrX:49065126G>A	uc004dnb.2	-	43	5067	c.5005C>T	c.(5005-5007)CCC>TCC	p.P1669S	CACNA1F_uc010nip.2_Missense_Mutation_p.P1658S	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1669	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CGAGCTGAGGGCTGGGAGACC	0.567													3	55					0	0	0	0	A	49065126	A	A	49065126	3	1	56	1	0	0	0	0	1	0	0	0	2555	1203	42	4	952	4	CACNA1F	23	49065126	Missense_Mutation	SNP	G	TCGA-CN-5358-01A-01D-1512-08	8064494	49065126	106205434	63	11209											
CAMTA1	23261	broad.mit.edu	37	chr1	7805922	7805922	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagtgcatataacgagcCtctaaccccttcttctaata	13	11	5	12	1	3	1	0	0	3	1	3	2	3	1	3	0	4	1	3	0	6	7			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:7805922C>G	uc001aoi.2	+	18	4595	c.4388C>G	c.(4387-4389)CCT>CGT	p.P1463R	CAMTA1_uc001aok.3_Missense_Mutation_p.P506R|CAMTA1_uc001aoj.2_Missense_Mutation_p.P419R|CAMTA1_uc009vmf.2_Intron	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TATAACGAGCCTCTAACCCCT	0.458													40	247					0	0	0	0	G	7805922	G	G	7805922	3	3	57	1	0	0	0	0	1	0	0	0	2625	681	24	4	4458	4	CAMTA1	1	7805922	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08		7805922	241444699	1	11210											
GRHL3	57822	broad.mit.edu	37	chr1	24669215	24669215	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagatgcgcgatgacgagcGgaagcagttccggaggaagg	12	4	18	7	5	0	2	0	1	0	1	1	8	1	5	1	4	3	2	1	4	3	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:24669215G>A	uc001biy.2	+	10	1299	c.1253G>A	c.(1252-1254)CGG>CAG	p.R418Q	GRHL3_uc001bix.2_Missense_Mutation_p.R413Q|GRHL3_uc001biz.2_Missense_Mutation_p.R320Q	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	413					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GATGACGAGCGGAAGCAGTTC	0.627													16	191					0	0	0	0	A	24669215	A	A	24669215	3	1	57	1	0	0	0	0	1	0	0	0	6804	1116	39	1	1312	1	GRHL3	1	24669215	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	16863293	24669215	224581406	2	11211											
RCC1	1104	broad.mit.edu	37	chr1	28862414	28862414	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccccaagtgtgtgatgctGaaatccaggggaagccgggg	9	7	16	9	1	0	2	0	2	0	0	2	3	2	3	4	4	2	1	4	4	3	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:28862414G>A	uc001bqg.1	+	7	778	c.693G>A	c.(691-693)CTG>CTA	p.L231L	SNHG3-RCC1_uc001bqa.1_Silent_p.L231L|SNHG3-RCC1_uc001bqb.1_Silent_p.L231L|SNHG3-RCC1_uc001bqc.1_Silent_p.L231L|RCC1_uc001bqe.1_Silent_p.L248L|RCC1_uc001bqf.1_Silent_p.L262L	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	231	RCC1 4.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GTGTGATGCTGAAATCCAGGG	0.562													24	261					0	0	0	0	A	28862414	A	A	28862414	2	1	57	1	0	0	0	0	0	0	0	1	13238	1277	45	2		2	RCC1	1	28862414	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	4193199	28862414	220388207	3	11212											
NRD1	4898	broad.mit.edu	37	chr1	52289446	52289446	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttggctcatgcttgagcGtctcagcatttcctataaaa	9	15	7	10	1	3	1	2	1	2	0	5	1	4	1	1	1	3	3	1	1	3	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:52289446G>A	uc001ctc.3	-	9	1575	c.1253C>T	c.(1252-1254)ACG>ATG	p.T418M	NRD1_uc009vzb.2_Missense_Mutation_p.T113M|NRD1_uc001ctd.3_Missense_Mutation_p.T350M|NRD1_uc001cte.2_Missense_Mutation_p.T286M|NRD1_uc001ctf.2_Missense_Mutation_p.T350M|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.T218M	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	349					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						ATGCTTGAGCGTCTCAGCATT	0.313													6	84					0	0	0	0	A	52289446	A	A	52289446	3	1	57	1	0	0	0	0	1	0	0	0	10699	1145	40	1	2506	1	NRD1	1	52289446	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	23427032	52289446	196961175	4	11213											
LRRC42	115353	broad.mit.edu	37	chr1	54417937	54417937	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcggtactccgccaaatccCtcttcagccttgtcctgggt	5	13	8	15	2	2	0	1	0	1	0	6	0	5	0	5	2	2	1	5	2	2	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:54417937C>T	uc001cwj.1	+	2	465	c.265C>T	c.(265-267)CTC>TTC	p.L89F	LRRC42_uc001cwl.1_Missense_Mutation_p.L89F|LRRC42_uc001cwk.1_Missense_Mutation_p.L89F|LRRC42_uc009vzm.1_Missense_Mutation_p.L89F	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	89											0						CGCCAAATCCCTCTTCAGCCT	0.483													13	168					0	0	0	0	T	54417937	T	T	54417937	3	4	57	1	0	0	0	0	1	0	0	0	9050	681	24	4	267	4	LRRC42	1	54417937	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	2128491	54417937	194832684	5	11214											
BCL10	8915	broad.mit.edu	37	chr1	85733597	85733597	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagagaaattactctcatCtgaatttgatctggagaggt	12	14	9	6	0	4	4	2	2	3	2	5	6	4	4	0	2	1	0	0	2	3	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:85733597C>T	uc001dkz.2	-	4	1120	c.415G>A	c.(415-417)GAT>AAT	p.D139N		NM_003921	NP_003912	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	139					apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			lung(2)	2				all cancers(265;0.0114)|Epithelial(280;0.0311)		TTACTCTCATCTGAATTTGAT	0.388			T	IGH@	MALT 								28	184					0	0	0	0	T	85733597	T	T	85733597	3	4	57	1	0	0	0	0	1	0	0	0	1364	913	32	2	290	2	BCL10	1	85733597	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	31315660	85733597	163517024	6	11215											
UBAP2L	9898	broad.mit.edu	37	chr1	154199771	154199771	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctaggccactgcagaacAaattagacttgcacagatga	14	9	8	10	0	0	4	0	1	0	3	1	4	1	4	2	1	3	2	2	1	4	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:154199771A>C	uc001fep.3	+	3	271	c.104A>C	c.(103-105)CAA>CCA	p.Q35P	UBAP2L_uc009wot.2_Missense_Mutation_p.Q35P|UBAP2L_uc010pek.1_Missense_Mutation_p.Q34P|UBAP2L_uc010pel.1_Missense_Mutation_p.Q34P|UBAP2L_uc001fen.1_Missense_Mutation_p.Q34P|UBAP2L_uc010pem.1_Missense_Mutation_p.Q34P|UBAP2L_uc010pen.1_5'Flank	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	35					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACTGCAGAACAAATTAGACTT	0.418													17	187					0	0	0	0	C	154199771	C	C	154199771	3	2	57	1	0	0	0	0	1	0	0	0	16906	130	5	5	110	5	UBAP2L	1	154199771	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	68466174	154199771	95050850	7	11216											
OR10J3	441911	broad.mit.edu	37	chr1	159283758	159283758	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttcttctgaccttcagctGaggcaatcttaagaatggtg	9	13	9	10	0	4	3	1	2	3	1	4	3	4	3	2	2	1	2	2	2	3	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:159283758G>A	uc010piu.1	-	1	692	c.692C>T	c.(691-693)TCA>TTA	p.S231L		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					ACCTTCAGCTGAGGCAATCTT	0.493													38	138					0	0	0	0	A	159283758	A	A	159283758	3	1	57	1	0	0	0	0	1	0	0	0	10965	1294	45	2	299	2	OR10J3	1	159283758	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	5083987	159283758	89966863	8	11217											
SLAMF8	56833	broad.mit.edu	37	chr1	159802746	159802746	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaagacctgccaggttttcTtgtcctgttgggcccccaac	6	11	9	15	0	1	1	0	0	1	1	2	1	2	1	6	2	2	2	6	2	2	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:159802746T>A	uc001fue.3	+	3	658	c.448T>A	c.(448-450)TTG>ATG	p.L150M		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor	150	Ig-like C2-type.|Extracellular (Potential).					integral to membrane					0	all_hematologic(112;0.0597)					CCAGGTTTTCTTGTCCTGTTG	0.532													15	148					0	0	0	0	A	159802746	A	A	159802746	3	1	57	1	0	0	0	0	1	0	0	0	14435	1606	56	5	458	5	SLAMF8	1	159802746	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	518988	159802746	89447875	9	11218											
BLZF1	8548	broad.mit.edu	37	chr1	169349768	169349768	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagcagctttacagcgtcaaAaccgtgatgcacacggggct	11	7	12	11	3	1	1	1	1	0	0	1	2	1	1	1	2	6	4	1	2	3	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:169349768A>T	uc001gfx.1	+	5	1155	c.718A>T	c.(718-720)AAC>TAC	p.N240Y	BLZF1_uc001gfy.2_Missense_Mutation_p.N240Y|BLZF1_uc009wvp.1_Missense_Mutation_p.N217Y	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	240					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					ACAGCGTCAAAACCGTGATGC	0.393													7	106					0	0	0	0	T	169349768	T	T	169349768	3	4	57	1	0	0	0	0	1	0	0	0	1456	14	1	5	732	5	BLZF1	1	169349768	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	9547022	169349768	79900853	10	11219											
RD3	343035	broad.mit.edu	37	chr1	211654485	211654485	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggatagcaggcccacaataGgatgggtggatcttaacgca	13	7	13	8	1	1	0	0	0	1	0	1	3	1	3	1	5	2	2	1	5	4	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:211654485G>A	uc001him.2	-	2	1437	c.273C>T	c.(271-273)TCC>TCT	p.S91S	RD3_uc001hin.2_RNA|RD3_uc009xda.2_Intron	NM_183059	NP_898882	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	91					response to stimulus|visual perception					ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		GCCCACAATAGGATGGGTGGA	0.617													17	45					0	0	0	0	A	211654485	A	A	211654485	2	1	57	1	0	0	0	0	0	0	0	1	13252	987	35	4		4	RD3	1	211654485	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	42304717	211654485	37596136	11	11220											
USH2A	7399	broad.mit.edu	37	chr1	216348688	216348688	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatcatcgtggtcatcagAgctggtagagatgactctct	9	13	10	9	1	5	3	4	1	1	2	7	4	5	3	0	2	1	2	0	2	1	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:216348688A>T	uc001hku.1	-	21	4920	c.4533T>A	c.(4531-4533)GCT>GCA	p.A1511A	USH2A_uc001hkv.2_Silent_p.A1511A	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1511	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTCATCAGAGCTGGTAGAG	0.443										HNSCC(13;0.011)			7	90					0	0	0	0	T	216348688	T	T	216348688	2	4	57	1	0	0	0	0	0	0	0	1	17104	291	11	5		5	USH2A	1	216348688	Silent	SNP	A	TCGA-CN-5359-01A-01D-1434-08	4694203	216348688	32901933	12	11221											
OBSCN	84033	broad.mit.edu	37	chr1	228465484	228465484	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactctcatctaccggagaGtcctggcggaagatgcagga	11	7	12	11	2	2	2	1	0	2	2	4	5	3	4	2	4	2	1	2	4	2	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:228465484G>C	uc009xez.1	+	25	6828	c.6784G>C	c.(6784-6786)GTC>CTC	p.V2262L	OBSCN_uc001hsn.2_Missense_Mutation_p.V2262L|OBSCN_uc001hsp.1_5'UTR|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2262					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTACCGGAGAGTCCTGGCGGA	0.622													7	62					0	0	0	0	C	228465484	C	C	228465484	3	2	57	1	0	0	0	0	1	0	0	0	10866	1029	36	4	6878	4	OBSCN	1	228465484	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	12116796	228465484	20785137	13	11222											
CAPN9	10753	broad.mit.edu	37	chr1	230898463	230898463	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgcccaccttcagggaccGcttggttttcctccactctg	4	12	8	17	1	2	0	1	0	1	0	4	1	4	1	6	2	1	2	6	2	0	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr1:230898463G>A	uc001htz.1	+	4	580	c.467G>A	c.(466-468)CGC>CAC	p.R156H	CAPN9_uc009xfg.1_Missense_Mutation_p.R93H|CAPN9_uc001hua.1_Missense_Mutation_p.R156H	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	156	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				TTCAGGGACCGCTTGGTTTTC	0.577													28	87					0	0	0	0	A	230898463	A	A	230898463	3	1	57	1	0	0	0	0	1	0	0	0	2644	1087	38	1	481	1	CAPN9	1	230898463	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	2432979	230898463	18352158	14	11223											
ITSN2	50618	broad.mit.edu	37	chr2	24432687	24432687	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagacgcgtgatactcacCgttttatacattttgaattg	10	14	7	10	3	1	3	1	2	0	1	1	3	1	3	2	0	2	1	2	0	4	7			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:24432687C>T	uc002rfe.2	-	35	4731	c.4473G>A	c.(4471-4473)ACG>ACA	p.T1491T	ITSN2_uc002rff.2_Silent_p.T1464T	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1491	PH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATACTCACCGTTTTATACA	0.502													5	108					0	0	0	0	T	24432687	T	T	24432687	2	4	57	1	0	0	0	0	0	0	0	1	7966	666	23	1		1	ITSN2	2	24432687	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08		24432687	218766686	15	11224											
RASGRP3	25780	broad.mit.edu	37	chr2	33784037	33784037	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctggtgtggatgttgtagaCcggggcacggagtttgaact	7	11	17	6	2	0	2	0	1	0	1	0	4	0	4	1	5	1	5	1	5	2	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:33784037C>T	uc002rox.2	+	18	2631	c.2004C>T	c.(2002-2004)GAC>GAT	p.D668D	RASGRP3_uc010ync.1_Silent_p.D668D|RASGRP3_uc002roy.2_Silent_p.D667D	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	668					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					ATGTTGTAGACCGGGGCACGG	0.483													9	36					0	0	0	0	T	33784037	T	T	33784037	2	4	57	1	0	0	0	0	0	0	0	1	13141	506	18	4		4	RASGRP3	2	33784037	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	9351350	33784037	209415336	16	11225											
RHOQ	23433	broad.mit.edu	37	chr2	46803235	46803235	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgttcctcaggaagactatGaccgtctgaggcctttatct	8	14	9	10	1	3	3	1	2	2	1	4	4	4	4	3	2	0	1	3	2	3	5			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:46803235G>A	uc002rva.2	+	3	530	c.211G>A	c.(211-213)GAC>AAC	p.D71N	uc002rvb.2_Intron	NM_012249	NP_036381	P17081	RHOQ_HUMAN	ras-like protein TC10 precursor	71					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GGAAGACTATGACCGTCTGAG	0.373													11	113					0	0	0	0	A	46803235	A	A	46803235	3	1	57	1	0	0	0	0	1	0	0	0	13407	1290	45	2	221	2	RHOQ	2	46803235	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	13019198	46803235	196396138	17	11226											
EPCAM	4072	broad.mit.edu	37	chr2	47602414	47602414	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acacaaagcaagagaaaaacCttatgatagtaaaagtttgc	20	8	7	6	0	0	2	0	1	0	1	0	3	0	2	1	0	3	3	1	0	8	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:47602414C>A	uc002rvx.2	+	4	825	c.467C>A	c.(466-468)CCT>CAT	p.P156H	EPCAM_uc002rvw.2_Missense_Mutation_p.P184H|MIR559_hsa-mir-559|MI0003565_5'Flank	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	156	Extracellular (Potential).				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						AGAGAAAAACCTTATGATAGT	0.348									Lynch_syndrome				15	56					3.51602e-12	4.33509e-12	1	0	A	47602414	A	A	47602414	3	1	57	1	0	0	0	0	1	0	0	0	5186	681	24	4	481	4	EPCAM	2	47602414	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	799179	47602414	195596959	18	11227											
ACTG2	72	broad.mit.edu	37	chr2	74129609	74129609	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaccaactgggatgacatGgagaaggtatctgtagactt	13	10	11	7	0	2	3	1	1	1	2	2	5	2	4	1	3	1	2	1	3	4	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:74129609G>A	uc002sjw.2	+	3	371	c.249G>A	c.(247-249)ATG>ATA	p.M83I	ACTG2_uc010fex.1_Missense_Mutation_p.M83I|ACTG2_uc010fey.2_Missense_Mutation_p.M83I|ACTG2_uc010yrn.1_Intron	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	83					muscle contraction	cytoskeleton|cytosol	ATP binding				0						GGGATGACATGGAGAAGGTAT	0.453													11	61					0	0	0	0	A	74129609	A	A	74129609	3	1	57	1	0	0	0	0	1	0	0	0	197	1348	47	4	255	4	ACTG2	2	74129609	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	26527195	74129609	169069764	19	11228											
MGAT4A	11320	broad.mit.edu	37	chr2	99279521	99279521	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataattacctctcctatgaaGactactataacacagtccaa	16	11	3	11	0	1	2	0	1	1	1	3	2	2	2	3	0	3	0	3	0	8	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:99279521G>T	uc002sze.2	-	5	839	c.525C>A	c.(523-525)GTC>GTA	p.V175V	MGAT4A_uc010yvm.1_Silent_p.V47V|MGAT4A_uc010fil.2_5'UTR|MGAT4A_uc010fim.1_Silent_p.V47V	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	175	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						CTCCTATGAAGACTACTATAA	0.303													29	268					0.000184323	0.000203037	1	0	T	99279521	T	T	99279521	2	4	57	1	0	0	0	0	0	0	0	1	9598	929	33	2		2	MGAT4A	2	99279521	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	25149912	99279521	143919852	20	11229											
LRP1B	53353	broad.mit.edu	37	chr2	141081587	141081587	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccatttttaggtcctgctCcatatatataatcttcaaag	12	15	4	10	0	2	0	1	0	1	0	4	0	4	0	3	1	1	1	3	1	6	8			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:141081587C>T	uc002tvj.1	-	81	13361	c.12389G>A	c.(12388-12390)GGA>GAA	p.G4130E		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4130	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGGTCCTGCTCCATATATATA	0.299										TSP Lung(27;0.18)			8	150					0	0	0	0	T	141081587	T	T	141081587	3	4	57	1	0	0	0	0	1	0	0	0	9005	855	30	2	1454	2	LRP1B	2	141081587	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	41802066	141081587	102117786	21	11230											
RIF1	55183	broad.mit.edu	37	chr2	152324520	152324520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgtgttttcaggttcgcCgtgtctcctttgcagatcca	5	15	9	12	2	2	1	1	0	1	1	5	1	3	1	4	1	1	3	4	1	0	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:152324520C>T	uc002txm.2	+	31	6737	c.6607C>T	c.(6607-6609)CGT>TGT	p.R2203C	RIF1_uc002txl.2_Missense_Mutation_p.R2203C|RIF1_uc002txn.2_Missense_Mutation_p.R2203C|RIF1_uc002txo.2_Missense_Mutation_p.R2203C|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	2203	Interaction with condensed chromosomes in telophase.				cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TCAGGTTCGCCGTGTCTCCTT	0.358													25	165					0	0	0	0	T	152324520	T	T	152324520	3	4	57	1	0	0	0	0	1	0	0	0	13424	652	23	1	6725	1	RIF1	2	152324520	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	11242933	152324520	90874853	22	11231											
WIPF1	7456	broad.mit.edu	37	chr2	175450340	175450340	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacagtcttgctgataaatCtggaaaaacaagaatgcgat	17	9	8	7	1	2	2	0	1	2	1	2	4	2	3	0	1	4	1	0	1	7	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:175450340C>T	uc002uiy.2	-	3	295	c.-37_splice	c.e3-1		uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Splice_Site|WIPF1_uc010fqt.1_Splice_Site|WIPF1_uc002ujc.1_Splice_Site|WIPF1_uc002uiz.2_Splice_Site|WIPF1_uc002ujb.1_Splice_Site|WIPF1_uc010zep.1_Splice_Site	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1						actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						GCTGATAAATCTGGAAAAACA	0.493													8	57					0	0	0	0	T	175450340	T	T	175450340	5	4	57	1	0	0	0	0	0	0	1	0	17435	927	32	2		2	WIPF1	2	175450340	Splice_Site	SNP	C	TCGA-CN-5359-01A-01D-1434-08	23125820	175450340	67749033	23	11232											
TTN	7273	broad.mit.edu	37	chr2	179638332	179638332	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacggtcatcaggcttgattTgttcatcatttaagtaccac	10	14	7	10	1	4	1	4	1	0	0	4	1	4	1	1	2	1	3	1	2	2	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:179638332T>G	uc010zfg.1	-	32	7675	c.7451A>C	c.(7450-7452)CAA>CCA	p.Q2484P	TTN_uc010zfh.1_Missense_Mutation_p.Q2438P|TTN_uc010zfi.1_Missense_Mutation_p.Q2438P|TTN_uc010zfj.1_Missense_Mutation_p.Q2438P|TTN_uc002unb.2_Missense_Mutation_p.Q2484P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2484							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGCTTGATTTGTTCATCATT	0.428													14	185					0	0	0	0	G	179638332	G	G	179638332	3	3	57	1	0	0	0	0	1	0	0	0	16803	1812	63	5	103861	5	TTN	2	179638332	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	4187992	179638332	63561041	24	11233											
TTN	7273	broad.mit.edu	37	chr2	179650801	179650801	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccaggctctctgggctctCtgactcgggcctggtctact	3	11	12	15	1	3	1	0	1	3	0	6	1	3	1	2	4	1	2	2	4	1	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:179650801C>G	uc010zfg.1	-	14	2368	c.2144G>C	c.(2143-2145)AGA>ACA	p.R715T	TTN_uc010zfh.1_Missense_Mutation_p.R669T|TTN_uc010zfi.1_Missense_Mutation_p.R669T|TTN_uc010zfj.1_Missense_Mutation_p.R669T|TTN_uc002unb.2_Missense_Mutation_p.R715T|TTN_uc010frg.1_Missense_Mutation_p.R297T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	715							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGGGCTCTCTGACTCGGGC	0.502													8	85					0	0	0	0	G	179650801	G	G	179650801	3	3	57	1	0	0	0	0	1	0	0	0	16803	913	32	2	109240	2	TTN	2	179650801	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	12469	179650801	63548572	25	11234											
ZNF804A	91752	broad.mit.edu	37	chr2	185803488	185803488	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccgcagctgcaggaacctTtaaagtgcttcagccacacc	11	7	9	14	1	1	0	1	0	0	0	1	1	1	1	4	1	6	4	4	1	3	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr2:185803488T>A	uc002uph.2	+	4	3959	c.3365T>A	c.(3364-3366)TTT>TAT	p.F1122Y		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1122						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						gcagGAACCTTTAAAGTGCTT	0.348													7	70					0	0	0	0	A	185803488	A	A	185803488	3	1	57	1	0	0	0	0	1	0	0	0	18237	1841	64	5	3379	5	ZNF804A	2	185803488	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	6152687	185803488	57395885	26	11235											
RNF123	63891	broad.mit.edu	37	chr3	49758486	49758487	+	Frame_Shift_Ins	INS	-	A	A																															ggacctctgccccatctgctINSatgcccaccccatctctgct																										TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:49758486_49758487insA	uc003cxh.2	+	38	3858_3859	c.3772_3773insA	c.(3772-3774)TATfs	p.Y1258fs	RNF123_uc003cxi.2_RNA|AMIGO3_uc003cxj.2_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	1258	RING-type.					cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CCCCATCTGCTATGCCCACCCC	0.604													---	---	---								A	49758487	A	A	49758486	7	5	57	1	0	1	1	0	0	0	0	0	13498	1522	53	0	3918	0	RNF123	3	49758486	Frame_Shift_Ins	INS	-	TCGA-CN-5359-01A-01D-1434-08		49758486	148263944	27	11236											
OR5AC2	81050	broad.mit.edu	37	chr3	97806357	97806357	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccagtgcaactacagaatGcttcctcctggtgatgatgg	9	12	10	10	0	0	3	0	2	0	1	3	3	3	3	3	2	4	2	3	2	3	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:97806357G>T	uc011bgs.1	+	1	341	c.341G>T	c.(340-342)TGC>TTC	p.C114F		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ACTACAGAATGCTTCCTCCTG	0.448													23	380					9.62636e-23	1.2434e-22	1	0	T	97806357	T	T	97806357	3	4	57	1	0	0	0	0	1	0	0	0	11195	1319	46	4	343	4	OR5AC2	3	97806357	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	48047871	97806357	100216073	28	11237											
PRR23A	729627	broad.mit.edu	37	chr3	138724783	138724783	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcctgcgctcctgagcgttCgtcgacagagctcaggagga	7	8	14	12	4	1	2	1	1	0	1	5	5	3	4	2	2	3	3	2	2	0	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:138724783C>T	uc011bms.1	-	1	328	c.328G>A	c.(328-330)GAA>AAA	p.E110K		NM_001134659	NP_001128131	A6NEV1	PR23A_HUMAN	proline rich 23A	110											0						CCTGAGCGTTCGTCGACAGAG	0.617													6	42					0	0	0	0	T	138724783	T	T	138724783	3	4	57	1	0	0	0	0	1	0	0	0	12656	893	31	1	476	1	PRR23A	3	138724783	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	40918426	138724783	59297647	29	11238											
HPS3	84343	broad.mit.edu	37	chr3	148880620	148880620	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacatctggagattgtctaaGaggcagcctcctgacaccac	11	9	9	12	0	2	3	0	1	2	2	3	4	3	3	3	2	2	1	3	2	2	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:148880620G>C	uc003ewu.1	+	13	2576	c.2436G>C	c.(2434-2436)AAG>AAC	p.K812N	CP_uc011bnr.1_RNA|HPS3_uc011bnq.1_Missense_Mutation_p.K647N|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	812						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GATTGTCTAAGAGGCAGCCTC	0.423									Hermansky-Pudlak_syndrome				22	152					0	0	0	0	C	148880620	C	C	148880620	3	2	57	1	0	0	0	0	1	0	0	0	7379	933	33	2	2486	2	HPS3	3	148880620	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	10155837	148880620	49141810	30	11239											
DHX36	170506	broad.mit.edu	37	chr3	154022955	154022955	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccctgtttccttggcaacCgactgtgaatgaaagacatg	12	10	9	10	1	0	3	0	2	0	1	1	4	1	3	3	1	2	2	3	1	4	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:154022955C>T	uc003ezy.3	-	7	977	c.896G>A	c.(895-897)CGG>CAG	p.R299Q	DHX36_uc010hvq.2_Missense_Mutation_p.R299Q|DHX36_uc003ezz.3_Missense_Mutation_p.R299Q	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	299	Helicase ATP-binding.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CCTTGGCAACCGACTGTGAAT	0.353													4	79					0	0	0	0	T	154022955	T	T	154022955	3	4	57	1	0	0	0	0	1	0	0	0	4531	652	23	1	2206	1	DHX36	3	154022955	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	5142335	154022955	43999475	31	11240											
NCEH1	57552	broad.mit.edu	37	chr3	172365794	172365794	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaccatcaaagtctgtgtcGgtcaccttcacttgggcaga	10	10	9	12	1	4	1	3	0	1	1	5	1	4	1	2	2	0	1	2	2	1	2	rs141870427	byFrequency	TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:172365794G>C	uc011bpx.1	-	2	483	c.345C>G	c.(343-345)ACC>ACG	p.T115T	NCEH1_uc003fig.2_Silent_p.T115T|NCEH1_uc011bpw.1_5'UTR|NCEH1_uc011bpy.1_Intron	NM_001146276	NP_001139748	Q6PIU2	NCEH1_HUMAN	arylacetamide deacetylase-like 1 isoform a	83	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity				0						AGTCTGTGTCGGTCACCTTCA	0.512													4	124					0	0	0	0	C	172365794	C	C	172365794	2	2	57	1	0	0	0	0	0	0	0	1	10269	1103	39	3		3	NCEH1	3	172365794	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	18342839	172365794	25656636	32	11241											
CLCN2	1181	broad.mit.edu	37	chr3	184071144	184071144	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccgccggcgggctgggCtcagctgggcccccaacaat	5	5	15	16	3	1	0	1	0	0	0	1	0	1	0	4	4	3	4	4	4	2	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:184071144C>T	uc003foi.2	-	17	2046	c.1922G>A	c.(1921-1923)AGC>AAC	p.S641N	CLCN2_uc003foh.2_Missense_Mutation_p.S165N|CLCN2_uc010hya.1_Missense_Mutation_p.S624N|CLCN2_uc011brl.1_Missense_Mutation_p.S641N|CLCN2_uc011brm.1_Missense_Mutation_p.S597N	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	641	Cytoplasmic (By similarity).|CBS 1.					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	GCGGGCTGGGCTCAGCTGGGC	0.627													16	79					0	0	0	0	T	184071144	T	T	184071144	3	4	57	1	0	0	0	0	1	0	0	0	3478	797	28	4	806	4	CLCN2	3	184071144	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	11705350	184071144	13951286	33	11242											
ATP13A3	79572	broad.mit.edu	37	chr3	194182898	194182898	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttgaccctgattgatggTcttcctttcttccctgtcca	4	18	6	13	0	3	3	0	3	3	0	6	3	6	3	4	1	0	0	4	1	0	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr3:194182898T>C	uc003fty.3	-	2	424	c.22A>G	c.(22-24)ACC>GCC	p.T8A		NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	8					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TGATTGATGGTCTTCCTTTCT	0.408													10	138					0	0	0	0	C	194182898	C	C	194182898	3	2	57	1	0	0	0	0	1	0	0	0	1127	1667	58	5	3782	5	ATP13A3	3	194182898	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	10111754	194182898	3839532	34	11243											
BST1	683	broad.mit.edu	37	chr4	15716972	15716972	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcagagccaacaggagcctAtcccatcaaagggtaagaac	15	6	9	11	0	2	2	2	0	0	2	3	3	3	3	3	2	4	1	3	2	5	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:15716972A>G	uc003goh.3	+	5	794	c.599A>G	c.(598-600)TAT>TGT	p.Y200C	BST1_uc003goi.2_Missense_Mutation_p.Y11C	NM_004334	NP_004325	Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1 precursor	200					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)	1						ACAGGAGCCTATCCCATCAAA	0.368													13	76					0	0	0	0	G	15716972	G	G	15716972	3	3	57	1	0	0	0	0	1	0	0	0	1538	449	16	5	617	5	BST1	4	15716972	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08		15716972	175437304	35	11244											
UGT2B10	7365	broad.mit.edu	37	chr4	69885646	69885646	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagctcaccacagggtaaatAagcatctgcaaaaacgatgt	16	7	8	10	1	2	0	1	0	1	0	2	1	2	0	1	1	4	4	1	1	5	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:69885646A>C	uc011cao.1	-	4	479	c.343T>G	c.(343-345)TAT>GAT	p.Y115D	UGT2B10_uc011can.1_Missense_Mutation_p.Y115D			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	152					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						CAGGGTAAATAAGCATCTGCA	0.378													13	147					0	0	0	0	C	69885646	C	C	69885646	3	2	57	1	0	0	0	0	1	0	0	0	17024	372	13	5	2767	5	UGT2B10	4	69885646	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	54168674	69885646	121268630	36	11245											
SULT1E1	6783	broad.mit.edu	37	chr4	70713474	70713474	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gactctttcccttttcccacCaagattttacatgtttatac	9	17	3	12	0	1	1	0	0	1	1	3	2	3	1	3	0	2	1	3	0	4	8			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:70713474C>G	uc003heo.2	-	6	646	c.533G>C	c.(532-534)TGG>TCG	p.W178S		NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	178					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1						CTTTTCCCACCAAGATTTTAC	0.373													50	129					0	0	0	0	G	70713474	G	G	70713474	3	3	57	1	0	0	0	0	1	0	0	0	15446	595	21	4	363	4	SULT1E1	4	70713474	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	827828	70713474	120440802	37	11246											
GRID2	2895	broad.mit.edu	37	chr4	94006200	94006200	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcagctccattggctgcaCgtcagcaggatccctccagt	7	9	11	14	1	2	0	2	0	0	0	5	1	5	1	3	3	3	4	3	3	0	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:94006200C>T	uc011cdt.1	+	3	557	c.299C>T	c.(298-300)ACG>ATG	p.T100M	GRID2_uc010ikx.2_Missense_Mutation_p.T100M|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	100	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATTGGCTGCACGTCAGCAGGA	0.522													6	99					0	0	0	0	T	94006200	T	T	94006200	3	4	57	1	0	0	0	0	1	0	0	0	6811	536	19	1	309	1	GRID2	4	94006200	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	23292726	94006200	97148076	38	11247											
ADH1B	125	broad.mit.edu	37	chr4	100232742	100232742	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagggtttattgagaggttCtgggaagcaggaggtacccc	10	10	15	6	0	1	1	0	1	1	1	1	4	1	3	2	5	2	4	2	5	4	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:100232742C>T	uc003hus.3	-	7	984	c.900G>A	c.(898-900)CAG>CAA	p.Q300Q	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Silent_p.Q260Q|ADH1B_uc011ceh.1_Silent_p.Q145Q|ADH1B_uc011cei.1_Silent_p.Q260Q	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	300					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	TTGAGAGGTTCTGGGAAGCAG	0.463													19	260					0	0	0	0	T	100232742	T	T	100232742	2	4	57	1	0	0	0	0	0	0	0	1	308	912	32	2		2	ADH1B	4	100232742	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	6226542	100232742	90921534	39	11248											
ADH1A	124	broad.mit.edu	37	chr4	100242501	100242501	+	Translation_Start_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgctcatgtcgtttctgtcTtctctgcccaccagcagact	5	14	8	14	1	4	1	1	0	3	1	6	1	4	1	2	0	3	3	2	0	0	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:100242501T>A	uc011ceg.1	-	1	72	c.-12A>T	c.(-14--10)GAAGA>GATGA		ADH1B_uc003hus.3_Translation_Start_Site|ADH1B_uc003hut.3_Translation_Start_Site|ADH1B_uc011ceh.1_Translation_Start_Site|ADH1B_uc011cei.1_Translation_Start_Site	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit						ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CGTTTCTGTCTTCTCTGCCCA	0.348													39	145					0	0	0	0	A	100242501	A	A	100242501	1	1	57	1	0	0	0	0	0	0	0	0	307	1624	56	5		5	ADH1A	4	100242501	Translation_Start_Site	SNP	T	TCGA-CN-5359-01A-01D-1434-08	9759	100242501	90911775	40	11249											
TBCK	93627	broad.mit.edu	37	chr4	107016640	107016640	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttctgaatatacttaccTcagctgtgtgttttgccaca	9	16	6	10	0	2	1	1	1	1	0	2	1	2	1	2	0	4	2	2	0	4	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:107016640T>A	uc010ilv.2	-	25	2935	c.2570A>T	c.(2569-2571)GAG>GTG	p.E857V	TBCK_uc003hyb.2_Missense_Mutation_p.E600V|TBCK_uc003hye.2_Missense_Mutation_p.E818V|TBCK_uc003hyc.2_Missense_Mutation_p.E794V|TBCK_uc003hyd.2_Missense_Mutation_p.E685V|TBCK_uc003hyf.2_Missense_Mutation_p.E857V	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	857	Rhodanese.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						TATACTTACCTCAGCTGTGTG	0.428													19	90					0	0	0	0	A	107016640	A	A	107016640	3	1	57	1	0	0	0	0	1	0	0	0	15702	1565	54	5	119	5	TBCK	4	107016640	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	6774139	107016640	84137636	41	11250											
ELOVL6	79071	broad.mit.edu	37	chr4	110972591	110972591	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggtacatgagtgaggacCagaagatgttctgaaagtga	14	9	14	4	0	1	7	0	5	1	2	1	8	1	8	1	2	1	2	1	2	3	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:110972591C>A	uc003hzz.2	-	5	827	c.701G>T	c.(700-702)TGG>TTG	p.W234L	ELOVL6_uc003iaa.2_Missense_Mutation_p.W234L	NM_001130721	NP_001124193	Q9H5J4	ELOV6_HUMAN	elongation of very long chain fatty acids-like	234	Helical; (Potential).				fatty acid elongation, saturated fatty acid|long-chain fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process		fatty acid elongase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00462)		GAGTGAGGACCAGAAGATGTT	0.473													13	152					0.00185496	0.00200262	1	0	A	110972591	A	A	110972591	3	1	57	1	0	0	0	0	1	0	0	0	5102	595	21	4	100	4	ELOVL6	4	110972591	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	3955951	110972591	80181685	42	11251											
ANK2	287	broad.mit.edu	37	chr4	114209630	114209630	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagcagggagcaaatgttaaCgcaaaaaccaaggtaaagta	20	5	10	6	1	0	0	0	0	0	0	0	1	0	1	1	2	4	6	1	2	9	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:114209630C>T	uc003ibe.3	+	20	2365	c.2265C>T	c.(2263-2265)AAC>AAT	p.N755N	ANK2_uc003ibd.3_Silent_p.N734N|ANK2_uc003ibf.3_Silent_p.N755N|ANK2_uc003ibc.2_Silent_p.N731N|ANK2_uc011cgb.1_Silent_p.N770N	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	755	ANK 22.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAAATGTTAACGCAAAAACCA	0.373													15	68					0	0	0	0	T	114209630	T	T	114209630	2	4	57	1	0	0	0	0	0	0	0	1	621	535	19	1		1	ANK2	4	114209630	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	3237039	114209630	76944646	43	11252											
USP53	54532	broad.mit.edu	37	chr4	120190943	120190943	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaaacttactttcttcacaAaggaaagatttagagaaggg	18	10	8	5	0	2	2	1	0	1	2	2	4	2	3	0	2	2	0	0	2	7	5			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:120190943A>G	uc003ics.3	+	14	2452	c.1386A>G	c.(1384-1386)CAA>CAG	p.Q462Q	USP53_uc003icr.3_Silent_p.Q462Q|USP53_uc003icu.3_Silent_p.Q85Q|USP53_uc003ict.2_Silent_p.Q85Q	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	462					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						TTTCTTCACAAAGGAAAGATT	0.318													9	163					0	0	0	0	G	120190943	G	G	120190943	2	3	57	1	0	0	0	0	0	0	0	1	17152	11	1	5		5	USP53	4	120190943	Silent	SNP	A	TCGA-CN-5359-01A-01D-1434-08	5981313	120190943	70963333	44	11253											
KIAA1109	84162	broad.mit.edu	37	chr4	123147888	123147888	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcctcttggagtggggacaGacatttgtttttcatgtggt	6	16	13	6	0	2	1	1	0	1	1	2	3	2	3	1	4	1	1	1	4	0	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:123147888G>C	uc003ieh.2	+	22	2865	c.2820G>C	c.(2818-2820)CAG>CAC	p.Q940H	KIAA1109_uc003iei.1_Missense_Mutation_p.Q693H|KIAA1109_uc010ins.1_Missense_Mutation_p.Q283H|KIAA1109_uc003iej.1_3'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	940					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGTGGGGACAGACATTTGTTT	0.413													20	294					0	0	0	0	C	123147888	C	C	123147888	3	2	57	1	0	0	0	0	1	0	0	0	8247	933	33	2	2906	2	KIAA1109	4	123147888	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	2956945	123147888	68006388	45	11254											
FSTL5	56884	broad.mit.edu	37	chr4	162307204	162307204	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtgggcttcagtaaaggAtggttgaaatgccagatcag	11	11	14	5	0	2	2	2	1	0	1	2	3	2	3	1	4	1	3	1	4	3	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:162307204A>G	uc003iqh.2	-	16	2675	c.2239T>C	c.(2239-2241)TCC>CCC	p.S747P	FSTL5_uc003iqi.2_Missense_Mutation_p.S746P|FSTL5_uc010iqv.2_Missense_Mutation_p.S737P|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	747						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TCAGTAAAGGATGGTTGAAAT	0.408													17	142					0	0	0	0	G	162307204	G	G	162307204	3	3	57	1	0	0	0	0	1	0	0	0	6114	333	12	5	308	5	FSTL5	4	162307204	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	39159316	162307204	28847072	46	11255											
FAT1	2195	broad.mit.edu	37	chr4	187541443	187541443	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagcagtgacatagcgaatGacatggcccacctcagtgtc	12	7	10	12	1	1	2	1	2	0	0	2	3	1	2	2	1	2	1	2	1	2	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr4:187541443G>A	uc003izf.2	-	10	6485	c.6297C>T	c.(6295-6297)GTC>GTT	p.V2099V		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2099	Extracellular (Potential).|Cadherin 19.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CATAGCGAATGACATGGCCCA	0.473										HNSCC(5;0.00058)			30	255					0	0	0	0	A	187541443	A	A	187541443	2	1	57	1	0	0	0	0	0	0	0	1	5721	1277	45	2		2	FAT1	4	187541443	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	25234239	187541443	3612833	47	11256											
CTNND2	1501	broad.mit.edu	37	chr5	11364871	11364871	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccctggctctggctgaGactcctcatagggggcttct	4	11	12	14	0	3	1	1	1	2	1	5	2	5	1	3	4	0	3	3	4	1	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:11364871G>T	uc003jfa.1	-	8	1454	c.1309C>A	c.(1309-1311)CTC>ATC	p.L437I	CTNND2_uc010itt.2_Missense_Mutation_p.L346I|CTNND2_uc011cmy.1_Missense_Mutation_p.L100I|CTNND2_uc011cmz.1_Missense_Mutation_p.L4I|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.L4I	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	437	ARM 1.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CTCTGGCTGAGACTCCTCATA	0.627													6	66					4.096e-09	4.91067e-09	1	0	T	11364871	T	T	11364871	3	4	57	1	0	0	0	0	1	0	0	0	4037	942	33	2	2428	2	CTNND2	5	11364871	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08		11364871	169550389	48	11257											
ADAMTS12	81792	broad.mit.edu	37	chr5	33576465	33576465	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagtagtgggcctttggctGgggagcagtccttccattac	7	11	14	9	0	0	0	0	0	0	0	2	2	2	1	3	4	2	3	3	4	3	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:33576465G>T	uc003jia.1	-	19	3829	c.3666C>A	c.(3664-3666)CCC>CCA	p.P1222P	ADAMTS12_uc010iuq.1_Silent_p.P1137P	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1222	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GCCTTTGGCTGGGGAGCAGTC	0.557										HNSCC(64;0.19)			43	140					1.68508e-10	2.03146e-10	1	0	T	33576465	T	T	33576465	2	4	57	1	0	0	0	0	0	0	0	1	257	1335	47	4		4	ADAMTS12	5	33576465	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	22211594	33576465	147338795	49	11258											
LIFR	3977	broad.mit.edu	37	chr5	38510706	38510706	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatcaaggggcagtttgtaTggccaatcagtgctgataac	11	10	13	7	0	2	1	2	1	0	0	2	2	2	2	1	4	2	4	1	4	4	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:38510706T>C	uc010ive.1	-	7	1183	c.851A>G	c.(850-852)CAT>CGT	p.H284R	LIFR_uc003jli.2_Missense_Mutation_p.H284R	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	284	Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					GCAGTTTGTATGGCCAATCAG	0.368			T	PLAG1	salivary adenoma								6	117					0	0	0	0	C	38510706	C	C	38510706	3	2	57	1	0	0	0	0	1	0	0	0	8821	1464	51	5	2498	5	LIFR	5	38510706	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	4934241	38510706	142404554	50	11259											
ZNF366	167465	broad.mit.edu	37	chr5	71756160	71756160	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagttgtactggatggggccCcggtgcgtggtgaggtgtct	4	11	18	8	2	1	1	0	1	1	0	1	2	1	2	2	6	2	2	2	6	1	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:71756160C>T	uc003kce.1	-	2	1350	c.1164G>A	c.(1162-1164)CGG>CGA	p.R388R		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GGATGGGGCCCCGGTGCGTGG	0.612													8	57					0	0	0	0	T	71756160	T	T	71756160	2	4	57	1	0	0	0	0	0	0	0	1	17937	610	22	4		4	ZNF366	5	71756160	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	33245454	71756160	109159100	51	11260											
PAM	5066	broad.mit.edu	37	chr5	102363940	102363940	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagagtactgggaagatttaGaggtatgcctatgacctttt	12	13	11	5	0	0	4	0	1	0	3	0	5	0	5	2	2	2	2	2	2	6	7			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:102363940G>C	uc003knw.2	+	24	3114	c.2741G>C	c.(2740-2742)AGA>ACA	p.R914T	PAM_uc003kns.2_Missense_Mutation_p.R807T|PAM_uc003knt.2_Missense_Mutation_p.R915T|PAM_uc003knu.2_Missense_Mutation_p.R846T|PAM_uc003knv.2_Intron|PAM_uc011cuz.1_Missense_Mutation_p.R816T|PAM_uc003knz.2_Intron	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	914	Cytoplasmic (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	GGAAGATTTAGAGGTATGCCT	0.373													22	146					0	0	0	0	C	102363940	C	C	102363940	3	2	57	1	0	0	0	0	1	0	0	0	11466	942	33	2	2838	2	PAM	5	102363940	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	30607780	102363940	78551320	52	11261											
MAN2A1	4124	broad.mit.edu	37	chr5	109153015	109153015	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttagaacaagaccgaatctCgttggtctcagtctatgtga	11	13	9	8	2	3	3	1	1	3	2	5	4	3	3	1	1	1	1	1	1	5	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:109153015C>T	uc003kou.1	+	13	2948	c.1985C>T	c.(1984-1986)TCG>TTG	p.S662L		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	662	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		GACCGAATCTCGTTGGTCTCA	0.403													15	183					0	0	0	0	T	109153015	T	T	109153015	3	4	57	1	0	0	0	0	1	0	0	0	9267	893	31	1	2035	1	MAN2A1	5	109153015	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	6789075	109153015	71762245	53	11262											
SHROOM1	134549	broad.mit.edu	37	chr5	132158993	132158993	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggccagggcgcggcgcacGcgcgccaggcgactgcccag	5	1	18	17	8	0	0	0	0	0	0	0	1	0	0	3	4	1	1	3	4	0	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:132158993G>A	uc003kxx.2	-	9	2980	c.2175C>T	c.(2173-2175)CGC>CGT	p.R725R	SHROOM1_uc003kxy.1_Silent_p.R725R	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	725	ASD2.				actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CGCGGCGCACGCGCGCCAGGC	0.692													6	70					0	0	0	0	A	132158993	A	A	132158993	2	1	57	1	0	0	0	0	0	0	0	1	14358	1074	38	1		1	SHROOM1	5	132158993	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	23005978	132158993	48756267	54	11263											
PCDHGA1	56114	broad.mit.edu	37	chr5	140710445	140710445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggcagatggcggagtccGcatcgtctccagaggtagga	8	7	16	10	3	1	2	0	0	1	2	4	4	2	4	2	5	0	4	2	5	1	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:140710445G>A	uc003lji.1	+	1	194	c.194G>A	c.(193-195)CGC>CAC	p.R65H	PCDHGA1_uc011dan.1_Missense_Mutation_p.R65H	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	65	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGGAGTCCGCATCGTCTCC	0.592													5	223					0	0	0	0	A	140710445	A	A	140710445	3	1	57	1	0	0	0	0	1	0	0	0	11604	1087	38	1	196	1	PCDHGA1	5	140710445	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	8551452	140710445	40204815	55	11264											
PCDHGB5	56101	broad.mit.edu	37	chr5	140779873	140779873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagctgcttccaacctggtCtctgtgtcaagtctggacct	6	12	11	12	0	3	0	1	0	2	0	5	2	4	2	3	3	3	2	3	3	2	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:140779873C>T	uc003lkf.1	+	1	2179	c.2179C>T	c.(2179-2181)CTC>TTC	p.L727F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.L727F|PCDHGA9_uc011dax.1_5'Flank|PCDHGA9_uc003lkh.1_5'Flank	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	727	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAACCTGGTCTCTGTGTCAA	0.567													35	374					0	0	0	0	T	140779873	T	T	140779873	3	4	57	1	0	0	0	0	1	0	0	0	11620	913	32	2	2181	2	PCDHGB5	5	140779873	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	69428	140779873	40135387	56	11265											
UBLCP1	134510	broad.mit.edu	37	chr5	158710239	158710239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gataaggccttttatgaaagCgcacctaaatcgtgataaag	15	10	9	7	2	0	2	0	2	0	0	1	3	0	2	2	1	1	1	2	1	7	5			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:158710239C>T	uc003lxq.2	+	10	1147	c.821C>T	c.(820-822)GCG>GTG	p.A274V		NM_145049	NP_659486	Q8WVY7	UBCP1_HUMAN	ubiquitin-like domain containing CTD phosphatase	274	FCP1 homology.					nucleus	phosphoprotein phosphatase activity			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTTATGAAAGCGCACCTAAAT	0.299													16	120					0	0	0	0	T	158710239	T	T	158710239	3	4	57	1	0	0	0	0	1	0	0	0	16959	768	27	1	855	1	UBLCP1	5	158710239	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	17930366	158710239	22205021	57	11266											
GABRA6	2559	broad.mit.edu	37	chr5	161116008	161116008	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggactgatgagaggttgaaGtttggggggccaactgagat	10	10	17	4	0	0	4	0	4	0	2	0	7	0	5	1	5	1	2	1	5	2	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:161116008G>A	uc003lyu.2	+	4	617	c.279G>A	c.(277-279)AAG>AAA	p.K93K	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	93	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGAGGTTGAAGTTTGGGGGGC	0.408										TCGA Ovarian(5;0.080)			15	190					0	0	0	0	A	161116008	A	A	161116008	2	1	57	1	0	0	0	0	0	0	0	1	6199	1020	36	4		4	GABRA6	5	161116008	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	2405769	161116008	19799252	58	11267											
ZNF354B	117608	broad.mit.edu	37	chr5	178310010	178310010	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctaaagaaaaaactccatCaaaatgtgaaatacaaagaa	23	7	5	6	0	1	3	1	1	0	2	2	3	2	3	1	0	3	1	1	0	11	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr5:178310010C>T	uc003mjl.2	+	5	783	c.557C>T	c.(556-558)TCA>TTA	p.S186L	ZNF354B_uc003mjm.2_Missense_Mutation_p.S186L	NM_058230	NP_478137	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAAACTCCATCAAAATGTGAA	0.308													11	87					0	0	0	0	T	178310010	T	T	178310010	3	4	57	1	0	0	0	0	1	0	0	0	17932	838	29	2	571	2	ZNF354B	5	178310010	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	17194002	178310010	2605250	59	11268											
HIST1H2BF	8343	broad.mit.edu	37	chr6	26199981	26199983	+	In_Frame_Del	DEL	CTT	-	-																															gccatgggcatcatgaactcCttcgtcaacgatatcttcga																										TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:26199981_26199983delCTT	uc003ngx.2	+	1	195_197	c.195_197delCTT	c.(193-198)TCCTTC>TCC	p.F66del	HIST1H3D_uc003ngv.2_5'Flank|HIST1H2AD_uc003ngw.2_5'Flank	NM_003522	NP_003513	P62807	H2B1C_HUMAN	histone cluster 1, H2bf	66					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0		all_hematologic(11;0.196)				TCATGAACTCCTTCGTCAACGAT	0.581													---	---	---								-	26199983	-	-	26199981	7	5	57	1	0	1	0	1	0	0	0	0	7184	668	24	0	197	0	HIST1H2BF	6	26199981	In_Frame_Del	DEL	CTT	TCGA-CN-5359-01A-01D-1434-08		26199981	144915086	60	11269											
HIST1H3G	8355	broad.mit.edu	37	chr6	26271590	26271590	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgccaccggtggacttgcgtGcagtctgcttggtgcgggcc	3	10	16	12	3	1	0	0	0	1	0	1	1	1	1	3	4	5	2	3	4	0	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:26271590G>A	uc003nhi.2	-	1	23	c.23C>T	c.(22-24)GCA>GTA	p.A8V	uc003nhj.2_5'Flank|HIST1H2BI_uc003nhk.2_5'Flank	NM_003534	NP_003525	P68431	H31_HUMAN	H3 histone family, member H	8					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						GGACTTGCGTGCAGTCTGCTT	0.567													5	66					0	0	0	0	A	26271590	A	A	26271590	3	1	57	1	0	0	0	0	1	0	0	0	7200	1319	46	4	391	4	HIST1H3G	6	26271590	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	71609	26271590	144843477	61	11270											
KIFC1	3833	broad.mit.edu	37	chr6	33371721	33371721	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcacaacactggaggggCatttagccaaggtacaggcc	12	5	13	11	1	0	0	0	0	0	0	0	1	0	1	2	5	4	3	2	5	4	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:33371721C>T	uc003oef.3	+	6	1021	c.571C>T	c.(571-573)CAT>TAT	p.H191Y	KIFC1_uc011drf.1_Missense_Mutation_p.H183Y	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	191	Potential.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						ACTGGAGGGGCATTTAGCCAA	0.597													43	170					0	0	0	0	T	33371721	T	T	33371721	3	4	57	1	0	0	0	0	1	0	0	0	8351	710	25	4	593	4	KIFC1	6	33371721	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	7100131	33371721	137743346	62	11271											
SLC25A27	9481	broad.mit.edu	37	chr6	46644143	46644143	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccttggtcaatggtgttctgGcttacttatgaaaaaatcag	11	14	9	7	0	3	1	2	1	1	0	3	1	3	1	1	3	1	2	1	3	6	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:46644143G>A	uc003oyh.2	+	9	1175	c.924G>A	c.(922-924)TGG>TGA	p.W308*	SLC25A27_uc011dwb.1_Intron|SLC25A27_uc003oyg.2_Intron|SLC25A27_uc011dwc.1_Nonsense_Mutation_p.W222*|SLC25A27_uc003oyi.2_Nonsense_Mutation_p.W238*	NM_004277	NP_004268	O95847	UCP4_HUMAN	solute carrier family 25, member 27	308	Helical; Name=6; (Potential).|Solcar 3.				generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane					0			Lung(136;0.192)			TGGTGTTCTGGCTTACTTATG	0.328													14	96					0	0	0	0	A	46644143	A	A	46644143	4	1	57	1	0	0	0	0	0	1	0	0	14554	1212	42	4	958	4	SLC25A27	6	46644143	Nonsense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	13272422	46644143	124470924	63	11272											
BAG2	9532	broad.mit.edu	37	chr6	57048922	57048922	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgacaaggccatcaagctAttagagcattctaaaggagc	14	9	9	9	0	3	2	1	1	2	1	3	3	3	3	1	2	3	2	1	2	6	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:57048922A>G	uc003pdr.2	+	3	962	c.570A>G	c.(568-570)CTA>CTG	p.L190L	BAG2_uc011dxo.1_Silent_p.L157L	NM_004282	NP_004273	O95816	BAG2_HUMAN	BCL2-associated athanogene 2	190					apoptosis|protein folding		protein binding				0	Lung NSC(77;0.126)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CCATCAAGCTATTAGAGCATT	0.363													12	61					0	0	0	0	G	57048922	G	G	57048922	2	3	57	1	0	0	0	0	0	0	0	1	1289	436	16	5		5	BAG2	6	57048922	Silent	SNP	A	TCGA-CN-5359-01A-01D-1434-08	10404779	57048922	114066145	64	11273											
MOXD1	26002	broad.mit.edu	37	chr6	132649650	132649650	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgtggccggactccagaacGctgtcgttaaagttgttgct	7	12	12	10	4	0	1	0	0	0	1	3	2	1	2	2	2	2	5	2	2	3	3	rs147693794	byFrequency	TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:132649650G>A	uc003qdf.2	-	5	846	c.747C>T	c.(745-747)AGC>AGT	p.S249S	MOXD1_uc003qde.2_Silent_p.S181S	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	249	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		ACTCCAGAACGCTGTCGTTAA	0.517													10	101					0	0	0	0	A	132649650	A	A	132649650	2	1	57	1	0	0	0	0	0	0	0	1	9773	1078	38	1		1	MOXD1	6	132649650	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	75600728	132649650	38465417	65	11274											
ECT2L	345930	broad.mit.edu	37	chr6	139134477	139134477	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacaagtcattaaatagacaGgtaagttacatactttaaaa	20	11	5	5	0	1	1	1	0	0	1	1	1	1	1	0	1	3	2	0	1	10	7			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:139134477G>T	uc003qif.1	+	1	169	c.66G>T	c.(64-66)CAG>CAT	p.Q22H	ECT2L_uc011edq.1_5'Flank	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	22					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TAAATAGACAGGTAAGTTACA	0.378													9	93					4.68919e-08	5.5604e-08	1	0	T	139134477	T	T	139134477	3	4	57	1	0	0	0	0	1	0	0	0	4924	1014	35	4	68	4	ECT2L	6	139134477	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	6484827	139134477	31980590	66	11275											
PLEKHG1	57480	broad.mit.edu	37	chr6	151089868	151089868	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catacaggatatctaccactTcaataggtaagttaatattc	15	13	5	8	0	2	0	1	0	1	0	3	1	2	1	1	2	2	2	1	2	8	9			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:151089868T>G	uc003qny.1	+	4	818	c.506T>G	c.(505-507)TTC>TGC	p.F169C	PLEKHG1_uc011eel.1_Missense_Mutation_p.F209C|PLEKHG1_uc011eem.1_Missense_Mutation_p.F228C|PLEKHG1_uc003qnz.2_Missense_Mutation_p.F169C	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	169	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		ATCTACCACTTCAATAGGTAA	0.393													7	46					0	0	0	0	G	151089868	G	G	151089868	3	3	57	1	0	0	0	0	1	0	0	0	12123	1783	62	5	512	5	PLEKHG1	6	151089868	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	11955391	151089868	20025199	67	11276											
PLG	5340	broad.mit.edu	37	chr6	161139390	161139390	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaacaggtgaaaactatcgCgggaatgtggctgttaccgt	11	9	14	7	3	0	1	0	1	0	0	1	3	0	3	1	4	3	2	1	4	6	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr6:161139390C>T	uc003qtm.3	+	8	915	c.852C>T	c.(850-852)CGC>CGT	p.R284R		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	284	Kringle 3.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AAAACTATCGCGGGAATGTGG	0.493													16	159					0	0	0	0	T	161139390	T	T	161139390	2	4	57	1	0	0	0	0	0	0	0	1	12141	755	27	1		1	PLG	6	161139390	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	10049522	161139390	9975677	68	11277											
IKZF1	10320	broad.mit.edu	37	chr7	50468217	50468217	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatccacatgggctgccaCggcttccgtgatccttttga	7	11	9	14	2	0	2	0	2	0	0	3	2	3	2	5	2	1	2	5	2	0	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:50468217C>T	uc003tow.3	+	9	1620	c.1452C>T	c.(1450-1452)CAC>CAT	p.H484H	IKZF1_uc003tox.3_Silent_p.H442H|IKZF1_uc003toy.3_Silent_p.H442H|IKZF1_uc011kck.1_Silent_p.H397H|IKZF1_uc003toz.3_Silent_p.H454H|IKZF1_uc010kyx.2_Silent_p.H224H|IKZF1_uc003tpa.3_Silent_p.H226H	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	484	C2H2-type 5.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				TGGGCTGCCACGGCTTCCGTG	0.587			D		ALL								7	26					0	0	0	0	T	50468217	T	T	50468217	2	4	57	1	0	0	0	0	0	0	0	1	7653	535	19	1		1	IKZF1	7	50468217	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08		50468217	108670446	69	11278											
FIGNL1	63979	broad.mit.edu	37	chr7	50514478	50514478	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaagtcttgggtccggtctcGatcatgagctgagttaggta	8	12	14	7	2	3	2	1	2	2	0	5	4	4	2	1	3	1	3	1	3	3	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:50514478G>C	uc003tpc.2	-	4	885	c.508C>G	c.(508-510)CGA>GGA	p.R170G	FIGNL1_uc003tpb.2_Missense_Mutation_p.R59G|FIGNL1_uc003tpd.2_Missense_Mutation_p.R170G|FIGNL1_uc003tpe.2_Missense_Mutation_p.R170G|FIGNL1_uc010kyy.2_Missense_Mutation_p.R170G	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	170					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				GTCCGGTCTCGATCATGAGCT	0.458													35	237					0	0	0	0	C	50514478	C	C	50514478	3	2	57	1	0	0	0	0	1	0	0	0	5924	1066	37	3	1520	3	FIGNL1	7	50514478	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	46261	50514478	108624185	70	11279											
AKAP9	10142	broad.mit.edu	37	chr7	91730273	91730273	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gactctccagaaatctttgaAaagggcagaggctgaagtat	14	9	11	7	0	2	4	0	2	2	2	3	5	2	4	1	2	0	3	1	2	5	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:91730273A>C	uc003ulg.2	+	45	11225	c.11000A>C	c.(10999-11001)AAA>ACA	p.K3667T	AKAP9_uc003ulf.2_Missense_Mutation_p.K3659T|AKAP9_uc003uli.2_Missense_Mutation_p.K3290T|AKAP9_uc003ulj.2_Missense_Mutation_p.K1437T|AKAP9_uc003ull.2_Missense_Mutation_p.K563T	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3671	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAATCTTTGAAAAGGGCAGAG	0.388			T	BRAF	papillary thyroid								18	98					0	0	0	0	C	91730273	C	C	91730273	3	2	57	1	0	0	0	0	1	0	0	0	459	14	1	5	11178	5	AKAP9	7	91730273	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	41215795	91730273	67408390	71	11280											
COL1A2	1278	broad.mit.edu	37	chr7	94038715	94038715	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggtcttccaggcctctccGgccccgttggacctcctgta	3	11	11	16	2	2	0	0	0	2	0	5	1	4	1	7	4	0	2	7	4	1	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:94038715G>A	uc003ung.1	+	17	1345	c.874G>A	c.(874-876)GGC>AGC	p.G292S	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	292					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AGGCCTCTCCGGCCCCGTTGG	0.498										HNSCC(75;0.22)			7	103					0	0	0	0	A	94038715	A	A	94038715	3	1	57	1	0	0	0	0	1	0	0	0	3693	1116	39	1	940	1	COL1A2	7	94038715	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	2308442	94038715	65099948	72	11281											
SMURF1	57154	broad.mit.edu	37	chr7	98655145	98655145	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttatggttccacacgctaAtggttatcgaatccgttttc	8	16	7	10	3	1	0	0	0	1	0	5	1	3	0	2	2	0	4	2	2	4	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:98655145A>C	uc003upu.1	-	4	553	c.233T>G	c.(232-234)ATT>AGT	p.I78S	SMURF1_uc003upv.1_Missense_Mutation_p.I78S|SMURF1_uc003upt.2_Missense_Mutation_p.I78S	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	78	C2.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			CCACACGCTAATGGTTATCGA	0.363													8	57					0	0	0	0	C	98655145	C	C	98655145	3	2	57	1	0	0	0	0	1	0	0	0	14883	101	4	5	2104	5	SMURF1	7	98655145	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	4616430	98655145	60483518	73	11282											
SPDYE6	729597	broad.mit.edu	37	chr7	101989051	101989052	+	Frame_Shift_Ins	INS	-	T	T																															tgcgagagcggttcttcctaINStacaggaagtggaagatgtt																										TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:101989051_101989052insT	uc011kkp.1	-	6	1242_1243	c.821_822insA	c.(820-822)TATfs	p.Y274fs	SPDYE6_uc003uzb.2_Frame_Shift_Ins_p.Y130fs	NM_001146210	NP_001139682	P0CI01	SPDE6_HUMAN	speedy homolog E6	274											0						GGTTCTTCCTATACAGGAAGTG	0.545													---	---	---								T	101989052	T	T	101989051	7	5	57	1	0	1	1	0	0	0	0	0	15099	456	16	0	394	0	SPDYE6	7	101989051	Frame_Shift_Ins	INS	-	TCGA-CN-5359-01A-01D-1434-08	3333906	101989051	57149612	74	11283											
TFEC	22797	broad.mit.edu	37	chr7	115624314	115624314	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tataaccagccattagacatAcatgccattgtgcattgtca	13	12	6	10	0	1	1	1	0	0	1	1	1	1	1	3	0	5	1	3	0	4	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:115624314A>G	uc003vhj.1	-	2	364	c.180_splice	c.e2+1	p.H60_splice	TFEC_uc003vhk.1_Splice_Site_p.H60_splice|TFEC_uc003vhl.3_Splice_Site_p.H60_splice|TFEC_uc011kmw.1_Splice_Site_p.H150_splice	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			CATTAGACATACATGCCATTG	0.363													18	229					0	0	0	0	G	115624314	G	G	115624314	5	3	57	1	0	0	0	0	0	0	1	0	15868	405	14	5	889	5	TFEC	7	115624314	Splice_Site	SNP	A	TCGA-CN-5359-01A-01D-1434-08	13635263	115624314	43514349	75	11284											
TNPO3	23534	broad.mit.edu	37	chr7	128655071	128655071	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actagagtagaaggccaaatCttctataatttctgtgcgcc	12	12	8	9	1	3	2	0	0	3	2	3	2	3	2	2	1	1	1	2	1	6	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr7:128655071C>A	uc003vol.1	-	4	888	c.514G>T	c.(514-516)GAT>TAT	p.D172Y	TNPO3_uc003vom.1_Missense_Mutation_p.D106Y|TNPO3_uc010lly.1_Missense_Mutation_p.D172Y|TNPO3_uc010llz.1_Missense_Mutation_p.D172Y	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	172					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						AAGGCCAAATCTTCTATAATT	0.393													12	118					7.93312e-07	9.15685e-07	1	0	A	128655071	A	A	128655071	3	1	57	1	0	0	0	0	1	0	0	0	16403	913	32	2	2333	2	TNPO3	7	128655071	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	13030757	128655071	30483592	76	11285											
SNTG1	54212	broad.mit.edu	37	chr8	51449368	51449368	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccggcacagatttgagtcGgtgagtccgtgtttaggagt	7	11	15	8	3	0	3	0	2	0	1	2	4	1	4	2	3	0	2	2	3	1	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr8:51449368G>T	uc010lxy.1	+	12	1051	c.680G>T	c.(679-681)CGG>CTG	p.R227L	SNTG1_uc003xqs.1_Missense_Mutation_p.R227L|SNTG1_uc010lxz.1_Missense_Mutation_p.R227L|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	227					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GATTTGAGTCGGTGAGTCCGT	0.438													44	279					3.86361e-14	4.79087e-14	1	0	T	51449368	T	T	51449368	3	4	57	1	0	0	0	0	1	0	0	0	14938	1130	39	3	714	3	SNTG1	8	51449368	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08		51449368	94914654	77	11286											
EYA1	2138	broad.mit.edu	37	chr8	72184055	72184055	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggccccgtccacgtgattTcccatctgaacctcgacgca	7	9	8	17	5	1	2	0	2	1	0	5	3	3	2	5	1	1	1	5	1	1	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr8:72184055T>G	uc003xys.3	-	9	1191	c.904A>C	c.(904-906)AAA>CAA	p.K302Q	EYA1_uc003xyr.3_Missense_Mutation_p.K297Q|EYA1_uc003xyt.3_Missense_Mutation_p.K269Q|EYA1_uc010lzf.2_Missense_Mutation_p.K229Q|EYA1_uc003xyu.2_Missense_Mutation_p.K302Q|EYA1_uc011lfe.1_Missense_Mutation_p.K296Q|EYA1_uc003xyv.2_Missense_Mutation_p.K180Q	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	302					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CCACGTGATTTCCCATCTGAA	0.468													33	419					0	0	0	0	G	72184055	G	G	72184055	3	3	57	1	0	0	0	0	1	0	0	0	5353	1792	62	5	910	5	EYA1	8	72184055	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	20734687	72184055	74179967	78	11287											
MTERFD1	51001	broad.mit.edu	37	chr8	97251890	97251890	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaagtgtctttctttgacCttaaacagccttgtattaaa	13	15	5	8	0	2	1	0	1	2	0	2	1	2	1	2	0	3	1	2	0	7	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr8:97251890C>G	uc003yhs.1	-	8	1161	c.1083G>C	c.(1081-1083)AAG>AAC	p.K361N	MTERFD1_uc003yhr.1_Missense_Mutation_p.K240N|MTERFD1_uc010mbd.1_3'UTR	NM_015942	NP_057026	Q96E29	MTER1_HUMAN	MTERF domain containing 1 precursor	361					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			ovary(1)	1	Breast(36;5.16e-05)					TTTCTTTGACCTTAAACAGCC	0.323													15	91					0	0	0	0	G	97251890	G	G	97251890	3	3	57	1	0	0	0	0	1	0	0	0	9972	680	24	4	174	4	MTERFD1	8	97251890	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	25067835	97251890	49112132	79	11288											
PKHD1L1	93035	broad.mit.edu	37	chr8	110445377	110445377	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctaaccatagtgggttctgGattttctcctagttcagctg	7	16	9	9	0	4	0	1	0	3	0	5	1	4	1	2	2	2	3	2	2	3	7			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr8:110445377G>T	uc003yne.2	+	28	3376	c.3272G>T	c.(3271-3273)GGA>GTA	p.G1091V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1091	Extracellular (Potential).|IPT/TIG 4.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTGGGTTCTGGATTTTCTCCT	0.333										HNSCC(38;0.096)			35	497					9.62906e-15	1.21483e-14	1	0	T	110445377	T	T	110445377	3	4	57	1	0	0	0	0	1	0	0	0	12027	1174	41	2	3382	2	PKHD1L1	8	110445377	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	13193487	110445377	35918645	80	11289											
EPPK1	83481	broad.mit.edu	37	chr8	144944117	144944117	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagtctcatccctggggCactcctccaggagctgggca	8	7	12	14	0	1	1	1	0	1	1	5	2	4	2	3	4	1	3	3	4	1	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr8:144944117C>A	uc003zaa.1	-	1	3318	c.3305G>T	c.(3304-3306)TGC>TTC	p.C1102F		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1102						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ATCCCTGGGGCACTCCTCCAG	0.657													12	19					2.27111e-07	2.66395e-07	1	0	A	144944117	A	A	144944117	3	1	57	1	0	0	0	0	1	0	0	0	5214	710	25	4	3961	4	EPPK1	8	144944117	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	34498740	144944117	1419905	81	11290											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	15					0	0	0	0	A	21971120	A	A	21971120	4	1	57	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08		21971120	119242311	82	11291											
PTCH1	5727	broad.mit.edu	37	chr9	98238315	98238315	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccttcatcaccagaagctcaCctggagggagaacgcccgca	11	5	10	15	2	3	2	3	0	0	2	3	4	3	3	4	2	2	2	4	2	2	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr9:98238315C>A	uc004avk.3	-	12	1916	c.1728_splice	c.e12+1	p.Q576_splice	PTCH1_uc010mro.2_Splice_Site_p.Q425_splice|PTCH1_uc010mrp.2_Splice_Site_p.Q425_splice|PTCH1_uc010mrq.2_Splice_Site_p.Q425_splice|PTCH1_uc004avl.3_Splice_Site_p.Q425_splice|PTCH1_uc010mrr.2_Splice_Site_p.Q510_splice|PTCH1_uc004avm.3_Splice_Site_p.Q575_splice|PTCH1_uc010mrs.1_Splice_Site_p.Q244_splice	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L						embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CAGAAGCTCACCTGGAGGGAG	0.567									Basal_Cell_Nevus_syndrome				24	41					2.41591e-17	3.10209e-17	1	0	A	98238315	A	A	98238315	5	1	57	1	0	0	0	0	0	0	1	0	12792	521	18	4	2662	4	PTCH1	9	98238315	Splice_Site	SNP	C	TCGA-CN-5359-01A-01D-1434-08	76267195	98238315	42975116	83	11292											
ASTN2	23245	broad.mit.edu	37	chr9	119976896	119976896	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcacagatgggatgtagtgGatctcatgagtggcttctgt	9	12	14	6	0	2	2	1	1	2	1	3	4	2	4	0	3	1	3	0	3	1	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr9:119976896G>T	uc004bjs.1	-	3	857	c.756C>A	c.(754-756)ATC>ATA	p.I252I	ASTN2_uc004bjr.1_Silent_p.I252I|ASTN2_uc004bjt.1_Silent_p.I252I	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	252	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GGATGTAGTGGATCTCATGAG	0.627													34	44					1.06647e-15	1.35336e-15	1	0	T	119976896	T	T	119976896	2	4	57	1	0	0	0	0	0	0	0	1	1067	1164	41	2		2	ASTN2	9	119976896	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	21738581	119976896	21236535	84	11293											
OR1Q1	158131	broad.mit.edu	37	chr9	125377720	125377720	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccctcagccaagggcaggtGgaaaaccttttctacctgcg	9	8	10	14	1	2	0	1	0	1	0	2	1	2	1	5	3	4	1	5	3	4	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr9:125377720G>T	uc011lyy.1	+	1	704	c.704G>T	c.(703-705)TGG>TTG	p.W235L		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AAGGGCAGGTGGAAAACCTTT	0.557													48	165					1.81118e-26	2.35345e-26	1	0	T	125377720	T	T	125377720	3	4	57	1	0	0	0	0	1	0	0	0	11025	1357	47	4	706	4	OR1Q1	9	125377720	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	5400824	125377720	15835711	85	11294											
ADARB2	105	broad.mit.edu	37	chr10	1405308	1405308	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctgcagtgcggcctgcgcgGcctgaccccgggccagcttc	3	6	14	18	4	0	1	0	1	0	0	1	1	0	1	6	3	4	2	6	3	0	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:1405308G>A	uc009xhq.2	-	3	1366	c.992C>T	c.(991-993)GCC>GTC	p.A331V		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	331	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GGCCTGCGCGGCCTGACCCCG	0.751													3	21					0	0	0	0	A	1405308	A	A	1405308	3	1	57	1	0	0	0	0	1	0	0	0	283	1203	42	4	1259	4	ADARB2	10	1405308	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08		1405308	134129439	86	11295											
ZNF33A	7581	broad.mit.edu	37	chr10	38344239	38344239	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgggaaagcctttagccAtaagtcagccctcacattac	12	10	8	11	0	2	0	2	0	0	0	2	1	2	1	3	1	4	0	3	1	4	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:38344239A>T	uc001izh.2	+	5	1362	c.1184A>T	c.(1183-1185)CAT>CTT	p.H395L	ZNF33A_uc001izg.2_Missense_Mutation_p.H396L|ZNF33A_uc010qev.1_Missense_Mutation_p.H402L|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	395	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						GCCTTTAGCCATAAGTCAGCC	0.423													11	138					0	0	0	0	T	38344239	T	T	38344239	3	4	57	1	0	0	0	0	1	0	0	0	17921	217	8	5	1201	5	ZNF33A	10	38344239	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	36938931	38344239	97190508	87	11296											
ZNF239	8187	broad.mit.edu	37	chr10	44053142	44053142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcaccatttaacaatggcGaggccagttcttgtccatca	10	11	7	13	1	3	0	2	0	1	0	4	1	4	0	4	2	1	1	4	2	2	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:44053142G>A	uc001jaw.3	-	2	1039	c.386C>T	c.(385-387)TCG>TTG	p.S129L	ZNF239_uc001jax.3_Missense_Mutation_p.S129L|ZNF239_uc009xmj.2_Missense_Mutation_p.S129L|ZNF239_uc009xmk.2_Missense_Mutation_p.S129L	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						TAACAATGGCGAGGCCAGTTC	0.413													9	239					0	0	0	0	A	44053142	A	A	44053142	3	1	57	1	0	0	0	0	1	0	0	0	17858	1059	37	1	994	1	ZNF239	10	44053142	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	5708903	44053142	91481605	88	11297											
RGR	5995	broad.mit.edu	37	chr10	86012692	86012692	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccttctgggcagctctgccCcttctgggttggggtcacta	3	12	13	13	0	4	0	1	0	3	0	4	0	4	0	3	4	2	3	3	4	1	4	rs141356847		TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:86012692C>A	uc001kdc.1	+	4	476	c.438C>A	c.(436-438)CCC>CCA	p.P146P	RGR_uc001kdd.1_Silent_p.P150P|RGR_uc001kde.1_Silent_p.P146P	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	146	Helical; Name=4; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						CAGCTCTGCCCCTTCTGGGTT	0.607													9	112					5.16669e-11	6.26352e-11	1	0	A	86012692	A	A	86012692	2	1	57	1	0	0	0	0	0	0	0	1	13356	610	22	4		4	RGR	10	86012692	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	41959550	86012692	49522055	89	11298											
GRID1	2894	broad.mit.edu	37	chr10	87614257	87614257	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagcctgaggcttaccttgCgcatgtctttgccaaaagtc	8	11	11	11	1	1	1	0	1	1	0	2	2	1	2	3	2	4	2	3	2	3	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:87614257C>T	uc001kdl.1	-	8	1330	c.1229G>A	c.(1228-1230)CGC>CAC	p.R410H	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	410	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	GCTTACCTTGCGCATGTCTTT	0.512										Multiple Myeloma(13;0.14)			9	65					0	0	0	0	T	87614257	T	T	87614257	3	4	57	1	0	0	0	0	1	0	0	0	6810	768	27	1	1836	1	GRID1	10	87614257	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	1601565	87614257	47920490	90	11299											
C10orf96	374355	broad.mit.edu	37	chr10	118100359	118100359	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaatatgcttcttcaaacCtttgtaagtttccagccacc	11	13	6	11	0	2	0	1	0	1	0	3	1	3	1	4	1	3	3	4	1	4	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr10:118100359C>A	uc001lck.2	+	4	530	c.279C>A	c.(277-279)ACC>ACA	p.T93T		NM_198515	NP_940917	P0C7W6	CJ096_HUMAN	hypothetical protein LOC374355	93										ovary(2)	2		Lung NSC(174;0.204)|all_lung(145;0.248)		all cancers(201;0.014)		TTCTTCAAACCTTTGTAAGTT	0.284													11	118					0.00010058	0.000111356	1	0	A	118100359	A	A	118100359	2	1	57	1	0	0	0	0	0	0	0	1	1633	668	24	4		4	C10orf96	10	118100359	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	30486102	118100359	17434388	91	11300											
OR52E2	119678	broad.mit.edu	37	chr11	5080058	5080058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggatatagcggggcacatttCggccaaagcgatgagtcata	12	8	13	8	3	1	1	1	1	0	0	2	3	1	2	1	4	2	1	1	4	4	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:5080058C>T	uc010qyw.1	-	1	800	c.800G>A	c.(799-801)CGA>CAA	p.R267Q		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGGCACATTTCGGCCAAAGCG	0.478													4	101					0	0	0	0	T	5080058	T	T	5080058	3	4	57	1	0	0	0	0	1	0	0	0	11169	884	31	1	180	1	OR52E2	11	5080058	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08		5080058	129926458	92	11301											
OR52A4	390053	broad.mit.edu	37	chr11	5142432	5142432	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gataacagatcgctacacagCggtccagagccatggctagc	12	6	11	12	2	0	2	0	0	0	2	2	3	1	2	2	2	5	2	2	2	3	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:5142432C>T	uc001lzz.1	-	1	377	c.377G>A	c.(376-378)CGC>CAC	p.R126H	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CGCTACACAGCGGTCCAGAGC	0.473													5	50					0	0	0	0	T	5142432	T	T	5142432	3	4	57	1	0	0	0	0	1	0	0	0	11163	768	27	1	541	1	OR52A4	11	5142432	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	62374	5142432	129864084	93	11302											
OR52B2	255725	broad.mit.edu	37	chr11	6191298	6191298	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttatgtgcttgaagccaaaAgatggctagggccttgggca	10	10	14	7	0	0	2	0	1	0	1	0	2	0	2	2	3	2	4	2	3	5	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:6191298A>C	uc010qzy.1	-	1	259	c.259T>G	c.(259-261)TTT>GTT	p.F87V		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGAAGCCAAAAGATGGCTAGG	0.493													16	160					0	0	0	0	C	6191298	C	C	6191298	3	2	57	1	0	0	0	0	1	0	0	0	11165	72	3	5	715	5	OR52B2	11	6191298	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	1048866	6191298	128815218	94	11303											
SERGEF	26297	broad.mit.edu	37	chr11	17981067	17981067	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgaaggcatgctgttcggtgGtcttgaacaggggagaaatg	10	9	16	6	2	1	2	0	1	1	1	2	4	1	2	0	5	2	3	0	5	3	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:17981067G>A	uc001mnm.2	-	9	1041	c.961C>T	c.(961-963)CCA>TCA	p.P321S	SERGEF_uc009yhd.2_RNA|SERGEF_uc001mnn.2_Intron|SERGEF_uc010rcz.1_Intron|SERGEF_uc001mno.1_Missense_Mutation_p.P207S	NM_012139	NP_036271	Q9UGK8	SRGEF_HUMAN	deafness locus associated putative guanine	321	RCC1 6.				negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1						CTGTTCGGTGGTCTTGAACAG	0.468													11	76					0	0	0	0	A	17981067	A	A	17981067	3	1	57	1	0	0	0	0	1	0	0	0	14142	1261	44	4	427	4	SERGEF	11	17981067	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	11789769	17981067	117025449	95	11304											
ANO5	203859	broad.mit.edu	37	chr11	22296150	22296150	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttacgtcagacatcattccCcgtctagtttactactatgc	9	15	5	12	2	3	1	2	0	1	1	4	1	4	1	2	0	4	1	2	0	5	8			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:22296150C>A	uc001mqi.2	+	20	2588	c.2271C>A	c.(2269-2271)CCC>CCA	p.P757P	ANO5_uc001mqj.2_Silent_p.P756P	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	757	Extracellular (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						ACATCATTCCCCGTCTAGTTT	0.358													10	171					0.000978159	0.0010613	1	0	A	22296150	A	A	22296150	2	1	57	1	0	0	0	0	0	0	0	1	700	610	22	4		4	ANO5	11	22296150	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	4315083	22296150	112710366	96	11305											
PTPRJ	5795	broad.mit.edu	37	chr11	48181492	48181492	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgttctagaccaaatgtgAggagtattggccctccaagc	10	12	10	9	0	1	2	0	1	1	1	2	3	2	3	3	2	1	2	3	2	4	5			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:48181492A>T	uc001ngp.3	+	22	3804	c.3449A>T	c.(3448-3450)GAG>GTG	p.E1150V		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1150	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						ACCAAATGTGAGGAGTATTGG	0.423													16	148					0	0	0	0	T	48181492	T	T	48181492	3	4	57	1	0	0	0	0	1	0	0	0	12869	304	11	5	3544	5	PTPRJ	11	48181492	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	25885342	48181492	86825024	97	11306											
APLNR	187	broad.mit.edu	37	chr11	57003872	57003872	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcccacggtggtggacgagaCcccaaggcccacctcccagg	8	3	13	17	2	0	1	0	0	0	1	1	3	1	2	6	5	0	0	6	5	1	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:57003872C>G	uc001njo.2	-	1	1056	c.607G>C	c.(607-609)GTC>CTC	p.V203L	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	203	Helical; Name=5; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						GTGGACGAGACCCCAAGGCCC	0.592													8	69					0	0	0	0	G	57003872	G	G	57003872	3	3	57	1	0	0	0	0	1	0	0	0	777	507	18	4	539	4	APLNR	11	57003872	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	8822380	57003872	78002644	98	11307											
ZFP91	80829	broad.mit.edu	37	chr11	58384739	58384739	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatgaagaaacatgatgcaGactccttctaccagttttct	13	12	6	10	0	2	4	0	2	2	2	3	4	3	4	2	0	3	2	2	0	3	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:58384739G>A	uc001nmx.3	+	11	1441	c.1273G>A	c.(1273-1275)GAC>AAC	p.D425N	ZFP91_uc001nmy.3_Missense_Mutation_p.D424N|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	425					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				ACATGATGCAGACTCCTTCTA	0.428													11	132					0	0	0	0	A	58384739	A	A	58384739	3	1	57	1	0	0	0	0	1	0	0	0	17722	942	33	2	1315	2	ZFP91	11	58384739	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	1380867	58384739	76621777	99	11308											
MS4A6A	64231	broad.mit.edu	37	chr11	59943062	59943062	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagacagagcactcagaatgCttccaaccaggctgctatgc	12	7	9	13	0	1	3	1	0	0	3	2	3	2	3	2	1	5	4	2	1	3	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:59943062C>T	uc001nor.2	-	5	600	c.362G>A	c.(361-363)AGC>AAC	p.S121N	MS4A6A_uc001noq.2_Missense_Mutation_p.S121N|MS4A6A_uc001nos.3_Missense_Mutation_p.S149N|MS4A6A_uc009ymv.2_Missense_Mutation_p.S121N|MS4A6A_uc001not.2_Missense_Mutation_p.S121N|MS4A6A_uc010rla.1_Missense_Mutation_p.S149N|MS4A6A_uc010rlb.1_Missense_Mutation_p.S76N	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	121	Helical; (Potential).					integral to membrane	receptor activity				0						ACTCAGAATGCTTCCAACCAG	0.438													35	84					0	0	0	0	T	59943062	T	T	59943062	3	4	57	1	0	0	0	0	1	0	0	0	9917	797	28	4	423	4	MS4A6A	11	59943062	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	1558323	59943062	75063454	100	11309											
INTS5	80789	broad.mit.edu	37	chr11	62415548	62415548	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgagaagctgacaggctgaGgccacacctgggggtccatg	9	6	16	10	0	0	3	0	3	0	1	1	4	1	3	3	4	1	2	3	4	1	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:62415548G>A	uc001nud.2	-	2	2057	c.2004C>T	c.(2002-2004)GCC>GCT	p.A668A	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	668					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						GACAGGCTGAGGCCACACCTG	0.612													4	71					0	0	0	0	A	62415548	A	A	62415548	2	1	57	1	0	0	0	0	0	0	0	1	7820	987	35	4		4	INTS5	11	62415548	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	2472486	62415548	72590968	101	11310											
ARHGEF17	9828	broad.mit.edu	37	chr11	73074856	73074856	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcatgaagctccagcatGcggcctctgtgacctgcatc	9	8	10	14	1	1	2	0	2	1	0	3	2	2	2	3	1	5	4	3	1	1	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:73074856G>A	uc001otu.2	+	16	5332	c.5311G>A	c.(5311-5313)GCG>ACG	p.A1771T		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1771					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GCTCCAGCATGCGGCCTCTGT	0.582													17	85					0	0	0	0	A	73074856	A	A	73074856	3	1	57	1	0	0	0	0	1	0	0	0	900	1319	46	4	5373	4	ARHGEF17	11	73074856	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	10659308	73074856	61931660	102	11311											
NARS2	79731	broad.mit.edu	37	chr11	78176976	78176976	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaaaggcttgagtgttaaTggataattaataacgaagac	17	11	10	3	1	0	3	0	1	0	2	0	5	0	4	0	2	1	2	0	2	7	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:78176976T>C	uc001ozi.2	-	11	1486	c.1110A>G	c.(1108-1110)CCA>CCG	p.P370P	NARS2_uc010rsq.1_Silent_p.P143P	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	370					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	TGAGTGTTAATGGATAATTAA	0.428													10	120					0	0	0	0	C	78176976	C	C	78176976	2	2	57	1	0	0	0	0	0	0	0	1	10224	1451	51	5		5	NARS2	11	78176976	Silent	SNP	T	TCGA-CN-5359-01A-01D-1434-08	5102120	78176976	56829540	103	11312											
FAT3	120114	broad.mit.edu	37	chr11	92085715	92085715	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcatggaccaaagtgaataTacaggttttagatatgaatg	16	11	10	4	0	0	3	0	2	0	1	0	4	0	4	1	2	2	2	1	2	7	5			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:92085715T>C	uc001pdj.3	+	1	454	c.437T>C	c.(436-438)ATA>ACA	p.I146T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	146	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAAGTGAATATACAGGTTTTA	0.378										TCGA Ovarian(4;0.039)			6	61					0	0	0	0	C	92085715	C	C	92085715	3	2	57	1	0	0	0	0	1	0	0	0	5723	1406	49	5	439	5	FAT3	11	92085715	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	13908739	92085715	42920801	104	11313											
ARHGEF12	23365	broad.mit.edu	37	chr11	120352147	120352147	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatttcaccattcaccccCgaatttctggtccagcagcg	9	10	7	15	2	3	0	2	0	1	0	4	1	4	0	4	1	2	2	4	1	2	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:120352147C>T	uc001pxl.1	+	39	4423	c.4416C>T	c.(4414-4416)CCC>CCT	p.P1472P	ARHGEF12_uc009zau.1_Silent_p.P1369P	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1472					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CATTCACCCCCGAATTTCTGG	0.532			T	MLL	AML								6	95					0	0	0	0	T	120352147	T	T	120352147	2	4	57	1	0	0	0	0	0	0	0	1	897	639	23	1		1	ARHGEF12	11	120352147	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	28266432	120352147	14654369	105	11314											
SIAE	54414	broad.mit.edu	37	chr11	124524555	124524555	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaagccgtcacatacctgaGgtgggcttagaccactgcaa	11	8	10	12	1	2	2	2	1	0	1	2	2	2	2	3	2	3	2	3	2	4	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:124524555G>C	uc001qan.2	-	4	653	c.540C>G	c.(538-540)ACC>ACG	p.T180T		NM_170601	NP_733746	Q9HAT2	SIAE_HUMAN	sialate O-acetylesterase precursor	180						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		ACATACCTGAGGTGGGCTTAG	0.483													21	234					0	0	0	0	C	124524555	C	C	124524555	2	2	57	1	0	0	0	0	0	0	0	1	14363	987	35	4		4	SIAE	11	124524555	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	4172408	124524555	10481961	106	11315											
ACAD8	27034	broad.mit.edu	37	chr11	134131756	134131756	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggccttgtgctccatggccaAgctctttgctacagatgaat	8	12	10	11	0	1	2	0	1	1	1	2	2	2	2	3	2	4	3	3	2	3	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr11:134131756A>T	uc001qhk.2	+	9	1125	c.1064A>T	c.(1063-1065)AAG>ATG	p.K355M	ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Missense_Mutation_p.K278M|ACAD8_uc001qhl.2_Missense_Mutation_p.K228M	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	355					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		TCCATGGCCAAGCTCTTTGCT	0.582													4	54					0	0	0	0	T	134131756	T	T	134131756	3	4	57	1	0	0	0	0	1	0	0	0	110	72	3	5	1098	5	ACAD8	11	134131756	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	9607201	134131756	874760	107	11316											
SCNN1A	6337	broad.mit.edu	37	chr12	6457162	6457162	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggagagggagcagggccTggctgggacaaggacagaga	11	3	20	7	0	0	2	0	0	0	2	0	7	0	5	1	6	1	3	1	6	1	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr12:6457162T>C	uc001qnx.2	-	13	2176	c.1887A>G	c.(1885-1887)CCA>CCG	p.P629P	SCNN1A_uc001qnv.2_Silent_p.P329P|SCNN1A_uc001qnw.2_Silent_p.P688P|SCNN1A_uc010sfb.1_Silent_p.P652P	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	629	Cytoplasmic (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	gagcagggcctggctgggaca	0.219													4	14					0	0	0	0	C	6457162	C	C	6457162	2	2	57	1	0	0	0	0	0	0	0	1	13992	1567	55	5		5	SCNN1A	12	6457162	Silent	SNP	T	TCGA-CN-5359-01A-01D-1434-08		6457162	127394733	108	11317											
USP5	8078	broad.mit.edu	37	chr12	6972476	6972481	+	In_Frame_Del	DEL	GCCTTG	-	-																															tccggatgagcccaaaggtaGccttggtttctatggcaacg																										TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr12:6972476_6972481delGCCTTG	uc001qri.3	+	15	1948_1953	c.1889_1894delGCCTTG	c.(1888-1896)AGCCTTGGT>AGT	p.LG631del	USP5_uc001qrh.3_Intron	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	631_632					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						CCCAAAGGTAGCCTTGGTTTCTATGG	0.587													---	---	---								-	6972481	-	-	6972476	7	5	57	1	0	1	0	1	0	0	0	0	17149	971	34	0	1947	0	USP5	12	6972476	In_Frame_Del	DEL	GCCTTG	TCGA-CN-5359-01A-01D-1434-08	515314	6972476	126879419	109	11318											
RIMKLB	57494	broad.mit.edu	37	chr12	8926168	8926168	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccggctcacccggcgtatgTccctgctctccgtggtgtcc	2	10	12	17	4	2	0	1	0	1	0	5	0	4	0	5	3	1	3	5	3	1	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr12:8926168T>C	uc001quu.2	+	6	1200	c.949T>C	c.(949-951)TCC>CCC	p.S317P	RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_Missense_Mutation_p.S317P|RIMKLB_uc010sgl.1_Missense_Mutation_p.S317P|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	317					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CCGGCGTATGTCCCTGCTCTC	0.562													29	108					0	0	0	0	C	8926168	C	C	8926168	3	2	57	1	0	0	0	0	1	0	0	0	13431	1667	58	5	967	5	RIMKLB	12	8926168	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	1953692	8926168	124925727	110	11319											
ADAMTS20	80070	broad.mit.edu	37	chr12	43944862	43944862	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcacctcggtgtagccggcGgccagaaaggatgcatcggc	8	6	15	12	4	0	1	0	0	0	1	2	2	0	2	3	5	3	3	3	5	2	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr12:43944862G>A	uc010skx.1	-	2	303	c.303C>T	c.(301-303)GCC>GCT	p.A101A		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	101						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TGTAGCCGGCGGCCAGAAAGG	0.682													8	18					0	0	0	0	A	43944862	A	A	43944862	2	1	57	1	0	0	0	0	0	0	0	1	266	1103	39	1		1	ADAMTS20	12	43944862	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	35018694	43944862	89907033	111	11320											
CCDC64	92558	broad.mit.edu	37	chr12	120527826	120527826	+	Frame_Shift_Del	DEL	A	-	-																															tctgaacagccagttgctggAtgccattcagcagaaactga																										TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr12:120527826delA	uc001txl.1	+	8	1536	c.1511delA	c.(1510-1512)GATfs	p.D504fs	CCDC64_uc009zwv.1_RNA|CCDC64_uc010sze.1_Frame_Shift_Del_p.D175fs|CCDC64_uc010szf.1_Frame_Shift_Del_p.D201fs	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	504	Potential.				Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGTTGCTGGATGCCATTCAG	0.532													---	---	---								-	120527826	-	-	120527826	7	5	57	1	0	1	0	1	0	0	0	0	2848	333	12	0	1541	0	CCDC64	12	120527826	Frame_Shift_Del	DEL	A	TCGA-CN-5359-01A-01D-1434-08	76582964	120527826	13324069	112	11321											
ENOX1	55068	broad.mit.edu	37	chr13	43918857	43918857	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaatccaggaaagcagcaCtgtgatagcctctgaaaact	14	9	8	10	0	2	2	1	2	1	0	3	3	3	3	2	1	4	2	2	1	5	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr13:43918857C>T	uc001uza.3	-	9	1153	c.853G>A	c.(853-855)GTG>ATG	p.V285M	ENOX1_uc001uzb.3_Missense_Mutation_p.V285M|ENOX1_uc001uzc.3_Missense_Mutation_p.V285M|ENOX1_uc001uyz.3_Translation_Start_Site|ENOX1_uc010tfm.1_Missense_Mutation_p.V98M	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	285					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GAAAGCAGCACTGTGATAGCC	0.468													8	85					0	0	0	0	T	43918857	T	T	43918857	3	4	57	1	0	0	0	0	1	0	0	0	5150	565	20	4	1114	4	ENOX1	13	43918857	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08		43918857	71251021	113	11322											
KLHL1	57626	broad.mit.edu	37	chr13	70456501	70456501	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtcatacttgacccacaTcatcaatgcatggaagatgg	13	10	8	10	0	3	2	3	1	0	1	3	3	3	3	1	2	2	1	1	2	3	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr13:70456501T>A	uc001vip.2	-	5	1935	c.1141A>T	c.(1141-1143)ATG>TTG	p.M381L	KLHL1_uc010thm.1_Missense_Mutation_p.M320L	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	381					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TTGACCCACATCATCAATGCA	0.443													27	110					0	0	0	0	A	70456501	A	A	70456501	3	1	57	1	0	0	0	0	1	0	0	0	8404	1435	50	5	1133	5	KLHL1	13	70456501	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	26537644	70456501	44713377	114	11323											
DACH1	1602	broad.mit.edu	37	chr13	72204713	72204713	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttgaattcatgtccccgttTtcagagtctgctccatgttg	6	16	8	11	1	3	2	2	1	1	1	5	2	5	2	3	0	1	3	3	0	1	5			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr13:72204713T>A	uc010thn.1	-	4	1524	c.1101A>T	c.(1099-1101)GAA>GAT	p.E367D	DACH1_uc010tho.1_Missense_Mutation_p.E367D|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	367	Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TGTCCCCGTTTTCAGAGTCTG	0.333													46	473					0	0	0	0	A	72204713	A	A	72204713	3	1	57	1	0	0	0	0	1	0	0	0	4237	1838	64	5	1055	5	DACH1	13	72204713	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	1748212	72204713	42965165	115	11324											
OR4K1	79544	broad.mit.edu	37	chr14	20404174	20404174	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgagatgatgttgcttgtaGctatggcatatgacagattt	10	15	12	4	0	0	4	0	3	0	2	0	5	0	4	0	1	2	5	0	1	3	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr14:20404174G>T	uc001vwj.1	+	1	349	c.349G>T	c.(349-351)GCT>TCT	p.A117S		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GTTGCTTGTAGCTATGGCATA	0.418													16	163					0.000422831	0.000463406	1	0	T	20404174	T	T	20404174	3	4	57	1	0	0	0	0	1	0	0	0	11121	971	34	4	351	4	OR4K1	14	20404174	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08		20404174	86945366	116	11325											
SDCCAG1	9147	broad.mit.edu	37	chr14	50312960	50312960	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgttttgcactgactaatctCcgactcttcaaatgttttcg	8	17	6	10	2	3	1	1	1	2	0	5	2	3	1	1	0	1	3	1	0	2	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr14:50312960C>T	uc001wxc.2	-	4	323	c.255G>A	c.(253-255)CGG>CGA	p.R85R	SDCCAG1_uc010anj.1_Silent_p.R85R|SDCCAG1_uc010tqi.1_Silent_p.R85R|SDCCAG1_uc001wxe.2_Intron|SDCCAG1_uc010anq.1_5'UTR	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	85						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		TGACTAATCTCCGACTCTTCA	0.343													5	115					0	0	0	0	T	50312960	T	T	50312960	2	4	57	1	0	0	0	0	0	0	0	1	14022	842	30	2		2	SDCCAG1	14	50312960	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	29908786	50312960	57036580	117	11326											
EXOC5	10640	broad.mit.edu	37	chr14	57676773	57676773	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atctgtccaatcatacaattTaatgtcctagagaattgaga	15	13	6	7	0	2	2	1	1	1	2	4	4	4	2	2	0	1	0	2	0	6	5			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr14:57676773T>G	uc001xct.2	-	16	1871	c.1620A>C	c.(1618-1620)TTA>TTC	p.L540F	EXOC5_uc001xcs.2_Missense_Mutation_p.L219F|EXOC5_uc010trg.1_Missense_Mutation_p.L485F|EXOC5_uc010trh.1_Missense_Mutation_p.L475F	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein	540					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3						TCATACAATTTAATGTCCTAG	0.269													6	30					0	0	0	0	G	57676773	G	G	57676773	3	3	57	1	0	0	0	0	1	0	0	0	5331	1751	61	5	518	5	EXOC5	14	57676773	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	7363813	57676773	49672767	118	11327											
ZFP36L1	677	broad.mit.edu	37	chr14	69256577	69256577	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggtcatcggcgctcagaatAgggggtggggtgatggacgt	8	8	19	6	3	2	2	2	1	0	1	3	3	2	3	0	7	0	1	0	7	2	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr14:69256577A>T	uc001xkh.1	-	2	820	c.690T>A	c.(688-690)CCT>CCA	p.P230P	ZFP36L1_uc001xki.1_Silent_p.P230P	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	230					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CGCTCAGAATAGGGGGTGGGG	0.532											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	197					0	0	0	0	T	69256577	T	T	69256577	2	4	57	1	0	0	0	0	0	0	0	1	17713	407	15	5		5	ZFP36L1	14	69256577	Silent	SNP	A	TCGA-CN-5359-01A-01D-1434-08	11579804	69256577	38092963	119	11328											
MKRN3	7681	broad.mit.edu	37	chr15	23811027	23811027	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtgtctgggccggaccttcCcgtctgtgagccctccgggg	2	10	15	14	3	2	1	0	1	2	0	4	2	4	2	5	4	1	0	5	4	0	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:23811027C>T	uc001ywh.3	+	1	574	c.98C>T	c.(97-99)CCC>CTC	p.P33L	MKRN3_uc001ywi.2_Missense_Mutation_p.P33L|MKRN3_uc010ayi.1_Missense_Mutation_p.P33L	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	33						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding	p.P33P(1)		lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CCGGACCTTCCCGTCTGTGAG	0.682													8	91					0	0	0	0	T	23811027	T	T	23811027	3	4	57	1	0	0	0	0	1	0	0	0	9661	623	22	4	100	4	MKRN3	15	23811027	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08		23811027	78720365	120	11329											
RPUSD2	27079	broad.mit.edu	37	chr15	40866110	40866110	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagcctggatgtgctagatCtctgtgagggtgacctgtcc	7	11	14	9	0	1	4	0	2	1	2	3	5	2	5	3	2	2	1	3	2	1	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:40866110C>A	uc001zmd.1	+	3	1288	c.1288C>A	c.(1288-1290)CTC>ATC	p.L430I		NM_152260	NP_689473	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing	430					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			skin(1)	1		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		TGTGCTAGATCTCTGTGAGGG	0.597													16	123					1.15919e-05	1.32391e-05	1	0	A	40866110	A	A	40866110	3	1	57	1	0	0	0	0	1	0	0	0	13732	913	32	2	1298	2	RPUSD2	15	40866110	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	17055083	40866110	61665282	121	11330											
VPS13C	54832	broad.mit.edu	37	chr15	62254687	62254701	+	In_Frame_Del	DEL	ATACAAATCCAAATT	-	-																															tccccctcagtagcatctggAtacaaatccaaattaaaacg																										TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:62254687_62254701delATACAAATCCAAATT	uc002agz.2	-	34	3546_3560	c.3472_3486delAATTTGGATTTGTAT	c.(3472-3486)AATTTGGATTTGTATdel	p.NLDLY1158del	VPS13C_uc002aha.2_In_Frame_Del_p.NLDLY1115del|VPS13C_uc002ahb.1_In_Frame_Del_p.NLDLY1158del|VPS13C_uc002ahc.1_In_Frame_Del_p.NLDLY1115del	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1158_1162					protein localization					ovary(2)	2						TAGCATCTGGATACAAATCCAAATTAAAACGGAAA	0.367													---	---	---								-	62254701	-	-	62254687	7	5	57	1	0	1	0	1	0	0	0	0	17259	340	12	0	8011	0	VPS13C	15	62254687	In_Frame_Del	DEL	ATACAAATCCAAATT	TCGA-CN-5359-01A-01D-1434-08	21388577	62254687	40276705	122	11331											
RASGRF1	5923	broad.mit.edu	37	chr15	79254558	79254558	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcatccattacaaaagattgGtccagtaaatattgcgttac	14	13	6	8	1	1	1	1	0	0	1	3	1	3	1	2	1	3	2	2	1	7	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:79254558G>T	uc002beq.2	-	28	4125	c.3750C>A	c.(3748-3750)GAC>GAA	p.D1250E	RASGRF1_uc002bep.2_Missense_Mutation_p.D1234E|RASGRF1_uc002beo.2_Missense_Mutation_p.D466E	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	1252	Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						CAAAAGATTGGTCCAGTAAAT	0.463													5	21					1.06961e-07	1.26145e-07	1	0	T	79254558	T	T	79254558	3	4	57	1	0	0	0	0	1	0	0	0	13137	1252	44	4	75	4	RASGRF1	15	79254558	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	16999871	79254558	23276834	123	11332											
MTHFS	10588	broad.mit.edu	37	chr15	80181668	80181668	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaaagatggaaattcttttgGacttttgatactcactgtgg	11	15	10	5	0	2	2	1	1	1	1	2	5	2	4	0	3	1	0	0	3	3	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:80181668G>A	uc002bex.3	-	2	186	c.146C>T	c.(145-147)TCC>TTC	p.S49F		NM_006441	NP_006432	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase	49					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding				0				all cancers(203;0.00467)		AATTCTTTTGGACTTTTGATA	0.378													8	179					0	0	0	0	A	80181668	A	A	80181668	3	1	57	1	0	0	0	0	1	0	0	0	9985	1174	41	2	473	2	MTHFS	15	80181668	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	927110	80181668	22349724	124	11333											
IL16	3603	broad.mit.edu	37	chr15	81592045	81592045	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaagccagcctggtttcGccaaagcttgaaaggtttga	10	10	10	11	1	0	2	0	2	0	0	2	2	1	2	4	2	3	3	4	2	3	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr15:81592045G>A	uc002bgh.3	+	14	2754	c.2378G>A	c.(2377-2379)CGC>CAC	p.R793H	IL16_uc010blq.1_Missense_Mutation_p.R747H|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.R835H|IL16_uc002bgg.2_Missense_Mutation_p.R793H|IL16_uc002bgi.1_Missense_Mutation_p.R183H|IL16_uc002bgj.2_Missense_Mutation_p.R287H|IL16_uc002bgk.2_Missense_Mutation_p.R92H|IL16_uc002bgl.1_Missense_Mutation_p.R92H|IL16_uc010unq.1_Missense_Mutation_p.R92H	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	793					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GCCTGGTTTCGCCAAAGCTTG	0.562													6	134					0	0	0	0	A	81592045	A	A	81592045	3	1	57	1	0	0	0	0	1	0	0	0	7672	1087	38	1	2428	1	IL16	15	81592045	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	1410377	81592045	20939347	125	11334											
RHBDF1	64285	broad.mit.edu	37	chr16	110495	110495	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcccgcaagctctggggCgctgggatggatgggccact	5	7	18	11	2	1	0	0	0	1	0	1	2	1	2	2	6	1	3	2	6	1	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr16:110495C>T	uc002cfl.3	-	15	1748	c.1600G>A	c.(1600-1602)GCC>ACC	p.A534T		NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	534	Lumenal (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				AGCTCTGGGGCGCTGGGATGG	0.632													11	113					0	0	0	0	T	110495	T	T	110495	3	4	57	1	0	0	0	0	1	0	0	0	13384	768	27	1	995	1	RHBDF1	16	110495	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08		110495	90244258	126	11335											
ABAT	18	broad.mit.edu	37	chr16	8866736	8866736	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggagacaaccacgcatccGatgacttctttcggaagctg	10	9	11	11	3	1	2	0	1	1	1	3	5	2	3	2	2	2	2	2	2	2	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr16:8866736G>A	uc002czc.3	+	12	1082	c.916G>A	c.(916-918)GAT>AAT	p.D306N	ABAT_uc002czd.3_Missense_Mutation_p.D306N|ABAT_uc010buh.2_Missense_Mutation_p.D248N|ABAT_uc010bui.2_Missense_Mutation_p.D306N	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	306					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	CCACGCATCCGATGACTTCTT	0.552													5	56					0	0	0	0	A	8866736	A	A	8866736	3	1	57	1	0	0	0	0	1	0	0	0	27	1058	37	1	958	1	ABAT	16	8866736	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	8756241	8866736	81488017	127	11336											
ABCC1	4363	broad.mit.edu	37	chr16	16101762	16101762	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggtgccttgtttttacctCtgggcctgtttccccttcta	2	18	9	12	0	2	0	0	0	2	0	3	0	3	0	5	2	2	2	5	2	2	7			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr16:16101762C>T	uc010bvi.2	+	2	313	c.138C>T	c.(136-138)CTC>CTT	p.L46L	ABCC1_uc010bvj.2_Silent_p.L46L|ABCC1_uc010bvk.2_Silent_p.L46L|ABCC1_uc010bvl.2_Silent_p.L46L|ABCC1_uc010bvm.2_Silent_p.L46L|ABCC1_uc002del.3_5'Flank	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	46	Helical; Name=1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTTTTTACCTCTGGGCCTGTT	0.507													16	201					0	0	0	0	T	16101762	T	T	16101762	2	4	57	1	0	0	0	0	0	0	0	1	49	900	32	2		2	ABCC1	16	16101762	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	7235026	16101762	74252991	128	11337											
PRKCB	5579	broad.mit.edu	37	chr16	24192240	24192240	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggcactccagactacatCgcccccgaggtgagagctgc	8	7	12	14	2	0	2	0	1	0	2	2	4	1	2	3	2	3	2	3	2	1	1	rs17847876		TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr16:24192240C>A	uc002dmd.2	+	13	1721	c.1524C>A	c.(1522-1524)ATC>ATA	p.I508I	PRKCB_uc002dme.2_Silent_p.I508I	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	508	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CAGACTACATCGCCCCCGAGG	0.542													15	130					7.93312e-07	9.15685e-07	1	0	A	24192240	A	A	24192240	2	1	57	1	0	0	0	0	0	0	0	1	12570	874	31	3		3	PRKCB	16	24192240	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	8090478	24192240	66162513	129	11338											
NAE1	8883	broad.mit.edu	37	chr16	66837006	66837006	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgattattttgatgaccTcttgagcagcagctcctgaa	9	14	10	8	0	1	5	0	5	1	0	2	5	2	5	2	1	3	3	2	1	2	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr16:66837006T>C	uc002eqf.2	-	20	1588	c.1511A>G	c.(1510-1512)GAG>GGG	p.E504G	NAE1_uc002eqe.2_Missense_Mutation_p.E498G|NAE1_uc002eqg.2_Missense_Mutation_p.E415G|NAE1_uc010cdv.2_Missense_Mutation_p.E507G|CCDC79_uc010viv.1_5'Flank|CCDC79_uc002eqc.1_5'Flank|CCDC79_uc002eqd.1_5'Flank	NM_003905	NP_003896	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform a	504					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TTTGATGACCTCTTGAGCAGC	0.328													7	63					0	0	0	0	C	66837006	C	C	66837006	3	2	57	1	0	0	0	0	1	0	0	0	10192	1551	54	5	97	5	NAE1	16	66837006	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	42644766	66837006	23517747	130	11339											
TP53	7157	broad.mit.edu	37	chr17	7578247	7578247	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccaaatactccacacgcAaatttccttccactcggata	13	10	3	15	2	0	0	0	0	0	0	5	1	4	1	4	1	1	1	4	1	4	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:7578247A>T	uc002gim.2	-	6	796	c.602T>A	c.(601-603)TTG>TAG	p.L201*	TP53_uc002gig.1_Nonsense_Mutation_p.L201*|TP53_uc002gih.2_Nonsense_Mutation_p.L201*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.L69*|TP53_uc010cng.1_Nonsense_Mutation_p.L69*|TP53_uc002gii.1_Nonsense_Mutation_p.L69*|TP53_uc010cnh.1_Nonsense_Mutation_p.L201*|TP53_uc010cni.1_Nonsense_Mutation_p.L201*|TP53_uc002gij.2_Nonsense_Mutation_p.L201*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.L108*|TP53_uc002gio.2_Nonsense_Mutation_p.L69*|TP53_uc010vug.1_Nonsense_Mutation_p.L162*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	201	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> S (in a sporadic cancer; somatic mutation).|LR -> FC (in a sporadic cancer; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L201F(7)|p.L201fs*46(4)|p.K164_P219del(1)|p.E198_L201>V(1)|p.N200fs*4(1)|p.L201P(1)|p.L201S(1)|p.E198fs*7(1)|p.L201fs*8(1)|p.P191fs*6(1)|p.L201_R202>FC(1)|p.L201L(1)|p.G199fs*42(1)|p.L201*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCCACACGCAAATTTCCTTC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	64					0	0	0	0	T	7578247	T	T	7578247	4	4	57	1	0	0	0	0	0	1	0	0	16448	131	5	5	692	5	TP53	17	7578247	Nonsense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08		7578247	73616963	131	11340											
PFAS	5198	broad.mit.edu	37	chr17	8170877	8170877	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccttcgcaggtatgggaCgtgaccatgcaggacctctg	8	8	12	13	2	1	1	0	1	1	0	2	3	1	3	4	3	1	3	4	3	1	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:8170877C>T	uc002gkr.2	+	26	3417	c.3276C>T	c.(3274-3276)GAC>GAT	p.D1092D	PFAS_uc010vuv.1_Silent_p.D668D|PFAS_uc002gks.2_Silent_p.D171D	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	1092	Glutamine amidotransferase type-1.				'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AGGTATGGGACGTGACCATGC	0.637													18	155					0	0	0	0	T	8170877	T	T	8170877	2	4	57	1	0	0	0	0	0	0	0	1	11809	535	19	1		1	PFAS	17	8170877	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	592630	8170877	73024333	132	11341											
CDRT1	374286	broad.mit.edu	37	chr17	15522822	15522822	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagccttgattccaggtttTccatgatcctaagataacca	11	13	7	10	0	0	4	0	3	0	1	3	4	3	4	5	1	2	1	5	1	2	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:15522822T>C	uc002gov.3	-	1	197	c.5A>G	c.(4-6)GAA>GGA	p.E2G	TRIM16_uc002gor.1_Intron	NM_006382	NP_006373	O95170	CDRT1_HUMAN	CMT1A duplicated region transcript 1	2											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(2;1.36e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0541)		TTCCAGGTTTTCCATGATCCT	0.498													10	486					0	0	0	0	C	15522822	C	C	15522822	3	2	57	1	0	0	0	0	1	0	0	0	3189	1783	62	5	2301	5	CDRT1	17	15522822	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	7351945	15522822	65672388	133	11342											
SEBOX	645832	broad.mit.edu	37	chr17	26691847	26691847	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcctcaggaaggcaagtgacCcaggccaggtgctcatgggt	9	6	15	11	0	2	1	2	1	0	0	2	2	2	2	3	5	1	2	3	5	2	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:26691847C>T	uc010wai.1	-	2	254	c.240G>A	c.(238-240)TGG>TGA	p.W80*	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_Nonsense_Mutation_p.W79*|SARM1_uc010waj.1_Intron	NM_001080837	NP_001074306	Q9HB31	SEBOX_HUMAN	SEBOX homeobox isoform 1	80	Homeobox.				cell differentiation|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		GGCAAGTGACCCAGGCCAGGT	0.607													4	53					0	0	0	0	T	26691847	T	T	26691847	4	4	57	1	0	0	0	0	0	1	0	0	14042	624	22	4	418	4	SEBOX	17	26691847	Nonsense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	11169025	26691847	54503363	134	11343											
FOXN1	8456	broad.mit.edu	37	chr17	26862068	26862068	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accccccaggactcgcctctGcctgcccacaccccacccag	7	4	6	24	1	1	0	0	0	1	0	2	1	1	1	9	1	2	0	9	1	0	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:26862068G>T	uc010crm.2	+	8	1677	c.1479G>T	c.(1477-1479)CTG>CTT	p.L493L	FOXN1_uc002hbj.2_Silent_p.L493L	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	493					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					ACTCGCCTCTGCCTGCCCACA	0.692													25	68					1.1804e-14	1.48061e-14	1	0	T	26862068	T	T	26862068	2	4	57	1	0	0	0	0	0	0	0	1	6053	1306	46	4		4	FOXN1	17	26862068	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	170221	26862068	54333142	135	11344											
SLFN13	146857	broad.mit.edu	37	chr17	33767957	33767957	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtcactatttgctccaaaGtaaagtttttaataatcttt	13	17	5	6	0	2	0	1	0	1	0	3	0	3	0	1	1	1	3	1	1	6	8			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:33767957G>T	uc002hjk.1	-	4	2681	c.2351C>A	c.(2350-2352)ACT>AAT	p.T784N	SLFN13_uc010wch.1_Missense_Mutation_p.T784N|SLFN13_uc002hjl.2_Missense_Mutation_p.T784N|SLFN13_uc010ctt.2_Missense_Mutation_p.T466N|SLFN13_uc002hjm.2_Missense_Mutation_p.T453N	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	784						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TTGCTCCAAAGTAAAGTTTTT	0.443													34	103					1.61788e-16	2.06518e-16	1	0	T	33767957	T	T	33767957	3	4	57	1	0	0	0	0	1	0	0	0	14800	1029	36	4	346	4	SLFN13	17	33767957	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	6905889	33767957	47427253	136	11345											
TAF15	8148	broad.mit.edu	37	chr17	34171147	34171147	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaccccaaaagtggggattGggtttgccctaatccgtaag	11	9	12	9	1	0	1	0	0	0	1	1	2	1	2	4	3	1	2	4	3	4	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:34171147G>T	uc002hkd.2	+	13	1159	c.1073G>T	c.(1072-1074)TGG>TTG	p.W358L	TAF15_uc010ctw.1_RNA|TAF15_uc002hkc.2_Missense_Mutation_p.W355L	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	358	RanBP2-type.|Arg/Gly-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		AGTGGGGATTGGGTTTGCCCT	0.527			T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								17	212					1.45105e-14	1.80964e-14	1	0	T	34171147	T	T	34171147	3	4	57	1	0	0	0	0	1	0	0	0	15584	1357	47	4	1123	4	TAF15	17	34171147	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	403190	34171147	47024063	137	11346											
GRN	2896	broad.mit.edu	37	chr17	42428419	42428419	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actcaggccacctgctgctcCgatcacctgcactgctgccc	6	8	8	19	1	2	0	2	0	0	0	3	1	3	0	5	1	5	4	5	1	0	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:42428419C>T	uc002igp.1	+	8	942	c.723C>T	c.(721-723)TCC>TCT	p.S241S	GRN_uc002igr.1_Silent_p.S35S	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	241					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CCTGCTGCTCCGATCACCTGC	0.607											OREG0024459	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	116					0	0	0	0	T	42428419	T	T	42428419	2	4	57	1	0	0	0	0	0	0	0	1	6843	639	23	1		1	GRN	17	42428419	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	8257272	42428419	38766791	138	11347											
HOXB1	3211	broad.mit.edu	37	chr17	46607812	46607812	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatcagcataggccggtgcaAagctcgcggtctgctcgttc	7	9	13	12	4	2	0	1	0	1	0	5	1	2	0	1	3	4	5	1	3	2	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:46607812A>C	uc002ink.1	-	1	461	c.455T>G	c.(454-456)TTT>TGT	p.F152C		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	152						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCCGGTGCAAAGCTCGCGGT	0.622													9	85					0	0	0	0	C	46607812	C	C	46607812	3	2	57	1	0	0	0	0	1	0	0	0	7338	14	1	5	458	5	HOXB1	17	46607812	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	4179393	46607812	34587398	139	11348											
HOXB6	3216	broad.mit.edu	37	chr17	46673816	46673816	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcctcctcggcactgagctGagacgcgctgagcagtttgc	6	9	12	14	3	0	3	0	3	0	1	3	4	2	3	2	1	3	5	2	1	0	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:46673816G>A	uc002ins.1	-	4	959	c.634C>T	c.(634-636)CAG>TAG	p.Q212*	HOXB5_uc002inr.2_5'Flank|HOXB6_uc010dbh.1_Nonsense_Mutation_p.Q212*|HOXB6_uc002int.1_3'UTR	NM_018952	NP_061825	P17509	HXB6_HUMAN	homeobox B6	212					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCACTGAGCTGAGACGCGCTG	0.602													7	391					0	0	0	0	A	46673816	A	A	46673816	4	1	57	1	0	0	0	0	0	1	0	0	7344	1299	45	2	44	2	HOXB6	17	46673816	Nonsense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	66004	46673816	34521394	140	11349											
CSHL1	1444	broad.mit.edu	37	chr17	61987866	61987866	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggagtcatgcaggaatgAatacttctgttcctttgtga	9	14	11	7	0	2	2	1	2	1	0	3	4	3	4	1	2	2	2	1	2	3	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:61987866A>C	uc002jda.1	-	3	282	c.220T>G	c.(220-222)TCA>GCA	p.S74A	CSHL1_uc002jcz.1_Intron|CSHL1_uc002jdb.1_Translation_Start_Site|CSHL1_uc002jdc.1_Intron|CSHL1_uc002jdd.1_Intron|CSHL1_uc002jde.2_Missense_Mutation_p.I171M|CSHL1_uc002jdf.2_Intron|CSHL1_uc002jdg.2_Missense_Mutation_p.I143M|CSHL1_uc002jdh.2_Translation_Start_Site	NM_022579	NP_072101	Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	74						extracellular region	hormone activity|metal ion binding				0						TGCAGGAATGAATACTTCTGT	0.507													15	248					0	0	0	0	C	61987866	C	C	61987866	3	2	57	1	0	0	0	0	1	0	0	0	3959	246	9	5	460	5	CSHL1	17	61987866	Missense_Mutation	SNP	A	TCGA-CN-5359-01A-01D-1434-08	15314050	61987866	19207344	141	11350											
ERN1	2081	broad.mit.edu	37	chr17	62144284	62144284	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaccattggacacaaagtGggacatctctgtacagatca	14	9	8	10	0	3	1	2	0	1	1	4	3	3	3	1	2	1	1	1	2	2	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr17:62144284G>C	uc002jdz.2	-	8	702	c.589C>G	c.(589-591)CAC>GAC	p.H197D		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	197	Lumenal (Potential).				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						GACACAAAGTGGGACATCTCT	0.502													3	39					0	0	0	0	C	62144284	C	C	62144284	3	2	57	1	0	0	0	0	1	0	0	0	5261	1348	47	4	2404	4	ERN1	17	62144284	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	156418	62144284	19050926	142	11351											
ZNF519	162655	broad.mit.edu	37	chr18	14105333	14105333	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattccttacacttgaaaggTttctctccagtatgcattct	9	16	5	11	0	2	1	0	1	2	0	5	1	4	1	2	1	2	3	2	1	3	6			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr18:14105333T>C	uc002kst.1	-	3	1359	c.1206A>G	c.(1204-1206)AAA>AAG	p.K402K	ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTTGAAAGGTTTCTCTCCAG	0.403													6	216					0	0	0	0	C	14105333	C	C	14105333	2	2	57	1	0	0	0	0	0	0	0	1	18031	1722	60	5		5	ZNF519	18	14105333	Silent	SNP	T	TCGA-CN-5359-01A-01D-1434-08		14105333	63971915	143	11352											
DSG2	1829	broad.mit.edu	37	chr18	29110982	29110982	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaaatgaagaatcttgaCttcagtgttattgtcgctaa	14	13	9	5	1	2	4	1	2	1	2	3	5	2	4	0	0	0	2	0	0	6	5			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr18:29110982C>T	uc002kwu.3	+	9	1235	c.1047C>T	c.(1045-1047)GAC>GAT	p.D349D		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	349	Extracellular (Potential).|Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGAATCTTGACTTCAGTGTTA	0.343													40	110					0	0	0	0	T	29110982	T	T	29110982	2	4	57	1	0	0	0	0	0	0	0	1	4799	564	20	4		4	DSG2	18	29110982	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	15005649	29110982	48966266	144	11353											
ALPK2	115701	broad.mit.edu	37	chr18	56278955	56278955	+	Frame_Shift_Del	DEL	C	-	-																															cgaagcacagcgtctgacttCtcaggaaccttctgggaaag																										TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr18:56278955delC	uc002lhj.3	-	2	289	c.75delG	c.(73-75)GAGfs	p.E25fs		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	25	Ig-like 1.						ATP binding|protein serine/threonine kinase activity	p.E25K(1)		ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CGTCTGACTTCTCAGGAACCT	0.483													---	---	---								-	56278955	-	-	56278955	7	5	57	1	0	1	0	1	0	0	0	0	545	912	32	0	6485	0	ALPK2	18	56278955	Frame_Shift_Del	DEL	C	TCGA-CN-5359-01A-01D-1434-08	27167973	56278955	21798293	145	11354											
AES	166	broad.mit.edu	37	chr19	3055690	3055690	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agaggtagggcaggacctggGcacaaatcccgttcagcctt	10	7	13	11	1	1	1	1	0	0	1	2	2	2	2	3	4	1	4	3	4	2	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:3055690G>C	uc002lwy.1	-	5	442	c.269C>G	c.(268-270)GCC>GGC	p.A90G	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Missense_Mutation_p.A90G|AES_uc002lxa.1_Missense_Mutation_p.A34G|AES_uc002lxb.1_Missense_Mutation_p.A157G|AES_uc002lxc.2_Missense_Mutation_p.A157G	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	90	Gln-rich (Q domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGACCTGGGCACAAATCCC	0.637													9	114					0	0	0	0	C	3055690	C	C	3055690	3	2	57	1	0	0	0	0	1	0	0	0	352	1203	42	4	336	4	AES	19	3055690	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08		3055690	56073293	146	11355											
TJP3	27134	broad.mit.edu	37	chr19	3735583	3735583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagagtccccggcttcggCgggaaagttcagtagattcc	8	8	15	10	3	1	2	1	0	0	2	4	4	3	3	3	4	0	3	3	4	2	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:3735583C>T	uc010xhv.1	+	8	1105	c.1105C>T	c.(1105-1107)CGG>TGG	p.R369W	TJP3_uc010xhs.1_Missense_Mutation_p.R336W|TJP3_uc010xht.1_Missense_Mutation_p.R300W|TJP3_uc010xhu.1_Missense_Mutation_p.R345W|TJP3_uc010xhw.1_Missense_Mutation_p.R355W	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	350						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGCTTCGGCGGGAAAGTTC	0.493													21	206					0	0	0	0	T	3735583	T	T	3735583	3	4	57	1	0	0	0	0	1	0	0	0	15997	759	27	1	1135	1	TJP3	19	3735583	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	679893	3735583	55393400	147	11356											
TMIGD2	126259	broad.mit.edu	37	chr19	4292705	4292705	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgggcctggggctggggCagggtctcgggctggggcag	2	5	24	10	2	1	0	0	0	1	0	2	0	1	0	2	10	0	4	2	10	0	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:4292705C>A	uc002lzx.1	-	5	786	c.740G>T	c.(739-741)TGC>TTC	p.C247F	TMIGD2_uc010dtv.1_Missense_Mutation_p.C243F	NM_144615	NP_653216	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain	247	Pro-rich.|Cytoplasmic (Potential).					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		ggggctggggcagggtctcgg	0.493													7	88					0.00307968	0.00330837	1	0	A	4292705	A	A	4292705	3	1	57	1	0	0	0	0	1	0	0	0	16297	710	25	4	112	4	TMIGD2	19	4292705	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	557122	4292705	54836278	148	11357											
LRRC8E	80131	broad.mit.edu	37	chr19	7964965	7964965	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctggaggggcttttccccCaggagctagctcgggcagcc	6	7	14	14	1	0	0	0	0	0	0	2	2	1	2	4	5	3	4	4	5	1	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:7964965C>T	uc002mir.2	+	3	1659	c.1558C>T	c.(1558-1560)CAG>TAG	p.Q520*		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	520	LRR 1.					integral to membrane				lung(1)|pancreas(1)	2						GCTTTTCCCCCAGGAGCTAGC	0.657													5	32					0	0	0	0	T	7964965	T	T	7964965	4	4	57	1	0	0	0	0	0	1	0	0	9075	595	21	4	1564	4	LRRC8E	19	7964965	Nonsense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	3672260	7964965	51164018	149	11358											
LASS4	79603	broad.mit.edu	37	chr19	8321168	8321168	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgggacaggtacccaaacCaggtgagtggcagagtgtgt	10	7	16	8	0	0	2	0	1	0	1	0	3	0	3	2	4	2	3	2	4	2	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:8321168C>A	uc002mjg.2	+	7	837	c.517C>A	c.(517-519)CAG>AAG	p.Q173K	LASS4_uc002mjh.2_Missense_Mutation_p.Q122K|LASS4_uc002mji.2_Missense_Mutation_p.Q9K|LASS4_uc010dvz.2_Missense_Mutation_p.Q173K	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	LAG1 homolog, ceramide synthase 4	173	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(1)	1						GTACCCAAACCAGGTGAGTGG	0.572													5	31					3.59834e-05	4.06687e-05	1	0	A	8321168	A	A	8321168	3	1	57	1	0	0	0	0	1	0	0	0	8681	595	21	4	535	4	LASS4	19	8321168	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	356203	8321168	50807815	150	11359											
ANGPTL4	51129	broad.mit.edu	37	chr19	8436298	8436298	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcactgcacccgtggccggcCagctgggcgccaccaccgtc	5	5	12	19	4	1	0	1	0	0	0	2	0	1	0	6	3	2	2	6	3	0	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:8436298C>A	uc002mjq.1	+	6	1126	c.931C>A	c.(931-933)CAG>AAG	p.Q311K	ANGPTL4_uc002mjr.1_Missense_Mutation_p.Q273K|ANGPTL4_uc010xkc.1_Missense_Mutation_p.Q144K	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	311	Fibrinogen C-terminal.				angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						CGTGGCCGGCCAGCTGGGCGC	0.672													6	55					8.12818e-05	9.04521e-05	1	0	A	8436298	A	A	8436298	3	1	57	1	0	0	0	0	1	0	0	0	616	595	21	4	953	4	ANGPTL4	19	8436298	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	115130	8436298	50692685	151	11360											
KEAP1	9817	broad.mit.edu	37	chr19	10602764	10602764	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggcgtcaacgagtggcagcGcacggcccgcagcagcgcct	7	3	15	16	7	1	0	1	0	0	0	1	1	1	0	2	3	4	4	2	3	1	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:10602764G>A	uc002moq.1	-	3	970	c.814C>T	c.(814-816)CGC>TGC	p.R272C	KEAP1_uc002mop.1_5'UTR|KEAP1_uc002mor.1_Missense_Mutation_p.R272C	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	272	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GAGTGGCAGCGCACGGCCCGC	0.617													10	60					0	0	0	0	A	10602764	A	A	10602764	3	1	57	1	0	0	0	0	1	0	0	0	8180	1087	38	1	1076	1	KEAP1	19	10602764	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	2166466	10602764	48526219	152	11361											
QTRT1	81890	broad.mit.edu	37	chr19	10822906	10822906	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgagagcaagtcgcagtTctggcggatggtggcgctga	7	8	19	7	3	1	2	0	2	1	1	2	4	1	3	0	5	1	4	0	5	1	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:10822906T>G	uc002mpr.2	+	6	741	c.716T>G	c.(715-717)TTC>TGC	p.F239C	DNM2_uc010dxk.2_5'Flank	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	239					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			AAGTCGCAGTTCTGGCGGATG	0.622													10	107					0	0	0	0	G	10822906	G	G	10822906	3	3	57	1	0	0	0	0	1	0	0	0	12950	1783	62	5	738	5	QTRT1	19	10822906	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	220142	10822906	48306077	153	11362											
DNAJB1	3337	broad.mit.edu	37	chr19	14627517	14627517	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtttagccgcttgtgggagaTtttcatcttcttggtacagc	6	16	11	8	1	3	1	1	0	2	1	3	2	3	1	1	2	3	3	1	2	2	8			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:14627517T>C	uc002myz.1	-	2	593	c.553A>G	c.(553-555)ATC>GTC	p.I185V	DNAJB1_uc010xnr.1_Missense_Mutation_p.I85V	NM_006145	NP_006136	P25685	DNJB1_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 1	185					chaperone cofactor-dependent protein refolding|response to unfolded protein	cytoplasm|nucleolus	heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(1328;0.0476)		TTGTGGGAGATTTTCATCTTC	0.502													30	341					0	0	0	0	C	14627517	C	C	14627517	3	2	57	1	0	0	0	0	1	0	0	0	4637	1493	52	5	477	5	DNAJB1	19	14627517	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	3804611	14627517	44501466	154	11363											
ZNF737	100129842	broad.mit.edu	37	chr19	20728598	20728598	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attttgctttgagtagttgtCaaatattggttaagtccatt	10	19	8	4	0	1	1	1	1	0	0	2	1	2	1	1	1	1	4	1	1	4	9			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:20728598C>G	uc002npa.2	-	4	591	c.411G>C	c.(409-411)TTG>TTC	p.L137F		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	137					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GAGTAGTTGTCAAATATTGGT	0.299													8	47					0	0	0	0	G	20728598	G	G	20728598	3	3	57	1	0	0	0	0	1	0	0	0	18193	825	29	2	1203	2	ZNF737	19	20728598	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	6101081	20728598	38400385	155	11364											
CCDC123	84902	broad.mit.edu	37	chr19	33370188	33370188	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctggggttgtcctgcacGcctgtcctcgtgagtgtgtc	2	13	14	12	2	1	1	0	1	1	0	5	1	3	1	3	2	1	3	3	2	0	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:33370188G>A	uc002nty.2	-	19	2321	c.2232C>T	c.(2230-2232)GGC>GGT	p.G744G	CCDC123_uc002ntx.2_Silent_p.G497G|CCDC123_uc010edg.2_RNA	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	744						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					TGTCCTGCACGCCTGTCCTCG	0.537													21	255					0	0	0	0	A	33370188	A	A	33370188	2	1	57	1	0	0	0	0	0	0	0	1	2771	1074	38	1		1	CCDC123	19	33370188	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	12641590	33370188	25758795	156	11365											
CYP2S1	29785	broad.mit.edu	37	chr19	41712380	41712380	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgaccttcactccaccaCgcagaccagatgaaggaagg	13	5	9	14	1	1	4	1	2	0	2	2	5	2	5	4	2	0	1	4	2	2	1			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:41712380C>G	uc002opw.2	+	9	1557	c.1502C>G	c.(1501-1503)ACG>AGG	p.T501R	CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Missense_Mutation_p.T226R	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S,	501					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1						CACTCCACCACGCAGACCAGA	0.602													17	207					0	0	0	0	G	41712380	G	G	41712380	3	3	57	1	0	0	0	0	1	0	0	0	4191	536	19	3	1536	3	CYP2S1	19	41712380	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	8342192	41712380	17416603	157	11366											
ZNF229	7772	broad.mit.edu	37	chr19	44933099	44933099	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctctccagtgtggaccctCtgatggataaggaggtcgga	8	11	13	9	1	2	1	0	1	2	0	5	5	3	5	2	5	0	0	2	5	1	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:44933099C>A	uc002oze.1	-	6	2291	c.1857G>T	c.(1855-1857)CAG>CAT	p.Q619H	ZNF229_uc010ejk.1_Missense_Mutation_p.Q273H|ZNF229_uc010ejl.1_Missense_Mutation_p.Q613H	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	619	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				TGTGGACCCTCTGATGGATAA	0.547													11	156					3.86212e-05	4.34238e-05	1	0	A	44933099	A	A	44933099	3	1	57	1	0	0	0	0	1	0	0	0	17849	912	32	2	624	2	ZNF229	19	44933099	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	3220719	44933099	14195884	158	11367											
TTYH1	57348	broad.mit.edu	37	chr19	54946764	54946764	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcctgtgcgaagacgccctgGaaggcctgctcttcctgcta	6	9	12	14	2	1	1	0	0	1	1	2	3	2	2	4	2	3	2	4	2	3	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:54946764G>A	uc002qfq.2	+	11	1260	c.1168G>A	c.(1168-1170)GAA>AAA	p.E390K	TTYH1_uc010yey.1_Missense_Mutation_p.G420E|TTYH1_uc002qfr.2_Missense_Mutation_p.E390K|TTYH1_uc002qft.2_Missense_Mutation_p.E390K	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	390	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		AGACGCCCTGGAAGGCCTGCT	0.687													8	87					0	0	0	0	A	54946764	A	A	54946764	3	1	57	1	0	0	0	0	1	0	0	0	16807	1175	41	2	1210	2	TTYH1	19	54946764	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	10013665	54946764	4182219	159	11368											
LILRA1	11024	broad.mit.edu	37	chr19	55105660	55105660	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtgtctctgtcctgccAgcaccgagggctcatccatc	5	11	10	15	1	2	0	1	0	1	0	6	1	4	0	4	1	2	2	4	1	0	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:55105660A>T	uc002qgh.1	+	2	135	c.-47_splice	c.e2-2		LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_5'Flank	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,						cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CTGTCCTGCCAGCACCGAGGG	0.582													11	94					0	0	0	0	T	55105660	T	T	55105660	5	4	57	1	0	0	0	0	0	0	1	0	8825	202	7	5		5	LILRA1	19	55105660	Splice_Site	SNP	A	TCGA-CN-5359-01A-01D-1434-08	158896	55105660	4023323	160	11369											
BRSK1	84446	broad.mit.edu	37	chr19	55815119	55815119	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagtccatggaagtcctgaGcatcaccgatgccgggggtg	9	7	15	10	2	1	1	1	1	0	0	3	4	3	2	4	3	2	1	4	3	2	0			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:55815119G>A	uc002qkg.2	+	12	1488	c.1211G>A	c.(1210-1212)AGC>AAC	p.S404N	BRSK1_uc002qkf.2_Missense_Mutation_p.S420N|BRSK1_uc002qkh.2_Missense_Mutation_p.S99N	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	404					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GAAGTCCTGAGCATCACCGAT	0.662													11	158					0	0	0	0	A	55815119	A	A	55815119	3	1	57	1	0	0	0	0	1	0	0	0	1528	971	34	4	1257	4	BRSK1	19	55815119	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	709459	55815119	3313864	161	11370											
PEG3	5178	broad.mit.edu	37	chr19	57325826	57325835	+	Frame_Shift_Del	DEL	AGCTCCTTTG	-	-																															ttgcattcatagaatggtatAgctcctttgaggggctcagt																										TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:57325826_57325835delAGCTCCTTTG	uc002qnu.2	-	7	4326_4335	c.3975_3984delCAAAGGAGCT	c.(3973-3984)CTCAAAGGAGCTfs	p.L1325fs	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Frame_Shift_Del_p.L1296fs|PEG3_uc002qnv.2_Frame_Shift_Del_p.L1325fs|PEG3_uc002qnw.2_Frame_Shift_Del_p.L1201fs|PEG3_uc002qnx.2_Frame_Shift_Del_p.L1199fs|PEG3_uc010etr.2_Frame_Shift_Del_p.L1325fs	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1325_1328					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGAATGGTATAGCTCCTTTGAGGGGCTCAG	0.429													---	---	---								-	57325835	-	-	57325826	7	5	57	1	0	1	0	1	0	0	0	0	11774	407	15	0	786	0	PEG3	19	57325826	Frame_Shift_Del	DEL	AGCTCCTTTG	TCGA-CN-5359-01A-01D-1434-08	1510707	57325826	1803157	162	11371											
USP29	57663	broad.mit.edu	37	chr19	57641043	57641043	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttattatgaccttgaccCagctgcttgctttgaaagat	9	15	7	10	0	1	4	0	3	1	1	1	4	1	4	2	0	3	3	2	0	3	5			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:57641043C>A	uc002qny.2	+	4	1356	c.1000C>A	c.(1000-1002)CAG>AAG	p.Q334K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	334					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GACCTTGACCCAGCTGCTTGC	0.378													19	198					7.45023e-12	9.13389e-12	1	0	A	57641043	A	A	57641043	3	1	57	1	0	0	0	0	1	0	0	0	17127	595	21	4	1002	4	USP29	19	57641043	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	315217	57641043	1487940	163	11372											
ZNF772	400720	broad.mit.edu	37	chr19	57985605	57985605	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcacacacatgtatggtttCtgccctgggtgtgtttcctg	6	14	11	10	0	1	0	0	0	1	0	2	0	2	0	2	2	2	4	2	2	1	3			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:57985605C>T	uc002qot.2	-	5	768	c.507G>A	c.(505-507)CAG>CAA	p.Q169Q	ZNF547_uc002qpm.3_Intron|ZNF772_uc010ygy.1_Silent_p.Q128Q|ZNF772_uc010ygz.1_Silent_p.Q57Q|ZNF772_uc010yha.1_Silent_p.Q115Q|ZNF772_uc002qou.2_Silent_p.Q57Q	NM_001024596	NP_001019767	Q68DY9	ZN772_HUMAN	zinc finger protein 772 isoform 1	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)|Lung(386;0.174)		TGTATGGTTTCTGCCCTGGGT	0.507													12	176					0	0	0	0	T	57985605	T	T	57985605	2	4	57	1	0	0	0	0	0	0	0	1	18212	912	32	2		2	ZNF772	19	57985605	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	344562	57985605	1143378	164	11373											
ZIK1	284307	broad.mit.edu	37	chr19	58101682	58101682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatgtcattgaagccctttcGcaaatgggaggttggaaagg	11	11	13	6	1	1	1	1	1	0	0	2	3	1	3	1	4	1	2	1	4	4	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr19:58101682G>A	uc002qpg.2	+	4	600	c.503G>A	c.(502-504)CGC>CAC	p.R168H	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Missense_Mutation_p.R113H|ZIK1_uc002qpi.2_Missense_Mutation_p.R155H|ZIK1_uc002qpj.2_Missense_Mutation_p.R65H	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAGCCCTTTCGCAAATGGGAG	0.502													5	81					0	0	0	0	A	58101682	A	A	58101682	3	1	57	1	0	0	0	0	1	0	0	0	17750	1087	38	1	517	1	ZIK1	19	58101682	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	116077	58101682	1027301	165	11374											
BTBD3	22903	broad.mit.edu	37	chr20	11903518	11903518	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgagttagctctcaagtCtgagggattctgcgatattg	8	13	13	7	1	3	2	1	2	3	0	4	4	3	3	0	2	2	3	0	2	3	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:11903518C>A	uc002wnz.2	+	4	1132	c.773C>A	c.(772-774)TCT>TAT	p.S258Y	BTBD3_uc002wny.2_Missense_Mutation_p.S197Y|BTBD3_uc002woa.2_Missense_Mutation_p.S197Y|BTBD3_uc010zrf.1_Missense_Mutation_p.S107Y|BTBD3_uc010zrg.1_Missense_Mutation_p.S107Y|BTBD3_uc010zrh.1_Missense_Mutation_p.S107Y	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	258										ovary(2)|central_nervous_system(1)	3						GCTCTCAAGTCTGAGGGATTC	0.517													13	117					1.49906e-05	1.70312e-05	1	0	A	11903518	A	A	11903518	3	1	57	1	0	0	0	0	1	0	0	0	1549	913	32	2	787	2	BTBD3	20	11903518	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08		11903518	51122002	166	11375											
KIF16B	55614	broad.mit.edu	37	chr20	16359952	16359952	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttatattgcagcctgtactCcactggctttattttctcga	7	18	6	10	1	1	0	0	0	1	0	3	1	2	0	2	1	3	3	2	1	4	9			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:16359952C>T	uc002wpg.1	-	19	2853	c.2695G>A	c.(2695-2697)GAG>AAG	p.E899K	KIF16B_uc002wpe.1_Missense_Mutation_p.E281K|KIF16B_uc002wpf.1_Missense_Mutation_p.E281K|KIF16B_uc010gch.1_Missense_Mutation_p.E899K|KIF16B_uc010gci.1_Missense_Mutation_p.E899K|KIF16B_uc010gcj.1_Missense_Mutation_p.E910K	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	899	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						AGCCTGTACTCCACTGGCTTT	0.413													16	217					0	0	0	0	T	16359952	T	T	16359952	3	4	57	1	0	0	0	0	1	0	0	0	8317	864	30	2	1290	2	KIF16B	20	16359952	Missense_Mutation	SNP	C	TCGA-CN-5359-01A-01D-1434-08	4456434	16359952	46665568	167	11376											
ENTPD6	955	broad.mit.edu	37	chr20	25205950	25205950	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcccaggagcaaagtgctGaaggtaagggtgccctcagg	10	8	14	9	0	1	1	1	1	0	0	2	2	2	2	2	4	3	3	2	4	3	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:25205950G>T	uc002wuj.2	+	14	1533	c.1353G>T	c.(1351-1353)CTG>CTT	p.L451L	ENTPD6_uc010zsz.1_Silent_p.L233L|ENTPD6_uc002wum.2_Silent_p.L434L|ENTPD6_uc010zta.1_Nonsense_Mutation_p.E466*|ENTPD6_uc002wun.2_Nonsense_Mutation_p.E432*|ENTPD6_uc002wuk.2_Silent_p.L450L|ENTPD6_uc002wul.2_Nonsense_Mutation_p.E465*|ENTPD6_uc010ztb.1_Nonsense_Mutation_p.E438*|ENTPD6_uc010ztc.1_Silent_p.L423L|ENTPD6_uc002wuo.2_Silent_p.L203L|ENTPD6_uc010ztd.1_Silent_p.L199L|ENTPD6_uc010gdk.1_RNA|ENTPD6_uc010gdl.1_RNA	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	451	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						GCAAAGTGCTGAAGGTAAGGG	0.612													9	41					0.000673444	0.000734359	1	0	T	25205950	T	T	25205950	2	4	57	1	0	0	0	0	0	0	0	1	5167	1277	45	2		2	ENTPD6	20	25205950	Silent	SNP	G	TCGA-CN-5359-01A-01D-1434-08	8845998	25205950	37819570	168	11377											
ZNF337	26152	broad.mit.edu	37	chr20	25666234	25666234	+	Frame_Shift_Del	DEL	T	-	-																															cctggccggcgtcttctctcTtctccccagggcacttcccc																										TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:25666234delT	uc002wva.2	-	3	741	c.219delA	c.(217-219)GAAfs	p.E73fs	ZNF337_uc010ztg.1_Intron|ZNF337_uc002wvb.2_Frame_Shift_Del_p.E73fs|ZNF337_uc002wvc.2_Frame_Shift_Del_p.E73fs	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	73	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTCTTCTCTCTTCTCCCCAGG	0.572													---	---	---								-	25666234	-	-	25666234	7	5	57	1	0	1	0	1	0	0	0	0	17920	1606	56	0	2044	0	ZNF337	20	25666234	Frame_Shift_Del	DEL	T	TCGA-CN-5359-01A-01D-1434-08	460284	25666234	37359286	169	11378											
PTPRT	11122	broad.mit.edu	37	chr20	40739003	40739003	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccactatgggcccagcttccGgggggttgaggaacttgacc	7	8	14	12	1	0	2	0	2	0	0	1	3	1	3	4	5	2	2	4	5	2	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:40739003G>A	uc002xkg.2	-	23	3408	c.3224C>T	c.(3223-3225)CCG>CTG	p.P1075L	PTPRT_uc010ggj.2_Missense_Mutation_p.P1094L|PTPRT_uc010ggi.2_Missense_Mutation_p.P278L	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1075	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCCAGCTTCCGGGGGGTTGAG	0.453													22	72					0	0	0	0	A	40739003	A	A	40739003	3	1	57	1	0	0	0	0	1	0	0	0	12877	1116	39	1	1137	1	PTPRT	20	40739003	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	15072769	40739003	22286517	170	11379											
EYA2	2139	broad.mit.edu	37	chr20	45725801	45725801	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggacatttgcatccagataCgggaaggtaagaatccattt	13	10	11	7	1	0	2	0	0	0	2	2	4	2	4	2	3	2	2	2	3	4	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr20:45725801C>T	uc002xsm.2	+	9	1256	c.882C>T	c.(880-882)TAC>TAT	p.Y294Y	EYA2_uc010ghp.2_Silent_p.Y294Y|EYA2_uc002xsn.2_Silent_p.Y299Y|EYA2_uc002xso.2_Silent_p.Y294Y|EYA2_uc002xsp.2_Silent_p.Y294Y|EYA2_uc002xsq.2_Silent_p.Y294Y	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	294					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				CATCCAGATACGGGAAGGTAA	0.423													29	275					0	0	0	0	T	45725801	T	T	45725801	2	4	57	1	0	0	0	0	0	0	0	1	5354	547	19	1		1	EYA2	20	45725801	Silent	SNP	C	TCGA-CN-5359-01A-01D-1434-08	4986798	45725801	17299719	171	11380											
ADAMTS5	11096	broad.mit.edu	37	chr21	28296445	28296446	+	Missense_Mutation	DNP	CG	TT	TT																															gacatccttttgctaacttcCggtttccatcctggcactgc																								rs75336666		TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr21:28296445_28296446CG>TT	uc002ymg.2	-	8	3448_3449	c.2719_2720CG>AA	c.(2719-2721)CGG>AAG	p.R907K		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	907	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TGCTAACTTCCGGTTTCCATCC	0.53													13	103					0	0	0	0	TT	28296446	TT	TT	28296445	3	4	57	1	0	0	0	0	1	0	0	0	269	652	23	1	76	1	ADAMTS5	21	28296445	Missense_Mutation	DNP	CG	TCGA-CN-5359-01A-01D-1434-08		28296445	19833450	172	11381											
RWDD2B	10069	broad.mit.edu	37	chr21	30380094	30380094	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcaaaccttgaccagaatTcttcacaggcactttgtggg	12	10	9	10	0	2	2	1	1	1	1	2	2	2	2	2	2	2	2	2	2	3	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr21:30380094T>A	uc002yms.2	-	4	800	c.713A>T	c.(712-714)GAA>GTA	p.E238V	RWDD2B_uc002ymt.2_Missense_Mutation_p.E209V|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Missense_Mutation_p.E158V	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	238											0						TGACCAGAATTCTTCACAGGC	0.338													37	96					0	0	0	0	A	30380094	A	A	30380094	3	1	57	1	0	0	0	0	1	0	0	0	13821	1783	62	5	254	5	RWDD2B	21	30380094	Missense_Mutation	SNP	T	TCGA-CN-5359-01A-01D-1434-08	2083649	30380094	17749801	173	11382											
SEC14L3	266629	broad.mit.edu	37	chr22	30858091	30858091	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	accttggttaaacatttgggGttcccatctgggtcagtcag	8	13	11	9	0	3	0	2	0	1	0	4	0	4	0	2	4	1	2	2	4	2	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chr22:30858091G>C	uc003ahy.2	-	9	842	c.753C>G	c.(751-753)AAC>AAG	p.N251K	SEC14L3_uc003ahz.2_Missense_Mutation_p.N174K|SEC14L3_uc003aia.2_Missense_Mutation_p.N192K|SEC14L3_uc003aib.2_Missense_Mutation_p.N192K	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	251						integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	AACATTTGGGGTTCCCATCTG	0.473													8	37					0	0	0	0	C	30858091	C	C	30858091	3	2	57	1	0	0	0	0	1	0	0	0	14048	1252	44	4	465	4	SEC14L3	22	30858091	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08		30858091	20446475	174	11383											
P2RY10	27334	broad.mit.edu	37	chrX	78216634	78216634	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tacagttgctgagcttgcagGatttgtgatcccagtgatca	9	13	11	8	0	1	3	1	3	0	0	2	4	2	4	1	1	4	4	1	1	1	4			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chrX:78216634G>T	uc004ede.2	+	4	986	c.617G>T	c.(616-618)GGA>GTA	p.G206V	P2RY10_uc004edf.2_Missense_Mutation_p.G206V	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	206	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						GAGCTTGCAGGATTTGTGATC	0.458													10	56					3.07112e-06	3.5261e-06	1	0	T	78216634	T	T	78216634	3	4	57	1	0	0	0	0	1	0	0	0	11401	1174	41	2	619	2	P2RY10	23	78216634	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08		78216634	77053926	175	11384											
SLC10A3	8273	broad.mit.edu	37	chrX	153716765	153716765	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcaggcgtgtcttcagcaGgtgagaccttgatgcagaag	9	9	15	8	1	2	3	1	2	1	2	2	4	2	3	1	3	2	3	1	3	1	2			TCGA-CN-5359-01A-01D-1434-08	TCGA-CN-5359-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	dcf1e53d-22dc-4b11-9b3f-e421bc28b835	0aa9f9d9-40fb-4ab2-add5-68931d6367eb	g.chrX:153716765G>A	uc004flq.2	-	3	779	c.515C>T	c.(514-516)CCT>CTT	p.P172L	UBL4A_uc004flo.2_5'Flank|SLC10A3_uc004flr.2_Missense_Mutation_p.P143L|SLC10A3_uc004flp.2_Missense_Mutation_p.P172L	NM_001142392	NP_001135864	P09131	P3_HUMAN	solute carrier family 10, member 3 isoform 1	172					organic anion transport	integral to membrane	bile acid:sodium symporter activity			ovary(1)|skin(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTCTTCAGCAGGTGAGACCTT	0.602													53	67					0	0	0	0	A	153716765	A	A	153716765	3	1	57	1	0	0	0	0	1	0	0	0	14440	1000	35	4	922	4	SLC10A3	23	153716765	Missense_Mutation	SNP	G	TCGA-CN-5359-01A-01D-1434-08	75500131	153716765	1553795	176	11385											
GLTPD1	80772	broad.mit.edu	37	chr1	1263084	1263084	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggccctccccttcatccagCgtgtctacaacgtctcccag	7	9	7	18	2	3	0	1	0	2	0	6	0	5	0	5	1	3	0	5	1	2	2	rs145750452		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:1263084C>A	uc001aeo.2	+	3	1001	c.586C>A	c.(586-588)CGT>AGT	p.R196S		NM_001029885	NP_001025056	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	196						cytoplasm	glycolipid binding|glycolipid transporter activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CTTCATCCAGCGTGTCTACAA	0.672													21	64					1.64113e-05	1.78248e-05	1	0	A	1263084	A	A	1263084	3	1	58	1	0	0	0	0	1	0	0	0	6509	768	27	3	592	3	GLTPD1	1	1263084	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08		1263084	247987537	1	11386											
SPSB1	80176	broad.mit.edu	37	chr1	9416393	9416393	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgggacttggggcgcaaccGgctctaccacgatggcaaga	9	6	14	12	3	1	1	0	0	1	1	1	3	1	2	2	5	2	3	2	5	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:9416393G>T	uc010oae.1	+	2	782	c.443G>T	c.(442-444)CGG>CTG	p.R148L	SPSB1_uc001apv.2_Missense_Mutation_p.R148L	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	148	B30.2/SPRY.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		GGGCGCAACCGGCTCTACCAC	0.602													25	47					1.85244e-09	2.2527e-09	1	0	T	9416393	T	T	9416393	3	4	58	1	0	0	0	0	1	0	0	0	15178	1116	39	3	445	3	SPSB1	1	9416393	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	8153309	9416393	239834228	2	11387											
NPPB	4879	broad.mit.edu	37	chr1	11918861	11918861	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagaagagcaggagcaggagCgcccgggaaggtgctgtctg	11	4	18	8	2	1	2	0	0	1	2	1	5	1	5	1	4	4	3	1	4	3	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:11918861C>A	uc001atj.2	-	1	132	c.30G>T	c.(28-30)GCG>GCT	p.A10A		NM_002521	NP_002512	P16860	ANFB_HUMAN	natriuretic peptide precursor B preproprotein	10					body fluid secretion|cGMP biosynthetic process|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation	extracellular space	diuretic hormone activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)	Carvedilol(DB01136)|Nesiritide(DB04899)|Testosterone(DB00624)	GGAGCAGGAGCGCCCGGGAAG	0.527													37	60					2.40579e-17	3.3504e-17	1	0	A	11918861	A	A	11918861	2	1	58	1	0	0	0	0	0	0	0	1	10646	755	27	3		3	NPPB	1	11918861	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2502468	11918861	237331760	3	11388											
PRAMEF11	440560	broad.mit.edu	37	chr1	12884844	12884844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggtcataaaatgacctgtCgccatggtcagggcagttgt	10	10	12	9	1	2	1	2	1	0	0	3	1	2	1	2	3	0	2	2	3	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:12884844C>T	uc001auk.2	-	4	1463	c.1267G>A	c.(1267-1269)GAC>AAC	p.D423N		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	423											0						AATGACCTGTCGCCATGGTCA	0.468													6	211					0	0	0	0	T	12884844	T	T	12884844	3	4	58	1	0	0	0	0	1	0	0	0	12487	884	31	1	47	1	PRAMEF11	1	12884844	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	965983	12884844	236365777	4	11389											
IGSF21	84966	broad.mit.edu	37	chr1	18692115	18692115	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tggaccctcaacccacagatCgacaacgaggccctcttcag	11	6	8	16	2	3	1	2	0	1	1	4	4	3	2	3	2	2	0	3	2	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:18692115C>G	uc001bau.1	+	6	1322	c.939C>G	c.(937-939)ATC>ATG	p.I313M	IGSF21_uc001bav.1_Missense_Mutation_p.I134M	NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	313						extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		ACCCACAGATCGACAACGAGG	0.642													23	57					0	0	0	0	G	18692115	G	G	18692115	3	3	58	1	0	0	0	0	1	0	0	0	7638	874	31	3	961	3	IGSF21	1	18692115	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5807271	18692115	230558506	5	11390											
SMPDL3B	27293	broad.mit.edu	37	chr1	28285042	28285042	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaatgctcaggggacgccgcGctgggagctcgagtaccagc	8	5	16	12	4	1	0	1	0	0	0	2	4	1	2	2	3	4	4	2	3	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:28285042G>T	uc001bpg.2	+	8	1252	c.1061G>T	c.(1060-1062)CGC>CTC	p.R354L	SMPDL3B_uc010ofq.1_Missense_Mutation_p.R148L|SMPDL3B_uc010ofr.1_Missense_Mutation_p.R306L|XKR8_uc001bph.1_5'Flank	NM_014474	NP_055289	Q92485	ASM3B_HUMAN	acid sphingomyelinase-like phosphodiesterase 3B	354					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			ovary(3)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		GGGACGCCGCGCTGGGAGCTC	0.632													27	43					2.08973e-25	3.227e-25	1	0	T	28285042	T	T	28285042	3	4	58	1	0	0	0	0	1	0	0	0	14873	1087	38	3	1208	3	SMPDL3B	1	28285042	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	9592927	28285042	220965579	6	11391											
CD53	963	broad.mit.edu	37	chr1	111435056	111435056	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cataacctcccctccctcacGctgggcaatgtgtttgtcat	7	12	7	15	1	2	0	2	0	0	0	4	0	4	0	4	1	1	3	4	1	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:111435056G>T	uc001dzw.2	+	4	324	c.153G>T	c.(151-153)ACG>ACT	p.T51T	CD53_uc001dzx.2_Silent_p.T51T|CD53_uc010owa.1_Silent_p.T51T|CD53_uc001dzy.2_Silent_p.T51T	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	51	Extracellular (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		CCTCCCTCACGCTGGGCAATG	0.507													39	105					2.75727e-19	3.96977e-19	1	0	T	111435056	T	T	111435056	2	4	58	1	0	0	0	0	0	0	0	1	3038	1074	38	3		3	CD53	1	111435056	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	83150014	111435056	137815565	7	11392											
NBPF10	100132406	broad.mit.edu	37	chr1	145296541	145296541	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggctgaggggtgtagactgGcacagcaccttgtccaaaag	10	8	14	9	0	0	2	0	1	0	1	1	2	1	2	2	4	1	4	2	4	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:145296541G>C	uc001end.3	+	3	498	c.463G>C	c.(463-465)GCA>CCA	p.A155P	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.A155P|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	155											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GTGTAGACTGGCACAGCACCT	0.577													44	331					0	0	0	0	C	145296541	C	C	145296541	3	2	58	1	0	0	0	0	1	0	0	0	10246	1203	42	4	473	4	NBPF10	1	145296541	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	33861485	145296541	103954080	8	11393											
NBPF10	100132406	broad.mit.edu	37	chr1	145368536	145368536	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaatgtactttgaactacCtgactcattccagcactaca	12	12	5	12	0	2	2	2	2	0	0	3	2	3	2	2	0	5	2	2	0	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:145368536C>G	uc001end.3	+	86	10774	c.10739C>G	c.(10738-10740)CCT>CGT	p.P3580R	NBPF9_uc010oye.1_Missense_Mutation_p.P864R|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Missense_Mutation_p.P433R|NBPF10_uc010oyk.1_Missense_Mutation_p.P221R|NBPF10_uc010oyl.1_Missense_Mutation_p.P221R	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3505											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTTGAACTACCTGACTCATTC	0.458													15	492					0	0	0	0	G	145368536	G	G	145368536	3	3	58	1	0	0	0	0	1	0	0	0	10246	681	24	4	10848	4	NBPF10	1	145368536	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	71995	145368536	103882085	9	11394											
HIST2H2BF	440689	broad.mit.edu	37	chr1	149783631	149783631	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtggagcgcttgttgtagTgcgccaggcgggacgcctct	4	10	17	10	4	1	0	0	0	1	0	1	2	1	2	2	4	2	3	2	4	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:149783631T>A	uc001esr.2	-	1	298	c.248A>T	c.(247-249)CAC>CTC	p.H83L	HIST2H2BF_uc010pbj.1_Missense_Mutation_p.H83L|HIST2H2BF_uc010pbk.1_Missense_Mutation_p.H83L	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	83					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					CTTGTTGTAGTGCGCCAGGCG	0.667													37	89					0	0	0	0	A	149783631	A	A	149783631	3	1	58	1	0	0	0	0	1	0	0	0	7219	1696	59	5	553	5	HIST2H2BF	1	149783631	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	4415095	149783631	99466990	10	11395											
PLEKHO1	51177	broad.mit.edu	37	chr1	150131289	150131289	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgacgcccacagagaaaggCcgctgcgcctccctggagga	9	5	13	14	3	0	2	0	1	0	1	1	5	1	4	4	3	1	1	4	3	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:150131289C>A	uc001ett.2	+	6	1079	c.801C>A	c.(799-801)GGC>GGA	p.G267G	PLEKHO1_uc001etr.2_Silent_p.G95G|PLEKHO1_uc001ets.2_Silent_p.G84G|PLEKHO1_uc001etu.2_Silent_p.G95G	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	267	Interaction with ATM, CKIP, IFP35 and NMI.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGAGAAAGGCCGCTGCGCCT	0.647													20	46					1.64113e-05	1.78248e-05	1	0	A	150131289	A	A	150131289	2	1	58	1	0	0	0	0	0	0	0	1	12139	726	26	4		4	PLEKHO1	1	150131289	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	347658	150131289	99119332	11	11396											
HORMAD1	84072	broad.mit.edu	37	chr1	150689696	150689696	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gatactgaaactgctagaagCctcttcactaacaccaaaga	16	8	6	11	0	2	3	1	1	1	2	2	4	2	3	2	0	5	1	2	0	6	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:150689696C>A	uc001evk.1	-	3	202	c.96G>T	c.(94-96)AGG>AGT	p.R32S	HORMAD1_uc001evl.1_Missense_Mutation_p.R32S|HORMAD1_uc001evm.1_5'UTR	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	32	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			CTGCTAGAAGCCTCTTCACTA	0.348													43	146					7.70917e-36	1.24702e-35	1	0	A	150689696	A	A	150689696	3	1	58	1	0	0	0	0	1	0	0	0	7325	738	26	4	1140	4	HORMAD1	1	150689696	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	558407	150689696	98560925	12	11397											
CTSS	1520	broad.mit.edu	37	chr1	150724474	150724474	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cactgaaagcccagcaagcaCcacaagaaccctaaaacaga	19	2	6	14	0	0	3	0	1	0	2	0	3	0	3	3	0	5	2	3	0	6	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:150724474C>A	uc001evn.2	-	5	543	c.410G>T	c.(409-411)GGT>GTT	p.G137V	CTSS_uc010pcj.1_Missense_Mutation_p.G87V|CTSS_uc001evo.1_Missense_Mutation_p.G137V	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	137					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			CCAGCAAGCACCACAAGAACC	0.498													21	66					3.62473e-10	4.49625e-10	1	0	A	150724474	A	A	150724474	3	1	58	1	0	0	0	0	1	0	0	0	4058	507	18	4	601	4	CTSS	1	150724474	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	34778	150724474	98526147	13	11398											
FCRL4	83417	broad.mit.edu	37	chr1	157557067	157557067	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggctctccaacactcacgCtgcacatggatctgtagcga	9	9	9	14	2	3	0	1	0	2	0	4	2	3	1	1	2	3	4	1	2	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:157557067C>A	uc001fqw.2	-	5	982	c.846G>T	c.(844-846)CAG>CAT	p.Q282H	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	282	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				AACACTCACGCTGCACATGGA	0.532													67	227					1.31726e-23	1.9979e-23	1	0	A	157557067	A	A	157557067	3	1	58	1	0	0	0	0	1	0	0	0	5829	811	28	4	733	4	FCRL4	1	157557067	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	6832593	157557067	91693554	14	11399											
FCRL2	79368	broad.mit.edu	37	chr1	157739772	157739772	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggcagaaatctggagctccGgagagctgctccagcctgac	9	6	13	13	2	1	3	0	1	1	2	3	5	3	4	3	3	4	4	3	3	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:157739772G>A	uc001fre.2	-	4	538	c.479C>T	c.(478-480)CCG>CTG	p.P160L	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.P160L|FCRL2_uc009wsp.2_Intron|FCRL2_uc010pia.1_Missense_Mutation_p.P160L	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	160	Extracellular (Potential).|Ig-like C2-type 2.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTGGAGCTCCGGAGAGCTGCT	0.537													25	86					0	0	0	0	A	157739772	A	A	157739772	3	1	58	1	0	0	0	0	1	0	0	0	5827	1116	39	1	1083	1	FCRL2	1	157739772	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	182705	157739772	91510849	15	11400											
FCRL1	115350	broad.mit.edu	37	chr1	157773822	157773822	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaactgggcatctgaactCtgtagaaagggcatcttaca	12	10	11	8	0	3	2	0	1	3	1	3	3	3	3	0	3	3	3	0	3	5	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:157773822C>A	uc001frg.2	-	3	245	c.132G>T	c.(130-132)CAG>CAT	p.Q44H	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Missense_Mutation_p.Q44H|FCRL1_uc001fri.2_Missense_Mutation_p.Q44H|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	44	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CATCTGAACTCTGTAGAAAGG	0.562													38	149					2.32173e-10	2.9011e-10	1	0	A	157773822	A	A	157773822	3	1	58	1	0	0	0	0	1	0	0	0	5826	912	32	2	1259	2	FCRL1	1	157773822	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	34050	157773822	91476799	16	11401											
SPTA1	6708	broad.mit.edu	37	chr1	158636152	158636152	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggccgtgtttcctgagtCgattctgtacctcggccagg	5	11	14	11	3	1	1	0	1	1	0	4	3	2	2	4	4	1	2	4	4	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:158636152C>A	uc001fst.1	-	16	2373	c.2174G>T	c.(2173-2175)CGA>CTA	p.R725L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	725	Spectrin 8.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTTCCTGAGTCGATTCTGTAC	0.517													10	41					2.27111e-07	2.58201e-07	1	0	A	158636152	A	A	158636152	3	1	58	1	0	0	0	0	1	0	0	0	15182	884	31	3	5233	3	SPTA1	1	158636152	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	862330	158636152	90614469	17	11402											
MNDA	4332	broad.mit.edu	37	chr1	158815619	158815619	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcattaccatatctgattaCtctgaatgtaaaggagtaat	14	14	7	6	0	3	2	1	2	2	0	3	3	3	3	1	1	2	2	1	1	7	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:158815619C>A	uc001fsz.1	+	5	1013	c.813C>A	c.(811-813)TAC>TAA	p.Y271*		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	271	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TATCTGATTACTCTGAATGTA	0.343													13	67					1.49906e-05	1.63337e-05	1	0	A	158815619	A	A	158815619	4	1	58	1	0	0	0	0	0	1	0	0	9729	576	20	4	827	4	MNDA	1	158815619	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	179467	158815619	90435002	18	11403											
DUSP27	92235	broad.mit.edu	37	chr1	167096649	167096649	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaaggcagtaccagcggctAgctgcctgggggatgaccaa	10	6	15	10	1	0	2	0	2	0	0	0	3	0	3	3	4	4	4	3	4	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:167096649A>G	uc001geb.1	+	5	2281	c.2281A>G	c.(2281-2283)AGC>GGC	p.S761G		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	761					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						ACCAGCGGCTAGCTGCCTGGG	0.562													16	73					0	0	0	0	G	167096649	G	G	167096649	3	3	58	1	0	0	0	0	1	0	0	0	4846	420	15	5	2299	5	DUSP27	1	167096649	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	8281030	167096649	82153972	19	11404											
F5	2153	broad.mit.edu	37	chr1	169526028	169526028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggacctggccgttgaaatGaatggagaataattctggcc	12	9	12	8	1	1	3	0	2	1	1	1	5	1	4	3	4	0	1	3	4	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:169526028G>A	uc001ggg.1	-	6	953	c.808C>T	c.(808-810)CAT>TAT	p.H270Y	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	270	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCGTTGAAATGAATGGAGAAT	0.507													16	64					0	0	0	0	A	169526028	A	A	169526028	3	1	58	1	0	0	0	0	1	0	0	0	5373	1290	45	2	5946	2	F5	1	169526028	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2429379	169526028	79724593	20	11405											
C1orf129	80133	broad.mit.edu	37	chr1	170927641	170927641	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tattggatgcatactcaggcCtgttaagtaatgaatccatg	12	13	9	7	0	1	1	1	1	0	0	2	2	2	2	2	2	2	3	2	2	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:170927641C>A	uc001ghg.2	+	4	242	c.112C>A	c.(112-114)CTG>ATG	p.L38M	C1orf129_uc009wvy.2_Translation_Start_Site|C1orf129_uc010plz.1_Missense_Mutation_p.L38M	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	38							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATACTCAGGCCTGTTAAGTAA	0.333													30	142					7.6516e-34	1.23185e-33	1	0	A	170927641	A	A	170927641	3	1	58	1	0	0	0	0	1	0	0	0	2005	680	24	4	122	4	C1orf129	1	170927641	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1401613	170927641	78322980	21	11406											
TNR	7143	broad.mit.edu	37	chr1	175348704	175348704	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacctgtcagggtggccctGgtggttggaccaatgcccct	5	10	13	13	0	2	0	2	0	0	0	2	1	2	1	5	5	1	1	5	5	1	1	rs140708810		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:175348704G>A	uc001gkp.1	-	7	2028	c.1947C>T	c.(1945-1947)ACC>ACT	p.T649T	TNR_uc009wwu.1_Silent_p.T649T	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	649	Fibronectin type-III 4.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GGGTGGCCCTGGTGGTTGGAC	0.532													19	68					0	0	0	0	A	175348704	A	A	175348704	2	1	58	1	0	0	0	0	0	0	0	1	16404	1335	47	4		4	TNR	1	175348704	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	4421063	175348704	73901917	22	11407											
PAPPA2	60676	broad.mit.edu	37	chr1	176526124	176526124	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcttcacatttccaaccttgGcccaagcattcccttaaaca	11	12	3	15	0	2	0	1	0	1	0	4	0	4	0	4	1	3	1	4	1	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:176526124G>T	uc001gkz.2	+	2	1830	c.666G>T	c.(664-666)TGG>TGT	p.W222C	PAPPA2_uc001gky.1_Missense_Mutation_p.W222C|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	222					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TCCAACCTTGGCCCAAGCATT	0.562													35	110					1.99505e-19	2.90306e-19	1	0	T	176526124	T	T	176526124	3	4	58	1	0	0	0	0	1	0	0	0	11487	1212	42	4	668	4	PAPPA2	1	176526124	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1177420	176526124	72724497	23	11408											
ASTN1	460	broad.mit.edu	37	chr1	176927497	176927497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcacctgacctccacagcatCctccatcacagtcatgtccg	9	9	5	18	1	3	1	3	1	0	0	7	1	7	1	6	0	1	1	6	0	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:176927497C>T	uc001glc.2	-	10	1932	c.1720G>A	c.(1720-1722)GAT>AAT	p.D574N	ASTN1_uc001glb.1_Missense_Mutation_p.D574N|ASTN1_uc001gld.1_Missense_Mutation_p.D574N|ASTN1_uc009wwx.1_Missense_Mutation_p.D574N	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	582					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCCACAGCATCCTCCATCACA	0.532													13	49					0	0	0	0	T	176927497	T	T	176927497	3	4	58	1	0	0	0	0	1	0	0	0	1066	855	30	2	2224	2	ASTN1	1	176927497	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	401373	176927497	72323124	24	11409											
TDRD5	163589	broad.mit.edu	37	chr1	179587802	179587802	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actatcagttcagaactaaaAcataagataaaatttgtaag	20	11	5	5	0	2	2	2	0	0	2	2	2	2	2	0	0	2	2	0	0	8	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:179587802A>G	uc001gnf.1	+	5	1150	c.900A>G	c.(898-900)AAA>AAG	p.K300K	TDRD5_uc010pnp.1_Silent_p.K300K|TDRD5_uc001gnh.1_5'UTR	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	300	Lotus/OST-HTH 3.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CAGAACTAAAACATAAGATAA	0.289													31	89					0	0	0	0	G	179587802	G	G	179587802	2	3	58	1	0	0	0	0	0	0	0	1	15799	40	2	5		5	TDRD5	1	179587802	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	2660305	179587802	69662819	25	11410											
CACNA1E	777	broad.mit.edu	37	chr1	181690998	181690998	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctacttcattgtgctcacCttgtttggcaactgtatcct	7	17	6	11	0	3	0	2	0	1	0	4	0	4	0	2	1	3	4	2	1	3	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:181690998C>A	uc001gow.2	+	16	2226	c.2061C>A	c.(2059-2061)ACC>ACA	p.T687T	CACNA1E_uc009wxs.2_Silent_p.T594T	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	687	Helical; Name=S6 of repeat II.|II.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TTGTGCTCACCTTGTTTGGCA	0.537													41	139					2.26627e-22	3.3845e-22	1	0	A	181690998	A	A	181690998	2	1	58	1	0	0	0	0	0	0	0	1	2554	668	24	4		4	CACNA1E	1	181690998	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2103196	181690998	67559623	26	11411											
CACNA1E	777	broad.mit.edu	37	chr1	181731752	181731752	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatctttgacttcatcaccGtgattggcagtatcacagaa	12	13	7	9	1	4	3	3	2	1	1	4	3	4	3	1	1	0	2	1	1	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:181731752G>A	uc001gow.2	+	33	4813	c.4648G>A	c.(4648-4650)GTG>ATG	p.V1550M	CACNA1E_uc009wxs.2_Missense_Mutation_p.V1438M|CACNA1E_uc001gox.1_Missense_Mutation_p.V776M|CACNA1E_uc009wxt.2_Missense_Mutation_p.V776M	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1550	Helical; Name=S3 of repeat IV.|IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CTTCATCACCGTGATTGGCAG	0.388													10	26					0	0	0	0	A	181731752	A	A	181731752	3	1	58	1	0	0	0	0	1	0	0	0	2554	1145	40	1	4778	1	CACNA1E	1	181731752	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	40754	181731752	67518869	27	11412											
CFHR4	10877	broad.mit.edu	37	chr1	196871597	196871597	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caacatggaggtctatattaTaagagtttgcgtagactata	14	13	9	5	1	1	2	0	0	1	2	1	3	1	3	0	2	2	2	0	2	8	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:196871597T>C	uc001gto.2	+	2	177	c.108T>C	c.(106-108)TAT>TAC	p.Y36Y	CFHR4_uc009wyy.2_Silent_p.Y35Y|CFHR4_uc001gtp.2_Silent_p.Y36Y	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	36	Sushi 1.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						GTCTATATTATAAGAGTTTGC	0.318													71	176					0	0	0	0	C	196871597	C	C	196871597	2	2	58	1	0	0	0	0	0	0	0	1	3302	1413	49	5		5	CFHR4	1	196871597	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	15139845	196871597	52379024	28	11413											
PTPRC	5788	broad.mit.edu	37	chr1	198701448	198701448	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagcatcccgcgggtgttcaGcaagtttcctataaaggaag	11	9	12	9	2	1	0	1	0	0	0	3	2	3	1	2	2	2	4	2	2	5	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:198701448G>T	uc001gur.1	+	19	2168	c.1988G>T	c.(1987-1989)AGC>ATC	p.S663I	PTPRC_uc001gus.1_Missense_Mutation_p.S615I|PTPRC_uc001gut.1_Missense_Mutation_p.S502I|PTPRC_uc009wzf.1_Missense_Mutation_p.S551I|PTPRC_uc010ppg.1_Missense_Mutation_p.S599I	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	663	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CGGGTGTTCAGCAAGTTTCCT	0.398													19	83					3.5997e-14	4.8161e-14	1	0	T	198701448	T	T	198701448	3	4	58	1	0	0	0	0	1	0	0	0	12862	971	34	4	2069	4	PTPRC	1	198701448	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1829851	198701448	50549173	29	11414											
NR5A2	2494	broad.mit.edu	37	chr1	200017865	200017865	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaaaagctgagcacctttggGcttatgtgcaaaatggcaga	13	9	12	7	0	0	2	0	1	0	1	0	3	0	2	1	2	3	5	1	2	5	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:200017865G>T	uc001gvb.2	+	5	1235	c.1029G>T	c.(1027-1029)GGG>GGT	p.G343G	NR5A2_uc001gvc.2_Silent_p.G297G|NR5A2_uc009wzh.2_Silent_p.G303G|NR5A2_uc010pph.1_Silent_p.G271G	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	343	Ligand-binding.				embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					GCACCTTTGGGCTTATGTGCA	0.478													42	137					4.14194e-30	6.54445e-30	1	0	T	200017865	T	T	200017865	2	4	58	1	0	0	0	0	0	0	0	1	10690	1190	42	4		4	NR5A2	1	200017865	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1316417	200017865	49232756	30	11415											
MYOG	4656	broad.mit.edu	37	chr1	203054660	203054660	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccccggtagcggaggtcacGctcctcctggttgagggagc	5	7	16	13	3	1	1	1	1	0	0	3	3	3	3	4	5	2	3	4	5	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:203054660G>C	uc001gzd.2	-	1	718	c.430C>G	c.(430-432)CGT>GGT	p.R144G		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	144					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2						CGGAGGTCACGCTCCTCCTGG	0.701													15	41					0	0	0	0	C	203054660	C	C	203054660	3	2	58	1	0	0	0	0	1	0	0	0	10143	1087	38	3	256	3	MYOG	1	203054660	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3036795	203054660	46195961	31	11416											
PLXNA2	5362	broad.mit.edu	37	chr1	208390886	208390886	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggtagaggctcccacaggCcagcaggcggttctcagagt	8	7	14	12	1	1	2	1	0	1	2	3	2	2	2	2	5	1	4	2	5	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:208390886C>T	uc001hgz.2	-	2	1140	c.382G>A	c.(382-384)GCC>ACC	p.A128T	PLXNA2_uc001hha.3_Missense_Mutation_p.A182T	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	128	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CTCCCACAGGCCAGCAGGCGG	0.587													34	133					0	0	0	0	T	208390886	T	T	208390886	3	4	58	1	0	0	0	0	1	0	0	0	12175	739	26	4	5426	4	PLXNA2	1	208390886	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5336226	208390886	40859735	32	11417											
USH2A	7399	broad.mit.edu	37	chr1	216373030	216373030	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagaactgattttctgcatCttaggtggacttagtctttg	8	17	10	6	0	3	2	0	1	3	1	3	3	3	3	0	2	2	2	0	2	4	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:216373030C>T	uc001hku.1	-	17	4137	c.3750G>A	c.(3748-3750)AAG>AAA	p.K1250K	USH2A_uc001hkv.2_Silent_p.K1250K	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1250	Fibronectin type-III 3.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTTTCTGCATCTTAGGTGGAC	0.478										HNSCC(13;0.011)			21	80					0	0	0	0	T	216373030	T	T	216373030	2	4	58	1	0	0	0	0	0	0	0	1	17104	912	32	2		2	USH2A	1	216373030	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	7982144	216373030	32877591	33	11418											
KCNK1	3775	broad.mit.edu	37	chr1	233802661	233802661	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttatttccctgagcaccAttggcctgggggattatgtg	6	15	12	8	0	0	1	0	1	0	0	1	2	1	2	3	3	1	2	3	3	2	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:233802661A>G	uc010pxo.1	+	2	844	c.676A>G	c.(676-678)ATT>GTT	p.I226V	KCNK1_uc001hvw.2_RNA|KCNK1_uc001hvx.2_RNA	NM_002245	NP_002236	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	226						voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	CCTGAGCACCATTGGCCTGGG	0.483													35	115					0	0	0	0	G	233802661	G	G	233802661	3	3	58	1	0	0	0	0	1	0	0	0	8097	217	8	5	682	5	KCNK1	1	233802661	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	17429631	233802661	15447960	34	11419											
RGS7	6000	broad.mit.edu	37	chr1	241094032	241094032	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgaccataatctgtgttttCcggctcccaacaatttgatg	9	14	7	11	1	1	2	0	2	1	0	3	2	3	2	3	1	1	2	3	1	3	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:241094032C>A	uc001hyv.2	-	6	700	c.370G>T	c.(370-372)GAA>TAA	p.E124*	RGS7_uc010pyh.1_Nonsense_Mutation_p.E98*|RGS7_uc010pyj.1_Nonsense_Mutation_p.E40*|RGS7_uc001hyu.2_Nonsense_Mutation_p.E124*|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Nonsense_Mutation_p.E124*	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	124					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCTGTGTTTTCCGGCTCCCAA	0.383													72	222					4.49761e-31	7.17301e-31	1	0	A	241094032	A	A	241094032	4	1	58	1	0	0	0	0	0	1	0	0	13375	864	30	2	1145	2	RGS7	1	241094032	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	7291371	241094032	8156589	35	11420											
MAP1LC3C	440738	broad.mit.edu	37	chr1	242159636	242159636	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcatgctgaccaggctcttGttgttcaccagcaagtaaaa	11	11	8	11	0	3	1	2	1	1	0	3	1	3	1	2	1	2	6	2	1	3	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:242159636G>A	uc001hzk.2	-	4	348	c.273C>T	c.(271-273)AAC>AAT	p.N91N		NM_001004343	NP_001004343	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3	91					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CCAGGCTCTTGTTGTTCACCA	0.572													41	127					0	0	0	0	A	242159636	A	A	242159636	2	1	58	1	0	0	0	0	0	0	0	1	9286	1368	48	4		4	MAP1LC3C	1	242159636	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1065604	242159636	7090985	36	11421											
PLD5	200150	broad.mit.edu	37	chr1	242511469	242511469	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctctcccatgatgtccaCggctgaaaagatcagtgcaa	12	9	8	12	1	2	3	1	2	1	1	5	3	4	3	3	1	1	2	3	1	3	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:242511469C>A	uc001hzn.1	-	2	392	c.265G>T	c.(265-267)GTG>TTG	p.V89L	PLD5_uc001hzl.3_Missense_Mutation_p.V27L|PLD5_uc001hzm.3_5'UTR|PLD5_uc001hzo.1_5'UTR			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	89	Helical; (Potential).					integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			ATGATGTCCACGGCTGAAAAG	0.448													35	128					6.97489e-18	9.7936e-18	1	0	A	242511469	A	A	242511469	3	1	58	1	0	0	0	0	1	0	0	0	12104	551	19	3		3	PLD5	1	242511469	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	351833	242511469	6739152	37	11422											
CEP170	9859	broad.mit.edu	37	chr1	243349671	243349671	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcacgtttgctacagcgccTgtgagccccagcgttctctg	5	11	11	14	3	1	1	0	1	1	0	2	1	1	1	3	0	6	4	3	0	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:243349671T>A	uc001hzs.2	-	9	1570	c.1162A>T	c.(1162-1164)AGG>TGG	p.R388W	CEP170_uc001hzt.2_Missense_Mutation_p.R388W|CEP170_uc001hzu.2_Missense_Mutation_p.R388W	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	388						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CTACAGCGCCTGTGAGCCCCA	0.438													59	177					0	0	0	0	A	243349671	A	A	243349671	3	1	58	1	0	0	0	0	1	0	0	0	3265	1579	55	5	3670	5	CEP170	1	243349671	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	838202	243349671	5900950	38	11423											
KIF26B	55083	broad.mit.edu	37	chr1	245850938	245850938	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccggcaggaggagccggaCagcctctcctattactgcgc	8	6	13	14	3	1	0	0	0	1	0	2	3	1	3	4	4	5	1	4	4	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:245850938C>G	uc001ibf.1	+	12	5093	c.4653C>G	c.(4651-4653)GAC>GAG	p.D1551E	KIF26B_uc001ibg.1_Missense_Mutation_p.D1169E|KIF26B_uc001ibh.1_Missense_Mutation_p.D793E	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1551					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGGAGCCGGACAGCCTCTCCT	0.662													3	7					0	0	0	0	G	245850938	G	G	245850938	3	3	58	1	0	0	0	0	1	0	0	0	8334	477	17	4	4699	4	KIF26B	1	245850938	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2501267	245850938	3399683	39	11424											
OR2C3	81472	broad.mit.edu	37	chr1	247695329	247695329	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggtaggagcatggtgagcGtggagcccaccatgctggtg	7	7	18	9	2	0	1	0	1	0	0	0	3	0	3	2	5	4	3	2	5	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:247695329G>T	uc009xgy.2	-	2	847	c.485C>A	c.(484-486)ACG>AAG	p.T162K	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CATGGTGAGCGTGGAGCCCAC	0.557													4	24					1.024e-07	1.17994e-07	1	0	T	247695329	T	T	247695329	3	4	58	1	0	0	0	0	1	0	0	0	11047	1145	40	3	481	3	OR2C3	1	247695329	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1844391	247695329	1555292	40	11425											
OR2M5	127059	broad.mit.edu	37	chr1	248308673	248308673	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catggacctcatgctcatctGctctaccgtacccaagatgg	9	10	8	14	1	4	1	2	0	2	1	4	2	4	2	3	2	4	3	3	2	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:248308673G>T	uc010pze.1	+	1	224	c.224G>T	c.(223-225)TGC>TTC	p.C75F		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			ATGCTCATCTGCTCTACCGTA	0.488													289	472					4.04438e-157	6.66882e-157	1	0	T	248308673	T	T	248308673	3	4	58	1	0	0	0	0	1	0	0	0	11067	1319	46	4	226	4	OR2M5	1	248308673	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	613344	248308673	941948	41	11426											
TPO	7173	broad.mit.edu	37	chr2	1459848	1459848	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aatggtctcttcctacccagGtccgggaggtgacaagacat	10	9	11	11	1	1	2	0	1	1	1	4	3	3	3	3	4	1	0	3	4	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:1459848G>T	uc002qww.2	+	7	704	c.613G>T	c.(613-615)GTC>TTC	p.V205F	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.V205F|TPO_uc002qwr.2_Missense_Mutation_p.V205F|TPO_uc002qwx.2_Missense_Mutation_p.V205F|TPO_uc010yio.1_Missense_Mutation_p.V205F|TPO_uc010yip.1_Missense_Mutation_p.V205F	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	205	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TCCTACCCAGGTCCGGGAGGT	0.493													7	30					0.00198382	0.00206572	1	0	T	1459848	T	T	1459848	3	4	58	1	0	0	0	0	1	0	0	0	16477	1275	44	4	635	4	TPO	2	1459848	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08		1459848	241739525	42	11427											
GREB1	9687	broad.mit.edu	37	chr2	11718542	11718542	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgaaccccagcatcctgatgGgagctcagcaggcaggtgag	10	5	14	12	1	1	2	1	2	0	0	2	4	2	3	3	3	4	4	3	3	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:11718542G>T	uc002rbk.1	+	6	1057	c.757G>T	c.(757-759)GGA>TGA	p.G253*	GREB1_uc002rbl.2_Nonsense_Mutation_p.G253*|GREB1_uc002rbm.2_Nonsense_Mutation_p.G143*|GREB1_uc002rbn.1_Nonsense_Mutation_p.G253*	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	253						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CATCCTGATGGGAGCTCAGCA	0.622													24	63					1.10513e-12	1.44452e-12	1	0	T	11718542	T	T	11718542	4	4	58	1	0	0	0	0	0	1	0	0	6799	1233	43	4	775	4	GREB1	2	11718542	Nonsense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	10258694	11718542	231480831	43	11428											
C2orf28	51374	broad.mit.edu	37	chr2	27438549	27438549	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaggaattaatgcctggaatActatcacctcttatatagac	14	12	7	8	0	2	1	1	0	1	1	2	4	2	3	2	2	2	0	2	2	8	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:27438549A>G	uc002rjf.2	+	5	753	c.580A>G	c.(580-582)ACT>GCT	p.T194A	C2orf28_uc002rjg.2_Missense_Mutation_p.T81A|C2orf28_uc002rjh.2_5'Flank|CAD_uc002rji.2_5'Flank|CAD_uc010eyw.2_5'Flank	NM_080592	NP_542159	Q6UW56	APR3_HUMAN	apoptosis related protein 3 isoform b	139	Extracellular (Potential).					integral to membrane|plasma membrane				skin(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCCTGGAATACTATCACCTC	0.423													55	137					0	0	0	0	G	27438549	G	G	27438549	3	3	58	1	0	0	0	0	1	0	0	0	2170	391	14	5	598	5	C2orf28	2	27438549	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	15720007	27438549	215760824	44	11429											
SLC30A3	7781	broad.mit.edu	37	chr2	27480193	27480193	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacccgtggctgtgggggggCccagcctggtgcagcacaaa	7	5	17	12	1	0	0	0	0	0	0	0	1	0	0	3	5	3	3	3	5	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:27480193C>G	uc002rjk.2	-	5	792	c.606G>C	c.(604-606)GGG>GGC	p.G202G	SLC30A3_uc002rjj.2_Missense_Mutation_p.G48A|SLC30A3_uc010ylh.1_Silent_p.G197G	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	202	Cytoplasmic (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTGGGGGGGCCCAGCCTGGT	0.662													8	17					0	0	0	0	G	27480193	G	G	27480193	2	3	58	1	0	0	0	0	0	0	0	1	14620	726	26	4		4	SLC30A3	2	27480193	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	41644	27480193	215719180	45	11430											
ABCG8	64241	broad.mit.edu	37	chr2	44079562	44079562	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgtgggcaacatgtacgtgCgggggttgtcggggggtgag	5	8	22	6	4	0	1	0	1	0	0	1	1	0	1	0	6	3	3	0	6	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:44079562C>T	uc002rtq.2	+	5	721	c.631C>T	c.(631-633)CGG>TGG	p.R211W	ABCG8_uc010yoa.1_Missense_Mutation_p.R211W	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	211	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CATGTACGTGCGGGGGTTGTC	0.667													19	44					0	0	0	0	T	44079562	T	T	44079562	3	4	58	1	0	0	0	0	1	0	0	0	72	759	27	1	649	1	ABCG8	2	44079562	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	16599369	44079562	199119811	46	11431											
SPTBN1	6711	broad.mit.edu	37	chr2	54753686	54753686	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggctttttgagcggtcccGcatcaaggctctggcaggtg	5	10	15	11	3	2	1	1	1	1	0	3	1	3	1	1	5	1	4	1	5	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:54753686G>T	uc002rxu.2	+	2	380	c.131G>T	c.(130-132)CGC>CTC	p.R44L	SPTBN1_uc002rxv.1_Missense_Mutation_p.R44L|RPL23AP32_uc010yot.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	44	Actin-binding.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GAGCGGTCCCGCATCAAGGCT	0.537													16	42					4.7546e-09	5.6805e-09	1	0	T	54753686	T	T	54753686	3	4	58	1	0	0	0	0	1	0	0	0	15185	1087	38	3	133	3	SPTBN1	2	54753686	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	10674124	54753686	188445687	47	11432											
CTNNA2	1496	broad.mit.edu	37	chr2	79971585	79971585	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaggtcaaagaaagcccatGtactagctgcctctgtagag	12	8	12	9	0	2	2	1	0	1	2	2	3	2	3	2	2	4	3	2	2	5	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:79971585G>T	uc010ysh.1	+	2	180	c.175G>T	c.(175-177)GTA>TTA	p.V59L	CTNNA2_uc010yse.1_Missense_Mutation_p.V59L|CTNNA2_uc010ysf.1_Missense_Mutation_p.V59L|CTNNA2_uc010ysg.1_Missense_Mutation_p.V59L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	59					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GAAAGCCCATGTACTAGCTGC	0.433													13	38					1.41608e-15	1.92485e-15	1	0	T	79971585	T	T	79971585	3	4	58	1	0	0	0	0	1	0	0	0	4030	1377	48	4	181	4	CTNNA2	2	79971585	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	25217899	79971585	163227788	48	11433											
CTNNA2	1496	broad.mit.edu	37	chr2	80831210	80831210	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtttcagaggcaaaggccCattgaaaaatacatctgatg	14	11	9	7	0	2	3	1	2	1	1	2	3	2	3	1	2	1	2	1	2	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:80831210C>A	uc010ysh.1	+	15	2206	c.2201C>A	c.(2200-2202)CCA>CAA	p.P734Q	CTNNA2_uc010yse.1_Missense_Mutation_p.P734Q|CTNNA2_uc010ysf.1_Missense_Mutation_p.P734Q|CTNNA2_uc010ysg.1_Missense_Mutation_p.P734Q|CTNNA2_uc010ysi.1_Missense_Mutation_p.P366Q|CTNNA2_uc010ysj.1_Missense_Mutation_p.P63Q	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	734					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GGCAAAGGCCCATTGAAAAAT	0.408													12	41					1.05317e-09	1.2946e-09	1	0	A	80831210	A	A	80831210	3	1	58	1	0	0	0	0	1	0	0	0	4030	594	21	4	2051	4	CTNNA2	2	80831210	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	859625	80831210	162368163	49	11434											
ZAP70	7535	broad.mit.edu	37	chr2	98340653	98340653	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctatgtgctgtcgctcgtgCacgatgtgcgcttccaccac	5	11	11	14	4	0	0	0	0	0	0	3	1	1	0	2	0	3	5	2	0	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:98340653C>T	uc002syd.1	+	3	361	c.154C>T	c.(154-156)CAC>TAC	p.H52Y	ZAP70_uc010yvf.1_Missense_Mutation_p.H52Y|ZAP70_uc002sye.1_5'Flank	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	52	SH2 1.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						GTCGCTCGTGCACGATGTGCG	0.677													8	8					0	0	0	0	T	98340653	T	T	98340653	3	4	58	1	0	0	0	0	1	0	0	0	17582	710	25	4	156	4	ZAP70	2	98340653	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	17509443	98340653	144858720	50	11435											
VWA3B	200403	broad.mit.edu	37	chr2	98851213	98851213	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgccagcagccggaggaCtgctctaagtgacaaaggca	13	5	12	11	1	1	1	0	1	1	0	1	3	1	3	2	3	4	3	2	3	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:98851213C>G	uc002syo.2	+	17	2675	c.2411C>G	c.(2410-2412)ACT>AGT	p.T804S	VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Missense_Mutation_p.T323S|VWA3B_uc002sym.2_Missense_Mutation_p.T804S|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.T461S|VWA3B_uc002syp.1_Missense_Mutation_p.T196S|VWA3B_uc002syq.1_Missense_Mutation_p.T80S|VWA3B_uc002syr.1_Missense_Mutation_p.T121S|VWA3B_uc010fih.1_5'Flank	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	804										ovary(3)|large_intestine(2)|skin(1)	6						AGCCGGAGGACTGCTCTAAGT	0.532													18	34					0	0	0	0	G	98851213	G	G	98851213	3	3	58	1	0	0	0	0	1	0	0	0	17309	565	20	4	2473	4	VWA3B	2	98851213	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	510560	98851213	144348160	51	11436											
NMS	129521	broad.mit.edu	37	chr2	101098739	101098739	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gttgctcctttttttttcagCccaggaatggaagaaacatt	10	15	8	8	0	1	1	1	0	0	1	2	3	2	3	2	2	3	2	2	2	3	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:101098739C>A	uc002tan.1	+	9	422	c.415C>A	c.(415-417)CCC>ACC	p.P139T		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	139					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						TTTTTTTCAGCCCAGGAATGG	0.423													15	90					1.3612e-06	1.51964e-06	1	0	A	101098739	A	A	101098739	3	1	58	1	0	0	0	0	1	0	0	0	10556	753	26	4	449	4	NMS	2	101098739	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2247526	101098739	142100634	52	11437											
IL1RL1	9173	broad.mit.edu	37	chr2	102955393	102955393	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggattggtattactcacaaaCaaacaaaagtattcccactc	16	10	5	10	0	1	0	1	0	0	0	3	1	2	1	1	2	3	2	1	2	7	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:102955393C>G	uc002tbu.1	+	3	429	c.158C>G	c.(157-159)ACA>AGA	p.T53R	IL1RL1_uc010ywa.1_Intron|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Missense_Mutation_p.T53R	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	53	Extracellular (Potential).|Ig-like C2-type 1.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TACTCACAAACAAACAAAAGT	0.418													54	231					0	0	0	0	G	102955393	G	G	102955393	3	3	58	1	0	0	0	0	1	0	0	0	7702	478	17	4	164	4	IL1RL1	2	102955393	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1856654	102955393	140243980	53	11438											
GPR45	11250	broad.mit.edu	37	chr2	105859167	105859167	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgctggctgccccactcCgtctacagcctcctgtctgt	3	12	8	18	1	3	0	0	0	3	0	5	0	5	0	5	1	4	2	5	1	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:105859167C>T	uc002tco.1	+	1	968	c.852C>T	c.(850-852)TCC>TCT	p.S284S		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	284	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TGCCCCACTCCGTCTACAGCC	0.587													75	220					0	0	0	0	T	105859167	T	T	105859167	2	4	58	1	0	0	0	0	0	0	0	1	6734	639	23	1		1	GPR45	2	105859167	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2903774	105859167	137340206	54	11439											
IL1F8	27177	broad.mit.edu	37	chr2	113788710	113788710	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcgagaatcacgaatagcAtaggatttgggtgctgcctc	10	11	12	8	2	1	1	1	0	0	1	3	4	1	2	1	2	3	2	1	2	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:113788710A>G	uc002tiq.1	-	3	140	c.36T>C	c.(34-36)TAT>TAC	p.Y12Y	IL1F8_uc002tir.1_Silent_p.Y12Y	NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	12					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						CACGAATAGCATAGGATTTGG	0.463													15	44					0	0	0	0	G	113788710	G	G	113788710	2	3	58	1	0	0	0	0	0	0	0	1	7695	224	8	5		5	IL1F8	2	113788710	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	7929543	113788710	129410663	55	11440											
CNTNAP5	129684	broad.mit.edu	37	chr2	125285021	125285021	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttacacattgatctgtgtaGcatcaaagacaggtaattat	14	14	7	6	0	2	2	1	1	1	1	2	2	2	2	0	1	2	3	0	1	5	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:125285021G>A	uc002tno.2	+	10	1998	c.1634G>A	c.(1633-1635)AGC>AAC	p.S545N	CNTNAP5_uc010flu.2_Missense_Mutation_p.S546N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	545	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GATCTGTGTAGCATCAAAGAC	0.398													38	120					0	0	0	0	A	125285021	A	A	125285021	3	1	58	1	0	0	0	0	1	0	0	0	3665	971	34	4	1672	4	CNTNAP5	2	125285021	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	11496311	125285021	117914352	56	11441											
GPR17	2840	broad.mit.edu	37	chr2	128408390	128408390	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcaatgtggccaggagacGccactggagaacatgctgtt	11	7	14	9	1	0	2	0	0	0	2	0	5	0	2	2	3	3	3	2	3	2	1	rs145234598		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:128408390G>A	uc010yzn.1	+	4	776	c.165G>A	c.(163-165)ACG>ACA	p.T55T	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Silent_p.T55T|GPR17_uc010yzo.1_Silent_p.T27T|GPR17_uc002tpd.2_Silent_p.T27T	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	55	Extracellular (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		gccaggagacgccactggaga	0.1											OREG0014966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	90					0	0	0	0	A	128408390	A	A	128408390	2	1	58	1	0	0	0	0	0	0	0	1	6705	1074	38	1		1	GPR17	2	128408390	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3123369	128408390	114790983	57	11442											
CCNT2	905	broad.mit.edu	37	chr2	135711427	135711427	+	Frame_Shift_Del	DEL	G	-	-																															tagaacagcagcacaaacaaGggcagtcacaggcagccagc																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:135711427delG	uc002tuc.1	+	9	1434	c.1402delG	c.(1402-1404)GGGfs	p.G468fs	CCNT2_uc002tub.1_Frame_Shift_Del_p.G468fs|CCNT2_uc010zbf.1_Frame_Shift_Del_p.G293fs|CCNT2_uc002tud.1_Frame_Shift_Del_p.G131fs	NM_058241	NP_490595	O60583	CCNT2_HUMAN	cyclin T2 isoform b	468					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein kinase binding			ovary(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.107)		GCACAAACAAGGGCAGTCACA	0.388													---	---	---								-	135711427	-	-	135711427	7	5	58	1	0	1	0	1	0	0	0	0	2950	1000	35	0	1436	0	CCNT2	2	135711427	Frame_Shift_Del	DEL	G	TCGA-CN-5360-01A-01D-1434-08	7303037	135711427	107487946	58	11443											
UBXN4	23190	broad.mit.edu	37	chr2	136499519	136499519	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gatgctgtggttccagggcgCcattccggccgccatcgcga	5	8	14	14	5	0	0	0	0	0	0	3	2	2	0	5	3	1	2	5	3	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:136499519C>G	uc002tur.2	+	1	331	c.20C>G	c.(19-21)GCC>GGC	p.A7G		NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	7	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						TTCCAGGGCGCCATTCCGGCC	0.701													7	23					0	0	0	0	G	136499519	G	G	136499519	3	3	58	1	0	0	0	0	1	0	0	0	16984	739	26	4	22	4	UBXN4	2	136499519	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	788092	136499519	106699854	59	11444											
LRP1B	53353	broad.mit.edu	37	chr2	141130602	141130602	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcacagcttttctcatcttcCccatatttgcagtcttcatg	7	17	4	13	0	5	0	3	0	3	0	7	0	6	0	2	0	2	2	2	0	1	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:141130602C>A	uc002tvj.1	-	69	11715	c.10743G>T	c.(10741-10743)GGG>GGT	p.G3581G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3581	Extracellular (Potential).|LDL-receptor class A 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTCATCTTCCCCATATTTGC	0.363										TSP Lung(27;0.18)			45	183					1.00221e-16	1.3788e-16	1	0	A	141130602	A	A	141130602	2	1	58	1	0	0	0	0	0	0	0	1	9005	610	22	4		4	LRP1B	2	141130602	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	4631083	141130602	102068771	60	11445											
LRP1B	53353	broad.mit.edu	37	chr2	141460116	141460116	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtccccattcagtccagaaCaagaggctgaaattaaattg	14	10	8	9	0	1	3	1	1	0	2	3	3	3	3	3	1	1	1	3	1	5	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:141460116C>A	uc002tvj.1	-	38	7002	c.6030G>T	c.(6028-6030)TTG>TTT	p.L2010F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2010	Extracellular (Potential).|LDL-receptor class B 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTCCAGAACAAGAGGCTGA	0.398										TSP Lung(27;0.18)			18	80					2.37509e-13	3.12851e-13	1	0	A	141460116	A	A	141460116	3	1	58	1	0	0	0	0	1	0	0	0	9005	477	17	4	7985	4	LRP1B	2	141460116	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	329514	141460116	101739257	61	11446											
MBD5	55777	broad.mit.edu	37	chr2	149226486	149226486	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactaatatggaaataccacGagcaatgttccaccacaaac	18	7	5	11	1	0	0	0	0	0	0	1	2	1	1	3	1	4	2	3	1	7	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:149226486G>T	uc002twm.3	+	9	1962	c.974G>T	c.(973-975)CGA>CTA	p.R325L	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.R325L|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	325						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GAAATACCACGAGCAATGTTC	0.433													23	59					2.89027e-11	3.69282e-11	1	0	T	149226486	T	T	149226486	3	4	58	1	0	0	0	0	1	0	0	0	9400	1058	37	3	988	3	MBD5	2	149226486	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	7766370	149226486	93972887	62	11447											
GALNT13	114805	broad.mit.edu	37	chr2	155102362	155102362	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatcattgatgtgattagtGatgatacttttgaatatatg	12	18	8	3	0	1	5	1	5	0	0	1	5	1	5	0	0	1	0	0	0	6	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:155102362G>T	uc002tyr.3	+	7	1291	c.724G>T	c.(724-726)GAT>TAT	p.D242Y	GALNT13_uc002tyt.3_Missense_Mutation_p.D242Y|GALNT13_uc010foc.1_Missense_Mutation_p.D61Y|GALNT13_uc010fod.2_5'UTR	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	242	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TGTGATTAGTGATGATACTTT	0.363													43	142					1.51926e-22	2.27387e-22	1	0	T	155102362	T	T	155102362	3	4	58	1	0	0	0	0	1	0	0	0	6246	1290	45	2	742	2	GALNT13	2	155102362	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5875876	155102362	88097011	63	11448											
GALNT13	114805	broad.mit.edu	37	chr2	155158090	155158090	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatttaaagatttcttctacAtcatatccccaggtacacaa	15	13	3	10	0	3	1	1	0	2	1	4	1	4	1	2	1	2	1	2	1	7	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:155158090A>T	uc002tyr.3	+	9	1711	c.1144A>T	c.(1144-1146)ATC>TTC	p.I382F	GALNT13_uc002tyt.3_Missense_Mutation_p.I382F|GALNT13_uc010foc.1_Missense_Mutation_p.I201F|GALNT13_uc010fod.2_Missense_Mutation_p.I135F	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	382	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TTTCTTCTACATCATATCCCC	0.353													40	136					0	0	0	0	T	155158090	T	T	155158090	3	4	58	1	0	0	0	0	1	0	0	0	6246	217	8	5	1170	5	GALNT13	2	155158090	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	55728	155158090	88041283	64	11449											
RBMS1	5937	broad.mit.edu	37	chr2	161223858	161223858	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgttattactgctggtggtGctgggactgggaggggccat	5	13	17	6	0	0	0	0	0	0	0	0	2	0	2	1	6	3	3	1	6	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:161223858G>A	uc002ubo.2	-	2	564	c.120C>T	c.(118-120)AGC>AGT	p.S40S	RBMS1_uc002ubj.2_Silent_p.S7S|RBMS1_uc002ubk.2_Silent_p.S7S|RBMS1_uc002ubl.2_Silent_p.S38S|RBMS1_uc002ubn.2_Silent_p.S40S|RBMS1_uc002ubi.3_Silent_p.S40S|RBMS1_uc002ubm.2_Silent_p.S7S|RBMS1_uc002ubp.2_Silent_p.S40S|RBMS1_uc010fox.2_Silent_p.S40S	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	40					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0						tgctggtggtgctgGGACTGG	0.433													31	74					0	0	0	0	A	161223858	A	A	161223858	2	1	58	1	0	0	0	0	0	0	0	1	13213	1310	46	4		4	RBMS1	2	161223858	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6065768	161223858	81975515	65	11450											
SCN3A	6328	broad.mit.edu	37	chr2	166019249	166019249	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagctgcagcccaatgagagCaaacacgctcagacagaaca	16	3	9	13	1	1	3	1	1	0	3	1	4	1	3	1	0	6	4	1	0	3	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:166019249C>T	uc002ucx.2	-	8	1276	c.784G>A	c.(784-786)GCT>ACT	p.A262T	SCN3A_uc002ucy.2_Missense_Mutation_p.A262T|SCN3A_uc002ucz.2_Missense_Mutation_p.A262T|SCN3A_uc002uda.1_Missense_Mutation_p.A131T|SCN3A_uc002udb.1_Missense_Mutation_p.A131T	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	262	Helical; Name=S5 of repeat I; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CCAATGAGAGCAAACACGCTC	0.483													34	98					0	0	0	0	T	166019249	T	T	166019249	3	4	58	1	0	0	0	0	1	0	0	0	13983	710	25	4	5302	4	SCN3A	2	166019249	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	4795391	166019249	77180124	66	11451											
SCN2A	6326	broad.mit.edu	37	chr2	166187857	166187857	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaacttgaagaatccagaCagaaatgcccaccatgctgg	15	6	9	11	0	0	5	0	1	0	4	1	5	1	5	3	1	3	1	3	1	4	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:166187857C>G	uc002udc.2	+	14	2457	c.2167C>G	c.(2167-2169)CAG>GAG	p.Q723E	SCN2A_uc002udd.2_Missense_Mutation_p.Q723E|SCN2A_uc002ude.2_Missense_Mutation_p.Q723E	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	723					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGAATCCAGACAGAAATGCCC	0.338													25	92					0	0	0	0	G	166187857	G	G	166187857	3	3	58	1	0	0	0	0	1	0	0	0	13981	479	17	4	2313	4	SCN2A	2	166187857	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	168608	166187857	77011516	67	11452											
GALNT3	2591	broad.mit.edu	37	chr2	166606398	166606398	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatgttgagcagagtattCaaagtactatggaaggaata	15	12	10	4	0	2	2	2	1	0	1	2	4	2	4	0	2	2	4	0	2	7	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:166606398C>T	uc010fph.1	-	10	2020	c.1633G>A	c.(1633-1635)GAA>AAA	p.E545K		NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	545	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						GCAGAGTATTCAAAGTACTAT	0.383													33	130					0	0	0	0	T	166606398	T	T	166606398	3	4	58	1	0	0	0	0	1	0	0	0	6249	835	29	2	276	2	GALNT3	2	166606398	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	418541	166606398	76592975	68	11453											
LRP2	4036	broad.mit.edu	37	chr2	170136935	170136935	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacccacggccactccacgAttctgagactccactaggat	11	7	7	16	2	1	1	0	1	1	1	3	4	3	2	4	2	0	0	4	2	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:170136935A>G	uc002ues.2	-	11	1479	c.1266T>C	c.(1264-1266)AAT>AAC	p.N422N	LRP2_uc010zdf.1_Silent_p.N422N	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	422	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCACTCCACGATTCTGAGACT	0.448													17	75					0	0	0	0	G	170136935	G	G	170136935	2	3	58	1	0	0	0	0	0	0	0	1	9006	330	12	5		5	LRP2	2	170136935	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	3530537	170136935	73062438	69	11454											
GPR155	151556	broad.mit.edu	37	chr2	175326175	175326175	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcaatgctatctccattGtgttttccagttatcaaaag	11	15	7	8	0	3	0	2	0	1	0	5	1	4	0	2	0	1	3	2	0	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:175326175G>A	uc002uit.2	-	10	1906	c.1515C>T	c.(1513-1515)CAC>CAT	p.H505H	GPR155_uc002uiu.2_Silent_p.H505H|GPR155_uc002uiv.2_Silent_p.H505H|GPR155_uc010fqs.2_Silent_p.H477H	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	505					intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						TATCTCCATTGTGTTTTCCAG	0.383													43	137					0	0	0	0	A	175326175	A	A	175326175	2	1	58	1	0	0	0	0	0	0	0	1	6698	1368	48	4		4	GPR155	2	175326175	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5189240	175326175	67873198	70	11455											
TTN	7273	broad.mit.edu	37	chr2	179437412	179437412	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacatttccaacaataagcaGggtgtaagagcttgtggatt	13	12	10	6	0	0	1	0	0	0	1	1	2	1	2	1	2	4	3	1	2	5	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179437412G>T	uc010zfg.1	-	275	65967	c.65743C>A	c.(65743-65745)CTG>ATG	p.L21915M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L15610M|TTN_uc010zfi.1_Missense_Mutation_p.L15543M|TTN_uc010zfj.1_Missense_Mutation_p.L15418M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22842							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAATAAGCAGGGTGTAAGAG	0.428													38	97					4.32679e-17	6.00111e-17	1	0	T	179437412	T	T	179437412	3	4	58	1	0	0	0	0	1	0	0	0	16803	991	35	4	34680	4	TTN	2	179437412	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	4111237	179437412	63761961	71	11456											
TTN	7273	broad.mit.edu	37	chr2	179476296	179476296	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggacacatttcaacatggTatcctatgataggacttcca	12	12	7	10	0	1	1	1	1	0	0	3	3	3	3	2	3	1	1	2	3	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179476296T>A	uc010zfg.1	-	218	43180	c.42956A>T	c.(42955-42957)TAC>TTC	p.Y14319F	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Y8014F|TTN_uc010zfi.1_Missense_Mutation_p.Y7947F|TTN_uc010zfj.1_Missense_Mutation_p.Y7822F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15246							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAACATGGTATCCTATGAT	0.438													41	135					0	0	0	0	A	179476296	A	A	179476296	3	1	58	1	0	0	0	0	1	0	0	0	16803	1638	57	5	57409	5	TTN	2	179476296	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	38884	179476296	63723077	72	11457											
TTN	7273	broad.mit.edu	37	chr2	179537416	179537416	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aacaggtactttttcctcagGaattttctttgacactttaa	11	17	5	8	0	2	1	1	1	1	0	3	2	3	2	1	2	2	1	1	2	4	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179537416G>T	uc010zfg.1	-	148	31122	c.30898C>A	c.(30898-30900)CCT>ACT	p.P10300T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6961T|TTN_uc010fre.1_Intron|TTN_uc010zfk.1_5'Flank|TTN_uc002una.1_RNA|TTN_uc010frf.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11227							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCCTCAGGAATTTTCTTT	0.373													6	24					1.06961e-07	1.22834e-07	1	0	T	179537416	T	T	179537416	3	4	58	1	0	0	0	0	1	0	0	0	16803	1174	41	2	69747	2	TTN	2	179537416	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	61120	179537416	63661957	73	11458											
TTN	7273	broad.mit.edu	37	chr2	179588378	179588378	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaaggttacatttttgcctGgtagtacttccaaaggttca	10	15	9	7	0	1	1	1	1	0	0	2	1	2	1	2	3	3	4	2	3	5	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179588378G>T	uc010zfg.1	-	71	17941	c.17717C>A	c.(17716-17718)CCA>CAA	p.P5906Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P2567Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6833							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTTTGCCTGGTAGTACTTC	0.433													11	27					0.00829132	0.00852929	1	0	T	179588378	T	T	179588378	3	4	58	1	0	0	0	0	1	0	0	0	16803	1348	47	4	83236	4	TTN	2	179588378	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	50962	179588378	63610995	74	11459											
TTN	7273	broad.mit.edu	37	chr2	179603084	179603084	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttttcctcttgatcactgggGcagctgcaaagggaagtaga	10	11	12	8	0	2	2	1	1	1	1	3	3	3	3	1	3	2	4	1	3	3	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179603084G>A	uc010zfg.1	-	46	10588	c.10364C>T	c.(10363-10365)GCC>GTC	p.A3455V	TTN_uc010zfh.1_Missense_Mutation_p.A4528V|TTN_uc010zfi.1_Missense_Mutation_p.A4461V|TTN_uc010zfj.1_Missense_Mutation_p.A4336V|TTN_uc002umz.1_Missense_Mutation_p.A116V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4382							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATCACTGGGGCAGCTGCAAA	0.453													11	43					0	0	0	0	A	179603084	A	A	179603084	3	1	58	1	0	0	0	0	1	0	0	0	16803	1203	42	4	90689	4	TTN	2	179603084	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	14706	179603084	63596289	75	11460											
TTN	7273	broad.mit.edu	37	chr2	179605479	179605479	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagaataccttctttggagaAggttttctgggactgtacaa	11	14	10	6	0	2	2	0	0	2	2	2	4	2	3	1	3	2	2	1	3	6	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179605479A>T	uc010zfh.1	-	46	12192	c.11968T>A	c.(11968-11970)TTC>ATC	p.F3990I	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.F3923I|TTN_uc010zfj.1_Missense_Mutation_p.F3798I|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTGGAGAAGGTTTTCTGG	0.448													50	158					0	0	0	0	T	179605479	T	T	179605479	3	4	58	1	0	0	0	0	1	0	0	0	16803	72	3	5	92308	5	TTN	2	179605479	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	2395	179605479	63593894	76	11461											
TTN	7273	broad.mit.edu	37	chr2	179611115	179611115	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aatcatacttttatggtcagGagtaaattcgggaactgtca	13	13	9	6	1	3	0	3	0	0	0	4	2	3	2	0	3	2	1	0	3	6	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179611115G>T	uc002unb.2	-	46	16236	c.16012C>A	c.(16012-16014)CCT>ACT	p.P5338T	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTATGGTCAGGAGTAAATTCG	0.348													21	89					1.01871e-10	1.27997e-10	1	0	T	179611115	T	T	179611115	3	4	58	1	0	0	0	0	1	0	0	0	16803	1174	41	2	94285	2	TTN	2	179611115	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5636	179611115	63588258	77	11462											
TTN	7273	broad.mit.edu	37	chr2	179611834	179611834	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctctagagtctctcctgggGgtgtggagtatctctccaga	6	12	13	10	0	3	2	0	0	3	2	7	3	5	3	2	3	0	2	2	3	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179611834G>T	uc002unb.2	-	46	15517	c.15293C>A	c.(15292-15294)CCC>CAC	p.P5098H	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTCCTGGGGGTGTGGAGTA	0.522													41	147					6.2361e-21	9.19218e-21	1	0	T	179611834	T	T	179611834	3	4	58	1	0	0	0	0	1	0	0	0	16803	1232	43	4	95004	4	TTN	2	179611834	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	719	179611834	63587539	78	11463											
TTN	7273	broad.mit.edu	37	chr2	179635394	179635394	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttcttcagagtcttcttaaTtttgacagctaaagacaaat	13	15	6	7	0	4	3	1	1	3	2	4	3	4	3	0	0	1	2	0	0	4	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179635394T>C	uc010zfg.1	-	35	8349	c.8125A>G	c.(8125-8127)ATT>GTT	p.I2709V	TTN_uc010zfh.1_Missense_Mutation_p.I2663V|TTN_uc010zfi.1_Missense_Mutation_p.I2663V|TTN_uc010zfj.1_Missense_Mutation_p.I2663V|TTN_uc002unb.2_Missense_Mutation_p.I2709V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2709							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTTCTTAATTTTGACAGCT	0.393													49	129					0	0	0	0	C	179635394	C	C	179635394	3	2	58	1	0	0	0	0	1	0	0	0	16803	1493	52	5	103175	5	TTN	2	179635394	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	23560	179635394	63563979	79	11464											
SESTD1	91404	broad.mit.edu	37	chr2	180014079	180014079	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgttaatcaaagcaagttCatctaataatgatgtagatt	16	15	6	4	0	3	2	2	1	1	1	3	2	3	2	0	0	1	4	0	0	6	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:180014079C>G	uc002uni.3	-	7	676	c.526G>C	c.(526-528)GAA>CAA	p.E176Q		NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	176					regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			AAAGCAAGTTCATCTAATAAT	0.289													13	34					0	0	0	0	G	180014079	G	G	180014079	3	3	58	1	0	0	0	0	1	0	0	0	14192	835	29	2	1612	2	SESTD1	2	180014079	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	378685	180014079	63185294	80	11465											
ZNF385B	151126	broad.mit.edu	37	chr2	180634252	180634252	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgctgctgttgctgctgggGctggcctgggcgggtggtgg	0	11	22	8	1	0	0	0	0	0	0	0	0	0	0	1	7	4	6	1	7	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:180634252G>C	uc002unn.3	-	3	835	c.231C>G	c.(229-231)AGC>AGG	p.S77R		NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	77						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TGCTGCTGGGGCTGGCCTGGG	0.607													9	61					0	0	0	0	C	180634252	C	C	180634252	3	2	58	1	0	0	0	0	1	0	0	0	17944	1194	42	4	1245	4	ZNF385B	2	180634252	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	620173	180634252	62565121	81	11466											
NEUROD1	4760	broad.mit.edu	37	chr2	182543323	182543323	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgagccttagtcatcttctTctttttggggccgcgtctct	3	16	10	12	3	5	0	1	0	4	0	6	1	5	0	2	2	1	0	2	2	1	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:182543323T>G	uc002uof.2	-	2	501	c.265A>C	c.(265-267)AAG>CAG	p.K89Q	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	89	Poly-Lys.|Nuclear localization signal (Potential).				amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			GTCATCTTCTTCTTTTTGGGG	0.413													10	37					0	0	0	0	G	182543323	G	G	182543323	3	3	58	1	0	0	0	0	1	0	0	0	10402	1792	62	5	809	5	NEUROD1	2	182543323	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1909071	182543323	60656050	82	11467											
DNAJC10	54431	broad.mit.edu	37	chr2	183594599	183594600	+	Missense_Mutation	DNP	AG	CT	CT																															cagtgaaatatcatggagacAgatcaaaggagagtttagtg																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:183594599_183594600AG>CT	uc002uow.1	+	8	1073_1074	c.658_659AG>CT	c.(658-660)AGA>CTA	p.R220L	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Missense_Mutation_p.R220L|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	220	Thioredoxin 1.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TCATGGAGACAGATCAAAGGAG	0.312													26	106					0	0	0	0	CT	183594600	CT	CT	183594599	3	2	58	1	0	0	0	0	1	0	0	0	4651	180	7	5	680	5	DNAJC10	2	183594599	Missense_Mutation	DNP	AG	TCGA-CN-5360-01A-01D-1434-08	1051276	183594599	59604774	83	11468											
CALCRL	10203	broad.mit.edu	37	chr2	188245205	188245205	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgacataccttcactttctCgtgggtgttaacattacact	10	15	6	10	1	2	1	1	1	1	0	3	1	2	1	1	1	3	1	1	1	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:188245205C>T	uc002upv.3	-	7	945	c.397G>A	c.(397-399)GAG>AAG	p.E133K	CALCRL_uc010frt.2_Missense_Mutation_p.E133K	NM_005795	NP_005786	Q16602	CALRL_HUMAN	calcitonin receptor-like precursor	133	Extracellular (Potential).					integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			TTCACTTTCTCGTGGGTGTTA	0.338													10	253					0	0	0	0	T	188245205	T	T	188245205	3	4	58	1	0	0	0	0	1	0	0	0	2592	893	31	1	1024	1	CALCRL	2	188245205	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	4650606	188245205	54954168	84	11469											
COL3A1	1281	broad.mit.edu	37	chr2	189870076	189870076	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttcattcctttgtatacagGgtgaaagtgggaaaccagga	12	12	11	6	0	1	1	1	1	0	0	2	3	2	3	2	3	2	1	2	3	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:189870076G>T	uc002uqj.1	+	41	3049	c.2932G>T	c.(2932-2934)GGT>TGT	p.G978C		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	978	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTGTATACAGGGTGAAAGTGG	0.413													32	150					1.45844e-13	1.92853e-13	1	0	T	189870076	T	T	189870076	3	4	58	1	0	0	0	0	1	0	0	0	3703	1246	43	4	3094	4	COL3A1	2	189870076	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1624871	189870076	53329297	85	11470											
SLC40A1	30061	broad.mit.edu	37	chr2	190430079	190430079	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agatcattgtgttcagtttaCctttgtgtaaattcagctgt	9	18	8	6	0	3	1	3	0	0	1	3	1	3	1	1	0	2	4	1	0	3	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:190430079C>A	uc002uqp.3	-	6	1111	c.760_splice	c.e6+1	p.D254_splice		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated						anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			GTTCAGTTTACCTTTGTGTAA	0.368													23	49					1.85244e-09	2.2527e-09	1	0	A	190430079	A	A	190430079	5	1	58	1	0	0	0	0	0	0	1	0	14692	521	18	4	966	4	SLC40A1	2	190430079	Splice_Site	SNP	C	TCGA-CN-5360-01A-01D-1434-08	560003	190430079	52769294	86	11471											
ANKRD44	91526	broad.mit.edu	37	chr2	197943433	197943433	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaaacaactcaccaattcCagacactgcctgtgcccata	15	7	4	15	0	1	1	1	0	0	1	2	1	2	1	4	0	4	0	4	0	5	2	rs146996314		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:197943433C>A	uc002uua.1	-	16	1646	c.1569G>T	c.(1567-1569)CTG>CTT	p.L523L	ANKRD44_uc002utz.3_Silent_p.L255L|ANKRD44_uc002uub.2_Silent_p.L548L|ANKRD44_uc010zgw.1_Silent_p.L476L	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	548	ANK 16.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCACCAATTCCAGACACTGCC	0.418													11	20					0.000219431	0.000234221	1	0	A	197943433	A	A	197943433	2	1	58	1	0	0	0	0	0	0	0	1	672	581	21	4		4	ANKRD44	2	197943433	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	7513354	197943433	45255940	87	11472											
KLF7	8609	broad.mit.edu	37	chr2	207989096	207989096	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgagatcctccggggctcCgtctgtaggtagcgttccaa	6	11	12	12	3	2	1	0	1	2	1	6	2	6	1	4	3	1	4	4	3	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:207989096C>G	uc002vbz.1	-	2	457	c.135G>C	c.(133-135)ACG>ACC	p.T45T	KLF7_uc002vca.1_Silent_p.T45T|KLF7_uc010zix.1_Silent_p.T17T	NM_003709	NP_003700	O75840	KLF7_HUMAN	Kruppel-like factor 7 (ubiquitous)	45					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			central_nervous_system(1)|skin(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)		TCCGGGGCTCCGTCTGTAGGT	0.557													9	24					0	0	0	0	G	207989096	G	G	207989096	2	3	58	1	0	0	0	0	0	0	0	1	8390	639	23	3		3	KLF7	2	207989096	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	10045663	207989096	35210277	88	11473											
FN1	2335	broad.mit.edu	37	chr2	216251534	216251534	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaattccgagagtggggcAcccgatcttctcgaggtctc	7	10	13	11	3	3	1	0	0	3	1	6	5	4	2	2	4	0	1	2	4	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:216251534A>C	uc002vfa.2	-	28	4756	c.4490T>G	c.(4489-4491)GTG>GGG	p.V1497G	FN1_uc002vfb.2_Missense_Mutation_p.V1406G|FN1_uc002vfc.2_Missense_Mutation_p.V1406G|FN1_uc002vfd.2_Missense_Mutation_p.V1497G|FN1_uc002vfe.2_Missense_Mutation_p.V1406G|FN1_uc002vff.2_Missense_Mutation_p.V1406G|FN1_uc002vfg.2_Missense_Mutation_p.V1406G|FN1_uc002vfh.2_Missense_Mutation_p.V1406G|FN1_uc002vfi.2_Missense_Mutation_p.V1497G|FN1_uc002vfj.2_Missense_Mutation_p.V1497G|FN1_uc002vez.2_5'UTR|FN1_uc010zjp.1_Missense_Mutation_p.V124G	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1496	Fibronectin type-III 10.|Cell-attachment.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAGTGGGGCACCCGATCTTC	0.542													12	40					0	0	0	0	C	216251534	C	C	216251534	3	2	58	1	0	0	0	0	1	0	0	0	5994	159	6	5	3019	5	FN1	2	216251534	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	8262438	216251534	26947839	89	11474											
CUL3	8452	broad.mit.edu	37	chr2	225400280	225400280	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctctaatcatcaccatagCtgtttgatgatcattccaag	11	14	6	10	0	4	2	3	2	1	0	6	2	5	2	2	0	1	2	2	0	3	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:225400280C>T	uc002vny.2	-	3	727	c.343G>A	c.(343-345)GCT>ACT	p.A115T	CUL3_uc010zls.1_Missense_Mutation_p.A49T|CUL3_uc010fwy.1_Missense_Mutation_p.A121T	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	115					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ATCACCATAGCTGTTTGATGA	0.313													13	35					0	0	0	0	T	225400280	T	T	225400280	3	4	58	1	0	0	0	0	1	0	0	0	4073	797	28	4	2019	4	CUL3	2	225400280	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	9148746	225400280	17799093	90	11475											
SPHKAP	80309	broad.mit.edu	37	chr2	228882377	228882377	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	actcagtaaccgattccgggGatagccctgcgcctgccaca	9	7	10	15	3	1	0	1	0	0	0	2	2	2	1	5	2	4	1	5	2	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:228882377G>T	uc002vpq.2	-	7	3240	c.3193C>A	c.(3193-3195)CCC>ACC	p.P1065T	SPHKAP_uc002vpp.2_Missense_Mutation_p.P1065T|SPHKAP_uc010zlx.1_Missense_Mutation_p.P1065T	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1065						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CGATTCCGGGGATAGCCCTGC	0.562													25	45					3.73808e-20	5.48628e-20	1	0	T	228882377	T	T	228882377	3	4	58	1	0	0	0	0	1	0	0	0	15114	1174	41	2	1933	2	SPHKAP	2	228882377	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3482097	228882377	14316996	91	11476											
SP140L	93349	broad.mit.edu	37	chr2	231249970	231249970	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgatggccagctggtctcGagtgaaaagaaggcgaacat	12	6	14	9	3	1	2	0	1	1	1	2	5	1	2	2	3	2	1	2	3	4	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:231249970G>A	uc010fxm.1	+	9	826	c.735G>A	c.(733-735)TCG>TCA	p.S245S	SP140L_uc010fxo.1_Silent_p.S52S	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	245						nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1						AGCTGGTCTCGAGTGAAAAGA	0.458													3	55					0	0	0	0	A	231249970	A	A	231249970	2	1	58	1	0	0	0	0	0	0	0	1	15027	1045	37	1		1	SP140L	2	231249970	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2367593	231249970	11949403	92	11477											
COL6A3	1293	broad.mit.edu	37	chr2	238296331	238296331	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaaagctacggaattccggGacagtaaacaccaagttgtc	14	7	9	11	2	0	0	0	0	0	0	2	2	1	2	3	2	3	3	3	2	6	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:238296331G>T	uc002vwl.2	-	4	1491	c.1206C>A	c.(1204-1206)GTC>GTA	p.V402V	COL6A3_uc002vwo.2_Silent_p.V196V|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Silent_p.V196V|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Silent_p.V402V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	402	VWFA 2.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGAATTCCGGGACAGTAAACA	0.542													4	21					0.00909568	0.00927269	1	0	T	238296331	T	T	238296331	2	4	58	1	0	0	0	0	0	0	0	1	3716	1161	41	2		2	COL6A3	2	238296331	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	7046361	238296331	4903042	93	11478											
OXTR	5021	broad.mit.edu	37	chr3	8809254	8809254	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaccggcacgatgtagacaGctagcgtgatccatgtgatg	10	9	13	9	3	0	4	0	3	0	1	1	5	1	4	2	1	2	3	2	1	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:8809254G>A	uc003brc.2	-	3	1242	c.620C>T	c.(619-621)GCT>GTT	p.A207V		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	207	Helical; Name=5; (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GATGTAGACAGCTAGCGTGAT	0.612													17	28					0	0	0	0	A	8809254	A	A	8809254	3	1	58	1	0	0	0	0	1	0	0	0	11392	971	34	4	557	4	OXTR	3	8809254	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08		8809254	189213176	94	11479											
SLC6A11	6538	broad.mit.edu	37	chr3	10861414	10861414	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcattggctatgcaacaCaggtgattgaggcccatctg	10	9	12	10	0	1	2	0	2	1	0	1	2	1	2	1	4	2	3	1	4	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:10861414C>G	uc003bvz.2	+	3	443	c.409C>G	c.(409-411)CAG>GAG	p.Q137E	SLC6A11_uc003bvy.1_Missense_Mutation_p.Q137E	NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	137	Helical; Name=3; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CTATGCAACACAGGTGATTGA	0.448													48	112					0	0	0	0	G	10861414	G	G	10861414	3	3	58	1	0	0	0	0	1	0	0	0	14738	479	17	4	419	4	SLC6A11	3	10861414	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2052160	10861414	187161016	95	11480											
C3orf20	84077	broad.mit.edu	37	chr3	14755664	14755664	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcactacaacctaaaaacCaggtaagtggactgggagag	15	7	11	8	0	1	1	1	0	0	1	1	3	1	2	2	3	3	2	2	3	6	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:14755664C>A	uc003byy.2	+	8	1715	c.1311C>A	c.(1309-1311)ACC>ACA	p.T437T	C3orf20_uc003byz.2_Silent_p.T315T|C3orf20_uc003bza.2_Silent_p.T315T|C3orf20_uc003bzb.1_5'UTR	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	437						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						ACCTAAAAACCAGGTAAGTGG	0.498													18	33					9.16793e-09	1.08769e-08	1	0	A	14755664	A	A	14755664	2	1	58	1	0	0	0	0	0	0	0	1	2223	581	21	4		4	C3orf20	3	14755664	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3894250	14755664	183266766	96	11481											
SH3BP5	9467	broad.mit.edu	37	chr3	15300345	15300345	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccctgacttaccagaaatGgcatcaggctcaggtttgct	9	10	10	12	0	2	2	2	1	0	1	2	2	2	2	3	3	2	4	3	3	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:15300345G>A	uc003bzp.1	-	7	1071	c.882C>T	c.(880-882)GCC>GCT	p.A294A	SH3BP5_uc010hem.1_RNA|SH3BP5_uc003bzq.1_Silent_p.A137A|SH3BP5_uc003bzr.1_Silent_p.A137A|uc003bzo.1_RNA	NM_004844	NP_004835	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	294	Ser-rich.				intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding				0						TACCAGAAATGGCATCAGGCT	0.572													18	37					0	0	0	0	A	15300345	A	A	15300345	2	1	58	1	0	0	0	0	0	0	0	1	14312	1335	47	4		4	SH3BP5	3	15300345	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	544681	15300345	182722085	97	11482											
ZNF385D	79750	broad.mit.edu	37	chr3	21478684	21478684	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttgatattgctggtgtccCtgcagtaccgtctgtattca	6	15	10	10	2	2	1	1	1	1	0	3	1	3	1	2	1	3	5	2	1	3	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:21478684C>A	uc003cce.2	-	5	859	c.451G>T	c.(451-453)GGG>TGG	p.G151W	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	151	Thr-rich.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GCTGGTGTCCCTGCAGTACCG	0.408													35	58					3.09479e-21	4.58163e-21	1	0	A	21478684	A	A	21478684	3	1	58	1	0	0	0	0	1	0	0	0	17945	681	24	4	752	4	ZNF385D	3	21478684	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	6178339	21478684	176543746	98	11483											
NEK10	152110	broad.mit.edu	37	chr3	27216146	27216146	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccactagcagtacctttcTcagcattttccaggttgaag	9	13	8	11	0	1	1	1	1	1	0	3	1	2	1	3	1	4	4	3	1	3	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:27216146T>C	uc010hfk.2	-	6	849	c.620A>G	c.(619-621)GAG>GGG	p.E207G	NEK10_uc003cds.1_Missense_Mutation_p.E292G|NEK10_uc010hfj.2_Missense_Mutation_p.E207G			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	895							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						AGTACCTTTCTCAGCATTTTC	0.483													41	103					0	0	0	0	C	27216146	C	C	27216146	3	2	58	1	0	0	0	0	1	0	0	0	10376	1566	54	5		5	NEK10	3	27216146	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	5737462	27216146	170806284	99	11484											
NEK10	152110	broad.mit.edu	37	chr3	27233635	27233635	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcttttccaaggacaactggGatgtagataagttgtctaaa	13	13	9	6	0	2	1	0	0	2	1	3	3	3	3	1	2	1	2	1	2	6	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:27233635G>C	uc010hfk.2	-	5	555	c.326C>G	c.(325-327)TCC>TGC	p.S109C	NEK10_uc003cds.1_Missense_Mutation_p.S194C|NEK10_uc010hfj.2_Missense_Mutation_p.S109C			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	797							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						GGACAACTGGGATGTAGATAA	0.448													32	73					0	0	0	0	C	27233635	C	C	27233635	3	2	58	1	0	0	0	0	1	0	0	0	10376	1189	41	2		2	NEK10	3	27233635	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	17489	27233635	170788795	100	11485											
SCN11A	11280	broad.mit.edu	37	chr3	38921582	38921582	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttagtaattcttggattttGggttggttctcaaggtgaac	8	18	11	4	0	2	1	1	1	2	0	3	2	2	2	0	4	1	3	0	4	4	9			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:38921582G>T	uc011ays.1	-	19	3451	c.3252C>A	c.(3250-3252)CCC>CCA	p.P1084P	SCN11A_uc010hhn.1_Silent_p.P162P	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1084	III.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.P1084P(1)		skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTGGATTTTGGGTTGGTTCT	0.338													13	32					1.36491e-13	1.80837e-13	1	0	T	38921582	T	T	38921582	2	4	58	1	0	0	0	0	0	0	0	1	13978	1335	47	4		4	SCN11A	3	38921582	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	11687947	38921582	159100848	101	11486											
TRAK1	22906	broad.mit.edu	37	chr3	42132991	42132991	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttttcaattcgggcagccCgtcagggctcagcctctgcc	5	11	11	14	2	4	0	3	0	1	0	5	0	4	0	3	2	3	3	3	2	1	3	rs144753843	by1000genomes	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:42132991C>G	uc003cky.2	+	1	246	c.30C>G	c.(28-30)CCC>CCG	p.P10P	TRAK1_uc011azh.1_Silent_p.P10P|TRAK1_uc011azi.1_Silent_p.P10P	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	10					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TCGGGCAGCCCGTCAGGGCTC	0.537													8	40					0	0	0	0	G	42132991	G	G	42132991	2	3	58	1	0	0	0	0	0	0	0	1	16516	639	23	3		3	TRAK1	3	42132991	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3211409	42132991	155889439	102	11487											
DOCK3	1795	broad.mit.edu	37	chr3	51263131	51263131	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaagggggatttcgagaGaggaggaaagagtgtacaaa	16	5	18	2	1	0	3	0	0	0	3	1	9	0	6	0	5	1	1	0	5	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:51263131G>T	uc011bds.1	+	15	1327	c.1304G>T	c.(1303-1305)AGA>ATA	p.R435I		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	435	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GATTTCGAGAGAGGAGGAAAG	0.463													44	74					7.53189e-24	1.14492e-23	1	0	T	51263131	T	T	51263131	3	4	58	1	0	0	0	0	1	0	0	0	4710	942	33	2	1362	2	DOCK3	3	51263131	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	9130140	51263131	146759299	103	11488											
GLT8D1	55830	broad.mit.edu	37	chr3	52734476	52734476	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catacctttacggaatgacaTctttttcttctgtcatataa	11	17	4	9	1	4	1	1	1	3	0	4	2	4	2	1	1	2	0	1	1	5	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:52734476T>A	uc003dfi.3	-	2	140	c.1A>T	c.(1-3)ATG>TTG	p.M1L	GLT8D1_uc003dfj.2_Missense_Mutation_p.M1L|GLT8D1_uc003dfk.2_Missense_Mutation_p.M1L|GLT8D1_uc003dfl.2_Missense_Mutation_p.M1L|GLT8D1_uc003dfm.2_Missense_Mutation_p.M1L|GLT8D1_uc003dfn.2_Missense_Mutation_p.M1L|GLT8D1_uc003dfo.1_Missense_Mutation_p.M1L|GLT8D1_uc010hmm.1_RNA	NM_152932	NP_690909	Q68CQ7	GL8D1_HUMAN	glycosyltransferase 8 domain containing 1	1	Cytoplasmic (Potential).					integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups				0				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CGGAATGACATCTTTTTCTTC	0.338													5	115					0	0	0	0	A	52734476	A	A	52734476	3	1	58	1	0	0	0	0	1	0	0	0	6506	1435	50	5	1150	5	GLT8D1	3	52734476	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1471345	52734476	145287954	104	11489											
SFMBT1	51460	broad.mit.edu	37	chr3	52977588	52977588	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcatcccaggagcaaatcCattttgcaaacgtgtgtcca	11	11	7	12	1	1	0	1	0	0	0	4	1	4	1	3	1	3	2	3	1	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:52977588C>A	uc003dgf.2	-	5	714	c.145G>T	c.(145-147)GGA>TGA	p.G49*	SFMBT1_uc010hmr.2_5'UTR|SFMBT1_uc003dgg.2_Nonsense_Mutation_p.G49*|SFMBT1_uc003dgh.2_Nonsense_Mutation_p.G49*	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	49	MBT 1.				regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		GGAGCAAATCCATTTTGCAAA	0.433													33	85					1.22384e-17	1.71136e-17	1	0	A	52977588	A	A	52977588	4	1	58	1	0	0	0	0	0	1	0	0	14222	603	21	4	2527	4	SFMBT1	3	52977588	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	243112	52977588	145044842	105	11490											
DNAH12	201625	broad.mit.edu	37	chr3	57496556	57496556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttttcaaagtcacttgacaCctcatttatgagactttcaa	12	15	5	9	0	4	2	4	2	0	1	4	3	4	2	1	0	0	1	1	0	3	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:57496556C>T	uc003dit.2	-	5	611	c.430G>A	c.(430-432)GTG>ATG	p.V144M	DNAH12_uc003diu.2_Missense_Mutation_p.V144M	NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	dynein heavy chain domain 2 isoform 1	144	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			pancreas(1)|skin(1)	2						TCACTTGACACCTCATTTATG	0.438													17	52					0	0	0	0	T	57496556	T	T	57496556	3	4	58	1	0	0	0	0	1	0	0	0	4622	507	18	4	9111	4	DNAH12	3	57496556	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	4518968	57496556	140525874	106	11491											
OR5H14	403273	broad.mit.edu	37	chr3	97868307	97868307	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caaccacagtggaaaataccCctgttcctggcattcttggt	10	11	8	12	0	1	0	0	0	1	0	2	1	2	1	4	3	2	2	4	3	4	4	rs146669592		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:97868307C>A	uc003dsg.1	+	1	78	c.78C>A	c.(76-78)CCC>CCA	p.P26P		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	26	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGAAAATACCCCTGTTCCTGG	0.418													162	224					1.8242e-84	3.00067e-84	1	0	A	97868307	A	A	97868307	2	1	58	1	0	0	0	0	0	0	0	1	11214	610	22	4		4	OR5H14	3	97868307	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	40371751	97868307	100154123	107	11492											
OR5H15	403274	broad.mit.edu	37	chr3	97887742	97887742	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acttactccttgggaatttaGcttttgtggatgcttggata	8	17	10	6	0	0	0	0	0	0	0	1	3	1	3	1	3	3	2	1	3	4	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:97887742G>C	uc011bgu.1	+	1	199	c.199G>C	c.(199-201)GCT>CCT	p.A67P		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGGGAATTTAGCTTTTGTGGA	0.403													64	247					0	0	0	0	C	97887742	C	C	97887742	3	2	58	1	0	0	0	0	1	0	0	0	11215	971	34	4	201	4	OR5H15	3	97887742	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	19435	97887742	100134688	108	11493											
COL8A1	1295	broad.mit.edu	37	chr3	99509677	99509677	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgccaccacaaattccacaaTaccagcccctgggtcagcaa	13	6	6	16	0	1	0	1	0	0	0	2	0	2	0	6	1	4	1	6	1	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:99509677T>C	uc003dtg.1	+	4	396	c.151T>C	c.(151-153)TAC>CAC	p.Y51H	COL8A1_uc003dth.1_Missense_Mutation_p.Y51H|COL8A1_uc003dti.1_Missense_Mutation_p.Y51H	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	51	Nonhelical region (NC2).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						AATTCCACAATACCAGCCCCT	0.537													19	74					0	0	0	0	C	99509677	C	C	99509677	3	2	58	1	0	0	0	0	1	0	0	0	3720	1406	49	5	153	5	COL8A1	3	99509677	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1621935	99509677	98512753	109	11494											
TRAT1	50852	broad.mit.edu	37	chr3	108557809	108557809	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagctactccagtgaccaCaccaggtatgttgtgattca	11	11	8	11	0	1	2	1	2	0	0	2	2	2	2	3	1	3	3	3	1	3	5	rs150919761		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:108557809C>A	uc003dxi.1	+	3	291	c.147C>A	c.(145-147)CAC>CAA	p.H49Q	TRAT1_uc010hpx.1_Missense_Mutation_p.H12Q	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	49	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						CCAGTGACCACACCAGGTATG	0.318													18	119					6.33239e-15	8.52244e-15	1	0	A	108557809	A	A	108557809	3	1	58	1	0	0	0	0	1	0	0	0	16533	477	17	4	157	4	TRAT1	3	108557809	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	9048132	108557809	89464621	110	11495											
MORC1	27136	broad.mit.edu	37	chr3	108822766	108822766	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtttttcattatccacTgtaagagaaagcagttatta	13	15	7	6	0	1	1	1	0	0	1	2	2	2	1	1	0	2	5	1	0	5	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:108822766T>A	uc003dxl.2	-	4	242	c.155_splice	c.e4-1	p.V52_splice	MORC1_uc011bhn.1_Splice_Site_p.V52_splice	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1						cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CATTATCCACTGTAAGAGAAA	0.398													45	133					0	0	0	0	A	108822766	A	A	108822766	5	1	58	1	0	0	0	0	0	0	1	0	9754	1594	55	5	2901	5	MORC1	3	108822766	Splice_Site	SNP	T	TCGA-CN-5360-01A-01D-1434-08	264957	108822766	89199664	111	11496											
DPPA4	55211	broad.mit.edu	37	chr3	109050622	109050622	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcacacaggcgcttatatgCatccaatttctaagacaata	14	10	7	10	1	1	1	0	0	1	1	2	1	2	1	1	2	1	3	1	2	6	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:109050622C>T	uc003dxq.3	-	4	404	c.349G>A	c.(349-351)GCA>ACA	p.A117T	DPPA4_uc011bho.1_Missense_Mutation_p.A117T|DPPA4_uc011bhp.1_Missense_Mutation_p.A117T	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	117						nucleus	protein binding			upper_aerodigestive_tract(1)	1						CGCTTATATGCATCCAATTTC	0.448													30	158					0	0	0	0	T	109050622	T	T	109050622	3	4	58	1	0	0	0	0	1	0	0	0	4758	710	25	4	581	4	DPPA4	3	109050622	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	227856	109050622	88971808	112	11497											
SLC9A10	285335	broad.mit.edu	37	chr3	111870716	111870716	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggcttacctgactttccttAggtttattctaggggactcc	6	16	9	10	0	1	1	0	1	1	0	3	2	3	2	3	4	1	2	3	4	4	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:111870716A>T	uc003dyu.2	-	28	3734	c.3512T>A	c.(3511-3513)CTA>CAA	p.L1171Q	SLC9A10_uc011bhu.1_Missense_Mutation_p.L434Q|SLC9A10_uc010hqc.2_Missense_Mutation_p.L1123Q	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	1171					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						GACTTTCCTTAGGTTTATTCT	0.522													51	109					0	0	0	0	T	111870716	T	T	111870716	3	4	58	1	0	0	0	0	1	0	0	0	14774	420	15	5	29	5	SLC9A10	3	111870716	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	2820094	111870716	86151714	113	11498											
SLC35A5	55032	broad.mit.edu	37	chr3	112299779	112299779	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catacagaacagcaaactctAtttctttggcattctgttta	12	15	5	9	0	3	1	0	0	3	1	3	1	3	1	0	1	4	3	0	1	5	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:112299779A>G	uc003dze.2	+	6	1060	c.815A>G	c.(814-816)TAT>TGT	p.Y272C		NM_017945	NP_060415	Q9BS91	S35A5_HUMAN	solute carrier family 35, member A5	272	Helical; (Potential).					Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1						AGCAAACTCTATTTCTTTGGC	0.388													24	93					0	0	0	0	G	112299779	G	G	112299779	3	3	58	1	0	0	0	0	1	0	0	0	14638	449	16	5	833	5	SLC35A5	3	112299779	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	429063	112299779	85722651	114	11499											
KIAA2018	205717	broad.mit.edu	37	chr3	113375785	113375785	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atggttccgactagttgaagGgttttcacagctcttctctg	7	15	10	9	1	3	1	1	1	2	0	5	2	4	1	1	2	1	4	1	2	2	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:113375785G>A	uc003eam.2	-	7	5155	c.4744C>T	c.(4744-4746)CCT>TCT	p.P1582S	KIAA2018_uc003eal.2_Missense_Mutation_p.P1526S	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1582	Gln-rich.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						CTAGTTGAAGGGTTTTCACAG	0.498													43	73					0	0	0	0	A	113375785	A	A	113375785	3	1	58	1	0	0	0	0	1	0	0	0	8307	1232	43	4	1997	4	KIAA2018	3	113375785	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1076006	113375785	84646645	115	11500											
ZNF80	7634	broad.mit.edu	37	chr3	113955434	113955434	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtttttccacattctttgCacccaaagagtttttctcca	9	16	5	11	0	2	1	0	0	2	1	4	1	3	1	3	1	1	3	3	1	1	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:113955434C>A	uc010hqo.2	-	1	992	c.488G>T	c.(487-489)TGC>TTC	p.C163F	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	163	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				ACATTCTTTGCACCCAAAGAG	0.488													32	190					4.65686e-17	6.44578e-17	1	0	A	113955434	A	A	113955434	3	1	58	1	0	0	0	0	1	0	0	0	18235	710	25	4	337	4	ZNF80	3	113955434	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	579649	113955434	84066996	116	11501											
ADPRH	141	broad.mit.edu	37	chr3	119305452	119305452	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagctaaaaagtacattGtccaatcaggctactttgta	15	11	7	8	0	1	1	1	0	0	1	2	1	2	1	1	1	3	4	1	1	8	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:119305452G>T	uc003ecs.2	+	4	917	c.619G>T	c.(619-621)GTC>TTC	p.V207F	ADPRH_uc010hqv.2_Missense_Mutation_p.V207F|ADPRH_uc011bjb.1_Missense_Mutation_p.V100F|ADPRH_uc003ect.2_Missense_Mutation_p.V207F	NM_001125	NP_001116	P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	207					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			ovary(1)	1		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		AAAGTACATTGTCCAATCAGG	0.483													36	121					6.02846e-25	9.26722e-25	1	0	T	119305452	T	T	119305452	3	4	58	1	0	0	0	0	1	0	0	0	331	1377	48	4	625	4	ADPRH	3	119305452	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5350018	119305452	78716978	117	11502											
GOLGB1	2804	broad.mit.edu	37	chr3	121413755	121413755	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaggtatttttctcatttTctaaagtctggctaaattcc	10	18	6	7	0	3	0	1	0	3	0	5	0	4	0	1	2	0	3	1	2	6	9			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:121413755T>G	uc003eei.3	-	13	5726	c.5600A>C	c.(5599-5601)GAA>GCA	p.E1867A	GOLGB1_uc010hrc.2_Missense_Mutation_p.E1872A|GOLGB1_uc003eej.3_Missense_Mutation_p.E1833A|GOLGB1_uc011bjm.1_Missense_Mutation_p.E1753A|GOLGB1_uc010hrd.1_Missense_Mutation_p.E1831A	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1867	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTTCTCATTTTCTAAAGTCTG	0.353													87	340					0	0	0	0	G	121413755	G	G	121413755	3	3	58	1	0	0	0	0	1	0	0	0	6602	1783	62	5	4219	5	GOLGB1	3	121413755	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	2108303	121413755	76608675	118	11503											
PARP9	83666	broad.mit.edu	37	chr3	122247277	122247277	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaagggtctcattggtccTgatgagtaatcttgtgactg	9	13	12	7	0	2	3	1	3	2	0	4	3	3	3	1	2	0	2	1	2	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:122247277T>C	uc010hri.2	-	11	2644	c.2499A>G	c.(2497-2499)TCA>TCG	p.S833S	PARP9_uc003eff.3_Silent_p.S798S|PARP9_uc011bjs.1_Silent_p.S798S|PARP9_uc003efg.2_Silent_p.S378S|PARP9_uc003efi.2_Silent_p.S798S|PARP9_uc003efh.2_Silent_p.S833S	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	833	PARP catalytic.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		TCATTGGTCCTGATGAGTAAT	0.453													35	136					0	0	0	0	C	122247277	C	C	122247277	2	2	58	1	0	0	0	0	0	0	0	1	11520	1567	55	5		5	PARP9	3	122247277	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	833522	122247277	75775153	119	11504											
SLC12A8	84561	broad.mit.edu	37	chr3	124802771	124802771	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctgctcccggttcacgaggGaggagtggtggtagcgatcc	6	8	17	10	3	1	0	1	0	0	0	3	4	3	2	2	5	2	4	2	5	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:124802771G>T	uc003ehv.3	-	14	2219	c.2108C>A	c.(2107-2109)TCC>TAC	p.S703Y	SLC12A8_uc003ehw.3_Missense_Mutation_p.S732Y|SLC12A8_uc003eht.3_Missense_Mutation_p.S504Y|SLC12A8_uc003ehu.3_Missense_Mutation_p.S456Y|SLC12A8_uc010hry.2_3'UTR	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	703					potassium ion transport	integral to membrane	symporter activity				0						GTTCACGAGGGAGGAGTGGTG	0.572													4	32					0.00909568	0.00927269	1	0	T	124802771	T	T	124802771	3	4	58	1	0	0	0	0	1	0	0	0	14454	1174	41	2	40	2	SLC12A8	3	124802771	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2555494	124802771	73219659	120	11505											
CHST13	166012	broad.mit.edu	37	chr3	126255138	126255138	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggaaacagagccctgggctCcagctggcttggtggggaga	8	7	17	9	0	0	2	0	0	0	2	1	4	1	3	2	6	3	3	2	6	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:126255138C>A	uc003eja.2	+	2	122	c.122C>A	c.(121-123)TCC>TAC	p.S41Y		NM_152889	NP_690849	Q8NET6	CHSTD_HUMAN	carbohydrate sulfotransferase 13	41	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.151)		GCCCTGGGCTCCAGCTGGCTT	0.592													21	122					2.27525e-19	3.2967e-19	1	0	A	126255138	A	A	126255138	3	1	58	1	0	0	0	0	1	0	0	0	3416	855	30	2	128	2	CHST13	3	126255138	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1452367	126255138	71767292	121	11506											
EPHB1	2047	broad.mit.edu	37	chr3	134825427	134825427	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accgagcggactttgaccctCcagaagtggcatgcactagt	10	8	11	12	2	0	2	0	1	0	1	1	4	1	3	3	2	2	2	3	2	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:134825427C>A	uc003eqt.2	+	4	1163	c.943C>A	c.(943-945)CCA>ACA	p.P315T	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Silent_p.L203L|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	315	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CTTTGACCCTCCAGAAGTGGC	0.587													17	57					5.3912e-06	5.91209e-06	1	0	A	134825427	A	A	134825427	3	1	58	1	0	0	0	0	1	0	0	0	5198	855	30	2	957	2	EPHB1	3	134825427	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	8570289	134825427	63197003	122	11507											
STAG1	10274	broad.mit.edu	37	chr3	136192475	136192475	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aacacttcagcctgacttccCcttgcttcagaaatacaaat	13	11	4	13	0	2	2	2	1	0	1	3	2	3	2	3	0	4	1	3	0	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:136192475C>A	uc003era.1	-	11	1323	c.1031G>T	c.(1030-1032)GGG>GTG	p.G344V	STAG1_uc003erb.1_Missense_Mutation_p.G344V|STAG1_uc003erc.1_Missense_Mutation_p.G118V|STAG1_uc010hua.1_Missense_Mutation_p.G207V	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	344	SCD.				cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						CCTGACTTCCCCTTGCTTCAG	0.348													10	88					2.80697e-09	3.3773e-09	1	0	A	136192475	A	A	136192475	3	1	58	1	0	0	0	0	1	0	0	0	15308	623	22	4	2841	4	STAG1	3	136192475	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1367048	136192475	61829955	123	11508											
CEP70	80321	broad.mit.edu	37	chr3	138289944	138289944	+	Frame_Shift_Del	DEL	C	-	-																															catgatgtttcttccaccaaCaatttcaaattctgtctcat																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:138289944delC	uc003esl.2	-	5	414	c.216delG	c.(214-216)TTGfs	p.L72fs	CEP70_uc011bmk.1_Frame_Shift_Del_p.L52fs|CEP70_uc011bml.1_Frame_Shift_Del_p.L54fs|CEP70_uc011bmm.1_Intron|CEP70_uc003esm.2_Frame_Shift_Del_p.L72fs|CEP70_uc003esn.2_Frame_Shift_Del_p.L72fs	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	72					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						CTTCCACCAACAATTTCAAAT	0.303													---	---	---								-	138289944	-	-	138289944	7	5	58	1	0	1	0	1	0	0	0	0	3274	477	17	0	1633	0	CEP70	3	138289944	Frame_Shift_Del	DEL	C	TCGA-CN-5360-01A-01D-1434-08	2097469	138289944	59732486	124	11509											
CLSTN2	64084	broad.mit.edu	37	chr3	140281733	140281733	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccggcttcccttgaggccCggcgtttccggattaagtgc	4	11	13	13	4	0	1	0	1	0	0	3	2	3	2	4	4	1	2	4	4	1	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:140281733C>A	uc003etn.2	+	14	2483	c.2293C>A	c.(2293-2295)CGG>AGG	p.R765R		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	765	Extracellular (Potential).		R -> Q (in a colorectal cancer sample; somatic mutation).		homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding	p.R765Q(1)		skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CCTTGAGGCCCGGCGTTTCCG	0.572										HNSCC(16;0.037)			11	72					3.86212e-05	4.14843e-05	1	0	A	140281733	A	A	140281733	2	1	58	1	0	0	0	0	0	0	0	1	3577	643	23	3		3	CLSTN2	3	140281733	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1991789	140281733	57740697	125	11510											
TRPC1	7220	broad.mit.edu	37	chr3	142522827	142522827	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgtctttacaggttcattgGcacctgctttgctttgttct	4	20	8	9	0	3	0	1	0	2	0	3	0	3	0	1	2	3	5	1	2	1	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:142522827G>T	uc003evc.2	+	11	1902	c.1766G>T	c.(1765-1767)GGC>GTC	p.G589V	TRPC1_uc003evb.2_Missense_Mutation_p.G555V|TRPC1_uc011bni.1_Missense_Mutation_p.G108V	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	589	Helical; (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AGGTTCATTGGCACCTGCTTT	0.328													22	108					1.10923e-09	1.36106e-09	1	0	T	142522827	T	T	142522827	3	4	58	1	0	0	0	0	1	0	0	0	16645	1203	42	4	1702	4	TRPC1	3	142522827	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2241094	142522827	55499603	126	11511											
PLOD2	5352	broad.mit.edu	37	chr3	145799596	145799596	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccatcaggactcaatgctccCcagaaattggaccacagctt	12	8	7	14	0	2	1	2	0	0	1	3	3	3	3	4	2	2	2	4	2	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:145799596C>A	uc003evs.1	-	12	1793	c.1287G>T	c.(1285-1287)TGG>TGT	p.W429C	PLOD2_uc003evq.1_Missense_Mutation_p.W89C|PLOD2_uc011bnm.1_Missense_Mutation_p.W374C|PLOD2_uc003evr.1_Missense_Mutation_p.W429C	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	429					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	TCAATGCTCCCCAGAAATTGG	0.378													15	106					2.32078e-09	2.8122e-09	1	0	A	145799596	A	A	145799596	3	1	58	1	0	0	0	0	1	0	0	0	12157	624	22	4	1025	4	PLOD2	3	145799596	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3276769	145799596	52222834	127	11512											
PLSCR5	389158	broad.mit.edu	37	chr3	146307593	146307593	+	Frame_Shift_Del	DEL	G	-	-																															attgtaagcttttcattaatGgttttcacctttagaaagaa																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:146307593delG	uc003ewb.2	-	6	1628	c.624delC	c.(622-624)ACCfs	p.T208fs	PLSCR5_uc010hvb.2_Frame_Shift_Del_p.T196fs|PLSCR5_uc010hvc.2_Frame_Shift_Del_p.T208fs	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	208											0						TTTCATTAATGGTTTTCACCT	0.318													---	---	---								-	146307593	-	-	146307593	7	5	58	1	0	1	0	1	0	0	0	0	12168	1335	47	0	199	0	PLSCR5	3	146307593	Frame_Shift_Del	DEL	G	TCGA-CN-5360-01A-01D-1434-08	507997	146307593	51714837	128	11513											
ZIC4	84107	broad.mit.edu	37	chr3	147114163	147114163	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtccattcaaaggacggctgGgggaggcctggggaggctcc	7	6	18	10	1	1	0	1	0	0	0	3	3	3	3	3	8	0	2	3	8	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:147114163G>T	uc003ewd.1	-	3	437	c.164C>A	c.(163-165)CCC>CAC	p.P55H	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Missense_Mutation_p.P105H	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	55						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						AGGACGGCTGGGGGAGGCCTG	0.716													10	38					1.58986e-06	1.76911e-06	1	0	T	147114163	T	T	147114163	3	4	58	1	0	0	0	0	1	0	0	0	17748	1232	43	4	852	4	ZIC4	3	147114163	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	806570	147114163	50908267	129	11514											
ZIC1	7545	broad.mit.edu	37	chr3	147130344	147130344	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgagtttgagggctgtgaccGgcgcttcgctaacagcagcg	7	8	15	11	5	0	2	0	2	0	0	1	3	0	2	1	2	3	5	1	2	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:147130344G>C	uc003ewe.2	+	2	1741	c.1022G>C	c.(1021-1023)CGG>CCG	p.R341P		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	341	C2H2-type 4.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GGCTGTGACCGGCGCTTCGCT	0.532													29	117					0	0	0	0	C	147130344	C	C	147130344	3	2	58	1	0	0	0	0	1	0	0	0	17745	1116	39	3	1028	3	ZIC1	3	147130344	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	16181	147130344	50892086	130	11515											
ZIC1	7545	broad.mit.edu	37	chr3	147131168	147131168	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcctcctcgcagggctcgCagccttcgccggccgccagc	5	6	11	19	5	0	0	0	0	0	0	5	0	2	0	6	2	2	3	6	2	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:147131168C>T	uc003ewe.2	+	3	1893	c.1174C>T	c.(1174-1176)CAG>TAG	p.Q392*		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	392	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GCAGGGCTCGCAGCCTTCGCC	0.622													21	147					0	0	0	0	T	147131168	T	T	147131168	4	4	58	1	0	0	0	0	0	1	0	0	17745	711	25	4	1184	4	ZIC1	3	147131168	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	824	147131168	50891262	131	11516											
ZIC1	7545	broad.mit.edu	37	chr3	147131266	147131266	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accacaagctccttatcgccCtcctcctccgcagtccacca	8	8	4	21	2	0	0	0	0	0	0	6	0	5	0	8	0	1	2	8	0	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:147131266C>A	uc003ewe.2	+	3	1991	c.1272C>A	c.(1270-1272)CCC>CCA	p.P424P		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	424	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCTTATCGCCCTCCTCCTCCG	0.562													25	163					4.72057e-08	5.48585e-08	1	0	A	147131266	A	A	147131266	2	1	58	1	0	0	0	0	0	0	0	1	17745	668	24	4		4	ZIC1	3	147131266	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	98	147131266	50891164	132	11517											
TSC22D2	9819	broad.mit.edu	37	chr3	150128674	150128674	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccaaacgtgcctgcagccGtgcccgctccaagcgtgcct	6	8	10	17	4	0	0	0	0	0	0	2	0	2	0	6	0	7	2	6	0	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:150128674G>T	uc003exv.2	+	1	1887	c.1537G>T	c.(1537-1539)GTG>TTG	p.V513L	TSC22D2_uc003exw.2_RNA|TSC22D2_uc003exx.2_Missense_Mutation_p.V513L	NM_014779	NP_055594	O75157	T22D2_HUMAN	TSC22 domain family, member 2	513							sequence-specific DNA binding transcription factor activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GCCTGCAGCCGTGCCCGCTCC	0.647													8	55					2.17888e-05	2.35901e-05	1	0	T	150128674	T	T	150128674	3	4	58	1	0	0	0	0	1	0	0	0	16675	1145	40	3	1539	3	TSC22D2	3	150128674	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2997408	150128674	47893756	133	11518											
MED12L	116931	broad.mit.edu	37	chr3	151067863	151067863	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggatgaatcttcaagtcAtgaatgtaaccagcgcacaa	15	9	8	9	1	4	2	3	2	1	0	4	3	4	3	1	1	2	2	1	1	5	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:151067863A>T	uc003eyp.2	+	15	2200	c.2162A>T	c.(2161-2163)CAT>CTT	p.H721L	MED12L_uc011bnz.1_Missense_Mutation_p.H581L|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	721					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTTCAAGTCATGAATGTAAC	0.433													100	592					0	0	0	0	T	151067863	T	T	151067863	3	4	58	1	0	0	0	0	1	0	0	0	9482	217	8	5	2220	5	MED12L	3	151067863	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	939189	151067863	46954567	134	11519											
MME	4311	broad.mit.edu	37	chr3	154861232	154861232	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcctttttcttttccgtagGccctttatggtacaacctca	6	18	5	12	1	2	0	1	0	1	0	4	0	4	0	4	2	2	2	4	2	4	9			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:154861232G>T	uc010hvr.1	+	13	1400	c.1189G>T	c.(1189-1191)GCC>TCC	p.A397S	MME_uc003fab.1_Missense_Mutation_p.A397S|MME_uc003fac.1_Missense_Mutation_p.A397S|MME_uc003fad.1_Missense_Mutation_p.A397S|MME_uc003fae.1_Missense_Mutation_p.A397S	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	397	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TTTTCCGTAGGCCCTTTATGG	0.418													29	219					1.75199e-13	2.31221e-13	1	0	T	154861232	T	T	154861232	3	4	58	1	0	0	0	0	1	0	0	0	9698	1217	42	4	1235	4	MME	3	154861232	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3793369	154861232	43161198	135	11520											
IL12A	3592	broad.mit.edu	37	chr3	159711264	159711264	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttgcctaaattccagagaGacctctttcataactgtaag	13	12	7	9	0	2	2	1	0	1	2	3	3	3	2	3	0	2	2	3	0	4	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:159711264G>A	uc003fcx.2	+	4	620	c.405G>A	c.(403-405)GAG>GAA	p.E135E	uc003fcw.1_Intron	NM_000882	NP_000873	P29459	IL12A_HUMAN	interleukin 12A precursor	101					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ATTCCAGAGAGACCTCTTTCA	0.313													10	100					0	0	0	0	A	159711264	A	A	159711264	2	1	58	1	0	0	0	0	0	0	0	1	7663	933	33	2		2	IL12A	3	159711264	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	4850032	159711264	38311166	136	11521											
IFT80	57560	broad.mit.edu	37	chr3	160037641	160037641	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacgacatgtccatttccAcaggctccagcaatctgagt	13	9	7	12	1	1	1	0	1	1	0	4	2	4	1	3	1	2	2	3	1	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:160037641A>G	uc011boy.1	-	9	1297	c.864T>C	c.(862-864)TGT>TGC	p.C288C	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Silent_p.C151C|IFT80_uc003fdd.1_5'UTR|IFT80_uc003fde.1_Silent_p.C151C	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	288	WD 6.					cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GTCCATTTCCACAGGCTCCAG	0.408													45	145					0	0	0	0	G	160037641	G	G	160037641	2	3	58	1	0	0	0	0	0	0	0	1	7603	157	6	5		5	IFT80	3	160037641	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	326377	160037641	37984789	137	11522											
SLITRK3	22865	broad.mit.edu	37	chr3	164906635	164906635	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gactgctgagaaaaacagaaCcagcaggctgagaattaaca	18	5	10	8	0	0	3	0	2	0	3	0	6	0	3	1	1	5	3	1	1	5	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:164906635C>A	uc003fej.3	-	2	2428	c.1984G>T	c.(1984-1986)GTT>TTT	p.V662F	SLITRK3_uc003fek.2_Missense_Mutation_p.V662F	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	662	Helical; (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						AAAAACAGAACCAGCAGGCTG	0.527										HNSCC(40;0.11)			15	52					1.3612e-06	1.51964e-06	1	0	A	164906635	A	A	164906635	3	1	58	1	0	0	0	0	1	0	0	0	14808	507	18	4	953	4	SLITRK3	3	164906635	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	4868994	164906635	33115795	138	11523											
WDR49	151790	broad.mit.edu	37	chr3	167272580	167272580	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgacaatatccattgaagtCccatatctttaagagaaaaa	17	11	6	7	0	1	3	0	2	1	1	3	4	3	3	2	0	0	0	2	0	7	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:167272580C>T	uc003fev.1	-	6	964	c.658G>A	c.(658-660)GAC>AAC	p.D220N	WDR49_uc003feu.1_Missense_Mutation_p.D45N|WDR49_uc011bpd.1_Missense_Mutation_p.D273N|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	220	WD 4.									large_intestine(1)|ovary(1)|skin(1)	3						CCATTGAAGTCCCATATCTTT	0.323													56	219					0	0	0	0	T	167272580	T	T	167272580	3	4	58	1	0	0	0	0	1	0	0	0	17370	855	30	2	1475	2	WDR49	3	167272580	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2365945	167272580	30749850	139	11524											
SAMD7	344658	broad.mit.edu	37	chr3	169639112	169639112	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatggcaaatgtgttgtccaGtcggatctacccaggtatga	10	12	11	8	1	1	1	0	1	1	0	3	2	2	2	2	3	1	3	2	3	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:169639112G>A	uc003fgd.2	+	4	464	c.197G>A	c.(196-198)AGT>AAT	p.S66N	SAMD7_uc003fge.2_Missense_Mutation_p.S66N|SAMD7_uc011bpo.1_5'UTR	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	66										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GTGTTGTCCAGTCGGATCTAC	0.438													35	185					0	0	0	0	A	169639112	A	A	169639112	3	1	58	1	0	0	0	0	1	0	0	0	13889	1029	36	4	203	4	SAMD7	3	169639112	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2366532	169639112	28383318	140	11525											
FNDC3B	64778	broad.mit.edu	37	chr3	172046816	172046816	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagttgacaaagctttgtccGgcaatggggtacacattcag	12	10	11	8	1	1	1	1	1	0	0	2	1	2	1	1	3	2	4	1	3	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:172046816G>T	uc003fhy.2	+	12	1501	c.1329G>T	c.(1327-1329)CCG>CCT	p.P443P	FNDC3B_uc003fhz.3_Silent_p.P443P|FNDC3B_uc003fia.2_Silent_p.P374P	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	443	Fibronectin type-III 2.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		AGCTTTGTCCGGCAATGGGGT	0.473													29	164					2.47511e-08	2.90612e-08	1	0	T	172046816	T	T	172046816	2	4	58	1	0	0	0	0	0	0	0	1	6002	1103	39	3		3	FNDC3B	3	172046816	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2407704	172046816	25975614	141	11526											
PIK3CA	5290	broad.mit.edu	37	chr3	178948139	178948139	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagtaaaggagcccaagaaTgcacaaagacaagagaattt	19	7	9	6	0	0	3	0	0	0	3	0	5	0	4	1	1	2	2	1	1	8	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:178948139T>C	uc003fjk.2	+	20	3068	c.2911T>C	c.(2911-2913)TGC>CGC	p.C971R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	971	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGCCCAAGAATGCACAAAGAC	0.343		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			21	124					0	0	0	0	C	178948139	C	C	178948139	3	2	58	1	0	0	0	0	1	0	0	0	11968	1464	51	5	2985	5	PIK3CA	3	178948139	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	6901323	178948139	19074291	142	11527											
TTC14	151613	broad.mit.edu	37	chr3	180321002	180321002	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tttccgagatattgagcgtgGtgatatagtgattggaagaa	12	13	13	3	2	0	5	0	3	0	2	1	7	1	6	1	2	1	0	1	2	5	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:180321002G>T	uc003fkk.2	+	3	509	c.377G>T	c.(376-378)GGT>GTT	p.G126V	TTC14_uc003fkl.2_Missense_Mutation_p.G126V|TTC14_uc003fkm.2_Missense_Mutation_p.G126V	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	126	S1 motif.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ATTGAGCGTGGTGATATAGTG	0.378													43	245					4.67007e-22	6.94392e-22	1	0	T	180321002	T	T	180321002	3	4	58	1	0	0	0	0	1	0	0	0	16749	1261	44	4	387	4	TTC14	3	180321002	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1372863	180321002	17701428	143	11528											
B3GNT5	84002	broad.mit.edu	37	chr3	182987805	182987805	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acctcagcggggcctcgctaCcaatacttgattaaccacaa	12	8	7	14	2	1	1	1	1	0	0	2	1	1	1	4	2	4	1	4	2	5	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:182987805C>T	uc003flk.2	+	2	749	c.219C>T	c.(217-219)TAC>TAT	p.Y73Y	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Silent_p.Y73Y|B3GNT5_uc003flm.2_Silent_p.Y73Y	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	73	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GGCCTCGCTACCAATACTTGA	0.418													39	159					0	0	0	0	T	182987805	T	T	182987805	2	4	58	1	0	0	0	0	0	0	0	1	1262	518	18	4		4	B3GNT5	3	182987805	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2666803	182987805	15034625	144	11529											
HTR3E	285242	broad.mit.edu	37	chr3	183824076	183824076	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccggggagatgctgtccCactgcgccccagaaggaaaa	11	4	13	13	2	0	2	0	0	0	2	1	4	1	3	4	3	3	1	4	3	3	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:183824076C>A	uc010hxq.2	+	8	1552	c.1086C>A	c.(1084-1086)CCC>CCA	p.P362P	HTR3E_uc003fml.3_Silent_p.P347P|HTR3E_uc003fmm.2_Silent_p.P377P|HTR3E_uc010hxr.2_Silent_p.P388P|HTR3E_uc003fmn.2_Silent_p.P362P	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	362	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GATGCTGTCCCACTGCGCCCC	0.577													12	60					0.000978159	0.00102481	1	0	A	183824076	A	A	183824076	2	1	58	1	0	0	0	0	0	0	0	1	7487	581	21	4		4	HTR3E	3	183824076	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	836271	183824076	14198354	145	11530											
TBCCD1	55171	broad.mit.edu	37	chr3	186272075	186272075	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcctccttcacagttttctgCcagatctgtatcttctgttc	5	17	6	13	0	5	1	1	0	4	1	7	1	6	1	3	0	1	3	3	0	1	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:186272075C>A	uc003fqg.2	-	6	1641	c.1512G>T	c.(1510-1512)TGG>TGT	p.W504C	TBCCD1_uc011bry.1_Missense_Mutation_p.W504C|TBCCD1_uc003fqh.2_Missense_Mutation_p.W408C	NM_018138	NP_060608	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	504					cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			large_intestine(1)|ovary(1)	2	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		CAGTTTTCTGCCAGATCTGTA	0.408													45	246					1.41504e-22	2.12724e-22	1	0	A	186272075	A	A	186272075	3	1	58	1	0	0	0	0	1	0	0	0	15698	740	26	4	169	4	TBCCD1	3	186272075	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2447999	186272075	11750355	146	11531											
ATP13A3	79572	broad.mit.edu	37	chr3	194149640	194149640	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggaagtctcctaggttacTtaagatctacagaagtaatt	13	13	8	7	0	2	2	0	0	2	2	3	3	2	3	1	2	2	2	1	2	7	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:194149640T>G	uc003fty.3	-	27	3283	c.2881A>C	c.(2881-2883)AGT>CGT	p.S961R		NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	961	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CCTAGGTTACTTAAGATCTAC	0.294													16	66					0	0	0	0	G	194149640	G	G	194149640	3	3	58	1	0	0	0	0	1	0	0	0	1127	1609	56	5	823	5	ATP13A3	3	194149640	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	7877565	194149640	3872790	147	11532											
TMEM44	93109	broad.mit.edu	37	chr3	194336360	194336360	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgggtgtcagggctctctcTggcttccttggcaaatccta	5	14	11	11	0	3	0	1	0	2	0	6	0	5	0	2	4	0	3	2	4	2	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:194336360T>A	uc010hzn.2	-	8	1160	c.991A>T	c.(991-993)AGA>TGA	p.R331*	TMEM44_uc010hzm.2_Nonsense_Mutation_p.R16*|TMEM44_uc003fuc.2_Nonsense_Mutation_p.R16*|TMEM44_uc003fue.2_Nonsense_Mutation_p.R284*|TMEM44_uc003fud.2_Nonsense_Mutation_p.R284*|TMEM44_uc003fuf.2_Nonsense_Mutation_p.R284*|TMEM44_uc011bsv.1_Nonsense_Mutation_p.R284*|TMEM44_uc003fuh.1_RNA	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	331	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		GGGCTCTCTCTGGCTTCCTTG	0.478													104	390					0	0	0	0	A	194336360	A	A	194336360	4	1	58	1	0	0	0	0	0	1	0	0	16234	1588	55	5	486	5	TMEM44	3	194336360	Nonsense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	186720	194336360	3686070	148	11533											
UBXN7	26043	broad.mit.edu	37	chr3	196129879	196129879	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttttgaggaattggggcaCgaacttcttctctattaaaa	11	14	9	7	1	2	1	0	1	2	0	3	3	2	2	0	3	1	2	0	3	5	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:196129879C>T	uc003fwm.3	-	3	308	c.233G>A	c.(232-234)CGT>CAT	p.R78H	UBXN7_uc003fwn.3_Translation_Start_Site|UBXN7_uc010iae.2_Intron|UBXN7_uc010iaf.2_Missense_Mutation_p.R78H	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	78							protein binding			ovary(2)|pancreas(1)	3						AATTGGGGCACGAACTTCTTC	0.318													56	373					0	0	0	0	T	196129879	T	T	196129879	3	4	58	1	0	0	0	0	1	0	0	0	16986	536	19	1	1272	1	UBXN7	3	196129879	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1793519	196129879	1892551	149	11534											
IQCG	84223	broad.mit.edu	37	chr3	197665493	197665493	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttttttgaagacaagatcCtgcattttgttaaactccac	11	15	7	8	0	0	3	0	1	0	2	2	3	2	3	2	1	2	3	2	1	4	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:197665493C>T	uc003fyo.2	-	4	587	c.441G>A	c.(439-441)CAG>CAA	p.Q147Q	IQCG_uc003fyn.2_Silent_p.Q49Q|IQCG_uc003fyp.2_Silent_p.Q147Q|IQCG_uc003fyq.3_Silent_p.Q147Q	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	147											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		AGACAAGATCCTGCATTTTGT	0.433													120	654					0	0	0	0	T	197665493	T	T	197665493	2	4	58	1	0	0	0	0	0	0	0	1	7849	680	24	4		4	IQCG	3	197665493	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1535614	197665493	356937	150	11535											
ZNF595	152687	broad.mit.edu	37	chr4	59410	59410	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagcagaatttgtatagaGatgtgatgttggagaactac	13	11	11	6	0	0	4	0	1	0	3	0	6	0	4	1	1	3	3	1	1	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:59410G>T	uc003fzv.1	+	2	247	c.91G>T	c.(91-93)GAT>TAT	p.D31Y	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Missense_Mutation_p.D31Y|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	31					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TTTGTATAGAGATGTGATGTT	0.423													37	831					5.71845e-15	7.71142e-15	1	0	T	59410	T	T	59410	3	4	58	1	0	0	0	0	1	0	0	0	18092	942	33	2	97	2	ZNF595	4	59410	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08		59410	191094866	151	11536											
ZFYVE28	57732	broad.mit.edu	37	chr4	2306180	2306180	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggcacttgtcggaagtGggggctttgggctcccgccc	4	8	17	12	2	0	0	0	0	0	0	2	1	1	1	2	6	0	4	2	6	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:2306180G>T	uc003gex.1	-	8	2206	c.1887C>A	c.(1885-1887)CCC>CCA	p.P629P	ZFYVE28_uc011bvk.1_Silent_p.P559P|ZFYVE28_uc011bvl.1_Silent_p.P599P|ZFYVE28_uc003gew.1_Silent_p.P515P	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	629					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						TGTCGGAAGTGGGGGCTTTGG	0.667													36	71					6.04917e-29	9.51383e-29	1	0	T	2306180	T	T	2306180	2	4	58	1	0	0	0	0	0	0	0	1	17737	1335	47	4		4	ZFYVE28	4	2306180	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2246770	2306180	188848096	152	11537											
YIPF7	285525	broad.mit.edu	37	chr4	44626780	44626780	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cactcatgccatacacataaCcaaactgaacttttcctgcc	13	10	3	15	0	1	1	1	1	0	0	2	1	2	1	4	0	6	0	4	0	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:44626780C>G	uc010ifx.1	-	5	535	c.518G>C	c.(517-519)GGT>GCT	p.G173A		NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	173	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0						ATACACATAACCAAACTGAAC	0.478													4	3					0	0	0	0	G	44626780	G	G	44626780	3	3	58	1	0	0	0	0	1	0	0	0	17551	507	18	4	332	4	YIPF7	4	44626780	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	42320600	44626780	146527496	153	11538											
NFXL1	152518	broad.mit.edu	37	chr4	47877297	47877297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccttcctcacaatgaaggCattctgggccagcctgaaaa	12	8	8	13	0	2	2	1	2	1	0	3	2	3	2	4	2	1	1	4	2	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:47877297C>T	uc010igh.2	-	18	2270	c.2093G>A	c.(2092-2094)TGC>TAC	p.C698Y	NFXL1_uc003gxo.2_Missense_Mutation_p.C23Y|NFXL1_uc003gxp.2_Missense_Mutation_p.C698Y|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Missense_Mutation_p.C698Y	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	698	NF-X1-type 8.					integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						ACAATGAAGGCATTCTGGGCC	0.428													12	75					0	0	0	0	T	47877297	T	T	47877297	3	4	58	1	0	0	0	0	1	0	0	0	10442	710	25	4	666	4	NFXL1	4	47877297	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3250517	47877297	143276979	154	11539											
SPATA18	132671	broad.mit.edu	37	chr4	52917908	52917908	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagactggtctcaaacgaaaCtttacgaacgttgcaggaaa	16	8	9	8	3	1	1	1	0	1	1	2	4	1	2	0	2	5	2	0	2	6	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:52917908C>G	uc003gzl.2	+	1	316	c.38C>G	c.(37-39)ACT>AGT	p.T13S	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.T13S|SPATA18_uc003gzk.1_Missense_Mutation_p.T13S	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	13					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCAAACGAAACTTTACGAACG	0.567													40	236					0	0	0	0	G	52917908	G	G	52917908	3	3	58	1	0	0	0	0	1	0	0	0	15069	565	20	4	40	4	SPATA18	4	52917908	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5040611	52917908	138236368	155	11540											
KDR	3791	broad.mit.edu	37	chr4	55968085	55968085	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttctattatgaaaaatgcctCcacttttgcacagccaagaa	14	12	5	10	0	1	2	0	1	1	1	2	2	2	2	3	0	3	1	3	0	6	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:55968085C>T	uc003has.2	-	15	2547	c.2245G>A	c.(2245-2247)GAG>AAG	p.E749K	KDR_uc003hat.1_Missense_Mutation_p.E749K	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	749	Ig-like C2-type 7.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AAAAATGCCTCCACTTTTGCA	0.333			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			77	80					0	0	0	0	T	55968085	T	T	55968085	3	4	58	1	0	0	0	0	1	0	0	0	8178	864	30	2	1889	2	KDR	4	55968085	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3050177	55968085	135186191	156	11541											
PROL1	58503	broad.mit.edu	37	chr4	71275727	71275727	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaagttacgacttccaacCaaactatattaagcagccca	15	9	4	13	1	0	0	0	0	0	0	2	1	2	0	4	0	5	2	4	0	7	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:71275727C>T	uc003hfi.2	+	3	856	c.682C>T	c.(682-684)CAA>TAA	p.Q228*		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	228	Thr-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				GACTTCCAACCAAACTATATT	0.408													26	68					0	0	0	0	T	71275727	T	T	71275727	4	4	58	1	0	0	0	0	0	1	0	0	12616	595	21	4	688	4	PROL1	4	71275727	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	15307642	71275727	119878549	157	11542											
ANKRD17	26057	broad.mit.edu	37	chr4	73968234	73968234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcttttttctcttttcgcagCcaaagccagcctccgacttt	6	16	5	14	2	2	0	0	0	2	0	5	1	3	0	4	0	3	1	4	0	1	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:73968234C>T	uc003hgp.2	-	25	4549	c.4432G>A	c.(4432-4434)GCT>ACT	p.A1478T	ANKRD17_uc003hgo.2_Missense_Mutation_p.A1365T|ANKRD17_uc003hgq.2_Missense_Mutation_p.A1227T|ANKRD17_uc003hgr.2_Missense_Mutation_p.A1477T	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1478	Potential.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			cttttcGCAGCCAAAGCCAGC	0.264													11	41					0	0	0	0	T	73968234	T	T	73968234	3	4	58	1	0	0	0	0	1	0	0	0	646	739	26	4	3419	4	ANKRD17	4	73968234	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2692507	73968234	117186042	158	11543											
NUP54	53371	broad.mit.edu	37	chr4	77053715	77053715	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagctgtttgatctgtgcagGagaaagttctgttctagtca	10	14	11	6	0	4	2	1	1	3	1	4	3	4	2	0	1	2	5	0	1	3	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:77053715G>T	uc003hjs.2	-	6	996	c.868C>A	c.(868-870)CCT>ACT	p.P290T	NUP54_uc010ije.2_Missense_Mutation_p.P8T|NUP54_uc011cbs.1_Missense_Mutation_p.P110T|NUP54_uc011cbt.1_Missense_Mutation_p.P242T|NUP54_uc003hjt.2_Missense_Mutation_p.P110T	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	290	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2						ATCTGTGCAGGAGAAAGTTCT	0.383													9	224					1.61879e-10	2.02647e-10	1	0	T	77053715	T	T	77053715	3	4	58	1	0	0	0	0	1	0	0	0	10821	1174	41	2	683	2	NUP54	4	77053715	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3085481	77053715	114100561	159	11544											
CCDC158	339965	broad.mit.edu	37	chr4	77283402	77283402	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	attcaccagcttcaccttttCcagctccaagtcactcactc	9	12	3	17	0	4	0	4	0	0	0	7	0	6	0	4	0	2	2	4	0	1	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:77283402C>A	uc003hkb.3	-	12	2050	c.1897G>T	c.(1897-1899)GAA>TAA	p.E633*		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	633	Potential.									skin(3)|ovary(2)|pancreas(1)	6						TTCACCTTTTCCAGCTCCAAG	0.408													7	239					0.00448238	0.00464612	1	0	A	77283402	A	A	77283402	4	1	58	1	0	0	0	0	0	1	0	0	2803	864	30	2	1496	2	CCDC158	4	77283402	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	229687	77283402	113870874	160	11545											
ANXA3	306	broad.mit.edu	37	chr4	79500196	79500196	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaggaactgatgagaaaaTgctcatcagcattctgactg	13	12	9	7	0	3	3	2	3	1	1	3	5	3	4	0	1	3	2	0	1	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:79500196T>C	uc003hld.2	+	4	429	c.119T>C	c.(118-120)ATG>ACG	p.M40T	ANXA3_uc003hle.2_Missense_Mutation_p.M1T|ANXA3_uc010ijk.2_Missense_Mutation_p.M1T	NM_005139	NP_005130	P12429	ANXA3_HUMAN	annexin A3	40	Annexin 1.				defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity				0						GATGAGAAAATGCTCATCAGC	0.368													17	30					0	0	0	0	C	79500196	C	C	79500196	3	2	58	1	0	0	0	0	1	0	0	0	719	1464	51	5	129	5	ANXA3	4	79500196	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	2216794	79500196	111654080	161	11546											
WDFY3	23001	broad.mit.edu	37	chr4	85600085	85600085	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagttaccaggtttcaatctGctgtaattccgcacctcaat	11	13	6	11	1	3	0	2	0	1	0	4	0	4	0	3	1	2	5	3	1	5	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:85600085G>A	uc003hpd.2	-	65	10542	c.10134C>T	c.(10132-10134)AGC>AGT	p.S3378S	WDFY3_uc003hpc.2_Silent_p.S133S	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	3378						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GTTTCAATCTGCTGTAATTCC	0.517													40	89					0	0	0	0	A	85600085	A	A	85600085	2	1	58	1	0	0	0	0	0	0	0	1	17338	1310	46	4		4	WDFY3	4	85600085	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6099889	85600085	105554191	162	11547											
DMP1	1758	broad.mit.edu	37	chr4	88583240	88583240	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggaggagatgataaagatGacgatgaagatgacagtgga	18	6	15	2	1	0	7	0	4	0	3	0	11	0	9	0	3	0	0	0	3	4	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:88583240G>A	uc003hqv.2	+	6	414	c.310G>A	c.(310-312)GAC>AAC	p.D104N	DMP1_uc003hqw.2_Missense_Mutation_p.D88N	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	104					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		TGATAAAGATGACGATGAAGA	0.502													8	27					0	0	0	0	A	88583240	A	A	88583240	3	1	58	1	0	0	0	0	1	0	0	0	4605	1290	45	2	328	2	DMP1	4	88583240	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2983155	88583240	102571036	163	11548											
CENPE	1062	broad.mit.edu	37	chr4	104062227	104062227	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgacatctttttttaacgtaAtaagttgatgttcatttgcc	10	19	6	6	1	2	2	1	2	1	0	2	2	2	2	1	0	2	3	1	0	3	9			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:104062227A>G	uc003hxb.1	-	36	5588	c.5498T>C	c.(5497-5499)ATT>ACT	p.I1833T	CENPE_uc003hxc.1_Missense_Mutation_p.I1808T|CENPE_uc003hxd.1_5'Flank	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1833	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTTTAACGTAATAAGTTGATG	0.279													9	31					0	0	0	0	G	104062227	G	G	104062227	3	3	58	1	0	0	0	0	1	0	0	0	3245	101	4	5	2663	5	CENPE	4	104062227	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	15478987	104062227	87092049	164	11549											
ENPEP	2028	broad.mit.edu	37	chr4	111397696	111397696	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgtgggcttgaccagatcGtgtgactccagcggggacgg	6	7	17	11	4	0	3	0	2	0	1	2	4	1	4	3	4	1	1	3	4	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:111397696G>A	uc003iab.3	+	1	468	c.126G>A	c.(124-126)TCG>TCA	p.S42S		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	42	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TGACCAGATCGTGTGACTCCA	0.612													9	156					0	0	0	0	A	111397696	A	A	111397696	2	1	58	1	0	0	0	0	0	0	0	1	5152	1132	40	1		1	ENPEP	4	111397696	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	7335469	111397696	79756580	165	11550											
PRDM5	11107	broad.mit.edu	37	chr4	121828688	121828688	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaggcattctcttctctcCagcaaagggtccgaactttt	8	14	7	12	1	3	0	1	0	2	0	7	1	5	0	2	2	2	2	2	2	2	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:121828688C>A	uc003idn.2	-	2	368	c.118G>T	c.(118-120)GGA>TGA	p.G40*	PRDM5_uc003ido.2_Nonsense_Mutation_p.G40*|PRDM5_uc010ine.2_Nonsense_Mutation_p.G40*|PRDM5_uc010inf.2_Nonsense_Mutation_p.G40*|PRDM5_uc003idp.1_Nonsense_Mutation_p.G40*	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	40	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						CTCTTCTCTCCAGCAAAGGGT	0.328													45	114					3.50607e-19	5.0372e-19	1	0	A	121828688	A	A	121828688	4	1	58	1	0	0	0	0	0	1	0	0	12522	603	21	4	1834	4	PRDM5	4	121828688	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	10430992	121828688	69325588	166	11551											
DCHS2	54798	broad.mit.edu	37	chr4	155226280	155226280	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacttcttgaatttctctGtcaagtatggtggttgtcac	9	16	9	7	0	4	2	2	1	2	1	5	2	4	2	0	2	0	2	0	2	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:155226280G>T	uc003inw.2	-	16	3999	c.3999C>A	c.(3997-3999)GAC>GAA	p.D1333E		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1333	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAATTTCTCTGTCAAGTATGG	0.338													8	50					2.17888e-05	2.35901e-05	1	0	T	155226280	T	T	155226280	3	4	58	1	0	0	0	0	1	0	0	0	4305	1368	48	4	4791	4	DCHS2	4	155226280	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	33397592	155226280	35927996	167	11552											
TLL1	7092	broad.mit.edu	37	chr4	166910618	166910618	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attgaccttacgcagaacccCtttggaaaccttggacatac	12	10	7	12	1	0	2	0	1	0	1	0	4	0	4	4	2	4	1	4	2	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:166910618C>A	uc003irh.1	+	2	902	c.255C>A	c.(253-255)CCC>CCA	p.P85P	TLL1_uc011cjn.1_Silent_p.P85P|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	85					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CGCAGAACCCCTTTGGAAACC	0.328													46	131					1.07234e-20	1.57725e-20	1	0	A	166910618	A	A	166910618	2	1	58	1	0	0	0	0	0	0	0	1	16011	668	24	4		4	TLL1	4	166910618	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	11684338	166910618	24243658	168	11553											
GALNTL6	442117	broad.mit.edu	37	chr4	173269706	173269706	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtatctggaaaggctgcCaaacaccagcatcattatcc	13	9	8	11	0	2	0	1	0	1	0	3	2	3	1	3	2	3	3	3	2	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:173269706C>A	uc003isv.2	+	5	1155	c.419C>A	c.(418-420)CCA>CAA	p.P140Q		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	140	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GAAAGGCTGCCAAACACCAGC	0.403													40	105					9.14704e-12	1.17976e-11	1	0	A	173269706	A	A	173269706	3	1	58	1	0	0	0	0	1	0	0	0	6260	594	21	4	433	4	GALNTL6	4	173269706	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	6359088	173269706	17884570	169	11554											
LRP2BP	55805	broad.mit.edu	37	chr4	186295607	186295607	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attttcttcatatagtccacCcctttctccttcgacaaaag	10	15	3	13	1	3	0	1	0	2	0	6	1	4	0	4	0	0	0	4	0	4	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:186295607C>T	uc003ixj.1	-	4	1151	c.339G>A	c.(337-339)GGG>GGA	p.G113G	LRP2BP_uc003ixk.1_Silent_p.G87G|LRP2BP_uc011ckr.1_Silent_p.G113G	NM_018409	NP_060879	Q9P2M1	LR2BP_HUMAN	LRP2 binding protein	113	Sel1-like 1.					cytoplasm	protein binding				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)		TATAGTCCACCCCTTTCTCCT	0.393													34	77					0	0	0	0	T	186295607	T	T	186295607	2	4	58	1	0	0	0	0	0	0	0	1	9007	610	22	4		4	LRP2BP	4	186295607	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	13025901	186295607	4858669	170	11555											
IRX1	79192	broad.mit.edu	37	chr5	3600253	3600253	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcctgggcgttggcgctccCcacgccgcgccccatggccc	2	7	12	20	5	0	0	0	0	0	0	2	0	2	0	7	3	0	2	7	3	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:3600253C>T	uc003jde.2	+	2	1243	c.1191C>T	c.(1189-1191)CCC>CCT	p.P397P		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	397						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						TTGGCGCTCCCCACGCCGCGC	0.667													11	42					0	0	0	0	T	3600253	T	T	3600253	2	4	58	1	0	0	0	0	0	0	0	1	7882	610	22	4		4	IRX1	5	3600253	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08		3600253	177315007	171	11556											
ADCY2	108	broad.mit.edu	37	chr5	7709444	7709444	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggggggcagccaagccctttGcacacctacatcacagggac	10	5	12	14	0	1	0	1	0	0	0	1	1	1	1	3	4	4	2	3	4	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:7709444G>T	uc003jdz.1	+	10	1589	c.1522G>T	c.(1522-1524)GCA>TCA	p.A508S	ADCY2_uc011cmo.1_Missense_Mutation_p.A328S	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	508	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CAAGCCCTTTGCACACCTACA	0.602													8	40					5.18039e-06	5.70849e-06	1	0	T	7709444	T	T	7709444	3	4	58	1	0	0	0	0	1	0	0	0	294	1319	46	4	1560	4	ADCY2	5	7709444	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	4109191	7709444	173205816	172	11557											
ADCY2	108	broad.mit.edu	37	chr5	7826861	7826861	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagacgagcctcgtcctgcaGaccctcggatacacgtgcac	9	6	11	15	4	0	2	0	0	0	2	3	5	1	3	3	1	4	2	3	1	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:7826861G>T	uc003jdz.1	+	25	3220	c.3153G>T	c.(3151-3153)CAG>CAT	p.Q1051H	ADCY2_uc011cmo.1_Missense_Mutation_p.Q871H|ADCY2_uc010itm.1_Missense_Mutation_p.Q247H	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	1051	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TCGTCCTGCAGACCCTCGGAT	0.433													23	105					4.54149e-19	6.49738e-19	1	0	T	7826861	T	T	7826861	3	4	58	1	0	0	0	0	1	0	0	0	294	933	33	2	3251	2	ADCY2	5	7826861	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	117417	7826861	173088399	173	11558											
DNAH5	1767	broad.mit.edu	37	chr5	13692194	13692194	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtagttcaagtccgttcGaactggcttcttatagatgg	10	14	10	7	2	2	1	1	0	1	1	4	2	3	1	1	2	1	4	1	2	6	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:13692194G>T	uc003jfd.2	-	79	13816	c.13774C>A	c.(13774-13776)CGA>AGA	p.R4592R	DNAH5_uc003jfc.2_Silent_p.R760R	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4592					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAGTCCGTTCGAACTGGCTTC	0.468									Kartagener_syndrome				15	89					6.31663e-08	7.29089e-08	1	0	T	13692194	T	T	13692194	2	4	58	1	0	0	0	0	0	0	0	1	4626	1066	37	3		3	DNAH5	5	13692194	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5865333	13692194	167223066	174	11559											
DNAH5	1767	broad.mit.edu	37	chr5	13876810	13876810	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacctttttggtggagttgaTaattgtgctaagcacagaaa	12	14	10	5	0	0	2	0	1	0	1	0	3	0	3	1	2	3	3	1	2	4	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:13876810T>A	uc003jfd.2	-	22	3421	c.3379A>T	c.(3379-3381)ATC>TTC	p.I1127F		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1127	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GTGGAGTTGATAATTGTGCTA	0.378									Kartagener_syndrome				17	82					0	0	0	0	A	13876810	A	A	13876810	3	1	58	1	0	0	0	0	1	0	0	0	4626	1406	49	5	10727	5	DNAH5	5	13876810	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	184616	13876810	167038450	175	11560											
PRDM9	56979	broad.mit.edu	37	chr5	23524604	23524604	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actgggcatcaagtggggcaGcaagtggaagaaagagctca	14	5	15	7	0	2	2	2	0	0	2	2	3	2	3	0	4	2	4	0	4	4	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:23524604G>T	uc003jgo.2	+	10	1294	c.1112G>T	c.(1111-1113)AGC>ATC	p.S371I		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	371					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AAGTGGGGCAGCAAGTGGAAG	0.468										HNSCC(3;0.000094)			26	87					1.7881e-09	2.18617e-09	1	0	T	23524604	T	T	23524604	3	4	58	1	0	0	0	0	1	0	0	0	12525	971	34	4	1146	4	PRDM9	5	23524604	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	9647794	23524604	157390656	176	11561											
PDZD2	23037	broad.mit.edu	37	chr5	32090710	32090710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgggagcctgggccacccaGgtgacgcagcagcaaggttg	8	4	16	13	2	0	1	0	1	0	0	0	2	0	2	4	4	3	4	4	4	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:32090710G>A	uc003jhl.2	+	20	7544	c.7156G>A	c.(7156-7158)GGT>AGT	p.G2386S	PDZD2_uc003jhm.2_Missense_Mutation_p.G2386S	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2386					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GGGCCACCCAGGTGACGCAGC	0.617													14	52					0	0	0	0	A	32090710	A	A	32090710	3	1	58	1	0	0	0	0	1	0	0	0	11755	1000	35	4	7230	4	PDZD2	5	32090710	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	8566106	32090710	148824550	177	11562											
ADAMTS12	81792	broad.mit.edu	37	chr5	33534996	33534996	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattctggaggtctgggtttGtgatcacatagacattggtc	9	14	12	6	0	3	2	1	1	2	1	4	3	3	3	0	4	0	1	0	4	2	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:33534996G>C	uc003jia.1	-	23	4711	c.4548C>G	c.(4546-4548)CAC>CAG	p.H1516Q	ADAMTS12_uc010iuq.1_Missense_Mutation_p.H1431Q	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1516	TSP type-1 8.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GTCTGGGTTTGTGATCACATA	0.493										HNSCC(64;0.19)			35	112					0	0	0	0	C	33534996	C	C	33534996	3	2	58	1	0	0	0	0	1	0	0	0	257	1368	48	4	244	4	ADAMTS12	5	33534996	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1444286	33534996	147380264	178	11563											
ADAMTS12	81792	broad.mit.edu	37	chr5	33577237	33577237	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacatgtgacactgcgaatcCgcactccaccaccacaggaa	13	5	7	16	2	0	1	0	1	0	0	2	3	2	2	4	1	1	1	4	1	2	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:33577237C>G	uc003jia.1	-	19	3057	c.2894G>C	c.(2893-2895)CGG>CCG	p.R965P	ADAMTS12_uc010iuq.1_Missense_Mutation_p.R880P	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	965	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						ACTGCGAATCCGCACTCCACC	0.493										HNSCC(64;0.19)			30	118					0	0	0	0	G	33577237	G	G	33577237	3	3	58	1	0	0	0	0	1	0	0	0	257	652	23	3	1914	3	ADAMTS12	5	33577237	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	42241	33577237	147338023	179	11564											
IL7R	3575	broad.mit.edu	37	chr5	35876247	35876247	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttggaggggatgtgcagagcCccaactgcccatctgaggat	9	8	14	10	0	1	2	0	1	1	1	1	5	1	5	3	4	4	1	3	4	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:35876247C>T	uc003jjs.2	+	8	1128	c.1039C>T	c.(1039-1041)CCC>TCC	p.P347S	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	347	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TGTGCAGAGCCCCAACTGCCC	0.502													17	52					0	0	0	0	T	35876247	T	T	35876247	3	4	58	1	0	0	0	0	1	0	0	0	7744	623	22	4	1069	4	IL7R	5	35876247	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2299010	35876247	145039013	180	11565											
C9	735	broad.mit.edu	37	chr5	39308356	39308356	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctaccctctcccctctttaCacaatcatctttattaaatt	10	17	0	14	0	5	0	1	0	4	0	6	0	5	0	3	0	2	0	3	0	6	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:39308356C>T	uc003jlv.3	-	8	1305	c.1216G>A	c.(1216-1218)GTA>ATA	p.V406I		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	406	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CCCCTCTTTACACAATCATCT	0.418													24	94					0	0	0	0	T	39308356	T	T	39308356	3	4	58	1	0	0	0	0	1	0	0	0	2455	478	17	4	479	4	C9	5	39308356	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3432109	39308356	141606904	181	11566											
C7	730	broad.mit.edu	37	chr5	40979897	40979897	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctctgacagtttgcaagatgCatgttctccactgtcagggt	8	13	10	10	0	3	2	1	1	2	1	4	2	3	2	1	1	2	4	1	1	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:40979897C>T	uc003jmh.2	+	17	2350	c.2236C>T	c.(2236-2238)CAT>TAT	p.H746Y	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	746	Complement control factor I module 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				TTGCAAGATGCATGTTCTCCA	0.453													14	53					0	0	0	0	T	40979897	T	T	40979897	3	4	58	1	0	0	0	0	1	0	0	0	2386	710	25	4	2302	4	C7	5	40979897	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1671541	40979897	139935363	182	11567											
HEATR7B2	133558	broad.mit.edu	37	chr5	41000408	41000408	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taataccccatagagctcctGgaggcccaaaaagggaatgc	14	6	10	11	0	0	1	0	0	0	1	1	3	1	3	4	3	3	1	4	3	6	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:41000408G>A	uc003jmj.3	-	39	4886	c.4396C>T	c.(4396-4398)CAG>TAG	p.Q1466*	HEATR7B2_uc003jmi.3_Nonsense_Mutation_p.Q1021*	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1466							binding			ovary(6)|central_nervous_system(2)	8						TAGAGCTCCTGGAGGCCCAAA	0.488													13	56					0	0	0	0	A	41000408	A	A	41000408	4	1	58	1	0	0	0	0	0	1	0	0	7074	1357	47	4	377	4	HEATR7B2	5	41000408	Nonsense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	20511	41000408	139914852	183	11568											
GFM2	84340	broad.mit.edu	37	chr5	74017519	74017519	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggttgagcagtgtattttgAtcttgaggattcatggcttg	7	16	13	5	1	2	3	1	3	1	0	2	4	2	4	0	3	1	4	0	3	1	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:74017519A>G	uc003kdh.1	-	21	2605	c.2301T>C	c.(2299-2301)GAT>GAC	p.D767D	GFM2_uc003kdi.1_Silent_p.D720D|GFM2_uc010izj.1_Silent_p.D799D|GFM2_uc010izk.1_RNA	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	767					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		GTGTATTTTGATCTTGAGGAT	0.383													25	72					0	0	0	0	G	74017519	G	G	74017519	2	3	58	1	0	0	0	0	0	0	0	1	6379	330	12	5		5	GFM2	5	74017519	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	33017111	74017519	106897741	184	11569											
IQGAP2	10788	broad.mit.edu	37	chr5	75906917	75906917	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggactttagaaactttgcTcctacctactgcgaatatta	12	13	7	9	1	0	1	0	0	0	1	1	4	1	2	2	1	5	1	2	1	7	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:75906917T>C	uc003kek.2	+	13	1652	c.1430T>C	c.(1429-1431)CTC>CCC	p.L477P	IQGAP2_uc010izv.2_Missense_Mutation_p.L30P|IQGAP2_uc011csv.1_Missense_Mutation_p.L30P|IQGAP2_uc003kel.2_Missense_Mutation_p.L30P	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	477					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GAAACTTTGCTCCTACCTACT	0.408													41	86					0	0	0	0	C	75906917	C	C	75906917	3	2	58	1	0	0	0	0	1	0	0	0	7854	1551	54	5	1480	5	IQGAP2	5	75906917	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1889398	75906917	105008343	185	11570											
GPR98	84059	broad.mit.edu	37	chr5	89933675	89933675	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taatggctctgttttgttttTatctgggcaaagtgacacaa	10	16	9	6	0	2	1	0	1	2	0	2	1	2	1	0	2	0	4	0	2	4	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:89933675T>C	uc003kju.2	+	11	2246	c.2150T>C	c.(2149-2151)TTA>TCA	p.L717S	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	717	Calx-beta 5.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTTTTGTTTTTATCTGGGCAA	0.423													29	52					0	0	0	0	C	89933675	C	C	89933675	3	2	58	1	0	0	0	0	1	0	0	0	6760	1764	61	5	2192	5	GPR98	5	89933675	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	14026758	89933675	90981585	186	11571											
PAM	5066	broad.mit.edu	37	chr5	102286460	102286460	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atccagttgatgtaagttttGgtgacctactggctgcaaga	10	13	11	7	0	0	3	0	2	0	1	1	3	1	3	2	2	2	5	2	2	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:102286460G>T	uc003knw.2	+	11	1214	c.841G>T	c.(841-843)GGT>TGT	p.G281C	PAM_uc003kns.2_Missense_Mutation_p.G281C|PAM_uc003knt.2_Missense_Mutation_p.G281C|PAM_uc003knu.2_Missense_Mutation_p.G281C|PAM_uc003knv.2_Missense_Mutation_p.G281C|PAM_uc011cuz.1_Missense_Mutation_p.G184C	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	281	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	TGTAAGTTTTGGTGACCTACT	0.368													28	56					3.67414e-24	5.61007e-24	1	0	T	102286460	T	T	102286460	3	4	58	1	0	0	0	0	1	0	0	0	11466	1348	47	4	883	4	PAM	5	102286460	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	12352785	102286460	78628800	187	11572											
PPIP5K2	23262	broad.mit.edu	37	chr5	102474116	102474116	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatatagtattcttcaagctGaaggtattttacttcctcgt	10	18	6	7	1	2	1	1	1	1	0	4	1	3	1	1	1	2	3	1	1	8	10			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:102474116G>A	uc003kod.3	+	5	949	c.430G>A	c.(430-432)GAA>AAA	p.E144K	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.E144K|PPIP5K2_uc010jbo.1_Missense_Mutation_p.E66K	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	144					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						TCTTCAAGCTGAAGGTATTTT	0.338													16	47					0	0	0	0	A	102474116	A	A	102474116	3	1	58	1	0	0	0	0	1	0	0	0	12393	1291	45	2	444	2	PPIP5K2	5	102474116	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	187656	102474116	78441144	188	11573											
MCC	4163	broad.mit.edu	37	chr5	112384928	112384928	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggcctcccgcgtgctcagCttcagctccagggccttctt	3	11	11	16	2	3	0	2	0	1	0	5	0	5	0	4	2	3	3	4	2	0	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:112384928C>A	uc003kqj.3	-	14	2477	c.1947G>T	c.(1945-1947)AAG>AAT	p.K649N	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Missense_Mutation_p.K839N|MCC_uc011cwb.1_Missense_Mutation_p.K649N	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	649					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GCGTGCTCAGCTTCAGCTCCA	0.597													14	29					4.93089e-13	6.47001e-13	1	0	A	112384928	A	A	112384928	3	1	58	1	0	0	0	0	1	0	0	0	9426	796	28	4	558	4	MCC	5	112384928	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	9910812	112384928	68530332	189	11574											
SLC12A2	6558	broad.mit.edu	37	chr5	127510346	127510348	+	In_Frame_Del	DEL	ATT	-	-																															aaccactcagtgaaaaaccaAttacacacaaaggtaatttt																								rs149957408		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:127510346_127510348delATT	uc003kus.2	+	20	3081_3083	c.2917_2919delATT	c.(2917-2919)ATTdel	p.I973del	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_In_Frame_Del_p.I973del	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	973	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGAAAAACCAATTACACACAAAG	0.271													---	---	---								-	127510348	-	-	127510346	7	5	58	1	0	1	0	1	0	0	0	0	14448	101	4	0	2995	0	SLC12A2	5	127510346	In_Frame_Del	DEL	ATT	TCGA-CN-5360-01A-01D-1434-08	15125418	127510346	53404914	190	11575											
PCDHA2	56146	broad.mit.edu	37	chr5	140176058	140176058	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggcgggtgggcgagcgcgcGttgtcgagctacgtttcggt	3	9	19	10	9	0	0	0	0	0	0	2	2	0	0	0	4	3	3	0	4	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140176058G>T	uc003lhd.2	+	1	1615	c.1509G>T	c.(1507-1509)GCG>GCT	p.A503A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.A503A|PCDHA2_uc011czy.1_Silent_p.A503A	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGCGCGCGTTGTCGAGCT	0.677													17	33					5.35267e-07	6.05509e-07	1	0	T	140176058	T	T	140176058	2	4	58	1	0	0	0	0	0	0	0	1	11578	1132	40	3		3	PCDHA2	5	140176058	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	12665712	140176058	40739202	191	11576											
PCDHA3	56145	broad.mit.edu	37	chr5	140181115	140181115	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctggaggtgatcgtggaCaggccgctgcaggttttcca	7	9	14	11	2	0	1	0	1	0	0	2	3	1	3	3	5	1	3	3	5	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140181115C>A	uc003lhf.2	+	1	333	c.333C>A	c.(331-333)GAC>GAA	p.D111E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.D111E	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	111	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATCGTGGACAGGCCGCTGC	0.507													55	115					1.11015e-26	1.72212e-26	1	0	A	140181115	A	A	140181115	3	1	58	1	0	0	0	0	1	0	0	0	11579	477	17	4	335	4	PCDHA3	5	140181115	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5057	140181115	40734145	192	11577											
PCDHA7	56141	broad.mit.edu	37	chr5	140215406	140215406	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acatcttcactgtgtcggcgGgggacgcggacgcgcagaag	8	6	16	11	6	2	1	1	0	1	1	3	3	2	3	0	4	0	1	0	4	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140215406G>T	uc003lhq.2	+	1	1438	c.1438G>T	c.(1438-1440)GGG>TGG	p.G480W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.G480W	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	480	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGTCGGCGGGGGACGCGGA	0.672													22	26					7.92952e-12	1.02467e-11	1	0	T	140215406	T	T	140215406	3	4	58	1	0	0	0	0	1	0	0	0	11583	1232	43	4	1440	4	PCDHA7	5	140215406	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	34291	140215406	40699854	193	11578											
PCDHA9	9752	broad.mit.edu	37	chr5	140229949	140229949	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcgagcatcccgttccgCgtggggctgtacacgggcga	6	6	16	13	7	0	0	0	0	0	0	2	2	2	0	2	3	3	4	2	3	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140229949C>T	uc003lhu.2	+	1	2593	c.1869C>T	c.(1867-1869)CGC>CGT	p.R623R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.R623R	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	623	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCGTTCCGCGTGGGGCTGT	0.667													18	50					0	0	0	0	T	140229949	T	T	140229949	2	4	58	1	0	0	0	0	0	0	0	1	11585	755	27	1		1	PCDHA9	5	140229949	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	14543	140229949	40685311	194	11579											
PCDHA10	56139	broad.mit.edu	37	chr5	140236300	140236300	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggcaaacctgaatttaccGgatctgtttctctgctgatc	9	13	9	10	1	2	2	0	2	2	0	4	4	2	3	2	2	3	3	2	2	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140236300G>T	uc003lhx.2	+	1	667	c.667G>T	c.(667-669)GGA>TGA	p.G223*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Nonsense_Mutation_p.G223*|PCDHA10_uc011dad.1_Nonsense_Mutation_p.G223*	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	223	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAATTTACCGGATCTGTTTC	0.433													60	113					6.20203e-27	9.66495e-27	1	0	T	140236300	T	T	140236300	4	4	58	1	0	0	0	0	0	1	0	0	11574	1117	39	3	669	3	PCDHA10	5	140236300	Nonsense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6351	140236300	40678960	195	11580											
PCDHA11	56138	broad.mit.edu	37	chr5	140250827	140250827	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccagcctcctggtactcacGctgctgctgtatacggcgct	5	11	10	15	3	1	0	1	0	0	0	3	0	3	0	3	2	5	6	3	2	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140250827G>T	uc003lia.2	+	1	2997	c.2139G>T	c.(2137-2139)ACG>ACT	p.T713T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.T713T	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	713	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTACTCACGCTGCTGCTGT	0.687													12	30					1.08611e-07	1.24518e-07	1	0	T	140250827	T	T	140250827	2	4	58	1	0	0	0	0	0	0	0	1	11575	1074	38	3		3	PCDHA11	5	140250827	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	14527	140250827	40664433	196	11581											
PCDHB7	56129	broad.mit.edu	37	chr5	140553967	140553967	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggccacctgtttgccctcagGtccctggactacgaggccct	5	9	11	16	1	1	0	1	0	0	0	2	2	2	1	5	4	2	1	5	4	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140553967G>T	uc003lit.2	+	1	1725	c.1551G>T	c.(1549-1551)AGG>AGT	p.R517S		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	517	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTGCCCTCAGGTCCCTGGACT	0.706													28	60					2.4375e-19	3.52428e-19	1	0	T	140553967	T	T	140553967	3	4	58	1	0	0	0	0	1	0	0	0	11601	1252	44	4	1553	4	PCDHB7	5	140553967	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	303140	140553967	40361293	197	11582											
PCDHB10	56126	broad.mit.edu	37	chr5	140573129	140573129	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaagatgtagggttttagTggaagtattggacaccaatg	12	12	13	4	0	0	1	0	0	0	1	0	3	0	3	1	3	1	4	1	3	6	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140573129T>A	uc003lix.2	+	1	1178	c.1004T>A	c.(1003-1005)GTG>GAG	p.V335E		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	335	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGGTTTTAGTGGAAGTATTG	0.408													41	80					0	0	0	0	A	140573129	A	A	140573129	3	1	58	1	0	0	0	0	1	0	0	0	11589	1696	59	5	1006	5	PCDHB10	5	140573129	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	19162	140573129	40342131	198	11583											
PCDHGA8	9708	broad.mit.edu	37	chr5	140772327	140772327	+	Translation_Start_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctgcggcaagaaactaaatAagacccatttatgcacagtg	15	8	9	9	1	0	2	0	0	0	2	0	2	0	2	1	1	3	3	1	1	6	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140772327A>G	uc003lkd.1	+	1	845	c.-53A>G	c.(-55--51)ATAAG>ATGAG		PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Translation_Start_Site	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAACTAAATAAGACCCATTT	0.527													2	1					0	0	0	0	G	140772327	G	G	140772327	1	3	58	1	0	0	0	0	0	0	0	0	11614	377	13	5		5	PCDHGA8	5	140772327	Translation_Start_Site	SNP	A	TCGA-CN-5360-01A-01D-1434-08	199198	140772327	40142933	199	11584											
SLC36A2	153201	broad.mit.edu	37	chr5	150712872	150712872	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	accagtggcaaccggctgggGtctgggatttcctaaagaag	10	8	14	9	1	1	1	0	0	1	1	2	2	2	2	3	5	1	2	3	5	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:150712872G>A	uc003lty.2	-	7	886	c.756C>T	c.(754-756)GAC>GAT	p.D252D	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Silent_p.D54D|SLC36A2_uc010jhv.2_Silent_p.D252D	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	252	Extracellular (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCGGCTGGGGTCTGGGATTT	0.438													25	56					0	0	0	0	A	150712872	A	A	150712872	2	1	58	1	0	0	0	0	0	0	0	1	14658	1252	44	4		4	SLC36A2	5	150712872	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	9940545	150712872	30202388	200	11585											
FOXI1	2299	broad.mit.edu	37	chr5	169535593	169535593	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caccagtggtgtcctctaccCcagggagggcaccgaggtct	7	7	13	14	1	2	0	0	0	2	0	3	2	3	1	5	4	1	1	5	4	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:169535593C>A	uc003mai.3	+	2	1160	c.1115C>A	c.(1114-1116)CCC>CAC	p.P372H	FOXI1_uc003maj.3_Missense_Mutation_p.P277H	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	372					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCCTCTACCCCAGGGAGGGC	0.572									Pendred_syndrome				24	75					7.38237e-10	9.12412e-10	1	0	A	169535593	A	A	169535593	3	1	58	1	0	0	0	0	1	0	0	0	6043	623	22	4	1121	4	FOXI1	5	169535593	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	18822721	169535593	11379667	201	11586											
RANBP17	64901	broad.mit.edu	37	chr5	170720913	170720913	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtcctcatgaacaccatTgtctttgaagactgtcggaa	10	13	8	10	1	3	3	1	2	2	1	5	4	4	4	2	1	1	0	2	1	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:170720913T>A	uc003mba.2	+	26	2986	c.2970T>A	c.(2968-2970)ATT>ATA	p.I990I	RANBP17_uc003mbb.2_Silent_p.I315I|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	990					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGAACACCATTGTCTTTGAAG	0.488			T	TRD@	ALL								61	137					0	0	0	0	A	170720913	A	A	170720913	2	1	58	1	0	0	0	0	0	0	0	1	13092	1800	63	5		5	RANBP17	5	170720913	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1185320	170720913	10194347	202	11587											
HK3	3101	broad.mit.edu	37	chr5	176309035	176309035	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agccatcgtccccaaaggcgCcccactccatgttgatgcac	9	7	8	17	2	0	1	0	1	0	0	3	1	2	1	6	1	2	2	6	1	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:176309035C>T	uc003mfa.2	-	16	2239	c.2147G>A	c.(2146-2148)GGC>GAC	p.G716D	HK3_uc003mez.2_Missense_Mutation_p.G272D	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	716	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCAAAGGCGCCCCACTCCAT	0.632													23	56					0	0	0	0	T	176309035	T	T	176309035	3	4	58	1	0	0	0	0	1	0	0	0	7231	739	26	4	640	4	HK3	5	176309035	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5588122	176309035	4606225	203	11588											
NSD1	64324	broad.mit.edu	37	chr5	176637631	176637631	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttgttcacaaaccccagtCagattttacaaatgatgctc	12	13	5	11	0	3	2	2	1	1	1	4	2	3	2	2	0	3	2	2	0	3	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:176637631C>G	uc003mfr.3	+	5	2369	c.2231C>G	c.(2230-2232)TCA>TGA	p.S744*	NSD1_uc003mft.3_Nonsense_Mutation_p.S475*|NSD1_uc003mfs.1_Nonsense_Mutation_p.S641*|NSD1_uc011dfx.1_Nonsense_Mutation_p.S392*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	744					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AAACCCCAGTCAGATTTTACA	0.438			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			25	56					0	0	0	0	G	176637631	G	G	176637631	4	3	58	1	0	0	0	0	0	1	0	0	10723	838	29	2	2245	2	NSD1	5	176637631	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	328596	176637631	4277629	204	11589											
CAP2	10486	broad.mit.edu	37	chr6	17539517	17539517	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggtcctgtagcatccacAgtatcagcgttttctgtcct	7	13	9	12	1	2	0	1	0	1	0	5	0	5	0	3	1	2	4	3	1	2	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:17539517A>G	uc003ncb.2	+	8	897	c.654A>G	c.(652-654)ACA>ACG	p.T218T	CAP2_uc010jpk.1_RNA|CAP2_uc011dja.1_Silent_p.T192T|CAP2_uc011djb.1_Silent_p.T154T|CAP2_uc011djc.1_Silent_p.T106T|CAP2_uc011djd.1_Intron	NM_006366	NP_006357	P40123	CAP2_HUMAN	adenylyl cyclase-associated protein 2	218					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			ovary(1)	1	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			TAGCATCCACAGTATCAGCGT	0.567													59	195					0	0	0	0	G	17539517	G	G	17539517	2	3	58	1	0	0	0	0	0	0	0	1	2632	175	7	5		5	CAP2	6	17539517	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08		17539517	153575550	205	11590											
SOX4	6659	broad.mit.edu	37	chr6	21596066	21596066	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctcgaccgggacctggattTtaacttcgagcccggctccg	6	9	12	14	5	0	0	0	0	0	0	3	4	1	2	4	3	2	2	4	3	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:21596066T>G	uc003ndi.2	+	1	2095	c.1301T>G	c.(1300-1302)TTT>TGT	p.F434C		NM_003107	NP_003098	Q06945	SOX4_HUMAN	SRY (sex determining region Y)-box 4	434					canonical Wnt receptor signaling pathway|cardiac ventricle formation|cellular response to glucose stimulus|DNA damage response, detection of DNA damage|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|glial cell development|glial cell proliferation|limb bud formation|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein export from nucleus|negative regulation of protein ubiquitination|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|positive regulation of insulin secretion|positive regulation of N-terminal peptidyl-lysine acetylation|positive regulation of translation|pro-B cell differentiation|protein stabilization|skeletal system development|spinal cord motor neuron differentiation|sympathetic nervous system development|T cell differentiation	mitochondrion|nucleus	core promoter sequence-specific DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity				0	Ovarian(93;0.163)		all cancers(50;0.0751)|Epithelial(50;0.155)			GACCTGGATTTTAACTTCGAG	0.607													10	26					0	0	0	0	G	21596066	G	G	21596066	3	3	58	1	0	0	0	0	1	0	0	0	15017	1841	64	5	1303	5	SOX4	6	21596066	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	4056549	21596066	149519001	206	11591											
FAM65B	9750	broad.mit.edu	37	chr6	24873954	24873954	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggattgttgtttttgtggcCtaaattgtgcattttcttca	6	20	10	5	0	2	0	1	0	1	0	2	1	2	1	1	2	1	3	1	2	2	9			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:24873954C>A	uc003neo.1	-	3	351	c.175G>T	c.(175-177)GGC>TGC	p.G59C	FAM65B_uc011djs.1_Missense_Mutation_p.G88C|FAM65B_uc011dju.1_Missense_Mutation_p.G93C|FAM65B_uc003nep.2_Missense_Mutation_p.G59C|FAM65B_uc011djt.1_Missense_Mutation_p.G59C	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	59	Involved in cell filopodia formation.				cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						TTTTTGTGGCCTAAATTGTGC	0.428													26	107					4.26978e-12	5.52798e-12	1	0	A	24873954	A	A	24873954	3	1	58	1	0	0	0	0	1	0	0	0	5632	681	24	4	3125	4	FAM65B	6	24873954	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3277888	24873954	146241113	207	11592											
SCGN	10590	broad.mit.edu	37	chr6	25665232	25665232	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctttcgccgggaaaaccCactggacagcagcgtggagt	9	7	13	12	3	1	0	0	0	1	0	2	3	1	3	2	3	3	2	2	3	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:25665232C>A	uc003nfb.2	+	4	511	c.308C>A	c.(307-309)CCA>CAA	p.P103Q	SCGN_uc010jpz.2_Missense_Mutation_p.H13N	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	103						extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						CGGGAAAACCCACTGGACAGC	0.493													17	70					4.96729e-08	5.74317e-08	1	0	A	25665232	A	A	25665232	3	1	58	1	0	0	0	0	1	0	0	0	13968	594	21	4	322	4	SCGN	6	25665232	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	791278	25665232	145449835	208	11593											
HIST1H2AH	85235	broad.mit.edu	37	chr6	27115070	27115070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgccagtgtacctggctgcgGtgctggagtacctgaccgct	5	9	14	13	3	0	1	0	1	0	0	0	2	0	2	4	3	4	5	4	3	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:27115070G>A	uc003niz.2	+	1	163	c.163G>A	c.(163-165)GTG>ATG	p.V55M	HIST1H2BK_uc003nix.1_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080596	NP_542163	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	55					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CCTGGCTGCGGTGCTGGAGTA	0.652													26	59					0	0	0	0	A	27115070	A	A	27115070	3	1	58	1	0	0	0	0	1	0	0	0	7173	1261	44	4	165	4	HIST1H2AH	6	27115070	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1449838	27115070	143999997	209	11594											
SCAND3	114821	broad.mit.edu	37	chr6	28539885	28539886	+	Frame_Shift_Ins	INS	-	A	A																															aattttaaagcaatctcagcINSaagctcaggatagtcatttt																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:28539885_28539886insA	uc003nlo.2	-	4	4398_4399	c.3780_3781insT	c.(3778-3783)CTTGCTfs	p.L1260fs		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1260_1261					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						gcaatctcagcaagctcaggat	0													---	---	---								A	28539886	A	A	28539885	7	5	58	1	0	1	1	0	0	0	0	0	13941	710	25	0	200	0	SCAND3	6	28539885	Frame_Shift_Ins	INS	-	TCGA-CN-5360-01A-01D-1434-08	1424815	28539885	142575182	210	11595											
OR2W1	26692	broad.mit.edu	37	chr6	29012793	29012793	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtacattggtgtatgaagctGggaatccaggagagatgcaa	13	9	14	5	0	0	2	0	1	0	1	1	5	1	4	1	3	3	4	1	3	5	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:29012793G>T	uc003nlw.2	-	1	160	c.160C>A	c.(160-162)CAG>AAG	p.Q54K		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GTATGAAGCTGGGAATCCAGG	0.428													38	106					1.836e-18	2.59941e-18	1	0	T	29012793	T	T	29012793	3	4	58	1	0	0	0	0	1	0	0	0	11086	1357	47	4	806	4	OR2W1	6	29012793	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	472908	29012793	142102274	211	11596											
PPP1R11	6992	broad.mit.edu	37	chr6	30035206	30035206	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccatggccgaggcaggggctGggctgagcgagaccgtcact	7	5	17	12	3	1	2	1	1	0	1	1	4	1	2	3	5	1	3	3	5	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:30035206G>A	uc003npb.2	+	1	275	c.19G>A	c.(19-21)GGG>AGG	p.G7R	PPP1R11_uc010jrw.2_RNA|PPP1R11_uc003npc.2_RNA	NM_021959	NP_068778	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor)	7						soluble fraction	protein binding|protein phosphatase inhibitor activity			ovary(1)|lung(1)|skin(1)	3						GGCAGGGGCTGGGCTGAGCGA	0.612													27	100					0	0	0	0	A	30035206	A	A	30035206	3	1	58	1	0	0	0	0	1	0	0	0	12413	1348	47	4	21	4	PPP1R11	6	30035206	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1022413	30035206	141079861	212	11597											
TRIM39	56658	broad.mit.edu	37	chr6	30309588	30309588	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaagactccgggatctccCtgacacaccaaggcgtttca	11	7	9	14	2	2	2	1	1	1	1	4	4	3	3	3	2	0	1	3	2	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:30309588C>T	uc010jrz.2	+	9	1421	c.1109C>T	c.(1108-1110)CCT>CTT	p.P370L	TRIM39_uc003npz.2_Missense_Mutation_p.P340L|TRIM39_uc003nqb.2_Missense_Mutation_p.P340L|TRIM39_uc003nqc.2_Missense_Mutation_p.P340L|TRIM39_uc010jsa.1_Missense_Mutation_p.P340L	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	370	B30.2/SPRY.				apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						CGGGATCTCCCTGACACACCA	0.572													15	40					0	0	0	0	T	30309588	T	T	30309588	3	4	58	1	0	0	0	0	1	0	0	0	16580	681	24	4	1135	4	TRIM39	6	30309588	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	274382	30309588	140805479	213	11598											
CFB	629	broad.mit.edu	37	chr6	31911569	31911569	+	5'Flank	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctggcccagaaagtaaaGatgtccacccatgccaggtg	13	6	11	11	0	0	2	0	0	0	2	1	2	1	2	4	2	2	2	4	2	4	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:31911569G>T	uc003nyj.3	+						C2_uc003nyc.2_Missense_Mutation_p.K359N|C2_uc011doo.1_Missense_Mutation_p.K326N|C2_uc011dop.1_Missense_Mutation_p.K358N|C2_uc003nyf.2_Missense_Mutation_p.K572N|C2_uc010jtk.2_Missense_Mutation_p.K440N|C2_uc011doq.1_Missense_Mutation_p.K543N|C2_uc003nyg.2_Missense_Mutation_p.K349N|CFB_uc011dor.1_Missense_Mutation_p.K419N|C2_uc003nyh.1_Missense_Mutation_p.K223N|CFB_uc011dos.1_5'Flank|CFB_uc003nyi.2_5'Flank	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein						complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						AGAAAGTAAAGATGTCCACCC	0.547													35	118					2.87052e-16	3.92535e-16	1	0	T	31911569	T	T	31911569	1	4	58	0	1	0	0	0	0	0	0	0	3293	933	33	2		2	CFB	6	31911569	5'Flank	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1601981	31911569	139203498	214	11599											
DNAH8	1769	broad.mit.edu	37	chr6	38754683	38754683	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagaacaggcaaagagattGctaaaattggaaagtaaatt	19	8	9	5	0	0	2	0	0	0	2	0	4	0	3	1	2	2	3	1	2	7	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:38754683G>A	uc003ooe.1	+	16	2487	c.1887G>A	c.(1885-1887)TTG>TTA	p.L629L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CAAAGAGATTGCTAAAATTGG	0.308													13	52					0	0	0	0	A	38754683	A	A	38754683	2	1	58	1	0	0	0	0	0	0	0	1	4629	1310	46	4		4	DNAH8	6	38754683	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6843114	38754683	132360384	215	11600											
KIF6	221458	broad.mit.edu	37	chr6	39353414	39353414	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctacctagggctacttgctgTatatgccgctgggtgatttc	6	14	11	10	1	0	1	0	1	0	0	1	1	0	1	2	2	4	4	2	2	5	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:39353414T>C	uc003oot.2	-	16	1940	c.1845A>G	c.(1843-1845)ATA>ATG	p.I615M	KIF6_uc003oos.2_Missense_Mutation_p.I66M|KIF6_uc010jwz.1_Translation_Start_Site|KIF6_uc010jxa.1_Missense_Mutation_p.I406M|KIF6_uc011dua.1_Intron|KIF6_uc010jxb.1_Missense_Mutation_p.I559M	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	615	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						CTACTTGCTGTATATGCCGCT	0.448													15	74					0	0	0	0	C	39353414	C	C	39353414	3	2	58	1	0	0	0	0	1	0	0	0	8347	1628	57	5	631	5	KIF6	6	39353414	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	598731	39353414	131761653	216	11601											
UBR2	23304	broad.mit.edu	37	chr6	42613293	42613293	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agttgagtatcaagcctatgGctcatagtgaattggtaaag	13	12	11	5	0	2	2	2	2	0	0	2	2	2	2	1	2	1	4	1	2	7	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:42613293G>A	uc011dur.1	+	21	2374	c.2374G>A	c.(2374-2376)GCT>ACT	p.A792T	UBR2_uc011dus.1_Missense_Mutation_p.A437T|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	792					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			CAAGCCTATGGCTCATAGTGA	0.373													28	82					0	0	0	0	A	42613293	A	A	42613293	3	1	58	1	0	0	0	0	1	0	0	0	16970	1203	42	4	2602	4	UBR2	6	42613293	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3259879	42613293	128501774	217	11602											
C6orf138	442213	broad.mit.edu	37	chr6	47846286	47846286	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactaacccaataagaaaaGaagtaacattttgcaaaatg	20	8	7	6	0	0	2	0	0	0	2	0	3	0	3	1	1	3	2	1	1	9	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:47846286G>T	uc011dwm.1	-	3	2328	c.2243C>A	c.(2242-2244)TCT>TAT	p.S748Y	C6orf138_uc011dwn.1_Missense_Mutation_p.S512Y	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	765	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						AATAAGAAAAGAAGTAACATT	0.443													12	36					0.000978159	0.00102481	1	0	T	47846286	T	T	47846286	3	4	58	1	0	0	0	0	1	0	0	0	2342	942	33	2	250	2	C6orf138	6	47846286	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5232993	47846286	123268781	218	11603											
PGK2	5232	broad.mit.edu	37	chr6	49754394	49754394	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggaactatgagcgcggtgTgcagtgccaaaagcatcatt	12	9	12	8	2	1	1	1	1	0	0	1	2	1	2	1	2	5	2	1	2	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:49754394T>C	uc003ozu.2	-	1	614	c.507A>G	c.(505-507)GCA>GCG	p.A169A		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	169					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					GAGCGCGGTGTGCAGTGCCAA	0.453													28	73					0	0	0	0	C	49754394	C	C	49754394	2	2	58	1	0	0	0	0	0	0	0	1	11846	1683	59	5		5	PGK2	6	49754394	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1908108	49754394	121360673	219	11604											
PKHD1	5314	broad.mit.edu	37	chr6	51927386	51927386	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagggacaatctgccacctgTaccctggggtggcttcagtc	7	10	12	12	0	2	0	1	0	1	0	3	1	2	1	3	4	2	2	3	4	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:51927386T>A	uc003pah.1	-	14	1325	c.1049A>T	c.(1048-1050)TAC>TTC	p.Y350F	PKHD1_uc003pai.2_Missense_Mutation_p.Y350F	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	350	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTGCCACCTGTACCCTGGGGT	0.483													49	118					0	0	0	0	A	51927386	A	A	51927386	3	1	58	1	0	0	0	0	1	0	0	0	12026	1638	57	5	11430	5	PKHD1	6	51927386	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	2172992	51927386	119187681	220	11605											
ZNF451	26036	broad.mit.edu	37	chr6	57012801	57012801	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatagatacagctgtgctCactgcagaaagccttttcat	11	13	7	10	0	3	2	3	0	0	2	3	2	3	2	1	0	5	3	1	0	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:57012801C>T	uc003pdm.1	+	10	2142	c.1918C>T	c.(1918-1920)CAC>TAC	p.H640Y	ZNF451_uc003pdl.2_Missense_Mutation_p.H640Y|ZNF451_uc003pdn.1_Missense_Mutation_p.H640Y|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.H640Y	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	640	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CAGCTGTGCTCACTGCAGAAA	0.398													31	105					0	0	0	0	T	57012801	T	T	57012801	3	4	58	1	0	0	0	0	1	0	0	0	17989	826	29	2	1956	2	ZNF451	6	57012801	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5085415	57012801	114102266	221	11606											
BAI3	577	broad.mit.edu	37	chr6	69653751	69653751	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgggaggaatggtcaccaTggagtttatgttcatttaca	11	14	11	5	0	2	0	2	0	0	0	2	3	2	3	1	4	1	2	1	4	4	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:69653751T>C	uc003pev.3	+	6	1508	c.1060T>C	c.(1060-1062)TGG>CGG	p.W354R	BAI3_uc010kak.2_Missense_Mutation_p.W354R	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	354	Extracellular (Potential).|TSP type-1 2.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ATGGTCACCATGGAGTTTATG	0.413													51	148					0	0	0	0	C	69653751	C	C	69653751	3	2	58	1	0	0	0	0	1	0	0	0	1302	1464	51	5	1074	5	BAI3	6	69653751	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	12640950	69653751	101461316	222	11607											
BAI3	577	broad.mit.edu	37	chr6	69703837	69703837	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaagggcaagttacatccctGcatctgatggtgtccaggta	11	10	11	9	0	1	1	0	1	1	0	3	1	3	1	2	3	2	4	2	3	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:69703837G>T	uc003pev.3	+	11	2360	c.1912G>T	c.(1912-1914)GCA>TCA	p.A638S	BAI3_uc010kak.2_Missense_Mutation_p.A638S	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	638	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TTACATCCCTGCATCTGATGG	0.453													24	68					4.4004e-07	4.98615e-07	1	0	T	69703837	T	T	69703837	3	4	58	1	0	0	0	0	1	0	0	0	1302	1319	46	4	1946	4	BAI3	6	69703837	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	50086	69703837	101411230	223	11608											
MYO6	4646	broad.mit.edu	37	chr6	76624544	76624544	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atacaggtaaggacgacatgGagatgtgtgagctgaatctt	13	10	13	5	1	1	3	0	2	1	1	1	6	1	4	0	3	2	2	0	3	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:76624544G>T	uc003pih.1	+	35	3952	c.3673G>T	c.(3673-3675)GAG>TAG	p.E1225*	MYO6_uc003pii.1_Nonsense_Mutation_p.E1202*|MYO6_uc003pij.1_Nonsense_Mutation_p.E173*	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	1234					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GGACGACATGGAGATGTGTGA	0.448													11	60					2.80697e-09	3.3773e-09	1	0	T	76624544	T	T	76624544	4	4	58	1	0	0	0	0	0	1	0	0	10134	1175	41	2	3807	2	MYO6	6	76624544	Nonsense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6920707	76624544	94490523	224	11609											
IMPG1	3617	broad.mit.edu	37	chr6	76715168	76715168	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caattttgttggaatcaaaaGacaggaggtcacttgcaggg	13	10	12	6	0	2	1	2	0	0	1	2	3	2	3	0	4	1	2	0	4	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:76715168G>T	uc003pik.1	-	10	1101	c.971C>A	c.(970-972)TCT>TAT	p.S324Y		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	324	SEA 1.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GGAATCAAAAGACAGGAGGTC	0.453													26	108					1.1804e-14	1.5855e-14	1	0	T	76715168	T	T	76715168	3	4	58	1	0	0	0	0	1	0	0	0	7767	942	33	2	1454	2	IMPG1	6	76715168	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	90624	76715168	94399899	225	11610											
HTR1E	3354	broad.mit.edu	37	chr6	87725859	87725859	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaggatcccccccttcgaCaatgatctagatcacccagg	11	8	7	15	1	3	2	2	1	1	1	5	4	4	3	4	2	0	0	4	2	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:87725859C>A	uc003pli.2	+	2	1510	c.807C>A	c.(805-807)GAC>GAA	p.D269E		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	269	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CCCCCTTCGACAATGATCTAG	0.502													67	218					4.67498e-28	7.33563e-28	1	0	A	87725859	A	A	87725859	3	1	58	1	0	0	0	0	1	0	0	0	7478	477	17	4	809	4	HTR1E	6	87725859	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	11010691	87725859	83389208	226	11611											
GABRR1	2569	broad.mit.edu	37	chr6	89888653	89888653	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctgaggccagggtcagctGcaccatcatcctgtcgggct	6	9	12	14	1	3	1	2	1	1	0	5	1	4	1	3	3	2	3	3	3	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:89888653G>T	uc003pna.2	-	10	1731	c.1276C>A	c.(1276-1278)CAG>AAG	p.Q426K	GABRR1_uc011dzv.1_Missense_Mutation_p.Q403K	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	426	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	AGGGTCAGCTGCACCATCATC	0.542													29	155					8.16721e-17	1.12817e-16	1	0	T	89888653	T	T	89888653	3	4	58	1	0	0	0	0	1	0	0	0	6210	1328	46	4	167	4	GABRR1	6	89888653	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2162794	89888653	81226414	227	11612											
MDN1	23195	broad.mit.edu	37	chr6	90383950	90383950	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaaaggtgatcctgtttccGcatccggcaaccagagggca	10	7	11	13	2	0	2	0	1	0	1	3	2	3	2	5	3	1	4	5	3	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:90383950G>A	uc003pnn.1	-	79	13236	c.13120C>T	c.(13120-13122)CGG>TGG	p.R4374W		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4374					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCCTGTTTCCGCATCCGGCAA	0.463													21	72					0	0	0	0	A	90383950	A	A	90383950	3	1	58	1	0	0	0	0	1	0	0	0	9468	1086	38	1	3766	1	MDN1	6	90383950	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	495297	90383950	80731117	228	11613											
MDN1	23195	broad.mit.edu	37	chr6	90402372	90402372	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcagacttcaccgagcaCaaagtgtctgcatgagcata	12	9	8	12	1	3	2	2	1	1	1	4	3	4	2	2	0	3	3	2	0	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:90402372C>A	uc003pnn.1	-	63	10493	c.10377G>T	c.(10375-10377)TTG>TTT	p.L3459F		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3459					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCACCGAGCACAAAGTGTCTG	0.587													39	156					1.04594e-18	1.48702e-18	1	0	A	90402372	A	A	90402372	3	1	58	1	0	0	0	0	1	0	0	0	9468	477	17	4	6573	4	MDN1	6	90402372	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	18422	90402372	80712695	229	11614											
MDN1	23195	broad.mit.edu	37	chr6	90402456	90402456	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctgtggccagggtccccagCctgtctgcaccaaccatact	7	8	10	16	0	1	0	0	0	1	0	2	0	2	0	6	2	4	2	6	2	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:90402456C>T	uc003pnn.1	-	63	10409	c.10293G>A	c.(10291-10293)AGG>AGA	p.R3431R		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3431					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGGTCCCCAGCCTGTCTGCAC	0.582													29	71					0	0	0	0	T	90402456	T	T	90402456	2	4	58	1	0	0	0	0	0	0	0	1	9468	738	26	4		4	MDN1	6	90402456	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	84	90402456	80712611	230	11615											
RFX6	222546	broad.mit.edu	37	chr6	117215197	117215197	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagagcagtgcatattaccActccgtttattctggaaagg	12	11	10	8	1	1	1	0	0	1	1	2	3	2	2	2	2	3	3	2	2	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:117215197A>T	uc003pxm.2	+	5	677	c.614A>T	c.(613-615)CAC>CTC	p.H205L		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	205					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GCATATTACCACTCCGTTTAT	0.393													38	140					0	0	0	0	T	117215197	T	T	117215197	3	4	58	1	0	0	0	0	1	0	0	0	13332	159	6	5	632	5	RFX6	6	117215197	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	26812741	117215197	53899870	231	11616											
RSPO3	84870	broad.mit.edu	37	chr6	127471641	127471641	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtaaaagtggattttacttAcaccttggaaagtgccttga	12	14	9	6	0	0	1	0	1	0	0	0	3	0	3	2	2	3	1	2	2	5	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:127471641A>G	uc003qar.2	+	3	650	c.360A>G	c.(358-360)TTA>TTG	p.L120L	RSPO3_uc003qas.1_Silent_p.L120L	NM_032784	NP_116173	Q9BXY4	RSPO3_HUMAN	R-spondin 3 precursor	120	FU 2.					extracellular region	heparin binding				0				GBM - Glioblastoma multiforme(226;0.0555)		GATTTTACTTACACCTTGGAA	0.368													17	112					0	0	0	0	G	127471641	G	G	127471641	2	3	58	1	0	0	0	0	0	0	0	1	13776	388	14	5		5	RSPO3	6	127471641	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	10256444	127471641	43643426	232	11617											
C6orf174	387104	broad.mit.edu	37	chr6	127796902	127796902	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgctctccttcttgcccgCgtcgctctcggcgtcgctgt	0	13	11	17	7	3	0	0	0	3	0	8	0	3	0	2	1	1	3	2	1	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:127796902C>T	uc003qbd.2	-	6	3134	c.2269G>A	c.(2269-2271)GCG>ACG	p.A757T	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	757						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TTCTTGCCCGCGTCGCTCTCG	0.697													28	90					0	0	0	0	T	127796902	T	T	127796902	3	4	58	1	0	0	0	0	1	0	0	0	2355	768	27	1	582	1	C6orf174	6	127796902	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	325261	127796902	43318165	233	11618											
THEMIS	387357	broad.mit.edu	37	chr6	128134032	128134032	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaaaccatagccttaccttgGgagacttgggcaggtctacc	11	9	10	11	0	1	1	0	0	1	1	1	2	1	1	4	3	4	1	4	3	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:128134032G>A	uc003qbi.2	-	5	2073	c.1754C>T	c.(1753-1755)CCC>CTC	p.P585L	THEMIS_uc010kfa.2_Missense_Mutation_p.P488L|THEMIS_uc011ebt.1_Missense_Mutation_p.P585L|THEMIS_uc010kfb.2_Missense_Mutation_p.P550L	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	585					negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						CCTTACCTTGGGAGACTTGGG	0.463													82	276					0	0	0	0	A	128134032	A	A	128134032	3	1	58	1	0	0	0	0	1	0	0	0	15926	1232	43	4	304	4	THEMIS	6	128134032	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	337130	128134032	42981035	234	11619											
LAMA2	3908	broad.mit.edu	37	chr6	129371138	129371138	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatgtggagaaaaaggacCtgaaatgtactgcaaattgg	17	8	11	5	0	0	2	0	1	0	1	0	4	0	3	1	3	3	2	1	3	6	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:129371138C>A	uc003qbn.2	+	2	293	c.188C>A	c.(187-189)CCT>CAT	p.P63H	LAMA2_uc003qbo.2_Missense_Mutation_p.P63H	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	63	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAAAAAGGACCTGAAATGTAC	0.448													28	82					1.12875e-08	1.33684e-08	1	0	A	129371138	A	A	129371138	3	1	58	1	0	0	0	0	1	0	0	0	8646	681	24	4	194	4	LAMA2	6	129371138	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1237106	129371138	41743929	235	11620											
L3MBTL3	84456	broad.mit.edu	37	chr6	130381238	130381238	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggcatgaaattagaaggcGtggatcctgagcatcagtct	11	11	12	7	1	2	3	1	2	1	1	3	4	3	4	1	3	1	2	1	3	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:130381238G>T	uc003qbt.2	+	10	987	c.817G>T	c.(817-819)GTG>TTG	p.V273L	L3MBTL3_uc003qbu.2_Missense_Mutation_p.V248L	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	273	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		ATTAGAAGGCGTGGATCCTGA	0.398													18	64					5.35356e-11	6.78915e-11	1	0	T	130381238	T	T	130381238	3	4	58	1	0	0	0	0	1	0	0	0	8633	1145	40	3	847	3	L3MBTL3	6	130381238	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1010100	130381238	40733829	236	11621											
L3MBTL3	84456	broad.mit.edu	37	chr6	130392248	130392248	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttcctggtacattttgacaActgggatgagagctatgact	10	14	10	7	0	0	3	0	3	0	1	1	5	1	4	1	2	3	2	1	2	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:130392248A>G	uc003qbt.2	+	13	1390	c.1220A>G	c.(1219-1221)AAC>AGC	p.N407S	L3MBTL3_uc003qbu.2_Missense_Mutation_p.N382S	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	407	MBT 2.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		CATTTTGACAACTGGGATGAG	0.313													64	223					0	0	0	0	G	130392248	G	G	130392248	3	3	58	1	0	0	0	0	1	0	0	0	8633	43	2	5	1262	5	L3MBTL3	6	130392248	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	11010	130392248	40722819	237	11622											
SAMD3	154075	broad.mit.edu	37	chr6	130535556	130535556	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttcagtccttgagtgttCtgcttgtattttttaattaa	8	20	7	6	0	2	1	1	1	1	0	3	2	3	1	1	0	1	3	1	0	3	9			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:130535556C>G	uc003qbv.2	-	5	521	c.195G>C	c.(193-195)CAG>CAC	p.Q65H	SAMD3_uc003qbx.2_Missense_Mutation_p.Q65H|SAMD3_uc003qbw.2_Missense_Mutation_p.Q65H|SAMD3_uc010kfg.1_Missense_Mutation_p.Q65H|SAMD3_uc003qby.2_Missense_Mutation_p.Q65H|SAMD3_uc003qbz.1_Missense_Mutation_p.Q24H	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	65	SAM.									ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CTTGAGTGTTCTGCTTGTATT	0.448													65	202					0	0	0	0	G	130535556	G	G	130535556	3	3	58	1	0	0	0	0	1	0	0	0	13885	912	32	2	1419	2	SAMD3	6	130535556	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	143308	130535556	40579511	238	11623											
CTGF	1490	broad.mit.edu	37	chr6	132271472	132271472	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggtttggtccttgggctcGtcacacacccactcctcgca	6	10	9	16	3	1	0	1	0	0	0	5	0	3	0	3	3	0	3	3	3	0	2	rs139453995		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:132271472G>A	uc003qcz.2	-	3	707	c.501C>T	c.(499-501)GAC>GAT	p.D167D		NM_001901	NP_001892	P29279	CTGF_HUMAN	connective tissue growth factor precursor	167	VWFC.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding				0	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		CCTTGGGCTCGTCACACACCC	0.632											OREG0017666	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	160					0	0	0	0	A	132271472	A	A	132271472	2	1	58	1	0	0	0	0	0	0	0	1	4025	1136	40	1		1	CTGF	6	132271472	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1735916	132271472	38843595	239	11624											
TAAR1	134864	broad.mit.edu	37	chr6	132966320	132966320	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aataatgtagtgaagaaaagGgtccatgactgtacagataa	18	9	10	4	0	0	4	0	2	0	2	1	4	1	4	1	1	1	2	1	1	8	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:132966320G>T	uc003qdm.1	-	1	823	c.823C>A	c.(823-825)CCT>ACT	p.P275T		NM_138327	NP_612200	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	275	Extracellular (Potential).					plasma membrane					0	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	TGAAGAAAAGGGTCCATGACT	0.368													21	95					1.50039e-11	1.92786e-11	1	0	T	132966320	T	T	132966320	3	4	58	1	0	0	0	0	1	0	0	0	15555	1232	43	4	200	4	TAAR1	6	132966320	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	694848	132966320	38148747	240	11625											
STXBP5	134957	broad.mit.edu	37	chr6	147655334	147655334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagggactgttgttccagagGatcgctgcaaatctccaacc	11	9	10	11	1	1	1	0	0	1	1	4	3	2	3	3	2	2	4	3	2	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:147655334G>A	uc003qlz.2	+	19	2283	c.2122G>A	c.(2122-2124)GAT>AAT	p.D708N	STXBP5_uc010khz.1_Missense_Mutation_p.D708N|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.D379N|STXBP5_uc003qma.2_Missense_Mutation_p.D55N	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	708					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TGTTCCAGAGGATCGCTGCAA	0.328													26	76					0	0	0	0	A	147655334	A	A	147655334	3	1	58	1	0	0	0	0	1	0	0	0	15422	1174	41	2	2196	2	STXBP5	6	147655334	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	14689014	147655334	23459733	241	11626											
RAET1G	353091	broad.mit.edu	37	chr6	150240901	150240901	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaaccgcacaccaccgtggtCcaggtctgaacttagggatg	10	7	12	12	2	1	1	0	1	1	0	2	3	2	2	4	3	2	1	4	3	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:150240901C>T	uc010kii.1	-	2	205	c.137G>A	c.(136-138)GGA>GAA	p.G46E	RAET1G_uc003qnm.2_RNA	NM_001001788	NP_001001788	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G precursor	46	MHC class I alpha-1 like.|Extracellular (Potential).				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		CCACCGTGGTCCAGGTCTGAA	0.552													7	202					0	0	0	0	T	150240901	T	T	150240901	3	4	58	1	0	0	0	0	1	0	0	0	13065	855	30	2	883	2	RAET1G	6	150240901	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2585567	150240901	20874166	242	11627											
SYNE1	23345	broad.mit.edu	37	chr6	152708424	152708424	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtggttgtaagggatgtTctattttttgatccactgat	7	18	11	5	0	1	2	0	2	1	0	2	3	2	3	1	2	0	4	1	2	2	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:152708424T>A	uc010kiw.2	-	54	8872	c.8270A>T	c.(8269-8271)GAA>GTA	p.E2757V	SYNE1_uc003qot.3_Missense_Mutation_p.E2764V|SYNE1_uc003qou.3_Missense_Mutation_p.E2757V|SYNE1_uc010kjb.1_Missense_Mutation_p.E2740V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2757	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TAAGGGATGTTCTATTTTTTG	0.458										HNSCC(10;0.0054)			41	145					0	0	0	0	A	152708424	A	A	152708424	3	1	58	1	0	0	0	0	1	0	0	0	15511	1783	62	5	18568	5	SYNE1	6	152708424	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	2467523	152708424	18406643	243	11628											
TIAM2	26230	broad.mit.edu	37	chr6	155450864	155450864	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaaaacgctggggaagctGgatgggtgtttaagggtcga	11	9	16	5	2	1	0	1	0	0	0	2	3	1	2	0	5	2	3	0	5	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:155450864G>T	uc003qqb.2	+	6	1780	c.507G>T	c.(505-507)CTG>CTT	p.L169L	TIAM2_uc003qqe.2_Silent_p.L169L	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	169					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGGGGAAGCTGGATGGGTGTT	0.587													17	68					2.39187e-15	3.23188e-15	1	0	T	155450864	T	T	155450864	2	4	58	1	0	0	0	0	0	0	0	1	15957	1335	47	4		4	TIAM2	6	155450864	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2742440	155450864	15664203	244	11629											
TULP4	56995	broad.mit.edu	37	chr6	158914657	158914658	+	Frame_Shift_Del	DEL	CT	-	-																															tgccccgggctgctcaggagCtctcccggtccccacggttg																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:158914657_158914658delCT	uc003qrf.2	+	10	3041_3042	c.1684_1685delCT	c.(1684-1686)CTCfs	p.L562fs	TULP4_uc003qrg.2_Frame_Shift_Del_p.L562fs	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	562					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		TGCTCAGGAGCTCTCCCGGTCC	0.649													---	---	---								-	158914658	-	-	158914657	7	5	58	1	0	1	0	1	0	0	0	0	16844	797	28	0	1722	0	TULP4	6	158914657	Frame_Shift_Del	DEL	CT	TCGA-CN-5360-01A-01D-1434-08	3463793	158914657	12200410	245	11630											
FNDC1	84624	broad.mit.edu	37	chr6	159660563	159660563	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttcagatctggaagggaccCccgtggtgagtcctgacggc	7	9	14	11	2	2	3	1	2	1	1	3	5	3	5	3	4	0	0	3	4	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:159660563C>A	uc010kjv.2	+	14	4395	c.4195C>A	c.(4195-4197)CCC>ACC	p.P1399T	FNDC1_uc010kjw.1_Missense_Mutation_p.P1284T	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1399						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GGAAGGGACCCCCGTGGTGAG	0.483													3	11					0.004672	0.00482065	1	0	A	159660563	A	A	159660563	3	1	58	1	0	0	0	0	1	0	0	0	6000	623	22	4	4249	4	FNDC1	6	159660563	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	745906	159660563	11454504	246	11631											
SMOC2	64094	broad.mit.edu	37	chr6	169064781	169064781	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtcatgctgaaagtacgtCtaatagacaggtaagtatgt	14	11	11	5	1	2	2	1	1	1	1	2	2	2	2	0	2	2	4	0	2	6	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:169064781C>T	uc003qws.1	+	12	1333	c.1313C>T	c.(1312-1314)TCT>TTT	p.S438F	SMOC2_uc003qwr.1_Missense_Mutation_p.S449F|SMOC2_uc011egu.1_Missense_Mutation_p.S115F	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	438					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		GAAAGTACGTCTAATAGACAG	0.294													18	55					0	0	0	0	T	169064781	T	T	169064781	3	4	58	1	0	0	0	0	1	0	0	0	14866	913	32	2	1392	2	SMOC2	6	169064781	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	9404218	169064781	2050286	247	11632											
RSPH10B2	728194	broad.mit.edu	37	chr7	6838029	6838029	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttgagagaggaagaggccaAgagacatgactatgaggtgg	14	6	16	5	0	0	6	0	3	0	3	0	9	0	7	1	4	0	0	1	4	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:6838029A>G	uc003sqw.1	+	21	2739	c.2468A>G	c.(2467-2469)AAG>AGG	p.K823R	RSPH10B2_uc010ktk.1_Missense_Mutation_p.K823R|RSPH10B2_uc010ktl.1_RNA	NM_173565	NP_775836	B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B	823										ovary(1)|pancreas(1)|skin(1)	3						GAAGAGGCCAAGAGACATGAC	0.483													18	125					0	0	0	0	G	6838029	G	G	6838029	3	3	58	1	0	0	0	0	1	0	0	0	13769	72	3	5	5231	5	RSPH10B2	7	6838029	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08		6838029	152300634	248	11633											
THSD7A	221981	broad.mit.edu	37	chr7	11416278	11416278	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtaaacccaggtctttagtCtcccatctaagaagaatgga	13	10	8	10	1	3	2	0	0	3	2	4	3	3	3	2	2	1	1	2	2	6	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:11416278C>G	uc003ssf.3	-	26	5060	c.4808G>C	c.(4807-4809)AGA>ACA	p.R1603T	uc003ssb.2_Intron|THSD7A_uc003ssd.3_Missense_Mutation_p.R107T	NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1603	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GGTCTTTAGTCTCCCATCTAA	0.353										HNSCC(18;0.044)			4	8					0	0	0	0	G	11416278	G	G	11416278	3	3	58	1	0	0	0	0	1	0	0	0	15945	913	32	2	173	2	THSD7A	7	11416278	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	4578249	11416278	147722385	249	11634											
TMEM195	392636	broad.mit.edu	37	chr7	15430298	15430298	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaaaacaagtatgttacctGcactttgattggttcaaatg	15	13	7	6	0	1	1	1	1	0	0	1	1	1	1	1	1	3	4	1	1	7	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:15430298G>C	uc003stb.1	-	8	990	c.820C>G	c.(820-822)CAG>GAG	p.Q274E		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	274					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TATGTTACCTGCACTTTGATT	0.269													30	136					0	0	0	0	C	15430298	C	C	15430298	3	2	58	1	0	0	0	0	1	0	0	0	16183	1328	46	4	541	4	TMEM195	7	15430298	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	4014020	15430298	143708365	250	11635											
TMEM195	392636	broad.mit.edu	37	chr7	15430330	15430330	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcaaatgtattaatgggaTgtgttaagccatatacaact	14	14	8	5	0	1	0	1	0	0	0	1	1	1	1	1	1	3	3	1	1	7	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:15430330T>C	uc003stb.1	-	8	958	c.788A>G	c.(787-789)CAT>CGT	p.H263R		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	263					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						ATTAATGGGATGTGTTAAGCC	0.294													35	153					0	0	0	0	C	15430330	C	C	15430330	3	2	58	1	0	0	0	0	1	0	0	0	16183	1464	51	5	573	5	TMEM195	7	15430330	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	32	15430330	143708333	251	11636											
ABCB5	340273	broad.mit.edu	37	chr7	20762764	20762764	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtattgctccagtacttgcCgtgacaggaatgattgaaac	12	11	10	8	1	0	3	0	3	0	0	1	4	1	4	2	1	4	3	2	1	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:20762764C>T	uc003suw.3	+	12	1758	c.1212C>T	c.(1210-1212)GCC>GCT	p.A404A	ABCB5_uc010kuh.2_Silent_p.A849A|ABCB5_uc003sux.1_Silent_p.A27A	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	404	Cytoplasmic (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CAGTACTTGCCGTGACAGGAA	0.388													33	94					0	0	0	0	T	20762764	T	T	20762764	2	4	58	1	0	0	0	0	0	0	0	1	44	639	23	1		1	ABCB5	7	20762764	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5332434	20762764	138375899	252	11637											
CHN2	1124	broad.mit.edu	37	chr7	29539573	29539573	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcaagaaagtgtactgttGtgacctcacaacacttgtga	13	11	9	8	0	2	3	2	2	0	1	2	4	2	3	1	0	2	2	1	0	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:29539573G>T	uc003szz.2	+	9	1267	c.830G>T	c.(829-831)TGT>TTT	p.C277F	CHN2_uc011jzs.1_Missense_Mutation_p.C352F|CHN2_uc010kva.2_Missense_Mutation_p.C47F|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Missense_Mutation_p.C242F|CHN2_uc011jzt.1_Missense_Mutation_p.C290F|CHN2_uc010kvd.2_Missense_Mutation_p.C133F|CHN2_uc011jzu.1_Missense_Mutation_p.C262F|CHN2_uc010kvg.2_Missense_Mutation_p.C141F|CHN2_uc010kvh.2_Intron|CHN2_uc010kvi.2_Missense_Mutation_p.C141F|CHN2_uc010kve.2_Missense_Mutation_p.C141F|CHN2_uc003taa.2_Missense_Mutation_p.C141F|CHN2_uc010kvf.2_Intron|CHN2_uc010kvj.2_Missense_Mutation_p.C96F|CHN2_uc010kvk.2_Intron|CHN2_uc010kvl.2_RNA|CHN2_uc010kvm.2_Missense_Mutation_p.C96F|CHN2_uc011jzv.1_Missense_Mutation_p.C70F	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	277	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						GTGTACTGTTGTGACCTCACA	0.443													13	46					2.27111e-07	2.58201e-07	1	0	T	29539573	T	T	29539573	3	4	58	1	0	0	0	0	1	0	0	0	3378	1377	48	4	1032	4	CHN2	7	29539573	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	8776809	29539573	129599090	253	11638											
NEUROD6	63974	broad.mit.edu	37	chr7	31378419	31378419	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgaatgtgagcagatctggtCtcttgccgattctcagaatt	9	13	10	9	2	3	3	1	1	3	2	5	5	3	3	1	1	2	1	1	1	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:31378419C>T	uc003tch.2	-	2	817	c.464G>A	c.(463-465)AGA>AAA	p.R155K		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	155					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						CAGATCTGGTCTCTTGCCGAT	0.458													19	88					0	0	0	0	T	31378419	T	T	31378419	3	4	58	1	0	0	0	0	1	0	0	0	10405	913	32	2	553	2	NEUROD6	7	31378419	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1838846	31378419	127760244	254	11639											
PSMA2	5683	broad.mit.edu	37	chr7	42966149	42966149	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtacctgtaatcggggccCatgccactgtacaccaaacc	12	7	8	14	1	0	0	0	0	0	0	1	0	0	0	5	2	4	3	5	2	5	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:42966149C>A	uc003thy.2	-	3	285	c.237G>T	c.(235-237)ATG>ATT	p.M79I	C7orf25_uc010kxr.2_Intron|PSMA2_uc010kxt.2_Missense_Mutation_p.M1I|PSMA2_uc003thz.1_Missense_Mutation_p.M1I	NM_002787	NP_002778	P25787	PSA2_HUMAN	proteasome subunit alpha type 2	79					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|response to virus|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity			large_intestine(2)|ovary(1)	3						AATCGGGGCCCATGCCACTGT	0.368													26	71					2.48779e-11	3.19056e-11	1	0	A	42966149	A	A	42966149	3	1	58	1	0	0	0	0	1	0	0	0	12729	594	21	4	491	4	PSMA2	7	42966149	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	11587730	42966149	116172514	255	11640											
OGDH	4967	broad.mit.edu	37	chr7	44736099	44736100	+	Frame_Shift_Del	DEL	AC	-	-																															gtctgacggaggatattctgAcacacatcgggaatgtggct																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:44736099_44736100delAC	uc003tln.2	+	14	1952_1953	c.1843_1844delAC	c.(1843-1845)ACAfs	p.T615fs	OGDH_uc011kbx.1_Frame_Shift_Del_p.T611fs|OGDH_uc011kby.1_Frame_Shift_Del_p.T465fs|OGDH_uc003tlp.2_Frame_Shift_Del_p.T626fs|OGDH_uc011kbz.1_Frame_Shift_Del_p.T410fs|OGDH_uc003tlo.1_Frame_Shift_Del_p.T448fs	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	615					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GGATATTCTGACACACATCGGG	0.545													---	---	---								-	44736100	-	-	44736099	7	5	58	1	0	1	0	1	0	0	0	0	10893	275	10	0	2066	0	OGDH	7	44736099	Frame_Shift_Del	DEL	AC	TCGA-CN-5360-01A-01D-1434-08	1769950	44736099	114402564	256	11641											
MYO1G	64005	broad.mit.edu	37	chr7	45004594	45004594	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcggcagccccagtcctgacGaagcccttgcagggccccca	7	5	11	18	2	0	1	0	1	0	0	2	2	1	1	6	2	3	2	6	2	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:45004594G>A	uc003tmh.2	-	18	2620	c.2476C>T	c.(2476-2478)CGT>TGT	p.R826C	MYO1G_uc003tmf.2_Missense_Mutation_p.R269C|MYO1G_uc003tmg.2_Missense_Mutation_p.R588C|MYO1G_uc010kym.2_Missense_Mutation_p.R711C	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	826				R->A: Reduced membrane association.		myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						CAGTCCTGACGAAGCCCTTGC	0.677													31	98					0	0	0	0	A	45004594	A	A	45004594	3	1	58	1	0	0	0	0	1	0	0	0	10127	1058	37	1	600	1	MYO1G	7	45004594	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	268495	45004594	114134069	257	11642											
UPP1	7378	broad.mit.edu	37	chr7	48141563	48141563	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccatgtataaagtaggacCggtgctgtctgtcagtgtga	9	12	13	7	1	2	1	1	1	1	0	2	2	2	2	2	2	2	3	2	2	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:48141563C>T	uc003toj.2	+	6	834	c.305C>T	c.(304-306)CCG>CTG	p.P102L	UPP1_uc003tok.2_Missense_Mutation_p.P102L|UPP1_uc003tol.2_Missense_Mutation_p.P102L|UPP1_uc011kcg.1_Missense_Mutation_p.P102L|UPP1_uc011kch.1_Intron|UPP1_uc003ton.2_Intron|UPP1_uc003too.2_Intron	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	102					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						AAAGTAGGACCGGTGCTGTCT	0.572													28	64					0	0	0	0	T	48141563	T	T	48141563	3	4	58	1	0	0	0	0	1	0	0	0	17080	652	23	1	315	1	UPP1	7	48141563	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3136969	48141563	110997100	258	11643											
WBSCR17	64409	broad.mit.edu	37	chr7	70881051	70881051	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggaattcaccgctggctggTaggtcatgagctgaaactca	10	10	12	9	1	3	2	3	2	0	0	3	3	3	3	1	4	2	4	1	4	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:70881051T>C	uc003tvy.2	+	4	764	c.764_splice	c.e4+2	p.W255_splice	WBSCR17_uc003tvz.2_Splice_Site	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide							Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CGCTGGCTGGTAGGTCATGAG	0.582													8	78					0	0	0	0	C	70881051	C	C	70881051	5	2	58	1	0	0	0	0	0	0	1	0	17332	1652	57	5	780	5	WBSCR17	7	70881051	Splice_Site	SNP	T	TCGA-CN-5360-01A-01D-1434-08	22739488	70881051	88257612	259	11644											
PCLO	27445	broad.mit.edu	37	chr7	82579581	82579581	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgtttgtacaccactgtcCactatctttttaaaacttcg	9	16	4	12	2	1	0	0	0	1	0	4	0	3	0	3	0	2	2	3	0	4	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:82579581C>A	uc003uhx.2	-	6	10612	c.10323G>T	c.(10321-10323)GTG>GTT	p.V3441V	PCLO_uc003uhv.2_Silent_p.V3441V|PCLO_uc010lec.2_Silent_p.V406V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3372					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CACCACTGTCCACTATCTTTT	0.433													65	81					9.40535e-28	1.47242e-27	1	0	A	82579581	A	A	82579581	2	1	58	1	0	0	0	0	0	0	0	1	11637	581	21	4		4	PCLO	7	82579581	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	11698530	82579581	76559082	260	11645											
ZNF804B	219578	broad.mit.edu	37	chr7	88963725	88963725	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtatctcttatggctgcaacCcactgtattttgattttaag	9	17	7	8	0	1	1	0	1	1	0	2	1	1	1	1	1	2	4	1	1	5	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:88963725C>A	uc011khi.1	+	4	1967	c.1429C>A	c.(1429-1431)CCA>ACA	p.P477T		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	477						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TGGCTGCAACCCACTGTATTT	0.428										HNSCC(36;0.09)			56	43					4.33383e-22	6.45807e-22	1	0	A	88963725	A	A	88963725	3	1	58	1	0	0	0	0	1	0	0	0	18238	623	22	4	1443	4	ZNF804B	7	88963725	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	6384144	88963725	70174938	261	11646											
AKAP9	10142	broad.mit.edu	37	chr7	91730192	91730192	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttccaggttttcattgaatgGtggtgccaacattgaagcca	10	13	10	8	0	1	2	1	2	0	0	2	2	2	2	3	3	3	1	3	3	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:91730192G>C	uc003ulg.2	+	45	11144	c.10919G>C	c.(10918-10920)GGT>GCT	p.G3640A	AKAP9_uc003ulf.2_Missense_Mutation_p.G3632A|AKAP9_uc003uli.2_Missense_Mutation_p.G3263A|AKAP9_uc003ulj.2_Missense_Mutation_p.G1410A|AKAP9_uc003ull.2_Missense_Mutation_p.G536A	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3644	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCATTGAATGGTGGTGCCAAC	0.393			T	BRAF	papillary thyroid								109	128					0	0	0	0	C	91730192	C	C	91730192	3	2	58	1	0	0	0	0	1	0	0	0	459	1261	44	4	11097	4	AKAP9	7	91730192	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2766467	91730192	67408471	262	11647											
COL1A2	1278	broad.mit.edu	37	chr7	94049949	94049949	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccacaggccccgttggagctGctggcccagctgtaagttga	7	8	13	13	1	0	1	0	1	0	0	0	2	0	2	4	3	3	6	4	3	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:94049949G>T	uc003ung.1	+	37	2755	c.2284G>T	c.(2284-2286)GCT>TCT	p.A762S	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	762			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CGTTGGAGCTGCTGGCCCAGC	0.512										HNSCC(75;0.22)			4	8					0.00909568	0.00927269	1	0	T	94049949	T	T	94049949	3	4	58	1	0	0	0	0	1	0	0	0	3693	1319	46	4	2430	4	COL1A2	7	94049949	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2319757	94049949	65088714	263	11648											
PON1	5444	broad.mit.edu	37	chr7	94931576	94931576	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcatgccattgggatggcAtccaacccaaaggtctcctg	9	11	9	12	0	2	0	1	0	1	0	4	1	3	1	4	3	2	1	4	3	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:94931576A>T	uc003uns.2	-	8	947	c.850T>A	c.(850-852)TGC>AGC	p.C284S	PON1_uc011kih.1_Missense_Mutation_p.C284S	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	284				C->A,S: No loss of activity.	aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TTGGGATGGCATCCAACCCAA	0.388													58	59					0	0	0	0	T	94931576	T	T	94931576	3	4	58	1	0	0	0	0	1	0	0	0	12303	217	8	5	225	5	PON1	7	94931576	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	881627	94931576	64207087	264	11649											
DLX5	1749	broad.mit.edu	37	chr7	96650323	96650324	+	Missense_Mutation	DNP	CG	AA	AA																															gtgctccgggggcatctcccCgtttttcatgatcttcttga																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:96650323_96650324CG>AA	uc003uon.2	-	3	802_803	c.594_595CG>TT	c.(592-597)AACGGG>AATTGG	p.G199W		NM_005221	NP_005212	P56178	DLX5_HUMAN	distal-less homeobox 5	199					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GGCATCTCCCCGTTTTTCATGA	0.574													16	96					0	0	0	0	AA	96650324	AA	AA	96650323	3	1	58	1	0	0	0	0	1	0	0	0	4596	652	23	3	278	3	DLX5	7	96650323	Missense_Mutation	DNP	CG	TCGA-CN-5360-01A-01D-1434-08	1718747	96650323	62488340	265	11650											
LMTK2	22853	broad.mit.edu	37	chr7	97822447	97822447	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggactctcctggcgagagTgaggagaccctgcgactcac	9	6	13	13	2	2	3	1	1	1	2	3	7	2	4	2	3	1	0	2	3	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:97822447T>C	uc003upd.1	+	11	2963	c.2670T>C	c.(2668-2670)AGT>AGC	p.S890S		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	890					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CTGGCGAGAGTGAGGAGACCC	0.557													51	50					0	0	0	0	C	97822447	C	C	97822447	2	2	58	1	0	0	0	0	0	0	0	1	8901	1693	59	5		5	LMTK2	7	97822447	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1172124	97822447	61316216	266	11651											
CUX1	1523	broad.mit.edu	37	chr7	101892287	101892287	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaccgcctggagaaggccGccagccgggaggaacctatc	9	4	13	15	3	0	1	0	0	0	1	2	4	1	3	7	4	2	0	7	4	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:101892287G>A	uc003uyx.3	+	24	4521	c.4483G>A	c.(4483-4485)GCC>ACC	p.A1495T	CUX1_uc003uys.3_Missense_Mutation_p.A1506T|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	1495					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GGAGAAGGCCGCCAGCCGGGA	0.726													6	9					0	0	0	0	A	101892287	A	A	101892287	3	1	58	1	0	0	0	0	1	0	0	0	4081	1087	38	1	4644	1	CUX1	7	101892287	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	4069840	101892287	57246376	267	11652											
RINT1	60561	broad.mit.edu	37	chr7	105190713	105190713	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtgtatttttttagcttgaAttttctcggggccttatgat	6	21	9	5	1	1	2	0	2	1	0	2	2	1	2	1	2	1	2	1	2	4	9			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:105190713A>G	uc003vda.1	+	9	1344	c.1113A>G	c.(1111-1113)GAA>GAG	p.E371E	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	371	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						TTTAGCTTGAATTTTCTCGGG	0.363													166	188					0	0	0	0	G	105190713	G	G	105190713	2	3	58	1	0	0	0	0	0	0	0	1	13441	98	4	5		5	RINT1	7	105190713	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	3298426	105190713	53947950	268	11653											
NAMPT	10135	broad.mit.edu	37	chr7	105909600	105909600	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttggtttcagttacttacCtcttgggaagagactcctct	7	15	10	9	0	3	1	1	0	2	1	4	3	4	2	2	3	2	3	2	3	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:105909600C>A	uc003vdq.2	-	5	914	c.606G>T	c.(604-606)GAG>GAT	p.E202D	NAMPT_uc003vdr.1_Missense_Mutation_p.E202D|NAMPT_uc011klu.1_Missense_Mutation_p.E115D	NM_005746	NP_005737	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	202					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			large_intestine(1)	1						AGTTACTTACCTCTTGGGAAG	0.358													55	67					3.93605e-18	5.54959e-18	1	0	A	105909600	A	A	105909600	3	1	58	1	0	0	0	0	1	0	0	0	10202	695	24	4	897	4	NAMPT	7	105909600	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	718887	105909600	53229063	269	11654											
HBP1	26959	broad.mit.edu	37	chr7	106822945	106822945	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaatacctcagacataccAgaaactacttaccgtgaaaa	19	7	4	11	1	1	3	1	1	0	2	1	3	1	3	3	0	5	0	3	0	9	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:106822945A>G	uc003vdy.2	+	3	483	c.297A>G	c.(295-297)CCA>CCG	p.P99P	HBP1_uc011klv.1_Silent_p.P109P|HBP1_uc003vdz.2_Silent_p.P99P|HBP1_uc003vea.2_Silent_p.P99P|HBP1_uc003veb.1_Silent_p.P99P	NM_012257	NP_036389	O60381	HBP1_HUMAN	HMG-box transcription factor 1	99					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			skin(1)	1						CAGACATACCAGAAACTACTT	0.423													49	71					0	0	0	0	G	106822945	G	G	106822945	2	3	58	1	0	0	0	0	0	0	0	1	7024	175	7	5		5	HBP1	7	106822945	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	913345	106822945	52315718	270	11655											
WNT2	7472	broad.mit.edu	37	chr7	116955239	116955239	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccatagtcaatgttatcActgcagccaccccaatcaaa	14	9	4	14	0	3	0	3	0	0	0	4	0	4	0	4	0	2	2	4	0	5	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:116955239A>T	uc003viz.2	-	3	774	c.474T>A	c.(472-474)AGT>AGA	p.S158R	WNT2_uc003vja.2_Missense_Mutation_p.S62R	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	158					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CAATGTTATCACTGCAGCCAC	0.433													80	109					0	0	0	0	T	116955239	T	T	116955239	3	4	58	1	0	0	0	0	1	0	0	0	17454	156	6	5	620	5	WNT2	7	116955239	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	10132294	116955239	42183424	271	11656											
IQUB	154865	broad.mit.edu	37	chr7	123104887	123104887	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagagaaaaatgtagaatacCttaaggtattttgcaacttc	16	13	7	5	0	0	2	0	0	0	2	1	3	0	2	1	1	3	3	1	1	9	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:123104887C>A	uc003vkn.2	-	10	2335	c.1758G>T	c.(1756-1758)AAG>AAT	p.K586N	IQUB_uc003vko.2_Missense_Mutation_p.K586N|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Missense_Mutation_p.K586N	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	586										ovary(3)|large_intestine(1)	4						TGTAGAATACCTTAAGGTATT	0.303													29	140					2.12542e-12	2.76223e-12	1	0	A	123104887	A	A	123104887	3	1	58	1	0	0	0	0	1	0	0	0	7859	695	24	4	633	4	IQUB	7	123104887	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	6149648	123104887	36033776	272	11657											
IQUB	154865	broad.mit.edu	37	chr7	123152340	123152340	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaaaagcatcatcactctCttctgttgaattgactatat	13	15	4	9	0	5	2	3	2	2	0	6	2	5	2	0	0	1	2	0	0	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:123152340C>A	uc003vkn.2	-	2	632	c.55G>T	c.(55-57)GAG>TAG	p.E19*	IQUB_uc003vko.2_Nonsense_Mutation_p.E19*|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Nonsense_Mutation_p.E19*|IQUB_uc003vkq.2_Nonsense_Mutation_p.E19*	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	19										ovary(3)|large_intestine(1)	4						TCATCACTCTCTTCTGTTGAA	0.348													25	147					1.96895e-08	2.31581e-08	1	0	A	123152340	A	A	123152340	4	1	58	1	0	0	0	0	0	1	0	0	7859	922	32	2	2368	2	IQUB	7	123152340	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	47453	123152340	35986323	273	11658											
POT1	25913	broad.mit.edu	37	chr7	124499083	124499083	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtcagattttgtagccgatgGatgtgacttaaatcaccttc	10	14	9	8	1	2	2	2	1	0	1	3	4	2	3	2	1	1	1	2	1	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:124499083G>A	uc003vlm.2	-	9	1231	c.630C>T	c.(628-630)ATC>ATT	p.I210I	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Silent_p.I79I|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	210					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						GTAGCCGATGGATGTGACTTA	0.393													60	59					0	0	0	0	A	124499083	A	A	124499083	2	1	58	1	0	0	0	0	0	0	0	1	12315	1164	41	2		2	POT1	7	124499083	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1346743	124499083	34639580	274	11659											
KLF14	136259	broad.mit.edu	37	chr7	130418350	130418350	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggggcggggcctgcccctaGggcccctccagagaacccac	6	3	15	17	1	0	1	0	0	0	1	1	2	1	1	7	5	2	0	7	5	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:130418350G>C	uc003vqk.1	-	1	511	c.511C>G	c.(511-513)CTA>GTA	p.L171V		NM_138693	NP_619638	Q8TD94	KLF14_HUMAN	Kruppel-like factor 14	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(18;0.0435)					CCTGCCCCTAGGGCCCCTCCA	0.741													4	10					0	0	0	0	C	130418350	C	C	130418350	3	2	58	1	0	0	0	0	1	0	0	0	8381	991	35	4	464	4	KLF14	7	130418350	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5919267	130418350	28720313	275	11660											
PLXNA4	91584	broad.mit.edu	37	chr7	132193309	132193309	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accaggtgattgaaaccctcGgcgggctctcctcggaatgt	8	9	12	12	3	1	2	0	2	1	0	4	3	1	3	3	4	1	1	3	4	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:132193309G>T	uc003vra.3	-	2	373	c.144C>A	c.(142-144)GCC>GCA	p.A48A	PLXNA4_uc003vrc.2_Silent_p.A48A|PLXNA4_uc003vrb.2_Silent_p.A48A	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	48	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGAAACCCTCGGCGGGCTCTC	0.587													18	90					9.16793e-09	1.08769e-08	1	0	T	132193309	T	T	132193309	2	4	58	1	0	0	0	0	0	0	0	1	12177	1103	39	3		3	PLXNA4	7	132193309	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1774959	132193309	26945354	276	11661											
TRIM24	8805	broad.mit.edu	37	chr7	138261116	138261116	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtatggtttccccctcctcAggacctgttactatgactag	7	14	8	12	0	1	1	1	1	0	0	3	2	3	2	4	2	1	3	4	2	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:138261116A>T	uc003vuc.2	+	13	2230	c.2015_splice	c.e13-2	p.G672_splice	TRIM24_uc003vub.2_Splice_Site_p.G638_splice	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha						cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						CCCCCTCCTCAGGACCTGTTA	0.423													25	130					0	0	0	0	T	138261116	T	T	138261116	5	4	58	1	0	0	0	0	0	0	1	0	16565	202	7	5	2063	5	TRIM24	7	138261116	Splice_Site	SNP	A	TCGA-CN-5360-01A-01D-1434-08	6067807	138261116	20877547	277	11662											
KIAA1549	57670	broad.mit.edu	37	chr7	138603874	138603874	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaaaccatccgtggagtggtCcagtgagtatctggcagaaa	12	8	13	8	1	1	2	0	1	1	1	3	4	3	3	3	3	1	2	3	3	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:138603874C>A	uc011kql.1	-	2	547	c.498G>T	c.(496-498)TGG>TGT	p.W166C	KIAA1549_uc003vuk.3_Missense_Mutation_p.W116C|KIAA1549_uc011kqj.1_Missense_Mutation_p.W166C	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	166						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GTGGAGTGGTCCAGTGAGTAT	0.498			O	BRAF	pilocytic astrocytoma								156	175					7.08382e-60	1.16243e-59	1	0	A	138603874	A	A	138603874	3	1	58	1	0	0	0	0	1	0	0	0	8283	856	30	2	5430	2	KIAA1549	7	138603874	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	342758	138603874	20534789	278	11663											
MGAM	8972	broad.mit.edu	37	chr7	141754672	141754672	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cattaagaagaatccatttgGgattgaaattcgccggaaga	15	10	10	6	2	0	4	0	1	0	3	2	6	1	6	2	2	0	0	2	2	5	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:141754672G>T	uc003vwy.2	+	27	3332	c.3278G>T	c.(3277-3279)GGG>GTG	p.G1093V		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1093	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AATCCATTTGGGATTGAAATT	0.493													67	104					1.77791e-30	2.81572e-30	1	0	T	141754672	T	T	141754672	3	4	58	1	0	0	0	0	1	0	0	0	9594	1232	43	4	3380	4	MGAM	7	141754672	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3150798	141754672	17383991	279	11664											
MGAM	8972	broad.mit.edu	37	chr7	141796147	141796147	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaggtttgtgtcagaccagGtgacatgggacatagacagt	11	9	13	8	0	1	3	1	1	0	2	1	4	1	4	2	3	0	1	2	3	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:141796147G>A	uc003vwy.2	+	42	4990	c.4936G>A	c.(4936-4938)GTG>ATG	p.V1646M		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1646	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTCAGACCAGGTGACATGGGA	0.572													47	40					0	0	0	0	A	141796147	A	A	141796147	3	1	58	1	0	0	0	0	1	0	0	0	9594	1261	44	4	5098	4	MGAM	7	141796147	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	41475	141796147	17342516	280	11665											
C7orf34	135927	broad.mit.edu	37	chr7	142636723	142636723	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtgggcaggtccatgcCtcccctggccccccagctct	3	8	13	17	0	1	0	0	0	1	0	3	0	3	0	7	4	2	2	7	4	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:142636723C>T	uc003wca.2	+	1	121	c.80C>T	c.(79-81)CCT>CTT	p.P27L		NM_178829	NP_849151	Q96L11	CG034_HUMAN	hypothetical protein LOC135927	2						extracellular region					0	Melanoma(164;0.059)					AGGTCCATGCCTCCCCTGGCC	0.662													14	60					0	0	0	0	T	142636723	T	T	142636723	3	4	58	1	0	0	0	0	1	0	0	0	2400	681	24	4	82	4	C7orf34	7	142636723	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	840576	142636723	16501940	281	11666											
KRBA1	84626	broad.mit.edu	37	chr7	149420905	149420905	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctccccgaggcccaggacAggcatcccagtccctcagga	9	4	11	17	1	1	0	1	0	0	0	4	3	4	2	5	4	1	2	5	4	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:149420905A>T	uc003wfz.2	+	8	1252	c.853A>T	c.(853-855)AGG>TGG	p.R285W	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_5'UTR	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	285										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCCCAGGACAGGCATCCCAG	0.587													13	80					0	0	0	0	T	149420905	T	T	149420905	3	4	58	1	0	0	0	0	1	0	0	0	8478	179	7	5	879	5	KRBA1	7	149420905	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	6784182	149420905	9717758	282	11667											
ZNF467	168544	broad.mit.edu	37	chr7	149462101	149462101	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccaggtgcgacttgcggCtgaagcggcggccgcactga	6	5	17	13	5	0	2	0	2	0	0	0	3	0	2	2	5	3	2	2	5	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:149462101C>T	uc003wgd.2	-	5	1631	c.1490G>A	c.(1489-1491)AGC>AAC	p.S497N	ZNF467_uc003wgc.2_Intron	NM_207336	NP_997219	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	497	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGACTTGCGGCTGAAGCGGCG	0.716													8	19					0	0	0	0	T	149462101	T	T	149462101	3	4	58	1	0	0	0	0	1	0	0	0	17994	797	28	4	301	4	ZNF467	7	149462101	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	41196	149462101	9676562	283	11668											
NOS3	4846	broad.mit.edu	37	chr7	150696317	150696317	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgggcctgcgctggtacgcCctcccggcagtgtccaacat	5	8	12	16	3	0	0	0	0	0	0	2	0	2	0	4	3	3	3	4	3	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:150696317C>A	uc003wif.2	+	9	1292	c.996C>A	c.(994-996)GCC>GCA	p.A332A	NOS3_uc011kuy.1_Silent_p.A126A|NOS3_uc011kuz.1_Silent_p.A332A|NOS3_uc011kva.1_Silent_p.A332A|NOS3_uc011kvb.1_Silent_p.A332A	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	332	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GCTGGTACGCCCTCCCGGCAG	0.647													130	124					4.07488e-59	6.67065e-59	1	0	A	150696317	A	A	150696317	2	1	58	1	0	0	0	0	0	0	0	1	10598	610	22	4		4	NOS3	7	150696317	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1234216	150696317	8442346	284	11669											
AGAP3	116988	broad.mit.edu	37	chr7	150817174	150817174	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcgcatcgagaccatcgctgCctcctccacccccacaccca	8	5	6	22	3	0	1	0	0	0	1	4	2	2	1	7	0	1	2	7	0	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:150817174C>G	uc003wjg.1	+	8	1073	c.1070C>G	c.(1069-1071)GCC>GGC	p.A357G	AGAP3_uc003wje.1_Missense_Mutation_p.A129G|AGAP3_uc003wjf.1_Missense_Mutation_p.A357G|AGAP3_uc010lpy.1_Intron|AGAP3_uc003wjh.1_Missense_Mutation_p.A537G|AGAP3_uc003wji.1_5'Flank	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	321	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						ACCATCGCTGCCTCCTCCACC	0.667													3	64					0	0	0	0	G	150817174	G	G	150817174	3	3	58	1	0	0	0	0	1	0	0	0	369	739	26	4	1100	4	AGAP3	7	150817174	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	120857	150817174	8321489	285	11670											
MLL3	58508	broad.mit.edu	37	chr7	151879345	151879345	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtctgagcctgagaaagaCtatcctggatgggaatccgg	12	8	13	8	1	1	3	0	2	1	2	3	6	3	5	3	3	1	0	3	3	4	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:151879345C>G	uc003wla.2	-	36	5819	c.5600G>C	c.(5599-5601)AGT>ACT	p.S1867T	MLL3_uc003wkz.2_Missense_Mutation_p.S928T	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1867	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTGAGAAAGACTATCCTGGAT	0.522			N		medulloblastoma								27	193					0	0	0	0	G	151879345	G	G	151879345	3	3	58	1	0	0	0	0	1	0	0	0	9675	565	20	4	9231	4	MLL3	7	151879345	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1062171	151879345	7259318	286	11671											
DPP6	1804	broad.mit.edu	37	chr7	154681206	154681206	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagcagaactcattacacAactaattaggggaaaggcta	17	7	8	9	0	1	1	1	0	0	1	1	2	1	2	0	3	4	2	0	3	7	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:154681206A>G	uc003wlk.2	+	25	2546	c.2417A>G	c.(2416-2418)CAA>CGA	p.Q806R	DPP6_uc003wli.2_Missense_Mutation_p.Q742R|DPP6_uc003wlm.2_Missense_Mutation_p.Q744R|DPP6_uc011kvq.1_Missense_Mutation_p.Q699R	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	806	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CTCATTACACAACTAATTAGG	0.378													9	15					0	0	0	0	G	154681206	G	G	154681206	3	3	58	1	0	0	0	0	1	0	0	0	4752	130	5	5	2631	5	DPP6	7	154681206	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	2801861	154681206	4457457	287	11672											
DLGAP2	9228	broad.mit.edu	37	chr8	1513941	1513941	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgggagttacattaaagcCatgggggacgaggagagcgg	12	6	18	5	2	0	1	0	0	0	1	0	5	0	3	1	5	3	1	1	5	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:1513941C>T	uc003wpl.2	+	3	1180	c.1083C>T	c.(1081-1083)GCC>GCT	p.A361A	DLGAP2_uc003wpm.2_Silent_p.A361A	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	440					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACATTAAAGCCATGGGGGACG	0.572													4	19					0	0	0	0	T	1513941	T	T	1513941	2	4	58	1	0	0	0	0	0	0	0	1	4582	581	21	4		4	DLGAP2	8	1513941	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08		1513941	144850081	288	11673											
DEFB4A	1673	broad.mit.edu	37	chr8	7752250	7752250	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccatgagggtcttgtatCtcctcttctcgttcctcttc	4	16	7	14	1	5	1	0	1	5	0	9	1	6	1	3	1	1	2	3	1	1	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:7752250C>A	uc003wsd.2	+	1	52	c.16C>A	c.(16-18)CTC>ATC	p.L6I		NM_004942	NP_004933	O15263	DFB4A_HUMAN	defensin, beta 4 precursor	6					chemotaxis|defense response to bacterium|G-protein coupled receptor protein signaling pathway|immune response	extracellular region					0						GGTCTTGTATCTCCTCTTCTC	0.527													7	111					0.000673444	0.000708834	1	0	A	7752250	A	A	7752250	3	1	58	1	0	0	0	0	1	0	0	0	4443	913	32	2	18	2	DEFB4A	8	7752250	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	6238309	7752250	138611772	289	11674											
DLC1	10395	broad.mit.edu	37	chr8	13357323	13357323	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcatggctgtcattttcGtccacatcctttgaaagatg	8	15	7	11	1	2	2	2	1	0	1	5	2	4	2	3	1	0	1	3	1	1	4	rs146650078		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:13357323G>A	uc003wwm.2	-	2	702	c.258C>T	c.(256-258)GAC>GAT	p.D86D	DLC1_uc003wwn.2_Silent_p.D86D|DLC1_uc011kxy.1_Silent_p.D86D	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	86					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TGTCATTTTCGTCCACATCCT	0.443													9	362					0	0	0	0	A	13357323	A	A	13357323	2	1	58	1	0	0	0	0	0	0	0	1	4572	1136	40	1		1	DLC1	8	13357323	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5605073	13357323	133006699	290	11675											
KIF13B	23303	broad.mit.edu	37	chr8	29025078	29025078	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagtagccaccatggcggTcttgctgttacccccgaggc	7	8	11	15	2	1	0	0	0	1	0	1	1	1	0	4	3	3	3	4	3	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:29025078T>A	uc003xhh.3	-	11	1029	c.970A>T	c.(970-972)ACC>TCC	p.T324S	KIF13B_uc003xhj.2_Missense_Mutation_p.T221S|KIF13B_uc010lvf.1_Missense_Mutation_p.T260S	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	324					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		ACCATGGCGGTCTTGCTGTTA	0.428													50	66					0	0	0	0	A	29025078	A	A	29025078	3	1	58	1	0	0	0	0	1	0	0	0	8314	1667	58	5	4630	5	KIF13B	8	29025078	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	15667755	29025078	117338944	291	11676											
FAM150A	389658	broad.mit.edu	37	chr8	53451006	53451006	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcacagggtagttttgctaGgtctgggagcacagtggact	8	11	14	8	0	2	0	1	0	1	0	2	2	2	2	0	4	2	4	0	4	2	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:53451006G>C	uc003xrd.2	-	4	592	c.387C>G	c.(385-387)ACC>ACG	p.T129T	FAM150A_uc011ldt.1_Intron	NM_207413	NP_997296	Q6UXT8	F150A_HUMAN	hypothetical protein LOC389658 precursor	129						extracellular region					0		Lung NSC(129;0.0919)|all_epithelial(80;0.125)|all_lung(136;0.17)				AGTTTTGCTAGGTCTGGGAGC	0.264													15	25					0	0	0	0	C	53451006	C	C	53451006	2	2	58	1	0	0	0	0	0	0	0	1	5484	987	35	4		4	FAM150A	8	53451006	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	24425928	53451006	92913016	292	11677											
OPRK1	4986	broad.mit.edu	37	chr8	54142037	54142037	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgggattcaggctactgttGgtatagcctaaggcgatgca	10	11	13	7	1	1	0	1	0	0	0	1	2	1	1	1	4	3	4	1	4	4	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:54142037G>T	uc003xrh.1	-	3	1338	c.963C>A	c.(961-963)ACC>ACA	p.T321T	OPRK1_uc003xri.1_Silent_p.T321T|OPRK1_uc010lyc.1_Silent_p.T232T	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	321	Helical; Name=7; (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	GGCTACTGTTGGTATAGCCTA	0.517													14	15					7.93312e-07	8.90026e-07	1	0	T	54142037	T	T	54142037	2	4	58	1	0	0	0	0	0	0	0	1	10939	1335	47	4		4	OPRK1	8	54142037	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	691031	54142037	92221985	293	11678											
RP1	6101	broad.mit.edu	37	chr8	55542575	55542575	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acacatcattgttagttgtgGgtaatgtggattcaaataca	13	14	9	5	0	2	0	2	0	0	0	2	1	2	1	0	2	1	3	0	2	4	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:55542575G>T	uc003xsd.1	+	4	6281	c.6133G>T	c.(6133-6135)GGT>TGT	p.G2045C	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	2045					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GTTAGTTGTGGGTAATGTGGA	0.353													25	53					2.27525e-19	3.2967e-19	1	0	T	55542575	T	T	55542575	3	4	58	1	0	0	0	0	1	0	0	0	13597	1232	43	4	6143	4	RP1	8	55542575	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1400538	55542575	90821447	294	11679											
PLAG1	5324	broad.mit.edu	37	chr8	57079634	57079634	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtcgagtcaggtgatcctttCgcccaaatctctgtgcacaa	9	11	9	12	2	2	1	1	1	1	0	6	2	3	1	2	1	1	1	2	1	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:57079634C>G	uc003xsq.3	-	3	1122	c.671G>C	c.(670-672)CGA>CCA	p.R224P	PLAG1_uc003xsr.3_Missense_Mutation_p.R224P|PLAG1_uc010lyi.2_Missense_Mutation_p.R224P|PLAG1_uc010lyj.2_Missense_Mutation_p.R142P	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	224	Decreased nuclear import with localization in the nucleus but also in the cytoplasm.|C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GTGATCCTTTCGCCCAAATCT	0.478			T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								36	46					0	0	0	0	G	57079634	G	G	57079634	3	3	58	1	0	0	0	0	1	0	0	0	12073	884	31	3	835	3	PLAG1	8	57079634	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1537059	57079634	89284388	295	11680											
TRIM55	84675	broad.mit.edu	37	chr8	67039550	67039550	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttttccaaagagcagcagaCcatggataacttagagaagc	15	9	9	8	0	0	3	0	0	0	3	1	5	1	4	2	1	4	2	2	1	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:67039550C>G	uc003xvv.2	+	1	273	c.47C>G	c.(46-48)ACC>AGC	p.T16S	TRIM55_uc003xvu.2_Missense_Mutation_p.T16S|TRIM55_uc003xvw.2_Missense_Mutation_p.T16S|TRIM55_uc003xvx.2_Missense_Mutation_p.T16S	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	16	RING-type.					cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GAGCAGCAGACCATGGATAAC	0.498													41	74					0	0	0	0	G	67039550	G	G	67039550	3	3	58	1	0	0	0	0	1	0	0	0	16596	507	18	4	49	4	TRIM55	8	67039550	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	9959916	67039550	79324472	296	11681											
E2F5	1875	broad.mit.edu	37	chr8	86114380	86114380	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcgttgtctttcctgaacAggctgctgatactttggctg	5	16	10	10	1	2	2	0	2	2	0	4	2	3	2	1	2	3	4	1	2	2	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:86114380A>T	uc003ycz.3	+	2	272	c.235_splice	c.e2-2	p.A79_splice	E2F5_uc003yda.3_Splice_Site_p.A79_splice|E2F5_uc010mab.2_Splice_Site	NM_001951	NP_001942	Q15329	E2F5_HUMAN	E2F transcription factor 5 isoform 1						G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1						TTTCCTGAACAGGCTGCTGAT	0.348													5	20					0	0	0	0	T	86114380	T	T	86114380	5	4	58	1	0	0	0	0	0	0	1	0	4892	202	7	5	239	5	E2F5	8	86114380	Splice_Site	SNP	A	TCGA-CN-5360-01A-01D-1434-08	19074830	86114380	60249642	297	11682											
CDH17	1015	broad.mit.edu	37	chr8	95183180	95183180	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcttctctttgtcaactaAggaatattgtgcaccgggat	10	13	9	9	1	2	0	1	0	1	0	3	2	2	2	1	2	3	2	1	2	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:95183180A>C	uc003ygh.2	-	8	942	c.817T>G	c.(817-819)TTA>GTA	p.L273V	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Missense_Mutation_p.L273V	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	273	Extracellular (Potential).|Cadherin 3.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TTGTCAACTAAGGAATATTGT	0.453													19	52					0	0	0	0	C	95183180	C	C	95183180	3	2	58	1	0	0	0	0	1	0	0	0	3117	69	3	5	1725	5	CDH17	8	95183180	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	9068800	95183180	51180842	298	11683											
RIMS2	9699	broad.mit.edu	37	chr8	104897854	104897854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atccgaatttggcccgttatCcagtaaagccacaaccctat	12	10	6	13	2	0	0	0	0	0	0	2	1	2	0	5	1	2	2	5	1	6	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:104897854C>T	uc003yls.2	+	2	602	c.361C>T	c.(361-363)CCA>TCA	p.P121S	RIMS2_uc003ylp.2_Missense_Mutation_p.P343S|RIMS2_uc003ylw.2_Missense_Mutation_p.P151S|RIMS2_uc003ylq.2_Missense_Mutation_p.P151S|RIMS2_uc003ylr.2_Missense_Mutation_p.P151S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	374					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGCCCGTTATCCAGTAAAGCC	0.478										HNSCC(12;0.0054)			15	30					0	0	0	0	T	104897854	T	T	104897854	3	4	58	1	0	0	0	0	1	0	0	0	13433	855	30	2	1167	2	RIMS2	8	104897854	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	9714674	104897854	41466168	299	11684											
TM7SF4	81501	broad.mit.edu	37	chr8	105360964	105360964	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgccatcaatcatagcggccGctgcctcctggattatcacg	8	10	9	14	3	3	0	3	0	0	0	4	1	4	1	4	2	3	1	4	2	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:105360964G>A	uc003ylx.1	+	2	233	c.184G>A	c.(184-186)GCT>ACT	p.A62T		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	62	Helical; (Potential).|Poly-Ala.				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CATAGCGGCCGCTGCCTCCTG	0.507													49	84					0	0	0	0	A	105360964	A	A	105360964	3	1	58	1	0	0	0	0	1	0	0	0	16042	1087	38	1	186	1	TM7SF4	8	105360964	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	463110	105360964	41003058	300	11685											
CSMD3	114788	broad.mit.edu	37	chr8	113293570	113293570	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggttcctgggttaccaCactgcacagctataaaacaa	12	10	8	11	0	0	0	0	0	0	0	1	0	1	0	2	2	4	4	2	2	5	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:113293570C>A	uc003ynu.2	-	59	9500	c.9341G>T	c.(9340-9342)TGT>TTT	p.C3114F	CSMD3_uc003yns.2_Missense_Mutation_p.C2316F|CSMD3_uc003ynt.2_Missense_Mutation_p.C3074F|CSMD3_uc011lhx.1_Missense_Mutation_p.C2945F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3114	Extracellular (Potential).|Sushi 23.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGGGTTACCACACTGCACAGC	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	46					5.03518e-11	6.40927e-11	1	0	A	113293570	A	A	113293570	3	1	58	1	0	0	0	0	1	0	0	0	3963	478	17	4	1834	4	CSMD3	8	113293570	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	7932606	113293570	33070452	301	11686											
BAI1	575	broad.mit.edu	37	chr8	143623649	143623649	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtgatcctgcccacggccAcggccacgctgcggcccaag	7	4	12	18	5	0	1	0	1	0	0	1	1	1	1	5	3	2	1	5	3	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:143623649A>T	uc003ywm.2	+	27	4237	c.4054A>T	c.(4054-4056)ACG>TCG	p.T1352S		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1352	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GCCCACGGCCACGGCCACGCT	0.652													20	23					0	0	0	0	T	143623649	T	T	143623649	3	4	58	1	0	0	0	0	1	0	0	0	1300	159	6	5	4160	5	BAI1	8	143623649	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	30330079	143623649	2740373	302	11687											
TIGD5	84948	broad.mit.edu	37	chr8	144681057	144681057	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctcagccgcccgctgctGcggggctggttctttgagga	3	10	16	12	3	2	1	1	1	1	0	2	2	2	2	2	5	3	5	2	5	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:144681057G>T	uc003yyx.1	+	1	837	c.837G>T	c.(835-837)CTG>CTT	p.L279L	EEF1D_uc011lki.1_5'Flank|EEF1D_uc011lkj.1_5'Flank|EEF1D_uc003yyr.2_5'Flank|EEF1D_uc003yyt.2_5'Flank|EEF1D_uc011lkk.1_5'Flank|EEF1D_uc003yys.2_5'Flank|EEF1D_uc003yyv.2_5'Flank|EEF1D_uc003yyu.2_5'Flank|EEF1D_uc011lkl.1_5'Flank	NM_032862	NP_116251	Q53EQ6	TIGD5_HUMAN	tigger transposable element derived 5	328					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GCCCGCTGCTGCGGGGCTGGT	0.697													6	12					0.000157383	0.000168254	1	0	T	144681057	T	T	144681057	2	4	58	1	0	0	0	0	0	0	0	1	15965	1306	46	4		4	TIGD5	8	144681057	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1057408	144681057	1682965	303	11688											
PLEC	5339	broad.mit.edu	37	chr8	145049407	145049407	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcccgttgctcccagcgccaCccccgctgcgccggctccgc	2	6	10	23	6	0	0	0	0	0	0	3	0	3	0	7	1	3	4	7	1	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:145049407C>T	uc003zaj.2	-	2	180	c.131G>A	c.(130-132)GGT>GAT	p.G44D	PLEC_uc003zah.2_5'Flank	NM_000445	NP_000436	Q15149	PLEC_HUMAN	plectin isoform 1c	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCCAGCGCCACCCCCGCTGCG	0.657											OREG0019050	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	50					0	0	0	0	T	145049407	T	T	145049407	3	4	58	1	0	0	0	0	1	0	0	0	12107	507	18	4	14752	4	PLEC	8	145049407	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	368350	145049407	1314615	304	11689											
FREM1	158326	broad.mit.edu	37	chr9	14812864	14812864	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atctctctgagagaactgatCcactgtgactccagctctcc	9	11	7	14	0	3	4	0	3	3	1	7	5	5	4	3	0	2	1	3	0	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:14812864C>G	uc003zlm.2	-	16	3429	c.2839G>C	c.(2839-2841)GAT>CAT	p.D947H	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	947	CSPG 6.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GAGAACTGATCCACTGTGACT	0.488													70	147					0	0	0	0	G	14812864	G	G	14812864	3	3	58	1	0	0	0	0	1	0	0	0	6078	855	30	2	3838	2	FREM1	9	14812864	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08		14812864	126400567	305	11690											
CDKN2A	1029	broad.mit.edu	37	chr9	21974693	21974693	+	Frame_Shift_Del	DEL	C	-	-																															ccacctggatcggcctccgaCcgtaactattcggtgcgttg																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:21974693delC	uc003zpk.2	-	1	346	c.134delG	c.(133-135)GGTfs	p.G45fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Frame_Shift_Del_p.G45fs|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	45	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(25)|p.G45fs*8(3)|p.G45D(2)|p.G45S(1)|p.V28_V51del(1)|p.G45del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGGCCTCCGACCGTAACTATT	0.687		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---								-	21974693	-	-	21974693	7	5	58	1	0	1	0	1	0	0	0	0	3176	507	18	0	549	0	CDKN2A	9	21974693	Frame_Shift_Del	DEL	C	TCGA-CN-5360-01A-01D-1434-08	7161829	21974693	119238738	306	11691											
C9orf135	138255	broad.mit.edu	37	chr9	72459432	72459432	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gactcctaattttttcttaaGgcaccgtgacagagaagctt	11	13	8	9	1	1	2	0	1	1	1	2	4	2	2	2	1	1	2	2	1	3	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:72459432G>T	uc004ahl.2	+	2	218	c.153_splice	c.e2-1	p.W51_splice	C9orf135_uc011lrw.1_Intron|C9orf135_uc010moq.2_Intron|C9orf135_uc011lrx.1_Intron|C9orf135_uc010mop.2_Splice_Site_p.W51_splice	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255							integral to membrane				ovary(1)	1						TTTTTCTTAAGGCACCGTGAC	0.328													23	82					3.28513e-13	4.31886e-13	1	0	T	72459432	T	T	72459432	5	4	58	1	0	0	0	0	0	0	1	0	2470	1014	35	4	158	4	C9orf135	9	72459432	Splice_Site	SNP	G	TCGA-CN-5360-01A-01D-1434-08	50484739	72459432	68753999	307	11692											
TMEM2	23670	broad.mit.edu	37	chr9	74360468	74360468	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtaatatttctggatccaTctttattgtccccaaataca	13	15	4	9	0	2	0	0	0	2	0	4	1	4	1	3	1	1	1	3	1	6	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:74360468T>C	uc011lsa.1	-	4	1040	c.500A>G	c.(499-501)GAT>GGT	p.D167G	TMEM2_uc010mos.2_Missense_Mutation_p.D167G|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	167	G8.					integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TCTGGATCCATCTTTATTGTC	0.423													27	98					0	0	0	0	C	74360468	C	C	74360468	3	2	58	1	0	0	0	0	1	0	0	0	16187	1435	50	5	3735	5	TMEM2	9	74360468	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1901036	74360468	66852963	308	11693											
C9orf41	138199	broad.mit.edu	37	chr9	77599914	77599914	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgccagattttcaaagtggTacagcagaggacctatggtt	11	12	11	7	0	1	2	1	0	0	2	1	3	1	3	2	3	3	3	2	3	3	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:77599914T>A	uc004ajq.2	-	7	1190	c.1037A>T	c.(1036-1038)TAC>TTC	p.Y346F	uc004ajp.2_Intron|C9orf41_uc011lsi.1_RNA	NM_152420	NP_689633	Q8N4J0	CI041_HUMAN	hypothetical protein LOC138199	346										ovary(1)|skin(1)	2						TTCAAAGTGGTACAGCAGAGG	0.348													26	69					0	0	0	0	A	77599914	A	A	77599914	3	1	58	1	0	0	0	0	1	0	0	0	2494	1638	57	5	200	5	C9orf41	9	77599914	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	3239446	77599914	63613517	309	11694											
FLJ46321	389763	broad.mit.edu	37	chr9	84608996	84608996	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcataccttaaaaatcagaTgttgagccagttaaagttgg	15	12	8	6	0	2	2	2	1	0	1	2	2	2	2	2	1	2	3	2	1	6	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:84608996T>C	uc004amn.2	+	4	3658	c.3611T>C	c.(3610-3612)ATG>ACG	p.M1204T		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1204						integral to membrane					0						AAAAATCAGATGTTGAGCCAG	0.393													25	98					0	0	0	0	C	84608996	C	C	84608996	3	2	58	1	0	0	0	0	1	0	0	0	5964	1464	51	5	3625	5	FLJ46321	9	84608996	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	7009082	84608996	56604435	310	11695											
FLJ46321	389763	broad.mit.edu	37	chr9	84610013	84610013	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggtgtgtccagccgtccCaaccagtgctaaaagccctg	8	8	10	15	1	0	0	0	0	0	0	2	0	2	0	6	1	4	1	6	1	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:84610013C>G	uc004amn.2	+	4	4675	c.4628C>G	c.(4627-4629)CCA>CGA	p.P1543R		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1543						integral to membrane					0						CCAGCCGTCCCAACCAGTGCT	0.527													5	26					0	0	0	0	G	84610013	G	G	84610013	3	3	58	1	0	0	0	0	1	0	0	0	5964	594	21	4	4642	4	FLJ46321	9	84610013	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1017	84610013	56603418	311	11696											
OR13C5	138799	broad.mit.edu	37	chr9	107360955	107360955	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccacagaatgttatcaccAcagtcagacgagctgagcag	13	7	9	12	1	2	3	2	1	0	2	3	4	3	3	2	0	2	3	2	0	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:107360955A>C	uc011lvp.1	-	1	740	c.740T>G	c.(739-741)GTG>GGG	p.V247G		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TGTTATCACCACAGTCAGACG	0.423													23	77					0	0	0	0	C	107360955	C	C	107360955	3	2	58	1	0	0	0	0	1	0	0	0	10991	159	6	5	218	5	OR13C5	9	107360955	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	22750942	107360955	33852476	312	11697											
SVEP1	79987	broad.mit.edu	37	chr9	113261433	113261433	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggcaacttacatagcagatCgtcccaaatttggctggctg	10	10	10	11	2	0	1	0	0	0	1	2	1	1	1	1	3	3	4	1	3	4	3	rs3737156	by1000genomes	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:113261433C>T	uc010mtz.2	-	7	1906	c.1569G>A	c.(1567-1569)ACG>ACA	p.T523T	SVEP1_uc010mua.1_Silent_p.T523T|SVEP1_uc004beu.2_Silent_p.T523T	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	523	Sushi 3.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CATAGCAGATCGTCCCAAATT	0.488													18	44					0	0	0	0	T	113261433	T	T	113261433	2	4	58	1	0	0	0	0	0	0	0	1	15486	871	31	1		1	SVEP1	9	113261433	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5900478	113261433	27951998	313	11698											
PAPPA	5069	broad.mit.edu	37	chr9	118950444	118950444	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtggagagtgctgtgaccCtgaaatcaccaatgtcactc	10	10	11	10	0	2	3	2	2	0	1	3	4	2	3	2	2	1	1	2	2	2	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:118950444C>G	uc004bjn.2	+	2	1808	c.1427C>G	c.(1426-1428)CCT>CGT	p.P476R	PAPPA_uc011lxp.1_Missense_Mutation_p.P269R|PAPPA_uc011lxq.1_Missense_Mutation_p.P269R	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	476	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TGCTGTGACCCTGAAATCACC	0.507													13	44					0	0	0	0	G	118950444	G	G	118950444	3	3	58	1	0	0	0	0	1	0	0	0	11486	681	24	4	1433	4	PAPPA	9	118950444	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5689011	118950444	22262987	314	11699											
C5	727	broad.mit.edu	37	chr9	123776180	123776180	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaattgcatgtctttatgaGagatattagcacggagctgg	11	12	11	7	1	1	2	0	1	1	1	1	4	1	3	1	2	3	3	1	2	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:123776180G>C	uc004bkv.2	-	17	2258	c.2228C>G	c.(2227-2229)TCT>TGT	p.S743C	C5_uc010mvm.1_Missense_Mutation_p.S743C	NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	743					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	GTCTTTATGAGAGATATTAGC	0.423													42	125					0	0	0	0	C	123776180	C	C	123776180	3	2	58	1	0	0	0	0	1	0	0	0	2290	942	33	2	2902	2	C5	9	123776180	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	4825736	123776180	17437251	315	11700											
MRRF	92399	broad.mit.edu	37	chr9	125084837	125084837	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatcagccaaatggccgatGacacagtggcagaactggac	14	5	12	10	1	1	3	1	1	0	2	1	5	1	4	2	3	2	1	2	3	2	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:125084837G>A	uc004bmb.2	+	7	845	c.730G>A	c.(730-732)GAC>AAC	p.D244N	MRRF_uc004bmc.2_Missense_Mutation_p.M190I|MRRF_uc010mwa.2_Missense_Mutation_p.D244N|MRRF_uc011lyr.1_Missense_Mutation_p.D192N|MRRF_uc004bmd.2_Missense_Mutation_p.D244N|MRRF_uc004bme.2_RNA	NM_138777	NP_620132	Q96E11	RRFM_HUMAN	mitochondrial ribosome recycling factor isoform	244					ribosome disassembly|translation	mitochondrion	sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						AATGGCCGATGACACAGTGGC	0.493													7	33					0	0	0	0	A	125084837	A	A	125084837	3	1	58	1	0	0	0	0	1	0	0	0	9903	1290	45	2	752	2	MRRF	9	125084837	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1308657	125084837	16128594	316	11701											
GOLGA1	2800	broad.mit.edu	37	chr9	127670691	127670691	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttaatggccttagcctggcTgcttctggctgccaagagct	6	12	12	11	0	1	1	0	0	1	1	1	1	1	1	3	3	4	5	3	3	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:127670691T>C	uc004bpc.2	-	12	1372	c.1030A>G	c.(1030-1032)AGC>GGC	p.S344G	GOLGA1_uc010mws.2_RNA	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	344	Potential.					Golgi cisterna membrane				ovary(1)	1						TTAGCCTGGCTGCTTCTGGCT	0.463													33	130					0	0	0	0	C	127670691	C	C	127670691	3	2	58	1	0	0	0	0	1	0	0	0	6588	1580	55	5	1321	5	GOLGA1	9	127670691	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	2585854	127670691	13542740	317	11702											
RPL12	6136	broad.mit.edu	37	chr9	130210254	130210255	+	Frame_Shift_Del	DEL	TC	-	-																															tgactgggcagtccccaggaTctctttaatggttcctttaa																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:130210254_130210255delTC	uc004bqy.1	-	6	481_482	c.393_394delGA	c.(391-396)GAGATCfs	p.E131fs	RPL12_uc004bqx.1_RNA|RPL12_uc004bqz.1_Frame_Shift_Del_p.E98fs	NM_000976	NP_000967	P30050	RL12_HUMAN	ribosomal protein L12	131_132					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						GTCCCCAGGATCTCTTTAATGG	0.505													---	---	---								-	130210255	-	-	130210254	7	5	58	1	0	1	0	1	0	0	0	0	13623	1435	50	0	111	0	RPL12	9	130210254	Frame_Shift_Del	DEL	TC	TCGA-CN-5360-01A-01D-1434-08	2539563	130210254	11003177	318	11703											
C9orf98	158067	broad.mit.edu	37	chr9	135602855	135602855	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaacctttccccagtgacTggatcaattcttctcagagt	11	12	6	12	0	3	2	2	1	2	1	5	3	4	3	3	1	1	0	3	1	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:135602855T>A	uc004cbu.1	-	12	1744	c.1188A>T	c.(1186-1188)CCA>CCT	p.P396P	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_Silent_p.P192P	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	396	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		CCCCAGTGACTGGATCAATTC	0.463													34	113					0	0	0	0	A	135602855	A	A	135602855	2	1	58	1	0	0	0	0	0	0	0	1	2521	1567	55	5		5	C9orf98	9	135602855	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	5392601	135602855	5610576	319	11704											
SARDH	1757	broad.mit.edu	37	chr9	136597649	136597649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcccgtctcctcctccagctCccggctcaccacccgccgag	4	7	7	23	4	2	0	1	0	1	0	7	1	6	0	8	1	1	2	8	1	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:136597649C>T	uc004cep.3	-	3	540	c.406G>A	c.(406-408)GAG>AAG	p.E136K	SARDH_uc004ceo.2_Missense_Mutation_p.E136K|SARDH_uc011mdn.1_Missense_Mutation_p.E136K|SARDH_uc011mdo.1_5'UTR	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	136					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TCCTCCAGCTCCCGGCTCACC	0.672													29	139					0	0	0	0	T	136597649	T	T	136597649	3	4	58	1	0	0	0	0	1	0	0	0	13906	864	30	2	2426	2	SARDH	9	136597649	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	994794	136597649	4615782	320	11705											
SARDH	1757	broad.mit.edu	37	chr9	136599210	136599210	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctgtggggccagctgcgctgGacaggttgcatggccccatg	5	8	16	12	1	0	0	0	0	0	0	0	1	0	1	3	5	3	4	3	5	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:136599210G>C	uc004cep.3	-	2	220	c.86C>G	c.(85-87)TCC>TGC	p.S29C	SARDH_uc004ceo.2_Missense_Mutation_p.S29C|SARDH_uc011mdn.1_Missense_Mutation_p.S29C|SARDH_uc011mdo.1_Intron	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	29					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		AGCTGCGCTGGACAGGTTGCA	0.697													8	35					0	0	0	0	C	136599210	C	C	136599210	3	2	58	1	0	0	0	0	1	0	0	0	13906	1174	41	2	2750	2	SARDH	9	136599210	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1561	136599210	4614221	321	11706											
COL5A1	1289	broad.mit.edu	37	chr9	137653806	137653806	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccggcccaccaggacctccGggagacgatggagaaagggt	10	4	15	12	3	0	2	0	0	0	2	2	6	2	3	5	5	0	0	5	5	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:137653806G>C	uc004cfe.2	+	19	2353	c.1971G>C	c.(1969-1971)CCG>CCC	p.P657P		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	657	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CAGGACCTCCGGGAGACGATG	0.597													23	81					0	0	0	0	C	137653806	C	C	137653806	2	2	58	1	0	0	0	0	0	0	0	1	3711	1103	39	3		3	COL5A1	9	137653806	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1054596	137653806	3559625	322	11707											
CLIC3	9022	broad.mit.edu	37	chr9	139889998	139889998	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgcgagccgggggcgaaGtccttcagcacgtccgggga	7	5	17	12	5	1	0	1	0	0	0	3	3	3	1	3	4	4	2	3	4	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:139889998G>A	uc004ckj.1	-	3	194	c.165C>T	c.(163-165)GAC>GAT	p.D55D		NM_004669	NP_004660	O95833	CLIC3_HUMAN	chloride intracellular channel 3	55	GST N-terminal.|Required for insertion into the membrane (By similarity).				signal transduction	chloride channel complex|cytoplasm|nucleus	protein binding|voltage-gated chloride channel activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGGGGGCGAAGTCCTTCAGCA	0.697													13	64					0	0	0	0	A	139889998	A	A	139889998	2	1	58	1	0	0	0	0	0	0	0	1	3542	1020	36	4		4	CLIC3	9	139889998	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2236192	139889998	1323433	323	11708											
ITGA8	8516	broad.mit.edu	37	chr10	15649735	15649735	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgcctttttatcacaagagGgaagacgcgatgagcctgat	11	10	11	9	2	1	4	1	2	0	2	1	6	1	5	2	1	2	0	2	1	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:15649735G>T	uc001ioc.1	-	17	1705	c.1705C>A	c.(1705-1707)CCT>ACT	p.P569T	ITGA8_uc010qcb.1_Missense_Mutation_p.P554T	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	569	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						ATCACAAGAGGGAAGACGCGA	0.448													64	135					2.67592e-24	4.09506e-24	1	0	T	15649735	T	T	15649735	3	4	58	1	0	0	0	0	1	0	0	0	7921	1232	43	4	1542	4	ITGA8	10	15649735	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08		15649735	119885012	324	11709											
SLC39A12	221074	broad.mit.edu	37	chr10	18242223	18242223	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaatgtgcttccggacaaaGctctcagtatcctgggtgcc	9	10	11	11	1	1	0	1	0	1	0	4	2	3	1	3	2	3	3	3	2	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:18242223G>T	uc001ipo.2	+	2	291	c.18G>T	c.(16-18)AAG>AAT	p.K6N	SLC39A12_uc001ipn.2_Missense_Mutation_p.K6N|SLC39A12_uc001ipp.2_Missense_Mutation_p.K6N|SLC39A12_uc010qck.1_Intron	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	6	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TCCGGACAAAGCTCTCAGTAT	0.493													22	67					2.89027e-11	3.69282e-11	1	0	T	18242223	T	T	18242223	3	4	58	1	0	0	0	0	1	0	0	0	14679	962	34	4	20	4	SLC39A12	10	18242223	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2592488	18242223	117292524	325	11710											
ARHGAP12	94134	broad.mit.edu	37	chr10	32141445	32141445	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggtgtcaaggtttattacCtttggcaattcccattctga	8	16	8	9	1	2	1	1	1	1	0	4	1	3	1	2	3	1	2	2	3	4	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:32141445C>A	uc001ivz.1	-	6	1440	c.1170G>T	c.(1168-1170)AAG>AAT	p.K390N	ARHGAP12_uc001ivy.1_Missense_Mutation_p.K341N|ARHGAP12_uc009xls.2_Missense_Mutation_p.K341N|ARHGAP12_uc001iwb.1_Missense_Mutation_p.K388N|ARHGAP12_uc001iwc.1_Missense_Mutation_p.K388N|ARHGAP12_uc009xlq.1_Missense_Mutation_p.K341N|ARHGAP12_uc001iwd.1_Missense_Mutation_p.K388N|ARHGAP12_uc009xlr.1_Missense_Mutation_p.K388N	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	390	WW 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				GGTTTATTACCTTTGGCAATT	0.348													44	80					5.2432e-18	7.37732e-18	1	0	A	32141445	A	A	32141445	3	1	58	1	0	0	0	0	1	0	0	0	865	695	24	4	1430	4	ARHGAP12	10	32141445	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	13899222	32141445	103393302	326	11711											
ZNF37A	7587	broad.mit.edu	37	chr10	38406775	38406775	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagttaaatctcactccAattcagagaacccactcaat	16	9	4	12	0	3	2	3	0	1	2	5	3	4	2	2	0	1	1	2	0	6	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:38406775A>G	uc001izk.2	+	8	1515	c.696A>G	c.(694-696)CCA>CCG	p.P232P	ZNF37A_uc001izl.2_Silent_p.P232P|ZNF37A_uc001izm.2_Silent_p.P232P	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	232						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						ATCTCACTCCAATTCAGAGAA	0.338													10	45					0	0	0	0	G	38406775	G	G	38406775	2	3	58	1	0	0	0	0	0	0	0	1	17939	117	5	5		5	ZNF37A	10	38406775	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	6265330	38406775	97127972	327	11712											
OGDHL	55753	broad.mit.edu	37	chr10	50954889	50954889	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tataccacgccctggccagcAaaggcggcgtccccatgaac	10	5	10	16	3	0	1	0	1	0	0	1	1	1	1	5	3	3	1	5	3	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:50954889A>C	uc001jie.2	-	10	1345	c.1203T>G	c.(1201-1203)TTT>TTG	p.F401L	OGDHL_uc009xog.2_Missense_Mutation_p.F428L|OGDHL_uc010qgt.1_Missense_Mutation_p.F344L|OGDHL_uc010qgu.1_Missense_Mutation_p.F192L|OGDHL_uc009xoh.2_Missense_Mutation_p.F192L	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	401					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						CCTGGCCAGCAAAGGCGGCGT	0.637													10	34					0	0	0	0	C	50954889	C	C	50954889	3	2	58	1	0	0	0	0	1	0	0	0	10894	127	5	5	1885	5	OGDHL	10	50954889	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	12548114	50954889	84579858	328	11713											
RBP4	5950	broad.mit.edu	37	chr10	95360467	95360467	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgtggcgctcatctggcCggtctcgtccacggagaact	5	9	14	13	4	3	1	1	0	2	1	5	2	4	1	2	5	1	2	2	5	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:95360467C>A	uc001kit.2	-	3	289	c.205G>T	c.(205-207)GGC>TGC	p.G69C		NM_006744	NP_006735	P02753	RET4_HUMAN	retinol-binding protein 4, plasma precursor	69					cardiac muscle tissue development|embryonic organ morphogenesis|embryonic retina morphogenesis in camera-type eye|embryonic skeletal system development|female genitalia morphogenesis|gluconeogenesis|glucose homeostasis|heart trabecula formation|lung development|maintenance of gastrointestinal epithelium|negative regulation of cardiac muscle cell proliferation|positive regulation of immunoglobulin secretion|positive regulation of insulin secretion|response to retinoic acid|retinol metabolic process|urinary bladder development|uterus development|vagina development	extracellular space	protein binding|retinal binding|retinol binding				0		Colorectal(252;0.122)			Vitamin A(DB00162)	CTCATCTGGCCGGTCTCGTCC	0.647													9	10					5.4927e-09	6.53939e-09	1	0	A	95360467	A	A	95360467	3	1	58	1	0	0	0	0	1	0	0	0	13223	652	23	3	416	3	RBP4	10	95360467	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	44405578	95360467	40174280	329	11714											
PNLIPRP2	5408	broad.mit.edu	37	chr10	118383495	118383495	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaacttggctgcttttctgAtgaaaaaccatgggcaggaa	13	10	10	8	0	1	2	0	2	1	0	1	3	1	3	1	3	3	3	1	3	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:118383495A>T	uc001lcq.2	+	5	115	c.92A>T	c.(91-93)GAT>GTT	p.D31V	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	30					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		TGCTTTTCTGATGAAAAACCA	0.463													23	39					0	0	0	0	T	118383495	T	T	118383495	3	4	58	1	0	0	0	0	1	0	0	0	12206	333	12	5	101	5	PNLIPRP2	10	118383495	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	23023028	118383495	17151252	330	11715											
FAM196A	642938	broad.mit.edu	37	chr10	128974171	128974171	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcttgtgcacccgccccgcGccacatggccgggcctcctc	3	7	11	20	4	1	0	0	0	1	0	3	0	2	0	7	2	1	1	7	2	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:128974171G>C	uc001lju.1	-	1	530	c.489C>G	c.(487-489)GGC>GGG	p.G163G	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Silent_p.G163G|FAM196A_uc001ljv.1_Silent_p.G163G|FAM196A_uc009yap.1_Silent_p.G163G	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	163										ovary(2)	2						CCCGCCCCGCGCCACATGGCC	0.552													22	53					0	0	0	0	C	128974171	C	C	128974171	2	2	58	1	0	0	0	0	0	0	0	1	5556	1074	38	3		3	FAM196A	10	128974171	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	10590676	128974171	6560576	331	11716											
FRG2B	441581	broad.mit.edu	37	chr10	135438781	135438781	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaatacaaggtctgcaccTgggcacacagaggcccccgg	10	5	13	13	1	1	1	0	0	1	1	1	2	1	2	3	5	2	2	3	5	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:135438781T>C	uc010qvg.1	-	4	712	c.659A>G	c.(658-660)CAG>CGG	p.Q220R		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	220						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GGTCTGCACCTGGGCACACAG	0.597													10	21					0	0	0	0	C	135438781	C	C	135438781	3	2	58	1	0	0	0	0	1	0	0	0	6081	1580	55	5	180	5	FRG2B	10	135438781	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	6464610	135438781	95966	332	11717											
SIGIRR	59307	broad.mit.edu	37	chr11	408879	408879	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cggggagaggaagtcaggggCcctatcacagacacctgaag	12	4	15	10	1	2	3	2	1	0	2	2	5	2	4	2	5	0	0	2	5	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:408879C>T	uc001lpd.2	-	3	352	c.22G>A	c.(22-24)GCC>ACC	p.A8T	SIGIRR_uc001lpf.2_Missense_Mutation_p.A8T|SIGIRR_uc001lpe.1_Missense_Mutation_p.A8T|SIGIRR_uc001lpg.2_Missense_Mutation_p.A8T	NM_001135054	NP_001128526	Q6IA17	SIGIR_HUMAN	single Ig IL-1R-related molecule	8	Extracellular (Potential).				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity				0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAGTCAGGGGCCCTATCACAG	0.617													14	48					0	0	0	0	T	408879	T	T	408879	3	4	58	1	0	0	0	0	1	0	0	0	14369	739	26	4	1242	4	SIGIRR	11	408879	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08		408879	134597637	333	11718											
MUC5B	727897	broad.mit.edu	37	chr11	1255445	1255445	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtccccagggtgtgcagcCcccatggtgtacctggactg	5	9	13	14	0	0	0	0	0	0	0	1	1	1	1	5	3	3	2	5	3	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:1255445C>A	uc009ycr.1	+	36	4491	c.4365C>A	c.(4363-4365)GCC>GCA	p.A1455A	MUC5B_uc009yct.1_Silent_p.A796A|MUC5B_uc001ltb.2_Silent_p.A799A|MUC5B_uc001lta.2_Silent_p.A464A	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	796					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGTGTGCAGCCCCCATGGTGT	0.682													3	6					0.00024832	0.000264228	1	0	A	1255445	A	A	1255445	2	1	58	1	0	0	0	0	0	0	0	1	10032	610	22	4		4	MUC5B	11	1255445	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	846566	1255445	133751071	334	11719											
MUC5B	727897	broad.mit.edu	37	chr11	1268010	1268010	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaccccctcctccaccccAggaacagctcacactaccaa	11	4	4	22	0	1	0	1	0	0	0	3	1	3	1	8	1	3	1	8	1	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:1268010A>C	uc009ycr.1	+	49	11775	c.11649A>C	c.(11647-11649)CCA>CCC	p.P3883P	MUC5B_uc001ltb.2_Silent_p.P3303P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3300	7 X Cys-rich subdomain repeats.|Thr-rich.|17 X approximate tandem repeats, Ser/Thr- rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCTCCACCCCAGGAACAGCTC	0.637													3	64					0	0	0	0	C	1268010	C	C	1268010	2	2	58	1	0	0	0	0	0	0	0	1	10032	175	7	5		5	MUC5B	11	1268010	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	12565	1268010	133738506	335	11720											
MUC5B	727897	broad.mit.edu	37	chr11	1269681	1269681	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaccccctcttccaccccAggaacagctcacactaccaa	11	5	4	21	0	2	0	1	0	1	0	3	1	3	1	7	1	3	1	7	1	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:1269681A>C	uc009ycr.1	+	50	13281	c.13155A>C	c.(13153-13155)CCA>CCC	p.P4385P	MUC5B_uc001ltb.2_Silent_p.P3860P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3857	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTTCCACCCCAGGAACAGCTC	0.647													11	27					0	0	0	0	C	1269681	C	C	1269681	2	2	58	1	0	0	0	0	0	0	0	1	10032	175	7	5		5	MUC5B	11	1269681	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	1671	1269681	133736835	336	11721											
ZNF195	7748	broad.mit.edu	37	chr11	3381036	3381036	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctccaatctcatttctcTggtgtttggaaggatttggg	6	16	10	9	0	2	0	1	0	2	0	6	2	4	2	2	4	0	1	2	4	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:3381036T>C	uc001lxt.2	-	6	1380	c.1202A>G	c.(1201-1203)CAG>CGG	p.Q401R	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Missense_Mutation_p.Q378R|ZNF195_uc001lxs.2_Missense_Mutation_p.Q329R|ZNF195_uc010qxr.1_Missense_Mutation_p.Q382R|ZNF195_uc009ydz.2_Missense_Mutation_p.Q356R|ZNF195_uc001lxu.2_Missense_Mutation_p.Q333R	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	401				Missing (in Ref. 2; BAD18466).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		CTCATTTCTCTGGTGTTTGGA	0.408													81	239					0	0	0	0	C	3381036	C	C	3381036	3	2	58	1	0	0	0	0	1	0	0	0	17825	1580	55	5	691	5	ZNF195	11	3381036	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	2111355	3381036	131625480	337	11722											
HBE1	3046	broad.mit.edu	37	chr11	5290723	5290723	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acatgcagcttgtcacagtgCagctcactcagcttagcaaa	12	9	8	12	0	3	0	3	0	0	0	3	0	3	0	0	0	6	6	0	0	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:5290723C>A	uc001mal.1	-	2	529	c.276G>T	c.(274-276)CTG>CTT	p.L92L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Silent_p.L92L	NM_005330	NP_005321	P02100	HBE_HUMAN	epsilon globin	92					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTCACAGTGCAGCTCACTCA	0.458													33	135					6.53348e-20	9.54785e-20	1	0	A	5290723	A	A	5290723	2	1	58	1	0	0	0	0	0	0	0	1	7019	697	25	4		4	HBE1	11	5290723	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1909687	5290723	129715793	338	11723											
OR51M1	390059	broad.mit.edu	37	chr11	5411012	5411012	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggagtcctcagtgctcctCatgatgtcctttgaccgcct	6	13	9	13	1	2	2	2	2	0	0	5	3	5	3	5	1	1	1	5	1	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:5411012C>T	uc010qzc.1	+	1	384	c.384C>T	c.(382-384)CTC>CTT	p.L128L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	128						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGTGCTCCTCATGATGTCCT	0.488													82	307					0	0	0	0	T	5411012	T	T	5411012	2	4	58	1	0	0	0	0	0	0	0	1	11157	813	29	2		2	OR51M1	11	5411012	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	120289	5411012	129595504	339	11724											
OR56A4	120793	broad.mit.edu	37	chr11	6024019	6024019	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acgatgtccagcagggagagGaggctgagcaggtagtacag	12	5	17	7	1	0	2	0	1	0	1	1	5	1	3	1	4	3	5	1	4	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:6024019G>A	uc010qzv.1	-	1	360	c.360C>T	c.(358-360)CTC>CTT	p.L120L		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAGGGAGAGGAGGCTGAGCA	0.607													25	85					0	0	0	0	A	6024019	A	A	6024019	2	1	58	1	0	0	0	0	0	0	0	1	11189	1161	41	2		2	OR56A4	11	6024019	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	613007	6024019	128982497	340	11725											
OR2AG2	338755	broad.mit.edu	37	chr11	6789565	6789565	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaatggcagaaatggggagCaagaggaaagtcacacctgt	16	5	13	7	0	1	2	1	0	0	2	1	4	1	4	1	4	1	2	1	4	4	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:6789565C>A	uc001meq.1	-	1	624	c.624G>T	c.(622-624)TTG>TTT	p.L208F		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAATGGGGAGCAAGAGGAAAG	0.502													10	34					0.00829132	0.00852929	1	0	A	6789565	A	A	6789565	3	1	58	1	0	0	0	0	1	0	0	0	11039	709	25	4	330	4	OR2AG2	11	6789565	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	765546	6789565	128216951	341	11726											
EIF3F	8665	broad.mit.edu	37	chr11	8008811	8008811	+	5'Flank	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaccaatcagcaaaaagctcTagctcacgtggtgtatattc	14	10	7	10	1	3	0	2	0	1	0	4	0	3	0	1	1	4	4	1	1	7	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:8008811T>C	uc001mfw.2	+						EIF3F_uc010rbj.1_5'UTR	NM_003754	NP_003745	O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3,							cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(1)	1				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAAAAAGCTCTAGCTCACGTG	0.478											OREG0020726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	180					0	0	0	0	C	8008811	C	C	8008811	1	2	58	0	1	0	0	0	0	0	0	0	5040	1537	53	5		5	EIF3F	11	8008811	5'Flank	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1219246	8008811	126997705	342	11727											
ANO5	203859	broad.mit.edu	37	chr11	22294481	22294481	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcttctaaagctcatagcatAggtgtttggcaagacattct	11	13	9	8	0	3	1	1	0	2	1	3	1	3	1	0	2	2	5	0	2	5	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:22294481A>T	uc001mqi.2	+	19	2498	c.2181A>T	c.(2179-2181)ATA>ATT	p.I727I	ANO5_uc001mqj.2_Silent_p.I726I	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	727	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						CTCATAGCATAGGTGTTTGGC	0.403													42	144					0	0	0	0	T	22294481	T	T	22294481	2	4	58	1	0	0	0	0	0	0	0	1	700	410	15	5		5	ANO5	11	22294481	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	14285670	22294481	112712035	343	11728											
KCNA4	3739	broad.mit.edu	37	chr11	30033431	30033431	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcctcccgaaacttcaacagGgcctcctcccccaactgata	10	8	5	18	1	1	1	1	1	0	0	5	2	5	1	6	1	3	0	6	1	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:30033431G>T	uc001msk.2	-	2	1947	c.795C>A	c.(793-795)GCC>GCA	p.A265A		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	265						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACTTCAACAGGGCCTCCTCCC	0.488													40	103					1.04594e-18	1.48702e-18	1	0	T	30033431	T	T	30033431	2	4	58	1	0	0	0	0	0	0	0	1	8044	1219	43	4		4	KCNA4	11	30033431	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	7738950	30033431	104973085	344	11729											
LRRC4C	57689	broad.mit.edu	37	chr11	40136727	40136727	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggaggcccgacatttcagCtcagctgccatgccttcagt	7	10	11	13	1	3	0	3	0	0	0	3	2	3	1	3	2	4	2	3	2	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:40136727C>A	uc001mxa.1	-	2	3080	c.1116G>T	c.(1114-1116)GAG>GAT	p.E372D	LRRC4C_uc001mxc.1_Missense_Mutation_p.E368D|LRRC4C_uc001mxd.1_Missense_Mutation_p.E368D|LRRC4C_uc001mxb.1_Missense_Mutation_p.E368D	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	372	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GACATTTCAGCTCAGCTGCCA	0.517													28	60					2.81731e-10	3.50108e-10	1	0	A	40136727	A	A	40136727	3	1	58	1	0	0	0	0	1	0	0	0	9058	796	28	4	810	4	LRRC4C	11	40136727	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	10103296	40136727	94869789	345	11730											
ALX4	60529	broad.mit.edu	37	chr11	44296974	44296974	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtctgggtagtgggtcttcTggaagaccttctccagctcc	5	12	12	12	1	4	1	0	0	4	1	6	2	5	2	3	3	1	2	3	3	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:44296974T>A	uc001myb.2	-	2	805	c.701A>T	c.(700-702)CAG>CTG	p.Q234L		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	234	Homeobox.				hair follicle development						0						GTGGGTCTTCTGGAAGACCTT	0.617													89	220					0	0	0	0	A	44296974	A	A	44296974	3	1	58	1	0	0	0	0	1	0	0	0	558	1580	55	5	546	5	ALX4	11	44296974	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	4160247	44296974	90709542	346	11731											
OR4A5	81318	broad.mit.edu	37	chr11	51411677	51411678	+	Missense_Mutation	DNP	CC	AA	AA																															agaggacaacaacggtactgCcggagctgcaggtagacaag																								rs5011055	byFrequency	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:51411677_51411678CC>AA	uc001nhi.1	-	1	718_719	c.718_719GG>TT	c.(718-720)GGC>TTC	p.G240F		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				AACGGTACTGCCGGAGCTGCAG	0.401													5	65					0	0	0	0	AA	51411678	AA	AA	51411677	3	1	58	1	0	0	0	0	1	0	0	0	11097	739	26	4	232	4	OR4A5	11	51411677	Missense_Mutation	DNP	CC	TCGA-CN-5360-01A-01D-1434-08	7114703	51411677	83594839	347	11732											
OR5L1	219437	broad.mit.edu	37	chr11	55579236	55579237	+	Missense_Mutation	DNP	GG	TT	TT																															atctccttcctagggtgcatGgtgcaattctacttgttttg																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:55579236_55579237GG>TT	uc001nhw.1	+	1	294_295	c.294_295GG>TT	c.(292-297)ATGGTG>ATTTTG	p.98_99MV>IL		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	98_99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TAGGGTGCATGGTGCAATTCTA	0.45													29	251					0	0	0	0	TT	55579237	TT	TT	55579236	3	4	58	1	0	0	0	0	1	0	0	0	11224	1348	47	4	296	4	OR5L1	11	55579236	Missense_Mutation	DNP	GG	TCGA-CN-5360-01A-01D-1434-08	4167559	55579236	79427280	348	11733											
OR5D18	219438	broad.mit.edu	37	chr11	55587970	55587970	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatccccatgttgaatcccCtgatctacagtctgagaaat	11	12	7	11	0	2	4	0	4	2	1	4	5	4	4	4	0	1	1	4	0	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:55587970C>A	uc010rin.1	+	1	865	c.865C>A	c.(865-867)CTG>ATG	p.L289M		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GTTGAATCCCCTGATCTACAG	0.458													7	70					8.12818e-05	8.70329e-05	1	0	A	55587970	A	A	55587970	3	1	58	1	0	0	0	0	1	0	0	0	11211	680	24	4	867	4	OR5D18	11	55587970	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	8734	55587970	79418546	349	11734											
OR5L2	26338	broad.mit.edu	37	chr11	55594988	55594989	+	Missense_Mutation	DNP	GG	TT	TT																															atctccttcctagggtgcatGgtgcaattctacttgttttg																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:55594988_55594989GG>TT	uc001nhy.1	+	1	294_295	c.294_295GG>TT	c.(292-297)ATGGTG>ATTTTG	p.98_99MV>IL		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	98_99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TAGGGTGCATGGTGCAATTCTA	0.465										HNSCC(27;0.073)			21	129					0	0	0	0	TT	55594989	TT	TT	55594988	3	4	58	1	0	0	0	0	1	0	0	0	11225	1348	47	4	296	4	OR5L2	11	55594988	Missense_Mutation	DNP	GG	TCGA-CN-5360-01A-01D-1434-08	7018	55594988	79411528	350	11735											
OR10AG1	282770	broad.mit.edu	37	chr11	55735898	55735898	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atactaaaaagcatccagtgGagattgggaatatcagaaaa	19	8	9	5	0	1	2	1	0	0	2	2	4	2	3	1	2	2	1	1	2	8	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:55735898G>A	uc010rit.1	-	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GCATCCAGTGGAGATTGGGAA	0.338													4	75					0	0	0	0	A	55735898	A	A	55735898	2	1	58	1	0	0	0	0	0	0	0	1	10951	1161	41	2		2	OR10AG1	11	55735898	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	140910	55735898	79270618	351	11736											
OR8K3	219473	broad.mit.edu	37	chr11	56085893	56085893	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctcatgatctatgtgatCtcagtgatgggcaatttggg	8	15	11	7	0	3	3	2	3	2	0	5	3	4	3	1	2	0	1	1	2	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:56085893C>A	uc010rjf.1	+	1	111	c.111C>A	c.(109-111)ATC>ATA	p.I37I		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TCTATGTGATCTCAGTGATGG	0.433													65	119					5.08636e-23	7.69736e-23	1	0	A	56085893	A	A	56085893	2	1	58	1	0	0	0	0	0	0	0	1	11298	903	32	2		2	OR8K3	11	56085893	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	349995	56085893	78920623	352	11737											
OR5M3	219482	broad.mit.edu	37	chr11	56237592	56237592	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattttactgccataaagcaGaggattcccaattgccatgt	12	12	7	10	0	0	1	0	0	0	1	1	2	1	2	3	1	4	1	3	1	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:56237592G>T	uc010rjk.1	-	1	382	c.382C>A	c.(382-384)CTG>ATG	p.L128M		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CCATAAAGCAGAGGATTCCCA	0.393													35	114					6.33695e-27	9.85265e-27	1	0	T	56237592	T	T	56237592	3	4	58	1	0	0	0	0	1	0	0	0	11229	933	33	2	543	2	OR5M3	11	56237592	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	151699	56237592	78768924	353	11738											
OR5M8	219484	broad.mit.edu	37	chr11	56258070	56258070	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattcctttgaggggggtctGagatacatgaagaaaagggt	12	10	15	4	0	1	4	0	3	1	2	2	6	2	4	1	4	1	0	1	4	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:56258070G>A	uc001nix.1	-	1	777	c.777C>T	c.(775-777)CTC>CTT	p.L259L		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					AGGGGGGTCTGAGATACATGA	0.413													34	59					0	0	0	0	A	56258070	A	A	56258070	2	1	58	1	0	0	0	0	0	0	0	1	11230	1277	45	2		2	OR5M8	11	56258070	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	20478	56258070	78748446	354	11739											
OR5AR1	219493	broad.mit.edu	37	chr11	56431893	56431893	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctccacctgcgggtctcaCcttactggcatcaccctctt	5	13	6	17	1	4	0	2	0	3	0	6	0	4	0	4	2	2	1	4	2	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:56431893C>A	uc010rjm.1	+	1	732	c.732C>A	c.(730-732)CAC>CAA	p.H244Q		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCGGGTCTCACCTTACTGGCA	0.498													40	92					1.30091e-30	2.06508e-30	1	0	A	56431893	A	A	56431893	3	1	58	1	0	0	0	0	1	0	0	0	11199	506	18	4	734	4	OR5AR1	11	56431893	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	173823	56431893	78574623	355	11740											
OR9G4	283189	broad.mit.edu	37	chr11	56510975	56510975	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccagccaaggaaatgcgctTatcttctgagacacaactgg	12	9	9	11	1	2	1	0	1	2	1	3	3	3	2	2	2	3	1	2	2	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:56510975T>C	uc010rjo.1	-	1	313	c.313A>G	c.(313-315)AAG>GAG	p.K105E		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	105	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GAAATGCGCTTATCTTCTGAG	0.458													6	125					0	0	0	0	C	56510975	C	C	56510975	3	2	58	1	0	0	0	0	1	0	0	0	11305	1763	61	5	673	5	OR9G4	11	56510975	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	79082	56510975	78495541	356	11741											
OR4D10	390197	broad.mit.edu	37	chr11	59245402	59245402	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccctgttgctcccactccCtttctgcggacccaatgttc	4	14	6	17	1	1	0	0	0	1	0	5	1	4	1	4	1	2	3	4	1	1	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:59245402C>A	uc001nnz.1	+	1	500	c.500C>A	c.(499-501)CCT>CAT	p.P167H		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CTCCCACTCCCTTTCTGCGGA	0.493													7	145					5.18039e-06	5.70849e-06	1	0	A	59245402	A	A	59245402	3	1	58	1	0	0	0	0	1	0	0	0	11108	681	24	4	502	4	OR4D10	11	59245402	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2734427	59245402	75761114	357	11742											
TCN1	6947	broad.mit.edu	37	chr11	59622211	59622211	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtgacattggtgaaataTgtttcattgattctcacaga	13	14	8	6	0	2	4	2	3	1	1	3	4	2	4	0	1	0	1	0	1	2	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:59622211T>C	uc001noj.2	-	7	1133	c.1035A>G	c.(1033-1035)ACA>ACG	p.T345T		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	345					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGGTGAAATATGTTTCATTGA	0.408													9	145					0	0	0	0	C	59622211	C	C	59622211	2	2	58	1	0	0	0	0	0	0	0	1	15772	1451	51	5		5	TCN1	11	59622211	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	376809	59622211	75384305	358	11743											
TPCN2	219931	broad.mit.edu	37	chr11	68830381	68830381	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atccgccggcttctccgtccCttcttcctgctgcagaactc	4	12	7	18	3	2	1	0	0	2	1	7	1	5	1	5	1	3	3	5	1	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:68830381C>A	uc001oos.2	+	6	692	c.576C>A	c.(574-576)CCC>CCA	p.P192P	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Silent_p.P107P|TPCN2_uc010rqg.1_Silent_p.P192P	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	192	Helical; Name=S4 of repeat I; (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTCTCCGTCCCTTCTTCCTGC	0.582													56	162					6.75472e-32	1.0849e-31	1	0	A	68830381	A	A	68830381	2	1	58	1	0	0	0	0	0	0	0	1	16463	668	24	4		4	TPCN2	11	68830381	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	9208170	68830381	66176135	359	11744											
PHOX2A	401	broad.mit.edu	37	chr11	71950813	71950813	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctagaagagattggtcttcaGggcggggccgggcttccggt	6	9	17	9	3	2	2	1	0	1	2	3	3	3	2	2	6	0	1	2	6	2	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:71950813G>T	uc001osh.3	-	3	1007	c.835C>A	c.(835-837)CTG>ATG	p.L279M		NM_005169	NP_005160	O14813	PHX2A_HUMAN	paired-like homeobox 2a	279					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTGGTCTTCAGGGCGGGGCCG	0.692													4	4					0.000602214	0.000635826	1	0	T	71950813	T	T	71950813	3	4	58	1	0	0	0	0	1	0	0	0	11913	991	35	4	23	4	PHOX2A	11	71950813	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3120432	71950813	63055703	360	11745											
C2CD3	26005	broad.mit.edu	37	chr11	73753213	73753213	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attcatgaaaccggcgaatgTtctgcacatgctcttcatgg	10	12	9	10	2	4	1	2	1	2	0	4	2	4	1	1	2	3	3	1	2	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:73753213T>A	uc001ouu.2	-	29	5773	c.5546A>T	c.(5545-5547)AAC>ATC	p.N1849I	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1849						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					CCGGCGAATGTTCTGCACATG	0.433													39	56					0	0	0	0	A	73753213	A	A	73753213	3	1	58	1	0	0	0	0	1	0	0	0	2164	1725	60	5	357	5	C2CD3	11	73753213	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1802400	73753213	61253303	361	11746											
SYTL2	54843	broad.mit.edu	37	chr11	85524734	85524737	+	5'Flank	DEL	CCTC	-	-																															gggtgactttagacaagtctCctccctccctccctccctcc																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:85524734_85524737delCCTC	uc010rti.1	-						SYTL2_uc010rtj.1_5'Flank	NM_032943	NP_116561	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform a						intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		AGACAAGTCtcctccctccctccc	0.064													---	---	---								-	85524737	-	-	85524734	6	5	58	0	1	1	0	1	0	0	0	0	15549	870	30	0		0	SYTL2	11	85524734	5'Flank	DEL	CCTC	TCGA-CN-5360-01A-01D-1434-08	11771521	85524734	49481782	362	11747											
TMEM135	65084	broad.mit.edu	37	chr11	87013387	87013387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cacattctttttcaccagagGcagcatatgcaaaagtggaa	14	10	8	9	0	2	1	1	0	1	1	2	2	2	2	1	2	2	3	1	2	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:87013387G>A	uc001pch.2	+	8	624	c.601G>A	c.(601-603)GCA>ACA	p.A201T	TMEM135_uc010rtt.1_Missense_Mutation_p.A62T|TMEM135_uc001pci.2_Missense_Mutation_p.A179T	NM_022918	NP_075069	Q86UB9	TM135_HUMAN	transmembrane protein 135	201						integral to membrane					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTCACCAGAGGCAGCATATGC	0.378													25	57					0	0	0	0	A	87013387	A	A	87013387	3	1	58	1	0	0	0	0	1	0	0	0	16117	1203	42	4	631	4	TMEM135	11	87013387	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1488653	87013387	47993129	363	11748											
CNTN5	53942	broad.mit.edu	37	chr11	99827584	99827584	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagttcccttcctttgtggcGgaagacagccggcggttcat	6	11	13	11	3	1	1	1	0	0	1	3	3	3	2	3	4	1	2	3	4	1	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:99827584G>T	uc001pga.2	+	8	1059	c.720G>T	c.(718-720)GCG>GCT	p.A240A	CNTN5_uc009ywv.1_Silent_p.A240A|CNTN5_uc001pfz.2_Silent_p.A240A|CNTN5_uc001pgb.2_Silent_p.A166A	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	240	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCTTTGTGGCGGAAGACAGCC	0.393													17	50					4.96729e-08	5.74317e-08	1	0	T	99827584	T	T	99827584	2	4	58	1	0	0	0	0	0	0	0	1	3659	1103	39	3		3	CNTN5	11	99827584	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	12814197	99827584	35178932	364	11749											
MMP10	4319	broad.mit.edu	37	chr11	102646043	102646043	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggttccagtgggatcttcgCcaaaaatatctgtaatacat	12	12	9	8	1	2	0	0	0	2	0	4	1	3	1	2	2	1	2	2	2	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:102646043C>T	uc001phg.1	-	7	964	c.942G>A	c.(940-942)TGG>TGA	p.W314*		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	314	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		GGGATCTTCGCCAAAAATATC	0.328													4	57					0	0	0	0	T	102646043	T	T	102646043	4	4	58	1	0	0	0	0	0	1	0	0	9702	740	26	4	504	4	MMP10	11	102646043	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2818459	102646043	32360473	365	11750											
CASP5	838	broad.mit.edu	37	chr11	104869720	104869720	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagatgagtgccaaggatgCtggagagtctctgacccaga	12	7	14	8	0	1	5	0	2	1	3	2	8	1	6	2	2	2	1	2	2	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:104869720C>T	uc010rva.1	-	7	1020	c.988G>A	c.(988-990)GCA>ACA	p.A330T	CASP5_uc010ruz.1_Missense_Mutation_p.A343T|CASP5_uc010rvb.1_Missense_Mutation_p.A272T|CASP5_uc010rvc.1_Missense_Mutation_p.A188T|CASP5_uc009yxh.2_Missense_Mutation_p.A112T|CASP5_uc010rvd.1_Missense_Mutation_p.A112T	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	330					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		GCCAAGGATGCTGGAGAGTCT	0.358													26	59					0	0	0	0	T	104869720	T	T	104869720	3	4	58	1	0	0	0	0	1	0	0	0	2686	797	28	4	328	4	CASP5	11	104869720	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2223677	104869720	30136796	366	11751											
AASDHPPT	60496	broad.mit.edu	37	chr11	105967590	105967590	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcattttgggactgttttTgcttcacagaagaaattcca	10	16	7	8	0	2	2	2	0	0	2	3	3	3	3	1	1	1	2	1	1	2	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:105967590T>C	uc001pjc.1	+	6	1032	c.886T>C	c.(886-888)TGC>CGC	p.C296R	AASDHPPT_uc010rvn.1_RNA|AASDHPPT_uc001pjd.1_Missense_Mutation_p.C149R	NM_015423	NP_056238	Q9NRN7	ADPPT_HUMAN	aminoadipate-semialdehyde	296					macromolecule biosynthetic process|pantothenate metabolic process	cytosol	holo-[acyl-carrier-protein] synthase activity|magnesium ion binding|protein binding				0		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.78e-05)|Epithelial(105;0.00622)|all cancers(92;0.041)		GGACTGTTTTTGCTTCACAGA	0.378													11	48					0	0	0	0	C	105967590	C	C	105967590	3	2	58	1	0	0	0	0	1	0	0	0	23	1812	63	5	908	5	AASDHPPT	11	105967590	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1097870	105967590	29038926	367	11752											
OR10G8	219869	broad.mit.edu	37	chr11	123900787	123900787	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttggctcagtggctctcTgcactctgctgtccaggcca	5	11	10	15	0	3	0	1	0	2	0	5	0	4	0	2	3	2	4	2	3	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:123900787T>A	uc001pzp.1	+	1	458	c.458T>A	c.(457-459)CTG>CAG	p.L153Q		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGTGGCTCTCTGCACTCTGCT	0.552													51	115					0	0	0	0	A	123900787	A	A	123900787	3	1	58	1	0	0	0	0	1	0	0	0	10957	1580	55	5	460	5	OR10G8	11	123900787	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	17933197	123900787	11105729	368	11753											
VSIG2	23584	broad.mit.edu	37	chr11	124617497	124617497	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcagacgagggtctttccagGaaccccttgctagaatcagc	10	8	11	12	1	2	2	1	0	1	2	3	4	3	3	3	2	3	2	3	2	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:124617497G>A	uc001qas.2	-	7	994	c.918C>T	c.(916-918)TTC>TTT	p.F306F		NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	306	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		GTCTTTCCAGGAACCCCTTGC	0.562													6	66					0	0	0	0	A	124617497	A	A	124617497	2	1	58	1	0	0	0	0	0	0	0	1	17292	1165	41	2		2	VSIG2	11	124617497	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	716710	124617497	10389019	369	11754											
ROBO4	54538	broad.mit.edu	37	chr11	124761626	124761626	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgactgctgaggctgctgctGctgctcaggtcccgagagcc	5	8	14	14	2	1	2	1	1	0	1	2	4	2	2	2	2	6	6	2	2	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:124761626G>C	uc001qbg.2	-	11	1760	c.1620C>G	c.(1618-1620)AGC>AGG	p.S540R	ROBO4_uc010sas.1_Missense_Mutation_p.S395R|ROBO4_uc001qbh.2_Missense_Mutation_p.S430R|ROBO4_uc001qbi.2_Missense_Mutation_p.S98R|ROBO4_uc010sat.1_Missense_Mutation_p.S98R	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	540					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GGCTGCTGCTGCTGCTCAGGT	0.662													12	20					0	0	0	0	C	124761626	C	C	124761626	3	2	58	1	0	0	0	0	1	0	0	0	13581	1310	46	4	1435	4	ROBO4	11	124761626	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	144129	124761626	10244890	370	11755											
FGF23	8074	broad.mit.edu	37	chr12	4479648	4479648	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctcgggagctcctgtgaaCaggaggccggggccggggtc	5	5	19	12	4	0	1	0	1	0	0	3	3	1	3	3	7	2	2	3	7	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:4479648C>A	uc001qmq.1	-	3	763	c.617G>T	c.(616-618)TGT>TTT	p.C206F		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	206					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CTCCTGTGAACAGGAGGCCGG	0.706													14	33					0.000308642	0.000327902	1	0	A	4479648	A	A	4479648	3	1	58	1	0	0	0	0	1	0	0	0	5884	478	17	4	142	4	FGF23	12	4479648	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08		4479648	129372247	371	11756											
NTF3	4908	broad.mit.edu	37	chr12	5603242	5603242	+	5'Flank	DEL	G	-	-																															gggagttgccttgcttacctGgggggcggtaccctctctcg																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:5603242delG	uc001qnl.3	+						NTF3_uc001qnk.3_Intron	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein						signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						TTGCTTACCTGGGGGGCGGTA	0.582													---	---	---								-	5603242	-	-	5603242	6	5	58	0	1	1	0	1	0	0	0	0	10750	1363	47	0		0	NTF3	12	5603242	5'Flank	DEL	G	TCGA-CN-5360-01A-01D-1434-08	1123594	5603242	128248653	372	11757											
TAS2R50	259296	broad.mit.edu	37	chr12	11139067	11139067	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaaagtccccaacagtatCaccagaatgacactcctaac	16	7	4	14	0	2	2	2	1	0	1	4	2	4	2	4	0	2	1	4	0	5	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:11139067C>T	uc001qzl.2	-	1	445	c.393G>A	c.(391-393)GTG>GTA	p.V131V	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	131	Helical; Name=4; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						CCAACAGTATCACCAGAATGA	0.388													80	256					0	0	0	0	T	11139067	T	T	11139067	2	4	58	1	0	0	0	0	0	0	0	1	15650	813	29	2		2	TAS2R50	12	11139067	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5535825	11139067	122712828	373	11758											
GRIN2B	2904	broad.mit.edu	37	chr12	13717318	13717318	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaggttctcctcacagggcgGgttgttgtaggatttgcagt	6	13	15	7	1	2	0	1	0	1	0	3	2	2	1	1	4	1	5	1	4	1	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:13717318G>T	uc001rbt.2	-	13	3033	c.2854C>A	c.(2854-2856)CCG>ACG	p.P952T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	952	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCACAGGGCGGGTTGTTGTAG	0.542													40	94					8.16904e-11	1.03212e-10	1	0	T	13717318	T	T	13717318	3	4	58	1	0	0	0	0	1	0	0	0	6819	1232	43	4	1604	4	GRIN2B	12	13717318	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2578251	13717318	120134577	374	11759											
PTPRO	5800	broad.mit.edu	37	chr12	15475702	15475702	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atacacggcgcccgccgcctCctgcctctgctctggctctt	3	10	9	19	4	3	0	0	0	3	0	4	0	4	0	5	2	3	2	5	2	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:15475702C>A	uc001rcv.1	+	1	216	c.42C>A	c.(40-42)CTC>CTA	p.L14L	PTPRO_uc001rcw.1_Silent_p.L14L|PTPRO_uc001rcu.1_Silent_p.L14L	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	14						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				CCCGCCGCCTCCTGCCTCTGC	0.741													10	21					1.15088e-07	1.31501e-07	1	0	A	15475702	A	A	15475702	2	1	58	1	0	0	0	0	0	0	0	1	12874	842	30	2		2	PTPRO	12	15475702	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1758384	15475702	118376193	375	11760											
GYS2	2998	broad.mit.edu	37	chr12	21721901	21721901	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctcgctccatgcagtaccGgtggtaaatctgcctttccc	7	11	9	14	2	1	0	0	0	1	0	4	0	3	0	4	2	4	5	4	2	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:21721901G>C	uc001rfb.2	-	5	976	c.721C>G	c.(721-723)CGG>GGG	p.R241G		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	241					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						ATGCAGTACCGGTGGTAAATC	0.433													24	112					0	0	0	0	C	21721901	C	C	21721901	3	2	58	1	0	0	0	0	1	0	0	0	6952	1115	39	3	1438	3	GYS2	12	21721901	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6246199	21721901	112129994	376	11761											
ABCC9	10060	broad.mit.edu	37	chr12	22013989	22013989	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcatctgtgacagctttgtaCctttgggagaaatgattttg	9	15	11	6	0	1	3	0	2	1	1	1	4	1	3	1	1	2	3	1	1	2	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:22013989C>T	uc001rfi.1	-	19	2360	c.2340G>A	c.(2338-2340)AGG>AGA	p.R780R	ABCC9_uc001rfh.2_Silent_p.R780R|ABCC9_uc001rfj.1_Silent_p.R744R	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	780	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGCTTTGTACCTTTGGGAGA	0.323													23	99					0	0	0	0	T	22013989	T	T	22013989	2	4	58	1	0	0	0	0	0	0	0	1	59	521	18	4		4	ABCC9	12	22013989	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	292088	22013989	111837906	377	11762											
KIAA0528	9847	broad.mit.edu	37	chr12	22676469	22676469	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcaccactaacccagactCgccctccagatcgaaacact	12	6	5	18	3	0	2	0	0	0	2	4	3	1	2	4	0	2	1	4	0	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:22676469C>A	uc001rfq.2	-	7	919	c.691G>T	c.(691-693)GAG>TAG	p.E231*	KIAA0528_uc010sir.1_Nonsense_Mutation_p.E33*|KIAA0528_uc010sis.1_Nonsense_Mutation_p.E231*|KIAA0528_uc010sit.1_Nonsense_Mutation_p.E231*|KIAA0528_uc010siu.1_Nonsense_Mutation_p.E231*|KIAA0528_uc001rfr.2_Nonsense_Mutation_p.E231*|KIAA0528_uc009ziy.1_Nonsense_Mutation_p.E231*	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	231							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						AACCCAGACTCGCCCTCCAGA	0.473													16	49					2.31682e-05	2.50437e-05	1	0	A	22676469	A	A	22676469	4	1	58	1	0	0	0	0	0	1	0	0	8221	893	31	3	2387	3	KIAA0528	12	22676469	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	662480	22676469	111175426	378	11763											
BICD1	636	broad.mit.edu	37	chr12	32480467	32480467	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agctggaacacaccaaggggGcactgacggagcagcatgag	13	3	15	10	1	0	2	0	2	0	0	0	4	0	4	1	4	4	4	1	4	2	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:32480467G>T	uc001rku.2	+	5	1159	c.1078G>T	c.(1078-1080)GCA>TCA	p.A360S	BICD1_uc001rkv.2_Missense_Mutation_p.A360S|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	360	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CACCAAGGGGGCACTGACGGA	0.562													28	58					1.16021e-09	1.42105e-09	1	0	T	32480467	T	T	32480467	3	4	58	1	0	0	0	0	1	0	0	0	1431	1203	42	4	1096	4	BICD1	12	32480467	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	9803998	32480467	101371428	379	11764											
MFSD5	84975	broad.mit.edu	37	chr12	53647566	53647566	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcagcccatgcacctgctgtCccttgctgtgctcatcgtcg	4	12	9	16	2	2	0	2	0	0	0	5	0	3	0	3	0	5	4	3	0	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:53647566C>T	uc001sci.1	+	2	1138	c.947C>T	c.(946-948)TCC>TTC	p.S316F	MFSD5_uc001sch.1_Missense_Mutation_p.S423F	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	316	Helical; (Potential).				transport	integral to membrane				skin(2)|ovary(1)	3						CACCTGCTGTCCCTTGCTGTG	0.542													42	105					0	0	0	0	T	53647566	T	T	53647566	3	4	58	1	0	0	0	0	1	0	0	0	9587	855	30	2	1274	2	MFSD5	12	53647566	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	21167099	53647566	80204329	380	11765											
OR9K2	441639	broad.mit.edu	37	chr12	55523823	55523823	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtattttttcctaggcaatCtctccttcattgatcttttc	6	21	4	10	0	3	1	1	1	2	0	7	1	5	1	2	1	0	2	2	1	3	9			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:55523823C>A	uc010spe.1	+	1	271	c.271C>A	c.(271-273)CTC>ATC	p.L91I		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	91	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						CCTAGGCAATCTCTCCTTCAT	0.408													68	278					2.69673e-31	4.31098e-31	1	0	A	55523823	A	A	55523823	3	1	58	1	0	0	0	0	1	0	0	0	11308	913	32	2	273	2	OR9K2	12	55523823	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1876257	55523823	78328072	381	11766											
OR6C76	390326	broad.mit.edu	37	chr12	55820376	55820376	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acggagtttttcctcctggcCtctatgtcctatgattgcta	6	16	8	11	1	1	1	0	1	1	0	4	2	4	2	4	2	1	2	4	2	3	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:55820376C>T	uc010spm.1	+	1	339	c.339C>T	c.(337-339)GCC>GCT	p.A113A		NM_001005183	NP_001005183	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCTCCTGGCCTCTATGTCCT	0.413													86	263					0	0	0	0	T	55820376	T	T	55820376	2	4	58	1	0	0	0	0	0	0	0	1	11254	668	24	4		4	OR6C76	12	55820376	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	296553	55820376	78031519	382	11767											
LRP1	4035	broad.mit.edu	37	chr12	57572180	57572180	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcccgttacgacggctctgGccacatggaggtgcttcggg	6	8	15	12	4	1	0	0	0	1	0	2	2	1	1	2	5	3	3	2	5	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:57572180G>A	uc001snd.2	+	27	4866	c.4400G>A	c.(4399-4401)GGC>GAC	p.G1467D		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1467	Extracellular (Potential).|LDL-receptor class B 11.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GACGGCTCTGGCCACATGGAG	0.582													16	54					0	0	0	0	A	57572180	A	A	57572180	3	1	58	1	0	0	0	0	1	0	0	0	9001	1203	42	4	4506	4	LRP1	12	57572180	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1751804	57572180	76279715	383	11768											
AGAP2	116986	broad.mit.edu	37	chr12	58125675	58125676	+	Silent	DNP	GG	TT	TT																															cactgcagctgcctcggctcGgagctcccggtgaccaacat																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:58125675_58125676GG>TT	uc001spq.2	-	8	1869_1870	c.1869_1870CC>AA	c.(1867-1872)CTCCGA>CTAAGA	p.623_624LR>LR	AGAP2_uc001spp.2_Silent_p.623_624LR>LR|AGAP2_uc001spr.2_Silent_p.287_288LR>LR	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	623_624					axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						GCCTCGGCTCGGAGCTCCCGGT	0.609													4	14					0	0	0	0	TT	58125676	TT	TT	58125675	2	4	58	1	0	0	0	0	0	0	0	1	368	1124	39	3		3	AGAP2	12	58125675	Silent	DNP	GG	TCGA-CN-5360-01A-01D-1434-08	553495	58125675	75726220	384	11769											
BEST3	144453	broad.mit.edu	37	chr12	70049538	70049538	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcatggaatgccgatggcCatgcttctcataatcccaca	11	11	7	12	1	2	0	2	0	1	0	4	2	3	1	3	2	2	1	3	2	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:70049538C>A	uc001svg.2	-	10	1383	c.1156G>T	c.(1156-1158)GGC>TGC	p.G386C	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.G173C|BEST3_uc010stm.1_Missense_Mutation_p.G280C	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	386	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TGCCGATGGCCATGCTTCTCA	0.547													35	117					2.75727e-19	3.96977e-19	1	0	A	70049538	A	A	70049538	3	1	58	1	0	0	0	0	1	0	0	0	1408	594	21	4	854	4	BEST3	12	70049538	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	11923863	70049538	63802357	385	11770											
TRHDE	29953	broad.mit.edu	37	chr12	72866900	72866900	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaagacgtgtggctgaaggaAgggtttgctcactactttga	10	11	14	6	1	1	3	1	2	0	1	1	5	1	4	0	3	2	3	0	3	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:72866900A>T	uc001sxa.2	+	5	1419	c.1389A>T	c.(1387-1389)GAA>GAT	p.E463D		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	463	Extracellular (Potential).	Zinc; catalytic (By similarity).			cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GGCTGAAGGAAGGGTTTGCTC	0.408													41	151					0	0	0	0	T	72866900	T	T	72866900	3	4	58	1	0	0	0	0	1	0	0	0	16546	69	3	5	1407	5	TRHDE	12	72866900	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	2817362	72866900	60984995	386	11771											
TRHDE	29953	broad.mit.edu	37	chr12	72956721	72956721	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatcctgttatcaccatctTgggaaacacaacagcagaaa	15	10	6	10	0	2	1	1	0	1	1	3	2	3	2	2	1	3	2	2	1	5	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:72956721T>C	uc001sxa.2	+	9	1838	c.1808T>C	c.(1807-1809)TTG>TCG	p.L603S		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	603	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						ATCACCATCTTGGGAAACACA	0.338													60	168					0	0	0	0	C	72956721	C	C	72956721	3	2	58	1	0	0	0	0	1	0	0	0	16546	1821	63	5	1842	5	TRHDE	12	72956721	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	89821	72956721	60895174	387	11772											
NAV3	89795	broad.mit.edu	37	chr12	78444555	78444555	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgacagcaccctggagaCaacatttgacagcactgtga	13	9	9	10	0	0	4	0	3	0	1	0	5	0	4	1	1	3	2	1	1	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:78444555C>A	uc001syp.2	+	11	2317	c.2144C>A	c.(2143-2145)ACA>AAA	p.T715K	NAV3_uc001syo.2_Missense_Mutation_p.T715K|NAV3_uc010sub.1_Missense_Mutation_p.T215K	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	715						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACCCTGGAGACAACATTTGAC	0.463										HNSCC(70;0.22)			23	96					4.7796e-09	5.70037e-09	1	0	A	78444555	A	A	78444555	3	1	58	1	0	0	0	0	1	0	0	0	10238	478	17	4	2186	4	NAV3	12	78444555	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5487834	78444555	55407340	388	11773											
NAV3	89795	broad.mit.edu	37	chr12	78444857	78444857	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tggacatgtcttctgaggtcGatgtgggtggatatatgagt	8	14	15	4	1	2	2	0	2	2	0	3	5	2	4	0	4	0	0	0	4	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:78444857G>C	uc001syp.2	+	11	2619	c.2446G>C	c.(2446-2448)GAT>CAT	p.D816H	NAV3_uc001syo.2_Missense_Mutation_p.D816H|NAV3_uc010sub.1_Missense_Mutation_p.D316H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	816						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TTCTGAGGTCGATGTGGGTGG	0.493										HNSCC(70;0.22)			12	56					0	0	0	0	C	78444857	C	C	78444857	3	2	58	1	0	0	0	0	1	0	0	0	10238	1058	37	3	2488	3	NAV3	12	78444857	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	302	78444857	55407038	389	11774											
NAV3	89795	broad.mit.edu	37	chr12	78511909	78511909	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgacagccatggggatgctGgtggcaagtggaagactgtg	9	9	17	6	0	0	2	0	1	0	1	0	4	0	4	1	5	2	2	1	5	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:78511909G>T	uc001syp.2	+	14	3045	c.2872G>T	c.(2872-2874)GGT>TGT	p.G958C	NAV3_uc001syo.2_Missense_Mutation_p.G958C|NAV3_uc010sub.1_Missense_Mutation_p.G458C|NAV3_uc009zsf.2_5'UTR	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	958						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TGGGGATGCTGGTGGCAAGTG	0.522										HNSCC(70;0.22)			35	138					2.40579e-17	3.3504e-17	1	0	T	78511909	T	T	78511909	3	4	58	1	0	0	0	0	1	0	0	0	10238	1348	47	4	2926	4	NAV3	12	78511909	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	67052	78511909	55339986	390	11775											
NAV3	89795	broad.mit.edu	37	chr12	78562633	78562633	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggagcactgaatggtccagaCcatcctcccaaaggtatatt	12	9	9	11	0	0	2	0	1	0	1	3	3	3	3	4	3	1	2	4	3	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:78562633C>A	uc001syp.2	+	24	5141	c.4968C>A	c.(4966-4968)GAC>GAA	p.D1656E	NAV3_uc001syo.2_Missense_Mutation_p.D1656E|NAV3_uc010sub.1_Missense_Mutation_p.D1142E|NAV3_uc009zsf.2_Missense_Mutation_p.D487E	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1656						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ATGGTCCAGACCATCCTCCCA	0.378										HNSCC(70;0.22)			27	109					6.32553e-13	8.28401e-13	1	0	A	78562633	A	A	78562633	3	1	58	1	0	0	0	0	1	0	0	0	10238	506	18	4	5062	4	NAV3	12	78562633	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	50724	78562633	55289262	391	11776											
GAS2L3	283431	broad.mit.edu	37	chr12	101012273	101012273	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaaacttgagaaagaaattGagttagaagagactttgctt	17	12	9	3	0	0	5	0	2	0	4	0	7	0	5	0	0	2	2	0	0	6	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:101012273G>C	uc001thu.2	+	8	782	c.556G>C	c.(556-558)GAG>CAG	p.E186Q	GAS2L3_uc009zty.2_Missense_Mutation_p.E186Q|GAS2L3_uc001thv.2_Missense_Mutation_p.E82Q	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	186					cell cycle arrest					skin(1)	1						GAAAGAAATTGAGTTAGAAGA	0.423													26	74					0	0	0	0	C	101012273	C	C	101012273	3	2	58	1	0	0	0	0	1	0	0	0	6283	1291	45	2	578	2	GAS2L3	12	101012273	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	22449640	101012273	32839622	392	11777											
STAB2	55576	broad.mit.edu	37	chr12	104044339	104044339	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgctgttacctacagacaagGgactgaaaggattcaatgtg	13	10	11	7	0	1	2	1	1	0	1	1	4	1	4	1	2	3	2	1	2	5	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:104044339G>T	uc001tjw.2	+	11	1426	c.1240G>T	c.(1240-1242)GGA>TGA	p.G414*		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	414	Extracellular (Potential).|FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TACAGACAAGGGACTGAAAGG	0.423													9	31					2.74318e-10	3.41518e-10	1	0	T	104044339	T	T	104044339	4	4	58	1	0	0	0	0	0	1	0	0	15304	1233	43	4	1282	4	STAB2	12	104044339	Nonsense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3032066	104044339	29807556	393	11778											
STAB2	55576	broad.mit.edu	37	chr12	104106206	104106206	+	Frame_Shift_Del	DEL	G	-	-																															cagcaggattccaaggaaacGggaccatctgcacaggcaag																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:104106206delG	uc001tjw.2	+	41	4582	c.4396delG	c.(4396-4398)GGGfs	p.G1466fs	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1466	Extracellular (Potential).|EGF-like 11.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCAAGGAAACGGGACCATCTG	0.512													---	---	---								-	104106206	-	-	104106206	7	5	58	1	0	1	0	1	0	0	0	0	15304	1116	39	0	4558	0	STAB2	12	104106206	Frame_Shift_Del	DEL	G	TCGA-CN-5360-01A-01D-1434-08	61867	104106206	29745689	394	11779											
POLR3B	55703	broad.mit.edu	37	chr12	106786921	106786921	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaaagctcagattttcaCacagatgcaggtgtgtcttt	11	12	9	9	0	3	3	2	0	1	3	3	3	3	3	1	1	2	2	1	1	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:106786921C>T	uc001tlp.2	+	10	1058	c.836C>T	c.(835-837)ACA>ATA	p.T279I	POLR3B_uc001tlq.2_Missense_Mutation_p.T221I	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	279					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						CAGATTTTCACACAGATGCAG	0.458													73	188					0	0	0	0	T	106786921	T	T	106786921	3	4	58	1	0	0	0	0	1	0	0	0	12284	478	17	4	874	4	POLR3B	12	106786921	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2680715	106786921	27064974	395	11780											
NAA25	80018	broad.mit.edu	37	chr12	112491432	112491432	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acgcagcagcatactgacctAgagattcagcatatcgggtc	12	8	10	11	2	1	2	1	1	0	1	3	3	1	2	1	1	4	4	1	1	3	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:112491432A>G	uc001ttm.2	-	15	1678	c.1658T>C	c.(1657-1659)CTA>CCA	p.L553P	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.L525P|NAA25_uc009zwa.1_Missense_Mutation_p.L553P	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	553						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						ATACTGACCTAGAGATTCAGC	0.358													9	32					0	0	0	0	G	112491432	G	G	112491432	3	3	58	1	0	0	0	0	1	0	0	0	10174	420	15	5	1300	5	NAA25	12	112491432	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	5704511	112491432	21360463	396	11781											
TBX5	6910	broad.mit.edu	37	chr12	114793739	114793739	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgggcacaggctcgctgggGggcgcagagctggcatacat	7	6	17	11	2	0	1	0	0	0	1	1	1	0	1	0	6	2	6	0	6	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:114793739G>T	uc001tvo.2	-	9	1650	c.1155C>A	c.(1153-1155)CCC>CCA	p.P385P	TBX5_uc001tvp.2_Silent_p.P385P|TBX5_uc001tvq.2_Silent_p.P335P	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	385					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GCTCGCTGGGGGGCGCAGAGC	0.632													10	86					7.48243e-07	8.40847e-07	1	0	T	114793739	T	T	114793739	2	4	58	1	0	0	0	0	0	0	0	1	15727	1219	43	4		4	TBX5	12	114793739	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2302307	114793739	19058156	397	11782											
DHX37	57647	broad.mit.edu	37	chr12	125470763	125470763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttctttttcttcttccccGgtagaacgagcgcgttgctt	4	17	8	12	4	4	1	0	0	4	1	5	2	5	1	2	1	3	3	2	1	2	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:125470763G>A	uc001ugy.2	-	2	254	c.155C>T	c.(154-156)CCG>CTG	p.P52L		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	52							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CTTCTTCCCCGGTAGAACGAG	0.493													50	129					0	0	0	0	A	125470763	A	A	125470763	3	1	58	1	0	0	0	0	1	0	0	0	4532	1116	39	1	3422	1	DHX37	12	125470763	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	10677024	125470763	8381132	398	11783											
GPR133	283383	broad.mit.edu	37	chr12	131620641	131620641	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggtacctcgtgggtctttgGcgtgcttgctgtcaacggtt	3	14	15	9	3	2	0	1	0	1	0	3	0	2	0	1	4	4	4	1	4	2	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:131620641G>A	uc001uit.3	+	22	2886	c.2327G>A	c.(2326-2328)GGC>GAC	p.G776D	GPR133_uc010tbm.1_Missense_Mutation_p.G808D|GPR133_uc009zyo.2_Missense_Mutation_p.G58D|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	776	Helical; Name=6; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGGGTCTTTGGCGTGCTTGCT	0.617													10	48					0	0	0	0	A	131620641	A	A	131620641	3	1	58	1	0	0	0	0	1	0	0	0	6681	1203	42	4	2413	4	GPR133	12	131620641	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6149878	131620641	2231254	399	11784											
GPR133	283383	broad.mit.edu	37	chr12	131621519	131621519	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcttccctttcttcccaggGactgttcatattcctctttc	4	19	4	14	0	4	0	1	0	3	0	8	1	7	1	3	1	0	1	3	1	1	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:131621519G>T	uc001uit.3	+	23	2955	c.2396G>T	c.(2395-2397)GGA>GTA	p.G799V	GPR133_uc010tbm.1_Missense_Mutation_p.G831V|GPR133_uc009zyo.2_Missense_Mutation_p.G81V|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	799	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TCTTCCCAGGGACTGTTCATA	0.532													19	85					1.85244e-09	2.2527e-09	1	0	T	131621519	T	T	131621519	3	4	58	1	0	0	0	0	1	0	0	0	6681	1188	41	2	2486	2	GPR133	12	131621519	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	878	131621519	2230376	400	11785											
POLE	5426	broad.mit.edu	37	chr12	133241050	133241050	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggagtaccagcgagcccTgagaggacaccacaaactgg	13	4	12	12	1	0	1	0	1	0	1	0	5	0	3	3	3	4	1	3	3	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:133241050T>A	uc001uks.1	-	22	2513	c.2469_splice	c.e22-1	p.G823_splice	POLE_uc010tbq.1_Splice_Site|POLE_uc009zyu.1_Splice_Site_p.G796_splice	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon						base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CAGCGAGCCCTGAGAGGACAC	0.602								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					16	37					0	0	0	0	A	133241050	A	A	133241050	5	1	58	1	0	0	0	0	0	0	1	0	12251	1594	55	5	4505	5	POLE	12	133241050	Splice_Site	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1619531	133241050	610845	401	11786											
RB1	5925	broad.mit.edu	37	chr13	49033970	49033970	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagacaggcatttggaccaaGtaagaaaatcaagcacttca	17	7	9	8	0	2	2	2	0	0	2	2	4	2	3	1	2	1	3	1	2	5	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr13:49033970G>T	uc001vcb.2	+	20	2272	c.2106_splice	c.e20+1	p.Q702_splice		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTTGGACCAAGTAAGAAAATC	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			9	27					7.48243e-07	8.40847e-07	1	0	T	49033970	T	T	49033970	5	4	58	1	0	0	0	0	0	0	1	0	13163	1043	36	4	2185	4	RB1	13	49033970	Splice_Site	SNP	G	TCGA-CN-5360-01A-01D-1434-08		49033970	66135908	402	11787											
MYCBP2	23077	broad.mit.edu	37	chr13	77633756	77633756	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttctgagctactcgtggtggGtttgcctaggttcaagcaga	7	13	13	8	1	2	2	1	1	1	1	3	2	2	2	1	3	4	4	1	3	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr13:77633756G>C	uc001vkf.2	-	78	13019	c.12928C>G	c.(12928-12930)CCC>GCC	p.P4310A	MYCBP2_uc010aev.2_Missense_Mutation_p.P3714A|MYCBP2_uc001vke.2_Missense_Mutation_p.P927A	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTCGTGGTGGGTTTGCCTAGG	0.393													27	69					0	0	0	0	C	77633756	C	C	77633756	3	2	58	1	0	0	0	0	1	0	0	0	10071	1261	44	4	1022	4	MYCBP2	13	77633756	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	28599786	77633756	37536122	403	11788											
GPC5	2262	broad.mit.edu	37	chr13	92345593	92345593	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtgcggatgttaatcctGaagaatttgtaaacagattt	12	15	10	4	1	0	3	0	1	0	2	1	4	1	4	1	2	2	2	1	2	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr13:92345593G>A	uc010tif.1	+	3	844	c.478G>A	c.(478-480)GAA>AAA	p.E160K		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	160						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TGTTAATCCTGAAGAATTTGT	0.448													45	99					0	0	0	0	A	92345593	A	A	92345593	3	1	58	1	0	0	0	0	1	0	0	0	6639	1291	45	2	488	2	GPC5	13	92345593	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	14711837	92345593	22824285	404	11789											
MYO16	23026	broad.mit.edu	37	chr13	109472729	109472729	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgcatcaggcaaacccacaCctcgtgaactgtaatgagga	14	7	9	11	1	1	2	1	2	0	0	2	3	1	3	2	2	3	3	2	2	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr13:109472729C>A	uc001vqt.1	+	8	972	c.846C>A	c.(844-846)CAC>CAA	p.H282Q	MYO16_uc010agk.1_Missense_Mutation_p.H304Q|MYO16_uc001vqu.1_Missense_Mutation_p.H82Q	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	282	ANK 7.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CAAACCCACACCTCGTGAACT	0.438													4	18					0.000602214	0.000635826	1	0	A	109472729	A	A	109472729	3	1	58	1	0	0	0	0	1	0	0	0	10117	506	18	4	872	4	MYO16	13	109472729	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	17127136	109472729	5697149	405	11790											
OR4K14	122740	broad.mit.edu	37	chr14	20482615	20482616	+	Frame_Shift_Ins	INS	-	A	A																															caaagaacagcgtcactaccINSatgatatgtgcagagcaagt																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:20482615_20482616insA	uc010tky.1	-	1	737_738	c.737_738insT	c.(736-738)ATGfs	p.M246fs		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GCGTCACTACCATGATATGTGC	0.49													---	---	---								A	20482616	A	A	20482615	7	5	58	1	0	1	1	0	0	0	0	0	11123	594	21	0	197	0	OR4K14	14	20482615	Frame_Shift_Ins	INS	-	TCGA-CN-5360-01A-01D-1434-08		20482615	86866925	406	11791											
OR5AU1	390445	broad.mit.edu	37	chr14	21623117	21623117	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cattccattgttttcctaccCcaaacctttattaaagcttt	10	17	2	12	0	0	0	0	0	0	0	2	0	2	0	5	0	3	2	5	0	5	9			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:21623117C>A	uc010tlp.1	-	1	1068	c.1068G>T	c.(1066-1068)TGG>TGT	p.W356C		NM_001004731	NP_001004731	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU,	356	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		TTTTCCTACCCCAAACCTTTA	0.428													15	95					4.7546e-09	5.6805e-09	1	0	A	21623117	A	A	21623117	3	1	58	1	0	0	0	0	1	0	0	0	11201	624	22	4	23	4	OR5AU1	14	21623117	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1140502	21623117	85726423	407	11792											
CHD8	57680	broad.mit.edu	37	chr14	21859702	21859702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcccggcgaggggcatcctCacccaccagcaaagtaccat	11	4	10	16	2	1	0	1	0	0	0	2	1	2	0	5	3	3	3	5	3	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:21859702C>T	uc001was.1	-	36	6242	c.6148G>A	c.(6148-6150)GAG>AAG	p.E2050K	CHD8_uc001war.1_Missense_Mutation_p.E1946K	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2329					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GGGGCATCCTCACCCACCAGC	0.557													13	35					0	0	0	0	T	21859702	T	T	21859702	3	4	58	1	0	0	0	0	1	0	0	0	3346	835	29	2	772	2	CHD8	14	21859702	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	236585	21859702	85489838	408	11793											
PNN	5411	broad.mit.edu	37	chr14	39644596	39644596	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgggatccgaatgacgtgaGgtaagggcctaacgggaact	11	6	16	8	4	0	2	0	2	0	0	1	5	1	4	2	4	2	1	2	4	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:39644596G>T	uc001wuw.3	+	1	210	c.113G>T	c.(112-114)AGG>ATG	p.R38M		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	38	Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.|Necessary for interactions with KRT8, KRT18 and KRT19.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		AATGACGTGAGGTAAGGGCCT	0.582													6	19					3.59834e-05	3.87732e-05	1	0	T	39644596	T	T	39644596	3	4	58	1	0	0	0	0	1	0	0	0	12215	1014	35	4	115	4	PNN	14	39644596	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	17784894	39644596	67704944	409	11794											
LRFN5	145581	broad.mit.edu	37	chr14	42356187	42356187	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattacaaatgatatgttcaGtggtctttccaatcttcatc	12	16	5	8	0	4	1	2	1	2	0	6	1	5	1	1	1	1	1	1	1	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:42356187G>A	uc001wvm.2	+	3	1557	c.359G>A	c.(358-360)AGT>AAT	p.S120N	LRFN5_uc010ana.2_Missense_Mutation_p.S120N	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	120	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GATATGTTCAGTGGTCTTTCC	0.373										HNSCC(30;0.082)			27	106					0	0	0	0	A	42356187	A	A	42356187	3	1	58	1	0	0	0	0	1	0	0	0	8991	1029	36	4	361	4	LRFN5	14	42356187	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2711591	42356187	64993353	410	11795											
GNG2	54331	broad.mit.edu	37	chr14	52433376	52433376	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttcagaaaacccgtttaggGagaagaagtttttctgtgcc	11	12	10	8	1	2	3	1	0	1	3	2	4	2	3	2	1	2	2	2	1	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:52433376G>T	uc001wzi.2	+	4	716	c.187G>T	c.(187-189)GAG>TAG	p.E63*	GNG2_uc001wzh.2_RNA|GNG2_uc010aoc.1_RNA|GNG2_uc001wzj.2_RNA|GNG2_uc001wzk.2_Nonsense_Mutation_p.E63*	NM_053064	NP_444292	P59768	GBG2_HUMAN	guanine nucleotide binding protein (G protein),	63					cellular response to glucagon stimulus|energy reserve metabolic process|platelet activation|synaptic transmission	heterotrimeric G-protein complex	protein binding|signal transducer activity				0	all_epithelial(31;0.0659)|Breast(41;0.0684)				Halothane(DB01159)	CCCGTTTAGGGAGAAGAAGTT	0.522													56	178					6.60958e-23	9.95824e-23	1	0	T	52433376	T	T	52433376	4	4	58	1	0	0	0	0	0	1	0	0	6564	1175	41	2	193	2	GNG2	14	52433376	Nonsense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	10077189	52433376	54916164	411	11796											
NID2	22795	broad.mit.edu	37	chr14	52520339	52520339	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcttccagtcccacctcatAcgtccctcgacttaagggtg	7	11	8	15	2	2	0	1	0	1	0	6	1	5	0	4	1	1	0	4	1	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:52520339A>G	uc001wzo.2	-	5	1621	c.1387T>C	c.(1387-1389)TAT>CAT	p.Y463H	NID2_uc010tqs.1_Missense_Mutation_p.Y463H|NID2_uc010tqt.1_Missense_Mutation_p.Y463H|NID2_uc001wzp.2_Missense_Mutation_p.Y463H	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	463						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CCCACCTCATACGTCCCTCGA	0.478													51	155					0	0	0	0	G	52520339	G	G	52520339	3	3	58	1	0	0	0	0	1	0	0	0	10469	391	14	5	2812	5	NID2	14	52520339	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	86963	52520339	54829201	412	11797											
DDHD1	80821	broad.mit.edu	37	chr14	53518577	53518577	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cataccgagggcattatcttTattctgcattacattttccg	9	16	6	10	2	2	0	0	0	2	0	3	1	3	0	2	1	3	2	2	1	4	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:53518577T>C	uc001xai.2	-	12	2736	c.2506A>G	c.(2506-2508)AAA>GAA	p.K836E	DDHD1_uc001xaj.2_Intron|DDHD1_uc001xah.2_Intron|DDHD1_uc001xag.2_Intron	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	836	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					GCATTATCTTTATTCTGCATT	0.333													2	14					0	0	0	0	C	53518577	C	C	53518577	3	2	58	1	0	0	0	0	1	0	0	0	4343	1763	61	5	204	5	DDHD1	14	53518577	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	998238	53518577	53830963	413	11798											
KIAA0586	9786	broad.mit.edu	37	chr14	58927843	58927843	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctccatctcctaagtccaGaccacagagaccaaaagtaa	15	8	5	13	0	2	2	0	0	2	2	5	3	3	2	5	0	0	1	5	0	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:58927843G>T	uc001xdv.3	+	13	2069	c.1796G>T	c.(1795-1797)AGA>ATA	p.R599I	KIAA0586_uc010trr.1_Missense_Mutation_p.R716I|KIAA0586_uc001xdt.3_Missense_Mutation_p.R631I|KIAA0586_uc001xdu.3_Missense_Mutation_p.R660I|KIAA0586_uc010trs.1_Missense_Mutation_p.R590I|KIAA0586_uc010trt.1_Missense_Mutation_p.R535I|KIAA0586_uc010tru.1_Missense_Mutation_p.R535I	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	599										ovary(1)	1						CCTAAGTCCAGACCACAGAGA	0.328													5	16					1.23904e-05	1.35222e-05	1	0	T	58927843	T	T	58927843	3	4	58	1	0	0	0	0	1	0	0	0	8225	942	33	2	1846	2	KIAA0586	14	58927843	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5409266	58927843	48421697	414	11799											
DACT1	51339	broad.mit.edu	37	chr14	59112685	59112685	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcgctgcctccgaccttcaGagtaagcacctgccaaaaac	11	6	9	15	2	1	1	1	0	0	1	2	2	2	1	5	1	4	3	5	1	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:59112685G>C	uc001xdw.2	+	4	1508	c.1344G>C	c.(1342-1344)CAG>CAC	p.Q448H	DACT1_uc010trv.1_Missense_Mutation_p.Q167H|DACT1_uc001xdx.2_Missense_Mutation_p.Q411H|DACT1_uc010trw.1_Missense_Mutation_p.Q167H	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	448					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CCGACCTTCAGAGTAAGCACC	0.602													15	43					0	0	0	0	C	59112685	C	C	59112685	3	2	58	1	0	0	0	0	1	0	0	0	4239	933	33	2	1358	2	DACT1	14	59112685	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	184842	59112685	48236855	415	11800											
RGS6	9628	broad.mit.edu	37	chr14	72961932	72961932	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctgagccatccaacccttgGatcagcgatgacgttgcttt	8	11	10	12	2	1	2	1	2	0	0	2	4	2	3	3	1	4	3	3	1	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:72961932G>T	uc001xna.3	+	13	1450	c.927G>T	c.(925-927)TGG>TGT	p.W309C	RGS6_uc010ttn.1_Missense_Mutation_p.W309C|RGS6_uc001xmx.3_Missense_Mutation_p.W309C|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.W309C|RGS6_uc010ttp.1_Missense_Mutation_p.W240C|RGS6_uc001xmz.1_Missense_Mutation_p.W170C	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	309	G protein gamma.			W->F: Diminishes interaction with Gbeta5.	G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CCAACCCTTGGATCAGCGATG	0.433													81	201					2.61895e-37	4.25658e-37	1	0	T	72961932	T	T	72961932	3	4	58	1	0	0	0	0	1	0	0	0	13374	1183	41	2	973	2	RGS6	14	72961932	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	13849247	72961932	34387608	416	11801											
NRXN3	9369	broad.mit.edu	37	chr14	79175791	79175791	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagcccaatggcctgatcCtcttcactcatggaaagccc	10	8	8	15	0	3	2	2	1	1	1	4	3	4	3	4	2	2	0	4	2	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:79175791C>A	uc001xun.2	+	4	825	c.334C>A	c.(334-336)CTC>ATC	p.L112I	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.L246I	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	485	Extracellular (Potential).|Laminin G-like 3.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TGGCCTGATCCTCTTCACTCA	0.517													54	127					1.87854e-15	2.54838e-15	1	0	A	79175791	A	A	79175791	3	1	58	1	0	0	0	0	1	0	0	0	10721	681	24	4	340	4	NRXN3	14	79175791	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	6213859	79175791	28173749	417	11802											
RCOR1	23186	broad.mit.edu	37	chr14	103188649	103188649	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatagatgaagttttacaaGaatgggaggcagaacatggt	16	9	12	4	0	0	4	0	1	0	3	0	5	0	5	0	3	2	2	0	3	6	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:103188649G>A	uc001ymb.2	+	11	1306	c.1306G>A	c.(1306-1308)GAA>AAA	p.E436K		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	436					blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						AGTTTTACAAGAATGGGAGGC	0.428													47	135					0	0	0	0	A	103188649	A	A	103188649	3	1	58	1	0	0	0	0	1	0	0	0	13247	943	33	2	1348	2	RCOR1	14	103188649	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	24012858	103188649	4160891	418	11803											
CDC42BPB	9578	broad.mit.edu	37	chr14	103418843	103418843	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aacgacactcaccctcgcagGcgtagccctgccggatcagc	9	5	10	17	4	2	0	2	0	0	0	3	2	2	1	3	2	4	2	3	2	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:103418843G>C	uc001ymi.1	-	24	3396	c.3164C>G	c.(3163-3165)GCC>GGC	p.A1055G	CDC42BPB_uc001ymj.1_Missense_Mutation_p.A157G	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1055	Phorbol-ester/DAG-type.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		ACCCTCGCAGGCGTAGCCCTG	0.637													3	27					0	0	0	0	C	103418843	C	C	103418843	3	2	58	1	0	0	0	0	1	0	0	0	3088	1203	42	4	2027	4	CDC42BPB	14	103418843	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	230194	103418843	3930697	419	11804											
C15orf2	23742	broad.mit.edu	37	chr15	24921750	24921750	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgcccagcacacacagccagGccggatgtgcccggcatctt	8	6	11	16	2	1	0	0	0	1	0	1	1	1	1	4	3	4	2	4	3	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:24921750G>C	uc001ywo.2	+	1	1210	c.736G>C	c.(736-738)GCC>CCC	p.A246P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	246					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		ACACAGCCAGGCCGGATGTGC	0.622													16	45					0	0	0	0	C	24921750	C	C	24921750	3	2	58	1	0	0	0	0	1	0	0	0	1790	1203	42	4	738	4	C15orf2	15	24921750	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08		24921750	77609642	420	11805											
C15orf2	23742	broad.mit.edu	37	chr15	24922585	24922585	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctatgtgtgtggattcccCtcctcctctttccttcctga	4	17	6	14	0	2	1	0	1	2	0	7	2	7	2	6	1	0	0	6	1	1	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:24922585C>G	uc001ywo.2	+	1	2045	c.1571C>G	c.(1570-1572)CCT>CGT	p.P524R		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	524	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GTGGATTCCCCTCCTCCTCTT	0.547													71	281					0	0	0	0	G	24922585	G	G	24922585	3	3	58	1	0	0	0	0	1	0	0	0	1790	681	24	4	1573	4	C15orf2	15	24922585	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	835	24922585	77608807	421	11806											
GABRB3	2562	broad.mit.edu	37	chr15	26793136	26793136	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatcgcccatgcccttctCgaggcatgctctgtttcctg	5	12	10	14	2	2	0	0	0	2	0	5	2	3	1	3	2	2	3	3	2	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:26793136C>A	uc001zaz.2	-	9	1368	c.1226G>T	c.(1225-1227)CGA>CTA	p.R409L	GABRB3_uc010uae.1_Missense_Mutation_p.R324L|GABRB3_uc001zba.2_Missense_Mutation_p.R409L|GABRB3_uc001zbb.2_Missense_Mutation_p.R465L	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	409	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATGCCCTTCTCGAGGCATGCT	0.488													33	93					5.91797e-21	8.74216e-21	1	0	A	26793136	A	A	26793136	3	1	58	1	0	0	0	0	1	0	0	0	6202	884	31	3	199	3	GABRB3	15	26793136	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1870551	26793136	75738256	422	11807											
HERC2	8924	broad.mit.edu	37	chr15	28388011	28388011	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcagctgtttgccaccccTcacaataggatcttcatatt	10	12	7	12	0	3	0	2	0	1	0	3	2	3	1	3	1	3	3	3	1	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:28388011T>A	uc001zbj.2	-	75	11612	c.11506A>T	c.(11506-11508)AGG>TGG	p.R3836W		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3836					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTGCCACCCCTCACAATAGGA	0.408													5	17					0	0	0	0	A	28388011	A	A	28388011	3	1	58	1	0	0	0	0	1	0	0	0	7097	1550	54	5	3074	5	HERC2	15	28388011	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1594875	28388011	74143381	423	11808											
FBN1	2200	broad.mit.edu	37	chr15	48714173	48714173	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaggacgtatggtgttgggTaaatccgggaggacatttgc	9	10	16	6	2	0	0	0	0	0	0	1	3	1	3	1	5	1	4	1	5	3	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:48714173T>A	uc001zwx.1	-	61	7874	c.7546A>T	c.(7546-7548)ACC>TCC	p.T2516S	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2516	EGF-like 43; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGGTGTTGGGTAAATCCGGGA	0.433													14	47					0	0	0	0	A	48714173	A	A	48714173	3	1	58	1	0	0	0	0	1	0	0	0	5734	1638	57	5	1093	5	FBN1	15	48714173	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	20326162	48714173	53817219	424	11809											
CCPG1	9236	broad.mit.edu	37	chr15	55669217	55669217	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaagtcttctgaactctgTgcttcttcaacaatgacaac	12	14	5	10	0	5	2	1	2	4	0	5	2	5	2	0	0	4	1	0	0	6	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:55669217T>C	uc002acv.1	-	5	549	c.384A>G	c.(382-384)GCA>GCG	p.A128A	CCPG1_uc002acy.2_Silent_p.A128A|DYX1C1_uc010ugh.1_RNA|CCPG1_uc002acw.1_5'UTR|CCPG1_uc002acx.2_Silent_p.A128A|CCPG1_uc010bfk.1_Silent_p.A128A|CCPG1_uc002acz.1_Silent_p.A128A	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	128	Cytoplasmic (Potential).|Interaction with MCF2L and SRC (By similarity).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		CTGAACTCTGTGCTTCTTCAA	0.388													43	108					0	0	0	0	C	55669217	C	C	55669217	2	2	58	1	0	0	0	0	0	0	0	1	2953	1683	59	5		5	CCPG1	15	55669217	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	6955044	55669217	46862175	425	11810											
ALDH1A2	8854	broad.mit.edu	37	chr15	58287338	58287338	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggtaaaatagtctccatCtgaaagaaaaaagcatggtc	19	8	8	6	0	2	2	0	1	2	1	4	2	2	2	1	2	1	2	1	2	8	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:58287338C>A	uc002aex.2	-	5	552	c.494_splice	c.e5-1	p.D165_splice	ALDH1A2_uc002aey.2_Splice_Site_p.D165_splice|ALDH1A2_uc010ugv.1_Splice_Site_p.D144_splice|ALDH1A2_uc010ugw.1_Splice_Site_p.D136_splice|ALDH1A2_uc002aew.2_Splice_Site_p.D69_splice	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1						negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TAGTCTCCATCTGAAAGAAAA	0.353													37	108					8.73648e-17	1.20436e-16	1	0	A	58287338	A	A	58287338	5	1	58	1	0	0	0	0	0	0	1	0	491	927	32	2	1099	2	ALDH1A2	15	58287338	Splice_Site	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2618121	58287338	44244054	426	11811											
SLTM	79811	broad.mit.edu	37	chr15	59182658	59182658	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctctctgcaatctctcttCgtctaccaaaaatcagtatt	10	15	3	13	1	6	0	1	0	5	0	9	0	6	0	1	0	2	2	1	0	5	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:59182658C>T	uc002afp.2	-	15	1989	c.1901G>A	c.(1900-1902)CGA>CAA	p.R634Q	SLTM_uc002afn.2_Missense_Mutation_p.R176Q|SLTM_uc002afo.2_Missense_Mutation_p.R616Q|SLTM_uc002afq.2_Missense_Mutation_p.R203Q|SLTM_uc010bgd.2_Missense_Mutation_p.R203Q	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	634	Arg/Glu-rich.|Potential.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						AATCTCTCTTCGTCTACCAAA	0.403													34	128					0	0	0	0	T	59182658	T	T	59182658	3	4	58	1	0	0	0	0	1	0	0	0	14818	884	31	1	1231	1	SLTM	15	59182658	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	895320	59182658	43348734	427	11812											
ZNF609	23060	broad.mit.edu	37	chr15	64967929	64967929	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagttccagtcagcagccctCggtcatccagcagcgtccca	8	7	9	17	2	2	0	2	0	0	0	6	0	5	0	4	1	4	3	4	1	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:64967929C>T	uc002ann.2	+	4	2876	c.2876C>T	c.(2875-2877)TCG>TTG	p.S959L		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	959						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CAGCAGCCCTCGGTCATCCAG	0.507													53	146					0	0	0	0	T	64967929	T	T	64967929	3	4	58	1	0	0	0	0	1	0	0	0	18102	893	31	1	2890	1	ZNF609	15	64967929	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5785271	64967929	37563463	428	11813											
MAP2K5	5607	broad.mit.edu	37	chr15	67873100	67873100	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctctttgcagtattattcCacagtaatggaacagcaagt	13	13	7	8	0	1	0	0	0	1	0	3	1	2	1	1	1	3	4	1	1	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:67873100C>T	uc002aqu.2	+	4	914	c.261C>T	c.(259-261)TCC>TCT	p.S87S	MAP2K5_uc002aqt.1_Silent_p.S87S|MAP2K5_uc002aqv.2_Silent_p.S87S|MAP2K5_uc010ujw.1_Silent_p.S51S	NM_145160	NP_660143	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	87	OPR.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)	2						AGTATTATTCCACAGTAATGG	0.328													41	136					0	0	0	0	T	67873100	T	T	67873100	2	4	58	1	0	0	0	0	0	0	0	1	9293	581	21	4		4	MAP2K5	15	67873100	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2905171	67873100	34658292	429	11814											
HCN4	10021	broad.mit.edu	37	chr15	73659940	73659940	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggagaatttgttgaccccGggttggagcatggccccgaa	9	8	15	9	2	0	2	0	1	0	1	0	5	0	3	4	4	1	3	4	4	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:73659940G>A	uc002avp.2	-	1	1666	c.672C>T	c.(670-672)CCC>CCT	p.P224P		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	224	Involved in subunit assembly (By similarity).|Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		TGTTGACCCCGGGTTGGAGCA	0.652													15	53					0	0	0	0	A	73659940	A	A	73659940	2	1	58	1	0	0	0	0	0	0	0	1	7038	1103	39	1		1	HCN4	15	73659940	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5786840	73659940	28871452	430	11815											
IREB2	3658	broad.mit.edu	37	chr15	78780136	78780136	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atacagcacccttatcagacGcagttttaaatgcagtaaaa	16	10	6	9	1	1	1	1	0	0	1	1	1	1	1	1	0	3	5	1	0	6	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:78780136G>T	uc002bdr.2	+	14	1933	c.1771G>T	c.(1771-1773)GCA>TCA	p.A591S	IREB2_uc010unb.1_Missense_Mutation_p.A341S	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	591							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		CTTATCAGACGCAGTTTTAAA	0.313													16	86					4.96729e-08	5.74317e-08	1	0	T	78780136	T	T	78780136	3	4	58	1	0	0	0	0	1	0	0	0	7865	1087	38	3	1825	3	IREB2	15	78780136	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5120196	78780136	23751256	431	11816											
AGBL1	123624	broad.mit.edu	37	chr15	87089303	87089303	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggctgtagcatcaaggaaaCcttgtggcaagcagcatgca	12	8	12	9	0	1	0	1	0	0	0	1	1	1	1	1	3	5	7	1	3	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:87089303C>G	uc002blz.1	+	19	2698	c.2618C>G	c.(2617-2619)ACC>AGC	p.T873S		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	873					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ATCAAGGAAACCTTGTGGCAA	0.463													7	32					0	0	0	0	G	87089303	G	G	87089303	3	3	58	1	0	0	0	0	1	0	0	0	375	507	18	4	2688	4	AGBL1	15	87089303	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	8309167	87089303	15442089	432	11817											
IGF1R	3480	broad.mit.edu	37	chr15	99456390	99456391	+	Missense_Mutation	DNP	TG	AT	AT																															gagcccggcatcttactacaTgggctgaagccctggactca																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:99456390_99456391TG>AT	uc002bul.2	+	8	1757_1758	c.1707_1708TG>AT	c.(1705-1710)CATGGG>CAATGG	p.569_570HG>QW	IGF1R_uc010urq.1_Missense_Mutation_p.569_570HG>QW|IGF1R_uc010bon.2_Missense_Mutation_p.569_570HG>QW|IGF1R_uc010urr.1_Missense_Mutation_p.19_20HG>QW	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	569_570	Fibronectin type-III 1.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TCTTACTACATGGGCTGAAGCC	0.579													28	65					0	0	0	0	AT	99456391	AT	AT	99456390	3	1	58	1	0	0	0	0	1	0	0	0	7610	1461	51	5	1737	5	IGF1R	15	99456390	Missense_Mutation	DNP	TG	TCGA-CN-5360-01A-01D-1434-08	12367087	99456390	3075002	433	11818											
LYSMD4	145748	broad.mit.edu	37	chr15	100269708	100269708	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatatcctggtcaatcccctTaaagaagcccatcagttggc	12	10	7	12	0	2	1	2	0	0	1	4	1	4	1	4	2	1	1	4	2	6	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:100269708T>A	uc002bvk.2	-	3	574	c.511A>T	c.(511-513)AAG>TAG	p.K171*	LYSMD4_uc002bvj.1_Intron|LYSMD4_uc010bou.1_Intron|LYSMD4_uc002bvl.2_Nonsense_Mutation_p.K172*|LYSMD4_uc002bvm.2_3'UTR|LYSMD4_uc010bov.2_Nonsense_Mutation_p.K171*			Q5XG99	LYSM4_HUMAN	SubName: Full=cDNA FLJ77040, highly similar to Homo sapiens LysM, putative peptidoglycan-binding, domain containing 4, mRNA; SubName: Full=LysM, putative peptidoglycan-binding, domain containing 4, isoform CRA_c;	171	Extracellular (Potential).				cell wall macromolecule catabolic process	integral to membrane					0	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00162)|LUSC - Lung squamous cell carcinoma(107;0.17)|Lung(145;0.208)			TCAATCCCCTTAAAGAAGCCC	0.582													40	103					0	0	0	0	A	100269708	A	A	100269708	4	1	58	1	0	0	0	0	0	1	0	0	9178	1763	61	5	383	5	LYSMD4	15	100269708	Nonsense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	813318	100269708	2261684	434	11819											
RHOT2	89941	broad.mit.edu	37	chr16	720765	720765	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcagtgacgaagagctcaacGctttccaggtgtgcccctgc	8	9	11	13	2	2	2	2	1	0	1	3	3	3	2	3	1	4	2	3	1	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:720765G>C	uc002cip.2	+	9	698	c.631G>C	c.(631-633)GCT>CCT	p.A211P	RHOT2_uc002ciq.2_Missense_Mutation_p.A104P|RHOT2_uc010bqy.2_5'Flank	NM_138769	NP_620124	Q8IXI1	MIRO2_HUMAN	ras homolog gene family, member T2	211	EF-hand 1.|Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			pancreas(1)	1		Hepatocellular(780;0.0218)				AGAGCTCAACGCTTTCCAGGT	0.662													19	39					0	0	0	0	C	720765	C	C	720765	3	2	58	1	0	0	0	0	1	0	0	0	13409	1087	38	3	665	3	RHOT2	16	720765	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08		720765	89633988	435	11820											
NLRC3	197358	broad.mit.edu	37	chr16	3614575	3614575	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagagccggtccagggcgacGgtcctggcggggtgcccgcc	5	4	18	14	5	0	1	0	0	0	1	2	2	2	1	5	6	2	0	5	6	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:3614575G>T	uc010btn.2	-	5	774	c.363C>A	c.(361-363)ACC>ACA	p.T121T		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	121					I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CCAGGGCGACGGTCCTGGCGG	0.706													12	25					1.05317e-09	1.2946e-09	1	0	T	3614575	T	T	3614575	2	4	58	1	0	0	0	0	0	0	0	1	10522	1103	39	3		3	NLRC3	16	3614575	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2893810	3614575	86740178	436	11821											
LITAF	9516	broad.mit.edu	37	chr16	11650502	11650502	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtggggtaataactgttaaCagccactgtctcttcatagg	10	13	10	8	0	2	0	1	0	1	0	3	0	2	0	1	3	3	2	1	3	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:11650502C>A	uc002daz.2	-	2	318	c.85G>T	c.(85-87)GTT>TTT	p.V29F	LITAF_uc002dba.2_Missense_Mutation_p.V29F|LITAF_uc002dbb.2_Missense_Mutation_p.V29F|LITAF_uc002dbc.2_Missense_Mutation_p.V29F|LITAF_uc002dbd.2_Missense_Mutation_p.V29F|LITAF_uc002dbe.3_Missense_Mutation_p.V29F	NM_004862	NP_004853	Q99732	LITAF_HUMAN	lipopolysaccharide-induced TNF-alpha factor	29					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|lysosomal membrane	signal transducer activity|WW domain binding			liver(1)	1						TAACTGTTAACAGCCACTGTC	0.547													27	56					3.80469e-20	5.57204e-20	1	0	A	11650502	A	A	11650502	3	1	58	1	0	0	0	0	1	0	0	0	8872	478	17	4	498	4	LITAF	16	11650502	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	8035927	11650502	78704251	437	11822											
CP110	9738	broad.mit.edu	37	chr16	19557743	19557743	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tattgtgttagagctgctgaAatgggaatgccaaataagaa	15	11	11	4	0	0	3	0	1	0	2	0	4	0	4	1	1	3	3	1	1	7	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:19557743A>C	uc002dgl.3	+	12	3034	c.2787A>C	c.(2785-2787)GAA>GAC	p.E929D	CP110_uc002dgk.3_Missense_Mutation_p.E929D			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	929					centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						GAGCTGCTGAAATGGGAATGC	0.303													18	44					0	0	0	0	C	19557743	C	C	19557743	3	2	58	1	0	0	0	0	1	0	0	0	3803	11	1	5	2829	5	CP110	16	19557743	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	7907241	19557743	70797010	438	11823											
PDILT	204474	broad.mit.edu	37	chr16	20410587	20410587	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggacagcagagacacaagcGgccaccagcagcaggggcat	13	2	14	12	1	0	1	0	0	0	1	0	3	0	2	2	4	4	4	2	4	1	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:20410587G>T	uc002dhc.1	-	2	259	c.36C>A	c.(34-36)GCC>GCA	p.A12A		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	12					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						AGACACAAGCGGCCACCAGCA	0.592													15	103					5.01169e-05	5.37475e-05	1	0	T	20410587	T	T	20410587	2	4	58	1	0	0	0	0	0	0	0	1	11728	1103	39	3		3	PDILT	16	20410587	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	852844	20410587	69944166	439	11824											
ACSM2B	348158	broad.mit.edu	37	chr16	20570737	20570737	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccccttcccattcacccaCcacagggctgggcttgggag	6	9	10	16	0	1	0	1	0	0	0	3	1	3	1	5	3	0	2	5	3	0	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:20570737C>A	uc002dhj.3	-	4	420	c.210G>T	c.(208-210)TGG>TGT	p.W70C	ACSM2B_uc002dhk.3_Missense_Mutation_p.W70C|ACSM2B_uc010bwf.1_Missense_Mutation_p.W70C	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	70					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CATTCACCCACCACAGGGCTG	0.532													8	27					3.86212e-05	4.14843e-05	1	0	A	20570737	A	A	20570737	3	1	58	1	0	0	0	0	1	0	0	0	184	508	18	4	1571	4	ACSM2B	16	20570737	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	160150	20570737	69784016	440	11825											
LOC81691	81691	broad.mit.edu	37	chr16	20824541	20824541	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatctaccattttatttacTgacaactgtgaagtaaccca	13	15	4	9	0	1	2	0	2	1	0	1	2	1	2	2	0	4	1	2	0	7	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:20824541T>C	uc002dhv.2	+	3	431	c.168T>C	c.(166-168)ACT>ACC	p.T56T	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Silent_p.T56T|LOC81691_uc002dhw.2_5'UTR|LOC81691_uc002dhy.3_Silent_p.T56T	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	56						nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						TTTTATTTACTGACAACTGTG	0.383													23	58					0	0	0	0	C	20824541	C	C	20824541	2	2	58	1	0	0	0	0	0	0	0	1	8940	1567	55	5		5	LOC81691	16	20824541	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	253804	20824541	69530212	441	11826											
DNAH3	55567	broad.mit.edu	37	chr16	21038393	21038393	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctcgaggtcggcgggctcGaagatcaggctcatcttgga	7	9	15	10	4	3	1	2	0	1	1	6	4	3	2	0	5	1	3	0	5	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:21038393G>A	uc010vbe.1	-	38	5496	c.5496C>T	c.(5494-5496)TTC>TTT	p.F1832F		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1832	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CGGCGGGCTCGAAGATCAGGC	0.572													10	40					0	0	0	0	A	21038393	A	A	21038393	2	1	58	1	0	0	0	0	0	0	0	1	4625	1049	37	1		1	DNAH3	16	21038393	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	213852	21038393	69316360	442	11827											
DNAH3	55567	broad.mit.edu	37	chr16	21117970	21117970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacctcactgactttgtctgCgatgtggctgtactgattac	8	14	9	10	1	2	2	1	2	1	0	2	3	2	2	1	1	4	2	1	1	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:21117970C>T	uc010vbe.1	-	15	2125	c.2125G>A	c.(2125-2127)GCA>ACA	p.A709T	DNAH3_uc002die.2_Missense_Mutation_p.A649T	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	709	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ACTTTGTCTGCGATGTGGCTG	0.353													17	75					0	0	0	0	T	21117970	T	T	21117970	3	4	58	1	0	0	0	0	1	0	0	0	4625	768	27	1	10416	1	DNAH3	16	21117970	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	79577	21117970	69236783	443	11828											
RBBP6	5930	broad.mit.edu	37	chr16	24581745	24581745	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctagcaaagttaaacaagAaaaagtcaaaggaaaggtca	22	6	8	5	0	3	1	2	0	1	1	3	2	3	2	0	2	2	2	0	2	9	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:24581745A>C	uc002dmh.2	+	17	4774	c.3734A>C	c.(3733-3735)GAA>GCA	p.E1245A	RBBP6_uc010vcb.1_Missense_Mutation_p.E1112A|RBBP6_uc002dmi.2_Missense_Mutation_p.E1211A|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.E1078A	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1245					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GTTAAACAAGAAAAAGTCAAA	0.408													16	56					0	0	0	0	C	24581745	C	C	24581745	3	2	58	1	0	0	0	0	1	0	0	0	13168	246	9	5	3854	5	RBBP6	16	24581745	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	3463775	24581745	65773008	444	11829											
GTF3C1	2975	broad.mit.edu	37	chr16	27556684	27556684	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctgcaaggacttggttcTgatgtcattggtaatgtttt	8	16	12	5	0	2	1	1	1	1	0	2	2	2	2	0	4	1	5	0	4	2	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:27556684T>C	uc002dov.1	-	2	422	c.382A>G	c.(382-384)AGA>GGA	p.R128G	GTF3C1_uc002dou.2_Missense_Mutation_p.R128G	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	128						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GACTTGGTTCTGATGTCATTG	0.418													66	179					0	0	0	0	C	27556684	C	C	27556684	3	2	58	1	0	0	0	0	1	0	0	0	6911	1588	55	5	6091	5	GTF3C1	16	27556684	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	2974939	27556684	62798069	445	11830											
ZNF668	79759	broad.mit.edu	37	chr16	31072937	31072937	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgaactctcacctgccaCgcccacaggcagcgccaacc	9	4	9	19	2	1	1	1	1	1	0	2	1	1	1	5	2	4	2	5	2	2	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:31072937C>A	uc010caf.2	-	3	1669	c.1312G>T	c.(1312-1314)GTG>TTG	p.V438L	ZNF668_uc002eao.2_Missense_Mutation_p.V438L	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						TCACCTGCCACGCCCACAGGC	0.716													26	88					4.02929e-09	4.83941e-09	1	0	A	31072937	A	A	31072937	3	1	58	1	0	0	0	0	1	0	0	0	18142	536	19	3	551	3	ZNF668	16	31072937	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3516253	31072937	59281816	446	11831											
IRX5	10265	broad.mit.edu	37	chr16	54965210	54965210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcatttcggggccccgcacgGatgagctcggccgctcttct	4	10	12	15	5	3	1	1	1	2	0	5	2	3	2	3	4	1	3	3	4	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:54965210G>A	uc002ehv.2	+	1	100	c.100G>A	c.(100-102)GAT>AAT	p.D34N	uc010vhb.1_5'Flank|uc010vhc.1_5'Flank|uc002ehu.1_5'Flank|IRX5_uc010cca.1_Missense_Mutation_p.D34N|IRX5_uc002ehw.2_5'Flank	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	34					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						GCCCCGCACGGATGAGCTCGG	0.672													11	22					0	0	0	0	A	54965210	A	A	54965210	3	1	58	1	0	0	0	0	1	0	0	0	7886	1174	41	2	102	2	IRX5	16	54965210	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	23892273	54965210	35389543	447	11832											
CIRH1A	84916	broad.mit.edu	37	chr16	69184450	69184450	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aattcctcagcaagaagacaGtttcgtggtgggcacagccg	11	8	12	10	2	1	2	1	0	0	2	3	2	2	2	2	2	2	3	2	2	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:69184450G>T	uc002ews.3	+	7	845	c.749G>T	c.(748-750)AGT>ATT	p.S250I	CIRH1A_uc002ewr.2_Missense_Mutation_p.S250I|CIRH1A_uc002ewt.3_Missense_Mutation_p.S167I|CIRH1A_uc010cfi.2_Missense_Mutation_p.S167I|CIRH1A_uc010cfj.1_Missense_Mutation_p.S69I	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	250	WD 6.					nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		CAAGAAGACAGTTTCGTGGTG	0.488											OREG0023906	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	152					0.00909568	0.00927269	1	0	T	69184450	T	T	69184450	3	4	58	1	0	0	0	0	1	0	0	0	3449	1029	36	4	771	4	CIRH1A	16	69184450	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	14219240	69184450	21170303	448	11833											
NFAT5	10725	broad.mit.edu	37	chr16	69726060	69726060	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacagcagcagatttcatcaAatatttttccatcaccaaat	15	13	3	10	0	3	1	3	0	0	1	4	1	4	1	2	0	3	2	2	0	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:69726060A>G	uc002exm.1	+	12	3486	c.2278A>G	c.(2278-2280)AAT>GAT	p.N760D	NFAT5_uc002exi.2_Missense_Mutation_p.N684D|NFAT5_uc002exj.1_Missense_Mutation_p.N684D|NFAT5_uc002exk.1_Missense_Mutation_p.N684D|NFAT5_uc002exl.1_Missense_Mutation_p.N778D|NFAT5_uc002exn.1_Missense_Mutation_p.N777D|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	760					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GATTTCATCAAATATTTTTCC	0.443													4	65					0	0	0	0	G	69726060	G	G	69726060	3	3	58	1	0	0	0	0	1	0	0	0	10414	14	1	5	2382	5	NFAT5	16	69726060	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	541610	69726060	20628693	449	11834											
HSD17B2	3294	broad.mit.edu	37	chr16	82131825	82131825	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaactcgttagccagcaaGgacttctctccggtgctgcg	8	10	10	13	3	2	0	1	0	1	0	5	1	3	1	2	2	5	3	2	2	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:82131825G>A	uc002fgv.2	+	5	1120	c.948G>A	c.(946-948)AAG>AAA	p.K316K		NM_002153	NP_002144	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	316					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			ovary(1)|central_nervous_system(1)	2					NADH(DB00157)	TAGCCAGCAAGGACTTCTCTC	0.542													39	73					0	0	0	0	A	82131825	A	A	82131825	2	1	58	1	0	0	0	0	0	0	0	1	7423	991	35	4		4	HSD17B2	16	82131825	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	12405765	82131825	8222928	450	11835											
TEKT1	83659	broad.mit.edu	37	chr17	6718618	6718618	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagattgtacttggcagagcGgttcatcctgaagggagaaa	13	9	13	6	1	1	4	1	1	0	3	2	5	2	4	1	3	2	3	1	3	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:6718618G>T	uc002gdt.2	-	5	603	c.493C>A	c.(493-495)CGC>AGC	p.R165S	TEKT1_uc010vth.1_Missense_Mutation_p.R19S	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	165	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				TTGGCAGAGCGGTTCATCCTG	0.498													34	72					8.4185e-14	1.11973e-13	1	0	T	6718618	T	T	6718618	3	4	58	1	0	0	0	0	1	0	0	0	15818	1116	39	3	779	3	TEKT1	17	6718618	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08		6718618	74476592	451	11836											
SLC2A4	6517	broad.mit.edu	37	chr17	7188426	7188426	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgttgttggtggagcgggCggggcgccggacgctccatc	3	8	20	10	5	0	0	0	0	0	0	2	2	1	2	2	7	1	3	2	7	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:7188426C>A	uc002gfp.2	+	9	1240	c.1040C>A	c.(1039-1041)GCG>GAG	p.A347E	SLC2A4_uc002gfo.2_Missense_Mutation_p.A347E|SLC2A4_uc010cmd.2_RNA	NM_001042	NP_001033	P14672	GTR4_HUMAN	glucose transporter 4	347	Cytoplasmic (Potential).				carbohydrate metabolic process|glucose homeostasis|glucose import	external side of plasma membrane|integral to plasma membrane|perinuclear region of cytoplasm	D-glucose transmembrane transporter activity|protein binding				0						GTGGAGCGGGCGGGGCGCCGG	0.667													10	7					0.000442599	0.000468756	1	0	A	7188426	A	A	7188426	3	1	58	1	0	0	0	0	1	0	0	0	14610	768	27	3	1074	3	SLC2A4	17	7188426	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	469808	7188426	74006784	452	11837											
TP53	7157	broad.mit.edu	37	chr17	7578474	7578474	+	Frame_Shift_Del	DEL	C	-	-																															gcgcggacgcgggtgccgggCgggggtgtggaatcaaccca																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:7578474delC	uc002gim.2	-	5	650	c.456delG	c.(454-456)CCGfs	p.P152fs	TP53_uc002gig.1_Frame_Shift_Del_p.P152fs|TP53_uc002gih.2_Frame_Shift_Del_p.P152fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.P20fs|TP53_uc010cng.1_Frame_Shift_Del_p.P20fs|TP53_uc002gii.1_Frame_Shift_Del_p.P20fs|TP53_uc010cnh.1_Frame_Shift_Del_p.P152fs|TP53_uc010cni.1_Frame_Shift_Del_p.P152fs|TP53_uc002gij.2_Frame_Shift_Del_p.P152fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.P59fs|TP53_uc002gio.2_Frame_Shift_Del_p.P20fs|TP53_uc010vug.1_Frame_Shift_Del_p.P113fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	152	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P152L(57)|p.P152S(21)|p.P152fs*18(17)|p.P153fs*28(8)|p.P152T(7)|p.0?(7)|p.P152fs*29(5)|p.P152P(5)|p.P152Q(4)|p.P152fs*14(4)|p.P152fs*28(3)|p.P152R(3)|p.T150fs*16(3)|p.P152A(2)|p.P153fs*16(1)|p.P151_V173del23(1)|p.P152_P153del(1)|p.G154fs*16(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P153fs*20(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.G154fs*27(1)|p.P152_P153insXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGTGCCGGGCGGGGGTGTGG	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578474	-	-	7578474	7	5	58	1	0	1	0	1	0	0	0	0	16448	755	27	0	842	0	TP53	17	7578474	Frame_Shift_Del	DEL	C	TCGA-CN-5360-01A-01D-1434-08	390048	7578474	73616736	453	11838											
MFSD6L	162387	broad.mit.edu	37	chr17	8702310	8702310	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcccacccagggcgcggcCaagcccagctgcctcaggta	7	4	13	17	2	1	0	1	0	0	0	1	0	1	0	5	3	4	2	5	3	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:8702310C>A	uc002glp.1	-	1	277	c.129G>T	c.(127-129)TTG>TTT	p.L43F		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	43						integral to membrane				central_nervous_system(1)	1						AGGGCGCGGCCAAGCCCAGCT	0.652													18	40					1.67942e-08	1.97869e-08	1	0	A	8702310	A	A	8702310	3	1	58	1	0	0	0	0	1	0	0	0	9589	593	21	4	1635	4	MFSD6L	17	8702310	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1123836	8702310	72492900	454	11839											
GLP2R	9340	broad.mit.edu	37	chr17	9792733	9792733	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccgcttcttgctagcccGccactcaggctgcagagcct	5	9	11	16	2	2	1	1	0	1	1	3	1	3	1	4	2	4	4	4	2	1	3	rs143908746	byFrequency	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:9792733G>T	uc002gmd.1	+	13	1373	c.1373G>T	c.(1372-1374)CGC>CTC	p.R458L		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	458	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	TTGCTAGCCCGCCACTCAGGC	0.562													16	31					1.37285e-15	1.86983e-15	1	0	T	9792733	T	T	9792733	3	4	58	1	0	0	0	0	1	0	0	0	6490	1087	38	3	1423	3	GLP2R	17	9792733	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1090423	9792733	71402477	455	11840											
MYH1	4619	broad.mit.edu	37	chr17	10402013	10402013	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcctccactgggcaacctCactgttggccttggacattg	6	11	11	13	0	1	0	1	0	0	0	3	1	3	1	4	4	1	2	4	4	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:10402013C>T	uc002gmo.2	-	30	4205	c.4111G>A	c.(4111-4113)GAG>AAG	p.E1371K	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1371	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TGGGCAACCTCACTGTTGGCC	0.547													49	109					0	0	0	0	T	10402013	T	T	10402013	3	4	58	1	0	0	0	0	1	0	0	0	10082	835	29	2	1752	2	MYH1	17	10402013	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	609280	10402013	70793197	456	11841											
MYH2	4620	broad.mit.edu	37	chr17	10427956	10427956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttcaggtcctcctggctccGgagagcatcatccaggtgga	7	9	12	13	1	2	1	2	0	0	1	6	3	6	2	4	5	1	2	4	5	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:10427956G>A	uc010coi.2	-	35	5130	c.5002C>T	c.(5002-5004)CGG>TGG	p.R1668W	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1668W|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1668	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCCTGGCTCCGGAGAGCATCA	0.572													21	50					0	0	0	0	A	10427956	A	A	10427956	3	1	58	1	0	0	0	0	1	0	0	0	10088	1115	39	1	847	1	MYH2	17	10427956	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	25943	10427956	70767254	457	11842											
MYH2	4620	broad.mit.edu	37	chr17	10429159	10429159	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttcacagcttctacatgttCctcagctgcctgcagccgct	6	12	8	15	1	3	0	2	0	1	0	4	0	4	0	3	0	6	6	3	0	1	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:10429159C>T	uc010coi.2	-	31	4350	c.4222G>A	c.(4222-4224)GAA>AAA	p.E1408K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E1408K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1408	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCTACATGTTCCTCAGCTGCC	0.483													21	44					0	0	0	0	T	10429159	T	T	10429159	3	4	58	1	0	0	0	0	1	0	0	0	10088	864	30	2	1643	2	MYH2	17	10429159	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1203	10429159	70766051	458	11843											
DNAH9	1770	broad.mit.edu	37	chr17	11833273	11833273	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccagagttcagggtcttcAtgagtgcagagccagcaccc	10	7	11	13	0	3	3	2	1	1	2	3	3	3	3	3	1	3	3	3	1	0	2	rs141342607		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:11833273A>T	uc002gne.2	+	63	12036	c.11968A>T	c.(11968-11970)ATG>TTG	p.M3990L	DNAH9_uc010coo.2_Intron|DNAH9_uc002gnf.2_Missense_Mutation_p.M302L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3990	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAGGGTCTTCATGAGTGCAGA	0.582													11	21					0	0	0	0	T	11833273	T	T	11833273	3	4	58	1	0	0	0	0	1	0	0	0	4630	217	8	5	12218	5	DNAH9	17	11833273	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	1404114	11833273	69361937	459	11844											
MYOCD	93649	broad.mit.edu	37	chr17	12649298	12649298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aacgccactgagcaatacccCcttgtctcctgtcaaaaaca	13	8	5	15	1	2	1	1	1	1	0	3	1	2	1	4	0	4	1	4	0	5	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:12649298C>T	uc002gnn.2	+	9	1333	c.1034C>T	c.(1033-1035)CCC>CTC	p.P345L	MYOCD_uc002gno.2_Missense_Mutation_p.P345L|MYOCD_uc002gnp.1_Missense_Mutation_p.P249L|MYOCD_uc002gnq.2_Missense_Mutation_p.P64L	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	345					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGCAATACCCCCTTGTCTCCT	0.423													76	146					0	0	0	0	T	12649298	T	T	12649298	3	4	58	1	0	0	0	0	1	0	0	0	10140	623	22	4	1068	4	MYOCD	17	12649298	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	816025	12649298	68545912	460	11845											
ZNF286B	729288	broad.mit.edu	37	chr17	18566461	18566461	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgaagttgaatccttgcTctgtggtctagtctccacgt	7	14	9	11	1	3	2	0	2	3	0	5	2	4	2	2	1	1	2	2	1	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:18566461T>A	uc010vyd.1	-	5	609	c.358A>T	c.(358-360)AGC>TGC	p.S120C		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAATCCTTGCTCTGTGGTCTA	0.388													27	45					0	0	0	0	A	18566461	A	A	18566461	3	1	58	1	0	0	0	0	1	0	0	0	17891	1551	54	5	1214	5	ZNF286B	17	18566461	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	5917163	18566461	62628749	461	11846											
RAB34	83871	broad.mit.edu	37	chr17	27041920	27041920	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattctcggacattctcaccTgacacagagagcagataggt	13	9	9	10	1	2	3	1	1	2	2	4	5	2	4	1	2	1	1	1	2	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:27041920T>A	uc002hce.2	-	9	1229	c.605_splice	c.e9-1	p.G202_splice	RAB34_uc002hcg.2_Splice_Site_p.G194_splice|RAB34_uc002hcf.2_Splice_Site_p.G203_splice|RAB34_uc010was.1_Splice_Site_p.G259_splice|RAB34_uc010wat.1_Splice_Site_p.G251_splice|RAB34_uc002hch.2_Splice_Site_p.G202_splice|RAB34_uc010wau.1_Splice_Site_p.G180_splice|RAB34_uc010wav.1_Intron	NM_031934	NP_114140	Q9BZG1	RAB34_HUMAN	Ras-related protein RAB34 isoform 1						protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	Lung NSC(42;0.00431)					CATTCTCACCTGACACAGAGA	0.587													12	54					0	0	0	0	A	27041920	A	A	27041920	5	1	58	1	0	0	0	0	0	0	1	0	12989	1594	55	5	248	5	RAB34	17	27041920	Splice_Site	SNP	T	TCGA-CN-5360-01A-01D-1434-08	8475459	27041920	54153290	462	11847											
KRT12	3859	broad.mit.edu	37	chr17	39022952	39022952	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcagtcccagttcctcgtgTttcataccattctcgaattt	7	16	6	12	2	2	0	1	0	1	0	6	1	4	0	3	0	2	3	3	0	2	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:39022952T>A	uc002hvk.2	-	1	511	c.487A>T	c.(487-489)ACA>TCA	p.T163S		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	163	Rod.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GTTCCTCGTGTTTCATACCAT	0.408													54	208					0	0	0	0	A	39022952	A	A	39022952	3	1	58	1	0	0	0	0	1	0	0	0	8488	1725	60	5	1029	5	KRT12	17	39022952	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	11981032	39022952	42172258	463	11848											
HAP1	9001	broad.mit.edu	37	chr17	39881020	39881020	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccccgtgggggcactcacctTtctggagcatcttccacctc	5	10	9	17	1	3	0	1	0	2	0	5	1	4	1	5	3	1	2	5	3	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:39881020T>C	uc002hxm.1	-	12	1961	c.1949A>G	c.(1948-1950)AAA>AGA	p.K650R	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Missense_Mutation_p.K598R|HAP1_uc002hxo.1_Missense_Mutation_p.K581R|HAP1_uc002hxp.1_Missense_Mutation_p.K573R	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	650					brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			GCACTCACCTTTCTGGAGCAT	0.602													57	188					0	0	0	0	C	39881020	C	C	39881020	3	2	58	1	0	0	0	0	1	0	0	0	6992	1841	64	5	70	5	HAP1	17	39881020	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	858068	39881020	41314190	464	11849											
LPO	4025	broad.mit.edu	37	chr17	56344747	56344747	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttctgtgacctctcacaGccgcagacactagaggagtt	9	9	10	13	1	2	3	1	1	2	2	3	4	2	4	3	1	1	2	3	1	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:56344747G>A	uc002ivt.2	+	12	2047	c.1731G>A	c.(1729-1731)CAG>CAA	p.Q577Q	LPO_uc010wns.1_Silent_p.Q518Q|LPO_uc010dcp.2_Silent_p.Q494Q|LPO_uc010dcq.2_Silent_p.Q248Q|LPO_uc010dcr.2_Silent_p.Q140Q	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	577					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						ACCTCTCACAGCCGCAGACAC	0.552													16	60					0	0	0	0	A	56344747	A	A	56344747	2	1	58	1	0	0	0	0	0	0	0	1	8972	962	34	4		4	LPO	17	56344747	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	16463727	56344747	24850463	465	11850											
BZRAP1	9256	broad.mit.edu	37	chr17	56386506	56386506	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaagggacactggccaggtCttcggggctgaccactgtca	9	7	13	12	1	2	1	1	1	1	0	3	2	2	2	2	5	0	1	2	5	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:56386506C>T	uc002ivx.3	-	22	4998	c.4127G>A	c.(4126-4128)AGA>AAA	p.R1376K	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Missense_Mutation_p.R1316K|BZRAP1_uc010wnt.1_Missense_Mutation_p.R1376K	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1376						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGGCCAGGTCTTCGGGGCTG	0.587													47	121					0	0	0	0	T	56386506	T	T	56386506	3	4	58	1	0	0	0	0	1	0	0	0	1582	913	32	2	1486	2	BZRAP1	17	56386506	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	41759	56386506	24808704	466	11851											
PRR11	55771	broad.mit.edu	37	chr17	57270975	57270975	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaaagctgtgcttcctccCacactgccacagccagccag	9	7	7	18	0	0	0	0	0	0	0	3	0	3	0	6	0	5	2	6	0	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:57270975C>A	uc002ixf.1	+	5	604	c.525C>A	c.(523-525)CCC>CCA	p.P175P	PRR11_uc002ixg.1_RNA	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	proline rich 11	175	Pro-rich.									ovary(2)	2	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TGCTTCCTCCCACACTGCCAC	0.423													17	32					2.23348e-06	2.47318e-06	1	0	A	57270975	A	A	57270975	2	1	58	1	0	0	0	0	0	0	0	1	12645	581	21	4		4	PRR11	17	57270975	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	884469	57270975	23924235	467	11852											
MED13	9969	broad.mit.edu	37	chr17	60130054	60130054	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaagtccattctcccacactCcatcttcttcttctaaaaga	12	13	2	14	0	5	1	0	0	5	1	8	1	7	1	3	0	0	0	3	0	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:60130054C>T	uc002izo.2	-	3	391	c.314G>A	c.(313-315)GGA>GAA	p.G105E		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	105					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						CTCCCACACTCCATCTTCTTC	0.338													44	181					0	0	0	0	T	60130054	T	T	60130054	3	4	58	1	0	0	0	0	1	0	0	0	9483	855	30	2	6322	2	MED13	17	60130054	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2859079	60130054	21065156	468	11853											
KCNH6	81033	broad.mit.edu	37	chr17	61623183	61623183	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcttctcctccctccctgaaCaccttggctctgttcccaag	5	12	6	18	0	2	1	0	1	2	0	6	1	5	1	5	1	1	3	5	1	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:61623183C>A	uc002jay.2	+	14	2985	c.2905C>A	c.(2905-2907)CAC>AAC	p.H969N	KCNH6_uc010wpl.1_Missense_Mutation_p.H810N|KCNH6_uc010wpm.1_Missense_Mutation_p.H933N|KCNH6_uc002jaz.1_Missense_Mutation_p.H880N	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	969	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCTCCCTGAACACCTTGGCTC	0.567													38	130					6.99958e-10	8.66675e-10	1	0	A	61623183	A	A	61623183	3	1	58	1	0	0	0	0	1	0	0	0	8075	478	17	4	2959	4	KCNH6	17	61623183	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1493129	61623183	19572027	469	11854											
APOH	350	broad.mit.edu	37	chr17	64225441	64225441	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaagtacttactccgtccTgcaatagcaacatggcagag	15	8	8	10	1	0	1	0	0	0	1	2	1	2	1	2	1	5	4	2	1	7	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:64225441T>A	uc002jfn.3	-	1	116	c.57A>T	c.(55-57)GCA>GCT	p.A19A		NM_000042	NP_000033	P02749	APOH_HUMAN	apolipoprotein H precursor	19					blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding				0			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			TACTCCGTCCTGCAATAGCAA	0.363													6	14					0	0	0	0	A	64225441	A	A	64225441	2	1	58	1	0	0	0	0	0	0	0	1	804	1567	55	5		5	APOH	17	64225441	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	2602258	64225441	16969769	470	11855											
MAP2K6	5608	broad.mit.edu	37	chr17	67516411	67516411	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgaaacaattggtctccagGgtgatgtgtggatctgcatg	9	12	13	7	0	2	2	0	2	2	0	3	3	2	3	1	3	2	1	1	3	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:67516411G>T	uc002jij.2	+	6	655	c.367G>T	c.(367-369)GGT>TGT	p.G123C	MAP2K6_uc002jii.2_Missense_Mutation_p.G123C|MAP2K6_uc002jik.2_3'UTR	NM_002758	NP_002749	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	123	Protein kinase.				activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|pancreas(1)	5	Breast(10;6.05e-10)					TGGTCTCCAGGGTGATGTGTG	0.343													26	53					1.5548e-18	2.20587e-18	1	0	T	67516411	T	T	67516411	3	4	58	1	0	0	0	0	1	0	0	0	9294	1246	43	4	389	4	MAP2K6	17	67516411	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3290970	67516411	13678799	471	11856											
RHBDF2	79651	broad.mit.edu	37	chr17	74473293	74473293	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caccccatcgggggagacagGggaggctgagtgtgggatcc	8	5	18	10	1	0	2	0	1	0	1	2	5	1	4	3	6	0	1	3	6	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:74473293G>A	uc002jrq.1	-	8	1269	c.976C>T	c.(976-978)CCT>TCT	p.P326S	RHBDF2_uc002jrp.1_Missense_Mutation_p.P297S|RHBDF2_uc002jrr.1_Missense_Mutation_p.P178S|RHBDF2_uc010wtf.1_Missense_Mutation_p.P297S|RHBDF2_uc002jrs.1_Missense_Mutation_p.P321S	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	326	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						GGGGAGACAGGGGAGGCTGAG	0.632													5	11					0	0	0	0	A	74473293	A	A	74473293	3	1	58	1	0	0	0	0	1	0	0	0	13385	1232	43	4	1642	4	RHBDF2	17	74473293	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6956882	74473293	6721917	472	11857											
ENPP7	339221	broad.mit.edu	37	chr17	77709217	77709217	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacaaacgggctggcgacCtggttgaattccacaagttc	10	9	12	10	2	0	1	0	1	0	0	2	3	1	2	2	4	1	3	2	4	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:77709217C>A	uc002jxa.2	+	3	795	c.775C>A	c.(775-777)CTG>ATG	p.L259M		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	259					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGCTGGCGACCTGGTTGAATT	0.587													16	86					1.5739e-10	1.97389e-10	1	0	A	77709217	A	A	77709217	3	1	58	1	0	0	0	0	1	0	0	0	5159	680	24	4	785	4	ENPP7	17	77709217	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3235924	77709217	3485993	473	11858											
B3GNTL1	146712	broad.mit.edu	37	chr17	80972342	80972342	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtacttacgctcgacgggtgCtgaacggcagcctcgtgttg	6	10	14	11	5	0	1	0	1	0	0	2	2	0	1	1	2	5	5	1	2	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:80972342C>A	uc002kgg.1	-	5	410	c.396G>T	c.(394-396)CAG>CAT	p.Q132H	B3GNTL1_uc002kgf.1_5'UTR	NM_001009905	NP_001009905	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal	132							transferase activity, transferring glycosyl groups			ovary(1)|pancreas(1)	2	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			TCGACGGGTGCTGAACGGCAG	0.468													10	56					1.58986e-06	1.76911e-06	1	0	A	80972342	A	A	80972342	3	1	58	1	0	0	0	0	1	0	0	0	1267	796	28	4	721	4	B3GNTL1	17	80972342	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3263125	80972342	222868	474	11859											
TMEM200C	645369	broad.mit.edu	37	chr18	5891898	5891898	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accaggatcccacagagggcGatgagccctgagatggagca	12	4	14	11	1	0	3	0	2	0	2	1	7	1	5	3	3	2	1	3	3	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:5891898G>A	uc002kmx.1	-	1	206	c.165C>T	c.(163-165)ATC>ATT	p.I55I		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	55	Helical; (Potential).					integral to membrane					0						CACAGAGGGCGATGAGCCCTG	0.627													13	36					0	0	0	0	A	5891898	A	A	5891898	2	1	58	1	0	0	0	0	0	0	0	1	16191	1048	37	1		1	TMEM200C	18	5891898	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08		5891898	72185350	475	11860											
LAMA1	284217	broad.mit.edu	37	chr18	7079977	7079977	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctgggctcacctacctgTcttaagtccagagtgattgt	7	14	10	10	0	3	2	1	1	2	1	4	2	4	2	3	1	1	2	3	1	2	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:7079977T>A	uc002knm.2	-	3	436	c.342A>T	c.(340-342)AGA>AGT	p.R114S	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	114	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACCTACCTGTCTTAAGTCCA	0.468													13	49					0	0	0	0	A	7079977	A	A	7079977	3	1	58	1	0	0	0	0	1	0	0	0	8645	1664	58	5	9129	5	LAMA1	18	7079977	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	1188079	7079977	70997271	476	11861											
MPPE1	65258	broad.mit.edu	37	chr18	11888679	11888679	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatactcacttaatgcctttCcaagaaaacagtctttcaga	15	12	4	10	0	3	2	2	0	1	2	4	2	4	2	2	0	3	0	2	0	6	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:11888679C>T	uc002kqf.2	-	6	1199	c.558G>A	c.(556-558)TGG>TGA	p.W186*	MPPE1_uc002kqn.2_Nonsense_Mutation_p.W186*|MPPE1_uc002kqg.2_RNA|MPPE1_uc002kqh.2_RNA|MPPE1_uc002kqi.2_RNA|MPPE1_uc002kqj.2_Nonsense_Mutation_p.W186*|MPPE1_uc002kqk.2_Nonsense_Mutation_p.W186*|MPPE1_uc002kql.2_Nonsense_Mutation_p.W186*|MPPE1_uc002kqm.2_Nonsense_Mutation_p.W186*|MPPE1_uc010dla.1_Nonsense_Mutation_p.W186*	NM_023075	NP_075563	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1 precursor	186					ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0						TAATGCCTTTCCAAGAAAACA	0.353													9	31					0	0	0	0	T	11888679	T	T	11888679	4	4	58	1	0	0	0	0	0	1	0	0	9793	856	30	2	656	2	MPPE1	18	11888679	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	4808702	11888679	66188569	477	11862											
POTEC	388468	broad.mit.edu	37	chr18	14537970	14537970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcatcttcctggcattgtaCggcctgtcagtattagacca	8	14	8	11	1	3	1	2	0	1	1	4	1	4	1	3	2	1	3	3	2	3	6	rs148283099	by1000genomes	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:14537970C>T	uc010dln.2	-	3	1094	c.640G>A	c.(640-642)GTA>ATA	p.V214I	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	214	ANK 3.									skin(3)	3						TGGCATTGTACGGCCTGTCAG	0.358													6	159					0	0	0	0	T	14537970	T	T	14537970	3	4	58	1	0	0	0	0	1	0	0	0	12317	536	19	1	1024	1	POTEC	18	14537970	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2649291	14537970	63539278	478	11863											
FAM59A	64762	broad.mit.edu	37	chr18	29848468	29848468	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcaaaatcaaaaggtgctGggcagtttctctttggtgtg	10	13	11	7	0	3	0	2	0	1	0	4	0	3	0	0	3	1	3	0	3	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:29848468G>A	uc002kxl.2	-	6	2053	c.1997C>T	c.(1996-1998)CCA>CTA	p.P666L	FAM59A_uc002kxk.1_Missense_Mutation_p.P665L	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	666										ovary(1)|skin(1)	2						AAAAGGTGCTGGGCAGTTTCT	0.532													28	76					0	0	0	0	A	29848468	A	A	29848468	3	1	58	1	0	0	0	0	1	0	0	0	5624	1348	47	4	637	4	FAM59A	18	29848468	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	15310498	29848468	48228780	479	11864											
SYT4	6860	broad.mit.edu	37	chr18	40857290	40857290	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctgaagggaaaactgcCtggctggattcacttgcctg	8	10	14	9	0	1	1	1	1	0	0	1	3	1	3	2	4	4	2	2	4	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:40857290C>A	uc002law.2	-	1	326	c.-43G>T	c.(-45--41)CAGGC>CATGC		SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Translation_Start_Site|SYT4_uc010dnh.2_RNA	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV							cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						GGAAAACTGCCTGGCTGGATT	0.552													13	58					2.27111e-07	2.58201e-07	1	0	A	40857290	A	A	40857290	1	1	58	1	0	0	0	0	0	0	0	0	15542	696	24	4		4	SYT4	18	40857290	Translation_Start_Site	SNP	C	TCGA-CN-5360-01A-01D-1434-08	11008822	40857290	37219958	480	11865											
SLC14A1	6563	broad.mit.edu	37	chr18	43329784	43329784	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggcccttctgtttggccacGctattgttcctcatcatgac	5	15	8	13	1	3	1	2	1	1	0	4	1	4	1	3	2	0	3	3	2	1	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:43329784G>A	uc010xcn.1	+	11	1357	c.1038G>A	c.(1036-1038)ACG>ACA	p.T346T	SLC14A1_uc010dnk.2_Silent_p.T402T|SLC14A1_uc002lbf.3_Silent_p.T346T|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Silent_p.T241T|SLC14A1_uc002lbh.3_Silent_p.T238T|SLC14A1_uc002lbi.3_Silent_p.T214T|SLC14A1_uc002lbj.3_Silent_p.T402T|SLC14A1_uc002lbk.3_Silent_p.T346T	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	346	Helical; (Potential).					integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						GTTTGGCCACGCTATTGTTCC	0.478													48	132					0	0	0	0	A	43329784	A	A	43329784	2	1	58	1	0	0	0	0	0	0	0	1	14461	1074	38	1		1	SLC14A1	18	43329784	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2472494	43329784	34747464	481	11866											
TXNL1	9352	broad.mit.edu	37	chr18	54293689	54293689	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcaaacatggcccacacCtgttagaaaaggaaaattaa	17	8	6	10	0	1	1	1	0	0	1	2	2	2	2	3	2	1	1	3	2	7	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:54293689C>A	uc002lgg.2	-	2	348	c.99_splice	c.e2-1	p.G33_splice	TXNL1_uc010xdz.1_Splice_Site|TXNL1_uc002lgh.2_Splice_Site|TXNL1_uc002lgi.2_Splice_Site_p.G33_splice|TXNL1_uc002lgj.1_Splice_Site_p.G33_splice	NM_004786	NP_004777	O43396	TXNL1_HUMAN	thioredoxin-like 1						cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		TGGCCCACACCTGTTAGAAAA	0.363													40	120					1.60099e-16	2.19813e-16	1	0	A	54293689	A	A	54293689	5	1	58	1	0	0	0	0	0	0	1	0	16872	695	24	4	799	4	TXNL1	18	54293689	Splice_Site	SNP	C	TCGA-CN-5360-01A-01D-1434-08	10963905	54293689	23783559	482	11867											
CPLX4	339302	broad.mit.edu	37	chr18	56985537	56985537	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catgtactcacttctcctcaAtcatttgcttttgatactcc	8	17	3	13	0	4	1	3	1	1	0	6	1	5	1	2	0	3	2	2	0	3	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:56985537A>G	uc002lhy.2	-	1	345	c.158T>C	c.(157-159)ATT>ACT	p.I53T		NM_181654	NP_857637	Q7Z7G2	CPLX4_HUMAN	complexin 4 precursor	53					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			ovary(1)	1		Colorectal(73;0.175)				CTTCTCCTCAATCATTTGCTT	0.408													56	148					0	0	0	0	G	56985537	G	G	56985537	3	3	58	1	0	0	0	0	1	0	0	0	3822	101	4	5	336	5	CPLX4	18	56985537	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	2691848	56985537	21091711	483	11868											
VPS4B	9525	broad.mit.edu	37	chr18	61066522	61066522	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggtatatttgtagctccCagaaccaaaattccatcatt	13	12	6	10	0	1	1	1	0	0	1	3	1	3	1	3	1	2	3	3	1	6	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:61066522C>T	uc002lix.2	-	8	1085	c.825G>A	c.(823-825)CTG>CTA	p.L275L	VPS4B_uc010dpx.2_Silent_p.L275L|VPS4B_uc010dpy.2_Silent_p.L157L|VPS4B_uc010dpz.1_Silent_p.L157L	NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B	275					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1						TTGTAGCTCCCAGAACCAAAA	0.348													43	100					0	0	0	0	T	61066522	T	T	61066522	2	4	58	1	0	0	0	0	0	0	0	1	17281	581	21	4		4	VPS4B	18	61066522	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	4080985	61066522	17010726	484	11869											
RTTN	25914	broad.mit.edu	37	chr18	67860629	67860629	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttcctggggaaggattctggGaatgatgagtacctcttgct	8	13	13	7	0	2	2	0	2	2	0	3	5	3	5	2	4	2	2	2	4	3	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:67860629G>A	uc002lkp.2	-	8	970	c.902C>T	c.(901-903)TCC>TTC	p.S301F	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_5'UTR|RTTN_uc002lkq.1_Missense_Mutation_p.S301F	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	301							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				AGGATTCTGGGAATGATGAGT	0.488													21	69					0	0	0	0	A	67860629	A	A	67860629	3	1	58	1	0	0	0	0	1	0	0	0	13802	1174	41	2	5946	2	RTTN	18	67860629	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6794107	67860629	10216619	485	11870											
C18orf62	284274	broad.mit.edu	37	chr18	73130849	73130849	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaccaacaatgtgaagaaaCgaatatggtgttcattttca	16	11	8	6	1	2	2	2	1	0	1	2	4	2	2	1	1	3	1	1	1	7	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:73130849C>T	uc002lma.1	-	2	223	c.152G>A	c.(151-153)CGT>CAT	p.R51H	C18orf62_uc010dqw.1_Intron|C18orf62_uc002lmb.1_RNA	NM_001037331	NP_001032408	Q3B7S5	CR062_HUMAN	hypothetical protein LOC284274	51	Helical; (Potential).					integral to membrane					0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		OV - Ovarian serous cystadenocarcinoma(15;6.21e-06)		TGTGAAGAAACGAATATGGTG	0.249													32	87					0	0	0	0	T	73130849	T	T	73130849	3	4	58	1	0	0	0	0	1	0	0	0	1915	536	19	1	161	1	C18orf62	18	73130849	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	5270220	73130849	4946399	486	11871											
GALR1	2587	broad.mit.edu	37	chr18	74962794	74962794	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccaggccaccgtgtacgCgctgcccacctgggtgctgg	4	8	13	16	3	0	0	0	0	0	0	1	0	1	0	5	3	3	3	5	3	1	2	rs140216881	byFrequency	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:74962794C>A	uc002lms.3	+	1	787	c.290C>A	c.(289-291)GCG>GAG	p.A97E		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	97	Extracellular (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		ACCGTGTACGCGCTGCCCACC	0.617													28	128					1.39806e-14	1.87417e-14	1	0	A	74962794	A	A	74962794	3	1	58	1	0	0	0	0	1	0	0	0	6262	768	27	3	292	3	GALR1	18	74962794	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1831945	74962794	3114454	487	11872											
NCLN	56926	broad.mit.edu	37	chr19	3207205	3207205	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctctccccagggacccagaGtttgtcttctacgaccagct	7	11	8	15	1	3	1	0	0	3	1	5	3	4	2	4	1	2	2	4	1	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:3207205G>A	uc002lxi.2	+	13	1663	c.1509G>A	c.(1507-1509)GAG>GAA	p.E503E	NCLN_uc002lxh.1_RNA|NCLN_uc002lxj.1_RNA|NCLN_uc002lxk.2_Silent_p.E147E	NM_020170	NP_064555	Q969V3	NCLN_HUMAN	nicalin precursor	503	Lumenal (Potential).				proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGACCCAGAGTTTGTCTTCT	0.512													38	114					0	0	0	0	A	3207205	A	A	3207205	2	1	58	1	0	0	0	0	0	0	0	1	10281	1020	36	4		4	NCLN	19	3207205	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08		3207205	55921778	488	11873											
GPR108	56927	broad.mit.edu	37	chr19	6734313	6734313	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctccatacttccgcaccTggaccctggggtgagggtgg	5	9	14	13	1	1	1	0	1	1	0	3	2	2	2	4	5	1	2	4	5	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:6734313T>C	uc002mfp.2	-	5	426	c.380A>G	c.(379-381)CAG>CGG	p.Q127R	GPR108_uc010duv.2_5'Flank|GPR108_uc002mfn.2_5'UTR|GPR108_uc002mfo.3_5'UTR|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	127						integral to membrane					0						CTTCCGCACCTGGACCCTGGG	0.637											OREG0025092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	38					0	0	0	0	C	6734313	C	C	6734313	3	2	58	1	0	0	0	0	1	0	0	0	6662	1580	55	5	1307	5	GPR108	19	6734313	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	3527108	6734313	52394670	489	11874											
INSR	3643	broad.mit.edu	37	chr19	7120658	7120658	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaagaagtggtgaagaccCcatccttcagggactccggt	11	7	12	11	1	1	4	1	1	0	3	3	5	3	5	4	3	0	0	4	3	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:7120658C>A	uc002mgd.1	-	20	3741	c.3632G>T	c.(3631-3633)GGG>GTG	p.G1211V	INSR_uc002mge.1_Missense_Mutation_p.G1199V	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1211	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGTGAAGACCCCATCCTTCAG	0.552													14	51					0.00244969	0.00254693	1	0	A	7120658	A	A	7120658	3	1	58	1	0	0	0	0	1	0	0	0	7812	623	22	4	528	4	INSR	19	7120658	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	386345	7120658	52008325	490	11875											
ARHGEF18	23370	broad.mit.edu	37	chr19	7529551	7529551	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagtgacagtgacattcctgGgagctctgaggaatcgccgc	9	8	13	11	2	1	3	0	3	1	0	3	5	2	5	2	2	1	1	2	2	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:7529551G>A	uc002mgi.2	+	13	2568	c.2315G>A	c.(2314-2316)GGG>GAG	p.G772E	ARHGEF18_uc010xjm.1_Missense_Mutation_p.G614E|ARHGEF18_uc002mgh.2_Missense_Mutation_p.G614E|ARHGEF18_uc002mgj.1_Missense_Mutation_p.G415E	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	772					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				GACATTCCTGGGAGCTCTGAG	0.557													16	32					0	0	0	0	A	7529551	A	A	7529551	3	1	58	1	0	0	0	0	1	0	0	0	901	1232	43	4	2365	4	ARHGEF18	19	7529551	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	408893	7529551	51599432	491	11876											
MUC16	94025	broad.mit.edu	37	chr19	9085606	9085606	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctgaggacagtgcctcaGataaactagtacttggccaa	12	8	11	10	0	1	2	1	1	0	1	1	3	1	3	3	3	3	1	3	3	5	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:9085606G>A	uc002mkp.2	-	1	6413	c.6209C>T	c.(6208-6210)TCT>TTT	p.S2070F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2070	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGTGCCTCAGATAAACTAGT	0.473													67	167					0	0	0	0	A	9085606	A	A	9085606	3	1	58	1	0	0	0	0	1	0	0	0	10026	942	33	2	37650	2	MUC16	19	9085606	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1556055	9085606	50043377	492	11877											
MUC16	94025	broad.mit.edu	37	chr19	9088915	9088915	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgggactagtctctggcCaagttgtgctttggggtgca	6	13	14	8	0	2	0	0	0	2	0	3	1	2	1	1	4	2	3	1	4	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:9088915C>T	uc002mkp.2	-	1	3104	c.2900G>A	c.(2899-2901)TGG>TAG	p.W967*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	967	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTCTCTGGCCAAGTTGTGCT	0.468													61	235					0	0	0	0	T	9088915	T	T	9088915	4	4	58	1	0	0	0	0	0	1	0	0	10026	595	21	4	40959	4	MUC16	19	9088915	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3309	9088915	50040068	493	11878											
RDH8	50700	broad.mit.edu	37	chr19	10129427	10129427	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaataatgctggaatgggcCtggtggggcccctggagggg	7	8	19	7	0	0	1	0	1	0	0	0	3	0	3	3	8	1	1	3	8	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:10129427C>A	uc002mmr.2	+	3	532	c.283C>A	c.(283-285)CTG>ATG	p.L95M		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	95	Helical; (Potential).				estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	TGGAATGGGCCTGGTGGGGCC	0.517													42	245					6.4308e-24	9.79726e-24	1	0	A	10129427	A	A	10129427	3	1	58	1	0	0	0	0	1	0	0	0	13261	680	24	4	293	4	RDH8	19	10129427	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1040512	10129427	48999556	494	11879											
TYK2	7297	broad.mit.edu	37	chr19	10464800	10464800	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaatctcctgcttccagccCgagcggtgctgggggccgca	5	8	13	15	3	2	0	1	0	1	0	4	1	3	0	4	3	4	3	4	3	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:10464800C>A	uc002moc.3	-	20	3204	c.2826G>T	c.(2824-2826)TCG>TCT	p.S942S	TYK2_uc010dxe.2_Silent_p.S757S	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	942	Protein kinase 2.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GCTTCCAGCCCGAGCGGTGCT	0.627													34	128					1.22384e-17	1.71136e-17	1	0	A	10464800	A	A	10464800	2	1	58	1	0	0	0	0	0	0	0	1	16878	639	23	3		3	TYK2	19	10464800	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	335373	10464800	48664183	495	11880											
ZNF440	126070	broad.mit.edu	37	chr19	11942379	11942380	+	Missense_Mutation	DNP	GG	TC	TC																															tgaacatcagaggtgacattGgacacaaggcatatgagtat																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:11942379_11942380GG>TC	uc002msp.1	+	4	544_545	c.388_389GG>TC	c.(388-390)GGA>TCA	p.G130S		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGTGACATTGGACACAAGGCA	0.406													21	221					0	0	0	0	TC	11942380	TC	TC	11942379	3	4	58	1	0	0	0	0	1	0	0	0	17980	1349	47	4	402	4	ZNF440	19	11942379	Missense_Mutation	DNP	GG	TCGA-CN-5360-01A-01D-1434-08	1477579	11942379	47186604	496	11881											
ZNF443	10224	broad.mit.edu	37	chr19	12542085	12542085	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttctctccagtgtgagttcTttcatgtattagacaagaac	10	16	7	8	0	3	3	1	1	2	2	5	3	4	3	1	0	1	2	1	0	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:12542085T>A	uc002mtu.2	-	4	1099	c.901A>T	c.(901-903)AGA>TGA	p.R301*		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	301	C2H2-type 6.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						GTGTGAGTTCTTTCATGTATT	0.408													68	220					0	0	0	0	A	12542085	A	A	12542085	4	1	58	1	0	0	0	0	0	1	0	0	17983	1617	56	5	1118	5	ZNF443	19	12542085	Nonsense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	599706	12542085	46586898	497	11882											
CYP4F8	11283	broad.mit.edu	37	chr19	15739139	15739139	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcccagttgcccttcctGaccatgtgcctgaaggagag	7	9	12	13	0	0	3	0	2	0	1	1	4	1	3	5	2	2	1	5	2	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:15739139G>T	uc002nbi.2	+	12	1207	c.1143G>T	c.(1141-1143)CTG>CTT	p.L381L	CYP4F8_uc010xoj.1_Silent_p.L193L	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	381					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TGCCCTTCCTGACCATGTGCC	0.617													33	120					6.05902e-23	9.14898e-23	1	0	T	15739139	T	T	15739139	2	4	58	1	0	0	0	0	0	0	0	1	4208	1277	45	2		2	CYP4F8	19	15739139	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3197054	15739139	43389844	498	11883											
CPAMD8	27151	broad.mit.edu	37	chr19	17015051	17015051	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcctgagtggaggagaaGcccccaagtgcatttcgctg	8	8	13	12	2	0	2	0	1	0	1	2	4	0	3	3	2	2	2	3	2	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:17015051G>T	uc002nfb.2	-	32	4409	c.4377C>A	c.(4375-4377)GGC>GGA	p.G1459G	CPAMD8_uc002nfd.1_5'Flank	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1412						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TGGAGGAGAAGCCCCCAAGTG	0.652													6	18					5.9392e-07	6.69635e-07	1	0	T	17015051	T	T	17015051	2	4	58	1	0	0	0	0	0	0	0	1	3810	958	34	4		4	CPAMD8	19	17015051	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1275912	17015051	42113932	499	11884											
ANKLE1	126549	broad.mit.edu	37	chr19	17394535	17394535	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgactgccactgcctgtGggagcaccagacatccattg	8	10	10	13	0	1	2	0	1	1	1	2	3	2	3	4	1	3	1	4	1	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:17394535G>A	uc002nga.2	+	5	1238	c.962G>A	c.(961-963)TGG>TAG	p.W321*	ANKLE1_uc010xpm.1_RNA|ANKLE1_uc010eao.1_Nonsense_Mutation_p.W343*|ANKLE1_uc010xpn.1_Nonsense_Mutation_p.W375*|ANKLE1_uc002nfy.2_Nonsense_Mutation_p.W310*|ANKLE1_uc002nfz.2_Nonsense_Mutation_p.W27*	NM_152363	NP_689576	Q8NAG6	ANKL1_HUMAN	ankyrin repeat domain 41	321						nuclear envelope					0						CACTGCCTGTGGGAGCACCAG	0.612													30	123					0	0	0	0	A	17394535	A	A	17394535	4	1	58	1	0	0	0	0	0	1	0	0	632	1357	47	4	980	4	ANKLE1	19	17394535	Nonsense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	379484	17394535	41734448	500	11885											
UNC13A	23025	broad.mit.edu	37	chr19	17756536	17756536	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtccgcacctcaatgatcGtctgccccaggaaatcgtca	9	8	9	15	4	3	1	2	1	1	0	6	2	4	2	4	1	1	1	4	1	2	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:17756536G>A	uc002nhd.2	-	19	2567	c.2567C>T	c.(2566-2568)ACG>ATG	p.T856M		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	768	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						CTCAATGATCGTCTGCCCCAG	0.592													4	36					0	0	0	0	A	17756536	A	A	17756536	3	1	58	1	0	0	0	0	1	0	0	0	17052	1145	40	1	2908	1	UNC13A	19	17756536	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	362001	17756536	41372447	501	11886											
JAK3	3718	broad.mit.edu	37	chr19	17949121	17949121	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatgtcatctgactcagcTggtattgggattggggctga	9	12	14	6	0	3	2	2	2	1	0	3	4	3	3	0	4	1	3	0	4	2	3	rs140690573		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:17949121T>A	uc002nhn.3	-	11	1620	c.1520A>T	c.(1519-1521)CAG>CTG	p.Q507L	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.Q507L|JAK3_uc010xpx.1_3'UTR	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	507					B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CTGACTCAGCTGGTATTGGGA	0.547		2	Mis		acute megakaryocytic leukemia|								94	205					0	0	0	0	A	17949121	A	A	17949121	3	1	58	1	0	0	0	0	1	0	0	0	7978	1580	55	5	1910	5	JAK3	19	17949121	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	192585	17949121	41179862	502	11887											
SLC5A5	6528	broad.mit.edu	37	chr19	17994720	17994720	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtggccttgggcgccaCgctgtacccacccagcgagc	5	6	15	15	3	0	0	0	0	0	0	0	1	0	0	4	3	3	2	4	3	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:17994720C>T	uc002nhr.3	+	12	1738	c.1391C>T	c.(1390-1392)ACG>ATG	p.T464M		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	464	Helical; (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TTGGGCGCCACGCTGTACCCA	0.721													5	2					0	0	0	0	T	17994720	T	T	17994720	3	4	58	1	0	0	0	0	1	0	0	0	14732	536	19	1	1437	1	SLC5A5	19	17994720	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	45599	17994720	41134263	503	11888											
IL12RB1	3594	broad.mit.edu	37	chr19	18182953	18182953	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggcaggaatgtgccacgtCtggttcaggccaggaccaaa	10	7	13	11	2	2	0	1	0	1	0	3	2	2	2	3	5	1	2	3	5	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:18182953C>A	uc002nhw.1	-	9	1054	c.990G>T	c.(988-990)CAG>CAT	p.Q330H	IL12RB1_uc010xqb.1_Missense_Mutation_p.Q330H|IL12RB1_uc002nhx.1_Missense_Mutation_p.Q370H|IL12RB1_uc002nhy.2_Missense_Mutation_p.Q330H	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	330	Extracellular (Potential).|Fibronectin type-III 3.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						TGTGCCACGTCTGGTTCAGGC	0.622													6	32					0.00116845	0.00122042	1	0	A	18182953	A	A	18182953	3	1	58	1	0	0	0	0	1	0	0	0	7665	912	32	2	1163	2	IL12RB1	19	18182953	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	188233	18182953	40946030	504	11889											
ZNF208	7757	broad.mit.edu	37	chr19	22155424	22155424	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacattcttcacatttgtaGggtttctcatcagtatgaat	10	16	6	9	0	4	1	3	1	2	0	5	1	4	1	1	1	0	3	1	1	3	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:22155424G>T	uc002nqp.2	-	5	2261	c.2112C>A	c.(2110-2112)CCC>CCA	p.P704P	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CACATTTGTAGGGTTTCTCAT	0.363													29	89					9.80776e-20	1.43021e-19	1	0	T	22155424	T	T	22155424	2	4	58	1	0	0	0	0	0	0	0	1	17833	987	35	4		4	ZNF208	19	22155424	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3972471	22155424	36973559	505	11890											
ZNF676	163223	broad.mit.edu	37	chr19	22363057	22363057	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttagtaaggattgagaacgTactaaagcctttgccacatt	13	13	8	7	1	0	1	0	1	0	1	0	3	0	2	2	1	4	2	2	1	6	8			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:22363057T>C	uc002nqs.1	-	3	1780	c.1462A>G	c.(1462-1464)ACG>GCG	p.T488A		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	488	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ATTGAGAACGTACTAAAGCCT	0.413													39	128					0	0	0	0	C	22363057	C	C	22363057	3	2	58	1	0	0	0	0	1	0	0	0	18150	1638	57	5	308	5	ZNF676	19	22363057	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	207633	22363057	36765926	506	11891											
ZNF676	163223	broad.mit.edu	37	chr19	22363257	22363257	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgccacattcttcacacttgTagggtttctctccagtatga	8	15	7	11	0	3	1	1	1	2	0	5	1	4	1	2	1	1	3	2	1	2	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:22363257T>G	uc002nqs.1	-	3	1580	c.1262A>C	c.(1261-1263)TAC>TCC	p.Y421S		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	421	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TTCACACTTGTAGGGTTTCTC	0.433													41	141					0	0	0	0	G	22363257	G	G	22363257	3	3	58	1	0	0	0	0	1	0	0	0	18150	1638	57	5	508	5	ZNF676	19	22363257	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	200	22363257	36765726	507	11892											
DPY19L3	147991	broad.mit.edu	37	chr19	32899172	32899172	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacatcatgatgtccatcCggcaaagaagagaaataaga	17	7	9	8	1	1	5	1	2	0	3	3	6	3	5	2	1	0	1	2	1	4	1	rs143875213		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:32899172C>T	uc002ntg.2	+	2	189	c.13C>T	c.(13-15)CGG>TGG	p.R5W	DPY19L3_uc002ntf.2_Missense_Mutation_p.R5W|DPY19L3_uc002nth.1_Missense_Mutation_p.R5W	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	5						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					GATGTCCATCCGGCAAAGAAG	0.423													15	56					0	0	0	0	T	32899172	T	T	32899172	3	4	58	1	0	0	0	0	1	0	0	0	4764	643	23	1	15	1	DPY19L3	19	32899172	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	10535915	32899172	26229811	508	11893											
MLL4	9757	broad.mit.edu	37	chr19	36217232	36217232	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gattacagcctctgccccagGtgcacccagctatatgagaa	11	8	9	13	0	1	1	0	1	1	1	1	3	1	1	4	1	5	2	4	1	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:36217232G>T	uc010eei.2	+	15	3981	c.3981G>T	c.(3979-3981)AGG>AGT	p.R1327S		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1327					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCTGCCCCAGGTGCACCCAGC	0.592													13	45					1.5842e-08	1.86974e-08	1	0	T	36217232	T	T	36217232	3	4	58	1	0	0	0	0	1	0	0	0	9676	1252	44	4	4035	4	MLL4	19	36217232	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3318060	36217232	22911751	509	11894											
ZNF382	84911	broad.mit.edu	37	chr19	37118348	37118348	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcagaaaactcacacaggcGagaaaccatatgaatgtaaa	20	6	7	8	1	2	3	2	1	0	2	2	4	2	3	1	1	2	1	1	1	7	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:37118348G>T	uc002oek.2	+	5	1662	c.1549G>T	c.(1549-1551)GAG>TAG	p.E517*	ZNF382_uc010efa.2_Nonsense_Mutation_p.E468*|ZNF382_uc010efb.2_Nonsense_Mutation_p.E516*|ZNF382_uc002oel.2_Nonsense_Mutation_p.E516*	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	517	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TCACACAGGCGAGAAACCATA	0.423													19	52					1.01871e-10	1.27997e-10	1	0	T	37118348	T	T	37118348	4	4	58	1	0	0	0	0	0	1	0	0	17940	1059	37	3	1559	3	ZNF382	19	37118348	Nonsense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	901116	37118348	22010635	510	11895											
LRFN1	57622	broad.mit.edu	37	chr19	39798856	39798856	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgagcacacgtggctgaccCgcgggagcgacctggagccc	7	3	16	15	5	0	1	0	1	0	0	0	5	0	3	3	3	3	2	3	3	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:39798856C>A	uc002okw.2	-	2	1733	c.1733G>T	c.(1732-1734)CGG>CTG	p.R578L		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	578	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GTGGCTGACCCGCGGGAGCGA	0.697													6	18					0.00116845	0.00122042	1	0	A	39798856	A	A	39798856	3	1	58	1	0	0	0	0	1	0	0	0	8987	652	23	3	586	3	LRFN1	19	39798856	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	2680508	39798856	19330127	511	11896											
TIMM50	92609	broad.mit.edu	37	chr19	39972552	39972552	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcgggagccgcgggagcacTaaggcgcaagggccacagca	11	2	16	12	4	0	0	0	0	0	0	1	2	0	2	2	4	3	3	2	4	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:39972552T>C	uc002olu.1	+	2	580	c.447T>C	c.(445-447)ACT>ACC	p.T149T	TIMM50_uc002olt.1_RNA	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50	46	Mitochondrial matrix (Potential).				mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			ovary(1)	1	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCGGGAGCACTAAGGCGCAAG	0.632													25	123					0	0	0	0	C	39972552	C	C	39972552	2	2	58	1	0	0	0	0	0	0	0	1	15979	1509	53	5		5	TIMM50	19	39972552	Silent	SNP	T	TCGA-CN-5360-01A-01D-1434-08	173696	39972552	19156431	512	11897											
CEACAM5	1048	broad.mit.edu	37	chr19	42213713	42213713	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttgtccacaatctgccccAgcatctttttggctacagct	8	13	6	14	0	2	0	0	0	2	0	3	0	3	0	3	1	4	3	3	1	2	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:42213713A>T	uc002ork.2	+	2	300	c.179A>T	c.(178-180)CAG>CTG	p.Q60L	CEACAM5_uc010ehz.1_Missense_Mutation_p.Q60L|CEACAM5_uc002orj.1_Missense_Mutation_p.Q60L|CEACAM5_uc002orl.2_Missense_Mutation_p.Q60L	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	60	Ig-like 1.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		AATCTGCCCCAGCATCTTTTT	0.507													53	142					0	0	0	0	T	42213713	T	T	42213713	3	4	58	1	0	0	0	0	1	0	0	0	3210	188	7	5	185	5	CEACAM5	19	42213713	Missense_Mutation	SNP	A	TCGA-CN-5360-01A-01D-1434-08	2241161	42213713	16915270	513	11898											
PSG7	5676	broad.mit.edu	37	chr19	43430641	43430641	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatgccaccatatcggtcccGtatttcacattgatagggtc	9	12	9	11	2	1	1	1	1	0	0	4	2	2	1	3	2	1	1	3	2	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:43430641G>C	uc002ovl.3	-	5	1039	c.937C>G	c.(937-939)CGG>GGG	p.R313G	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.R191G	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	313	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TATCGGTCCCGTATTTCACAT	0.522													6	242					0	0	0	0	C	43430641	C	C	43430641	3	2	58	1	0	0	0	0	1	0	0	0	12722	1144	40	3	334	3	PSG7	19	43430641	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1216928	43430641	15698342	514	11899											
CABP5	56344	broad.mit.edu	37	chr19	48543892	48543892	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttgctggccgagctcaaTcagttccatctccgtgggca	7	11	11	12	2	3	0	2	0	1	0	5	2	4	0	3	2	2	4	3	2	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:48543892T>C	uc002phu.1	-	3	333	c.208A>G	c.(208-210)ATT>GTT	p.I70V		NM_019855	NP_062829	Q9NP86	CABP5_HUMAN	calcium binding protein 5	70	EF-hand 2.				signal transduction	cytoplasm	calcium ion binding			skin(1)	1		all_cancers(25;1.86e-08)|all_lung(116;1.14e-06)|all_epithelial(76;1.16e-06)|Lung NSC(112;2.54e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;4.09e-05)|all cancers(93;0.000322)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.058)		CCGAGCTCAATCAGTTCCATC	0.527													18	91					0	0	0	0	C	48543892	C	C	48543892	3	2	58	1	0	0	0	0	1	0	0	0	2546	1435	50	5	329	5	CABP5	19	48543892	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	5113251	48543892	10585091	515	11900											
NOSIP	51070	broad.mit.edu	37	chr19	50063282	50063282	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcgaatgttctgggtccCatagcccgaggccgctgggg	6	8	15	12	3	1	0	0	0	1	0	3	2	2	0	3	4	1	2	3	4	2	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:50063282C>A	uc002pok.2	-	4	237	c.85G>T	c.(85-87)GGG>TGG	p.G29W	NOSIP_uc002pol.2_Missense_Mutation_p.G29W|NOSIP_uc010yay.1_RNA	NM_015953	NP_057037	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	29					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		TTCTGGGTCCCATAGCCCGAG	0.607													8	26					0.000442599	0.000468756	1	0	A	50063282	A	A	50063282	3	1	58	1	0	0	0	0	1	0	0	0	10599	594	21	4	848	4	NOSIP	19	50063282	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1519390	50063282	9065701	516	11901											
C19orf41	126123	broad.mit.edu	37	chr19	50666294	50666295	+	Frame_Shift_Del	DEL	GC	-	-																															tgcccatcagcacggccccgGcgcgcgcctgcagctgctcc																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:50666294_50666295delGC	uc002prp.1	-	1	244_245	c.157_158delGC	c.(157-159)GCCfs	p.A53fs		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	53	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		CACGGCCCCGGCGCGCGCCTGC	0.668													---	---	---								-	50666295	-	-	50666294	7	5	58	1	0	1	0	1	0	0	0	0	1933	1203	42	0	535	0	C19orf41	19	50666294	Frame_Shift_Del	DEL	GC	TCGA-CN-5360-01A-01D-1434-08	603012	50666294	8462689	517	11902											
SIGLEC10	89790	broad.mit.edu	37	chr19	51919978	51919978	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctttctggagaagtccacAtggcaggtgaggtcggtgtt	7	11	14	9	1	1	2	0	1	1	1	3	3	2	2	2	5	0	2	2	5	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:51919978A>G	uc002pwo.2	-	3	1264	c.648T>C	c.(646-648)CAT>CAC	p.H216H	SIGLEC10_uc002pwp.2_Silent_p.H158H|SIGLEC10_uc002pwq.2_Silent_p.H158H|SIGLEC10_uc002pwr.2_Silent_p.H216H|SIGLEC10_uc010ycy.1_Silent_p.H216H|SIGLEC10_uc010ycz.1_Silent_p.H168H|SIGLEC10_uc010eow.2_5'UTR|SIGLEC10_uc002pws.1_Silent_p.H142H	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	216	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AGAAGTCCACATGGCAGGTGA	0.632													12	41					0	0	0	0	G	51919978	G	G	51919978	2	3	58	1	0	0	0	0	0	0	0	1	14371	214	8	5		5	SIGLEC10	19	51919978	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	1253684	51919978	7209005	518	11903											
CEACAM18	729767	broad.mit.edu	37	chr19	51986470	51986470	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtcttgcctgggagcagatGggccgttaccgatgcactgt	7	10	14	10	2	1	1	0	0	1	1	1	3	1	2	3	2	4	3	3	2	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:51986470G>A	uc002pwv.1	+	5	1056	c.1056G>A	c.(1054-1056)ATG>ATA	p.M352I		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	352	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GGGAGCAGATGGGCCGTTACC	0.557													35	93					0	0	0	0	A	51986470	A	A	51986470	3	1	58	1	0	0	0	0	1	0	0	0	3204	1348	47	4	1074	4	CEACAM18	19	51986470	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	66492	51986470	7142513	519	11904											
ZNF610	162963	broad.mit.edu	37	chr19	52869373	52869373	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcagtcgcaattcacaccttGtagaacattggagaattcat	13	12	7	9	1	3	2	3	0	0	2	4	3	3	2	1	1	1	2	1	1	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:52869373G>T	uc002pyx.3	+	6	1148	c.742G>T	c.(742-744)GTA>TTA	p.V248L	ZNF610_uc002pyy.3_Missense_Mutation_p.V248L|ZNF610_uc002pyz.3_Missense_Mutation_p.V205L|ZNF610_uc002pza.2_Missense_Mutation_p.V248L	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	248	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		TTCACACCTTGTAGAACATTG	0.403													24	56					9.57634e-11	1.20768e-10	1	0	T	52869373	T	T	52869373	3	4	58	1	0	0	0	0	1	0	0	0	18103	1377	48	4	756	4	ZNF610	19	52869373	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	882903	52869373	6259610	520	11905											
ZNF677	342926	broad.mit.edu	37	chr19	53740380	53740380	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttttcaatgtgtattttctGgtgtctagtgaggtttgcaa	7	19	10	5	0	3	1	1	1	2	0	3	1	3	1	0	2	1	3	0	2	4	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:53740380G>A	uc002qbf.1	-	5	1785	c.1600C>T	c.(1600-1602)CAG>TAG	p.Q534*	ZNF677_uc002qbg.1_Nonsense_Mutation_p.Q534*	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	534	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		TGTATTTTCTGGTGTCTAGTG	0.318													23	87					0	0	0	0	A	53740380	A	A	53740380	4	1	58	1	0	0	0	0	0	1	0	0	18151	1357	47	4	158	4	ZNF677	19	53740380	Nonsense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	871007	53740380	5388603	521	11906											
PRKCG	5582	broad.mit.edu	37	chr19	54403966	54403966	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttccccgggacgacaacccGcaccttctgcgggaccccgg	6	5	11	19	5	1	0	0	0	1	0	2	3	2	2	6	3	2	1	6	3	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:54403966G>T	uc002qcq.1	+	14	1820	c.1538G>T	c.(1537-1539)CGC>CTC	p.R513L	PRKCG_uc010yeg.1_Missense_Mutation_p.R513L|PRKCG_uc010yeh.1_Missense_Mutation_p.R400L	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	513	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACGACAACCCGCACCTTCTGC	0.567													83	414					6.07207e-39	9.89254e-39	1	0	T	54403966	T	T	54403966	3	4	58	1	0	0	0	0	1	0	0	0	12574	1087	38	3	1592	3	PRKCG	19	54403966	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	663586	54403966	4725017	522	11907											
CACNG6	59285	broad.mit.edu	37	chr19	54502939	54502939	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgggcctggcagtcatggCcttggggtgcctctgtatca	4	11	15	11	0	3	0	2	0	1	0	3	0	3	0	3	5	1	3	3	5	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:54502939C>T	uc002qct.2	+	3	1048	c.458C>T	c.(457-459)GCC>GTC	p.A153V	CACNG6_uc002qcu.2_Intron|CACNG6_uc002qcv.2_Intron	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	153	Helical; (Potential).					voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		GCAGTCATGGCCTTGGGGTGC	0.562													118	347					0	0	0	0	T	54502939	T	T	54502939	3	4	58	1	0	0	0	0	1	0	0	0	2573	739	26	4	468	4	CACNG6	19	54502939	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	98973	54502939	4626044	523	11908											
C19orf51	352909	broad.mit.edu	37	chr19	55677772	55677772	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccgctgccggagccggcagGtgtggtcatcaccctgcgga	5	6	16	14	4	2	0	2	0	0	0	2	2	2	2	4	5	3	2	4	5	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:55677772G>T	uc002qji.1	-	2	44	c.10C>A	c.(10-12)CCT>ACT	p.P4T	C19orf51_uc002qjj.1_Missense_Mutation_p.P51T|C19orf51_uc002qjk.1_5'UTR|C19orf51_uc002qjl.1_Missense_Mutation_p.P51T			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	4											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GAGCCGGCAGGTGTGGTCATC	0.662											OREG0025679	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	46					2.21704e-12	2.87581e-12	1	0	T	55677772	T	T	55677772	3	4	58	1	0	0	0	0	1	0	0	0	1942	1261	44	4	1659	4	C19orf51	19	55677772	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1174833	55677772	3451211	524	11909											
SBK2	646643	broad.mit.edu	37	chr19	56042591	56042591	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgtgccgactcgatgccAatgccgtaggccgtcacgat	8	8	13	12	5	1	0	1	0	0	0	2	4	1	0	4	1	3	1	4	1	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:56042591A>G	uc010ygc.1	-	2	375	c.375T>C	c.(373-375)ATT>ATC	p.I125I		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	125	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0						ACTCGATGCCAATGCCGTAGG	0.652													10	33					0	0	0	0	G	56042591	G	G	56042591	2	3	58	1	0	0	0	0	0	0	0	1	13926	126	5	5		5	SBK2	19	56042591	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	364819	56042591	3086392	525	11910											
PEG3	5178	broad.mit.edu	37	chr19	57325540	57325540	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagcctctccatctggccCttcagcctctccgtttggct	3	13	8	17	1	4	0	1	0	3	0	6	0	4	0	5	2	3	3	5	2	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:57325540C>G	uc002qnu.2	-	7	4621	c.4270G>C	c.(4270-4272)GGG>CGG	p.G1424R	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G1395R|PEG3_uc002qnv.2_Missense_Mutation_p.G1424R|PEG3_uc002qnw.2_Missense_Mutation_p.G1300R|PEG3_uc002qnx.2_Missense_Mutation_p.G1298R|PEG3_uc010etr.2_Missense_Mutation_p.G1424R	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1424	Glu-rich.|4 X 5 AA repeat of P-X-G-E-A.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCATCTGGCCCTTCAGCCTCT	0.607													18	72					0	0	0	0	G	57325540	G	G	57325540	3	3	58	1	0	0	0	0	1	0	0	0	11774	681	24	4	500	4	PEG3	19	57325540	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1282949	57325540	1803443	526	11911											
USP29	57663	broad.mit.edu	37	chr19	57641829	57641829	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attccctggttctacccgttGaaccagacaagaatgccgac	11	9	8	13	2	1	3	0	1	1	2	2	4	2	3	4	1	3	2	4	1	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:57641829G>T	uc002qny.2	+	4	2142	c.1786G>T	c.(1786-1788)GAA>TAA	p.E596*		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	596					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCTACCCGTTGAACCAGACAA	0.488													19	48					5.3912e-06	5.91209e-06	1	0	T	57641829	T	T	57641829	4	4	58	1	0	0	0	0	0	1	0	0	17127	1291	45	2	1788	2	USP29	19	57641829	Nonsense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	316289	57641829	1487154	527	11912											
DUXA	503835	broad.mit.edu	37	chr19	57666725	57666725	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaagtaatctagatcttcGattttggaaccaaatctaag	15	12	8	6	1	3	2	0	0	3	2	4	5	3	3	1	1	1	1	1	1	6	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:57666725G>T	uc002qoa.1	-	5	499	c.454C>A	c.(454-456)CGA>AGA	p.R152R		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	152	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		CTAGATCTTCGATTTTGGAAC	0.383													20	47					1.56452e-12	2.03717e-12	1	0	T	57666725	T	T	57666725	2	4	58	1	0	0	0	0	0	0	0	1	4856	1066	37	3		3	DUXA	19	57666725	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	24896	57666725	1462258	528	11913											
ZNF460	10794	broad.mit.edu	37	chr19	57802666	57802666	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatggagataagccctttGtgtgcagtgaatgtggaagg	12	10	14	5	0	0	2	0	1	0	1	0	4	0	3	1	3	2	1	1	3	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:57802666G>A	uc002qog.2	+	3	1079	c.757G>A	c.(757-759)GTG>ATG	p.V253M	ZNF460_uc010ygv.1_Missense_Mutation_p.V212M	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	253	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TAAGCCCTTTGTGTGCAGTGA	0.542													30	84					0	0	0	0	A	57802666	A	A	57802666	3	1	58	1	0	0	0	0	1	0	0	0	17991	1377	48	4	767	4	ZNF460	19	57802666	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	135941	57802666	1326317	529	11914											
A1BG	1	broad.mit.edu	37	chr19	58862906	58862906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatctgggctggtgctgctcCtgggtaccagcagctctttc	4	12	13	12	0	2	0	0	0	2	0	4	1	3	0	2	3	5	6	2	3	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:58862906C>T	uc002qsd.3	-	5	823	c.761G>A	c.(760-762)AGG>AAG	p.R254K	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	254	Ig-like V-type 3.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		GGTGCTGCTCCTGGGTACCAG	0.627													11	50					0	0	0	0	T	58862906	T	T	58862906	3	4	58	1	0	0	0	0	1	0	0	0	1	681	24	4	742	4	A1BG	19	58862906	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1060240	58862906	266077	530	11915											
SNPH	9751	broad.mit.edu	37	chr20	1286353	1286353	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggccccagagcccatcacCcgtggacccaccccacagcg	9	2	10	20	2	1	1	1	0	0	1	1	3	1	2	7	2	2	0	7	2	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:1286353C>A	uc002wes.2	+	6	1376	c.1140C>A	c.(1138-1140)ACC>ACA	p.T380T	SNPH_uc002wet.2_Silent_p.T424T	NM_014723	NP_055538	O15079	SNPH_HUMAN	syntaphilin	380					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			ovary(2)	2						AGCCCATCACCCGTGGACCCA	0.672													13	52					0.00136819	0.00142686	1	0	A	1286353	A	A	1286353	2	1	58	1	0	0	0	0	0	0	0	1	14914	610	22	4		4	SNPH	20	1286353	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08		1286353	61739167	531	11916											
STK35	140901	broad.mit.edu	37	chr20	2097588	2097588	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actaagcaaggtctgtgctgGgctggcaccccgaggcaaag	10	6	14	11	1	1	0	0	0	1	0	1	1	1	0	2	4	2	5	2	4	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:2097588G>T	uc010gak.2	+	3	1169	c.1169G>T	c.(1168-1170)GGG>GTG	p.G390V	STK35_uc010zpu.1_Intron|STK35_uc002wfw.3_Missense_Mutation_p.G257V	NM_080836	NP_543026	Q8TDR2	STK35_HUMAN	serine/threonine kinase 35	390	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GTCTGTGCTGGGCTGGCACCC	0.542													13	78					2.32078e-09	2.8122e-09	1	0	T	2097588	T	T	2097588	3	4	58	1	0	0	0	0	1	0	0	0	15367	1232	43	4	1179	4	STK35	20	2097588	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	811235	2097588	60927932	532	11917											
SEL1L2	80343	broad.mit.edu	37	chr20	13868594	13868594	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgtttacaaaccaaaatCatctgggacatcatgtttcc	12	15	5	9	0	3	0	2	0	1	0	4	1	4	1	2	1	2	2	2	1	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:13868594C>A	uc010gcf.2	-	7	739	c.657G>T	c.(655-657)ATG>ATT	p.M219I	SEL1L2_uc002woq.3_Missense_Mutation_p.M80I|SEL1L2_uc010zrl.1_Missense_Mutation_p.M219I|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	219	Sel1-like 4.|Extracellular (Potential).					integral to membrane	binding			ovary(2)	2						AAACCAAAATCATCTGGGACA	0.368													17	119					2.94398e-08	3.45069e-08	1	0	A	13868594	A	A	13868594	3	1	58	1	0	0	0	0	1	0	0	0	14076	826	29	2	1465	2	SEL1L2	20	13868594	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	11771006	13868594	49156926	533	11918											
C20orf12	55184	broad.mit.edu	37	chr20	18377178	18377178	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaaccatcttcgtggacagTagcagagataagcttttaaa	15	10	8	8	1	1	1	0	0	1	1	2	3	1	2	1	1	3	3	1	1	5	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:18377178T>A	uc010zsa.1	-	15	1815	c.1606A>T	c.(1606-1608)ACT>TCT	p.T536S	C20orf12_uc010zrz.1_Missense_Mutation_p.T55S|C20orf12_uc002wqp.3_Missense_Mutation_p.T227S|C20orf12_uc002wqr.3_RNA|C20orf12_uc002wqs.3_Missense_Mutation_p.T403S|C20orf12_uc002wqq.3_Missense_Mutation_p.T517S	NM_001099407	NP_001092877	Q9NVP4	CT012_HUMAN	hypothetical protein LOC55184	344						intracellular	zinc ion binding			ovary(1)	1		Myeloproliferative disorder(85;0.0122)				TCGTGGACAGTAGCAGAGATA	0.383													58	90					0	0	0	0	A	18377178	A	A	18377178	3	1	58	1	0	0	0	0	1	0	0	0	2095	1638	57	5	737	5	C20orf12	20	18377178	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	4508584	18377178	44648342	534	11919											
GZF1	64412	broad.mit.edu	37	chr20	23346248	23346248	+	Frame_Shift_Del	DEL	G	-	-																															gcggcgagcggcaccgctgcGgccagtgcggcaagggcctg																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:23346248delG	uc010gdb.2	+	3	1402	c.1228delG	c.(1228-1230)GGCfs	p.G410fs	GZF1_uc002wsy.2_Frame_Shift_Del_p.G410fs|GZF1_uc010zsq.1_Intron|GZF1_uc010zsr.1_Intron|GZF1_uc002wsz.2_Frame_Shift_Del_p.G410fs	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	410	C2H2-type 4.				transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					GCACCGCTGCGGCCAGTGCGG	0.682													---	---	---								-	23346248	-	-	23346248	7	5	58	1	0	1	0	1	0	0	0	0	6953	1116	39	0	1230	0	GZF1	20	23346248	Frame_Shift_Del	DEL	G	TCGA-CN-5360-01A-01D-1434-08	4969070	23346248	39679272	535	11920											
VSX1	30813	broad.mit.edu	37	chr20	25060074	25060074	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgcctggccctatacctGtgccgccgcttcttcctctt	3	13	8	17	2	2	0	0	0	2	0	3	1	3	0	6	1	3	1	6	1	2	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:25060074G>A	uc002wuf.2	-	2	536	c.501C>T	c.(499-501)CAC>CAT	p.H167H	VSX1_uc002wue.2_RNA|VSX1_uc010gdd.1_Silent_p.H167H|VSX1_uc010gde.1_RNA|VSX1_uc010gdf.1_Silent_p.H167H|VSX1_uc002wug.1_Silent_p.H167H	NM_014588	NP_055403	Q9NZR4	VSX1_HUMAN	visual system homeobox 1 isoform a	167	Homeobox.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCCTATACCTGTGCCGCCGCT	0.557													13	29					0	0	0	0	A	25060074	A	A	25060074	2	1	58	1	0	0	0	0	0	0	0	1	17299	1368	48	4		4	VSX1	20	25060074	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1713826	25060074	37965446	536	11921											
DLGAP4	22839	broad.mit.edu	37	chr20	35154397	35154397	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcagctggtggagaccccCgagaagaggaaggtgagcat	11	5	17	8	1	0	4	0	1	0	3	0	7	0	5	2	5	2	3	2	5	2	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:35154397C>A	uc002xff.2	+	12	3174	c.2739C>A	c.(2737-2739)CCC>CCA	p.P913P	DLGAP4_uc010zvp.1_Silent_p.P913P|DLGAP4_uc002xfg.2_Silent_p.P209P|DLGAP4_uc002xfh.2_Silent_p.P377P|DLGAP4_uc002xfi.2_Silent_p.P222P|DLGAP4_uc002xfj.2_Silent_p.P209P|uc002xfk.3_Intron	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	916					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				TGGAGACCCCCGAGAAGAGGA	0.572													27	85					3.57733e-08	4.17151e-08	1	0	A	35154397	A	A	35154397	2	1	58	1	0	0	0	0	0	0	0	1	4584	639	23	3		3	DLGAP4	20	35154397	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	10094323	35154397	27871123	537	11922											
RBPJL	11317	broad.mit.edu	37	chr20	43942234	43942234	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgacagtgggctgccttcaCgctccacctgggtaatgaca	9	8	11	13	2	1	1	1	1	0	0	2	2	2	1	3	2	1	3	3	2	1	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:43942234C>A	uc002xns.2	+	7	818	c.746C>A	c.(745-747)ACG>AAG	p.T249K	RBPJL_uc002xnt.2_Missense_Mutation_p.T249K	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L	249					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GCTGCCTTCACGCTCCACCTG	0.378													11	19					2.80697e-09	3.3773e-09	1	0	A	43942234	A	A	43942234	3	1	58	1	0	0	0	0	1	0	0	0	13227	536	19	3	772	3	RBPJL	20	43942234	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	8787837	43942234	19083286	538	11923											
TPTE	7179	broad.mit.edu	37	chr21	10998291	10998291	+	RNA	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcattcacagcttcccgctCaggactagattctgattttc	9	14	6	12	1	4	2	3	1	1	1	6	3	5	3	1	1	1	2	1	1	1	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr21:10998291C>A	uc002yis.1	-	11		c.1962G>T						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCTTCCCGCTCAGGACTAGAT	0.383													30	213					4.22769e-11	5.3915e-11	1	0	A	10998291	A	A	10998291	1	1	58	0	1	0	0	0	0	0	0	0	16497	841	29	2		2	TPTE	21	10998291	RNA	SNP	C	TCGA-CN-5360-01A-01D-1434-08		10998291	37131604	539	11924											
POTEH	23784	broad.mit.edu	37	chr22	16287846	16287846	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaccaaatggcttcttcaCagaggaggcagccggcattg	11	7	13	10	1	2	2	1	0	1	2	2	4	2	3	2	4	1	3	2	4	1	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:16287846C>T	uc010gqp.2	-	1	92	c.40G>A	c.(40-42)GTG>ATG	p.V14M	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_Translation_Start_Site	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	14										skin(1)	1						GGCTTCTTCACAGAGGAGGCA	0.587													34	70					0	0	0	0	T	16287846	T	T	16287846	3	4	58	1	0	0	0	0	1	0	0	0	12322	478	17	4	1637	4	POTEH	22	16287846	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08		16287846	35016720	540	11925											
C22orf29	79680	broad.mit.edu	37	chr22	19839663	19839663	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caatccagggatccacaaggGgggtgtatgccaccccagga	11	5	13	12	0	0	0	0	0	0	0	2	2	2	2	5	5	1	1	5	5	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:19839663G>A	uc002zqg.2	-	2	721	c.122C>T	c.(121-123)CCC>CTC	p.P41L	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Missense_Mutation_p.P41L|C22orf29_uc002zqi.2_Missense_Mutation_p.P41L|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	41											0	Colorectal(54;0.0993)					ATCCACAAGGGGGGTGTATGC	0.617													48	125					0	0	0	0	A	19839663	A	A	19839663	3	1	58	1	0	0	0	0	1	0	0	0	2151	1232	43	4	976	4	C22orf29	22	19839663	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	3551817	19839663	31464903	541	11926											
MYO18B	84700	broad.mit.edu	37	chr22	26159210	26159210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caaaacagattcgggaagagGacaagagccctccaccatcc	15	4	9	13	1	0	3	0	0	0	3	3	5	2	5	4	2	2	0	4	2	4	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:26159210G>A	uc003abz.1	+	3	302	c.52G>A	c.(52-54)GAC>AAC	p.D18N	MYO18B_uc003aca.1_5'UTR|MYO18B_uc010guy.1_5'UTR|MYO18B_uc010guz.1_5'UTR|MYO18B_uc011aka.1_5'UTR	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	18						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TCGGGAAGAGGACAAGAGCCC	0.542													8	34					0	0	0	0	A	26159210	A	A	26159210	3	1	58	1	0	0	0	0	1	0	0	0	10119	1174	41	2	58	2	MYO18B	22	26159210	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6319547	26159210	25145356	542	11927											
NCF4	4689	broad.mit.edu	37	chr22	37273817	37273817	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcctcttcccctggaagctGcacatcacgcagaaggacaa	11	6	9	15	2	2	1	1	0	1	1	3	3	3	3	3	2	2	3	3	2	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:37273817G>C	uc003apy.3	+	10	1156	c.972G>C	c.(970-972)CTG>CTC	p.L324L	NCF4_uc003apz.3_3'UTR	NM_000631	NP_000622	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4 isoform 1	324					cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			ovary(1)	1						CCTGGAAGCTGCACATCACGC	0.607													7	17					0	0	0	0	C	37273817	C	C	37273817	2	2	58	1	0	0	0	0	0	0	0	1	10272	1306	46	4		4	NCF4	22	37273817	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	11114607	37273817	14030749	543	11928											
ENTHD1	150350	broad.mit.edu	37	chr22	40283742	40283742	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagtttttcacttgtctcCtgaacgccataagtaataca	13	13	5	10	1	2	1	1	1	1	0	3	1	2	1	2	0	2	2	2	0	5	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:40283742C>T	uc003ayg.2	-	2	262	c.11G>A	c.(10-12)AGG>AAG	p.R4K		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	4								p.R4K(1)		ovary(2)|skin(1)	3	Melanoma(58;0.0749)					CACTTGTCTCCTGAACGCCAT	0.393													19	62					0	0	0	0	T	40283742	T	T	40283742	3	4	58	1	0	0	0	0	1	0	0	0	5161	681	24	4	1836	4	ENTHD1	22	40283742	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	3009925	40283742	11020824	544	11929											
PKDREJ	10343	broad.mit.edu	37	chr22	46656831	46656831	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatttgttcagatcgaaagcGtttatctttttgctgatact	9	19	7	6	2	2	2	1	1	1	1	3	3	2	2	0	0	3	3	0	0	4	8	rs140368137	byFrequency	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:46656831G>T	uc003bhh.2	-	1	2389	c.2389C>A	c.(2389-2391)CGC>AGC	p.R797S		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	797	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GATCGAAAGCGTTTATCTTTT	0.398													32	112					1.08312e-15	1.47817e-15	1	0	T	46656831	T	T	46656831	3	4	58	1	0	0	0	0	1	0	0	0	12025	1145	40	3	4376	3	PKDREJ	22	46656831	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	6373089	46656831	4647735	545	11930											
SCO2	9997	broad.mit.edu	37	chr22	50962505	50962505	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagtcagccttgcagcgagcCcggcctctgtgatccagcag	8	7	12	14	2	2	1	1	1	1	0	3	2	3	1	4	1	5	2	4	1	1	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:50962505C>G	uc003bma.2	-	2	512	c.336G>C	c.(334-336)CGG>CGC	p.R112R	SCO2_uc003blz.3_Silent_p.R112R	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	112	Thioredoxin.				cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGCAGCGAGCCCGGCCTCTGT	0.632													10	38					0	0	0	0	G	50962505	G	G	50962505	2	3	58	1	0	0	0	0	0	0	0	1	13997	610	22	4		4	SCO2	22	50962505	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	4305674	50962505	342061	546	11931											
CPT1B	1375	broad.mit.edu	37	chr22	51009711	51009711	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctcataggtcaggcagaacTtacccctgtcctgggatata	10	10	9	12	0	2	1	2	0	0	1	3	2	3	2	4	3	2	1	4	3	5	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:51009711T>G	uc003bmk.3	-	14	1913	c.1751A>C	c.(1750-1752)AAG>ACG	p.K584T	CPT1B_uc003bml.2_Missense_Mutation_p.K584T|CPT1B_uc003bmm.2_Missense_Mutation_p.K584T|CPT1B_uc003bmo.2_Missense_Mutation_p.K584T|CPT1B_uc011asa.1_Missense_Mutation_p.K550T|CPT1B_uc003bmn.2_Missense_Mutation_p.K584T|CPT1B_uc011asb.1_Missense_Mutation_p.K503T|CHKB-CPT1B_uc003bmp.2_Missense_Mutation_p.K379T|uc003bmr.1_RNA	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	584	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		CAGGCAGAACTTACCCCTGTC	0.602													10	41					0	0	0	0	G	51009711	G	G	51009711	3	3	58	1	0	0	0	0	1	0	0	0	3847	1609	56	5	587	5	CPT1B	22	51009711	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	47206	51009711	294855	547	11932											
PIGA	5277	broad.mit.edu	37	chrX	15349561	15349561	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagcttgtttgtaagcacCgagctgacatcagcaaatcc	13	9	9	10	1	1	2	1	1	0	1	2	3	2	2	2	0	4	6	2	0	3	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:15349561C>G	uc004cwr.2	-	2	592	c.492G>C	c.(490-492)TCG>TCC	p.S164S	PIGA_uc004cwq.2_Intron|PIGA_uc010nev.2_Intron|PIGA_uc004cws.2_Intron|PIGA_uc011miq.1_Intron|PIGA_uc010new.1_Intron	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	164	Cytoplasmic (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)					TTGTAAGCACCGAGCTGACAT	0.443													24	24					0	0	0	0	G	15349561	G	G	15349561	2	3	58	1	0	0	0	0	0	0	0	1	11939	639	23	3		3	PIGA	23	15349561	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08		15349561	139920999	548	11933											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29414435	29414435	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtgaaaatgacactggActctgctataattccaagat	13	11	10	7	0	1	3	0	2	1	1	2	4	2	4	1	2	1	1	1	2	5	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:29414435A>T	uc004dby.2	+	4	931	c.423A>T	c.(421-423)GGA>GGT	p.G141G		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	141	Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						ATGACACTGGACTCTGCTATA	0.388													35	26					0	0	0	0	T	29414435	T	T	29414435	2	4	58	1	0	0	0	0	0	0	0	1	7700	262	10	5		5	IL1RAPL1	23	29414435	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	14064874	29414435	125856125	549	11934											
MAGEB3	4114	broad.mit.edu	37	chrX	30254123	30254123	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agacccaggatcaccagggtGctcagatcactgcaactaac	13	6	9	13	0	3	2	3	0	0	2	3	3	3	3	2	2	4	2	2	2	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:30254123G>T	uc004dca.1	+	5	819	c.82G>T	c.(82-84)GCT>TCT	p.A28S		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	28											0						TCACCAGGGTGCTCAGATCAC	0.517													16	23					1.15088e-07	1.31501e-07	1	0	T	30254123	T	T	30254123	3	4	58	1	0	0	0	0	1	0	0	0	9230	1319	46	4	84	4	MAGEB3	23	30254123	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	839688	30254123	125016437	550	11935											
MAGEB3	4114	broad.mit.edu	37	chrX	30254946	30254946	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caataaaactgtccccagtgCgttccagttctggtatgaag	11	11	9	10	1	1	1	0	1	1	0	3	1	3	1	3	1	2	3	3	1	5	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:30254946C>G	uc004dca.1	+	5	1642	c.905C>G	c.(904-906)GCG>GGG	p.A302G		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	302	MAGE.										0						GTCCCCAGTGCGTTCCAGTTC	0.502													22	18					0	0	0	0	G	30254946	G	G	30254946	3	3	58	1	0	0	0	0	1	0	0	0	9230	768	27	3	907	3	MAGEB3	23	30254946	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	823	30254946	125015614	551	11936											
MAGEB1	4112	broad.mit.edu	37	chrX	30269234	30269234	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcctctcctgggtgtgatCttcttaaagggcaactctgc	7	13	10	11	0	4	1	0	1	4	0	5	1	4	1	2	2	3	1	2	2	3	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:30269234C>A	uc004dcc.2	+	4	944	c.624C>A	c.(622-624)ATC>ATA	p.I208I	MAGEB1_uc004dcd.2_Silent_p.I208I|MAGEB1_uc004dce.2_Silent_p.I208I	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	208	MAGE.										0						TGGGTGTGATCTTCTTAAAGG	0.493													3	7					0.004672	0.00482065	1	0	A	30269234	A	A	30269234	2	1	58	1	0	0	0	0	0	0	0	1	9225	903	32	2		2	MAGEB1	23	30269234	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	14288	30269234	125001326	552	11937											
CXorf22	170063	broad.mit.edu	37	chrX	35989850	35989850	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aatcgattgttaaccaccagGggtatagcatctcaggagga	13	9	11	8	1	1	0	1	0	1	0	3	3	1	2	2	4	2	3	2	4	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:35989850G>T	uc004ddj.2	+	12	2177	c.2118G>T	c.(2116-2118)AGG>AGT	p.R706S	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	706										large_intestine(1)|lung(1)|ovary(1)	3						TAACCACCAGGGGTATAGCAT	0.418													16	32					0.00316338	0.00328393	1	0	T	35989850	T	T	35989850	3	4	58	1	0	0	0	0	1	0	0	0	4119	1223	43	4	2164	4	CXorf22	23	35989850	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5720616	35989850	119280710	553	11938											
ZNF630	57232	broad.mit.edu	37	chrX	47919477	47919477	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctgattatcaatatgccaGatttttaaaacagagtacaa	17	13	5	6	0	2	3	1	1	1	2	2	3	2	3	1	0	3	1	1	0	7	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:47919477G>C	uc004div.3	-	5	606	c.354C>G	c.(352-354)ATC>ATG	p.I118M	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Translation_Start_Site	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	118					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						CAATATGCCAGATTTTTAAAA	0.373													5	5					0	0	0	0	C	47919477	C	C	47919477	3	2	58	1	0	0	0	0	1	0	0	0	18121	932	33	2	1623	2	ZNF630	23	47919477	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	11929627	47919477	107351083	554	11939											
PJA1	64219	broad.mit.edu	37	chrX	68382107	68382107	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtcactcctcgcttcccgTttgtcttcagggtactttgg	3	16	10	12	2	3	0	2	0	1	0	6	0	5	0	2	3	1	3	2	3	1	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:68382107T>A	uc004dxh.2	-	2	1261	c.975A>T	c.(973-975)AAA>AAT	p.K325N	PJA1_uc011mpi.1_Missense_Mutation_p.K43N|PJA1_uc004dxg.2_Missense_Mutation_p.K137N|PJA1_uc004dxi.2_Missense_Mutation_p.K270N	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	325							zinc ion binding				0						TCGCTTCCCGTTTGTCTTCAG	0.552													17	18					0	0	0	0	A	68382107	A	A	68382107	3	1	58	1	0	0	0	0	1	0	0	0	12016	1722	60	5	960	5	PJA1	23	68382107	Missense_Mutation	SNP	T	TCGA-CN-5360-01A-01D-1434-08	20462630	68382107	86888453	555	11940											
MED12	9968	broad.mit.edu	37	chrX	70340889	70340889	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggctgaatactaccggccaGggcctgcaggaagtgggggc	8	6	17	10	1	0	1	0	1	0	0	0	2	0	2	3	6	3	2	3	6	4	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:70340889G>T	uc004dyy.2	+	5	821	c.622G>T	c.(622-624)GGG>TGG	p.G208W	MED12_uc011mpq.1_Missense_Mutation_p.G208W|MED12_uc004dyz.2_Missense_Mutation_p.G208W|MED12_uc004dza.2_Missense_Mutation_p.G55W	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	208					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CTACCGGCCAGGGCCTGCAGG	0.532													31	25					2.46105e-21	3.65136e-21	1	0	T	70340889	T	T	70340889	3	4	58	1	0	0	0	0	1	0	0	0	9481	1000	35	4	640	4	MED12	23	70340889	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1958782	70340889	84929671	556	11941											
KIAA2022	340533	broad.mit.edu	37	chrX	73963450	73963450	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattgtcctgaaaggattcAtatcgaattttcagggagca	13	12	9	7	1	2	1	2	1	0	0	4	4	3	3	1	2	1	1	1	2	3	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:73963450A>G	uc004eby.2	-	3	1559	c.942T>C	c.(940-942)TAT>TAC	p.Y314Y		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	314					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GAAAGGATTCATATCGAATTT	0.418													47	50					0	0	0	0	G	73963450	G	G	73963450	2	3	58	1	0	0	0	0	0	0	0	1	8308	224	8	5		5	KIAA2022	23	73963450	Silent	SNP	A	TCGA-CN-5360-01A-01D-1434-08	3622561	73963450	81307110	557	11942											
MAGEE2	139599	broad.mit.edu	37	chrX	75004401	75004401	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctatcctatcggtgatctgGaaaccccgtttgctgactaa	9	12	9	11	2	1	2	0	2	1	0	3	3	2	3	3	2	2	3	3	2	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:75004401G>T	uc004ecj.1	-	1	671	c.486C>A	c.(484-486)TTC>TTA	p.F162L		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	162	MAGE 1.									ovary(1)|skin(1)	2						CGGTGATCTGGAAACCCCGTT	0.527													10	12					5.16669e-11	6.56439e-11	1	0	T	75004401	T	T	75004401	3	4	58	1	0	0	0	0	1	0	0	0	9239	1165	41	2	1089	2	MAGEE2	23	75004401	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1040951	75004401	80266159	558	11943											
TBX22	50945	broad.mit.edu	37	chrX	79281194	79281194	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttcacccggactcaccctGctcgggagagacctggatgc	7	8	12	14	2	2	1	2	0	0	1	3	5	2	4	3	3	2	2	3	3	0	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:79281194G>T	uc010nmg.1	+	5	685	c.551G>T	c.(550-552)TGC>TTC	p.C184F	TBX22_uc004edi.1_Missense_Mutation_p.C64F|TBX22_uc004edj.1_Missense_Mutation_p.C184F	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	184	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						GACTCACCCTGCTCGGGAGAG	0.488													15	22					6.72482e-11	8.51228e-11	1	0	T	79281194	T	T	79281194	3	4	58	1	0	0	0	0	1	0	0	0	15724	1319	46	4	565	4	TBX22	23	79281194	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	4276793	79281194	75989366	559	11944											
APOOL	139322	broad.mit.edu	37	chrX	84258908	84258908	+	Translation_Start_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgaaaaccttggccgaaaGggttgtagacatggcggcca	11	8	13	9	2	1	2	0	1	1	1	1	3	1	2	3	4	1	2	3	4	4	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:84258908G>T	uc004eem.2	+	1	4	c.-10G>T	c.(-12--8)AAGGG>AATGG		APOOL_uc010nmp.2_RNA	NM_198450	NP_940852	Q6UXV4	APOOL_HUMAN	apolipoprotein O-like precursor							extracellular region					0						TTGGCCGAAAGGGTTGTAGAC	0.532													28	44					5.77227e-19	8.24092e-19	1	0	T	84258908	T	T	84258908	1	4	58	1	0	0	0	0	0	0	0	0	814	1015	35	4		4	APOOL	23	84258908	Translation_Start_Site	SNP	G	TCGA-CN-5360-01A-01D-1434-08	4977714	84258908	71011652	560	11945											
DACH2	117154	broad.mit.edu	37	chrX	86069720	86069720	+	Frame_Shift_Del	DEL	A	-	-																															aaaagcgcctgaagaaggagAaaaaaaccaagagaaaattg																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:86069720delA	uc004eew.2	+	10	1737	c.1567delA	c.(1567-1569)AAAfs	p.K523fs	DACH2_uc004eex.2_Frame_Shift_Del_p.K510fs|DACH2_uc010nmq.2_Frame_Shift_Del_p.K389fs|DACH2_uc011mra.1_Frame_Shift_Del_p.K356fs|DACH2_uc010nmr.2_Frame_Shift_Del_p.K304fs|DACH2_uc004eey.2_Frame_Shift_Del_p.K216fs|DACH2_uc004eez.2_Frame_Shift_Del_p.K206fs	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	523	Potential.|DACHbox-C.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						GAAGAAGGAGAAAAAAACCAA	0.428													---	---	---								-	86069720	-	-	86069720	7	5	58	1	0	1	0	1	0	0	0	0	4238	247	9	0	1605	0	DACH2	23	86069720	Frame_Shift_Del	DEL	A	TCGA-CN-5360-01A-01D-1434-08	1810812	86069720	69200840	561	11946											
PABPC5	140886	broad.mit.edu	37	chrX	90691137	90691137	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaattcccagaagagcgggcGgctgaggtcagaaccaggga	13	4	15	9	2	1	4	1	1	0	3	2	5	2	5	2	4	2	1	2	4	3	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:90691137G>T	uc004efg.2	+	2	1001	c.561G>T	c.(559-561)GCG>GCT	p.A187A	PABPC5_uc004eff.1_Silent_p.A23A	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	187						cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						AAGAGCGGGCGGCTGAGGTCA	0.493													21	12					8.34094e-07	9.3424e-07	1	0	T	90691137	T	T	90691137	2	4	58	1	0	0	0	0	0	0	0	1	11421	1103	39	3		3	PABPC5	23	90691137	Silent	SNP	G	TCGA-CN-5360-01A-01D-1434-08	4621417	90691137	64579423	562	11947											
PABPC5	140886	broad.mit.edu	37	chrX	90691163	90691163	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtcagaaccagggatagagCaactttcaccaatgttttcg	12	10	10	9	1	2	2	2	0	0	2	3	3	2	3	2	2	3	2	2	2	4	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:90691163C>A	uc004efg.2	+	2	1027	c.587C>A	c.(586-588)GCA>GAA	p.A196E	PABPC5_uc004eff.1_Missense_Mutation_p.A32E	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	196						cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						AGGGATAGAGCAACTTTCACC	0.458													20	22					1.56452e-12	2.03717e-12	1	0	A	90691163	A	A	90691163	3	1	58	1	0	0	0	0	1	0	0	0	11421	710	25	4	589	4	PABPC5	23	90691163	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	26	90691163	64579397	563	11948											
PCDH11X	27328	broad.mit.edu	37	chrX	91134249	91134249	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagtgacgaccttcgaggtaCctgtgtccgtacacaccaga	10	8	10	13	3	0	2	0	1	0	1	2	4	1	2	4	1	2	2	4	1	2	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:91134249C>T	uc004efk.1	+	2	3855	c.3010C>T	c.(3010-3012)CCT>TCT	p.P1004S	PCDH11X_uc004efl.1_Missense_Mutation_p.P1004S|PCDH11X_uc004efo.1_Missense_Mutation_p.P1004S|PCDH11X_uc010nmv.1_Missense_Mutation_p.P1004S|PCDH11X_uc004efm.1_Missense_Mutation_p.P1004S|PCDH11X_uc004efn.1_Missense_Mutation_p.P1004S|PCDH11X_uc004efh.1_Missense_Mutation_p.P1004S|PCDH11X_uc004efj.1_Missense_Mutation_p.P1004S	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1004	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTTCGAGGTACCTGTGTCCGT	0.423													44	72					0	0	0	0	T	91134249	T	T	91134249	3	4	58	1	0	0	0	0	1	0	0	0	11562	507	18	4	3016	4	PCDH11X	23	91134249	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	443086	91134249	64136311	564	11949											
TSPAN6	7105	broad.mit.edu	37	chrX	99890221	99890221	+	Frame_Shift_Del	DEL	A	-	-																															tggcagcgaccagttcgaccAaaaaaacgagagtcagaaac																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:99890221delA	uc004ega.1	-	3	408	c.305delT	c.(304-306)TTGfs	p.L102fs	TSPAN6_uc010nna.1_Frame_Shift_Del_p.L8fs	NM_003270	NP_003261	O43657	TSN6_HUMAN	transmembrane 4 superfamily member 6	102	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			ovary(1)	1						CAGTTCGACCAAAAAAACGAG	0.393													---	---	---								-	99890221	-	-	99890221	7	5	58	1	0	1	0	1	0	0	0	0	16718	131	5	0	452	0	TSPAN6	23	99890221	Frame_Shift_Del	DEL	A	TCGA-CN-5360-01A-01D-1434-08	8755972	99890221	55380339	565	11950											
USP26	83844	broad.mit.edu	37	chrX	132162179	132162179	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactgcttcaatgaatgcttCttttgacttagatatcccag	10	15	6	10	0	2	3	1	2	1	1	3	3	3	3	1	0	2	2	1	0	4	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:132162179C>G	uc010nrm.1	-	6	540	c.70G>C	c.(70-72)GAA>CAA	p.E24Q	USP26_uc011mvf.1_Missense_Mutation_p.E24Q	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	24					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					ATGAATGCTTCTTTTGACTTA	0.358													37	37					0	0	0	0	G	132162179	G	G	132162179	3	3	58	1	0	0	0	0	1	0	0	0	17125	922	32	2	2674	2	USP26	23	132162179	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	32271958	132162179	23108381	566	11951											
DDX26B	203522	broad.mit.edu	37	chrX	134680705	134680705	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgggatcaaaggttatttGccctggtgttgcgtttgcct	5	16	13	7	1	1	0	1	0	0	0	1	1	1	1	2	3	3	4	2	3	2	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:134680705G>T	uc004eyw.3	+	5	871	c.508G>T	c.(508-510)GCC>TCC	p.A170S		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	170	VWFA.										0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGTTATTTGCCCTGGTGTT	0.468													44	50					1.76056e-25	2.72486e-25	1	0	T	134680705	T	T	134680705	3	4	58	1	0	0	0	0	1	0	0	0	4370	1319	46	4	526	4	DDX26B	23	134680705	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	2518526	134680705	20589855	567	11952											
CDR1	1038	broad.mit.edu	37	chrX	139866414	139866414	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcaaattaatgtcttccaGcctacttgtgtcttccaaca	11	14	4	12	0	3	0	1	0	2	0	5	0	5	0	3	0	3	0	3	0	4	5			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:139866414G>T	uc004fbg.1	-	1	310	c.118C>A	c.(118-120)CTG>ATG	p.L40M	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	40	7.|23 X 6 AA approximate repeats.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				ATGTCTTCCAGCCTACTTGTG	0.438													50	52					4.44712e-29	7.0104e-29	1	0	T	139866414	T	T	139866414	3	4	58	1	0	0	0	0	1	0	0	0	3186	962	34	4	674	4	CDR1	23	139866414	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	5185709	139866414	15404146	568	11953											
MAGEC1	9947	broad.mit.edu	37	chrX	140994309	140994309	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggttttccccagtctcctctCcagattcctgggagcccctc	4	12	8	17	0	2	1	0	0	2	1	7	2	4	2	7	2	1	1	7	2	0	3			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:140994309C>A	uc004fbt.2	+	4	1405	c.1119C>A	c.(1117-1119)CTC>CTA	p.L373L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	373							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGTCTCCTCTCCAGATTCCTG	0.478										HNSCC(15;0.026)			90	104					7.49063e-41	1.22329e-40	1	0	A	140994309	A	A	140994309	2	1	58	1	0	0	0	0	0	0	0	1	9233	842	30	2		2	MAGEC1	23	140994309	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1127895	140994309	14276251	569	11954											
MAGEC1	9947	broad.mit.edu	37	chrX	140995492	140995492	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagtcctcagagtcctcctGaggggcctgctcagtctcct	6	10	11	14	0	3	3	2	1	1	2	7	3	6	3	5	2	1	1	5	2	0	0			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:140995492G>C	uc004fbt.2	+	4	2588	c.2302G>C	c.(2302-2304)GAG>CAG	p.E768Q	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	768							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTCCTCCTGAGGGGCCTGC	0.537										HNSCC(15;0.026)			98	122					0	0	0	0	C	140995492	C	C	140995492	3	2	58	1	0	0	0	0	1	0	0	0	9233	1291	45	2	2308	2	MAGEC1	23	140995492	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1183	140995492	14275068	570	11955											
MAGEC1	9947	broad.mit.edu	37	chrX	140995643	140995643	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagtcctgtgagctccttccCctcctccacttcatcgagtc	5	12	7	17	1	1	1	1	1	0	0	8	3	6	1	6	0	1	1	6	0	0	2			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:140995643C>A	uc004fbt.2	+	4	2739	c.2453C>A	c.(2452-2454)CCC>CAC	p.P818H	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	818							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGCTCCTTCCCCTCCTCCACT	0.552										HNSCC(15;0.026)			106	124					1.52339e-35	2.45836e-35	1	0	A	140995643	A	A	140995643	3	1	58	1	0	0	0	0	1	0	0	0	9233	623	22	4	2459	4	MAGEC1	23	140995643	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	151	140995643	14274917	571	11956											
SLITRK4	139065	broad.mit.edu	37	chrX	142716466	142716466	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgtaggtagtcaggggaaCtctgcagtttcgccttcagt	7	12	12	10	1	3	0	2	0	1	0	4	1	3	1	2	3	2	4	2	3	3	4			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:142716466C>A	uc004fbx.2	-	2	2835	c.2459G>T	c.(2458-2460)AGT>ATT	p.S820I	SLITRK4_uc004fby.2_Missense_Mutation_p.S820I	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	820	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GTCAGGGGAACTCTGCAGTTT	0.393													45	42					3.86361e-14	5.15905e-14	1	0	A	142716466	A	A	142716466	3	1	58	1	0	0	0	0	1	0	0	0	14809	565	20	4	58	4	SLITRK4	23	142716466	Missense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1720823	142716466	12554094	572	11957											
SLITRK4	139065	broad.mit.edu	37	chrX	142717845	142717845	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtatatttttctcttggcaGttcacacttagtcccaaatc	9	17	5	10	0	2	0	1	0	1	0	5	0	3	0	1	1	0	3	1	1	4	7			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:142717845G>T	uc004fbx.2	-	2	1456	c.1080C>A	c.(1078-1080)AAC>AAA	p.N360K	SLITRK4_uc004fby.2_Missense_Mutation_p.N360K	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	360	Extracellular (Potential).|LRRNT.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCTTGGCAGTTCACACTTA	0.458													71	67					1.34568e-36	2.18192e-36	1	0	T	142717845	T	T	142717845	3	4	58	1	0	0	0	0	1	0	0	0	14809	1020	36	4	1437	4	SLITRK4	23	142717845	Missense_Mutation	SNP	G	TCGA-CN-5360-01A-01D-1434-08	1379	142717845	12552715	573	11958											
SPANXN1	494118	broad.mit.edu	37	chrX	144337280	144337280	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaacagtattagcgttttgCtacaggaaagctaagaaaat	16	11	8	6	1	1	1	1	0	0	1	1	2	1	2	0	1	5	4	0	1	8	6			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:144337280C>A	uc004fcb.2	+	2	165	c.165C>A	c.(163-165)TGC>TGA	p.C55*		NM_001009614	NP_001009614	Q5VSR9	SPXN1_HUMAN	SPANX-N1 protein	55											0	Acute lymphoblastic leukemia(192;6.56e-05)					TAGCGTTTTGCTACAGGAAAG	0.433													39	32					1.42033e-22	2.1305e-22	1	0	A	144337280	A	A	144337280	4	1	58	1	0	0	0	0	0	1	0	0	15056	805	28	4	171	4	SPANXN1	23	144337280	Nonsense_Mutation	SNP	C	TCGA-CN-5360-01A-01D-1434-08	1619435	144337280	10933280	574	11959											
PLXNB3	5365	broad.mit.edu	37	chrX	153034499	153034499	+	Frame_Shift_Del	DEL	G	-	-																															acctgctgctggacagcagtGgcagtcacctctatgtcctg																										TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:153034499delG	uc004fii.2	+	5	1537	c.1363delG	c.(1363-1365)GGCfs	p.G455fs	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Frame_Shift_Del_p.G137fs|PLXNB3_uc010nuk.2_Frame_Shift_Del_p.G478fs|PLXNB3_uc011mzd.1_Frame_Shift_Del_p.G94fs	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	455	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GGACAGCAGTGGCAGTCACCT	0.642													---	---	---								-	153034499	-	-	153034499	7	5	58	1	0	1	0	1	0	0	0	0	12180	1348	47	0	1495	0	PLXNB3	23	153034499	Frame_Shift_Del	DEL	G	TCGA-CN-5360-01A-01D-1434-08	8697219	153034499	2236061	575	11960											
L1CAM	3897	broad.mit.edu	37	chrX	153134316	153134316	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgaacactgggcacaggCgctccgaaggccttgcacag	10	5	12	14	2	0	1	0	1	0	0	1	2	1	1	2	3	2	3	2	3	2	1			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:153134316C>A	uc004fjb.2	-	11	1467	c.1359G>T	c.(1357-1359)GCG>GCT	p.A453A	L1CAM_uc004fjc.2_Silent_p.A453A|L1CAM_uc010nuo.2_Silent_p.A448A|L1CAM_uc004fjd.1_Silent_p.A267A	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	453	Extracellular (Potential).|Ig-like C2-type 5.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGGCACAGGCGCTCCGAAGG	0.632													46	48					2.31418e-15	3.13312e-15	1	0	A	153134316	A	A	153134316	2	1	58	1	0	0	0	0	0	0	0	1	8628	755	27	3		3	L1CAM	23	153134316	Silent	SNP	C	TCGA-CN-5360-01A-01D-1434-08	99817	153134316	2136244	576	11961											
PIK3CD	5293	broad.mit.edu	37	chr1	9787005	9787005	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaacagaggaggaggcactGaagcacttccgagtgaagtt	15	6	13	7	1	0	3	0	2	0	1	1	6	1	5	1	3	2	3	1	3	4	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:9787005G>A	uc001aqb.3	+	24	3244	c.3036G>A	c.(3034-3036)CTG>CTA	p.L1012L	PIK3CD_uc010oaf.1_Silent_p.L1011L|PIK3CD_uc001aqe.3_Silent_p.L1036L	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	1012	PI3K/PI4K.				phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		AGGAGGCACTGAAGCACTTCC	0.557													13	31					0	0	0	0	A	9787005	A	A	9787005	2	1	59	1	0	0	0	0	0	0	0	1	11970	1277	45	2		2	PIK3CD	1	9787005	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08		9787005	239463616	1	11962											
ZNF684	127396	broad.mit.edu	37	chr1	40995229	40995230	+	5'Flank	DEL	AG	-	-																															gaggggacgggaggggaggcAgagagagagagatgtgttta																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:40995229_40995230delAG	uc001cft.1	+							NM_152373	NP_689586	Q5T5D7	ZN684_HUMAN	zinc finger protein 684						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			gaggggaggCAGAGAGAGAGAG	0.198													---	---	---								-	40995230	-	-	40995229	6	5	59	0	1	1	0	1	0	0	0	0	18158	203	7	0		0	ZNF684	1	40995229	5'Flank	DEL	AG	TCGA-CN-5361-01A-01D-1434-08	31208224	40995229	208255392	2	11963											
C8A	731	broad.mit.edu	37	chr1	57349161	57349161	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttttttcaggccctggCagatactggaatctcctcag	7	16	8	10	0	3	1	2	0	1	1	4	2	3	2	2	3	1	1	2	3	2	6	rs139740733		TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:57349161C>T	uc001cyo.2	+	6	794	c.662C>T	c.(661-663)GCA>GTA	p.A221V		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	221	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						CAGGCCCTGGCAGATACTGGA	0.338													11	104					0	0	0	0	T	57349161	T	T	57349161	3	4	59	1	0	0	0	0	1	0	0	0	2427	710	25	4	684	4	C8A	1	57349161	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	16353932	57349161	191901460	3	11964											
ROR1	4919	broad.mit.edu	37	chr1	64515514	64515514	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccaggagccccggaggctCtcctttcggtccaccatcta	6	9	10	16	2	2	0	0	0	2	0	6	2	4	2	6	4	1	1	6	4	1	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:64515514C>T	uc001dbj.2	+	3	714	c.315C>T	c.(313-315)CTC>CTT	p.L105L	ROR1_uc001dbi.3_Silent_p.L105L	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	105	Ig-like C2-type.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						CCCGGAGGCTCTCCTTTCGGT	0.572													55	181					0	0	0	0	T	64515514	T	T	64515514	2	4	59	1	0	0	0	0	0	0	0	1	13591	900	32	2		2	ROR1	1	64515514	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	7166353	64515514	184735107	4	11965											
GIPC2	54810	broad.mit.edu	37	chr1	78591604	78591604	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcaattgaaaagattgatGatgttcttgagttgtacatg	13	14	11	3	0	1	5	0	4	1	1	1	5	1	5	0	1	1	4	0	1	4	6			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:78591604G>A	uc001dik.2	+	5	944	c.754G>A	c.(754-756)GAT>AAT	p.D252N		NM_017655	NP_060125	Q8TF65	GIPC2_HUMAN	PDZ domain protein GIPC2	252						cytoplasm				ovary(1)	1						AAAGATTGATGATGTTCTTGA	0.294													14	50					0	0	0	0	A	78591604	A	A	78591604	3	1	59	1	0	0	0	0	1	0	0	0	6430	1290	45	2	772	2	GIPC2	1	78591604	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	14076090	78591604	170659017	5	11966											
ZNF644	84146	broad.mit.edu	37	chr1	91403466	91403473	+	Frame_Shift_Del	DEL	TTTTTCTT	-	-																															gcctttaagattttttcataTttttcttcattttgcatcat																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:91403466_91403473delTTTTTCTT	uc001dnw.2	-	4	3399_3406	c.3257_3264delAAGAAAAA	c.(3256-3264)GAAGAAAAAfs	p.E1086fs	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	1086_1088					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TTTTTTCATATTTTTCTTCATTTTGCAT	0.346													---	---	---								-	91403473	-	-	91403466	7	5	59	1	0	1	0	1	0	0	0	0	18127	1490	52	0	731	0	ZNF644	1	91403466	Frame_Shift_Del	DEL	TTTTTCTT	TCGA-CN-5361-01A-01D-1434-08	12811862	91403466	157847155	6	11967											
MTF2	22823	broad.mit.edu	37	chr1	93602313	93602313	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaagaagaggtcgtcttcCaagaagagcactccagactc	14	6	11	10	1	1	6	0	0	1	6	5	7	3	6	2	1	1	1	2	1	4	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:93602313C>A	uc009wdj.2	+	15	1803	c.1511C>A	c.(1510-1512)CCA>CAA	p.P504Q	MTF2_uc010oth.1_Missense_Mutation_p.P402Q|MTF2_uc009wdk.2_Missense_Mutation_p.P447Q|MTF2_uc001dpi.3_Missense_Mutation_p.P231Q|MTF2_uc010oti.1_Missense_Mutation_p.P402Q|MTF2_uc001dpj.3_Missense_Mutation_p.P402Q|MTF2_uc001dpl.3_Missense_Mutation_p.P402Q|MTF2_uc001dpm.3_Missense_Mutation_p.P173Q	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	504						nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		GGTCGTCTTCCAAGAAGAGCA	0.408													43	111					5.59293e-11	5.99242e-11	1	0	A	93602313	A	A	93602313	3	1	59	1	0	0	0	0	1	0	0	0	9976	594	21	4	1569	4	MTF2	1	93602313	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	2198847	93602313	155648308	7	11968											
CAPZA1	829	broad.mit.edu	37	chr1	113189888	113189888	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaggggaatttaatgaagtAttcaatggtgagtaaagatt	15	12	11	3	0	1	3	1	2	0	1	1	4	1	4	1	3	0	2	1	3	7	6			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:113189888A>C	uc001ecj.1	+	2	488	c.96A>C	c.(94-96)GTA>GTC	p.V32V		NM_006135	NP_006126	P52907	CAZA1_HUMAN	F-actin capping protein alpha-1 subunit	32					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex|WASH complex	actin binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTAATGAAGTATTCAATGGTG	0.338													56	87					0	0	0	0	C	113189888	C	C	113189888	2	2	59	1	0	0	0	0	0	0	0	1	2652	436	16	5		5	CAPZA1	1	113189888	Silent	SNP	A	TCGA-CN-5361-01A-01D-1434-08	19587575	113189888	136060733	8	11969											
CFHR5	81494	broad.mit.edu	37	chr1	196967390	196967390	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcttcagatacaggcactCagtctgtataaacgggaaat	14	10	8	9	1	4	1	2	0	2	1	4	2	4	2	0	2	2	2	0	2	5	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:196967390C>G	uc001gts.3	+	7	1231	c.1103C>G	c.(1102-1104)TCA>TGA	p.S368*		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	368	Sushi 6.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TACAGGCACTCAGTCTGTATA	0.323													14	49					0	0	0	0	G	196967390	G	G	196967390	4	3	59	1	0	0	0	0	0	1	0	0	3303	838	29	2	1129	2	CFHR5	1	196967390	Nonsense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	83777502	196967390	52283231	9	11970											
NAV1	89796	broad.mit.edu	37	chr1	201778369	201778369	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtggtggtgaggatgcccCcgcagcacatcatcaaaggg	9	6	16	10	1	2	1	2	1	0	0	2	2	2	2	2	5	2	2	2	5	1	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:201778369C>T	uc001gwu.2	+	20	4623	c.4276C>T	c.(4276-4278)CCG>TCG	p.P1426S	NAV1_uc001gwx.2_Missense_Mutation_p.P1035S	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1429					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						GAGGATGCCCCCGCAGCACAT	0.507													13	240					0	0	0	0	T	201778369	T	T	201778369	3	4	59	1	0	0	0	0	1	0	0	0	10236	623	22	4	4424	4	NAV1	1	201778369	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	4810979	201778369	47472252	10	11971											
AGT	183	broad.mit.edu	37	chr1	230846411	230846411	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtatgaaggtggggtctttGggcttcccggcattggcctt	4	13	16	8	1	1	1	0	1	1	0	2	1	2	1	2	7	0	3	2	7	2	5			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:230846411G>C	uc001hty.3	-	2	694	c.186C>G	c.(184-186)CCC>CCG	p.P62P	AGT_uc009xfe.2_Silent_p.P62P|AGT_uc009xff.2_Intron	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	62					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	TGGGGTCTTTGGGCTTCCCGG	0.567													8	103					0	0	0	0	C	230846411	C	C	230846411	2	2	59	1	0	0	0	0	0	0	0	1	399	1335	47	4		4	AGT	1	230846411	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	29068042	230846411	18404210	11	11972											
OR2W5	441932	broad.mit.edu	37	chr1	247654496	247654496	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcttctgatcggcctggaCtggagaaaattctctttgct	7	14	10	10	1	3	2	0	1	3	1	5	4	3	3	1	3	1	2	1	3	2	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr1:247654496C>A	uc001icz.1	+	1	67	c.67C>A	c.(67-69)CTG>ATG	p.L23M		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TCGGCCTGGACTGGAGAAAAT	0.488													22	81					7.41877e-09	7.89231e-09	1	0	A	247654496	A	A	247654496	3	1	59	1	0	0	0	0	1	0	0	0	11088	564	20	4	69	4	OR2W5	1	247654496	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	16808085	247654496	1596125	12	11973											
KIF3C	3797	broad.mit.edu	37	chr2	26203523	26203523	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcaatcactgggccctcagGgtacccaggcggggcggaca	8	5	14	14	2	3	0	3	0	0	0	3	1	3	1	2	6	1	1	2	6	2	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:26203523G>T	uc002rgu.2	-	1	1921	c.1264C>A	c.(1264-1266)CCT>ACT	p.P422T	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.P422T	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	422	Potential.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGCCCTCAGGGTACCCAGGC	0.662													56	175					2.53126e-37	2.94333e-37	1	0	T	26203523	T	T	26203523	3	4	59	1	0	0	0	0	1	0	0	0	8341	1232	43	4	1149	4	KIF3C	2	26203523	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08		26203523	216995850	13	11974											
HEATR5B	54497	broad.mit.edu	37	chr2	37215951	37215951	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ataaggagttgaaagggcacGattggaatgctggaagactg	14	8	15	4	1	0	2	0	1	0	1	0	6	0	5	0	4	1	3	0	4	4	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:37215951G>A	uc002rpp.1	-	35	5845	c.5749C>T	c.(5749-5751)CGT>TGT	p.R1917C	HEATR5B_uc002rpo.1_Missense_Mutation_p.R229C|HEATR5B_uc010ezy.1_Missense_Mutation_p.R412C	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1917							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				GAAAGGGCACGATTGGAATGC	0.358													33	75					0	0	0	0	A	37215951	A	A	37215951	3	1	59	1	0	0	0	0	1	0	0	0	7071	1058	37	1	474	1	HEATR5B	2	37215951	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	11012428	37215951	205983422	14	11975											
USP34	9736	broad.mit.edu	37	chr2	61597672	61597672	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaatatatgctccaccacAttgttgctaataagccagtc	13	11	5	12	0	0	0	0	0	0	0	2	0	1	0	4	0	3	3	4	0	5	6			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:61597672A>G	uc002sbe.2	-	9	1141	c.1119T>C	c.(1117-1119)AAT>AAC	p.N373N		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	373					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GCTCCACCACATTGTTGCTAA	0.303													29	86					0	0	0	0	G	61597672	G	G	61597672	2	3	59	1	0	0	0	0	0	0	0	1	17133	214	8	5		5	USP34	2	61597672	Silent	SNP	A	TCGA-CN-5361-01A-01D-1434-08	24381721	61597672	181601701	15	11976											
GFPT1	2673	broad.mit.edu	37	chr2	69601183	69601183	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtctctgaaggcctttgaTtagggtctccaggatttctc	7	14	10	10	0	3	2	0	2	3	0	6	3	3	3	2	3	0	0	2	3	2	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:69601183T>G	uc002sfh.2	-	2	249	c.70A>C	c.(70-72)ATC>CTC	p.I24L		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	24	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						AGGCCTTTGATTAGGGTCTCC	0.323													43	127					0	0	0	0	G	69601183	G	G	69601183	3	3	59	1	0	0	0	0	1	0	0	0	6382	1493	52	5	2047	5	GFPT1	2	69601183	Missense_Mutation	SNP	T	TCGA-CN-5361-01A-01D-1434-08	8003511	69601183	173598190	16	11977											
LRRTM1	347730	broad.mit.edu	37	chr2	80530937	80530937	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagagaccgagcagcaggAaatccattagcgagaatctt	15	6	11	9	2	1	2	0	0	1	2	2	7	2	3	2	1	3	2	2	1	3	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:80530937A>G	uc002sok.1	-	2	278	c.8T>C	c.(7-9)TTC>TCC	p.F3S	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	3						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GAGCAGCAGGAAATCCATTAG	0.562										HNSCC(69;0.2)			19	59					0	0	0	0	G	80530937	G	G	80530937	3	3	59	1	0	0	0	0	1	0	0	0	9089	246	9	5	1564	5	LRRTM1	2	80530937	Missense_Mutation	SNP	A	TCGA-CN-5361-01A-01D-1434-08	10929754	80530937	162668436	17	11978											
NCKAP5	344148	broad.mit.edu	37	chr2	133540069	133540069	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagcttggatgtactgcttgTttcaaaagtgcttggatgct	8	16	11	6	0	1	0	1	0	0	0	1	2	1	2	0	2	5	6	0	2	4	6			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:133540069T>C	uc002ttp.2	-	14	4689	c.4315A>G	c.(4315-4317)ACA>GCA	p.T1439A	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1439							protein binding				0						GTACTGCTTGTTTCAAAAGTG	0.572													25	63					0	0	0	0	C	133540069	C	C	133540069	3	2	59	1	0	0	0	0	1	0	0	0	10277	1725	60	5	1442	5	NCKAP5	2	133540069	Missense_Mutation	SNP	T	TCGA-CN-5361-01A-01D-1434-08	53009132	133540069	109659304	18	11979											
BAZ2B	29994	broad.mit.edu	37	chr2	160239306	160239306	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgttttcttagcatgaatgaTtctgagcctttaaatattat	11	19	6	5	0	2	3	0	3	2	0	2	3	2	3	1	0	2	2	1	0	6	8			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:160239306T>A	uc002uao.2	-	25	4121	c.3769A>T	c.(3769-3771)ATC>TTC	p.I1257F	BAZ2B_uc002uap.2_Missense_Mutation_p.I1221F	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1257					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						GCATGAATGATTCTGAGCCTT	0.398													29	85					0	0	0	0	A	160239306	A	A	160239306	3	1	59	1	0	0	0	0	1	0	0	0	1334	1493	52	5	2789	5	BAZ2B	2	160239306	Missense_Mutation	SNP	T	TCGA-CN-5361-01A-01D-1434-08	26699237	160239306	82960067	19	11980											
ITGB6	3694	broad.mit.edu	37	chr2	161030575	161030575	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgattcttcacaatttcattGaatctttcagcatcatttgt	10	19	4	8	0	6	2	4	2	2	0	6	2	6	2	0	0	1	1	0	0	2	6			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:161030575G>A	uc002ubh.2	-	5	685	c.669C>T	c.(667-669)TTC>TTT	p.F223F	ITGB6_uc010fow.1_RNA|ITGB6_uc010fou.2_Silent_p.F223F|ITGB6_uc010zcq.1_Silent_p.F181F|ITGB6_uc010fov.1_Silent_p.F223F	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	223	Extracellular (Potential).|VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						CAATTTCATTGAATCTTTCAG	0.353													17	52					0	0	0	0	A	161030575	A	A	161030575	2	1	59	1	0	0	0	0	0	0	0	1	7938	1281	45	2		2	ITGB6	2	161030575	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	791269	161030575	82168798	20	11981											
OSBPL6	114880	broad.mit.edu	37	chr2	179214036	179214036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tattgaatttcagactccccCtagccacctcactgaccctc	9	11	4	17	0	2	3	2	2	0	1	4	3	3	3	5	0	1	0	5	0	3	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:179214036C>T	uc002ulx.2	+	12	1451	c.1073C>T	c.(1072-1074)CCT>CTT	p.P358L	OSBPL6_uc002ulw.2_Missense_Mutation_p.P327L|OSBPL6_uc002uly.2_Missense_Mutation_p.P383L|OSBPL6_uc010zfe.1_Missense_Mutation_p.P327L|OSBPL6_uc002ulz.2_Missense_Mutation_p.P358L|OSBPL6_uc002uma.2_Missense_Mutation_p.P362L	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	358					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CAGACTCCCCCTAGCCACCTC	0.438													83	278					0	0	0	0	T	179214036	T	T	179214036	3	4	59	1	0	0	0	0	1	0	0	0	11335	681	24	4	1233	4	OSBPL6	2	179214036	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	18183461	179214036	63985337	21	11982											
TTN	7273	broad.mit.edu	37	chr2	179476145	179476145	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcagagatttcagatggctcGctgacaccaatagcattgac	12	10	9	10	1	2	4	2	2	0	2	3	5	2	4	1	1	1	3	1	1	2	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:179476145G>A	uc010zfg.1	-	218	43331	c.43107C>T	c.(43105-43107)AGC>AGT	p.S14369S	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.S8064S|TTN_uc010zfi.1_Silent_p.S7997S|TTN_uc010zfj.1_Silent_p.S7872S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15296							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGATGGCTCGCTGACACCAA	0.408													24	89					0	0	0	0	A	179476145	A	A	179476145	2	1	59	1	0	0	0	0	0	0	0	1	16803	1078	38	1		1	TTN	2	179476145	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	262109	179476145	63723228	22	11983											
COL6A3	1293	broad.mit.edu	37	chr2	238253355	238253355	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccccgtgggcagttgctctCagcaatggtcaggtcattca	7	10	11	13	1	4	0	4	0	1	0	5	0	4	0	2	3	2	4	2	3	1	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:238253355C>G	uc002vwl.2	-	36	7591	c.7306G>C	c.(7306-7308)GAG>CAG	p.E2436Q	COL6A3_uc002vwo.2_Missense_Mutation_p.E2230Q|COL6A3_uc010znj.1_Missense_Mutation_p.E1829Q|COL6A3_uc002vwj.2_5'Flank|COL6A3_uc002vwp.1_Missense_Mutation_p.E257Q	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2436	VWFA 11.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CAGTTGCTCTCAGCAATGGTC	0.557													41	160					0	0	0	0	G	238253355	G	G	238253355	3	3	59	1	0	0	0	0	1	0	0	0	3716	835	29	2	2263	2	COL6A3	2	238253355	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	58777210	238253355	4946018	23	11984											
COL6A3	1293	broad.mit.edu	37	chr2	238253401	238253401	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctcaagaccacatctcgcatCcggccgaaagtgtcttggtt	9	10	9	13	3	3	1	1	0	2	1	5	2	4	1	3	2	0	2	3	2	2	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr2:238253401C>G	uc002vwl.2	-	36	7545	c.7260G>C	c.(7258-7260)CGG>CGC	p.R2420R	COL6A3_uc002vwo.2_Silent_p.R2214R|COL6A3_uc010znj.1_Silent_p.R1813R|COL6A3_uc002vwj.2_5'Flank|COL6A3_uc002vwp.1_Silent_p.R241R	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2420	VWFA 11.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CATCTCGCATCCGGCCGAAAG	0.567													57	173					0	0	0	0	G	238253401	G	G	238253401	2	3	59	1	0	0	0	0	0	0	0	1	3716	842	30	2		2	COL6A3	2	238253401	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	46	238253401	4945972	24	11985											
ITPR1	3708	broad.mit.edu	37	chr3	4699938	4699938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctagatcccaccactctgcGtggaggtgacagccttgtcc	7	9	11	14	1	1	2	0	1	1	1	3	3	3	3	4	2	2	1	4	2	1	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr3:4699938G>A	uc003bqa.2	+	13	1475	c.1127G>A	c.(1126-1128)CGT>CAT	p.R376H	ITPR1_uc010hca.1_Missense_Mutation_p.R361H|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.R361H	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	376	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		ACCACTCTGCGTGGAGGTGAC	0.493													20	44					0	0	0	0	A	4699938	A	A	4699938	3	1	59	1	0	0	0	0	1	0	0	0	7959	1145	40	1	1169	1	ITPR1	3	4699938	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08		4699938	193322492	25	11986											
SCN11A	11280	broad.mit.edu	37	chr3	38888755	38888755	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtattgaagttctctaaaatCacagcaatgtacatgttgac	14	13	7	7	0	2	2	1	2	1	0	3	2	2	2	0	0	2	5	0	0	6	6			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr3:38888755C>A	uc011ays.1	-	26	5005	c.4806G>T	c.(4804-4806)GTG>GTT	p.V1602V		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1602	IV.|Helical; Name=S6 of repeat IV; (By similarity).				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCTCTAAAATCACAGCAATGT	0.413													4	123					0.00909568	0.00928131	1	0	A	38888755	A	A	38888755	2	1	59	1	0	0	0	0	0	0	0	1	13978	813	29	2		2	SCN11A	3	38888755	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	34188817	38888755	159133675	26	11987											
CSRNP1	64651	broad.mit.edu	37	chr3	39186502	39186502	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctaccttccactgcagcaTctccaacttctcctctttca	7	14	2	18	0	5	0	1	0	4	0	8	0	6	0	4	0	4	2	4	0	2	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr3:39186502T>A	uc003cjg.2	-	3	665	c.451A>T	c.(451-453)ATG>TTG	p.M151L	CSRNP1_uc003cjh.2_Missense_Mutation_p.M151L	NM_033027	NP_149016	Q96S65	CSRN1_HUMAN	AXIN1 up-regulated 1	151					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(4)|skin(1)	5						CACTGCAGCATCTCCAACTTC	0.617													27	39					0	0	0	0	A	39186502	A	A	39186502	3	1	59	1	0	0	0	0	1	0	0	0	3980	1435	50	5	1330	5	CSRNP1	3	39186502	Missense_Mutation	SNP	T	TCGA-CN-5361-01A-01D-1434-08	297747	39186502	158835928	27	11988											
COL7A1	1294	broad.mit.edu	37	chr3	48626135	48626135	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccgacaagtgcagtcactcGcactgagtagctgactccac	10	7	9	15	2	1	2	1	2	0	0	3	3	2	2	2	0	2	4	2	0	2	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr3:48626135G>A	uc003ctz.2	-	19	2528	c.2527C>T	c.(2527-2529)CGA>TGA	p.R843*		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	843	Nonhelical region (NC1).|Fibronectin type-III 7.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCAGTCACTCGCACTGAGTAG	0.617													29	54					0	0	0	0	A	48626135	A	A	48626135	4	1	59	1	0	0	0	0	0	1	0	0	3719	1095	38	1	6707	1	COL7A1	3	48626135	Nonsense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	9439633	48626135	149396295	28	11989											
HPS3	84343	broad.mit.edu	37	chr3	148889972	148889972	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcaacatttttcttgccatAtcttctctattgcagtcgaa	9	17	5	10	1	3	0	0	0	3	0	5	1	3	0	1	0	4	2	1	0	4	7			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr3:148889972A>G	uc003ewu.1	+	17	3118	c.2978A>G	c.(2977-2979)TAT>TGT	p.Y993C	CP_uc011bnr.1_Intron|HPS3_uc011bnq.1_Missense_Mutation_p.Y828C|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	993						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TTCTTGCCATATCTTCTCTAT	0.343									Hermansky-Pudlak_syndrome				44	57					0	0	0	0	G	148889972	G	G	148889972	3	3	59	1	0	0	0	0	1	0	0	0	7379	449	16	5	3044	5	HPS3	3	148889972	Missense_Mutation	SNP	A	TCGA-CN-5361-01A-01D-1434-08	100263837	148889972	49132458	29	11990											
EIF4G1	1981	broad.mit.edu	37	chr3	184039213	184039214	+	Missense_Mutation	DNP	GC	TT	TT																															cggggtctgagcctaatctcGcagtcctctctattcctggg																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr3:184039213_184039214GC>TT	uc003fnp.2	+	10	1039_1040	c.841_842GC>TT	c.(841-843)GCA>TTA	p.A281L	EIF4G1_uc003fno.1_Missense_Mutation_p.A222L|EIF4G1_uc010hxw.1_Missense_Mutation_p.A117L|EIF4G1_uc003fnt.2_5'UTR|EIF4G1_uc003fnq.2_Missense_Mutation_p.A194L|EIF4G1_uc003fnr.2_Missense_Mutation_p.A117L|EIF4G1_uc010hxx.2_Missense_Mutation_p.A288L|EIF4G1_uc003fns.2_Missense_Mutation_p.A241L|EIF4G1_uc010hxy.2_Missense_Mutation_p.A288L|EIF4G1_uc003fnv.3_Missense_Mutation_p.A281L|EIF4G1_uc003fnu.3_Missense_Mutation_p.A281L|EIF4G1_uc003fnw.2_Missense_Mutation_p.A288L|EIF4G1_uc003fnx.2_Missense_Mutation_p.A85L|EIF4G1_uc003fny.3_Missense_Mutation_p.A85L	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	281					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCCTAATCTCGCAGTCCTCTCT	0.55													24	116					0	0	0	0	TT	184039214	TT	TT	184039213	3	4	59	1	0	0	0	0	1	0	0	0	5060	1087	38	3	871	3	EIF4G1	3	184039213	Missense_Mutation	DNP	GC	TCGA-CN-5361-01A-01D-1434-08	35149241	184039213	13983217	30	11991											
TP63	8626	broad.mit.edu	37	chr3	189526081	189526081	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccacagtacacgaacctgggGctcctgaacagcatggacca	12	5	10	14	1	0	1	0	1	0	0	1	3	1	2	4	3	4	3	4	3	3	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr3:189526081G>T	uc003fry.2	+	4	434	c.345G>T	c.(343-345)GGG>GGT	p.G115G	TP63_uc003frx.2_Silent_p.G115G|TP63_uc003frz.2_Silent_p.G115G|TP63_uc010hzc.1_Silent_p.G115G|TP63_uc003fsa.2_Silent_p.G21G|TP63_uc003fsb.2_Silent_p.G21G|TP63_uc003fsc.2_Silent_p.G21G|TP63_uc003fsd.2_Silent_p.G21G|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_5'UTR	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	115					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CGAACCTGGGGCTCCTGAACA	0.567									Hay-Wells_syndrome	HNSCC(45;0.13)			143	152					6.50729e-104	7.80875e-104	1	0	T	189526081	T	T	189526081	2	4	59	1	0	0	0	0	0	0	0	1	16459	1190	42	4		4	TP63	3	189526081	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	5486868	189526081	8496349	31	11992											
C3orf34	84984	broad.mit.edu	37	chr3	196434583	196434583	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcttttggcaagctcctTgtcatctagtttgttcaggt	5	19	8	9	0	4	0	2	0	2	0	5	0	5	0	1	2	1	4	1	2	2	7			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr3:196434583T>A	uc011btw.1	-	3	725	c.343A>T	c.(343-345)AAG>TAG	p.K115*		NM_032898	NP_116287	Q96LK0	CEP19_HUMAN	hypothetical protein LOC84984	111						centriole|spindle pole					0	all_cancers(143;1.48e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00301)		GCAAGCTCCTTGTCATCTAGT	0.398													66	330					0	0	0	0	A	196434583	A	A	196434583	4	1	59	1	0	0	0	0	0	1	0	0	2234	1821	63	5	164	5	C3orf34	3	196434583	Nonsense_Mutation	SNP	T	TCGA-CN-5361-01A-01D-1434-08	6908502	196434583	1587847	32	11993											
WDFY3	23001	broad.mit.edu	37	chr4	85731060	85731060	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtcaaaagaatctgtggcTactttgtaaagataaataaa	17	12	7	5	0	2	2	1	0	1	2	2	2	2	2	0	1	1	2	0	1	10	5			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr4:85731060T>A	uc003hpd.2	-	14	2733	c.2325A>T	c.(2323-2325)GTA>GTT	p.V775V	WDFY3_uc003hpf.2_Silent_p.V775V	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	775						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AATCTGTGGCTACTTTGTAAA	0.363													29	75					0	0	0	0	A	85731060	A	A	85731060	2	1	59	1	0	0	0	0	0	0	0	1	17338	1509	53	5		5	WDFY3	4	85731060	Silent	SNP	T	TCGA-CN-5361-01A-01D-1434-08		85731060	105423216	33	11994											
MANBA	4126	broad.mit.edu	37	chr4	103578879	103578879	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acggccaggactgatatccaTattcagatgcaaatcgagct	13	9	9	10	2	1	2	1	1	0	1	3	4	2	3	2	2	2	2	2	2	3	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr4:103578879T>C	uc003hwg.2	-	12	1764	c.1664A>G	c.(1663-1665)TAT>TGT	p.Y555C	MANBA_uc011ces.1_Missense_Mutation_p.Y498C	NM_005908	NP_005899	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal precursor	555					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		CTGATATCCATATTCAGATGC	0.358													33	105					0	0	0	0	C	103578879	C	C	103578879	3	2	59	1	0	0	0	0	1	0	0	0	9272	1406	49	5	999	5	MANBA	4	103578879	Missense_Mutation	SNP	T	TCGA-CN-5361-01A-01D-1434-08	17847819	103578879	87575397	34	11995											
TACR3	6870	broad.mit.edu	37	chr4	104511031	104511031	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggactccattctggtcacGgtgtacatactgctttgccg	7	13	10	11	2	2	0	1	0	1	0	3	1	3	1	2	3	4	2	2	3	2	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr4:104511031G>A	uc003hxe.1	-	5	1349	c.1206C>T	c.(1204-1206)ACC>ACT	p.T402T		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	402	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TTCTGGTCACGGTGTACATAC	0.502													88	281					0	0	0	0	A	104511031	A	A	104511031	2	1	59	1	0	0	0	0	0	0	0	1	15573	1103	39	1		1	TACR3	4	104511031	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	932152	104511031	86643245	35	11996											
PDE5A	8654	broad.mit.edu	37	chr4	120528105	120528105	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agaaaattttgtgacataagGctgtgacatccaaatgacta	16	11	8	6	0	0	4	0	3	0	1	1	4	1	4	1	1	0	1	1	1	5	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr4:120528105G>T	uc003idh.2	-	2	655	c.500C>A	c.(499-501)GCC>GAC	p.A167D	PDE5A_uc003idf.2_Missense_Mutation_p.A125D|PDE5A_uc003idg.2_Missense_Mutation_p.A115D	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	167	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	GTGACATAAGGCTGTGACATC	0.428													49	110					6.61955e-31	7.57964e-31	1	0	T	120528105	T	T	120528105	3	4	59	1	0	0	0	0	1	0	0	0	11698	1203	42	4	2207	4	PDE5A	4	120528105	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	16017074	120528105	70626171	36	11997											
RXFP1	59350	broad.mit.edu	37	chr4	159560442	159560442	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gggattgaaatttcaaatatCcaacaaaggatgtttagacc	16	11	8	6	0	1	2	1	1	0	1	2	4	2	4	2	2	1	1	2	2	6	5			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr4:159560442C>G	uc003ipz.2	+	14	1156	c.1074C>G	c.(1072-1074)ATC>ATG	p.I358M	RXFP1_uc010iqj.1_Missense_Mutation_p.I187M|RXFP1_uc011cja.1_Missense_Mutation_p.I253M|RXFP1_uc010iqo.2_Missense_Mutation_p.I310M|RXFP1_uc011cjb.1_Missense_Mutation_p.I256M|RXFP1_uc010iqk.2_Missense_Mutation_p.I226M|RXFP1_uc011cjc.1_Missense_Mutation_p.I277M|RXFP1_uc011cjd.1_Missense_Mutation_p.I277M|RXFP1_uc010iql.2_Missense_Mutation_p.I202M|RXFP1_uc011cje.1_Missense_Mutation_p.I385M|RXFP1_uc010iqm.2_Missense_Mutation_p.I325M|RXFP1_uc011cjf.1_Missense_Mutation_p.I227M|RXFP1_uc010iqn.2_Missense_Mutation_p.I303M	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	358	Extracellular (Potential).|LRR 9.					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TTTCAAATATCCAACAAAGGA	0.274													14	75					0	0	0	0	G	159560442	G	G	159560442	3	3	59	1	0	0	0	0	1	0	0	0	13824	845	30	2	1128	2	RXFP1	4	159560442	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	39032337	159560442	31593834	37	11998											
RAPGEF2	9693	broad.mit.edu	37	chr4	160252611	160252611	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtagtattattgtgggtaaAtaatcacttcaatgactttg	12	16	9	4	0	2	1	2	1	0	0	2	1	2	1	0	2	0	3	0	2	7	8			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr4:160252611A>G	uc003iqg.3	+	8	1323	c.1013A>G	c.(1012-1014)AAT>AGT	p.N338S		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	338	N-terminal Ras-GEF.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TTGTGGGTAAATAATCACTTC	0.303													22	63					0	0	0	0	G	160252611	G	G	160252611	3	3	59	1	0	0	0	0	1	0	0	0	13109	101	4	5	1043	5	RAPGEF2	4	160252611	Missense_Mutation	SNP	A	TCGA-CN-5361-01A-01D-1434-08	692169	160252611	30901665	38	11999											
WWC2	80014	broad.mit.edu	37	chr4	184203868	184203868	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttttaccataggctaacaAtgctaagagaggcctctgat	12	12	9	8	0	1	2	0	1	1	1	1	3	1	2	2	2	3	3	2	2	5	5			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr4:184203868A>G	uc010irx.2	+	18	2874	c.2692A>G	c.(2692-2694)ATG>GTG	p.M898V	WWC2_uc003ivk.3_Missense_Mutation_p.M693V|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Missense_Mutation_p.M580V|WWC2_uc003ivn.3_Missense_Mutation_p.M413V|WWC2_uc010irz.2_Missense_Mutation_p.M239V|WWC2_uc003ivo.3_Missense_Mutation_p.M26V	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	898										ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		TAGGCTAACAATGCTAAGAGA	0.413													2	4					0	0	0	0	G	184203868	G	G	184203868	3	3	59	1	0	0	0	0	1	0	0	0	17480	101	4	5	2762	5	WWC2	4	184203868	Missense_Mutation	SNP	A	TCGA-CN-5361-01A-01D-1434-08	23951257	184203868	6950408	39	12000											
CTNND2	1501	broad.mit.edu	37	chr5	11384811	11384811	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcctctggagggtggccgtGgcatacagctcctgcgagtg	5	8	17	11	2	1	0	0	0	1	0	2	2	2	1	3	5	3	2	3	5	1	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr5:11384811G>C	uc003jfa.1	-	7	1288	c.1143C>G	c.(1141-1143)GCC>GCG	p.A381A	CTNND2_uc010itt.2_Silent_p.A290A|CTNND2_uc011cmy.1_Intron|CTNND2_uc011cmz.1_Intron|CTNND2_uc010itu.1_Intron|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	381					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GGGTGGCCGTGGCATACAGCT	0.697													10	30					0	0	0	0	C	11384811	C	C	11384811	2	2	59	1	0	0	0	0	0	0	0	1	4037	1335	47	4		4	CTNND2	5	11384811	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08		11384811	169530449	40	12001											
HCN1	348980	broad.mit.edu	37	chr5	45396672	45396672	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgacaaacatggcatagcaGgtggccccgacgatcatgct	11	6	11	13	3	1	0	1	0	0	0	1	3	1	0	3	3	3	3	3	3	2	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr5:45396672G>C	uc003jok.2	-	4	1177	c.1152C>G	c.(1150-1152)ACC>ACG	p.T384T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	384	Helical; Name=Segment S6; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TGGCATAGCAGGTGGCCCCGA	0.507													23	76					0	0	0	0	C	45396672	C	C	45396672	2	2	59	1	0	0	0	0	0	0	0	1	7035	987	35	4		4	HCN1	5	45396672	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	34011861	45396672	135518588	41	12002											
TTC37	9652	broad.mit.edu	37	chr5	94849321	94849322	+	Missense_Mutation	DNP	TA	AT	AT																															tgaagagatccatggtgtcaTaacttccaactgcctcagca																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr5:94849321_94849322TA>AT	uc003klb.2	-	27	3001_3002	c.2731_2732TA>AT	c.(2731-2733)TAT>ATT	p.Y911I		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	911							binding			ovary(3)|pancreas(1)	4						CATGGTGTCATAACTTCCAACT	0.332													28	59					0	0	0	0	AT	94849322	AT	AT	94849321	3	1	59	1	0	0	0	0	1	0	0	0	16773	1406	49	5	2030	5	TTC37	5	94849321	Missense_Mutation	DNP	TA	TCGA-CN-5361-01A-01D-1434-08	49452649	94849321	86065939	42	12003											
UIMC1	51720	broad.mit.edu	37	chr5	176396609	176396609	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggagacatgccttcagtGagcccagagtctgtggtttt	8	11	13	9	0	2	3	1	1	1	2	2	4	2	3	2	2	2	1	2	2	0	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr5:176396609G>T	uc011dfp.1	-	5	623	c.456C>A	c.(454-456)CTC>CTA	p.L152L	UIMC1_uc003mfc.1_Nonsense_Mutation_p.S28*|UIMC1_uc003mfd.1_Nonsense_Mutation_p.S28*|UIMC1_uc003mfg.1_Intron|UIMC1_uc003mfh.1_Silent_p.L152L|UIMC1_uc010jkj.1_Silent_p.L152L|UIMC1_uc003mff.1_Nonsense_Mutation_p.S28*	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	152	Necessary for interaction with NR6A1 N- terminus.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGCCTTCAGTGAGCCCAGAGT	0.517													23	22					1.36565e-18	1.51738e-18	1	0	T	176396609	T	T	176396609	2	4	59	1	0	0	0	0	0	0	0	1	17039	1277	45	2		2	UIMC1	5	176396609	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	81547288	176396609	4518651	43	12004											
OR2V2	285659	broad.mit.edu	37	chr5	180582306	180582306	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgggactcatggcttatGaccgctatgtggccattagc	7	12	12	10	1	1	1	1	1	0	0	1	2	1	2	2	3	2	3	2	3	3	3	rs150156274	byFrequency	TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr5:180582306G>T	uc011dhj.1	+	1	364	c.364G>T	c.(364-366)GAC>TAC	p.D122Y		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D122N(1)		ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATGGCTTATGACCGCTATGT	0.522													59	72					1.77205e-36	2.04467e-36	1	0	T	180582306	T	T	180582306	3	4	59	1	0	0	0	0	1	0	0	0	11085	1290	45	2	366	2	OR2V2	5	180582306	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	4185697	180582306	332954	44	12005											
OR2B6	26212	broad.mit.edu	37	chr6	27925495	27925495	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagtaactcagtgtggttGtctaccctgactctccagct	7	15	8	11	0	3	1	1	1	2	0	4	1	3	1	2	1	3	3	2	1	3	5			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr6:27925495G>A	uc011dkx.1	+	1	477	c.477G>A	c.(475-477)TTG>TTA	p.L159L		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CAGTGTGGTTGTCTACCCTGA	0.488													44	103					0	0	0	0	A	27925495	A	A	27925495	2	1	59	1	0	0	0	0	0	0	0	1	11045	1368	48	4		4	OR2B6	6	27925495	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08		27925495	143189572	45	12006											
PKHD1	5314	broad.mit.edu	37	chr6	51947979	51947979	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaaaaccccaacctaccatCaaaaatgactgtgatccacg	16	7	5	13	1	1	2	1	2	0	0	2	2	2	2	5	0	3	1	5	0	6	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr6:51947979C>T	uc003pah.1	-	3	403	c.127G>A	c.(127-129)GAT>AAT	p.D43N	PKHD1_uc003pai.2_Missense_Mutation_p.D43N	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	43	Extracellular (Potential).|IPT/TIG 1; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AACCTACCATCAAAAATGACT	0.398													13	117					0	0	0	0	T	51947979	T	T	51947979	3	4	59	1	0	0	0	0	1	0	0	0	12026	826	29	2	12396	2	PKHD1	6	51947979	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	24022484	51947979	119167088	46	12007											
ZNF451	26036	broad.mit.edu	37	chr6	56999545	56999545	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcttttgctgagtaggttCgatcactctccatgtgatcc	6	15	8	12	1	3	2	1	2	2	0	6	3	4	2	3	1	1	3	3	1	1	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr6:56999545C>T	uc003pdm.1	+	7	803	c.579C>T	c.(577-579)TTC>TTT	p.F193F	ZNF451_uc003pdl.2_Silent_p.F193F|ZNF451_uc003pdn.1_Silent_p.F193F|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Silent_p.F193F	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	193	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TGAGTAGGTTCGATCACTCTC	0.353													32	96					0	0	0	0	T	56999545	T	T	56999545	2	4	59	1	0	0	0	0	0	0	0	1	17989	883	31	1		1	ZNF451	6	56999545	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	5051566	56999545	114115522	47	12008											
LGSN	51557	broad.mit.edu	37	chr6	63990490	63990490	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaacatgtttttcttcctAtcgacatcccagagactatg	11	13	6	11	1	1	2	0	0	1	2	4	4	3	2	2	0	1	1	2	0	3	5			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr6:63990490A>G	uc003peh.2	-	4	1000	c.966T>C	c.(964-966)GAT>GAC	p.D322D	LGSN_uc003pei.2_Missense_Mutation_p.I182T	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	322					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	TTTTCTTCCTATCGACATCCC	0.438													33	81					0	0	0	0	G	63990490	G	G	63990490	2	3	59	1	0	0	0	0	0	0	0	1	8800	449	16	5		5	LGSN	6	63990490	Silent	SNP	A	TCGA-CN-5361-01A-01D-1434-08	6990945	63990490	107124577	48	12009											
CD109	135228	broad.mit.edu	37	chr6	74516767	74516767	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttacagcctatattgtaaCttctctcctgggatatagaa	12	14	6	9	0	1	1	0	0	1	1	3	2	2	2	2	1	3	1	2	1	7	8	rs141815508		TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr6:74516767C>G	uc003php.2	+	25	3586	c.3161C>G	c.(3160-3162)ACT>AGT	p.T1054S	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Missense_Mutation_p.T1054S|CD109_uc010kba.2_Missense_Mutation_p.T977S	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	1054						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						TATATTGTAACTTCTCTCCTG	0.363													16	51					0	0	0	0	G	74516767	G	G	74516767	3	3	59	1	0	0	0	0	1	0	0	0	2978	565	20	4	3259	4	CD109	6	74516767	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	10526277	74516767	96598300	49	12010											
MYO6	4646	broad.mit.edu	37	chr6	76527375	76527375	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attgaacccttgaatcagaaAggcaaggtgagtttctcaga	14	10	10	7	0	2	5	2	3	1	2	3	5	2	5	1	2	1	2	1	2	4	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr6:76527375A>G	uc003pih.1	+	2	390	c.111A>G	c.(109-111)AAA>AAG	p.K37K	MYO6_uc003pig.1_Silent_p.K37K|MYO6_uc003pii.1_Silent_p.K37K	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	37	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		TGAATCAGAAAGGCAAGGTGA	0.403													23	98					0	0	0	0	G	76527375	G	G	76527375	2	3	59	1	0	0	0	0	0	0	0	1	10134	69	3	5		5	MYO6	6	76527375	Silent	SNP	A	TCGA-CN-5361-01A-01D-1434-08	2010608	76527375	94587692	50	12011											
ZNF292	23036	broad.mit.edu	37	chr6	87969024	87969024	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttctgaaatgataaacattCaatttaatgacaaagttaat	18	15	4	4	0	2	3	1	3	1	0	2	3	2	3	0	0	1	1	0	0	7	6			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr6:87969024C>T	uc003plm.3	+	8	5718	c.5677C>T	c.(5677-5679)CAA>TAA	p.Q1893*		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1893					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GATAAACATTCAATTTAATGA	0.353													23	63					0	0	0	0	T	87969024	T	T	87969024	4	4	59	1	0	0	0	0	0	1	0	0	17893	827	29	2	5707	2	ZNF292	6	87969024	Nonsense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	11441649	87969024	83146043	51	12012											
MCHR2	84539	broad.mit.edu	37	chr6	100368869	100368869	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgatttccttctcagtcgCtcttctttggatttgaggca	5	18	9	9	1	3	2	1	2	3	0	6	3	4	3	1	2	0	3	1	2	0	6			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr6:100368869C>A	uc003pqh.1	-	6	1285	c.970G>T	c.(970-972)GCG>TCG	p.A324S	MCHR2_uc003pqi.1_Missense_Mutation_p.A324S	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	324	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		TTCTCAGTCGCTCTTCTTTGG	0.423													45	190					1.86633e-21	2.12083e-21	1	0	A	100368869	A	A	100368869	3	1	59	1	0	0	0	0	1	0	0	0	9436	797	28	4	56	4	MCHR2	6	100368869	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	12399845	100368869	70746198	52	12013											
TBPL1	9519	broad.mit.edu	37	chr6	134308158	134308158	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttacccatttgtgtttgaaAgcaggaaagaaattttataa	15	15	7	4	0	0	2	0	1	0	1	0	3	0	3	1	1	2	2	1	1	6	7			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr6:134308158A>G	uc010kgg.2	+	7	1101	c.541A>G	c.(541-543)AGC>GGC	p.S181G	TBPL1_uc003qel.2_Missense_Mutation_p.S181G	NM_004865	NP_004856	P62380	TBPL1_HUMAN	TBP-like 1	181					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	cytoplasm	DNA binding|protein binding|transcription coactivator activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00591)|OV - Ovarian serous cystadenocarcinoma(155;0.00848)		TGTGTTTGAAAGCAGGAAAGA	0.398													23	83					0	0	0	0	G	134308158	G	G	134308158	3	3	59	1	0	0	0	0	1	0	0	0	15711	72	3	5	563	5	TBPL1	6	134308158	Missense_Mutation	SNP	A	TCGA-CN-5361-01A-01D-1434-08	33939289	134308158	36806909	53	12014											
ESR1	2099	broad.mit.edu	37	chr6	152129446	152129446	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtgccctactacctggaGaacgagcccagcggctacac	10	5	11	15	2	0	1	0	0	0	1	0	3	0	1	3	3	7	1	3	3	4	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr6:152129446G>A	uc003qom.3	+	3	769	c.399G>A	c.(397-399)GAG>GAA	p.E133E	ESR1_uc010kin.2_Silent_p.E133E|ESR1_uc010kio.2_Silent_p.E133E|ESR1_uc010kip.2_Silent_p.E133E|ESR1_uc003qon.3_Silent_p.E133E|ESR1_uc003qoo.3_Silent_p.E133E|ESR1_uc010kiq.2_5'UTR|ESR1_uc010kir.2_Silent_p.E133E	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	133	Modulating; mediates interaction with MACROD1.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	ACTACCTGGAGAACGAGCCCA	0.532													3	6					0	0	0	0	A	152129446	A	A	152129446	2	1	59	1	0	0	0	0	0	0	0	1	5280	933	33	2		2	ESR1	6	152129446	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	17821288	152129446	18985621	54	12015											
OGDH	4967	broad.mit.edu	37	chr7	44715628	44715628	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcaggatcaatcgtgtcacCgacaggaacattaccttgtc	11	9	9	12	3	2	0	2	0	0	0	4	3	2	2	2	2	2	1	2	2	3	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr7:44715628C>A	uc003tln.2	+	9	1195	c.1086C>A	c.(1084-1086)ACC>ACA	p.T362T	OGDH_uc003tlm.2_Silent_p.T362T|OGDH_uc011kbx.1_Silent_p.T358T|OGDH_uc011kby.1_Silent_p.T212T|OGDH_uc003tlp.2_Silent_p.T373T|OGDH_uc011kbz.1_Silent_p.T157T|OGDH_uc003tlo.1_Silent_p.T195T	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	362					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	ATCGTGTCACCGACAGGAACA	0.552													165	135					2.19381e-74	2.61168e-74	1	0	A	44715628	A	A	44715628	2	1	59	1	0	0	0	0	0	0	0	1	10893	639	23	3		3	OGDH	7	44715628	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08		44715628	114423035	55	12016											
TNS3	64759	broad.mit.edu	37	chr7	47385791	47385791	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgtggcacatacctctttGacgtccgctggtgaggggaa	7	10	14	10	2	1	2	0	2	1	0	2	3	2	3	2	4	1	3	2	4	2	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr7:47385791G>C	uc003tnv.2	-	18	2812	c.2445C>G	c.(2443-2445)GTC>GTG	p.V815V	TNS3_uc003tnw.2_Silent_p.V815V	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	815						focal adhesion	protein binding			ovary(4)	4						ATACCTCTTTGACGTCCGCTG	0.592													26	101					0	0	0	0	C	47385791	C	C	47385791	2	2	59	1	0	0	0	0	0	0	0	1	16410	1277	45	2		2	TNS3	7	47385791	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	2670163	47385791	111752872	56	12017											
PNPLA8	50640	broad.mit.edu	37	chr7	108112931	108112935	+	Frame_Shift_Del	DEL	CTTGA	-	-																															tttctgcagagttgttttttCttgacttaatatttttgcaa																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr7:108112931_108112935delCTTGA	uc003vff.1	-	12	2666_2670	c.2259_2263delTCAAG	c.(2257-2265)AGTCAAGAAfs	p.S753fs	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Frame_Shift_Del_p.S753fs|PNPLA8_uc003vfi.1_Frame_Shift_Del_p.S653fs|PNPLA8_uc003vfj.1_Frame_Shift_Del_p.S753fs|PNPLA8_uc003vfk.1_Frame_Shift_Del_p.S653fs	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	753_755					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						GTTGTTTTTTCTTGACTTAATATTT	0.288													---	---	---								-	108112935	-	-	108112931	7	5	59	1	0	1	0	1	0	0	0	0	12226	922	32	0	89	0	PNPLA8	7	108112931	Frame_Shift_Del	DEL	CTTGA	TCGA-CN-5361-01A-01D-1434-08	60727140	108112931	51025732	57	12018											
C7orf68	29923	broad.mit.edu	37	chr7	128097493	128097493	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccaccaagggccttccagaCcatccatccagaagcatgtg	11	6	8	16	0	0	2	0	0	0	2	3	2	3	2	7	1	1	1	7	1	2	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr7:128097493C>G	uc003vne.3	+	2	433	c.171C>G	c.(169-171)GAC>GAG	p.D57E	C7orf68_uc010lli.2_Missense_Mutation_p.D57E|C7orf68_uc010llj.1_Intron	NM_013332	NP_037464	Q9Y5L2	HIG2_HUMAN	hypoxia-inducible protein 2	57					autocrine signaling|positive regulation of cell proliferation|response to stress	cell surface|extracellular space|integral to membrane|stored secretory granule	receptor binding				0						GCCTTCCAGACCATCCATCCA	0.542													22	78					0	0	0	0	G	128097493	G	G	128097493	3	3	59	1	0	0	0	0	1	0	0	0	2424	506	18	4	173	4	C7orf68	7	128097493	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	19984562	128097493	31041170	58	12019											
SMO	6608	broad.mit.edu	37	chr7	128852282	128852282	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaactcatggatgcagactCggacttctgagcctgcagag	11	8	12	10	1	2	4	1	1	1	3	3	6	2	6	1	2	4	2	1	2	1	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr7:128852282C>T	uc003vor.2	+	12	2634	c.2354C>T	c.(2353-2355)TCG>TTG	p.S785L	SMO_uc003vos.2_3'UTR	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	785	Cytoplasmic (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						GATGCAGACTCGGACTTCTGA	0.607			Mis		skin basal cell 								26	102					0	0	0	0	T	128852282	T	T	128852282	3	4	59	1	0	0	0	0	1	0	0	0	14864	893	31	1	2400	1	SMO	7	128852282	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	754789	128852282	30286381	59	12020											
PRSS1	5644	broad.mit.edu	37	chr7	142460802	142460802	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgtgcccagaagaacaaGcctggagtctacaccaaggt	12	6	12	11	0	1	2	0	0	1	2	1	3	1	3	3	3	4	1	3	3	5	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr7:142460802G>A	uc003wak.2	+	5	692	c.675G>A	c.(673-675)AAG>AAA	p.K225K	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Silent_p.K165K	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	225	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			AGAAGAACAAGCCTGGAGTCT	0.512									Hereditary_Pancreatitis				9	202					0	0	0	0	A	142460802	A	A	142460802	2	1	59	1	0	0	0	0	0	0	0	1	12676	962	34	4		4	PRSS1	7	142460802	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	13608520	142460802	16677861	60	12021											
NCAPG2	54892	broad.mit.edu	37	chr7	158454900	158454900	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttaccttaaatactttcaGatactctggaagcacagagg	14	11	7	9	0	2	2	1	0	1	2	2	3	2	3	1	2	4	1	1	2	6	5			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr7:158454900G>A	uc003wnv.1	-	16	2120	c.1975C>T	c.(1975-1977)CTG>TTG	p.L659L	NCAPG2_uc010lqu.1_Silent_p.L451L|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Silent_p.L659L|NCAPG2_uc011kwe.1_Silent_p.L659L|NCAPG2_uc011kwc.1_Silent_p.L160L|NCAPG2_uc011kwd.1_Intron	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	659					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		AATACTTTCAGATACTCTGGA	0.313													20	50					0	0	0	0	A	158454900	A	A	158454900	2	1	59	1	0	0	0	0	0	0	0	1	10262	933	33	2		2	NCAPG2	7	158454900	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	15994098	158454900	683763	61	12022											
ZFHX4	79776	broad.mit.edu	37	chr8	77619978	77619978	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgagcagtgagcgctctCtccctgaagaggaatggagg	10	8	15	8	1	1	4	0	3	1	1	3	6	2	6	1	3	2	2	1	3	2	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr8:77619978C>A	uc003yav.2	+	3	3097	c.2710C>A	c.(2710-2712)CTC>ATC	p.L904I	ZFHX4_uc003yat.1_Missense_Mutation_p.L904I|ZFHX4_uc003yau.1_Missense_Mutation_p.L930I|ZFHX4_uc003yaw.1_Missense_Mutation_p.L904I	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	904						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGAGCGCTCTCTCCCTGAAGA	0.512										HNSCC(33;0.089)			12	53					6.40141e-05	6.66814e-05	1	0	A	77619978	A	A	77619978	3	1	59	1	0	0	0	0	1	0	0	0	17702	913	32	2	2794	2	ZFHX4	8	77619978	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08		77619978	68744044	62	12023											
FAM164A	51101	broad.mit.edu	37	chr8	79598823	79598823	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcaaacttcctcctcctcCtccaccttcttatgatcctg	6	14	4	17	0	1	1	0	1	1	0	7	1	7	1	7	1	1	1	7	1	2	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr8:79598823C>T	uc003ybd.2	+	4	434	c.332C>T	c.(331-333)CCT>CTT	p.P111L		NM_016010	NP_057094	Q96GY0	F164A_HUMAN	hypothetical protein LOC51101	111										ovary(1)	1						CCTCCTCCTCCTCCACCTTCT	0.378													13	50					0	0	0	0	T	79598823	T	T	79598823	3	4	59	1	0	0	0	0	1	0	0	0	5506	681	24	4	346	4	FAM164A	8	79598823	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	1978845	79598823	66765199	63	12024											
FBXO43	286151	broad.mit.edu	37	chr8	101153460	101153460	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaatcttctgatttctccAagctaagtgagttaaaacca	13	12	8	8	0	3	2	0	2	3	0	4	3	3	3	2	1	2	2	2	1	5	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr8:101153460A>T	uc003yjd.2	-	2	1735	c.1022T>A	c.(1021-1023)TTG>TAG	p.L341*	FBXO43_uc003yje.2_Nonsense_Mutation_p.L307*|FBXO43_uc010mbp.1_Nonsense_Mutation_p.L341*	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	341					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TGATTTCTCCAAGCTAAGTGA	0.428													45	150					0	0	0	0	T	101153460	T	T	101153460	4	4	59	1	0	0	0	0	0	1	0	0	5784	131	5	5	1120	5	FBXO43	8	101153460	Nonsense_Mutation	SNP	A	TCGA-CN-5361-01A-01D-1434-08	21554637	101153460	45210562	64	12025											
GLI4	2738	broad.mit.edu	37	chr8	144358773	144358773	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatctggagctccgtgctCatcgagcaccagcgcatcca	8	9	9	15	3	3	0	2	0	1	0	6	2	5	1	3	1	4	4	3	1	0	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr8:144358773C>T	uc003yxx.2	+	4	1015	c.930C>T	c.(928-930)CTC>CTT	p.L310L	ZFP41_uc003yxv.2_RNA	NM_138465	NP_612474	P10075	GLI4_HUMAN	GLI-Kruppel family member GLI4	310	C2H2-type 5.					nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GCTCCGTGCTCATCGAGCACC	0.667													7	11					0	0	0	0	T	144358773	T	T	144358773	2	4	59	1	0	0	0	0	0	0	0	1	6477	813	29	2		2	GLI4	8	144358773	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	43205313	144358773	2005249	65	12026											
TXN	7295	broad.mit.edu	37	chr9	113013678	113013678	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgcaaggcccacaccacGtggctgagaagtcaactact	11	9	9	12	1	1	1	1	1	0	1	1	2	1	1	2	2	3	2	2	2	4	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr9:113013678G>A	uc004bep.1	-	2	152	c.89C>T	c.(88-90)ACG>ATG	p.T30M	TXN_uc004beq.1_Missense_Mutation_p.T30M	NM_003329	NP_003320	P10599	THIO_HUMAN	thioredoxin	30	Thioredoxin.				cell proliferation|cell-cell signaling|cellular component movement|electron transport chain|glycerol ether metabolic process|nucleobase, nucleoside and nucleotide interconversion|positive regulation of DNA binding|regulation of protein import into nucleus, translocation|response to radiation|signal transduction|transcription, DNA-dependent|transport	cytosol|extracellular region|nucleoplasm	electron carrier activity|protein binding|protein disulfide oxidoreductase activity				0				OV - Ovarian serous cystadenocarcinoma(323;7.36e-07)		CCCACACCACGTGGCTGAGAA	0.383													16	45					0	0	0	0	A	113013678	A	A	113013678	3	1	59	1	0	0	0	0	1	0	0	0	16858	1145	40	1	244	1	TXN	9	113013678	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08		113013678	28199753	66	12027											
SLC34A3	142680	broad.mit.edu	37	chr9	140128317	140128317	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctccctgccctccccagacCcaggagaacagcagctgtgg	8	5	10	18	0	0	2	0	0	0	2	2	3	2	2	6	2	4	2	6	2	1	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr9:140128317C>A	uc004cmf.1	+	9	1035	c.849C>A	c.(847-849)ACC>ACA	p.T283T	SLC34A3_uc004cmc.1_Silent_p.T140T|SLC34A3_uc004cmd.1_Silent_p.T283T|SLC34A3_uc011met.1_Silent_p.T283T	NM_080877	NP_543153	Q8N130	NPT2C_HUMAN	solute carrier family 34 (sodium phosphate),	283	Extracellular (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CTCCCCAGACCCAGGAGAACA	0.687													6	18					0.000274275	0.000283733	1	0	A	140128317	A	A	140128317	2	1	59	1	0	0	0	0	0	0	0	1	14633	610	22	4		4	SLC34A3	9	140128317	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	27114639	140128317	1085114	67	12028											
KIAA1217	56243	broad.mit.edu	37	chr10	24831690	24831691	+	Frame_Shift_Ins	INS	-	T	T																															aaaatggcccccaaatggaaINSttccaaaaggtgagttcacc																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr10:24831690_24831691insT	uc001iru.3	+	18	4006_4007	c.3603_3604insT	c.(3601-3606)GAATTCfs	p.E1201fs	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Frame_Shift_Ins_p.E1165fs|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irw.2_Frame_Shift_Ins_p.E884fs|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Frame_Shift_Ins_p.E884fs|KIAA1217_uc001iry.2_Intron|KIAA1217_uc001isa.1_Frame_Shift_Ins_p.E37fs	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1201_1202					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CCCAAATGGAATTCCAAAAGGT	0.426													---	---	---								T	24831691	T	T	24831690	7	5	59	1	0	1	1	0	0	0	0	0	8255	98	4	0	3673	0	KIAA1217	10	24831690	Frame_Shift_Ins	INS	-	TCGA-CN-5361-01A-01D-1434-08		24831690	110703057	68	12029											
MASTL	84930	broad.mit.edu	37	chr10	27459203	27459208	+	In_Frame_Del	DEL	GGGAAA	-	-																															ggatatctgaagagcaccttGggaaaagaagtttaaaaaga																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr10:27459203_27459208delGGGAAA	uc001itm.2	+	8	1954_1959	c.1315_1320delGGGAAA	c.(1315-1320)GGGAAAdel	p.GK439del	MASTL_uc001itl.2_In_Frame_Del_p.GK439del|MASTL_uc009xkw.1_In_Frame_Del_p.GK439del|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	439_440	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						AGAGCACCTTGGGAAAAGAAGTTTAA	0.34													---	---	---								-	27459208	-	-	27459203	7	5	59	1	0	1	0	1	0	0	0	0	9381	1348	47	0	1345	0	MASTL	10	27459203	In_Frame_Del	DEL	GGGAAA	TCGA-CN-5361-01A-01D-1434-08	2627513	27459203	108075544	69	12030											
PARD3	56288	broad.mit.edu	37	chr10	34671476	34671476	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gataggtcgtacctttcttaAgctggatattaagcctcttg	9	15	9	8	1	2	0	0	0	2	0	3	2	2	1	2	2	3	2	2	2	5	7			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr10:34671476A>C	uc010qej.1	-	9	1391	c.1391T>G	c.(1390-1392)CTT>CGT	p.L464R	PARD3_uc010qek.1_Missense_Mutation_p.L464R|PARD3_uc010qel.1_Missense_Mutation_p.L464R|PARD3_uc010qem.1_Missense_Mutation_p.L464R|PARD3_uc010qen.1_Missense_Mutation_p.L464R|PARD3_uc010qeo.1_Missense_Mutation_p.L464R|PARD3_uc010qep.1_Missense_Mutation_p.L420R|PARD3_uc010qeq.1_Missense_Mutation_p.L420R|PARD3_uc001ixo.1_Missense_Mutation_p.L194R|PARD3_uc001ixp.1_Missense_Mutation_p.L329R|PARD3_uc001ixq.1_Missense_Mutation_p.L464R|PARD3_uc001ixr.1_Missense_Mutation_p.L464R|PARD3_uc001ixt.1_Missense_Mutation_p.L285R|PARD3_uc001ixu.1_Missense_Mutation_p.L420R|PARD3_uc001ixs.1_Missense_Mutation_p.L117R	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	464	PDZ 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				ACCTTTCTTAAGCTGGATATT	0.393													47	142					0	0	0	0	C	34671476	C	C	34671476	3	2	59	1	0	0	0	0	1	0	0	0	11497	72	3	5	2782	5	PARD3	10	34671476	Missense_Mutation	SNP	A	TCGA-CN-5361-01A-01D-1434-08	7212273	34671476	100863271	70	12031											
MYPN	84665	broad.mit.edu	37	chr10	69908207	69908207	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttggtggcccaacctcgtGtggcaaccatccagcaggta	9	9	11	12	1	0	0	0	0	0	0	2	0	1	0	4	4	3	3	4	4	3	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr10:69908207G>T	uc001jnm.3	+	6	1413	c.1228G>T	c.(1228-1230)GTG>TTG	p.V410L	MYPN_uc001jnl.1_Missense_Mutation_p.V410L|MYPN_uc001jnn.3_Missense_Mutation_p.V135L|MYPN_uc001jno.3_Missense_Mutation_p.V410L|MYPN_uc001jnp.1_Missense_Mutation_p.V410L|MYPN_uc009xps.2_Missense_Mutation_p.V410L|MYPN_uc009xpt.2_Missense_Mutation_p.V410L|MYPN_uc010qit.1_Missense_Mutation_p.V116L|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	410	Interaction with CARP.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CCAACCTCGTGTGGCAACCAT	0.527													23	67					2.32416e-17	2.56341e-17	1	0	T	69908207	T	T	69908207	3	4	59	1	0	0	0	0	1	0	0	0	10151	1377	48	4	1242	4	MYPN	10	69908207	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	35236731	69908207	65626540	71	12032											
CDH23	64072	broad.mit.edu	37	chr10	73553321	73553321	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctagagtaccacattgtCggcattgtggccaaggacga	12	8	12	9	2	0	1	0	0	0	1	1	3	0	2	2	3	2	3	2	3	4	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr10:73553321C>A	uc001jrx.3	+	46	7013	c.6636C>A	c.(6634-6636)GTC>GTA	p.V2212V	CDH23_uc001jsg.3_5'Flank|CDH23_uc001jsh.3_5'Flank	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2212	Cadherin 21.|Extracellular (Potential).			EFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVG IVAKDDTDRLVPNQEDAFAVNIN -> ASWEGQSHVTQAYE EAVGPPQPQVPDSTGDRHPLWGLGGFGQEHPWEGQILGGSS QAEPGLVWS (in Ref. 6; BAB61902).	calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						ACCACATTGTCGGCATTGTGG	0.537													18	43					3.52763e-06	3.70031e-06	1	0	A	73553321	A	A	73553321	2	1	59	1	0	0	0	0	0	0	0	1	3123	871	31	3		3	CDH23	10	73553321	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	3645114	73553321	61981426	72	12033											
PPP1R3C	5507	broad.mit.edu	37	chr10	93390209	93390209	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccggaaacttaagtaatcGgttgaaggctgagggaaatc	13	9	12	7	2	0	2	0	2	0	0	3	4	1	4	1	4	1	3	1	4	5	3	rs35287022	byFrequency	TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr10:93390209G>A	uc001kho.2	-	2	561	c.429C>T	c.(427-429)ACC>ACT	p.T143T		NM_005398	NP_005389	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	143	Interaction with EPM2A.						protein serine/threonine phosphatase activity			breast(1)	1		Colorectal(252;0.235)				TTAAGTAATCGGTTGAAGGCT	0.433													48	125					0	0	0	0	A	93390209	A	A	93390209	2	1	59	1	0	0	0	0	0	0	0	1	12433	1103	39	1		1	PPP1R3C	10	93390209	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	19836888	93390209	42144538	73	12034											
DDB2	1643	broad.mit.edu	37	chr11	47256422	47256422	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagtgaaaatttgggacctgCgccaggttagagggaaagcc	12	7	14	8	1	0	2	0	1	0	1	0	4	0	4	3	3	2	1	3	3	4	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr11:47256422C>T	uc001neb.2	+	6	1012	c.817C>T	c.(817-819)CGC>TGC	p.R273C	DDB2_uc001nec.2_Intron|DDB2_uc009yli.1_Missense_Mutation_p.R209C|DDB2_uc001ned.2_Intron|DDB2_uc001nee.2_Intron|DDB2_uc001nef.2_Intron|DDB2_uc001neg.2_Missense_Mutation_p.R132C|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	273	DWD box.|WD 3.		R -> H (in XP-E; impairs interaction with DDB1 and CUL4A).	R->A: Impairs interaction with DDB1.	nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						TTGGGACCTGCGCCAGGTTAG	0.537			Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				14	35					0	0	0	0	T	47256422	T	T	47256422	3	4	59	1	0	0	0	0	1	0	0	0	4341	768	27	1	839	1	DDB2	11	47256422	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08		47256422	87750094	74	12035											
OR5D18	219438	broad.mit.edu	37	chr11	55587681	55587681	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctccctttcttgctctgaTacttacatcaaccagtggct	7	15	5	14	0	4	1	1	1	3	0	5	1	4	1	2	1	4	2	2	1	3	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr11:55587681T>A	uc010rin.1	+	1	576	c.576T>A	c.(574-576)GAT>GAA	p.D192E		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				CTTGCTCTGATACTTACATCA	0.398													48	192					0	0	0	0	A	55587681	A	A	55587681	3	1	59	1	0	0	0	0	1	0	0	0	11211	1403	49	5	578	5	OR5D18	11	55587681	Missense_Mutation	SNP	T	TCGA-CN-5361-01A-01D-1434-08	8331259	55587681	79418835	75	12036											
SPTBN2	6712	broad.mit.edu	37	chr11	66463950	66463950	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagcgcctgtgcaggtctCtcagcttctccgacaccagg	6	8	10	17	2	3	0	1	0	2	0	5	1	3	0	4	2	3	2	4	2	0	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr11:66463950C>G	uc001ojd.2	-	20	4148	c.4076G>C	c.(4075-4077)AGA>ACA	p.R1359T		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1359	Spectrin 10.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GTGCAGGTCTCTCAGCTTCTC	0.587													75	236					0	0	0	0	G	66463950	G	G	66463950	3	3	59	1	0	0	0	0	1	0	0	0	15186	913	32	2	3168	2	SPTBN2	11	66463950	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	10876269	66463950	68542566	76	12037											
PITPNM1	9600	broad.mit.edu	37	chr11	67261028	67261028	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcatatccggccggcctgtGacatacacgatcaggtagcc	9	8	11	13	3	1	1	1	1	0	0	2	2	2	1	4	3	3	2	4	3	3	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr11:67261028G>A	uc001olx.2	-	21	3384	c.3195C>T	c.(3193-3195)GTC>GTT	p.V1065V	PITPNM1_uc001olw.2_Silent_p.V347V|PITPNM1_uc001oly.2_Silent_p.V1065V|PITPNM1_uc001olz.2_Silent_p.V1064V	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	1065					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						GCCGGCCTGTGACATACACGA	0.687													10	7					0	0	0	0	A	67261028	A	A	67261028	2	1	59	1	0	0	0	0	0	0	0	1	12005	1277	45	2		2	PITPNM1	11	67261028	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	797078	67261028	67745488	77	12038											
IGHMBP2	3508	broad.mit.edu	37	chr11	68696781	68696781	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggccagaaagtgcatcctGgcgggcgatcacaagcagct	12	5	13	11	2	1	1	1	0	0	1	2	2	2	1	2	3	3	3	2	3	3	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr11:68696781G>A	uc001ook.1	+	8	1293	c.1191G>A	c.(1189-1191)CTG>CTA	p.L397L	IGHMBP2_uc001ooj.1_RNA|IGHMBP2_uc001ool.1_5'Flank|IGHMBP2_uc001oom.1_5'Flank	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	397	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AGTGCATCCTGGCGGGCGATC	0.632													167	390					0	0	0	0	A	68696781	A	A	68696781	2	1	59	1	0	0	0	0	0	0	0	1	7630	1335	47	4		4	IGHMBP2	11	68696781	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	1435753	68696781	66309735	78	12039											
MRGPRD	116512	broad.mit.edu	37	chr11	68748063	68748063	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccggtgacacttgaaccaGatagggaagaggacagagag	14	4	16	7	1	0	5	0	2	0	3	0	8	0	7	2	4	1	0	2	4	3	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr11:68748063G>C	uc010rqf.1	-	1	393	c.393C>G	c.(391-393)ATC>ATG	p.I131M		NM_198923	NP_944605	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	131	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(1)	1			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ACTTGAACCAGATAGGGAAGA	0.577													16	142					0	0	0	0	C	68748063	C	C	68748063	3	2	59	1	0	0	0	0	1	0	0	0	9816	932	33	2	575	2	MRGPRD	11	68748063	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	51282	68748063	66258453	79	12040											
CCDC83	220047	broad.mit.edu	37	chr11	85627150	85627150	+	Frame_Shift_Del	DEL	T	-	-																															gatgagagcactatcttacaTcttagtcatgaaaatagcat																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr11:85627150delT	uc001pbh.1	+	10	1466	c.954delT	c.(952-954)CATfs	p.H318fs	CCDC83_uc001pbg.1_Frame_Shift_Del_p.H349fs|CCDC83_uc001pbi.1_RNA|CCDC83_uc001pbj.1_Frame_Shift_Del_p.H218fs	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	318										skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CTATCTTACATCTTAGTCATG	0.383													---	---	---								-	85627150	-	-	85627150	7	5	59	1	0	1	0	1	0	0	0	0	2870	1432	50	0	1085	0	CCDC83	11	85627150	Frame_Shift_Del	DEL	T	TCGA-CN-5361-01A-01D-1434-08	16879087	85627150	49379366	80	12041											
KCNJ1	3758	broad.mit.edu	37	chr11	128709328	128709328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaacaccactaattcaaagtCctgctggagaagggtctccg	13	8	9	11	1	2	1	1	0	1	1	4	2	3	1	3	2	2	1	3	2	4	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr11:128709328C>T	uc001qeo.1	-	2	919	c.868G>A	c.(868-870)GAC>AAC	p.D290N	KCNJ1_uc001qep.1_Missense_Mutation_p.D271N|KCNJ1_uc001qeq.1_Missense_Mutation_p.D271N|KCNJ1_uc001qer.1_Missense_Mutation_p.D271N|KCNJ1_uc001qes.1_Missense_Mutation_p.D271N	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	290	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	AATTCAAAGTCCTGCTGGAGA	0.478													37	72					0	0	0	0	T	128709328	T	T	128709328	3	4	59	1	0	0	0	0	1	0	0	0	8082	855	30	2	311	2	KCNJ1	11	128709328	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	43082178	128709328	6297188	81	12042											
ACAD8	27034	broad.mit.edu	37	chr11	134131693	134131693	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccgcgcggctgatggtccGcaatgcagcagtggctctgc	5	7	16	13	4	1	1	0	1	1	0	2	1	2	1	2	4	3	5	2	4	1	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr11:134131693G>A	uc001qhk.2	+	9	1062	c.1001G>A	c.(1000-1002)CGC>CAC	p.R334H	ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Missense_Mutation_p.R257H|ACAD8_uc001qhl.2_Missense_Mutation_p.R207H	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	334			R -> C (in IBDD).		branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		CTGATGGTCCGCAATGCAGCA	0.557													3	33					0	0	0	0	A	134131693	A	A	134131693	3	1	59	1	0	0	0	0	1	0	0	0	110	1087	38	1	1035	1	ACAD8	11	134131693	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	5422365	134131693	874823	82	12043											
B4GALNT3	283358	broad.mit.edu	37	chr12	663005	663005	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactgggaccagaccttcaGtgcccggaatctcgacttcc	10	8	9	14	2	2	1	1	0	1	1	4	4	3	3	4	2	2	0	4	2	2	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr12:663005G>A	uc001qii.1	+	14	1916	c.1916G>A	c.(1915-1917)AGT>AAT	p.S639N	B4GALNT3_uc001qij.1_Missense_Mutation_p.S542N|B4GALNT3_uc001qik.1_Missense_Mutation_p.S188N	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	639	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			CAGACCTTCAGTGCCCGGAAT	0.443													11	181					0	0	0	0	A	663005	A	A	663005	3	1	59	1	0	0	0	0	1	0	0	0	1270	1029	36	4	1970	4	B4GALNT3	12	663005	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08		663005	133188890	83	12044											
PDE3A	5139	broad.mit.edu	37	chr12	20833104	20833104	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatccctggaccagacccctCagtcgcactcttcagaacag	11	7	7	16	1	3	2	2	0	1	2	5	3	4	3	4	1	1	1	4	1	2	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr12:20833104C>T	uc001reh.1	+	16	3347	c.3325C>T	c.(3325-3327)CAG>TAG	p.Q1109*		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	1109					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCAGACCCCTCAGTCGCACTC	0.488													39	119					0	0	0	0	T	20833104	T	T	20833104	4	4	59	1	0	0	0	0	0	1	0	0	11691	827	29	2	3387	2	PDE3A	12	20833104	Nonsense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	20170099	20833104	113018791	84	12045											
SCN8A	6334	broad.mit.edu	37	chr12	52056740	52056740	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgatggcagtcatcgggagGacgatgaggacagcaagccc	11	4	15	11	3	1	1	1	1	0	0	2	6	1	4	2	4	2	2	2	4	1	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr12:52056740G>A	uc001ryw.2	+	2	317	c.139G>A	c.(139-141)GAC>AAC	p.D47N		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	47					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TCATCGGGAGGACGATGAGGA	0.552													43	111					0	0	0	0	A	52056740	A	A	52056740	3	1	59	1	0	0	0	0	1	0	0	0	13989	1174	41	2	141	2	SCN8A	12	52056740	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	31223636	52056740	81795155	85	12046											
ANKRD52	283373	broad.mit.edu	37	chr12	56638175	56638175	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagggccgtgttcttgttctCatccaacacagtaaggtctg	8	12	11	10	1	3	0	1	0	3	0	5	1	4	0	2	2	1	3	2	2	2	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr12:56638175C>T	uc001skm.3	-	25	2857	c.2767G>A	c.(2767-2769)GAG>AAG	p.E923K		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	923							protein binding			ovary(2)	2						TTCTTGTTCTCATCCAACACA	0.507													17	47					0	0	0	0	T	56638175	T	T	56638175	3	4	59	1	0	0	0	0	1	0	0	0	678	835	29	2	479	2	ANKRD52	12	56638175	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	4581435	56638175	77213720	86	12047											
HMGA2	8091	broad.mit.edu	37	chr12	66221845	66221845	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaggcagcaaaaacaagaGtccctctaaagcagctcaaa	19	4	7	11	0	2	1	1	0	1	1	3	1	3	1	1	1	4	4	1	1	7	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr12:66221845G>T	uc001ssx.2	+	2	987	c.176G>T	c.(175-177)AGT>ATT	p.S59I	RPSAP52_uc001sso.2_5'Flank|HMGA2_uc001ssw.1_Missense_Mutation_p.S59I|HMGA2_uc001ssp.1_RNA|HMGA2_uc010ssv.1_RNA|HMGA2_uc001sss.1_RNA|HMGA2_uc001sst.1_Missense_Mutation_p.S59I|HMGA2_uc001ssu.1_Missense_Mutation_p.S59I|HMGA2_uc001ssv.2_Missense_Mutation_p.S59I	NM_003483	NP_003474	P52926	HMGA2_HUMAN	high mobility group AT-hook 2 isoform a	59	Interaction with E4F1.				cell division|chromatin organization|mitosis|multicellular organismal development|regulation of growth|transcription, DNA-dependent	chromatin	AT DNA binding		HMGA2/LPP(161)|HMGA2/WIF1_ENST00000286574(14)|HMGA2/RAD51B(11)|HMGA2/NFIB_ENST00000397581(8)|HMGA2/FHIT_ENST00000476844(4)|HMGA2/CCNB1IP1(2)|HMGA2/ALDH2_ENST00000261733(2)|HMGA2/EBF1(2)|HMGA2/LHFP(2)|HMGA2/COX6C(2)	soft_tissue(159)|bone(27)|salivary_gland(22)	208	all_cancers(1;5.78e-46)		GBM - Glioblastoma multiforme(1;0.00179)|LUSC - Lung squamous cell carcinoma(43;0.156)	GBM - Glioblastoma multiforme(28;0.0386)		AAAAACAAGAGTCCCTCTAAA	0.463			T	LHFP|RAD51L1|LPP|HEI10|COX6C|CMKOR1|NFIB|ALDH2|CCNB1IP1|EBF1|WIF1|FHIT	lipoma|leiomyoma|pleiomorphic salivary gland adenoma								17	70					4.14922e-12	4.47757e-12	1	0	T	66221845	T	T	66221845	3	4	59	1	0	0	0	0	1	0	0	0	7263	1029	36	4	182	4	HMGA2	12	66221845	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	9583670	66221845	67630050	87	12048											
C12orf63	374467	broad.mit.edu	37	chr12	97158907	97158907	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattggaaagaagaatactaGaatgcataaagttaaccaag	20	9	8	4	0	0	3	0	0	0	3	0	4	0	4	1	1	3	2	1	1	11	6			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr12:97158907G>C	uc001tet.1	+	27	3545	c.3467G>C	c.(3466-3468)AGA>ACA	p.R1156T		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1156										skin(6)|ovary(1)	7						AAGAATACTAGAATGCATAAA	0.323													37	113					0	0	0	0	C	97158907	C	C	97158907	3	2	59	1	0	0	0	0	1	0	0	0	1712	942	33	2	3569	2	C12orf63	12	97158907	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	30937062	97158907	36692988	88	12049											
CAMKK2	10645	broad.mit.edu	37	chr12	121678561	121678561	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	catgcgtgcgggggagccggGggcgggggcccagcaacttt	5	5	20	11	4	0	0	0	0	0	0	0	1	0	1	2	6	5	1	2	6	1	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr12:121678561G>A	uc001tzu.2	-	17	1832	c.1708C>T	c.(1708-1710)CCC>TCC	p.P570S	CAMKK2_uc001tzt.2_3'UTR|CAMKK2_uc001tzv.2_Missense_Mutation_p.P570S|CAMKK2_uc001tzw.2_Missense_Mutation_p.P527S|CAMKK2_uc001tzx.2_3'UTR|CAMKK2_uc001tzy.2_3'UTR|CAMKK2_uc001tzz.1_Intron|CAMKK2_uc001uaa.1_Intron	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase	570					calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGGGAGCCGGGGGCGGGGGCC	0.711													8	41					0	0	0	0	A	121678561	A	A	121678561	3	1	59	1	0	0	0	0	1	0	0	0	2619	1232	43	4	62	4	CAMKK2	12	121678561	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	24519654	121678561	12173334	89	12050											
WDR66	144406	broad.mit.edu	37	chr12	122359424	122359424	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggggaaggaggacaaaaaGattgtcatggaagaaactga	18	5	15	3	0	1	3	1	1	0	2	1	8	1	7	0	5	1	0	0	5	5	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr12:122359424G>C	uc009zxk.2	+	2	355	c.213G>C	c.(211-213)AAG>AAC	p.K71N		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	71	Glu-rich.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		aggaCAAAAAGATTGTCATGG	0.323													16	30					0	0	0	0	C	122359424	C	C	122359424	3	2	59	1	0	0	0	0	1	0	0	0	17385	933	33	2	215	2	WDR66	12	122359424	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	680863	122359424	11492471	90	12051											
NALCN	259232	broad.mit.edu	37	chr13	101759854	101759854	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttacgcgttgaagcgtgctcGgaccaccacccggcaaaagt	10	7	11	13	5	0	1	0	1	0	0	1	2	0	2	3	2	3	3	3	2	4	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr13:101759854G>A	uc001vox.1	-	22	2752	c.2563C>T	c.(2563-2565)CGA>TGA	p.R855*		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	855	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AAGCGTGCTCGGACCACCACC	0.507													60	68					0	0	0	0	A	101759854	A	A	101759854	4	1	59	1	0	0	0	0	0	1	0	0	10201	1124	39	1	2745	1	NALCN	13	101759854	Nonsense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08		101759854	13410024	91	12052											
PSME1	5720	broad.mit.edu	37	chr14	24607452	24607452	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccacaccaagctagaaggCttccacactcaaatctctaa	14	8	4	15	0	2	1	1	0	1	1	5	1	4	1	3	1	1	2	3	1	5	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr14:24607452C>G	uc001wmg.2	+	8	601	c.507C>G	c.(505-507)GGC>GGG	p.G169G	PSME1_uc001wmh.2_Silent_p.G169G	NM_006263	NP_006254	Q06323	PSME1_HUMAN	proteasome activator subunit 1 isoform 1	169					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|proteasome activator complex				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00831)		AGCTAGAAGGCTTCCACACTC	0.473													134	383					0	0	0	0	G	24607452	G	G	24607452	2	3	59	1	0	0	0	0	0	0	0	1	12768	784	28	4		4	PSME1	14	24607452	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08		24607452	82742088	92	12053											
BMP4	652	broad.mit.edu	37	chr14	54418769	54418769	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catctgcagaagtgtcgcctCgaagtcccgcaggagctcat	9	8	11	13	3	2	1	1	0	1	1	5	3	3	2	2	1	2	3	2	1	2	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr14:54418769C>T	uc001xal.3	-	2	359	c.172G>A	c.(172-174)GAG>AAG	p.E58K	BMP4_uc010aoh.2_Missense_Mutation_p.E58K|BMP4_uc001xao.3_Missense_Mutation_p.E58K|BMP4_uc001xan.3_Missense_Mutation_p.E58K	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	58					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0						AGTGTCGCCTCGAAGTCCCGC	0.607													29	81					0	0	0	0	T	54418769	T	T	54418769	3	4	59	1	0	0	0	0	1	0	0	0	1465	893	31	1	1062	1	BMP4	14	54418769	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	29811317	54418769	52930771	93	12054											
PRKCH	5583	broad.mit.edu	37	chr14	61857999	61857999	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataacccttaccgggagtttCactgaaggtaagaatgagtt	13	11	10	7	1	1	3	1	2	0	1	1	4	1	4	2	2	2	3	2	2	5	5			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr14:61857999C>T	uc001xfn.2	+	2	725	c.420C>T	c.(418-420)TTC>TTT	p.F140F	PRKCH_uc010tsa.1_Intron	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	140					intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		CCGGGAGTTTCACTGAAGGTA	0.338													28	86					0	0	0	0	T	61857999	T	T	61857999	2	4	59	1	0	0	0	0	0	0	0	1	12575	825	29	2		2	PRKCH	14	61857999	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	7439230	61857999	45491541	94	12055											
DISP2	85455	broad.mit.edu	37	chr15	40659622	40659622	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccttccctcaagtacagcCtgctcttcctgcccacccca	6	10	5	20	0	2	0	1	0	1	0	4	0	4	0	7	0	5	2	7	0	2	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr15:40659622C>A	uc001zlk.1	+	8	1398	c.1309C>A	c.(1309-1311)CTG>ATG	p.L437M		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	437					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CAAGTACAGCCTGCTCTTCCT	0.582													148	595					8.23634e-74	9.65196e-74	1	0	A	40659622	A	A	40659622	3	1	59	1	0	0	0	0	1	0	0	0	4562	680	24	4	1339	4	DISP2	15	40659622	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08		40659622	61871770	95	12056											
SPINT1	6692	broad.mit.edu	37	chr15	41145416	41145416	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtggaaaacacagattggcgCctactgcggggtgacacgga	11	6	15	9	3	0	2	0	1	0	1	0	4	0	4	1	5	3	0	1	5	3	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr15:41145416C>A	uc001zna.2	+	3	774	c.570C>A	c.(568-570)CGC>CGA	p.R190R	SPINT1_uc001znb.2_Silent_p.R190R|SPINT1_uc001znc.2_Silent_p.R190R|SPINT1_uc010ucs.1_Silent_p.R190R	NM_181642	NP_857593	O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	190						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		CAGATTGGCGCCTACTGCGGG	0.617													46	145					2.24722e-20	2.53446e-20	1	0	A	41145416	A	A	41145416	2	1	59	1	0	0	0	0	0	0	0	1	15134	726	26	4		4	SPINT1	15	41145416	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	485794	41145416	61385976	96	12057											
CORO2B	10391	broad.mit.edu	37	chr15	69011053	69011053	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggggtcatgcccaagcaCgggctggatgtgtcagcctg	8	7	15	11	1	2	0	2	0	0	0	2	1	2	1	2	4	3	2	2	4	1	0	rs3751554	byFrequency	TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr15:69011053C>T	uc002arj.3	+	9	1013	c.984C>T	c.(982-984)CAC>CAT	p.H328H	CORO2B_uc010bic.2_Silent_p.H323H|CORO2B_uc002ark.2_Silent_p.H95H	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	328					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						TGCCCAAGCACGGGCTGGATG	0.592													7	40					0	0	0	0	T	69011053	T	T	69011053	2	4	59	1	0	0	0	0	0	0	0	1	3772	535	19	1		1	CORO2B	15	69011053	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	27865637	69011053	33520339	97	12058											
KIF23	9493	broad.mit.edu	37	chr15	69733141	69733141	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tattgctcagatttccaacgGccagcaactcatgagccagc	11	9	8	13	1	2	2	2	1	0	1	3	2	3	2	3	1	6	2	3	1	3	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr15:69733141G>A	uc002asb.2	+	18	2219	c.2102G>A	c.(2101-2103)GGC>GAC	p.G701D	KIF23_uc002asc.2_Intron|KIF23_uc010bii.2_Missense_Mutation_p.G591D|KIF23_uc010ukc.1_Intron	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	701					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						ATTTCCAACGGCCAGCAACTC	0.398													3	68					0	0	0	0	A	69733141	A	A	69733141	3	1	59	1	0	0	0	0	1	0	0	0	8330	1203	42	4	2172	4	KIF23	15	69733141	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	722088	69733141	32798251	98	12059											
SH2D7	646892	broad.mit.edu	37	chr15	78393518	78393518	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgagcccagaccagggtcCcacagagtctcccacttcct	8	7	10	16	0	1	3	0	1	1	2	4	3	3	3	5	2	1	0	5	2	0	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr15:78393518C>T	uc010blb.1	+	5	923	c.923C>T	c.(922-924)CCC>CTC	p.P308L		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	308											0						GACCAGGGTCCCACAGAGTCT	0.617													8	26					0	0	0	0	T	78393518	T	T	78393518	3	4	59	1	0	0	0	0	1	0	0	0	14304	623	22	4	941	4	SH2D7	15	78393518	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	8660377	78393518	24137874	99	12060											
KIF7	374654	broad.mit.edu	37	chr15	90176168	90176168	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccagctcctccagcgcccgCcgctgctgtagcaccttctc	4	8	8	21	3	1	0	0	0	1	0	4	0	3	0	6	0	4	5	6	0	1	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr15:90176168C>T	uc002bof.2	-	14	2855	c.2778G>A	c.(2776-2778)CGG>CGA	p.R926R	KIF7_uc010upw.1_Silent_p.R412R	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	926	Potential.				microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CCAGCGCCCGCCGCTGCTGTA	0.622													17	19					0	0	0	0	T	90176168	T	T	90176168	2	4	59	1	0	0	0	0	0	0	0	1	8348	726	26	4		4	KIF7	15	90176168	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	11782650	90176168	12355224	100	12061											
ZNF710	374655	broad.mit.edu	37	chr15	90611606	90611606	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccatgtctgcgtcgagtgcGgcctggacttctccaccctg	4	10	12	15	3	2	0	0	0	2	0	4	2	2	1	4	2	2	0	4	2	0	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr15:90611606G>A	uc002bov.1	+	2	1360	c.1237G>A	c.(1237-1239)GGC>AGC	p.G413S		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	413	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			CGTCGAGTGCGGCCTGGACTT	0.652													17	66					0	0	0	0	A	90611606	A	A	90611606	3	1	59	1	0	0	0	0	1	0	0	0	18182	1116	39	1	1239	1	ZNF710	15	90611606	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	435438	90611606	11919786	101	12062											
LRRK1	79705	broad.mit.edu	37	chr15	101588744	101588744	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcaggaacaggaaagtcAccatttacagttttacagga	17	8	9	7	0	1	0	1	0	0	0	1	3	1	3	1	3	4	2	1	3	5	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr15:101588744A>T	uc002bwr.2	+	22	3500	c.3181A>T	c.(3181-3183)ACC>TCC	p.T1061S	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_Intron	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1061					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CAGGAAAGTCACCATTTACAG	0.433													42	135					0	0	0	0	T	101588744	T	T	101588744	3	4	59	1	0	0	0	0	1	0	0	0	9082	159	6	5	3263	5	LRRK1	15	101588744	Missense_Mutation	SNP	A	TCGA-CN-5361-01A-01D-1434-08	10977138	101588744	942648	102	12063											
PRSS27	83886	broad.mit.edu	37	chr16	2762696	2762696	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggatccagttgtggtgggcGgtgacacggatgtagacacc	8	9	16	8	2	0	2	0	1	0	1	1	4	1	4	2	5	0	2	2	5	1	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr16:2762696G>A	uc002crf.2	-	6	1189	c.798C>T	c.(796-798)ACC>ACT	p.T266T	PRSS27_uc002cre.2_Silent_p.T230T|PRSS27_uc002crg.2_Silent_p.T164T	NM_031948	NP_114154	Q9BQR3	PRS27_HUMAN	marapsin precursor	266	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						TGTGGTGGGCGGTGACACGGA	0.662													5	8					0	0	0	0	A	2762696	A	A	2762696	2	1	59	1	0	0	0	0	0	0	0	1	12683	1103	39	1		1	PRSS27	16	2762696	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08		2762696	87592057	103	12064											
VWA3A	146177	broad.mit.edu	37	chr16	22144336	22144336	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacaccccctgcccgctatgCcagtcacactgacacagccg	9	5	7	20	2	1	1	1	1	0	0	1	1	1	1	5	0	3	1	5	0	1	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr16:22144336C>T	uc010vbq.1	+	20	2084	c.1988C>T	c.(1987-1989)GCC>GTC	p.A663V	VWA3A_uc010bxd.2_RNA|VWA3A_uc010bxc.2_Missense_Mutation_p.A671V	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	663	VWFA 1.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		GCCCGCTATGCCAGTCACACT	0.607													3	33					0	0	0	0	T	22144336	T	T	22144336	3	4	59	1	0	0	0	0	1	0	0	0	17308	739	26	4	2066	4	VWA3A	16	22144336	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	19381640	22144336	68210417	104	12065											
PLK1	5347	broad.mit.edu	37	chr16	23700659	23700659	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagtacatagagcgtgaCggcactgagtcctacctcac	10	8	10	13	2	1	3	1	2	0	1	2	3	2	3	2	1	4	3	2	1	3	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr16:23700659C>T	uc002dlz.1	+	8	1424	c.1371C>T	c.(1369-1371)GAC>GAT	p.D457D		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	457	POLO box 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		TAGAGCGTGACGGCACTGAGT	0.557													43	81					0	0	0	0	T	23700659	T	T	23700659	2	4	59	1	0	0	0	0	0	0	0	1	12149	535	19	1		1	PLK1	16	23700659	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	1556323	23700659	66654094	105	12066											
CDH13	1012	broad.mit.edu	37	chr16	83065808	83065808	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	attgtcggggggaaagacatCcagggctccttgcaggtaac	10	8	14	9	1	0	1	0	0	0	1	3	2	2	2	2	5	2	3	2	5	2	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr16:83065808C>G	uc002fgx.2	+	3	471	c.351C>G	c.(349-351)ATC>ATG	p.I117M	CDH13_uc010chh.2_Missense_Mutation_p.I117M|CDH13_uc010vns.1_Missense_Mutation_p.I164M|CDH13_uc010vnt.1_Intron|CDH13_uc010vnu.1_Missense_Mutation_p.I117M	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	117					adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GGAAAGACATCCAGGGCTCCT	0.468													10	24					0	0	0	0	G	83065808	G	G	83065808	3	3	59	1	0	0	0	0	1	0	0	0	3114	845	30	2	361	2	CDH13	16	83065808	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	59365149	83065808	7288945	106	12067											
ZC3H18	124245	broad.mit.edu	37	chr16	88691022	88691022	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcacagagagaagtcagtGaagaagccggccccgcctcc	11	5	11	14	2	2	4	2	1	1	3	4	5	3	4	5	1	1	0	5	1	3	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr16:88691022G>A	uc002fky.2	+	12	2111	c.1911G>A	c.(1909-1911)GTG>GTA	p.V637V	ZC3H18_uc010voz.1_Silent_p.V661V|ZC3H18_uc010chw.2_RNA|ZC3H18_uc002fkz.2_5'Flank	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	637	Ser-rich.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		AGAAGTCAGTGAAGAAGCCGG	0.667													13	37					0	0	0	0	A	88691022	A	A	88691022	2	1	59	1	0	0	0	0	0	0	0	1	17635	1277	45	2		2	ZC3H18	16	88691022	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	5625214	88691022	1663731	107	12068											
MYH3	4621	broad.mit.edu	37	chr17	10543464	10543464	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatctctttctcagtctctGcactcttgaggaggggcttg	5	14	10	12	0	4	1	1	1	4	0	7	2	4	2	1	3	1	2	1	3	0	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr17:10543464G>A	uc002gmq.1	-	21	2608	c.2531C>T	c.(2530-2532)GCA>GTA	p.A844V		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	844	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CTCAGTCTCTGCACTCTTGAG	0.468													50	86					0	0	0	0	A	10543464	A	A	10543464	3	1	59	1	0	0	0	0	1	0	0	0	10089	1319	46	4	3371	4	MYH3	17	10543464	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08		10543464	70651746	108	12069											
SREBF1	6720	broad.mit.edu	37	chr17	17716991	17716991	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggcctgctgctggtgccCtgggctgctggggccggggc	0	8	21	12	1	0	0	0	0	0	0	0	0	0	0	3	8	4	4	3	8	0	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr17:17716991C>T	uc002gru.1	-	17	3188	c.2994G>A	c.(2992-2994)CAG>CAA	p.Q998Q	SREBF1_uc002gro.3_5'Flank|SREBF1_uc002grp.1_Silent_p.Q617Q|SREBF1_uc002grq.1_Silent_p.Q517Q|SREBF1_uc002grr.1_Silent_p.Q744Q|SREBF1_uc002grs.1_Silent_p.Q974Q|SREBF1_uc002grt.1_Silent_p.Q1028Q	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	998	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						TGCTGGTGCCCTGGGCTGCTG	0.716													2	2					0	0	0	0	T	17716991	T	T	17716991	2	4	59	1	0	0	0	0	0	0	0	1	15207	680	24	4		4	SREBF1	17	17716991	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	7173527	17716991	63478219	109	12070											
LIG3	3980	broad.mit.edu	37	chr17	33331461	33331462	+	Frame_Shift_Ins	INS	-	GC	GC																															gacaagaaccctgcggcccaINSgcaggtctccccagagtgga																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr17:33331461_33331462insGC	uc002hik.1	+	20	3074_3075	c.2966_2967insGC	c.(2965-2967)CAGfs	p.Q989fs	uc002hil.2_5'Flank	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	989	BRCT.				base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	CCTGCGGCCCAGCAGGTCTCCC	0.569								Other_BER_factors					---	---	---								GC	33331462	GC	GC	33331461	7	5	59	1	0	1	1	0	0	0	0	0	8823	188	7	0	3098	0	LIG3	17	33331461	Frame_Shift_Ins	INS	-	TCGA-CN-5361-01A-01D-1434-08	15614470	33331461	47863749	110	12071											
PTRH2	51651	broad.mit.edu	37	chr17	57775075	57775076	+	Frame_Shift_Ins	INS	-	A	A																															ttgtaggctgaaacagcagcINSatgagagcactgggcagcca																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr17:57775075_57775076insA	uc002ixt.2	-	2	389_390	c.264_265insT	c.(262-267)CATGCTfs	p.H88fs	PTRH2_uc002ixs.2_RNA	NM_016077	NP_057161	Q9Y3E5	PTH2_HUMAN	Bcl-2 inhibitor of transcription precursor	88_89					apoptosis|translation	mitochondrion	aminoacyl-tRNA hydrolase activity				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GAAACAGCAGCATGAGAGCACT	0.475													---	---	---								A	57775076	A	A	57775075	7	5	59	1	0	1	1	0	0	0	0	0	12882	710	25	0	278	0	PTRH2	17	57775075	Frame_Shift_Ins	INS	-	TCGA-CN-5361-01A-01D-1434-08	24443614	57775075	23420135	111	12072											
AATK	9625	broad.mit.edu	37	chr17	79095073	79095073	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgcagagagcggaaggctGgcaccacatccggcctcctg	8	6	13	14	2	1	1	0	0	1	1	3	3	3	2	4	4	2	3	4	4	1	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr17:79095073G>A	uc010dia.2	-	11	2743	c.2663C>T	c.(2662-2664)CCA>CTA	p.P888L	AATK_uc010dhz.2_RNA	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	888						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GCGGAAGGCTGGCACCACATC	0.657													4	28					0	0	0	0	A	79095073	A	A	79095073	3	1	59	1	0	0	0	0	1	0	0	0	26	1348	47	4	1477	4	AATK	17	79095073	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	21319998	79095073	2100137	112	12073											
BRD4	23476	broad.mit.edu	37	chr19	15350543	15350543	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccgcagcgaggggctgaaGggctcgctgcggatgatggg	6	5	21	9	4	0	2	0	2	0	0	1	4	0	3	1	6	2	4	1	6	1	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr19:15350543G>A	uc002nar.2	-	16	3594	c.3372C>T	c.(3370-3372)CCC>CCT	p.P1124P		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	1124					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			AGGGGCTGAAGGGCTCGCTGC	0.692			T	NUT|C15orf55	lethal midline carcinoma of young people								29	31					0	0	0	0	A	15350543	A	A	15350543	2	1	59	1	0	0	0	0	0	0	0	1	1509	987	35	4		4	BRD4	19	15350543	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08		15350543	43778440	113	12074											
KIAA0892	23383	broad.mit.edu	37	chr19	19431858	19431858	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaagccgccgcagcgcatcGaggcccgtacacacctgcag	9	4	11	17	5	1	0	1	0	0	0	2	1	1	0	4	1	4	4	4	1	2	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr19:19431858G>A	uc002nmk.3	+	1	229	c.190G>A	c.(190-192)GAG>AAG	p.E64K	SF4_uc002nmh.2_5'Flank|SF4_uc002nmi.2_5'Flank|SF4_uc002nmj.2_5'Flank|SF4_uc010xqr.1_5'Flank|SF4_uc010xqs.1_5'Flank	NM_015329	NP_056144	Q9Y6X3	SCC4_HUMAN	hypothetical protein LOC23383 precursor	64	Sufficient for interaction with NIPBL.				cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding				0						GCAGCGCATCGAGGCCCGTAC	0.672													6	21					0	0	0	0	A	19431858	A	A	19431858	3	1	59	1	0	0	0	0	1	0	0	0	8235	1059	37	1	192	1	KIAA0892	19	19431858	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	4081315	19431858	39697125	114	12075											
FCGBP	8857	broad.mit.edu	37	chr19	40367904	40367904	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcatagtggctgttttctggGcaggtgatctctgtgggcag	5	14	15	7	0	3	1	1	1	2	0	4	1	3	1	0	4	0	4	0	4	1	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr19:40367904G>T	uc002omp.3	-	29	13064	c.13056C>A	c.(13054-13056)TGC>TGA	p.C4352*		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4352	TIL 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGTTTTCTGGGCAGGTGATCT	0.617													45	167					1.32136e-16	1.44674e-16	1	0	T	40367904	T	T	40367904	4	4	59	1	0	0	0	0	0	1	0	0	5810	1195	42	4	3193	4	FCGBP	19	40367904	Nonsense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	20936046	40367904	18761079	115	12076											
CEACAM4	1089	broad.mit.edu	37	chr19	42128134	42128134	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccacaggaaggcctgggacGttgttttctgcagaaagggg	9	8	15	9	1	1	1	0	0	1	1	1	3	1	3	2	5	1	3	2	5	2	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr19:42128134G>A	uc002orh.1	-	3	543	c.432C>T	c.(430-432)AAC>AAT	p.N144N	CEACAM4_uc010xwd.1_Silent_p.N144N	NM_001817	NP_001808	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion	144	Extracellular (Potential).					integral to plasma membrane|membrane fraction					0						GGCCTGGGACGTTGTTTTCTG	0.602													37	74					0	0	0	0	A	42128134	A	A	42128134	2	1	59	1	0	0	0	0	0	0	0	1	3209	1136	40	1		1	CEACAM4	19	42128134	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	1760230	42128134	17000849	116	12077											
ZNF230	7773	broad.mit.edu	37	chr19	44514424	44514424	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	attctgtgtccttataggcgGcaagactattgcggaagcag	10	11	12	8	2	1	1	0	0	1	1	2	2	2	2	1	3	2	2	1	3	5	5			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr19:44514424G>A	uc002oyb.1	+	5	484	c.233G>A	c.(232-234)GGC>GAC	p.G78D		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	78					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CTTATAGGCGGCAAGACTATT	0.423													3	59					0	0	0	0	A	44514424	A	A	44514424	3	1	59	1	0	0	0	0	1	0	0	0	17851	1203	42	4	247	4	ZNF230	19	44514424	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	2386290	44514424	14614559	117	12078											
CLEC11A	6320	broad.mit.edu	37	chr19	51227677	51227677	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtccgcagtgggccgcctGgccggcctggacgcaggcct	3	6	16	16	4	0	0	0	0	0	0	1	1	1	1	6	5	0	2	6	5	0	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr19:51227677G>C	uc002psy.2	+	3	523	c.345G>C	c.(343-345)CTG>CTC	p.L115L		NM_002975	NP_002966	Q9Y240	CLC11_HUMAN	stem cell growth factor precursor	115					positive regulation of cell proliferation	cytoplasm|extracellular region	growth factor activity|sugar binding			ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TGGGCCGCCTGGCCGGCCTGG	0.701											OREG0025643	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	24					0	0	0	0	C	51227677	C	C	51227677	2	2	59	1	0	0	0	0	0	0	0	1	3511	1335	47	4		4	CLEC11A	19	51227677	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	6713253	51227677	7901306	118	12079											
TMC4	147798	broad.mit.edu	37	chr19	54664094	54664094	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagcgcgccgtgccaggaaGactttattctgcgcctcctg	7	9	11	14	4	1	1	0	0	1	1	2	2	2	2	4	1	3	0	4	1	2	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr19:54664094G>C	uc010erf.2	-	15	2220	c.2088C>G	c.(2086-2088)GTC>GTG	p.V696V	LENG1_uc002qdm.2_5'Flank|TMC4_uc002qdn.2_Silent_p.V410V|TMC4_uc002qdo.2_Silent_p.V690V	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	696	Cytoplasmic (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GTGCCAGGAAGACTTTATTCT	0.617													42	176					0	0	0	0	C	54664094	C	C	54664094	2	2	59	1	0	0	0	0	0	0	0	1	16053	929	33	2		2	TMC4	19	54664094	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	3436417	54664094	4464889	119	12080											
SYT5	6861	broad.mit.edu	37	chr19	55686277	55686278	+	Missense_Mutation	DNP	TC	CT	CT																															tcctcctacgtccatcttctTcaggtttttagcctccagga																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr19:55686277_55686278TC>CT	uc002qjm.1	-	6	1858_1859	c.798_799GA>AG	c.(796-801)CTGAAG>CTAGAG	p.K267E	SYT5_uc002qjp.2_Missense_Mutation_p.K263E|SYT5_uc002qjn.1_Missense_Mutation_p.K267E|SYT5_uc002qjo.1_Missense_Mutation_p.K266E	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	267	Cytoplasmic (Potential).|C2 2.				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		TCCATCTTCTTCAGGTTTTTAG	0.579													58	93					0	0	0	0	CT	55686278	CT	CT	55686277	3	2	59	1	0	0	0	0	1	0	0	0	15543	1792	62	5	373	5	SYT5	19	55686277	Missense_Mutation	DNP	TC	TCGA-CN-5361-01A-01D-1434-08	1022183	55686277	3442706	120	12081											
KIAA1755	85449	broad.mit.edu	37	chr20	36850904	36850904	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcatgctgcagcctggccagGgtggctccaccttcccgctg	4	9	12	16	1	1	0	1	0	0	0	3	0	3	0	5	3	3	4	5	3	0	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr20:36850904G>T	uc002xhy.1	-	10	2636	c.2364C>A	c.(2362-2364)ACC>ACA	p.T788T	KIAA1755_uc002xhx.1_Silent_p.T66T	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	788										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GCCTGGCCAGGGTGGCTCCAC	0.637											OREG0025921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	95					2.75727e-19	3.0865e-19	1	0	T	36850904	T	T	36850904	2	4	59	1	0	0	0	0	0	0	0	1	8296	1219	43	4		4	KIAA1755	20	36850904	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08		36850904	26174616	121	12082											
ZMYND8	23613	broad.mit.edu	37	chr20	45867756	45867756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggggccgtgacggtgaccGtggaggacgtgctggtggtg	4	7	21	9	5	0	2	0	2	0	0	0	4	0	4	3	7	1	1	3	7	0	0			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr20:45867756G>A	uc002xta.1	-	15	2605	c.2351C>T	c.(2350-2352)ACG>ATG	p.T784M	ZMYND8_uc010ghq.1_Missense_Mutation_p.T461M|ZMYND8_uc010ghr.1_Missense_Mutation_p.T759M|ZMYND8_uc002xst.1_Missense_Mutation_p.T712M|ZMYND8_uc002xsu.1_Intron|ZMYND8_uc002xsv.1_Missense_Mutation_p.T712M|ZMYND8_uc002xsw.1_Missense_Mutation_p.T536M|ZMYND8_uc002xsx.1_Missense_Mutation_p.T536M|ZMYND8_uc002xsy.1_Missense_Mutation_p.T759M|ZMYND8_uc002xsz.1_Missense_Mutation_p.T721M|ZMYND8_uc010zxy.1_Missense_Mutation_p.T811M|ZMYND8_uc002xtb.1_Missense_Mutation_p.T804M|ZMYND8_uc002xss.2_Missense_Mutation_p.T784M|ZMYND8_uc010zxz.1_Intron|ZMYND8_uc002xtc.1_Missense_Mutation_p.T804M|ZMYND8_uc002xtd.1_Missense_Mutation_p.T779M|ZMYND8_uc002xte.1_Missense_Mutation_p.T784M|ZMYND8_uc010zya.1_Missense_Mutation_p.T784M|ZMYND8_uc002xtf.1_Missense_Mutation_p.T804M|ZMYND8_uc002xtg.2_Missense_Mutation_p.T778M|ZMYND8_uc010ghs.1_Missense_Mutation_p.T778M|ZMYND8_uc002xsr.1_Translation_Start_Site	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	784							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GACGGTGACCGTGGAGGACGT	0.692													36	93					0	0	0	0	A	45867756	A	A	45867756	3	1	59	1	0	0	0	0	1	0	0	0	17778	1145	40	1	1191	1	ZMYND8	20	45867756	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	9016852	45867756	17157764	122	12083											
STAU1	6780	broad.mit.edu	37	chr20	47752436	47752436	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacttatttcagatttattGagattttcttcttcggattc	8	21	6	6	1	3	3	1	2	2	2	5	5	3	4	0	1	0	0	0	1	2	10			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr20:47752436G>C	uc002xud.2	-	6	954	c.543C>G	c.(541-543)CTC>CTG	p.L181L	STAU1_uc002xua.2_Silent_p.L100L|STAU1_uc002xub.2_Silent_p.L100L|STAU1_uc002xuc.2_Silent_p.L100L|STAU1_uc002xue.2_Silent_p.L100L|STAU1_uc002xuf.2_Silent_p.L100L|STAU1_uc002xug.2_Silent_p.L181L	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	181						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			CAGATTTATTGAGATTTTCTT	0.284													12	54					0	0	0	0	C	47752436	C	C	47752436	2	2	59	1	0	0	0	0	0	0	0	1	15338	1277	45	2		2	STAU1	20	47752436	Silent	SNP	G	TCGA-CN-5361-01A-01D-1434-08	1884680	47752436	15273084	123	12084											
CYP24A1	1591	broad.mit.edu	37	chr20	52779266	52779266	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccacccttaccgtttccaccGcagccagctggagctctgtg	6	9	9	17	2	1	0	0	0	1	0	2	1	2	1	6	1	4	4	6	1	1	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr20:52779266G>T	uc002xwv.2	-	7	1378	c.980C>A	c.(979-981)GCG>GAG	p.A327E	CYP24A1_uc002xwu.1_Missense_Mutation_p.A185E|CYP24A1_uc002xww.2_Missense_Mutation_p.A327E	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	327					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CGTTTCCACCGCAGCCAGCTG	0.418													26	64					3.73148e-12	4.05595e-12	1	0	T	52779266	T	T	52779266	3	4	59	1	0	0	0	0	1	0	0	0	4171	1087	38	3	584	3	CYP24A1	20	52779266	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	5026830	52779266	10246254	124	12085											
SLC2A4RG	56731	broad.mit.edu	37	chr20	62372799	62372801	+	In_Frame_Del	DEL	CTT	-	-																															gcctgtccaccagccctctcCttctgggggccccggttgca																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr20:62372799_62372801delCTT	uc002ygq.2	+	3	413_415	c.358_360delCTT	c.(358-360)CTTdel	p.L121del	SLC2A4RG_uc002ygr.2_In_Frame_Del_p.L16del|SLC2A4RG_uc011abj.1_In_Frame_Del_p.L16del|SLC2A4RG_uc002ygs.2_5'UTR|SLC2A4RG_uc002ygt.2_5'Flank	NM_020062	NP_064446	Q9NR83	S2A4R_HUMAN	SLC2A4 regulator	121				SPLLL -> KPSPS (in Ref. 1; AAF97516).		cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					CAGCCCTCTCCTTCTGGGGGCCC	0.65													---	---	---								-	62372801	-	-	62372799	7	5	59	1	0	1	0	1	0	0	0	0	14611	681	24	0	368	0	SLC2A4RG	20	62372799	In_Frame_Del	DEL	CTT	TCGA-CN-5361-01A-01D-1434-08	9593533	62372799	652721	125	12086											
CXADR	1525	broad.mit.edu	37	chr21	18937987	18937987	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgatgattccagcacagAgcaaggatgggtctatagta	12	10	12	7	0	1	3	0	2	1	1	2	4	2	4	1	2	2	3	1	2	4	4			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr21:18937987A>G	uc002yki.2	+	7	1193	c.1075A>G	c.(1075-1077)AGC>GGC	p.S359G	CXADR_uc002ykj.1_Intron	NM_001338	NP_001329	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	359	Cytoplasmic (Potential).				blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			ovary(1)	1				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		TCCAGCACAGAGCAAGGATGG	0.458													28	71					0	0	0	0	G	18937987	G	G	18937987	3	3	59	1	0	0	0	0	1	0	0	0	4093	304	11	5	1101	5	CXADR	21	18937987	Missense_Mutation	SNP	A	TCGA-CN-5361-01A-01D-1434-08		18937987	29191908	126	12087											
DGCR2	9993	broad.mit.edu	37	chr22	19050747	19050747	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctcccagcgaccttccaagGagcggttccggccagtgata	8	7	11	15	3	0	1	0	1	0	0	3	3	3	2	6	3	2	1	6	3	2	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr22:19050747G>A	uc002zoq.1	-	5	841	c.593C>T	c.(592-594)TCC>TTC	p.S198F	DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Missense_Mutation_p.S154F	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	198	Extracellular (Potential).|C-type lectin.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					ACCTTCCAAGGAGCGGTTCCG	0.582													10	42					0	0	0	0	A	19050747	A	A	19050747	3	1	59	1	0	0	0	0	1	0	0	0	4483	1174	41	2	1083	2	DGCR2	22	19050747	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08		19050747	32253819	127	12088											
SULT4A1	25830	broad.mit.edu	37	chr22	44234792	44234792	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaattcttgaaaggtgcctcGgtagctcatggtccgcagag	9	10	13	9	2	2	2	1	1	1	1	4	3	3	2	2	3	2	3	2	3	3	3			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr22:44234792G>A	uc003bee.1	-	4	579	c.463C>T	c.(463-465)CGA>TGA	p.R155*	SULT4A1_uc003bed.1_Nonsense_Mutation_p.R76*|SULT4A1_uc003bef.1_RNA|SULT4A1_uc011aqb.1_Intron	NM_014351	NP_055166	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	155					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		AAGGTGCCTCGGTAGCTCATG	0.537													20	69					0	0	0	0	A	44234792	A	A	44234792	4	1	59	1	0	0	0	0	0	1	0	0	15449	1124	39	1	407	1	SULT4A1	22	44234792	Nonsense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	25184045	44234792	7069774	128	12089											
SCO2	9997	broad.mit.edu	37	chr22	50962708	50962708	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggccctgcccacctgtctCtgcagggccctgccttgaca	4	9	10	18	0	1	1	0	1	1	0	2	1	1	1	5	2	3	1	5	2	0	1			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr22:50962708C>T	uc003bma.2	-	2	309	c.133G>A	c.(133-135)GAG>AAG	p.E45K	SCO2_uc003blz.3_Missense_Mutation_p.E45K	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	45					cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCACCTGTCTCTGCAGGGCCC	0.692													29	63					0	0	0	0	T	50962708	T	T	50962708	3	4	59	1	0	0	0	0	1	0	0	0	13997	922	32	2	671	2	SCO2	22	50962708	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	6727916	50962708	341858	129	12090											
SCO2	9997	broad.mit.edu	37	chr22	50962761	50962761	+	Missense_Mutation	SNP	C	T	T																															tcagatgcagggcctggcctCccagggtcccagggaggacc																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr22:50962761C>T	uc003bma.2	-	2	256	c.80G>A	c.(79-81)GGA>GAA	p.G27E	SCO2_uc003blz.3_Missense_Mutation_p.G27E	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	27					cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGCCTGGCCTCCCAGGGTCCC	0.662													10	60					0	0	0	0	T	50962761	T	T	50962761	3	4	59	1	0	0	0	0	1	0	0	0	13997	855	30	2	724	2	SCO2	22	50962761	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08	53	50962761	341805	130	12091	26	2									
SCO2	9997	broad.mit.edu	37	chr22	50962769	50962769	+	Silent	SNP	C	T	T																															agggcctggcctcccagggtCccagggaggacccgaggctt																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chr22:50962769C>T	uc003bma.2	-	2	248	c.72G>A	c.(70-72)GGG>GGA	p.G24G	SCO2_uc003blz.3_Silent_p.G24G	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	24					cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTCCCAGGGTCCCAGGGAGGA	0.652													9	63					0	0	0	0	T	50962769	T	T	50962769	2	4	59	1	0	0	0	0	0	0	0	1	13997	842	30	2		2	SCO2	22	50962769	Silent	SNP	C	TCGA-CN-5361-01A-01D-1434-08	8	50962769	341797	131	12092	26	2									
MAGEB3	4114	broad.mit.edu	37	chrX	30254048	30254048	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgactacagccatcatgcctCggggtcagaagagtacgctc	10	8	11	12	2	2	3	2	1	0	2	4	3	2	3	2	2	4	2	2	2	3	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chrX:30254048C>T	uc004dca.1	+	5	744	c.7C>T	c.(7-9)CGG>TGG	p.R3W		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	3											0						CATCATGCCTCGGGGTCAGAA	0.562													24	23					0	0	0	0	T	30254048	T	T	30254048	3	4	59	1	0	0	0	0	1	0	0	0	9230	875	31	1	9	1	MAGEB3	23	30254048	Missense_Mutation	SNP	C	TCGA-CN-5361-01A-01D-1434-08		30254048	125016512	132	12093											
MED14	9282	broad.mit.edu	37	chrX	40571488	40571488	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcatcagcaaagagcctaGactgcaccagttgatggatg	12	9	10	10	0	2	3	2	1	1	2	3	4	2	4	2	1	3	3	2	1	2	2			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chrX:40571488G>T	uc004dex.3	-	7	979	c.839C>A	c.(838-840)TCT>TAT	p.S280Y	MED14_uc010nhe.1_Missense_Mutation_p.S164Y	NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	280	Interaction with STAT2.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						AAAGAGCCTAGACTGCACCAG	0.408													115	104					3.62976e-74	4.28711e-74	1	0	T	40571488	T	T	40571488	3	4	59	1	0	0	0	0	1	0	0	0	9485	942	33	2	3625	2	MED14	23	40571488	Missense_Mutation	SNP	G	TCGA-CN-5361-01A-01D-1434-08	10317440	40571488	114699072	133	12094											
RAB9B	51209	broad.mit.edu	37	chrX	103080242	103080242	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccactgtcacattagtaTcatctttggcactagtttct	9	15	7	10	0	4	0	2	0	2	0	4	0	4	0	1	2	0	3	1	2	3	5			TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chrX:103080242T>C	uc004ell.1	-	3	758	c.473A>G	c.(472-474)GAT>GGT	p.D158G	RAB9B_uc004eli.1_Intron	NM_016370	NP_057454	Q9NP90	RAB9B_HUMAN	RAB9B, member RAS oncogene family	158					Golgi to endosome transport|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(3)	3						CACATTAGTATCATCTTTGGC	0.473													129	95					0	0	0	0	C	103080242	C	C	103080242	3	2	59	1	0	0	0	0	1	0	0	0	13024	1435	50	5	136	5	RAB9B	23	103080242	Missense_Mutation	SNP	T	TCGA-CN-5361-01A-01D-1434-08	62508754	103080242	52190318	134	12095											
FLNA	2316	broad.mit.edu	37	chrX	153599568	153599569	+	Frame_Shift_Ins	INS	-	CG	CG																															tcgacgccgccgcccggagcINScgcgcctgctgcgctctggc																										TCGA-CN-5361-01A-01D-1434-08	TCGA-CN-5361-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eea0205-e539-48de-b94c-4bb68c74ec96	27a64fa5-cf94-4e91-b746-7ea70c6d3264	g.chrX:153599568_153599569insCG	uc004fkk.2	-	2	294_295	c.45_46insCG	c.(43-48)GCGGCTfs	p.A15fs	FLNA_uc010nuu.1_Frame_Shift_Ins_p.A15fs	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	15_16	Actin-binding.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCGCCCGGAGCCGCGCCTGCTG	0.718													---	---	---								CG	153599569	CG	CG	153599568	7	5	59	1	0	1	1	0	0	0	0	0	5965	739	26	0	8085	0	FLNA	23	153599568	Frame_Shift_Ins	INS	-	TCGA-CN-5361-01A-01D-1434-08	50519326	153599568	1670992	135	12096											
ACTRT2	140625	broad.mit.edu	37	chr1	2938694	2938694	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggtgctggctctctacgcCtctgcctgtgtcacgggcct	2	11	13	15	3	3	0	1	0	2	0	4	0	3	0	3	3	3	2	3	3	1	1	rs17845890		TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:2938694C>T	uc001ajz.2	+	1	649	c.444C>T	c.(442-444)GCC>GCT	p.A148A		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	148						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		CTCTCTACGCCTCTGCCTGTG	0.622													20	87					0	0	0	0	T	2938694	T	T	2938694	2	4	60	1	0	0	0	0	0	0	0	1	219	668	24	4		4	ACTRT2	1	2938694	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08		2938694	246311927	1	12097											
AJAP1	55966	broad.mit.edu	37	chr1	4715487	4715487	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctccccgaaacgtgaccaTgtggattcaacagcttttag	10	10	9	12	3	1	1	1	1	0	0	2	3	2	2	3	1	3	2	3	1	3	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:4715487T>C	uc001alm.1	+	1	383	c.2T>C	c.(1-3)ATG>ACG	p.M1T	AJAP1_uc001aln.2_Missense_Mutation_p.M1T	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	1	Extracellular (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		AACGTGACCATGTGGATTCAA	0.731													20	69					0	0	0	0	C	4715487	C	C	4715487	3	2	60	1	0	0	0	0	1	0	0	0	438	1464	51	5	4	5	AJAP1	1	4715487	Missense_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	1776793	4715487	244535134	2	12098											
CROCC	9696	broad.mit.edu	37	chr1	17263291	17263291	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagctggaggagcagctgcgGgacaaggtgctccgcgagaa	10	4	17	10	3	0	1	0	0	0	1	1	5	1	4	1	4	5	4	1	4	2	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:17263291G>A	uc001azt.2	+	9	1185	c.1116G>A	c.(1114-1116)CGG>CGA	p.R372R	CROCC_uc009voy.1_Silent_p.R75R|CROCC_uc009voz.1_Silent_p.R135R	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	372	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		AGCAGCTGCGGGACAAGGTGC	0.677													12	54					0	0	0	0	A	17263291	A	A	17263291	2	1	60	1	0	0	0	0	0	0	0	1	3908	1219	43	4		4	CROCC	1	17263291	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	12547804	17263291	231987330	3	12099											
EPHA10	284656	broad.mit.edu	37	chr1	38227191	38227191	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggggctgccaggctcccCttccgagtgcgccacgcacg	4	6	15	16	4	0	0	0	0	0	0	2	1	2	0	5	4	2	3	5	4	0	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:38227191C>T	uc009vvi.2	-	3	822	c.736G>A	c.(736-738)GGG>AGG	p.G246R	EPHA10_uc001cbw.3_Missense_Mutation_p.G246R	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	246	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCAGGCTCCCCTTCCGAGTGC	0.731													25	27					0	0	0	0	T	38227191	T	T	38227191	3	4	60	1	0	0	0	0	1	0	0	0	5190	681	24	4	2388	4	EPHA10	1	38227191	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	20963900	38227191	211023430	4	12100											
RLF	6018	broad.mit.edu	37	chr1	40702667	40702667	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aactacttaaccataaacaaAagcatgacgatctgcgttac	17	9	5	10	2	1	1	0	1	1	0	1	2	1	1	1	0	7	2	1	0	8	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:40702667A>G	uc001cfc.3	+	8	2324	c.2293A>G	c.(2293-2295)AAG>GAG	p.K765E	RLF_uc001cfd.3_Missense_Mutation_p.K456E	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	765	C2H2-type 4.				chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			CCATAAACAAAAGCATGACGA	0.393													46	194					0	0	0	0	G	40702667	G	G	40702667	3	3	60	1	0	0	0	0	1	0	0	0	13454	15	1	5	2323	5	RLF	1	40702667	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	2475476	40702667	208547954	5	12101											
C1orf123	54987	broad.mit.edu	37	chr1	53683848	53683848	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acagcagcaaacttacattgTaaggcttgatggtgctgctt	11	12	10	8	0	0	1	0	1	0	0	0	1	0	1	0	2	6	6	0	2	3	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:53683848T>A	uc001cvd.2	-	5	299	c.257A>T	c.(256-258)TAC>TTC	p.Y86F	C1orf123_uc001cvc.2_Missense_Mutation_p.Y24F|C1orf123_uc001cve.2_Missense_Mutation_p.Y67F	NM_017887	NP_060357	Q9NWV4	CA123_HUMAN	hypothetical protein LOC54987	86										pancreas(2)	2						ACTTACATTGTAAGGCTTGAT	0.488													6	32					0	0	0	0	A	53683848	A	A	53683848	3	1	60	1	0	0	0	0	1	0	0	0	2000	1638	57	5	241	5	C1orf123	1	53683848	Missense_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	12981181	53683848	195566773	6	12102											
C1orf175	374977	broad.mit.edu	37	chr1	55144987	55144987	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaggacctgctgctggccGccctggaagggctgaaaggc	9	6	15	11	1	0	1	0	1	0	0	0	3	0	3	3	5	2	3	3	5	4	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:55144987G>T	uc010ooe.1	+	12	2425	c.2101G>T	c.(2101-2103)GCC>TCC	p.A701S	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.A269S|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.A219S|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.A701S|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	701						integral to membrane	binding				0						GCTGCTGGCCGCCCTGGAAGG	0.592													39	197					6.2361e-21	8.11589e-21	1	0	T	55144987	T	T	55144987	3	4	60	1	0	0	0	0	1	0	0	0	2025	1087	38	3	2139	3	C1orf175	1	55144987	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	1461139	55144987	194105634	7	12103											
LRRC7	57554	broad.mit.edu	37	chr1	70555457	70555457	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccttggatttagtatcagTggtggaattagtggacaagg	10	12	15	4	0	1	0	1	0	0	0	1	3	1	3	1	6	0	1	1	6	5	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:70555457T>C	uc001dep.2	+	23	4416	c.4386T>C	c.(4384-4386)AGT>AGC	p.S1462S	LRRC7_uc009wbg.2_Silent_p.S746S|LRRC7_uc001deq.2_Silent_p.S656S	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1462	PDZ.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TTAGTATCAGTGGTGGAATTA	0.299													26	139					0	0	0	0	C	70555457	C	C	70555457	2	2	60	1	0	0	0	0	0	0	0	1	9070	1693	59	5		5	LRRC7	1	70555457	Silent	SNP	T	TCGA-CN-5363-01A-01D-1434-08	15410470	70555457	178695164	8	12104											
CRYZ	1429	broad.mit.edu	37	chr1	75172657	75172657	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtctcgtgggtttatttcaaTagtacctctgctgccaacaa	9	14	8	10	1	3	0	1	0	2	0	4	0	3	0	2	1	4	3	2	1	6	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:75172657T>A	uc001dgk.2	-	9	1259	c.754A>T	c.(754-756)ATT>TTT	p.I252F	CRYZ_uc001dgj.2_Missense_Mutation_p.I252F|CRYZ_uc001dgl.2_Missense_Mutation_p.I218F|CRYZ_uc001dgm.2_Missense_Mutation_p.I115F	NM_001130042	NP_001123514	Q08257	QOR_HUMAN	crystallin, zeta isoform a	252					protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)	TTTATTTCAATAGTACCTCTG	0.353													55	264					0	0	0	0	A	75172657	A	A	75172657	3	1	60	1	0	0	0	0	1	0	0	0	3937	1406	49	5	243	5	CRYZ	1	75172657	Missense_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	4617200	75172657	174077964	9	12105											
RBMXL1	494115	broad.mit.edu	37	chr1	89448494	89448495	+	In_Frame_Ins	INS	-	CAC	CAC																															ttcttgtctgccaaccctgtINScacaacttgagtagagatca																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:89448494_89448495insCAC	uc009wcx.2	-	3	1731_1732	c.1015_1016insGTG	c.(1015-1017)GAC>GGTGAC	p.338_339insG	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_In_Frame_Ins_p.338_339insG	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	338_339	Ser-rich.						nucleotide binding|RNA binding				0						GCCAACCCTGTCACAACTTGAG	0.505													---	---	---								CAC	89448495	CAC	CAC	89448494	7	5	60	1	0	1	1	0	0	0	0	0	13218	1667	58	0	160	0	RBMXL1	1	89448494	In_Frame_Ins	INS	-	TCGA-CN-5363-01A-01D-1434-08	14275837	89448494	159802127	10	12106											
CCDC18	343099	broad.mit.edu	37	chr1	93651989	93651989	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcaacagaatgcttgtttgGtcacacagaatcattcctta	12	12	8	9	0	2	2	2	0	0	2	3	2	3	2	1	2	2	3	1	2	4	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:93651989G>A	uc001dpq.2	+	4	913	c.745G>A	c.(745-747)GTC>ATC	p.V249I		NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	131	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TGCTTGTTTGGTCACACAGAA	0.343													29	78					0	0	0	0	A	93651989	A	A	93651989	3	1	60	1	0	0	0	0	1	0	0	0	2807	1261	44	4	759	4	CCDC18	1	93651989	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	4203495	93651989	155598632	11	12107											
IGSF3	3321	broad.mit.edu	37	chr1	117208931	117208931	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagccagacagctcagcacCgggaaaaagcacttcatgtc	14	5	9	13	1	2	1	2	0	0	1	3	2	2	2	2	1	4	3	2	1	2	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:117208931C>G	uc001egr.1	-	2	723	c.18G>C	c.(16-18)CCG>CCC	p.P6P	IGSF3_uc001egq.1_Silent_p.P6P	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	6						integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		AGCTCAGCACCGGGAAAAAGC	0.493													18	107					0	0	0	0	G	117208931	G	G	117208931	2	3	60	1	0	0	0	0	0	0	0	1	7640	639	23	3		3	IGSF3	1	117208931	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	23556942	117208931	132041690	12	12108											
GJA8	2703	broad.mit.edu	37	chr1	147380566	147380566	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatcttcaagaccctctttGaagtgggcttcatcgtgggc	7	13	10	11	1	5	2	3	1	2	1	6	2	5	2	1	2	0	1	1	2	2	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:147380566G>A	uc001epu.1	+	2	547	c.484G>A	c.(484-486)GAA>AAA	p.E162K		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	162	Helical; (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					GACCCTCTTTGAAGTGGGCTT	0.587													51	180					0	0	0	0	A	147380566	A	A	147380566	3	1	60	1	0	0	0	0	1	0	0	0	6442	1291	45	2	486	2	GJA8	1	147380566	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	30171635	147380566	101870055	13	12109											
FLG	2312	broad.mit.edu	37	chr1	152280937	152280937	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcctcctctgcttggccccGggtgtccacgaatggtgtcc	3	12	11	15	2	1	0	0	0	1	0	5	1	5	0	6	3	1	1	6	3	1	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:152280937G>T	uc001ezu.1	-	3	6461	c.6425C>A	c.(6424-6426)CCG>CAG	p.P2142Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2142	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTTGGCCCCGGGTGTCCACG	0.577									Ichthyosis				107	818					4.37601e-64	6.19935e-64	1	0	T	152280937	T	T	152280937	3	4	60	1	0	0	0	0	1	0	0	0	5954	1116	39	3	5764	3	FLG	1	152280937	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	4900371	152280937	96969684	14	12110											
LCE1A	353131	broad.mit.edu	37	chr1	152800041	152800041	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccactcctaagtgccccccAaagtgtccccctaagtgccc	8	7	6	20	0	0	0	0	0	0	0	2	0	2	0	8	0	2	0	8	0	3	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:152800041A>C	uc010pdw.1	+	1	93	c.93A>C	c.(91-93)CCA>CCC	p.P31P		NM_178348	NP_848125	Q5T7P2	LCE1A_HUMAN	late cornified envelope 1A	31	Cys-rich.				keratinization					ovary(1)|skin(1)	2	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			agtgccccccaaagtgtcccc	0.433													49	134					0	0	0	0	C	152800041	C	C	152800041	2	2	60	1	0	0	0	0	0	0	0	1	8699	117	5	5		5	LCE1A	1	152800041	Silent	SNP	A	TCGA-CN-5363-01A-01D-1434-08	519104	152800041	96450580	15	12111											
ASH1L	55870	broad.mit.edu	37	chr1	155340386	155340386	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcaatcaccatcccactatCcaggttcaggcagtagtggt	10	10	9	12	0	3	0	3	0	0	0	5	0	5	0	3	3	0	3	3	3	3	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:155340386C>A	uc009wqq.2	-	12	7090	c.6610G>T	c.(6610-6612)GAT>TAT	p.D2204Y	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.D2199Y	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2204	SET.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ATCCCACTATCCAGGTTCAGG	0.418													58	189					8.99859e-20	1.14375e-19	1	0	A	155340386	A	A	155340386	3	1	60	1	0	0	0	0	1	0	0	0	1043	855	30	2	2367	2	ASH1L	1	155340386	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	2540345	155340386	93910235	16	12112											
PAPPA2	60676	broad.mit.edu	37	chr1	176668318	176668318	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtaccacatgaacatgacGgtcccctgccccacagaagg	11	6	9	15	1	0	3	0	2	0	1	1	3	1	3	5	2	3	1	5	2	3	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:176668318G>A	uc001gkz.2	+	8	3993	c.2829G>A	c.(2827-2829)ACG>ACA	p.T943T	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	943					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGAACATGACGGTCCCCTGCC	0.602													50	152					0	0	0	0	A	176668318	A	A	176668318	2	1	60	1	0	0	0	0	0	0	0	1	11487	1103	39	1		1	PAPPA2	1	176668318	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	21327932	176668318	72582303	17	12113											
LAMC1	3915	broad.mit.edu	37	chr1	183093839	183093839	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aacggccctgtgagactttgCcgcctgtgccagtgcagtga	7	9	13	12	2	0	2	0	2	0	1	0	3	0	2	4	1	4	1	4	1	1	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:183093839C>T	uc001gpy.3	+	14	2732	c.2475C>T	c.(2473-2475)TGC>TGT	p.C825C		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	825	Laminin EGF-like 7.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAGACTTTGCCGCCTGTGCC	0.507													4	105					0	0	0	0	T	183093839	T	T	183093839	2	4	60	1	0	0	0	0	0	0	0	1	8654	747	26	4		4	LAMC1	1	183093839	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	6425521	183093839	66156782	18	12114											
PROX1	5629	broad.mit.edu	37	chr1	214178607	214178607	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctgaagacctacttctccGacgtaaaggtagggactttt	10	12	10	9	2	1	2	0	1	1	1	2	4	1	3	2	2	2	3	2	2	5	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:214178607G>A	uc001hkh.2	+	3	2097	c.1825G>A	c.(1825-1827)GAC>AAC	p.D609N		NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	609	Prospero-type homeobox.				aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CTACTTCTCCGACGTAAAGGT	0.378													22	97					0	0	0	0	A	214178607	A	A	214178607	3	1	60	1	0	0	0	0	1	0	0	0	12622	1058	37	1	1831	1	PROX1	1	214178607	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	31084768	214178607	35072014	19	12115											
PTPN14	5784	broad.mit.edu	37	chr1	214557343	214557343	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcacctcctggagagactGatgaaccaccggagagctgt	10	7	12	12	1	1	4	1	2	0	2	2	7	2	5	4	2	2	2	4	2	1	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:214557343G>C	uc001hkk.1	-	13	2126	c.1855C>G	c.(1855-1857)CAG>GAG	p.Q619E	PTPN14_uc010pty.1_Missense_Mutation_p.Q520E	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	619					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TGGAGAGACTGATGAACCACC	0.637													24	65					0	0	0	0	C	214557343	C	C	214557343	3	2	60	1	0	0	0	0	1	0	0	0	12846	1299	45	2	1736	2	PTPN14	1	214557343	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	378736	214557343	34693278	20	12116											
MIA3	375056	broad.mit.edu	37	chr1	222803588	222803588	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agatctgggaatgaacgaaaAtaacatatttgaagaggctg	17	9	11	4	1	1	4	0	2	1	2	1	6	1	5	0	2	2	1	0	2	7	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:222803588A>G	uc001hnl.2	+	4	3035	c.3026A>G	c.(3025-3027)AAT>AGT	p.N1009S	MIA3_uc009xea.1_Missense_Mutation_p.N845S	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1009	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		ATGAACGAAAATAACATATTT	0.433													35	140					0	0	0	0	G	222803588	G	G	222803588	3	3	60	1	0	0	0	0	1	0	0	0	9618	101	4	5	3040	5	MIA3	1	222803588	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	8246245	222803588	26447033	21	12117											
TRIM17	51127	broad.mit.edu	37	chr1	228596365	228596365	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcagaacccactgcccTccggcgaagagccgaggtag	9	5	13	14	3	0	2	0	0	0	2	1	4	1	2	4	2	5	3	4	2	3	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:228596365T>C	uc001hsu.2	-	7	1356	c.971A>G	c.(970-972)GAG>GGG	p.E324G	TRIM11_uc001hss.2_5'Flank|TRIM11_uc010pvx.1_5'Flank|TRIM11_uc001hst.1_5'Flank|TRIM17_uc001hsv.2_Missense_Mutation_p.E324G|TRIM17_uc001hsw.2_Missense_Mutation_p.E297G	NM_016102	NP_057186	Q9Y577	TRI17_HUMAN	tripartite motif-containing 17 isoform 1	324	B30.2/SPRY.				protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Prostate(94;0.0724)				CCCACTGCCCTCCGGCGAAGA	0.637													27	93					0	0	0	0	C	228596365	C	C	228596365	3	2	60	1	0	0	0	0	1	0	0	0	16560	1551	54	5	466	5	TRIM17	1	228596365	Missense_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	5792777	228596365	20654256	22	12118											
RYR2	6262	broad.mit.edu	37	chr1	237604656	237604656	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggtgagaaaagaagtagatgGcatgggaacatctgaaataa	18	7	13	3	0	1	4	0	2	1	3	1	6	1	5	0	3	1	2	0	3	7	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:237604656G>C	uc001hyl.1	+	13	1163	c.1043G>C	c.(1042-1044)GGC>GCC	p.G348A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	348	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAAGTAGATGGCATGGGAACA	0.398													28	114					0	0	0	0	C	237604656	C	C	237604656	3	2	60	1	0	0	0	0	1	0	0	0	13834	1203	42	4	1093	4	RYR2	1	237604656	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	9008291	237604656	11645965	23	12119											
RYR2	6262	broad.mit.edu	37	chr1	237758918	237758918	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccagcgggctgctcacAttcattgccaatggcaagga	9	8	12	12	1	2	0	2	0	0	0	2	1	2	1	2	3	4	4	2	3	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:237758918A>T	uc001hyl.1	+	34	4677	c.4557A>T	c.(4555-4557)ACA>ACT	p.T1519T		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1519	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCTGCTCACATTCATTGCCA	0.517													10	51					0	0	0	0	T	237758918	T	T	237758918	2	4	60	1	0	0	0	0	0	0	0	1	13834	204	8	5		5	RYR2	1	237758918	Silent	SNP	A	TCGA-CN-5363-01A-01D-1434-08	154262	237758918	11491703	24	12120											
OR2B11	127623	broad.mit.edu	37	chr1	247615247	247615247	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagaaggatgaaggctttaGgggagtcccctaagaagcta	13	7	13	8	0	0	3	0	1	0	2	1	5	1	5	3	4	1	2	3	4	6	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:247615247G>T	uc010pyx.1	-	1	38	c.38C>A	c.(37-39)CCT>CAT	p.P13H		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GAAGGCTTTAGGGGAGTCCCC	0.493													38	124					2.51541e-25	3.35388e-25	1	0	T	247615247	T	T	247615247	3	4	60	1	0	0	0	0	1	0	0	0	11042	1000	35	4	918	4	OR2B11	1	247615247	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	9856329	247615247	1635374	25	12121											
OR2L3	391192	broad.mit.edu	37	chr1	248224038	248224038	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcttattaggattcttcccaCcatcaagaattggccttttc	9	16	5	11	0	3	1	1	0	2	1	5	2	4	2	3	2	0	0	3	2	4	7			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr1:248224038C>A	uc001idx.1	+	1	55	c.55C>A	c.(55-57)CCA>ACA	p.P19T	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ATTCTTCCCACCATCAAGAAT	0.393													98	436					7.79711e-59	1.0876e-58	1	0	A	248224038	A	A	248224038	3	1	60	1	0	0	0	0	1	0	0	0	11062	507	18	4	57	4	OR2L3	1	248224038	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	608791	248224038	1026583	26	12122											
APOB	338	broad.mit.edu	37	chr2	21245717	21245717	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aattaccctccactgagcagCttgactggtctctttgggga	8	12	10	11	0	1	2	0	2	1	0	3	3	2	3	2	3	3	2	2	3	2	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:21245717C>A	uc002red.2	-	18	2930	c.2802G>T	c.(2800-2802)AAG>AAT	p.K934N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	934	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CACTGAGCAGCTTGACTGGTC	0.478													18	55					6.94344e-10	7.96885e-10	1	0	A	21245717	A	A	21245717	3	1	60	1	0	0	0	0	1	0	0	0	785	796	28	4	10937	4	APOB	2	21245717	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08		21245717	221953656	27	12123											
THADA	63892	broad.mit.edu	37	chr2	43776495	43776495	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cattcagaatcatctgtaagCggcttgctgactctgaggga	10	11	11	9	1	4	3	2	2	2	1	4	4	4	4	0	2	2	3	0	2	2	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:43776495C>A	uc002rsw.3	-	20	3312	c.2960G>T	c.(2959-2961)CGC>CTC	p.R987L	THADA_uc010far.2_Missense_Mutation_p.R256L|THADA_uc002rsx.3_Missense_Mutation_p.R987L|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Missense_Mutation_p.R696L|THADA_uc010fat.1_Missense_Mutation_p.R134L|THADA_uc002rta.2_Missense_Mutation_p.R697L	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	987							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CATCTGTAAGCGGCTTGCTGA	0.383													3	11					0.004672	0.00494468	1	0	A	43776495	A	A	43776495	3	1	60	1	0	0	0	0	1	0	0	0	15906	768	27	3	2977	3	THADA	2	43776495	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	22530778	43776495	199422878	28	12124											
NRXN1	9378	broad.mit.edu	37	chr2	50847323	50847323	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catccactgatattgtcaccTagataacaaagcacagggaa	16	8	7	10	0	1	2	1	1	0	1	2	3	2	3	2	1	2	1	2	1	5	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:50847323T>A	uc010fbq.2	-	8	2756	c.1279_splice	c.e8-1	p.V427_splice	NRXN1_uc002rxb.3_Splice_Site_p.V59_splice|NRXN1_uc002rxe.3_Splice_Site_p.V387_splice|NRXN1_uc002rxc.1_Splice_Site	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor						angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TATTGTCACCTAGATAACAAA	0.388													3	42					0	0	0	0	A	50847323	A	A	50847323	5	1	60	1	0	0	0	0	0	0	1	0	10719	1536	53	5	3693	5	NRXN1	2	50847323	Splice_Site	SNP	T	TCGA-CN-5363-01A-01D-1434-08	7070828	50847323	192352050	29	12125											
USP34	9736	broad.mit.edu	37	chr2	61508321	61508321	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgattgagtctcctccatcCagccctgacagggataactt	9	12	8	12	0	1	3	0	3	1	0	4	4	3	4	4	1	2	0	4	1	1	4	rs4645002		TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:61508321C>T	uc002sbe.2	-	38	5077	c.5055G>A	c.(5053-5055)CTG>CTA	p.L1685L	USP34_uc002sbf.2_5'Flank	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	1685					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CTCCTCCATCCAGCCCTGACA	0.403													9	32					0	0	0	0	T	61508321	T	T	61508321	2	4	60	1	0	0	0	0	0	0	0	1	17133	581	21	4		4	USP34	2	61508321	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	10660998	61508321	181691052	30	12126											
AFTPH	54812	broad.mit.edu	37	chr2	64780055	64780055	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgactttggagaatttgggGatataaatgctgtttcttgc	10	16	11	4	0	1	2	0	1	1	1	1	4	1	3	0	3	2	2	0	3	4	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:64780055G>T	uc002sdc.2	+	1	1479	c.1447G>T	c.(1447-1449)GAT>TAT	p.D483Y	AFTPH_uc002scz.2_Missense_Mutation_p.D483Y|AFTPH_uc002sda.2_Missense_Mutation_p.D483Y|AFTPH_uc002sdb.2_Missense_Mutation_p.D483Y	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	483					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						AGAATTTGGGGATATAAATGC	0.368													33	172					3.33393e-15	4.01252e-15	1	0	T	64780055	T	T	64780055	3	4	60	1	0	0	0	0	1	0	0	0	364	1174	41	2	1449	2	AFTPH	2	64780055	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	3271734	64780055	178419318	31	12127											
STAMBP	10617	broad.mit.edu	37	chr2	74089382	74089382	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtgaccatcacagaccttcGatgagcgtttgagtccaaca	12	9	9	11	2	1	4	1	3	0	1	3	5	2	4	3	0	2	1	3	0	1	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:74089382G>A	uc002sjs.2	+	10	1321	c.1271G>A	c.(1270-1272)CGA>CAA	p.R424Q	STAMBP_uc002sjt.2_Missense_Mutation_p.R424Q|STAMBP_uc002sju.2_Missense_Mutation_p.R424Q|STAMBP_uc002sjv.2_Missense_Mutation_p.R424Q	NM_201647	NP_964010	O95630	STABP_HUMAN	STAM binding protein	424					JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			ovary(1)|lung(1)|breast(1)|pancreas(1)	4						ACAGACCTTCGATGAGCGTTT	0.423													16	96					0	0	0	0	A	74089382	A	A	74089382	3	1	60	1	0	0	0	0	1	0	0	0	15316	1058	37	1	1305	1	STAMBP	2	74089382	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	9309327	74089382	169109991	32	12128											
REG3G	130120	broad.mit.edu	37	chr2	79254986	79254986	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtagcactgatgtgatgaaTtactttgcatgggagaaaaa	15	11	11	4	0	0	4	0	3	0	1	0	5	0	4	0	1	3	3	0	1	5	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:79254986T>C	uc002snw.2	+	5	472	c.387T>C	c.(385-387)AAT>AAC	p.N129N	REG3G_uc002snx.2_Silent_p.N129N|REG3G_uc010ffu.2_Silent_p.N83N	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	129	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						ATGTGATGAATTACTTTGCAT	0.507													34	169					0	0	0	0	C	79254986	C	C	79254986	2	2	60	1	0	0	0	0	0	0	0	1	13278	1490	52	5		5	REG3G	2	79254986	Silent	SNP	T	TCGA-CN-5363-01A-01D-1434-08	5165604	79254986	163944387	33	12129											
VWA3B	200403	broad.mit.edu	37	chr2	98828426	98828426	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaacaccctgagtgccctgAaaactgcttttgctgataaa	13	10	7	11	0	0	3	0	3	0	0	0	3	0	3	2	0	5	2	2	0	5	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:98828426A>T	uc002syo.2	+	13	2035	c.1771A>T	c.(1771-1773)AAA>TAA	p.K591*	VWA3B_uc010yvh.1_Nonsense_Mutation_p.K441*|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Nonsense_Mutation_p.K110*|VWA3B_uc002sym.2_Nonsense_Mutation_p.K591*|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Nonsense_Mutation_p.K248*|VWA3B_uc002syp.1_5'UTR|VWA3B_uc002syq.1_5'UTR|VWA3B_uc002syr.1_5'UTR	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	591	VWFA.									ovary(3)|large_intestine(2)|skin(1)	6						GAGTGCCCTGAAAACTGCTTT	0.443													28	98					0	0	0	0	T	98828426	T	T	98828426	4	4	60	1	0	0	0	0	0	1	0	0	17309	247	9	5	1817	5	VWA3B	2	98828426	Nonsense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	19573440	98828426	144370947	34	12130											
CHST10	9486	broad.mit.edu	37	chr2	101014428	101014428	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccactttgggagtctggcaGaaaagaatcttgtgcttgtc	9	12	11	9	0	2	2	0	0	2	2	3	3	2	3	1	2	1	2	1	2	3	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:101014428G>C	uc002tam.2	-	5	728	c.369C>G	c.(367-369)TTC>TTG	p.F123L		NM_004854	NP_004845	O43529	CHSTA_HUMAN	HNK-1 sulfotransferase	123	Lumenal (Potential).				carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				ovary(1)	1						GAGTCTGGCAGAAAAGAATCT	0.493													27	99					0	0	0	0	C	101014428	C	C	101014428	3	2	60	1	0	0	0	0	1	0	0	0	3413	933	33	2	713	2	CHST10	2	101014428	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	2186002	101014428	142184945	35	12131											
MYO7B	4648	broad.mit.edu	37	chr2	128331588	128331589	+	Frame_Shift_Del	DEL	GC	-	-																															ccccagcggggtgatcgaggGcgcgcgcatcgagcaatttc																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:128331588_128331589delGC	uc002top.2	+	7	739_740	c.686_687delGC	c.(685-687)GGCfs	p.G229fs		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	229	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GTGATCGAGGGCGCGCGCATCG	0.584													---	---	---								-	128331589	-	-	128331588	7	5	60	1	0	1	0	1	0	0	0	0	10136	1203	42	0	708	0	MYO7B	2	128331588	Frame_Shift_Del	DEL	GC	TCGA-CN-5363-01A-01D-1434-08	27317160	128331588	114867785	36	12132											
NCKAP5	344148	broad.mit.edu	37	chr2	133542068	133542068	+	Frame_Shift_Del	DEL	C	-	-																															ttgtgtgttggtttgaccagCttttgctgctgaggattttg																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:133542068delC	uc002ttp.2	-	14	2690	c.2316delG	c.(2314-2316)AAGfs	p.K772fs	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	772							protein binding				0						GTTTGACCAGCTTTTGCTGCT	0.423													---	---	---								-	133542068	-	-	133542068	7	5	60	1	0	1	0	1	0	0	0	0	10277	796	28	0	3441	0	NCKAP5	2	133542068	Frame_Shift_Del	DEL	C	TCGA-CN-5363-01A-01D-1434-08	5210480	133542068	109657305	37	12133											
SCN1A	6323	broad.mit.edu	37	chr2	166848385	166848385	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctcaaagtcatcctcactCagaggctctgcactttcttc	9	13	5	14	0	6	1	4	0	3	1	9	1	7	1	1	1	1	2	1	1	1	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:166848385C>T	uc010zcz.1	-	26	5385	c.5367G>A	c.(5365-5367)CTG>CTA	p.L1789L		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1800	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CATCCTCACTCAGAGGCTCTG	0.433													33	154					0	0	0	0	T	166848385	T	T	166848385	2	4	60	1	0	0	0	0	0	0	0	1	13979	813	29	2		2	SCN1A	2	166848385	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	33306317	166848385	76350988	38	12134											
NOSTRIN	115677	broad.mit.edu	37	chr2	169699618	169699618	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggaaaacacactagagaaCtgctaccaggtaagttatat	16	9	9	7	0	0	1	0	0	0	1	0	3	0	2	1	2	4	3	1	2	8	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:169699618C>T	uc002ueg.2	+	8	625	c.621C>T	c.(619-621)AAC>AAT	p.N207N	NOSTRIN_uc002uef.2_Silent_p.N207N|NOSTRIN_uc002uei.2_Silent_p.N90N|NOSTRIN_uc010fpu.2_Silent_p.N179N|NOSTRIN_uc002ueh.2_Silent_p.N129N|NOSTRIN_uc002uej.2_Silent_p.N90N	NM_001039724	NP_001034813	Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficker isoform 2	207	Potential.				endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0						CACTAGAGAACTGCTACCAGG	0.333													11	54					0	0	0	0	T	169699618	T	T	169699618	2	4	60	1	0	0	0	0	0	0	0	1	10600	564	20	4		4	NOSTRIN	2	169699618	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	2851233	169699618	73499755	39	12135											
CHN1	1123	broad.mit.edu	37	chr2	175666459	175666459	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagatgtgccatgaggtacCggagggtttcgcagtgagca	9	10	15	7	2	0	3	0	2	0	1	1	4	0	4	2	3	3	4	2	3	2	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:175666459C>G	uc002uji.2	-	12	1714	c.1184G>C	c.(1183-1185)CGG>CCG	p.R395P	CHN1_uc010zeq.1_Missense_Mutation_p.R369P|CHN1_uc002ujj.2_Missense_Mutation_p.R170P|CHN1_uc002ujg.2_Missense_Mutation_p.R270P	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	395	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity	p.R395Q(1)		ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			CATGAGGTACCGGAGGGTTTC	0.413			T	TAF15	extraskeletal myxoid chondrosarcoma								44	143					0	0	0	0	G	175666459	G	G	175666459	3	3	60	1	0	0	0	0	1	0	0	0	3377	652	23	3	203	3	CHN1	2	175666459	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	5966841	175666459	67532914	40	12136											
TTN	7273	broad.mit.edu	37	chr2	179447313	179447313	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taacagatgctggaggacccGgtttatctgaaggaataagg	13	9	13	6	1	1	2	0	1	1	1	1	5	1	5	1	5	2	2	1	5	5	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:179447313G>C	uc010zfg.1	-	263	58390	c.58166C>G	c.(58165-58167)CCG>CGG	p.P19389R	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P13084R|TTN_uc010zfi.1_Missense_Mutation_p.P13017R|TTN_uc010zfj.1_Missense_Mutation_p.P12892R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20316							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGAGGACCCGGTTTATCTGA	0.313													6	47					0	0	0	0	C	179447313	C	C	179447313	3	2	60	1	0	0	0	0	1	0	0	0	16803	1116	39	3	42305	3	TTN	2	179447313	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	3780854	179447313	63752060	41	12137											
TTN	7273	broad.mit.edu	37	chr2	179590124	179590124	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgtggccatgttctccCtcattccaccatcattcttg	6	15	6	14	0	5	0	3	0	2	0	7	0	6	0	4	1	0	1	4	1	0	4	rs2742326		TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:179590124C>G	uc010zfg.1	-	68	17299	c.17075G>C	c.(17074-17076)AGG>ACG	p.R5692T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R2353T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATGTTCTCCCTCATTCCACC	0.338													8	12					0	0	0	0	G	179590124	G	G	179590124	3	3	60	1	0	0	0	0	1	0	0	0	16803	681	24	4	83890	4	TTN	2	179590124	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	142811	179590124	63609249	42	12138											
KLF7	8609	broad.mit.edu	37	chr2	207953303	207953303	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagcacttataaggcttctCacctgcaagaagagatggaa	14	9	10	8	0	1	3	1	1	1	2	2	5	1	4	1	2	2	3	1	2	5	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:207953303C>T	uc002vbz.1	-	3	1058	c.736G>A	c.(736-738)GAG>AAG	p.E246K	KLF7_uc002vca.1_Silent_p.V178V|KLF7_uc010zix.1_Missense_Mutation_p.E218K	NM_003709	NP_003700	O75840	KLF7_HUMAN	Kruppel-like factor 7 (ubiquitous)	246					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			central_nervous_system(1)|skin(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)		TAAGGCTTCTCACCTGCAAGA	0.547													20	78					0	0	0	0	T	207953303	T	T	207953303	3	4	60	1	0	0	0	0	1	0	0	0	8390	835	29	2	180	2	KLF7	2	207953303	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	28363179	207953303	35246070	43	12139											
PIKFYVE	200576	broad.mit.edu	37	chr2	209169573	209169573	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcccaacactaaaagattCtgccagtcctagcaagcgca	13	8	6	14	1	1	1	0	0	1	1	3	1	3	1	3	0	4	2	3	0	5	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:209169573C>G	uc002vcz.2	+	12	1630	c.1472C>G	c.(1471-1473)TCT>TGT	p.S491C	PIKFYVE_uc010fun.1_Missense_Mutation_p.S172C|PIKFYVE_uc002vcy.1_Intron|PIKFYVE_uc002vcv.2_Missense_Mutation_p.S394C|PIKFYVE_uc002vcw.2_Missense_Mutation_p.S491C|PIKFYVE_uc002vcx.2_Missense_Mutation_p.S405C	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	491					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						CTAAAAGATTCTGCCAGTCCT	0.468													12	116					0	0	0	0	G	209169573	G	G	209169573	3	3	60	1	0	0	0	0	1	0	0	0	11979	913	32	2	1514	2	PIKFYVE	2	209169573	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	1216270	209169573	34029800	44	12140											
SPEG	10290	broad.mit.edu	37	chr2	220312735	220312735	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgcgcagggaggagcccgaCcttcagcctcaactggccag	8	6	13	14	2	2	0	2	0	0	0	2	3	2	2	4	3	4	1	4	3	1	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:220312735C>T	uc010fwg.2	+	4	855	c.855C>T	c.(853-855)GAC>GAT	p.D285D	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_5'UTR|SPEG_uc002vln.1_5'UTR|SPEG_uc002vlp.1_5'Flank	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	285	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGGAGCCCGACCTTCAGCCTC	0.672													12	34					0	0	0	0	T	220312735	T	T	220312735	2	4	60	1	0	0	0	0	0	0	0	1	15102	506	18	4		4	SPEG	2	220312735	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	11143162	220312735	22886638	45	12141											
USP40	55230	broad.mit.edu	37	chr2	234465564	234465564	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaacaatggttccatggtaCagacgatagatgaggtcatg	13	11	11	6	1	1	3	1	1	0	2	2	4	2	3	1	3	2	2	1	3	4	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr2:234465564C>A	uc010zmu.1	-	5	601	c.483G>T	c.(481-483)CTG>CTT	p.L161L	USP40_uc010zmr.1_Silent_p.L173L			Q9NVE5	UBP40_HUMAN	SubName: Full=cDNA FLJ56772, highly similar to Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15);	161					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		TTCCATGGTACAGACGATAGA	0.403													21	65					7.41877e-09	8.23635e-09	1	0	A	234465564	A	A	234465564	2	1	60	1	0	0	0	0	0	0	0	1	17140	465	17	4		4	USP40	2	234465564	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	14152829	234465564	8733809	46	12142											
CHL1	10752	broad.mit.edu	37	chr3	404935	404935	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgaaacccctggagggcaGgcggtatcatatctatgaaa	13	8	12	8	1	2	2	1	2	1	0	2	3	2	3	2	4	1	2	2	4	5	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:404935G>C	uc003bou.2	+	13	1677	c.1406G>C	c.(1405-1407)AGG>ACG	p.R469T	CHL1_uc003bot.2_Missense_Mutation_p.R485T|CHL1_uc003bow.1_Missense_Mutation_p.R469T|CHL1_uc011asi.1_Missense_Mutation_p.R485T	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	469	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CTGGAGGGCAGGCGGTATCAT	0.428													20	60					0	0	0	0	C	404935	C	C	404935	3	2	60	1	0	0	0	0	1	0	0	0	3364	1000	35	4	1500	4	CHL1	3	404935	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08		404935	197617495	47	12143											
RAD18	56852	broad.mit.edu	37	chr3	8944189	8944189	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccagaagctgaaattcaCtcttatgttttttacctgaa	12	14	5	10	0	2	3	1	2	1	1	2	3	2	3	3	0	2	2	3	0	5	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:8944189C>A	uc003brd.2	-	10	1120	c.1043G>T	c.(1042-1044)AGT>ATT	p.S348I	RAD18_uc003bre.2_RNA	NM_020165	NP_064550	Q9NS91	RAD18_HUMAN	postreplication repair protein hRAD18p	348					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			skin(3)|ovary(2)	5				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		CTGAAATTCACTCTTATGTTT	0.333								Rad6_pathway					33	93					2.19358e-23	2.91051e-23	1	0	A	8944189	A	A	8944189	3	1	60	1	0	0	0	0	1	0	0	0	13045	565	20	4	460	4	RAD18	3	8944189	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	8539254	8944189	189078241	48	12144											
ARPP21	10777	broad.mit.edu	37	chr3	35748546	35748546	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtttatcttgaagcgagataActctagtattgataaagaag	15	13	9	4	1	2	4	0	2	2	2	2	5	2	4	0	0	2	2	0	0	8	8			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:35748546A>T	uc003cgb.2	+	10	1031	c.767A>T	c.(766-768)AAC>ATC	p.N256I	ARPP21_uc003cga.2_Missense_Mutation_p.N256I|ARPP21_uc011axy.1_Missense_Mutation_p.N256I|ARPP21_uc003cgf.2_Missense_Mutation_p.N92I	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	256						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						AAGCGAGATAACTCTAGTATT	0.398													36	71					0	0	0	0	T	35748546	T	T	35748546	3	4	60	1	0	0	0	0	1	0	0	0	980	43	2	5	810	5	ARPP21	3	35748546	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	26804357	35748546	162273884	49	12145											
VILL	50853	broad.mit.edu	37	chr3	38035866	38035866	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggccttccagcagcgcctaCaggacgagctggggggccag	8	4	16	13	2	0	0	0	0	0	0	1	2	1	1	4	5	4	2	4	5	1	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:38035866C>A	uc003chj.2	+	4	536	c.250C>A	c.(250-252)CAG>AAG	p.Q84K	VILL_uc003chk.1_Missense_Mutation_p.Q84K|VILL_uc003chl.2_Missense_Mutation_p.Q84K|VILL_uc010hgu.2_5'UTR	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	84					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		GCAGCGCCTACAGGACGAGCT	0.701													14	24					1.05317e-09	1.19859e-09	1	0	A	38035866	A	A	38035866	3	1	60	1	0	0	0	0	1	0	0	0	17233	479	17	4	260	4	VILL	3	38035866	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	2287320	38035866	159986564	50	12146											
NSUN3	63899	broad.mit.edu	37	chr3	93781974	93781974	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagctctcagcgggacaatgCtgacccaggtgagacctggg	10	6	14	11	1	1	2	1	2	1	1	2	4	1	3	2	3	3	2	2	3	2	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:93781974C>T	uc003drl.1	+	1	120	c.4C>T	c.(4-6)CTG>TTG	p.L2L	DHFRL1_uc003dri.2_5'Flank|DHFRL1_uc003drj.2_5'UTR|NSUN3_uc003drk.2_RNA	NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	NOL1/NOP2/Sun domain family, member 3	2							methyltransferase activity			skin(1)	1						CGGGACAATGCTGACCCAGGT	0.572													55	186					0	0	0	0	T	93781974	T	T	93781974	2	4	60	1	0	0	0	0	0	0	0	1	10733	796	28	4		4	NSUN3	3	93781974	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	55746108	93781974	104240456	51	12147											
DHFRL1	200895	broad.mit.edu	37	chr3	93782067	93782067	+	5'Flank	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgagggagggtgctgggaTgggggaacatcacctttgtt	7	9	19	6	1	1	0	1	0	0	0	1	4	1	3	1	6	2	2	1	6	1	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:93782067T>G	uc003dri.2	-						DHFRL1_uc003drj.2_5'UTR|NSUN3_uc003drk.2_Intron|NSUN3_uc003drl.1_Intron	NM_176815	NP_789785	Q86XF0	DYRL1_HUMAN	dihydrofolate reductase-like 1						glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process		dihydrofolate reductase activity|NADP binding				0						GGTGCTGGGATGGGGGAACAT	0.577													27	83					0	0	0	0	G	93782067	G	G	93782067	1	3	60	0	1	0	0	0	0	0	0	0	4504	1479	51	5		5	DHFRL1	3	93782067	5'Flank	SNP	T	TCGA-CN-5363-01A-01D-1434-08	93	93782067	104240363	52	12148											
DZIP3	9666	broad.mit.edu	37	chr3	108403092	108403092	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttaggaagacctcttgtGaaagaatctttctttagacc	11	15	7	8	0	4	4	0	1	4	3	4	5	4	5	2	1	0	0	2	1	5	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:108403092G>C	uc003dxd.2	+	27	3335	c.2913G>C	c.(2911-2913)GTG>GTC	p.V971V	DZIP3_uc003dxf.1_Silent_p.V971V|DZIP3_uc011bhm.1_Silent_p.V422V	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	971					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GACCTCTTGTGAAAGAATCTT	0.413													117	417					0	0	0	0	C	108403092	C	C	108403092	2	2	60	1	0	0	0	0	0	0	0	1	4887	1277	45	2		2	DZIP3	3	108403092	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	14621025	108403092	89619338	53	12149											
FBXO40	51725	broad.mit.edu	37	chr3	121340297	121340297	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caggggaaagcccgcagatcCccgccagggcaccacaggca	11	1	13	16	2	0	1	0	0	0	1	1	2	1	2	5	4	1	3	5	4	1	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:121340297C>A	uc003eeg.2	+	3	231	c.21C>A	c.(19-21)TCC>TCA	p.S7S		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	7					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		CCCGCAGATCCCCGCCAGGGC	0.532													37	235					2.47316e-13	2.91212e-13	1	0	A	121340297	A	A	121340297	2	1	60	1	0	0	0	0	0	0	0	1	5781	610	22	4		4	FBXO40	3	121340297	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	12937205	121340297	76682133	54	12150											
CCDC14	64770	broad.mit.edu	37	chr3	123634533	123634533	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cactgtccacactaagatcgGagagaagctttgccatgcta	12	9	9	11	1	0	2	0	0	0	2	2	4	1	3	2	1	3	2	2	1	3	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:123634533G>A	uc011bjx.1	-	13	2046	c.1955C>T	c.(1954-1956)TCC>TTC	p.S652F	CCDC14_uc003egv.3_Missense_Mutation_p.S293F|CCDC14_uc003egx.3_Missense_Mutation_p.S452F|CCDC14_uc010hrt.2_Missense_Mutation_p.S611F|CCDC14_uc003egy.3_Missense_Mutation_p.S452F|CCDC14_uc003egz.2_Intron	NM_022757	NP_073594	Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	652						centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		ACTAAGATCGGAGAGAAGCTT	0.383													70	187					0	0	0	0	A	123634533	A	A	123634533	3	1	60	1	0	0	0	0	1	0	0	0	2785	1174	41	2	910	2	CCDC14	3	123634533	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	2294236	123634533	74387897	55	12151											
MED12L	116931	broad.mit.edu	37	chr3	151094808	151094808	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgtggccgaaatgaacaaCttactggacaatattgcaaa	15	10	8	8	1	1	1	0	1	1	0	1	3	1	2	1	2	4	1	1	2	7	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:151094808C>G	uc003eyp.2	+	28	4091	c.4053C>G	c.(4051-4053)AAC>AAG	p.N1351K	MED12L_uc011bnz.1_Missense_Mutation_p.N1211K|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.N514K	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1351					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAATGAACAACTTACTGGACA	0.398													22	82					0	0	0	0	G	151094808	G	G	151094808	3	3	60	1	0	0	0	0	1	0	0	0	9482	564	20	4	4163	4	MED12L	3	151094808	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	27460275	151094808	46927622	56	12152											
TIPARP	25976	broad.mit.edu	37	chr3	156411959	156411959	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtagggaccactttggAtggagagagtatcccgaggt	9	11	14	7	1	1	1	0	0	1	1	2	6	2	4	2	4	0	2	2	4	2	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:156411959A>T	uc003fav.2	+	3	1316	c.1068A>T	c.(1066-1068)GGA>GGT	p.G356G	TIPARP_uc003faw.2_Silent_p.G356G	NM_015508	NP_056323	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	356	WWE.						NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|breast(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			ACCACTTTGGATGGAGAGAGT	0.373													69	225					0	0	0	0	T	156411959	T	T	156411959	2	4	60	1	0	0	0	0	0	0	0	1	15990	320	12	5		5	TIPARP	3	156411959	Silent	SNP	A	TCGA-CN-5363-01A-01D-1434-08	5317151	156411959	41610471	57	12153											
LEKR1	389170	broad.mit.edu	37	chr3	156710895	156710895	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttaaggaaaaagaagactCtttaatgacttgtcaacaga	17	10	8	6	0	2	4	1	1	1	3	2	5	2	5	0	1	1	1	0	1	6	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:156710895C>T	uc003fba.1	+	10	1361	c.26C>T	c.(25-27)TCT>TTT	p.S9F		NM_001004316	NP_001004316	Q6ZMV7	LEKR1_HUMAN	leucine, glutamate and lysine rich 1	70											0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AAAGAAGACTCTTTAATGACT	0.318													22	87					0	0	0	0	T	156710895	T	T	156710895	3	4	60	1	0	0	0	0	1	0	0	0	8757	913	32	2	968	2	LEKR1	3	156710895	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	298936	156710895	41311535	58	12154											
SLITRK3	22865	broad.mit.edu	37	chr3	164905718	164905718	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttgtcttctccaggacttcGaggtaatccggcttggtttg	5	15	12	9	2	2	0	0	0	2	0	5	2	3	1	2	4	0	4	2	4	1	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:164905718G>A	uc003fej.3	-	2	3345	c.2901C>T	c.(2899-2901)CTC>CTT	p.L967L	SLITRK3_uc003fek.2_Silent_p.L967L	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	967	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CCAGGACTTCGAGGTAATCCG	0.388										HNSCC(40;0.11)			79	270					0	0	0	0	A	164905718	A	A	164905718	2	1	60	1	0	0	0	0	0	0	0	1	14808	1045	37	1		1	SLITRK3	3	164905718	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	8194823	164905718	33116712	59	12155											
SLITRK3	22865	broad.mit.edu	37	chr3	164906404	164906404	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggggatgtactcatacaCatgacccacgggaggggcct	9	7	15	10	1	1	1	1	1	0	0	1	3	1	3	2	5	2	1	2	5	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:164906404C>T	uc003fej.3	-	2	2659	c.2215G>A	c.(2215-2217)GTG>ATG	p.V739M	SLITRK3_uc003fek.2_Missense_Mutation_p.V739M	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	739	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TACTCATACACATGACCCACG	0.458										HNSCC(40;0.11)			43	112					0	0	0	0	T	164906404	T	T	164906404	3	4	60	1	0	0	0	0	1	0	0	0	14808	478	17	4	722	4	SLITRK3	3	164906404	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	686	164906404	33116026	60	12156											
MFN1	55669	broad.mit.edu	37	chr3	179095193	179095193	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggttgatgaattttgttCagagtttcatcctaatccag	9	18	8	6	0	2	3	2	2	0	1	4	3	4	3	2	1	0	3	2	1	2	7			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:179095193C>T	uc003fjs.2	+	12	1412	c.1286C>T	c.(1285-1287)TCA>TTA	p.S429L	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.S457L|MFN1_uc010hxc.2_Missense_Mutation_p.S282L	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	429	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			GAATTTTGTTCAGAGTTTCAT	0.264													32	123					0	0	0	0	T	179095193	T	T	179095193	3	4	60	1	0	0	0	0	1	0	0	0	9576	838	29	2	1328	2	MFN1	3	179095193	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	14188789	179095193	18927237	61	12157											
ATP11B	23200	broad.mit.edu	37	chr3	182602582	182602582	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacaggctgcaagaaacagtGactatgcaatagccagattt	15	8	10	8	0	0	3	0	1	0	2	0	4	0	3	1	1	4	3	1	1	5	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:182602582G>C	uc003flb.2	+	22	2808	c.2551G>C	c.(2551-2553)GAC>CAC	p.D851H	ATP11B_uc003flc.2_Missense_Mutation_p.D435H|ATP11B_uc011bqm.1_Missense_Mutation_p.D155H|ATP11B_uc010hxf.1_Missense_Mutation_p.D13H	NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	851	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			AAGAAACAGTGACTATGCAAT	0.318													27	85					0	0	0	0	C	182602582	C	C	182602582	3	2	60	1	0	0	0	0	1	0	0	0	1122	1290	45	2	2637	2	ATP11B	3	182602582	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	3507389	182602582	15419848	62	12158											
FETUB	26998	broad.mit.edu	37	chr3	186358267	186358267	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agaatgggtctgctccttccCctggcactctgcatcctagt	6	12	9	14	0	2	1	0	0	2	1	5	1	5	1	4	2	2	3	4	2	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr3:186358267C>T	uc010hyq.2	+	2	279	c.18C>T	c.(16-18)CCC>CCT	p.P6P	FETUB_uc011brz.1_Intron|FETUB_uc003fqn.2_Silent_p.P6P|FETUB_uc003fqo.2_5'UTR|FETUB_uc010hyr.2_Silent_p.P6P|FETUB_uc010hys.2_5'UTR|FETUB_uc003fqp.3_Silent_p.P6P	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	6						extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		TGCTCCTTCCCCTGGCACTCT	0.597													65	391					0	0	0	0	T	186358267	T	T	186358267	2	4	60	1	0	0	0	0	0	0	0	1	5853	610	22	4		4	FETUB	3	186358267	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	3755685	186358267	11664163	63	12159											
ZNF595	152687	broad.mit.edu	37	chr4	59413	59413	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagaatttgtatagagatGtgatgttggagaactacagg	14	11	13	3	0	0	4	0	1	0	3	0	6	0	4	0	2	3	3	0	2	5	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:59413G>T	uc003fzv.1	+	2	250	c.94G>T	c.(94-96)GTG>TTG	p.V32L	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Missense_Mutation_p.V32L|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	32					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		GTATAGAGATGTGATGTTGGA	0.433													43	546					2.24893e-16	2.76792e-16	1	0	T	59413	T	T	59413	3	4	60	1	0	0	0	0	1	0	0	0	18092	1377	48	4	100	4	ZNF595	4	59413	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08		59413	191094863	64	12160											
KDR	3791	broad.mit.edu	37	chr4	55976627	55976627	+	Frame_Shift_Del	DEL	G	-	-																															ctttgaaatgggattggtaaGgatgacagtgtaatttcctg																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:55976627delG	uc003has.2	-	9	1500	c.1198delC	c.(1198-1200)CTTfs	p.L400fs	KDR_uc003hat.1_Frame_Shift_Del_p.L400fs|KDR_uc011bzx.1_Frame_Shift_Del_p.L400fs	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	400	Ig-like C2-type 4.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GGATTGGTAAGGATGACAGTG	0.423			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			---	---	---								-	55976627	-	-	55976627	7	5	60	1	0	1	0	1	0	0	0	0	8178	1000	35	0	2960	0	KDR	4	55976627	Frame_Shift_Del	DEL	G	TCGA-CN-5363-01A-01D-1434-08	55917214	55976627	135177649	65	12161											
KIAA1211	57482	broad.mit.edu	37	chr4	57182340	57182340	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcagcggggagcgctcgtgGagagaaagagatggagggtg	10	5	21	5	3	0	2	0	0	0	2	1	7	0	5	0	5	3	2	0	5	1	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:57182340G>A	uc003hbk.2	+	8	3063	c.2672G>A	c.(2671-2673)GGA>GAA	p.G891E	KIAA1211_uc010iha.2_Missense_Mutation_p.G884E|KIAA1211_uc011bzz.1_Missense_Mutation_p.G801E|KIAA1211_uc003hbm.1_Missense_Mutation_p.G777E	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	891										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					AGCGCTCGTGGAGAGAAAGAG	0.627													7	35					0	0	0	0	A	57182340	A	A	57182340	3	1	60	1	0	0	0	0	1	0	0	0	8254	1174	41	2	2690	2	KIAA1211	4	57182340	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	1205713	57182340	133971936	66	12162											
SMR3A	26952	broad.mit.edu	37	chr4	71232413	71232413	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatccacctggaccactggCtcctcctcctccaccatgtt	7	11	5	18	0	0	0	0	0	0	0	5	1	5	1	8	2	0	2	8	2	1	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:71232413C>A	uc003hfg.1	+	3	188	c.107C>A	c.(106-108)GCT>GAT	p.A36D	SMR3B_uc011cas.1_Intron	NM_012390	NP_036522	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3	36	Pro-rich.					extracellular region					0		all_hematologic(202;0.196)				GGACCACTGGCTCCTCCTCCT	0.488													46	162					1.19451e-25	1.60053e-25	1	0	A	71232413	A	A	71232413	3	1	60	1	0	0	0	0	1	0	0	0	14875	797	28	4	113	4	SMR3A	4	71232413	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	14050073	71232413	119921863	67	12163											
SMARCAD1	56916	broad.mit.edu	37	chr4	95200121	95200121	+	Frame_Shift_Del	DEL	A	-	-																															atgtcatgatgcagttgaggAaaatggccaatcatccttta																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:95200121delA	uc003htc.3	+	19	2593	c.2338delA	c.(2338-2340)AAAfs	p.K780fs	SMARCAD1_uc003htb.3_Frame_Shift_Del_p.K782fs|SMARCAD1_uc003htd.3_Frame_Shift_Del_p.K782fs|SMARCAD1_uc010ila.2_Frame_Shift_Del_p.K645fs|SMARCAD1_uc011cdw.1_Frame_Shift_Del_p.K350fs	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	780					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		GCAGTTGAGGAAAATGGCCAA	0.338													---	---	---								-	95200121	-	-	95200121	7	5	60	1	0	1	0	1	0	0	0	0	14836	247	9	0	2414	0	SMARCAD1	4	95200121	Frame_Shift_Del	DEL	A	TCGA-CN-5363-01A-01D-1434-08	23967708	95200121	95954155	68	12164											
NHEDC2	133308	broad.mit.edu	37	chr4	103988651	103988651	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatggagggcgtgtaattCattcctgtggatggttctga	7	14	14	6	1	2	1	1	1	1	0	3	3	3	3	1	4	1	3	1	4	1	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:103988651C>A	uc003hwx.3	-	2	929	c.57G>T	c.(55-57)ATG>ATT	p.M19I	NHEDC2_uc003hwy.2_Missense_Mutation_p.M19I|NHEDC2_uc011cew.1_Missense_Mutation_p.M19I|NHEDC2_uc011cex.1_Missense_Mutation_p.M19I|NHEDC2_uc011cey.1_Missense_Mutation_p.M19I	NM_178833	NP_849155	Q86UD5	NHDC2_HUMAN	Na+/H+ exchanger domain containing 2	19					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity				0				OV - Ovarian serous cystadenocarcinoma(123;2.3e-08)		GCGTGTAATTCATTCCTGTGG	0.363													51	144					7.71302e-15	9.16131e-15	1	0	A	103988651	A	A	103988651	3	1	60	1	0	0	0	0	1	0	0	0	10455	826	29	2	1600	2	NHEDC2	4	103988651	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	8788530	103988651	87165625	69	12165											
INTS12	57117	broad.mit.edu	37	chr4	106604207	106604207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggaggtggttttaaaggtaCagtgggcgtagtgctgttat	8	14	16	3	1	0	0	0	0	0	0	0	1	0	1	0	5	2	5	0	5	5	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:106604207C>T	uc003hxw.2	-	8	1330	c.1072G>A	c.(1072-1074)GTA>ATA	p.V358I	INTS12_uc010ilr.2_Missense_Mutation_p.V358I	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	358	Ser-rich.				snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		TTTAAAGGTACAGTGGGCGTA	0.463													78	240					0	0	0	0	T	106604207	T	T	106604207	3	4	60	1	0	0	0	0	1	0	0	0	7816	478	17	4	320	4	INTS12	4	106604207	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	2615556	106604207	84550069	70	12166											
CFI	3426	broad.mit.edu	37	chr4	110667391	110667391	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catatacctttttctcgtccCcagccagaaacgatgcatgt	10	12	6	13	2	1	1	0	0	1	1	3	2	2	1	4	0	4	1	4	0	3	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:110667391C>G	uc003hzr.3	-	11	1624	c.1416G>C	c.(1414-1416)TGG>TGC	p.W472C	CFI_uc003hzq.2_Missense_Mutation_p.W269C|CFI_uc011cft.1_Missense_Mutation_p.W480C|CFI_uc003hzs.3_Missense_Mutation_p.W465C	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	472	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		TTTCTCGTCCCCAGCCAGAAA	0.418													29	89					0	0	0	0	G	110667391	G	G	110667391	3	3	60	1	0	0	0	0	1	0	0	0	3304	624	22	4	347	4	CFI	4	110667391	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	4063184	110667391	80486885	71	12167											
NDST4	64579	broad.mit.edu	37	chr4	115858571	115858571	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaataccccagaccttcttcCaagctgcatacagctgaatg	12	9	7	13	0	1	2	0	1	1	1	2	3	2	2	4	0	5	3	4	0	5	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:115858571C>A	uc003ibu.2	-	5	1989	c.1310G>T	c.(1309-1311)TGG>TTG	p.W437L	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	437	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GACCTTCTTCCAAGCTGCATA	0.483													43	133					8.16277e-20	1.04238e-19	1	0	A	115858571	A	A	115858571	3	1	60	1	0	0	0	0	1	0	0	0	10312	595	21	4	1348	4	NDST4	4	115858571	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	5191180	115858571	75295705	72	12168											
ADAD1	132612	broad.mit.edu	37	chr4	123336765	123336765	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcctgagtgggaagatcaCtgaaaggttaaaattactaa	15	10	11	5	0	1	3	1	2	0	1	1	4	1	4	1	3	1	1	1	3	6	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:123336765C>A	uc003ieo.2	+	11	1713	c.1481C>A	c.(1480-1482)ACT>AAT	p.T494N	ADAD1_uc003iep.2_Missense_Mutation_p.T483N|ADAD1_uc003ieq.2_Missense_Mutation_p.T476N	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	494	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						GGGAAGATCACTGAAAGGTTA	0.323													52	196					3.94638e-17	4.92392e-17	1	0	A	123336765	A	A	123336765	3	1	60	1	0	0	0	0	1	0	0	0	231	565	20	4	1515	4	ADAD1	4	123336765	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	7478194	123336765	67817511	73	12169											
INPP4B	8821	broad.mit.edu	37	chr4	143350367	143350367	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcatttggagtcttctggAtacctataaataataggagc	12	14	9	6	0	3	0	1	0	2	0	3	3	3	3	1	3	2	1	1	3	6	8			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:143350367A>G	uc003iix.3	-	6	690	c.95T>C	c.(94-96)ATC>ACC	p.I32T	INPP4B_uc003iiw.3_Missense_Mutation_p.I32T|INPP4B_uc011chm.1_RNA|INPP4B_uc011cho.1_RNA|INPP4B_uc003iiz.2_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	32	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					AGTCTTCTGGATACCTATAAA	0.274													15	30					0	0	0	0	G	143350367	G	G	143350367	3	3	60	1	0	0	0	0	1	0	0	0	7792	333	12	5	2767	5	INPP4B	4	143350367	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	20013602	143350367	47803909	74	12170											
POU4F2	5458	broad.mit.edu	37	chr4	147561057	147561057	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggatgagagtctgctggcCcgcgccgaggctctggcagc	5	7	16	13	3	2	1	0	1	2	1	2	4	2	2	2	4	2	3	2	4	0	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:147561057C>A	uc003ikv.2	+	2	575	c.327C>A	c.(325-327)GCC>GCA	p.A109A		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	109					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					GTCTGCTGGCCCGCGCCGAGG	0.602													8	26					9.70103e-10	1.10869e-09	1	0	A	147561057	A	A	147561057	2	1	60	1	0	0	0	0	0	0	0	1	12334	610	22	4		4	POU4F2	4	147561057	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	4210690	147561057	43593219	75	12171											
TTC29	83894	broad.mit.edu	37	chr4	147741347	147741347	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctttgaaaattgtttcttGcaattttcacaaattttttc	10	20	5	6	0	2	1	1	1	1	0	3	1	2	1	0	1	1	3	0	1	4	9			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:147741347G>A	uc003ikw.3	-	10	1258	c.1031C>T	c.(1030-1032)GCA>GTA	p.A344V	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Missense_Mutation_p.A370V|TTC29_uc010ipd.1_Missense_Mutation_p.A344V	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	344	TPR 4.						binding				0	all_hematologic(180;0.151)					ATTGTTTCTTGCAATTTTCAC	0.333													8	108					0	0	0	0	A	147741347	A	A	147741347	3	1	60	1	0	0	0	0	1	0	0	0	16764	1319	46	4	412	4	TTC29	4	147741347	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	180290	147741347	43412929	76	12172											
LRAT	9227	broad.mit.edu	37	chr4	155670238	155670238	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacgggcttggtatcatacActacccttcctgcaattttt	8	15	7	11	1	1	0	1	0	0	0	2	0	2	0	2	2	4	4	2	2	5	8	rs140421566	by1000genomes	TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:155670238A>G	uc003iom.1	+	2	970	c.643A>G	c.(643-645)ACT>GCT	p.T215A	LRAT_uc003ion.1_Missense_Mutation_p.T215A	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	215	Helical; (Potential).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	GGTATCATACACTACCCTTCC	0.403													63	276					0	0	0	0	G	155670238	G	G	155670238	3	3	60	1	0	0	0	0	1	0	0	0	8980	159	6	5	649	5	LRAT	4	155670238	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	7928891	155670238	35484038	77	12173											
SORBS2	8470	broad.mit.edu	37	chr4	186544587	186544587	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaatcgagtgtaggaggccgGgcacctgcctttgcaggagc	9	7	15	10	2	0	0	0	0	0	0	1	3	0	2	3	4	3	3	3	4	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:186544587G>T	uc003iyl.2	-	13	2842	c.1984C>A	c.(1984-1986)CCG>ACG	p.P662T	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.P762T|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.P566T|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.P776T|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	662						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TAGGAGGCCGGGCACCTGCCT	0.413													63	128					3.86002e-21	5.04772e-21	1	0	T	186544587	T	T	186544587	3	4	60	1	0	0	0	0	1	0	0	0	14992	1232	43	4	1354	4	SORBS2	4	186544587	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	30874349	186544587	4609689	78	12174											
FRG1	2483	broad.mit.edu	37	chr4	190876258	190876258	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatggacttgttgttgggcgTtcagatgcaattggaccaag	9	12	14	6	1	1	1	1	0	0	1	1	4	1	3	1	3	1	4	1	3	2	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr4:190876258T>C	uc003izs.2	+	5	575	c.384T>C	c.(382-384)CGT>CGC	p.R128R		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	128					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		TTGTTGGGCGTTCAGATGCAA	0.353													4	217					0	0	0	0	C	190876258	C	C	190876258	2	2	60	1	0	0	0	0	0	0	0	1	6080	1712	60	5		5	FRG1	4	190876258	Silent	SNP	T	TCGA-CN-5363-01A-01D-1434-08	4331671	190876258	278018	79	12175											
SLC12A7	10723	broad.mit.edu	37	chr5	1089145	1089145	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggactccaggacaccagcCacccccacgatccacgtcag	12	3	8	18	2	1	0	1	0	0	0	3	3	3	2	6	2	1	0	6	2	1	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:1089145C>T	uc003jbu.2	-	4	507	c.441G>A	c.(439-441)GTG>GTA	p.V147V		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	147	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GGACACCAGCCACCCCCACGA	0.652													36	124					0	0	0	0	T	1089145	T	T	1089145	2	4	60	1	0	0	0	0	0	0	0	1	14453	581	21	4		4	SLC12A7	5	1089145	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08		1089145	179826115	80	12176											
DNAH5	1767	broad.mit.edu	37	chr5	13716599	13716599	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttctgaagttgacaaacctgGatatactgaagatagttatc	14	13	8	6	0	1	4	0	3	1	1	2	5	1	5	1	1	2	2	1	1	7	6	rs113914833		TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:13716599G>T	uc003jfd.2	-	74	12948	c.12906C>A	c.(12904-12906)ATC>ATA	p.I4302I	DNAH5_uc003jfc.2_Silent_p.I470I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4302					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GACAAACCTGGATATACTGAA	0.333									Kartagener_syndrome				19	46					3.8784e-16	4.75192e-16	1	0	T	13716599	T	T	13716599	2	4	60	1	0	0	0	0	0	0	0	1	4626	1164	41	2		2	DNAH5	5	13716599	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	12627454	13716599	167198661	81	12177											
DNAH5	1767	broad.mit.edu	37	chr5	13841180	13841180	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttttttatcaaacttggcAtttctaagggcttcttctga	9	19	6	7	0	4	1	1	1	3	0	4	1	4	1	0	2	1	2	0	2	3	9			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:13841180A>G	uc003jfd.2	-	34	5586	c.5544T>C	c.(5542-5544)AAT>AAC	p.N1848N		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1848	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CAAACTTGGCATTTCTAAGGG	0.388									Kartagener_syndrome				38	150					0	0	0	0	G	13841180	G	G	13841180	2	3	60	1	0	0	0	0	0	0	0	1	4626	214	8	5		5	DNAH5	5	13841180	Silent	SNP	A	TCGA-CN-5363-01A-01D-1434-08	124581	13841180	167074080	82	12178											
HCN1	348980	broad.mit.edu	37	chr5	45353210	45353210	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataaatcttacctctctcaGaggatcattgagttcattga	13	14	6	8	0	5	3	3	2	2	1	6	4	5	4	1	1	1	1	1	1	4	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:45353210G>C	uc003jok.2	-	5	1394	c.1369C>G	c.(1369-1371)CTG>GTG	p.L457V		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	457	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ACCTCTCTCAGAGGATCATTG	0.348													31	90					0	0	0	0	C	45353210	C	C	45353210	3	2	60	1	0	0	0	0	1	0	0	0	7035	933	33	2	1319	2	HCN1	5	45353210	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	31512030	45353210	135562050	83	12179											
NDUFS4	4724	broad.mit.edu	37	chr5	52942221	52942221	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgatgggaaaatcctttgatGggttgggcatcaacgtgagt	10	11	14	6	2	1	2	1	2	0	0	2	4	2	3	1	3	1	2	1	3	3	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:52942221G>A	uc003jpe.2	+	3	364	c.336G>A	c.(334-336)ATG>ATA	p.M112I		NM_002495	NP_002486	O43181	NDUS4_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 4	112					brain development|cAMP-mediated signaling|mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|positive regulation of fibroblast proliferation|reactive oxygen species metabolic process|regulation of protein phosphorylation|response to cAMP|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)	1		Lung NSC(810;8.27e-05)|Breast(144;0.0848)			NADH(DB00157)	ATCCTTTGATGGGTTGGGCAT	0.353													13	104					0	0	0	0	A	52942221	A	A	52942221	3	1	60	1	0	0	0	0	1	0	0	0	10348	1348	47	4	346	4	NDUFS4	5	52942221	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	7589011	52942221	127973039	84	12180											
IL6ST	3572	broad.mit.edu	37	chr5	55250717	55250717	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctttatctgataacacacaCcactcaagtatatatttctt	13	15	3	10	0	3	1	1	1	2	0	3	1	3	1	1	0	1	2	1	0	6	8			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:55250717C>A	uc003jqq.2	-	11	1626	c.1371G>T	c.(1369-1371)TGG>TGT	p.W457C	IL6ST_uc010iwb.2_Intron|IL6ST_uc010iwc.2_Intron|IL6ST_uc010iwd.2_Intron|IL6ST_uc011cqk.1_Missense_Mutation_p.W168C|IL6ST_uc003jqr.2_3'UTR	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	457	Extracellular (Potential).|Fibronectin type-III 4.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				ATAACACACACCACTCAAGTA	0.423			O		hepatocellular ca								46	320					1.35964e-18	1.7201e-18	1	0	A	55250717	A	A	55250717	3	1	60	1	0	0	0	0	1	0	0	0	7742	508	18	4	1413	4	IL6ST	5	55250717	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	2308496	55250717	125664543	85	12181											
ERBB2IP	55914	broad.mit.edu	37	chr5	65370963	65370963	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcatccctctagagaacaaCtaattgattacttgatgctg	12	12	8	9	0	1	3	0	2	1	1	2	4	2	3	1	1	4	2	1	1	5	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:65370963C>G	uc003juk.1	+	23	4176	c.3868C>G	c.(3868-3870)CTA>GTA	p.L1290V	ERBB2IP_uc003jui.1_Missense_Mutation_p.L1249V|ERBB2IP_uc003juj.1_Intron|ERBB2IP_uc011cqx.1_Missense_Mutation_p.L1297V|ERBB2IP_uc011cqy.1_Missense_Mutation_p.L1249V|ERBB2IP_uc011cqz.1_Missense_Mutation_p.L488V|ERBB2IP_uc010iwx.1_Missense_Mutation_p.L1293V|ERBB2IP_uc003jul.1_Missense_Mutation_p.L1245V	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	1290					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TAGAGAACAACTAATTGATTA	0.488													60	184					0	0	0	0	G	65370963	G	G	65370963	3	3	60	1	0	0	0	0	1	0	0	0	5231	564	20	4	3823	4	ERBB2IP	5	65370963	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	10120246	65370963	115544297	86	12182											
NAIP	4671	broad.mit.edu	37	chr5	70308192	70308192	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgtaaagacaaagccaGcctctgagagcacacaaggg	15	5	10	11	0	1	2	0	1	1	2	1	3	1	2	3	1	4	2	3	1	5	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:70308192G>C	uc003kar.1	-	4	1269	c.551C>G	c.(550-552)GCT>GGT	p.A184G	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Missense_Mutation_p.A184G|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein isoform	184	BIR 2.				anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		GACAAAGCCAGCCTCTGAGAG	0.413													22	76					0	0	0	0	C	70308192	C	C	70308192	3	2	60	1	0	0	0	0	1	0	0	0	10200	971	34	4	3716	4	NAIP	5	70308192	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	4937229	70308192	110607068	87	12183											
ENC1	8507	broad.mit.edu	37	chr5	73931933	73931933	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggatgtcttgaaactccagCatgtcaccagcttccaggag	10	9	10	12	1	2	1	1	1	1	0	4	3	4	3	3	2	3	2	3	2	1	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:73931933C>A	uc003kdc.3	-	2	1509	c.378G>T	c.(376-378)ATG>ATT	p.M126I	ENC1_uc011css.1_Missense_Mutation_p.M53I	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	126				INEENAESLLEAGDMLEFQ -> HQLEGKCRNSLLGSLVTC WSFK (in Ref. 1).	nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		GAAACTCCAGCATGTCACCAG	0.532													25	142					1.42536e-11	1.64278e-11	1	0	A	73931933	A	A	73931933	3	1	60	1	0	0	0	0	1	0	0	0	5137	710	25	4	1395	4	ENC1	5	73931933	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	3623741	73931933	106983327	88	12184											
AP3B1	8546	broad.mit.edu	37	chr5	77521392	77521392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttatctttcagaagtttttCaattacttcaattaacattt	12	21	2	6	0	4	1	3	0	1	1	4	1	4	1	0	0	2	1	0	0	6	9	rs149521661		TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:77521392C>T	uc003kfj.2	-	6	702	c.577G>A	c.(577-579)GAA>AAA	p.E193K		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	193					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		AGAAGTTTTTCAATTACTTCA	0.254									Hermansky-Pudlak_syndrome				13	41					0	0	0	0	T	77521392	T	T	77521392	3	4	60	1	0	0	0	0	1	0	0	0	744	835	29	2	2795	2	AP3B1	5	77521392	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	3589459	77521392	103393868	89	12185											
TTC37	9652	broad.mit.edu	37	chr5	94852062	94852062	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcaacatatttacctcaaTgttttcatttgtgaggtata	12	16	7	6	0	2	1	2	1	0	0	2	1	2	1	1	2	2	3	1	2	6	8			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:94852062T>C	uc003klb.2	-	25	2899	c.2629A>G	c.(2629-2631)ATT>GTT	p.I877V		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	877	TPR 15.		Missing (found in a patient with THE syndrome).				binding			ovary(3)|pancreas(1)	4						TTTACCTCAATGTTTTCATTT	0.328													14	80					0	0	0	0	C	94852062	C	C	94852062	3	2	60	1	0	0	0	0	1	0	0	0	16773	1464	51	5	2141	5	TTC37	5	94852062	Missense_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	17330670	94852062	86063198	90	12186											
YTHDC2	64848	broad.mit.edu	37	chr5	112917312	112917312	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccaaggcctatgtcttcaGaagagcttcctttggcctca	8	11	10	12	0	3	2	2	0	1	2	4	2	4	2	4	3	1	1	4	3	3	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:112917312G>T	uc003kqn.2	+	25	3736	c.3553G>T	c.(3553-3555)GAA>TAA	p.E1185*		NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1185							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TATGTCTTCAGAAGAGCTTCC	0.408													23	56					1.10923e-09	1.25713e-09	1	0	T	112917312	T	T	112917312	4	4	60	1	0	0	0	0	0	1	0	0	17565	943	33	2	3651	2	YTHDC2	5	112917312	Nonsense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	18065250	112917312	67997948	91	12187											
KCNN2	3781	broad.mit.edu	37	chr5	113829151	113829151	+	Frame_Shift_Del	DEL	T	-	-																															ctgaatgaccaagcaaacacTttggtggacttggcaaaggt																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:113829151delT	uc003kqo.2	+	7	1891	c.1434delT	c.(1432-1434)ACTfs	p.T478fs	KCNN2_uc003kqp.2_Frame_Shift_Del_p.T130fs|KCNN2_uc010jcg.2_RNA|uc003kqr.1_Intron	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	478	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		AAGCAAACACTTTGGTGGACT	0.403													---	---	---								-	113829151	-	-	113829151	7	5	60	1	0	1	0	1	0	0	0	0	8118	1596	56	0	1460	0	KCNN2	5	113829151	Frame_Shift_Del	DEL	T	TCGA-CN-5363-01A-01D-1434-08	911839	113829151	67086109	92	12188											
C5orf48	389320	broad.mit.edu	37	chr5	125971893	125971893	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcctctctccagataccaaaGcactgtgatttcccatggct	9	11	7	14	0	1	2	0	1	1	1	4	2	3	2	4	1	2	2	4	1	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:125971893G>A	uc003kub.1	+	3	378	c.365G>A	c.(364-366)AGC>AAC	p.S122N		NM_207408	NP_997291	Q6ZNM6	CE048_HUMAN	hypothetical protein LOC389320	122										ovary(1)	1						AGATACCAAAGCACTGTGATT	0.403													25	143					0	0	0	0	A	125971893	A	A	125971893	3	1	60	1	0	0	0	0	1	0	0	0	2316	971	34	4	375	4	C5orf48	5	125971893	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	12142742	125971893	54943367	93	12189											
PCDHA7	56141	broad.mit.edu	37	chr5	140214169	140214169	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcgcctgttccgggcggtGtgcaaattccgtggggatct	4	10	15	12	5	1	0	0	0	1	0	3	1	3	1	4	4	1	2	4	4	1	2	rs139714335		TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:140214169G>T	uc003lhq.2	+	1	201	c.201G>T	c.(199-201)GTG>GTT	p.V67V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.V67V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	67	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCGGGCGGTGTGCAAATTCC	0.632													50	278					3.19069e-20	4.11311e-20	1	0	T	140214169	T	T	140214169	2	4	60	1	0	0	0	0	0	0	0	1	11583	1364	48	4		4	PCDHA7	5	140214169	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	14242276	140214169	40701091	94	12190											
PCDHA12	56137	broad.mit.edu	37	chr5	140256976	140256976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacacgcatcctggatgaggCggacgctccgcgccaccgcc	7	4	13	17	6	0	1	0	1	0	0	2	4	2	3	5	3	0	2	5	3	0	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:140256976C>T	uc003lic.2	+	1	2046	c.1919C>T	c.(1918-1920)GCG>GTG	p.A640V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.A640V	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	640	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGATGAGGCGGACGCTCCG	0.687													19	54					0	0	0	0	T	140256976	T	T	140256976	3	4	60	1	0	0	0	0	1	0	0	0	11576	768	27	1	1921	1	PCDHA12	5	140256976	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	42807	140256976	40658284	95	12191											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720647	140720647	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggccgcggtctcctgcgtCttcctggccttcgtcatcgt	1	13	12	15	5	3	0	1	0	2	0	7	0	4	0	4	3	1	0	4	3	0	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:140720647C>T	uc003ljk.1	+	1	2294	c.2109C>T	c.(2107-2109)GTC>GTT	p.V703V	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Silent_p.V703V|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	703	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTCCTGCGTCTTCCTGGCCT	0.652													60	165					0	0	0	0	T	140720647	T	T	140720647	2	4	60	1	0	0	0	0	0	0	0	1	11608	900	32	2		2	PCDHGA2	5	140720647	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	463671	140720647	40194613	96	12192											
PCDHGB5	56101	broad.mit.edu	37	chr5	140777700	140777700	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggagagcaagagggatgggGagcggcgccggggagctggg	9	2	24	6	3	0	2	0	0	0	2	0	6	0	5	1	8	3	2	1	8	1	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:140777700G>A	uc003lkf.1	+	1	6	c.6G>A	c.(4-6)GGG>GGA	p.G2G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.G2G	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	2					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGGATGGGGAGCGGCGCCG	0.577											OREG0016860	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	13					0	0	0	0	A	140777700	A	A	140777700	2	1	60	1	0	0	0	0	0	0	0	1	11620	1161	41	2		2	PCDHGB5	5	140777700	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	57053	140777700	40137560	97	12193											
PCDH1	5097	broad.mit.edu	37	chr5	141233630	141233630	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggtagatctcgcgcttggCcgtctgggcagatgccggtg	5	9	16	11	4	2	2	0	0	2	2	3	2	2	2	2	4	1	3	2	4	1	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr5:141233630C>T	uc003llp.2	-	5	3808	c.3691G>A	c.(3691-3693)GCC>ACC	p.A1231T		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TCGCGCTTGGCCGTCTGGGCA	0.672													3	26					0	0	0	0	T	141233630	T	T	141233630	3	4	60	1	0	0	0	0	1	0	0	0	11560	739	26	4	26	4	PCDH1	5	141233630	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	455930	141233630	39681630	98	12194											
ZNF184	7738	broad.mit.edu	37	chr6	27424701	27424701	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtttagaaacttggagtcCtgttcattagggaaaaaaag	15	11	11	4	0	1	1	1	0	0	1	2	3	2	3	1	3	1	2	1	3	6	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:27424701C>T	uc003njj.2	-	4	1014	c.203_splice	c.e4-1	p.G68_splice	ZNF184_uc010jqv.2_Splice_Site_p.G68_splice|ZNF184_uc003nji.2_Splice_Site_p.G68_splice	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACTTGGAGTCCTGTTCATTAG	0.408													56	124					0	0	0	0	T	27424701	T	T	27424701	5	4	60	1	0	0	0	0	0	0	1	0	17818	695	24	4	2061	4	ZNF184	6	27424701	Splice_Site	SNP	C	TCGA-CN-5363-01A-01D-1434-08		27424701	143690366	99	12195											
GPX6	257202	broad.mit.edu	37	chr6	28473519	28473519	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgttctttttctccattCacatcccctttctcaaagag	7	18	3	13	0	5	1	2	0	4	1	8	1	6	1	3	0	0	1	3	0	1	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:28473519C>A	uc011dlj.1	-	5	470	c.420G>T	c.(418-420)GTG>GTT	p.V140V	GPX6_uc010jrg.1_Intron	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	140					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	TTTCTCCATTCACATCCCCTT	0.453													12	80					7.03913e-09	7.8469e-09	1	0	A	28473519	A	A	28473519	2	1	60	1	0	0	0	0	0	0	0	1	6783	813	29	2		2	GPX6	6	28473519	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	1048818	28473519	142641548	100	12196											
CCHCR1	54535	broad.mit.edu	37	chr6	31110480	31110480	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcctgcaggtcatcgagcagGacagagagggaccctgggaa	11	5	15	10	1	1	1	1	0	0	1	3	6	2	4	2	4	2	2	2	4	1	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:31110480G>A	uc003nsr.3	-	18	2361	c.2238C>T	c.(2236-2238)GTC>GTT	p.V746V	CCHCR1_uc011dne.1_Silent_p.V732V|CCHCR1_uc003nsq.3_Silent_p.V799V|CCHCR1_uc003nsp.3_Silent_p.V835V	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	746					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						CATCGAGCAGGACAGAGAGGG	0.537													42	109					0	0	0	0	A	31110480	A	A	31110480	2	1	60	1	0	0	0	0	0	0	0	1	2890	1161	41	2		2	CCHCR1	6	31110480	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	2636961	31110480	140004587	101	12197											
TAP2	6891	broad.mit.edu	37	chr6	32797314	32797314	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttcccttctcccctacatCtgaggaaatcagagaaattc	11	11	6	13	0	3	2	1	1	2	1	6	4	4	3	3	1	1	1	3	1	3	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:32797314C>G	uc003occ.2	-	10	1827	c.1796_splice	c.e10-1	p.D599_splice	TAP2_uc011dqf.1_Splice_Site_p.D599_splice|TAP2_uc003ocb.1_Splice_Site_p.D599_splice|TAP2_uc003ocd.2_Splice_Site_p.D599_splice	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family						antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						TCCCCTACATCTGAGGAAATC	0.557													11	55					0	0	0	0	G	32797314	G	G	32797314	5	3	60	1	0	0	0	0	0	0	1	0	15617	927	32	2	358	2	TAP2	6	32797314	Splice_Site	SNP	C	TCGA-CN-5363-01A-01D-1434-08	1686834	32797314	138317753	102	12198											
TRERF1	55809	broad.mit.edu	37	chr6	42231259	42231259	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggaggcggaggcggaggCggcagtggtggctggggctg	4	4	26	7	4	0	0	0	0	0	0	0	3	0	3	0	12	0	3	0	12	0	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:42231259C>A	uc003osd.2	-	8	2246	c.1683G>T	c.(1681-1683)CCG>CCT	p.P561P	TRERF1_uc011duq.1_Intron|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Silent_p.P561P	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	561	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			gaggcggaggcggcagtggtg	0.378													12	36					4.26978e-12	4.94204e-12	1	0	A	42231259	A	A	42231259	2	1	60	1	0	0	0	0	0	0	0	1	16542	755	27	3		3	TRERF1	6	42231259	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	9433945	42231259	128883808	103	12199											
ZNF318	24149	broad.mit.edu	37	chr6	43306786	43306786	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccatttccctagggccacCagagtttttgcaatgggctt	8	12	10	11	0	0	1	0	0	0	1	1	2	1	1	4	2	1	3	4	2	2	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:43306786C>A	uc003oux.2	-	10	5028	c.4950G>T	c.(4948-4950)CTG>CTT	p.L1650L	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1650					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTAGGGCCACCAGAGTTTTTG	0.493													80	208					1.43161e-34	1.9373e-34	1	0	A	43306786	A	A	43306786	2	1	60	1	0	0	0	0	0	0	0	1	17903	581	21	4		4	ZNF318	6	43306786	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	1075527	43306786	127808281	104	12200											
CDC5L	988	broad.mit.edu	37	chr6	44413419	44413419	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtcacatgacgacagaaGccaagagggctgcaaagatg	14	4	15	8	1	1	4	1	1	0	3	1	5	1	4	1	3	2	2	1	3	3	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:44413419G>T	uc003oxl.2	+	15	2378	c.2119G>T	c.(2119-2121)GCC>TCC	p.A707S		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	707	Interaction with PLRG1.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GACGACAGAAGCCAAGAGGGC	0.443													6	53					3.59834e-05	3.86857e-05	1	0	T	44413419	T	T	44413419	3	4	60	1	0	0	0	0	1	0	0	0	3097	971	34	4	2177	4	CDC5L	6	44413419	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	1106633	44413419	126701648	105	12201											
RCAN2	10231	broad.mit.edu	37	chr6	46190997	46190997	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcacacgtgcacgacgacacTtggggtggactcagtccctg	8	7	13	13	3	1	0	1	0	0	0	2	3	2	1	1	3	1	2	1	3	0	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:46190997T>A	uc003oyb.1	-	4	790	c.475A>T	c.(475-477)AGT>TGT	p.S159C	RCAN2_uc003oyc.1_Missense_Mutation_p.S205C|RCAN2_uc003oyd.1_Missense_Mutation_p.S205C	NM_005822	NP_005813	Q14206	RCAN2_HUMAN	Down syndrome critical region gene 1-like 1	159					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding				0						ACGACGACACTTGGGGTGGAC	0.512													38	216					0	0	0	0	A	46190997	A	A	46190997	3	1	60	1	0	0	0	0	1	0	0	0	13234	1609	56	5	122	5	RCAN2	6	46190997	Missense_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	1777578	46190997	124924070	106	12202											
ZNF451	26036	broad.mit.edu	37	chr6	57015556	57015556	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagatttggattacctgcGaaccatgactcatatagtct	11	13	7	10	1	2	2	1	1	1	1	3	4	3	3	3	1	3	0	3	1	4	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:57015556G>T	uc003pdm.1	+	11	2872	c.2648G>T	c.(2647-2649)CGA>CTA	p.R883L	ZNF451_uc003pdl.2_Missense_Mutation_p.R883L|ZNF451_uc003pdn.1_Intron|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.R883L	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	883					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GATTACCTGCGAACCATGACT	0.358													58	174					2.40265e-35	3.2676e-35	1	0	T	57015556	T	T	57015556	3	4	60	1	0	0	0	0	1	0	0	0	17989	1058	37	3	2690	3	ZNF451	6	57015556	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	10824559	57015556	114099511	107	12203											
HTR1B	3351	broad.mit.edu	37	chr6	78172872	78172872	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggcgatcaggtagttagcCggggtgtgcagtttccgggt	6	10	18	7	3	1	0	1	0	0	0	2	2	2	0	2	5	2	4	2	5	2	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:78172872C>A	uc003pil.1	-	1	249	c.249G>T	c.(247-249)CCG>CCT	p.P83P		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	83	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	GGTAGTTAGCCGGGGTGTGCA	0.582													48	198					1.23713e-20	1.60238e-20	1	0	A	78172872	A	A	78172872	2	1	60	1	0	0	0	0	0	0	0	1	7476	639	23	3		3	HTR1B	6	78172872	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	21157316	78172872	92942195	108	12204											
C6orf165	154313	broad.mit.edu	37	chr6	88140765	88140765	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttagaagatagagtaaatGtggcagatttcagaaaacta	17	12	9	3	0	1	5	1	0	0	5	1	5	1	5	0	1	1	2	0	1	8	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:88140765G>A	uc003plv.2	+	10	1266	c.1174G>A	c.(1174-1176)GTG>ATG	p.V392M	C6orf165_uc003plw.2_Missense_Mutation_p.V204M|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Missense_Mutation_p.V392M	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	392										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TAGAGTAAATGTGGCAGATTT	0.328													16	49					0	0	0	0	A	88140765	A	A	88140765	3	1	60	1	0	0	0	0	1	0	0	0	2351	1377	48	4	1208	4	C6orf165	6	88140765	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	9967893	88140765	82974302	109	12205											
UBE2J1	51465	broad.mit.edu	37	chr6	90052081	90052081	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtggtttcatgggatactCtggtggcagtactatccgcc	6	13	13	9	1	2	0	1	0	1	0	3	1	3	1	2	5	2	3	2	5	3	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:90052081C>G	uc010kcb.2	-	4	372	c.199G>C	c.(199-201)GAG>CAG	p.E67Q	UBE2J1_uc003pnc.2_Missense_Mutation_p.E67Q	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	67	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		ATGGGATACTCTGGTGGCAGT	0.448													16	76					0	0	0	0	G	90052081	G	G	90052081	3	3	60	1	0	0	0	0	1	0	0	0	16928	922	32	2	781	2	UBE2J1	6	90052081	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	1911316	90052081	81062986	110	12206											
EPB41L2	2037	broad.mit.edu	37	chr6	131247798	131247798	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagtagtctttctccaagaGattgaggtgttcacacactt	12	13	8	8	0	3	2	1	1	2	1	4	3	3	2	1	1	0	2	1	1	3	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:131247798G>C	uc003qch.2	-	4	939	c.757C>G	c.(757-759)CTC>GTC	p.L253V	EPB41L2_uc003qcg.1_Missense_Mutation_p.L253V|EPB41L2_uc011eby.1_Missense_Mutation_p.L253V|EPB41L2_uc003qci.2_Missense_Mutation_p.L253V|EPB41L2_uc010kfk.2_Missense_Mutation_p.L253V|EPB41L2_uc010kfl.1_Missense_Mutation_p.L253V	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	253	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TTCTCCAAGAGATTGAGGTGT	0.323													74	128					0	0	0	0	C	131247798	C	C	131247798	3	2	60	1	0	0	0	0	1	0	0	0	5177	942	33	2	2324	2	EPB41L2	6	131247798	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	41195717	131247798	39867269	111	12207											
SHPRH	257218	broad.mit.edu	37	chr6	146267451	146267451	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcctccaaaataatgtgaCggaataaaataattcaccac	17	11	4	9	1	1	1	1	1	0	0	3	2	3	2	3	1	0	0	3	1	7	5	rs140562619	by1000genomes	TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:146267451C>T	uc003qlf.2	-	7	1638	c.1239G>A	c.(1237-1239)CCG>CCA	p.P413P	SHPRH_uc003qld.2_Silent_p.P413P|SHPRH_uc003qle.2_Silent_p.P413P|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Silent_p.P302P	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	413					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		AATAATGTGACGGAATAAAAT	0.323													17	49					0	0	0	0	T	146267451	T	T	146267451	2	4	60	1	0	0	0	0	0	0	0	1	14356	523	19	1		1	SHPRH	6	146267451	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	15019653	146267451	24847616	112	12208											
SYNE1	23345	broad.mit.edu	37	chr6	152555059	152555059	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtactcagaacagatgAtttcagggaagattgggcat	13	10	11	7	0	2	4	2	1	0	3	3	5	3	5	1	2	2	2	1	2	3	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:152555059A>G	uc010kiw.2	-	112	21171	c.20569T>C	c.(20569-20571)TCA>CCA	p.S6857P	SYNE1_uc010kiv.2_Missense_Mutation_p.S1381P|SYNE1_uc003qos.3_Missense_Mutation_p.S1381P|SYNE1_uc003qot.3_Missense_Mutation_p.S6786P|SYNE1_uc003qou.3_Missense_Mutation_p.S6857P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6857	Spectrin 21.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGAACAGATGATTTCAGGGAA	0.438										HNSCC(10;0.0054)			4	86					0	0	0	0	G	152555059	G	G	152555059	3	3	60	1	0	0	0	0	1	0	0	0	15511	333	12	5	6037	5	SYNE1	6	152555059	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	6287608	152555059	18560008	113	12209											
NOX3	50508	broad.mit.edu	37	chr6	155728305	155728305	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcttgaactcattgttccaGttgggcctcccatagaaggt	8	13	10	10	0	1	2	1	1	0	1	3	2	3	2	3	2	2	3	3	2	3	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:155728305G>T	uc003qqm.2	-	12	1642	c.1539C>A	c.(1537-1539)AAC>AAA	p.N513K		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	513	Cytoplasmic (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CATTGTTCCAGTTGGGCCTCC	0.478													25	134					5.45024e-15	6.53068e-15	1	0	T	155728305	T	T	155728305	3	4	60	1	0	0	0	0	1	0	0	0	10611	1020	36	4	175	4	NOX3	6	155728305	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	3173246	155728305	15386762	114	12210											
MAP3K4	4216	broad.mit.edu	37	chr6	161519401	161519401	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttgctgccagtcggcccAgcccctctggtggtgactct	3	11	12	15	1	2	1	0	1	2	0	3	1	2	1	4	3	3	2	4	3	0	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr6:161519401A>T	uc003qtn.2	+	17	3758	c.3616A>T	c.(3616-3618)AGC>TGC	p.S1206C	MAP3K4_uc010kkc.1_Missense_Mutation_p.S1202C|MAP3K4_uc003qto.2_Intron|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.S659C|MAP3K4_uc003qtp.2_Intron|MAP3K4_uc003qtq.2_5'Flank	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1206					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CAGTCGGCCCAGCCCCTCTGG	0.498													21	128					0	0	0	0	T	161519401	T	T	161519401	3	4	60	1	0	0	0	0	1	0	0	0	9305	188	7	5	3682	5	MAP3K4	6	161519401	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	5791096	161519401	9595666	115	12211											
SUN3	256979	broad.mit.edu	37	chr7	48046766	48046766	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcctcatccaggacctctGtgtggtccgggtcctccaca	6	10	10	15	1	2	0	1	0	1	0	6	1	6	1	6	3	1	0	6	3	1	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:48046766G>T	uc003tof.2	-	6	585	c.488C>A	c.(487-489)ACA>AAA	p.T163K	SUN3_uc010kyq.2_Missense_Mutation_p.T63K|SUN3_uc003tog.2_Missense_Mutation_p.T163K|SUN3_uc011kcf.1_Missense_Mutation_p.T151K	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	163						integral to membrane				central_nervous_system(1)	1						CAGGACCTCTGTGTGGTCCGG	0.552													26	75					5.45727e-16	6.6564e-16	1	0	T	48046766	T	T	48046766	3	4	60	1	0	0	0	0	1	0	0	0	15459	1377	48	4	609	4	SUN3	7	48046766	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08		48046766	111091897	116	12212											
SEPT14	346288	broad.mit.edu	37	chr7	55874869	55874869	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cattcatagtgctgagtgtgGgttttttcttttagattttc	6	21	9	5	0	2	2	1	1	1	1	3	2	2	2	0	1	1	2	0	1	2	9			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:55874869G>A	uc003tqz.2	-	8	1017	c.900C>T	c.(898-900)ACC>ACT	p.T300T		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	300					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GCTGAGTGTGGGTTTTTTCTT	0.348													42	126					0	0	0	0	A	55874869	A	A	55874869	2	1	60	1	0	0	0	0	0	0	0	1	14128	1219	43	4		4	SEPT14	7	55874869	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	7828103	55874869	103263794	117	12213											
WBSCR17	64409	broad.mit.edu	37	chr7	71177039	71177039	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaagggcacgggacgctgcCtggaggtggagaaccggggc	9	3	19	10	3	0	1	0	0	0	1	0	4	0	3	2	7	2	2	2	7	2	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:71177039C>A	uc003tvy.2	+	11	1705	c.1705C>A	c.(1705-1707)CTG>ATG	p.L569M	WBSCR17_uc003tvz.2_Missense_Mutation_p.L268M	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	569	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGGACGCTGCCTGGAGGTGGA	0.463													55	193					1.80625e-27	2.43218e-27	1	0	A	71177039	A	A	71177039	3	1	60	1	0	0	0	0	1	0	0	0	17332	680	24	4	1747	4	WBSCR17	7	71177039	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	15302170	71177039	87961624	118	12214											
PCLO	27445	broad.mit.edu	37	chr7	82579984	82579984	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgaatcttttgctcctccAgctgctggtgaagctgttgt	5	14	11	11	1	1	1	0	1	1	0	3	2	3	1	3	1	4	5	3	1	2	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:82579984A>G	uc003uhx.2	-	6	10209	c.9920T>C	c.(9919-9921)CTG>CCG	p.L3307P	PCLO_uc003uhv.2_Missense_Mutation_p.L3307P|PCLO_uc010lec.2_Missense_Mutation_p.L272P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3238	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTGCTCCTCCAGCTGCTGGTG	0.502													40	166					0	0	0	0	G	82579984	G	G	82579984	3	3	60	1	0	0	0	0	1	0	0	0	11637	188	7	5	5605	5	PCLO	7	82579984	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	11402945	82579984	76558679	119	12215											
C7orf51	222950	broad.mit.edu	37	chr7	100084710	100084710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacagaggacagcagcacccGaagaccccctgccaagcccc	12	1	9	19	1	0	2	0	0	0	2	0	4	0	3	6	1	4	2	6	1	2	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:100084710G>A	uc003uvd.1	+	3	494	c.335G>A	c.(334-336)CGA>CAA	p.R112Q	C7orf51_uc003uve.1_5'Flank	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	112										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGCAGCACCCGAAGACCCCCT	0.701													22	45					0	0	0	0	A	100084710	A	A	100084710	3	1	60	1	0	0	0	0	1	0	0	0	2411	1058	37	1	341	1	C7orf51	7	100084710	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	17504726	100084710	59053953	120	12216											
MOGAT3	346606	broad.mit.edu	37	chr7	100839228	100839228	+	Nonstop_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgaaaggccgcggccaggccTagatgaaggtgaggcaggtg	10	4	18	9	3	0	3	0	2	0	1	0	4	0	3	3	6	0	1	3	6	3	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:100839228T>A	uc003uyc.2	-	7	1192	c.1025A>T	c.(1024-1026)TAG>TTG	p.*342L	MOGAT3_uc010lhr.2_Silent_p.L274L	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	342					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					CGGCCAGGCCTAGATGAAGGT	0.577													27	123					0	0	0	0	A	100839228	A	A	100839228	4	1	60	1	0	0	0	0	0	0	0	0	9749	1535	53	5	4	5	MOGAT3	7	100839228	Nonstop_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	754518	100839228	58299435	121	12217											
CUX1	1523	broad.mit.edu	37	chr7	101839913	101839913	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgtttgcccttccttgtaGggtcagccaggaggaaaggg	7	11	14	9	0	2	0	1	0	1	0	3	2	3	2	3	4	2	2	3	4	2	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:101839913G>A	uc003uyx.3	+	15	1261	c.1223_splice	c.e15-1	p.G408_splice	CUX1_uc003uys.3_Splice_Site_p.G419_splice|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a						negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CTTCCTTGTAGGGTCAGCCAG	0.552													35	135					0	0	0	0	A	101839913	A	A	101839913	5	1	60	1	0	0	0	0	0	0	1	0	4081	1014	35	4	1347	4	CUX1	7	101839913	Splice_Site	SNP	G	TCGA-CN-5363-01A-01D-1434-08	1000685	101839913	57298750	122	12218											
CTTNBP2	83992	broad.mit.edu	37	chr7	117407111	117407111	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataagctctgaacatcactcActcagattctccagcaaatg	14	10	5	12	0	5	2	3	1	2	1	6	2	5	2	1	0	3	2	1	0	3	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:117407111A>C	uc003vjf.2	-	9	2988	c.2896_splice	c.e9+1	p.N966_splice		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2											ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		AACATCACTCACTCAGATTCT	0.458													28	108					0	0	0	0	C	117407111	C	C	117407111	5	2	60	1	0	0	0	0	0	0	1	0	4062	173	6	5	2153	5	CTTNBP2	7	117407111	Splice_Site	SNP	A	TCGA-CN-5363-01A-01D-1434-08	15567198	117407111	41731552	123	12219											
PTPRZ1	5803	broad.mit.edu	37	chr7	121699858	121699858	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctctgacaacccttatgcaCcaactagaaaaagaaaattc	17	8	5	11	0	1	3	0	1	1	2	2	3	1	3	2	0	3	2	2	0	8	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:121699858C>T	uc003vjy.2	+	29	7118	c.6723C>T	c.(6721-6723)CAC>CAT	p.H2241H	PTPRZ1_uc003vjz.2_Silent_p.H1374H|PTPRZ1_uc011knt.1_Silent_p.H831H	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	2241	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CCCTTATGCACCAACTAGAAA	0.428													52	148					0	0	0	0	T	121699858	T	T	121699858	2	4	60	1	0	0	0	0	0	0	0	1	12879	506	18	4		4	PTPRZ1	7	121699858	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	4292747	121699858	37438805	124	12220											
CALD1	800	broad.mit.edu	37	chr7	134635184	134635184	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agagcagaagctgctgagaaAcgccagaagatgccagaaga	17	3	13	8	1	0	7	0	1	0	7	0	8	0	7	2	0	5	3	2	0	4	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:134635184A>G	uc003vrz.2	+	9	2313	c.1854A>G	c.(1852-1854)AAA>AAG	p.K618K	CALD1_uc003vry.2_Silent_p.K363K|CALD1_uc003vsa.2_Silent_p.K389K|CALD1_uc003vsb.2_Silent_p.K363K|CALD1_uc010lmm.2_Silent_p.K389K|CALD1_uc011kpt.1_Silent_p.K137K|CALD1_uc003vsc.2_Silent_p.K383K|CALD1_uc003vsd.2_Silent_p.K357K|CALD1_uc011kpu.1_Silent_p.K368K|CALD1_uc011kpv.1_Silent_p.K227K|CALD1_uc003vse.2_Silent_p.K482K	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	618	Tropomyosin-binding (Potential).				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						CTGCTGAGAAACGCCAGAAGA	0.433													36	68					0	0	0	0	G	134635184	G	G	134635184	2	3	60	1	0	0	0	0	0	0	0	1	2593	40	2	5		5	CALD1	7	134635184	Silent	SNP	A	TCGA-CN-5363-01A-01D-1434-08	12935326	134635184	24503479	125	12221											
CNTNAP2	26047	broad.mit.edu	37	chr7	146471453	146471453	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tagctattctcccggctatgCcaagataaacaagagaggag	14	8	10	9	1	1	2	0	0	1	2	2	4	1	3	2	2	3	2	2	2	7	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:146471453C>A	uc003weu.1	+	2	704	c.188C>A	c.(187-189)GCC>GAC	p.A63D		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	63	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCCGGCTATGCCAAGATAAAC	0.368										HNSCC(39;0.1)			23	43					1.64293e-13	1.94295e-13	1	0	A	146471453	A	A	146471453	3	1	60	1	0	0	0	0	1	0	0	0	3662	739	26	4	194	4	CNTNAP2	7	146471453	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	11836269	146471453	12667210	126	12222											
MLL3	58508	broad.mit.edu	37	chr7	151880230	151880230	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtaaagcagctctgttatcTctggctttttgctttgacaa	8	16	8	9	1	2	1	0	1	2	0	3	1	2	1	0	1	3	6	0	1	4	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr7:151880230T>A	uc003wla.2	-	35	5313	c.5094A>T	c.(5092-5094)AGA>AGT	p.R1698S	MLL3_uc003wkz.2_Missense_Mutation_p.R759S	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1698					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTCTGTTATCTCTGGCTTTTT	0.323			N		medulloblastoma								145	328					0	0	0	0	A	151880230	A	A	151880230	3	1	60	1	0	0	0	0	1	0	0	0	9675	1548	54	5	9741	5	MLL3	7	151880230	Missense_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	5408777	151880230	7258433	127	12223											
DLC1	10395	broad.mit.edu	37	chr8	12955928	12955930	+	In_Frame_Del	DEL	AGA	-	-																															cagctaaaaccatgcttgttAgaaggtgtgtatttctccag																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:12955928_12955930delAGA	uc003wwm.2	-	10	3589_3591	c.3145_3147delTCT	c.(3145-3147)TCTdel	p.S1049del	DLC1_uc003wwk.1_In_Frame_Del_p.S612del|DLC1_uc003wwl.1_In_Frame_Del_p.S646del|DLC1_uc011kxx.1_In_Frame_Del_p.S538del	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1049					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CATGCTTGTTAGAAGGTGTGTAT	0.424													---	---	---								-	12955930	-	-	12955928	7	5	60	1	0	1	0	1	0	0	0	0	4572	407	15	0	1475	0	DLC1	8	12955928	In_Frame_Del	DEL	AGA	TCGA-CN-5363-01A-01D-1434-08		12955928	133408094	128	12224											
INTS10	55174	broad.mit.edu	37	chr8	19701638	19701638	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcattggggcatgtgattGtgttgcttcagcaagagtgg	7	13	16	5	0	1	2	1	1	0	1	1	2	1	2	0	4	2	5	0	4	1	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:19701638G>C	uc003wzj.2	+	15	1902	c.1771G>C	c.(1771-1773)GTG>CTG	p.V591L		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	591					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		GCATGTGATTGTGTTGCTTCA	0.418													28	70					0	0	0	0	C	19701638	C	C	19701638	3	2	60	1	0	0	0	0	1	0	0	0	7815	1377	48	4	1829	4	INTS10	8	19701638	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	6745710	19701638	126662384	129	12225											
ST18	9705	broad.mit.edu	37	chr8	53071483	53071483	+	Frame_Shift_Del	DEL	T	-	-																															catgcagactctgtggcttgTtggagaggatgtctgtggct																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:53071483delT	uc003xqz.2	-	10	1937	c.1781delA	c.(1780-1782)AACfs	p.N594fs	ST18_uc011ldq.1_Frame_Shift_Del_p.N241fs|ST18_uc011ldr.1_Frame_Shift_Del_p.N559fs|ST18_uc011lds.1_Frame_Shift_Del_p.N499fs|ST18_uc003xra.2_Frame_Shift_Del_p.N594fs|ST18_uc003xrb.2_Frame_Shift_Del_p.N594fs	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	594						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CTGTGGCTTGTTGGAGAGGAT	0.542													---	---	---								-	53071483	-	-	53071483	7	5	60	1	0	1	0	1	0	0	0	0	15278	1725	60	0	1410	0	ST18	8	53071483	Frame_Shift_Del	DEL	T	TCGA-CN-5363-01A-01D-1434-08	33369845	53071483	93292539	130	12226											
MTFR1	9650	broad.mit.edu	37	chr8	66582207	66582207	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgcttggctggattaagcGcctaattaggatggtttttc	9	15	11	6	1	0	0	0	0	0	0	1	2	0	2	1	4	2	3	1	4	4	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:66582207G>T	uc003xvm.2	+	2	232	c.20G>T	c.(19-21)CGC>CTC	p.R7L	MTFR1_uc011lep.1_Missense_Mutation_p.R7L|MTFR1_uc003xvn.2_Missense_Mutation_p.R7L|MTFR1_uc003xvo.1_5'UTR	NM_014637	NP_055452	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1 isoform 1	7						mitochondrion|plasma membrane				pancreas(1)	1			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			TGGATTAAGCGCCTAATTAGG	0.368													23	205					8.24728e-16	1.00146e-15	1	0	T	66582207	T	T	66582207	3	4	60	1	0	0	0	0	1	0	0	0	9978	1087	38	3	22	3	MTFR1	8	66582207	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	13510724	66582207	79781815	131	12227											
JPH1	56704	broad.mit.edu	37	chr8	75233214	75233214	+	Frame_Shift_Del	DEL	G	-	-																															caggtaccctcgtagcgagcGggggtgcacaggctctgccg																								rs79761162	byFrequency	TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:75233214delG	uc003yae.2	-	1	349	c.309delC	c.(307-309)CCCfs	p.P103fs	JPH1_uc003yaf.2_Frame_Shift_Del_p.P103fs|JPH1_uc003yag.1_Intron	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	103	Gly-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CGTAGCGAGCGGGGGTGCACA	0.677													---	---	---								-	75233214	-	-	75233214	7	5	60	1	0	1	0	1	0	0	0	0	7999	1103	39	0	1696	0	JPH1	8	75233214	Frame_Shift_Del	DEL	G	TCGA-CN-5363-01A-01D-1434-08	8651007	75233214	71130808	132	12228											
CSMD3	114788	broad.mit.edu	37	chr8	113237020	113237020	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttataccattgtgcaaaccgTgttcaagttgggatcaaatc	12	13	8	8	1	2	0	2	0	0	0	3	1	2	1	2	1	3	3	2	1	5	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:113237020T>C	uc003ynu.2	-	71	11263	c.11104A>G	c.(11104-11106)ACG>GCG	p.T3702A	CSMD3_uc003yns.2_Missense_Mutation_p.T2904A|CSMD3_uc003ynt.2_Missense_Mutation_p.T3662A|CSMD3_uc011lhx.1_Missense_Mutation_p.T3533A	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3702	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTGCAAACCGTGTTCAAGTTG	0.423										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			134	262					0	0	0	0	C	113237020	C	C	113237020	3	2	60	1	0	0	0	0	1	0	0	0	3963	1696	59	5	23	5	CSMD3	8	113237020	Missense_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	38003806	113237020	33127002	133	12229											
CSMD3	114788	broad.mit.edu	37	chr8	113256623	113256623	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attctatagagaaaacttacCttcacaaatgggaacttttc	15	13	5	8	0	2	1	1	0	1	1	3	3	2	2	1	1	3	0	1	1	7	7			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:113256623C>T	uc003ynu.2	-	65	10561	c.10402G>A	c.(10402-10404)GCT>ACT	p.A3468T	CSMD3_uc003yns.2_Missense_Mutation_p.A2670T|CSMD3_uc003ynt.2_Missense_Mutation_p.A3428T|CSMD3_uc011lhx.1_Missense_Mutation_p.A3299T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3468	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GAAAACTTACCTTCACAAATG	0.328										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			25	161					0	0	0	0	T	113256623	T	T	113256623	3	4	60	1	0	0	0	0	1	0	0	0	3963	695	24	4	749	4	CSMD3	8	113256623	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	19603	113256623	33107399	134	12230											
CSMD3	114788	broad.mit.edu	37	chr8	113395847	113395847	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtctcccccatcataaaagtCcagagaatcccaattatgtt	13	11	5	12	0	2	1	1	0	1	1	5	2	4	1	4	0	0	1	4	0	5	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:113395847C>A	uc003ynu.2	-	37	6139	c.5980G>T	c.(5980-5982)GAC>TAC	p.D1994Y	CSMD3_uc003yns.2_Missense_Mutation_p.D1196Y|CSMD3_uc003ynt.2_Missense_Mutation_p.D1954Y|CSMD3_uc011lhx.1_Missense_Mutation_p.D1890Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1994	Extracellular (Potential).|CUB 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCATAAAAGTCCAGAGAATCC	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			45	109					1.66251e-12	1.93248e-12	1	0	A	113395847	A	A	113395847	3	1	60	1	0	0	0	0	1	0	0	0	3963	855	30	2	5283	2	CSMD3	8	113395847	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	139224	113395847	32968175	135	12231											
TMEM71	137835	broad.mit.edu	37	chr8	133723206	133723206	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcatcgaaggcattcctaaAtggttgtcaaattttgacaa	13	14	7	7	1	2	1	2	1	0	0	4	2	3	1	1	2	0	2	1	2	5	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:133723206A>G	uc003ytp.2	-	9	1063	c.834T>C	c.(832-834)CAT>CAC	p.H278H	TMEM71_uc003ytm.1_3'UTR|TMEM71_uc003ytn.2_3'UTR|TMEM71_uc003yto.2_3'UTR	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	Error:Variant_position_missing_in_Q6P5X7_after_alignment						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GCATTCCTAAATGGTTGTCAA	0.383													56	165					0	0	0	0	G	133723206	G	G	133723206	2	3	60	1	0	0	0	0	0	0	0	1	16266	116	4	5		5	TMEM71	8	133723206	Silent	SNP	A	TCGA-CN-5363-01A-01D-1434-08	20327359	133723206	12640816	136	12232											
FAM135B	51059	broad.mit.edu	37	chr8	139144990	139144990	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggattaaagtgcagtccttgGcttcaaccagagggcccagg	10	8	13	10	0	1	1	1	0	0	1	2	2	2	2	3	4	2	2	3	4	3	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:139144990G>A	uc003yuy.2	-	20	4238	c.4067C>T	c.(4066-4068)GCC>GTC	p.A1356V	FAM135B_uc003yux.2_Missense_Mutation_p.A1257V|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1356										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCAGTCCTTGGCTTCAACCAG	0.537										HNSCC(54;0.14)			96	513					0	0	0	0	A	139144990	A	A	139144990	3	1	60	1	0	0	0	0	1	0	0	0	5477	1203	42	4	157	4	FAM135B	8	139144990	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	5421784	139144990	7219032	137	12233											
FAM135B	51059	broad.mit.edu	37	chr8	139153488	139153488	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acagggttcccaggtgaggcCcagagagtgacaggaacgtg	11	5	16	9	1	0	3	0	2	0	1	1	5	1	4	2	4	1	1	2	4	1	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:139153488C>G	uc003yuy.2	-	17	3914	c.3743G>C	c.(3742-3744)GGG>GCG	p.G1248A	FAM135B_uc003yux.2_Missense_Mutation_p.G1149A|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1248										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAGGTGAGGCCCAGAGAGTGA	0.522										HNSCC(54;0.14)			20	108					0	0	0	0	G	139153488	G	G	139153488	3	3	60	1	0	0	0	0	1	0	0	0	5477	623	22	4	493	4	FAM135B	8	139153488	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	8498	139153488	7210534	138	12234											
FAM135B	51059	broad.mit.edu	37	chr8	139165358	139165358	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaggtcttccctaaaagataAattgctatttaccatacagt	15	13	5	8	0	1	1	0	0	1	1	2	1	2	1	2	1	3	1	2	1	8	8			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr8:139165358A>T	uc003yuy.2	-	13	1531	c.1360T>A	c.(1360-1362)TTA>ATA	p.L454I	FAM135B_uc003yux.2_Missense_Mutation_p.L355I|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.L16I|FAM135B_uc003yvb.2_Missense_Mutation_p.L16I	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	454										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTAAAAGATAAATTGCTATTT	0.373										HNSCC(54;0.14)			31	127					0	0	0	0	T	139165358	T	T	139165358	3	4	60	1	0	0	0	0	1	0	0	0	5477	11	1	5	2892	5	FAM135B	8	139165358	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	11870	139165358	7198664	139	12235											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18777172	18777172	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagtgaggaagaggtgcttgCggggaggaagggcggcccga	10	4	21	6	3	0	2	0	1	0	1	0	6	0	5	1	7	2	1	1	7	3	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr9:18777172C>T	uc003zne.3	+	19	3072	c.2945C>T	c.(2944-2946)GCG>GTG	p.A982V		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	982						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		GAGGTGCTTGCGGGGAGGAAG	0.672													10	184					0	0	0	0	T	18777172	T	T	18777172	3	4	60	1	0	0	0	0	1	0	0	0	274	768	27	1	3023	1	ADAMTSL1	9	18777172	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08		18777172	122436259	140	12236											
STOML2	30968	broad.mit.edu	37	chr9	35100719	35100719	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcagtgaagctgctgcatctCcattctgtgatcacaggggg	8	11	12	10	0	4	2	2	2	2	0	5	2	4	2	1	2	3	3	1	2	1	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr9:35100719C>G	uc003zwi.2	-	9	872	c.809G>C	c.(808-810)GGA>GCA	p.G270A	STOML2_uc003zwh.2_Missense_Mutation_p.G161A|STOML2_uc003zwj.2_Missense_Mutation_p.G161A|STOML2_uc011lou.1_Missense_Mutation_p.G225A|STOML2_uc003zwk.2_Missense_Mutation_p.G219A	NM_013442	NP_038470	Q9UJZ1	STML2_HUMAN	stomatin (EPB72)-like 2	270						cytoskeleton	receptor binding				0			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGCTGCATCTCCATTCTGTGA	0.512													12	207					0	0	0	0	G	35100719	G	G	35100719	3	3	60	1	0	0	0	0	1	0	0	0	15380	855	30	2	269	2	STOML2	9	35100719	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	16323547	35100719	106112712	141	12237											
TLN1	7094	broad.mit.edu	37	chr9	35717216	35717216	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagcctggtcataacggccAgcaggcccagcccctgtggc	7	6	13	15	1	1	0	1	0	0	0	1	0	1	0	5	4	4	2	5	4	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr9:35717216A>T	uc003zxt.2	-	19	2739	c.2385T>A	c.(2383-2385)GCT>GCA	p.A795A		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	795					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CATAACGGCCAGCAGGCCCAG	0.567													26	44					0	0	0	0	T	35717216	T	T	35717216	2	4	60	1	0	0	0	0	0	0	0	1	16013	175	7	5		5	TLN1	9	35717216	Silent	SNP	A	TCGA-CN-5363-01A-01D-1434-08	616497	35717216	105496215	142	12238											
PGM5	5239	broad.mit.edu	37	chr9	71002394	71002394	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagtggagatagtggaccCagtggatatctatcttaacc	11	13	10	7	0	2	1	0	0	2	1	2	4	2	3	2	3	1	0	2	3	5	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr9:71002394C>A	uc004agr.2	+	4	816	c.587C>A	c.(586-588)CCA>CAA	p.P196Q		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	196					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						ATAGTGGACCCAGTGGATATC	0.413													89	177					8.98033e-41	1.23366e-40	1	0	A	71002394	A	A	71002394	3	1	60	1	0	0	0	0	1	0	0	0	11856	594	21	4	601	4	PGM5	9	71002394	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	35285178	71002394	70211037	143	12239											
VPS13A	23230	broad.mit.edu	37	chr9	79959184	79959184	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaattgtattctattgcGtctagataacgaggtaagtt	13	14	10	4	2	2	1	0	0	2	1	2	3	2	2	0	2	2	3	0	2	7	9			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr9:79959184G>T	uc004akr.2	+	51	7402	c.7142G>T	c.(7141-7143)CGT>CTT	p.R2381L	VPS13A_uc004akp.3_Missense_Mutation_p.R2381L|VPS13A_uc004akq.3_Missense_Mutation_p.R2381L|VPS13A_uc004aks.2_Missense_Mutation_p.R2342L	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2381					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						ATTCTATTGCGTCTAGATAAC	0.299													72	89					9.98788e-38	1.36518e-37	1	0	T	79959184	T	T	79959184	3	4	60	1	0	0	0	0	1	0	0	0	17257	1145	40	3	7344	3	VPS13A	9	79959184	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	8956790	79959184	61254247	144	12240											
KIAA1529	57653	broad.mit.edu	37	chr9	100116995	100116995	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaatgagtacctggaccaGgtagggcccccagccaggcc	10	4	14	13	0	0	2	0	1	0	1	0	4	0	3	6	4	2	2	6	4	3	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr9:100116995G>C	uc011lut.1	+	35	4469	c.3696G>C	c.(3694-3696)CAG>CAC	p.Q1232H	KIAA1529_uc004axe.1_Missense_Mutation_p.Q1064H|KIAA1529_uc004axg.1_Missense_Mutation_p.Q1093H|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.Q249H	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				ACCTGGACCAGGTAGGGCCCC	0.567													67	89					0	0	0	0	C	100116995	C	C	100116995	3	2	60	1	0	0	0	0	1	0	0	0	8279	1014	35	4	3282	4	KIAA1529	9	100116995	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	20157811	100116995	41096436	145	12241											
KLF4	9314	broad.mit.edu	37	chr9	110250031	110250031	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggcggctgcggctgctgcGgcggaatgtacaccgggtcc	4	7	17	13	5	0	0	0	0	0	0	1	1	1	1	2	6	4	4	2	6	2	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr9:110250031G>A	uc004bdh.2	-	3	1238	c.617C>T	c.(616-618)CCG>CTG	p.P206L	KLF4_uc004bdf.1_Missense_Mutation_p.P165L|KLF4_uc004bdg.2_Missense_Mutation_p.P215L	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	215	Pro-rich.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3						CGGCTGCTGCGGCGGAATGTA	0.687													6	5					0	0	0	0	A	110250031	A	A	110250031	3	1	60	1	0	0	0	0	1	0	0	0	8387	1116	39	1	807	1	KLF4	9	110250031	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	10133036	110250031	30963400	146	12242											
ZNF483	158399	broad.mit.edu	37	chr9	114289921	114289921	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcaatcagtggctgagAccagacattcacacgaaaga	14	7	9	11	1	3	3	2	1	1	3	3	5	3	3	1	1	1	2	1	1	2	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr9:114289921A>G	uc004bff.2	+	2	470	c.246A>G	c.(244-246)AGA>AGG	p.R82R	ZNF483_uc011lwq.1_Silent_p.R82R|ZNF483_uc004bfg.2_Silent_p.R82R|ZNF483_uc010mud.1_Silent_p.R82R	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	82	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						AGTGGCTGAGACCAGACATTC	0.468													63	76					0	0	0	0	G	114289921	G	G	114289921	2	3	60	1	0	0	0	0	0	0	0	1	18003	272	10	5		5	ZNF483	9	114289921	Silent	SNP	A	TCGA-CN-5363-01A-01D-1434-08	4039890	114289921	26923510	147	12243											
URM1	81605	broad.mit.edu	37	chr9	131140339	131140339	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcggagctcctgtttgaCggtattaagaaacatcgagt	10	11	13	7	3	0	2	0	1	0	1	2	4	1	3	1	3	3	3	1	3	3	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr9:131140339C>T	uc004buv.2	+	2	122	c.60C>T	c.(58-60)GAC>GAT	p.D20D	URM1_uc011may.1_Silent_p.D20D|URM1_uc004buw.2_RNA	NM_030914	NP_112176	Q9BTM9	URM1_HUMAN	ubiquitin related modifier 1 homolog isoform a	20					tRNA thio-modification|tRNA wobble uridine modification		protein binding				0						TCCTGTTTGACGGTATTAAGA	0.507													17	148					0	0	0	0	T	131140339	T	T	131140339	2	4	60	1	0	0	0	0	0	0	0	1	17095	535	19	1		1	URM1	9	131140339	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	16850418	131140339	10073092	148	12244											
NOTCH1	4851	broad.mit.edu	37	chr9	139395007	139395008	+	Frame_Shift_Ins	INS	-	A	A																															ggcagccactgcctacctggINSaagacaccttgtgcgtcggc																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr9:139395007_139395008insA	uc004chz.2	-	31	5930_5931	c.5930_5931insT	c.(5929-5931)TTCfs	p.F1977fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1977	ANK 2.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TGCCTACCTGGAAGACACCTTG	0.683			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								A	139395008	A	A	139395007	7	5	60	1	0	1	1	0	0	0	0	0	10601	1165	41	0	1752	0	NOTCH1	9	139395007	Frame_Shift_Ins	INS	-	TCGA-CN-5363-01A-01D-1434-08	8254668	139395007	1818424	149	12245											
PLCE1	51196	broad.mit.edu	37	chr10	95791310	95791310	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attagtcctttaggaaatcaGtcagtgatcatagagacagg	14	11	10	6	0	3	2	3	1	0	1	4	4	4	3	1	2	0	0	1	2	4	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr10:95791310G>A	uc001kjk.2	+	2	1141	c.507G>A	c.(505-507)CAG>CAA	p.Q169Q	PLCE1_uc010qnx.1_Silent_p.Q169Q	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	169					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TAGGAAATCAGTCAGTGATCA	0.428													62	80					0	0	0	0	A	95791310	A	A	95791310	2	1	60	1	0	0	0	0	0	0	0	1	12089	1020	36	4		4	PLCE1	10	95791310	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08		95791310	39743437	150	12246											
SORCS3	22986	broad.mit.edu	37	chr10	106924096	106924096	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctctcatatactgatattGgtgtgttcatctcctccgat	8	16	7	10	1	3	1	2	1	2	0	6	2	4	1	2	1	2	2	2	1	3	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr10:106924096G>A	uc001kyi.1	+	12	1995	c.1768G>A	c.(1768-1770)GGT>AGT	p.G590S		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	590	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TACTGATATTGGTGTGTTCAT	0.448													32	45					0	0	0	0	A	106924096	A	A	106924096	3	1	60	1	0	0	0	0	1	0	0	0	14996	1348	47	4	1814	4	SORCS3	10	106924096	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	11132786	106924096	28610651	151	12247											
FAM160B1	57700	broad.mit.edu	37	chr10	116602933	116602933	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggcctcggttgtttgtcCaaatcaggattacaatttag	11	13	10	7	1	1	1	1	0	0	1	3	2	2	2	2	3	1	2	2	3	4	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr10:116602933C>T	uc001lcb.2	+	6	1099	c.764C>T	c.(763-765)CCA>CTA	p.P255L	FAM160B1_uc001lcc.2_Missense_Mutation_p.P255L	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	255										lung(1)	1						GTTGTTTGTCCAAATCAGGAT	0.413													64	111					0	0	0	0	T	116602933	T	T	116602933	3	4	60	1	0	0	0	0	1	0	0	0	5498	594	21	4	786	4	FAM160B1	10	116602933	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	9678837	116602933	18931814	152	12248											
PNLIPRP1	5407	broad.mit.edu	37	chr10	118351941	118351941	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcacagattctcctcctctCtgatccatcaacaattgagg	10	12	6	13	0	4	3	2	2	2	1	8	3	6	3	3	1	1	0	3	1	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr10:118351941C>T	uc001lco.1	+	4	236	c.218C>T	c.(217-219)TCT>TTT	p.S73F	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.S73F|PNLIPRP1_uc001lcn.2_Missense_Mutation_p.S73F|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	73					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		CTCCTCCTCTCTGATCCATCA	0.398													76	107					0	0	0	0	T	118351941	T	T	118351941	3	4	60	1	0	0	0	0	1	0	0	0	12205	913	32	2	228	2	PNLIPRP1	10	118351941	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	1749008	118351941	17182806	153	12249											
DMBT1	1755	broad.mit.edu	37	chr10	124339305	124339305	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagggctcaggacccattgtCctggatgatgtgcgctgctc	6	10	13	12	1	1	1	1	1	0	0	3	3	2	3	2	3	2	3	2	3	0	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr10:124339305C>A	uc001lgk.1	+	10	997	c.891C>A	c.(889-891)GTC>GTA	p.V297V	DMBT1_uc001lgl.1_Silent_p.V297V|DMBT1_uc001lgm.1_Silent_p.V297V|DMBT1_uc009xzz.1_Silent_p.V297V|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Silent_p.V149V	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	297	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GACCCATTGTCCTGGATGATG	0.597													121	153					2.98534e-63	4.20731e-63	1	0	A	124339305	A	A	124339305	2	1	60	1	0	0	0	0	0	0	0	1	4599	842	30	2		2	DMBT1	10	124339305	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	5987364	124339305	11195442	154	12250											
DMBT1	1755	broad.mit.edu	37	chr10	124351999	124351999	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggctcaggacccattgtTctggatgatgtgcgctgctc	6	11	13	11	1	2	1	1	1	1	0	3	3	2	3	1	3	2	4	1	3	0	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr10:124351999T>A	uc001lgk.1	+	20	2494	c.2388T>A	c.(2386-2388)GTT>GTA	p.V796V	DMBT1_uc001lgl.1_Silent_p.V786V|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Silent_p.V796V|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Silent_p.V409V	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	796	SRCR 6.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GACCCATTGTTCTGGATGATG	0.602													7	283					0	0	0	0	A	124351999	A	A	124351999	2	1	60	1	0	0	0	0	0	0	0	1	4599	1770	62	5		5	DMBT1	10	124351999	Silent	SNP	T	TCGA-CN-5363-01A-01D-1434-08	12694	124351999	11182748	155	12251											
OR52K2	119774	broad.mit.edu	37	chr11	4471232	4471232	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgttatcctgtcttatatCtttattcttcaggcagttct	6	21	5	9	0	5	0	1	0	4	0	6	0	6	0	1	1	0	3	1	1	4	9			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:4471232C>G	uc001lyz.1	+	1	663	c.663C>G	c.(661-663)ATC>ATG	p.I221M		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTCTTATATCTTTATTCTTC	0.483													114	189					0	0	0	0	G	4471232	G	G	4471232	3	3	60	1	0	0	0	0	1	0	0	0	11178	903	32	2	665	2	OR52K2	11	4471232	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08		4471232	130535284	156	12252											
TRIM22	10346	broad.mit.edu	37	chr11	5730848	5730848	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatccttggaactgcctagtCcccatgactgtgtgcccacc	8	10	8	15	0	0	1	0	1	0	0	2	2	2	2	6	1	3	0	6	1	3	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:5730848C>T	uc001mbr.2	+	8	1744	c.1467C>T	c.(1465-1467)GTC>GTT	p.V489V	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.2_Silent_p.V485V|TRIM22_uc010qzm.1_Silent_p.V317V|TRIM22_uc009yeu.2_Silent_p.V300V|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	489	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		ACTGCCTAGTCCCCATGACTG	0.483													51	131					0	0	0	0	T	5730848	T	T	5730848	2	4	60	1	0	0	0	0	0	0	0	1	16563	842	30	2		2	TRIM22	11	5730848	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	1259616	5730848	129275668	157	12253											
STK33	65975	broad.mit.edu	37	chr11	8435138	8435138	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcagtggacggcttattCttctcttctgttgtgttttc	3	21	8	9	1	5	0	1	0	4	0	7	1	5	1	0	2	0	3	0	2	1	8			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:8435138C>A	uc001mgi.1	-	11	2167	c.1248G>T	c.(1246-1248)AAG>AAT	p.K416N	STK33_uc001mgj.1_Missense_Mutation_p.K416N|STK33_uc001mgk.1_Missense_Mutation_p.K416N|STK33_uc010rbn.1_Missense_Mutation_p.K375N|STK33_uc001mgl.3_Missense_Mutation_p.K229N	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	416						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		ACGGCTTATTCTTCTCTTCTG	0.403													104	220					7.34945e-47	1.01475e-46	1	0	A	8435138	A	A	8435138	3	1	60	1	0	0	0	0	1	0	0	0	15366	912	32	2	304	2	STK33	11	8435138	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	2704290	8435138	126571378	158	12254											
TMEM86A	144110	broad.mit.edu	37	chr11	18723384	18723386	+	In_Frame_Del	DEL	TCT	-	-																															ggcagctggcagtggtgcacTcttctttatcatctcagacc																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:18723384_18723386delTCT	uc001moz.1	+	3	634_636	c.551_553delTCT	c.(550-555)CTCTTC>CTC	p.F186del		NM_153347	NP_699178	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	186	Helical; (Potential).					integral to membrane				ovary(1)	1						AGTGGTGCACTCTTCTTTATCAT	0.586													---	---	---								-	18723386	-	-	18723384	7	5	60	1	0	1	0	1	0	0	0	0	16274	1551	54	0	561	0	TMEM86A	11	18723384	In_Frame_Del	DEL	TCT	TCGA-CN-5363-01A-01D-1434-08	10288246	18723384	116283132	159	12255											
MRGPRX2	117194	broad.mit.edu	37	chr11	19077130	19077130	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtaaatgatggggttggCactgctgttaagagatgaca	13	10	14	4	0	0	3	0	2	0	1	0	5	0	3	0	3	1	5	0	3	4	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:19077130C>T	uc001mph.2	-	2	908	c.820G>A	c.(820-822)GCC>ACC	p.A274T		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	274	Helical; Name=7; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						ATGGGGTTGGCACTGCTGTTA	0.473													36	81					0	0	0	0	T	19077130	T	T	19077130	3	4	60	1	0	0	0	0	1	0	0	0	9820	710	25	4	176	4	MRGPRX2	11	19077130	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	353746	19077130	115929386	160	12256											
CCDC73	493860	broad.mit.edu	37	chr11	32781750	32781750	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctgaagaactttgaagagTaaaagtagatgatgactcag	16	10	10	5	0	2	7	1	4	1	3	2	7	2	7	0	0	1	2	0	0	6	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:32781750T>A	uc001mtv.2	-	2	84	c.40A>T	c.(40-42)ACT>TCT	p.T14S	CCDC73_uc001mtw.1_Missense_Mutation_p.T14S|CCDC73_uc009yjt.2_Missense_Mutation_p.T14S	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	14										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					CTTTGAAGAGTAAAAGTAGAT	0.299													55	124					0	0	0	0	A	32781750	A	A	32781750	3	1	60	1	0	0	0	0	1	0	0	0	2859	1638	57	5	3267	5	CCDC73	11	32781750	Missense_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	13704620	32781750	102224766	161	12257											
OR4C12	283093	broad.mit.edu	37	chr11	50003946	50003946	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaagtgttatcatgtaaagaAccaaaaatactacaaacgtg	20	9	6	6	1	1	1	1	0	0	1	1	1	1	1	1	0	4	2	1	0	10	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:50003946A>C	uc010ria.1	-	1	92	c.92T>G	c.(91-93)GTT>GGT	p.V31G		NM_001005270	NP_001005270	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CATGTAAAGAACCAAAAATAC	0.413													38	84					0	0	0	0	C	50003946	C	C	50003946	3	2	60	1	0	0	0	0	1	0	0	0	11100	43	2	5	841	5	OR4C12	11	50003946	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	17222196	50003946	85002570	162	12258											
OR5L2	26338	broad.mit.edu	37	chr11	55595068	55595068	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcctatgaccgctttgtggCcatctgtaaccccctgctgt	5	12	10	14	1	1	1	0	1	1	0	1	1	1	1	5	2	2	3	5	2	2	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:55595068C>T	uc001nhy.1	+	1	374	c.374C>T	c.(373-375)GCC>GTC	p.A125V		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CGCTTTGTGGCCATCTGTAAC	0.527										HNSCC(27;0.073)			81	248					0	0	0	0	T	55595068	T	T	55595068	3	4	60	1	0	0	0	0	1	0	0	0	11225	739	26	4	376	4	OR5L2	11	55595068	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	5591122	55595068	79411448	163	12259											
OR5J2	282775	broad.mit.edu	37	chr11	55944902	55944902	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccagtattttgtggaacAagagaaagtggtttctatgt	11	14	10	6	0	1	1	0	0	1	1	2	3	2	2	1	2	1	2	1	2	5	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:55944902A>C	uc010rjb.1	+	1	809	c.809A>C	c.(808-810)CAA>CCA	p.Q270P		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					TTTGTGGAACAAGAGAAAGTG	0.438													28	138					0	0	0	0	C	55944902	C	C	55944902	3	2	60	1	0	0	0	0	1	0	0	0	11219	130	5	5	811	5	OR5J2	11	55944902	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	349834	55944902	79061614	164	12260											
SPTBN2	6712	broad.mit.edu	37	chr11	66460712	66460712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcgcccatccaggcctccGcctcggcggcatcgcggtag	4	6	13	18	6	0	0	0	0	0	0	5	0	2	0	5	4	0	3	5	4	1	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:66460712G>A	uc001ojd.2	-	23	4871	c.4799C>T	c.(4798-4800)GCG>GTG	p.A1600V		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1600	Spectrin 13.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCAGGCCTCCGCCTCGGCGGC	0.622													32	111					0	0	0	0	A	66460712	A	A	66460712	3	1	60	1	0	0	0	0	1	0	0	0	15186	1087	38	1	2433	1	SPTBN2	11	66460712	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	10515810	66460712	68545804	165	12261											
TMEM135	65084	broad.mit.edu	37	chr11	86802426	86802426	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagggctgctcacaatttatAtggccaacttggtaagtatt	11	13	10	7	0	1	0	1	0	0	0	1	1	1	0	1	3	2	4	1	3	6	7			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr11:86802426A>T	uc001pch.2	+	4	408	c.385A>T	c.(385-387)ATG>TTG	p.M129L	TMEM135_uc010rtt.1_Intron|TMEM135_uc001pci.2_Missense_Mutation_p.M129L|TMEM135_uc001pcg.1_Missense_Mutation_p.M129L	NM_022918	NP_075069	Q86UB9	TM135_HUMAN	transmembrane protein 135	129						integral to membrane					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CACAATTTATATGGCCAACTT	0.279													34	55					0	0	0	0	T	86802426	T	T	86802426	3	4	60	1	0	0	0	0	1	0	0	0	16117	449	16	5	399	5	TMEM135	11	86802426	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	20341714	86802426	48204090	166	12262											
PZP	5858	broad.mit.edu	37	chr12	9310409	9310409	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcaatagtaacataggcgGagagggtcgcttcatcttct	10	10	13	8	2	3	1	1	0	2	1	4	2	3	1	0	4	1	3	0	4	4	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:9310409G>T	uc001qvl.2	-	27	3352	c.3323C>A	c.(3322-3324)TCC>TAC	p.S1108Y	PZP_uc009zgl.2_Missense_Mutation_p.S894Y	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AACATAGGCGGAGAGGGTCGC	0.428													16	57					2.48551e-13	2.91404e-13	1	0	T	9310409	T	T	9310409	3	4	60	1	0	0	0	0	1	0	0	0	12934	1174	41	2	1165	2	PZP	12	9310409	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08		9310409	124541486	167	12263											
C12orf69	440087	broad.mit.edu	37	chr12	14959602	14959602	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctctgggtaaaggaagtCactttgggccatatttccaa	10	13	10	8	0	2	0	1	0	1	0	4	1	3	1	2	3	0	2	2	3	5	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:14959602C>A	uc001rck.1	-	2	86	c.13G>T	c.(13-15)GAC>TAC	p.D5Y	C12orf60_uc001rcj.3_Intron	NM_001013698	NP_001013720	A2RU48	CL069_HUMAN	hypothetical protein LOC440087	5						integral to membrane					0						TAAAGGAAGTCACTTTGGGCC	0.388													34	170					4.65686e-17	5.78387e-17	1	0	A	14959602	A	A	14959602	3	1	60	1	0	0	0	0	1	0	0	0	1717	826	29	2	668	2	C12orf69	12	14959602	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	5649193	14959602	118892293	168	12264											
STK38L	23012	broad.mit.edu	37	chr12	27467947	27467947	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttactggatttttttttaGggtcatgtaaaattatctga	10	21	7	3	0	2	1	1	1	1	0	2	2	2	2	0	2	1	1	0	2	5	9			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:27467947G>A	uc001rhr.2	+	8	872	c.673_splice	c.e8-1	p.G225_splice	STK38L_uc001rhs.2_Splice_Site|STK38L_uc010sjm.1_Splice_Site_p.G132_splice|STK38L_uc010sjn.1_Splice_Site|STK38L_uc010sjo.1_5'Flank	NM_015000	NP_055815	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like						intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|kidney(1)	5	Colorectal(261;0.0847)					TTTTTTTTTAGGGTCATGTAA	0.289													4	109					0	0	0	0	A	27467947	A	A	27467947	5	1	60	1	0	0	0	0	0	0	1	0	15370	1014	35	4	698	4	STK38L	12	27467947	Splice_Site	SNP	G	TCGA-CN-5363-01A-01D-1434-08	12508345	27467947	106383948	169	12265											
SLC2A13	114134	broad.mit.edu	37	chr12	40258621	40258621	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctattggcttaaaagtgatgCgtggggaaacttgggctgat	10	12	14	5	1	0	2	0	2	0	0	0	3	0	3	0	4	2	2	0	4	4	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:40258621C>G	uc010skm.1	-	6	1313	c.1262G>C	c.(1261-1263)CGC>CCC	p.R421P	C12orf40_uc009zjv.1_Intron|SLC2A13_uc001rme.1_Missense_Mutation_p.R68P	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	421	Extracellular (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				AAAAGTGATGCGTGGGGAAAC	0.408										HNSCC(50;0.14)			28	148					0	0	0	0	G	40258621	G	G	40258621	3	3	60	1	0	0	0	0	1	0	0	0	14606	768	27	3	704	3	SLC2A13	12	40258621	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	12790674	40258621	93593274	170	12266											
SPATS2	65244	broad.mit.edu	37	chr12	49883256	49883256	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcttttccagataaatgcGgtacgtgcaatagttcctaa	12	13	7	9	2	1	1	0	0	1	1	3	1	3	1	2	1	3	3	2	1	6	7			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:49883256G>C	uc001rud.2	+	5	1103	c.114G>C	c.(112-114)GCG>GCC	p.A38A	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Silent_p.A38A|SPATS2_uc001ruf.2_Silent_p.A38A|SPATS2_uc001rug.2_Silent_p.A38A	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	38						cytoplasm				breast(1)	1						AGATAAATGCGGTACGTGCAA	0.373													18	43					0	0	0	0	C	49883256	C	C	49883256	2	2	60	1	0	0	0	0	0	0	0	1	15085	1103	39	3		3	SPATS2	12	49883256	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	9624635	49883256	83968639	171	12267											
ZC3H10	84872	broad.mit.edu	37	chr12	56510337	56510338	+	5'Flank	INS	-	G	G																															cattgggtagccccgcccttINSggggggggcaaagggcgtga																								rs146192315	by1000genomes	TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:56510337_56510338insG	uc001sjp.1	+						RPL41_uc001sjn.2_5'Flank|RPL41_uc001sjo.2_5'Flank	NM_032786	NP_116175	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10								nucleic acid binding|zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.12)			GCCCCGCCCTTGGGGGGGGCAA	0.545													---	---	---								G	56510338	G	G	56510337	6	5	60	0	1	1	1	0	0	0	0	0	17626	1827	63	0		0	ZC3H10	12	56510337	5'Flank	INS	-	TCGA-CN-5363-01A-01D-1434-08	6627081	56510337	77341558	172	12268											
CNPY2	10330	broad.mit.edu	37	chr12	56708706	56708706	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aatggtcttcttggggtccaCctgggcaatttcccattcta	7	14	9	11	0	3	0	0	0	3	0	5	0	5	0	3	4	0	1	3	4	3	5	rs79111613		TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:56708706C>G	uc001sku.1	-	3	674	c.133G>C	c.(133-135)GTG>CTG	p.V45L	CNPY2_uc001skv.2_Missense_Mutation_p.V45L	NM_014255	NP_055070	Q9Y2B0	CNPY2_HUMAN	canopy 2 homolog precursor	45	Saposin B-type.					endoplasmic reticulum|integral to plasma membrane	protein binding				0						TTGGGGTCCACCTGGGCAATT	0.537													6	172					0	0	0	0	G	56708706	G	G	56708706	3	3	60	1	0	0	0	0	1	0	0	0	3643	507	18	4	431	4	CNPY2	12	56708706	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	198369	56708706	77143189	173	12269											
TAC3	6866	broad.mit.edu	37	chr12	57409476	57409476	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggagacttaccttgctgcGgcccccgccaggaaccacct	7	6	12	16	2	0	1	0	0	0	1	0	3	0	2	6	4	4	1	6	4	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:57409476G>T	uc001smp.2	-	2	266	c.106C>A	c.(106-108)CGC>AGC	p.R36S	TAC3_uc001smr.2_RNA|TAC3_uc001smq.2_RNA|TAC3_uc001smt.2_RNA|TAC3_uc001sms.2_RNA|TAC3_uc010sqy.1_RNA|TAC3_uc001smu.2_RNA|TAC3_uc001smv.2_RNA|TAC3_uc001smo.2_Missense_Mutation_p.R36S	NM_013251	NP_037383	Q9UHF0	TKNK_HUMAN	tachykinin 3 precursor	36					female pregnancy|neuropeptide signaling pathway|tachykinin receptor signaling pathway	extracellular space|soluble fraction	receptor binding			ovary(1)|skin(1)	2						ACCTTGCTGCGGCCCCCGCCA	0.602													17	153					1.56452e-12	1.8264e-12	1	0	T	57409476	T	T	57409476	3	4	60	1	0	0	0	0	1	0	0	0	15565	1116	39	3	279	3	TAC3	12	57409476	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	700770	57409476	76442419	174	12270											
OAS2	4939	broad.mit.edu	37	chr12	113444353	113444353	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgaaacttcattcgctcccGgcccaccaaactaaaggatt	12	8	7	14	3	1	0	1	0	0	0	3	2	2	1	3	2	2	1	3	2	4	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:113444353G>T	uc001tuj.2	+	8	1744	c.1604G>T	c.(1603-1605)CGG>CTG	p.R535L	OAS2_uc001tui.1_Missense_Mutation_p.R535L	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	535	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						ATTCGCTCCCGGCCCACCAAA	0.463													97	198					5.89325e-56	8.17839e-56	1	0	T	113444353	T	T	113444353	3	4	60	1	0	0	0	0	1	0	0	0	10854	1116	39	3	1705	3	OAS2	12	113444353	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	56034877	113444353	20407542	175	12271											
FBXW8	26259	broad.mit.edu	37	chr12	117465849	117465849	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagacaccgggggctgatcCgcgcctatgagtttgcggtg	6	9	15	11	4	0	3	0	2	0	1	1	3	1	3	3	3	1	2	3	3	2	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:117465849C>T	uc001twg.1	+	11	1751	c.1669C>T	c.(1669-1671)CGC>TGC	p.R557C	FBXW8_uc001twf.1_Missense_Mutation_p.R491C|FBXW8_uc009zwp.1_RNA	NM_153348	NP_699179	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8 isoform	557							protein binding			ovary(2)|pancreas(1)	3	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		GGGGCTGATCCGCGCCTATGA	0.622													3	58					0	0	0	0	T	117465849	T	T	117465849	3	4	60	1	0	0	0	0	1	0	0	0	5802	652	23	1	1711	1	FBXW8	12	117465849	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	4021496	117465849	16386046	176	12272											
CIT	11113	broad.mit.edu	37	chr12	120195319	120195319	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtaaaatttctgttgcctGagttcagaaatcatctcttc	11	15	7	8	0	4	2	2	1	2	1	6	2	4	2	1	1	1	3	1	1	3	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:120195319G>C	uc001txi.1	-	21	2489	c.2436C>G	c.(2434-2436)CTC>CTG	p.L812L	CIT_uc001txh.1_Silent_p.L346L|CIT_uc001txj.1_Silent_p.L854L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	812	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TCTGTTGCCTGAGTTCAGAAA	0.527													36	192					0	0	0	0	C	120195319	C	C	120195319	2	2	60	1	0	0	0	0	0	0	0	1	3453	1277	45	2		2	CIT	12	120195319	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	2729470	120195319	13656576	177	12273											
TMEM132D	121256	broad.mit.edu	37	chr12	129694087	129694087	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatcacgtcttcatcagacGatctacactccacagactcc	12	10	4	15	2	5	2	3	0	2	2	7	3	7	2	2	0	1	0	2	0	2	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:129694087G>T	uc009zyl.1	-	5	1749	c.1421C>A	c.(1420-1422)TCG>TAG	p.S474*		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	474	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTCATCAGACGATCTACACTC	0.562													7	58					0.00198382	0.00211607	1	0	T	129694087	T	T	129694087	4	4	60	1	0	0	0	0	0	1	0	0	16113	1059	37	3	1898	3	TMEM132D	12	129694087	Nonsense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	9498768	129694087	4157808	178	12274											
ANKLE2	23141	broad.mit.edu	37	chr12	133331554	133331554	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggtagaaagaagacagcCttcctccttgctccagtaaa	12	9	10	10	0	0	3	0	0	0	3	3	3	3	3	4	2	2	3	4	2	5	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr12:133331554C>G	uc001ukx.2	-	2	414	c.347G>C	c.(346-348)AGG>ACG	p.R116T	ANKLE2_uc001uky.3_Missense_Mutation_p.R54T	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	116						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		AGAAGACAGCCTTCCTCCTTG	0.473													44	79					0	0	0	0	G	133331554	G	G	133331554	3	3	60	1	0	0	0	0	1	0	0	0	633	681	24	4	2517	4	ANKLE2	12	133331554	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	3637467	133331554	520341	179	12275											
CYSLTR2	57105	broad.mit.edu	37	chr13	49281382	49281382	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctggcaatggttcacccCtttcggcttctgcatgtcac	5	14	8	14	1	3	0	2	0	1	0	5	0	4	0	3	3	1	4	3	3	1	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr13:49281382C>T	uc010acx.1	+	6	1112	c.429C>T	c.(427-429)CCC>CCT	p.P143P	CYSLTR2_uc010acy.1_Silent_p.P143P|CYSLTR2_uc010acz.1_Silent_p.P143P|CYSLTR2_uc010ada.1_Silent_p.P143P|CYSLTR2_uc010adb.1_Silent_p.P143P|CYSLTR2_uc010adc.1_Silent_p.P143P|CYSLTR2_uc010add.1_Silent_p.P143P|CYSLTR2_uc010acw.1_Silent_p.P143P|CYSLTR2_uc001vck.2_Silent_p.P143P	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	143	Helical; Name=3; (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TGGTTCACCCCTTTCGGCTTC	0.478													60	160					0	0	0	0	T	49281382	T	T	49281382	2	4	60	1	0	0	0	0	0	0	0	1	4219	668	24	4		4	CYSLTR2	13	49281382	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08		49281382	65888496	180	12276											
THSD1	55901	broad.mit.edu	37	chr13	52971420	52971420	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgcagaaaaatggcttctgCttgaaatgccaaagtcaaag	15	10	9	7	0	2	2	1	1	1	1	2	2	2	2	1	1	3	3	1	1	5	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr13:52971420C>T	uc001vgo.2	-	3	1513	c.968G>A	c.(967-969)AGC>AAC	p.S323N	THSD1_uc001vgp.2_Missense_Mutation_p.S323N|THSD1_uc010tgz.1_Intron|THSD1_uc010aea.2_Intron	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	323	Extracellular (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		ATGGCTTCTGCTTGAAATGCC	0.378													39	63					0	0	0	0	T	52971420	T	T	52971420	3	4	60	1	0	0	0	0	1	0	0	0	15943	797	28	4	1602	4	THSD1	13	52971420	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	3690038	52971420	62198458	181	12277											
PCDH17	27253	broad.mit.edu	37	chr13	58208417	58208417	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgctagacgtgaatgacaaCgcgccagtgatcgtgctccc	9	8	12	12	4	0	4	0	3	0	1	2	4	1	4	2	0	3	2	2	0	3	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr13:58208417C>T	uc001vhq.1	+	1	2629	c.1737C>T	c.(1735-1737)AAC>AAT	p.N579N	PCDH17_uc010aec.1_Silent_p.N579N	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	579	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGAATGACAACGCGCCAGTGA	0.642													14	51					0	0	0	0	T	58208417	T	T	58208417	2	4	60	1	0	0	0	0	0	0	0	1	11566	535	19	1		1	PCDH17	13	58208417	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	5236997	58208417	56961461	182	12278											
TOX4	9878	broad.mit.edu	37	chr14	21957451	21957451	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttcagcatatgctttattCtttcgtgatacacaggctgc	8	16	8	9	1	2	1	1	1	1	0	3	1	2	1	0	1	4	4	0	1	3	7			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:21957451C>G	uc001waz.2	+	5	802	c.699C>G	c.(697-699)TTC>TTG	p.F233L	TOX4_uc001way.2_Missense_Mutation_p.F103L|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Missense_Mutation_p.F210L|TOX4_uc010tlv.1_Missense_Mutation_p.F103L	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	233	HMG box.					chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		ATGCTTTATTCTTTCGTGATA	0.448													30	405					0	0	0	0	G	21957451	G	G	21957451	3	3	60	1	0	0	0	0	1	0	0	0	16447	912	32	2	717	2	TOX4	14	21957451	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08		21957451	85392089	183	12279											
ADCY4	196883	broad.mit.edu	37	chr14	24794669	24794670	+	Frame_Shift_Del	DEL	AG	-	-																															tatttgaaggcggggattgcAgagagtcggtactgaaagtg																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:24794669_24794670delAG	uc001wov.2	-	14	1742_1743	c.1736_1737delCT	c.(1735-1737)TCTfs	p.S579fs	ADCY4_uc001wow.2_Frame_Shift_Del_p.S579fs|ADCY4_uc010toh.1_Frame_Shift_Del_p.S265fs|ADCY4_uc001wox.2_Frame_Shift_Del_p.S579fs|ADCY4_uc001woy.2_Frame_Shift_Del_p.S579fs	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	579	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		CGGGGATTGCAGAGAGTCGGTA	0.54													---	---	---								-	24794670	-	-	24794669	7	5	60	1	0	1	0	1	0	0	0	0	296	175	7	0	1544	0	ADCY4	14	24794669	Frame_Shift_Del	DEL	AG	TCGA-CN-5363-01A-01D-1434-08	2837218	24794669	82554871	184	12280											
FOXG1	2290	broad.mit.edu	37	chr14	29237742	29237742	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaccagttactttttcccCcacgtcccgcacccgtcaat	8	10	5	18	3	1	1	1	0	0	1	3	1	3	1	5	0	1	2	5	0	2	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:29237742C>T	uc001wqe.2	+	1	1456	c.1257C>T	c.(1255-1257)CCC>CCT	p.P419P		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	419					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		ACTTTTTCCCCCACGTCCCGC	0.687													32	67					0	0	0	0	T	29237742	T	T	29237742	2	4	60	1	0	0	0	0	0	0	0	1	6041	610	22	4		4	FOXG1	14	29237742	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	4443073	29237742	78111798	185	12281											
SSTR1	6751	broad.mit.edu	37	chr14	38678698	38678698	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggccccggggccggcgctgCggacggcatggaggagccag	5	2	21	13	5	0	0	0	0	0	0	0	3	0	3	4	8	2	2	4	8	0	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:38678698C>A	uc001wul.1	+	3	721	c.104C>A	c.(103-105)GCG>GAG	p.A35E	SSTR1_uc010amu.1_RNA	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	35	Extracellular (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GCCGGCGCTGCGGACGGCATG	0.697													12	30					5.50884e-06	5.96974e-06	1	0	A	38678698	A	A	38678698	3	1	60	1	0	0	0	0	1	0	0	0	15263	768	27	3	106	3	SSTR1	14	38678698	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	9440956	38678698	68670842	186	12282											
SEC23A	10484	broad.mit.edu	37	chr14	39517935	39517935	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attctccaaatttctgacacTaaataaaataaaatgtgtta	18	14	3	6	0	2	1	0	1	2	0	3	1	2	1	1	0	0	1	1	0	8	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:39517935T>A	uc001wup.1	-	15	1883	c.1660_splice	c.e15-1	p.C554_splice	SEC23A_uc010tqa.1_Splice_Site_p.C416_splice|SEC23A_uc010tqb.1_Splice_Site_p.C525_splice	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		TTTCTGACACTAAATAAAATA	0.313													12	71					0	0	0	0	A	39517935	A	A	39517935	5	1	60	1	0	0	0	0	0	0	1	0	14056	1536	53	5	663	5	SEC23A	14	39517935	Splice_Site	SNP	T	TCGA-CN-5363-01A-01D-1434-08	839237	39517935	67831605	187	12283											
LRFN5	145581	broad.mit.edu	37	chr14	42356462	42356462	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ataaattgcagaagctaccaCctgaccctctctttcagcga	12	10	6	13	1	2	2	1	1	1	1	3	3	2	2	3	0	4	2	3	0	4	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:42356462C>A	uc001wvm.2	+	3	1832	c.634C>A	c.(634-636)CCT>ACT	p.P212T	LRFN5_uc010ana.2_Missense_Mutation_p.P212T	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	212	Extracellular (Potential).|LRR 7.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GAAGCTACCACCTGACCCTCT	0.433										HNSCC(30;0.082)			41	130					5.71845e-15	6.82201e-15	1	0	A	42356462	A	A	42356462	3	1	60	1	0	0	0	0	1	0	0	0	8991	507	18	4	636	4	LRFN5	14	42356462	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	2838527	42356462	64993078	188	12284											
L2HGDH	79944	broad.mit.edu	37	chr14	50736024	50736024	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagtcctgcacatgtcacaaCatactgacatcgaatttcct	13	11	5	12	1	1	1	1	1	0	0	4	2	3	1	2	0	3	1	2	0	4	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:50736024C>G	uc001wxu.2	-	7	842	c.763G>C	c.(763-765)GTT>CTT	p.V255L	L2HGDH_uc010tqn.1_Missense_Mutation_p.V255L|L2HGDH_uc010tqo.1_Missense_Mutation_p.V255L	NM_024884	NP_079160	Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase precursor	255					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)					CATGTCACAACATACTGACAT	0.418													61	246					0	0	0	0	G	50736024	G	G	50736024	3	3	60	1	0	0	0	0	1	0	0	0	8630	478	17	4	644	4	L2HGDH	14	50736024	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	8379562	50736024	56613516	189	12285											
HEATR4	399671	broad.mit.edu	37	chr14	73985749	73985749	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcaggaattgcctgggcActccacttttctggagtttc	6	14	10	11	0	2	0	1	0	1	0	4	2	3	2	2	3	1	3	2	3	1	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:73985749A>T	uc010tub.1	-	5	1510	c.1188T>A	c.(1186-1188)AGT>AGA	p.S396R	HEATR4_uc010tua.1_Missense_Mutation_p.S349R	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TTGCCTGGGCACTCCACTTTT	0.468													38	114					0	0	0	0	T	73985749	T	T	73985749	3	4	60	1	0	0	0	0	1	0	0	0	7069	156	6	5	1948	5	HEATR4	14	73985749	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	23249725	73985749	33363791	190	12286											
TTLL5	23093	broad.mit.edu	37	chr14	76249857	76249857	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccagaaactgtctcgtccCtcttcagcaaaggcaggtga	11	8	10	12	1	3	2	1	1	2	1	5	2	4	2	2	2	3	2	2	2	2	1	rs140291071	by1000genomes	TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:76249857C>T	uc001xrx.2	+	26	3175	c.2970C>T	c.(2968-2970)CCC>CCT	p.P990P	TTLL5_uc010ask.1_Silent_p.P1004P|TTLL5_uc001xrz.2_Silent_p.P565P|TTLL5_uc001xsa.2_Silent_p.P63P|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	990					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		TGTCTCGTCCCTCTTCAGCAA	0.512													33	129					0	0	0	0	T	76249857	T	T	76249857	2	4	60	1	0	0	0	0	0	0	0	1	16798	668	24	4		4	TTLL5	14	76249857	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	2264108	76249857	31099683	191	12287											
NRXN3	9369	broad.mit.edu	37	chr14	80328091	80328091	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcacaacagggatggtcgtCggcattgtggctgctgccgc	7	8	15	11	3	0	0	0	0	0	0	2	1	0	1	1	4	4	4	1	4	1	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:80328091C>T	uc001xun.2	+	17	3461	c.2970C>T	c.(2968-2970)GTC>GTT	p.V990V	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Silent_p.V566V|NRXN3_uc010asw.2_Silent_p.V388V|NRXN3_uc001xur.3_Silent_p.V361V	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1572	Helical; (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GGATGGTCGTCGGCATTGTGG	0.607													20	51					0	0	0	0	T	80328091	T	T	80328091	2	4	60	1	0	0	0	0	0	0	0	1	10721	871	31	1		1	NRXN3	14	80328091	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	4078234	80328091	27021449	192	12288											
SERPINA10	51156	broad.mit.edu	37	chr14	94750385	94750385	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatcatgaaatgaaatggccGgtccactttgatgacaggag	13	9	12	7	1	1	4	1	4	0	0	2	6	2	5	2	3	0	0	2	3	2	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr14:94750385G>A	uc001yct.2	-	5	1718	c.1252C>T	c.(1252-1254)CGG>TGG	p.R418W	SERPINA10_uc001ycu.3_Missense_Mutation_p.R418W	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	418					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TGAAATGGCCGGTCCACTTTG	0.453													4	156					0	0	0	0	A	94750385	A	A	94750385	3	1	60	1	0	0	0	0	1	0	0	0	14152	1115	39	1	86	1	SERPINA10	14	94750385	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	14422294	94750385	12599155	193	12289											
APBA2	321	broad.mit.edu	37	chr15	29386517	29386517	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctaagatcaagaaaaaagcgGtgtgtagggccttgaggccc	13	7	13	8	1	1	3	1	1	0	2	1	3	1	3	2	3	1	1	2	3	6	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr15:29386517G>T	uc001zck.2	+	7	1458	c.1251_splice	c.e7+1	p.A417_splice	APBA2_uc010azj.2_Intron|APBA2_uc010uat.1_Intron|APBA2_uc001zcl.2_Intron|APBA2_uc001zcm.1_Intron	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,						nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GAAAAAAGCGGTGTGTAGGGC	0.517													42	114					1.86633e-21	2.45238e-21	1	0	T	29386517	T	T	29386517	5	4	60	1	0	0	0	0	0	0	1	0	757	1275	44	4	1270	4	APBA2	15	29386517	Splice_Site	SNP	G	TCGA-CN-5363-01A-01D-1434-08		29386517	73144875	194	12290											
AQP9	366	broad.mit.edu	37	chr15	58471405	58471405	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggagcccccagaggcctaGagcccattgccatcggcctc	7	6	12	16	1	0	2	0	0	0	2	2	3	0	3	6	3	3	0	6	3	1	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr15:58471405G>C	uc002aez.2	+	5	931	c.574G>C	c.(574-576)GAG>CAG	p.E192Q	ALDH1A2_uc010ugw.1_Intron|AQP9_uc010ugx.1_Missense_Mutation_p.E127Q	NM_020980	NP_066190	O43315	AQP9_HUMAN	aquaporin 9	192	Helical; (Potential).				cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			ovary(1)	1				GBM - Glioblastoma multiforme(80;0.16)		CAGAGGCCTAGAGCCCATTGC	0.552													14	65					0	0	0	0	C	58471405	C	C	58471405	3	2	60	1	0	0	0	0	1	0	0	0	833	943	33	2	592	2	AQP9	15	58471405	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	29084888	58471405	44059987	195	12291											
HERC1	8925	broad.mit.edu	37	chr15	64041644	64041644	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaatagctatgccatctaagCcactcactttctttggttta	10	15	6	10	0	3	0	1	0	2	0	3	1	3	0	2	1	3	2	2	1	5	7			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr15:64041644C>A	uc002amp.2	-	10	2289	c.2141G>T	c.(2140-2142)GGC>GTC	p.G714V	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	714	RCC1 7.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GCCATCTAAGCCACTCACTTT	0.428													74	128					6.6428e-20	8.52284e-20	1	0	A	64041644	A	A	64041644	3	1	60	1	0	0	0	0	1	0	0	0	7096	739	26	4	12720	4	HERC1	15	64041644	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	5570239	64041644	38489748	196	12292											
MSLN	10232	broad.mit.edu	37	chr16	815291	815291	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcggctctgcagggcggggGacccccctacgggtaagtga	6	5	18	12	3	1	1	0	1	1	0	1	2	1	2	3	6	2	3	3	6	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr16:815291G>A	uc002cjw.1	+	8	743	c.692G>A	c.(691-693)GGA>GAA	p.G231E	MSLN_uc002cjt.1_Missense_Mutation_p.G231E|MSLN_uc002cju.1_Missense_Mutation_p.G231E|MSLN_uc010brd.1_Missense_Mutation_p.G230E|MSLN_uc002cjv.1_Missense_Mutation_p.G231E|MSLN_uc002cjx.1_Missense_Mutation_p.G231E|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	231					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				CAGGGCGGGGGACCCCCCTAC	0.692													6	6					0	0	0	0	A	815291	A	A	815291	3	1	60	1	0	0	0	0	1	0	0	0	9934	1174	41	2	718	2	MSLN	16	815291	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08		815291	89539462	197	12293											
ADCY7	113	broad.mit.edu	37	chr16	50332901	50332901	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcgctgcctacccacgcccgGaactgcgtgaagatggggct	7	7	13	14	4	0	2	0	1	0	1	1	3	0	3	3	3	4	2	3	3	3	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr16:50332901G>C	uc002egd.1	+	7	1303	c.1035G>C	c.(1033-1035)CGG>CGC	p.R345R	ADCY7_uc002egb.1_Silent_p.R345R|ADCY7_uc002egc.1_Silent_p.R345R	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	345	Cytoplasmic (Potential).|Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CCCACGCCCGGAACTGCGTGA	0.637													19	81					0	0	0	0	C	50332901	C	C	50332901	2	2	60	1	0	0	0	0	0	0	0	1	299	1161	41	2		2	ADCY7	16	50332901	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	49517610	50332901	40021852	198	12294											
GPR114	221188	broad.mit.edu	37	chr16	57597828	57597828	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagctgacccgggacgcctgCaagacccgccccagggagct	8	3	14	16	3	0	2	0	1	0	1	0	5	0	4	5	2	3	3	5	2	1	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr16:57597828C>T	uc002elx.3	+	5	451	c.366C>T	c.(364-366)TGC>TGT	p.C122C	GPR114_uc010vhr.1_Silent_p.C122C|GPR114_uc002ely.2_Silent_p.C122C	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	122	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						GGGACGCCTGCAAGACCCGCC	0.637													41	106					0	0	0	0	T	57597828	T	T	57597828	2	4	60	1	0	0	0	0	0	0	0	1	6669	718	25	4		4	GPR114	16	57597828	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	7264927	57597828	32756925	199	12295											
CDH11	1009	broad.mit.edu	37	chr16	65026867	65026867	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtccttcgaggatactgtaCactaacttggcgctatttcc	8	14	8	11	2	0	0	0	0	0	0	3	2	2	1	2	2	3	2	2	2	4	7			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr16:65026867C>A	uc002eoi.2	-	5	1028	c.594G>T	c.(592-594)GTG>GTT	p.V198V	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.V198V|CDH11_uc010vin.1_Silent_p.V72V	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	198	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GGATACTGTACACTAACTTGG	0.423			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			23	119					6.36457e-07	6.9805e-07	1	0	A	65026867	A	A	65026867	2	1	60	1	0	0	0	0	0	0	0	1	3112	465	17	4		4	CDH11	16	65026867	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	7429039	65026867	25327886	200	12296											
CHTF8	54921	broad.mit.edu	37	chr16	69155027	69155027	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtagcgagcctcgatctcccCctgtagctccatcagcaccc	7	8	8	18	2	2	0	1	0	1	0	5	2	3	0	5	0	4	4	5	0	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr16:69155027C>A	uc002ewn.1	-	3	171	c.70G>T	c.(70-72)GGG>TGG	p.G24W	CHTF8_uc002ewm.1_5'UTR|CHTF8_uc002ewo.1_Missense_Mutation_p.G5W|CHTF8_uc002ewp.1_Missense_Mutation_p.G24W	NM_001040146	NP_001035236	P0CG13	CTF8_HUMAN	chromosome transmission fidelity factor 8	24					cell cycle|DNA replication	nucleus	DNA binding				0						TCGATCTCCCCCTGTAGCTCC	0.542													36	253					6.97489e-18	8.74272e-18	1	0	A	69155027	A	A	69155027	3	1	60	1	0	0	0	0	1	0	0	0	3430	623	22	4	303	4	CHTF8	16	69155027	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	4128160	69155027	21199726	201	12297											
HYDIN	54768	broad.mit.edu	37	chr16	70863519	70863519	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggtggggggacctcagtctAcctggtgcttgcggttctcc	3	11	16	11	1	3	0	1	0	2	0	4	1	3	1	3	6	3	2	3	6	1	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr16:70863519A>T	uc002ezr.2	-	81	14237	c.14109_splice	c.e81+1	p.Q4703_splice	HYDIN_uc010cfy.2_Splice_Site	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a											ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ACCTCAGTCTACCTGGTGCTT	0.498													13	61					0	0	0	0	T	70863519	T	T	70863519	5	4	60	1	0	0	0	0	0	0	1	0	7506	405	14	5	1275	5	HYDIN	16	70863519	Splice_Site	SNP	A	TCGA-CN-5363-01A-01D-1434-08	1708492	70863519	19491234	202	12298											
ZFPM1	161882	broad.mit.edu	37	chr16	88552448	88552448	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagccccgagccctcccagcGcaggtgagtcagactgagcc	9	4	12	16	2	1	3	1	2	0	1	2	4	2	3	5	1	4	1	5	1	1	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr16:88552448G>A	uc002fkv.2	+	2	175	c.142G>A	c.(142-144)GCA>ACA	p.A48T		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	48					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CCCTCCCAGCGCAGGTGAGTC	0.642													7	33					0	0	0	0	A	88552448	A	A	88552448	3	1	60	1	0	0	0	0	1	0	0	0	17724	1087	38	1	148	1	ZFPM1	16	88552448	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	17688929	88552448	1802305	203	12299											
GEMIN4	50628	broad.mit.edu	37	chr17	650275	650279	+	Frame_Shift_Del	DEL	GCGGA	-	-																															taacttgtcccctggctgctGcggagcacggcctgcaactc																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:650275_650279delGCGGA	uc002frs.1	-	2	1123_1127	c.1004_1008delTCCGC	c.(1003-1008)CTCCGCfs	p.L335fs	GEMIN4_uc010vqa.1_3'UTR	NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	335_336					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CCTGGCTGCTGCGGAGCACGGCCTG	0.629													---	---	---								-	650279	-	-	650275	7	5	60	1	0	1	0	1	0	0	0	0	6367	1306	46	0	2172	0	GEMIN4	17	650275	Frame_Shift_Del	DEL	GCGGA	TCGA-CN-5363-01A-01D-1434-08		650275	80544935	204	12300											
TP53	7157	broad.mit.edu	37	chr17	7577092	7577092	+	Frame_Shift_Del	DEL	C	-	-																															agattctcttcctctgtgcgCcggtctctcccaggacaggc																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:7577092delC	uc002gim.2	-	8	1040	c.846delG	c.(844-846)CGGfs	p.R282fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.R282fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.R150fs|TP53_uc010cng.1_Frame_Shift_Del_p.R150fs|TP53_uc002gii.1_Frame_Shift_Del_p.R150fs|TP53_uc010cnh.1_Frame_Shift_Del_p.R282fs|TP53_uc010cni.1_Frame_Shift_Del_p.R282fs|TP53_uc002gij.2_Frame_Shift_Del_p.R282fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(365)|p.R282G(26)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.R283fs*63(2)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R283del(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTCTGTGCGCCGGTCTCTCC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7577092	-	-	7577092	7	5	60	1	0	1	0	1	0	0	0	0	16448	726	26	0	440	0	TP53	17	7577092	Frame_Shift_Del	DEL	C	TCGA-CN-5363-01A-01D-1434-08	6926817	7577092	73618118	205	12301											
PER1	5187	broad.mit.edu	37	chr17	8044393	8044393	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccagaatggagtctagctgGtgcagtttcctgctgtaggt	7	12	13	9	0	1	1	0	0	1	1	2	2	2	2	2	3	3	5	2	3	3	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:8044393G>A	uc002gkd.2	-	23	4104	c.3866C>T	c.(3865-3867)ACC>ATC	p.T1289I	PER1_uc010cns.2_Missense_Mutation_p.T163I|PER1_uc010vuq.1_RNA	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	1289	CRY binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						AGTCTAGCTGGTGCAGTTTCC	0.542			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					7	297					0	0	0	0	A	8044393	A	A	8044393	3	1	60	1	0	0	0	0	1	0	0	0	11783	1261	44	4	10	4	PER1	17	8044393	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	467301	8044393	73150817	206	12302											
AURKB	9212	broad.mit.edu	37	chr17	8111074	8111074	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgtgggctggacattggAgcggctcatgaggacaagtg	9	8	16	8	1	1	1	1	1	0	0	1	4	1	4	1	5	1	2	1	5	1	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:8111074A>G	uc002gkm.2	-	3	194	c.133T>C	c.(133-135)TCC>CCC	p.S45P	AURKB_uc010cnu.2_5'UTR|AURKB_uc002gkn.2_Missense_Mutation_p.S45P|AURKB_uc010vuu.1_Missense_Mutation_p.S4P|AURKB_uc002gko.2_RNA	NM_004217	NP_004208	Q96GD4	AURKB_HUMAN	aurora kinase B	45					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic prometaphase|protein localization to kinetochore	chromosome passenger complex|condensed nuclear chromosome, centromeric region|cytosol|spindle	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(1)|central_nervous_system(1)	4						TGGACATTGGAGCGGCTCATG	0.612													16	48					0	0	0	0	G	8111074	G	G	8111074	3	3	60	1	0	0	0	0	1	0	0	0	1225	304	11	5	929	5	AURKB	17	8111074	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	66681	8111074	73084136	207	12303											
MYO15A	51168	broad.mit.edu	37	chr17	18046140	18046140	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacacgcatacgtgagccgcCgacgctatctcaaggtatag	11	8	10	12	5	1	1	1	1	1	0	2	2	1	1	2	1	3	3	2	1	6	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:18046140C>G	uc010vxh.1	+	24	6234	c.5896C>G	c.(5896-5898)CGA>GGA	p.R1966G		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1966	IQ 3.|Neck or regulatory domain.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CGTGAGCCGCCGACGCTATCT	0.527													4	33					0	0	0	0	G	18046140	G	G	18046140	3	3	60	1	0	0	0	0	1	0	0	0	10116	644	23	3	5986	3	MYO15A	17	18046140	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	9935066	18046140	63149070	208	12304											
SMCR7	125170	broad.mit.edu	37	chr17	18166425	18166425	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgacagggccactagcccgcGggatgaggatgacaccaagg	11	4	15	11	2	0	3	0	3	0	0	0	5	0	5	3	4	1	0	3	4	2	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:18166425G>T	uc002gst.2	+	3	384	c.173G>T	c.(172-174)CGG>CTG	p.R58L	SMCR7_uc002gsu.2_Missense_Mutation_p.R58L|SMCR7_uc010vxq.1_Missense_Mutation_p.R69L	NM_139162	NP_631901	Q96C03	SMCR7_HUMAN	Smith-Magenis syndrome chromosome region,	58						integral to membrane	protein binding				0	all_neural(463;0.228)					ACTAGCCCGCGGGATGAGGAT	0.577													16	116					2.39187e-15	2.89151e-15	1	0	T	18166425	T	T	18166425	3	4	60	1	0	0	0	0	1	0	0	0	14854	1116	39	3	216	3	SMCR7	17	18166425	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	120285	18166425	63028785	209	12305											
RNF112	7732	broad.mit.edu	37	chr17	19315865	19315865	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggggccccagcccatggcGccccgggagctccctacctg	4	5	13	19	2	0	0	0	0	0	0	1	1	1	1	7	4	3	1	7	4	1	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:19315865G>T	uc010vyw.1	+	3	349	c.150G>T	c.(148-150)GCG>GCT	p.A50A	RNF112_uc010vyu.1_Silent_p.A50A|RNF112_uc010vyv.1_Silent_p.A50A|RNF112_uc010vyx.1_Silent_p.A2A	NM_007148	NP_009079	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	50							GTP binding|GTPase activity|zinc ion binding			ovary(2)	2						AGCCCATGGCGCCCCGGGAGC	0.617													9	42					4.68919e-08	5.1638e-08	1	0	T	19315865	T	T	19315865	2	4	60	1	0	0	0	0	0	0	0	1	13491	1074	38	3		3	RNF112	17	19315865	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	1149440	19315865	61879345	210	12306											
BLMH	642	broad.mit.edu	37	chr17	28601109	28601109	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgttccctgtaaaactccAagggtgttatggggccaatt	10	12	10	9	0	0	0	0	0	0	0	2	0	2	0	3	3	1	3	3	3	5	4			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:28601109A>T	uc002hez.1	-	7	989	c.752T>A	c.(751-753)TTG>TAG	p.L251*	BLMH_uc010wbn.1_Nonsense_Mutation_p.L164*	NM_000386	NP_000377	Q13867	BLMH_HUMAN	bleomycin hydrolase	251					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			ovary(1)	1						GTAAAACTCCAAGGGTGTTAT	0.428													39	126					0	0	0	0	T	28601109	T	T	28601109	4	4	60	1	0	0	0	0	0	1	0	0	1449	131	5	5	639	5	BLMH	17	28601109	Nonsense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08	9285244	28601109	52594101	211	12307											
TMEM98	26022	broad.mit.edu	37	chr17	31267870	31267870	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaatgcctgccatctgacGggaggcctggactggattga	9	8	15	9	1	1	2	0	2	1	0	1	6	1	6	3	5	2	0	3	5	1	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:31267870G>A	uc002hhq.2	+	8	998	c.540G>A	c.(538-540)ACG>ACA	p.T180T	TMEM98_uc002hhr.2_Silent_p.T180T	NM_015544	NP_056359	Q9Y2Y6	TMM98_HUMAN	transmembrane protein 98	180						endoplasmic reticulum|integral to membrane					0		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)			GCCATCTGACGGGAGGCCTGG	0.547													32	144					0	0	0	0	A	31267870	A	A	31267870	2	1	60	1	0	0	0	0	0	0	0	1	16291	1103	39	1		1	TMEM98	17	31267870	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	2666761	31267870	49927340	212	12308											
CCL16	6360	broad.mit.edu	37	chr17	34308415	34308415	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaagccgaagtaatgataagGatgaggacaaggagagacag	18	4	15	4	1	0	3	0	2	0	1	0	9	0	6	1	3	1	1	1	3	5	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:34308415G>A	uc002hkl.2	-	1	109	c.42C>T	c.(40-42)ATC>ATT	p.I14I	CCL16_uc002hkm.2_RNA	NM_004590	NP_004581	O15467	CCL16_HUMAN	small inducible cytokine A16 precursor	14					cell-cell signaling|immune response|inflammatory response	extracellular space	chemoattractant activity|chemokine activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TAATGATAAGGATGAGGACAA	0.557													8	31					0	0	0	0	A	34308415	A	A	34308415	2	1	60	1	0	0	0	0	0	0	0	1	2900	1164	41	2		2	CCL16	17	34308415	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	3040545	34308415	46886795	213	12309											
BRCA1	672	broad.mit.edu	37	chr17	41246660	41246660	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagccttttctacattcatTctgtctttagtgagtaataa	10	18	5	8	0	5	1	2	1	3	0	5	1	5	1	1	0	2	1	1	0	4	9			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:41246660T>C	uc002icq.2	-	10	1120	c.888A>G	c.(886-888)AGA>AGG	p.R296R	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Silent_p.R225R|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Silent_p.R249R|BRCA1_uc002ict.2_Silent_p.R296R|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Silent_p.R296R|BRCA1_uc002ide.1_Silent_p.R127R|BRCA1_uc010cyy.1_Silent_p.R296R|BRCA1_uc010whs.1_Silent_p.R296R|BRCA1_uc010cyz.2_Silent_p.R249R|BRCA1_uc010cza.2_Silent_p.R270R|BRCA1_uc010wht.1_5'UTR	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	296					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTACATTCATTCTGTCTTTAG	0.408			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			52	145					0	0	0	0	C	41246660	C	C	41246660	2	2	60	1	0	0	0	0	0	0	0	1	1503	1780	62	5		5	BRCA1	17	41246660	Silent	SNP	T	TCGA-CN-5363-01A-01D-1434-08	6938245	41246660	39948550	214	12310											
COL1A1	1277	broad.mit.edu	37	chr17	48278851	48278851	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gccgctaagaggagcaggagCcggaggtccacaaagctgaa	13	3	15	10	2	0	2	0	1	0	1	1	5	1	5	3	4	3	3	3	4	3	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:48278851C>A	uc002iqm.2	-	1	150	c.24G>T	c.(22-24)CGG>CGT	p.R8R		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	8					axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	GGAGCAGGAGCCGGAGGTCCA	0.592			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						9	52					0.00448238	0.00476253	1	0	A	48278851	A	A	48278851	2	1	60	1	0	0	0	0	0	0	0	1	3692	726	26	4		4	COL1A1	17	48278851	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	7032191	48278851	32916359	215	12311											
MPO	4353	broad.mit.edu	37	chr17	56348209	56348209	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcatgctgaacacaccctcGttctcccaccaaaacctgca	11	8	5	17	1	1	1	0	1	1	0	3	1	1	1	4	0	5	4	4	0	3	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:56348209G>C	uc002ivu.1	-	12	2223	c.2046C>G	c.(2044-2046)AAC>AAG	p.N682K		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	682					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	ACACACCCTCGTTCTCCCACC	0.577													7	109					0	0	0	0	C	56348209	C	C	56348209	3	2	60	1	0	0	0	0	1	0	0	0	9785	1136	40	3	195	3	MPO	17	56348209	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	8069358	56348209	24847001	216	12312											
HELZ	9931	broad.mit.edu	37	chr17	65174991	65174991	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttagaggaagaatcccaaCgtttagctgtggttactagc	11	12	10	8	1	1	2	0	0	1	2	2	3	2	3	1	2	4	3	1	2	7	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr17:65174991C>A	uc010wqk.1	-	13	1401	c.1214G>T	c.(1213-1215)CGT>CTT	p.R405L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.R405L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGAATCCCAACGTTTAGCTGT	0.348													17	141					1.33834e-09	1.51049e-09	1	0	A	65174991	A	A	65174991	3	1	60	1	0	0	0	0	1	0	0	0	7088	536	19	3	4698	3	HELZ	17	65174991	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	8826782	65174991	16020219	217	12313											
KLHL14	57565	broad.mit.edu	37	chr18	30254696	30254696	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccaacggttctgctacatctCcttcgagttctgtccaggtt	6	14	8	13	2	3	0	0	0	3	0	6	1	4	0	3	2	3	4	3	2	2	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr18:30254696C>T	uc002kxm.1	-	9	2199	c.1811G>A	c.(1810-1812)GGA>GAA	p.G604E	KLHL14_uc010dmd.1_Missense_Mutation_p.G153E	NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	604	Kelch 6.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						TGCTACATCTCCTTCGAGTTC	0.468													74	174					0	0	0	0	T	30254696	T	T	30254696	3	4	60	1	0	0	0	0	1	0	0	0	8409	855	30	2	79	2	KLHL14	18	30254696	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08		30254696	47822552	218	12314											
ZNF516	9658	broad.mit.edu	37	chr18	74154630	74154630	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctgcgaggccccgttcagCagccggttgcaggccgaggc	5	5	16	15	4	1	0	1	0	0	0	1	2	1	0	5	4	4	4	5	4	0	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr18:74154630C>A	uc010dqx.1	-	2	616	c.381G>T	c.(379-381)CTG>CTT	p.L127L	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CCCCGTTCAGCAGCCGGTTGC	0.751													5	6					5.18039e-06	5.63627e-06	1	0	A	74154630	A	A	74154630	2	1	60	1	0	0	0	0	0	0	0	1	18027	697	25	4		4	ZNF516	18	74154630	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	43899934	74154630	3922618	219	12315											
ZNF14	7561	broad.mit.edu	37	chr19	19822314	19822314	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatctgaaggctttcccAcattgtttacatcgataggg	12	12	9	8	1	1	1	0	1	1	0	3	3	2	1	1	2	1	2	1	2	5	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr19:19822314A>T	uc002nnk.1	-	4	1930	c.1776T>A	c.(1774-1776)TGT>TGA	p.C592*		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	592	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				AGGCTTTCCCACATTGTTTAC	0.383													50	74					0	0	0	0	T	19822314	T	T	19822314	4	4	60	1	0	0	0	0	0	1	0	0	17795	157	6	5	156	5	ZNF14	19	19822314	Nonsense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08		19822314	39306669	220	12316											
NUP62	23636	broad.mit.edu	37	chr19	50412642	50412642	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggtggtggaggggccaaaCacaaagccggtgggtgctgt	9	6	19	7	1	0	0	0	0	0	0	0	2	0	1	2	7	3	1	2	7	2	0			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr19:50412642C>T	uc002pqx.2	-	2	527	c.423G>A	c.(421-423)GTG>GTA	p.V141V	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Silent_p.V141V|NUP62_uc002pqz.2_Silent_p.V141V|NUP62_uc002pra.2_Silent_p.V141V|NUP62_uc002prb.2_Silent_p.V141V|NUP62_uc002prc.2_Silent_p.V141V	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	141	15 X 9 AA approximate repeats.|Thr-rich.|9.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		AGGGGCCAAACACAAAGCCGG	0.602													11	108					0	0	0	0	T	50412642	T	T	50412642	2	4	60	1	0	0	0	0	0	0	0	1	10822	465	17	4		4	NUP62	19	50412642	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08	30590328	50412642	8716341	221	12317											
LRRC4B	94030	broad.mit.edu	37	chr19	51020919	51020919	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccaggcgggcctttgcccCcgcagcccccgccgctgggg	2	4	16	19	4	0	0	0	0	0	0	0	0	0	0	7	5	2	2	7	5	0	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr19:51020919C>A	uc002pss.2	-	3	2188	c.2051G>T	c.(2050-2052)GGG>GTG	p.G684V	ASPDH_uc002psr.3_5'Flank	NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	684	Cytoplasmic (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GCCTTTGCCCCCGCAGCCCCC	0.627													13	19					0.000151284	0.000162005	1	0	A	51020919	A	A	51020919	3	1	60	1	0	0	0	0	1	0	0	0	9057	623	22	4	94	4	LRRC4B	19	51020919	Missense_Mutation	SNP	C	TCGA-CN-5363-01A-01D-1434-08	608277	51020919	8108064	222	12318											
ZSCAN5A	79149	broad.mit.edu	37	chr19	56733088	56733088	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaggctccccctgtaggtGaaaactttcttgcagtcttt	7	15	8	11	0	3	1	1	1	2	0	4	1	4	1	2	2	2	3	2	2	3	5			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr19:56733088G>A	uc002qmq.2	-	5	1513	c.1347C>T	c.(1345-1347)TTC>TTT	p.F449F	ZSCAN5A_uc010ygi.1_Silent_p.F332F|ZSCAN5A_uc002qmr.2_Silent_p.F449F|ZSCAN5A_uc002qms.1_Silent_p.F448F	NM_024303	NP_077279	Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	449	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CCCTGTAGGTGAAAACTTTCT	0.507													27	79					0	0	0	0	A	56733088	A	A	56733088	2	1	60	1	0	0	0	0	0	0	0	1	18305	1281	45	2		2	ZSCAN5A	19	56733088	Silent	SNP	G	TCGA-CN-5363-01A-01D-1434-08	5712169	56733088	2395895	223	12319											
CST7	8530	broad.mit.edu	37	chr20	24937978	24937978	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaggatttcctaaaacaatAaagaccaatgacccaggagt	17	7	7	10	0	0	2	0	1	0	1	1	4	1	4	4	2	1	0	4	2	6	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr20:24937978A>G	uc002wtx.1	+	2	402	c.192A>G	c.(190-192)ATA>ATG	p.I64M		NM_003650	NP_003641	O76096	CYTF_HUMAN	cystatin F	42					immune response	cytoplasm|extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1						CTAAAACAATAAAGACCAATG	0.458													97	312					0	0	0	0	G	24937978	G	G	24937978	3	3	60	1	0	0	0	0	1	0	0	0	3994	352	13	5	132	5	CST7	20	24937978	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08		24937978	38087542	224	12320											
C20orf11	54994	broad.mit.edu	37	chr20	61572952	61572952	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagacatgaaccgcctcaTcatgaactacctggtcacag	13	7	8	13	1	3	3	3	2	0	1	3	3	3	3	3	1	4	1	3	1	3	1			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr20:61572952T>A	uc002ydy.2	+	2	275	c.98T>A	c.(97-99)ATC>AAC	p.I33N		NM_017896	NP_060366	Q9NWU2	CT011_HUMAN	chromosome 20 open reading frame 11	33	LisH.					nucleus	protein binding				0	Breast(26;5.68e-08)					AACCGCCTCATCATGAACTAC	0.438													26	80					0	0	0	0	A	61572952	A	A	61572952	3	1	60	1	0	0	0	0	1	0	0	0	2089	1435	50	5	100	5	C20orf11	20	61572952	Missense_Mutation	SNP	T	TCGA-CN-5363-01A-01D-1434-08	36634974	61572952	1452568	225	12321											
MYO18B	84700	broad.mit.edu	37	chr22	26164925	26164925	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttaagtaaggcagagaagAcaggtgagcctcagacccag	14	6	12	9	0	2	4	1	1	1	3	2	5	2	4	2	2	1	2	2	2	3	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chr22:26164925A>G	uc003abz.1	+	4	1292	c.1042A>G	c.(1042-1044)ACA>GCA	p.T348A	MYO18B_uc003aca.1_Missense_Mutation_p.T229A|MYO18B_uc010guy.1_Missense_Mutation_p.T229A|MYO18B_uc010guz.1_Missense_Mutation_p.T229A|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	348						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGCAGAGAAGACAGGTGAGCC	0.547													7	18					0	0	0	0	G	26164925	G	G	26164925	3	3	60	1	0	0	0	0	1	0	0	0	10119	275	10	5	1052	5	MYO18B	22	26164925	Missense_Mutation	SNP	A	TCGA-CN-5363-01A-01D-1434-08		26164925	25139641	226	12322											
GPR143	4935	broad.mit.edu	37	chrX	9728793	9728793	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcagcaggccaaatttcCgtgtggttcatatccgagac	12	9	10	10	2	1	1	1	0	0	1	3	2	3	1	3	2	2	3	3	2	3	3			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chrX:9728793C>T	uc004cst.1	-	2	384	c.384G>A	c.(382-384)ACG>ACA	p.T128T		NM_000273	NP_000264	P51810	GP143_HUMAN	G protein-coupled receptor 143	108	Extracellular (Potential).				calcium-mediated signaling using intracellular calcium source|eye pigment biosynthetic process|melanosome organization|melanosome transport|phosphatidylinositol-mediated signaling|regulation of calcium-mediated signaling|visual perception	apical plasma membrane|Golgi apparatus|integral to membrane|lysosomal membrane|melanosome membrane|membrane fraction	dopamine binding|L-DOPA receptor activity|protein binding|tyrosine binding			ovary(1)	1		Hepatocellular(5;0.000888)				GCCAAATTTCCGTGTGGTTCA	0.448													5	4					0	0	0	0	T	9728793	T	T	9728793	2	4	60	1	0	0	0	0	0	0	0	1	6689	639	23	1		1	GPR143	23	9728793	Silent	SNP	C	TCGA-CN-5363-01A-01D-1434-08		9728793	145541767	227	12323											
FAM46D	169966	broad.mit.edu	37	chrX	79698219	79698219	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggaattattgttaaagatGccagattgaatggttccgta	14	13	10	4	1	0	3	0	1	0	2	1	4	1	4	2	2	1	3	2	2	7	6			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chrX:79698219G>C	uc004edl.1	+	5	515	c.181G>C	c.(181-183)GCC>CCC	p.A61P	FAM46D_uc004edm.1_Missense_Mutation_p.A61P	NM_152630	NP_689843	Q8NEK8	FA46D_HUMAN	hypothetical protein LOC169966	61										lung(2)	2						TGTTAAAGATGCCAGATTGAA	0.398													52	44					0	0	0	0	C	79698219	C	C	79698219	3	2	60	1	0	0	0	0	1	0	0	0	5600	1319	46	4	183	4	FAM46D	23	79698219	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	69969426	79698219	75572341	228	12324											
ZNF75D	7626	broad.mit.edu	37	chrX	134428026	134428026	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccacatagcccccatctggGggcttgagcatgaatccgcg	8	7	11	15	2	1	2	0	2	1	0	2	2	2	2	4	2	2	2	4	2	2	2			TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chrX:134428026G>T	uc004eyp.2	-	3	2696	c.41C>A	c.(40-42)CCC>CAC	p.P14H	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'Flank|ZNF75D_uc004eyo.2_Missense_Mutation_p.P14H	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	14					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCCCATCTGGGGGCTTGAGCA	0.483													114	143					8.09351e-62	1.13476e-61	1	0	T	134428026	T	T	134428026	3	4	60	1	0	0	0	0	1	0	0	0	18201	1232	43	4	1511	4	ZNF75D	23	134428026	Missense_Mutation	SNP	G	TCGA-CN-5363-01A-01D-1434-08	54729807	134428026	20842534	229	12325											
CD40LG	959	broad.mit.edu	37	chrX	135730223	135730223	+	5'Flank	DEL	C	-	-																															attaaaaaaaaaaaaaaaaaCaaaaaacctttacgtaacgt																										TCGA-CN-5363-01A-01D-1434-08	TCGA-CN-5363-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	203f8426-6ec5-427a-9ccf-ec2b4683504d	2fb4cc0c-5da0-49a7-b686-7277b4e56622	g.chrX:135730223delC	uc004faa.2	+						CD40LG_uc010nsd.2_5'Flank|CD40LG_uc010nse.1_5'Flank	NM_000074	NP_000065	P29965	CD40L_HUMAN	CD40 ligand						anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	aaaaaaaaaacaaaaaaCCTT	0.343									Immune_Deficiency_with_Hyper-IgM				---	---	---								-	135730223	-	-	135730223	6	5	60	0	1	1	0	1	0	0	0	0	3031	493	17	0		0	CD40LG	23	135730223	5'Flank	DEL	C	TCGA-CN-5363-01A-01D-1434-08	1302197	135730223	19540337	230	12326											
SPEN	23013	broad.mit.edu	37	chr1	16203019	16203019	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attaccagcacagcaggagtCggtcaccacattcatcccag	12	7	8	14	1	2	0	2	0	0	0	4	1	3	1	3	2	3	2	3	2	1	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:16203019C>A	uc001axk.1	+	3	931	c.727C>A	c.(727-729)CGG>AGG	p.R243R	SPEN_uc010obp.1_Silent_p.R202R	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	243	Ser-rich.|Arg-rich.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CAGCAGGAGTCGGTCACCACA	0.547													27	55					8.24728e-16	9.5959e-16	1	0	A	16203019	A	A	16203019	2	1	61	1	0	0	0	0	0	0	0	1	15104	875	31	3		3	SPEN	1	16203019	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08		16203019	233047602	1	12327											
AIM1L	55057	broad.mit.edu	37	chr1	26672990	26672990	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgacggctgaactcaaacatCtccttctgcggggcttccat	8	10	9	14	3	3	1	1	1	2	0	5	2	4	1	2	3	3	2	2	3	2	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:26672990C>T	uc001bmd.3	-						uc009vsi.1_Silent_p.E53E	NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like								sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		ACTCAAACATCTCCTTCTGCG	0.567													7	24					0	0	0	0	T	26672990	T	T	26672990	1	4	61	0	1	0	0	0	0	0	0	0	431	928	32	2		2	AIM1L	1	26672990	5'Flank	SNP	C	TCGA-CN-5364-01A-01D-1434-08	10469971	26672990	222577631	2	12328											
SLC9A1	6548	broad.mit.edu	37	chr1	27427043	27427043	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactttgcccttcagctcttCattcaccaggtccacagact	8	12	6	15	0	4	1	3	0	1	1	5	2	5	1	3	1	2	1	3	1	0	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:27427043C>A	uc001bnm.2	-	12	2829	c.2203G>T	c.(2203-2205)GAA>TAA	p.E735*	SLC9A1_uc001bnl.2_Nonsense_Mutation_p.E239*|SLC9A1_uc010ofk.1_Nonsense_Mutation_p.E396*	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	735	Cytoplasmic (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	TTCAGCTCTTCATTCACCAGG	0.607													111	325					5.55186e-77	6.8473e-77	1	0	A	27427043	A	A	27427043	4	1	61	1	0	0	0	0	0	1	0	0	14773	835	29	2	248	2	SLC9A1	1	27427043	Nonsense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	754053	27427043	221823578	3	12329											
LCK	3932	broad.mit.edu	37	chr1	32739961	32739961	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgcagctcacacccggaaGatgactggatggaaaacatc	13	6	11	11	1	1	2	1	1	0	1	2	5	1	5	1	3	3	3	1	3	3	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:32739961G>A	uc001bux.2	+	2	169	c.31G>A	c.(31-33)GAT>AAT	p.D11N	LCK_uc001buy.2_Missense_Mutation_p.D11N|LCK_uc001buz.2_Missense_Mutation_p.D11N|LCK_uc010ohc.1_Missense_Mutation_p.D55N|LCK_uc001bva.2_Missense_Mutation_p.D11N	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	11	Interactions with CD4 and CD8 (By similarity).				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	ACACCCGGAAGATGACTGGAT	0.567			T	TRB@	T-ALL								11	83					0	0	0	0	A	32739961	A	A	32739961	3	1	61	1	0	0	0	0	1	0	0	0	8716	942	33	2	33	2	LCK	1	32739961	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	5312918	32739961	216510660	4	12330											
LCK	3932	broad.mit.edu	37	chr1	32740021	32740021	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attatcccatagtcccactgGatggcaagggcacggtaaga	12	8	11	10	1	0	1	0	0	0	1	2	2	2	2	2	4	0	3	2	4	4	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:32740021G>T	uc001bux.2	+	2	229	c.91G>T	c.(91-93)GAT>TAT	p.D31Y	LCK_uc001buy.2_Missense_Mutation_p.D31Y|LCK_uc001buz.2_Missense_Mutation_p.D31Y|LCK_uc010ohc.1_Missense_Mutation_p.D75Y|LCK_uc001bva.2_Missense_Mutation_p.D31Y	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	31	Interactions with CD4 and CD8 (By similarity).				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	AGTCCCACTGGATGGCAAGGG	0.552			T	TRB@	T-ALL								9	72					1.76689e-08	1.98106e-08	1	0	T	32740021	T	T	32740021	3	4	61	1	0	0	0	0	1	0	0	0	8716	1174	41	2	93	2	LCK	1	32740021	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	60	32740021	216510600	5	12331											
LCK	3932	broad.mit.edu	37	chr1	32745441	32745441	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatctgtgtttggcctgcaGattgcagaaggcatggcatt	8	13	13	7	0	1	3	0	1	1	2	1	3	1	3	1	3	2	5	1	3	1	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:32745441G>A	uc001bux.2	+	11	1180	c.1042_splice	c.e11-1	p.I348_splice	LCK_uc001buy.2_Splice_Site_p.I348_splice|LCK_uc001buz.2_Splice_Site_p.I378_splice|LCK_uc010ohc.1_Splice_Site_p.I392_splice|LCK_uc001bva.2_Splice_Site_p.I355_splice	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase						activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	TTGGCCTGCAGATTGCAGAAG	0.542			T	TRB@	T-ALL								20	142					0	0	0	0	A	32745441	A	A	32745441	5	1	61	1	0	0	0	0	0	0	1	0	8716	956	33	2	1079	2	LCK	1	32745441	Splice_Site	SNP	G	TCGA-CN-5364-01A-01D-1434-08	5420	32745441	216505180	6	12332											
PPCS	79717	broad.mit.edu	37	chr1	42925463	42925463	+	Frame_Shift_Del	DEL	T	-	-																															agtcacgacagtcctttgtgTttattgtaaccaaagactcg																										TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:42925463delT	uc001chl.2	+	3	866	c.802delT	c.(802-804)TTTfs	p.F268fs	PPCS_uc001chk.2_Frame_Shift_Del_p.F95fs	NM_024664	NP_078940	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase isoform	268					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GTCCTTTGTGTTTATTGTAAC	0.408													---	---	---								-	42925463	-	-	42925463	7	5	61	1	0	1	0	1	0	0	0	0	12360	1725	60	0	812	0	PPCS	1	42925463	Frame_Shift_Del	DEL	T	TCGA-CN-5364-01A-01D-1434-08	10180022	42925463	206325158	7	12333											
PTPRF	5792	broad.mit.edu	37	chr1	44058140	44058140	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcccagcacaaggtgaccTtcgacccaacctcctcctac	9	8	5	19	1	0	1	0	1	0	0	4	2	3	1	6	1	3	1	6	1	3	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:44058140T>C	uc001cjr.2	+	11	2021	c.1681T>C	c.(1681-1683)TTC>CTC	p.F561L	PTPRF_uc001cjs.2_Missense_Mutation_p.F561L|PTPRF_uc001cju.2_Missense_Mutation_p.F132L|PTPRF_uc009vwt.2_Missense_Mutation_p.F132L|PTPRF_uc001cjv.2_Missense_Mutation_p.F132L	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	561	Extracellular (Potential).|Fibronectin type-III 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CAAGGTGACCTTCGACCCAAC	0.572													50	164					0	0	0	0	C	44058140	C	C	44058140	3	2	61	1	0	0	0	0	1	0	0	0	12866	1609	56	5	1715	5	PTPRF	1	44058140	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	1132677	44058140	205192481	8	12334											
ST6GALNAC5	81849	broad.mit.edu	37	chr1	77510090	77510090	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatccagaggatcctccgcAaccgccatgacctgctcaac	10	6	8	17	2	1	2	1	1	0	1	4	3	4	3	6	1	3	3	6	1	2	0	rs34735755		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:77510090A>G	uc001dhi.2	+	3	638	c.463A>G	c.(463-465)AAC>GAC	p.N155D	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	155	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						GATCCTCCGCAACCGCCATGA	0.637													15	58					0	0	0	0	G	77510090	G	G	77510090	3	3	61	1	0	0	0	0	1	0	0	0	15293	130	5	5	473	5	ST6GALNAC5	1	77510090	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	33451950	77510090	171740531	9	12335											
BCAR3	8412	broad.mit.edu	37	chr1	94037258	94037258	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagggctttcatgagagctGagaaggaatagaggtccccc	11	7	13	10	0	1	3	1	2	0	3	2	6	2	4	3	3	1	2	3	3	3	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:94037258G>C	uc001dpz.2	-	9	2218	c.1943C>G	c.(1942-1944)TCA>TGA	p.S648*	BCAR3_uc001dqa.2_Nonsense_Mutation_p.S648*|BCAR3_uc001dqb.2_Nonsense_Mutation_p.S648*|BCAR3_uc001dpx.3_Nonsense_Mutation_p.S324*|BCAR3_uc001dpy.2_Nonsense_Mutation_p.S557*|BCAR3_uc009wdm.1_Nonsense_Mutation_p.S324*	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	648	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CATGAGAGCTGAGAAGGAATA	0.478													25	128					0	0	0	0	C	94037258	C	C	94037258	4	2	61	1	0	0	0	0	0	1	0	0	1351	1294	45	2	550	2	BCAR3	1	94037258	Nonsense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	16527168	94037258	155213363	10	12336											
OLFM3	118427	broad.mit.edu	37	chr1	102270141	102270141	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacaatattgcctgcattctGgttagttgcatacacagccc	10	12	8	11	0	1	0	0	0	1	0	1	1	1	0	2	1	5	4	2	1	4	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:102270141G>A	uc001duf.2	-	6	1161	c.1090C>T	c.(1090-1092)CAG>TAG	p.Q364*	OLFM3_uc001dug.2_Nonsense_Mutation_p.Q344*|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Nonsense_Mutation_p.Q269*|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	364	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CCTGCATTCTGGTTAGTTGCA	0.483													11	68					0	0	0	0	A	102270141	A	A	102270141	4	1	61	1	0	0	0	0	0	1	0	0	10908	1357	47	4	350	4	OLFM3	1	102270141	Nonsense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	8232883	102270141	146980480	11	12337											
WDR47	22911	broad.mit.edu	37	chr1	109554265	109554265	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaaagcaaacagagcttacTatagtcatctttagaaggac	17	9	7	8	0	2	2	1	0	1	2	2	3	2	3	0	1	4	2	0	1	8	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:109554265T>C	uc001dwj.2	-	5	779	c.403A>G	c.(403-405)AGT>GGT	p.S135G	WDR47_uc001dwl.2_Missense_Mutation_p.S142G|WDR47_uc001dwi.2_Missense_Mutation_p.S135G|WDR47_uc001dwk.2_Missense_Mutation_p.S107G|WDR47_uc010ovf.1_Missense_Mutation_p.S62G	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	135										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		CAGAGCTTACTATAGTCATCT	0.408													44	180					0	0	0	0	C	109554265	C	C	109554265	3	2	61	1	0	0	0	0	1	0	0	0	17368	1522	53	5	2403	5	WDR47	1	109554265	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	7284124	109554265	139696356	12	12338											
MRPL9	65005	broad.mit.edu	37	chr1	151734860	151734860	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctttgagctcaccaatttctCctcttcaaacagcttcttgt	8	16	4	13	0	5	1	2	1	3	0	6	1	5	1	2	0	3	2	2	0	2	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:151734860C>A	uc001eyv.2	-	3	512	c.427G>T	c.(427-429)GAG>TAG	p.E143*	MRPL9_uc009wmz.2_RNA|MRPL9_uc010pdk.1_Nonsense_Mutation_p.E143*|MRPL9_uc009wna.1_3'UTR	NM_031420	NP_113608	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9 precursor	143					translation	mitochondrial ribosome	structural constituent of ribosome			ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACCAATTTCTCCTCTTCAAAC	0.438													40	158					3.43241e-23	4.17761e-23	1	0	A	151734860	A	A	151734860	4	1	61	1	0	0	0	0	0	1	0	0	9873	864	30	2	396	2	MRPL9	1	151734860	Nonsense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	42180595	151734860	97515761	13	12339											
OR10T2	128360	broad.mit.edu	37	chr1	158368589	158368589	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatcttcaggatggtgttaActatgaagccataggatatg	12	12	12	5	0	2	1	1	1	1	0	2	4	2	4	1	4	2	1	1	4	5	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:158368589A>G	uc010pih.1	-	1	668	c.668T>C	c.(667-669)GTT>GCT	p.V223A		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GATGGTGTTAACTATGAAGCC	0.473													7	47					0	0	0	0	G	158368589	G	G	158368589	3	3	61	1	0	0	0	0	1	0	0	0	10973	43	2	5	278	5	OR10T2	1	158368589	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	6633729	158368589	90882032	14	12340											
BAT2L2	23215	broad.mit.edu	37	chr1	171506560	171506560	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagatccctatcctcatgctGagcctcaacaagcaactact	12	9	5	15	0	2	2	2	1	0	1	4	2	4	2	3	0	6	2	3	0	5	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:171506560G>C	uc010pmg.1	+	15	2712	c.2446G>C	c.(2446-2448)GAG>CAG	p.E816Q	BAT2L2_uc010pmh.1_5'Flank	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	816							protein C-terminus binding				0						TCCTCATGCTGAGCCTCAACA	0.408													2	8					0	0	0	0	C	171506560	C	C	171506560	3	2	61	1	0	0	0	0	1	0	0	0	1323	1291	45	2	2500	2	BAT2L2	1	171506560	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	13137971	171506560	77744061	15	12341											
PAPPA2	60676	broad.mit.edu	37	chr1	176564125	176564125	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgacagcgagctttgagcCtgtgaacacagagtgggttc	9	9	13	10	1	0	4	0	3	0	1	1	5	0	4	2	1	4	2	2	1	1	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:176564125C>T	uc001gkz.2	+	3	2549	c.1385C>T	c.(1384-1386)CCT>CTT	p.P462L	PAPPA2_uc001gky.1_Missense_Mutation_p.P462L|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	462	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGCTTTGAGCCTGTGAACACA	0.542													24	111					0	0	0	0	T	176564125	T	T	176564125	3	4	61	1	0	0	0	0	1	0	0	0	11487	681	24	4	1391	4	PAPPA2	1	176564125	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	5057565	176564125	72686496	16	12342											
HMCN1	83872	broad.mit.edu	37	chr1	186039757	186039757	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgcagttccacccataatCaataaaggggacctttgggg	12	10	10	9	0	1	0	1	0	0	0	2	1	2	1	3	4	1	2	3	4	5	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:186039757C>T	uc001grq.1	+	52	8236	c.8007C>T	c.(8005-8007)ATC>ATT	p.I2669I		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2669	Ig-like C2-type 25.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CACCCATAATCAATAAAGGGG	0.373													25	110					0	0	0	0	T	186039757	T	T	186039757	2	4	61	1	0	0	0	0	0	0	0	1	7259	816	29	2		2	HMCN1	1	186039757	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08	9475632	186039757	63210864	17	12343											
KDM5B	10765	broad.mit.edu	37	chr1	202724420	202724420	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtgcaagtagttaattgaaTagctccagtggtcttcaatg	12	13	10	6	0	2	1	1	1	1	0	3	1	3	1	1	1	2	4	1	1	6	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:202724420T>A	uc001gyf.2	-	11	1633	c.1517A>T	c.(1516-1518)TAT>TTT	p.Y506F	KDM5B_uc009xag.2_Missense_Mutation_p.Y542F|KDM5B_uc001gyg.1_Missense_Mutation_p.Y348F	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	506	JmjC.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						GTTAATTGAATAGCTCCAGTG	0.403													32	92					0	0	0	0	A	202724420	A	A	202724420	3	1	61	1	0	0	0	0	1	0	0	0	8173	1406	49	5	3185	5	KDM5B	1	202724420	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	16684663	202724420	46526201	18	12344											
TLR5	7100	broad.mit.edu	37	chr1	223284063	223284063	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgggcataactgaaggCttcaaggcaccagccatctc	10	7	10	14	0	2	1	1	1	1	0	3	1	2	1	3	3	2	3	3	3	3	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:223284063C>T	uc001hnv.1	-	4	2757	c.2311G>A	c.(2311-2313)GCC>ACC	p.A771T	TLR5_uc001hnw.1_Missense_Mutation_p.A771T	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	771	Cytoplasmic (Potential).|TIR.		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		TAACTGAAGGCTTCAAGGCAC	0.483													11	45					0	0	0	0	T	223284063	T	T	223284063	3	4	61	1	0	0	0	0	1	0	0	0	16020	797	28	4	269	4	TLR5	1	223284063	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	20559643	223284063	25966558	19	12345											
TMEM63A	9725	broad.mit.edu	37	chr1	226047034	226047035	+	Frame_Shift_Ins	INS	-	A	A																															gccaccagcggaggccctggINSatagagaggttcttcctgca																										TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:226047034_226047035insA	uc001hpm.1	-	15	1488_1489	c.1238_1239insT	c.(1237-1239)ATCfs	p.I413fs		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	413						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					GGAGGCCCTGGATAGAGAGGTT	0.574													---	---	---								A	226047035	A	A	226047034	7	5	61	1	0	1	1	0	0	0	0	0	16256	1164	41	0	1224	0	TMEM63A	1	226047034	Frame_Shift_Ins	INS	-	TCGA-CN-5364-01A-01D-1434-08	2762971	226047034	23203587	20	12346											
EXOC8	149371	broad.mit.edu	37	chr1	231472440	231472440	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaccgccccttcaaagtctCtctgcgcaatgcagacatcc	10	8	6	17	2	3	1	1	0	2	1	5	1	4	1	4	0	3	2	4	0	3	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:231472440C>T	uc001huq.2	-	1	1139	c.1052G>A	c.(1051-1053)AGA>AAA	p.R351K		NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	351					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				TTCAAAGTCTCTCTGCGCAAT	0.498													28	132					0	0	0	0	T	231472440	T	T	231472440	3	4	61	1	0	0	0	0	1	0	0	0	5335	913	32	2	1129	2	EXOC8	1	231472440	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	5425406	231472440	17778181	21	12347											
FMN2	56776	broad.mit.edu	37	chr1	240493979	240493979	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caactacatgaatggaggaaAtaagactcgaggacaggcag	17	5	12	7	1	0	2	0	1	0	1	1	6	0	5	0	4	2	1	0	4	5	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr1:240493979A>T	uc010pyd.1	+	11	4739	c.4514A>T	c.(4513-4515)AAT>ATT	p.N1505I	FMN2_uc010pye.1_Missense_Mutation_p.N1509I|FMN2_uc010pyf.1_Missense_Mutation_p.N151I|FMN2_uc010pyg.1_Missense_Mutation_p.N101I	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1505	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AATGGAGGAAATAAGACTCGA	0.403													29	93					0	0	0	0	T	240493979	T	T	240493979	3	4	61	1	0	0	0	0	1	0	0	0	5982	101	4	5	4556	5	FMN2	1	240493979	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	9021539	240493979	8756642	22	12348											
ATAD2B	54454	broad.mit.edu	37	chr2	24009039	24009039	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacttttttctgattctgatAattgacgaggtggagaaggt	10	15	12	4	1	2	4	0	3	2	1	2	7	2	4	0	3	0	0	0	3	2	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:24009039A>T	uc002rek.3	-	21	3125	c.2831T>A	c.(2830-2832)TTA>TAA	p.L944*	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Nonsense_Mutation_p.L189*|ATAD2B_uc002rej.3_Nonsense_Mutation_p.L112*	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	944	Potential.						ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATTCTGATAATTGACGAGG	0.443													9	13					0	0	0	0	T	24009039	T	T	24009039	4	4	61	1	0	0	0	0	0	1	0	0	1074	372	13	5	1577	5	ATAD2B	2	24009039	Nonsense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08		24009039	219190334	23	12349											
FBXO11	80204	broad.mit.edu	37	chr2	48035326	48035327	+	Frame_Shift_Ins	INS	-	GG	GG																															gtgtatctgtatcatgtgtaINSggctcaccagctaatgtaca																										TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:48035326_48035327insGG	uc010fbl.2	-	23	2576_2577	c.2462_2463insCC	c.(2461-2463)CCTfs	p.P821fs	FBXO11_uc002rwe.2_Frame_Shift_Ins_p.P821fs|FBXO11_uc010fbk.2_Frame_Shift_Ins_p.P329fs	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	905					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TATCATGTGTAGGCTCACCAGC	0.401													---	---	---								GG	48035327	GG	GG	48035326	7	5	61	1	0	1	1	0	0	0	0	0	5759	407	15	0	72	0	FBXO11	2	48035326	Frame_Shift_Ins	INS	-	TCGA-CN-5364-01A-01D-1434-08	24026287	48035326	195164047	24	12350											
LRRTM1	347730	broad.mit.edu	37	chr2	80530848	80530848	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcacccgctgggggcggcggGcagcatctgaaagcaggccc	7	3	17	14	3	1	1	0	1	1	0	1	1	1	1	2	5	2	5	2	5	1	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:80530848G>C	uc002sok.1	-	2	367	c.97C>G	c.(97-99)CCC>GCC	p.P33A	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	33						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GGGGCGGCGGGCAGCATCTGA	0.677										HNSCC(69;0.2)			5	20					0	0	0	0	C	80530848	C	C	80530848	3	2	61	1	0	0	0	0	1	0	0	0	9089	1203	42	4	1475	4	LRRTM1	2	80530848	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	32495522	80530848	162668525	25	12351											
ANKRD36	375248	broad.mit.edu	37	chr2	97779539	97779539	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcttgtgctcggatggcttCgcatttccccaataccccat	6	12	8	15	3	0	0	0	0	0	0	3	1	1	1	4	2	2	4	4	2	2	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:97779539C>T	uc010yva.1	+	1	307	c.63C>T	c.(61-63)TTC>TTT	p.F21F	ANKRD36_uc002sxn.2_Silent_p.F21F|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Silent_p.F21F|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	21											0						CGGATGGCTTCGCATTTCCCC	0.512													5	140					0	0	0	0	T	97779539	T	T	97779539	2	4	61	1	0	0	0	0	0	0	0	1	665	883	31	1		1	ANKRD36	2	97779539	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08	17248691	97779539	145419834	26	12352											
IWS1	55677	broad.mit.edu	37	chr2	128244226	128244226	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggcacagaatccaggatctCcaggtctaagagccctgaaa	13	6	11	11	0	2	3	0	1	2	2	4	4	3	4	3	3	1	1	3	3	3	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:128244226C>T	uc002ton.2	-	13	2534	c.2231G>A	c.(2230-2232)GGA>GAA	p.G744E		NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	744					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TCCAGGATCTCCAGGTCTAAG	0.507													5	52					0	0	0	0	T	128244226	T	T	128244226	3	4	61	1	0	0	0	0	1	0	0	0	7970	855	30	2	236	2	IWS1	2	128244226	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	30464687	128244226	114955147	27	12353											
IWS1	55677	broad.mit.edu	37	chr2	128263073	128263073	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcccattaagaagttcctCattttcagagtcactaccag	12	12	6	11	0	3	2	3	0	0	2	4	2	4	2	3	0	2	1	3	0	3	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:128263073C>G	uc002ton.2	-	3	709	c.406G>C	c.(406-408)GAG>CAG	p.E136Q	IWS1_uc010yzl.1_RNA|IWS1_uc010fma.2_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	136	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		AGAAGTTCCTCATTTTCAGAG	0.483													22	174					0	0	0	0	G	128263073	G	G	128263073	3	3	61	1	0	0	0	0	1	0	0	0	7970	835	29	2	2101	2	IWS1	2	128263073	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	18847	128263073	114936300	28	12354											
MBD5	55777	broad.mit.edu	37	chr2	149247786	149247786	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acataaatgggaatagacctCgacagagtcggggatttgga	14	8	13	6	2	0	2	0	0	0	2	2	6	0	5	1	4	0	0	1	4	4	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:149247786C>T	uc002twm.3	+	12	4874	c.3886C>T	c.(3886-3888)CGA>TGA	p.R1296*	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Nonsense_Mutation_p.R1296*|MBD5_uc002two.2_Nonsense_Mutation_p.R554*|MBD5_uc002twp.2_Nonsense_Mutation_p.R346*	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1296						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GAATAGACCTCGACAGAGTCG	0.413													6	44					0	0	0	0	T	149247786	T	T	149247786	4	4	61	1	0	0	0	0	0	1	0	0	9400	876	31	1	3912	1	MBD5	2	149247786	Nonsense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	20984713	149247786	93951587	29	12355											
MARCH7	64844	broad.mit.edu	37	chr2	160605112	160605112	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggttcaccttgaagcacaGaatgatcctcttggagctgc	9	11	11	10	0	2	3	1	2	1	1	3	4	3	4	2	2	3	3	2	2	2	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:160605112G>C	uc002uax.2	+	5	1433	c.1311G>C	c.(1309-1311)CAG>CAC	p.Q437H	MARCH7_uc010foq.2_Missense_Mutation_p.Q437H|MARCH7_uc010zcn.1_Missense_Mutation_p.Q381H|MARCH7_uc010for.2_Missense_Mutation_p.Q399H|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	437							ligase activity|zinc ion binding				0						TTGAAGCACAGAATGATCCTC	0.448													5	147					0	0	0	0	C	160605112	C	C	160605112	3	2	61	1	0	0	0	0	1	0	0	0	9359	933	33	2	1325	2	MARCH7	2	160605112	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	11357326	160605112	82594261	30	12356											
SCN9A	6335	broad.mit.edu	37	chr2	167141152	167141152	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttactgctgcgtcgctcCtggggtctgtggggcacaaa	6	11	14	10	2	1	0	0	0	1	0	3	0	2	0	1	4	3	4	1	4	2	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:167141152C>T	uc010fpl.2	-	12	2126	c.1785G>A	c.(1783-1785)CAG>CAA	p.Q595Q	uc002udp.2_Intron|SCN9A_uc002udr.1_Silent_p.Q466Q|SCN9A_uc002uds.1_Silent_p.Q466Q|SCN9A_uc002udt.1_Silent_p.Q466Q	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	595						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGCGTCGCTCCTGGGGTCTGT	0.537													17	75					0	0	0	0	T	167141152	T	T	167141152	2	4	61	1	0	0	0	0	0	0	0	1	13990	680	24	4		4	SCN9A	2	167141152	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08	6536040	167141152	76058221	31	12357											
HOXD3	3232	broad.mit.edu	37	chr2	177036256	177036256	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgcccaggagagagctgcGaggacaagagcccgccaggc	10	2	15	14	2	0	2	0	0	0	2	0	6	0	4	4	3	4	1	4	3	1	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:177036256G>A	uc002ukt.1	+	3	729	c.553G>A	c.(553-555)GAG>AAG	p.E185K		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	185					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		AGAGAGCTGCGAGGACAAGAG	0.627													5	33					0	0	0	0	A	177036256	A	A	177036256	3	1	61	1	0	0	0	0	1	0	0	0	7362	1059	37	1	559	1	HOXD3	2	177036256	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	9895104	177036256	66163117	32	12358											
SSFA2	6744	broad.mit.edu	37	chr2	182765561	182765561	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatcctttgccaaagggatAgatattaaagtatttttgag	13	15	8	5	0	1	2	1	1	0	1	2	3	2	3	2	1	1	1	2	1	6	7			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:182765561A>G	uc002uoi.2	+	7	964	c.642A>G	c.(640-642)ATA>ATG	p.I214M	SSFA2_uc002uoh.2_Missense_Mutation_p.I214M|SSFA2_uc002uoj.2_Missense_Mutation_p.I214M|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.I61M|SSFA2_uc002uol.2_Missense_Mutation_p.I61M	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	214						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			CCAAAGGGATAGATATTAAAG	0.308													20	71					0	0	0	0	G	182765561	G	G	182765561	3	3	61	1	0	0	0	0	1	0	0	0	15249	410	15	5	668	5	SSFA2	2	182765561	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	5729305	182765561	60433812	33	12359											
ITGAV	3685	broad.mit.edu	37	chr2	187455218	187455218	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagggaagttacttcggcttCgccgtggatttcttcgtgcc	5	13	13	10	4	1	0	0	0	1	0	4	3	1	2	2	3	2	2	2	3	2	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:187455218C>T	uc002upq.2	+	1	429	c.153C>T	c.(151-153)TTC>TTT	p.F51F	ITGAV_uc010frs.2_Silent_p.F51F	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	51	FG-GAP 1.|Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		ACTTCGGCTTCGCCGTGGATT	0.637													15	50					0	0	0	0	T	187455218	T	T	187455218	2	4	61	1	0	0	0	0	0	0	0	1	7927	883	31	1		1	ITGAV	2	187455218	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08	4689657	187455218	55744155	34	12360											
DNAH7	56171	broad.mit.edu	37	chr2	196822095	196822095	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagctgaaaatgggctccaGatacagccacgtggcttgga	12	7	13	9	1	0	3	0	1	0	2	1	4	1	4	2	3	3	3	2	3	3	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:196822095G>C	uc002utj.3	-	19	3069	c.2968C>G	c.(2968-2970)CTG>GTG	p.L990V		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	990	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATGGGCTCCAGATACAGCCAC	0.483													4	105					0	0	0	0	C	196822095	C	C	196822095	3	2	61	1	0	0	0	0	1	0	0	0	4628	933	33	2	9294	2	DNAH7	2	196822095	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	9366877	196822095	46377278	35	12361											
SATB2	23314	broad.mit.edu	37	chr2	200246428	200246428	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aacacccacctttgtaattgGattttcaacgtcacaacatg	13	12	5	11	1	2	0	2	0	0	0	2	1	2	1	2	1	3	1	2	1	4	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:200246428G>C	uc002uuy.1	-	4	1279	c.462C>G	c.(460-462)ATC>ATG	p.I154M	SATB2_uc010fsq.1_Intron|SATB2_uc002uuz.1_Missense_Mutation_p.I154M|SATB2_uc002uva.1_Missense_Mutation_p.I154M	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	154						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTTGTAATTGGATTTTCAACG	0.473													5	137					0	0	0	0	C	200246428	C	C	200246428	3	2	61	1	0	0	0	0	1	0	0	0	13919	1164	41	2	1771	2	SATB2	2	200246428	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	3424333	200246428	42952945	36	12362											
C2orf60	129450	broad.mit.edu	37	chr2	200801155	200801155	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atataaatactgggcatctcGaggactgaagagtacaacac	16	8	9	8	1	1	2	0	1	1	1	2	4	1	3	0	2	3	2	0	2	7	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:200801155G>C	uc002uvi.3	-	6	813	c.547C>G	c.(547-549)CGA>GGA	p.R183G	C2orf60_uc002uvj.3_Missense_Mutation_p.R20G|C2orf60_uc002uvk.3_Intron|C2orf60_uc010fss.2_Missense_Mutation_p.R20G	NM_001039693	NP_001034782	A2RUC4	TYW5_HUMAN	hypothetical protein LOC129450	183	JmjC.				wybutosine biosynthetic process		iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein homodimerization activity|tRNA binding				0						TGGGCATCTCGAGGACTGAAG	0.299													6	213					0	0	0	0	C	200801155	C	C	200801155	3	2	61	1	0	0	0	0	1	0	0	0	2189	1066	37	3	412	3	C2orf60	2	200801155	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	554727	200801155	42398218	37	12363											
CLK1	1195	broad.mit.edu	37	chr2	201726073	201726073	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttctgataccggctttcaTggtctctttggcgatgtcca	5	15	11	10	2	3	1	1	1	2	0	5	2	4	1	2	4	1	2	2	4	1	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:201726073T>A	uc002uwe.2	-	3	459	c.278A>T	c.(277-279)CAT>CTT	p.H93L	CLK1_uc010zhi.1_Missense_Mutation_p.H135L|CLK1_uc002uwf.2_5'UTR|CLK1_uc002uwg.2_5'UTR|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	93					cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						CCGGCTTTCATGGTCTCTTTG	0.408													68	226					0	0	0	0	A	201726073	A	A	201726073	3	1	61	1	0	0	0	0	1	0	0	0	3551	1464	51	5	1220	5	CLK1	2	201726073	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	924918	201726073	41473300	38	12364											
TTLL4	9654	broad.mit.edu	37	chr2	219602407	219602407	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtgggcccctcatggcctCagcaggaacacagcactata	11	7	10	13	0	2	0	2	0	0	0	2	1	2	1	3	3	3	2	3	3	3	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:219602407C>T	uc002viy.2	+	3	378	c.8C>T	c.(7-9)TCA>TTA	p.S3L	TTLL4_uc010zkl.1_Intron|TTLL4_uc010fvx.2_Missense_Mutation_p.S3L	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	3					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		CTCATGGCCTCAGCAGGAACA	0.572													8	71					0	0	0	0	T	219602407	T	T	219602407	3	4	61	1	0	0	0	0	1	0	0	0	16797	838	29	2	10	2	TTLL4	2	219602407	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	17876334	219602407	23596966	39	12365											
SPHKAP	80309	broad.mit.edu	37	chr2	228881860	228881860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atctgctgtctggcatggacGactgtctgtggcacactggg	6	11	14	10	1	3	0	0	0	3	0	3	2	3	1	0	4	1	3	0	4	0	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr2:228881860G>A	uc002vpq.2	-	7	3757	c.3710C>T	c.(3709-3711)TCG>TTG	p.S1237L	SPHKAP_uc002vpp.2_Missense_Mutation_p.S1237L|SPHKAP_uc010zlx.1_Missense_Mutation_p.S1237L	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1237						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGGCATGGACGACTGTCTGTG	0.562													29	133					0	0	0	0	A	228881860	A	A	228881860	3	1	61	1	0	0	0	0	1	0	0	0	15114	1059	37	1	1416	1	SPHKAP	2	228881860	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	9279453	228881860	14317513	40	12366											
BAP1	8314	broad.mit.edu	37	chr3	52437288	52437288	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccttggattggtctgaTggagggcgaggaacccttcc	6	10	15	10	1	1	1	0	1	1	0	2	5	2	4	3	5	2	1	3	5	1	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:52437288T>G	uc003ddx.2	-	14	1871	c.1756A>C	c.(1756-1758)ATC>CTC	p.I586L	BAP1_uc003ddw.2_RNA|BAP1_uc010hmg.2_RNA|BAP1_uc010hmh.2_Intron	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	586					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		ATTGGTCTGATGGAGGGCGAG	0.597			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								17	36					0	0	0	0	G	52437288	G	G	52437288	3	3	61	1	0	0	0	0	1	0	0	0	1313	1464	51	5	449	5	BAP1	3	52437288	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08		52437288	145585142	41	12367											
ARL13B	200894	broad.mit.edu	37	chr3	93714788	93714788	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcaaagggaatccaaggaGgtaagctgaaaacatttatg	17	7	11	6	0	0	1	0	1	0	0	1	3	1	3	1	3	3	3	1	3	7	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:93714788G>A	uc003drc.2	+	2	416	c.130G>A	c.(130-132)GAA>AAA	p.E44K	ARL13B_uc010hop.2_Silent_p.E13E|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_5'UTR|ARL13B_uc003drf.2_Missense_Mutation_p.E44K|ARL13B_uc003drg.2_Intron	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	44							GTP binding				0						AATCCAAGGAGGTAAGCTGAA	0.299													16	28					0	0	0	0	A	93714788	A	A	93714788	3	1	61	1	0	0	0	0	1	0	0	0	929	1014	35	4	136	4	ARL13B	3	93714788	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	41277500	93714788	104307642	42	12368											
STX19	415117	broad.mit.edu	37	chr3	93733390	93733390	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttgatgctctctccttgttCctctactaaaagagatatct	9	16	6	10	0	3	2	0	1	3	1	6	3	5	2	2	0	2	3	2	0	4	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:93733390C>T	uc003drh.1	-	2	981	c.724G>A	c.(724-726)GAA>AAA	p.E242K	ARL13B_uc003drc.2_Intron|ARL13B_uc010hop.2_Intron|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_Intron|ARL13B_uc003drf.2_Intron|ARL13B_uc003drg.2_Intron	NM_001001850	NP_001001850	Q8N4C7	STX19_HUMAN	syntaxin 19	242	t-SNARE coiled-coil homology.				intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity				0						TCTCCTTGTTCCTCTACTAAA	0.318													6	56					0	0	0	0	T	93733390	T	T	93733390	3	4	61	1	0	0	0	0	1	0	0	0	15408	864	30	2	164	2	STX19	3	93733390	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	18602	93733390	104289040	43	12369											
BBX	56987	broad.mit.edu	37	chr3	107517519	107517519	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaaccaagattacacacCttgtcaggacagcagatggc	15	6	10	10	0	1	2	1	0	0	2	1	4	1	4	2	3	3	1	2	3	4	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:107517519C>T	uc010hpr.2	+	16	2830	c.2503C>T	c.(2503-2505)CTT>TTT	p.L835F	BBX_uc003dwk.3_Missense_Mutation_p.L805F|BBX_uc003dwl.3_Silent_p.T498T|BBX_uc003dwm.3_Missense_Mutation_p.L805F|BBX_uc003dwo.3_Silent_p.T154T	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	835					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GATTACACACCTTGTCAGGAC	0.398													3	70					0	0	0	0	T	107517519	T	T	107517519	3	4	61	1	0	0	0	0	1	0	0	0	1345	681	24	4	2553	4	BBX	3	107517519	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	13784129	107517519	90504911	44	12370											
LSAMP	4045	broad.mit.edu	37	chr3	115529219	115529219	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccagcagccacagtggtacgGccagactgatggatccattt	10	8	11	12	1	0	2	0	1	0	1	1	3	1	3	4	3	3	2	4	3	1	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:115529219G>A	uc003ebt.2	-	7	1462	c.962C>T	c.(961-963)GCC>GTC	p.A321V	LSAMP_uc011bis.1_Missense_Mutation_p.A344V	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	321					cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CAGTGGTACGGCCAGACTGAT	0.423													13	21					0	0	0	0	A	115529219	A	A	115529219	3	1	61	1	0	0	0	0	1	0	0	0	9098	1203	42	4	58	4	LSAMP	3	115529219	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	8011700	115529219	82493211	45	12371											
ATP2C1	27032	broad.mit.edu	37	chr3	130718428	130718428	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctatgcagttcttggatccAtcatgggacaattactagtt	10	14	9	8	0	2	0	1	0	1	0	3	2	3	2	1	2	2	4	1	2	4	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:130718428A>C	uc003enl.2	+	27	2776	c.2554A>C	c.(2554-2556)ATC>CTC	p.I852L	ATP2C1_uc011blg.1_Missense_Mutation_p.I886L|ATP2C1_uc011blh.1_Missense_Mutation_p.I847L|ATP2C1_uc011bli.1_Missense_Mutation_p.I886L|ATP2C1_uc003enk.2_Missense_Mutation_p.I836L|ATP2C1_uc003enm.2_Missense_Mutation_p.I852L|ATP2C1_uc003enn.2_Missense_Mutation_p.I836L|ATP2C1_uc003eno.2_Missense_Mutation_p.I852L|ATP2C1_uc003enp.2_Missense_Mutation_p.I852L|ATP2C1_uc003enq.2_Missense_Mutation_p.I852L|ATP2C1_uc003enr.2_Missense_Mutation_p.I852L|ATP2C1_uc003ens.2_Missense_Mutation_p.I852L|ATP2C1_uc003ent.2_Missense_Mutation_p.I852L|ATP2C1_uc003enu.2_Missense_Mutation_p.I530L	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	852	Helical; Name=9; (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TCTTGGATCCATCATGGGACA	0.393									Hailey-Hailey_disease				21	123					0	0	0	0	C	130718428	C	C	130718428	3	2	61	1	0	0	0	0	1	0	0	0	1145	217	8	5	2656	5	ATP2C1	3	130718428	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	15189209	130718428	67304002	46	12372											
AADACL2	344752	broad.mit.edu	37	chr3	151451836	151451836	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggatattatggggctaaaaGctctctgtttggggctgctt	7	14	14	6	0	1	0	0	0	1	0	2	1	1	1	0	5	2	5	0	5	4	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:151451836G>A	uc003ezc.2	+	1	133	c.13G>A	c.(13-15)GCT>ACT	p.A5T	AADACL2_uc010hvn.2_5'UTR	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	5						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GGGGCTAAAAGCTCTCTGTTT	0.383													4	45					0	0	0	0	A	151451836	A	A	151451836	3	1	61	1	0	0	0	0	1	0	0	0	11	971	34	4	15	4	AADACL2	3	151451836	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	20733408	151451836	46570594	47	12373											
SLC7A14	57709	broad.mit.edu	37	chr3	170198764	170198764	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttgacaaaaccatcaatgTcactctcaggttggtatcga	13	11	7	10	1	3	1	3	1	1	0	5	2	3	1	1	2	1	2	1	2	4	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:170198764T>C	uc003fgz.2	-	7	1623	c.1307A>G	c.(1306-1308)GAC>GGC	p.D436G	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	436						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			ACCATCAATGTCACTCTCAGG	0.498													18	115					0	0	0	0	C	170198764	C	C	170198764	3	2	61	1	0	0	0	0	1	0	0	0	14760	1667	58	5	1016	5	SLC7A14	3	170198764	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	18746928	170198764	27823666	48	12374											
TNIK	23043	broad.mit.edu	37	chr3	170802049	170802049	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggttgggtttacatttaccaCcgaaatctttcttgcttcat	8	17	7	9	1	3	0	1	0	2	0	3	1	3	0	2	2	3	3	2	2	3	8			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:170802049C>A	uc003fhh.2	-	26	3409	c.3064G>T	c.(3064-3066)GTG>TTG	p.V1022L	TNIK_uc003fhi.2_Missense_Mutation_p.V967L|TNIK_uc003fhj.2_Missense_Mutation_p.V993L|TNIK_uc003fhk.2_Missense_Mutation_p.V1014L|TNIK_uc003fhl.2_Missense_Mutation_p.V938L|TNIK_uc003fhm.2_Missense_Mutation_p.V959L|TNIK_uc003fhn.2_Missense_Mutation_p.V985L|TNIK_uc003fho.2_Missense_Mutation_p.V930L|TNIK_uc003fhg.2_Missense_Mutation_p.V200L|TNIK_uc003fhp.2_5'Flank	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1022	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			ACATTTACCACCGAAATCTTT	0.403													12	190					0.00136819	0.001422	1	0	A	170802049	A	A	170802049	3	1	61	1	0	0	0	0	1	0	0	0	16379	507	18	4	1050	4	TNIK	3	170802049	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	603285	170802049	27220381	49	12375											
ECT2	1894	broad.mit.edu	37	chr3	172482216	172482216	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaccccgtaagcgcccatCagctgagcattccctttcca	8	9	6	18	2	1	1	1	1	0	0	4	1	4	1	6	0	3	3	6	0	1	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:172482216C>T	uc003fii.2	+	11	1262	c.1124C>T	c.(1123-1125)TCA>TTA	p.S375L	ECT2_uc010hwv.1_Missense_Mutation_p.S406L|ECT2_uc003fih.2_Missense_Mutation_p.S374L|ECT2_uc003fij.1_Missense_Mutation_p.S375L|ECT2_uc003fik.1_Missense_Mutation_p.S375L|ECT2_uc003fil.1_Missense_Mutation_p.S406L	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	375					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AAGCGCCCATCAGCTGAGCAT	0.453													6	191					0	0	0	0	T	172482216	T	T	172482216	3	4	61	1	0	0	0	0	1	0	0	0	4923	838	29	2	1162	2	ECT2	3	172482216	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	1680167	172482216	25540214	50	12376											
MAP3K13	9175	broad.mit.edu	37	chr3	185191117	185191117	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggacaggacatagcaacctgCgccaacaacctgaggtattt	13	7	10	11	1	0	1	0	1	0	0	0	3	0	3	3	3	5	2	3	3	5	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:185191117C>T	uc010hyf.2	+	12	2264	c.1998C>T	c.(1996-1998)TGC>TGT	p.C666C	MAP3K13_uc011brt.1_Silent_p.C459C|MAP3K13_uc011bru.1_Silent_p.C522C|MAP3K13_uc003fpi.2_Silent_p.C666C|MAP3K13_uc010hyg.2_Silent_p.C356C	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	666					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TAGCAACCTGCGCCAACAACC	0.587													123	173					0	0	0	0	T	185191117	T	T	185191117	2	4	61	1	0	0	0	0	0	0	0	1	9300	776	27	1		1	MAP3K13	3	185191117	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08	12708901	185191117	12831313	51	12377											
LPP	4026	broad.mit.edu	37	chr3	188590462	188590462	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgcgatgttctgtgtgcaagGagcctattatgccagccccg	7	10	12	12	3	1	0	0	0	1	0	1	2	1	1	4	1	4	2	4	1	3	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:188590462G>T	uc003frs.1	+	10	1867	c.1621G>T	c.(1621-1623)GAG>TAG	p.E541*	LPP_uc011bsg.1_Nonsense_Mutation_p.E394*|LPP_uc011bsi.1_Nonsense_Mutation_p.E541*|LPP_uc011bsj.1_Nonsense_Mutation_p.E378*	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	541	LIM zinc-binding 3.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		TGTGTGCAAGGAGCCTATTAT	0.532			T	HMGA2|MLL|C12orf9	lipoma|leukemia								9	154					2.80697e-09	3.1664e-09	1	0	T	188590462	T	T	188590462	4	4	61	1	0	0	0	0	0	1	0	0	8973	1175	41	2	1651	2	LPP	3	188590462	Nonsense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	3399345	188590462	9431968	52	12378											
TP63	8626	broad.mit.edu	37	chr3	189526287	189526287	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgacgtgtccttccagcagtCgagcaccgccaagtcggcca	8	6	11	16	5	0	0	0	0	0	0	4	2	2	0	5	1	2	2	5	1	1	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr3:189526287C>T	uc003fry.2	+	4	640	c.551C>T	c.(550-552)TCG>TTG	p.S184L	TP63_uc003frx.2_Missense_Mutation_p.S184L|TP63_uc003frz.2_Missense_Mutation_p.S184L|TP63_uc010hzc.1_Missense_Mutation_p.S184L|TP63_uc003fsa.2_Missense_Mutation_p.S90L|TP63_uc003fsb.2_Missense_Mutation_p.S90L|TP63_uc003fsc.2_Missense_Mutation_p.S90L|TP63_uc003fsd.2_Missense_Mutation_p.S90L|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_Missense_Mutation_p.S65L	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	184			S -> L (in head and neck cancer).		anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TTCCAGCAGTCGAGCACCGCC	0.627									Hay-Wells_syndrome	HNSCC(45;0.13)			19	108					0	0	0	0	T	189526287	T	T	189526287	3	4	61	1	0	0	0	0	1	0	0	0	16459	893	31	1	611	1	TP63	3	189526287	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	935825	189526287	8496143	53	12379											
CXXC4	80319	broad.mit.edu	37	chr4	105412204	105412204	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gagtgaagggctgtcatgacGatgacccctggaggtaatga	11	8	15	7	1	1	4	1	4	0	0	1	7	1	5	2	3	0	2	2	3	2	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr4:105412204G>C	uc003hxg.2	-	1	264	c.249C>G	c.(247-249)ATC>ATG	p.I83M	uc003hxh.1_RNA|CXXC4_uc010ilo.2_Intron	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	CXXC finger 4	83					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		CTGTCATGACGATGACCCCTG	0.577													27	110					0	0	0	0	C	105412204	C	C	105412204	3	2	61	1	0	0	0	0	1	0	0	0	4115	1048	37	3	355	3	CXXC4	4	105412204	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08		105412204	85742072	54	12380											
NDST4	64579	broad.mit.edu	37	chr4	115767138	115767138	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtagtattggatggtgtaggGaaaaagtccatatacctgaa	14	11	12	4	0	0	1	0	1	0	0	1	3	1	3	2	3	1	3	2	3	8	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr4:115767138G>A	uc003ibu.2	-	10	2635	c.1956C>T	c.(1954-1956)TTC>TTT	p.F652F	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	652	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATGGTGTAGGGAAAAAGTCCA	0.358													15	56					0	0	0	0	A	115767138	A	A	115767138	2	1	61	1	0	0	0	0	0	0	0	1	10312	1165	41	2		2	NDST4	4	115767138	Silent	SNP	G	TCGA-CN-5364-01A-01D-1434-08	10354934	115767138	75387138	55	12381											
FAT4	79633	broad.mit.edu	37	chr4	126402801	126402801	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgccatgttggagccttttGgtgtgaacagtctggaagta	8	13	14	6	0	1	1	0	1	1	0	1	3	1	3	2	3	3	2	2	3	3	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr4:126402801G>T	uc003ifj.3	+	15	12724	c.12724G>T	c.(12724-12726)GGT>TGT	p.G4242C	FAT4_uc011cgp.1_Missense_Mutation_p.G2483C|FAT4_uc003ifi.1_Missense_Mutation_p.G1720C	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4242	Laminin G-like 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGAGCCTTTTGGTGTGAACAG	0.433													16	74					1.5739e-10	1.78632e-10	1	0	T	126402801	T	T	126402801	3	4	61	1	0	0	0	0	1	0	0	0	5724	1348	47	4	12782	4	FAT4	4	126402801	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	10635663	126402801	64751475	56	12382											
SH3RF1	57630	broad.mit.edu	37	chr4	170042098	170042098	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccccttttctcagctctagTtcatcctctttccgaggagt	5	16	6	14	1	4	0	2	0	3	0	8	2	7	1	4	1	1	2	4	1	1	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr4:170042098T>C	uc003isa.1	-	8	1724	c.1389A>G	c.(1387-1389)GAA>GAG	p.E463E	SH3RF1_uc010irc.1_Silent_p.E163E	NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	463	SH3 3.|Interaction with AKT2 (By similarity).					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TCAGCTCTAGTTCATCCTCTT	0.418													26	73					0	0	0	0	C	170042098	C	C	170042098	2	2	61	1	0	0	0	0	0	0	0	1	14323	1722	60	5		5	SH3RF1	4	170042098	Silent	SNP	T	TCGA-CN-5364-01A-01D-1434-08	43639297	170042098	21112178	57	12383											
GLRA3	8001	broad.mit.edu	37	chr4	175710093	175710093	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtttcctttgtggcaaccaAactacaaataagaacaaaaa	18	10	5	8	0	0	1	0	0	0	1	1	1	1	1	2	1	4	2	2	1	8	4	rs144360619		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr4:175710093A>G	uc003ity.1	-	2	576	c.73T>C	c.(73-75)TTG>CTG	p.L25L	GLRA3_uc003itz.1_Silent_p.L25L	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	25					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GTGGCAACCAAACTACAAATA	0.323													7	38					0	0	0	0	G	175710093	G	G	175710093	2	3	61	1	0	0	0	0	0	0	0	1	6493	28	1	5		5	GLRA3	4	175710093	Silent	SNP	A	TCGA-CN-5364-01A-01D-1434-08	5667995	175710093	15444183	58	12384											
MCCC2	64087	broad.mit.edu	37	chr5	70930987	70930987	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatttctgcaggtcaccattGaaccttctgaagagccttta	10	14	7	10	0	3	3	1	2	2	1	3	3	3	3	3	1	3	1	3	1	4	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:70930987G>A	uc003kbs.3	+	10	1051	c.913G>A	c.(913-915)GAA>AAA	p.E305K	MCCC2_uc010iyv.1_Missense_Mutation_p.E305K|MCCC2_uc003kbt.3_RNA|MCCC2_uc003kbu.1_Missense_Mutation_p.E174K	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	305	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	GGTCACCATTGAACCTTCTGA	0.373													9	92					0	0	0	0	A	70930987	A	A	70930987	3	1	61	1	0	0	0	0	1	0	0	0	9428	1291	45	2	951	2	MCCC2	5	70930987	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08		70930987	109984273	59	12385											
ZFYVE16	9765	broad.mit.edu	37	chr5	79738953	79738953	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctttatagctcaggcatttGaaaggatgatgagtccaact	12	12	9	8	0	1	3	1	3	0	0	2	4	2	4	2	2	2	2	2	2	4	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:79738953G>A	uc003kgr.3	+	6	2733	c.2431G>A	c.(2431-2433)GAA>AAA	p.E811K	ZFYVE16_uc003kgp.2_Missense_Mutation_p.E811K|ZFYVE16_uc003kgq.3_Missense_Mutation_p.E811K|ZFYVE16_uc003kgs.3_Missense_Mutation_p.E811K|ZFYVE16_uc003kgt.3_5'UTR	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	811					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TCAGGCATTTGAAAGGATGAT	0.338													26	143					0	0	0	0	A	79738953	A	A	79738953	3	1	61	1	0	0	0	0	1	0	0	0	17731	1291	45	2	2445	2	ZFYVE16	5	79738953	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	8807966	79738953	101176307	60	12386											
APC	324	broad.mit.edu	37	chr5	112173950	112173950	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccaccactgcagcccagAttgccaaagtcatggaagaa	13	7	8	13	0	2	2	1	0	1	2	3	3	2	3	4	1	3	1	4	1	3	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:112173950A>T	uc010jby.2	+	16	3039	c.2659A>T	c.(2659-2661)ATT>TTT	p.I887F	APC_uc011cvt.1_Missense_Mutation_p.I869F|APC_uc003kpz.3_Missense_Mutation_p.I887F|APC_uc003kpy.3_Missense_Mutation_p.I887F|APC_uc010jbz.2_Missense_Mutation_p.I604F|APC_uc010jca.2_Missense_Mutation_p.I187F	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	887	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TGCAGCCCAGATTGCCAAAGT	0.468		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			16	46					0	0	0	0	T	112173950	T	T	112173950	3	4	61	1	0	0	0	0	1	0	0	0	763	333	12	5	2717	5	APC	5	112173950	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	32434997	112173950	68741310	61	12387											
MCC	4163	broad.mit.edu	37	chr5	112458453	112458453	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggtcttggtccatgcttcGagagtcctcgttgacctcgt	4	14	11	12	3	1	2	0	1	1	1	6	3	3	2	3	2	1	2	3	2	0	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:112458453G>A	uc003kqj.3	-	4	915	c.385C>T	c.(385-387)CGA>TGA	p.R129*	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Nonsense_Mutation_p.R319*|MCC_uc011cwb.1_Nonsense_Mutation_p.R129*|MCC_uc010jcd.1_Nonsense_Mutation_p.R91*	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	129					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		TCCATGCTTCGAGAGTCCTCG	0.522													6	60					0	0	0	0	A	112458453	A	A	112458453	4	1	61	1	0	0	0	0	0	1	0	0	9426	1066	37	1	2160	1	MCC	5	112458453	Nonsense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	284503	112458453	68456807	62	12388											
SLC12A2	6558	broad.mit.edu	37	chr5	127420048	127420048	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccggctaaaggcagcgaggaAgccaagggccgcttccgcgt	9	4	15	13	5	0	0	0	0	0	0	1	2	1	1	4	4	2	3	4	4	4	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:127420048A>T	uc003kus.2	+	1	566	c.402A>T	c.(400-402)GAA>GAT	p.E134D	FLJ33630_uc003kun.2_5'Flank|FLJ33630_uc003kuo.2_5'Flank|FLJ33630_uc003kup.1_5'Flank|FLJ33630_uc003kuq.1_5'Flank|FLJ33630_uc003kur.2_5'Flank|SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Missense_Mutation_p.E134D	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	134	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCAGCGAGGAAGCCAAGGGCC	0.637													3	9					0	0	0	0	T	127420048	T	T	127420048	3	4	61	1	0	0	0	0	1	0	0	0	14448	69	3	5	404	5	SLC12A2	5	127420048	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	14961595	127420048	53495212	63	12389											
NEUROG1	4762	broad.mit.edu	37	chr5	134870804	134870804	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtcagagagcggggaggCggcggcggcacctgagcccc	6	2	21	12	4	1	2	1	1	0	1	1	4	1	3	3	8	2	1	3	8	0	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:134870804C>T	uc003lax.2	-	1	836	c.577G>A	c.(577-579)GCC>ACC	p.A193T		NM_006161	NP_006152	Q92886	NGN1_HUMAN	neurogenin 1	193					positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	nucleus	chromatin binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGCGGGGAGGCGGCGGCGGCA	0.721													14	32					0	0	0	0	T	134870804	T	T	134870804	3	4	61	1	0	0	0	0	1	0	0	0	10406	768	27	1	140	1	NEUROG1	5	134870804	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	7450756	134870804	46044456	64	12390											
PCDHA1	56147	broad.mit.edu	37	chr5	140167198	140167198	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgggccacggccagggtGtccgtggaggtggccgacgt	4	7	19	11	4	0	0	0	0	0	0	1	2	1	1	4	6	0	0	4	6	0	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:140167198G>T	uc003lhb.2	+	1	1323	c.1323G>T	c.(1321-1323)GTG>GTT	p.V441V	PCDHA1_uc003lha.2_Silent_p.V441V|PCDHA1_uc003lgz.2_Silent_p.V441V	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	441	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGCCAGGGTGTCCGTGGAGG	0.662													7	124					1.12685e-05	1.20501e-05	1	0	T	140167198	T	T	140167198	2	4	61	1	0	0	0	0	0	0	0	1	11573	1364	48	4		4	PCDHA1	5	140167198	Silent	SNP	G	TCGA-CN-5364-01A-01D-1434-08	5296394	140167198	40748062	65	12391											
HAVCR2	84868	broad.mit.edu	37	chr5	156522408	156522434	+	In_Frame_Del	DEL	AGAGTCCCGTAAGTCATTGGCCAATCT	-	-																															cctattctgatggttgctccAgagtcccgtaagtcattggc																										TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr5:156522408_156522434delAGAGTCCCGTAAGTCATTGGCCAATCT	uc003lwk.1	-	5	703_729	c.559_585delAGATTGGCCAATGACTTACGGGACTCT	c.(559-585)AGATTGGCCAATGACTTACGGGACTCTdel	p.RLANDLRDS187del		NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	187_195	Extracellular (Potential).					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGTTGCTCCAGAGTCCCGTAAGTCATTGGCCAATCTAGAGTCCCGT	0.445													---	---	---								-	156522434	-	-	156522408	7	5	61	1	0	1	0	1	0	0	0	0	7013	175	7	0	332	0	HAVCR2	5	156522408	In_Frame_Del	DEL	AGAGTCCCGTAAGTCATTGGCCAATCT	TCGA-CN-5364-01A-01D-1434-08	16355210	156522408	24392852	66	12392											
TFAP2A	7020	broad.mit.edu	37	chr6	10404781	10404781	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagcgacgcgttgagacactCgggtggtgagagccgccgct	7	6	16	12	6	0	2	0	2	0	2	1	5	0	2	2	2	2	2	2	2	0	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:10404781C>T	uc003myr.2	-	4	976	c.724G>A	c.(724-726)GAG>AAG	p.E242K	TFAP2A_uc003myq.2_Missense_Mutation_p.E236K|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Missense_Mutation_p.E242K|TFAP2A_uc003myt.2_Missense_Mutation_p.E238K|TFAP2A_uc003myu.1_Missense_Mutation_p.E242K	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	242					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				TTGAGACACTCGGGTGGTGAG	0.507													6	11					0	0	0	0	T	10404781	T	T	10404781	3	4	61	1	0	0	0	0	1	0	0	0	15853	893	31	1	605	1	TFAP2A	6	10404781	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08		10404781	160710286	67	12393											
HSPA1L	3305	broad.mit.edu	37	chr6	31778584	31778584	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcagcagcaggtcctgtaccTtctcagacttgtcccccatc	7	10	8	16	0	1	1	1	0	1	1	5	1	3	1	4	1	3	4	4	1	1	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:31778584T>C	uc003nxh.2	-	2	1349	c.1166A>G	c.(1165-1167)AAG>AGG	p.K389R	HSPA1L_uc010jte.2_Missense_Mutation_p.K389R	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	389					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						GTCCTGTACCTTCTCAGACTT	0.587													16	71					0	0	0	0	C	31778584	C	C	31778584	3	2	61	1	0	0	0	0	1	0	0	0	7449	1609	56	5	763	5	HSPA1L	6	31778584	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	21373803	31778584	139336483	68	12394											
EPHA7	2045	broad.mit.edu	37	chr6	94120846	94120846	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggcacacctggtatgttcGtatcggggtatagttctcat	7	15	11	8	2	1	0	1	0	1	0	4	0	1	0	1	4	0	6	1	4	4	7			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:94120846G>A	uc003poe.2	-	3	446	c.205C>T	c.(205-207)CGA>TGA	p.R69*	EPHA7_uc003pof.2_Nonsense_Mutation_p.R69*|EPHA7_uc011eac.1_Nonsense_Mutation_p.R69*|EPHA7_uc003pog.3_Nonsense_Mutation_p.R69*	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	69	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.R69Q(1)		lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGGTATGTTCGTATCGGGGTA	0.393													31	99					0	0	0	0	A	94120846	A	A	94120846	4	1	61	1	0	0	0	0	0	1	0	0	5196	1153	40	1	2851	1	EPHA7	6	94120846	Nonsense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	62342262	94120846	76994221	69	12395											
ROS1	6098	broad.mit.edu	37	chr6	117630083	117630083	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaatctcccaaatcagaattCcaaaagacctaagaatagta	20	8	4	9	0	2	3	1	0	1	3	4	3	3	3	3	0	0	1	3	0	9	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:117630083C>A	uc003pxp.1	-	41	6642	c.6443G>T	c.(6442-6444)GGA>GTA	p.G2148V	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2148	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AATCAGAATTCCAAAAGACCT	0.393			T	GOPC|ROS1	glioblastoma|NSCLC								13	53					6.31663e-08	6.99746e-08	1	0	A	117630083	A	A	117630083	3	1	61	1	0	0	0	0	1	0	0	0	13596	855	30	2	612	2	ROS1	6	117630083	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	23509237	117630083	53484984	70	12396											
SLC2A12	154091	broad.mit.edu	37	chr6	134323170	134323170	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgatatttgttccaaagaGcatccctttgtctcaggtat	10	16	7	8	0	1	2	1	1	1	1	4	2	3	2	2	1	1	3	2	1	3	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:134323170G>T	uc003qem.1	-	4	1836	c.1665C>A	c.(1663-1665)TGC>TGA	p.C555*		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	555	Cytoplasmic (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		GTTCCAAAGAGCATCCCTTTG	0.363													16	67					1.3612e-06	1.49007e-06	1	0	T	134323170	T	T	134323170	4	4	61	1	0	0	0	0	0	1	0	0	14605	963	34	4	196	4	SLC2A12	6	134323170	Nonsense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	16693087	134323170	36791897	71	12397											
HIVEP2	3097	broad.mit.edu	37	chr6	143081528	143081528	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaatagctgatcaacgaaGaatgtcccagggaactatct	15	8	8	10	1	2	2	1	1	1	1	3	4	3	3	2	1	3	1	2	1	7	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr6:143081528G>T	uc003qjd.2	-	9	6640	c.5897C>A	c.(5896-5898)TCT>TAT	p.S1966Y		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1966					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GATCAACGAAGAATGTCCCAG	0.483													35	115					4.3181e-19	5.18733e-19	1	0	T	143081528	T	T	143081528	3	4	61	1	0	0	0	0	1	0	0	0	7226	942	33	2	1451	2	HIVEP2	6	143081528	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	8758358	143081528	28033539	72	12398											
SNX8	29886	broad.mit.edu	37	chr7	2296595	2296595	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gacgtggatgagctgcgtctCctggtgcaggcagtacaggg	7	8	17	9	2	1	1	0	1	1	0	2	3	1	2	1	4	4	4	1	4	1	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:2296595C>G	uc003slw.2	-	10	1241	c.1198G>C	c.(1198-1200)GAG>CAG	p.E400Q		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	400					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		AGCTGCGTCTCCTGGTGCAGG	0.622													4	29					0	0	0	0	G	2296595	G	G	2296595	3	3	61	1	0	0	0	0	1	0	0	0	14972	864	30	2	207	2	SNX8	7	2296595	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08		2296595	156842068	73	12399											
SKAP2	8935	broad.mit.edu	37	chr7	26779555	26779555	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttagaacaaaaggaaggtcTtgtgctgcaattggaggaaa	15	10	12	4	0	1	1	0	0	1	1	1	4	1	4	0	4	3	2	0	4	7	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:26779555T>C	uc003syc.2	-	5	629	c.336A>G	c.(334-336)CAA>CAG	p.Q112Q	SKAP2_uc011jzi.1_5'UTR|SKAP2_uc011jzj.1_Silent_p.Q97Q	NM_003930	NP_003921	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	112					B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			pancreas(1)	1						AAGGAAGGTCTTGTGCTGCAA	0.378													11	45					0	0	0	0	C	26779555	C	C	26779555	2	2	61	1	0	0	0	0	0	0	0	1	14421	1606	56	5		5	SKAP2	7	26779555	Silent	SNP	T	TCGA-CN-5364-01A-01D-1434-08	24482960	26779555	132359108	74	12400											
TBRG4	9238	broad.mit.edu	37	chr7	45148633	45148634	+	Frame_Shift_Ins	INS	-	A	A																															ggtggtccacctgcttctctINSatgtagggagtagatgctcg																										TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:45148633_45148634insA	uc003tmv.2	-	2	329_330	c.203_204insT	c.(202-204)ATAfs	p.I68fs	TBRG4_uc003tmu.2_5'Flank|TBRG4_uc003tmw.2_Frame_Shift_Ins_p.I68fs|TBRG4_uc003tmx.2_Frame_Shift_Ins_p.I68fs|TBRG4_uc011kcd.1_Frame_Shift_Ins_p.I79fs|SNORA5B_uc003tna.3_5'Flank	NM_004749	NP_004740	Q969Z0	TBRG4_HUMAN	cell cycle progression 2 protein isoform 1	68					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity				0						CCTGCTTCTCTATGTAGGGAGT	0.554													---	---	---								A	45148634	A	A	45148633	7	5	61	1	0	1	1	0	0	0	0	0	15715	1512	53	0	1731	0	TBRG4	7	45148633	Frame_Shift_Ins	INS	-	TCGA-CN-5364-01A-01D-1434-08	18369078	45148633	113990030	75	12401											
FIGNL1	63979	broad.mit.edu	37	chr7	50513222	50513222	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttcaatttcttcttcactGaggcaacactgctctttgga	8	16	7	10	0	5	1	2	1	3	0	5	2	5	2	0	2	2	3	0	2	2	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:50513222G>A	uc003tpc.2	-	4	2141	c.1764C>T	c.(1762-1764)CTC>CTT	p.L588L	FIGNL1_uc003tpb.2_Silent_p.L477L|FIGNL1_uc003tpd.2_Silent_p.L588L|FIGNL1_uc003tpe.2_Silent_p.L588L|FIGNL1_uc010kyy.2_Silent_p.L588L	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	588					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				CTTCTTCACTGAGGCAACACT	0.453													15	118					0	0	0	0	A	50513222	A	A	50513222	2	1	61	1	0	0	0	0	0	0	0	1	5924	1277	45	2		2	FIGNL1	7	50513222	Silent	SNP	G	TCGA-CN-5364-01A-01D-1434-08	5364589	50513222	108625441	76	12402											
SEMA3C	10512	broad.mit.edu	37	chr7	80439970	80439970	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgttggggttgaaagagcaGcgtccttttccagattcaca	10	11	11	9	2	1	3	1	1	0	2	3	3	3	3	2	2	2	3	2	2	1	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:80439970G>A	uc003uhj.2	-	6	1057	c.495C>T	c.(493-495)CGC>CGT	p.R165R	SEMA3C_uc011kgw.1_Silent_p.R183R|SEMA3C_uc011kgx.1_Silent_p.R17R	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	165	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						TGAAAGAGCAGCGTCCTTTTC	0.353													21	128					0	0	0	0	A	80439970	A	A	80439970	2	1	61	1	0	0	0	0	0	0	0	1	14091	958	34	4		4	SEMA3C	7	80439970	Silent	SNP	G	TCGA-CN-5364-01A-01D-1434-08	29926748	80439970	78698693	77	12403											
PCLO	27445	broad.mit.edu	37	chr7	82583457	82583457	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacagattctatgatagaaGatgccatatcagataaggaa	17	10	8	6	0	2	5	1	1	1	4	2	6	2	6	1	1	2	0	1	1	7	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:82583457G>T	uc003uhx.2	-	5	7101	c.6812C>A	c.(6811-6813)TCT>TAT	p.S2271Y	PCLO_uc003uhv.2_Missense_Mutation_p.S2271Y|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2202					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TATGATAGAAGATGCCATATC	0.408													25	84					6.36457e-07	7.00861e-07	1	0	T	82583457	T	T	82583457	3	4	61	1	0	0	0	0	1	0	0	0	11637	942	33	2	8717	2	PCLO	7	82583457	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	2143487	82583457	76555206	78	12404											
ASNS	440	broad.mit.edu	37	chr7	97482673	97482673	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataggaagaaaatcgatgatCtagaaatgggactctcagtt	16	10	10	5	1	2	3	1	1	2	2	4	6	2	5	0	2	0	1	0	2	6	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr7:97482673C>T	uc003uot.3	-	11	1770	c.1264G>A	c.(1264-1266)GAT>AAT	p.D422N	ASNS_uc011kin.1_Missense_Mutation_p.D339N|ASNS_uc003uou.3_Missense_Mutation_p.D422N|ASNS_uc003uov.3_Missense_Mutation_p.D422N|ASNS_uc011kio.1_Missense_Mutation_p.D401N|ASNS_uc003uow.3_Missense_Mutation_p.D401N|ASNS_uc003uox.3_Missense_Mutation_p.D339N	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	422	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AATCGATGATCTAGAAATGGG	0.368													26	69					0	0	0	0	T	97482673	T	T	97482673	3	4	61	1	0	0	0	0	1	0	0	0	1050	913	32	2	433	2	ASNS	7	97482673	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	14899216	97482673	61655990	79	12405											
RP1L1	94137	broad.mit.edu	37	chr8	10467546	10467546	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttcaatttcctctaactgCgcctcttcttcttgctgtcc	4	18	4	15	1	6	0	1	0	5	0	8	0	8	0	3	0	3	1	3	0	2	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr8:10467546C>T	uc003wtc.2	-	4	4291	c.4062G>A	c.(4060-4062)GCG>GCA	p.A1354A		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1354					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		cctctaactgcgcctcttctt	0.179													34	90					0	0	0	0	T	10467546	T	T	10467546	2	4	61	1	0	0	0	0	0	0	0	1	13598	755	27	1		1	RP1L1	8	10467546	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08		10467546	135896476	80	12406											
COL14A1	7373	broad.mit.edu	37	chr8	121210093	121210093	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagaatagaatggcacttGaatgcatttagcacaaaaga	17	8	8	8	0	0	4	0	1	0	3	0	4	0	4	1	1	2	3	1	1	7	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr8:121210093G>C	uc003yox.2	+	7	901	c.636G>C	c.(634-636)TTG>TTC	p.L212F	COL14A1_uc003yoy.2_5'UTR|COL14A1_uc010mde.1_Intron	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	212	VWFA 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AATGGCACTTGAATGCATTTA	0.388													15	119					0	0	0	0	C	121210093	C	C	121210093	3	2	61	1	0	0	0	0	1	0	0	0	3686	1281	45	2	658	2	COL14A1	8	121210093	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	110742547	121210093	25153929	81	12407											
COL22A1	169044	broad.mit.edu	37	chr8	139696679	139696679	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcactcaccttggttcctaGgggtccagggagtccaggtg	7	9	14	11	0	1	0	1	0	0	0	4	1	4	1	4	5	1	2	4	5	1	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr8:139696679G>T	uc003yvd.2	-	39	3448	c.3001C>A	c.(3001-3003)CTA>ATA	p.L1001I	COL22A1_uc011ljo.1_Missense_Mutation_p.L301I	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1001	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTGGTTCCTAGGGGTCCAGGG	0.488										HNSCC(7;0.00092)			52	264					6.20943e-19	7.36375e-19	1	0	T	139696679	T	T	139696679	3	4	61	1	0	0	0	0	1	0	0	0	3696	991	35	4	1987	4	COL22A1	8	139696679	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	18486586	139696679	6667343	82	12408											
SMARCA2	6595	broad.mit.edu	37	chr9	2086844	2086844	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatagattcggtggaaatacAtgatagtggacgaaggccac	14	9	12	6	2	0	2	0	1	0	1	1	5	0	4	1	4	1	0	1	4	6	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:2086844A>T	uc003zhc.2	+	18	2641	c.2542A>T	c.(2542-2544)ATG>TTG	p.M848L	SMARCA2_uc003zhd.2_Missense_Mutation_p.M848L|SMARCA2_uc010mha.2_Missense_Mutation_p.M839L	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	848	Helicase ATP-binding.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GTGGAAATACATGATAGTGGA	0.478													26	104					0	0	0	0	T	2086844	T	T	2086844	3	4	61	1	0	0	0	0	1	0	0	0	14833	217	8	5	2608	5	SMARCA2	9	2086844	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08		2086844	139126587	83	12409											
RFX3	5991	broad.mit.edu	37	chr9	3293119	3293119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagccccataaaaattgatCttattaattttccaaaagag	16	13	5	7	0	1	2	0	1	1	1	2	2	2	2	3	0	1	1	3	0	8	7			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:3293119C>T	uc003zhr.2	-	7	1001	c.689G>A	c.(688-690)AGA>AAA	p.R230K	RFX3_uc010mhd.2_Missense_Mutation_p.R230K|RFX3_uc003zhs.1_Missense_Mutation_p.R230K|RFX3_uc003zht.1_Missense_Mutation_p.R230K|RFX3_uc010mhe.1_Missense_Mutation_p.R205K	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	230	RFX-type winged-helix.				cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		AAAAATTGATCTTATTAATTT	0.408													19	91					0	0	0	0	T	3293119	T	T	3293119	3	4	61	1	0	0	0	0	1	0	0	0	13329	913	32	2	1764	2	RFX3	9	3293119	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	1206275	3293119	137920312	84	12410											
KIAA1432	57589	broad.mit.edu	37	chr9	5713936	5713936	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacaccccattttaaggaaGaacagtgtgctccagcatta	13	9	9	10	0	0	1	0	0	0	1	1	3	1	3	3	2	3	2	3	2	4	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:5713936G>C	uc003zji.2	+	3	229	c.136G>C	c.(136-138)GAA>CAA	p.E46Q	KIAA1432_uc003zjh.2_Missense_Mutation_p.E46Q|KIAA1432_uc003zjl.3_Missense_Mutation_p.E46Q|KIAA1432_uc003zjj.1_5'UTR	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	125						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TTTTAAGGAAGAACAGTGTGC	0.393													16	73					0	0	0	0	C	5713936	C	C	5713936	3	2	61	1	0	0	0	0	1	0	0	0	8272	943	33	2	146	2	KIAA1432	9	5713936	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	2420817	5713936	135499495	85	12411											
PTPRD	5789	broad.mit.edu	37	chr9	8633337	8633337	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccgcaaaactgtgagtctgGtggatacacttatttctccc	9	12	8	12	1	2	1	0	1	2	0	3	2	2	2	2	2	2	1	2	2	4	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:8633337G>T	uc003zkk.2	-	13	1043	c.332C>A	c.(331-333)ACC>AAC	p.T111N	PTPRD_uc003zkp.2_Missense_Mutation_p.T111N|PTPRD_uc003zkq.2_Missense_Mutation_p.T111N|PTPRD_uc003zkr.2_Missense_Mutation_p.T111N|PTPRD_uc003zks.2_Missense_Mutation_p.T111N|PTPRD_uc003zkl.2_Missense_Mutation_p.T111N|PTPRD_uc003zkm.2_Missense_Mutation_p.T111N|PTPRD_uc003zkn.2_Missense_Mutation_p.T111N|PTPRD_uc003zko.2_Missense_Mutation_p.T111N|PTPRD_uc003zkt.1_Missense_Mutation_p.T111N	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	111	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGTGAGTCTGGTGGATACACT	0.423										TSP Lung(15;0.13)			34	108					6.97489e-18	8.1668e-18	1	0	T	8633337	T	T	8633337	3	4	61	1	0	0	0	0	1	0	0	0	12864	1261	44	4	5606	4	PTPRD	9	8633337	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	2919401	8633337	132580094	86	12412											
UNC13B	10497	broad.mit.edu	37	chr9	35403770	35403770	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggaaatgaggaggggcccGagtcctatgagttgcagata	11	8	16	6	1	0	3	0	2	0	1	1	6	1	5	2	4	1	2	2	4	3	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:35403770G>A	uc003zwq.2	+	39	4808	c.4516G>A	c.(4516-4518)GAG>AAG	p.E1506K	UNC13B_uc003zwr.2_Missense_Mutation_p.E1525K|ATP8B5P_uc010mkn.1_5'Flank|ATP8B5P_uc010mko.2_5'Flank|ATP8B5P_uc010mkp.2_5'Flank|ATP8B5P_uc003zwu.2_5'Flank	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	1506	C2 3.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GGAGGGGCCCGAGTCCTATGA	0.552													18	54					0	0	0	0	A	35403770	A	A	35403770	3	1	61	1	0	0	0	0	1	0	0	0	17053	1059	37	1	4670	1	UNC13B	9	35403770	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	26770433	35403770	105809661	87	12413											
FRMD3	257019	broad.mit.edu	37	chr9	86153021	86153021	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgtggcaggagatctcCgagtcgtccagcagccggat	8	8	15	10	3	1	1	0	0	1	1	4	5	2	3	3	4	2	2	3	4	0	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:86153021C>A	uc004ams.1	-	1	328	c.126G>T	c.(124-126)TCG>TCT	p.S42S	FRMD3_uc004amr.1_Silent_p.S28S	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	42	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						AGGAGATCTCCGAGTCGTCCA	0.652													6	30					0.00116845	0.00122126	1	0	A	86153021	A	A	86153021	2	1	61	1	0	0	0	0	0	0	0	1	6084	639	23	3		3	FRMD3	9	86153021	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08	50749251	86153021	55060410	88	12414											
ZNF883	169834	broad.mit.edu	37	chr9	115760233	115760233	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctatgactaaaggttttttCacattcattacactcataag	13	15	4	9	0	3	1	3	1	0	0	3	1	3	1	1	1	1	1	1	1	5	8			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:115760233C>A	uc011lwy.1	-	5	1546	c.307G>T	c.(307-309)GAA>TAA	p.E103*		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	103	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGGTTTTTTCACATTCATTA	0.378													13	62					9.31168e-06	1.00155e-05	1	0	A	115760233	A	A	115760233	4	1	61	1	0	0	0	0	0	1	0	0	18265	835	29	2	834	2	ZNF883	9	115760233	Nonsense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	29607212	115760233	25453198	89	12415											
OR1L4	254973	broad.mit.edu	37	chr9	125486771	125486771	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctacttatgtctcgcttgtCtttctgtgcctctcacatca	5	17	6	13	1	5	0	2	0	4	0	7	0	5	0	1	0	2	2	1	0	2	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:125486771C>G	uc004bmu.1	+	1	503	c.503C>G	c.(502-504)TCT>TGT	p.S168C		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTCGCTTGTCTTTCTGTGCC	0.498													20	305					0	0	0	0	G	125486771	G	G	125486771	3	3	61	1	0	0	0	0	1	0	0	0	11019	913	32	2	505	2	OR1L4	9	125486771	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	9726538	125486771	15726660	90	12416											
NUP214	8021	broad.mit.edu	37	chr9	134010311	134010311	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaagaaaagcacccagagatAtttgtgaactttatggagcc	15	9	10	7	0	0	3	0	1	0	2	0	6	0	4	2	1	3	1	2	1	6	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:134010311A>G	uc004cag.2	+	8	969	c.858A>G	c.(856-858)ATA>ATG	p.I286M	NUP214_uc004cah.2_Missense_Mutation_p.I286M|NUP214_uc004caf.1_Missense_Mutation_p.I286M	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	286					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		ACCCAGAGATATTTGTGAACT	0.398			T	DEK|SET|ABL1	AML|T-ALL								13	73					0	0	0	0	G	134010311	G	G	134010311	3	3	61	1	0	0	0	0	1	0	0	0	10816	439	16	5	888	5	NUP214	9	134010311	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	8523540	134010311	7203120	91	12417											
SETX	23064	broad.mit.edu	37	chr9	135140296	135140296	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttcactgcatcatgtctaTagtttttgtcacaggtctta	8	18	6	9	0	6	0	3	0	3	0	6	0	6	0	0	1	1	2	0	1	3	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:135140296T>C	uc004cbk.2	-	26	7547	c.7364A>G	c.(7363-7365)TAT>TGT	p.Y2455C	SETX_uc004cbj.2_Missense_Mutation_p.Y2103C|SETX_uc010mzt.2_Missense_Mutation_p.Y2041C	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2455					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ATCATGTCTATAGTTTTTGTC	0.478													58	117					0	0	0	0	C	135140296	C	C	135140296	3	2	61	1	0	0	0	0	1	0	0	0	14206	1406	49	5	673	5	SETX	9	135140296	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	1129985	135140296	6073135	92	12418											
KIAA0649	9858	broad.mit.edu	37	chr9	138377934	138377934	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctctgacggcgacagtagCtccgtggacagcgatgacag	9	6	14	12	5	1	2	0	2	1	0	2	5	2	3	1	2	2	3	1	2	1	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr9:138377934C>T	uc004cfr.1	+	4	2127	c.1578C>T	c.(1576-1578)AGC>AGT	p.S526S		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	526						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		GCGACAGTAGCTCCGTGGACA	0.627													6	200					0	0	0	0	T	138377934	T	T	138377934	2	4	61	1	0	0	0	0	0	0	0	1	8226	796	28	4		4	KIAA0649	9	138377934	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08	3237638	138377934	2835497	93	12419											
NMT2	9397	broad.mit.edu	37	chr10	15175327	15175327	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggcgtacgttgtctttatCtggttcaattgcaccatgag	7	16	10	8	2	3	1	1	1	2	0	3	1	3	1	1	2	2	4	1	2	3	7			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr10:15175327C>G	uc001inz.1	-	4	511	c.427G>C	c.(427-429)GAT>CAT	p.D143H	NMT2_uc001ioa.1_Missense_Mutation_p.D130H|NMT2_uc009xjo.1_Missense_Mutation_p.D143H|NMT2_uc010qbz.1_5'UTR	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	143					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						TTGTCTTTATCTGGTTCAATT	0.398													24	109					0	0	0	0	G	15175327	G	G	15175327	3	3	61	1	0	0	0	0	1	0	0	0	10558	913	32	2	1105	2	NMT2	10	15175327	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08		15175327	120359420	94	12420											
PCDH15	65217	broad.mit.edu	37	chr10	55591229	55591229	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccggatctccagaatgcGtcctccttccccataatacg	9	10	7	15	3	1	1	0	0	1	1	6	2	5	2	6	1	2	0	6	1	3	3	rs138398244		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr10:55591229G>A	uc001jju.1	-	30	4443	c.4048C>T	c.(4048-4050)CGC>TGC	p.R1350C	PCDH15_uc010qhq.1_Missense_Mutation_p.R1355C|PCDH15_uc010qhr.1_Missense_Mutation_p.R1350C|PCDH15_uc010qhs.1_Missense_Mutation_p.R1362C|PCDH15_uc010qht.1_Missense_Mutation_p.R1357C|PCDH15_uc010qhu.1_Missense_Mutation_p.R1350C|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.R1350C|PCDH15_uc010qhw.1_Missense_Mutation_p.R1313C|PCDH15_uc010qhx.1_Missense_Mutation_p.R1279C|PCDH15_uc010qhy.1_Missense_Mutation_p.R1355C|PCDH15_uc010qhz.1_Missense_Mutation_p.R1350C|PCDH15_uc010qia.1_Missense_Mutation_p.R1328C|PCDH15_uc010qib.1_Missense_Mutation_p.R1328C	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1350	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCCAGAATGCGTCCTCCTTCC	0.413										HNSCC(58;0.16)			22	92					0	0	0	0	A	55591229	A	A	55591229	3	1	61	1	0	0	0	0	1	0	0	0	11565	1145	40	1	3454	1	PCDH15	10	55591229	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	40415902	55591229	79943518	95	12421											
TNKS2	80351	broad.mit.edu	37	chr10	93586790	93586790	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccagcatggtgcctgtgtaaAtgcaatggacttgtggcaat	10	11	12	8	0	0	0	0	0	0	0	0	1	0	1	2	3	3	4	2	3	4	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr10:93586790A>G	uc001khp.2	+	8	1109	c.812A>G	c.(811-813)AAT>AGT	p.N271S		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	271	ANK 5.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				GCCTGTGTAAATGCAATGGAC	0.368													15	81					0	0	0	0	G	93586790	G	G	93586790	3	3	61	1	0	0	0	0	1	0	0	0	16387	101	4	5	842	5	TNKS2	10	93586790	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	37995561	93586790	41947957	96	12422											
RNH1	6050	broad.mit.edu	37	chr11	494726	494726	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagggatggcttgtccttctCcagggcctgcagccggtcct	4	10	13	14	1	1	0	0	0	1	0	4	1	3	1	5	4	2	2	5	4	0	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:494726C>G	uc001lpk.1	-	9	2759	c.1351G>C	c.(1351-1353)GAG>CAG	p.E451Q	RNH1_uc001lpl.1_Missense_Mutation_p.E451Q|RNH1_uc001lpm.1_Missense_Mutation_p.E451Q|RNH1_uc001lpn.1_Missense_Mutation_p.E451Q|RNH1_uc001lpo.1_Missense_Mutation_p.E451Q|RNH1_uc009ybw.1_RNA|RNH1_uc001lpp.1_Missense_Mutation_p.E451Q|RNH1_uc001lpt.1_Missense_Mutation_p.E208Q|RNH1_uc001lpq.1_Missense_Mutation_p.E451Q|RNH1_uc001lpr.1_Missense_Mutation_p.E451Q|RNH1_uc001lps.1_Missense_Mutation_p.E451Q	NM_203389	NP_976323	P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor	451					mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity				0		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTGTCCTTCTCCAGGGCCTGC	0.657													21	131					0	0	0	0	G	494726	G	G	494726	3	3	61	1	0	0	0	0	1	0	0	0	13569	864	30	2	38	2	RNH1	11	494726	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08		494726	134511790	97	12423											
KCNA4	3739	broad.mit.edu	37	chr11	30032400	30032400	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttccatctctagatactctGacttgtcccccagggaagaa	10	11	7	13	0	2	3	0	1	2	2	5	4	4	4	3	1	1	0	3	1	4	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:30032400G>A	uc001msk.2	-	2	2978	c.1826C>T	c.(1825-1827)TCA>TTA	p.S609L		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	609						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TAGATACTCTGACTTGTCCCC	0.463													18	82					0	0	0	0	A	30032400	A	A	30032400	3	1	61	1	0	0	0	0	1	0	0	0	8044	1294	45	2	139	2	KCNA4	11	30032400	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	29537674	30032400	104974116	98	12424											
KBTBD4	55709	broad.mit.edu	37	chr11	47594881	47594881	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaagtccagatcattctcCtccccccctagtaagtagat	12	10	6	13	0	2	3	1	0	1	3	5	3	4	3	5	0	0	2	5	0	5	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:47594881C>T	uc001nfx.2	-	4	1329	c.1158G>A	c.(1156-1158)GAG>GAA	p.E386E	PTPMT1_uc001nfs.3_3'UTR|PTPMT1_uc001nfv.3_3'UTR|PTPMT1_uc009ylt.2_3'UTR|PTPMT1_uc001nfu.3_3'UTR|NDUFS3_uc001nft.3_Intron|KBTBD4_uc001nfw.1_Silent_p.E411E|KBTBD4_uc001nfz.2_Silent_p.E402E|KBTBD4_uc001nfy.2_Silent_p.E386E	NM_016506	NP_057590	Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	386	Kelch 4.									ovary(1)|central_nervous_system(1)	2						GATCATTCTCCTCCCCCCCTA	0.512													27	94					0	0	0	0	T	47594881	T	T	47594881	2	4	61	1	0	0	0	0	0	0	0	1	8034	680	24	4		4	KBTBD4	11	47594881	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08	17562481	47594881	87411635	99	12425											
OR5L1	219437	broad.mit.edu	37	chr11	55579185	55579185	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcaataattgtgccaaaaatGttggctaatatctttaacaa	16	14	5	6	0	2	0	1	0	1	0	2	0	2	0	1	1	2	2	1	1	8	7			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:55579185G>T	uc001nhw.1	+	1	243	c.243G>T	c.(241-243)ATG>ATT	p.M81I		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TGCCAAAAATGTTGGCTAATA	0.458													64	246					1.69475e-38	2.07635e-38	1	0	T	55579185	T	T	55579185	3	4	61	1	0	0	0	0	1	0	0	0	11224	1377	48	4	245	4	OR5L1	11	55579185	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	7984304	55579185	79427331	100	12426											
OR8J1	219477	broad.mit.edu	37	chr11	56127847	56127847	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgggctgaccatggcagggaAcctgggcatcatcaccctca	9	7	12	13	0	3	1	3	1	0	0	3	2	3	2	3	4	1	3	3	4	1	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:56127847A>T	uc010rjh.1	+	1	125	c.125A>T	c.(124-126)AAC>ATC	p.N42I		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATGGCAGGGAACCTGGGCATC	0.493													34	132					0	0	0	0	T	56127847	T	T	56127847	3	4	61	1	0	0	0	0	1	0	0	0	11295	43	2	5	127	5	OR8J1	11	56127847	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	548662	56127847	78878669	101	12427											
RARRES3	5920	broad.mit.edu	37	chr11	63312266	63312266	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgatcatcagttctgcgaagGagatggttggtcagaagatg	11	11	14	5	1	4	4	3	1	1	3	4	6	4	4	0	3	1	2	0	3	2	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:63312266G>A	uc001nxf.3	+	3	360	c.292G>A	c.(292-294)GAG>AAG	p.E98K		NM_004585	NP_004576	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene	98					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			ovary(1)	1						TTCTGCGAAGGAGATGGTTGG	0.517													51	144					0	0	0	0	A	63312266	A	A	63312266	3	1	61	1	0	0	0	0	1	0	0	0	13122	1175	41	2	302	2	RARRES3	11	63312266	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	7184419	63312266	71694250	102	12428											
FERMT3	83706	broad.mit.edu	37	chr11	63990913	63990913	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagcgggcccgtggggaggaGctggatgaagacctcttcct	7	7	17	10	2	1	2	0	1	1	1	2	6	2	5	3	5	2	1	3	5	1	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:63990913G>A	uc001nyl.2	+	15	2102	c.1953G>A	c.(1951-1953)GAG>GAA	p.E651E	FERMT3_uc001nym.2_Silent_p.E647E|NUDT22_uc009ypd.2_5'Flank|NUDT22_uc001nyp.3_5'Flank|NUDT22_uc009ype.2_5'Flank|NUDT22_uc001nyq.3_5'Flank	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	651					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						GTGGGGAGGAGCTGGATGAAG	0.622													16	43					0	0	0	0	A	63990913	A	A	63990913	2	1	61	1	0	0	0	0	0	0	0	1	5851	962	34	4		4	FERMT3	11	63990913	Silent	SNP	G	TCGA-CN-5364-01A-01D-1434-08	678647	63990913	71015603	103	12429											
SLC22A12	116085	broad.mit.edu	37	chr11	64366325	64366325	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agctgagcatgggccagcctCctgccagcctgggcaccctg	6	6	13	16	0	0	1	0	1	0	0	1	1	1	1	6	2	5	3	6	2	0	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:64366325C>T	uc001oam.1	+	6	1747	c.1000C>T	c.(1000-1002)CCT>TCT	p.P334S	SLC22A12_uc009ypr.1_Missense_Mutation_p.P359S|SLC22A12_uc001oal.1_Missense_Mutation_p.P113S|SLC22A12_uc009yps.1_Missense_Mutation_p.P300S|SLC22A12_uc001oan.1_Missense_Mutation_p.P226S|SLC22A12_uc009ypt.2_Missense_Mutation_p.P152S	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	334					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						GGGCCAGCCTCCTGCCAGCCT	0.672													4	71					0	0	0	0	T	64366325	T	T	64366325	3	4	61	1	0	0	0	0	1	0	0	0	14508	855	30	2	1022	2	SLC22A12	11	64366325	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	375412	64366325	70640191	104	12430											
NAALADL1	10004	broad.mit.edu	37	chr11	64813578	64813578	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaacttctccactgcagtcaCcagaggccctgtgaggaaca	12	7	9	13	0	2	2	1	1	1	1	3	3	2	3	3	2	3	1	3	2	2	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:64813578C>A	uc001ocn.2	-	16	1880	c.1864G>T	c.(1864-1866)GTG>TTG	p.V622L	NAALADL1_uc010rnw.1_Missense_Mutation_p.V98L|NAALADL1_uc009ypz.2_RNA	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	622	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						ACTGCAGTCACCAGAGGCCCT	0.607													20	76					7.45023e-12	8.50797e-12	1	0	A	64813578	A	A	64813578	3	1	61	1	0	0	0	0	1	0	0	0	10182	507	18	4	370	4	NAALADL1	11	64813578	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	447253	64813578	70192938	105	12431											
MUS81	80198	broad.mit.edu	37	chr11	65631171	65631171	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	attttgtgtgggtggcccagGagaccaatcctagagaccca	10	9	12	10	0	0	2	0	0	0	2	1	4	1	2	4	3	0	0	4	3	2	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:65631171G>C	uc001ofv.3	+	9	1293	c.940G>C	c.(940-942)GAG>CAG	p.E314Q	MUS81_uc001ofw.3_RNA|MUS81_uc001ofx.3_5'UTR	NM_025128	NP_079404	Q96NY9	MUS81_HUMAN	MUS81 endonuclease homolog	314	ERCC4.				DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding				0				READ - Rectum adenocarcinoma(159;0.166)		GGTGGCCCAGGAGACCAATCC	0.657								Homologous_recombination					10	109					0	0	0	0	C	65631171	C	C	65631171	3	2	61	1	0	0	0	0	1	0	0	0	10041	1175	41	2	974	2	MUS81	11	65631171	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	817593	65631171	69375345	106	12432											
NPAS4	266743	broad.mit.edu	37	chr11	66192180	66192180	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgtccccctggtgcccGaaggcctgctcacacctgag	6	8	12	15	1	1	1	1	1	0	0	2	3	2	2	5	3	2	1	5	3	1	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:66192180G>T	uc001ohx.1	+	7	1995	c.1819G>T	c.(1819-1821)GAA>TAA	p.E607*	NPAS4_uc010rpc.1_Nonsense_Mutation_p.E397*	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	607					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CCTGGTGCCCGAAGGCCTGCT	0.592													20	349					2.37509e-13	2.7462e-13	1	0	T	66192180	T	T	66192180	4	4	61	1	0	0	0	0	0	1	0	0	10619	1059	37	3	1845	3	NPAS4	11	66192180	Nonsense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	561009	66192180	68814336	107	12433											
ATM	472	broad.mit.edu	37	chr11	108224518	108224518	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcttttgaacagggcaaaatCcttcctactcctgagacagt	11	11	8	11	0	0	2	0	2	0	1	3	3	3	2	3	1	2	2	3	1	4	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr11:108224518C>G	uc001pkb.1	+	60	9082	c.8697C>G	c.(8695-8697)ATC>ATG	p.I2899M	ATM_uc009yxr.1_Missense_Mutation_p.I2899M|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.I1551M	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2899	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGGGCAAAATCCTTCCTACTC	0.398			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			85	115					0	0	0	0	G	108224518	G	G	108224518	3	3	61	1	0	0	0	0	1	0	0	0	1111	845	30	2	8931	2	ATM	11	108224518	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	42032338	108224518	26781998	108	12434											
CPNE8	144402	broad.mit.edu	37	chr12	39223185	39223185	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attaaaaaatacttacactaTtggtttttccaggcgacttc	13	15	5	8	1	0	0	0	0	0	0	2	1	1	0	1	2	2	1	1	2	6	8			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr12:39223185T>A	uc001rls.1	-	6	487	c.403A>T	c.(403-405)ATA>TTA	p.I135L		NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	135										pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				ACTTACACTATTGGTTTTTCC	0.363													46	213					0	0	0	0	A	39223185	A	A	39223185	3	1	61	1	0	0	0	0	1	0	0	0	3833	1493	52	5	1351	5	CPNE8	12	39223185	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08		39223185	94628710	109	12435											
XPOT	11260	broad.mit.edu	37	chr12	64818445	64818445	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactgttggacaggcttgctCaagtttcaccagagttacta	10	13	9	9	0	2	1	2	0	0	1	2	2	2	2	1	2	3	5	1	2	4	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr12:64818445C>G	uc001ssb.2	+	12	1675	c.1249C>G	c.(1249-1251)CAA>GAA	p.Q417E		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	417					intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		CAGGCTTGCTCAAGTTTCACC	0.373													20	116					0	0	0	0	G	64818445	G	G	64818445	3	3	61	1	0	0	0	0	1	0	0	0	17518	827	29	2	1291	2	XPOT	12	64818445	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	25595260	64818445	69033450	110	12436											
CHPT1	56994	broad.mit.edu	37	chr12	102091698	102091698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgagggcgctgagcgagcCgctgagcgcggcgcagctgc	5	4	19	13	6	0	3	0	3	0	0	0	4	0	3	1	2	5	5	1	2	0	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr12:102091698C>T	uc001tin.2	+	1	282	c.59C>T	c.(58-60)CCG>CTG	p.P20L	CHPT1_uc001tio.2_RNA|CHPT1_uc001tip.1_Missense_Mutation_p.P20L	NM_020244	NP_064629	Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	20					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding				0						CTGAGCGAGCCGCTGAGCGCG	0.796													3	6					0	0	0	0	T	102091698	T	T	102091698	3	4	61	1	0	0	0	0	1	0	0	0	3385	652	23	1	61	1	CHPT1	12	102091698	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	37273253	102091698	31760197	111	12437											
GNPTAB	79158	broad.mit.edu	37	chr12	102158435	102158435	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcatttgtttcatctgttaTtatagcttgattttttattt	7	25	5	4	0	3	1	2	1	1	0	3	1	3	1	0	0	1	3	0	0	4	10			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr12:102158435T>C	uc001tit.2	-	13	2439	c.2260A>G	c.(2260-2262)ATA>GTA	p.I754V		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	754					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						TCATCTGTTATTATAGCTTGA	0.383													19	69					0	0	0	0	C	102158435	C	C	102158435	3	2	61	1	0	0	0	0	1	0	0	0	6582	1493	52	5	1546	5	GNPTAB	12	102158435	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	66737	102158435	31693460	112	12438											
ZCCHC8	55596	broad.mit.edu	37	chr12	122966496	122966496	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaatgccattagtacctaaTaactcctggcttgaatcttc	13	13	5	10	0	1	1	0	1	1	0	3	1	2	1	3	1	3	2	3	1	7	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr12:122966496T>C	uc001ucn.2	-	9	1002	c.871A>G	c.(871-873)ATT>GTT	p.I291V	ZCCHC8_uc001ucm.2_Missense_Mutation_p.I53V|ZCCHC8_uc009zxp.2_Missense_Mutation_p.I53V|ZCCHC8_uc009zxq.2_Missense_Mutation_p.I53V	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	291						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		TAGTACCTAATAACTCCTGGC	0.383													8	26					0	0	0	0	C	122966496	C	C	122966496	3	2	61	1	0	0	0	0	1	0	0	0	17661	1406	49	5	1276	5	ZCCHC8	12	122966496	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	20808061	122966496	10885399	113	12439											
CENPJ	55835	broad.mit.edu	37	chr13	25458151	25458151	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgctttcttcttgtccAtcaggaaataagtttttaac	13	16	5	7	0	3	0	1	0	2	0	4	1	4	1	1	1	2	2	1	1	5	7			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr13:25458151A>C	uc001upt.3	-	16	4027	c.3774T>G	c.(3772-3774)GAT>GAG	p.D1258E	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	1258					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		CTTCTTGTCCATCAGGAAATA	0.358													27	94					0	0	0	0	C	25458151	C	C	25458151	3	2	61	1	0	0	0	0	1	0	0	0	3249	214	8	5	250	5	CENPJ	13	25458151	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08		25458151	89711727	114	12440											
PIBF1	10464	broad.mit.edu	37	chr13	73366606	73366606	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgaagaattggaggagaaaCttaatgatgcacttcaccag	15	10	10	6	0	1	4	1	2	0	2	1	6	1	5	1	2	2	1	1	2	4	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr13:73366606C>G	uc001vjc.2	+	3	579	c.274C>G	c.(274-276)CTT>GTT	p.L92V	PIBF1_uc001vja.1_Missense_Mutation_p.L92V|PIBF1_uc010aeo.1_RNA|PIBF1_uc001vjb.2_Missense_Mutation_p.L92V|PIBF1_uc010aep.2_Intron	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	92						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		GGAGGAGAAACTTAATGATGC	0.284													9	67					0	0	0	0	G	73366606	G	G	73366606	3	3	61	1	0	0	0	0	1	0	0	0	11934	565	20	4	280	4	PIBF1	13	73366606	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	47908455	73366606	41803272	115	12441											
DOCK9	23348	broad.mit.edu	37	chr13	99476724	99476724	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgtcgatgtttggggtaatGaccctgaaggcggtgcatcc	7	11	14	9	3	0	2	0	2	0	0	3	3	1	2	2	4	1	3	2	4	2	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr13:99476724G>C	uc001vnt.2	-	46	5116	c.5061C>G	c.(5059-5061)GTC>GTG	p.V1687V	DOCK9_uc001vnw.2_Silent_p.V1686V|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.V1664V|DOCK9_uc001vnq.2_Silent_p.V236V|DOCK9_uc001vnr.2_Silent_p.V330V|DOCK9_uc010tin.1_Silent_p.V307V|DOCK9_uc001vns.2_Silent_p.V236V|DOCK9_uc010tio.1_Silent_p.V356V|DOCK9_uc010tip.1_Silent_p.V397V|DOCK9_uc001vnu.1_Silent_p.V236V|DOCK9_uc010tiq.1_Silent_p.V642V	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1687	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTGGGGTAATGACCCTGAAGG	0.537													33	138					0	0	0	0	C	99476724	C	C	99476724	2	2	61	1	0	0	0	0	0	0	0	1	4716	1277	45	2		2	DOCK9	13	99476724	Silent	SNP	G	TCGA-CN-5364-01A-01D-1434-08	26110118	99476724	15693154	116	12442											
MDGA2	161357	broad.mit.edu	37	chr14	47504386	47504386	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcattgcaacttctttatcCgctctagaccaaaggatgat	11	12	8	10	1	2	2	0	1	2	1	3	3	3	3	2	2	2	3	2	2	4	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr14:47504386C>A	uc001wwj.3	-	8	1636	c.1440G>T	c.(1438-1440)GCG>GCT	p.A480A	MDGA2_uc001wwi.3_Silent_p.A251A|MDGA2_uc010ani.2_Silent_p.A40A	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	480	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CTTCTTTATCCGCTCTAGACC	0.413													55	230					6.20943e-19	7.36375e-19	1	0	A	47504386	A	A	47504386	2	1	61	1	0	0	0	0	0	0	0	1	9460	639	23	3		3	MDGA2	14	47504386	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08		47504386	59845154	117	12443											
DLST	1743	broad.mit.edu	37	chr14	75367830	75367830	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taccttcaccattagcaatgGaggcgtttttggctcgctct	7	14	9	11	2	2	0	1	0	1	0	3	1	2	1	2	3	2	4	2	3	3	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr14:75367830G>A	uc001xqv.2	+	14	1184	c.1121G>A	c.(1120-1122)GGA>GAA	p.G374E	DLST_uc001xqu.2_Missense_Mutation_p.G286E|DLST_uc001xqt.2_Missense_Mutation_p.G290E|DLST_uc010tuw.1_Missense_Mutation_p.G288E	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	374					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		ATTAGCAATGGAGGCGTTTTT	0.473													21	94					0	0	0	0	A	75367830	A	A	75367830	3	1	61	1	0	0	0	0	1	0	0	0	4591	1174	41	2	1175	2	DLST	14	75367830	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	27863444	75367830	31981710	118	12444											
DICER1	23405	broad.mit.edu	37	chr14	95560403	95560403	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaggtctgtcaggacccccGgggagtgctgccgcgggtct	4	7	17	13	3	3	0	1	0	2	0	3	2	3	2	3	5	2	2	3	5	0	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr14:95560403G>T	uc001ydw.2	-	25	5368	c.5186C>A	c.(5185-5187)CCG>CAG	p.P1729Q	DICER1_uc010avh.1_Missense_Mutation_p.P627Q|DICER1_uc001ydv.2_Missense_Mutation_p.P1719Q|DICER1_uc001ydx.2_Missense_Mutation_p.P1729Q	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1729	RNase III 2.			P->E: No effect on activity.	negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CAGGACCCCCGGGGAGTGCTG	0.522			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				6	99					2.0095e-06	2.18681e-06	1	0	T	95560403	T	T	95560403	3	4	61	1	0	0	0	0	1	0	0	0	4543	1116	39	3	598	3	DICER1	14	95560403	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	20192573	95560403	11789137	119	12445											
DEGS2	123099	broad.mit.edu	37	chr14	100615443	100615443	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacatgtagtgctcggccacGaagtggcccgagatggggtg	9	7	16	9	3	0	1	0	0	0	1	1	3	0	1	2	4	2	2	2	4	3	1	rs145891510		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr14:100615443G>A	uc001ygx.2	-	2	775	c.687C>T	c.(685-687)TTC>TTT	p.F229F		NM_206918	NP_996801	Q6QHC5	DEGS2_HUMAN	degenerative spermatocyte homolog 2, lipid	229	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity				0		Melanoma(154;0.212)				GCTCGGCCACGAAGTGGCCCG	0.622													10	129					0	0	0	0	A	100615443	A	A	100615443	2	1	61	1	0	0	0	0	0	0	0	1	4445	1049	37	1		1	DEGS2	14	100615443	Silent	SNP	G	TCGA-CN-5364-01A-01D-1434-08	5055040	100615443	6734097	120	12446											
RTF1	23168	broad.mit.edu	37	chr15	41769676	41769676	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttacatcaaccagcggaaccGggagtggaacattgtagagt	13	8	12	8	2	1	1	1	0	0	1	1	4	1	4	2	3	5	1	2	3	5	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr15:41769676G>A	uc001zny.2	+	14	1715	c.1703G>A	c.(1702-1704)CGG>CAG	p.R568Q		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	568					histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		CAGCGGAACCGGGAGTGGAAC	0.433													13	111					0	0	0	0	A	41769676	A	A	41769676	3	1	61	1	0	0	0	0	1	0	0	0	13786	1116	39	1	1757	1	RTF1	15	41769676	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08		41769676	60761716	121	12447											
PARP16	54956	broad.mit.edu	37	chr15	65555578	65555578	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gggccgaggaggctgtgctgCcacccatggccatgggggct	5	6	18	12	1	0	0	0	0	0	0	0	2	0	1	4	6	2	3	4	6	0	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr15:65555578C>T	uc002aoo.2	-	4	854	c.600G>A	c.(598-600)TGG>TGA	p.W200*	PARP16_uc002aop.2_Nonsense_Mutation_p.W85*|PARP16_uc002aoq.2_Nonsense_Mutation_p.W200*	NM_017851	NP_060321	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	200	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			lung(2)	2						GGCTGTGCTGCCACCCATGGC	0.582													11	43					0	0	0	0	T	65555578	T	T	65555578	4	4	61	1	0	0	0	0	0	1	0	0	11514	740	26	4	383	4	PARP16	15	65555578	Nonsense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	23785902	65555578	36975814	122	12448											
MPI	4351	broad.mit.edu	37	chr15	75189376	75189376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtggagtgcatggcgtgttCagacaacacagttcgtgctg	8	10	14	9	3	1	1	1	0	0	1	2	2	1	2	0	2	3	4	0	2	1	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr15:75189376C>T	uc002azc.1	+	7	874	c.869C>T	c.(868-870)TCA>TTA	p.S290L	MPI_uc002azd.1_Intron|MPI_uc010ulx.1_Missense_Mutation_p.S240L|MPI_uc002aze.1_Missense_Mutation_p.S229L	NM_002435	NP_002426	P34949	MPI_HUMAN	mannose-6- phosphate isomerase	290					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			ovary(2)	2						ATGGCGTGTTCAGACAACACA	0.537													48	148					0	0	0	0	T	75189376	T	T	75189376	3	4	61	1	0	0	0	0	1	0	0	0	9782	838	29	2	895	2	MPI	15	75189376	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	9633798	75189376	27342016	123	12449											
FAM173A	65990	broad.mit.edu	37	chr16	772479	772479	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggctggggaggccgcctcCtcgcggatacccatccaggc	6	5	14	16	3	0	0	0	0	0	0	3	2	2	2	5	6	1	1	5	6	1	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:772479C>T	uc002cje.2	+	5	747	c.630C>T	c.(628-630)TCC>TCT	p.S210S		NM_023933	NP_076422	Q9BQD7	F173A_HUMAN	hypothetical protein LOC65990	210						integral to membrane				pancreas(1)	1						AGGCCGCCTCCTCGCGGATAC	0.637													13	30					0	0	0	0	T	772479	T	T	772479	2	4	61	1	0	0	0	0	0	0	0	1	5521	668	24	4		4	FAM173A	16	772479	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08		772479	89582274	124	12450											
CHD9	80205	broad.mit.edu	37	chr16	53358697	53358697	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggaggaactgaaccaagtCctctcaatgaaaacagcaca	18	5	8	10	0	1	2	1	2	1	0	3	4	2	4	2	2	4	1	2	2	7	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:53358697C>T	uc002ehb.2	+	38	8748	c.8584C>T	c.(8584-8586)CCT>TCT	p.P2862S	CHD9_uc002egy.2_Missense_Mutation_p.P2846S|CHD9_uc002ehc.2_Missense_Mutation_p.P2847S|CHD9_uc002ehf.2_Missense_Mutation_p.P1960S|CHD9_uc010cbw.2_Missense_Mutation_p.P928S	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2862					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TGAACCAAGTCCTCTCAATGA	0.398													7	20					0	0	0	0	T	53358697	T	T	53358697	3	4	61	1	0	0	0	0	1	0	0	0	3347	855	30	2	8686	2	CHD9	16	53358697	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	52586218	53358697	36996056	125	12451											
FHOD1	29109	broad.mit.edu	37	chr16	67271255	67271256	+	Frame_Shift_Ins	INS	-	GGAGTCC	GGAGTCC																															gcatccgtcacatcgtagaaINSggagtcctggtccgggagcg																										TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:67271255_67271256insGGAGTCC	uc002esl.2	-	9	991_992	c.879_880insGGACTCC	c.(877-882)TCCTTCfs	p.S293fs	FHOD1_uc010ced.2_Frame_Shift_Ins_p.S100fs|FHOD1_uc010vjh.1_5'UTR	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	293_294	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		ACATCGTAGAAGGAGTCCTGGT	0.663													---	---	---								GGAGTCC	67271256	GGAGTCC	GGAGTCC	67271255	7	5	61	1	0	1	1	0	0	0	0	0	5914	72	3	0	2670	0	FHOD1	16	67271255	Frame_Shift_Ins	INS	-	TCGA-CN-5364-01A-01D-1434-08	13912558	67271255	23083498	126	12452											
GFOD2	81577	broad.mit.edu	37	chr16	67709084	67709084	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgttccgctgaagtgcctCacacaggttctggttggtgt	5	14	13	9	1	2	1	1	1	1	0	3	1	3	1	2	3	1	5	2	3	1	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:67709084C>G	uc002eub.2	-	3	1427	c.1132G>C	c.(1132-1134)GAG>CAG	p.E378Q	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Missense_Mutation_p.E273Q	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	378						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		TGAAGTGCCTCACACAGGTTC	0.627													35	182					0	0	0	0	G	67709084	G	G	67709084	3	3	61	1	0	0	0	0	1	0	0	0	6381	835	29	2	29	2	GFOD2	16	67709084	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	437829	67709084	22645669	127	12453											
SLC7A6OS	84138	broad.mit.edu	37	chr16	68344358	68344358	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtactcggactcctggccGctcgaggtggtccccaagga	6	8	14	13	3	0	0	0	0	0	0	4	3	2	2	4	5	1	2	4	5	2	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:68344358G>T	uc002evw.1	-	2	370	c.351C>A	c.(349-351)AGC>AGA	p.S117R	PRMT7_uc002evx.1_5'Flank|PRMT7_uc002evy.1_5'Flank|PRMT7_uc010vlg.1_5'Flank	NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	117					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		ACTCCTGGCCGCTCGAGGTGG	0.672													5	12					0.00116845	0.00122126	1	0	T	68344358	T	T	68344358	3	4	61	1	0	0	0	0	1	0	0	0	14766	1078	38	3	594	3	SLC7A6OS	16	68344358	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	635274	68344358	22010395	128	12454											
ZFPM1	161882	broad.mit.edu	37	chr16	88601319	88601319	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgcaacatcaagttcagcAgcctgtccaccttcatcgcc	9	11	6	15	1	3	0	3	0	0	0	5	0	4	0	4	0	4	3	4	0	2	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr16:88601319A>T	uc002fkv.2	+	10	2986	c.2953A>T	c.(2953-2955)AGC>TGC	p.S985C		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	985	C2HC-type 5.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CAAGTTCAGCAGCCTGTCCAC	0.622													24	68					0	0	0	0	T	88601319	T	T	88601319	3	4	61	1	0	0	0	0	1	0	0	0	17724	188	7	5	2991	5	ZFPM1	16	88601319	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	20256961	88601319	1753434	129	12455											
DPH1	1801	broad.mit.edu	37	chr17	1939319	1939319	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacctacggggcttgctgtGtggatgacttcacagcgagg	7	10	15	9	2	1	2	1	2	0	0	1	4	1	3	1	4	3	2	1	4	1	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:1939319G>T	uc002fts.2	+	4	367	c.349G>T	c.(349-351)GTG>TTG	p.V117L	DPH1_uc002ftr.1_RNA|DPH1_uc002ftt.2_Missense_Mutation_p.V112L|DPH1_uc010cjx.2_Intron|DPH1_uc010vqs.1_Missense_Mutation_p.V127L|DPH1_uc002ftu.2_5'Flank|DPH1_uc002ftv.2_5'Flank	NM_001383	NP_001374	Q9BZG8	DPH1_HUMAN	diptheria toxin resistance protein required for	117					peptidyl-diphthamide biosynthetic process from peptidyl-histidine|translation	cytoplasm|nucleus				pancreas(1)	1						GGCTTGCTGTGTGGATGACTT	0.647													17	47					7.21436e-19	8.501e-19	1	0	T	1939319	T	T	1939319	3	4	61	1	0	0	0	0	1	0	0	0	4741	1377	48	4	363	4	DPH1	17	1939319	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08		1939319	79255891	130	12456											
TP53	7157	broad.mit.edu	37	chr17	7577046	7577046	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgctccctgggggcagctCgtggtgaggctcccctttct	3	11	14	13	1	1	1	0	1	1	0	4	1	3	1	3	4	2	4	3	4	0	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:7577046C>A	uc002gim.2	-	8	1086	c.892G>T	c.(892-894)GAG>TAG	p.E298*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E298*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E166*|TP53_uc010cng.1_Nonsense_Mutation_p.E166*|TP53_uc002gii.1_Nonsense_Mutation_p.E166*|TP53_uc010cnh.1_Nonsense_Mutation_p.E298*|TP53_uc010cni.1_Nonsense_Mutation_p.E298*|TP53_uc002gij.2_Nonsense_Mutation_p.E298*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	298	Interaction with HIPK1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E298*(35)|p.0?(7)|p.E298K(2)|p.?(2)|p.E298V(2)|p.L299fs*2(1)|p.L265_K305del41(1)|p.E298A(1)|p.E298fs*53(1)|p.G293fs*1(1)|p.E298fs*47(1)|p.E298E(1)|p.E298Q(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGGCAGCTCGTGGTGAGGC	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	66					4.16121e-05	4.42428e-05	1	0	A	7577046	A	A	7577046	4	1	61	1	0	0	0	0	0	1	0	0	16448	893	31	3	394	3	TP53	17	7577046	Nonsense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	5637727	7577046	73618164	131	12457											
DBF4B	80174	broad.mit.edu	37	chr17	42828155	42828155	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatctggtcacttccttggCtctgctgcctggggagtggt	3	14	13	11	0	4	0	2	0	2	0	5	1	5	1	2	5	2	2	2	5	0	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:42828155C>G	uc002ihf.2	+	14	1595	c.1382C>G	c.(1381-1383)GCT>GGT	p.A461G	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	461					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				ACTTCCTTGGCTCTGCTGCCT	0.632													26	93					0	0	0	0	G	42828155	G	G	42828155	3	3	61	1	0	0	0	0	1	0	0	0	4266	797	28	4	1481	4	DBF4B	17	42828155	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	35251109	42828155	38367055	132	12458											
USP32	84669	broad.mit.edu	37	chr17	58343387	58343387	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacttctaaaagtgcaaccaCcatgtctctcagttcaaccc	12	10	5	14	0	4	0	2	0	2	0	5	1	4	0	3	0	3	2	3	0	4	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:58343387C>T	uc002iyo.1	-	8	1163	c.877G>A	c.(877-879)GTG>ATG	p.V293M	USP32_uc010wov.1_Missense_Mutation_p.V293M	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	293	EF-hand 3.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AGTGCAACCACCATGTCTCTC	0.393													7	135					0	0	0	0	T	58343387	T	T	58343387	3	4	61	1	0	0	0	0	1	0	0	0	17131	507	18	4	4045	4	USP32	17	58343387	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	15515232	58343387	22851823	133	12459											
ARSG	22901	broad.mit.edu	37	chr17	66391318	66391318	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgaggtgctctttggccggtCacagcctgggcacagggtaa	7	8	15	11	2	2	0	1	0	1	0	2	1	2	0	2	5	2	3	2	5	1	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:66391318C>T	uc002jhc.2	+	10	1992	c.1196C>T	c.(1195-1197)TCA>TTA	p.S399L	ARSG_uc002jhb.1_Missense_Mutation_p.S235L	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	399					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTTGGCCGGTCACAGCCTGGG	0.582													5	89					0	0	0	0	T	66391318	T	T	66391318	3	4	61	1	0	0	0	0	1	0	0	0	994	838	29	2	1230	2	ARSG	17	66391318	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	8047931	66391318	14803892	134	12460											
SLC9A3R1	9368	broad.mit.edu	37	chr17	72764743	72764743	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagaaacgcagcagcaaacGggccccgcagatggactgga	13	2	13	13	3	0	2	0	0	0	2	0	4	0	4	3	3	4	4	3	3	2	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr17:72764743G>A	uc002jlo.2	+	6	1248	c.1025G>A	c.(1024-1026)CGG>CAG	p.R342Q	SLC9A3R1_uc002jlp.2_Missense_Mutation_p.R186Q	NM_004252	NP_004243	O14745	NHRF1_HUMAN	sodium/hydrogen exchanger regulatory factor 1	342					apoptosis|bile acid secretion|glutathione transport|microvillus assembly|negative regulation of cell proliferation|negative regulation of ERK1 and ERK2 cascade|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|protein complex assembly|regulation of protein kinase activity|regulation of sodium:hydrogen antiporter activity|renal absorption|Wnt receptor signaling pathway	actin cytoskeleton|apical plasma membrane|centrosome|endomembrane system|filopodium|intracellular membrane-bounded organelle|microvillus membrane|ruffle	beta-2 adrenergic receptor binding|beta-catenin binding|chloride channel regulator activity|growth factor receptor binding|PDZ domain binding|phosphatase binding|protein self-association				0						AGCAGCAAACGGGCCCCGCAG	0.612													38	119					0	0	0	0	A	72764743	A	A	72764743	3	1	61	1	0	0	0	0	1	0	0	0	14778	1116	39	1	1047	1	SLC9A3R1	17	72764743	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	6373425	72764743	8430467	135	12461											
OSBPL1A	114876	broad.mit.edu	37	chr18	21745031	21745031	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgactcaggcacgcacctCgtcttccagtcctcttctga	6	11	7	17	2	4	2	1	2	3	0	7	2	6	2	4	1	0	2	4	1	0	2	rs143353189		TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr18:21745031C>T	uc002kve.2	-	27	2922	c.2748G>A	c.(2746-2748)ACG>ACA	p.T916T	OSBPL1A_uc002kvd.2_Silent_p.T403T|OSBPL1A_uc010xbc.1_Silent_p.T534T	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	916					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					GCACGCACCTCGTCTTCCAGT	0.532													69	262					0	0	0	0	T	21745031	T	T	21745031	2	4	61	1	0	0	0	0	0	0	0	1	11331	871	31	1		1	OSBPL1A	18	21745031	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08		21745031	56332217	136	12462											
SMAD4	4089	broad.mit.edu	37	chr18	48591919	48591919	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggacccttctggaggagatcGcttttgtttgggtcaactct	6	14	12	9	1	3	1	1	0	2	1	4	4	3	3	1	4	1	2	1	4	1	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr18:48591919G>A	uc010xdp.1	+	9	1620	c.1082G>A	c.(1081-1083)CGC>CAC	p.R361H	SMAD4_uc002lfb.3_Missense_Mutation_p.R206H	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	361	MH2.		R -> H (in a colorectal cancer sample; somatic mutation).|R -> C (in JPS).		BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.R361C(6)|p.R361H(3)|p.?(2)|p.R361S(1)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GGAGGAGATCGCTTTTGTTTG	0.413									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				16	63					0	0	0	0	A	48591919	A	A	48591919	3	1	61	1	0	0	0	0	1	0	0	0	14824	1087	38	1	1112	1	SMAD4	18	48591919	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	26846888	48591919	29485329	137	12463											
ACSBG2	81616	broad.mit.edu	37	chr19	6185605	6185605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatgaaggctggctacactCtggggatctgggccagctgg	7	9	16	9	0	2	2	0	2	2	0	2	3	2	3	1	6	2	3	1	6	2	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:6185605C>T	uc002mef.1	+	11	1708	c.1481C>T	c.(1480-1482)TCT>TTT	p.S494F	ACSBG2_uc002mee.1_Missense_Mutation_p.S307F|ACSBG2_uc002meg.1_Missense_Mutation_p.S494F|ACSBG2_uc002meh.1_Missense_Mutation_p.S494F|ACSBG2_uc002mei.1_Missense_Mutation_p.S444F|ACSBG2_uc010xiz.1_Missense_Mutation_p.S494F	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	494					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						TGGCTACACTCTGGGGATCTG	0.552													9	151					0	0	0	0	T	6185605	T	T	6185605	3	4	61	1	0	0	0	0	1	0	0	0	174	913	32	2	1519	2	ACSBG2	19	6185605	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08		6185605	52943378	138	12464											
ARHGEF18	23370	broad.mit.edu	37	chr19	7535174	7535176	+	In_Frame_Del	DEL	TCT	-	-																															cgccagcaaagaagacgtcaTcttcttctaaaagggccgtg																										TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:7535174_7535176delTCT	uc002mgi.2	+	19	3765_3767	c.3512_3514delTCT	c.(3511-3516)ATCTTC>ATC	p.F1173del	ARHGEF18_uc010xjm.1_In_Frame_Del_p.F1015del|ARHGEF18_uc002mgh.2_In_Frame_Del_p.F1015del|ARHGEF18_uc002mgj.1_In_Frame_Del_p.F810del	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	1173					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				GAAGACGTCATCTTCTTCTAAAA	0.675													---	---	---								-	7535176	-	-	7535174	7	5	61	1	0	1	0	1	0	0	0	0	901	1435	50	0	3586	0	ARHGEF18	19	7535174	In_Frame_Del	DEL	TCT	TCGA-CN-5364-01A-01D-1434-08	1349569	7535174	51593809	139	12465											
PPAN-P2RY11	692312	broad.mit.edu	37	chr19	10221394	10221394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaagagcctggagggcatGaagaaggcacgggtcggggg	12	3	20	6	2	0	4	0	1	0	3	1	5	0	5	1	6	1	2	1	6	4	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:10221394G>A	uc002mna.2	+	11	1053	c.1053G>A	c.(1051-1053)ATG>ATA	p.M351I	PPAN-P2RY11_uc010xla.1_Missense_Mutation_p.M351I|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Missense_Mutation_p.M351I|PPAN_uc002mnb.1_Missense_Mutation_p.M298I	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	351					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TGGAGGGCATGAAGAAGGCAC	0.627													16	63					0	0	0	0	A	10221394	A	A	10221394	3	1	61	1	0	0	0	0	1	0	0	0	12344	1290	45	2	1095	2	PPAN-P2RY11	19	10221394	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	2686220	10221394	48907589	140	12466											
S1PR2	9294	broad.mit.edu	37	chr19	10335464	10335464	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgcaacagaggatgacgaTgaaggccgaggccacctggc	11	3	16	11	3	0	3	0	2	0	1	0	6	0	4	3	5	1	1	3	5	2	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:10335464T>A	uc002mnl.2	-	2	229	c.118A>T	c.(118-120)ATC>TTC	p.I40F		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	40	Helical; Name=1; (By similarity).				activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2						AGGATGACGATGAAGGCCGAG	0.552													43	235					0	0	0	0	A	10335464	A	A	10335464	3	1	61	1	0	0	0	0	1	0	0	0	13859	1464	51	5	947	5	S1PR2	19	10335464	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	114070	10335464	48793519	141	12467											
PKN1	5585	broad.mit.edu	37	chr19	14569141	14569141	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttggacaatgagaggcAtgaggtgcagctggacatgg	10	10	15	6	0	1	2	0	2	1	1	1	5	1	4	0	5	2	3	0	5	1	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:14569141A>T	uc002myp.2	+	9	1541	c.1373A>T	c.(1372-1374)CAT>CTT	p.H458L	PKN1_uc002myq.2_Missense_Mutation_p.H464L	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	458	C2.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8						AATGAGAGGCATGAGGTGCAG	0.577													10	77					0	0	0	0	T	14569141	T	T	14569141	3	4	61	1	0	0	0	0	1	0	0	0	12034	217	8	5	1450	5	PKN1	19	14569141	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	4233677	14569141	44559842	142	12468											
ZNF253	56242	broad.mit.edu	37	chr19	20003522	20003522	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaagaatgtgacagatctttTaaatgttcctccacttttaa	13	15	6	7	0	1	3	0	1	1	2	3	4	3	3	2	0	0	1	2	0	5	5			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:20003522T>C	uc002noj.2	+	4	1558	c.1466T>C	c.(1465-1467)TTA>TCA	p.L489S	ZNF253_uc002nok.2_Missense_Mutation_p.L413S|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	489					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACAGATCTTTTAAATGTTCCT	0.363													18	68					0	0	0	0	C	20003522	C	C	20003522	3	2	61	1	0	0	0	0	1	0	0	0	17864	1764	61	5	1480	5	ZNF253	19	20003522	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	5434381	20003522	39125461	143	12469											
ZNF536	9745	broad.mit.edu	37	chr19	30934639	30934639	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatccccggcccaaccccgAggagaagccccccgcatccc	8	2	8	23	3	0	1	0	0	0	1	2	3	2	1	10	2	2	1	10	2	2	0			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:30934639A>G	uc002nsu.1	+	2	308	c.170A>G	c.(169-171)GAG>GGG	p.E57G	ZNF536_uc010edd.1_Missense_Mutation_p.E57G	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCCAACCCCGAGGAGAAGCCC	0.677													21	88					0	0	0	0	G	30934639	G	G	30934639	3	3	61	1	0	0	0	0	1	0	0	0	18041	304	11	5	172	5	ZNF536	19	30934639	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	10931117	30934639	28194344	144	12470											
SHANK1	50944	broad.mit.edu	37	chr19	51165265	51165265	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagcccggtcgatgttcatgCggtggcccaccctggtcaca	6	8	13	14	3	2	0	2	0	0	0	3	2	2	0	3	4	2	1	3	4	0	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:51165265C>T	uc002psx.1	-	23	6462	c.6443G>A	c.(6442-6444)CGC>CAC	p.R2148H	SHANK1_uc002psw.1_Missense_Mutation_p.R1532H	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2148	SAM.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GATGTTCATGCGGTGGCCCAC	0.617													16	108					0	0	0	0	T	51165265	T	T	51165265	3	4	61	1	0	0	0	0	1	0	0	0	14329	768	27	1	46	1	SHANK1	19	51165265	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	20230626	51165265	7963718	145	12471											
ZNF667	63934	broad.mit.edu	37	chr19	56952944	56952944	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaggcttttccacattcctCacactggtagggtttttctc	7	15	8	11	0	2	0	1	0	1	0	5	1	4	0	2	3	0	3	2	3	2	6			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:56952944C>T	uc002qnd.2	-	5	1582	c.1420G>A	c.(1420-1422)GAG>AAG	p.E474K	ZNF667_uc010etl.2_Missense_Mutation_p.E256K|ZNF667_uc002qne.2_Missense_Mutation_p.E474K|ZNF667_uc010etm.2_Missense_Mutation_p.E417K	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	474	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CCACATTCCTCACACTGGTAG	0.398													20	102					0	0	0	0	T	56952944	T	T	56952944	3	4	61	1	0	0	0	0	1	0	0	0	18141	835	29	2	416	2	ZNF667	19	56952944	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	5787679	56952944	2176039	146	12472											
PEG3	5178	broad.mit.edu	37	chr19	57325748	57325748	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcttcttcttcttccagAtgaagctccttatgtttagt	6	20	5	10	0	5	2	0	1	5	1	7	2	7	2	2	0	1	2	2	0	3	8			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:57325748A>T	uc002qnu.2	-	7	4413	c.4062T>A	c.(4060-4062)CAT>CAA	p.H1354Q	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.H1325Q|PEG3_uc002qnv.2_Missense_Mutation_p.H1354Q|PEG3_uc002qnw.2_Missense_Mutation_p.H1230Q|PEG3_uc002qnx.2_Missense_Mutation_p.H1228Q|PEG3_uc010etr.2_Missense_Mutation_p.H1354Q	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1354	Glu-rich.|C2H2-type 10.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTTCTTCCAGATGAAGCTCCT	0.363													23	60					0	0	0	0	T	57325748	T	T	57325748	3	4	61	1	0	0	0	0	1	0	0	0	11774	330	12	5	708	5	PEG3	19	57325748	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	372804	57325748	1803235	147	12473											
ZNF264	9422	broad.mit.edu	37	chr19	57723539	57723539	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaaacacaggtcatatctCatgtggcaccagcagactca	13	9	7	12	0	4	1	4	0	1	1	5	1	4	1	1	2	2	2	1	2	2	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr19:57723539C>T	uc002qob.2	+	4	1487	c.1074C>T	c.(1072-1074)CTC>CTT	p.L358L		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	358	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		GGTCATATCTCATGTGGCACC	0.517													25	127					0	0	0	0	T	57723539	T	T	57723539	2	4	61	1	0	0	0	0	0	0	0	1	17871	813	29	2		2	ZNF264	19	57723539	Silent	SNP	C	TCGA-CN-5364-01A-01D-1434-08	397791	57723539	1405444	148	12474											
C20orf194	25943	broad.mit.edu	37	chr20	3321254	3321254	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggttttctcgtgtggagtgaTtaccaaagagaacaaatggc	12	11	12	6	1	1	2	0	1	1	1	2	4	1	3	1	3	2	1	1	3	4	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr20:3321254T>C	uc002wii.2	-	10	929	c.878A>G	c.(877-879)AAT>AGT	p.N293S	C20orf194_uc002wij.3_Missense_Mutation_p.N32S|C20orf194_uc002wik.2_5'UTR|C20orf194_uc010gay.1_RNA	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	293											0						TGTGGAGTGATTACCAAAGAG	0.493													8	44					0	0	0	0	C	3321254	C	C	3321254	3	2	61	1	0	0	0	0	1	0	0	0	2109	1493	52	5	2767	5	C20orf194	20	3321254	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08		3321254	59704266	149	12475											
FAM83C	128876	broad.mit.edu	37	chr20	33876620	33876620	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctccccattgaggtccaTcttgtagcacatctccagga	8	11	9	13	0	2	1	0	1	2	0	5	2	4	2	4	2	2	3	4	2	1	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr20:33876620T>C	uc010zux.1	-	2	773	c.655A>G	c.(655-657)ATG>GTG	p.M219V	FAM83C_uc002xcb.1_Missense_Mutation_p.M43V	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	219										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TTGAGGTCCATCTTGTAGCAC	0.642													8	61					0	0	0	0	C	33876620	C	C	33876620	3	2	61	1	0	0	0	0	1	0	0	0	5667	1435	50	5	1600	5	FAM83C	20	33876620	Missense_Mutation	SNP	T	TCGA-CN-5364-01A-01D-1434-08	30555366	33876620	29148900	150	12476											
CEP250	11190	broad.mit.edu	37	chr20	34054812	34054812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttcaagggctacctgaaaGgggagcacggtcgccttctc	8	9	12	12	2	3	1	1	1	2	0	5	2	3	2	2	4	2	2	2	4	3	3			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr20:34054812G>A	uc002xcm.2	+	9	1185	c.514G>A	c.(514-516)GGG>AGG	p.G172R	CEP250_uc010zve.1_5'UTR|CEP250_uc010gfe.1_RNA|CEP250_uc010zvd.1_RNA|CEP250_uc002xco.2_5'UTR	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	172					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CTACCTGAAAGGGGAGCACGG	0.527													23	98					0	0	0	0	A	34054812	A	A	34054812	3	1	61	1	0	0	0	0	1	0	0	0	3267	1000	35	4	532	4	CEP250	20	34054812	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	178192	34054812	28970708	151	12477											
CHAF1B	8208	broad.mit.edu	37	chr21	37783871	37783871	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttttggttacgtgtctaatAtacattaccacaccctcagt	10	15	5	11	1	2	0	1	0	1	0	2	0	2	0	2	1	3	1	2	1	5	7			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chr21:37783871A>T	uc002yvj.2	+	11	1168	c.1030A>T	c.(1030-1032)ATA>TTA	p.I344L		NM_005441	NP_005432	Q13112	CAF1B_HUMAN	chromatin assembly factor 1 subunit B	344	WD 7.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			ovary(1)|skin(1)	2						CGTGTCTAATATACATTACCA	0.537													61	229					0	0	0	0	T	37783871	T	T	37783871	3	4	61	1	0	0	0	0	1	0	0	0	3327	449	16	5	1068	5	CHAF1B	21	37783871	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08		37783871	10346024	152	12478											
FAM123B	139285	broad.mit.edu	37	chrX	63411781	63411781	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatcactattgggggcggaTtcttgctggtcactctgagg	6	13	13	9	1	5	1	3	1	2	0	5	2	5	2	0	5	1	1	0	5	1	4			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chrX:63411781T>C	uc004dvo.2	-	2	1659	c.1386A>G	c.(1384-1386)GAA>GAG	p.E462E		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	462					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						TGGGGGCGGATTCTTGCTGGT	0.547													15	23					0	0	0	0	C	63411781	C	C	63411781	2	2	61	1	0	0	0	0	0	0	0	1	5451	1490	52	5		5	FAM123B	23	63411781	Silent	SNP	T	TCGA-CN-5364-01A-01D-1434-08		63411781	91858779	153	12479											
HDX	139324	broad.mit.edu	37	chrX	83599378	83599378	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaagaaccagactcaggctGctcagagaaatcagcagggc	15	5	11	10	0	3	3	3	0	0	3	3	4	3	3	1	2	3	3	1	2	4	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chrX:83599378G>C	uc004eek.1	-	6	1649	c.1540C>G	c.(1540-1542)CAG>GAG	p.Q514E	HDX_uc011mqv.1_Missense_Mutation_p.Q514E|HDX_uc004eel.1_Missense_Mutation_p.Q456E	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	514						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GACTCAGGCTGCTCAGAGAAA	0.448													24	25					0	0	0	0	C	83599378	C	C	83599378	3	2	61	1	0	0	0	0	1	0	0	0	7065	1328	46	4	552	4	HDX	23	83599378	Missense_Mutation	SNP	G	TCGA-CN-5364-01A-01D-1434-08	20187597	83599378	71671182	154	12480											
CPXCR1	53336	broad.mit.edu	37	chrX	88008565	88008565	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtagaaaccaacccaataaaCagggagccaggcacagcaac	18	2	9	12	0	0	1	0	0	0	1	0	2	0	2	3	2	6	3	3	2	7	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chrX:88008565C>A	uc004efd.3	+	3	409	c.150C>A	c.(148-150)AAC>AAA	p.N50K	CPXCR1_uc004efc.3_Missense_Mutation_p.N50K	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	50						intracellular	zinc ion binding			ovary(3)	3						ACCCAATAAACAGGGAGCCAG	0.443													7	7					0.00198382	0.00205031	1	0	A	88008565	A	A	88008565	3	1	61	1	0	0	0	0	1	0	0	0	3851	477	17	4	152	4	CPXCR1	23	88008565	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	4409187	88008565	67261995	155	12481											
ESX1	80712	broad.mit.edu	37	chrX	103498950	103498950	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgggggctgtggtccctCagcggtttgtggcccctccg	1	11	15	14	2	2	0	1	0	1	0	4	0	4	0	4	5	1	2	4	5	0	1			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chrX:103498950C>T	uc004ely.2	-	2	449	c.391G>A	c.(391-393)GAG>AAG	p.E131K		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	131					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGTGGTCCCTCAGCGGTTTGT	0.647													4	27					0	0	0	0	T	103498950	T	T	103498950	3	4	61	1	0	0	0	0	1	0	0	0	5287	835	29	2	841	2	ESX1	23	103498950	Missense_Mutation	SNP	C	TCGA-CN-5364-01A-01D-1434-08	15490385	103498950	51771610	156	12482											
XPNPEP2	7512	broad.mit.edu	37	chrX	128881676	128881676	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacctggtatggggatcagAgaggccaccggttccaaatc	10	7	14	10	1	1	1	1	0	0	1	3	4	2	3	4	6	0	2	4	6	2	2			TCGA-CN-5364-01A-01D-1434-08	TCGA-CN-5364-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	22078e53-2c9e-4ae4-a166-34488f259ee8	61c617cf-d908-481e-ad7e-868408ce8e2c	g.chrX:128881676A>G	uc004eut.1	+	7	828	c.584A>G	c.(583-585)GAG>GGG	p.E195G	XPNPEP2_uc011mum.1_Missense_Mutation_p.E195G	NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	195					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						TGGGGATCAGAGAGGCCACCG	0.522													18	35					0	0	0	0	G	128881676	G	G	128881676	3	3	61	1	0	0	0	0	1	0	0	0	17511	304	11	5	610	5	XPNPEP2	23	128881676	Missense_Mutation	SNP	A	TCGA-CN-5364-01A-01D-1434-08	25382726	128881676	26388884	157	12483											
CSMD2	114784	broad.mit.edu	37	chr1	34117999	34117999	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctccttgcctggcgggtaggGttctgggtaatttggtgaga	5	13	16	7	1	1	1	0	1	1	1	2	2	2	1	2	5	1	3	2	5	2	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr1:34117999G>A	uc001bxn.1	-	28	4419	c.4390C>T	c.(4390-4392)CCC>TCC	p.P1464S	CSMD2_uc001bxm.1_Missense_Mutation_p.P1504S|CSMD2_uc001bxo.1_Missense_Mutation_p.P377S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1464	CUB 9.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGCGGGTAGGGTTCTGGGTAA	0.567													34	108					0	0	0	0	A	34117999	A	A	34117999	3	1	62	1	0	0	0	0	1	0	0	0	3962	1261	44	4	6241	4	CSMD2	1	34117999	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08		34117999	215132622	1	12484											
PDE4B	5142	broad.mit.edu	37	chr1	66379018	66379018	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaagaaaagcaggagtgtGatgacggtgatggctgatga	14	8	16	3	1	0	7	0	6	0	1	0	8	0	8	0	3	1	2	0	3	3	0			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr1:66379018G>T	uc001dcn.2	+	2	212	c.21G>T	c.(19-21)GTG>GTT	p.V7V	PDE4B_uc009war.2_5'UTR|PDE4B_uc001dco.2_Silent_p.V7V	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	7					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	GCAGGAGTGTGATGACGGTGA	0.393													33	95					1.8453e-21	2.21759e-21	1	0	T	66379018	T	T	66379018	2	4	62	1	0	0	0	0	0	0	0	1	11694	1277	45	2		2	PDE4B	1	66379018	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08	32261019	66379018	182871603	2	12485											
ELTD1	64123	broad.mit.edu	37	chr1	79385868	79385868	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agattaggatgcctacatacCttattagtatttgtattgat	12	17	7	5	0	0	2	0	1	0	1	0	3	0	3	2	1	3	2	2	1	7	9			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr1:79385868C>G	uc001diq.3	-	10	1617	c.1461G>C	c.(1459-1461)AAG>AAC	p.K487N		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	487	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GCCTACATACCTTATTAGTAT	0.313													18	67					0	0	0	0	G	79385868	G	G	79385868	3	3	62	1	0	0	0	0	1	0	0	0	5108	695	24	4	635	4	ELTD1	1	79385868	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	13006850	79385868	169864753	3	12486											
GSTM2	2946	broad.mit.edu	37	chr1	110211613	110211613	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggcctggactttcccaatgTaggtgcaggggaaggggcgg	7	7	19	8	1	0	0	0	0	0	0	1	2	1	2	2	8	1	2	2	8	3	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr1:110211613T>A	uc001dyi.2	+	3	491	c.177_splice	c.e3+2	p.N59_splice	GSTM2_uc001dyj.2_Splice_Site_p.N59_splice|GSTM2_uc010ovt.1_Splice_Site_p.N59_splice|GSTM2_uc009wfk.2_Splice_Site	NM_000848	NP_000839	P28161	GSTM2_HUMAN	glutathione S-transferase mu 2 isoform 1						glutathione metabolic process|xenobiotic catabolic process	cytoplasm	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	TTTCCCAATGTAGGTGCAGGG	0.517													20	106					0	0	0	0	A	110211613	A	A	110211613	5	1	62	1	0	0	0	0	0	0	1	0	6877	1652	57	5	189	5	GSTM2	1	110211613	Splice_Site	SNP	T	TCGA-CN-5365-01A-01D-1434-08	30825745	110211613	139039008	4	12487											
FLG	2312	broad.mit.edu	37	chr1	152279679	152279679	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctaaaactggatccccagttCctgcttgtcctgggcccctc	6	11	8	16	0	0	0	0	0	0	0	4	1	3	1	6	2	2	2	6	2	2	3	rs143745201		TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr1:152279679C>A	uc001ezu.1	-	3	7719	c.7683G>T	c.(7681-7683)AGG>AGT	p.R2561S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2561	Ser-rich.|Filaggrin 15.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.R2561R(1)		ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCCCCAGTTCCTGCTTGTCC	0.587									Ichthyosis				129	327					1.49341e-58	1.82676e-58	1	0	A	152279679	A	A	152279679	3	1	62	1	0	0	0	0	1	0	0	0	5954	854	30	2	4506	2	FLG	1	152279679	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	42068066	152279679	96970942	5	12488											
ATP1A2	477	broad.mit.edu	37	chr1	160100019	160100019	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagatcccgctcgacaaggAgatgcaagatgcctttcaaa	13	7	11	10	2	1	3	1	0	0	3	3	6	2	3	2	2	2	2	2	2	3	1			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr1:160100019A>G	uc001fvc.2	+	12	1721	c.1589A>G	c.(1588-1590)GAG>GGG	p.E530G	ATP1A2_uc001fvb.2_Missense_Mutation_p.E530G|ATP1A2_uc001fvd.2_Missense_Mutation_p.E266G|ATP1A2_uc009wtg.1_Missense_Mutation_p.E218G	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	530	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CTCGACAAGGAGATGCAAGAT	0.612													4	194					0	0	0	0	G	160100019	G	G	160100019	3	3	62	1	0	0	0	0	1	0	0	0	1131	304	11	5	1635	5	ATP1A2	1	160100019	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08	7820340	160100019	89150602	6	12489											
ASTN1	460	broad.mit.edu	37	chr1	176838011	176838011	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcctcacatcgccaggTgaattccccaaaactctcat	11	10	4	16	1	3	1	3	1	1	0	7	1	5	1	4	1	1	0	4	1	3	1			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr1:176838011T>G	uc001glc.2	-	22	3828	c.3616A>C	c.(3616-3618)ACC>CCC	p.T1206P	ASTN1_uc001glb.1_Missense_Mutation_p.T1206P|ASTN1_uc001gld.1_Missense_Mutation_p.T1206P	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1214					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CATCGCCAGGTGAATTCCCCA	0.473													8	142					0	0	0	0	G	176838011	G	G	176838011	3	3	62	1	0	0	0	0	1	0	0	0	1066	1696	59	5	280	5	ASTN1	1	176838011	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	16737992	176838011	72412610	7	12490											
ASPM	259266	broad.mit.edu	37	chr1	197070075	197070075	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agagtgcagattggttaacaAtggctgccatcttttcctct	9	14	9	9	0	2	2	0	0	2	2	3	2	3	2	2	2	3	3	2	2	2	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr1:197070075A>C	uc001gtu.2	-	18	8563	c.8306T>G	c.(8305-8307)ATT>AGT	p.I2769S	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.I617S	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2769					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTGGTTAACAATGGCTGCCAT	0.378													6	190					0	0	0	0	C	197070075	C	C	197070075	3	2	62	1	0	0	0	0	1	0	0	0	1058	101	4	5	2171	5	ASPM	1	197070075	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08	20232064	197070075	52180546	8	12491											
PCNXL2	80003	broad.mit.edu	37	chr1	233388475	233388475	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttttccttgcttagaacTgtgtccactgggcttttcat	5	18	9	9	0	1	1	1	0	0	1	3	1	3	1	2	2	2	3	2	2	2	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr1:233388475T>G	uc001hvl.2	-	6	2129	c.1894A>C	c.(1894-1896)AGT>CGT	p.S632R	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA|PCNXL2_uc001hvq.1_5'Flank	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	632						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TGCTTAGAACTGTGTCCACTG	0.408													7	161					0	0	0	0	G	233388475	G	G	233388475	3	3	62	1	0	0	0	0	1	0	0	0	11646	1580	55	5	4635	5	PCNXL2	1	233388475	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	36318400	233388475	15862146	9	12492											
CDKL4	344387	broad.mit.edu	37	chr2	39456583	39456583	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttccacaaattttttaacagCtactacttgtccagaggttt	11	16	5	9	0	0	1	0	0	0	1	2	1	2	1	2	1	4	2	2	1	4	8			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr2:39456583C>G	uc002rrm.2	-	1	91	c.91G>C	c.(91-93)GCT>CCT	p.A31P	CDKL4_uc010fal.1_Missense_Mutation_p.A31P	NM_001009565	NP_001009565	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4	31	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			ovary(1)	1		all_hematologic(82;0.248)				TTTTTAACAGCTACTACTTGT	0.323													4	199					0	0	0	0	G	39456583	G	G	39456583	3	3	62	1	0	0	0	0	1	0	0	0	3171	797	28	4	888	4	CDKL4	2	39456583	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08		39456583	203742790	10	12493											
MMADHC	27249	broad.mit.edu	37	chr2	150426656	150426656	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttcatcagtttcaaaaagAgtgttgtttgtatatggtcc	10	16	9	6	1	3	1	3	0	0	1	4	1	4	1	1	1	0	5	1	1	4	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr2:150426656A>T	uc002txb.2	-	7	1228	c.723T>A	c.(721-723)ACT>ACA	p.T241T	MMADHC_uc002txc.2_Silent_p.T241T|MMADHC_uc010fnu.2_Silent_p.T275T	NM_015702	NP_056517	Q9H3L0	MMAD_HUMAN	methylmalonic aciduria (cobalamin deficiency)	241						mitochondrion				central_nervous_system(1)|skin(1)	2						TTTCAAAAAGAGTGTTGTTTG	0.343													12	60					0	0	0	0	T	150426656	T	T	150426656	2	4	62	1	0	0	0	0	0	0	0	1	9695	291	11	5		5	MMADHC	2	150426656	Silent	SNP	A	TCGA-CN-5365-01A-01D-1434-08	110970073	150426656	92772717	11	12494											
NEB	4703	broad.mit.edu	37	chr2	152580789	152580789	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttaccttgctgaacatggcGgtgttcttaacggcctggac	7	12	11	11	2	1	1	0	1	1	0	1	2	1	2	2	4	4	2	2	4	3	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr2:152580789G>C	uc010fnx.2	-	8	788	c.597C>G	c.(595-597)ACC>ACG	p.T199T		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	199	Nebulin 4.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGAACATGGCGGTGTTCTTAA	0.453													7	31					0	0	0	0	C	152580789	C	C	152580789	2	2	62	1	0	0	0	0	0	0	0	1	10356	1103	39	3		3	NEB	2	152580789	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08	2154133	152580789	90618584	12	12495											
DCAF17	80067	broad.mit.edu	37	chr2	172309702	172309702	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctacctttttcacttgtaggGattctagagatcaacaaaaa	14	13	6	8	0	3	1	2	0	1	1	3	3	3	2	1	1	2	1	1	1	6	7			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr2:172309702G>T	uc002ugx.2	+	6	835	c.606G>T	c.(604-606)GGG>GGT	p.G202G	DCAF17_uc010zdq.1_RNA|DCAF17_uc010fqf.1_Silent_p.G202G|DCAF17_uc010zdr.1_RNA|DCAF17_uc010fqg.2_5'UTR	NM_025000	NP_079276	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17 isoform 1	202	Helical; (Potential).					CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus					0						CACTTGTAGGGATTCTAGAGA	0.328													6	112					8.12818e-05	8.83779e-05	1	0	T	172309702	T	T	172309702	2	4	62	1	0	0	0	0	0	0	0	1	4286	1161	41	2		2	DCAF17	2	172309702	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08	19728913	172309702	70889671	13	12496											
FAM126B	285172	broad.mit.edu	37	chr2	201881853	201881853	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taagtcgaacctctgagctaCgatagagctcaaacagctga	14	8	9	10	2	2	3	1	2	1	1	3	5	2	3	1	0	6	3	1	0	5	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr2:201881853C>G	uc002uws.3	-	5	382	c.194G>C	c.(193-195)CGT>CCT	p.R65P	FAM126B_uc002uwu.2_5'UTR|FAM126B_uc002uwv.2_Missense_Mutation_p.R65P|FAM126B_uc002uww.1_Missense_Mutation_p.R65P	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	65						intracellular				ovary(1)	1						CTCTGAGCTACGATAGAGCTC	0.423													8	81					0	0	0	0	G	201881853	G	G	201881853	3	3	62	1	0	0	0	0	1	0	0	0	5458	536	19	3	1430	3	FAM126B	2	201881853	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	29572151	201881853	41317520	14	12497											
B3GNT7	93010	broad.mit.edu	37	chr2	232263354	232263354	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggcttcctcatggccggcagCctggcccggcgcctgcacca	4	6	13	18	3	1	0	1	0	0	0	2	0	2	0	6	5	2	3	6	5	0	1			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr2:232263354C>T	uc002vrs.2	+	2	1104	c.924C>T	c.(922-924)AGC>AGT	p.S308S		NM_145236	NP_660279	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal	308	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		TGGCCGGCAGCCTGGCCCGGC	0.652													13	15					0	0	0	0	T	232263354	T	T	232263354	2	4	62	1	0	0	0	0	0	0	0	1	1264	738	26	4		4	B3GNT7	2	232263354	Silent	SNP	C	TCGA-CN-5365-01A-01D-1434-08	30381501	232263354	10936019	15	12498											
SETD2	29072	broad.mit.edu	37	chr3	47164649	47164649	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtctcagttttacagtcccGatcagatttagaataggatg	11	13	10	7	1	2	2	2	0	1	2	4	4	3	3	1	2	1	1	1	2	4	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr3:47164649G>A	uc003cqs.2	-	3	1530	c.1477C>T	c.(1477-1479)CGG>TGG	p.R493W	SETD2_uc003cqv.2_Missense_Mutation_p.R482W	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	493					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TTACAGTCCCGATCAGATTTA	0.383			N|F|S|Mis		clear cell renal carcinoma								3	46					0	0	0	0	A	47164649	A	A	47164649	3	1	62	1	0	0	0	0	1	0	0	0	14196	1057	37	1	6293	1	SETD2	3	47164649	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08		47164649	150857781	16	12499											
PBRM1	55193	broad.mit.edu	37	chr3	52651513	52651513	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcgagcttcaagaacaacaTtgaataagattttcattcgc	14	12	6	9	2	2	3	2	1	0	2	4	4	2	3	0	0	3	1	0	0	5	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr3:52651513T>A	uc003des.2	-	14	1595	c.1583A>T	c.(1582-1584)AAT>ATT	p.N528I	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.N528I|PBRM1_uc003der.2_Missense_Mutation_p.N496I|PBRM1_uc003det.2_Missense_Mutation_p.N543I|PBRM1_uc003deu.2_Missense_Mutation_p.N543I|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.N528I|PBRM1_uc010hmk.1_Missense_Mutation_p.N528I|PBRM1_uc003dey.2_Missense_Mutation_p.N528I|PBRM1_uc003dez.1_Missense_Mutation_p.N528I|PBRM1_uc003dfb.1_Missense_Mutation_p.N441I|PBRM1_uc003dfc.2_5'Flank	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	528					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AAGAACAACATTGAATAAGAT	0.348			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								33	51					0	0	0	0	A	52651513	A	A	52651513	3	1	62	1	0	0	0	0	1	0	0	0	11545	1493	52	5	3385	5	PBRM1	3	52651513	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	5486864	52651513	145370917	17	12500											
CADPS	8618	broad.mit.edu	37	chr3	62388773	62388773	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctttaccatcctaattaGtgttttcaactgataaatat	13	17	3	8	0	1	1	1	1	0	0	2	1	2	1	3	0	3	1	3	0	8	9			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr3:62388773G>T	uc003dll.2	-	29	4225	c.3865C>A	c.(3865-3867)CTA>ATA	p.L1289I	CADPS_uc003dlj.1_Missense_Mutation_p.L244I|CADPS_uc003dlk.1_Missense_Mutation_p.L737I|CADPS_uc003dlm.2_Missense_Mutation_p.L1250I|CADPS_uc003dln.2_Missense_Mutation_p.L1210I	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1289	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ATCCTAATTAGTGTTTTCAAC	0.373													14	35					0.00185496	0.00196999	1	0	T	62388773	T	T	62388773	3	4	62	1	0	0	0	0	1	0	0	0	2582	1020	36	4	204	4	CADPS	3	62388773	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	9737260	62388773	135633657	18	12501											
CCDC14	64770	broad.mit.edu	37	chr3	123633809	123633809	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcacagacagtattgcctttCacttgaaggctgttgctaag	10	13	9	9	0	2	2	2	1	0	1	2	2	2	2	1	1	2	4	1	1	3	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr3:123633809C>T	uc011bjx.1	-	13	2770	c.2679G>A	c.(2677-2679)GTG>GTA	p.V893V	CCDC14_uc003egv.3_Silent_p.V534V|CCDC14_uc003egx.3_Silent_p.V693V|CCDC14_uc010hrt.2_Silent_p.V852V|CCDC14_uc003egy.3_Silent_p.V693V|CCDC14_uc003egz.2_3'UTR	NM_022757	NP_073594	Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	893						centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		TATTGCCTTTCACTTGAAGGC	0.458													11	48					0	0	0	0	T	123633809	T	T	123633809	2	4	62	1	0	0	0	0	0	0	0	1	2785	813	29	2		2	CCDC14	3	123633809	Silent	SNP	C	TCGA-CN-5365-01A-01D-1434-08	61245036	123633809	74388621	19	12502											
PLCH1	23007	broad.mit.edu	37	chr3	155301387	155301387	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attttgtaaaaaacacagaaCtcttcaaatgtcaaagttcc	17	12	4	8	0	3	1	2	0	1	1	4	1	4	1	1	0	2	2	1	0	6	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr3:155301387C>T	uc011bok.1	-	5	886	c.609G>A	c.(607-609)GAG>GAA	p.E203E	PLCH1_uc011boj.1_Silent_p.E203E|PLCH1_uc011bol.1_Silent_p.E185E	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	203	EF-hand 2.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AAACACAGAACTCTTCAAATG	0.358													35	58					0	0	0	0	T	155301387	T	T	155301387	2	4	62	1	0	0	0	0	0	0	0	1	12092	564	20	4		4	PLCH1	3	155301387	Silent	SNP	C	TCGA-CN-5365-01A-01D-1434-08	31667578	155301387	42721043	20	12503											
ZBBX	79740	broad.mit.edu	37	chr3	167000124	167000124	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcattctggtcagtaataTcaatatattcaatttctgaa	13	16	5	7	0	6	1	4	1	2	0	6	1	6	1	0	1	0	2	0	1	7	7			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr3:167000124T>C	uc003fep.2	-	19	2362	c.2039A>G	c.(2038-2040)GAT>GGT	p.D680G	ZBBX_uc011bpc.1_Missense_Mutation_p.D719G|ZBBX_uc003feq.2_Missense_Mutation_p.D651G	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	680						intracellular	zinc ion binding			ovary(2)	2						GTCAGTAATATCAATATATTC	0.383													18	162					0	0	0	0	C	167000124	C	C	167000124	3	2	62	1	0	0	0	0	1	0	0	0	17584	1435	50	5	375	5	ZBBX	3	167000124	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	11698737	167000124	31022306	21	12504											
LRRC34	151827	broad.mit.edu	37	chr3	169514642	169514643	+	Frame_Shift_Del	DEL	AG	-	-																															catgtgtagtgcaacaagacAgtgattttctttcaacatgc																										TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr3:169514642_169514643delAG	uc003ffx.2	-	7	678_679	c.663_664delCT	c.(661-666)CACTGTfs	p.H221fs	LRRC34_uc003ffy.2_Frame_Shift_Del_p.H253fs|LRRC34_uc011bpn.1_Frame_Shift_Del_p.H253fs|LRRC34_uc003ffz.2_Frame_Shift_Del_p.H205fs|LRRC34_uc003fga.3_Frame_Shift_Del_p.H205fs	NM_153353	NP_699184	Q8IZ02	LRC34_HUMAN	leucine rich repeat containing 34	221_222											0	all_cancers(22;4.12e-22)|all_epithelial(15;7.54e-27)|all_lung(20;1.63e-16)|Lung NSC(18;6.92e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			GCAACAAGACAGTGATTTTCTT	0.351													---	---	---								-	169514643	-	-	169514642	7	5	62	1	0	1	0	1	0	0	0	0	9039	188	7	0	633	0	LRRC34	3	169514642	Frame_Shift_Del	DEL	AG	TCGA-CN-5365-01A-01D-1434-08	2514518	169514642	28507788	22	12505											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			20	122					0	0	0	0	A	178936091	A	A	178936091	3	1	62	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	9421449	178936091	19086339	23	12506											
BEND4	389206	broad.mit.edu	37	chr4	42145872	42145872	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgacagtgctcctgtctttcGttgtaacttgagccttcctg	5	16	9	11	1	1	2	0	2	1	0	4	2	3	2	3	0	3	3	3	0	1	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr4:42145872G>A	uc003gwn.2	-	3	1207	c.627C>T	c.(625-627)AAC>AAT	p.N209N	BEND4_uc003gwm.2_Silent_p.N209N|BEND4_uc011byy.1_Silent_p.N209N	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	209											0						CCTGTCTTTCGTTGTAACTTG	0.443													11	38					0	0	0	0	A	42145872	A	A	42145872	2	1	62	1	0	0	0	0	0	0	0	1	1402	1136	40	1		1	BEND4	4	42145872	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08		42145872	149008404	24	12507											
FAT4	79633	broad.mit.edu	37	chr4	126369690	126369690	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aactgcattattctctttcgGgtagaaattctgaaaaattt	13	16	6	6	1	2	2	0	1	2	1	4	2	2	2	0	1	2	2	0	1	6	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr4:126369690G>T	uc003ifj.3	+	9	7519	c.7519G>T	c.(7519-7521)GGT>TGT	p.G2507C	FAT4_uc011cgp.1_Missense_Mutation_p.G805C|FAT4_uc003ifi.1_5'UTR	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2507	Extracellular (Potential).|Cadherin 24.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TTCTCTTTCGGGTAGAAATTC	0.423													9	129					2.17888e-05	2.38805e-05	1	0	T	126369690	T	T	126369690	3	4	62	1	0	0	0	0	1	0	0	0	5724	1232	43	4	7553	4	FAT4	4	126369690	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	84223818	126369690	64784586	25	12508											
NPY5R	4889	broad.mit.edu	37	chr4	164272513	164272513	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaagaataaaaaagagatCtcgaagtgttttctacagac	18	10	7	6	1	2	3	0	0	2	3	3	5	2	3	0	0	2	1	0	0	8	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr4:164272513C>A	uc003iqn.2	+	4	1270	c.1088C>A	c.(1087-1089)TCT>TAT	p.S363Y		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	363	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				AAAAAGAGATCTCGAAGTGTT	0.358													16	110					0.000422831	0.000452562	1	0	A	164272513	A	A	164272513	3	1	62	1	0	0	0	0	1	0	0	0	10664	913	32	2	1090	2	NPY5R	4	164272513	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	37902823	164272513	26881763	26	12509											
PRDM9	56979	broad.mit.edu	37	chr5	23510109	23510109	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgacacagaagattctGatgaagaatggacccctagg	14	8	12	7	0	1	6	0	3	1	3	1	8	1	8	2	3	0	0	2	3	4	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr5:23510109G>T	uc003jgo.2	+	4	456	c.274G>T	c.(274-276)GAT>TAT	p.D92Y		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	92					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGAAGATTCTGATGAAGAATG	0.363										HNSCC(3;0.000094)			11	85					2.80697e-09	3.2868e-09	1	0	T	23510109	T	T	23510109	3	4	62	1	0	0	0	0	1	0	0	0	12525	1290	45	2	284	2	PRDM9	5	23510109	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08		23510109	157405151	27	12510											
FYB	2533	broad.mit.edu	37	chr5	39110492	39110492	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actccgaaggacataaccatCtacgaaggaaaaaggaaata	20	5	8	8	2	1	0	0	0	1	0	2	5	2	3	2	3	2	0	2	3	8	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr5:39110492C>G	uc003jls.2	-	15	2331	c.2264_splice	c.e15-1	p.Y755_splice	FYB_uc003jlt.2_Splice_Site_p.Y801_splice|FYB_uc003jlu.2_Splice_Site_p.Y755_splice|FYB_uc011cpl.1_Splice_Site_p.Y811_splice	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2						cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			ACATAACCATCTACGAAGGAA	0.308													5	49					0	0	0	0	G	39110492	G	G	39110492	5	3	62	1	0	0	0	0	0	0	1	0	6158	927	32	2	100	2	FYB	5	39110492	Splice_Site	SNP	C	TCGA-CN-5365-01A-01D-1434-08	15600383	39110492	141804768	28	12511											
CARD6	84674	broad.mit.edu	37	chr5	40854367	40854367	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaaaatcctgtcagtcccAgccctcccaaactaaacctt	13	8	4	16	0	1	0	1	0	0	0	4	1	4	0	5	0	3	0	5	0	5	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr5:40854367A>T	uc003jmg.2	+	3	3008	c.2933A>T	c.(2932-2934)CAG>CTG	p.Q978L		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	978	Pro-rich.				apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						TGTCAGTCCCAGCCCTCCCAA	0.532													12	513					0	0	0	0	T	40854367	T	T	40854367	3	4	62	1	0	0	0	0	1	0	0	0	2662	188	7	5	2943	5	CARD6	5	40854367	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08	1743875	40854367	140060893	29	12512											
ZFYVE16	9765	broad.mit.edu	37	chr5	79734565	79734565	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagataccgttgttccaatCacttgtgctatagattctac	10	14	7	10	1	2	2	1	0	1	2	3	2	3	2	2	0	3	4	2	0	5	8			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr5:79734565C>T	uc003kgr.3	+	4	2363	c.2061C>T	c.(2059-2061)ATC>ATT	p.I687I	ZFYVE16_uc010jak.1_Silent_p.I687I|ZFYVE16_uc003kgp.2_Silent_p.I687I|ZFYVE16_uc003kgq.3_Silent_p.I687I|ZFYVE16_uc003kgs.3_Silent_p.I687I	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	687					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TTGTTCCAATCACTTGTGCTA	0.403													4	128					0	0	0	0	T	79734565	T	T	79734565	2	4	62	1	0	0	0	0	0	0	0	1	17731	816	29	2		2	ZFYVE16	5	79734565	Silent	SNP	C	TCGA-CN-5365-01A-01D-1434-08	38880198	79734565	101180695	30	12513											
RIOK2	55781	broad.mit.edu	37	chr5	96503521	96503521	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgttcactttcattttctgaCccgtaaacctctgctttttc	6	18	4	13	2	4	1	2	1	2	0	5	1	4	1	2	0	2	3	2	0	2	7			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr5:96503521C>G	uc003kmz.2	-	8	1157	c.1047G>C	c.(1045-1047)GGG>GGC	p.G349G	RIOK2_uc003kna.3_Silent_p.G349G	NM_018343	NP_060813	Q9BVS4	RIOK2_HUMAN	RIO kinase 2 isoform 1	349	Protein kinase.						ATP binding|protein serine/threonine kinase activity			kidney(1)	1		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		CATTTTCTGACCCGTAAACCT	0.393													50	279					0	0	0	0	G	96503521	G	G	96503521	2	3	62	1	0	0	0	0	0	0	0	1	13443	494	18	4		4	RIOK2	5	96503521	Silent	SNP	C	TCGA-CN-5365-01A-01D-1434-08	16768956	96503521	84411739	31	12514											
VDAC1	7416	broad.mit.edu	37	chr5	133326807	133326807	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccagactgcccgtcactttGgtggtctcagtgttggctga	5	13	12	11	1	2	2	2	1	1	1	4	2	3	2	2	3	1	2	2	3	0	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr5:133326807G>C	uc003kyp.1	-	4	255	c.156C>G	c.(154-156)ACC>ACG	p.T52T	VDAC1_uc003kyq.1_Silent_p.T52T|VDAC1_uc003kyr.1_Silent_p.T52T	NM_003374	NP_003365	P21796	VDAC1_HUMAN	voltage-dependent anion channel 1	52					apoptosis|interspecies interaction between organisms	mitochondrial nucleoid|mitochondrial outer membrane|plasma membrane|pore complex	porin activity|protein binding|voltage-gated anion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)		Dihydroxyaluminium(DB01375)	CCGTCACTTTGGTGGTCTCAG	0.488													32	167					0	0	0	0	C	133326807	C	C	133326807	2	2	62	1	0	0	0	0	0	0	0	1	17214	1335	47	4		4	VDAC1	5	133326807	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08	36823286	133326807	47588453	32	12515											
PCDHGA5	56110	broad.mit.edu	37	chr5	140746136	140746136	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgtgggcgtggatggggttCgggctttcctgcagacctat	4	13	16	8	2	0	1	0	0	0	1	2	2	1	2	2	5	1	3	2	5	1	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr5:140746136C>T	uc003lju.1	+	1	2239	c.2239C>T	c.(2239-2241)CGG>TGG	p.R747W	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.R747W	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	747	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATGGGGTTCGGGCTTTCCT	0.627													49	125					0	0	0	0	T	140746136	T	T	140746136	3	4	62	1	0	0	0	0	1	0	0	0	11611	875	31	1	2241	1	PCDHGA5	5	140746136	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	7419329	140746136	40169124	33	12516											
SERPINB6	5269	broad.mit.edu	37	chr6	2953378	2953378	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccagaaccagccttgtcAatggatccactgagcccgga	11	7	9	14	1	2	2	2	1	0	1	3	4	3	4	5	2	3	0	5	2	2	1			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr6:2953378A>C	uc003muk.2	-	4	2468	c.473T>G	c.(472-474)TTG>TGG	p.L158W	SERPINB6_uc003mui.2_Missense_Mutation_p.L41W|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Missense_Mutation_p.L158W|SERPINB6_uc003mum.2_Missense_Mutation_p.L158W|SERPINB6_uc003mun.2_Missense_Mutation_p.L158W|SERPINB6_uc003muo.2_Missense_Mutation_p.L158W	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	158					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	CAGCCTTGTCAATGGATCCAC	0.502											OREG0017145	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	475					0	0	0	0	C	2953378	C	C	2953378	3	2	62	1	0	0	0	0	1	0	0	0	14170	131	5	5	669	5	SERPINB6	6	2953378	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08		2953378	168161689	34	12517											
OR2J2	26707	broad.mit.edu	37	chr6	29141542	29141542	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgacactgacaggaaacCtgttcatcatcatcctgtca	12	11	7	11	0	4	3	4	3	0	0	5	4	5	4	2	1	1	1	2	1	1	1			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr6:29141542C>G	uc011dlm.1	+	1	232	c.130C>G	c.(130-132)CTG>GTG	p.L44V		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GACAGGAAACCTGTTCATCAT	0.428													57	315					0	0	0	0	G	29141542	G	G	29141542	3	3	62	1	0	0	0	0	1	0	0	0	11057	680	24	4	132	4	OR2J2	6	29141542	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	26188164	29141542	141973525	35	12518											
MUC21	394263	broad.mit.edu	37	chr6	30954441	30954441	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaacctccagtgaggccagCacagccaccaactctgagtc	12	5	8	16	0	1	2	0	2	1	0	3	2	2	2	5	1	4	1	5	1	2	0			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr6:30954441C>T	uc003nsh.2	+	2	740	c.489C>T	c.(487-489)AGC>AGT	p.S163S	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	163	Ser-rich.|28 X 15 AA approximate tandem repeats.|9.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GTGAGGCCAGCACAGCCACCA	0.617													71	290					0	0	0	0	T	30954441	T	T	30954441	2	4	62	1	0	0	0	0	0	0	0	1	10030	709	25	4		4	MUC21	6	30954441	Silent	SNP	C	TCGA-CN-5365-01A-01D-1434-08	1812899	30954441	140160626	36	12519			1	17		2	2	15	C		4.52234e-05
MUC21	394263	broad.mit.edu	37	chr6	30954455	30954455	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccagcacagccaccaactCtgagtccagcacaacctcca	12	4	7	18	0	1	1	0	1	1	0	3	1	3	1	6	1	5	2	6	1	2	0			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr6:30954455C>G	uc003nsh.2	+	2	754	c.503C>G	c.(502-504)TCT>TGT	p.S168C	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	168	28 X 15 AA approximate tandem repeats.|Ser-rich.|10.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GCCACCAACTCTGAGTCCAGC	0.607													77	317					0	0	0	0	G	30954455	G	G	30954455	3	3	62	1	0	0	0	0	1	0	0	0	10030	913	32	2	509	2	MUC21	6	30954455	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	14	30954455	140160612	37	12520			1	17		2	2	15	C		4.52234e-05
C6orf26	401251	broad.mit.edu	37	chr6	31731931	31731931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttgcagaatctgattcatGagaaggtgagtttattgttt	10	17	11	3	0	2	4	1	3	1	2	2	5	2	4	0	1	1	4	0	1	3	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr6:31731931G>A	uc003nxa.3	+	3	405	c.346G>A	c.(346-348)GAG>AAG	p.E116K	MSH5_uc003nwz.3_RNA	NM_001039651	NP_001034740	Q5SSQ6	G7D_HUMAN	hypothetical protein LOC401251	116											0						TCTGATTCATGAGAAGGTGAG	0.443													27	227					0	0	0	0	A	31731931	A	A	31731931	3	1	62	1	0	0	0	0	1	0	0	0	2371	1291	45	2	356	2	C6orf26	6	31731931	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	777476	31731931	139383136	38	12521											
MEP1A	4224	broad.mit.edu	37	chr6	46802421	46802421	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctggagtggtttcatttcCcaccaaatgctgaaaaggag	11	10	12	8	0	1	1	1	1	0	0	2	3	2	3	2	4	1	3	2	4	3	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr6:46802421C>G	uc010jzh.1	+	12	1758	c.1716C>G	c.(1714-1716)TCC>TCG	p.S572S	MEP1A_uc011dwg.1_Silent_p.S294S|MEP1A_uc011dwh.1_Silent_p.S600S|MEP1A_uc011dwi.1_Silent_p.S472S	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	572	MATH.|Extracellular (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			GTTTCATTTCCCACCAAATGC	0.438													6	183					0	0	0	0	G	46802421	G	G	46802421	2	3	62	1	0	0	0	0	0	0	0	1	9528	610	22	4		4	MEP1A	6	46802421	Silent	SNP	C	TCGA-CN-5365-01A-01D-1434-08	15070490	46802421	124312646	39	12522											
SLC22A16	85413	broad.mit.edu	37	chr6	110763885	110763885	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagggttccaactgcaaaaaAggaatgcaaatggacagacg	17	5	11	8	1	0	1	0	0	0	1	1	3	1	3	1	3	3	3	1	3	6	1			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr6:110763885A>C	uc003puf.2	-	4	812	c.745T>G	c.(745-747)TTT>GTT	p.F249V	SLC22A16_uc003pue.2_Missense_Mutation_p.F230V	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	249	Helical; (Potential).				acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		ACTGCAAAAAAGGAATGCAAA	0.483													24	80					0	0	0	0	C	110763885	C	C	110763885	3	2	62	1	0	0	0	0	1	0	0	0	14512	72	3	5	1008	5	SLC22A16	6	110763885	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08	63961464	110763885	60351182	40	12523											
NKAIN2	154215	broad.mit.edu	37	chr6	124979372	124979372	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttaatatatcaatgcaccGatcttggtggatggagaatg	12	14	10	5	1	2	1	1	0	1	1	2	4	2	2	1	3	1	1	1	3	5	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr6:124979372G>A	uc003pzo.2	+	4	591	c.314G>A	c.(313-315)CGA>CAA	p.R105Q	NKAIN2_uc003pzn.1_Missense_Mutation_p.R105Q|NKAIN2_uc003pzp.2_Missense_Mutation_p.R104Q|NKAIN2_uc010keq.2_Intron|NKAIN2_uc010ker.2_Missense_Mutation_p.R15Q	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	105						integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		TCAATGCACCGATCTTGGTGG	0.463													20	95					0	0	0	0	A	124979372	A	A	124979372	3	1	62	1	0	0	0	0	1	0	0	0	10490	1058	37	1	328	1	NKAIN2	6	124979372	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	14215487	124979372	46135695	41	12524											
RAET1E	135250	broad.mit.edu	37	chr6	150210664	150210664	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttcattgcgtcaaagaggaGggatttctctccattggtgg	8	13	13	7	1	3	1	2	0	1	1	5	3	4	3	1	4	1	1	1	4	1	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr6:150210664G>T	uc003qnl.1	-	3	502	c.442C>A	c.(442-444)CTC>ATC	p.L148I	uc003qni.1_Intron|RAET1E_uc003qnj.2_Missense_Mutation_p.L148I|RAET1E_uc003qnk.1_Missense_Mutation_p.L112I|RAET1E_uc010kih.1_RNA	NM_139165	NP_631904	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E precursor	148	Extracellular (Potential).|MHC class I alpha-2 like.				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		TCAAAGAGGAGGGATTTCTCT	0.468													6	162					1.12685e-05	1.24499e-05	1	0	T	150210664	T	T	150210664	3	4	62	1	0	0	0	0	1	0	0	0	13064	1000	35	4	357	4	RAET1E	6	150210664	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	25231292	150210664	20904403	42	12525											
MTRF1L	54516	broad.mit.edu	37	chr6	153316432	153316432	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattttcatctgtttcttctGagggaaccaaaagtaagata	13	14	7	7	0	4	2	1	1	3	1	4	3	4	3	1	1	1	2	1	1	5	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr6:153316432G>A	uc003qpi.3	-	3	467	c.362C>T	c.(361-363)TCA>TTA	p.S121L	MTRF1L_uc003qpl.3_Missense_Mutation_p.S121L|MTRF1L_uc011efa.1_Missense_Mutation_p.S121L|MTRF1L_uc003qpj.3_Intron|MTRF1L_uc003qpk.3_Missense_Mutation_p.S121L	NM_019041	NP_061914	Q9UGC7	RF1ML_HUMAN	mitochondrial translational release factor	121						mitochondrion	translation release factor activity, codon specific				0		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.24e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0888)		TGTTTCTTCTGAGGGAACCAA	0.303													5	48					0	0	0	0	A	153316432	A	A	153316432	3	1	62	1	0	0	0	0	1	0	0	0	10013	1294	45	2	800	2	MTRF1L	6	153316432	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	3105768	153316432	17798635	43	12526											
THSD7A	221981	broad.mit.edu	37	chr7	11464388	11464388	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcacaaaggtcaccttgcaGatgctccagggctctgtgac	9	10	10	12	0	3	2	2	1	1	1	4	2	4	2	2	2	2	3	2	2	1	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr7:11464388G>A	uc003ssf.3	-	15	3570	c.3318C>T	c.(3316-3318)ATC>ATT	p.I1106I		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1106	TSP type-1 11.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TCACCTTGCAGATGCTCCAGG	0.493										HNSCC(18;0.044)			43	265					0	0	0	0	A	11464388	A	A	11464388	2	1	62	1	0	0	0	0	0	0	0	1	15945	932	33	2		2	THSD7A	7	11464388	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08		11464388	147674275	44	12527											
SEMA3A	10371	broad.mit.edu	37	chr7	83590840	83590840	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttccaaacttgttcacaGaactcatccattgtgttgag	10	15	6	10	0	2	2	2	1	0	1	4	2	4	2	2	0	2	2	2	0	2	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr7:83590840G>A	uc003uhz.2	-	17	2478	c.2163C>T	c.(2161-2163)TTC>TTT	p.F721F		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	721					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						CTTGTTCACAGAACTCATCCA	0.453													16	176					0	0	0	0	A	83590840	A	A	83590840	2	1	62	1	0	0	0	0	0	0	0	1	14089	933	33	2		2	SEMA3A	7	83590840	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08	72126452	83590840	75547823	45	12528											
GRM3	2913	broad.mit.edu	37	chr7	86394556	86394556	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccataactttctaaggagagAgattaaaatagaaggtgacc	17	9	9	6	0	1	4	0	1	1	3	1	6	1	4	2	2	1	0	2	2	6	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr7:86394556A>G	uc003uid.2	+	2	1194	c.95A>G	c.(94-96)GAG>GGG	p.E32G	GRM3_uc010lef.2_Missense_Mutation_p.E30G|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	32	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CTAAGGAGAGAGATTAAAATA	0.408													7	204					0	0	0	0	G	86394556	G	G	86394556	3	3	62	1	0	0	0	0	1	0	0	0	6837	304	11	5	97	5	GRM3	7	86394556	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08	2803716	86394556	72744107	46	12529											
INSIG1	3638	broad.mit.edu	37	chr7	155093339	155093339	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaccccacaaatttaagaGagaatgggccagtgtcatgc	15	7	10	9	0	1	3	1	0	0	3	1	4	1	3	3	1	2	0	3	1	4	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr7:155093339G>C	uc003wly.2	+	3	687	c.476G>C	c.(475-477)AGA>ACA	p.R159T	INSIG1_uc011kvu.1_Intron|INSIG1_uc003wlz.2_Intron	NM_005542	NP_005533	O15503	INSI1_HUMAN	insulin induced gene 1 isoform 1	159	Cytoplasmic.				cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAATTTAAGAGAGAATGGGCC	0.443													79	197					0	0	0	0	C	155093339	C	C	155093339	3	2	62	1	0	0	0	0	1	0	0	0	7804	942	33	2	482	2	INSIG1	7	155093339	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	68698783	155093339	4045324	47	12530											
ADRB3	155	broad.mit.edu	37	chr8	37823588	37823588	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtcacagccaggtagcggtCcacggccagggcgcacaggg	8	3	17	13	3	1	0	1	0	0	0	2	0	2	0	3	6	2	2	3	6	1	1			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr8:37823588C>A	uc003xkr.1	-	1	597	c.400G>T	c.(400-402)GAC>TAC	p.D134Y		NM_000025	NP_000016	P13945	ADRB3_HUMAN	adrenergic, beta-3-, receptor	134	Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process|positive regulation of MAPKKK cascade	integral to plasma membrane|receptor complex	beta3-adrenergic receptor activity|protein homodimerization activity			lung(2)	2	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)		Norepinephrine(DB00368)|Pindolol(DB00960)|Propranolol(DB00571)	AGGTAGCGGTCCACGGCCAGG	0.692													8	10					1.12685e-05	1.24499e-05	1	0	A	37823588	A	A	37823588	3	1	62	1	0	0	0	0	1	0	0	0	342	855	30	2	834	2	ADRB3	8	37823588	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08		37823588	108540434	48	12531											
STK3	6788	broad.mit.edu	37	chr8	99468078	99468078	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggaaattagactcaaaagtTttgctgccttcttttctttg	10	17	7	7	0	3	1	1	0	2	1	3	2	3	2	1	1	2	2	1	1	4	7			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr8:99468078T>G	uc003yip.2	-	11	1609	c.1468A>C	c.(1468-1470)AAC>CAC	p.N490H	STK3_uc003yio.2_Missense_Mutation_p.N518H	NM_006281	NP_006272	Q13188	STK3_HUMAN	serine/threonine kinase 3	490					apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		ACTCAAAAGTTTTGCTGCCTT	0.388													6	55					0	0	0	0	G	99468078	G	G	99468078	3	3	62	1	0	0	0	0	1	0	0	0	15361	1841	64	5	11	5	STK3	8	99468078	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	61644490	99468078	46895944	49	12532											
NOTCH1	4851	broad.mit.edu	37	chr9	139413947	139413947	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgttcacgccgtccacacaGgcacccccgttcttgcagtt	6	10	9	16	3	2	0	1	0	1	0	3	0	3	0	4	1	1	5	4	1	0	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr9:139413947G>A	uc004chz.2	-	5	813	c.813C>T	c.(811-813)GCC>GCT	p.A271A		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	271	Extracellular (Potential).|EGF-like 7; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGTCCACACAGGCACCCCCGT	0.647			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			41	126					0	0	0	0	A	139413947	A	A	139413947	2	1	62	1	0	0	0	0	0	0	0	1	10601	987	35	4		4	NOTCH1	9	139413947	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08		139413947	1799484	50	12533											
PNPLA7	375775	broad.mit.edu	37	chr9	140361788	140361788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcggcccactgcttggccCggatccgcatctggctgtag	4	9	12	16	3	1	0	0	0	1	0	3	1	2	1	4	4	1	4	4	4	1	2	rs28415505		TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr9:140361788C>T	uc004cnf.2	-	25	3282	c.2945G>A	c.(2944-2946)CGG>CAG	p.R982Q	C9orf167_uc011mew.1_Intron|PNPLA7_uc004cnd.1_Missense_Mutation_p.R248Q|PNPLA7_uc004cne.1_Missense_Mutation_p.R248Q|PNPLA7_uc011mfa.1_Missense_Mutation_p.R390Q|PNPLA7_uc010ncj.1_Missense_Mutation_p.R1007Q	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	982	Patatin.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		CTGCTTGGCCCGGATCCGCAT	0.672													18	39					0	0	0	0	T	140361788	T	T	140361788	3	4	62	1	0	0	0	0	1	0	0	0	12225	652	23	1	1048	1	PNPLA7	9	140361788	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	947841	140361788	851643	51	12534											
ZNF518A	9849	broad.mit.edu	37	chr10	97919954	97919954	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaagaacctccaagaagaaAagcaacattgcatagaaagt	20	5	7	9	0	0	4	0	0	0	4	1	4	1	4	3	0	4	2	3	0	9	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr10:97919954A>T	uc001klp.2	+	6	4732	c.3875A>T	c.(3874-3876)AAA>ATA	p.K1292I	ZNF518A_uc001klo.1_Missense_Mutation_p.K762I|ZNF518A_uc001klq.2_Missense_Mutation_p.K1292I|ZNF518A_uc001klr.2_Missense_Mutation_p.K1292I	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		CCAAGAAGAAAAGCAACATTG	0.373													7	23					0	0	0	0	T	97919954	T	T	97919954	3	4	62	1	0	0	0	0	1	0	0	0	18029	14	1	5	3877	5	ZNF518A	10	97919954	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08		97919954	37614793	52	12535											
EIF3A	8661	broad.mit.edu	37	chr10	120809363	120809363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctctcttcctctctacgccGttctcgttcttcaatttcca	4	18	3	16	3	6	0	1	0	5	0	11	0	8	0	3	0	1	2	3	0	2	6	rs150064739		TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr10:120809363G>A	uc001ldu.2	-	17	2754	c.2608C>T	c.(2608-2610)CGG>TGG	p.R870W	EIF3A_uc010qsu.1_Missense_Mutation_p.R836W|EIF3A_uc009xzg.1_Translation_Start_Site	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	870	Glu-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TCTCTACGCCGTTCTCGTTCT	0.403													103	274					0	0	0	0	A	120809363	A	A	120809363	3	1	62	1	0	0	0	0	1	0	0	0	5034	1144	40	1	1564	1	EIF3A	10	120809363	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	22889409	120809363	14725384	53	12536											
EIF3A	8661	broad.mit.edu	37	chr10	120820798	120820798	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaagccaattgtaaaggtCtttcacttctgggacaacat	12	13	7	9	0	4	0	2	0	2	0	4	1	4	1	1	2	2	1	1	2	5	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr10:120820798C>A	uc001ldu.2	-	8	1311	c.1165G>T	c.(1165-1167)GAC>TAC	p.D389Y	EIF3A_uc010qsu.1_Missense_Mutation_p.D355Y|SNORA19_uc001ldv.2_5'Flank	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	389	PCI.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TTGTAAAGGTCTTTCACTTCT	0.348													19	92					8.00594e-06	9.06458e-06	1	0	A	120820798	A	A	120820798	3	1	62	1	0	0	0	0	1	0	0	0	5034	913	32	2	3043	2	EIF3A	10	120820798	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	11435	120820798	14713949	54	12537											
ACADSB	36	broad.mit.edu	37	chr10	124800144	124800144	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgattagaaaacatggaacaGaagaacaaaaggccacctat	20	6	8	7	0	0	4	0	1	0	3	0	5	0	5	2	2	3	0	2	2	9	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr10:124800144G>T	uc001lhb.2	+	4	583	c.466G>T	c.(466-468)GAA>TAA	p.E156*	ACADSB_uc010qub.1_Nonsense_Mutation_p.E54*	NM_001609	NP_001600	P45954	ACDSB_HUMAN	acyl-Coenzyme A dehydrogenase, short/branched	156					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	ACATGGAACAGAAGAACAAAA	0.368													14	135					2.23348e-06	2.57132e-06	1	0	T	124800144	T	T	124800144	4	4	62	1	0	0	0	0	0	1	0	0	115	943	33	2	480	2	ACADSB	10	124800144	Nonsense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	3979346	124800144	10734603	55	12538											
OR5L2	26338	broad.mit.edu	37	chr11	55594746	55594746	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcattctccttggactaTcagatgtccctgagttgaga	9	14	9	9	0	3	3	2	2	1	2	5	5	4	4	2	1	0	2	2	1	1	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr11:55594746T>C	uc001nhy.1	+	1	52	c.52T>C	c.(52-54)TCA>CCA	p.S18P		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CCTTGGACTATCAGATGTCCC	0.453										HNSCC(27;0.073)			17	393					0	0	0	0	C	55594746	C	C	55594746	3	2	62	1	0	0	0	0	1	0	0	0	11225	1435	50	5	54	5	OR5L2	11	55594746	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08		55594746	79411770	56	12539											
OR5L2	26338	broad.mit.edu	37	chr11	55595025	55595025	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgcacatgtggagtcactGaggtcttcctgctggccgtg	5	13	13	10	1	2	1	1	1	1	0	3	2	3	2	2	3	2	2	2	3	0	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr11:55595025G>A	uc001nhy.1	+	1	331	c.331G>A	c.(331-333)GAG>AAG	p.E111K		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TGGAGTCACTGAGGTCTTCCT	0.502										HNSCC(27;0.073)			55	223					0	0	0	0	A	55595025	A	A	55595025	3	1	62	1	0	0	0	0	1	0	0	0	11225	1291	45	2	333	2	OR5L2	11	55595025	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	279	55595025	79411491	57	12540											
OR5T3	390154	broad.mit.edu	37	chr11	56020106	56020106	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaactacagaatgttttcTcttggctgcaatggcttatg	9	15	10	7	0	1	1	0	0	1	1	2	2	1	2	0	3	3	4	0	3	5	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr11:56020106T>C	uc010rjd.1	+	1	431	c.431T>C	c.(430-432)CTC>CCC	p.L144P		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	144	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					GAATGTTTTCTCTTGGCTGCA	0.403													115	226					0	0	0	0	C	56020106	C	C	56020106	3	2	62	1	0	0	0	0	1	0	0	0	11237	1551	54	5	433	5	OR5T3	11	56020106	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	425081	56020106	78986410	58	12541											
ANKRD42	338699	broad.mit.edu	37	chr11	82935940	82935940	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caccttcactgtttcaaattCctagtcagtagaatgagcag	12	12	7	10	0	3	2	3	1	0	1	4	2	4	2	2	0	1	3	2	0	4	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr11:82935940C>G	uc001ozz.1	+	6	968	c.546C>G	c.(544-546)TTC>TTG	p.F182L	ANKRD42_uc010rsv.1_Missense_Mutation_p.F210L|ANKRD42_uc001paa.2_Missense_Mutation_p.F210L|ANKRD42_uc001pab.1_Missense_Mutation_p.F209L	NM_182603	NP_872409	Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	182	ANK 5.									skin(1)	1						GTTTCAAATTCCTAGTCAGTA	0.343													3	138					0	0	0	0	G	82935940	G	G	82935940	3	3	62	1	0	0	0	0	1	0	0	0	670	854	30	2	568	2	ANKRD42	11	82935940	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	26915834	82935940	52070576	59	12542											
A2ML1	144568	broad.mit.edu	37	chr12	9021749	9021749	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcttctccagcaacccctgGtgaagaaggttgaatttgga	11	10	11	9	0	1	3	0	2	1	1	2	4	1	4	3	3	3	3	3	3	4	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr12:9021749G>C	uc001quz.3	+	33	4269	c.4171G>C	c.(4171-4173)GTG>CTG	p.V1391L	A2ML1_uc001qva.1_Missense_Mutation_p.V971L|A2ML1_uc010sgm.1_Missense_Mutation_p.V891L|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1235						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GCAACCCCTGGTGAAGAAGGT	0.443													13	238					0	0	0	0	C	9021749	C	C	9021749	3	2	62	1	0	0	0	0	1	0	0	0	5	1261	44	4	4301	4	A2ML1	12	9021749	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08		9021749	124830146	60	12543											
ACACB	32	broad.mit.edu	37	chr12	109698310	109698323	+	Frame_Shift_Del	DEL	TGGAGCCTACATCG	-	-																															tatgaccaggtgctgaagttTggagcctacatcgtggacgg																								rs142275188		TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr12:109698310_109698323delTGGAGCCTACATCG	uc001tob.2	+	48	6641_6654	c.6522_6535delTGGAGCCTACATCG	c.(6520-6537)TTTGGAGCCTACATCGTGfs	p.F2174fs	ACACB_uc001toc.2_Frame_Shift_Del_p.F2174fs|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Frame_Shift_Del_p.F840fs	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2174_2179	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TGCTGAAGTTTGGAGCCTACATCGTGGACGGCCT	0.542													---	---	---								-	109698323	-	-	109698310	7	5	62	1	0	1	0	1	0	0	0	0	107	1809	63	0	6708	0	ACACB	12	109698310	Frame_Shift_Del	DEL	TGGAGCCTACATCG	TCGA-CN-5365-01A-01D-1434-08	100676561	109698310	24153585	61	12544											
PXN	5829	broad.mit.edu	37	chr12	120651735	120651735	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcagccgccacacttgggTgcgaacatgtcgaagtagtc	9	7	13	12	4	0	0	0	0	0	0	2	2	0	0	2	1	3	2	2	1	3	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr12:120651735T>C	uc001txt.2	-	11	1550	c.1419A>G	c.(1417-1419)GCA>GCG	p.A473A	PXN_uc001txu.2_Silent_p.A285A|PXN_uc001txv.2_Silent_p.A354A|PXN_uc001txx.2_Silent_p.A306A|PXN_uc001txy.2_Silent_p.A439A|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	473	LIM zinc-binding 2.				cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CACACTTGGGTGCGAACATGT	0.602													3	10					0	0	0	0	C	120651735	C	C	120651735	2	2	62	1	0	0	0	0	0	0	0	1	12917	1683	59	5		5	PXN	12	120651735	Silent	SNP	T	TCGA-CN-5365-01A-01D-1434-08	10953425	120651735	13200160	62	12545											
GPR12	2835	broad.mit.edu	37	chr13	27333678	27333678	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaacaaaattggtgatgagtCcaatgccggccagcaggtct	13	8	11	9	1	1	2	0	2	1	0	2	2	2	2	3	3	3	1	3	3	4	1			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr13:27333678C>T	uc010aal.2	-	2	509	c.287G>A	c.(286-288)GGA>GAA	p.G96E	GPR12_uc010tdl.1_Intron	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	96	Helical; Name=2; (Potential).					integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		GGTGATGAGTCCAATGCCGGC	0.547													39	75					0	0	0	0	T	27333678	T	T	27333678	3	4	62	1	0	0	0	0	1	0	0	0	6673	855	30	2	721	2	GPR12	13	27333678	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08		27333678	87836200	63	12546											
PCDH9	5101	broad.mit.edu	37	chr13	67802500	67802500	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaatagtgtaaataagttCttgagctattgcggaatcca	13	14	8	6	1	2	1	0	1	2	0	3	2	3	2	1	1	2	3	1	1	7	8			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr13:67802500C>A	uc001vik.2	-	2	765	c.73G>T	c.(73-75)GAA>TAA	p.E25*	PCDH9_uc001vil.2_Nonsense_Mutation_p.E25*|PCDH9_uc010thl.1_Nonsense_Mutation_p.E25*|PCDH9_uc001vin.3_Nonsense_Mutation_p.E25*	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	25	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TAAATAAGTTCTTGAGCTATT	0.408													39	72					4.46736e-08	5.18668e-08	1	0	A	67802500	A	A	67802500	4	1	62	1	0	0	0	0	0	1	0	0	11572	922	32	2	3656	2	PCDH9	13	67802500	Nonsense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	40468822	67802500	47367378	64	12547											
TNFSF13B	10673	broad.mit.edu	37	chr13	108922758	108922758	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaataagcgtgccgttcaggGtccagaagaaacaggtatgt	14	8	12	7	2	1	2	1	0	0	2	2	2	2	2	2	2	3	2	2	2	5	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr13:108922758G>T	uc001vqr.2	+	2	677	c.410G>T	c.(409-411)GGT>GTT	p.G137V	TNFSF13B_uc010agj.2_Missense_Mutation_p.G137V	NM_006573	NP_006564	Q9Y275	TN13B_HUMAN	tumor necrosis factor superfamily, member 13b	137	Extracellular (Potential).				cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			GCCGTTCAGGGTCCAGAAGAA	0.463													18	64					1.33834e-09	1.58062e-09	1	0	T	108922758	T	T	108922758	3	4	62	1	0	0	0	0	1	0	0	0	16372	1261	44	4	416	4	TNFSF13B	13	108922758	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	41120258	108922758	6247120	65	12548											
NYNRIN	57523	broad.mit.edu	37	chr14	24884881	24884881	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgacctgtccacgttcgtctGcatccacatgtcgggctact	6	12	9	14	3	1	1	0	1	1	0	5	1	3	1	3	1	2	3	3	1	1	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr14:24884881G>A	uc001wpf.3	+	9	4244	c.3926G>A	c.(3925-3927)TGC>TAC	p.C1309Y		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1309					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						ACGTTCGTCTGCATCCACATG	0.617													129	147					0	0	0	0	A	24884881	A	A	24884881	3	1	62	1	0	0	0	0	1	0	0	0	10850	1319	46	4	3956	4	NYNRIN	14	24884881	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08		24884881	82464659	66	12549											
LRFN5	145581	broad.mit.edu	37	chr14	42357171	42357171	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctggaatacgtatgtttcAaatccagtacaatggtactt	12	13	7	9	1	1	0	1	0	0	0	2	1	2	1	2	2	3	4	2	2	7	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr14:42357171A>C	uc001wvm.2	+	3	2541	c.1343A>C	c.(1342-1344)CAA>CCA	p.Q448P	LRFN5_uc010ana.2_Missense_Mutation_p.Q448P	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	448	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CGTATGTTTCAAATCCAGTAC	0.323										HNSCC(30;0.082)			27	36					0	0	0	0	C	42357171	C	C	42357171	3	2	62	1	0	0	0	0	1	0	0	0	8991	130	5	5	1345	5	LRFN5	14	42357171	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08	17472290	42357171	64992369	67	12550											
SIX6	4990	broad.mit.edu	37	chr14	60976178	60976178	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccggggtatgtgagacccTggaagagagcggcgatgtgg	8	6	20	7	3	0	2	0	1	0	2	0	6	0	3	2	6	1	1	2	6	2	1			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr14:60976178T>C	uc001xfa.3	+	1	241	c.62T>C	c.(61-63)CTG>CCG	p.L21P		NM_007374	NP_031400	O95475	SIX6_HUMAN	SIX homeobox 6	21					organ morphogenesis|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.088)		TGTGAGACCCTGGAAGAGAGC	0.662													10	107					0	0	0	0	C	60976178	C	C	60976178	3	2	62	1	0	0	0	0	1	0	0	0	14416	1580	55	5	64	5	SIX6	14	60976178	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	18619007	60976178	46373362	68	12551											
AKAP5	9495	broad.mit.edu	37	chr14	64935861	64935861	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accccagcaagcaagcccacTtgaaacttcagaaacagacc	16	4	6	15	0	1	3	1	1	0	2	1	3	1	3	4	0	5	2	4	0	4	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr14:64935861T>A	uc001xhd.3	+	2	1127	c.749T>A	c.(748-750)CTT>CAT	p.L250H	ZBTB25_uc001xhc.2_Intron	NM_004857	NP_004848	P24588	AKAP5_HUMAN	A-kinase anchor protein 5	250					energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding				0				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		GCAAGCCCACTTGAAACTTCA	0.418													135	93					0	0	0	0	A	64935861	A	A	64935861	3	1	62	1	0	0	0	0	1	0	0	0	454	1609	56	5	751	5	AKAP5	14	64935861	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	3959683	64935861	42413679	69	12552											
AHNAK2	113146	broad.mit.edu	37	chr14	105412488	105412488	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctgagacacctccacgtcGggggccgtcacgtccgtctt	5	8	13	15	5	2	1	1	1	1	1	5	2	4	1	4	3	0	1	4	3	0	1			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr14:105412488G>A	uc010axc.1	-	7	9420	c.9300C>T	c.(9298-9300)CCC>CCT	p.P3100P	AHNAK2_uc001ypx.2_Silent_p.P3000P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3100						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTCCACGTCGGGGGCCGTCA	0.632													9	292					0	0	0	0	A	105412488	A	A	105412488	2	1	62	1	0	0	0	0	0	0	0	1	415	1103	39	1		1	AHNAK2	14	105412488	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08	40476627	105412488	1937052	70	12553											
RASGRP1	10125	broad.mit.edu	37	chr15	38786881	38786881	+	Frame_Shift_Del	DEL	C	-	-																															aaatcttctgtgaggacactCccatcagcatgatggtccga																										TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr15:38786881delC	uc001zke.3	-	16	2139	c.1961delG	c.(1960-1962)GGAfs	p.G654fs	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Intron|RASGRP1_uc010bbg.2_Intron|RASGRP1_uc001zkd.3_Frame_Shift_Del_p.G619fs	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	654					cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TGAGGACACTCCCATCAGCAT	0.527													---	---	---								-	38786881	-	-	38786881	7	5	62	1	0	1	0	1	0	0	0	0	13139	855	30	0	440	0	RASGRP1	15	38786881	Frame_Shift_Del	DEL	C	TCGA-CN-5365-01A-01D-1434-08		38786881	63744511	71	12554											
TRIM69	140691	broad.mit.edu	37	chr15	45047248	45047248	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attggttccgagacccactgAtgctaagctgtggccacaac	10	9	10	12	1	0	2	0	1	0	1	1	3	1	2	3	2	3	3	3	2	2	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr15:45047248A>G	uc001zuf.2	+	3	1052	c.157A>G	c.(157-159)ATG>GTG	p.M53V	TRIM69_uc001zui.1_Intron|TRIM69_uc010bdy.1_Intron|TRIM69_uc001zug.1_Missense_Mutation_p.M53V|TRIM69_uc001zuh.1_Intron	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	53	Necessary for nuclear localization (By similarity).|RING-type.				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		AGACCCACTGATGCTAAGCTG	0.458													18	151					0	0	0	0	G	45047248	G	G	45047248	3	3	62	1	0	0	0	0	1	0	0	0	16609	333	12	5	163	5	TRIM69	15	45047248	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08	6260367	45047248	57484144	72	12555											
SEMA6D	80031	broad.mit.edu	37	chr15	48062786	48062786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgctgcttttgttttggggGcattcattgcaggtgtggca	4	17	14	6	0	1	0	1	0	0	0	1	0	1	0	0	4	3	6	0	4	0	7			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr15:48062786G>A	uc010bek.2	+	19	2386	c.2026G>A	c.(2026-2028)GCA>ACA	p.A676T	SEMA6D_uc001zvw.2_Missense_Mutation_p.A614T|SEMA6D_uc001zvy.2_Missense_Mutation_p.A676T|SEMA6D_uc001zvz.2_Missense_Mutation_p.A620T|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Missense_Mutation_p.A614T|SEMA6D_uc001zwc.2_Missense_Mutation_p.A601T	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	676	Helical; (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TGTTTTGGGGGCATTCATTGC	0.468													5	211					0	0	0	0	A	48062786	A	A	48062786	3	1	62	1	0	0	0	0	1	0	0	0	14107	1203	42	4	2139	4	SEMA6D	15	48062786	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	3015538	48062786	54468606	73	12556											
CDR2	1039	broad.mit.edu	37	chr16	22361124	22361124	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgttcataaacctttgcaTgttgttcgttcatctgccgt	7	18	7	9	2	3	0	2	0	1	0	4	0	3	0	2	0	3	5	2	0	2	7			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr16:22361124T>A	uc002dkn.2	-	3	547	c.239A>T	c.(238-240)CAT>CTT	p.H80L		NM_001802	NP_001793	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2	80	Potential.					nucleus	protein binding			skin(1)	1				GBM - Glioblastoma multiforme(48;0.0188)		AACCTTTGCATGTTGTTCGTT	0.428													63	148					0	0	0	0	A	22361124	A	A	22361124	3	1	62	1	0	0	0	0	1	0	0	0	3187	1464	51	5	1137	5	CDR2	16	22361124	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08		22361124	67993629	74	12557											
VPS35	55737	broad.mit.edu	37	chr16	46717472	46717472	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacagcctgtatggcttcaTccaagagcttttcctgctca	8	13	7	13	0	3	1	3	0	0	1	5	1	5	1	3	1	3	4	3	1	2	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr16:46717472T>C	uc002eef.3	-	2	149	c.50A>G	c.(49-51)GAT>GGT	p.D17G	VPS35_uc002eee.2_5'UTR	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	17					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TATGGCTTCATCCAAGAGCTT	0.458													20	78					0	0	0	0	C	46717472	C	C	46717472	3	2	62	1	0	0	0	0	1	0	0	0	17271	1435	50	5	2404	5	VPS35	16	46717472	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	24356348	46717472	43637281	75	12558											
RBL2	5934	broad.mit.edu	37	chr16	53515593	53515593	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttaaacagatggatgctcCtccactctctccctatccat	9	14	4	14	0	1	1	0	0	1	1	6	2	5	2	4	1	2	1	4	1	3	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr16:53515593C>T	uc002ehi.3	+	21	3213	c.3095C>T	c.(3094-3096)CCT>CTT	p.P1032L	RBL2_uc002ehj.2_Missense_Mutation_p.P742L|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1032					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						ATGGATGCTCCTCCACTCTCT	0.313													4	37					0	0	0	0	T	53515593	T	T	53515593	3	4	62	1	0	0	0	0	1	0	0	0	13175	681	24	4	3177	4	RBL2	16	53515593	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	6798121	53515593	36839160	76	12559											
CRK	1398	broad.mit.edu	37	chr17	1340132	1340132	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggtctatacttctcgaCgtaagggactggaatcatcc	10	10	11	10	2	3	0	1	0	2	0	5	3	4	2	1	4	1	2	1	4	4	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr17:1340132C>T	uc002fsl.2	-	2	692	c.559G>A	c.(559-561)GTC>ATC	p.V187I	CRK_uc002fsm.2_Missense_Mutation_p.V187I	NM_016823	NP_058431	P46108	CRK_HUMAN	v-crk sarcoma virus CT10 oncogene homolog	187	SH3 1.				actin cytoskeleton organization|activation of MAPKK activity|blood coagulation|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of transcription from RNA polymerase II promoter	cytosol|endosome|nucleus|plasma membrane	protein binding|SH2 domain binding			lung(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (25;0.083)		TACTTCTCGACGTAAGGGACT	0.577													25	128					0	0	0	0	T	1340132	T	T	1340132	3	4	62	1	0	0	0	0	1	0	0	0	3899	536	19	1	363	1	CRK	17	1340132	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08		1340132	79855078	77	12560											
TP53	7157	broad.mit.edu	37	chr17	7578271	7578271	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccttccactcggataagaTgctgaggaggggccagacct	9	9	12	11	1	0	3	0	1	0	2	3	5	2	5	4	4	1	1	4	4	1	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr17:7578271T>A	uc002gim.2	-	6	772	c.578A>T	c.(577-579)CAT>CTT	p.H193L	TP53_uc002gig.1_Missense_Mutation_p.H193L|TP53_uc002gih.2_Missense_Mutation_p.H193L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H61L|TP53_uc010cng.1_Missense_Mutation_p.H61L|TP53_uc002gii.1_Missense_Mutation_p.H61L|TP53_uc010cnh.1_Missense_Mutation_p.H193L|TP53_uc010cni.1_Missense_Mutation_p.H193L|TP53_uc002gij.2_Missense_Mutation_p.H193L|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100L|TP53_uc002gio.2_Missense_Mutation_p.H61L|TP53_uc010vug.1_Missense_Mutation_p.H154L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	193	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> D (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(67)|p.H193L(31)|p.H193Y(26)|p.H193P(12)|p.0?(7)|p.H193D(7)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.H193H(2)|p.P191fs*53(2)|p.K164_P219del(1)|p.P191fs*15(1)|p.P191fs*6(1)|p.H100L(1)|p.H61L(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			44	30					0	0	0	0	A	7578271	A	A	7578271	3	1	62	1	0	0	0	0	1	0	0	0	16448	1464	51	5	716	5	TP53	17	7578271	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	6238139	7578271	73616939	78	12561											
SLFN5	162394	broad.mit.edu	37	chr17	33592377	33592377	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acagagtggtccgcaatgcaGgtccaatagctaattaccta	13	9	9	10	1	0	1	0	0	0	1	2	1	2	1	3	2	3	3	3	2	6	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr17:33592377G>T	uc002hjf.3	+	5	2263	c.2146G>T	c.(2146-2148)GGT>TGT	p.G716C	SLFN5_uc010wcg.1_3'UTR	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	716					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		CCGCAATGCAGGTCCAATAGC	0.507													34	91					2.08457e-15	2.48335e-15	1	0	T	33592377	T	T	33592377	3	4	62	1	0	0	0	0	1	0	0	0	14801	1000	35	4	2160	4	SLFN5	17	33592377	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	26014106	33592377	47602833	79	12562											
SLFN11	91607	broad.mit.edu	37	chr17	33679727	33679727	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaggtcattatttgctccAcagtcaagtatttcttaatt	11	16	5	9	0	3	0	2	0	1	0	4	0	4	0	1	1	1	2	1	1	4	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr17:33679727A>G	uc010ctp.2	-	7	2796	c.2354T>C	c.(2353-2355)GTG>GCG	p.V785A	SLFN11_uc010ctq.2_Missense_Mutation_p.V785A|SLFN11_uc002hjh.3_Missense_Mutation_p.V785A|SLFN11_uc002hjg.3_Missense_Mutation_p.V785A|SLFN11_uc010ctr.2_Missense_Mutation_p.V785A	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	785						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TATTTGCTCCACAGTCAAGTA	0.488													13	46					0	0	0	0	G	33679727	G	G	33679727	3	3	62	1	0	0	0	0	1	0	0	0	14797	159	6	5	355	5	SLFN11	17	33679727	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08	87350	33679727	47515483	80	12563											
C17orf98	388381	broad.mit.edu	37	chr17	36997562	36997562	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctagagcgcccataagcGcgggcagcggtgctcacagc	8	4	15	14	4	1	1	1	0	0	1	1	1	1	1	2	3	5	2	2	3	2	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr17:36997562G>A	uc002hqv.2	-	1	81	c.81C>T	c.(79-81)CGC>CGT	p.R27R		NM_001080465	NP_001073934	A8MV24	CQ098_HUMAN	hypothetical protein LOC388381	27											0						GCCCATAAGCGCGGGCAGCGG	0.637													4	85					0	0	0	0	A	36997562	A	A	36997562	2	1	62	1	0	0	0	0	0	0	0	1	1902	1074	38	1		1	C17orf98	17	36997562	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08	3317835	36997562	44197648	81	12564											
IKZF3	22806	broad.mit.edu	37	chr17	37922445	37922445	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccactattgttgggagagagGcctctctcagaaggcacgct	9	9	12	11	1	2	2	1	0	1	2	3	4	2	3	2	3	0	3	2	3	2	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr17:37922445G>A	uc002hsu.2	-	8	1190	c.1128C>T	c.(1126-1128)GGC>GGT	p.G376G	IKZF3_uc002htd.2_Silent_p.G342G|IKZF3_uc010cwd.2_Silent_p.G233G|IKZF3_uc002hsv.2_Silent_p.G303G|IKZF3_uc010cwe.2_Silent_p.G242G|IKZF3_uc010cwf.2_Silent_p.G194G|IKZF3_uc010cwg.2_Silent_p.G155G|IKZF3_uc002hsw.2_Silent_p.G337G|IKZF3_uc002hsx.2_Silent_p.G320G|IKZF3_uc002hsy.2_Silent_p.G337G|IKZF3_uc002hsz.2_Silent_p.G281G|IKZF3_uc002hta.2_Silent_p.G298G|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Silent_p.G289G|IKZF3_uc002htc.2_Silent_p.G129G|IKZF3_uc010wel.1_Silent_p.G129G	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	376					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TGGGAGAGAGGCCTCTCTCAG	0.532													15	199					0	0	0	0	A	37922445	A	A	37922445	2	1	62	1	0	0	0	0	0	0	0	1	7655	1190	42	4		4	IKZF3	17	37922445	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08	924883	37922445	43272765	82	12565											
SUPT4H1	6827	broad.mit.edu	37	chr17	56429452	56429452	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accagcgaacacagcaaacaGgcccgcagatgccgcaggtc	13	2	11	15	3	0	1	0	0	0	1	1	2	0	1	3	2	5	3	3	2	2	0			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr17:56429452G>A	uc002iwe.1	-	1	112	c.45C>T	c.(43-45)GCC>GCT	p.A15A	uc010dct.1_RNA|uc010dcu.1_RNA|uc002ivz.2_RNA|uc010dcv.1_RNA|uc002iwa.2_RNA|uc002iwb.2_RNA|uc002iwc.2_RNA|SUPT4H1_uc002iwd.1_RNA	NM_003168	NP_003159	P63272	SPT4H_HUMAN	suppressor of Ty 4 homolog 1	15	Interaction with SUPT5H.				chromatin remodeling|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACAGCAAACAGGCCCGCAGAT	0.632													15	78					0	0	0	0	A	56429452	A	A	56429452	2	1	62	1	0	0	0	0	0	0	0	1	15464	987	35	4		4	SUPT4H1	17	56429452	Silent	SNP	G	TCGA-CN-5365-01A-01D-1434-08	18507007	56429452	24765758	83	12566											
TLK2	11011	broad.mit.edu	37	chr17	60657496	60657496	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagatcatccaacgctaaaTgacagatatttgttgttaca	16	12	6	7	1	1	3	1	1	0	2	2	3	2	3	1	0	2	3	1	0	6	5			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr17:60657496T>C	uc010ddp.2	+	16	1645	c.1377T>C	c.(1375-1377)AAT>AAC	p.N459N	TLK2_uc002izx.3_Silent_p.N285N|TLK2_uc002izz.3_Silent_p.N437N|TLK2_uc002jaa.3_Silent_p.N405N|TLK2_uc010wpd.1_Silent_p.N405N	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	459					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						CAACGCTAAATGACAGATATT	0.383													16	63					0	0	0	0	C	60657496	C	C	60657496	2	2	62	1	0	0	0	0	0	0	0	1	16010	1461	51	5		5	TLK2	17	60657496	Silent	SNP	T	TCGA-CN-5365-01A-01D-1434-08	4228044	60657496	20537714	84	12567											
RAB37	326624	broad.mit.edu	37	chr17	72741163	72741163	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggagtacggtgttccctTcctggagaccagcgccaaga	9	7	13	12	2	0	2	0	0	0	2	2	4	2	3	4	3	2	3	4	3	2	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr17:72741163T>C	uc002jlk.2	+	8	562	c.506T>C	c.(505-507)TTC>TCC	p.F169S	RAB37_uc002jlc.2_3'UTR|RAB37_uc010dfu.2_Missense_Mutation_p.F162S|RAB37_uc002jld.2_Missense_Mutation_p.F162S|RAB37_uc010wrb.1_Missense_Mutation_p.F137S|RAB37_uc010wrc.1_Missense_Mutation_p.F174S|RAB37_uc010wrd.1_Missense_Mutation_p.F137S|RAB37_uc010wre.1_Missense_Mutation_p.F132S|RAB37_uc002jll.3_RNA	NM_001006638	NP_001006639	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family isoform 2	169					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			ovary(1)	1						GGTGTTCCCTTCCTGGAGACC	0.627											OREG0024716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	72					0	0	0	0	C	72741163	C	C	72741163	3	2	62	1	0	0	0	0	1	0	0	0	12992	1783	62	5	839	5	RAB37	17	72741163	Missense_Mutation	SNP	T	TCGA-CN-5365-01A-01D-1434-08	12083667	72741163	8454047	85	12568											
TJP3	27134	broad.mit.edu	37	chr19	3738943	3738943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggtgactccttctacatccGcactcactttgagctggagc	7	11	10	13	1	2	2	1	2	1	0	4	3	4	3	2	2	3	2	2	2	1	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr19:3738943G>A	uc010xhv.1	+	12	1541	c.1541G>A	c.(1540-1542)CGC>CAC	p.R514H	TJP3_uc010xhs.1_Missense_Mutation_p.R481H|TJP3_uc010xht.1_Missense_Mutation_p.R445H|TJP3_uc010xhu.1_Missense_Mutation_p.R490H|TJP3_uc010xhw.1_Missense_Mutation_p.R500H	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	495	SH3.					tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTACATCCGCACTCACTTT	0.647													4	97					0	0	0	0	A	3738943	A	A	3738943	3	1	62	1	0	0	0	0	1	0	0	0	15997	1087	38	1	1587	1	TJP3	19	3738943	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08		3738943	55390040	86	12569											
FCER2	2208	broad.mit.edu	37	chr19	7755094	7755094	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gataaactcccccttcaggtCcaagttccgaaggccaatcc	11	8	7	15	1	1	0	1	0	0	0	5	2	5	0	6	2	1	1	6	2	5	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr19:7755094C>A	uc002mhn.2	-	10	863	c.679G>T	c.(679-681)GAC>TAC	p.D227Y	FCER2_uc010xjs.1_Missense_Mutation_p.D149Y|FCER2_uc010xjt.1_Missense_Mutation_p.D149Y|FCER2_uc002mhm.2_Missense_Mutation_p.D227Y	NM_002002	NP_001993	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor	227	C-type lectin.|Extracellular (Potential).				positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding				0						CCCTTCAGGTCCAAGTTCCGA	0.617													9	59					0.00448238	0.00468768	1	0	A	7755094	A	A	7755094	3	1	62	1	0	0	0	0	1	0	0	0	5808	855	30	2	294	2	FCER2	19	7755094	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	4016151	7755094	51373889	87	12570											
MUC16	94025	broad.mit.edu	37	chr19	9060492	9060492	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcttgttatctcagaggaaGcaggtatggttgtagaaaca	12	13	11	5	0	2	2	1	0	2	2	3	3	2	3	0	3	2	5	0	3	5	6			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr19:9060492G>A	uc002mkp.2	-	3	27158	c.26954C>T	c.(26953-26955)GCT>GTT	p.A8985V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8987	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTCAGAGGAAGCAGGTATGGT	0.498													29	183					0	0	0	0	A	9060492	A	A	9060492	3	1	62	1	0	0	0	0	1	0	0	0	10026	971	34	4	16897	4	MUC16	19	9060492	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	1305398	9060492	50068491	88	12571											
SIGLEC5	8778	broad.mit.edu	37	chr19	52129338	52129338	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atccattttctctggtctccCagctgcttgcttcctgcggg	3	15	9	14	1	2	0	0	0	2	0	6	0	4	0	3	2	4	3	3	2	0	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr19:52129338C>G	uc002pxe.2	-	8	1550	c.1411G>C	c.(1411-1413)GGG>CGG	p.G471R		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	471	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TCTGGTCTCCCAGCTGCTTGC	0.547													11	120					0	0	0	0	G	52129338	G	G	52129338	3	3	62	1	0	0	0	0	1	0	0	0	14376	594	21	4	252	4	SIGLEC5	19	52129338	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	43068846	52129338	6999645	89	12572											
ZNF845	91664	broad.mit.edu	37	chr19	53854664	53854664	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcgaaacaatataaatgtGatgtgtgtggcaaggtcttt	13	12	12	4	1	1	1	0	1	1	0	1	3	1	1	0	2	2	1	0	2	6	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr19:53854664G>A	uc010ydv.1	+	4	853	c.736G>A	c.(736-738)GAT>AAT	p.D246N	ZNF845_uc010ydw.1_Missense_Mutation_p.D246N	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	246	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATATAAATGTGATGTGTGTGG	0.368													8	75					0	0	0	0	A	53854664	A	A	53854664	3	1	62	1	0	0	0	0	1	0	0	0	18258	1290	45	2	746	2	ZNF845	19	53854664	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	1725326	53854664	5274319	90	12573											
NLRP8	126205	broad.mit.edu	37	chr19	56466469	56466469	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaagcccttgctgaaatgtCcctctctcgtaacccttccg	7	11	7	16	2	1	1	0	1	1	0	5	1	3	1	4	0	3	3	4	0	3	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr19:56466469C>A	uc002qmh.2	+	3	1116	c.1045C>A	c.(1045-1047)CCC>ACC	p.P349T	NLRP8_uc010etg.2_Missense_Mutation_p.P349T	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	349	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GCTGAAATGTCCCTCTCTCGT	0.453													13	168					0.000219431	0.000236709	1	0	A	56466469	A	A	56466469	3	1	62	1	0	0	0	0	1	0	0	0	10537	855	30	2	1055	2	NLRP8	19	56466469	Missense_Mutation	SNP	C	TCGA-CN-5365-01A-01D-1434-08	2611805	56466469	2662514	91	12574											
ZNF135	7694	broad.mit.edu	37	chr19	58579671	58579671	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acactggggaaaagccctatGagtgtcacgattgcggaaag	13	7	13	8	2	1	1	1	1	0	0	1	4	1	3	1	3	2	0	1	3	4	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr19:58579671G>C	uc010yhq.1	+	5	1951	c.1855G>C	c.(1855-1857)GAG>CAG	p.E619Q	ZNF135_uc002qre.2_Missense_Mutation_p.E607Q|ZNF135_uc002qrd.1_Intron|ZNF135_uc002qrf.2_Missense_Mutation_p.E565Q|ZNF135_uc002qrg.2_Missense_Mutation_p.E577Q|ZNF135_uc010yhr.1_Missense_Mutation_p.E428Q	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	619					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		AAAGCCCTATGAGTGTCACGA	0.557													5	167					0	0	0	0	C	58579671	C	C	58579671	3	2	62	1	0	0	0	0	1	0	0	0	17792	1291	45	2	2022	2	ZNF135	19	58579671	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	2113202	58579671	549312	92	12575											
PTPRT	11122	broad.mit.edu	37	chr20	40743873	40743873	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgcgtatgacgtattctGccaggggctctgtttcaatc	7	13	12	9	2	3	1	1	1	2	0	4	1	3	1	1	3	2	4	1	3	3	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr20:40743873G>T	uc002xkg.2	-	22	3249	c.3065C>A	c.(3064-3066)GCA>GAA	p.A1022E	PTPRT_uc010ggj.2_Missense_Mutation_p.A1041E|PTPRT_uc010ggi.2_Missense_Mutation_p.A225E	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1022	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GACGTATTCTGCCAGGGGCTC	0.488													30	143					4.23469e-30	5.13409e-30	1	0	T	40743873	T	T	40743873	3	4	62	1	0	0	0	0	1	0	0	0	12877	1319	46	4	1300	4	PTPRT	20	40743873	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08		40743873	22281647	93	12576											
SAMD10	140700	broad.mit.edu	37	chr20	62608688	62608706	+	Frame_Shift_Del	DEL	AGTGGCAGGGGATGCTCTC	-	-																															ggtgccaggtgtccgaggcaAgtggcaggggatgctctcag																										TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr20:62608688_62608706delAGTGGCAGGGGATGCTCTC	uc002yhm.2	-	2	320_338	c.145_163delGAGAGCATCCCCTGCCACT	c.(145-165)GAGAGCATCCCCTGCCACTTGfs	p.E49fs	SAMD10_uc002yhn.2_RNA	NM_080621	NP_542188	Q9BYL1	SAM10_HUMAN	sterile alpha motif domain containing 10	49_55											0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GTCCGAGGCAAGTGGCAGGGGATGCTCTCAGCTGACACC	0.658													---	---	---								-	62608706	-	-	62608688	7	5	62	1	0	1	0	1	0	0	0	0	13880	69	3	0	461	0	SAMD10	20	62608688	Frame_Shift_Del	DEL	AGTGGCAGGGGATGCTCTC	TCGA-CN-5365-01A-01D-1434-08	21864815	62608688	416832	94	12577											
NF2	4771	broad.mit.edu	37	chr22	30057317	30057318	+	Frame_Shift_Ins	INS	-	GT	GT																															aatccgaaacatctcgtacaINSgtgacaaggaggtaggacat																										TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr22:30057317_30057318insGT	uc003age.3	+	8	1242_1243	c.799_800insGT	c.(799-801)AGTfs	p.S267fs	NF2_uc003afy.3_Frame_Shift_Ins_p.S267fs|NF2_uc003afz.3_Frame_Shift_Ins_p.S184fs|NF2_uc003agf.3_Frame_Shift_Ins_p.S267fs|NF2_uc003agb.3_Frame_Shift_Ins_p.S190fs|NF2_uc003agc.3_Frame_Shift_Ins_p.S229fs|NF2_uc003agd.3_RNA|NF2_uc003agg.3_Frame_Shift_Ins_p.S267fs|NF2_uc003aga.3_Frame_Shift_Ins_p.S225fs|NF2_uc003agh.3_Frame_Shift_Ins_p.S226fs|NF2_uc003agi.3_Frame_Shift_Ins_p.S184fs|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Frame_Shift_Ins_p.S229fs	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	267	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.L127_D382del(1)|p.N226_E270del(1)|p.?(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						CATCTCGTACAGTGACAAGGAG	0.554			D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				---	---	---								GT	30057318	GT	GT	30057317	7	5	62	1	0	1	1	0	0	0	0	0	10411	188	7	0	829	0	NF2	22	30057317	Frame_Shift_Ins	INS	-	TCGA-CN-5365-01A-01D-1434-08		30057317	21247249	95	12578											
BAIAP2L2	80115	broad.mit.edu	37	chr22	38483189	38483190	+	In_Frame_Ins	INS	-	GGTCATGGA	GGTCATGGA																															ggggacatggaggtcatggaINSggtcatgggggtcacggggg																								rs71803583		TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chr22:38483189_38483190insGGTCATGGA	uc003auw.2	-	11	1344_1345	c.1200_1201insTCCATGACC	c.(1198-1203)insTCCATGACC	p.403_404insSMT	BAIAP2L2_uc003auv.2_5'Flank	NM_025045	NP_079321	Q6UXY1	BI2L2_HUMAN	BAI1-associated protein 2-like 2	403_404					filopodium assembly|signal transduction		cytoskeletal adaptor activity|SH3 domain binding			pancreas(1)	1	Melanoma(58;0.045)					gaggtcatggaggtcatggggg	0.45													---	---	---								GGTCATGGA	38483190	GGTCATGGA	GGTCATGGA	38483189	7	5	62	1	0	1	1	0	0	0	0	0	1305	304	11	0	404	0	BAIAP2L2	22	38483189	In_Frame_Ins	INS	-	TCGA-CN-5365-01A-01D-1434-08	8425872	38483189	12821377	96	12579											
FAM47C	442444	broad.mit.edu	37	chrX	37029320	37029320	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcatggtacctcaagcctaAgttggggaaaaagctaagaa	16	7	11	7	0	1	1	1	0	0	1	1	2	1	2	2	3	4	4	2	3	7	4			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chrX:37029320A>T	uc004ddl.1	+	1	2851	c.2837A>T	c.(2836-2838)AAG>ATG	p.K946M		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	946										ovary(3)	3						CTCAAGCCTAAGTTGGGGAAA	0.453													49	50					0	0	0	0	T	37029320	T	T	37029320	3	4	62	1	0	0	0	0	1	0	0	0	5603	72	3	5	2839	5	FAM47C	23	37029320	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08		37029320	118241240	97	12580											
SYP	6855	broad.mit.edu	37	chrX	49049871	49049871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acagccccttggcccatgccGatgagctaactagccacatg	10	7	9	15	1	0	1	0	1	0	0	0	2	0	1	5	1	5	1	5	1	2	3			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chrX:49049871G>A	uc004dmz.1	-	5	489	c.473C>T	c.(472-474)TCG>TTG	p.S158L	SYP_uc011mmz.1_Missense_Mutation_p.S40L|SYP_uc004dna.1_Missense_Mutation_p.S152L	NM_003179	NP_003170	P08247	SYPH_HUMAN	synaptophysin	158	MARVEL.|Helical; (Potential).		S -> L.		regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle maturation|synaptic vesicle membrane organization	cell junction|integral to synaptic vesicle membrane|synaptosome	calcium ion binding|cholesterol binding|transporter activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(315;0.00016)				GGCCCATGCCGATGAGCTAAC	0.562													11	10					0	0	0	0	A	49049871	A	A	49049871	3	1	62	1	0	0	0	0	1	0	0	0	15527	1059	37	1	476	1	SYP	23	49049871	Missense_Mutation	SNP	G	TCGA-CN-5365-01A-01D-1434-08	12020551	49049871	106220689	98	12581											
RLIM	51132	broad.mit.edu	37	chrX	73836527	73836528	+	5'Flank	INS	-	T	T																															cttccttccttctttctttcINSttttttttttttgatggagt																										TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chrX:73836527_73836528insT	uc004ebu.2	-						RLIM_uc004ebw.2_5'Flank	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting						random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						ttctttctttcttttttttttt	0													---	---	---								T	73836528	T	T	73836527	6	5	62	0	1	1	1	0	0	0	0	0	13455	928	32	0		0	RLIM	23	73836527	5'Flank	INS	-	TCGA-CN-5365-01A-01D-1434-08	24786656	73836527	81434033	99	12582											
ODZ1	10178	broad.mit.edu	37	chrX	123587207	123587207	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagtgatgtccattcctgAgtcacagctcagtggttgtg	7	13	12	9	0	2	3	2	3	0	0	4	3	4	3	2	1	1	2	2	1	0	2			TCGA-CN-5365-01A-01D-1434-08	TCGA-CN-5365-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	a419a54c-58b4-4682-aaca-ed85697dd2a0	59b70846-64f0-489e-8ea5-84a347aedeb8	g.chrX:123587207A>G	uc004euj.2	-	22	4127	c.4063T>C	c.(4063-4065)TCA>CCA	p.S1355P	ODZ1_uc011muj.1_Missense_Mutation_p.S1361P|ODZ1_uc010nqy.2_Missense_Mutation_p.S1362P	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1355	NHL 3.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCCATTCCTGAGTCACAGCTC	0.413													4	98					0	0	0	0	G	123587207	G	G	123587207	3	3	62	1	0	0	0	0	1	0	0	0	10888	304	11	5	4154	5	ODZ1	23	123587207	Missense_Mutation	SNP	A	TCGA-CN-5365-01A-01D-1434-08	49750680	123587207	31683353	100	12583											
KIAA2013	90231	broad.mit.edu	37	chr1	11985515	11985515	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttggcggccaccaccaccagGtgcaccaacccagtgggcgt	8	5	12	16	2	0	0	0	0	0	0	0	0	0	0	6	4	2	1	6	4	1	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:11985515G>A	uc001atk.2	-	1	974	c.780C>T	c.(778-780)CAC>CAT	p.H260H	KIAA2013_uc001atl.1_Silent_p.H260H	NM_138346	NP_612355	Q8IYS2	K2013_HUMAN	hypothetical protein LOC90231 precursor	260	Extracellular (Potential).					integral to membrane				ovary(1)	1	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCACCACCAGGTGCACCAACC	0.647													10	41					0	0	0	0	A	11985515	A	A	11985515	2	1	63	1	0	0	0	0	0	0	0	1	8306	1252	44	4		4	KIAA2013	1	11985515	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08		11985515	237265106	1	12584											
LDLRAD2	401944	broad.mit.edu	37	chr1	22141157	22141157	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctacctgcagttctacgagGgcccgccgggggcgccccgg	4	5	15	17	5	1	0	0	0	1	0	1	1	1	0	6	4	3	2	6	4	2	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:22141157G>A	uc001bfg.1	+	2	539	c.352G>A	c.(352-354)GGC>AGC	p.G118S		NM_001013693	NP_001013715	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain	118	Extracellular (Potential).					integral to membrane	receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		GTTCTACGAgggcccgccggg	0.622													4	16					0	0	0	0	A	22141157	A	A	22141157	3	1	63	1	0	0	0	0	1	0	0	0	8746	1232	43	4	358	4	LDLRAD2	1	22141157	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	10155642	22141157	227109464	2	12585											
SFRS4	6429	broad.mit.edu	37	chr1	29475301	29475301	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcactcttgctgcggctgCgactgcgactgcggctctcc	3	11	11	16	4	3	0	1	0	3	0	5	2	3	0	1	2	5	3	1	2	0	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:29475301C>T	uc001bro.2	-	6	1479	c.1106G>A	c.(1105-1107)CGC>CAC	p.R369H	SFRS4_uc010ofy.1_3'UTR	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	369	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		gctgcggctgcgactgcgact	0.09													5	41					0	0	0	0	T	29475301	T	T	29475301	3	4	63	1	0	0	0	0	1	0	0	0	14244	768	27	1	382	1	SFRS4	1	29475301	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	7334144	29475301	219775320	3	12586											
MFSD2A	84879	broad.mit.edu	37	chr1	40434298	40434298	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacgtgtcaagtttacactGaacatgctcgtgaccatggc	11	10	10	10	2	1	2	1	2	0	0	2	3	1	2	1	1	4	2	1	1	4	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:40434298G>A	uc001cev.2	+	13	1630	c.1449G>A	c.(1447-1449)CTG>CTA	p.L483L	MFSD2A_uc010ojb.1_Silent_p.L431L|MFSD2A_uc001ceu.2_Silent_p.L470L|MFSD2A_uc010ojc.1_Silent_p.L314L|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cex.2_Silent_p.L134L	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	483	Helical; (Potential).				transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						AGTTTACACTGAACATGCTCG	0.567													46	161					0	0	0	0	A	40434298	A	A	40434298	2	1	63	1	0	0	0	0	0	0	0	1	9583	1277	45	2		2	MFSD2A	1	40434298	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	10958997	40434298	208816323	4	12587											
PIGK	10026	broad.mit.edu	37	chr1	77588033	77588033	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagtttctcatccatctggTcttccttatagctggaaaag	9	16	7	9	0	3	0	1	0	3	0	6	1	5	1	2	2	1	2	2	2	5	5			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:77588033T>C	uc001dhk.2	-	10	1043	c.998A>G	c.(997-999)GAC>GGC	p.D333G	PIGK_uc010orj.1_Missense_Mutation_p.D257G|PIGK_uc009wbx.2_Missense_Mutation_p.D239G	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	333	Lumenal (Potential).			Missing: Loss of activity.	attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						ATCCATCTGGTCTTCCTTATA	0.299													23	86					0	0	0	0	C	77588033	C	C	77588033	3	2	63	1	0	0	0	0	1	0	0	0	11945	1667	58	5	197	5	PIGK	1	77588033	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	37153735	77588033	171662588	5	12588											
GTF2B	2959	broad.mit.edu	37	chr1	89325684	89325684	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atacttgcttgaataaattaTttgttcgatccttcaaagca	13	16	5	7	1	1	1	1	1	0	0	3	2	2	1	1	0	3	3	1	0	6	8			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:89325684T>C	uc001dmo.3	-	5	535	c.416A>G	c.(415-417)AAT>AGT	p.N139S		NM_001514	NP_001505	Q00403	TF2B_HUMAN	general transcription factor IIB	139	1.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	thyroid hormone receptor binding|translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0131)|Epithelial(280;0.0255)		GAATAAATTATTTGTTCGATC	0.343													26	184					0	0	0	0	C	89325684	C	C	89325684	3	2	63	1	0	0	0	0	1	0	0	0	6894	1493	52	5	546	5	GTF2B	1	89325684	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	11737651	89325684	159924937	6	12589											
BCAR3	8412	broad.mit.edu	37	chr1	94033309	94033310	+	Frame_Shift_Ins	INS	-	CA	CA																															tgctcacctctgccttcatgINScaggagtttgctgaagggct																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:94033309_94033310insCA	uc001dpz.2	-	10	2348_2349	c.2073_2074insTG	c.(2071-2076)CTGCATfs	p.L691fs	BCAR3_uc001dqa.2_Frame_Shift_Ins_p.L691fs|BCAR3_uc001dqb.2_Frame_Shift_Ins_p.L691fs|BCAR3_uc001dpx.3_Frame_Shift_Ins_p.L367fs|BCAR3_uc001dpy.2_Frame_Shift_Ins_p.L600fs	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	691_692	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CTGCCTTCATGCAGGAGTTTGC	0.535													---	---	---								CA	94033310	CA	CA	94033309	7	5	63	1	0	1	1	0	0	0	0	0	1351	1319	46	0	415	0	BCAR3	1	94033309	Frame_Shift_Ins	INS	-	TCGA-CN-5366-01A-01D-1434-08	4707625	94033309	155217312	7	12590											
SLC6A17	388662	broad.mit.edu	37	chr1	110709633	110709633	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggccgacctgctggccctcGaggagcctgtggactataag	7	8	14	12	2	0	0	0	0	0	0	1	4	0	2	4	4	2	1	4	4	2	2	rs142242142		TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:110709633G>A	uc009wfq.2	+	2	543	c.82G>A	c.(82-84)GAG>AAG	p.E28K		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	28	Cytoplasmic (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		GCTGGCCCTCGAGGAGCCTGT	0.617													6	22					0	0	0	0	A	110709633	A	A	110709633	3	1	63	1	0	0	0	0	1	0	0	0	14744	1059	37	1	84	1	SLC6A17	1	110709633	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	16676324	110709633	138540988	8	12591											
SYT6	148281	broad.mit.edu	37	chr1	114680442	114680442	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtcaaaagccttcaggataCgcacaatcagggtctcggtc	11	8	11	11	2	4	0	3	0	1	0	6	1	4	1	1	4	2	1	1	4	4	2	rs139165674	byFrequency	TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:114680442C>T	uc001eev.2	-	3	741	c.491G>A	c.(490-492)CGT>CAT	p.R164H		NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	249	Cytoplasmic (Potential).|C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCAGGATACGCACAATCAG	0.542													14	123					0	0	0	0	T	114680442	T	T	114680442	3	4	63	1	0	0	0	0	1	0	0	0	15544	536	19	1	806	1	SYT6	1	114680442	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	3970809	114680442	134570179	9	12592											
BCL9	607	broad.mit.edu	37	chr1	147096054	147096054	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagttcagcagatgcagcacTttgcaagcctggaggccccg	10	7	12	12	1	1	1	1	0	0	1	1	2	1	2	3	2	5	5	3	2	2	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:147096054T>C	uc001epq.2	+	10	4315	c.3575T>C	c.(3574-3576)CTT>CCT	p.L1192P	BCL9_uc010ozr.1_Missense_Mutation_p.L1106P	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1192	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					GATGCAGCACTTTGCAAGCCT	0.627			T	IGH@|IGL@	B-ALL								9	112					0	0	0	0	C	147096054	C	C	147096054	3	2	63	1	0	0	0	0	1	0	0	0	1383	1609	56	5	3601	5	BCL9	1	147096054	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	32415612	147096054	102154567	10	12593											
ATP8B2	57198	broad.mit.edu	37	chr1	154303598	154303598	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgtcctcaccatcacagcTgttaaagatgccactgatga	11	11	7	12	0	2	3	2	2	0	1	3	3	3	3	3	0	2	2	3	0	2	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:154303598T>A	uc001fey.1	+	4	525	c.336T>A	c.(334-336)GCT>GCA	p.A112A	ATP8B2_uc001few.2_Silent_p.A93A|ATP8B2_uc001fex.2_Silent_p.A126A	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	112	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCATCACAGCTGTTAAAGATG	0.353													32	93					0	0	0	0	A	154303598	A	A	154303598	2	1	63	1	0	0	0	0	0	0	0	1	1197	1567	55	5		5	ATP8B2	1	154303598	Silent	SNP	T	TCGA-CN-5366-01A-01D-1434-08	7207544	154303598	94947023	11	12594											
DNM3	26052	broad.mit.edu	37	chr1	171956930	171956930	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatacccattaatttacgaGtctattccccacacggtaag	12	11	5	13	2	1	0	0	0	1	0	2	1	2	0	4	1	2	1	4	1	5	7			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:171956930G>T	uc001gie.2	+	3	546	c.370G>T	c.(370-372)GTC>TTC	p.V124F	DNM3_uc001gid.3_Missense_Mutation_p.V124F|DNM3_uc009wwb.2_Missense_Mutation_p.V124F|DNM3_uc001gif.2_Missense_Mutation_p.V124F	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	124					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						TAATTTACGAGTCTATTCCCC	0.333													14	188					6.31663e-08	6.72562e-08	1	0	T	171956930	T	T	171956930	3	4	63	1	0	0	0	0	1	0	0	0	4695	1029	36	4	380	4	DNM3	1	171956930	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	17653332	171956930	77293691	12	12595											
USH2A	7399	broad.mit.edu	37	chr1	216496972	216496972	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatagaagttattgtatccaGgacgataatttggtccaggt	12	14	10	5	1	0	1	0	0	0	1	2	3	2	2	2	3	0	2	2	3	6	7			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:216496972G>A	uc001hku.1	-	8	1781	c.1394C>T	c.(1393-1395)CCT>CTT	p.P465L	USH2A_uc001hkv.2_Missense_Mutation_p.P465L	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	465	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTGTATCCAGGACGATAATT	0.378										HNSCC(13;0.011)			16	172					0	0	0	0	A	216496972	A	A	216496972	3	1	63	1	0	0	0	0	1	0	0	0	17104	1000	35	4	14488	4	USH2A	1	216496972	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	44540042	216496972	32753649	13	12596											
TRIM58	25893	broad.mit.edu	37	chr1	248028043	248028043	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agaggcagcgcttcagattgGagtttgagaagcatcgtggc	10	9	15	7	2	1	3	1	1	0	3	2	5	1	4	0	3	2	4	0	3	1	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr1:248028043G>C	uc001ido.2	+	3	601	c.553G>C	c.(553-555)GAG>CAG	p.E185Q		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	185						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTTCAGATTGGAGTTTGAGAA	0.602													13	66					0	0	0	0	C	248028043	C	C	248028043	3	2	63	1	0	0	0	0	1	0	0	0	16598	1175	41	2	563	2	TRIM58	1	248028043	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	31531071	248028043	1222578	14	12597											
GREB1	9687	broad.mit.edu	37	chr2	11780421	11780421	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgttgtccacgcaggtgcGacgttgtgtgtcatctgtca	5	12	13	11	4	3	0	2	0	1	0	4	1	4	0	2	1	1	3	2	1	0	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:11780421G>A	uc002rbk.1	+	33	5991	c.5691G>A	c.(5689-5691)GCG>GCA	p.A1897A	GREB1_uc002rbp.1_Silent_p.A895A	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1897						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ACGCAGGTGCGACGTTGTGTG	0.602													20	58					0	0	0	0	A	11780421	A	A	11780421	2	1	63	1	0	0	0	0	0	0	0	1	6799	1045	37	1		1	GREB1	2	11780421	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08		11780421	231418952	15	12598											
WDR35	57539	broad.mit.edu	37	chr2	20141576	20141576	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaatcctcaaaattacaaaTatatccagaggtctgaatgg	17	11	6	7	0	2	2	1	1	1	1	4	2	4	2	2	2	1	0	2	2	9	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:20141576T>C	uc002rdi.2	-	18	2011	c.1903A>G	c.(1903-1905)ATT>GTT	p.I635V	WDR35_uc002rdj.2_Missense_Mutation_p.I624V|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Missense_Mutation_p.I200V|WDR35_uc002rdk.3_Missense_Mutation_p.I200V	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	635										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAATTACAAATATATCCAGAG	0.264													4	19					0	0	0	0	C	20141576	C	C	20141576	3	2	63	1	0	0	0	0	1	0	0	0	17357	1406	49	5	1686	5	WDR35	2	20141576	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	8361155	20141576	223057797	16	12599											
KCNG3	170850	broad.mit.edu	37	chr2	42671599	42671599	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagagatgtaatacggcgtGattgccagtaaatcaatgat	15	10	10	6	2	1	3	1	2	0	1	1	4	1	3	1	1	2	2	1	1	5	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:42671599G>C	uc002rsn.2	-	2	1382	c.786C>G	c.(784-786)ATC>ATG	p.I262M	KCNG3_uc002rsm.2_Missense_Mutation_p.I251M	NM_133329	NP_579875	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G,	262	Helical; Name=Segment S3; (Potential).					endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)	1						AATACGGCGTGATTGCCAGTA	0.463													38	107					0	0	0	0	C	42671599	C	C	42671599	3	2	63	1	0	0	0	0	1	0	0	0	8068	1280	45	2	528	2	KCNG3	2	42671599	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	22530023	42671599	200527774	17	12600											
LRP1B	53353	broad.mit.edu	37	chr2	141459289	141459289	+	Splice_Site	DEL	C	-	-																															tattctttcaagagtgctgaCctttctctcttactcggtta																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:141459289delC	uc002tvj.1	-	40	7399	c.6427_splice	c.e40+1	p.G2143_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGAGTGCTGACCTTTCTCTCT	0.348										TSP Lung(27;0.18)			---	---	---								-	141459289	-	-	141459289	8	5	63	1	0	1	0	1	0	0	1	0	9005	521	18	0	7579	0	LRP1B	2	141459289	Splice_Site	DEL	C	TCGA-CN-5366-01A-01D-1434-08	98787690	141459289	101740084	18	12601											
COBLL1	22837	broad.mit.edu	37	chr2	165551002	165551002	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagttttcaaagtcttcagaTtttgtgtggatacctgacta	11	16	8	6	0	3	2	2	1	1	1	3	3	3	3	1	1	1	1	1	1	4	7			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:165551002T>A	uc010zcw.1	-	15	3339	c.3215A>T	c.(3214-3216)AAT>ATT	p.N1072I	COBLL1_uc002ucp.2_Missense_Mutation_p.N1005I|COBLL1_uc002ucq.2_Missense_Mutation_p.N967I|COBLL1_uc010zcx.1_Missense_Mutation_p.N1013I|COBLL1_uc002ucn.2_Missense_Mutation_p.N433I|COBLL1_uc002uco.2_Missense_Mutation_p.N736I	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	1043										ovary(2)|pancreas(1)	3						AGTCTTCAGATTTTGTGTGGA	0.478													10	76					0	0	0	0	A	165551002	A	A	165551002	3	1	63	1	0	0	0	0	1	0	0	0	3669	1493	52	5	498	5	COBLL1	2	165551002	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	24091713	165551002	77648371	19	12602											
UBR3	130507	broad.mit.edu	37	chr2	170936487	170936487	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtggtacttttgtatgccTgaaaggactttgctgcaagc	8	14	12	7	0	0	1	0	1	0	0	0	2	0	2	1	2	5	4	1	2	4	5			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr2:170936487T>C	uc010zdi.1	+	37	5363	c.5363T>C	c.(5362-5364)CTG>CCG	p.L1788P	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_Missense_Mutation_p.L609P|UBR3_uc002uft.3_Missense_Mutation_p.L645P|UBR3_uc010zdj.1_Missense_Mutation_p.L479P|UBR3_uc002ufu.3_Missense_Mutation_p.L294P	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1788	Cys-rich.				sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0						TTTGTATGCCTGAAAGGACTT	0.378													4	221					0	0	0	0	C	170936487	C	C	170936487	3	2	63	1	0	0	0	0	1	0	0	0	16971	1580	55	5	5509	5	UBR3	2	170936487	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	5385485	170936487	72262886	20	12603											
KIF9	64147	broad.mit.edu	37	chr3	47286984	47287007	+	Splice_Site	DEL	ACTTCCTGTTCCTGTTGGCTTGGG	-	-																															tcctgcgcaaagtggactccActtcctgttcctgttggctt																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:47286984_47287007delACTTCCTGTTCCTGTTGGCTTGGG	uc010hjp.2	-	15	1894	c.1290_splice	c.e15-1	p.S430_splice	KIF9_uc003cqx.2_Splice_Site_p.S430_splice|KIF9_uc003cqy.2_Splice_Site_p.S430_splice|KIF9_uc011bat.1_Splice_Site	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2						blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		AGTGGACTCCACTTCCTGTTCCTGTTGGCTTGGGAGACAGCAAG	0.509													---	---	---								-	47287007	-	-	47286984	8	5	63	1	0	1	0	1	0	0	1	0	8349	159	6	0	1097	0	KIF9	3	47286984	Splice_Site	DEL	ACTTCCTGTTCCTGTTGGCTTGGG	TCGA-CN-5366-01A-01D-1434-08		47286984	150735446	21	12604											
PBRM1	55193	broad.mit.edu	37	chr3	52637575	52637576	+	Frame_Shift_Ins	INS	-	TTTC	TTTC																															ttttagtttatcttcctctaINStttcttttggcaatttttcc																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:52637575_52637576insTTTC	uc003des.2	-	17	2752_2753	c.2740_2741insGAAA	c.(2740-2742)ATAfs	p.I914fs	PBRM1_uc003dex.2_Intron|PBRM1_uc003deq.2_Frame_Shift_Ins_p.I914fs|PBRM1_uc003der.2_Frame_Shift_Ins_p.I882fs|PBRM1_uc003det.2_Frame_Shift_Ins_p.I929fs|PBRM1_uc003deu.2_Frame_Shift_Ins_p.I929fs|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Frame_Shift_Ins_p.I914fs|PBRM1_uc010hmk.1_Frame_Shift_Ins_p.I914fs|PBRM1_uc003dey.2_Frame_Shift_Ins_p.I914fs|PBRM1_uc003dez.1_Frame_Shift_Ins_p.I914fs|PBRM1_uc003dfb.1_Frame_Shift_Ins_p.I827fs|PBRM1_uc003dfa.1_Frame_Shift_Ins_p.I260fs	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	914					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		ATCTTCCTCTATTTCTTTTGGC	0.332			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								---	---	---								TTTC	52637576	TTTC	TTTC	52637575	7	5	63	1	0	1	1	0	0	0	0	0	11545	449	16	0	2215	0	PBRM1	3	52637575	Frame_Shift_Ins	INS	-	TCGA-CN-5366-01A-01D-1434-08	5350591	52637575	145384855	22	12605											
PDZRN3	23024	broad.mit.edu	37	chr3	73440206	73440206	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgtcgtcttcatcgtccGtccggtagcacacagtgagg	8	10	11	12	4	2	1	1	1	1	0	6	1	4	1	2	2	1	2	2	2	2	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:73440206G>A	uc003dpl.1	-	6	1412	c.1316C>T	c.(1315-1317)ACG>ATG	p.T439M	PDZRN3_uc011bgh.1_Missense_Mutation_p.T96M|PDZRN3_uc010hoe.1_Missense_Mutation_p.T137M|PDZRN3_uc011bgf.1_Missense_Mutation_p.T156M|PDZRN3_uc011bgg.1_Missense_Mutation_p.T159M	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	439	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TTCATCGTCCGTCCGGTAGCA	0.448													30	308					0	0	0	0	A	73440206	A	A	73440206	3	1	63	1	0	0	0	0	1	0	0	0	11763	1145	40	1	1904	1	PDZRN3	3	73440206	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	20802631	73440206	124582224	23	12606											
CHST13	166012	broad.mit.edu	37	chr3	126255198	126255198	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctctatgacctggatcaggTaggtggacagaccctcgacc	9	8	12	12	1	2	2	1	1	1	1	3	5	2	4	3	4	0	2	3	4	2	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:126255198T>C	uc003eja.2	+	2	180	c.180_splice	c.e2+2	p.Q60_splice		NM_152889	NP_690849	Q8NET6	CHSTD_HUMAN	carbohydrate sulfotransferase 13						chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.151)		CTGGATCAGGTAGGTGGACAG	0.607													25	90					0	0	0	0	C	126255198	C	C	126255198	5	2	63	1	0	0	0	0	0	0	1	0	3416	1652	57	5	188	5	CHST13	3	126255198	Splice_Site	SNP	T	TCGA-CN-5366-01A-01D-1434-08	52814992	126255198	71767232	24	12607											
SLITRK3	22865	broad.mit.edu	37	chr3	164907436	164907436	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaaatgttattaaatcctcGctctttgcagttgacagtca	12	14	7	8	1	2	2	1	1	1	1	4	2	3	2	1	0	1	4	1	0	4	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr3:164907436G>A	uc003fej.3	-	2	1627	c.1183C>T	c.(1183-1185)CGA>TGA	p.R395*	SLITRK3_uc003fek.2_Nonsense_Mutation_p.R395*	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	395	LRRNT.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TTAAATCCTCGCTCTTTGCAG	0.418										HNSCC(40;0.11)			48	199					0	0	0	0	A	164907436	A	A	164907436	4	1	63	1	0	0	0	0	0	1	0	0	14808	1095	38	1	1754	1	SLITRK3	3	164907436	Nonsense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	38652238	164907436	33114994	25	12608											
PPAT	5471	broad.mit.edu	37	chr4	57269492	57269492	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggtgtcatcttgttcctgagGaggggtatacgccagtaact	8	12	13	8	1	2	1	1	1	1	0	3	2	3	2	2	4	2	3	2	4	3	5			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:57269492G>A	uc003hbr.2	-	4	680	c.478C>T	c.(478-480)CCT>TCT	p.P160S		NM_002703	NP_002694	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	160	Glutamine amidotransferase type-2.				glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	TGTTCCTGAGGAGGGGTATAC	0.423													35	131					0	0	0	0	A	57269492	A	A	57269492	3	1	63	1	0	0	0	0	1	0	0	0	12357	1174	41	2	1107	2	PPAT	4	57269492	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08		57269492	133884784	26	12609											
TET2	54790	broad.mit.edu	37	chr4	106156862	106156862	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatgaggcatcactgccatCaattcttcagtatcaaccca	13	11	5	12	0	5	1	4	1	1	0	5	1	5	1	2	1	2	2	2	1	4	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:106156862C>A	uc003hxk.2	+	3	2149	c.1763C>A	c.(1762-1764)TCA>TAA	p.S588*	TET2_uc011cez.1_Nonsense_Mutation_p.S609*|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Nonsense_Mutation_p.S588*|TET2_uc003hxi.1_Nonsense_Mutation_p.S588*	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	588					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TCACTGCCATCAATTCTTCAG	0.468			Mis N|F		MDS								31	84					2.81731e-10	3.02147e-10	1	0	A	106156862	A	A	106156862	4	1	63	1	0	0	0	0	0	1	0	0	15836	838	29	2	1765	2	TET2	4	106156862	Nonsense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	48887370	106156862	84997414	27	12610											
NDST4	64579	broad.mit.edu	37	chr4	115997944	115997944	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgagagtattggctctccacGaagagaaggacagtagggtc	12	8	14	7	1	1	2	0	1	1	2	3	6	1	3	1	3	0	3	1	3	4	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:115997944G>A	uc003ibu.2	-	2	928	c.249C>T	c.(247-249)TTC>TTT	p.F83F	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	83	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GGCTCTCCACGAAGAGAAGGA	0.433													17	129					0	0	0	0	A	115997944	A	A	115997944	2	1	63	1	0	0	0	0	0	0	0	1	10312	1049	37	1		1	NDST4	4	115997944	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	9841082	115997944	75156332	28	12611											
NDST3	9348	broad.mit.edu	37	chr4	119035975	119035975	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaaaggaactgaagaggaaGatgaaggagatgactgtctg	16	7	14	4	0	1	6	0	3	1	3	1	9	1	8	0	3	1	0	0	3	6	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:119035975G>A	uc003ibx.2	+	4	1487	c.1084G>A	c.(1084-1086)GAT>AAT	p.D362N	NDST3_uc011cgf.1_Intron	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	362	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						TGAAGAGGAAGATGAAGGAGA	0.423													14	87					0	0	0	0	A	119035975	A	A	119035975	3	1	63	1	0	0	0	0	1	0	0	0	10311	942	33	2	1094	2	NDST3	4	119035975	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	3038031	119035975	72118301	29	12612											
FBXW7	55294	broad.mit.edu	37	chr4	153247175	153247175	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacctgtaatgaatagactcTattagtatgcccctgcaacg	12	12	7	10	1	1	2	0	1	1	1	1	2	1	2	3	0	4	3	3	0	8	6			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:153247175T>C	uc003ims.2	-	10	1776	c.1627A>G	c.(1627-1629)AGA>GGA	p.R543G	FBXW7_uc011cii.1_Missense_Mutation_p.R543G|FBXW7_uc003imt.2_Missense_Mutation_p.R543G|FBXW7_uc011cih.1_Missense_Mutation_p.R367G|FBXW7_uc003imq.2_Missense_Mutation_p.R463G|FBXW7_uc003imr.2_Missense_Mutation_p.R425G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	543	WD 5.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R543K(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GAATAGACTCTATTAGTATGC	0.408			Mis|N|D|F		colorectal|endometrial|T-ALL								39	152					0	0	0	0	C	153247175	C	C	153247175	3	2	63	1	0	0	0	0	1	0	0	0	5801	1530	53	5	508	5	FBXW7	4	153247175	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	34211200	153247175	37907101	30	12613											
FAT1	2195	broad.mit.edu	37	chr4	187541516	187541516	+	Frame_Shift_Del	DEL	T	-	-																															caaacaccggcgcattatcaTtttggtcttctacaatgacc																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr4:187541516delT	uc003izf.2	-	10	6412	c.6224delA	c.(6223-6225)AATfs	p.N2075fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2075	Extracellular (Potential).|Cadherin 18.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CGCATTATCATTTTGGTCTTC	0.498										HNSCC(5;0.00058)			---	---	---								-	187541516	-	-	187541516	7	5	63	1	0	1	0	1	0	0	0	0	5721	1493	52	0	7614	0	FAT1	4	187541516	Frame_Shift_Del	DEL	T	TCGA-CN-5366-01A-01D-1434-08	34294341	187541516	3612760	31	12614											
DNAH5	1767	broad.mit.edu	37	chr5	13883148	13883148	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgggaatggccagagtgacGcttgcccggaaaatgggcaa	11	7	15	8	2	0	2	0	1	0	1	0	4	0	4	2	4	1	2	2	4	4	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:13883148G>A	uc003jfd.2	-	20	3081	c.3039C>T	c.(3037-3039)AGC>AGT	p.S1013S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1013	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCAGAGTGACGCTTGCCCGGA	0.478									Kartagener_syndrome				94	172					0	0	0	0	A	13883148	A	A	13883148	2	1	63	1	0	0	0	0	0	0	0	1	4626	1078	38	1		1	DNAH5	5	13883148	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08		13883148	167032112	32	12615											
FYB	2533	broad.mit.edu	37	chr5	39202059	39202060	+	Missense_Mutation	DNP	CC	AG	AG																															gggtggctgaattcttgtctCccttttccttttcctgactt																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:39202059_39202060CC>AG	uc003jls.2	-	1	1070_1071	c.1003_1004GG>CT	c.(1003-1005)GGA>CTA	p.G335L	FYB_uc003jlt.2_Missense_Mutation_p.G335L|FYB_uc003jlu.2_Missense_Mutation_p.G335L|FYB_uc011cpl.1_Missense_Mutation_p.G345L	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	335					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			ATTCTTGTCTCCCTTTTCCTTT	0.554													8	95					0	0	0	0	AG	39202060	AG	AG	39202059	3	1	63	1	0	0	0	0	1	0	0	0	6158	855	30	2	1557	2	FYB	5	39202059	Missense_Mutation	DNP	CC	TCGA-CN-5366-01A-01D-1434-08	25318911	39202059	141713201	33	12616											
C7	730	broad.mit.edu	37	chr5	40958326	40958326	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaccgtacacatttggtgcGgcgtgtgagcaaggagtcct	10	9	13	9	3	0	1	0	1	0	0	1	2	1	2	2	3	4	2	2	3	3	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:40958326G>A	uc003jmh.2	+	11	1566	c.1452G>A	c.(1450-1452)GCG>GCA	p.A484A	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	484	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				CATTTGGTGCGGCGTGTGAGC	0.502													17	126					0	0	0	0	A	40958326	A	A	40958326	2	1	63	1	0	0	0	0	0	0	0	1	2386	1103	39	1		1	C7	5	40958326	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	1756267	40958326	139956934	34	12617											
RASA1	5921	broad.mit.edu	37	chr5	86674262	86674264	+	In_Frame_Del	DEL	GGA	-	-																															acacttgcaagcaccttgatGgagcagtatatgaaagccac																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:86674262_86674264delGGA	uc003kiw.2	+	18	2512_2514	c.2394_2396delGGA	c.(2392-2397)ATGGAG>ATG	p.E799del	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_In_Frame_Del_p.E622del|RASA1_uc011ctv.1_In_Frame_Del_p.E632del|RASA1_uc011ctw.1_In_Frame_Del_p.E633del|RASA1_uc010jaw.2_In_Frame_Del_p.E621del	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	799	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		GCACCTTGATGGAGCAGTATATG	0.369													---	---	---								-	86674264	-	-	86674262	7	5	63	1	0	1	0	1	0	0	0	0	13125	1348	47	0	2476	0	RASA1	5	86674262	In_Frame_Del	DEL	GGA	TCGA-CN-5366-01A-01D-1434-08	45715936	86674262	94240998	35	12618											
FTMT	94033	broad.mit.edu	37	chr5	121187858	121187858	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccgccgccggcccctctcGggtgcgccagaacttccacc	4	5	11	21	5	1	1	0	0	1	1	3	1	2	1	8	2	2	0	8	2	1	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:121187858G>A	uc003kss.2	+	1	209	c.200G>A	c.(199-201)CGG>CAG	p.R67Q		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	67					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GGCCCCTCTCGGGTGCGCCAG	0.711													7	40					0	0	0	0	A	121187858	A	A	121187858	3	1	63	1	0	0	0	0	1	0	0	0	6119	1116	39	1	202	1	FTMT	5	121187858	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	34513596	121187858	59727402	36	12619											
PCDHGA3	56112	broad.mit.edu	37	chr5	140723931	140723931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaaattaacattctggttGaggataaattgaaaattttt	17	16	6	2	0	1	2	0	2	1	0	1	3	1	3	0	2	1	1	0	2	8	8			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:140723931G>A	uc003ljm.1	+	1	331	c.331G>A	c.(331-333)GAG>AAG	p.E111K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA3_uc011dap.1_Missense_Mutation_p.E111K	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	111	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTCTGGTTGAGGATAAATT	0.403													17	40					0	0	0	0	A	140723931	A	A	140723931	3	1	63	1	0	0	0	0	1	0	0	0	11609	1291	45	2	333	2	PCDHGA3	5	140723931	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	19536073	140723931	40191329	37	12620											
FAT2	2196	broad.mit.edu	37	chr5	150946563	150946563	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaggcatagtttttgccatCtgaggctgtaatcttcaggg	8	14	12	7	0	3	2	1	2	2	0	3	2	3	2	1	3	1	4	1	3	2	5			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:150946563C>T	uc003lue.3	-	1	1943	c.1930G>A	c.(1930-1932)GAT>AAT	p.D644N	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.D644N	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	644	Extracellular (Potential).|Cadherin 5.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTTTTGCCATCTGAGGCTGTA	0.418													36	115					0	0	0	0	T	150946563	T	T	150946563	3	4	63	1	0	0	0	0	1	0	0	0	5722	913	32	2	11211	2	FAT2	5	150946563	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	10222632	150946563	29968697	38	12621											
MAPK9	5601	broad.mit.edu	37	chr5	179688706	179688706	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgaattataccagctgaaTgcagatgtttaataccacaa	16	12	6	7	0	0	3	0	2	0	1	0	3	0	3	2	0	4	3	2	0	8	6			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr5:179688706T>A	uc003mls.3	-	5	699	c.428A>T	c.(427-429)CAT>CTT	p.H143L	MAPK9_uc003mlt.3_Missense_Mutation_p.H143L|MAPK9_uc010jlc.2_Missense_Mutation_p.H143L|MAPK9_uc003mlv.3_Missense_Mutation_p.H143L|MAPK9_uc011dgx.1_Missense_Mutation_p.H143L	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	143	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCAGCTGAATGCAGATGTTT	0.308													31	97					0	0	0	0	A	179688706	A	A	179688706	3	1	63	1	0	0	0	0	1	0	0	0	9340	1464	51	5	1000	5	MAPK9	5	179688706	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	28742143	179688706	1226554	39	12622											
COL12A1	1303	broad.mit.edu	37	chr6	75829169	75829169	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aactcagacttgacctcatcGctgtattgcacaaatgaaac	14	10	6	11	1	2	3	2	2	0	1	3	3	2	3	1	0	3	3	1	0	4	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr6:75829169G>A	uc003phs.2	-	45	7273	c.7107C>T	c.(7105-7107)AGC>AGT	p.S2369S	COL12A1_uc003pht.2_Silent_p.S1205S	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2369	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TGACCTCATCGCTGTATTGCA	0.433													39	136					0	0	0	0	A	75829169	A	A	75829169	2	1	63	1	0	0	0	0	0	0	0	1	3684	1078	38	1		1	COL12A1	6	75829169	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08		75829169	95285898	40	12623											
TXLNB	167838	broad.mit.edu	37	chr6	139563752	139563752	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcctctgctgctgctcGtgggggctgcctactgggct	2	11	14	14	1	1	0	0	0	1	0	3	0	2	0	2	3	6	6	2	3	1	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr6:139563752G>A	uc011eds.1	-	10	2131	c.1966C>T	c.(1966-1968)CGA>TGA	p.R656*		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	656						cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		GCTGCTGCTCGTGGGGGCTGC	0.642													47	93					0	0	0	0	A	139563752	A	A	139563752	4	1	63	1	0	0	0	0	0	1	0	0	16856	1153	40	1	92	1	TXLNB	6	139563752	Nonsense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	63734583	139563752	31551315	41	12624											
THBS2	7058	broad.mit.edu	37	chr6	169632834	169632834	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tatcggggcgggcagggcagGcagtggaagccaggctgagt	8	5	20	8	2	0	1	0	1	0	0	1	2	0	2	1	7	1	4	1	7	2	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr6:169632834G>A	uc003qwt.2	-	13	2105	c.1857C>T	c.(1855-1857)TGC>TGT	p.C619C		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	619	EGF-like 2; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGCAGGGCAGGCAGTGGAAGC	0.637													12	45					0	0	0	0	A	169632834	A	A	169632834	2	1	63	1	0	0	0	0	0	0	0	1	15920	1195	42	4		4	THBS2	6	169632834	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	30069082	169632834	1482233	42	12625											
RBAK	57786	broad.mit.edu	37	chr7	5105050	5105050	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaaccctatgaatgtaatGaatgtgggaaagtcttttct	14	13	9	5	0	2	3	0	2	2	1	2	4	2	4	1	1	1	1	1	1	6	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:5105050G>A	uc010kss.1	+	6	2287	c.1963G>A	c.(1963-1965)GAA>AAA	p.E655K	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.E655K	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	655	C2H2-type 15.|Interaction with AR.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TGAATGTAATGAATGTGGGAA	0.398													44	191					0	0	0	0	A	5105050	A	A	5105050	3	1	63	1	0	0	0	0	1	0	0	0	13165	1291	45	2	1977	2	RBAK	7	5105050	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08		5105050	154033613	43	12626											
HDAC9	9734	broad.mit.edu	37	chr7	18767227	18767227	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctggaacccacgcacacaCgtgcgctctctgtgcgccaa	8	7	9	17	4	1	0	0	0	1	0	3	1	2	1	3	1	3	2	3	1	2	0			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:18767227C>T	uc003suh.2	+	12	1788	c.1747C>T	c.(1747-1749)CGT>TGT	p.R583C	HDAC9_uc003sue.2_Missense_Mutation_p.R583C|HDAC9_uc011jyd.1_Missense_Mutation_p.R583C|HDAC9_uc003sui.2_Missense_Mutation_p.R586C|HDAC9_uc003suj.2_Missense_Mutation_p.R542C|HDAC9_uc003sua.1_Missense_Mutation_p.R561C|HDAC9_uc010kue.1_Missense_Mutation_p.R238C	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	583					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CACGCACACACGTGCGCTCTC	0.547													9	17					0	0	0	0	T	18767227	T	T	18767227	3	4	63	1	0	0	0	0	1	0	0	0	7053	536	19	1	1853	1	HDAC9	7	18767227	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	13662177	18767227	140371436	44	12627											
COL1A2	1278	broad.mit.edu	37	chr7	94052391	94052391	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagttggtccccctggcttCgctggtgagaagggtccctc	4	10	14	13	1	0	1	0	1	0	1	4	2	2	1	3	4	0	4	3	4	1	2	rs41317725		TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:94052391C>T	uc003ung.1	+	40	2997	c.2526C>T	c.(2524-2526)TTC>TTT	p.F842F	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	842			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCCCTGGCTTCGCTGGTGAGA	0.532										HNSCC(75;0.22)			33	175					0	0	0	0	T	94052391	T	T	94052391	2	4	63	1	0	0	0	0	0	0	0	1	3693	883	31	1		1	COL1A2	7	94052391	Silent	SNP	C	TCGA-CN-5366-01A-01D-1434-08	75285164	94052391	65086272	45	12628											
PPP1R3A	5506	broad.mit.edu	37	chr7	113558424	113558424	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accaacagaagtttcataacGtatacaaaactcaactttac	18	10	3	10	1	2	1	2	0	0	1	2	1	2	1	1	0	6	2	1	0	9	6	rs141223649	byFrequency	TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:113558424G>A	uc010ljy.1	-	1	659	c.628C>T	c.(628-630)CGT>TGT	p.R210C		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	210	CBM21.				glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GTTTCATAACGTATACAAAAC	0.348													26	140					0	0	0	0	A	113558424	A	A	113558424	3	1	63	1	0	0	0	0	1	0	0	0	12431	1145	40	1	2756	1	PPP1R3A	7	113558424	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	19506033	113558424	45580239	46	12629											
PTPRZ1	5803	broad.mit.edu	37	chr7	121676716	121676716	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atggcaaactgactgattatAtcaatgccaattatgttgat	14	14	7	6	0	1	3	1	3	0	0	1	3	1	3	1	1	2	2	1	1	6	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:121676716A>G	uc003vjy.2	+	18	5742	c.5347A>G	c.(5347-5349)ATC>GTC	p.I1783V	PTPRZ1_uc003vjz.2_Missense_Mutation_p.I916V|PTPRZ1_uc011knt.1_Missense_Mutation_p.I373V	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1783	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						GACTGATTATATCAATGCCAA	0.303													23	65					0	0	0	0	G	121676716	G	G	121676716	3	3	63	1	0	0	0	0	1	0	0	0	12879	449	16	5	5417	5	PTPRZ1	7	121676716	Missense_Mutation	SNP	A	TCGA-CN-5366-01A-01D-1434-08	8118292	121676716	37461947	47	12630											
GRM8	2918	broad.mit.edu	37	chr7	126410117	126410117	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccgagcaattcgctccaGccctgcaaaataaaaaagta	16	7	6	12	2	0	0	0	0	0	0	3	1	2	0	3	0	3	4	3	0	7	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:126410117G>A	uc003vlr.2	-	6	1470	c.1159C>T	c.(1159-1161)CTG>TTG	p.L387L	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.L387L|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Silent_p.L108L	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	387	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	ATTCGCTCCAGCCCTGCAAAA	0.378										HNSCC(24;0.065)			19	39					0	0	0	0	A	126410117	A	A	126410117	2	1	63	1	0	0	0	0	0	0	0	1	6842	962	34	4		4	GRM8	7	126410117	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	4733401	126410117	32728546	48	12631											
ESYT2	57488	broad.mit.edu	37	chr7	158560437	158560437	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caccagatagtttgatattaTatccaaaatgatagtatctg	15	14	6	6	0	1	3	0	2	1	1	2	3	2	3	2	0	0	2	2	0	8	7			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr7:158560437T>C	uc003wob.1	-	8	1042	c.976A>G	c.(976-978)ATA>GTA	p.I326V	ESYT2_uc003woc.1_Missense_Mutation_p.I150V|ESYT2_uc003wod.1_Missense_Mutation_p.I326V	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	354						integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						TTTGATATTATATCCAAAATG	0.408													11	78					0	0	0	0	C	158560437	C	C	158560437	3	2	63	1	0	0	0	0	1	0	0	0	5289	1406	49	5	1765	5	ESYT2	7	158560437	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	32150320	158560437	578226	49	12632											
HR	55806	broad.mit.edu	37	chr8	21976686	21976686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgaggacctacctttctgtgCccggtgccaggcaggcagtg	6	8	14	13	2	1	0	0	0	1	0	1	2	1	1	4	4	3	2	4	4	1	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr8:21976686C>T	uc003xas.2	-	15	3753	c.3088G>A	c.(3088-3090)GCA>ACA	p.A1030T	HR_uc003xat.2_Missense_Mutation_p.A1030T	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	1030	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CCTTTCTGTGCCCGGTGCCAG	0.652													3	64					0	0	0	0	T	21976686	T	T	21976686	3	4	63	1	0	0	0	0	1	0	0	0	7386	739	26	4	501	4	HR	8	21976686	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08		21976686	124387336	50	12633											
C8orf34	116328	broad.mit.edu	37	chr8	69621297	69621297	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actccattctccagatgaaaAaatcccagattcattcggta	14	11	5	11	1	2	3	1	1	1	2	6	3	4	3	3	1	0	1	3	1	4	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr8:69621297A>T	uc010lyz.2	+	9	1101	c.1052A>T	c.(1051-1053)AAA>ATA	p.K351I	C8orf34_uc003xyb.2_Missense_Mutation_p.K326I	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	351					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CCAGATGAAAAAATCCCAGAT	0.328													28	64					0	0	0	0	T	69621297	T	T	69621297	3	4	63	1	0	0	0	0	1	0	0	0	2434	14	1	5	1007	5	C8orf34	8	69621297	Missense_Mutation	SNP	A	TCGA-CN-5366-01A-01D-1434-08	47644611	69621297	76742725	51	12634											
ZFHX4	79776	broad.mit.edu	37	chr8	77616422	77616422	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgataatgaggtgccagaGaaagttgcagggatggagcc	12	8	15	6	0	0	3	0	2	0	1	0	6	0	5	2	3	3	2	2	3	2	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr8:77616422G>C	uc003yav.2	+	2	486	c.99G>C	c.(97-99)GAG>GAC	p.E33D	ZFHX4_uc003yat.1_Missense_Mutation_p.E33D|ZFHX4_uc003yau.1_Missense_Mutation_p.E33D|ZFHX4_uc003yaw.1_Missense_Mutation_p.E33D	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	33						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGGTGCCAGAGAAAGTTGCAG	0.502										HNSCC(33;0.089)			16	70					0	0	0	0	C	77616422	C	C	77616422	3	2	63	1	0	0	0	0	1	0	0	0	17702	933	33	2	101	2	ZFHX4	8	77616422	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	7995125	77616422	68747600	52	12635											
C8orf31	286122	broad.mit.edu	37	chr8	144130635	144130635	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcattgcaggattctctcGgcaccacgggaaccaccttc	8	10	9	14	2	2	0	1	0	1	0	5	2	2	2	3	3	2	2	3	3	1	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr8:144130635G>A	uc003yxp.1	+	5	717	c.365G>A	c.(364-366)CGG>CAG	p.R122Q	C8orf31_uc003yxq.1_RNA|C8orf31_uc003yxr.1_RNA	NM_173687	NP_775958	Q8N9H6	CH031_HUMAN	hypothetical protein LOC286122	122										ovary(1)	1	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ggattctctcggcaccacggg	0.02													19	130					0	0	0	0	A	144130635	A	A	144130635	3	1	63	1	0	0	0	0	1	0	0	0	2432	1116	39	1	379	1	C8orf31	8	144130635	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	66514213	144130635	2233387	53	12636											
EPPK1	83481	broad.mit.edu	37	chr8	144940258	144940258	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggttctcgtgcgtgttgggGtcgaagaagcccttggtgtc	5	12	16	8	3	1	1	0	0	1	1	4	2	1	1	1	4	2	2	1	4	2	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr8:144940258G>A	uc003zaa.1	-	2	15187	c.15174C>T	c.(15172-15174)GAC>GAT	p.D5058D		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5058	Plectin 65.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCGTGTTGGGGTCGAAGAAGC	0.632													19	527					0	0	0	0	A	144940258	A	A	144940258	2	1	63	1	0	0	0	0	0	0	0	1	5214	1252	44	4		4	EPPK1	8	144940258	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	809623	144940258	1423764	54	12637											
HAUS6	54801	broad.mit.edu	37	chr9	19058811	19058811	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactttctcttcagtcaaatGagactggccaaaatctgata	14	12	6	9	0	4	2	2	2	2	1	5	3	4	2	1	1	1	0	1	1	5	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr9:19058811G>T	uc003znk.2	-	16	2207	c.1954C>A	c.(1954-1956)CAT>AAT	p.H652N	HAUS6_uc011lmz.1_Missense_Mutation_p.H372N|HAUS6_uc003znl.1_Missense_Mutation_p.H516N	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	652					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2						TCAGTCAAATGAGACTGGCCA	0.398													47	113					4.01344e-20	4.46608e-20	1	0	T	19058811	T	T	19058811	3	4	63	1	0	0	0	0	1	0	0	0	7009	1290	45	2	921	2	HAUS6	9	19058811	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08		19058811	122154620	55	12638											
FAM75C1	441452	broad.mit.edu	37	chr9	90535829	90535829	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccagcccctgtcccatctggGgcctgagtcccaacccttta	6	9	8	18	0	1	1	0	1	1	0	3	1	3	1	7	2	2	0	7	2	2	2	rs144903965	by1000genomes	TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr9:90535829G>A	uc010mqi.2	+	4	1036	c.1007G>A	c.(1006-1008)GGG>GAG	p.G336E	FAM75C1_uc004apq.3_Missense_Mutation_p.G319E	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						TCCCATCTGGGGCCTGAGTCC	0.567													28	265					0	0	0	0	A	90535829	A	A	90535829	3	1	63	1	0	0	0	0	1	0	0	0	5655	1232	43	4	1021	4	FAM75C1	9	90535829	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	71477018	90535829	50677602	56	12639											
TLR4	7099	broad.mit.edu	37	chr9	120466838	120466838	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaagctgggagccctgcGtggaggtatgtggctggagt	8	8	18	7	1	0	1	0	0	0	1	0	4	0	4	1	5	3	3	1	5	2	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr9:120466838G>A	uc004bjz.2	+	1	379	c.88G>A	c.(88-90)GTG>ATG	p.V30M	TLR4_uc004bka.2_Translation_Start_Site|TLR4_uc004bkb.2_Translation_Start_Site	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	30	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						GGAGCCCTGCGTGGAGGTATG	0.542													21	38					0	0	0	0	A	120466838	A	A	120466838	3	1	63	1	0	0	0	0	1	0	0	0	16019	1145	40	1	90	1	TLR4	9	120466838	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	29931009	120466838	20746593	57	12640											
ANK3	288	broad.mit.edu	37	chr10	61840373	61840373	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtcgtctatctgttttctCaatctgaaaaggaaaaaaaa	15	13	6	7	1	4	1	1	1	4	0	6	2	4	2	0	1	0	1	0	1	8	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr10:61840373C>G	uc001jky.2	-	36	4546	c.4354G>C	c.(4354-4356)GAG>CAG	p.E1452Q	ANK3_uc001jkw.2_Missense_Mutation_p.E577Q|ANK3_uc009xpa.2_Missense_Mutation_p.E577Q|ANK3_uc001jkx.2_Missense_Mutation_p.E621Q|ANK3_uc010qih.1_Missense_Mutation_p.E1444Q|ANK3_uc001jkz.3_Missense_Mutation_p.E1437Q|ANK3_uc001jla.1_Missense_Mutation_p.E509Q|ANK3_uc001jkv.2_5'UTR|ANK3_uc009xpb.1_5'Flank|ANK3_uc009xpc.1_5'Flank	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1452					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TCTGTTTTCTCAATCTGAAAA	0.383													7	30					0	0	0	0	G	61840373	G	G	61840373	3	3	63	1	0	0	0	0	1	0	0	0	622	835	29	2	9124	2	ANK3	10	61840373	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08		61840373	73694374	58	12641											
LRRTM3	347731	broad.mit.edu	37	chr10	68688015	68688015	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcatggaagcggtaccctgcGagcatgaagcagctgcagca	11	6	13	11	2	1	1	1	1	0	0	1	3	1	2	1	2	8	6	1	2	3	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr10:68688015G>C	uc001jmz.1	+	2	1891	c.1341G>C	c.(1339-1341)GCG>GCC	p.A447A	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Silent_p.A447A	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	447	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GGTACCCTGCGAGCATGAAGC	0.522													17	113					0	0	0	0	C	68688015	C	C	68688015	2	2	63	1	0	0	0	0	0	0	0	1	9091	1045	37	3		3	LRRTM3	10	68688015	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	6847642	68688015	66846732	59	12642											
KIAA1274	27143	broad.mit.edu	37	chr10	72298066	72298066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttgccctcagtttcagcCgctggctgtgtgcccaccct	3	12	9	17	1	2	0	2	0	0	0	2	0	2	0	5	1	3	3	5	1	0	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr10:72298066C>T	uc001jrd.3	+	12	1635	c.1354C>T	c.(1354-1356)CGC>TGC	p.R452C	KIAA1274_uc001jre.3_5'Flank	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	452										ovary(2)|central_nervous_system(1)	3						CAGTTTCAGCCGCTGGCTGTG	0.667													5	63					0	0	0	0	T	72298066	T	T	72298066	3	4	63	1	0	0	0	0	1	0	0	0	8259	652	23	1	1396	1	KIAA1274	10	72298066	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	3610051	72298066	63236681	60	12643											
HPS1	3257	broad.mit.edu	37	chr10	100202886	100202886	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaccctgcactcacctcttCttcctcattctctgactgcc	5	14	3	19	0	5	1	2	1	3	0	7	1	6	1	4	0	3	1	4	0	1	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr10:100202886C>T	uc010qpf.1	-	3	358	c.112G>A	c.(112-114)GAA>AAA	p.E38K	HPS1_uc001kpi.1_Missense_Mutation_p.E38K|HPS1_uc001kpk.1_Missense_Mutation_p.E38K|HPS1_uc009xwb.2_RNA|HPS1_uc010qph.1_Missense_Mutation_p.E38K|HPS1_uc001kpl.2_Missense_Mutation_p.E38K|HPS1_uc001kpm.1_RNA	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	38	Poly-Glu.				lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		CTCACCTCTTCTTCCTCATTC	0.557									Hermansky-Pudlak_syndrome				53	193					0	0	0	0	T	100202886	T	T	100202886	3	4	63	1	0	0	0	0	1	0	0	0	7378	922	32	2	2100	2	HPS1	10	100202886	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	27904820	100202886	35331861	61	12644											
C10orf137	26098	broad.mit.edu	37	chr10	127412503	127412503	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactctttatgagatcgtctCaggtaatgcttttgtgaaaa	12	15	8	6	1	2	2	1	2	2	1	4	3	2	2	0	1	2	2	0	1	5	5			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr10:127412503C>T	uc001liq.1	+	4	801	c.508C>T	c.(508-510)CAG>TAG	p.Q170*	C10orf137_uc001lin.2_Nonsense_Mutation_p.Q170*|C10orf137_uc001lio.1_Nonsense_Mutation_p.Q170*|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GAGATCGTCTCAGGTAATGCT	0.398													21	129					0	0	0	0	T	127412503	T	T	127412503	4	4	63	1	0	0	0	0	0	1	0	0	1600	827	29	2	522	2	C10orf137	10	127412503	Nonsense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	27209617	127412503	8122244	62	12645											
OR51F1	256892	broad.mit.edu	37	chr11	4790981	4790981	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatacatgggttcatggagaCtctgctgggtaatgatgaca	12	11	12	6	0	2	3	1	2	1	1	2	4	2	3	0	3	2	3	0	3	3	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:4790981C>G	uc010qyl.1	-	1	167	c.167G>C	c.(166-168)AGT>ACT	p.S56T		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	56						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		TTCATGGAGACTCTGCTGGGT	0.453													8	41					0	0	0	0	G	4790981	G	G	4790981	3	3	63	1	0	0	0	0	1	0	0	0	11150	565	20	4	774	4	OR51F1	11	4790981	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08		4790981	130215535	63	12646											
OR52N4	390072	broad.mit.edu	37	chr11	5776889	5776889	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagatacgagactgtgtcAtaaggatcctttcaggttct	12	12	9	8	1	3	2	2	0	1	2	4	4	4	3	1	2	2	1	1	2	3	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:5776889A>T	uc001mbu.2	+	1	967	c.919A>T	c.(919-921)ATA>TTA	p.I307L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		AGACTGTGTCATAAGGATCCT	0.413													39	93					0	0	0	0	T	5776889	T	T	5776889	3	4	63	1	0	0	0	0	1	0	0	0	11183	217	8	5	921	5	OR52N4	11	5776889	Missense_Mutation	SNP	A	TCGA-CN-5366-01A-01D-1434-08	985908	5776889	129229627	64	12647											
BBOX1	8424	broad.mit.edu	37	chr11	27148982	27148982	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttcgtatcttaaggcagagGgtggagaatggaaactgaag	13	9	14	5	1	1	3	0	1	1	2	2	5	1	4	0	4	1	2	0	4	5	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:27148982G>T	uc001mre.1	+	9	1514	c.1146G>T	c.(1144-1146)AGG>AGT	p.R382S	BBOX1_uc009yih.1_Missense_Mutation_p.R382S|BBOX1_uc001mrg.1_Missense_Mutation_p.R382S	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	382					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	TAAGGCAGAGGGTGGAGAATG	0.418													5	113					0.000602214	0.000618943	1	0	T	27148982	T	T	27148982	3	4	63	1	0	0	0	0	1	0	0	0	1336	1223	43	4	1172	4	BBOX1	11	27148982	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	21372093	27148982	107857534	65	12648											
FBXO3	26273	broad.mit.edu	37	chr11	33772131	33772131	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggtggatgtacagagctaaGttctggcagaaacgatgtgg	11	9	16	5	1	1	2	0	0	1	2	1	4	1	3	0	4	3	4	0	4	3	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:33772131G>C	uc001muz.2	-	8	914	c.886C>G	c.(886-888)CTT>GTT	p.L296V	FBXO3_uc010rej.1_5'UTR|FBXO3_uc001muy.2_Missense_Mutation_p.L183V|FBXO3_uc009ykb.2_RNA|FBXO3_uc001mva.1_Missense_Mutation_p.L296V|FBXO3_uc001mvb.1_Missense_Mutation_p.L291V|FBXO3_uc010rek.1_RNA	NM_012175	NP_036307	Q9UK99	FBX3_HUMAN	F-box only protein 3 isoform 1	296	ApaG.				proteolysis	nucleus	ubiquitin-protein ligase activity			pancreas(1)	1		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		ACAGAGCTAAGTTCTGGCAGA	0.388													6	71					0	0	0	0	C	33772131	C	C	33772131	3	2	63	1	0	0	0	0	1	0	0	0	5771	1029	36	4	554	4	FBXO3	11	33772131	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	6623149	33772131	101234385	66	12649											
CATSPER1	117144	broad.mit.edu	37	chr11	65792843	65792843	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcagggccgggggcatcGtgaatcaggctccgggatgt	7	6	18	10	3	1	1	1	1	0	0	3	2	2	2	2	5	1	4	2	5	1	0			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:65792843G>A	uc001ogt.2	-	1	1146	c.1008C>T	c.(1006-1008)CAC>CAT	p.H336H		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	336	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						CGGGGGCATCGTGAATCAGGC	0.562													17	106					0	0	0	0	A	65792843	A	A	65792843	2	1	63	1	0	0	0	0	0	0	0	1	2699	1136	40	1		1	CATSPER1	11	65792843	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	32020712	65792843	69213673	67	12650											
NADSYN1	55191	broad.mit.edu	37	chr11	71185569	71185569	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagttttctctggatgaCgtggtaatgagcgggcctgg	6	12	14	9	2	1	2	0	2	1	0	3	3	2	3	2	4	1	2	2	4	1	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:71185569C>T	uc001oqn.2	+	9	921	c.795C>T	c.(793-795)GAC>GAT	p.D265D	NADSYN1_uc001oqm.2_RNA|NADSYN1_uc001oqo.2_Translation_Start_Site	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	265	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTCTGGATGACGTGGTAATGA	0.597													21	318					0	0	0	0	T	71185569	T	T	71185569	2	4	63	1	0	0	0	0	0	0	0	1	10191	535	19	1		1	NADSYN1	11	71185569	Silent	SNP	C	TCGA-CN-5366-01A-01D-1434-08	5392726	71185569	63820947	68	12651											
UCP3	7352	broad.mit.edu	37	chr11	73717337	73717337	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaggggctgcagggaccctCagtccgcaccatggtcagga	8	6	15	12	1	2	0	2	0	0	0	3	2	3	2	3	5	1	4	3	5	1	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr11:73717337C>G	uc001our.2	-	3	569	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	UCP3_uc001ous.2_Missense_Mutation_p.E72Q	NM_003356	NP_003347	P55916	UCP3_HUMAN	uncoupling protein 3 isoform UCP3L	72	Solcar 1.				mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			pancreas(1)	1	Breast(11;2.08e-05)					CAGGGACCCTCAGTCCGCACC	0.652													6	20					0	0	0	0	G	73717337	G	G	73717337	3	3	63	1	0	0	0	0	1	0	0	0	17000	835	29	2	748	2	UCP3	11	73717337	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	2531768	73717337	61289179	69	12652											
CD163L1	283316	broad.mit.edu	37	chr12	7527092	7527092	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtcgtgctgcccccagcCgcgggaagggcactgccaca	7	4	14	16	3	0	0	0	0	0	0	1	1	0	1	4	2	4	3	4	2	1	0	rs149805278		TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:7527092C>T	uc001qsy.2	-	13	3381	c.3355G>A	c.(3355-3357)GGC>AGC	p.G1119S	CD163L1_uc010sge.1_Missense_Mutation_p.G1129S	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1119	SRCR 10.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TGCCCCCAGCCGCGGGAAGGG	0.617													20	97					0	0	0	0	T	7527092	T	T	7527092	3	4	63	1	0	0	0	0	1	0	0	0	2983	652	23	1	1034	1	CD163L1	12	7527092	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08		7527092	126324803	70	12653											
CASC1	55259	broad.mit.edu	37	chr12	25308247	25308247	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagagaaatcagtcctacctGagaaagcaatttagtttcct	15	11	7	8	0	1	2	1	1	0	2	3	4	3	2	3	0	2	2	3	0	6	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:25308247G>A	uc001rgl.2	-	4	362	c.280C>T	c.(280-282)CAG>TAG	p.Q94*	CASC1_uc001rgk.2_Nonsense_Mutation_p.Q100*|CASC1_uc001rgm.3_Nonsense_Mutation_p.Q158*|CASC1_uc001rgj.2_Nonsense_Mutation_p.Q54*|CASC1_uc010sje.1_Nonsense_Mutation_p.Q35*|CASC1_uc010sjf.1_5'UTR|CASC1_uc010sjg.1_Nonsense_Mutation_p.Q94*|CASC1_uc010sjh.1_RNA	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	94										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			AGTCCTACCTGAGAAAGCAAT	0.348													16	74					0	0	0	0	A	25308247	A	A	25308247	4	1	63	1	0	0	0	0	0	1	0	0	2672	1299	45	2	1918	2	CASC1	12	25308247	Nonsense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	17781155	25308247	108543648	71	12654											
KRT72	140807	broad.mit.edu	37	chr12	52994829	52994829	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accttgtcgatgaaggaggcGaacttgttgtttagcgcctt	8	13	12	8	3	0	1	0	1	0	0	1	4	0	2	2	2	2	2	2	2	3	6			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:52994829G>A	uc001sar.2	-	1	494	c.408C>T	c.(406-408)TTC>TTT	p.F136F	KRT72_uc001saq.2_Silent_p.F136F|KRT72_uc010sns.1_Silent_p.F136F|KRT72_uc010snt.1_5'UTR	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	136	Coil 1A.|Rod.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		TGAAGGAGGCGAACTTGTTGT	0.537													24	101					0	0	0	0	A	52994829	A	A	52994829	2	1	63	1	0	0	0	0	0	0	0	1	8524	1049	37	1		1	KRT72	12	52994829	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	27686582	52994829	80857066	72	12655											
ITGA5	3678	broad.mit.edu	37	chr12	54795429	54795429	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaggaaaccacgtcgcttTgcgagttgttgagattcttg	10	12	12	7	3	1	1	0	1	1	1	2	5	1	2	1	1	2	3	1	1	2	5			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:54795429T>A	uc001sga.2	-	23	2395	c.2327A>T	c.(2326-2328)CAA>CTA	p.Q776L		NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	776	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						CACGTCGCTTTGCGAGTTGTT	0.602													52	172					0	0	0	0	A	54795429	A	A	54795429	3	1	63	1	0	0	0	0	1	0	0	0	7918	1812	63	5	854	5	ITGA5	12	54795429	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	1800600	54795429	79056466	73	12656											
NACA	4666	broad.mit.edu	37	chr12	57106906	57106906	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgttttcttgaatgtttgaGacagcttcaccttgaacttt	8	18	8	7	0	2	3	1	3	1	1	2	4	2	3	1	0	2	3	1	0	2	7			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:57106906G>C	uc001slz.2	-	6	799	c.450C>G	c.(448-450)GTC>GTG	p.V150V	NACA_uc001sly.2_Silent_p.V150V|NACA_uc009zoy.1_Silent_p.V2013V|NACA_uc001smc.2_Silent_p.V150V|NACA_uc001sma.2_Silent_p.V860V|NACA_uc001smb.2_Silent_p.V150V|NACA_uc010squ.1_RNA	NM_001113201	NP_001106672	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	150					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1						GAATGTTTGAGACAGCTTCAC	0.403			T	BCL6	NHL								20	118					0	0	0	0	C	57106906	C	C	57106906	2	2	63	1	0	0	0	0	0	0	0	1	10186	929	33	2		2	NACA	12	57106906	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	2311477	57106906	76744989	74	12657											
ALX1	8092	broad.mit.edu	37	chr12	85680722	85680722	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattttgctgccacctatgAtatatcagttttgccaagga	10	14	7	10	0	1	1	1	1	0	0	1	2	1	2	4	1	3	2	4	1	4	7			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:85680722A>C	uc001tae.3	+	3	627	c.623A>C	c.(622-624)GAT>GCT	p.D208A		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	208					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		GCCACCTATGATATATCAGTT	0.368													37	104					0	0	0	0	C	85680722	C	C	85680722	3	2	63	1	0	0	0	0	1	0	0	0	556	333	12	5	633	5	ALX1	12	85680722	Missense_Mutation	SNP	A	TCGA-CN-5366-01A-01D-1434-08	28573816	85680722	48171173	75	12658											
STAB2	55576	broad.mit.edu	37	chr12	104067694	104067694	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctctttcagaatgcctgtGcgttcacggaacatgcaata	10	12	8	11	2	3	1	2	0	1	1	4	2	4	2	2	1	4	2	2	1	4	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr12:104067694G>A	uc001tjw.2	+	23	2567	c.2381G>A	c.(2380-2382)TGC>TAC	p.C794Y		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	794	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GAATGCCTGTGCGTTCACGGA	0.587													7	57					0	0	0	0	A	104067694	A	A	104067694	3	1	63	1	0	0	0	0	1	0	0	0	15304	1319	46	4	2471	4	STAB2	12	104067694	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	18386972	104067694	29784201	76	12659											
TFDP1	7027	broad.mit.edu	37	chr13	114285981	114285981	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcaaacaccctggTggtaggaagcccacacaccc	11	4	11	15	1	1	0	1	0	0	0	1	1	1	1	3	4	3	2	3	4	3	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr13:114285981T>C	uc001vtw.2	+	5	442	c.230T>C	c.(229-231)GTG>GCG	p.V77A	TFDP1_uc010tkd.1_Intron|TFDP1_uc010tke.1_Intron|TFDP1_uc001vty.3_Missense_Mutation_p.V77A|TFDP1_uc001vtx.2_5'Flank|TFDP1_uc010agx.2_Missense_Mutation_p.V77A	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	77					cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			AACACCCTGGTGGTAGGAAGC	0.592										TSP Lung(29;0.18)			23	79					0	0	0	0	C	114285981	C	C	114285981	3	2	63	1	0	0	0	0	1	0	0	0	15863	1696	59	5	244	5	TFDP1	13	114285981	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08		114285981	883897	77	12660											
NIN	51199	broad.mit.edu	37	chr14	51228570	51228570	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgttgttctttcatctgttCaatgaccagctctgcctcaa	8	16	6	11	0	6	1	3	1	3	0	6	1	6	1	2	0	2	4	2	0	2	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr14:51228570C>G	uc001wym.2	-	16	2025	c.1834G>C	c.(1834-1836)GAA>CAA	p.E612Q	NIN_uc001wyi.2_Missense_Mutation_p.E612Q|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.E612Q|NIN_uc010tqp.1_Missense_Mutation_p.E618Q|NIN_uc001wyo.2_Missense_Mutation_p.E612Q	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	612					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TTCATCTGTTCAATGACCAGC	0.438			T	PDGFRB	MPD								57	329					0	0	0	0	G	51228570	G	G	51228570	3	3	63	1	0	0	0	0	1	0	0	0	10471	835	29	2	4779	2	NIN	14	51228570	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08		51228570	56120970	78	12661											
GTF2A1	2957	broad.mit.edu	37	chr14	81670382	81670382	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgctgttgaacttgcagtaGaagctgctgctcttctgaat	8	14	10	9	0	2	3	0	2	2	1	2	3	2	3	0	0	6	7	0	0	4	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr14:81670382G>C	uc001xvf.1	-	3	631	c.199C>G	c.(199-201)CTA>GTA	p.L67V	GTF2A1_uc010atb.1_Missense_Mutation_p.L17V|GTF2A1_uc001xvg.1_Missense_Mutation_p.L28V|GTF2A1_uc001xvh.1_Missense_Mutation_p.L28V|SNORA79_uc001xvi.1_5'Flank	NM_015859	NP_056943	P52655	TF2AA_HUMAN	TFIIA alpha, p55 isoform 1	67					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|transcription factor TFIIA complex	DNA binding|protein binding|protein heterodimerization activity|TBP-class protein binding|transcription coactivator activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0287)		acttgcagtagaagctgctgc	0.204													32	89					0	0	0	0	C	81670382	C	C	81670382	3	2	63	1	0	0	0	0	1	0	0	0	6891	933	33	2	959	2	GTF2A1	14	81670382	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	30441812	81670382	25679158	79	12662											
OR4N4	283694	broad.mit.edu	37	chr15	22383148	22383148	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtcatcctctgccatgttCgtagggcagcttctgaaggg	7	11	12	11	1	3	1	1	1	2	0	5	1	4	1	2	2	2	4	2	2	2	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr15:22383148C>T	uc001yuc.1	+	7	1657	c.676C>T	c.(676-678)CGT>TGT	p.R226C	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Missense_Mutation_p.R226C	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTGCCATGTTCGTAGGGCAGC	0.483													24	321					0	0	0	0	T	22383148	T	T	22383148	3	4	63	1	0	0	0	0	1	0	0	0	11132	884	31	1	678	1	OR4N4	15	22383148	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08		22383148	80148244	80	12663											
SNRPN	6638	broad.mit.edu	37	chr15	25223367	25223367	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctcctccacctggtatgaGaccacccatgggcccaccaa	9	6	9	17	0	0	1	0	1	0	1	2	2	2	1	7	3	0	2	7	3	2	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr15:25223367G>C	uc001ywp.1	+	12	1477	c.587G>C	c.(586-588)AGA>ACA	p.R196T	SNRPN_uc001ywq.1_Missense_Mutation_p.R196T|SNRPN_uc001ywr.1_Missense_Mutation_p.R196T|SNRPN_uc001yws.1_Missense_Mutation_p.R196T|SNRPN_uc001ywt.1_Missense_Mutation_p.R196T|SNRPN_uc001ywv.1_Missense_Mutation_p.R199T|SNRPN_uc001yww.1_Missense_Mutation_p.R196T|SNRPN_uc001ywx.1_Missense_Mutation_p.R196T|SNRPN_uc001ywz.1_RNA|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	196	Repeat-rich region.|				RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		CCTGGTATGAGACCACCCATG	0.507									Prader-Willi_syndrome				23	249					0	0	0	0	C	25223367	C	C	25223367	3	2	63	1	0	0	0	0	1	0	0	0	14934	942	33	2	609	2	SNRPN	15	25223367	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	2840219	25223367	77308025	81	12664											
NEDD4	4734	broad.mit.edu	37	chr15	56132818	56132818	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	actaaccatccaacagtttgCcatgataaactgccattcca	14	10	4	13	0	0	1	0	1	0	0	2	1	2	1	5	0	5	1	5	0	4	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr15:56132818C>T	uc002adj.2	-	16	3503	c.3203G>A	c.(3202-3204)GGC>GAC	p.G1068D	NEDD4_uc002adl.2_Missense_Mutation_p.G649D|NEDD4_uc002adi.2_Missense_Mutation_p.G996D|NEDD4_uc010ugj.1_Missense_Mutation_p.G1052D|NEDD4_uc010bfm.2_Missense_Mutation_p.G1051D|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1068	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		CAACAGTTTGCCATGATAAAC	0.338													5	203					0	0	0	0	T	56132818	T	T	56132818	3	4	63	1	0	0	0	0	1	0	0	0	10364	739	26	4	796	4	NEDD4	15	56132818	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	30909451	56132818	46398574	82	12665											
SIN3A	25942	broad.mit.edu	37	chr15	75704051	75704051	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaagtgggggagtctgctGactggccggagtatgtgctt	6	11	18	6	1	1	1	0	1	1	0	1	4	1	4	1	5	2	3	1	5	2	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr15:75704051G>T	uc002bai.2	-	6	1049	c.790C>A	c.(790-792)CAG>AAG	p.Q264K	SIN3A_uc002baj.2_Missense_Mutation_p.Q264K|SIN3A_uc010uml.1_Missense_Mutation_p.Q264K	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	264	Interaction with REST (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						GGAGTCTGCTGACTGGCCGGA	0.512													55	193					4.33383e-22	4.89624e-22	1	0	T	75704051	T	T	75704051	3	4	63	1	0	0	0	0	1	0	0	0	14390	1299	45	2	3095	2	SIN3A	15	75704051	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	19571233	75704051	26827341	83	12666											
LINS1	55180	broad.mit.edu	37	chr15	101120724	101120724	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctcctttgcatggaactcGgttttgacagacaatatccg	9	13	9	10	2	0	2	0	1	0	1	3	3	2	3	2	2	3	3	2	2	3	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr15:101120724G>A	uc002bwe.2	-	3	615	c.324C>T	c.(322-324)ACC>ACT	p.T108T	LINS1_uc002bwf.2_Silent_p.T108T|LINS1_uc002bwg.2_Silent_p.T108T|LINS1_uc002bwh.2_Silent_p.T108T|LINS1_uc010usa.1_Intron|LINS1_uc002bwi.2_Silent_p.T108T	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	108											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			CATGGAACTCGGTTTTGACAG	0.383													11	108					0	0	0	0	A	101120724	A	A	101120724	2	1	63	1	0	0	0	0	0	0	0	1	8860	1103	39	1		1	LINS1	15	101120724	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	25416673	101120724	1410668	84	12667											
SETD1A	9739	broad.mit.edu	37	chr16	30977267	30977267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcagacccagatgttaactCggctccatcagctgcggcag	9	8	11	13	2	1	2	1	0	0	2	3	2	2	2	2	2	4	5	2	2	1	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr16:30977267C>T	uc002ead.1	+	8	2751	c.2065C>T	c.(2065-2067)CGG>TGG	p.R689W		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	689					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						GATGTTAACTCGGCTCCATCA	0.617													42	144					0	0	0	0	T	30977267	T	T	30977267	3	4	63	1	0	0	0	0	1	0	0	0	14195	875	31	1	2091	1	SETD1A	16	30977267	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08		30977267	59377486	85	12668											
ZNF267	10308	broad.mit.edu	37	chr16	31927606	31927606	+	Missense_Mutation	SNP	G	A	A																															gtcatacctcactacacatcGgagaagacatactggagaga																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr16:31927606G>A	uc002ecs.3	+	4	2245	c.2036G>A	c.(2035-2037)CGG>CAG	p.R679Q		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	679	C2H2-type 13.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						ACTACACATCGGAGAAGACAT	0.443													7	95					0	0	0	0	A	31927606	A	A	31927606	3	1	63	1	0	0	0	0	1	0	0	0	17873	1116	39	1	2050	1	ZNF267	16	31927606	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	950339	31927606	58427147	86	12669	27	2									
ZNF267	10308	broad.mit.edu	37	chr16	31927613	31927613	+	Missense_Mutation	SNP	A	T	T																															ctcactacacatcggagaagAcatactggagagagacccta																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr16:31927613A>T	uc002ecs.3	+	4	2252	c.2043A>T	c.(2041-2043)AGA>AGT	p.R681S		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	681	C2H2-type 13.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						ATCGGAGAAGACATACTGGAG	0.448													7	94					0	0	0	0	T	31927613	T	T	31927613	3	4	63	1	0	0	0	0	1	0	0	0	17873	272	10	5	2057	5	ZNF267	16	31927613	Missense_Mutation	SNP	A	TCGA-CN-5366-01A-01D-1434-08	7	31927613	58427140	87	12670	27	2									
DPEP2	64174	broad.mit.edu	37	chr16	68021883	68021883	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggacacgtcttccagcccctGagggaatctgtgtggccacc	7	8	12	14	1	2	1	0	1	2	0	3	3	3	3	5	3	1	0	5	3	1	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr16:68021883G>A	uc010cey.2	-	9	1242	c.1078C>T	c.(1078-1080)CAG>TAG	p.Q360*	DPEP2_uc002evd.3_Nonsense_Mutation_p.Q365*|DPEP2_uc002eve.2_Nonsense_Mutation_p.Q360*|DPEP2_uc002evf.2_RNA	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	dipeptidase 2 precursor	360					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TCCAGCCCCTGAGGGAATCTG	0.557													31	120					0	0	0	0	A	68021883	A	A	68021883	4	1	63	1	0	0	0	0	0	1	0	0	4736	1299	45	2	390	2	DPEP2	16	68021883	Nonsense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	36094270	68021883	22332870	88	12671											
PHLPP2	23035	broad.mit.edu	37	chr16	71710362	71710363	+	Frame_Shift_Ins	INS	-	A	A																															aactcactgttggaactggcINSatagagggtccgaagggaaa																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr16:71710362_71710363insA	uc002fax.2	-	8	1464_1465	c.1458_1459insT	c.(1456-1461)TATGCCfs	p.Y486fs	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Frame_Shift_Ins_p.Y486fs	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	486_487	LRR 11.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						TTGGAACTGGCATAGAGGGTCC	0.5													---	---	---								A	71710363	A	A	71710362	7	5	63	1	0	1	1	0	0	0	0	0	11910	710	25	0	2556	0	PHLPP2	16	71710362	Frame_Shift_Ins	INS	-	TCGA-CN-5366-01A-01D-1434-08	3688479	71710362	18644391	89	12672											
SPEM1	374768	broad.mit.edu	37	chr17	7324583	7324583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaaaacaggcatatggtccGagctgggcctaagggcctat	11	8	12	10	1	1	0	1	0	0	0	2	1	2	0	3	4	2	2	3	4	5	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:7324583G>A	uc002ggv.2	+	3	614	c.589G>A	c.(589-591)GAG>AAG	p.E197K	FGF11_uc010vtw.1_Intron	NM_199339	NP_955371	Q8N4L4	SPEM1_HUMAN	spermatid maturation 1	197					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|integral to membrane					0		Prostate(122;0.173)				CATATGGTCCGAGCTGGGCCT	0.637													5	95					0	0	0	0	A	7324583	A	A	7324583	3	1	63	1	0	0	0	0	1	0	0	0	15103	1059	37	1	599	1	SPEM1	17	7324583	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08		7324583	73870627	90	12673											
TP53	7157	broad.mit.edu	37	chr17	7578413	7578413	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtgggggcagcgcctcaCaacctccgtcatgtgctgtg	6	9	14	12	2	2	0	2	0	0	0	3	0	3	0	3	3	3	2	3	3	1	0			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:7578413C>T	uc002gim.2	-	5	711	c.517G>A	c.(517-519)GTG>ATG	p.V173M	TP53_uc002gig.1_Missense_Mutation_p.V173M|TP53_uc002gih.2_Missense_Mutation_p.V173M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V41M|TP53_uc010cng.1_Missense_Mutation_p.V41M|TP53_uc002gii.1_Missense_Mutation_p.V41M|TP53_uc010cnh.1_Missense_Mutation_p.V173M|TP53_uc010cni.1_Missense_Mutation_p.V173M|TP53_uc002gij.2_Missense_Mutation_p.V173M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V80M|TP53_uc002gio.2_Missense_Mutation_p.V41M|TP53_uc010vug.1_Missense_Mutation_p.V134M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(54)|p.V173M(40)|p.V173A(8)|p.V173V(8)|p.0?(7)|p.V173G(6)|p.V173fs*1(4)|p.V80L(2)|p.V173fs*59(2)|p.V41L(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.V173E(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.V80M(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.V41M(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			35	65					0	0	0	0	T	7578413	T	T	7578413	3	4	63	1	0	0	0	0	1	0	0	0	16448	478	17	4	781	4	TP53	17	7578413	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	253830	7578413	73616797	91	12674											
MYH13	8735	broad.mit.edu	37	chr17	10206726	10206726	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctacctggtaagtcatctcCttgactttgcgttcgtactt	6	16	7	12	2	2	1	1	1	1	0	4	1	2	1	3	1	3	3	3	1	3	7			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:10206726C>A	uc002gmk.1	-	38	5646	c.5556G>T	c.(5554-5556)AAG>AAT	p.K1852N		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1852	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						AAGTCATCTCCTTGACTTTGC	0.542													38	279					3.62531e-18	3.97441e-18	1	0	A	10206726	A	A	10206726	3	1	63	1	0	0	0	0	1	0	0	0	10085	680	24	4	276	4	MYH13	17	10206726	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	2628313	10206726	70988484	92	12675											
PIGS	94005	broad.mit.edu	37	chr17	26885585	26885585	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagtcaaagcggggattcacCcccaacattgcatagtaaag	14	7	10	10	1	2	0	2	0	0	0	2	2	2	1	2	2	3	2	2	2	5	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:26885585C>A	uc002hbo.2	-	8	1216	c.843G>T	c.(841-843)GGG>GGT	p.G281G	PIGS_uc002hbn.2_Silent_p.G273G|PIGS_uc010wap.1_Silent_p.G220G	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	281	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					GGGGATTCACCCCCAACATTG	0.398													9	23					7.48243e-07	7.91e-07	1	0	A	26885585	A	A	26885585	2	1	63	1	0	0	0	0	0	0	0	1	11953	610	22	4		4	PIGS	17	26885585	Silent	SNP	C	TCGA-CN-5366-01A-01D-1434-08	16678859	26885585	54309625	93	12676											
MYO18A	399687	broad.mit.edu	37	chr17	27414043	27414043	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccggagctgcctctgtagccGcttgttctgttccttctccc	2	14	9	16	2	3	0	0	0	3	0	5	1	4	1	5	1	3	5	5	1	1	5			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:27414043G>A	uc002hdt.1	-	38	5781	c.5623C>T	c.(5623-5625)CGG>TGG	p.R1875W	MYO18A_uc010wbc.1_Missense_Mutation_p.R1408W|MYO18A_uc002hds.2_Missense_Mutation_p.R1417W|MYO18A_uc010csa.1_Missense_Mutation_p.R1838W|MYO18A_uc002hdu.1_Missense_Mutation_p.R1875W	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1875	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CTCTGTAGCCGCTTGTTCTGT	0.612													18	92					0	0	0	0	A	27414043	A	A	27414043	3	1	63	1	0	0	0	0	1	0	0	0	10118	1086	38	1	561	1	MYO18A	17	27414043	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	528458	27414043	53781167	94	12677											
TMEM132E	124842	broad.mit.edu	37	chr17	32964713	32964713	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cggcatgtacgcgctgctggGcgtcttctgcctcgccatcc	3	10	12	16	5	2	0	0	0	2	0	4	0	3	0	3	2	3	4	3	2	1	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:32964713G>A	uc002hif.2	+	10	2745	c.2417G>A	c.(2416-2418)GGC>GAC	p.G806D		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	806	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GCGCTGCTGGGCGTCTTCTGC	0.637													19	120					0	0	0	0	A	32964713	A	A	32964713	3	1	63	1	0	0	0	0	1	0	0	0	16114	1203	42	4	2455	4	TMEM132E	17	32964713	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	5550670	32964713	48230497	95	12678											
PLEKHM1	9842	broad.mit.edu	37	chr17	43516996	43516996	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccttcatacaccccgtctGcgatctgcggagggcaagta	9	9	10	13	3	3	0	1	0	2	0	4	2	4	1	3	2	3	2	3	2	3	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:43516996G>C	uc002ija.2	-	11	3076	c.2906C>G	c.(2905-2907)GCA>GGA	p.A969G	PLEKHM1_uc010wjm.1_Missense_Mutation_p.A941G|PLEKHM1_uc002ijb.2_Missense_Mutation_p.A444G	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	969					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					CACCCCGTCTGCGATCTGCGG	0.582													26	69					0	0	0	0	C	43516996	C	C	43516996	3	2	63	1	0	0	0	0	1	0	0	0	12135	1319	46	4	272	4	PLEKHM1	17	43516996	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	10552283	43516996	37678214	96	12679											
NPEPPS	9520	broad.mit.edu	37	chr17	45695767	45695768	+	In_Frame_Ins	INS	-	TTG	TTG																															aaaccgaatcgaaagagtccINSttggcgctactcttttgcct																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr17:45695767_45695768insTTG	uc002ilr.3	+	20	2570_2571	c.2347_2348insTTG	c.(2347-2349)CTT>CTTGTT	p.783_784insV	NPEPPS_uc010wkt.1_In_Frame_Ins_p.779_780insV|NPEPPS_uc010wku.1_In_Frame_Ins_p.747_748insV|NPEPPS_uc010wkv.1_In_Frame_Ins_p.337_338insV|NPEPPS_uc002ils.1_In_Frame_Ins_p.216_217insV	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	783_784					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						CGAAAGAGTCCTTGGCGCTACT	0.391													---	---	---								TTG	45695768	TTG	TTG	45695767	7	5	63	1	0	1	1	0	0	0	0	0	10629	681	24	0	2425	0	NPEPPS	17	45695767	In_Frame_Ins	INS	-	TCGA-CN-5366-01A-01D-1434-08	2178771	45695767	35499443	97	12680											
SETBP1	26040	broad.mit.edu	37	chr18	42533185	42533185	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaatgacaagtgggacagtGacgtgagtgggagtaaaagg	14	6	17	4	2	0	3	0	3	0	0	0	6	0	5	0	3	0	1	0	3	4	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr18:42533185G>C	uc010dni.2	+	4	4176	c.3880G>C	c.(3880-3882)GAC>CAC	p.D1294H		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1294						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GTGGGACAGTGACGTGAGTGG	0.498									Schinzel-Giedion_syndrome				11	80					0	0	0	0	C	42533185	C	C	42533185	3	2	63	1	0	0	0	0	1	0	0	0	14194	1290	45	2	4083	2	SETBP1	18	42533185	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08		42533185	35544063	98	12681											
CDH7	1005	broad.mit.edu	37	chr18	63526222	63526222	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atacttgacatcaatgataaCgcccctgaatttgccatgga	13	11	7	10	1	1	3	1	3	0	0	1	4	1	4	3	1	3	0	3	1	4	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr18:63526222C>T	uc002ljz.2	+	9	1759	c.1434C>T	c.(1432-1434)AAC>AAT	p.N478N	CDH7_uc002lka.2_Silent_p.N478N|CDH7_uc002lkb.2_Silent_p.N478N	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	478	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TCAATGATAACGCCCCTGAAT	0.428													7	90					0	0	0	0	T	63526222	T	T	63526222	2	4	63	1	0	0	0	0	0	0	0	1	3130	535	19	1		1	CDH7	18	63526222	Silent	SNP	C	TCGA-CN-5366-01A-01D-1434-08	20993037	63526222	14551026	99	12682											
ZNF554	115196	broad.mit.edu	37	chr19	2834412	2834412	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagccttcaacaggatctcAtcgctgactcagcatcagag	13	8	8	12	1	4	2	4	1	1	1	6	3	4	3	1	1	3	2	1	1	2	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:2834412A>T	uc002lwm.2	+	5	1377	c.1179A>T	c.(1177-1179)TCA>TCT	p.S393S	ZNF554_uc002lwl.2_Silent_p.S342S	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	393	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGGATCTCATCGCTGACTC	0.532													17	81					0	0	0	0	T	2834412	T	T	2834412	2	4	63	1	0	0	0	0	0	0	0	1	18052	204	8	5		5	ZNF554	19	2834412	Silent	SNP	A	TCGA-CN-5366-01A-01D-1434-08		2834412	56294571	100	12683											
KANK3	256949	broad.mit.edu	37	chr19	8387792	8387792	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtggctgtctgggagccAgggggtgactcgctctggag	4	9	20	8	1	2	1	0	1	2	0	3	3	2	3	1	6	1	2	1	6	0	0			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:8387792A>T	uc010dwa.2	-	11	2463	c.2397T>A	c.(2395-2397)CCT>CCA	p.P799P	NDUFA7_uc002mjm.1_5'Flank	NM_198471	NP_940873	Q6NY19	KANK3_HUMAN	ankyrin repeat domain 47	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0						TCTGGGAGCCAGGGGGTGACT	0.592													3	50					0	0	0	0	T	8387792	T	T	8387792	2	4	63	1	0	0	0	0	0	0	0	1	8017	175	7	5		5	KANK3	19	8387792	Silent	SNP	A	TCGA-CN-5366-01A-01D-1434-08	5553380	8387792	50741191	101	12684											
PRKACA	5566	broad.mit.edu	37	chr19	14217672	14217672	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgtgccgagggtcttgattCgttcaaactgatccaagtgg	8	11	12	10	3	2	2	1	2	1	0	4	3	3	2	3	2	2	1	3	2	2	3	rs56085217		TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:14217672C>T	uc002myc.2	-	3	337	c.137G>A	c.(136-138)CGA>CAA	p.R46Q	PRKACA_uc002myb.2_Missense_Mutation_p.R38Q|PRKACA_uc010xnm.1_5'UTR|PRKACA_uc002myd.2_5'UTR	NM_002730	NP_002721	P17612	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit	46	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1						GGTCTTGATTCGTTCAAACTG	0.602													11	113					0	0	0	0	T	14217672	T	T	14217672	3	4	63	1	0	0	0	0	1	0	0	0	12559	884	31	1	950	1	PRKACA	19	14217672	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	5829880	14217672	44911311	102	12685											
MYO9B	4650	broad.mit.edu	37	chr19	17305984	17305984	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaggcctggccagttggagCggccgaccagcctggccctg	5	5	15	16	2	0	0	0	0	0	0	0	2	0	1	7	5	2	1	7	5	0	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:17305984C>T	uc010eak.2	+	22	3900	c.3748C>T	c.(3748-3750)CGG>TGG	p.R1250W	MYO9B_uc002nfi.2_Missense_Mutation_p.R1250W|MYO9B_uc002nfj.1_Missense_Mutation_p.R1250W|MYO9B_uc002nfl.1_5'Flank	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1250	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CCAGTTGGAGCGGCCGACCAG	0.677													9	21					0	0	0	0	T	17305984	T	T	17305984	3	4	63	1	0	0	0	0	1	0	0	0	10138	759	27	1	3830	1	MYO9B	19	17305984	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	3088312	17305984	41822999	103	12686											
ZNF493	284443	broad.mit.edu	37	chr19	21606315	21606315	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataccttactaggcataagcTaattcatactagagagaaac	17	10	6	8	0	1	2	1	0	0	2	1	3	1	2	1	1	5	2	1	1	8	8			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:21606315T>G	uc002npx.2	+	2	750	c.470T>G	c.(469-471)CTA>CGA	p.L157R	ZNF493_uc002npw.2_Missense_Mutation_p.L285R|ZNF493_uc002npy.2_Missense_Mutation_p.L157R	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	157	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGGCATAAGCTAATTCATACT	0.343													26	103					0	0	0	0	G	21606315	G	G	21606315	3	3	63	1	0	0	0	0	1	0	0	0	18011	1522	53	5	931	5	ZNF493	19	21606315	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	4300331	21606315	37522668	104	12687			1	18		2	2	25	N	T_A	9.30288e-05
ZNF493	284443	broad.mit.edu	37	chr19	21606339	21606339	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatactagagagaaaccctAtaaatgtgaacaatatggca	18	9	7	7	0	1	3	1	1	0	2	1	4	1	3	1	1	3	1	1	1	9	5			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:21606339A>G	uc002npx.2	+	2	774	c.494A>G	c.(493-495)TAT>TGT	p.Y165C	ZNF493_uc002npw.2_Missense_Mutation_p.Y293C|ZNF493_uc002npy.2_Missense_Mutation_p.Y165C	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	165	C2H2-type 6; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAGAAACCCTATAAATGTGAA	0.343													25	114					0	0	0	0	G	21606339	G	G	21606339	3	3	63	1	0	0	0	0	1	0	0	0	18011	449	16	5	955	5	ZNF493	19	21606339	Missense_Mutation	SNP	A	TCGA-CN-5366-01A-01D-1434-08	24	21606339	37522644	105	12688			1	18		2	2	25	N	T_A	9.30288e-05
ZNF429	353088	broad.mit.edu	37	chr19	21719595	21719595	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctactcaacccttactaaccAtaagagaattcatactggag	15	10	5	11	0	2	1	2	0	0	1	2	3	2	2	2	1	5	0	2	1	7	6			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:21719595A>G	uc002nqd.1	+	4	877	c.740A>G	c.(739-741)CAT>CGT	p.H247R	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	247	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTTACTAACCATAAGAGAATT	0.383													14	87					0	0	0	0	G	21719595	G	G	21719595	3	3	63	1	0	0	0	0	1	0	0	0	17969	217	8	5	754	5	ZNF429	19	21719595	Missense_Mutation	SNP	A	TCGA-CN-5366-01A-01D-1434-08	113256	21719595	37409388	106	12689											
ZNF100	163227	broad.mit.edu	37	chr19	21910043	21910043	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttatgtgtagtaagggttgaGgactggttaaaggctttgcc	9	14	14	4	0	0	1	0	1	0	0	0	2	0	2	1	4	1	5	1	4	5	6			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:21910043G>A	uc002nqi.2	-	5	1270	c.1071C>T	c.(1069-1071)TCC>TCT	p.S357S	ZNF100_uc002nqh.2_Silent_p.S293S	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	357	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAAGGGTTGAGGACTGGTTAA	0.398													19	179					0	0	0	0	A	21910043	A	A	21910043	2	1	63	1	0	0	0	0	0	0	0	1	17780	987	35	4		4	ZNF100	19	21910043	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	190448	21910043	37218940	107	12690											
PSG4	5672	broad.mit.edu	37	chr19	43708353	43708353	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactttgggtggctgggcttCaatcgtgacttgggcagttg	6	13	15	7	1	1	1	1	1	0	0	2	1	1	1	0	4	1	4	0	4	2	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:43708353C>T	uc002ovy.2	-	2	217	c.115G>A	c.(115-117)GAA>AAA	p.E39K	PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.E39K|PSG4_uc002ovz.2_Missense_Mutation_p.E39K	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	39	Ig-like V-type.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				GGCTGGGCTTCAATCGTGACT	0.458													45	385					0	0	0	0	T	43708353	T	T	43708353	3	4	63	1	0	0	0	0	1	0	0	0	12719	835	29	2	1164	2	PSG4	19	43708353	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	21798310	43708353	15420630	108	12691											
ZNF221	7638	broad.mit.edu	37	chr19	44471151	44471151	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttttgaaacatcagagactCcacagtggggaaaaaccttt	14	10	8	9	0	1	2	1	1	0	1	2	4	2	3	2	2	2	0	2	2	3	3	rs79157058	byFrequency	TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:44471151C>A	uc002oxx.2	+	6	1825	c.1497C>A	c.(1495-1497)CTC>CTA	p.L499L	ZNF221_uc010ejb.1_Silent_p.L499L|ZNF221_uc010xws.1_Silent_p.L499L	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	499	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				ATCAGAGACTCCACAGTGGGG	0.458													32	129					4.3181e-19	4.76924e-19	1	0	A	44471151	A	A	44471151	2	1	63	1	0	0	0	0	0	0	0	1	17842	842	30	2		2	ZNF221	19	44471151	Silent	SNP	C	TCGA-CN-5366-01A-01D-1434-08	762798	44471151	14657832	109	12692											
FPR2	2358	broad.mit.edu	37	chr19	52272530	52272531	+	Frame_Shift_Ins	INS	-	T	T																															cagagggattatccggtttgINStcattggctttagcttgccg																										TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:52272530_52272531insT	uc002pxr.2	+	2	664_665	c.619_620insT	c.(619-621)GTCfs	p.V207fs	FPR2_uc002pxs.3_Frame_Shift_Ins_p.V207fs|FPR2_uc010epf.2_Frame_Shift_Ins_p.V207fs	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	207	Helical; Name=5; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						TATCCGGTTTGTCATTGGCTTT	0.505													---	---	---								T	52272531	T	T	52272530	7	5	63	1	0	1	1	0	0	0	0	0	6073	1377	48	0	621	0	FPR2	19	52272530	Frame_Shift_Ins	INS	-	TCGA-CN-5366-01A-01D-1434-08	7801379	52272530	6856453	110	12693											
TMC4	147798	broad.mit.edu	37	chr19	54664984	54664984	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggcagccggggagcaggtgGagaagagggtaagctggtgg	9	4	23	5	1	0	2	0	0	0	2	0	4	0	3	1	8	3	4	1	8	2	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:54664984G>A	uc010erf.2	-	12	1850	c.1718C>T	c.(1717-1719)TCC>TTC	p.S573F	LENG1_uc002qdm.2_5'Flank|TMC4_uc002qdn.2_Missense_Mutation_p.S287F|TMC4_uc002qdo.2_Missense_Mutation_p.S567F	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	573	Cytoplasmic (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGAGCAGGTGGAGAAGAGGGT	0.522													6	28					0	0	0	0	A	54664984	A	A	54664984	3	1	63	1	0	0	0	0	1	0	0	0	16053	1174	41	2	436	2	TMC4	19	54664984	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	2392454	54664984	4463999	111	12694											
LILRA3	11026	broad.mit.edu	37	chr19	54803127	54803127	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttgggctcacggggcccaCggagaagatggcccgggatg	8	5	17	11	3	1	2	1	0	0	2	1	4	1	3	2	6	0	1	2	6	1	1			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr19:54803127C>T	uc002qfd.2	-	4	615	c.550G>A	c.(550-552)GTG>ATG	p.V184M	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	184	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACGGGGCCCACGGAGAAGATG	0.567													53	55					0	0	0	0	T	54803127	T	T	54803127	3	4	63	1	0	0	0	0	1	0	0	0	8827	536	19	1	785	1	LILRA3	19	54803127	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	138143	54803127	4325856	112	12695											
CST4	1472	broad.mit.edu	37	chr20	23667796	23667796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggacttggtacatatggtgcGgcccacctctacgtcgaaga	9	9	12	11	3	1	1	0	0	1	1	2	3	1	2	2	4	3	1	2	4	4	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr20:23667796G>A	uc002wto.1	-	2	327	c.271C>T	c.(271-273)CGC>TGC	p.R91C		NM_001899	NP_001890	P01036	CYTS_HUMAN	cystatin S precursor	91						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					CATATGGTGCGGCCCACCTCT	0.572													27	219					0	0	0	0	A	23667796	A	A	23667796	3	1	63	1	0	0	0	0	1	0	0	0	3991	1116	39	1	162	1	CST4	20	23667796	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08		23667796	39357724	113	12696											
C22orf36	388886	broad.mit.edu	37	chr22	24982183	24982183	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgggtgaggcggggcaGcgcccacaggctgggcagca	7	3	20	11	2	0	1	0	1	0	0	0	2	0	1	1	6	3	5	1	6	0	0			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr22:24982183G>A	uc003aaq.2	-	4	648	c.619C>T	c.(619-621)CTG>TTG	p.L207L	GGT1_uc003aan.1_Intron|C22orf36_uc003aao.2_RNA|C22orf36_uc003aap.2_RNA	NM_207644	NP_997527	Q2VPJ9	LRC6X_HUMAN	hypothetical protein LOC388886	207	LRR 2.										0						AGGCGGGGCAGCGCCCACAGG	0.657													29	82					0	0	0	0	A	24982183	A	A	24982183	2	1	63	1	0	0	0	0	0	0	0	1	2156	962	34	4		4	C22orf36	22	24982183	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08		24982183	26322383	114	12697											
APOBEC3C	27350	broad.mit.edu	37	chr22	39411612	39411612	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccttcagaaacccgatgaaGgcaatgtatccaggcacatt	13	8	9	11	1	1	2	1	1	0	1	2	3	2	2	3	2	1	3	3	2	4	3			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chr22:39411612G>A	uc003awr.2	+	2	133	c.30G>A	c.(28-30)AAG>AAA	p.K10K	APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_014508	NP_055323	Q9NRW3	ABC3C_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	10					DNA demethylation|interspecies interaction between organisms|negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|protein binding|zinc ion binding				0	Melanoma(58;0.04)					ACCCGATGAAGGCAATGTATC	0.522													19	157					0	0	0	0	A	39411612	A	A	39411612	2	1	63	1	0	0	0	0	0	0	0	1	791	991	35	4		4	APOBEC3C	22	39411612	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	14429429	39411612	11892954	115	12698											
CNKSR2	22866	broad.mit.edu	37	chrX	21609140	21609140	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agagcatttccaccctttagGtcctatagcaggcaagagca	12	9	9	11	0	0	2	0	0	0	2	2	2	2	2	3	2	3	4	3	2	4	5			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrX:21609140G>T	uc004czx.1	+	15	1694	c.1658G>T	c.(1657-1659)GGT>GTT	p.G553V	CNKSR2_uc004czw.2_Missense_Mutation_p.G553V|CNKSR2_uc011mjn.1_Missense_Mutation_p.G504V|CNKSR2_uc011mjo.1_Missense_Mutation_p.G523V|CNKSR2_uc004czy.2_Missense_Mutation_p.G145V	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	553					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						CACCCTTTAGGTCCTATAGCA	0.383													51	102					9.16383e-17	9.89962e-17	1	0	T	21609140	T	T	21609140	3	4	63	1	0	0	0	0	1	0	0	0	3622	1275	44	4	1716	4	CNKSR2	23	21609140	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08		21609140	133661420	116	12699											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29417342	29417342	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcttataagagaagtcaGagaagatgacattggaaatt	16	11	10	4	0	2	4	1	1	1	3	2	7	2	5	0	1	1	1	0	1	5	4			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrX:29417342G>T	uc004dby.2	+	5	1128	c.620G>T	c.(619-621)AGA>ATA	p.R207I		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	207	Ig-like C2-type 2.|Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						AGAGAAGTCAGAGAAGATGAC	0.338													28	42					1.33986e-20	1.50227e-20	1	0	T	29417342	T	T	29417342	3	4	63	1	0	0	0	0	1	0	0	0	7700	942	33	2	634	2	IL1RAPL1	23	29417342	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08	7808202	29417342	125853218	117	12700											
KIAA2022	340533	broad.mit.edu	37	chrX	73962241	73962241	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttttaaatttgattttattGagcactttcctctctggccc	7	19	5	10	0	1	2	0	2	1	0	3	2	2	2	2	1	1	1	2	1	3	7			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrX:73962241G>C	uc004eby.2	-	3	2768	c.2151C>G	c.(2149-2151)CTC>CTG	p.L717L		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	717					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TGATTTTATTGAGCACTTTCC	0.418													4	103					0	0	0	0	C	73962241	C	C	73962241	2	2	63	1	0	0	0	0	0	0	0	1	8308	1277	45	2		2	KIAA2022	23	73962241	Silent	SNP	G	TCGA-CN-5366-01A-01D-1434-08	44544899	73962241	81308319	118	12701											
NRK	203447	broad.mit.edu	37	chrX	105153047	105153047	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaaggcacctccacgactaCggagggcagccagggtgctc	9	6	13	13	2	0	0	0	0	0	0	2	2	1	1	3	4	3	3	3	4	2	2			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrX:105153047C>T	uc004emd.2	+	13	1717	c.1414C>T	c.(1414-1416)CGG>TGG	p.R472W	NRK_uc010npc.1_Missense_Mutation_p.R140W	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	472	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TCCACGACTACGGAGGGCAGC	0.557										HNSCC(51;0.14)			10	26					0	0	0	0	T	105153047	T	T	105153047	3	4	63	1	0	0	0	0	1	0	0	0	10709	527	19	1	1464	1	NRK	23	105153047	Missense_Mutation	SNP	C	TCGA-CN-5366-01A-01D-1434-08	31190806	105153047	50117513	119	12702											
CLDN2	9075	broad.mit.edu	37	chrX	106171511	106171511	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catcctaggccttctggggcTtttgggcacactggttgcca	5	12	12	12	0	1	0	0	0	1	0	2	0	2	0	3	5	1	3	3	5	1	5			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrX:106171511T>C	uc004emq.1	+	2	572	c.53T>C	c.(52-54)CTT>CCT	p.L18P	MORC4_uc004emp.3_Intron|CLDN2_uc004emt.1_Missense_Mutation_p.L18P	NM_020384	NP_065117	P57739	CLD2_HUMAN	claudin 2	18	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						CTTCTGGGGCTTTTGGGCACA	0.562													3	98					0	0	0	0	C	106171511	C	C	106171511	3	2	63	1	0	0	0	0	1	0	0	0	3496	1609	56	5	55	5	CLDN2	23	106171511	Missense_Mutation	SNP	T	TCGA-CN-5366-01A-01D-1434-08	1018464	106171511	49099049	120	12703											
DDX3Y	8653	broad.mit.edu	37	chrY	15025642	15025642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttggcagtttagcgatattGacatgggagaaattatcatg	12	13	11	5	1	1	2	1	1	0	1	1	4	1	2	0	2	1	2	0	2	4	6			TCGA-CN-5366-01A-01D-1434-08	TCGA-CN-5366-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	161342fd-4cfa-4fc8-9708-7bb815b137c6	a7c5797e-de41-4381-9ce7-8277a48494f3	g.chrY:15025642G>A	uc004fsu.1	+	8	859	c.550G>A	c.(550-552)GAC>AAC	p.D184N	DDX3Y_uc010nwv.1_Missense_Mutation_p.D184N|DDX3Y_uc011naq.1_Missense_Mutation_p.D184N|DDX3Y_uc004fsv.2_Missense_Mutation_p.D184N|DDX3Y_uc010nww.1_5'UTR|DDX3Y_uc011nar.1_Missense_Mutation_p.D181N	NM_001122665	NP_001116137	O15523	DDX3Y_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3,	184	Q motif.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|RNA binding				0						TAGCGATATTGACATGGGAGA	0.348													16	83					0	0	0	0	A	15025642	A	A	15025642	3	1	63	1	0	0	0	0	1	0	0	0	4376	1290	45	2	576	2	DDX3Y	24	15025642	Missense_Mutation	SNP	G	TCGA-CN-5366-01A-01D-1434-08		15025642	44347924	121	12704											
C1orf187	374946	broad.mit.edu	37	chr1	11766452	11766452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaatcacattgacctcccagGcccagcgctgtggacgcctc	8	7	10	16	2	1	1	1	1	0	0	3	3	2	2	4	2	1	1	4	2	1	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr1:11766452G>A	uc001asr.1	+	2	277	c.137G>A	c.(136-138)GGC>GAC	p.G46D		NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor	46					axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		GACCTCCCAGGCCCAGCGCTG	0.716													9	27					0	0	0	0	A	11766452	A	A	11766452	3	1	64	1	0	0	0	0	1	0	0	0	2030	1203	42	4	139	4	C1orf187	1	11766452	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08		11766452	237484169	1	12705											
EFHD2	79180	broad.mit.edu	37	chr1	15752368	15752368	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctctttttgcatctgcaggTatgatgccgggcgggacggc	5	12	14	10	3	2	1	0	1	2	0	3	2	2	2	1	4	3	3	1	4	1	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr1:15752368T>G	uc001awh.2	+	2	387	c.310T>G	c.(310-312)TAT>GAT	p.Y104D		NM_024329	NP_077305	Q96C19	EFHD2_HUMAN	EF-hand domain family, member D2	104	EF-hand 1.					membrane raft					0		Renal(390;0.00145)|Breast(348;0.00173)|Colorectal(325;0.00215)|all_lung(284;0.00366)|Lung NSC(340;0.00395)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)|Hepatocellular(190;0.152)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.59e-07)|COAD - Colon adenocarcinoma(227;3.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000119)|KIRC - Kidney renal clear cell carcinoma(229;0.00251)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		CATCTGCAGGTATGATGCCGG	0.557													10	96					0	0	0	0	G	15752368	G	G	15752368	3	3	64	1	0	0	0	0	1	0	0	0	4971	1652	57	5	316	5	EFHD2	1	15752368	Missense_Mutation	SNP	T	TCGA-CN-5367-01A-01D-1434-08	3985916	15752368	233498253	2	12706											
EIF2C4	192670	broad.mit.edu	37	chr1	36316594	36316594	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctctattccagcccctgcatAttatgcccggcttgtagcat	7	13	7	14	1	1	0	0	0	1	0	2	0	2	0	4	1	4	4	4	1	4	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr1:36316594A>G	uc001bzj.1	+	17	2607	c.2417A>G	c.(2416-2418)TAT>TGT	p.Y806C		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	806	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCCCCTGCATATTATGCCCGG	0.453													4	33					0	0	0	0	G	36316594	G	G	36316594	3	3	64	1	0	0	0	0	1	0	0	0	5030	449	16	5	2483	5	EIF2C4	1	36316594	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	20564226	36316594	212934027	3	12707											
COL8A2	1296	broad.mit.edu	37	chr1	36564363	36564363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtggggcctatcagcccagGggggccccgggtccctggct	4	6	17	14	1	1	0	1	0	0	0	2	0	2	0	5	7	1	1	5	7	1	1	rs372280		TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr1:36564363G>A	uc001bzv.1	-	2	926	c.919C>T	c.(919-921)CCT>TCT	p.P307S	COL8A2_uc001bzw.1_Missense_Mutation_p.P242S	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	307	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				ATCAGCCCAGGGGGGCCCCGG	0.706													25	32					0	0	0	0	A	36564363	A	A	36564363	3	1	64	1	0	0	0	0	1	0	0	0	3721	1232	43	4	1196	4	COL8A2	1	36564363	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	247769	36564363	212686258	4	12708											
GLMN	11146	broad.mit.edu	37	chr1	92752126	92752126	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaattgtgctgtcagcaaaGggcatttcaagcttttgaaa	13	12	10	6	0	2	2	2	1	0	1	2	2	2	2	0	1	3	4	0	1	4	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr1:92752126G>T	uc001dor.2	-	7	771	c.656C>A	c.(655-657)CCT>CAT	p.P219H	GLMN_uc009wdg.2_RNA|GLMN_uc001dos.2_Missense_Mutation_p.P219H	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	219				P->A: Loss of interaction with FKBP12 and FKBP59.	muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		TGTCAGCAAAGGGCATTTCAA	0.333									Multiple_Glomus_Tumors_(of_the_Skin)_Familial				4	86					0.00024832	0.00026384	1	0	T	92752126	T	T	92752126	3	4	64	1	0	0	0	0	1	0	0	0	6485	1000	35	4	1180	4	GLMN	1	92752126	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	56187763	92752126	156498495	5	12709											
ITGA10	8515	broad.mit.edu	37	chr1	145535818	145535818	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcagagggactgtaggcggcGaggccaagaggcagtctgtc	9	6	17	9	2	2	2	1	0	1	2	3	4	2	3	1	5	0	2	1	5	2	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr1:145535818G>A	uc001eoa.2	+	16	2082	c.2006G>A	c.(2005-2007)CGA>CAA	p.R669Q	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.R538Q|ITGA10_uc009wiw.2_Missense_Mutation_p.R526Q|ITGA10_uc010oyw.1_Missense_Mutation_p.R614Q	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	669	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGTAGGCGGCGAGGCCAAGAG	0.577													25	139					0	0	0	0	A	145535818	A	A	145535818	3	1	64	1	0	0	0	0	1	0	0	0	7912	1058	37	1	2068	1	ITGA10	1	145535818	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	52783692	145535818	103714803	6	12710											
HRNR	388697	broad.mit.edu	37	chr1	152193084	152193084	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagaagtctggcctgagcCagactcataatggccacggc	10	6	12	13	1	2	3	1	1	1	2	2	3	2	3	4	3	1	0	4	3	2	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr1:152193084C>G	uc001ezt.1	-	3	1097	c.1021G>C	c.(1021-1023)GGC>CGC	p.G341R		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	341	3.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCCTGAGCCAGACTCATAA	0.577													11	124					0	0	0	0	G	152193084	G	G	152193084	3	3	64	1	0	0	0	0	1	0	0	0	7398	594	21	4	7535	4	HRNR	1	152193084	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	6657266	152193084	97057537	7	12711											
PEAR1	375033	broad.mit.edu	37	chr1	156876577	156876577	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgtacccctggctactaTggccctgcctgccagttccg	4	10	9	18	1	0	0	0	0	0	0	1	0	1	0	7	2	4	3	7	2	3	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr1:156876577T>A	uc001fqj.1	+	6	665	c.549T>A	c.(547-549)TAT>TAA	p.Y183*	PEAR1_uc009wsl.1_Intron|PEAR1_uc001fqk.1_5'UTR	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	183						integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTGGCTACTATGGCCCTGCCT	0.632													7	76					0	0	0	0	A	156876577	A	A	156876577	4	1	64	1	0	0	0	0	0	1	0	0	11766	1471	51	5	567	5	PEAR1	1	156876577	Nonsense_Mutation	SNP	T	TCGA-CN-5367-01A-01D-1434-08	4683493	156876577	92374044	8	12712											
SLC9A11	284525	broad.mit.edu	37	chr1	173552688	173552688	+	Frame_Shift_Del	DEL	A	-	-																															ctgttgccccgaaaatttccAaaaaaaattgatgcgatgct																										TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr1:173552688delA	uc001giz.2	-	6	1020	c.597delT	c.(595-597)TTTfs	p.F199fs	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	199	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						GAAAATTTCCAAAAAAAATTG	0.279													---	---	---								-	173552688	-	-	173552688	7	5	64	1	0	1	0	1	0	0	0	0	14775	127	5	0	2869	0	SLC9A11	1	173552688	Frame_Shift_Del	DEL	A	TCGA-CN-5367-01A-01D-1434-08	16676111	173552688	75697933	9	12713											
KIAA1383	54627	broad.mit.edu	37	chr1	232942446	232942446	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacctgtgacaagtcctgcTcatatacatcctcacctagc	11	10	5	15	0	2	1	2	1	0	0	4	1	4	1	4	0	4	1	4	0	5	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr1:232942446T>C	uc001hvh.2	+	1	1809	c.1677T>C	c.(1675-1677)GCT>GCC	p.A559A		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	417										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				CAAGTCCTGCTCATATACATC	0.413													3	77					0	0	0	0	C	232942446	C	C	232942446	2	2	64	1	0	0	0	0	0	0	0	1	8267	1538	54	5		5	KIAA1383	1	232942446	Silent	SNP	T	TCGA-CN-5367-01A-01D-1434-08	59389758	232942446	16308175	10	12714											
ZNF513	130557	broad.mit.edu	37	chr2	27600905	27600905	+	Frame_Shift_Del	DEL	T	-	-																															caccactgtgtgtcttcatgTgccgggccaggtggttggga																										TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr2:27600905delT	uc002rkk.2	-	4	1333	c.1133delA	c.(1132-1134)CACfs	p.H378fs	ZNF513_uc002rkj.2_Frame_Shift_Del_p.H316fs	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	378	C2H2-type 4.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTCTTCATGTGCCGGGCCAG	0.622													---	---	---								-	27600905	-	-	27600905	7	5	64	1	0	1	0	1	0	0	0	0	18025	1696	59	0	496	0	ZNF513	2	27600905	Frame_Shift_Del	DEL	T	TCGA-CN-5367-01A-01D-1434-08		27600905	215598468	11	12715											
ALMS1	7840	broad.mit.edu	37	chr2	73678468	73678468	+	Frame_Shift_Del	DEL	A	-	-																															cattgtttctggacctactgAaaaaaagactgacataccag																										TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr2:73678468delA	uc002sje.1	+	10	4928	c.4817delA	c.(4816-4818)GAAfs	p.E1606fs	ALMS1_uc002sjf.1_Frame_Shift_Del_p.E1562fs|ALMS1_uc002sjg.2_Frame_Shift_Del_p.E992fs|ALMS1_uc002sjh.1_Frame_Shift_Del_p.E992fs	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1604	23.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GGACCTACTGAAAAAAAGACT	0.453													---	---	---								-	73678468	-	-	73678468	7	5	64	1	0	1	0	1	0	0	0	0	535	246	9	0	4841	0	ALMS1	2	73678468	Frame_Shift_Del	DEL	A	TCGA-CN-5367-01A-01D-1434-08	46077563	73678468	169520905	12	12716											
ERCC3	2071	broad.mit.edu	37	chr2	128046972	128046972	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcttcttcatccttgtccaTttgctcatagaagtcaaaca	10	16	4	11	0	5	1	3	0	2	1	7	1	7	1	2	0	2	1	2	0	3	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr2:128046972T>C	uc002toh.1	-	6	858	c.763A>G	c.(763-765)ATG>GTG	p.M255V	ERCC3_uc002toe.1_Missense_Mutation_p.M10V|ERCC3_uc002tof.1_Missense_Mutation_p.M191V|ERCC3_uc002tog.1_Missense_Mutation_p.M191V|ERCC3_uc010flx.1_Missense_Mutation_p.M10V|ERCC3_uc010yzh.1_RNA	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	255					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TCCTTGTCCATTTGCTCATAG	0.478			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				16	60					0	0	0	0	C	128046972	C	C	128046972	3	2	64	1	0	0	0	0	1	0	0	0	5238	1493	52	5	1625	5	ERCC3	2	128046972	Missense_Mutation	SNP	T	TCGA-CN-5367-01A-01D-1434-08	54368504	128046972	115152401	13	12717											
NCKAP5	344148	broad.mit.edu	37	chr2	133538710	133538710	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgatagagctgccgatgAgacaggagccctgagaactg	12	7	13	9	1	0	4	0	3	0	3	0	8	0	5	2	1	5	1	2	1	3	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr2:133538710A>G	uc002ttp.2	-	15	5338	c.4964T>C	c.(4963-4965)CTC>CCC	p.L1655P	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1655							protein binding				0						GCTGCCGATGAGACAGGAGCC	0.458													7	41					0	0	0	0	G	133538710	G	G	133538710	3	3	64	1	0	0	0	0	1	0	0	0	10277	304	11	5	789	5	NCKAP5	2	133538710	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	5491738	133538710	109660663	14	12718											
ITGB6	3694	broad.mit.edu	37	chr2	161052924	161052924	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgccaactccagatggatgaGtaaaattctaaaaaagaaaa	20	7	7	7	1	1	3	0	1	1	2	2	4	2	4	2	1	1	1	2	1	8	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr2:161052924G>A	uc002ubh.2	-	3	165	c.149C>T	c.(148-150)ACT>ATT	p.T50I	ITGB6_uc010fow.1_RNA|ITGB6_uc010fou.2_Missense_Mutation_p.T50I|ITGB6_uc010zcq.1_Missense_Mutation_p.T8I|ITGB6_uc010fov.1_Missense_Mutation_p.T50I	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	50	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						AGATGGATGAGTAAAATTCTA	0.333													55	142					0	0	0	0	A	161052924	A	A	161052924	3	1	64	1	0	0	0	0	1	0	0	0	7938	1029	36	4	2269	4	ITGB6	2	161052924	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	27514214	161052924	82146449	15	12719											
ITGA6	3655	broad.mit.edu	37	chr2	173352098	173352098	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaatcccacaaaagatggcGatgacgcccatgaggctaaa	15	5	11	10	2	0	3	0	2	0	1	1	5	1	4	2	3	0	1	2	3	5	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr2:173352098G>A	uc002uhp.1	+	15	2280	c.2077G>A	c.(2077-2079)GAT>AAT	p.D693N	ITGA6_uc010zdy.1_Missense_Mutation_p.D574N|ITGA6_uc002uho.1_Missense_Mutation_p.D693N|ITGA6_uc010fqm.1_Missense_Mutation_p.D339N	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	732	Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			AAAAGATGGCGATGACGCCCA	0.418													28	62					0	0	0	0	A	173352098	A	A	173352098	3	1	64	1	0	0	0	0	1	0	0	0	7919	1058	37	1	2135	1	ITGA6	2	173352098	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	12299174	173352098	69847275	16	12720											
TTN	7273	broad.mit.edu	37	chr2	179582331	179582331	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atactgccctatgtggctctGgtcagtttgtaaaatctgaa	10	14	9	8	0	3	1	1	1	2	0	3	1	3	1	1	2	2	3	1	2	5	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr2:179582331G>T	uc010zfg.1	-	84	21762	c.21538C>A	c.(21538-21540)CAG>AAG	p.Q7180K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.Q3841K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8107							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTGGCTCTGGTCAGTTTGT	0.423													11	33					4.68919e-08	5.16148e-08	1	0	T	179582331	T	T	179582331	3	4	64	1	0	0	0	0	1	0	0	0	16803	1357	47	4	79363	4	TTN	2	179582331	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	6230233	179582331	63617042	17	12721											
ZC3H15	55854	broad.mit.edu	37	chr2	187366146	187366146	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcaagagatgaagaacttGaaaaaggtaatttttttaaa	19	12	8	2	0	0	4	0	2	0	2	0	5	0	4	0	1	2	2	0	1	8	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr2:187366146G>C	uc002upo.2	+	4	661	c.436G>C	c.(436-438)GAA>CAA	p.E146Q		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	146						cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			TGAAGAACTTGAAAAAGGTAA	0.299													4	82					0	0	0	0	C	187366146	C	C	187366146	3	2	64	1	0	0	0	0	1	0	0	0	17634	1291	45	2	450	2	ZC3H15	2	187366146	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	7783815	187366146	55833227	18	12722											
PAX3	5077	broad.mit.edu	37	chr2	223161786	223161786	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagacgcagccgtgggacaCgcgcagctggcgcgagatga	9	3	18	11	6	0	3	0	1	0	2	0	6	0	4	1	3	2	3	1	3	0	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr2:223161786C>T	uc010fwo.2	-	2	598	c.232G>A	c.(232-234)GTG>ATG	p.V78M	PAX3_uc002vmt.1_Missense_Mutation_p.V78M|PAX3_uc002vmy.1_Missense_Mutation_p.V78M|PAX3_uc002vmv.1_Missense_Mutation_p.V78M|PAX3_uc002vmw.1_Missense_Mutation_p.V78M|PAX3_uc002vmx.1_Missense_Mutation_p.V78M|PAX3_uc002vmz.1_Missense_Mutation_p.V78M|PAX3_uc002vna.1_Missense_Mutation_p.V78M|CCDC140_uc002vnb.1_5'Flank	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	78	Paired.		V -> M (in WS1).		apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCGTGGGACACGCGCAGCTGG	0.652			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						3	36					0	0	0	0	T	223161786	T	T	223161786	3	4	64	1	0	0	0	0	1	0	0	0	11534	536	19	1	1450	1	PAX3	2	223161786	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	35795640	223161786	20037587	19	12723											
GRM2	2912	broad.mit.edu	37	chr3	51746779	51746779	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggccgtgccatgagccgCgcggcctttgagggtgtggt	3	9	19	10	4	0	2	0	2	0	0	0	2	0	2	4	4	2	0	4	4	0	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr3:51746779C>T	uc010hlv.2	+	3	980	c.741C>T	c.(739-741)CGC>CGT	p.R247R	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	247	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CCATGAGCCGCGCGGCCTTTG	0.647													3	37					0	0	0	0	T	51746779	T	T	51746779	2	4	64	1	0	0	0	0	0	0	0	1	6836	755	27	1		1	GRM2	3	51746779	Silent	SNP	C	TCGA-CN-5367-01A-01D-1434-08		51746779	146275651	20	12724											
SUCLG2	8801	broad.mit.edu	37	chr3	67546294	67546294	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaccacctccaagatccaaGaagttggctggcttcccacc	11	7	7	16	0	0	2	0	0	0	2	3	2	3	2	6	2	0	3	6	2	3	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr3:67546294G>T	uc003dna.3	-	9	1018	c.990C>A	c.(988-990)TTC>TTA	p.F330L	SUCLG2_uc010hob.2_Intron	NM_003848	NP_003839	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming beta subunit	330					succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|skin(1)	2		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	CAAGATCCAAGAAGTTGGCTG	0.443													17	31					1.99824e-07	2.18379e-07	1	0	T	67546294	T	T	67546294	3	4	64	1	0	0	0	0	1	0	0	0	15431	933	33	2	464	2	SUCLG2	3	67546294	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	15799515	67546294	130476136	21	12725											
ZNF654	55279	broad.mit.edu	37	chr3	88189025	88189025	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaactgtgtgccatccaaaaGacatatatgccacagatcaa	16	8	7	10	0	1	2	1	0	0	2	2	3	2	2	3	0	3	0	3	0	6	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr3:88189025G>C	uc003dqv.2	+	1	764	c.565G>C	c.(565-567)GAC>CAC	p.D189H	CGGBP1_uc003dqu.2_Intron	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		CCATCCAAAAGACATATATGC	0.284													6	13					0	0	0	0	C	88189025	C	C	88189025	3	2	64	1	0	0	0	0	1	0	0	0	18134	942	33	2	567	2	ZNF654	3	88189025	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	20642731	88189025	109833405	22	12726											
OR5H15	403274	broad.mit.edu	37	chr3	97888223	97888223	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttctcttcacagtcttagAaaagaaatctgataagggtg	13	13	9	6	0	4	3	1	1	3	2	5	3	4	3	0	1	0	1	0	1	5	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr3:97888223A>T	uc011bgu.1	+	1	680	c.680A>T	c.(679-681)GAA>GTA	p.E227V		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ACAGTCTTAGAAAAGAAATCT	0.358													5	96					0	0	0	0	T	97888223	T	T	97888223	3	4	64	1	0	0	0	0	1	0	0	0	11215	246	9	5	682	5	OR5H15	3	97888223	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	9699198	97888223	100134207	23	12727											
SLC9A10	285335	broad.mit.edu	37	chr3	111918181	111918181	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccttaccttattaattccaGcaccttcagttttactaata	11	16	3	11	0	1	0	1	0	0	0	2	0	2	0	4	0	3	2	4	0	6	9			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr3:111918181G>A	uc003dyu.2	-	20	2732	c.2510C>T	c.(2509-2511)GCT>GTT	p.A837V	SLC9A10_uc011bhu.1_Missense_Mutation_p.A100V|SLC9A10_uc010hqc.2_Missense_Mutation_p.A789V	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	837					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						ATTAATTCCAGCACCTTCAGT	0.303													3	92					0	0	0	0	A	111918181	A	A	111918181	3	1	64	1	0	0	0	0	1	0	0	0	14774	971	34	4	1063	4	SLC9A10	3	111918181	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	14029958	111918181	86104249	24	12728											
POLQ	10721	broad.mit.edu	37	chr3	121200622	121200622	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taactatgctatgaagagtcGgctcctgagaatctggatct	11	12	10	8	1	2	3	0	2	2	2	4	5	3	4	1	2	2	2	1	2	5	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr3:121200622G>A	uc003eee.3	-	19	6137	c.6008C>T	c.(6007-6009)CCG>CTG	p.P2003L	POLQ_uc003eed.2_Missense_Mutation_p.P1175L	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2003					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		ATGAAGAGTCGGCTCCTGAGA	0.438								DNA_polymerases_(catalytic_subunits)					16	116					0	0	0	0	A	121200622	A	A	121200622	3	1	64	1	0	0	0	0	1	0	0	0	12263	1116	39	1	1812	1	POLQ	3	121200622	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	9282441	121200622	76821808	25	12729											
TF	7018	broad.mit.edu	37	chr3	133486976	133486976	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgtgtgaacccaacaacaaAgagggatactacggctacac	15	6	9	11	1	0	2	0	1	0	1	0	3	0	3	1	2	6	1	1	2	7	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr3:133486976A>G	uc003epu.1	+	18	3318	c.1590A>G	c.(1588-1590)AAA>AAG	p.K530K	TF_uc011blt.1_Silent_p.K403K|TF_uc003epw.1_Intron|TF_uc003epv.1_Silent_p.K530K	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	530	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	CCAACAACAAAGAGGGATACT	0.443													14	85					0	0	0	0	G	133486976	G	G	133486976	2	3	64	1	0	0	0	0	0	0	0	1	15851	69	3	5		5	TF	3	133486976	Silent	SNP	A	TCGA-CN-5367-01A-01D-1434-08	12286354	133486976	64535454	26	12730											
MCCC1	56922	broad.mit.edu	37	chr3	182759449	182759449	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaggcatgaagttattgctAggatcttctgcatatattct	11	15	8	7	0	3	1	0	1	3	0	3	2	3	2	0	2	2	4	0	2	5	7			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr3:182759449A>C	uc003fle.2	-	11	1310	c.1173T>G	c.(1171-1173)CCT>CCG	p.P391P	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Silent_p.P274P|MCCC1_uc003flg.2_Silent_p.P282P|MCCC1_uc011bqp.1_Silent_p.P344P	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	391	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	AGTTATTGCTAGGATCTTCTG	0.488													12	206					0	0	0	0	C	182759449	C	C	182759449	2	2	64	1	0	0	0	0	0	0	0	1	9427	407	15	5		5	MCCC1	3	182759449	Silent	SNP	A	TCGA-CN-5367-01A-01D-1434-08	49272473	182759449	15262981	27	12731											
HTR3C	170572	broad.mit.edu	37	chr3	183773130	183773130	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagctgctgacatcattcCtgtggatggatttggtaagg	8	13	12	8	0	1	1	1	1	0	0	3	3	3	3	2	4	2	3	2	4	1	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr3:183773130C>G	uc003fmk.2	+	3	299	c.265C>G	c.(265-267)CTG>GTG	p.L89V		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine receptor 3 subunit C	89	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GACATCATTCCTGTGGATGGA	0.403													23	105					0	0	0	0	G	183773130	G	G	183773130	3	3	64	1	0	0	0	0	1	0	0	0	7485	680	24	4	275	4	HTR3C	3	183773130	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	1013681	183773130	14249300	28	12732											
TBC1D14	57533	broad.mit.edu	37	chr4	6925212	6925212	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccttcagaacctgcaacaCgtcaatctcaaggcgccccg	10	6	7	18	3	3	1	3	0	1	1	4	1	3	1	5	1	3	1	5	1	4	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr4:6925212C>T	uc011bwg.1	+	2	175	c.96C>T	c.(94-96)CAC>CAT	p.H32H	TBC1D14_uc003gjs.3_Silent_p.H32H	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	32						intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						ACCTGCAACACGTCAATCTCA	0.562													9	108					0	0	0	0	T	6925212	T	T	6925212	2	4	64	1	0	0	0	0	0	0	0	1	15669	535	19	1		1	TBC1D14	4	6925212	Silent	SNP	C	TCGA-CN-5367-01A-01D-1434-08		6925212	184229064	29	12733											
LAP3	51056	broad.mit.edu	37	chr4	17583958	17583958	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggcaaaaaggcagctggAatcgacgaacaggaaaactg	16	4	12	9	3	0	0	0	0	0	0	2	4	0	2	0	4	3	3	0	4	6	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr4:17583958A>G	uc003gph.1	+	4	483	c.321A>G	c.(319-321)GGA>GGG	p.G107G	LAP3_uc010ieg.2_Intron	NM_015907	NP_056991	P28838	AMPL_HUMAN	leucine aminopeptidase 3	107					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding				0						AGGCAGCTGGAATCGACGAAC	0.438													3	24					0	0	0	0	G	17583958	G	G	17583958	2	3	64	1	0	0	0	0	0	0	0	1	8663	233	9	5		5	LAP3	4	17583958	Silent	SNP	A	TCGA-CN-5367-01A-01D-1434-08	10658746	17583958	173570318	30	12734											
EPHA5	2044	broad.mit.edu	37	chr4	66197778	66197778	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcccatcttgattgcctctAgccattcacctactgatctg	7	13	7	14	0	4	2	1	2	3	0	4	2	4	2	4	1	3	0	4	1	2	5			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr4:66197778A>T	uc003hcy.2	-	17	3114	c.2921T>A	c.(2920-2922)CTA>CAA	p.L974Q	EPHA5_uc003hcx.2_Missense_Mutation_p.L906Q|EPHA5_uc003hcz.2_Missense_Mutation_p.L952Q|EPHA5_uc011cah.1_Missense_Mutation_p.L975Q|EPHA5_uc011cai.1_Missense_Mutation_p.L953Q|EPHA5_uc003hda.2_Missense_Mutation_p.L975Q	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	974	Cytoplasmic (Potential).|SAM.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GATTGCCTCTAGCCATTCACC	0.398										TSP Lung(17;0.13)			22	49					0	0	0	0	T	66197778	T	T	66197778	3	4	64	1	0	0	0	0	1	0	0	0	5194	420	15	5	200	5	EPHA5	4	66197778	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	48613820	66197778	124956498	31	12735											
CCRN4L	25819	broad.mit.edu	37	chr4	139964425	139964425	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggttccagagggattttGtggatctgaggacagattgc	8	11	14	8	1	1	3	0	1	1	2	2	6	2	6	2	4	1	1	2	4	0	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr4:139964425G>A	uc003ihl.2	+	2	581	c.388G>A	c.(388-390)GTG>ATG	p.V130M	CCRN4L_uc003ihk.1_Missense_Mutation_p.V130M	NM_012118	NP_036250	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like	130					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_hematologic(180;0.162)					GAGGGATTTTGTGGATCTGAG	0.547													34	130					0	0	0	0	A	139964425	A	A	139964425	3	1	64	1	0	0	0	0	1	0	0	0	2966	1377	48	4	394	4	CCRN4L	4	139964425	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	73766647	139964425	51189851	32	12736											
ZNF330	27309	broad.mit.edu	37	chr4	142147942	142147942	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaaacaaagtgcatgatgaAgtcttcagactgtgtcataa	16	10	9	6	0	3	3	2	2	1	1	3	4	3	3	0	0	2	1	0	0	5	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr4:142147942A>C	uc003iiq.3	+	5	453	c.233A>C	c.(232-234)AAG>ACG	p.K78T	ZNF330_uc011chl.1_Missense_Mutation_p.K18T	NM_014487	NP_055302	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	78	C4-type 2 (Potential).					chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)					TGCATGATGAAGTCTTCAGAC	0.388													29	176					0	0	0	0	C	142147942	C	C	142147942	3	2	64	1	0	0	0	0	1	0	0	0	17915	72	3	5	247	5	ZNF330	4	142147942	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	2183517	142147942	49006334	33	12737											
H2AFY	9555	broad.mit.edu	37	chr5	134724631	134724631	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgtcaggtattccaggacGgcggccatgtacacgggtgc	7	8	14	12	3	1	0	1	0	0	0	2	1	2	1	3	5	2	2	3	5	2	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr5:134724631G>A	uc003lam.1	-	2	363	c.153C>T	c.(151-153)GCC>GCT	p.A51A	H2AFY_uc003lao.1_Silent_p.A51A|H2AFY_uc003lan.1_Silent_p.A51A|H2AFY_uc003lap.1_RNA|H2AFY_uc003laq.1_RNA|H2AFY_uc003lar.1_RNA|H2AFY_uc011cxz.1_Silent_p.A51A|H2AFY_uc003las.1_Silent_p.A51A|H2AFY_uc003lat.1_Silent_p.A51A	NM_138610	NP_613258	O75367	H2AY_HUMAN	H2A histone family, member Y isoform 3	51	Histone H2A.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATTCCAGGACGGCGGCCATGT	0.532													23	91					0	0	0	0	A	134724631	A	A	134724631	2	1	64	1	0	0	0	0	0	0	0	1	6968	1103	39	1		1	H2AFY	5	134724631	Silent	SNP	G	TCGA-CN-5367-01A-01D-1434-08		134724631	46190629	34	12738											
PCDHGA6	56109	broad.mit.edu	37	chr5	140755360	140755360	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccccgccctccccacagaCggttccactggcgtggagct	6	7	10	18	3	0	1	0	0	0	1	2	2	2	2	6	3	2	2	6	3	1	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr5:140755360C>T	uc003ljy.1	+	1	1710	c.1710C>T	c.(1708-1710)GAC>GAT	p.D570D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.D570D	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	570	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCCACAGACGGTTCCACTG	0.667													48	168					0	0	0	0	T	140755360	T	T	140755360	2	4	64	1	0	0	0	0	0	0	0	1	11612	535	19	1		1	PCDHGA6	5	140755360	Silent	SNP	C	TCGA-CN-5367-01A-01D-1434-08	6030729	140755360	40159900	35	12739											
LARP1	23367	broad.mit.edu	37	chr5	154179561	154179561	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggattctgagaactggattGaagtgaagaagaggcctcgg	12	9	15	5	1	1	5	0	3	1	3	2	8	1	7	1	4	1	0	1	4	4	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr5:154179561G>T	uc003lvp.2	+	10	2104	c.1675G>T	c.(1675-1677)GAA>TAA	p.E559*	LARP1_uc003lvo.2_Nonsense_Mutation_p.E482*|LARP1_uc010jie.1_Nonsense_Mutation_p.E354*	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	559							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GAACTGGATTGAAGTGAAGAA	0.577													20	58					7.45023e-12	8.3815e-12	1	0	T	154179561	T	T	154179561	4	4	64	1	0	0	0	0	0	1	0	0	8668	1291	45	2	1482	2	LARP1	5	154179561	Nonsense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	13424201	154179561	26735699	36	12740											
HIST1H2AG	8969	broad.mit.edu	37	chr6	27101004	27101004	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggccggcgcgccggtgtatCtggcagcggtgctggagtac	4	7	19	11	5	1	0	0	0	1	0	1	1	1	1	2	6	3	4	2	6	2	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr6:27101004C>T	uc003niw.2	+	1	188	c.154C>T	c.(154-156)CTG>TTG	p.L52L	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	52					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GCCGGTGTATCTGGCAGCGGT	0.677													14	51					0	0	0	0	T	27101004	T	T	27101004	2	4	64	1	0	0	0	0	0	0	0	1	7172	912	32	2		2	HIST1H2AG	6	27101004	Silent	SNP	C	TCGA-CN-5367-01A-01D-1434-08		27101004	144014063	37	12741											
NKAPL	222698	broad.mit.edu	37	chr6	28227211	28227211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggctctcggagaaggcgacGcagctcctcggggagcccac	7	4	16	14	4	1	1	0	0	1	1	4	4	2	2	2	5	2	3	2	5	1	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr6:28227211G>A	uc003nkt.2	+	1	114	c.62G>A	c.(61-63)CGC>CAC	p.R21H	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	21										upper_aerodigestive_tract(1)|ovary(1)	2						AGAAGGCGACGCAGCTCCTCG	0.667													5	73					0	0	0	0	A	28227211	A	A	28227211	3	1	64	1	0	0	0	0	1	0	0	0	10494	1087	38	1	64	1	NKAPL	6	28227211	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	1126207	28227211	142887856	38	12742											
ZNF323	64288	broad.mit.edu	37	chr6	28294189	28294189	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaagccttcccacacactttGcattcatatggtttttcccc	9	14	4	14	0	1	0	1	0	0	0	3	0	3	0	4	1	2	2	4	1	2	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr6:28294189G>A	uc003nla.2	-	4	1375	c.975C>T	c.(973-975)TGC>TGT	p.C325C	ZNF323_uc003nld.2_Silent_p.C325C|ZNF323_uc010jra.2_Silent_p.C325C|ZNF323_uc003nlb.2_Silent_p.C166C|ZNF323_uc010jrb.2_Silent_p.C166C|ZNF323_uc003nlc.2_Silent_p.C325C	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	325	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CACACACTTTGCATTCATATG	0.493													17	276					0	0	0	0	A	28294189	A	A	28294189	2	1	64	1	0	0	0	0	0	0	0	1	17910	1311	46	4		4	ZNF323	6	28294189	Silent	SNP	G	TCGA-CN-5367-01A-01D-1434-08	66978	28294189	142820878	39	12743											
CD2AP	23607	broad.mit.edu	37	chr6	47471022	47471022	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcccccttttttagttgactAtattgtggagtatgactatg	8	18	8	7	0	0	2	0	2	0	0	1	3	1	3	2	1	0	2	2	1	5	9			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr6:47471022A>G	uc003oyw.2	+	2	467	c.11A>G	c.(10-12)TAT>TGT	p.Y4C		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	4	Interaction with ANLN and localization to the midbody.|SH3 1; truncated.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			TTAGTTGACTATATTGTGGAG	0.318													22	65					0	0	0	0	G	47471022	G	G	47471022	3	3	64	1	0	0	0	0	1	0	0	0	3009	449	16	5	17	5	CD2AP	6	47471022	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	19176833	47471022	123644045	40	12744											
OGFRL1	79627	broad.mit.edu	37	chr6	72011631	72011631	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaacctgagaaaacagttaCtactcccacagaaaaaaagg	19	6	6	10	0	1	2	1	1	0	2	2	3	2	2	2	1	4	1	2	1	8	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr6:72011631C>T	uc003pfx.1	+	7	1398	c.1235C>T	c.(1234-1236)ACT>ATT	p.T412I		NM_024576	NP_078852	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	412						membrane	receptor activity				0						AAAACAGTTACTACTCCCACA	0.423													34	72					0	0	0	0	T	72011631	T	T	72011631	3	4	64	1	0	0	0	0	1	0	0	0	10898	565	20	4	1261	4	OGFRL1	6	72011631	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	24540609	72011631	99103436	41	12745											
EPHA7	2045	broad.mit.edu	37	chr6	93982120	93982120	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagtactctctccttcattaCtccactcacttgcgagggag	8	12	7	14	1	3	0	2	0	1	0	6	2	5	1	2	1	3	1	2	1	2	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr6:93982120C>A	uc003poe.2	-	6	1586	c.1345G>T	c.(1345-1347)GTA>TTA	p.V449L	EPHA7_uc003pof.2_Missense_Mutation_p.V449L|EPHA7_uc011eac.1_Missense_Mutation_p.V449L	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	449	Extracellular (Potential).|Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TCCTTCATTACTCCACTCACT	0.448													10	180					4.68919e-08	5.16148e-08	1	0	A	93982120	A	A	93982120	3	1	64	1	0	0	0	0	1	0	0	0	5196	565	20	4	1699	4	EPHA7	6	93982120	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	21970489	93982120	77132947	42	12746											
FIG4	9896	broad.mit.edu	37	chr6	110037703	110037703	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggccgcttggatcttggaaAtagaacaaagatgggacaga	14	8	13	6	1	1	3	0	0	1	3	1	6	1	6	1	4	1	1	1	4	4	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr6:110037703A>G	uc003ptt.2	+	3	436	c.221A>G	c.(220-222)AAT>AGT	p.N74S	FIG4_uc011eau.1_Intron	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	74					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GATCTTGGAAATAGAACAAAG	0.418													41	160					0	0	0	0	G	110037703	G	G	110037703	3	3	64	1	0	0	0	0	1	0	0	0	5920	101	4	5	231	5	FIG4	6	110037703	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	16055583	110037703	61077364	43	12747											
REV3L	5980	broad.mit.edu	37	chr6	111689218	111689218	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttctaccatgaggagccGtccaccaatctccctataat	11	11	6	13	1	2	1	0	1	2	0	4	2	3	2	5	1	2	1	5	1	4	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr6:111689218G>A	uc003puy.3	-	14	6096	c.5773C>T	c.(5773-5775)CGG>TGG	p.R1925W	REV3L_uc003pux.3_Missense_Mutation_p.R1847W|REV3L_uc003puz.3_Missense_Mutation_p.R1847W|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1925					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		ATGAGGAGCCGTCCACCAATC	0.388								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					15	59					0	0	0	0	A	111689218	A	A	111689218	3	1	64	1	0	0	0	0	1	0	0	0	13305	1144	40	1	3695	1	REV3L	6	111689218	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	1651515	111689218	59425849	44	12748											
HSF2	3298	broad.mit.edu	37	chr6	122744792	122744792	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttccaggccatgctatcAggaagacaatttagcataga	14	9	9	9	0	1	2	1	0	0	2	2	4	2	3	2	2	2	2	2	2	5	5			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr6:122744792A>T	uc003pyu.2	+	10	1324	c.1137A>T	c.(1135-1137)TCA>TCT	p.S379S	HSF2_uc003pyv.2_Silent_p.S379S	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	379	Hydrophobic repeat HR-C.				response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		CCATGCTATCAGGAAGACAAT	0.338													5	179					0	0	0	0	T	122744792	T	T	122744792	2	4	64	1	0	0	0	0	0	0	0	1	7435	175	7	5		5	HSF2	6	122744792	Silent	SNP	A	TCGA-CN-5367-01A-01D-1434-08	11055574	122744792	48370275	45	12749											
VTA1	51534	broad.mit.edu	37	chr6	142525136	142525136	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgcaggtgtagcaagtaatActatccaacctactccacag	13	10	7	11	0	0	0	0	0	0	0	2	0	2	0	3	1	5	4	3	1	7	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr6:142525136A>G	uc003qiw.2	+	7	727	c.712A>G	c.(712-714)ACT>GCT	p.T238A	VTA1_uc011edt.1_RNA|VTA1_uc011edu.1_Intron	NM_016485	NP_057569	Q9NP79	VTA1_HUMAN	Vps20-associated 1 homolog	238	Interaction with VPS4B (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|endosome membrane	protein binding				0	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;1.34e-05)|GBM - Glioblastoma multiforme(68;0.00182)		AGCAAGTAATACTATCCAACC	0.383													14	89					0	0	0	0	G	142525136	G	G	142525136	3	3	64	1	0	0	0	0	1	0	0	0	17301	391	14	5	738	5	VTA1	6	142525136	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	19780344	142525136	28589931	46	12750											
DNAH11	8701	broad.mit.edu	37	chr7	21747448	21747448	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctacccgagaatggaaagaTggcaagtagtatttcccctt	12	10	10	9	1	0	2	0	0	0	2	1	4	1	3	3	2	1	4	3	2	6	5			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr7:21747448T>C	uc003svc.2	+	41	6730	c.6699T>C	c.(6697-6699)GAT>GAC	p.D2233D		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2233	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AATGGAAAGATGGCAAGTAGT	0.388									Kartagener_syndrome				22	39					0	0	0	0	C	21747448	C	C	21747448	2	2	64	1	0	0	0	0	0	0	0	1	4621	1461	51	5		5	DNAH11	7	21747448	Silent	SNP	T	TCGA-CN-5367-01A-01D-1434-08		21747448	137391215	47	12751											
PCLO	27445	broad.mit.edu	37	chr7	82582565	82582565	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatttggaaaatcttggtgaAgacttgttggagtgtgggga	10	13	16	2	0	1	2	0	1	1	1	1	6	1	5	0	5	0	1	0	5	3	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr7:82582565A>C	uc003uhx.2	-	5	7993	c.7704T>G	c.(7702-7704)TCT>TCG	p.S2568S	PCLO_uc003uhv.2_Silent_p.S2568S|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2499					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATCTTGGTGAAGACTTGTTGG	0.403													53	135					0	0	0	0	C	82582565	C	C	82582565	2	2	64	1	0	0	0	0	0	0	0	1	11637	59	3	5		5	PCLO	7	82582565	Silent	SNP	A	TCGA-CN-5367-01A-01D-1434-08	60835117	82582565	76556098	48	12752											
CLDN15	24146	broad.mit.edu	37	chr7	100876196	100876196	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccaccatcccgcagatacCtggggaccggaggacgaccc	9	3	13	16	3	0	1	0	0	0	1	1	5	1	4	6	5	1	1	6	5	1	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr7:100876196C>A	uc003uyg.1	-	3	637	c.383_splice	c.e3-1	p.G128_splice	CLDN15_uc003uyh.1_Splice_Site_p.G128_splice	NM_014343	NP_055158	P56746	CLD15_HUMAN	claudin 15						calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					CCGCAGATACCTGGGGACCGG	0.652													3	23					2.56e-06	2.75831e-06	1	0	A	100876196	A	A	100876196	5	1	64	1	0	0	0	0	0	0	1	0	3491	695	24	4	316	4	CLDN15	7	100876196	Splice_Site	SNP	C	TCGA-CN-5367-01A-01D-1434-08	18293631	100876196	58262467	49	12753											
MYL10	93408	broad.mit.edu	37	chr7	101256788	101256788	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcaccgtgagtgatgacgtaGcacaggtttctgtagtccag	9	11	12	9	2	2	3	1	3	1	0	3	3	3	3	2	1	1	4	2	1	2	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr7:101256788G>C	uc003uyr.2	-	8	826	c.648C>G	c.(646-648)TGC>TGG	p.C216W		NM_138403	NP_612412	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	216	EF-hand 3.					mitochondrion	calcium ion binding			ovary(1)|breast(1)	2						TGATGACGTAGCACAGGTTTC	0.547													6	143					0	0	0	0	C	101256788	C	C	101256788	3	2	64	1	0	0	0	0	1	0	0	0	10097	963	34	4	36	4	MYL10	7	101256788	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	380592	101256788	57881875	50	12754											
FEZF1	389549	broad.mit.edu	37	chr7	121942225	121942225	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcgtgcagcttgcggacAtgcttcttgaggtcaaagtt	7	13	12	9	2	2	1	1	1	1	0	3	2	2	2	0	2	4	4	0	2	1	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr7:121942225A>G	uc003vkd.2	-	4	1328	c.1254T>C	c.(1252-1254)CAT>CAC	p.H418H	FEZF1_uc003vkc.2_Silent_p.H368H|uc010lko.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	418	C2H2-type 6.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						GCTTGCGGACATGCTTCTTGA	0.498													8	104					0	0	0	0	G	121942225	G	G	121942225	2	3	64	1	0	0	0	0	0	0	0	1	5857	214	8	5		5	FEZF1	7	121942225	Silent	SNP	A	TCGA-CN-5367-01A-01D-1434-08	20685437	121942225	37196438	51	12755											
EXOC4	60412	broad.mit.edu	37	chr7	133682355	133682355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttccaggatatggctgacCgctgcttgcttgtcttacat	6	14	10	11	2	1	1	0	1	1	0	2	2	2	2	2	2	3	5	2	2	2	5			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr7:133682355C>T	uc003vrk.2	+	15	2352	c.2317C>T	c.(2317-2319)CGC>TGC	p.R773C	EXOC4_uc011kpo.1_Missense_Mutation_p.R672C|EXOC4_uc003vrl.2_Missense_Mutation_p.R383C|EXOC4_uc011kpp.1_Missense_Mutation_p.R305C|EXOC4_uc011kpq.1_Missense_Mutation_p.R61C	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	773					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				TATGGCTGACCGCTGCTTGCT	0.488													10	30					0	0	0	0	T	133682355	T	T	133682355	3	4	64	1	0	0	0	0	1	0	0	0	5330	652	23	1	2384	1	EXOC4	7	133682355	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	11740130	133682355	25456308	52	12756											
TTC26	79989	broad.mit.edu	37	chr7	138827003	138827003	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcttggatttttttttcagcTtcaaaaagccgactccaaaa	12	14	6	9	1	2	0	2	0	0	0	3	2	3	1	2	1	2	2	2	1	4	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr7:138827003T>C	uc003vus.2	+	5	465	c.351T>C	c.(349-351)GCT>GCC	p.A117A	TTC26_uc003vuq.2_Silent_p.A117A|TTC26_uc011kqm.1_Silent_p.A117A|TTC26_uc003vur.3_Silent_p.A117A|TTC26_uc011kqn.1_Silent_p.A117A|TTC26_uc011kqo.1_Silent_p.A86A|TTC26_uc011kqp.1_Silent_p.A12A|TTC26_uc003vut.2_5'UTR|TTC26_uc011kqq.1_Silent_p.A117A	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	117	TPR 2.						binding			ovary(1)	1						TTTTTTCAGCTTCAAAAAGCC	0.348													40	106					0	0	0	0	C	138827003	C	C	138827003	2	2	64	1	0	0	0	0	0	0	0	1	16762	1623	56	5		5	TTC26	7	138827003	Silent	SNP	T	TCGA-CN-5367-01A-01D-1434-08	5144648	138827003	20311660	53	12757											
MGAM	8972	broad.mit.edu	37	chr7	141708357	141708357	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgggacaactggtacccCagatcctggaacaactggta	11	8	10	12	0	0	1	0	0	0	1	2	3	2	3	4	4	4	2	4	4	5	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr7:141708357C>G	uc003vwy.2	+	3	233	c.179C>G	c.(178-180)CCA>CGA	p.P60R		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	60	Ser/Thr-rich.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ACTGGTACCCCAGATCCTGGA	0.483													12	29					0	0	0	0	G	141708357	G	G	141708357	3	3	64	1	0	0	0	0	1	0	0	0	9594	594	21	4	185	4	MGAM	7	141708357	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	2881354	141708357	17430306	54	12758											
PRKDC	5591	broad.mit.edu	37	chr8	48868498	48868498	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tatcttttgtataaacactgGtacaagtgttctaggtttta	11	18	7	5	0	2	0	0	0	2	0	2	0	2	0	0	2	2	4	0	2	8	10			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr8:48868498G>A	uc003xqi.2	-	4	392	c.335C>T	c.(334-336)ACC>ATC	p.T112I	PRKDC_uc003xqj.2_Missense_Mutation_p.T112I|PRKDC_uc011ldh.1_Missense_Mutation_p.T112I	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	112					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ATAAACACTGGTACAAGTGTT	0.308								NHEJ					4	32					0	0	0	0	A	48868498	A	A	48868498	3	1	64	1	0	0	0	0	1	0	0	0	12583	1261	44	4	12382	4	PRKDC	8	48868498	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08		48868498	97495524	55	12759											
SLCO5A1	81796	broad.mit.edu	37	chr8	70667779	70667779	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagaaaattttttcttttTctttttcttgtgtcgaggtg	8	21	7	5	1	3	1	0	0	3	1	4	2	3	1	0	1	1	0	0	1	3	8			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr8:70667779T>C	uc003xyl.2	-	4	1845	c.1138A>G	c.(1138-1140)AAA>GAA	p.K380E	SLCO5A1_uc010lzb.2_Missense_Mutation_p.K380E|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Missense_Mutation_p.K380E|SLCO5A1_uc010lzc.2_Missense_Mutation_p.K380E	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	380	Cytoplasmic (Potential).|Poly-Lys.					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TTTTTCTTTTTCTTTTTCTTG	0.383													8	105					0	0	0	0	C	70667779	C	C	70667779	3	2	64	1	0	0	0	0	1	0	0	0	14795	1792	62	5	1436	5	SLCO5A1	8	70667779	Missense_Mutation	SNP	T	TCGA-CN-5367-01A-01D-1434-08	21799281	70667779	75696243	56	12760											
HNRNPK	3190	broad.mit.edu	37	chr9	86587824	86587824	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcgggttttcctccaataaGaacaactctgtcagtggaat	12	12	8	9	1	2	1	1	0	1	1	5	2	4	2	2	2	2	1	2	2	5	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr9:86587824G>C	uc004ang.3	-	10	804	c.580C>G	c.(580-582)CTT>GTT	p.L194V	HNRNPK_uc011lsw.1_5'UTR|HNRNPK_uc004and.3_5'UTR|HNRNPK_uc004ank.3_Missense_Mutation_p.L194V|HNRNPK_uc004anf.3_Missense_Mutation_p.L194V|HNRNPK_uc004anh.3_Missense_Mutation_p.L170V|HNRNPK_uc011lsx.1_Missense_Mutation_p.L170V|HNRNPK_uc004ani.3_Missense_Mutation_p.L194V|HNRNPK_uc004anj.3_Missense_Mutation_p.L194V|HNRNPK_uc004ann.3_Missense_Mutation_p.L170V|HNRNPK_uc004anl.3_Missense_Mutation_p.L194V|HNRNPK_uc004anm.3_Missense_Mutation_p.L194V	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	194	5 X 4 AA repeats of G-X-G-G.|Necessary for interaction with DDX1.|2 X 22 AA approximate repeats.|Interaction with ASFV p30.|KH 2.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						CCTCCAATAAGAACAACTCTG	0.343													10	116					0	0	0	0	C	86587824	C	C	86587824	3	2	64	1	0	0	0	0	1	0	0	0	7308	942	33	2	881	2	HNRNPK	9	86587824	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08		86587824	54625607	57	12761											
ZNF462	58499	broad.mit.edu	37	chr9	109688535	109688535	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaaacatcacccacgattAcaatgccaccaatggggctg	14	6	8	13	1	1	1	1	0	0	1	1	2	1	1	3	2	3	1	3	2	4	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr9:109688535A>G	uc004bcz.2	+	3	2631	c.2342A>G	c.(2341-2343)TAC>TGC	p.Y781C	ZNF462_uc010mto.2_Missense_Mutation_p.Y629C|ZNF462_uc004bda.2_Missense_Mutation_p.Y629C	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	781					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						ACCCACGATTACAATGCCACC	0.448													6	99					0	0	0	0	G	109688535	G	G	109688535	3	3	64	1	0	0	0	0	1	0	0	0	17993	391	14	5	2348	5	ZNF462	9	109688535	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	23100711	109688535	31524896	58	12762											
LPAR1	1902	broad.mit.edu	37	chr9	113703901	113703901	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcactgtagaggggtgccAtgttggaacaattttcaata	12	12	11	6	0	2	1	2	0	0	1	2	2	2	2	1	3	2	2	1	3	5	5			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr9:113703901A>G	uc004bfa.2	-	4	848	c.593T>C	c.(592-594)ATG>ACG	p.M198T	LPAR1_uc011lwm.1_Missense_Mutation_p.M199T|LPAR1_uc004bfb.2_Missense_Mutation_p.M198T|LPAR1_uc004bfc.2_Missense_Mutation_p.M198T|LPAR1_uc011lwn.1_Missense_Mutation_p.M180T|LPAR1_uc011lwo.1_Missense_Mutation_p.M199T|LPAR1_uc010mub.2_Missense_Mutation_p.M198T	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	198	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						GAGGGGTGCCATGTTGGAACA	0.458													90	67					0	0	0	0	G	113703901	G	G	113703901	3	3	64	1	0	0	0	0	1	0	0	0	8954	217	8	5	509	5	LPAR1	9	113703901	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	4015366	113703901	27509530	59	12763											
C9orf172	389813	broad.mit.edu	37	chr9	139739061	139739062	+	Frame_Shift_Ins	INS	-	A	A																															tggacgggccggccatggagINSaccctgccggagccaccgcc																										TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr9:139739061_139739062insA	uc011meh.1	+	1	195_196	c.195_196insA	c.(193-198)GAGACCfs	p.E65fs		NM_001080482	NP_001073951	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	65_66											0						CGGCCATGGAGACCCTGCCGGA	0.708													---	---	---								A	139739062	A	A	139739061	7	5	64	1	0	1	1	0	0	0	0	0	2483	933	33	0	197	0	C9orf172	9	139739061	Frame_Shift_Ins	INS	-	TCGA-CN-5367-01A-01D-1434-08	26035160	139739061	1474370	60	12764											
CUBN	8029	broad.mit.edu	37	chr10	17061945	17061945	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctggagggggcaggtctactCcacagtagcgtcccatctgc	7	8	13	13	1	2	0	0	0	2	0	4	1	4	1	2	4	3	2	2	4	2	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr10:17061945C>T	uc001ioo.2	-	28	4107	c.4055G>A	c.(4054-4056)GGA>GAA	p.G1352E		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1352	CUB 8.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGGTCTACTCCACAGTAGCG	0.493													14	59					0	0	0	0	T	17061945	T	T	17061945	3	4	64	1	0	0	0	0	1	0	0	0	4068	855	30	2	6976	2	CUBN	10	17061945	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08		17061945	118472802	61	12765											
WAPAL	23063	broad.mit.edu	37	chr10	88227232	88227232	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacgatctctactcagtataTacatgagggcagctgtacag	13	10	9	9	1	2	1	1	1	1	0	3	2	2	1	0	1	5	4	0	1	6	5			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr10:88227232T>C	uc001kdo.2	-	9	2616	c.2174A>G	c.(2173-2175)TAT>TGT	p.Y725C	WAPAL_uc009xsv.2_Missense_Mutation_p.Y39C|WAPAL_uc001kdn.2_Missense_Mutation_p.Y762C|WAPAL_uc009xsw.2_Missense_Mutation_p.Y719C	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	725	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						ACTCAGTATATACATGAGGGC	0.388													14	49					0	0	0	0	C	88227232	C	C	88227232	3	2	64	1	0	0	0	0	1	0	0	0	17316	1406	49	5	1442	5	WAPAL	10	88227232	Missense_Mutation	SNP	T	TCGA-CN-5367-01A-01D-1434-08	71165287	88227232	47307515	62	12766											
CEP55	55165	broad.mit.edu	37	chr10	95287808	95287808	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccaaaaagtcccactgcTgcactcaatgaaagcctggt	13	8	7	13	0	2	1	2	1	0	0	3	1	3	1	3	1	3	2	3	1	4	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr10:95287808T>C	uc009xug.2	+	9	1475	c.1293T>C	c.(1291-1293)GCT>GCC	p.A431A	CEP55_uc001kiq.3_Silent_p.A431A	NM_001127182	NP_001120654	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	431	Required for localization to the interphase centrosome and to the midbody during cytokinesis.				cell division|mitosis	centriole|cleavage furrow|midbody					0		Colorectal(252;0.207)				GTCCCACTGCTGCACTCAATG	0.463													23	64					0	0	0	0	C	95287808	C	C	95287808	2	2	64	1	0	0	0	0	0	0	0	1	3270	1567	55	5		5	CEP55	10	95287808	Silent	SNP	T	TCGA-CN-5367-01A-01D-1434-08	7060576	95287808	40246939	63	12767											
MUC5B	727897	broad.mit.edu	37	chr11	1274140	1274140	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgtggccaacgtcacctgCgtgaacaagcacctgcccat	9	7	9	16	2	1	1	1	1	0	0	1	1	1	1	5	1	5	1	5	1	3	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr11:1274140C>G	uc009ycr.1	+	54	16239	c.16113C>G	c.(16111-16113)TGC>TGG	p.C5371W	MUC5B_uc001ltb.2_Missense_Mutation_p.C5052W	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5049					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACGTCACCTGCGTGAACAAGC	0.617													6	33					0	0	0	0	G	1274140	G	G	1274140	3	3	64	1	0	0	0	0	1	0	0	0	10032	776	27	3	15286	3	MUC5B	11	1274140	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08		1274140	133732376	64	12768											
OR10A3	26496	broad.mit.edu	37	chr11	7960501	7960501	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaataagaaggtgtctgcAcacacaagctctagtaccgg	14	8	9	10	1	3	1	1	0	2	1	3	1	3	1	1	2	3	3	1	2	6	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr11:7960501A>G	uc010rbi.1	-	1	567	c.567T>C	c.(565-567)TGT>TGC	p.C189C		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGGTGTCTGCACACACAAGCT	0.418													5	95					0	0	0	0	G	7960501	G	G	7960501	2	3	64	1	0	0	0	0	0	0	0	1	10945	157	6	5		5	OR10A3	11	7960501	Silent	SNP	A	TCGA-CN-5367-01A-01D-1434-08	6686361	7960501	127046015	65	12769											
PDE3B	5140	broad.mit.edu	37	chr11	14853185	14853185	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgtttccctgtatgtacaGattgaacaggaagtatcact	11	14	9	7	0	1	2	1	1	0	1	2	3	2	3	1	1	2	5	1	1	5	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr11:14853185G>C	uc001mln.2	+	9	2310	c.1957_splice	c.e9-1	p.I653_splice	PDE3B_uc010rcr.1_Splice_Site_p.I602_splice	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B						cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						TGTATGTACAGATTGAACAGG	0.279													33	62					0	0	0	0	C	14853185	C	C	14853185	5	2	64	1	0	0	0	0	0	0	1	0	11692	956	33	2	1990	2	PDE3B	11	14853185	Splice_Site	SNP	G	TCGA-CN-5367-01A-01D-1434-08	6892684	14853185	120153331	66	12770											
DDB1	1642	broad.mit.edu	37	chr11	61097015	61097015	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccggcactcagggtcaatGatgccaataatgccggtctc	10	9	10	12	2	3	1	2	1	1	0	5	1	4	1	3	3	2	1	3	3	3	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr11:61097015G>T	uc001nrc.3	-	4	595	c.369C>A	c.(367-369)ATC>ATA	p.I123I	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Silent_p.I123I|DDB1_uc010rlg.1_5'Flank|DDB1_uc001nrd.2_Silent_p.I123I|DDB1_uc009ynl.1_Intron	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	123	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						CAGGGTCAATGATGCCAATAA	0.498								NER					9	14					0.000274275	0.000287425	1	0	T	61097015	T	T	61097015	2	4	64	1	0	0	0	0	0	0	0	1	4340	1280	45	2		2	DDB1	11	61097015	Silent	SNP	G	TCGA-CN-5367-01A-01D-1434-08	46243830	61097015	73909501	67	12771											
SCYL1	57410	broad.mit.edu	37	chr11	65303563	65303563	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcccagaagatcctgcCtgtgctctgcggtctcactg	5	11	11	14	1	2	2	1	0	2	2	4	2	3	2	3	1	4	1	3	1	1	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr11:65303563C>T	uc001oea.1	+	11	1603	c.1526C>T	c.(1525-1527)CCT>CTT	p.P509L	SCYL1_uc009yqk.2_Missense_Mutation_p.P509L|SCYL1_uc001oeb.1_Missense_Mutation_p.P509L|SCYL1_uc001oec.1_Missense_Mutation_p.P509L|SCYL1_uc001oed.1_Missense_Mutation_p.P366L|SCYL1_uc001oee.1_Missense_Mutation_p.P153L	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	509	HEAT 3.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						AAGATCCTGCCTGTGCTCTGC	0.617													39	71					0	0	0	0	T	65303563	T	T	65303563	3	4	64	1	0	0	0	0	1	0	0	0	14012	681	24	4	1568	4	SCYL1	11	65303563	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	4206548	65303563	69702953	68	12772											
TCIRG1	10312	broad.mit.edu	37	chr11	67811734	67811734	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcagcgtgagcaccacgCacaagtgcctcattgccgag	10	6	12	13	3	1	1	1	1	0	0	1	2	1	1	3	0	5	3	3	0	1	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr11:67811734C>T	uc001one.2	+	9	1051	c.943C>T	c.(943-945)CAC>TAC	p.H315Y	TCIRG1_uc001ong.2_Missense_Mutation_p.H99Y|TCIRG1_uc001onh.2_Missense_Mutation_p.H17Y|TCIRG1_uc001oni.2_5'UTR	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	315	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						GAGCACCACGCACAAGTGCCT	0.687													4	31					0	0	0	0	T	67811734	T	T	67811734	3	4	64	1	0	0	0	0	1	0	0	0	15769	710	25	4	973	4	TCIRG1	11	67811734	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	2508171	67811734	67194782	69	12773											
GUCY1A2	2977	broad.mit.edu	37	chr11	106681089	106681089	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcatggatagggatgtctGagagatgtagccctcggccc	9	9	13	10	1	2	2	1	1	1	1	3	5	2	4	2	3	1	1	2	3	2	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr11:106681089G>C	uc001pjg.1	-	5	1712	c.1322C>G	c.(1321-1323)TCA>TGA	p.S441*	GUCY1A2_uc010rvo.1_Nonsense_Mutation_p.S462*|GUCY1A2_uc009yxn.1_Nonsense_Mutation_p.S441*	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	441					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		AGGGATGTCTGAGAGATGTAG	0.453													102	811					0	0	0	0	C	106681089	C	C	106681089	4	2	64	1	0	0	0	0	0	1	0	0	6932	1294	45	2	892	2	GUCY1A2	11	106681089	Nonsense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	38869355	106681089	28325427	70	12774											
GUCY1A2	2977	broad.mit.edu	37	chr11	106681158	106681158	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagagcccaaaaataaaatgGaatttgattctggaacatgg	17	9	10	5	0	1	2	0	1	1	1	1	5	1	4	1	3	2	0	1	3	6	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr11:106681158G>T	uc001pjg.1	-	5	1643	c.1253C>A	c.(1252-1254)TCC>TAC	p.S418Y	GUCY1A2_uc010rvo.1_Missense_Mutation_p.S439Y|GUCY1A2_uc009yxn.1_Missense_Mutation_p.S418Y	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	418					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		AAATAAAATGGAATTTGATTC	0.423													89	858					7.49063e-41	8.68232e-41	1	0	T	106681158	T	T	106681158	3	4	64	1	0	0	0	0	1	0	0	0	6932	1174	41	2	961	2	GUCY1A2	11	106681158	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	69	106681158	28325358	71	12775											
FXYD2	486	broad.mit.edu	37	chr11	117695379	117695379	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacactcaccaccgtccatCgacaacccagtcatttcccc	10	7	4	20	2	2	0	2	0	0	0	5	1	4	0	6	0	1	1	6	0	1	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr11:117695379C>T	uc001prj.2	-	1	81	c.15G>A	c.(13-15)TCG>TCA	p.S5S	FXYD2_uc001prl.2_Silent_p.S5S|FXYD2_uc001prk.1_Intron	NM_001680	NP_001671	P54710	ATNG_HUMAN	FXYD domain-containing ion transport regulator 2	5						sodium:potassium-exchanging ATPase complex	ion channel activity|sodium:potassium-exchanging ATPase activity				0	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|Breast(348;0.111)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;2.83e-05)|Epithelial(105;0.00114)	Cyclothiazide(DB00606)	CACCGTCCATCGACAACCCAG	0.612													10	24					0	0	0	0	T	117695379	T	T	117695379	2	4	64	1	0	0	0	0	0	0	0	1	6152	871	31	1		1	FXYD2	11	117695379	Silent	SNP	C	TCGA-CN-5367-01A-01D-1434-08	11014221	117695379	17311137	72	12776											
VWF	7450	broad.mit.edu	37	chr12	6094236	6094236	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcatactcggggcagcactgGtctgcattctggcggaggcg	6	9	15	11	3	3	0	1	0	2	0	4	1	3	1	0	6	3	3	0	6	1	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr12:6094236G>C	uc001qnn.1	-	40	7201	c.6951C>G	c.(6949-6951)GAC>GAG	p.D2317E	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2317	VWFC 1.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GGCAGCACTGGTCTGCATTCT	0.597													24	101					0	0	0	0	C	6094236	C	C	6094236	3	2	64	1	0	0	0	0	1	0	0	0	17314	1252	44	4	1542	4	VWF	12	6094236	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08		6094236	127757659	73	12777											
MANSC1	54682	broad.mit.edu	37	chr12	12496065	12496065	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagcaagaattaatgcagtCttcttgagttgaagtatata	15	13	8	5	0	2	3	0	2	2	1	2	3	2	3	0	0	2	4	0	0	7	7			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr12:12496065C>G	uc001rai.1	-	2	442	c.184G>C	c.(184-186)GAC>CAC	p.D62H	MANSC1_uc001raj.1_Missense_Mutation_p.D28H|MANSC1_uc009zht.1_Intron	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	62	MANSC.|Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		TTAATGCAGTCTTCTTGAGTT	0.403													4	171					0	0	0	0	G	12496065	G	G	12496065	3	3	64	1	0	0	0	0	1	0	0	0	9277	913	32	2	1123	2	MANSC1	12	12496065	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	6401829	12496065	121355830	74	12778											
PTPRO	5800	broad.mit.edu	37	chr12	15668508	15668508	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtaatatacctaaggaaagGccctttgattggaccacctt	12	12	8	9	0	0	1	0	1	0	0	0	3	0	3	4	3	1	1	4	3	5	7			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr12:15668508G>A	uc001rcv.1	+	8	1715	c.1541G>A	c.(1540-1542)GGC>GAC	p.G514D	PTPRO_uc001rcw.1_Missense_Mutation_p.G514D|PTPRO_uc001rcu.1_Missense_Mutation_p.G514D	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	514	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				CTAAGGAAAGGCCCTTTGATT	0.413													31	104					0	0	0	0	A	15668508	A	A	15668508	3	1	64	1	0	0	0	0	1	0	0	0	12874	1203	42	4	1571	4	PTPRO	12	15668508	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	3172443	15668508	118183387	75	12779											
SMUG1	23583	broad.mit.edu	37	chr12	54576179	54576179	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtaaggttgcgcccgctggGagccaggaaaagcagagggc	11	4	17	9	2	0	1	0	0	0	1	0	3	0	3	2	4	3	4	2	4	3	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr12:54576179G>A	uc001sff.1	-	4	643	c.514C>T	c.(514-516)CCC>TCC	p.P172S	SMUG1_uc001sfa.1_5'Flank|SMUG1_uc001sfe.1_3'UTR|SMUG1_uc001sfg.1_Missense_Mutation_p.P172S|SMUG1_uc009znf.1_Missense_Mutation_p.P172S|SMUG1_uc001sfb.3_Intron|SMUG1_uc001sfc.3_Intron|SMUG1_uc001sfd.3_Intron	NM_014311	NP_055126	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional	172				Missing (in Ref. 3; BAC03670).	depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity				0						CGCCCGCTGGGAGCCAGGAAA	0.577								BER_DNA_glycosylases					6	122					0	0	0	0	A	54576179	A	A	54576179	3	1	64	1	0	0	0	0	1	0	0	0	14882	1174	41	2	302	2	SMUG1	12	54576179	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	38907671	54576179	79275716	76	12780											
KERA	11081	broad.mit.edu	37	chr12	91449227	91449227	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagatgagcactgattcgggGaacctttgtgagttgattgt	9	13	13	6	1	0	5	0	4	0	1	1	6	0	6	1	2	2	2	1	2	1	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr12:91449227G>T	uc001tbl.2	-	2	1451	c.832C>A	c.(832-834)CCC>ACC	p.P278T		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	278	LRR 9.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						CTGATTCGGGGAACCTTTGTG	0.408													33	104					1.04352e-10	1.16539e-10	1	0	T	91449227	T	T	91449227	3	4	64	1	0	0	0	0	1	0	0	0	8182	1174	41	2	234	2	KERA	12	91449227	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	36873048	91449227	42402668	77	12781											
DCN	1634	broad.mit.edu	37	chr12	91558464	91558464	+	Frame_Shift_Del	DEL	G	-	-																															ggtctagcagagttgtgtcaGggggaagatcctttggcact																										TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr12:91558464delG	uc001tbs.2	-	2	336	c.242delC	c.(241-243)CCTfs	p.P81fs	DCN_uc001tbo.2_Intron|DCN_uc001tbp.2_Intron|DCN_uc001tbq.2_Frame_Shift_Del_p.P81fs|DCN_uc001tbr.2_Intron|DCN_uc001tbt.2_Frame_Shift_Del_p.P81fs|DCN_uc001tbu.2_Frame_Shift_Del_p.P81fs	NM_133503	NP_598010	P07585	PGS2_HUMAN	decorin isoform a preproprotein	81	LRR 1.				organ morphogenesis	extracellular space				central_nervous_system(2)|ovary(1)|lung(1)	4						AGTTGTGTCAGGGGGAAGATC	0.403													---	---	---								-	91558464	-	-	91558464	7	5	64	1	0	1	0	1	0	0	0	0	4314	1000	35	0	861	0	DCN	12	91558464	Frame_Shift_Del	DEL	G	TCGA-CN-5367-01A-01D-1434-08	109237	91558464	42293431	78	12782											
ZMYM2	7750	broad.mit.edu	37	chr13	20641120	20641120	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actgggtcaaaactaggcaaCttgatgaagatcttctggta	13	11	10	7	0	3	3	1	2	2	1	3	3	3	3	0	3	2	2	0	3	6	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr13:20641120C>G	uc001umr.2	+	21	3560	c.3262C>G	c.(3262-3264)CTT>GTT	p.L1088V	ZMYM2_uc001ums.2_Missense_Mutation_p.L1088V|ZMYM2_uc001umt.2_Missense_Mutation_p.L1088V|ZMYM2_uc001umv.2_Missense_Mutation_p.L468V|ZMYM2_uc001umw.2_Missense_Mutation_p.L541V	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	1088					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		AACTAGGCAACTTGATGAAGA	0.338													5	66					0	0	0	0	G	20641120	G	G	20641120	3	3	64	1	0	0	0	0	1	0	0	0	17767	565	20	4	3332	4	ZMYM2	13	20641120	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08		20641120	94528758	79	12783											
PCDH9	5101	broad.mit.edu	37	chr13	67800747	67800747	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattgtcatttagaatggaaAgagtcacagctttattctct	12	15	7	7	0	3	2	2	0	1	2	4	3	3	3	0	1	1	1	0	1	4	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr13:67800747A>G	uc001vik.2	-	2	2518	c.1826T>C	c.(1825-1827)CTT>CCT	p.L609P	PCDH9_uc001vil.2_Missense_Mutation_p.L609P|PCDH9_uc010thl.1_Missense_Mutation_p.L609P|PCDH9_uc001vin.3_Missense_Mutation_p.L609P	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	609	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TAGAATGGAAAGAGTCACAGC	0.383													13	147					0	0	0	0	G	67800747	G	G	67800747	3	3	64	1	0	0	0	0	1	0	0	0	11572	72	3	5	1903	5	PCDH9	13	67800747	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	47159627	67800747	47369131	80	12784											
ATP11A	23250	broad.mit.edu	37	chr13	113460594	113460594	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctttgtcattactgtgaCggctatcaaacaggtaagca	11	13	8	9	1	3	1	2	1	1	0	3	1	3	1	0	2	3	3	0	2	4	5			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr13:113460594C>T	uc001vsi.3	+	4	408	c.320C>T	c.(319-321)ACG>ATG	p.T107M	ATP11A_uc001vsj.3_Missense_Mutation_p.T107M|ATP11A_uc001vsm.1_Translation_Start_Site	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	107	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				ATTACTGTGACGGCTATCAAA	0.398													32	138					0	0	0	0	T	113460594	T	T	113460594	3	4	64	1	0	0	0	0	1	0	0	0	1121	536	19	1	334	1	ATP11A	13	113460594	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	45659847	113460594	1709284	81	12785											
FBXO33	254170	broad.mit.edu	37	chr14	39871062	39871078	+	Splice_Site	DEL	AATTCTATAAGGAAAAC	-	-																															atttcttcaaacagttgctgAattctataaggaaaacacat																										TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr14:39871062_39871078delAATTCTATAAGGAAAAC	uc001wvk.2	-	3	1049	c.711_splice	c.e3-1	p.Q237_splice		NM_203301	NP_976046	Q7Z6M2	FBX33_HUMAN	F-box protein 33												0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		ACAGTTGCTGAATTCTATAAGGAAAACACATGCCACA	0.364													---	---	---								-	39871078	-	-	39871062	8	5	64	1	0	1	0	1	0	0	1	0	5775	242	9	0	961	0	FBXO33	14	39871062	Splice_Site	DEL	AATTCTATAAGGAAAAC	TCGA-CN-5367-01A-01D-1434-08		39871062	67478478	82	12786											
FAM71D	161142	broad.mit.edu	37	chr14	67671509	67671509	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcacaggctccatggatgtGacggatgtcaccacgttcac	10	9	10	12	2	3	1	3	1	0	0	4	3	4	3	2	3	0	2	2	3	0	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr14:67671509G>A	uc001xja.1	+	5	869	c.615G>A	c.(613-615)GTG>GTA	p.V205V	FAM71D_uc010aqn.1_RNA	NM_173526	NP_775797	Q8N9W8	FA71D_HUMAN	hypothetical protein LOC161142	205										ovary(1)	1		all_hematologic(31;0.0116)		all cancers(60;0.00107)|BRCA - Breast invasive adenocarcinoma(234;0.00993)|OV - Ovarian serous cystadenocarcinoma(108;0.012)		CCATGGATGTGACGGATGTCA	0.493													34	145					0	0	0	0	A	67671509	A	A	67671509	2	1	64	1	0	0	0	0	0	0	0	1	5642	1277	45	2		2	FAM71D	14	67671509	Silent	SNP	G	TCGA-CN-5367-01A-01D-1434-08	27800447	67671509	39678031	83	12787											
PCNX	22990	broad.mit.edu	37	chr14	71444274	71444274	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaaagtgagcagaccagctCaactcacatagagagcatcc	16	6	8	11	0	2	3	2	1	0	2	3	4	3	3	2	0	4	3	2	0	4	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr14:71444274C>G	uc001xmo.2	+	6	1666	c.1220C>G	c.(1219-1221)TCA>TGA	p.S407*	PCNX_uc001xmn.3_Nonsense_Mutation_p.S407*|PCNX_uc010are.1_Nonsense_Mutation_p.S407*	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	407						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CAGACCAGCTCAACTCACATA	0.512													4	135					0	0	0	0	G	71444274	G	G	71444274	4	3	64	1	0	0	0	0	0	1	0	0	11645	838	29	2	1242	2	PCNX	14	71444274	Nonsense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	3772765	71444274	35905266	84	12788											
CLMN	79789	broad.mit.edu	37	chr14	95670064	95670064	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctacagtcatcaggttaaccTtgatctggaaggaatcggcc	11	10	10	10	1	3	1	2	1	1	0	4	3	3	3	2	4	2	1	2	4	4	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr14:95670064T>A	uc001yef.2	-	9	1738	c.1622A>T	c.(1621-1623)AAG>ATG	p.K541M		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	541						integral to membrane	actin binding				0				Epithelial(152;0.193)		CAGGTTAACCTTGATCTGGAA	0.433													12	156					0	0	0	0	A	95670064	A	A	95670064	3	1	64	1	0	0	0	0	1	0	0	0	3557	1609	56	5	1406	5	CLMN	14	95670064	Missense_Mutation	SNP	T	TCGA-CN-5367-01A-01D-1434-08	24225790	95670064	11679476	85	12789											
HSP90AA1	3320	broad.mit.edu	37	chr14	102548742	102548742	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccatatgtgcttgtgacaaTacagcatggagatgtcacca	12	10	10	9	0	1	2	1	1	0	1	1	3	1	2	2	1	3	2	2	1	3	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr14:102548742T>C	uc001yku.3	-	10	1985	c.1795A>G	c.(1795-1797)ATT>GTT	p.I599V	HSP90AA1_uc001ykv.3_Missense_Mutation_p.I721V	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	599					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CTTGTGACAATACAGCATGGA	0.408													14	89					0	0	0	0	C	102548742	C	C	102548742	3	2	64	1	0	0	0	0	1	0	0	0	7440	1406	49	5	411	5	HSP90AA1	14	102548742	Missense_Mutation	SNP	T	TCGA-CN-5367-01A-01D-1434-08	6878678	102548742	4800798	86	12790											
GPR176	11245	broad.mit.edu	37	chr15	40093986	40093986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagtgagcagcaagaagaCggaagtgtcagggacattga	15	5	15	6	1	1	4	1	2	0	2	1	6	1	6	0	2	3	3	0	2	3	1	rs139843045	byFrequency	TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr15:40093986C>T	uc001zkj.1	-	3	1761	c.895G>A	c.(895-897)GTC>ATC	p.V299I	GPR176_uc010uck.1_Missense_Mutation_p.V239I	NM_007223	NP_009154	Q14439	GP176_HUMAN	G protein-coupled receptor 176	299	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		AGCAAGAAGACGGAAGTGTCA	0.532											OREG0023053	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	56					0	0	0	0	T	40093986	T	T	40093986	3	4	64	1	0	0	0	0	1	0	0	0	6711	536	19	1	656	1	GPR176	15	40093986	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08		40093986	62437406	87	12791											
C15orf33	196951	broad.mit.edu	37	chr15	49663515	49663515	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacctttgttgctagtcttGataatcttgattcttccttg	8	19	6	8	0	3	2	0	2	3	0	4	2	4	2	2	0	2	2	2	0	3	9			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr15:49663515G>C	uc001zxl.2	-	12	1388	c.1094C>G	c.(1093-1095)TCA>TGA	p.S365*		NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	365										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		TGCTAGTCTTGATAATCTTGA	0.299													6	210					0	0	0	0	C	49663515	C	C	49663515	4	2	64	1	0	0	0	0	0	1	0	0	1797	1294	45	2	452	2	C15orf33	15	49663515	Nonsense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	9569529	49663515	52867877	88	12792											
HERC1	8925	broad.mit.edu	37	chr15	64067317	64067317	+	Nonsense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttgtcttagaagcgcaaatAataaacttagaccagttcga	15	12	7	7	2	1	2	0	0	1	2	2	3	1	2	1	0	2	2	1	0	7	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr15:64067317A>C	uc002amp.2	-	2	654	c.506T>G	c.(505-507)TTA>TGA	p.L169*	HERC1_uc010uil.1_Nonsense_Mutation_p.L169*|HERC1_uc010bgt.1_Nonsense_Mutation_p.L169*|HERC1_uc002amq.1_Nonsense_Mutation_p.L169*	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	169					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						AAGCGCAAATAATAAACTTAG	0.448													8	378					0	0	0	0	C	64067317	C	C	64067317	4	2	64	1	0	0	0	0	0	1	0	0	7096	372	13	5	14387	5	HERC1	15	64067317	Nonsense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	14403802	64067317	38464075	89	12793											
PTPLAD1	51495	broad.mit.edu	37	chr15	65864618	65864618	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatattcaatgagaccggacGattcagtttcacattgccat	13	12	7	9	2	3	1	3	1	0	1	3	4	3	2	2	1	1	1	2	1	3	5			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr15:65864618G>A	uc002apc.2	+	10	1074	c.926G>A	c.(925-927)CGA>CAA	p.R309Q	PTPLAD1_uc002apb.1_RNA|PTPLAD1_uc010uiw.1_Missense_Mutation_p.R254Q	NM_016395	NP_057479	Q9P035	HACD3_HUMAN	protein tyrosine phosphatase-like A domain	309	Lumenal (Potential).				activation of JUN kinase activity|fatty acid biosynthetic process|I-kappaB kinase/NF-kappaB cascade|Rac protein signal transduction	endoplasmic reticulum membrane|integral to membrane	GTPase activator activity|lyase activity|protein binding				0						GAGACCGGACGATTCAGTTTC	0.318													13	137					0	0	0	0	A	65864618	A	A	65864618	3	1	64	1	0	0	0	0	1	0	0	0	12838	1058	37	1	964	1	PTPLAD1	15	65864618	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	1797301	65864618	36666774	90	12794											
A2BP1	54715	broad.mit.edu	37	chr16	7568364	7568364	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagagcccggcggacacgagCgctcagaccgtctctggcac	8	4	13	16	5	2	2	1	0	1	2	3	4	2	3	2	3	2	2	2	3	0	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr16:7568364C>T	uc002cys.2	+	5	1231	c.243C>T	c.(241-243)AGC>AGT	p.S81S	A2BP1_uc010buf.1_Silent_p.S81S|A2BP1_uc002cyr.1_Silent_p.S81S|A2BP1_uc002cyt.2_Silent_p.S81S|A2BP1_uc010uxz.1_Silent_p.S124S|A2BP1_uc010uya.1_Silent_p.S117S|A2BP1_uc002cyv.1_Silent_p.S81S|A2BP1_uc010uyb.1_Silent_p.S81S|A2BP1_uc002cyw.2_Silent_p.S101S|A2BP1_uc002cyy.2_Silent_p.S101S|A2BP1_uc002cyx.2_Silent_p.S101S|A2BP1_uc010uyc.1_Silent_p.S101S	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	81					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		CGGACACGAGCGCTCAGACCG	0.657													24	100					0	0	0	0	T	7568364	T	T	7568364	2	4	64	1	0	0	0	0	0	0	0	1	3	767	27	1		1	A2BP1	16	7568364	Silent	SNP	C	TCGA-CN-5367-01A-01D-1434-08		7568364	82786389	91	12795											
CDH11	1009	broad.mit.edu	37	chr16	65016076	65016076	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatagggggctcatcagcAtcttctactgagatcttgac	11	11	9	10	0	5	2	2	2	3	1	5	3	5	2	0	2	3	2	0	2	3	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr16:65016076A>G	uc002eoi.2	-	8	1562	c.1128T>C	c.(1126-1128)GAT>GAC	p.D376D	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Silent_p.D376D|CDH11_uc010vin.1_Silent_p.D250D|CDH11_uc002eok.1_RNA	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	376	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GCTCATCAGCATCTTCTACTG	0.517			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			12	129					0	0	0	0	G	65016076	G	G	65016076	2	3	64	1	0	0	0	0	0	0	0	1	3112	214	8	5		5	CDH11	16	65016076	Silent	SNP	A	TCGA-CN-5367-01A-01D-1434-08	57447712	65016076	25338677	92	12796											
FHOD1	29109	broad.mit.edu	37	chr16	67265094	67265094	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctggcaggtgctaaccttGgcacagcgggtcagggcagg	7	8	16	10	1	2	0	1	0	1	0	2	0	2	0	1	6	3	4	1	6	1	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr16:67265094G>A	uc002esl.2	-	17	2776	c.2664C>T	c.(2662-2664)GCC>GCT	p.A888A	FHOD1_uc002esk.2_5'Flank|FHOD1_uc010ced.2_Silent_p.A695A	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	888	Potential.|FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TGCTAACCTTGGCACAGCGGG	0.602													6	43					0	0	0	0	A	67265094	A	A	67265094	2	1	64	1	0	0	0	0	0	0	0	1	5914	1335	47	4		4	FHOD1	16	67265094	Silent	SNP	G	TCGA-CN-5367-01A-01D-1434-08	2249018	67265094	23089659	93	12797											
FTSJD1	55783	broad.mit.edu	37	chr16	71319616	71319616	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taggttttttacttcatttaGggagttcttcaaatcaagaa	12	17	7	5	0	4	1	3	0	1	1	4	2	4	2	0	2	1	2	0	2	6	9			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr16:71319616G>C	uc010cga.2	-	3	614	c.208C>G	c.(208-210)CTA>GTA	p.L70V	FTSJD1_uc002ezy.3_Missense_Mutation_p.L70V|FTSJD1_uc002ezz.3_Missense_Mutation_p.L70V	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	70						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						ACTTCATTTAGGGAGTTCTTC	0.398													29	129					0	0	0	0	C	71319616	C	C	71319616	3	2	64	1	0	0	0	0	1	0	0	0	6124	991	35	4	2108	4	FTSJD1	16	71319616	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	4054522	71319616	19035137	94	12798											
DYNLRB2	83657	broad.mit.edu	37	chr16	80583408	80583408	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catccgaacaaccttggacaActcaacaactgttcaatatg	15	9	5	12	1	2	0	2	0	0	0	3	2	3	1	2	1	5	1	2	1	7	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr16:80583408A>G	uc002ffo.2	+	5	227	c.107A>G	c.(106-108)AAC>AGC	p.N36S	DYNLRB2_uc002ffp.2_RNA|DYNLRB2_uc002ffq.2_RNA	NM_130897	NP_570967	Q8TF09	DLRB2_HUMAN	dynein, light chain, roadblock-type 2	36					microtubule-based movement|transport	cytoplasmic dynein complex|microtubule	microtubule motor activity				0						ACCTTGGACAACTCAACAACT	0.358													12	36					0	0	0	0	G	80583408	G	G	80583408	3	3	64	1	0	0	0	0	1	0	0	0	4873	43	2	5	117	5	DYNLRB2	16	80583408	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	9263792	80583408	9771345	95	12799											
BANP	54971	broad.mit.edu	37	chr16	88069000	88069000	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagatcacgcaggacagcgaGgtgagtcagctctcgctgca	10	6	13	12	3	3	2	2	1	1	1	4	4	3	3	0	2	3	4	0	2	0	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr16:88069000G>T	uc002fkr.2	+	10	1460	c.1236G>T	c.(1234-1236)GAG>GAT	p.E412D	BANP_uc002fkp.2_Missense_Mutation_p.E385D|BANP_uc002fkq.2_Missense_Mutation_p.E385D|BANP_uc010vow.1_Missense_Mutation_p.E420D|BANP_uc002fks.3_Missense_Mutation_p.E381D	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	413	Gln-rich.				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		AGGACAGCGAGGTGAGTCAGC	0.632													8	16					0.000274275	0.000287425	1	0	T	88069000	T	T	88069000	3	4	64	1	0	0	0	0	1	0	0	0	1312	1014	35	4	1324	4	BANP	16	88069000	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	7485592	88069000	2285753	96	12800											
TP53	7157	broad.mit.edu	37	chr17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccaggacaggcacaaacacGcacctcaaagctgttccgtc	12	5	8	16	2	1	0	1	0	0	0	3	1	2	1	3	2	2	4	3	2	2	1	rs121913343		TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	39					0	0	0	0	A	7577121	A	A	7577121	3	1	64	1	0	0	0	0	1	0	0	0	16448	1087	38	1	469	1	TP53	17	7577121	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08		7577121	73618089	97	12801											
TP53	7157	broad.mit.edu	37	chr17	7578449	7578449	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtgactgcttgtagatggCcatggcgcggacgcgggtgc	5	9	17	10	4	0	2	0	1	0	1	0	3	0	3	1	4	2	2	1	4	1	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr17:7578449C>T	uc002gim.2	-	5	675	c.481G>A	c.(481-483)GCC>ACC	p.A161T	TP53_uc002gig.1_Missense_Mutation_p.A161T|TP53_uc002gih.2_Missense_Mutation_p.A161T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A29T|TP53_uc010cng.1_Missense_Mutation_p.A29T|TP53_uc002gii.1_Missense_Mutation_p.A29T|TP53_uc010cnh.1_Missense_Mutation_p.A161T|TP53_uc010cni.1_Missense_Mutation_p.A161T|TP53_uc002gij.2_Missense_Mutation_p.A161T|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A68T|TP53_uc002gio.2_Missense_Mutation_p.A29T|TP53_uc010vug.1_Missense_Mutation_p.A122T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	161	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		MA -> IP (in a sporadic cancer; somatic mutation).|MA -> IS (in sporadic cancers; somatic mutation).|MA -> IT (in a sporadic cancer; somatic mutation).|A -> G (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A161T(44)|p.A161D(8)|p.0?(7)|p.A161V(7)|p.A161A(5)|p.A161fs*9(3)|p.R156_I162delRVRAMAI(2)|p.M160fs*10(2)|p.V157_C176del20(1)|p.A161fs*19(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.A161fs*10(1)|p.R156_A161del(1)|p.V157fs*9(1)|p.A161fs*20(1)|p.M160_A161>IS(1)|p.A161fs*8(1)|p.A161G(1)|p.S149fs*72(1)|p.A161fs*7(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.A161S(1)|p.A161P(1)|p.V157_I162delVRAMAI(1)|p.A161F(1)|p.A159_Q167delAMAIYKQSQ(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGTAGATGGCCATGGCGCGG	0.632		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	62					0	0	0	0	T	7578449	T	T	7578449	3	4	64	1	0	0	0	0	1	0	0	0	16448	739	26	4	817	4	TP53	17	7578449	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	1328	7578449	73616761	98	12802											
PIK3R5	23533	broad.mit.edu	37	chr17	8808132	8808132	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcaatgaaggtgagcagcTcctggcagatgctgcagtaa	12	8	12	9	0	1	3	1	2	0	1	2	3	2	3	1	2	4	6	1	2	3	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr17:8808132T>C	uc002glt.2	-	5	441	c.374A>G	c.(373-375)GAG>GGG	p.E125G	PIK3R5_uc010vuz.1_Missense_Mutation_p.E125G|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Missense_Mutation_p.E125G|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	125					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GGTGAGCAGCTCCTGGCAGAT	0.582													28	57					0	0	0	0	C	8808132	C	C	8808132	3	2	64	1	0	0	0	0	1	0	0	0	11977	1551	54	5	2328	5	PIK3R5	17	8808132	Missense_Mutation	SNP	T	TCGA-CN-5367-01A-01D-1434-08	1229683	8808132	72387078	99	12803											
PIGW	284098	broad.mit.edu	37	chr17	34893088	34893088	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcattttctcacagtacttGtgttctttttcacctacctg	7	19	4	11	0	4	0	3	0	2	0	5	0	4	0	2	0	2	2	2	0	2	8			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr17:34893088G>A	uc002hmy.1	+	2	181	c.138G>A	c.(136-138)TTG>TTA	p.L46L	MYO19_uc002hmw.2_5'Flank|MYO19_uc010cuu.2_5'Flank|MYO19_uc010wcy.1_5'Flank|MYO19_uc010wcz.1_5'Flank|MYO19_uc010wda.1_5'Flank|MYO19_uc002hmx.2_5'Flank|PIGW_uc002hmz.1_Silent_p.L46L	NM_178517	NP_848612	Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan, class W	46					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CACAGTACTTGTGTTCTTTTT	0.448													8	246					0	0	0	0	A	34893088	A	A	34893088	2	1	64	1	0	0	0	0	0	0	0	1	11957	1368	48	4		4	PIGW	17	34893088	Silent	SNP	G	TCGA-CN-5367-01A-01D-1434-08	26084956	34893088	46302122	100	12804											
ST6GALNAC2	10610	broad.mit.edu	37	chr17	74563605	74563605	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatatataggtctccaaaaTgtgtgttaatcaactttgat	13	15	7	6	0	2	1	1	1	1	0	3	1	2	1	1	1	1	2	1	1	7	5			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr17:74563605T>C	uc002jsg.3	-	8	1142	c.887A>G	c.(886-888)CAT>CGT	p.H296R		NM_006456	NP_006447	Q9UJ37	SIA7B_HUMAN	sialyltransferase 7B	296	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity				0						GTCTCCAAAATGTGTGTTAAT	0.443													12	51					0	0	0	0	C	74563605	C	C	74563605	3	2	64	1	0	0	0	0	1	0	0	0	15290	1464	51	5	245	5	ST6GALNAC2	17	74563605	Missense_Mutation	SNP	T	TCGA-CN-5367-01A-01D-1434-08	39670517	74563605	6631605	101	12805											
MYOM1	8736	broad.mit.edu	37	chr18	3067467	3067467	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcgaacttgaggttgcagtgGtcgtctgaggccagggcctt	6	11	15	9	2	1	2	0	2	1	0	3	3	1	2	2	4	2	2	2	4	1	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr18:3067467G>C	uc002klp.2	-	38	5185	c.4851C>G	c.(4849-4851)GAC>GAG	p.D1617E	MYOM1_uc002klq.2_Missense_Mutation_p.D1521E	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1617	Ig-like C2-type 5.			D -> G (in Ref. 2; BAC86128).		striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GGTTGCAGTGGTCGTCTGAGG	0.587													472	22					0	0	0	0	C	3067467	C	C	3067467	3	2	64	1	0	0	0	0	1	0	0	0	10144	1252	44	4	210	4	MYOM1	18	3067467	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08		3067467	75009781	102	12806											
SPIRE1	56907	broad.mit.edu	37	chr18	12493083	12493083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactcacctaatctgctacGtctaatctcctctggtgata	9	13	7	12	1	5	1	1	1	4	0	6	2	5	2	2	2	2	1	2	2	4	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr18:12493083G>A	uc002kre.2	-	8	1224	c.1177C>T	c.(1177-1179)CGT>TGT	p.R393C	SPIRE1_uc002krc.2_RNA|SPIRE1_uc010wzw.1_Missense_Mutation_p.R273C|SPIRE1_uc010wzx.1_Missense_Mutation_p.R196C|SPIRE1_uc010wzy.1_Missense_Mutation_p.R393C	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a	393						cytoskeleton|perinuclear region of cytoplasm	actin binding				0						AATCTGCTACGTCTAATCTCC	0.468													18	37					0	0	0	0	A	12493083	A	A	12493083	3	1	64	1	0	0	0	0	1	0	0	0	15137	1145	40	1	1133	1	SPIRE1	18	12493083	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	9425616	12493083	65584165	103	12807											
LMAN1	3998	broad.mit.edu	37	chr18	57026573	57026574	+	5'Flank	INS	-	C	C																															gattggcagagcccgggggaINScccccaagggcaaggggtga																								rs140141851	by1000genomes	TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr18:57026573_57026574insC	uc002lhz.2	-						LMAN1_uc010xek.1_5'Flank	NM_005570	NP_005561	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1 precursor						blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	AGCCCGGGGGACCCCCAAGGGC	0.752													---	---	---								C	57026574	C	C	57026573	6	5	64	0	1	1	1	0	0	0	0	0	8878	290	10	0		0	LMAN1	18	57026573	5'Flank	INS	-	TCGA-CN-5367-01A-01D-1434-08	44533490	57026573	21050675	104	12808											
SALL3	27164	broad.mit.edu	37	chr18	76754699	76754699	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccgagtcctcgtcctcgcAggccctgtcgccggccccca	3	7	11	20	5	0	0	0	0	0	0	6	1	3	0	7	2	0	1	7	2	0	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr18:76754699A>G	uc002lmt.2	+	2	2708	c.2708A>G	c.(2707-2709)CAG>CGG	p.Q903R	SALL3_uc010dra.2_Missense_Mutation_p.Q510R	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	903					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TCGTCCTCGCAGGCCCTGTCG	0.726													4	10					0	0	0	0	G	76754699	G	G	76754699	3	3	64	1	0	0	0	0	1	0	0	0	13877	188	7	5	2714	5	SALL3	18	76754699	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	19728126	76754699	1322549	105	12809											
PDE4C	5143	broad.mit.edu	37	chr19	18322001	18322001	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actctcgattgtcctccagcGtgtccagcaggtcctgtgca	6	11	10	14	2	1	0	0	0	1	0	6	1	5	0	4	1	3	2	4	1	0	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr19:18322001G>A	uc010xqc.1	-	15	2357	c.1877C>T	c.(1876-1878)ACG>ATG	p.T626M	PDE4C_uc002nik.3_Missense_Mutation_p.T626M|PDE4C_uc002nil.3_Missense_Mutation_p.T626M|PDE4C_uc002nif.3_Missense_Mutation_p.T395M|PDE4C_uc002nig.3_Missense_Mutation_p.T341M|PDE4C_uc002nih.3_Missense_Mutation_p.T396M|PDE4C_uc010ebk.2_Missense_Mutation_p.T520M|PDE4C_uc002nii.3_Missense_Mutation_p.T594M|PDE4C_uc010ebl.2_Missense_Mutation_p.T340M	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	626					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	GTCCTCCAGCGTGTCCAGCAG	0.597													7	108					0	0	0	0	A	18322001	A	A	18322001	3	1	64	1	0	0	0	0	1	0	0	0	11695	1145	40	1	265	1	PDE4C	19	18322001	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08		18322001	40806982	106	12810											
ZNF536	9745	broad.mit.edu	37	chr19	31040060	31040060	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcctccaagggggagaacaaCgatgaagaggatgttgaaac	15	6	13	7	1	0	4	0	2	0	2	2	7	2	5	2	3	3	1	2	3	5	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr19:31040060C>T	uc002nsu.1	+	4	3672	c.3534C>T	c.(3532-3534)AAC>AAT	p.N1178N	ZNF536_uc010edd.1_Silent_p.N1178N	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGGAGAACAACGATGAAGAGG	0.552													15	44					0	0	0	0	T	31040060	T	T	31040060	2	4	64	1	0	0	0	0	0	0	0	1	18041	535	19	1		1	ZNF536	19	31040060	Silent	SNP	C	TCGA-CN-5367-01A-01D-1434-08	12718059	31040060	28088923	107	12811											
SPRED3	399473	broad.mit.edu	37	chr19	38882740	38882740	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcctgctggctgcgctggCcgcactgggtcgaggtgagc	4	7	18	12	3	0	1	0	1	0	0	1	3	0	1	2	4	4	4	2	4	0	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr19:38882740C>A	uc002oim.2	+	2	336	c.332C>A	c.(331-333)GCC>GAC	p.A111D	SPRED3_uc002oil.1_Missense_Mutation_p.A111D	NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	111	WH1.				multicellular organismal development					central_nervous_system(2)|lung(1)|skin(1)	4	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GCTGCGCTGGCCGCACTGGGT	0.607													39	88					4.92203e-23	5.61993e-23	1	0	A	38882740	A	A	38882740	3	1	64	1	0	0	0	0	1	0	0	0	15160	739	26	4	338	4	SPRED3	19	38882740	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	7842680	38882740	20246243	108	12812											
FPR1	2357	broad.mit.edu	37	chr19	52249293	52249293	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcagggccctctccagacTggcgggaagggcgtggatca	7	6	17	11	2	3	1	2	0	1	1	4	3	3	3	2	6	0	0	2	6	1	0			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr19:52249293T>C	uc002pxq.2	-	2	1050	c.955A>G	c.(955-957)AGT>GGT	p.S319G		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	319	Cytoplasmic (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CTCTCCAGACTGGCGGGAAGG	0.567													8	98					0	0	0	0	C	52249293	C	C	52249293	3	2	64	1	0	0	0	0	1	0	0	0	6072	1580	55	5	101	5	FPR1	19	52249293	Missense_Mutation	SNP	T	TCGA-CN-5367-01A-01D-1434-08	13366553	52249293	6879690	109	12813											
ZNF471	57573	broad.mit.edu	37	chr19	57027646	57027646	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatatttgtcacttcaggaCttagtgacattcaaggatgt	12	15	8	6	0	3	1	3	1	0	0	3	3	3	3	0	2	0	0	0	2	4	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr19:57027646C>G	uc002qnh.2	+	3	169	c.36C>G	c.(34-36)GAC>GAG	p.D12E		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	12					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		CACTTCAGGACTTAGTGACAT	0.398													27	90					0	0	0	0	G	57027646	G	G	57027646	3	3	64	1	0	0	0	0	1	0	0	0	17997	564	20	4	42	4	ZNF471	19	57027646	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	4778353	57027646	2101337	110	12814											
PLCB4	5332	broad.mit.edu	37	chr20	9388620	9388620	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatcttataaatatgtaggTgctaccactaatatccatcc	13	13	5	10	0	1	0	0	0	1	0	3	0	3	0	3	1	2	3	3	1	8	7			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr20:9388620T>C	uc002wnf.2	+	20	1804	c.1668T>C	c.(1666-1668)GGT>GGC	p.G556G	PLCB4_uc010gbw.1_Silent_p.G556G|PLCB4_uc010gbx.2_Silent_p.G568G|PLCB4_uc002wne.2_Silent_p.G556G|PLCB4_uc002wnh.2_Silent_p.G403G	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	556					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						AATATGTAGGTGCTACCACTA	0.423													44	130					0	0	0	0	C	9388620	C	C	9388620	2	2	64	1	0	0	0	0	0	0	0	1	12085	1683	59	5		5	PLCB4	20	9388620	Silent	SNP	T	TCGA-CN-5367-01A-01D-1434-08		9388620	53636900	111	12815											
FLRT3	23767	broad.mit.edu	37	chr20	14306474	14306474	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctatatgcacagttccttGagaagagcgatccattccta	11	12	8	10	1	0	2	0	1	0	2	3	4	3	2	3	0	3	3	3	0	4	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr20:14306474G>A	uc002wov.1	-	3	2146	c.1679C>T	c.(1678-1680)TCA>TTA	p.S560L	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.S560L	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	560	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		ACAGTTCCTTGAGAAGAGCGA	0.468													57	117					0	0	0	0	A	14306474	A	A	14306474	3	1	64	1	0	0	0	0	1	0	0	0	5972	1294	45	2	274	2	FLRT3	20	14306474	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	4917854	14306474	48719046	112	12816											
SEC23B	10483	broad.mit.edu	37	chr20	18485751	18485751	+	5'Flank	DEL	A	-	-																															taatacattgcctcattcagAaaaaaaaaaaaaaattagga																								rs74180905		TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr20:18485751delA	uc002wqz.1	+						SEC23B_uc002wra.1_5'Flank|SEC23B_uc002wrb.1_5'Flank|SEC23B_uc010zsb.1_5'Flank|SEC23B_uc002wrc.1_5'Flank	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B						ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						CCTCATTCAGAAAAAAAAAAA	0.373													---	---	---								-	18485751	-	-	18485751	6	5	64	0	1	1	0	1	0	0	0	0	14057	261	9	0		0	SEC23B	20	18485751	5'Flank	DEL	A	TCGA-CN-5367-01A-01D-1434-08	4179277	18485751	44539769	113	12817											
PLK1S1	55857	broad.mit.edu	37	chr20	21143678	21143678	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaagatggaatagaggcCttaaaattaatccatgctga	16	9	11	5	0	0	4	0	1	0	3	1	6	1	5	2	3	1	1	2	3	6	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr20:21143678C>A	uc002wsb.2	+	6	1363	c.1230C>A	c.(1228-1230)GCC>GCA	p.A410A	PLK1S1_uc010zsh.1_Silent_p.A307A|PLK1S1_uc010zsi.1_Silent_p.A277A|PLK1S1_uc010zsj.1_RNA|uc002wsc.2_Intron|PLK1S1_uc002wsd.2_RNA	NM_018474	NP_060944	Q2M2Z5	KIZ_HUMAN	polo-like kinase 1 substrate 1 isoform 1	410					spindle organization	centrosome	protein kinase binding				0						GAATAGAGGCCTTAAAATTAA	0.408													20	39					5.35267e-07	5.80821e-07	1	0	A	21143678	A	A	21143678	2	1	64	1	0	0	0	0	0	0	0	1	12150	668	24	4		4	PLK1S1	20	21143678	Silent	SNP	C	TCGA-CN-5367-01A-01D-1434-08	2657927	21143678	41881842	114	12818											
PYGB	5834	broad.mit.edu	37	chr20	25276260	25276260	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttcaaggtgtttgcagactAtgaagcctacatgcagtgcc	10	11	11	9	0	1	2	1	1	0	1	1	2	1	2	2	1	5	4	2	1	4	4			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr20:25276260A>G	uc002wup.2	+	19	2442	c.2333A>G	c.(2332-2334)TAT>TGT	p.Y778C	ABHD12_uc002wuq.2_Intron|ABHD12_uc002wur.2_Intron	NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	778					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	TTTGCAGACTATGAAGCCTAC	0.632													22	88					0	0	0	0	G	25276260	G	G	25276260	3	3	64	1	0	0	0	0	1	0	0	0	12925	449	16	5	2407	5	PYGB	20	25276260	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08	4132582	25276260	37749260	115	12819											
NFATC2	4773	broad.mit.edu	37	chr20	50140011	50140011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggcaaccaaggcctcggCgcacgaatgcctccgcttgg	8	5	13	15	4	0	0	0	0	0	0	2	1	1	0	4	4	2	3	4	4	3	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr20:50140011C>T	uc002xwd.2	-	2	989	c.769G>A	c.(769-771)GCC>ACC	p.A257T	NFATC2_uc002xwc.2_Missense_Mutation_p.A257T|NFATC2_uc010zyv.1_Missense_Mutation_p.A38T|NFATC2_uc010zyw.1_Missense_Mutation_p.A38T|NFATC2_uc010zyx.1_Missense_Mutation_p.A237T|NFATC2_uc010zyy.1_Missense_Mutation_p.A38T|NFATC2_uc010zyz.1_Missense_Mutation_p.A38T|NFATC2_uc002xwe.2_Missense_Mutation_p.A237T	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	257	3 X approximate SP repeats.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					AAGGCCTCGGCGCACGAATGC	0.741													9	36					0	0	0	0	T	50140011	T	T	50140011	3	4	64	1	0	0	0	0	1	0	0	0	10416	768	27	1	2092	1	NFATC2	20	50140011	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	24863751	50140011	12885509	116	12820											
DIDO1	11083	broad.mit.edu	37	chr20	61510637	61510637	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctcgaggcctcgggcttcGggtcccgagcgctctctttg	2	10	13	16	5	1	0	0	0	1	0	6	2	2	0	3	3	1	2	3	3	0	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr20:61510637G>C	uc002ydr.1	-	16	6935	c.6671C>G	c.(6670-6672)CCG>CGG	p.P2224R	DIDO1_uc002yds.1_Missense_Mutation_p.P2224R	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	2224					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTCGGGCTTCGGGTCCCGAGC	0.483													3	13					0	0	0	0	C	61510637	C	C	61510637	3	2	64	1	0	0	0	0	1	0	0	0	4544	1116	39	3	55	3	DIDO1	20	61510637	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	11370626	61510637	1514883	117	12821											
YTHDF1	54915	broad.mit.edu	37	chr20	61834905	61834905	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacttgtcccccatgctgaGaacgcagggttttcagggaa	9	9	11	12	1	1	1	1	1	0	1	2	3	2	2	3	2	2	3	3	2	2	3			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr20:61834905G>C	uc002yeh.2	-	4	681	c.387C>G	c.(385-387)TTC>TTG	p.F129L	YTHDF1_uc011aaq.1_Missense_Mutation_p.F79L	NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	129										ovary(2)	2						CCCATGCTGAGAACGCAGGGT	0.567													20	50					0	0	0	0	C	61834905	C	C	61834905	3	2	64	1	0	0	0	0	1	0	0	0	17566	933	33	2	1300	2	YTHDF1	20	61834905	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	324268	61834905	1190615	118	12822											
KRTAP10-6	386674	broad.mit.edu	37	chr21	46011993	46011993	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacagcagacggacacacAgcacacaggcttgcagcaga	14	2	10	15	1	0	2	0	0	0	2	0	3	0	3	1	2	4	5	1	2	0	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chr21:46011993A>C	uc002zfm.2	-	1	394	c.373T>G	c.(373-375)TGT>GGT	p.C125G	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198688	NP_941961	P60371	KR106_HUMAN	keratin associated protein 10-6	125	29 X 5 AA repeats of C-C-X(3).|9.					keratin filament					0						ACGGACACACAGCACACAGGC	0.642													6	63					0	0	0	0	C	46011993	C	C	46011993	3	2	64	1	0	0	0	0	1	0	0	0	8552	188	7	5	728	5	KRTAP10-6	21	46011993	Missense_Mutation	SNP	A	TCGA-CN-5367-01A-01D-1434-08		46011993	2117902	119	12823											
PHKA2	5256	broad.mit.edu	37	chrX	18924612	18924612	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggagctgcgggcatctcaCctgagcagttcaggctccgt	7	8	13	13	2	2	1	2	1	1	0	4	2	3	2	2	3	3	5	2	3	0	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chrX:18924612C>T	uc004cyv.3	-	25	3236	c.2806_splice	c.e25+1	p.G936_splice	PHKA2_uc004cyu.3_Splice_Site_p.G234_splice|PHKA2_uc010nfe.1_5'Flank|PHKA2_uc010nff.1_5'Flank	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)						glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					GGGCATCTCACCTGAGCAGTT	0.627													24	55					0	0	0	0	T	18924612	T	T	18924612	5	4	64	1	0	0	0	0	0	0	1	0	11899	521	18	4	936	4	PHKA2	23	18924612	Splice_Site	SNP	C	TCGA-CN-5367-01A-01D-1434-08		18924612	136345948	120	12824											
PTCHD1	139411	broad.mit.edu	37	chrX	23398142	23398142	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcactgagggaagatttccaGaagaccagccgcgtatcaga	13	7	11	10	2	2	5	2	1	0	4	3	6	3	6	3	1	1	1	3	1	3	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chrX:23398142G>T	uc004dal.3	+	2	794	c.786G>T	c.(784-786)CAG>CAT	p.Q262H	PTCHD1_uc010nfu.1_Missense_Mutation_p.Q262H	NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	262					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						AAGATTTCCAGAAGACCAGCC	0.522													36	173					9.04072e-19	1.02461e-18	1	0	T	23398142	T	T	23398142	3	4	64	1	0	0	0	0	1	0	0	0	12794	933	33	2	792	2	PTCHD1	23	23398142	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	4473530	23398142	131872418	121	12825											
WNK3	65267	broad.mit.edu	37	chrX	54334451	54334451	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atacacattccaaaagcataAacatctacggattcatcata	18	10	3	10	1	3	0	2	0	1	0	4	1	4	1	1	1	4	1	1	1	7	6			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chrX:54334451A>G	uc004dtd.1	-	5	1432	c.993T>C	c.(991-993)GTT>GTC	p.V331V	WNK3_uc004dtc.1_Silent_p.V331V	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	331	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						CAAAAGCATAAACATCTACGG	0.398													7	75					0	0	0	0	G	54334451	G	G	54334451	2	3	64	1	0	0	0	0	0	0	0	1	17447	1	1	5		5	WNK3	23	54334451	Silent	SNP	A	TCGA-CN-5367-01A-01D-1434-08	30936309	54334451	100936109	122	12826											
SLC16A2	6567	broad.mit.edu	37	chrX	73740906	73740906	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactgaccgtttgggctgccGaatcacagcaaccgcggggg	8	6	14	13	4	1	1	1	1	0	0	1	2	1	1	3	3	3	3	3	3	2	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chrX:73740906G>A	uc004ebt.2	+	2	900	c.734G>A	c.(733-735)CGA>CAA	p.R245Q		NM_006517	NP_006508	P36021	MOT8_HUMAN	solute carrier family 16, member 2	171	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|ovary(1)	3					Pyruvic acid(DB00119)	TTGGGCTGCCGAATCACAGCA	0.537													6	85					0	0	0	0	A	73740906	A	A	73740906	3	1	64	1	0	0	0	0	1	0	0	0	14473	1058	37	1	740	1	SLC16A2	23	73740906	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	19406455	73740906	81529654	123	12827											
CYLC1	1538	broad.mit.edu	37	chrX	83128622	83128622	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgatgctgaatctgaagaCtcaaaggatgctaagaaaga	16	9	10	6	0	3	6	1	3	2	3	3	7	3	7	0	1	2	2	0	1	5	1			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chrX:83128622C>G	uc004eei.1	+	4	927	c.906C>G	c.(904-906)GAC>GAG	p.D302E	CYLC1_uc004eeh.1_Missense_Mutation_p.D301E	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	302	1.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						AATCTGAAGACTCAAAGGATG	0.323													10	52					0	0	0	0	G	83128622	G	G	83128622	3	3	64	1	0	0	0	0	1	0	0	0	4158	564	20	4	920	4	CYLC1	23	83128622	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	9387716	83128622	72141938	124	12828											
SPANXC	64663	broad.mit.edu	37	chrX	140336770	140336771	+	5'Flank	INS	-	G	G																															ggcagccctagggtggcttcINSacatcacaaagccccactgc																										TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chrX:140336770_140336771insG	uc004fbk.2	-						SPANXC_uc004fbl.2_Intron	NM_022661	NP_073152	Q9NY87	SPNXC_HUMAN	sperm protein associated with the nucleus, X							cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					AGGGTGGCTTCACATCACAAAG	0.559													---	---	---								G	140336771	G	G	140336770	6	5	64	0	1	1	1	0	0	0	0	0	15053	841	29	0		0	SPANXC	23	140336770	5'Flank	INS	-	TCGA-CN-5367-01A-01D-1434-08	57208148	140336770	14933790	125	12829											
SPANXE	171489	broad.mit.edu	37	chrX	140786553	140786553	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caccccgccggcactggattGtttgtccattgtatatattg	7	14	9	11	2	0	0	0	0	0	0	1	1	1	1	4	2	0	3	4	2	3	7			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chrX:140786553G>T	uc004fbq.2	-	1	103	c.10C>A	c.(10-12)CAA>AAA	p.Q4K		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	SPANX family, member E	4						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					GCACTGGATTGTTTGTCCATT	0.433													43	184					3.37043e-27	3.87726e-27	1	0	T	140786553	T	T	140786553	3	4	64	1	0	0	0	0	1	0	0	0	15055	1386	48	4	291	4	SPANXE	23	140786553	Missense_Mutation	SNP	G	TCGA-CN-5367-01A-01D-1434-08	449783	140786553	14484007	126	12830											
FMR1	2332	broad.mit.edu	37	chrX	147026445	147026445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatctgaccacagagacgaaCtcagtgattggtcattagct	13	10	9	9	1	3	3	2	2	1	1	3	5	3	3	1	1	2	1	1	1	3	2			TCGA-CN-5367-01A-01D-1434-08	TCGA-CN-5367-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	57adb398-48c5-4a14-a43e-f79a19befbda	3c6ca4c1-7112-4c0c-9d21-b00717fcd4de	g.chrX:147026445C>T	uc010nst.2	+	15	1717	c.1528C>T	c.(1528-1530)CTC>TTC	p.L510F	FMR1_uc004fcj.2_Missense_Mutation_p.L487F|FMR1_uc004fck.3_Intron|FMR1_uc004fcl.3_Missense_Mutation_p.L350F|FMR1_uc011mxa.1_Missense_Mutation_p.L157F	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	510	Interaction with RANBP9.				mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAGAGACGAACTCAGTGATTG	0.388									Fragile_X_syndrome				3	59					0	0	0	0	T	147026445	T	T	147026445	3	4	64	1	0	0	0	0	1	0	0	0	5992	565	20	4	1586	4	FMR1	23	147026445	Missense_Mutation	SNP	C	TCGA-CN-5367-01A-01D-1434-08	6239892	147026445	8244115	127	12831											
NPHP4	261734	broad.mit.edu	37	chr1	5964821	5964822	+	Frame_Shift_Del	DEL	AC	-	-																															gtagaactggaaggtgaaatAcacagtctttggccatgatg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:5964821_5964822delAC	uc001alq.1	-	16	2264_2265	c.1998_1999delGT	c.(1996-2001)GTGTATfs	p.V666fs	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_RNA|NPHP4_uc001alt.1_RNA|NPHP4_uc009vlu.1_RNA	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	666_667					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		AAGGTGAAATACACAGTCTTTG	0.589													---	---	---								-	5964822	-	-	5964821	7	5	65	1	0	1	0	1	0	0	0	0	10635	391	14	0	2341	0	NPHP4	1	5964821	Frame_Shift_Del	DEL	AC	TCGA-CN-5369-01A-01D-1434-08		5964821	243285800	1	12832											
PHF13	148479	broad.mit.edu	37	chr1	6680128	6680128	+	Frame_Shift_Del	DEL	G	-	-																															gcctgggaaagaggggtacaGggggggcttgctgaagctgg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:6680128delG	uc001aob.3	+	3	778	c.407delG	c.(406-408)AGGfs	p.R136fs		NM_153812	NP_722519	Q86YI8	PHF13_HUMAN	PHD finger protein 13	136					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		GAGGGGTACAGGGGGGGCTTG	0.522													---	---	---								-	6680128	-	-	6680128	7	5	65	1	0	1	0	1	0	0	0	0	11879	1000	35	0	417	0	PHF13	1	6680128	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	715307	6680128	242570493	2	12833											
RERE	473	broad.mit.edu	37	chr1	8674637	8674637	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacccctacaggccctctccCggcttcagaaagatgctgtg	8	9	9	15	1	2	2	1	0	1	2	3	2	2	2	4	2	3	2	4	2	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:8674637C>T	uc001ape.2	-	5	1315	c.505G>A	c.(505-507)GGG>AGG	p.G169R	RERE_uc001apf.2_Missense_Mutation_p.G169R|RERE_uc001aph.1_Missense_Mutation_p.G169R	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	169	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GGCCCTCTCCCGGCTTCAGAA	0.507													13	183					0	0	0	0	T	8674637	T	T	8674637	3	4	65	1	0	0	0	0	1	0	0	0	13296	652	23	1	4275	1	RERE	1	8674637	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1994509	8674637	240575984	3	12834											
PEX14	5195	broad.mit.edu	37	chr1	10659377	10659377	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtccttgggcccagccacAcaggtggttcctgtccagcc	5	9	11	16	1	0	0	0	0	0	0	4	0	3	0	6	3	2	1	6	3	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:10659377A>C	uc001arn.2	+	4	273	c.252A>C	c.(250-252)ACA>ACC	p.T84T	PEX14_uc009vmu.1_Intron|PEX14_uc009vmv.2_Silent_p.T20T|PEX14_uc010oam.1_Silent_p.T20T|PEX14_uc010oan.1_Intron|PEX14_uc009vmw.2_Silent_p.T20T	NM_004565	NP_004556	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	84					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(1)	1	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		GCCCAGCCACACAGGTGGTTC	0.557													10	157					0	0	0	0	C	10659377	C	C	10659377	2	2	65	1	0	0	0	0	0	0	0	1	11797	146	6	5		5	PEX14	1	10659377	Silent	SNP	A	TCGA-CN-5369-01A-01D-1434-08	1984740	10659377	238591244	4	12835											
TARDBP	23435	broad.mit.edu	37	chr1	11073908	11073908	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttccaggggcgtgtgggcttCgctacaggaatccagtgtct	6	11	14	10	2	1	0	0	0	1	0	4	1	3	1	2	4	1	2	2	4	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:11073908C>T	uc001art.2	+	2	258	c.124C>T	c.(124-126)CGC>TGC	p.R42C	TARDBP_uc010oap.1_5'UTR	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	42					3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		GTGTGGGCTTCGCTACAGGAA	0.542													11	90					0	0	0	0	T	11073908	T	T	11073908	3	4	65	1	0	0	0	0	1	0	0	0	15623	884	31	1	126	1	TARDBP	1	11073908	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	414531	11073908	238176713	5	12836											
AADACL3	126767	broad.mit.edu	37	chr1	12785336	12785336	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttcggaggggcaatagcCgcagtggtttgtcaacaact	10	10	13	8	2	1	0	1	0	0	0	2	1	1	1	1	4	3	4	1	4	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:12785336C>A	uc009vnn.1	+	4	659	c.426C>A	c.(424-426)GCC>GCA	p.A142A	AADACL3_uc001aug.1_Silent_p.A72A	NM_001103170	NP_001096640	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3 isoform 1	142							hydrolase activity				0	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCAATAGCCGCAGTGGTTT	0.567													12	154					7.03913e-09	7.51798e-09	1	0	A	12785336	A	A	12785336	2	1	65	1	0	0	0	0	0	0	0	1	12	639	23	3		3	AADACL3	1	12785336	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1711428	12785336	236465285	6	12837											
NIPAL3	57185	broad.mit.edu	37	chr1	24779986	24779986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgattcttctcttggtggCgttacttggtaagttggcat	5	17	12	7	2	2	1	0	1	2	0	3	1	2	1	0	4	1	4	0	4	2	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:24779986C>T	uc001bjh.2	+	7	1036	c.629C>T	c.(628-630)GCG>GTG	p.A210V	NIPAL3_uc010oek.1_Missense_Mutation_p.A210V|NIPAL3_uc001bjg.2_Missense_Mutation_p.A210V|NIPAL3_uc009vrc.2_Missense_Mutation_p.A128V|NIPAL3_uc001bji.2_5'Flank	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	210	Helical; (Potential).					integral to membrane					0						CTCTTGGTGGCGTTACTTGGT	0.483													6	56					0	0	0	0	T	24779986	T	T	24779986	3	4	65	1	0	0	0	0	1	0	0	0	10480	768	27	1	651	1	NIPAL3	1	24779986	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	11994650	24779986	224470635	7	12838											
CATSPER4	378807	broad.mit.edu	37	chr1	26520297	26520297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaacactatgagttgttctCtaccatagatgacattgtgc	12	13	8	8	0	1	3	0	2	1	1	2	4	1	3	1	0	3	2	1	0	4	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:26520297C>T	uc010oez.1	+	3	377	c.377C>T	c.(376-378)TCT>TTT	p.S126F	CATSPER4_uc010oey.1_5'UTR|CATSPER4_uc009vsf.2_RNA	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	126	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		GAGTTGTTCTCTACCATAGAT	0.507													27	227					0	0	0	0	T	26520297	T	T	26520297	3	4	65	1	0	0	0	0	1	0	0	0	2702	913	32	2	387	2	CATSPER4	1	26520297	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1740311	26520297	222730324	8	12839											
WDTC1	23038	broad.mit.edu	37	chr1	27614167	27614167	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tccatttctcctatatagttCctgcctcacgctggggaccg	6	13	8	14	2	2	0	1	0	1	0	5	1	4	1	5	2	1	2	5	2	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:27614167C>G	uc009vst.2	+	6	829	c.294C>G	c.(292-294)TTC>TTG	p.F98L	WDTC1_uc001bno.2_Missense_Mutation_p.F98L|WDTC1_uc001bnp.1_RNA	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	98	WD 2.						protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		CTATATAGTTCCTGCCTCACG	0.542													3	31					0	0	0	0	G	27614167	G	G	27614167	3	3	65	1	0	0	0	0	1	0	0	0	17410	854	30	2	312	2	WDTC1	1	27614167	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1093870	27614167	221636454	9	12840											
AHDC1	27245	broad.mit.edu	37	chr1	27874901	27874901	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagcccagatgtgaggcctcGaacaggtccaccttcttccg	9	8	10	14	2	1	2	0	1	1	1	4	3	3	2	5	2	2	0	5	2	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:27874901G>A	uc009vsy.2	-	6	4695	c.3726C>T	c.(3724-3726)TTC>TTT	p.F1242F	AHDC1_uc009vsz.1_Silent_p.F1242F	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1242							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GTGAGGCCTCGAACAGGTCCA	0.652													8	59					0	0	0	0	A	27874901	A	A	27874901	2	1	65	1	0	0	0	0	0	0	0	1	412	1049	37	1		1	AHDC1	1	27874901	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	260734	27874901	221375720	10	12841											
SDC3	9672	broad.mit.edu	37	chr1	31347180	31347180	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgctccaggatactcttctGaggcagctgagcagctgagc	8	8	12	13	1	2	3	0	3	2	0	3	4	3	4	2	2	5	5	2	2	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:31347180G>A	uc001bse.2	-	4	1173	c.1126C>T	c.(1126-1128)CAG>TAG	p.Q376*	SDC3_uc001bsd.2_Nonsense_Mutation_p.Q318*	NM_014654	NP_055469	O75056	SDC3_HUMAN	syndecan 3	376	Extracellular (Potential).					integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		ATACTCTTCTGAGGCAGCTGA	0.652													7	52					0	0	0	0	A	31347180	A	A	31347180	4	1	65	1	0	0	0	0	0	1	0	0	14018	1299	45	2	210	2	SDC3	1	31347180	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3472279	31347180	217903441	11	12842											
HCRTR1	3061	broad.mit.edu	37	chr1	32085276	32085276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcactgagtcctggctgttcGgccatgccctctgcaaggtc	5	11	11	14	1	2	1	1	1	1	0	5	1	3	1	3	3	2	3	3	3	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:32085276G>A	uc009vtx.2	+	4	728	c.343G>A	c.(343-345)GGC>AGC	p.G115S	HCRTR1_uc001btb.2_Intron|HCRTR1_uc001btc.3_Intron|HCRTR1_uc001btd.2_Missense_Mutation_p.G115S|HCRTR1_uc010ogl.1_Missense_Mutation_p.G115S	NM_001525	NP_001516	O43613	OX1R_HUMAN	orexin receptor 1	115	Extracellular (Potential).				feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				ovary(1)	1		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		CTGGCTGTTCGGCCATGCCCT	0.582													7	52					0	0	0	0	A	32085276	A	A	32085276	3	1	65	1	0	0	0	0	1	0	0	0	7040	1116	39	1	349	1	HCRTR1	1	32085276	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	738096	32085276	217165345	12	12843											
EIF2C3	192669	broad.mit.edu	37	chr1	36520550	36520550	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattgccttctctatagggtAccagtcgtccttcacactat	8	14	6	13	1	2	0	1	0	1	0	5	0	3	0	3	1	2	1	3	1	4	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:36520550A>G	uc001bzp.2	+	18	2534	c.2278A>G	c.(2278-2280)ACC>GCC	p.T760A	EIF2C3_uc001bzq.2_Missense_Mutation_p.T526A	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	760	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TCTATAGGGTACCAGTCGTCC	0.308													10	149					0	0	0	0	G	36520550	G	G	36520550	3	3	65	1	0	0	0	0	1	0	0	0	5029	391	14	5	2348	5	EIF2C3	1	36520550	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	4435274	36520550	212730071	13	12844											
FOXJ3	22887	broad.mit.edu	37	chr1	42655054	42655054	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttttagcatatcaagtgtcGcataccaatcatttgaaaca	14	13	5	9	1	2	1	2	1	0	0	3	1	2	1	1	0	3	2	1	0	6	5	rs61753350		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:42655054G>A	uc001che.2	-	12	1685	c.1373C>T	c.(1372-1374)GCG>GTG	p.A458V	FOXJ3_uc001chf.2_Missense_Mutation_p.A458V|FOXJ3_uc001chg.2_Missense_Mutation_p.A458V	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	458					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATCAAGTGTCGCATACCAATC	0.403													7	67					0	0	0	0	A	42655054	A	A	42655054	3	1	65	1	0	0	0	0	1	0	0	0	6047	1087	38	1	511	1	FOXJ3	1	42655054	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6134504	42655054	206595567	14	12845											
EIF2B3	8891	broad.mit.edu	37	chr1	45341334	45341334	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacgaatggactggtggttCttctggacagagagcagaca	11	9	14	7	1	2	3	0	1	2	2	2	7	2	5	0	4	1	2	0	4	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:45341334C>G	uc001cmt.1	-	9	1136	c.1009G>C	c.(1009-1011)GAA>CAA	p.E337Q	EIF2B3_uc001cmu.1_Missense_Mutation_p.E337Q|EIF2B3_uc001cmv.1_Intron|EIF2B3_uc001cmw.2_Missense_Mutation_p.E337Q	NM_020365	NP_065098	Q9NR50	EI2BG_HUMAN	eukaryotic translation initiation factor 2B,	337					negative regulation of translational initiation in response to stress|oligodendrocyte development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	nucleotidyltransferase activity|protein binding|translation initiation factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACTGGTGGTTCTTCTGGACAG	0.448													5	80					0	0	0	0	G	45341334	G	G	45341334	3	3	65	1	0	0	0	0	1	0	0	0	5024	922	32	2	402	2	EIF2B3	1	45341334	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2686280	45341334	203909287	15	12846											
POMGNT1	55624	broad.mit.edu	37	chr1	46655573	46655573	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcatcatctttctccattcGaataaaggccacgtaggtgt	10	13	8	10	2	4	0	2	0	2	0	6	1	4	0	2	2	0	1	2	2	4	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:46655573G>A	uc001cpe.2	-	20	1902	c.1738C>T	c.(1738-1740)CGA>TGA	p.R580*	POMGNT1_uc010olx.1_Nonsense_Mutation_p.R558*|POMGNT1_uc010oly.1_RNA|POMGNT1_uc010olz.1_Nonsense_Mutation_p.R437*|POMGNT1_uc001cpg.2_Nonsense_Mutation_p.R580*|POMGNT1_uc001cpf.2_Nonsense_Mutation_p.R247*	NM_017739	NP_060209	Q8WZA1	PMGT1_HUMAN	O-linked mannose	580	Lumenal (Potential).				protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TTCTCCATTCGAATAAAGGCC	0.547													6	56					0	0	0	0	A	46655573	A	A	46655573	4	1	65	1	0	0	0	0	0	1	0	0	12298	1066	37	1	256	1	POMGNT1	1	46655573	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1314239	46655573	202595048	16	12847											
SLC5A9	200010	broad.mit.edu	37	chr1	48703350	48703350	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccctgtgctctctctggcaGagtgtttgtggtgttcctgg	2	15	14	10	0	2	1	0	0	2	1	4	1	3	1	2	3	1	4	2	3	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:48703350G>A	uc001cro.2	+	11	1345	c.1293_splice	c.e11-1	p.R431_splice	SLC5A9_uc010oms.1_Splice_Site|SLC5A9_uc001crn.2_Splice_Site_p.R456_splice|SLC5A9_uc010omt.1_Splice_Site_p.R445_splice|SLC5A9_uc001crp.2_Splice_Site_p.R98_splice|SLC5A9_uc010omu.1_Splice_Site_p.R98_splice|SLC5A9_uc009vyt.1_5'Flank	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose							integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						CTCTCTGGCAGAGTGTTTGTG	0.567													6	98					0	0	0	0	A	48703350	A	A	48703350	5	1	65	1	0	0	0	0	0	0	1	0	14736	956	33	2	1413	2	SLC5A9	1	48703350	Splice_Site	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2047777	48703350	200547271	17	12848											
MRPL37	51253	broad.mit.edu	37	chr1	54681872	54681872	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcgtgggcacggatggacGtgtcttccatttcctagtgt	6	12	14	9	3	1	0	0	0	1	0	3	3	3	2	2	3	1	1	2	3	1	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:54681872G>A	uc001cxa.3	+	6	1126	c.1049G>A	c.(1048-1050)CGT>CAT	p.R350H	MRPL37_uc009vzp.2_Missense_Mutation_p.R219H|MRPL37_uc001cxb.1_Missense_Mutation_p.R350H|MRPL37_uc001cxc.3_Missense_Mutation_p.R38H|MRPL37_uc010oob.1_RNA	NM_016491	NP_057575	Q9BZE1	RM37_HUMAN	mitochondrial ribosomal protein L37 precursor	350					translation	mitochondrial ribosome	structural constituent of ribosome				0						ACGGATGGACGTGTCTTCCAT	0.517													22	206					0	0	0	0	A	54681872	A	A	54681872	3	1	65	1	0	0	0	0	1	0	0	0	9853	1145	40	1	1071	1	MRPL37	1	54681872	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	5978522	54681872	194568749	18	12849											
USP24	23358	broad.mit.edu	37	chr1	55561055	55561055	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagtatcttcggcgcacatCagtgtatgggtttgctttat	7	15	10	9	2	2	0	1	0	1	0	3	0	2	0	1	2	1	5	1	2	3	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:55561055C>T	uc001cyg.3	-	48	5596	c.5596G>A	c.(5596-5598)GAT>AAT	p.D1866N		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	2026					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						CGGCGCACATCAGTGTATGGG	0.388													4	39					0	0	0	0	T	55561055	T	T	55561055	3	4	65	1	0	0	0	0	1	0	0	0	17123	826	29	2	1858	2	USP24	1	55561055	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	879183	55561055	193689566	19	12850											
PDE4B	5142	broad.mit.edu	37	chr1	66827446	66827446	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcatctcacgctttggagtCaacactgaaaatgaagatca	15	9	8	9	1	3	3	3	2	1	1	4	4	3	4	0	1	2	2	0	1	4	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:66827446C>G	uc001dcn.2	+	10	1181	c.990C>G	c.(988-990)GTC>GTG	p.V330V	PDE4B_uc009war.2_Silent_p.V238V|PDE4B_uc001dco.2_Silent_p.V330V|PDE4B_uc001dcp.2_Silent_p.V315V|PDE4B_uc001dcq.2_Silent_p.V158V|PDE4B_uc009was.2_Silent_p.V97V	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	330					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	GCTTTGGAGTCAACACTGAAA	0.418													7	84					0	0	0	0	G	66827446	G	G	66827446	2	3	65	1	0	0	0	0	0	0	0	1	11694	813	29	2		2	PDE4B	1	66827446	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	11266391	66827446	182423175	20	12851											
C1orf141	400757	broad.mit.edu	37	chr1	67592911	67592911	+	Frame_Shift_Del	DEL	T	-	-																															gacatccaacttctctaggaTtttttctgccattgtcaatc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:67592911delT	uc001ddl.1	-	2	124	c.13delA	c.(13-15)ATCfs	p.I5fs	C1orf141_uc001ddm.1_Frame_Shift_Del_p.I5fs|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	5										ovary(1)	1						TTCTCTAGGATTTTTTCTGCC	0.313													---	---	---								-	67592911	-	-	67592911	7	5	65	1	0	1	0	1	0	0	0	0	2010	1493	52	0	1213	0	C1orf141	1	67592911	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	765465	67592911	181657710	21	12852											
GNG12	55970	broad.mit.edu	37	chr1	68171151	68171151	+	Frame_Shift_Del	DEL	T	-	-																															ccactataagatgatgcaagTttttttatccttgaaagggt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:68171151delT	uc001dea.1	-	4	394	c.202delA	c.(202-204)ACTfs	p.T68fs		NM_018841	NP_061329	Q9UBI6	GBG12_HUMAN	G-protein gamma-12 subunit precursor	68					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0						ATGATGCAAGTTTTTTTATCC	0.438													---	---	---								-	68171151	-	-	68171151	7	5	65	1	0	1	0	1	0	0	0	0	6562	1725	60	0	20	0	GNG12	1	68171151	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	578240	68171151	181079470	22	12853											
SH3GLB1	51100	broad.mit.edu	37	chr1	87200333	87200333	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaatttgatcgtcaagcaGagattaccagacttctgcta	12	12	9	8	1	2	4	1	2	1	2	3	5	2	4	1	0	3	2	1	0	4	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:87200333G>A	uc001dlw.2	+	6	945	c.619G>A	c.(619-621)GAG>AAG	p.E207K	SH3GLB1_uc001dlx.2_Missense_Mutation_p.E228K|SH3GLB1_uc001dly.2_Missense_Mutation_p.E236K|SH3GLB1_uc001dlz.2_Missense_Mutation_p.E107K	NM_016009	NP_057093	Q9Y371	SHLB1_HUMAN	SH3-containing protein SH3GLB1	207	BAR.				anti-apoptosis|filopodium assembly|signal transduction	Golgi membrane|mitochondrial outer membrane	cytoskeletal adaptor activity|protein homodimerization activity|SH3 domain binding				0		Lung NSC(277;0.209)		all cancers(265;0.0136)|Epithelial(280;0.0414)		TCGTCAAGCAGAGATTACCAG	0.353													7	74					0	0	0	0	A	87200333	A	A	87200333	3	1	65	1	0	0	0	0	1	0	0	0	14318	943	33	2	641	2	SH3GLB1	1	87200333	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	19029182	87200333	162050288	23	12854											
ZNF326	284695	broad.mit.edu	37	chr1	90459793	90459793	+	5'Flank	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcatccaagccattgcttGatgataatgttgccagtatc	10	14	8	9	0	0	2	0	2	0	0	2	2	1	2	3	0	4	4	3	0	3	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:90459793G>C	uc001dnq.2	+						GEMIN8P4_uc001dno.2_RNA|ZNF326_uc001dnp.3_5'Flank|ZNF326_uc009wda.1_5'Flank|ZNF326_uc001dnr.2_5'Flank	NM_182976	NP_892021	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			ovary(1)	1		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		GCCATTGCTTGATGATAATGT	0.478													10	119					0	0	0	0	C	90459793	C	C	90459793	1	2	65	0	1	0	0	0	0	0	0	0	17913	1305	45	2		2	ZNF326	1	90459793	5'Flank	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3259460	90459793	158790828	24	12855											
ATXN7L2	127002	broad.mit.edu	37	chr1	110030321	110030321	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcctggcagagagaacatcGagatcatccccagtgagggg	11	6	13	11	1	1	4	1	1	0	3	4	6	3	4	3	3	1	1	3	3	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:110030321G>A	uc001dxr.2	+	5	610	c.595G>A	c.(595-597)GAG>AAG	p.E199K	ATXN7L2_uc001dxs.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	199										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		AGAGAACATCGAGATCATCCC	0.597													21	182					0	0	0	0	A	110030321	A	A	110030321	3	1	65	1	0	0	0	0	1	0	0	0	1219	1059	37	1	613	1	ATXN7L2	1	110030321	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	19570528	110030321	139220300	25	12856											
EPS8L3	79574	broad.mit.edu	37	chr1	110301152	110301152	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgccccaaacttactgtgctCtagggtcctctggtggggct	5	12	12	12	0	2	0	0	0	2	0	3	0	3	0	3	4	4	2	3	4	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:110301152C>T	uc001dyr.1	-	7	740	c.595G>A	c.(595-597)GAG>AAG	p.E199K	EPS8L3_uc001dys.1_Missense_Mutation_p.E199K|EPS8L3_uc001dyq.1_Missense_Mutation_p.E200K|EPS8L3_uc009wfm.1_Missense_Mutation_p.E166K|EPS8L3_uc009wfn.1_Missense_Mutation_p.E166K|EPS8L3_uc009wfo.1_Missense_Mutation_p.E146K	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	199	Pro-rich.					cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		TTACTGTGCTCTAGGGTCCTC	0.577													12	144					0	0	0	0	T	110301152	T	T	110301152	3	4	65	1	0	0	0	0	1	0	0	0	5221	922	32	2	1238	2	EPS8L3	1	110301152	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	270831	110301152	138949469	26	12857											
KCNC4	3749	broad.mit.edu	37	chr1	110765834	110765834	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccccgacacgctggacttCgtcaagaacctgctcaacat	10	8	8	15	3	2	1	2	0	0	1	3	3	2	2	3	1	4	2	3	1	3	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:110765834C>T	uc001dzh.2	+	2	984	c.927C>T	c.(925-927)TTC>TTT	p.F309F	KCNC4_uc001dzf.2_Silent_p.F309F|KCNC4_uc009wfr.2_Silent_p.F309F|KCNC4_uc001dzg.2_Silent_p.F309F|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	309	Cytoplasmic (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGCTGGACTTCGTCAAGAACC	0.607													8	92					0	0	0	0	T	110765834	T	T	110765834	2	4	65	1	0	0	0	0	0	0	0	1	8056	883	31	1		1	KCNC4	1	110765834	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	464682	110765834	138484787	27	12858											
KCNA3	3738	broad.mit.edu	37	chr1	111216030	111216030	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgcgatggtcaagacacCggcgatggcacagagagatc	13	5	13	10	3	1	3	1	0	0	3	2	6	1	3	1	3	1	1	1	3	2	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:111216030C>T	uc001dzv.1	-	1	1626	c.1402G>A	c.(1402-1404)GGT>AGT	p.G468S		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	468	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity	p.G468S(1)		ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTCAAGACACCGGCGATGGCA	0.527													9	98					0	0	0	0	T	111216030	T	T	111216030	3	4	65	1	0	0	0	0	1	0	0	0	8043	652	23	1	329	1	KCNA3	1	111216030	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	450196	111216030	138034591	28	12859											
SYT6	148281	broad.mit.edu	37	chr1	114641761	114641761	+	Frame_Shift_Del	DEL	T	-	-																															gcaggctgacttgatccatgTtttccgggggaatgtcaaag																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:114641761delT	uc001eev.2	-	5	1314	c.1064delA	c.(1063-1065)AACfs	p.N355fs	SYT6_uc001eeu.2_5'UTR	NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	440	Cytoplasmic (Potential).|C2 2.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGATCCATGTTTTCCGGGGG	0.488													---	---	---								-	114641761	-	-	114641761	7	5	65	1	0	1	0	1	0	0	0	0	15544	1725	60	0	225	0	SYT6	1	114641761	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	3425731	114641761	134608860	29	12860											
SPAG17	200162	broad.mit.edu	37	chr1	118530499	118530499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagcgttttgaggatgctGtgtgtctatgtgaaaggaaa	10	13	13	5	1	1	2	0	2	1	0	2	4	2	4	1	2	2	2	1	2	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:118530499G>A	uc001ehk.2	-	40	5695	c.5627C>T	c.(5626-5628)ACA>ATA	p.T1876I		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1876	Potential.					cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TGAGGATGCTGTGTGTCTATG	0.388													5	75					0	0	0	0	A	118530499	A	A	118530499	3	1	65	1	0	0	0	0	1	0	0	0	15045	1377	48	4	1080	4	SPAG17	1	118530499	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3888738	118530499	130720122	30	12861											
C1orf56	54964	broad.mit.edu	37	chr1	151020330	151020330	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagagcccagccccatggtcCccgccgccggcgcgctgctg	5	4	13	19	5	0	1	0	0	0	1	1	1	1	1	7	2	3	2	7	2	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:151020330C>A	uc001ewn.2	+	1	72	c.7C>A	c.(7-9)CCC>ACC	p.P3T		NM_017860	NP_060330	Q9BUN1	CA056_HUMAN	hypothetical protein LOC54964 precursor	3						extracellular region					0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCCATGGTCCCCGCCGCCGG	0.711													4	28					2.56e-06	2.66614e-06	1	0	A	151020330	A	A	151020330	3	1	65	1	0	0	0	0	1	0	0	0	2058	623	22	4	9	4	C1orf56	1	151020330	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	32489831	151020330	98230291	31	12862											
ZBTB7B	51043	broad.mit.edu	37	chr1	154987396	154987397	+	Frame_Shift_Del	DEL	GT	-	-																															cactgggggagcaggggccgGtgtgtgtgagctggactttg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:154987396_154987397delGT	uc001fgk.3	+	3	418_419	c.260_261delGT	c.(259-261)GGTfs	p.G87fs	ZBTB7B_uc009wpa.2_Frame_Shift_Del_p.G87fs|ZBTB7B_uc001fgj.3_Frame_Shift_Del_p.G121fs|ZBTB7B_uc010peq.1_Frame_Shift_Del_p.G121fs|ZBTB7B_uc001fgl.3_Frame_Shift_Del_p.G87fs	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	87	BTB.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCAGGGGCCGGTGTGTGTGAGC	0.629													---	---	---								-	154987397	-	-	154987396	7	5	65	1	0	1	0	1	0	0	0	0	17621	1261	44	0	262	0	ZBTB7B	1	154987396	Frame_Shift_Del	DEL	GT	TCGA-CN-5369-01A-01D-1434-08	3967066	154987396	94263225	32	12863											
C1orf104	284618	broad.mit.edu	37	chr1	155290588	155290588	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttaggatatatcaaaccctCtaggtgggtgacaaaagacg	14	9	10	8	1	2	2	1	1	1	1	2	3	2	3	1	3	1	0	1	3	7	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:155290588C>G	uc001fki.2	-	2	969	c.692G>C	c.(691-693)AGA>ACA	p.R231T	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_Intron|RUSC1_uc001fkj.2_5'Flank|RUSC1_uc001fkk.2_5'Flank|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank	NM_001039517	NP_001034606	Q66K80	RUAS1_HUMAN	hypothetical protein LOC284618	231											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.32e-10)|all cancers(21;3.51e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			ATCAAACCCTCTAGGTGGGTG	0.612													5	52					0	0	0	0	G	155290588	G	G	155290588	3	3	65	1	0	0	0	0	1	0	0	0	1987	913	32	2	22	2	C1orf104	1	155290588	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	303192	155290588	93960033	33	12864											
GON4L	54856	broad.mit.edu	37	chr1	155735586	155735586	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagcaatgtccacattcacGtgggccttatcttcaggggt	9	11	10	11	1	3	0	2	0	1	0	4	0	4	0	2	3	1	1	2	3	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:155735586G>A	uc001flz.2	-	21	3775	c.3678C>T	c.(3676-3678)CAC>CAT	p.H1226H	GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Silent_p.H1226H|GON4L_uc009wrh.1_Silent_p.H1226H|GON4L_uc001fma.1_Silent_p.H1226H|GON4L_uc001fmb.3_Silent_p.H422H|GON4L_uc001fmc.2_Silent_p.H1226H|GON4L_uc001fmd.3_Silent_p.H1226H|GON4L_uc009wri.2_Silent_p.H812H	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	1226					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CCACATTCACGTGGGCCTTAT	0.493													10	103					0	0	0	0	A	155735586	A	A	155735586	2	1	65	1	0	0	0	0	0	0	0	1	6609	1136	40	1		1	GON4L	1	155735586	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	444998	155735586	93515035	34	12865											
IQGAP3	128239	broad.mit.edu	37	chr1	156521543	156521543	+	Frame_Shift_Del	DEL	G	-	-																															caaggaggagatggtaccgaGgggcgacagggaggctgaca																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:156521543delG	uc001fpf.2	-	15	1763	c.1688delC	c.(1687-1689)CCTfs	p.P563fs	IQGAP3_uc009wsb.1_Frame_Shift_Del_p.P520fs	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	563					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATGGTACCGAGGGGCGACAGG	0.562													---	---	---								-	156521543	-	-	156521543	7	5	65	1	0	1	0	1	0	0	0	0	7855	1000	35	0	3303	0	IQGAP3	1	156521543	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	785957	156521543	92729078	35	12866											
BCAN	63827	broad.mit.edu	37	chr1	156617318	156617318	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggggtcgtctttctctaccGagagggctctgcccgctatg	5	11	13	12	3	3	1	0	0	3	1	5	2	3	1	2	3	2	2	2	3	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:156617318G>A	uc001fpp.2	+	4	821	c.485G>A	c.(484-486)CGA>CAA	p.R162Q	BCAN_uc001fpo.2_Missense_Mutation_p.R162Q	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	162	Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTTCTCTACCGAGAGGGCTCT	0.622													10	86					0	0	0	0	A	156617318	A	A	156617318	3	1	65	1	0	0	0	0	1	0	0	0	1347	1058	37	1	495	1	BCAN	1	156617318	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	95775	156617318	92633303	36	12867											
BCAN	63827	broad.mit.edu	37	chr1	156617836	156617836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatggcttccccggggtcCggaactatggtgtggtggac	5	10	17	9	2	0	0	0	0	0	0	2	3	2	3	3	8	1	1	3	8	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:156617836C>T	uc001fpp.2	+	5	1039	c.703C>T	c.(703-705)CGG>TGG	p.R235W	BCAN_uc001fpo.2_Missense_Mutation_p.R235W	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	235	Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCCCGGGGTCCGGAACTATGG	0.517													20	191					0	0	0	0	T	156617836	T	T	156617836	3	4	65	1	0	0	0	0	1	0	0	0	1347	643	23	1	717	1	BCAN	1	156617836	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	518	156617836	92632785	37	12868											
ARHGEF11	9826	broad.mit.edu	37	chr1	156914199	156914199	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcaggggtccctcatggatCatttttctggttgtaagatc	7	15	11	8	0	4	1	3	0	1	1	6	2	5	2	1	4	0	2	1	4	1	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:156914199C>T	uc001fqo.2	-	30	3938	c.2898G>A	c.(2896-2898)ATG>ATA	p.M966I	ARHGEF11_uc010phu.1_Missense_Mutation_p.M382I|ARHGEF11_uc001fqn.2_Missense_Mutation_p.M1006I	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	966	PH.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCTCATGGATCATTTTTCTGG	0.393													11	118					0	0	0	0	T	156914199	T	T	156914199	3	4	65	1	0	0	0	0	1	0	0	0	896	826	29	2	1714	2	ARHGEF11	1	156914199	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	296363	156914199	92336422	38	12869											
KCNJ10	3766	broad.mit.edu	37	chr1	160012273	160012273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcccattaggggccggCtttctgtctgagtggtctga	4	12	15	10	1	3	2	0	2	3	0	3	2	3	2	2	5	0	1	2	5	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:160012273C>T	uc001fuw.1	-	2	200	c.50G>A	c.(49-51)AGC>AAC	p.S17N		NM_002241	NP_002232	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily	17	Cytoplasmic (By similarity).					integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TAGGGGCCGGCTTTCTGTCTG	0.537													7	106					0	0	0	0	T	160012273	T	T	160012273	3	4	65	1	0	0	0	0	1	0	0	0	8083	797	28	4	1093	4	KCNJ10	1	160012273	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3098074	160012273	89238348	39	12870											
KCNJ9	3765	broad.mit.edu	37	chr1	160053931	160053931	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcaacgtgcagcagggcaaCgtgcgcgagacataccgcta	11	5	13	12	5	0	1	0	0	0	1	0	2	0	1	1	1	7	5	1	1	4	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:160053931C>T	uc001fuy.1	+	2	353	c.111C>T	c.(109-111)AAC>AAT	p.N37N		NM_004983	NP_004974	Q92806	IRK9_HUMAN	potassium inwardly-rectifying channel subfamily	37	Cytoplasmic (By similarity).				synaptic transmission	integral to membrane|plasma membrane	G-protein activated inward rectifier potassium channel activity|protein binding			ovary(1)|skin(1)	2	all_cancers(52;5.86e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGCAGGGCAACGTGCGCGAGA	0.572													3	8					0	0	0	0	T	160053931	T	T	160053931	2	4	65	1	0	0	0	0	0	0	0	1	8096	535	19	1		1	KCNJ9	1	160053931	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	41658	160053931	89196690	40	12871											
USF1	7391	broad.mit.edu	37	chr1	161012411	161012411	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gggaaggtggcagctgactgGatgctggcaatagccacact	10	7	15	9	0	0	1	0	1	0	0	0	3	0	3	1	5	3	4	1	5	3	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:161012411G>C	uc001fxi.2	-	4	303	c.108C>G	c.(106-108)ATC>ATG	p.I36M	USF1_uc001fxj.2_Translation_Start_Site	NM_007122	NP_009053	P22415	USF1_HUMAN	upstream stimulatory factor 1 isoform 1	36					cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CAGCTGACTGGATGCTGGCAA	0.537													4	49					0	0	0	0	C	161012411	C	C	161012411	3	2	65	1	0	0	0	0	1	0	0	0	17100	1164	41	2	856	2	USF1	1	161012411	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	958480	161012411	88238210	41	12872											
FCGR2B	2213	broad.mit.edu	37	chr1	161647336	161647336	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagcctgatgaccagaaccGtatttagtctccattgtctt	10	13	8	10	1	2	4	0	2	2	2	3	4	2	4	4	0	2	1	4	0	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:161647336G>A	uc001gaz.1	+	8	1018	c.926G>A	c.(925-927)CGT>CAT	p.R309H	FCGR2B_uc001gay.1_Missense_Mutation_p.R308H|FCGR2B_uc001gba.1_Missense_Mutation_p.R289H|FCGR2B_uc001gbb.1_Missense_Mutation_p.R290H|FCGR2B_uc009wun.1_Missense_Mutation_p.R302H	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	309	Cytoplasmic (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GACCAGAACCGTATTTAGTCT	0.478			T	?	ALL								9	199					0	0	0	0	A	161647336	A	A	161647336	3	1	65	1	0	0	0	0	1	0	0	0	5814	1145	40	1	956	1	FCGR2B	1	161647336	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	634925	161647336	87603285	42	12873											
OLFML2B	25903	broad.mit.edu	37	chr1	161993108	161993108	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtctcgtcctccgcaggcGccactgtctgcgcatctggg	4	9	13	15	4	3	0	0	0	3	0	6	1	5	0	3	2	1	2	3	2	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:161993108G>A	uc001gbu.2	-	1	537	c.113C>T	c.(112-114)GCG>GTG	p.A38V	OLFML2B_uc010pkq.1_Missense_Mutation_p.A38V	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	38										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			CTCCGCAGGCGCCACTGTCTG	0.597													9	81					0	0	0	0	A	161993108	A	A	161993108	3	1	65	1	0	0	0	0	1	0	0	0	10912	1087	38	1	2171	1	OLFML2B	1	161993108	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	345772	161993108	87257513	43	12874											
UCK2	7371	broad.mit.edu	37	chr1	165860506	165860506	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaaaacactcaaagaaatCactgaagggaaaacagtcca	20	5	6	10	0	3	2	3	1	0	1	4	3	4	3	1	1	2	0	1	1	7	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:165860506C>G	uc001gdp.2	+	3	484	c.303C>G	c.(301-303)ATC>ATG	p.I101M	UCK2_uc010plb.1_Nonsense_Mutation_p.S11*	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	101					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					TCAAAGAAATCACTGAAGGGA	0.413													6	62					0	0	0	0	G	165860506	G	G	165860506	3	3	65	1	0	0	0	0	1	0	0	0	16992	816	29	2	313	2	UCK2	1	165860506	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3867398	165860506	83390115	44	12875											
ADCY10	55811	broad.mit.edu	37	chr1	167817662	167817662	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttgtgaggtgacagacttCttcactttccttatcactat	9	16	6	10	0	3	3	2	2	1	1	4	3	4	3	1	1	0	0	1	1	2	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:167817662C>G	uc001ger.2	-	19	2672	c.2374G>C	c.(2374-2376)GAA>CAA	p.E792Q	ADCY10_uc009wvk.2_Missense_Mutation_p.E700Q|ADCY10_uc010plj.1_Missense_Mutation_p.E639Q|ADCY10_uc009wvl.2_Missense_Mutation_p.E791Q	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	792					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						TGACAGACTTCTTCACTTTCC	0.338													9	168					0	0	0	0	G	167817662	G	G	167817662	3	3	65	1	0	0	0	0	1	0	0	0	293	922	32	2	2518	2	ADCY10	1	167817662	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1957156	167817662	81432959	45	12876											
ATP1B1	481	broad.mit.edu	37	chr1	169096464	169096464	+	RNA	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgtttttatttttagatGtgcccagtgaaccgaaagaa	11	16	9	5	1	0	3	0	1	0	2	0	4	0	3	2	0	2	1	2	0	5	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:169096464G>A	uc001gfs.1	+	4		c.506G>A			uc010plp.1_5'Flank			P05026	AT1B1_HUMAN	Synthetic construct DNA, clone: pF1KB8186, Homo sapiens ATP1B1 gene for ATPase, Na+/K+ transporting, beta 1 polypeptide, without stop codon, in Flexi system.						ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	all_hematologic(923;0.208)					ATTTTTAGATGTGCCCAGTGA	0.393													8	86					0	0	0	0	A	169096464	A	A	169096464	1	1	65	0	1	0	0	0	0	0	0	0	1134	1377	48	4		4	ATP1B1	1	169096464	RNA	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1278802	169096464	80154157	46	12877											
DNM3	26052	broad.mit.edu	37	chr1	172011177	172011177	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaatttgctgtggactttGagaagagaattgaagggtca	13	11	13	4	0	1	3	1	2	0	2	1	6	1	4	0	2	2	2	0	2	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:172011177G>C	uc001gie.2	+	8	1197	c.1021G>C	c.(1021-1023)GAG>CAG	p.E341Q	DNM3_uc001gid.3_Missense_Mutation_p.E341Q|DNM3_uc009wwb.2_Missense_Mutation_p.E341Q|DNM3_uc001gif.2_Missense_Mutation_p.E341Q	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	341					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						TGTGGACTTTGAGAAGAGAAT	0.378													14	147					0	0	0	0	C	172011177	C	C	172011177	3	2	65	1	0	0	0	0	1	0	0	0	4695	1291	45	2	1051	2	DNM3	1	172011177	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2914713	172011177	77239444	47	12878											
RASAL2	9462	broad.mit.edu	37	chr1	178414790	178414790	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacaacagtatcttcatgaCgcactgggtatgaaagagaa	15	8	11	7	1	2	3	1	2	1	1	2	5	2	4	0	2	1	3	0	2	5	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:178414790C>T	uc001glr.2	+	7	1301	c.1176C>T	c.(1174-1176)GAC>GAT	p.D392D	RASAL2_uc001glq.2_Silent_p.D540D	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	392	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						ATCTTCATGACGCACTGGGTA	0.388													10	120					0	0	0	0	T	178414790	T	T	178414790	2	4	65	1	0	0	0	0	0	0	0	1	13129	535	19	1		1	RASAL2	1	178414790	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6403613	178414790	70835831	48	12879											
KIAA1614	57710	broad.mit.edu	37	chr1	180885980	180885980	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctacccttttccagatggCgtggtgacagaggcagatct	8	11	11	11	1	1	4	0	1	1	3	3	4	3	4	3	3	1	1	3	3	1	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:180885980C>T	uc001gok.2	+	2	808	c.741C>T	c.(739-741)GGC>GGT	p.G247G		NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	247										ovary(3)|skin(1)	4						TTCCAGATGGCGTGGTGACAG	0.587													26	323					0	0	0	0	T	180885980	T	T	180885980	2	4	65	1	0	0	0	0	0	0	0	1	8287	755	27	1		1	KIAA1614	1	180885980	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2471190	180885980	68364641	49	12880											
CACNA1E	777	broad.mit.edu	37	chr1	181689432	181689432	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttcctcctcttcctcttcatCgttgtctttgctctcctagg	2	19	5	15	1	5	0	1	0	4	0	10	0	8	0	4	1	1	2	4	1	1	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:181689432C>G	uc001gow.2	+	14	2007	c.1842C>G	c.(1840-1842)ATC>ATG	p.I614M	CACNA1E_uc009wxs.2_Missense_Mutation_p.I521M	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	614	Helical; Name=S5 of repeat II.|II.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCCTCTTCATCGTTGTCTTTG	0.468													4	42					0	0	0	0	G	181689432	G	G	181689432	3	3	65	1	0	0	0	0	1	0	0	0	2554	874	31	3	1896	3	CACNA1E	1	181689432	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	803452	181689432	67561189	50	12881											
C1orf14	81626	broad.mit.edu	37	chr1	182873548	182873548	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttcagaagtaatcataatttCctctctctttccaactcctg	10	16	3	12	0	4	1	2	0	2	1	8	1	7	1	3	0	1	1	3	0	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:182873548C>G	uc001gpu.2	-	8	1639	c.1354G>C	c.(1354-1356)GAA>CAA	p.E452Q	C1orf14_uc001gpv.2_Missense_Mutation_p.E333Q|C1orf14_uc010pnz.1_Missense_Mutation_p.E310Q|C1orf14_uc001gpw.2_Missense_Mutation_p.E172Q	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	524											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		ATCATAATTTCCTCTCTCTTT	0.363													8	131					0	0	0	0	G	182873548	G	G	182873548	3	3	65	1	0	0	0	0	1	0	0	0	2009	864	30	2	619	2	C1orf14	1	182873548	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1184116	182873548	66377073	51	12882											
NMNAT2	23057	broad.mit.edu	37	chr1	183255842	183255842	+	Frame_Shift_Del	DEL	G	-	-																															gctgttctggtaaatgggctGgggggtctcgttttgtggct																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:183255842delG	uc001gqc.1	-	5	738	c.403delC	c.(403-405)CAGfs	p.Q135fs	NMNAT2_uc001gqb.1_Frame_Shift_Del_p.Q130fs|NMNAT2_uc001gqd.2_Frame_Shift_Del_p.Q30fs	NM_015039	NP_055854	Q9BZQ4	NMNA2_HUMAN	nicotinamide mononucleotide adenylyltransferase	135					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			skin(1)	1						TAAATGGGCTGGGGGGTCTCG	0.453													---	---	---								-	183255842	-	-	183255842	7	5	65	1	0	1	0	1	0	0	0	0	10553	1357	47	0	548	0	NMNAT2	1	183255842	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	382294	183255842	65994779	52	12883											
NCF2	4688	broad.mit.edu	37	chr1	183543721	183543723	+	In_Frame_Del	DEL	CTT	-	-																															tcagcttttttccattcctcCttcttggcatacatgaaagc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:183543721_183543723delCTT	uc001gqj.3	-	4	675_677	c.400_402delAAG	c.(400-402)AAGdel	p.K134del	NCF2_uc010pod.1_Intron|NCF2_uc010poe.1_Intron|NCF2_uc001gqk.3_In_Frame_Del_p.K134del	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	134	TPR 3.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						TCCATTCCTCCTTCTTGGCATAC	0.448													---	---	---								-	183543723	-	-	183543721	7	5	65	1	0	1	0	1	0	0	0	0	10271	680	24	0	1226	0	NCF2	1	183543721	In_Frame_Del	DEL	CTT	TCGA-CN-5369-01A-01D-1434-08	287879	183543721	65706900	53	12884											
ASPM	259266	broad.mit.edu	37	chr1	197111586	197111586	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaaaatggattcttttgAtttctcgcacttctgtatgt	10	17	8	6	1	3	2	0	1	3	1	4	4	3	3	0	1	0	2	0	1	3	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:197111586A>G	uc001gtu.2	-	3	2053	c.1796T>C	c.(1795-1797)ATC>ACC	p.I599T	ASPM_uc001gtv.2_Missense_Mutation_p.I599T|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	599					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GATTCTTTTGATTTCTCGCAC	0.398													17	358					0	0	0	0	G	197111586	G	G	197111586	3	3	65	1	0	0	0	0	1	0	0	0	1058	333	12	5	8741	5	ASPM	1	197111586	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	13567865	197111586	52139035	54	12885											
CRB1	23418	broad.mit.edu	37	chr1	197390409	197390409	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtccctgtgtgaaatcgcaaCcacactttcatttgagggcg	9	11	10	11	2	1	2	1	2	0	0	3	2	2	2	2	1	1	1	2	1	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:197390409C>T	uc001gtz.2	+	6	1586	c.1451C>T	c.(1450-1452)ACC>ATC	p.T484I	CRB1_uc010poz.1_Missense_Mutation_p.T415I|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.T372I|CRB1_uc010ppb.1_Missense_Mutation_p.T484I|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_Missense_Mutation_p.T133I	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	484	Extracellular (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GAAATCGCAACCACACTTTCA	0.498													10	92					0	0	0	0	T	197390409	T	T	197390409	3	4	65	1	0	0	0	0	1	0	0	0	3863	507	18	4	1473	4	CRB1	1	197390409	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	278823	197390409	51860212	55	12886											
TNNT2	7139	broad.mit.edu	37	chr1	201333480	201333480	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccggatgcgctgctgctcGgcccgctctgcccgacgtct	2	10	12	17	6	2	0	0	0	2	0	4	2	3	1	3	2	4	4	3	2	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:201333480G>T	uc001gwf.2	-	11	504	c.435C>A	c.(433-435)GCC>GCA	p.A145A	TNNT2_uc009wzn.2_5'Flank|TNNT2_uc009wzo.2_5'Flank|TNNT2_uc009wzp.2_5'Flank|TNNT2_uc001gwg.2_Silent_p.A135A|TNNT2_uc001gwh.2_Silent_p.A130A|TNNT2_uc001gwi.2_Silent_p.A105A|TNNT2_uc009wzr.2_Silent_p.A76A|TNNT2_uc001gwj.1_5'Flank|TNNT2_uc009wzs.1_Silent_p.A110A|TNNT2_uc001gwk.1_Silent_p.A76A|TNNT2_uc009wzt.1_Silent_p.A135A	NM_000364	NP_000355	P45379	TNNT2_HUMAN	troponin T type 2, cardiac isoform 1	145					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding				0						GCTGCTGCTCGGCCCGCTCTG	0.642													5	49					1.23904e-05	1.28191e-05	1	0	T	201333480	T	T	201333480	2	4	65	1	0	0	0	0	0	0	0	1	16397	1103	39	3		3	TNNT2	1	201333480	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3943071	201333480	47917141	56	12887											
PPFIA4	8497	broad.mit.edu	37	chr1	203025986	203025986	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgcacaagggcgccaagcGcaagggcatcaagtcgtcca	11	4	12	14	3	1	0	1	0	0	0	3	0	2	0	3	2	2	3	3	2	4	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:203025986G>A	uc001gyz.2	+	6	1390	c.797G>A	c.(796-798)CGC>CAC	p.R266H	PPFIA4_uc009xaj.2_Missense_Mutation_p.R897H|PPFIA4_uc010pqf.1_Missense_Mutation_p.R479H|PPFIA4_uc001gza.2_Missense_Mutation_p.R266H|PPFIA4_uc001gzb.1_5'UTR	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	266					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GGCGCCAAGCGCAAGGGCATC	0.592													7	55					0	0	0	0	A	203025986	A	A	203025986	3	1	65	1	0	0	0	0	1	0	0	0	12367	1087	38	1	819	1	PPFIA4	1	203025986	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1692506	203025986	46224635	57	12888											
USH2A	7399	broad.mit.edu	37	chr1	215960129	215960129	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcttatcacagtgcaaaTgtggctggtaaagttgaagt	11	12	10	8	0	2	1	1	1	1	0	2	1	2	1	1	2	1	4	1	2	5	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:215960129T>C	uc001hku.1	-	52	10657	c.10270A>G	c.(10270-10272)ATT>GTT	p.I3424V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3424	Fibronectin type-III 19.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAGTGCAAATGTGGCTGGTA	0.463										HNSCC(13;0.011)			5	43					0	0	0	0	C	215960129	C	C	215960129	3	2	65	1	0	0	0	0	1	0	0	0	17104	1464	51	5	5422	5	USH2A	1	215960129	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	12934143	215960129	33290492	58	12889											
ITPKB	3707	broad.mit.edu	37	chr1	226829801	226829801	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgggcttcttccgggcctTcgtgagctcctcctccaggt	2	12	12	15	2	1	1	0	1	1	0	6	1	5	1	5	3	1	3	5	3	0	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:226829801T>C	uc010pvo.1	-	5	2612	c.2272A>G	c.(2272-2274)AAG>GAG	p.K758E		NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	758							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				TTCCGGGCCTTCGTGAGCTCC	0.647													20	238					0	0	0	0	C	226829801	C	C	226829801	3	2	65	1	0	0	0	0	1	0	0	0	7957	1792	62	5	584	5	ITPKB	1	226829801	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	10869672	226829801	22420820	59	12890											
ITPKB	3707	broad.mit.edu	37	chr1	226924442	226924442	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgatcctgtaggggcagcccGgccgggaagaggtggcattc	7	7	17	10	2	0	2	0	1	0	1	2	3	1	3	3	6	1	3	3	6	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:226924442G>A	uc010pvo.1	-	2	1058	c.718C>T	c.(718-720)CGG>TGG	p.R240W	ITPKB_uc001hqh.2_Missense_Mutation_p.R240W	NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	240							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				GGGGCAGCCCGGCCGGGAAGA	0.602													20	223					0	0	0	0	A	226924442	A	A	226924442	3	1	65	1	0	0	0	0	1	0	0	0	7957	1115	39	1	2150	1	ITPKB	1	226924442	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	94641	226924442	22326179	60	12891											
LYST	1130	broad.mit.edu	37	chr1	235969573	235969573	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgcttggtgcatatgttCaggagaaggcaagacaaggc	11	9	14	7	0	1	2	1	0	0	2	1	3	1	2	0	4	3	5	0	4	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:235969573C>T	uc001hxj.2	-	6	3038	c.2863G>A	c.(2863-2865)GAA>AAA	p.E955K	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.E955K	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	955					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGCATATGTTCAGGAGAAGGC	0.458									Chediak-Higashi_syndrome				9	130					0	0	0	0	T	235969573	T	T	235969573	3	4	65	1	0	0	0	0	1	0	0	0	9179	835	29	2	8734	2	LYST	1	235969573	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	9045131	235969573	13281048	61	12892											
ZNF124	7678	broad.mit.edu	37	chr1	247319909	247319909	+	Frame_Shift_Del	DEL	T	-	-																															gggcttttctccagtatgagTttttttatgcttccaaaggg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr1:247319909delT	uc001ick.2	-	4	1154	c.1015delA	c.(1015-1017)ACTfs	p.T339fs	ZNF124_uc001ici.2_Intron|ZNF124_uc001icj.1_Frame_Shift_Del_p.T277fs	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	339	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			CCAGTATGAGTTTTTTTATGC	0.368													---	---	---								-	247319909	-	-	247319909	7	5	65	1	0	1	0	1	0	0	0	0	17787	1725	60	0	44	0	ZNF124	1	247319909	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	11350336	247319909	1930712	62	12893											
ADI1	55256	broad.mit.edu	37	chr2	3504681	3504681	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atccactggtcctccttgtcCctcacatcgaagtacccact	8	11	5	17	1	1	0	1	0	0	0	6	1	5	0	5	1	1	1	5	1	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:3504681C>T	uc002qxp.3	-	3	416	c.324G>A	c.(322-324)AGG>AGA	p.R108R	ADI1_uc010yiq.1_RNA	NM_018269	NP_060739	Q9BV57	MTND_HUMAN	acireductone dioxygenase 1	108				R -> G (in Ref. 5; BAD96187).	L-methionine salvage from methylthioadenosine	cytoplasm|nucleus|plasma membrane	acireductone dioxygenase (Ni2+-requiring) activity|metal ion binding|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0729)|Epithelial(75;0.173)|all cancers(51;0.228)		CCTCCTTGTCCCTCACATCGA	0.542													8	68					0	0	0	0	T	3504681	T	T	3504681	2	4	65	1	0	0	0	0	0	0	0	1	315	622	22	4		4	ADI1	2	3504681	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08		3504681	239694692	63	12894											
COLEC11	78989	broad.mit.edu	37	chr2	3691322	3691322	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccttaccccacagctgtcGccggtgtgcgcgagacggag	6	7	14	14	5	0	1	0	0	0	1	1	3	0	2	4	2	4	1	4	2	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:3691322G>A	uc002qya.2	+	7	578	c.430G>A	c.(430-432)GCC>ACC	p.A144T	COLEC11_uc002qxz.2_Missense_Mutation_p.A141T|COLEC11_uc002qyb.2_Missense_Mutation_p.A120T|COLEC11_uc002qyc.2_Missense_Mutation_p.A120T|COLEC11_uc010ewo.2_Missense_Mutation_p.A96T|COLEC11_uc010ewp.2_Missense_Mutation_p.A118T|COLEC11_uc010ewq.2_Missense_Mutation_p.A94T|COLEC11_uc010ewr.2_Missense_Mutation_p.A94T|COLEC11_uc010ews.2_Missense_Mutation_p.A70T	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	144	Potential.					collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		CACAGCTGTCGCCGGTGTGCG	0.637													15	127					0	0	0	0	A	3691322	A	A	3691322	3	1	65	1	0	0	0	0	1	0	0	0	3726	1087	38	1	535	1	COLEC11	2	3691322	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	186641	3691322	239508051	64	12895											
WDR35	57539	broad.mit.edu	37	chr2	20138032	20138032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttttttaaataccaaagtCgggggtgtggattgtcctct	8	16	10	7	1	1	0	0	0	1	0	3	1	2	1	2	3	1	0	2	3	4	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:20138032C>T	uc002rdi.2	-	19	2198	c.2090G>A	c.(2089-2091)CGA>CAA	p.R697Q	WDR35_uc002rdj.2_Missense_Mutation_p.R686Q|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Missense_Mutation_p.R262Q|WDR35_uc002rdk.3_Missense_Mutation_p.R262Q	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	697										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATACCAAAGTCGGGGGTGTGG	0.443													14	166					0	0	0	0	T	20138032	T	T	20138032	3	4	65	1	0	0	0	0	1	0	0	0	17357	884	31	1	1495	1	WDR35	2	20138032	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	16446710	20138032	223061341	65	12896											
ITSN2	50618	broad.mit.edu	37	chr2	24443816	24443816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagcagcagcctcctcacctCgacgacgagctgaaggtcag	10	5	11	15	3	2	1	2	1	0	0	4	4	3	1	3	1	4	3	3	1	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:24443816C>T	uc002rfe.2	-	30	3955	c.3697G>A	c.(3697-3699)GAG>AAG	p.E1233K	ITSN2_uc002rff.2_Missense_Mutation_p.E1206K|ITSN2_uc002rfg.2_Missense_Mutation_p.E1233K	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1233	DH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCCTCACCTCGACGACGAGC	0.552													32	223					0	0	0	0	T	24443816	T	T	24443816	3	4	65	1	0	0	0	0	1	0	0	0	7966	893	31	1	1491	1	ITSN2	2	24443816	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4305784	24443816	218755557	66	12897											
NCOA1	8648	broad.mit.edu	37	chr2	24952396	24952396	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggattagatgtattatcagaGagatttccaccacaacaagc	15	10	8	8	0	1	3	1	0	0	3	2	5	2	4	2	1	2	1	2	1	5	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:24952396G>C	uc002rfk.2	+	15	3171	c.2913G>C	c.(2911-2913)GAG>GAC	p.E971D	NCOA1_uc010eye.2_Missense_Mutation_p.E971D|NCOA1_uc002rfi.2_Missense_Mutation_p.E820D|NCOA1_uc002rfj.2_Missense_Mutation_p.E971D|NCOA1_uc002rfl.2_Missense_Mutation_p.E971D	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	971	Interaction with CREBBP.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATTATCAGAGAGATTTCCAC	0.403			T	PAX3	alveolar rhadomyosarcoma								23	188					0	0	0	0	C	24952396	C	C	24952396	3	2	65	1	0	0	0	0	1	0	0	0	10282	933	33	2	2963	2	NCOA1	2	24952396	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	508580	24952396	218246977	67	12898											
IFT172	26160	broad.mit.edu	37	chr2	27684340	27684340	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcttgctgtgtgtccatcagCcactggtagtaactacgacg	8	12	10	11	2	2	0	1	0	1	0	3	1	3	0	2	1	4	3	2	1	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:27684340C>T	uc002rku.2	-	22	2289	c.2238G>A	c.(2236-2238)TGG>TGA	p.W746*		NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	746					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TGTCCATCAGCCACTGGTAGT	0.582													12	195					0	0	0	0	T	27684340	T	T	27684340	4	4	65	1	0	0	0	0	0	1	0	0	7596	740	26	4	3119	4	IFT172	2	27684340	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2731944	27684340	215515033	68	12899											
FAM82A1	151393	broad.mit.edu	37	chr2	38202364	38202364	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcttttcagtttagagatGaaatagagtttatgtggcga	11	17	10	3	1	2	3	1	1	1	2	2	5	2	3	0	1	0	2	0	1	4	8			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:38202364G>A	uc002rql.2	+	4	760	c.637G>A	c.(637-639)GAA>AAA	p.E213K	FAM82A1_uc002rqn.1_Missense_Mutation_p.E391K|FAM82A1_uc002rqk.1_Missense_Mutation_p.E68K|FAM82A1_uc002rqm.2_Missense_Mutation_p.E68K	NM_144713	NP_653314	Q96LZ7	RMD2_HUMAN	family with sequence similarity 82, member A1	213						cytoplasm|integral to membrane|microtubule|spindle pole	binding			ovary(1)	1						GTTTAGAGATGAAATAGAGTT	0.318													7	88					0	0	0	0	A	38202364	A	A	38202364	3	1	65	1	0	0	0	0	1	0	0	0	5662	1291	45	2	1641	2	FAM82A1	2	38202364	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	10518024	38202364	204997009	69	12900											
TMEM178	130733	broad.mit.edu	37	chr2	39934249	39934249	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccgtccttctctgcggctGcattgtggccacagtcagtt	5	12	11	13	2	2	0	1	0	1	0	4	0	3	0	3	2	3	3	3	2	0	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:39934249G>A	uc002rrt.2	+	3	600	c.575G>A	c.(574-576)TGC>TAC	p.C192Y	TMEM178_uc010fam.1_Intron	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	192	Helical; (Potential).					integral to membrane					0		all_hematologic(82;0.248)				CTCTGCGGCTGCATTGTGGCC	0.527													5	49					0	0	0	0	A	39934249	A	A	39934249	3	1	65	1	0	0	0	0	1	0	0	0	16161	1319	46	4	585	4	TMEM178	2	39934249	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1731885	39934249	203265124	70	12901											
NRXN1	9378	broad.mit.edu	37	chr2	50149190	50149190	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggactgtgctgagttactGatgtagtttcgactctcgtc	6	16	11	8	2	1	2	0	2	1	0	4	4	1	3	0	1	2	4	0	1	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:50149190G>A	uc010fbp.2	-	6	2028	c.1221C>T	c.(1219-1221)ATC>ATT	p.I407I	NRXN1_uc002rxb.3_Silent_p.I1141I|NRXN1_uc010fbq.2_Silent_p.I1512I|NRXN1_uc002rxe.3_Silent_p.I1442I|NRXN1_uc010yon.1_Silent_p.I107I|NRXN1_uc002rxa.3_Silent_p.I104I	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	407	Cytoplasmic (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CTGAGTTACTGATGTAGTTTC	0.463													13	137					0	0	0	0	A	50149190	A	A	50149190	2	1	65	1	0	0	0	0	0	0	0	1	10719	1280	45	2		2	NRXN1	2	50149190	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	10214941	50149190	193050183	71	12902											
NRXN1	9378	broad.mit.edu	37	chr2	50280582	50280582	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcacatttcccactatggCgatgttggcatcgttttcgg	6	15	9	11	3	1	0	1	0	1	0	5	1	2	0	1	3	0	3	1	3	1	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:50280582C>T	uc010fbp.2	-	4	1567	c.760G>A	c.(760-762)GCC>ACC	p.A254T	NRXN1_uc002rxb.3_Missense_Mutation_p.A991T|NRXN1_uc010fbq.2_Missense_Mutation_p.A1359T|NRXN1_uc002rxe.3_Missense_Mutation_p.A1289T	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	254	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCCACTATGGCGATGTTGGCA	0.507													13	142					0	0	0	0	T	50280582	T	T	50280582	3	4	65	1	0	0	0	0	1	0	0	0	10719	768	27	1	580	1	NRXN1	2	50280582	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	131392	50280582	192918791	72	12903											
CHAC2	494143	broad.mit.edu	37	chr2	53995077	53995077	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggtggatttcccctatcaGgacaagctggtcggatacat	11	10	11	9	1	1	0	1	0	0	0	3	3	2	3	2	5	2	1	2	5	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:53995077G>C	uc002rxk.1	+	1	149	c.54G>C	c.(52-54)CAG>CAC	p.Q18H	ASB3_uc002rxg.1_Intron|ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Intron|ASB3_uc010yoo.1_Intron	NM_001008708	NP_001008708	Q8WUX2	CHAC2_HUMAN	ChaC, cation transport regulator-like 2	18											0			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCCCCTATCAGGACAAGCTGG	0.627											OREG0014616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	40					0	0	0	0	C	53995077	C	C	53995077	3	2	65	1	0	0	0	0	1	0	0	0	3324	991	35	4	56	4	CHAC2	2	53995077	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3714495	53995077	189204296	73	12904											
SPTBN1	6711	broad.mit.edu	37	chr2	54856884	54856884	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atcgacgagaaggagcagtgGctcaacaacatgcagatccc	14	5	11	11	2	1	2	1	0	0	2	3	5	2	3	1	2	4	3	1	2	3	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:54856884G>A	uc002rxu.2	+	14	2862	c.2613G>A	c.(2611-2613)TGG>TGA	p.W871*	SPTBN1_uc002rxv.1_Nonsense_Mutation_p.W871*|SPTBN1_uc002rxx.2_Nonsense_Mutation_p.W858*	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	871	Spectrin 6.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGGAGCAGTGGCTCAACAACA	0.602													6	78					0	0	0	0	A	54856884	A	A	54856884	4	1	65	1	0	0	0	0	0	1	0	0	15185	1212	42	4	2776	4	SPTBN1	2	54856884	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	861807	54856884	188342489	74	12905											
PNPT1	87178	broad.mit.edu	37	chr2	55894167	55894167	+	Frame_Shift_Del	DEL	T	-	-																															taatgctgatccatgaagggTtttaaacatatctacctcac																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:55894167delT	uc002rzf.2	-	13	1188	c.1135delA	c.(1135-1137)ACCfs	p.T379fs	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	379					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CCATGAAGGGTTTTAAACATA	0.313													---	---	---								-	55894167	-	-	55894167	7	5	65	1	0	1	0	1	0	0	0	0	12228	1725	60	0	1280	0	PNPT1	2	55894167	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	1037283	55894167	187305206	75	12906											
VAX2	25806	broad.mit.edu	37	chr2	71148327	71148327	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgccgagcagctgtaccGcctggagatggagttccagc	8	7	13	13	2	0	1	0	0	0	1	1	4	1	2	4	2	5	4	4	2	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:71148327G>A	uc002shh.2	+	2	379	c.347G>A	c.(346-348)CGC>CAC	p.R116H		NM_012476	NP_036608	Q9UIW0	VAX2_HUMAN	ventral anterior homeobox 2	116	Homeobox.				ectoderm development|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CAGCTGTACCGCCTGGAGATG	0.622													9	68					0	0	0	0	A	71148327	A	A	71148327	3	1	65	1	0	0	0	0	1	0	0	0	17203	1087	38	1	353	1	VAX2	2	71148327	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	15254160	71148327	172051046	76	12907											
RTKN	6242	broad.mit.edu	37	chr2	74653396	74653396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtgactggagccaagtgcGaggttggcctttgctgcaga	7	10	16	8	1	0	2	0	1	0	1	0	4	0	3	2	4	4	3	2	4	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:74653396G>A	uc002sle.2	-	12	1783	c.1666C>T	c.(1666-1668)CGC>TGC	p.R556C	RTKN_uc002slc.2_Missense_Mutation_p.R543C|RTKN_uc002sld.2_Missense_Mutation_p.R506C	NM_001015055	NP_001015055	Q9BST9	RTKN_HUMAN	rhotekin isoform a	556					apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1						AGCCAAGTGCGAGGTTGGCCT	0.622													34	320					0	0	0	0	A	74653396	A	A	74653396	3	1	65	1	0	0	0	0	1	0	0	0	13787	1058	37	1	29	1	RTKN	2	74653396	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3505069	74653396	168545977	77	12908											
LBX2	85474	broad.mit.edu	37	chr2	74725408	74725408	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacttgcgccgtttgcggccGaagggaccagggcccagcgc	6	5	16	14	5	0	0	0	0	0	0	0	3	0	1	4	3	3	1	4	3	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:74725408G>A	uc002slv.3	-	2	248	c.243C>T	c.(241-243)TTC>TTT	p.F81F	LBX2_uc002slw.2_Silent_p.F77F	NM_001009812	NP_001009812	Q6XYB7	LBX2_HUMAN	ladybird homeobox 2	81						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTTTGCGGCCGAAGGGACCAG	0.667													6	14					0	0	0	0	A	74725408	A	A	74725408	2	1	65	1	0	0	0	0	0	0	0	1	8694	1049	37	1		1	LBX2	2	74725408	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	72012	74725408	168473965	78	12909											
AUP1	550	broad.mit.edu	37	chr2	74756406	74756406	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacacatggtccgcactacGaatctggggacacaggaggt	11	6	13	11	2	1	0	0	0	1	0	2	3	2	2	1	5	1	2	1	5	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:74756406G>A	uc010yry.1	-	3	410	c.192C>T	c.(190-192)TTC>TTT	p.F64F	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_Silent_p.F64F|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_5'UTR|AUP1_uc010yrx.1_Silent_p.F121F|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ58836, highly similar to Ancient ubiquitous protein 1;	64	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						TCCGCACTACGAATCTGGGGA	0.637													5	58					0	0	0	0	A	74756406	A	A	74756406	2	1	65	1	0	0	0	0	0	0	0	1	1222	1049	37	1		1	AUP1	2	74756406	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	30998	74756406	168442967	79	12910											
HTRA2	27429	broad.mit.edu	37	chr2	74758074	74758074	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctctgggacgctcagctGatgtccggcaaggggagttt	6	10	15	10	2	2	1	1	1	1	0	3	3	3	3	2	4	2	4	2	4	1	1	rs142306682		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:74758074G>A	uc002smi.1	+	3	1350	c.748G>A	c.(748-750)GAT>AAT	p.D250N	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Intron|HTRA2_uc002smk.1_Missense_Mutation_p.D250N|HTRA2_uc002sml.1_Missense_Mutation_p.D250N|HTRA2_uc002smm.1_5'UTR|HTRA2_uc002smn.1_5'UTR|HTRA2_uc010ffl.2_5'UTR	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	250	Serine protease.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						ACGCTCAGCTGATGTCCGGCA	0.552													35	486					0	0	0	0	A	74758074	A	A	74758074	3	1	65	1	0	0	0	0	1	0	0	0	7493	1290	45	2	758	2	HTRA2	2	74758074	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1668	74758074	168441299	80	12911											
CTNNA2	1496	broad.mit.edu	37	chr2	80136879	80136879	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtggcggagtgcaacgccGtgcggcaggcgctccaggac	6	5	17	13	6	0	0	0	0	0	0	2	2	1	2	2	5	3	3	2	5	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:80136879G>A	uc010ysh.1	+	6	1017	c.1012G>A	c.(1012-1014)GTG>ATG	p.V338M	CTNNA2_uc010yse.1_Missense_Mutation_p.V338M|CTNNA2_uc010ysf.1_Missense_Mutation_p.V338M|CTNNA2_uc010ysg.1_Missense_Mutation_p.V338M	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	338					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GTGCAACGCCGTGCGGCAGGC	0.597													11	92					0	0	0	0	A	80136879	A	A	80136879	3	1	65	1	0	0	0	0	1	0	0	0	4030	1145	40	1		1	CTNNA2	2	80136879	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	5378805	80136879	163062494	81	12912											
TGFBRAP1	9392	broad.mit.edu	37	chr2	105889405	105889405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcacccttgccactggCggaggccctctgcagcagca	6	7	11	17	1	2	0	0	0	2	0	2	1	2	1	3	3	5	4	3	3	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:105889405C>T	uc002tcq.2	-	10	1963	c.1879G>A	c.(1879-1881)GCC>ACC	p.A627T	TGFBRAP1_uc010fjc.2_Missense_Mutation_p.A396T|TGFBRAP1_uc002tcr.3_Missense_Mutation_p.A627T	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	627					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						TTGCCACTGGCGGAGGCCCTC	0.577													12	71					0	0	0	0	T	105889405	T	T	105889405	3	4	65	1	0	0	0	0	1	0	0	0	15890	768	27	1	715	1	TGFBRAP1	2	105889405	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	25752526	105889405	137309968	82	12913											
GCC2	9648	broad.mit.edu	37	chr2	109111839	109111839	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcacactgtaacccgggaaGagggagaaggcatggagaca	14	4	15	8	1	0	3	0	0	0	3	0	6	0	4	1	4	2	3	1	4	3	1	rs148279219		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:109111839G>C	uc002tec.2	+	20	4694	c.4540G>C	c.(4540-4542)GAG>CAG	p.E1514Q	GCC2_uc002ted.2_Missense_Mutation_p.E1413Q	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1514	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AACCCGGGAAGAGGGAGAAGG	0.483													8	77					0	0	0	0	C	109111839	C	C	109111839	3	2	65	1	0	0	0	0	1	0	0	0	6321	943	33	2	4618	2	GCC2	2	109111839	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3222434	109111839	134087534	83	12914											
RANBP2	5903	broad.mit.edu	37	chr2	109383191	109383191	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttaaaaattctcaaaaacGaggtcaatggcaaactaaga	20	8	6	7	1	2	1	2	0	1	1	3	2	2	1	0	2	2	1	0	2	8	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:109383191G>A	uc002tem.3	+	20	6322	c.6196G>A	c.(6196-6198)GAG>AAG	p.E2066K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2066	RanBD1 2.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TCTCAAAAACGAGGTCAATGG	0.398													69	634					0	0	0	0	A	109383191	A	A	109383191	3	1	65	1	0	0	0	0	1	0	0	0	13093	1059	37	1	6274	1	RANBP2	2	109383191	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	271352	109383191	133816182	84	12915											
MKI67IP	84365	broad.mit.edu	37	chr2	122485323	122485323	+	Frame_Shift_Del	DEL	T	-	-																															ctgattgctgcttcttcgtcTttttttccgtgaatgtgtag																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:122485323delT	uc002tnk.2	-	7	936	c.859delA	c.(859-861)AGAfs	p.R287fs	uc002tnj.1_Intron	NM_032390	NP_115766	Q9BYG3	MK67I_HUMAN	MKI67 interacting nucleolar phosphoprotein	287					protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						CTTCTTCGTCTTTTTTTCCGT	0.294													---	---	---								-	122485323	-	-	122485323	7	5	65	1	0	1	0	1	0	0	0	0	9652	1617	56	0	26	0	MKI67IP	2	122485323	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	13102132	122485323	120714050	85	12916											
UGGT1	56886	broad.mit.edu	37	chr2	128935448	128935448	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaacgaagacttgctgagtGatggaacgagtgagaatgaa	15	8	14	4	2	0	6	0	5	0	2	0	10	0	7	0	1	3	1	0	1	5	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:128935448G>C	uc002tps.2	+	33	3845	c.3667G>C	c.(3667-3669)GAT>CAT	p.D1223H	UGGT1_uc002tpr.2_Missense_Mutation_p.D1199H	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1223					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						CTTGCTGAGTGATGGAACGAG	0.388													16	173					0	0	0	0	C	128935448	C	C	128935448	3	2	65	1	0	0	0	0	1	0	0	0	17009	1290	45	2	3797	2	UGGT1	2	128935448	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6450125	128935448	114263925	86	12917											
ARHGEF4	50649	broad.mit.edu	37	chr2	131803638	131803638	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggccctgctacctgacgcGccagaagcacccagccctgc	7	4	10	20	3	0	2	0	1	0	1	0	2	0	2	6	1	5	2	6	1	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:131803638G>A	uc002tsa.1	+	14	2469	c.1949G>A	c.(1948-1950)CGC>CAC	p.R650H	ARHGEF4_uc010fmw.1_Missense_Mutation_p.R798H|ARHGEF4_uc002tsb.1_3'UTR|ARHGEF4_uc010fmx.1_Missense_Mutation_p.R590H|ARHGEF4_uc002tsc.1_Missense_Mutation_p.R193H	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	650					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		TACCTGACGCGCCAGAAGCAC	0.667													17	186					0	0	0	0	A	131803638	A	A	131803638	3	1	65	1	0	0	0	0	1	0	0	0	908	1087	38	1	2087	1	ARHGEF4	2	131803638	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2868190	131803638	111395735	87	12918											
YSK4	80122	broad.mit.edu	37	chr2	135745629	135745629	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgagagtcggatccatcaaCgacttaactagggctcccgg	10	8	11	12	3	1	1	1	1	0	1	4	4	3	2	2	3	2	1	2	3	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:135745629C>T	uc002tue.1	-	7	844	c.813G>A	c.(811-813)TCG>TCA	p.S271S	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Silent_p.S158S|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_5'UTR|YSK4_uc002tui.3_Silent_p.S288S	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	271							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GATCCATCAACGACTTAACTA	0.483													23	151					0	0	0	0	T	135745629	T	T	135745629	2	4	65	1	0	0	0	0	0	0	0	1	17563	523	19	1		1	YSK4	2	135745629	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3941991	135745629	107453744	88	12919											
LRP1B	53353	broad.mit.edu	37	chr2	141625775	141625775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttttctcccagcaccactCatagaggcagattcaatgcg	10	11	8	12	1	3	2	2	0	1	2	4	2	3	2	2	1	2	3	2	1	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:141625775C>T	uc002tvj.1	-	26	5199	c.4227G>A	c.(4225-4227)ATG>ATA	p.M1409I	LRP1B_uc010fnl.1_Missense_Mutation_p.M591I	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1409	Extracellular (Potential).|LDL-receptor class B 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGCACCACTCATAGAGGCAG	0.368										TSP Lung(27;0.18)			10	116					0	0	0	0	T	141625775	T	T	141625775	3	4	65	1	0	0	0	0	1	0	0	0	9005	826	29	2	9836	2	LRP1B	2	141625775	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	5880146	141625775	101573598	89	12920											
KYNU	8942	broad.mit.edu	37	chr2	143676239	143676239	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcttgggaaattctcttggCcttcaaccaaaaatggttaa	12	14	7	8	0	3	0	1	0	2	0	4	1	3	1	2	3	1	1	2	3	5	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:143676239C>A	uc002tvl.2	+	3	361	c.231C>A	c.(229-231)GGC>GGA	p.G77G	KYNU_uc002tvk.2_Silent_p.G77G|KYNU_uc010fnm.2_Silent_p.G77G	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	77					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	ATTCTCTTGGCCTTCAACCAA	0.279													9	57					1.12685e-05	1.16776e-05	1	0	A	143676239	A	A	143676239	2	1	65	1	0	0	0	0	0	0	0	1	8627	726	26	4		4	KYNU	2	143676239	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2050464	143676239	99523134	90	12921											
KCNH7	90134	broad.mit.edu	37	chr2	163374657	163374658	+	Frame_Shift_Ins	INS	-	A	A																															agaccagggaatttgaacccINSaaaaaatttccctataaatg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:163374657_163374658insA	uc002uch.1	-	4	686_687	c.474_475insT	c.(472-477)TTTGGGfs	p.F158fs	KCNH7_uc002uci.2_Frame_Shift_Ins_p.F158fs	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	158_159	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	AATTTGAACCCAAAAAATTTCC	0.381													---	---	---								A	163374658	A	A	163374657	7	5	65	1	0	1	1	0	0	0	0	0	8076	594	21	0	3233	0	KCNH7	2	163374657	Frame_Shift_Ins	INS	-	TCGA-CN-5369-01A-01D-1434-08	19698418	163374657	79824716	91	12922											
SCN3A	6328	broad.mit.edu	37	chr2	166032878	166032878	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcggaagctttcaggtccTgggggtaccaacagtgcctg	8	8	15	10	1	1	0	1	0	0	0	2	1	2	1	3	5	4	2	3	5	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:166032878T>C	uc002ucx.2	-	3	519	c.27A>G	c.(25-27)CCA>CCG	p.P9P	SCN3A_uc002ucy.2_Silent_p.P9P|SCN3A_uc002ucz.2_Silent_p.P9P	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	9						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTTCAGGTCCTGGGGGTACCA	0.423													13	175					0	0	0	0	C	166032878	C	C	166032878	2	2	65	1	0	0	0	0	0	0	0	1	13983	1567	55	5		5	SCN3A	2	166032878	Silent	SNP	T	TCGA-CN-5369-01A-01D-1434-08	2658221	166032878	77166495	92	12923											
FASTKD1	79675	broad.mit.edu	37	chr2	170428478	170428478	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctctccaggagaatggacaaAtagctcttagacgaagcata	15	8	9	9	1	2	2	0	0	2	2	3	5	2	3	1	2	2	2	1	2	6	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:170428478A>C	uc002uev.3	-	2	450	c.62T>G	c.(61-63)ATT>AGT	p.I21S	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.I7S|FASTKD1_uc002uey.2_Missense_Mutation_p.I7S	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	21					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						GAATGGACAAATAGCTCTTAG	0.358													14	91					0	0	0	0	C	170428478	C	C	170428478	3	2	65	1	0	0	0	0	1	0	0	0	5717	101	4	5	2537	5	FASTKD1	2	170428478	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	4395600	170428478	72770895	93	12924											
PHOSPHO2	493911	broad.mit.edu	37	chr2	170558169	170558169	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtttggtcctcaggtgttGatataatttctcatttacaa	10	18	7	6	0	2	1	2	1	1	0	4	1	3	1	1	2	1	2	1	2	5	8			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:170558169G>C	uc002ufg.2	+	4	1076	c.688G>C	c.(688-690)GAT>CAT	p.D230H	KLHL23_uc002ufh.1_Intron	NM_001008489	NP_001008489	Q8TCD6	PHOP2_HUMAN	phosphatase, orphan 2	230							metal ion binding|pyridoxal phosphatase activity			skin(1)	1						CTCAGGTGTTGATATAATTTC	0.264													16	106					0	0	0	0	C	170558169	C	C	170558169	3	2	65	1	0	0	0	0	1	0	0	0	11912	1290	45	2	690	2	PHOSPHO2	2	170558169	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	129691	170558169	72641204	94	12925											
HOXD8	3234	broad.mit.edu	37	chr2	176995417	176995417	+	Frame_Shift_Del	DEL	C	-	-																															ggccgctgcctaccaggccgCcccccctcctcctccgcatc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:176995417delC	uc002uko.2	+	1	941	c.323delC	c.(322-324)GCCfs	p.A108fs	uc002ukl.1_5'Flank|uc002ukm.1_5'Flank|HOXD8_uc002ukn.2_Intron|HOXD8_uc002ukp.2_Frame_Shift_Del_p.A108fs	NM_019558	NP_062458	P13378	HXD8_HUMAN	homeobox D8	108					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		TACCAGGCCGccccccctcct	0.557													---	---	---								-	176995417	-	-	176995417	7	5	65	1	0	1	0	1	0	0	0	0	7364	739	26	0	325	0	HOXD8	2	176995417	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	6437248	176995417	66203956	95	12926											
ITGA4	3676	broad.mit.edu	37	chr2	182350666	182350666	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtgacaaatatgctgcaaGatttggggaatctatagtta	15	12	10	4	0	1	2	0	1	1	1	1	3	1	3	0	2	2	3	0	2	8	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:182350666G>A	uc002unu.2	+	10	1863	c.1100G>A	c.(1099-1101)AGA>AAA	p.R367K	ITGA4_uc010zfl.1_Missense_Mutation_p.R367K	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	367	FG-GAP 6.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TATGCTGCAAGATTTGGGGAA	0.363													16	140					0	0	0	0	A	182350666	A	A	182350666	3	1	65	1	0	0	0	0	1	0	0	0	7917	942	33	2	1138	2	ITGA4	2	182350666	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	5355249	182350666	60848707	96	12927											
CASP8	841	broad.mit.edu	37	chr2	202141631	202141631	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacaattttgcaaaagcaCgggagaaagtgcccaaactt	16	8	8	9	1	1	1	1	0	0	1	1	2	1	1	1	1	4	2	1	1	5	3	rs17860424		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:202141631C>T	uc002uxr.1	+	8	951	c.742C>T	c.(742-744)CGG>TGG	p.R248W	CASP8_uc002uxo.1_Missense_Mutation_p.T226M|CASP8_uc002uxp.1_Missense_Mutation_p.R265W|CASP8_uc002uxq.1_Missense_Mutation_p.R233W|CASP8_uc002uxt.1_Missense_Mutation_p.R307W|CASP8_uc002uxu.1_RNA|CASP8_uc002uxv.1_Missense_Mutation_p.R233W|CASP8_uc002uxw.1_Missense_Mutation_p.R233W|CASP8_uc002uxy.1_Missense_Mutation_p.R248W|CASP8_uc002uxx.1_Missense_Mutation_p.R233W|CASP8_uc010ftf.2_Intron|CASP8_uc010fte.1_Missense_Mutation_p.T108M	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	248					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TGCAAAAGCACGGGAGAAAGT	0.373										HNSCC(4;0.00038)			17	94					0	0	0	0	T	202141631	T	T	202141631	3	4	65	1	0	0	0	0	1	0	0	0	2689	536	19	1	1045	1	CASP8	2	202141631	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	19790965	202141631	41057742	97	12928											
STRADB	55437	broad.mit.edu	37	chr2	202342454	202342454	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggcatagggctgtgtatGatttcccacagttcagcaca	11	10	11	9	0	1	2	1	1	0	1	2	2	2	2	1	2	1	5	1	2	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:202342454G>C	uc002uyd.3	+	8	1026	c.661G>C	c.(661-663)GAT>CAT	p.D221H		NM_018571	NP_061041	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta	221	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			skin(2)|stomach(1)|lung(1)	4						GGCTGTGTATGATTTCCCACA	0.522													28	208					0	0	0	0	C	202342454	C	C	202342454	3	2	65	1	0	0	0	0	1	0	0	0	15391	1290	45	2	687	2	STRADB	2	202342454	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	200823	202342454	40856919	98	12929											
MAP2	4133	broad.mit.edu	37	chr2	210574652	210574652	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atacagggtcagagccaattCgcagagcagggaagagtggt	13	6	15	7	1	1	3	1	0	0	3	2	4	1	4	1	3	3	2	1	3	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:210574652C>T	uc002vde.1	+	12	4995	c.4747C>T	c.(4747-4749)CGC>TGC	p.R1583C	MAP2_uc002vdd.1_Missense_Mutation_p.R284C|MAP2_uc002vdf.1_Missense_Mutation_p.R227C|MAP2_uc002vdg.1_Missense_Mutation_p.R227C|MAP2_uc002vdh.1_Missense_Mutation_p.R284C|MAP2_uc002vdi.1_Missense_Mutation_p.R1579C	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1583					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGAGCCAATTCGCAGAGCAGG	0.498													14	116					0	0	0	0	T	210574652	T	T	210574652	3	4	65	1	0	0	0	0	1	0	0	0	9288	884	31	1	4956	1	MAP2	2	210574652	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	8232198	210574652	32624721	99	12930											
CUL3	8452	broad.mit.edu	37	chr2	225365164	225365164	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgggccaatatcctgtcGtgagcacccggactgtaaga	10	8	13	10	2	0	2	0	1	0	1	2	4	1	3	3	2	1	2	3	2	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:225365164G>A	uc002vny.2	-	11	1910	c.1526C>T	c.(1525-1527)ACG>ATG	p.T509M	CUL3_uc010zls.1_Missense_Mutation_p.T443M|CUL3_uc010fwy.1_Missense_Mutation_p.T515M|CUL3_uc002vnz.1_Translation_Start_Site	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	509					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ATATCCTGTCGTGAGCACCCG	0.423													11	194					0	0	0	0	A	225365164	A	A	225365164	3	1	65	1	0	0	0	0	1	0	0	0	4073	1145	40	1	804	1	CUL3	2	225365164	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	14790512	225365164	17834209	100	12931											
DOCK10	55619	broad.mit.edu	37	chr2	225668859	225668859	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agagacctgatgtctggcagGaaggattggatcctttgaga	11	10	14	6	0	1	3	0	2	1	2	2	8	2	6	2	4	0	1	2	4	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:225668859G>A	uc010fwz.1	-	39	4477	c.4238C>T	c.(4237-4239)TCC>TTC	p.S1413F	DOCK10_uc002vob.2_Missense_Mutation_p.S1407F|DOCK10_uc002voa.2_Missense_Mutation_p.S69F|DOCK10_uc002voc.2_Missense_Mutation_p.S267F	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1413							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGTCTGGCAGGAAGGATTGGA	0.373													5	66					0	0	0	0	A	225668859	A	A	225668859	3	1	65	1	0	0	0	0	1	0	0	0	4707	1174	41	2	2394	2	DOCK10	2	225668859	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	303695	225668859	17530514	101	12932											
SPHKAP	80309	broad.mit.edu	37	chr2	228881385	228881385	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttagaatctaaagggctgtgGtttgtaagagaagcagtttt	12	14	12	3	0	1	2	0	0	1	2	1	3	1	2	0	2	1	5	0	2	6	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:228881385G>A	uc002vpq.2	-	7	4232	c.4185C>T	c.(4183-4185)AAC>AAT	p.N1395N	SPHKAP_uc002vpp.2_Silent_p.N1395N|SPHKAP_uc010zlx.1_Silent_p.N1395N	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1395						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AAGGGCTGTGGTTTGTAAGAG	0.463													23	188					0	0	0	0	A	228881385	A	A	228881385	2	1	65	1	0	0	0	0	0	0	0	1	15114	1252	44	4		4	SPHKAP	2	228881385	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3212526	228881385	14317988	102	12933											
SPHKAP	80309	broad.mit.edu	37	chr2	228883163	228883163	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggggttcttgaagaggcCtggcctcactccacccttgt	5	11	12	13	1	2	2	1	1	1	1	3	2	3	2	4	4	0	1	4	4	1	3	rs146520315	byFrequency	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:228883163C>A	uc002vpq.2	-	7	2454	c.2407G>T	c.(2407-2409)GGC>TGC	p.G803C	SPHKAP_uc002vpp.2_Missense_Mutation_p.G803C|SPHKAP_uc010zlx.1_Missense_Mutation_p.G803C	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	803						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTGAAGAGGCCTGGCCTCACT	0.463													111	783					4.37143e-48	4.86747e-48	1	0	A	228883163	A	A	228883163	3	1	65	1	0	0	0	0	1	0	0	0	15114	681	24	4	2719	4	SPHKAP	2	228883163	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1778	228883163	14316210	103	12934											
TRIP12	9320	broad.mit.edu	37	chr2	230724116	230724116	+	Frame_Shift_Del	DEL	T	-	-																															gtatgctgaagtgcttttggTttttttgcagagctaggaga																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:230724116delT	uc002vpw.1	-	3	382	c.273delA	c.(271-273)AAAfs	p.K91fs	TRIP12_uc002vpx.1_Frame_Shift_Del_p.K133fs|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Frame_Shift_Del_p.K91fs	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	91					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GTGCTTTTGGTTTTTTTGCAG	0.433													---	---	---								-	230724116	-	-	230724116	7	5	65	1	0	1	0	1	0	0	0	0	16623	1722	60	0	5861	0	TRIP12	2	230724116	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	1840953	230724116	12475257	104	12935											
PRR21	643905	broad.mit.edu	37	chr2	240981426	240981426	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgaagagacgtggatgaaGaggcatggacgaagggccgt	12	5	19	5	3	0	4	0	2	0	2	0	8	0	6	1	5	0	1	1	5	3	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr2:240981426G>C	uc010zod.1	-	1	974	c.974C>G	c.(973-975)TCT>TGT	p.S325C		NM_001080835	NP_001074304	Q8WXC7	PRR21_HUMAN	proline rich 21	325										ovary(1)|skin(1)	2						CGTGGATGAAGAGGCATGGAC	0.597													35	227					0	0	0	0	C	240981426	C	C	240981426	3	2	65	1	0	0	0	0	1	0	0	0	12654	942	33	2	198	2	PRR21	2	240981426	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	10257310	240981426	2217947	105	12936											
EDEM1	9695	broad.mit.edu	37	chr3	5249942	5249942	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggaatccacatatctcctCtaccaggtactagagttgtg	10	12	9	10	0	2	1	0	0	2	1	4	2	3	2	3	2	2	2	3	2	5	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:5249942C>G	uc003bqi.2	+	8	1635	c.1503C>G	c.(1501-1503)CTC>CTG	p.L501L	EDEM1_uc011asz.1_Silent_p.L279L|EDEM1_uc003bqh.2_Silent_p.L501L	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	501	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		CATATCTCCTCTACCAGGTAC	0.463													7	140					0	0	0	0	G	5249942	G	G	5249942	2	3	65	1	0	0	0	0	0	0	0	1	4933	900	32	2		2	EDEM1	3	5249942	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08		5249942	192772488	106	12937											
TTLL3	26140	broad.mit.edu	37	chr3	9862377	9862377	+	Frame_Shift_Del	DEL	C	-	-																															ggaggccccgctgtacctcaCccccgagggctggtccctct																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:9862377delC	uc003btg.2	+	7	893	c.677delC	c.(676-678)ACCfs	p.T226fs	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_Frame_Shift_Del_p.T193fs|TTLL3_uc003btf.3_Frame_Shift_Del_p.T14fs|TTLL3_uc010hco.1_Frame_Shift_Del_p.T162fs|TTLL3_uc003bth.3_Frame_Shift_Del_p.T14fs|TTLL3_uc011atj.1_Frame_Shift_Del_p.T162fs|TTLL3_uc003btj.3_Frame_Shift_Del_p.T14fs|TTLL3_uc003bti.3_Frame_Shift_Del_p.T14fs	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	226	TTL.				axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					CTGTACCTCACCCCCGAGGGC	0.602													---	---	---								-	9862377	-	-	9862377	7	5	65	1	0	1	0	1	0	0	0	0	16796	507	18	0	699	0	TTLL3	3	9862377	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	4612435	9862377	188160053	107	12938											
C3orf24	115795	broad.mit.edu	37	chr3	10146171	10146171	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagacagaatctactccactGaggcggatgggctggggctt	10	8	14	9	1	1	3	0	1	1	2	2	4	2	4	1	5	1	2	1	5	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:10146171G>A	uc003buz.2	-	2	513	c.288C>T	c.(286-288)CTC>CTT	p.L96L	C3orf24_uc003bva.1_Silent_p.L96L	NM_173472	NP_775743	Q96PS1	CC024_HUMAN	hypothetical protein LOC115795	96											0				OV - Ovarian serous cystadenocarcinoma(96;0.196)		CTACTCCACTGAGGCGGATGG	0.517													14	129					0	0	0	0	A	10146171	A	A	10146171	2	1	65	1	0	0	0	0	0	0	0	1	2227	1277	45	2		2	C3orf24	3	10146171	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	283794	10146171	187876259	108	12939											
HRH1	3269	broad.mit.edu	37	chr3	11302128	11302128	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cactgaaccccctcatctacCccttgtgcaatgagaacttc	10	10	5	16	0	2	2	1	2	1	1	3	3	2	2	4	0	4	1	4	0	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:11302128C>T	uc010hdr.2	+	2	1747	c.1405C>T	c.(1405-1407)CCC>TCC	p.P469S	HRH1_uc010hds.2_Missense_Mutation_p.P469S|HRH1_uc010hdt.2_Missense_Mutation_p.P469S|HRH1_uc003bwb.3_Missense_Mutation_p.P469S	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	469	Helical; Name=7; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	CCTCATCTACCCCTTGTGCAA	0.458													29	294					0	0	0	0	T	11302128	T	T	11302128	3	4	65	1	0	0	0	0	1	0	0	0	7394	623	22	4	1407	4	HRH1	3	11302128	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1155957	11302128	186720302	109	12940											
STT3B	201595	broad.mit.edu	37	chr3	31665334	31665334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctagtccaagtgtagtcctgGcctcatacaatcatgatggg	10	11	10	10	0	2	1	2	1	0	0	4	1	4	1	3	2	1	1	3	2	5	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:31665334G>A	uc011axe.1	+	11	1708	c.1708G>A	c.(1708-1710)GCC>ACC	p.A570T		NM_178862	NP_849193	Q8TCJ2	STT3B_HUMAN	source of immunodominant MHC-associated	570					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0						TGTAGTCCTGGCCTCATACAA	0.373													14	117					0	0	0	0	A	31665334	A	A	31665334	3	1	65	1	0	0	0	0	1	0	0	0	15400	1203	42	4	1750	4	STT3B	3	31665334	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	20363206	31665334	166357096	110	12941											
ZNF860	344787	broad.mit.edu	37	chr3	32030595	32030595	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacgtgaggaagcagctcaGaagaggaaagaaaaggagcc	17	4	14	6	1	1	4	1	1	0	3	1	7	1	7	1	3	4	2	1	3	6	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:32030595G>C	uc011axg.1	+	2	573	c.24G>C	c.(22-24)CAG>CAC	p.Q8H		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAGCAGCTCAGAAGAGGAAAG	0.448													10	104					0	0	0	0	C	32030595	C	C	32030595	3	2	65	1	0	0	0	0	1	0	0	0	18261	933	33	2	26	2	ZNF860	3	32030595	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	365261	32030595	165991835	111	12942											
TMPPE	643853	broad.mit.edu	37	chr3	33135566	33135566	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgcaagcgaagcagccaaCgccaggccctgagctcaagg	11	3	13	14	2	1	1	1	1	0	0	1	2	1	1	3	2	6	4	3	2	4	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:33135566C>T	uc003cfk.2	-	2	313	c.122G>A	c.(121-123)CGT>CAT	p.R41H	GLB1_uc003cfh.1_Intron|GLB1_uc003cfi.1_Intron|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Intron|TMPPE_uc011axl.1_Intron	NM_001039770	NP_001034859	Q6ZT21	TMPPE_HUMAN	transmembrane protein with	41						integral to membrane	metal ion binding				0						AAGCAGCCAACGCCAGGCCCT	0.602													6	63					0	0	0	0	T	33135566	T	T	33135566	3	4	65	1	0	0	0	0	1	0	0	0	16304	536	19	1	1243	1	TMPPE	3	33135566	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1104971	33135566	164886864	112	12943											
MLH1	4292	broad.mit.edu	37	chr3	37059048	37059048	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccatagaaacagtgtatgCagcctatttgcccaaaaaca	16	8	7	10	0	0	1	0	0	0	1	0	1	0	1	3	0	6	2	3	0	6	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:37059048C>T	uc003cgl.2	+	10	902	c.842C>T	c.(841-843)GCA>GTA	p.A281V	MLH1_uc011aye.1_Missense_Mutation_p.A40V|MLH1_uc011ayb.1_Missense_Mutation_p.A40V|MLH1_uc010hge.2_Missense_Mutation_p.A281V|MLH1_uc003cgn.3_Missense_Mutation_p.A40V|MLH1_uc011ayc.1_Missense_Mutation_p.A183V|MLH1_uc011ayd.1_Missense_Mutation_p.A40V|MLH1_uc003cgo.2_Missense_Mutation_p.A40V|MLH1_uc010hgg.1_Intron|MLH1_uc010hgh.1_Intron|MLH1_uc010hgi.1_5'UTR|MLH1_uc010hgj.1_Intron|MLH1_uc010hgk.2_Intron|MLH1_uc010hgl.1_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	281			Missing (in HNPCC2).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						ACAGTGTATGCAGCCTATTTG	0.428		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				21	153					0	0	0	0	T	37059048	T	T	37059048	3	4	65	1	0	0	0	0	1	0	0	0	9670	710	25	4	880	4	MLH1	3	37059048	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3923482	37059048	160963382	113	12944											
RTP3	83597	broad.mit.edu	37	chr3	46542332	46542332	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtaggaacttaagcattttCtgctgttgtgtcattctcat	8	18	8	7	0	3	0	2	0	2	0	4	1	3	1	0	1	3	4	0	1	3	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:46542332C>G	uc003cps.1	+	2	710	c.642C>G	c.(640-642)TTC>TTG	p.F214L		NM_031440	NP_113628	Q9BQQ7	RTP3_HUMAN	transmembrane protein 7	214	Helical; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		TAAGCATTTTCTGCTGTTGTG	0.328													12	173					0	0	0	0	G	46542332	G	G	46542332	3	3	65	1	0	0	0	0	1	0	0	0	13800	912	32	2	648	2	RTP3	3	46542332	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	9483284	46542332	151480098	114	12945											
PTPN23	25930	broad.mit.edu	37	chr3	47448072	47448072	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaagaaacttgtgcagatGaagatctactacttcgcagc	13	10	10	8	1	1	4	0	1	1	3	2	5	1	5	0	1	5	2	0	1	5	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:47448072G>A	uc003crf.1	+	8	825	c.729G>A	c.(727-729)ATG>ATA	p.M243I	PTPN23_uc011baw.1_Missense_Mutation_p.M208I|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Missense_Mutation_p.M113I	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	243	BRO1.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TTGTGCAGATGAAGATCTACT	0.617													5	66					0	0	0	0	A	47448072	A	A	47448072	3	1	65	1	0	0	0	0	1	0	0	0	12853	1290	45	2	759	2	PTPN23	3	47448072	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	905740	47448072	150574358	115	12946											
P4HTM	54681	broad.mit.edu	37	chr3	49042369	49042369	+	Frame_Shift_Del	DEL	G	-	-																															caggttgttcgatatggtgaGgggggccactaccatgccca																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:49042369delG	uc003cvg.2	+	6	1312	c.963delG	c.(961-963)GAGfs	p.E321fs	P4HTM_uc003cvh.2_Frame_Shift_Del_p.E321fs|WDR6_uc011bbx.1_5'Flank|WDR6_uc003cvj.2_5'Flank|WDR6_uc011bby.1_5'Flank|WDR6_uc010hkn.2_5'Flank|WDR6_uc011bbz.1_5'Flank	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	321	Lumenal (Potential).|Fe2OG dioxygenase.					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	GATATGGTGAGGGGGGCCACT	0.617													---	---	---								-	49042369	-	-	49042369	7	5	65	1	0	1	0	1	0	0	0	0	11414	991	35	0	985	0	P4HTM	3	49042369	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	1594297	49042369	148980061	116	12947											
AMT	275	broad.mit.edu	37	chr3	49455119	49455119	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcgccacattcttcttcaGagagggggaggggcagccac	9	7	13	12	1	3	1	1	0	2	1	4	3	3	2	2	4	1	1	2	4	0	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:49455119G>A	uc003cww.2	-	9	1195	c.1066C>T	c.(1066-1068)CTG>TTG	p.L356L	AMT_uc011bcn.1_3'UTR|AMT_uc003cwx.2_Silent_p.L356L|AMT_uc011bco.1_Silent_p.L312L|AMT_uc003cwy.2_Silent_p.L308L|AMT_uc011bcp.1_Silent_p.L259L|AMT_uc011bcq.1_Silent_p.L300L	NM_000481	NP_000472	P48728	GCST_HUMAN	aminomethyltransferase isoform 1 precursor	356					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TTCTTCTTCAGAGAGGGGGAG	0.592													11	123					0	0	0	0	A	49455119	A	A	49455119	2	1	65	1	0	0	0	0	0	0	0	1	589	933	33	2		2	AMT	3	49455119	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	412750	49455119	148567311	117	12948											
BSN	8927	broad.mit.edu	37	chr3	49698774	49698774	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaactatgaggtgatcgccAgccccgttgtgcccatgtct	7	10	10	14	2	1	2	0	2	1	0	2	2	1	2	5	1	3	1	5	1	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:49698774A>G	uc003cxe.3	+	6	9610	c.9496A>G	c.(9496-9498)AGC>GGC	p.S3166G		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3166					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGTGATCGCCAGCCCCGTTGT	0.627													7	83					0	0	0	0	G	49698774	G	G	49698774	3	3	65	1	0	0	0	0	1	0	0	0	1535	188	7	5	9518	5	BSN	3	49698774	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	243655	49698774	148323656	118	12949											
RBM6	10180	broad.mit.edu	37	chr3	50006080	50006080	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagaagcatggagtaccgtGatgtggatcataggctgcca	12	8	13	8	1	1	2	1	1	0	1	1	4	1	4	2	3	3	3	2	3	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:50006080G>A	uc003cyc.2	+	3	1355	c.1222G>A	c.(1222-1224)GAT>AAT	p.D408N	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_Intron|RBM6_uc003cyd.2_Intron|RBM6_uc003cye.2_Intron|RBM6_uc011bdi.1_Intron|RBM6_uc010hld.1_Intron|RBM6_uc010hle.1_Intron|RBM6_uc010hlf.1_Intron	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	408					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		GGAGTACCGTGATGTGGATCA	0.522													10	73					0	0	0	0	A	50006080	A	A	50006080	3	1	65	1	0	0	0	0	1	0	0	0	13209	1290	45	2	1228	2	RBM6	3	50006080	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	307306	50006080	148016350	119	12950											
RBM6	10180	broad.mit.edu	37	chr3	50006127	50006127	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatgtttggctatggccaGagcaagtcttttccagaggg	9	11	13	8	0	1	3	0	0	1	3	2	3	2	3	2	3	1	3	2	3	2	4	rs147351457		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:50006127G>T	uc003cyc.2	+	3	1402	c.1269G>T	c.(1267-1269)CAG>CAT	p.Q423H	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_Intron|RBM6_uc003cyd.2_Intron|RBM6_uc003cye.2_Intron|RBM6_uc011bdi.1_Intron|RBM6_uc010hld.1_Intron|RBM6_uc010hle.1_Intron|RBM6_uc010hlf.1_Intron	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	423					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		GCTATGGCCAGAGCAAGTCTT	0.473													8	61					5.4927e-09	5.87635e-09	1	0	T	50006127	T	T	50006127	3	4	65	1	0	0	0	0	1	0	0	0	13209	933	33	2	1275	2	RBM6	3	50006127	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	47	50006127	148016303	120	12951											
NISCH	11188	broad.mit.edu	37	chr3	52522252	52522252	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggctgttgctcacgccccAgcacctcaacgtcatcaagg	8	8	9	16	2	4	0	4	0	0	0	4	0	4	0	3	2	3	4	3	2	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:52522252A>G	uc011beg.1	+	17	2816	c.2744A>G	c.(2743-2745)CAG>CGG	p.Q915R	NISCH_uc003ded.3_Missense_Mutation_p.Q915R|NISCH_uc003dee.3_Missense_Mutation_p.Q404R|NISCH_uc003deg.1_RNA|NISCH_uc003deh.3_5'Flank	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	915					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CTCACGCCCCAGCACCTCAAC	0.652													7	64					0	0	0	0	G	52522252	G	G	52522252	3	3	65	1	0	0	0	0	1	0	0	0	10486	188	7	5	2806	5	NISCH	3	52522252	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	2516125	52522252	145500178	121	12952											
PRKCD	5580	broad.mit.edu	37	chr3	53220653	53220653	+	Frame_Shift_Del	DEL	G	-	-																															ttgtgatggagttcctcaacGggggggacctgatgtaccac																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:53220653delG	uc003dgl.2	+	14	1647	c.1294delG	c.(1294-1296)GGGfs	p.G432fs	PRKCD_uc003dgm.2_Frame_Shift_Del_p.G432fs	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	432	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		GTTCCTCAACGGGGGGGACCT	0.602													---	---	---								-	53220653	-	-	53220653	7	5	65	1	0	1	0	1	0	0	0	0	12571	1116	39	0	1340	0	PRKCD	3	53220653	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	698401	53220653	144801777	122	12953											
LRTM1	57408	broad.mit.edu	37	chr3	54958711	54958711	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcaattgcatttccagaggTtgtccttgagaagtaaaagc	12	11	11	7	0	0	2	0	1	0	2	2	3	2	2	2	2	2	4	2	2	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:54958711T>C	uc003dhl.2	-	2	673	c.539A>G	c.(538-540)AAC>AGC	p.N180S	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	180	Extracellular (Potential).|LRRCT.					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		TTTCCAGAGGTTGTCCTTGAG	0.463													19	206					0	0	0	0	C	54958711	C	C	54958711	3	2	65	1	0	0	0	0	1	0	0	0	9094	1725	60	5	506	5	LRTM1	3	54958711	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	1738058	54958711	143063719	123	12954											
WNT5A	7474	broad.mit.edu	37	chr3	55504433	55504433	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttgccccggctgttgagcCgcatggccgccgcgctgtcg	3	8	14	16	6	0	1	0	1	0	0	1	1	0	1	5	2	2	4	5	2	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:55504433C>A	uc003dhn.2	-	5	1148	c.830G>T	c.(829-831)CGG>CTG	p.R277L	WNT5A_uc003dhm.2_Missense_Mutation_p.R262L|WNT5A_uc010hmw.2_Missense_Mutation_p.R262L|WNT5A_uc010hmx.2_Missense_Mutation_p.R188L	NM_003392	NP_003383	P41221	WNT5A_HUMAN	wingless-type MMTV integration site family,	277					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		GCTGTTGAGCCGCATGGCCGC	0.612													4	14					0.00909568	0.00912474	1	0	A	55504433	A	A	55504433	3	1	65	1	0	0	0	0	1	0	0	0	17459	652	23	3	316	3	WNT5A	3	55504433	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	545722	55504433	142517997	124	12955											
FAM116A	201627	broad.mit.edu	37	chr3	57613942	57613942	+	Nonstop_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaaaatcttggcaaatatCatgtcatgcccgttttgagc	11	13	9	8	1	3	1	2	1	1	0	3	2	3	2	1	2	2	2	1	2	4	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:57613942C>G	uc003dja.2	-	20	1897	c.1826G>C	c.(1825-1827)TGA>TCA	p.*609S		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	609										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		TGGCAAATATCATGTCATGCC	0.438													17	206					0	0	0	0	G	57613942	G	G	57613942	4	3	65	1	0	0	0	0	0	0	0	0	5435	837	29	2	4	2	FAM116A	3	57613942	Nonstop_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2109509	57613942	140408488	125	12956											
SHQ1	55164	broad.mit.edu	37	chr3	72799729	72799729	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctcagatggactatctttGagttcatcttgttctgaatc	8	17	8	8	0	5	3	2	2	4	1	7	4	5	4	0	1	0	2	0	1	2	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:72799729G>A	uc003dpf.2	-	11	1547	c.1440C>T	c.(1438-1440)CTC>CTT	p.L480L	SHQ1_uc010hod.2_Silent_p.L391L	NM_018130	NP_060600	Q6PI26	SHQ1_HUMAN	SHQ1 homolog	480	Ser-rich.				ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			ovary(2)|large_intestine(1)	3		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		GACTATCTTTGAGTTCATCTT	0.468													11	131					0	0	0	0	A	72799729	A	A	72799729	2	1	65	1	0	0	0	0	0	0	0	1	14357	1277	45	2		2	SHQ1	3	72799729	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	15185787	72799729	125222701	126	12957											
GXYLT2	727936	broad.mit.edu	37	chr3	73004381	73004381	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagccatggcccctgagcacGaaatccccaagattggctgg	10	6	11	14	1	0	2	0	1	0	1	1	3	1	2	5	3	2	2	5	3	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:73004381G>C	uc003dpg.2	+	4	733	c.733G>C	c.(733-735)GAA>CAA	p.E245Q		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	245	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						CCCTGAGCACGAAATCCCCAA	0.493													6	51					0	0	0	0	C	73004381	C	C	73004381	3	2	65	1	0	0	0	0	1	0	0	0	6943	1059	37	3	747	3	GXYLT2	3	73004381	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	204652	73004381	125018049	127	12958											
STXBP5L	9515	broad.mit.edu	37	chr3	120977960	120977960	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttattcaattggtgtgggtaGatggtgaacctccacaacag	11	12	11	7	0	1	2	1	1	0	1	2	2	2	2	2	3	2	1	2	3	5	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:120977960G>C	uc003eec.3	+	18	2043	c.1903G>C	c.(1903-1905)GAT>CAT	p.D635H	STXBP5L_uc011bji.1_Missense_Mutation_p.D635H	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	635					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GGTGTGGGTAGATGGTGAACC	0.348													8	113					0	0	0	0	C	120977960	C	C	120977960	3	2	65	1	0	0	0	0	1	0	0	0	15423	942	33	2	1969	2	STXBP5L	3	120977960	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	47973579	120977960	77044470	128	12959											
KALRN	8997	broad.mit.edu	37	chr3	124397074	124397074	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atactctacgcatgagaaagCgggcggaagtggagaacacg	14	5	14	8	4	1	2	0	1	1	2	1	5	1	3	0	3	4	1	0	3	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:124397074C>T	uc003ehg.2	+	50	7358	c.7231C>T	c.(7231-7233)CGG>TGG	p.R2411W	KALRN_uc003ehk.2_Missense_Mutation_p.R714W	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2410					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CATGAGAAAGCGGGCGGAAGT	0.483													14	148					0	0	0	0	T	124397074	T	T	124397074	3	4	65	1	0	0	0	0	1	0	0	0	8014	759	27	1	7585	1	KALRN	3	124397074	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3419114	124397074	73625356	129	12960											
SLC12A8	84561	broad.mit.edu	37	chr3	124839464	124839464	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agatgccaacagctgccaggGagcccgggggaatgctggcg	9	4	17	11	2	0	1	0	0	0	1	0	3	0	3	3	4	6	2	3	4	2	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:124839464G>A	uc003ehv.3	-	7	914	c.803C>T	c.(802-804)TCC>TTC	p.S268F	SLC12A8_uc003ehw.3_Missense_Mutation_p.S297F|SLC12A8_uc010hrz.1_Missense_Mutation_p.S133F|SLC12A8_uc003eht.3_Missense_Mutation_p.S69F|SLC12A8_uc003ehu.3_Missense_Mutation_p.S21F|SLC12A8_uc010hry.2_Missense_Mutation_p.S21F	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	268	Helical; (Potential).				potassium ion transport	integral to membrane	symporter activity				0						AGCTGCCAGGGAGCCCGGGGG	0.597													4	35					0	0	0	0	A	124839464	A	A	124839464	3	1	65	1	0	0	0	0	1	0	0	0	14454	1174	41	2	1373	2	SLC12A8	3	124839464	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	442390	124839464	73182966	130	12961											
EEFSEC	60678	broad.mit.edu	37	chr3	128060436	128060436	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggagcagtacctgtccaagGatttgacaccagcagtgaca	13	7	11	10	0	0	2	0	2	0	0	1	4	1	4	3	2	3	3	3	2	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:128060436G>T	uc003eki.2	+	5	1185	c.1147G>T	c.(1147-1149)GAT>TAT	p.D383Y	EEFSEC_uc003ekj.2_Missense_Mutation_p.D328Y	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	383						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						CCTGTCCAAGGATTTGACACC	0.532													15	83					7.93312e-07	8.27575e-07	1	0	T	128060436	T	T	128060436	3	4	65	1	0	0	0	0	1	0	0	0	4953	1174	41	2	1165	2	EEFSEC	3	128060436	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3220972	128060436	69961994	131	12962											
GATA2	2624	broad.mit.edu	37	chr3	128204941	128204941	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggaagccgaaaaggtgggagCcagagtgggctgctgtaggg	10	5	20	6	1	0	1	0	0	0	1	0	4	0	3	2	5	3	3	2	5	4	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:128204941C>T	uc003ekm.3	-	4	935	c.500G>A	c.(499-501)GGC>GAC	p.G167D	GATA2_uc003ekn.3_Missense_Mutation_p.G167D|GATA2_uc003eko.2_Missense_Mutation_p.G167D	NM_001145661	NP_001139133	P23769	GATA2_HUMAN	GATA binding protein 2 isoform 1	167					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(13)|lung(1)|skin(1)	15				GBM - Glioblastoma multiforme(114;0.173)		AAGGTGGGAGCCAGAGTGGGC	0.682			Mis		AML(CML blast transformation)								5	24					0	0	0	0	T	128204941	T	T	128204941	3	4	65	1	0	0	0	0	1	0	0	0	6289	739	26	4	958	4	GATA2	3	128204941	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	144505	128204941	69817489	132	12963											
TRIM42	287015	broad.mit.edu	37	chr3	140401600	140401600	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagaactacctgcacgggcGtctcaccaagcgctacatgc	10	6	10	15	4	1	1	1	0	1	1	2	2	1	1	2	1	6	2	2	1	4	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:140401600G>A	uc003eto.1	+	2	829	c.638G>A	c.(637-639)CGT>CAT	p.R213H		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	213						intracellular	zinc ion binding	p.R213H(1)		lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CTGCACGGGCGTCTCACCAAG	0.612													9	169					0	0	0	0	A	140401600	A	A	140401600	3	1	65	1	0	0	0	0	1	0	0	0	16584	1145	40	1	644	1	TRIM42	3	140401600	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	12196659	140401600	57620830	133	12964											
ZIC1	7545	broad.mit.edu	37	chr3	147128155	147128155	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaccatcacccgggccacGtcggctcctattccagcgca	8	7	8	18	4	2	0	2	0	0	0	5	0	4	0	5	2	1	2	5	2	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:147128155G>A	uc003ewe.2	+	1	975	c.256G>A	c.(256-258)GTC>ATC	p.V86I		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	86					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCCGGGCCACGTCGGCTCCTA	0.697													4	42					0	0	0	0	A	147128155	A	A	147128155	3	1	65	1	0	0	0	0	1	0	0	0	17745	1145	40	1	258	1	ZIC1	3	147128155	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6726555	147128155	50894275	134	12965											
NMD3	51068	broad.mit.edu	37	chr3	160968692	160968692	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaaggtgcatcaatgctGacataatgagatgttgtaga	15	10	12	4	0	1	4	1	2	0	3	1	6	1	4	0	1	2	4	0	1	5	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:160968692G>C	uc003feb.1	+	16	1625	c.1506G>C	c.(1504-1506)CTG>CTC	p.L502L	NMD3_uc003fec.2_Intron|NMD3_uc003fed.1_Silent_p.L502L	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	502	Necessary for the nuclear export of the 60S ribosomal subunit.				protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			CATCAATGCTGACATAATGAG	0.433													8	170					0	0	0	0	C	160968692	C	C	160968692	2	2	65	1	0	0	0	0	0	0	0	1	10542	1277	45	2		2	NMD3	3	160968692	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	13840537	160968692	37053738	135	12966											
ECT2	1894	broad.mit.edu	37	chr3	172534484	172534484	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtaacttaaactctaggttAcaagagcattctctttctcc	11	15	5	10	0	3	1	0	0	3	1	5	1	3	1	1	1	4	3	1	1	6	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:172534484A>G	uc003fii.2	+	23	2557	c.2419A>G	c.(2419-2421)ACA>GCA	p.T807A	ECT2_uc003fih.2_Missense_Mutation_p.T806A|ECT2_uc003fij.1_Missense_Mutation_p.T807A|ECT2_uc003fik.1_Missense_Mutation_p.T807A|ECT2_uc003fil.1_Missense_Mutation_p.T838A|ECT2_uc003fim.1_Missense_Mutation_p.T106A	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	807					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			ACTCTAGGTTACAAGAGCATT	0.368													11	66					0	0	0	0	G	172534484	G	G	172534484	3	3	65	1	0	0	0	0	1	0	0	0	4923	391	14	5	2505	5	ECT2	3	172534484	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	11565792	172534484	25487946	136	12967											
SPATA16	83893	broad.mit.edu	37	chr3	172642075	172642075	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccatttgcctcactgtatCttctctggtcagaccgaaag	8	13	7	13	1	4	1	2	0	2	1	6	2	5	1	3	1	1	1	3	1	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:172642075C>G	uc003fin.3	-	8	1419	c.1261G>C	c.(1261-1263)GAT>CAT	p.D421H		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	421					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			CTCACTGTATCTTCTCTGGTC	0.328													9	199					0	0	0	0	G	172642075	G	G	172642075	3	3	65	1	0	0	0	0	1	0	0	0	15067	913	32	2	464	2	SPATA16	3	172642075	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	107591	172642075	25380355	137	12968											
MFN1	55669	broad.mit.edu	37	chr3	179096140	179096140	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttaacaggaattaaataaGcacatagaggatggtatggg	16	10	12	3	0	0	1	0	0	0	1	0	3	0	3	0	4	2	3	0	4	7	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:179096140G>A	uc003fjs.2	+	13	1467	c.1341G>A	c.(1339-1341)AAG>AAA	p.K447K	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Silent_p.K475K|MFN1_uc010hxc.2_Intron	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	447	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			AATTAAATAAGCACATAGAGG	0.318													12	79					0	0	0	0	A	179096140	A	A	179096140	2	1	65	1	0	0	0	0	0	0	0	1	9576	962	34	4		4	MFN1	3	179096140	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6454065	179096140	18926290	138	12969											
B3GNT5	84002	broad.mit.edu	37	chr3	182987617	182987617	+	Frame_Shift_Del	DEL	A	-	-																															tggttagtggcagaagagtcAaaaaatggcagttaattatt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:182987617delA	uc003flk.2	+	2	561	c.31delA	c.(31-33)AAAfs	p.K11fs	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Frame_Shift_Del_p.K11fs|B3GNT5_uc003flm.2_Frame_Shift_Del_p.K11fs	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	11	Cytoplasmic (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CAGAAGAGTCAAAAAATGGCA	0.373													---	---	---								-	182987617	-	-	182987617	7	5	65	1	0	1	0	1	0	0	0	0	1262	131	5	0	33	0	B3GNT5	3	182987617	Frame_Shift_Del	DEL	A	TCGA-CN-5369-01A-01D-1434-08	3891477	182987617	15034813	139	12970											
MASP1	5648	broad.mit.edu	37	chr3	186943271	186943271	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccgagatgctgttcattttCatctgaccggagcctccaat	8	12	9	12	2	3	2	2	1	1	1	4	4	4	3	4	1	2	2	4	1	1	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:186943271C>T	uc003frh.1	-	13	1914	c.1582G>A	c.(1582-1584)GAA>AAA	p.E528K		NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	528	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TGTTCATTTTCATCTGACCGG	0.542													24	265					0	0	0	0	T	186943271	T	T	186943271	3	4	65	1	0	0	0	0	1	0	0	0	9375	835	29	2	533	2	MASP1	3	186943271	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3955654	186943271	11079159	140	12971											
LRCH3	84859	broad.mit.edu	37	chr3	197579467	197579467	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtccacaaaaacagcacccGctcctagatggcgtagatgg	13	6	10	12	2	0	2	0	0	0	2	2	2	2	2	3	2	2	3	3	2	4	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr3:197579467G>A	uc011bul.1	+	13	1571	c.1566G>A	c.(1564-1566)CCG>CCA	p.P522P	LRCH3_uc003fyj.1_Silent_p.P522P|LRCH3_uc011bum.1_Silent_p.P494P|LRCH3_uc011bun.1_Silent_p.P368P|LRCH3_uc003fyk.2_Silent_p.P117P	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	522						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		AACAGCACCCGCTCCTAGATG	0.388													10	190					0	0	0	0	A	197579467	A	A	197579467	2	1	65	1	0	0	0	0	0	0	0	1	8984	1074	38	1		1	LRCH3	3	197579467	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	10636196	197579467	442963	141	12972											
ZNF721	170960	broad.mit.edu	37	chr4	436405	436406	+	Frame_Shift_Del	DEL	CT	-	-																															catacaaagtctttgccacaCtcttcacatttgtaaagttt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:436405_436406delCT	uc003gag.2	-	3	2541_2542	c.1850_1851delAG	c.(1849-1851)GAGfs	p.E617fs	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Frame_Shift_Del_p.E649fs|ZNF721_uc010ibe.2_Frame_Shift_Del_p.E605fs	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	617						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CTTTGCCACACTCTTCACATTT	0.411													---	---	---								-	436406	-	-	436405	7	5	65	1	0	1	0	1	0	0	0	0	18189	564	20	0	924	0	ZNF721	4	436405	Frame_Shift_Del	DEL	CT	TCGA-CN-5369-01A-01D-1434-08		436405	190717871	142	12973											
ZNF721	170960	broad.mit.edu	37	chr4	437477	437477	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttagcaaagcttgaggatGaggaaatgactttgccacat	13	11	11	6	0	0	3	0	3	0	0	0	5	0	5	1	2	3	3	1	2	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:437477G>A	uc003gag.2	-	3	1470	c.779C>T	c.(778-780)TCA>TTA	p.S260L	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.S292L|ZNF721_uc010ibe.2_Missense_Mutation_p.S248L	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	260						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GCTTGAGGATGAGGAAATGAC	0.378													9	87					0	0	0	0	A	437477	A	A	437477	3	1	65	1	0	0	0	0	1	0	0	0	18189	1294	45	2	1996	2	ZNF721	4	437477	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1072	437477	190716799	143	12974											
TACC3	10460	broad.mit.edu	37	chr4	1729444	1729444	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttttaaaagccaacagctCatcaaggaagtggatgccaa	15	9	8	9	0	3	0	2	0	1	0	3	2	3	2	2	2	4	1	2	2	6	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:1729444C>T	uc003gdo.2	+	4	423	c.315C>T	c.(313-315)CTC>CTT	p.L105L	TACC3_uc010ibz.2_Silent_p.L105L|TACC3_uc003gdp.2_Intron	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	105						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			GCCAACAGCTCATCAAGGAAG	0.413													62	517					0	0	0	0	T	1729444	T	T	1729444	2	4	65	1	0	0	0	0	0	0	0	1	15569	813	29	2		2	TACC3	4	1729444	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1291967	1729444	189424832	144	12975											
MRFAP1L1	114932	broad.mit.edu	37	chr4	6711296	6711296	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaactgctcgaaatcctcctCgggctccagcacctccactt	8	9	7	17	2	0	0	0	0	0	0	6	2	4	0	5	1	3	3	5	1	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:6711296C>G	uc003gjn.2	-	1	301	c.61G>C	c.(61-63)GAG>CAG	p.E21Q	MRFAP1L1_uc003gjo.2_Missense_Mutation_p.E21Q	NM_203462	NP_982287	Q96HT8	MR1L1_HUMAN	Morf4 family associated protein 1-like 1	21											0						AAATCCTCCTCGGGCTCCAGC	0.637													7	96					0	0	0	0	G	6711296	G	G	6711296	3	3	65	1	0	0	0	0	1	0	0	0	9815	893	31	3	326	3	MRFAP1L1	4	6711296	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4981852	6711296	184442980	145	12976											
DRD5	1816	broad.mit.edu	37	chr4	9784345	9784345	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacgccatctcttcctcgcTcatcagcttctacatccccg	6	12	4	19	3	4	0	2	0	2	0	8	0	6	0	4	0	3	2	4	0	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:9784345T>C	uc003gmb.3	+	1	1088	c.692T>C	c.(691-693)CTC>CCC	p.L231P		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	231	Helical; Name=5; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TCTTCCTCGCTCATCAGCTTC	0.582													10	93					0	0	0	0	C	9784345	C	C	9784345	3	2	65	1	0	0	0	0	1	0	0	0	4782	1551	54	5	694	5	DRD5	4	9784345	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	3073049	9784345	181369931	146	12977											
TBC1D1	23216	broad.mit.edu	37	chr4	38016216	38016216	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgtccgagttcgacgacacGttttccaagaagttcgaggt	9	10	11	11	6	0	1	0	0	0	1	4	5	2	1	3	1	0	3	3	1	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:38016216G>A	uc003gtb.2	+	3	847	c.504G>A	c.(502-504)ACG>ACA	p.T168T	TBC1D1_uc011byd.1_Silent_p.T168T|TBC1D1_uc010ifd.2_Intron|TBC1D1_uc011byf.1_Silent_p.T39T	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	168						nucleus	Rab GTPase activator activity			ovary(1)	1						TCGACGACACGTTTTCCAAGA	0.617													29	228					0	0	0	0	A	38016216	A	A	38016216	2	1	65	1	0	0	0	0	0	0	0	1	15663	1132	40	1		1	TBC1D1	4	38016216	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	28231871	38016216	153138060	147	12978											
C4orf14	84273	broad.mit.edu	37	chr4	57843646	57843646	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggaggaggcggcagcgcAcctcctctccaggagcggct	8	4	16	13	3	1	0	0	0	1	0	3	4	2	3	3	6	2	3	3	6	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:57843646A>G	uc003hck.2	-	1	181	c.106T>C	c.(106-108)TGC>CGC	p.C36R	POLR2B_uc003hcl.1_5'Flank|POLR2B_uc011cae.1_5'Flank|POLR2B_uc011caf.1_5'Flank	NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	36							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					GCGGCAGCGCACCTCCTCTCC	0.657													6	32					0	0	0	0	G	57843646	G	G	57843646	3	3	65	1	0	0	0	0	1	0	0	0	2261	159	6	5	2018	5	C4orf14	4	57843646	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	19827430	57843646	133310630	148	12979											
ANKRD56	345079	broad.mit.edu	37	chr4	77817771	77817771	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccccggggagtctttgggcCcactgctgctctcctcactg	3	10	11	17	1	3	0	1	0	2	0	4	1	3	1	4	3	2	2	4	3	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:77817771C>A	uc003hki.2	-	1	1232	c.1232G>T	c.(1231-1233)GGG>GTG	p.G411V		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	411											0						GTCTTTGGGCCCACTGCTGCT	0.567													23	204					3.10358e-05	3.20041e-05	1	0	A	77817771	A	A	77817771	3	1	65	1	0	0	0	0	1	0	0	0	682	623	22	4	1153	4	ANKRD56	4	77817771	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	19974125	77817771	113336505	149	12980											
HNRPDL	9987	broad.mit.edu	37	chr4	83350506	83350506	+	Frame_Shift_Del	DEL	G	-	-																															tagtgacggagctgtcggcaGgggggtgctggcgcgcagtc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:83350506delG	uc003hmr.2	-	1	873	c.338delC	c.(337-339)CCTfs	p.P113fs	ENOPH1_uc003hmv.2_5'Flank|ENOPH1_uc003hmw.2_5'Flank|ENOPH1_uc003hmx.2_5'Flank|HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Frame_Shift_Del_p.P113fs	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	113					regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				GCTGTCGGCAGGGGGGTGCTG	0.597													---	---	---								-	83350506	-	-	83350506	7	5	65	1	0	1	0	1	0	0	0	0	7315	1000	35	0	952	0	HNRPDL	4	83350506	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	5532735	83350506	107803770	150	12981											
HERC6	55008	broad.mit.edu	37	chr4	89349789	89349789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caattctgcaaaaaaaggatGaatttcctccatcacccaga	16	9	5	11	0	2	2	1	1	1	1	4	3	4	3	3	1	1	1	3	1	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:89349789G>A	uc011cdi.1	+	16	2176	c.1993G>A	c.(1993-1995)GAA>AAA	p.E665K	HERC6_uc011cdj.1_Missense_Mutation_p.E629K|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	665					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		AAAAAAGGATGAATTTCCTCC	0.378													5	29					0	0	0	0	A	89349789	A	A	89349789	3	1	65	1	0	0	0	0	1	0	0	0	7101	1291	45	2	1852	2	HERC6	4	89349789	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	5999283	89349789	101804487	151	12982											
H2AFZ	3015	broad.mit.edu	37	chr4	100869668	100869668	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatcagagatttgtggatgTgtggaatgacacctaggaga	13	10	13	5	0	1	3	1	1	0	2	1	7	1	5	1	3	0	0	1	3	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:100869668T>C	uc003hvo.1	-	5	523	c.338A>G	c.(337-339)CAC>CGC	p.H113R	DNAJB14_uc003hvl.2_5'Flank|DNAJB14_uc010ili.2_5'Flank|DNAJB14_uc003hvm.2_5'Flank|H2AFZ_uc003hvn.1_3'UTR|LOC256880_uc003hvp.1_5'Flank	NM_002106	NP_002097	P0C0S5	H2AZ_HUMAN	H2A histone family, member Z	113					nucleosome assembly	nucleosome|nucleus	DNA binding				0				OV - Ovarian serous cystadenocarcinoma(123;2.32e-08)		TTTGTGGATGTGTGGAATGAC	0.368													12	117					0	0	0	0	C	100869668	C	C	100869668	3	2	65	1	0	0	0	0	1	0	0	0	6970	1696	59	5	52	5	H2AFZ	4	100869668	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	11519879	100869668	90284608	152	12983											
CENPE	1062	broad.mit.edu	37	chr4	104057410	104057410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgagaggtttgctttaactCtcattgaaagctctttttgg	8	17	10	6	0	2	2	1	2	2	1	3	3	2	2	0	2	3	3	0	2	2	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:104057410C>T	uc003hxb.1	-	40	6500	c.6410G>A	c.(6409-6411)AGA>AAA	p.R2137K	CENPE_uc003hxc.1_Missense_Mutation_p.R2016K	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	2137	Kinetochore-binding domain.|Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TGCTTTAACTCTCATTGAAAG	0.363													16	159					0	0	0	0	T	104057410	T	T	104057410	3	4	65	1	0	0	0	0	1	0	0	0	3245	913	32	2	1735	2	CENPE	4	104057410	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3187742	104057410	87096866	153	12984											
PDE5A	8654	broad.mit.edu	37	chr4	120442176	120442176	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgataggcaacattcttccGataattcttcttaacactta	13	15	4	9	1	3	1	0	1	3	0	4	2	4	1	1	1	2	1	1	1	5	8			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:120442176G>A	uc003idh.2	-	13	1974	c.1819C>T	c.(1819-1821)CGG>TGG	p.R607W	uc003ide.3_Intron|PDE5A_uc003idf.2_Missense_Mutation_p.R565W|PDE5A_uc003idg.2_Missense_Mutation_p.R555W|uc003idi.3_Intron	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	607	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	ACATTCTTCCGATAATTCTTC	0.299													14	245					0	0	0	0	A	120442176	A	A	120442176	3	1	65	1	0	0	0	0	1	0	0	0	11698	1057	37	1	844	1	PDE5A	4	120442176	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	16384766	120442176	70712100	154	12985											
FAT4	79633	broad.mit.edu	37	chr4	126336687	126336687	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggcacaaatggacaggttcGctatggcattgttaatggta	12	11	12	6	1	0	0	0	0	0	0	1	1	0	1	0	5	0	6	0	5	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:126336687G>A	uc003ifj.3	+	5	6569	c.6569G>A	c.(6568-6570)CGC>CAC	p.R2190H	FAT4_uc011cgp.1_Missense_Mutation_p.R488H	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2190	Cadherin 21.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGACAGGTTCGCTATGGCATT	0.413													15	178					0	0	0	0	A	126336687	A	A	126336687	3	1	65	1	0	0	0	0	1	0	0	0	5724	1087	38	1	6587	1	FAT4	4	126336687	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	5894511	126336687	64817589	155	12986											
LARP1B	55132	broad.mit.edu	37	chr4	129043274	129043274	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacttgctaaagttatcaaTgatggcttatactattatga	14	15	7	5	0	1	2	1	2	0	0	1	3	1	2	0	1	3	3	0	1	9	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:129043274T>C	uc003iga.2	+	11	1586	c.1455T>C	c.(1453-1455)AAT>AAC	p.N485N	LARP1B_uc003igc.2_5'UTR|LARP1B_uc003ifz.1_Silent_p.N485N|LARP1B_uc003igb.1_Silent_p.N200N	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	485							RNA binding				0						AAGTTATCAATGATGGCTTAT	0.403													20	154					0	0	0	0	C	129043274	C	C	129043274	2	2	65	1	0	0	0	0	0	0	0	1	8669	1461	51	5		5	LARP1B	4	129043274	Silent	SNP	T	TCGA-CN-5369-01A-01D-1434-08	2706587	129043274	62111002	156	12987											
LARP1B	55132	broad.mit.edu	37	chr4	129121769	129121769	+	Frame_Shift_Del	DEL	T	-	-																															agatcacttcaataaaaaaaTgtatgaggaatttagacaac																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:129121769delT	uc003iga.2	+	17	2389	c.2258delT	c.(2257-2259)ATGfs	p.M753fs	LARP1B_uc003igc.2_Frame_Shift_Del_p.M172fs|LARP1B_uc010ioa.1_RNA|LARP1B_uc003ige.2_RNA|LARP1B_uc003igd.2_RNA|LARP1B_uc003igf.2_5'UTR	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	753							RNA binding				0						AATAAAAAAATGTATGAGGAA	0.343													---	---	---								-	129121769	-	-	129121769	7	5	65	1	0	1	0	1	0	0	0	0	8669	1464	51	0	2450	0	LARP1B	4	129121769	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	78495	129121769	62032507	157	12988											
MAML3	55534	broad.mit.edu	37	chr4	140641384	140641384	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggttctgggagggtcctattCccatcatgcctgcgttctgt	4	14	12	11	1	3	0	1	0	2	0	5	1	5	1	3	3	2	2	3	3	1	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:140641384C>G	uc003ihz.1	-	7	3247	c.2495G>C	c.(2494-2496)GGA>GCA	p.G832A	MGST2_uc010ioi.1_Intron|MAML3_uc011chd.1_Missense_Mutation_p.G300A	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	833	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					GGGTCCTATTCCCATCATGCC	0.607													14	277					0	0	0	0	G	140641384	G	G	140641384	3	3	65	1	0	0	0	0	1	0	0	0	9260	855	30	2	910	2	MAML3	4	140641384	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	11519615	140641384	50512892	158	12989											
SMARCA5	8467	broad.mit.edu	37	chr4	144459762	144459762	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttcacgagtactaatcttCagtcaaatgacaagggtatt	13	12	9	7	1	4	1	3	1	1	0	4	2	4	1	0	2	1	3	0	2	5	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:144459762C>T	uc003ijg.2	+	12	1977	c.1515C>T	c.(1513-1515)TTC>TTT	p.F505F		NM_003601	NP_003592	O60264	SMCA5_HUMAN	SWI/SNF-related matrix-associated	505	Helicase C-terminal.				CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)					TACTAATCTTCAGTCAAATGA	0.373													18	198					0	0	0	0	T	144459762	T	T	144459762	2	4	65	1	0	0	0	0	0	0	0	1	14835	825	29	2		2	SMARCA5	4	144459762	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3818378	144459762	46694514	159	12990											
KIAA0922	23240	broad.mit.edu	37	chr4	154517420	154517420	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taatttgcagggtacgcattCtgaggaatccaggtttggca	10	12	12	7	1	1	1	0	1	1	0	2	2	2	2	1	4	2	5	1	4	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:154517420C>T	uc003inm.3	+	20	2055	c.2003C>T	c.(2002-2004)TCT>TTT	p.S668F	KIAA0922_uc010ipp.2_Missense_Mutation_p.S669F|KIAA0922_uc010ipq.2_Missense_Mutation_p.S437F	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	668	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				GGTACGCATTCTGAGGAATCC	0.418													18	232					0	0	0	0	T	154517420	T	T	154517420	3	4	65	1	0	0	0	0	1	0	0	0	8240	913	32	2	2084	2	KIAA0922	4	154517420	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	10057658	154517420	36636856	160	12991											
DCHS2	54798	broad.mit.edu	37	chr4	155157144	155157144	+	Frame_Shift_Del	DEL	A	-	-																															tattcttttctgggagggtgAaaaaatactgatcttgagtg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:155157144delA	uc003inw.2	-	25	7295	c.7295delT	c.(7294-7296)TTCfs	p.F2432fs		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2432	Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGGAGGGTGAAAAAATACTG	0.438													---	---	---								-	155157144	-	-	155157144	7	5	65	1	0	1	0	1	0	0	0	0	4305	246	9	0	1459	0	DCHS2	4	155157144	Frame_Shift_Del	DEL	A	TCGA-CN-5369-01A-01D-1434-08	639724	155157144	35997132	161	12992											
TKTL2	84076	broad.mit.edu	37	chr4	164394865	164394865	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgcacggtcttcacgtcggGcttggcgtcgttggccatca	4	11	13	13	5	3	0	2	0	1	0	5	0	3	0	1	4	1	3	1	4	0	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:164394865G>A	uc003iqp.3	-	1	183	c.22C>T	c.(22-24)CCC>TCC	p.P8S		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	8						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TTCACGTCGGGCTTGGCGTCG	0.637													6	38					0	0	0	0	A	164394865	A	A	164394865	3	1	65	1	0	0	0	0	1	0	0	0	16002	1203	42	4	1862	4	TKTL2	4	164394865	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	9237721	164394865	26759411	162	12993											
VEGFC	7424	broad.mit.edu	37	chr4	177650751	177650751	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctcttctgtccttgagttGaggttggcctgttctctgtt	2	19	11	9	0	3	2	0	2	3	0	6	2	4	2	2	2	0	4	2	2	0	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:177650751G>C	uc003ius.1	-	2	727	c.297C>G	c.(295-297)CTC>CTG	p.L99L		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	99					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		TCCTTGAGTTGAGGTTGGCCT	0.373													7	122					0	0	0	0	C	177650751	C	C	177650751	2	2	65	1	0	0	0	0	0	0	0	1	17220	1277	45	2		2	VEGFC	4	177650751	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	13255886	177650751	13503525	163	12994											
STOX2	56977	broad.mit.edu	37	chr4	184930441	184930441	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatttcataactccttccctCataagaactaacagtaaatg	15	13	3	10	0	2	1	2	0	0	1	4	1	4	1	2	0	3	1	2	0	7	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:184930441C>G	uc003ivz.1	+	3	1885	c.450C>G	c.(448-450)CTC>CTG	p.L150L	STOX2_uc003iwa.1_5'UTR	NM_020225	NP_064610	Q9P2F5	STOX2_HUMAN	storkhead box 2	150					embryo development|maternal placenta development						0		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		CTCCTTCCCTCATAAGAACTA	0.532													10	68					0	0	0	0	G	184930441	G	G	184930441	2	3	65	1	0	0	0	0	0	0	0	1	15386	813	29	2		2	STOX2	4	184930441	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	7279690	184930441	6223835	164	12995											
PDLIM3	27295	broad.mit.edu	37	chr4	186425655	186425655	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccactcccacatttgtcacaGagcggcatcctctgtgcccc	7	9	7	18	1	2	1	1	0	1	1	4	1	4	1	5	1	2	1	5	1	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:186425655G>A	uc003ixw.3	-	7	1003	c.879C>T	c.(877-879)CTC>CTT	p.L293L	PDLIM3_uc003ixx.3_Silent_p.L245L|PDLIM3_uc010isi.2_RNA	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	293	LIM zinc-binding.					sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		ATTTGTCACAGAGCGGCATCC	0.502													5	59					0	0	0	0	A	186425655	A	A	186425655	2	1	65	1	0	0	0	0	0	0	0	1	11735	929	33	2		2	PDLIM3	4	186425655	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1495214	186425655	4728621	165	12996											
FAT1	2195	broad.mit.edu	37	chr4	187517815	187517815	+	Frame_Shift_Del	DEL	G	-	-																															gccactgcttttcggtgcccGtgcacagactcggggttaaa																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr4:187517815delG	uc003izf.2	-	25	13067	c.12879delC	c.(12877-12879)CACfs	p.H4293fs	FAT1_uc010isn.2_5'Flank|FAT1_uc003ize.2_Frame_Shift_Del_p.H184fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4293	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTCGGTGCCCGTGCACAGACT	0.552										HNSCC(5;0.00058)			---	---	---								-	187517815	-	-	187517815	7	5	65	1	0	1	0	1	0	0	0	0	5721	1136	40	0	899	0	FAT1	4	187517815	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	1092160	187517815	3636461	166	12997											
MTRR	4552	broad.mit.edu	37	chr5	7875406	7875406	+	Frame_Shift_Del	DEL	G	-	-																															aatacacctacttttgcaatGgggggaagataattgataaa																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:7875406delG	uc003jed.2	+	4	430	c.400delG	c.(400-402)GGGfs	p.G134fs	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Frame_Shift_Del_p.G107fs|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	134	FMN (By similarity).|Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CTTTTGCAATGGGGGGAAGAT	0.408													---	---	---								-	7875406	-	-	7875406	7	5	65	1	0	1	0	1	0	0	0	0	10014	1348	47	0	414	0	MTRR	5	7875406	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08		7875406	173039854	167	12998											
MARCH6	10299	broad.mit.edu	37	chr5	10405790	10405790	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaagatttattttgtcagtgGtaagaagatgtttccattgt	11	17	10	3	0	1	3	1	0	0	3	2	4	2	3	1	1	0	2	1	1	4	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:10405790G>A	uc003jet.1	+	16	1635	c.1452_splice	c.e16+1	p.V484_splice	MARCH6_uc011cmu.1_Splice_Site_p.V436_splice|MARCH6_uc003jeu.1_Splice_Site_p.V182_splice|MARCH6_uc011cmv.1_Splice_Site_p.V379_splice	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6						protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						TTTGTCAGTGGTAAGAAGATG	0.328													6	99					0	0	0	0	A	10405790	A	A	10405790	5	1	65	1	0	0	0	0	0	0	1	0	9358	1275	44	4	1515	4	MARCH6	5	10405790	Splice_Site	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2530384	10405790	170509470	168	12999											
MYO10	4651	broad.mit.edu	37	chr5	16694554	16694554	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagtacatcagcttggactgGcggaggacaaaccagcgctt	12	7	12	10	2	1	0	1	0	0	0	1	3	1	3	1	4	4	3	1	4	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:16694554G>A	uc003jft.3	-	27	4194	c.3726C>T	c.(3724-3726)CGC>CGT	p.R1242R	MYO10_uc011cnc.1_Silent_p.R121R|MYO10_uc011cnd.1_Silent_p.R599R|MYO10_uc011cne.1_Silent_p.R599R|MYO10_uc010itx.2_Silent_p.R865R	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1242	PH 1.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						GCTTGGACTGGCGGAGGACAA	0.572													21	195					0	0	0	0	A	16694554	A	A	16694554	2	1	65	1	0	0	0	0	0	0	0	1	10115	1190	42	4		4	MYO10	5	16694554	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6288764	16694554	164220706	169	13000											
CDH9	1007	broad.mit.edu	37	chr5	26906877	26906877	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtccttgcaatatgctataGaccactttggcactatttcc	9	15	6	11	0	0	1	0	0	0	1	2	1	2	1	3	1	2	3	3	1	5	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:26906877G>C	uc003jgs.1	-	4	763	c.594C>G	c.(592-594)GTC>GTG	p.V198V	CDH9_uc010iug.2_Silent_p.V198V	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	198	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATATGCTATAGACCACTTTGG	0.398													9	80					0	0	0	0	C	26906877	C	C	26906877	2	2	65	1	0	0	0	0	0	0	0	1	3132	929	33	2		2	CDH9	5	26906877	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	10212323	26906877	154008383	170	13001											
EGFLAM	133584	broad.mit.edu	37	chr5	38427202	38427202	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccagcattacctttccttCatggaatttgagatcacatt	10	14	5	12	0	2	1	2	1	0	1	3	3	3	2	4	1	2	1	4	1	2	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:38427202C>T	uc003jlc.1	+	14	2226	c.1902C>T	c.(1900-1902)TTC>TTT	p.F634F	EGFLAM_uc003jlb.1_Silent_p.F634F|EGFLAM_uc003jle.1_Silent_p.F400F|EGFLAM_uc003jlf.1_5'UTR	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	634	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					ACCTTTCCTTCATGGAATTTG	0.493													25	193					0	0	0	0	T	38427202	T	T	38427202	2	4	65	1	0	0	0	0	0	0	0	1	4988	825	29	2		2	EGFLAM	5	38427202	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	11520325	38427202	142488058	171	13002											
HEATR7B2	133558	broad.mit.edu	37	chr5	41019061	41019061	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggaaggggcagcagcctcCgaatattctcctcaagaatg	11	8	12	10	1	2	1	1	0	1	1	4	3	3	2	3	3	2	2	3	3	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:41019061C>T	uc003jmj.3	-	25	2991	c.2501G>A	c.(2500-2502)CGG>CAG	p.R834Q	HEATR7B2_uc003jmi.3_Missense_Mutation_p.R389Q	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	834							binding			ovary(6)|central_nervous_system(2)	8						CAGCAGCCTCCGAATATTCTC	0.458													9	47					0	0	0	0	T	41019061	T	T	41019061	3	4	65	1	0	0	0	0	1	0	0	0	7074	652	23	1	2328	1	HEATR7B2	5	41019061	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2591859	41019061	139896199	172	13003											
HCN1	348980	broad.mit.edu	37	chr5	45262736	45262736	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catgcgggaggtcggggtcgTagtagacgatgtggaattca	9	9	17	6	4	1	1	1	0	0	1	3	4	1	3	0	5	1	2	0	5	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:45262736T>C	uc003jok.2	-	8	1985	c.1960A>G	c.(1960-1962)ACG>GCG	p.T654A		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	654	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GTCGGGGTCGTAGTAGACGAT	0.537													21	146					0	0	0	0	C	45262736	C	C	45262736	3	2	65	1	0	0	0	0	1	0	0	0	7035	1638	57	5	716	5	HCN1	5	45262736	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	4243675	45262736	135652524	173	13004											
VCAN	1462	broad.mit.edu	37	chr5	82843897	82843897	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttatgttggtgcactttgtGagcaaggtaagagctattgc	9	14	13	5	0	0	2	0	1	0	1	0	2	0	2	0	2	4	6	0	2	4	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:82843897G>A	uc003kii.3	+	10	9843	c.9487G>A	c.(9487-9489)GAG>AAG	p.E3163K	VCAN_uc003kij.3_Missense_Mutation_p.E2176K|VCAN_uc010jau.2_Missense_Mutation_p.E1409K|VCAN_uc003kik.3_Missense_Mutation_p.E422K|VCAN_uc003kil.3_Missense_Mutation_p.E1827K	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	3163	EGF-like 2; calcium-binding (Potential).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TGCACTTTGTGAGCAAGGTAA	0.388													10	110					0	0	0	0	A	82843897	A	A	82843897	3	1	65	1	0	0	0	0	1	0	0	0	17206	1291	45	2	9521	2	VCAN	5	82843897	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	37581161	82843897	98071363	174	13005											
FBN2	2201	broad.mit.edu	37	chr5	127670419	127670419	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttgaaacctacctgtacatCctgtggtccccttcttcact	7	14	5	15	0	2	1	1	1	1	0	4	1	4	1	5	1	3	1	5	1	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:127670419C>T	uc003kuu.2	-	31	4530	c.4091G>A	c.(4090-4092)GGA>GAA	p.G1364E	FBN2_uc003kuv.2_Missense_Mutation_p.G1331E	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1364	EGF-like 21; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ACCTGTACATCCTGTGGTCCC	0.428													9	162					0	0	0	0	T	127670419	T	T	127670419	3	4	65	1	0	0	0	0	1	0	0	0	5735	855	30	2	4787	2	FBN2	5	127670419	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	44826522	127670419	53244841	175	13006											
RAPGEF6	51735	broad.mit.edu	37	chr5	130782325	130782325	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattaagcagagagctgcggCgtgccctttttttgtgagca	8	12	12	9	2	0	2	0	1	0	1	0	3	0	2	1	1	5	3	1	1	1	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:130782325C>T	uc003kvn.1	-	22	3478	c.3272G>A	c.(3271-3273)CGC>CAC	p.R1091H	RAPGEF6_uc003kvp.1_Missense_Mutation_p.R1141H|RAPGEF6_uc003kvo.1_Missense_Mutation_p.R1104H|RAPGEF6_uc010jdi.1_Missense_Mutation_p.R1099H|RAPGEF6_uc010jdj.1_Missense_Mutation_p.R1099H|RAPGEF6_uc003kvq.2_Missense_Mutation_p.R816H|RAPGEF6_uc003kvr.2_Missense_Mutation_p.R1091H|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc003kvm.1_Missense_Mutation_p.R14H	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	1091					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		AGAGCTGCGGCGTGCCCTTTT	0.453													31	270					0	0	0	0	T	130782325	T	T	130782325	3	4	65	1	0	0	0	0	1	0	0	0	13113	768	27	1	1996	1	RAPGEF6	5	130782325	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3111906	130782325	50132935	176	13007											
PCDHA12	56137	broad.mit.edu	37	chr5	140256838	140256838	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccacgtggtggcgaaagTgcgcgcggtggacgctgact	6	6	19	10	6	0	1	0	1	0	0	0	3	0	2	1	5	1	1	1	5	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:140256838T>C	uc003lic.2	+	1	1908	c.1781T>C	c.(1780-1782)GTG>GCG	p.V594A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.V594A	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	594	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGCGAAAGTGCGCGCGGTG	0.692													10	92					0	0	0	0	C	140256838	C	C	140256838	3	2	65	1	0	0	0	0	1	0	0	0	11576	1696	59	5	1783	5	PCDHA12	5	140256838	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	9474513	140256838	40658422	177	13008											
PCDHB14	56122	broad.mit.edu	37	chr5	140604569	140604569	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccgccccaggaccggcacCtgcccctcgcctccttggtc	3	7	10	21	3	0	0	0	0	0	0	3	1	1	1	9	3	2	1	9	3	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:140604569C>A	uc003ljb.2	+	1	1492	c.1492C>A	c.(1492-1494)CTG>ATG	p.L498M	PCDHB14_uc011dal.1_Missense_Mutation_p.L345M	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	498	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACCGGCACCTGCCCCTCGC	0.652													25	162					7.33532e-06	7.62679e-06	1	0	A	140604569	A	A	140604569	3	1	65	1	0	0	0	0	1	0	0	0	11593	680	24	4	1494	4	PCDHB14	5	140604569	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	347731	140604569	40310691	178	13009											
PCDHGB1	56104	broad.mit.edu	37	chr5	140731194	140731194	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggcctcctatgtggtccAcgtgtctgagaacaacccac	9	9	9	14	1	2	1	1	1	1	1	4	2	4	1	4	2	2	0	4	2	3	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:140731194A>G	uc003ljo.1	+	1	1367	c.1367A>G	c.(1366-1368)CAC>CGC	p.H456R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.H456R	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	456	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATGTGGTCCACGTGTCTGAG	0.562													6	68					0	0	0	0	G	140731194	G	G	140731194	3	3	65	1	0	0	0	0	1	0	0	0	11616	159	6	5	1369	5	PCDHGB1	5	140731194	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	126625	140731194	40184066	179	13010											
PCDHGA5	56110	broad.mit.edu	37	chr5	140744135	140744135	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctttttgccctgaacccgCgaagcggcagcttggtcacc	7	9	11	14	3	1	1	1	1	0	0	1	2	1	1	3	2	5	3	3	2	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:140744135C>T	uc003lju.1	+	1	238	c.238C>T	c.(238-240)CGA>TGA	p.R80*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Nonsense_Mutation_p.R80*	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	80	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGAACCCGCGAAGCGGCAG	0.607													13	115					0	0	0	0	T	140744135	T	T	140744135	4	4	65	1	0	0	0	0	0	1	0	0	11611	760	27	1	240	1	PCDHGA5	5	140744135	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	12941	140744135	40171125	180	13011											
DIAPH1	1729	broad.mit.edu	37	chr5	140962827	140962827	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	taagaatgtccaataaggagGccaagccttcagcaccaaat	16	7	8	10	0	1	1	1	0	0	1	2	2	2	2	4	2	2	1	4	2	6	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:140962827G>A	uc003llb.3	-	6	707	c.566C>T	c.(565-567)GCC>GTC	p.A189V	DIAPH1_uc003llc.3_Missense_Mutation_p.A180V	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	189	GBD/FH3.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATAAGGAGGCCAAGCCTTC	0.413													14	295					0	0	0	0	A	140962827	A	A	140962827	3	1	65	1	0	0	0	0	1	0	0	0	4540	1203	42	4	3344	4	DIAPH1	5	140962827	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	218692	140962827	39952433	181	13012											
CPEB4	80315	broad.mit.edu	37	chr5	173380196	173380196	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaaggagctgggagagttgCgttctctaatcaacagagtt	13	10	12	6	1	2	2	1	0	1	2	3	4	2	3	0	2	3	4	0	2	4	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:173380196C>T	uc003mcs.3	+	9	3289	c.1883C>T	c.(1882-1884)GCG>GTG	p.A628V	CPEB4_uc010jju.1_Missense_Mutation_p.A603V|CPEB4_uc010jjv.2_Missense_Mutation_p.A611V|CPEB4_uc011dfg.1_Missense_Mutation_p.A603V|CPEB4_uc003mct.3_Missense_Mutation_p.A238V|CPEB4_uc003mcu.3_Missense_Mutation_p.A221V	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	628	RRM 2.						nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GGGAGAGTTGCGTTCTCTAAT	0.463													18	206					0	0	0	0	T	173380196	T	T	173380196	3	4	65	1	0	0	0	0	1	0	0	0	3818	768	27	1	1917	1	CPEB4	5	173380196	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	32417369	173380196	7535064	182	13013											
GNB2L1	10399	broad.mit.edu	37	chr5	180666085	180666085	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accttgcctccagaagcacaGagggatccatctggagagac	12	6	11	12	0	1	3	0	0	1	3	3	6	3	5	4	2	2	1	4	2	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr5:180666085G>A	uc003mni.1	-	5	724	c.618C>T	c.(616-618)CTC>CTT	p.L206L	GNB2L1_uc003mnh.1_Silent_p.L165L|GNB2L1_uc003mnk.1_Silent_p.L128L|GNB2L1_uc003mnj.1_Silent_p.L160L|GNB2L1_uc003mnl.1_5'UTR|GNB2L1_uc011dhk.1_Silent_p.L206L|GNB2L1_uc010jls.2_3'UTR	NM_006098	NP_006089	P63244	GBLP_HUMAN	guanine nucleotide binding protein (G protein),	206	WD 5.				apoptosis|cell cycle|gastrulation|interspecies interaction between organisms|negative regulation of cell growth|negative regulation of phagocytosis|negative regulation of translation|negative regulation of Wnt receptor signaling pathway|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of gastrulation|positive regulation of GTPase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein homooligomerization|positive regulation of protein phosphorylation|regulation of cell cycle|regulation of cell division|regulation of establishment of cell polarity|regulation of protein localization|rhythmic process	cytoskeleton|dendrite|midbody|nucleus|perikaryon|perinuclear region of cytoplasm|phagocytic cup|small ribosomal subunit	ion channel inhibitor activity|protein kinase C binding|protein phosphatase binding|protein tyrosine kinase inhibitor activity|receptor tyrosine kinase binding|SH2 domain binding				0	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.101)|all cancers(165;0.11)		CAGAAGCACAGAGGGATCCAT	0.517													15	260					0	0	0	0	A	180666085	A	A	180666085	2	1	65	1	0	0	0	0	0	0	0	1	6555	929	33	2		2	GNB2L1	5	180666085	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	7285889	180666085	249175	183	13014											
DSP	1832	broad.mit.edu	37	chr6	7574448	7574448	+	Missense_Mutation	SNP	G	A	A																															ttggactatttcagaaactgGaaaatatcaatggtgttaca																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:7574448G>A	uc003mxp.1	+	16	2539	c.2260G>A	c.(2260-2262)GAA>AAA	p.E754K	DSP_uc003mxq.1_Missense_Mutation_p.E754K	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	754	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TCAGAAACTGGAAAATATCAA	0.353													9	151					0	0	0	0	A	7574448	A	A	7574448	3	1	65	1	0	0	0	0	1	0	0	0	4803	1175	41	2	2322	2	DSP	6	7574448	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08		7574448	163540619	184	13015	28	2									
DSP	1832	broad.mit.edu	37	chr6	7574454	7574454	+	Missense_Mutation	SNP	A	T	T																															tatttcagaaactggaaaatAtcaatggtgttacagatggc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:7574454A>T	uc003mxp.1	+	16	2545	c.2266A>T	c.(2266-2268)ATC>TTC	p.I756F	DSP_uc003mxq.1_Missense_Mutation_p.I756F	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	756	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACTGGAAAATATCAATGGTGT	0.348													8	154					0	0	0	0	T	7574454	T	T	7574454	3	4	65	1	0	0	0	0	1	0	0	0	4803	449	16	5	2328	5	DSP	6	7574454	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	6	7574454	163540613	185	13016	28	2									
TFAP2A	7020	broad.mit.edu	37	chr6	10404781	10404781	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagcgacgcgttgagacactCgggtggtgagagccgccgct	7	6	16	12	6	0	2	0	2	0	2	1	5	0	2	2	2	2	2	2	2	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:10404781C>G	uc003myr.2	-	4	976	c.724G>C	c.(724-726)GAG>CAG	p.E242Q	TFAP2A_uc003myq.2_Missense_Mutation_p.E236Q|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Missense_Mutation_p.E242Q|TFAP2A_uc003myt.2_Missense_Mutation_p.E238Q|TFAP2A_uc003myu.1_Missense_Mutation_p.E242Q	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	242					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				TTGAGACACTCGGGTGGTGAG	0.507													5	24					0	0	0	0	G	10404781	G	G	10404781	3	3	65	1	0	0	0	0	1	0	0	0	15853	893	31	3	605	3	TFAP2A	6	10404781	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2830327	10404781	160710286	186	13017											
SLC17A4	10050	broad.mit.edu	37	chr6	25762243	25762243	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gggggacatttccagtgatgGcaatttaaacgtggctcaag	11	10	13	7	1	1	1	1	1	0	0	2	2	2	2	1	4	1	2	1	4	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:25762243G>A	uc003nfe.2	+	2	172	c.53G>A	c.(52-54)GGC>GAC	p.G18D	SLC17A4_uc011djx.1_Missense_Mutation_p.G18D|SLC17A4_uc003nff.1_5'UTR|SLC17A4_uc003nfg.2_5'UTR	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	18					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						TCCAGTGATGGCAATTTAAAC	0.418													10	80					0	0	0	0	A	25762243	A	A	25762243	3	1	65	1	0	0	0	0	1	0	0	0	14484	1203	42	4	55	4	SLC17A4	6	25762243	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	15357462	25762243	145352824	187	13018											
HIST1H2AC	8334	broad.mit.edu	37	chr6	26124494	26124494	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtaagcaaggaggcaaagctCgcgccaaagcgaaatcccgc	14	3	12	12	4	0	0	0	0	0	0	2	2	1	1	2	2	3	4	2	2	5	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:26124494C>T	uc003ngm.2	+	1	122	c.34C>T	c.(34-36)CGC>TGC	p.R12C	HIST1H2BC_uc003ngk.3_5'Flank|HIST1H2BC_uc003ngl.2_5'Flank|HIST1H2AC_uc003ngn.2_RNA|HIST1H2AC_uc003ngo.2_RNA|HIST1H2AC_uc003ngp.2_Missense_Mutation_p.R12C	NM_003512	NP_003503	Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	12					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGGCAAAGCTCGCGCCAAAGC	0.542													6	58					0	0	0	0	T	26124494	T	T	26124494	3	4	65	1	0	0	0	0	1	0	0	0	7169	884	31	1	36	1	HIST1H2AC	6	26124494	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	362251	26124494	144990573	188	13019											
ZNF311	282890	broad.mit.edu	37	chr6	28962832	28962832	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagaaacagtcactggagaGagggatttcctactcccatc	12	9	10	10	0	1	2	1	1	0	2	4	6	3	4	2	2	2	0	2	2	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:28962832G>A	uc003nlu.2	-	7	2460	c.1947C>T	c.(1945-1947)CTC>CTT	p.L649L	ZNF311_uc011dlk.1_Silent_p.L557L|ZNF311_uc003nlv.2_Silent_p.L557L	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	649					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						TCACTGGAGAGAGGGATTTCC	0.358													11	100					0	0	0	0	A	28962832	A	A	28962832	2	1	65	1	0	0	0	0	0	0	0	1	17901	929	33	2		2	ZNF311	6	28962832	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2838338	28962832	142152235	189	13020											
OR2J2	26707	broad.mit.edu	37	chr6	29141556	29141556	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggaaacctgttcatcatcatCctgtcatacgtggactccca	10	11	7	13	1	4	0	4	0	0	0	6	2	6	2	3	2	2	1	3	2	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:29141556C>G	uc011dlm.1	+	1	246	c.144C>G	c.(142-144)ATC>ATG	p.I48M		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	48	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCATCATCATCCTGTCATACG	0.443													26	363					0	0	0	0	G	29141556	G	G	29141556	3	3	65	1	0	0	0	0	1	0	0	0	11057	845	30	2	146	2	OR2J2	6	29141556	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	178724	29141556	141973511	190	13021											
TRIM10	10107	broad.mit.edu	37	chr6	30122127	30122127	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgatgccagtgtgggcCagaacacaggtggcccggtc	7	7	15	12	1	0	2	0	1	0	1	1	2	0	2	4	4	2	0	4	4	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:30122127C>A	uc003npo.3	-	7	1141	c.1065G>T	c.(1063-1065)CTG>CTT	p.L355L	TRIM10_uc003npn.2_Silent_p.L355L	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	355	B30.2/SPRY.					cytoplasm	zinc ion binding				0						CAGTGTGGGCCAGAACACAGG	0.612													5	72					0.000602214	0.000613946	1	0	A	30122127	A	A	30122127	2	1	65	1	0	0	0	0	0	0	0	1	16553	581	21	4		4	TRIM10	6	30122127	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	980571	30122127	140992940	191	13022											
HLA-C	3107	broad.mit.edu	37	chr6	31238116	31238116	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atctcctgctggcctggtctCcacaagctcggtgtcctggg	4	11	12	14	1	2	0	0	0	2	0	6	0	3	0	4	4	2	2	4	4	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:31238116C>A	uc003nsy.2	-	4	773	c.766G>T	c.(766-768)GAG>TAG	p.E256*	HLA-C_uc011dnj.1_Nonsense_Mutation_p.E228*|HLA-C_uc003nsx.2_Nonsense_Mutation_p.E135*|HLA-C_uc003nsz.2_Nonsense_Mutation_p.E256*|HLA-C_uc010jsl.2_Nonsense_Mutation_p.E256*|HLA-C_uc003nta.2_Nonsense_Mutation_p.E256*|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_Nonsense_Mutation_p.E135*	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	256	Extracellular (Potential).|Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						GGCCTGGTCTCCACAAGCTCG	0.627													9	114					0.00448238	0.00452562	1	0	A	31238116	A	A	31238116	4	1	65	1	0	0	0	0	0	1	0	0	7236	864	30	2	354	2	HLA-C	6	31238116	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1115989	31238116	139876951	192	13023											
HLA-C	3107	broad.mit.edu	37	chr6	31238162	31238162	+	Frame_Shift_Del	DEL	G	-	-																															tcctccccatcccgctgccaGgtcagtgtgatctccgcagg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:31238162delG	uc003nsy.2	-	4	727	c.720delC	c.(718-720)ACCfs	p.T240fs	HLA-C_uc011dnj.1_Frame_Shift_Del_p.T212fs|HLA-C_uc003nsx.2_Frame_Shift_Del_p.T119fs|HLA-C_uc003nsz.2_Frame_Shift_Del_p.T240fs|HLA-C_uc010jsl.2_Frame_Shift_Del_p.T240fs|HLA-C_uc003nta.2_Frame_Shift_Del_p.T240fs|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_Frame_Shift_Del_p.T119fs	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	240	Extracellular (Potential).|Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						CCCGCTGCCAGGTCAGTGTGA	0.637													---	---	---								-	31238162	-	-	31238162	7	5	65	1	0	1	0	1	0	0	0	0	7236	987	35	0	400	0	HLA-C	6	31238162	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	46	31238162	139876905	193	13024											
CFB	629	broad.mit.edu	37	chr6	31912678	31912679	+	5'Flank	DEL	TC	-	-																															caaggggaaggccacctgtgTctctgtggccagcatgcatg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:31912678_31912679delTC	uc003nyj.3	+						C2_uc011doo.1_Intron|C2_uc011dop.1_Intron|C2_uc003nyf.2_Intron|C2_uc010jtk.2_Intron|C2_uc011doq.1_Intron|C2_uc003nyg.2_Intron|CFB_uc011dor.1_Intron|C2_uc003nyh.1_Intron|CFB_uc011dos.1_5'Flank|CFB_uc003nyi.2_5'Flank	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein						complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						GCCACCTGTGTCTCTGTGGCCA	0.579													---	---	---								-	31912679	-	-	31912678	6	5	65	0	1	1	0	1	0	0	0	0	3293	1682	58	0		0	CFB	6	31912678	5'Flank	DEL	TC	TCGA-CN-5369-01A-01D-1434-08	674516	31912678	139202389	194	13025											
ZBTB22	9278	broad.mit.edu	37	chr6	33283004	33283005	+	Frame_Shift_Del	DEL	CA	-	-																															gcccaggcggtgccggcgctCacagtgtcctcggtggcgca																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:33283004_33283005delCA	uc003oeb.2	-	2	1841_1842	c.1689_1690delTG	c.(1687-1692)TGTGAGfs	p.C563fs	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Frame_Shift_Del_p.C563fs	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	563_564					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGCCGGCGCTCACAGTGTCCTC	0.663													---	---	---								-	33283005	-	-	33283004	7	5	65	1	0	1	0	1	0	0	0	0	17597	835	29	0	218	0	ZBTB22	6	33283004	Frame_Shift_Del	DEL	CA	TCGA-CN-5369-01A-01D-1434-08	1370326	33283004	137832063	195	13026											
ANKS1A	23294	broad.mit.edu	37	chr6	34951143	34951143	+	Frame_Shift_Del	DEL	C	-	-																															tacaaaagaagtagataaaaCccccccaccccagccacctc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:34951143delC	uc003ojx.3	+	7	1095	c.953delC	c.(952-954)ACCfs	p.T318fs	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_5'UTR|ANKS1A_uc010jvp.1_5'UTR	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	318						cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						GTAGATAAAACCCCCCCACCC	0.418													---	---	---								-	34951143	-	-	34951143	7	5	65	1	0	1	0	1	0	0	0	0	688	507	18	0	979	0	ANKS1A	6	34951143	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	1668139	34951143	136163924	196	13027											
RUNX2	860	broad.mit.edu	37	chr6	45390398	45390398	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcaaaatgagcgacgtgAgcccggtggtggctgcgcaa	9	5	16	11	5	0	2	0	2	0	0	0	3	0	2	2	4	3	3	2	4	3	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:45390398A>G	uc011dvx.1	+	3	337	c.127A>G	c.(127-129)AGC>GGC	p.S43G	RUNX2_uc011dvy.1_Missense_Mutation_p.S43G|RUNX2_uc003oxt.2_Missense_Mutation_p.S29G	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	43					negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						GAGCGACGTGAGCCCGGTGGT	0.378													8	49					0	0	0	0	G	45390398	G	G	45390398	3	3	65	1	0	0	0	0	1	0	0	0	13813	304	11	5	149	5	RUNX2	6	45390398	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	10439255	45390398	125724669	197	13028											
EFHC1	114327	broad.mit.edu	37	chr6	52318995	52318995	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggatgatacggtggaaattCgagaggtccacgaacggaat	13	8	14	6	4	0	2	0	1	0	1	2	7	1	5	1	5	2	0	1	5	4	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:52318995C>T	uc003pap.3	+	5	1041	c.826C>T	c.(826-828)CGA>TGA	p.R276*	EFHC1_uc011dwv.1_Nonsense_Mutation_p.R185*|EFHC1_uc011dww.1_Nonsense_Mutation_p.R257*	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	276	DM10 2.					axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					GGTGGAAATTCGAGAGGTCCA	0.448													18	163					0	0	0	0	T	52318995	T	T	52318995	4	4	65	1	0	0	0	0	0	1	0	0	4968	876	31	1	854	1	EFHC1	6	52318995	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6928597	52318995	118796072	198	13029											
KHDRBS2	202559	broad.mit.edu	37	chr6	62995847	62995848	+	Missense_Mutation	DNP	CT	GG	GG																															ctcaggcaaatatttctcctCttccatagcgcggacttcgg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:62995847_62995848CT>GG	uc003peg.2	-	1	253_254	c.6_7AG>CC	c.(4-9)GAAGAG>GACCAG	p.2_3EE>DQ		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	2_3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TATTTCTCCTCTTCCATAGCGC	0.609													4	33					0	0	0	0	GG	62995848	GG	GG	62995847	3	3	65	1	0	0	0	0	1	0	0	0	8186	922	32	2	1078	2	KHDRBS2	6	62995847	Missense_Mutation	DNP	CT	TCGA-CN-5369-01A-01D-1434-08	10676852	62995847	108119220	199	13030											
CD109	135228	broad.mit.edu	37	chr6	74520797	74520797	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatatccaagtgaccgtgaCggggcctagctcaccaagtc	12	7	10	12	2	1	2	1	2	0	0	3	2	2	2	4	2	1	1	4	2	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:74520797C>T	uc003php.2	+	28	4054	c.3629C>T	c.(3628-3630)ACG>ATG	p.T1210M	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Missense_Mutation_p.T1210M|CD109_uc010kba.2_Missense_Mutation_p.T1133M	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	1210						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						GTGACCGTGACGGGGCCTAGC	0.458													18	133					0	0	0	0	T	74520797	T	T	74520797	3	4	65	1	0	0	0	0	1	0	0	0	2978	536	19	1	3739	1	CD109	6	74520797	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	11524950	74520797	96594270	200	13031											
HTR1B	3351	broad.mit.edu	37	chr6	78173080	78173080	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacccaggtctcggagcccGcgggcggcggtggagcgcac	6	3	18	14	6	1	0	0	0	1	0	2	3	1	2	2	6	3	1	2	6	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:78173080G>A	uc003pil.1	-	1	41	c.41C>T	c.(40-42)GCG>GTG	p.A14V		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	14	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	CTCGGAGCCCGCGGGCGGCGG	0.642													10	130					0	0	0	0	A	78173080	A	A	78173080	3	1	65	1	0	0	0	0	1	0	0	0	7476	1087	38	1	1135	1	HTR1B	6	78173080	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3652283	78173080	92941987	201	13032											
USP45	85015	broad.mit.edu	37	chr6	99894228	99894228	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgactcagaattcatgaggcTggcaaacattaaagaatccc	15	9	8	9	0	2	4	2	2	0	2	3	4	3	4	1	2	1	2	1	2	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:99894228T>C	uc003ppx.2	-	14	1953	c.1420A>G	c.(1420-1422)AGC>GGC	p.S474G	USP45_uc003ppv.2_Intron|USP45_uc003ppw.2_Missense_Mutation_p.S154G	NM_001080481	NP_001073950	Q70EL2	UBP45_HUMAN	ubiquitin specific peptidase 45	474					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|breast(1)	2		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)		TTCATGAGGCTGGCAAACATT	0.398													11	105					0	0	0	0	C	99894228	C	C	99894228	3	2	65	1	0	0	0	0	1	0	0	0	17144	1580	55	5	1044	5	USP45	6	99894228	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	21721148	99894228	71220839	202	13033											
SEC63	11231	broad.mit.edu	37	chr6	108246120	108246120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taagaacaatgcccatcctgCaagcagaactattttcctgt	13	11	6	11	0	0	2	0	0	0	2	2	2	2	2	3	0	5	2	3	0	6	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:108246120C>T	uc003psc.3	-	3	510	c.241G>A	c.(241-243)GCA>ACA	p.A81T		NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	81	Helical; (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		GCCCATCCTGCAAGCAGAACT	0.348													8	124					0	0	0	0	T	108246120	T	T	108246120	3	4	65	1	0	0	0	0	1	0	0	0	14070	710	25	4	2117	4	SEC63	6	108246120	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	8351892	108246120	62868947	203	13034											
NR2E1	7101	broad.mit.edu	37	chr6	108492787	108492787	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgaaggaataggacctatGtctgcaaatctggaaaccag	14	8	10	9	1	2	0	0	0	2	0	3	4	3	3	3	3	2	1	3	3	6	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:108492787G>T	uc003psg.2	+	2	906	c.151G>T	c.(151-153)GTC>TTC	p.V51F		NM_003269	NP_003260	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	51	Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		TAGGACCTATGTCTGCAAATC	0.577													35	259					3.6622e-26	4.06336e-26	1	0	T	108492787	T	T	108492787	3	4	65	1	0	0	0	0	1	0	0	0	10679	1377	48	4	157	4	NR2E1	6	108492787	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	246667	108492787	62622280	204	13035											
MICAL1	64780	broad.mit.edu	37	chr6	109765452	109765452	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctgcgctcctcctggaagCggatgagggcatctctctgg	5	9	14	13	2	2	1	0	1	2	0	5	3	4	3	3	4	2	2	3	4	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:109765452C>T	uc003ptj.2	-	24	3400	c.3146G>A	c.(3145-3147)CGC>CAC	p.R1049H	MICAL1_uc003ptk.2_Missense_Mutation_p.R1049H|MICAL1_uc010kdr.2_Missense_Mutation_p.R963H|MICAL1_uc011eaq.1_Missense_Mutation_p.R1068H	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	1049					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CTCCTGGAAGCGGATGAGGGC	0.592													10	60					0	0	0	0	T	109765452	T	T	109765452	3	4	65	1	0	0	0	0	1	0	0	0	9622	768	27	1	61	1	MICAL1	6	109765452	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1272665	109765452	61349615	205	13036											
TSPYL4	23270	broad.mit.edu	37	chr6	116574172	116574172	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcctgggggtcttggcctcGgtgccagcggattggagtgg	4	9	19	9	2	1	0	0	0	1	0	2	2	1	2	3	7	3	0	3	7	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:116574172G>A	uc003pwn.2	-	1	1090	c.1000C>T	c.(1000-1002)CGA>TGA	p.R334*	DSE_uc011ebf.1_5'Flank|TSPYL4_uc011ebe.1_Nonsense_Mutation_p.R162*|uc003pwo.1_5'Flank	NM_021648	NP_067680	Q9UJ04	TSYL4_HUMAN	TSPY-like 4	334					nucleosome assembly	nucleus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.045)|OV - Ovarian serous cystadenocarcinoma(136;0.0666)|GBM - Glioblastoma multiforme(226;0.095)|Epithelial(106;0.125)		TCTTGGCCTCGGTGCCAGCGG	0.532													7	86					0	0	0	0	A	116574172	A	A	116574172	4	1	65	1	0	0	0	0	0	1	0	0	16728	1124	39	1	248	1	TSPYL4	6	116574172	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6808720	116574172	54540895	206	13037											
SLC35F1	222553	broad.mit.edu	37	chr6	118596759	118596759	+	Frame_Shift_Del	DEL	T	-	-																															tgattggtctctttggagcaTttttcagtggaattcaattg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:118596759delT	uc003pxx.3	+	5	976	c.775delT	c.(775-777)TTTfs	p.F259fs	SLC35F1_uc003pxy.1_Frame_Shift_Del_p.F64fs	NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	259	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		CTTTGGAGCATTTTTCAGTGG	0.378													---	---	---								-	118596759	-	-	118596759	7	5	65	1	0	1	0	1	0	0	0	0	14652	1493	52	0	793	0	SLC35F1	6	118596759	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	2022587	118596759	52518308	207	13038											
HBS1L	10767	broad.mit.edu	37	chr6	135363201	135363201	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagattctttcagatcttcaTaatcatattcttccacaggc	12	15	4	10	0	6	2	3	0	3	2	7	2	7	2	1	1	0	0	1	1	3	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:135363201T>C	uc003qez.2	-	3	380	c.173A>G	c.(172-174)TAT>TGT	p.Y58C	HBS1L_uc011ecy.1_5'UTR|HBS1L_uc011ecz.1_Intron|HBS1L_uc011eda.1_Intron|HBS1L_uc003qfa.2_Missense_Mutation_p.Y58C	NM_006620	NP_006611	Q9Y450	HBS1L_HUMAN	Hsp70 subfamily B suppressor 1-like protein	58					signal transduction		GTP binding|GTPase activity|translation elongation factor activity			skin(2)	2	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		CAGATCTTCATAATCATATTC	0.358													6	86					0	0	0	0	C	135363201	C	C	135363201	3	2	65	1	0	0	0	0	1	0	0	0	7026	1406	49	5	3418	5	HBS1L	6	135363201	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	16766442	135363201	35751866	208	13039											
MAP3K5	4217	broad.mit.edu	37	chr6	136913701	136913701	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccgtactcactgctgctgCtggtgtcctccaccagcaca	7	9	9	16	1	1	0	1	0	0	0	3	0	3	0	4	1	6	5	4	1	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:136913701C>G	uc003qhc.2	-	22	3291	c.2930G>C	c.(2929-2931)AGC>ACC	p.S977T	MAP3K5_uc011edj.1_Missense_Mutation_p.S224T|MAP3K5_uc011edk.1_Missense_Mutation_p.S823T	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	977					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		ACTGCTGCTGCTGGTGTCCTC	0.478													8	132					0	0	0	0	G	136913701	G	G	136913701	3	3	65	1	0	0	0	0	1	0	0	0	9306	797	28	4	1230	4	MAP3K5	6	136913701	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1550500	136913701	34201366	209	13040											
KIAA1244	57221	broad.mit.edu	37	chr6	138615205	138615205	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taccagctgaagaaagcatcGcagtctcagcttttccattc	11	11	7	12	1	1	2	1	1	1	1	5	2	2	2	2	0	4	4	2	0	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:138615205G>A	uc003qhu.2	+	20	3444	c.3444G>A	c.(3442-3444)TCG>TCA	p.S1148S		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1148					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AGAAAGCATCGCAGTCTCAGC	0.433													12	111					0	0	0	0	A	138615205	A	A	138615205	2	1	65	1	0	0	0	0	0	0	0	1	8256	1074	38	1		1	KIAA1244	6	138615205	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1701504	138615205	32499862	210	13041											
SASH1	23328	broad.mit.edu	37	chr6	148855055	148855055	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgccccaccaggaggcgtcGgaaaggacgaccaccccagc	11	1	12	17	4	0	0	0	0	0	0	1	4	0	3	6	4	1	0	6	4	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:148855055G>A	uc003qme.1	+	15	2358	c.1883G>A	c.(1882-1884)CGG>CAG	p.R628Q	SASH1_uc011eeb.1_Missense_Mutation_p.R389Q|SASH1_uc003qmf.1_Missense_Mutation_p.R38Q	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	628							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		AGGAGGCGTCGGAAAGGACGA	0.537													18	150					0	0	0	0	A	148855055	A	A	148855055	3	1	65	1	0	0	0	0	1	0	0	0	13913	1116	39	1	1941	1	SASH1	6	148855055	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	10239850	148855055	22260012	211	13042											
SYNE1	23345	broad.mit.edu	37	chr6	152826378	152826378	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccccagttctgtttcggCgatagtgaaagcatcctcca	9	11	9	12	2	1	1	0	1	1	0	5	3	4	1	4	1	1	3	4	1	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:152826378C>T	uc010kiw.2	-	9	1338	c.736G>A	c.(736-738)GCC>ACC	p.A246T	SYNE1_uc003qot.3_Missense_Mutation_p.A253T|SYNE1_uc003qou.3_Missense_Mutation_p.A246T|SYNE1_uc010kjb.1_Missense_Mutation_p.A246T|SYNE1_uc003qpa.1_Missense_Mutation_p.A246T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	246	Actin-binding.|CH 2.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCTGTTTCGGCGATAGTGAAA	0.433										HNSCC(10;0.0054)			8	101					0	0	0	0	T	152826378	T	T	152826378	3	4	65	1	0	0	0	0	1	0	0	0	15511	768	27	1	26282	1	SYNE1	6	152826378	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3971323	152826378	18288689	212	13043											
TAGAP	117289	broad.mit.edu	37	chr6	159462434	159462434	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagcctctccagatccacCgcatccccagagttgagctc	8	7	10	16	1	1	3	0	1	1	2	5	4	3	4	6	1	2	3	6	1	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:159462434C>T	uc003qrz.2	-	6	761	c.429G>A	c.(427-429)GCG>GCA	p.A143A	TAGAP_uc011eft.1_Silent_p.A80A|TAGAP_uc003qsa.2_5'UTR|TAGAP_uc003qsb.2_Silent_p.A143A|uc003qsc.2_5'Flank	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	143	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CCAGATCCACCGCATCCCCAG	0.552													8	135					0	0	0	0	T	159462434	T	T	159462434	2	4	65	1	0	0	0	0	0	0	0	1	15603	639	23	1		1	TAGAP	6	159462434	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6636056	159462434	11652633	213	13044											
IGF2R	3482	broad.mit.edu	37	chr6	160468852	160468852	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taactccacctacaacttccGgtggtacaccagctatgcct	10	10	6	15	1	0	0	0	0	0	0	2	0	2	0	5	2	6	2	5	2	5	5	rs141234361		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:160468852G>A	uc003qta.2	+	17	2406	c.2258G>A	c.(2257-2259)CGG>CAG	p.R753Q		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	753	5.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TACAACTTCCGGTGGTACACC	0.552													11	162					0	0	0	0	A	160468852	A	A	160468852	3	1	65	1	0	0	0	0	1	0	0	0	7615	1116	39	1	2324	1	IGF2R	6	160468852	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1006418	160468852	10646215	214	13045											
TCP10	6953	broad.mit.edu	37	chr6	167791449	167791450	+	Frame_Shift_Ins	INS	-	G	G																															cacgaagggtcacctttggaINSggagctaagtggttagatga																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr6:167791449_167791450insG	uc003qvv.1	-	4	622_623	c.410_411insC	c.(409-411)CCTfs	p.P137fs	TCP10_uc003qvu.2_Frame_Shift_Ins_p.P137fs|TCP10_uc003qvw.2_Frame_Shift_Ins_p.P113fs	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10	164						cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		TCACCTTTGGAGGAGCTAAGTG	0.515													---	---	---								G	167791450	G	G	167791449	7	5	65	1	0	1	1	0	0	0	0	0	15776	291	11	0	589	0	TCP10	6	167791449	Frame_Shift_Ins	INS	-	TCGA-CN-5369-01A-01D-1434-08	7322597	167791449	3323618	215	13046											
SUN1	23353	broad.mit.edu	37	chr7	899771	899771	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgttttactaggtggacGtgcaagtcagagaaatggtg	10	12	14	5	1	1	1	1	0	0	1	1	3	1	2	0	3	3	3	0	3	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:899771G>A	uc011jvp.1	+	15	1610	c.1531G>A	c.(1531-1533)GTG>ATG	p.V511M	GET4_uc003sjj.1_RNA|SUN1_uc003sjf.2_Missense_Mutation_p.V428M|SUN1_uc011jvq.1_Missense_Mutation_p.V408M|SUN1_uc003sjg.2_Missense_Mutation_p.V416M|SUN1_uc011jvr.1_Missense_Mutation_p.V309M|SUN1_uc003sji.2_Missense_Mutation_p.V349M|SUN1_uc003sjk.2_Missense_Mutation_p.V150M	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	538	Perinuclear space.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						CTAGGTGGACGTGCAAGTCAG	0.433													5	82					0	0	0	0	A	899771	A	A	899771	3	1	65	1	0	0	0	0	1	0	0	0	15457	1145	40	1	1768	1	SUN1	7	899771	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08		899771	158238892	216	13047											
RAC1	5879	broad.mit.edu	37	chr7	6441974	6441974	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatacctggagtgctcggCgctcacacagcgaggcctca	11	6	11	13	3	2	0	2	0	0	0	3	2	2	1	2	3	3	2	2	3	3	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:6441974C>T	uc003spx.2	+	6	717	c.476C>T	c.(475-477)GCG>GTG	p.A159V	RAC1_uc003spw.2_Missense_Mutation_p.A178V	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	159					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	GAGTGCTCGGCGCTCACACAG	0.567													10	89					0	0	0	0	T	6441974	T	T	6441974	3	4	65	1	0	0	0	0	1	0	0	0	13039	768	27	1	559	1	RAC1	7	6441974	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	5542203	6441974	152696689	217	13048											
GLCCI1	113263	broad.mit.edu	37	chr7	8110704	8110704	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctcccctttttgtcccccgGaatcccaggatggtagccct	5	12	8	16	1	1	0	0	0	1	0	4	2	3	2	6	3	1	1	6	3	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:8110704G>A	uc003srk.2	+	6	1679	c.1120G>A	c.(1120-1122)GAA>AAA	p.E374K		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	374											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		TTGTCCCCCGGAATCCCAGGA	0.498													15	272					0	0	0	0	A	8110704	A	A	8110704	3	1	65	1	0	0	0	0	1	0	0	0	6468	1175	41	2	1142	2	GLCCI1	7	8110704	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1668730	8110704	151027959	218	13049											
CDCA7L	55536	broad.mit.edu	37	chr7	21946011	21946011	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaggaggccgcgcactccGggttgggttcatacgccgcg	5	7	15	14	6	2	0	2	0	0	0	3	1	3	1	3	4	1	3	3	4	1	3	rs139249411		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:21946011G>A	uc010kuk.2	-	6	937	c.817C>T	c.(817-819)CGG>TGG	p.R273W	CDCA7L_uc003sve.3_Missense_Mutation_p.R239W|CDCA7L_uc010kul.2_Missense_Mutation_p.R227W|CDCA7L_uc003svf.3_Missense_Mutation_p.R272W	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	273					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						CGCGCACTCCGGGTTGGGTTC	0.527													23	275					0	0	0	0	A	21946011	A	A	21946011	3	1	65	1	0	0	0	0	1	0	0	0	3106	1115	39	1	567	1	CDCA7L	7	21946011	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	13835307	21946011	137192652	219	13050											
NPY	4852	broad.mit.edu	37	chr7	24324938	24324938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgcctgggtgcgctggccGaggcgtacccctccaagccg	4	7	15	15	4	0	0	0	0	0	0	1	1	1	0	6	3	4	2	6	3	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:24324938G>A	uc003sww.1	+	2	165	c.79G>A	c.(79-81)GAG>AAG	p.E27K		NM_000905	NP_000896	P01303	NPY_HUMAN	neuropeptide Y precursor	27					adult feeding behavior|calcium ion transport|cell proliferation|cellular component movement|central nervous system neuron development|cerebral cortex development|digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|neuron projection development|neuropeptide signaling pathway|positive regulation of appetite|synaptic transmission	cell|extracellular space	calcium channel regulator activity|G-protein coupled receptor activity|neuropeptide hormone activity				0						TGCGCTGGCCGAGGCGTACCC	0.642													8	86					0	0	0	0	A	24324938	A	A	24324938	3	1	65	1	0	0	0	0	1	0	0	0	10661	1059	37	1	81	1	NPY	7	24324938	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2378927	24324938	134813725	220	13051											
DFNA5	1687	broad.mit.edu	37	chr7	24789321	24789321	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taacttatcagagtcattcaGatttgatactgcaatcaggt	13	14	7	7	0	4	3	4	1	0	2	4	3	4	3	0	1	3	1	0	1	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:24789321G>C	uc010kus.1	-	2	161	c.73C>G	c.(73-75)CTG>GTG	p.L25V	DFNA5_uc003swz.2_Intron|DFNA5_uc003sxa.1_Missense_Mutation_p.L25V|DFNA5_uc010kut.1_Intron|DFNA5_uc003sxb.2_Missense_Mutation_p.L25V|DFNA5_uc003sxc.2_Missense_Mutation_p.L25V	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	25					sensory perception of sound					ovary(1)	1						GAGTCATTCAGATTTGATACT	0.403													27	277					0	0	0	0	C	24789321	C	C	24789321	3	2	65	1	0	0	0	0	1	0	0	0	4476	933	33	2	1453	2	DFNA5	7	24789321	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	464383	24789321	134349342	221	13052											
C7orf31	136895	broad.mit.edu	37	chr7	25176366	25176366	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaattaatcgggcaattcgtCcttccaacggtctgggaggt	9	11	12	9	3	1	0	0	0	1	0	5	2	3	1	2	4	1	1	2	4	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:25176366C>T	uc003sxn.1	-	10	1559	c.998G>A	c.(997-999)GGA>GAA	p.G333E	C7orf31_uc003sxm.1_Missense_Mutation_p.G175E	NM_138811	NP_620166	Q8N865	CG031_HUMAN	hypothetical protein LOC136895	333											0						GGCAATTCGTCCTTCCAACGG	0.433													42	307					0	0	0	0	T	25176366	T	T	25176366	3	4	65	1	0	0	0	0	1	0	0	0	2398	855	30	2	778	2	C7orf31	7	25176366	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	387045	25176366	133962297	222	13053											
PLEKHA8	84725	broad.mit.edu	37	chr7	30094365	30094365	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagatggaatggaaaacctGaaaaatcatgacaataactt	20	8	8	5	0	1	3	1	2	0	1	1	6	1	5	1	2	2	0	1	2	8	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:30094365G>A	uc003tam.1	+	8	928	c.837G>A	c.(835-837)CTG>CTA	p.L279L	PLEKHA8_uc003tao.2_Silent_p.L163L|PLEKHA8_uc003tap.1_Silent_p.L279L|PLEKHA8_uc003tan.2_Silent_p.L279L	NM_032639	NP_116028	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A	279					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4						TGGAAAACCTGAAAAATCATG	0.343													14	145					0	0	0	0	A	30094365	A	A	30094365	2	1	65	1	0	0	0	0	0	0	0	1	12117	1277	45	2		2	PLEKHA8	7	30094365	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	4917999	30094365	129044298	223	13054											
NOD1	10392	broad.mit.edu	37	chr7	30485798	30485798	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgttcttcacagccagggcGagatacttccctccttcact	7	12	7	15	1	3	1	2	0	1	1	5	2	5	1	3	1	2	1	3	1	1	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:30485798G>A	uc003tav.2	-	9	2935	c.2412C>T	c.(2410-2412)CTC>CTT	p.L804L		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	804	LRR 5.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						CAGCCAGGGCGAGATACTTCC	0.527													17	217					0	0	0	0	A	30485798	A	A	30485798	2	1	65	1	0	0	0	0	0	0	0	1	10570	1045	37	1		1	NOD1	7	30485798	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	391433	30485798	128652865	224	13055											
NPSR1	387129	broad.mit.edu	37	chr7	34724286	34724286	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accttctttgtgactcagctGgccatcacaggtaagtaact	10	12	8	11	0	3	1	2	1	1	0	3	1	3	1	2	2	2	3	2	2	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:34724286G>A	uc003teg.1	+	2	398	c.270G>A	c.(268-270)CTG>CTA	p.L90L	AAA1_uc010kwo.1_Intron|AAA1_uc010kwp.1_Intron|AAA1_uc003tdz.2_Intron|AAA1_uc010kwq.1_Intron|AAA1_uc003teb.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Silent_p.L90L|NPSR1_uc010kwt.1_5'UTR|NPSR1_uc010kwu.1_5'UTR|NPSR1_uc010kwv.1_Silent_p.L90L|NPSR1_uc003tei.1_Silent_p.L90L|NPSR1_uc010kww.1_Silent_p.L90L|NPSR1_uc011kar.1_Silent_p.L90L	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	90	Helical; Name=2; (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	TGACTCAGCTGGCCATCACAG	0.393													7	103					0	0	0	0	A	34724286	A	A	34724286	2	1	65	1	0	0	0	0	0	0	0	1	10654	1335	47	4		4	NPSR1	7	34724286	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	4238488	34724286	124414377	225	13056											
TBX20	57057	broad.mit.edu	37	chr7	35280555	35280555	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagatgaaagttctaaatTcttcagacttcaggttgagc	14	12	9	6	0	4	4	2	2	2	2	4	5	4	4	0	1	1	2	0	1	4	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:35280555T>C	uc011kas.1	-	5	760	c.749A>G	c.(748-750)GAA>GGA	p.E250G		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	250	T-box.					nucleus	DNA binding			central_nervous_system(1)	1						AGTTCTAAATTCTTCAGACTT	0.398													8	100					0	0	0	0	C	35280555	C	C	35280555	3	2	65	1	0	0	0	0	1	0	0	0	15722	1783	62	5	611	5	TBX20	7	35280555	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	556269	35280555	123858108	226	13057											
GLI3	2737	broad.mit.edu	37	chr7	42017296	42017296	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttttcaagttttctagtctcGagtaggcctttgtgcaacct	7	17	8	9	1	3	0	1	0	2	0	4	1	3	0	2	1	2	3	2	1	4	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:42017296G>C	uc011kbh.1	-	12	1764	c.1673C>G	c.(1672-1674)TCG>TGG	p.S558W	GLI3_uc011kbg.1_Missense_Mutation_p.S499W	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	558	C2H2-type 3.				negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TTCTAGTCTCGAGTAGGCCTT	0.458									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome		OREG0018015	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	139					0	0	0	0	C	42017296	C	C	42017296	3	2	65	1	0	0	0	0	1	0	0	0	6476	1059	37	3	3085	3	GLI3	7	42017296	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6736741	42017296	117121367	227	13058											
MRPS24	64951	broad.mit.edu	37	chr7	43906549	43906549	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaaacatcctccaccgttcGctctgcggcatggtcctctc	7	10	8	16	3	2	0	0	0	2	0	7	1	5	0	4	2	2	3	4	2	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:43906549G>A	uc003tit.1	-	4	304	c.253C>T	c.(253-255)CGA>TGA	p.R85*		NM_032014	NP_114403	Q96EL2	RT24_HUMAN	mitochondrial ribosomal protein S24 precursor	85					translation	mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						TCCACCGTTCGCTCTGCGGCA	0.557													11	92					0	0	0	0	A	43906549	A	A	43906549	4	1	65	1	0	0	0	0	0	1	0	0	9888	1095	38	1	254	1	MRPS24	7	43906549	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1889253	43906549	115232114	228	13059											
AEBP1	165	broad.mit.edu	37	chr7	44153765	44153765	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaacccgagtttgaggaaGaggaggaggaggagaaagag	15	4	19	3	1	0	4	0	1	0	3	0	11	0	9	1	6	1	1	1	6	3	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:44153765G>C	uc003tkb.2	+	21	3687	c.3382G>C	c.(3382-3384)GAG>CAG	p.E1128Q	AEBP1_uc003tkc.3_Missense_Mutation_p.E703Q|AEBP1_uc003tkd.2_Missense_Mutation_p.E378Q	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	1128	Required for transcriptional repression (By similarity).|Glu-rich.|Interaction with MAPK1 and MAPK3 (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GTTTgaggaagaggaggagga	0.463													5	77					0	0	0	0	C	44153765	C	C	44153765	3	2	65	1	0	0	0	0	1	0	0	0	349	943	33	2	3464	2	AEBP1	7	44153765	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	247216	44153765	114984898	229	13060											
IGFBP3	3486	broad.mit.edu	37	chr7	45956231	45956231	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattgaggaacttcaggtgAttcagtgtgtcttccatttc	9	15	9	8	0	3	2	2	2	1	0	5	3	4	3	1	2	1	0	1	2	1	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:45956231A>T	uc003tns.2	-	3	798	c.666T>A	c.(664-666)AAT>AAA	p.N222K	IGFBP3_uc003tnq.2_RNA|IGFBP3_uc003tnr.2_Missense_Mutation_p.N228K|IGFBP3_uc003tnt.2_Missense_Mutation_p.N125K	NM_000598	NP_000589	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	222	Thyroglobulin type-1.				negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(2)|lung(1)	3					Mecasermin(DB01277)	ACTTCAGGTGATTCAGTGTGT	0.463													28	226					0	0	0	0	T	45956231	T	T	45956231	3	4	65	1	0	0	0	0	1	0	0	0	7619	330	12	5	217	5	IGFBP3	7	45956231	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	1802466	45956231	113182432	230	13061											
PKD1L1	168507	broad.mit.edu	37	chr7	47906074	47906074	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aatgcatcctgtattcgtgaCcattggttgcaggaggcagt	9	12	12	8	1	0	1	0	1	0	0	2	2	1	2	2	3	2	5	2	3	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:47906074C>G	uc003tny.1	-	25	4035	c.4035G>C	c.(4033-4035)TGG>TGC	p.W1345C		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1345	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GTATTCGTGACCATTGGTTGC	0.433													11	131					0	0	0	0	G	47906074	G	G	47906074	3	3	65	1	0	0	0	0	1	0	0	0	12019	508	18	4	4646	4	PKD1L1	7	47906074	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1949843	47906074	111232589	231	13062											
PKD1L1	168507	broad.mit.edu	37	chr7	47925401	47925401	+	Frame_Shift_Del	DEL	C	-	-																															tgaaccttcctctggagcctCccccaggactgcagagtccc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:47925401delC	uc003tny.1	-	18	3088	c.3088delG	c.(3088-3090)GAGfs	p.E1030fs		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1030	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TCTGGAGCCTCCCCCAGGACT	0.622													---	---	---								-	47925401	-	-	47925401	7	5	65	1	0	1	0	1	0	0	0	0	12019	864	30	0	5621	0	PKD1L1	7	47925401	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	19327	47925401	111213262	232	13063											
ABCA13	154664	broad.mit.edu	37	chr7	48311506	48311506	+	Frame_Shift_Del	DEL	T	-	-																															gaaattattgttgcctaatcTttttgactcctccattgttc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:48311506delT	uc003toq.2	+	17	2268	c.2243delT	c.(2242-2244)CTTfs	p.L748fs	ABCA13_uc010kyr.2_Frame_Shift_Del_p.L251fs	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	748					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTGCCTAATCTTTTTGACTCC	0.348													---	---	---								-	48311506	-	-	48311506	7	5	65	1	0	1	0	1	0	0	0	0	31	1609	56	0	2138	0	ABCA13	7	48311506	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	386105	48311506	110827157	233	13064											
ABCA13	154664	broad.mit.edu	37	chr7	48428758	48428758	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caagacctcagcctgaccttCtacagagaccaaatcaccgc	13	6	6	16	1	3	3	2	1	1	2	3	4	3	3	5	0	2	0	5	0	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:48428758C>G	uc003toq.2	+	37	11620	c.11595C>G	c.(11593-11595)TTC>TTG	p.F3865L	ABCA13_uc010kys.1_Missense_Mutation_p.F939L|ABCA13_uc003tos.1_Missense_Mutation_p.F691L|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3865	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GCCTGACCTTCTACAGAGACC	0.537													10	78					0	0	0	0	G	48428758	G	G	48428758	3	3	65	1	0	0	0	0	1	0	0	0	31	912	32	2	11570	2	ABCA13	7	48428758	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	117252	48428758	110709905	234	13065											
ELN	2006	broad.mit.edu	37	chr7	73455550	73455550	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttcttatccacagttccCggagggcttgcgggtgctgg	4	13	14	10	2	1	0	0	0	1	0	3	1	3	1	2	4	2	4	2	4	1	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:73455550C>T	uc003tzw.2	+	5	292	c.201C>T	c.(199-201)CCC>CCT	p.P67P	RFC2_uc011kfa.1_Intron|ELN_uc003tzm.1_RNA|ELN_uc011kfe.1_Silent_p.P67P|ELN_uc003tzn.2_Silent_p.P67P|ELN_uc003tzz.2_Intron|ELN_uc003tzo.2_Silent_p.P67P|ELN_uc003tzp.2_Silent_p.P57P|ELN_uc003tzq.2_Silent_p.P67P|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_Silent_p.P67P|ELN_uc003tzt.2_Silent_p.P67P|ELN_uc003tzu.2_Silent_p.P67P|ELN_uc003tzv.2_Silent_p.P57P|ELN_uc003tzx.2_Silent_p.P57P|ELN_uc011kff.1_Silent_p.P67P|ELN_uc003tzy.2_Silent_p.P57P	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	67					blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CCACAGTTCCCGGAGGGCTTG	0.587			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						54	569					0	0	0	0	T	73455550	T	T	73455550	2	4	65	1	0	0	0	0	0	0	0	1	5095	639	23	1		1	ELN	7	73455550	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	25026792	73455550	85683113	235	13066											
ZNF804B	219578	broad.mit.edu	37	chr7	88962840	88962840	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatcatatccgataaacagCggtccaccatgccaaatcga	15	7	7	12	3	1	0	1	0	0	0	4	3	3	0	4	1	3	0	4	1	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:88962840C>T	uc011khi.1	+	4	1082	c.544C>T	c.(544-546)CGG>TGG	p.R182W		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	182						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CGATAAACAGCGGTCCACCAT	0.413										HNSCC(36;0.09)			10	104					0	0	0	0	T	88962840	T	T	88962840	3	4	65	1	0	0	0	0	1	0	0	0	18238	759	27	1	558	1	ZNF804B	7	88962840	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	15507290	88962840	70175823	236	13067											
ANKIB1	54467	broad.mit.edu	37	chr7	92027054	92027054	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatattccagaaggcggcAgcagcagccgcaggcctggc	10	4	14	13	2	0	2	0	0	0	2	1	2	1	2	3	4	3	4	3	4	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:92027054A>G	uc003ulw.2	+	19	2789	c.2413A>G	c.(2413-2415)AGC>GGC	p.S805G	ANKIB1_uc010lew.1_Missense_Mutation_p.S74G	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	805							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGAAGGCGGCAGCAGCAGCCG	0.458													17	271					0	0	0	0	G	92027054	G	G	92027054	3	3	65	1	0	0	0	0	1	0	0	0	630	188	7	5	2483	5	ANKIB1	7	92027054	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	3064214	92027054	67111609	237	13068											
PON3	5446	broad.mit.edu	37	chr7	94996775	94996775	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttcatgtggggatgattCacaacataaagatacacagt	15	10	9	7	0	2	2	2	1	0	1	2	4	2	3	0	2	2	0	0	2	4	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:94996775C>T	uc003unt.2	-	5	418	c.393G>A	c.(391-393)GTG>GTA	p.V131V	PON1_uc011kih.1_Intron|PON3_uc011kii.1_Silent_p.V179V	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	131					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			GGGGATGATTCACAACATAAA	0.328													15	184					0	0	0	0	T	94996775	T	T	94996775	2	4	65	1	0	0	0	0	0	0	0	1	12305	813	29	2		2	PON3	7	94996775	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2969721	94996775	64141888	238	13069											
GAL3ST4	79690	broad.mit.edu	37	chr7	99758392	99758392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtcaaaccatagtaagttgCgagcgtagtggtccccacgg	11	8	12	10	3	1	0	1	0	0	0	2	1	2	0	3	2	3	3	3	2	4	4	rs143212385		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:99758392C>T	uc003utt.2	-	3	1637	c.620G>A	c.(619-621)CGC>CAC	p.R207H	C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.R207H|GAL3ST4_uc010lgq.2_Missense_Mutation_p.R145H	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	207	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TAGTAAGTTGCGAGCGTAGTG	0.592													15	144					0	0	0	0	T	99758392	T	T	99758392	3	4	65	1	0	0	0	0	1	0	0	0	6235	768	27	1	844	1	GAL3ST4	7	99758392	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4761617	99758392	59380271	239	13070											
PSMC2	5701	broad.mit.edu	37	chr7	102996176	102996176	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acactggcctggccccaccaGcactctgggatttggctgca	7	8	11	15	0	1	0	0	0	1	0	1	1	1	1	4	4	2	3	4	4	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:102996176G>C	uc003vbs.2	+	4	296	c.226G>C	c.(226-228)GCA>CCA	p.A76P	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011kln.1_Missense_Mutation_p.A76P|PSMC2_uc011klo.1_Intron	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	76					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						GGCCCCACCAGCACTCTGGGA	0.438													7	70					0	0	0	0	C	102996176	C	C	102996176	3	2	65	1	0	0	0	0	1	0	0	0	12748	971	34	4	240	4	PSMC2	7	102996176	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3237784	102996176	56142487	240	13071											
RELN	5649	broad.mit.edu	37	chr7	103138545	103138545	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcacctcgaagatccaaaTcttgtgtaaccgcttgtctc	9	13	7	12	2	2	1	0	0	2	1	5	2	3	1	3	0	2	3	3	0	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:103138545T>A	uc003vca.2	-	54	8982	c.8822A>T	c.(8821-8823)GAT>GTT	p.D2941V	RELN_uc010liz.2_Missense_Mutation_p.D2941V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2941					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AAGATCCAAATCTTGTGTAAC	0.423													16	166					0	0	0	0	A	103138545	A	A	103138545	3	1	65	1	0	0	0	0	1	0	0	0	13285	1435	50	5	1608	5	RELN	7	103138545	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	142369	103138545	56000118	241	13072											
ORC5L	5001	broad.mit.edu	37	chr7	103835694	103835694	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaagagaacagtcacattTctgtcagcctgtaaaaagaa	18	8	8	7	0	3	3	2	0	1	3	3	4	3	3	1	0	2	1	1	0	6	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:103835694T>C	uc003vcb.2	-	5	561	c.450A>G	c.(448-450)AGA>AGG	p.R150R	ORC5L_uc011klp.1_Silent_p.R18R|ORC5L_uc003vcc.2_Silent_p.R150R|ORC5L_uc003vcd.2_Silent_p.R150R	NM_002553	NP_002544	O43913	ORC5_HUMAN	origin recognition complex subunit 5 isoform 1	150					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding				0						CAGTCACATTTCTGTCAGCCT	0.348													9	98					0	0	0	0	C	103835694	C	C	103835694	2	2	65	1	0	0	0	0	0	0	0	1	11319	1780	62	5		5	ORC5L	7	103835694	Silent	SNP	T	TCGA-CN-5369-01A-01D-1434-08	697149	103835694	55302969	242	13073											
ORC5L	5001	broad.mit.edu	37	chr7	103838195	103838195	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	attcttgtaatctaagaaatCcaggcaaaagatttgcttcc	14	13	6	8	0	2	2	0	0	2	2	4	2	4	2	2	1	1	3	2	1	5	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:103838195C>G	uc003vcb.2	-	4	530	c.419G>C	c.(418-420)GGA>GCA	p.G140A	ORC5L_uc011klp.1_Missense_Mutation_p.G8A|ORC5L_uc003vcc.2_Missense_Mutation_p.G140A|ORC5L_uc003vcd.2_Missense_Mutation_p.G140A	NM_002553	NP_002544	O43913	ORC5_HUMAN	origin recognition complex subunit 5 isoform 1	140					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding				0						TCTAAGAAATCCAGGCAAAAG	0.184													4	49					0	0	0	0	G	103838195	G	G	103838195	3	3	65	1	0	0	0	0	1	0	0	0	11319	855	30	2	1030	2	ORC5L	7	103838195	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2501	103838195	55300468	243	13074											
CTTNBP2	83992	broad.mit.edu	37	chr7	117375351	117375351	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaagtgcaggggctttcagtGctgcgattttcaagaggtgc	9	11	14	7	1	2	1	2	0	0	1	2	2	2	1	0	3	4	3	0	3	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:117375351G>A	uc003vjf.2	-	15	3752	c.3660C>T	c.(3658-3660)AGC>AGT	p.S1220S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1220										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GGCTTTCAGTGCTGCGATTTT	0.388													10	124					0	0	0	0	A	117375351	A	A	117375351	2	1	65	1	0	0	0	0	0	0	0	1	4062	1310	46	4		4	CTTNBP2	7	117375351	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	13537156	117375351	41763312	244	13075											
GPR37	2861	broad.mit.edu	37	chr7	124386639	124386639	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcgtatggtactgaaaggCgagagttcgagttccgtggt	8	10	16	7	5	0	2	0	1	0	1	2	4	1	2	1	4	1	4	1	4	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:124386639C>T	uc003vli.2	-	2	2433	c.1782G>A	c.(1780-1782)TCG>TCA	p.S594S		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	594	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						TACTGAAAGGCGAGAGTTCGA	0.463													17	182					0	0	0	0	T	124386639	T	T	124386639	2	4	65	1	0	0	0	0	0	0	0	1	6729	755	27	1		1	GPR37	7	124386639	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	7011288	124386639	34752024	245	13076											
CPA2	1358	broad.mit.edu	37	chr7	129910535	129910535	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agaattgttttatcttaggtCctgttggacaaagagaatga	13	14	10	4	0	1	3	0	1	1	2	2	5	2	4	1	2	0	2	1	2	5	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:129910535C>G	uc003vpq.2	+	4	310	c.291C>G	c.(289-291)GTC>GTG	p.V97V	CPA2_uc011kpc.1_Silent_p.V97V	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	97					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TATCTTAGGTCCTGTTGGACA	0.423													11	102					0	0	0	0	G	129910535	G	G	129910535	2	3	65	1	0	0	0	0	0	0	0	1	3805	842	30	2		2	CPA2	7	129910535	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	5523896	129910535	29228128	246	13077											
DGKI	9162	broad.mit.edu	37	chr7	137092654	137092654	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatttcacaatctccccgtTgccggttttagctgcgtagt	7	15	8	11	3	2	0	1	0	1	0	3	0	2	0	3	1	3	4	3	1	4	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:137092654T>C	uc003vtt.2	-	31	2912	c.2911A>G	c.(2911-2913)AAC>GAC	p.N971D	DGKI_uc003vtu.2_Missense_Mutation_p.N640D	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	971	ANK 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						ATCTCCCCGTTGCCGGTTTTA	0.428													12	193					0	0	0	0	C	137092654	C	C	137092654	3	2	65	1	0	0	0	0	1	0	0	0	4493	1812	63	5	302	5	DGKI	7	137092654	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	7182119	137092654	22046009	247	13078											
AKR1D1	6718	broad.mit.edu	37	chr7	137801394	137801394	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatcctgaatacccatttCatgatgaatactgactgcag	13	12	6	10	0	2	4	2	4	0	0	3	4	3	4	2	0	3	1	2	0	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:137801394C>A	uc003vtz.2	+	9	1036	c.967C>A	c.(967-969)CAT>AAT	p.H323N	AKR1D1_uc011kqe.1_3'UTR|AKR1D1_uc011kqf.1_Missense_Mutation_p.H282N|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	323					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						ATACCCATTTCATGATGAATA	0.448													10	172					4.3838e-07	4.60372e-07	1	0	A	137801394	A	A	137801394	3	1	65	1	0	0	0	0	1	0	0	0	473	826	29	2	1001	2	AKR1D1	7	137801394	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	708740	137801394	21337269	248	13079											
ATP6V0A4	50617	broad.mit.edu	37	chr7	138394405	138394405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtgcaggaaagcagagaggCcctccatgatcagaaggatg	13	5	14	9	1	1	3	1	1	0	2	2	6	2	5	2	3	2	2	2	3	2	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:138394405C>T	uc003vuf.2	-	20	2631	c.2393G>A	c.(2392-2394)GGC>GAC	p.G798D	ATP6V0A4_uc003vug.2_Missense_Mutation_p.G798D|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.G798D	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	798	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						AGCAGAGAGGCCCTCCATGAT	0.448													16	376					0	0	0	0	T	138394405	T	T	138394405	3	4	65	1	0	0	0	0	1	0	0	0	1172	739	26	4	137	4	ATP6V0A4	7	138394405	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	593011	138394405	20744258	249	13080											
TTC26	79989	broad.mit.edu	37	chr7	138874171	138874171	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccaaagaaaacagagtgtCcatctaaaatagcgccagcg	16	5	10	10	2	1	2	0	0	1	2	2	2	2	2	3	1	3	0	3	1	6	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:138874171C>A	uc003vus.2	+	18	1772	c.1658C>A	c.(1657-1659)TCC>TAC	p.S553Y	TTC26_uc011kqn.1_3'UTR|TTC26_uc011kqo.1_Missense_Mutation_p.S522Y|TTC26_uc011kqp.1_Missense_Mutation_p.S448Y|TTC26_uc003vut.2_Missense_Mutation_p.S413Y|TTC26_uc011kqq.1_Missense_Mutation_p.S422Y	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	553							binding			ovary(1)	1						AACAGAGTGTCCATCTAAAAT	0.428													20	163					3.99206e-14	4.39056e-14	1	0	A	138874171	A	A	138874171	3	1	65	1	0	0	0	0	1	0	0	0	16762	855	30	2	1728	2	TTC26	7	138874171	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	479766	138874171	20264492	250	13081											
DENND2A	27147	broad.mit.edu	37	chr7	140301642	140301642	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggagggcagtgtggggagtAacaagtccctggtaactggg	10	7	18	6	0	0	0	0	0	0	0	1	2	1	2	1	6	2	3	1	6	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:140301642A>G	uc010lnj.2	-	1	701	c.556T>C	c.(556-558)TAC>CAC	p.Y186H	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.Y186H|DENND2A_uc003vvw.2_Missense_Mutation_p.Y186H|DENND2A_uc003vvx.2_Missense_Mutation_p.Y186H	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	186										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					TGTGGGGAGTAACAAGTCCCT	0.607													9	132					0	0	0	0	G	140301642	G	G	140301642	3	3	65	1	0	0	0	0	1	0	0	0	4451	362	13	5	2545	5	DENND2A	7	140301642	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	1427471	140301642	18837021	251	13082											
OR6B1	135946	broad.mit.edu	37	chr7	143701563	143701563	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctttggcatctccctggcGaagatctacttcatctcctg	6	13	9	13	1	4	1	1	0	3	1	6	2	4	1	2	3	1	2	2	3	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:143701563G>A	uc003wdt.1	+	1	474	c.474G>A	c.(472-474)GCG>GCA	p.A158A		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					TCTCCCTGGCGAAGATCTACT	0.532													12	93					0	0	0	0	A	143701563	A	A	143701563	2	1	65	1	0	0	0	0	0	0	0	1	11241	1045	37	1		1	OR6B1	7	143701563	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3399921	143701563	15437100	252	13083											
CUL1	8454	broad.mit.edu	37	chr7	148463737	148463737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaattagcaaggaaatgtGaacaagtcctcattgaaaaa	19	9	8	5	0	1	3	1	3	0	0	2	4	2	4	1	1	2	1	1	1	8	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:148463737G>A	uc010lpg.2	+	8	1400	c.874G>A	c.(874-876)GAA>AAA	p.E292K	CUL1_uc003wey.2_Missense_Mutation_p.E292K|CUL1_uc003wez.2_Missense_Mutation_p.E182K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	292					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			AAGGAAATGTGAACAAGTCCT	0.378													12	72					0	0	0	0	A	148463737	A	A	148463737	3	1	65	1	0	0	0	0	1	0	0	0	4071	1291	45	2	900	2	CUL1	7	148463737	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	4762174	148463737	10674926	253	13084											
ZNF786	136051	broad.mit.edu	37	chr7	148767536	148767536	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caactccaatcggcctctatCattgcaaacagttggctgag	11	10	8	12	1	2	1	1	1	1	0	4	1	3	1	2	2	3	3	2	2	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:148767536C>G	uc003wfh.2	-	4	2465	c.2328G>C	c.(2326-2328)ATG>ATC	p.M776I	ZNF786_uc011kuk.1_Missense_Mutation_p.M739I|ZNF786_uc003wfi.2_Missense_Mutation_p.M690I	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	776					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CGGCCTCTATCATTGCAAACA	0.498													42	495					0	0	0	0	G	148767536	G	G	148767536	3	3	65	1	0	0	0	0	1	0	0	0	18225	826	29	2	24	2	ZNF786	7	148767536	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	303799	148767536	10371127	254	13085											
AGAP3	116988	broad.mit.edu	37	chr7	150815687	150815687	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagccactcggccgtgtccGccgcctccatcccggccgtg	3	6	11	21	6	0	0	0	0	0	0	4	0	3	0	9	2	1	0	9	2	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:150815687G>A	uc003wjg.1	+	7	940	c.937G>A	c.(937-939)GCC>ACC	p.A313T	AGAP3_uc003wje.1_Missense_Mutation_p.A85T|AGAP3_uc003wjf.1_Missense_Mutation_p.A313T|AGAP3_uc010lpy.1_Missense_Mutation_p.A313T|AGAP3_uc003wjh.1_Missense_Mutation_p.A493T|AGAP3_uc003wji.1_5'Flank	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	277	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						GGCCGTGTCCGCCGCCTCCAT	0.662													10	148					0	0	0	0	A	150815687	A	A	150815687	3	1	65	1	0	0	0	0	1	0	0	0	369	1087	38	1	963	1	AGAP3	7	150815687	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2048151	150815687	8322976	255	13086											
SMARCD3	6604	broad.mit.edu	37	chr7	150945607	150945607	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aactcaaaaagtttgcttttCgtggctttgcgcgcccctcc	7	13	8	13	3	1	0	1	0	0	0	3	0	2	0	3	1	3	3	3	1	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:150945607C>T	uc003wjs.2	-	1	143	c.42G>A	c.(40-42)ACG>ACA	p.T14T	SMARCD3_uc003wjt.2_Intron|SMARCD3_uc003wju.2_Intron|SMARCD3_uc011kvh.1_Silent_p.T14T|SMARCD3_uc010lqa.1_Silent_p.T14T	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	14					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTTTGCTTTTCGTGGCTTTGC	0.507													23	184					0	0	0	0	T	150945607	T	T	150945607	2	4	65	1	0	0	0	0	0	0	0	1	14843	871	31	1		1	SMARCD3	7	150945607	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	129920	150945607	8193056	256	13087											
MLL3	58508	broad.mit.edu	37	chr7	151884562	151884562	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaggctgaatttttatccCtgggaaaaaataaatatctt	16	14	6	5	0	1	1	0	1	1	0	2	2	2	2	1	2	0	1	1	2	10	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:151884562C>A	uc003wla.2	-	33	5013	c.4794_splice	c.e33-1	p.R1598_splice	MLL3_uc003wkz.2_Splice_Site_p.R659_splice	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATTTTTATCCCTGGGAAAAAA	0.313			N		medulloblastoma								25	197					6.36457e-07	6.66159e-07	1	0	A	151884562	A	A	151884562	5	1	65	1	0	0	0	0	0	0	1	0	9675	695	24	4	10050	4	MLL3	7	151884562	Splice_Site	SNP	C	TCGA-CN-5369-01A-01D-1434-08	938955	151884562	7254101	257	13088											
ESYT2	57488	broad.mit.edu	37	chr7	158557391	158557391	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atagacttcattccactttgGactgaggttctccttgatga	9	15	8	9	0	2	4	1	3	1	1	4	5	3	5	2	2	0	1	2	2	1	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr7:158557391G>C	uc003wob.1	-	9	1288	c.1222C>G	c.(1222-1224)CCA>GCA	p.P408A	ESYT2_uc003woc.1_Missense_Mutation_p.P232A|ESYT2_uc003wod.1_Missense_Mutation_p.P408A|ESYT2_uc003woa.1_5'Flank	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	436	C2 1.					integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						TTCCACTTTGGACTGAGGTTC	0.512													18	251					0	0	0	0	C	158557391	C	C	158557391	3	2	65	1	0	0	0	0	1	0	0	0	5289	1174	41	2	1515	2	ESYT2	7	158557391	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6672829	158557391	581272	258	13089											
RP1L1	94137	broad.mit.edu	37	chr8	10470757	10470757	+	Frame_Shift_Del	DEL	G	-	-																															tgccaggagcagggcccaccGgggggttgctaggaccaggc																								rs74594406	by1000genomes	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:10470757delG	uc003wtc.2	-	4	1080	c.851delC	c.(850-852)CCGfs	p.P284fs		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	284					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGGGCCCACCGGGGGGTTGCT	0.662													---	---	---								-	10470757	-	-	10470757	7	5	65	1	0	1	0	1	0	0	0	0	13598	1116	39	0	6355	0	RP1L1	8	10470757	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08		10470757	135893265	259	13090											
TUSC3	7991	broad.mit.edu	37	chr8	15480730	15480730	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgttatgttcactgctcttCagcctcagcggcagtgttct	5	16	9	11	1	5	0	3	0	2	0	5	0	5	0	1	1	3	5	1	1	1	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:15480730C>T	uc003wwt.2	+	2	490	c.280C>T	c.(280-282)CAG>TAG	p.Q94*	TUSC3_uc003wwr.2_Nonsense_Mutation_p.Q94*|TUSC3_uc003wws.2_Nonsense_Mutation_p.Q94*|TUSC3_uc003wwu.2_Nonsense_Mutation_p.Q94*|TUSC3_uc003wwv.2_Nonsense_Mutation_p.Q94*|TUSC3_uc003www.2_Nonsense_Mutation_p.Q94*|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Nonsense_Mutation_p.Q94*	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	94					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		CACTGCTCTTCAGCCTCAGCG	0.313													14	166					0	0	0	0	T	15480730	T	T	15480730	4	4	65	1	0	0	0	0	0	1	0	0	16846	827	29	2	286	2	TUSC3	8	15480730	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	5009973	15480730	130883292	260	13091											
PSD3	23362	broad.mit.edu	37	chr8	18729698	18729698	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatctgggaaatctctgcctGagtgtctccagttaacagcg	9	12	10	10	1	3	1	0	1	3	0	5	2	3	2	2	1	3	1	2	1	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:18729698G>A	uc003wza.2	-	3	779	c.676C>T	c.(676-678)CAG>TAG	p.Q226*		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	226					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ATCTCTGCCTGAGTGTCTCCA	0.473													16	209					0	0	0	0	A	18729698	A	A	18729698	4	1	65	1	0	0	0	0	0	1	0	0	12710	1299	45	2	2559	2	PSD3	8	18729698	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3248968	18729698	127634324	261	13092											
KIAA1967	57805	broad.mit.edu	37	chr8	22464808	22464808	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagttgatcttccagcctCaccggattcccccactcttt	6	13	5	17	1	4	1	2	1	2	0	6	2	6	2	5	1	1	1	5	1	0	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:22464808C>G	uc003xch.2	+	6	594	c.457C>G	c.(457-459)CAC>GAC	p.H153D	KIAA1967_uc003xci.2_Missense_Mutation_p.H153D|KIAA1967_uc003xcj.1_5'UTR	NM_199205	NP_954675	Q8N163	K1967_HUMAN	p30 DBC protein	153					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		CTTCCAGCCTCACCGGATTCC	0.552													5	63					0	0	0	0	G	22464808	G	G	22464808	3	3	65	1	0	0	0	0	1	0	0	0	8304	826	29	2	475	2	KIAA1967	8	22464808	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3735110	22464808	123899214	262	13093											
DOCK5	80005	broad.mit.edu	37	chr8	25250378	25250378	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgggattctcaagtggtttGaagtcaaacagatttcaaca	13	12	9	7	0	3	2	3	1	1	1	4	3	3	3	0	2	2	1	0	2	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:25250378G>C	uc003xeg.2	+	44	4644	c.4507G>C	c.(4507-4509)GAA>CAA	p.E1503Q	PPP2R2A_uc003xek.2_Intron|DOCK5_uc003xei.2_Missense_Mutation_p.E1073Q|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1503	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CAAGTGGTTTGAAGTCAAACA	0.388													3	34					0	0	0	0	C	25250378	C	C	25250378	3	2	65	1	0	0	0	0	1	0	0	0	4712	1291	45	2	4681	2	DOCK5	8	25250378	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2785570	25250378	121113644	263	13094											
MYST3	7994	broad.mit.edu	37	chr8	41798569	41798569	+	Frame_Shift_Del	DEL	C	-	-																															ctgtcctcgccagggctcaaCcccctcactgagtcttctct																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:41798569delC	uc010lxb.2	-	16	3374	c.2830delG	c.(2830-2832)GTTfs	p.V944fs	MYST3_uc010lxc.2_Frame_Shift_Del_p.V944fs|MYST3_uc003xon.3_Frame_Shift_Del_p.V944fs	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	944					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			CAGGGCTCAACCCCCTCACTG	0.552													---	---	---								-	41798569	-	-	41798569	7	5	65	1	0	1	0	1	0	0	0	0	10157	507	18	0	3196	0	MYST3	8	41798569	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	16548191	41798569	104565453	264	13095											
XKR4	114786	broad.mit.edu	37	chr8	56435944	56435944	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaagcccatcagctacatgGccgtcatcatccagttctgc	10	9	8	14	1	4	1	3	0	1	1	5	1	5	1	3	1	4	2	3	1	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:56435944G>A	uc003xsf.2	+	3	1143	c.1111G>A	c.(1111-1113)GCC>ACC	p.A371T		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	371	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			CAGCTACATGGCCGTCATCAT	0.587													8	121					0	0	0	0	A	56435944	A	A	56435944	3	1	65	1	0	0	0	0	1	0	0	0	17501	1203	42	4	1121	4	XKR4	8	56435944	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	14637375	56435944	89928078	265	13096											
TMEM68	137695	broad.mit.edu	37	chr8	56668944	56668944	+	Frame_Shift_Del	DEL	T	-	-																															tgctggtccatcttctggtaTtttttccattccatgaactt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:56668944delT	uc003xsg.1	-	2	421	c.352delA	c.(352-354)ATAfs	p.I118fs	TMEM68_uc003xsh.1_Frame_Shift_Del_p.I118fs	NM_152417	NP_689630	Q96MH6	TMM68_HUMAN	transmembrane protein 68	118						integral to membrane	acyltransferase activity			skin(1)	1			Epithelial(17;0.000361)|all cancers(17;0.00326)			TCTTCTGGTATTTTTTCCATT	0.299													---	---	---								-	56668944	-	-	56668944	7	5	65	1	0	1	0	1	0	0	0	0	16263	1493	52	0	433	0	TMEM68	8	56668944	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	233000	56668944	89695078	266	13097											
FAM110B	90362	broad.mit.edu	37	chr8	59059120	59059120	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgccaagaccgagagcggcGtgcagagggagaacctgaag	13	2	16	10	4	0	5	0	1	0	4	0	7	0	5	3	2	3	1	3	2	3	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:59059120G>A	uc003xtj.1	+	5	1211	c.331G>A	c.(331-333)GTG>ATG	p.V111M		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	111						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CGAGAGCGGCGTGCAGAGGGA	0.652													8	53					0	0	0	0	A	59059120	A	A	59059120	3	1	65	1	0	0	0	0	1	0	0	0	5425	1145	40	1	333	1	FAM110B	8	59059120	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2390176	59059120	87304902	267	13098											
VCPIP1	80124	broad.mit.edu	37	chr8	67578144	67578144	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggatataatggtttctaccGgagctgctccatgcaataca	11	11	10	9	1	1	0	0	0	1	0	2	2	2	2	2	3	5	4	2	3	5	5	rs117246146		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:67578144G>A	uc003xwn.2	-	1	1309	c.1050C>T	c.(1048-1050)TCC>TCT	p.S350S	SGK3_uc003xwp.2_5'Flank|C8orf44_uc003xwo.1_5'Flank	NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	350	OTU.				protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			GGTTTCTACCGGAGCTGCTCC	0.483													19	218					0	0	0	0	A	67578144	A	A	67578144	2	1	65	1	0	0	0	0	0	0	0	1	17209	1103	39	1		1	VCPIP1	8	67578144	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	8519024	67578144	78785878	268	13099											
LRRC67	286187	broad.mit.edu	37	chr8	67926714	67926715	+	Frame_Shift_Ins	INS	-	T	T																															ctatacatgaaatacaattgINSttttgtaggtacaagtgggt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:67926714_67926715insT	uc003xxc.2	-	3	387_388	c.242_243insA	c.(241-243)AACfs	p.N81fs		NM_001013626	NP_001013648	Q7Z4L9	LRC67_HUMAN	leucine rich repeat containing 67	81	LRR 3.										0						AAATACAATTGTTTTGTAGGTA	0.272													---	---	---								T	67926715	T	T	67926714	7	5	65	1	0	1	1	0	0	0	0	0	9069	1368	48	0	459	0	LRRC67	8	67926714	Frame_Shift_Ins	INS	-	TCGA-CN-5369-01A-01D-1434-08	348570	67926714	78437308	269	13100											
PREX2	80243	broad.mit.edu	37	chr8	69103989	69103989	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacaagtcaaattcaccacCaaactccacatccaaagctg	16	6	5	14	0	2	0	2	0	0	0	4	1	4	1	4	1	2	1	4	1	4	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:69103989C>G	uc003xxv.1	+	36	4406	c.4379C>G	c.(4378-4380)CCA>CGA	p.P1460R		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1460					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						AATTCACCACCAAACTCCACA	0.313													9	134					0	0	0	0	G	69103989	G	G	69103989	3	3	65	1	0	0	0	0	1	0	0	0	12539	594	21	4	4750	4	PREX2	8	69103989	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1177275	69103989	77260033	270	13101											
JPH1	56704	broad.mit.edu	37	chr8	75227552	75227552	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgctcgagatggaagacttgGattcggacttgcgaagtttc	9	12	13	7	3	0	2	0	0	0	2	3	7	0	5	0	3	2	2	0	3	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:75227552G>T	uc003yae.2	-	2	723	c.683C>A	c.(682-684)TCC>TAC	p.S228Y	JPH1_uc003yaf.2_Missense_Mutation_p.S228Y|JPH1_uc003yag.1_Missense_Mutation_p.S92Y	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	228	Cytoplasmic (Potential).|Ser-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GGAAGACTTGGATTCGGACTT	0.577													20	145					1.96292e-10	2.12537e-10	1	0	T	75227552	T	T	75227552	3	4	65	1	0	0	0	0	1	0	0	0	7999	1174	41	2	1318	2	JPH1	8	75227552	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6123563	75227552	71136470	271	13102											
OTUD6B	51633	broad.mit.edu	37	chr8	92083441	92083441	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaactcaccgaagatgtggCcaagttggaaaaagaaatgg	16	6	12	7	1	1	2	1	0	0	2	1	4	1	3	2	3	1	2	2	3	6	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:92083441C>T	uc003yeu.3	+	2	347	c.248C>T	c.(247-249)GCC>GTC	p.A83V	uc003yet.2_5'Flank|OTUD6B_uc011lgh.1_5'UTR	NM_016023	NP_057107	Q8N6M0	OTU6B_HUMAN	OTU domain containing 6B	53										ovary(2)|lung(1)	3			BRCA - Breast invasive adenocarcinoma(11;0.0187)			GAAGATGTGGCCAAGTTGGAA	0.393													18	96					0	0	0	0	T	92083441	T	T	92083441	3	4	65	1	0	0	0	0	1	0	0	0	11371	739	26	4	254	4	OTUD6B	8	92083441	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	16855889	92083441	54280581	272	13103											
SLC26A7	115111	broad.mit.edu	37	chr8	92352747	92352747	+	Frame_Shift_Del	DEL	A	-	-																															ctcttgctcaaggatctgccAaaaaattcaaatattcaatt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:92352747delA	uc003yex.2	+	9	1272	c.994delA	c.(994-996)AAAfs	p.K332fs	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Frame_Shift_Del_p.K332fs|SLC26A7_uc003yfa.2_Frame_Shift_Del_p.K332fs	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	332	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			AGGATCTGCCAAAAAATTCAA	0.502													---	---	---								-	92352747	-	-	92352747	7	5	65	1	0	1	0	1	0	0	0	0	14586	131	5	0	1020	0	SLC26A7	8	92352747	Frame_Shift_Del	DEL	A	TCGA-CN-5369-01A-01D-1434-08	269306	92352747	54011275	273	13104											
CSMD3	114788	broad.mit.edu	37	chr8	113317138	113317138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggaattgatgcttggacatGtaacaactatacaaaaacca	18	9	7	7	0	0	1	0	1	0	0	0	3	0	3	1	2	5	2	1	2	7	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:113317138G>A	uc003ynu.2	-	52	8237	c.8078C>T	c.(8077-8079)ACA>ATA	p.T2693I	CSMD3_uc003yns.2_Missense_Mutation_p.T1895I|CSMD3_uc003ynt.2_Missense_Mutation_p.T2653I|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2693	Extracellular (Potential).|Sushi 16.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GCTTGGACATGTAACAACTAT	0.363										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	46					0	0	0	0	A	113317138	A	A	113317138	3	1	65	1	0	0	0	0	1	0	0	0	3963	1377	48	4	3125	4	CSMD3	8	113317138	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	20964391	113317138	33046884	274	13105											
CSMD3	114788	broad.mit.edu	37	chr8	113318368	113318368	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcgttcctaccaaatagtCtgttgttagtattcctccat	8	16	6	11	2	1	0	0	0	1	0	5	0	4	0	4	0	1	4	4	0	5	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:113318368C>A	uc003ynu.2	-	51	8098	c.7939G>T	c.(7939-7941)GAC>TAC	p.D2647Y	CSMD3_uc003yns.2_Missense_Mutation_p.D1849Y|CSMD3_uc003ynt.2_Missense_Mutation_p.D2607Y|CSMD3_uc011lhx.1_Missense_Mutation_p.D2543Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2647	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACCAAATAGTCTGTTGTTAGT	0.368										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	121					0.00621372	0.00626359	1	0	A	113318368	A	A	113318368	3	1	65	1	0	0	0	0	1	0	0	0	3963	913	32	2	3268	2	CSMD3	8	113318368	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1230	113318368	33045654	275	13106											
ENPP2	5168	broad.mit.edu	37	chr8	120569896	120569896	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctagctgtgtgcatcttcatGagttcttctacccattttga	7	17	7	10	0	4	2	1	2	3	0	4	2	4	2	1	0	3	3	1	0	2	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:120569896G>C	uc003yot.1	-	25	2543	c.2457C>G	c.(2455-2457)CTC>CTG	p.L819L	ENPP2_uc011lic.1_Silent_p.L357L|ENPP2_uc003yor.1_Silent_p.L454L|ENPP2_uc003yos.1_Silent_p.L871L|ENPP2_uc010mdd.1_Silent_p.L844L	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	819					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GCATCTTCATGAGTTCTTCTA	0.463													22	203					0	0	0	0	C	120569896	C	C	120569896	2	2	65	1	0	0	0	0	0	0	0	1	5154	1277	45	2		2	ENPP2	8	120569896	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	7251528	120569896	25794126	276	13107											
TAF2	6873	broad.mit.edu	37	chr8	120772953	120772953	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcacatgtccgttcttctGaagtacccgtatggctctca	7	13	9	12	2	3	1	1	1	3	0	5	1	4	1	2	2	1	5	2	2	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:120772953G>A	uc003you.2	-	20	2854	c.2584C>T	c.(2584-2586)CAG>TAG	p.Q862*		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	862					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CCGTTCTTCTGAAGTACCCGT	0.393													24	171					0	0	0	0	A	120772953	A	A	120772953	4	1	65	1	0	0	0	0	0	1	0	0	15590	1299	45	2	1043	2	TAF2	8	120772953	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	203057	120772953	25591069	277	13108											
ZHX1	11244	broad.mit.edu	37	chr8	124266008	124266008	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actacttgaattggcgctctGatagtagtagtaccatttca	11	14	8	8	1	2	2	1	2	1	0	2	2	2	2	1	1	2	4	1	1	6	8			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:124266008G>C	uc003yqe.2	-	3	2609	c.2179C>G	c.(2179-2181)CAG>GAG	p.Q727E	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.Q727E|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.Q727E	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	727					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TTGGCGCTCTGATAGTAGTAG	0.502													21	200					0	0	0	0	C	124266008	C	C	124266008	3	2	65	1	0	0	0	0	1	0	0	0	17742	1299	45	2	446	2	ZHX1	8	124266008	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3493055	124266008	22098014	278	13109											
ZHX1	11244	broad.mit.edu	37	chr8	124267621	124267621	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccgtttattttccactttaTttttcatcattttcatgata	8	23	2	8	1	3	1	3	1	0	0	5	1	5	1	2	0	0	1	2	0	3	11			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:124267621T>C	uc003yqe.2	-	3	996	c.566A>G	c.(565-567)AAT>AGT	p.N189S	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.N189S|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.N189S	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	189					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TTCCACTTTATTTTTCATCAT	0.353													26	205					0	0	0	0	C	124267621	C	C	124267621	3	2	65	1	0	0	0	0	1	0	0	0	17742	1493	52	5	2059	5	ZHX1	8	124267621	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	1613	124267621	22096401	279	13110											
ADCY8	114	broad.mit.edu	37	chr8	131792719	131792719	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caacaaagtccgccggttgtAatgacccttgatgattcctg	10	11	9	11	2	0	3	0	3	0	0	2	3	2	3	4	1	1	2	4	1	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:131792719A>G	uc003ytd.3	-	18	3929	c.3673T>C	c.(3673-3675)TAC>CAC	p.Y1225H	ADCY8_uc010mds.2_Missense_Mutation_p.Y1094H	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1225	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CGCCGGTTGTAATGACCCTTG	0.517										HNSCC(32;0.087)			21	142					0	0	0	0	G	131792719	G	G	131792719	3	3	65	1	0	0	0	0	1	0	0	0	300	362	13	5	86	5	ADCY8	8	131792719	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	7525098	131792719	14571303	280	13111											
SLC45A4	57210	broad.mit.edu	37	chr8	142229061	142229061	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acctggttctgggtccggaaCcagctgcccaggaaggtctg	7	8	14	12	1	2	0	0	0	2	0	3	2	3	2	4	5	3	2	4	5	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:142229061C>A	uc003ywd.1	-	4	833	c.525G>T	c.(523-525)TGG>TGT	p.W175C	SLC45A4_uc003ywc.1_Missense_Mutation_p.W175C|SLC45A4_uc010meq.1_Missense_Mutation_p.W173C	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	226					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GGGTCCGGAACCAGCTGCCCA	0.652													17	121					6.94344e-10	7.49224e-10	1	0	A	142229061	A	A	142229061	3	1	65	1	0	0	0	0	1	0	0	0	14707	508	18	4	1891	4	SLC45A4	8	142229061	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	10436342	142229061	4134961	281	13112											
TOP1MT	116447	broad.mit.edu	37	chr8	144398271	144398271	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggctcggttgtaggataaGatcttagctgctatgctgtc	7	15	12	7	1	1	1	0	0	1	1	3	2	1	2	0	3	3	6	0	3	4	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:144398271G>C	uc003yxz.2	-	11	1375	c.1356C>G	c.(1354-1356)ATC>ATG	p.I452M	TOP1MT_uc011lkd.1_Missense_Mutation_p.I354M|TOP1MT_uc011lke.1_Missense_Mutation_p.I354M|TOP1MT_uc010mfb.2_Missense_Mutation_p.I354M|TOP1MT_uc011lkf.1_Missense_Mutation_p.I247M	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	452					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	TGTAGGATAAGATCTTAGCTG	0.602													15	112					0	0	0	0	C	144398271	C	C	144398271	3	2	65	1	0	0	0	0	1	0	0	0	16431	932	33	2	465	2	TOP1MT	8	144398271	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2169210	144398271	1965751	282	13113											
ZC3H3	23144	broad.mit.edu	37	chr8	144548019	144548019	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtaggagcacaccggcatCtgcagggagggccggcagtg	10	4	17	10	2	1	0	0	0	1	0	1	2	1	2	2	5	2	5	2	5	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:144548019C>T	uc003yyd.2	-	9	2205	c.2176_splice	c.e9-1	p.M726_splice		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3						mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			ACACCGGCATCTGCAGGGAGG	0.657													5	39					0	0	0	0	T	144548019	T	T	144548019	5	4	65	1	0	0	0	0	0	0	1	0	17636	927	32	2	687	2	ZC3H3	8	144548019	Splice_Site	SNP	C	TCGA-CN-5369-01A-01D-1434-08	149748	144548019	1816003	283	13114											
EPPK1	83481	broad.mit.edu	37	chr8	144947011	144947011	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtccacaacctccttcccGatggcctgaaagagggccag	9	7	10	15	1	0	2	0	1	0	1	3	3	3	2	6	2	1	0	6	2	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr8:144947011G>A	uc003zaa.1	-	1	424	c.411C>T	c.(409-411)ATC>ATT	p.I137I		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	137	Plectin 3.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTCCTTCCCGATGGCCTGAA	0.682													9	46					0	0	0	0	A	144947011	A	A	144947011	2	1	65	1	0	0	0	0	0	0	0	1	5214	1048	37	1		1	EPPK1	8	144947011	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	398992	144947011	1417011	284	13115											
MPDZ	8777	broad.mit.edu	37	chr9	13121863	13121863	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagagtgtcaggcgcactctCtgtggcgtctgtctcaggac	6	11	13	11	2	4	1	2	0	3	1	6	2	4	2	0	3	0	1	0	3	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:13121863C>G	uc010mia.1	-	37	5163	c.5106G>C	c.(5104-5106)CAG>CAC	p.Q1702H	MPDZ_uc003zkx.3_5'Flank|MPDZ_uc003zky.3_Missense_Mutation_p.Q236H|MPDZ_uc010mib.2_Missense_Mutation_p.Q407H|MPDZ_uc010mhx.2_Missense_Mutation_p.Q524H|MPDZ_uc011lmm.1_Missense_Mutation_p.Q561H|MPDZ_uc003zkz.3_Missense_Mutation_p.Q395H|MPDZ_uc010mhy.2_Missense_Mutation_p.Q1702H|MPDZ_uc010mhz.2_Missense_Mutation_p.Q1669H|MPDZ_uc011lmn.1_Missense_Mutation_p.Q1669H|MPDZ_uc003zlb.3_Missense_Mutation_p.Q1702H	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1702	PDZ 10.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		GGCGCACTCTCTGTGGCGTCT	0.498													10	52					0	0	0	0	G	13121863	G	G	13121863	3	3	65	1	0	0	0	0	1	0	0	0	9775	912	32	2	1055	2	MPDZ	9	13121863	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08		13121863	128091568	285	13116											
VCP	7415	broad.mit.edu	37	chr9	35062342	35062342	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccaatttgctcatgatctCaggacctgaaaggatacaga	14	9	9	9	0	2	3	2	2	1	1	3	5	2	5	2	2	3	1	2	2	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:35062342C>G	uc003zvy.2	-	8	1206	c.817G>C	c.(817-819)GAG>CAG	p.E273Q	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_5'UTR|VCP_uc010mki.1_Missense_Mutation_p.E228Q	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	273					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CTCATGATCTCAGGACCTGAA	0.443													15	128					0	0	0	0	G	35062342	G	G	35062342	3	3	65	1	0	0	0	0	1	0	0	0	17208	835	29	2	1643	2	VCP	9	35062342	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	21940479	35062342	106151089	286	13117											
RUSC2	9853	broad.mit.edu	37	chr9	35546558	35546558	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgactggagagaccctcatcGttcatcacatccccctggtg	8	10	9	14	1	3	2	3	1	0	1	5	4	4	3	3	2	0	1	3	2	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:35546558G>A	uc003zww.2	+	2	295	c.40G>A	c.(40-42)GTT>ATT	p.V14I	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.V14I	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	14						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GACCCTCATCGTTCATCACAT	0.582													15	202					0	0	0	0	A	35546558	A	A	35546558	3	1	65	1	0	0	0	0	1	0	0	0	13816	1145	40	1	42	1	RUSC2	9	35546558	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	484216	35546558	105666873	287	13118											
TLN1	7094	broad.mit.edu	37	chr9	35716472	35716472	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagttctccagatcacttTccccctcagcatcagccttg	7	11	8	15	0	4	1	3	0	1	1	6	2	5	2	4	1	2	2	4	1	0	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:35716472T>C	uc003zxt.2	-	20	2894	c.2540A>G	c.(2539-2541)GAA>GGA	p.E847G		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	847					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CAGATCACTTTCCCCCTCAGC	0.567													23	270					0	0	0	0	C	35716472	C	C	35716472	3	2	65	1	0	0	0	0	1	0	0	0	16013	1783	62	5	5237	5	TLN1	9	35716472	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	169914	35716472	105496959	288	13119											
RECK	8434	broad.mit.edu	37	chr9	36087862	36087862	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttcttgaaagctcacaatCtgttcaccctggagtcactg	9	14	7	11	0	5	1	3	1	2	0	5	2	5	2	1	1	1	2	1	1	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:36087862C>G	uc003zyv.2	+	9	895	c.809C>G	c.(808-810)TCT>TGT	p.S270C	RECK_uc003zyw.2_Missense_Mutation_p.S142C|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	270	5 X Knot repeats.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			AGCTCACAATCTGTTCACCCT	0.458													15	94					0	0	0	0	G	36087862	G	G	36087862	3	3	65	1	0	0	0	0	1	0	0	0	13265	913	32	2	843	2	RECK	9	36087862	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	371390	36087862	105125569	289	13120											
CBWD3	445571	broad.mit.edu	37	chr9	70871839	70871839	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatattatatattttcacgtGcagtggcttctatgttttgg	9	19	8	5	1	2	0	1	0	1	0	2	0	2	0	0	2	1	3	0	2	6	10			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:70871839G>A	uc004agi.3	+	5	542	c.433G>A	c.(433-435)GCA>ACA	p.A145T	CBWD3_uc011lro.1_Intron|CBWD3_uc004agj.3_Intron|CBWD3_uc011lrp.1_Intron|CBWD3_uc004agl.3_5'UTR	NM_201453	NP_958861	Q5JTY5	CBWD3_HUMAN	COBW domain containing 3	145							ATP binding				0				all cancers(8;0.00136)|Epithelial(8;0.0288)|GBM - Glioblastoma multiforme(74;0.0402)|OV - Ovarian serous cystadenocarcinoma(323;0.18)		ATTTTCACGTGCAGTGGCTTC	0.279													11	134					0	0	0	0	A	70871839	A	A	70871839	3	1	65	1	0	0	0	0	1	0	0	0	2726	1319	46	4	1699	4	CBWD3	9	70871839	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	34783977	70871839	70341592	290	13121											
FAM22F	54754	broad.mit.edu	37	chr9	97084496	97084496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gactcacttttccgccatctCgtagaagatcatccggtcaa	10	11	7	13	3	4	2	3	0	1	2	7	3	6	2	3	1	0	1	3	1	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:97084496C>T	uc004aup.1	-	3	850	c.829G>A	c.(829-831)GAG>AAG	p.E277K		NM_017561	NP_060031	A1L443	FA22F_HUMAN	hypothetical protein LOC54754	277											0		Acute lymphoblastic leukemia(62;0.136)				TCCGCCATCTCGTAGAAGATC	0.642													20	119					0	0	0	0	T	97084496	T	T	97084496	3	4	65	1	0	0	0	0	1	0	0	0	5573	893	31	1	1461	1	FAM22F	9	97084496	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	26212657	97084496	44128935	291	13122											
ANKS6	203286	broad.mit.edu	37	chr9	101552604	101552604	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgcgtggttggggtccGcgccccactccatcagtaga	5	8	15	13	3	1	1	1	0	0	1	3	1	3	1	4	4	1	3	4	4	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:101552604G>A	uc004ayu.2	-	2	665	c.644C>T	c.(643-645)GCG>GTG	p.A215V	ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	215	ANK 5.									ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				GTTGGGGTCCGCGCCCCACTC	0.692													7	83					0	0	0	0	A	101552604	A	A	101552604	3	1	65	1	0	0	0	0	1	0	0	0	692	1087	38	1	2027	1	ANKS6	9	101552604	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	4468108	101552604	39660827	292	13123											
SVEP1	79987	broad.mit.edu	37	chr9	113275247	113275247	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cggaccacaaaccattgggtAgacataagatgatgctgctt	13	9	10	9	1	0	3	0	1	0	2	0	4	0	4	2	2	3	3	2	2	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:113275247A>G	uc010mtz.2	-	5	1599	c.1262T>C	c.(1261-1263)CTA>CCA	p.L421P	SVEP1_uc010mua.1_Missense_Mutation_p.L421P|SVEP1_uc004beu.2_Missense_Mutation_p.L421P|SVEP1_uc004bev.2_Missense_Mutation_p.L165P	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	421	Sushi 1.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ACCATTGGGTAGACATAAGAT	0.433													6	83					0	0	0	0	G	113275247	G	G	113275247	3	3	65	1	0	0	0	0	1	0	0	0	15486	420	15	5	9629	5	SVEP1	9	113275247	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	11722643	113275247	27938184	293	13124											
ZNF618	114991	broad.mit.edu	37	chr9	116811382	116811382	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgtgcaccactgggtgcaGaacgtgctgtcggagttcgt	6	11	14	10	3	0	1	0	0	0	1	2	2	0	2	1	2	4	4	1	2	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:116811382G>C	uc004bid.2	+	15	1899	c.1800G>C	c.(1798-1800)CAG>CAC	p.Q600H	ZNF618_uc004bic.2_Missense_Mutation_p.Q507H|ZNF618_uc011lxi.1_Missense_Mutation_p.Q567H|ZNF618_uc011lxj.1_Missense_Mutation_p.Q568H|ZNF618_uc010mvb.2_Missense_Mutation_p.Q190H	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	600					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTGGGTGCAGAACGTGCTGT	0.602													20	129					0	0	0	0	C	116811382	C	C	116811382	3	2	65	1	0	0	0	0	1	0	0	0	18109	933	33	2	1575	2	ZNF618	9	116811382	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3536135	116811382	24402049	294	13125											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123234044	123234044	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accttcccgcctccgaatttCgctgatctgctcctccaagg	6	11	7	17	3	1	1	0	1	1	0	6	2	5	1	6	1	1	2	6	1	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:123234044C>T	uc004bkf.2	-	16	2021	c.1840G>A	c.(1840-1842)GAA>AAA	p.E614K	CDK5RAP2_uc004bke.2_5'UTR|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.E614K|CDK5RAP2_uc011lxw.1_5'UTR|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_5'UTR|CDK5RAP2_uc011lya.1_5'UTR|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.E614K|CDK5RAP2_uc004bki.2_Missense_Mutation_p.E413K	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	614					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CTCCGAATTTCGCTGatctgc	0.269													13	116					0	0	0	0	T	123234044	T	T	123234044	3	4	65	1	0	0	0	0	1	0	0	0	3161	893	31	1	3933	1	CDK5RAP2	9	123234044	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6422662	123234044	17979387	295	13126											
C5	727	broad.mit.edu	37	chr9	123758561	123758561	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtaacaccagaatagctttcCcttttgacaccttctggcta	10	13	6	12	0	1	2	0	1	1	1	2	2	2	2	3	1	2	3	3	1	4	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:123758561C>T	uc004bkv.2	-	22	2838	c.2808G>A	c.(2806-2808)AGG>AGA	p.R936R		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	936					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	AATAGCTTTCCCTTTTGACAC	0.323													18	294					0	0	0	0	T	123758561	T	T	123758561	2	4	65	1	0	0	0	0	0	0	0	1	2290	622	22	4		4	C5	9	123758561	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	524517	123758561	17454870	296	13127											
NOTCH1	4851	broad.mit.edu	37	chr9	139396305	139396305	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcggcatccaggtgctgctGagtccactgccggtggtctg	5	9	15	12	2	1	1	0	1	1	0	3	1	3	1	3	4	4	3	3	4	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:139396305G>A	uc004chz.2	-	30	5533	c.5533C>T	c.(5533-5535)CAG>TAG	p.Q1845*		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1845	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGGTGCTGCTGAGTCCACTGC	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			8	49					0	0	0	0	A	139396305	A	A	139396305	4	1	65	1	0	0	0	0	0	1	0	0	10601	1299	45	2	2154	2	NOTCH1	9	139396305	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	15637744	139396305	1817126	297	13128											
AGPAT2	10555	broad.mit.edu	37	chr9	139571495	139571495	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccggttgatgaagaagacgCccccgaggtacatgatgagg	11	6	15	9	3	0	6	0	4	0	2	0	7	0	6	3	3	1	2	3	3	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr9:139571495C>T	uc004cii.1	-	3	512	c.410G>A	c.(409-411)GGC>GAC	p.G137D	AGPAT2_uc004cij.1_Missense_Mutation_p.G137D	NM_006412	NP_006403	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	137	Helical; (Potential).				phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		GAAGAAGACGCCCCCGAGGTA	0.647													16	202					0	0	0	0	T	139571495	T	T	139571495	3	4	65	1	0	0	0	0	1	0	0	0	387	739	26	4	442	4	AGPAT2	9	139571495	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	175190	139571495	1641936	298	13129											
CUBN	8029	broad.mit.edu	37	chr10	16957109	16957109	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacaaacctgaccacagcagTattgctagaagtgtctatgc	13	9	9	10	0	1	2	0	1	1	1	1	3	1	2	2	0	4	3	2	0	5	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr10:16957109T>C	uc001ioo.2	-	47	7325	c.7273A>G	c.(7273-7275)ACT>GCT	p.T2425A		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2425	CUB 17.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCACAGCAGTATTGCTAGAA	0.413													15	115					0	0	0	0	C	16957109	C	C	16957109	3	2	65	1	0	0	0	0	1	0	0	0	4068	1638	57	5	3682	5	CUBN	10	16957109	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08		16957109	118577638	299	13130											
ZNF438	220929	broad.mit.edu	37	chr10	31137576	31137576	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaccctatgcacttctttCagatggccaaaatagactcg	13	10	6	12	1	2	2	1	0	1	2	3	2	2	2	2	1	2	1	2	1	5	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr10:31137576C>A	uc010qdz.1	-	7	2193	c.1758G>T	c.(1756-1758)CTG>CTT	p.L586L	ZNF438_uc001ivn.2_Silent_p.L537L|ZNF438_uc010qdy.1_Silent_p.L576L|ZNF438_uc001ivo.3_Silent_p.L150L|ZNF438_uc009xlg.2_Silent_p.L586L|ZNF438_uc001ivp.3_Silent_p.L576L|ZNF438_uc010qea.1_Silent_p.L586L|ZNF438_uc010qeb.1_Silent_p.L586L|ZNF438_uc010qec.1_Silent_p.L150L	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	586	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				GCACTTCTTTCAGATGGCCAA	0.478													22	151					3.5997e-14	3.96598e-14	1	0	A	31137576	A	A	31137576	2	1	65	1	0	0	0	0	0	0	0	1	17977	813	29	2		2	ZNF438	10	31137576	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	14180467	31137576	104397171	300	13131											
GJD4	219770	broad.mit.edu	37	chr10	35897554	35897554	+	Frame_Shift_Del	DEL	A	-	-																															aggaagtctgagtgggtgtgAaaaaaacagcacctggcggt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr10:35897554delA	uc001iyy.1	+	2	1271	c.1113delA	c.(1111-1113)TGAfs	p.*371fs		NM_153368	NP_699199	Q96KN9	CXD4_HUMAN	connexin40.1	371					cell communication	connexon complex|integral to membrane				large_intestine(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						AGTGGGTGTGAAAAAAACAGC	0.433													---	---	---								-	35897554	-	-	35897554	7	5	65	1	0	1	0	1	0	0	0	0	6456	259	9	0	1119	0	GJD4	10	35897554	Frame_Shift_Del	DEL	A	TCGA-CN-5369-01A-01D-1434-08	4759978	35897554	99637193	301	13132											
PCDH15	65217	broad.mit.edu	37	chr10	55566511	55566511	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttccttagtggcttcaccGctgtattgtcagtccccaca	6	14	8	13	1	2	0	2	0	0	0	4	0	4	0	4	1	0	4	4	1	2	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr10:55566511G>A	uc010qhq.1	-	36	5272	c.4877C>T	c.(4876-4878)GCG>GTG	p.A1626V	PCDH15_uc010qhr.1_Missense_Mutation_p.A1621V	NM_001142771	NP_001136243	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD3-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGGCTTCACCGCTGTATTGTC	0.448										HNSCC(58;0.16)			21	270					0	0	0	0	A	55566511	A	A	55566511	3	1	65	1	0	0	0	0	1	0	0	0	11565	1087	38	1	175	1	PCDH15	10	55566511	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	19668957	55566511	79968236	302	13133											
ZDHHC16	84287	broad.mit.edu	37	chr10	99215505	99215507	+	In_Frame_Del	DEL	AAG	-	-																															gcatcgaaaggcacatcaacAagaaggagagacgtcggcta																								rs146287872	byFrequency	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr10:99215505_99215507delAAG	uc001knj.2	+	10	1262_1264	c.913_915delAAG	c.(913-915)AAGdel	p.K306del	ZDHHC16_uc001knp.2_In_Frame_Del_p.K236del|ZDHHC16_uc001knk.2_In_Frame_Del_p.K306del|ZDHHC16_uc001knl.2_In_Frame_Del_p.K290del|ZDHHC16_uc001knm.2_In_Frame_Del_p.K225del|ZDHHC16_uc001knn.2_In_Frame_Del_p.K267del|ZDHHC16_uc010qow.1_In_Frame_Del_p.K288del|ZDHHC16_uc009xvq.2_RNA|ZDHHC16_uc001kno.2_In_Frame_Del_p.K272del|ZDHHC16_uc009xvr.2_In_Frame_Del_p.K297del	NM_198046	NP_932163	Q969W1	ZDH16_HUMAN	Abl-philin 2 isoform 1	306	Cytoplasmic (Potential).				apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		GCACATCAACAAGAAGGAGAGAC	0.532													---	---	---								-	99215507	-	-	99215505	7	5	65	1	0	1	0	1	0	0	0	0	17673	131	5	0	943	0	ZDHHC16	10	99215505	In_Frame_Del	DEL	AAG	TCGA-CN-5369-01A-01D-1434-08	43648994	99215505	36319242	303	13134											
DNMBP	23268	broad.mit.edu	37	chr10	101715777	101715777	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttgactacccttgaagctGaaacagaagagcccctgtaa	13	9	9	10	0	0	5	0	3	0	2	0	5	0	5	3	0	4	3	3	0	5	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr10:101715777G>C	uc001kqj.2	-	4	1546	c.1454C>G	c.(1453-1455)TCA>TGA	p.S485*	NCRNA00093_uc001kqk.1_Intron	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	485					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CCTTGAAGCTGAAACAGAAGA	0.463													12	260					0	0	0	0	C	101715777	C	C	101715777	4	2	65	1	0	0	0	0	0	1	0	0	4696	1294	45	2	3335	2	DNMBP	10	101715777	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2500272	101715777	33818970	304	13135											
PDCD11	22984	broad.mit.edu	37	chr10	105172995	105172995	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgccagaaccttggagcagtGctggatgatgttcctgtcca	8	11	12	10	0	0	2	0	1	0	1	2	4	2	4	4	2	4	3	4	2	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr10:105172995G>A	uc001kwy.1	+	9	1188	c.1101G>A	c.(1099-1101)GTG>GTA	p.V367V		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	367	S1 motif 4.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTGGAGCAGTGCTGGATGATG	0.572													16	137					0	0	0	0	A	105172995	A	A	105172995	2	1	65	1	0	0	0	0	0	0	0	1	11671	1306	46	4		4	PDCD11	10	105172995	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3457218	105172995	30361752	305	13136											
KCNK18	338567	broad.mit.edu	37	chr10	118969745	118969745	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgcaaaacaggctgattGacatatacaaaaatgttatg	16	11	9	5	0	0	2	0	2	0	0	0	2	0	2	0	2	3	3	0	2	7	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr10:118969745G>A	uc010qsr.1	+	3	1090	c.1090G>A	c.(1090-1092)GAC>AAC	p.D364N		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	364	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CAGGCTGATTGACATATACAA	0.368													10	210					0	0	0	0	A	118969745	A	A	118969745	3	1	65	1	0	0	0	0	1	0	0	0	8104	1290	45	2	1100	2	KCNK18	10	118969745	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	13796750	118969745	16565002	306	13137											
JAKMIP3	282973	broad.mit.edu	37	chr10	133950586	133950586	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accttgatcaaagtcaggatGagagagaagtcgatttcttg	13	11	11	6	1	3	3	2	2	1	2	4	7	3	4	1	1	0	0	1	1	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr10:133950586G>A	uc001lkx.3	+	6	1180	c.1180G>A	c.(1180-1182)GAG>AAG	p.E394K		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AAGTCAGGATGAGAGAGAAGT	0.512													13	84					0	0	0	0	A	133950586	A	A	133950586	3	1	65	1	0	0	0	0	1	0	0	0	7981	1291	45	2	1202	2	JAKMIP3	10	133950586	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	14980841	133950586	1584161	307	13138											
DPYSL4	10570	broad.mit.edu	37	chr10	134000594	134000594	+	Frame_Shift_Del	DEL	C	-	-																															ttccagggcaagaaaagcatCccccggatcacggtgagccc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr10:134000594delC	uc009ybb.2	+	1	181	c.27delC	c.(25-27)ATCfs	p.I9fs		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	9					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		AGAAAAGCATCCCCCGGATCA	0.502													---	---	---								-	134000594	-	-	134000594	7	5	65	1	0	1	0	1	0	0	0	0	4771	845	30	0	29	0	DPYSL4	10	134000594	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	50008	134000594	1534153	308	13139											
MUC5B	727897	broad.mit.edu	37	chr11	1269737	1269737	+	Frame_Shift_Del	DEL	C	-	-																															aaccacgggcttcacagtcaCcccctcctccagcccaggga																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:1269737delC	uc009ycr.1	+	50	13337	c.13211delC	c.(13210-13212)ACCfs	p.T4404fs	MUC5B_uc001ltb.2_Frame_Shift_Del_p.T3879fs	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3876	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TTCACAGTCACCCCCTCCTCC	0.647													---	---	---								-	1269737	-	-	1269737	7	5	65	1	0	1	0	1	0	0	0	0	10032	507	18	0	11758	0	MUC5B	11	1269737	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08		1269737	133736779	309	13140											
STIM1	6786	broad.mit.edu	37	chr11	4112527	4112527	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagggatttgacccattcCgattcggagtcctccctcca	7	11	9	14	2	0	1	0	1	0	0	5	4	4	3	5	2	1	1	5	2	0	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:4112527C>T	uc001lyv.2	+	12	2125	c.1557C>T	c.(1555-1557)TCC>TCT	p.S519S	STIM1_uc009yef.2_Nonsense_Mutation_p.R532*|STIM1_uc009yeg.2_Silent_p.S346S	NM_003156	NP_003147	Q13586	STIM1_HUMAN	stromal interaction molecule 1 precursor	519	Cytoplasmic (Potential).				activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			pancreas(1)	1		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		TGACCCATTCCGATTCGGAGT	0.463													13	159					0	0	0	0	T	4112527	T	T	4112527	2	4	65	1	0	0	0	0	0	0	0	1	15349	639	23	1		1	STIM1	11	4112527	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2842790	4112527	130893989	310	13141											
OR52R1	119695	broad.mit.edu	37	chr11	4825751	4825751	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgggtttgattataaactaGaataatttcaactgttttaa	14	18	6	3	0	1	2	1	1	0	1	1	2	1	2	0	1	2	2	0	1	8	9	rs112773148	byFrequency	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:4825751G>C	uc010qym.1	-	1	97	c.97C>G	c.(97-99)CTA>GTA	p.L33V		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	Error:Variant_position_missing_in_Q8NGF1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTATAAACTAGAATAATTTCA	0.303													9	100					0	0	0	0	C	4825751	C	C	4825751	3	2	65	1	0	0	0	0	1	0	0	0	11185	957	33	2		2	OR52R1	11	4825751	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	713224	4825751	130180765	311	13142											
OR52A4	390053	broad.mit.edu	37	chr11	5142588	5142588	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggtgctaagtgaaatgTctgtggctcctaacgtggcc	7	12	13	9	1	1	1	0	1	1	0	2	1	2	1	2	3	3	3	2	3	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:5142588T>C	uc001lzz.1	-	1	221	c.221A>G	c.(220-222)GAC>GGC	p.D74G	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AAGTGAAATGTCTGTGGCTCC	0.423													9	67					0	0	0	0	C	5142588	C	C	5142588	3	2	65	1	0	0	0	0	1	0	0	0	11163	1667	58	5	697	5	OR52A4	11	5142588	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	316837	5142588	129863928	312	13143											
OR51B6	390058	broad.mit.edu	37	chr11	5373628	5373628	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcattaaaactaagcagatTcagagtggcatacttcgttt	14	12	8	7	1	1	2	1	0	0	2	2	2	1	2	0	1	4	4	0	1	4	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:5373628T>C	uc010qzb.1	+	1	891	c.891T>C	c.(889-891)ATT>ATC	p.I297I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTAAGCAGATTCAGAGTGGCA	0.423													14	171					0	0	0	0	C	5373628	C	C	5373628	2	2	65	1	0	0	0	0	0	0	0	1	11146	1771	62	5		5	OR51B6	11	5373628	Silent	SNP	T	TCGA-CN-5369-01A-01D-1434-08	231040	5373628	129632888	313	13144											
UBQLN3	50613	broad.mit.edu	37	chr11	5530434	5530434	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggtaaatggagcttggctGagggagtgatccaggacttg	9	10	17	5	0	0	2	0	2	0	0	1	5	1	5	1	5	1	3	1	5	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:5530434G>C	uc001may.1	-	2	441	c.355C>G	c.(355-357)CAG>GAG	p.Q119E	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	119										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGCTTGGCTGAGGGAGTGAT	0.607													6	78					0	0	0	0	C	5530434	C	C	5530434	3	2	65	1	0	0	0	0	1	0	0	0	16966	1299	45	2	1616	2	UBQLN3	11	5530434	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	156806	5530434	129476082	314	13145											
CNGA4	1262	broad.mit.edu	37	chr11	6262839	6262839	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agctggtgctgaagctgcagCcccagacctactcaccaggt	9	7	11	14	0	1	2	1	1	0	1	1	2	1	2	4	2	6	4	4	2	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:6262839C>T	uc001mco.2	+	5	1203	c.1096C>T	c.(1096-1098)CCC>TCC	p.P366S	CNGA4_uc010raa.1_Missense_Mutation_p.P135S|CNGA4_uc001mcn.2_Missense_Mutation_p.P326S	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	366	cNMP.|Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAGCTGCAGCCCCAGACCTA	0.562													24	215					0	0	0	0	T	6262839	T	T	6262839	3	4	65	1	0	0	0	0	1	0	0	0	3614	739	26	4	1114	4	CNGA4	11	6262839	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	732405	6262839	128743677	315	13146											
ZNF214	7761	broad.mit.edu	37	chr11	7021140	7021140	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaagatgtgaattatgatCaaatcccttataatattcac	15	14	6	6	0	2	4	2	3	0	1	3	4	3	4	1	0	0	0	1	0	7	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:7021140C>G	uc001mfa.2	-	3	2077	c.1774G>C	c.(1774-1776)GAT>CAT	p.D592H	ZNF214_uc010ray.1_Missense_Mutation_p.D592H|ZNF214_uc009yfh.1_Missense_Mutation_p.D592H	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	592					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		GAATTATGATCAAATCCCTTA	0.333													8	69					0	0	0	0	G	7021140	G	G	7021140	3	3	65	1	0	0	0	0	1	0	0	0	17837	826	29	2	50	2	ZNF214	11	7021140	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	758301	7021140	127985376	316	13147											
NLRP14	338323	broad.mit.edu	37	chr11	7064475	7064475	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttacctgctatatttctagCttgttcacaccagtagatgg	9	16	7	9	0	2	1	1	0	1	1	2	1	2	1	2	1	3	4	2	1	5	9			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:7064475C>T	uc001mfb.1	+	4	1541	c.1218C>T	c.(1216-1218)AGC>AGT	p.S406S		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	406	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ATATTTCTAGCTTGTTCACAC	0.493													20	199					0	0	0	0	T	7064475	T	T	7064475	2	4	65	1	0	0	0	0	0	0	0	1	10530	796	28	4		4	NLRP14	11	7064475	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	43335	7064475	127942041	317	13148											
ALX4	60529	broad.mit.edu	37	chr11	44286446	44286446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcactgtgctccttggccttCatgcggagggccgcgatgct	4	10	14	13	3	1	0	1	0	0	0	2	2	2	1	3	3	3	3	3	3	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:44286446C>T	uc001myb.2	-	4	1298	c.1194G>A	c.(1192-1194)ATG>ATA	p.M398I		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	398	OAR.				hair follicle development						0						CCTTGGCCTTCATGCGGAGGG	0.667													9	70					0	0	0	0	T	44286446	T	T	44286446	3	4	65	1	0	0	0	0	1	0	0	0	558	826	29	2	45	2	ALX4	11	44286446	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	37221971	44286446	90720070	318	13149											
GLYAT	10249	broad.mit.edu	37	chr11	58480325	58480325	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctttggagtagatttggtaaGtattggtatagtgatcaagg	11	15	13	2	0	1	2	1	1	0	1	1	3	1	3	0	4	0	4	0	4	6	8			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:58480325G>A	uc001nnb.2	-	4	379	c.224C>T	c.(223-225)ACT>ATT	p.T75I	GLYAT_uc001nnc.2_Missense_Mutation_p.T75I	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	75					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	GATTTGGTAAGTATTGGTATA	0.318													12	137					0	0	0	0	A	58480325	A	A	58480325	3	1	65	1	0	0	0	0	1	0	0	0	6516	1029	36	4	682	4	GLYAT	11	58480325	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	14193879	58480325	76526191	319	13150											
OR4D11	219986	broad.mit.edu	37	chr11	59271520	59271520	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggctttgtccactccatcGtgcagatctccctgttgctg	4	13	11	13	1	1	1	0	0	1	1	5	1	3	1	3	2	2	4	3	2	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:59271520G>A	uc001noa.1	+	1	472	c.472G>A	c.(472-474)GTG>ATG	p.V158M		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCACTCCATCGTGCAGATCTC	0.547													26	252					0	0	0	0	A	59271520	A	A	59271520	3	1	65	1	0	0	0	0	1	0	0	0	11109	1145	40	1	474	1	OR4D11	11	59271520	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	791195	59271520	75734996	320	13151											
DAK	26007	broad.mit.edu	37	chr11	61106642	61106642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagggccgtggcccaggccGgcacaggtaagcctggcatg	7	5	16	13	2	1	0	1	0	0	0	1	0	1	0	4	6	1	3	4	6	1	1	rs112242971		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:61106642G>A	uc001nre.2	+	4	555	c.298G>A	c.(298-300)GGC>AGC	p.G100S	DDB1_uc010rlf.1_Intron|DAK_uc009ynm.1_Missense_Mutation_p.G30S	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	100	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						GGCCCAGGCCGGCACAGGTAA	0.672													12	76					0	0	0	0	A	61106642	A	A	61106642	3	1	65	1	0	0	0	0	1	0	0	0	4245	1116	39	1	308	1	DAK	11	61106642	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1835122	61106642	73899874	321	13152											
C11orf9	745	broad.mit.edu	37	chr11	61539102	61539102	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctgcctctgcaccccactCgagccccatcgccaccctgg	5	6	7	23	2	1	0	0	0	1	0	3	1	1	0	8	1	3	1	8	1	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:61539102C>T	uc001nsc.1	+	6	967	c.871C>T	c.(871-873)CGA>TGA	p.R291*	C11orf9_uc001nse.1_Nonsense_Mutation_p.R282*	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	291	NDT80.|Pro-rich.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GCACCCCACTCGAGCCCCATC	0.657													18	189					0	0	0	0	T	61539102	T	T	61539102	4	4	65	1	0	0	0	0	0	1	0	0	1677	876	31	1	916	1	C11orf9	11	61539102	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	432460	61539102	73467414	322	13153											
DPP3	10072	broad.mit.edu	37	chr11	66276553	66276553	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccatctcctccccaggctCagacgtgcagcttctggaat	7	10	8	16	1	3	1	1	0	2	1	6	2	5	2	4	2	2	3	4	2	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:66276553C>G	uc001oig.1	+	18	2107	c.2045C>G	c.(2044-2046)TCA>TGA	p.S682*	DPP3_uc001oif.1_Nonsense_Mutation_p.S682*|DPP3_uc010rpe.1_Nonsense_Mutation_p.S671*|DPP3_uc001oih.1_Missense_Mutation_p.Q50E|BBS1_uc001oii.1_5'UTR|BBS1_uc010rpf.1_5'Flank|BBS1_uc010rpg.1_5'Flank|BBS1_uc001oij.1_5'Flank|BBS1_uc001oik.1_5'Flank|BBS1_uc001oil.1_5'Flank	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	682					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						TCCCCAGGCTCAGACGTGCAG	0.502													13	156					0	0	0	0	G	66276553	G	G	66276553	4	3	65	1	0	0	0	0	0	1	0	0	4750	838	29	2	2111	2	DPP3	11	66276553	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4737451	66276553	68729963	323	13154											
RBM4	5936	broad.mit.edu	37	chr11	66411036	66411036	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactggtccaaagagtgtccGatagatcgttcaggccgcgt	9	9	12	11	4	1	2	1	0	0	2	4	3	3	2	3	2	0	1	3	2	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:66411036G>A	uc009yrj.2	+	3	1016	c.528G>A	c.(526-528)CCG>CCA	p.P176P	RBM4_uc009yrk.2_Silent_p.P151P|RBM4_uc001oiw.1_Silent_p.P176P|RBM4_uc001oix.1_Intron|RBM4_uc010rpj.1_Intron|RBM4_uc001oiy.1_Silent_p.P176P|RBM4_uc001oiz.1_Silent_p.P176P	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	176	CCHC-type.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		AAGAGTGTCCGATAGATCGTT	0.572													7	98					0	0	0	0	A	66411036	A	A	66411036	2	1	65	1	0	0	0	0	0	0	0	1	13199	1045	37	1		1	RBM4	11	66411036	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	134483	66411036	68595480	324	13155											
PITPNM1	9600	broad.mit.edu	37	chr11	67262398	67262398	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggacggctcctcgcattcCgccagctgtggccgctcctt	4	10	11	16	4	0	0	0	0	0	0	4	1	3	1	5	3	1	4	5	3	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:67262398C>T	uc001olx.2	-	17	2850	c.2661G>A	c.(2659-2661)GCG>GCA	p.A887A	PITPNM1_uc001olw.2_Silent_p.A169A|PITPNM1_uc001oly.2_Silent_p.A887A|PITPNM1_uc001olz.2_Silent_p.A886A	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	887					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						CCTCGCATTCCGCCAGCTGTG	0.677													12	132					0	0	0	0	T	67262398	T	T	67262398	2	4	65	1	0	0	0	0	0	0	0	1	12005	639	23	1		1	PITPNM1	11	67262398	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	851362	67262398	67744118	325	13156											
PITPNM1	9600	broad.mit.edu	37	chr11	67269818	67269818	+	Frame_Shift_Del	DEL	C	-	-																															ttgaagacgtttggctgctgCcccccatcaggcaggtaata																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:67269818delC	uc001olx.2	-	3	549	c.360delG	c.(358-360)GGGfs	p.G120fs	PITPNM1_uc001oly.2_Frame_Shift_Del_p.G120fs|PITPNM1_uc001olz.2_Frame_Shift_Del_p.G120fs	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	120					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						TTGGCTGCTGCCCCCCATCAG	0.607													---	---	---								-	67269818	-	-	67269818	7	5	65	1	0	1	0	1	0	0	0	0	12005	726	26	0	3458	0	PITPNM1	11	67269818	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	7420	67269818	67736698	326	13157											
TPCN2	219931	broad.mit.edu	37	chr11	68846367	68846367	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgcccctttcagattctcaActgcgtcttcattgtgtact	6	16	6	13	1	4	1	3	0	2	1	5	1	4	1	2	0	4	1	2	0	2	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:68846367A>G	uc001oos.2	+	16	1534	c.1418A>G	c.(1417-1419)AAC>AGC	p.N473S	TPCN2_uc001oor.2_Missense_Mutation_p.N388S|TPCN2_uc010rqg.1_Missense_Mutation_p.N473S|TPCN2_uc001oot.2_RNA	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	473	Helical; Name=S2 of repeat II; (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CAGATTCTCAACTGCGTCTTC	0.597													20	123					0	0	0	0	G	68846367	G	G	68846367	3	3	65	1	0	0	0	0	1	0	0	0	16463	43	2	5	1480	5	TPCN2	11	68846367	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	1576549	68846367	66160149	327	13158											
KRTAP5-8	57830	broad.mit.edu	37	chr11	71249137	71249137	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctctggaggctgtggctcCggctgtgggggctgcggctc	1	10	19	11	2	1	0	0	0	1	0	3	1	2	1	1	7	2	6	1	7	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:71249137C>T	uc001oqr.1	+	1	67	c.36C>T	c.(34-36)TCC>TCT	p.S12S		NM_021046	NP_066384	O75690	KRA58_HUMAN	keratin associated protein 5-8	12						extracellular region|keratin filament	structural constituent of epidermis				0						GCTGTGGCTCCGGCTGTGGGG	0.647													18	123					0	0	0	0	T	71249137	T	T	71249137	2	4	65	1	0	0	0	0	0	0	0	1	8607	639	23	1		1	KRTAP5-8	11	71249137	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2402770	71249137	63757379	328	13159											
MOGAT2	80168	broad.mit.edu	37	chr11	75431143	75431143	+	Frame_Shift_Del	DEL	G	-	-																															gaccgagacaagccacggcaGgggggccggcacatccaggc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:75431143delG	uc010rru.1	+	2	198	c.198delG	c.(196-198)CAGfs	p.Q66fs	MOGAT2_uc001oww.1_Frame_Shift_Del_p.Q66fs|MOGAT2_uc010rrv.1_5'UTR	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	66					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					AGCCACGGCAGGGGGGCCGGC	0.562													---	---	---								-	75431143	-	-	75431143	7	5	65	1	0	1	0	1	0	0	0	0	9748	991	35	0	204	0	MOGAT2	11	75431143	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	4182006	75431143	59575373	329	13160											
FAT3	120114	broad.mit.edu	37	chr11	92533399	92533399	+	Frame_Shift_Del	DEL	C	-	-																															gtcatatgtgagtgaattagCcccccggggccattttgtaa																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:92533399delC	uc001pdj.3	+	9	7237	c.7220delC	c.(7219-7221)GCCfs	p.A2407fs		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2407	Cadherin 22.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGTGAATTAGCCCCCCGGGGC	0.443										TCGA Ovarian(4;0.039)			---	---	---								-	92533399	-	-	92533399	7	5	65	1	0	1	0	1	0	0	0	0	5723	739	26	0	7254	0	FAT3	11	92533399	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	17102256	92533399	42473117	330	13161											
MTNR1B	4544	broad.mit.edu	37	chr11	92715107	92715107	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagccaagccagagagcaggCtgtgcctgaagcccagcgac	12	3	13	13	1	0	2	0	1	0	1	0	4	0	2	4	1	6	2	4	1	3	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:92715107C>T	uc001pdk.1	+	2	821	c.718C>T	c.(718-720)CTG>TTG	p.L240L		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	240	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	AGAGAGCAGGCTGTGCCTGAA	0.577													7	105					0	0	0	0	T	92715107	T	T	92715107	2	4	65	1	0	0	0	0	0	0	0	1	10005	796	28	4		4	MTNR1B	11	92715107	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	181708	92715107	42291409	331	13162											
GPR83	10888	broad.mit.edu	37	chr11	94113678	94113678	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagttgagggggaaccagcaGagggcaaagaggactaccac	14	3	15	9	0	0	3	0	1	0	2	0	5	0	5	2	4	3	3	2	4	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:94113678G>C	uc001pet.2	-	4	1081	c.909C>G	c.(907-909)CTC>CTG	p.L303L		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	303	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GGAACCAGCAGAGGGCAAAGA	0.527													9	110					0	0	0	0	C	94113678	C	C	94113678	2	2	65	1	0	0	0	0	0	0	0	1	6751	929	33	2		2	GPR83	11	94113678	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1398571	94113678	40892838	332	13163											
TRPC6	7225	broad.mit.edu	37	chr11	101362286	101362287	+	Splice_Site	INS	-	T	T																															ggcttcacgcctgaccttacINStttttttacttcatatttaa																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:101362286_101362287insT	uc001pgk.3	-	3	1553	c.1128_splice	c.e3+1	p.K376_splice	TRPC6_uc009ywy.2_Intron|TRPC6_uc009ywz.1_Splice_Site_p.K376_splice	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,						axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CCTGACCTTACTTTTTTTACTT	0.391													---	---	---								T	101362287	T	T	101362286	8	5	65	1	0	1	1	0	0	0	1	0	16650	579	20	0	1710	0	TRPC6	11	101362286	Splice_Site	INS	-	TCGA-CN-5369-01A-01D-1434-08	7248608	101362286	33644230	333	13164											
PDGFD	80310	broad.mit.edu	37	chr11	103814225	103814225	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcctcgataccgaggggTgtccagatacatattctcaa	10	10	9	12	2	1	1	1	0	1	1	4	3	2	1	4	2	3	0	4	2	4	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:103814225T>A	uc001phq.2	-	5	1099	c.727A>T	c.(727-729)ACC>TCC	p.T243S	PDGFD_uc001php.2_Missense_Mutation_p.T237S	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	243					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TACCGAGGGGTGTCCAGATAC	0.403													5	54					0	0	0	0	A	103814225	A	A	103814225	3	1	65	1	0	0	0	0	1	0	0	0	11714	1696	59	5	397	5	PDGFD	11	103814225	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	2451939	103814225	31192291	334	13165											
PDGFD	80310	broad.mit.edu	37	chr11	103814353	103814353	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caatcagagtgggatccgttActgatggagagttataggat	12	11	13	5	1	1	3	1	1	0	2	2	6	2	5	1	3	1	2	1	3	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:103814353A>G	uc001phq.2	-	5	971	c.599T>C	c.(598-600)GTA>GCA	p.V200A	PDGFD_uc001php.2_Missense_Mutation_p.V194A	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	200					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		GGGATCCGTTACTGATGGAGA	0.418													5	43					0	0	0	0	G	103814353	G	G	103814353	3	3	65	1	0	0	0	0	1	0	0	0	11714	391	14	5	525	5	PDGFD	11	103814353	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	128	103814353	31192163	335	13166											
KBTBD3	143879	broad.mit.edu	37	chr11	105924129	105924129	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatccattctttggaaagAggattgtaagattcaacatc	14	13	8	6	0	2	2	1	0	1	2	4	5	3	4	1	2	1	1	1	2	4	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:105924129A>G	uc001pja.2	-	4	1927	c.1287T>C	c.(1285-1287)CCT>CCC	p.P429P	KBTBD3_uc001pjb.2_Silent_p.P429P|KBTBD3_uc009yxm.2_Silent_p.P350P	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	425	Kelch 3.									ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		CTTTGGAAAGAGGATTGTAAG	0.383													14	97					0	0	0	0	G	105924129	G	G	105924129	2	3	65	1	0	0	0	0	0	0	0	1	8033	291	11	5		5	KBTBD3	11	105924129	Silent	SNP	A	TCGA-CN-5369-01A-01D-1434-08	2109776	105924129	29082387	336	13167											
AASDHPPT	60496	broad.mit.edu	37	chr11	105962080	105962080	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cataaaagccattggtgttgGactaggatttgaattgcagc	12	12	11	6	0	0	1	0	1	0	0	0	3	0	3	1	3	3	2	1	3	4	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:105962080G>A	uc001pjc.1	+	4	715	c.569G>A	c.(568-570)GGA>GAA	p.G190E	AASDHPPT_uc010rvn.1_RNA|AASDHPPT_uc001pjd.1_Missense_Mutation_p.G43E	NM_015423	NP_056238	Q9NRN7	ADPPT_HUMAN	aminoadipate-semialdehyde	190					macromolecule biosynthetic process|pantothenate metabolic process	cytosol	holo-[acyl-carrier-protein] synthase activity|magnesium ion binding|protein binding				0		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.78e-05)|Epithelial(105;0.00622)|all cancers(92;0.041)		ATTGGTGTTGGACTAGGATTT	0.353													18	202					0	0	0	0	A	105962080	A	A	105962080	3	1	65	1	0	0	0	0	1	0	0	0	23	1174	41	2	583	2	AASDHPPT	11	105962080	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	37951	105962080	29044436	337	13168											
EXPH5	23086	broad.mit.edu	37	chr11	108384641	108384641	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccataaccagaagaaaatgaTtcccagtgttcagaagaaac	18	7	7	9	0	1	5	1	1	0	4	2	5	2	5	3	0	2	1	3	0	6	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:108384641T>A	uc001pkk.2	-	6	1704	c.1593A>T	c.(1591-1593)GAA>GAT	p.E531D	EXPH5_uc010rvy.1_Missense_Mutation_p.E343D|EXPH5_uc010rvz.1_Missense_Mutation_p.E375D|EXPH5_uc010rwa.1_Missense_Mutation_p.E455D	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	531					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AAGAAAATGATTCCCAGTGTT	0.413													9	133					0	0	0	0	A	108384641	A	A	108384641	3	1	65	1	0	0	0	0	1	0	0	0	5347	1490	52	5	4380	5	EXPH5	11	108384641	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	2422561	108384641	26621875	338	13169											
EXPH5	23086	broad.mit.edu	37	chr11	108412381	108412381	+	Frame_Shift_Del	DEL	T	-	-																															ctaaaatctttttcttaccaTtttttgccatctccttactt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:108412381delT	uc001pkk.2	-	2	389	c.278delA	c.(277-279)AATfs	p.N93fs	EXPH5_uc010rwa.1_Frame_Shift_Del_p.N17fs	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	93					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTTCTTACCATTTTTTGCCAT	0.323													---	---	---								-	108412381	-	-	108412381	7	5	65	1	0	1	0	1	0	0	0	0	5347	1493	52	0	5711	0	EXPH5	11	108412381	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	27740	108412381	26594135	339	13170											
SIK3	23387	broad.mit.edu	37	chr11	116730111	116730111	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggctgatggagatgccgcGcccactggagcctgcagctg	6	6	17	12	2	0	2	0	1	0	1	0	4	0	3	3	4	4	3	3	4	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:116730111G>A	uc001ppy.2	-	19	2353	c.2317C>T	c.(2317-2319)CGC>TGC	p.R773C	SIK3_uc001ppz.2_Missense_Mutation_p.R672C|SIK3_uc001pqa.2_Missense_Mutation_p.R773C|SIK3_uc001ppw.2_Missense_Mutation_p.R190C|SIK3_uc001ppx.2_Missense_Mutation_p.R211C|SIK3_uc001pqb.2_Missense_Mutation_p.R76C	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	773	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.L773F(1)		ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						GAGATGCCGCGCCCACTGGAG	0.597											OREG0003491	type=REGULATORY REGION|Gene=AK022302|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	5	77					0	0	0	0	A	116730111	A	A	116730111	3	1	65	1	0	0	0	0	1	0	0	0	14384	1087	38	1	1494	1	SIK3	11	116730111	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	8317730	116730111	18276405	340	13171											
MLL	4297	broad.mit.edu	37	chr11	118352585	118352585	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtagtgagcctcctccaCgaaagcccgtcgaggaaaag	12	5	12	12	3	0	1	0	1	0	0	3	4	2	2	4	1	2	2	4	1	4	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:118352585C>T	uc001pta.2	+	7	3813	c.3790C>T	c.(3790-3792)CGA>TGA	p.R1264*	MLL_uc001ptb.2_Nonsense_Mutation_p.R1264*|MLL_uc001pte.1_RNA|MLL_uc009zab.1_Translation_Start_Site	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1264					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GCCTCCTCCACGAAAGCCCGT	0.542			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								9	87					0	0	0	0	T	118352585	T	T	118352585	4	4	65	1	0	0	0	0	0	1	0	0	9673	528	19	1	3816	1	MLL	11	118352585	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1622474	118352585	16653931	341	13172											
TTC36	143941	broad.mit.edu	37	chr11	118398294	118398294	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acattgttggattggacctcGgagaggaagcagaaaaggaa	15	7	14	5	1	0	2	0	0	0	2	1	7	0	6	1	5	1	2	1	5	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr11:118398294G>A	uc001ptg.1	+	1	85	c.85G>A	c.(85-87)GGA>AGA	p.G29R	TTC36_uc010ryb.1_RNA|TTC36_uc010ryc.1_5'UTR	NM_001080441	NP_001073910	A6NLP5	TTC36_HUMAN	tetratricopeptide repeat domain 36	29							binding				0						ATTGGACCTCGGAGAGGAAGC	0.537													24	291					0	0	0	0	A	118398294	A	A	118398294	3	1	65	1	0	0	0	0	1	0	0	0	16772	1117	39	1	87	1	TTC36	11	118398294	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	45709	118398294	16608222	342	13173											
CCDC77	84318	broad.mit.edu	37	chr12	551063	551063	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agtcgaaagtgtttggtctgGagaatgaacttagactctgt	11	13	12	5	1	2	3	0	1	2	2	3	5	2	3	0	2	1	1	0	2	4	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:551063G>C	uc001qig.2	+	13	1624	c.1444G>C	c.(1444-1446)GAG>CAG	p.E482Q	CCDC77_uc009zdk.2_Missense_Mutation_p.E450Q|CCDC77_uc010sdp.1_Missense_Mutation_p.E450Q|CCDC77_uc010sdq.1_Missense_Mutation_p.E450Q	NM_032358	NP_115734	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77 isoform a	482	Potential.					centrosome				ovary(1)	1	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			GTTTGGTCTGGAGAATGAACT	0.458													16	295					0	0	0	0	C	551063	C	C	551063	3	2	65	1	0	0	0	0	1	0	0	0	2864	1175	41	2	1486	2	CCDC77	12	551063	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08		551063	133300832	343	13174											
FOXM1	2305	broad.mit.edu	37	chr12	2968088	2968088	+	Frame_Shift_Del	DEL	G	-	-																															gagcctttgcggtgattcaaGggggggagcactttgcaagg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:2968088delG	uc001qlf.2	-	9	2273	c.2008delC	c.(2008-2010)CTTfs	p.L670fs	uc001qld.2_Intron|FOXM1_uc001qle.2_Frame_Shift_Del_p.L708fs|FOXM1_uc001qlg.2_Frame_Shift_Del_p.L655fs|FOXM1_uc009zea.2_Frame_Shift_Del_p.L655fs|FOXM1_uc009zeb.2_Frame_Shift_Del_p.L654fs	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	670					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GGTGATTCAAGGGGGGGAGCA	0.577													---	---	---								-	2968088	-	-	2968088	7	5	65	1	0	1	0	1	0	0	0	0	6052	1000	35	0	287	0	FOXM1	12	2968088	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	2417025	2968088	130883807	344	13175											
LAG3	3902	broad.mit.edu	37	chr12	6886563	6886563	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggagtttctcaggaccttgGctggaggcacaggaggccca	9	7	15	10	0	1	0	1	0	1	0	2	4	1	4	2	7	0	3	2	7	0	2	rs61731925		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:6886563G>A	uc001qqt.3	+	6	1540	c.1191G>A	c.(1189-1191)TGG>TGA	p.W397*	LAG3_uc001qqu.2_Nonsense_Mutation_p.W227*	NM_002286	NP_002277	P18627	LAG3_HUMAN	lymphocyte-activation protein 3 precursor	397	Extracellular (Potential).|Ig-like C2-type 3.					integral to membrane	antigen binding|MHC class II protein binding				0						CAGGACCTTGGCTGGAGGCAC	0.572													16	167					0	0	0	0	A	6886563	A	A	6886563	4	1	65	1	0	0	0	0	0	1	0	0	8640	1212	42	4	1213	4	LAG3	12	6886563	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3918475	6886563	126965332	345	13176											
PRH2	5555	broad.mit.edu	37	chr12	11083308	11083308	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgaggagcgtcagggaccaCctttgggaggacagcaatct	11	7	14	9	1	2	1	1	1	1	0	2	5	2	5	2	4	2	1	2	4	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:11083308C>A	uc009zhr.2	+	3	186	c.148C>A	c.(148-150)CCT>ACT	p.P50T	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH2_uc001qzh.2_Missense_Mutation_p.P50T|PRH2_uc001qzi.3_Missense_Mutation_p.P50T	NM_001110213	NP_001103683	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 2	50						extracellular space	protein binding				0						TCAGGGACCACCTTTGGGAGG	0.547													20	232					5.03518e-11	5.48023e-11	1	0	A	11083308	A	A	11083308	3	1	65	1	0	0	0	0	1	0	0	0	12545	507	18	4	158	4	PRH2	12	11083308	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4196745	11083308	122768587	346	13177											
TAS2R46	259292	broad.mit.edu	37	chr12	11214111	11214111	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaatagcttcgcagaacatGaagacaggtttgttttccag	12	11	10	8	1	0	3	0	1	0	2	2	3	1	3	1	1	2	5	1	1	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:11214111G>A	uc001qzp.1	-	1	783	c.783C>T	c.(781-783)TTC>TTT	p.F261F	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176887	NP_795368	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	261	Helical; Name=7; (Potential).				sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		CGCAGAACATGAAGACAGGTT	0.408													34	285					0	0	0	0	A	11214111	A	A	11214111	2	1	65	1	0	0	0	0	0	0	0	1	15648	1281	45	2		2	TAS2R46	12	11214111	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	130803	11214111	122637784	347	13178											
TAS2R46	259292	broad.mit.edu	37	chr12	11214216	11214216	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaggtcacagtttgcaaagcTtttatgtggaccttcatgct	9	14	10	8	0	2	0	2	0	0	0	2	2	2	1	1	2	3	4	1	2	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:11214216T>G	uc001qzp.1	-	1	678	c.678A>C	c.(676-678)AAA>AAC	p.K226N	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176887	NP_795368	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	226	Cytoplasmic (Potential).				sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		TTTGCAAAGCTTTTATGTGGA	0.403													23	303					0	0	0	0	G	11214216	G	G	11214216	3	3	65	1	0	0	0	0	1	0	0	0	15648	1606	56	5	255	5	TAS2R46	12	11214216	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	105	11214216	122637679	348	13179											
LRP6	4040	broad.mit.edu	37	chr12	12274078	12274078	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctcaggaggagtctgtacaGggagagggtggcggtgggta	8	7	20	6	1	2	1	1	0	1	1	2	4	2	3	1	7	1	2	1	7	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:12274078G>A	uc001rah.3	-	23	4966	c.4824C>T	c.(4822-4824)CCC>CCT	p.P1608P	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Silent_p.P1563P	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1608	Cytoplasmic (Potential).|PPPSP motif E.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				AGTCTGTACAGGGAGAGGGTG	0.527													5	54					0	0	0	0	A	12274078	A	A	12274078	2	1	65	1	0	0	0	0	0	0	0	1	9012	987	35	4		4	LRP6	12	12274078	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1059862	12274078	121577817	349	13180											
PIK3C2G	5288	broad.mit.edu	37	chr12	18435201	18435202	+	Frame_Shift_Ins	INS	-	T	T																															gtgaaattgatgaaaacaccINSttttttgtgcccactgcacc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:18435201_18435202insT	uc001rdt.2	+	2	302_303	c.186_187insT	c.(184-189)ACCTTTfs	p.T62fs	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Frame_Shift_Ins_p.T62fs|PIK3C2G_uc010sic.1_5'UTR	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	62_63					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				ATGAAAACACCTTTTTTGTGCC	0.406													---	---	---								T	18435202	T	T	18435201	7	5	65	1	0	1	1	0	0	0	0	0	11966	668	24	0	188	0	PIK3C2G	12	18435201	Frame_Shift_Ins	INS	-	TCGA-CN-5369-01A-01D-1434-08	6161123	18435201	115416694	350	13181											
KRAS	3845	broad.mit.edu	37	chr12	25368473	25368473	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcggatctccctcaccaatgTataaaaagcatcctccactc	12	10	4	15	1	2	0	1	0	1	0	7	1	4	1	4	1	1	2	4	1	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:25368473T>C	uc001rgp.1	-	5	653	c.472A>G	c.(472-474)ACA>GCA	p.T158A	KRAS_uc001rgq.1_Intron	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	158					activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CTCACCAATGTATAAAAAGCA	0.353		119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			10	128					0	0	0	0	C	25368473	C	C	25368473	3	2	65	1	0	0	0	0	1	0	0	0	8477	1638	57	5	222	5	KRAS	12	25368473	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	6933272	25368473	108483422	351	13182											
MED21	9412	broad.mit.edu	37	chr12	27181336	27181337	+	Frame_Shift_Del	DEL	CA	-	-																															aagcgcacttgctgatattgCacagtcacagctgaagacaa																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:27181336_27181337delCA	uc001rhp.1	+	4	407_408	c.377_378delCA	c.(376-378)GCAfs	p.A126fs	MED21_uc009zjh.1_RNA	NM_004264	NP_004255	Q13503	MED21_HUMAN	mediator complex subunit 21	126					positive regulation of transcription from RNA polymerase II promoter	mediator complex	DNA-directed RNA polymerase activity|transcription coactivator activity				0	Colorectal(261;0.0847)					GCTGATATTGCACAGTCACAGC	0.45													---	---	---								-	27181337	-	-	27181336	7	5	65	1	0	1	0	1	0	0	0	0	9492	710	25	0	391	0	MED21	12	27181336	Frame_Shift_Del	DEL	CA	TCGA-CN-5369-01A-01D-1434-08	1812863	27181336	106670559	352	13183											
KIF21A	55605	broad.mit.edu	37	chr12	39735313	39735313	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagggcaagtacctttttCatctgattcagaatctgatt	12	14	7	8	0	4	3	2	2	2	1	4	3	4	3	1	1	1	2	1	1	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:39735313C>G	uc001rly.2	-	14	2061	c.1915G>C	c.(1915-1917)GAA>CAA	p.E639Q	KIF21A_uc001rlw.2_5'Flank|KIF21A_uc001rlx.2_Missense_Mutation_p.E626Q|KIF21A_uc001rlz.2_Missense_Mutation_p.E626Q|KIF21A_uc010skl.1_Missense_Mutation_p.E626Q	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	639					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				GTACCTTTTTCATCTGATTCA	0.289													7	104					0	0	0	0	G	39735313	G	G	39735313	3	3	65	1	0	0	0	0	1	0	0	0	8327	835	29	2	3209	2	KIF21A	12	39735313	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	12553977	39735313	94116582	353	13184											
ZCRB1	85437	broad.mit.edu	37	chr12	42707703	42707703	+	Frame_Shift_Del	DEL	T	-	-																															cttctggttcaggagctttcTtttttttctttttttctttc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:42707703delT	uc001rmz.2	-	6	628	c.419delA	c.(418-420)AAGfs	p.K140fs	PPHLN1_uc001rmy.2_Intron	NM_033114	NP_149105	Q8TBF4	ZCRB1_HUMAN	zinc finger CCHC-type and RNA binding motif 1	140	Poly-Lys.				mRNA processing	nucleoplasm|U12-type spliceosomal complex	nucleotide binding|RNA binding|zinc ion binding			skin(1)	1	all_cancers(12;0.000348)|Breast(8;0.221)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0689)		AGGAGCTTTCTTTTTTTTCTT	0.343													---	---	---								-	42707703	-	-	42707703	7	5	65	1	0	1	0	1	0	0	0	0	17663	1609	56	0	246	0	ZCRB1	12	42707703	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	2972390	42707703	91144192	354	13185											
SFRS2IP	9169	broad.mit.edu	37	chr12	46322292	46322292	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcattggaagatgatttttCaggggcagctacagagctcc	11	11	11	8	0	2	3	2	1	0	2	3	4	3	4	1	3	3	3	1	3	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:46322292C>G	uc001rox.2	-	11	1479	c.1192G>C	c.(1192-1194)GAA>CAA	p.E398Q	SFRS2IP_uc001row.2_Missense_Mutation_p.E83Q|SFRS2IP_uc001roy.1_Missense_Mutation_p.E472Q	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	398					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		GATGATTTTTCAGGGGCAGCT	0.408													26	194					0	0	0	0	G	46322292	G	G	46322292	3	3	65	1	0	0	0	0	1	0	0	0	14242	835	29	2	3219	2	SFRS2IP	12	46322292	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3614589	46322292	87529603	355	13186											
CCDC65	85478	broad.mit.edu	37	chr12	49312494	49312494	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataactatttcaaaaggcaaGatcatgatacacagccgtga	17	9	7	8	1	2	3	2	2	0	1	2	3	2	3	1	1	3	1	1	1	6	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:49312494G>C	uc001rso.2	+	6	1061	c.834G>C	c.(832-834)AAG>AAC	p.K278N		NM_033124	NP_149115	Q8IXS2	CCD65_HUMAN	coiled-coil domain containing 65	278										ovary(1)|skin(1)	2						CAAAAGGCAAGATCATGATAC	0.433													8	70					0	0	0	0	C	49312494	C	C	49312494	3	2	65	1	0	0	0	0	1	0	0	0	2850	933	33	2	856	2	CCDC65	12	49312494	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2990202	49312494	84539401	356	13187											
LASS5	91012	broad.mit.edu	37	chr12	50536932	50536932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaaccagcattggatttttCggacattccaatccagctgc	11	11	8	11	1	0	0	0	0	0	0	3	3	2	2	3	2	4	2	3	2	2	4	rs146511812		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:50536932C>T	uc001rwd.3	-	3	376	c.359G>A	c.(358-360)CGA>CAA	p.R120Q	LASS5_uc001rwc.2_Missense_Mutation_p.R39Q|LASS5_uc001rwe.3_Missense_Mutation_p.R61Q|LASS5_uc001rwf.3_RNA|LASS5_uc010smq.1_5'UTR	NM_147190	NP_671723	Q8N5B7	CERS5_HUMAN	LAG1 homolog, ceramide synthase 5	120	Cytoplasmic (Potential).|Homeobox.				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0						TTGGATTTTTCGGACATTCCA	0.493													38	428					0	0	0	0	T	50536932	T	T	50536932	3	4	65	1	0	0	0	0	1	0	0	0	8682	884	31	1	851	1	LASS5	12	50536932	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1224438	50536932	83314963	357	13188											
KRT75	9119	broad.mit.edu	37	chr12	52824378	52824378	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgcggttggcaatgtcctCgtattgtgctttgacctcgg	4	14	13	10	3	0	1	0	1	0	0	3	1	1	1	2	3	2	5	2	3	2	4	rs143629874		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:52824378C>T	uc001saj.2	-	5	1004	c.982G>A	c.(982-984)GAG>AAG	p.E328K		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	328	Coil 2.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		GCAATGTCCTCGTATTGTGCT	0.572													15	275					0	0	0	0	T	52824378	T	T	52824378	3	4	65	1	0	0	0	0	1	0	0	0	8527	893	31	1	693	1	KRT75	12	52824378	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2287446	52824378	81027517	358	13189											
KRT4	3851	broad.mit.edu	37	chr12	53200995	53200995	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cggagccacttcctaatcctCcgctgatgcctccagtgctg	6	10	9	16	2	0	1	0	1	0	0	4	2	4	2	6	1	3	2	6	1	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:53200995C>T	uc001saz.2	-	9	1914	c.1643G>A	c.(1642-1644)GGA>GAA	p.G548E		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	474						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						TCCTAATCCTCCGCTGATGCC	0.577													7	63					0	0	0	0	T	53200995	T	T	53200995	3	4	65	1	0	0	0	0	1	0	0	0	8516	855	30	2	145	2	KRT4	12	53200995	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	376617	53200995	80650900	359	13190											
HOXC13	3229	broad.mit.edu	37	chr12	54338828	54338828	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcagctaccggcgcgggCgcaagaaacgcgtgccctac	9	4	14	14	6	0	2	0	1	0	1	0	2	0	2	2	2	6	3	2	2	4	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:54338828C>T	uc001sei.2	+	2	896	c.781C>T	c.(781-783)CGC>TGC	p.R261C	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	261	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CCGGCGCGGGCGCAAGAAACG	0.602			T	NUP98	AML								21	197					0	0	0	0	T	54338828	T	T	54338828	3	4	65	1	0	0	0	0	1	0	0	0	7351	768	27	1	787	1	HOXC13	12	54338828	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1137833	54338828	79513067	360	13191											
NFE2	4778	broad.mit.edu	37	chr12	54686499	54686499	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactagcgctagctggctctCtgtcagcgggtaccttgcca	6	10	12	13	2	2	0	1	0	1	0	3	1	2	0	2	2	5	4	2	2	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:54686499C>T	uc009znk.2	-	2	1291	c.781G>A	c.(781-783)GAG>AAG	p.E261K	NFE2_uc001sfq.2_Missense_Mutation_p.E261K|NFE2_uc001sfr.3_Missense_Mutation_p.E261K|NFE2_uc009znl.2_Missense_Mutation_p.E261K	NM_006163	NP_006154	Q16621	NFE2_HUMAN	nuclear factor, erythroid derived 2 isoform 1	261					blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding				0						AGCTGGCTCTCTGTCAGCGGG	0.542													15	82					0	0	0	0	T	54686499	T	T	54686499	3	4	65	1	0	0	0	0	1	0	0	0	10420	922	32	2	344	2	NFE2	12	54686499	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	347671	54686499	79165396	361	13192											
COPZ1	22818	broad.mit.edu	37	chr12	54741612	54741612	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctgttcttggctgtggatGaaattgtagatggagggtaa	9	13	16	3	0	1	2	0	1	1	1	1	4	1	4	0	5	0	5	0	5	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:54741612G>A	uc001sfs.1	+	6	416	c.379G>A	c.(379-381)GAA>AAA	p.E127K	COPZ1_uc001sft.2_Missense_Mutation_p.E76K|COPZ1_uc009znm.1_Missense_Mutation_p.E135K|COPZ1_uc010sot.1_Missense_Mutation_p.E104K	NM_016057	NP_057141	P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	127					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol					0						GGCTGTGGATGAAATTGTAGA	0.502													8	63					0	0	0	0	A	54741612	A	A	54741612	3	1	65	1	0	0	0	0	1	0	0	0	3756	1291	45	2	401	2	COPZ1	12	54741612	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	55113	54741612	79110283	362	13193											
NCKAP1L	3071	broad.mit.edu	37	chr12	54894338	54894338	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacatttaggaccagtacatCgtgaaaaagccgagataatt	17	9	8	7	2	0	2	0	1	0	1	1	4	0	3	2	1	3	1	2	1	6	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:54894338C>T	uc001sgc.3	+	3	314	c.235C>T	c.(235-237)CGT>TGT	p.R79C	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.R29C	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	79					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						ACCAGTACATCGTGAAAAAGC	0.378													12	223					0	0	0	0	T	54894338	T	T	54894338	3	4	65	1	0	0	0	0	1	0	0	0	10276	884	31	1	245	1	NCKAP1L	12	54894338	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	152726	54894338	78957557	363	13194											
BAZ2A	11176	broad.mit.edu	37	chr12	57005681	57005681	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagctgctggggaagttacGggagaggcttttggggatgt	7	10	19	5	1	0	1	0	0	0	1	0	4	0	3	0	6	3	5	0	6	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:57005681G>A	uc001slq.1	-	6	1685	c.1491C>T	c.(1489-1491)CCC>CCT	p.P497P	BAZ2A_uc001slp.1_Silent_p.P495P|BAZ2A_uc009zow.1_Silent_p.P465P	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	497					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						GGGAAGTTACGGGAGAGGCTT	0.542													4	24					0	0	0	0	A	57005681	A	A	57005681	2	1	65	1	0	0	0	0	0	0	0	1	1333	1103	39	1		1	BAZ2A	12	57005681	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2111343	57005681	76846214	364	13195											
RDH16	8608	broad.mit.edu	37	chr12	57348692	57348692	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccatcccagacccatacctGagggagtcagagaaggcttc	11	6	10	14	0	1	3	1	1	0	2	3	5	2	4	4	2	1	1	4	2	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:57348692G>A	uc001smi.3	-	2	742	c.570C>T	c.(568-570)CTC>CTT	p.L190L	RDH16_uc009zpa.2_Intron	NM_003708	NP_003699	O75452	RDH16_HUMAN	retinol dehydrogenase 16	190	Cytoplasmic (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity				0						ACCCATACCTGAGGGAGTCAG	0.567													6	70					0	0	0	0	A	57348692	A	A	57348692	2	1	65	1	0	0	0	0	0	0	0	1	13259	1277	45	2		2	RDH16	12	57348692	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	343011	57348692	76503203	365	13196											
LRP1	4035	broad.mit.edu	37	chr12	57572242	57572242	+	Frame_Shift_Del	DEL	G	-	-																															cgtttgcagtgacgctgtacGggggggaggtctactggact																								rs139915490		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:57572242delG	uc001snd.2	+	27	4928	c.4462delG	c.(4462-4464)GGGfs	p.G1488fs		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1488	Extracellular (Potential).|LDL-receptor class B 11.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GACGCTGTACGGGGGGGAGGT	0.587													---	---	---								-	57572242	-	-	57572242	7	5	65	1	0	1	0	1	0	0	0	0	9001	1116	39	0	4568	0	LRP1	12	57572242	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	223550	57572242	76279653	366	13197											
PPM1H	57460	broad.mit.edu	37	chr12	63195772	63195772	+	Frame_Shift_Del	DEL	C	-	-																															gggcgtgttctcaggctcctCccccaggcaggtagggggca																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:63195772delC	uc001srk.3	-	3	729	c.580delG	c.(580-582)GAGfs	p.E194fs		NM_020700	NP_065751	Q9ULR3	PPM1H_HUMAN	protein phosphatase 1H (PP2C domain containing)	194	PP2C-like.						phosphoprotein phosphatase activity			lung(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		TCAGGCTCCTCCCCCAGGCAG	0.716													---	---	---								-	63195772	-	-	63195772	7	5	65	1	0	1	0	1	0	0	0	0	12401	864	30	0	996	0	PPM1H	12	63195772	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	5623530	63195772	70656123	367	13198											
CAND1	55832	broad.mit.edu	37	chr12	67699281	67699281	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttctgacttgcctaatacActtcagattttcttggagag	9	15	9	8	0	3	3	1	1	2	2	3	4	3	3	1	2	2	1	1	2	2	8			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:67699281A>G	uc001stn.2	+	10	2270	c.1833A>G	c.(1831-1833)ACA>ACG	p.T611T	CAND1_uc001sto.2_Intron	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	611	HEAT 14.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TGCCTAATACACTTCAGATTT	0.393													16	323					0	0	0	0	G	67699281	G	G	67699281	2	3	65	1	0	0	0	0	0	0	0	1	2627	146	6	5		5	CAND1	12	67699281	Silent	SNP	A	TCGA-CN-5369-01A-01D-1434-08	4503509	67699281	66152614	368	13199											
MGAT4C	25834	broad.mit.edu	37	chr12	86373610	86373610	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaaaacggatcacatttttCtgagccaacagaccacggaa	15	9	7	10	2	2	2	1	1	1	1	2	4	2	4	2	2	3	0	2	2	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:86373610C>G	uc001tai.3	-	8	2144	c.894G>C	c.(892-894)CAG>CAC	p.Q298H	MGAT4C_uc001tal.3_Missense_Mutation_p.Q298H|MGAT4C_uc001taj.3_Missense_Mutation_p.Q298H|MGAT4C_uc001tak.3_Missense_Mutation_p.Q298H|MGAT4C_uc010sum.1_Missense_Mutation_p.Q322H|MGAT4C_uc001tah.3_Missense_Mutation_p.Q298H	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	298	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TCACATTTTTCTGAGCCAACA	0.383													13	128					0	0	0	0	G	86373610	G	G	86373610	3	3	65	1	0	0	0	0	1	0	0	0	9600	912	32	2	546	2	MGAT4C	12	86373610	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	18674329	86373610	47478285	369	13200											
TMTC3	160418	broad.mit.edu	37	chr12	88553917	88553917	+	Frame_Shift_Del	DEL	T	-	-																															ctccaattgccttgacagtgTttttagtggctgttgcaaca																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:88553917delT	uc001tau.2	+	5	755	c.535delT	c.(535-537)TTTfs	p.F179fs	TMTC3_uc009zsm.2_RNA	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	179	Helical; (Potential).					integral to membrane	binding			skin(1)	1						CTTGACAGTGTTTTTAGTGGC	0.318													---	---	---								-	88553917	-	-	88553917	7	5	65	1	0	1	0	1	0	0	0	0	16328	1725	60	0	549	0	TMTC3	12	88553917	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	2180307	88553917	45297978	370	13201											
GALNT4	8693	broad.mit.edu	37	chr12	89917031	89917031	+	Frame_Shift_Del	DEL	A	-	-																															tctggaacatgtaaattaggAaaaacgtttttcaaatacca																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:89917031delA	uc001tbd.2	-	1	1505	c.1296delT	c.(1294-1296)TTTfs	p.F432fs	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Frame_Shift_Del_p.F429fs|GALNT4_uc010suo.1_Frame_Shift_Del_p.F124fs	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	432	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						GTAAATTAGGAAAAACGTTTT	0.403													---	---	---								-	89917031	-	-	89917031	7	5	65	1	0	1	0	1	0	0	0	0	6250	243	9	0	444	0	GALNT4	12	89917031	Frame_Shift_Del	DEL	A	TCGA-CN-5369-01A-01D-1434-08	1363114	89917031	43934864	371	13202											
ELK3	2004	broad.mit.edu	37	chr12	96641121	96641121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggtgtccctgccttccaCgtcagaggctgcggcggcgt	3	9	16	13	4	1	1	1	0	0	1	3	1	3	1	3	5	2	1	3	5	0	1	rs118124881	byFrequency	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:96641121C>T	uc001teo.1	+	3	890	c.611C>T	c.(610-612)ACG>ATG	p.T204M		NM_005230	NP_005221	P41970	ELK3_HUMAN	ELK3 protein	204					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	all_cancers(2;0.00173)					CTGCCTTCCACGTCAGAGGCT	0.587													20	118					0	0	0	0	T	96641121	T	T	96641121	3	4	65	1	0	0	0	0	1	0	0	0	5084	536	19	1	617	1	ELK3	12	96641121	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6724090	96641121	37210774	372	13203											
NEDD1	121441	broad.mit.edu	37	chr12	97345732	97345732	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcctgtttttctagaatgaAatgcattctttgctggaaag	10	17	8	6	0	2	2	0	1	2	1	3	3	3	3	1	1	2	3	1	1	4	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:97345732A>T	uc001teu.3	+	16	2223	c.1884A>T	c.(1882-1884)GAA>GAT	p.E628D	NEDD1_uc001tev.3_Missense_Mutation_p.E628D|NEDD1_uc010svc.1_Missense_Mutation_p.E539D|NEDD1_uc001tew.2_Missense_Mutation_p.E635D|NEDD1_uc001tex.2_Missense_Mutation_p.E539D	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	628					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						TCTAGAATGAAATGCATTCTT	0.323													9	93					0	0	0	0	T	97345732	T	T	97345732	3	4	65	1	0	0	0	0	1	0	0	0	10363	11	1	5	1963	5	NEDD1	12	97345732	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	704611	97345732	36506163	373	13204											
NUAK1	9891	broad.mit.edu	37	chr12	106464625	106464625	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttttgtgatcgaaaccatcGaagggcattgttccataaac	12	13	8	8	2	0	1	0	1	0	0	3	3	1	1	2	1	2	2	2	1	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:106464625G>A	uc001tlj.1	-	6	2139	c.759C>T	c.(757-759)TTC>TTT	p.F253F		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	253	Protein kinase.						ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						CGAAACCATCGAAGGGCATTG	0.547													10	98					0	0	0	0	A	106464625	A	A	106464625	2	1	65	1	0	0	0	0	0	0	0	1	10766	1049	37	1		1	NUAK1	12	106464625	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	9118893	106464625	27387270	374	13205											
TPCN1	53373	broad.mit.edu	37	chr12	113704019	113704019	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgacaagttcttcacccaccCcaaggatgccaaggcgctgg	10	6	10	15	2	2	0	1	0	1	0	2	2	2	1	4	3	1	2	4	3	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:113704019C>T	uc001tuw.2	+	4	569	c.272C>T	c.(271-273)CCC>CTC	p.P91L	TPCN1_uc001tux.2_Missense_Mutation_p.P163L|TPCN1_uc010syt.1_Missense_Mutation_p.P23L	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	91	Cytoplasmic (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						TTCACCCACCCCAAGGATGCC	0.582													35	381					0	0	0	0	T	113704019	T	T	113704019	3	4	65	1	0	0	0	0	1	0	0	0	16462	623	22	4	502	4	TPCN1	12	113704019	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	7239394	113704019	20147876	375	13206											
TPCN1	53373	broad.mit.edu	37	chr12	113714796	113714796	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtctttgctactgcacaagCgaaccgctatccagcatgcc	10	9	8	14	2	1	0	0	0	1	0	2	1	2	0	3	0	7	4	3	0	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:113714796C>T	uc001tuw.2	+	11	1312	c.1015C>T	c.(1015-1017)CGA>TGA	p.R339*	TPCN1_uc001tux.2_Nonsense_Mutation_p.R411*|TPCN1_uc010syt.1_Nonsense_Mutation_p.R271*	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	339	Cytoplasmic (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						ACTGCACAAGCGAACCGCTAT	0.567													44	373					0	0	0	0	T	113714796	T	T	113714796	4	4	65	1	0	0	0	0	0	1	0	0	16462	760	27	1	1273	1	TPCN1	12	113714796	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	10777	113714796	20137099	376	13207											
TBX5	6910	broad.mit.edu	37	chr12	114832546	114832547	+	Frame_Shift_Ins	INS	-	T	T																															tcctgggcttcaggcttaccINSttgtggttctggtaggaagt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:114832546_114832547insT	uc001tvo.2	-	6	1157_1158	c.662_663insA	c.(661-663)AAGfs	p.K221fs	TBX5_uc001tvp.2_Frame_Shift_Ins_p.K221fs|TBX5_uc001tvq.2_Frame_Shift_Ins_p.K171fs|TBX5_uc010syv.1_Frame_Shift_Ins_p.K221fs	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	221	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TCAGGCTTACCTTGTGGTTCTG	0.485													---	---	---								T	114832547	T	T	114832546	7	5	65	1	0	1	1	0	0	0	0	0	15727	695	24	0	976	0	TBX5	12	114832546	Frame_Shift_Ins	INS	-	TCGA-CN-5369-01A-01D-1434-08	1117750	114832546	19019349	377	13208											
CIT	11113	broad.mit.edu	37	chr12	120150457	120150457	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgaatagatacatccccGtcgggaaggcacagctcaaa	14	6	9	12	2	1	2	1	1	0	1	3	3	2	3	3	2	2	2	3	2	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:120150457G>A	uc001txi.1	-	35	4550	c.4497C>T	c.(4495-4497)GAC>GAT	p.D1499D	CIT_uc001txh.1_Silent_p.D1018D|CIT_uc001txj.1_Silent_p.D1541D	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1499	PH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		ATACATCCCCGTCGGGAAGGC	0.458													10	88					0	0	0	0	A	120150457	A	A	120150457	2	1	65	1	0	0	0	0	0	0	0	1	3453	1136	40	1		1	CIT	12	120150457	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	5317911	120150457	13701438	378	13209											
SBNO1	55206	broad.mit.edu	37	chr12	123832576	123832576	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgaatctaaatcattcttacCctcacatttaatagtgctgg	12	14	5	10	1	4	0	2	0	2	0	4	1	4	0	1	1	2	1	1	1	6	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:123832576C>A	uc010tap.1	-	2	237	c.237G>T	c.(235-237)AGG>AGT	p.R79S	SBNO1_uc010tao.1_Missense_Mutation_p.R79S|SBNO1_uc010taq.1_5'UTR|SBNO1_uc001uet.2_Missense_Mutation_p.R79S|SBNO1_uc001ueu.2_Missense_Mutation_p.R79S|SBNO1_uc001uev.2_Intron|SBNO1_uc009zxy.1_Intron	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	79							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TCATTCTTACCCTCACATTTA	0.313													9	114					1.76689e-08	1.88389e-08	1	0	A	123832576	A	A	123832576	3	1	65	1	0	0	0	0	1	0	0	0	13927	637	22	4	4064	4	SBNO1	12	123832576	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3682119	123832576	10019319	379	13210											
DHX37	57647	broad.mit.edu	37	chr12	125449066	125449066	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtagtagcgtttcttgaccTtcccacagtccaccacgtac	8	11	7	15	3	1	1	0	1	1	0	3	1	3	1	4	0	2	4	4	0	3	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr12:125449066T>A	uc001ugy.2	-	15	2018	c.1919A>T	c.(1918-1920)AAG>ATG	p.K640M		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	640	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TTTCTTGACCTTCCCACAGTC	0.607													9	121					0	0	0	0	A	125449066	A	A	125449066	3	1	65	1	0	0	0	0	1	0	0	0	4532	1609	56	5	1606	5	DHX37	12	125449066	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	1616490	125449066	8402829	380	13211											
SLC7A1	6541	broad.mit.edu	37	chr13	30104749	30104749	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtttttaaccgatcctttCacaaatcctgacaccattat	12	14	3	12	1	1	1	1	1	0	0	3	2	3	1	4	0	1	1	4	0	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:30104749C>T	uc001uso.2	-	5	1017	c.630G>A	c.(628-630)GTG>GTA	p.V210V		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	210	Helical; (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CCGATCCTTTCACAAATCCTG	0.443													19	215					0	0	0	0	T	30104749	T	T	30104749	2	4	65	1	0	0	0	0	0	0	0	1	14756	813	29	2		2	SLC7A1	13	30104749	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08		30104749	85065129	381	13212											
B3GALTL	145173	broad.mit.edu	37	chr13	31822041	31822041	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttggattttcttctgtgaaGaagagacaagaatacagatt	14	13	9	5	0	2	5	0	1	2	4	2	7	2	6	0	1	1	0	0	1	5	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:31822041G>A	uc010aaz.2	+	6	507	c.397G>A	c.(397-399)GAA>AAA	p.E133K		NM_194318	NP_919299	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	133	Lumenal (Potential).				fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		CTTCTGTGAAGAAGAGACAAG	0.333													12	100					0	0	0	0	A	31822041	A	A	31822041	3	1	65	1	0	0	0	0	1	0	0	0	1254	943	33	2	419	2	B3GALTL	13	31822041	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1717292	31822041	83347837	382	13213											
N4BP2L2	10443	broad.mit.edu	37	chr13	33017343	33017343	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgaaaaatcttcatttcctAtcagtagtttgtctgtcaat	11	17	6	7	0	5	1	3	1	2	0	6	1	6	1	1	0	0	2	1	0	5	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:33017343A>G	uc010abe.1	-	7	1353	c.1331T>C	c.(1330-1332)ATA>ACA	p.I444T	N4BP2L2_uc001uug.2_Missense_Mutation_p.I327T|N4BP2L2_uc010abd.1_Missense_Mutation_p.I357T|N4BP2L2_uc001uuh.2_Missense_Mutation_p.I275T|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Missense_Mutation_p.I429T	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TTCATTTCCTATCAGTAGTTT	0.418													13	104					0	0	0	0	G	33017343	G	G	33017343	3	3	65	1	0	0	0	0	1	0	0	0	10165	449	16	5	939	5	N4BP2L2	13	33017343	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	1195302	33017343	82152535	383	13214											
KIAA0564	23078	broad.mit.edu	37	chr13	42461382	42461382	+	Frame_Shift_Del	DEL	G	-	-																															cttgaaatcgagaacgaagaGgggggtctaatggattccca																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:42461382delG	uc001uyj.2	-	6	837	c.767delC	c.(766-768)CCTfs	p.P256fs	KIAA0564_uc001uyk.2_Frame_Shift_Del_p.P256fs	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	256						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		AGAACGAAGAGGGGGGTCTAA	0.383													---	---	---								-	42461382	-	-	42461382	7	5	65	1	0	1	0	1	0	0	0	0	8224	1000	35	0	5114	0	KIAA0564	13	42461382	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	9444039	42461382	72708496	384	13215											
LPAR6	10161	broad.mit.edu	37	chr13	48985612	48985612	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgcaccatgaacttcagaGaatctgaagtcacttctcct	11	12	6	12	0	5	3	2	2	3	1	6	4	5	3	2	0	2	1	2	0	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:48985612G>C	uc010acu.2	-	1	2042	c.948C>G	c.(946-948)TTC>TTG	p.F316L	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Missense_Mutation_p.F316L|LPAR6_uc001vcf.2_Missense_Mutation_p.F316L	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	316	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						GAACTTCAGAGAATCTGAAGT	0.338													15	158					0	0	0	0	C	48985612	C	C	48985612	3	2	65	1	0	0	0	0	1	0	0	0	8959	933	33	2	90	2	LPAR6	13	48985612	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6524230	48985612	66184266	385	13216											
PCDH17	27253	broad.mit.edu	37	chr13	58299367	58299367	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatgcagaggaagttgtgaGagaaattgataagcttttgc	13	11	14	3	0	0	4	0	2	0	2	0	7	0	6	0	2	3	3	0	2	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:58299367G>C	uc001vhq.1	+	4	4311	c.3419G>C	c.(3418-3420)AGA>ACA	p.R1140T	PCDH17_uc010aec.1_Missense_Mutation_p.R1139T|PCDH17_uc001vhr.1_Missense_Mutation_p.R229T	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1140	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GAAGTTGTGAGAGAAATTGAT	0.488													28	328					0	0	0	0	C	58299367	C	C	58299367	3	2	65	1	0	0	0	0	1	0	0	0	11566	942	33	2	3433	2	PCDH17	13	58299367	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	9313755	58299367	56870511	386	13217											
DIAPH3	81624	broad.mit.edu	37	chr13	60686226	60686226	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatctctaaaggtgctgctGagcaatcactgcttgcaaat	11	12	8	10	0	3	1	2	1	1	0	4	1	3	1	0	1	5	5	0	1	4	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:60686226G>A	uc001vht.2	-	3	527	c.308C>T	c.(307-309)TCA>TTA	p.S103L	DIAPH3_uc001vhw.1_Missense_Mutation_p.S92L|DIAPH3_uc010aed.1_Missense_Mutation_p.S92L|DIAPH3_uc010aee.1_Intron	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	103					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AGGTGCTGCTGAGCAATCACT	0.408													32	380					0	0	0	0	A	60686226	A	A	60686226	3	1	65	1	0	0	0	0	1	0	0	0	4542	1294	45	2	3397	2	DIAPH3	13	60686226	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2386859	60686226	54483652	387	13218											
KLF5	688	broad.mit.edu	37	chr13	73636025	73636025	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgaaatggagaagtatctGacacctcagcttcctccagt	11	11	9	10	0	2	3	1	2	1	1	4	4	4	3	3	1	1	2	3	1	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:73636025G>C	uc001vje.2	+	2	612	c.288G>C	c.(286-288)CTG>CTC	p.L96L	KLF5_uc001vjd.2_Silent_p.L5L	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	96					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		AGAAGTATCTGACACCTCAGC	0.428													23	220					0	0	0	0	C	73636025	C	C	73636025	2	2	65	1	0	0	0	0	0	0	0	1	8388	1277	45	2		2	KLF5	13	73636025	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	12949799	73636025	41533853	388	13219											
SLITRK6	84189	broad.mit.edu	37	chr13	86368721	86368722	+	Frame_Shift_Ins	INS	-	T	T																															tttgctcatctacttgtttcINStttttgtatcttctcctgcg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:86368721_86368722insT	uc001vll.1	-	2	2381_2382	c.1922_1923insA	c.(1921-1923)AAGfs	p.K641fs	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	641	Cytoplasmic (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CTACTTGTTTCTTTTTGTATCT	0.411													---	---	---								T	86368722	T	T	86368721	7	5	65	1	0	1	1	0	0	0	0	0	14811	912	32	0	606	0	SLITRK6	13	86368721	Frame_Shift_Ins	INS	-	TCGA-CN-5369-01A-01D-1434-08	12732696	86368721	28801157	389	13220											
FAM155A	728215	broad.mit.edu	37	chr13	108518310	108518310	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acaagttccagagcggagtgGgatgcttgctcctcacctcc	8	9	11	13	1	1	1	1	0	0	1	4	3	4	3	4	2	3	3	4	2	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:108518310G>T	uc001vql.2	-	1	1151	c.635C>A	c.(634-636)CCC>CAC	p.P212H		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	212						integral to membrane	binding			skin(1)	1						GAGCGGAGTGGGATGCTTGCT	0.587													11	206					0.000673444	0.000684341	1	0	T	108518310	T	T	108518310	3	4	65	1	0	0	0	0	1	0	0	0	5493	1232	43	4	753	4	FAM155A	13	108518310	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	22149589	108518310	6651568	390	13221											
LIG4	3981	broad.mit.edu	37	chr13	108861664	108861664	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atattagaaattttgttaacGttagtaaggttaggtgcttt	12	18	9	2	1	0	1	0	0	0	1	0	1	0	1	0	2	2	5	0	2	7	9			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:108861664G>A	uc001vqn.2	-	2	2226	c.1953C>T	c.(1951-1953)AAC>AAT	p.N651N	LIG4_uc001vqo.2_Silent_p.N651N|LIG4_uc010agg.1_Silent_p.N584N|LIG4_uc010agf.2_Silent_p.N651N|LIG4_uc001vqp.2_Silent_p.N651N	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	651					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TTTTGTTAACGTTAGTAAGGT	0.373								NHEJ					12	148					0	0	0	0	A	108861664	A	A	108861664	2	1	65	1	0	0	0	0	0	0	0	1	8824	1136	40	1		1	LIG4	13	108861664	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	343354	108861664	6308214	391	13222											
ANKRD10	55608	broad.mit.edu	37	chr13	111563113	111563113	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccaactgcactaagcacTccaacttcgaaaacaagagg	16	6	6	13	1	1	1	1	0	0	1	3	2	2	1	2	1	5	2	2	1	6	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:111563113T>C	uc001vrn.2	-	2	350	c.215A>G	c.(214-216)GAG>GGG	p.E72G	ANKRD10_uc001vro.1_Missense_Mutation_p.E72G|ANKRD10_uc001vrp.1_Missense_Mutation_p.E72G	NM_017664	NP_060134	Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	72	ANK 2.									central_nervous_system(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			CACTAAGCACTCCAACTTCGA	0.478													4	48					0	0	0	0	C	111563113	C	C	111563113	3	2	65	1	0	0	0	0	1	0	0	0	638	1551	54	5	1067	5	ANKRD10	13	111563113	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	2701449	111563113	3606765	392	13223											
DCUN1D2	55208	broad.mit.edu	37	chr13	114115389	114115389	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattaagaatgtgttccagaGatctaaaaatttaaaccttc	16	13	5	7	0	1	2	0	0	1	2	3	3	2	2	2	0	1	1	2	0	7	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:114115389G>A	uc001vtr.1	-	5	622	c.583C>T	c.(583-585)CTC>TTC	p.L195F	DCUN1D2_uc001vts.1_RNA|DCUN1D2_uc010agw.1_Missense_Mutation_p.L62F	NM_001014283	NP_001014305	Q6PH85	DCNL2_HUMAN	DCN1, defective in cullin neddylation 1, domain	195	DCUN1.										0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.029)|GBM - Glioblastoma multiforme(44;0.234)			GTGTTCCAGAGATCTAAAAAT	0.418													8	59					0	0	0	0	A	114115389	A	A	114115389	3	1	65	1	0	0	0	0	1	0	0	0	4331	942	33	2	208	2	DCUN1D2	13	114115389	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2552276	114115389	1054489	393	13224											
ZNF828	283489	broad.mit.edu	37	chr13	115089332	115089332	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaagaatggaagcattccaGgaacttcgtaaaccatcagc	16	7	9	9	1	1	2	1	0	0	2	3	4	2	4	2	2	4	2	2	2	6	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr13:115089332G>A	uc010ahb.2	+	3	344	c.15G>A	c.(13-15)CAG>CAA	p.Q5Q	ZNF828_uc001vuv.2_Silent_p.Q5Q|ZNF828_uc010tko.1_Silent_p.Q5Q	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	5					attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		AAGCATTCCAGGAACTTCGTA	0.378													13	156					0	0	0	0	A	115089332	A	A	115089332	2	1	65	1	0	0	0	0	0	0	0	1	18248	991	35	4		4	ZNF828	13	115089332	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	973943	115089332	80546	394	13225											
NGDN	25983	broad.mit.edu	37	chr14	23945268	23945268	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggatgaggaggaagatgaaGcagaagatgaccagtctgag	16	5	16	4	0	1	7	0	4	1	3	1	10	1	10	1	3	1	1	1	3	3	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:23945268G>A	uc001wjy.2	+	7	478	c.451G>A	c.(451-453)GCA>ACA	p.A151T	NGDN_uc001wjz.2_Missense_Mutation_p.A151T|NGDN_uc001wka.2_5'Flank	NM_001042635	NP_001036100	Q8NEJ9	NGDN_HUMAN	neuroguidin isoform 1	151	Necessary for interaction with EIF4E (By similarity).				regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus					0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GGAAGATGAAGCAGAAGATGA	0.413													10	120					0	0	0	0	A	23945268	A	A	23945268	3	1	65	1	0	0	0	0	1	0	0	0	10447	971	34	4	477	4	NGDN	14	23945268	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08		23945268	83404272	395	13226											
CMA1	1215	broad.mit.edu	37	chr14	24975727	24975727	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgttatattttggatgaCggaattgctttataacctca	12	16	8	5	1	1	1	1	1	0	0	1	3	1	3	1	2	2	2	1	2	6	8	rs13306252	by1000genomes	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:24975727C>T	uc001wpp.1	-	3	323	c.293G>A	c.(292-294)CGT>CAT	p.R98H	CMA1_uc010alx.1_5'UTR	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	98	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		TTTTGGATGACGGAATTGCTT	0.423													23	189					0	0	0	0	T	24975727	T	T	24975727	3	4	65	1	0	0	0	0	1	0	0	0	3589	536	19	1	462	1	CMA1	14	24975727	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1030459	24975727	82373813	396	13227											
ARHGAP5	394	broad.mit.edu	37	chr14	32562761	32562761	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaatcaacccatcaaagtgaAgatgtttttctaccatctcc	13	12	5	11	0	4	2	2	1	2	1	5	3	4	2	3	0	2	1	3	0	5	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:32562761A>C	uc001wrl.2	+	2	3125	c.2886A>C	c.(2884-2886)GAA>GAC	p.E962D	ARHGAP5_uc001wrm.2_Missense_Mutation_p.E962D|ARHGAP5_uc001wrn.2_Missense_Mutation_p.E962D|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	962					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		ATCAAAGTGAAGATGTTTTTC	0.358													20	137					0	0	0	0	C	32562761	C	C	32562761	3	2	65	1	0	0	0	0	1	0	0	0	886	69	3	5	2888	5	ARHGAP5	14	32562761	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	7587034	32562761	74786779	397	13228											
AKAP6	9472	broad.mit.edu	37	chr14	33292499	33292499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgtcagtgatgagatgaaggGcagtaaagatataagtagca	16	9	13	3	0	1	4	1	3	0	2	1	5	1	4	0	1	1	4	0	1	6	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:33292499G>A	uc001wrq.2	+	13	5650	c.5480G>A	c.(5479-5481)GGC>GAC	p.G1827D		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1827					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GAGATGAAGGGCAGTAAAGAT	0.383													7	131					0	0	0	0	A	33292499	A	A	33292499	3	1	65	1	0	0	0	0	1	0	0	0	455	1203	42	4	5526	4	AKAP6	14	33292499	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	729738	33292499	74057041	398	13229											
CTAGE5	4253	broad.mit.edu	37	chr14	39782616	39782616	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaagtagatgaaaagatcagCcatgccactgaagagctgga	17	6	11	7	0	1	5	1	2	0	3	1	6	1	6	2	1	3	2	2	1	5	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:39782616C>A	uc001wvg.3	+	14	1602	c.1266C>A	c.(1264-1266)AGC>AGA	p.S422R	CTAGE5_uc010tqe.1_Missense_Mutation_p.S384R|CTAGE5_uc001wuz.3_Missense_Mutation_p.S410R|CTAGE5_uc001wuy.3_Missense_Mutation_p.S342R|CTAGE5_uc001wvb.3_Missense_Mutation_p.S393R|CTAGE5_uc001wvc.3_Missense_Mutation_p.S367R|CTAGE5_uc001wva.3_Missense_Mutation_p.S393R|CTAGE5_uc001wvh.3_Missense_Mutation_p.S422R|CTAGE5_uc001wvf.3_Missense_Mutation_p.S347R|CTAGE5_uc001wvi.3_Missense_Mutation_p.S427R|CTAGE5_uc010amz.2_Missense_Mutation_p.S38R|CTAGE5_uc001wvj.3_Missense_Mutation_p.S393R	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	422	Potential.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		AAAAGATCAGCCATGCCACTG	0.308													10	108					4.68919e-08	4.94926e-08	1	0	A	39782616	A	A	39782616	3	1	65	1	0	0	0	0	1	0	0	0	4011	738	26	4	1351	4	CTAGE5	14	39782616	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6490117	39782616	67566924	399	13230											
RPL10L	140801	broad.mit.edu	37	chr14	47120636	47120636	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccccagcacaggacaacaTcttgttgatgcggatgacat	12	8	10	11	1	1	2	0	2	1	0	1	4	1	4	2	2	4	2	2	2	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:47120636T>C	uc001wwg.2	-	1	393	c.304A>G	c.(304-306)ATG>GTG	p.M102V		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	102					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						CAGGACAACATCTTGTTGATG	0.527													13	95					0	0	0	0	C	47120636	C	C	47120636	3	2	65	1	0	0	0	0	1	0	0	0	13621	1435	50	5	344	5	RPL10L	14	47120636	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	7338020	47120636	60228904	400	13231											
ARF6	382	broad.mit.edu	37	chr14	50360887	50360887	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aactgggcctgacccggattCgggacaggaactggtatgtg	9	8	15	9	2	0	1	0	1	0	0	1	4	0	4	2	5	2	1	2	5	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:50360887C>G	uc001wxg.3	+	2	1054	c.433C>G	c.(433-435)CGG>GGG	p.R145G		NM_001663	NP_001654	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	145					cell adhesion|cellular component movement|cortical actin cytoskeleton organization|negative regulation of receptor-mediated endocytosis|positive regulation of actin filament polymerization|positive regulation of establishment of protein localization in plasma membrane|protein localization at cell surface|protein transport|regulation of dendritic spine development|regulation of filopodium assembly|regulation of Rac protein signal transduction|ruffle organization|small GTPase mediated signal transduction|vesicle-mediated transport	cell cortex|endosome membrane|filopodium membrane|Golgi apparatus|membrane fraction|ruffle	GTP binding|GTPase activity|thioesterase binding				0	all_epithelial(31;0.000822)|Breast(41;0.0117)					GACCCGGATTCGGGACAGGAA	0.552													8	62					0	0	0	0	G	50360887	G	G	50360887	3	3	65	1	0	0	0	0	1	0	0	0	848	875	31	3	435	3	ARF6	14	50360887	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3240251	50360887	56988653	401	13232											
NID2	22795	broad.mit.edu	37	chr14	52481919	52481919	+	Frame_Shift_Del	DEL	G	-	-																															gggcacgtactggtcatcccGgggggtgccaccgtagtgct																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:52481919delG	uc001wzo.2	-	15	3337	c.3103delC	c.(3103-3105)CGGfs	p.R1035fs	NID2_uc010tqs.1_Frame_Shift_Del_p.R987fs|NID2_uc010tqt.1_Frame_Shift_Del_p.R1035fs|NID2_uc001wzp.2_Frame_Shift_Del_p.R1035fs	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1035	Thyroglobulin type-1 2.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TGGTCATCCCGGGGGGTGCCA	0.622													---	---	---								-	52481919	-	-	52481919	7	5	65	1	0	1	0	1	0	0	0	0	10469	1115	39	0	1056	0	NID2	14	52481919	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	2121032	52481919	54867621	402	13233											
WDHD1	11169	broad.mit.edu	37	chr14	55453969	55453969	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctccaatagtaaacaatcGaagaagcagggcactagtag	16	6	9	10	1	0	1	0	0	0	1	2	2	1	1	2	1	2	4	2	1	9	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:55453969G>A	uc001xbm.1	-	14	1741	c.1663C>T	c.(1663-1665)CGA>TGA	p.R555*	WDHD1_uc010aom.1_Nonsense_Mutation_p.R72*|WDHD1_uc001xbn.1_Nonsense_Mutation_p.R432*	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	555						cytoplasm|nucleoplasm	DNA binding			skin(1)	1						GTAAACAATCGAAGAAGCAGG	0.458													8	96					0	0	0	0	A	55453969	A	A	55453969	4	1	65	1	0	0	0	0	0	1	0	0	17339	1066	37	1	1778	1	WDHD1	14	55453969	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2972050	55453969	51895571	403	13234											
C14orf101	54916	broad.mit.edu	37	chr14	57092099	57092099	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgtgtgacttttctggcaGatgatgacttacgagtggta	9	15	12	5	1	1	4	0	3	1	1	1	5	1	4	0	2	1	2	0	2	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:57092099G>C	uc001xcm.2	+	12	1521	c.1399_splice	c.e12-1	p.M467_splice	C14orf101_uc001xcj.2_Splice_Site|C14orf101_uc001xcl.1_Splice_Site|C14orf101_uc001xcn.2_Splice_Site|C14orf101_uc010trf.1_Splice_Site|C14orf101_uc001xco.2_Splice_Site	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916							integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		TTTTCTGGCAGATGATGACTT	0.323													8	150					0	0	0	0	C	57092099	C	C	57092099	5	2	65	1	0	0	0	0	0	0	1	0	1740	956	33	2	1444	2	C14orf101	14	57092099	Splice_Site	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1638130	57092099	50257441	404	13235											
MNAT1	4331	broad.mit.edu	37	chr14	61201668	61201668	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaatgtgtgcggacacactCtgtgagttgggcggcagtgg	7	10	17	7	2	1	2	0	2	1	0	1	3	1	3	0	4	1	2	0	4	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:61201668C>T	uc001xfd.2	+	1	199	c.88C>T	c.(88-90)CTC>TTC	p.L30F	MNAT1_uc010apq.1_Missense_Mutation_p.L30F|MNAT1_uc001xfe.2_Missense_Mutation_p.L30F	NM_002431	NP_002422	P51948	MAT1_HUMAN	menage a trois 1 (CAK assembly factor)	30	RING-type.				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein complex assembly|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cytoplasm|holo TFIIH complex	protein N-terminus binding|zinc ion binding			ovary(1)|lung(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.0174)		CGGACACACTCTGTGAGTTGG	0.602								Direct_reversal_of_damage|NER					6	76					0	0	0	0	T	61201668	T	T	61201668	3	4	65	1	0	0	0	0	1	0	0	0	9727	927	32	2	90	2	MNAT1	14	61201668	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4109569	61201668	46147872	405	13236											
KCNH5	27133	broad.mit.edu	37	chr14	63174448	63174448	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgtcctctttgagttcGtgtttgacttcctgcagtgt	4	18	11	8	1	1	2	0	2	1	0	4	3	3	3	2	1	1	3	2	1	0	4	rs138093802		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:63174448G>A	uc001xfx.2	-	11	2796	c.2745C>T	c.(2743-2745)CAC>CAT	p.H915H	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	915	CAD (involved in subunit assembly) (By similarity).|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CTTTGAGTTCGTGTTTGACTT	0.512													27	294					0	0	0	0	A	63174448	A	A	63174448	2	1	65	1	0	0	0	0	0	0	0	1	8074	1136	40	1		1	KCNH5	14	63174448	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1972780	63174448	44175092	406	13237											
KCNH5	27133	broad.mit.edu	37	chr14	63174587	63174587	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaaacgaaggtcactttttGtaattccactgtcacaagaa	14	11	6	10	1	2	1	2	0	0	1	3	2	3	1	2	1	1	1	2	1	5	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:63174587G>T	uc001xfx.2	-	11	2657	c.2606C>A	c.(2605-2607)ACA>AAA	p.T869K	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	869	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GTCACTTTTTGTAATTCCACT	0.498													14	188					1.05317e-09	1.13446e-09	1	0	T	63174587	T	T	63174587	3	4	65	1	0	0	0	0	1	0	0	0	8074	1377	48	4	364	4	KCNH5	14	63174587	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	139	63174587	44174953	407	13238											
ZFYVE26	23503	broad.mit.edu	37	chr14	68274151	68274151	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccctcggtggcttttctgTgaccttctctgcataggtat	5	15	10	11	1	2	1	0	1	2	0	4	1	2	1	2	3	2	3	2	3	2	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:68274151T>C	uc001xka.2	-	5	989	c.850A>G	c.(850-852)ACA>GCA	p.T284A	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.T284A|ZFYVE26_uc010tta.1_Missense_Mutation_p.T284A	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	284					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GGCTTTTCTGTGACCTTCTCT	0.597													9	48					0	0	0	0	C	68274151	C	C	68274151	3	2	65	1	0	0	0	0	1	0	0	0	17735	1696	59	5	6921	5	ZFYVE26	14	68274151	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	5099564	68274151	39075389	408	13239											
PCNX	22990	broad.mit.edu	37	chr14	71444229	71444229	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagtggaacggaccgggAcactaacagtactgtcagca	12	6	12	11	2	1	0	1	0	0	0	1	3	1	3	1	3	5	3	1	3	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:71444229A>T	uc001xmo.2	+	6	1621	c.1175A>T	c.(1174-1176)GAC>GTC	p.D392V	PCNX_uc001xmn.3_Missense_Mutation_p.D392V|PCNX_uc010are.1_Missense_Mutation_p.D392V	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	392						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		ACGGACCGGGACACTAACAGT	0.498													10	109					0	0	0	0	T	71444229	T	T	71444229	3	4	65	1	0	0	0	0	1	0	0	0	11645	275	10	5	1197	5	PCNX	14	71444229	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	3170078	71444229	35905311	409	13240											
FAM161B	145483	broad.mit.edu	37	chr14	74411111	74411111	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggccttctgcttggagatCttggcttcagctgtggctgc	3	14	14	10	0	3	1	1	0	2	1	3	2	3	1	1	4	3	4	1	4	0	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:74411111C>G	uc001xpd.1	-	3	958	c.852G>C	c.(850-852)AAG>AAC	p.K284N		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						GCTTGGAGATCTTGGCTTCAG	0.542													17	201					0	0	0	0	G	74411111	G	G	74411111	3	3	65	1	0	0	0	0	1	0	0	0	5501	912	32	2	1119	2	FAM161B	14	74411111	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2966882	74411111	32938429	410	13241											
FAM161B	145483	broad.mit.edu	37	chr14	74411195	74411195	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaggaagctgaagggcttCaaagaagagaggagcagttc	14	6	14	7	0	1	3	1	1	0	2	3	6	2	5	1	3	2	4	1	3	4	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:74411195C>T	uc001xpd.1	-	3	874	c.768G>A	c.(766-768)TTG>TTA	p.L256L		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						TGAAGGGCTTCAAAGAAGAGA	0.562													8	128					0	0	0	0	T	74411195	T	T	74411195	2	4	65	1	0	0	0	0	0	0	0	1	5501	825	29	2		2	FAM161B	14	74411195	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	84	74411195	32938345	411	13242											
TSHR	7253	broad.mit.edu	37	chr14	81610460	81610460	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttcaccaaggccttccaGagggatgtgttcatcctact	9	13	8	11	0	2	1	2	0	0	1	4	2	4	2	4	2	1	1	4	2	2	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:81610460G>A	uc001xvd.1	+	10	2214	c.2058G>A	c.(2056-2058)CAG>CAA	p.Q686Q		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	686	Cytoplasmic (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	AGGCCTTCCAGAGGGATGTGT	0.478			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						28	228					0	0	0	0	A	81610460	A	A	81610460	2	1	65	1	0	0	0	0	0	0	0	1	16689	933	33	2		2	TSHR	14	81610460	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	7199265	81610460	25739080	412	13243											
TTC7B	145567	broad.mit.edu	37	chr14	91044465	91044465	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaccagtcgctgcatgctCttcacgtgggtggggctgat	5	11	13	12	2	3	1	2	1	1	0	4	1	3	1	1	3	2	4	1	3	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:91044465C>G	uc001xyp.2	-	19	2417	c.2295G>C	c.(2293-2295)AAG>AAC	p.K765N	TTC7B_uc001xyo.2_Missense_Mutation_p.K209N|TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	765	TPR 10.						binding			ovary(2)	2		Melanoma(154;0.222)				GCTGCATGCTCTTCACGTGGG	0.647													4	16					0	0	0	0	G	91044465	G	G	91044465	3	3	65	1	0	0	0	0	1	0	0	0	16781	912	32	2	244	2	TTC7B	14	91044465	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	9434005	91044465	16305075	413	13244											
PRIMA1	145270	broad.mit.edu	37	chr14	94187823	94187823	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgttcacgtctactcctttGttgctctgcgaagcactcat	6	16	7	12	2	4	0	2	0	2	0	5	1	5	0	1	0	4	4	1	0	2	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:94187823G>A	uc001ybw.1	-	5	471	c.429C>T	c.(427-429)AAC>AAT	p.N143N	PRIMA1_uc001ybx.1_RNA	NM_178013	NP_821092	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1 precursor	143	Cytoplasmic (Potential).				neurotransmitter catabolic process	cell junction|integral to membrane|synapse				large_intestine(1)|skin(1)	2		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		CTACTCCTTTGTTGCTCTGCG	0.572													5	75					0	0	0	0	A	94187823	A	A	94187823	2	1	65	1	0	0	0	0	0	0	0	1	12554	1368	48	4		4	PRIMA1	14	94187823	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3143358	94187823	13161717	414	13245											
CLMN	79789	broad.mit.edu	37	chr14	95670573	95670573	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcggtggagctgtctgacagCgcatggctggaaacaccatc	9	8	13	11	2	1	1	0	1	1	0	3	3	1	3	1	4	3	3	1	4	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:95670573C>T	uc001yef.2	-	9	1229	c.1113G>A	c.(1111-1113)GCG>GCA	p.A371A		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	371						integral to membrane	actin binding				0				Epithelial(152;0.193)		TGTCTGACAGCGCATGGCTGG	0.542													19	140					0	0	0	0	T	95670573	T	T	95670573	2	4	65	1	0	0	0	0	0	0	0	1	3557	755	27	1		1	CLMN	14	95670573	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1482750	95670573	11678967	415	13246											
EIF5	1983	broad.mit.edu	37	chr14	103805991	103805991	+	Frame_Shift_Del	DEL	A	-	-																															tgcagttttgtcacaacaacAaaaaagcccaacggtacctt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr14:103805991delA	uc001ymq.2	+	10	1444	c.922delA	c.(922-924)AAAfs	p.K308fs	EIF5_uc001ymr.2_Frame_Shift_Del_p.K308fs|EIF5_uc001yms.2_Frame_Shift_Del_p.K308fs|EIF5_uc001ymt.2_Frame_Shift_Del_p.K308fs|EIF5_uc001ymu.2_Frame_Shift_Del_p.K308fs	NM_001969	NP_001960	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	308	W2.				regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			pancreas(1)|breast(1)|skin(1)	3		Melanoma(154;0.155)	Epithelial(46;0.182)			TCACAACAACAAAAAAGCCCA	0.388													---	---	---								-	103805991	-	-	103805991	7	5	65	1	0	1	0	1	0	0	0	0	5064	131	5	0	952	0	EIF5	14	103805991	Frame_Shift_Del	DEL	A	TCGA-CN-5369-01A-01D-1434-08	8135418	103805991	3543549	416	13247											
ATP10A	57194	broad.mit.edu	37	chr15	25925395	25925395	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcacaagacgcattgtaaaTcaaagccacggtgaaaaaca	18	5	9	9	2	1	2	1	1	0	1	1	2	1	2	1	2	2	3	1	2	6	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:25925395T>A	uc010ayu.2	-	20	3845	c.3739A>T	c.(3739-3741)ATT>TTT	p.I1247F		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1247	Helical; (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCATTGTAAATCAAAGCCACG	0.478													14	141					0	0	0	0	A	25925395	A	A	25925395	3	1	65	1	0	0	0	0	1	0	0	0	1118	1435	50	5	768	5	ATP10A	15	25925395	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08		25925395	76605997	417	13248											
C15orf55	256646	broad.mit.edu	37	chr15	34648388	34648388	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagaggtacccccatggctCagagttatgatcagaatcct	12	9	9	11	0	2	4	2	1	0	3	3	4	3	4	3	2	1	3	3	2	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:34648388C>G	uc001zif.2	+	7	2250	c.2095C>G	c.(2095-2097)CAG>GAG	p.Q699E	C15orf55_uc010ucc.1_Missense_Mutation_p.Q727E|C15orf55_uc010ucd.1_Missense_Mutation_p.Q717E	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	699						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CCCCATGGCTCAGAGTTATGA	0.572			T	BRD3|BRD4	lethal midline carcinoma								6	82					0	0	0	0	G	34648388	G	G	34648388	3	3	65	1	0	0	0	0	1	0	0	0	1809	827	29	2	2121	2	C15orf55	15	34648388	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	8722993	34648388	67883004	418	13249											
MAPKBP1	23005	broad.mit.edu	37	chr15	42104154	42104154	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagttcttgcctccctgcaGagtgggcacatgcctgccgt	5	10	11	15	1	1	1	0	0	1	1	2	1	2	1	5	1	4	3	5	1	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:42104154G>A	uc001zok.3	+	6	614	c.328_splice	c.e6-1	p.S110_splice	MAPKBP1_uc001zoj.3_Splice_Site_p.S110_splice|MAPKBP1_uc010bcj.2_Splice_Site|MAPKBP1_uc010bci.2_Splice_Site_p.S110_splice|MAPKBP1_uc010udb.1_Splice_Site|MAPKBP1_uc010bck.2_Splice_Site|MAPKBP1_uc010bcl.2_5'Flank	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein											central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CCTCCCTGCAGAGTGGGCACA	0.607											OREG0023077	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	91					0	0	0	0	A	42104154	A	A	42104154	5	1	65	1	0	0	0	0	0	0	1	0	9345	956	33	2	345	2	MAPKBP1	15	42104154	Splice_Site	SNP	G	TCGA-CN-5369-01A-01D-1434-08	7455766	42104154	60427238	419	13250											
EHD4	30844	broad.mit.edu	37	chr15	42211429	42211429	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggccagcctcgctcgcttGatgaggtcgttgagcttgcg	4	12	14	11	4	0	3	0	3	0	0	3	3	0	3	2	2	3	4	2	2	0	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:42211429G>C	uc001zot.2	-	4	966	c.903C>G	c.(901-903)ATC>ATG	p.I301M		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	301					endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		TCGCTCGCTTGATGAGGTCGT	0.632													6	98					0	0	0	0	C	42211429	C	C	42211429	3	2	65	1	0	0	0	0	1	0	0	0	5002	1280	45	2	734	2	EHD4	15	42211429	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	107275	42211429	60319963	420	13251											
CDAN1	146059	broad.mit.edu	37	chr15	43021249	43021249	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgacacagtttgatccaaTtctttctgccacgaactcta	10	15	5	11	1	3	2	0	2	3	0	4	3	4	2	2	0	2	1	2	0	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:43021249T>G	uc001zql.2	-	19	2734	c.2617A>C	c.(2617-2619)ATT>CTT	p.I873L	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Missense_Mutation_p.I199L	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	873						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		TTTGATCCAATTCTTTCTGCC	0.532													11	152					0	0	0	0	G	43021249	G	G	43021249	3	3	65	1	0	0	0	0	1	0	0	0	3069	1493	52	5	1106	5	CDAN1	15	43021249	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	809820	43021249	59510143	421	13252											
TP53BP1	7158	broad.mit.edu	37	chr15	43720272	43720272	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatacacatctgtaatgacaCgagtgacaagtgtgcgtact	14	10	9	8	2	1	2	0	2	1	0	1	3	1	2	0	0	3	2	0	0	5	3	rs144680391	by1000genomes	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:43720272C>T	uc001zrs.2	-	18	3903	c.3755G>A	c.(3754-3756)CGT>CAT	p.R1252H	TP53BP1_uc010udp.1_Missense_Mutation_p.R1252H|TP53BP1_uc001zrq.3_Missense_Mutation_p.R1257H|TP53BP1_uc001zrr.3_Missense_Mutation_p.R1257H|TP53BP1_uc010udq.1_Missense_Mutation_p.R1257H	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1252					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TGTAATGACACGAGTGACAAG	0.408								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					22	256					0	0	0	0	T	43720272	T	T	43720272	3	4	65	1	0	0	0	0	1	0	0	0	16450	536	19	1	2207	1	TP53BP1	15	43720272	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	699023	43720272	58811120	422	13253											
CATSPER2	117155	broad.mit.edu	37	chr15	43940128	43940128	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgaccaagtaactccctGatagtgtgccgcggcacagc	9	8	11	13	2	0	2	0	2	0	0	1	2	1	2	3	1	4	3	3	1	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:43940128G>A	uc001zsh.2	-	2	347	c.132C>T	c.(130-132)ATC>ATT	p.I44I	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Silent_p.I44I|CATSPER2_uc001zsj.2_Silent_p.I44I|CATSPER2_uc001zsk.2_Silent_p.I44I|CATSPER2_uc001zsl.1_Intron	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	44	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GTAACTCCCTGATAGTGTGCC	0.453													13	210					0	0	0	0	A	43940128	A	A	43940128	2	1	65	1	0	0	0	0	0	0	0	1	2700	1280	45	2		2	CATSPER2	15	43940128	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	219856	43940128	58591264	423	13254											
SQRDL	58472	broad.mit.edu	37	chr15	45981265	45981265	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacacatcatgtccactggTgaccggctacaaccgtgtga	10	9	9	13	2	1	2	1	2	0	0	2	2	2	2	3	2	3	1	3	2	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:45981265T>C	uc001zvt.2	+	10	1334	c.1145T>C	c.(1144-1146)GTG>GCG	p.V382A	SQRDL_uc001zvu.2_Missense_Mutation_p.V382A|SQRDL_uc001zvv.2_Missense_Mutation_p.V382A	NM_021199	NP_067022	Q9Y6N5	SQRD_HUMAN	sulfide dehydrogenase like precursor	382							oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		TGTCCACTGGTGACCGGCTAC	0.393													33	307					0	0	0	0	C	45981265	C	C	45981265	3	2	65	1	0	0	0	0	1	0	0	0	15195	1696	59	5	1175	5	SQRDL	15	45981265	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	2041137	45981265	56550127	424	13255											
AP4E1	23431	broad.mit.edu	37	chr15	51221216	51221216	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtcttcagggagattgtaCgaagaaaagctgttctggca	11	12	12	6	1	3	2	1	0	2	2	3	4	3	2	0	2	2	4	0	2	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:51221216C>T	uc001zyx.1	+	6	583	c.553C>T	c.(553-555)CGA>TGA	p.R185*	AP4E1_uc010ufi.1_Nonsense_Mutation_p.R185*|AP4E1_uc010ufj.1_RNA|AP4E1_uc010ufk.1_RNA	NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	185					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		GGAGATTGTACGAAGAAAAGC	0.318													6	90					0	0	0	0	T	51221216	T	T	51221216	4	4	65	1	0	0	0	0	0	1	0	0	752	528	19	1	575	1	AP4E1	15	51221216	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	5239951	51221216	51310176	425	13256											
HERC1	8925	broad.mit.edu	37	chr15	64017534	64017534	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaccgtcactgaacagtggCgttttcatccaatatgcagt	11	11	8	11	2	2	1	2	1	0	0	3	1	3	1	2	1	2	2	2	1	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:64017534C>T	uc002amp.2	-	18	3673	c.3525G>A	c.(3523-3525)ACG>ACA	p.T1175T	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1175					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TGAACAGTGGCGTTTTCATCC	0.473													8	63					0	0	0	0	T	64017534	T	T	64017534	2	4	65	1	0	0	0	0	0	0	0	1	7096	755	27	1		1	HERC1	15	64017534	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	12796318	64017534	38513858	426	13257											
ZNF609	23060	broad.mit.edu	37	chr15	64792307	64792307	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatcctttgggaactaaacCggagccagaggaaggggaga	14	5	14	8	1	0	2	0	0	0	2	1	6	1	5	3	5	3	0	3	5	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:64792307C>T	uc002ann.2	+	1	689	c.689C>T	c.(688-690)CCG>CTG	p.P230L	ZNF609_uc010bgy.2_Missense_Mutation_p.P230L	NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	230						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GGAACTAAACCGGAGCCAGAG	0.532													8	60					0	0	0	0	T	64792307	T	T	64792307	3	4	65	1	0	0	0	0	1	0	0	0	18102	652	23	1	691	1	ZNF609	15	64792307	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	774773	64792307	37739085	427	13258											
KBTBD13	390594	broad.mit.edu	37	chr15	65370407	65370407	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctctacgccatcgagggCggcacctggcggctgctcag	5	7	14	15	4	2	0	1	0	1	0	3	1	2	0	2	4	3	4	2	4	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:65370407C>T	uc010uis.1	+	1	1254	c.1254C>T	c.(1252-1254)GGC>GGT	p.G418G	RASL12_uc010uir.1_5'Flank	NM_001101362	NP_001094832	C9JR72	KBTBD_HUMAN	hypothetical protein LOC390594	418						cytoplasm					0						CCATCGAGGGCGGCACCTGGC	0.652													5	13					0	0	0	0	T	65370407	T	T	65370407	2	4	65	1	0	0	0	0	0	0	0	1	8031	755	27	1		1	KBTBD13	15	65370407	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	578100	65370407	37160985	428	13259											
ISLR	3671	broad.mit.edu	37	chr15	74468208	74468208	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaatgagctgggcagtgctGagagctcagtggacgtggca	9	7	16	9	1	1	2	1	2	0	1	1	4	1	3	1	3	3	5	1	3	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:74468208G>A	uc002axg.1	+	2	1291	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	ISLR_uc002axh.1_Missense_Mutation_p.E337K	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	337	Ig-like.				cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						GGGCAGTGCTGAGAGCTCAGT	0.622													4	39					0	0	0	0	A	74468208	A	A	74468208	3	1	65	1	0	0	0	0	1	0	0	0	7897	1291	45	2	1011	2	ISLR	15	74468208	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	9097801	74468208	28063184	429	13260											
SIN3A	25942	broad.mit.edu	37	chr15	75702243	75702243	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccattctggctgggcctctgCggcttgttgttcagttgggg	2	14	15	10	1	3	0	1	0	2	0	3	0	3	0	2	5	1	5	2	5	0	5	rs142678572	byFrequency	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:75702243C>T	uc002bai.2	-	8	1510	c.1251G>A	c.(1249-1251)CCG>CCA	p.P417P	SIN3A_uc002baj.2_Silent_p.P417P|SIN3A_uc010uml.1_Silent_p.P417P	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	417	Interaction with REST (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						TGGGCCTCTGCGGCTTGTTGT	0.498													15	139					0	0	0	0	T	75702243	T	T	75702243	2	4	65	1	0	0	0	0	0	0	0	1	14390	755	27	1		1	SIN3A	15	75702243	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1234035	75702243	26829149	430	13261											
RASGRF1	5923	broad.mit.edu	37	chr15	79327554	79327554	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaaacatgatggtttcgcTgaaagagaaagcacagggtc	16	8	11	6	1	0	3	0	2	0	1	2	4	0	3	0	2	2	3	0	2	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:79327554T>C	uc002beq.2	-	6	1254	c.879_splice	c.e6-1	p.S293_splice	RASGRF1_uc002bep.2_Splice_Site_p.S293_splice|RASGRF1_uc010blm.1_Splice_Site_p.S215_splice|RASGRF1_uc002ber.3_Splice_Site_p.S293_splice	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine						activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						ATGGTTTCGCTGAAAGAGAAA	0.562													3	16					0	0	0	0	C	79327554	C	C	79327554	5	2	65	1	0	0	0	0	0	0	1	0	13137	1594	55	5	3036	5	RASGRF1	15	79327554	Splice_Site	SNP	T	TCGA-CN-5369-01A-01D-1434-08	3625311	79327554	23203838	431	13262											
FSD2	123722	broad.mit.edu	37	chr15	83456014	83456014	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcttggactactttcctCatcctagtgttctcttctgg	5	17	7	12	0	4	0	2	0	2	0	7	1	6	1	2	2	2	2	2	2	2	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:83456014C>A	uc002bjd.2	-	2	296	c.129G>T	c.(127-129)ATG>ATT	p.M43I	FSD2_uc010uol.1_Missense_Mutation_p.M43I|FSD2_uc010uom.1_Missense_Mutation_p.M43I	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	43										central_nervous_system(1)	1						CTACTTTCCTCATCCTAGTGT	0.483													23	231					8.24728e-16	9.10245e-16	1	0	A	83456014	A	A	83456014	3	1	65	1	0	0	0	0	1	0	0	0	6105	826	29	2	2168	2	FSD2	15	83456014	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4128460	83456014	19075378	432	13263											
C15orf40	123207	broad.mit.edu	37	chr15	83679041	83679041	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcatggatggctatggtgacGcatcctttaggatcaactgc	9	11	12	9	1	1	1	1	1	0	0	2	3	2	3	1	4	2	3	1	4	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:83679041G>A	uc010uoo.1	-	2	220	c.186C>T	c.(184-186)TGC>TGT	p.C62C	C15orf40_uc010uon.1_Silent_p.C62C|C15orf40_uc002bjm.2_Silent_p.C62C|C15orf40_uc010uop.1_Silent_p.C62C|C15orf40_uc010uoq.1_RNA|C15orf40_uc010uor.1_Silent_p.C62C	NM_001160115	NP_001153587	Q8WUR7	CO040_HUMAN	hypothetical protein LOC123207 isoform d	35										skin(1)	1						CTATGGTGACGCATCCTTTAG	0.483													26	220					0	0	0	0	A	83679041	A	A	83679041	2	1	65	1	0	0	0	0	0	0	0	1	1800	1079	38	1		1	C15orf40	15	83679041	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	223027	83679041	18852351	433	13264											
BTBD1	53339	broad.mit.edu	37	chr15	83698895	83698895	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atataacagatacctgattcGatcactcgtcccactgtaac	13	11	5	12	2	1	2	1	1	0	1	4	3	2	2	2	0	3	1	2	0	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:83698895G>A	uc002bjn.2	-	5	1251	c.1048C>T	c.(1048-1050)CGA>TGA	p.R350*	BTBD1_uc002bjo.2_Nonsense_Mutation_p.R350*	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	350						cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		TACCTGATTCGATCACTCGTC	0.448													73	687					0	0	0	0	A	83698895	A	A	83698895	4	1	65	1	0	0	0	0	0	1	0	0	1542	1066	37	1	416	1	BTBD1	15	83698895	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	19854	83698895	18832497	434	13265											
TM6SF1	53346	broad.mit.edu	37	chr15	83805312	83805312	+	Frame_Shift_Del	DEL	T	-	-																															ccctgaagaagcaaaaatccTttttttagcattaaacatag																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:83805312delT	uc002bjp.2	+	10	1110	c.1001delT	c.(1000-1002)CTTfs	p.L334fs	TM6SF1_uc010bmq.2_Frame_Shift_Del_p.L303fs|TM6SF1_uc002bjq.2_3'UTR|TM6SF1_uc010bmr.2_RNA|TM6SF1_uc002bjr.2_Frame_Shift_Del_p.L186fs	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	334	Helical; (Potential).					integral to membrane				ovary(1)	1						GCAAAAATCCTTTTTTTAGCA	0.368													---	---	---								-	83805312	-	-	83805312	7	5	65	1	0	1	0	1	0	0	0	0	16038	1609	56	0	1039	0	TM6SF1	15	83805312	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	106417	83805312	18726080	435	13266											
MESP2	145873	broad.mit.edu	37	chr15	90321331	90321331	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagagccctgtctgtcgctGggagctccatctctcctgcc	4	10	10	17	1	2	1	0	0	2	1	6	2	4	2	5	1	3	2	5	1	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:90321331G>A	uc002bon.2	+	2	960	c.960G>A	c.(958-960)CTG>CTA	p.L320L	MESP2_uc010uqa.1_Silent_p.L22L	NM_001039958	NP_001035047	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog	320					Notch signaling pathway	nucleus	DNA binding				0	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			GTCTGTCGCTGGGAGCTCCAT	0.592													6	91					0	0	0	0	A	90321331	A	A	90321331	2	1	65	1	0	0	0	0	0	0	0	1	9536	1335	47	4		4	MESP2	15	90321331	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6516019	90321331	12210061	436	13267											
ZNF710	374655	broad.mit.edu	37	chr15	90611533	90611533	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacttctgcggccgcggcttCgcctaccccagcgagctcaa	6	7	10	18	5	2	0	1	0	1	0	3	1	2	0	4	2	4	2	4	2	2	3	rs144375764		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:90611533C>T	uc002bov.1	+	2	1287	c.1164C>T	c.(1162-1164)TTC>TTT	p.F388F		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	388	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			GCCGCGGCTTCGCCTACCCCA	0.642													11	56					0	0	0	0	T	90611533	T	T	90611533	2	4	65	1	0	0	0	0	0	0	0	1	18182	883	31	1		1	ZNF710	15	90611533	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	290202	90611533	11919859	437	13268											
C15orf58	390637	broad.mit.edu	37	chr15	90784558	90784558	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtcctcttccgtttgcacCgggagcctgatctccctggg	5	11	11	14	2	2	1	0	1	2	0	5	2	4	2	5	2	2	2	5	2	1	2	rs147221532	by1000genomes	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr15:90784558C>A	uc002bpc.2	+	4	597	c.418C>A	c.(418-420)CGG>AGG	p.R140R		NM_001013657	NP_001013679	Q6ZNW5	VTC2_HUMAN	hypothetical protein LOC390637	140					glucose metabolic process	cytoplasm	GDP-D-glucose phosphorylase activity				0						CCGTTTGCACCGGGAGCCTGA	0.602													13	147					3.27435e-08	3.47347e-08	1	0	A	90784558	A	A	90784558	2	1	65	1	0	0	0	0	0	0	0	1	1812	643	23	3		3	C15orf58	15	90784558	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	173025	90784558	11746834	438	13269											
IFT140	9742	broad.mit.edu	37	chr16	1652541	1652541	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgcgtcgggtgccagcacaGggaagcaacccggaacggcc	9	2	15	15	5	0	0	0	0	0	0	1	2	0	2	4	4	5	2	4	4	3	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:1652541G>A	uc002cmb.2	-	4	561	c.199C>T	c.(199-201)CTG>TTG	p.L67L		NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	67	WD 2.									ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				TGCCAGCACAGGGAAGCAACC	0.602													7	80					0	0	0	0	A	1652541	A	A	1652541	2	1	65	1	0	0	0	0	0	0	0	1	7595	991	35	4		4	IFT140	16	1652541	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08		1652541	88702212	439	13270											
TRAF7	84231	broad.mit.edu	37	chr16	2226122	2226122	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcaccgtgtatgccctggcgGtcatctcgacgccagaccag	7	7	12	15	4	2	1	1	0	1	1	3	2	2	1	4	2	1	2	4	2	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:2226122G>T	uc002cow.2	+	19	1918	c.1819G>T	c.(1819-1821)GTC>TTC	p.V607F		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	607	WD 6.				activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						TGCCCTGGCGGTCATCTCGAC	0.657													5	43					0.00116845	0.00118543	1	0	T	2226122	T	T	2226122	3	4	65	1	0	0	0	0	1	0	0	0	16513	1261	44	4	1889	4	TRAF7	16	2226122	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	573581	2226122	88128631	440	13271											
E4F1	1877	broad.mit.edu	37	chr16	2283182	2283182	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatgaaagccctggccccaGaggtgggggcgacggggggc	7	3	20	11	2	0	2	0	1	0	1	0	3	0	2	3	7	1	1	3	7	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:2283182G>T	uc002cpm.2	+	7	1102	c.1054G>T	c.(1054-1056)GAG>TAG	p.E352*	E4F1_uc010bsi.2_Nonsense_Mutation_p.E352*|E4F1_uc010bsj.2_Nonsense_Mutation_p.E352*	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	352					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						CCTGGCCCCAGAGGTGGGGGC	0.652													11	133					0.000673444	0.000684341	1	0	T	2283182	T	T	2283182	4	4	65	1	0	0	0	0	0	1	0	0	4896	943	33	2	1080	2	E4F1	16	2283182	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	57060	2283182	88071571	441	13272											
C16orf59	80178	broad.mit.edu	37	chr16	2514053	2514053	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacagcggtggcggaacaGccaccaagaccatgtcctgt	11	5	11	14	2	0	1	0	0	0	1	1	2	1	2	4	3	3	0	4	3	2	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:2514053G>T	uc002cqh.2	+	9	1009	c.978G>T	c.(976-978)CAG>CAT	p.Q326H	C16orf59_uc002cqf.1_Missense_Mutation_p.Q326H|C16orf59_uc002cqg.1_Missense_Mutation_p.Q159H|C16orf59_uc002cqi.2_Missense_Mutation_p.Q159H|C16orf59_uc010uwb.1_Intron	NM_025108	NP_079384	Q7L2K0	CP059_HUMAN	hypothetical protein LOC80178	326											0		Ovarian(90;0.17)				TGGCGGAACAGCCACCAAGAC	0.667													7	34					8.12818e-05	8.32708e-05	1	0	T	2514053	T	T	2514053	3	4	65	1	0	0	0	0	1	0	0	0	1829	962	34	4	1012	4	C16orf59	16	2514053	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	230871	2514053	87840700	442	13273											
ZG16B	124220	broad.mit.edu	37	chr16	2880712	2880712	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagagatgtatggccctggaGgaggcaagtatttcagcacc	11	8	13	9	0	1	1	1	0	0	1	1	4	1	3	2	4	1	4	2	4	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:2880712G>T	uc002cru.2	+	3	254	c.178G>T	c.(178-180)GGA>TGA	p.G60*		NM_145252	NP_660295	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16 homolog B precursor	60						extracellular region	sugar binding			ovary(1)	1						TGGCCCTGGAGGAGGCAAGTA	0.532													22	294					5.61819e-17	6.21166e-17	1	0	T	2880712	T	T	2880712	4	4	65	1	0	0	0	0	0	1	0	0	17739	1001	35	4	188	4	ZG16B	16	2880712	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	366659	2880712	87474041	443	13274											
PPL	5493	broad.mit.edu	37	chr16	4944500	4944500	+	Frame_Shift_Del	DEL	G	-	-																															gccagggcctcagggtctgtGggggggatcacaaaacacac																								rs147027769		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:4944500delG	uc002cyd.1	-	12	1452	c.1362delC	c.(1360-1362)CCCfs	p.P454fs		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	454	Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						CAGGGTCTGTGGGGGGGATCA	0.612													---	---	---								-	4944500	-	-	4944500	7	5	65	1	0	1	0	1	0	0	0	0	12394	1335	47	0	3952	0	PPL	16	4944500	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	2063788	4944500	85410253	444	13275											
PPL	5493	broad.mit.edu	37	chr16	4945273	4945273	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccacgcacctgctccccctCaaagtcacagagtgcctcca	9	6	6	20	1	2	1	2	0	0	1	4	1	4	1	6	0	2	2	6	0	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:4945273C>G	uc002cyd.1	-	11	1321	c.1231G>C	c.(1231-1233)GAG>CAG	p.E411Q		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	411	Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TGCTCCCCCTCAAAGTCACAG	0.502													5	67					0	0	0	0	G	4945273	G	G	4945273	3	3	65	1	0	0	0	0	1	0	0	0	12394	835	29	2	4087	2	PPL	16	4945273	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	773	4945273	85409480	445	13276											
PPL	5493	broad.mit.edu	37	chr16	4945622	4945622	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccgcagcagcagctcaatCtggtaccggtccttgaagtc	8	9	10	14	2	2	1	1	1	1	0	5	1	4	1	3	2	4	5	3	2	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:4945622C>A	uc002cyd.1	-	10	1158	c.1068G>T	c.(1066-1068)CAG>CAT	p.Q356H		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	356	Potential.|Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						GCAGCTCAATCTGGTACCGGT	0.642													18	118					5.35267e-07	5.61181e-07	1	0	A	4945622	A	A	4945622	3	1	65	1	0	0	0	0	1	0	0	0	12394	912	32	2	4254	2	PPL	16	4945622	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	349	4945622	85409131	446	13277											
PARN	5073	broad.mit.edu	37	chr16	14540819	14540819	+	Frame_Shift_Del	DEL	C	-	-																															cctctgagaggggctctgcaCaggaatcggtctgctcaagc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:14540819delC	uc010uzd.1	-	23	1932	c.1790delG	c.(1789-1791)TGTfs	p.C597fs	PARN_uc010uzc.1_Frame_Shift_Del_p.C536fs|PARN_uc010uze.1_Frame_Shift_Del_p.C551fs|PARN_uc010uzf.1_Frame_Shift_Del_p.C422fs	NM_002582	NP_002573	O95453	PARN_HUMAN	poly(A)-specific ribonuclease (deadenylation	597					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2						GGGCTCTGCACAGGAATCGGT	0.488													---	---	---								-	14540819	-	-	14540819	7	5	65	1	0	1	0	1	0	0	0	0	11507	478	17	0	137	0	PARN	16	14540819	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	9595197	14540819	75813934	447	13278											
ABCC1	4363	broad.mit.edu	37	chr16	16103674	16103674	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcgtctgctgggcagacctCttctactctttctgggaaag	7	13	10	11	1	5	1	0	0	5	1	6	2	5	2	1	2	2	2	1	2	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:16103674C>G	uc010bvi.2	+	3	442	c.267C>G	c.(265-267)CTC>CTG	p.L89L	ABCC1_uc010bvj.2_Silent_p.L89L|ABCC1_uc010bvk.2_Silent_p.L89L|ABCC1_uc010bvl.2_Silent_p.L89L|ABCC1_uc010bvm.2_Silent_p.L89L|ABCC1_uc002del.3_5'UTR	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	89	Helical; Name=2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGGCAGACCTCTTCTACTCTT	0.552													26	312					0	0	0	0	G	16103674	G	G	16103674	2	3	65	1	0	0	0	0	0	0	0	1	49	900	32	2		2	ABCC1	16	16103674	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1562855	16103674	74251079	448	13279											
GTF3C1	2975	broad.mit.edu	37	chr16	27539953	27539953	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caaggtccacattcagggtgGatctcttgcaagcgaagaga	12	8	12	9	1	2	1	1	0	1	1	4	4	3	2	1	3	2	1	1	3	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:27539953G>A	uc002dov.1	-	6	979	c.939C>T	c.(937-939)ATC>ATT	p.I313I	GTF3C1_uc002dou.2_Silent_p.I313I	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	313						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						ATTCAGGGTGGATCTCTTGCA	0.507													17	206					0	0	0	0	A	27539953	A	A	27539953	2	1	65	1	0	0	0	0	0	0	0	1	6911	1164	41	2		2	GTF3C1	16	27539953	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	11436279	27539953	62814800	449	13280											
SETD1A	9739	broad.mit.edu	37	chr16	30974857	30974857	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgagaagttccaaggctcGggtgcagccactgagacggt	10	7	15	9	2	0	2	0	2	0	2	2	4	1	2	2	3	2	3	2	3	2	1	rs141357385	byFrequency	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:30974857G>A	uc002ead.1	+	5	1307	c.621G>A	c.(619-621)TCG>TCA	p.S207S	SETD1A_uc002eae.1_Silent_p.S207S	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						TCCAAGGCTCGGGTGCAGCCA	0.572													13	81					0	0	0	0	A	30974857	A	A	30974857	2	1	65	1	0	0	0	0	0	0	0	1	14195	1103	39	1		1	SETD1A	16	30974857	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3434904	30974857	59379896	450	13281											
VPS35	55737	broad.mit.edu	37	chr16	46712964	46712964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttctcttttttctctatctCggctatgtccctgatgctgc	3	19	7	12	1	3	1	0	1	3	0	7	1	4	1	1	1	2	3	1	1	2	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:46712964C>T	uc002eef.3	-	6	710	c.611G>A	c.(610-612)CGA>CAA	p.R204Q	VPS35_uc002eed.2_Missense_Mutation_p.R25Q|VPS35_uc002eee.2_Missense_Mutation_p.R165Q	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	204					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TTCTCTATCTCGGCTATGTCC	0.433													14	121					0	0	0	0	T	46712964	T	T	46712964	3	4	65	1	0	0	0	0	1	0	0	0	17271	884	31	1	1827	1	VPS35	16	46712964	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	15738107	46712964	43641789	451	13282											
ZNF423	23090	broad.mit.edu	37	chr16	49672194	49672194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actgcaggtccgccttctcgGacagctgcgggtggcgggtg	4	8	17	12	4	1	0	0	0	1	0	3	1	2	1	2	5	3	2	2	5	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:49672194G>A	uc002efs.2	-	5	1167	c.869C>T	c.(868-870)TCC>TTC	p.S290F	ZNF423_uc010vgn.1_Missense_Mutation_p.S173F	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	290					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CGCCTTCTCGGACAGCTGCGG	0.602													5	73					0	0	0	0	A	49672194	A	A	49672194	3	1	65	1	0	0	0	0	1	0	0	0	17965	1174	41	2	3005	2	ZNF423	16	49672194	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2959230	49672194	40682559	452	13283											
PAPD5	64282	broad.mit.edu	37	chr16	50261849	50261849	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtatccttggagtcctctCaggcagttgggaaaatgcaa	11	11	11	8	0	1	0	1	0	1	0	4	2	3	2	2	3	1	4	2	3	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:50261849C>G	uc010vgo.1	+	12	1890	c.1855C>G	c.(1855-1857)CAG>GAG	p.Q619E	PAPD5_uc010cbi.2_RNA|PAPD5_uc002efz.2_Missense_Mutation_p.Q363E|PAPD5_uc002ega.2_Missense_Mutation_p.Q410E	NM_001040284	NP_001035374	Q8NDF8	PAPD5_HUMAN	PAP associated domain containing 5 isoform a	493	Ser-rich.				cell division|DNA replication|histone mRNA catabolic process|mitosis	cytoplasm|nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding				0		all_cancers(37;0.0452)		BRCA - Breast invasive adenocarcinoma(181;0.0843)|GBM - Glioblastoma multiforme(240;0.231)		GGAGTCCTCTCAGGCAGTTGG	0.488													6	72					0	0	0	0	G	50261849	G	G	50261849	3	3	65	1	0	0	0	0	1	0	0	0	11479	827	29	2	1901	2	PAPD5	16	50261849	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	589655	50261849	40092904	453	13284											
IRX5	10265	broad.mit.edu	37	chr16	54966679	54966680	+	Frame_Shift_Del	DEL	AG	-	-																															gcgcgccggcgcctcaagaaAgagaataaaatgacgtggac																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:54966679_54966680delAG	uc002ehv.2	+	2	519_520	c.519_520delAG	c.(517-522)AAAGAGfs	p.K173fs	IRX5_uc010cca.1_Frame_Shift_Del_p.K225fs|IRX5_uc002ehw.2_Frame_Shift_Del_p.K107fs	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	173_174	Homeobox; TALE-type.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						GCCTCAAGAAAGAGAATAAAAT	0.599													---	---	---								-	54966680	-	-	54966679	7	5	65	1	0	1	0	1	0	0	0	0	7886	69	3	0	525	0	IRX5	16	54966679	Frame_Shift_Del	DEL	AG	TCGA-CN-5369-01A-01D-1434-08	4704830	54966679	35388074	454	13285											
GPR114	221188	broad.mit.edu	37	chr16	57597804	57597804	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcacgccatgcagttcccCgccgagctgacccgggacgc	7	4	12	18	5	0	1	0	1	0	0	1	3	1	2	5	1	3	4	5	1	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:57597804C>A	uc002elx.3	+	5	427	c.342C>A	c.(340-342)CCC>CCA	p.P114P	GPR114_uc010vhr.1_Silent_p.P114P|GPR114_uc002ely.2_Silent_p.P114P	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	114	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						TGCAGTTCCCCGCCGAGCTGA	0.622													14	88					4.7546e-09	5.10409e-09	1	0	A	57597804	A	A	57597804	2	1	65	1	0	0	0	0	0	0	0	1	6669	639	23	3		3	GPR114	16	57597804	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2631125	57597804	32756949	455	13286											
CDH8	1006	broad.mit.edu	37	chr16	62055216	62055216	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacttgagactgattcatcGgagccatgtaaatgcaaggg	14	9	11	7	1	1	2	1	2	0	1	2	4	1	3	1	2	3	2	1	2	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:62055216G>T	uc002eog.1	-	2	344	c.92C>A	c.(91-93)CCG>CAG	p.P31Q		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	31					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CTGATTCATCGGAGCCATGTA	0.458													8	103					5.4927e-09	5.87635e-09	1	0	T	62055216	T	T	62055216	3	4	65	1	0	0	0	0	1	0	0	0	3131	1116	39	3	2351	3	CDH8	16	62055216	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	4457412	62055216	28299537	456	13287											
CMTM2	146225	broad.mit.edu	37	chr16	66613547	66613547	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caaagggggccaagccagagCcagcaccagctccacctcca	12	2	10	17	0	0	1	0	0	0	1	2	1	2	1	7	2	4	2	7	2	2	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:66613547C>T	uc002ept.2	+	1	197	c.37C>T	c.(37-39)CCA>TCA	p.P13S	CMTM2_uc010cdu.2_Missense_Mutation_p.P13S	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	chemokine-like factor superfamily 2	13					chemotaxis	extracellular space|integral to membrane	cytokine activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		CAAGCCAGAGCCAGCACCAGC	0.587													10	99					0	0	0	0	T	66613547	T	T	66613547	3	4	65	1	0	0	0	0	1	0	0	0	3598	739	26	4	39	4	CMTM2	16	66613547	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4558331	66613547	23741206	457	13288											
DDX19B	11269	broad.mit.edu	37	chr16	70367483	70367483	+	Nonstop_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattgagaaaatagccaacTgagaagctccaccagccact	16	6	8	11	0	0	3	0	2	0	3	1	5	1	3	4	0	4	1	4	0	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:70367483T>G	uc002eyo.2	+	12	1567	c.1438T>G	c.(1438-1440)TGA>GGA	p.*480G	DDX19B_uc010vly.1_Intron|DDX19A_uc002eys.2_Intron|DDX19B_uc010vlv.1_Nonstop_Mutation_p.*454G|DDX19B_uc010vlw.1_Nonstop_Mutation_p.*371G|DDX19B_uc002eyp.2_Nonstop_Mutation_p.*449G|DDX19B_uc002eyq.2_Nonstop_Mutation_p.*371G|DDX19B_uc002eyr.2_Nonstop_Mutation_p.*329G|DDX19B_uc010vlx.1_Nonstop_Mutation_p.*329G|uc002eyt.2_Intron	NM_007242	NP_009173	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform	480					mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			kidney(1)	1		Ovarian(137;0.0694)				AATAGCCAACTGAGAAGCTCC	0.537													9	92					0	0	0	0	G	70367483	G	G	70367483	4	3	65	1	0	0	0	0	0	0	0	0	4364	1593	55	5	1484	5	DDX19B	16	70367483	Nonstop_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	3753936	70367483	19987270	458	13289											
WDR59	79726	broad.mit.edu	37	chr16	74951881	74951881	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtctgatcccgggaccaCgtcaccagttgatagtcctt	9	10	10	12	2	2	2	1	2	1	0	4	3	4	3	4	2	0	1	4	2	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:74951881C>T	uc002fdh.1	-	11	1014	c.912G>A	c.(910-912)ACG>ACA	p.T304T	WDR59_uc002fdi.2_Silent_p.T304T|WDR59_uc002fdj.2_Silent_p.T304T|WDR59_uc002fdg.1_5'Flank	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	304	WD 6.									ovary(1)|breast(1)	2						CCCGGGACCACGTCACCAGTT	0.463													12	166					0	0	0	0	T	74951881	T	T	74951881	2	4	65	1	0	0	0	0	0	0	0	1	17376	523	19	1		1	WDR59	16	74951881	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4584398	74951881	15402872	459	13290											
BCAR1	9564	broad.mit.edu	37	chr16	75268875	75268875	+	Frame_Shift_Del	DEL	G	-	-																															agtcctgggaggtgaacttaGggggtgagggcaggggtcgt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:75268875delG	uc002fdv.2	-	5	2045	c.1922delC	c.(1921-1923)CCTfs	p.P641fs	BCAR1_uc002fdt.2_Frame_Shift_Del_p.P94fs|BCAR1_uc002fdu.2_Frame_Shift_Del_p.P431fs|BCAR1_uc010cgu.2_Frame_Shift_Del_p.P630fs|BCAR1_uc010vna.1_Frame_Shift_Del_p.P639fs|BCAR1_uc010vnb.1_Frame_Shift_Del_p.P687fs|BCAR1_uc002fdw.2_Frame_Shift_Del_p.P641fs|BCAR1_uc010vnc.1_Frame_Shift_Del_p.P493fs|BCAR1_uc010vnd.1_Frame_Shift_Del_p.P659fs|BCAR1_uc002fdx.2_Frame_Shift_Del_p.P659fs	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	641	SH3-binding (Potential).				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGTGAACTTAGGGGGTGAGGG	0.657													---	---	---								-	75268875	-	-	75268875	7	5	65	1	0	1	0	1	0	0	0	0	1350	1000	35	0	702	0	BCAR1	16	75268875	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	316994	75268875	15085878	460	13291											
CHST6	4166	broad.mit.edu	37	chr16	75513534	75513534	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctccattaggtagaagacgtCggggtgctggttgaagagtt	9	11	15	6	2	0	4	0	1	0	3	2	4	1	4	1	4	1	4	1	4	4	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:75513534C>G	uc002fef.2	-	3	373	c.193G>C	c.(193-195)GAC>CAC	p.D65H	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.D65H	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	65	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						TAGAAGACGTCGGGGTGCTGG	0.687													5	40					0	0	0	0	G	75513534	G	G	75513534	3	3	65	1	0	0	0	0	1	0	0	0	3423	884	31	3	998	3	CHST6	16	75513534	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	244659	75513534	14841219	461	13292											
PKD1L2	114780	broad.mit.edu	37	chr16	81253937	81253937	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtggtggccctaagcctCagagcaagcaccaggagtac	12	5	12	12	0	1	1	1	0	0	1	1	2	1	2	3	3	4	3	3	3	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:81253937C>A	uc002fgh.1	-	1	39	c.39G>T	c.(37-39)CTG>CTT	p.L13L	PKD1L2_uc002fgj.2_Silent_p.L13L	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	13					neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCCTAAGCCTCAGAGCAAGCA	0.557													9	79					0.000442599	0.000451955	1	0	A	81253937	A	A	81253937	2	1	65	1	0	0	0	0	0	0	0	1	12020	813	29	2		2	PKD1L2	16	81253937	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	5740403	81253937	9100816	462	13293											
OSGIN1	29948	broad.mit.edu	37	chr16	83999318	83999318	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggccgtgttccaggacctCgagggtgtcgagaaggtgtt	7	9	16	9	3	0	1	0	0	0	1	3	4	1	2	3	4	0	2	3	4	1	2	rs149907599	byFrequency	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:83999318C>T	uc002fha.2	+	7	1772	c.1389C>T	c.(1387-1389)CTC>CTT	p.L463L	NECAB2_uc002fhd.2_5'Flank|OSGIN1_uc002fhb.2_Silent_p.L380L|OSGIN1_uc002fhc.2_Silent_p.L380L	NM_013370	NP_037502	Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	463					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity				0						TCCAGGACCTCGAGGGTGTCG	0.642													7	104					0	0	0	0	T	83999318	T	T	83999318	2	4	65	1	0	0	0	0	0	0	0	1	11343	871	31	1		1	OSGIN1	16	83999318	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2745381	83999318	6355435	463	13294											
CTU2	348180	broad.mit.edu	37	chr16	88778042	88778042	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctgctgcttctccctctaGggcctgagccaagattctgc	5	11	9	16	0	3	2	0	1	3	1	4	2	3	2	4	1	4	2	4	1	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:88778042G>T	uc002flm.2	+	5	331	c.283_splice	c.e5-1	p.G95_splice	CTU2_uc002fln.2_Splice_Site_p.G95_splice|CTU2_uc010chz.2_Splice_Site_p.G95_splice|CTU2_uc010cia.2_Splice_Site_p.G8_splice	NM_001012759	NP_001012777	Q2VPK5	CTU2_HUMAN	cytoplasmic tRNA 2-thiolation protein 2 isoform						tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			skin(1)	1						TCTCCCTCTAGGGCCTGAGCC	0.527													9	97					4.68919e-08	4.94926e-08	1	0	T	88778042	T	T	88778042	5	4	65	1	0	0	0	0	0	0	1	0	4065	1014	35	4	300	4	CTU2	16	88778042	Splice_Site	SNP	G	TCGA-CN-5369-01A-01D-1434-08	4778724	88778042	1576711	464	13295											
CDH15	1013	broad.mit.edu	37	chr16	89254679	89254679	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaagaccaacgagggtgttCtgtccattgtgaaggtgagc	10	9	13	9	1	1	3	0	2	1	1	2	4	2	3	3	2	2	1	3	2	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr16:89254679C>T	uc002fmt.2	+	7	1041	c.964C>T	c.(964-966)CTG>TTG	p.L322L		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	322	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CGAGGGTGTTCTGTCCATTGT	0.637													5	43					0	0	0	0	T	89254679	T	T	89254679	2	4	65	1	0	0	0	0	0	0	0	1	3115	912	32	2		2	CDH15	16	89254679	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	476637	89254679	1100074	465	13296											
RAP1GAP2	23108	broad.mit.edu	37	chr17	2867170	2867170	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttgtggagaagggaggcccGtaccctcaggtcatcctgcc	7	8	14	12	1	2	1	2	0	0	1	3	3	3	2	4	4	2	2	4	4	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:2867170G>A	uc010ckd.2	+	7	390	c.300G>A	c.(298-300)CCG>CCA	p.P100P	RAP1GAP2_uc010cke.2_Silent_p.P85P	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	100					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						AGGGAGGCCCGTACCCTCAGG	0.672													3	21					0	0	0	0	A	2867170	A	A	2867170	2	1	65	1	0	0	0	0	0	0	0	1	13103	1132	40	1		1	RAP1GAP2	17	2867170	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08		2867170	78328040	466	13297											
ACADVL	37	broad.mit.edu	37	chr17	7127027	7127027	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggacttccagatagaggccgCcatcagcaaaatctttggct	11	9	10	11	1	2	2	1	0	1	2	3	3	3	3	3	3	1	2	3	3	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:7127027C>T	uc002gev.2	+	12	1398	c.1247C>T	c.(1246-1248)GCC>GTC	p.A416V	ACADVL_uc010vtp.1_Missense_Mutation_p.A426V|ACADVL_uc002gew.2_Missense_Mutation_p.A394V|ACADVL_uc002gex.2_Missense_Mutation_p.A340V|uc002gey.1_5'Flank|MIR324_hsa-mir-324|MI0000813_5'Flank	NM_000018	NP_000009	P49748	ACADV_HUMAN	acyl-Coenzyme A dehydrogenase, very long chain	416	Catalytic.				energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			ovary(3)	3						ATAGAGGCCGCCATCAGCAAA	0.532													15	145					0	0	0	0	T	7127027	T	T	7127027	3	4	65	1	0	0	0	0	1	0	0	0	116	739	26	4	1293	4	ACADVL	17	7127027	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4259857	7127027	74068183	467	13298											
NEURL4	84461	broad.mit.edu	37	chr17	7227188	7227188	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgacagttgtggcggagggCggtgcggcccccgttagtga	5	7	19	10	5	0	1	0	1	0	0	0	3	0	2	2	5	1	2	2	5	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:7227188C>T	uc002gga.1	-	12	2213	c.2206G>A	c.(2206-2208)GCC>ACC	p.A736T	NEURL4_uc002ggb.1_Missense_Mutation_p.A736T|NEURL4_uc002ggc.1_Missense_Mutation_p.A82T	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	736	NHR 4.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGGCGGAGGGCGGTGCGGCCC	0.622											OREG0024134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	105					0	0	0	0	T	7227188	T	T	7227188	3	4	65	1	0	0	0	0	1	0	0	0	10401	768	27	1	2554	1	NEURL4	17	7227188	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	100161	7227188	73968022	468	13299											
DNAH2	146754	broad.mit.edu	37	chr17	7701100	7701100	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagtataacctgtcaccctCtgtcgtgcccatgcagctag	8	11	9	13	1	2	1	1	1	1	0	3	1	2	1	3	0	4	3	3	0	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:7701100C>G	uc002giu.1	+	52	8197	c.8183C>G	c.(8182-8184)TCT>TGT	p.S2728C		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2728	AAA 4 (By similarity).|TPR 2.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTGTCACCCTCTGTCGTGCCC	0.522													18	220					0	0	0	0	G	7701100	G	G	7701100	3	3	65	1	0	0	0	0	1	0	0	0	4624	913	32	2	8389	2	DNAH2	17	7701100	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	473912	7701100	73494110	469	13300											
MYH2	4620	broad.mit.edu	37	chr17	10430045	10430045	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggattcctgctcctcctcaTactgttcccgcagcaggtca	6	12	8	15	1	2	0	2	0	0	0	6	1	6	1	4	2	3	4	4	2	1	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:10430045T>C	uc010coi.2	-	30	4186	c.4058A>G	c.(4057-4059)TAT>TGT	p.Y1353C	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.Y1353C|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1353	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTCCTCCTCATACTGTTCCCG	0.582													15	175					0	0	0	0	C	10430045	C	C	10430045	3	2	65	1	0	0	0	0	1	0	0	0	10088	1406	49	5	1811	5	MYH2	17	10430045	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	2728945	10430045	70765165	470	13301											
MYH3	4621	broad.mit.edu	37	chr17	10541713	10541713	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttcgcgcgggtggccctctCcgcctctatctcctcttcca	2	12	8	19	4	4	0	0	0	4	0	8	0	5	0	5	2	0	0	5	2	1	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:10541713C>T	uc002gmq.1	-	26	3453	c.3376G>A	c.(3376-3378)GAG>AAG	p.E1126K		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1126	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						GTGGCCCTCTCCGCCTCTATC	0.657													5	66					0	0	0	0	T	10541713	T	T	10541713	3	4	65	1	0	0	0	0	1	0	0	0	10089	864	30	2	2506	2	MYH3	17	10541713	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	111668	10541713	70653497	471	13302											
RICH2	9912	broad.mit.edu	37	chr17	12847469	12847469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggagatcgccttccccatcGaggcgtgtgtgaccatgctg	6	9	14	12	3	0	2	0	1	0	1	3	4	1	2	4	2	1	1	4	2	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:12847469G>A	uc002gnr.3	+	10	1144	c.817G>A	c.(817-819)GAG>AAG	p.E273K	RICH2_uc010vvk.1_Missense_Mutation_p.E273K|RICH2_uc010vvl.1_Missense_Mutation_p.E273K|RICH2_uc002gns.3_Missense_Mutation_p.E73K|RICH2_uc010vvm.1_Missense_Mutation_p.E273K|RICH2_uc010vvn.1_RNA|RICH2_uc002gnt.1_5'UTR	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	273	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						CTTCCCCATCGAGGCGTGTGT	0.642													11	64					0	0	0	0	A	12847469	A	A	12847469	3	1	65	1	0	0	0	0	1	0	0	0	13422	1059	37	1	855	1	RICH2	17	12847469	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2305756	12847469	68347741	472	13303											
SMCR7	125170	broad.mit.edu	37	chr17	18167389	18167389	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accctcgctgctgggccgtgCgcaggacgcagcttgagttc	5	8	14	14	4	0	1	0	1	0	0	2	2	0	2	2	2	3	6	2	2	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:18167389C>T	uc002gst.2	+	4	887	c.676C>T	c.(676-678)CGC>TGC	p.R226C	SMCR7_uc002gsu.2_Missense_Mutation_p.A201V|SMCR7_uc010vxq.1_Missense_Mutation_p.R237C	NM_139162	NP_631901	Q96C03	SMCR7_HUMAN	Smith-Magenis syndrome chromosome region,	226						integral to membrane	protein binding				0	all_neural(463;0.228)					CTGGGCCGTGCGCAGGACGCA	0.711													3	7					0	0	0	0	T	18167389	T	T	18167389	3	4	65	1	0	0	0	0	1	0	0	0	14854	768	27	1	723	1	SMCR7	17	18167389	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	5319920	18167389	63027821	473	13304											
SLC13A2	9058	broad.mit.edu	37	chr17	26820669	26820669	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtcatccagaccgagcacaGgctgctgggccccatgacct	8	6	11	16	2	1	2	1	1	0	1	2	3	2	2	5	2	2	3	5	2	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:26820669G>T	uc002hbh.2	+	7	1026	c.959G>T	c.(958-960)AGG>ATG	p.R320M	SLC13A2_uc010wal.1_Missense_Mutation_p.R277M|SLC13A2_uc010wam.1_Missense_Mutation_p.R276M|SLC13A2_uc010wan.1_Missense_Mutation_p.R369M|SLC13A2_uc010wao.1_Missense_Mutation_p.R277M|SLC13A2_uc002hbi.2_Missense_Mutation_p.R249M	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	320						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	ACCGAGCACAGGCTGCTGGGC	0.587													5	78					3.59834e-05	3.69845e-05	1	0	T	26820669	T	T	26820669	3	4	65	1	0	0	0	0	1	0	0	0	14457	1000	35	4	1132	4	SLC13A2	17	26820669	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	8653280	26820669	54374541	474	13305											
SSH2	85464	broad.mit.edu	37	chr17	27963208	27963208	+	Frame_Shift_Del	DEL	A	-	-																															acaaacttctctagggcactAaaaaagtcaatgcgatctgt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:27963208delA	uc002heo.1	-	14	1959	c.1959delT	c.(1957-1959)TTTfs	p.F653fs	SSH2_uc010wbh.1_Frame_Shift_Del_p.F680fs	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	653					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						CTAGGGCACTAAAAAAGTCAA	0.502													---	---	---								-	27963208	-	-	27963208	7	5	65	1	0	1	0	1	0	0	0	0	15251	359	13	0	2320	0	SSH2	17	27963208	Frame_Shift_Del	DEL	A	TCGA-CN-5369-01A-01D-1434-08	1142539	27963208	53232002	475	13306											
ATAD5	79915	broad.mit.edu	37	chr17	29206468	29206468	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atttagtttaatgtttgatgGctgctttgaagaaatcaagt	12	17	9	3	0	1	3	1	2	0	1	1	3	1	3	0	1	1	4	0	1	5	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:29206468G>A	uc002hfs.1	+	18	4386	c.4040G>A	c.(4039-4041)GGC>GAC	p.G1347D		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1347					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ATGTTTGATGGCTGCTTTGAA	0.294													16	115					0	0	0	0	A	29206468	A	A	29206468	3	1	65	1	0	0	0	0	1	0	0	0	1078	1203	42	4	4110	4	ATAD5	17	29206468	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1243260	29206468	51988742	476	13307											
MRM1	79922	broad.mit.edu	37	chr17	34964340	34964340	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccacgccctgcagggaatGagggctcaggtctatcccag	8	6	12	15	1	2	1	1	1	1	0	3	2	3	2	4	3	1	2	4	3	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:34964340G>A	uc002hne.2	+	4	990	c.775G>A	c.(775-777)GAG>AAG	p.E259K	MRM1_uc002hnf.2_Missense_Mutation_p.E64K	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	259					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		TGCAGGGAATGAGGGCTCAGG	0.617													8	88					0	0	0	0	A	34964340	A	A	34964340	3	1	65	1	0	0	0	0	1	0	0	0	9824	1291	45	2	789	2	MRM1	17	34964340	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	5757872	34964340	46230870	477	13308											
IKZF3	22806	broad.mit.edu	37	chr17	37922297	37922297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcgggggcttgaggagttCgtaagagcggggaacctcct	7	7	19	8	3	0	2	0	1	0	1	2	4	1	4	2	6	2	3	2	6	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:37922297C>T	uc002hsu.2	-	8	1338	c.1276G>A	c.(1276-1278)GAA>AAA	p.E426K	IKZF3_uc002htd.2_Missense_Mutation_p.E392K|IKZF3_uc010cwd.2_Missense_Mutation_p.E283K|IKZF3_uc002hsv.2_Missense_Mutation_p.E353K|IKZF3_uc010cwe.2_Missense_Mutation_p.E292K|IKZF3_uc010cwf.2_Missense_Mutation_p.E244K|IKZF3_uc010cwg.2_Missense_Mutation_p.E205K|IKZF3_uc002hsw.2_Missense_Mutation_p.E387K|IKZF3_uc002hsx.2_Missense_Mutation_p.E370K|IKZF3_uc002hsy.2_Missense_Mutation_p.E387K|IKZF3_uc002hsz.2_Missense_Mutation_p.E331K|IKZF3_uc002hta.2_Missense_Mutation_p.E348K|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Missense_Mutation_p.E339K|IKZF3_uc002htc.2_Missense_Mutation_p.E179K|IKZF3_uc010wel.1_Missense_Mutation_p.E179K	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	426					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TTGAGGAGTTCGTAAGAGCGG	0.552													23	244					0	0	0	0	T	37922297	T	T	37922297	3	4	65	1	0	0	0	0	1	0	0	0	7655	893	31	1	257	1	IKZF3	17	37922297	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2957957	37922297	43272913	478	13309											
MLX	6945	broad.mit.edu	37	chr17	40722105	40722105	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttcaaggcatcatggattcCctgttccagtccttcaatgc	8	14	7	12	0	3	0	3	0	0	0	6	1	6	1	3	2	1	2	3	2	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:40722105C>A	uc002iag.2	+	7	809	c.744C>A	c.(742-744)TCC>TCA	p.S248S	MLX_uc002iaf.2_Silent_p.S194S|MLX_uc002iah.2_Silent_p.S164S	NM_170607	NP_733752	Q9UH92	MLX_HUMAN	transcription factor-like protein 4 isoform	248					energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TCATGGATTCCCTGTTCCAGT	0.537													10	143					2.52707e-12	2.76963e-12	1	0	A	40722105	A	A	40722105	2	1	65	1	0	0	0	0	0	0	0	1	9688	610	22	4		4	MLX	17	40722105	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2799808	40722105	40473105	479	13310											
WNK4	65266	broad.mit.edu	37	chr17	40939870	40939870	+	Frame_Shift_Del	DEL	G	-	-																															accctgcccttcagccccctGggggggtgccatccagcctg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:40939870delG	uc002ibj.2	+	8	1837	c.1816delG	c.(1816-1818)GGGfs	p.G606fs	WNK4_uc010wgx.1_Frame_Shift_Del_p.G270fs|WNK4_uc002ibk.1_Frame_Shift_Del_p.G378fs|WNK4_uc010wgy.1_Intron	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	606					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TCAGCCCCCTGGGGGGGTGCC	0.637													---	---	---								-	40939870	-	-	40939870	7	5	65	1	0	1	0	1	0	0	0	0	17448	1348	47	0	1846	0	WNK4	17	40939870	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	217765	40939870	40255340	480	13311											
RPRML	388394	broad.mit.edu	37	chr17	45056080	45056080	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctgcaccagaaagttgatCatgctctcggacttgatgag	10	11	10	10	1	2	4	1	3	1	1	4	5	3	5	2	1	2	3	2	1	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:45056080C>G	uc002ilb.2	-	1	535	c.294G>C	c.(292-294)ATG>ATC	p.M98I	GOSR2_uc010wkh.1_Intron	NM_203400	NP_981945	Q8N4K4	RPRML_HUMAN	reprimo-like	98						integral to membrane					0						GAAAGTTGATCATGCTCTCGG	0.657													5	32					0	0	0	0	G	45056080	G	G	45056080	3	3	65	1	0	0	0	0	1	0	0	0	13684	826	29	2	72	2	RPRML	17	45056080	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4116210	45056080	36139130	481	13312											
OSBPL7	114881	broad.mit.edu	37	chr17	45888197	45888197	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgagataggggggtggtggGagaccttggtgagcaaagaa	11	6	19	5	1	0	4	0	1	0	3	0	6	0	4	2	6	1	1	2	6	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:45888197G>A	uc002ilx.1	-	17	1945	c.1742C>T	c.(1741-1743)TCC>TTC	p.S581F	OSBPL7_uc002ilw.1_Missense_Mutation_p.S143F	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	581					lipid transport		lipid binding				0						GGGGTGGTGGGAGACCTTGGT	0.587													4	36					0	0	0	0	A	45888197	A	A	45888197	3	1	65	1	0	0	0	0	1	0	0	0	11336	1174	41	2	814	2	OSBPL7	17	45888197	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	832117	45888197	35307013	482	13313											
SP6	80320	broad.mit.edu	37	chr17	45924834	45924834	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcgctgcgcatgaagacgCggctgcagactgcacagggg	8	5	17	11	4	0	3	0	1	0	2	1	3	0	3	0	4	3	5	0	4	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:45924834C>T	uc002img.1	-	2	1294	c.962G>A	c.(961-963)CGC>CAC	p.R321H	SP6_uc002imh.1_Missense_Mutation_p.R321H	NM_199262	NP_954871	Q3SY56	SP6_HUMAN	Sp6 transcription factor	321	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CATGAAGACGCGGCTGCAGAC	0.682													5	70					0	0	0	0	T	45924834	T	T	45924834	3	4	65	1	0	0	0	0	1	0	0	0	15032	768	27	1	172	1	SP6	17	45924834	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	36637	45924834	35270376	483	13314											
FAM117A	81558	broad.mit.edu	37	chr17	47797166	47797166	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctccttcacaaatacctcctCcagctcttggttgagccctt	7	13	5	16	0	2	1	1	1	1	0	5	1	5	1	5	1	3	2	5	1	2	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:47797166C>G	uc002ipk.2	-	5	733	c.664G>C	c.(664-666)GAG>CAG	p.E222Q	FAM117A_uc010wlz.1_5'UTR	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	222										ovary(1)	1						AATACCTCCTCCAGCTCTTGG	0.637													13	188					0	0	0	0	G	47797166	G	G	47797166	3	3	65	1	0	0	0	0	1	0	0	0	5437	864	30	2	713	2	FAM117A	17	47797166	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1872332	47797166	33398044	484	13315											
XYLT2	64132	broad.mit.edu	37	chr17	48433967	48433967	+	Frame_Shift_Del	DEL	C	-	-																															ttccacctgtatggcagctaCccccccggcacgccagccct																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:48433967delC	uc002iqo.2	+	8	1687	c.1578delC	c.(1576-1578)TACfs	p.Y526fs	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	526	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					ATGGCAGCTACCCCCCCGGCA	0.602													---	---	---								-	48433967	-	-	48433967	7	5	65	1	0	1	0	1	0	0	0	0	17532	518	18	0	1608	0	XYLT2	17	48433967	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	636801	48433967	32761243	485	13316											
USP32	84669	broad.mit.edu	37	chr17	58303585	58303585	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atggctcaattaccacagggTtggcatcctaaaatcaggaa	14	9	9	9	0	2	0	2	0	0	0	3	1	3	1	2	4	1	3	2	4	5	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:58303585T>C	uc002iyo.1	-	13	1533	c.1247A>G	c.(1246-1248)AAC>AGC	p.N416S	USP32_uc002iyn.1_Missense_Mutation_p.N86S	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	416	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TACCACAGGGTTGGCATCCTA	0.368													8	83					0	0	0	0	C	58303585	C	C	58303585	3	2	65	1	0	0	0	0	1	0	0	0	17131	1725	60	5	3655	5	USP32	17	58303585	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	9869618	58303585	22891625	486	13317											
SMURF2	64750	broad.mit.edu	37	chr17	62543753	62543753	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccctgcagaggcactcgaGaggatcctgtcacaaactga	12	6	11	12	1	1	3	1	1	0	2	3	5	2	4	2	2	3	2	2	2	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:62543753G>A	uc002jep.1	-	17	2424	c.2036C>T	c.(2035-2037)TCT>TTT	p.S679F	SMURF2_uc002jeq.1_Missense_Mutation_p.S438F|SMURF2_uc002jer.1_Missense_Mutation_p.S438F	NM_022739	NP_073576	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	679	HECT.				BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			AGGCACTCGAGAGGATCCTGT	0.547													7	128					0	0	0	0	A	62543753	A	A	62543753	3	1	65	1	0	0	0	0	1	0	0	0	14884	942	33	2	222	2	SMURF2	17	62543753	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	4240168	62543753	18651457	487	13318											
ABCA6	23460	broad.mit.edu	37	chr17	67079125	67079125	+	Frame_Shift_Del	DEL	T	-	-																															tgtaatccttgccaagtttgTttttcaggtgttggatggag																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:67079125delT	uc002jhw.1	-	36	4680	c.4505delA	c.(4504-4506)AACfs	p.N1502fs		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1502	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					GCCAAGTTTGTTTTTCAGGTG	0.373													---	---	---								-	67079125	-	-	67079125	7	5	65	1	0	1	0	1	0	0	0	0	36	1725	60	0	364	0	ABCA6	17	67079125	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	4535372	67079125	14116085	488	13319											
SDK2	54549	broad.mit.edu	37	chr17	71334758	71334758	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgaaaatcctgctatgggagCccgggagcctggggccaggc	8	6	16	11	1	0	1	0	1	0	0	1	3	1	3	4	5	3	1	4	5	3	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:71334758C>T	uc010dfm.2	-	45	6487	c.6487G>A	c.(6487-6489)GCT>ACT	p.A2163T	SDK2_uc002jjt.3_Missense_Mutation_p.A1303T	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	2163	Cytoplasmic (Potential).				cell adhesion	integral to membrane				ovary(2)	2						GCTATGGGAGCCCGGGAGCCT	0.582													8	42					0	0	0	0	T	71334758	T	T	71334758	3	4	65	1	0	0	0	0	1	0	0	0	14034	739	26	4	35	4	SDK2	17	71334758	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4255633	71334758	9860452	489	13320											
ITGB4	3691	broad.mit.edu	37	chr17	73738804	73738804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgcaggcactgccaccctcgGccgccgcctggtaaacatca	8	5	10	18	4	1	0	1	0	0	0	2	0	1	0	5	3	2	3	5	3	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:73738804G>A	uc002jpg.2	+	25	3111	c.2924G>A	c.(2923-2925)GGC>GAC	p.G975D	ITGB4_uc002jph.2_Missense_Mutation_p.G975D|ITGB4_uc002jpi.3_Missense_Mutation_p.G975D|ITGB4_uc010dgp.1_3'UTR|ITGB4_uc002jpj.2_Missense_Mutation_p.G975D	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	975	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCACCCTCGGCCGCCGCCTG	0.498													5	52					0	0	0	0	A	73738804	A	A	73738804	3	1	65	1	0	0	0	0	1	0	0	0	7936	1203	42	4	3018	4	ITGB4	17	73738804	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2404046	73738804	7456406	490	13321											
TNRC6C	57690	broad.mit.edu	37	chr17	76046980	76046980	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggacacttgggggatgggAaaaaaaatggatctggatgg	13	9	16	3	0	1	0	0	0	1	0	1	5	1	5	0	7	0	0	0	7	4	2	rs71717398		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:76046980A>G	uc002jud.2	+	4	2437	c.1837A>G	c.(1837-1839)AAA>GAA	p.K613E	TNRC6C_uc002juf.2_Missense_Mutation_p.K613E|TNRC6C_uc002jue.2_Missense_Mutation_p.K613E	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	613	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GGGGGATGGGAAAAAAAATGG	0.522													11	116					0	0	0	0	G	76046980	G	G	76046980	3	3	65	1	0	0	0	0	1	0	0	0	16408	247	9	5	1839	5	TNRC6C	17	76046980	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	2308176	76046980	5148230	491	13322											
GAA	2548	broad.mit.edu	37	chr17	78081373	78081373	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggctgaacacgacggtggCgcccctgttctttgcggacc	6	8	13	14	4	1	1	0	1	1	0	1	3	1	2	3	4	2	2	3	4	1	2	rs121907944		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:78081373C>T	uc002jxo.2	+	5	892	c.710C>T	c.(709-711)GCG>GTG	p.A237V	GAA_uc002jxp.2_Missense_Mutation_p.A237V|GAA_uc002jxq.2_Missense_Mutation_p.A237V	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	237			A -> V (in GSD2).		cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	ACGACGGTGGCGCCCCTGTTC	0.662													24	226					0	0	0	0	T	78081373	T	T	78081373	3	4	65	1	0	0	0	0	1	0	0	0	6181	768	27	1	720	1	GAA	17	78081373	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2034393	78081373	3113837	492	13323											
ZNF750	79755	broad.mit.edu	37	chr17	80790043	80790044	+	Frame_Shift_Del	DEL	AG	-	-																															tgaagcttcgagtcgaaggcAgagagtccatttgcgacaga																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr17:80790043_80790044delAG	uc002kga.2	-	2	598_599	c.287_288delCT	c.(286-288)TCTfs	p.S96fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	96						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGTCGAAGGCAGAGAGTCCATT	0.574													---	---	---								-	80790044	-	-	80790043	7	5	65	1	0	1	0	1	0	0	0	0	18199	175	7	0	1891	0	ZNF750	17	80790043	Frame_Shift_Del	DEL	AG	TCGA-CN-5369-01A-01D-1434-08	2708670	80790043	405167	493	13324											
LAMA1	284217	broad.mit.edu	37	chr18	6983142	6983142	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgagcatctctggccagttCctccgattcttcaatcaggc	7	12	9	13	1	4	1	2	1	2	0	7	2	6	1	3	2	1	2	3	2	1	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:6983142C>A	uc002knm.2	-	40	5846	c.5752G>T	c.(5752-5754)GAA>TAA	p.E1918*	LAMA1_uc010wzj.1_Nonsense_Mutation_p.E1394*	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1918	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGGCCAGTTCCTCCGATTCT	0.498													15	106					6.31663e-08	6.65577e-08	1	0	A	6983142	A	A	6983142	4	1	65	1	0	0	0	0	0	1	0	0	8645	864	30	2	3571	2	LAMA1	18	6983142	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08		6983142	71094106	494	13325											
CEP192	55125	broad.mit.edu	37	chr18	13095576	13095576	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtcaaaggtcctcagggttCtcctcttctctcacgggcgg	6	11	11	13	2	6	0	3	0	3	0	9	0	7	0	2	4	0	1	2	4	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:13095576C>T	uc010xac.1	+	35	6409	c.6329C>T	c.(6328-6330)TCT>TTT	p.S2110F	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.S1635F|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.S532F|CEP192_uc002krw.2_Missense_Mutation_p.S259F|CEP192_uc002krx.2_Missense_Mutation_p.S114F|CEP192_uc002kry.2_RNA	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	2110										ovary(4)|pancreas(1)	5						CCTCAGGGTTCTCCTCTTCTC	0.507													18	186					0	0	0	0	T	13095576	T	T	13095576	3	4	65	1	0	0	0	0	1	0	0	0	3266	913	32	2	6463	2	CEP192	18	13095576	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6112434	13095576	64981672	495	13326											
MIB1	57534	broad.mit.edu	37	chr18	19418387	19418387	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtggatgagaagaaagatGatggttatactgccttacat	13	13	11	4	0	0	4	0	2	0	3	0	6	0	5	1	2	3	1	1	2	5	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:19418387G>T	uc002ktq.2	+	13	1891	c.1891G>T	c.(1891-1893)GAT>TAT	p.D631Y	MIB1_uc002ktp.2_Missense_Mutation_p.D270Y	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	631	ANK 7.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			GAAGAAAGATGATGGTTATAC	0.348													9	99					1.12685e-05	1.16776e-05	1	0	T	19418387	T	T	19418387	3	4	65	1	0	0	0	0	1	0	0	0	9619	1290	45	2	1941	2	MIB1	18	19418387	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6322811	19418387	58658861	496	13327											
NOL4	8715	broad.mit.edu	37	chr18	31538274	31538274	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccgaatcgtcatggtcctCgtggtcatcttcgtcctcat	5	14	8	14	4	4	0	3	0	1	0	10	1	7	0	3	2	0	0	3	2	1	1	rs137958344		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:31538274C>T	uc010dmi.2	-	7	1394	c.1165G>A	c.(1165-1167)GAG>AAG	p.E389K	NOL4_uc010xbs.1_Missense_Mutation_p.E104K|NOL4_uc002kxr.3_Missense_Mutation_p.E225K|NOL4_uc010xbt.1_Missense_Mutation_p.E315K|NOL4_uc010dmh.2_Missense_Mutation_p.E315K|NOL4_uc010xbu.1_Missense_Mutation_p.E389K|NOL4_uc002kxt.3_Missense_Mutation_p.E389K|NOL4_uc010xbv.1_Missense_Mutation_p.E138K|NOL4_uc010xbw.1_Missense_Mutation_p.E275K	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	389						nucleolus	RNA binding			ovary(3)	3						TCATGGTCCTCGTGGTCATCT	0.498													29	329					0	0	0	0	T	31538274	T	T	31538274	3	4	65	1	0	0	0	0	1	0	0	0	10578	893	31	1	771	1	NOL4	18	31538274	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	12119887	31538274	46538974	497	13328											
GALNT1	2589	broad.mit.edu	37	chr18	33269223	33269223	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgatgctggaatggatatttGgggaggagaaaacctagaaa	15	9	14	3	0	0	3	0	1	0	2	0	7	0	6	1	5	2	1	1	5	6	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:33269223G>A	uc010dmu.2	+	7	1000	c.947G>A	c.(946-948)TGG>TAG	p.W316*	GALNT1_uc002kyz.3_Nonsense_Mutation_p.W256*|GALNT1_uc002kzb.2_Nonsense_Mutation_p.W316*	NM_020474	NP_065207	Q10472	GALT1_HUMAN	polypeptide N-acetylgalactosaminyltransferase 1	316	Lumenal (Potential).|Catalytic subdomain B.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						ATGGATATTTGGGGAGGAGAA	0.333													16	143					0	0	0	0	A	33269223	A	A	33269223	4	1	65	1	0	0	0	0	0	1	0	0	6242	1357	47	4	969	4	GALNT1	18	33269223	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1730949	33269223	44808025	498	13329											
PSTPIP2	9050	broad.mit.edu	37	chr18	43573663	43573663	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgttcacattcttgagcctCaaatgcctacagaaaaatag	14	11	6	10	1	3	2	2	1	1	1	4	2	3	2	2	0	3	1	2	0	5	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:43573663C>G	uc002lbp.3	-	10	745	c.649G>C	c.(649-651)GAG>CAG	p.E217Q	PSTPIP2_uc002lbq.3_Missense_Mutation_p.E217Q	NM_024430	NP_077748	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting	217						membrane				ovary(1)	1						TCTTGAGCCTCAAATGCCTAC	0.398													9	54					0	0	0	0	G	43573663	G	G	43573663	3	3	65	1	0	0	0	0	1	0	0	0	12784	835	29	2	375	2	PSTPIP2	18	43573663	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	10304440	43573663	34503585	499	13330											
WDR7	23335	broad.mit.edu	37	chr18	54448880	54448880	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcagtacatagaccacgtCatatcacgtaagagttctca	13	10	6	12	2	4	2	4	0	1	2	5	2	4	2	2	0	1	3	2	0	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:54448880C>A	uc002lgk.1	+	19	3394	c.3183C>A	c.(3181-3183)GTC>GTA	p.V1061V	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Silent_p.V1028V	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1061										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TAGACCACGTCATATCACGTA	0.453													8	124					0.00307968	0.00311439	1	0	A	54448880	A	A	54448880	2	1	65	1	0	0	0	0	0	0	0	1	17388	813	29	2		2	WDR7	18	54448880	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	10875217	54448880	23628368	500	13331											
NARS	4677	broad.mit.edu	37	chr18	55274847	55274847	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagctcctccagcaggggcCaacccaattagttcccagaa	11	7	8	15	0	1	1	1	0	0	1	4	1	4	1	5	2	3	3	5	2	4	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:55274847C>T	uc002lgs.2	-	8	858	c.630G>A	c.(628-630)TTG>TTA	p.L210L	NARS_uc002lgt.2_Silent_p.L209L|NARS_uc010xea.1_Intron|NARS_uc010xeb.1_RNA|NARS_uc010xec.1_Silent_p.L210L|NARS_uc010xed.1_Silent_p.L177L	NM_004539	NP_004530	O43776	SYNC_HUMAN	asparaginyl-tRNA synthetase	210					asparaginyl-tRNA aminoacylation	cytosol|soluble fraction	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding				0		Colorectal(73;0.227)			L-Asparagine(DB00174)	CAGCAGGGGCCAACCCAATTA	0.478													8	64					0	0	0	0	T	55274847	T	T	55274847	2	4	65	1	0	0	0	0	0	0	0	1	10223	593	21	4		4	NARS	18	55274847	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	825967	55274847	22802401	501	13332											
SOCS6	9306	broad.mit.edu	37	chr18	67993105	67993105	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagggaagctagcaaacGtgccagatggttcttttctt	11	11	11	8	1	2	2	0	0	2	2	2	3	2	3	1	2	4	3	1	2	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:67993105G>A	uc002lkr.1	+	2	1517	c.1201G>A	c.(1201-1203)GTG>ATG	p.V401M	SOCS6_uc010dqq.2_Missense_Mutation_p.V401M	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	401	SH2.				defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				GCTAGCAAACGTGCCAGATGG	0.473													15	137					0	0	0	0	A	67993105	A	A	67993105	3	1	65	1	0	0	0	0	1	0	0	0	14982	1145	40	1	1203	1	SOCS6	18	67993105	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	12718258	67993105	10084143	502	13333											
NFATC1	4772	broad.mit.edu	37	chr18	77170881	77170881	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtacgcgtccccccagacGtcgccatggcagtctccctg	5	7	10	19	5	1	1	0	0	1	1	4	1	2	1	6	1	1	2	6	1	1	1	rs146509068		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:77170881G>A	uc010xfg.1	+	2	1059	c.606G>A	c.(604-606)ACG>ACA	p.T202T	NFATC1_uc002lnc.1_Silent_p.T202T|NFATC1_uc010xff.1_Silent_p.T202T|NFATC1_uc002lnd.2_Silent_p.T202T|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Silent_p.T202T|NFATC1_uc010xfi.1_Silent_p.T189T|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Silent_p.T189T|NFATC1_uc002lng.2_Silent_p.T189T|NFATC1_uc010xfk.1_Silent_p.T189T	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	202	Trans-activation domain A (TAD-A).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CCCCCCAGACGTCGCCATGGC	0.697													16	168					0	0	0	0	A	77170881	A	A	77170881	2	1	65	1	0	0	0	0	0	0	0	1	10415	1132	40	1		1	NFATC1	18	77170881	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	9177776	77170881	906367	503	13334											
KCNG2	26251	broad.mit.edu	37	chr18	77624217	77624217	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctcttcgcctgcgtgtccGtgtccttcgtggccgtcacg	2	12	12	15	6	2	0	1	0	1	0	6	0	4	0	4	1	2	1	4	1	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr18:77624217G>A	uc010xfl.1	+	1	550	c.550G>A	c.(550-552)GTG>ATG	p.V184M		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	184	Helical; Name=Segment S1; (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CTGCGTGTCCGTGTCCTTCGT	0.458													3	20					0	0	0	0	A	77624217	A	A	77624217	3	1	65	1	0	0	0	0	1	0	0	0	8067	1145	40	1	552	1	KCNG2	18	77624217	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	453336	77624217	453031	504	13335											
MIER2	54531	broad.mit.edu	37	chr19	308884	308886	+	In_Frame_Del	DEL	GTA	-	-																															cgctccgacttcttccacagGtagtagtactcgacacactc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:308884_308886delGTA	uc002lok.1	-	11	1033_1035	c.1024_1026delTAC	c.(1024-1026)TACdel	p.Y342del		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	342	SANT.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTTCCACAGGTAGTAGTACTCG	0.67													---	---	---								-	308886	-	-	308884	7	5	65	1	0	1	0	1	0	0	0	0	9634	1256	44	0	627	0	MIER2	19	308884	In_Frame_Del	DEL	GTA	TCGA-CN-5369-01A-01D-1434-08		308884	58820099	505	13336											
THEG	51298	broad.mit.edu	37	chr19	375832	375832	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcattgtccaggtcctggcGttcggggtctgtgacccgcc	3	11	14	13	3	1	1	0	1	1	0	4	1	3	1	4	4	1	2	4	4	0	2	rs151319374		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:375832G>A	uc002lol.2	-	1	178	c.139C>T	c.(139-141)CGC>TGC	p.R47C	THEG_uc002lom.2_Missense_Mutation_p.R47C	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1	47					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTCCTGGCGTTCGGGGTCT	0.677													13	105					0	0	0	0	A	375832	A	A	375832	3	1	65	1	0	0	0	0	1	0	0	0	15923	1145	40	1	1032	1	THEG	19	375832	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	66948	375832	58753151	506	13337											
TMPRSS9	360200	broad.mit.edu	37	chr19	2422029	2422030	+	Frame_Shift_Ins	INS	-	T	T																															ccagccccttcccatgtctcINSccccctcgaccacaaggatg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:2422029_2422030insT	uc010xgx.1	+	13	2230_2231	c.2230_2231insT	c.(2230-2232)CCCfs	p.P744fs		NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	744	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCATGTCTCCCCCCTCGACC	0.663													---	---	---								T	2422030	T	T	2422029	7	5	65	1	0	1	1	0	0	0	0	0	16319	855	30	0	2280	0	TMPRSS9	19	2422029	Frame_Shift_Ins	INS	-	TCGA-CN-5369-01A-01D-1434-08	2046197	2422029	56706954	507	13338											
GIPC3	126326	broad.mit.edu	37	chr19	3586543	3586543	+	Frame_Shift_Del	DEL	G	-	-																															gtggacatgcagaagctcctGgggggtcagataggcctgga																								rs8113232	byFrequency	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:3586543delG	uc002lyd.3	+	2	303	c.276delG	c.(274-276)CTGfs	p.L92fs		NM_133261	NP_573568	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	92										breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAAGCTCCTGGGGGGTCAGA	0.577											OREG0025154	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	3586543	-	-	3586543	7	5	65	1	0	1	0	1	0	0	0	0	6431	1335	47	0	282	0	GIPC3	19	3586543	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	1164514	3586543	55542440	508	13339											
C19orf10	56005	broad.mit.edu	37	chr19	4660713	4660713	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtactcaatctcagcgccccGcacctctgccttgaactgtg	7	10	8	16	2	3	1	2	1	2	0	4	1	3	1	4	0	4	2	4	0	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:4660713G>A	uc002may.2	-	4	406	c.337C>T	c.(337-339)CGG>TGG	p.R113W		NM_019107	NP_061980	Q969H8	CS010_HUMAN	hypothetical protein LOC56005 precursor	113						ER-Golgi intermediate compartment|extracellular region					0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.015)		TCAGCGCCCCGCACCTCTGCC	0.627													8	103					0	0	0	0	A	4660713	A	A	4660713	3	1	65	1	0	0	0	0	1	0	0	0	1917	1086	38	1	196	1	C19orf10	19	4660713	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1074170	4660713	54468270	509	13340											
C3	718	broad.mit.edu	37	chr19	6713251	6713251	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaagacttccccaccaggtCttctgctcgggggttctgca	7	10	10	14	1	3	1	0	0	3	1	5	1	4	1	3	3	2	3	3	3	1	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:6713251C>T	uc002mfm.2	-	9	1014	c.952G>A	c.(952-954)GAC>AAC	p.D318N		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	318					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CCCACCAGGTCTTCTGCTCGG	0.617													6	70					0	0	0	0	T	6713251	T	T	6713251	3	4	65	1	0	0	0	0	1	0	0	0	2214	913	32	2	4171	2	C3	19	6713251	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2052538	6713251	52415732	510	13341											
FBN3	84467	broad.mit.edu	37	chr19	8181655	8181655	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtggccttggtcacaaacGcgggggttctcttcacactc	7	10	11	13	2	3	0	2	0	1	0	5	0	3	0	1	4	1	1	1	4	1	3	rs138173924	by1000genomes	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:8181655G>A	uc002mjf.2	-	28	3636	c.3615C>T	c.(3613-3615)CGC>CGT	p.R1205R		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1205	EGF-like 17.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGTCACAAACGCGGGGGTTCT	0.592													12	118					0	0	0	0	A	8181655	A	A	8181655	2	1	65	1	0	0	0	0	0	0	0	1	5736	1074	38	1		1	FBN3	19	8181655	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1468404	8181655	50947328	511	13342											
MUC16	94025	broad.mit.edu	37	chr19	8974003	8974003	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtccctcagcagggtgatgTactctgaggatgtggggtct	6	12	15	8	0	3	2	1	2	2	0	4	3	4	3	1	4	2	2	1	4	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:8974003T>C	uc002mkp.2	-	76	42872	c.42668A>G	c.(42667-42669)TAC>TGC	p.Y14223C	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.Y1023C|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGGGTGATGTACTCTGAGGA	0.517													2	8					0	0	0	0	C	8974003	C	C	8974003	3	2	65	1	0	0	0	0	1	0	0	0	10026	1638	57	5	891	5	MUC16	19	8974003	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	792348	8974003	50154980	512	13343											
ZNF266	10781	broad.mit.edu	37	chr19	9524481	9524481	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atagggcctctctccactgtGagttcgtgcatgcttagtaa	8	13	10	10	1	1	1	0	1	1	0	4	1	2	1	2	1	2	4	2	1	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:9524481G>C	uc002mll.2	-	4	1386	c.1120C>G	c.(1120-1122)CAC>GAC	p.H374D	ZNF266_uc002mlm.2_Missense_Mutation_p.H374D|ZNF266_uc002mln.2_Missense_Mutation_p.H374D|ZNF266_uc002mlo.2_Missense_Mutation_p.H374D|ZNF266_uc010dwp.2_Missense_Mutation_p.H374D|ZNF266_uc010dwq.2_Missense_Mutation_p.H374D	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	374	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTCCACTGTGAGTTCGTGCA	0.448													13	153					0	0	0	0	C	9524481	C	C	9524481	3	2	65	1	0	0	0	0	1	0	0	0	17872	1290	45	2	533	2	ZNF266	19	9524481	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	550478	9524481	49604502	513	13344											
DNM2	1785	broad.mit.edu	37	chr19	10893656	10893656	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctacattggcgtggtgaacCgcagccagaaggatattgag	11	8	14	8	2	0	3	0	2	0	1	0	4	0	4	2	3	3	2	2	3	4	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:10893656C>T	uc002mps.1	+	6	873	c.709C>T	c.(709-711)CGC>TGC	p.R237C	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Missense_Mutation_p.R237C|DNM2_uc002mpv.1_Missense_Mutation_p.R237C|DNM2_uc002mpu.1_Missense_Mutation_p.R237C|DNM2_uc010dxl.1_Missense_Mutation_p.R237C|DNM2_uc002mpw.2_5'UTR	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	237					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CGTGGTGAACCGCAGCCAGAA	0.597													9	94					0	0	0	0	T	10893656	T	T	10893656	3	4	65	1	0	0	0	0	1	0	0	0	4694	652	23	1	731	1	DNM2	19	10893656	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1369175	10893656	48235327	514	13345											
CARM1	10498	broad.mit.edu	37	chr19	11030598	11030598	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgctgcattcagggctggtCcacggcctggctttctggtt	4	13	13	11	1	2	0	1	0	1	0	3	0	3	0	2	5	2	5	2	5	0	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:11030598C>T	uc002mpz.2	+	10	1278	c.1152C>T	c.(1150-1152)GTC>GTT	p.V384V	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_Silent_p.V167V	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	384					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						CAGGGCTGGTCCACGGCCTGG	0.592													4	53					0	0	0	0	T	11030598	T	T	11030598	2	4	65	1	0	0	0	0	0	0	0	1	2667	842	30	2		2	CARM1	19	11030598	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	136942	11030598	48098385	515	13346											
ZNF439	90594	broad.mit.edu	37	chr19	11978597	11978597	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccatgaaagaactcacactgGagagaaaccgtatgaatgta	17	7	9	8	1	1	4	1	2	0	2	1	6	1	5	2	1	2	2	2	1	6	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:11978597G>C	uc002mss.2	+	3	841	c.713G>C	c.(712-714)GGA>GCA	p.G238A	ZNF439_uc002msr.2_Missense_Mutation_p.G102A	NM_152262	NP_689475	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ACTCACACTGGAGAGAAACCG	0.368													15	187					0	0	0	0	C	11978597	C	C	11978597	3	2	65	1	0	0	0	0	1	0	0	0	17978	1174	41	2	723	2	ZNF439	19	11978597	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	947999	11978597	47150386	516	13347											
MAST1	22983	broad.mit.edu	37	chr19	12978714	12978714	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcccagctccgaccccgCgggatccctggatgcacggg	5	4	14	18	5	0	0	0	0	0	0	2	3	2	2	6	4	2	2	6	4	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:12978714C>T	uc002mvm.2	+	20	2617	c.2489C>T	c.(2488-2490)GCG>GTG	p.A830V		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	830					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						TCCGACCCCGCGGGATCCCTG	0.711													6	48					0	0	0	0	T	12978714	T	T	12978714	3	4	65	1	0	0	0	0	1	0	0	0	9377	768	27	1	2567	1	MAST1	19	12978714	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1000117	12978714	46150269	517	13348											
BRD4	23476	broad.mit.edu	37	chr19	15374334	15374334	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccaaactcctgagcatcaCggtactcacgggcctccagt	10	7	8	16	2	2	1	2	1	0	0	4	1	4	1	4	2	3	2	4	2	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:15374334C>T	uc002nar.2	-	7	1460	c.1238G>A	c.(1237-1239)CGT>CAT	p.R413H	BRD4_uc002nas.2_Missense_Mutation_p.R413H|BRD4_uc002nat.3_Missense_Mutation_p.R413H|BRD4_uc002nau.3_Missense_Mutation_p.R413H	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	413	Bromo 2.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			CTGAGCATCACGGTACTCACG	0.537			T	NUT|C15orf55	lethal midline carcinoma of young people								8	70					0	0	0	0	T	15374334	T	T	15374334	3	4	65	1	0	0	0	0	1	0	0	0	1509	536	19	1	2921	1	BRD4	19	15374334	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2395620	15374334	43754649	518	13349											
PDCD2L	84306	broad.mit.edu	37	chr19	34912527	34912527	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaaaggatatttgagtttCagcttatgccagcactggtc	10	12	10	9	0	1	1	1	1	0	0	2	2	1	2	2	2	3	3	2	2	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:34912527C>T	uc002nvj.2	+	6	934	c.901C>T	c.(901-903)CAG>TAG	p.Q301*		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	301						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			ATTTGAGTTTCAGCTTATGCC	0.453													28	283					0	0	0	0	T	34912527	T	T	34912527	4	4	65	1	0	0	0	0	0	1	0	0	11674	827	29	2	923	2	PDCD2L	19	34912527	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	19538193	34912527	24216456	519	13350											
TMEM147	10430	broad.mit.edu	37	chr19	36037660	36037660	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccggcaagggagagtacaaGatcatggttgctgccctggg	9	7	16	9	1	1	2	1	0	0	2	1	3	1	2	2	4	3	4	2	4	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:36037660G>C	uc002oaj.1	+	4	391	c.294G>C	c.(292-294)AAG>AAC	p.K98N	uc010eec.1_5'Flank|uc002oag.2_5'Flank|TMEM147_uc002oai.1_Missense_Mutation_p.K49N|TMEM147_uc002oak.1_Missense_Mutation_p.R8T	NM_032635	NP_116024	Q9BVK8	TM147_HUMAN	transmembrane protein 147	98						endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GAGAGTACAAGATCATGGTTG	0.582													6	105					0	0	0	0	C	36037660	C	C	36037660	3	2	65	1	0	0	0	0	1	0	0	0	16127	933	33	2	308	2	TMEM147	19	36037660	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1125133	36037660	23091323	520	13351											
PSENEN	55851	broad.mit.edu	37	chr19	36237739	36237739	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttcaccatacccctgggCaccccctgacaacttctgca	8	9	5	19	0	2	1	1	1	1	0	3	1	3	1	6	1	3	2	6	1	2	3	rs148274462		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:36237739C>T	uc002obi.1	+	4	501	c.297C>T	c.(295-297)GGC>GGT	p.G99G	TMEM149_uc010eej.2_5'Flank|U2AF1L4_uc002obh.1_5'Flank|U2AF1L4_uc002obe.2_5'Flank|U2AF1L4_uc002obf.2_5'Flank|U2AF1L4_uc002obg.2_5'Flank|PSENEN_uc002obj.1_Silent_p.G99G|PSENEN_uc002obk.1_Intron|LIN37_uc002obm.2_5'Flank	NM_172341	NP_758844	Q9NZ42	PEN2_HUMAN	presenilin enhancer 2	99	Lumenal (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	aspartic-type endopeptidase activity|protein binding			ovary(2)	2	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TACCCCTGGGCACCCCCTGAC	0.592													16	82					0	0	0	0	T	36237739	T	T	36237739	2	4	65	1	0	0	0	0	0	0	0	1	12714	697	25	4		4	PSENEN	19	36237739	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	200079	36237739	22891244	521	13352											
SIPA1L3	23094	broad.mit.edu	37	chr19	38591746	38591746	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaaggccggccagagctccGaggaggagatgtacaacaat	13	4	14	10	2	0	2	0	0	0	2	1	5	1	3	3	4	3	3	3	4	4	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:38591746G>A	uc002ohk.2	+	6	2418	c.1909G>A	c.(1909-1911)GAG>AAG	p.E637K		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	637	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCAGAGCTCCGAGGAGGAGAT	0.607													5	37					0	0	0	0	A	38591746	A	A	38591746	3	1	65	1	0	0	0	0	1	0	0	0	14396	1059	37	1	1923	1	SIPA1L3	19	38591746	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2354007	38591746	20537237	522	13353											
KCNK6	9424	broad.mit.edu	37	chr19	38817967	38817967	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggacgatcgggtggacaTcctgggcccccagccggagt	7	6	16	12	3	0	1	0	1	0	0	2	5	1	4	4	5	1	0	4	5	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:38817967T>C	uc002oic.2	+	3	976	c.866T>C	c.(865-867)ATC>ACC	p.I289T	KCNK6_uc002oid.2_Missense_Mutation_p.I155T	NM_004823	NP_004814	Q9Y257	KCNK6_HUMAN	potassium channel, subfamily K, member 6	289	Cytoplasmic (Potential).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)	1	all_cancers(60;5.83e-07)		Lung(45;0.00047)|LUSC - Lung squamous cell carcinoma(53;0.000613)		Ibutilide(DB00308)|Quinidine(DB00908)	CGGGTGGACATCCTGGGCCCC	0.662													12	105					0	0	0	0	C	38817967	C	C	38817967	3	2	65	1	0	0	0	0	1	0	0	0	8109	1435	50	5	876	5	KCNK6	19	38817967	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	226221	38817967	20311016	523	13354											
PLEKHG2	64857	broad.mit.edu	37	chr19	39911453	39911453	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacttgggtctcctcgacctCgagatgctagaagttttacc	8	12	9	12	2	1	2	0	0	1	2	4	4	1	2	3	1	2	2	3	1	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:39911453C>G	uc010xuz.1	+	13	1685	c.1360C>G	c.(1360-1362)CGA>GGA	p.R454G	PLEKHG2_uc010xuy.1_Missense_Mutation_p.R395G|PLEKHG2_uc002olj.2_Missense_Mutation_p.R454G|PLEKHG2_uc010xva.1_Missense_Mutation_p.R261G	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	454					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TCCTCGACCTCGAGATGCTAG	0.582													23	204					0	0	0	0	G	39911453	G	G	39911453	3	3	65	1	0	0	0	0	1	0	0	0	12124	876	31	3	1406	3	PLEKHG2	19	39911453	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1093486	39911453	19217530	524	13355											
PRX	57716	broad.mit.edu	37	chr19	40901949	40901949	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcttcacctctggtgcCttcggaagatgcacgtcggg	6	9	14	12	3	2	1	1	0	1	1	4	2	2	2	2	4	3	3	2	4	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:40901949C>A	uc002onr.2	-	7	2579	c.2310G>T	c.(2308-2310)AAG>AAT	p.K770N	PRX_uc002onq.2_Missense_Mutation_p.K631N|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	770	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCTCTGGTGCCTTCGGAAGAT	0.592													54	239					1.0442e-30	1.16063e-30	1	0	A	40901949	A	A	40901949	3	1	65	1	0	0	0	0	1	0	0	0	12704	680	24	4	2079	4	PRX	19	40901949	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	990496	40901949	18227034	525	13356											
DEDD2	162989	broad.mit.edu	37	chr19	42713983	42713983	+	Frame_Shift_Del	DEL	G	-	-																															tccgccgctgccgcttggttGggggggagcctgaggggaaa																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:42713983delG	uc002osu.1	-	4	526	c.458delC	c.(457-459)CCAfs	p.P153fs	DEDD2_uc002osv.1_RNA|DEDD2_uc002osw.1_Frame_Shift_Del_p.P148fs|DEDD2_uc002osx.1_Frame_Shift_Del_p.Q37fs|DEDD2_uc002osy.1_Frame_Shift_Del_p.P153fs|DEDD2_uc010eid.2_RNA	NM_133328	NP_579874	Q8WXF8	DEDD2_HUMAN	death effector domain-containing  DNA binding	153					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity				0		Prostate(69;0.0704)				CCGCTTGGTTGGGGGGGAGCC	0.662													---	---	---								-	42713983	-	-	42713983	7	5	65	1	0	1	0	1	0	0	0	0	4402	1348	47	0	530	0	DEDD2	19	42713983	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	1812034	42713983	16415000	526	13357											
CEACAM1	634	broad.mit.edu	37	chr19	43025447	43025447	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atgatcgtcttgactgtggtCctgttgcagccagtgactga	7	13	12	9	1	1	4	0	4	1	0	3	4	2	4	2	1	2	2	2	1	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:43025447C>G	uc002otv.2	-	4	1043	c.930G>C	c.(928-930)AGG>AGC	p.R310S	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|CEACAM1_uc010eii.2_RNA|CEACAM1_uc002otw.2_Missense_Mutation_p.R310S|CEACAM1_uc010eij.2_Missense_Mutation_p.R310S|CEACAM1_uc002otx.2_Missense_Mutation_p.R310S|CEACAM1_uc002oty.2_Missense_Mutation_p.R310S|CEACAM1_uc002otz.2_Missense_Mutation_p.R310S|CEACAM1_uc010eik.2_Intron|CEACAM1_uc002oua.2_Missense_Mutation_p.R310S|CEACAM1_uc002oub.2_Missense_Mutation_p.R310S|CEACAM1_uc002ouc.2_Missense_Mutation_p.R310S	NM_001712	NP_001703	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion	310	Ig-like C2-type 2.|Extracellular (Potential).				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				ovary(1)|central_nervous_system(1)	2		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	TGACTGTGGTCCTGTTGCAGC	0.448													13	238					0	0	0	0	G	43025447	G	G	43025447	3	3	65	1	0	0	0	0	1	0	0	0	3202	854	30	2	771	2	CEACAM1	19	43025447	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	311464	43025447	16103536	527	13358											
PSG6	5675	broad.mit.edu	37	chr19	43585208	43585208	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatatataattatttgaccGtctactacatatgatgtaat	14	16	4	7	1	1	2	0	2	1	0	1	2	1	2	2	0	2	1	2	0	8	9	rs148293206	by1000genomes	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:43585208G>A	uc002ovi.2	-	2	348	c.255C>T	c.(253-255)GAC>GAT	p.D85D	PSG6_uc010xwk.1_Intron|PSG2_uc002ovr.2_Silent_p.D85D|PSG2_uc002ovq.3_Silent_p.D85D|PSG2_uc010eiq.1_Silent_p.D85D|PSG2_uc002ovs.3_Silent_p.D85D|PSG2_uc002ovt.3_Silent_p.D85D			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	85	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				TTATTTGACCGTCTACTACAT	0.443													29	533					0	0	0	0	A	43585208	A	A	43585208	2	1	65	1	0	0	0	0	0	0	0	1	12721	1136	40	1		1	PSG6	19	43585208	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	559761	43585208	15543775	528	13359											
IRGQ	126298	broad.mit.edu	37	chr19	44099016	44099016	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccggaggcgctctagctcctCgcagccgtcgctgctgccgc	3	7	13	18	6	1	0	0	0	1	0	4	1	2	1	4	2	4	5	4	2	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:44099016C>T	uc002oww.2	-	1	593	c.475G>A	c.(475-477)GAG>AAG	p.E159K	IRGQ_uc010eiv.2_Missense_Mutation_p.E159K|ZNF576_uc002owy.2_5'Flank|ZNF576_uc002owz.2_5'Flank|SRRM5_uc002oxb.2_5'Flank	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	159	Potential.						protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				TCTAGCTCCTCGCAGCCGTCG	0.667													7	33					0	0	0	0	T	44099016	T	T	44099016	3	4	65	1	0	0	0	0	1	0	0	0	7878	893	31	1	1404	1	IRGQ	19	44099016	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	513808	44099016	15029967	529	13360											
ZFP112	7771	broad.mit.edu	37	chr19	44832114	44832114	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagtgtggactctctgatgAccttgaagatatgctctctg	8	14	10	9	0	2	4	0	3	2	1	4	5	2	5	1	1	1	1	1	1	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:44832114A>G	uc010ejj.2	-	5	2327	c.2214T>C	c.(2212-2214)GGT>GGC	p.G738G	ZFP112_uc002ozc.3_Silent_p.G732G|ZFP112_uc010xwy.1_Silent_p.G755G|ZFP112_uc010xwz.1_Silent_p.G737G	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	738	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CTCTCTGATGACCTTGAAGAT	0.458													23	450					0	0	0	0	G	44832114	G	G	44832114	2	3	65	1	0	0	0	0	0	0	0	1	17705	262	10	5		5	ZFP112	19	44832114	Silent	SNP	A	TCGA-CN-5369-01A-01D-1434-08	733098	44832114	14296869	530	13361											
PVR	5817	broad.mit.edu	37	chr19	45153219	45153219	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgggcgggatgcccaataCgagccaggtgccagggttcc	7	6	15	13	2	0	0	0	0	0	0	1	2	1	1	5	4	4	1	5	4	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:45153219C>T	uc002ozm.2	+	3	865	c.566C>T	c.(565-567)ACG>ATG	p.T189M	PVR_uc010ejs.2_Missense_Mutation_p.T189M|PVR_uc010xxb.1_Missense_Mutation_p.T189M|PVR_uc010xxc.1_Missense_Mutation_p.T189M|PVR_uc002ozn.2_Missense_Mutation_p.T134M	NM_006505	NP_006496	P15151	PVR_HUMAN	poliovirus receptor isoform alpha	189	Extracellular (Potential).|Ig-like C2-type 1.				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity				0	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		ATGCCCAATACGAGCCAGGTG	0.632													18	86					0	0	0	0	T	45153219	T	T	45153219	3	4	65	1	0	0	0	0	1	0	0	0	12902	536	19	1	576	1	PVR	19	45153219	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	321105	45153219	13975764	531	13362											
BCAM	4059	broad.mit.edu	37	chr19	45322440	45322440	+	Frame_Shift_Del	DEL	G	-	-																															aaactcagctggagccaattGgggggcagcgtaagggacct																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:45322440delG	uc002ozu.2	+	11	1508	c.1464delG	c.(1462-1464)TTGfs	p.L488fs	BCAM_uc002ozt.1_Frame_Shift_Del_p.L488fs	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	488	Extracellular (Potential).|Ig-like C2-type 3.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				GGAGCCAATTGGGGGGCAGCG	0.597													---	---	---								-	45322440	-	-	45322440	7	5	65	1	0	1	0	1	0	0	0	0	1346	1339	47	0	1506	0	BCAM	19	45322440	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	169221	45322440	13806543	532	13363											
STRN4	29888	broad.mit.edu	37	chr19	47231911	47231911	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccatccacagtgcaccgccGagggtctggagccccttccc	6	6	10	19	2	1	0	0	0	1	0	3	2	3	1	7	2	2	1	7	2	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:47231911G>A	uc002pfl.2	-	7	1036	c.1003C>T	c.(1003-1005)CGG>TGG	p.R335W	STRN4_uc002pfm.2_Missense_Mutation_p.R335W|STRN4_uc010xyf.1_RNA|STRN4_uc010xyg.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	335						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		GTGCACCGCCGAGGGTCTGGA	0.612													10	68					0	0	0	0	A	47231911	A	A	47231911	3	1	65	1	0	0	0	0	1	0	0	0	15397	1057	37	1	1323	1	STRN4	19	47231911	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1909471	47231911	11897072	533	13364											
EHD2	30846	broad.mit.edu	37	chr19	48244287	48244287	+	Frame_Shift_Del	DEL	G	-	-																															agcaccgaggtgggcgtgcaGgggggcgcttttgagggcac																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:48244287delG	uc002phj.3	+	6	1480	c.1230delG	c.(1228-1230)CAGfs	p.Q410fs	EHD2_uc010xyu.1_Frame_Shift_Del_p.Q274fs|EHD2_uc010xyv.1_Frame_Shift_Del_p.Q93fs	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	410					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		TGGGCGTGCAGGGGGGCGCTT	0.677													---	---	---								-	48244287	-	-	48244287	7	5	65	1	0	1	0	1	0	0	0	0	5000	991	35	0	1248	0	EHD2	19	48244287	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	1012376	48244287	10884696	534	13365											
GYS1	2997	broad.mit.edu	37	chr19	49473096	49473096	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttggacagcgccatgtggCgcgcagacatatagtactag	10	8	12	11	3	0	1	0	0	0	1	0	2	0	2	2	2	2	2	2	2	4	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:49473096C>T	uc002plp.2	-	15	2067	c.1826G>A	c.(1825-1827)CGC>CAC	p.R609H	GYS1_uc010xzy.1_Missense_Mutation_p.R242H|GYS1_uc010emm.2_Missense_Mutation_p.R545H|GYS1_uc010xzz.1_Missense_Mutation_p.R529H	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	609					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		CGCCATGTGGCGCGCAGACAT	0.612													10	110					0	0	0	0	T	49473096	T	T	49473096	3	4	65	1	0	0	0	0	1	0	0	0	6951	768	27	1	395	1	GYS1	19	49473096	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1228809	49473096	9655887	535	13366											
FCGRT	2217	broad.mit.edu	37	chr19	50017242	50017242	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgggcccgcagcagtacctGagctacaatagcctgcgggg	8	6	14	13	2	0	1	0	1	0	0	0	1	0	1	3	3	6	4	3	3	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:50017242G>C	uc002poe.2	+	3	663	c.177G>C	c.(175-177)CTG>CTC	p.L59L	FCGRT_uc002pod.2_RNA|FCGRT_uc002pog.2_Silent_p.L59L|FCGRT_uc002pof.1_5'UTR|FCGRT_uc010yax.1_Silent_p.L59L|FCGRT_uc002poh.1_5'Flank	NM_001136019	NP_001129491	P55899	FCGRN_HUMAN	Fc fragment of IgG, receptor, transporter, alpha	59	Extracellular (Potential).|Alpha-1.				antigen processing and presentation|female pregnancy|immune response	integral to membrane|MHC class I protein complex	IgG binding|receptor activity			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00291)|GBM - Glioblastoma multiforme(134;0.0156)		AGCAGTACCTGAGCTACAATA	0.642													30	167					0	0	0	0	C	50017242	C	C	50017242	2	2	65	1	0	0	0	0	0	0	0	1	5818	1277	45	2		2	FCGRT	19	50017242	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	544146	50017242	9111741	536	13367											
SIGLEC11	114132	broad.mit.edu	37	chr19	50462016	50462016	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctccaggaccccggggtctGagggctgggaggggcccacg	5	4	19	13	2	1	1	0	1	1	0	2	3	2	3	4	7	0	2	4	7	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:50462016G>A	uc010ybh.1	-	7	1338	c.1247C>T	c.(1246-1248)TCA>TTA	p.S416L	SIGLEC11_uc010ybi.1_Missense_Mutation_p.S416L	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	416	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		CCCGGGGTCTGAGGGCTGGGA	0.677													28	140					0	0	0	0	A	50462016	A	A	50462016	3	1	65	1	0	0	0	0	1	0	0	0	14372	1294	45	2	869	2	SIGLEC11	19	50462016	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	444774	50462016	8666967	537	13368											
SIGLEC10	89790	broad.mit.edu	37	chr19	51917032	51917032	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtgccgggagaacctgggCctcggggtttctgtctgagt	4	11	16	10	2	2	2	0	1	2	1	3	3	2	2	3	4	2	1	3	4	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:51917032C>T	uc002pwo.2	-	10	2371	c.1755G>A	c.(1753-1755)AGG>AGA	p.R585R	SIGLEC10_uc002pwp.2_Silent_p.R527R|SIGLEC10_uc002pwq.2_Silent_p.R432R|SIGLEC10_uc002pwr.2_Silent_p.R490R|SIGLEC10_uc010ycy.1_Silent_p.R400R|SIGLEC10_uc010ycz.1_Silent_p.R442R|SIGLEC10_uc010eow.2_Silent_p.R302R|SIGLEC10_uc002pws.1_Silent_p.R326R	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	585	Cytoplasmic (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AGAACCTGGGCCTCGGGGTTT	0.537													16	212					0	0	0	0	T	51917032	T	T	51917032	2	4	65	1	0	0	0	0	0	0	0	1	14371	738	26	4		4	SIGLEC10	19	51917032	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1455016	51917032	7211951	538	13369											
ZNF880	400713	broad.mit.edu	37	chr19	52887776	52887776	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcacaccttgcacgacatCagaaaattcatagtggagag	15	8	9	9	1	2	2	2	0	0	2	2	4	2	2	1	1	2	2	1	1	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:52887776C>T	uc002pzc.2	+	4	992	c.943C>T	c.(943-945)CAG>TAG	p.Q315*		NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	315	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TGCACGACATCAGAAAATTCA	0.423													7	59					0	0	0	0	T	52887776	T	T	52887776	4	4	65	1	0	0	0	0	0	1	0	0	18264	827	29	2	957	2	ZNF880	19	52887776	Nonsense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	970744	52887776	6241207	539	13370											
ZNF468	90333	broad.mit.edu	37	chr19	53344521	53344521	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagtatagtatgttttgcCagatatgaattatatgcgaa	14	15	9	3	1	0	3	0	2	0	1	0	4	0	3	1	0	2	3	1	0	9	8			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:53344521C>A	uc002qaf.2	-	4	1177	c.1026G>T	c.(1024-1026)CTG>CTT	p.L342L	ZNF468_uc002qae.2_Silent_p.L289L	NM_001008801	NP_001008801	Q5VIY5	ZN468_HUMAN	zinc finger protein ZNF468 isoform 2	342	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0358)		TATGTTTTGCCAGATATGAAT	0.383													23	260					1.50039e-11	1.63584e-11	1	0	A	53344521	A	A	53344521	2	1	65	1	0	0	0	0	0	0	0	1	17995	581	21	4		4	ZNF468	19	53344521	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	456745	53344521	5784462	540	13371											
LAIR2	3904	broad.mit.edu	37	chr19	55014149	55014149	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggccatgtctccacacctCactgctctcctgggcctagg	5	9	11	16	0	3	0	1	0	2	0	5	0	3	0	5	4	1	1	5	4	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:55014149C>T	uc002qgc.2	+	1	137	c.15C>T	c.(13-15)CTC>CTT	p.L5L	LAIR2_uc002qga.1_Intron|LAIR2_uc002qgb.1_Intron|LAIR2_uc002qgd.2_Silent_p.L5L|LAIR2_uc010erl.2_Silent_p.L5L	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like	5						extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		CTCCACACCTCACTGCTCTCC	0.627													12	133					0	0	0	0	T	55014149	T	T	55014149	2	4	65	1	0	0	0	0	0	0	0	1	8643	813	29	2		2	LAIR2	19	55014149	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1669628	55014149	4114834	541	13372											
LILRA2	11027	broad.mit.edu	37	chr19	55086049	55086049	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctggagctggtggtgacaGgtgagaggacactcaggagt	9	7	17	8	0	1	2	1	2	0	1	1	6	1	5	1	6	1	1	1	6	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:55086049G>T	uc002qgg.3	+	3	441	c.352G>T	c.(352-354)GGA>TGA	p.G118*	LILRA2_uc010ern.2_Nonsense_Mutation_p.G118*|LILRA2_uc002qgf.2_Nonsense_Mutation_p.G118*|LILRA2_uc010yfe.1_Nonsense_Mutation_p.G118*|LILRA2_uc010yff.1_Nonsense_Mutation_p.G106*|LILRA2_uc010ero.2_Nonsense_Mutation_p.G106*|LILRA2_uc010yfg.1_Nonsense_Mutation_p.G118*	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	118	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		GGTGGTGACAGGTGAGAGGAC	0.607													19	88					2.94398e-08	3.1336e-08	1	0	T	55086049	T	T	55086049	4	4	65	1	0	0	0	0	0	1	0	0	8826	1014	35	4	362	4	LILRA2	19	55086049	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	71900	55086049	4042934	542	13373											
NLRP5	126206	broad.mit.edu	37	chr19	56569758	56569758	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcctttgcctgtcccacgtCtaacttacagataattgggt	8	13	9	11	1	1	1	0	0	1	1	2	1	2	1	3	2	3	0	3	2	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:56569758C>G	uc002qmj.2	+	14	3452	c.3452C>G	c.(3451-3453)TCT>TGT	p.S1151C	NLRP5_uc002qmi.2_Missense_Mutation_p.S1132C	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	1151						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGTCCCACGTCTAACTTACAG	0.483													7	56					0	0	0	0	G	56569758	G	G	56569758	3	3	65	1	0	0	0	0	1	0	0	0	10534	913	32	2	3506	2	NLRP5	19	56569758	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1483709	56569758	2559225	543	13374											
ZNF543	125919	broad.mit.edu	37	chr19	57839434	57839434	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaaaattcctataaatgtGaggaatgcgggaaagtgttt	16	11	11	3	1	0	2	0	1	0	1	1	4	1	4	1	2	1	1	1	2	7	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:57839434G>A	uc002qoi.1	+	4	949	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	202	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTATAAATGTGAGGAATGCGG	0.413													12	153					0	0	0	0	A	57839434	A	A	57839434	3	1	65	1	0	0	0	0	1	0	0	0	18043	1291	45	2	618	2	ZNF543	19	57839434	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1269676	57839434	1289549	544	13375											
ZNF416	55659	broad.mit.edu	37	chr19	58083744	58083744	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgaattttctggtgttcaaCgagggtatagctttgtctaa	9	16	11	5	1	3	1	1	1	2	0	3	2	3	1	0	2	2	3	0	2	5	7	rs147696919		TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:58083744C>T	uc002qpf.2	-	4	1699	c.1528G>A	c.(1528-1530)GTT>ATT	p.V510I	ZNF547_uc002qpm.3_Intron	NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	510	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		TGGTGTTCAACGAGGGTATAG	0.428													9	171					0	0	0	0	T	58083744	T	T	58083744	3	4	65	1	0	0	0	0	1	0	0	0	17960	536	19	1	260	1	ZNF416	19	58083744	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	244310	58083744	1045239	545	13376											
ZSCAN18	65982	broad.mit.edu	37	chr19	58601680	58601680	+	Translation_Start_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgactgtctagccagggacaAggtggctccaaaggagaggt	11	7	15	8	0	1	2	0	1	1	1	2	4	2	3	2	5	1	1	2	5	3	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:58601680A>T	uc002qri.2	-	2	264	c.-45T>A	c.(-47--43)CCTTG>CCATG		ZSCAN18_uc002qrj.3_Translation_Start_Site|ZSCAN18_uc010yhs.1_Intron|ZSCAN18_uc002qrh.2_Translation_Start_Site|ZSCAN18_uc010yht.1_Silent_p.P41P|ZSCAN18_uc002qrk.1_Translation_Start_Site|ZSCAN18_uc002qrl.2_Translation_Start_Site	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCCAGGGACAAGGTGGCTCCA	0.602													7	56					0	0	0	0	T	58601680	T	T	58601680	1	4	65	1	0	0	0	0	0	0	0	0	18297	59	3	5		5	ZSCAN18	19	58601680	Translation_Start_Site	SNP	A	TCGA-CN-5369-01A-01D-1434-08	517936	58601680	527303	546	13377											
ZBTB45	84878	broad.mit.edu	37	chr19	59028991	59028991	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgagggtctcaagcagagagCgtgagaagttctgcaggtgt	10	9	16	6	1	2	3	1	2	2	2	3	5	2	3	0	2	3	3	0	2	2	1	rs117819245	by1000genomes	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr19:59028991C>T	uc002qtd.2	-	2	342	c.50G>A	c.(49-51)CGC>CAC	p.R17H	ZBTB45_uc002qte.2_Missense_Mutation_p.R17H|ZBTB45_uc002qtf.2_Missense_Mutation_p.R17H	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		AAGCAGAGAGCGTGAGAAGTT	0.592											OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	58					0	0	0	0	T	59028991	T	T	59028991	3	4	65	1	0	0	0	0	1	0	0	0	17613	768	27	1	1493	1	ZBTB45	19	59028991	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	427311	59028991	99992	547	13378											
SLC4A11	83959	broad.mit.edu	37	chr20	3214613	3214613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcacccctgtcactgtggCggtgaccccttggatggtat	5	10	12	14	2	1	1	1	1	0	0	1	2	1	2	5	4	0	2	5	4	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:3214613C>T	uc002wig.2	-	5	655	c.607G>A	c.(607-609)GCC>ACC	p.A203T	SLC4A11_uc010zqe.1_Missense_Mutation_p.A230T|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.A187T	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	203	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						GTCACTGTGGCGGTGACCCCT	0.647													18	129					0	0	0	0	T	3214613	T	T	3214613	3	4	65	1	0	0	0	0	1	0	0	0	14716	768	27	1	2128	1	SLC4A11	20	3214613	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08		3214613	59810907	548	13379											
SLC23A2	9962	broad.mit.edu	37	chr20	4843461	4843461	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggctcccagcacaggatcCggaagggacgcaaagagggc	12	2	16	11	2	0	1	0	0	0	1	2	4	2	4	2	5	1	3	2	5	2	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:4843461C>T	uc002wlg.1	-	14	1824	c.1449G>A	c.(1447-1449)CCG>CCA	p.P483P	SLC23A2_uc010zqr.1_Silent_p.P368P|SLC23A2_uc002wlh.1_Silent_p.P483P	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	483					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						GCACAGGATCCGGAAGGGACG	0.557													11	88					0	0	0	0	T	4843461	T	T	4843461	2	4	65	1	0	0	0	0	0	0	0	1	14527	639	23	1		1	SLC23A2	20	4843461	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1628848	4843461	58182059	549	13380											
RALGAPA2	57186	broad.mit.edu	37	chr20	20493692	20493692	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggtccttctgtgggtgtctGaaggtaggagatgagggtgc	6	11	18	6	1	2	3	0	2	2	1	3	4	3	3	1	5	1	1	1	5	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:20493692G>A	uc002wrz.2	-	32	4464	c.4321C>T	c.(4321-4323)CAG>TAG	p.Q1441*	RALGAPA2_uc010gcx.2_Nonsense_Mutation_p.Q1145*|RALGAPA2_uc010zsg.1_Nonsense_Mutation_p.Q889*|RALGAPA2_uc002wsa.1_Nonsense_Mutation_p.Q213*	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1441					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						GTGGGTGTCTGAAGGTAGGAG	0.507													5	38					0	0	0	0	A	20493692	A	A	20493692	4	1	65	1	0	0	0	0	0	1	0	0	13079	1299	45	2	1332	2	RALGAPA2	20	20493692	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	15650231	20493692	42531828	550	13381											
RALGAPA2	57186	broad.mit.edu	37	chr20	20493763	20493763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gacttctgaacacctcaaagGacagctcggagccttccaca	12	7	8	14	1	2	1	1	1	1	0	4	4	3	3	3	2	3	1	3	2	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:20493763G>A	uc002wrz.2	-	32	4393	c.4250C>T	c.(4249-4251)TCC>TTC	p.S1417F	RALGAPA2_uc010gcx.2_Missense_Mutation_p.S1121F|RALGAPA2_uc010zsg.1_Missense_Mutation_p.S865F|RALGAPA2_uc002wsa.1_Missense_Mutation_p.S189F	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1417					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						CACCTCAAAGGACAGCTCGGA	0.552													4	48					0	0	0	0	A	20493763	A	A	20493763	3	1	65	1	0	0	0	0	1	0	0	0	13079	1174	41	2	1403	2	RALGAPA2	20	20493763	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	71	20493763	42531757	551	13382											
SPAG4	6676	broad.mit.edu	37	chr20	34208803	34208803	+	Frame_Shift_Del	DEL	C	-	-																															catttgtctccccagaatgaCcccccagctgcctttcccaa																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:34208803delC	uc002xdb.1	+	12	1290	c.1173delC	c.(1171-1173)GACfs	p.D391fs	SPAG4_uc010zvi.1_Frame_Shift_Del_p.D314fs	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	391	SUN.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			CCCAGAATGACCCCCCAGCTG	0.577													---	---	---								-	34208803	-	-	34208803	7	5	65	1	0	1	0	1	0	0	0	0	15046	506	18	0	1219	0	SPAG4	20	34208803	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08	13715040	34208803	28816717	552	13383											
EPB41L1	2036	broad.mit.edu	37	chr20	34809829	34809829	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaaggatcgagaagcgaaTcatcattactggggatgaag	15	7	13	6	2	2	2	2	1	0	1	3	7	2	4	0	3	2	0	0	3	5	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:34809829T>A	uc002xfb.2	+	20	2654	c.2483T>A	c.(2482-2484)ATC>AAC	p.I828N	EPB41L1_uc002xeu.2_Missense_Mutation_p.I726N|EPB41L1_uc002xev.2_Missense_Mutation_p.I827N|EPB41L1_uc002xew.2_Missense_Mutation_p.I719N|EPB41L1_uc002xex.2_Missense_Mutation_p.I648N|EPB41L1_uc002xey.2_Missense_Mutation_p.I578N|EPB41L1_uc002xez.2_Missense_Mutation_p.I726N|EPB41L1_uc010gfq.2_Missense_Mutation_p.I926N	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	828	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					GAGAAGCGAATCATCATTACT	0.542													11	70					0	0	0	0	A	34809829	A	A	34809829	3	1	65	1	0	0	0	0	1	0	0	0	5176	1435	50	5	2557	5	EPB41L1	20	34809829	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	601026	34809829	28215691	553	13384											
DHX35	60625	broad.mit.edu	37	chr20	37634810	37634810	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgatagtggccaccaatgtgGcagaaacctctatcacaatc	13	9	8	11	0	2	2	1	1	1	1	3	2	2	2	3	2	1	1	3	2	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:37634810G>A	uc002xjh.2	+	12	1044	c.1033G>A	c.(1033-1035)GCA>ACA	p.A345T	DHX35_uc010zwa.1_Missense_Mutation_p.A190T|DHX35_uc010zwb.1_Missense_Mutation_p.A190T|DHX35_uc010zwc.1_Missense_Mutation_p.A314T	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	345	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CACCAATGTGGCAGAAACCTC	0.408													30	663					0	0	0	0	A	37634810	A	A	37634810	3	1	65	1	0	0	0	0	1	0	0	0	4530	1203	42	4	1079	4	DHX35	20	37634810	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2824981	37634810	25390710	554	13385											
MAFB	9935	broad.mit.edu	37	chr20	39316607	39316607	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgagtttctcgcacttgaccTtgtaggcgtctctctcgcgg	4	13	11	13	5	3	1	0	1	3	0	6	2	3	1	1	2	0	3	1	2	1	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:39316607T>G	uc002xji.2	-	1	1270	c.884A>C	c.(883-885)AAG>ACG	p.K295T		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	295					negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				GCACTTGACCTTGTAGGCGTC	0.597			T	IGH@	MM								9	145					0	0	0	0	G	39316607	G	G	39316607	3	3	65	1	0	0	0	0	1	0	0	0	9209	1609	56	5	91	5	MAFB	20	39316607	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	1681797	39316607	23708913	555	13386											
PI3	5266	broad.mit.edu	37	chr20	43804666	43804666	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgccccattatcttgatcCggtgcgccatgttgaatccc	6	12	8	15	2	1	2	0	2	1	0	3	2	3	2	6	1	2	1	6	1	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:43804666C>T	uc002xng.2	+	2	268	c.244C>T	c.(244-246)CGG>TGG	p.R82W		NM_002638	NP_002629	P19957	ELAF_HUMAN	elafin preproprotein	82	WAP.				copulation	proteinaceous extracellular matrix	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				TATCTTGATCCGGTGCGCCAT	0.507													9	102					0	0	0	0	T	43804666	T	T	43804666	3	4	65	1	0	0	0	0	1	0	0	0	11925	643	23	1	250	1	PI3	20	43804666	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	4488059	43804666	19220854	556	13387											
SEMG2	6407	broad.mit.edu	37	chr20	43851591	43851591	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtatttctatccaaactgaaGagaaaatacatggcaagtct	16	11	7	7	0	2	2	0	1	2	1	3	3	3	2	1	1	2	2	1	1	8	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:43851591G>C	uc010ggz.2	+	2	1375	c.1318G>C	c.(1318-1320)GAG>CAG	p.E440Q	SEMG2_uc002xnk.2_Missense_Mutation_p.E440Q|SEMG2_uc002xnl.2_Intron	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	440	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CCAAACTGAAGAGAAAATACA	0.378													8	91					0	0	0	0	C	43851591	C	C	43851591	3	2	65	1	0	0	0	0	1	0	0	0	14110	943	33	2	1324	2	SEMG2	20	43851591	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	46925	43851591	19173929	557	13388											
WFDC3	140686	broad.mit.edu	37	chr20	44404233	44404233	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaacttttggacaatcacCgccccgccctgtgggaacaa	11	7	9	14	2	1	1	1	0	0	1	1	3	1	3	4	2	2	0	4	2	4	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:44404233C>T	uc002xpf.1	-	6	586	c.502G>A	c.(502-504)GGT>AGT	p.G168S	WFDC3_uc002xpj.1_RNA|WFDC3_uc002xph.1_RNA|WFDC3_uc010ghh.1_RNA	NM_080614	NP_542181	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3 precursor	168	WAP 4.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GGACAATCACCGCCCCGCCCT	0.532													6	99					0	0	0	0	T	44404233	T	T	44404233	3	4	65	1	0	0	0	0	1	0	0	0	17421	652	23	1	201	1	WFDC3	20	44404233	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	552642	44404233	18621287	558	13389											
PREX1	57580	broad.mit.edu	37	chr20	47324916	47324916	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcagggcactctggaccGcggggtggtctgggtgcttg	3	9	18	11	2	2	0	0	0	2	0	2	1	2	1	2	6	2	3	2	6	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:47324916G>A	uc002xtw.1	-	6	688	c.665C>T	c.(664-666)GCG>GTG	p.A222V		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	222	DH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			ACTCTGGACCGCGGGGTGGTC	0.582													35	391					0	0	0	0	A	47324916	A	A	47324916	3	1	65	1	0	0	0	0	1	0	0	0	12538	1087	38	1	4454	1	PREX1	20	47324916	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2920683	47324916	15700604	559	13390											
TMEM189-UBE2V1	387522	broad.mit.edu	37	chr20	48744600	48744600	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atgacatgccagtcctgcagGagggtgacccagcgtggcag	9	6	15	11	1	0	2	0	2	0	0	1	3	1	3	3	3	3	2	3	3	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:48744600G>C	uc002xvf.2	-	5	764	c.603C>G	c.(601-603)CTC>CTG	p.L201L	TMEM189_uc010zyq.1_RNA|TMEM189_uc002xvg.2_Silent_p.L201L|TMEM189_uc010gif.2_Silent_p.L198L|TMEM189_uc010zyp.1_Silent_p.L126L	NM_199203	NP_954673	Q13404	UB2V1_HUMAN	TMEM189-UBE2V1 readthrough transcript	Error:Variant_position_missing_in_Q13404_after_alignment					cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein K63-linked ubiquitination|regulation of DNA repair|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-UEV1A complex|ubiquitin ligase complex	acid-amino acid ligase activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(9;8.29e-07)			AGTCCTGCAGGAGGGTGACCC	0.587													12	52					0	0	0	0	C	48744600	C	C	48744600	2	2	65	1	0	0	0	0	0	0	0	1	16178	1161	41	2		2	TMEM189-UBE2V1	20	48744600	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1419684	48744600	14280920	560	13391											
ZNF217	7764	broad.mit.edu	37	chr20	52188284	52188284	+	Nonstop_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttccccctaattagtgaatCaagtttttttgtcatttggt	8	20	6	7	0	2	1	2	1	0	0	3	1	3	1	2	1	0	1	2	1	4	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:52188284C>G	uc002xwq.3	-	4	3417	c.3146G>C	c.(3145-3147)TGA>TCA	p.*1049S		NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	1049					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			ATTAGTGAATCAAGTTTTTTT	0.328													12	149					0	0	0	0	G	52188284	G	G	52188284	4	3	65	1	0	0	0	0	0	0	0	0	17839	837	29	2	4	2	ZNF217	20	52188284	Nonstop_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3443684	52188284	10837236	561	13392											
CDH26	60437	broad.mit.edu	37	chr20	58587630	58587630	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaccccggctacctacctCacgtctacagcgaggaaggg	10	6	11	14	3	2	1	1	1	1	0	2	3	2	2	4	3	4	1	4	3	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:58587630C>T	uc002ybe.2	+	18	2644	c.2344C>T	c.(2344-2346)CAC>TAC	p.H782Y	CDH26_uc002ybf.1_Intron|CDH26_uc010zzy.1_RNA|CDH26_uc002ybg.2_Missense_Mutation_p.H273Y|CDH26_uc002ybh.2_Missense_Mutation_p.H115Y|CDH26_uc002ybi.2_Missense_Mutation_p.H74Y	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	Error:Variant_position_missing_in_Q8IXH8_after_alignment					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CTACCTACCTCACGTCTACAG	0.552													19	180					0	0	0	0	T	58587630	T	T	58587630	3	4	65	1	0	0	0	0	1	0	0	0	3125	826	29	2	2436	2	CDH26	20	58587630	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6399346	58587630	4437890	562	13393											
CDH4	1002	broad.mit.edu	37	chr20	60508054	60508054	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccccacagccatggtcctgCtgtttgtcatgtggatgaag	7	11	11	12	0	1	1	1	1	0	0	2	2	2	2	4	2	2	2	4	2	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:60508054C>T	uc002ybn.1	+	14	2265	c.2251C>T	c.(2251-2253)CTG>TTG	p.L751L	CDH4_uc002ybp.1_Silent_p.L677L	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	751	Helical; (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CATGGTCCTGCTGTTTGTCAT	0.592													4	44					0	0	0	0	T	60508054	T	T	60508054	2	4	65	1	0	0	0	0	0	0	0	1	3127	796	28	4		4	CDH4	20	60508054	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1920424	60508054	2517466	563	13394											
DIDO1	11083	broad.mit.edu	37	chr20	61511065	61511065	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctgcctcccttcgaaagtCtggtttctgtattcgtggcc	4	15	9	13	2	3	0	0	0	3	0	6	1	4	0	3	2	1	2	3	2	2	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr20:61511065C>G	uc002ydr.1	-	16	6507	c.6243G>C	c.(6241-6243)CAG>CAC	p.Q2081H	DIDO1_uc002yds.1_Missense_Mutation_p.Q2081H	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	2081					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTTCGAAAGTCTGGTTTCTGT	0.677													31	403					0	0	0	0	G	61511065	G	G	61511065	3	3	65	1	0	0	0	0	1	0	0	0	4544	912	32	2	483	2	DIDO1	20	61511065	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1003011	61511065	1514455	564	13395											
KRTAP10-6	386674	broad.mit.edu	37	chr21	46011396	46011396	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggaggaggcagaggcacCacaggaggggacgggcacgc	11	0	20	10	2	0	1	0	0	0	1	0	5	0	5	1	8	0	4	1	8	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr21:46011396C>A	uc002zfm.2	-	1	991	c.970G>T	c.(970-972)GGT>TGT	p.G324C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198688	NP_941961	P60371	KR106_HUMAN	keratin associated protein 10-6	324	29 X 5 AA repeats of C-C-X(3).					keratin filament					0						GCAGAGGCACCACAGGAGGGG	0.692													13	110					4.36969e-10	4.72318e-10	1	0	A	46011396	A	A	46011396	3	1	65	1	0	0	0	0	1	0	0	0	8552	594	21	4	131	4	KRTAP10-6	21	46011396	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08		46011396	2118499	565	13396											
MCM3AP	8888	broad.mit.edu	37	chr21	47666772	47666772	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgtctccacagcatcaatgGcaccatcactgagggcgcca	10	7	10	14	1	3	1	2	1	1	0	4	1	3	1	3	2	1	2	3	2	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr21:47666772G>A	uc002zir.1	-	21	4355	c.4319C>T	c.(4318-4320)GCC>GTC	p.A1440V	MCM3APAS_uc002zim.2_Intron|MCM3APAS_uc002zin.2_Intron|MCM3AP_uc002zio.1_5'UTR|MCM3AP_uc002zip.1_Missense_Mutation_p.A181V|MCM3AP_uc002ziq.1_Missense_Mutation_p.A367V|MCM3APAS_uc002zis.1_Intron	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	1440					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					AGCATCAATGGCACCATCACT	0.577													16	197					0	0	0	0	A	47666772	A	A	47666772	3	1	65	1	0	0	0	0	1	0	0	0	9441	1203	42	4	1655	4	MCM3AP	21	47666772	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1655376	47666772	463123	566	13397											
CDC45	8318	broad.mit.edu	37	chr22	19495334	19495336	+	In_Frame_Del	DEL	CTC	-	-																															aagttccaggccatggacatCtccttgaaggagaatttgcg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr22:19495334_19495336delCTC	uc002zpr.2	+	12	1078_1080	c.1002_1004delCTC	c.(1000-1005)ATCTCC>ATC	p.S335del	CDC45_uc011agz.1_In_Frame_Del_p.S330del|CDC45_uc011aha.1_In_Frame_Del_p.S367del|CDC45_uc002zps.2_In_Frame_Del_p.S335del|CDC45_uc002zpt.2_In_Frame_Del_p.S289del	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	335					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						CCATGGACATCTCCTTGAAGGAG	0.453													---	---	---								-	19495336	-	-	19495334	7	5	65	1	0	1	0	1	0	0	0	0	3096	903	32	0	1148	0	CDC45	22	19495334	In_Frame_Del	DEL	CTC	TCGA-CN-5369-01A-01D-1434-08		19495334	31809232	567	13398											
ZNF74	7625	broad.mit.edu	37	chr22	20761221	20761221	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgtggttccccccagagctgGcaggaatttctccctgggga	6	9	13	13	1	1	1	0	0	1	1	3	3	2	3	4	5	1	3	4	5	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr22:20761221G>A	uc010gsm.2	+	6	2110	c.1898G>A	c.(1897-1899)GGC>GAC	p.G633D	ZNF74_uc002zsg.2_Missense_Mutation_p.G562D|ZNF74_uc002zsh.2_Missense_Mutation_p.G633D|ZNF74_uc002zsi.2_Missense_Mutation_p.G562D|ZNF74_uc010gsn.2_Missense_Mutation_p.G562D	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	633					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CCCAGAGCTGGCAGGAATTTC	0.458													8	59					0	0	0	0	A	20761221	A	A	20761221	3	1	65	1	0	0	0	0	1	0	0	0	18194	1203	42	4	1916	4	ZNF74	22	20761221	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1265887	20761221	30543345	568	13399											
CACNA1I	8911	broad.mit.edu	37	chr22	40075794	40075794	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagggggagctgaccatcaTcgacaacctgtcgggctcca	9	6	14	12	2	1	1	1	1	0	0	4	4	2	3	3	4	2	2	3	4	1	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr22:40075794T>C	uc003ayc.2	+	33	5462	c.5462T>C	c.(5461-5463)ATC>ACC	p.I1821T	CACNA1I_uc003ayd.2_Missense_Mutation_p.I1786T|CACNA1I_uc003aye.2_Missense_Mutation_p.I1736T|CACNA1I_uc003ayf.2_Missense_Mutation_p.I1701T	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1821	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CTGACCATCATCGACAACCTG	0.617													3	23					0	0	0	0	C	40075794	C	C	40075794	3	2	65	1	0	0	0	0	1	0	0	0	2558	1435	50	5	5592	5	CACNA1I	22	40075794	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	19314573	40075794	11228772	569	13400											
MEI1	150365	broad.mit.edu	37	chr22	42154484	42154484	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggagggagctgctcgccaGagacagtactgcatcctgct	9	8	13	11	1	0	1	0	0	0	1	2	4	1	3	2	2	5	5	2	2	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr22:42154484G>A	uc003baz.1	+	18	2092	c.2067G>A	c.(2065-2067)CAG>CAA	p.Q689Q	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Silent_p.Q57Q|MEI1_uc003bbc.1_Silent_p.Q57Q|MEI1_uc010gym.1_Silent_p.Q57Q|MEI1_uc003bbd.1_5'UTR	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	689							binding			central_nervous_system(1)|skin(1)	2						CTGCTCGCCAGAGACAGTACT	0.582													6	44					0	0	0	0	A	42154484	A	A	42154484	2	1	65	1	0	0	0	0	0	0	0	1	9518	933	33	2		2	MEI1	22	42154484	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2078690	42154484	9150082	570	13401											
EFCAB6	64800	broad.mit.edu	37	chr22	43985982	43985982	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagatgggtcagctccccttCggtaagagaacatccacatt	11	9	9	12	1	1	2	1	0	0	2	4	3	3	2	3	2	2	2	3	2	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr22:43985982C>T	uc003bdy.1	-	24	3219	c.3004G>A	c.(3004-3006)GAA>AAA	p.E1002K	EFCAB6_uc003bdz.1_Missense_Mutation_p.E850K|EFCAB6_uc010gzi.1_Missense_Mutation_p.E850K|EFCAB6_uc010gzj.1_Missense_Mutation_p.E228K	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1002					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				AGCTCCCCTTCGGTAAGAGAA	0.408													22	193					0	0	0	0	T	43985982	T	T	43985982	3	4	65	1	0	0	0	0	1	0	0	0	4961	893	31	1	1537	1	EFCAB6	22	43985982	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1831498	43985982	7318584	571	13402											
SELO	83642	broad.mit.edu	37	chr22	50647025	50647025	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagggcgtgcaggccccagCgtggggaggaacgacattcg	9	4	17	11	4	0	0	0	0	0	0	1	3	0	2	2	5	3	1	2	5	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr22:50647025C>T	uc011arr.1	+	3	877	c.819C>T	c.(817-819)AGC>AGT	p.S273S	SELO_uc010hap.2_Silent_p.S84S|SELO_uc003bjy.2_5'UTR|SELO_uc003bjz.2_5'Flank	NM_031454	NP_113642	Q9BVL4	SELO_HUMAN	selenoprotein O	273											0		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		CAGGCCCCAGCGTGGGGAGGA	0.567													14	158					0	0	0	0	T	50647025	T	T	50647025	2	4	65	1	0	0	0	0	0	0	0	1	14083	767	27	1		1	SELO	22	50647025	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6661043	50647025	657541	572	13403											
SELO	83642	broad.mit.edu	37	chr22	50654267	50654267	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcctccctggaggagctgagGctggccttccggccccagat	5	7	14	15	1	0	2	0	1	0	1	2	4	2	4	6	5	1	2	6	5	0	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chr22:50654267G>A	uc011arr.1	+	6	1531	c.1473G>A	c.(1471-1473)AGG>AGA	p.R491R	SELO_uc010hap.2_Silent_p.R302R|SELO_uc003bjy.2_Silent_p.R171R|SELO_uc003bjz.2_Missense_Mutation_p.A244T	NM_031454	NP_113642	Q9BVL4	SELO_HUMAN	selenoprotein O	491											0		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		AGGAGCTGAGGCTGGCCTTCC	0.572													10	124					0	0	0	0	A	50654267	A	A	50654267	2	1	65	1	0	0	0	0	0	0	0	1	14083	1194	42	4		4	SELO	22	50654267	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	7242	50654267	650299	573	13404											
ASMTL	8623	broad.mit.edu	37	chrX	1546793	1546793	+	Frame_Shift_Del	DEL	C	-	-																															tctgagtgggctccgagccgCccccctccacgtcactgagg																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:1546793delC	uc004cpx.1	-	7	842	c.731delG	c.(730-732)GGCfs	p.G244fs	ASMTL_uc011mhe.1_Frame_Shift_Del_p.G168fs|ASMTL_uc004cpy.1_Frame_Shift_Del_p.G228fs|ASMTL_uc011mhf.1_Frame_Shift_Del_p.G186fs	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	244					melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTCCGAGCCGCCCCCCTCCAC	0.697													---	---	---								-	1546793	-	-	1546793	7	5	65	1	0	1	0	1	0	0	0	0	1048	739	26	0	1162	0	ASMTL	23	1546793	Frame_Shift_Del	DEL	C	TCGA-CN-5369-01A-01D-1434-08		1546793	153723767	574	13405											
CD99	4267	broad.mit.edu	37	chrX	2658839	2658839	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcagcgtactcttttagaGaaatagaagattgtcggcag	12	12	11	6	2	2	3	1	0	1	3	3	4	2	3	0	1	2	3	0	1	5	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:2658839G>A	uc004cqm.2	+	10	726	c.552G>A	c.(550-552)GAG>GAA	p.E184E	CD99_uc010nda.2_Silent_p.E168E|CD99_uc004cqn.2_RNA|CD99_uc004cqo.2_Silent_p.E183E	NM_002414	NP_002405	P14209	CD99_HUMAN	CD99 antigen isoform a precursor	184	Cytoplasmic (Potential).				cell adhesion	cytoplasm|integral to plasma membrane				skin(1)	1						CTCTTTTAGAGAAATAGAAGA	0.522													12	185					0	0	0	0	A	2658839	A	A	2658839	2	1	65	1	0	0	0	0	0	0	0	1	3065	933	33	2		2	CD99	23	2658839	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1112046	2658839	152611721	575	13406											
FRMPD4	9758	broad.mit.edu	37	chrX	12734553	12734553	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttatttttggagacttcGccttggatgatggtattagt	7	18	10	6	1	0	2	0	1	0	1	1	4	0	3	2	3	0	1	2	3	3	8			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:12734553G>A	uc004cuz.1	+	15	2481	c.1975G>A	c.(1975-1977)GCC>ACC	p.A659T	FRMPD4_uc011mij.1_Missense_Mutation_p.A651T	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	659					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TGGAGACTTCGCCTTGGATGA	0.483													38	402					0	0	0	0	A	12734553	A	A	12734553	3	1	65	1	0	0	0	0	1	0	0	0	6093	1087	38	1	2033	1	FRMPD4	23	12734553	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	10075714	12734553	142536007	576	13407											
PHKA2	5256	broad.mit.edu	37	chrX	18959765	18959765	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caatttctttagatgtcgacGctcttggcagcatggagaac	10	12	10	9	2	2	2	0	0	2	2	3	4	2	2	0	2	2	3	0	2	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:18959765G>A	uc004cyv.3	-	8	1176	c.746C>T	c.(745-747)GCG>GTG	p.A249V	PHKA2_uc010nfh.1_RNA|PHKA2_uc010nfi.1_Missense_Mutation_p.A158V	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	249					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					AGATGTCGACGCTCTTGGCAG	0.428													6	96					0	0	0	0	A	18959765	A	A	18959765	3	1	65	1	0	0	0	0	1	0	0	0	11899	1087	38	1	3065	1	PHKA2	23	18959765	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	6225212	18959765	136310795	577	13408											
YY2	404281	broad.mit.edu	37	chrX	21875588	21875588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcccttgatttcaatttgcGcacacacttgcgcatccaca	9	13	5	14	2	1	1	1	1	0	0	3	1	3	1	2	0	2	2	2	0	1	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:21875588G>A	uc011mjp.1	+	1	986	c.986G>A	c.(985-987)CGC>CAC	p.R329H	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Missense_Mutation_p.R547H|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	329	Mediates transcriptional repression.|C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						TTCAATTTGCGCACACACTTG	0.532													58	461					0	0	0	0	A	21875588	A	A	21875588	3	1	65	1	0	0	0	0	1	0	0	0	17577	1087	38	1	988	1	YY2	23	21875588	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2915823	21875588	133394972	578	13409											
DMD	1756	broad.mit.edu	37	chrX	31164450	31164450	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccaaccactcggagcagcaTaggctgactgctgtcggacc	9	6	12	14	2	0	1	0	1	0	0	2	3	0	3	3	3	4	4	3	3	2	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:31164450T>C	uc004dda.1	-	76	11123	c.10879A>G	c.(10879-10881)ATG>GTG	p.M3627V	DMD_uc004dcq.1_Missense_Mutation_p.M898V|DMD_uc004dcr.1_Missense_Mutation_p.M1047V|DMD_uc004dcs.1_Missense_Mutation_p.M1057V|DMD_uc004dct.1_Missense_Mutation_p.M1167V|DMD_uc004dcu.1_Missense_Mutation_p.M1167V|DMD_uc004dcv.1_Missense_Mutation_p.M1154V|DMD_uc004dcw.2_Missense_Mutation_p.M2283V|DMD_uc004dcx.2_Missense_Mutation_p.M2286V|DMD_uc004dcz.2_Missense_Mutation_p.M3504V|DMD_uc004dcy.1_Missense_Mutation_p.M3623V|DMD_uc004ddb.1_Missense_Mutation_p.M3619V|DMD_uc004dcm.1_Missense_Mutation_p.M559V|DMD_uc004dcn.1_Missense_Mutation_p.M546V|DMD_uc004dco.1_Missense_Mutation_p.M559V|DMD_uc004dcp.1_Missense_Mutation_p.M546V|DMD_uc011mkb.1_Missense_Mutation_p.M449V	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3627					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CGGAGCAGCATAGGCTGACTG	0.498													12	96					0	0	0	0	C	31164450	C	C	31164450	3	2	65	1	0	0	0	0	1	0	0	0	4602	1406	49	5	280	5	DMD	23	31164450	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	9288862	31164450	124106110	579	13410											
DMD	1756	broad.mit.edu	37	chrX	32862971	32862972	+	In_Frame_Ins	INS	-	TTT	TTT																															actcttgtggatcctttttcINSttttggctgagaacaaaaca																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:32862971_32862972insTTT	uc004dda.1	-	4	436_437	c.192_193insAAA	c.(190-195)insAAA	p.64_65insK	DMD_uc004dcz.2_5'UTR|DMD_uc004dcy.1_In_Frame_Ins_p.60_61insK|DMD_uc004ddb.1_In_Frame_Ins_p.56_57insK|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_In_Frame_Ins_p.56_57insK|DMD_uc010ngq.1_RNA|DMD_uc010ngr.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	64_65	CH 1.|Actin-binding.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GATCCTTTTTCTTTTGGCTGAG	0.396													---	---	---								TTT	32862972	TTT	TTT	32862971	7	5	65	1	0	1	1	0	0	0	0	0	4602	922	32	0	11411	0	DMD	23	32862971	In_Frame_Ins	INS	-	TCGA-CN-5369-01A-01D-1434-08	1698521	32862971	122407589	580	13411											
FAM47A	158724	broad.mit.edu	37	chrX	34149420	34149420	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtctccggaggctccgggcGgagactggacaccggagtct	7	6	16	12	4	2	1	0	0	2	1	4	5	3	4	3	6	0	1	3	6	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:34149420G>A	uc004ddg.2	-	1	1009	c.976C>T	c.(976-978)CGC>TGC	p.R326C		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	326										ovary(4)|central_nervous_system(1)	5						GGCTCCGGGCGGAGACTGGAC	0.617													4	48					0	0	0	0	A	34149420	A	A	34149420	3	1	65	1	0	0	0	0	1	0	0	0	5601	1116	39	1	1403	1	FAM47A	23	34149420	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1286449	34149420	121121140	581	13412											
FAM47C	442444	broad.mit.edu	37	chrX	37028001	37028001	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagagccccccaagacacgCgtatctcatctccgcccaga	10	5	7	19	3	2	3	1	0	2	3	4	3	2	3	6	0	1	1	6	0	2	1	rs149060980	by1000genomes	TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:37028001C>T	uc004ddl.1	+	1	1532	c.1518C>T	c.(1516-1518)CGC>CGT	p.R506R		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	506										ovary(3)	3						CCAAGACACGCGTATCTCATC	0.617													10	178					0	0	0	0	T	37028001	T	T	37028001	2	4	65	1	0	0	0	0	0	0	0	1	5603	755	27	1		1	FAM47C	23	37028001	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2878581	37028001	118242559	582	13413											
CYBB	1536	broad.mit.edu	37	chrX	37655262	37655262	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggcatcactggagttgTcatcacgctgtgcctcatat	8	11	11	11	1	4	0	4	0	0	0	4	1	4	1	1	3	1	4	1	3	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:37655262T>C	uc004ddr.2	+	6	603	c.542T>C	c.(541-543)GTC>GCC	p.V181A	CYBB_uc011mke.1_RNA|CYBB_uc011mkf.1_Missense_Mutation_p.V149A|CYBB_uc011mkg.1_Intron	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	181	Helical; (Potential).|Ferric oxidoreductase.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						ACTGGAGTTGTCATCACGCTG	0.388													10	151					0	0	0	0	C	37655262	C	C	37655262	3	2	65	1	0	0	0	0	1	0	0	0	4150	1667	58	5	564	5	CYBB	23	37655262	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	627261	37655262	117615298	583	13414											
USP9X	8239	broad.mit.edu	37	chrX	41075704	41075704	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatggacacaatagaccaaGatgatgagttgataagatat	18	9	10	4	0	0	6	0	3	0	3	0	8	0	7	1	1	0	1	1	1	6	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:41075704G>C	uc004dfb.2	+	35	6517	c.5884G>C	c.(5884-5886)GAT>CAT	p.D1962H	USP9X_uc004dfc.2_Missense_Mutation_p.D1962H	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1962					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						AATAGACCAAGATGATGAGTT	0.393													14	185					0	0	0	0	C	41075704	C	C	41075704	3	2	65	1	0	0	0	0	1	0	0	0	17158	942	33	2	6018	2	USP9X	23	41075704	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3420442	41075704	114194856	584	13415											
SLC38A5	92745	broad.mit.edu	37	chrX	48319088	48319088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcgagcagcacggccaggcGcacacagaggatgagcgggt	10	2	17	12	5	0	2	0	1	0	1	0	4	0	3	1	4	3	3	1	4	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:48319088G>A	uc010nid.2	-	14	1193	c.1015C>T	c.(1015-1017)CGC>TGC	p.R339C	SLC38A5_uc004djk.3_Missense_Mutation_p.R288C	NM_033518	NP_277053	Q8WUX1	S38A5_HUMAN	solute carrier family 38, member 5	339	Helical; (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				ovary(3)	3						ACGGCCAGGCGCACACAGAGG	0.582													9	82					0	0	0	0	A	48319088	A	A	48319088	3	1	65	1	0	0	0	0	1	0	0	0	14671	1087	38	1	419	1	SLC38A5	23	48319088	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	7243384	48319088	106951472	585	13416											
TBC1D25	4943	broad.mit.edu	37	chrX	48417690	48417690	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcccgacccgaggagttgCgcctgcggatctatcatggc	6	9	12	14	4	3	0	1	0	2	0	4	4	3	2	3	3	2	1	3	3	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:48417690C>T	uc004dka.1	+	5	772	c.661C>T	c.(661-663)CGC>TGC	p.R221C	TBC1D25_uc011mly.1_Missense_Mutation_p.R163C|TBC1D25_uc004dkb.1_5'UTR|TBC1D25_uc011mlz.1_5'UTR|TBC1D25_uc011mma.1_5'UTR|TBC1D25_uc004dkc.1_5'UTR|TBC1D25_uc011mmb.1_Missense_Mutation_p.R225C|TBC1D25_uc011mmc.1_5'UTR|TBC1D25_uc011mmd.1_5'UTR	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	221						intracellular	Rab GTPase activator activity			ovary(1)	1						CGAGGAGTTGCGCCTGCGGAT	0.582													4	41					0	0	0	0	T	48417690	T	T	48417690	3	4	65	1	0	0	0	0	1	0	0	0	15681	768	27	1	679	1	TBC1D25	23	48417690	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	98602	48417690	106852870	586	13417											
GNL3L	54552	broad.mit.edu	37	chrX	54574764	54574764	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttctggggaactattgcCgccttggtgaagtgcgcacc	6	10	15	10	2	1	1	0	1	1	0	1	2	1	2	3	4	3	2	3	4	3	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:54574764C>T	uc004dth.1	+	9	872	c.733C>T	c.(733-735)CGC>TGC	p.R245C	GNL3L_uc004dti.2_RNA	NM_019067	NP_061940	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3	245					ribosome biogenesis	nucleolus	GTP binding			ovary(1)	1						GAACTATTGCCGCCTTGGTGA	0.542													5	75					0	0	0	0	T	54574764	T	T	54574764	3	4	65	1	0	0	0	0	1	0	0	0	6575	652	23	1	763	1	GNL3L	23	54574764	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6157074	54574764	100695796	587	13418											
FOXR2	139628	broad.mit.edu	37	chrX	55650821	55650822	+	Frame_Shift_Ins	INS	-	C	C																															aatttcacccgacagcatttINScccctttttctggacagctc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:55650821_55650822insC	uc004duo.2	+	1	989_990	c.677_678insC	c.(676-678)TTCfs	p.F226fs		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	226	Fork-head.				embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						CGACAGCATTTCCCCTTTTTCT	0.51													---	---	---								C	55650822	C	C	55650821	7	5	65	1	0	1	1	0	0	0	0	0	6066	1783	62	0	679	0	FOXR2	23	55650821	Frame_Shift_Ins	INS	-	TCGA-CN-5369-01A-01D-1434-08	1076057	55650821	99619739	588	13419											
FAM123B	139285	broad.mit.edu	37	chrX	63412011	63412011	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcctctaattccacctcttCttcctcttcttcctcctcgt	3	18	1	19	1	5	0	0	0	5	0	11	0	10	0	6	0	0	0	6	0	1	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:63412011C>G	uc004dvo.2	-	2	1429	c.1156G>C	c.(1156-1158)GAA>CAA	p.E386Q		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	386	Glu-rich.				Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						tccacctcttcttcctcttct	0.348													12	158					0	0	0	0	G	63412011	G	G	63412011	3	3	65	1	0	0	0	0	1	0	0	0	5451	922	32	2	2255	2	FAM123B	23	63412011	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	7761190	63412011	91858549	589	13420											
HEPH	9843	broad.mit.edu	37	chrX	65413477	65413477	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagataggcatcttggaatcCtgggtgaggaatttttaaat	13	13	11	4	0	1	2	0	1	1	1	2	4	2	4	1	4	0	1	1	4	6	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:65413477C>A	uc011moz.1	+	8	1435	c.1375C>A	c.(1375-1377)CTG>ATG	p.L459M	HEPH_uc004dwn.2_Missense_Mutation_p.L459M|HEPH_uc004dwo.2_Missense_Mutation_p.L189M|HEPH_uc010nkr.2_Missense_Mutation_p.L459M|HEPH_uc011mpa.1_Missense_Mutation_p.L459M	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	456	Extracellular (Potential).|Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						TCTTGGAATCCTGGGTGAGGA	0.418													11	79					4.68919e-08	4.94926e-08	1	0	A	65413477	A	A	65413477	3	1	65	1	0	0	0	0	1	0	0	0	7093	680	24	4	1558	4	HEPH	23	65413477	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2001466	65413477	89857083	590	13421											
EDA	1896	broad.mit.edu	37	chrX	69255292	69255292	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcagtgcacacgcagcatcGagacgggcaagaccaactac	13	4	11	13	3	0	2	0	0	0	2	1	3	0	2	1	1	5	5	1	1	3	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:69255292G>A	uc004dxs.2	+	8	1251	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	EDA_uc004dxr.2_Missense_Mutation_p.E335K|EDA_uc011mpj.1_Missense_Mutation_p.E332K	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	337	Extracellular (Potential).				cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						ACGCAGCATCGAGACGGGCAA	0.552													9	58					0	0	0	0	A	69255292	A	A	69255292	3	1	65	1	0	0	0	0	1	0	0	0	4925	1059	37	1	1175	1	EDA	23	69255292	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3841815	69255292	86015268	591	13422											
KIF4A	24137	broad.mit.edu	37	chrX	69639936	69639936	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgaaagagatgtgcgatgtgGagcaggtgctgtcaaagaag	13	8	16	4	1	1	3	1	1	0	2	1	6	1	4	0	2	3	2	0	2	3	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:69639936G>A	uc004dyg.2	+	31	3647	c.3520G>A	c.(3520-3522)GAG>AAG	p.E1174K	KIF4A_uc010nkw.2_Missense_Mutation_p.E1174K	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	1174	Globular.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						GTGCGATGTGGAGCAGGTGCT	0.507													8	59					0	0	0	0	A	69639936	A	A	69639936	3	1	65	1	0	0	0	0	1	0	0	0	8342	1175	41	2	3638	2	KIF4A	23	69639936	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	384644	69639936	85630624	592	13423											
DLG3	1741	broad.mit.edu	37	chrX	69722041	69722041	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagggtgactcactggaagaGatttataacaaaatcaaaca	18	8	8	7	0	2	2	2	1	0	1	2	4	2	3	0	2	2	0	0	2	6	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:69722041G>C	uc004dyi.1	+	19	2704	c.2376G>C	c.(2374-2376)GAG>GAC	p.E792D	DLG3_uc004dyj.1_Missense_Mutation_p.E487D|DLG3_uc011mpn.1_Missense_Mutation_p.E340D	NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	792	Guanylate kinase-like.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)					CACTGGAAGAGATTTATAACA	0.443													4	52					0	0	0	0	C	69722041	C	C	69722041	3	2	65	1	0	0	0	0	1	0	0	0	4578	933	33	2	2738	2	DLG3	23	69722041	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	82105	69722041	85548519	593	13424											
ZMYM3	9203	broad.mit.edu	37	chrX	70472945	70472945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caagcaggtccagggctcccGaggatggagaagggccaggg	10	3	18	10	1	0	1	0	0	0	1	2	4	2	2	3	6	1	2	3	6	2	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:70472945G>A	uc004dzh.1	-	2	248	c.161C>T	c.(160-162)TCG>TTG	p.S54L	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.S54L|ZMYM3_uc004dzj.1_Missense_Mutation_p.S54L|ZMYM3_uc011mpu.1_5'Flank|ZMYM3_uc004dzk.3_Missense_Mutation_p.S54L|ZMYM3_uc004dzl.3_Missense_Mutation_p.S54L|ZMYM3_uc004dzm.3_Missense_Mutation_p.S54L	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	54					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CAGGGCTCCCGAGGATGGAGA	0.607											OREG0019858	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	51					0	0	0	0	A	70472945	A	A	70472945	3	1	65	1	0	0	0	0	1	0	0	0	17768	1059	37	1	4065	1	ZMYM3	23	70472945	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	750904	70472945	84797615	594	13425											
KIAA2022	340533	broad.mit.edu	37	chrX	73960813	73960813	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattttttcctggtgtttttCtgagaagagctttggttcat	6	20	10	5	0	2	2	1	1	1	2	3	4	3	2	1	2	1	3	1	2	1	7			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:73960813C>G	uc004eby.2	-	3	4196	c.3579G>C	c.(3577-3579)CAG>CAC	p.Q1193H		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1193					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TGGTGTTTTTCTGAGAAGAGC	0.428													17	257					0	0	0	0	G	73960813	G	G	73960813	3	3	65	1	0	0	0	0	1	0	0	0	8308	912	32	2	979	2	KIAA2022	23	73960813	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3487868	73960813	81309747	595	13426											
ATRX	546	broad.mit.edu	37	chrX	76937131	76937131	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatcatcatcttctatatcaGaagaagatgaggatgtaatg	15	12	9	5	0	5	4	3	1	2	3	5	6	5	5	0	1	0	1	0	1	5	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:76937131G>C	uc004ecp.3	-	9	3849	c.3617C>G	c.(3616-3618)TCT>TGT	p.S1206C	ATRX_uc004ecq.3_Missense_Mutation_p.S1168C|ATRX_uc004eco.3_Missense_Mutation_p.S991C|ATRX_uc004ecr.2_Missense_Mutation_p.S1138C|ATRX_uc010nlx.1_Missense_Mutation_p.S1177C|ATRX_uc010nly.1_Missense_Mutation_p.S1151C	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1206	Poly-Ser.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTCTATATCAGAAGAAGATGA	0.378			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						13	320					0	0	0	0	C	76937131	C	C	76937131	3	2	65	1	0	0	0	0	1	0	0	0	1210	942	33	2	3969	2	ATRX	23	76937131	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2976318	76937131	78333429	596	13427											
TAF9B	51616	broad.mit.edu	37	chrX	77395061	77395061	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttatccttcgcacttaccaaGgcatctctcggagcgttctt	7	14	7	13	3	2	0	0	0	2	0	6	1	3	1	2	2	2	3	2	2	3	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:77395061G>T	uc004eda.2	-	1	119	c.48C>A	c.(46-48)GCC>GCA	p.A16A		NM_015975	NP_057059	Q9HBM6	TAF9B_HUMAN	transcription associated factor 9B	16					negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding				0						CACTTACCAAGGCATCTCTCG	0.657													15	222					4.14922e-12	4.53956e-12	1	0	T	77395061	T	T	77395061	2	4	65	1	0	0	0	0	0	0	0	1	15602	987	35	4		4	TAF9B	23	77395061	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	457930	77395061	77875499	597	13428											
BRWD3	254065	broad.mit.edu	37	chrX	79999689	79999689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatttcagcagagtgtccacGaagtgtagcaagaaggcgtc	13	8	12	8	2	1	2	1	0	0	2	3	3	2	2	1	1	2	3	1	1	5	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:79999689G>A	uc004edt.2	-	8	918	c.655C>T	c.(655-657)CGT>TGT	p.R219C	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_Missense_Mutation_p.R48C|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_5'UTR|BRWD3_uc004edr.2_5'UTR|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_5'UTR|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_5'UTR|BRWD3_uc004eea.2_5'UTR|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	219	WD 2.									ovary(4)	4						GAGTGTCCACGAAGTGTAGCA	0.403													12	174					0	0	0	0	A	79999689	A	A	79999689	3	1	65	1	0	0	0	0	1	0	0	0	1531	1058	37	1	4889	1	BRWD3	23	79999689	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2604628	79999689	75270871	598	13429											
PCDH11X	27328	broad.mit.edu	37	chrX	91134260	91134261	+	Frame_Shift_Del	DEL	AC	-	-																															ttcgaggtacctgtgtccgtAcacaccagaccggtaggtat																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:91134260_91134261delAC	uc004efk.1	+	2	3866_3867	c.3021_3022delAC	c.(3019-3024)GTACACfs	p.V1007fs	PCDH11X_uc004efl.1_Frame_Shift_Del_p.V1007fs|PCDH11X_uc004efo.1_Frame_Shift_Del_p.V1007fs|PCDH11X_uc010nmv.1_Frame_Shift_Del_p.V1007fs|PCDH11X_uc004efm.1_Frame_Shift_Del_p.V1007fs|PCDH11X_uc004efn.1_Frame_Shift_Del_p.V1007fs|PCDH11X_uc004efh.1_Frame_Shift_Del_p.V1007fs|PCDH11X_uc004efj.1_Frame_Shift_Del_p.V1007fs	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1007_1008	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTGTGTCCGTACACACCAGACC	0.406													---	---	---								-	91134261	-	-	91134260	7	5	65	1	0	1	0	1	0	0	0	0	11562	378	14	0	3027	0	PCDH11X	23	91134260	Frame_Shift_Del	DEL	AC	TCGA-CN-5369-01A-01D-1434-08	11134571	91134260	64136300	599	13430											
SYTL4	94121	broad.mit.edu	37	chrX	99956326	99956326	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttgctttcttcaactctCtgggaagaaataaaagaaaa	16	11	7	7	0	3	2	1	0	2	2	4	3	3	3	0	1	2	2	0	1	7	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:99956326C>T	uc004egd.3	-	6	683	c.327_splice	c.e6-1	p.I109_splice	SYTL4_uc010nnc.2_Splice_Site_p.I109_splice|SYTL4_uc004ege.3_Splice_Site_p.I109_splice|SYTL4_uc004egf.3_Splice_Site_p.I109_splice|SYTL4_uc004egg.3_Splice_Site_p.I109_splice	NM_080737	NP_542775	Q96C24	SYTL4_HUMAN	synaptotagmin-like 4						exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			ovary(2)	2					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTCAACTCTCTGGGAAGAAA	0.458													6	70					0	0	0	0	T	99956326	T	T	99956326	5	4	65	1	0	0	0	0	0	0	1	0	15551	927	32	2	1745	2	SYTL4	23	99956326	Splice_Site	SNP	C	TCGA-CN-5369-01A-01D-1434-08	8822066	99956326	55314234	600	13431											
RAB40AL	282808	broad.mit.edu	37	chrX	102192729	102192729	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcagccctctgtgcaatttCaacatcatagagtctttcac	10	13	6	12	0	6	1	4	0	2	1	6	1	6	1	1	0	3	1	1	0	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:102192729C>G	uc004ejs.2	+	1	530	c.483C>G	c.(481-483)TTC>TTG	p.F161L		NM_001031834	NP_001027004	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	161					protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			ovary(2)	2						TGTGCAATTTCAACATCATAG	0.592													6	100					0	0	0	0	G	102192729	G	G	102192729	3	3	65	1	0	0	0	0	1	0	0	0	13005	825	29	2	485	2	RAB40AL	23	102192729	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2236403	102192729	53077831	601	13432											
GLRA4	441509	broad.mit.edu	37	chrX	102979153	102979153	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagggatcgaggtccagaGagtcatcaggatattctcgg	10	9	15	7	2	3	1	2	0	1	1	6	6	4	4	1	5	0	0	1	5	1	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:102979153G>T	uc011mse.1	-	4	768	c.347C>A	c.(346-348)TCT>TAT	p.S116Y	GLRA4_uc010nou.2_Missense_Mutation_p.S116Y	NM_001024452	NP_001019623	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4 precursor	116	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity				0						GAGGTCCAGAGAGTCATCAGG	0.547													24	243					1.85244e-09	1.99201e-09	1	0	T	102979153	T	T	102979153	3	4	65	1	0	0	0	0	1	0	0	0	6494	942	33	2	1025	2	GLRA4	23	102979153	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	786424	102979153	52291407	602	13433											
NRK	203447	broad.mit.edu	37	chrX	105152976	105152976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagctcgggtgttcatgcCactacaggctcaggtgaagg	8	8	15	10	1	2	1	2	1	0	0	3	1	2	1	1	5	3	4	1	5	2	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:105152976C>T	uc004emd.2	+	13	1646	c.1343C>T	c.(1342-1344)CCA>CTA	p.P448L	NRK_uc010npc.1_Missense_Mutation_p.P116L	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	448	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GTGTTCATGCCACTACAGGCT	0.557										HNSCC(51;0.14)			10	70					0	0	0	0	T	105152976	T	T	105152976	3	4	65	1	0	0	0	0	1	0	0	0	10709	594	21	4	1393	4	NRK	23	105152976	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2173823	105152976	50117584	603	13434											
RNF128	79589	broad.mit.edu	37	chrX	106016281	106016281	+	Frame_Shift_Del	DEL	T	-	-																															ttgggtgaatcactattcaaTttttttcgtttctgtgtcct																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:106016281delT	uc004eml.2	+	2	873	c.623delT	c.(622-624)ATTfs	p.I208fs	RNF128_uc004emk.2_Frame_Shift_Del_p.I182fs	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	208	Helical; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						CACTATTCAATTTTTTTCGTT	0.388													---	---	---								-	106016281	-	-	106016281	7	5	65	1	0	1	0	1	0	0	0	0	13501	1493	52	0	1039	0	RNF128	23	106016281	Frame_Shift_Del	DEL	T	TCGA-CN-5369-01A-01D-1434-08	863305	106016281	49254279	604	13435											
PRPS1	5631	broad.mit.edu	37	chrX	106885676	106885676	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agggagaatatctctgagtgGaggaactgcactattgtctc	11	11	12	7	0	2	2	0	1	2	1	4	5	2	4	0	3	2	1	0	3	4	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:106885676G>T	uc004ene.3	+	4	691	c.486G>T	c.(484-486)TGG>TGT	p.W162C	PRPS1_uc010npg.2_Missense_Mutation_p.W129C|PRPS1_uc011msj.1_Intron	NM_002764	NP_002755	P60891	PRPS1_HUMAN	phosphoribosyl pyrophosphate synthetase 1	162					5-phosphoribose 1-diphosphate biosynthetic process|hypoxanthine biosynthetic process|nervous system development|nucleoside metabolic process|purine nucleotide biosynthetic process|pyrimidine nucleotide biosynthetic process|ribonucleoside monophosphate biosynthetic process|urate biosynthetic process	cytosol	ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(3)|large_intestine(1)	4						TCTCTGAGTGGAGGAACTGCA	0.433													21	203					2.37509e-13	2.60762e-13	1	0	T	106885676	T	T	106885676	3	4	65	1	0	0	0	0	1	0	0	0	12640	1183	41	2	500	2	PRPS1	23	106885676	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	869395	106885676	48384884	605	13436											
MID2	11043	broad.mit.edu	37	chrX	107084402	107084402	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaccgttgcctgcgggccacGcaccccaacaagaaaccttt	10	6	9	16	3	0	1	0	0	0	1	0	2	0	1	6	1	4	2	6	1	3	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:107084402G>A	uc004enl.2	+	2	1080	c.507G>A	c.(505-507)ACG>ACA	p.T169T	MID2_uc004enk.2_Silent_p.T169T	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	169	B box-type 1; degenerate.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						TGCGGGCCACGCACCCCAACA	0.552													8	72					0	0	0	0	A	107084402	A	A	107084402	2	1	65	1	0	0	0	0	0	0	0	1	9631	1074	38	1		1	MID2	23	107084402	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	198726	107084402	48186158	606	13437											
TEX13B	56156	broad.mit.edu	37	chrX	107224932	107224933	+	Frame_Shift_Del	DEL	CT	-	-																															ttccatctcagcatgtcccgCtctctctgcacctccgcaag																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:107224932_107224933delCT	uc004enn.1	-	2	518_519	c.425_426delAG	c.(424-426)GAGfs	p.E142fs		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	142										ovary(1)	1						GCATGTCCCGCTCTCTCTGCAC	0.589													---	---	---								-	107224933	-	-	107224932	7	5	65	1	0	1	0	1	0	0	0	0	15843	796	28	0	520	0	TEX13B	23	107224932	Frame_Shift_Del	DEL	CT	TCGA-CN-5369-01A-01D-1434-08	140530	107224932	48045628	607	13438											
KCNE1L	23630	broad.mit.edu	37	chrX	108868222	108868222	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggcggctcagaagggttcGcagccgctggctctcgctgc	5	7	15	14	4	2	1	1	0	1	1	4	1	2	1	1	4	2	6	1	4	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:108868222G>A	uc004eoh.2	-	1	172	c.28C>T	c.(28-30)CGA>TGA	p.R10*		NM_012282	NP_036414	Q9UJ90	KCE1L_HUMAN	potassium voltage-gated channel, Isk-related	10					regulation of heart contraction	voltage-gated potassium channel complex					0						AGAAGGGTTCGCAGCCGCTGG	0.682													3	17					0	0	0	0	A	108868222	A	A	108868222	4	1	65	1	0	0	0	0	0	1	0	0	8061	1095	38	1	404	1	KCNE1L	23	108868222	Nonsense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	1643290	108868222	46402338	608	13439											
ALG13	79868	broad.mit.edu	37	chrX	110924449	110924449	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgaggaacccgcgccatGaagtgcgtgtttgttaccgt	7	11	13	10	4	0	2	0	2	0	0	0	3	0	3	3	1	3	3	3	1	3	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:110924449G>T	uc011msy.1	+	1	37	c.3G>T	c.(1-3)ATG>ATT	p.M1I	ALG13_uc004epi.1_Missense_Mutation_p.M1I|ALG13_uc011msw.1_5'UTR|ALG13_uc011msx.1_5'UTR|ALG13_uc011msz.1_5'UTR|ALG13_uc011mta.1_5'UTR|ALG13_uc011mtb.1_5'UTR			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	1					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						CCCGCGCCATGAAGTGCGTGT	0.602													27	327					9.04072e-19	1.00134e-18	1	0	T	110924449	T	T	110924449	3	4	65	1	0	0	0	0	1	0	0	0	515	1290	45	2	5	2	ALG13	23	110924449	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	2056227	110924449	44346111	609	13440											
DOCK11	139818	broad.mit.edu	37	chrX	117758580	117758580	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atatacagcgattagcaggtCgagataccttgtattcttgt	11	14	9	7	2	1	1	0	0	1	1	2	3	1	1	1	1	4	2	1	1	5	8			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:117758580C>G	uc004eqp.2	+	32	3613	c.3550C>G	c.(3550-3552)CGA>GGA	p.R1184G	DOCK11_uc004eqq.2_Missense_Mutation_p.R963G	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1184					blood coagulation	cytosol	GTP binding			ovary(3)	3						ATTAGCAGGTCGAGATACCTT	0.358													28	365					0	0	0	0	G	117758580	G	G	117758580	3	3	65	1	0	0	0	0	1	0	0	0	4708	876	31	3	3676	3	DOCK11	23	117758580	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	6834131	117758580	37511980	610	13441											
SEPT6	23157	broad.mit.edu	37	chrX	118786948	118786948	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactcttcggatctttagctCttcctgcaggtaggcctcga	6	13	9	13	2	3	0	0	0	3	0	6	2	4	1	2	3	2	3	2	3	2	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:118786948C>G	uc004erv.2	-	4	662	c.397G>C	c.(397-399)GAG>CAG	p.E133Q	SEPT6_uc010nqk.2_RNA|SEPT6_uc004ers.2_Missense_Mutation_p.E133Q|SEPT6_uc004ert.2_Missense_Mutation_p.E133Q|SEPT6_uc004eru.2_Missense_Mutation_p.E133Q|SEPT6_uc004erw.2_Missense_Mutation_p.E75Q|SEPT6_uc011mtv.1_Missense_Mutation_p.E75Q|SEPT6_uc011mtw.1_Missense_Mutation_p.E163Q	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	133					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4						ATCTTTAGCTCTTCCTGCAGG	0.507													14	145					0	0	0	0	G	118786948	G	G	118786948	3	3	65	1	0	0	0	0	1	0	0	0	14133	922	32	2	957	2	SEPT6	23	118786948	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1028368	118786948	36483612	611	13442											
CT47B1	643311	broad.mit.edu	37	chrX	120009419	120009419	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtcggggccggagtcgcCgccctcctggttaccagctc	3	8	14	16	4	0	0	0	0	0	0	4	1	1	1	5	4	2	3	5	4	1	1			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:120009419C>T	uc011muc.1	-	1	361	c.106G>A	c.(106-108)GGC>AGC	p.G36S		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	36											0						CCGGAGTCGCCGCCCTCCTGG	0.731													13	104					0	0	0	0	T	120009419	T	T	120009419	3	4	65	1	0	0	0	0	1	0	0	0	4006	652	23	1	801	1	CT47B1	23	120009419	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	1222471	120009419	35261141	612	13443											
THOC2	57187	broad.mit.edu	37	chrX	122758480	122758480	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtatcgactggcttcatttTcagtacagcttgcaactgtg	8	14	9	10	2	2	0	2	0	0	0	3	1	2	0	0	1	4	5	0	1	3	6			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:122758480T>C	uc004etu.2	-	26	3130	c.3098A>G	c.(3097-3099)GAA>GGA	p.E1033G	THOC2_uc004etw.1_5'Flank	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1033					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						GGCTTCATTTTCAGTACAGCT	0.348													17	350					0	0	0	0	C	122758480	C	C	122758480	3	2	65	1	0	0	0	0	1	0	0	0	15931	1783	62	5	1735	5	THOC2	23	122758480	Missense_Mutation	SNP	T	TCGA-CN-5369-01A-01D-1434-08	2749061	122758480	32512080	613	13444											
ODZ1	10178	broad.mit.edu	37	chrX	124029940	124029941	+	Frame_Shift_Ins	INS	-	T	T																															tttcattccccttatccacaINSttcttagtgcatggtcaggt																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:124029940_124029941insT	uc004euj.2	-	2	431_432	c.367_368insA	c.(367-369)ATGfs	p.M123fs	ODZ1_uc011muj.1_Frame_Shift_Ins_p.M123fs|ODZ1_uc010nqy.2_Frame_Shift_Ins_p.M123fs	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	123	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CCTTATCCACATTCTTAGTGCA	0.495													---	---	---								T	124029941	T	T	124029940	7	5	65	1	0	1	1	0	0	0	0	0	10888	217	8	0	7954	0	ODZ1	23	124029940	Frame_Shift_Ins	INS	-	TCGA-CN-5369-01A-01D-1434-08	1271460	124029940	31240620	614	13445											
ACTRT1	139741	broad.mit.edu	37	chrX	127185700	127185700	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatggggacagtgcaagtGaccccatctccactgtccac	11	7	10	13	0	1	2	0	1	1	1	3	3	2	3	4	2	1	1	4	2	2	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:127185700G>T	uc004eum.2	-	1	683	c.486C>A	c.(484-486)GTC>GTA	p.V162V		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	162						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						CAGTGCAAGTGACCCCATCTC	0.582													14	293					3.27435e-08	3.47347e-08	1	0	T	127185700	T	T	127185700	2	4	65	1	0	0	0	0	0	0	0	1	218	1277	45	2		2	ACTRT1	23	127185700	Silent	SNP	G	TCGA-CN-5369-01A-01D-1434-08	3155760	127185700	28084860	615	13446											
SLC25A14	9016	broad.mit.edu	37	chrX	129483264	129483264	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agacaagcatcatatggcacCattaaaattgggatttacca	16	10	7	8	0	1	1	1	0	0	1	1	2	1	2	2	2	2	2	2	2	5	5			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:129483264C>A	uc004evn.1	+	5	570	c.357C>A	c.(355-357)ACC>ACA	p.T119T	SLC25A14_uc011mut.1_Silent_p.T84T|SLC25A14_uc011muu.1_Silent_p.T119T|SLC25A14_uc010nrg.2_Silent_p.T116T|SLC25A14_uc004evo.1_5'UTR|SLC25A14_uc004evp.1_Silent_p.T119T|SLC25A14_uc004evq.1_Silent_p.T116T|SLC25A14_uc004evr.1_Silent_p.T116T	NM_003951	NP_003942	O95258	UCP5_HUMAN	solute carrier family 25, member 14 isoform	119	Solcar 1.|Helical; Name=2; (Potential).				aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			ovary(1)	1						CATATGGCACCATTAAAATTG	0.343													11	130					0.00829132	0.00834447	1	0	A	129483264	A	A	129483264	2	1	65	1	0	0	0	0	0	0	0	1	14540	581	21	4		4	SLC25A14	23	129483264	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	2297564	129483264	25787296	616	13447											
IGSF1	3547	broad.mit.edu	37	chrX	130409661	130409661	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctactccatggaccggccctCggcaccagagagtaacattc	10	7	9	15	2	0	1	0	0	0	1	3	3	1	2	4	3	2	2	4	3	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:130409661C>T	uc004ewd.2	-	16	3213	c.2975G>A	c.(2974-2976)CGA>CAA	p.R992Q	IGSF1_uc004ewe.3_Missense_Mutation_p.R986Q|IGSF1_uc004ewf.2_Missense_Mutation_p.R972Q	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	992	Extracellular (Potential).|Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GACCGGCCCTCGGCACCAGAG	0.522													17	228					0	0	0	0	T	130409661	T	T	130409661	3	4	65	1	0	0	0	0	1	0	0	0	7635	884	31	1	1055	1	IGSF1	23	130409661	Missense_Mutation	SNP	C	TCGA-CN-5369-01A-01D-1434-08	926397	130409661	24860899	617	13448											
CD40LG	959	broad.mit.edu	37	chrX	135741392	135741392	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	taaagtcccccggtagattcGagagaatcttactcagagct	12	10	9	10	2	2	3	1	0	1	3	4	5	3	3	2	1	2	2	2	1	5	4			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:135741392G>C	uc004faa.2	+	5	676	c.604G>C	c.(604-606)GAG>CAG	p.E202Q	CD40LG_uc010nsd.2_Missense_Mutation_p.E181Q	NM_000074	NP_000065	P29965	CD40L_HUMAN	CD40 ligand	202	Extracellular (Potential).				anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	CGGTAGATTCGAGAGAATCTT	0.483									Immune_Deficiency_with_Hyper-IgM				55	494					0	0	0	0	C	135741392	C	C	135741392	3	2	65	1	0	0	0	0	1	0	0	0	3031	1059	37	3	622	3	CD40LG	23	135741392	Missense_Mutation	SNP	G	TCGA-CN-5369-01A-01D-1434-08	5331731	135741392	19529168	618	13449											
SOX3	6658	broad.mit.edu	37	chrX	139586056	139586056	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcgccgaggcacgcgcgCtgagagtgcgatgcgatggc	7	5	18	11	7	0	1	0	1	0	1	1	5	0	1	1	3	2	2	1	3	0	0			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:139586056C>T	uc004fbd.1	-	1	1170	c.1170G>A	c.(1168-1170)CAG>CAA	p.Q390Q		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	390					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					GGCACGCGCGCTGAGAGTGCG	0.647													4	13					0	0	0	0	T	139586056	T	T	139586056	2	4	65	1	0	0	0	0	0	0	0	1	15015	796	28	4		4	SOX3	23	139586056	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	3844664	139586056	15684504	619	13450											
MAGEA8	4107	broad.mit.edu	37	chrX	149013598	149013598	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcctacatccttgtcacctgCctgggcctctcctatgatgg	5	13	8	15	0	2	1	1	1	1	0	5	1	4	1	6	2	2	0	6	2	2	3			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:149013598C>T	uc004fdw.1	+	3	767	c.552C>T	c.(550-552)TGC>TGT	p.C184C		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	184	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					TTGTCACCTGCCTGGGCCTCT	0.552													6	102					0	0	0	0	T	149013598	T	T	149013598	2	4	65	1	0	0	0	0	0	0	0	1	9222	747	26	4		4	MAGEA8	23	149013598	Silent	SNP	C	TCGA-CN-5369-01A-01D-1434-08	9427542	149013598	6256962	620	13451											
SRPK3	26576	broad.mit.edu	37	chrX	153049647	153049647	+	Frame_Shift_Del	DEL	G	-	-																															cgtccaatcagcgagagaccGggggcctcctgtcgcctagc																										TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:153049647delG	uc004fil.2	+	10	1158	c.1126delG	c.(1126-1128)GGGfs	p.G376fs	SRPK3_uc004fik.2_Frame_Shift_Del_p.G442fs|SRPK3_uc010nul.2_Frame_Shift_Del_p.G300fs|SRPK3_uc004fin.2_Frame_Shift_Del_p.G375fs|SRPK3_uc004fim.2_Frame_Shift_Del_p.G342fs	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	376	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GCGAGAGACCGGGGGCCTCCT	0.642													---	---	---								-	153049647	-	-	153049647	7	5	65	1	0	1	0	1	0	0	0	0	15227	1116	39	0	1164	0	SRPK3	23	153049647	Frame_Shift_Del	DEL	G	TCGA-CN-5369-01A-01D-1434-08	4036049	153049647	2220913	621	13452											
FLNA	2316	broad.mit.edu	37	chrX	153577807	153577807	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccaggcccttggccaccAccttgctggcgtcagcaggc	5	6	12	18	1	1	0	1	0	0	0	1	0	1	0	6	4	2	2	6	4	0	2			TCGA-CN-5369-01A-01D-1434-08	TCGA-CN-5369-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c8e6937-9fd7-41cc-ac74-d8b75235d4b3	ff349f37-b5ea-4475-bcd8-02d18f80c40e	g.chrX:153577807A>G	uc004fkk.2	-	47	7928	c.7679T>C	c.(7678-7680)GTG>GCG	p.V2560A	FLNA_uc004fki.2_Missense_Mutation_p.V600A|FLNA_uc011mzn.1_Missense_Mutation_p.V693A|FLNA_uc010nuu.1_Missense_Mutation_p.V2552A	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2560	Self-association site, tail.|Filamin 24.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTTGGCCACCACCTTGCTGGC	0.652													17	176					0	0	0	0	G	153577807	G	G	153577807	3	3	65	1	0	0	0	0	1	0	0	0	5965	159	6	5	272	5	FLNA	23	153577807	Missense_Mutation	SNP	A	TCGA-CN-5369-01A-01D-1434-08	528160	153577807	1692753	622	13453											
PLEKHN1	84069	broad.mit.edu	37	chr1	909316	909316	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccctcgctcctgctcctccgGccccgctggcccctacttgc	1	9	8	23	3	0	0	0	0	0	0	4	0	3	0	8	2	3	3	8	2	1	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:909316G>T	uc001ace.2	+	13	1729	c.1694G>T	c.(1693-1695)GGC>GTC	p.G565V	PLEKHN1_uc001acd.2_Missense_Mutation_p.G513V|PLEKHN1_uc001acf.2_Missense_Mutation_p.G478V	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	565											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		TGCTCCTCCGGCCCCGCTGGC	0.692													6	28					3.59834e-05	4.32883e-05	1	0	T	909316	T	T	909316	3	4	66	1	0	0	0	0	1	0	0	0	12138	1203	42	4	1628	4	PLEKHN1	1	909316	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08		909316	248341305	1	13454											
CCNL2	81669	broad.mit.edu	37	chr1	1325617	1325617	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctaacagactcacccagcttGggggcaggagagaaccccga	12	4	12	13	1	1	2	1	0	0	2	1	5	1	3	3	3	3	2	3	3	2	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:1325617G>A	uc001afi.2	-	8	1031	c.999C>T	c.(997-999)CCC>CCT	p.P333P	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Silent_p.P111P|CCNL2_uc001afg.1_Silent_p.P111P|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	333					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CACCCAGCTTGGGGGCAGGAG	0.597													24	140					0	0	0	0	A	1325617	A	A	1325617	2	1	66	1	0	0	0	0	0	0	0	1	2947	1335	47	4		4	CCNL2	1	1325617	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08	416301	1325617	247925004	2	13455											
CLCNKA	1187	broad.mit.edu	37	chr1	16359665	16359665	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cctaacaatcccccatccagGcacaaaacctctttaagctg	13	8	4	16	0	1	0	0	0	1	0	3	0	3	0	5	1	3	2	5	1	5	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:16359665G>A	uc001axu.2	+	19	2010	c.1930G>A	c.(1930-1932)GCA>ACA	p.A644T	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.A643T|CLCNKA_uc010obw.1_Missense_Mutation_p.A601T|CLCNKB_uc001axw.3_Intron	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	644	CBS 2.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CCCCATCCAGGCACAAAACCT	0.627											OREG0013132	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	205					0	0	0	0	A	16359665	A	A	16359665	3	1	66	1	0	0	0	0	1	0	0	0	3484	1217	42	4	2000	4	CLCNKA	1	16359665	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	15034048	16359665	232890956	3	13456											
GPSM2	29899	broad.mit.edu	37	chr1	109446790	109446790	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacagcacgacttaatctctCagaccttcaaatggttcttg	12	12	6	11	1	4	1	2	0	2	1	5	2	4	1	1	1	2	2	1	1	3	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:109446790C>G	uc010ovc.1	+	10	1602	c.1106C>G	c.(1105-1107)TCA>TGA	p.S369*	AKNAD1_uc010ovb.1_Intron|GPSM2_uc010ovd.1_Nonsense_Mutation_p.S369*|GPSM2_uc010ove.1_Nonsense_Mutation_p.S369*	NM_013296	NP_037428	P81274	GPSM2_HUMAN	LGN protein	369					G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		CTTAATCTCTCAGACCTTCAA	0.348													7	40					0	0	0	0	G	109446790	G	G	109446790	4	3	66	1	0	0	0	0	0	1	0	0	6774	838	29	2	1140	2	GPSM2	1	109446790	Nonsense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	93087125	109446790	139803831	4	13457											
PDE4DIP	9659	broad.mit.edu	37	chr1	144882464	144882464	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttggtgggcatccactgtGaaggtagccccaaggtcaag	10	8	13	10	0	1	1	1	1	0	0	2	1	2	1	3	4	1	2	3	4	4	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:144882464G>A	uc001elw.3	-	24	3846	c.3555C>T	c.(3553-3555)TTC>TTT	p.F1185F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Silent_p.F192F	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1185					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CATCCACTGTGAAGGTAGCCC	0.502			T	PDGFRB	MPD								7	107					0	0	0	0	A	144882464	A	A	144882464	2	1	66	1	0	0	0	0	0	0	0	1	11697	1281	45	2		2	PDE4DIP	1	144882464	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08	35435674	144882464	104368157	5	13458											
GATAD2B	57459	broad.mit.edu	37	chr1	153790617	153790618	+	Frame_Shift_Ins	INS	-	A	A																															tgggcaggagatggctgaacINSaatagatgctgcattctgta																										TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:153790617_153790618insA	uc001fdb.3	-	5	871_872	c.627_628insT	c.(625-630)ATTGTTfs	p.I209fs		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	209_210						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GATGGCTGAACAATAGATGCTG	0.475													---	---	---								A	153790618	A	A	153790617	7	5	66	1	0	1	1	0	0	0	0	0	6296	478	17	0	1181	0	GATAD2B	1	153790617	Frame_Shift_Ins	INS	-	TCGA-CN-5370-01A-01D-2012-08	8908153	153790617	95460004	6	13459											
ATP1A2	477	broad.mit.edu	37	chr1	160109515	160109515	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcatgggtgtagccctcCgcatgtacccgctcaagtga	8	8	12	13	2	1	1	1	1	0	0	2	1	2	1	3	2	2	5	3	2	3	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:160109515C>T	uc001fvc.2	+	21	3058	c.2926C>T	c.(2926-2928)CGC>TGC	p.R976C	ATP1A2_uc001fvd.2_Missense_Mutation_p.R695C	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	976	Extracellular (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGTAGCCCTCCGCATGTACCC	0.557													18	47					0	0	0	0	T	160109515	T	T	160109515	3	4	66	1	0	0	0	0	1	0	0	0	1131	652	23	1	3008	1	ATP1A2	1	160109515	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	6318898	160109515	89141106	7	13460											
IVNS1ABP	10625	broad.mit.edu	37	chr1	185274695	185274696	+	Frame_Shift_Ins	INS	-	CT	CT																															actgaatgtggtcatcatcaINSctgccaaacacctcagcctg																										TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:185274695_185274696insCT	uc001grl.2	-	8	1360_1361	c.737_738insAG	c.(736-738)AGTfs	p.S246fs	IVNS1ABP_uc001grj.2_5'UTR|IVNS1ABP_uc009wyj.2_Frame_Shift_Ins_p.S28fs|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	246	Sufficient for AHR interaction and signaling.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						GGTCATCATCACTGCCAAACAC	0.416													---	---	---								CT	185274696	CT	CT	185274695	7	5	66	1	0	1	1	0	0	0	0	0	7969	156	6	0	1222	0	IVNS1ABP	1	185274695	Frame_Shift_Ins	INS	-	TCGA-CN-5370-01A-01D-2012-08	25165180	185274695	63975926	8	13461											
SOX13	9580	broad.mit.edu	37	chr1	204082212	204082212	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acccagcccgggcctcccagGatagtgctgacccccaagct	8	5	10	18	1	0	1	0	1	0	0	1	2	1	2	6	2	3	2	6	2	2	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:204082212G>A	uc001ham.2	+	2	764	c.169G>A	c.(169-171)GAT>AAT	p.D57N	SOX13_uc001hal.2_Missense_Mutation_p.D57N|SOX13_uc010pqp.1_Missense_Mutation_p.D57N|SOX13_uc010pqq.1_5'Flank	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	57					anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			GGCCTCCCAGGATAGTGCTGA	0.652													5	18					0	0	0	0	A	204082212	A	A	204082212	3	1	66	1	0	0	0	0	1	0	0	0	15008	1174	41	2	171	2	SOX13	1	204082212	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	18807517	204082212	45168409	9	13462											
RBM34	23029	broad.mit.edu	37	chr1	235324324	235324324	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgaaataagctactggcgaCctgtccaagcctgtagtctt	10	10	10	11	2	1	0	0	0	1	0	2	2	2	0	3	1	3	2	3	1	5	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:235324324C>T	uc001hwn.2	-	2	142	c.112G>A	c.(112-114)GTC>ATC	p.V38I	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Missense_Mutation_p.V38I	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	38						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			CTACTGGCGACCTGTCCAAGC	0.597													4	64					0	0	0	0	T	235324324	T	T	235324324	3	4	66	1	0	0	0	0	1	0	0	0	13196	507	18	4	1241	4	RBM34	1	235324324	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	31242112	235324324	13926297	10	13463											
CEP170	9859	broad.mit.edu	37	chr1	243362360	243362360	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagtgactgagatttttttAcctgatgttccagcttcatg	9	16	8	8	0	1	3	1	3	0	1	2	4	2	3	2	0	2	2	2	0	1	6			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:243362360A>G	uc001hzs.2	-	7	1039	c.631_splice	c.e7+1	p.G211_splice	CEP170_uc001hzt.2_Splice_Site_p.G211_splice|CEP170_uc001hzu.2_Splice_Site_p.G211_splice	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha							centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			AGATTTTTTTACCTGATGTTC	0.403													5	36					0	0	0	0	G	243362360	G	G	243362360	5	3	66	1	0	0	0	0	0	0	1	0	3265	405	14	5	4207	5	CEP170	1	243362360	Splice_Site	SNP	A	TCGA-CN-5370-01A-01D-2012-08	8038036	243362360	5888261	11	13464											
OR2T12	127064	broad.mit.edu	37	chr1	248458187	248458187	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtggcaaaggccttcttgcGggcttctgtagagcgcatga	7	10	15	9	2	2	2	0	1	2	1	2	2	2	2	1	4	2	4	1	4	2	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr1:248458187G>A	uc010pzj.1	-	1	694	c.694C>T	c.(694-696)CGC>TGC	p.R232C		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GCCTTCTTGCGGGCTTCTGTA	0.522													24	86					0	0	0	0	A	248458187	A	A	248458187	3	1	66	1	0	0	0	0	1	0	0	0	11073	1116	39	1	271	1	OR2T12	1	248458187	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	5095827	248458187	792434	12	13465											
NBAS	51594	broad.mit.edu	37	chr2	15417095	15417095	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaataatactgcagcctttCgtgatcaaagccaccaatag	15	9	7	10	1	1	1	1	1	0	0	2	2	1	1	3	0	4	1	3	0	6	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr2:15417095C>T	uc002rcc.1	-	43	5295	c.5269G>A	c.(5269-5271)GAA>AAA	p.E1757K	NBAS_uc010exl.1_Missense_Mutation_p.E829K|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1757										ovary(2)|liver(1)|skin(1)	4						TGCAGCCTTTCGTGATCAAAG	0.438													12	41					0	0	0	0	T	15417095	T	T	15417095	3	4	66	1	0	0	0	0	1	0	0	0	10239	893	31	1	1886	1	NBAS	2	15417095	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08		15417095	227782278	13	13466											
ALK	238	broad.mit.edu	37	chr2	29462560	29462560	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acttacactggggcaggcgtCctctccctgctgcccaacca	7	8	9	17	1	1	0	0	0	1	0	3	0	2	0	4	3	4	2	4	3	2	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr2:29462560C>T	uc002rmy.2	-	13	3248	c.2341G>A	c.(2341-2343)GAC>AAC	p.D781N		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	781	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GGGCAGGCGTCCTCTCCCTGC	0.602			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				14	52					0	0	0	0	T	29462560	T	T	29462560	3	4	66	1	0	0	0	0	1	0	0	0	525	855	30	2	2589	2	ALK	2	29462560	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	14045465	29462560	213736813	14	13467											
NLRC4	58484	broad.mit.edu	37	chr2	32477515	32477515	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	attcaagtcctgaaatagagGatagttccactccttaaggg	13	11	9	8	0	1	2	1	1	0	1	4	3	4	3	3	2	0	1	3	2	5	5			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr2:32477515G>A	uc002roi.2	-	3	481	c.235C>T	c.(235-237)CCT>TCT	p.P79S	NLRC4_uc002roj.1_Missense_Mutation_p.P79S|NLRC4_uc010ezt.1_Missense_Mutation_p.P79S	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	79	CARD.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TGAAATAGAGGATAGTTCCAC	0.413													9	62					0	0	0	0	A	32477515	A	A	32477515	3	1	66	1	0	0	0	0	1	0	0	0	10523	1174	41	2	2867	2	NLRC4	2	32477515	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	3014955	32477515	210721858	15	13468											
PNPT1	87178	broad.mit.edu	37	chr2	55895069	55895069	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaaggattctattatttcaTatggatcggcttctggaaat	11	16	9	5	1	3	1	1	1	2	0	4	4	3	4	0	4	0	1	0	4	5	6			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr2:55895069T>G	uc002rzf.2	-	12	1054	c.1001A>C	c.(1000-1002)TAT>TCT	p.Y334S	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	334					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TATTATTTCATATGGATCGGC	0.279													13	34					0	0	0	0	G	55895069	G	G	55895069	3	3	66	1	0	0	0	0	1	0	0	0	12228	1406	49	5	1418	5	PNPT1	2	55895069	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	23417554	55895069	187304304	16	13469											
VWA3B	200403	broad.mit.edu	37	chr2	98914471	98914471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcacgcctgtggggggcGccatgccctgcccgctgctc	3	8	13	17	3	2	0	2	0	0	0	3	0	2	0	4	3	3	2	4	3	0	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr2:98914471G>A	uc002syo.2	+	24	3523	c.3259G>A	c.(3259-3261)GCC>ACC	p.A1087T	VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.A744T|VWA3B_uc002syp.1_Missense_Mutation_p.A479T|VWA3B_uc002syq.1_Missense_Mutation_p.A363T|VWA3B_uc002syr.1_Missense_Mutation_p.A404T|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1087										ovary(3)|large_intestine(2)|skin(1)	6						TGTGGGGGGCGCCATGCCCTG	0.587													21	89					0	0	0	0	A	98914471	A	A	98914471	3	1	66	1	0	0	0	0	1	0	0	0	17309	1087	38	1	3349	1	VWA3B	2	98914471	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	43019402	98914471	144284902	17	13470											
TTN	7273	broad.mit.edu	37	chr2	179474486	179474486	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcggcgttctctgctcgcaCacggaattggtactctttcc	5	12	10	14	5	2	0	0	0	2	0	5	1	3	1	1	3	2	4	1	3	2	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr2:179474486C>T	uc010zfg.1	-	221	44184	c.43960G>A	c.(43960-43962)GTG>ATG	p.V14654M	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V8349M|TTN_uc010zfi.1_Missense_Mutation_p.V8282M|TTN_uc010zfj.1_Missense_Mutation_p.V8157M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15581							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGCTCGCACACGGAATTGG	0.483													15	411					0	0	0	0	T	179474486	T	T	179474486	3	4	66	1	0	0	0	0	1	0	0	0	16803	478	17	4	56393	4	TTN	2	179474486	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	80560015	179474486	63724887	18	13471											
HRH1	3269	broad.mit.edu	37	chr3	11300945	11300945	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcctctcggtggcggacttGatcgtgggtgccgtcgtcat	4	11	15	11	5	2	1	1	1	1	0	5	2	2	2	2	4	2	0	2	4	0	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr3:11300945G>A	uc010hdr.2	+	2	564	c.222G>A	c.(220-222)TTG>TTA	p.L74L	HRH1_uc010hds.2_Silent_p.L74L|HRH1_uc010hdt.2_Silent_p.L74L|HRH1_uc003bwb.3_Silent_p.L74L	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	74	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	TGGCGGACTTGATCGTGGGTG	0.577													13	97					0	0	0	0	A	11300945	A	A	11300945	2	1	66	1	0	0	0	0	0	0	0	1	7394	1281	45	2		2	HRH1	3	11300945	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08		11300945	186721485	19	13472											
GALNTL2	117248	broad.mit.edu	37	chr3	16216900	16216900	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgaagagtacagccctcTggagggcctgccacccttta	8	8	13	12	0	1	2	0	1	1	1	1	3	1	3	4	3	3	1	4	3	3	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr3:16216900T>C	uc003car.3	+	1	717	c.242T>C	c.(241-243)CTG>CCG	p.L81P	GALNTL2_uc003caq.3_Intron	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	81	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						TACAGCCCTCTGGAGGGCCTG	0.617													4	64					0	0	0	0	C	16216900	C	C	16216900	3	2	66	1	0	0	0	0	1	0	0	0	6257	1580	55	5	244	5	GALNTL2	3	16216900	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	4915955	16216900	181805530	20	13473											
CD200R1L	344807	broad.mit.edu	37	chr3	112538730	112538730	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggacaacgctggagatcctGaggttctgagacctttaaat	12	10	11	8	1	1	3	0	2	1	2	2	6	2	4	2	3	1	2	2	3	3	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr3:112538730G>A	uc003dzi.1	-	5	918	c.692C>T	c.(691-693)TCA>TTA	p.S231L	CD200R1L_uc011bhw.1_Missense_Mutation_p.S210L|CD200R1L_uc010hqf.1_Missense_Mutation_p.S210L	NM_001008784	NP_001008784	Q6Q8B3	MO2R2_HUMAN	CD200 cell surface glycoprotein receptor 2	231	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)	1						TGGAGATCCTGAGGTTCTGAG	0.353													8	58					0	0	0	0	A	112538730	A	A	112538730	3	1	66	1	0	0	0	0	1	0	0	0	2997	1294	45	2	131	2	CD200R1L	3	112538730	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	96321830	112538730	85483700	21	13474											
ZXDC	79364	broad.mit.edu	37	chr3	126180734	126180734	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgaagctgccctgctgcaGaaccgtggctgctgtcccga	7	8	12	14	2	0	2	0	1	0	1	1	3	1	2	3	1	6	5	3	1	2	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr3:126180734G>A	uc003eiv.2	-	6	1825	c.1771C>T	c.(1771-1773)CTG>TTG	p.L591L	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Silent_p.L591L	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	591	Required for transcriptional activation.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		CCCTGCTGCAGAACCGTGGCT	0.602													23	90					0	0	0	0	A	126180734	A	A	126180734	2	1	66	1	0	0	0	0	0	0	0	1	18319	933	33	2		2	ZXDC	3	126180734	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08	13642004	126180734	71841696	22	13475											
SELT	51714	broad.mit.edu	37	chr3	150321023	150321032	+	5'Flank	DEL	GGCGCATTAC	-	-																															cgcgggcgccgggccgcgcaGgcgcattactgctcccctcc																										TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr3:150321023_150321032delGGCGCATTAC	uc011bnx.1	+						SERP1_uc003exz.2_5'Flank|uc003eye.1_5'Flank	NM_016275	NP_057359	P62341	SELT_HUMAN	selenoprotein T precursor						cell redox homeostasis|selenocysteine incorporation		selenium binding				0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GGGCCGCGCAGGCGCATTACTGCTCCCCTC	0.662													---	---	---								-	150321032	-	-	150321023	6	5	66	0	1	1	0	1	0	0	0	0	14087	1015	35	0		0	SELT	3	150321023	5'Flank	DEL	GGCGCATTAC	TCGA-CN-5370-01A-01D-2012-08	24140289	150321023	47701407	23	13476											
ATP13A3	79572	broad.mit.edu	37	chr3	194126832	194126832	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaagcagcattttccccacCgatccactgactcctaagaa	12	9	6	14	1	0	2	0	1	0	1	3	3	3	2	5	0	2	3	5	0	3	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr3:194126832C>T	uc003fty.3	-	32	3899	c.3497G>A	c.(3496-3498)CGG>CAG	p.R1166Q	ATP13A3_uc003ftx.3_Missense_Mutation_p.R75Q	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	1166					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TTTTCCCCACCGATCCACTGA	0.433													7	61					0	0	0	0	T	194126832	T	T	194126832	3	4	66	1	0	0	0	0	1	0	0	0	1127	652	23	1	187	1	ATP13A3	3	194126832	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	43805809	194126832	3895598	24	13477											
GK2	2712	broad.mit.edu	37	chr4	80328273	80328273	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaccctgaaaaggctgggAcaaagtaacagccataagaa	19	5	9	8	0	0	2	0	1	0	1	0	3	0	3	2	2	3	2	2	2	7	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr4:80328273A>G	uc003hlu.2	-	1	1100	c.1082T>C	c.(1081-1083)GTC>GCC	p.V361A		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	361					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						AAAGGCTGGGACAAAGTAACA	0.413													17	89					0	0	0	0	G	80328273	G	G	80328273	3	3	66	1	0	0	0	0	1	0	0	0	6458	275	10	5	583	5	GK2	4	80328273	Missense_Mutation	SNP	A	TCGA-CN-5370-01A-01D-2012-08		80328273	110826003	25	13478											
HADH	3033	broad.mit.edu	37	chr4	108935703	108935703	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgtggagaatctgaaggtGaaaaacgagctcttcaaaag	16	8	11	6	2	3	3	1	2	2	1	4	5	3	3	0	2	2	1	0	2	6	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr4:108935703G>A	uc003hyq.2	+	3	527	c.378G>A	c.(376-378)GTG>GTA	p.V126V	HADH_uc010ilx.2_Silent_p.V126V|HADH_uc010ily.2_Intron|HADH_uc003hyr.2_Silent_p.V130V	NM_005327	NP_005318	Q16836	HCDH_HUMAN	L-3-hydroxyacyl-Coenzyme A dehydrogenase	126					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)	ATCTGAAGGTGAAAAACGAGC	0.438													19	87					0	0	0	0	A	108935703	A	A	108935703	2	1	66	1	0	0	0	0	0	0	0	1	6981	1277	45	2		2	HADH	4	108935703	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08	28607430	108935703	82218573	26	13479											
C4orf49	84709	broad.mit.edu	37	chr4	140196504	140196504	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataaatcatatttgatccaGatgatccagggaatctgtta	15	13	7	6	0	2	3	1	2	1	1	4	4	4	4	2	1	0	1	2	1	6	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr4:140196504G>C	uc003ihr.1	-	2	305	c.125C>G	c.(124-126)TCT>TGT	p.S42C		NM_032623	NP_116012	Q8TDB4	CD049_HUMAN	ovary-specific acidic protein	42	Helical; (Potential).					integral to membrane				central_nervous_system(1)|skin(1)	2						ATTTGATCCAGATGATCCAGG	0.368													3	53					0	0	0	0	C	140196504	C	C	140196504	3	2	66	1	0	0	0	0	1	0	0	0	2285	942	33	2	609	2	C4orf49	4	140196504	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	31260801	140196504	50957772	27	13480											
FHDC1	85462	broad.mit.edu	37	chr4	153897721	153897721	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggcgagccagcagtgcccGggcccccaagaagcgcccag	9	1	15	16	3	0	1	0	0	0	1	0	3	0	1	5	2	4	1	5	2	2	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr4:153897721G>A	uc003inf.2	+	11	3353	c.3278G>A	c.(3277-3279)CGG>CAG	p.R1093Q		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	1093					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					AGCAGTGCCCGGGCCCCCAAG	0.682													5	29					0	0	0	0	A	153897721	A	A	153897721	3	1	66	1	0	0	0	0	1	0	0	0	5908	1116	39	1	3320	1	FHDC1	4	153897721	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	13701217	153897721	37256555	28	13481											
FAT1	2195	broad.mit.edu	37	chr4	187629576	187629580	+	Frame_Shift_Del	DEL	TTGTA	-	-																															cgttctcatcaaaagcagctTtgtacgctgtctgggtaaat																										TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr4:187629576_187629580delTTGTA	uc003izf.2	-	2	1590_1594	c.1402_1406delTACAA	c.(1402-1407)TACAAAfs	p.Y468fs	FAT1_uc010iso.1_Frame_Shift_Del_p.Y468fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	468_469	Extracellular (Potential).|Cadherin 4.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AAAAGCAGCTTTGTACGCTGTCTGG	0.473										HNSCC(5;0.00058)			---	---	---								-	187629580	-	-	187629576	7	5	66	1	0	1	0	1	0	0	0	0	5721	1841	64	0	12464	0	FAT1	4	187629576	Frame_Shift_Del	DEL	TTGTA	TCGA-CN-5370-01A-01D-2012-08	33731855	187629576	3524700	29	13482											
CCDC125	202243	broad.mit.edu	37	chr5	68616363	68616363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgatgatcttgccaccttgCtcatgagccaaatgccgtct	8	13	8	12	1	3	3	1	3	2	0	3	3	3	3	4	0	4	1	4	0	1	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr5:68616363C>T	uc003jvv.1	-	1	48	c.5G>A	c.(4-6)AGC>AAC	p.S2N	CCDC125_uc003jvx.1_Missense_Mutation_p.S2N|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_5'UTR|CCDC125_uc003jvz.1_Missense_Mutation_p.S2N	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	2						cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		TGCCACCTTGCTCATGAGCCA	0.393													13	60					0	0	0	0	T	68616363	T	T	68616363	3	4	66	1	0	0	0	0	1	0	0	0	2773	797	28	4	1574	4	CCDC125	5	68616363	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08		68616363	112298897	30	13483											
PCDHGC4	56098	broad.mit.edu	37	chr5	140866446	140866446	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccagctgtgctccgtcctcGggcccggcctggttccttat	2	12	11	16	3	0	0	0	0	0	0	5	0	4	0	6	3	2	3	6	3	1	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr5:140866446G>A	uc003lky.1	+	1	1706	c.1706G>A	c.(1705-1707)CGG>CAG	p.R569Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Missense_Mutation_p.R569Q|PCDHGC5_uc011dbc.1_5'Flank|PCDHGC5_uc003lla.1_5'Flank	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	569	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCGTCCTCGGGCCCGGCCT	0.572													30	101					0	0	0	0	A	140866446	A	A	140866446	3	1	66	1	0	0	0	0	1	0	0	0	11624	1116	39	1	1708	1	PCDHGC4	5	140866446	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	72250083	140866446	40048814	31	13484											
PDGFRB	5159	broad.mit.edu	37	chr5	149516594	149516594	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgagggccagagctggcatcGcacccggaagccgcatggtg	8	5	16	12	3	0	2	0	1	0	1	1	3	0	3	3	4	2	4	3	4	1	0	rs150173975	byFrequency	TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr5:149516594G>A	uc003lro.2	-	2	486	c.17C>T	c.(16-18)GCG>GTG	p.A6V	PDGFRB_uc010jhd.2_5'UTR|PDGFRB_uc011dcg.1_Missense_Mutation_p.A6V	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	6					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGCTGGCATCGCACCCGGAAG	0.642			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								11	45					0	0	0	0	A	149516594	A	A	149516594	3	1	66	1	0	0	0	0	1	0	0	0	11716	1087	38	1	3391	1	PDGFRB	5	149516594	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	8650148	149516594	31398666	32	13485											
C6orf106	64771	broad.mit.edu	37	chr6	34614452	34614452	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctctgctggggctgcacAtctggacgctgacatctgca	6	10	12	13	1	3	1	0	1	3	0	3	2	3	2	0	3	4	6	0	3	0	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr6:34614452A>C	uc003ojr.2	-	3	682	c.437T>G	c.(436-438)ATG>AGG	p.M146R	C6orf106_uc003ojs.2_Intron	NM_024294	NP_077270	Q9H6K1	CF106_HUMAN	chromosome 6 open reading frame 106 isoform a	146										skin(2)|ovary(1)	3						GGGGCTGCACATCTGGACGCT	0.522													18	234					0	0	0	0	C	34614452	C	C	34614452	3	2	66	1	0	0	0	0	1	0	0	0	2329	217	8	5	471	5	C6orf106	6	34614452	Missense_Mutation	SNP	A	TCGA-CN-5370-01A-01D-2012-08		34614452	136500615	33	13486											
FGD2	221472	broad.mit.edu	37	chr6	36989314	36989314	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caagcagccattgaccaaatCgagaagcggaatgaaacctt	16	6	9	10	2	0	3	0	2	0	1	1	5	0	4	3	1	4	1	3	1	5	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr6:36989314C>T	uc010jwp.1	+	12	1431	c.1260C>T	c.(1258-1260)ATC>ATT	p.I420I	FGD2_uc003ong.2_Silent_p.I142I|FGD2_uc011dtv.1_Silent_p.I48I|FGD2_uc003onj.1_5'Flank	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	420					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						TTGACCAAATCGAGAAGCGGA	0.597											OREG0017395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	26					0	0	0	0	T	36989314	T	T	36989314	2	4	66	1	0	0	0	0	0	0	0	1	5865	874	31	1		1	FGD2	6	36989314	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08	2374862	36989314	134125753	34	13487											
LRFN2	57497	broad.mit.edu	37	chr6	40360623	40360623	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacaccaggttgttgaccaCgaaggccttgttggaggctg	8	10	14	9	1	0	2	0	2	0	0	0	4	0	3	3	4	0	4	3	4	1	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr6:40360623C>T	uc003oph.1	-	3	1894	c.1429G>A	c.(1429-1431)GTG>ATG	p.V477M		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	477	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TTGTTGACCACGAAGGCCTTG	0.557													3	34					0	0	0	0	T	40360623	T	T	40360623	3	4	66	1	0	0	0	0	1	0	0	0	8988	536	19	1	944	1	LRFN2	6	40360623	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	3371309	40360623	130754444	35	13488											
DOPEY1	23033	broad.mit.edu	37	chr6	83832654	83832656	+	In_Frame_Del	DEL	TTA	-	-																															ctctttaattccttcgaaccTtattatatgtgggattatgt																										TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr6:83832654_83832656delTTA	uc003pjs.1	+	12	1553_1555	c.1293_1295delTTA	c.(1291-1296)CCTTAT>CCT	p.Y433del	DOPEY1_uc011dyy.1_In_Frame_Del_p.Y424del|DOPEY1_uc010kbl.1_In_Frame_Del_p.Y424del	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	433					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CCTTCGAACCTTATTATATGTGG	0.315													---	---	---								-	83832656	-	-	83832654	7	5	66	1	0	1	0	1	0	0	0	0	4729	1596	56	0	1331	0	DOPEY1	6	83832654	In_Frame_Del	DEL	TTA	TCGA-CN-5370-01A-01D-2012-08	43472031	83832654	87282413	36	13489											
SYNE1	23345	broad.mit.edu	37	chr6	152832220	152832220	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcagctatatcggtggagtTaatgttgactaatttaatct	12	16	8	5	1	2	1	1	1	1	0	3	2	2	2	0	2	1	3	0	2	5	7			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr6:152832220T>A	uc010kiw.2	-	7	930	c.328A>T	c.(328-330)AAC>TAC	p.N110Y	SYNE1_uc003qot.3_Missense_Mutation_p.N117Y|SYNE1_uc003qou.3_Missense_Mutation_p.N110Y|SYNE1_uc010kjb.1_Missense_Mutation_p.N110Y|SYNE1_uc003qpa.1_Missense_Mutation_p.N110Y	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	110	Actin-binding.|Cytoplasmic (Potential).|CH 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCGGTGGAGTTAATGTTGACT	0.328										HNSCC(10;0.0054)			32	109					0	0	0	0	A	152832220	A	A	152832220	3	1	66	1	0	0	0	0	1	0	0	0	15511	1754	61	5	26698	5	SYNE1	6	152832220	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	68999566	152832220	18282847	37	13490											
DNAH11	8701	broad.mit.edu	37	chr7	21609805	21609806	+	Frame_Shift_Ins	INS	-	A	A																															aactcctttttcaactatagINSaaaaaaattggcaagctact																										TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr7:21609805_21609806insA	uc003svc.2	+	7	1344_1345	c.1313_1314insA	c.(1312-1314)AGAfs	p.R438fs		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	438	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TTCAACTATAGAAAAAAATTGG	0.391									Kartagener_syndrome				---	---	---								A	21609806	A	A	21609805	7	5	66	1	0	1	1	0	0	0	0	0	4621	942	33	0	1339	0	DNAH11	7	21609805	Frame_Shift_Ins	INS	-	TCGA-CN-5370-01A-01D-2012-08		21609805	137528858	38	13491											
RAPGEF5	9771	broad.mit.edu	37	chr7	22190076	22190076	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tatattcgaccagatgcctcGagggatttggagatgactaa	12	11	11	7	2	0	3	0	1	0	2	2	7	0	4	2	2	1	0	2	2	3	5			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr7:22190076G>C	uc003svg.2	-	18	1687	c.1374C>G	c.(1372-1374)CTC>CTG	p.L458L	RAPGEF5_uc011jyl.1_Silent_p.L139L	NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	308					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						CAGATGCCTCGAGGGATTTGG	0.343													10	121					0	0	0	0	C	22190076	C	C	22190076	2	2	66	1	0	0	0	0	0	0	0	1	13112	1045	37	3		3	RAPGEF5	7	22190076	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08	580271	22190076	136948587	39	13492											
OGDH	4967	broad.mit.edu	37	chr7	44684960	44684960	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttttcgcaacacgaatgccgGagccccaccgggcactgcct	8	7	10	16	4	0	0	0	0	0	0	1	2	0	1	5	2	4	2	5	2	2	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr7:44684960G>C	uc003tln.2	+	3	366	c.257G>C	c.(256-258)GGA>GCA	p.G86A	OGDH_uc003tlm.2_Missense_Mutation_p.G86A|OGDH_uc011kbx.1_Missense_Mutation_p.G86A|OGDH_uc011kby.1_Intron|OGDH_uc003tlp.2_Missense_Mutation_p.G86A|OGDH_uc011kbz.1_5'UTR|OGDH_uc003tlo.1_5'UTR	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	86					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	ACGAATGCCGGAGCCCCACCG	0.582													21	162					0	0	0	0	C	44684960	C	C	44684960	3	2	66	1	0	0	0	0	1	0	0	0	10893	1174	41	2	263	2	OGDH	7	44684960	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	22494884	44684960	114453703	40	13493											
MYO1G	64005	broad.mit.edu	37	chr7	45010561	45010561	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggtcccggggtgtggccGtcagctcagccacatggtcc	5	7	15	14	3	2	0	2	0	0	0	4	1	4	0	4	5	2	1	4	5	0	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr7:45010561G>A	uc003tmh.2	-	8	1088	c.944C>T	c.(943-945)ACG>ATG	p.T315M	MYO1G_uc003tmf.2_5'Flank|MYO1G_uc003tmg.2_Missense_Mutation_p.T77M|MYO1G_uc010kym.2_Missense_Mutation_p.T200M|MYO1G_uc003tmi.1_Missense_Mutation_p.T227M|MYO1G_uc003tmj.2_Missense_Mutation_p.T77M	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	315	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						GGGTGTGGCCGTCAGCTCAGC	0.657													9	36					0	0	0	0	A	45010561	A	A	45010561	3	1	66	1	0	0	0	0	1	0	0	0	10127	1145	40	1	2172	1	MYO1G	7	45010561	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	325601	45010561	114128102	41	13494											
ELN	2006	broad.mit.edu	37	chr7	73474233	73474250	+	In_Frame_Del	DEL	GGCGTGGCTCCTGGAGTT	-	-																															cagggttagttcctggtgtcGgcgtggctcctggagttggc																										TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr7:73474233_73474250delGGCGTGGCTCCTGGAGTT	uc003tzw.2	+	23	1541_1558	c.1450_1467delGGCGTGGCTCCTGGAGTT	c.(1450-1467)GGCGTGGCTCCTGGAGTTdel	p.GVAPGV496del	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_In_Frame_Del_p.GVAPGV490del|ELN_uc003tzz.2_In_Frame_Del_p.GVAPGV409del|ELN_uc003tzo.2_In_Frame_Del_p.GVAPGV457del|ELN_uc003tzp.2_In_Frame_Del_p.GVAPGV401del|ELN_uc003tzq.2_In_Frame_Del_p.GVAPGV354del|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_In_Frame_Del_p.GVAPGV471del|ELN_uc003tzt.2_In_Frame_Del_p.GVAPGV495del|ELN_uc003tzu.2_In_Frame_Del_p.GVAPGV476del|ELN_uc003tzv.2_In_Frame_Del_p.GVAPGV461del|ELN_uc003tzx.2_In_Frame_Del_p.GVAPGV480del|ELN_uc011kff.1_In_Frame_Del_p.GVAPGV490del|ELN_uc003tzy.2_In_Frame_Del_p.GVAPGV466del	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	519_524	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TCCTGGTGTCGGCGTGGCTCCTGGAGTTGGCGTGGCTC	0.472			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						---	---	---								-	73474250	-	-	73474233	7	5	66	1	0	1	0	1	0	0	0	0	5095	1116	39	0	1537	0	ELN	7	73474233	In_Frame_Del	DEL	GGCGTGGCTCCTGGAGTT	TCGA-CN-5370-01A-01D-2012-08	28463672	73474233	85664430	42	13495											
PEX1	5189	broad.mit.edu	37	chr7	92146635	92146635	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctacatttttggtatatttGatggcattgttcaattcttc	8	21	6	6	0	3	1	1	1	2	0	4	1	3	1	0	2	1	3	0	2	4	10			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr7:92146635G>C	uc003uly.2	-	5	1290	c.1194C>G	c.(1192-1194)ATC>ATG	p.I398M	PEX1_uc011khr.1_Missense_Mutation_p.I190M|PEX1_uc010ley.2_Missense_Mutation_p.I398M|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	398					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TGGTATATTTGATGGCATTGT	0.343													22	110					0	0	0	0	C	92146635	C	C	92146635	3	2	66	1	0	0	0	0	1	0	0	0	11790	1280	45	2	2737	2	PEX1	7	92146635	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	18672402	92146635	66992028	43	13496											
CBWD1	55871	broad.mit.edu	37	chr9	164038	164038	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacatagaagccactgcacCtgaaaatatataatattcat	19	10	4	8	0	1	2	1	1	0	1	1	2	1	2	2	0	3	1	2	0	9	6			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr9:164038C>G	uc003zga.3	-	5	537	c.431_splice	c.e5-1	p.G144_splice	CBWD1_uc010mgs.2_Splice_Site|CBWD1_uc003zgb.3_Splice_Site_p.G108_splice|CBWD1_uc003zgc.3_Splice_Site_p.G144_splice|CBWD1_uc011llr.1_Splice_Site_p.G108_splice	NM_018491	NP_060961	Q9BRT8	CBWD1_HUMAN	COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCCACTGCACCTGAAAATATA	0.269													3	55					0	0	0	0	G	164038	G	G	164038	5	3	66	1	0	0	0	0	0	0	1	0	2724	695	24	4	801	4	CBWD1	9	164038	Splice_Site	SNP	C	TCGA-CN-5370-01A-01D-2012-08		164038	141049393	44	13497											
CDKN2A	1029	broad.mit.edu	37	chr9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcagctccgccactcGggcgctgcccatcatcatga	8	6	10	17	3	2	1	2	1	0	0	4	1	3	1	3	1	4	4	3	1	0	0	rs121913387		TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			12	7					0	0	0	0	A	21971186	A	A	21971186	4	1	66	1	0	0	0	0	0	1	0	0	3176	1125	39	1	306	1	CDKN2A	9	21971186	Nonsense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	21807148	21971186	119242245	45	13498											
CHMP5	51510	broad.mit.edu	37	chr9	33276501	33276501	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atggaagatgcaaatgaaatCcaagaagcactgagtcgcag	17	6	11	7	1	0	4	0	2	0	2	2	5	1	5	1	1	2	3	1	1	5	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr9:33276501C>G	uc003zsl.3	+	7	790	c.435C>G	c.(433-435)ATC>ATG	p.I145M	SUGT1P1_uc010mjq.1_Intron|CHMP5_uc003zsm.3_Missense_Mutation_p.I145M|CHMP5_uc011lnv.1_Missense_Mutation_p.I145M	NM_016410	NP_057494	Q9NZZ3	CHMP5_HUMAN	chromatin modifying protein 5	145	Potential.|Interaction with VTA1.				cellular membrane organization|protein transport	cytosol|endosome membrane	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			CAAATGAAATCCAAGAAGCAC	0.358													10	68					0	0	0	0	G	33276501	G	G	33276501	3	3	66	1	0	0	0	0	1	0	0	0	3374	845	30	2	457	2	CHMP5	9	33276501	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	11305315	33276501	107936930	46	13499											
UNC13B	10497	broad.mit.edu	37	chr9	35389842	35389842	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactgtgtcctctggatcaaGaagcaggagctacctccaga	11	8	10	12	0	2	2	1	0	1	2	4	4	4	4	3	2	3	2	3	2	3	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr9:35389842G>C	uc003zwq.2	+	24	3140	c.2848_splice	c.e24-1	p.K950_splice	UNC13B_uc003zwr.2_Splice_Site_p.K950_splice	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like						excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			TCTGGATCAAGAAGCAGGAGC	0.498													18	196					0	0	0	0	C	35389842	C	C	35389842	5	2	66	1	0	0	0	0	0	0	1	0	17053	956	33	2	2941	2	UNC13B	9	35389842	Splice_Site	SNP	G	TCGA-CN-5370-01A-01D-2012-08	2113341	35389842	105823589	47	13500											
TLN1	7094	broad.mit.edu	37	chr9	35724572	35724572	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctagttctgcttacactCatcatctgtgtgcaatttct	7	19	5	10	0	6	0	2	0	4	0	6	0	6	0	0	0	3	3	0	0	3	5			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr9:35724572C>G	uc003zxt.2	-	5	862	c.508G>C	c.(508-510)GAG>CAG	p.E170Q	TLN1_uc003zxu.3_Missense_Mutation_p.E170Q	NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	170	FERM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGCTTACACTCATCATCTGTG	0.333													244	170					0	0	0	0	G	35724572	G	G	35724572	3	3	66	1	0	0	0	0	1	0	0	0	16013	835	29	2	7329	2	TLN1	9	35724572	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	334730	35724572	105488859	48	13501											
ANXA1	301	broad.mit.edu	37	chr9	75775272	75775272	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgcaatttgatgctgatGaacttcgtgctgccatgaag	10	11	11	9	2	0	4	0	4	0	0	1	4	0	4	1	0	5	3	1	0	3	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr9:75775272G>T	uc004ajf.1	+	5	438	c.364G>T	c.(364-366)GAA>TAA	p.E122*	ANXA1_uc004aje.1_Nonsense_Mutation_p.E122*|ANXA1_uc004ajg.1_Nonsense_Mutation_p.E122*	NM_000700	NP_000691	P04083	ANXA1_HUMAN	annexin I	122					alpha-beta T cell differentiation|anti-apoptosis|cell surface receptor linked signaling pathway|cellular component movement|inflammatory response|keratinocyte differentiation|lipid metabolic process|peptide cross-linking|positive regulation of vesicle fusion	basolateral plasma membrane|cilium|cornified envelope|cytoplasm|extracellular region|nucleus	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity|protein binding, bridging|receptor binding|structural molecule activity			breast(1)|central_nervous_system(1)	2		all_epithelial(88;2.54e-11)		OV - Ovarian serous cystadenocarcinoma(323;2.82e-06)|GBM - Glioblastoma multiforme(74;0.0325)	Alclometasone(DB00240)|Amcinonide(DB00288)|Beclomethasone(DB00394)|Betamethasone(DB00443)|Clobetasol(DB01013)|Clocortolone(DB00838)|Desonide(DB01260)|Desoximetasone(DB00547)|Dexamethasone(DB01234)|Diflorasone(DB00223)|Flumethasone Pivalate(DB00663)|Halobetasol Propionate(DB00596)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mometasone(DB00764)|Prednicarbate(DB01130)|Prednisone(DB00635)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TGATGCTGATGAACTTCGTGC	0.373													14	114					7.93312e-07	9.76384e-07	1	0	T	75775272	T	T	75775272	4	4	66	1	0	0	0	0	0	1	0	0	714	1291	45	2	378	2	ANXA1	9	75775272	Nonsense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	40050700	75775272	65438159	49	13502											
BAAT	570	broad.mit.edu	37	chr9	104130542	104130542	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actggctaggaggctggcccGaaattcaagcagcccaccca	11	5	11	14	1	1	0	1	0	0	0	1	2	1	1	3	4	2	3	3	4	3	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr9:104130542G>A	uc010mtd.2	-	3	638	c.529C>T	c.(529-531)CGG>TGG	p.R177W	BAAT_uc004bbd.3_Missense_Mutation_p.R177W	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	177					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	AGGCTGGCCCGAAATTCAAGC	0.478													7	42					0	0	0	0	A	104130542	A	A	104130542	3	1	66	1	0	0	0	0	1	0	0	0	1282	1057	37	1	735	1	BAAT	9	104130542	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	28355270	104130542	37082889	50	13503											
ABCA1	19	broad.mit.edu	37	chr9	107591238	107591238	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccagcgctcacaagaagagGaatgaggctactaatgaacc	15	5	11	10	1	1	4	1	2	0	2	1	5	1	5	2	2	3	2	2	2	6	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr9:107591238G>T	uc004bcl.2	-	15	2387	c.2074C>A	c.(2074-2076)CCT>ACT	p.P692T		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	692	Helical; (Potential).				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACAAGAAGAGGAATGAGGCTA	0.542													10	45					1.08611e-07	1.34711e-07	1	0	T	107591238	T	T	107591238	3	4	66	1	0	0	0	0	1	0	0	0	28	1174	41	2	4855	2	ABCA1	9	107591238	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	3460696	107591238	33622193	51	13504											
OR1B1	347169	broad.mit.edu	37	chr9	125391138	125391138	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtagaatagcggccccaattCggacataagagagtacaatg	15	7	11	8	2	0	2	0	0	0	2	1	4	0	3	2	2	2	2	2	2	7	5			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr9:125391138C>G	uc011lyz.1	-	1	677	c.677G>C	c.(676-678)CGA>CCA	p.R226P		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCCCCAATTCGGACATAAGA	0.542													5	79					0	0	0	0	G	125391138	G	G	125391138	3	3	66	1	0	0	0	0	1	0	0	0	11005	884	31	3	282	3	OR1B1	9	125391138	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	17799900	125391138	15822293	52	13505											
IL2RA	3559	broad.mit.edu	37	chr10	6066285	6066285	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctttctgttcttcaggttGaggtgtcacttgtttcgttg	3	21	10	7	1	5	1	2	1	3	0	6	1	5	1	0	2	0	4	0	2	0	8			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr10:6066285G>C	uc001iiz.1	-	3	448	c.289C>G	c.(289-291)CAA>GAA	p.Q97E	IL2RA_uc009xih.1_Missense_Mutation_p.Q97E|IL2RA_uc001ija.1_Missense_Mutation_p.Q59E	NM_000417	NP_000408	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha chain precursor	97	Extracellular (Potential).				cell proliferation	integral to membrane	interleukin-2 receptor activity			ovary(1)|skin(1)	2					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	TCTTCAGGTTGAGGTGTCACT	0.423													6	46					0	0	0	0	C	6066285	C	C	6066285	3	2	66	1	0	0	0	0	1	0	0	0	7725	1299	45	2	553	2	IL2RA	10	6066285	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08		6066285	129468462	53	13506											
ITGA8	8516	broad.mit.edu	37	chr10	15628625	15628625	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagtgatgttgatttgcAggctcacaaaattgctgtct	10	13	10	8	0	2	2	1	2	1	0	2	2	2	2	0	1	3	5	0	1	2	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr10:15628625A>G	uc001ioc.1	-	23	2330	c.2330T>C	c.(2329-2331)CTG>CCG	p.L777P	ITGA8_uc010qcb.1_Missense_Mutation_p.L762P	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	777	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GTTGATTTGCAGGCTCACAAA	0.358													8	34					0	0	0	0	G	15628625	G	G	15628625	3	3	66	1	0	0	0	0	1	0	0	0	7921	188	7	5	893	5	ITGA8	10	15628625	Missense_Mutation	SNP	A	TCGA-CN-5370-01A-01D-2012-08	9562340	15628625	119906122	54	13507											
LRIT1	26103	broad.mit.edu	37	chr10	86001255	86001256	+	5'Flank	INS	-	GCCCAGCAA	GCCCAGCAA																															tggaccgctccgtcccaccgINSgcccagcaagctcagcagct																								rs142133495	by1000genomes	TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr10:86001255_86001256insGCCCAGCAA	uc001kcz.1	-						LRIT1_uc001kda.1_RNA	NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL							integral to endoplasmic reticulum membrane					0						CCGTCCCACCGGCCCAGCAAGC	0.653													---	---	---								GCCCAGCAA	86001256	GCCCAGCAA	GCCCAGCAA	86001255	6	5	66	0	1	1	1	0	0	0	0	0	8997	1131	39	0		0	LRIT1	10	86001255	5'Flank	INS	-	TCGA-CN-5370-01A-01D-2012-08	70372630	86001255	49533492	55	13508											
LDB3	11155	broad.mit.edu	37	chr10	88452313	88452313	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaagaccctgatgaagaagCtctgcgaaggtcaaggtaag	14	6	13	8	1	2	4	1	2	1	2	2	5	2	4	1	2	2	3	1	2	6	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr10:88452313C>T	uc001kdv.2	+	6	904	c.881C>T	c.(880-882)GCT>GTT	p.A294V	LDB3_uc010qml.1_Missense_Mutation_p.A294V|LDB3_uc010qmm.1_Missense_Mutation_p.A362V|LDB3_uc001kdu.2_Missense_Mutation_p.A247V|LDB3_uc009xsz.2_Intron|LDB3_uc001kdr.2_Missense_Mutation_p.A247V|LDB3_uc009xsy.2_Missense_Mutation_p.A362V|LDB3_uc001kds.2_Missense_Mutation_p.A294V|LDB3_uc001kdt.2_RNA	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1	294						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						GATGAAGAAGCTCTGCGAAGG	0.602													15	86					0	0	0	0	T	88452313	T	T	88452313	3	4	66	1	0	0	0	0	1	0	0	0	8737	797	28	4	1138	4	LDB3	10	88452313	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	2451058	88452313	47082434	56	13509											
NOLC1	9221	broad.mit.edu	37	chr10	103921945	103921945	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaagtcctttcggcatgaGaaaaccaagaagaagcgggg	14	5	14	8	2	0	3	0	1	0	3	2	4	1	3	2	4	2	2	2	4	6	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr10:103921945G>A	uc001kuo.2	+	13	2254	c.2019G>A	c.(2017-2019)GAG>GAA	p.E673E	NOLC1_uc001kup.2_Silent_p.E683E|NOLC1_uc001kuq.2_Silent_p.E674E|NOLC1_uc009xxb.1_Silent_p.E392E|NOLC1_uc001kur.2_Silent_p.E392E	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	673					mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		TTCGGCATGAGAAAACCAAGA	0.527													55	288					0	0	0	0	A	103921945	A	A	103921945	2	1	66	1	0	0	0	0	0	0	0	1	10583	933	33	2		2	NOLC1	10	103921945	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08	15469632	103921945	31612802	57	13510											
MUC5B	727897	broad.mit.edu	37	chr11	1271810	1271810	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacctccacagtgcttaccgCcacggccaccacaaccgggg	9	4	9	19	3	0	0	0	0	0	0	1	0	1	0	7	3	3	1	7	3	2	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr11:1271810C>A	uc009ycr.1	+	51	15245	c.15119C>A	c.(15118-15120)GCC>GAC	p.A5040D	MUC5B_uc001ltb.2_Missense_Mutation_p.A4570D	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4567	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.			A -> T (in Ref. 4; CAA96577).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTGCTTACCGCCACGGCCACC	0.647													83	240					4.18771e-30	5.49208e-30	1	0	A	1271810	A	A	1271810	3	1	66	1	0	0	0	0	1	0	0	0	10032	739	26	4	13831	4	MUC5B	11	1271810	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08		1271810	133734706	58	13511											
NLRP14	338323	broad.mit.edu	37	chr11	7059962	7059962	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggcctgacaccctggaatGaagtgaagaaggccaggcgg	12	5	15	9	1	0	4	0	3	0	1	0	5	0	5	3	5	0	0	3	5	4	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr11:7059962G>A	uc001mfb.1	+	2	468	c.145G>A	c.(145-147)GAA>AAA	p.E49K		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	49	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ACCCTGGAATGAAGTGAAGAA	0.438													10	85					0	0	0	0	A	7059962	A	A	7059962	3	1	66	1	0	0	0	0	1	0	0	0	10530	1291	45	2	147	2	NLRP14	11	7059962	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	5788152	7059962	127946554	59	13512											
E2F8	79733	broad.mit.edu	37	chr11	19259523	19259523	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcaggttggctgtcggtgTccacggctctccctgagagc	4	12	13	12	2	2	1	1	1	1	1	5	2	3	1	2	4	1	3	2	4	0	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr11:19259523T>C	uc001mpm.2	-	3	694	c.172A>G	c.(172-174)ACA>GCA	p.T58A	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.T58A|E2F8_uc001mpo.1_Missense_Mutation_p.T58A	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	58					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						GCTGTCGGTGTCCACGGCTCT	0.517													3	172					0	0	0	0	C	19259523	C	C	19259523	3	2	66	1	0	0	0	0	1	0	0	0	4895	1667	58	5	2475	5	E2F8	11	19259523	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	12199561	19259523	115746993	60	13513											
LRP4	4038	broad.mit.edu	37	chr11	46917452	46917452	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccttggcacgtgtgcccaTcctctgtgagccggtagcct	5	10	11	15	2	1	1	0	1	1	0	2	1	2	1	5	2	3	2	5	2	1	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr11:46917452T>A	uc001ndn.3	-	10	1312	c.1166A>T	c.(1165-1167)GAT>GTT	p.D389V		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	389	Extracellular (Potential).|EGF-like 1; calcium-binding (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CGTGTGCCCATCCTCTGTGAG	0.557													22	82					0	0	0	0	A	46917452	A	A	46917452	3	1	66	1	0	0	0	0	1	0	0	0	9009	1435	50	5	4667	5	LRP4	11	46917452	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	27657929	46917452	88089064	61	13514											
SLCO2B1	11309	broad.mit.edu	37	chr11	74880401	74880401	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccattcagccctttggcaTctcctacatcgatgactttg	7	13	7	14	1	2	1	1	1	1	0	4	2	2	1	3	1	2	1	3	1	1	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr11:74880401T>G	uc001owb.2	+	5	1019	c.632T>G	c.(631-633)ATC>AGC	p.I211S	SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Missense_Mutation_p.I67S|SLCO2B1_uc010rrs.1_Missense_Mutation_p.I95S|SLCO2B1_uc001owc.2_Intron|SLCO2B1_uc001owd.2_Missense_Mutation_p.I189S	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	211	Helical; Name=4; (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	CCCTTTGGCATCTCCTACATC	0.597													9	92					0	0	0	0	G	74880401	G	G	74880401	3	3	66	1	0	0	0	0	1	0	0	0	14791	1435	50	5	650	5	SLCO2B1	11	74880401	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	27962949	74880401	60126115	62	13515											
GRIN2B	2904	broad.mit.edu	37	chr12	13717534	13717534	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagttcattacagactggcGctcctcgatcgccaccccat	8	9	9	15	3	1	1	1	0	0	1	4	3	2	2	4	2	1	2	4	2	1	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr12:13717534G>A	uc001rbt.2	-	13	2817	c.2638C>T	c.(2638-2640)CGC>TGC	p.R880C		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	880	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACAGACTGGCGCTCCTCGATC	0.537													24	125					0	0	0	0	A	13717534	A	A	13717534	3	1	66	1	0	0	0	0	1	0	0	0	6819	1087	38	1	1820	1	GRIN2B	12	13717534	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08		13717534	120134361	63	13516											
PTPRO	5800	broad.mit.edu	37	chr12	15722430	15722430	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataaattttctcttcagtttGaggtgagttggttaaggcat	10	17	10	4	0	2	2	1	2	1	0	3	2	2	2	0	3	0	4	0	3	3	7			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr12:15722430G>C	uc001rcv.1	+	19	3001	c.2827G>C	c.(2827-2829)GAG>CAG	p.E943Q	PTPRO_uc001rcw.1_Missense_Mutation_p.E915Q|PTPRO_uc001rcx.1_Missense_Mutation_p.E132Q|PTPRO_uc001rcy.1_Missense_Mutation_p.E132Q|PTPRO_uc001rcz.1_Missense_Mutation_p.E104Q|PTPRO_uc001rda.1_Missense_Mutation_p.E104Q	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	943	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				TCTTCAGTTTGAGGTGAGTTG	0.448													4	49					0	0	0	0	C	15722430	C	C	15722430	3	2	66	1	0	0	0	0	1	0	0	0	12874	1291	45	2	2901	2	PTPRO	12	15722430	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	2004896	15722430	118129465	64	13517											
MLL2	8085	broad.mit.edu	37	chr12	49420564	49420564	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccgtggaccaaagggcaCagttgaggtgcacccacagg	10	5	13	13	1	0	1	0	1	0	0	1	2	1	2	4	4	1	3	4	4	1	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr12:49420564C>A	uc001rta.3	-	48	15185	c.15185G>T	c.(15184-15186)TGT>TTT	p.C5062F		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5062					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCAAAGGGCACAGTTGAGGTG	0.617			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			19	91					2.4624e-09	3.10223e-09	1	0	A	49420564	A	A	49420564	3	1	66	1	0	0	0	0	1	0	0	0	9674	478	17	4	1456	4	MLL2	12	49420564	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	33698134	49420564	84431331	65	13518											
TPH2	121278	broad.mit.edu	37	chr12	72425343	72425343	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtcccttctcagtatacttCaatccctacacacagagtat	11	12	4	14	1	2	1	2	0	1	1	5	1	4	1	2	0	2	2	2	0	5	6			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr12:72425343C>T	uc009zrw.1	+	11	1482	c.1341C>T	c.(1339-1341)TTC>TTT	p.F447F	TPH2_uc001swy.2_Silent_p.F357F	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	447					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	CAGTATACTTCAATCCCTACA	0.423													8	55					0	0	0	0	T	72425343	T	T	72425343	2	4	66	1	0	0	0	0	0	0	0	1	16469	825	29	2		2	TPH2	12	72425343	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08	23004779	72425343	61426552	66	13519											
GALNT4	8693	broad.mit.edu	37	chr12	89919631	89919632	+	5'Flank	DEL	CC	-	-																															ggacaggctccagggagggaCcccccccacctccaacccgt																								rs67346689		TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr12:89919631_89919632delCC	uc001tbd.2	-						POC1B_uc001tba.2_5'Flank|POC1B_uc001tbb.2_5'Flank|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Intron|GALNT4_uc010suo.1_Intron	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4						carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						CAGGGAGGGACCCCCCCCACCT	0.668													---	---	---								-	89919632	-	-	89919631	6	5	66	0	1	1	0	1	0	0	0	0	6250	522	18	0		0	GALNT4	12	89919631	5'Flank	DEL	CC	TCGA-CN-5370-01A-01D-2012-08	17494288	89919631	43932264	67	13520											
RFX4	5992	broad.mit.edu	37	chr12	107126831	107126831	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttcccctgttagcaatcCttcccctgagtacactggcc	6	12	6	17	0	1	1	0	1	1	0	4	1	4	1	6	1	2	3	6	1	3	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr12:107126831C>A	uc001tlr.2	+	15	1667	c.1601C>A	c.(1600-1602)CCT>CAT	p.P534H	RFX4_uc001tls.2_Missense_Mutation_p.P543H|RFX4_uc001tlt.2_Missense_Mutation_p.P543H|RFX4_uc001tlv.2_Missense_Mutation_p.P440H	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	534					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						GTTAGCAATCCTTCCCCTGAG	0.478													5	188					0.00116845	0.00138482	1	0	A	107126831	A	A	107126831	3	1	66	1	0	0	0	0	1	0	0	0	13330	681	24	4	1832	4	RFX4	12	107126831	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	17207200	107126831	26725064	68	13521											
SSH1	54434	broad.mit.edu	37	chr12	109201543	109201543	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagatgagagctacacccccGgggaagtagttgtgcctccg	9	7	13	12	2	0	2	0	1	0	2	1	4	1	3	4	2	3	3	4	2	3	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr12:109201543G>A	uc001tnm.2	-	8	684	c.597C>T	c.(595-597)CCC>CCT	p.P199P	SSH1_uc001tnl.2_5'Flank|SSH1_uc010sxg.1_Silent_p.P210P|SSH1_uc001tnn.3_Silent_p.P199P|SSH1_uc001tno.1_Silent_p.P103P	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	199					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						CTACACCCCCGGGGAAGTAGT	0.612													25	68					0	0	0	0	A	109201543	A	A	109201543	2	1	66	1	0	0	0	0	0	0	0	1	15250	1103	39	1		1	SSH1	12	109201543	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08	2074712	109201543	24650352	69	13522											
TPTE2	93492	broad.mit.edu	37	chr13	20041462	20041462	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtatctaaaatgttaaataAgtcagaaaaatactgctgtc	18	12	6	5	0	2	1	1	0	1	1	3	1	2	1	0	0	2	3	0	0	9	5			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr13:20041462A>G	uc001umd.2	-	8	626	c.415T>C	c.(415-417)TTA>CTA	p.L139L	TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Intron|TPTE2_uc001ume.2_Intron|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	139						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ATGTTAAATAAGTCAGAAAAA	0.303													8	28					0	0	0	0	G	20041462	G	G	20041462	2	3	66	1	0	0	0	0	0	0	0	1	16498	69	3	5		5	TPTE2	13	20041462	Silent	SNP	A	TCGA-CN-5370-01A-01D-2012-08		20041462	95128416	70	13523											
DZIP1	22873	broad.mit.edu	37	chr13	96237020	96237020	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggccccttaggattaaatgCgccccaggcatttagcacat	10	10	9	12	1	0	0	0	0	0	0	0	1	0	1	4	3	2	2	4	3	4	4	rs147653120		TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr13:96237020C>T	uc001vmk.2	-	22	3346	c.2494G>A	c.(2494-2496)GCA>ACA	p.A832T	DZIP1_uc001vmi.2_Missense_Mutation_p.A80T|DZIP1_uc001vmj.2_Missense_Mutation_p.A308T|DZIP1_uc001vml.2_Missense_Mutation_p.A813T|DZIP1_uc001vmm.2_5'Flank	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	832					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			GGATTAAATGCGCCCCAGGCA	0.408													38	90					0	0	0	0	T	96237020	T	T	96237020	3	4	66	1	0	0	0	0	1	0	0	0	4885	768	27	1	117	1	DZIP1	13	96237020	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	76195558	96237020	18932858	71	13524											
TMTC4	84899	broad.mit.edu	37	chr13	101289875	101289875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtgcccatgatcctccagcGcacgtagagcatcccagccc	8	6	9	18	3	0	2	0	1	0	1	3	2	3	2	5	0	4	3	5	0	1	1	rs141063052		TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr13:101289875G>A	uc001vou.2	-	8	1019	c.859C>T	c.(859-861)CGC>TGC	p.R287C	TMTC4_uc001vot.2_Missense_Mutation_p.R306C|TMTC4_uc010tja.1_Missense_Mutation_p.R176C|TMTC4_uc001vov.1_Missense_Mutation_p.R32C|TMTC4_uc001vow.1_Missense_Mutation_p.R70C	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	287	Helical; (Potential).					integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ATCCTCCAGCGCACGTAGAGC	0.627													10	126					0	0	0	0	A	101289875	A	A	101289875	3	1	66	1	0	0	0	0	1	0	0	0	16329	1087	38	1	1410	1	TMTC4	13	101289875	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	5052855	101289875	13880003	72	13525											
CCNB1IP1	57820	broad.mit.edu	37	chr14	20781879	20781879	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccttgctttgtatttgctGagtatatatcttctccatct	7	20	5	9	0	3	1	0	1	3	0	5	1	4	1	2	0	2	4	2	0	4	8			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr14:20781879G>A	uc001vwv.2	-	6	1028	c.379C>T	c.(379-381)CAG>TAG	p.Q127*	CCNB1IP1_uc001vww.2_Nonsense_Mutation_p.Q127*|CCNB1IP1_uc001vwx.2_Nonsense_Mutation_p.Q127*|CCNB1IP1_uc001vwy.2_Nonsense_Mutation_p.Q127*|CCNB1IP1_uc001vwz.2_Nonsense_Mutation_p.Q127*	NM_182851	NP_878271	Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1 isoform 3	127	Potential.					chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	soft_tissue(2)|ovary(1)	3	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)		TGTATTTGCTGAGTATATATC	0.383			T	HMGA2	leiomyoma								6	46					0	0	0	0	A	20781879	A	A	20781879	4	1	66	1	0	0	0	0	0	1	0	0	2927	1299	45	2	462	2	CCNB1IP1	14	20781879	Nonsense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08		20781879	86567661	73	13526											
OR6S1	341799	broad.mit.edu	37	chr14	21109439	21109439	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcacacagccccactcaTgagcaaggggtagcgcagag	14	3	12	12	1	1	2	1	1	0	1	1	2	1	2	2	2	4	4	2	2	3	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr14:21109439T>C	uc001vxv.1	-	1	412	c.412A>G	c.(412-414)ATG>GTG	p.M138V		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		GCCCCACTCATGAGCAAGGGG	0.587													14	54					0	0	0	0	C	21109439	C	C	21109439	3	2	66	1	0	0	0	0	1	0	0	0	11263	1464	51	5	587	5	OR6S1	14	21109439	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	327560	21109439	86240101	74	13527											
ZFP36L1	677	broad.mit.edu	37	chr14	69257036	69257036	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtctcgcgagctcagagcGggggctggctcacccttgag	5	8	15	13	3	3	2	2	1	1	1	4	3	3	2	1	3	2	3	1	3	0	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr14:69257036G>A	uc001xkh.1	-	2	361	c.231C>T	c.(229-231)CCC>CCT	p.P77P	ZFP36L1_uc001xki.1_Silent_p.P77P	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	77					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AGCTCAGAGCGGGGGCTGGCT	0.692											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	47					0	0	0	0	A	69257036	A	A	69257036	2	1	66	1	0	0	0	0	0	0	0	1	17713	1103	39	1		1	ZFP36L1	14	69257036	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08	48147597	69257036	38092504	75	13528											
EXD2	55218	broad.mit.edu	37	chr14	69701563	69701563	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaaaatgccagggtgtggtCgacatcccatttcgaagcaa	13	8	11	9	2	0	0	0	0	0	0	3	3	1	0	2	2	2	1	2	2	4	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr14:69701563C>T	uc001xkt.2	+	7	1148	c.489C>T	c.(487-489)GTC>GTT	p.V163V	EXD2_uc001xku.2_Silent_p.V33V|EXD2_uc001xkv.2_Silent_p.V288V|EXD2_uc001xkw.2_Silent_p.V163V|EXD2_uc010aqt.2_Silent_p.V288V|EXD2_uc010tte.1_Silent_p.V288V|EXD2_uc001xky.2_Silent_p.V163V	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	163					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						AGGGTGTGGTCGACATCCCAT	0.433													13	55					0	0	0	0	T	69701563	T	T	69701563	2	4	66	1	0	0	0	0	0	0	0	1	5322	871	31	1		1	EXD2	14	69701563	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08	444527	69701563	37647977	76	13529											
DYNC1H1	1778	broad.mit.edu	37	chr14	102516786	102516786	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcaggtaaccttacctgtCtacctgaacttcacccgtgc	8	11	7	15	1	2	1	1	1	1	0	2	1	2	1	4	1	6	2	4	1	4	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr14:102516786C>G	uc001yks.2	+	78	13991	c.13827C>G	c.(13825-13827)GTC>GTG	p.V4609V		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4609					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CCTTACCTGTCTACCTGAACT	0.542													34	266					0	0	0	0	G	102516786	G	G	102516786	2	3	66	1	0	0	0	0	0	0	0	1	4863	900	32	2		2	DYNC1H1	14	102516786	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08	32815223	102516786	4832754	77	13530											
TRPM1	4308	broad.mit.edu	37	chr15	31294456	31294456	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtcaattgctggtccgtgaTtgaactgtactctacatcct	8	14	8	11	2	2	2	1	2	1	0	4	2	4	2	2	1	4	2	2	1	4	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr15:31294456T>C	uc001zfm.2	-	27	4509	c.4381A>G	c.(4381-4383)ATC>GTC	p.I1461V	TRPM1_uc010azy.2_Missense_Mutation_p.I1368V|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1461	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TGGTCCGTGATTGAACTGTAC	0.468													35	120					0	0	0	0	C	31294456	C	C	31294456	3	2	66	1	0	0	0	0	1	0	0	0	16652	1493	52	5	434	5	TRPM1	15	31294456	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08		31294456	71236936	78	13531											
ATP8B4	79895	broad.mit.edu	37	chr15	50212513	50212513	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctcttctgtggcagcattcGcatcttcaagcatcttatgc	7	15	7	12	1	5	0	1	0	4	0	7	0	5	0	0	1	3	4	0	1	2	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr15:50212513G>A	uc001zxu.2	-	18	1995	c.1853C>T	c.(1852-1854)GCG>GTG	p.A618V	ATP8B4_uc010ber.2_Missense_Mutation_p.A491V|ATP8B4_uc010ufd.1_Missense_Mutation_p.A428V|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	618	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GGCAGCATTCGCATCTTCAAG	0.448													9	84					0	0	0	0	A	50212513	A	A	50212513	3	1	66	1	0	0	0	0	1	0	0	0	1199	1087	38	1	1769	1	ATP8B4	15	50212513	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	18918057	50212513	52318879	79	13532											
UACA	55075	broad.mit.edu	37	chr15	70960742	70960742	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttctattaagatcatcaaTaattgcatcatgtgactttt	12	18	4	7	0	4	2	3	1	1	1	4	2	4	2	0	0	1	1	0	0	4	7			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr15:70960742T>C	uc002asr.2	-	16	2385	c.2281A>G	c.(2281-2283)ATT>GTT	p.I761V	UACA_uc010uke.1_Missense_Mutation_p.I652V|UACA_uc002asq.2_Missense_Mutation_p.I748V|UACA_uc010bin.1_Missense_Mutation_p.I736V	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	761	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						AGATCATCAATAATTGCATCA	0.303													11	37					0	0	0	0	C	70960742	C	C	70960742	3	2	66	1	0	0	0	0	1	0	0	0	16892	1406	49	5	1985	5	UACA	15	70960742	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	20748229	70960742	31570650	80	13533											
TMEM202	338949	broad.mit.edu	37	chr15	72698993	72698993	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcatctctgtctttaccataCttactggccttggctggctc	5	16	7	13	0	3	0	1	0	2	0	5	0	3	0	2	3	3	2	2	3	3	5			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr15:72698993C>T	uc002auq.2	+	3	388	c.388C>T	c.(388-390)CTT>TTT	p.L130F	TMEM202_uc002aur.2_RNA	NM_001080462	NP_001073931	A6NGA9	TM202_HUMAN	transmembrane protein 202	130	Helical; (Potential).					integral to membrane				central_nervous_system(1)|skin(1)	2						CTTTACCATACTTACTGGCCT	0.478													20	122					0	0	0	0	T	72698993	T	T	72698993	3	4	66	1	0	0	0	0	1	0	0	0	16193	565	20	4	398	4	TMEM202	15	72698993	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	1738251	72698993	29832399	81	13534											
KIAA1199	57214	broad.mit.edu	37	chr15	81173350	81173350	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaagctctcctggacatttCtgaacaagacccttcaccca	13	9	5	14	0	3	2	1	1	2	1	4	3	3	3	3	1	2	1	3	1	4	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr15:81173350C>A	uc002bfw.1	+	5	750	c.490C>A	c.(490-492)CTG>ATG	p.L164M	KIAA1199_uc010unn.1_Missense_Mutation_p.L164M	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	164	G8.									upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTGGACATTTCTGAACAAGAC	0.493													24	129					7.33532e-06	8.8913e-06	1	0	A	81173350	A	A	81173350	3	1	66	1	0	0	0	0	1	0	0	0	8252	912	32	2	504	2	KIAA1199	15	81173350	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	8474357	81173350	21358042	82	13535											
CHSY1	22856	broad.mit.edu	37	chr15	101775715	101775715	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tagtggcactactggaattgGtacagatgtgtcagaaccct	11	11	11	8	0	1	2	1	0	0	2	1	3	1	3	1	3	3	2	1	3	5	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr15:101775715G>C	uc002bwt.1	-	3	871	c.388C>G	c.(388-390)CCA>GCA	p.P130A		NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	130	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ACTGGAATTGGTACAGATGTG	0.458													25	102					0	0	0	0	C	101775715	C	C	101775715	3	2	66	1	0	0	0	0	1	0	0	0	3427	1261	44	4	2028	4	CHSY1	15	101775715	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	20602365	101775715	755677	83	13536											
ADCY9	115	broad.mit.edu	37	chr16	4164292	4164292	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgatctgctgcatcttaaaAgggcggaaggctataggagc	11	9	13	8	2	2	0	0	0	2	0	3	3	2	2	0	4	3	3	0	4	5	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr16:4164292A>G	uc002cvx.2	-	2	1691	c.1152T>C	c.(1150-1152)CCT>CCC	p.P384P		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	384	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						GCATCTTAAAAGGGCGGAAGG	0.488													3	133					0	0	0	0	G	4164292	G	G	4164292	2	3	66	1	0	0	0	0	0	0	0	1	301	59	3	5		5	ADCY9	16	4164292	Silent	SNP	A	TCGA-CN-5370-01A-01D-2012-08		4164292	86190461	84	13537											
ADCY9	115	broad.mit.edu	37	chr16	4164320	4164320	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctataggagctttttggAtggaagactttttcttcctg	8	16	11	6	0	1	1	0	0	1	1	2	4	2	4	1	4	1	2	1	4	3	7			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr16:4164320A>T	uc002cvx.2	-	2	1663	c.1124T>A	c.(1123-1125)ATC>AAC	p.I375N		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	375	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						AGCTTTTTGGATGGAAGACTT	0.463													33	111					0	0	0	0	T	4164320	T	T	4164320	3	4	66	1	0	0	0	0	1	0	0	0	301	333	12	5	2977	5	ADCY9	16	4164320	Missense_Mutation	SNP	A	TCGA-CN-5370-01A-01D-2012-08	28	4164320	86190433	85	13538											
ABCC12	94160	broad.mit.edu	37	chr16	48173139	48173139	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtgggccccagaatgaaaaAggcgtacgccgcacaaaaga	15	4	12	10	3	0	3	0	1	0	2	0	3	0	3	3	2	1	2	3	2	6	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr16:48173139A>G	uc002efc.1	-	5	1112	c.766T>C	c.(766-768)TTT>CTT	p.F256L	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Missense_Mutation_p.F256L|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	256	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				AGAATGAAAAAGGCGTACGCC	0.473													3	114					0	0	0	0	G	48173139	G	G	48173139	3	3	66	1	0	0	0	0	1	0	0	0	52	72	3	5	3413	5	ABCC12	16	48173139	Missense_Mutation	SNP	A	TCGA-CN-5370-01A-01D-2012-08	44008819	48173139	42181614	86	13539											
NFATC3	4775	broad.mit.edu	37	chr16	68156924	68156924	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagatgatggccttggatctCagtatcctttaaagaaagat	13	13	9	6	0	1	4	1	1	1	3	3	5	2	5	2	2	0	1	2	2	5	5			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr16:68156924C>G	uc002evo.1	+	2	1348	c.1138C>G	c.(1138-1140)CAG>GAG	p.Q380E	NFATC3_uc010vkl.1_5'UTR|NFATC3_uc010vkm.1_5'UTR|NFATC3_uc010vkn.1_5'UTR|NFATC3_uc010vko.1_5'UTR|NFATC3_uc010vkp.1_5'UTR|NFATC3_uc010vkq.1_5'UTR|NFATC3_uc002evl.2_Intron|NFATC3_uc002evk.2_Missense_Mutation_p.Q380E|NFATC3_uc002evm.1_Missense_Mutation_p.Q380E|NFATC3_uc002evn.1_Missense_Mutation_p.Q380E|NFATC3_uc010vkr.1_5'UTR|NFATC3_uc010vks.1_5'UTR|NFATC3_uc010vkt.1_5'UTR|NFATC3_uc010vku.1_5'UTR|NFATC3_uc010vkv.1_5'UTR|NFATC3_uc010vkw.1_5'UTR|NFATC3_uc010vkx.1_5'UTR|NFATC3_uc010vky.1_5'UTR|NFATC3_uc010vkz.1_5'UTR|NFATC3_uc010vla.1_5'UTR|NFATC3_uc010vlb.1_5'UTR|NFATC3_uc010vlc.1_5'UTR	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	380					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		CCTTGGATCTCAGTATCCTTT	0.453													20	115					0	0	0	0	G	68156924	G	G	68156924	3	3	66	1	0	0	0	0	1	0	0	0	10418	827	29	2	1144	2	NFATC3	16	68156924	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	19983785	68156924	22197829	87	13540											
CA5A	763	broad.mit.edu	37	chr16	87960541	87960541	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggagaccgggaccgtccaGagtgggtgcactgcagggag	9	4	18	10	3	0	2	0	0	0	2	1	5	1	4	3	4	2	2	3	4	0	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr16:87960541G>C	uc002fkn.1	-	2	209	c.153C>G	c.(151-153)CTC>CTG	p.L51L		NM_001739	NP_001730	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial precursor	51					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0513)		GGACCGTCCAGAGTGGGTGCA	0.632													2	7					0	0	0	0	C	87960541	C	C	87960541	2	2	66	1	0	0	0	0	0	0	0	1	2531	929	33	2		2	CA5A	16	87960541	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08	19803617	87960541	2394212	88	13541											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	7	7	13	14	3	3	0	3	0	0	0	4	0	4	0	3	3	3	2	3	3	1	0	rs28934578		TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	58					0	0	0	0	T	7578406	T	T	7578406	3	4	66	1	0	0	0	0	1	0	0	0	16448	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08		7578406	73616804	89	13542											
TP53	7157	broad.mit.edu	37	chr17	7578555	7578555	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgttgagggcaggggagtaCtgtaggaagaggaaggagac	12	7	19	3	0	0	3	0	1	0	2	0	7	0	6	0	6	1	4	0	6	4	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:7578555C>T	uc002gim.2	-	5	570	c.376_splice	c.e5-1	p.Y126_splice	TP53_uc002gig.1_Splice_Site_p.Y126_splice|TP53_uc002gih.2_Splice_Site_p.Y126_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Splice_Site_p.Y126_splice|TP53_uc010cni.1_Splice_Site_p.Y126_splice|TP53_uc002gij.2_Splice_Site_p.Y126_splice|TP53_uc010cnj.1_Splice_Site|TP53_uc002gin.2_Splice_Site_p.Y33_splice|TP53_uc002gio.2_Splice_Site|TP53_uc010vug.1_Splice_Site_p.Y87_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(31)|p.0?(7)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGGAGTACTGTAGGAAGA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	22					0	0	0	0	T	7578555	T	T	7578555	5	4	66	1	0	0	0	0	0	0	1	0	16448	579	20	4	923	4	TP53	17	7578555	Splice_Site	SNP	C	TCGA-CN-5370-01A-01D-2012-08	149	7578555	73616655	90	13543											
DNAH9	1770	broad.mit.edu	37	chr17	11556233	11556233	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggaaaaagggaatcccttCtttctctggatgatcggcat	11	12	10	8	1	2	1	0	1	2	0	5	4	3	4	1	4	0	1	1	4	3	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:11556233C>G	uc002gne.2	+	14	2577	c.2509C>G	c.(2509-2511)CTT>GTT	p.L837V	DNAH9_uc010coo.2_Missense_Mutation_p.L131V	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	837	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGAATCCCTTCTTTCTCTGGA	0.388													18	53					0	0	0	0	G	11556233	G	G	11556233	3	3	66	1	0	0	0	0	1	0	0	0	4630	913	32	2	2563	2	DNAH9	17	11556233	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	3977678	11556233	69638977	91	13544											
CYTSB	92521	broad.mit.edu	37	chr17	20109115	20109115	+	Frame_Shift_Del	DEL	A	-	-																															gcgaagttcaagaaatgttgAaagtagcccgagcagagaaa																										TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:20109115delA	uc002gwq.2	+	4	1898	c.1753delA	c.(1753-1755)AAAfs	p.K585fs	CYTSB_uc010cqx.2_Frame_Shift_Del_p.K585fs|CYTSB_uc002gwr.2_Frame_Shift_Del_p.K585fs|CYTSB_uc002gws.2_Frame_Shift_Del_p.K585fs|CYTSB_uc002gwv.2_Frame_Shift_Del_p.K504fs|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Frame_Shift_Del_p.K361fs|CYTSB_uc002gwt.2_Frame_Shift_Del_p.K504fs|CYTSB_uc002gwu.2_Frame_Shift_Del_p.K504fs	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	585	Potential.					nucleus					0						AGAAATGTTGAAAGTAGCCCG	0.458													---	---	---								-	20109115	-	-	20109115	7	5	66	1	0	1	0	1	0	0	0	0	4227	247	9	0	1807	0	CYTSB	17	20109115	Frame_Shift_Del	DEL	A	TCGA-CN-5370-01A-01D-2012-08	8552882	20109115	61086095	92	13545											
NEK8	284086	broad.mit.edu	37	chr17	27068133	27068133	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttttggcagcaatcagcaCggacagttgggcaccaatac	12	8	10	11	1	1	0	1	0	0	0	1	1	1	1	1	3	3	5	1	3	3	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:27068133C>T	uc002hcp.2	+	13	1770	c.1770C>T	c.(1768-1770)CAC>CAT	p.H590H	TRAF4_uc002hcq.1_5'Flank|TRAF4_uc002hcs.2_5'Flank	NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	590	RCC1 4.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					GCAATCAGCACGGACAGTTGG	0.582													28	118					0	0	0	0	T	27068133	T	T	27068133	2	4	66	1	0	0	0	0	0	0	0	1	10384	535	19	1		1	NEK8	17	27068133	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08	6959018	27068133	54127077	93	13546											
SEZ6	124925	broad.mit.edu	37	chr17	27286791	27286791	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatgatgatggagccctgctCcagggtgtagccagggtcgc	7	8	16	10	1	0	2	0	2	0	0	2	4	1	3	3	3	3	2	3	3	1	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:27286791C>G	uc002hdp.2	-	8	1890	c.1696G>C	c.(1696-1698)GAG>CAG	p.E566Q	SEZ6_uc010crx.1_5'Flank|SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.E566Q|SEZ6_uc002hdq.1_Missense_Mutation_p.E441Q	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	566	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			GAGCCCTGCTCCAGGGTGTAG	0.587													5	49					0	0	0	0	G	27286791	G	G	27286791	3	3	66	1	0	0	0	0	1	0	0	0	14207	864	30	2	1341	2	SEZ6	17	27286791	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	218658	27286791	53908419	94	13547											
SGCA	6442	broad.mit.edu	37	chr17	48243421	48243421	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catggctgagacactcttctGgactcctctcctcgtgggca	6	11	10	14	1	3	1	0	1	3	1	6	3	4	2	2	3	0	2	2	3	0	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:48243421G>A	uc002iqi.2	+	1	56	c.20G>A	c.(19-21)TGG>TAG	p.W7*	SGCA_uc010wmh.1_5'UTR|SGCA_uc002iqj.2_Nonsense_Mutation_p.W7*|SGCA_uc010wmi.1_RNA	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	7					muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						ACACTCTTCTGGACTCCTCTC	0.517													13	233					0	0	0	0	A	48243421	A	A	48243421	4	1	66	1	0	0	0	0	0	1	0	0	14264	1357	47	4	22	4	SGCA	17	48243421	Nonsense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	20956630	48243421	32951789	95	13548											
CACNA1G	8913	broad.mit.edu	37	chr17	48695588	48695588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccctcctcccccagagtgtGacgagacacacccctgtgag	8	7	9	17	1	0	4	0	2	0	2	3	5	3	4	6	0	0	0	6	0	0	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:48695588G>A	uc002irk.1	+	32	5683	c.5311G>A	c.(5311-5313)GAC>AAC	p.D1771N	CACNA1G_uc002irj.1_Missense_Mutation_p.D1737N|CACNA1G_uc002irl.1_Missense_Mutation_p.D1748N|CACNA1G_uc002irm.1_Missense_Mutation_p.D1737N|CACNA1G_uc002irn.1_Missense_Mutation_p.D1730N|CACNA1G_uc002iro.1_Missense_Mutation_p.D1737N|CACNA1G_uc002irp.1_Missense_Mutation_p.D1771N|CACNA1G_uc002irq.1_Missense_Mutation_p.D1748N|CACNA1G_uc002irr.1_Missense_Mutation_p.D1771N|CACNA1G_uc002irs.1_Missense_Mutation_p.D1760N|CACNA1G_uc002irt.1_Missense_Mutation_p.D1753N|CACNA1G_uc002irv.1_Missense_Mutation_p.D1760N|CACNA1G_uc002irw.1_Missense_Mutation_p.D1748N|CACNA1G_uc002iru.1_Missense_Mutation_p.D1737N|CACNA1G_uc002irx.1_Missense_Mutation_p.D1684N|CACNA1G_uc002iry.1_Missense_Mutation_p.D1673N|CACNA1G_uc002irz.1_Missense_Mutation_p.D1677N|CACNA1G_uc002isa.1_Missense_Mutation_p.D1650N|CACNA1G_uc002isb.1_Missense_Mutation_p.D1691N|CACNA1G_uc002isc.1_Missense_Mutation_p.D1673N|CACNA1G_uc002isd.1_Missense_Mutation_p.D1659N|CACNA1G_uc002ise.1_Missense_Mutation_p.D1639N|CACNA1G_uc002isf.1_Missense_Mutation_p.D1666N|CACNA1G_uc002isg.1_Missense_Mutation_p.D1632N|CACNA1G_uc002ish.1_Missense_Mutation_p.D1639N|CACNA1G_uc002isi.1_Missense_Mutation_p.D1627N	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1771	IV.|Extracellular (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCCAGAGTGTGACGAGACACA	0.622													22	66					0	0	0	0	A	48695588	A	A	48695588	3	1	66	1	0	0	0	0	1	0	0	0	2556	1290	45	2	5704	2	CACNA1G	17	48695588	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	452167	48695588	32499622	96	13549											
TEX14	56155	broad.mit.edu	37	chr17	56676800	56676800	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctcctggaggctcttctaTgtcatcttccaaaatcaagc	10	12	7	12	0	5	0	2	0	3	0	7	1	7	1	2	2	2	2	2	2	4	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:56676800T>C	uc010dcz.1	-	14	2042	c.1924A>G	c.(1924-1926)ATA>GTA	p.I642V	TEX14_uc002iwr.1_Missense_Mutation_p.I636V|TEX14_uc002iws.1_Missense_Mutation_p.I636V|TEX14_uc010dda.1_Missense_Mutation_p.I416V	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	642						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGCTCTTCTATGTCATCTTCC	0.502													18	77					0	0	0	0	C	56676800	C	C	56676800	3	2	66	1	0	0	0	0	1	0	0	0	15844	1464	51	5	2649	5	TEX14	17	56676800	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	7981212	56676800	24518410	97	13550											
ABCA6	23460	broad.mit.edu	37	chr17	67094139	67094139	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aataagaaaaaggaaccatcCggcaacccagtccagagtcc	17	4	8	12	1	0	2	0	0	0	2	3	3	3	3	5	2	2	1	5	2	6	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:67094139C>T	uc002jhw.1	-	23	3217	c.3042G>A	c.(3040-3042)CCG>CCA	p.P1014P		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1014	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					AGGAACCATCCGGCAACCCAG	0.358													6	25					0	0	0	0	T	67094139	T	T	67094139	2	4	66	1	0	0	0	0	0	0	0	1	36	639	23	1		1	ABCA6	17	67094139	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08	10417339	67094139	14101071	98	13551											
LLGL2	3993	broad.mit.edu	37	chr17	73568022	73568022	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgggcgccggtggtgggcatCctggtgctcgacggacacag	5	6	18	12	5	0	0	0	0	0	0	2	2	1	1	2	6	1	2	2	6	0	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:73568022C>A	uc002joh.2	+	19	2491	c.2337C>A	c.(2335-2337)ATC>ATA	p.I779I	LLGL2_uc002joi.2_Silent_p.I779I|LLGL2_uc010dgg.1_Silent_p.I779I|LLGL2_uc002joj.2_Silent_p.I768I|LLGL2_uc010wsd.1_Silent_p.I406I	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	779	WD 12.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			TGGTGGGCATCCTGGTGCTCG	0.667													7	31					0.00198382	0.0023339	1	0	A	73568022	A	A	73568022	2	1	66	1	0	0	0	0	0	0	0	1	8876	845	30	2		2	LLGL2	17	73568022	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08	6473883	73568022	7627188	99	13552											
ST6GALNAC1	55808	broad.mit.edu	37	chr17	74639688	74639688	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaccactggacgccttggctCaggtgcctgcatctccacag	7	8	11	15	1	2	0	1	0	1	0	3	2	2	1	4	3	2	2	4	3	0	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:74639688C>G	uc002jsh.2	-	1	207	c.33G>C	c.(31-33)CTG>CTC	p.L11L	ST6GALNAC1_uc002jsi.2_5'UTR|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	11	Cytoplasmic (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						CGCCTTGGCTCAGGTGCCTGC	0.562													6	28					0	0	0	0	G	74639688	G	G	74639688	2	3	66	1	0	0	0	0	0	0	0	1	15289	813	29	2		2	ST6GALNAC1	17	74639688	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08	1071666	74639688	6555522	100	13553											
SOCS3	9021	broad.mit.edu	37	chr17	76354904	76354904	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcacactggatgcgcaggttCttggtcccagactgggtctt	6	12	12	11	1	3	1	1	0	2	1	4	2	4	2	1	4	1	2	1	4	0	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr17:76354904C>T	uc002jvl.2	-	2	689	c.273G>A	c.(271-273)AAG>AAA	p.K91K		NM_003955	NP_003946	O14543	SOCS3_HUMAN	suppressor of cytokine signaling 3	91	SH2.				anti-apoptosis|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|regulation of growth|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol	protein kinase inhibitor activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.000688)|OV - Ovarian serous cystadenocarcinoma(97;0.0554)			TGCGCAGGTTCTTGGTCCCAG	0.657													7	35					0	0	0	0	T	76354904	T	T	76354904	2	4	66	1	0	0	0	0	0	0	0	1	14979	912	32	2		2	SOCS3	17	76354904	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08	1715216	76354904	4840306	101	13554											
PTPRS	5802	broad.mit.edu	37	chr19	5210481	5210481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctgtctcttcactcaccCgggcatctgtgaccttgaac	7	12	8	14	1	5	2	2	2	3	0	6	2	5	2	2	1	1	1	2	1	1	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr19:5210481C>T	uc002mbv.2	-	35	5720	c.5486G>A	c.(5485-5487)CGG>CAG	p.R1829Q	PTPRS_uc002mbu.1_Missense_Mutation_p.R1398Q|PTPRS_uc010xin.1_Missense_Mutation_p.R1371Q|PTPRS_uc002mbw.2_Missense_Mutation_p.R1791Q|PTPRS_uc002mbx.2_Missense_Mutation_p.R1386Q|PTPRS_uc002mby.2_Missense_Mutation_p.R1382Q	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1829	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TTCACTCACCCGGGCATCTGT	0.557													24	82					0	0	0	0	T	5210481	T	T	5210481	3	4	66	1	0	0	0	0	1	0	0	0	12876	666	23	1	376	1	PTPRS	19	5210481	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08		5210481	53918502	102	13555											
PRAM1	84106	broad.mit.edu	37	chr19	8563261	8563261	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccgcccgccctcacccaccTatggatgctgcagagggtct	6	7	11	17	2	2	1	1	0	1	1	2	2	2	2	5	2	2	2	5	2	1	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr19:8563261T>C	uc002mkd.2	-	2	1451	c.1431A>G	c.(1429-1431)ATA>ATG	p.I477M	PRAM1_uc002mkc.2_Missense_Mutation_p.I477M	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	525							lipid binding|protein binding				0						CTCACCCACCTATGGATGCTG	0.697													6	5					0	0	0	0	C	8563261	C	C	8563261	3	2	66	1	0	0	0	0	1	0	0	0	12483	1536	53	5	614	5	PRAM1	19	8563261	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	3352780	8563261	50565722	103	13556											
OR7A5	26659	broad.mit.edu	37	chr19	14938846	14938846	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggaagtaacacaaatgtCagcaaaggacaggttggaga	16	6	14	5	0	1	1	1	0	0	1	1	4	1	3	0	5	2	3	0	5	4	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr19:14938846C>A	uc002mzw.2	-	1	431	c.208G>T	c.(208-210)GAC>TAC	p.D70Y	OR7A5_uc010xoa.1_Missense_Mutation_p.D70Y	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						ACACAAATGTCAGCAAAGGAC	0.488													39	104					4.32679e-17	5.58296e-17	1	0	A	14938846	A	A	14938846	3	1	66	1	0	0	0	0	1	0	0	0	11270	826	29	2	755	2	OR7A5	19	14938846	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	6375585	14938846	44190137	104	13557											
BRD4	23476	broad.mit.edu	37	chr19	15374344	15374344	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgagcatcacggtactcacGggcctccagtttagactgga	9	9	11	12	2	2	2	2	1	0	1	3	3	3	3	2	3	2	3	2	3	2	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr19:15374344G>A	uc002nar.2	-	7	1450	c.1228C>T	c.(1228-1230)CGT>TGT	p.R410C	BRD4_uc002nas.2_Missense_Mutation_p.R410C|BRD4_uc002nat.3_Missense_Mutation_p.R410C|BRD4_uc002nau.3_Missense_Mutation_p.R410C	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	410	Bromo 2.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			CGGTACTCACGGGCCTCCAGT	0.532			T	NUT|C15orf55	lethal midline carcinoma of young people								17	34					0	0	0	0	A	15374344	A	A	15374344	3	1	66	1	0	0	0	0	1	0	0	0	1509	1116	39	1	2931	1	BRD4	19	15374344	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	435498	15374344	43754639	105	13558											
LILRA1	11024	broad.mit.edu	37	chr19	55107880	55107880	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagcccactcggggacctaCaggtgctacggctcactcag	8	7	11	15	2	3	0	3	0	0	0	4	1	3	1	2	4	4	2	2	4	2	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr19:55107880C>G	uc002qgh.1	+	7	1367	c.1185C>G	c.(1183-1185)TAC>TAG	p.Y395*	LILRA2_uc010yfg.1_Nonsense_Mutation_p.Y393*|LILRA1_uc010yfh.1_Nonsense_Mutation_p.Y395*	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	395	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CGGGGACCTACAGGTGCTACG	0.582													10	210					0	0	0	0	G	55107880	G	G	55107880	4	3	66	1	0	0	0	0	0	1	0	0	8825	489	17	4	1207	4	LILRA1	19	55107880	Nonsense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	39733536	55107880	4021103	106	13559											
DEFB121	245934	broad.mit.edu	37	chr20	29992772	29992772	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctgttaattttggttttaCaggtacatacttgggatcca	9	17	9	6	0	1	0	0	0	1	0	2	1	2	1	1	3	3	3	1	3	4	8			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr20:29992772C>T	uc002wvv.1	-	2	211	c.175G>A	c.(175-177)GTA>ATA	p.V59I		NM_001011878	NP_001011878	Q5J5C9	DB121_HUMAN	defensin, beta 121 precursor	59					defense response to bacterium	extracellular region					0	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TTTGGTTTTACAGGTACATAC	0.413													21	56					0	0	0	0	T	29992772	T	T	29992772	3	4	66	1	0	0	0	0	1	0	0	0	4429	478	17	4	59	4	DEFB121	20	29992772	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08		29992772	33032748	107	13560											
NCOA6	23054	broad.mit.edu	37	chr20	33369945	33369945	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtgtaacaaattgggcaCgtttttcaatattgcatcta	12	15	7	7	1	2	0	1	0	1	0	2	0	2	0	0	1	2	4	0	1	5	7			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr20:33369945C>T	uc002xav.2	-	4	2785	c.214G>A	c.(214-216)GTG>ATG	p.V72M	NCOA6_uc002xaw.2_Missense_Mutation_p.V72M|NCOA6_uc010gew.1_Missense_Mutation_p.V72M	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	72	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						AAATTGGGCACGTTTTTCAAT	0.313													7	25					0	0	0	0	T	33369945	T	T	33369945	3	4	66	1	0	0	0	0	1	0	0	0	10287	536	19	1	6029	1	NCOA6	20	33369945	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08	3377173	33369945	29655575	108	13561											
MYH7B	57644	broad.mit.edu	37	chr20	33587469	33587469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgctggaaggcgagaagagtGagatccaggctgcactggag	11	5	17	8	2	0	3	0	1	0	3	1	7	1	5	1	4	1	3	1	4	2	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr20:33587469G>A	uc002xbi.1	+	35	4854	c.4762G>A	c.(4762-4764)GAG>AAG	p.E1588K		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1546	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CGAGAAGAGTGAGATCCAGGC	0.622													9	41					0	0	0	0	A	33587469	A	A	33587469	3	1	66	1	0	0	0	0	1	0	0	0	10093	1291	45	2	4900	2	MYH7B	20	33587469	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	217524	33587469	29438051	109	13562											
SEMG1	6406	broad.mit.edu	37	chr20	43836893	43836893	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagtatttatagccaaactGaagagaaagcacagggcaag	17	6	11	7	0	0	2	0	1	0	1	0	3	0	2	1	1	3	4	1	1	7	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr20:43836893G>A	uc002xni.2	+	2	1012	c.955G>A	c.(955-957)GAA>AAA	p.E319K	SEMG1_uc002xnj.2_Intron|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.E319K	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	319	58 AA repeat 1.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				TAGCCAAACTGAAGAGAAAGC	0.378													7	32					0	0	0	0	A	43836893	A	A	43836893	3	1	66	1	0	0	0	0	1	0	0	0	14109	1291	45	2	961	2	SEMG1	20	43836893	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	10249424	43836893	19188627	110	13563											
TTC3	7267	broad.mit.edu	37	chr21	38467718	38467718	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatttgatatagctattatCtattacaccagagccattga	14	14	6	7	0	1	4	0	2	1	2	1	4	1	4	2	0	3	1	2	0	6	8			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr21:38467718C>G	uc002yvz.2	+	9	861	c.756C>G	c.(754-756)ATC>ATG	p.I252M	TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Missense_Mutation_p.I252M|TTC3_uc002ywb.2_Missense_Mutation_p.I252M|TTC3_uc010gnf.2_Missense_Mutation_p.I17M|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Missense_Mutation_p.I252M	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	252	TPR 1.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TAGCTATTATCTATTACACCA	0.333													6	73					0	0	0	0	G	38467718	G	G	38467718	3	3	66	1	0	0	0	0	1	0	0	0	16765	903	32	2	786	2	TTC3	21	38467718	Missense_Mutation	SNP	C	TCGA-CN-5370-01A-01D-2012-08		38467718	9662177	111	13564											
TRPM2	7226	broad.mit.edu	37	chr21	45859043	45859044	+	Missense_Mutation	DNP	GG	TT	TT																															ttgaaaacttgctgaagtgcGgcatggaggtattcctggcc																								rs142254503	byFrequency	TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr21:45859043_45859044GG>TT	uc002zet.1	+	31	4474_4475	c.4261_4262GG>TT	c.(4261-4263)GGC>TTC	p.G1421F	TRPM2_uc002zeu.1_Missense_Mutation_p.G1421F|TRPM2_uc002zew.1_Missense_Mutation_p.G1421F|TRPM2_uc010gpt.1_Missense_Mutation_p.G1471F|TRPM2_uc002zex.1_Missense_Mutation_p.G1207F|TRPM2_uc002zey.1_Missense_Mutation_p.G900F|TRPM2_uc011aff.1_Missense_Mutation_p.G102F	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1421	Nudix hydrolase.|Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCTGAAGTGCGGCATGGAGGTA	0.599													7	31					0	0	0	0	TT	45859044	TT	TT	45859043	3	4	66	1	0	0	0	0	1	0	0	0	16653	1116	39	3	4379	3	TRPM2	21	45859043	Missense_Mutation	DNP	GG	TCGA-CN-5370-01A-01D-2012-08	7391325	45859043	2270852	112	13565											
CCDC116	164592	broad.mit.edu	37	chr22	21988525	21988525	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtggagaaggcgactgagcGcatggctgccatgaagacgg	10	5	18	8	3	0	4	0	2	0	2	0	6	0	4	1	5	2	2	1	5	2	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr22:21988525G>T	uc002zve.2	+	3	380	c.287G>T	c.(286-288)CGC>CTC	p.R96L	CCDC116_uc011aih.1_Missense_Mutation_p.R96L	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	96	Potential.									ovary(1)|skin(1)	2	Colorectal(54;0.105)					GCGACTGAGCGCATGGCTGCC	0.632													26	66					4.59853e-10	5.8394e-10	1	0	T	21988525	T	T	21988525	3	4	66	1	0	0	0	0	1	0	0	0	2765	1087	38	3	293	3	CCDC116	22	21988525	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08		21988525	29316041	113	13566											
AP1B1	162	broad.mit.edu	37	chr22	29737728	29737728	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtagatgtagccacggtcccGcaggtctgggttatctgagt	7	11	14	9	2	2	2	0	1	2	1	3	2	3	2	2	3	1	4	2	3	3	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chr22:29737728G>A	uc003afj.2	-	13	1742	c.1558C>T	c.(1558-1560)CGG>TGG	p.R520W	AP1B1_uc003afi.2_Missense_Mutation_p.R520W|AP1B1_uc003afk.2_Missense_Mutation_p.R520W|AP1B1_uc003afl.2_Missense_Mutation_p.R520W|AP1B1_uc011ako.1_Missense_Mutation_p.R73W	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	520					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CCACGGTCCCGCAGGTCTGGG	0.597													20	36					0	0	0	0	A	29737728	A	A	29737728	3	1	66	1	0	0	0	0	1	0	0	0	731	1086	38	1	1335	1	AP1B1	22	29737728	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	7749203	29737728	21566838	114	13567											
FAM47B	170062	broad.mit.edu	37	chrX	34961479	34961479	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacaaccgaggtacccacCgagtctggtaaatatccctg	13	7	9	12	2	1	1	0	0	1	1	2	3	2	1	4	2	2	2	4	2	6	3	rs149160457		TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chrX:34961479C>T	uc004ddi.1	+	1	549	c.531C>T	c.(529-531)ACC>ACT	p.T177T		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	177										ovary(3)|breast(1)	4						AGGTACCCACCGAGTCTGGTA	0.612													11	22					0	0	0	0	T	34961479	T	T	34961479	2	4	66	1	0	0	0	0	0	0	0	1	5602	639	23	1		1	FAM47B	23	34961479	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08		34961479	120309081	115	13568											
MAOA	4128	broad.mit.edu	37	chrX	43601196	43601196	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttccccactgaactgcaGccagtgcattatgaagagaa	12	10	8	11	0	1	3	0	2	1	1	2	4	2	3	3	0	4	2	3	0	4	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chrX:43601196G>C	uc004dfy.2	+	12	1346	c.1165_splice	c.e12-1	p.P389_splice	MAOA_uc011mkw.1_Splice_Site_p.P256_splice	NM_000240	NP_000231	P21397	AOFA_HUMAN	monoamine oxidase A						behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			breast(2)|ovary(1)	3					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	CTGAACTGCAGCCAGTGCATT	0.423													5	17					0	0	0	0	C	43601196	C	C	43601196	5	2	66	1	0	0	0	0	0	0	1	0	9278	985	34	4	1210	4	MAOA	23	43601196	Splice_Site	SNP	G	TCGA-CN-5370-01A-01D-2012-08	8639717	43601196	111669364	116	13569											
PRAF2	11230	broad.mit.edu	37	chrX	48931479	48931479	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccctcacccggcgagagcGaggccgatgccgaagcagag	9	3	14	15	5	1	2	1	0	0	2	2	6	2	2	4	2	3	1	4	2	1	0			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chrX:48931479G>A	uc004dmi.2	-	1	184	c.168C>T	c.(166-168)CTC>CTT	p.L56L	PRAF2_uc004dmh.2_5'Flank|PRAF2_uc011mmt.1_Intron	NM_007213	NP_009144	O60831	PRAF2_HUMAN	PRA1 domain family, member 2	56	Helical; (Potential).				L-glutamate transport|protein transport	endosome membrane|integral to membrane					0						CGGCGAGAGCGAGGCCGATGC	0.647													19	24					0	0	0	0	A	48931479	A	A	48931479	2	1	66	1	0	0	0	0	0	0	0	1	12482	1045	37	1		1	PRAF2	23	48931479	Silent	SNP	G	TCGA-CN-5370-01A-01D-2012-08	5330283	48931479	106339081	117	13570											
GLRA4	441509	broad.mit.edu	37	chrX	102979135	102979135	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccagatagagtccagcatgGagggatcgaggtccagagag	12	6	15	8	1	0	3	0	0	0	3	4	7	3	5	3	3	1	1	3	3	1	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chrX:102979135G>T	uc011mse.1	-	4	786	c.365C>A	c.(364-366)TCC>TAC	p.S122Y	GLRA4_uc010nou.2_Missense_Mutation_p.S122Y	NM_001024452	NP_001019623	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4 precursor	122	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity				0						GTCCAGCATGGAGGGATCGAG	0.527													49	53					1.02067e-35	1.34964e-35	1	0	T	102979135	T	T	102979135	3	4	66	1	0	0	0	0	1	0	0	0	6494	1174	41	2	1007	2	GLRA4	23	102979135	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	54047656	102979135	52291425	118	13571											
IGSF1	3547	broad.mit.edu	37	chrX	130409171	130409171	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caggacaaatgttgagtctgGcagttccccttgacactgaa	11	10	10	10	0	1	3	0	3	1	0	2	4	2	4	2	2	0	3	2	2	2	3			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chrX:130409171G>C	uc004ewd.2	-	17	3512	c.3274C>G	c.(3274-3276)CCA>GCA	p.P1092A	IGSF1_uc004ewe.3_Missense_Mutation_p.P1086A|IGSF1_uc004ewf.2_Missense_Mutation_p.P1072A	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1092	Extracellular (Potential).|Ig-like C2-type 11.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GTTGAGTCTGGCAGTTCCCCT	0.547													7	132					0	0	0	0	C	130409171	C	C	130409171	3	2	66	1	0	0	0	0	1	0	0	0	7635	1203	42	4	752	4	IGSF1	23	130409171	Missense_Mutation	SNP	G	TCGA-CN-5370-01A-01D-2012-08	27430036	130409171	24861389	119	13572											
ARHGAP4	393	broad.mit.edu	37	chrX	153175297	153175297	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcgtgcagccgcagtacgTccccccgccggaagctcagc	6	6	11	18	5	2	0	1	0	1	0	4	1	3	1	5	1	5	4	5	1	2	1			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chrX:153175297T>C	uc004fjk.1	-	19	2354	c.2312A>G	c.(2311-2313)GAC>GGC	p.D771G	ARHGAP4_uc004fjj.1_Missense_Mutation_p.D122G|ARHGAP4_uc011mzf.1_Missense_Mutation_p.D748G|ARHGAP4_uc004fjl.1_Missense_Mutation_p.D811G|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	771	SH3.				apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGCAGTACGTCCCCCCGCCG	0.701													2	3					0	0	0	0	C	153175297	C	C	153175297	3	2	66	1	0	0	0	0	1	0	0	0	885	1667	58	5	544	5	ARHGAP4	23	153175297	Missense_Mutation	SNP	T	TCGA-CN-5370-01A-01D-2012-08	22766126	153175297	2095263	120	13573											
IRAK1	3654	broad.mit.edu	37	chrX	153284101	153284101	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcctcatcaccgcccggtaCacgcacccaaagccaccctc	9	6	5	21	3	2	0	2	0	0	0	4	0	3	0	6	1	2	2	6	1	2	2			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chrX:153284101C>A	uc004fjs.1	-	5	757	c.678G>T	c.(676-678)GTG>GTT	p.V226V	IRAK1_uc004fjr.1_Silent_p.V226V|IRAK1_uc004fjt.1_Silent_p.V226V|IRAK1_uc010nur.2_Intron|IRAK1_uc004fju.2_Silent_p.V252V	NM_001569	NP_001560	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	226	ATP (By similarity).|Protein kinase.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGCCCGGTACACGCACCCAA	0.612													51	70					1.66251e-12	2.12801e-12	1	0	A	153284101	A	A	153284101	2	1	66	1	0	0	0	0	0	0	0	1	7860	465	17	4		4	IRAK1	23	153284101	Silent	SNP	C	TCGA-CN-5370-01A-01D-2012-08	108804	153284101	1986459	121	13574											
EMD	2010	broad.mit.edu	37	chrX	153608360	153608360	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcccaagaaagaggacgcTttactctaccagagcaaggg	13	7	10	11	1	1	3	0	0	1	3	2	4	2	4	2	2	3	2	2	2	5	4			TCGA-CN-5370-01A-01D-2012-08	TCGA-CN-5370-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ca6755-68ca-4702-b08b-65005d31e9be	34dbe31b-1d26-47b3-b6f7-bad6d590e415	g.chrX:153608360T>A	uc004fkl.2	+	3	494	c.246T>A	c.(244-246)GCT>GCA	p.A82A		NM_000117	NP_000108	P50402	EMD_HUMAN	emerin	82	Interaction with F-actin (Probable).				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AAGAGGACGCTTTACTCTACC	0.557													63	78					0	0	0	0	A	153608360	A	A	153608360	2	1	66	1	0	0	0	0	0	0	0	1	5111	1596	56	5		5	EMD	23	153608360	Silent	SNP	T	TCGA-CN-5370-01A-01D-2012-08	324259	153608360	1662200	122	13575											
CD52	1043	broad.mit.edu	37	chr1	26644515	26644515	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagatcctaccaaaatgaagCgcttcctcttcctcctactc	11	11	4	15	1	1	2	0	1	1	1	6	2	5	2	5	0	3	1	5	0	6	4	rs141117966	byFrequency	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:26644515C>T	uc001bmc.2	+	1	105	c.7C>T	c.(7-9)CGC>TGC	p.R3C	UBXN11_uc001bma.2_Intron|CD52_uc009vsg.1_RNA	NM_001803	NP_001794	P31358	CD52_HUMAN	CD52 antigen precursor	3					elevation of cytosolic calcium ion concentration|respiratory burst	anchored to membrane|integral to plasma membrane|membrane fraction					0		all_cancers(24;5.02e-24)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.56e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0137)|READ - Rectum adenocarcinoma(331;0.0649)	Alemtuzumab(DB00087)	CAAAATGAAGCGCTTCCTCTT	0.512													41	109					0	0	0	0	T	26644515	T	T	26644515	3	4	67	1	0	0	0	0	1	0	0	0	3037	768	27	1	9	1	CD52	1	26644515	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08		26644515	222606106	1	13576											
RPS6KA1	6195	broad.mit.edu	37	chr1	26888041	26888041	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctggtgacagagctgatgCggggtggggagctgctggac	7	7	19	8	1	0	3	0	2	0	1	0	5	0	5	1	6	4	3	1	6	0	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:26888041C>T	uc001bmr.1	+	17	1640	c.1477C>T	c.(1477-1479)CGG>TGG	p.R493W	RPS6KA1_uc010ofe.1_Missense_Mutation_p.R401W|RPS6KA1_uc010off.1_Missense_Mutation_p.R477W|RPS6KA1_uc001bms.1_Missense_Mutation_p.R502W|RPS6KA1_uc009vsl.1_Missense_Mutation_p.R336W	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	493	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		AGAGCTGATGCGGGGTGGGGA	0.572													8	211					0	0	0	0	T	26888041	T	T	26888041	3	4	67	1	0	0	0	0	1	0	0	0	13715	759	27	1	1682	1	RPS6KA1	1	26888041	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	243526	26888041	222362580	2	13577											
EIF3I	8668	broad.mit.edu	37	chr1	32694413	32694413	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccctctcccccaactatgAccatgtaagagaaccccacc	11	7	5	18	0	1	2	0	1	1	1	2	3	1	2	7	0	3	1	7	0	4	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:32694413A>G	uc001bur.3	+	9	1258	c.725A>G	c.(724-726)GAC>GGC	p.D242G	EIF3I_uc009vuc.2_Missense_Mutation_p.D242G|EIF3I_uc001bus.2_Missense_Mutation_p.D194G	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	242						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				CCCAACTATGACCATGTAAGA	0.507													96	319					0	0	0	0	G	32694413	G	G	32694413	3	3	67	1	0	0	0	0	1	0	0	0	5043	275	10	5	755	5	EIF3I	1	32694413	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	5806372	32694413	216556208	3	13578											
AK2	204	broad.mit.edu	37	chr1	33480136	33480136	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tacatacgtcatctttcatgGgctcttttggagggttgaac	8	15	10	8	1	4	1	2	1	2	0	4	2	4	2	0	3	3	2	0	3	3	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:33480136G>C	uc001bwp.1	-	5	527	c.485C>G	c.(484-486)CCC>CGC	p.P162R	uc001bwn.2_Intron|AK2_uc001bwo.1_Missense_Mutation_p.P162R|AK2_uc010ohq.1_Missense_Mutation_p.P154R|AK2_uc009vud.1_Missense_Mutation_p.P120R|AK2_uc010ohr.1_Missense_Mutation_p.P114R|AK2_uc001bwq.1_Missense_Mutation_p.P114R	NM_001625	NP_001616	P54819	KAD2_HUMAN	adenylate kinase 2 isoform a	162					nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				ATCTTTCATGGGCTCTTTTGG	0.303													70	398					0	0	0	0	C	33480136	C	C	33480136	3	2	67	1	0	0	0	0	1	0	0	0	440	1232	43	4	251	4	AK2	1	33480136	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	785723	33480136	215770485	4	13579											
TRIM62	55223	broad.mit.edu	37	chr1	33625294	33625294	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgggtggcacttaccgctcGgacagtgaggccaccccagc	7	5	14	15	3	0	1	0	1	0	0	1	2	0	2	4	4	2	2	4	4	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:33625294G>A	uc001bxb.2	-	3	1394	c.756C>T	c.(754-756)TCC>TCT	p.S252S		NM_018207	NP_060677	Q9BVG3	TRI62_HUMAN	tripartite motif-containing 62	252						intracellular	zinc ion binding				0		Myeloproliferative disorder(586;0.0393)				CTTACCGCTCGGACAGTGAGG	0.682													14	31					0	0	0	0	A	33625294	A	A	33625294	2	1	67	1	0	0	0	0	0	0	0	1	16604	1103	39	1		1	TRIM62	1	33625294	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	145158	33625294	215625327	5	13580											
IPO13	9670	broad.mit.edu	37	chr1	44422613	44422613	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatgaggaatatggattctgGtcctcagacgagaaggagca	13	8	14	6	1	2	3	1	1	1	2	3	8	3	6	1	4	1	1	1	4	3	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:44422613G>A	uc001ckx.2	+	5	2031	c.1236G>A	c.(1234-1236)TGG>TGA	p.W412*		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	412	HEAT 6.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				ATGGATTCTGGTCCTCAGACG	0.507													34	90					0	0	0	0	A	44422613	A	A	44422613	4	1	67	1	0	0	0	0	0	1	0	0	7833	1270	44	4	1254	4	IPO13	1	44422613	Nonsense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	10797319	44422613	204828008	6	13581											
C1orf177	163747	broad.mit.edu	37	chr1	55277720	55277720	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacctctgctgtgctctaggGgagtggtctgggacccggca	5	9	15	12	1	3	0	0	0	3	0	3	2	3	2	2	5	2	3	2	5	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:55277720G>A	uc001cyb.3	+	6	674	c.620G>A	c.(619-621)GGG>GAG	p.G207E	C1orf177_uc001cya.3_Missense_Mutation_p.G207E	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	207											0						GTGCTCTAGGGGAGTGGTCTG	0.627													53	164					0	0	0	0	A	55277720	A	A	55277720	3	1	67	1	0	0	0	0	1	0	0	0	2026	1246	43	4	642	4	C1orf177	1	55277720	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	10855107	55277720	193972901	7	13582											
TBX15	6913	broad.mit.edu	37	chr1	119456776	119456776	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgaatcctttagcaaaaggGtttcggtcaatttttaatct	11	16	7	7	1	2	1	1	1	1	0	4	1	3	1	1	2	1	2	1	2	6	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:119456776G>C	uc001ehl.1	-	6	885	c.570C>G	c.(568-570)AAC>AAG	p.N190K		NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	296	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		TAGCAAAAGGGTTTCGGTCAA	0.353													13	88					0	0	0	0	C	119456776	C	C	119456776	3	2	67	1	0	0	0	0	1	0	0	0	15718	1252	44	4	932	4	TBX15	1	119456776	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	64179056	119456776	129793845	8	13583											
ITGA10	8515	broad.mit.edu	37	chr1	145535761	145535761	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccattgtccatctgacccCatcactggaggtgaccccac	8	8	8	17	0	2	2	1	2	1	0	3	3	3	3	6	2	0	0	6	2	0	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:145535761C>T	uc001eoa.2	+	16	2025	c.1949C>T	c.(1948-1950)CCA>CTA	p.P650L	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.P519L|ITGA10_uc009wiw.2_Missense_Mutation_p.P507L|ITGA10_uc010oyw.1_Missense_Mutation_p.P595L	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	650	Extracellular (Potential).|FG-GAP 7.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CATCTGACCCCATCACTGGAG	0.562													7	301					0	0	0	0	T	145535761	T	T	145535761	3	4	67	1	0	0	0	0	1	0	0	0	7912	594	21	4	2011	4	ITGA10	1	145535761	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	26078985	145535761	103714860	9	13584											
FLG	2312	broad.mit.edu	37	chr1	152278060	152278060	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgaccgtattgggatgctGagtgcctggagctgtcttgt	5	13	14	9	1	1	2	0	2	1	0	1	4	1	4	3	2	3	3	3	2	1	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:152278060G>C	uc001ezu.1	-	3	9338	c.9302C>G	c.(9301-9303)TCA>TGA	p.S3101*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3101	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGGGATGCTGAGTGCCTGGA	0.582									Ichthyosis				110	485					0	0	0	0	C	152278060	C	C	152278060	4	2	67	1	0	0	0	0	0	1	0	0	5954	1294	45	2	2887	2	FLG	1	152278060	Nonsense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	6742299	152278060	96972561	10	13585											
PAPPA2	60676	broad.mit.edu	37	chr1	176525520	176525520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctgggtgggcactctgttCtgccaactctgagctgggct	4	11	15	11	0	3	1	0	1	3	0	3	1	3	1	1	4	3	5	1	4	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:176525520C>T	uc001gkz.2	+	2	1226	c.62C>T	c.(61-63)TCT>TTT	p.S21F	PAPPA2_uc001gky.1_Missense_Mutation_p.S21F|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	21					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCACTCTGTTCTGCCAACTCT	0.512													49	170					0	0	0	0	T	176525520	T	T	176525520	3	4	67	1	0	0	0	0	1	0	0	0	11487	913	32	2	64	2	PAPPA2	1	176525520	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	24247460	176525520	72725101	11	13586											
ASTN1	460	broad.mit.edu	37	chr1	176915237	176915237	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagcgtccatccacaccaaGcttgtagtcctcgatgcacc	10	8	8	15	2	0	1	0	0	0	1	4	2	3	1	5	0	3	3	5	0	2	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:176915237G>A	uc001glc.2	-	13	2286	c.2074C>T	c.(2074-2076)CTT>TTT	p.L692F	ASTN1_uc001glb.1_Missense_Mutation_p.L692F|ASTN1_uc001gld.1_Missense_Mutation_p.L692F|ASTN1_uc009wwx.1_Missense_Mutation_p.L692F	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	700	EGF-like 3.				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCCACACCAAGCTTGTAGTCC	0.517													6	116					0	0	0	0	A	176915237	A	A	176915237	3	1	67	1	0	0	0	0	1	0	0	0	1066	971	34	4	1858	4	ASTN1	1	176915237	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	389717	176915237	72335384	12	13587											
EDEM3	80267	broad.mit.edu	37	chr1	184688698	184688698	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatacctcattatggcatcaTagtgctaaaagatcacaaca	16	11	5	9	0	3	1	3	0	0	1	3	1	3	1	1	1	3	2	1	1	7	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:184688698T>C	uc010pok.1	-	10	1217	c.956A>G	c.(955-957)TAT>TGT	p.Y319C	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Missense_Mutation_p.Y319C	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	319				HY -> VS (in Ref. 4; AAI05587).	post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						TATGGCATCATAGTGCTAAAA	0.363													17	78					0	0	0	0	C	184688698	C	C	184688698	3	2	67	1	0	0	0	0	1	0	0	0	4935	1406	49	5	1886	5	EDEM3	1	184688698	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	7773461	184688698	64561923	13	13588											
PTPRC	5788	broad.mit.edu	37	chr1	198703458	198703458	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatttgtttacctcctaggTcccagggatgaaactgttga	9	15	9	8	0	0	2	0	2	0	0	2	3	2	3	3	2	2	2	3	2	4	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:198703458T>C	uc001gur.1	+	22	2355	c.2175T>C	c.(2173-2175)GGT>GGC	p.G725G	PTPRC_uc001gus.1_Silent_p.G677G|PTPRC_uc001gut.1_Silent_p.G564G|PTPRC_uc010ppg.1_Silent_p.G661G	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	725	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ACCTCCTAGGTCCCAGGGATG	0.338													15	725					0	0	0	0	C	198703458	C	C	198703458	2	2	67	1	0	0	0	0	0	0	0	1	12862	1681	58	5		5	PTPRC	1	198703458	Silent	SNP	T	TCGA-CN-5373-01A-01D-1434-08	14014760	198703458	50547163	14	13589											
SLC26A9	115019	broad.mit.edu	37	chr1	205904837	205904837	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagttacctgaaggcattgcGaagtttctctcccactgggt	8	12	10	11	1	1	1	0	1	1	0	3	2	2	1	2	2	2	3	2	2	3	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:205904837G>A	uc001hdq.2	-	2	226	c.112C>T	c.(112-114)CGC>TGC	p.R38C	SLC26A9_uc001hdp.2_Missense_Mutation_p.R38C	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	38						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AAGGCATTGCGAAGTTTCTCT	0.552													50	152					0	0	0	0	A	205904837	A	A	205904837	3	1	67	1	0	0	0	0	1	0	0	0	14588	1058	37	1	2639	1	SLC26A9	1	205904837	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	7201379	205904837	43345784	15	13590											
LYST	1130	broad.mit.edu	37	chr1	235915445	235915445	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttgctgtatatcacaagcaAgcaatttatattcactcatg	13	14	6	8	0	3	0	3	0	0	0	3	0	3	0	0	0	3	5	0	0	7	7			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr1:235915445A>G	uc001hxj.2	-	27	7662	c.7487T>C	c.(7486-7488)CTT>CCT	p.L2496P	LYST_uc009xga.1_Missense_Mutation_p.L78P	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2496					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ATCACAAGCAAGCAATTTATA	0.313									Chediak-Higashi_syndrome				24	69					0	0	0	0	G	235915445	G	G	235915445	3	3	67	1	0	0	0	0	1	0	0	0	9179	72	3	5	4026	5	LYST	1	235915445	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	30010608	235915445	13335176	16	13591											
EML4	27436	broad.mit.edu	37	chr2	42557335	42557335	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaccagcaagacccttcGccctcgtcctaacaccctgg	9	6	9	17	2	0	1	0	0	0	1	3	3	1	2	5	2	2	1	5	2	2	2	rs147316565		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:42557335G>A	uc002rsi.2	+	23	3196	c.2934G>A	c.(2932-2934)TCG>TCA	p.S978S	EML4_uc010fap.2_Silent_p.S920S|EML4_uc002rsj.2_Silent_p.S667S|EML4_uc010faq.2_Silent_p.S323S|EML4_uc010ynv.1_Silent_p.S242S	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	978					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						AAGACCCTTCGCCCTCGTCCT	0.517			T	ALK	NSCLC								18	45					0	0	0	0	A	42557335	A	A	42557335	2	1	67	1	0	0	0	0	0	0	0	1	5123	1074	38	1		1	EML4	2	42557335	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08		42557335	200642038	17	13592											
ASB3	51130	broad.mit.edu	37	chr2	53927532	53927532	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atatatatggttccatggtcCcaatgagcaacctttcctca	11	13	6	11	0	1	1	1	1	0	0	4	1	4	1	4	2	2	2	4	2	5	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:53927532C>G	uc002rxg.1	-	8	1249	c.1114G>C	c.(1114-1116)GGA>CGA	p.G372R	ASB3_uc002rxh.1_Missense_Mutation_p.G299R|ASB3_uc002rxi.3_Missense_Mutation_p.G410R|ASB3_uc002rxf.1_RNA	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	372	ANK 11.				intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TTCCATGGTCCCAATGAGCAA	0.388													26	121					0	0	0	0	G	53927532	G	G	53927532	3	3	67	1	0	0	0	0	1	0	0	0	1026	632	22	4	454	4	ASB3	2	53927532	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	11370197	53927532	189271841	18	13593											
LOXL3	84695	broad.mit.edu	37	chr2	74777400	74777400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtgcgtacagtcactgttcCcccagccccgggaggcacat	7	7	11	16	3	1	0	1	0	0	0	2	1	2	1	4	2	3	3	4	2	1	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:74777400C>T	uc002smp.1	-	3	461	c.389G>A	c.(388-390)GGG>GAG	p.G130E	LOXL3_uc002smo.1_5'Flank|LOXL3_uc010ffm.1_Missense_Mutation_p.G130E|LOXL3_uc002smq.1_Missense_Mutation_p.G130E|LOXL3_uc010ffn.1_Missense_Mutation_p.G130E|DOK1_uc002smr.2_Intron	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	130	SRCR 1.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						GTCACTGTTCCCCCAGCCCCG	0.587													8	148					0	0	0	0	T	74777400	T	T	74777400	3	4	67	1	0	0	0	0	1	0	0	0	8951	623	22	4	1920	4	LOXL3	2	74777400	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	20849868	74777400	168421973	19	13594											
SLC9A2	6549	broad.mit.edu	37	chr2	103324903	103324903	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggctggtctggagggcatcGgaacctggaagccggaaagc	9	5	17	10	3	1	0	0	0	1	0	2	4	1	4	2	7	3	2	2	7	3	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:103324903G>A	uc002tca.2	+	12	2536	c.2394G>A	c.(2392-2394)TCG>TCA	p.S798S		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	798	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						GGAGGGCATCGGAACCTGGAA	0.567													42	97					0	0	0	0	A	103324903	A	A	103324903	2	1	67	1	0	0	0	0	0	0	0	1	14776	1103	39	1		1	SLC9A2	2	103324903	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	28547503	103324903	139874470	20	13595											
LRP1B	53353	broad.mit.edu	37	chr2	142238095	142238095	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcacttgatttctacctcCtcgggacctgaaaagatgta	10	11	10	10	1	1	3	0	2	1	1	3	4	2	4	3	2	1	2	3	2	4	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:142238095C>T	uc002tvj.1	-	3	1185	c.213G>A	c.(211-213)GAG>GAA	p.E71E	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	71	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTCTACCTCCTCGGGACCTG	0.388										TSP Lung(27;0.18)			24	89					0	0	0	0	T	142238095	T	T	142238095	2	4	67	1	0	0	0	0	0	0	0	1	9005	680	24	4		4	LRP1B	2	142238095	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	38913192	142238095	100961278	21	13596											
TTN	7273	broad.mit.edu	37	chr2	179594257	179594257	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcactatattttactaccTccacaggcttcagctctctg	8	14	5	14	1	3	0	2	0	1	0	5	0	4	0	2	1	3	2	2	1	4	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:179594257T>A	uc010zfg.1	-	61	15118	c.14894A>T	c.(14893-14895)GAG>GTG	p.E4965V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E1626V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5892							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTACTACCTCCACAGGCTT	0.468													34	120					0	0	0	0	A	179594257	A	A	179594257	3	1	67	1	0	0	0	0	1	0	0	0	16803	1551	54	5	86099	5	TTN	2	179594257	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	37356162	179594257	63605116	22	13597											
TTN	7273	broad.mit.edu	37	chr2	179606186	179606186	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttttccagagattttgccActgctgattctgtttcagtg	6	17	9	9	0	2	2	1	1	1	1	3	3	3	2	2	0	2	3	2	0	0	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:179606186A>T	uc010zfh.1	-	46	11485	c.11261T>A	c.(11260-11262)GTG>GAG	p.V3754E	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.V3687E|TTN_uc010zfj.1_Missense_Mutation_p.V3562E|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATTTTGCCACTGCTGATTC	0.433													82	230					0	0	0	0	T	179606186	T	T	179606186	3	4	67	1	0	0	0	0	1	0	0	0	16803	159	6	5	93015	5	TTN	2	179606186	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	11929	179606186	63593187	23	13598											
TTN	7273	broad.mit.edu	37	chr2	179612040	179612040	+	Frame_Shift_Del	DEL	G	-	-																															gcaacttcccctaaaggtgtGgaatatctttcaactgtctc																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:179612040delG	uc002unb.2	-	46	15311	c.15087delC	c.(15085-15087)TCCfs	p.S5029fs	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTAAAGGTGTGGAATATCTTT	0.408													---	---	---								-	179612040	-	-	179612040	7	5	67	1	0	1	0	1	0	0	0	0	16803	1335	47	0	95210	0	TTN	2	179612040	Frame_Shift_Del	DEL	G	TCGA-CN-5373-01A-01D-1434-08	5854	179612040	63587333	24	13599											
MDH1B	130752	broad.mit.edu	37	chr2	207611051	207611051	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgggtcattatttgttcaCttatttcaacatctttgaga	9	19	6	7	1	4	1	3	1	1	1	5	2	4	1	0	1	1	1	0	1	3	7			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:207611051C>T	uc002vbs.2	-	8	1371	c.1316G>A	c.(1315-1317)AGT>AAT	p.S439N	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.S439N|MDH1B_uc010fuj.2_Missense_Mutation_p.S341N|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	439					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TATTTGTTCACTTATTTCAAC	0.393													32	74					0	0	0	0	T	207611051	T	T	207611051	3	4	67	1	0	0	0	0	1	0	0	0	9462	565	20	4	260	4	MDH1B	2	207611051	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	27999011	207611051	35588322	25	13600											
PAX3	5077	broad.mit.edu	37	chr2	223163270	223163270	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttccagcgggaacccgctaCgcgggtagttctgccccggg	5	7	14	15	5	1	0	0	0	1	0	2	1	2	1	4	3	4	3	4	3	3	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:223163270C>A	uc010fwo.2	-	1	431	c.65G>T	c.(64-66)CGT>CTT	p.R22L	PAX3_uc002vmt.1_Missense_Mutation_p.R22L|PAX3_uc002vmy.1_Missense_Mutation_p.R22L|PAX3_uc002vmv.1_Missense_Mutation_p.R22L|PAX3_uc002vmw.1_Missense_Mutation_p.R22L|PAX3_uc002vmx.1_Missense_Mutation_p.R22L|PAX3_uc002vmz.1_Missense_Mutation_p.R22L|PAX3_uc002vna.1_Missense_Mutation_p.R22L|CCDC140_uc002vnb.1_Intron	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	22					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAACCCGCTACGCGGGTAGTT	0.701			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						6	18					0.00116845	0.00120815	1	0	A	223163270	A	A	223163270	3	1	67	1	0	0	0	0	1	0	0	0	11534	536	19	3	1621	3	PAX3	2	223163270	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	15552219	223163270	20036103	26	13601											
DOCK10	55619	broad.mit.edu	37	chr2	225670158	225670158	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccgtcttctcactgctcttCtcattggtacttggattgga	5	17	8	11	1	4	0	2	0	4	0	7	2	5	2	1	3	2	2	1	3	1	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr2:225670158C>T	uc010fwz.1	-	35	4142	c.3903G>A	c.(3901-3903)GAG>GAA	p.E1301E	DOCK10_uc002vob.2_Silent_p.E1295E|DOCK10_uc002voa.2_5'UTR|DOCK10_uc002voc.2_Silent_p.E155E	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1301							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CACTGCTCTTCTCATTGGTAC	0.423													16	69					0	0	0	0	T	225670158	T	T	225670158	2	4	67	1	0	0	0	0	0	0	0	1	4707	912	32	2		2	DOCK10	2	225670158	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	2506888	225670158	17529215	27	13602											
CNTN6	27255	broad.mit.edu	37	chr3	1427421	1427421	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actttgcttccgtaagagctTacaacactgctgggacaggg	10	10	11	10	1	0	1	0	0	0	1	1	2	1	2	1	2	5	4	1	2	3	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:1427421T>C	uc003boz.2	+	20	2911	c.2644T>C	c.(2644-2646)TAC>CAC	p.Y882H	CNTN6_uc011asj.1_Missense_Mutation_p.Y810H|CNTN6_uc003bpa.2_Missense_Mutation_p.Y882H	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	882	Fibronectin type-III 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CGTAAGAGCTTACAACACTGC	0.443													69	200					0	0	0	0	C	1427421	C	C	1427421	3	2	67	1	0	0	0	0	1	0	0	0	3660	1754	61	5	2718	5	CNTN6	3	1427421	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08		1427421	196595009	28	13603											
SLC22A14	9389	broad.mit.edu	37	chr3	38357068	38357068	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggaggatggcctcagactCaagtggccacgttgtccggc	7	7	16	11	2	2	1	2	0	0	1	3	3	3	3	3	6	0	1	3	6	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:38357068C>G	uc010hhc.1	+	9	1440	c.1398C>G	c.(1396-1398)CTC>CTG	p.L466L	SLC22A14_uc003cib.2_Silent_p.L466L|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	466	Extracellular (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		GCCTCAGACTCAAGTGGCCAC	0.592													6	89					0	0	0	0	G	38357068	G	G	38357068	2	3	67	1	0	0	0	0	0	0	0	1	14510	813	29	2		2	SLC22A14	3	38357068	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	36929647	38357068	159665362	29	13604											
ZNF445	353274	broad.mit.edu	37	chr3	44491047	44491047	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccccttaggctgagctgcctGcatgttcaggccccatggct	5	10	11	15	0	1	1	1	1	0	0	1	1	1	1	5	3	3	5	5	3	1	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:44491047G>C	uc003cnf.2	-	7	1237	c.889C>G	c.(889-891)CAG>GAG	p.Q297E	ZNF445_uc011azv.1_Missense_Mutation_p.Q285E|ZNF445_uc011azw.1_Missense_Mutation_p.Q297E	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	297	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		TGAGCTGCCTGCATGTTCAGG	0.532													3	89					0	0	0	0	C	44491047	C	C	44491047	3	2	67	1	0	0	0	0	1	0	0	0	17985	1328	46	4	2214	4	ZNF445	3	44491047	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	6133979	44491047	153531383	30	13605											
CADPS	8618	broad.mit.edu	37	chr3	62860609	62860610	+	Frame_Shift_Del	DEL	GC	-	-																															ctggtacggctgggagacagGcgcgcgccggacggggccga																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:62860609_62860610delGC	uc003dll.2	-	1	455_456	c.95_96delGC	c.(94-96)CGCfs	p.R32fs	CADPS_uc003dlm.2_Frame_Shift_Del_p.R32fs|CADPS_uc003dln.2_Frame_Shift_Del_p.R32fs	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	32					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TGGGAGACAGGCGCGCGCCGGA	0.535													---	---	---								-	62860610	-	-	62860609	7	5	67	1	0	1	0	1	0	0	0	0	2582	1190	42	0	4158	0	CADPS	3	62860609	Frame_Shift_Del	DEL	GC	TCGA-CN-5373-01A-01D-1434-08	18369562	62860609	135161821	31	13606											
HTR1F	3355	broad.mit.edu	37	chr3	88039929	88039929	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaaattcatctgatcaaaaCttgacctcagaggaactgtt	14	13	6	8	0	4	3	3	2	1	1	4	4	4	4	1	1	2	1	1	1	5	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:88039929C>G	uc003dqr.2	+	2	188	c.30C>G	c.(28-30)AAC>AAG	p.N10K		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	10	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	CTGATCAAAACTTGACCTCAG	0.373													45	107					0	0	0	0	G	88039929	G	G	88039929	3	3	67	1	0	0	0	0	1	0	0	0	7479	564	20	4	32	4	HTR1F	3	88039929	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	25179320	88039929	109982501	32	13607											
NPHP3	27031	broad.mit.edu	37	chr3	132407968	132407968	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgccccaaggtttcataaaGatcagctaagcaactcatgt	13	10	7	11	1	3	1	3	0	0	1	4	1	3	1	2	1	3	3	2	1	5	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:132407968G>A	uc003epe.1	-	20	2910	c.2833C>T	c.(2833-2835)CTT>TTT	p.L945F	NPHP3_uc003epd.1_Missense_Mutation_p.L187F	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	945	TPR 4.				maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						GTTTCATAAAGATCAGCTAAG	0.448													31	220					0	0	0	0	A	132407968	A	A	132407968	3	1	67	1	0	0	0	0	1	0	0	0	10634	942	33	2	1191	2	NPHP3	3	132407968	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	44368039	132407968	65614462	33	13608											
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	17	7	10	7	0	1	2	1	2	0	0	1	4	1	3	0	3	3	2	0	3	5	0	rs121913279		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			37	77					0	0	0	0	G	178952085	G	G	178952085	3	3	67	1	0	0	0	0	1	0	0	0	11968	217	8	5	3218	5	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	46544117	178952085	19070345	34	13609											
DVL3	1857	broad.mit.edu	37	chr3	183873499	183873499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaagctgcccctgcccgccGagcgcgtcaccttggcggac	5	6	13	17	5	1	1	1	1	0	0	1	3	1	2	5	2	4	1	5	2	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr3:183873499G>A	uc003fms.2	+	1	216	c.76G>A	c.(76-78)GAG>AAG	p.E26K	DVL3_uc011bqw.1_Missense_Mutation_p.E26K|DVL3_uc003fmt.2_5'Flank	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	26	DIX.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CCTGCCCGCCGAGCGCGTCAC	0.547													24	84					0	0	0	0	A	183873499	A	A	183873499	3	1	67	1	0	0	0	0	1	0	0	0	4859	1059	37	1	78	1	DVL3	3	183873499	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	4921414	183873499	14148931	35	13610											
SLIT2	9353	broad.mit.edu	37	chr4	20619158	20619158	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgtgatgaagaggaggaTctgtttaacccatgccaggc	10	10	12	9	0	2	3	0	2	2	1	2	5	2	5	2	3	2	1	2	3	2	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:20619158T>A	uc003gpr.1	+	36	4437	c.4233T>A	c.(4231-4233)GAT>GAA	p.D1411E	SLIT2_uc003gps.1_Missense_Mutation_p.D1403E	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1411					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AAGAGGAGGATCTGTTTAACC	0.552													16	51					0	0	0	0	A	20619158	A	A	20619158	3	1	67	1	0	0	0	0	1	0	0	0	14804	1432	50	5	4375	5	SLIT2	4	20619158	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08		20619158	170535118	36	13611											
KLF3	51274	broad.mit.edu	37	chr4	38691484	38691484	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaactcagtgtcccccccgCaagcattgttgcaagagtaa	11	9	9	12	1	1	2	1	1	0	1	2	2	2	2	3	0	3	5	3	0	4	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:38691484C>T	uc003gth.3	+	4	1011	c.679C>T	c.(679-681)CAA>TAA	p.Q227*	KLF3_uc003gtg.2_Nonsense_Mutation_p.Q227*	NM_016531	NP_057615	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	227	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						GTCCCCCCCGCAAGCATTGTT	0.428													61	205					0	0	0	0	T	38691484	T	T	38691484	4	4	67	1	0	0	0	0	0	1	0	0	8386	711	25	4	689	4	KLF3	4	38691484	Nonsense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	18072326	38691484	152462792	37	13612											
ANKRD17	26057	broad.mit.edu	37	chr4	73990709	73990709	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggcttcaatgtctgcaccaTtgtccagcaatatttccaca	10	12	7	12	0	2	0	1	0	1	0	4	0	4	0	3	1	2	3	3	1	3	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:73990709T>A	uc003hgp.2	-	18	3530	c.3413A>T	c.(3412-3414)AAT>ATT	p.N1138I	ANKRD17_uc003hgo.2_Missense_Mutation_p.N1025I|ANKRD17_uc003hgq.2_Missense_Mutation_p.N887I|ANKRD17_uc003hgr.2_Missense_Mutation_p.N1137I|ANKRD17_uc011cbd.1_Missense_Mutation_p.N703I	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1138	ANK 17.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTCTGCACCATTGTCCAGCAA	0.463													67	172					0	0	0	0	A	73990709	A	A	73990709	3	1	67	1	0	0	0	0	1	0	0	0	646	1493	52	5	4466	5	ANKRD17	4	73990709	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	35299225	73990709	117163567	38	13613											
HSD17B11	51170	broad.mit.edu	37	chr4	88312201	88312201	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtaacgggagaagcaggaGgatgtccagaagaaatttca	16	6	13	6	1	1	3	1	0	0	3	2	6	2	5	1	3	2	2	1	3	4	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:88312201G>A	uc003hqp.2	-	1	255	c.22C>T	c.(22-24)CTC>TTC	p.L8F		NM_016245	NP_057329	Q8NBQ5	DHB11_HUMAN	estradiol 17-beta-dehydrogenase 11	8					androgen catabolic process|steroid biosynthetic process	cytoplasm|extracellular region	binding|estradiol 17-beta-dehydrogenase activity			ovary(2)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000339)		AGAAGCAGGAGGATGTCCAGA	0.443													18	57					0	0	0	0	A	88312201	A	A	88312201	3	1	67	1	0	0	0	0	1	0	0	0	7419	1000	35	4	908	4	HSD17B11	4	88312201	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	14321492	88312201	102842075	39	13614											
AGXT2L1	64850	broad.mit.edu	37	chr4	109667991	109667991	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcactaaatcaattccaaTaaaaaggccaatgcccctgc	15	9	4	13	0	2	0	2	0	0	0	3	0	3	0	4	1	2	0	4	1	8	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:109667991T>A	uc003hzc.2	-	10	1280	c.1099A>T	c.(1099-1101)ATT>TTT	p.I367F	AGXT2L1_uc010imc.2_Missense_Mutation_p.I361F|AGXT2L1_uc011cfm.1_Missense_Mutation_p.I327F|AGXT2L1_uc011cfn.1_Missense_Mutation_p.I294F|AGXT2L1_uc011cfo.1_Missense_Mutation_p.I309F	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	367					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		TCAATTCCAATAAAAAGGCCA	0.448													67	202					0	0	0	0	A	109667991	A	A	109667991	3	1	67	1	0	0	0	0	1	0	0	0	406	1406	49	5	416	5	AGXT2L1	4	109667991	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	21355790	109667991	81486285	40	13615											
SEC24B	10427	broad.mit.edu	37	chr4	110433145	110433145	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataacatcaaataccattgtGaggtgccgatcctgtcgaac	13	10	8	10	2	1	1	1	1	0	0	3	3	2	1	3	1	4	0	3	1	4	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:110433145G>A	uc003hzk.2	+	9	1864	c.1809G>A	c.(1807-1809)GTG>GTA	p.V603V	SEC24B_uc003hzl.2_Silent_p.V568V|SEC24B_uc011cfp.1_Silent_p.V633V|SEC24B_uc011cfq.1_Silent_p.V602V|SEC24B_uc011cfr.1_Silent_p.V567V	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	603					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		ATACCATTGTGAGGTGCCGAT	0.388													40	109					0	0	0	0	A	110433145	A	A	110433145	2	1	67	1	0	0	0	0	0	0	0	1	14060	1277	45	2		2	SEC24B	4	110433145	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	765154	110433145	80721131	41	13616											
CFI	3426	broad.mit.edu	37	chr4	110667591	110667591	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacgtattcaattactatacGtttaaggtcggggtgtatcc	10	14	9	8	3	1	0	1	0	0	0	3	0	2	0	1	3	2	3	1	3	7	8			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:110667591G>A	uc003hzr.3	-	11	1424	c.1216C>T	c.(1216-1218)CGT>TGT	p.R406C	CFI_uc003hzq.2_Missense_Mutation_p.R203C|CFI_uc011cft.1_Missense_Mutation_p.R414C|CFI_uc003hzs.3_Missense_Mutation_p.R399C	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	406	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		ATTACTATACGTTTAAGGTCG	0.333													22	72					0	0	0	0	A	110667591	A	A	110667591	3	1	67	1	0	0	0	0	1	0	0	0	3304	1145	40	1	547	1	CFI	4	110667591	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	234446	110667591	80486685	42	13617											
MAML3	55534	broad.mit.edu	37	chr4	140810676	140810676	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctgctgttgctgttgctgCtgctgttgctgctgctggat	1	17	14	9	0	0	0	0	0	0	0	0	1	0	1	0	1	9	12	0	1	0	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:140810676C>T	uc003ihz.1	-	3	2654	c.1902G>A	c.(1900-1902)CAG>CAA	p.Q634Q	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	634	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					gctgttgctgctgctgttgct	0.423													18	42					0	0	0	0	T	140810676	T	T	140810676	2	4	67	1	0	0	0	0	0	0	0	1	9260	796	28	4		4	MAML3	4	140810676	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	30143085	140810676	50343600	43	13618											
FNIP2	57600	broad.mit.edu	37	chr4	159791528	159791528	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcacttctggcgggctactgCcccacatacatgcctgatct	7	11	8	15	1	3	1	1	1	2	0	3	1	3	1	3	2	4	1	3	2	2	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr4:159791528C>T	uc003iqe.3	+	14	3039	c.2856C>T	c.(2854-2856)TGC>TGT	p.C952C		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	952					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CGGGCTACTGCCCCACATACA	0.522													4	110					0	0	0	0	T	159791528	T	T	159791528	2	4	67	1	0	0	0	0	0	0	0	1	6008	747	26	4		4	FNIP2	4	159791528	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	18980852	159791528	31362748	44	13619											
CDH12	1010	broad.mit.edu	37	chr5	21760760	21760760	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaggtgaaagatctcggtCtgcagcactgactatctgaa	12	9	11	9	1	3	4	0	3	3	1	4	4	3	4	0	2	3	3	0	2	3	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:21760760C>T	uc010iuc.2	-	10	1998	c.1540G>A	c.(1540-1542)GAC>AAC	p.D514N	CDH12_uc011cno.1_Missense_Mutation_p.D474N|CDH12_uc003jgk.2_Missense_Mutation_p.D514N|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	514	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						AGATCTCGGTCTGCAGCACTG	0.403										HNSCC(59;0.17)			62	180					0	0	0	0	T	21760760	T	T	21760760	3	4	67	1	0	0	0	0	1	0	0	0	3113	913	32	2	856	2	CDH12	5	21760760	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08		21760760	159154500	45	13620											
RNASEN	29102	broad.mit.edu	37	chr5	31515178	31515178	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttaagaagttcttcttcttCctcctcattcttgtcaggca	7	17	5	12	0	6	1	2	0	4	1	8	1	8	1	2	1	0	2	2	1	2	7			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:31515178C>T	uc003jhg.2	-	7	1566	c.1207G>A	c.(1207-1209)GAA>AAA	p.E403K	RNASEN_uc003jhh.2_Missense_Mutation_p.E366K|RNASEN_uc003jhi.2_Missense_Mutation_p.E366K|RNASEN_uc010iui.1_Missense_Mutation_p.E326K	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	403					gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						TCTTCTTCTTCCTCCTCATTC	0.468													37	192					0	0	0	0	T	31515178	T	T	31515178	3	4	67	1	0	0	0	0	1	0	0	0	13482	864	30	2	3033	2	RNASEN	5	31515178	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	9754418	31515178	149400082	46	13621											
UGT3A2	167127	broad.mit.edu	37	chr5	36037913	36037913	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatacctcttgtcttccatGatttgtttcatcttaagagc	8	17	6	10	0	4	2	1	1	3	1	5	2	5	2	2	0	2	2	2	0	2	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:36037913G>T	uc003jjz.1	-	6	1374	c.1281C>A	c.(1279-1281)ATC>ATA	p.I427I	UGT3A2_uc011cos.1_Silent_p.I393I|UGT3A2_uc011cot.1_Silent_p.I125I	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	427	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGTCTTCCATGATTTGTTTCA	0.413													61	239					2.02796e-37	2.24977e-37	1	0	T	36037913	T	T	36037913	2	4	67	1	0	0	0	0	0	0	0	1	17032	1280	45	2		2	UGT3A2	5	36037913	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	4522735	36037913	144877347	47	13622											
NIPBL	25836	broad.mit.edu	37	chr5	36986340	36986340	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcagaaacttattaaagatAgagaggacaaatcaagaagt	20	9	8	4	0	2	4	2	0	0	4	2	6	2	5	0	1	1	0	0	1	8	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:36986340A>G	uc003jkl.3	+	10	3557	c.3058A>G	c.(3058-3060)AGA>GGA	p.R1020G	NIPBL_uc003jkk.3_Missense_Mutation_p.R1020G|NIPBL_uc003jkm.1_Missense_Mutation_p.R899G	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1020					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TATTAAAGATAGAGAGGACAA	0.299													53	156					0	0	0	0	G	36986340	G	G	36986340	3	3	67	1	0	0	0	0	1	0	0	0	10482	412	15	5	3092	5	NIPBL	5	36986340	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	948427	36986340	143928920	48	13623											
CMYA5	202333	broad.mit.edu	37	chr5	79031362	79031362	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttagtaaaatctggtgaCggtcaaaacgttaaagaaaa	18	10	8	5	2	2	2	1	1	1	1	2	2	2	2	0	2	1	2	0	2	9	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:79031362C>T	uc003kgc.2	+	2	6846	c.6774C>T	c.(6772-6774)GAC>GAT	p.D2258D		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2258						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AATCTGGTGACGGTCAAAACG	0.338													29	123					0	0	0	0	T	79031362	T	T	79031362	2	4	67	1	0	0	0	0	0	0	0	1	3605	535	19	1		1	CMYA5	5	79031362	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	42045022	79031362	101883898	49	13624											
GPR98	84059	broad.mit.edu	37	chr5	89947506	89947507	+	Frame_Shift_Ins	INS	-	A	A																															gcattttttctctggagcccINSatagacaaagcagtggaaga																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:89947506_89947507insA	uc003kju.2	+	18	3471_3472	c.3375_3376insA	c.(3373-3378)CCCATAfs	p.P1125fs	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1125_1126	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTCTGGAGCCCATAGACAAAGC	0.342													---	---	---								A	89947507	A	A	89947506	7	5	67	1	0	1	1	0	0	0	0	0	6760	581	21	0	3445	0	GPR98	5	89947506	Frame_Shift_Ins	INS	-	TCGA-CN-5373-01A-01D-1434-08	10916144	89947506	90967754	50	13625											
MCTP1	79772	broad.mit.edu	37	chr5	94204039	94204039	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatacagtatgatcataccAcaaaagcagcgagactcctt	16	9	6	10	1	1	2	1	1	0	1	2	3	2	2	2	0	4	2	2	0	6	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:94204039A>G	uc003kkx.2	-	17	2435	c.2435T>C	c.(2434-2436)GTG>GCG	p.V812A	MCTP1_uc003kkv.2_Missense_Mutation_p.V591A|MCTP1_uc003kkw.2_Missense_Mutation_p.V545A|MCTP1_uc003kkz.2_Missense_Mutation_p.V473A|MCTP1_uc003kku.2_Missense_Mutation_p.V328A	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	812	Helical; (Potential).				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TGATCATACCACAAAAGCAGC	0.279													12	47					0	0	0	0	G	94204039	G	G	94204039	3	3	67	1	0	0	0	0	1	0	0	0	9453	173	6	5	592	5	MCTP1	5	94204039	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	4256533	94204039	86711221	51	13626											
FAM81B	153643	broad.mit.edu	37	chr5	94764361	94764361	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attcacttattcaggcaagaGcaccggcaaattgagaaagc	15	8	9	9	1	2	2	2	1	0	2	2	3	2	2	1	2	2	3	1	2	4	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:94764361G>A	uc003kla.1	+	6	757	c.711G>A	c.(709-711)GAG>GAA	p.E237E	FAM81B_uc010jbe.1_Silent_p.E33E	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	237										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		TCAGGCAAGAGCACCGGCAAA	0.408													7	240					0	0	0	0	A	94764361	A	A	94764361	2	1	67	1	0	0	0	0	0	0	0	1	5661	962	34	4		4	FAM81B	5	94764361	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	560322	94764361	86150899	52	13627											
SNX2	6643	broad.mit.edu	37	chr5	122135441	122135441	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagggaacctatcctatcctCggaaccttctcctgcagtca	10	10	7	14	1	2	0	1	0	1	0	6	2	4	2	5	2	3	1	5	2	5	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:122135441C>T	uc003kte.2	+	3	330	c.281C>T	c.(280-282)TCG>TTG	p.S94L	SNX2_uc011cwn.1_5'UTR	NM_003100	NP_003091	O60749	SNX2_HUMAN	sorting nexin 2	94					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			kidney(1)	1		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		ATCCTATCCTCGGAACCTTCT	0.438													60	233					0	0	0	0	T	122135441	T	T	122135441	3	4	67	1	0	0	0	0	1	0	0	0	14955	893	31	1	291	1	SNX2	5	122135441	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	27371080	122135441	58779819	53	13628											
PCDHA8	56140	broad.mit.edu	37	chr5	140222262	140222262	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgacgtgaacgacaatgcTccggcgttcgcgcagcccga	8	5	13	15	8	0	1	0	1	0	0	2	4	1	1	3	1	3	3	3	1	2	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140222262T>C	uc003lhs.2	+	1	1356	c.1356T>C	c.(1354-1356)GCT>GCC	p.A452A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.A452A	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	452	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGACAATGCTCCGGCGTTCG	0.672													37	101					0	0	0	0	C	140222262	C	C	140222262	2	2	67	1	0	0	0	0	0	0	0	1	11584	1538	54	5		5	PCDHA8	5	140222262	Silent	SNP	T	TCGA-CN-5373-01A-01D-1434-08	18086821	140222262	40692998	54	13629											
PCDHA9	9752	broad.mit.edu	37	chr5	140229433	140229433	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggccgacgtgaacgacaaCgcaccagcgttcgcgcagtc	9	5	13	14	7	0	1	0	1	0	0	2	3	0	1	2	1	3	3	2	1	2	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140229433C>T	uc003lhu.2	+	1	2077	c.1353C>T	c.(1351-1353)AAC>AAT	p.N451N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.N451N	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACAACGCACCAGCGT	0.672													6	155					0	0	0	0	T	140229433	T	T	140229433	2	4	67	1	0	0	0	0	0	0	0	1	11585	535	19	1		1	PCDHA9	5	140229433	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	7171	140229433	40685827	55	13630											
PCDHB2	56133	broad.mit.edu	37	chr5	140475977	140475977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttcgagttccgcgtgggcGccgcagaccgcggctccccg	3	6	15	17	9	0	1	0	0	0	1	3	2	2	1	5	2	0	4	5	2	0	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140475977G>A	uc003lil.2	+	1	1741	c.1603G>A	c.(1603-1605)GCC>ACC	p.A535T	PCDHB2_uc003lim.1_Missense_Mutation_p.A196T	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	535	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGCGTGGGCGCCGCAGACCG	0.692													16	90					0	0	0	0	A	140475977	A	A	140475977	3	1	67	1	0	0	0	0	1	0	0	0	11596	1087	38	1	1605	1	PCDHB2	5	140475977	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	246544	140475977	40439283	56	13631											
PCDHB11	56125	broad.mit.edu	37	chr5	140579470	140579470	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggcagaagaaatgcagagCgggagttttgtaggcaatct	12	9	15	5	1	1	3	0	0	1	3	1	4	1	4	0	3	2	5	0	3	4	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140579470C>T	uc003liy.2	+	1	123	c.123C>T	c.(121-123)AGC>AGT	p.S41S	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	41	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATGCAGAGCGGGAGTTTTG	0.522													36	123					0	0	0	0	T	140579470	T	T	140579470	2	4	67	1	0	0	0	0	0	0	0	1	11590	767	27	1		1	PCDHB11	5	140579470	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	103493	140579470	40335790	57	13632											
SLC25A2	83884	broad.mit.edu	37	chr5	140682600	140682610	+	Frame_Shift_Del	DEL	GGGATTGCTCG	-	-																															caaacagtgccccattggcaGggattgctcgaatcatagta																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140682600_140682610delGGGATTGCTCG	uc003ljf.2	-	1	1003_1013	c.823_833delCGAGCAATCCC	c.(823-834)CGAGCAATCCCTfs	p.R275fs		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	275_278	Solcar 3.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	CCCATTGGCAGGGATTGCTCGAATCATAGTA	0.441													---	---	---								-	140682610	-	-	140682600	7	5	67	1	0	1	0	1	0	0	0	0	14546	1000	35	0	76	0	SLC25A2	5	140682600	Frame_Shift_Del	DEL	GGGATTGCTCG	TCGA-CN-5373-01A-01D-1434-08	103130	140682600	40232660	58	13633											
PCDHGA1	56114	broad.mit.edu	37	chr5	140711947	140711947	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcccgagatcctgtaccccGccctccccacagatggttct	6	8	8	19	3	1	2	0	0	1	2	3	3	3	2	7	1	1	2	7	1	1	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140711947G>A	uc003lji.1	+	1	1696	c.1696G>A	c.(1696-1698)GCC>ACC	p.A566T	PCDHGA1_uc011dan.1_Missense_Mutation_p.A566T	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	566	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGTACCCCGCCCTCCCCAC	0.667													78	201					0	0	0	0	A	140711947	A	A	140711947	3	1	67	1	0	0	0	0	1	0	0	0	11604	1087	38	1	1698	1	PCDHGA1	5	140711947	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	29347	140711947	40203313	59	13634											
PCDHGA5	56110	broad.mit.edu	37	chr5	140743969	140743969	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgctcctggggacgctgtgCgagccaggatccgggcagat	7	7	16	11	3	0	1	0	0	0	1	2	4	2	3	3	4	3	3	3	4	0	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140743969C>A	uc003lju.1	+	1	72	c.72C>A	c.(70-72)TGC>TGA	p.C24*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Nonsense_Mutation_p.C24*	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	24					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGCTGTGCGAGCCAGGAT	0.627													13	43					2.27111e-07	2.4067e-07	1	0	A	140743969	A	A	140743969	4	1	67	1	0	0	0	0	0	1	0	0	11611	776	27	3	74	3	PCDHGA5	5	140743969	Nonsense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	32022	140743969	40171291	60	13635											
PCDHGA10	56106	broad.mit.edu	37	chr5	140794626	140794626	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggtgggggagcacacgggCgaggtgcgcacggcgcgagc	6	2	22	11	7	0	0	0	0	0	0	0	3	0	1	0	6	3	2	0	6	0	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:140794626C>T	uc003lkl.1	+	1	1884	c.1884C>T	c.(1882-1884)GGC>GGT	p.G628G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.G628G|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	628	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCACACGGGCGAGGTGCGCA	0.697													28	104					0	0	0	0	T	140794626	T	T	140794626	2	4	67	1	0	0	0	0	0	0	0	1	11605	755	27	1		1	PCDHGA10	5	140794626	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	50657	140794626	40120634	61	13636											
PCDH12	51294	broad.mit.edu	37	chr5	141336333	141336333	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaagagcttctgacaccaGtgatggctgggaggcccatg	9	7	16	9	0	1	3	0	2	1	1	1	5	1	5	2	4	1	2	2	4	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:141336333G>A	uc003llx.2	-	1	2295	c.1084C>T	c.(1084-1086)CTG>TTG	p.L362L		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	362	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGACACCAGTGATGGCTGG	0.502													46	169					0	0	0	0	A	141336333	A	A	141336333	2	1	67	1	0	0	0	0	0	0	0	1	11564	1020	36	4		4	PCDH12	5	141336333	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	541707	141336333	39578927	62	13637											
GEMIN5	25929	broad.mit.edu	37	chr5	154305443	154305443	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtaaccttggacttcacGccttgccaaaaatttttcac	10	13	6	12	1	2	0	2	0	0	0	2	1	2	1	3	1	2	2	3	1	3	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr5:154305443G>T	uc003lvx.3	-	8	1355	c.1272C>A	c.(1270-1272)GGC>GGA	p.G424G	GEMIN5_uc011ddk.1_Silent_p.G423G	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	424	WD 8.				ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGGACTTCACGCCTTGCCAAA	0.373													25	101					1.64293e-13	1.77637e-13	1	0	T	154305443	T	T	154305443	2	4	67	1	0	0	0	0	0	0	0	1	6368	1074	38	3		3	GEMIN5	5	154305443	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	12969110	154305443	26609817	63	13638											
MAS1L	116511	broad.mit.edu	37	chr6	29454873	29454873	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagtaggaacatgggggcCgagatctgcaccaccgcata	12	5	13	11	2	1	2	0	0	1	2	1	4	1	3	3	3	2	3	3	3	3	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:29454873C>T	uc011dlq.1	-	1	807	c.807G>A	c.(805-807)TCG>TCA	p.S269S		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	269	Helical; Name=6; (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						ACATGGGGGCCGAGATCTGCA	0.517													18	60					0	0	0	0	T	29454873	T	T	29454873	2	4	67	1	0	0	0	0	0	0	0	1	9374	639	23	1		1	MAS1L	6	29454873	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08		29454873	141660194	64	13639											
DDR1	780	broad.mit.edu	37	chr6	30865889	30865889	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcagcccagatcgcctcCggcatgcgctatctggccac	6	7	12	16	3	1	1	0	0	1	1	3	1	2	1	4	3	2	3	4	3	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:30865889C>T	uc003nrr.2	+	17	2515	c.2256C>T	c.(2254-2256)TCC>TCT	p.S752S	DDR1_uc010jse.2_Silent_p.S715S|DDR1_uc003nrq.2_Silent_p.S715S|DDR1_uc003nrs.2_Silent_p.S752S|DDR1_uc003nrt.2_Silent_p.S715S|DDR1_uc011dms.1_Silent_p.S733S|DDR1_uc003nru.2_Silent_p.S715S|DDR1_uc003nrv.2_Silent_p.S758S|DDR1_uc003nrw.1_Silent_p.S487S|DDR1_uc003nrz.1_Silent_p.S77S	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	752	Cytoplasmic (Potential).|Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	AGATCGCCTCCGGCATGCGCT	0.562													6	47					0	0	0	0	T	30865889	T	T	30865889	2	4	67	1	0	0	0	0	0	0	0	1	4353	639	23	1		1	DDR1	6	30865889	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	1411016	30865889	140249178	65	13640											
RDBP	7936	broad.mit.edu	37	chr6	31922355	31922355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaaaggaccctctcggtctCggtctcgatcccgctcccga	6	8	11	16	5	3	0	0	0	3	0	8	4	5	2	3	4	0	1	3	4	1	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:31922355C>T	uc003nyk.2	-	7	923	c.719G>A	c.(718-720)CGA>CAA	p.R240Q	RDBP_uc011dot.1_Missense_Mutation_p.R210Q|RDBP_uc003nyl.1_Missense_Mutation_p.R180Q|RDBP_uc003nym.1_Missense_Mutation_p.R235Q	NM_002904	NP_002895	P18615	NELFE_HUMAN	RD RNA-binding protein	240	29.|30 X 2 AA approximate tandem repeats of R-[DSNE].				positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	mitochondrion|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						Ctctcggtctcggtctcgatc	0.224													15	38					0	0	0	0	T	31922355	T	T	31922355	3	4	67	1	0	0	0	0	1	0	0	0	13253	884	31	1	443	1	RDBP	6	31922355	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	1056466	31922355	139192712	66	13641											
EGFL8	80864	broad.mit.edu	37	chr6	32134330	32134330	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgctccactacaacgagtccTacagccaaccagtgtacaag	13	6	7	15	2	0	0	0	0	0	0	2	1	2	0	4	0	6	2	4	0	6	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:32134330T>C	uc003oab.1	+	3	215	c.157T>C	c.(157-159)TAC>CAC	p.Y53H	PPT2_uc003nzy.1_RNA|PPT2_uc010jtu.1_3'UTR|EGFL8_uc003oac.1_Missense_Mutation_p.Y53H	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	53	EMI.					extracellular region|integral to membrane	calcium ion binding				0						CAACGAGTCCTACAGCCAACC	0.592													30	128					0	0	0	0	C	32134330	C	C	32134330	3	2	67	1	0	0	0	0	1	0	0	0	4987	1522	53	5	163	5	EGFL8	6	32134330	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	211975	32134330	138980737	67	13642											
DAXX	1616	broad.mit.edu	37	chr6	33288742	33288742	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttgatgagccgctcaatGcgcctgttaacctctgggta	7	13	11	10	2	2	2	1	2	1	0	2	2	2	2	3	1	3	4	3	1	3	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:33288742G>A	uc003oec.2	-	3	1014	c.810C>T	c.(808-810)CGC>CGT	p.R270R	DAXX_uc011drd.1_Silent_p.R195R|DAXX_uc011dre.1_Silent_p.R282R|DAXX_uc003oed.2_Silent_p.R270R|DAXX_uc010juw.2_Silent_p.R195R	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	270					activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						GCCGCTCAATGCGCCTGTTAA	0.597			Mis|F|N		Pancreatic neuroendocrine tumors								51	121					0	0	0	0	A	33288742	A	A	33288742	2	1	67	1	0	0	0	0	0	0	0	1	4260	1306	46	4		4	DAXX	6	33288742	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	1154412	33288742	137826325	68	13643											
GPRC6A	222545	broad.mit.edu	37	chr6	117127943	117127943	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaatggtggtaatcttggTggcagttgaccaattatcac	11	12	12	6	0	2	1	1	1	1	0	2	2	2	2	1	5	0	3	1	5	4	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:117127943T>C	uc003pxj.1	-	3	947	c.925A>G	c.(925-927)ACC>GCC	p.T309A	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Missense_Mutation_p.T309A	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	309	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		GTAATCTTGGTGGCAGTTGAC	0.348													38	130					0	0	0	0	C	117127943	C	C	117127943	3	2	67	1	0	0	0	0	1	0	0	0	6767	1696	59	5	1871	5	GPRC6A	6	117127943	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	83839201	117127943	53987124	69	13644											
CTGF	1490	broad.mit.edu	37	chr6	132270566	132270567	+	Frame_Shift_Ins	INS	-	T	T																															ccggcagggtggtggttctgINStggggggtgcagcatcggcc																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:132270566_132270567insT	uc003qcz.2	-	5	1093_1094	c.887_888insA	c.(886-888)CACfs	p.H296fs		NM_001901	NP_001892	P29279	CTGF_HUMAN	connective tissue growth factor precursor	296	CTCK.|Heparin-binding.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding				0	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		TGGTGGTTCTGTGGGGGGTGCA	0.53													---	---	---								T	132270567	T	T	132270566	7	5	67	1	0	1	1	0	0	0	0	0	4025	1368	48	0	165	0	CTGF	6	132270566	Frame_Shift_Ins	INS	-	TCGA-CN-5373-01A-01D-1434-08	15142623	132270566	38844501	70	13645											
RPS6KA2	6196	broad.mit.edu	37	chr6	166831722	166831722	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtactcactttagctgcGtcagatatcgagtcccagtt	9	13	8	11	2	2	1	2	0	0	1	4	2	3	1	1	0	3	3	1	0	3	5	rs149521975	byFrequency	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr6:166831722G>A	uc003qvb.1	-	19	2148	c.1929C>T	c.(1927-1929)GAC>GAT	p.D643D	RPS6KA2_uc011ego.1_Silent_p.D554D|RPS6KA2_uc010kkl.1_Silent_p.D554D|RPS6KA2_uc003qvc.1_Silent_p.D651D|RPS6KA2_uc003qvd.1_Silent_p.D668D|RPS6KA2_uc010kkk.1_Silent_p.D75D	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	643	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		CTTTAGCTGCGTCAGATATCG	0.473													42	149					0	0	0	0	A	166831722	A	A	166831722	2	1	67	1	0	0	0	0	0	0	0	1	13716	1136	40	1		1	RPS6KA2	6	166831722	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	34561156	166831722	4283345	71	13646											
THSD7A	221981	broad.mit.edu	37	chr7	11630143	11630143	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttttcgttggcctgcacgCagtacacctctcgggtctgg	4	12	13	12	3	2	0	0	0	2	0	4	0	2	0	2	4	2	5	2	4	1	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:11630143C>T	uc003ssf.3	-	4	1649	c.1397G>A	c.(1396-1398)TGC>TAC	p.C466Y		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	466	Extracellular (Potential).|TSP type-1 4.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GGCCTGCACGCAGTACACCTC	0.532										HNSCC(18;0.044)			19	76					0	0	0	0	T	11630143	T	T	11630143	3	4	67	1	0	0	0	0	1	0	0	0	15945	710	25	4	3672	4	THSD7A	7	11630143	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08		11630143	147508520	72	13647											
CCDC129	223075	broad.mit.edu	37	chr7	31617732	31617732	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtgaaggatgaagtttttgTtccctttacaaaaccatggg	11	13	11	6	0	0	2	0	2	0	0	1	3	1	3	2	3	2	2	2	3	5	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:31617732T>C	uc003tcj.1	+	8	1847	c.854T>C	c.(853-855)GTT>GCT	p.V285A	CCDC129_uc011kad.1_Missense_Mutation_p.V295A|CCDC129_uc003tci.1_Intron|CCDC129_uc011kae.1_Missense_Mutation_p.V311A|CCDC129_uc003tck.1_Missense_Mutation_p.V193A	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	285											0						GAAGTTTTTGTTCCCTTTACA	0.438													15	28					0	0	0	0	C	31617732	C	C	31617732	3	2	67	1	0	0	0	0	1	0	0	0	2776	1725	60	5	880	5	CCDC129	7	31617732	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	19987589	31617732	127520931	73	13648											
ZNF716	441234	broad.mit.edu	37	chr7	57528992	57528992	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacacatgtgaagaacgtggCaaagtctttagccgctcaac	13	9	9	10	2	2	2	1	1	1	1	2	2	2	2	1	1	4	2	1	1	6	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:57528992C>G	uc011kdi.1	+	4	937	c.825C>G	c.(823-825)GGC>GGG	p.G275G		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						AAGAACGTGGCAAAGTCTTTA	0.423													13	39					0	0	0	0	G	57528992	G	G	57528992	2	3	67	1	0	0	0	0	0	0	0	1	18186	697	25	4		4	ZNF716	7	57528992	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	25911260	57528992	101609671	74	13649											
ALKBH4	54784	broad.mit.edu	37	chr7	102097843	102097843	+	Nonstop_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagccaaggaggcggttcAcacgggtcttccctggaagg	8	7	16	10	2	2	0	1	0	1	0	3	3	3	3	2	7	1	1	2	7	2	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:102097843A>T	uc003uzl.2	-	3	912	c.907T>A	c.(907-909)TGA>AGA	p.*303R	ALKBH4_uc003uzm.2_Nonstop_Mutation_p.*230R	NM_017621	NP_060091	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4	303						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GAGGCGGTTCACACGGGTCTT	0.602													20	95					0	0	0	0	T	102097843	T	T	102097843	4	4	67	1	0	0	0	0	0	0	0	0	529	172	6	5	5	5	ALKBH4	7	102097843	Nonstop_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	44568851	102097843	57040820	75	13650											
TAS2R41	259287	broad.mit.edu	37	chr7	143175526	143175526	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcccatccctgaaactggtCatctggtcaattcctttttc	7	16	5	13	0	3	1	2	1	1	0	7	1	6	1	3	2	1	0	3	2	2	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr7:143175526C>A	uc003wdc.1	+	1	561	c.561C>A	c.(559-561)GTC>GTA	p.V187V	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	187	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					TGAAACTGGTCATCTGGTCAA	0.378													20	93					5.03518e-11	5.41664e-11	1	0	A	143175526	A	A	143175526	2	1	67	1	0	0	0	0	0	0	0	1	15645	813	29	2		2	TAS2R41	7	143175526	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	41077683	143175526	15963137	76	13651											
DCAF4L2	138009	broad.mit.edu	37	chr8	88886033	88886033	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgaatctggacctttttcCtctgcatgcagcttacacgc	8	14	7	12	1	2	1	0	1	2	0	3	2	3	2	2	1	4	3	2	1	3	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:88886033C>A	uc003ydz.2	-	1	264	c.167G>T	c.(166-168)AGG>ATG	p.R56M		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	56										ovary(1)	1						GACCTTTTTCCTCTGCATGCA	0.507													70	99					1.26778e-28	1.39194e-28	1	0	A	88886033	A	A	88886033	3	1	67	1	0	0	0	0	1	0	0	0	4289	681	24	4	1024	4	DCAF4L2	8	88886033	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08		88886033	57477989	77	13652											
RGS22	26166	broad.mit.edu	37	chr8	101020655	101020655	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctttgtccatggctcaagaAggaggagaaggatatattcc	12	11	11	7	0	2	2	1	0	1	2	4	5	4	4	2	4	0	1	2	4	5	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:101020655A>G	uc003yjb.1	-	15	2504	c.2309T>C	c.(2308-2310)CTT>CCT	p.L770P	RGS22_uc003yja.1_Missense_Mutation_p.L589P|RGS22_uc003yjc.1_Missense_Mutation_p.L758P|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	770	Poly-Leu.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGGCTCAAGAAGGAGGAGAAG	0.378													6	230					0	0	0	0	G	101020655	G	G	101020655	3	3	67	1	0	0	0	0	1	0	0	0	13370	72	3	5	1537	5	RGS22	8	101020655	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	12134622	101020655	45343367	78	13653											
RIMS2	9699	broad.mit.edu	37	chr8	105160892	105160892	+	Frame_Shift_Del	DEL	A	-	-																															atatcagggaagaacatgacAaaaagcaccagcatcagtgg																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:105160892delA	uc003yls.2	+	23	3445	c.3204delA	c.(3202-3204)ACAfs	p.T1068fs	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Frame_Shift_Del_p.T1057fs|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGAACATGACAAAAAGCACCA	0.468										HNSCC(12;0.0054)			---	---	---								-	105160892	-	-	105160892	7	5	67	1	0	1	0	1	0	0	0	0	13433	145	5	0		0	RIMS2	8	105160892	Frame_Shift_Del	DEL	A	TCGA-CN-5373-01A-01D-1434-08	4140237	105160892	41203130	79	13654											
RSPO2	340419	broad.mit.edu	37	chr8	109001434	109001434	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccattgtcctttgaacaagAcaaacaacccttgcaaatgg	14	9	6	12	0	0	2	0	1	0	1	1	2	1	2	3	1	4	1	3	1	5	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:109001434A>G	uc003yms.2	-	3	791	c.133T>C	c.(133-135)TCT>CCT	p.S45P	RSPO2_uc003ymq.2_5'UTR|RSPO2_uc003ymr.2_Intron	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	45					Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			TTTGAACAAGACAAACAACCC	0.378													19	92					0	0	0	0	G	109001434	G	G	109001434	3	3	67	1	0	0	0	0	1	0	0	0	13775	275	10	5	614	5	RSPO2	8	109001434	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	3840542	109001434	37362588	80	13655											
PKHD1L1	93035	broad.mit.edu	37	chr8	110439257	110439257	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgctgctgtgtcagctgcaGatctgcagtttgcactccag	6	11	11	13	1	2	1	1	0	1	1	3	1	3	1	2	0	5	7	2	0	0	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:110439257G>A	uc003yne.2	+	25	2976	c.2872G>A	c.(2872-2874)GAT>AAT	p.D958N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	958	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTCAGCTGCAGATCTGCAGTT	0.478										HNSCC(38;0.096)			35	194					0	0	0	0	A	110439257	A	A	110439257	3	1	67	1	0	0	0	0	1	0	0	0	12027	942	33	2	2970	2	PKHD1L1	8	110439257	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	1437823	110439257	35924765	81	13656											
TG	7038	broad.mit.edu	37	chr8	134042151	134042151	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccacatccgaggatttggCggggaccctcggcgcgtgtc	6	7	14	14	5	0	0	0	0	0	0	3	3	1	2	3	5	0	0	3	5	0	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:134042151C>T	uc003ytw.2	+	41	7163	c.7122C>T	c.(7120-7122)GGC>GGT	p.G2374G	TG_uc010mdw.2_Silent_p.G1133G|TG_uc011ljb.1_Silent_p.G743G|TG_uc011ljc.1_Silent_p.G507G	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2374					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GAGGATTTGGCGGGGACCCTC	0.652													17	40					0	0	0	0	T	134042151	T	T	134042151	2	4	67	1	0	0	0	0	0	0	0	1	15879	755	27	1		1	TG	8	134042151	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	23602894	134042151	12321871	82	13657											
TG	7038	broad.mit.edu	37	chr8	134144071	134144071	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcagcctggagctgctggcGgatgttcagtttgccttggg	4	12	15	10	1	2	0	2	0	0	0	2	2	2	2	2	4	4	4	2	4	0	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr8:134144071G>A	uc003ytw.2	+	46	7919	c.7878G>A	c.(7876-7878)GCG>GCA	p.A2626A	TG_uc010mdw.2_Silent_p.A1385A|TG_uc011ljb.1_Silent_p.A995A|TG_uc011ljc.1_Silent_p.A759A	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2626					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCTGCTGGCGGATGTTCAGT	0.458													29	95					0	0	0	0	A	134144071	A	A	134144071	2	1	67	1	0	0	0	0	0	0	0	1	15879	1103	39	1		1	TG	8	134144071	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	101920	134144071	12219951	83	13658											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			7	9					0	0	0	0	A	21971120	A	A	21971120	4	1	67	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08		21971120	119242311	84	13659											
FGD3	89846	broad.mit.edu	37	chr9	95765216	95765216	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctctccgcagcactctggcCcccagaagcttctccacatt	7	10	6	18	1	3	1	0	0	3	1	6	1	4	1	4	1	2	3	4	1	1	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:95765216C>G	uc004asw.2	+	4	1091	c.463C>G	c.(463-465)CCC>GCC	p.P155A	FGD3_uc004asx.2_Missense_Mutation_p.P155A|FGD3_uc004asz.2_Missense_Mutation_p.P155A|FGD3_uc004ata.2_5'UTR	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	155					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						GCACTCTGGCCCCCAGAAGCT	0.617													44	306					0	0	0	0	G	95765216	G	G	95765216	3	3	67	1	0	0	0	0	1	0	0	0	5866	623	22	4	469	4	FGD3	9	95765216	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	73794096	95765216	45448215	85	13660											
SNX30	401548	broad.mit.edu	37	chr9	115598545	115598545	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgctgaccagaatgggcGagtcagtcaagcacgtcact	11	8	11	11	2	3	2	3	1	0	1	3	3	3	2	1	1	2	2	1	1	2	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:115598545G>T	uc004bgj.3	+	5	818	c.670G>T	c.(670-672)GAG>TAG	p.E224*	SNX30_uc004bgi.3_5'Flank	NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	224					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						CAGAATGGGCGAGTCAGTCAA	0.507													56	194					5.82089e-37	6.42409e-37	1	0	T	115598545	T	T	115598545	4	4	67	1	0	0	0	0	0	1	0	0	14964	1059	37	3	688	3	SNX30	9	115598545	Nonsense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	19833329	115598545	25614886	86	13661											
BSPRY	54836	broad.mit.edu	37	chr9	116116596	116116596	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatgtggcggacgtcctgcCggggaagaatcaaagagcag	11	6	16	8	3	1	2	1	0	0	2	2	4	2	4	2	4	2	2	2	4	4	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:116116596C>A	uc004bhg.3	+	2	326	c.278C>A	c.(277-279)CCG>CAG	p.P93Q	BSPRY_uc010muw.2_Missense_Mutation_p.P93Q	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	93					calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						GACGTCCTGCCGGGGAAGAAT	0.478													14	57					0.000151284	0.000157959	1	0	A	116116596	A	A	116116596	3	1	67	1	0	0	0	0	1	0	0	0	1537	652	23	3	284	3	BSPRY	9	116116596	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	518051	116116596	25096835	87	13662											
LHX3	8022	broad.mit.edu	37	chr9	139090820	139090820	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcacgtggcgcgccggcttGggcgaggtgttgtaagcgct	4	8	18	11	7	0	0	0	0	0	0	0	1	0	0	1	4	1	5	1	4	1	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr9:139090820G>A	uc004cha.2	-	4	637	c.540C>T	c.(538-540)CCC>CCT	p.P180P	LHX3_uc004cgz.2_Silent_p.P185P	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	180	Homeobox.				inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		GCGCCGGCTTGGGCGAGGTGT	0.731													8	23					0	0	0	0	A	139090820	A	A	139090820	2	1	67	1	0	0	0	0	0	0	0	1	8813	1335	47	4		4	LHX3	9	139090820	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	22974224	139090820	2122611	88	13663											
DDX21	9188	broad.mit.edu	37	chr10	70741337	70741337	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcatcagtaacagaaatacaGgtattcttttcccttagatt	13	14	6	8	0	2	2	1	0	1	2	3	2	3	2	1	1	2	3	1	1	5	8			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr10:70741337G>A	uc001jov.1	+	14	2172	c.2082G>A	c.(2080-2082)CAG>CAA	p.Q694Q	DDX21_uc001jow.1_Silent_p.Q626Q	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	694						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						CAGAAATACAGGTATTCTTTT	0.328													4	130					0	0	0	0	A	70741337	A	A	70741337	2	1	67	1	0	0	0	0	0	0	0	1	4366	1014	35	4		4	DDX21	10	70741337	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08		70741337	64793410	89	13664											
RBMXL2	27288	broad.mit.edu	37	chr11	7110534	7110534	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctttgaaagccccgcagaCgccaaggccgccgccagaga	11	3	11	16	4	0	3	0	1	0	2	0	4	0	3	7	1	1	1	7	1	2	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:7110534C>T	uc001mfc.2	+	1	370	c.183C>T	c.(181-183)GAC>GAT	p.D61D		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	61	RRM.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCCCCGCAGACGCCAAGGCCG	0.617													4	28					0	0	0	0	T	7110534	T	T	7110534	2	4	67	1	0	0	0	0	0	0	0	1	13219	535	19	1		1	RBMXL2	11	7110534	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08		7110534	127895982	90	13665											
PAMR1	25891	broad.mit.edu	37	chr11	35513609	35513609	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttacgcatgcagtctcctccGtaccagcctgctcggcactc	6	10	8	17	3	1	0	0	0	1	0	5	0	2	0	4	1	5	5	4	1	2	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:35513609G>A	uc001mwg.2	-	3	406	c.363C>T	c.(361-363)TAC>TAT	p.Y121Y	PAMR1_uc001mwf.2_Silent_p.Y121Y|PAMR1_uc010rew.1_Silent_p.Y121Y|PAMR1_uc010rex.1_Silent_p.Y81Y	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	121					proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						AGTCTCCTCCGTACCAGCCTG	0.493													57	191					0	0	0	0	A	35513609	A	A	35513609	2	1	67	1	0	0	0	0	0	0	0	1	11467	1140	40	1		1	PAMR1	11	35513609	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	28403075	35513609	99492907	91	13666											
OR5A2	219981	broad.mit.edu	37	chr11	59189802	59189802	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaccactagcacagacactaTtccaacgacaacactgacta	16	6	5	14	1	0	2	0	1	0	1	1	4	1	2	2	0	3	1	2	0	5	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:59189802T>C	uc010rkt.1	-	1	625	c.625A>G	c.(625-627)ATA>GTA	p.I209V		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACAGACACTATTCCAACGACA	0.498													14	75					0	0	0	0	C	59189802	C	C	59189802	3	2	67	1	0	0	0	0	1	0	0	0	11194	1493	52	5	351	5	OR5A2	11	59189802	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	23676193	59189802	75816714	92	13667											
ATL3	25923	broad.mit.edu	37	chr11	63403702	63403702	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaaatactccagtagtccccGacaggtgacctttgagccat	12	9	8	12	1	0	2	0	2	0	0	2	3	2	2	5	1	2	1	5	1	4	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:63403702G>A	uc001nxk.1	-	9	1231	c.955C>T	c.(955-957)CGG>TGG	p.R319W	ATL3_uc010rms.1_Missense_Mutation_p.R301W|ATL3_uc010rmr.1_5'Flank	NM_015459	NP_056274	Q6DD88	ATLA3_HUMAN	atlastin 3	319	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			pancreas(1)	1						AGTAGTCCCCGACAGGTGACC	0.358											OREG0021036	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	186					0	0	0	0	A	63403702	A	A	63403702	3	1	67	1	0	0	0	0	1	0	0	0	1110	1057	37	1	690	1	ATL3	11	63403702	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	4213900	63403702	71602814	93	13668											
NAALADL1	10004	broad.mit.edu	37	chr11	64825682	64825682	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagctgcaccaggtcctcatCccgagggctggaggccaggt	7	6	14	14	1	1	0	1	0	0	0	3	2	3	1	4	5	2	3	4	5	0	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:64825682C>T	uc001ocn.2	-	2	242	c.226G>A	c.(226-228)GAT>AAT	p.D76N	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	76	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						AGGTCCTCATCCCGAGGGCTG	0.677													14	42					0	0	0	0	T	64825682	T	T	64825682	3	4	67	1	0	0	0	0	1	0	0	0	10182	855	30	2	2064	2	NAALADL1	11	64825682	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	1421980	64825682	70180834	94	13669											
NPAS4	266743	broad.mit.edu	37	chr11	66190251	66190251	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccatgctcacccacctggAgcctactgggcaggaaatcc	9	8	9	15	0	1	0	1	0	0	0	3	2	3	2	5	3	3	2	5	3	2	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:66190251A>T	uc001ohx.1	+	4	713	c.537A>T	c.(535-537)GGA>GGT	p.G179G	NPAS4_uc010rpc.1_Missense_Mutation_p.E6V	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	179					transcription, DNA-dependent		DNA binding|signal transducer activity				0						ACCCACCTGGAGCCTACTGGG	0.632													44	181					0	0	0	0	T	66190251	T	T	66190251	2	4	67	1	0	0	0	0	0	0	0	1	10619	291	11	5		5	NPAS4	11	66190251	Silent	SNP	A	TCGA-CN-5373-01A-01D-1434-08	1364569	66190251	68816265	95	13670											
DLG2	1740	broad.mit.edu	37	chr11	84245683	84245683	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgagagaggttcttttctGatacatgcacgagttctggg	8	15	12	6	1	3	3	0	2	3	1	3	5	3	3	0	2	2	3	0	2	1	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:84245683G>A	uc001paj.2	-	2	437	c.134C>T	c.(133-135)TCA>TTA	p.S45L	DLG2_uc010rsz.1_Missense_Mutation_p.S45L|DLG2_uc010rta.1_Missense_Mutation_p.S45L|DLG2_uc001pak.2_Missense_Mutation_p.S150L|DLG2_uc001pal.1_Missense_Mutation_p.S45L	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	45						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GTTCTTTTCTGATACATGCAC	0.418													44	245					0	0	0	0	A	84245683	A	A	84245683	3	1	67	1	0	0	0	0	1	0	0	0	4577	1294	45	2	2725	2	DLG2	11	84245683	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	18055432	84245683	50760833	96	13671											
FAT3	120114	broad.mit.edu	37	chr11	92534195	92534195	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaaccagctgaaaaatacAgtgctttcgttctttgtcaa	12	15	6	8	1	2	1	1	1	1	0	3	1	2	1	1	0	4	3	1	0	5	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:92534195A>G	uc001pdj.3	+	9	8033	c.8016A>G	c.(8014-8016)ACA>ACG	p.T2672T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2672	Cadherin 24.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAAAAATACAGTGCTTTCGT	0.483										TCGA Ovarian(4;0.039)			6	43					0	0	0	0	G	92534195	G	G	92534195	2	3	67	1	0	0	0	0	0	0	0	1	5723	175	7	5		5	FAT3	11	92534195	Silent	SNP	A	TCGA-CN-5373-01A-01D-1434-08	8288512	92534195	42472321	97	13672											
KDM4D	55693	broad.mit.edu	37	chr11	94731017	94731017	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgggcacctgggaacaattCaggacctgctggaaaaggaa	13	7	13	8	0	1	0	1	0	0	0	1	4	1	4	2	5	2	2	2	5	5	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:94731017C>T	uc001pfe.2	+	3	1313	c.481C>T	c.(481-483)CAG>TAG	p.Q161*		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	161	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GGGAACAATTCAGGACCTGCT	0.448													32	93					0	0	0	0	T	94731017	T	T	94731017	4	4	67	1	0	0	0	0	0	1	0	0	8170	827	29	2	483	2	KDM4D	11	94731017	Nonsense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	2196822	94731017	40275499	98	13673											
ATM	472	broad.mit.edu	37	chr11	108143452	108143452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttcttttcccgtaggctGatccttattcaaaatgggcc	8	14	8	11	1	2	1	1	1	1	0	4	1	4	1	3	2	0	3	3	2	4	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:108143452G>A	uc001pkb.1	+	22	3542	c.3157G>A	c.(3157-3159)GAT>AAT	p.D1053N	ATM_uc009yxr.1_Missense_Mutation_p.D1053N	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1053					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CCCGTAGGCTGATCCTTATTC	0.318			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			21	78					0	0	0	0	A	108143452	A	A	108143452	3	1	67	1	0	0	0	0	1	0	0	0	1111	1290	45	2	3239	2	ATM	11	108143452	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	13412435	108143452	26863064	99	13674											
DSCAML1	57453	broad.mit.edu	37	chr11	117302401	117302401	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cactggcttgagtaccggttCcgggtgctgtgggctgactt	4	12	15	10	2	0	2	0	2	0	0	1	2	1	2	2	4	2	5	2	4	1	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr11:117302401C>T	uc001prh.1	-	31	5405	c.5403G>A	c.(5401-5403)CGG>CGA	p.R1801R		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1741	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGTACCGGTTCCGGGTGCTGT	0.612													48	130					0	0	0	0	T	117302401	T	T	117302401	2	4	67	1	0	0	0	0	0	0	0	1	4791	842	30	2		2	DSCAML1	11	117302401	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	9158949	117302401	17704115	100	13675											
KCNA1	3736	broad.mit.edu	37	chr12	5021875	5021875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgacagtgacctcagtcgccGcagttcctctactatgagca	9	10	9	13	2	2	3	1	3	1	0	4	3	3	3	3	0	2	3	3	0	2	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:5021875G>A	uc001qnh.2	+	2	2436	c.1331G>A	c.(1330-1332)CGC>CAC	p.R444H		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	444					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTCAGTCGCCGCAGTTCCTCT	0.468													80	320					0	0	0	0	A	5021875	A	A	5021875	3	1	67	1	0	0	0	0	1	0	0	0	8040	1087	38	1	1333	1	KCNA1	12	5021875	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08		5021875	128830020	101	13676											
VWF	7450	broad.mit.edu	37	chr12	6173440	6173440	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agggggagctggacgtcctgGccatccatggcaactcctgc	7	7	14	13	1	0	0	0	0	0	0	3	2	3	2	4	5	3	2	4	5	1	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:6173440G>A	uc001qnn.1	-	12	1654	c.1404C>T	c.(1402-1404)GGC>GGT	p.G468G	VWF_uc010set.1_Silent_p.G468G	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	468	VWFD 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GGACGTCCTGGCCATCCATGG	0.632													17	70					0	0	0	0	A	6173440	A	A	6173440	2	1	67	1	0	0	0	0	0	0	0	1	17314	1190	42	4		4	VWF	12	6173440	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	1151565	6173440	127678455	102	13677											
CD27	939	broad.mit.edu	37	chr12	6554350	6554350	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccaagagctgcccagagaGgcactactgggctcagggaa	11	4	13	13	0	1	2	1	0	0	2	1	4	1	3	3	3	3	3	3	3	3	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:6554350G>A	uc001qod.2	+	1	300	c.89G>A	c.(88-90)AGG>AAG	p.R30K	LOC678655_uc001qob.2_Intron|LOC678655_uc001qoc.2_Intron|LOC678655_uc009zel.1_Intron|CD27_uc001qoe.2_5'Flank	NM_001242	NP_001233	P26842	CD27_HUMAN	tumor necrosis factor receptor superfamily,	30	Extracellular (Potential).|TNFR-Cys 1.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity				0						TGCCCAGAGAGGCACTACTGG	0.637													11	35					0	0	0	0	A	6554350	A	A	6554350	3	1	67	1	0	0	0	0	1	0	0	0	3005	1000	35	4	91	4	CD27	12	6554350	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	380910	6554350	127297545	103	13678											
LEPREL2	10536	broad.mit.edu	37	chr12	6939120	6939120	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggacatggctaagtacagacGaatgtcgggagttcggcccc	10	7	14	10	3	0	1	0	0	0	1	2	4	0	3	2	4	1	3	2	4	3	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:6939120G>A	uc001qra.1	+	4	630	c.596G>A	c.(595-597)CGA>CAA	p.R199Q	LEPREL2_uc001qqz.1_Missense_Mutation_p.R6Q|LEPREL2_uc001qrb.1_Missense_Mutation_p.R6Q|GPR162_uc001qqy.1_Missense_Mutation_p.R134Q	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	199					negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AAGTACAGACGAATGTCGGGA	0.592													40	149					0	0	0	0	A	6939120	A	A	6939120	3	1	67	1	0	0	0	0	1	0	0	0	8771	1058	37	1	601	1	LEPREL2	12	6939120	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	384770	6939120	126912775	104	13679											
GNB3	2784	broad.mit.edu	37	chr12	6952179	6952179	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgagtccagatgcggacgCggcggacgttaaggggacac	10	4	17	10	6	0	1	0	0	0	1	1	6	1	4	1	5	1	1	1	5	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:6952179C>T	uc001qrd.2	+	5	547	c.142C>T	c.(142-144)CGG>TGG	p.R48W	GNB3_uc001qrc.2_Missense_Mutation_p.R4W|GNB3_uc009zfe.2_Missense_Mutation_p.R48W	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	48					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						GATGCGGACGCGGCGGACGTT	0.597													5	72					0	0	0	0	T	6952179	T	T	6952179	3	4	67	1	0	0	0	0	1	0	0	0	6556	759	27	1	152	1	GNB3	12	6952179	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	13059	6952179	126899716	105	13680											
BICD1	636	broad.mit.edu	37	chr12	32446959	32446959	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtggagctacagagaatacGgatgaaggatgaaatccgag	15	6	15	5	2	0	3	0	2	0	1	1	8	1	6	1	4	3	1	1	4	5	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:32446959G>A	uc001rku.2	+	3	539	c.458G>A	c.(457-459)CGG>CAG	p.R153Q	BICD1_uc001rkv.2_Missense_Mutation_p.R153Q|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	153	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CAGAGAATACGGATGAAGGAT	0.388													3	56					0	0	0	0	A	32446959	A	A	32446959	3	1	67	1	0	0	0	0	1	0	0	0	1431	1116	39	1	468	1	BICD1	12	32446959	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	25494780	32446959	101404936	106	13681											
KRT5	3852	broad.mit.edu	37	chr12	52913851	52913852	+	Frame_Shift_Ins	INS	-	ATCAA	ATCAA																															gaagctgccaccactagtgcINStgatggatatcctcttggag																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:52913851_52913852insATCAA	uc001san.2	-	1	392_393	c.229_230insTTGAT	c.(229-231)AGCfs	p.S77fs	KRT5_uc009zmh.2_Frame_Shift_Ins_p.S77fs	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	77	Head.|Gly-rich.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACCACTAGTGCTGATGGATATC	0.401													---	---	---								ATCAA	52913852	ATCAA	ATCAA	52913851	7	5	67	1	0	1	1	0	0	0	0	0	8518	797	28	0	1578	0	KRT5	12	52913851	Frame_Shift_Ins	INS	-	TCGA-CN-5373-01A-01D-1434-08	20466892	52913851	80938044	107	13682											
KRT5	3852	broad.mit.edu	37	chr12	52913991	52913992	+	Frame_Shift_Ins	INS	-	GT	GT																															gggacacggaggtgaagctgINSgtgcgggagacagacggggt																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:52913991_52913992insGT	uc001san.2	-	1	252_253	c.89_90insAC	c.(88-90)ACCfs	p.T30fs	KRT5_uc009zmh.2_Frame_Shift_Ins_p.T30fs	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	30	Head.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGGTGAAGCTGGTGCGGGAGAC	0.663													---	---	---								GT	52913992	GT	GT	52913991	7	5	67	1	0	1	1	0	0	0	0	0	8518	1335	47	0	1718	0	KRT5	12	52913991	Frame_Shift_Ins	INS	-	TCGA-CN-5373-01A-01D-1434-08	140	52913991	80937904	108	13683											
RAB3IP	117177	broad.mit.edu	37	chr12	70149312	70149312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaccaagtgtcatctacCggccacacccttcagcttta	9	10	5	17	1	4	0	3	0	1	0	4	0	4	0	5	1	2	1	5	1	3	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:70149312C>T	uc001svp.2	+	2	619	c.172C>T	c.(172-174)CGG>TGG	p.R58W	RAB3IP_uc001svl.1_Missense_Mutation_p.R42W|RAB3IP_uc001svm.2_Missense_Mutation_p.R42W|RAB3IP_uc001svn.2_Missense_Mutation_p.R42W|RAB3IP_uc001svo.2_RNA|RAB3IP_uc001svq.2_Missense_Mutation_p.R58W|RAB3IP_uc001svr.2_RNA|RAB3IP_uc001svs.2_RNA	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	58					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			TGTCATCTACCGGCCACACCC	0.468													31	106					0	0	0	0	T	70149312	T	T	70149312	3	4	67	1	0	0	0	0	1	0	0	0	13003	643	23	1	178	1	RAB3IP	12	70149312	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	17235321	70149312	63702583	109	13684											
SYT1	6857	broad.mit.edu	37	chr12	79611355	79611355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgcctgtcaccactgtcgCgactgttctgccaagcaacg	7	8	9	17	4	2	0	1	0	1	0	3	1	2	0	4	0	3	2	4	0	2	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:79611355C>T	uc001sys.2	+	5	727	c.56C>T	c.(55-57)GCG>GTG	p.A19V	SYT1_uc001syt.2_Missense_Mutation_p.A19V|SYT1_uc001syu.2_Missense_Mutation_p.A19V|SYT1_uc001syv.2_Missense_Mutation_p.A19V	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	19	Vesicular (Potential).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						ACCACTGTCGCGACTGTTCTG	0.527													17	53					0	0	0	0	T	79611355	T	T	79611355	3	4	67	1	0	0	0	0	1	0	0	0	15531	768	27	1	58	1	SYT1	12	79611355	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	9462043	79611355	54240540	110	13685											
PPFIA2	8499	broad.mit.edu	37	chr12	81657105	81657105	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcatcatgctgattccaTgtacttcacgaggaggaaac	12	9	10	10	1	2	1	2	1	0	0	3	4	3	3	1	3	3	3	1	3	2	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:81657105T>C	uc001szo.1	-	31	3781	c.3620A>G	c.(3619-3621)CAT>CGT	p.H1207R	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	1106										ovary(3)|lung(2)|pancreas(1)	6						GCTGATTCCATGTACTTCACG	0.443													33	56					0	0	0	0	C	81657105	C	C	81657105	3	2	67	1	0	0	0	0	1	0	0	0	12365	1464	51	5	161	5	PPFIA2	12	81657105	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	2045750	81657105	52194790	111	13686											
EP400	57634	broad.mit.edu	37	chr12	132546772	132546772	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggcaacgactcagggtgttCgagcggtcacttctgtgaca	8	10	13	10	3	3	1	2	1	1	0	4	3	3	1	0	3	2	2	0	3	1	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr12:132546772C>T	uc001ujn.2	+	45	8037	c.8002C>T	c.(8002-8004)CGA>TGA	p.R2668*	EP400_uc001ujl.2_Nonsense_Mutation_p.R2667*|EP400_uc001ujm.2_Nonsense_Mutation_p.R2587*|EP400_uc001ujp.2_5'Flank	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2704	Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TCAGGGTGTTCGAGCGGTCAC	0.667													28	109					0	0	0	0	T	132546772	T	T	132546772	4	4	67	1	0	0	0	0	0	1	0	0	5173	876	31	1	8177	1	EP400	12	132546772	Nonsense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	50889667	132546772	1305123	112	13687											
WASF3	10810	broad.mit.edu	37	chr13	27216530	27216530	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccgctatcatacgccagctGagcagtctgagtaagccatc	10	8	10	13	2	2	2	1	2	1	0	3	2	2	2	3	0	4	4	3	0	3	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr13:27216530G>A	uc001uqv.2	+	3	348	c.123G>A	c.(121-123)CTG>CTA	p.L41L	WASF3_uc001uqw.2_Silent_p.L41L	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	41					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		TACGCCAGCTGAGCAGTCTGA	0.418													7	217					0	0	0	0	A	27216530	A	A	27216530	2	1	67	1	0	0	0	0	0	0	0	1	17322	1277	45	2		2	WASF3	13	27216530	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08		27216530	87953348	113	13688											
AKAP11	11215	broad.mit.edu	37	chr13	42876708	42876708	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaagctgagaaaatagcaAaagtccgaaattgtatgctt	17	9	9	6	1	0	2	0	1	0	2	1	4	1	2	1	0	3	4	1	0	8	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr13:42876708A>G	uc001uys.1	+	8	4001	c.3826A>G	c.(3826-3828)AAA>GAA	p.K1276E		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1276					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GAAAATAGCAAAAGTCCGAAA	0.373													26	95					0	0	0	0	G	42876708	G	G	42876708	3	3	67	1	0	0	0	0	1	0	0	0	447	15	1	5	3848	5	AKAP11	13	42876708	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	15660178	42876708	72293170	114	13689											
AKAP11	11215	broad.mit.edu	37	chr13	42876731	42876731	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccgaaattgtatgcttttCaagcaaaagaagaacagttg	15	11	9	6	1	1	2	1	0	0	2	2	3	2	2	1	0	3	4	1	0	7	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr13:42876731C>T	uc001uys.1	+	8	4024	c.3849C>T	c.(3847-3849)TTC>TTT	p.F1283F		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1283					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GTATGCTTTTCAAGCAAAAGA	0.383													25	94					0	0	0	0	T	42876731	T	T	42876731	2	4	67	1	0	0	0	0	0	0	0	1	447	825	29	2		2	AKAP11	13	42876731	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	23	42876731	72293147	115	13690											
OR4N5	390437	broad.mit.edu	37	chr14	20612693	20612693	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccccttccaggctttcccaGctgacaaggtagtttctctt	6	13	8	14	0	1	1	0	1	1	0	4	1	3	1	4	2	1	4	4	2	2	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr14:20612693G>T	uc010tla.1	+	1	799	c.799G>T	c.(799-801)GCT>TCT	p.A267S		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GGCTTTCCCAGCTGACAAGGT	0.428													106	402					1.98007e-57	2.21977e-57	1	0	T	20612693	T	T	20612693	3	4	67	1	0	0	0	0	1	0	0	0	11133	971	34	4	801	4	OR4N5	14	20612693	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08		20612693	86736847	116	13691											
FAM179B	23116	broad.mit.edu	37	chr14	45473350	45473350	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctcaaatggtcaaaatccaAgtccaggagcttacatcctt	13	10	6	12	0	2	0	2	0	0	0	5	1	5	1	4	2	2	1	4	2	5	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr14:45473350A>T	uc001wvv.2	+	4	2634	c.2425A>T	c.(2425-2427)AGT>TGT	p.S809C	FAM179B_uc001wvw.2_Missense_Mutation_p.S809C|FAM179B_uc010anc.2_RNA|FAM179B_uc001wvu.2_Missense_Mutation_p.S809C	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	809							binding			skin(2)|upper_aerodigestive_tract(1)	3						TCAAAATCCAAGTCCAGGAGC	0.398													4	89					0	0	0	0	T	45473350	T	T	45473350	3	4	67	1	0	0	0	0	1	0	0	0	5534	72	3	5	2439	5	FAM179B	14	45473350	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	24860657	45473350	61876190	117	13692											
TMEM30B	161291	broad.mit.edu	37	chr14	61746909	61746909	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagccgacgaccaggtaggcGatgcccaggaaggggttctt	9	6	16	10	3	1	0	0	0	1	0	1	5	1	1	3	5	2	2	3	5	2	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr14:61746909G>A	uc001xfl.2	-	1	1622	c.957C>T	c.(955-957)ATC>ATT	p.I319I	PRKCH_uc010tsa.1_Intron|TMEM30B_uc010apr.1_RNA	NM_001017970	NP_001017970	Q3MIR4	CC50B_HUMAN	transmembrane protein 30B	319	Helical; (Potential).					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(108;0.107)|BRCA - Breast invasive adenocarcinoma(234;0.181)		CCAGGTAGGCGATGCCCAGGA	0.602													10	42					0	0	0	0	A	61746909	A	A	61746909	2	1	67	1	0	0	0	0	0	0	0	1	16220	1048	37	1		1	TMEM30B	14	61746909	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	16273559	61746909	45602631	118	13693											
SYNE2	23224	broad.mit.edu	37	chr14	64464044	64464044	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccatcaccacatctgagaatAgaggaggggatccccacagt	13	6	10	12	0	2	2	1	1	1	2	3	5	3	4	4	3	0	0	4	3	2	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr14:64464044A>G	uc001xgm.2	+	25	3408	c.3178A>G	c.(3178-3180)AGA>GGA	p.R1060G	SYNE2_uc001xgl.2_Missense_Mutation_p.R1060G	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1060	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATCTGAGAATAGAGGAGGGGA	0.383													6	32					0	0	0	0	G	64464044	G	G	64464044	3	3	67	1	0	0	0	0	1	0	0	0	15512	412	15	5	3272	5	SYNE2	14	64464044	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	2717135	64464044	42885496	119	13694											
SNRPN	6638	broad.mit.edu	37	chr15	25222159	25222159	+	Frame_Shift_Del	DEL	G	-	-																															caggccctgtccgaggagttGggggaccatcccagcaggtg																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:25222159delG	uc001ywp.1	+	10	1293	c.403delG	c.(403-405)GGGfs	p.G135fs	SNRPN_uc001ywq.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001ywr.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001yws.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001ywt.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001ywv.1_Frame_Shift_Del_p.G138fs|SNRPN_uc001yww.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001ywx.1_Frame_Shift_Del_p.G135fs|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	135					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		CCGAGGAGTTGGGGGACCATC	0.557									Prader-Willi_syndrome				---	---	---								-	25222159	-	-	25222159	7	5	67	1	0	1	0	1	0	0	0	0	14934	1348	47	0	417	0	SNRPN	15	25222159	Frame_Shift_Del	DEL	G	TCGA-CN-5373-01A-01D-1434-08		25222159	77309233	120	13695											
GABRA5	2558	broad.mit.edu	37	chr15	27193231	27193231	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctctgaagagaagacttctGaaagcaaaaagacttacaac	18	7	7	9	0	2	5	0	2	2	3	2	6	2	5	1	0	3	1	1	0	7	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:27193231G>A	uc001zbd.1	+	12	1579	c.1240G>A	c.(1240-1242)GAA>AAA	p.E414K	GABRA5_uc001zbe.1_RNA	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	414	Cytoplasmic (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GAAGACTTCTGAAAGCAAAAA	0.448													7	18					0	0	0	0	A	27193231	A	A	27193231	3	1	67	1	0	0	0	0	1	0	0	0	6198	1291	45	2	1274	2	GABRA5	15	27193231	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	1971072	27193231	75338161	121	13696											
GATM	2628	broad.mit.edu	37	chr15	45658345	45658345	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggatctttaaaggagatgaTatgcactctgtagtctggag	11	12	13	5	0	3	2	0	1	3	1	3	5	3	4	0	3	1	2	0	3	4	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:45658345T>C	uc001zvc.2	-	6	1206	c.877A>G	c.(877-879)ATC>GTC	p.I293V	GATM_uc001zvb.2_Missense_Mutation_p.I164V|GATM_uc010uev.1_Missense_Mutation_p.I346V	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	293					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	AAGGAGATGATATGCACTCTG	0.418													34	92					0	0	0	0	C	45658345	C	C	45658345	3	2	67	1	0	0	0	0	1	0	0	0	6298	1406	49	5	410	5	GATM	15	45658345	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	18465114	45658345	56873047	122	13697											
CLPX	10845	broad.mit.edu	37	chr15	65472462	65472462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtttctgtaaaggatctaaGaggagctctttgcagaatct	11	14	10	6	0	4	2	0	0	4	2	4	4	4	4	0	2	2	4	0	2	4	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:65472462G>A	uc002aom.2	-	2	232	c.160C>T	c.(160-162)CTT>TTT	p.L54F	CLPX_uc010uiu.1_RNA|CLPX_uc010bhg.1_Missense_Mutation_p.L54F	NM_006660	NP_006651	O76031	CLPX_HUMAN	ClpX caseinolytic protease X homolog precursor	54					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding				0						AAGGATCTAAGAGGAGCTCTT	0.363													32	154					0	0	0	0	A	65472462	A	A	65472462	3	1	67	1	0	0	0	0	1	0	0	0	3571	942	33	2	1793	2	CLPX	15	65472462	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	19814117	65472462	37058930	123	13698											
NMB	4828	broad.mit.edu	37	chr15	85201301	85201301	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggctccgggagatcccagCtgagcggggcgacgccggca	6	3	19	13	5	0	2	0	1	0	1	2	4	2	2	3	6	2	3	3	6	0	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr15:85201301C>T	uc002bkz.2	-	1	502	c.83G>A	c.(82-84)AGC>AAC	p.S28N	NMB_uc002bla.2_Missense_Mutation_p.S28N	NM_021077	NP_066563	P08949	NMB_HUMAN	neuromedin B isoform 1	28					cell-cell signaling|neuropeptide signaling pathway	extracellular region|soluble fraction	hormone activity				0				all cancers(203;3.5e-06)		GAGATCCCAGCTGAGCGGGGC	0.622													9	17					0	0	0	0	T	85201301	T	T	85201301	3	4	67	1	0	0	0	0	1	0	0	0	10540	797	28	4	398	4	NMB	15	85201301	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	19728839	85201301	17330091	124	13699											
RAB11FIP3	9727	broad.mit.edu	37	chr16	532707	532707	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacgccatggaggagcccgaCcatggtgccctgctgctgct	6	7	14	14	2	0	0	0	0	0	0	0	4	0	2	4	3	5	3	4	3	0	0	rs139755055	byFrequency	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:532707C>T	uc002chf.2	+	4	1425	c.1086C>T	c.(1084-1086)GAC>GAT	p.D362D	RAB11FIP3_uc010uuf.1_Silent_p.D66D|RAB11FIP3_uc010uug.1_Silent_p.D52D	NM_014700	NP_055515	O75154	RFIP3_HUMAN	rab11-family interacting protein 3 isoform 1	362					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding				0		Hepatocellular(16;0.0218)				AGGAGCCCGACCATGGTGCCC	0.687													6	16					0	0	0	0	T	532707	T	T	532707	2	4	67	1	0	0	0	0	0	0	0	1	12960	506	18	4		4	RAB11FIP3	16	532707	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08		532707	89822046	125	13700											
MAPK8IP3	23162	broad.mit.edu	37	chr16	1756596	1756596	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agctggagctgctgcgcgagGacaacgagcagctgctcacc	9	5	14	13	3	1	0	1	0	0	0	1	4	1	2	1	2	8	6	1	2	1	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:1756596G>A	uc002cmk.2	+	1	376	c.256G>A	c.(256-258)GAC>AAC	p.D86N	MAPK8IP3_uc002cmi.1_Missense_Mutation_p.D86N|MAPK8IP3_uc002cmj.1_RNA|MAPK8IP3_uc002cml.2_Missense_Mutation_p.D86N|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.D86N	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	86	Potential.				vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						GCTGCGCGAGGACAACGAGCA	0.592													3	13					0	0	0	0	A	1756596	A	A	1756596	3	1	67	1	0	0	0	0	1	0	0	0	9339	1174	41	2	258	2	MAPK8IP3	16	1756596	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	1223889	1756596	88598157	126	13701											
MGRN1	23295	broad.mit.edu	37	chr16	4731639	4731639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtctccccggccatcccctCggcccctctttatgaagaaa	7	10	7	17	2	2	2	0	1	2	1	5	2	3	2	7	2	0	0	7	2	3	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:4731639C>T	uc002cwz.2	+	13	1356	c.1220C>T	c.(1219-1221)TCG>TTG	p.S407L	MGRN1_uc002cxa.2_Missense_Mutation_p.S407L|MGRN1_uc010btx.2_Missense_Mutation_p.S386L|MGRN1_uc010btw.2_Missense_Mutation_p.S386L|MGRN1_uc002cxb.2_Missense_Mutation_p.S446L|MGRN1_uc010uxo.1_Missense_Mutation_p.S385L|MGRN1_uc010uxp.1_Missense_Mutation_p.S385L|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	407	Required for TSG101-binding.			PSAP->ASAA: Loss of TSG101-binding and drastic reduction of TSG101- ubiquitination.	endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						GCCATCCCCTCGGCCCCTCTT	0.637													6	128					0	0	0	0	T	4731639	T	T	4731639	3	4	67	1	0	0	0	0	1	0	0	0	9612	893	31	1	1273	1	MGRN1	16	4731639	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	2975043	4731639	85623114	127	13702											
C16orf71	146562	broad.mit.edu	37	chr16	4787863	4787863	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caaacctccctgattccagaCctgtcggaggagctggctga	9	8	11	13	1	0	3	0	2	0	1	3	5	2	5	4	3	2	2	4	3	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:4787863C>A	uc002cxn.2	+	3	654	c.192C>A	c.(190-192)GAC>GAA	p.D64E		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	64										central_nervous_system(1)	1						TGATTCCAGACCTGTCGGAGG	0.577													29	98					2.36697e-06	2.49587e-06	1	0	A	4787863	A	A	4787863	3	1	67	1	0	0	0	0	1	0	0	0	1836	506	18	4	198	4	C16orf71	16	4787863	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	56224	4787863	85566890	128	13703											
C16orf72	29035	broad.mit.edu	37	chr16	9210684	9210684	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatggcactccacttggacaAtggtggaactagaaagcgta	14	8	11	8	1	0	1	0	0	0	1	1	3	1	3	1	4	2	2	1	4	6	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:9210684A>G	uc002czm.2	+	4	1108	c.743A>G	c.(742-744)AAT>AGT	p.N248S		NM_014117	NP_054836	Q14CZ0	CP072_HUMAN	hypothetical protein LOC29035	248										large_intestine(1)	1						CACTTGGACAATGGTGGAACT	0.438													41	139					0	0	0	0	G	9210684	G	G	9210684	3	3	67	1	0	0	0	0	1	0	0	0	1837	101	4	5	757	5	C16orf72	16	9210684	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	4422821	9210684	81144069	129	13704											
ZNF319	57567	broad.mit.edu	37	chr16	58031444	58031444	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtggtgcaccaggtgcgaCgactggctgaagcttttgtc	6	12	14	9	2	0	1	0	1	0	0	1	3	0	1	1	3	3	3	1	3	1	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr16:58031444C>T	uc002emx.1	-	2	1349	c.726G>A	c.(724-726)TCG>TCA	p.S242S		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	242	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCAGGTGCGACGACTGGCTGA	0.617													43	155					0	0	0	0	T	58031444	T	T	58031444	2	4	67	1	0	0	0	0	0	0	0	1	17904	523	19	1		1	ZNF319	16	58031444	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	48820760	58031444	32323309	130	13705											
TP53	7157	broad.mit.edu	37	chr17	7577547	7577547	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggatgggcctccggttcatgCcgcccatgcaggaactgtta	7	9	13	12	2	1	0	1	0	0	0	2	2	2	2	4	4	3	3	4	4	2	2	rs121912656		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:7577547C>A	uc002gim.2	-	7	928	c.734G>T	c.(733-735)GGC>GTC	p.G245V	TP53_uc002gig.1_Missense_Mutation_p.G245V|TP53_uc002gih.2_Missense_Mutation_p.G245V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113V|TP53_uc010cng.1_Missense_Mutation_p.G113V|TP53_uc002gii.1_Missense_Mutation_p.G113V|TP53_uc010cnh.1_Missense_Mutation_p.G245V|TP53_uc010cni.1_Missense_Mutation_p.G245V|TP53_uc002gij.2_Missense_Mutation_p.G245V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152V|TP53_uc002gio.2_Missense_Mutation_p.G113V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245del(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.S241_G245delSCMGG(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	42					1.22384e-17	1.32998e-17	1	0	A	7577547	A	A	7577547	3	1	67	1	0	0	0	0	1	0	0	0	16448	739	26	4	556	4	TP53	17	7577547	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08		7577547	73617663	131	13706											
CHD3	1107	broad.mit.edu	37	chr17	7810280	7810280	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgctcctccagagcctccTctcctaccaaaacgtctccc	8	8	5	20	2	2	1	0	0	2	1	7	1	5	1	7	0	4	1	7	0	3	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:7810280T>C	uc002gje.2	+	30	4747	c.4597T>C	c.(4597-4599)TCT>CCT	p.S1533P	CHD3_uc002gjd.2_Missense_Mutation_p.S1592P|CHD3_uc002gjf.2_Missense_Mutation_p.S1533P|CHD3_uc002gjh.2_Missense_Mutation_p.S109P|CHD3_uc002gjj.2_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1533					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				CAGAGCCTCCTCTCCTACCAA	0.562													61	260					0	0	0	0	C	7810280	C	C	7810280	3	2	67	1	0	0	0	0	1	0	0	0	3341	1551	54	5	4996	5	CHD3	17	7810280	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	232733	7810280	73384930	132	13707											
PFAS	5198	broad.mit.edu	37	chr17	8167250	8167250	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcaccatcactggagaccGgagagtgagttggcccaggg	9	5	17	10	1	1	3	1	1	0	2	1	5	1	3	3	5	0	2	3	5	0	1	rs142452570	byFrequency	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:8167250G>A	uc002gkr.2	+	15	1928	c.1787G>A	c.(1786-1788)CGG>CAG	p.R596Q	PFAS_uc010vuv.1_Missense_Mutation_p.R172Q|PFAS_uc010cnw.1_Intron|PFAS_uc002gks.2_5'Flank	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	596					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	ACTGGAGACCGGAGAGTGAGT	0.597													39	118					0	0	0	0	A	8167250	A	A	8167250	3	1	67	1	0	0	0	0	1	0	0	0	11809	1116	39	1	1841	1	PFAS	17	8167250	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	356970	8167250	73027960	133	13708											
MYH13	8735	broad.mit.edu	37	chr17	10222179	10222179	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagctcgctcttctccttCtccagcttctgcttcacccg	3	15	5	18	2	6	0	2	0	4	0	9	0	6	0	3	0	3	4	3	0	0	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:10222179C>T	uc002gmk.1	-	27	3756	c.3666G>A	c.(3664-3666)GAG>GAA	p.E1222E		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1222	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCTTCTCCTTCTCCAGCTTCT	0.557													27	168					0	0	0	0	T	10222179	T	T	10222179	2	4	67	1	0	0	0	0	0	0	0	1	10085	912	32	2		2	MYH13	17	10222179	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	2054929	10222179	70973031	134	13709											
MYH8	4626	broad.mit.edu	37	chr17	10304723	10304723	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttctccttggacagttttgCaatggtttcatccaggcctg	6	15	9	11	0	2	0	1	0	1	0	4	1	3	1	3	3	1	3	3	3	1	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:10304723C>A	uc002gmm.2	-	24	3072	c.2977G>T	c.(2977-2979)GCA>TCA	p.A993S	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	993	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GACAGTTTTGCAATGGTTTCA	0.458									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				62	219					7.41606e-26	8.10061e-26	1	0	A	10304723	A	A	10304723	3	1	67	1	0	0	0	0	1	0	0	0	10094	710	25	4	2904	4	MYH8	17	10304723	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	82544	10304723	70890487	135	13710											
ALKBH5	54890	broad.mit.edu	37	chr17	18110247	18110247	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accctgctctgaaacccaagCggtcccaccgcaaggcagac	11	4	9	17	2	1	2	0	1	1	1	2	2	2	2	4	2	3	3	4	2	3	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:18110247C>T	uc010cpw.2	+	3	1661	c.970C>T	c.(970-972)CGG>TGG	p.R324W	ALKBH5_uc010cpx.2_RNA	NM_017758	NP_060228	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5	324						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_neural(463;0.228)					GAAACCCAAGCGGTCCCACCG	0.587													75	319					0	0	0	0	T	18110247	T	T	18110247	3	4	67	1	0	0	0	0	1	0	0	0	530	759	27	1	980	1	ALKBH5	17	18110247	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	7805524	18110247	63084963	136	13711											
ACCN1	40	broad.mit.edu	37	chr17	31415907	31415907	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgtgtggccacaaaggTctggaaccctggagccaccc	8	7	11	15	0	1	0	0	0	1	0	2	2	2	2	5	4	2	0	5	4	2	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:31415907T>C	uc002hhu.2	-	3	1082	c.808A>G	c.(808-810)ACC>GCC	p.T270A	ACCN1_uc002hht.2_Missense_Mutation_p.T321A	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	270	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	GCCACAAAGGTCTGGAACCCT	0.572													13	33					0	0	0	0	C	31415907	C	C	31415907	3	2	67	1	0	0	0	0	1	0	0	0	128	1667	58	5	762	5	ACCN1	17	31415907	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	13305660	31415907	49779303	137	13712											
KRT36	8689	broad.mit.edu	37	chr17	39643670	39643670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctcagctcgatgatctccGtctggcagcactgcagctgc	6	10	11	14	2	3	1	1	1	3	0	6	2	3	1	1	1	5	5	1	1	0	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:39643670G>A	uc002hwt.2	-	5	920	c.920C>T	c.(919-921)ACG>ATG	p.T307M		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	307	Rod.|Coil 2.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				GATGATCTCCGTCTGGCAGCA	0.612													3	44					0	0	0	0	A	39643670	A	A	39643670	3	1	67	1	0	0	0	0	1	0	0	0	8512	1145	40	1	495	1	KRT36	17	39643670	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	8227763	39643670	41551540	138	13713											
TUBG1	7283	broad.mit.edu	37	chr17	40765019	40765019	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcccaaccaggacgagatGagcgatgtggtggtccagcc	9	8	13	11	2	0	2	0	1	0	1	2	5	2	3	4	3	3	0	4	3	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:40765019G>A	uc002ian.2	+	6	932	c.534G>A	c.(532-534)ATG>ATA	p.M178I		NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	178					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		AGGACGAGATGAGCGATGTGG	0.542													53	138					0	0	0	0	A	40765019	A	A	40765019	3	1	67	1	0	0	0	0	1	0	0	0	16832	1290	45	2	556	2	TUBG1	17	40765019	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	1121349	40765019	40430191	139	13714											
AOC2	314	broad.mit.edu	37	chr17	40996984	40996984	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacctggacagggggagccCcccacctgcccgggaggcac	7	2	14	18	1	0	0	0	0	0	0	0	3	0	3	7	5	2	1	7	5	0	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:40996984C>T	uc002ibu.2	+	1	376	c.341C>T	c.(340-342)CCC>CTC	p.P114L	AOC2_uc002ibt.2_Missense_Mutation_p.P114L	NM_009590	NP_033720	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 isoform b	114					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			ovary(2)	2		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		AGGGGGAGCCCCCCACCTGCC	0.677													29	86					0	0	0	0	T	40996984	T	T	40996984	3	4	67	1	0	0	0	0	1	0	0	0	727	623	22	4	343	4	AOC2	17	40996984	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	231965	40996984	40198226	140	13715											
WNT9B	7484	broad.mit.edu	37	chr17	44949908	44949908	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgggcgggaagtcctgacgCccttcccaggattgggcact	6	7	14	14	3	0	1	0	1	0	0	2	3	2	3	4	4	0	1	4	4	1	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:44949908C>G	uc002ikw.1	+	2	140	c.103C>G	c.(103-105)CCC>GCC	p.P35A	WNT9B_uc002ikx.1_Missense_Mutation_p.P35A	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	35					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			AGTCCTGACGCCCTTCCCAGG	0.667													51	202					0	0	0	0	G	44949908	G	G	44949908	3	3	67	1	0	0	0	0	1	0	0	0	17467	739	26	4	109	4	WNT9B	17	44949908	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	3952924	44949908	36245302	141	13716											
C17orf67	339210	broad.mit.edu	37	chr17	54872507	54872507	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggaactgctcctcagcgCgatgctccagggcgagcagg	8	5	14	14	3	1	0	1	0	0	0	3	3	3	1	3	3	5	3	3	3	1	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:54872507C>T	uc010dci.2	-	3	270	c.263G>A	c.(262-264)CGC>CAC	p.R88H	C17orf67_uc002iuq.2_RNA	NM_001085430	NP_001078899	Q0P5P2	CQ067_HUMAN	hypothetical protein LOC339210 precursor	88						extracellular region					0	Breast(9;2.49e-06)					CTCCTCAGCGCGATGCTCCAG	0.547													13	49					0	0	0	0	T	54872507	T	T	54872507	3	4	67	1	0	0	0	0	1	0	0	0	1882	768	27	1	85	1	C17orf67	17	54872507	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	9922599	54872507	26322703	142	13717											
EPX	8288	broad.mit.edu	37	chr17	56274611	56274611	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcggcgcgcatcccctgcttCctggcaggtcagacagggag	6	7	14	14	3	1	1	1	0	0	1	4	2	3	2	3	4	1	3	3	4	0	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:56274611C>T	uc002ivq.2	+	7	1199	c.1113C>T	c.(1111-1113)TTC>TTT	p.F371F		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	371					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						TCCCCTGCTTCCTGGCAGGTC	0.617													28	75					0	0	0	0	T	56274611	T	T	56274611	2	4	67	1	0	0	0	0	0	0	0	1	5224	854	30	2		2	EPX	17	56274611	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	1402104	56274611	24920599	143	13718											
GH2	2689	broad.mit.edu	37	chr17	61957832	61957832	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttgtgtcaaacttgctgtagGactgattgaagatctgccca	10	13	10	8	0	2	3	1	2	1	1	2	4	2	4	1	1	3	2	1	1	3	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:61957832G>A	uc002jco.1	-	5	565	c.503C>T	c.(502-504)TCC>TTC	p.S168F	GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_Silent_p.V252V|GH2_uc002jcm.1_Missense_Mutation_p.P167S|GH2_uc002jcn.1_Missense_Mutation_p.S153F	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	168						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						CTTGCTGTAGGACTGATTGAA	0.542													38	133					0	0	0	0	A	61957832	A	A	61957832	3	1	67	1	0	0	0	0	1	0	0	0	6405	1174	41	2	242	2	GH2	17	61957832	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	5683221	61957832	19237378	144	13719											
SCN4A	6329	broad.mit.edu	37	chr17	62018859	62018859	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagttctccaggatgatggCgatgtacatgttgaccacga	11	10	12	8	2	1	2	0	2	1	0	2	6	1	3	2	2	1	3	2	2	2	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:62018859C>T	uc002jds.1	-	24	4860	c.4783G>A	c.(4783-4785)GCC>ACC	p.A1595T		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1595	IV.|Helical; Name=S6 of repeat IV; (Potential).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	AGGATGATGGCGATGTACATG	0.517													22	70					0	0	0	0	T	62018859	T	T	62018859	3	4	67	1	0	0	0	0	1	0	0	0	13985	768	27	1	731	1	SCN4A	17	62018859	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	61027	62018859	19176351	145	13720											
WIPI1	55062	broad.mit.edu	37	chr17	66426234	66426234	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctgacacctgggtagggaGgtagttggtagcagccataa	10	9	15	7	0	1	1	0	1	1	0	1	2	1	2	2	4	2	5	2	4	4	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr17:66426234G>T	uc010dey.2	-	9	959	c.868C>A	c.(868-870)CTC>ATC	p.L290I	WIPI1_uc002jhd.3_RNA|WIPI1_uc010wqo.1_Missense_Mutation_p.L208I|WIPI1_uc002jhe.3_RNA	NM_017983	NP_060453	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting	290					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding				0						TGGGTAGGGAGGTAGTTGGTA	0.527													26	90					3.17567e-06	3.33211e-06	1	0	T	66426234	T	T	66426234	3	4	67	1	0	0	0	0	1	0	0	0	17438	1000	35	4	492	4	WIPI1	17	66426234	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	4407375	66426234	14768976	146	13721											
DCC	1630	broad.mit.edu	37	chr18	50923746	50923746	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacacaatgtatgaattctcGgtcatggtaacaaaaaacag	18	9	7	7	1	2	1	1	1	1	0	3	1	2	1	0	2	3	2	0	2	8	3	rs144874430		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr18:50923746G>A	uc002lfe.1	+	18	3344	c.2757G>A	c.(2755-2757)TCG>TCA	p.S919S	DCC_uc010xdr.1_Silent_p.S747S|DCC_uc010dpf.1_Silent_p.S554S	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	919	Extracellular (Potential).|Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ATGAATTCTCGGTCATGGTAA	0.413													3	86					0	0	0	0	A	50923746	A	A	50923746	2	1	67	1	0	0	0	0	0	0	0	1	4299	1103	39	1		1	DCC	18	50923746	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08		50923746	27153502	147	13722											
TXNL1	9352	broad.mit.edu	37	chr18	54291640	54291640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatcaattctcactttgtttCgaaaaaacaaaaatgtaggt	16	13	6	6	1	2	0	2	0	1	0	4	2	2	0	0	1	1	2	0	1	7	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr18:54291640C>T	uc002lgg.2	-	3	497	c.248G>A	c.(247-249)CGA>CAA	p.R83Q	TXNL1_uc010xdz.1_RNA|TXNL1_uc002lgh.2_RNA|TXNL1_uc002lgi.2_Missense_Mutation_p.R83Q|TXNL1_uc002lgj.1_Missense_Mutation_p.R83Q	NM_004786	NP_004777	O43396	TXNL1_HUMAN	thioredoxin-like 1	83	Thioredoxin.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		CACTTTGTTTCGAAAAAACAA	0.378													60	163					0	0	0	0	T	54291640	T	T	54291640	3	4	67	1	0	0	0	0	1	0	0	0	16872	884	31	1	645	1	TXNL1	18	54291640	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	3367894	54291640	23785608	148	13723											
FCHO1	23149	broad.mit.edu	37	chr19	17888953	17888953	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaccctctctagctgtgcaGagagattgcagtcagaggag	10	9	12	10	0	3	3	2	0	1	3	4	5	3	4	1	1	3	3	1	1	1	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:17888953G>A	uc010ebb.2	+	18	1456	c.1267G>A	c.(1267-1269)GAG>AAG	p.E423K	FCHO1_uc002nhg.3_Missense_Mutation_p.E423K|FCHO1_uc002nhh.2_Missense_Mutation_p.E423K|FCHO1_uc010xpw.1_Missense_Mutation_p.E373K|FCHO1_uc002nhi.2_5'Flank|FCHO1_uc002nhj.2_5'Flank	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	423										breast(1)	1						TAGCTGTGCAGAGAGATTGCA	0.393													3	95					0	0	0	0	A	17888953	A	A	17888953	3	1	67	1	0	0	0	0	1	0	0	0	5819	943	33	2	1329	2	FCHO1	19	17888953	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08		17888953	41240030	149	13724											
ZNF506	440515	broad.mit.edu	37	chr19	19905666	19905666	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggttttgccacattcgtCacatttgtagggtacatctc	10	14	8	9	1	2	0	1	0	1	0	4	0	2	0	1	2	2	3	1	2	3	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:19905666C>T	uc010eci.2	-	4	1178	c.1030G>A	c.(1030-1032)GAC>AAC	p.D344N	ZNF506_uc002nog.2_Intron|ZNF506_uc002noh.3_Missense_Mutation_p.D312N	NM_001099269	NP_001092739	Q5JVG8	ZN506_HUMAN	zinc finger protein 506 isoform 1	344	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding				0						CCACATTCGTCACATTTGTAG	0.413													5	174					0	0	0	0	T	19905666	T	T	19905666	3	4	67	1	0	0	0	0	1	0	0	0	18019	826	29	2	308	2	ZNF506	19	19905666	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	2016713	19905666	39223317	150	13725											
ZNF99	7652	broad.mit.edu	37	chr19	22939037	22939037	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccccagtatgaattatcttAtgtttagtaagggctgaaag	12	14	9	6	0	1	2	0	2	1	0	2	2	2	2	2	1	0	4	2	1	7	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:22939037A>T	uc010xrh.1	-	8	3081	c.3081T>A	c.(3079-3081)CAT>CAA	p.H1027Q		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GAATTATCTTATGTTTAGTAA	0.333													52	135					0	0	0	0	T	22939037	T	T	22939037	3	4	67	1	0	0	0	0	1	0	0	0	18271	446	16	5	31	5	ZNF99	19	22939037	Missense_Mutation	SNP	A	TCGA-CN-5373-01A-01D-1434-08	3033371	22939037	36189946	151	13726											
DYRK1B	9149	broad.mit.edu	37	chr19	40319149	40319149	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtgttgcgcaggaggtCgtacaggttgtaggacagca	8	9	18	6	2	0	0	0	0	0	0	1	2	0	2	0	5	3	6	0	5	2	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:40319149C>A	uc002omj.2	-	6	875	c.595G>T	c.(595-597)GAC>TAC	p.D199Y	DYRK1B_uc002omi.2_Missense_Mutation_p.D199Y|DYRK1B_uc002omk.2_Missense_Mutation_p.D199Y	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	199	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CGCAGGAGGTCGTACAGGTTG	0.622													6	10					0.00116845	0.00120815	1	0	A	40319149	A	A	40319149	3	1	67	1	0	0	0	0	1	0	0	0	4877	884	31	3	1318	3	DYRK1B	19	40319149	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	17380112	40319149	18809834	152	13727											
DHX34	9704	broad.mit.edu	37	chr19	47856739	47856739	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaagcaggcatttgggcGtctggccaagctgcagcgtg	8	7	15	11	2	1	1	0	0	1	1	1	1	1	1	2	3	4	4	2	3	2	1	rs149967464	by1000genomes	TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:47856739G>A	uc010xyn.1	+	2	793	c.452G>A	c.(451-453)CGT>CAT	p.R151H	DHX34_uc010elc.1_Missense_Mutation_p.R151H	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	151						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GCATTTGGGCGTCTGGCCAAG	0.647													35	65					0	0	0	0	A	47856739	A	A	47856739	3	1	67	1	0	0	0	0	1	0	0	0	4529	1145	40	1	454	1	DHX34	19	47856739	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	7537590	47856739	11272244	153	13728											
RASIP1	54922	broad.mit.edu	37	chr19	49238477	49238477	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgtcctggtagccctggagCagcaggaagtaggggcggtt	7	7	18	9	2	0	0	0	0	0	0	1	2	1	2	2	6	3	5	2	6	3	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:49238477C>T	uc002pki.2	-	4	1352	c.1155G>A	c.(1153-1155)CTG>CTA	p.L385L		NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	385					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		AGCCCTGGAGCAGCAGGAAGT	0.637													7	30					0	0	0	0	T	49238477	T	T	49238477	2	4	67	1	0	0	0	0	0	0	0	1	13143	697	25	4		4	RASIP1	19	49238477	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	1381738	49238477	9890506	154	13729											
ZNF808	388558	broad.mit.edu	37	chr19	53057763	53057763	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttgtataccatcgtagaCttcacactctagagaaatct	12	12	5	12	1	3	2	1	0	2	2	4	3	3	2	2	0	1	2	2	0	5	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:53057763C>G	uc010epq.1	+	5	1771	c.1594C>G	c.(1594-1596)CTT>GTT	p.L532V	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	532	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CCATCGTAGACTTCACACTCT	0.413													59	251					0	0	0	0	G	53057763	G	G	53057763	3	3	67	1	0	0	0	0	1	0	0	0	18240	565	20	4	1604	4	ZNF808	19	53057763	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	3819286	53057763	6071220	155	13730											
SAPS1	22870	broad.mit.edu	37	chr19	55752732	55752732	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccagaggcggagccagcaTgccccatgtcatctgtagcg	8	6	13	14	2	2	1	1	0	1	1	2	2	2	2	4	2	4	2	4	2	1	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:55752732T>C	uc002qjw.3	-	9	1278	c.1036A>G	c.(1036-1038)ATG>GTG	p.M346V	SAPS1_uc002qjv.2_Missense_Mutation_p.M408V	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	346	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		GGAGCCAGCATGCCCCATGTC	0.667													12	40					0	0	0	0	C	55752732	C	C	55752732	3	2	67	1	0	0	0	0	1	0	0	0	13901	1464	51	5	1673	5	SAPS1	19	55752732	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	2694969	55752732	3376251	156	13731											
ZNF579	163033	broad.mit.edu	37	chr19	56089543	56089543	+	Frame_Shift_Del	DEL	G	-	-																															gctcggccttcaggggcggcGggggcggtggcggcgacgtc																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:56089543delG	uc002qlh.2	-	2	1516	c.1463delC	c.(1462-1464)CCGfs	p.P488fs		NM_152600	NP_689813	Q8NAF0	ZN579_HUMAN	zinc finger protein 579	488	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.106)		CAGGggcggcgggggcggtgg	0.318													---	---	---								-	56089543	-	-	56089543	7	5	67	1	0	1	0	1	0	0	0	0	18078	1116	39	0	229	0	ZNF579	19	56089543	Frame_Shift_Del	DEL	G	TCGA-CN-5373-01A-01D-1434-08	336811	56089543	3039440	157	13732											
ZNF134	7693	broad.mit.edu	37	chr19	58132398	58132398	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagacacaaatctacacttgTtcagcatgagagtattcaca	15	10	6	10	0	3	2	2	1	1	2	3	3	3	2	0	0	2	3	0	0	3	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:58132398T>A	uc002qpn.2	+	3	1010	c.911T>A	c.(910-912)GTT>GAT	p.V304D	ZNF134_uc002qpo.2_Missense_Mutation_p.V131D|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	304	C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		TCTACACTTGTTCAGCATGAG	0.408													57	211					0	0	0	0	A	58132398	A	A	58132398	3	1	67	1	0	0	0	0	1	0	0	0	17791	1725	60	5	917	5	ZNF134	19	58132398	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	2042855	58132398	996585	158	13733											
C19orf18	147685	broad.mit.edu	37	chr19	58472909	58472909	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttgtctttcctcagcctGtgccagtcgactggagaatg	6	13	11	11	1	2	1	1	0	1	1	4	3	3	1	3	1	2	1	3	1	1	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr19:58472909G>A	uc002qqv.2	-	5	486	c.382C>T	c.(382-384)CAG>TAG	p.Q128*		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	128	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		TCCTCAGCCTGTGCCAGTCGA	0.428													50	147					0	0	0	0	A	58472909	A	A	58472909	4	1	67	1	0	0	0	0	0	1	0	0	1919	1386	48	4	273	4	C19orf18	19	58472909	Nonsense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	340511	58472909	656074	159	13734											
PYGB	5834	broad.mit.edu	37	chr20	25239913	25239913	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaattctacatgggtcgcaCgctgcagaacacgatggtga	11	8	13	9	3	1	2	0	1	1	1	2	4	1	3	0	3	3	3	0	3	3	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:25239913C>T	uc002wup.2	+	2	393	c.284C>T	c.(283-285)ACG>ATG	p.T95M		NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	95					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	ATGGGTCGCACGCTGCAGAAC	0.498													31	102					0	0	0	0	T	25239913	T	T	25239913	3	4	67	1	0	0	0	0	1	0	0	0	12925	536	19	1	290	1	PYGB	20	25239913	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08		25239913	37785607	160	13735											
PLCG1	5335	broad.mit.edu	37	chr20	39792085	39792085	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctccgagaccccttacGagagatcgaggagccatact	10	8	9	14	3	0	2	0	0	0	2	3	7	2	3	5	1	3	0	5	1	2	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:39792085G>T	uc002xjp.1	+	9	978	c.857G>T	c.(856-858)CGA>CTA	p.R286L	PLCG1_uc002xjo.1_Missense_Mutation_p.R286L|PLCG1_uc010zwe.1_5'Flank|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	286					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GACCCCTTACGAGAGATCGAG	0.567													17	61					4.35082e-09	4.63362e-09	1	0	T	39792085	T	T	39792085	3	4	67	1	0	0	0	0	1	0	0	0	12090	1058	37	3	891	3	PLCG1	20	39792085	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	14552172	39792085	23233435	161	13736											
SERINC3	10955	broad.mit.edu	37	chr20	43133498	43133498	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tagtgtagagggtgatgaggGaggactgcaagaggccggag	11	6	20	4	1	0	4	0	2	0	2	0	7	0	7	1	5	1	2	1	5	3	2	rs149223322		TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:43133498G>A	uc002xme.2	-	7	952	c.818C>T	c.(817-819)TCC>TTC	p.S273F	SERINC3_uc002xmf.1_Missense_Mutation_p.S273F|SERINC3_uc010ggs.1_Missense_Mutation_p.S266F|SERINC3_uc010zwp.1_Missense_Mutation_p.S218F	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	273	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			GGTGATGAGGGAGGACTGCAA	0.478													14	57					0	0	0	0	A	43133498	A	A	43133498	3	1	67	1	0	0	0	0	1	0	0	0	14146	1174	41	2	619	2	SERINC3	20	43133498	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	3341413	43133498	19892022	162	13737											
YWHAB	7529	broad.mit.edu	37	chr20	43530177	43530177	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctcttgttctagggaatGacaatggataaaagtgagct	12	13	11	5	0	2	2	0	2	2	0	2	4	2	4	0	2	2	3	0	2	5	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:43530177G>A	uc002xmt.2	+	3	285	c.3G>A	c.(1-3)ATG>ATA	p.M1I	YWHAB_uc002xmu.2_Missense_Mutation_p.M1I	NM_003404	NP_003395	P31946	1433B_HUMAN	tyrosine 3-monooxygenase/tryptophan	1					activation of MAPKK activity|activation of pro-apoptotic gene products|axon guidance|cytoplasmic sequestering of protein|epidermal growth factor receptor signaling pathway|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|mRNA metabolic process|negative regulation of protein dephosphorylation|nerve growth factor receptor signaling pathway|Ras protein signal transduction	centrosome|cytosol|melanosome|perinuclear region of cytoplasm	histone deacetylase binding|phosphoserine binding|protein domain specific binding			kidney(2)|ovary(1)|breast(1)	4		Myeloproliferative disorder(115;0.0122)				TCTAGGGAATGACAATGGATA	0.473													20	91					0	0	0	0	A	43530177	A	A	43530177	3	1	67	1	0	0	0	0	1	0	0	0	17569	1290	45	2	5	2	YWHAB	20	43530177	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	396679	43530177	19495343	163	13738											
NFATC2	4773	broad.mit.edu	37	chr20	50139752	50139752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacggccgggtagatgtggCgaggcaggccggccttggat	6	6	18	11	4	0	1	0	0	0	1	0	3	0	2	4	7	0	2	4	7	1	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr20:50139752C>T	uc002xwd.2	-	2	1248	c.1028G>A	c.(1027-1029)CGC>CAC	p.R343H	NFATC2_uc002xwc.2_Missense_Mutation_p.R343H|NFATC2_uc010zyv.1_Missense_Mutation_p.R124H|NFATC2_uc010zyw.1_Missense_Mutation_p.R124H|NFATC2_uc010zyx.1_Missense_Mutation_p.R323H|NFATC2_uc010zyy.1_Missense_Mutation_p.R124H|NFATC2_uc010zyz.1_Missense_Mutation_p.R124H|NFATC2_uc002xwe.2_Missense_Mutation_p.R323H	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	343					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GTAGATGTGGCGAGGCAGGCC	0.682													6	149					0	0	0	0	T	50139752	T	T	50139752	3	4	67	1	0	0	0	0	1	0	0	0	10416	768	27	1	1833	1	NFATC2	20	50139752	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	6609575	50139752	12885768	164	13739											
TPTE	7179	broad.mit.edu	37	chr21	10934945	10934945	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taatgtacatactgcatagaTtgtagactcgatagtggttt	12	15	9	5	1	0	2	0	0	0	2	1	3	0	2	0	1	3	4	0	1	6	8			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr21:10934945T>A	uc002yip.1	-	15	1216	c.848A>T	c.(847-849)AAT>ATT	p.N283I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.N265I|TPTE_uc002yir.1_Missense_Mutation_p.N245I|TPTE_uc010gkv.1_Missense_Mutation_p.N145I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	283	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTGCATAGATTGTAGACTCG	0.328													15	237					0	0	0	0	A	10934945	A	A	10934945	3	1	67	1	0	0	0	0	1	0	0	0	16497	1493	52	5	847	5	TPTE	21	10934945	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08		10934945	37194950	165	13740											
SERPIND1	3053	broad.mit.edu	37	chr22	21133858	21133858	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggacctggagaagatattCagtgaagacgacgactacat	14	8	11	8	2	1	4	1	1	0	3	1	8	1	5	1	2	1	0	1	2	4	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chr22:21133858C>T	uc002ztb.1	+	2	325	c.258C>T	c.(256-258)TTC>TTT	p.F86F	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Silent_p.F114F	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	86	2 X 11 AA approximate repeats, Asp/Glu- rich (acidic) (hirudin-like).				blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	AGAAGATATTCAGTGAAGACG	0.527													29	76					0	0	0	0	T	21133858	T	T	21133858	2	4	67	1	0	0	0	0	0	0	0	1	14175	825	29	2		2	SERPIND1	22	21133858	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08		21133858	30170708	166	13741											
TBL1X	6907	broad.mit.edu	37	chrX	9673050	9673050	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagcccctgcccttgatgtgGactggcagaacaacacgacc	10	6	10	15	1	0	2	0	1	0	1	0	4	0	3	4	2	4	1	4	2	2	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:9673050G>A	uc010ndq.2	+	13	1500	c.1132G>A	c.(1132-1134)GAC>AAC	p.D378N	TBL1X_uc004csq.3_Missense_Mutation_p.D327N|TBL1X_uc010ndr.2_Missense_Mutation_p.D327N|TBL1X_uc004csr.2_Missense_Mutation_p.D378N|TBL1X_uc004css.2_Missense_Mutation_p.D329N	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	378	WD 4.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				CCTTGATGTGGACTGGCAGAA	0.527													47	152					0	0	0	0	A	9673050	A	A	9673050	3	1	67	1	0	0	0	0	1	0	0	0	15705	1174	41	2	1170	2	TBL1X	23	9673050	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08		9673050	145597510	167	13742											
MAGEB16	139604	broad.mit.edu	37	chrX	35821252	35821252	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcagtatgcggaagctctGaaagaggaagaagagagagc	15	6	14	6	1	2	5	1	1	2	4	3	8	2	7	0	2	3	2	0	2	5	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:35821252G>C	uc010ngt.1	+	2	1218	c.939G>C	c.(937-939)CTG>CTC	p.L313L		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	313										lung(3)|ovary(2)|breast(1)|skin(1)	7						CGGAAGCTCTGAAAGAGGAAG	0.493													7	27					0	0	0	0	C	35821252	C	C	35821252	2	2	67	1	0	0	0	0	0	0	0	1	9227	1277	45	2		2	MAGEB16	23	35821252	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	26148202	35821252	119449308	168	13743											
ZNF41	7592	broad.mit.edu	37	chrX	47308010	47308010	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagaagccttttccacattCactgcattcataaggttttt	10	15	7	9	0	2	1	2	0	0	1	3	2	3	1	2	2	2	2	2	2	2	7			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:47308010C>G	uc004dhs.3	-	4	1352	c.1285G>C	c.(1285-1287)GAA>CAA	p.E429Q	ZNF41_uc004dhu.3_Missense_Mutation_p.E421Q|ZNF41_uc004dht.3_Missense_Mutation_p.E301Q|ZNF41_uc004dhv.3_Missense_Mutation_p.E397Q|ZNF41_uc004dhw.3_Missense_Mutation_p.E389Q|ZNF41_uc004dhy.3_Missense_Mutation_p.E387Q|ZNF41_uc004dhx.3_Missense_Mutation_p.E387Q|ZNF41_uc011mlm.1_Missense_Mutation_p.E301Q	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	429	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				TTTCCACATTCACTGCATTCA	0.408													35	147					0	0	0	0	G	47308010	G	G	47308010	3	3	67	1	0	0	0	0	1	0	0	0	17956	835	29	2	1184	2	ZNF41	23	47308010	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	11486758	47308010	107962550	169	13744											
FGD1	2245	broad.mit.edu	37	chrX	54492271	54492271	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgcaggatgtctccaatgCgtggatagcggtccctgggg	6	10	15	10	2	2	0	0	0	2	0	4	2	3	2	2	5	3	1	2	5	2	1			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:54492271C>T	uc004dtg.2	-	7	2089	c.1355G>A	c.(1354-1356)CGC>CAC	p.R452H	FGD1_uc011moi.1_Missense_Mutation_p.R210H	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	452	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GTCTCCAATGCGTGGATAGCG	0.557													16	82					0	0	0	0	T	54492271	T	T	54492271	3	4	67	1	0	0	0	0	1	0	0	0	5864	768	27	1	1578	1	FGD1	23	54492271	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	7184261	54492271	100778289	170	13745											
ACRC	93953	broad.mit.edu	37	chrX	70830641	70830641	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggcgctttgccaagatccaGattggcttgaaagtctgcga	9	10	12	10	3	1	3	0	1	1	2	2	4	2	3	2	2	2	2	2	2	2	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:70830641G>A	uc004eae.2	+	11	2223	c.1722G>A	c.(1720-1722)CAG>CAA	p.Q574Q	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	574						nucleus				ovary(3)	3	Renal(35;0.156)					CCAAGATCCAGATTGGCTTGA	0.507													8	33					0	0	0	0	A	70830641	A	A	70830641	2	1	67	1	0	0	0	0	0	0	0	1	171	933	33	2		2	ACRC	23	70830641	Silent	SNP	G	TCGA-CN-5373-01A-01D-1434-08	16338370	70830641	84439919	171	13746											
KIAA2022	340533	broad.mit.edu	37	chrX	73963606	73963607	+	Missense_Mutation	DNP	CT	GG	GG																															ttactttcactaataaaagtCtcgaagtaaccccaatcctg																										TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:73963606_73963607CT>GG	uc004eby.2	-	3	1402_1403	c.785_786AG>CC	c.(784-786)GAG>GCC	p.E262A		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	262					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TAATAAAAGTCTCGAAGTAACC	0.391													10	304					0	0	0	0	GG	73963607	GG	GG	73963606	3	3	67	1	0	0	0	0	1	0	0	0	8308	912	32	2	3772	2	KIAA2022	23	73963606	Missense_Mutation	DNP	CT	TCGA-CN-5373-01A-01D-1434-08	3132965	73963606	81306954	172	13747											
ATP7A	538	broad.mit.edu	37	chrX	77254135	77254135	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caggtcactggcatgacttgCgcttcctgtgtagcaaacat	9	11	10	11	1	1	1	1	1	0	0	2	1	2	1	1	2	3	4	1	2	2	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:77254135C>T	uc004ecx.3	+	5	1657	c.1497C>T	c.(1495-1497)TGC>TGT	p.C499C	ATP7A_uc004ecw.2_Silent_p.C499C	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	499	HMA 5.|Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						GCATGACTTGCGCTTCCTGTG	0.408													71	250					0	0	0	0	T	77254135	T	T	77254135	2	4	67	1	0	0	0	0	0	0	0	1	1192	776	27	1		1	ATP7A	23	77254135	Silent	SNP	C	TCGA-CN-5373-01A-01D-1434-08	3290529	77254135	78016425	173	13748											
SH2D1A	4068	broad.mit.edu	37	chrX	123480565	123480565	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctcctgcttgccactgggCtggatggcagctatttgctg	5	12	13	11	0	0	0	0	0	0	0	1	1	1	1	2	3	5	6	2	3	1	3			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:123480565C>A	uc004euf.3	+	1	418	c.73C>A	c.(73-75)CTG>ATG	p.L25M	SH2D1A_uc004euh.3_Missense_Mutation_p.L25M|SH2D1A_uc004eug.3_RNA|SH2D1A_uc010nqw.2_RNA|SH2D1A_uc004eui.3_RNA|SH2D1A_uc010nqx.2_Intron	NM_002351	NP_002342	O60880	SH21A_HUMAN	SH2 domain protein 1A isoform 1	25	SH2.				cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity				0						TGCCACTGGGCTGGATGGCAG	0.597									X-linked_Lymphoproliferative_syndrome				19	97					2.4624e-09	2.63563e-09	1	0	A	123480565	A	A	123480565	3	1	67	1	0	0	0	0	1	0	0	0	14295	796	28	4	75	4	SH2D1A	23	123480565	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	46226430	123480565	31789995	174	13749											
CXorf48	54967	broad.mit.edu	37	chrX	134305035	134305035	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgctgtgggccctgtcGctctgcagggtcggccgtcc	1	10	15	15	3	1	0	0	0	1	0	4	0	2	0	3	3	3	4	3	3	0	0			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:134305035G>A	uc004eyk.1	-	1	717	c.61C>T	c.(61-63)CGA>TGA	p.R21*	CXorf48_uc004eyl.1_Nonsense_Mutation_p.R21*	NM_001031705	NP_001026875	Q8WUE5	CX048_HUMAN	hypothetical protein LOC54967 isoform 1	21											0	Acute lymphoblastic leukemia(192;0.000127)					GGGCCCTGTCGCTCTGCAGGG	0.642													45	117					0	0	0	0	A	134305035	A	A	134305035	4	1	67	1	0	0	0	0	0	1	0	0	4128	1095	38	1	761	1	CXorf48	23	134305035	Nonsense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	10824470	134305035	20965525	175	13750											
ARHGEF6	9459	broad.mit.edu	37	chrX	135757211	135757211	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcgctggtgcagtaggcttCgatcactttaaggatttgag	8	13	13	7	2	1	1	1	1	0	0	2	3	1	2	0	3	2	4	0	3	2	5			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:135757211C>T	uc004fab.2	-	19	2452	c.1990G>A	c.(1990-1992)GAA>AAA	p.E664K	ARHGEF6_uc011mwd.1_Missense_Mutation_p.E537K|ARHGEF6_uc011mwe.1_Missense_Mutation_p.E510K	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	664					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					CAGTAGGCTTCGATCACTTTA	0.413													16	76					0	0	0	0	T	135757211	T	T	135757211	3	4	67	1	0	0	0	0	1	0	0	0	910	893	31	1	356	1	ARHGEF6	23	135757211	Missense_Mutation	SNP	C	TCGA-CN-5373-01A-01D-1434-08	1452176	135757211	19513349	176	13751											
MAMLD1	10046	broad.mit.edu	37	chrX	149639448	149639448	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctccagcccaggagccacgGagccatttacttttggcaac	9	8	10	14	1	0	0	0	0	0	0	1	2	1	2	4	3	5	2	4	3	2	4			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:149639448G>A	uc004fee.1	+	3	1679	c.1603G>A	c.(1603-1605)GAG>AAG	p.E535K	MAMLD1_uc011mxt.1_Missense_Mutation_p.E497K|MAMLD1_uc011mxu.1_Missense_Mutation_p.E510K|MAMLD1_uc011mxv.1_Missense_Mutation_p.E510K|MAMLD1_uc011mxw.1_Missense_Mutation_p.E462K	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	535					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGCCACGGAGCCATTTAC	0.527													57	164					0	0	0	0	A	149639448	A	A	149639448	3	1	67	1	0	0	0	0	1	0	0	0	9261	1175	41	2	1613	2	MAMLD1	23	149639448	Missense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	13882237	149639448	5631112	177	13752											
PASD1	139135	broad.mit.edu	37	chrX	150844493	150844493	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtttctgaggtaggagtcGagggacctcctgatccacag	10	9	13	9	1	1	2	0	2	1	0	4	5	3	4	3	3	0	2	3	3	2	2			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:150844493G>T	uc004fev.3	+	16	2532	c.2200G>T	c.(2200-2202)GAG>TAG	p.E734*		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	734						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGTAGGAGTCGAGGGACCTCC	0.532													56	261					2.78941e-39	3.1107e-39	1	0	T	150844493	T	T	150844493	4	4	67	1	0	0	0	0	0	1	0	0	11525	1059	37	3	2258	3	PASD1	23	150844493	Nonsense_Mutation	SNP	G	TCGA-CN-5373-01A-01D-1434-08	1205045	150844493	4426067	178	13753											
F8	2157	broad.mit.edu	37	chrX	154194878	154194878	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatcagtaagatcatcatcaTagtcttccgcttcttcatta	12	15	4	10	1	7	1	5	0	2	1	8	1	8	1	1	0	0	2	1	0	4	6			TCGA-CN-5373-01A-01D-1434-08	TCGA-CN-5373-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	00988676-1e9b-4e00-b4aa-a8f86c21b206	9937f05c-99cc-491d-88cf-7483e30546ed	g.chrX:154194878T>C	uc004fmt.2	-	8	1265	c.1094A>G	c.(1093-1095)TAT>TGT	p.Y365C		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	365			Y -> C (in HEMA; mild).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	ATCATCATCATAGTCTTCCGC	0.423													40	165					0	0	0	0	C	154194878	C	C	154194878	3	2	67	1	0	0	0	0	1	0	0	0	5375	1406	49	5	6065	5	F8	23	154194878	Missense_Mutation	SNP	T	TCGA-CN-5373-01A-01D-1434-08	3350385	154194878	1075682	179	13754											
FBXO44	93611	broad.mit.edu	37	chr1	11718444	11718444	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagaaatacttcgttacttCatattagtaagatccgggga	14	12	8	7	2	1	2	1	0	0	2	3	3	2	3	1	2	2	2	1	2	7	7			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:11718444C>T	uc001asm.2	+	3	512	c.386C>T	c.(385-387)TCA>TTA	p.S129L	FBXO44_uc001ask.2_Intron|FBXO44_uc010oaq.1_Missense_Mutation_p.S129L|FBXO44_uc001asl.2_Missense_Mutation_p.S129L|FBXO44_uc001asn.2_Intron|FBXO44_uc010oar.1_Intron|FBXO44_uc010oas.1_Intron	NM_033182	NP_149438	Q9H4M3	FBX44_HUMAN	F-box protein 44 isoform 1	129	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		TTCGTTACTTCATATTAGTAA	0.527													15	135					0	0	0	0	T	11718444	T	T	11718444	3	4	68	1	0	0	0	0	1	0	0	0	5785	838	29	2	392	2	FBXO44	1	11718444	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08		11718444	237532177	1	13755											
PRAMEF11	440560	broad.mit.edu	37	chr1	12887625	12887625	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcacccatgggccatagcttCagaccaaaccatccagaagt	13	6	8	14	0	1	2	1	0	0	2	2	2	2	2	5	1	2	2	5	1	3	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:12887625C>T	uc001auk.2	-	3	428	c.232G>A	c.(232-234)GAA>AAA	p.E78K		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	78											0						GCCATAGCTTCAGACCAAACC	0.473													18	365					0	0	0	0	T	12887625	T	T	12887625	3	4	68	1	0	0	0	0	1	0	0	0	12487	835	29	2	1086	2	PRAMEF11	1	12887625	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	1169181	12887625	236362996	2	13756											
ECE1	1889	broad.mit.edu	37	chr1	21585219	21585219	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgttggagttcttggaatcGgcactgacatagacagagaa	12	10	12	7	1	1	3	0	1	1	2	2	6	1	5	0	3	0	3	0	3	3	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:21585219G>C	uc001bek.2	-	6	804	c.729C>G	c.(727-729)GCC>GCG	p.A243A	ECE1_uc001bem.2_Silent_p.A227A|ECE1_uc001bej.2_Silent_p.A231A|ECE1_uc001bei.2_Silent_p.A240A|ECE1_uc010odl.1_Silent_p.A243A|ECE1_uc009vqa.1_Silent_p.A243A	NM_001397	NP_001388	P42892	ECE1_HUMAN	endothelin converting enzyme 1 isoform 1	243	Extracellular (Potential).				bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			ovary(2)|skin(1)	3		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		TCTTGGAATCGGCACTGACAT	0.572													8	115					0	0	0	0	C	21585219	C	C	21585219	2	2	68	1	0	0	0	0	0	0	0	1	4911	1103	39	3		3	ECE1	1	21585219	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	8697594	21585219	227665402	3	13757											
TMEM200B	399474	broad.mit.edu	37	chr1	29447769	29447769	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtaccccgacgcggggacGggtcccagatttctggctct	7	8	13	13	4	2	1	0	0	2	1	3	3	3	2	3	4	1	2	3	4	2	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:29447769G>C	uc001brn.1	-	2	632	c.572C>G	c.(571-573)CCG>CGG	p.P191R		NM_001003682	NP_001003682	Q69YZ2	T200B_HUMAN	transmembrane protein 200B	191	Pro-rich.					integral to membrane					0		Colorectal(325;3.46e-05)|Breast(348;0.00765)|Lung NSC(340;0.0153)|all_lung(284;0.0173)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;7.32e-08)|COAD - Colon adenocarcinoma(152;4.92e-06)|STAD - Stomach adenocarcinoma(196;0.00618)|BRCA - Breast invasive adenocarcinoma(304;0.0501)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.126)		ACGCGGGGACGGGTCCCAGAT	0.692													14	15					0	0	0	0	C	29447769	C	C	29447769	3	2	68	1	0	0	0	0	1	0	0	0	16190	1116	39	3	355	3	TMEM200B	1	29447769	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	7862550	29447769	219802852	4	13758											
SPATA6	54558	broad.mit.edu	37	chr1	48918776	48918776	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagatagatgtcctctttgtCtttaagcacgactcctgggc	9	13	9	10	1	2	2	0	0	2	2	4	3	4	2	2	1	1	1	2	1	3	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:48918776C>G	uc001crr.1	-	2	244	c.79G>C	c.(79-81)GAC>CAC	p.D27H	SPATA6_uc001crs.1_Missense_Mutation_p.D27H|SPATA6_uc010omv.1_Missense_Mutation_p.D27H|SPATA6_uc001crt.2_5'UTR	NM_019073	NP_061946	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6 precursor	27					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				ovary(1)	1						TCCTCTTTGTCTTTAAGCACG	0.388													49	87					0	0	0	0	G	48918776	G	G	48918776	3	3	68	1	0	0	0	0	1	0	0	0	15079	913	32	2	1435	2	SPATA6	1	48918776	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	19471007	48918776	200331845	5	13759											
FUBP1	8880	broad.mit.edu	37	chr1	78428560	78428560	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatttggtggaggatttctCtgaagttctattcttgcacc	7	16	10	8	0	3	1	0	1	3	0	4	3	3	3	1	3	1	3	1	3	2	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:78428560C>G	uc001dii.2	-	14	1328	c.1239G>C	c.(1237-1239)CAG>CAC	p.Q413H	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Missense_Mutation_p.Q434H	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	413	KH 4.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						GAGGATTTCTCTGAAGTTCTA	0.383													31	242					0	0	0	0	G	78428560	G	G	78428560	3	3	68	1	0	0	0	0	1	0	0	0	6126	912	32	2	723	2	FUBP1	1	78428560	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	29509784	78428560	170822061	6	13760											
AGL	178	broad.mit.edu	37	chr1	100357191	100357191	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggttgcaggctatgttcttCtacctgaagcagatcccacg	8	12	10	11	1	2	2	0	1	2	1	3	2	3	2	2	2	3	5	2	2	3	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:100357191C>T	uc001dsi.1	+	23	3379	c.2979C>T	c.(2977-2979)TTC>TTT	p.F993F	AGL_uc001dsj.1_Silent_p.F993F|AGL_uc001dsk.1_Silent_p.F993F|AGL_uc001dsl.1_Silent_p.F993F|AGL_uc001dsm.1_Silent_p.F977F|AGL_uc001dsn.1_Silent_p.F976F	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	993	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CTATGTTCTTCTACCTGAAGC	0.363													32	205					0	0	0	0	T	100357191	T	T	100357191	2	4	68	1	0	0	0	0	0	0	0	1	384	912	32	2		2	AGL	1	100357191	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	21928631	100357191	148893430	7	13761											
THBS3	7059	broad.mit.edu	37	chr1	155174872	155174872	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcatcctcaaatacgccttCtgtccagtcctaatctccag	9	12	5	15	1	3	0	1	0	2	0	7	0	6	0	5	0	2	1	5	0	3	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:155174872C>T	uc001fix.2	-	3	545	c.522G>A	c.(520-522)CAG>CAA	p.Q174Q	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Silent_p.Q174Q|THBS3_uc001fiz.2_Silent_p.Q174Q|THBS3_uc001fiy.2_5'UTR|THBS3_uc010pfu.1_Intron|THBS3_uc010pfv.1_Intron|THBS3_uc001fja.2_RNA|THBS3_uc009wqj.1_Silent_p.Q136Q	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	174	TSP N-terminal.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AATACGCCTTCTGTCCAGTCC	0.577													21	43					0	0	0	0	T	155174872	T	T	155174872	2	4	68	1	0	0	0	0	0	0	0	1	15921	912	32	2		2	THBS3	1	155174872	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	54817681	155174872	94075749	8	13762											
FCRLA	84824	broad.mit.edu	37	chr1	161677126	161677126	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgctctgggtggcccagatGctactgggtaagtaaaatat	10	11	13	7	0	1	1	0	0	1	1	1	1	1	1	1	3	3	4	1	3	5	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:161677126G>A	uc001gbe.2	+	1	365	c.123G>A	c.(121-123)ATG>ATA	p.M41I	FCRLA_uc001gbd.2_Missense_Mutation_p.M41I|FCRLA_uc001gbf.2_Missense_Mutation_p.M41I|FCRLA_uc001gbg.2_Missense_Mutation_p.M41I|FCRLA_uc009wuo.2_Missense_Mutation_p.M41I|FCRLA_uc009wup.2_Missense_Mutation_p.M41I|FCRLA_uc009wuq.2_Missense_Mutation_p.M41I	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	24					cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			TGGCCCAGATGCTACTGGGTA	0.502													4	120					0	0	0	0	A	161677126	A	A	161677126	3	1	68	1	0	0	0	0	1	0	0	0	5832	1319	46	4	125	4	FCRLA	1	161677126	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	6502254	161677126	87573495	9	13763											
NCF2	4688	broad.mit.edu	37	chr1	183546795	183546795	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agtctatcagctggttccctCgaagctgaatcaaggcttct	9	12	9	11	1	4	1	2	1	2	0	6	2	5	1	1	2	2	4	1	2	4	3	rs137854515		TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:183546795C>G	uc001gqj.3	-	3	580	c.305G>C	c.(304-306)CGA>CCA	p.R102P	NCF2_uc010pod.1_Missense_Mutation_p.R102P|NCF2_uc010poe.1_Missense_Mutation_p.R102P|NCF2_uc001gqk.3_Missense_Mutation_p.R102P	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	102	TPR 2.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						CTGGTTCCCTCGAAGCTGAAT	0.488													24	181					0	0	0	0	G	183546795	G	G	183546795	3	3	68	1	0	0	0	0	1	0	0	0	10271	884	31	3	1327	3	NCF2	1	183546795	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	21869669	183546795	65703826	10	13764											
CACNA1S	779	broad.mit.edu	37	chr1	201016272	201016272	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacaatgtccttcttgggccGatagccataatactcctctt	9	14	6	12	1	2	0	0	0	2	0	4	1	4	0	4	1	3	0	4	1	5	7			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:201016272G>A	uc001gvv.2	-	38	4866	c.4639C>T	c.(4639-4641)CGG>TGG	p.R1547W		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1547	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTCTTGGGCCGATAGCCATAA	0.517													90	205					0	0	0	0	A	201016272	A	A	201016272	3	1	68	1	0	0	0	0	1	0	0	0	2559	1057	37	1	1010	1	CACNA1S	1	201016272	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	17469477	201016272	48234349	11	13765											
NAV1	89796	broad.mit.edu	37	chr1	201777960	201777960	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cacgccgctccctaggcctgGcactcacccattccttcggc	5	8	8	20	3	1	0	1	0	0	0	4	0	3	0	5	3	0	2	5	3	1	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:201777960G>A	uc001gwu.2	+	19	4506	c.4159G>A	c.(4159-4161)GCA>ACA	p.A1387T	NAV1_uc001gwx.2_Missense_Mutation_p.A996T	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1390					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CCTAGGCCTGGCACTCACCCA	0.562													6	304					0	0	0	0	A	201777960	A	A	201777960	3	1	68	1	0	0	0	0	1	0	0	0	10236	1203	42	4	4303	4	NAV1	1	201777960	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	761688	201777960	47472661	12	13766											
KCNH1	3756	broad.mit.edu	37	chr1	211192356	211192356	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaaggtggtatgaaaattGagcacaatgtccaccaaaaa	19	7	8	7	0	0	2	0	2	0	0	1	2	1	2	2	2	1	2	2	2	7	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:211192356G>A	uc001hib.2	-	6	971	c.801C>T	c.(799-801)CTC>CTT	p.L267L	KCNH1_uc001hic.2_Silent_p.L267L	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	267	Helical; Name=Segment S2; (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TATGAAAATTGAGCACAATGT	0.453													21	159					0	0	0	0	A	211192356	A	A	211192356	2	1	68	1	0	0	0	0	0	0	0	1	8070	1277	45	2		2	KCNH1	1	211192356	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	9414396	211192356	38058265	13	13767											
RYR2	6262	broad.mit.edu	37	chr1	237868594	237868594	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttggaaactcatctggacaaAcataatatttactccatcta	15	13	4	9	0	3	0	1	0	2	0	4	2	4	2	1	2	3	0	1	2	6	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr1:237868594A>G	uc001hyl.1	+	67	9651	c.9531A>G	c.(9529-9531)AAA>AAG	p.K3177K	RYR2_uc010pxz.1_Silent_p.K132K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3177					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATCTGGACAAACATAATATTT	0.388													16	17					0	0	0	0	G	237868594	G	G	237868594	2	3	68	1	0	0	0	0	0	0	0	1	13834	40	2	5		5	RYR2	1	237868594	Silent	SNP	A	TCGA-CN-5374-01A-01D-1434-08	26676238	237868594	11382027	14	13768											
NT5C1B	93034	broad.mit.edu	37	chr2	18765901	18765901	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgctcggacagagagttgCggtccagctgggtggaggcg	6	7	19	9	3	0	1	0	0	0	1	2	4	1	3	1	5	3	4	1	5	0	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:18765901C>T	uc002rcz.2	-	5	886	c.782G>A	c.(781-783)CGC>CAC	p.R261H	NT5C1B_uc002rcy.2_Missense_Mutation_p.R261H|NT5C1B_uc010exr.2_Missense_Mutation_p.R203H|NT5C1B_uc010yju.1_Missense_Mutation_p.R201H|NT5C1B_uc002rda.2_Missense_Mutation_p.R201H|NT5C1B_uc010yjv.1_Missense_Mutation_p.R278H|NT5C1B_uc010yjw.1_Missense_Mutation_p.R244H|NT5C1B_uc010exs.2_Missense_Mutation_p.R263H|NT5C1B_uc002rdb.1_Missense_Mutation_p.R53H	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	261					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				CAGAGAGTTGCGGTCCAGCTG	0.652													4	24					0	0	0	0	T	18765901	T	T	18765901	3	4	68	1	0	0	0	0	1	0	0	0	10740	768	27	1	1074	1	NT5C1B	2	18765901	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08		18765901	224433472	15	13769											
ADCY3	109	broad.mit.edu	37	chr2	25042974	25042974	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggaggatgacttgggtttCttctaccacctggagaggga	8	11	14	8	1	2	2	0	1	2	1	3	6	2	5	2	5	1	1	2	5	1	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:25042974C>T	uc002rfs.3	-	21	3461	c.3262G>A	c.(3262-3264)GAA>AAA	p.E1088K	ADCY3_uc002rfr.3_Missense_Mutation_p.E675K|ADCY3_uc010ykm.1_Missense_Mutation_p.E1089K	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	1088	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					ACTTGGGTTTCTTCTACCACC	0.612													8	82					0	0	0	0	T	25042974	T	T	25042974	3	4	68	1	0	0	0	0	1	0	0	0	295	922	32	2	176	2	ADCY3	2	25042974	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	6277073	25042974	218156399	16	13770											
LTBP1	4052	broad.mit.edu	37	chr2	33487804	33487804	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tccaggaaataccttcattgGatcaagagaaaaccaaactt	17	9	6	9	0	2	1	2	0	0	1	3	4	3	3	3	2	3	0	3	2	6	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:33487804G>C	uc002ros.2	+	14	2434	c.2434G>C	c.(2434-2436)GAT>CAT	p.D812H	LTBP1_uc002rot.2_Missense_Mutation_p.D486H|LTBP1_uc002rou.2_Missense_Mutation_p.D486H|LTBP1_uc002rov.2_Missense_Mutation_p.D433H|LTBP1_uc010ymz.1_Missense_Mutation_p.D486H|LTBP1_uc010yna.1_Missense_Mutation_p.D433H	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	812					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ACCTTCATTGGATCAAGAGAA	0.368													11	107					0	0	0	0	C	33487804	C	C	33487804	3	2	68	1	0	0	0	0	1	0	0	0	9123	1174	41	2	2543	2	LTBP1	2	33487804	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	8444830	33487804	209711569	17	13771											
FAM98A	25940	broad.mit.edu	37	chr2	33809952	33809952	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgataattctggctccctCttcctccccagcctcctccc	4	12	6	19	0	2	1	0	1	2	0	7	1	7	1	7	2	1	1	7	2	1	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:33809952C>T	uc002rpa.1	-	8	1522	c.1448G>A	c.(1447-1449)AGA>AAA	p.R483K	FAM98A_uc010yne.1_Missense_Mutation_p.R288K|FAM98A_uc010ynd.1_Missense_Mutation_p.R314K|FAM98A_uc002roz.1_Missense_Mutation_p.R321K	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	484	Gly-rich.									ovary(1)	1	all_hematologic(175;0.115)					CTGGCTCCCTCTTCCTCCCCA	0.363													46	300					0	0	0	0	T	33809952	T	T	33809952	3	4	68	1	0	0	0	0	1	0	0	0	5688	913	32	2	112	2	FAM98A	2	33809952	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	322148	33809952	209389421	18	13772											
C2orf3	6936	broad.mit.edu	37	chr2	75915055	75915055	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacactgctatccataaattCttctacagatttgaaccatg	13	13	4	11	0	2	2	0	1	2	1	3	2	3	2	2	0	3	1	2	0	5	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:75915055C>T	uc002sno.2	-	11	1718	c.1588G>A	c.(1588-1590)GAA>AAA	p.E530K	C2orf3_uc010ffs.2_Missense_Mutation_p.E92K|C2orf3_uc002snn.2_Missense_Mutation_p.E361K|C2orf3_uc010fft.2_Missense_Mutation_p.E205K	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	530					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						TCCATAAATTCTTCTACAGAT	0.318													4	134					0	0	0	0	T	75915055	T	T	75915055	3	4	68	1	0	0	0	0	1	0	0	0	2172	922	32	2	785	2	C2orf3	2	75915055	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	42105103	75915055	167284318	19	13773											
LRRTM1	347730	broad.mit.edu	37	chr2	80530589	80530589	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatctggttggaactcagcGtgagttccttaactcggcgc	7	12	12	10	3	2	2	1	2	1	0	4	3	3	3	1	3	3	2	1	3	2	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:80530589G>A	uc002sok.1	-	2	626	c.356C>T	c.(355-357)ACG>ATG	p.T119M	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	119	LRR 2.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GGAACTCAGCGTGAGTTCCTT	0.582										HNSCC(69;0.2)			58	179					0	0	0	0	A	80530589	A	A	80530589	3	1	68	1	0	0	0	0	1	0	0	0	9089	1145	40	1	1216	1	LRRTM1	2	80530589	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	4615534	80530589	162668784	20	13774											
PDCL3	79031	broad.mit.edu	37	chr2	101188229	101188229	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcagtttattggtcctctGgtgtttggcggcatgaacct	5	15	12	9	1	2	1	1	1	1	0	3	1	3	1	2	4	1	4	2	4	2	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:101188229G>A	uc002tao.2	+	5	658	c.546G>A	c.(544-546)CTG>CTA	p.L182L		NM_024065	NP_076970	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	182					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding				0						TTGGTCCTCTGGTGTTTGGCG	0.493													11	235					0	0	0	0	A	101188229	A	A	101188229	2	1	68	1	0	0	0	0	0	0	0	1	11682	1335	47	4		4	PDCL3	2	101188229	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	20657640	101188229	142011144	21	13775											
MRPS9	64965	broad.mit.edu	37	chr2	105708870	105708870	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtctgcagtatatgcagttCattcggctgctagaaaagtt	10	14	10	7	1	2	1	1	0	1	1	3	1	2	1	0	1	3	7	0	1	5	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:105708870C>T	uc002tcn.3	+	8	731	c.663C>T	c.(661-663)TTC>TTT	p.F221F		NM_182640	NP_872578	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9 precursor	221					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						ATATGCAGTTCATTCGGCTGC	0.353													17	77					0	0	0	0	T	105708870	T	T	105708870	2	4	68	1	0	0	0	0	0	0	0	1	9902	825	29	2		2	MRPS9	2	105708870	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	4520641	105708870	137490503	22	13776											
WDR33	55339	broad.mit.edu	37	chr2	128477169	128477169	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctggagggtgaggtcctctCatctcttgaggcgggtggcc	4	10	16	11	1	2	2	1	2	2	0	5	3	3	3	3	6	0	0	3	6	0	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:128477169C>T	uc002tpg.1	-	16	2613	c.2430G>A	c.(2428-2430)ATG>ATA	p.M810I		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	810					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GAGGTCCTCTCATCTCTTGAG	0.617													12	100					0	0	0	0	T	128477169	T	T	128477169	3	4	68	1	0	0	0	0	1	0	0	0	17355	826	29	2	1608	2	WDR33	2	128477169	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	22768299	128477169	114722204	23	13777											
LRP1B	53353	broad.mit.edu	37	chr2	142888281	142888281	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cccgagagagtgagtaaggcGaggagaaactcggacattgt	13	6	15	7	3	0	3	0	1	0	2	1	8	0	4	1	3	1	1	1	3	2	2	rs139525868		TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:142888281G>C	uc002tvj.1	-	1	990	c.18C>G	c.(16-18)CTC>CTG	p.L6L	LRP1B_uc010fnl.1_Silent_p.L43L	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	6					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGAGTAAGGCGAGGAGAAACT	0.522										TSP Lung(27;0.18)			5	14					0	0	0	0	C	142888281	C	C	142888281	2	2	68	1	0	0	0	0	0	0	0	1	9005	1045	37	3		3	LRP1B	2	142888281	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	14411112	142888281	100311092	24	13778											
GTF3C3	9330	broad.mit.edu	37	chr2	197656160	197656160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagacctctcagagctctggGaagtttactccgaggccttt	8	11	11	11	1	2	2	1	0	2	2	4	5	3	3	3	2	2	2	3	2	2	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:197656160G>A	uc002uts.2	-	4	526	c.436C>T	c.(436-438)CCC>TCC	p.P146S	GTF3C3_uc010zgu.1_Missense_Mutation_p.P146S|GTF3C3_uc002utu.2_Missense_Mutation_p.P146S	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	146						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						AGAGCTCTGGGAAGTTTACTC	0.393													6	109					0	0	0	0	A	197656160	A	A	197656160	3	1	68	1	0	0	0	0	1	0	0	0	6913	1174	41	2	2284	2	GTF3C3	2	197656160	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	54767879	197656160	45543213	25	13779											
FN1	2335	broad.mit.edu	37	chr2	216292957	216292957	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acacttccactctcctcggcCgttgcctgtgcagatgcact	6	11	8	16	2	1	1	0	0	1	1	4	1	2	1	4	1	3	3	4	1	0	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:216292957C>T	uc002vfa.2	-	6	1056	c.790G>A	c.(790-792)GGC>AGC	p.G264S	FN1_uc002vfb.2_Missense_Mutation_p.G264S|FN1_uc002vfc.2_Missense_Mutation_p.G264S|FN1_uc002vfd.2_Missense_Mutation_p.G264S|FN1_uc002vfe.2_Missense_Mutation_p.G264S|FN1_uc002vff.2_Missense_Mutation_p.G264S|FN1_uc002vfg.2_Missense_Mutation_p.G264S|FN1_uc002vfh.2_Missense_Mutation_p.G264S|FN1_uc002vfi.2_Missense_Mutation_p.G264S|FN1_uc002vfj.2_Missense_Mutation_p.G264S|FN1_uc002vfl.2_Missense_Mutation_p.G264S	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	264	Fibrin- and heparin-binding 1.|Fibronectin type-I 5.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTCCTCGGCCGTTGCCTGTG	0.557													43	96					0	0	0	0	T	216292957	T	T	216292957	3	4	68	1	0	0	0	0	1	0	0	0	5994	652	23	1	6840	1	FN1	2	216292957	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	18636797	216292957	26906416	26	13780											
RUFY4	285180	broad.mit.edu	37	chr2	218954013	218954013	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagaggctccagcatctctCttccatggctcccgagtgct	6	10	10	15	1	2	1	0	0	2	1	6	2	5	1	3	2	2	5	3	2	0	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:218954013C>G	uc002vgw.2	+	13	2866	c.1022C>G	c.(1021-1023)TCT>TGT	p.S341C	RUFY4_uc002vgy.1_RNA|RUFY4_uc010fvl.1_Missense_Mutation_p.S341C	NM_198483	NP_940885	Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	514	FYVE-type.						metal ion binding			pancreas(1)	1		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CAGCATCTCTCTTCCATGGCT	0.458													8	53					0	0	0	0	G	218954013	G	G	218954013	3	3	68	1	0	0	0	0	1	0	0	0	13806	913	32	2	1579	2	RUFY4	2	218954013	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	2661056	218954013	24245360	27	13781											
HDLBP	3069	broad.mit.edu	37	chr2	242196114	242196114	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctggggtcatctgggcgtggGatctggattttggttgcagt	4	14	17	6	1	3	0	1	0	2	0	3	2	3	2	0	6	1	2	0	6	0	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr2:242196114G>A	uc002waz.2	-	6	786	c.558C>T	c.(556-558)ATC>ATT	p.I186I	HDLBP_uc002wba.2_Silent_p.I186I|HDLBP_uc002wbb.2_Silent_p.I207I|HDLBP_uc010fzn.1_5'UTR	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	186	KH 1.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CTGGGCGTGGGATCTGGATTT	0.483													6	135					0	0	0	0	A	242196114	A	A	242196114	2	1	68	1	0	0	0	0	0	0	0	1	7064	1164	41	2		2	HDLBP	2	242196114	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	23242101	242196114	1003259	28	13782											
MTMR14	64419	broad.mit.edu	37	chr3	9711137	9711137	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgcagatgatgcctgggCagatgtggaggacgtcacgg	8	7	19	7	2	1	3	1	1	0	2	1	5	1	5	1	5	2	2	1	5	0	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:9711137C>A	uc003brz.2	+	5	639	c.515C>A	c.(514-516)GCA>GAA	p.A172E	MTMR14_uc003bsa.2_Missense_Mutation_p.A172E|MTMR14_uc003bsb.2_Missense_Mutation_p.A172E|MTMR14_uc011ath.1_Intron|MTMR14_uc010hcl.2_Intron|MTMR14_uc003bsc.2_RNA	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	172						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					GATGCCTGGGCAGATGTGGAG	0.612													17	101					2.35188e-11	2.56028e-11	1	0	A	9711137	A	A	9711137	3	1	68	1	0	0	0	0	1	0	0	0	9995	710	25	4	533	4	MTMR14	3	9711137	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08		9711137	188311293	29	13783											
EFHB	151651	broad.mit.edu	37	chr3	19961420	19961420	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tactctttctactccagcagGtggatatctgaagttgaaat	11	14	8	8	0	3	2	0	2	3	0	4	3	4	3	1	2	3	2	1	2	5	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:19961420G>A	uc003cbl.3	-	3	1097	c.901C>T	c.(901-903)CCT>TCT	p.P301S	EFHB_uc003cbm.2_Missense_Mutation_p.P171S	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	301					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						ACTCCAGCAGGTGGATATCTG	0.343													31	159					0	0	0	0	A	19961420	A	A	19961420	3	1	68	1	0	0	0	0	1	0	0	0	4967	1261	44	4	1644	4	EFHB	3	19961420	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	10250283	19961420	178061010	30	13784											
ZCWPW2	152098	broad.mit.edu	37	chr3	28520338	28520338	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaataaaaagaagtggtatAaaagtgcactacaagaagca	22	6	9	4	0	0	3	0	0	0	3	0	3	0	3	0	1	3	3	0	1	11	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:28520338A>G	uc003ceh.2	+	5	694	c.526A>G	c.(526-528)AAA>GAA	p.K176E	ZCWPW2_uc003cei.2_Missense_Mutation_p.K176E|ZCWPW2_uc010hfo.2_Translation_Start_Site	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	176							zinc ion binding			ovary(2)	2						GAAGTGGTATAAAAGTGCACT	0.274													10	81					0	0	0	0	G	28520338	G	G	28520338	3	3	68	1	0	0	0	0	1	0	0	0	17665	363	13	5	536	5	ZCWPW2	3	28520338	Missense_Mutation	SNP	A	TCGA-CN-5374-01A-01D-1434-08	8558918	28520338	169502092	31	13785											
TRANK1	9881	broad.mit.edu	37	chr3	36874112	36874112	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgtggattcccggcggttgCgtgcgctttcattttcaaac	5	14	11	11	4	2	0	2	0	0	0	3	1	3	1	1	3	3	2	1	3	1	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:36874112C>T	uc003cgj.2	-	12	5482	c.5180G>A	c.(5179-5181)CGC>CAC	p.R1727H		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2277					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CCGGCGGTTGCGTGCGCTTTC	0.478													5	112					0	0	0	0	T	36874112	T	T	36874112	3	4	68	1	0	0	0	0	1	0	0	0	16521	768	27	1	1959	1	TRANK1	3	36874112	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	8353774	36874112	161148318	32	13786											
DLEC1	9940	broad.mit.edu	37	chr3	38105339	38105339	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcatcccacagttgtgctGatactccagtgtttctagct	7	16	7	11	0	2	1	1	1	1	0	4	1	4	1	2	0	3	4	2	0	2	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:38105339G>T	uc003cho.1	+	6	1123	c.1102G>T	c.(1102-1104)GAT>TAT	p.D368Y	DLEC1_uc003chp.1_Missense_Mutation_p.D368Y|DLEC1_uc010hgv.1_Missense_Mutation_p.D368Y|DLEC1_uc010hgw.1_Missense_Mutation_p.D67Y|DLEC1_uc003chq.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	368					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CAGTTGTGCTGATACTCCAGT	0.303													33	262					3.03874e-20	3.37929e-20	1	0	T	38105339	T	T	38105339	3	4	68	1	0	0	0	0	1	0	0	0	4574	1290	45	2	1124	2	DLEC1	3	38105339	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1231227	38105339	159917091	33	13787											
ITIH4	3700	broad.mit.edu	37	chr3	52850976	52850976	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgagtcaccaccacgtgttCaggggatgcgtgaacccata	10	7	11	13	3	2	1	2	1	0	0	2	3	2	2	4	2	2	1	4	2	2	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:52850976C>G	uc003dfz.2	-	21	2431	c.2395G>C	c.(2395-2397)GAA>CAA	p.E799Q	ITIH4_uc011bel.1_Missense_Mutation_p.E513Q|ITIH4_uc003dfy.2_Missense_Mutation_p.E594Q|ITIH4_uc011bem.1_Missense_Mutation_p.E804Q|ITIH4_uc011ben.1_Missense_Mutation_p.E769Q	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	799					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		ACCACGTGTTCAGGGGATGCG	0.582													48	296					0	0	0	0	G	52850976	G	G	52850976	3	3	68	1	0	0	0	0	1	0	0	0	7945	835	29	2	413	2	ITIH4	3	52850976	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	14745637	52850976	145171454	34	13788											
POPDC2	64091	broad.mit.edu	37	chr3	119367500	119367500	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgtagctacatgaggtctCagcagtcagagtgacctgag	12	9	12	8	0	2	4	2	3	1	1	3	4	2	4	1	1	3	3	1	1	3	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:119367500C>T	uc003ecx.1	-	3	750	c.616G>A	c.(616-618)GAG>AAG	p.E206K	POPDC2_uc010hqw.1_Missense_Mutation_p.E206K|POPDC2_uc003ecy.1_Missense_Mutation_p.E24K	NM_022135	NP_071418	Q9HBU9	POPD2_HUMAN	popeye protein 2	206						integral to membrane				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.242)		CATGAGGTCTCAGCAGTCAGA	0.473													9	86					0	0	0	0	T	119367500	T	T	119367500	3	4	68	1	0	0	0	0	1	0	0	0	12310	835	29	2	486	2	POPDC2	3	119367500	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	66516524	119367500	78654930	35	13789											
C3orf15	89876	broad.mit.edu	37	chr3	119434506	119434506	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgattatcgggatgctgacGttcaaacagatccatactct	11	12	8	10	2	2	3	1	2	1	1	4	4	3	4	1	1	3	2	1	1	3	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:119434506G>A	uc003ede.3	+	6	675	c.598G>A	c.(598-600)GTT>ATT	p.V200I	C3orf15_uc003edc.2_Missense_Mutation_p.V200I|C3orf15_uc010hqy.1_Missense_Mutation_p.V200I|C3orf15_uc010hqz.2_Missense_Mutation_p.V138I|C3orf15_uc011bjd.1_Missense_Mutation_p.V74I|C3orf15_uc011bje.1_Missense_Mutation_p.V180I|C3orf15_uc010hra.1_5'UTR	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	200						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		GGATGCTGACGTTCAAACAGA	0.463													40	335					0	0	0	0	A	119434506	A	A	119434506	3	1	68	1	0	0	0	0	1	0	0	0	2219	1145	40	1	620	1	C3orf15	3	119434506	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	67006	119434506	78587924	36	13790											
POLQ	10721	broad.mit.edu	37	chr3	121258366	121258366	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agactgcaatatccaatgaaGagaaatgccttgatggagag	16	8	11	6	0	0	5	0	2	0	3	1	7	1	5	2	1	2	1	2	1	5	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:121258366G>C	uc003eee.3	-	4	674	c.545C>G	c.(544-546)TCT>TGT	p.S182C		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	182	Helicase ATP-binding.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		ATCCAATGAAGAGAAATGCCT	0.398								DNA_polymerases_(catalytic_subunits)					6	237					0	0	0	0	C	121258366	C	C	121258366	3	2	68	1	0	0	0	0	1	0	0	0	12263	942	33	2	7335	2	POLQ	3	121258366	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1823860	121258366	76764064	37	13791											
KALRN	8997	broad.mit.edu	37	chr3	124418865	124418865	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgagccctcggagtttgtgCgacttccagaatatggtgag	8	10	14	9	3	0	2	0	1	0	1	2	5	1	3	2	2	2	1	2	2	2	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:124418865C>T	uc003ehg.2	+	56	8108	c.7981C>T	c.(7981-7983)CGA>TGA	p.R2661*	KALRN_uc003ehk.2_Nonsense_Mutation_p.R964*	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2660					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GGAGTTTGTGCGACTTCCAGA	0.597													5	288					0	0	0	0	T	124418865	T	T	124418865	4	4	68	1	0	0	0	0	0	1	0	0	8014	760	27	1	8359	1	KALRN	3	124418865	Nonsense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	3160499	124418865	73603565	38	13792											
TF	7018	broad.mit.edu	37	chr3	133476692	133476692	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacctgctgtttaaggactCtgcccacgggtttttaaaag	9	12	11	9	1	1	0	0	0	1	0	1	2	1	2	2	3	2	3	2	3	3	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:133476692C>G	uc003epu.1	+	13	2678	c.950C>G	c.(949-951)TCT>TGT	p.S317C	TF_uc011blt.1_Missense_Mutation_p.S190C|TF_uc003epw.1_Intron|TF_uc003epv.1_Missense_Mutation_p.S317C	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	317	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	TTTAAGGACTCTGCCCACGGG	0.458													20	191					0	0	0	0	G	133476692	G	G	133476692	3	3	68	1	0	0	0	0	1	0	0	0	15851	913	32	2	980	2	TF	3	133476692	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	9057827	133476692	64545738	39	13793											
PLSCR2	57047	broad.mit.edu	37	chr3	146171886	146171886	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttaattgtaaactttgttAgacatgggtgccaggtctga	10	16	10	5	0	1	2	0	1	1	1	1	2	1	2	1	2	2	2	1	2	4	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:146171886A>G	uc003evv.1	-	6	719	c.386T>C	c.(385-387)CTA>CCA	p.L129P	PLSCR2_uc003evw.1_Missense_Mutation_p.L198P	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	129	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						AAACTTTGTTAGACATGGGTG	0.373													12	147					0	0	0	0	G	146171886	G	G	146171886	3	3	68	1	0	0	0	0	1	0	0	0	12165	420	15	5	300	5	PLSCR2	3	146171886	Missense_Mutation	SNP	A	TCGA-CN-5374-01A-01D-1434-08	12695194	146171886	51850544	40	13794											
MME	4311	broad.mit.edu	37	chr3	154886339	154886339	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggactcaacagtctgcaagTaactttaaggagcaatccca	14	9	8	10	0	2	0	1	0	1	0	3	2	3	2	1	2	4	3	1	2	5	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:154886339T>G	uc010hvr.1	+	19	2050	c.1839T>G	c.(1837-1839)AGT>AGG	p.S613R	MME_uc003fab.1_Missense_Mutation_p.S613R|MME_uc003fac.1_Missense_Mutation_p.S613R|MME_uc003fad.1_Missense_Mutation_p.S613R|MME_uc003fae.1_Missense_Mutation_p.S613R	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	613	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	AGTCTGCAAGTAACTTTAAGG	0.408													50	156					0	0	0	0	G	154886339	G	G	154886339	3	3	68	1	0	0	0	0	1	0	0	0	9698	1635	57	5	1909	5	MME	3	154886339	Missense_Mutation	SNP	T	TCGA-CN-5374-01A-01D-1434-08	8714453	154886339	43136091	41	13795											
PLCH1	23007	broad.mit.edu	37	chr3	155203166	155203166	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagagagttttcttttccttCaatgtcttttgctgtttcag	6	21	7	7	0	4	1	2	0	2	1	5	2	5	1	1	0	1	3	1	0	2	9			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr3:155203166C>T	uc011bok.1	-	22	3254	c.2977G>A	c.(2977-2979)GAA>AAA	p.E993K	PLCH1_uc011boj.1_Missense_Mutation_p.E993K|PLCH1_uc011bol.1_Missense_Mutation_p.E955K	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	993					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCTTTTCCTTCAATGTCTTTT	0.453													13	198					0	0	0	0	T	155203166	T	T	155203166	3	4	68	1	0	0	0	0	1	0	0	0	12092	835	29	2	2127	2	PLCH1	3	155203166	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	316827	155203166	42819264	42	13796											
TACC3	10460	broad.mit.edu	37	chr4	1730363	1730363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgactgggacaaaatggatGacccaaacttcatcccgttc	12	9	8	12	2	1	1	1	1	0	0	4	4	2	3	2	2	1	1	2	2	3	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr4:1730363G>A	uc003gdo.2	+	4	1342	c.1234G>A	c.(1234-1236)GAC>AAC	p.D412N	TACC3_uc010ibz.2_Missense_Mutation_p.D412N|TACC3_uc003gdp.2_Intron|TACC3_uc010ica.2_5'Flank	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	412						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CAAAATGGATGACCCAAACTT	0.632													25	95					0	0	0	0	A	1730363	A	A	1730363	3	1	68	1	0	0	0	0	1	0	0	0	15569	1290	45	2	1244	2	TACC3	4	1730363	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08		1730363	189423913	43	13797											
JAKMIP1	152789	broad.mit.edu	37	chr4	6064157	6064157	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgcaggtcagcctcctctCgggctgtggccttcacataa	7	9	11	14	2	3	0	2	0	1	0	5	0	4	0	3	3	2	2	3	3	1	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr4:6064157C>T	uc003giu.3	-	10	1718	c.1442G>A	c.(1441-1443)CGA>CAA	p.R481Q	JAKMIP1_uc010idb.1_Missense_Mutation_p.R481Q|JAKMIP1_uc010idc.1_Missense_Mutation_p.R296Q|JAKMIP1_uc010idd.1_Missense_Mutation_p.R481Q|JAKMIP1_uc011bwc.1_Missense_Mutation_p.R316Q|JAKMIP1_uc003giv.3_Missense_Mutation_p.R481Q|JAKMIP1_uc010ide.2_Missense_Mutation_p.R481Q	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	481	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						AGCCTCCTCTCGGGCTGTGGC	0.473													17	71					0	0	0	0	T	6064157	T	T	6064157	3	4	68	1	0	0	0	0	1	0	0	0	7979	884	31	1	1176	1	JAKMIP1	4	6064157	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	4333794	6064157	185090119	44	13798											
GUCY1A3	2982	broad.mit.edu	37	chr4	156638419	156638419	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaagatgatggagctctctGatgaagttatgtctccccat	10	13	10	8	0	2	5	0	4	2	1	4	6	2	6	2	1	1	2	2	1	3	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr4:156638419G>C	uc003iov.2	+	9	2217	c.1681G>C	c.(1681-1683)GAT>CAT	p.D561H	GUCY1A3_uc010iqc.2_Missense_Mutation_p.D561H|GUCY1A3_uc003iow.2_Missense_Mutation_p.D561H|GUCY1A3_uc010iqd.2_Missense_Mutation_p.D560H|GUCY1A3_uc003iox.2_Missense_Mutation_p.D561H|GUCY1A3_uc003ioz.2_Missense_Mutation_p.D326H|GUCY1A3_uc003ioy.2_Missense_Mutation_p.D561H|GUCY1A3_uc010iqe.2_Missense_Mutation_p.D326H|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.D561H	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	561	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		GGAGCTCTCTGATGAAGTTAT	0.438													18	70					0	0	0	0	C	156638419	C	C	156638419	3	2	68	1	0	0	0	0	1	0	0	0	6933	1290	45	2	1718	2	GUCY1A3	4	156638419	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	150574262	156638419	34515857	45	13799											
NPY5R	4889	broad.mit.edu	37	chr4	164272702	164272702	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcttaatccaattctatatgGgtttcttaataatgggatta	12	18	6	5	0	3	0	0	0	3	0	4	1	4	1	1	2	0	1	1	2	7	8			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr4:164272702G>T	uc003iqn.2	+	4	1459	c.1277G>T	c.(1276-1278)GGG>GTG	p.G426V		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	426	Helical; Name=7; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				ATTCTATATGGGTTTCTTAAT	0.333													24	131					1.10923e-09	1.18748e-09	1	0	T	164272702	T	T	164272702	3	4	68	1	0	0	0	0	1	0	0	0	10664	1232	43	4	1279	4	NPY5R	4	164272702	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	7634283	164272702	26881574	46	13800											
TRIML2	205860	broad.mit.edu	37	chr4	189026443	189026443	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcaacatcacagaacagcCgtgttggttccaggtgtgtt	9	11	12	9	1	2	1	2	0	0	1	3	1	3	1	2	3	3	3	2	3	2	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr4:189026443C>T	uc003izl.2	-						TRIML2_uc011cle.1_Missense_Mutation_p.R27Q|TRIML2_uc011clf.1_Missense_Mutation_p.R27Q	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2								ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		ACAGAACAGCCGTGTTGGTTC	0.502													61	123					0	0	0	0	T	189026443	T	T	189026443	1	4	68	0	1	0	0	0	0	0	0	0	16618	667	23	1		1	TRIML2	4	189026443	5'Flank	SNP	C	TCGA-CN-5374-01A-01D-1434-08	24753741	189026443	2127833	47	13801											
IRX1	79192	broad.mit.edu	37	chr5	3599879	3599879	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctcgccgctggcagcagccGacgttctcaagccccaggac	7	5	12	17	4	1	0	1	0	1	0	3	2	1	1	4	2	3	5	4	2	1	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr5:3599879G>A	uc003jde.2	+	2	869	c.817G>A	c.(817-819)GAC>AAC	p.D273N		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	273						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GGCAGCAGCCGACGTTCTCAA	0.726													8	8					0	0	0	0	A	3599879	A	A	3599879	3	1	68	1	0	0	0	0	1	0	0	0	7882	1058	37	1	823	1	IRX1	5	3599879	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08		3599879	177315381	48	13802											
NPR3	4883	broad.mit.edu	37	chr5	32783030	32783030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttattttggaaaagaaggtcGttttgaaatgcggccgaatg	12	13	12	4	3	0	2	0	1	0	1	1	4	0	3	1	3	1	1	1	3	6	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr5:32783030G>A	uc003jhv.2	+	6	1540	c.1322G>A	c.(1321-1323)CGT>CAT	p.R441H	NPR3_uc010iuo.2_Missense_Mutation_p.R225H|NPR3_uc011cnz.1_Missense_Mutation_p.R225H|NPR3_uc003jhu.2_Missense_Mutation_p.R441H	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	441	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	AAAGAAGGTCGTTTTGAAATG	0.398													9	25					0	0	0	0	A	32783030	A	A	32783030	3	1	68	1	0	0	0	0	1	0	0	0	10650	1145	40	1	1344	1	NPR3	5	32783030	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	29183151	32783030	148132230	49	13803											
SPEF2	79925	broad.mit.edu	37	chr5	35705876	35705876	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaaaaagtaaaagaaatTcttacgactgaaatagcaaa	21	9	7	4	1	1	3	0	2	1	1	1	4	1	3	0	0	2	2	0	0	9	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr5:35705876T>C	uc003jjo.2	+	18	2742	c.2631T>C	c.(2629-2631)ATT>ATC	p.I877I	SPEF2_uc003jjq.3_Silent_p.I872I|SPEF2_uc003jjp.1_Silent_p.I363I	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	877	Potential.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TAAAAGAAATTCTTACGACTG	0.279													3	73					0	0	0	0	C	35705876	C	C	35705876	2	2	68	1	0	0	0	0	0	0	0	1	15101	1771	62	5		5	SPEF2	5	35705876	Silent	SNP	T	TCGA-CN-5374-01A-01D-1434-08	2922846	35705876	145209384	50	13804											
ESM1	11082	broad.mit.edu	37	chr5	54275189	54275189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atttaaccatttcctcattaCgggagacccggcagcattct	10	12	7	12	2	2	1	1	0	1	1	3	2	3	1	3	2	3	2	3	2	2	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr5:54275189C>T	uc003jpk.2	-	3	595	c.526G>A	c.(526-528)GTA>ATA	p.V176I	ESM1_uc010ivt.2_Missense_Mutation_p.V126I	NM_007036	NP_008967	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1 isoform a	176					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			TTCCTCATTACGGGAGACCCG	0.438													35	196					0	0	0	0	T	54275189	T	T	54275189	3	4	68	1	0	0	0	0	1	0	0	0	5276	536	19	1	32	1	ESM1	5	54275189	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	18569313	54275189	126640071	51	13805											
MAN2A1	4124	broad.mit.edu	37	chr5	109152986	109152986	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgcaggtaccttgtggtCtataatcctttagaacaaga	11	15	8	7	0	1	2	0	0	1	2	2	2	2	2	2	2	3	2	2	2	6	8			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr5:109152986C>G	uc003kou.1	+	13	2919	c.1956C>G	c.(1954-1956)GTC>GTG	p.V652V		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	652	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		ACCTTGTGGTCTATAATCCTT	0.338													24	179					0	0	0	0	G	109152986	G	G	109152986	2	3	68	1	0	0	0	0	0	0	0	1	9267	900	32	2		2	MAN2A1	5	109152986	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	54877797	109152986	71762274	52	13806											
PCDHB11	56125	broad.mit.edu	37	chr5	140579531	140579531	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgagagaactgtcctcaCggggggctcgggtggtctct	6	9	17	9	2	2	2	1	1	1	1	5	3	3	2	1	6	1	1	1	6	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr5:140579531C>T	uc003liy.2	+	1	184	c.184C>T	c.(184-186)CGG>TGG	p.R62W	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	62	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTGTCCTCACGGGGGGCTCG	0.507													7	185					0	0	0	0	T	140579531	T	T	140579531	3	4	68	1	0	0	0	0	1	0	0	0	11590	527	19	1	186	1	PCDHB11	5	140579531	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	31426545	140579531	40335729	53	13807											
PCDH12	51294	broad.mit.edu	37	chr5	141336463	141336463	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttgcctgaacatccacctcGtaggcagggttcttttcata	8	13	8	12	1	2	1	1	1	1	0	4	1	3	1	3	2	2	3	3	2	3	6	rs148884293	by1000genomes	TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr5:141336463G>A	uc003llx.2	-	1	2165	c.954C>T	c.(952-954)TAC>TAT	p.Y318Y		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	318	Extracellular (Potential).|Cadherin 3.				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCCACCTCGTAGGCAGGGT	0.517													16	98					0	0	0	0	A	141336463	A	A	141336463	2	1	68	1	0	0	0	0	0	0	0	1	11564	1140	40	1		1	PCDH12	5	141336463	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	756932	141336463	39578797	54	13808											
ANXA6	309	broad.mit.edu	37	chr5	150514043	150514043	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtcatcctcctccctggttCcctgggcagaaagacaaaga	10	8	9	14	1	1	3	1	0	0	3	5	3	5	3	4	2	0	2	4	2	2	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr5:150514043C>A	uc003ltl.1	-	8	643	c.491G>T	c.(490-492)GGA>GTA	p.G164V	ANXA6_uc011dcp.1_Missense_Mutation_p.G132V|ANXA6_uc003ltm.1_Missense_Mutation_p.G164V|ANXA6_uc003ltn.1_Intron|ANXA6_uc003lto.1_Intron	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	164						melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding				0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCCCTGGTTCCCTGGGCAGA	0.542													5	213					0.00116845	0.00120103	1	0	A	150514043	A	A	150514043	3	1	68	1	0	0	0	0	1	0	0	0	722	869	30	2	1606	2	ANXA6	5	150514043	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	9177580	150514043	30401217	55	13809											
ODZ2	57451	broad.mit.edu	37	chr5	167645855	167645855	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcacctgctcatgcctgaCaaccagatcatcaccctcac	10	8	5	18	1	5	2	5	1	0	1	5	2	5	2	4	0	3	1	4	0	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr5:167645855C>G	uc010jjd.2	+	23	4932	c.4932C>G	c.(4930-4932)GAC>GAG	p.D1644E	ODZ2_uc003lzr.3_Missense_Mutation_p.D1414E|ODZ2_uc003lzt.3_Missense_Mutation_p.D1017E|ODZ2_uc010jje.2_Missense_Mutation_p.D908E	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TCATGCCTGACAACCAGATCA	0.522													27	243					0	0	0	0	G	167645855	G	G	167645855	3	3	68	1	0	0	0	0	1	0	0	0	10889	477	17	4	5022	4	ODZ2	5	167645855	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	17131812	167645855	13269405	56	13810											
FGFR4	2264	broad.mit.edu	37	chr5	176524631	176524631	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcagccacgaccccctgcCattgggatccagctccttcc	6	9	7	19	1	1	0	1	0	0	0	4	2	4	1	7	1	3	1	7	1	0	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr5:176524631C>T	uc003mfl.2	+	18	2530	c.2363C>T	c.(2362-2364)CCA>CTA	p.P788L	FGFR4_uc003mfm.2_Missense_Mutation_p.P788L|FGFR4_uc011dfu.1_Missense_Mutation_p.P720L|FGFR4_uc003mfo.2_Missense_Mutation_p.P748L	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	788	Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GACCCCCTGCCATTGGGATCC	0.642										TSP Lung(9;0.080)			17	82					0	0	0	0	T	176524631	T	T	176524631	3	4	68	1	0	0	0	0	1	0	0	0	5900	594	21	4	2499	4	FGFR4	5	176524631	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	8878776	176524631	4390629	57	13811											
RREB1	6239	broad.mit.edu	37	chr6	7229784	7229784	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctcggctccccctcagatCagtcttccgcccttctccaa	5	10	6	20	2	4	1	2	0	2	1	8	1	6	1	6	1	0	1	6	1	1	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:7229784C>T	uc003mxc.2	+	10	1842	c.1452C>T	c.(1450-1452)ATC>ATT	p.I484I	RREB1_uc003mxb.2_Silent_p.I484I|RREB1_uc010jnx.2_Silent_p.I484I	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	484	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CCCCTCAGATCAGTCTTCCGC	0.617													11	474					0	0	0	0	T	7229784	T	T	7229784	2	4	68	1	0	0	0	0	0	0	0	1	13744	816	29	2		2	RREB1	6	7229784	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08		7229784	163885283	58	13812											
GCNT2	2651	broad.mit.edu	37	chr6	10621646	10621646	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagagctataaagtggagtGacatggaagacagacacgga	16	6	13	6	1	1	4	1	1	0	3	1	7	1	7	0	3	1	1	0	3	4	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:10621646G>A	uc010joo.2	+	4	1539	c.988G>A	c.(988-990)GAC>AAC	p.D330N	GCNT2_uc010jol.2_Missense_Mutation_p.D44N|GCNT2_uc010jom.2_RNA|GCNT2_uc010jop.2_RNA|GCNT2_uc003mza.2_RNA|GCNT2_uc003mzc.3_Missense_Mutation_p.D329N|GCNT2_uc003mzd.2_Missense_Mutation_p.D328N|GCNT2_uc003mze.2_Missense_Mutation_p.D330N	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	330	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AAAGTGGAGTGACATGGAAGA	0.507													6	48					0	0	0	0	A	10621646	A	A	10621646	3	1	68	1	0	0	0	0	1	0	0	0	6336	1290	45	2	2846	2	GCNT2	6	10621646	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	3391862	10621646	160493421	59	13813											
KIF13A	63971	broad.mit.edu	37	chr6	17764821	17764821	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaactctttgtttgaggaCggcctgaaatcatgcacaag	11	11	10	9	1	3	2	2	2	1	0	3	3	3	3	1	2	2	2	1	2	3	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:17764821C>T	uc003ncg.3	-	39	5043	c.4938G>A	c.(4936-4938)CCG>CCA	p.P1646P	KIF13A_uc003ncf.2_Silent_p.P1598P|KIF13A_uc003nch.3_Silent_p.P1611P|KIF13A_uc003nci.3_Silent_p.P1598P|KIF13A_uc003nce.1_Silent_p.P197P	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1646					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TGTTTGAGGACGGCCTGAAAT	0.507													10	72					0	0	0	0	T	17764821	T	T	17764821	2	4	68	1	0	0	0	0	0	0	0	1	8313	523	19	1		1	KIF13A	6	17764821	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	7143175	17764821	153350246	60	13814											
KIF13A	63971	broad.mit.edu	37	chr6	17797042	17797042	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaattcttctgttacattcaCcacatagtcctgggataagt	12	14	6	9	0	3	0	1	0	2	0	4	1	4	1	2	1	1	1	2	1	4	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:17797042C>A	uc003ncg.3	-	23	2905	c.2800G>T	c.(2800-2802)GTG>TTG	p.V934L	KIF13A_uc003ncf.2_Missense_Mutation_p.V934L|KIF13A_uc003nch.3_Missense_Mutation_p.V934L|KIF13A_uc003nci.3_Missense_Mutation_p.V934L	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	934					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GTTACATTCACCACATAGTCC	0.423													12	66					0.00010058	0.000104636	1	0	A	17797042	A	A	17797042	3	1	68	1	0	0	0	0	1	0	0	0	8313	507	18	4	2710	4	KIF13A	6	17797042	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	32221	17797042	153318025	61	13815											
HIST1H3I	8354	broad.mit.edu	37	chr6	27839826	27839826	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcctcctgcagcgccatcaCcgccgagctctggaagcgca	8	5	11	17	4	2	0	1	0	1	0	3	2	3	1	5	1	5	3	5	1	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:27839826C>A	uc003njy.2	-	1	274	c.268G>T	c.(268-270)GTG>TTG	p.V90L		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	90					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						AGCGCCATCACCGCCGAGCTC	0.567													9	189					1.12685e-05	1.18664e-05	1	0	A	27839826	A	A	27839826	3	1	68	1	0	0	0	0	1	0	0	0	7202	507	18	4	146	4	HIST1H3I	6	27839826	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	10042784	27839826	143275241	62	13816											
ZNF165	7718	broad.mit.edu	37	chr6	28056699	28056699	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtgaccagagcttcaaatgGaactcagattttattaacca	14	12	7	8	0	2	3	2	1	0	2	2	4	2	4	2	1	3	1	2	1	4	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:28056699G>C	uc003nkg.2	+	5	1993	c.909G>C	c.(907-909)TGG>TGC	p.W303C	ZNF165_uc003nkh.2_Missense_Mutation_p.W303C|ZNF165_uc003nki.3_Missense_Mutation_p.W303C|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	303	C2H2-type 1; degenerate.				viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCTTCAAATGGAACTCAGATT	0.363													22	44					0	0	0	0	C	28056699	C	C	28056699	3	2	68	1	0	0	0	0	1	0	0	0	17807	1183	41	2	919	2	ZNF165	6	28056699	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	216873	28056699	143058368	63	13817											
HLA-DRB5	3127	broad.mit.edu	37	chr6	32557568	32557569	+	5'Flank	INS	-	AT	AT																															gagaagcaggcaagtctcacINStcagggagaactatgaaccc																								rs17204758		TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:32557568_32557569insAT	uc003obk.3	-						HLA-DRB1_uc003obp.3_5'Flank	NM_002125	NP_002116	Q30154	DRB5_HUMAN	major histocompatibility complex, class II, DR						antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						GCAAGTCTCACTCAGGGAGAAC	0.54													---	---	---								AT	32557569	AT	AT	32557568	6	5	68	0	1	1	1	0	0	0	0	0	7248	580	20	0		0	HLA-DRB5	6	32557568	5'Flank	INS	-	TCGA-CN-5374-01A-01D-1434-08	4500869	32557568	138557499	64	13818											
CUL7	9820	broad.mit.edu	37	chr6	43006428	43006428	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagactctccacagagacCgccttcagagaacagatggg	13	5	11	12	1	2	4	1	0	1	4	3	6	2	4	3	1	2	1	3	1	1	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:43006428C>T	uc003otq.2	-	24	4746	c.4443G>A	c.(4441-4443)GCG>GCA	p.A1481A	CUL7_uc010jyg.2_Silent_p.A760A|CUL7_uc011dvb.1_Silent_p.A1565A|CUL7_uc010jyh.2_Silent_p.A474A|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1481					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCACAGAGACCGCCTTCAGAG	0.577													19	149					0	0	0	0	T	43006428	T	T	43006428	2	4	68	1	0	0	0	0	0	0	0	1	4077	639	23	1		1	CUL7	6	43006428	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	10448860	43006428	128108639	65	13819											
GTPBP2	54676	broad.mit.edu	37	chr6	43590532	43590532	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	accagctggtccccctcacgGcaaatcccactgcagcccag	9	5	8	19	1	1	0	1	0	0	0	3	0	3	0	5	2	3	3	5	2	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:43590532G>A	uc003ovs.2	-	10	1342	c.1305C>T	c.(1303-1305)TGC>TGT	p.C435C	GTPBP2_uc010jyv.2_Silent_p.C347C|GTPBP2_uc003ovt.1_Silent_p.C435C	NM_019096	NP_061969	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	435							GTP binding|GTPase activity			liver(1)|skin(1)	2	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			CCCCCTCACGGCAAATCCCAC	0.597													3	46					0	0	0	0	A	43590532	A	A	43590532	2	1	68	1	0	0	0	0	0	0	0	1	6919	1195	42	4		4	GTPBP2	6	43590532	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	584104	43590532	127524535	66	13820											
TDRD6	221400	broad.mit.edu	37	chr6	46657374	46657374	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaaaatccttctgagttttgGattaggttgaggaaacacaa	15	12	9	5	0	1	2	0	2	1	0	2	4	2	4	1	3	1	2	1	3	5	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:46657374G>A	uc003oyj.2	+	1	1509	c.1509G>A	c.(1507-1509)TGG>TGA	p.W503*	TDRD6_uc010jze.2_Nonsense_Mutation_p.W497*	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	503					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CTGAGTTTTGGATTAGGTTGA	0.408													24	181					0	0	0	0	A	46657374	A	A	46657374	4	1	68	1	0	0	0	0	0	1	0	0	15800	1183	41	2	1511	2	TDRD6	6	46657374	Nonsense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	3066842	46657374	124457693	67	13821											
MAP3K7	6885	broad.mit.edu	37	chr6	91257806	91257806	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaacaattttgattctaagCgcttaatagtatcatttgtg	12	17	6	6	1	3	1	2	1	1	0	3	1	3	1	0	0	2	2	0	0	6	8			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:91257806C>T	uc003pnz.1	-	10	1202	c.1040G>A	c.(1039-1041)CGC>CAC	p.R347H	MAP3K7_uc003poa.1_Missense_Mutation_p.R347H|MAP3K7_uc003pob.1_Missense_Mutation_p.R347H|MAP3K7_uc003poc.1_Missense_Mutation_p.R347H	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	347					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		TGATTCTAAGCGCTTAATAGT	0.343													5	84					0	0	0	0	T	91257806	T	T	91257806	3	4	68	1	0	0	0	0	1	0	0	0	9308	768	27	1	812	1	MAP3K7	6	91257806	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	44600432	91257806	79857261	68	13822											
MANEA	79694	broad.mit.edu	37	chr6	96054094	96054094	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcttaatttctatcacctCttttaatgagtggcatgaag	11	15	7	8	0	3	2	1	2	2	0	3	2	3	2	1	1	1	2	1	1	4	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:96054094C>G	uc003poo.1	+	5	1342	c.1202C>G	c.(1201-1203)TCT>TGT	p.S401C		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	401	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		TCTATCACCTCTTTTAATGAG	0.428													10	104					0	0	0	0	G	96054094	G	G	96054094	3	3	68	1	0	0	0	0	1	0	0	0	9274	913	32	2	1216	2	MANEA	6	96054094	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	4796288	96054094	75060973	69	13823											
AIM1	202	broad.mit.edu	37	chr6	106973015	106973015	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catctgattgcagacacttaGaggaagtgtccaaaataaac	16	9	8	8	0	1	3	0	1	1	2	2	4	2	4	1	1	2	1	1	1	6	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:106973015G>C	uc003prh.2	+	3	3516	c.3029G>C	c.(3028-3030)AGA>ACA	p.R1010T		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1010							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CAGACACTTAGAGGAAGTGTC	0.373													7	169					0	0	0	0	C	106973015	C	C	106973015	3	2	68	1	0	0	0	0	1	0	0	0	430	942	33	2	3039	2	AIM1	6	106973015	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	10918921	106973015	64142052	70	13824											
SOBP	55084	broad.mit.edu	37	chr6	107955074	107955074	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacactgccaactgctctgtCactaaaatccccacgccagt	11	8	6	16	1	2	0	1	0	1	0	3	1	3	0	4	0	3	1	4	0	3	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:107955074C>T	uc003prx.2	+	6	1530	c.1026C>T	c.(1024-1026)GTC>GTT	p.V342V		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	342							metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		ACTGCTCTGTCACTAAAATCC	0.642													22	123					0	0	0	0	T	107955074	T	T	107955074	2	4	68	1	0	0	0	0	0	0	0	1	14976	813	29	2		2	SOBP	6	107955074	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	982059	107955074	63159993	71	13825											
UTRN	7402	broad.mit.edu	37	chr6	145118996	145118996	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaataagtgtgaaagagtttAtagattggatgcatttggaa	16	13	11	1	0	0	3	0	1	0	2	0	5	0	5	0	2	1	2	0	2	6	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:145118996A>C	uc003qkt.2	+	63	9207	c.9115A>C	c.(9115-9117)ATA>CTA	p.I3039L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	3039	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GAAAGAGTTTATAGATTGGAT	0.378													14	89					0	0	0	0	C	145118996	C	C	145118996	3	2	68	1	0	0	0	0	1	0	0	0	17171	449	16	5	9365	5	UTRN	6	145118996	Missense_Mutation	SNP	A	TCGA-CN-5374-01A-01D-1434-08	37163922	145118996	25996071	72	13826											
RMND1	55005	broad.mit.edu	37	chr6	151766520	151766520	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttagtggtctcttcacctGtgggaagtcttgttttggaa	6	18	11	6	0	3	0	1	0	2	0	4	2	3	2	1	3	0	1	1	3	3	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:151766520G>A	uc003qoi.2	-	2	607	c.427C>T	c.(427-429)CAG>TAG	p.Q143*	RMND1_uc011eeq.1_5'Flank|RMND1_uc003qoj.2_Nonsense_Mutation_p.Q143*|RMND1_uc011eer.1_Nonsense_Mutation_p.Q143*	NM_017909	NP_060379	Q9NWS8	RMND1_HUMAN	required for meiotic nuclear division 1 homolog	143											0		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.146)	OV - Ovarian serous cystadenocarcinoma(155;6.8e-11)		CTCTTCACCTGTGGGAAGTCT	0.438													54	114					0	0	0	0	A	151766520	A	A	151766520	4	1	68	1	0	0	0	0	0	1	0	0	13461	1386	48	4	966	4	RMND1	6	151766520	Nonsense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	6647524	151766520	19348547	73	13827											
RBM16	22828	broad.mit.edu	37	chr6	155131214	155131214	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgtaaacacagaaagcgatCacgctcccgctcaagagaaa	16	4	9	12	4	2	2	2	0	0	2	3	4	3	2	1	0	2	3	1	0	5	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:155131214C>G	uc003qqa.2	+	13	1524	c.1292C>G	c.(1291-1293)TCA>TGA	p.S431*	RBM16_uc011efj.1_Nonsense_Mutation_p.S497*|RBM16_uc011efk.1_Nonsense_Mutation_p.S476*|RBM16_uc003qpz.2_Nonsense_Mutation_p.S431*|RBM16_uc010kji.2_Nonsense_Mutation_p.S452*	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	431	Arg-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		AGAAAGCGATCACGCTCCCGC	0.413													34	210					0	0	0	0	G	155131214	G	G	155131214	4	3	68	1	0	0	0	0	0	1	0	0	13183	838	29	2	1338	2	RBM16	6	155131214	Nonsense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	3364694	155131214	15983853	74	13828											
PDE10A	10846	broad.mit.edu	37	chr6	165746557	165746557	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgagccacggatggggatGaaatccaggttgcagtctcc	9	9	13	10	1	2	2	0	2	2	0	4	4	3	4	3	4	2	2	3	4	1	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:165746557G>A	uc003qun.2	-	23	2538	c.2297C>T	c.(2296-2298)TCA>TTA	p.S766L	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.S696L|PDE10A_uc003quo.2_Missense_Mutation_p.S776L	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	766					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GGATGGGGATGAAATCCAGGT	0.502													30	185					0	0	0	0	A	165746557	A	A	165746557	3	1	68	1	0	0	0	0	1	0	0	0	11684	1294	45	2	46	2	PDE10A	6	165746557	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	10615343	165746557	5368510	75	13829											
BRP44L	51660	broad.mit.edu	37	chr6	166796324	166796324	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtcccggaaatccttgcttCggacatagtccgccgctttc	7	11	9	14	4	0	0	0	0	0	0	5	2	3	2	4	2	1	2	4	2	2	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr6:166796324C>T	uc011egn.1	-	1	163	c.41G>A	c.(40-42)CGA>CAA	p.R14Q	BRP44L_uc003qva.2_RNA|BRP44L_uc010kkj.1_Missense_Mutation_p.R14Q	NM_016098	NP_057182	Q9Y5U8	BR44L_HUMAN	brain protein 44-like	14				R -> Q (in Ref. 2; AAD34124).		mitochondrion				central_nervous_system(1)	1		Breast(66;0.000148)|Prostate(117;0.109)|Ovarian(120;0.199)		OV - Ovarian serous cystadenocarcinoma(33;1.8e-19)|BRCA - Breast invasive adenocarcinoma(81;4.68e-06)|GBM - Glioblastoma multiforme(31;0.000122)		ATCCTTGCTTCGGACATAGTC	0.687													3	26					0	0	0	0	T	166796324	T	T	166796324	3	4	68	1	0	0	0	0	1	0	0	0	1524	884	31	1	303	1	BRP44L	6	166796324	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	1049767	166796324	4318743	76	13830											
ZNF12	7559	broad.mit.edu	37	chr7	6732045	6732045	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gttttctcaagcttaatatgGaggagtgatttcccacatcc	10	14	8	9	0	1	1	1	1	1	0	4	3	3	3	2	2	1	2	2	2	3	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr7:6732045G>C	uc003sqt.1	-	5	1082	c.528C>G	c.(526-528)CTC>CTG	p.L176L	ZNF12_uc011jxa.1_Silent_p.L14L|ZNF12_uc003sqs.1_Silent_p.L138L	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	176					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		GCTTAATATGGAGGAGTGATT	0.343													12	90					0	0	0	0	C	6732045	C	C	6732045	2	2	68	1	0	0	0	0	0	0	0	1	17785	1161	41	2		2	ZNF12	7	6732045	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08		6732045	152406618	77	13831											
MACC1	346389	broad.mit.edu	37	chr7	20198241	20198241	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcttttaccttaccttccccGaggagagctattgtgtcccc	6	13	8	14	1	0	1	0	0	0	1	2	3	2	1	6	1	3	2	6	1	3	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr7:20198241G>A	uc003sus.3	-	5	2052	c.1743C>T	c.(1741-1743)CTC>CTT	p.L581L	MACC1_uc010kug.2_Silent_p.L581L	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	581	SH3.				positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TACCTTCCCCGAGGAGAGCTA	0.418													13	301					0	0	0	0	A	20198241	A	A	20198241	2	1	68	1	0	0	0	0	0	0	0	1	9194	1045	37	1		1	MACC1	7	20198241	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	13466196	20198241	138940422	78	13832											
SP4	6671	broad.mit.edu	37	chr7	21550789	21550789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactggactcatctgttacaGaggtgcttggctccccaaga	10	10	10	11	0	2	2	1	0	1	2	3	3	3	3	2	3	3	3	2	3	3	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr7:21550789G>A	uc003sva.2	+	6	2438	c.2257G>A	c.(2257-2259)GAG>AAG	p.E753K	SP4_uc003svb.2_Missense_Mutation_p.E440K	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	753					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						ATCTGTTACAGAGGTGCTTGG	0.448													22	98					0	0	0	0	A	21550789	A	A	21550789	3	1	68	1	0	0	0	0	1	0	0	0	15030	943	33	2	2279	2	SP4	7	21550789	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1352548	21550789	137587874	79	13833											
PPP1R9A	55607	broad.mit.edu	37	chr7	94881081	94881081	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttcttcttaagagagcttGatttcatcaaaagacaggaa	14	14	7	6	0	4	3	2	1	2	2	4	5	4	4	0	1	1	1	0	1	4	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr7:94881081G>C	uc003unp.2	+	10	2620	c.2338G>C	c.(2338-2340)GAT>CAT	p.D780H	PPP1R9A_uc010lfj.2_Missense_Mutation_p.D802H|PPP1R9A_uc011kif.1_Missense_Mutation_p.D780H|PPP1R9A_uc003unq.2_Missense_Mutation_p.D780H|PPP1R9A_uc011kig.1_Missense_Mutation_p.D780H	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	780	Interacts with TGN38 (By similarity).|Potential.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAGAGAGCTTGATTTCATCAA	0.343										HNSCC(28;0.073)			7	58					0	0	0	0	C	94881081	C	C	94881081	3	2	68	1	0	0	0	0	1	0	0	0	12438	1290	45	2	2442	2	PPP1R9A	7	94881081	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	73330292	94881081	64257582	80	13834											
BCAP29	55973	broad.mit.edu	37	chr7	107236385	107236385	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaaaggtgtacttaaaactCaagcagaaaatactaacaag	21	7	6	7	0	1	1	1	0	0	1	1	1	1	1	0	1	5	2	0	1	10	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr7:107236385C>G	uc003vej.2	+	5	757	c.418C>G	c.(418-420)CAA>GAA	p.Q140E	BCAP29_uc011kly.1_Missense_Mutation_p.Q46E|BCAP29_uc011klz.1_Missense_Mutation_p.Q140E|BCAP29_uc011kma.1_Missense_Mutation_p.Q140E	NM_018844	NP_061332	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein BAP29 isoform	140	Cytoplasmic (Potential).				apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				large_intestine(1)|ovary(1)	2						ACTTAAAACTCAAGCAGAAAA	0.299													16	108					0	0	0	0	G	107236385	G	G	107236385	3	3	68	1	0	0	0	0	1	0	0	0	1348	827	29	2	432	2	BCAP29	7	107236385	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	12355304	107236385	51902278	81	13835											
GPR85	54329	broad.mit.edu	37	chr7	112724579	112724579	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaattgcagatctgaggatAtctgaacagcaaagatccaa	17	8	8	8	0	2	4	0	2	2	2	3	5	3	5	1	1	3	2	1	1	5	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr7:112724579A>G	uc010ljv.2	-	2	715	c.198T>C	c.(196-198)GAT>GAC	p.D66D	GPR85_uc003vgp.1_Silent_p.D66D|GPR85_uc003vgq.2_Silent_p.D66D|GPR85_uc010ljw.1_Silent_p.D66D	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	66	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						ATCTGAGGATATCTGAACAGC	0.433													17	126					0	0	0	0	G	112724579	G	G	112724579	2	3	68	1	0	0	0	0	0	0	0	1	6753	446	16	5		5	GPR85	7	112724579	Silent	SNP	A	TCGA-CN-5374-01A-01D-1434-08	5488194	112724579	46414084	82	13836											
ASZ1	136991	broad.mit.edu	37	chr7	117067495	117067495	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgccagccactggcaggcctCgcagcgcgctcgccgccatg	5	4	13	19	6	0	0	0	0	0	0	2	0	0	0	5	2	2	3	5	2	0	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr7:117067495C>T	uc003vjb.2	-	1	83	c.20G>A	c.(19-21)CGA>CAA	p.R7Q	ASZ1_uc011kno.1_Missense_Mutation_p.R7Q|ASZ1_uc011knp.1_5'UTR	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	7					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TGGCAGGCCTCGCAGCGCGCT	0.697											OREG0003439	type=REGULATORY REGION|Gene=ASZ1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	3	10					0	0	0	0	T	117067495	T	T	117067495	3	4	68	1	0	0	0	0	1	0	0	0	1071	884	31	1	1459	1	ASZ1	7	117067495	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	4342916	117067495	42071168	83	13837											
GCC1	79571	broad.mit.edu	37	chr7	127222112	127222112	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggcactggttgggagtcGcattatcacttgtttctcct	5	15	11	10	1	2	0	1	0	1	0	4	1	2	1	1	3	0	5	1	3	1	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr7:127222112G>A	uc003vma.2	-	2	2702	c.2284C>T	c.(2284-2286)CGA>TGA	p.R762*		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	762	Potential.|GRIP.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						GTTGGGAGTCGCATTATCACT	0.517													32	131					0	0	0	0	A	127222112	A	A	127222112	4	1	68	1	0	0	0	0	0	1	0	0	6320	1095	38	1	47	1	GCC1	7	127222112	Nonsense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	10154617	127222112	31916551	84	13838											
CLCN1	1180	broad.mit.edu	37	chr7	143020477	143020477	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtgttctgcggggtatatGaggtaaggttgagacagtga	9	12	16	4	1	1	3	0	3	1	1	1	4	1	3	0	4	1	4	0	4	3	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr7:143020477G>C	uc003wcr.1	+	6	859	c.772G>C	c.(772-774)GAG>CAG	p.E258Q	CLCN1_uc011ktc.1_5'UTR|CLCN1_uc003wcs.1_RNA|CLCN1_uc010lox.1_Intron|CLCN1_uc010loy.1_Intron	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	258					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					CGGGGTATATGAGGTAAGGTT	0.607													5	86					0	0	0	0	C	143020477	C	C	143020477	3	2	68	1	0	0	0	0	1	0	0	0	3477	1291	45	2	794	2	CLCN1	7	143020477	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	15798365	143020477	16118186	85	13839											
GIMAP5	55340	broad.mit.edu	37	chr7	150439815	150439815	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggggctctgtggaggagcaGaggcagcagcaggcagagct	9	5	19	8	0	1	2	0	0	1	2	1	4	1	4	0	6	4	7	0	6	0	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr7:150439815G>C	uc003whr.1	+	3	940	c.588G>C	c.(586-588)CAG>CAC	p.Q196H	GIMAP5_uc010lpu.2_Missense_Mutation_p.Q54H	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	196	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGAGGAGCAGAGGCAGCAGC	0.582													26	66					0	0	0	0	C	150439815	C	C	150439815	3	2	68	1	0	0	0	0	1	0	0	0	6419	933	33	2	594	2	GIMAP5	7	150439815	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	7419338	150439815	8698848	86	13840											
DLGAP2	9228	broad.mit.edu	37	chr8	1497551	1497551	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgacagcacctatcggaCgcccagcgtgctcaaccggc	9	4	11	17	5	1	0	1	0	0	0	2	2	1	1	3	2	5	2	3	2	2	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr8:1497551C>T	uc003wpl.2	+	2	789	c.692C>T	c.(691-693)ACG>ATG	p.T231M	DLGAP2_uc003wpm.2_Missense_Mutation_p.T231M	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	310					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACCTATCGGACGCCCAGCGTG	0.687													13	97					0	0	0	0	T	1497551	T	T	1497551	3	4	68	1	0	0	0	0	1	0	0	0	4582	536	19	1	694	1	DLGAP2	8	1497551	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08		1497551	144866471	87	13841											
RP1L1	94137	broad.mit.edu	37	chr8	10464991	10465038	+	In_Frame_Del	DEL	TGGGCCTCCCCTTCTGCCTCTGGGGCCTCTATACCTTCTGACTCTGGC	-	-																															ctacaccttctaactctggtTgggcctccccttctgcctct																								rs75797924	by1000genomes	TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr8:10464991_10465038delTGGGCCTCCCCTTCTGCCTCTGGGGCCTCTATACCTTCTGACTCTGGC	uc003wtc.2	-	4	6799_6846	c.6570_6617delGCCAGAGTCAGAAGGTATAGAGGCCCCAGAGGCAGAAGGGGAGGCCCA	c.(6568-6618)CAGCCAGAGTCAGAAGGTATAGAGGCCCCAGAGGCAGAAGGGGAGGCCCAA>CAA	p.2190_2206QPESEGIEAPEAEGEAQ>Q		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2190_2206					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TAACTCTGGTTGGGCCTCCCCTTCTGCCTCTGGGGCCTCTATACCTTCTGACTCTGGCTGGGCCTCCC	0.629													---	---	---								-	10465038	-	-	10464991	7	5	68	1	0	1	0	1	0	0	0	0	13598	1812	63	0	589	0	RP1L1	8	10464991	In_Frame_Del	DEL	TGGGCCTCCCCTTCTGCCTCTGGGGCCTCTATACCTTCTGACTCTGGC	TCGA-CN-5374-01A-01D-1434-08	8967440	10464991	135899031	88	13842											
RP1	6101	broad.mit.edu	37	chr8	55541429	55541429	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tttgtccttataattctgtgGaatttcagtgttccaggaaa	10	17	8	6	0	2	0	1	0	1	0	4	2	4	2	2	2	0	1	2	2	4	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr8:55541429G>A	uc003xsd.1	+	4	5135	c.4987G>A	c.(4987-4989)GAA>AAA	p.E1663K	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1663					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TAATTCTGTGGAATTTCAGTG	0.388													74	225					0	0	0	0	A	55541429	A	A	55541429	3	1	68	1	0	0	0	0	1	0	0	0	13597	1175	41	2	4997	2	RP1	8	55541429	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	45076438	55541429	90822593	89	13843											
LRRCC1	85444	broad.mit.edu	37	chr8	86037161	86037161	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaccaaagtcactcagaagAcaacacttaccaggtatgat	17	7	7	10	0	2	4	2	1	0	3	2	4	2	4	2	1	2	1	2	1	5	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr8:86037161A>C	uc003ycw.2	+	8	1413	c.1259A>C	c.(1258-1260)GAC>GCC	p.D420A	LRRCC1_uc010lzz.1_RNA|LRRCC1_uc010maa.1_Missense_Mutation_p.D121A|LRRCC1_uc003ycx.2_Missense_Mutation_p.D327A|LRRCC1_uc003ycy.2_Missense_Mutation_p.D400A	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	420					cell division|mitosis	centriole|nucleus					0						CACTCAGAAGACAACACTTAC	0.299													36	89					0	0	0	0	C	86037161	C	C	86037161	3	2	68	1	0	0	0	0	1	0	0	0	9076	275	10	5	1289	5	LRRCC1	8	86037161	Missense_Mutation	SNP	A	TCGA-CN-5374-01A-01D-1434-08	30495732	86037161	60326861	90	13844											
CSMD3	114788	broad.mit.edu	37	chr8	113323263	113323263	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acccataggaagactttctgCacacagcactgctttttcca	11	11	6	13	0	1	1	0	0	1	1	2	2	2	2	2	1	3	3	2	1	2	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr8:113323263C>A	uc003ynu.2	-	50	7988	c.7829G>T	c.(7828-7830)TGC>TTC	p.C2610F	CSMD3_uc003yns.2_Missense_Mutation_p.C1812F|CSMD3_uc003ynt.2_Missense_Mutation_p.C2570F|CSMD3_uc011lhx.1_Missense_Mutation_p.C2506F|CSMD3_uc003ynw.1_Missense_Mutation_p.C321F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2610	Extracellular (Potential).|Sushi 14.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGACTTTCTGCACACAGCACT	0.463										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	141					5.3912e-06	5.70054e-06	1	0	A	113323263	A	A	113323263	3	1	68	1	0	0	0	0	1	0	0	0	3963	710	25	4	3382	4	CSMD3	8	113323263	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	27286102	113323263	33040759	91	13845											
ENPP2	5168	broad.mit.edu	37	chr8	120602836	120602836	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagttaggtaattactcaaGaactcagttctatcacatgt	13	15	6	7	0	4	1	3	0	1	1	4	1	4	1	0	1	2	3	0	1	7	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr8:120602836G>C	uc003yot.1	-	13	1202	c.1116C>G	c.(1114-1116)TTC>TTG	p.F372L	ENPP2_uc003yor.1_Missense_Mutation_p.F11L|ENPP2_uc003yos.1_Missense_Mutation_p.F424L|ENPP2_uc010mdd.1_Missense_Mutation_p.F372L	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	372					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AATTACTCAAGAACTCAGTTC	0.353													3	86					0	0	0	0	C	120602836	C	C	120602836	3	2	68	1	0	0	0	0	1	0	0	0	5154	933	33	2	1606	2	ENPP2	8	120602836	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	7279573	120602836	25761186	92	13846											
FAM135B	51059	broad.mit.edu	37	chr8	139163666	139163666	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgtccagagtaaaggtctCtgcagaagtcagatgggacc	11	8	13	9	0	2	3	1	0	1	3	4	4	3	4	2	2	1	3	2	2	3	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr8:139163666C>G	uc003yuy.2	-	13	3223	c.3052G>C	c.(3052-3054)GAG>CAG	p.E1018Q	FAM135B_uc003yux.2_Missense_Mutation_p.E919Q|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.E580Q|FAM135B_uc003yvb.2_Missense_Mutation_p.E580Q	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1018										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTAAAGGTCTCTGCAGAAGTC	0.522										HNSCC(54;0.14)			31	51					0	0	0	0	G	139163666	G	G	139163666	3	3	68	1	0	0	0	0	1	0	0	0	5477	922	32	2	1200	2	FAM135B	8	139163666	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	18560830	139163666	7200356	93	13847											
KCNK9	51305	broad.mit.edu	37	chr8	140631107	140631107	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggagaaggcggccgccccGatgcacagcgtccccatgca	8	4	14	15	4	0	1	0	0	0	1	1	3	1	1	5	3	3	2	5	3	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr8:140631107G>A	uc003yvf.1	-	2	583	c.519C>T	c.(517-519)ATC>ATT	p.I173I	KCNK9_uc003yvg.1_Silent_p.I173I|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	173	Helical; (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CGGCCGCCCCGATGCACAGCG	0.562													12	69					0	0	0	0	A	140631107	A	A	140631107	2	1	68	1	0	0	0	0	0	0	0	1	8111	1048	37	1		1	KCNK9	8	140631107	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1467441	140631107	5732915	94	13848											
TYRP1	7306	broad.mit.edu	37	chr9	12704633	12704633	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacccatttgtctccaaatGatcctatttttgtcctcctg	9	16	4	12	0	1	1	0	1	1	0	5	1	4	1	5	0	1	0	5	0	3	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:12704633G>T	uc003zkv.3	+	6	1367	c.1189G>T	c.(1189-1191)GAT>TAT	p.D397Y		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	397	Lumenal, melanosome (Potential).				melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		GTCTCCAAATGATCCTATTTT	0.443									Oculocutaneous_Albinism				24	169					1.42536e-11	1.55823e-11	1	0	T	12704633	T	T	12704633	3	4	68	1	0	0	0	0	1	0	0	0	16884	1290	45	2	1207	2	TYRP1	9	12704633	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08		12704633	128508798	95	13849											
UBQLN1	29979	broad.mit.edu	37	chr9	86324530	86324537	+	5'Flank	DEL	TGTGTGTC	-	-																															tgtgtgtgtgtgtgtgtgtgTgtgtgtctgtctccctgcat																								rs12237346	by1000genomes	TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:86324530_86324537delTGTGTGTC	uc004amv.2	-						UBQLN1_uc004amw.2_5'Flank|uc004amx.2_Intron	NM_013438	NP_038466	Q9UMX0	UBQL1_HUMAN	ubiquilin 1 isoform 1						apoptosis|regulation of protein ubiquitination|response to hypoxia	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm|proteasome complex	kinase binding				0						tgtgtgtgtgtgtgtgtctgtctccctg	0.067													---	---	---								-	86324537	-	-	86324530	6	5	68	0	1	1	0	1	0	0	0	0	16964	1711	59	0		0	UBQLN1	9	86324530	5'Flank	DEL	TGTGTGTC	TCGA-CN-5374-01A-01D-1434-08	73619897	86324530	54888901	96	13850											
IARS	3376	broad.mit.edu	37	chr9	95050073	95050073	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaaaaaacccaacatacCttccactcagcagaatatct	17	8	3	13	0	2	2	1	1	1	1	3	2	3	2	3	0	4	1	3	0	7	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:95050073C>T	uc004art.1	-	4	653	c.396G>A	c.(394-396)AAG>AAA	p.K132K	IARS_uc004ars.1_5'UTR|IARS_uc004aru.3_Silent_p.K132K|IARS_uc010mqr.2_Silent_p.K22K|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	132					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	CCCAACATACCTTCCACTCAG	0.383													31	176					0	0	0	0	T	95050073	T	T	95050073	2	4	68	1	0	0	0	0	0	0	0	1	7512	695	24	4		4	IARS	9	95050073	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	8725543	95050073	46163358	97	13851											
IPPK	64768	broad.mit.edu	37	chr9	95405069	95405069	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggggacagtatttgctgatCtgcttccacttcccagttgc	7	13	10	11	0	1	1	0	1	1	0	3	2	3	2	2	2	3	4	2	2	1	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:95405069C>T	uc004asl.1	-	7	805	c.528G>A	c.(526-528)CAG>CAA	p.Q176Q		NM_022755	NP_073592	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	176					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			ovary(2)	2						ATTTGCTGATCTGCTTCCACT	0.547													8	68					0	0	0	0	T	95405069	T	T	95405069	2	4	68	1	0	0	0	0	0	0	0	1	7840	912	32	2		2	IPPK	9	95405069	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	354996	95405069	45808362	98	13852											
TBC1D2	55357	broad.mit.edu	37	chr9	100971416	100971416	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccgtcaggaagccgtactCatcatacttactgccagcaa	12	8	7	14	2	3	0	3	0	0	0	3	1	3	1	3	1	6	2	3	1	5	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:100971416C>T	uc011lvb.1	-	9	1864	c.1684G>A	c.(1684-1686)GAG>AAG	p.E562K	TBC1D2_uc004ayp.2_Missense_Mutation_p.E102K|TBC1D2_uc004ayq.2_Missense_Mutation_p.E562K|TBC1D2_uc004ayr.2_Missense_Mutation_p.E344K|TBC1D2_uc004ayo.3_Missense_Mutation_p.E562K	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	562						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		AAGCCGTACTCATCATACTTA	0.478													63	342					0	0	0	0	T	100971416	T	T	100971416	3	4	68	1	0	0	0	0	1	0	0	0	15674	835	29	2	1089	2	TBC1D2	9	100971416	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	5566347	100971416	40242015	99	13853											
SVEP1	79987	broad.mit.edu	37	chr9	113220760	113220760	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgaacttgcctgactgctGatttcatgcctctttttaat	9	17	6	9	0	2	3	1	3	1	0	2	3	2	3	2	0	4	1	2	0	3	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:113220760G>A	uc010mtz.2	-	20	3904	c.3567C>T	c.(3565-3567)ATC>ATT	p.I1189I	SVEP1_uc010mua.1_Silent_p.I1189I	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1189					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CCTGACTGCTGATTTCATGCC	0.403													6	43					0	0	0	0	A	113220760	A	A	113220760	2	1	68	1	0	0	0	0	0	0	0	1	15486	1280	45	2		2	SVEP1	9	113220760	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	12249344	113220760	27992671	100	13854											
ZNF483	158399	broad.mit.edu	37	chr9	114304895	114304895	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaattgtggaaaatccttCagtcatagctcatccctttc	11	13	6	11	0	3	0	3	0	0	0	6	1	5	1	2	1	2	2	2	1	4	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:114304895C>T	uc004bff.2	+	6	1904	c.1680C>T	c.(1678-1680)TTC>TTT	p.F560F	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	560	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						GAAAATCCTTCAGTCATAGCT	0.408													16	140					0	0	0	0	T	114304895	T	T	114304895	2	4	68	1	0	0	0	0	0	0	0	1	18003	825	29	2		2	ZNF483	9	114304895	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	1084135	114304895	26908536	101	13855											
ZNF483	158399	broad.mit.edu	37	chr9	114304990	114304990	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaagcctttaggcagaattCatgccttacccggcatcaga	13	9	8	11	1	2	2	2	0	0	2	2	2	2	2	3	2	3	2	3	2	5	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:114304990C>T	uc004bff.2	+	6	1999	c.1775C>T	c.(1774-1776)TCA>TTA	p.S592L	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	592	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						AGGCAGAATTCATGCCTTACC	0.398													13	104					0	0	0	0	T	114304990	T	T	114304990	3	4	68	1	0	0	0	0	1	0	0	0	18003	838	29	2	1793	2	ZNF483	9	114304990	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	95	114304990	26908441	102	13856											
SNX30	401548	broad.mit.edu	37	chr9	115626607	115626607	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgacatggagaggtggcaGaacaacaagaggcaggactt	14	5	15	7	0	0	4	0	1	0	3	0	6	0	5	0	5	2	3	0	5	3	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:115626607G>A	uc004bgj.3	+	8	1330	c.1182G>A	c.(1180-1182)CAG>CAA	p.Q394Q	SNX30_uc004bgi.3_Silent_p.Q76Q	NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	394					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						AGAGGTGGCAGAACAACAAGA	0.512													16	77					0	0	0	0	A	115626607	A	A	115626607	2	1	68	1	0	0	0	0	0	0	0	1	14964	933	33	2		2	SNX30	9	115626607	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1321617	115626607	25586824	103	13857											
RALGPS1	9649	broad.mit.edu	37	chr9	129975312	129975312	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacccagatatcttccagctGaacaaccctgacaaaggtag	14	7	7	13	0	1	3	0	2	1	1	2	3	2	3	3	1	3	2	3	1	5	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:129975312G>A	uc004bqo.1	+	17	1803	c.1536G>A	c.(1534-1536)CTG>CTA	p.L512L	RALGPS1_uc011mac.1_Silent_p.L470L|RALGPS1_uc004bqq.3_Silent_p.L462L	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	512	Required for stimulation of nucleotide exchange by RALA.|PH.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						TCTTCCAGCTGAACAACCCTG	0.542													22	51					0	0	0	0	A	129975312	A	A	129975312	2	1	68	1	0	0	0	0	0	0	0	1	13082	1277	45	2		2	RALGPS1	9	129975312	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	14348705	129975312	11238119	104	13858											
SARDH	1757	broad.mit.edu	37	chr9	136578232	136578232	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccccatcaggggcttgtggtCgggcgtgaaggattctgaaa	8	9	15	9	2	2	2	1	2	1	0	3	3	2	3	2	5	0	1	2	5	2	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:136578232C>G	uc004cep.3	-	9	1299	c.1165G>C	c.(1165-1167)GAC>CAC	p.D389H	SARDH_uc004ceo.2_Missense_Mutation_p.D389H|SARDH_uc011mdn.1_Missense_Mutation_p.D389H|SARDH_uc011mdo.1_Missense_Mutation_p.D221H	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	389					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GGCTTGTGGTCGGGCGTGAAG	0.607													6	23					0	0	0	0	G	136578232	G	G	136578232	3	3	68	1	0	0	0	0	1	0	0	0	13906	884	31	3	1643	3	SARDH	9	136578232	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	6602920	136578232	4635199	105	13859											
BRD3	8019	broad.mit.edu	37	chr9	136906945	136906945	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtccgagctgcctgagtcCgaagagctctcctcactgct	7	9	11	14	2	2	2	1	1	1	1	5	5	4	2	4	0	4	3	4	0	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:136906945C>T	uc004cew.2	-	8	1532	c.1344G>A	c.(1342-1344)TCG>TCA	p.S448S	BRD3_uc004cex.2_Silent_p.S448S	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	448						nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		TGCCTGAGTCCGAAGAGCTCT	0.701			T	NUT|C15orf55	lethal midline carcinoma of young people								11	39					0	0	0	0	T	136906945	T	T	136906945	2	4	68	1	0	0	0	0	0	0	0	1	1508	639	23	1		1	BRD3	9	136906945	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	328713	136906945	4306486	106	13860											
SNAPC4	6621	broad.mit.edu	37	chr9	139273401	139273401	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agaagtgccaggtttggctgCcgcgggggccccaggcccag	6	5	17	13	2	0	1	0	0	0	1	0	1	0	1	5	5	2	2	5	5	1	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr9:139273401C>T	uc004chh.2	-	21	2887	c.2878G>A	c.(2878-2880)GCA>ACA	p.A960T		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	960	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGTTTGGCTGCCGCGGGGGCC	0.657													5	13					0	0	0	0	T	139273401	T	T	139273401	3	4	68	1	0	0	0	0	1	0	0	0	14901	739	26	4	1539	4	SNAPC4	9	139273401	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	2366456	139273401	1940030	107	13861											
GATA3	2625	broad.mit.edu	37	chr10	8115874	8115874	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtcctccctgagccacatctCgcccttcagccactccagcc	6	8	6	21	1	2	1	1	1	1	0	6	1	5	1	7	0	3	0	7	0	0	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr10:8115874C>G	uc001ika.2	+	6	1777	c.1220C>G	c.(1219-1221)TCG>TGG	p.S407W	GATA3_uc001ijz.2_Missense_Mutation_p.S408W	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	407					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						AGCCACATCTCGCCCTTCAGC	0.602			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						3	107					0	0	0	0	G	8115874	G	G	8115874	3	3	68	1	0	0	0	0	1	0	0	0	6290	893	31	3	1241	3	GATA3	10	8115874	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08		8115874	127418873	108	13862											
ARHGAP21	57584	broad.mit.edu	37	chr10	24884722	24884722	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcacattcaaatctcgccaTttctaggtgtacaaaataga	15	12	5	9	1	4	1	2	0	2	1	5	1	4	1	1	1	1	1	1	1	6	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr10:24884722T>C	uc001isb.2	-	19	4123	c.3636A>G	c.(3634-3636)AAA>AAG	p.K1212K	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1211	Rho-GAP.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						AATCTCGCCATTTCTAGGTGT	0.353													17	71					0	0	0	0	C	24884722	C	C	24884722	2	2	68	1	0	0	0	0	0	0	0	1	871	1490	52	5		5	ARHGAP21	10	24884722	Silent	SNP	T	TCGA-CN-5374-01A-01D-1434-08	16768848	24884722	110650025	109	13863											
SLC18A3	6572	broad.mit.edu	37	chr10	50819671	50819671	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctacattgccgtggtggcCggcgcgctcaccacctgtaa	6	8	11	16	4	1	0	1	0	0	0	1	0	1	0	5	3	2	2	5	3	2	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr10:50819671C>T	uc001jhw.2	+	1	1325	c.885C>T	c.(883-885)GCC>GCT	p.A295A	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	295	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						CCGTGGTGGCCGGCGCGCTCA	0.642													17	108					0	0	0	0	T	50819671	T	T	50819671	2	4	68	1	0	0	0	0	0	0	0	1	14492	639	23	1		1	SLC18A3	10	50819671	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	25934949	50819671	84715076	110	13864											
SGMS1	259230	broad.mit.edu	37	chr10	52071137	52071137	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacctccagcaatgagcttCattattcttcgcagttgggc	8	12	8	13	1	2	1	1	1	1	0	4	1	3	1	3	1	2	4	3	1	2	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr10:52071137C>T	uc001jje.2	-	9	1734	c.780G>A	c.(778-780)ATG>ATA	p.M260I	SGMS1_uc010qhk.1_Missense_Mutation_p.M91I|SGMS1_uc009xot.1_RNA	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	266					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						CAATGAGCTTCATTATTCTTC	0.463													10	73					0	0	0	0	T	52071137	T	T	52071137	3	4	68	1	0	0	0	0	1	0	0	0	14279	826	29	2	473	2	SGMS1	10	52071137	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	1251466	52071137	83463610	111	13865											
VCL	7414	broad.mit.edu	37	chr10	75874638	75874638	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgggccggaccaacatcaGtgatgaggagtctgagcagg	10	6	16	9	1	2	3	1	3	1	0	2	5	2	5	2	4	2	2	2	4	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr10:75874638G>C	uc001jwd.2	+	21	3333	c.3239G>C	c.(3238-3240)AGT>ACT	p.S1080T	VCL_uc009xrr.2_Missense_Mutation_p.S761T|VCL_uc001jwe.2_Missense_Mutation_p.S1012T|VCL_uc010qkz.1_Missense_Mutation_p.S273T	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	1080	C-terminal tail.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					ACCAACATCAGTGATGAGGAG	0.483													2	7					0	0	0	0	C	75874638	C	C	75874638	3	2	68	1	0	0	0	0	1	0	0	0	17207	1029	36	4	3321	4	VCL	10	75874638	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	23803501	75874638	59660109	112	13866											
KIF11	3832	broad.mit.edu	37	chr10	94376578	94376578	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcagaaactcaccaaaaaaGctcttattaaggtaactgtg	17	10	6	8	0	3	1	2	0	1	1	3	1	3	1	1	1	3	2	1	1	7	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr10:94376578G>A	uc001kic.2	+	9	1425	c.1117G>A	c.(1117-1119)GCT>ACT	p.A373T	KIF11_uc010qnq.1_Intron	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	373	Potential.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1						CACCAAAAAAGCTCTTATTAA	0.323													16	89					0	0	0	0	A	94376578	A	A	94376578	3	1	68	1	0	0	0	0	1	0	0	0	8311	971	34	4	1151	4	KIF11	10	94376578	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	18501940	94376578	41158169	113	13867											
PYROXD2	84795	broad.mit.edu	37	chr10	100167372	100167372	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagtgtaaatctgcggcctCagcaggctgagcaggtagga	10	8	14	9	1	3	1	2	1	1	0	3	2	3	2	1	4	3	5	1	4	3	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr10:100167372C>T	uc001kpc.2	-	4	368	c.282G>A	c.(280-282)CTG>CTA	p.L94L	PYROXD2_uc001kpb.2_RNA|PYROXD2_uc001kpd.2_RNA|PYROXD2_uc010qpe.1_Silent_p.L94L	NM_032709	NP_116098	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase	94							oxidoreductase activity			central_nervous_system(1)	1						TCTGCGGCCTCAGCAGGCTGA	0.607													6	45					0	0	0	0	T	100167372	T	T	100167372	2	4	68	1	0	0	0	0	0	0	0	1	12932	813	29	2		2	PYROXD2	10	100167372	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	5790794	100167372	35367375	114	13868											
ATRNL1	26033	broad.mit.edu	37	chr10	116889158	116889158	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtgtctctgttccaagtcaAgtatattgtgaatgtgataa	12	15	9	5	0	2	2	1	2	1	0	4	2	3	2	1	0	0	2	1	0	6	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr10:116889158A>G	uc001lcg.2	+	5	1076	c.690A>G	c.(688-690)CAA>CAG	p.Q230Q	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Silent_p.Q230Q|ATRNL1_uc009xyq.2_Silent_p.Q230Q	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	230	EGF-like 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TTCCAAGTCAAGTATATTGTG	0.373													6	115					0	0	0	0	G	116889158	G	G	116889158	2	3	68	1	0	0	0	0	0	0	0	1	1209	69	3	5		5	ATRNL1	10	116889158	Silent	SNP	A	TCGA-CN-5374-01A-01D-1434-08	16721786	116889158	18645589	115	13869											
C10orf82	143379	broad.mit.edu	37	chr10	118425270	118425270	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgctgtgttttctcctggaaGgttttcacacagtggttcat	6	16	10	9	1	3	0	2	0	1	0	4	1	3	1	1	3	0	4	1	3	1	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr10:118425270G>T	uc001lcr.2	-	3	178	c.123C>A	c.(121-123)ACC>ACA	p.T41T	C10orf82_uc001lcs.1_Silent_p.T41T	NM_144661	NP_653262	Q8WW14	CJ082_HUMAN	hypothetical protein LOC143379	41											0				all cancers(201;0.0143)		TCTCCTGGAAGGTTTTCACAC	0.532													11	103					0.00136819	0.00140077	1	0	T	118425270	T	T	118425270	2	4	68	1	0	0	0	0	0	0	0	1	1626	987	35	4		4	C10orf82	10	118425270	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1536112	118425270	17109477	116	13870											
IKZF5	64376	broad.mit.edu	37	chr10	124753991	124753991	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctcttctgctatagcccaGattgcttgttttcttctgta	5	19	7	10	0	4	1	0	0	4	1	4	1	4	1	1	0	4	5	1	0	3	9			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr10:124753991G>A	uc001lha.2	-	5	864	c.565C>T	c.(565-567)CTG>TTG	p.L189L	IKZF5_uc001lgz.2_Silent_p.L27L	NM_022466	NP_071911	Q9H5V7	IKZF5_HUMAN	zinc finger protein, subfamily 1A, 5	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		CTATAGCCCAGATTGCTTGTT	0.413													43	279					0	0	0	0	A	124753991	A	A	124753991	2	1	68	1	0	0	0	0	0	0	0	1	7657	933	33	2		2	IKZF5	10	124753991	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	6328721	124753991	10780756	117	13871											
DCHS1	8642	broad.mit.edu	37	chr11	6643167	6643167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgggggacatggcagctGaggacagggagccttcatgg	9	6	18	8	0	1	1	1	1	0	0	1	4	1	4	1	6	3	3	1	6	0	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:6643167G>A	uc001mem.1	-	21	10150	c.9740C>T	c.(9739-9741)TCA>TTA	p.S3247L	TPP1_uc001mek.1_5'Flank|TPP1_uc001mel.1_5'Flank|TPP1_uc010rar.1_5'Flank	NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	3247	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATGGCAGCTGAGGACAGGGA	0.632													8	20					0	0	0	0	A	6643167	A	A	6643167	3	1	68	1	0	0	0	0	1	0	0	0	4304	1294	45	2	160	2	DCHS1	11	6643167	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08		6643167	128363349	118	13872											
NAV2	89797	broad.mit.edu	37	chr11	20067214	20067214	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcctctcccacactccgCaggtaagtgagtacataaat	11	9	9	12	1	1	1	0	1	1	0	3	1	2	1	3	2	1	3	3	2	4	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:20067214C>A	uc010rdm.1	+	15	4330	c.3969C>A	c.(3967-3969)CGC>CGA	p.R1323R	NAV2_uc001mpp.2_Silent_p.R1236R|NAV2_uc001mpr.3_Silent_p.R1300R|NAV2_uc001mpt.2_Silent_p.R386R|NAV2_uc009yhx.2_Silent_p.R386R|NAV2_uc009yhy.1_Silent_p.R299R	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1323						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						CCACACTCCGCAGGTAAGTGA	0.517													16	39					5.01169e-05	5.23489e-05	1	0	A	20067214	A	A	20067214	2	1	68	1	0	0	0	0	0	0	0	1	10237	697	25	4		4	NAV2	11	20067214	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	13424047	20067214	114939302	119	13873											
ANO3	63982	broad.mit.edu	37	chr11	26552873	26552873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggccccttcagccgtgcaCggattcaccagtgagttccc	6	9	10	16	2	2	1	2	1	0	0	3	2	3	2	5	2	2	2	5	2	0	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:26552873C>T	uc001mqt.3	+	8	1004	c.859C>T	c.(859-861)CGG>TGG	p.R287W	ANO3_uc010rdr.1_Missense_Mutation_p.R271W|ANO3_uc010rds.1_Missense_Mutation_p.R126W|ANO3_uc010rdt.1_Missense_Mutation_p.R141W	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	287	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAGCCGTGCACGGATTCACCA	0.453													4	180					0	0	0	0	T	26552873	T	T	26552873	3	4	68	1	0	0	0	0	1	0	0	0	698	527	19	1	889	1	ANO3	11	26552873	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	6485659	26552873	108453643	120	13874											
TNKS1BP1	85456	broad.mit.edu	37	chr11	57080450	57080450	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgccctcagttgtaggcaggGgctcaaggggaacagctggg	8	7	17	9	0	2	0	2	0	0	0	2	1	2	1	1	6	3	5	1	6	3	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:57080450G>A	uc001njr.2	-	4	2024	c.1712C>T	c.(1711-1713)CCC>CTC	p.P571L	TNKS1BP1_uc001njs.2_Missense_Mutation_p.P571L|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.P22L	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	571	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				TGTAGGCAGGGGCTCAAGGGG	0.597													21	74					0	0	0	0	A	57080450	A	A	57080450	3	1	68	1	0	0	0	0	1	0	0	0	16386	1232	43	4	3505	4	TNKS1BP1	11	57080450	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	30527577	57080450	77926066	121	13875											
CCDC87	55231	broad.mit.edu	37	chr11	66358149	66358149	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagggaaaccaaagaagactCcattaagttgagcttcctgt	14	9	10	8	0	0	3	0	1	0	2	2	5	2	4	3	1	2	2	3	1	4	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:66358149C>G	uc001oiq.3	-	1	2406	c.2338G>C	c.(2338-2340)GAG>CAG	p.E780Q	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	780										ovary(1)|skin(1)	2						AAAGAAGACTCCATTAAGTTG	0.498													43	237					0	0	0	0	G	66358149	G	G	66358149	3	3	68	1	0	0	0	0	1	0	0	0	2875	864	30	2	215	2	CCDC87	11	66358149	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	9277699	66358149	68648367	122	13876											
CCDC87	55231	broad.mit.edu	37	chr11	66358638	66358638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccacaggaacctcttcttCatgcatttgaaagatgacat	12	12	6	11	0	3	3	1	2	2	1	4	4	4	4	2	1	2	1	2	1	2	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:66358638C>T	uc001oiq.3	-	1	1917	c.1849G>A	c.(1849-1851)GAA>AAA	p.E617K	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	617										ovary(1)|skin(1)	2						ACCTCTTCTTCATGCATTTGA	0.468													44	144					0	0	0	0	T	66358638	T	T	66358638	3	4	68	1	0	0	0	0	1	0	0	0	2875	835	29	2	704	2	CCDC87	11	66358638	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	489	66358638	68647878	123	13877											
PC	5091	broad.mit.edu	37	chr11	66619400	66619400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatacaggaagcgcatggCgacgtcaaacgtggctcctg	10	7	12	12	4	2	0	2	0	0	0	3	2	3	1	1	3	3	2	1	3	3	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:66619400C>T	uc001ojn.1	-	14	1892	c.1843G>A	c.(1843-1845)GCC>ACC	p.A615T	PC_uc001ojo.1_Missense_Mutation_p.A615T|PC_uc001ojp.1_Missense_Mutation_p.A615T|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	615	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	AAGCGCATGGCGACGTCAAAC	0.637													7	37					0	0	0	0	T	66619400	T	T	66619400	3	4	68	1	0	0	0	0	1	0	0	0	11551	768	27	1	1725	1	PC	11	66619400	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	260762	66619400	68387116	124	13878											
SUV420H1	51111	broad.mit.edu	37	chr11	67925239	67925239	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttttccaactattaacctCaagcgcttagctggaggaag	11	12	8	10	1	2	0	1	0	1	0	3	2	3	2	2	2	4	2	2	2	6	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:67925239C>G	uc001onm.1	-	11	2830	c.2574G>C	c.(2572-2574)TTG>TTC	p.L858F	SUV420H1_uc009yse.1_Missense_Mutation_p.L444F|SUV420H1_uc001onn.1_Missense_Mutation_p.L686F|SUV420H1_uc009ysf.2_Missense_Mutation_p.L618F	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	858					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CTATTAACCTCAAGCGCTTAG	0.403													17	73					0	0	0	0	G	67925239	G	G	67925239	3	3	68	1	0	0	0	0	1	0	0	0	15480	825	29	2	87	2	SUV420H1	11	67925239	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	1305839	67925239	67081277	125	13879											
FUT4	2526	broad.mit.edu	37	chr11	94278550	94278550	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggctttcgagaactcgcaGcacctggattatatcaccga	10	10	9	12	3	1	1	1	0	0	1	3	4	1	2	2	2	2	3	2	2	3	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:94278550G>A	uc001pez.2	+	1	1534	c.1251G>A	c.(1249-1251)CAG>CAA	p.Q417Q	PIWIL4_uc010rue.1_Intron|PIWIL4_uc009ywk.1_5'Flank	NM_002033	NP_002024	P22083	FUT4_HUMAN	fucosyltransferase 4	417	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			skin(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGAACTCGCAGCACCTGGATT	0.652													3	39					0	0	0	0	A	94278550	A	A	94278550	2	1	68	1	0	0	0	0	0	0	0	1	6140	962	34	4		4	FUT4	11	94278550	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	26353311	94278550	40727966	126	13880											
ZBTB16	7704	broad.mit.edu	37	chr11	114027138	114027138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atagtttgcggctgagaatgCacttactggctcattcaggt	9	13	11	8	1	2	1	2	1	0	1	2	2	2	1	0	3	3	4	0	3	3	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:114027138C>T	uc001pop.2	+	3	1612	c.1348C>T	c.(1348-1350)CAC>TAC	p.H450Y	ZBTB16_uc001poo.1_Missense_Mutation_p.H450Y|ZBTB16_uc001poq.2_Missense_Mutation_p.H450Y	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	450	C2H2-type 2.				apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		GCTGAGAATGCACTTACTGGC	0.547													8	51					0	0	0	0	T	114027138	T	T	114027138	3	4	68	1	0	0	0	0	1	0	0	0	17593	710	25	4	1354	4	ZBTB16	11	114027138	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	19748588	114027138	20979378	127	13881											
TECTA	7007	broad.mit.edu	37	chr11	120996298	120996298	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgtgtgtaccacgcagactgGaagtgcgactccggctgcgt	7	8	14	12	5	0	1	0	0	0	1	1	3	1	2	2	2	3	3	2	2	2	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr11:120996298G>C	uc010rzo.1	+	7	1491	c.1491G>C	c.(1489-1491)TGG>TGC	p.W497C		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	497	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ACGCAGACTGGAAGTGCGACT	0.587													30	96					0	0	0	0	C	120996298	C	C	120996298	3	2	68	1	0	0	0	0	1	0	0	0	15813	1183	41	2	1517	2	TECTA	11	120996298	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	6969160	120996298	14010218	128	13882											
NRIP2	83714	broad.mit.edu	37	chr12	2939891	2939891	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccttgcagttgaccagaaGagctggaatctctgtcctgc	9	10	10	12	0	1	3	0	1	1	2	3	4	2	4	3	1	3	3	3	1	2	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr12:2939891G>A	uc001qlc.2	-	2	550	c.478C>T	c.(478-480)CTT>TTT	p.L160F	NRIP2_uc010sed.1_Missense_Mutation_p.L160F	NM_031474	NP_113662	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	160					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			TTGACCAGAAGAGCTGGAATC	0.572													32	62					0	0	0	0	A	2939891	A	A	2939891	3	1	68	1	0	0	0	0	1	0	0	0	10707	942	33	2	387	2	NRIP2	12	2939891	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08		2939891	130912004	129	13883											
CLEC4C	170482	broad.mit.edu	37	chr12	7883477	7883477	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagccccagaaaataagaaGaatttcttttcagattctga	16	11	6	8	0	3	5	1	1	2	4	3	5	3	5	2	0	1	0	2	0	5	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr12:7883477G>T	uc001qtg.1	-	5	587	c.413C>A	c.(412-414)TCT>TAT	p.S138Y	CLEC4C_uc001qth.1_Missense_Mutation_p.S138Y|CLEC4C_uc001qti.1_Missense_Mutation_p.S107Y	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	138	Extracellular (Potential).|C-type lectin.				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		AAAATAAGAAGAATTTCTTTT	0.343													52	106					2.17126e-26	2.44622e-26	1	0	T	7883477	T	T	7883477	3	4	68	1	0	0	0	0	1	0	0	0	3528	942	33	2	236	2	CLEC4C	12	7883477	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	4943586	7883477	125968418	130	13884											
TMEM106C	79022	broad.mit.edu	37	chr12	48359698	48359698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcttcctgtttccgcattCagtccttgtggatgatgacg	5	17	9	10	2	2	2	1	2	1	0	5	3	5	3	3	1	0	2	3	1	0	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr12:48359698C>T	uc001rqp.2	+	4	444	c.329C>T	c.(328-330)TCA>TTA	p.S110L	TMEM106C_uc001rqo.2_Missense_Mutation_p.S110L|TMEM106C_uc001rqr.2_Missense_Mutation_p.S110L|TMEM106C_uc001rqq.2_Missense_Mutation_p.S110L	NM_024056	NP_076961	Q9BVX2	T106C_HUMAN	transmembrane protein 106C isoform a	110						endoplasmic reticulum membrane|integral to membrane					0		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		TTTCCGCATTCAGTCCTTGTG	0.448													200	368					0	0	0	0	T	48359698	T	T	48359698	3	4	68	1	0	0	0	0	1	0	0	0	16088	838	29	2	339	2	TMEM106C	12	48359698	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	40476221	48359698	85492197	131	13885											
COL2A1	1280	broad.mit.edu	37	chr12	48388219	48388219	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtttacctgaggaccaggCggacccctttcaccagcttt	7	10	10	14	2	1	1	1	1	0	0	1	3	1	3	5	3	2	2	5	3	1	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr12:48388219C>T	uc001rqu.2	-	12	985	c.804G>A	c.(802-804)CCG>CCA	p.P268P	COL2A1_uc001rqv.2_Silent_p.P199P	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	268	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GAGGACCAGGCGGACCCCTTT	0.557													16	53					0	0	0	0	T	48388219	T	T	48388219	2	4	68	1	0	0	0	0	0	0	0	1	3702	755	27	1		1	COL2A1	12	48388219	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	28521	48388219	85463676	132	13886											
ANO4	121601	broad.mit.edu	37	chr12	101493406	101493406	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtacgacaagaacatggacCtgaaaggaaaataagtttcc	18	7	9	7	1	0	2	0	1	0	1	1	5	1	4	2	2	2	2	2	2	7	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr12:101493406C>A	uc010svm.1	+	22	2629	c.2057C>A	c.(2056-2058)CCT>CAT	p.P686H	ANO4_uc001thw.2_Missense_Mutation_p.P651H|ANO4_uc001thx.2_Missense_Mutation_p.P686H|ANO4_uc001thy.2_Missense_Mutation_p.P206H	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	686	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GAACATGGACCTGAAAGGAAA	0.363										HNSCC(74;0.22)			48	84					2.13384e-23	2.39361e-23	1	0	A	101493406	A	A	101493406	3	1	68	1	0	0	0	0	1	0	0	0	699	681	24	4	2030	4	ANO4	12	101493406	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	53105187	101493406	32358489	133	13887											
NAA25	80018	broad.mit.edu	37	chr12	112492280	112492280	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acccagcatacagtagattcGaacaagcagcaatttgaact	16	8	7	10	1	0	2	0	1	0	1	1	3	0	2	1	0	6	4	1	0	6	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr12:112492280G>A	uc001ttm.2	-	14	1560	c.1540C>T	c.(1540-1542)CGA>TGA	p.R514*	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Nonsense_Mutation_p.R486*|NAA25_uc009zwa.1_Nonsense_Mutation_p.R514*	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	514						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						CAGTAGATTCGAACAAGCAGC	0.478													21	86					0	0	0	0	A	112492280	A	A	112492280	4	1	68	1	0	0	0	0	0	1	0	0	10174	1066	37	1	1422	1	NAA25	12	112492280	Nonsense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	10998874	112492280	21359615	134	13888											
OAS2	4939	broad.mit.edu	37	chr12	113445710	113445710	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaactttgaagatgagacCgtgaggaagtttctactgag	13	11	11	6	1	1	5	0	4	1	2	1	7	1	6	1	1	3	1	1	1	5	4	rs45514594	byFrequency	TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr12:113445710C>T	uc001tuj.2	+	9	1997	c.1857C>T	c.(1855-1857)ACC>ACT	p.T619T	OAS2_uc001tui.1_Silent_p.T619T	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	619	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						AAGATGAGACCGTGAGGAAGT	0.483													5	322					0	0	0	0	T	113445710	T	T	113445710	2	4	68	1	0	0	0	0	0	0	0	1	10854	639	23	1		1	OAS2	12	113445710	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	953430	113445710	20406185	135	13889											
GATC	283459	broad.mit.edu	37	chr12	120884532	120884532	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgtggacttcggcagccgcGaggcagtggcgcgactggag	6	7	18	10	5	0	0	0	0	0	0	1	4	0	2	1	5	1	2	1	5	0	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr12:120884532G>A	uc010szi.1	+	2	154	c.154G>A	c.(154-156)GAG>AAG	p.E52K	TRIAP1_uc001tyg.2_5'Flank	NM_176818	NP_789788	O43716	GATCL_HUMAN	glutamyl-tRNA(Gln) amidotransferase, subunit C	52					regulation of translational fidelity						0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGGCAGCCGCGAGGCAGTGGC	0.672													16	38					0	0	0	0	A	120884532	A	A	120884532	3	1	68	1	0	0	0	0	1	0	0	0	6297	1059	37	1	160	1	GATC	12	120884532	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	7438822	120884532	12967363	136	13890											
GPR133	283383	broad.mit.edu	37	chr12	131593382	131593382	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgatcaaggtctttgggtcGgaggacagcaagcaccgtta	10	9	14	8	2	2	1	1	1	1	0	3	3	2	3	1	4	2	3	1	4	3	2	rs60880996	byFrequency	TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr12:131593382G>A	uc001uit.3	+	18	2560	c.2001G>A	c.(1999-2001)TCG>TCA	p.S667S	GPR133_uc010tbm.1_Silent_p.S699S|GPR133_uc009zyo.2_Intron|GPR133_uc001uiv.1_Silent_p.S186S|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	667	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TCTTTGGGTCGGAGGACAGCA	0.348													73	141					0	0	0	0	A	131593382	A	A	131593382	2	1	68	1	0	0	0	0	0	0	0	1	6681	1103	39	1		1	GPR133	12	131593382	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	10708850	131593382	2258513	137	13891											
CARS2	79587	broad.mit.edu	37	chr13	111340150	111340150	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaatattttcggttaccctCaggtacaccgtgggtgggag	8	11	14	8	2	1	0	1	0	0	0	2	2	1	2	2	5	2	2	2	5	4	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr13:111340150C>T	uc001vrd.2	-	5	529	c.489G>A	c.(487-489)CTG>CTA	p.L163L	CARS2_uc010tjm.1_RNA	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	163					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	CGGTTACCCTCAGGTACACCG	0.478													42	176					0	0	0	0	T	111340150	T	T	111340150	2	4	68	1	0	0	0	0	0	0	0	1	2670	813	29	2		2	CARS2	13	111340150	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08		111340150	3829728	138	13892											
OR4E2	26686	broad.mit.edu	37	chr14	22133750	22133750	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctttgctctctggttggggGgtactgttcactcactaggg	4	15	13	9	0	4	0	2	0	2	0	5	0	4	0	0	5	2	4	0	5	2	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr14:22133750G>A	uc010tmd.1	+	1	454	c.454G>A	c.(454-456)GGT>AGT	p.G152S		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CTGGTTGGGGGGTACTGTTCA	0.478													35	219					0	0	0	0	A	22133750	A	A	22133750	3	1	68	1	0	0	0	0	1	0	0	0	11114	1232	43	4	456	4	OR4E2	14	22133750	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08		22133750	85215790	139	13893											
PRMT5	10419	broad.mit.edu	37	chr14	23395383	23395383	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctctggtgcatcttagaaaGaacaggaaatcccttcttat	12	12	7	10	0	3	2	0	0	3	2	4	3	4	3	2	2	2	1	2	2	5	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr14:23395383G>A	uc001whm.1	-	7	827	c.736C>T	c.(736-738)CTT>TTT	p.L246F	PRMT5_uc001whl.1_Missense_Mutation_p.L229F|PRMT5_uc010akd.1_RNA|PRMT5_uc010tnf.1_Missense_Mutation_p.L140F|PRMT5_uc010tng.1_Missense_Mutation_p.L185F|PRMT5_uc010tnh.1_Missense_Mutation_p.L202F|PRMT5_uc001whn.1_Intron	NM_006109	NP_006100	O14744	ANM5_HUMAN	protein arginine methyltransferase 5 isoform a	246					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			ovary(1)	1	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		ATCTTAGAAAGAACAGGAAAT	0.478													49	133					0	0	0	0	A	23395383	A	A	23395383	3	1	68	1	0	0	0	0	1	0	0	0	12601	942	33	2	1221	2	PRMT5	14	23395383	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1261633	23395383	83954157	140	13894											
MYH6	4624	broad.mit.edu	37	chr14	23858700	23858700	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattagcgcctccttttcctCtagctgccgggccaactctc	5	12	8	16	2	2	0	0	0	2	0	5	1	4	0	5	1	4	1	5	1	3	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr14:23858700C>T	uc001wjv.2	-	28	3947	c.3880G>A	c.(3880-3882)GAG>AAG	p.E1294K	uc010tnn.1_5'Flank|MIR208A_hsa-mir-208a|MI0000251_5'Flank	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1294	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCCTTTTCCTCTAGCTGCCGG	0.587													9	159					0	0	0	0	T	23858700	T	T	23858700	3	4	68	1	0	0	0	0	1	0	0	0	10091	922	32	2	1987	2	MYH6	14	23858700	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	463317	23858700	83490840	141	13895											
CMA1	1215	broad.mit.edu	37	chr14	24976609	24976609	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acaaagttccgtcttataagGaaaccaccacaaaattttga	17	10	5	9	1	1	1	0	1	1	0	2	2	2	2	3	1	1	1	3	1	6	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr14:24976609G>C	uc001wpp.1	-	2	192	c.162C>G	c.(160-162)TTC>TTG	p.F54L	CMA1_uc010alx.1_Intron	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	54	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		GTCTTATAAGGAAACCACCAC	0.483													58	273					0	0	0	0	C	24976609	C	C	24976609	3	2	68	1	0	0	0	0	1	0	0	0	3589	1165	41	2	597	2	CMA1	14	24976609	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1117909	24976609	82372931	142	13896											
DAAM1	23002	broad.mit.edu	37	chr14	59819342	59819342	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgataggttcctttttgaGatgagccggtgagtttgaaa	9	14	13	5	1	0	5	0	5	0	1	1	6	1	5	2	2	1	3	2	2	2	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr14:59819342G>C	uc001xdz.1	+	19	2414	c.2289G>C	c.(2287-2289)GAG>GAC	p.E763D	DAAM1_uc001xea.1_Missense_Mutation_p.E753D|DAAM1_uc001xec.1_5'Flank	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	763	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		TCCTTTTTGAGATGAGCCGGT	0.398													15	46					0	0	0	0	C	59819342	C	C	59819342	3	2	68	1	0	0	0	0	1	0	0	0	4232	933	33	2	2359	2	DAAM1	14	59819342	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	34842733	59819342	47530198	143	13897											
ACTC1	70	broad.mit.edu	37	chr15	35086908	35086908	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgggcggcccacgatggaCgggaagacagcgcggggcgc	7	1	20	13	8	0	1	0	0	0	1	0	4	0	3	1	6	1	0	1	6	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr15:35086908C>A	uc001ziu.1	-	2	345	c.102G>T	c.(100-102)CCG>CCT	p.P34P	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	34					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		CCACGATGGACGGGAAGACAG	0.682													20	82					3.51602e-12	3.86014e-12	1	0	A	35086908	A	A	35086908	2	1	68	1	0	0	0	0	0	0	0	1	195	523	19	3		3	ACTC1	15	35086908	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08		35086908	67444484	144	13898											
DUOX1	53905	broad.mit.edu	37	chr15	45426426	45426426	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccccacctgcccaaccccCgagaccttagcaacaccatc	12	4	4	21	1	0	1	0	0	0	1	1	2	0	1	8	0	5	1	8	0	4	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr15:45426426C>T	uc001zus.1	+	5	572	c.226C>T	c.(226-228)CGA>TGA	p.R76*	DUOX1_uc001zut.1_Nonsense_Mutation_p.R76*|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	76	Peroxidase-like; mediates peroxidase activity.|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		GCCCAACCCCCGAGACCTTAG	0.627													18	144					0	0	0	0	T	45426426	T	T	45426426	4	4	68	1	0	0	0	0	0	1	0	0	4822	644	23	1	236	1	DUOX1	15	45426426	Nonsense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	10339518	45426426	57104966	145	13899											
UNC13C	440279	broad.mit.edu	37	chr15	54306794	54306794	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcttactcagaagatttttCagaaaatcagtttttcacta	13	16	5	7	0	5	3	4	0	1	3	5	3	5	3	0	0	1	1	0	0	5	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr15:54306794C>T	uc002ack.2	+	1	1694	c.1694C>T	c.(1693-1695)TCA>TTA	p.S565L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	565					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GAAGATTTTTCAGAAAATCAG	0.423													9	74					0	0	0	0	T	54306794	T	T	54306794	3	4	68	1	0	0	0	0	1	0	0	0	17054	838	29	2	1696	2	UNC13C	15	54306794	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	8880368	54306794	48224598	146	13900											
AAGAB	79719	broad.mit.edu	37	chr15	67528335	67528335	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	accatcctcctcaggcaactCctctggactaagttctacca	10	10	5	16	0	3	0	1	0	2	0	6	1	6	1	5	2	2	2	5	2	3	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr15:67528335C>T	uc002aqk.3	-	4	538	c.433G>A	c.(433-435)GAG>AAG	p.E145K	AAGAB_uc002aql.2_Missense_Mutation_p.E36K|AAGAB_uc010uju.1_Missense_Mutation_p.E36K	NM_024666	NP_078942	Q6PD74	AAGAB_HUMAN	alpha- and gamma-adaptin-binding protein p34	145					protein transport	cytoplasm					0						TCAGGCAACTCCTCTGGACTA	0.353													40	236					0	0	0	0	T	67528335	T	T	67528335	3	4	68	1	0	0	0	0	1	0	0	0	15	864	30	2	542	2	AAGAB	15	67528335	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	13221541	67528335	35003057	147	13901											
MEX3B	84206	broad.mit.edu	37	chr15	82336383	82336383	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctagagaaaggcttgcggccGggggtgggcgtgatgctggg	6	7	21	7	3	0	2	0	1	0	1	0	3	0	2	1	6	2	2	1	6	2	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr15:82336383G>A	uc002bgq.1	-	2	1143	c.828C>T	c.(826-828)CCC>CCT	p.P276P		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	276					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						GCTTGCGGCCGGGGGTGGGCG	0.662													10	46					0	0	0	0	A	82336383	A	A	82336383	2	1	68	1	0	0	0	0	0	0	0	1	9563	1103	39	1		1	MEX3B	15	82336383	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	14808048	82336383	20195009	148	13902											
ALPK3	57538	broad.mit.edu	37	chr15	85400161	85400161	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcaagaggtggcaaccaGcctcggcccaccatccagaa	12	4	11	14	1	0	3	0	1	0	2	2	3	1	3	5	3	3	2	5	3	3	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr15:85400161G>A	uc002ble.2	+	6	2965	c.2798G>A	c.(2797-2799)AGC>AAC	p.S933N		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	933					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GTGGCAACCAGCCTCGGCCCA	0.582													27	158					0	0	0	0	A	85400161	A	A	85400161	3	1	68	1	0	0	0	0	1	0	0	0	546	971	34	4	2820	4	ALPK3	15	85400161	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	3063778	85400161	17131231	149	13903											
HAGH	3029	broad.mit.edu	37	chr16	1859322	1859322	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaactggtccttctccctgcGcacggcccgcatggtggtca	5	9	12	15	3	2	0	1	0	1	0	4	1	3	0	3	4	2	2	3	4	1	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr16:1859322G>A	uc002cna.2	-	9	1296	c.889C>T	c.(889-891)CGC>TGC	p.R297C	HAGH_uc002cmz.2_Missense_Mutation_p.R249C|HAGH_uc010uvp.1_3'UTR|HAGH_uc002cnb.1_3'UTR	NM_005326	NP_005317	Q16775	GLO2_HUMAN	hydroxyacylglutathione hydrolase isoform 1	297	Substrate.				glutathione biosynthetic process	cytoplasm|mitochondrial matrix|mitochondrial matrix	hydroxyacylglutathione hydrolase activity|zinc ion binding			ovary(1)	1		Hepatocellular(780;0.00335)			Glutathione(DB00143)	TTCTCCCTGCGCACGGCCCGC	0.652													7	269					0	0	0	0	A	1859322	A	A	1859322	3	1	68	1	0	0	0	0	1	0	0	0	6984	1087	38	1	41	1	HAGH	16	1859322	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08		1859322	88495431	150	13904											
PKMYT1	9088	broad.mit.edu	37	chr16	3024073	3024073	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcagggtggtgagccaggcGgggtggctggcgggcccagg	4	5	23	9	2	0	1	0	1	0	0	0	1	0	1	2	9	2	2	2	9	0	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr16:3024073G>T	uc002csn.2	-	7	1681	c.1238C>A	c.(1237-1239)CCG>CAG	p.P413Q	PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_Missense_Mutation_p.P413Q|PKMYT1_uc002cso.2_Missense_Mutation_p.P344Q|PKMYT1_uc002csp.2_Missense_Mutation_p.P404Q|PKMYT1_uc002csq.2_Missense_Mutation_p.P404Q|PKMYT1_uc010bsy.1_Missense_Mutation_p.P404Q	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	413	Interaction with PIN1.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1						TGAGCCAGGCGGGGTGGCTGG	0.677													5	28					1.23904e-05	1.29948e-05	1	0	T	3024073	T	T	3024073	3	4	68	1	0	0	0	0	1	0	0	0	12033	1116	39	3	311	3	PKMYT1	16	3024073	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1164751	3024073	87330680	151	13905											
MEFV	4210	broad.mit.edu	37	chr16	3293683	3293683	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaagcggtttctgcatccaGaatcacattaactgcaaaga	14	10	8	9	1	2	2	1	0	1	2	3	2	3	2	1	1	4	4	1	1	4	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr16:3293683G>T	uc002cun.1	-	10	1844	c.1804C>A	c.(1804-1806)CTG>ATG	p.L602M		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	602	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	TCTGCATCCAGAATCACATTA	0.498													64	375					5.82089e-37	6.61581e-37	1	0	T	3293683	T	T	3293683	3	4	68	1	0	0	0	0	1	0	0	0	9512	933	33	2	545	2	MEFV	16	3293683	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	269610	3293683	87061070	152	13906											
KIAA0430	9665	broad.mit.edu	37	chr16	15733071	15733071	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctactgcaggagttctcaGttccgtttccttccatcata	7	16	6	12	1	3	0	2	0	2	0	7	1	6	1	3	1	2	4	3	1	2	7			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr16:15733071G>T	uc002ddr.2	-	2	213	c.20C>A	c.(19-21)ACT>AAT	p.T7N	KIAA0430_uc002ddq.2_Missense_Mutation_p.T6N|KIAA0430_uc010uzv.1_Missense_Mutation_p.T6N|KIAA0430_uc010uzw.1_Missense_Mutation_p.T6N|KIAA0430_uc010uzx.1_Missense_Mutation_p.T6N	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	6						peroxisome	nucleotide binding|RNA binding				0						GGAGTTCTCAGTTCCGTTTCC	0.408													5	269					0.000602214	0.000621485	1	0	T	15733071	T	T	15733071	3	4	68	1	0	0	0	0	1	0	0	0	8216	1029	36	4	5315	4	KIAA0430	16	15733071	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	12439388	15733071	74621682	153	13907											
CYLD	1540	broad.mit.edu	37	chr16	50788321	50788321	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacaattctattgcacatcaAtgatatcatcccaggtatgt	13	14	5	9	0	3	1	2	1	1	0	4	1	4	1	1	1	2	2	1	1	6	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr16:50788321A>G	uc002egp.1	+	6	1314	c.899A>G	c.(898-900)AAT>AGT	p.N300S	CYLD_uc002egn.1_Missense_Mutation_p.N300S|CYLD_uc002ego.2_Missense_Mutation_p.N300S|CYLD_uc010cbs.1_Missense_Mutation_p.N300S|CYLD_uc002egq.1_Missense_Mutation_p.N300S|CYLD_uc002egr.1_Missense_Mutation_p.N300S|CYLD_uc002egs.1_Missense_Mutation_p.N300S	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	300	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TTGCACATCAATGATATCATC	0.269			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				8	51					0	0	0	0	G	50788321	G	G	50788321	3	3	68	1	0	0	0	0	1	0	0	0	4160	101	4	5	909	5	CYLD	16	50788321	Missense_Mutation	SNP	A	TCGA-CN-5374-01A-01D-1434-08	35055250	50788321	39566432	154	13908											
CHD9	80205	broad.mit.edu	37	chr16	53243560	53243560	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catagcaaaagcaaaggagcGtggggaacgcaatattccac	16	5	11	9	2	0	0	0	0	0	0	1	2	1	2	1	3	4	3	1	3	7	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr16:53243560G>A	uc002ehb.2	+	2	1783	c.1619G>A	c.(1618-1620)CGT>CAT	p.R540H	CHD9_uc002egy.2_Missense_Mutation_p.R540H|CHD9_uc002egz.1_Missense_Mutation_p.R540H|CHD9_uc002eha.1_Missense_Mutation_p.R540H|CHD9_uc002ehc.2_Missense_Mutation_p.R540H|CHD9_uc002ehd.2_Missense_Mutation_p.R66H	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	540					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				GCAAAGGAGCGTGGGGAACGC	0.418													29	90					0	0	0	0	A	53243560	A	A	53243560	3	1	68	1	0	0	0	0	1	0	0	0	3347	1145	40	1	1625	1	CHD9	16	53243560	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	2455239	53243560	37111193	155	13909											
KCTD19	146212	broad.mit.edu	37	chr16	67325248	67325248	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggagaccaccttggctgtGatggctttggggtccttttg	5	13	15	8	0	0	2	0	1	0	1	1	3	1	2	3	5	0	2	3	5	0	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr16:67325248G>A	uc002esu.2	-	14	2580	c.2529C>T	c.(2527-2529)ATC>ATT	p.I843I	KCTD19_uc002est.2_Silent_p.I615I|KCTD19_uc010vjj.1_Silent_p.I586I	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	843						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CCTTGGCTGTGATGGCTTTGG	0.557													9	63					0	0	0	0	A	67325248	A	A	67325248	2	1	68	1	0	0	0	0	0	0	0	1	8145	1280	45	2		2	KCTD19	16	67325248	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	14081688	67325248	23029505	156	13910											
HYDIN	54768	broad.mit.edu	37	chr16	70902676	70902676	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tatgtccttggcacacccagGgtggaggtggcccatctagg	7	9	14	11	0	1	0	0	0	1	0	2	1	2	1	3	6	0	1	3	6	2	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr16:70902676G>A	uc002ezr.2	-	66	11232	c.11104C>T	c.(11104-11106)CCT>TCT	p.P3702S	HYDIN_uc010cfy.2_5'Flank	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3703										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GCACACCCAGGGTGGAGGTGG	0.463													13	33					0	0	0	0	A	70902676	A	A	70902676	3	1	68	1	0	0	0	0	1	0	0	0	7506	1232	43	4	4342	4	HYDIN	16	70902676	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	3577428	70902676	19452077	157	13911											
CHST6	4166	broad.mit.edu	37	chr16	75512869	75512869	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcccagtgaaggcgtagagCgcacggatttctgccagcgg	9	6	15	11	4	1	2	0	1	1	1	1	3	1	3	2	3	4	2	2	3	2	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr16:75512869C>T	uc002fef.2	-	3	1038	c.858G>A	c.(856-858)GCG>GCA	p.A286A	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.A286A	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	286	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGGCGTAGAGCGCACGGATTT	0.672													8	64					0	0	0	0	T	75512869	T	T	75512869	2	4	68	1	0	0	0	0	0	0	0	1	3423	755	27	1		1	CHST6	16	75512869	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	4610193	75512869	14841884	158	13912											
TAF1C	9013	broad.mit.edu	37	chr16	84214952	84214952	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctgagtgtccagcatcttCactccggtgcggtcacccac	7	9	9	16	2	3	1	2	1	1	0	5	1	5	1	4	2	2	1	4	2	0	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr16:84214952C>T	uc002fhn.2	-	10	1452	c.1224G>A	c.(1222-1224)GTG>GTA	p.V408V	TAF1C_uc002fhm.2_Silent_p.V315V|TAF1C_uc010vnx.1_Silent_p.V382V|TAF1C_uc010vny.1_5'UTR|TAF1C_uc010vnz.1_Silent_p.V76V|TAF1C_uc002fho.2_5'UTR|TAF1C_uc010voa.1_Silent_p.V76V|TAF1C_uc002fhp.1_Intron|TAF1C_uc010vob.1_3'UTR	NM_005679	NP_005670	Q15572	TAF1C_HUMAN	TBP-associated factor 1C isoform 1	408					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			ovary(1)	1						CCAGCATCTTCACTCCGGTGC	0.697													19	29					0	0	0	0	T	84214952	T	T	84214952	2	4	68	1	0	0	0	0	0	0	0	1	15587	813	29	2		2	TAF1C	16	84214952	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	8702083	84214952	6139801	159	13913											
DHX33	56919	broad.mit.edu	37	chr17	5353646	5353646	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgccgggaaggagggttgtgGaggacgctgtccacagacag	9	5	18	9	3	0	1	0	0	0	1	1	5	1	5	2	5	0	2	2	5	1	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr17:5353646G>T	uc002gca.2	-	10	1607	c.1605C>A	c.(1603-1605)CTC>CTA	p.L535L	DHX33_uc002gbz.2_Silent_p.L306L|DHX33_uc002gcb.2_Silent_p.L362L|DHX33_uc010clf.2_Silent_p.L311L	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	535						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						GAGGGTTGTGGAGGACGCTGT	0.522													8	294					2.74318e-10	2.96126e-10	1	0	T	5353646	T	T	5353646	2	4	68	1	0	0	0	0	0	0	0	1	4528	1161	41	2		2	DHX33	17	5353646	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08		5353646	75841564	160	13914											
DHX33	56919	broad.mit.edu	37	chr17	5364405	5364405	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgagagaacaggtccacatCcatcgtagctgacatcacaa	14	7	8	12	1	1	3	1	2	0	1	4	4	3	3	2	1	2	2	2	1	3	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr17:5364405C>A	uc002gca.2	-	4	705	c.703G>T	c.(703-705)GAT>TAT	p.D235Y	DHX33_uc002gbz.2_Missense_Mutation_p.D6Y|DHX33_uc002gcb.2_Missense_Mutation_p.D62Y|DHX33_uc010clf.2_Intron	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	235	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						AGGTCCACATCCATCGTAGCT	0.517													36	185					1.90571e-15	2.10117e-15	1	0	A	5364405	A	A	5364405	3	1	68	1	0	0	0	0	1	0	0	0	4528	855	30	2	1456	2	DHX33	17	5364405	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	10759	5364405	75830805	161	13915											
KCTD11	147040	broad.mit.edu	37	chr17	7256895	7256895	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgagcacggcttccgactaGactctgtcttccccgacccc	6	9	8	18	4	2	1	0	0	2	1	5	4	4	1	5	1	1	2	5	1	1	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr17:7256895G>C	uc002gge.3	+	1	1688	c.634G>C	c.(634-636)GAC>CAC	p.D212H	TMEM95_uc002ggf.1_5'Flank|TMEM95_uc002ggg.1_5'Flank|TMEM95_uc002ggh.1_5'Flank	NM_001002914	NP_001002914	Q693B1	KCD11_HUMAN	potassium channel tetramerisation domain	212					cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Prostate(122;0.157)				CTTCCGACTAGACTCTGTCTT	0.642													4	65					0	0	0	0	C	7256895	C	C	7256895	3	2	68	1	0	0	0	0	1	0	0	0	8137	942	33	2	636	2	KCTD11	17	7256895	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1892490	7256895	73938315	162	13916											
TEKT3	64518	broad.mit.edu	37	chr17	15217494	15217494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcgtcgatccggtaagccGtctgtttgtcactcaggtcc	5	13	11	12	4	3	0	2	0	1	0	7	1	5	0	3	2	1	2	3	2	1	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr17:15217494G>A	uc002gon.2	-	6	975	c.788C>T	c.(787-789)ACG>ATG	p.T263M		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	263					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		CCGGTAAGCCGTCTGTTTGTC	0.557													11	64					0	0	0	0	A	15217494	A	A	15217494	3	1	68	1	0	0	0	0	1	0	0	0	15820	1145	40	1	700	1	TEKT3	17	15217494	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	7960599	15217494	65977716	163	13917											
RAI1	10743	broad.mit.edu	37	chr17	17701461	17701461	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcacctgtgaggaggcctcGctgccgcttgagagaacact	8	7	14	12	2	0	3	0	2	0	1	1	5	0	4	3	3	2	3	3	3	1	1	rs146112263	byFrequency	TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr17:17701461G>A	uc002grm.2	+	3	5668	c.5199G>A	c.(5197-5199)TCG>TCA	p.S1733S	RAI1_uc002grn.1_Silent_p.S1733S	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1733						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		AGGAGGCCTCGCTGCCGCTTG	0.642													10	49					0	0	0	0	A	17701461	A	A	17701461	2	1	68	1	0	0	0	0	0	0	0	1	13072	1074	38	1		1	RAI1	17	17701461	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	2483967	17701461	63493749	164	13918											
PTRH2	51651	broad.mit.edu	37	chr17	57775025	57775025	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacagtattcccattgtttGagcatttcaggatttcttct	8	17	6	10	0	3	1	1	1	2	0	4	2	4	2	2	1	1	3	2	1	1	7			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr17:57775025G>C	uc002ixt.2	-	2	440	c.315C>G	c.(313-315)CTC>CTG	p.L105L	PTRH2_uc002ixs.2_RNA	NM_016077	NP_057161	Q9Y3E5	PTH2_HUMAN	Bcl-2 inhibitor of transcription precursor	105					apoptosis|translation	mitochondrion	aminoacyl-tRNA hydrolase activity				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CCCATTGTTTGAGCATTTCAG	0.463													11	242					0	0	0	0	C	57775025	C	C	57775025	2	2	68	1	0	0	0	0	0	0	0	1	12882	1277	45	2		2	PTRH2	17	57775025	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	40073564	57775025	23420185	165	13919											
COG1	9382	broad.mit.edu	37	chr17	71193179	71193179	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagacttcctgctggccaGaaaggcaactattcagaaac	14	7	8	12	0	1	3	1	0	0	3	2	3	2	3	2	2	3	2	2	2	4	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr17:71193179G>A	uc002jjg.2	+	3	737	c.701G>A	c.(700-702)AGA>AAA	p.R234K	COG1_uc002jjh.2_Missense_Mutation_p.R234K|COG1_uc002jjf.1_Missense_Mutation_p.R234K	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	234					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			CTGCTGGCCAGAAAGGCAACT	0.522													6	54					0	0	0	0	A	71193179	A	A	71193179	3	1	68	1	0	0	0	0	1	0	0	0	3672	942	33	2	711	2	COG1	17	71193179	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	13418154	71193179	10002031	166	13920											
BAHCC1	57597	broad.mit.edu	37	chr17	79428095	79428095	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaagaagctgcgggcccgcGaggccctgttccccgtgcac	6	5	14	16	4	0	1	0	0	0	1	1	2	1	1	4	2	3	4	4	2	2	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr17:79428095G>A	uc002kaf.2	+	24	6406	c.6406G>A	c.(6406-6408)GAG>AAG	p.E2136K	BAHCC1_uc002kae.2_Missense_Mutation_p.E1366K	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	2136							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GCGGGCCCGCGAGGCCCTGTT	0.682													4	18					0	0	0	0	A	79428095	A	A	79428095	3	1	68	1	0	0	0	0	1	0	0	0	1298	1059	37	1	6339	1	BAHCC1	17	79428095	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	8234916	79428095	1767115	167	13921											
MC2R	4158	broad.mit.edu	37	chr18	13885287	13885287	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaggatattttccaagatCttatataggctgcccagcat	12	13	7	9	0	2	1	1	0	1	1	3	2	3	2	2	2	2	2	2	2	5	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr18:13885287C>T	uc002ksp.1	-	2	408	c.231G>A	c.(229-231)AAG>AAA	p.K77K		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	77	Helical; Name=2; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	TTTCCAAGATCTTATATAGGC	0.448													6	108					0	0	0	0	T	13885287	T	T	13885287	2	4	68	1	0	0	0	0	0	0	0	1	9417	912	32	2		2	MC2R	18	13885287	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08		13885287	64191961	168	13922											
CDH19	28513	broad.mit.edu	37	chr18	64239324	64239324	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccagccacgcttcactcTcaaatgagatcgcactggct	10	8	7	16	2	2	1	2	1	1	1	4	2	2	1	2	1	1	3	2	1	1	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr18:64239324T>A	uc002lkc.1	-	2	256	c.118A>T	c.(118-120)AGA>TGA	p.R40*	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Nonsense_Mutation_p.R40*|CDH19_uc002lkd.2_Nonsense_Mutation_p.R40*	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	40					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CGCTTCACTCTCAAATGAGAT	0.423													20	113					0	0	0	0	A	64239324	A	A	64239324	4	1	68	1	0	0	0	0	0	1	0	0	3119	1559	54	5	2244	5	CDH19	18	64239324	Nonsense_Mutation	SNP	T	TCGA-CN-5374-01A-01D-1434-08	50354037	64239324	13837924	169	13923											
TMPRSS9	360200	broad.mit.edu	37	chr19	2408478	2408478	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccctgtacaacgcggacacgGccgactttgacgtggctgtg	7	8	13	13	5	0	1	0	1	0	0	0	3	0	2	2	3	2	2	2	3	2	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:2408478G>A	uc010xgx.1	+	7	865	c.865G>A	c.(865-867)GCC>ACC	p.A289T	TMPRSS9_uc002lvv.1_Missense_Mutation_p.A323T	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	289	Extracellular (Potential).|Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCGGACACGGCCGACTTTGA	0.677													4	162					0	0	0	0	A	2408478	A	A	2408478	3	1	68	1	0	0	0	0	1	0	0	0	16319	1203	42	4	891	4	TMPRSS9	19	2408478	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08		2408478	56720505	170	13924											
FBN3	84467	broad.mit.edu	37	chr19	8156457	8156457	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggcagaggttgggctcctCtgagcactcgtcgatatctg	7	10	14	10	2	2	2	0	1	2	1	5	4	3	2	1	3	1	4	1	3	1	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:8156457C>G	uc002mjf.2	-	47	5944	c.5923G>C	c.(5923-5925)GAG>CAG	p.E1975Q	FBN3_uc002mje.2_5'Flank	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1975	EGF-like 32; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TTGGGCTCCTCTGAGCACTCG	0.602													16	95					0	0	0	0	G	8156457	G	G	8156457	3	3	68	1	0	0	0	0	1	0	0	0	5736	922	32	2	2574	2	FBN3	19	8156457	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	5747979	8156457	50972526	171	13925											
MUC16	94025	broad.mit.edu	37	chr19	9067136	9067136	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atttctgagtgtggaaattcCtgagtcgccatcgagtgtgt	8	14	12	7	2	1	2	0	2	1	0	4	4	2	3	2	1	0	0	2	1	1	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:9067136C>T	uc002mkp.2	-	3	20514	c.20310G>A	c.(20308-20310)CAG>CAA	p.Q6770Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6772	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGAAATTCCTGAGTCGCCA	0.488													125	201					0	0	0	0	T	9067136	T	T	9067136	2	4	68	1	0	0	0	0	0	0	0	1	10026	680	24	4		4	MUC16	19	9067136	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	910679	9067136	50061847	172	13926											
MUC16	94025	broad.mit.edu	37	chr19	9076191	9076191	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtggccccctgaggagctGaggtagtggctgtggctgat	5	11	17	8	0	0	3	0	3	0	0	0	4	0	4	2	5	1	4	2	5	1	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:9076191G>A	uc002mkp.2	-	3	11459	c.11255C>T	c.(11254-11256)TCA>TTA	p.S3752L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3753	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGAGGAGCTGAGGTAGTGGC	0.522													34	66					0	0	0	0	A	9076191	A	A	9076191	3	1	68	1	0	0	0	0	1	0	0	0	10026	1294	45	2	32596	2	MUC16	19	9076191	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	9055	9076191	50052792	173	13927											
WIZ	58525	broad.mit.edu	37	chr19	15547866	15547866	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggcgtggctggagaggcCggcccgtgtgtcgaagccag	5	5	19	12	5	0	1	0	0	0	1	1	3	0	1	4	5	1	1	4	5	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:15547866C>T	uc002nbb.3	-	3	494	c.280G>A	c.(280-282)GGC>AGC	p.G94S		NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	884	C2H2-type 7.					nucleus	zinc ion binding				0						CTGGAGAGGCCGGCCCGTGTG	0.632													6	25					0	0	0	0	T	15547866	T	T	15547866	3	4	68	1	0	0	0	0	1	0	0	0	17443	652	23	1	2128	1	WIZ	19	15547866	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	6471675	15547866	43581117	174	13928											
HAUS8	93323	broad.mit.edu	37	chr19	17173586	17173586	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgtgacccatctcctgcagGagcctgttatgggaacacat	9	10	10	12	0	1	1	0	1	1	0	2	3	1	3	3	2	3	2	3	2	2	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:17173586G>A	uc002nfe.2	-	4	262	c.151C>T	c.(151-153)CCT>TCT	p.P51S	HAUS8_uc002nff.2_Missense_Mutation_p.P51S|HAUS8_uc002nfg.1_5'UTR|HAUS8_uc002nfh.1_Missense_Mutation_p.P51S	NM_033417	NP_219485	Q9BT25	HAUS8_HUMAN	sarcoma antigen NY-SAR-48 isoform a	51					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0						TCTCCTGCAGGAGCCTGTTAT	0.532													13	88					0	0	0	0	A	17173586	A	A	17173586	3	1	68	1	0	0	0	0	1	0	0	0	7011	1174	41	2	1113	2	HAUS8	19	17173586	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1625720	17173586	41955397	175	13929											
KIAA0892	23383	broad.mit.edu	37	chr19	19465201	19465201	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgcctgccatgcagctcgCcagcaagatcccggacatgt	8	7	12	14	2	0	1	0	0	0	1	2	2	1	2	4	2	5	3	4	2	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:19465201C>T	uc002nmk.3	+	17	1625	c.1586C>T	c.(1585-1587)GCC>GTC	p.A529V	KIAA0892_uc002nml.3_Missense_Mutation_p.A134V|KIAA0892_uc010ecd.2_Missense_Mutation_p.A134V|KIAA0892_uc010ece.2_Missense_Mutation_p.A105V	NM_015329	NP_056144	Q9Y6X3	SCC4_HUMAN	hypothetical protein LOC23383 precursor	529	TPR 4.				cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding				0						ATGCAGCTCGCCAGCAAGATC	0.627													9	74					0	0	0	0	T	19465201	T	T	19465201	3	4	68	1	0	0	0	0	1	0	0	0	8235	739	26	4	1652	4	KIAA0892	19	19465201	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	2291615	19465201	39663782	176	13930											
ZNF430	80264	broad.mit.edu	37	chr19	21240159	21240159	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaaccctacaaatgtgaaGaatgtggcaaagcttttaac	17	9	8	7	0	0	3	0	1	0	2	0	3	0	3	1	1	4	2	1	1	7	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:21240159G>A	uc002npj.2	+	5	1155	c.1045G>A	c.(1045-1047)GAA>AAA	p.E349K	ZNF430_uc002npk.2_Missense_Mutation_p.E348K	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	349	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						CAAATGTGAAGAATGTGGCAA	0.393													56	98					0	0	0	0	A	21240159	A	A	21240159	3	1	68	1	0	0	0	0	1	0	0	0	17971	943	33	2	1063	2	ZNF430	19	21240159	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1774958	21240159	37888824	177	13931											
ZNF492	57615	broad.mit.edu	37	chr19	22817248	22817248	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggagatccacagctaagaCgctaggaccccctggaagcc	11	5	12	13	1	0	2	0	0	0	2	1	5	1	4	4	3	2	2	4	3	3	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:22817248C>T	uc002nqw.3	+	1	123	c.-121C>T	c.(-123--119)GACGC>GATGC			NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				ACAGCTAAGACGCTAGGACCC	0.607													23	105					0	0	0	0	T	22817248	T	T	22817248	1	4	68	1	0	0	0	0	0	0	0	0	18010	551	19	1		1	ZNF492	19	22817248	Translation_Start_Site	SNP	C	TCGA-CN-5374-01A-01D-1434-08	1577089	22817248	36311735	178	13932											
PDCD2L	84306	broad.mit.edu	37	chr19	34912449	34912449	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctggagtggagagccactcTttttgacctgccctacatca	8	11	9	13	0	2	2	1	1	1	1	2	4	2	3	4	2	3	0	4	2	1	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:34912449T>A	uc002nvj.2	+	6	856	c.823T>A	c.(823-825)TTT>ATT	p.F275I		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	275						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			AGAGCCACTCTTTTTGACCTG	0.512													16	378					0	0	0	0	A	34912449	A	A	34912449	3	1	68	1	0	0	0	0	1	0	0	0	11674	1609	56	5	845	5	PDCD2L	19	34912449	Missense_Mutation	SNP	T	TCGA-CN-5374-01A-01D-1434-08	12095201	34912449	24216534	179	13933											
ZBTB32	27033	broad.mit.edu	37	chr19	36205789	36205789	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagtgtagagctgcagccTggagagctaaggccccttca	10	7	14	10	0	1	3	1	0	0	3	1	5	1	3	3	2	4	4	3	2	2	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:36205789T>C	uc002oay.2	+	2	471	c.261T>C	c.(259-261)CCT>CCC	p.P87P	ZBTB32_uc002oaz.2_RNA	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	87	BTB.				DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGCTGCAGCCTGGAGAGCTAA	0.627													3	150					0	0	0	0	C	36205789	C	C	36205789	2	2	68	1	0	0	0	0	0	0	0	1	17602	1567	55	5		5	ZBTB32	19	36205789	Silent	SNP	T	TCGA-CN-5374-01A-01D-1434-08	1293340	36205789	22923194	180	13934											
ZNF780A	284323	broad.mit.edu	37	chr19	40580486	40580486	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agctgggtgggaagactaaaAacctttccacattccttaca	13	10	8	10	0	0	1	0	0	0	1	2	2	2	2	3	2	3	1	3	2	5	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:40580486A>G	uc002omy.2	-	6	2088	c.1863T>C	c.(1861-1863)GTT>GTC	p.V621V	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Silent_p.V621V|ZNF780A_uc010xvh.1_Silent_p.V622V	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	621	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GAAGACTAAAAACCTTTCCAC	0.413													39	166					0	0	0	0	G	40580486	G	G	40580486	2	3	68	1	0	0	0	0	0	0	0	1	18219	1	1	5		5	ZNF780A	19	40580486	Silent	SNP	A	TCGA-CN-5374-01A-01D-1434-08	4374697	40580486	18548497	181	13935											
ZNF155	7711	broad.mit.edu	37	chr19	44500287	44500287	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggagtctgttccagaagcagGagcacatgaagagtggtcct	11	8	14	8	0	1	3	0	1	1	2	3	5	3	5	2	3	2	3	2	3	2	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:44500287G>A	uc002oxy.1	+	5	483	c.278G>A	c.(277-279)GGA>GAA	p.G93E	ZNF155_uc002oxz.1_Missense_Mutation_p.G93E|ZNF155_uc010xwt.1_Missense_Mutation_p.G104E	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	93						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				CCAGAAGCAGGAGCACATGAA	0.418													22	120					0	0	0	0	A	44500287	A	A	44500287	3	1	68	1	0	0	0	0	1	0	0	0	17803	1174	41	2	292	2	ZNF155	19	44500287	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	3919801	44500287	14628696	182	13936											
SYMPK	8189	broad.mit.edu	37	chr19	46324705	46324705	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtaatgcgatcaggagctCtccagggttcagcggggaca	9	8	15	9	2	3	0	2	0	1	0	4	3	3	2	1	4	3	3	1	4	1	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:46324705C>T	uc002pdn.2	-	22	3075	c.2830G>A	c.(2830-2832)GAG>AAG	p.E944K	SYMPK_uc002pdo.1_Missense_Mutation_p.E944K|SYMPK_uc002pdp.1_Missense_Mutation_p.E944K	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	944					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		ATCAGGAGCTCTCCAGGGTTC	0.587													3	61					0	0	0	0	T	46324705	T	T	46324705	3	4	68	1	0	0	0	0	1	0	0	0	15505	922	32	2	1018	2	SYMPK	19	46324705	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	1824418	46324705	12804278	183	13937											
TRPM4	54795	broad.mit.edu	37	chr19	49693515	49693515	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggccagcactacacccatCtgggccctggttctcgcctt	6	10	9	16	1	2	0	0	0	2	0	3	0	2	0	4	3	2	2	4	3	1	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:49693515C>G	uc002pmw.2	+	15	2142	c.2070C>G	c.(2068-2070)ATC>ATG	p.I690M	TRPM4_uc010emu.2_Missense_Mutation_p.I690M|TRPM4_uc010yak.1_Missense_Mutation_p.I154M|TRPM4_uc002pmx.2_Missense_Mutation_p.I516M|TRPM4_uc010emv.2_Missense_Mutation_p.I575M|TRPM4_uc010yal.1_Missense_Mutation_p.I336M|TRPM4_uc002pmy.2_Missense_Mutation_p.I32M	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	690	Helical; (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CTACACCCATCTGGGCCCTGG	0.602													53	364					0	0	0	0	G	49693515	G	G	49693515	3	3	68	1	0	0	0	0	1	0	0	0	16655	903	32	2	2128	2	TRPM4	19	49693515	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	3368810	49693515	9435468	184	13938											
C19orf41	126123	broad.mit.edu	37	chr19	50666297	50666297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcagcacggccccggcgCgcgcctgcagctgctccaac	6	4	11	20	5	1	0	1	0	0	0	2	0	2	0	5	2	5	4	5	2	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:50666297C>T	uc002prp.1	-	1	242	c.155G>A	c.(154-156)CGC>CAC	p.R52H		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	52	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		GGCCCCGGCGCGCGCCTGCAG	0.667													5	51					0	0	0	0	T	50666297	T	T	50666297	3	4	68	1	0	0	0	0	1	0	0	0	1933	768	27	1	538	1	C19orf41	19	50666297	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	972782	50666297	8462686	185	13939											
ZNF761	388561	broad.mit.edu	37	chr19	53958797	53958797	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caatccttacacgccatcatCgacttcatactggagagaaa	14	9	6	12	2	2	1	2	0	0	1	4	4	3	2	2	1	2	0	2	1	4	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:53958797C>T	uc010eqp.2	+	7	1494	c.1036C>T	c.(1036-1038)CGA>TGA	p.R346*	ZNF761_uc010ydy.1_Nonsense_Mutation_p.R292*|ZNF761_uc002qbt.1_Nonsense_Mutation_p.R292*	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	346	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		ACGCCATCATCGACTTCATAC	0.403													49	198					0	0	0	0	T	53958797	T	T	53958797	4	4	68	1	0	0	0	0	0	1	0	0	18203	876	31	1	1047	1	ZNF761	19	53958797	Nonsense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	3292500	53958797	5170186	186	13940											
CACNG7	59284	broad.mit.edu	37	chr19	54445546	54445546	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catctccacctcgccctgctGaggcccgcccctcggagctc	4	7	9	21	3	1	1	0	1	1	0	5	2	1	2	6	2	2	2	6	2	0	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:54445546G>A	uc002qcr.1	+	5	842	c.827G>A	c.(826-828)TGA>TAA	p.*276*		NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	276					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		TCGCCCTGCTGAGGCCCGCCC	0.662													48	209					0	0	0	0	A	54445546	A	A	54445546	2	1	68	1	0	0	0	0	0	0	0	1	2574	1285	45	2		2	CACNG7	19	54445546	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	486749	54445546	4683437	187	13941											
ZNF550	162972	broad.mit.edu	37	chr19	58059066	58059066	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgctgtgagtcacattcatgGagaacatctgctgataacca	12	11	9	9	0	3	3	2	2	1	1	3	4	3	3	1	1	4	2	1	1	2	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr19:58059066G>T	uc002qpe.1	-	2	423	c.423C>A	c.(421-423)CTC>CTA	p.L141L	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF550_uc002qpc.2_RNA|ZNF550_uc010eue.1_RNA|ZNF550_uc002qpd.2_RNA	NM_001039654	NP_001034743	Q7Z398	ZN550_HUMAN	zinc finger protein 550	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CACATTCATGGAGAACATCTG	0.483													15	363					6.72482e-11	7.28993e-11	1	0	T	58059066	T	T	58059066	2	4	68	1	0	0	0	0	0	0	0	1	18049	1161	41	2		2	ZNF550	19	58059066	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	3613520	58059066	1069917	188	13942											
GGT7	2686	broad.mit.edu	37	chr20	33444646	33444646	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaggcttctccacaagggcGctgtaattgctgaagtcctc	9	10	10	12	1	1	1	0	1	1	0	4	1	2	1	2	2	1	4	2	2	3	3	rs3746452		TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr20:33444646G>A	uc002xay.2	-	8	1108	c.1065C>T	c.(1063-1065)AGC>AGT	p.S355S	GGT7_uc002xaz.1_Silent_p.S372S	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	355	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						CCACAAGGGCGCTGTAATTGC	0.602													4	32					0	0	0	0	A	33444646	A	A	33444646	2	1	68	1	0	0	0	0	0	0	0	1	6401	1078	38	1		1	GGT7	20	33444646	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08		33444646	29580874	189	13943											
TOP1	7150	broad.mit.edu	37	chr20	39744053	39744053	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatggagaacaagcagcccGaggatgatctttttgataga	13	11	11	6	1	1	4	0	2	1	2	1	7	1	5	1	2	3	1	1	2	4	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr20:39744053G>T	uc002xjl.2	+	16	1927	c.1681G>T	c.(1681-1683)GAG>TAG	p.E561*	uc002xjn.1_Intron	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	561					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	CAAGCAGCCCGAGGATGATCT	0.378			T	NUP98	AML*								19	121					8.04996e-18	8.91369e-18	1	0	T	39744053	T	T	39744053	4	4	68	1	0	0	0	0	0	1	0	0	16430	1059	37	3	1743	3	TOP1	20	39744053	Nonsense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	6299407	39744053	23281467	190	13944											
L3MBTL	26013	broad.mit.edu	37	chr20	42163513	42163513	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctatgatttctggatcgacGctgaccacccagacatccac	10	9	8	14	2	1	3	0	2	1	1	3	5	2	4	3	1	0	2	3	1	1	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr20:42163513G>A	uc010zwh.1	+	16	1736	c.1690G>A	c.(1690-1692)GCT>ACT	p.A564T	L3MBTL_uc002xkl.2_Missense_Mutation_p.A496T|L3MBTL_uc002xkm.2_Missense_Mutation_p.A496T|L3MBTL_uc010ggl.2_Missense_Mutation_p.A496T|L3MBTL_uc002xkn.1_Missense_Mutation_p.A255T|L3MBTL_uc002xko.2_Missense_Mutation_p.A148T	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	496	MBT 3.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CTGGATCGACGCTGACCACCC	0.577													5	44					0	0	0	0	A	42163513	A	A	42163513	3	1	68	1	0	0	0	0	1	0	0	0	8631	1087	38	1	1536	1	L3MBTL	20	42163513	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	2419460	42163513	20862007	191	13945											
KCNK15	60598	broad.mit.edu	37	chr20	43379005	43379005	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgccgccaccctggccctCggggccgtcgccttctcgca	2	8	12	19	5	1	0	0	0	1	0	4	0	1	0	6	3	1	1	6	3	0	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr20:43379005C>T	uc002xmr.2	+	2	583	c.519C>T	c.(517-519)CTC>CTT	p.L173L		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	173	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				CCCTGGCCCTCGGGGCCGTCG	0.672													12	53					0	0	0	0	T	43379005	T	T	43379005	2	4	68	1	0	0	0	0	0	0	0	1	8101	871	31	1		1	KCNK15	20	43379005	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	1215492	43379005	19646515	192	13946											
WFDC8	90199	broad.mit.edu	37	chr20	44180733	44180733	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccaccaatgggcactcctCatcctgcaggcacttgggtt	7	11	9	14	0	1	0	1	0	0	0	4	0	4	0	4	3	1	4	4	3	1	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr20:44180733C>T	uc002xow.2	-	6	737	c.658G>A	c.(658-660)GAG>AAG	p.E220K	WFDC8_uc002xox.2_Missense_Mutation_p.E220K	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	220	WAP 3.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GGGCACTCCTCATCCTGCAGG	0.423													8	305					0	0	0	0	T	44180733	T	T	44180733	3	4	68	1	0	0	0	0	1	0	0	0	17424	835	29	2	71	2	WFDC8	20	44180733	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	801728	44180733	18844787	193	13947											
ARFGEF2	10564	broad.mit.edu	37	chr20	47639640	47639640	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtggtccagttggaattGatacagaccattgacaacat	12	12	10	7	0	0	3	0	2	0	1	1	4	1	4	2	2	2	1	2	2	3	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr20:47639640G>T	uc002xtx.3	+	35	4829	c.4677G>T	c.(4675-4677)TTG>TTT	p.L1559F	ARFGEF2_uc010zyf.1_Missense_Mutation_p.L852F	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1559					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AGTTGGAATTGATACAGACCA	0.453													8	219					4.68919e-08	4.97865e-08	1	0	T	47639640	T	T	47639640	3	4	68	1	0	0	0	0	1	0	0	0	853	1281	45	2	4815	2	ARFGEF2	20	47639640	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	3458907	47639640	15385880	194	13948											
TSHZ2	128553	broad.mit.edu	37	chr20	51873085	51873085	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accattcacagtttgtaacaGacgtggatgaagaatagctc	14	10	9	8	1	1	3	1	1	0	2	2	4	1	4	1	1	2	3	1	1	4	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr20:51873085G>C	uc002xwo.2	+	2	4044	c.3088G>C	c.(3088-3090)GAC>CAC	p.D1030H		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	1030					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GTTTGTAACAGACGTGGATGA	0.483													7	216					0	0	0	0	C	51873085	C	C	51873085	3	2	68	1	0	0	0	0	1	0	0	0	16691	942	33	2	3094	2	TSHZ2	20	51873085	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	4233445	51873085	11152435	195	13949											
ZNF831	128611	broad.mit.edu	37	chr20	57769147	57769147	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaggggcacagttgggggggGacaagggggacaggatggcc	10	3	22	6	0	0	0	0	0	0	0	0	3	0	3	1	10	0	2	1	10	2	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr20:57769147G>A	uc002yan.2	+	1	3073	c.3073G>A	c.(3073-3075)GAC>AAC	p.D1025N		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1025						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GTTGGGGGGGGACAAGGGGGA	0.682													6	71					0	0	0	0	A	57769147	A	A	57769147	3	1	68	1	0	0	0	0	1	0	0	0	18252	1174	41	2	3075	2	ZNF831	20	57769147	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	5896062	57769147	5256373	196	13950											
PRPF6	24148	broad.mit.edu	37	chr20	62616302	62616302	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcttctcaagtggaccctacGagaaagatgatgaggaagca	14	8	11	8	1	2	4	1	2	2	2	3	7	2	6	1	2	2	1	1	2	4	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr20:62616302G>A	uc002yho.2	+	3	451	c.283G>A	c.(283-285)GAG>AAG	p.E95K	PRPF6_uc002yhp.2_Missense_Mutation_p.E95K	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	95					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					TGGACCCTACGAGAAAGATGA	0.448													14	63					0	0	0	0	A	62616302	A	A	62616302	3	1	68	1	0	0	0	0	1	0	0	0	12636	1059	37	1	293	1	PRPF6	20	62616302	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	4847155	62616302	409218	197	13951											
DONSON	29980	broad.mit.edu	37	chr21	34956969	34956969	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttccagccatttttctatCagctccaatacgagggaaca	11	12	6	12	1	2	0	1	0	1	0	4	2	4	1	3	1	4	1	3	1	4	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr21:34956969C>T	uc002ysk.2	-	4	779	c.712G>A	c.(712-714)GAT>AAT	p.D238N	DONSON_uc002ysn.1_Missense_Mutation_p.D121N|DONSON_uc002ysi.1_5'UTR|DONSON_uc002ysj.2_5'UTR|DONSON_uc002ysl.2_5'UTR|DONSON_uc010gme.2_Missense_Mutation_p.D211N|DONSON_uc002ysm.2_Missense_Mutation_p.D238N	NM_017613	NP_060083	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	238					multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2						ATTTTTCTATCAGCTCCAATA	0.448													4	112					0	0	0	0	T	34956969	T	T	34956969	3	4	68	1	0	0	0	0	1	0	0	0	4728	826	29	2	1016	2	DONSON	21	34956969	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08		34956969	13172926	198	13952											
CYTSA	23384	broad.mit.edu	37	chr22	24718349	24718349	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgacagattgaatacttccgCtctcttctagatgagcatca	11	12	7	11	2	3	4	1	2	2	2	5	5	4	4	1	0	2	2	1	0	3	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr22:24718349C>T	uc002zzw.2	+	5	1708	c.1401C>T	c.(1399-1401)CGC>CGT	p.R467R	CYTSA_uc002zzv.3_Silent_p.R467R|CYTSA_uc011ajq.1_Silent_p.R467R	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	467					cell cycle|cell division						0						AATACTTCCGCTCTCTTCTAG	0.408													43	218					0	0	0	0	T	24718349	T	T	24718349	2	4	68	1	0	0	0	0	0	0	0	1	4226	784	28	4		4	CYTSA	22	24718349	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08		24718349	26586217	199	13953											
PIWIL3	440822	broad.mit.edu	37	chr22	25155901	25155901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgcagaggtctaaccactGggacttcctcctgcagcggc	7	8	12	14	1	1	1	0	0	1	1	3	2	3	2	3	3	4	3	3	3	1	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr22:25155901G>A	uc003abd.1	-	3	575	c.158C>T	c.(157-159)CCA>CTA	p.P53L	PIWIL3_uc011ajx.1_5'UTR|PIWIL3_uc011ajy.1_5'UTR|PIWIL3_uc010gut.1_Missense_Mutation_p.P53L	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	53					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						TCTAACCACTGGGACTTCCTC	0.567													102	613					0	0	0	0	A	25155901	A	A	25155901	3	1	68	1	0	0	0	0	1	0	0	0	12014	1348	47	4	2566	4	PIWIL3	22	25155901	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	437552	25155901	26148665	200	13954											
MYO18B	84700	broad.mit.edu	37	chr22	26286822	26286822	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagcggctacaggccttcCgggaggtccaggagctcaag	9	5	15	12	2	1	1	1	0	0	1	3	3	3	3	3	5	3	2	3	5	2	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr22:26286822C>T	uc003abz.1	+	26	4664	c.4414C>T	c.(4414-4416)CGG>TGG	p.R1472W	MYO18B_uc003aca.1_Missense_Mutation_p.R1353W|MYO18B_uc010guy.1_Missense_Mutation_p.R1354W|MYO18B_uc010guz.1_Missense_Mutation_p.R1353W|MYO18B_uc011aka.1_Missense_Mutation_p.R626W|MYO18B_uc011akb.1_Missense_Mutation_p.R985W	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1472	Potential.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						ACAGGCCTTCCGGGAGGTCCA	0.612													10	40					0	0	0	0	T	26286822	T	T	26286822	3	4	68	1	0	0	0	0	1	0	0	0	10119	643	23	1	4512	1	MYO18B	22	26286822	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	1130921	26286822	25017744	201	13955											
CARD10	29775	broad.mit.edu	37	chr22	37892475	37892475	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccttcgagtccatcagggaGgggagtgtggacccctgatt	7	9	14	11	1	1	1	1	1	0	0	3	5	2	4	4	4	0	0	4	4	0	2			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr22:37892475G>A	uc003asx.1	-	13	2043	c.2040C>T	c.(2038-2040)CCC>CCT	p.P680P	CARD10_uc003ast.1_RNA|CARD10_uc003asv.1_5'Flank|CARD10_uc011ank.1_5'UTR|CARD10_uc003asw.1_Silent_p.P394P|CARD10_uc003asy.1_Silent_p.P680P	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	680					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					CCATCAGGGAGGGGAGTGTGG	0.637													19	91					0	0	0	0	A	37892475	A	A	37892475	2	1	68	1	0	0	0	0	0	0	0	1	2656	987	35	4		4	CARD10	22	37892475	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	11605653	37892475	13412091	202	13956											
TAB1	10454	broad.mit.edu	37	chr22	39811028	39811028	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caggagcagcagccaagctgGacagatgacctgcctctctg	10	6	12	13	0	1	2	0	1	1	1	2	4	1	4	3	2	5	3	3	2	1	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr22:39811028G>T	uc003axt.2	+	2	100	c.51G>T	c.(49-51)TGG>TGT	p.W17C	TAB1_uc003axr.2_Missense_Mutation_p.W93C|TAB1_uc011aok.1_5'UTR|TAB1_uc003axu.1_Missense_Mutation_p.W17C	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	17					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						AGCCAAGCTGGACAGATGACC	0.612													9	31					2.80697e-09	2.99256e-09	1	0	T	39811028	T	T	39811028	3	4	68	1	0	0	0	0	1	0	0	0	15561	1183	41	2	57	2	TAB1	22	39811028	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	1918553	39811028	11493538	203	13957											
SAMM50	25813	broad.mit.edu	37	chr22	44360402	44360402	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tatcatcatttgtgaaattgGagatgttttcaaggccaaaa	14	14	8	5	0	3	2	3	1	0	1	3	3	3	2	1	2	0	1	1	2	5	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chr22:44360402G>C	uc003bej.2	+	3	400	c.203G>C	c.(202-204)GGA>GCA	p.G68A	PNPLA3_uc010gzm.1_RNA|SAMM50_uc011aqd.1_5'UTR	NM_015380	NP_056195	Q9Y512	SAM50_HUMAN	sorting and assembly machinery component 50	68					protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial sorting and assembly machinery complex	protein binding			skin(1)	1		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				TGTGAAATTGGAGATGTTTTC	0.408													21	151					0	0	0	0	C	44360402	C	C	44360402	3	2	68	1	0	0	0	0	1	0	0	0	13894	1174	41	2	213	2	SAMM50	22	44360402	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	4549374	44360402	6944164	204	13958											
FANCB	2187	broad.mit.edu	37	chrX	14883405	14883405	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacacacagttgcaacacatGatttttaaatgagagttttc	14	13	7	7	0	0	2	0	2	0	1	1	4	0	2	0	0	2	3	0	0	3	6			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chrX:14883405G>C	uc004cwg.1	-	3	496	c.228C>G	c.(226-228)ATC>ATG	p.I76M	FANCB_uc004cwh.1_Missense_Mutation_p.I76M	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	76					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					TGCAACACATGATTTTTAAAT	0.299								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				5	101					0	0	0	0	C	14883405	C	C	14883405	3	2	68	1	0	0	0	0	1	0	0	0	5695	1280	45	2	2383	2	FANCB	23	14883405	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08		14883405	140387155	205	13959											
RGN	9104	broad.mit.edu	37	chrX	46951163	46951163	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgaggggaagctctgggtgGcctgttacaatggaggaaga	10	8	17	6	0	1	2	0	1	1	1	1	5	1	5	1	6	2	2	1	6	4	1			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chrX:46951163G>C	uc004dgz.1	+	6	1618	c.649G>C	c.(649-651)GCC>CCC	p.A217P	RGN_uc004dha.1_Missense_Mutation_p.A217P|RGN_uc010nho.1_Missense_Mutation_p.A164P|RGN_uc010nhp.1_Missense_Mutation_p.A145P	NM_152869	NP_690608	Q15493	RGN_HUMAN	regucalcin	217					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding				0						GCTCTGGGTGGCCTGTTACAA	0.458													5	122					0	0	0	0	C	46951163	C	C	46951163	3	2	68	1	0	0	0	0	1	0	0	0	13347	1203	42	4	663	4	RGN	23	46951163	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	32067758	46951163	108319397	206	13960											
LPAR4	2846	broad.mit.edu	37	chrX	78010407	78010407	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacttccaattccaagattCaaattcaagcctcagaccca	14	10	4	13	0	3	3	3	1	0	2	5	3	5	3	4	0	1	0	4	0	4	4			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chrX:78010407C>G	uc010nme.2	+	2	446	c.41C>G	c.(40-42)TCA>TGA	p.S14*		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	14	Extracellular (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						TTCCAAGATTCAAATTCAAGC	0.448													27	125					0	0	0	0	G	78010407	G	G	78010407	4	3	68	1	0	0	0	0	0	1	0	0	8957	838	29	2	43	2	LPAR4	23	78010407	Nonsense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	31059244	78010407	77260153	207	13961											
DACH2	117154	broad.mit.edu	37	chrX	86068141	86068141	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaccttgacagggtctgctGaaagttgctttggataatgc	9	13	12	7	0	1	2	0	2	1	0	1	3	1	3	1	2	4	4	1	2	3	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chrX:86068141G>A	uc004eew.2	+	9	1568	c.1398G>A	c.(1396-1398)CTG>CTA	p.L466L	DACH2_uc004eex.2_Silent_p.L453L|DACH2_uc010nmq.2_Silent_p.L332L|DACH2_uc011mra.1_Silent_p.L299L|DACH2_uc010nmr.2_Silent_p.L247L|DACH2_uc004eey.2_Silent_p.L159L|DACH2_uc004eez.2_Silent_p.L149L	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	466	Potential.|DACHbox-C.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						AGGGTCTGCTGAAAGTTGCTT	0.363													4	22					0	0	0	0	A	86068141	A	A	86068141	2	1	68	1	0	0	0	0	0	0	0	1	4238	1277	45	2		2	DACH2	23	86068141	Silent	SNP	G	TCGA-CN-5374-01A-01D-1434-08	8057734	86068141	69202419	208	13962											
PRPS1	5631	broad.mit.edu	37	chrX	106882553	106882553	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtgaaagtgtacgtggaGaggatgtctacattgttcag	10	13	14	4	1	2	2	1	1	1	1	2	4	2	3	0	3	2	2	0	3	3	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chrX:106882553G>C	uc004ene.3	+	2	356	c.151G>C	c.(151-153)GAG>CAG	p.E51Q	PRPS1_uc010npg.2_Missense_Mutation_p.E51Q|PRPS1_uc011msj.1_Intron	NM_002764	NP_002755	P60891	PRPS1_HUMAN	phosphoribosyl pyrophosphate synthetase 1	51					5-phosphoribose 1-diphosphate biosynthetic process|hypoxanthine biosynthetic process|nervous system development|nucleoside metabolic process|purine nucleotide biosynthetic process|pyrimidine nucleotide biosynthetic process|ribonucleoside monophosphate biosynthetic process|urate biosynthetic process	cytosol	ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(3)|large_intestine(1)	4						TGTACGTGGAGAGGATGTCTA	0.348													56	289					0	0	0	0	C	106882553	C	C	106882553	3	2	68	1	0	0	0	0	1	0	0	0	12640	943	33	2	157	2	PRPS1	23	106882553	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	20814412	106882553	48388007	209	13963											
KIAA1210	57481	broad.mit.edu	37	chrX	118284511	118284511	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagagaagcgtgaaaggcaGagaagcctcgaggcgtccag	13	3	17	8	3	0	3	0	1	0	2	2	7	1	4	2	3	2	1	2	3	3	0			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chrX:118284511G>A	uc004era.3	-	1	32	c.32C>T	c.(31-33)TCT>TTT	p.S11F		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	11										ovary(4)|skin(1)	5						GTGAAAGGCAGAGAAGCCTCG	0.642													21	94					0	0	0	0	A	118284511	A	A	118284511	3	1	68	1	0	0	0	0	1	0	0	0	8253	942	33	2	5153	2	KIAA1210	23	118284511	Missense_Mutation	SNP	G	TCGA-CN-5374-01A-01D-1434-08	11401958	118284511	36986049	210	13964											
ODZ1	10178	broad.mit.edu	37	chrX	123517613	123517613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attaggcgttgtccatctgcCagcaacaacatcataatccc	12	10	6	13	1	2	0	1	0	1	0	4	0	4	0	3	1	4	2	3	1	4	3			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chrX:123517613C>T	uc004euj.2	-	29	7211	c.7147G>A	c.(7147-7149)GGC>AGC	p.G2383S	ODZ1_uc011muj.1_Missense_Mutation_p.G2389S|ODZ1_uc010nqy.2_Missense_Mutation_p.G2390S	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2383	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GTCCATCTGCCAGCAACAACA	0.413													63	131					0	0	0	0	T	123517613	T	T	123517613	3	4	68	1	0	0	0	0	1	0	0	0	10888	594	21	4	1042	4	ODZ1	23	123517613	Missense_Mutation	SNP	C	TCGA-CN-5374-01A-01D-1434-08	5233102	123517613	31752947	211	13965											
GPC3	2719	broad.mit.edu	37	chrX	132730493	132730493	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaagcggagctgattcttCacttttatcattccatcacc	10	13	7	11	1	4	1	3	1	1	0	5	3	5	3	2	2	2	1	2	2	2	5			TCGA-CN-5374-01A-01D-1434-08	TCGA-CN-5374-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	28d5a97b-3f3d-4595-9034-8491999fcf40	fc1114cb-d2aa-40d5-b507-ff3d97d7eab3	g.chrX:132730493C>T	uc004exe.1	-	7	1738	c.1548G>A	c.(1546-1548)GTG>GTA	p.V516V	GPC3_uc004exd.1_Silent_p.V388V|GPC3_uc010nrn.1_Silent_p.V539V|GPC3_uc011mvh.1_Silent_p.V500V|GPC3_uc010nro.1_Silent_p.V462V	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	516						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GCTGATTCTTCACTTTTATCA	0.418			T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				15	253					0	0	0	0	T	132730493	T	T	132730493	2	4	68	1	0	0	0	0	0	0	0	1	6637	813	29	2		2	GPC3	23	132730493	Silent	SNP	C	TCGA-CN-5374-01A-01D-1434-08	9212880	132730493	22540067	212	13966											
PRAMEF2	65122	broad.mit.edu	37	chr1	12920063	12920063	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgttcctcaggctggaacAcctccagttgcttaaaataa	11	12	8	10	0	1	0	1	0	0	0	3	1	3	1	3	2	2	4	3	2	4	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:12920063A>G	uc001aum.1	+	3	890	c.803A>G	c.(802-804)CAC>CGC	p.H268R		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	268											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGGCTGGAACACCTCCAGTTG	0.463													17	74					0	0	0	0	G	12920063	G	G	12920063	3	3	69	1	0	0	0	0	1	0	0	0	12495	159	6	5	809	5	PRAMEF2	1	12920063	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08		12920063	236330558	1	13967											
PADI2	11240	broad.mit.edu	37	chr1	17422438	17422438	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctccaccacaccatccCggtctgcgtccacatccagg	7	9	6	19	2	3	0	0	0	3	0	7	0	6	0	6	2	1	0	6	2	0	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:17422438C>G	uc001baf.2	-	4	459	c.377G>C	c.(376-378)CGG>CCG	p.R126P	PADI2_uc010ocm.1_Missense_Mutation_p.R126P|PADI2_uc001bag.1_Missense_Mutation_p.R126P	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	126					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	CACACCATCCCGGTCTGCGTC	0.612													3	50					0	0	0	0	G	17422438	G	G	17422438	3	3	69	1	0	0	0	0	1	0	0	0	11432	652	23	3	1672	3	PADI2	1	17422438	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	4502375	17422438	231828183	2	13968											
SFRS4	6429	broad.mit.edu	37	chr1	29475099	29475099	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggaccgggtctcctgattGgtgccagcattctcactctc	5	12	10	14	1	3	1	1	1	3	0	6	2	3	2	3	3	2	1	3	3	0	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:29475099G>T	uc001bro.2	-	6	1681	c.1308C>A	c.(1306-1308)ACC>ACA	p.T436T	SFRS4_uc010ofy.1_3'UTR	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	436	Arg/Ser-rich (RS domain).			TNQ -> RNE (in Ref. 1; AAA36649).	mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		TCTCCTGATTGGTGCCAGCAT	0.522													9	134					4.68919e-08	1.40403e-06	1	0	T	29475099	T	T	29475099	2	4	69	1	0	0	0	0	0	0	0	1	14244	1335	47	4		4	SFRS4	1	29475099	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	12052661	29475099	219775522	3	13969											
COL16A1	1307	broad.mit.edu	37	chr1	32165642	32165642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagatggttgggtgctcacCagtcacgttggctggcaggc	6	10	16	9	1	2	1	2	1	0	1	2	2	2	1	1	5	1	5	1	5	0	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:32165642C>T	uc001btk.1	-	3	513	c.148G>A	c.(148-150)GGC>AGC	p.G50S	COL16A1_uc001btj.1_5'Flank|COL16A1_uc001btl.3_Missense_Mutation_p.G50S	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	50	TSP N-terminal.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGTGCTCACCAGTCACGTTG	0.572													11	21					0	0	0	0	T	32165642	T	T	32165642	3	4	69	1	0	0	0	0	1	0	0	0	3688	608	21	4	4942	4	COL16A1	1	32165642	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	2690543	32165642	217084979	4	13970											
SPOCD1	90853	broad.mit.edu	37	chr1	32264059	32264059	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccaggttcctggggtccCgcaggttgaacagcaggctg	7	8	14	12	1	1	1	1	1	0	0	3	1	3	1	3	5	2	5	3	5	1	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:32264059C>T	uc001bts.1	-	8	2070	c.2012G>A	c.(2011-2013)CGG>CAG	p.R671Q	SPOCD1_uc001btt.2_5'UTR|SPOCD1_uc001btu.2_Missense_Mutation_p.R671Q|SPOCD1_uc001btv.2_Missense_Mutation_p.R164Q|SPOCD1_uc001btw.1_5'UTR	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	671	TFIIS central.		R -> W (in a breast cancer sample; somatic mutation).		transcription, DNA-dependent			p.R671W(1)		ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CCTGGGGTCCCGCAGGTTGAA	0.617													12	21					0	0	0	0	T	32264059	T	T	32264059	3	4	69	1	0	0	0	0	1	0	0	0	15144	652	23	1	1674	1	SPOCD1	1	32264059	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	98417	32264059	216986562	5	13971											
CYP4Z1	199974	broad.mit.edu	37	chr1	47564902	47564902	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtaccctgagcatcagcAgagatgccgagatgaaatca	16	6	10	9	1	2	4	2	2	0	2	2	6	2	4	2	0	4	3	2	0	3	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:47564902A>G	uc001cqu.1	+	8	1016	c.1013A>G	c.(1012-1014)CAG>CGG	p.Q338R		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	338	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						GAGCATCAGCAGAGATGCCGA	0.458													3	35					0	0	0	0	G	47564902	G	G	47564902	3	3	69	1	0	0	0	0	1	0	0	0	4211	188	7	5	1043	5	CYP4Z1	1	47564902	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08	15300843	47564902	201685719	6	13972											
MCOLN2	255231	broad.mit.edu	37	chr1	85395292	85395292	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaggactctttctgatacTcttctttgctactgcattcc	6	17	6	12	0	4	2	0	2	4	0	5	3	5	3	1	1	4	2	1	1	2	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:85395292T>A	uc001dkm.2	-	13	1854	c.1613A>T	c.(1612-1614)GAG>GTG	p.E538V	MCOLN2_uc001dkn.2_RNA	NM_153259	NP_694991	Q8IZK6	MCLN2_HUMAN	mucolipin 2	538						integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		TTTCTGATACTCTTCTTTGCT	0.438													5	20					0	0	0	0	A	85395292	A	A	85395292	3	1	69	1	0	0	0	0	1	0	0	0	9449	1551	54	5	95	5	MCOLN2	1	85395292	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	37830390	85395292	163855329	7	13973											
CCBL2	56267	broad.mit.edu	37	chr1	89426943	89426943	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgatgcaaaggtcagcaaTtacttgcagttcctctctgt	9	15	8	9	0	2	1	1	1	1	0	4	1	3	1	1	1	4	4	1	1	3	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:89426943T>C	uc001dmp.2	-	8	1071	c.694A>G	c.(694-696)ATT>GTT	p.I232V	CCBL2_uc001dmq.2_Missense_Mutation_p.I198V|CCBL2_uc001dmr.2_Missense_Mutation_p.I68V	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	232					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGGTCAGCAATTACTTGCAGT	0.363													17	85					0	0	0	0	C	89426943	C	C	89426943	3	2	69	1	0	0	0	0	1	0	0	0	2745	1493	52	5	698	5	CCBL2	1	89426943	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	4031651	89426943	159823678	8	13974											
DCLRE1B	64858	broad.mit.edu	37	chr1	114454676	114454676	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccctgtcccacagcagcAagggcacccctcttctagct	7	8	7	19	0	2	0	0	0	2	0	4	0	4	0	5	1	3	4	5	1	2	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:114454676A>G	uc001eeg.2	+	4	1633	c.1462A>G	c.(1462-1464)AAG>GAG	p.K488E	DCLRE1B_uc001eeh.2_Intron|DCLRE1B_uc001eei.2_Missense_Mutation_p.K362E	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	488					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCACAGCAGCAAGGGCACCCC	0.532								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					11	30					0	0	0	0	G	114454676	G	G	114454676	3	3	69	1	0	0	0	0	1	0	0	0	4312	131	5	5	1476	5	DCLRE1B	1	114454676	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08	25027733	114454676	134795945	9	13975											
LOC200030	200030	broad.mit.edu	37	chr1	148017591	148017591	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgaggccaacatttcaggaGgaattgagagagtcgaataa	16	7	12	6	2	1	2	1	1	0	1	2	7	1	4	1	3	1	0	1	3	4	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:148017591G>T	uc001eqf.2	-	12	1747	c.1712C>A	c.(1711-1713)CCT>CAT	p.P571H	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc009wkf.1_RNA|NBPF14_uc001eqq.2_Missense_Mutation_p.P231H|NBPF14_uc001eqs.1_Missense_Mutation_p.P110H	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	571	NBPF 3.					cytoplasm					0						CATTTCAGGAGGAATTGAGAG	0.507													15	273					2.27731e-05	0.000623836	1	0	T	148017591	T	T	148017591	3	4	69	1	0	0	0	0	1	0	0	0	8917	1000	35	4		4	LOC200030	1	148017591	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	33562915	148017591	101233030	10	13976											
FLG	2312	broad.mit.edu	37	chr1	152277266	152277266	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcggactcttggtggctctGctgatggggcccagcctgtc	3	11	15	12	1	2	1	0	1	2	0	3	2	2	2	2	5	3	2	2	5	0	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:152277266G>C	uc001ezu.1	-	3	10132	c.10096C>G	c.(10096-10098)CAG>GAG	p.Q3366E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3366	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGTGGCTCTGCTGATGGGGC	0.582									Ichthyosis				25	177					0	0	0	0	C	152277266	C	C	152277266	3	2	69	1	0	0	0	0	1	0	0	0	5954	1328	46	4	2093	4	FLG	1	152277266	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	4259675	152277266	96973355	11	13977											
LCE1C	353133	broad.mit.edu	37	chr1	152777761	152777761	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccagaactgcagcatcccCcagagctggagccacagctg	10	4	10	17	0	0	2	0	0	0	2	1	3	1	3	5	1	6	4	5	1	1	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:152777761C>A	uc001fap.1	-	2	245	c.194G>T	c.(193-195)GGG>GTG	p.G65V		NM_178351	NP_848128	Q5T751	LCE1C_HUMAN	late cornified envelope 1C	65	Gly-rich.				keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAGCATCCCCCAGAGCTGGA	0.617													7	42					2.0095e-06	5.68622e-05	1	0	A	152777761	A	A	152777761	3	1	69	1	0	0	0	0	1	0	0	0	8701	623	22	4	166	4	LCE1C	1	152777761	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	500495	152777761	96472860	12	13978											
FAM5B	57795	broad.mit.edu	37	chr1	177250578	177250578	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttaagctggccaacaatgagGtgggcaggatccagtcctcc	10	8	12	11	0	0	1	0	1	0	0	3	2	3	2	4	4	2	2	4	4	3	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:177250578G>T	uc001glf.2	+	8	2578	c.2266G>T	c.(2266-2268)GTG>TTG	p.V756L	FAM5B_uc001glg.2_Missense_Mutation_p.V651L	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	756						extracellular region		p.V756M(1)		skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CAACAATGAGGTGGGCAGGAT	0.557													5	42					1.024e-07	3.0308e-06	1	0	T	177250578	T	T	177250578	3	4	69	1	0	0	0	0	1	0	0	0	5625	1261	44	4	2292	4	FAM5B	1	177250578	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	24472817	177250578	72000043	13	13979											
RGL1	23179	broad.mit.edu	37	chr1	183895366	183895366	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtagccggaccagcttgacGttgcccaggacagctaaacg	10	6	12	13	4	0	1	0	1	0	0	0	3	0	3	3	2	5	4	3	2	3	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:183895366G>A	uc001gqo.2	+	18	2404	c.2247G>A	c.(2245-2247)ACG>ACA	p.T749T	RGL1_uc001gqm.2_Silent_p.T784T|RGL1_uc010pog.1_Silent_p.T747T|RGL1_uc010poh.1_Silent_p.T747T|RGL1_uc010poi.1_Silent_p.T720T	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	749					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						CCAGCTTGACGTTGCCCAGGA	0.502													23	32					0	0	0	0	A	183895366	A	A	183895366	2	1	69	1	0	0	0	0	0	0	0	1	13341	1132	40	1		1	RGL1	1	183895366	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	6644788	183895366	65355255	14	13980											
PLA2G4A	5321	broad.mit.edu	37	chr1	186839595	186839595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagtattcccacaagtttaCggtagtggtgttacgtgcca	9	12	10	10	2	0	0	0	0	0	0	1	0	1	0	3	2	3	4	3	2	5	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:186839595C>T	uc001gsc.2	+	3	267	c.62C>T	c.(61-63)ACG>ATG	p.T21M	PLA2G4A_uc010pos.1_Missense_Mutation_p.T21M	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	21	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	CACAAGTTTACGGTAGTGGTG	0.383													9	29					0	0	0	0	T	186839595	T	T	186839595	3	4	69	1	0	0	0	0	1	0	0	0	12056	536	19	1	68	1	PLA2G4A	1	186839595	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	2944229	186839595	62411026	15	13981											
PLA2G4A	5321	broad.mit.edu	37	chr1	186915840	186915840	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttatggctcccgacttatttGgaagcaaattttttatggga	10	16	9	6	1	0	0	0	0	0	0	1	3	1	2	1	3	1	2	1	3	5	6	rs77939449		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:186915840G>T	uc001gsc.2	+	11	1310	c.1105G>T	c.(1105-1107)GGA>TGA	p.G369*	PLA2G4A_uc010pos.1_Nonsense_Mutation_p.G309*	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	369	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	CGACTTATTTGGAAGCAAATT	0.328													10	101					9.31168e-06	0.000259217	1	0	T	186915840	T	T	186915840	4	4	69	1	0	0	0	0	0	1	0	0	12056	1349	47	4	1143	4	PLA2G4A	1	186915840	Nonsense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	76245	186915840	62334781	16	13982											
CRB1	23418	broad.mit.edu	37	chr1	197316484	197316484	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccagatatagctgtaactGcacgggtagtggattcacag	11	11	11	8	1	1	1	1	0	0	1	2	2	2	2	1	2	3	4	1	2	4	6	rs148240351		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:197316484G>A	uc001gtz.2	+	4	998	c.863G>A	c.(862-864)TGC>TAC	p.C288Y	CRB1_uc010poz.1_Missense_Mutation_p.C219Y|CRB1_uc001gty.1_Missense_Mutation_p.C288Y|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Intron|CRB1_uc010ppb.1_Missense_Mutation_p.C288Y|CRB1_uc010ppc.1_RNA	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	288	Extracellular (Potential).|EGF-like 7; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AGCTGTAACTGCACGGGTAGT	0.388													18	131					0	0	0	0	A	197316484	A	A	197316484	3	1	69	1	0	0	0	0	1	0	0	0	3863	1319	46	4	877	4	CRB1	1	197316484	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	10400644	197316484	51934137	17	13983											
WDR26	80232	broad.mit.edu	37	chr1	224607315	224607315	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgcatggctacacatcagaTacctaaaaatacaacagaga	18	7	6	10	0	1	2	1	0	0	2	1	3	1	2	1	1	5	2	1	1	7	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:224607315T>C	uc001hop.3	-	5	692	c.326A>G	c.(325-327)TAT>TGT	p.Y109C	WDR26_uc001hoq.3_Missense_Mutation_p.Y93C|WDR26_uc009xei.1_Missense_Mutation_p.Y93C	NM_025160	NP_079436	Q9H7D7	WDR26_HUMAN	WD repeat domain 26 isoform a	256						cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)		ACACATCAGATACCTAAAAAT	0.378													37	33					0	0	0	0	C	224607315	C	C	224607315	3	2	69	1	0	0	0	0	1	0	0	0	17351	1406	49	5	1258	5	WDR26	1	224607315	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	27290831	224607315	24643306	18	13984											
ARID4B	51742	broad.mit.edu	37	chr1	235346105	235346105	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtcttcagcagaactttcaGaagctagaaaataacagaaa	18	9	7	7	0	3	4	2	0	1	4	3	4	3	4	0	0	4	2	0	0	7	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:235346105G>A	uc001hwq.2	-	20	2627	c.2129C>T	c.(2128-2130)TCT>TTT	p.S710F	ARID4B_uc001hwr.2_Missense_Mutation_p.S624F|ARID4B_uc001hws.3_Missense_Mutation_p.S624F|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.S391F	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	710					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			AGAACTTTCAGAAGCTAGAAA	0.373													16	71					0	0	0	0	A	235346105	A	A	235346105	3	1	69	1	0	0	0	0	1	0	0	0	920	942	33	2	1829	2	ARID4B	1	235346105	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	10738790	235346105	13904516	19	13985											
ADSS	159	broad.mit.edu	37	chr1	244574694	244574694	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgtgttccatcctgggaGagtcttatattgaacttcaa	9	15	9	8	0	3	2	1	1	2	1	5	3	5	2	2	1	1	1	2	1	4	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:244574694G>T	uc001iaj.2	-	12	1507	c.1213C>A	c.(1213-1215)CTC>ATC	p.L405I		NM_001126	NP_001117	P30520	PURA2_HUMAN	adenylosuccinate synthase	405					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	CATCCTGGGAGAGTCTTATAT	0.343													20	133					1.28384e-07	3.75669e-06	1	0	T	244574694	T	T	244574694	3	4	69	1	0	0	0	0	1	0	0	0	347	942	33	2	165	2	ADSS	1	244574694	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	9228589	244574694	4675927	20	13986											
OR11L1	391189	broad.mit.edu	37	chr1	248004731	248004731	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatcagggaaggcagaaaGcctgtgctgacccctgtgca	11	7	12	11	0	2	2	2	1	0	1	2	3	2	3	3	2	3	3	3	2	2	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:248004731G>A	uc001idn.1	-	1	468	c.468C>T	c.(466-468)GGC>GGT	p.G156G		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AAGGCAGAAAGCCTGTGCTGA	0.577													11	48					0	0	0	0	A	248004731	A	A	248004731	2	1	69	1	0	0	0	0	0	0	0	1	10984	958	34	4		4	OR11L1	1	248004731	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	3430037	248004731	1245890	21	13987											
OR2M5	127059	broad.mit.edu	37	chr1	248308964	248308965	+	Missense_Mutation	DNP	GG	TT	TT																															cttctcctactgtgggtctcGggaaatagcccacttcttct																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:248308964_248308965GG>TT	uc010pze.1	+	1	515_516	c.515_516GG>TT	c.(514-516)CGG>CTT	p.R172L		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			TGTGGGTCTCGGGAAATAGCCC	0.426													13	191					0	0	0	0	TT	248308965	TT	TT	248308964	3	4	69	1	0	0	0	0	1	0	0	0	11067	1116	39	3	517	3	OR2M5	1	248308964	Missense_Mutation	DNP	GG	TCGA-CN-6010-01A-11D-1683-08	304233	248308964	941657	22	13988											
OR2T4	127074	broad.mit.edu	37	chr1	248525876	248525876	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggaataaggatgtcatggggGctctgaagaaaatgttaaca	15	9	13	4	0	2	2	1	1	1	1	2	4	2	4	0	4	1	2	0	4	6	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr1:248525876G>C	uc001ieh.1	+	1	994	c.994G>C	c.(994-996)GCT>CCT	p.A332P		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	332	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTCATGGGGGCTCTGAAGAA	0.413													25	109					0	0	0	0	C	248525876	C	C	248525876	3	2	69	1	0	0	0	0	1	0	0	0	11081	1203	42	4	996	4	OR2T4	1	248525876	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	216912	248525876	724745	23	13989											
TTC15	51112	broad.mit.edu	37	chr2	3405563	3405563	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagggagatgcagttaaaGacttgatgcttcgctttctg	9	12	11	9	1	1	3	0	1	1	2	2	4	1	3	1	1	2	4	1	1	2	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:3405563G>C	uc002qxm.1	+	3	1269	c.1063G>C	c.(1063-1065)GAC>CAC	p.D355H	TTC15_uc002qxn.1_Missense_Mutation_p.D355H|TTC15_uc010ewm.1_Missense_Mutation_p.D355H	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	355							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		TGCAGTTAAAGACTTGATGCT	0.378													17	135					0	0	0	0	C	3405563	C	C	3405563	3	2	69	1	0	0	0	0	1	0	0	0	16750	942	33	2	1069	2	TTC15	2	3405563	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08		3405563	239793810	24	13990											
FAM179A	165186	broad.mit.edu	37	chr2	29240047	29240047	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccatctccaagtctgccCgggagaagatgcagctgaag	11	7	11	12	1	3	3	1	1	2	2	4	4	3	3	3	1	3	2	3	1	3	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:29240047C>G	uc010ezl.2	+	9	1423	c.1072C>G	c.(1072-1074)CGG>GGG	p.R358G	FAM179A_uc010ymm.1_Missense_Mutation_p.R358G|FAM179A_uc002rmr.3_Intron	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	358							binding			ovary(3)|skin(1)	4						CAAGTCTGCCCGGGAGAAGAT	0.493													4	93					0	0	0	0	G	29240047	G	G	29240047	3	3	69	1	0	0	0	0	1	0	0	0	5533	643	23	3	1102	3	FAM179A	2	29240047	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	25834484	29240047	213959326	25	13991											
ALMS1	7840	broad.mit.edu	37	chr2	73826530	73826530	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctcttttatttttctaggtAgcaaaccatgtgatttcttc	8	20	5	8	0	3	1	0	1	3	0	5	1	3	1	1	1	2	2	1	1	4	8			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:73826530A>G	uc002sje.1	+	19	11664	c.11553A>G	c.(11551-11553)GTA>GTG	p.V3851V	ALMS1_uc002sjf.1_Silent_p.V3807V|ALMS1_uc002sjh.1_Silent_p.V3237V	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3849					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TTTTCTAGGTAGCAAACCATG	0.368													36	180					0	0	0	0	G	73826530	G	G	73826530	2	3	69	1	0	0	0	0	0	0	0	1	535	407	15	5		5	ALMS1	2	73826530	Silent	SNP	A	TCGA-CN-6010-01A-11D-1683-08	44586483	73826530	169372843	26	13992											
DPP10	57628	broad.mit.edu	37	chr2	116510785	116510785	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatggttaaatgggtaagcaAtaccaagactgtggtaagat	15	11	11	4	0	0	2	0	0	0	2	0	2	0	2	1	3	2	4	1	3	8	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:116510785A>T	uc002tla.1	+	11	1443	c.986A>T	c.(985-987)AAT>ATT	p.N329I	DPP10_uc002tlb.1_Missense_Mutation_p.N279I|DPP10_uc002tlc.1_Missense_Mutation_p.N325I|DPP10_uc002tle.2_Missense_Mutation_p.N333I|DPP10_uc002tlf.1_Missense_Mutation_p.N322I	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	329	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TGGGTAAGCAATACCAAGACT	0.363													10	41					0	0	0	0	T	116510785	T	T	116510785	3	4	69	1	0	0	0	0	1	0	0	0	4749	101	4	5	1199	5	DPP10	2	116510785	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08	42684255	116510785	126688588	27	13993											
XIRP2	129446	broad.mit.edu	37	chr2	168107879	168107879	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaatggctgaaaatttcgTgaatgaccctgaaaatgaaa	17	10	8	6	1	1	5	1	5	0	0	2	5	1	5	1	1	0	1	1	1	7	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:168107879T>A	uc002udx.2	+	8	9995	c.9977T>A	c.(9976-9978)GTG>GAG	p.V3326E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.V3151E|XIRP2_uc010fpq.2_Missense_Mutation_p.V3104E|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3151					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GAAAATTTCGTGAATGACCCT	0.443													7	78					0	0	0	0	A	168107879	A	A	168107879	3	1	69	1	0	0	0	0	1	0	0	0	17498	1696	59	5	10007	5	XIRP2	2	168107879	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	51597094	168107879	75091494	28	13994											
FASTKD2	22868	broad.mit.edu	37	chr2	207651558	207651558	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcattttgcttgatgaattActttcccctggctcctttta	6	20	5	10	0	1	2	1	2	0	0	3	2	3	2	3	1	2	2	3	1	3	8			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:207651558A>T	uc002vbu.2	+	8	1939	c.1529A>T	c.(1528-1530)TAC>TTC	p.Y510F	FASTKD2_uc002vbv.2_Missense_Mutation_p.Y510F|FASTKD2_uc002vbx.2_Missense_Mutation_p.Y510F|FASTKD2_uc002vbw.1_Missense_Mutation_p.Y510F	NM_001136193	NP_001129665	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	510					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|skin(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		TTGATGAATTACTTTCCCCTG	0.403													35	80					0	0	0	0	T	207651558	T	T	207651558	3	4	69	1	0	0	0	0	1	0	0	0	5718	391	14	5	1555	5	FASTKD2	2	207651558	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08	39543679	207651558	35547815	29	13995											
PIKFYVE	200576	broad.mit.edu	37	chr2	209200049	209200049	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttattctcccattcggcttCttgaagtatgtgttccactc	6	17	7	11	1	2	1	0	1	2	0	6	1	3	1	2	1	0	4	2	1	3	7			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:209200049C>T	uc002vcz.2	+	25	4320	c.4162C>T	c.(4162-4164)CTT>TTT	p.L1388F	PIKFYVE_uc002vcy.1_Missense_Mutation_p.L1332F	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1388					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						CATTCGGCTTCTTGAAGTATG	0.363													71	134					0	0	0	0	T	209200049	T	T	209200049	3	4	69	1	0	0	0	0	1	0	0	0	11979	913	32	2	4267	2	PIKFYVE	2	209200049	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	1548491	209200049	33999324	30	13996											
CPS1	1373	broad.mit.edu	37	chr2	211539654	211539654	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggccaagattccttggtgTggctgaacaattacacaatg	11	10	10	10	1	0	2	0	1	0	1	1	2	1	2	3	3	2	1	3	3	5	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:211539654T>A	uc002vee.3	+	35	4262	c.4130T>A	c.(4129-4131)GTG>GAG	p.V1377E	CPS1_uc010fur.2_Missense_Mutation_p.V1383E|CPS1_uc010fus.2_Missense_Mutation_p.V926E	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1377					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTCCTTGGTGTGGCTGAACAA	0.343													18	121					0	0	0	0	A	211539654	A	A	211539654	3	1	69	1	0	0	0	0	1	0	0	0	3838	1696	59	5	4290	5	CPS1	2	211539654	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	2339605	211539654	31659719	31	13997											
COL4A4	1286	broad.mit.edu	37	chr2	227920692	227920692	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggaccaggtagcccatcAtctccaaagggacctgggat	11	6	13	11	0	2	0	1	0	1	0	3	4	2	4	4	5	1	1	4	5	2	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:227920692A>G	uc010zlt.1	-	30	3339	c.2685T>C	c.(2683-2685)GAT>GAC	p.D895D		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	895	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GTAGCCCATCATCTCCAAAGG	0.582													5	18					0	0	0	0	G	227920692	G	G	227920692	2	3	69	1	0	0	0	0	0	0	0	1	3708	214	8	5		5	COL4A4	2	227920692	Silent	SNP	A	TCGA-CN-6010-01A-11D-1683-08	16381038	227920692	15278681	32	13998											
DGKD	8527	broad.mit.edu	37	chr2	234296984	234296984	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatactttaagcttcgagggCgaacgctttactatgccaaa	12	11	9	9	3	0	0	0	0	0	0	1	3	0	0	1	1	5	2	1	1	6	7			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:234296984C>T	uc002vui.1	+	2	250	c.238C>T	c.(238-240)CGA>TGA	p.R80*	DGKD_uc002vuj.1_Nonsense_Mutation_p.R36*	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	80	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity	p.R80Q(1)		central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GCTTCGAGGGCGAACGCTTTA	0.507													25	59					0	0	0	0	T	234296984	T	T	234296984	4	4	69	1	0	0	0	0	0	1	0	0	4489	760	27	1	268	1	DGKD	2	234296984	Nonsense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	6376292	234296984	8902389	33	13999											
HDAC4	9759	broad.mit.edu	37	chr2	240061464	240061464	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgttgggtgagctgggtccGgagcctggggcgctgctgca	3	10	19	9	2	0	1	0	1	0	0	1	2	1	2	2	5	4	5	2	5	0	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr2:240061464G>A	uc002vyk.3	-	9	1686	c.894C>T	c.(892-894)TCC>TCT	p.S298S	HDAC4_uc010fyz.1_Silent_p.S293S|HDAC4_uc010zoa.1_Silent_p.S293S|HDAC4_uc010fza.2_Silent_p.S298S|HDAC4_uc010fyy.2_Silent_p.S250S|HDAC4_uc010znz.1_Silent_p.S181S|HDAC4_uc010fzb.1_RNA	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	298	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		AGCTGGGTCCGGAGCCTGGGG	0.677													16	28					0	0	0	0	A	240061464	A	A	240061464	2	1	69	1	0	0	0	0	0	0	0	1	7048	1103	39	1		1	HDAC4	2	240061464	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	5764480	240061464	3137909	34	14000											
IQSEC1	9922	broad.mit.edu	37	chr3	12977740	12977740	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggtgtcccgggcccgcgccGcatccagggccggtgcctcc	2	5	15	19	6	0	0	0	0	0	0	3	0	3	0	7	4	1	1	7	4	0	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:12977740G>A	uc003bxt.2	-	3	827	c.818C>T	c.(817-819)GCG>GTG	p.A273V	IQSEC1_uc003bxu.3_Missense_Mutation_p.A151V|IQSEC1_uc011auw.1_Missense_Mutation_p.A259V	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	273					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						GGCCCGCGCCGCATCCAGGGC	0.642													8	24					0	0	0	0	A	12977740	A	A	12977740	3	1	69	1	0	0	0	0	1	0	0	0	7856	1087	38	1	2666	1	IQSEC1	3	12977740	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08		12977740	185044690	35	14001											
KCNH8	131096	broad.mit.edu	37	chr3	19498349	19498349	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctttaacctactgtgatCtccagtgtatcatcctcaaa	11	13	6	11	0	3	1	2	1	1	0	5	1	4	1	3	1	2	2	3	1	4	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:19498349C>A	uc003cbk.1	+	11	2110	c.1915C>A	c.(1915-1917)CTC>ATC	p.L639I	KCNH8_uc010hex.1_Missense_Mutation_p.L100I	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	639	cNMP.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						CTACTGTGATCTCCAGTGTAT	0.403													21	50					5.26018e-13	1.63192e-11	1	0	A	19498349	A	A	19498349	3	1	69	1	0	0	0	0	1	0	0	0	8077	913	32	2	1957	2	KCNH8	3	19498349	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	6520609	19498349	178524081	36	14002											
XIRP1	165904	broad.mit.edu	37	chr3	39227609	39227609	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgctgggatccggggatCacttccacccccaggcctta	6	8	12	15	1	1	0	1	0	0	0	3	2	3	2	5	5	1	2	5	5	1	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:39227609C>A	uc003cjk.1	-	2	3549	c.3328G>T	c.(3328-3330)GAT>TAT	p.D1110Y	XIRP1_uc003cji.2_Missense_Mutation_p.D1110Y|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1110							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		ATCCGGGGATCACTTCCACCC	0.607													12	28					6.40141e-05	0.00170815	1	0	A	39227609	A	A	39227609	3	1	69	1	0	0	0	0	1	0	0	0	17497	826	29	2	2207	2	XIRP1	3	39227609	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	19729260	39227609	158794821	37	14003											
ZNF660	285349	broad.mit.edu	37	chr3	44636533	44636533	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatgaatgtgggaaaacctTcaggcagacttctcaagtta	14	11	9	7	0	2	2	2	1	1	1	3	3	2	3	1	2	1	2	1	2	6	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:44636533T>A	uc003cnl.1	+	3	1181	c.848T>A	c.(847-849)TTC>TAC	p.F283Y		NM_173658	NP_775929	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	283	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		GGGAAAACCTTCAGGCAGACT	0.413													11	25					0	0	0	0	A	44636533	A	A	44636533	3	1	69	1	0	0	0	0	1	0	0	0	18137	1783	62	5	850	5	ZNF660	3	44636533	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	5408924	44636533	153385897	38	14004											
CELSR3	1951	broad.mit.edu	37	chr3	48694142	48694142	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgctcaccggtgaagcgcGggcggcagacgcacgtgtag	7	5	16	13	6	1	2	1	1	0	1	1	2	1	2	2	3	2	4	2	3	2	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:48694142G>C	uc003cul.2	-	2	4669	c.4388C>G	c.(4387-4389)CCG>CGG	p.P1463R	CELSR3_uc003cuf.1_Missense_Mutation_p.P1533R	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1463	Extracellular (Potential).|EGF-like 2; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTGAAGCGCGGGCGGCAGAC	0.687													2	1					0	0	0	0	C	48694142	C	C	48694142	3	2	69	1	0	0	0	0	1	0	0	0	3238	1116	39	3	5686	3	CELSR3	3	48694142	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	4057609	48694142	149328288	39	14005											
IP6K1	9807	broad.mit.edu	37	chr3	49775724	49775724	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaccggtgcaggctccggcGggagtgtttgcgccgaggtt	4	9	18	10	5	0	1	0	1	0	0	1	3	1	2	3	5	2	4	3	5	0	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:49775724G>C	uc003cxm.1	-	3	670	c.355C>G	c.(355-357)CGC>GGC	p.R119G	IP6K1_uc003cxn.1_5'UTR|IP6K1_uc011bcv.1_5'UTR|IP6K1_uc003cxo.2_Missense_Mutation_p.R119G	NM_153273	NP_695005	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1 isoform 1	119					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						AGGCTCCGGCGGGAGTGTTTG	0.542													4	39					0	0	0	0	C	49775724	C	C	49775724	3	2	69	1	0	0	0	0	1	0	0	0	7827	1116	39	3	986	3	IP6K1	3	49775724	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	1081582	49775724	148246706	40	14006											
SEMA3F	6405	broad.mit.edu	37	chr3	50212549	50212549	+	Frame_Shift_Del	DEL	T	-	-																															gccacaccatggacccagacTcaggcggtcagaggccgcgg																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:50212549delT	uc003cyj.2	+	6	675	c.477delT	c.(475-477)ACTfs	p.T159fs	SEMA3F_uc003cyk.2_Intron	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	159	Sema.			Missing (in Ref. 2).	axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		GGACCCAGACTCAGGCGGTCA	0.697													---	---	---								-	50212549	-	-	50212549	7	5	69	1	0	1	0	1	0	0	0	0	14094	1538	54	0	495	0	SEMA3F	3	50212549	Frame_Shift_Del	DEL	T	TCGA-CN-6010-01A-11D-1683-08	436825	50212549	147809881	41	14007											
CCDC14	64770	broad.mit.edu	37	chr3	123665745	123665745	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattttttgccttctgtacaTccttcactgtttttgtatct	5	22	4	10	0	3	0	1	0	2	0	4	0	4	0	2	0	2	3	2	0	2	9			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:123665745T>A	uc011bjx.1	-	8	1341	c.1250A>T	c.(1249-1251)GAT>GTT	p.D417V	CCDC14_uc003egv.3_Intron|CCDC14_uc003egx.3_Missense_Mutation_p.D217V|CCDC14_uc010hrt.2_Missense_Mutation_p.D376V|CCDC14_uc003egy.3_Missense_Mutation_p.D217V|CCDC14_uc003egz.2_Missense_Mutation_p.D217V	NM_022757	NP_073594	Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	417						centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		CTTCTGTACATCCTTCACTGT	0.383													29	157					0	0	0	0	A	123665745	A	A	123665745	3	1	69	1	0	0	0	0	1	0	0	0	2785	1435	50	5	1635	5	CCDC14	3	123665745	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	73453196	123665745	74356685	42	14008											
CLSTN2	64084	broad.mit.edu	37	chr3	140251222	140251222	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggagtttcctgtggtaacCttatacatggatggagcaac	10	12	12	7	0	0	0	0	0	0	0	1	3	1	3	2	4	4	3	2	4	4	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:140251222C>A	uc003etn.2	+	9	1591	c.1401C>A	c.(1399-1401)ACC>ACA	p.T467T	CLSTN2_uc003etm.2_Silent_p.T467T	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	467	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CTGTGGTAACCTTATACATGG	0.413										HNSCC(16;0.037)			17	124					5.35267e-07	1.54866e-05	1	0	A	140251222	A	A	140251222	2	1	69	1	0	0	0	0	0	0	0	1	3577	668	24	4		4	CLSTN2	3	140251222	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	16585477	140251222	57771208	43	14009											
TNIK	23043	broad.mit.edu	37	chr3	170858204	170858204	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacctgttcatgctccgcaCgcctcctctcctcctcccgg	3	11	7	20	3	2	0	1	0	1	0	7	0	6	0	7	1	2	4	7	1	1	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:170858204C>A	uc003fhh.2	-	13	1661	c.1316G>T	c.(1315-1317)CGT>CTT	p.R439L	TNIK_uc003fhi.2_Missense_Mutation_p.R439L|TNIK_uc003fhj.2_Missense_Mutation_p.R439L|TNIK_uc003fhk.2_Missense_Mutation_p.R439L|TNIK_uc003fhl.2_Missense_Mutation_p.R439L|TNIK_uc003fhm.2_Missense_Mutation_p.R439L|TNIK_uc003fhn.2_Missense_Mutation_p.R439L|TNIK_uc003fho.2_Missense_Mutation_p.R439L	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	439	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			ATGCTCCGCACGCCTCCTCTC	0.652													30	112					6.05902e-23	1.92617e-21	1	0	A	170858204	A	A	170858204	3	1	69	1	0	0	0	0	1	0	0	0	16379	536	19	3	2850	3	TNIK	3	170858204	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	30606982	170858204	27164226	44	14010											
PIK3CA	5290	broad.mit.edu	37	chr3	178948153	178948153	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagaatgcacaaagacaagAgaatttgagaggtgagctcg	17	6	12	6	1	0	5	0	2	0	4	1	7	0	5	0	1	2	2	0	1	5	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:178948153A>T	uc003fjk.2	+	20	3082	c.2925A>T	c.(2923-2925)AGA>AGT	p.R975S		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	975	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CAAAGACAAGAGAATTTGAGA	0.323		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			12	245					0	0	0	0	T	178948153	T	T	178948153	3	4	69	1	0	0	0	0	1	0	0	0	11968	301	11	5	2999	5	PIK3CA	3	178948153	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08	8089949	178948153	19074277	45	14011											
TTC14	151613	broad.mit.edu	37	chr3	180321093	180321093	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtggtatcatgagagatatAgcccacttagaaatcacagt	15	10	9	7	0	2	3	2	1	0	2	2	4	2	3	1	1	1	1	1	1	5	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:180321093A>T	uc003fkk.2	+	3	600	c.468A>T	c.(466-468)ATA>ATT	p.I156I	TTC14_uc003fkl.2_Silent_p.I156I|TTC14_uc003fkm.2_Silent_p.I156I	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	156	S1 motif.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TGAGAGATATAGCCCACTTAG	0.358													16	170					0	0	0	0	T	180321093	T	T	180321093	2	4	69	1	0	0	0	0	0	0	0	1	16749	410	15	5		5	TTC14	3	180321093	Silent	SNP	A	TCGA-CN-6010-01A-11D-1683-08	1372940	180321093	17701337	46	14012											
MASP1	5648	broad.mit.edu	37	chr3	186968049	186968050	+	Missense_Mutation	DNP	GG	TT	TT																															gctttcttacttttacaggtGggaatcttgttactccacgt																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:186968049_186968050GG>TT	uc003frh.1	-	8	1411_1412	c.1079_1080CC>AA	c.(1078-1080)CCC>CAA	p.P360Q	MASP1_uc003fri.2_Missense_Mutation_p.P360Q|MASP1_uc003frj.2_Missense_Mutation_p.P329Q|MASP1_uc003frk.1_Missense_Mutation_p.P360Q|MASP1_uc011bse.1_Missense_Mutation_p.P334Q	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	360	Sushi 1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TTTTACAGGTGGGAATCTTGTT	0.287													11	260					0	0	0	0	TT	186968050	TT	TT	186968049	3	4	69	1	0	0	0	0	1	0	0	0	9375	1335	47	4	2000	4	MASP1	3	186968049	Missense_Mutation	DNP	GG	TCGA-CN-6010-01A-11D-1683-08	6646956	186968049	11054381	47	14013											
ATP13A4	84239	broad.mit.edu	37	chr3	193166098	193166098	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcagcagccccagaaatatCaggtctgattctaccgtctc	11	10	7	13	1	5	2	2	1	3	1	6	2	5	2	3	1	3	1	3	1	3	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:193166098C>G	uc003ftd.2	-	18	2157	c.2049G>C	c.(2047-2049)CTG>CTC	p.L683L	ATP13A4_uc003fte.1_Silent_p.L683L|ATP13A4_uc011bsr.1_Silent_p.L154L|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	683	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CCAGAAATATCAGGTCTGATT	0.348													33	97					0	0	0	0	G	193166098	G	G	193166098	2	3	69	1	0	0	0	0	0	0	0	1	1128	813	29	2		2	ATP13A4	3	193166098	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	6198049	193166098	4856332	48	14014											
C3orf43	255798	broad.mit.edu	37	chr3	196235135	196235135	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tggcagcttctcaagcacacGagtatgcaagcagataagta	14	8	10	9	1	1	1	1	0	1	1	2	2	1	1	0	1	4	7	0	1	5	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr3:196235135G>C	uc003fws.2	-	3	425	c.268C>G	c.(268-270)CGT>GGT	p.R90G	C3orf43_uc003fwr.2_Missense_Mutation_p.R82G	NM_001077657	NP_001071125	Q147U7	CC043_HUMAN	hypothetical protein LOC255798	90						integral to membrane				ovary(1)	1	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;2.13e-23)|all cancers(36;2e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00298)		TCAAGCACACGAGTATGCAAG	0.423													6	200					0	0	0	0	C	196235135	C	C	196235135	3	2	69	1	0	0	0	0	1	0	0	0	2240	1058	37	3	380	3	C3orf43	3	196235135	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	3069037	196235135	1787295	49	14015											
LDB2	9079	broad.mit.edu	37	chr4	16760797	16760797	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttactgtatcgctttggtccAtcttccaaacaaaatgaaag	13	13	6	9	1	1	1	0	1	1	0	4	1	3	1	2	1	2	2	2	1	6	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:16760797A>G	uc003goz.2	-	2	535	c.219T>C	c.(217-219)GAT>GAC	p.D73D	LDB2_uc003gpa.2_Silent_p.D73D|LDB2_uc003gpb.2_Silent_p.D73D|LDB2_uc011bxh.1_Silent_p.D73D|LDB2_uc010iee.2_Silent_p.D73D	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	73							LIM domain binding|transcription cofactor activity				0						GCTTTGGTCCATCTTCCAAAC	0.418													11	52					0	0	0	0	G	16760797	G	G	16760797	2	3	69	1	0	0	0	0	0	0	0	1	8736	214	8	5		5	LDB2	4	16760797	Silent	SNP	A	TCGA-CN-6010-01A-11D-1683-08		16760797	174393479	50	14016											
INTS12	57117	broad.mit.edu	37	chr4	106621142	106621142	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaaatgggatcaagttcCaagttcacagtagcagccat	17	8	8	8	0	2	0	2	0	0	0	3	1	3	1	2	1	2	4	2	1	6	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:106621142C>A	uc003hxw.2	-	3	279	c.21G>T	c.(19-21)TTG>TTT	p.L7F	INTS12_uc010ilr.2_Missense_Mutation_p.L7F	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	7					snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		GATCAAGTTCCAAGTTCACAG	0.358													10	168					0.000151284	0.00391515	1	0	A	106621142	A	A	106621142	3	1	69	1	0	0	0	0	1	0	0	0	7816	593	21	4	1391	4	INTS12	4	106621142	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	89860345	106621142	84533134	51	14017											
PCDH10	57575	broad.mit.edu	37	chr4	134072296	134072296	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgtgcaagccaaggacctggGccccaacgccgtgcctgcgc	7	4	13	17	4	0	0	0	0	0	0	0	1	0	1	6	2	5	1	6	2	3	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:134072296G>T	uc003iha.2	+	1	1827	c.1001G>T	c.(1000-1002)GGC>GTC	p.G334V	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.G334V	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	334	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		AAGGACCTGGGCCCCAACGCC	0.597													11	40					3.86212e-05	0.00104684	1	0	T	134072296	T	T	134072296	3	4	69	1	0	0	0	0	1	0	0	0	11561	1203	42	4	1003	4	PCDH10	4	134072296	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	27451154	134072296	57081980	52	14018											
MTNR1A	4543	broad.mit.edu	37	chr4	187455231	187455231	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtttgggtttgcggtcaggtTtcaccctctgtctgacctgg	3	15	13	10	1	4	1	2	1	2	0	4	1	4	1	2	4	1	3	2	4	0	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr4:187455231T>A	uc003izd.1	-	2	683	c.665A>T	c.(664-666)AAA>ATA	p.K222I		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	222	Cytoplasmic (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	GCGGTCAGGTTTCACCCTCTG	0.478													14	78					0	0	0	0	A	187455231	A	A	187455231	3	1	69	1	0	0	0	0	1	0	0	0	10004	1841	64	5	391	5	MTNR1A	4	187455231	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	53382935	187455231	3699045	53	14019											
SPEF2	79925	broad.mit.edu	37	chr5	35641632	35641632	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcccatggcatcatcacAgaaaagcctggggtggcaac	11	6	13	11	0	2	1	2	0	0	1	2	1	2	1	2	5	2	2	2	5	3	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:35641632A>C	uc003jjo.2	+	3	372	c.261A>C	c.(259-261)ACA>ACC	p.T87T	SPEF2_uc003jjn.1_Silent_p.T87T|SPEF2_uc003jjq.3_Silent_p.T87T	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	87	CH.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCATCATCACAGAAAAGCCTG	0.438													10	83					0	0	0	0	C	35641632	C	C	35641632	2	2	69	1	0	0	0	0	0	0	0	1	15101	175	7	5		5	SPEF2	5	35641632	Silent	SNP	A	TCGA-CN-6010-01A-11D-1683-08		35641632	145273628	54	14020											
LMBRD2	92255	broad.mit.edu	37	chr5	36141228	36141228	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgttaaaaattgtgacgTccaatacactaccctccaga	14	10	5	12	1	0	2	0	1	0	1	2	2	2	2	4	0	2	1	4	0	6	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:36141228T>C	uc003jkb.1	-	4	764	c.349A>G	c.(349-351)ACG>GCG	p.T117A		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	117	Helical; (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AATTGTGACGTCCAATACACT	0.313													30	103					0	0	0	0	C	36141228	C	C	36141228	3	2	69	1	0	0	0	0	1	0	0	0	8885	1667	58	5	1798	5	LMBRD2	5	36141228	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	499596	36141228	144774032	55	14021											
HEATR7B2	133558	broad.mit.edu	37	chr5	40999824	40999824	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcacctcccaggtgctggTgaagaaggtgaaggagtgtg	10	8	16	7	0	1	3	1	2	0	1	2	5	2	4	2	4	1	1	2	4	3	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:40999824T>G	uc003jmj.3	-	40	5030	c.4540A>C	c.(4540-4542)ACC>CCC	p.T1514P	HEATR7B2_uc003jmi.3_Missense_Mutation_p.T1069P	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1514							binding			ovary(6)|central_nervous_system(2)	8						CAGGTGCTGGTGAAGAAGGTG	0.468													3	63					0	0	0	0	G	40999824	G	G	40999824	3	3	69	1	0	0	0	0	1	0	0	0	7074	1696	59	5	229	5	HEATR7B2	5	40999824	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	4858596	40999824	139915436	56	14022											
RNF180	285671	broad.mit.edu	37	chr5	63509383	63509383	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tattcttctttattacctgtAggcccagtggacagttggaa	9	15	9	8	0	2	0	0	0	2	0	2	2	2	2	2	3	1	2	2	3	5	8			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:63509383A>T	uc003jti.2	+	4	342	c.232_splice	c.e4-2	p.A78_splice	RNF180_uc003jth.3_Splice_Site_p.A78_splice|RNF180_uc010iws.2_Intron	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1							integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		TATTACCTGTAGGCCCAGTGG	0.398													28	107					0	0	0	0	T	63509383	T	T	63509383	5	4	69	1	0	0	0	0	0	0	1	0	13529	434	15	5	240	5	RNF180	5	63509383	Splice_Site	SNP	A	TCGA-CN-6010-01A-11D-1683-08	22509559	63509383	117405877	57	14023											
GPR98	84059	broad.mit.edu	37	chr5	90004696	90004696	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttacgttggacttaccatgGctgcttcaacttcatttcct	7	16	6	12	1	2	0	2	0	0	0	3	1	3	1	2	2	4	3	2	2	3	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:90004696G>T	uc003kju.2	+	39	8890	c.8794G>T	c.(8794-8796)GCT>TCT	p.A2932S	GPR98_uc003kjt.2_Missense_Mutation_p.A638S|GPR98_uc003kjv.2_Missense_Mutation_p.A532S	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2932	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACTTACCATGGCTGCTTCAAC	0.343													32	52					6.05902e-23	1.92617e-21	1	0	T	90004696	T	T	90004696	3	4	69	1	0	0	0	0	1	0	0	0	6760	1203	42	4	8948	4	GPR98	5	90004696	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	26495313	90004696	90910564	58	14024											
SLC22A5	6584	broad.mit.edu	37	chr5	131714117	131714117	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggccccactcacaatctcCttgttcttcgtgggtgtgct	6	13	9	13	1	3	0	1	0	2	0	5	0	3	0	3	2	1	2	3	2	2	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:131714117C>T	uc003kww.3	+	2	705	c.441C>T	c.(439-441)TCC>TCT	p.S147S	SLC22A5_uc003kwx.3_Silent_p.S171S	NM_003060	NP_003051	O76082	S22A5_HUMAN	solute carrier family 22 member 5	147	Helical; Name=2; (Potential).				positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity				0		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	TCACAATCTCCTTGTTCTTCG	0.507													18	117					0	0	0	0	T	131714117	T	T	131714117	2	4	69	1	0	0	0	0	0	0	0	1	14521	668	24	4		4	SLC22A5	5	131714117	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	41709421	131714117	49201143	59	14025											
CXXC5	51523	broad.mit.edu	37	chr5	139060331	139060331	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcaacaagagcctgcgcCgctcccgcccgctctcccac	6	5	7	23	4	2	1	1	0	1	1	4	1	3	1	6	0	3	2	6	0	2	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:139060331C>T	uc010jfg.1	+	2	513	c.223C>T	c.(223-225)CGC>TGC	p.R75C	CXXC5_uc003let.2_Missense_Mutation_p.R75C	NM_016463	NP_057547	Q7LFL8	CXXC5_HUMAN	CXXC finger 5	75					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCCTGCGCCGCTCCCGCCC	0.647													7	24					0	0	0	0	T	139060331	T	T	139060331	3	4	69	1	0	0	0	0	1	0	0	0	4116	652	23	1	225	1	CXXC5	5	139060331	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	7346214	139060331	41854929	60	14026											
PCDHA5	56143	broad.mit.edu	37	chr5	140202711	140202711	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggccgacgtgaacgacaacGctccggcgttcgcgcagccc	7	5	13	16	8	0	1	0	1	0	0	2	3	1	1	3	2	3	3	3	2	2	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140202711G>A	uc003lhl.2	+	1	1351	c.1351G>A	c.(1351-1353)GCT>ACT	p.A451T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.A451T|PCDHA5_uc003lhj.1_Missense_Mutation_p.A451T	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	451	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACGACAACGCTCCGGCGTT	0.667													11	23					0	0	0	0	A	140202711	A	A	140202711	3	1	69	1	0	0	0	0	1	0	0	0	11581	1087	38	1	1353	1	PCDHA5	5	140202711	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	1142380	140202711	40712549	61	14027											
PCDHA7	56141	broad.mit.edu	37	chr5	140216085	140216085	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgatcatcgccatctgcgCggtgtccagtctgttggtgc	4	12	12	13	3	3	1	1	1	2	0	5	1	4	1	3	2	2	1	3	2	0	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140216085C>T	uc003lhq.2	+	1	2117	c.2117C>T	c.(2116-2118)GCG>GTG	p.A706V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.A706V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	706	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCATCTGCGCGGTGTCCAGT	0.617													7	19					0	0	0	0	T	140216085	T	T	140216085	3	4	69	1	0	0	0	0	1	0	0	0	11583	768	27	1	2119	1	PCDHA7	5	140216085	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	13374	140216085	40699175	62	14028											
PCDHA7	56141	broad.mit.edu	37	chr5	140216146	140216146	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgttgcggtgctcagcgccGtcctctgagggcgcatgtag	4	9	16	12	5	2	1	1	1	1	0	3	1	3	1	2	2	3	4	2	2	1	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140216146G>A	uc003lhq.2	+	1	2178	c.2178G>A	c.(2176-2178)CCG>CCA	p.P726P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.P726P	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	726	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCAGCGCCGTCCTCTGAGG	0.612													11	16					0	0	0	0	A	140216146	A	A	140216146	2	1	69	1	0	0	0	0	0	0	0	1	11583	1132	40	1		1	PCDHA7	5	140216146	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	61	140216146	40699114	63	14029											
PCDHA11	56138	broad.mit.edu	37	chr5	140250594	140250594	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agataagcacaacgcgtgccCtggacgaggcagactcgccg	11	4	13	13	5	0	2	0	0	0	2	1	4	0	3	2	2	3	2	2	2	2	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140250594C>A	uc003lia.2	+	1	2764	c.1906C>A	c.(1906-1908)CTG>ATG	p.L636M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.L636M	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	636	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGCGTGCCCTGGACGAGGC	0.662													6	23					3.59834e-05	0.000980499	1	0	A	140250594	A	A	140250594	3	1	69	1	0	0	0	0	1	0	0	0	11575	680	24	4	1908	4	PCDHA11	5	140250594	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	34448	140250594	40664666	64	14030											
PCDHB11	56125	broad.mit.edu	37	chr5	140579439	140579439	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaggcgggctctgaaacctGgagcttttctgtggcagaag	8	10	14	9	1	3	2	1	1	2	1	3	3	3	3	1	4	2	3	1	4	2	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140579439G>A	uc003liy.2	+	1	92	c.92G>A	c.(91-93)TGG>TAG	p.W31*	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	31	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTGAAACCTGGAGCTTTTCT	0.527													7	29					0	0	0	0	A	140579439	A	A	140579439	4	1	69	1	0	0	0	0	0	1	0	0	11590	1357	47	4	94	4	PCDHB11	5	140579439	Nonsense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	328845	140579439	40335821	65	14031											
PCDHGA4	56111	broad.mit.edu	37	chr5	140735676	140735676	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgagtggggatataacaatAttggggggtctagattatga	12	12	14	3	0	1	3	0	2	1	1	1	4	1	4	0	5	1	0	0	5	6	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140735676A>T	uc003ljq.1	+	1	909	c.909A>T	c.(907-909)ATA>ATT	p.I303I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.I303I	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	303	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATATAACAATATTGGGGGGTC	0.443													5	18					0	0	0	0	T	140735676	T	T	140735676	2	4	69	1	0	0	0	0	0	0	0	1	11610	439	16	5		5	PCDHGA4	5	140735676	Silent	SNP	A	TCGA-CN-6010-01A-11D-1683-08	156237	140735676	40179584	66	14032											
PCDHGB6	56100	broad.mit.edu	37	chr5	140788007	140788007	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgcacttcagcgtagacgcgGagagcggggacttacttgtg	8	9	15	9	4	1	2	1	0	0	2	1	4	1	3	0	3	4	2	0	3	2	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:140788007G>C	uc003lkj.1	+	1	238	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.E80Q	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	80	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTAGACGCGGAGAGCGGGGA	0.537													18	34					0	0	0	0	C	140788007	C	C	140788007	3	2	69	1	0	0	0	0	1	0	0	0	11621	1175	41	2	240	2	PCDHGB6	5	140788007	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	52331	140788007	40127253	67	14033											
STK32A	202374	broad.mit.edu	37	chr5	146752790	146752790	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgatgtccagaacttccCgtatatgaatgatataaact	14	13	6	8	1	1	4	0	3	1	1	3	4	3	4	2	0	2	1	2	0	7	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:146752790C>A	uc010jgn.1	+	10	1116	c.836C>A	c.(835-837)CCG>CAG	p.P279Q	STK32A_uc003lom.2_Missense_Mutation_p.P279Q|STK32A_uc011dbw.1_Missense_Mutation_p.P279Q	NM_001112724	NP_001106195	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A isoform 1	279	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAACTTCCCGTATATGAAT	0.378													7	90					0.000157383	0.00399273	1	0	A	146752790	A	A	146752790	3	1	69	1	0	0	0	0	1	0	0	0	15363	652	23	3	903	3	STK32A	5	146752790	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	5964783	146752790	34162470	68	14034											
LARP1	23367	broad.mit.edu	37	chr5	154179306	154179306	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttgttccccgtcagcactaCcaaaaggagacaggtaggta	12	9	10	10	1	1	1	1	0	0	1	2	2	2	1	3	3	2	4	3	3	5	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:154179306C>T	uc003lvp.2	+	9	1962	c.1533C>T	c.(1531-1533)TAC>TAT	p.Y511Y	LARP1_uc003lvo.2_Silent_p.Y434Y|LARP1_uc010jie.1_Silent_p.Y306Y	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	511							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTCAGCACTACCAAAAGGAGA	0.527													18	26					0	0	0	0	T	154179306	T	T	154179306	2	4	69	1	0	0	0	0	0	0	0	1	8668	518	18	4		4	LARP1	5	154179306	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	7426516	154179306	26735954	69	14035											
KIF4B	285643	broad.mit.edu	37	chr5	154394225	154394225	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tattaaccgaggcctcctatGcttgggaaatgtaatcagtg	11	12	10	8	1	1	0	1	0	0	0	2	2	2	1	3	2	2	2	3	2	5	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:154394225G>A	uc010jih.1	+	1	966	c.806G>A	c.(805-807)TGC>TAC	p.C269Y		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	269	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GGCCTCCTATGCTTGGGAAAT	0.443													15	58					0	0	0	0	A	154394225	A	A	154394225	3	1	69	1	0	0	0	0	1	0	0	0	8343	1319	46	4	808	4	KIF4B	5	154394225	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	214919	154394225	26521035	70	14036											
HAVCR1	26762	broad.mit.edu	37	chr5	156469687	156469687	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagactctgtcacggtgtcaTtcccatctactcaacaagaa	13	10	6	12	1	5	2	3	0	2	2	6	2	6	2	1	1	2	0	1	1	5	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:156469687T>C	uc010jij.1	-	6	973	c.788A>G	c.(787-789)AAT>AGT	p.N263S	HAVCR1_uc011ddl.1_Missense_Mutation_p.N94S|HAVCR1_uc003lwi.2_Missense_Mutation_p.N263S	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	258	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CACGGTGTCATTCCCATCTAC	0.353													16	83					0	0	0	0	C	156469687	C	C	156469687	3	2	69	1	0	0	0	0	1	0	0	0	7012	1493	52	5	322	5	HAVCR1	5	156469687	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	2075462	156469687	24445573	71	14037											
FABP6	2172	broad.mit.edu	37	chr5	159659192	159659192	+	Frame_Shift_Del	DEL	A	-	-																															gcaggacttcacttggtcccAgcactactccgggggccaca																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:159659192delA	uc003lya.1	+	2	283	c.155delA	c.(154-156)CAGfs	p.Q52fs	FABP6_uc003lxx.1_Frame_Shift_Del_p.Q101fs|FABP6_uc003lxz.1_Frame_Shift_Del_p.Q101fs	NM_001445	NP_001436	P51161	FABP6_HUMAN	gastrotropin isoform 2	52					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTTGGTCCCAGCACTACTCC	0.567													---	---	---								-	159659192	-	-	159659192	7	5	69	1	0	1	0	1	0	0	0	0	5389	188	7	0	316	0	FABP6	5	159659192	Frame_Shift_Del	DEL	A	TCGA-CN-6010-01A-11D-1683-08	3189505	159659192	21256068	72	14038											
UBTD2	92181	broad.mit.edu	37	chr5	171639129	171639129	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcaggaatatccagagtcTctatgtcgctcttttcctct	7	15	7	12	1	4	1	1	0	3	1	8	2	6	2	2	1	0	2	2	1	3	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr5:171639129T>C	uc003mbp.1	-	3	536	c.410A>G	c.(409-411)GAG>GGG	p.E137G		NM_152277	NP_689490	Q8WUN7	UBTD2_HUMAN	dendritic cell-derived ubiquitin-like protein	137						cytoplasm					0	Renal(175;0.000159)|Lung NSC(126;0.00976)|all_lung(126;0.0156)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATCCAGAGTCTCTATGTCGCT	0.488													32	29					0	0	0	0	C	171639129	C	C	171639129	3	2	69	1	0	0	0	0	1	0	0	0	16976	1551	54	5	298	5	UBTD2	5	171639129	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	11979937	171639129	9276131	73	14039											
NKAPL	222698	broad.mit.edu	37	chr6	28227756	28227756	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaagcataggaaatattctGatagtgacagtaactcagag	17	9	10	5	0	2	3	1	2	1	1	2	5	2	4	0	1	2	2	0	1	6	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:28227756G>C	uc003nkt.2	+	1	659	c.607G>C	c.(607-609)GAT>CAT	p.D203H	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	203	Lys-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						GAAATATTCTGATAGTGACAG	0.294													19	51					0	0	0	0	C	28227756	C	C	28227756	3	2	69	1	0	0	0	0	1	0	0	0	10494	1290	45	2	609	2	NKAPL	6	28227756	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08		28227756	142887311	74	14040											
C6orf204	387119	broad.mit.edu	37	chr6	118790380	118790380	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcaaatcaaatagtggccgTttggaaagaactgtctgctg	12	11	11	7	1	3	1	2	0	1	1	3	2	3	2	1	2	2	2	1	2	5	2	rs77465615		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:118790380T>C	uc003pxz.1	-	12	2697	c.2109A>G	c.(2107-2109)AAA>AAG	p.K703K		NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	703						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		ATAGTGGCCGTTTGGAAAGAA	0.418													30	99					0	0	0	0	C	118790380	C	C	118790380	2	2	69	1	0	0	0	0	0	0	0	1	2363	1722	60	5		5	C6orf204	6	118790380	Silent	SNP	T	TCGA-CN-6010-01A-11D-1683-08	90562624	118790380	52324687	75	14041											
STXBP5	134957	broad.mit.edu	37	chr6	147694921	147694921	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacctgaagcaccaaacaggGgattctttaaaggcttattt	13	11	8	9	0	1	1	0	1	1	0	1	2	1	2	2	3	2	2	2	3	5	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:147694921G>A	uc003qlz.2	+	26	3297	c.3136G>A	c.(3136-3138)GGA>AGA	p.G1046R	STXBP5_uc010khz.1_Missense_Mutation_p.G1010R|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.G701R	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	1046					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		ACCAAACAGGGGATTCTTTAA	0.348													6	65					0	0	0	0	A	147694921	A	A	147694921	3	1	69	1	0	0	0	0	1	0	0	0	15422	1233	43	4	3238	4	STXBP5	6	147694921	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	28904541	147694921	23420146	76	14042											
TFB1M	51106	broad.mit.edu	37	chr6	155632378	155632378	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccagaagttcagcgacgtCggcattaagaatagatcttg	13	9	10	9	3	2	3	1	0	1	3	3	4	2	3	1	1	1	2	1	1	4	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr6:155632378C>A	uc003qqj.3	-	2	293	c.229G>T	c.(229-231)GAC>TAC	p.D77Y	TFB1M_uc003qqk.2_Intron	NM_016020	NP_057104	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			skin(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		TCAGCGACGTCGGCATTAAGA	0.438													22	61					1.96895e-08	6.00005e-07	1	0	A	155632378	A	A	155632378	3	1	69	1	0	0	0	0	1	0	0	0	15859	884	31	3	835	3	TFB1M	6	155632378	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	7937457	155632378	15482689	77	14043											
RBAK	57786	broad.mit.edu	37	chr7	5103754	5103754	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaggctgtttttattgctCataagagagcttacataggg	11	14	11	5	0	1	2	1	1	0	1	1	3	1	2	0	2	3	4	0	2	4	7			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:5103754C>G	uc010kss.1	+	6	991	c.667C>G	c.(667-669)CAT>GAT	p.H223D	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.H223D	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	223	Required for interaction with RB1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TTTTATTGCTCATAAGAGAGC	0.348													12	45					0	0	0	0	G	5103754	G	G	5103754	3	3	69	1	0	0	0	0	1	0	0	0	13165	826	29	2	681	2	RBAK	7	5103754	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08		5103754	154034909	78	14044											
HDAC9	9734	broad.mit.edu	37	chr7	18687544	18687544	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tactttagagggaaagccacCcaacagcagccaccaggctc	13	5	9	14	0	0	1	0	0	0	1	1	2	0	2	4	2	5	2	4	2	4	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:18687544C>T	uc003suh.2	+	9	1204	c.1163C>T	c.(1162-1164)CCC>CTC	p.P388L	HDAC9_uc003sue.2_Missense_Mutation_p.P388L|HDAC9_uc011jyd.1_Missense_Mutation_p.P388L|HDAC9_uc003sui.2_Missense_Mutation_p.P391L|HDAC9_uc003suj.2_Missense_Mutation_p.P347L|HDAC9_uc011jya.1_Missense_Mutation_p.P385L|HDAC9_uc003sua.1_Missense_Mutation_p.P366L|HDAC9_uc011jyb.1_Missense_Mutation_p.P344L|HDAC9_uc003sud.1_Missense_Mutation_p.P388L|HDAC9_uc011jyc.1_Missense_Mutation_p.P347L|HDAC9_uc003suf.1_Missense_Mutation_p.P419L|HDAC9_uc010kud.1_Missense_Mutation_p.P391L|HDAC9_uc011jye.1_Missense_Mutation_p.P360L|HDAC9_uc011jyf.1_Missense_Mutation_p.P311L|HDAC9_uc010kue.1_Missense_Mutation_p.P131L	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	388					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	GGAAAGCCACCCAACAGCAGC	0.502													4	8					0	0	0	0	T	18687544	T	T	18687544	3	4	69	1	0	0	0	0	1	0	0	0	7053	623	22	4	1206	4	HDAC9	7	18687544	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	13583790	18687544	140451119	79	14045											
NUPL2	11097	broad.mit.edu	37	chr7	23240136	23240136	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggctggttttggtagtccGggctcacattctcacactgc	5	13	12	11	1	2	0	2	0	1	0	4	0	3	0	1	4	1	4	1	4	1	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:23240136G>C	uc003svu.2	+	7	1303	c.1044G>C	c.(1042-1044)CCG>CCC	p.P348P	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_Silent_p.P225P|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_Silent_p.P225P|NUPL2_uc011jyx.1_Silent_p.P120P	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	348	Ser-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						TTGGTAGTCCGGGCTCACATT	0.507													4	95					0	0	0	0	C	23240136	C	C	23240136	2	2	69	1	0	0	0	0	0	0	0	1	10829	1103	39	3		3	NUPL2	7	23240136	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	4552592	23240136	135898527	80	14046											
SCRN1	9805	broad.mit.edu	37	chr7	29983623	29983623	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggcagcccagtacttccCtatggtctcgagcacccagg	7	8	10	16	2	1	0	0	0	1	0	4	1	2	0	3	3	3	3	3	3	2	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:29983623C>G	uc010kvp.2	-	3	718	c.514G>C	c.(514-516)GGG>CGG	p.G172R	SCRN1_uc011jzy.1_Missense_Mutation_p.G104R|SCRN1_uc003tak.2_Missense_Mutation_p.G172R|SCRN1_uc011jzz.1_Missense_Mutation_p.G172R|SCRN1_uc011kaa.1_Missense_Mutation_p.G192R|SCRN1_uc011jzw.1_Missense_Mutation_p.G104R|SCRN1_uc011jzx.1_Intron	NM_001145515	NP_001138987	Q12765	SCRN1_HUMAN	secernin 1 isoform c	172					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			ovary(2)	2						CAGTACTTCCCTATGGTCTCG	0.527													7	45					0	0	0	0	G	29983623	G	G	29983623	3	3	69	1	0	0	0	0	1	0	0	0	14003	681	24	4	750	4	SCRN1	7	29983623	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	6743487	29983623	129155040	81	14047											
YWHAG	7532	broad.mit.edu	37	chr7	75958917	75958917	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attgttgccttcgccgccatCgtcgtcctgctggtcgctcg	2	13	11	15	6	0	0	0	0	0	0	6	0	1	0	4	1	2	3	4	1	0	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:75958917C>T	uc011kgj.1	-	2	938	c.721G>A	c.(721-723)GAT>AAT	p.D241N		NM_012479	NP_036611	P61981	1433G_HUMAN	tyrosine 3-monooxygenase/tryptophan	241					G2/M transition of mitotic cell cycle|regulation of neuron differentiation|regulation of signal transduction|regulation of synaptic plasticity	cytosol	insulin-like growth factor receptor binding|protein kinase C binding|protein kinase C inhibitor activity			ovary(1)|lung(1)	2						TCGCCGCCATCGTCGTCCTGC	0.587													8	8					0	0	0	0	T	75958917	T	T	75958917	3	4	69	1	0	0	0	0	1	0	0	0	17571	884	31	1	26	1	YWHAG	7	75958917	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	45975294	75958917	83179746	82	14048											
SEMA3E	9723	broad.mit.edu	37	chr7	83035320	83035320	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtactgagcaaacgagtctcGcttttaggaaagtgctccac	11	10	10	10	2	1	1	0	1	1	0	3	3	2	2	1	1	4	4	1	1	4	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:83035320G>C	uc003uhy.1	-	8	1335	c.869C>G	c.(868-870)GCG>GGG	p.A290G		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	290	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				AACGAGTCTCGCTTTTAGGAA	0.348													6	154					0	0	0	0	C	83035320	C	C	83035320	3	2	69	1	0	0	0	0	1	0	0	0	14093	1087	38	3	1498	3	SEMA3E	7	83035320	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	7076403	83035320	76103343	83	14049											
ABCB4	5244	broad.mit.edu	37	chr7	87069700	87069700	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tacattaaagttcctaatatCctgcccatcaatgttaatct	13	15	3	10	0	2	0	1	0	1	0	4	0	4	0	3	0	2	2	3	0	7	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:87069700C>A	uc003uiv.1	-	13	1451	c.1375G>T	c.(1375-1377)GAT>TAT	p.D459Y	ABCB4_uc003uiw.1_Missense_Mutation_p.D459Y|ABCB4_uc003uix.1_Missense_Mutation_p.D459Y	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	459	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTCCTAATATCCTGCCCATCA	0.348													9	46					5.68852e-11	1.75425e-09	1	0	A	87069700	A	A	87069700	3	1	69	1	0	0	0	0	1	0	0	0	43	855	30	2	2549	2	ABCB4	7	87069700	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	4034380	87069700	72068963	84	14050											
MUC17	140453	broad.mit.edu	37	chr7	100681270	100681270	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgttgacaccagcacaccTgtgaccaattctactgaagc	11	9	7	14	0	1	3	0	3	1	0	1	3	1	3	4	0	3	2	4	0	3	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:100681270T>C	uc003uxp.1	+	3	6626	c.6573T>C	c.(6571-6573)CCT>CCC	p.P2191P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2191	Extracellular (Potential).|35.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAGCACACCTGTGACCAATT	0.483													21	192					0	0	0	0	C	100681270	C	C	100681270	2	2	69	1	0	0	0	0	0	0	0	1	10027	1567	55	5		5	MUC17	7	100681270	Silent	SNP	T	TCGA-CN-6010-01A-11D-1683-08	13611570	100681270	58457393	85	14051											
LRRC17	10234	broad.mit.edu	37	chr7	102574878	102574878	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgtacttgtgagatagaaaCgcttatttcaatgttgcaga	12	14	9	6	1	1	3	1	1	0	3	1	4	1	3	0	0	3	4	0	0	5	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:102574878C>T	uc003vau.2	+	2	907	c.518C>T	c.(517-519)ACG>ATG	p.T173M	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_Missense_Mutation_p.T173M	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	173	LRRCT 1.				bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						GAGATAGAAACGCTTATTTCA	0.433													12	103					0	0	0	0	T	102574878	T	T	102574878	3	4	69	1	0	0	0	0	1	0	0	0	9023	536	19	1	520	1	LRRC17	7	102574878	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	1893608	102574878	56563785	86	14052											
RELN	5649	broad.mit.edu	37	chr7	103207105	103207105	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttcgcgtcctgtggcaGgtcaatggaaatgatctgtg	7	13	13	8	2	3	1	1	1	2	0	5	2	4	2	1	3	0	1	1	3	2	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:103207105G>C	uc003vca.2	-	32	4850	c.4690C>G	c.(4690-4692)CTG>GTG	p.L1564V	RELN_uc010liz.2_Missense_Mutation_p.L1564V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1564					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCTGTGGCAGGTCAATGGAA	0.473													7	41					0	0	0	0	C	103207105	C	C	103207105	3	2	69	1	0	0	0	0	1	0	0	0	13285	991	35	4	5828	4	RELN	7	103207105	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	632227	103207105	55931558	87	14053											
C7orf58	79974	broad.mit.edu	37	chr7	120629688	120629688	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aactggtcatggtctgtcgcCcagtgttcccttgtcgtcgg	4	13	12	12	3	2	0	1	0	1	0	6	0	3	0	2	3	1	1	2	3	1	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:120629688C>G	uc003vjq.3	+	2	460	c.13C>G	c.(13-15)CCA>GCA	p.P5A	C7orf58_uc003vjr.1_Missense_Mutation_p.P5A|C7orf58_uc003vjs.3_Missense_Mutation_p.P5A	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	5						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					GGTCTGTCGCCCAGTGTTCCC	0.522													10	59					0	0	0	0	G	120629688	G	G	120629688	3	3	69	1	0	0	0	0	1	0	0	0	2416	623	22	4	15	4	C7orf58	7	120629688	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	17422583	120629688	38508975	88	14054											
PTPRZ1	5803	broad.mit.edu	37	chr7	121701229	121701229	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggacagtaatggtgcagcAttgcctgatggaaatatagc	12	10	12	7	0	0	1	0	1	0	0	0	3	0	3	1	3	4	3	1	3	4	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:121701229A>C	uc003vjy.2	+	30	7298	c.6903A>C	c.(6901-6903)GCA>GCC	p.A2301A	PTPRZ1_uc003vjz.2_Silent_p.A1434A|PTPRZ1_uc011knt.1_Silent_p.A891A	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	2301	Cytoplasmic (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ATGGTGCAGCATTGCCTGATG	0.448													24	38					0	0	0	0	C	121701229	C	C	121701229	2	2	69	1	0	0	0	0	0	0	0	1	12879	204	8	5		5	PTPRZ1	7	121701229	Silent	SNP	A	TCGA-CN-6010-01A-11D-1683-08	1071541	121701229	37437434	89	14055											
IQUB	154865	broad.mit.edu	37	chr7	123097503	123097503	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagaagaatgcagttccaggGggaccactccagggatttat	13	8	12	8	0	0	2	0	0	0	2	2	4	2	4	3	3	1	2	3	3	4	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:123097503G>A	uc003vkn.2	-	12	2702	c.2125C>T	c.(2125-2127)CCC>TCC	p.P709S	IQUB_uc011kny.1_Missense_Mutation_p.P42S|IQUB_uc003vko.2_Missense_Mutation_p.P709S|IQUB_uc010lkt.2_RNA	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	709										ovary(3)|large_intestine(1)	4						CAGTTCCAGGGGGACCACTCC	0.453													18	96					0	0	0	0	A	123097503	A	A	123097503	3	1	69	1	0	0	0	0	1	0	0	0	7859	1232	43	4	258	4	IQUB	7	123097503	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	1396274	123097503	36041160	90	14056											
FLNC	2318	broad.mit.edu	37	chr7	128492757	128492757	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagcatccgtgccccctcGggcaacgaggagccctgcct	6	5	12	18	3	0	0	0	0	0	0	2	2	1	1	6	2	5	2	6	2	1	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:128492757G>A	uc003vnz.3	+	36	6164	c.5955G>A	c.(5953-5955)TCG>TCA	p.S1985S	FLNC_uc003voa.3_Silent_p.S1952S	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1985	Filamin 18.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GTGCCCCCTCGGGCAACGAGG	0.657													6	22					0	0	0	0	A	128492757	A	A	128492757	2	1	69	1	0	0	0	0	0	0	0	1	5967	1103	39	1		1	FLNC	7	128492757	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	5395254	128492757	30645906	91	14057											
CNTNAP2	26047	broad.mit.edu	37	chr7	147183067	147183067	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatggtggaaagtgctcgCaaacatgggacagcttcaaa	14	7	12	8	1	1	0	1	0	0	0	2	2	1	2	0	3	4	4	0	3	3	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr7:147183067C>G	uc003weu.1	+	11	2227	c.1711C>G	c.(1711-1713)CAA>GAA	p.Q571E		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	571	EGF-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAAGTGCTCGCAAACATGGGA	0.443										HNSCC(39;0.1)			17	77					0	0	0	0	G	147183067	G	G	147183067	3	3	69	1	0	0	0	0	1	0	0	0	3662	711	25	4	1753	4	CNTNAP2	7	147183067	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	18690310	147183067	11955596	92	14058											
AMAC1L2	83650	broad.mit.edu	37	chr8	11189001	11189001	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaggtggtgcccgctggcaAcgctgccactgttcgcaaag	7	8	13	13	3	1	0	1	0	0	0	2	0	1	0	2	3	3	5	2	3	2	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:11189001A>G	uc003wtp.1	+	1	507	c.386A>G	c.(385-387)AAC>AGC	p.N129S		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	129	DUF6 1.					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		CCCGCTGGCAACGCTGCCACT	0.612													13	57					0	0	0	0	G	11189001	G	G	11189001	3	3	69	1	0	0	0	0	1	0	0	0	560	43	2	5	388	5	AMAC1L2	8	11189001	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08		11189001	135175021	93	14059											
TUSC3	7991	broad.mit.edu	37	chr8	15519695	15519695	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagaccacccaactactctGgtaccattgctttggccctg	8	11	7	15	0	2	1	1	0	1	1	2	1	2	1	4	2	4	2	4	2	3	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:15519695G>T	uc003wwt.2	+	5	808	c.598G>T	c.(598-600)GGT>TGT	p.G200C	TUSC3_uc003wwr.2_Missense_Mutation_p.G200C|TUSC3_uc003wws.2_Missense_Mutation_p.G200C|TUSC3_uc003wwu.2_Missense_Mutation_p.G200C|TUSC3_uc003wwv.2_Missense_Mutation_p.G200C|TUSC3_uc003www.2_Missense_Mutation_p.G200C|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.G200C	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	200	Helical; (Potential).				cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		CAACTACTCTGGTACCATTGC	0.368													8	117					0.000274275	0.00689033	1	0	T	15519695	T	T	15519695	3	4	69	1	0	0	0	0	1	0	0	0	16846	1348	47	4	616	4	TUSC3	8	15519695	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	4330694	15519695	130844327	94	14060											
HMBOX1	79618	broad.mit.edu	37	chr8	28906499	28906499	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcctggagagtcatgggatAgatgtgcagagtccaggagg	11	8	16	6	0	1	3	1	0	0	3	3	6	3	5	2	4	1	1	2	4	1	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:28906499A>T	uc003xhd.3	+	9	1401	c.1059A>T	c.(1057-1059)ATA>ATT	p.I353I	HMBOX1_uc010lvd.2_Silent_p.I353I|HMBOX1_uc003xhc.3_Silent_p.I352I|HMBOX1_uc010lve.2_RNA|HMBOX1_uc003xhe.2_Silent_p.I353I|HMBOX1_uc011lay.1_Silent_p.I352I|HMBOX1_uc003xhf.2_Silent_p.I339I|HMBOX1_uc003xhg.2_Silent_p.I340I	NM_001135726	NP_001129198	Q6NT76	HMBX1_HUMAN	homeobox containing 1	353					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		GTCATGGGATAGATGTGCAGA	0.473													13	127					0	0	0	0	T	28906499	T	T	28906499	2	4	69	1	0	0	0	0	0	0	0	1	7257	410	15	5		5	HMBOX1	8	28906499	Silent	SNP	A	TCGA-CN-6010-01A-11D-1683-08	13386804	28906499	117457523	95	14061											
PEX2	5828	broad.mit.edu	37	chr8	77896369	77896369	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcatccaactggcttattcTtagcactctgtttgcactct	7	16	6	12	0	3	0	0	0	3	0	4	0	4	0	1	1	4	5	1	1	3	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:77896369T>A	uc003yax.2	-	4	504	c.46A>T	c.(46-48)AGA>TGA	p.R16*	PEX2_uc003yay.2_Nonsense_Mutation_p.R16*|PEX2_uc003yaz.2_Nonsense_Mutation_p.R16*	NM_000318	NP_000309	P28328	PEX2_HUMAN	peroxin 2	16					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			ovary(1)	1						TGGCTTATTCTTAGCACTCTG	0.423													14	104					0	0	0	0	A	77896369	A	A	77896369	4	1	69	1	0	0	0	0	0	1	0	0	11800	1617	56	5	875	5	PEX2	8	77896369	Nonsense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	48989870	77896369	68467653	96	14062											
ZNF7	7553	broad.mit.edu	37	chr8	146068464	146068465	+	Missense_Mutation	DNP	GG	TT	TT																															tacaccagagaattcacaccGgggagaagccttataaatgc																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr8:146068464_146068465GG>TT	uc003zeg.3	+	5	2109_2110	c.1972_1973GG>TT	c.(1972-1974)GGG>TTG	p.G658L	ZNF7_uc010mge.2_Missense_Mutation_p.G669L|ZNF7_uc011lln.1_Missense_Mutation_p.G562L|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Missense_Mutation_p.G562L|COMMD5_uc003zel.1_Intron	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	658					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		AATTCACACCGGGGAGAAGCCT	0.386													7	116					0	0	0	0	TT	146068465	TT	TT	146068464	3	4	69	1	0	0	0	0	1	0	0	0	18169	1116	39	3	1986	3	ZNF7	8	146068464	Missense_Mutation	DNP	GG	TCGA-CN-6010-01A-11D-1683-08	68172095	146068464	295558	97	14063											
NFIB	4781	broad.mit.edu	37	chr9	14146797	14146797	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcatctatggatatagttttGggtcttttgctgttaaaata	10	19	8	4	0	3	0	1	0	2	0	3	1	3	1	0	2	1	3	0	2	6	9			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:14146797G>T	uc003zle.2	-	6	1251	c.816C>A	c.(814-816)CCC>CCA	p.P272P	NFIB_uc003zld.2_Silent_p.P20P|NFIB_uc003zlf.2_Silent_p.P272P|NFIB_uc011lmo.1_Silent_p.P272P	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	272					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		ATATAGTTTTGGGTCTTTTGC	0.378			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								10	223					0.00010058	0.00261609	1	0	T	14146797	T	T	14146797	2	4	69	1	0	0	0	0	0	0	0	1	10425	1335	47	4		4	NFIB	9	14146797	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08		14146797	127066634	98	14064											
ELAVL2	1993	broad.mit.edu	37	chr9	23704954	23704954	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatacgagaagtaataatgCgtccatattgtgaaaaaagc	18	9	9	5	2	0	2	0	1	0	1	1	4	1	2	1	0	3	1	1	0	9	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:23704954C>G	uc003zpu.2	-	4	724	c.449G>C	c.(448-450)CGC>CCC	p.R150P	ELAVL2_uc003zps.2_Missense_Mutation_p.R150P|ELAVL2_uc003zpt.2_Missense_Mutation_p.R150P|ELAVL2_uc003zpv.2_Missense_Mutation_p.R150P|ELAVL2_uc003zpw.2_Missense_Mutation_p.R150P	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	150	RRM 2.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		AGTAATAATGCGTCCATATTG	0.423													9	120					0	0	0	0	G	23704954	G	G	23704954	3	3	69	1	0	0	0	0	1	0	0	0	5074	768	27	3	646	3	ELAVL2	9	23704954	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	9558157	23704954	117508477	99	14065											
PLAA	9373	broad.mit.edu	37	chr9	26905576	26905576	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttctgatactgaggaatacTtttttatttgagaatcaaca	13	16	7	5	0	2	3	1	3	1	1	2	5	2	4	0	1	3	1	0	1	6	7			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:26905576T>A	uc003zqd.2	-	14	2746	c.2321A>T	c.(2320-2322)AAG>ATG	p.K774M		NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	774	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		TGAGGAATACTTTTTTATTTG	0.368													24	98					0	0	0	0	A	26905576	A	A	26905576	3	1	69	1	0	0	0	0	1	0	0	0	12066	1609	56	5	70	5	PLAA	9	26905576	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	3200622	26905576	114307855	100	14066											
CEP110	11064	broad.mit.edu	37	chr9	123911032	123911032	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactcctgttagaaaaccacGccctgggcagcaggatggga	12	6	12	11	1	0	1	0	0	0	1	1	3	1	3	3	3	3	3	3	3	4	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr9:123911032G>A	uc004bkx.1	+	22	3573	c.3542G>A	c.(3541-3543)CGC>CAC	p.R1181H	CEP110_uc004bky.1_Missense_Mutation_p.R785H|CEP110_uc004bla.1_Missense_Mutation_p.R629H|CEP110_uc010mvo.1_5'UTR	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1181					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AGAAAACCACGCCCTGGGCAG	0.512													11	56					0	0	0	0	A	123911032	A	A	123911032	3	1	69	1	0	0	0	0	1	0	0	0	3260	1087	38	1	3628	1	CEP110	9	123911032	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	97005456	123911032	17302399	101	14067											
UPF2	26019	broad.mit.edu	37	chr10	12001252	12001253	+	Frame_Shift_Ins	INS	-	T	T																															aggacgtttctttttcacggINSttttttcagctggaggtggg																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:12001252_12001253insT	uc001ila.2	-	11	2761_2762	c.2287_2288insA	c.(2287-2289)ACCfs	p.T763fs	UPF2_uc001ilb.2_Frame_Shift_Ins_p.T763fs|UPF2_uc001ilc.2_Frame_Shift_Ins_p.T763fs|UPF2_uc009xiz.1_Frame_Shift_Ins_p.T763fs	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	763	Sufficient for interaction with UPF3A and UPF3B.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				CTTTTTCACGGTTTTTTCAGCT	0.416													---	---	---								T	12001253	T	T	12001252	7	5	69	1	0	1	1	0	0	0	0	0	17072	1261	44	0	1574	0	UPF2	10	12001252	Frame_Shift_Ins	INS	-	TCGA-CN-6010-01A-11D-1683-08		12001252	123533495	102	14068											
CUBN	8029	broad.mit.edu	37	chr10	16870832	16870832	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtatggtccagaggatggaGagctggcgttgggcccatca	9	8	16	8	1	1	2	1	0	0	2	2	4	2	3	2	5	1	3	2	5	1	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:16870832G>A	uc001ioo.2	-	66	10788	c.10736C>T	c.(10735-10737)TCT>TTT	p.S3579F		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3579	CUB 27.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGAGGATGGAGAGCTGGCGTT	0.433											OREG0020047	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	37					0	0	0	0	A	16870832	A	A	16870832	3	1	69	1	0	0	0	0	1	0	0	0	4068	942	33	2	143	2	CUBN	10	16870832	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	4869580	16870832	118663915	103	14069											
FRMPD2	143162	broad.mit.edu	37	chr10	49409355	49409355	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtccagtaagtatttacTggtcttggctgaatctgtga	9	14	12	6	0	2	2	0	2	2	0	3	3	3	2	1	3	1	3	1	3	4	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:49409355T>A	uc001jgi.2	-	15	1977	c.1870A>T	c.(1870-1872)AGT>TGT	p.S624C	FRMPD2_uc001jgh.2_Missense_Mutation_p.S592C|FRMPD2_uc001jgj.2_Missense_Mutation_p.S602C	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	624	FERM.			S -> G (in Ref. 3; CAH18097).	tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		AAGTATTTACTGGTCTTGGCT	0.448													9	73					0	0	0	0	A	49409355	A	A	49409355	3	1	69	1	0	0	0	0	1	0	0	0	6092	1580	55	5	2119	5	FRMPD2	10	49409355	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	32538523	49409355	86125392	104	14070											
SORCS1	114815	broad.mit.edu	37	chr10	108469071	108469072	+	Missense_Mutation	DNP	CT	AG	AG																															ctgttggcctctgtacagttCtgcattcggcaagttagata																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:108469071_108469072CT>AG	uc001kym.2	-	7	1060_1061	c.1052_1053AG>CT	c.(1051-1053)CAG>CCT	p.Q351P	SORCS1_uc001kyl.2_Missense_Mutation_p.Q351P|SORCS1_uc009xxs.2_Missense_Mutation_p.Q351P|SORCS1_uc001kyn.1_Missense_Mutation_p.Q351P|SORCS1_uc001kyo.2_Missense_Mutation_p.Q351P	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	351	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTGTACAGTTCTGCATTCGGCA	0.386													16	56					0	0	0	0	AG	108469072	AG	AG	108469071	3	1	69	1	0	0	0	0	1	0	0	0	14994	912	32	2	2767	2	SORCS1	10	108469071	Missense_Mutation	DNP	CT	TCGA-CN-6010-01A-11D-1683-08	59059716	108469071	27065676	105	14071											
TIAL1	7073	broad.mit.edu	37	chr10	121336173	121336173	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccgtatactccataaggCggtacttgccacccatttgc	8	11	8	14	2	0	0	0	0	0	0	1	0	1	0	4	2	5	2	4	2	4	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr10:121336173C>T	uc001lei.1	-	11	1515	c.951G>A	c.(949-951)CCG>CCA	p.P317P	TIAL1_uc001leh.1_Silent_p.P295P|TIAL1_uc001lej.1_Silent_p.P334P|TIAL1_uc001lek.1_Silent_p.P194P|TIAL1_uc009xzi.1_Silent_p.P186P|TIAL1_uc010qtb.1_3'UTR	NM_003252	NP_003243	Q01085	TIAR_HUMAN	TIA-1 related protein isoform 1	317					apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		CTCCATAAGGCGGTACTTGCC	0.428													26	103					0	0	0	0	T	121336173	T	T	121336173	2	4	69	1	0	0	0	0	0	0	0	1	15955	755	27	1		1	TIAL1	10	121336173	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	12867102	121336173	14198574	106	14072											
NUP98	4928	broad.mit.edu	37	chr11	3726504	3726504	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agatttcttgagaagtatctGctttggaaggcaggcgactg	10	12	13	6	1	2	2	0	1	2	2	2	5	2	3	0	3	1	3	0	3	3	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:3726504G>A	uc001lyh.2	-	22	3299	c.3008C>T	c.(3007-3009)GCA>GTA	p.A1003V	NUP98_uc001lyi.2_Missense_Mutation_p.A1003V|NUP98_uc001lyg.2_Missense_Mutation_p.A71V	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1020					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AGAAGTATCTGCTTTGGAAGG	0.413			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								26	62					0	0	0	0	A	3726504	A	A	3726504	3	1	69	1	0	0	0	0	1	0	0	0	10827	1319	46	4	2442	4	NUP98	11	3726504	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08		3726504	131280012	107	14073											
ANO5	203859	broad.mit.edu	37	chr11	22279232	22279232	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cttcaatattacaggagatgGaaccttacatgcctctatac	13	12	6	10	0	2	1	1	0	1	1	2	3	2	2	2	2	5	0	2	2	7	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:22279232G>A	uc001mqi.2	+	14	1656	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K	ANO5_uc001mqj.2_Missense_Mutation_p.E446K	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	447	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						ACAGGAGATGGAACCTTACAT	0.378													26	39					0	0	0	0	A	22279232	A	A	22279232	3	1	69	1	0	0	0	0	1	0	0	0	700	1175	41	2	1393	2	ANO5	11	22279232	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	18552728	22279232	112727284	108	14074											
OR5B12	390191	broad.mit.edu	37	chr11	58206944	58206944	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctggcgtccttcaggtgaGcgcatcttcatgatggtgat	6	14	12	9	2	4	3	2	3	2	0	5	3	5	3	1	3	1	1	1	3	0	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:58206944G>C	uc010rkh.1	-	1	681	c.681C>G	c.(679-681)CGC>CGG	p.R227R		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CTTCAGGTGAGCGCATCTTCA	0.398													3	45					0	0	0	0	C	58206944	C	C	58206944	2	2	69	1	0	0	0	0	0	0	0	1	11202	958	34	4		4	OR5B12	11	58206944	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	35927712	58206944	76799572	109	14075											
OR4D11	219986	broad.mit.edu	37	chr11	59271552	59271552	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttgctgcctctccctttCtgtggacccaatgttcttga	4	16	8	13	0	3	1	0	1	3	0	4	2	3	2	3	1	2	3	3	1	1	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:59271552C>A	uc001noa.1	+	1	504	c.504C>A	c.(502-504)TTC>TTA	p.F168L		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTCTCCCTTTCTGTGGACCCA	0.512													19	80					1.40151e-16	4.40108e-15	1	0	A	59271552	A	A	59271552	3	1	69	1	0	0	0	0	1	0	0	0	11109	912	32	2	506	2	OR4D11	11	59271552	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	1064608	59271552	75734964	110	14076											
AHNAK	79026	broad.mit.edu	37	chr11	62297926	62297926	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatcaggcatggagatcttGggggccttgaagtgcatctc	9	10	13	9	0	3	2	1	1	2	1	4	3	3	2	1	4	1	2	1	4	1	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:62297926G>T	uc001ntl.2	-	5	4263	c.3963C>A	c.(3961-3963)CCC>CCA	p.P1321P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1321					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGAGATCTTGGGGGCCTTGA	0.517													33	80					1.03484e-13	3.22994e-12	1	0	T	62297926	T	T	62297926	2	4	69	1	0	0	0	0	0	0	0	1	414	1335	47	4		4	AHNAK	11	62297926	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	3026374	62297926	72708590	111	14077											
MACROD1	28992	broad.mit.edu	37	chr11	63919857	63919857	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcttgtcactcaggccctTcagaaaggctgcagaggcag	9	8	12	12	0	3	2	3	0	0	2	3	2	3	2	1	3	2	4	1	3	1	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:63919857T>G	uc001nyh.2	-	2	426	c.307A>C	c.(307-309)AAG>CAG	p.K103Q		NM_014067	NP_054786	Q9BQ69	MACD1_HUMAN	MACRO domain containing 1	103											0						CTCAGGCCCTTCAGAAAGGCT	0.567													13	47					0	0	0	0	G	63919857	G	G	63919857	3	3	69	1	0	0	0	0	1	0	0	0	9196	1792	62	5	706	5	MACROD1	11	63919857	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	1621931	63919857	71086659	112	14078											
GAL3ST3	89792	broad.mit.edu	37	chr11	65810581	65810581	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgagcgagaaaacctcctcCacctggcggatgaggcccgc	10	4	12	15	4	0	2	0	1	0	1	2	5	2	3	5	3	2	0	5	3	2	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:65810581C>T	uc001ogv.2	-	2	853	c.693G>A	c.(691-693)GTG>GTA	p.V231V	GAL3ST3_uc001ogw.2_Silent_p.V231V	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	231	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1						AAACCTCCTCCACCTGGCGGA	0.662													6	27					0	0	0	0	T	65810581	T	T	65810581	2	4	69	1	0	0	0	0	0	0	0	1	6234	581	21	4		4	GAL3ST3	11	65810581	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	1890724	65810581	69195935	113	14079											
DHCR7	1717	broad.mit.edu	37	chr11	71146483	71146483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagcgctcccagtcccggcCgtacttgctggcgcagcggt	4	8	14	15	5	0	0	0	0	0	0	2	0	2	0	3	3	4	5	3	3	2	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:71146483C>T	uc001oqk.2	-	9	1616	c.1366G>A	c.(1366-1368)GGC>AGC	p.G456S	DHCR7_uc001oql.2_Missense_Mutation_p.G456S	NM_001163817	NP_001157289	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	456					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			ovary(1)|liver(1)	2					NADH(DB00157)	CAGTCCCGGCCGTACTTGCTG	0.657									Smith-Lemli-Opitz_syndrome				10	29					0	0	0	0	T	71146483	T	T	71146483	3	4	69	1	0	0	0	0	1	0	0	0	4499	652	23	1	65	1	DHCR7	11	71146483	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	5335902	71146483	63860033	114	14080											
SLC35F2	54733	broad.mit.edu	37	chr11	107682478	107682478	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctagtcccagcaggatgtacTtccaccattttcttttcaag	9	14	6	12	0	2	0	1	0	1	0	4	1	4	1	3	1	2	2	3	1	3	7			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:107682478T>A	uc001pjq.2	-	3	750	c.329A>T	c.(328-330)AAG>ATG	p.K110M	SLC35F2_uc010rvu.1_Translation_Start_Site|SLC35F2_uc001pjs.2_Missense_Mutation_p.K110M	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	110	Helical; (Potential).				transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		CAGGATGTACTTCCACCATTT	0.418													33	122					0	0	0	0	A	107682478	A	A	107682478	3	1	69	1	0	0	0	0	1	0	0	0	14653	1609	56	5	819	5	SLC35F2	11	107682478	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	36535995	107682478	27324038	115	14081											
PTS	5805	broad.mit.edu	37	chr11	112101363	112101363	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttagattgaccctgctacGggaatggttatgaatctggc	9	13	11	8	1	1	3	0	2	1	1	1	4	1	4	1	3	2	2	1	3	5	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:112101363G>C	uc001pnj.3	+	4	280	c.201G>C	c.(199-201)ACG>ACC	p.T67T	PTS_uc009yyo.2_RNA	NM_000317	NP_000308	Q03393	PTPS_HUMAN	6-pyruvoyltetrahydropterin synthase	67			T -> M (in HPABH4A).		cellular amino acid metabolic process|central nervous system development|tetrahydrobiopterin biosynthetic process	mitochondrion	6-pyruvoyltetrahydropterin synthase activity|metal ion binding				0		all_cancers(61;2.51e-14)|all_epithelial(67;1.64e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.27e-06)|BRCA - Breast invasive adenocarcinoma(274;1.43e-06)|all cancers(92;2.1e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0519)		ACCCTGCTACGGGAATGGTTA	0.383													3	77					0	0	0	0	C	112101363	C	C	112101363	2	2	69	1	0	0	0	0	0	0	0	1	12883	1103	39	3		3	PTS	11	112101363	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	4418885	112101363	22905153	116	14082											
APLP2	334	broad.mit.edu	37	chr11	129996669	129996669	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatgataatgagcatgctCgcttccagaaggctaaggag	13	8	12	8	1	0	4	0	2	0	2	2	5	1	5	1	2	2	4	1	2	3	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:129996669C>A	uc010sby.1	+	8	1322	c.1165C>A	c.(1165-1167)CGC>AGC	p.R389S	APLP2_uc001qfp.2_Missense_Mutation_p.R389S|APLP2_uc001qfq.2_Missense_Mutation_p.R333S|APLP2_uc010sbz.1_Missense_Mutation_p.R177S|APLP2_uc001qfr.2_Missense_Mutation_p.R155S|APLP2_uc001qfs.2_Missense_Mutation_p.R160S|APLP2_uc001qfv.2_Missense_Mutation_p.R280S	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	389	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TGAGCATGCTCGCTTCCAGAA	0.468													7	104					0.000157383	0.00399273	1	0	A	129996669	A	A	129996669	3	1	69	1	0	0	0	0	1	0	0	0	779	884	31	3	1195	3	APLP2	11	129996669	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	17895306	129996669	5009847	117	14083											
SNX19	399979	broad.mit.edu	37	chr11	130785040	130785040	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggccttggaaaagataccCacgagtacaaggtggatcca	13	7	11	10	1	0	1	0	0	0	1	1	4	1	3	3	4	2	1	3	4	5	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr11:130785040C>G	uc001qgk.3	-	1	1343	c.795G>C	c.(793-795)GTG>GTC	p.V265V	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Silent_p.V265V|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	265	PXA.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		AAAAGATACCCACGAGTACAA	0.552													4	65					0	0	0	0	G	130785040	G	G	130785040	2	3	69	1	0	0	0	0	0	0	0	1	14954	581	21	4		4	SNX19	11	130785040	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	788371	130785040	4221476	118	14084											
GALNT8	26290	broad.mit.edu	37	chr12	4835909	4835909	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccagcagaaggcggcccaGgacctcttccggaagtttgg	8	6	14	13	2	1	1	0	0	1	1	2	3	2	3	4	5	1	2	4	5	2	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:4835909G>C	uc001qne.1	+	2	515	c.423G>C	c.(421-423)CAG>CAC	p.Q141H		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	141	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						AGGCGGCCCAGGACCTCTTCC	0.547													4	21					0	0	0	0	C	4835909	C	C	4835909	3	2	69	1	0	0	0	0	1	0	0	0	6254	991	35	4	429	4	GALNT8	12	4835909	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08		4835909	129015986	119	14085											
LTBR	4055	broad.mit.edu	37	chr12	6495602	6495602	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attagagccactgcccccagAgatgtcaggtgagggaccag	11	6	13	11	0	1	3	1	1	0	2	1	5	1	4	4	2	2	0	4	2	1	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:6495602A>G	uc001qny.1	+	6	827	c.659A>G	c.(658-660)GAG>GGG	p.E220G	LTBR_uc010sfc.1_Missense_Mutation_p.E201G|LTBR_uc001qnz.1_Missense_Mutation_p.E215G	NM_002342	NP_002333	P36941	TNR3_HUMAN	lymphotoxin beta receptor precursor	220	Extracellular (Potential).				apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			lung(2)	2						CTGCCCCCAGAGATGTCAGGT	0.547													6	7					0	0	0	0	G	6495602	G	G	6495602	3	3	69	1	0	0	0	0	1	0	0	0	9127	304	11	5	681	5	LTBR	12	6495602	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08	1659693	6495602	127356293	120	14086											
PRH1	5554	broad.mit.edu	37	chr12	11035684	11035684	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tattacgaggggaacatcttCctggctgacatctagaaaag	13	10	10	8	1	2	2	0	1	2	1	3	4	3	3	1	3	2	1	1	3	6	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:11035684C>A	uc001qzc.2	-	6	664	c.76G>T	c.(76-78)GAA>TAA	p.E26*	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_RNA|PRB4_uc001qzf.1_Intron	NM_006250	NP_006241	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1	26	Inhibits hydroxyapatite formation, binds to hydroxyapatite and calcium.					extracellular space	protein binding				0				BRCA - Breast invasive adenocarcinoma(232;0.245)		GGAACATCTTCCTGGCTGACA	0.398													15	54					2.94398e-08	8.86638e-07	1	0	A	11035684	A	A	11035684	4	1	69	1	0	0	0	0	0	1	0	0	12544	864	30	2	436	2	PRH1	12	11035684	Nonsense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	4540082	11035684	122816211	121	14087											
PRB3	5544	broad.mit.edu	37	chr12	11420146	11420146	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttactggggaggctgtccctGgggaggtctgtgtggtctgc	3	12	18	8	0	2	0	0	0	2	0	3	2	3	2	1	7	2	1	1	7	1	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:11420146G>C	uc001qzs.2	-	4	948	c.910C>G	c.(910-912)CAG>GAG	p.Q304E	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	304	Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGCTGTCCCTGGGGAGGTCTG	0.517													14	30					0	0	0	0	C	11420146	C	C	11420146	3	2	69	1	0	0	0	0	1	0	0	0	12506	1357	47	4	23	4	PRB3	12	11420146	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	384462	11420146	122431749	122	14088											
C12orf35	55196	broad.mit.edu	37	chr12	32135423	32135423	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaatcctgtctattctgaaAagcggccaatgccagactca	13	9	7	12	1	3	2	1	1	2	1	4	2	4	2	3	1	2	0	3	1	5	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:32135423A>T	uc001rks.2	+	4	1948	c.1534A>T	c.(1534-1536)AAG>TAG	p.K512*		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	512										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CTATTCTGAAAAGCGGCCAAT	0.388													10	55					0	0	0	0	T	32135423	T	T	32135423	4	4	69	1	0	0	0	0	0	1	0	0	1688	15	1	5	1536	5	C12orf35	12	32135423	Nonsense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08	20715277	32135423	101716472	123	14089											
PDZRN4	29951	broad.mit.edu	37	chr12	41966845	41966845	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccgctcactgtagaccgttCccctgacagttcccttccaa	7	11	6	17	2	1	2	1	1	0	1	5	2	5	2	6	0	0	4	6	0	2	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:41966845C>A	uc010skn.1	+	10	1735	c.1667C>A	c.(1666-1668)TCC>TAC	p.S556Y	PDZRN4_uc001rmq.3_Missense_Mutation_p.S497Y|PDZRN4_uc009zjz.2_Missense_Mutation_p.S495Y|PDZRN4_uc001rmr.2_Missense_Mutation_p.S382Y	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	755							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GTAGACCGTTCCCCTGACAGT	0.498													8	35					1.12685e-05	0.000310336	1	0	A	41966845	A	A	41966845	3	1	69	1	0	0	0	0	1	0	0	0	11764	855	30	2	2375	2	PDZRN4	12	41966845	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	9831422	41966845	91885050	124	14090											
COPZ1	22818	broad.mit.edu	37	chr12	54744287	54744287	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcagccaaagaacagatcAagtggtcactccttcggtga	13	8	10	10	1	3	3	3	1	0	2	5	3	4	3	2	2	2	0	2	2	3	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:54744287A>G	uc001sfs.1	+	9	551	c.514A>G	c.(514-516)AAG>GAG	p.K172E	COPZ1_uc001sft.2_Missense_Mutation_p.K121E|COPZ1_uc009znm.1_Missense_Mutation_p.K180E|COPZ1_uc010sot.1_Missense_Mutation_p.K149E	NM_016057	NP_057141	P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	172					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol					0						AGAACAGATCAAGTGGTCACT	0.493													8	112					0	0	0	0	G	54744287	G	G	54744287	3	3	69	1	0	0	0	0	1	0	0	0	3756	131	5	5	548	5	COPZ1	12	54744287	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08	12777442	54744287	79107608	125	14091											
MON2	23041	broad.mit.edu	37	chr12	62938684	62938684	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatataccttcaggtctgcCagcatccaaactctcgaatg	11	12	6	12	1	3	0	1	0	2	0	5	1	4	0	3	1	4	1	3	1	5	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:62938684C>T	uc001sre.2	+	21	2864	c.2473C>T	c.(2473-2475)CAG>TAG	p.Q825*	MON2_uc009zqj.2_Nonsense_Mutation_p.Q825*|MON2_uc010ssl.1_Nonsense_Mutation_p.Q753*|MON2_uc010ssm.1_Nonsense_Mutation_p.Q802*|MON2_uc010ssn.1_Nonsense_Mutation_p.Q825*|MON2_uc001srf.2_Nonsense_Mutation_p.Q588*	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	826					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TCAGGTCTGCCAGCATCCAAA	0.333													12	40					0	0	0	0	T	62938684	T	T	62938684	4	4	69	1	0	0	0	0	0	1	0	0	9753	595	21	4	2555	4	MON2	12	62938684	Nonsense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	8194397	62938684	70913211	126	14092											
GRIP1	23426	broad.mit.edu	37	chr12	66770984	66770984	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcagaattcctgactgtccGcaggtttccaaatcctccag	9	11	7	14	1	1	2	1	1	0	1	6	2	6	2	5	1	0	2	5	1	2	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:66770984G>A	uc001stk.2	-	20	2788	c.2547C>T	c.(2545-2547)TGC>TGT	p.C849C	GRIP1_uc010sta.1_Silent_p.C793C|GRIP1_uc001stj.2_Silent_p.C631C|GRIP1_uc001stl.1_Silent_p.C741C|GRIP1_uc001stm.2_Silent_p.C849C	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	901					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CTGACTGTCCGCAGGTTTCCA	0.443													37	166					0	0	0	0	A	66770984	A	A	66770984	2	1	69	1	0	0	0	0	0	0	0	1	6826	1079	38	1		1	GRIP1	12	66770984	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	3832300	66770984	67080911	127	14093											
C12orf26	84190	broad.mit.edu	37	chr12	82870447	82870447	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagaaaaaattataatgaacTactacgagaagtataagcct	20	9	6	6	1	0	3	0	1	0	2	0	4	0	3	1	0	4	1	1	0	11	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:82870447T>A	uc001szq.2	+	10	1618	c.1597T>A	c.(1597-1599)TAC>AAC	p.Y533N		NM_032230	NP_115606	Q8N6Q8	CL026_HUMAN	hypothetical protein LOC84190	533											0						TATAATGAACTACTACGAGAA	0.284													18	95					0	0	0	0	A	82870447	A	A	82870447	3	1	69	1	0	0	0	0	1	0	0	0	1685	1522	53	5	1635	5	C12orf26	12	82870447	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	16099463	82870447	50981448	128	14094											
CRY1	1407	broad.mit.edu	37	chr12	107395137	107395137	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagaggataagccatctGtatcaaaacctacaagaaag	17	7	8	9	0	2	2	1	0	1	2	2	3	2	3	2	1	4	2	2	1	7	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:107395137G>T	uc001tmi.3	-	5	1464	c.605C>A	c.(604-606)ACA>AAA	p.T202K		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	202					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						TAAGCCATCTGTATCAAAACC	0.343													5	73					0.000274275	0.00689033	1	0	T	107395137	T	T	107395137	3	4	69	1	0	0	0	0	1	0	0	0	3918	1377	48	4	1187	4	CRY1	12	107395137	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	24524690	107395137	26456758	129	14095											
SFRS8	6433	broad.mit.edu	37	chr12	132238982	132238982	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgtgattgacaagctggcCgagtatgtcgccaggaacgg	9	7	14	11	4	0	2	0	2	0	0	1	4	0	3	3	3	2	2	3	3	3	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr12:132238982C>T	uc001uja.1	+	9	1532	c.1392C>T	c.(1390-1392)GCC>GCT	p.A464A	SFRS8_uc010tbn.1_Silent_p.A464A|SFRS8_uc001ujb.1_Silent_p.A257A|SFRS8_uc001uiz.1_Silent_p.A338A	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	464	SURP motif 2.				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		ACAAGCTGGCCGAGTATGTCG	0.557													4	33					0	0	0	0	T	132238982	T	T	132238982	2	4	69	1	0	0	0	0	0	0	0	1	14248	639	23	1		1	SFRS8	12	132238982	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	24843845	132238982	1612913	130	14096											
BRCA2	675	broad.mit.edu	37	chr13	32971100	32971100	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atactgcatgcaaatgatccCaagtggtccaccccaactaa	14	8	6	13	0	0	1	0	1	0	0	2	1	2	1	4	1	4	2	4	1	5	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr13:32971100C>A	uc001uub.1	+	26	9794	c.9567C>A	c.(9565-9567)CCC>CCA	p.P3189P		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3189					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CAAATGATCCCAAGTGGTCCA	0.378			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			10	192					0.00010058	0.00261609	1	0	A	32971100	A	A	32971100	2	1	69	1	0	0	0	0	0	0	0	1	1504	581	21	4		4	BRCA2	13	32971100	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08		32971100	82198778	131	14097											
POSTN	10631	broad.mit.edu	37	chr13	38138655	38138655	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tactatagccaatacacttaCcttgaacttttttgttggct	10	17	5	9	0	0	1	0	1	0	0	0	1	0	1	2	1	5	2	2	1	7	10			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr13:38138655C>T	uc001uwo.3	-	22	2591	c.2473_splice	c.e22+1	p.G825_splice	POSTN_uc010tet.1_Splice_Site_p.G326_splice|POSTN_uc001uwp.3_Splice_Site_p.G768_splice|POSTN_uc001uwr.2_Splice_Site_p.G770_splice|POSTN_uc001uwq.2_Splice_Site_p.G740_splice	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1						cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		AATACACTTACCTTGAACTTT	0.323													28	96					0	0	0	0	T	38138655	T	T	38138655	5	4	69	1	0	0	0	0	0	0	1	0	12314	521	18	4	44	4	POSTN	13	38138655	Splice_Site	SNP	C	TCGA-CN-6010-01A-11D-1683-08	5167555	38138655	77031223	132	14098											
SLC39A2	29986	broad.mit.edu	37	chr14	21469108	21469109	+	Nonsense_Mutation	DNP	GG	TT	TT																															ccttctttttgtttctagatGgagtatccctatggagagct																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:21469108_21469109GG>TT	uc001vyr.2	+	4	487_488	c.300_301GG>TT	c.(298-303)ATGGAG>ATTTAG	p.100_101ME>I*	SLC39A2_uc001vys.2_Nonsense_Mutation_p.1_2ME>I*	NM_014579	NP_055394	Q9NP94	S39A2_HUMAN	solute carrier family 39 (zinc transporter),	100_101	Extracellular (Potential).					cytoplasmic membrane-bounded vesicle|integral to plasma membrane	zinc ion transmembrane transporter activity			ovary(2)|central_nervous_system(1)	3	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0187)		GTTTCTAGATGGAGTATCCCTA	0.47													14	366					0	0	0	0	TT	21469109	TT	TT	21469108	4	4	69	1	0	0	0	0	0	1	0	0	14682	1348	47	4	314	4	SLC39A2	14	21469108	Nonsense_Mutation	DNP	GG	TCGA-CN-6010-01A-11D-1683-08		21469108	85880432	133	14099											
CHD8	57680	broad.mit.edu	37	chr14	21874023	21874023	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtgagtagcaccttgtgttCctagaaatggaggaaacaaa	14	10	11	6	0	0	2	0	1	0	1	1	4	1	4	2	2	2	3	2	2	5	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:21874023C>A	uc001was.1	-	15	2165	c.2071G>T	c.(2071-2073)GAA>TAA	p.E691*	CHD8_uc001war.1_Nonsense_Mutation_p.E587*|CHD8_uc001wav.1_Nonsense_Mutation_p.E133*	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	970	Helicase ATP-binding.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ACCTTGTGTTCCTAGAAATGG	0.333													18	32					9.16793e-09	2.81041e-07	1	0	A	21874023	A	A	21874023	4	1	69	1	0	0	0	0	0	1	0	0	3346	869	30	2	4933	2	CHD8	14	21874023	Nonsense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	404915	21874023	85475517	134	14100											
DHRS4L1	728635	broad.mit.edu	37	chr14	24511906	24511906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctctccctaggctatgaagCttcatggagttattgatatc	9	14	8	10	0	2	2	1	2	1	0	4	3	2	3	2	2	1	3	2	2	5	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:24511906C>T	uc010alc.2	+	3	316	c.316C>T	c.(316-318)CTT>TTT	p.L106F	DHRS4L1_uc010tnu.1_Intron	NM_001082488	NP_001075957	P0CG22	DR4L1_HUMAN	dehydrogenase/reductase (SDR family) member 4	106							binding|oxidoreductase activity				0						GGCTATGAAGCTTCATGGAGT	0.408													18	98					0	0	0	0	T	24511906	T	T	24511906	3	4	69	1	0	0	0	0	1	0	0	0	4515	797	28	4	326	4	DHRS4L1	14	24511906	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	2637883	24511906	82837634	135	14101											
DDHD1	80821	broad.mit.edu	37	chr14	53527915	53527915	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagccgttcttctatttcctTcagcctaagaaggggtatga	10	13	9	9	1	3	2	1	1	2	1	4	2	4	2	3	2	2	2	3	2	5	7			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:53527915T>C	uc001xai.2	-	8	2001	c.1771A>G	c.(1771-1773)AAG>GAG	p.K591E	DDHD1_uc001xaj.2_Missense_Mutation_p.K598E|DDHD1_uc001xah.2_Missense_Mutation_p.K591E|DDHD1_uc001xag.2_Missense_Mutation_p.K173E|DDHD1_uc001xak.1_5'UTR	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	591					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					TCTATTTCCTTCAGCCTAAGA	0.348													15	79					0	0	0	0	C	53527915	C	C	53527915	3	2	69	1	0	0	0	0	1	0	0	0	4343	1792	62	5	955	5	DDHD1	14	53527915	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	29016009	53527915	53821625	136	14102											
SLC35F4	341880	broad.mit.edu	37	chr14	58060704	58060704	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtccacaaactcctgaggatCcttggttttgaagttcaaga	11	12	9	9	0	1	3	1	2	0	1	4	4	4	4	3	2	1	2	3	2	3	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:58060704C>A	uc001xdb.1	-	2	350	c.350G>T	c.(349-351)GGA>GTA	p.G117V	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_5'UTR	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TCCTGAGGATCCTTGGTTTTG	0.468													7	35					0.000157383	0.00399273	1	0	A	58060704	A	A	58060704	3	1	69	1	0	0	0	0	1	0	0	0	14655	855	30	2	1243	2	SLC35F4	14	58060704	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	4532789	58060704	49288836	137	14103											
SYNE2	23224	broad.mit.edu	37	chr14	64443439	64443439	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atacaagagaaaatgactttAttcaaggttggaaaagaaaa	21	9	8	3	0	1	3	1	1	0	2	1	5	1	4	0	2	1	1	0	2	10	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:64443439A>T	uc001xgm.2	+	12	1517	c.1287A>T	c.(1285-1287)TTA>TTT	p.L429F	SYNE2_uc001xgl.2_Missense_Mutation_p.L429F	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	429	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAATGACTTTATTCAAGGTTG	0.383													14	142					0	0	0	0	T	64443439	T	T	64443439	3	4	69	1	0	0	0	0	1	0	0	0	15512	446	16	5	1329	5	SYNE2	14	64443439	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08	6382735	64443439	42906101	138	14104											
GSC	145258	broad.mit.edu	37	chr14	95234883	95234883	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccctcttctccggtgacGccttcgacgacgacgtcttg	4	12	9	16	6	3	1	0	1	3	0	6	4	4	1	3	1	0	0	3	1	0	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:95234883G>A	uc001ydu.2	-	3	866	c.719C>T	c.(718-720)GCG>GTG	p.A240V		NM_173849	NP_776248	P56915	GSC_HUMAN	goosecoid	240					gastrulation|middle ear morphogenesis		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(154;0.0896)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.202)|Epithelial(152;0.239)		CTCCGGTGACGCCTTCGACGA	0.572													13	105					0	0	0	0	A	95234883	A	A	95234883	3	1	69	1	0	0	0	0	1	0	0	0	6853	1087	38	1	58	1	GSC	14	95234883	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	30791444	95234883	12114657	139	14105											
ATG2B	55102	broad.mit.edu	37	chr14	96772063	96772063	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagggggctttgctcgtatcGgtcttattaacgggcagact	8	12	13	8	3	1	1	0	0	1	1	3	1	1	1	0	4	2	4	0	4	4	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:96772063G>C	uc001yfi.2	-	31	4961	c.4596C>G	c.(4594-4596)ACC>ACG	p.T1532T		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1532										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGCTCGTATCGGTCTTATTAA	0.403													3	48					0	0	0	0	C	96772063	C	C	96772063	2	2	69	1	0	0	0	0	0	0	0	1	1096	1103	39	3		3	ATG2B	14	96772063	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	1537180	96772063	10577477	140	14106											
AK7	122481	broad.mit.edu	37	chr14	96864496	96864496	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgaaaataagtcagctatgCtggaagcttcctcaaccaaa	16	9	7	9	0	2	1	2	1	0	0	3	2	3	2	2	1	4	3	2	1	7	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:96864496C>A	uc001yfn.2	+	2	234	c.190C>A	c.(190-192)CTG>ATG	p.L64M	AK7_uc001yfm.1_Missense_Mutation_p.L64M	NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	64	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GTCAGCTATGCTGGAAGCTTC	0.488													13	72					1.3612e-06	3.89455e-05	1	0	A	96864496	A	A	96864496	3	1	69	1	0	0	0	0	1	0	0	0	444	796	28	4	196	4	AK7	14	96864496	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	92433	96864496	10485044	141	14107											
RAGE	5891	broad.mit.edu	37	chr14	102717262	102717262	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgggtggagatgtattcCgtgtacggctgcttggaata	8	11	15	7	3	0	1	0	0	0	1	1	3	1	2	1	4	3	4	1	4	4	5	rs142858806		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:102717262C>G	uc001ylm.2	-	7	703	c.477G>C	c.(475-477)ACG>ACC	p.T159T	RAGE_uc010txv.1_Silent_p.T129T|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	159	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						AGATGTATTCCGTGTACGGCT	0.557													3	49					0	0	0	0	G	102717262	G	G	102717262	2	3	69	1	0	0	0	0	0	0	0	1	13071	639	23	3		3	RAGE	14	102717262	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	5852766	102717262	4632278	142	14108											
MTA1	9112	broad.mit.edu	37	chr14	105930441	105930441	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgaacggcacgggggcgccGggccagagccctggggctgg	5	3	21	12	4	0	2	0	1	0	1	0	2	0	2	3	7	2	2	3	7	1	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr14:105930441G>T	uc001yqx.2	+	13	1336	c.1149G>T	c.(1147-1149)CCG>CCT	p.P383P	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Silent_p.P144P	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	383					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CGGGGGCGCCGGGCCAGAGCC	0.652													15	40					5.01169e-05	0.00135132	1	0	T	105930441	T	T	105930441	2	4	69	1	0	0	0	0	0	0	0	1	9961	1103	39	3		3	MTA1	14	105930441	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	3213179	105930441	1419099	143	14109											
TGM7	116179	broad.mit.edu	37	chr15	43585695	43585695	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttctgggactggaagggtcGgctgaagctcagccggaggt	7	8	18	8	2	2	1	1	1	1	0	3	4	2	4	1	6	2	3	1	6	2	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:43585695G>T	uc001zrf.1	-	2	150	c.145C>A	c.(145-147)CGA>AGA	p.R49R		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	49					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	TGGAAGGGTCGGCTGAAGCTC	0.617													27	56					1.38267e-23	4.45046e-22	1	0	T	43585695	T	T	43585695	2	4	69	1	0	0	0	0	0	0	0	1	15901	1124	39	3		3	TGM7	15	43585695	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08		43585695	58945697	144	14110											
EFTUD1	79631	broad.mit.edu	37	chr15	82512439	82512439	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttggctcctctccttttGgacatgtttcaatggcactc	5	16	7	13	0	3	0	1	0	2	0	6	1	4	1	2	3	0	3	2	3	1	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:82512439G>T	uc002bgt.1	-	13	1593	c.1424C>A	c.(1423-1425)CCA>CAA	p.P475Q	EFTUD1_uc002bgu.1_Missense_Mutation_p.P424Q	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	475					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						CTCTCCTTTTGGACATGTTTC	0.493													11	121					6.31663e-08	1.88038e-06	1	0	T	82512439	T	T	82512439	3	4	69	1	0	0	0	0	1	0	0	0	4982	1348	47	4	1970	4	EFTUD1	15	82512439	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	38926744	82512439	20018953	145	14111											
ANPEP	290	broad.mit.edu	37	chr15	90347556	90347556	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggaggaggacagggggtcGaacagcagggagttctcccg	9	5	18	9	2	1	0	0	0	1	0	3	5	1	4	1	6	2	2	1	6	1	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:90347556G>A	uc002bop.3	-	6	1399	c.1107C>T	c.(1105-1107)TTC>TTT	p.F369F		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	369	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	ACAGGGGGTCGAACAGCAGGG	0.632													7	28					0	0	0	0	A	90347556	A	A	90347556	2	1	69	1	0	0	0	0	0	0	0	1	710	1049	37	1		1	ANPEP	15	90347556	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	7835117	90347556	12183836	146	14112											
BLM	641	broad.mit.edu	37	chr15	91346911	91346912	+	Nonsense_Mutation	DNP	CG	AT	AT																															gcgatcgcttatgtgatgctCggaaataaagcccaaactgt																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr15:91346911_91346912CG>AT	uc002bpr.2	+	18	3616_3617	c.3519_3520CG>AT	c.(3517-3522)CTCGGA>CTATGA	p.G1174*	BLM_uc010uqh.1_Nonsense_Mutation_p.G1174*|BLM_uc010uqi.1_Nonsense_Mutation_p.G799*|BLM_uc010bnx.2_Intron|BLM_uc002bpt.2_Nonsense_Mutation_p.G149*	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	1174					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			ATGTGATGCTCGGAAATAAAGC	0.317			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				8	213					0	0	0	0	AT	91346912	AT	AT	91346911	4	1	69	1	0	0	0	0	0	1	0	0	1448	871	31	3	3585	3	BLM	15	91346911	Nonsense_Mutation	DNP	CG	TCGA-CN-6010-01A-11D-1683-08	999355	91346911	11184481	147	14113											
RRN3	54700	broad.mit.edu	37	chr16	15157137	15157137	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataggatcaatgaatttcttTgacctgtcaacaaagatcac	15	12	6	8	0	4	3	3	2	1	1	4	4	4	4	1	1	1	0	1	1	5	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:15157137T>G	uc002dde.2	-	17	1778	c.1710A>C	c.(1708-1710)TCA>TCC	p.S570S	PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Silent_p.S438S|RRN3_uc010uzq.1_Silent_p.S540S	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor	570	Interaction with EIF3L.|Interaction with TWISTNB.				regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1						TGAATTTCTTTGACCTGTCAA	0.373													18	96					0	0	0	0	G	15157137	G	G	15157137	2	3	69	1	0	0	0	0	0	0	0	1	13749	1799	63	5		5	RRN3	16	15157137	Silent	SNP	T	TCGA-CN-6010-01A-11D-1683-08		15157137	75197616	148	14114											
CDR2	1039	broad.mit.edu	37	chr16	22360714	22360714	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcagctcctccacttggCtctggaggtgatcaatgttg	7	13	10	11	0	3	1	2	1	1	0	5	2	5	2	2	3	1	3	2	3	1	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:22360714C>T	uc002dkn.2	-	4	700	c.392G>A	c.(391-393)AGC>AAC	p.S131N		NM_001802	NP_001793	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2	131	Potential.					nucleus	protein binding			skin(1)	1				GBM - Glioblastoma multiforme(48;0.0188)		CTCCACTTGGCTCTGGAGGTG	0.527													27	60					0	0	0	0	T	22360714	T	T	22360714	3	4	69	1	0	0	0	0	1	0	0	0	3187	797	28	4	980	4	CDR2	16	22360714	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	7203577	22360714	67994039	149	14115											
SALL1	6299	broad.mit.edu	37	chr16	51173271	51173271	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacaaaccattggcaaactcGcttgggaccgctctctgtgg	9	9	11	12	2	1	0	0	0	1	0	3	2	1	1	2	3	2	3	2	3	2	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:51173271G>A	uc010vgs.1	-	2	2893	c.2862C>T	c.(2860-2862)AGC>AGT	p.S954S	SALL1_uc010vgr.1_Silent_p.S857S|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	954					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGCAAACTCGCTTGGGACCG	0.517													13	22					0	0	0	0	A	51173271	A	A	51173271	2	1	69	1	0	0	0	0	0	0	0	1	13875	1078	38	1		1	SALL1	16	51173271	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	28812557	51173271	39181482	150	14116											
CDH11	1009	broad.mit.edu	37	chr16	65005485	65005485	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaccttagtacaaacctcGgttgtctctgactgtgaaat	11	12	9	9	1	1	2	0	2	1	0	3	3	1	3	2	2	3	2	2	2	5	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:65005485G>A	uc002eoi.2	-	11	2073	c.1639C>T	c.(1639-1641)CGA>TGA	p.R547*	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Nonsense_Mutation_p.R547*|CDH11_uc010vin.1_Nonsense_Mutation_p.R421*	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	547	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TACAAACCTCGGTTGTCTCTG	0.398			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			10	50					0	0	0	0	A	65005485	A	A	65005485	4	1	69	1	0	0	0	0	0	1	0	0	3112	1124	39	1	763	1	CDH11	16	65005485	Nonsense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	13832214	65005485	25349268	151	14117											
DDX19A	55308	broad.mit.edu	37	chr16	70333201	70333201	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccacccgcgcctgggaccAtggccactgactcatgggcc	6	6	11	18	2	1	1	1	1	0	0	2	2	2	2	6	3	0	0	6	3	0	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:70333201A>G	uc002eys.2	+	1	130	c.1A>G	c.(1-3)ATG>GTG	p.M1V	DDX19B_uc010vly.1_Missense_Mutation_p.M1V|DDX19B_uc010vlv.1_Intron|DDX19B_uc010vlw.1_Intron|DDX19B_uc002eyo.2_Missense_Mutation_p.M1V|DDX19B_uc002eyp.2_Missense_Mutation_p.M1V|DDX19B_uc002eyq.2_5'UTR|DDX19B_uc002eyr.2_5'UTR|DDX19B_uc010vlx.1_5'UTR	NM_007242	NP_009173	Q9NUU7	DD19A_HUMAN	DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform	1					mRNA transport|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding				0		Ovarian(137;0.221)				GCCTGGGACCATGGCCACTGA	0.667													3	4					0	0	0	0	G	70333201	G	G	70333201	3	3	69	1	0	0	0	0	1	0	0	0	4363	217	8	5		5	DDX19A	16	70333201	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08	5327716	70333201	20021552	152	14118											
CNTNAP4	85445	broad.mit.edu	37	chr16	76501310	76501310	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttggtggatttcagggatgTatgaggctcatttctatcag	8	15	12	6	0	4	1	3	1	1	0	4	3	4	3	0	4	0	2	0	4	2	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr16:76501310T>A	uc002feu.1	+	12	1930	c.1545T>A	c.(1543-1545)TGT>TGA	p.C515*	CNTNAP4_uc002fev.1_Nonsense_Mutation_p.C379*|CNTNAP4_uc010chb.1_Nonsense_Mutation_p.C442*|CNTNAP4_uc002fex.1_Nonsense_Mutation_p.C518*|CNTNAP4_uc002few.2_Nonsense_Mutation_p.C490*	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	515	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TTCAGGGATGTATGAGGCTCA	0.433													11	25					0	0	0	0	A	76501310	A	A	76501310	4	1	69	1	0	0	0	0	0	1	0	0	3664	1644	57	5	1596	5	CNTNAP4	16	76501310	Nonsense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	6168109	76501310	13853443	153	14119											
ASGR2	433	broad.mit.edu	37	chr17	7017444	7017444	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgcacacttgcctttcaaaAatggatttcctctcctggga	9	13	7	12	0	2	0	1	0	1	0	4	2	3	2	3	2	2	1	3	2	2	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:7017444A>G	uc002gep.3	-	2	381	c.116T>C	c.(115-117)TTT>TCT	p.F39S	ASGR2_uc002gem.1_5'UTR|ASGR2_uc002gen.1_Intron|ASGR2_uc002geo.1_Missense_Mutation_p.F39S|ASGR2_uc002ger.3_Missense_Mutation_p.F39S|ASGR2_uc002geq.3_Intron|ASGR2_uc010clw.2_Intron|ASGR2_uc010vtl.1_Intron	NM_001181	NP_001172	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2 isoform a	39	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			ovary(1)	1					Antihemophilic Factor(DB00025)	GCCTTTCAAAAATGGATTTCC	0.537													10	46					0	0	0	0	G	7017444	G	G	7017444	3	3	69	1	0	0	0	0	1	0	0	0	1042	14	1	5	851	5	ASGR2	17	7017444	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08		7017444	74177766	154	14120											
TP53	7157	broad.mit.edu	37	chr17	7579312	7579312	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccctcagggcaactgacCgtgcaagtcacagacttggc	10	6	11	14	1	2	2	2	1	0	1	2	2	2	2	3	2	3	2	3	2	2	1	rs55863639		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:7579312C>A	uc002gim.2	-	4	569	c.375G>T	c.(373-375)ACG>ACT	p.T125T	TP53_uc002gig.1_Silent_p.T125T|TP53_uc002gih.2_Silent_p.T125T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Silent_p.T125T|TP53_uc010cni.1_Silent_p.T125T|TP53_uc002gij.2_Silent_p.T125T|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Silent_p.T86T|TP53_uc010cnk.1_Silent_p.T140T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	125	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in a sporadic cancer; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(15)|p.0?(7)|p.T125M(7)|p.T125K(3)|p.T125R(3)|p.?(2)|p.V73fs*9(1)|p.T125P(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.T125fs*45(1)|p.T125fs*24(1)|p.T125A(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	25					2.94398e-08	8.86638e-07	1	0	A	7579312	A	A	7579312	2	1	69	1	0	0	0	0	0	0	0	1	16448	666	23	3		3	TP53	17	7579312	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	561868	7579312	73615898	155	14121											
RHBDL3	162494	broad.mit.edu	37	chr17	30621436	30621436	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcacaggtttggcgctacCtgacatacatcttcatgcat	10	11	9	11	1	2	1	1	1	1	0	2	2	2	1	1	2	4	4	1	2	2	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:30621436C>A	uc002hhe.1	+	5	657	c.643C>A	c.(643-645)CTG>ATG	p.L215M	RHBDL3_uc010csw.1_Missense_Mutation_p.L207M|RHBDL3_uc010csx.1_Missense_Mutation_p.L215M|RHBDL3_uc010csy.1_Missense_Mutation_p.L117M|RHBDL3_uc002hhf.1_Missense_Mutation_p.L117M	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	215					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				TTGGCGCTACCTGACATACAT	0.463													9	36					1.12685e-05	0.000310336	1	0	A	30621436	A	A	30621436	3	1	69	1	0	0	0	0	1	0	0	0	13388	680	24	4	661	4	RHBDL3	17	30621436	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	23042124	30621436	50573774	156	14122											
C17orf66	256957	broad.mit.edu	37	chr17	34185928	34185928	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagtccttggcacaggcaCtgcaacaagaactcttggac	11	9	10	11	0	1	2	0	1	1	1	2	3	2	3	1	3	3	3	1	3	3	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:34185928C>T	uc002hke.1	-	9	1052	c.903G>A	c.(901-903)CAG>CAA	p.Q301Q	C17orf66_uc010wck.1_RNA|C17orf66_uc010wcl.1_Silent_p.Q261Q|C17orf66_uc010wcm.1_Silent_p.Q267Q	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957	301							binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GGCACAGGCACTGCAACAAGA	0.567													9	55					0	0	0	0	T	34185928	T	T	34185928	2	4	69	1	0	0	0	0	0	0	0	1	1881	564	20	4		4	C17orf66	17	34185928	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	3564492	34185928	47009282	157	14123											
SOCS7	30837	broad.mit.edu	37	chr17	36508743	36508743	+	Frame_Shift_Del	DEL	C	-	-																															ggccactcgcgggtccttctCggaagggctccttcaaaatc																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:36508743delC	uc002hqa.2	+	1	739	c.616delC	c.(616-618)CGGfs	p.R206fs	SOCS7_uc010cvl.2_Frame_Shift_Del_p.R206fs|SOCS7_uc002hqb.2_RNA	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	206	Mediates interaction with SORBS3.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					GGGTCCTTCTCGGAAGGGCTC	0.617													---	---	---								-	36508743	-	-	36508743	7	5	69	1	0	1	0	1	0	0	0	0	14983	875	31	0	618	0	SOCS7	17	36508743	Frame_Shift_Del	DEL	C	TCGA-CN-6010-01A-11D-1683-08	2322815	36508743	44686467	158	14124											
HSPB9	94086	broad.mit.edu	37	chr17	40275302	40275302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccaaacaggaccgtcccCgagactcgggagcctcggct	9	4	12	16	4	0	1	0	0	0	1	3	4	1	3	5	3	3	1	5	3	1	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:40275302C>T	uc002hyy.2	+	1	547	c.434C>T	c.(433-435)CCG>CTG	p.P145L	KAT2A_uc002hyx.2_5'Flank	NM_033194	NP_149971	Q9BQS6	HSPB9_HUMAN	heat shock protein, alpha-crystallin-related,	145					response to stress	cytoplasm|nucleus	protein binding				0		all_cancers(22;0.00064)|Breast(137;0.00104)|all_epithelial(22;0.00866)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GGACCGTCCCCGAGACTCGGG	0.637													9	26					0	0	0	0	T	40275302	T	T	40275302	3	4	69	1	0	0	0	0	1	0	0	0	7463	652	23	1	436	1	HSPB9	17	40275302	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	3766559	40275302	40919908	159	14125											
TUBG1	7283	broad.mit.edu	37	chr17	40766632	40766632	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacctgccctcggcccaccGggtcagcgggctcatgatgg	5	7	13	16	3	2	1	2	1	0	0	3	1	2	1	4	4	3	1	4	4	1	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:40766632G>A	uc002ian.2	+	10	1513	c.1115G>A	c.(1114-1116)CGG>CAG	p.R372Q		NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	372					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TCGGCCCACCGGGTCAGCGGG	0.592													15	45					0	0	0	0	A	40766632	A	A	40766632	3	1	69	1	0	0	0	0	1	0	0	0	16832	1116	39	1	1153	1	TUBG1	17	40766632	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	491330	40766632	40428578	160	14126											
CCDC47	57003	broad.mit.edu	37	chr17	61843274	61843274	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taataaaaagagcctcacctGggtatctgcatcttcaaaat	15	11	6	9	0	4	1	2	0	2	1	4	1	4	1	2	1	2	2	2	1	7	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:61843274G>T	uc002jbs.3	-	2	598	c.262C>A	c.(262-264)CAG>AAG	p.Q88K	CCDC47_uc010ddx.2_Missense_Mutation_p.Q88K|CCDC47_uc002jbt.2_Missense_Mutation_p.Q88K	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	88						integral to membrane	protein binding				0						AGCCTCACCTGGGTATCTGCA	0.393													12	215					0.00010058	0.00261609	1	0	T	61843274	T	T	61843274	3	4	69	1	0	0	0	0	1	0	0	0	2831	1357	47	4	1237	4	CCDC47	17	61843274	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	21076642	61843274	19351936	161	14127											
RNF213	57674	broad.mit.edu	37	chr17	78319551	78319551	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggctgaaaatgtggccttCgccaataaggaccaacatca	14	7	10	10	1	1	1	1	1	0	0	2	3	1	2	3	3	1	1	3	3	5	2	rs143772929		TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr17:78319551C>T	uc002jyh.1	+	4	1858	c.1635C>T	c.(1633-1635)TTC>TTT	p.F545F		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATGTGGCCTTCGCCAATAAGG	0.463													12	50					0	0	0	0	T	78319551	T	T	78319551	2	4	69	1	0	0	0	0	0	0	0	1	13542	883	31	1		1	RNF213	17	78319551	Silent	SNP	C	TCGA-CN-6010-01A-11D-1683-08	16476277	78319551	2875659	162	14128											
PTPRM	5797	broad.mit.edu	37	chr18	8143677	8143677	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgaaaccagtcccagaacccGagaaacagacagaccataca	18	2	7	14	2	0	4	0	0	0	4	1	6	1	4	4	0	4	0	4	0	4	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr18:8143677G>A	uc002knn.3	+	14	2703	c.2200G>A	c.(2200-2202)GAG>AAG	p.E734K	PTPRM_uc010dkv.2_Missense_Mutation_p.E734K|PTPRM_uc010wzl.1_Missense_Mutation_p.E521K	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	734	Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CCCAGAACCCGAGAAACAGAC	0.423													12	60					0	0	0	0	A	8143677	A	A	8143677	3	1	69	1	0	0	0	0	1	0	0	0	12871	1059	37	1	2254	1	PTPRM	18	8143677	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08		8143677	69933571	163	14129											
MYO5B	4645	broad.mit.edu	37	chr18	47421488	47421488	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcagccgctctacctccatGgtgtatgttgaggtggtcac	6	13	11	11	1	3	1	2	1	1	0	4	1	4	1	3	3	2	3	3	3	2	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr18:47421488G>C	uc002leb.2	-	22	3156	c.2868C>G	c.(2866-2868)ACC>ACG	p.T956T	MYO5B_uc002lea.2_Silent_p.T97T	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	956	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CTACCTCCATGGTGTATGTTG	0.552													3	37					0	0	0	0	C	47421488	C	C	47421488	2	2	69	1	0	0	0	0	0	0	0	1	10132	1335	47	4		4	MYO5B	18	47421488	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	39277811	47421488	30655760	164	14130											
SHC2	25759	broad.mit.edu	37	chr19	436383	436383	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccccgggggcctcacctcTctggttgatggggtccttgg	2	11	14	14	1	2	1	1	1	1	0	5	1	4	1	5	6	0	1	5	6	0	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:436383T>C	uc002loq.3	-	6	823	c.823A>G	c.(823-825)AGA>GGA	p.R275G	SHC2_uc002lop.3_Missense_Mutation_p.R16G	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	275	PID.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTCACCTCTCTGGTTGATG	0.716													9	16					0	0	0	0	C	436383	C	C	436383	3	2	69	1	0	0	0	0	1	0	0	0	14336	1559	54	5	953	5	SHC2	19	436383	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08		436383	58692600	165	14131											
MUC16	94025	broad.mit.edu	37	chr19	9069845	9069845	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcctgtgagatagtccctatAggacctgtttggttggtgat	7	14	13	7	0	0	2	0	2	0	1	1	4	1	3	3	3	0	2	3	3	3	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:9069845A>G	uc002mkp.2	-	3	17805	c.17601T>C	c.(17599-17601)CCT>CCC	p.P5867P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5869	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAGTCCCTATAGGACCTGTTT	0.493													3	79					0	0	0	0	G	9069845	G	G	9069845	2	3	69	1	0	0	0	0	0	0	0	1	10026	407	15	5		5	MUC16	19	9069845	Silent	SNP	A	TCGA-CN-6010-01A-11D-1683-08	8633462	9069845	50059138	166	14132											
KEAP1	9817	broad.mit.edu	37	chr19	10610177	10610177	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcattgctggggtccagcTgctgcaccaggaagtcactg	7	9	14	11	0	1	0	1	0	0	0	2	1	2	1	2	4	4	5	2	4	1	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:10610177T>A	uc002moq.1	-	2	689	c.533A>T	c.(532-534)CAG>CTG	p.Q178L	KEAP1_uc002mor.1_Missense_Mutation_p.Q178L	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GGGGTCCAGCTGCTGCACCAG	0.567													6	9					0	0	0	0	A	10610177	A	A	10610177	3	1	69	1	0	0	0	0	1	0	0	0	8180	1580	55	5	1361	5	KEAP1	19	10610177	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	1540332	10610177	48518806	167	14133											
SIN3B	23309	broad.mit.edu	37	chr19	16977273	16977273	+	Frame_Shift_Del	DEL	C	-	-																															tgagaaggcgtacctcaagtCccttgaccaccaggctgtga																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:16977273delC	uc002ney.1	+	13	1822	c.1808delC	c.(1807-1809)TCCfs	p.S603fs	SIN3B_uc002nez.1_Frame_Shift_Del_p.S571fs|SIN3B_uc010xpi.1_Frame_Shift_Del_p.S161fs	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	603					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						TACCTCAAGTCCCTTGACCAC	0.587													---	---	---								-	16977273	-	-	16977273	7	5	69	1	0	1	0	1	0	0	0	0	14391	855	30	0	1858	0	SIN3B	19	16977273	Frame_Shift_Del	DEL	C	TCGA-CN-6010-01A-11D-1683-08	6367096	16977273	42151710	168	14134											
PLVAP	83483	broad.mit.edu	37	chr19	17476149	17476149	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatggccagctccatcctGagctgctccgcctccctctt	4	11	8	18	1	1	2	0	2	1	0	5	2	5	2	6	1	3	3	6	1	0	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:17476149G>T	uc002ngk.1	-	3	1175	c.1125C>A	c.(1123-1125)CTC>CTA	p.L375L		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	375	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						GCTCCATCCTGAGCTGCTCCG	0.617													15	40					8.00594e-06	0.000225304	1	0	T	17476149	T	T	17476149	2	4	69	1	0	0	0	0	0	0	0	1	12171	1277	45	2		2	PLVAP	19	17476149	Silent	SNP	G	TCGA-CN-6010-01A-11D-1683-08	498876	17476149	41652834	169	14135											
SF4	57794	broad.mit.edu	37	chr19	19416690	19416690	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccactgctcatagtcctccTcctcgtcctcgtcaggggac	5	10	9	17	2	2	0	2	0	0	0	8	1	6	1	5	2	1	1	5	2	1	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:19416690T>C	uc002nmh.2	-	4	508	c.506A>G	c.(505-507)GAG>GGG	p.E169G	SF4_uc002nmg.2_5'Flank|SF4_uc002nmi.2_5'UTR|SF4_uc002nmj.2_5'UTR|SF4_uc010xqr.1_RNA|SF4_uc010xqs.1_RNA	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	169					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						ATAGTCCTCCTCCTCGTCCTC	0.647													6	31					0	0	0	0	C	19416690	C	C	19416690	3	2	69	1	0	0	0	0	1	0	0	0	14220	1551	54	5	1475	5	SF4	19	19416690	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	1940541	19416690	39712293	170	14136											
PSG8	440533	broad.mit.edu	37	chr19	43262160	43262160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaaaatactcacggaggaGattcagggtgaatgggtcac	14	7	13	7	1	3	3	3	1	0	2	3	5	3	4	0	4	1	0	0	4	4	2			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:43262160G>A	uc002ouo.2	-	3	801	c.703C>T	c.(703-705)CTC>TTC	p.L235F	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Missense_Mutation_p.L74F|PSG8_uc002ouh.2_Missense_Mutation_p.L235F|PSG8_uc010ein.2_Missense_Mutation_p.L113F|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Missense_Mutation_p.L74F|PSG8_uc002oul.3_Missense_Mutation_p.L235F|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	235						extracellular region					0		Prostate(69;0.00899)				TCACGGAGGAGATTCAGGGTG	0.527													24	117					0	0	0	0	A	43262160	A	A	43262160	3	1	69	1	0	0	0	0	1	0	0	0	12723	942	33	2	610	2	PSG8	19	43262160	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	23845470	43262160	15866823	171	14137											
ZNF229	7772	broad.mit.edu	37	chr19	44934288	44934288	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caacatgacaagatatccagCaaaagctgtcatcatcccag	16	7	6	12	0	2	2	2	1	0	1	4	2	4	2	2	0	3	2	2	0	5	1			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:44934288C>G	uc002oze.1	-	6	1102	c.668G>C	c.(667-669)TGC>TCC	p.C223S	ZNF229_uc010ejk.1_5'UTR|ZNF229_uc010ejl.1_Missense_Mutation_p.C217S	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				AGATATCCAGCAAAAGCTGTC	0.378													5	94					0	0	0	0	G	44934288	G	G	44934288	3	3	69	1	0	0	0	0	1	0	0	0	17849	710	25	4	1813	4	ZNF229	19	44934288	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	1672128	44934288	14194695	172	14138											
ZNF577	84765	broad.mit.edu	37	chr19	52383578	52383578	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagcaatgacaaatttacctCccctgaagaactgccttgct	12	10	6	13	0	0	3	0	2	0	1	1	3	1	3	4	0	5	2	4	0	5	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:52383578C>G	uc010yde.1	-	4	449	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	ZNF577_uc010ydd.1_RNA|ZNF577_uc002pxx.3_Missense_Mutation_p.E20Q|ZNF577_uc002pxv.2_Missense_Mutation_p.E13Q|ZNF577_uc002pxw.2_Missense_Mutation_p.E13Q	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		aaatttacctcccctgaagaa	0.03													22	110					0	0	0	0	G	52383578	G	G	52383578	3	3	69	1	0	0	0	0	1	0	0	0	18076	864	30	2	1415	2	ZNF577	19	52383578	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	7449290	52383578	6745405	173	14139											
ZNF649	65251	broad.mit.edu	37	chr19	52394790	52394790	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggggtttctttcctgtaTgaattctcttatgctcagtg	5	18	10	8	1	3	1	1	1	2	0	5	1	4	1	1	2	1	3	1	2	3	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:52394790T>C	uc002pxy.2	-	5	867	c.599A>G	c.(598-600)CAT>CGT	p.H200R	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	200	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTTTCCTGTATGAATTCTCTT	0.463													11	45					0	0	0	0	C	52394790	C	C	52394790	3	2	69	1	0	0	0	0	1	0	0	0	18131	1464	51	5	922	5	ZNF649	19	52394790	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08	11212	52394790	6734193	174	14140											
CACNG8	59283	broad.mit.edu	37	chr19	54466610	54466610	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccccaccgcgggggcggcGgcgcctcggagaagaaggac	7	1	17	16	6	0	2	0	0	0	2	1	4	0	3	5	6	0	0	5	6	2	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:54466610G>A	uc002qcs.1	+	1	317	c.211G>A	c.(211-213)GGC>AGC	p.G71S		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	72					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		CGGGGGCGGCGGCGCCTCGGA	0.726													3	7					0	0	0	0	A	54466610	A	A	54466610	3	1	69	1	0	0	0	0	1	0	0	0	2575	1116	39	1	216	1	CACNG8	19	54466610	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	2071820	54466610	4662373	175	14141											
LILRB3	11025	broad.mit.edu	37	chr19	54746049	54746049	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccagtgggttatttctgtCcaagggctctgggcttccct	4	15	11	11	0	2	0	0	0	2	0	5	0	5	0	3	3	0	3	3	3	2	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:54746049C>A	uc010erh.1	-	3	332	c.208G>T	c.(208-210)GAC>TAC	p.D70Y	LILRA6_uc002qew.1_Missense_Mutation_p.D70Y|LILRB3_uc002qeh.1_Missense_Mutation_p.D70Y|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Missense_Mutation_p.D70Y|LILRA6_uc002qek.1_Missense_Mutation_p.D70Y|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Missense_Mutation_p.D70Y|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.D70Y|LILRB3_uc002qep.1_Missense_Mutation_p.D70Y|LILRB3_uc002qeq.1_Missense_Mutation_p.D70Y|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.D70Y|LILRA6_uc010yep.1_Missense_Mutation_p.D70Y|LILRA6_uc010yeq.1_Missense_Mutation_p.D70Y|LILRA6_uc002qet.3_RNA|LILRA6_uc002qeu.1_Missense_Mutation_p.D70Y|LILRA6_uc002qev.1_5'Flank	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	70	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTATTTCTGTCCAAGGGCTCT	0.567													18	147					2.98393e-07	8.68206e-06	1	0	A	54746049	A	A	54746049	3	1	69	1	0	0	0	0	1	0	0	0	8833	855	30	2		2	LILRB3	19	54746049	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	279439	54746049	4382934	176	14142											
PTPRH	5794	broad.mit.edu	37	chr19	55718094	55718094	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccacagagctatttacTccgtctttctccacccacac	8	11	4	18	1	2	1	0	0	2	1	5	1	4	1	5	0	2	1	5	0	2	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:55718094T>A	uc002qjq.2	-	3	388	c.315A>T	c.(313-315)GGA>GGT	p.G105G	PTPRH_uc010esv.2_Silent_p.G105G|PTPRH_uc002qjs.2_Silent_p.G112G	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	105	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		AGCTATTTACTCCGTCTTTCT	0.498													14	80					0	0	0	0	A	55718094	A	A	55718094	2	1	69	1	0	0	0	0	0	0	0	1	12868	1538	54	5		5	PTPRH	19	55718094	Silent	SNP	T	TCGA-CN-6010-01A-11D-1683-08	972045	55718094	3410889	177	14143											
PEG3	5178	broad.mit.edu	37	chr19	57328305	57328305	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccttacattcaaaacgtttcCctccaacctgacttttctga	10	14	3	14	1	2	2	1	2	1	0	4	2	4	2	4	0	3	1	4	0	4	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr19:57328305C>T	uc002qnu.2	-	7	1856	c.1505G>A	c.(1504-1506)GGG>GAG	p.G502E	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G473E|PEG3_uc002qnv.2_Missense_Mutation_p.G502E|PEG3_uc002qnw.2_Missense_Mutation_p.G378E|PEG3_uc002qnx.2_Missense_Mutation_p.G376E|PEG3_uc010etr.2_Missense_Mutation_p.G502E	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	502					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AAAACGTTTCCCTCCAACCTG	0.453													15	83					0	0	0	0	T	57328305	T	T	57328305	3	4	69	1	0	0	0	0	1	0	0	0	11774	623	22	4	3265	4	PEG3	19	57328305	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	1610211	57328305	1800678	178	14144											
XRN2	22803	broad.mit.edu	37	chr20	21336733	21336733	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctagccagaagaaacagccTtggaggtgatgtcttatttg	11	11	11	8	0	1	3	0	1	1	2	1	4	1	4	3	2	3	0	3	2	4	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr20:21336733T>C	uc002wsf.1	+	22	2131	c.2036T>C	c.(2035-2037)CTT>CCT	p.L679P	XRN2_uc002wsg.1_Missense_Mutation_p.L603P|XRN2_uc010zsk.1_Missense_Mutation_p.L625P	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	679					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						AGAAACAGCCTTGGAGGTGAT	0.403													7	55					0	0	0	0	C	21336733	C	C	21336733	3	2	69	1	0	0	0	0	1	0	0	0	17528	1609	56	5	2122	5	XRN2	20	21336733	Missense_Mutation	SNP	T	TCGA-CN-6010-01A-11D-1683-08		21336733	41688787	179	14145											
TH1L	51497	broad.mit.edu	37	chr20	57564012	57564012	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gattgcacataccacgtggcGggaccttttttataaactgg	10	12	10	9	2	0	0	0	0	0	0	0	2	0	1	2	3	3	1	2	3	4	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr20:57564012G>C	uc002yag.2	+	5	494	c.467G>C	c.(466-468)CGG>CCG	p.R156P	TH1L_uc010zzu.1_Missense_Mutation_p.R156P|TH1L_uc002yaf.1_RNA|TH1L_uc002yah.2_Missense_Mutation_p.R156P	NM_198976	NP_945327	Q8IXH7	NELFD_HUMAN	TH1-like protein	156					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)			ACCACGTGGCGGGACCTTTTT	0.478													3	46					0	0	0	0	C	57564012	C	C	57564012	3	2	69	1	0	0	0	0	1	0	0	0	15905	1116	39	3	485	3	TH1L	20	57564012	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	36227279	57564012	5461508	180	14146											
TTC3	7267	broad.mit.edu	37	chr21	38516833	38516833	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatgactttagatttctagAagctctcaatcactttgaga	12	16	6	7	0	3	4	2	2	2	3	4	5	3	4	0	0	1	1	0	0	5	6			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr21:38516833A>C	uc002yvz.2	+	21	1886	c.1781A>C	c.(1780-1782)GAA>GCA	p.E594A	TTC3_uc011aee.1_Missense_Mutation_p.E284A|TTC3_uc002ywa.2_Missense_Mutation_p.E594A|TTC3_uc002ywb.2_Missense_Mutation_p.E594A|TTC3_uc010gnf.2_Missense_Mutation_p.E359A|TTC3_uc002ywc.2_Missense_Mutation_p.E284A|TTC3_uc011aed.1_Missense_Mutation_p.E284A|TTC3_uc010gne.1_Missense_Mutation_p.E594A	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	594	TPR 4.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				AGATTTCTAGAAGCTCTCAAT	0.373													25	83					0	0	0	0	C	38516833	C	C	38516833	3	2	69	1	0	0	0	0	1	0	0	0	16765	246	9	5	1859	5	TTC3	21	38516833	Missense_Mutation	SNP	A	TCGA-CN-6010-01A-11D-1683-08		38516833	9613062	181	14147											
IGSF5	150084	broad.mit.edu	37	chr21	41151062	41151063	+	Missense_Mutation	DNP	CG	AT	AT																															aggtgtattatcaagtttacCgagtttaggtttttcattgc																										TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr21:41151062_41151063CG>AT	uc002yyo.2	+	5	867_868	c.764_765CG>AT	c.(763-765)CCG>CAT	p.P255H		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	255	Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				TCAAGTTTACCGAGTTTAGGTT	0.381													5	68					0	0	0	0	AT	41151063	AT	AT	41151062	3	1	69	1	0	0	0	0	1	0	0	0	7641	652	23	3	782	3	IGSF5	21	41151062	Missense_Mutation	DNP	CG	TCGA-CN-6010-01A-11D-1683-08	2634229	41151062	6978833	182	14148											
NEFH	4744	broad.mit.edu	37	chr22	29885318	29885318	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggcaaagtcaccgcctgaGgccaagtccccagagaagga	13	3	13	12	1	1	2	1	1	0	1	2	5	2	3	5	3	0	1	5	3	3	0			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr22:29885318G>T	uc003afo.2	+	4	1760	c.1689G>T	c.(1687-1689)GAG>GAT	p.E563D	NEFH_uc003afp.2_Intron	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	563	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|5.|Tail.				cell death|nervous system development	neurofilament					0						CACCGCCTGAGGCCAAGTCCC	0.572													6	39					2.0095e-06	5.68622e-05	1	0	T	29885318	T	T	29885318	3	4	69	1	0	0	0	0	1	0	0	0	10368	991	35	4	1703	4	NEFH	22	29885318	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08		29885318	21419248	183	14149											
DEPDC5	9681	broad.mit.edu	37	chr22	32200153	32200153	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttttctttttttaggaattGgtgtggatttggtgtgcatg	5	21	12	3	0	1	0	0	0	1	0	1	2	1	2	0	4	1	1	0	4	2	8			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chr22:32200153G>T	uc003als.2	+	16	1229	c.1087G>T	c.(1087-1089)GGT>TGT	p.G363C	DEPDC5_uc011als.1_Missense_Mutation_p.G363C|DEPDC5_uc011alu.1_Missense_Mutation_p.G363C|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.G363C|DEPDC5_uc003alr.1_Missense_Mutation_p.G363C|DEPDC5_uc011alt.1_Missense_Mutation_p.G335C	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	363					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						TTTAGGAATTGGTGTGGATTT	0.393													7	69					8.12818e-05	0.00214667	1	0	T	32200153	T	T	32200153	3	4	69	1	0	0	0	0	1	0	0	0	4464	1348	47	4	1145	4	DEPDC5	22	32200153	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	2314835	32200153	19104413	184	14150											
PCDH11X	27328	broad.mit.edu	37	chrX	91132758	91132758	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agatcaattacctgctaggcCctgatgctccacctgaattc	10	11	7	13	0	1	3	1	2	0	1	3	3	2	3	4	1	3	2	4	1	4	3			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:91132758C>A	uc004efk.1	+	2	2364	c.1519C>A	c.(1519-1521)CCT>ACT	p.P507T	PCDH11X_uc004efl.1_Missense_Mutation_p.P507T|PCDH11X_uc004efo.1_Missense_Mutation_p.P507T|PCDH11X_uc010nmv.1_Missense_Mutation_p.P507T|PCDH11X_uc004efm.1_Missense_Mutation_p.P507T|PCDH11X_uc004efn.1_Missense_Mutation_p.P507T|PCDH11X_uc004efh.1_Missense_Mutation_p.P507T|PCDH11X_uc004efj.1_Missense_Mutation_p.P507T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	507	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CCTGCTAGGCCCTGATGCTCC	0.423													12	10					1.08611e-07	3.19626e-06	1	0	A	91132758	A	A	91132758	3	1	69	1	0	0	0	0	1	0	0	0	11562	623	22	4	1525	4	PCDH11X	23	91132758	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08		91132758	64137802	185	14151											
GPRASP2	114928	broad.mit.edu	37	chrX	101969805	101969805	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtaacttgtaccatgactgGggcagagattgagcctagtg	10	11	13	7	0	0	3	0	2	0	1	0	4	0	3	2	2	3	3	2	2	3	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:101969805G>C	uc004ejk.2	+	4	1342	c.8G>C	c.(7-9)GGG>GCG	p.G3A	GPRASP2_uc004ejl.2_Missense_Mutation_p.G3A|GPRASP2_uc004ejm.2_Missense_Mutation_p.G3A|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	3						cytoplasm	protein binding			ovary(1)	1						accatgactGGGGCAGAGATT	0.294													3	39					0	0	0	0	C	101969805	C	C	101969805	3	2	69	1	0	0	0	0	1	0	0	0	6762	1232	43	4	10	4	GPRASP2	23	101969805	Missense_Mutation	SNP	G	TCGA-CN-6010-01A-11D-1683-08	10837047	101969805	53300755	186	14152											
CHRDL1	91851	broad.mit.edu	37	chrX	109919483	109919483	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtggcccttttcagatctCtccaggtacaaaaccttgac	10	11	7	13	0	2	2	1	1	1	1	4	2	3	2	3	2	2	1	3	2	3	4			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:109919483C>A	uc004eou.3	-	12	1702	c.1353G>T	c.(1351-1353)GAG>GAT	p.E451D	CHRDL1_uc004eov.2_Missense_Mutation_p.E440D|CHRDL1_uc004eow.2_Missense_Mutation_p.E449D|CHRDL1_uc010nps.2_Missense_Mutation_p.E450D|CHRDL1_uc004eot.2_Missense_Mutation_p.E370D|CHRDL1_uc011mss.1_Missense_Mutation_p.E365D	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	443					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						TTTCAGATCTCTCCAGGTACA	0.448													29	44					2.46105e-21	7.77572e-20	1	0	A	109919483	A	A	109919483	3	1	69	1	0	0	0	0	1	0	0	0	3388	912	32	2	27	2	CHRDL1	23	109919483	Missense_Mutation	SNP	C	TCGA-CN-6010-01A-11D-1683-08	7949678	109919483	45351077	187	14153											
SAGE1	55511	broad.mit.edu	37	chrX	134994090	134994090	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataaaatatcaattaatgaaAgaagttcgaaggtttgggca	18	11	9	3	1	1	2	1	1	0	1	2	3	1	2	0	2	0	3	0	2	8	5			TCGA-CN-6010-01A-11D-1683-08	TCGA-CN-6010-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d9693f3-0917-42be-97b8-4dc15cc4d3f6	0aca8971-6bab-418e-a861-c266e085532e	g.chrX:134994090A>G	uc004ezh.2	+	18	2666	c.2499A>G	c.(2497-2499)AAA>AAG	p.K833K	SAGE1_uc010nry.1_Silent_p.K802K|SAGE1_uc011mvv.1_Silent_p.K457K	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	833										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AATTAATGAAAGAAGTTCGAA	0.348													14	61					0	0	0	0	G	134994090	G	G	134994090	2	3	69	1	0	0	0	0	0	0	0	1	13874	69	3	5		5	SAGE1	23	134994090	Silent	SNP	A	TCGA-CN-6010-01A-11D-1683-08	25074607	134994090	20276470	188	14154											
AGRN	375790	broad.mit.edu	37	chr1	981868	981868	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcactgccggcccccccCggcgccctccccctggctcc	2	4	10	25	3	0	0	0	0	0	0	2	0	2	0	9	4	1	2	9	4	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:981868C>T	uc001ack.1	+	18	3053	c.3003C>T	c.(3001-3003)CCC>CCT	p.P1001P		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	1001	Ser/Thr-rich.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CGGCCCCCCCCGGCGCCCTCC	0.701													4	26					0	0	0	0	T	981868	T	T	981868	2	4	70	1	0	0	0	0	0	0	0	1	397	639	23	1		1	AGRN	1	981868	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08		981868	248268753	1	14155											
NBPF1	55672	broad.mit.edu	37	chr1	16893778	16893778	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagataacctgaaggagttGaataacatctatccagtgag	16	9	9	7	0	1	4	0	3	1	1	2	5	2	5	2	1	2	1	2	1	6	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:16893778G>A	uc009vos.1	-	26	3848	c.2960C>T	c.(2959-2961)TCG>TTG	p.S987L	NBPF1_uc009vot.1_Missense_Mutation_p.S370L|NBPF1_uc001ayz.1_Missense_Mutation_p.S370L|NBPF1_uc010oce.1_Missense_Mutation_p.S641L	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	987	NBPF 6.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGAAGGAGTTGAATAACATCT	0.483													16	794					0	0	0	0	A	16893778	A	A	16893778	3	1	70	1	0	0	0	0	1	0	0	0	10245	1294	45	2	709	2	NBPF1	1	16893778	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	15911910	16893778	232356843	2	14156											
UBR4	23352	broad.mit.edu	37	chr1	19473443	19473443	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggtccaaatccttgccctCtttgctagatgtgttgagac	8	13	10	10	0	1	2	0	1	1	2	3	3	3	2	3	1	2	2	3	1	2	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:19473443C>T	uc001bbi.2	-	52	7685	c.7681G>A	c.(7681-7683)GAG>AAG	p.E2561K	UBR4_uc001bbk.1_Missense_Mutation_p.E215K	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2561					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCCTTGCCCTCTTTGCTAGAT	0.527													57	175					0	0	0	0	T	19473443	T	T	19473443	3	4	70	1	0	0	0	0	1	0	0	0	16972	922	32	2	8090	2	UBR4	1	19473443	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2579665	19473443	229777178	3	14157											
RPS6KA1	6195	broad.mit.edu	37	chr1	26898704	26898704	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acggtcccagtgacacaccaGaggaaatcctaacccggatc	13	5	9	14	2	0	2	0	1	0	1	3	4	2	4	4	3	1	0	4	3	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:26898704G>A	uc001bmr.1	+	20	2030	c.1867G>A	c.(1867-1869)GAG>AAG	p.E623K	RPS6KA1_uc010ofe.1_Missense_Mutation_p.E531K|RPS6KA1_uc010off.1_3'UTR|RPS6KA1_uc001bms.1_Missense_Mutation_p.E632K|RPS6KA1_uc009vsl.1_Missense_Mutation_p.E466K	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	623	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		TGACACACCAGAGGAAATCCT	0.567													10	55					0	0	0	0	A	26898704	A	A	26898704	3	1	70	1	0	0	0	0	1	0	0	0	13715	943	33	2	2084	2	RPS6KA1	1	26898704	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	7425261	26898704	222351917	4	14158											
GPATCH3	63906	broad.mit.edu	37	chr1	27220788	27220788	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaggccagagccacccttCtcccacttgagctcaatctc	9	8	6	18	0	3	2	1	1	2	1	5	2	3	2	5	1	2	1	5	1	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:27220788C>T	uc001bne.2	-	3	1019	c.990G>A	c.(988-990)GAG>GAA	p.E330E	GPATCH3_uc009vsp.1_Silent_p.E141E	NM_022078	NP_071361	Q96I76	GPTC3_HUMAN	G patch domain containing 3	330	Glu-rich.					intracellular	nucleic acid binding				0		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		AGCCACCCTTCTCCCACTTGA	0.582													41	95					0	0	0	0	T	27220788	T	T	27220788	2	4	70	1	0	0	0	0	0	0	0	1	6630	912	32	2		2	GPATCH3	1	27220788	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	322084	27220788	222029833	5	14159											
GPATCH3	63906	broad.mit.edu	37	chr1	27223839	27223839	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccttccccacttcttcctCaggctctccacaggggctgg	4	12	8	17	0	3	0	1	0	2	0	7	0	6	0	5	4	0	2	5	4	0	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:27223839C>G	uc001bne.2	-	2	858	c.829G>C	c.(829-831)GAG>CAG	p.E277Q	GPATCH3_uc009vsp.1_Missense_Mutation_p.E88Q	NM_022078	NP_071361	Q96I76	GPTC3_HUMAN	G patch domain containing 3	277	Glu-rich.					intracellular	nucleic acid binding				0		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		ACTTCTTCCTCAGGCTCTCCA	0.542													48	118					0	0	0	0	G	27223839	G	G	27223839	3	3	70	1	0	0	0	0	1	0	0	0	6630	835	29	2	772	2	GPATCH3	1	27223839	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3051	27223839	222026782	6	14160											
EYA3	2140	broad.mit.edu	37	chr1	28374933	28374933	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attcctgcatcttggcttttTtcacctgcaaaaataaatat	12	16	4	9	0	2	0	1	0	1	0	3	0	3	0	2	1	2	3	2	1	5	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:28374933T>C	uc001bpi.1	-	3	203	c.38A>G	c.(37-39)AAA>AGA	p.K13R	EYA3_uc010ofs.1_5'UTR|EYA3_uc010oft.1_Missense_Mutation_p.K13R|EYA3_uc001bpj.2_Missense_Mutation_p.K13R|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3	13					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		CTTGGCTTTTTTCACCTGCAA	0.289													8	25					0	0	0	0	C	28374933	C	C	28374933	3	2	70	1	0	0	0	0	1	0	0	0	5355	1841	64	5	1747	5	EYA3	1	28374933	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	1151094	28374933	220875688	7	14161											
ZMYM1	79830	broad.mit.edu	37	chr1	35579545	35579545	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aacttatctgcagcaaattgGagttgatatggataaaatac	16	12	8	5	0	1	1	0	1	1	0	1	3	1	3	0	2	4	3	0	2	7	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:35579545G>C	uc001bym.2	+	11	2262	c.2114G>C	c.(2113-2115)GGA>GCA	p.G705A	ZMYM1_uc001byn.2_Missense_Mutation_p.G705A|ZMYM1_uc010ohu.1_Missense_Mutation_p.G686A|ZMYM1_uc001byo.2_Missense_Mutation_p.G345A|ZMYM1_uc009vut.2_Missense_Mutation_p.G630A	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	705						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAGCAAATTGGAGTTGATATG	0.353													8	43					0	0	0	0	C	35579545	C	C	35579545	3	2	70	1	0	0	0	0	1	0	0	0	17766	1174	41	2	2148	2	ZMYM1	1	35579545	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	7204612	35579545	213671076	8	14162											
ZMYM1	79830	broad.mit.edu	37	chr1	35579633	35579633	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaatagcagcagaattcaaGaaagaagaaccaagagcttt	21	6	8	6	0	1	5	1	0	0	5	1	5	1	5	1	0	4	3	1	0	9	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:35579633G>C	uc001bym.2	+	11	2350	c.2202G>C	c.(2200-2202)AAG>AAC	p.K734N	ZMYM1_uc001byn.2_Missense_Mutation_p.K734N|ZMYM1_uc010ohu.1_Missense_Mutation_p.K715N|ZMYM1_uc001byo.2_Missense_Mutation_p.K374N|ZMYM1_uc009vut.2_Missense_Mutation_p.K659N	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	734						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAGAATTCAAGAAAGAAGAAC	0.323													12	47					0	0	0	0	C	35579633	C	C	35579633	3	2	70	1	0	0	0	0	1	0	0	0	17766	933	33	2	2236	2	ZMYM1	1	35579633	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	88	35579633	213670988	9	14163											
MFSD2A	84879	broad.mit.edu	37	chr1	40434278	40434278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccgtggctgctcgcagccgGaacgtgtcaagtttacactg	7	9	12	13	4	1	0	1	0	0	0	2	1	1	1	2	2	4	4	2	2	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:40434278G>A	uc001cev.2	+	13	1610	c.1429G>A	c.(1429-1431)GAA>AAA	p.E477K	MFSD2A_uc010ojb.1_Missense_Mutation_p.E425K|MFSD2A_uc001ceu.2_Missense_Mutation_p.E464K|MFSD2A_uc010ojc.1_Missense_Mutation_p.E308K|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cex.2_Missense_Mutation_p.E128K	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	477					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						CTCGCAGCCGGAACGTGTCAA	0.587													45	84					0	0	0	0	A	40434278	A	A	40434278	3	1	70	1	0	0	0	0	1	0	0	0	9583	1175	41	2	1479	2	MFSD2A	1	40434278	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	4854645	40434278	208816343	10	14164											
HIVEP3	59269	broad.mit.edu	37	chr1	41976647	41976647	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggcctcccgggcccctgtCaggtcgctgccacccccgga	3	6	13	19	3	1	0	1	0	0	0	3	1	2	1	7	4	1	1	7	4	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:41976647C>G	uc001cgz.3	-	9	7909	c.6696G>C	c.(6694-6696)CTG>CTC	p.L2232L	HIVEP3_uc001cha.3_Silent_p.L2231L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	2232					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGGCCCCTGTCAGGTCGCTGC	0.692													21	37					0	0	0	0	G	41976647	G	G	41976647	2	3	70	1	0	0	0	0	0	0	0	1	7227	813	29	2		2	HIVEP3	1	41976647	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1542369	41976647	207273974	11	14165											
TOE1	114034	broad.mit.edu	37	chr1	45809091	45809091	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcctgaaatagctgataGagctacctcagaagtgccag	14	7	11	9	0	1	4	1	2	0	2	1	4	1	4	3	1	4	2	3	1	6	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:45809091G>T	uc009vxq.2	+	8	1833	c.1250G>T	c.(1249-1251)AGA>ATA	p.R417I	MUTYH_uc001cno.2_5'Flank|MUTYH_uc001cnk.2_5'Flank|MUTYH_uc010oll.1_5'Flank|MUTYH_uc001cnm.2_5'Flank|MUTYH_uc001cnl.2_5'Flank|MUTYH_uc009vxp.2_5'Flank|MUTYH_uc001cnn.2_5'Flank|TOE1_uc001cnq.3_RNA|TOE1_uc010olm.1_Missense_Mutation_p.R337I|TOE1_uc001cnr.3_RNA	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	417						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)					ATAGCTGATAGAGCTACCTCA	0.517													40	35					5.71845e-15	6.18042e-15	1	0	T	45809091	T	T	45809091	3	4	70	1	0	0	0	0	1	0	0	0	16415	942	33	2	1280	2	TOE1	1	45809091	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3832444	45809091	203441530	12	14166											
CYP4A11	1579	broad.mit.edu	37	chr1	47401219	47401219	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacctggatgctgccctgaTggctgaaggcacacttcatg	8	9	11	13	0	1	2	1	2	0	0	1	3	1	3	3	3	2	3	3	3	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:47401219T>G	uc001cqp.3	-	5	662	c.611A>C	c.(610-612)CAT>CCT	p.H204P	CYP4A11_uc001cqq.2_Missense_Mutation_p.H204P|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	204					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GCTGCCCTGATGGCTGAAGGC	0.572													17	59					0	0	0	0	G	47401219	G	G	47401219	3	3	70	1	0	0	0	0	1	0	0	0	4200	1464	51	5	980	5	CYP4A11	1	47401219	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	1592128	47401219	201849402	13	14167											
FOXD2	2306	broad.mit.edu	37	chr1	47904276	47904276	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcgagatctgcgagttcAtcagcggccgcttcccctac	7	9	11	14	4	3	2	2	1	1	1	4	4	4	2	3	1	4	2	3	1	1	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:47904276A>G	uc001crm.2	+	1	2588	c.469A>G	c.(469-471)ATC>GTC	p.I157V		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	157	Fork-head.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		CTGCGAGTTCATCAGCGGCCG	0.617													21	45					0	0	0	0	G	47904276	G	G	47904276	3	3	70	1	0	0	0	0	1	0	0	0	6029	217	8	5	471	5	FOXD2	1	47904276	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08	503057	47904276	201346345	14	14168											
ZFYVE9	9372	broad.mit.edu	37	chr1	52810452	52810452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaacaggtgtttttcctaGaaaacgatgaccagcacaat	14	9	10	8	1	0	2	0	1	0	1	1	4	1	3	2	2	3	2	2	2	5	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:52810452G>A	uc001cto.2	+	18	4124	c.3952G>A	c.(3952-3954)GAA>AAA	p.E1318K	ZFYVE9_uc001ctp.2_Missense_Mutation_p.E1259K	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	1318					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						GTTTTTCCTAGAAAACGATGA	0.433													20	49					0	0	0	0	A	52810452	A	A	52810452	3	1	70	1	0	0	0	0	1	0	0	0	17738	943	33	2	4025	2	ZFYVE9	1	52810452	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	4906176	52810452	196440169	15	14169											
ZYG11B	79699	broad.mit.edu	37	chr1	53262010	53262010	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agtggctttgcaaccatgagGatcaaaacatgcaaaggatg	15	8	11	7	0	1	1	1	1	0	0	1	3	1	3	1	3	4	3	1	3	4	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:53262010G>C	uc001cuj.2	+	7	1576	c.1381G>C	c.(1381-1383)GAT>CAT	p.D461H	ZYG11B_uc009vzg.2_RNA|ZYG11B_uc010onj.1_Missense_Mutation_p.D452H|ZYG11B_uc009vzh.2_5'Flank	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	461							protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CAACCATGAGGATCAAAACAT	0.433													11	35					0	0	0	0	C	53262010	C	C	53262010	3	2	70	1	0	0	0	0	1	0	0	0	18320	1174	41	2	1407	2	ZYG11B	1	53262010	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	451558	53262010	195988611	16	14170											
CYP2J2	1573	broad.mit.edu	37	chr1	60381745	60381746	+	Frame_Shift_Ins	INS	-	A	A																															atgtcaccaagctccaagctINSaaaaaggttcccatatttct																										TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:60381745_60381746insA	uc001czq.2	-	2	242_243	c.237_238insT	c.(235-240)TTTAGCfs	p.F79fs		NM_000775	NP_000766	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J,	79_80					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			ovary(1)	1	all_cancers(7;0.000396)					AGCTCCAAGCTAAAAAGGTTCC	0.411													---	---	---								A	60381746	A	A	60381745	7	5	70	1	0	1	1	0	0	0	0	0	4189	1522	53	0	1302	0	CYP2J2	1	60381745	Frame_Shift_Ins	INS	-	TCGA-CN-6011-01A-11D-1683-08	7119735	60381745	188868876	17	14171											
PTGER3	5733	broad.mit.edu	37	chr1	71478156	71478156	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctgattgaagatcattttCaacatcattatctaagaaaa	16	14	5	6	0	5	4	3	2	2	2	5	4	5	4	0	0	1	0	0	0	6	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:71478156C>G	uc001dfg.1	-	2	1140	c.909G>C	c.(907-909)TTG>TTC	p.L303F	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Missense_Mutation_p.L303F|PTGER3_uc001dfl.1_Missense_Mutation_p.L303F|PTGER3_uc009wbm.1_Missense_Mutation_p.L303F|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Missense_Mutation_p.L303F|PTGER3_uc009wbn.1_Missense_Mutation_p.L303F|PTGER3_uc009wbo.2_Missense_Mutation_p.L303F|PTGER3_uc001dfo.2_Missense_Mutation_p.L303F|PTGER3_uc001dfp.1_Missense_Mutation_p.L303F|PTGER3_uc001dfq.2_Missense_Mutation_p.L303F	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	303	Helical; Name=6; (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)	AGATCATTTTCAACATCATTA	0.289													14	35					0	0	0	0	G	71478156	G	G	71478156	3	3	70	1	0	0	0	0	1	0	0	0	12807	825	29	2	578	2	PTGER3	1	71478156	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	11096411	71478156	177772465	18	14172											
CRYZ	1429	broad.mit.edu	37	chr1	75188946	75188946	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaccacatgcatggaccttGattagaacctgcaatgacaa	15	8	7	11	0	0	3	0	2	0	1	0	4	0	4	3	1	3	2	3	1	4	2	rs146208357	byFrequency	TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:75188946G>A	uc001dgk.2	-	4	625	c.120C>T	c.(118-120)ATC>ATT	p.I40I	CRYZ_uc001dgj.2_Silent_p.I40I|CRYZ_uc001dgl.2_Silent_p.I40I|CRYZ_uc001dgm.2_5'UTR	NM_001130042	NP_001123514	Q08257	QOR_HUMAN	crystallin, zeta isoform a	40					protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)	CATGGACCTTGATTAGAACCT	0.328													27	67					0	0	0	0	A	75188946	A	A	75188946	2	1	70	1	0	0	0	0	0	0	0	1	3937	1280	45	2		2	CRYZ	1	75188946	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3710790	75188946	174061675	19	14173											
MCOLN2	255231	broad.mit.edu	37	chr1	85403762	85403762	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagagatcatagtttgtgaGattctaaggaatgaaaaaaa	18	10	10	3	0	2	3	1	2	1	2	2	6	2	4	0	1	0	2	0	1	6	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:85403762G>C	uc001dkm.2	-	10	1355	c.1114C>G	c.(1114-1116)CTC>GTC	p.L372V	MCOLN2_uc001dkn.2_RNA	NM_153259	NP_694991	Q8IZK6	MCLN2_HUMAN	mucolipin 2	372						integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		TAGTTTGTGAGATTCTAAGGA	0.338													23	26					0	0	0	0	C	85403762	C	C	85403762	3	2	70	1	0	0	0	0	1	0	0	0	9449	942	33	2	606	2	MCOLN2	1	85403762	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	10214816	85403762	163846859	20	14174											
HFM1	164045	broad.mit.edu	37	chr1	91813030	91813030	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttgttcaatccagatgcaAaacctgcatgtcatgaaaaa	15	11	6	9	0	2	2	2	1	0	1	3	2	3	2	2	0	3	3	2	0	5	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:91813030A>G	uc001doa.3	-	19	2310	c.2210T>C	c.(2209-2211)TTT>TCT	p.F737S	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.F416S|HFM1_uc001dob.3_5'UTR|HFM1_uc010osv.1_Missense_Mutation_p.F421S	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	737							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TCCAGATGCAAAACCTGCATG	0.303													8	36					0	0	0	0	G	91813030	G	G	91813030	3	3	70	1	0	0	0	0	1	0	0	0	7122	14	1	5	2181	5	HFM1	1	91813030	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08	6409268	91813030	157437591	21	14175											
EPHX4	253152	broad.mit.edu	37	chr1	92495681	92495681	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccccgcctgatgctcacgctCcggtccctgctcttctggtc	2	11	9	19	3	3	1	1	1	2	0	6	1	5	1	5	2	2	3	5	2	0	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:92495681C>T	uc001don.2	+	1	149	c.45C>T	c.(43-45)CTC>CTT	p.L15L		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	15						integral to membrane	hydrolase activity			central_nervous_system(1)	1						TGCTCACGCTCCGGTCCCTGC	0.701													7	18					0	0	0	0	T	92495681	T	T	92495681	2	4	70	1	0	0	0	0	0	0	0	1	5206	842	30	2		2	EPHX4	1	92495681	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	682651	92495681	156754940	22	14176											
ARHGAP29	9411	broad.mit.edu	37	chr1	94643210	94643210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctaacgcattttgcttgcGttctgattcctcaaatgatg	8	16	7	10	2	2	2	1	2	1	0	4	2	4	2	2	0	3	3	2	0	2	6	rs141790636		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:94643210G>A	uc001dqj.3	-	22	3232	c.2863C>T	c.(2863-2865)CGC>TGC	p.R955C	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Missense_Mutation_p.R521C	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	955					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTTTGCTTGCGTTCTGATTCC	0.343													19	56					0	0	0	0	A	94643210	A	A	94643210	3	1	70	1	0	0	0	0	1	0	0	0	878	1145	40	1	930	1	ARHGAP29	1	94643210	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2147529	94643210	154607411	23	14177											
C1orf161	126868	broad.mit.edu	37	chr1	116666715	116666715	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagtcagttcctcgtcaCagtcccaataaaaggcctgg	10	9	8	14	1	2	0	2	0	0	0	6	0	5	0	4	2	0	1	4	2	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:116666715C>A	uc001egc.1	+	4	483	c.218C>A	c.(217-219)ACA>AAA	p.T73K		NM_152367	NP_689580	Q8N8X9	MB213_HUMAN	hypothetical protein LOC126868	73											0	Lung SC(450;0.184)	all_cancers(81;0.00142)|all_lung(203;0.000139)|all_epithelial(167;0.000401)|Lung NSC(69;0.000705)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTCCTCGTCACAGTCCCAATA	0.577													24	65					2.44723e-14	2.63343e-14	1	0	A	116666715	A	A	116666715	3	1	70	1	0	0	0	0	1	0	0	0	2018	478	17	4	228	4	C1orf161	1	116666715	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	22023505	116666715	132583906	24	14178											
HAO2	51179	broad.mit.edu	37	chr1	119927521	119927521	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctatgtgcatccagacctgCagctgaacaaacagttgatc	12	10	8	11	0	1	3	0	2	1	1	3	3	2	3	2	0	5	4	2	0	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:119927521C>T	uc001ehq.1	+	5	758	c.406C>T	c.(406-408)CAG>TAG	p.Q136*	HAO2_uc001ehr.1_Nonsense_Mutation_p.Q136*	NM_001005783	NP_001005783	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2	136	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			ovary(2)|skin(2)	4	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		TCCAGACCTGCAGCTGAACAA	0.478													23	59					0	0	0	0	T	119927521	T	T	119927521	4	4	70	1	0	0	0	0	0	1	0	0	6991	711	25	4	416	4	HAO2	1	119927521	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3260806	119927521	129323100	25	14179											
VPS45	11311	broad.mit.edu	37	chr1	150054908	150054908	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcagtgaacggaatctgctgGaggtttcagaggttgagcaa	11	10	14	6	1	3	3	2	2	1	1	3	5	3	5	0	4	3	4	0	4	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:150054908G>A	uc001etp.2	+	10	1618	c.1045G>A	c.(1045-1047)GAG>AAG	p.E349K	VPS45_uc010pbp.1_RNA|VPS45_uc010pbq.1_Missense_Mutation_p.E313K|VPS45_uc010pbs.1_Missense_Mutation_p.E244K|VPS45_uc001etq.2_Missense_Mutation_p.E169K|VPS45_uc009wlm.1_Missense_Mutation_p.E325K	NM_007259	NP_009190	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45A	349					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				central_nervous_system(1)|skin(1)	2	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAATCTGCTGGAGGTTTCAGA	0.388													18	34					0	0	0	0	A	150054908	A	A	150054908	3	1	70	1	0	0	0	0	1	0	0	0	17279	1175	41	2	1083	2	VPS45	1	150054908	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	30127387	150054908	99195713	26	14180											
SETDB1	9869	broad.mit.edu	37	chr1	150915471	150915471	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaaatacaaagatgggaatCaggtctggctctatgctggc	12	9	11	9	0	3	1	1	0	2	1	3	2	3	2	1	4	2	2	1	4	5	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:150915471C>G	uc001evu.2	+	7	1007	c.817C>G	c.(817-819)CAG>GAG	p.Q273E	SETDB1_uc009wmf.2_Missense_Mutation_p.Q273E|SETDB1_uc001evv.2_Missense_Mutation_p.Q273E|SETDB1_uc001evw.3_Missense_Mutation_p.Q273E|SETDB1_uc009wmg.1_Missense_Mutation_p.Q273E	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	273	Tudor 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGATGGGAATCAGGTCTGGCT	0.517													24	75					0	0	0	0	G	150915471	G	G	150915471	3	3	70	1	0	0	0	0	1	0	0	0	14203	827	29	2	839	2	SETDB1	1	150915471	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	860563	150915471	98335150	27	14181											
CGN	57530	broad.mit.edu	37	chr1	151505015	151505015	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggccagtgaggctgagaaGacctctggaggactgagccg	9	6	17	9	1	1	4	0	3	1	2	1	7	1	6	3	4	1	1	3	4	1	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:151505015G>C	uc009wmw.2	+	14	2853	c.2709G>C	c.(2707-2709)AAG>AAC	p.K903N	CGN_uc010pde.1_5'Flank	NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	897	Potential.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGGCTGAGAAGACCTCTGGAG	0.502													7	36					0	0	0	0	C	151505015	C	C	151505015	3	2	70	1	0	0	0	0	1	0	0	0	3318	933	33	2	2759	2	CGN	1	151505015	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	589544	151505015	97745606	28	14182											
FLG	2312	broad.mit.edu	37	chr1	152280813	152280813	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgcacttctggatcctgaCtgcccacgggaggcatcaga	8	9	11	13	1	2	2	1	1	1	1	3	4	3	4	2	3	2	2	2	3	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:152280813C>G	uc001ezu.1	-	3	6585	c.6549G>C	c.(6547-6549)CAG>CAC	p.Q2183H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2183	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGATCCTGACTGCCCACGGG	0.537									Ichthyosis				5	361					0	0	0	0	G	152280813	G	G	152280813	3	3	70	1	0	0	0	0	1	0	0	0	5954	564	20	4	5640	4	FLG	1	152280813	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	775798	152280813	96969808	29	14183											
FLG2	388698	broad.mit.edu	37	chr1	152329438	152329438	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccacatgcatgacttcgcCtcccactgtctcctgaacct	9	10	5	17	1	1	2	0	2	1	0	4	2	2	2	5	0	3	1	5	0	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:152329438C>T	uc001ezw.3	-	3	897	c.824G>A	c.(823-825)AGG>AAG	p.R275K	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	275	Ser-rich.|Filaggrin 1.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGACTTCGCCTCCCACTGTC	0.448													93	26					0	0	0	0	T	152329438	T	T	152329438	3	4	70	1	0	0	0	0	1	0	0	0	5955	681	24	4	6355	4	FLG2	1	152329438	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	48625	152329438	96921183	30	14184											
CRNN	49860	broad.mit.edu	37	chr1	152382205	152382205	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctggtccagcctgaggatCactgtctcccttgagtggtc	5	11	11	14	0	2	2	1	2	1	0	5	3	3	3	4	3	1	0	4	3	0	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:152382205C>G	uc001ezx.2	-	3	1427	c.1353G>C	c.(1351-1353)GTG>GTC	p.V451V		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	451					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGAGGATCACTGTCTCCC	0.577													16	56					0	0	0	0	G	152382205	G	G	152382205	2	3	70	1	0	0	0	0	0	0	0	1	3907	813	29	2		2	CRNN	1	152382205	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	52767	152382205	96868416	31	14185											
S100A7A	338324	broad.mit.edu	37	chr1	153391671	153391671	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctttgagaaaaaggacaaGaatgaggataagaagattga	19	8	12	2	0	1	6	0	3	1	4	1	9	1	8	0	2	0	0	0	2	6	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:153391671G>C	uc001fbt.1	+	3	249	c.192G>C	c.(190-192)AAG>AAC	p.K64N		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	64	2; high affinity (Potential).|EF-hand 2.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAAAGGACAAGAATGAGGATA	0.423													24	60					0	0	0	0	C	153391671	C	C	153391671	3	2	70	1	0	0	0	0	1	0	0	0	13849	933	33	2	198	2	S100A7A	1	153391671	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1009466	153391671	95858950	32	14186											
KCNN3	3782	broad.mit.edu	37	chr1	154841649	154841649	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccagcttatagccaatgttTtggtttttccgcttgttggc	5	17	9	10	1	0	0	0	0	0	0	1	0	1	0	3	2	2	5	3	2	3	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:154841649T>C	uc001ffp.2	-	1	1106	c.792A>G	c.(790-792)CAA>CAG	p.Q264Q	KCNN3_uc009wox.1_Silent_p.Q264Q	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	269						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			AGCCAATGTTTTGGTTTTTCC	0.512													71	21					0	0	0	0	C	154841649	C	C	154841649	2	2	70	1	0	0	0	0	0	0	0	1	8119	1838	64	5		5	KCNN3	1	154841649	Silent	SNP	T	TCGA-CN-6011-01A-11D-1683-08	1449978	154841649	94408972	33	14187											
FCER1A	2205	broad.mit.edu	37	chr1	159275900	159275900	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attataaggatggtgaagctCtcaagtactggtatgagaac	14	11	11	5	0	1	2	1	2	1	1	2	4	1	3	0	3	3	3	0	3	7	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:159275900C>T	uc001ftq.2	+	5	553	c.454C>T	c.(454-456)CTC>TTC	p.L152F		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	152	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	TGGTGAAGCTCTCAAGTACTG	0.498													26	57					0	0	0	0	T	159275900	T	T	159275900	3	4	70	1	0	0	0	0	1	0	0	0	5806	913	32	2	468	2	FCER1A	1	159275900	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	4434251	159275900	89974721	34	14188											
IGSF9	57549	broad.mit.edu	37	chr1	159906249	159906249	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgctggaggcttggcaggTgtagaccccagagctgcctc	7	8	15	11	0	0	2	0	0	0	2	1	3	0	3	3	4	3	5	3	4	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:159906249T>G	uc001fur.2	-	6	811	c.613A>C	c.(613-615)ACC>CCC	p.T205P	IGSF9_uc001fuq.2_Missense_Mutation_p.T205P	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	205	Ig-like 2.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GCTTGGCAGGTGTAGACCCCA	0.657											OREG0013921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	34					0	0	0	0	G	159906249	G	G	159906249	3	3	70	1	0	0	0	0	1	0	0	0	7644	1696	59	5	2990	5	IGSF9	1	159906249	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	630349	159906249	89344372	35	14189											
TDRD5	163589	broad.mit.edu	37	chr1	179603612	179603612	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagtcagataagaaaataGaagccaaagcttgtgtctcc	15	10	8	8	0	3	3	2	0	1	3	4	3	3	3	2	0	2	1	2	0	6	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:179603612G>T	uc001gnf.1	+	8	1397	c.1147G>T	c.(1147-1149)GAA>TAA	p.E383*	TDRD5_uc010pnp.1_Nonsense_Mutation_p.E383*|TDRD5_uc001gnh.1_5'UTR	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	383	Lotus/OST-HTH 3.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						TAAGAAAATAGAAGCCAAAGC	0.383													22	72					6.32553e-13	6.77735e-13	1	0	T	179603612	T	T	179603612	4	4	70	1	0	0	0	0	0	1	0	0	15799	943	33	2	1173	2	TDRD5	1	179603612	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	19697363	179603612	69647009	36	14190											
KDM5B	10765	broad.mit.edu	37	chr1	202702867	202702867	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccctgcagagttcacattGaatcataggggcagctgggg	10	9	13	9	0	2	2	2	1	0	1	3	2	3	2	1	4	2	4	1	4	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:202702867G>A	uc001gyf.2	-	23	3687	c.3571C>T	c.(3571-3573)CAA>TAA	p.Q1191*	KDM5B_uc009xag.2_Nonsense_Mutation_p.Q1227*|KDM5B_uc001gyg.1_Nonsense_Mutation_p.Q1033*	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1191	PHD-type 2.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						AGTTCACATTGAATCATAGGG	0.517													21	47					0	0	0	0	A	202702867	A	A	202702867	4	1	70	1	0	0	0	0	0	1	0	0	8173	1299	45	2	1083	2	KDM5B	1	202702867	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	23099255	202702867	46547754	37	14191											
KDM5B	10765	broad.mit.edu	37	chr1	202731854	202731854	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggcttttttagatcgactCttgggcttttccttctcatt	4	20	8	9	1	2	1	1	0	2	1	5	2	3	1	1	2	0	2	1	2	1	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:202731854C>G	uc001gyf.2	-	7	1007	c.891G>C	c.(889-891)AAG>AAC	p.K297N	KDM5B_uc009xag.2_Missense_Mutation_p.K333N|KDM5B_uc001gyg.1_Missense_Mutation_p.K139N	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	297					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						TAGATCGACTCTTGGGCTTTT	0.294													34	154					0	0	0	0	G	202731854	G	G	202731854	3	3	70	1	0	0	0	0	1	0	0	0	8173	912	32	2	3827	2	KDM5B	1	202731854	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	28987	202731854	46518767	38	14192											
AVPR1B	553	broad.mit.edu	37	chr1	206225115	206225115	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacagcctcatctgccatgaGatctgtaaaaacctaaaagt	15	10	6	10	0	3	1	1	1	2	1	3	2	3	1	3	0	4	1	3	0	6	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:206225115G>C	uc001hds.2	+	1	833	c.675G>C	c.(673-675)GAG>GAC	p.E225D		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	225	Cytoplasmic (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	TCTGCCATGAGATCTGTAAAA	0.607													23	79					0	0	0	0	C	206225115	C	C	206225115	3	2	70	1	0	0	0	0	1	0	0	0	1234	933	33	2	677	2	AVPR1B	1	206225115	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3493261	206225115	43025506	39	14193											
KCNH1	3756	broad.mit.edu	37	chr1	210857055	210857055	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accttgttccagtcctcactCttcccgcaagcatctttgaa	8	13	5	15	1	3	1	1	1	2	0	6	1	6	1	4	0	1	3	4	0	2	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:210857055C>G	uc001hib.2	-	11	2708	c.2538G>C	c.(2536-2538)AAG>AAC	p.K846N	KCNH1_uc001hic.2_Missense_Mutation_p.K819N	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	846	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AGTCCTCACTCTTCCCGCAAG	0.612													18	62					0	0	0	0	G	210857055	G	G	210857055	3	3	70	1	0	0	0	0	1	0	0	0	8070	912	32	2	435	2	KCNH1	1	210857055	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	4631940	210857055	38393566	40	14194											
C1orf227	149643	broad.mit.edu	37	chr1	213009314	213009314	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggctctttggttgtggtatCagtaaaggactgataggcat	10	13	13	5	0	2	1	1	1	1	0	2	2	2	2	0	5	0	5	0	5	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:213009314C>G	uc001hjq.2	-	2	286	c.178G>C	c.(178-180)GAT>CAT	p.D60H		NM_001024601	NP_001019772	Q537H7	CA227_HUMAN	hypothetical protein LOC149643	60											0						GTTGTGGTATCAGTAAAGGAC	0.483													30	91					0	0	0	0	G	213009314	G	G	213009314	3	3	70	1	0	0	0	0	1	0	0	0	2043	826	29	2	126	2	C1orf227	1	213009314	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2152259	213009314	36241307	41	14195											
CENPF	1063	broad.mit.edu	37	chr1	214816003	214816003	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgcagacctatgttgactCattaaaggccgaaaatttgg	12	11	10	8	1	1	2	1	1	0	1	1	3	1	2	2	2	1	3	2	2	5	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:214816003C>T	uc001hkm.2	+	12	4496	c.4322C>T	c.(4321-4323)TCA>TTA	p.S1441L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1537	1-2.|2 X 96 AA approximate tandem repeats.		Missing.		cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TATGTTGACTCATTAAAGGCC	0.423													12	38					0	0	0	0	T	214816003	T	T	214816003	3	4	70	1	0	0	0	0	1	0	0	0	3246	838	29	2	4364	2	CENPF	1	214816003	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1806689	214816003	34434618	42	14196											
USH2A	7399	broad.mit.edu	37	chr1	216040365	216040365	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacttggtttagcccacctCacgtcgatggctgtgtggtt	5	15	11	10	2	1	0	1	0	0	0	2	1	1	0	2	3	2	3	2	3	2	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:216040365C>G	uc001hku.1	-	44	9216	c.8829G>C	c.(8827-8829)GTG>GTC	p.V2943V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2943	Fibronectin type-III 16.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAGCCCACCTCACGTCGATGG	0.448										HNSCC(13;0.011)			18	47					0	0	0	0	G	216040365	G	G	216040365	2	3	70	1	0	0	0	0	0	0	0	1	17104	813	29	2		2	USH2A	1	216040365	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1224362	216040365	33210256	43	14197											
OBSCN	84033	broad.mit.edu	37	chr1	228509435	228509435	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcactggcctggaccgtgctGatgctggctgctacacctgt	5	11	12	13	1	1	1	1	1	0	0	1	2	1	2	3	3	4	4	3	3	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:228509435G>A	uc009xez.1	+	55	14937	c.14893G>A	c.(14893-14895)GAT>AAT	p.D4965N	OBSCN_uc001hsn.2_Missense_Mutation_p.D4965N	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4965	Ig-like 48.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGACCGTGCTGATGCTGGCTG	0.602													22	76					0	0	0	0	A	228509435	A	A	228509435	3	1	70	1	0	0	0	0	1	0	0	0	10866	1290	45	2	15107	2	OBSCN	1	228509435	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	12469070	228509435	20741186	44	14198											
RYR2	6262	broad.mit.edu	37	chr1	237947379	237947379	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacttttctggaattagcaGagagcgtcctgaattatttc	11	14	9	7	1	1	3	0	1	1	2	3	5	2	4	1	1	2	1	1	1	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:237947379G>A	uc001hyl.1	+	90	12487	c.12367G>A	c.(12367-12369)GAG>AAG	p.E4123K	RYR2_uc010pya.1_Missense_Mutation_p.E538K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4123					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGAATTAGCAGAGAGCGTCCT	0.512													19	24					0	0	0	0	A	237947379	A	A	237947379	3	1	70	1	0	0	0	0	1	0	0	0	13834	943	33	2	12725	2	RYR2	1	237947379	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	9437944	237947379	11303242	45	14199											
CEP170	9859	broad.mit.edu	37	chr1	243354558	243354558	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tggtctctaatagttaccttCcctggggtactgtcatcaaa	9	14	8	10	0	3	0	2	0	1	0	5	0	4	0	2	3	2	2	2	3	5	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:243354558C>G	uc001hzs.2	-	8	1278	c.870G>C	c.(868-870)GGG>GGC	p.G290G	CEP170_uc001hzt.2_Silent_p.G290G|CEP170_uc001hzu.2_Silent_p.G290G	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	290						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TAGTTACCTTCCCTGGGGTAC	0.438													4	16					0	0	0	0	G	243354558	G	G	243354558	2	3	70	1	0	0	0	0	0	0	0	1	3265	842	30	2		2	CEP170	1	243354558	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	5407179	243354558	5896063	46	14200											
PGBD2	267002	broad.mit.edu	37	chr1	249211397	249211397	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gatgttctgggaaacctctcCcgattcacatcatcatcttg	9	13	7	12	1	6	0	3	0	3	0	7	3	6	1	2	1	1	1	2	1	1	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:249211397C>T	uc001ifh.2	+	3	761	c.614C>T	c.(613-615)CCC>CTC	p.P205L	PGBD2_uc001ifg.2_Intron|PGBD2_uc009xhd.2_Missense_Mutation_p.P202L	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	205										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GAAACCTCTCCCGATTCACAT	0.398													34	120					0	0	0	0	T	249211397	T	T	249211397	3	4	70	1	0	0	0	0	1	0	0	0	11836	623	22	4	620	4	PGBD2	1	249211397	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	5856839	249211397	39224	47	14201											
RNASEH1	246243	broad.mit.edu	37	chr2	3599789	3599789	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccggctccacgctcggcttCatgtgctttgcatacggctc	4	11	11	15	4	1	0	1	0	0	0	4	0	2	0	2	3	3	6	2	3	1	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:3599789C>T	uc002qxt.2	-	3	444	c.354G>A	c.(352-354)ATG>ATA	p.M118I	RNASEH1_uc002qxs.2_Missense_Mutation_p.M1I	NM_002936	NP_002927	O60930	RNH1_HUMAN	ribonuclease H1	118					RNA catabolic process	cytoplasm	magnesium ion binding|ribonuclease H activity|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0713)|Epithelial(75;0.167)|all cancers(51;0.22)		CGCTCGGCTTCATGTGCTTTG	0.517													15	38					0	0	0	0	T	3599789	T	T	3599789	3	4	70	1	0	0	0	0	1	0	0	0	13476	826	29	2	530	2	RNASEH1	2	3599789	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08		3599789	239599584	48	14202											
GRHL1	29841	broad.mit.edu	37	chr2	10136059	10136059	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagatgactttgctgtccctCcttctaccaagctggcccgg	7	11	9	14	1	1	2	0	1	1	1	3	2	3	2	4	2	3	2	4	2	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:10136059C>T	uc002raa.2	+	13	1723	c.1552C>T	c.(1552-1554)CCT>TCT	p.P518S	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.P329S|GRHL1_uc010yjb.1_Missense_Mutation_p.P367S	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	518					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TGCTGTCCCTCCTTCTACCAA	0.458													42	92					0	0	0	0	T	10136059	T	T	10136059	3	4	70	1	0	0	0	0	1	0	0	0	6802	855	30	2	1602	2	GRHL1	2	10136059	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	6536270	10136059	233063314	49	14203											
MFSD2B	388931	broad.mit.edu	37	chr2	24247130	24247130	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggacgcctccagccggctGagccttcggaggtaagcccc	6	5	14	16	4	0	1	0	1	0	0	2	3	1	3	6	4	3	2	6	4	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:24247130G>T	uc002reo.1	+	13	1493	c.1479G>T	c.(1477-1479)CTG>CTT	p.L493L		NM_001080473	NP_001073942	A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing	493					transport	integral to membrane				ovary(2)	2						CCAGCCGGCTGAGCCTTCGGA	0.647													7	1					0.000157383	0.000162302	1	0	T	24247130	T	T	24247130	2	4	70	1	0	0	0	0	0	0	0	1	9584	1277	45	2		2	MFSD2B	2	24247130	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	14111071	24247130	218952243	50	14204											
SLC30A6	55676	broad.mit.edu	37	chr2	32445600	32445600	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtgaacccagttattcttCtaaacacacaaacaaggcct	15	10	5	11	0	2	1	0	1	2	0	2	1	2	1	2	1	3	1	2	1	6	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:32445600C>G	uc002roe.1	+	14	1241	c.1204C>G	c.(1204-1206)CTA>GTA	p.L402V	SLC30A6_uc002rof.1_Missense_Mutation_p.L442V|SLC30A6_uc010ymw.1_Missense_Mutation_p.L373V|SLC30A6_uc010ezr.1_Missense_Mutation_p.L379V|SLC30A6_uc002rog.1_Missense_Mutation_p.L205V|SLC30A6_uc010ezs.1_Missense_Mutation_p.L328V|SLC30A6_uc002roh.1_Missense_Mutation_p.L205V	NM_017964	NP_060434	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter),	402	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AGTTATTCTTCTAAACACACA	0.418													82	24					0	0	0	0	G	32445600	G	G	32445600	3	3	70	1	0	0	0	0	1	0	0	0	14623	912	32	2	1258	2	SLC30A6	2	32445600	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	8198470	32445600	210753773	51	14205											
BIRC6	57448	broad.mit.edu	37	chr2	32688441	32688441	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagcagcttttgaagcttCagcaacaggttggagactat	12	10	11	8	0	1	2	1	1	0	1	1	3	1	2	0	2	6	6	0	2	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:32688441C>T	uc010ezu.2	+	24	5067	c.4933C>T	c.(4933-4935)CAG>TAG	p.Q1645*		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1645					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTTGAAGCTTCAGCAACAGGT	0.423													5	18					0	0	0	0	T	32688441	T	T	32688441	4	4	70	1	0	0	0	0	0	1	0	0	1441	827	29	2	5027	2	BIRC6	2	32688441	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	242841	32688441	210510932	52	14206											
PREPL	9581	broad.mit.edu	37	chr2	44565513	44565513	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagagaccgaactgaatcatCagccagaccaatcacattaa	17	7	6	11	1	3	3	3	1	0	2	3	5	3	3	3	0	2	0	3	0	5	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:44565513C>T	uc002ruf.2	-	7	1167	c.1132G>A	c.(1132-1134)GAT>AAT	p.D378N	PREPL_uc002rug.2_Missense_Mutation_p.D378N|PREPL_uc002ruh.2_Intron|PREPL_uc010fax.2_Missense_Mutation_p.D378N|PREPL_uc002rui.3_Missense_Mutation_p.D289N|PREPL_uc002ruj.1_Missense_Mutation_p.D289N|PREPL_uc002ruk.1_Missense_Mutation_p.D378N	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	378					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ACTGAATCATCAGCCAGACCA	0.328													19	9					0	0	0	0	T	44565513	T	T	44565513	3	4	70	1	0	0	0	0	1	0	0	0	12537	826	29	2	1083	2	PREPL	2	44565513	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	11877072	44565513	198633860	53	14207											
HK2	3099	broad.mit.edu	37	chr2	75115157	75115157	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaagacaaggggcatctttGaaaccaagttcttgtctcag	12	11	9	9	0	4	2	2	1	3	1	5	2	4	2	1	2	1	2	1	2	4	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:75115157G>C	uc002snd.2	+	16	4273	c.2347G>C	c.(2347-2349)GAA>CAA	p.E783Q		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	783	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GGGCATCTTTGAAACCAAGTT	0.512													17	58					0	0	0	0	C	75115157	C	C	75115157	3	2	70	1	0	0	0	0	1	0	0	0	7230	1291	45	2	2409	2	HK2	2	75115157	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	30549644	75115157	168084216	54	14208											
NCK2	8440	broad.mit.edu	37	chr2	106498397	106498397	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctcgtccagcgggcgcttCgcgggcagagagtggtacta	6	7	15	13	5	0	1	0	0	0	1	3	2	1	1	2	3	2	3	2	3	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:106498397C>T	uc002tdg.2	+	4	1282	c.840C>T	c.(838-840)TTC>TTT	p.F280F	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Silent_p.F280F	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	280					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GCGGGCGCTTCGCGGGCAGAG	0.672													10	38					0	0	0	0	T	106498397	T	T	106498397	2	4	70	1	0	0	0	0	0	0	0	1	10274	883	31	1		1	NCK2	2	106498397	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	31383240	106498397	136700976	55	14209											
MYO7B	4648	broad.mit.edu	37	chr2	128354096	128354096	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgctagacagagcggcgctCagcatccagaaagtccttcg	10	7	12	12	3	1	3	1	0	0	3	4	3	3	3	2	1	3	3	2	1	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:128354096C>T	uc002top.2	+	19	2357	c.2304C>T	c.(2302-2304)CTC>CTT	p.L768L		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	768	IQ 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GAGCGGCGCTCAGCATCCAGA	0.627													3	12					0	0	0	0	T	128354096	T	T	128354096	2	4	70	1	0	0	0	0	0	0	0	1	10136	813	29	2		2	MYO7B	2	128354096	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	21855699	128354096	114845277	56	14210											
YSK4	80122	broad.mit.edu	37	chr2	135738606	135738606	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gactcattgatgacttctggGgccatccaatatggagtccc	9	11	10	11	0	2	2	1	2	1	0	4	4	4	3	3	3	0	0	3	3	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:135738606G>T	uc002tue.1	-	9	3736	c.3705C>A	c.(3703-3705)GCC>GCA	p.A1235A	YSK4_uc002tuf.1_Silent_p.A417A|YSK4_uc010fnc.1_Silent_p.A369A|YSK4_uc010fnd.1_Silent_p.A1122A|YSK4_uc010zbg.1_Silent_p.A367A|YSK4_uc002tuh.3_Silent_p.A963A|YSK4_uc002tui.3_3'UTR	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1235	Protein kinase.			A -> V (in Ref. 2; BAB15538).			ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TGACTTCTGGGGCCATCCAAT	0.502													13	37					4.3838e-07	4.60718e-07	1	0	T	135738606	T	T	135738606	2	4	70	1	0	0	0	0	0	0	0	1	17563	1219	43	4		4	YSK4	2	135738606	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	7384510	135738606	107460767	57	14211											
LRP1B	53353	broad.mit.edu	37	chr2	141771238	141771238	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaaaatggaaccattcataTaatcagtccagaacacataa	20	8	5	8	0	2	1	2	0	0	1	3	3	3	2	2	1	2	0	2	1	7	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:141771238T>C	uc002tvj.1	-	14	3239	c.2267A>G	c.(2266-2268)TAT>TGT	p.Y756C	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	756	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCATTCATATAATCAGTCCA	0.388										TSP Lung(27;0.18)			45	52					0	0	0	0	C	141771238	C	C	141771238	3	2	70	1	0	0	0	0	1	0	0	0	9005	1406	49	5	11844	5	LRP1B	2	141771238	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	6032632	141771238	101428135	58	14212											
DPP4	1803	broad.mit.edu	37	chr2	162865118	162865118	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccacggctattccacacttGaacacgccacttcccgatcc	9	8	6	18	3	0	1	0	1	0	0	3	2	3	1	5	1	1	1	5	1	2	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:162865118G>C	uc002ubz.2	-	22	2502	c.1941C>G	c.(1939-1941)TTC>TTG	p.F647L	DPP4_uc010fpb.2_Missense_Mutation_p.F323L	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	647	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	TTCCACACTTGAACACGCCAC	0.468													16	48					0	0	0	0	C	162865118	C	C	162865118	3	2	70	1	0	0	0	0	1	0	0	0	4751	1281	45	2	379	2	DPP4	2	162865118	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	21093880	162865118	80334255	59	14213											
IFIH1	64135	broad.mit.edu	37	chr2	163128753	163128753	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccttatgagcatactcctCtggtttcatattttgaacac	10	16	5	10	0	2	2	1	2	1	0	3	2	3	2	2	1	4	2	2	1	5	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:163128753C>G	uc002uce.2	-	13	2821	c.2599G>C	c.(2599-2601)GAG>CAG	p.E867Q		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	867	Helicase C-terminal.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						GCATACTCCTCTGGTTTCATA	0.378													6	19					0	0	0	0	G	163128753	G	G	163128753	3	3	70	1	0	0	0	0	1	0	0	0	7559	922	32	2	494	2	IFIH1	2	163128753	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	263635	163128753	80070620	60	14214											
IFIH1	64135	broad.mit.edu	37	chr2	163144765	163144765	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgtagggaggcagatgatGatattcttcccttccaaggc	9	11	11	10	0	1	3	0	2	1	1	3	4	3	4	3	3	0	2	3	3	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:163144765G>A	uc002uce.2	-	5	1197	c.975C>T	c.(973-975)ATC>ATT	p.I325I		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	325	Helicase ATP-binding.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						GGCAGATGATGATATTCTTCC	0.493													27	66					0	0	0	0	A	163144765	A	A	163144765	2	1	70	1	0	0	0	0	0	0	0	1	7559	1280	45	2		2	IFIH1	2	163144765	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	16012	163144765	80054608	61	14215											
SCN3A	6328	broad.mit.edu	37	chr2	165984368	165984368	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attaagctctttgcttatttCaattccagtattattggaca	11	18	5	7	0	2	0	1	0	1	0	3	1	3	1	1	1	2	3	1	1	5	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:165984368C>G	uc002ucx.2	-	18	3658	c.3166G>C	c.(3166-3168)GAA>CAA	p.E1056Q	SCN3A_uc002ucy.2_Missense_Mutation_p.E1007Q|SCN3A_uc002ucz.2_Missense_Mutation_p.E1007Q|SCN3A_uc002uda.1_Missense_Mutation_p.E876Q|SCN3A_uc002udb.1_Missense_Mutation_p.E876Q	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1056						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTGCTTATTTCAATTCCAGTA	0.373													16	58					0	0	0	0	G	165984368	G	G	165984368	3	3	70	1	0	0	0	0	1	0	0	0	13983	835	29	2	2880	2	SCN3A	2	165984368	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2839603	165984368	77215005	62	14216											
SCN1A	6323	broad.mit.edu	37	chr2	166901607	166901607	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcggttcccttcaatggaGaagcgaaaacctttcctcct	11	11	7	12	2	1	1	1	0	0	1	5	3	4	1	4	2	2	1	4	2	5	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:166901607G>A	uc010zcz.1	-	10	1626	c.1608C>T	c.(1606-1608)TTC>TTT	p.F536F	SCN1A_uc002udo.3_Silent_p.F405F|SCN1A_uc010fpk.2_Silent_p.F405F	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	536						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CTTCAATGGAGAAGCGAAAAC	0.428													13	104					0	0	0	0	A	166901607	A	A	166901607	2	1	70	1	0	0	0	0	0	0	0	1	13979	933	33	2		2	SCN1A	2	166901607	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	917239	166901607	76297766	63	14217											
XIRP2	129446	broad.mit.edu	37	chr2	168107923	168107923	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagatggttcagggaatttGagcatggcccagtttctgaa	11	11	12	7	0	2	3	1	2	1	1	2	4	2	4	1	3	1	3	1	3	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:168107923G>C	uc002udx.2	+	8	10039	c.10021G>C	c.(10021-10023)GAG>CAG	p.E3341Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E3166Q|XIRP2_uc010fpq.2_Missense_Mutation_p.E3119Q|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3166				E -> G (in Ref. 8; CAD91141).	actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAGGGAATTTGAGCATGGCCC	0.393													19	67					0	0	0	0	C	168107923	C	C	168107923	3	2	70	1	0	0	0	0	1	0	0	0	17498	1291	45	2	10051	2	XIRP2	2	168107923	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1206316	168107923	75091450	64	14218											
TLK1	9874	broad.mit.edu	37	chr2	171854298	171854298	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttggaaatctttggtggcTcttttccaactacaaaacac	11	14	7	9	0	2	0	0	0	2	0	3	1	3	1	1	3	3	2	1	3	5	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:171854298T>C	uc002ugn.2	-	19	2412	c.1940A>G	c.(1939-1941)GAG>GGG	p.E647G	TLK1_uc002ugo.2_Missense_Mutation_p.E668G|TLK1_uc002ugp.2_Missense_Mutation_p.E599G|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Missense_Mutation_p.E551G	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	647	Protein kinase.				cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						CTTTGGTGGCTCTTTTCCAAC	0.373													94	94					0	0	0	0	C	171854298	C	C	171854298	3	2	70	1	0	0	0	0	1	0	0	0	16009	1551	54	5	372	5	TLK1	2	171854298	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	3746375	171854298	71345075	65	14219											
SCRN3	79634	broad.mit.edu	37	chr2	175264800	175264800	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagagaagaagtttgtgatGaagaagcactattaggaatg	17	9	13	2	0	0	5	0	2	0	3	0	8	0	6	0	1	1	2	0	1	8	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:175264800G>A	uc002uiq.2	+	3	398	c.310G>A	c.(310-312)GAA>AAA	p.E104K	SCRN3_uc010zen.1_Missense_Mutation_p.E97K|SCRN3_uc010zeo.1_5'UTR|SCRN3_uc002uir.1_RNA	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	104					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			AGTTTGTGATGAAGAAGCACT	0.408													38	126					0	0	0	0	A	175264800	A	A	175264800	3	1	70	1	0	0	0	0	1	0	0	0	14005	1291	45	2	316	2	SCRN3	2	175264800	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3410502	175264800	67934573	66	14220											
CHN1	1123	broad.mit.edu	37	chr2	175666502	175666502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcagtagtttcagtgcttCatgaagggtttccaattgct	8	15	11	7	0	2	1	2	1	0	0	3	1	3	1	1	2	2	6	1	2	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:175666502C>T	uc002uji.2	-	12	1671	c.1141G>A	c.(1141-1143)GAA>AAA	p.E381K	CHN1_uc010zeq.1_Missense_Mutation_p.E355K|CHN1_uc002ujj.2_Missense_Mutation_p.E156K|CHN1_uc002ujg.2_Missense_Mutation_p.E256K	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	381	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			TTCAGTGCTTCATGAAGGGTT	0.408			T	TAF15	extraskeletal myxoid chondrosarcoma								30	107					0	0	0	0	T	175666502	T	T	175666502	3	4	70	1	0	0	0	0	1	0	0	0	3377	835	29	2	246	2	CHN1	2	175666502	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	401702	175666502	67532871	67	14221											
TTN	7273	broad.mit.edu	37	chr2	179599449	179599449	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaacctttgataactatttCagtactgcagctatcactgc	12	13	5	11	0	2	1	2	1	0	0	2	1	2	1	1	0	6	3	1	0	5	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:179599449C>T	uc010zfg.1	-	48	11694	c.11470G>A	c.(11470-11472)GAA>AAA	p.E3824K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E485K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4751							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAACTATTTCAGTACTGCAG	0.363													19	80					0	0	0	0	T	179599449	T	T	179599449	3	4	70	1	0	0	0	0	1	0	0	0	16803	835	29	2	89575	2	TTN	2	179599449	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3932947	179599449	63599924	68	14222											
TTN	7273	broad.mit.edu	37	chr2	179640236	179640236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagatccggtcagaccgttCaattttgacaccatttttgt	9	15	8	9	2	2	3	2	1	0	2	3	3	3	3	3	1	0	2	3	1	2	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:179640236C>T	uc010zfg.1	-	28	6579	c.6355G>A	c.(6355-6357)GAA>AAA	p.E2119K	TTN_uc010zfh.1_Missense_Mutation_p.E2073K|TTN_uc010zfi.1_Missense_Mutation_p.E2073K|TTN_uc010zfj.1_Missense_Mutation_p.E2073K|TTN_uc002unb.2_Missense_Mutation_p.E2119K|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2119							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGACCGTTCAATTTTGACA	0.493													9	22					0	0	0	0	T	179640236	T	T	179640236	3	4	70	1	0	0	0	0	1	0	0	0	16803	835	29	2	104973	2	TTN	2	179640236	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	40787	179640236	63559137	69	14223											
CERKL	375298	broad.mit.edu	37	chr2	182468711	182468711	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taataaagtaccacttctctGctgtttaacagaacaacgcc	14	11	5	11	1	1	1	0	0	1	1	2	1	1	1	2	0	5	3	2	0	7	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:182468711G>T	uc002unx.2	-	2	435	c.334C>A	c.(334-336)CAG>AAG	p.Q112K	CERKL_uc002uny.2_Missense_Mutation_p.Q112K|CERKL_uc010zfm.1_Missense_Mutation_p.Q112K|CERKL_uc002unz.2_5'UTR|CERKL_uc002uoa.2_Missense_Mutation_p.Q112K|CERKL_uc002uob.2_5'UTR|CERKL_uc002uoc.2_Missense_Mutation_p.Q112K|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_5'UTR|CERKL_uc002uoe.2_Missense_Mutation_p.Q112K	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	112					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CCACTTCTCTGCTGTTTAACA	0.318													17	11					1.5739e-10	1.67544e-10	1	0	T	182468711	T	T	182468711	3	4	70	1	0	0	0	0	1	0	0	0	3283	1328	46	4	1394	4	CERKL	2	182468711	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2828475	182468711	60730662	70	14224											
SSFA2	6744	broad.mit.edu	37	chr2	182767020	182767020	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaggaatctggtattgtaGaatccaaattagatagtgat	14	13	11	3	0	1	4	0	2	1	2	2	5	2	5	1	2	0	2	1	2	7	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:182767020G>C	uc002uoi.2	+	8	1562	c.1240G>C	c.(1240-1242)GAA>CAA	p.E414Q	SSFA2_uc002uoh.2_Missense_Mutation_p.E414Q|SSFA2_uc002uoj.2_Missense_Mutation_p.E414Q|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.E261Q|SSFA2_uc002uol.2_Missense_Mutation_p.E261Q	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	414						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TGGTATTGTAGAATCCAAATT	0.368													13	50					0	0	0	0	C	182767020	C	C	182767020	3	2	70	1	0	0	0	0	1	0	0	0	15249	943	33	2	1270	2	SSFA2	2	182767020	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	298309	182767020	60432353	71	14225											
DNAH7	56171	broad.mit.edu	37	chr2	196673414	196673414	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttaaaacataccaaactatCatatactttcttccatccat	15	14	1	11	0	2	0	1	0	1	0	4	0	4	0	3	0	4	1	3	0	7	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:196673414C>T	uc002utj.3	-	53	10176	c.10075G>A	c.(10075-10077)GAT>AAT	p.D3359N		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3359					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ACCAAACTATCATATACTTTC	0.323													21	94					0	0	0	0	T	196673414	T	T	196673414	3	4	70	1	0	0	0	0	1	0	0	0	4628	826	29	2	2051	2	DNAH7	2	196673414	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	13906394	196673414	46525959	72	14226											
DNAH7	56171	broad.mit.edu	37	chr2	196729233	196729233	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgcacatttccttaagatCacttttaaatcttcatgcca	11	15	3	12	1	3	1	2	0	1	1	5	1	5	1	3	0	1	1	3	0	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:196729233C>G	uc002utj.3	-	41	7247	c.7146G>C	c.(7144-7146)GTG>GTC	p.V2382V		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2382	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCCTTAAGATCACTTTTAAAT	0.398													16	71					0	0	0	0	G	196729233	G	G	196729233	2	3	70	1	0	0	0	0	0	0	0	1	4628	813	29	2		2	DNAH7	2	196729233	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	55819	196729233	46470140	73	14227											
SF3B1	23451	broad.mit.edu	37	chr2	198265441	198265441	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cataatagttttcattacctCtgtagtctgttcttggaaag	10	17	7	7	0	4	0	1	0	3	0	4	1	4	1	1	1	1	3	1	1	5	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:198265441C>T	uc002uue.2	-	18	2764	c.2716G>A	c.(2716-2718)GAG>AAG	p.E906K		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	906					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TTCATTACCTCTGTAGTCTGT	0.308													16	77					0	0	0	0	T	198265441	T	T	198265441	3	4	70	1	0	0	0	0	1	0	0	0	14214	922	32	2	1230	2	SF3B1	2	198265441	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1536208	198265441	44933932	74	14228											
CTLA4	1493	broad.mit.edu	37	chr2	204732684	204732684	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatggcttgccttggatttCagcggcacaaggctcagctg	7	10	12	12	1	2	0	2	0	0	0	2	1	2	1	2	4	3	4	2	4	1	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:204732684C>T	uc002vak.1	+	1	176	c.19C>T	c.(19-21)CAG>TAG	p.Q7*	CTLA4_uc002val.1_Nonsense_Mutation_p.Q7*|CTLA4_uc010fty.1_Nonsense_Mutation_p.Q7*|CTLA4_uc010ftz.1_RNA	NM_005214	NP_005205	P16410	CTLA4_HUMAN	cytotoxic T-lymphocyte-associated protein 4	7					B cell receptor signaling pathway|immune response|negative regulation of B cell proliferation|negative regulation of regulatory T cell differentiation|positive regulation of apoptosis|response to DNA damage stimulus|T cell costimulation	clathrin-coated endocytic vesicle|external side of plasma membrane|Golgi apparatus|integral to plasma membrane|perinuclear region of cytoplasm					0					Abatacept(DB01281)	CCTTGGATTTCAGCGGCACAA	0.498													14	18					0	0	0	0	T	204732684	T	T	204732684	4	4	70	1	0	0	0	0	0	1	0	0	4028	827	29	2	21	2	CTLA4	2	204732684	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	6467243	204732684	38466689	75	14229											
COL4A3	1285	broad.mit.edu	37	chr2	228159768	228159768	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctggtccagccggagaaaaGggagaaacgggtacaacttg	13	5	14	9	2	0	2	0	0	0	2	1	4	1	2	3	4	4	1	3	4	5	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:228159768G>A	uc002vom.1	+	40	3669	c.3507G>A	c.(3505-3507)AAG>AAA	p.K1169K	COL4A3_uc002von.1_Silent_p.K1169K|COL4A3_uc002voo.1_Silent_p.K1169K|COL4A3_uc002vop.1_Silent_p.K1169K|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1169	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CCGGAGAAAAGGGAGAAACGG	0.408													54	25					0	0	0	0	A	228159768	A	A	228159768	2	1	70	1	0	0	0	0	0	0	0	1	3706	991	35	4		4	COL4A3	2	228159768	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	23427084	228159768	15039605	76	14230											
SP100	6672	broad.mit.edu	37	chr2	231368918	231368918	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggtccaagaattcccaaaGatgaaaatattaattttaaa	19	11	5	6	0	0	3	0	1	0	2	2	3	2	3	2	1	0	0	2	1	9	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:231368918G>C	uc002vqt.2	+	21	1924	c.1783G>C	c.(1783-1785)GAT>CAT	p.D595H	SP100_uc002vqs.2_Missense_Mutation_p.D595H|SP100_uc002vqu.1_Missense_Mutation_p.D595H|SP100_uc010fxp.1_5'UTR	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	595	SAND.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AATTCCCAAAGATGAAAATAT	0.403													20	50					0	0	0	0	C	231368918	C	C	231368918	3	2	70	1	0	0	0	0	1	0	0	0	15024	942	33	2	1865	2	SP100	2	231368918	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3209150	231368918	11830455	77	14231											
ARMC9	80210	broad.mit.edu	37	chr2	232143099	232143099	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatttgtttcccatagggaaGaacatgtgtgccaaggtggc	10	11	13	7	0	0	1	0	0	0	1	1	3	1	2	2	3	2	1	2	3	4	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:232143099G>A	uc002vrq.3	+	16	1591	c.1479G>A	c.(1477-1479)AAG>AAA	p.K493K	ARMC9_uc002vrp.3_Silent_p.K493K|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	493							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		CCATAGGGAAGAACATGTGTG	0.363													27	82					0	0	0	0	A	232143099	A	A	232143099	2	1	70	1	0	0	0	0	0	0	0	1	960	933	33	2		2	ARMC9	2	232143099	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	774181	232143099	11056274	78	14232											
HDAC4	9759	broad.mit.edu	37	chr2	239990186	239990186	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catatgcagaaccacttacaTctggcggagaggttgtagcc	11	9	11	10	1	1	2	0	0	1	2	1	3	1	2	2	3	4	3	2	3	4	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:239990186T>C	uc002vyk.3	-	23	3645	c.2853A>G	c.(2851-2853)AGA>AGG	p.R951R	HDAC4_uc010fyy.2_Silent_p.R908R	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	951	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		ACCACTTACATCTGGCGGAGA	0.572													4	22					0	0	0	0	C	239990186	C	C	239990186	2	2	70	1	0	0	0	0	0	0	0	1	7048	1449	50	5		5	HDAC4	2	239990186	Silent	SNP	T	TCGA-CN-6011-01A-11D-1683-08	7847087	239990186	3209187	79	14233											
CNTN4	152330	broad.mit.edu	37	chr3	3067795	3067795	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taactctccagatccaacaaGggtaatggtacccccttcca	12	9	6	14	0	1	1	0	0	1	1	4	1	3	1	5	2	3	2	5	2	5	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:3067795G>A	uc003bpc.2	+	14	1717	c.1496G>A	c.(1495-1497)AGG>AAG	p.R499K	CNTN4_uc003bpb.1_Missense_Mutation_p.R171K|CNTN4_uc003bpd.1_Missense_Mutation_p.R499K|CNTN4_uc003bpe.2_Missense_Mutation_p.R171K|CNTN4_uc003bpf.2_Missense_Mutation_p.R171K	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	499	Ig-like C2-type 6.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GATCCAACAAGGGTAATGGTA	0.418													5	11					0	0	0	0	A	3067795	A	A	3067795	3	1	70	1	0	0	0	0	1	0	0	0	3658	1000	35	4	1542	4	CNTN4	3	3067795	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08		3067795	194954635	80	14234											
CRELD1	78987	broad.mit.edu	37	chr3	9979744	9979744	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagtggctgtgctcagattcCctgaagctctgctgccccgc	5	10	11	15	1	2	2	1	1	1	1	3	2	3	2	3	1	4	4	3	1	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:9979744C>T	uc003bug.2	+	5	532	c.414C>T	c.(412-414)TCC>TCT	p.S138S	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Silent_p.S138S|CRELD1_uc003buh.2_Silent_p.S138S|CRELD1_uc003bui.2_Silent_p.S138S|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	138	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						GCTCAGATTCCCTGAAGCTCT	0.592													19	5					0	0	0	0	T	9979744	T	T	9979744	2	4	70	1	0	0	0	0	0	0	0	1	3881	610	22	4		4	CRELD1	3	9979744	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	6911949	9979744	188042686	81	14235											
BTD	686	broad.mit.edu	37	chr3	15677117	15677117	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaaccctctggctctcatCagccgccaagaggccttgga	8	8	10	15	1	3	2	2	1	2	1	4	3	3	3	4	3	2	1	4	3	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:15677117C>T	uc003cah.2	+	2	334	c.231C>T	c.(229-231)ATC>ATT	p.I77I	BTD_uc011avv.1_Silent_p.I79I|BTD_uc011avw.1_Silent_p.I79I|BTD_uc011avx.1_Silent_p.I57I	NM_000060	NP_000051	P43251	BTD_HUMAN	biotinidase precursor	77	CN hydrolase.				central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity				0						TGGCTCTCATCAGCCGCCAAG	0.542													30	54					0	0	0	0	T	15677117	T	T	15677117	2	4	70	1	0	0	0	0	0	0	0	1	1555	816	29	2		2	BTD	3	15677117	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	5697373	15677117	182345313	82	14236											
TOP2B	7155	broad.mit.edu	37	chr3	25666199	25666199	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgatgataagccgacatctCagcaacagagccagccaact	15	6	8	12	1	1	3	1	2	1	1	2	4	1	3	3	0	6	1	3	0	3	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:25666199C>T	uc011awn.1	-	19	2363	c.2320G>A	c.(2320-2322)GAG>AAG	p.E774K	TOP2B_uc003cdj.2_Missense_Mutation_p.E769K	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	774					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GCCGACATCTCAGCAACAGAG	0.363													4	14					0	0	0	0	T	25666199	T	T	25666199	3	4	70	1	0	0	0	0	1	0	0	0	16433	835	29	2	2632	2	TOP2B	3	25666199	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	9989082	25666199	172356231	83	14237											
NBEAL2	23218	broad.mit.edu	37	chr3	47030591	47030591	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaggaacctggagaacataGaggcaggccggggccaagtg	12	3	16	10	1	0	2	0	0	0	2	0	4	0	3	4	6	2	1	4	6	4	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:47030591G>C	uc003cqp.2	+	4	465	c.286G>C	c.(286-288)GAG>CAG	p.E96Q	NBEAL2_uc003cqq.1_Missense_Mutation_p.E89Q	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	96							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GGAGAACATAGAGGCAGGCCG	0.597													8	10					0	0	0	0	C	47030591	C	C	47030591	3	2	70	1	0	0	0	0	1	0	0	0	10242	943	33	2	300	2	NBEAL2	3	47030591	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	21364392	47030591	150991839	84	14238											
ERC2	26059	broad.mit.edu	37	chr3	55984542	55984542	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcttcttttccaactgttGattgtgcttgaggttggcca	5	19	9	8	0	2	2	0	2	2	0	3	2	3	2	2	2	2	3	2	2	1	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:55984542G>A	uc003dhr.1	-	13	2570	c.2314C>T	c.(2314-2316)CAA>TAA	p.Q772*	ERC2_uc003dhq.1_RNA|ERC2_uc003dht.1_Nonsense_Mutation_p.Q251*	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	772	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TCCAACTGTTGATTGTGCTTG	0.433													14	30					0	0	0	0	A	55984542	A	A	55984542	4	1	70	1	0	0	0	0	0	1	0	0	5235	1299	45	2	579	2	ERC2	3	55984542	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	8953951	55984542	142037888	85	14239											
CNTN3	5067	broad.mit.edu	37	chr3	74535745	74535745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	attcaacttataacgatgttCcatactcatatcaatatcac	15	14	2	10	1	4	0	4	0	0	0	5	1	5	0	1	0	3	1	1	0	7	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:74535745C>T	uc003dpm.1	-	3	300	c.220G>A	c.(220-222)GAA>AAA	p.E74K		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	74	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TAACGATGTTCCATACTCATA	0.363													16	32					0	0	0	0	T	74535745	T	T	74535745	3	4	70	1	0	0	0	0	1	0	0	0	3657	864	30	2	2946	2	CNTN3	3	74535745	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	18551203	74535745	123486685	86	14240											
LSAMP	4045	broad.mit.edu	37	chr3	115560764	115560764	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtgtagttgccgtagtgctCctcagtgacgttggtcaccg	5	12	14	10	3	2	1	2	1	0	0	3	1	3	1	3	2	2	5	3	2	2	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:115560764C>T	uc003ebt.2	-	6	1347	c.847G>A	c.(847-849)GAG>AAG	p.E283K	LSAMP_uc011bis.1_Missense_Mutation_p.E283K	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	283	Ig-like C2-type 3.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CCGTAGTGCTCCTCAGTGACG	0.507													10	34					0	0	0	0	T	115560764	T	T	115560764	3	4	70	1	0	0	0	0	1	0	0	0	9098	864	30	2	177	2	LSAMP	3	115560764	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	41025019	115560764	82461666	87	14241											
KTELC1	56983	broad.mit.edu	37	chr3	119198980	119198980	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttggccaatttatcctacagGtcttggacggtgggacctct	7	13	11	10	1	2	0	0	0	2	0	3	2	3	2	3	5	1	0	3	5	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:119198980G>T	uc003ecm.2	+	5	623	c.539G>T	c.(538-540)GGT>GTT	p.G180V	KTELC1_uc011biz.1_RNA|KTELC1_uc011bja.1_Missense_Mutation_p.G21V	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	180						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		TATCCTACAGGTCTTGGACGG	0.418													30	15					1.30897e-18	1.42405e-18	1	0	T	119198980	T	T	119198980	3	4	70	1	0	0	0	0	1	0	0	0	8623	1261	44	4	557	4	KTELC1	3	119198980	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3638216	119198980	78823450	88	14242											
SEC61A1	29927	broad.mit.edu	37	chr3	127774526	127774526	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgttcccagattcccctgtTtgggatcatgtcttcagatt	6	16	8	11	0	3	2	2	0	1	2	5	3	5	3	3	1	0	2	3	1	0	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:127774526T>A	uc003ekb.2	+	4	336	c.152T>A	c.(151-153)TTT>TAT	p.F51Y	SEC61A1_uc003ekc.2_Translation_Start_Site|SEC61A1_uc003ekd.2_Intron	NM_013336	NP_037468	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit	51	Helical; (Potential).				protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			ovary(1)	1						ATTCCCCTGTTTGGGATCATG	0.473													31	109					0	0	0	0	A	127774526	A	A	127774526	3	1	70	1	0	0	0	0	1	0	0	0	14065	1841	64	5	166	5	SEC61A1	3	127774526	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	8575546	127774526	70247904	89	14243											
COPB2	9276	broad.mit.edu	37	chr3	139093334	139093334	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atacccttctaacttaccatCttctgaacctgtgataatga	12	14	4	11	0	3	3	0	3	3	0	3	3	3	3	3	0	4	0	3	0	5	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:139093334C>T	uc003etf.3	-	7	878	c.748G>A	c.(748-750)GAT>AAT	p.D250N	COPB2_uc011bmv.1_Missense_Mutation_p.D221N|COPB2_uc010hui.2_Missense_Mutation_p.D221N|COPB2_uc011bmw.1_Missense_Mutation_p.D250N	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	250	WD 6.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						AACTTACCATCTTCTGAACCT	0.403													30	70					0	0	0	0	T	139093334	T	T	139093334	3	4	70	1	0	0	0	0	1	0	0	0	3744	913	32	2	2036	2	COPB2	3	139093334	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	11318808	139093334	58929096	90	14244											
PLSCR4	57088	broad.mit.edu	37	chr3	145918834	145918834	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacatactttccagaggctCaaaatgctgaagaacatgta	16	10	7	8	0	1	3	1	1	0	2	2	3	2	3	1	1	4	3	1	1	7	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:145918834C>G	uc010huy.2	-	5	714	c.385G>C	c.(385-387)GAG>CAG	p.E129Q	PLSCR4_uc010huz.2_Missense_Mutation_p.E129Q|PLSCR4_uc003evt.3_Missense_Mutation_p.E129Q|PLSCR4_uc010hva.2_Intron|PLSCR4_uc003evu.3_Intron	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	129	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						TCCAGAGGCTCAAAATGCTGA	0.318													8	39					0	0	0	0	G	145918834	G	G	145918834	3	3	70	1	0	0	0	0	1	0	0	0	12167	835	29	2	624	2	PLSCR4	3	145918834	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	6825500	145918834	52103596	91	14245											
MME	4311	broad.mit.edu	37	chr3	154834751	154834751	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgttggcactgatgataaGaattctgtgaatcatgtaat	12	16	9	4	0	2	4	1	3	1	1	2	4	2	4	0	1	0	3	0	1	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:154834751G>A	uc010hvr.1	+	7	841	c.630G>A	c.(628-630)AAG>AAA	p.K210K	MME_uc003fab.1_Silent_p.K210K|MME_uc003fac.1_Silent_p.K210K|MME_uc003fad.1_Silent_p.K210K|MME_uc003fae.1_Silent_p.K210K	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	210	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CTGATGATAAGAATTCTGTGA	0.299													7	29					0	0	0	0	A	154834751	A	A	154834751	2	1	70	1	0	0	0	0	0	0	0	1	9698	933	33	2		2	MME	3	154834751	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	8915917	154834751	43187679	92	14246											
VEPH1	79674	broad.mit.edu	37	chr3	156978935	156978935	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataaatccctacagatatgtGgttacttctctactttccct	10	16	4	11	0	1	1	0	0	1	1	4	1	3	1	2	1	3	1	2	1	6	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:156978935G>C	uc003fbj.1	-	14	2807	c.2490C>G	c.(2488-2490)ACC>ACG	p.T830T	VEPH1_uc003fbk.1_Silent_p.T830T|VEPH1_uc010hvu.1_Silent_p.T785T	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	830						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			ACAGATATGTGGTTACTTCTC	0.408													14	74					0	0	0	0	C	156978935	C	C	156978935	2	2	70	1	0	0	0	0	0	0	0	1	17222	1335	47	4		4	VEPH1	3	156978935	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2144184	156978935	41043495	93	14247											
PLD1	5337	broad.mit.edu	37	chr3	171323140	171323140	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgaaacccacacctccttGaagaatttgtcactcactgg	11	11	7	12	0	2	3	2	2	0	1	3	3	3	3	3	1	1	1	3	1	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:171323140G>C	uc003fhs.2	-	26	3065	c.2949C>G	c.(2947-2949)TTC>TTG	p.F983L	PLD1_uc003fht.2_Missense_Mutation_p.F945L	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	983					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ACACCTCCTTGAAGAATTTGT	0.443													33	95					0	0	0	0	C	171323140	C	C	171323140	3	2	70	1	0	0	0	0	1	0	0	0	12100	1281	45	2	283	2	PLD1	3	171323140	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	14344205	171323140	26699290	94	14248											
MCF2L2	23101	broad.mit.edu	37	chr3	182923663	182923663	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagtcagcaggggtaacctaCctttgatattattttgttgt	10	16	9	6	0	1	1	1	1	0	0	1	1	1	1	2	2	3	3	2	2	5	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:182923663C>T	uc003fli.1	-	25	2974	c.2884_splice	c.e25+1	p.D962_splice		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GGGTAACCTACCTTTGATATT	0.378													3	21					0	0	0	0	T	182923663	T	T	182923663	5	4	70	1	0	0	0	0	0	0	1	0	9433	521	18	4	483	4	MCF2L2	3	182923663	Splice_Site	SNP	C	TCGA-CN-6011-01A-11D-1683-08	11600523	182923663	15098767	95	14249											
MAP3K13	9175	broad.mit.edu	37	chr3	185183579	185183579	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctatgagcggaagcttgagcGggcgaataatttatacatgg	12	10	13	6	3	0	2	0	2	0	0	0	4	0	3	0	3	4	1	0	3	6	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:185183579G>A	uc010hyf.2	+	10	1699	c.1433G>A	c.(1432-1434)CGG>CAG	p.R478Q	MAP3K13_uc011brt.1_Missense_Mutation_p.R271Q|MAP3K13_uc011bru.1_Missense_Mutation_p.R334Q|MAP3K13_uc003fpi.2_Missense_Mutation_p.R478Q|MAP3K13_uc010hyg.2_Missense_Mutation_p.R168Q	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	478					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAGCTTGAGCGGGCGAATAAT	0.473													19	87					0	0	0	0	A	185183579	A	A	185183579	3	1	70	1	0	0	0	0	1	0	0	0	9300	1116	39	1	1463	1	MAP3K13	3	185183579	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2259916	185183579	12838851	96	14250											
ACAP2	23527	broad.mit.edu	37	chr3	195015475	195015475	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atataaactattggctgacaCcgtggagggtaaagattctc	13	11	10	7	1	1	2	0	1	1	1	2	3	1	3	1	3	1	2	1	3	6	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:195015475C>A	uc003fun.3	-	18	1979	c.1738G>T	c.(1738-1740)GTG>TTG	p.V580L		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	580					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TTGGCTGACACCGTGGAGGGT	0.363													8	54					2.17888e-05	2.25637e-05	1	0	A	195015475	A	A	195015475	3	1	70	1	0	0	0	0	1	0	0	0	119	507	18	4	622	4	ACAP2	3	195015475	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	9831896	195015475	3006955	97	14251											
LRCH3	84859	broad.mit.edu	37	chr3	197553768	197553768	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagctggcggagttgcctttGatacggttagacttctcatg	7	13	13	8	2	1	2	1	1	1	1	2	4	1	3	1	3	3	3	1	3	2	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:197553768G>C	uc011bul.1	+	5	665	c.660G>C	c.(658-660)TTG>TTC	p.L220F	LRCH3_uc003fyj.1_Missense_Mutation_p.L220F|LRCH3_uc011bum.1_Missense_Mutation_p.L220F|LRCH3_uc011bun.1_Missense_Mutation_p.L94F|LRCH3_uc003fyk.2_5'Flank	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	220	LRR 7.					extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		AGTTGCCTTTGATACGGTTAG	0.383													20	93					0	0	0	0	C	197553768	C	C	197553768	3	2	70	1	0	0	0	0	1	0	0	0	8984	1281	45	2	678	2	LRCH3	3	197553768	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2538293	197553768	468662	98	14252											
GSX2	170825	broad.mit.edu	37	chr4	54967925	54967925	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaggtgaaaatctggtttCagaaccgccgagtgaagcac	13	7	12	9	2	2	3	1	2	1	1	2	4	2	3	2	2	3	3	2	2	4	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:54967925C>G	uc010igp.1	+	2	1015	c.751C>G	c.(751-753)CAG>GAG	p.Q251E	PDGFRA_uc003haa.2_Intron	NM_133267	NP_573574	Q9BZM3	GSX2_HUMAN	GS homeobox 2	251	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			AATCTGGTTTCAGAACCGCCG	0.567													5	86					0	0	0	0	G	54967925	G	G	54967925	3	3	70	1	0	0	0	0	1	0	0	0	6889	827	29	2	757	2	GSX2	4	54967925	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08		54967925	136186351	99	14253											
LPHN3	23284	broad.mit.edu	37	chr4	62897307	62897307	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggaatgtttatatttattttCcattgtgtcctacagaagaa	12	17	7	5	0	0	2	0	0	0	2	2	3	2	3	2	1	1	1	2	1	7	9			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:62897307C>T	uc010ihh.2	+	20	3539	c.3366C>T	c.(3364-3366)TTC>TTT	p.F1122F	LPHN3_uc003hcq.3_Silent_p.F1122F|LPHN3_uc003hct.2_Silent_p.F506F	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1100	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TATTTATTTTCCATTGTGTCC	0.333													26	12					0	0	0	0	T	62897307	T	T	62897307	2	4	70	1	0	0	0	0	0	0	0	1	8967	854	30	2		2	LPHN3	4	62897307	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	7929382	62897307	128256969	100	14254											
CDKL2	8999	broad.mit.edu	37	chr4	76551024	76551024	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctttagtaacttgatttctCgcattgcaatctttttaacc	9	18	4	10	1	2	1	0	1	2	0	3	1	2	1	2	0	3	3	2	0	4	9			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:76551024C>T	uc003hiq.2	-	2	674	c.149G>A	c.(148-150)CGA>CAA	p.R50Q	CDKL2_uc011cbp.1_Missense_Mutation_p.R50Q|CDKL2_uc010iix.1_RNA	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	50	Protein kinase.|[NKR]KIAxRE.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CTTGATTTCTCGCATTGCAAT	0.299													13	35					0	0	0	0	T	76551024	T	T	76551024	3	4	70	1	0	0	0	0	1	0	0	0	3169	884	31	1	1372	1	CDKL2	4	76551024	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	13653717	76551024	114603252	101	14255											
SCD5	79966	broad.mit.edu	37	chr4	83719652	83719652	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttcttccttggcgtcgcaGaaagggatcttccccgcgtc	6	12	10	13	4	2	1	0	0	2	1	6	2	4	2	3	2	0	1	3	2	1	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:83719652G>C	uc003hna.2	-	1	359	c.39C>G	c.(37-39)TTC>TTG	p.F13L	SCD5_uc003hnb.3_Missense_Mutation_p.F13L|SCD5_uc003hnc.2_Missense_Mutation_p.F13L	NM_001037582	NP_001032671	Q86SK9	SCD5_HUMAN	stearoyl-CoA desaturase 5 isoform a	13					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			ovary(1)	1		Colorectal(4;0.0323)|Hepatocellular(203;0.115)				TGGCGTCGCAGAAAGGGATCT	0.736													6	6					0	0	0	0	C	83719652	C	C	83719652	3	2	70	1	0	0	0	0	1	0	0	0	13952	933	33	2	1179	2	SCD5	4	83719652	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	7168628	83719652	107434624	102	14256											
MMRN1	22915	broad.mit.edu	37	chr4	90857798	90857798	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acttgttgtatagatcgatcGttgcctggtagtctggcaaa	9	14	11	7	2	1	1	0	0	1	1	3	2	1	1	1	2	1	5	1	2	4	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:90857798G>A	uc003hst.2	+	6	3038	c.2967G>A	c.(2965-2967)TCG>TCA	p.S989S	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Silent_p.S731S	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	989					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TAGATCGATCGTTGCCTGGTA	0.353													36	16					0	0	0	0	A	90857798	A	A	90857798	2	1	70	1	0	0	0	0	0	0	0	1	9723	1132	40	1		1	MMRN1	4	90857798	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	7138146	90857798	100296478	103	14257											
BMPR1B	658	broad.mit.edu	37	chr4	96046186	96046186	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcattgggttagaacaggatGaaacttacattcctcctgga	12	11	10	8	0	0	2	0	1	0	1	2	4	2	4	2	3	3	2	2	3	4	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:96046186G>C	uc003htm.3	+	8	773	c.499G>C	c.(499-501)GAA>CAA	p.E167Q	BMPR1B_uc010ilb.2_Missense_Mutation_p.E167Q|BMPR1B_uc003htn.3_Missense_Mutation_p.E167Q	NM_001203	NP_001194	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	167	Cytoplasmic (Potential).				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			lung(4)|skin(2)|stomach(1)|breast(1)	8		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		AGAACAGGATGAAACTTACAT	0.408													10	21					0	0	0	0	C	96046186	C	C	96046186	3	2	70	1	0	0	0	0	1	0	0	0	1473	1291	45	2	517	2	BMPR1B	4	96046186	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	5188388	96046186	95108090	104	14258											
ADH4	127	broad.mit.edu	37	chr4	100062796	100062796	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctcaaatttagaatcgataAcagtggcatcagtatggcac	14	10	8	9	1	2	1	2	0	0	1	3	2	2	1	1	2	1	3	1	2	5	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:100062796A>G	uc003hun.2	-	3	234	c.158T>C	c.(157-159)GTT>GCT	p.V53A	uc003hum.1_Intron|ADH4_uc011ced.1_Missense_Mutation_p.V72A	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	53					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	AGAATCGATAACAGTGGCATC	0.443													18	32					0	0	0	0	G	100062796	G	G	100062796	3	3	70	1	0	0	0	0	1	0	0	0	310	43	2	5	1012	5	ADH4	4	100062796	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08	4016610	100062796	91091480	105	14259											
NFKB1	4790	broad.mit.edu	37	chr4	103534639	103534639	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgagacaaatgggctacaccGaagcaattgaagtgatccag	15	7	11	8	1	0	3	0	3	0	1	1	5	1	3	2	1	2	2	2	1	5	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:103534639G>A	uc011ceq.1	+	23	3114	c.2647G>A	c.(2647-2649)GAA>AAA	p.E883K	NFKB1_uc011cep.1_Missense_Mutation_p.E884K|NFKB1_uc011cer.1_Missense_Mutation_p.E703K	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	883	Death.|Interaction with CFLAR.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	GGGCTACACCGAAGCAATTGA	0.567													8	21					0	0	0	0	A	103534639	A	A	103534639	3	1	70	1	0	0	0	0	1	0	0	0	10429	1059	37	1	2736	1	NFKB1	4	103534639	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3471843	103534639	87619637	106	14260											
KIAA1109	84162	broad.mit.edu	37	chr4	123249442	123249442	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagtttgtcttctaccagtGaagattccgagaaggatgaa	13	11	10	7	1	2	4	0	2	2	2	3	6	3	5	2	1	1	1	2	1	4	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:123249442G>A	uc003ieh.2	+	64	11224	c.11179G>A	c.(11179-11181)GAA>AAA	p.E3727K	KIAA1109_uc003iem.2_Missense_Mutation_p.E118K	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3727					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTCTACCAGTGAAGATTCCGA	0.423													22	43					0	0	0	0	A	123249442	A	A	123249442	3	1	70	1	0	0	0	0	1	0	0	0	8247	1291	45	2	11433	2	KIAA1109	4	123249442	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	19714803	123249442	67904834	107	14261											
SPATA5	166378	broad.mit.edu	37	chr4	123977581	123977581	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatatgttggtgaatctgaaAgagcagttagagaggtaaga	16	10	13	2	0	1	5	0	2	1	3	1	6	1	5	0	2	1	4	0	2	6	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:123977581A>G	uc003iez.3	+	12	2192	c.2119A>G	c.(2119-2121)AGA>GGA	p.R707G		NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	707					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						TGAATCTGAAAGAGCAGTTAG	0.383													10	13					0	0	0	0	G	123977581	G	G	123977581	3	3	70	1	0	0	0	0	1	0	0	0	15077	64	3	5	2165	5	SPATA5	4	123977581	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08	728139	123977581	67176695	108	14262											
FAT4	79633	broad.mit.edu	37	chr4	126238739	126238739	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagattctcccgcggccaaCgggaacatctccgtgcaaat	10	7	10	14	4	2	1	0	0	2	1	4	2	2	2	3	2	3	2	3	2	3	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:126238739C>G	uc003ifj.3	+	1	1173	c.1173C>G	c.(1171-1173)AAC>AAG	p.N391K		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	391	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCGCGGCCAACGGGAACATCT	0.607											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	21					0	0	0	0	G	126238739	G	G	126238739	3	3	70	1	0	0	0	0	1	0	0	0	5724	535	19	3	1175	3	FAT4	4	126238739	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2261158	126238739	64915537	109	14263											
LARP1B	55132	broad.mit.edu	37	chr4	129043203	129043203	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccttatgtgaaaaaacatCctggaggagatcgaacaggc	15	7	10	9	1	0	2	0	1	0	1	2	5	1	3	2	3	2	0	2	3	5	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:129043203C>T	uc003iga.2	+	11	1515	c.1384C>T	c.(1384-1386)CCT>TCT	p.P462S	LARP1B_uc003igc.2_5'UTR|LARP1B_uc003ifz.1_Missense_Mutation_p.P462S|LARP1B_uc003igb.1_Missense_Mutation_p.P177S	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	462							RNA binding				0						GAAAAAACATCCTGGAGGAGA	0.368													41	38					0	0	0	0	T	129043203	T	T	129043203	3	4	70	1	0	0	0	0	1	0	0	0	8669	855	30	2	1507	2	LARP1B	4	129043203	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2804464	129043203	62111073	110	14264											
POU4F2	5458	broad.mit.edu	37	chr4	147561835	147561835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctactttgccattcagcctCggccctcctctgaaaagatc	8	11	6	16	1	2	2	1	1	1	1	5	2	3	2	5	1	3	0	5	1	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:147561835C>T	uc003ikv.2	+	2	1353	c.1105C>T	c.(1105-1107)CGG>TGG	p.R369W		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	369	Homeobox.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					CATTCAGCCTCGGCCCTCCTC	0.577													18	52					0	0	0	0	T	147561835	T	T	147561835	3	4	70	1	0	0	0	0	1	0	0	0	12334	875	31	1	1111	1	POU4F2	4	147561835	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	18518632	147561835	43592441	111	14265											
MAB21L2	10586	broad.mit.edu	37	chr4	151504859	151504859	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcaagcagagctcggcagaGagcgacgcctgggtgctaca	10	4	16	11	3	0	2	0	0	0	2	1	4	0	2	1	3	5	5	1	3	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:151504859G>C	uc003ilw.2	+	1	1783	c.678G>C	c.(676-678)GAG>GAC	p.E226D	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	226					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		GCTCGGCAGAGAGCGACGCCT	0.647													12	41					0	0	0	0	C	151504859	C	C	151504859	3	2	70	1	0	0	0	0	1	0	0	0	9193	933	33	2	680	2	MAB21L2	4	151504859	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3943024	151504859	39649417	112	14266											
NAF1	92345	broad.mit.edu	37	chr4	164069513	164069513	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctagttgttcaataatacttGaaaccatcccaagaggcttt	13	13	6	9	0	1	2	1	1	0	1	2	2	2	2	2	1	2	3	2	1	6	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:164069513G>C	uc003iqj.2	-	3	808	c.614C>G	c.(613-615)TCA>TGA	p.S205*	NAF1_uc010iqw.1_Nonsense_Mutation_p.S205*	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	205					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				AATAATACTTGAAACCATCCC	0.284													9	99					0	0	0	0	C	164069513	C	C	164069513	4	2	70	1	0	0	0	0	0	1	0	0	10193	1294	45	2	1035	2	NAF1	4	164069513	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	12564654	164069513	27084763	113	14267											
TKTL2	84076	broad.mit.edu	37	chr4	164393894	164393894	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttcatttgcacggcccagTttagccagagccaaaccata	11	10	7	13	1	1	1	1	0	0	1	1	1	1	1	4	1	4	2	4	1	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:164393894T>A	uc003iqp.3	-	1	1154	c.993A>T	c.(991-993)AAA>AAT	p.K331N		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	331						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				cacggcccagtttagccagag	0.194													28	82					0	0	0	0	A	164393894	A	A	164393894	3	1	70	1	0	0	0	0	1	0	0	0	16002	1722	60	5	891	5	TKTL2	4	164393894	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	324381	164393894	26760382	114	14268											
DDX60L	91351	broad.mit.edu	37	chr4	169317111	169317111	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taataattctctgacgtactGagtctttattcctggtaatt	10	18	6	7	1	2	2	0	2	2	0	4	2	3	2	1	1	1	2	1	1	5	9			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:169317111G>C	uc003irq.3	-	27	3877	c.3656C>G	c.(3655-3657)TCA>TGA	p.S1219*	DDX60L_uc003irr.1_Nonsense_Mutation_p.S1220*|DDX60L_uc003irs.1_Nonsense_Mutation_p.S914*	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1219	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CTGACGTACTGAGTCTTTATT	0.343													4	23					0	0	0	0	C	169317111	C	C	169317111	4	2	70	1	0	0	0	0	0	1	0	0	4396	1304	45	2	1512	2	DDX60L	4	169317111	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	4923217	169317111	21837165	115	14269											
DDX60L	91351	broad.mit.edu	37	chr4	169393962	169393962	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgatgtgaatggcacctcTgtaataaaagaaaaaataga	18	11	8	4	0	1	4	0	2	1	2	1	4	1	4	1	1	0	2	1	1	8	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:169393962T>C	uc003irq.3	-	2	112	c.-109_splice	c.e2-1		DDX60L_uc003irr.1_Splice_Site|DDX60L_uc003irt.1_Splice_Site	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like								ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		ATGGCACCTCTGTAATAAAAG	0.343													12	5					0	0	0	0	C	169393962	C	C	169393962	5	2	70	1	0	0	0	0	0	0	1	0	4396	1594	55	5		5	DDX60L	4	169393962	Splice_Site	SNP	T	TCGA-CN-6011-01A-11D-1683-08	76851	169393962	21760314	116	14270											
AADAT	51166	broad.mit.edu	37	chr4	170989840	170989840	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaaaatcctattctcaaccTacgtggaaagagaaaaggca	18	8	7	8	1	1	1	1	0	1	1	3	3	2	2	2	2	2	1	2	2	9	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:170989840T>G	uc003isr.2	-	8	1146	c.804_splice	c.e8-1	p.G268_splice	AADAT_uc003iss.2_Splice_Site_p.G268_splice|AADAT_uc003ist.2_Splice_Site_p.G272_splice	NM_016228	NP_057312	Q8N5Z0	AADAT_HUMAN	kynurenine aminotransferase II						2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity				0		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ATTCTCAACCTACGTGGAAAG	0.363													6	54					0	0	0	0	G	170989840	G	G	170989840	5	3	70	1	0	0	0	0	0	0	1	0	14	1536	53	5	499	5	AADAT	4	170989840	Splice_Site	SNP	T	TCGA-CN-6011-01A-11D-1683-08	1595878	170989840	20164436	117	14271											
SEMA5A	9037	broad.mit.edu	37	chr5	9154808	9154808	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcttaatggttccgtaatCtatgaaggtcacaggatgaa	12	14	9	6	1	3	2	1	2	2	0	4	3	4	3	1	3	0	2	1	3	5	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:9154808C>G	uc003jek.2	-	12	1986	c.1274_splice	c.e12-1	p.D425_splice		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor						cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GTTCCGTAATCTATGAAGGTC	0.498													29	130					0	0	0	0	G	9154808	G	G	9154808	5	3	70	1	0	0	0	0	0	0	1	0	14102	927	32	2	1999	2	SEMA5A	5	9154808	Splice_Site	SNP	C	TCGA-CN-6011-01A-11D-1683-08		9154808	171760452	118	14272											
DNAH5	1767	broad.mit.edu	37	chr5	13923469	13923469	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taccccagtaagagccacatCgtttccctcggtcacgaaca	11	8	7	15	3	1	1	1	0	0	1	4	2	2	1	4	1	3	2	4	1	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:13923469C>T	uc003jfd.2	-	4	400	c.358G>A	c.(358-360)GAT>AAT	p.D120N	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	120	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGAGCCACATCGTTTCCCTCG	0.458									Kartagener_syndrome				24	303					0	0	0	0	T	13923469	T	T	13923469	3	4	70	1	0	0	0	0	1	0	0	0	4626	884	31	1	13820	1	DNAH5	5	13923469	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	4768661	13923469	166991791	119	14273											
MYO10	4651	broad.mit.edu	37	chr5	16676206	16676206	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caaggggtgatgggtgtatcGaaggatcgggttccgcttgt	7	11	17	6	3	0	1	0	1	0	0	3	3	1	2	1	5	0	3	1	5	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:16676206G>A	uc003jft.3	-	34	5068	c.4600C>T	c.(4600-4602)CGA>TGA	p.R1534*	MYO10_uc011cnb.1_Nonsense_Mutation_p.R163*|MYO10_uc011cnc.1_Nonsense_Mutation_p.R413*|MYO10_uc011cnd.1_Nonsense_Mutation_p.R891*|MYO10_uc011cne.1_Nonsense_Mutation_p.R891*|MYO10_uc010itx.2_Nonsense_Mutation_p.R1156*	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1534					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TGGGTGTATCGAAGGATCGGG	0.493													19	141					0	0	0	0	A	16676206	A	A	16676206	4	1	70	1	0	0	0	0	0	1	0	0	10115	1066	37	1	1608	1	MYO10	5	16676206	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2752737	16676206	164239054	120	14274											
MTMR12	54545	broad.mit.edu	37	chr5	32230321	32230321	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagttgtcttggagctcatCagaagaattaataagtttgc	14	13	9	5	0	3	2	2	0	1	2	3	3	3	3	0	1	2	3	0	1	5	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:32230321C>G	uc003jhq.2	-	16	1977	c.1807G>C	c.(1807-1809)GAT>CAT	p.D603H	MTMR12_uc010iuk.2_Missense_Mutation_p.D549H|MTMR12_uc010iul.2_Missense_Mutation_p.D493H	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	603	Myotubularin phosphatase.					cytoplasm	phosphatase activity			ovary(1)	1						TGGAGCTCATCAGAAGAATTA	0.403													26	155					0	0	0	0	G	32230321	G	G	32230321	3	3	70	1	0	0	0	0	1	0	0	0	9994	826	29	2	440	2	MTMR12	5	32230321	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	15554115	32230321	148684939	121	14275											
TTC23L	153657	broad.mit.edu	37	chr5	34863022	34863022	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctcccagttcaggccaaGaaacatgctacatcagccaa	13	6	8	14	0	2	1	2	0	0	1	3	1	3	1	4	2	4	2	4	2	4	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:34863022G>T	uc003jiu.2	+	5	502	c.399G>T	c.(397-399)AAG>AAT	p.K133N	TTC23L_uc003jiv.2_5'Flank|TTC23L_uc010iut.1_5'Flank	NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	133							binding			central_nervous_system(1)	1						TTCAGGCCAAGAAACATGCTA	0.478													13	69					9.31168e-06	9.70375e-06	1	0	T	34863022	T	T	34863022	3	4	70	1	0	0	0	0	1	0	0	0	16759	933	33	2	413	2	TTC23L	5	34863022	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2632701	34863022	146052238	122	14276											
WDR70	55100	broad.mit.edu	37	chr5	37725096	37725096	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacaaggaaacagctggagaAggacagactggatcccctga	15	5	12	9	0	0	3	0	1	0	2	1	7	1	6	2	4	3	1	2	4	4	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:37725096A>G	uc003jkv.2	+	16	1716	c.1658A>G	c.(1657-1659)AAG>AGG	p.K553R		NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	553										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAGCTGGAGAAGGACAGACTG	0.502													119	103					0	0	0	0	G	37725096	G	G	37725096	3	3	70	1	0	0	0	0	1	0	0	0	17389	72	3	5	1720	5	WDR70	5	37725096	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08	2862074	37725096	143190164	123	14277											
EGFLAM	133584	broad.mit.edu	37	chr5	38451422	38451422	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtatttcctccagggtgtCaggatcaagatcaaatgtgt	10	13	11	7	0	3	1	3	0	0	1	5	2	5	2	2	2	0	1	2	2	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:38451422C>G	uc003jlc.1	+	20	2897	c.2573C>G	c.(2572-2574)TCA>TGA	p.S858*	EGFLAM_uc003jlb.1_Nonsense_Mutation_p.S850*|EGFLAM_uc003jle.1_Nonsense_Mutation_p.S616*|EGFLAM_uc003jlf.1_Nonsense_Mutation_p.S216*|EGFLAM_uc003jlg.1_5'UTR	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	858	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TCCAGGGTGTCAGGATCAAGA	0.478													38	297					0	0	0	0	G	38451422	G	G	38451422	4	3	70	1	0	0	0	0	0	1	0	0	4988	838	29	2	2637	2	EGFLAM	5	38451422	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	726326	38451422	142463838	124	14278											
RICTOR	253260	broad.mit.edu	37	chr5	38991111	38991111	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctctttcttgaagtccatCatttccaactgcaattaatg	10	16	5	10	0	3	1	1	1	2	0	6	1	5	1	2	0	2	1	2	0	4	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:38991111C>G	uc003jlp.2	-	7	547	c.523G>C	c.(523-525)GAT>CAT	p.D175H	RICTOR_uc003jlo.2_Missense_Mutation_p.D175H|RICTOR_uc010ivf.2_5'UTR|RICTOR_uc003jlq.1_Missense_Mutation_p.D159H|RICTOR_uc011cpk.1_Missense_Mutation_p.D175H	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	175					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TGAAGTCCATCATTTCCAACT	0.353													4	99					0	0	0	0	G	38991111	G	G	38991111	3	3	70	1	0	0	0	0	1	0	0	0	13423	826	29	2	4731	2	RICTOR	5	38991111	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	539689	38991111	141924149	125	14279											
PAIP1	10605	broad.mit.edu	37	chr5	43527498	43527498	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttactgttttcgcttacgctCtgattccaaacaaaactttt	10	17	4	10	2	1	1	0	1	1	0	3	1	2	1	1	0	4	3	1	0	5	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:43527498C>G	uc003job.2	-	11	1667	c.1420G>C	c.(1420-1422)GAG>CAG	p.E474Q	PAIP1_uc003joa.2_Missense_Mutation_p.E395Q|PAIP1_uc010ivp.2_3'UTR|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.E362Q	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	474	PABPC1-interacting motif-1 (PAM1).				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					CGCTTACGCTCTGATTCCAAA	0.338													8	79					0	0	0	0	G	43527498	G	G	43527498	3	3	70	1	0	0	0	0	1	0	0	0	11450	922	32	2	23	2	PAIP1	5	43527498	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	4536387	43527498	137387762	126	14280											
PAIP1	10605	broad.mit.edu	37	chr5	43527528	43527528	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaaaacttttcataagcttCttctatctctgggtccatct	10	16	4	11	0	5	0	1	0	4	0	7	0	6	0	1	1	2	1	1	1	4	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:43527528C>G	uc003job.2	-	11	1637	c.1390G>C	c.(1390-1392)GAA>CAA	p.E464Q	PAIP1_uc003joa.2_Missense_Mutation_p.E385Q|PAIP1_uc010ivp.2_3'UTR|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.E352Q	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	464	PABPC1-interacting motif-1 (PAM1).				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					TCATAAGCTTCTTCTATCTCT	0.328													11	81					0	0	0	0	G	43527528	G	G	43527528	3	3	70	1	0	0	0	0	1	0	0	0	11450	922	32	2	53	2	PAIP1	5	43527528	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	30	43527528	137387732	127	14281											
C5orf36	285600	broad.mit.edu	37	chr5	93859663	93859663	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgaaaaattttatcaagtctCcatgagaaatgaaagatgat	18	12	7	4	0	2	5	1	4	1	2	3	6	2	5	1	0	0	0	1	0	6	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:93859663C>G	uc011cuk.1	-	4	529	c.272G>C	c.(271-273)GGA>GCA	p.G91A	C5orf36_uc003kkp.2_Missense_Mutation_p.G91A	NM_001145678	NP_001139150	Q8IV33	K0825_HUMAN	hypothetical protein LOC285600 isoform 1	91											0		all_cancers(142;2.12e-08)|all_epithelial(76;5.95e-11)|all_lung(232;0.000996)|Lung NSC(167;0.0108)|Ovarian(174;0.0218)|Colorectal(57;0.0329)|Breast(839;0.214)|Lung SC(612;0.236)		all cancers(79;3.96e-19)		TATCAAGTCTCCATGAGAAAT	0.328													6	14					0	0	0	0	G	93859663	G	G	93859663	3	3	70	1	0	0	0	0	1	0	0	0	2305	855	30	2	3632	2	C5orf36	5	93859663	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	50332135	93859663	87055597	128	14282											
PRR16	51334	broad.mit.edu	37	chr5	120022237	120022237	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agattcctcaccaaggccctCccctccctcctacaccccat	8	8	3	22	0	1	1	1	0	0	1	5	1	5	1	9	1	1	0	9	1	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:120022237C>A	uc003ksq.2	+	2	911	c.748C>A	c.(748-750)CCC>ACC	p.P250T	PRR16_uc003ksp.2_Missense_Mutation_p.P227T|PRR16_uc003ksr.2_Missense_Mutation_p.P180T	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	250	Pro-rich.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		CCAAGGCCCTCCCCTCCCTCC	0.522													19	16					2.4624e-09	2.60446e-09	1	0	A	120022237	A	A	120022237	3	1	70	1	0	0	0	0	1	0	0	0	12651	855	30	2	685	2	PRR16	5	120022237	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	26162574	120022237	60893023	129	14283											
FBN2	2201	broad.mit.edu	37	chr5	127645021	127645021	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcagcacatcctttttgtCacattgaaaggcaactcatt	12	12	6	11	0	2	1	2	1	0	0	3	1	3	1	1	1	3	3	1	1	2	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:127645021C>G	uc003kuu.2	-	41	5710	c.5271G>C	c.(5269-5271)GTG>GTC	p.V1757V		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1757	TB 7.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCCTTTTTGTCACATTGAAAG	0.428													4	48					0	0	0	0	G	127645021	G	G	127645021	2	3	70	1	0	0	0	0	0	0	0	1	5735	813	29	2		2	FBN2	5	127645021	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	7622784	127645021	53270239	130	14284											
KDM3B	51780	broad.mit.edu	37	chr5	137735696	137735696	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctcaggaaaagccggccacGcagtggtaagtaaacattgt	13	7	12	9	2	1	0	1	0	0	0	1	1	1	1	2	3	2	4	2	3	5	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:137735696G>A	uc003lcy.1	+	11	3394	c.3194G>A	c.(3193-3195)CGC>CAC	p.R1065H	KDM3B_uc010jew.1_Missense_Mutation_p.R721H|KDM3B_uc011cys.1_Missense_Mutation_p.R97H	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1065					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AGCCGGCCACGCAGTGGTAAG	0.478													4	61					0	0	0	0	A	137735696	A	A	137735696	3	1	70	1	0	0	0	0	1	0	0	0	8166	1087	38	1	3236	1	KDM3B	5	137735696	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	10090675	137735696	43179564	131	14285											
PCDHB7	56129	broad.mit.edu	37	chr5	140554059	140554059	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcagcgaggcgctggtgcGcgtgctggtgctggacgcca	5	6	19	11	5	0	0	0	0	0	0	0	3	0	1	1	4	5	4	1	4	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:140554059G>A	uc003lit.2	+	1	1817	c.1643G>A	c.(1642-1644)CGC>CAC	p.R548H		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	548	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGCTGGTGCGCGTGCTGGTG	0.726													50	29					0	0	0	0	A	140554059	A	A	140554059	3	1	70	1	0	0	0	0	1	0	0	0	11601	1087	38	1	1645	1	PCDHB7	5	140554059	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2818363	140554059	40361201	132	14286											
PCDHGA4	56111	broad.mit.edu	37	chr5	140737171	140737171	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggatttacttgaaacaaaaGgagaccctaatcttcaggtg	15	10	9	7	0	2	2	1	1	1	1	2	4	2	3	1	3	2	0	1	3	5	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:140737171G>C	uc003ljq.1	+	1	2404	c.2404G>C	c.(2404-2406)GGA>CGA	p.G802R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGB2_uc003ljs.1_5'Flank|PCDHGA4_uc003ljp.1_Missense_Mutation_p.G802R|PCDHGB2_uc011dar.1_5'Flank	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	802	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAACAAAAGGAGACCCTAA	0.393													11	26					0	0	0	0	C	140737171	C	C	140737171	3	2	70	1	0	0	0	0	1	0	0	0	11610	1001	35	4	2406	4	PCDHGA4	5	140737171	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	183112	140737171	40178089	133	14287											
CYFIP2	26999	broad.mit.edu	37	chr5	156751060	156751060	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaaacagtccttcttcttCacacatctgctcaacatcag	12	11	3	15	0	6	0	3	0	3	0	7	0	7	0	1	0	3	1	1	0	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:156751060C>T	uc003lwq.2	+	18	1941	c.1803C>T	c.(1801-1803)TTC>TTT	p.F601F	CYFIP2_uc011ddn.1_Silent_p.F575F|CYFIP2_uc011ddo.1_Silent_p.F405F|CYFIP2_uc003lwr.2_Silent_p.F601F|CYFIP2_uc003lws.2_Silent_p.F601F|CYFIP2_uc003lwt.2_Silent_p.F504F|CYFIP2_uc011ddp.1_Silent_p.F335F	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	626					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTTCTTCTTCACACATCTGC	0.547													18	7					0	0	0	0	T	156751060	T	T	156751060	2	4	70	1	0	0	0	0	0	0	0	1	4155	825	29	2		2	CYFIP2	5	156751060	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	16013889	156751060	24164200	134	14288											
ATP10B	23120	broad.mit.edu	37	chr5	159992488	159992488	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgaactctgggatcggCgatggctgctcctctttgag	6	12	13	10	2	3	2	1	2	2	0	5	4	4	3	1	3	2	2	1	3	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:159992488C>T	uc003lym.1	-	26	5205	c.4358G>A	c.(4357-4359)CGC>CAC	p.R1453H	ATP10B_uc010jit.1_Missense_Mutation_p.R703H	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1453	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGGGATCGGCGATGGCTGCT	0.532													29	66					0	0	0	0	T	159992488	T	T	159992488	3	4	70	1	0	0	0	0	1	0	0	0	1119	768	27	1	31	1	ATP10B	5	159992488	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3241428	159992488	20922772	135	14289											
GABRG2	2566	broad.mit.edu	37	chr5	161569304	161569304	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggatcaataaggatgctgttCcagccagaacatctttaggt	12	11	10	8	0	2	1	1	0	1	1	3	3	3	3	2	3	3	2	2	3	4	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:161569304C>A	uc003lyz.3	+	7	1262	c.904C>A	c.(904-906)CCA>ACA	p.P302T	GABRG2_uc010jjc.2_Missense_Mutation_p.P342T|GABRG2_uc003lyy.3_Missense_Mutation_p.P302T|GABRG2_uc011dej.1_Missense_Mutation_p.P207T	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	302	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GGATGCTGTTCCAGCCAGAAC	0.403													64	22					7.59065e-32	8.31276e-32	1	0	A	161569304	A	A	161569304	3	1	70	1	0	0	0	0	1	0	0	0	6206	855	30	2	1054	2	GABRG2	5	161569304	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1576816	161569304	19345956	136	14290											
DOCK2	1794	broad.mit.edu	37	chr5	169454870	169454870	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctcctacatcttcagtttGaaaacgaaatcatcctgaag	13	12	6	10	1	4	2	2	2	2	0	6	3	5	2	2	0	2	1	2	0	5	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:169454870G>C	uc003maf.2	+	34	3465	c.3385G>C	c.(3385-3387)GAA>CAA	p.E1129Q	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.E621Q	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1129	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTTCAGTTTGAAAACGAAAT	0.393													15	43					0	0	0	0	C	169454870	C	C	169454870	3	2	70	1	0	0	0	0	1	0	0	0	4709	1291	45	2	3519	2	DOCK2	5	169454870	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	7885566	169454870	11460390	137	14291											
HIVEP1	3096	broad.mit.edu	37	chr6	12120396	12120396	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaataattgctgaagcctCaaaatctgaagaatctgtct	14	12	8	7	0	4	3	1	2	3	1	4	4	4	4	1	1	2	1	1	1	7	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:12120396C>G	uc003nac.2	+	4	547	c.368C>G	c.(367-369)TCA>TGA	p.S123*	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	123					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GCTGAAGCCTCAAAATCTGAA	0.433													25	54					0	0	0	0	G	12120396	G	G	12120396	4	3	70	1	0	0	0	0	0	1	0	0	7225	838	29	2	378	2	HIVEP1	6	12120396	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08		12120396	158994671	138	14292											
ACOT13	55856	broad.mit.edu	37	chr6	24698242	24698242	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gataacatatcaacaatggcTctgctatgcacggaaagggg	14	8	11	8	1	2	0	1	0	1	0	2	2	2	1	0	4	4	3	0	4	6	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:24698242T>C	uc003nek.2	+	2	442	c.213T>C	c.(211-213)GCT>GCC	p.A71A	ACOT13_uc010jpv.2_Silent_p.A48A	NM_018473	NP_060943	Q9NPJ3	ACO13_HUMAN	acyl-CoA thioesterase 13 isoform 1	71					protein homotetramerization	mitochondrion	acyl-CoA thioesterase activity				0						CAACAATGGCTCTGCTATGCA	0.438													15	41					0	0	0	0	C	24698242	C	C	24698242	2	2	70	1	0	0	0	0	0	0	0	1	151	1538	54	5		5	ACOT13	6	24698242	Silent	SNP	T	TCGA-CN-6011-01A-11D-1683-08	12577846	24698242	146416825	139	14293											
HIST1H3E	8353	broad.mit.edu	37	chr6	26225674	26225674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggcgctgcaggaggcctgcGaggcctacttggtggggctt	4	9	18	10	2	0	0	0	0	0	0	0	2	0	1	2	7	3	3	2	7	1	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:26225674G>A	uc003nhb.2	+	2	652	c.292G>A	c.(292-294)GAG>AAG	p.E98K	HIST1H3E_uc003nhc.3_Missense_Mutation_p.E98K	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				GGAGGCCTGCGAGGCCTACTT	0.592											OREG0017240	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	42					0	0	0	0	A	26225674	A	A	26225674	3	1	70	1	0	0	0	0	1	0	0	0	7198	1059	37	1	294	1	HIST1H3E	6	26225674	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1527432	26225674	144889393	140	14294											
HIST1H3H	8357	broad.mit.edu	37	chr6	27776351	27776351	+	5'Flank	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgctactgcccaagaagaccGagagccaccacaaggcgaag	14	3	11	13	2	0	3	0	0	0	3	0	5	0	3	4	1	4	1	4	1	5	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:27776351G>C	uc003njm.2	+						HIST1H2BL_uc003njl.2_5'Flank	NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h						blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						CAAGAAGACCGAGAGCCACCA	0.542													24	20					0	0	0	0	C	27776351	C	C	27776351	1	2	70	0	1	0	0	0	0	0	0	0	7201	1059	37	3		3	HIST1H3H	6	27776351	5'Flank	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1550677	27776351	143338716	141	14295											
GABBR1	2550	broad.mit.edu	37	chr6	29588923	29588923	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaggattcagcatgacaatCtcagttgtgatgtggccctc	9	11	11	10	0	2	2	2	2	1	0	4	3	2	3	1	2	1	3	1	2	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:29588923C>G	uc003nmt.3	-	11	1614	c.1278G>C	c.(1276-1278)GAG>GAC	p.E426D	GABBR1_uc003nmp.3_Missense_Mutation_p.E309D|GABBR1_uc003nms.3_Missense_Mutation_p.E309D|GABBR1_uc003nmu.3_Missense_Mutation_p.E364D|GABBR1_uc011dlr.1_Missense_Mutation_p.E249D|GABBR1_uc011dls.1_Missense_Mutation_p.E426D	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	426	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	GCATGACAATCTCAGTTGTGA	0.532													11	28					0	0	0	0	G	29588923	G	G	29588923	3	3	70	1	0	0	0	0	1	0	0	0	6189	912	32	2	1659	2	GABBR1	6	29588923	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1812572	29588923	141526144	142	14296											
VARS	7407	broad.mit.edu	37	chr6	31750118	31750118	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgggcctcaggcaggatgcgGaggtcaccccgagtcacagc	8	5	15	13	2	3	0	3	0	0	0	3	3	3	2	3	5	2	1	3	5	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:31750118G>C	uc003nxe.2	-	17	2517	c.2094C>G	c.(2092-2094)CTC>CTG	p.L698L	VARS_uc003nxf.1_5'Flank|VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	698					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GCAGGATGCGGAGGTCACCCC	0.667													6	15					0	0	0	0	C	31750118	C	C	31750118	2	2	70	1	0	0	0	0	0	0	0	1	17191	1161	41	2		2	VARS	6	31750118	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2161195	31750118	139364949	143	14297											
VARS	7407	broad.mit.edu	37	chr6	31759748	31759748	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcatggggccactgacaTctgggggagaggaagggagg	9	4	21	7	1	1	2	0	1	1	1	1	5	1	4	1	8	0	1	1	8	1	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:31759748T>G	uc003nxe.2	-	7	1295	c.872A>C	c.(871-873)GAT>GCT	p.D291A	VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	291					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GCCACTGACATCTGGGGGAGA	0.622													3	6					0	0	0	0	G	31759748	G	G	31759748	3	3	70	1	0	0	0	0	1	0	0	0	17191	1449	50	5	3018	5	VARS	6	31759748	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	9630	31759748	139355319	144	14298											
ATF6B	1388	broad.mit.edu	37	chr6	32087660	32087660	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaacgatgctcttcctctCaggccgtggtagagagggag	8	8	16	9	2	2	1	1	0	2	1	4	5	3	3	2	4	2	2	2	4	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:32087660C>T	uc003nzn.2	-	9	940	c.907G>A	c.(907-909)GAG>AAG	p.E303K	TNXB_uc010jts.1_5'Flank|ATF6B_uc003nzm.1_5'Flank|ATF6B_uc003nzo.2_Missense_Mutation_p.E300K|ATF6B_uc003nzp.1_5'UTR	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	303	Cytoplasmic (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTCTTCCTCTCAGGCCGTGGT	0.592													13	33					0	0	0	0	T	32087660	T	T	32087660	3	4	70	1	0	0	0	0	1	0	0	0	1087	835	29	2	1244	2	ATF6B	6	32087660	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	327912	32087660	139027407	145	14299											
DNAH8	1769	broad.mit.edu	37	chr6	38830055	38830055	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttattggatgaacatttgcaGatgctatatcacgttagctc	11	15	8	7	1	1	2	1	1	0	1	2	3	1	3	0	1	4	4	0	1	5	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:38830055G>A	uc003ooe.1	+	42	6081	c.5481_splice	c.e42-1	p.R1827_splice		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AACATTTGCAGATGCTATATC	0.463													18	34					0	0	0	0	A	38830055	A	A	38830055	5	1	70	1	0	0	0	0	0	0	1	0	4629	956	33	2	5638	2	DNAH8	6	38830055	Splice_Site	SNP	G	TCGA-CN-6011-01A-11D-1683-08	6742395	38830055	132285012	146	14300											
KIF6	221458	broad.mit.edu	37	chr6	39688494	39688494	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttacttaaatttgtagctttCtcgcttattattcacaaacc	11	18	3	9	1	2	0	1	0	1	0	3	0	2	0	1	0	3	3	1	0	7	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:39688494C>T	uc003oot.2	-	2	255	c.160G>A	c.(160-162)GAA>AAA	p.E54K	KIF6_uc011dua.1_Missense_Mutation_p.E54K|KIF6_uc010jxb.1_Missense_Mutation_p.E54K	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	54	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TTGTAGCTTTCTCGCTTATTA	0.299													15	25					0	0	0	0	T	39688494	T	T	39688494	3	4	70	1	0	0	0	0	1	0	0	0	8347	922	32	2	2372	2	KIF6	6	39688494	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	858439	39688494	131426573	147	14301											
SRF	6722	broad.mit.edu	37	chr6	43144380	43144380	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtgacagcagcacagacctCacgcagacctcctccagcgg	10	4	10	17	3	1	3	1	1	0	2	3	3	3	3	4	1	3	3	4	1	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:43144380C>T	uc003oui.2	+	4	1612	c.1137C>T	c.(1135-1137)CTC>CTT	p.L379L	SRF_uc011dvf.1_Silent_p.L175L	NM_003131	NP_003122	P11831	SRF_HUMAN	serum response factor (c-fos serum response	379					angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|transcription from RNA polymerase II promoter|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			ovary(1)|breast(1)|central_nervous_system(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GCACAGACCTCACGCAGACCT	0.647													18	81					0	0	0	0	T	43144380	T	T	43144380	2	4	70	1	0	0	0	0	0	0	0	1	15209	813	29	2		2	SRF	6	43144380	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3455886	43144380	127970687	148	14302											
MICAL1	64780	broad.mit.edu	37	chr6	109771220	109771220	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgccctctgcccaccgcttCaccatccaggctgcatcaaa	8	7	7	19	2	3	0	2	0	1	0	4	0	4	0	5	1	2	3	5	1	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:109771220C>T	uc003ptj.2	-	8	1514	c.1260G>A	c.(1258-1260)GTG>GTA	p.V420V	MICAL1_uc003ptk.2_Silent_p.V420V|MICAL1_uc010kdr.2_Silent_p.V334V|MICAL1_uc011eaq.1_Silent_p.V439V	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	420					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CCCACCGCTTCACCATCCAGG	0.612													25	251					0	0	0	0	T	109771220	T	T	109771220	2	4	70	1	0	0	0	0	0	0	0	1	9622	813	29	2		2	MICAL1	6	109771220	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	66626840	109771220	61343847	149	14303											
LAMA4	3910	broad.mit.edu	37	chr6	112443245	112443245	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaatctccttttaagtgttCaaactcttggcggctgttgg	9	15	9	8	1	3	0	1	0	2	0	4	0	3	0	1	3	1	3	1	3	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:112443245C>G	uc003pvu.2	-	32	4756	c.4447G>C	c.(4447-4449)GAA>CAA	p.E1483Q	LAMA4_uc003pvv.2_Missense_Mutation_p.E1476Q|LAMA4_uc003pvt.2_Missense_Mutation_p.E1476Q	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1483	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTTAAGTGTTCAAACTCTTGG	0.443													17	54					0	0	0	0	G	112443245	G	G	112443245	3	3	70	1	0	0	0	0	1	0	0	0	8648	835	29	2	1056	2	LAMA4	6	112443245	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2672025	112443245	58671822	150	14304											
RSPH4A	345895	broad.mit.edu	37	chr6	116938128	116938128	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cctcagtcggacaggaccacGagtgtgattcctgaagctgg	9	8	13	11	2	1	2	1	2	0	0	3	5	2	4	3	3	1	1	3	3	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:116938128G>C	uc003pxe.2	+	1	487	c.342G>C	c.(340-342)ACG>ACC	p.T114T	RSPH4A_uc010kee.2_Silent_p.T114T	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	114					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						ACAGGACCACGAGTGTGATTC	0.552									Kartagener_syndrome				18	51					0	0	0	0	C	116938128	C	C	116938128	2	2	70	1	0	0	0	0	0	0	0	1	13771	1045	37	3		3	RSPH4A	6	116938128	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	4494883	116938128	54176939	151	14305											
FAM184A	79632	broad.mit.edu	37	chr6	119345734	119345734	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagttgcatgtcctcaactCtgtgcttataagcttcaaat	12	14	6	9	0	3	0	2	0	1	0	4	0	4	0	1	0	4	4	1	0	5	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:119345734C>G	uc003pyj.2	-	2	752	c.404G>C	c.(403-405)AGA>ACA	p.R135T	FAM184A_uc003pyk.3_Missense_Mutation_p.R15T|FAM184A_uc003pyl.3_Missense_Mutation_p.R15T	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	135	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						GTCCTCAACTCTGTGCTTATA	0.378													25	42					0	0	0	0	G	119345734	G	G	119345734	3	3	70	1	0	0	0	0	1	0	0	0	5539	913	32	2	3086	2	FAM184A	6	119345734	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2407606	119345734	51769333	152	14306											
STX7	8417	broad.mit.edu	37	chr6	132785161	132785161	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgcccttgacagctgctGatttgcttgctgaacgtgca	6	13	11	11	1	0	3	0	3	0	0	0	3	0	3	1	0	8	6	1	0	1	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:132785161G>A	uc003qdg.2	-	9	914	c.664C>T	c.(664-666)CAG>TAG	p.Q222*	STX7_uc011ecg.1_RNA|STX7_uc011ech.1_Nonsense_Mutation_p.Q47*	NM_003569	NP_003560	O15400	STX7_HUMAN	syntaxin 7	222	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity				0	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		GACAGCTGCTGATTTGCTTGC	0.378													30	101					0	0	0	0	A	132785161	A	A	132785161	4	1	70	1	0	0	0	0	0	1	0	0	15416	1299	45	2	129	2	STX7	6	132785161	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	13439427	132785161	38329906	153	14307											
TAAR6	319100	broad.mit.edu	37	chr6	132892295	132892295	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taccatatagcattgattcaTtaattgatgcctttatgggc	11	16	7	7	0	1	2	1	2	0	0	1	2	1	2	2	1	3	1	2	1	5	9			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:132892295T>C	uc011eck.1	+	1	835	c.835T>C	c.(835-837)TTA>CTA	p.L279L		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	279	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		CATTGATTCATTAATTGATGC	0.408													22	61					0	0	0	0	C	132892295	C	C	132892295	2	2	70	1	0	0	0	0	0	0	0	1	15558	1490	52	5		5	TAAR6	6	132892295	Silent	SNP	T	TCGA-CN-6011-01A-11D-1683-08	107134	132892295	38222772	154	14308											
CCDC28A	25901	broad.mit.edu	37	chr6	139106386	139106386	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgaatgttccattgaacaGatggaacatgttcggggaat	14	11	11	5	1	0	3	0	2	0	1	2	5	1	5	1	3	2	2	1	3	5	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:139106386G>A	uc003qie.2	+	4	770	c.615G>A	c.(613-615)CAG>CAA	p.Q205Q		NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	205											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		CCATTGAACAGATGGAACATG	0.388													53	45					0	0	0	0	A	139106386	A	A	139106386	2	1	70	1	0	0	0	0	0	0	0	1	2815	933	33	2		2	CCDC28A	6	139106386	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	6214091	139106386	32008681	155	14309											
C6orf115	58527	broad.mit.edu	37	chr6	139363855	139363855	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caatgtattttctcaaactaGatgctgatggaaagttaagc	14	13	8	6	0	1	2	1	1	1	1	2	3	1	3	0	1	3	3	0	1	6	5	rs9495322		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:139363855G>C	uc003qil.2	+	3	262	c.62_splice	c.e3-1	p.N21_splice	C6orf115_uc003qim.2_Splice_Site_p.N21_splice	NM_021243	NP_067066	Q9P1F3	CF115_HUMAN	hypothetical protein LOC58527												0				GBM - Glioblastoma multiforme(68;0.000278)|OV - Ovarian serous cystadenocarcinoma(155;0.000413)		TCTCAAACTAGATGCTGATGG	0.358													37	117					0	0	0	0	C	139363855	C	C	139363855	5	2	70	1	0	0	0	0	0	0	1	0	2332	956	33	2	67	2	C6orf115	6	139363855	Splice_Site	SNP	G	TCGA-CN-6011-01A-11D-1683-08	257469	139363855	31751212	156	14310											
GPR126	57211	broad.mit.edu	37	chr6	142718791	142718791	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtttacaatgctaccaacaAtactaatttggaaggaaaaa	19	10	6	6	0	0	0	0	0	0	0	0	2	0	2	1	2	5	2	1	2	10	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:142718791A>G	uc010khc.2	+	10	1877	c.1466A>G	c.(1465-1467)AAT>AGT	p.N489S	GPR126_uc010khd.2_Missense_Mutation_p.N461S|GPR126_uc010khe.2_Missense_Mutation_p.N489S|GPR126_uc010khf.2_Missense_Mutation_p.N461S	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	489	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		GCTACCAACAATACTAATTTG	0.398													29	23					0	0	0	0	G	142718791	G	G	142718791	3	3	70	1	0	0	0	0	1	0	0	0	6678	101	4	5	1504	5	GPR126	6	142718791	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08	3354936	142718791	28396276	157	14311											
HIVEP2	3097	broad.mit.edu	37	chr6	143094723	143094723	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcgggctcagaaggttgaGcgatggctcagaatcttgtc	8	10	15	8	2	3	3	2	1	1	2	4	4	3	3	0	3	2	3	0	3	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:143094723G>C	uc003qjd.2	-	5	1896	c.1153C>G	c.(1153-1155)CTC>GTC	p.L385V		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AGAAGGTTGAGCGATGGCTCA	0.438													43	103					0	0	0	0	C	143094723	C	C	143094723	3	2	70	1	0	0	0	0	1	0	0	0	7226	971	34	4	6211	4	HIVEP2	6	143094723	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	375932	143094723	28020344	158	14312											
SYNE1	23345	broad.mit.edu	37	chr6	152720763	152720763	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaactcaccactgaagtgttTttccagagattcctgcaggc	10	11	9	11	0	1	2	1	1	0	1	3	4	3	2	3	1	2	2	3	1	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:152720763T>A	uc010kiw.2	-	48	7827	c.7225A>T	c.(7225-7227)AAA>TAA	p.K2409*	SYNE1_uc003qot.3_Nonsense_Mutation_p.K2416*|SYNE1_uc003qou.3_Nonsense_Mutation_p.K2409*|SYNE1_uc010kjb.1_Nonsense_Mutation_p.K2392*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2409	Spectrin 4.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGAAGTGTTTTTCCAGAGAT	0.493										HNSCC(10;0.0054)			138	142					0	0	0	0	A	152720763	A	A	152720763	4	1	70	1	0	0	0	0	0	1	0	0	15511	1850	64	5	19637	5	SYNE1	6	152720763	Nonsense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	9626040	152720763	18394304	159	14313											
SYNE1	23345	broad.mit.edu	37	chr6	152763259	152763259	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgctccaggccatccagtGtgctctccagcttccgcagc	5	9	10	17	2	1	0	0	0	1	0	5	0	4	0	5	1	4	4	5	1	0	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:152763259G>T	uc010kiw.2	-	31	4561	c.3959C>A	c.(3958-3960)ACA>AAA	p.T1320K	SYNE1_uc003qot.3_Missense_Mutation_p.T1327K|SYNE1_uc003qou.3_Missense_Mutation_p.T1320K|SYNE1_uc010kjb.1_Missense_Mutation_p.T1303K|SYNE1_uc003qow.2_Missense_Mutation_p.T615K|SYNE1_uc003qox.1_Missense_Mutation_p.T836K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1320	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCCATCCAGTGTGCTCTCCAG	0.637										HNSCC(10;0.0054)			17	53					3.6726e-16	3.98671e-16	1	0	T	152763259	T	T	152763259	3	4	70	1	0	0	0	0	1	0	0	0	15511	1377	48	4	22971	4	SYNE1	6	152763259	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	42496	152763259	18351808	160	14314											
SYNE1	23345	broad.mit.edu	37	chr6	152841605	152841605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctcttacctttcttccttCgaggaacttgagtgccgtgc	5	15	8	13	2	2	1	0	1	2	0	5	3	3	2	3	1	4	0	3	1	2	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:152841605C>T	uc010kiw.2	-	6	900	c.298G>A	c.(298-300)GAA>AAA	p.E100K	SYNE1_uc003qot.3_Missense_Mutation_p.E100K|SYNE1_uc003qou.3_Missense_Mutation_p.E100K|SYNE1_uc010kjb.1_Missense_Mutation_p.E100K|SYNE1_uc003qpa.1_Missense_Mutation_p.E100K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	100	Actin-binding.|Cytoplasmic (Potential).|CH 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTCTTCCTTCGAGGAACTTG	0.443										HNSCC(10;0.0054)			40	137					0	0	0	0	T	152841605	T	T	152841605	3	4	70	1	0	0	0	0	1	0	0	0	15511	893	31	1	26757	1	SYNE1	6	152841605	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	78346	152841605	18273462	161	14315											
FNDC1	84624	broad.mit.edu	37	chr6	159653679	159653679	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgcagaggaagattccagtgCctcagccccaccctcaagac	11	5	9	16	1	2	3	2	0	0	3	3	4	3	4	5	1	2	1	5	1	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:159653679C>T	uc010kjv.2	+	11	2335	c.2135C>T	c.(2134-2136)GCC>GTC	p.A712V	FNDC1_uc010kjw.1_Missense_Mutation_p.A597V	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	712	Ser-rich.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GATTCCAGTGCCTCAGCCCCA	0.657													8	12					0	0	0	0	T	159653679	T	T	159653679	3	4	70	1	0	0	0	0	1	0	0	0	6000	739	26	4	2177	4	FNDC1	6	159653679	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	6812074	159653679	11461388	162	14316											
SLC22A3	6581	broad.mit.edu	37	chr6	160857877	160857877	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtgagaactccccaaatGaggaaatgcacacttattct	13	10	8	10	0	1	2	0	2	1	1	2	4	2	3	2	2	2	1	2	2	4	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:160857877G>C	uc003qti.2	+	6	1068	c.1041G>C	c.(1039-1041)ATG>ATC	p.M347I	SLC22A3_uc011efx.1_Intron	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	347						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		CTCCCCAAATGAGGAAATGCA	0.348													16	33					0	0	0	0	C	160857877	C	C	160857877	3	2	70	1	0	0	0	0	1	0	0	0	14519	1290	45	2	1063	2	SLC22A3	6	160857877	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1204198	160857877	10257190	163	14317											
SLC22A3	6581	broad.mit.edu	37	chr6	160864770	160864770	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctagaactacctctgatcatCtttggtaagaactcatttgc	11	14	6	10	0	4	3	2	1	2	2	4	3	4	3	1	1	4	1	1	1	5	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:160864770C>T	uc003qti.2	+	9	1533	c.1506C>T	c.(1504-1506)ATC>ATT	p.I502I	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	502	Helical; (Potential).					integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		CTCTGATCATCTTTGGTAAGA	0.393													32	21					0	0	0	0	T	160864770	T	T	160864770	2	4	70	1	0	0	0	0	0	0	0	1	14519	903	32	2		2	SLC22A3	6	160864770	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	6893	160864770	10250297	164	14318											
THBS2	7058	broad.mit.edu	37	chr6	169640633	169640633	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccagcaagctgacatgtTccttgtcttaggagggccac	8	10	11	12	0	1	1	0	1	1	0	2	2	2	2	3	2	3	3	3	2	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:169640633T>G	uc003qwt.2	-	7	1194	c.946A>C	c.(946-948)AAC>CAC	p.N316H		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	316					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GCTGACATGTTCCTTGTCTTA	0.483													27	24					0	0	0	0	G	169640633	G	G	169640633	3	3	70	1	0	0	0	0	1	0	0	0	15920	1783	62	5	2640	5	THBS2	6	169640633	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	8775863	169640633	1474434	165	14319											
ETV1	2115	broad.mit.edu	37	chr7	13946217	13946217	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacattcctggctcttgtttGatgtctcctaaattaaaaca	11	16	5	9	0	2	1	0	1	2	0	4	1	3	1	2	1	2	2	2	1	5	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:13946217G>C	uc011jxq.1	-	12	1687	c.948C>G	c.(946-948)ATC>ATG	p.I316M	ETV1_uc011jxn.1_Missense_Mutation_p.I276M|ETV1_uc011jxo.1_Missense_Mutation_p.I213M|ETV1_uc011jxp.1_Missense_Mutation_p.I258M|ETV1_uc003ssw.3_Missense_Mutation_p.I293M|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.I298M|ETV1_uc011jxs.1_Missense_Mutation_p.I298M|ETV1_uc010ktv.2_Nonsense_Mutation_p.S185*	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	316					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						GCTCTTGTTTGATGTCTCCTA	0.368			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								3	11					0	0	0	0	C	13946217	C	C	13946217	3	2	70	1	0	0	0	0	1	0	0	0	5301	1280	45	2	497	2	ETV1	7	13946217	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08		13946217	145192446	166	14320											
AGR3	155465	broad.mit.edu	37	chr7	16902261	16902261	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtattgacaatcctccaggtGatgaataaccattaatggct	13	12	8	8	0	0	3	0	3	0	0	2	3	2	3	3	2	1	2	3	2	5	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:16902261G>A	uc003sts.2	-	4	272	c.199C>T	c.(199-201)CAC>TAC	p.H67Y		NM_176813	NP_789783	Q8TD06	AGR3_HUMAN	breast cancer membrane protein 11 precursor	67						extracellular region					0	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		TCCTCCAGGTGATGAATAACC	0.284													17	86					0	0	0	0	A	16902261	A	A	16902261	3	1	70	1	0	0	0	0	1	0	0	0	396	1290	45	2	321	2	AGR3	7	16902261	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2956044	16902261	142236402	167	14321											
ABCB5	340273	broad.mit.edu	37	chr7	20762686	20762686	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acacaaaatgcaactaacatGggactttcagttatcatttc	15	12	5	9	0	2	0	2	0	0	0	3	1	2	1	0	1	3	2	0	1	5	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:20762686G>T	uc003suw.3	+	12	1680	c.1134G>T	c.(1132-1134)ATG>ATT	p.M378I	ABCB5_uc010kuh.2_Missense_Mutation_p.M823I|ABCB5_uc003sux.1_Missense_Mutation_p.M1I	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	378	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CAACTAACATGGGACTTTCAG	0.378													37	77					5.71845e-15	6.18042e-15	1	0	T	20762686	T	T	20762686	3	4	70	1	0	0	0	0	1	0	0	0	44	1348	47	4	2588	4	ABCB5	7	20762686	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3860425	20762686	138375977	168	14322											
DNAH11	8701	broad.mit.edu	37	chr7	21599363	21599363	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtctcctcaagcagaactaGatttctggatgatgaggaga	12	11	11	7	0	3	5	1	2	2	3	4	7	3	6	1	2	2	1	1	2	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:21599363G>C	uc003svc.2	+	4	866	c.835G>C	c.(835-837)GAT>CAT	p.D279H		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	279	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGCAGAACTAGATTTCTGGAT	0.358									Kartagener_syndrome				7	8					0	0	0	0	C	21599363	C	C	21599363	3	2	70	1	0	0	0	0	1	0	0	0	4621	942	33	2	849	2	DNAH11	7	21599363	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	836677	21599363	137539300	169	14323											
BBS9	27241	broad.mit.edu	37	chr7	33388766	33388766	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaattgacttgtgatcagttCacctttgaatttatgagtaa	12	16	8	5	0	2	4	2	4	0	0	2	5	2	4	1	0	0	2	1	0	4	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:33388766C>T	uc003tdn.1	+	13	1929	c.1416C>T	c.(1414-1416)TTC>TTT	p.F472F	BBS9_uc003tdo.1_Silent_p.F472F|BBS9_uc003tdp.1_Silent_p.F472F|BBS9_uc003tdq.1_Silent_p.F472F|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_5'UTR|BBS9_uc003tds.1_5'Flank|BBS9_uc011kao.1_Silent_p.F350F	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	472					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GTGATCAGTTCACCTTTGAAT	0.333									Bardet-Biedl_syndrome				14	76					0	0	0	0	T	33388766	T	T	33388766	2	4	70	1	0	0	0	0	0	0	0	1	1344	825	29	2		2	BBS9	7	33388766	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	11789403	33388766	125749897	170	14324											
BMPER	168667	broad.mit.edu	37	chr7	34118611	34118611	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttccaggtgctggtgaagaaCgacgcccgccggacacgctc	8	6	13	14	5	0	2	0	1	0	1	2	4	1	3	3	3	2	2	3	3	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:34118611C>G	uc011kap.1	+	12	1335	c.1221C>G	c.(1219-1221)AAC>AAG	p.N407K		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	407	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						TGGTGAAGAACGACGCCCGCC	0.607													49	88					0	0	0	0	G	34118611	G	G	34118611	3	3	70	1	0	0	0	0	1	0	0	0	1471	535	19	3	1267	3	BMPER	7	34118611	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	729845	34118611	125020052	171	14325											
VPS41	27072	broad.mit.edu	37	chr7	38812139	38812139	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacttcatatttcttcttttCaaggagccagtcaatgtgat	10	17	6	8	0	5	1	3	1	2	0	5	2	5	2	1	1	2	0	1	1	4	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:38812139C>G	uc003tgy.2	-	13	1137	c.1111G>C	c.(1111-1113)GAA>CAA	p.E371Q	VPS41_uc003tgz.2_Missense_Mutation_p.E346Q|VPS41_uc010kxn.2_Missense_Mutation_p.E282Q	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	371					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TTCTTCTTTTCAAGGAGCCAG	0.363													9	40					0	0	0	0	G	38812139	G	G	38812139	3	3	70	1	0	0	0	0	1	0	0	0	17278	835	29	2	1521	2	VPS41	7	38812139	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	4693528	38812139	120326524	172	14326											
TNS3	64759	broad.mit.edu	37	chr7	47319949	47319949	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtaatgcctccggaagaaGagcctgttgggacatggggg	9	7	18	7	1	0	2	0	0	0	2	1	4	1	4	3	5	2	2	3	5	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:47319949G>C	uc003tnv.2	-	29	4468	c.4101C>G	c.(4099-4101)CTC>CTG	p.L1367L	TNS3_uc003tnw.2_Silent_p.L1367L	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	1367						focal adhesion	protein binding			ovary(4)	4						TCCGGAAGAAGAGCCTGTTGG	0.502													8	37					0	0	0	0	C	47319949	C	C	47319949	2	2	70	1	0	0	0	0	0	0	0	1	16410	929	33	2		2	TNS3	7	47319949	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	8507810	47319949	111818714	173	14327											
IKZF1	10320	broad.mit.edu	37	chr7	50450284	50450284	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcggggcctcattcacccaGaagggcaacctgctccggca	8	6	12	15	2	2	1	2	0	0	1	3	1	3	1	4	4	3	3	4	4	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:50450284G>A	uc003tow.3	+	6	636	c.468G>A	c.(466-468)CAG>CAA	p.Q156Q	IKZF1_uc003tox.3_Silent_p.Q156Q|IKZF1_uc003toy.3_Silent_p.Q156Q|IKZF1_uc011kck.1_Silent_p.Q69Q|IKZF1_uc003toz.3_Silent_p.Q126Q|IKZF1_uc010kyx.2_Intron	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	156	Required for both high-affinity DNA binding and pericentromeric heterochromatin localization (By similarity).|C2H2-type 2.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(74)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CATTCACCCAGAAGGGCAACC	0.612			D		ALL								5	25					0	0	0	0	A	50450284	A	A	50450284	2	1	70	1	0	0	0	0	0	0	0	1	7653	933	33	2		2	IKZF1	7	50450284	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3130335	50450284	108688379	174	14328											
COBL	23242	broad.mit.edu	37	chr7	51261114	51261114	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaggcttaaccttctcttCaggaactttttctttcagaa	10	15	5	11	0	4	1	2	0	2	1	5	2	4	2	2	2	2	1	2	2	3	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:51261114C>T	uc003tpr.3	-	3	603	c.418G>A	c.(418-420)GAA>AAA	p.E140K	COBL_uc003tps.2_Missense_Mutation_p.E140K|COBL_uc011kcl.1_Missense_Mutation_p.E140K|COBL_uc010kzc.2_Missense_Mutation_p.E140K|COBL_uc003tpt.2_Missense_Mutation_p.E140K|COBL_uc003tpp.3_5'Flank|COBL_uc003tpq.3_Missense_Mutation_p.E56K	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	140										skin(3)|ovary(2)	5	Glioma(55;0.08)					ACCTTCTCTTCAGGAACTTTT	0.453													14	77					0	0	0	0	T	51261114	T	T	51261114	3	4	70	1	0	0	0	0	1	0	0	0	3668	835	29	2	3411	2	COBL	7	51261114	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	810830	51261114	107877549	175	14329											
AUTS2	26053	broad.mit.edu	37	chr7	70252204	70252204	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccatttcagcacccaactCaatgttcggccacaaggatg	12	8	7	14	1	2	0	2	0	0	0	3	1	2	1	3	2	2	2	3	2	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:70252204C>G	uc003tvw.3	+	18	3061	c.2318C>G	c.(2317-2319)TCA>TGA	p.S773*	AUTS2_uc003tvx.3_Nonsense_Mutation_p.S749*|AUTS2_uc011keg.1_Nonsense_Mutation_p.S225*	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	773										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GCACCCAACTCAATGTTCGGC	0.473													7	21					0	0	0	0	G	70252204	G	G	70252204	4	3	70	1	0	0	0	0	0	1	0	0	1227	838	29	2	2533	2	AUTS2	7	70252204	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	18991090	70252204	88886459	176	14330											
SEMA3A	10371	broad.mit.edu	37	chr7	83610791	83610791	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgttgaaccaatatatagttGttgctgtggaaagagtttac	12	14	10	5	1	0	2	0	1	0	1	0	3	0	3	1	1	3	5	1	1	7	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:83610791G>T	uc003uhz.2	-	14	1813	c.1498C>A	c.(1498-1500)CAA>AAA	p.Q500K		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	500	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ATATATAGTTGTTGCTGTGGA	0.418													4	9					2.56e-06	2.67907e-06	1	0	T	83610791	T	T	83610791	3	4	70	1	0	0	0	0	1	0	0	0	14089	1386	48	4	833	4	SEMA3A	7	83610791	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	13358587	83610791	75527872	177	14331											
MTERF	7978	broad.mit.edu	37	chr7	91503289	91503289	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagctcctggaccacatatCagaaccagcagttcctcact	11	9	6	15	0	3	1	3	0	0	1	5	2	5	2	4	1	3	3	4	1	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:91503289C>G	uc003ulb.1	-	2	863	c.819G>C	c.(817-819)CTG>CTC	p.L273L	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Silent_p.L273L|MTERF_uc011khm.1_Silent_p.L253L|MTERF_uc010leu.1_Silent_p.L253L	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	273					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			GACCACATATCAGAACCAGCA	0.413													10	46					0	0	0	0	G	91503289	G	G	91503289	2	3	70	1	0	0	0	0	0	0	0	1	9971	813	29	2		2	MTERF	7	91503289	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	7892498	91503289	67635374	178	14332											
CALCR	799	broad.mit.edu	37	chr7	93098029	93098029	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgtgagtgtacttacctGaaaaacacgaaaatccccag	14	9	8	10	1	0	2	0	2	0	0	1	3	1	2	3	0	4	2	3	0	6	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:93098029G>A	uc003umv.1	-	7	834	c.573C>T	c.(571-573)TTC>TTT	p.F191F	CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Silent_p.F173F|CALCR_uc003umw.2_Silent_p.F173F	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	173	Helical; Name=1; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GTACTTACCTGAAAAACACGA	0.418													6	38					0	0	0	0	A	93098029	A	A	93098029	2	1	70	1	0	0	0	0	0	0	0	1	2591	1281	45	2		2	CALCR	7	93098029	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1594740	93098029	66040634	179	14333											
COL1A2	1278	broad.mit.edu	37	chr7	94052411	94052411	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgctggtgagaagggtccctCtggagaggctggtactgctg	6	9	17	9	1	1	2	0	1	1	2	2	4	2	2	1	5	2	4	1	5	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:94052411C>T	uc003ung.1	+	40	3017	c.2546C>T	c.(2545-2547)TCT>TTT	p.S849F	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	849			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AAGGGTCCCTCTGGAGAGGCT	0.507										HNSCC(75;0.22)			15	91					0	0	0	0	T	94052411	T	T	94052411	3	4	70	1	0	0	0	0	1	0	0	0	3693	913	32	2	2704	2	COL1A2	7	94052411	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	954382	94052411	65086252	180	14334											
C7orf43	55262	broad.mit.edu	37	chr7	99753354	99753354	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggtgagcgcgctgcccttCcgggaaaagccaaggttgtt	9	8	14	10	3	0	1	0	1	0	0	1	2	1	2	3	3	3	3	3	3	4	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:99753354C>T	uc003utr.2	-	9	1515	c.1335G>A	c.(1333-1335)CGG>CGA	p.R445R	C7orf43_uc010lgo.2_Silent_p.R71R|C7orf43_uc010lgp.2_Silent_p.R67R|C7orf43_uc011kjj.1_Silent_p.R213R|C7orf43_uc003uts.2_Silent_p.R176R	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	445											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGCTGCCCTTCCGGGAAAAGC	0.657													30	120					0	0	0	0	T	99753354	T	T	99753354	2	4	70	1	0	0	0	0	0	0	0	1	2404	842	30	2		2	C7orf43	7	99753354	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	5700943	99753354	59385309	181	14335											
PSMC2	5701	broad.mit.edu	37	chr7	103006550	103006550	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatggttcgtgaactctttGaaatggccagaacaaaaaaa	17	9	9	6	1	1	3	0	2	1	1	2	4	1	3	1	2	2	1	1	2	7	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:103006550G>C	uc003vbs.2	+	9	854	c.784G>C	c.(784-786)GAA>CAA	p.E262Q	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.E125Q	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	262					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TGAACTCTTTGAAATGGCCAG	0.323													40	51					0	0	0	0	C	103006550	C	C	103006550	3	2	70	1	0	0	0	0	1	0	0	0	12748	1291	45	2	818	2	PSMC2	7	103006550	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3253196	103006550	56132113	182	14336											
RELN	5649	broad.mit.edu	37	chr7	103155675	103155675	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgtcaaaggcgatcctcccGacagggccggcatctgcagg	9	6	13	13	3	2	0	1	0	1	0	4	2	4	0	3	4	1	2	3	4	1	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:103155675G>A	uc003vca.2	-	50	8236	c.8076C>T	c.(8074-8076)GTC>GTT	p.V2692V	RELN_uc010liz.2_Silent_p.V2692V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2692					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CGATCCTCCCGACAGGGCCGG	0.517													6	39					0	0	0	0	A	103155675	A	A	103155675	2	1	70	1	0	0	0	0	0	0	0	1	13285	1045	37	1		1	RELN	7	103155675	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	149125	103155675	55982988	183	14337											
EXOC4	60412	broad.mit.edu	37	chr7	133059592	133059592	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgccactaggttgcttctaGaactgctggagttactgttt	8	15	10	8	0	1	1	0	0	1	1	1	2	1	2	1	2	5	5	1	2	4	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:133059592G>A	uc003vrk.2	+	7	1053	c.1018G>A	c.(1018-1020)GAA>AAA	p.E340K	EXOC4_uc011kpo.1_Missense_Mutation_p.E239K|EXOC4_uc003vri.2_Missense_Mutation_p.E340K|EXOC4_uc003vrj.2_Missense_Mutation_p.E340K	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	340					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				GTTGCTTCTAGAACTGCTGGA	0.423													17	39					0	0	0	0	A	133059592	A	A	133059592	3	1	70	1	0	0	0	0	1	0	0	0	5330	943	33	2	1044	2	EXOC4	7	133059592	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	29903917	133059592	26079071	184	14338											
ZC3HAV1	56829	broad.mit.edu	37	chr7	138764323	138764323	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctaggtgatgatatttctCtgtgaccgctgctagtgctt	6	16	10	9	1	1	3	0	3	1	0	3	3	2	3	2	1	2	3	2	1	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:138764323C>G	uc003vun.2	-	4	1752	c.1364G>C	c.(1363-1365)AGA>ACA	p.R455T	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Missense_Mutation_p.R455T	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	455					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						TGATATTTCTCTGTGACCGCT	0.468													24	41					0	0	0	0	G	138764323	G	G	138764323	3	3	70	1	0	0	0	0	1	0	0	0	17642	913	32	2	1388	2	ZC3HAV1	7	138764323	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	5704731	138764323	20374340	185	14339											
ZNF212	7988	broad.mit.edu	37	chr7	148947893	148947893	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taactatgagacactggtctCtctgagtgagtagcagtttt	10	14	10	7	0	2	3	0	3	2	1	3	4	2	3	0	1	2	3	0	1	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:148947893C>G	uc003wfp.2	+	3	632	c.536C>G	c.(535-537)TCT>TGT	p.S179C		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	179	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			ACACTGGTCTCTCTGAGTGAG	0.498													19	44					0	0	0	0	G	148947893	G	G	148947893	3	3	70	1	0	0	0	0	1	0	0	0	17835	913	32	2	546	2	ZNF212	7	148947893	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	10183570	148947893	10190770	186	14340											
SOX7	83595	broad.mit.edu	37	chr8	10683716	10683716	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagattttggacttttcctCaaggctaaaagatttctttt	10	17	8	6	0	2	2	1	0	1	2	3	4	3	3	1	3	0	1	1	3	3	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:10683716C>T	uc011kwz.1	-	5	373	c.340G>A	c.(340-342)GAG>AAG	p.E114K	PINX1_uc003wth.2_Missense_Mutation_p.E114K|PINX1_uc003wti.2_Missense_Mutation_p.E114K|MIR1322_hsa-mir-1322|MI0006653_5'Flank	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GACTTTTCCTCAAGGCTAAAA	0.299													12	6					0	0	0	0	T	10683716	T	T	10683716	3	4	70	1	0	0	0	0	1	0	0	0	15020	835	29	2		2	SOX7	8	10683716	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08		10683716	135680306	187	14341											
SGCZ	137868	broad.mit.edu	37	chr8	14022158	14022158	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaaacagcaccctgccatCttcactggctctcacttcaa	12	9	5	15	0	4	1	3	0	2	1	5	1	4	1	2	1	3	2	2	1	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:14022158C>T	uc003wwq.2	-	5	1138	c.478G>A	c.(478-480)GAT>AAT	p.D160N	SGCZ_uc010lss.2_Missense_Mutation_p.D113N	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	147	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		ACCCTGCCATCTTCACTGGCT	0.423													14	29					0	0	0	0	T	14022158	T	T	14022158	3	4	70	1	0	0	0	0	1	0	0	0	14269	913	32	2	476	2	SGCZ	8	14022158	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3338442	14022158	132341864	188	14342											
RP1	6101	broad.mit.edu	37	chr8	55537868	55537868	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtatctgaaactgaggttCaagagaaaatgattggacag	16	10	11	4	0	2	4	1	3	1	1	2	6	2	5	0	2	1	2	0	2	6	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:55537868C>G	uc003xsd.1	+	4	1574	c.1426C>G	c.(1426-1428)CAA>GAA	p.Q476E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	476					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AACTGAGGTTCAAGAGAAAAT	0.388													18	45					0	0	0	0	G	55537868	G	G	55537868	3	3	70	1	0	0	0	0	1	0	0	0	13597	827	29	2	1436	2	RP1	8	55537868	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	41515710	55537868	90826154	189	14343											
RPS20	6224	broad.mit.edu	37	chr8	56985678	56985678	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaatggtgacttccacctCaactcctggctcaatactga	10	11	7	13	0	2	2	2	2	0	0	4	2	4	2	3	2	3	2	3	2	4	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:56985678C>T	uc003xsn.2	-	4	529	c.331G>A	c.(331-333)GAG>AAG	p.E111K	RPS20_uc003xsm.2_Missense_Mutation_p.E111K	NM_001023	NP_001014	P60866	RS20_HUMAN	ribosomal protein S20 isoform 2	111					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			ACTTCCACCTCAACTCCTGGC	0.388													18	33					0	0	0	0	T	56985678	T	T	56985678	3	4	70	1	0	0	0	0	1	0	0	0	13697	835	29	2	132	2	RPS20	8	56985678	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1447810	56985678	89378344	190	14344											
RRS1	23212	broad.mit.edu	37	chr8	67341837	67341837	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacgacaccaaagaatggctGattgaggtgcccggcaatgc	12	6	13	10	2	0	3	0	2	0	1	0	5	0	3	2	3	2	2	2	3	3	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:67341837G>A	uc003xwa.2	+	1	575	c.471G>A	c.(469-471)CTG>CTA	p.L157L	ADHFE1_uc003xwb.3_5'Flank|ADHFE1_uc003xwd.3_5'Flank|ADHFE1_uc003xwc.3_5'Flank|ADHFE1_uc003xwe.3_5'Flank|ADHFE1_uc003xwf.3_5'Flank|ADHFE1_uc011les.1_5'Flank|ADHFE1_uc011leq.1_5'Flank|ADHFE1_uc011ler.1_5'Flank	NM_015169	NP_055984	Q15050	RRS1_HUMAN	homolog of yeast ribosome biogenesis regulatory	157					mitotic metaphase plate congression|ribosome biogenesis	condensed nuclear chromosome|nucleolus					0		Lung NSC(129;0.197)	Epithelial(68;0.0391)|all cancers(69;0.0898)|BRCA - Breast invasive adenocarcinoma(89;0.111)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			AAGAATGGCTGATTGAGGTGC	0.637													13	19					0	0	0	0	A	67341837	A	A	67341837	2	1	70	1	0	0	0	0	0	0	0	1	13757	1277	45	2		2	RRS1	8	67341837	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	10356159	67341837	79022185	191	14345											
CA3	761	broad.mit.edu	37	chr8	86360296	86360296	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagcctcctctccagtgctGagaacgagcccccagtgcct	7	7	11	16	1	1	1	0	1	1	1	3	4	2	2	6	1	5	1	6	1	1	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:86360296G>A	uc003ydj.2	+	7	780	c.697G>A	c.(697-699)GAG>AAG	p.E233K	CA3_uc011lfv.1_RNA	NM_005181	NP_005172	P07451	CAH3_HUMAN	carbonic anhydrase III	233					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0						CTCCAGTGCTGAGAACGAGCC	0.542													14	17					0	0	0	0	A	86360296	A	A	86360296	3	1	70	1	0	0	0	0	1	0	0	0	2529	1291	45	2	723	2	CA3	8	86360296	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	19018459	86360296	60003726	192	14346											
SDC2	6383	broad.mit.edu	37	chr8	97620608	97620608	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagttcacctctctgactcaGaaaggaaaatggacccagcc	14	7	8	12	0	3	2	2	1	1	1	4	4	3	4	3	2	1	1	3	2	4	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:97620608G>C	uc003yhv.1	+	4	970	c.352G>C	c.(352-354)GAA>CAA	p.E118Q	SDC2_uc011lgu.1_Missense_Mutation_p.E89Q	NM_002998	NP_002989	P34741	SDC2_HUMAN	syndecan 2 precursor	118	Extracellular (Potential).					integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			ovary(2)	2	Breast(36;3.41e-05)				Sargramostim(DB00020)	CTCTGACTCAGAAAGGAAAAT	0.418													7	28					0	0	0	0	C	97620608	C	C	97620608	3	2	70	1	0	0	0	0	1	0	0	0	14017	943	33	2	366	2	SDC2	8	97620608	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	11260312	97620608	48743414	193	14347											
SYBU	55638	broad.mit.edu	37	chr8	110655123	110655123	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccggggaattcggcttcgAgaaatctccttgtcatgatg	10	11	11	9	3	2	2	1	1	1	1	5	4	2	3	2	3	1	1	2	3	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:110655123A>G	uc003ynj.3	-	2	226	c.63T>C	c.(61-63)TCT>TCC	p.S21S	SYBU_uc003yni.3_Silent_p.S18S|SYBU_uc003ynk.3_Intron|SYBU_uc010mco.2_Silent_p.S20S|SYBU_uc003ynl.3_Silent_p.S20S|SYBU_uc010mcp.2_Silent_p.S21S|SYBU_uc010mcq.2_Silent_p.S21S|SYBU_uc003yno.3_Intron|SYBU_uc010mcr.2_Silent_p.S21S|SYBU_uc003ynm.3_Silent_p.S20S|SYBU_uc003ynn.3_Silent_p.S20S|SYBU_uc010mcs.2_Intron|SYBU_uc010mct.2_Silent_p.S21S|SYBU_uc010mcu.2_Silent_p.S20S|SYBU_uc003ynp.3_Intron|SYBU_uc010mcv.2_Silent_p.S21S|uc003ynq.1_5'Flank	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	21	Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						TTCGGCTTCGAGAAATCTCCT	0.478													21	45					0	0	0	0	G	110655123	G	G	110655123	2	3	70	1	0	0	0	0	0	0	0	1	15493	291	11	5		5	SYBU	8	110655123	Silent	SNP	A	TCGA-CN-6011-01A-11D-1683-08	13034515	110655123	35708899	194	14348											
TNFRSF11B	4982	broad.mit.edu	37	chr8	119945204	119945204	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccaaatccaggagggcagctCctatgtttcaagcagaactc	12	8	9	12	0	1	1	1	0	0	1	4	2	3	2	3	2	3	4	3	2	4	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:119945204C>T	uc003yon.3	-	2	689	c.366G>A	c.(364-366)AGG>AGA	p.R122R	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	122	TNFR-Cys 3.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			GAGGGCAGCTCCTATGTTTCA	0.493													11	31					0	0	0	0	T	119945204	T	T	119945204	2	4	70	1	0	0	0	0	0	0	0	1	16351	854	30	2		2	TNFRSF11B	8	119945204	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	9290081	119945204	26418818	195	14349											
TOP1MT	116447	broad.mit.edu	37	chr8	144413487	144413487	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtctccacttcaccccgtCttcgtgcttctccttctccc	2	15	4	20	2	5	0	1	0	4	0	9	0	5	0	5	0	1	1	5	0	0	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:144413487C>T	uc003yxz.2	-	2	164	c.145G>A	c.(145-147)GAC>AAC	p.D49N	TOP1MT_uc011lkd.1_5'UTR|TOP1MT_uc011lke.1_5'UTR|TOP1MT_uc010mfb.2_5'UTR|TOP1MT_uc010mfd.1_5'UTR	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	49					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	TTCACCCCGTCTTCGTGCTTC	0.607													35	17					0	0	0	0	T	144413487	T	T	144413487	3	4	70	1	0	0	0	0	1	0	0	0	16431	913	32	2	1712	2	TOP1MT	8	144413487	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	24468283	144413487	1950535	196	14350											
ZNF251	90987	broad.mit.edu	37	chr8	145948062	145948062	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggggctctggctaaagcctCttccacattcattacacttg	8	12	9	12	0	3	0	1	0	2	0	4	0	4	0	2	3	2	2	2	3	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:145948062C>T	uc003zdv.3	-	5	1239	c.983G>A	c.(982-984)AGA>AAA	p.R328K		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	328	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		GCTAAAGCCTCTTCCACATTC	0.488													17	11					0	0	0	0	T	145948062	T	T	145948062	3	4	70	1	0	0	0	0	1	0	0	0	17863	913	32	2	1036	2	ZNF251	8	145948062	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1534575	145948062	415960	197	14351											
ZNF251	90987	broad.mit.edu	37	chr8	145948232	145948232	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaattgagtccaaaagttttCccacattcatcacatttaaa	15	13	4	9	0	2	1	2	1	0	0	4	2	4	1	2	0	0	1	2	0	5	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:145948232C>T	uc003zdv.3	-	5	1069	c.813G>A	c.(811-813)GGG>GGA	p.G271G		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	271	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		CAAAAGTTTTCCCACATTCAT	0.453													26	21					0	0	0	0	T	145948232	T	T	145948232	2	4	70	1	0	0	0	0	0	0	0	1	17863	842	30	2		2	ZNF251	8	145948232	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	170	145948232	415790	198	14352											
ZNF16	7564	broad.mit.edu	37	chr8	146157372	146157372	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaggctttcccacattcgctGcactggtaagctttctcact	8	13	7	13	1	1	0	1	0	1	0	4	0	2	0	1	2	2	5	1	2	2	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:146157372G>A	uc003zet.2	-	4	988	c.801C>T	c.(799-801)TGC>TGT	p.C267C	ZNF16_uc003zeu.2_Silent_p.C267C	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	267	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		CACATTCGCTGCACTGGTAAG	0.453													4	94					0	0	0	0	A	146157372	A	A	146157372	2	1	70	1	0	0	0	0	0	0	0	1	17805	1311	46	4		4	ZNF16	8	146157372	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	209140	146157372	206650	199	14353											
KIAA2026	158358	broad.mit.edu	37	chr9	6007497	6007497	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctgcagaaagggggcggtGaggccccggtgcttctcctg	5	7	18	11	2	1	2	0	1	1	1	2	2	1	2	3	6	2	3	3	6	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:6007497G>A	uc003zjq.3	-	1	507	c.291C>T	c.(289-291)CTC>CTT	p.L97L		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	97										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AGGGGGCGGTGAGGCCCCGGT	0.716													11	60					0	0	0	0	A	6007497	A	A	6007497	2	1	70	1	0	0	0	0	0	0	0	1	8309	1277	45	2		2	KIAA2026	9	6007497	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08		6007497	135205934	200	14354											
BNC2	54796	broad.mit.edu	37	chr9	16436013	16436013	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtttgggctccgaagactCagactcgttctcatagtccc	8	11	9	13	2	2	2	2	0	1	2	6	3	4	2	2	1	0	3	2	1	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:16436013C>G	uc003zml.2	-	6	2319	c.2179G>C	c.(2179-2181)GAG>CAG	p.E727Q	BNC2_uc011lmw.1_Missense_Mutation_p.E632Q|BNC2_uc003zmm.2_Missense_Mutation_p.E685Q|BNC2_uc003zmq.1_Missense_Mutation_p.E741Q|BNC2_uc003zmr.1_Missense_Mutation_p.E764Q|BNC2_uc003zmp.1_Missense_Mutation_p.E755Q|BNC2_uc010mij.1_Missense_Mutation_p.E649Q|BNC2_uc011lmv.1_Missense_Mutation_p.E553Q|BNC2_uc003zmo.1_Missense_Mutation_p.E649Q|BNC2_uc003zmj.2_Missense_Mutation_p.E492Q|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.E492Q|BNC2_uc003zmn.1_Missense_Mutation_p.E492Q	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	727					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		TCCGAAGACTCAGACTCGTTC	0.512													155	44					0	0	0	0	G	16436013	G	G	16436013	3	3	70	1	0	0	0	0	1	0	0	0	1478	835	29	2	1128	2	BNC2	9	16436013	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	10428516	16436013	124777418	201	14355											
HAUS6	54801	broad.mit.edu	37	chr9	19058235	19058235	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttcccttttcttggaaaGagatttcttcagagcctcgt	7	17	7	10	1	4	2	1	0	3	2	6	4	5	3	2	1	1	0	2	1	1	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:19058235G>C	uc003znk.2	-	16	2783	c.2530C>G	c.(2530-2532)CTT>GTT	p.L844V	HAUS6_uc011lmz.1_Missense_Mutation_p.L564V|HAUS6_uc003znl.1_Missense_Mutation_p.L708V	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	844					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2						TTCTTGGAAAGAGATTTCTTC	0.433													29	353					0	0	0	0	C	19058235	C	C	19058235	3	2	70	1	0	0	0	0	1	0	0	0	7009	942	33	2	345	2	HAUS6	9	19058235	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2622222	19058235	122155196	202	14356											
PIGO	84720	broad.mit.edu	37	chr9	35092757	35092757	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgagtaggtatgaagaaatCgggacacctggcagagaaaa	16	6	13	6	1	0	4	0	2	0	2	1	6	0	5	1	3	0	3	1	3	6	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:35092757C>T	uc003zwd.2	-	7	1523	c.1127G>A	c.(1126-1128)CGA>CAA	p.R376Q	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Missense_Mutation_p.R376Q|PIGO_uc003zwf.2_Missense_Mutation_p.R376Q|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	376					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ATGAAGAAATCGGGACACCTG	0.512													25	17					0	0	0	0	T	35092757	T	T	35092757	3	4	70	1	0	0	0	0	1	0	0	0	11949	884	31	1	2162	1	PIGO	9	35092757	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	16034522	35092757	106120674	203	14357											
FAM75A6	389730	broad.mit.edu	37	chr9	43627116	43627116	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagcttgcactttattctgcGatgcagggcaagctactcca	9	11	10	11	1	1	0	0	0	1	0	2	2	2	0	1	1	6	5	1	1	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:43627116G>A	uc011lrb.1	-	4	1600	c.1571C>T	c.(1570-1572)TCG>TTG	p.S524L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	524						integral to membrane					0						TTTATTCTGCGATGCAGGGCA	0.507													70	336					0	0	0	0	A	43627116	A	A	43627116	3	1	70	1	0	0	0	0	1	0	0	0	5654	1059	37	1	2464	1	FAM75A6	9	43627116	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	8534359	43627116	97586315	204	14358											
TMEM2	23670	broad.mit.edu	37	chr9	74347373	74347373	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caatattccgggtaagaattCcaacctcagctctcatgtct	11	12	6	12	1	3	1	2	0	2	1	6	1	5	1	3	1	2	2	3	1	5	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:74347373C>G	uc011lsa.1	-	7	1997	c.1457G>C	c.(1456-1458)GGA>GCA	p.G486A	TMEM2_uc010mos.2_Missense_Mutation_p.G423A|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	486						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		GGTAAGAATTCCAACCTCAGC	0.428													21	54					0	0	0	0	G	74347373	G	G	74347373	3	3	70	1	0	0	0	0	1	0	0	0	16187	855	30	2	2766	2	TMEM2	9	74347373	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	30720257	74347373	66866058	205	14359											
SECISBP2	79048	broad.mit.edu	37	chr9	91963111	91963111	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggtgatgaccagtttcccGagcaggcagagctgtcaggt	8	9	15	9	1	1	3	1	2	0	1	2	4	2	3	2	3	2	4	2	3	0	1	rs147681365		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:91963111G>A	uc004aqj.1	+	12	1800	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K	SECISBP2_uc011ltk.1_Missense_Mutation_p.E573K|SECISBP2_uc004aqk.1_Missense_Mutation_p.E501K|SECISBP2_uc010mqo.1_Missense_Mutation_p.E279K|SECISBP2_uc011ltl.1_Missense_Mutation_p.E506K	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	574					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						CCAGTTTCCCGAGCAGGCAGA	0.463													19	71					0	0	0	0	A	91963111	A	A	91963111	3	1	70	1	0	0	0	0	1	0	0	0	14071	1059	37	1	1766	1	SECISBP2	9	91963111	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	17615738	91963111	49250320	206	14360											
SEMA4D	10507	broad.mit.edu	37	chr9	92003801	92003801	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttacagctgtggggtgaaGagtgcatagaacacaggcac	13	7	13	8	0	0	3	0	1	0	2	0	3	0	3	0	3	4	3	0	3	4	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:92003801G>A	uc004aqo.1	-	12	1508	c.936C>T	c.(934-936)CTC>CTT	p.L312L	SEMA4D_uc011ltm.1_Silent_p.L312L|SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aqp.1_Silent_p.L310L	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	312	Sema.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						GTGGGGTGAAGAGTGCATAGA	0.617													26	95					0	0	0	0	A	92003801	A	A	92003801	2	1	70	1	0	0	0	0	0	0	0	1	14099	929	33	2		2	SEMA4D	9	92003801	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	40690	92003801	49209630	207	14361											
SEMA4D	10507	broad.mit.edu	37	chr9	92017921	92017921	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggctcatgaaactgcacCaggtgcacctctgtgggatg	8	10	12	11	0	3	1	1	1	2	0	3	2	3	2	2	3	3	3	2	3	1	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:92017921C>T	uc004aqo.1	-	6	689	c.117G>A	c.(115-117)CTG>CTA	p.L39L	SEMA4D_uc011ltm.1_Silent_p.L39L|SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aqp.1_Silent_p.L37L	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	39	Sema.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						GAAACTGCACCAGGTGCACCT	0.547													10	48					0	0	0	0	T	92017921	T	T	92017921	2	4	70	1	0	0	0	0	0	0	0	1	14099	581	21	4		4	SEMA4D	9	92017921	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	14120	92017921	49195510	208	14362											
SYK	6850	broad.mit.edu	37	chr9	93650072	93650072	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgtcaagtggtacgctccGgaatgcatcaactactacaa	12	9	8	12	2	2	0	2	0	0	0	3	1	3	1	2	2	5	3	2	2	7	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:93650072G>A	uc004aqz.2	+	12	1828	c.1623G>A	c.(1621-1623)CCG>CCA	p.P541P	SYK_uc004ara.2_Silent_p.P518P|SYK_uc004arb.2_Silent_p.P518P|SYK_uc004arc.2_Silent_p.P541P|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	541	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						GGTACGCTCCGGAATGCATCA	0.438			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								7	164					0	0	0	0	A	93650072	A	A	93650072	2	1	70	1	0	0	0	0	0	0	0	1	15504	1103	39	1		1	SYK	9	93650072	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1632151	93650072	47563359	209	14363											
NOL8	55035	broad.mit.edu	37	chr9	95062221	95062221	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcagtaacatcttcctcttCtgaactgctgtcttgtaaac	9	16	5	11	0	5	1	1	1	4	0	6	1	6	1	1	0	4	3	1	0	4	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:95062221C>G	uc004arv.2	-	14	3590	c.3253G>C	c.(3253-3255)GAA>CAA	p.E1085Q	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Missense_Mutation_p.E317Q|NOL8_uc011ltw.1_Missense_Mutation_p.E1017Q	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	1085					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						TCTTCCTCTTCTGAACTGCTG	0.388													57	185					0	0	0	0	G	95062221	G	G	95062221	3	3	70	1	0	0	0	0	1	0	0	0	10581	922	32	2	266	2	NOL8	9	95062221	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1412149	95062221	46151210	210	14364											
MURC	347273	broad.mit.edu	37	chr9	103340680	103340680	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catagcaatacagggcatatCattaacaaattgtttgagaa	17	11	7	6	0	1	1	1	1	0	1	1	2	1	1	0	1	3	3	0	1	7	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:103340680C>T	uc004bba.2	+	1	345	c.255C>T	c.(253-255)ATC>ATT	p.I85I		NM_001018116	NP_001018126	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	85					cell differentiation|muscle organ development|transcription, DNA-dependent					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0461)				CAGGGCATATCATTAACAAAT	0.388													25	67					0	0	0	0	T	103340680	T	T	103340680	2	4	70	1	0	0	0	0	0	0	0	1	10040	816	29	2		2	MURC	9	103340680	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	8278459	103340680	37872751	211	14365											
ACTL7B	10880	broad.mit.edu	37	chr9	111617356	111617356	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaatagtgatgagtttgccGtccgggagctcgtagtccac	8	10	12	11	3	0	2	0	2	0	0	3	3	2	3	4	1	2	3	4	1	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:111617356G>A	uc004bdi.2	-	1	920	c.855C>T	c.(853-855)GAC>GAT	p.D285D		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	285						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TGAGTTTGCCGTCCGGGAGCT	0.642													78	30					0	0	0	0	A	111617356	A	A	111617356	2	1	70	1	0	0	0	0	0	0	0	1	201	1136	40	1		1	ACTL7B	9	111617356	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	8276676	111617356	29596075	212	14366											
OR2K2	26248	broad.mit.edu	37	chr9	114090514	114090514	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtaacaaatatccatgaaaGagagatttccaaggaataag	19	9	8	5	0	0	3	0	1	0	2	2	5	2	4	2	1	1	1	2	1	7	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:114090514G>C	uc011lwp.1	-	1	200	c.200C>G	c.(199-201)TCT>TGT	p.S67C		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	96	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCCATGAAAGAGAGATTTCC	0.418													25	44					0	0	0	0	C	114090514	C	C	114090514	3	2	70	1	0	0	0	0	1	0	0	0	11059	942	33	2	753	2	OR2K2	9	114090514	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2473158	114090514	27122917	213	14367											
ALAD	210	broad.mit.edu	37	chr9	116152945	116152945	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcccggaatgctccgttttCactcaggagcccttcaggac	8	9	10	14	2	3	0	3	0	0	0	4	3	4	3	3	3	3	2	3	3	1	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:116152945C>T	uc011lxf.1	-	6	611	c.409G>A	c.(409-411)GAA>AAA	p.E137K	ALAD_uc011lxe.1_Missense_Mutation_p.E120K|ALAD_uc004bhl.3_Missense_Mutation_p.E166K	NM_000031	NP_000022	P13716	HEM2_HUMAN	delta-aminolevulinic acid dehydratase	137					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding				0					Aminolevulinic acid(DB00855)	GCTCCGTTTTCACTCAGGAGC	0.622													9	19					0	0	0	0	T	116152945	T	T	116152945	3	4	70	1	0	0	0	0	1	0	0	0	483	835	29	2	611	2	ALAD	9	116152945	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2062431	116152945	25060486	214	14368											
ZNF618	114991	broad.mit.edu	37	chr9	116794974	116794974	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaaagcacaaaaccacttTgaagagacgaacagcagttc	17	5	9	10	1	0	2	0	1	0	1	1	4	0	2	1	1	4	4	1	1	5	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:116794974T>G	uc004bid.2	+	12	1233	c.1134T>G	c.(1132-1134)TTT>TTG	p.F378L	ZNF618_uc004bic.2_Missense_Mutation_p.F285L|ZNF618_uc011lxi.1_Missense_Mutation_p.F345L|ZNF618_uc011lxj.1_Missense_Mutation_p.F346L|ZNF618_uc010mvb.2_5'UTR	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	378					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAACCACTTTGAAGAGACGA	0.562													39	71					0	0	0	0	G	116794974	G	G	116794974	3	3	70	1	0	0	0	0	1	0	0	0	18109	1809	63	5	897	5	ZNF618	9	116794974	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	642029	116794974	24418457	215	14369											
PBX3	5090	broad.mit.edu	37	chr9	128678148	128678148	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattgaacactcagattacaGagccaaattgacccagatca	16	9	6	10	0	2	5	2	2	0	3	2	5	2	5	2	0	3	0	2	0	4	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:128678148G>A	uc004bqb.2	+	3	574	c.458G>A	c.(457-459)AGA>AAA	p.R153K	PBX3_uc004bqc.2_Intron|PBX3_uc004bqd.2_Intron|PBX3_uc011lzw.1_Missense_Mutation_p.R78K|PBX3_uc011lzx.1_Missense_Mutation_p.R64K|PBX3_uc004bqe.2_Missense_Mutation_p.R40K	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	153					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						TCAGATTACAGAGCCAAATTG	0.507													31	99					0	0	0	0	A	128678148	A	A	128678148	3	1	70	1	0	0	0	0	1	0	0	0	11548	942	33	2	468	2	PBX3	9	128678148	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	11883174	128678148	12535283	216	14370											
GARNL3	84253	broad.mit.edu	37	chr9	130119513	130119513	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaggagatctgtctgtctGactctcccatggtgatgacc	8	11	10	12	0	4	4	0	3	4	1	5	5	4	4	2	2	0	0	2	2	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:130119513G>C	uc011mae.1	+	21	2352	c.1951G>C	c.(1951-1953)GAC>CAC	p.D651H	GARNL3_uc011mad.1_Missense_Mutation_p.D629H|GARNL3_uc010mxi.2_5'UTR	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	651	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CTGTCTGTCTGACTCTCCCAT	0.522													43	45					0	0	0	0	C	130119513	C	C	130119513	3	2	70	1	0	0	0	0	1	0	0	0	6276	1290	45	2	2033	2	GARNL3	9	130119513	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1441365	130119513	11093918	217	14371											
GARNL3	84253	broad.mit.edu	37	chr9	130119609	130119609	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaatttgatgtggtgaatGagagcacaggagaagccttc	13	9	12	7	0	0	4	0	3	0	2	1	6	0	4	2	2	2	1	2	2	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:130119609G>C	uc011mae.1	+	21	2448	c.2047G>C	c.(2047-2049)GAG>CAG	p.E683Q	GARNL3_uc011mad.1_Missense_Mutation_p.E661Q|GARNL3_uc010mxi.2_5'UTR	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	683	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TGTGGTGAATGAGAGCACAGG	0.507													23	27					0	0	0	0	C	130119609	C	C	130119609	3	2	70	1	0	0	0	0	1	0	0	0	6276	1291	45	2	2129	2	GARNL3	9	130119609	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	96	130119609	11093822	218	14372											
NUP214	8021	broad.mit.edu	37	chr9	134073419	134073419	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacagtgaggtctcagcatCagcagcctcacttctagagg	10	9	11	11	0	4	3	3	2	2	1	5	3	4	3	1	2	3	2	1	2	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:134073419C>T	uc004cag.2	+	29	4649	c.4538C>T	c.(4537-4539)TCA>TTA	p.S1513L	NUP214_uc004cah.2_Missense_Mutation_p.S1503L|NUP214_uc004cai.2_Missense_Mutation_p.S943L|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.S339L|NUP214_uc011mcf.1_Missense_Mutation_p.S290L|NUP214_uc010mzh.1_Missense_Mutation_p.S27L|NUP214_uc010mzi.1_Missense_Mutation_p.S27L	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1513	Pro/Ser/Thr-rich.|11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GTCTCAGCATCAGCAGCCTCA	0.552			T	DEK|SET|ABL1	AML|T-ALL								15	102					0	0	0	0	T	134073419	T	T	134073419	3	4	70	1	0	0	0	0	1	0	0	0	10816	838	29	2	4652	2	NUP214	9	134073419	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3953810	134073419	7140012	219	14373											
NOTCH1	4851	broad.mit.edu	37	chr9	139401080	139401080	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagccattgatgacggactCgcagcggcgccctaggggta	8	6	15	12	4	0	2	0	2	0	0	1	3	0	3	2	4	2	3	2	4	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:139401080C>T	uc004chz.2	-	24	3913	c.3913G>A	c.(3913-3915)GAG>AAG	p.E1305K	NOTCH1_uc004cia.1_Missense_Mutation_p.E535K	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1305	Extracellular (Potential).|EGF-like 33.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ATGACGGACTCGCAGCGGCGC	0.692			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			9	11					0	0	0	0	T	139401080	T	T	139401080	3	4	70	1	0	0	0	0	1	0	0	0	10601	893	31	1	3798	1	NOTCH1	9	139401080	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	5327661	139401080	1812351	220	14374											
AKR1C4	1109	broad.mit.edu	37	chr10	5254582	5254582	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcttgatcatctaaaggtaGaatgtcatccttacctcaac	12	13	5	11	0	5	2	3	1	2	1	6	2	6	2	2	1	2	1	2	1	6	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:5254582G>C	uc001ihw.2	+	6	607	c.574G>C	c.(574-576)GAA>CAA	p.E192Q		NM_001818	NP_001809	P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	192					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			ovary(1)	1					NADH(DB00157)	TCTAAAGGTAGAATGTCATCC	0.348													11	30					0	0	0	0	C	5254582	C	C	5254582	3	2	70	1	0	0	0	0	1	0	0	0	472	943	33	2	596	2	AKR1C4	10	5254582	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08		5254582	130280165	221	14375											
PCDH15	65217	broad.mit.edu	37	chr10	55912906	55912906	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctgcttggaccgtgagtgCgtaagtccgcccgactatca	7	9	12	13	5	1	1	1	1	0	0	2	3	2	2	3	1	2	3	3	1	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:55912906C>A	uc001jju.1	-	14	2133	c.1738G>T	c.(1738-1740)GCA>TCA	p.A580S	PCDH15_uc010qhq.1_Missense_Mutation_p.A585S|PCDH15_uc010qhr.1_Missense_Mutation_p.A580S|PCDH15_uc010qhs.1_Missense_Mutation_p.A592S|PCDH15_uc010qht.1_Missense_Mutation_p.A587S|PCDH15_uc010qhu.1_Missense_Mutation_p.A580S|PCDH15_uc001jjv.1_Missense_Mutation_p.A558S|PCDH15_uc010qhv.1_Missense_Mutation_p.A580S|PCDH15_uc010qhw.1_Missense_Mutation_p.A543S|PCDH15_uc010qhx.1_Missense_Mutation_p.A580S|PCDH15_uc010qhy.1_Missense_Mutation_p.A585S|PCDH15_uc010qhz.1_Missense_Mutation_p.A580S|PCDH15_uc010qia.1_Missense_Mutation_p.A558S|PCDH15_uc010qib.1_Missense_Mutation_p.A558S|PCDH15_uc001jjw.2_Missense_Mutation_p.A580S	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	580	Cadherin 5.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACCGTGAGTGCGTAAGTCCGC	0.488										HNSCC(58;0.16)			12	31					0.000978159	0.00100246	1	0	A	55912906	A	A	55912906	3	1	70	1	0	0	0	0	1	0	0	0	11565	768	27	3	5828	3	PCDH15	10	55912906	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	50658324	55912906	79621841	222	14376											
BICC1	80114	broad.mit.edu	37	chr10	60272997	60272997	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actccccagtgcccggctccGaggacgacttggtcgccggg	5	6	14	16	5	0	0	0	0	0	0	3	3	2	1	5	4	1	1	5	4	0	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:60272997G>A	uc001jki.1	+	1	94	c.94G>A	c.(94-96)GAG>AAG	p.E32K		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	32					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						GCCCGGCTCCGAGGACGACTT	0.697													13	18					0	0	0	0	A	60272997	A	A	60272997	3	1	70	1	0	0	0	0	1	0	0	0	1430	1059	37	1	96	1	BICC1	10	60272997	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	4360091	60272997	75261750	223	14377											
PLAU	5328	broad.mit.edu	37	chr10	75672797	75672797	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccactgtccttcagcaaacGtaccatgcccacagatctga	11	8	7	15	1	2	2	1	1	1	1	3	2	3	2	4	0	4	2	4	0	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:75672797G>A	uc001jwa.2	+	5	455	c.309G>A	c.(307-309)ACG>ACA	p.T103T	C10orf55_uc001jvz.1_Intron|PLAU_uc010qkw.1_Silent_p.T86T|PLAU_uc010qkx.1_Silent_p.T17T|PLAU_uc001jwb.2_RNA|PLAU_uc001jwc.2_Silent_p.T103T|PLAU_uc009xrq.1_Silent_p.T67T	NM_002658	NP_002649	P00749	UROK_HUMAN	plasminogen activator, urokinase isoform 1	103	Kringle.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(2)|kidney(1)	3	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	TTCAGCAAACGTACCATGCCC	0.572													10	47					0	0	0	0	A	75672797	A	A	75672797	2	1	70	1	0	0	0	0	0	0	0	1	12077	1132	40	1		1	PLAU	10	75672797	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	15399800	75672797	59861950	224	14378											
SEMA4G	57715	broad.mit.edu	37	chr10	102743390	102743390	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcacagctggcacctgatgtGagactgctctatgtgctagc	8	10	12	11	0	1	2	0	2	1	1	1	3	1	2	1	1	4	5	1	1	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:102743390G>C	uc001krw.1	+	14	2418	c.2034G>C	c.(2032-2034)GTG>GTC	p.V678V	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krx.2_Intron|MRPL43_uc001kry.1_Intron|MRPL43_uc010qpu.1_Intron|MRPL43_uc001krz.1_Intron|MRPL43_uc001ksa.1_Intron|MRPL43_uc001ksb.1_Intron	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	673	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		CACCTGATGTGAGACTGCTCT	0.637													3	21					0	0	0	0	C	102743390	C	C	102743390	2	2	70	1	0	0	0	0	0	0	0	1	14101	1277	45	2		2	SEMA4G	10	102743390	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	27070593	102743390	32791357	225	14379											
PDCD11	22984	broad.mit.edu	37	chr10	105174042	105174042	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctaggtctattattgaagcTcagtaccttagatatcatga	12	14	7	8	0	3	3	2	2	1	1	3	3	3	3	2	1	2	2	2	1	7	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:105174042T>C	uc001kwy.1	+	11	1413	c.1326T>C	c.(1324-1326)GCT>GCC	p.A442A		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	442					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTATTGAAGCTCAGTACCTTA	0.433													16	28					0	0	0	0	C	105174042	C	C	105174042	2	2	70	1	0	0	0	0	0	0	0	1	11671	1538	54	5		5	PDCD11	10	105174042	Silent	SNP	T	TCGA-CN-6011-01A-11D-1683-08	2430652	105174042	30360705	226	14380											
PNLIPRP3	119548	broad.mit.edu	37	chr10	118202613	118202613	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tatccaagcctcatattttgGaacagacaagatcacccgta	14	10	6	11	1	2	2	2	0	0	2	3	3	3	3	3	1	2	1	3	1	6	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:118202613G>T	uc001lcl.3	+	3	352	c.251G>T	c.(250-252)GGA>GTA	p.G84V		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	84					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		TCATATTTTGGAACAGACAAG	0.348													9	31					1.12685e-05	1.17183e-05	1	0	T	118202613	T	T	118202613	3	4	70	1	0	0	0	0	1	0	0	0	12207	1174	41	2	261	2	PNLIPRP3	10	118202613	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	13028571	118202613	17332134	227	14381											
LHPP	64077	broad.mit.edu	37	chr10	126172787	126172787	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagctggtggggcagcttCagaggctgggatttgacatc	8	9	16	8	0	1	3	1	1	0	2	2	4	1	4	0	5	2	4	0	5	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:126172787C>T	uc001lhs.1	+	2	225	c.205C>T	c.(205-207)CAG>TAG	p.Q69*	LHPP_uc001lht.1_Nonsense_Mutation_p.Q69*|LHPP_uc009yai.1_Nonsense_Mutation_p.Q69*	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	69					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)		GGGGCAGCTTCAGAGGCTGGG	0.627													13	51					0	0	0	0	T	126172787	T	T	126172787	4	4	70	1	0	0	0	0	0	1	0	0	8810	827	29	2	211	2	LHPP	10	126172787	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	7970174	126172787	9361960	228	14382											
KRTAP5-3	387266	broad.mit.edu	37	chr11	1628959	1628959	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gactgggaggagcagggcttGcagcagctggactggcagca	9	5	18	9	0	0	0	0	0	0	0	0	4	0	3	0	5	5	7	0	5	0	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1628959G>A	uc001ltw.1	-	1	735	c.657C>T	c.(655-657)TGC>TGT	p.C219C		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	219	11 X 4 AA repeats of C-C-X-P.|10.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		AGCAGGGCTTgcagcagctgg	0.294													6	169					0	0	0	0	A	1628959	A	A	1628959	2	1	70	1	0	0	0	0	0	0	0	1	8602	1311	46	4		4	KRTAP5-3	11	1628959	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08		1628959	133377557	229	14383											
KRTAP5-4	387267	broad.mit.edu	37	chr11	1642736	1642736	+	Silent	SNP	G	A	A																															caggatgacccacaacctgaGgaggagcagcagggcttaca																										TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1642736G>A	uc009ycy.1	-	4	813	c.726C>T	c.(724-726)TCC>TCT	p.S242S		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	256	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CACAACCTGAGGAGGAGCAGC	0.597													6	114					0	0	0	0	A	1642736	A	A	1642736	2	1	70	1	0	0	0	0	0	0	0	1	8603	987	35	4		4	KRTAP5-4	11	1642736	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	13777	1642736	133363780	230	14384	29	2									
KRTAP5-4	387267	broad.mit.edu	37	chr11	1642740	1642740	+	Missense_Mutation	SNP	G	C	C																															atgacccacaacctgaggagGagcagcagggcttacagcag																										TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1642740G>C	uc009ycy.1	-	4	809	c.722C>G	c.(721-723)TCC>TGC	p.S241C		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	255	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ACCTGAGGAGGAGCAGCAGGG	0.597													6	115					0	0	0	0	C	1642740	C	C	1642740	3	2	70	1	0	0	0	0	1	0	0	0	8603	1174	41	2	106	2	KRTAP5-4	11	1642740	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	4	1642740	133363776	231	14385	29	2									
OR52K1	390036	broad.mit.edu	37	chr11	4510323	4510323	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaacccatgtacctctttCtggccatgttggcaaccatt	9	13	7	12	0	2	1	0	1	2	0	2	1	2	1	4	2	3	3	4	2	3	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:4510323C>G	uc001lza.1	+	1	193	c.193C>G	c.(193-195)CTG>GTG	p.L65V		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		GTACCTCTTTCTGGCCATGTT	0.488													34	22					0	0	0	0	G	4510323	G	G	4510323	3	3	70	1	0	0	0	0	1	0	0	0	11177	912	32	2	195	2	OR52K1	11	4510323	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2867583	4510323	130496193	232	14386											
OR51A7	119687	broad.mit.edu	37	chr11	4929349	4929349	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgtgctgtgctcaccttCtatgtgcccatcatcaccct	6	14	6	15	0	5	0	3	0	2	0	5	0	5	0	3	0	3	2	3	0	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:4929349C>A	uc010qyq.1	+	1	750	c.750C>A	c.(748-750)TTC>TTA	p.F250L		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTCACCTTCTATGTGCCCA	0.483													40	56					4.17593e-13	4.48392e-13	1	0	A	4929349	A	A	4929349	3	1	70	1	0	0	0	0	1	0	0	0	11142	912	32	2	752	2	OR51A7	11	4929349	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	419026	4929349	130077167	233	14387											
KCNA4	3739	broad.mit.edu	37	chr11	30034073	30034073	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccagaacccccgctaccttcGacagcagctgtggccgctgc	7	6	10	18	3	0	1	0	0	0	1	1	2	0	1	5	1	5	4	5	1	2	2	rs60942363		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:30034073G>C	uc001msk.2	-	2	1305	c.153C>G	c.(151-153)GTC>GTG	p.V51V		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	51						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CGCTACCTTCGACAGCAGCTG	0.677													14	16					0	0	0	0	C	30034073	C	C	30034073	2	2	70	1	0	0	0	0	0	0	0	1	8044	1045	37	3		3	KCNA4	11	30034073	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	25104724	30034073	104972443	234	14388											
TTC17	55761	broad.mit.edu	37	chr11	43411297	43411297	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagaagacccagactgcatCaaagccaaggtgcccttagg	15	5	10	11	0	1	3	1	0	0	3	1	3	1	3	3	2	3	1	3	2	5	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:43411297C>G	uc001mxi.2	+	3	359	c.345C>G	c.(343-345)ATC>ATG	p.I115M	TTC17_uc001mxh.2_Missense_Mutation_p.I115M|TTC17_uc010rfj.1_Missense_Mutation_p.I58M	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	115							binding			ovary(5)	5						CAGACTGCATCAAAGCCAAGG	0.398													27	134					0	0	0	0	G	43411297	G	G	43411297	3	3	70	1	0	0	0	0	1	0	0	0	16752	816	29	2	355	2	TTC17	11	43411297	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	13377224	43411297	91595219	235	14389											
OR4A16	81327	broad.mit.edu	37	chr11	55111514	55111514	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attcaattatcacactcatgTtgaatcctttaatatactcg	13	16	3	9	1	3	1	3	1	0	0	5	1	4	1	1	0	1	1	1	0	6	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:55111514T>A	uc010rie.1	+	1	838	c.838T>A	c.(838-840)TTG>ATG	p.L280M		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						CACACTCATGTTGAATCCTTT	0.318													13	54					0	0	0	0	A	55111514	A	A	55111514	3	1	70	1	0	0	0	0	1	0	0	0	11095	1722	60	5	840	5	OR4A16	11	55111514	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	11700217	55111514	79895002	236	14390											
SPRYD5	84767	broad.mit.edu	37	chr11	55658863	55658863	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagacagaatgacaagataGatggagaggagggactcttt	16	7	14	4	0	1	6	0	1	1	5	1	10	1	8	0	3	0	0	0	3	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:55658863G>C	uc010rip.1	+	7	1206	c.1114G>C	c.(1114-1116)GAT>CAT	p.D372H	SPRYD5_uc010riq.1_Missense_Mutation_p.D229H	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	372	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TGACAAGATAGATGGAGAGGA	0.443													17	63					0	0	0	0	C	55658863	C	C	55658863	3	2	70	1	0	0	0	0	1	0	0	0	15177	942	33	2	1136	2	SPRYD5	11	55658863	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	547349	55658863	79347653	237	14391											
OR8H3	390152	broad.mit.edu	37	chr11	55890553	55890553	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattccacttcaggaaagcaGaaagctttctctacttgcgt	12	12	7	10	1	2	1	1	0	1	1	4	2	3	2	1	1	4	2	1	1	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:55890553G>C	uc001nii.1	+	1	705	c.705G>C	c.(703-705)CAG>CAC	p.Q235H		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					CAGGAAAGCAGAAAGCTTTCT	0.413													19	117					0	0	0	0	C	55890553	C	C	55890553	3	2	70	1	0	0	0	0	1	0	0	0	11293	933	33	2	707	2	OR8H3	11	55890553	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	231690	55890553	79115963	238	14392											
SSRP1	6749	broad.mit.edu	37	chr11	57097867	57097867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcatcatgctggtcctcatCagagtcagcatattcatcgt	9	12	9	11	1	5	1	5	0	0	1	7	1	6	1	1	2	2	3	1	2	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:57097867C>T	uc001njt.2	-	11	1600	c.1333G>A	c.(1333-1335)GAT>AAT	p.D445N		NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	445	Asp/Glu-rich (acidic).				DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						TGGTCCTCATCAGAGTCAGCA	0.537													4	31					0	0	0	0	T	57097867	T	T	57097867	3	4	70	1	0	0	0	0	1	0	0	0	15260	826	29	2	824	2	SSRP1	11	57097867	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1207314	57097867	77908649	239	14393											
ZDHHC5	25921	broad.mit.edu	37	chr11	57466638	57466638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cattcagtcaacaccaggctCgggccatgcccctcgtacta	9	8	8	16	2	2	0	2	0	0	0	4	0	2	0	4	2	3	2	4	2	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:57466638C>T	uc001nkx.1	+	11	2986	c.1730C>T	c.(1729-1731)TCG>TTG	p.S577L	ZDHHC5_uc001nky.1_Missense_Mutation_p.S524L|ZDHHC5_uc001nkz.1_Missense_Mutation_p.S391L	NM_015457	NP_056272	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC domain containing 5	577						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)	1						ACACCAGGCTCGGGCCATGCC	0.597													34	144					0	0	0	0	T	57466638	T	T	57466638	3	4	70	1	0	0	0	0	1	0	0	0	17685	893	31	1	1768	1	ZDHHC5	11	57466638	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	368771	57466638	77539878	240	14394											
OR5B3	441608	broad.mit.edu	37	chr11	58170596	58170596	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaagatatacatttgagcaGcacatgcattgtaagagatg	16	10	9	6	0	0	3	0	1	0	2	0	4	0	3	0	0	4	4	0	0	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:58170596G>C	uc010rkf.1	-	1	287	c.287C>G	c.(286-288)GCT>GGT	p.A96G		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CATTTGAGCAGCACATGCATT	0.448													24	87					0	0	0	0	C	58170596	C	C	58170596	3	2	70	1	0	0	0	0	1	0	0	0	11206	971	34	4	659	4	OR5B3	11	58170596	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	703958	58170596	76835920	241	14395											
OR5A2	219981	broad.mit.edu	37	chr11	59190242	59190242	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacaggttactgaggaagAagtacatgggcatgtgcagg	13	7	16	5	0	0	2	0	1	0	1	0	4	0	4	0	5	3	4	0	5	4	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:59190242A>G	uc010rkt.1	-	1	185	c.185T>C	c.(184-186)TTC>TCC	p.F62S		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTGAGGAAGAAGTACATGGG	0.488													29	52					0	0	0	0	G	59190242	G	G	59190242	3	3	70	1	0	0	0	0	1	0	0	0	11194	246	9	5	791	5	OR5A2	11	59190242	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08	1019646	59190242	75816274	242	14396											
OR4D9	390199	broad.mit.edu	37	chr11	59283060	59283060	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggtcatcttgatgatgctGaggtctcacactggggaagg	9	10	14	8	1	3	3	2	3	2	0	4	4	3	4	0	5	1	1	0	5	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:59283060G>C	uc010rkv.1	+	1	675	c.675G>C	c.(673-675)CTG>CTC	p.L225L		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGATGATGCTGAGGTCTCACA	0.488													32	167					0	0	0	0	C	59283060	C	C	59283060	2	2	70	1	0	0	0	0	0	0	0	1	11113	1277	45	2		2	OR4D9	11	59283060	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	92818	59283060	75723456	243	14397											
MS4A3	932	broad.mit.edu	37	chr11	59829989	59829989	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctggctttgggtgtctttCtgggttccttgcaataccca	4	17	10	10	0	3	0	0	0	3	0	4	0	4	0	2	3	2	3	2	3	2	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:59829989C>T	uc001nom.2	+	3	333	c.205C>T	c.(205-207)CTG>TTG	p.L69L	MS4A3_uc001non.2_Intron|MS4A3_uc001noo.2_Intron	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	69	Helical; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				GGGTGTCTTTCTGGGTTCCTT	0.453													25	102					0	0	0	0	T	59829989	T	T	59829989	2	4	70	1	0	0	0	0	0	0	0	1	9914	912	32	2		2	MS4A3	11	59829989	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	546929	59829989	75176527	244	14398											
MS4A14	84689	broad.mit.edu	37	chr11	60183118	60183118	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaaccaggtaataaaggtaGagaatttgtgccagatgaac	16	8	10	7	0	0	3	0	1	0	2	0	4	0	3	3	2	3	2	3	2	7	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:60183118G>C	uc001npj.2	+	5	1242	c.677G>C	c.(676-678)AGA>ACA	p.R226T	MS4A14_uc001npi.2_Missense_Mutation_p.R114T|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.R209T|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	226						integral to membrane	receptor activity			breast(1)	1						AATAAAGGTAGAGAATTTGTG	0.403													22	87					0	0	0	0	C	60183118	C	C	60183118	3	2	70	1	0	0	0	0	1	0	0	0	9911	942	33	2	695	2	MS4A14	11	60183118	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	353129	60183118	74823398	245	14399											
MS4A14	84689	broad.mit.edu	37	chr11	60183186	60183186	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattttcagaggaagaaattGaacctttgcctcccacacta	14	11	6	10	0	1	3	1	1	0	2	2	4	2	4	3	1	2	0	3	1	5	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:60183186G>A	uc001npj.2	+	5	1310	c.745G>A	c.(745-747)GAA>AAA	p.E249K	MS4A14_uc001npi.2_Missense_Mutation_p.E137K|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.E232K|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	249						integral to membrane	receptor activity			breast(1)	1						GGAAGAAATTGAACCTTTGCC	0.383													11	91					0	0	0	0	A	60183186	A	A	60183186	3	1	70	1	0	0	0	0	1	0	0	0	9911	1291	45	2	763	2	MS4A14	11	60183186	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	68	60183186	74823330	246	14400											
AHNAK	79026	broad.mit.edu	37	chr11	62287084	62287084	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttcaccaccttctaacttCggacctgaaaatccaatttt	12	13	3	13	1	2	1	1	1	1	0	4	2	3	2	4	1	1	0	4	1	4	6	rs149805243		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:62287084C>T	uc001ntl.2	-	5	15105	c.14805G>A	c.(14803-14805)CCG>CCA	p.P4935P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4935					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTTCTAACTTCGGACCTGAAA	0.458													24	118					0	0	0	0	T	62287084	T	T	62287084	2	4	70	1	0	0	0	0	0	0	0	1	414	871	31	1		1	AHNAK	11	62287084	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2103898	62287084	72719432	247	14401											
COX8A	1351	broad.mit.edu	37	chr11	63743743	63743743	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcgtgaccttcctcctgcCagcgggctggatcctgtcac	4	11	10	16	2	1	1	1	1	0	0	5	2	4	2	5	2	2	1	5	2	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:63743743C>T	uc001nye.2	+	2	235	c.161C>T	c.(160-162)CCA>CTA	p.P54L		NM_004074	NP_004065	P10176	COX8A_HUMAN	cytochrome c oxidase subunit VIIIa precursor	54	Helical; (By similarity).				respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	cytochrome-c oxidase activity				0						TTCCTCCTGCCAGCGGGCTGG	0.597													100	135					0	0	0	0	T	63743743	T	T	63743743	3	4	70	1	0	0	0	0	1	0	0	0	3800	594	21	4	167	4	COX8A	11	63743743	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1456659	63743743	71262773	248	14402											
SCYL1	57410	broad.mit.edu	37	chr11	65293810	65293810	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacagcagtggcagagtggtCagagagaagtggtgggtgac	11	6	19	5	0	1	4	1	1	0	3	1	6	1	4	0	4	1	2	0	4	1	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:65293810C>T	uc001oea.1	+	4	668	c.591C>T	c.(589-591)GTC>GTT	p.V197V	SCYL1_uc009yqk.2_Silent_p.V197V|SCYL1_uc001oeb.1_Silent_p.V197V|SCYL1_uc001oec.1_Silent_p.V197V|SCYL1_uc001oed.1_Silent_p.V54V	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	197	Protein kinase.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						GCAGAGTGGTCAGAGAGAAGT	0.662													5	33					0	0	0	0	T	65293810	T	T	65293810	2	4	70	1	0	0	0	0	0	0	0	1	14012	813	29	2		2	SCYL1	11	65293810	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1550067	65293810	69712706	249	14403											
ACTN3	89	broad.mit.edu	37	chr11	66328070	66328070	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgacagcgcacgatcagttCaaggcaacactgcccgaggc	11	5	11	14	3	2	1	2	1	0	0	2	3	2	1	1	2	3	3	1	2	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:66328070C>G	uc001oio.1	+	15	1722	c.1704C>G	c.(1702-1704)TTC>TTG	p.F568L	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	568	Spectrin 3.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						ACGATCAGTTCAAGGCAACAC	0.547													19	37					0	0	0	0	G	66328070	G	G	66328070	3	3	70	1	0	0	0	0	1	0	0	0	206	825	29	2	1762	2	ACTN3	11	66328070	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1034260	66328070	68678446	250	14404											
LRP5	4041	broad.mit.edu	37	chr11	68179074	68179074	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggacaccaacatgatcgagtCgtccaacatgctgggtgagg	11	7	13	10	2	0	2	0	2	0	0	3	4	1	3	2	3	3	1	2	3	2	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:68179074C>T	uc001ont.2	+	11	2564	c.2489C>T	c.(2488-2490)TCG>TTG	p.S830L	LRP5_uc009ysg.2_Missense_Mutation_p.S240L	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	830	LDL-receptor class B 14.|Beta-propeller 3.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						ATGATCGAGTCGTCCAACATG	0.657													5	56					0	0	0	0	T	68179074	T	T	68179074	3	4	70	1	0	0	0	0	1	0	0	0	9010	893	31	1	2531	1	LRP5	11	68179074	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1851004	68179074	66827442	251	14405											
ANO1	55107	broad.mit.edu	37	chr11	70028776	70028776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accccctggacctgggctacGaggtgcagatctgcaggtac	8	7	13	13	1	1	1	0	0	1	1	1	3	1	2	3	4	4	4	3	4	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:70028776G>A	uc001opj.2	+	24	2877	c.2572G>A	c.(2572-2574)GAG>AAG	p.E858K	ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.E567K|ANO1_uc010rql.1_Missense_Mutation_p.E32K	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	858	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CCTGGGCTACGAGGTGCAGAT	0.587													7	183					0	0	0	0	A	70028776	A	A	70028776	3	1	70	1	0	0	0	0	1	0	0	0	695	1059	37	1	2666	1	ANO1	11	70028776	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1849702	70028776	64977740	252	14406											
PGR	5241	broad.mit.edu	37	chr11	100933223	100933223	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tactgaaagaagttgcctctCgcctagttgattaagacttg	11	13	9	8	1	1	4	0	2	1	2	2	4	1	4	2	0	2	2	2	0	5	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:100933223C>T	uc001pgh.2	-	4	2910	c.2167G>A	c.(2167-2169)GAG>AAG	p.E723K	PGR_uc001pgg.2_Missense_Mutation_p.E104K|PGR_uc001pgi.2_Intron|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	723	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	AGTTGCCTCTCGCCTAGTTGA	0.358													26	56					0	0	0	0	T	100933223	T	T	100933223	3	4	70	1	0	0	0	0	1	0	0	0	11860	893	31	1	654	1	PGR	11	100933223	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	30904447	100933223	34073293	253	14407											
RNF214	257160	broad.mit.edu	37	chr11	117110556	117110556	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcagaggtaaacacagatCaagatattgaaaagaatttg	19	10	8	4	0	2	5	2	1	0	4	2	5	2	5	0	1	1	1	0	1	7	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:117110556C>T	uc001pqt.2	+	4	703	c.658C>T	c.(658-660)CAA>TAA	p.Q220*	RNF214_uc001pqu.2_Nonsense_Mutation_p.Q220*|RNF214_uc010rxf.1_Nonsense_Mutation_p.Q65*	NM_207343	NP_997226	Q8ND24	RN214_HUMAN	ring finger protein 214	220	Potential.						zinc ion binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		AAACACAGATCAAGATATTGA	0.318													6	17					0	0	0	0	T	117110556	T	T	117110556	4	4	70	1	0	0	0	0	0	1	0	0	13543	827	29	2	668	2	RNF214	11	117110556	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	16177333	117110556	17895960	254	14408											
CACNA1C	775	broad.mit.edu	37	chr12	2693722	2693722	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggacaacctggctgatgctGagagcctcacatctgcccaa	10	8	10	13	0	2	2	1	2	1	1	2	4	2	3	3	2	4	2	3	2	2	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:2693722G>A	uc009zdu.1	+	16	2591	c.2278G>A	c.(2278-2280)GAG>AAG	p.E760K	CACNA1C_uc009zdv.1_Missense_Mutation_p.E757K|CACNA1C_uc001qkb.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkc.2_Missense_Mutation_p.E760K|CACNA1C_uc001qke.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkf.2_Missense_Mutation_p.E760K|CACNA1C_uc001qjz.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkd.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkg.2_Missense_Mutation_p.E760K|CACNA1C_uc009zdw.1_Missense_Mutation_p.E760K|CACNA1C_uc001qkh.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkl.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkn.2_Missense_Mutation_p.E760K|CACNA1C_uc001qko.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkp.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkr.2_Missense_Mutation_p.E760K|CACNA1C_uc001qku.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkq.2_Missense_Mutation_p.E760K|CACNA1C_uc001qks.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkt.2_Missense_Mutation_p.E760K|CACNA1C_uc001qka.1_Missense_Mutation_p.E295K|CACNA1C_uc001qki.1_Missense_Mutation_p.E496K|CACNA1C_uc001qkj.1_Missense_Mutation_p.E496K|CACNA1C_uc001qkk.1_Missense_Mutation_p.E496K|CACNA1C_uc001qkm.1_Missense_Mutation_p.E496K|CACNA1C_uc001qkw.2_Missense_Mutation_p.E49K	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	760	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGCTGATGCTGAGAGCCTCAC	0.433													13	45					0	0	0	0	A	2693722	A	A	2693722	3	1	70	1	0	0	0	0	1	0	0	0	2552	1291	45	2	2448	2	CACNA1C	12	2693722	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08		2693722	131158173	255	14409											
CASC1	55259	broad.mit.edu	37	chr12	25274696	25274696	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcaacctacttccacaatCatccatcccttcactggttt	11	13	2	15	0	3	0	3	0	0	0	6	0	6	0	4	1	2	1	4	1	4	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:25274696C>T	uc001rgl.2	-	10	1294	c.1212G>A	c.(1210-1212)ATG>ATA	p.M404I	CASC1_uc001rgk.2_Missense_Mutation_p.M410I|CASC1_uc001rgm.3_Missense_Mutation_p.M468I|CASC1_uc001rgj.2_Missense_Mutation_p.M364I|CASC1_uc010sje.1_Missense_Mutation_p.M345I|CASC1_uc010sjf.1_Missense_Mutation_p.M292I|CASC1_uc010sjg.1_Missense_Mutation_p.M404I	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	404										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			CTTCCACAATCATCCATCCCT	0.353													22	46					0	0	0	0	T	25274696	T	T	25274696	3	4	70	1	0	0	0	0	1	0	0	0	2672	826	29	2	962	2	CASC1	12	25274696	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	22580974	25274696	108577199	256	14410											
DENND5B	160518	broad.mit.edu	37	chr12	31555438	31555438	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttagctgaacctacctcaaaGgtcatttcgaggaggttttt	10	14	9	8	1	2	1	2	1	0	0	3	3	2	2	2	3	3	2	2	3	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:31555438G>T	uc001rki.1	-	15	3129	c.2943C>A	c.(2941-2943)ACC>ACA	p.T981T	DENND5B_uc001rkh.1_Silent_p.T1016T|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	981	PLAT.					integral to membrane				ovary(1)|central_nervous_system(1)	2						CTACCTCAAAGGTCATTTCGA	0.398													39	46					2.47872e-24	2.70257e-24	1	0	T	31555438	T	T	31555438	2	4	70	1	0	0	0	0	0	0	0	1	4459	987	35	4		4	DENND5B	12	31555438	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	6280742	31555438	102296457	257	14411											
LRRK2	120892	broad.mit.edu	37	chr12	40689444	40689444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctttccacaacagctatgtGaagtaaatttaatttatcct	13	15	5	8	0	0	1	0	1	0	0	2	1	2	1	2	0	2	3	2	0	7	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:40689444G>A	uc001rmg.3	+	23	3215	c.3094G>A	c.(3094-3096)GAA>AAA	p.E1032K	LRRK2_uc001rmh.1_Missense_Mutation_p.E654K|LRRK2_uc009zjw.2_5'UTR	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1032	LRR 2.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ACAGCTATGTGAAGTAAATTT	0.343													5	29					0	0	0	0	A	40689444	A	A	40689444	3	1	70	1	0	0	0	0	1	0	0	0	9083	1291	45	2	3184	2	LRRK2	12	40689444	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	9134006	40689444	93162451	258	14412											
PDZRN4	29951	broad.mit.edu	37	chr12	41967475	41967475	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgccgtgagttcatgatgcGaagcaggttagagtgtctca	9	11	13	8	3	2	3	2	2	1	1	4	4	2	3	1	1	2	3	1	1	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:41967475G>A	uc010skn.1	+	10	2365	c.2297G>A	c.(2296-2298)CGA>CAA	p.R766Q	PDZRN4_uc001rmq.3_Missense_Mutation_p.R707Q|PDZRN4_uc009zjz.2_Missense_Mutation_p.R705Q|PDZRN4_uc001rmr.2_Missense_Mutation_p.R592Q	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	965							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTCATGATGCGAAGCAGGTTA	0.507													12	32					0	0	0	0	A	41967475	A	A	41967475	3	1	70	1	0	0	0	0	1	0	0	0	11764	1058	37	1	3005	1	PDZRN4	12	41967475	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1278031	41967475	91884420	259	14413											
MLL2	8085	broad.mit.edu	37	chr12	49436553	49436559	+	Frame_Shift_Del	DEL	CGGCTGC	-	-																															agggcctctgcagtggcgtaCggctgccttctaggccaggg																										TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:49436553_49436559delCGGCTGC	uc001rta.3	-	26	5747_5753	c.5747_5753delGCAGCCG	c.(5746-5754)GGCAGCCGTfs	p.G1916fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1916_1918					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CAGTGGCGTACGGCTGCCTTCTAGGCC	0.546			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								-	49436559	-	-	49436553	7	5	70	1	0	1	0	1	0	0	0	0	9674	536	19	0	10976	0	MLL2	12	49436553	Frame_Shift_Del	DEL	CGGCTGC	TCGA-CN-6011-01A-11D-1683-08	7469078	49436553	84415342	260	14414											
MLL2	8085	broad.mit.edu	37	chr12	49436573	49436573	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggctgccttctaggccaggGgttccacaacccagatgctg	7	8	12	14	1	1	1	0	0	1	1	2	1	2	1	4	4	3	3	4	4	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:49436573G>T	uc001rta.3	-	26	5733	c.5733C>A	c.(5731-5733)ACC>ACA	p.T1911T		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1911					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTAGGCCAGGGGTTCCACAAC	0.542			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			24	58					1.66031e-10	1.76363e-10	1	0	T	49436573	T	T	49436573	2	4	70	1	0	0	0	0	0	0	0	1	9674	1219	43	4		4	MLL2	12	49436573	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	20	49436573	84415322	261	14415											
OR6C74	254783	broad.mit.edu	37	chr12	55641287	55641287	+	Frame_Shift_Del	DEL	A	-	-																															tttttagaagtctcattcacAactgtctacattcccaaatt																										TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:55641287delA	uc010spg.1	+	1	216	c.216delA	c.(214-216)ACAfs	p.T72fs		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TCTCATTCACAACTGTCTACA	0.393													---	---	---								-	55641287	-	-	55641287	7	5	70	1	0	1	0	1	0	0	0	0	11252	117	5	0	218	0	OR6C74	12	55641287	Frame_Shift_Del	DEL	A	TCGA-CN-6011-01A-11D-1683-08	6204714	55641287	78210608	262	14416											
METTL1	4234	broad.mit.edu	37	chr12	58163602	58163602	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgcttcatggcattgctacGgagacaggcgatgttctgga	8	11	14	8	2	2	1	1	0	1	1	2	4	2	2	0	4	3	4	0	4	1	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:58163602G>A	uc010ssd.1	-	3	460	c.412C>T	c.(412-414)CGT>TGT	p.R138C	CYP27B1_uc001spz.1_5'Flank|CYP27B1_uc001sqa.1_5'Flank|METTL1_uc009zqc.2_Intron|FAM119B_uc001sqf.2_5'Flank|FAM119B_uc001sqg.2_5'Flank|FAM119B_uc009zqd.2_5'Flank	NM_005371	NP_005362	Q9UBP6	TRMB_HUMAN	methyltransferase-like protein 1 isoform a	138						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding				0	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			GCATTGCTACGGAGACAGGCG	0.607													7	31					0	0	0	0	A	58163602	A	A	58163602	3	1	70	1	0	0	0	0	1	0	0	0	9546	1116	39	1	434	1	METTL1	12	58163602	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2522315	58163602	75688293	263	14417											
SRGAP1	57522	broad.mit.edu	37	chr12	64383777	64383777	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaaagaccatgcaaccttGagtgacatctatctgaacaa	16	8	7	10	0	2	4	0	3	2	1	2	4	2	4	2	0	4	2	2	0	5	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:64383777G>C	uc010ssp.1	+	3	407	c.351G>C	c.(349-351)TTG>TTC	p.L117F	SRGAP1_uc001srt.2_Missense_Mutation_p.L117F|SRGAP1_uc001srv.2_Missense_Mutation_p.L77F	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	117					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		ATGCAACCTTGAGTGACATCT	0.423													28	63					0	0	0	0	C	64383777	C	C	64383777	3	2	70	1	0	0	0	0	1	0	0	0	15211	1281	45	2	361	2	SRGAP1	12	64383777	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	6220175	64383777	69468118	264	14418											
DDX54	79039	broad.mit.edu	37	chr12	113599751	113599751	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgctctctgtcttaatcttCttcttgtcttcctgtcctga	3	19	5	14	1	6	1	0	1	6	0	9	1	8	1	3	0	0	1	3	0	1	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:113599751C>G	uc001tup.2	-	18	2275	c.2247G>C	c.(2245-2247)AAG>AAC	p.K749N	DDX54_uc001tuq.3_Missense_Mutation_p.K749N	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	749					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						TCTTAATCTTCTTCTTGTCTT	0.602													40	100					0	0	0	0	G	113599751	G	G	113599751	3	3	70	1	0	0	0	0	1	0	0	0	4389	912	32	2	413	2	DDX54	12	113599751	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	49215974	113599751	20252144	265	14419											
RNF10	9921	broad.mit.edu	37	chr12	120995255	120995255	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttacagttctgtgcataaGaaggatctcaagaggtgaga	13	11	12	5	0	2	3	1	1	2	3	3	5	2	4	0	2	2	3	0	2	4	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:120995255G>C	uc001typ.3	+	5	1299	c.816G>C	c.(814-816)AAG>AAC	p.K272N	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.K178N	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	272					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTGTGCATAAGAAGGATCTCA	0.443													34	81					0	0	0	0	C	120995255	C	C	120995255	3	2	70	1	0	0	0	0	1	0	0	0	13487	933	33	2	834	2	RNF10	12	120995255	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	7395504	120995255	12856640	266	14420											
RNF10	9921	broad.mit.edu	37	chr12	120995384	120995384	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtcacatcagtatgttgttgGtgataccattacgatgcagc	10	13	10	8	1	2	1	2	1	0	0	2	2	2	1	1	1	4	4	1	1	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:120995384G>A	uc001typ.3	+	6	1349	c.866G>A	c.(865-867)GGT>GAT	p.G289D	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.G195D	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	289					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TATGTTGTTGGTGATACCATT	0.448													31	109					0	0	0	0	A	120995384	A	A	120995384	3	1	70	1	0	0	0	0	1	0	0	0	13487	1261	44	4	888	4	RNF10	12	120995384	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	129	120995384	12856511	267	14421											
NCOR2	9612	broad.mit.edu	37	chr12	124957522	124957522	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttcttcagcttagagatCtgctgctctaccatggtgat	7	16	8	10	0	5	2	1	1	4	1	5	3	5	2	1	1	4	3	1	1	2	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:124957522C>T	uc010tba.1	-	4	684	c.567G>A	c.(565-567)CAG>CAA	p.Q189Q	NCOR2_uc010tay.1_Silent_p.Q189Q|NCOR2_uc010taz.1_Silent_p.Q189Q|NCOR2_uc010tbb.1_Silent_p.Q189Q|NCOR2_uc010tbc.1_Silent_p.Q189Q|NCOR2_uc001ugj.1_Silent_p.Q189Q|NCOR2_uc001ugk.1_Silent_p.Q189Q	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	189	Potential.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCTTAGAGATCTGCTGCTCTA	0.577													30	77					0	0	0	0	T	124957522	T	T	124957522	2	4	70	1	0	0	0	0	0	0	0	1	10290	912	32	2		2	NCOR2	12	124957522	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3962138	124957522	8894373	268	14422											
SLC15A4	121260	broad.mit.edu	37	chr12	129293444	129293444	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcgaccagtttgtccttcaGagggatgagcaggaggatga	11	9	14	7	1	1	3	1	2	0	1	3	7	2	6	2	3	1	2	2	3	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:129293444G>C	uc001uhu.2	-	5	1200	c.1147C>G	c.(1147-1149)CTG>GTG	p.L383V	SLC15A4_uc001uhv.2_RNA	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	solute carrier family 15, member 4	383	Helical; (Potential).				oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		TTGTCCTTCAGAGGGATGAGC	0.557													19	67					0	0	0	0	C	129293444	C	C	129293444	3	2	70	1	0	0	0	0	1	0	0	0	14466	933	33	2	602	2	SLC15A4	12	129293444	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	4335922	129293444	4558451	269	14423											
RIMBP2	23504	broad.mit.edu	37	chr12	130926553	130926553	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgtacctggcggccttgacGatgtcgaactcctcctcgtt	5	13	10	13	4	0	1	0	1	0	0	4	3	2	1	4	2	2	2	4	2	2	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:130926553G>A	uc001uil.2	-	8	1457	c.1293C>T	c.(1291-1293)ATC>ATT	p.I431I	RIMBP2_uc001uim.2_Silent_p.I339I|RIMBP2_uc001uin.1_Silent_p.I90I	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	431	Fibronectin type-III 2.					cell junction|synapse		p.I431I(1)		upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CGGCCTTGACGATGTCGAACT	0.567													11	51					0	0	0	0	A	130926553	A	A	130926553	2	1	70	1	0	0	0	0	0	0	0	1	13428	1048	37	1		1	RIMBP2	12	130926553	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1633109	130926553	2925342	270	14424											
XPO4	64328	broad.mit.edu	37	chr13	21417053	21417053	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	taatttggaggaagaaagttCcagctcaagacttgattggc	13	11	11	6	0	1	3	1	1	0	2	2	5	2	5	1	3	1	2	1	3	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:21417053C>G	uc001unq.3	-	6	744	c.708G>C	c.(706-708)TGG>TGC	p.W236C	XPO4_uc010tcr.1_Missense_Mutation_p.W162C	NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	236					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		GAAGAAAGTTCCAGCTCAAGA	0.408													7	20					0	0	0	0	G	21417053	G	G	21417053	3	3	70	1	0	0	0	0	1	0	0	0	17514	856	30	2	2819	2	XPO4	13	21417053	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08		21417053	93752825	271	14425											
MTUS2	23281	broad.mit.edu	37	chr13	29599371	29599371	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggaggcattctttggaaaGagcaagcagctctgtagctg	11	9	14	7	0	2	1	0	0	2	1	2	4	2	3	0	3	4	6	0	3	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:29599371G>C	uc001usl.3	+	1	624	c.566G>C	c.(565-567)AGA>ACA	p.R189T		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	179						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TCTTTGGAAAGAGCAAGCAGC	0.547													22	42					0	0	0	0	C	29599371	C	C	29599371	3	2	70	1	0	0	0	0	1	0	0	0	10019	942	33	2	568	2	MTUS2	13	29599371	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	8182318	29599371	85570507	272	14426											
KL	9365	broad.mit.edu	37	chr13	33627907	33627907	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtttttctcttcataggctCatgccaaagtctggcatctc	7	15	8	11	0	5	0	2	0	3	0	7	0	5	0	1	3	1	3	1	3	2	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:33627907C>T	uc001uus.2	+	2	831	c.823C>T	c.(823-825)CAT>TAT	p.H275Y	KL_uc001uur.1_5'UTR	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	275	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TTCATAGGCTCATGCCAAAGT	0.413													19	49					0	0	0	0	T	33627907	T	T	33627907	3	4	70	1	0	0	0	0	1	0	0	0	8370	826	29	2	829	2	KL	13	33627907	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	4028536	33627907	81541971	273	14427											
KL	9365	broad.mit.edu	37	chr13	33638296	33638296	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcccttatattttactactcGaagaaaggcagaagaagtta	15	12	7	7	1	0	3	0	0	0	3	2	4	1	3	1	1	2	2	1	1	9	6	rs139874106		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:33638296G>A	uc001uus.2	+	5	3020	c.3012G>A	c.(3010-3012)TCG>TCA	p.S1004S		NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	1004	Cytoplasmic (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TTTACTACTCGAAGAAAGGCA	0.333													9	14					0	0	0	0	A	33638296	A	A	33638296	2	1	70	1	0	0	0	0	0	0	0	1	8370	1045	37	1		1	KL	13	33638296	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	10389	33638296	81531582	274	14428											
RBM26	64062	broad.mit.edu	37	chr13	79911235	79911235	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgttgagcagtaagaaagtAccgcaaaatgaggaagaaga	18	7	12	4	1	0	5	0	2	0	3	0	6	0	6	1	1	2	5	1	1	7	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:79911235A>G	uc001vkz.2	-	19	2753	c.2739_splice	c.e19+1	p.A913_splice	RBM26_uc001vky.2_Splice_Site_p.A884_splice|RBM26_uc001vla.2_Splice_Site_p.A887_splice|RBM26_uc010tia.1_Splice_Site_p.A268_splice|RBM26_uc001vkx.2_Splice_Site_p.A623_splice	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26						mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GTAAGAAAGTACCGCAAAATG	0.413													9	3					0	0	0	0	G	79911235	G	G	79911235	5	3	70	1	0	0	0	0	0	0	1	0	13191	405	14	5	304	5	RBM26	13	79911235	Splice_Site	SNP	A	TCGA-CN-6011-01A-11D-1683-08	46272939	79911235	35258643	275	14429											
MYO16	23026	broad.mit.edu	37	chr13	109540724	109540724	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctctgttttccttagtggaGaaaggggatcaggaaagtct	10	13	12	6	0	3	1	1	0	2	1	5	4	4	3	1	4	0	1	1	4	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:109540724G>C	uc001vqt.1	+	14	1618	c.1492G>C	c.(1492-1494)GAA>CAA	p.E498Q	MYO16_uc010agk.1_Missense_Mutation_p.E520Q|MYO16_uc001vqu.1_Missense_Mutation_p.E298Q|MYO16_uc010tjh.1_Missense_Mutation_p.E10Q	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	498	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCTTAGTGGAGAAAGGGGATC	0.438													34	14					0	0	0	0	C	109540724	C	C	109540724	3	2	70	1	0	0	0	0	1	0	0	0	10117	943	33	2	1542	2	MYO16	13	109540724	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	29629489	109540724	5629154	276	14430											
OR4K5	79317	broad.mit.edu	37	chr14	20388770	20388770	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgcagcttggaaccatggAtaagtccaattcttcagtgg	10	13	10	8	0	2	0	1	0	1	0	3	2	3	2	2	3	3	2	2	3	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:20388770A>G	uc010tkw.1	+	1	5	c.5A>G	c.(4-6)GAT>GGT	p.D2G		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGAACCATGGATAAGTCCAAT	0.353													8	41					0	0	0	0	G	20388770	G	G	20388770	3	3	70	1	0	0	0	0	1	0	0	0	11127	333	12	5	7	5	OR4K5	14	20388770	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08		20388770	86960770	277	14431											
G2E3	55632	broad.mit.edu	37	chr14	31081542	31081542	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atatgttagtaaaagacataCttggctaccatgtaattcag	15	13	7	6	0	1	1	1	0	0	1	1	1	1	1	1	1	2	4	1	1	7	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:31081542C>G	uc001wqk.2	+	13	1784	c.1630C>G	c.(1630-1632)CTT>GTT	p.L544V	G2E3_uc010tpf.1_Missense_Mutation_p.L498V|G2E3_uc001wql.1_Missense_Mutation_p.L56V	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	544	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						AAAAGACATACTTGGCTACCA	0.299													20	46					0	0	0	0	G	31081542	G	G	31081542	3	3	70	1	0	0	0	0	1	0	0	0	6174	565	20	4	1676	4	G2E3	14	31081542	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	10692772	31081542	76267998	278	14432											
STRN3	29966	broad.mit.edu	37	chr14	31405711	31405711	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taattcctactttatgtttaTtcatccgatgtttgtctttt	7	23	4	7	1	2	0	1	0	1	0	4	1	4	0	2	0	1	2	2	0	4	11			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:31405711T>C	uc001wqu.2	-	6	1052	c.836A>G	c.(835-837)AAT>AGT	p.N279S	STRN3_uc001wqv.2_Missense_Mutation_p.N279S|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	279					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TTTATGTTTATTCATCCGATG	0.328													16	27					0	0	0	0	C	31405711	C	C	31405711	3	2	70	1	0	0	0	0	1	0	0	0	15396	1493	52	5	1609	5	STRN3	14	31405711	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	324169	31405711	75943829	279	14433											
TRIM9	114088	broad.mit.edu	37	chr14	51561183	51561183	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccgcggctttgctctgctGgtagcggtcaattacccctt	4	12	12	13	3	2	0	1	0	1	0	2	0	2	0	3	4	4	4	3	4	3	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:51561183G>A	uc001wyx.3	-	1	1240	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	TRIM9_uc001wyy.2_Nonsense_Mutation_p.Q159*|TRIM9_uc001wyz.3_Nonsense_Mutation_p.Q159*	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1	159					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					TTGCTCTGCTGGTAGCGGTCA	0.617													11	28					0	0	0	0	A	51561183	A	A	51561183	4	1	70	1	0	0	0	0	0	1	0	0	16616	1357	47	4	1747	4	TRIM9	14	51561183	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	20155472	51561183	55788357	280	14434											
RHOJ	57381	broad.mit.edu	37	chr14	63749901	63749901	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatatgaaagagaaacctctCacttacgagcatggtgtgaa	15	10	9	7	1	1	3	1	2	1	1	2	5	1	3	1	1	3	1	1	1	6	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:63749901C>T	uc001xgb.1	+	4	908	c.465C>T	c.(463-465)CTC>CTT	p.L155L		NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	ras homolog gene family, member J precursor	155					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		AGAAACCTCTCACTTACGAGC	0.398													17	36					0	0	0	0	T	63749901	T	T	63749901	2	4	70	1	0	0	0	0	0	0	0	1	13406	813	29	2		2	RHOJ	14	63749901	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	12188718	63749901	43599639	281	14435											
SYNE2	23224	broad.mit.edu	37	chr14	64564771	64564771	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaaaccttcaccagcatttGaagcaagaacaagaaggagt	17	7	8	9	0	1	3	1	1	0	2	1	4	1	4	2	1	4	2	2	1	7	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:64564771G>C	uc001xgm.2	+	62	12443	c.12213G>C	c.(12211-12213)TTG>TTC	p.L4071F	SYNE2_uc001xgl.2_Missense_Mutation_p.L4071F|SYNE2_uc010apy.2_Missense_Mutation_p.L456F|SYNE2_uc010apx.1_Missense_Mutation_p.L463F|MIR548H-1_hsa-mir-548h-1|MI0006411_5'Flank|SYNE2_uc010apz.1_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4071	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ACCAGCATTTGAAGCAAGAAC	0.473													6	73					0	0	0	0	C	64564771	C	C	64564771	3	2	70	1	0	0	0	0	1	0	0	0	15512	1281	45	2	12455	2	SYNE2	14	64564771	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	814870	64564771	42784769	282	14436											
ARG2	384	broad.mit.edu	37	chr14	68086772	68086772	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagaaatccgtccactccgtGgctgtgataggagccccgtt	9	9	11	12	3	0	2	0	1	0	1	3	3	3	3	5	2	1	2	5	2	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:68086772G>A	uc001xjs.2	+	1	194	c.78G>A	c.(76-78)GTG>GTA	p.V26V		NM_001172	NP_001163	P78540	ARGI2_HUMAN	arginase 2 precursor	26					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding				0				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	TCCACTCCGTGGCTGTGATAG	0.622													8	15					0	0	0	0	A	68086772	A	A	68086772	2	1	70	1	0	0	0	0	0	0	0	1	858	1335	47	4		4	ARG2	14	68086772	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3522001	68086772	39262768	283	14437											
FCF1	51077	broad.mit.edu	37	chr14	75181623	75181623	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaagaaaagaaggatccCagcgcattaaaggaaagaga	22	3	11	5	1	0	4	0	0	0	4	1	7	1	6	1	2	1	1	1	2	8	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:75181623C>G	uc001xqh.2	+	3	171	c.120C>G	c.(118-120)CCC>CCG	p.P40P	KIAA0317_uc001xqb.2_5'Flank|KIAA0317_uc010tut.1_5'Flank|KIAA0317_uc001xqc.2_5'Flank|KIAA0317_uc001xqd.1_5'Flank|FCF1_uc001xqe.1_RNA|FCF1_uc001xqf.1_Silent_p.P25P|FCF1_uc001xqg.2_RNA|FCF1_uc001xqi.2_RNA	NM_015962	NP_057046	Q9Y324	FCF1_HUMAN	FCF1 small subunit	40					rRNA processing	nucleolus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0037)		AGAAGGATCCCAGCGCATTAA	0.353													5	7					0	0	0	0	G	75181623	G	G	75181623	2	3	70	1	0	0	0	0	0	0	0	1	5809	581	21	4		4	FCF1	14	75181623	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	7094851	75181623	32167917	284	14438											
DLST	1743	broad.mit.edu	37	chr14	75359641	75359641	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcagcacccatacccactCagatgccaccggtgccctcg	8	6	8	19	2	1	1	1	0	0	1	2	1	1	1	5	1	5	2	5	1	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:75359641C>T	uc001xqv.2	+	8	610	c.547C>T	c.(547-549)CAG>TAG	p.Q183*	DLST_uc001xqu.2_Nonsense_Mutation_p.Q95*|DLST_uc001xqt.2_Nonsense_Mutation_p.Q99*|DLST_uc010tuw.1_Nonsense_Mutation_p.Q97*|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Nonsense_Mutation_p.Q183*	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	183					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		CATACCCACTCAGATGCCACC	0.587													18	21					0	0	0	0	T	75359641	T	T	75359641	4	4	70	1	0	0	0	0	0	1	0	0	4591	827	29	2	577	2	DLST	14	75359641	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	178018	75359641	31989899	285	14439											
DLST	1743	broad.mit.edu	37	chr14	75361017	75361017	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccactcttactttcaggaGaaaatgaacaggatgcggca	13	10	9	9	1	2	2	1	1	1	1	3	4	3	3	1	3	3	1	1	3	4	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:75361017G>C	uc001xqv.2	+	10	738	c.675G>C	c.(673-675)GAG>GAC	p.E225D	DLST_uc001xqu.2_Missense_Mutation_p.E137D|DLST_uc001xqt.2_Missense_Mutation_p.E141D|DLST_uc010tuw.1_Missense_Mutation_p.E139D|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Missense_Mutation_p.E225D	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	225					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		ACTTTCAGGAGAAAATGAACA	0.473													47	83					0	0	0	0	C	75361017	C	C	75361017	3	2	70	1	0	0	0	0	1	0	0	0	4591	933	33	2	713	2	DLST	14	75361017	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1376	75361017	31988523	286	14440											
C14orf118	55668	broad.mit.edu	37	chr14	76621245	76621245	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatactccctggacctcatCaggccacggattgtgtgaat	10	10	10	11	1	2	1	2	1	0	0	3	4	3	3	3	3	1	0	3	3	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:76621245C>G	uc001xsh.2	+	2	625	c.539C>G	c.(538-540)TCA>TGA	p.S180*	C14orf118_uc001xsi.2_Nonsense_Mutation_p.S180*|C14orf118_uc001xsj.1_Nonsense_Mutation_p.S180*|C14orf118_uc001xsk.1_Nonsense_Mutation_p.S180*|C14orf118_uc001xsl.2_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	180										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		TGGACCTCATCAGGCCACGGA	0.483													6	19					0	0	0	0	G	76621245	G	G	76621245	4	3	70	1	0	0	0	0	0	1	0	0	1747	838	29	2	541	2	C14orf118	14	76621245	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1260228	76621245	30728295	287	14441											
C14orf145	145508	broad.mit.edu	37	chr14	81209426	81209426	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactaacacacacctctcttCtcacgatgtatttcatccag	12	12	3	14	1	3	0	2	0	2	0	6	1	4	0	2	0	2	1	2	0	3	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:81209426C>T	uc001xux.2	-	18	2970	c.2799G>A	c.(2797-2799)GAG>GAA	p.E933E	C14orf145_uc010asz.1_RNA	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	933	Potential.					centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		CACCTCTCTTCTCACGATGTA	0.378													18	86					0	0	0	0	T	81209426	T	T	81209426	2	4	70	1	0	0	0	0	0	0	0	1	1755	912	32	2		2	C14orf145	14	81209426	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	4588181	81209426	26140114	288	14442											
SEL1L	6400	broad.mit.edu	37	chr14	81952776	81952776	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctttcagaccaacggcctCgttcacatacattcttaaac	11	11	5	14	2	3	1	2	0	1	1	4	1	3	1	3	1	3	1	3	1	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:81952776C>T	uc010tvv.1	-	17	1772	c.1655G>A	c.(1654-1656)CGA>CAA	p.R552Q		NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	552	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Sel1-like 9.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		CCAACGGCCTCGTTCACATAC	0.413													34	106					0	0	0	0	T	81952776	T	T	81952776	3	4	70	1	0	0	0	0	1	0	0	0	14075	884	31	1	749	1	SEL1L	14	81952776	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	743350	81952776	25396764	289	14443											
SETD3	84193	broad.mit.edu	37	chr14	99932040	99932040	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcccagaggaggacttacTctgcagcagctcactggtca	10	7	12	12	0	3	1	2	0	1	1	3	4	3	3	1	3	5	3	1	3	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:99932040T>A	uc001ygc.2	-	2	273	c.103A>T	c.(103-105)AAA>TAA	p.K35*	SETD3_uc001ygd.2_Nonsense_Mutation_p.K35*|SETD3_uc001ygf.2_Nonsense_Mutation_p.K35*	NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	35					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				GAGGACTTACTCTGCAGCAGC	0.502													9	30					0	0	0	0	A	99932040	A	A	99932040	4	1	70	1	0	0	0	0	0	1	0	0	14197	1565	54	5	1775	5	SETD3	14	99932040	Nonsense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	17979264	99932040	7417500	290	14444											
EIF5	1983	broad.mit.edu	37	chr14	103807372	103807372	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acaacaaggatgacgacatcGatattgatgccatttaaagg	16	9	9	7	2	0	2	0	2	0	0	1	5	0	3	1	2	2	0	1	2	5	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:103807372G>C	uc001ymq.2	+	12	1801	c.1279G>C	c.(1279-1281)GAT>CAT	p.D427H	EIF5_uc001ymr.2_Missense_Mutation_p.D427H|EIF5_uc001yms.2_Missense_Mutation_p.D427H|EIF5_uc001ymt.2_Missense_Mutation_p.D427H|EIF5_uc001ymu.2_Missense_Mutation_p.D427H	NM_001969	NP_001960	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	427	Asp-rich (acidic).				regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			pancreas(1)|breast(1)|skin(1)	3		Melanoma(154;0.155)	Epithelial(46;0.182)			TGACGACATCGATATTGATGC	0.403													7	42					0	0	0	0	C	103807372	C	C	103807372	3	2	70	1	0	0	0	0	1	0	0	0	5064	1058	37	3	1317	3	EIF5	14	103807372	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3875332	103807372	3542168	291	14445											
SIVA1	10572	broad.mit.edu	37	chr14	105225821	105225821	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgccatgttcgagacctGaggctggctcaagccggctg	6	9	14	12	2	1	2	1	1	0	1	2	3	1	2	3	3	2	4	3	3	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:105225821G>A	uc001yph.2	+	4	596	c.527G>A	c.(526-528)TGA>TAA	p.*176*	INF2_uc010tyi.1_Intron|SIVA1_uc001ypg.1_3'UTR|SIVA1_uc001ypi.2_Silent_p.*111*	NM_006427	NP_006418	O15304	SIVA_HUMAN	CD27-binding (Siva) protein isoform 1	176					activation of caspase activity by cytochrome c|activation-induced cell death of T cells|apoptosis|induction of apoptosis|interspecies interaction between organisms|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity	cytoplasm|mitochondrion|nucleoplasm|nucleus	caspase activator activity|CD27 receptor binding|metal ion binding|viral receptor activity|zinc ion binding				0		all_cancers(154;0.14)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.173)		TTCGAGACCTGAGGCTGGCTC	0.597													4	23					0	0	0	0	A	105225821	A	A	105225821	2	1	70	1	0	0	0	0	0	0	0	1	14410	1285	45	2		2	SIVA1	14	105225821	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1418449	105225821	2123719	292	14446											
AKT1	207	broad.mit.edu	37	chr14	105241317	105241317	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgcaggacgcggttctcGgtgagtgtgtgggccacctc	4	11	15	11	3	2	1	0	1	2	0	4	2	2	2	2	4	1	2	2	4	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:105241317G>A	uc001ypk.2	-	7	1145	c.591C>T	c.(589-591)ACC>ACT	p.T197T	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Silent_p.T197T|AKT1_uc010axa.2_Silent_p.T197T|AKT1_uc001ypm.2_Silent_p.T197T|AKT1_uc001ypn.2_Silent_p.T197T|AKT1_uc010tyk.1_Silent_p.T135T	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	197	Protein kinase.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	CGCGGTTCTCGGTGAGTGTGT	0.682		1	Mis		breast|colorectal|ovarian|NSCLC								14	56					0	0	0	0	A	105241317	A	A	105241317	2	1	70	1	0	0	0	0	0	0	0	1	478	1103	39	1		1	AKT1	14	105241317	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	15496	105241317	2108223	293	14447											
TRPM1	4308	broad.mit.edu	37	chr15	31339443	31339443	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctgatgtggtaatcaggCggaaggttgctctgtaaaag	11	10	15	5	1	2	1	1	1	1	0	2	2	2	2	0	5	1	5	0	5	4	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:31339443C>T	uc001zfm.2	-	14	1697	c.1569G>A	c.(1567-1569)CCG>CCA	p.P523P	TRPM1_uc010azy.2_Silent_p.P430P|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	523	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GGTAATCAGGCGGAAGGTTGC	0.547													6	25					0	0	0	0	T	31339443	T	T	31339443	2	4	70	1	0	0	0	0	0	0	0	1	16652	755	27	1		1	TRPM1	15	31339443	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08		31339443	71191949	294	14448											
C15orf24	56851	broad.mit.edu	37	chr15	34382601	34382601	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctgaagatttcatttggaGaggatagggcagtctgacaa	13	10	12	6	0	2	4	1	2	1	2	2	6	2	5	1	3	0	1	1	3	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:34382601G>C	uc001zhm.2	-	3	425	c.412C>G	c.(412-414)CTC>GTC	p.L138V	C15orf24_uc001zhn.2_Missense_Mutation_p.L21V	NM_020154	NP_064539	Q9NPA0	CO024_HUMAN	chromosome 15 open reading frame 24 precursor	138	Extracellular (Potential).					cytoplasm|integral to membrane	carbohydrate binding|carboxypeptidase activity|purine nucleotide binding				0		all_lung(180;1.76e-08)		all cancers(64;2.02e-17)|GBM - Glioblastoma multiforme(113;2.15e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)		TTCATTTGGAGAGGATAGGGC	0.393													15	60					0	0	0	0	C	34382601	C	C	34382601	3	2	70	1	0	0	0	0	1	0	0	0	1792	942	33	2	328	2	C15orf24	15	34382601	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3043158	34382601	68148791	295	14449											
CASC5	57082	broad.mit.edu	37	chr15	40914964	40914964	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttagaggacgaaagtgtacaGaaacctaaatttccaaagga	18	8	9	6	1	0	2	0	0	0	2	1	5	1	4	2	2	2	1	2	2	7	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:40914964G>A	uc010bbs.1	+	11	2741	c.2580G>A	c.(2578-2580)CAG>CAA	p.Q860Q	CASC5_uc010ucq.1_Silent_p.Q684Q|CASC5_uc001zme.2_Silent_p.Q834Q|CASC5_uc010bbt.1_Silent_p.Q834Q	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	860	2 X 104 AA approximate repeats.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AAAGTGTACAGAAACCTAAAT	0.338													32	44					0	0	0	0	A	40914964	A	A	40914964	2	1	70	1	0	0	0	0	0	0	0	1	2675	933	33	2		2	CASC5	15	40914964	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	6532363	40914964	61616428	296	14450											
SPINT1	6692	broad.mit.edu	37	chr15	41148218	41148218	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acggcaacaagaacaactttGaggaagagcagcagtgcctc	15	5	11	10	1	0	3	0	1	0	2	1	4	0	4	1	2	6	3	1	2	5	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:41148218G>A	uc001zna.2	+	9	1498	c.1294G>A	c.(1294-1296)GAG>AAG	p.E432K	SPINT1_uc001znb.2_Missense_Mutation_p.E416K|SPINT1_uc001znc.2_Missense_Mutation_p.E416K|SPINT1_uc010ucs.1_Missense_Mutation_p.E423K	NM_181642	NP_857593	O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	432	BPTI/Kunitz inhibitor 2.					extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GAACAACTTTGAGGAAGAGCA	0.577													32	87					0	0	0	0	A	41148218	A	A	41148218	3	1	70	1	0	0	0	0	1	0	0	0	15134	1291	45	2	1324	2	SPINT1	15	41148218	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	233254	41148218	61383174	297	14451											
ZFP106	64397	broad.mit.edu	37	chr15	42742338	42742338	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaagccttctgtttcataaGatacatgagatttaatagag	15	13	7	6	0	2	3	1	1	1	3	2	4	2	3	1	0	2	1	1	0	5	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:42742338G>A	uc001zpw.2	-	2	2398	c.2063C>T	c.(2062-2064)TCT>TTT	p.S688F	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Missense_Mutation_p.S471F|ZFP106_uc001zpy.1_Missense_Mutation_p.S711F	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	688						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		TGTTTCATAAGATACATGAGA	0.453													34	103					0	0	0	0	A	42742338	A	A	42742338	3	1	70	1	0	0	0	0	1	0	0	0	17704	942	33	2	3660	2	ZFP106	15	42742338	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1594120	42742338	59789054	298	14452											
SERINC4	619189	broad.mit.edu	37	chr15	44087395	44087395	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttgatgaaggtcttttccaGttctgctccctcatagctgt	6	16	8	11	0	3	2	1	2	2	0	5	2	5	2	2	1	2	3	2	1	2	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:44087395G>T	uc010bds.1	-	9	1096	c.628C>A	c.(628-630)CTG>ATG	p.L210M	ELL3_uc001zsx.1_Intron|SERF2_uc010uee.1_3'UTR|C15orf63_uc001ztb.2_Intron|SERF2_uc001zsz.3_3'UTR|MIR1282_hsa-mir-1282|MI0006429_5'Flank|SERINC4_uc001ztc.1_RNA|SERINC4_uc001ztd.1_Missense_Mutation_p.N97K|SERINC4_uc001zte.1_Missense_Mutation_p.L210M	NM_001033517	NP_001028689	A6NH21	SERC4_HUMAN	serine incorporator 4	454					phospholipid biosynthetic process	integral to membrane					0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		GBM - Glioblastoma multiforme(94;7.81e-07)		GTCTTTTCCAGTTCTGCTCCC	0.507													11	33					2.27111e-07	2.39191e-07	1	0	T	44087395	T	T	44087395	3	4	70	1	0	0	0	0	1	0	0	0	14147	1020	36	4	200	4	SERINC4	15	44087395	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1345057	44087395	58443997	299	14453											
SLC30A4	7782	broad.mit.edu	37	chr15	45778943	45778943	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cattcaaatggcttggcacaCctattaggaatatataattt	14	14	6	7	0	1	0	1	0	0	0	1	1	1	1	1	3	0	2	1	3	7	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:45778943C>G	uc001zvj.2	-	7	1313	c.1001G>C	c.(1000-1002)GGT>GCT	p.G334A		NM_013309	NP_037441	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter),	334	Cytoplasmic (Potential).				regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity				0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)		GCTTGGCACACCTATTAGGAA	0.294													41	167					0	0	0	0	G	45778943	G	G	45778943	3	3	70	1	0	0	0	0	1	0	0	0	14621	521	18	4	296	4	SLC30A4	15	45778943	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1691548	45778943	56752449	300	14454											
TRPM7	54822	broad.mit.edu	37	chr15	50866575	50866575	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tagttggaataatctcatctCcattattattgttgtatttt	10	21	5	5	0	2	0	1	0	2	0	4	1	2	1	1	1	0	3	1	1	6	10			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:50866575C>G	uc001zyt.3	-	36	5468	c.5204G>C	c.(5203-5205)GGA>GCA	p.G1735A	TRPM7_uc001zyr.2_Missense_Mutation_p.G172A	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	1735	Cytoplasmic (Potential).|Alpha-type protein kinase.				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		AATCTCATCTCCATTATTATT	0.388													10	43					0	0	0	0	G	50866575	G	G	50866575	3	3	70	1	0	0	0	0	1	0	0	0	16658	855	30	2	409	2	TRPM7	15	50866575	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	5087632	50866575	51664817	301	14455											
TRPM7	54822	broad.mit.edu	37	chr15	50866605	50866605	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgttgtattttctaaattctCcagtcatacattcttccaca	10	18	3	10	0	4	0	1	0	3	0	6	0	5	0	2	0	1	2	2	0	4	9			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:50866605C>G	uc001zyt.3	-	36	5438	c.5174G>C	c.(5173-5175)GGA>GCA	p.G1725A	TRPM7_uc001zyr.2_Missense_Mutation_p.G162A	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	1725	Cytoplasmic (Potential).|Alpha-type protein kinase.				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TCTAAATTCTCCAGTCATACA	0.343													4	31					0	0	0	0	G	50866605	G	G	50866605	3	3	70	1	0	0	0	0	1	0	0	0	16658	855	30	2	439	2	TRPM7	15	50866605	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	30	50866605	51664787	302	14456											
DMXL2	23312	broad.mit.edu	37	chr15	51778300	51778300	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcatcctcctttggtgtttGttccagtaatgtgtccaagg	7	16	9	9	0	1	0	1	0	0	0	5	0	5	0	4	2	0	3	4	2	2	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:51778300G>C	uc002abf.2	-	23	5677	c.5452C>G	c.(5452-5454)CAA>GAA	p.Q1818E	DMXL2_uc010ufy.1_Missense_Mutation_p.Q1818E|DMXL2_uc010bfa.2_Missense_Mutation_p.Q1182E	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1818						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TTTGGTGTTTGTTCCAGTAAT	0.383													30	27					0	0	0	0	C	51778300	C	C	51778300	3	2	70	1	0	0	0	0	1	0	0	0	4617	1386	48	4	3745	4	DMXL2	15	51778300	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	911695	51778300	50753092	303	14457											
UNC13C	440279	broad.mit.edu	37	chr15	54305292	54305292	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttttaaaagcactgtaaaGaagattgcaaagtgttcatc	16	12	7	6	0	1	2	1	0	0	2	2	2	1	2	0	0	2	4	0	0	6	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:54305292G>T	uc002ack.2	+	1	192	c.192G>T	c.(190-192)AAG>AAT	p.K64N		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	64					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCACTGTAAAGAAGATTGCAA	0.423													9	47					0.00448238	0.00456539	1	0	T	54305292	T	T	54305292	3	4	70	1	0	0	0	0	1	0	0	0	17054	933	33	2	194	2	UNC13C	15	54305292	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2526992	54305292	48226100	304	14458											
UNC13C	440279	broad.mit.edu	37	chr15	54586136	54586136	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaatcaaagtcagagtatggGatgaagatgatgatattaaa	18	10	11	2	0	2	5	2	3	0	2	2	7	2	6	0	1	0	1	0	1	7	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:54586136G>A	uc002ack.2	+	9	3862	c.3862G>A	c.(3862-3864)GAT>AAT	p.D1288N	UNC13C_uc002acl.2_Missense_Mutation_p.D118N	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1288	C2 1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CAGAGTATGGGATGAAGATGA	0.358													31	29					0	0	0	0	A	54586136	A	A	54586136	3	1	70	1	0	0	0	0	1	0	0	0	17054	1174	41	2	3896	2	UNC13C	15	54586136	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	280844	54586136	47945256	305	14459											
PDCD7	10081	broad.mit.edu	37	chr15	65426079	65426079	+	Frame_Shift_Del	DEL	G	-	-																															gcggcggctgcgggggcggtGggcctgggcgaccctggccg																										TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:65426079delG	uc002aol.2	-	1	96	c.41delC	c.(40-42)CCAfs	p.P14fs		NM_005707	NP_005698	Q8N8D1	PDCD7_HUMAN	programmed cell death 7	14	Pro-rich.				apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex					0						CGGGGGCGGTGGGCCTGGGCG	0.692													---	---	---								-	65426079	-	-	65426079	7	5	70	1	0	1	0	1	0	0	0	0	11679	1348	47	0	1436	0	PDCD7	15	65426079	Frame_Shift_Del	DEL	G	TCGA-CN-6011-01A-11D-1683-08	10839943	65426079	37105313	306	14460											
CILP	8483	broad.mit.edu	37	chr15	65489097	65489097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaggggctgttgagcaactCtaggaaatctcagagaggcc	11	8	13	9	0	3	2	2	1	2	1	4	4	3	3	1	4	2	3	1	4	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:65489097C>T	uc002aon.2	-	9	3708	c.3527G>A	c.(3526-3528)AGA>AAA	p.R1176K		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	1176					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TTGAGCAACTCTAGGAAATCT	0.557													14	30					0	0	0	0	T	65489097	T	T	65489097	3	4	70	1	0	0	0	0	1	0	0	0	3444	913	32	2	31	2	CILP	15	65489097	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	63018	65489097	37042295	307	14461											
KIF23	9493	broad.mit.edu	37	chr15	69739225	69739225	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcagtgttctgtggctgtgGagatgagagcaggatcccag	8	10	15	8	0	2	2	1	1	1	2	3	5	3	3	1	3	1	3	1	3	0	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:69739225G>A	uc002asb.2	+	22	2929	c.2812G>A	c.(2812-2814)GAG>AAG	p.E938K	KIF23_uc002asc.2_Missense_Mutation_p.E834K|KIF23_uc010bii.2_Missense_Mutation_p.E744K|KIF23_uc010ukc.1_Missense_Mutation_p.E651K	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	938					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						TGTGGCTGTGGAGATGAGAGC	0.468													13	70					0	0	0	0	A	69739225	A	A	69739225	3	1	70	1	0	0	0	0	1	0	0	0	8330	1175	41	2	2898	2	KIF23	15	69739225	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	4250128	69739225	32792167	308	14462											
GOLGA6B	55889	broad.mit.edu	37	chr15	72953676	72953676	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaggagcgggcgctgctgaaCgcacacgtgacacaggtgag	11	4	16	10	4	0	3	0	3	0	0	0	4	0	4	0	3	3	3	0	3	2	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:72953676C>T	uc010uks.1	+	8	677	c.636C>T	c.(634-636)AAC>AAT	p.N212N		NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	212	Potential.										0						CGCTGCTGAACGCACACGTGA	0.582													9	43					0	0	0	0	T	72953676	T	T	72953676	2	4	70	1	0	0	0	0	0	0	0	1	6595	535	19	1		1	GOLGA6B	15	72953676	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3214451	72953676	29577716	309	14463											
CSPG4	1464	broad.mit.edu	37	chr15	75982533	75982533	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttccagccggtgagcattGatgtggacactgacctcatg	9	11	11	10	1	1	3	1	3	0	0	2	4	2	4	3	2	2	1	3	2	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:75982533G>A	uc002baw.2	-	3	966	c.873C>T	c.(871-873)ATC>ATT	p.I291I		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	291	Extracellular (Potential).|Neurite growth inhibition (By similarity).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						GGTGAGCATTGATGTGGACAC	0.617													12	34					0	0	0	0	A	75982533	A	A	75982533	2	1	70	1	0	0	0	0	0	0	0	1	3977	1280	45	2		2	CSPG4	15	75982533	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	3028857	75982533	26548859	310	14464											
ISL2	64843	broad.mit.edu	37	chr15	76634064	76634064	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtttccgccgccccaggtctCcttctccgagtccggctccc	2	10	9	20	4	2	0	0	0	2	0	7	1	5	0	8	2	0	2	8	2	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:76634064C>A	uc002bbw.1	+	6	1046	c.968C>A	c.(967-969)TCC>TAC	p.S323Y		NM_145805	NP_665804	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	323						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCCCAGGTCTCCTTCTCCGAG	0.677													13	66					1.3612e-06	1.42753e-06	1	0	A	76634064	A	A	76634064	3	1	70	1	0	0	0	0	1	0	0	0	7896	855	30	2	990	2	ISL2	15	76634064	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	651531	76634064	25897328	311	14465											
RASGRF1	5923	broad.mit.edu	37	chr15	79294085	79294085	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtatcaccatcatcactctGgttttgatcaatatctgact	11	15	5	10	0	6	2	4	2	2	0	6	2	6	2	1	1	0	2	1	1	3	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:79294085G>A	uc002beq.2	-	17	2917	c.2542C>T	c.(2542-2544)CAG>TAG	p.Q848*	RASGRF1_uc002bep.2_Nonsense_Mutation_p.Q832*|RASGRF1_uc010blm.1_Nonsense_Mutation_p.Q757*|RASGRF1_uc002ber.3_Nonsense_Mutation_p.Q832*|RASGRF1_uc010unh.1_Nonsense_Mutation_p.Q243*|RASGRF1_uc002beo.2_Nonsense_Mutation_p.Q64*	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	850					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						TCATCACTCTGGTTTTGATCA	0.308													47	58					0	0	0	0	A	79294085	A	A	79294085	4	1	70	1	0	0	0	0	0	1	0	0	13137	1357	47	4	1327	4	RASGRF1	15	79294085	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2660021	79294085	23237307	312	14466											
ST8SIA2	8128	broad.mit.edu	37	chr15	93007381	93007381	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agacccaccaccggcctcttGatgtataccctggccacacg	9	7	8	17	2	1	2	0	1	1	1	1	2	1	2	6	2	1	1	6	2	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:93007381G>C	uc002bra.2	+	6	1049	c.894G>C	c.(892-894)TTG>TTC	p.L298F	ST8SIA2_uc002brb.2_Missense_Mutation_p.L277F	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	298	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			CCGGCCTCTTGATGTATACCC	0.428													3	14					0	0	0	0	C	93007381	C	C	93007381	3	2	70	1	0	0	0	0	1	0	0	0	15298	1281	45	2	916	2	ST8SIA2	15	93007381	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	13713296	93007381	9524011	313	14467											
RUNDC2A	84127	broad.mit.edu	37	chr16	12145835	12145835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggcaggggagagctcagagGacaactccgaccgctcctct	9	5	14	13	2	2	2	1	0	1	2	4	5	4	3	3	4	2	3	3	4	1	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:12145835G>A	uc002dbw.1	+	8	942	c.880G>A	c.(880-882)GAC>AAC	p.D294N	SNX29_uc002dby.3_5'Flank	NM_032167	NP_115543	Q9HA26	RUN2A_HUMAN	RUN domain containing 2A	294										ovary(1)	1						GAGCTCAGAGGACAACTCCGA	0.483			T	CIITA	PMBL|Hodgkin Lymphona|								15	52					0	0	0	0	A	12145835	A	A	12145835	3	1	70	1	0	0	0	0	1	0	0	0	13808	1174	41	2	910	2	RUNDC2A	16	12145835	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08		12145835	78208918	314	14468											
MYH11	4629	broad.mit.edu	37	chr16	15833949	15833949	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcatccatgaccaggatctCatcctccagtttcttgatct	9	14	5	13	0	4	2	2	2	3	0	8	3	7	3	4	1	0	1	4	1	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:15833949C>T	uc002ddy.2	-	23	3063	c.2956G>A	c.(2956-2958)GAG>AAG	p.E986K	MYH11_uc002ddv.2_Missense_Mutation_p.E993K|MYH11_uc002ddw.2_Missense_Mutation_p.E986K|MYH11_uc002ddx.2_Missense_Mutation_p.E993K|MYH11_uc010bvg.2_Missense_Mutation_p.E818K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	986	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						ACCAGGATCTCATCCTCCAGT	0.363			T	CBFB	AML								28	78					0	0	0	0	T	15833949	T	T	15833949	3	4	70	1	0	0	0	0	1	0	0	0	10084	835	29	2	3073	2	MYH11	16	15833949	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3688114	15833949	74520804	315	14469											
MYH11	4629	broad.mit.edu	37	chr16	15841954	15841954	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggggaagccctgccggcaGatgcgaatgccttccagcac	8	7	13	13	2	0	1	0	0	0	1	1	3	1	2	4	3	5	2	4	3	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:15841954G>C	uc002ddy.2	-	17	2237	c.2130C>G	c.(2128-2130)ATC>ATG	p.I710M	MYH11_uc002ddv.2_Missense_Mutation_p.I717M|MYH11_uc002ddw.2_Missense_Mutation_p.I710M|MYH11_uc002ddx.2_Missense_Mutation_p.I717M|MYH11_uc010bvg.2_Missense_Mutation_p.I542M	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	710	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CCTGCCGGCAGATGCGAATGC	0.637			T	CBFB	AML								15	64					0	0	0	0	C	15841954	C	C	15841954	3	2	70	1	0	0	0	0	1	0	0	0	10084	932	33	2	3923	2	MYH11	16	15841954	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	8005	15841954	74512799	316	14470											
XYLT1	64131	broad.mit.edu	37	chr16	17221547	17221547	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaactgaagcctcccaaaGtcactgggtgggcttgcgat	11	8	12	10	1	1	1	1	1	0	0	2	3	2	1	2	2	3	1	2	2	4	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:17221547G>A	uc002dfa.2	-	10	2284	c.2199C>T	c.(2197-2199)GAC>GAT	p.D733D		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	733	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GCCTCCCAAAGTCACTGGGTG	0.483													114	93					0	0	0	0	A	17221547	A	A	17221547	2	1	70	1	0	0	0	0	0	0	0	1	17531	1020	36	4		4	XYLT1	16	17221547	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1379593	17221547	73133206	317	14471											
CDH8	1006	broad.mit.edu	37	chr16	61935158	61935158	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcattgtcattgatgtcttGaactttaataataaattcag	13	17	6	5	0	3	2	2	2	1	0	3	2	3	2	0	0	2	1	0	0	5	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:61935158G>A	uc002eog.1	-	3	724	c.472C>T	c.(472-474)CAA>TAA	p.Q158*		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	158	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTGATGTCTTGAACTTTAATA	0.433													19	62					0	0	0	0	A	61935158	A	A	61935158	4	1	70	1	0	0	0	0	0	1	0	0	3131	1299	45	2	1967	2	CDH8	16	61935158	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	44713611	61935158	28419595	318	14472											
HYDIN	54768	broad.mit.edu	37	chr16	71212846	71212846	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcactttgtcattgttcctCaaaatcagtggaacttcata	11	15	5	10	0	5	0	5	0	0	0	6	1	6	1	1	1	1	1	1	1	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:71212846C>T	uc002ezr.2	-	4	494	c.366G>A	c.(364-366)TTG>TTA	p.L122L	HYDIN_uc010cfz.1_5'UTR|HYDIN_uc002ezv.2_Silent_p.L122L|HYDIN_uc010vmc.1_Silent_p.L139L|HYDIN_uc010vmd.1_Silent_p.L149L|HYDIN_uc002ezw.3_Silent_p.L139L	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	122										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CATTGTTCCTCAAAATCAGTG	0.403													29	89					0	0	0	0	T	71212846	T	T	71212846	2	4	70	1	0	0	0	0	0	0	0	1	7506	825	29	2		2	HYDIN	16	71212846	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	9277688	71212846	19141907	319	14473											
TAT	6898	broad.mit.edu	37	chr16	71609874	71609874	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgagtccagggcatctttCattgcctgggtaacttcagg	7	11	11	12	1	3	0	2	0	1	0	4	1	4	0	3	3	2	2	3	3	1	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:71609874C>G	uc002fap.2	-	3	390	c.291G>C	c.(289-291)ATG>ATC	p.M97I	TAT_uc002faq.2_Missense_Mutation_p.M97I|TAT_uc002far.2_3'UTR	NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	97					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	GGGCATCTTTCATTGCCTGGG	0.488													20	87					0	0	0	0	G	71609874	G	G	71609874	3	3	70	1	0	0	0	0	1	0	0	0	15656	826	29	2	1113	2	TAT	16	71609874	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	397028	71609874	18744879	320	14474											
GLG1	2734	broad.mit.edu	37	chr16	74527006	74527006	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actttataatcctgggcaatCagcttttggcgggttgtaag	9	14	11	7	1	1	0	1	0	0	0	2	0	2	0	1	3	1	4	1	3	4	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:74527006C>G	uc002fcy.3	-	7	1133	c.1083G>C	c.(1081-1083)CTG>CTC	p.L361L	GLG1_uc002fcx.2_Silent_p.L361L|GLG1_uc002fcw.3_Silent_p.L350L|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	361	Cys-rich GLG1 5.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						CCTGGGCAATCAGCTTTTGGC	0.453													22	62					0	0	0	0	G	74527006	G	G	74527006	2	3	70	1	0	0	0	0	0	0	0	1	6473	813	29	2		2	GLG1	16	74527006	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2917132	74527006	15827747	321	14475											
MBTPS1	8720	broad.mit.edu	37	chr16	84089658	84089658	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggggacaagggcctcaCttgagggcgattcgatcgaa	10	7	14	10	3	1	1	1	1	0	0	4	5	2	2	2	4	0	0	2	4	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:84089658C>T	uc002fhi.2	-	22	3416	c.2914G>A	c.(2914-2916)GTG>ATG	p.V972M	MBTPS1_uc002fhh.2_Missense_Mutation_p.V476M	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	972	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						AAGGGCCTCACTTGAGGGCGA	0.498													40	32					0	0	0	0	T	84089658	T	T	84089658	3	4	70	1	0	0	0	0	1	0	0	0	9414	565	20	4	252	4	MBTPS1	16	84089658	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	9562652	84089658	6265095	322	14476											
MYBBP1A	10514	broad.mit.edu	37	chr17	4455427	4455427	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcgtcgcccgcacctggctgGccagaactgcatcttcagca	7	7	11	16	3	2	1	1	0	1	1	3	1	2	1	3	2	3	4	3	2	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:4455427G>A	uc002fyb.3	-	7	960	c.898C>T	c.(898-900)CCA>TCA	p.P300S	MYBBP1A_uc002fxz.3_Missense_Mutation_p.P300S	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	300	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						CACCTGGCTGGCCAGAACTGC	0.627													4	69					0	0	0	0	A	4455427	A	A	4455427	3	1	70	1	0	0	0	0	1	0	0	0	10061	1203	42	4	3208	4	MYBBP1A	17	4455427	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08		4455427	76739783	323	14477											
SLC13A5	284111	broad.mit.edu	37	chr17	6606428	6606428	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtcttcctgctgccccaGagtggggccttcaaaaatca	8	11	10	12	0	3	1	2	0	1	1	4	1	4	1	4	3	2	1	4	3	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:6606428G>A	uc002gdj.2	-	5	665	c.577C>T	c.(577-579)CTG>TTG	p.L193L	SLC13A5_uc010vtf.1_Silent_p.L193L|SLC13A5_uc010clq.2_Silent_p.L150L|SLC13A5_uc002gdk.2_Silent_p.L176L|SLC13A5_uc002gdl.1_Silent_p.L175L	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	193						integral to membrane	citrate transmembrane transporter activity				0						TGCTGCCCCAGAGTGGGGCCT	0.632													25	77					0	0	0	0	A	6606428	A	A	6606428	2	1	70	1	0	0	0	0	0	0	0	1	14460	933	33	2		2	SLC13A5	17	6606428	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2151001	6606428	74588782	324	14478											
TP53	7157	broad.mit.edu	37	chr17	7577106	7577106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtgcgccggtctctcccagGacaggcacaaacacgcacct	9	6	10	16	3	1	0	0	0	1	0	3	1	2	1	3	3	2	2	3	3	1	0	rs17849781		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:7577106G>A	uc002gim.2	-	8	1026	c.832C>T	c.(832-834)CCT>TCT	p.P278S	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.P278S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P146S|TP53_uc010cng.1_Missense_Mutation_p.P146S|TP53_uc002gii.1_Missense_Mutation_p.P146S|TP53_uc010cnh.1_Missense_Mutation_p.P278S|TP53_uc010cni.1_Missense_Mutation_p.P278S|TP53_uc002gij.2_Missense_Mutation_p.P278S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	278	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P278L(52)|p.P278S(48)|p.P278R(26)|p.P278T(21)|p.P278A(18)|p.P278H(11)|p.0?(7)|p.P278fs*67(5)|p.P278F(3)|p.P278fs*28(2)|p.?(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.P278P(1)|p.C277_P278insXXXXXXX(1)|p.F270_D281del12(1)|p.P278_G279insXXXXX(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTCTCCCAGGACAGGCACAA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	32					0	0	0	0	A	7577106	A	A	7577106	3	1	70	1	0	0	0	0	1	0	0	0	16448	1174	41	2	454	2	TP53	17	7577106	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	970678	7577106	73618104	325	14479											
TP53	7157	broad.mit.edu	37	chr17	7578234	7578235	+	Frame_Shift_Ins	INS	-	T	T																															aagtgtttctgtcatccaaaINStactccacacgcaaatttcc																										TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:7578234_7578235insT	uc002gim.2	-	6	808_809	c.614_615insA	c.(613-615)TATfs	p.Y205fs	TP53_uc002gig.1_Frame_Shift_Ins_p.Y205fs|TP53_uc002gih.2_Frame_Shift_Ins_p.Y205fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.Y73fs|TP53_uc010cng.1_Frame_Shift_Ins_p.Y73fs|TP53_uc002gii.1_Frame_Shift_Ins_p.Y73fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.Y205fs|TP53_uc010cni.1_Frame_Shift_Ins_p.Y205fs|TP53_uc002gij.2_Frame_Shift_Ins_p.Y205fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Ins_p.Y112fs|TP53_uc002gio.2_Frame_Shift_Ins_p.Y73fs|TP53_uc010vug.1_Frame_Shift_Ins_p.Y166fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	205	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> C (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205C(55)|p.Y205D(13)|p.Y205S(11)|p.Y205F(8)|p.0?(7)|p.Y205H(5)|p.Y205*(4)|p.Y205N(2)|p.K164_P219del(1)|p.Y205fs*43(1)|p.Y205fs*42(1)|p.Y112C(1)|p.E204fs*39(1)|p.Y73C(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGTCATCCAAATACTCCACACG	0.54		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								T	7578235	T	T	7578234	7	5	70	1	0	1	1	0	0	0	0	0	16448	108	4	0	679	0	TP53	17	7578234	Frame_Shift_Ins	INS	-	TCGA-CN-6011-01A-11D-1683-08	1128	7578234	73616976	326	14480											
GUCY2D	3000	broad.mit.edu	37	chr17	7907263	7907263	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctgggcctgaccgatggctCcctggtcttcctgcccttcg	2	11	12	16	2	1	1	0	1	1	0	4	2	3	1	5	3	1	2	5	3	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:7907263C>T	uc002gjt.2	+	3	889	c.815C>T	c.(814-816)TCC>TTC	p.S272F		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	272	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				ACCGATGGCTCCCTGGTCTTC	0.672													29	96					0	0	0	0	T	7907263	T	T	7907263	3	4	70	1	0	0	0	0	1	0	0	0	6936	855	30	2	821	2	GUCY2D	17	7907263	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	329029	7907263	73287947	327	14481											
KRT34	3885	broad.mit.edu	37	chr17	39538614	39538614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	taattgtgggtgggggcttgGcatacagcatagtttccttt	7	15	13	6	0	0	0	0	0	0	0	1	0	1	0	1	4	2	4	1	4	3	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:39538614G>A	uc002hwm.2	-	1	23	c.11C>T	c.(10-12)GCC>GTC	p.A4V		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	4	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TGGGGGCTTGGCATACAGCAT	0.433													16	15					0	0	0	0	A	39538614	A	A	39538614	3	1	70	1	0	0	0	0	1	0	0	0	8510	1203	42	4	1327	4	KRT34	17	39538614	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	31631351	39538614	41656596	328	14482											
WNT3	7473	broad.mit.edu	37	chr17	44851102	44851102	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagttccagcggcggcccCggaactggtgctggcactcc	5	7	14	15	3	0	0	0	0	0	0	2	1	2	1	4	5	4	4	4	5	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:44851102C>T	uc002ikv.2	-	2	373	c.254G>A	c.(253-255)CGG>CAG	p.R85Q		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	85					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GCGGCGGCCCCGGAACTGGTG	0.647													34	16					0	0	0	0	T	44851102	T	T	44851102	3	4	70	1	0	0	0	0	1	0	0	0	17456	652	23	1	825	1	WNT3	17	44851102	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	5312488	44851102	36344108	329	14483											
RAD51C	5889	broad.mit.edu	37	chr17	56770070	56770070	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtttcccgctgtctccagcGgtgcgggtgaagctggtgtc	4	11	15	11	3	1	1	0	1	1	0	4	1	2	1	2	3	3	3	2	3	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:56770070G>A	uc002iwu.2	+	1	108	c.66G>A	c.(64-66)GCG>GCA	p.A22A	TEX14_uc002iwr.1_5'Flank|TEX14_uc002iws.1_5'Flank|TEX14_uc010dcz.1_5'Flank|TEX14_uc010dda.1_5'Flank|TEX14_uc010wnz.1_5'Flank|RAD51C_uc002iwt.1_Silent_p.A22A|RAD51C_uc010woa.1_Silent_p.A22A|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA|RAD51C_uc010wob.1_Intron	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	22					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGTCTCCAGCGGTGCGGGTGA	0.587								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				37	16					0	0	0	0	A	56770070	A	A	56770070	2	1	70	1	0	0	0	0	0	0	0	1	13053	1103	39	1		1	RAD51C	17	56770070	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	11918968	56770070	24425140	330	14484											
BRIP1	83990	broad.mit.edu	37	chr17	59761063	59761063	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caaaatctctatttgaagtgGactgtttatcttcttcactt	10	18	5	8	0	4	1	1	1	3	0	5	2	4	2	0	1	0	1	0	1	5	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:59761063G>A	uc002izk.1	-	20	3485	c.3344C>T	c.(3343-3345)TCC>TTC	p.S1115F		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	1115					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						ATTTGAAGTGGACTGTTTATC	0.353			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				44	17					0	0	0	0	A	59761063	A	A	59761063	3	1	70	1	0	0	0	0	1	0	0	0	1519	1174	41	2	409	2	BRIP1	17	59761063	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2990993	59761063	21434147	331	14485											
RAB31	11031	broad.mit.edu	37	chr18	9708423	9708423	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgatggcgatacgggagctCaaagtgtgccttctcggggt	8	10	15	8	3	2	1	1	1	1	0	3	3	2	2	1	4	3	1	1	4	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:9708423C>G	uc002kog.2	+	1	196	c.21C>G	c.(19-21)CTC>CTG	p.L7L		NM_006868	NP_006859	Q13636	RAB31_HUMAN	RAB31, member RAS oncogene family	6					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						TACGGGAGCTCAAAGTGTGCC	0.592													4	18					0	0	0	0	G	9708423	G	G	9708423	2	3	70	1	0	0	0	0	0	0	0	1	12985	813	29	2		2	RAB31	18	9708423	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08		9708423	68368825	332	14486											
POTEC	388468	broad.mit.edu	37	chr18	14513720	14513720	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtttattagtcagaatctCatcttgtgatattccagtgt	9	19	7	6	0	3	2	2	1	2	1	5	2	4	2	1	0	0	1	1	0	4	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:14513720C>T	uc010dln.2	-	10	1928	c.1474G>A	c.(1474-1476)GAG>AAG	p.E492K	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	492	Potential.									skin(3)	3						GTCAGAATCTCATCTTGTGAT	0.313													4	36					0	0	0	0	T	14513720	T	T	14513720	3	4	70	1	0	0	0	0	1	0	0	0	12317	835	29	2	162	2	POTEC	18	14513720	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	4805297	14513720	63563528	333	14487											
ANKRD30B	374860	broad.mit.edu	37	chr18	14851748	14851748	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtatagagagcagcttaaaGttctgacggcagagaacacg	15	7	12	7	2	1	3	0	1	1	2	1	5	1	3	0	1	3	5	0	1	5	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:14851748G>C	uc010dlo.2	+	36	3628	c.3448G>C	c.(3448-3450)GTT>CTT	p.V1150L	ANKRD30B_uc010xal.1_Missense_Mutation_p.V292L	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1235	Potential.									ovary(1)|skin(1)	2						GCAGCTTAAAGTTCTGACGGC	0.373													12	10					0	0	0	0	C	14851748	C	C	14851748	3	2	70	1	0	0	0	0	1	0	0	0	659	1029	36	4	3590	4	ANKRD30B	18	14851748	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	338028	14851748	63225500	334	14488											
CDH2	1000	broad.mit.edu	37	chr18	25568547	25568547	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttcacatttggtgattctCggtccaaaacagcaattgta	11	15	7	8	1	2	1	1	1	1	0	4	1	3	1	1	2	2	2	1	2	4	6			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:25568547C>T	uc002kwg.2	-	11	2141	c.1682G>A	c.(1681-1683)CGA>CAA	p.R561Q	CDH2_uc010xbn.1_Missense_Mutation_p.R530Q	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	561	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TGGTGATTCTCGGTCCAAAAC	0.333													12	20					0	0	0	0	T	25568547	T	T	25568547	3	4	70	1	0	0	0	0	1	0	0	0	3120	884	31	1	1062	1	CDH2	18	25568547	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	10716799	25568547	52508701	335	14489											
ASXL3	80816	broad.mit.edu	37	chr18	31324115	31324115	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcctcccaagttaagtgctGaaagcttggacaaaaattca	14	10	8	9	0	1	1	1	1	0	0	3	2	3	2	2	1	2	3	2	1	5	3	rs144287211	by1000genomes	TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:31324115G>C	uc010dmg.1	+	12	4358	c.4303G>C	c.(4303-4305)GAA>CAA	p.E1435Q	ASXL3_uc002kxq.2_Missense_Mutation_p.E1142Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GTTAAGTGCTGAAAGCTTGGA	0.488											OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	176					0	0	0	0	C	31324115	C	C	31324115	3	2	70	1	0	0	0	0	1	0	0	0	1070	1291	45	2	4349	2	ASXL3	18	31324115	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	5755568	31324115	46753133	336	14490											
MBP	4155	broad.mit.edu	37	chr18	74729142	74729142	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggcatcctgccaggcattCttcgggtccgctgtgcgctt	3	12	13	13	3	1	0	0	0	1	0	4	0	3	0	3	3	2	4	3	3	0	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:74729142C>G	uc010xfd.1	-	4	486	c.222G>C	c.(220-222)AAG>AAC	p.K74N	MBP_uc002lml.2_5'Flank|MBP_uc002lmn.2_5'Flank|MBP_uc002lmp.2_5'Flank|MBP_uc010xfe.1_5'UTR|MBP_uc002lmr.2_Missense_Mutation_p.K74N	NM_001025101	NP_001020272	P02686	MBP_HUMAN	Golli-mbp isoform 1	74					central nervous system development|immune response|synaptic transmission	plasma membrane	structural constituent of myelin sheath			haematopoietic_and_lymphoid_tissue(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.79e-06)|BRCA - Breast invasive adenocarcinoma(31;0.113)|READ - Rectum adenocarcinoma(1;0.188)		GCCAGGCATTCTTCGGGTCCG	0.607													20	9					0	0	0	0	G	74729142	G	G	74729142	3	3	70	1	0	0	0	0	1	0	0	0	9412	912	32	2	816	2	MBP	18	74729142	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	43405027	74729142	3348106	337	14491											
BSG	682	broad.mit.edu	37	chr19	571571	571571	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagcagtcggacgcgtctccCcaagaaaggtaaccgccagc	12	4	11	14	4	1	1	0	0	1	1	3	2	1	2	4	2	3	2	4	2	4	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:571571C>T	uc002loz.2	+						BSG_uc002loy.2_Silent_p.P8P|BSG_uc002lpa.2_5'Flank|BSG_uc002lpb.2_5'Flank|BSG_uc010drr.2_5'Flank	NM_001728	NP_001719	P35613	BASI_HUMAN	basigin isoform 1 precursor						blood coagulation|cell surface receptor linked signaling pathway|leukocyte migration|pyruvate metabolic process	Golgi membrane|integral to membrane|melanosome	lactate transmembrane transporter activity|mannose binding|protein binding				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		acgcgtctccccaagaaaggt	0.075													9	26					0	0	0	0	T	571571	T	T	571571	1	4	70	0	1	0	0	0	0	0	0	0	1534	610	22	4		4	BSG	19	571571	5'Flank	SNP	C	TCGA-CN-6011-01A-11D-1683-08		571571	58557412	338	14492											
HMHA1	23526	broad.mit.edu	37	chr19	1085820	1085820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcagccacagcggcagtgagGagcagctggaggccacagcc	10	2	16	13	1	0	1	0	1	0	0	0	3	0	3	3	4	5	4	3	4	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:1085820G>A	uc002lqz.1	+	23	3457	c.3226G>A	c.(3226-3228)GAG>AAG	p.E1076K	HMHA1_uc010xgd.1_Missense_Mutation_p.E1092K|HMHA1_uc010xge.1_Missense_Mutation_p.E944K|HMHA1_uc002lra.1_Missense_Mutation_p.E916K|HMHA1_uc002lrb.1_Missense_Mutation_p.E959K|HMHA1_uc002lrc.1_Missense_Mutation_p.E711K|HMHA1_uc002lrd.1_Missense_Mutation_p.E152K|HMHA1_uc010dsd.1_Missense_Mutation_p.E182K	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	1076					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCAGTGAGGAGCAGCTGGA	0.672													12	18					0	0	0	0	A	1085820	A	A	1085820	3	1	70	1	0	0	0	0	1	0	0	0	7279	1175	41	2	3316	2	HMHA1	19	1085820	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	514249	1085820	58043163	339	14493											
MEX3D	399664	broad.mit.edu	37	chr19	1556757	1556757	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagacccccggccttgctgCgcgtggcgcggatgatggag	5	6	17	13	5	0	2	0	1	0	1	0	4	0	4	3	4	2	2	3	4	0	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:1556757C>T	uc010dsn.2	-	2	761	c.761G>A	c.(760-762)CGC>CAC	p.R254H		NM_203304	NP_976049	Q86XN8	MEX3D_HUMAN	ring finger and KH domain containing 1	254					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCTTGCTGCGCGTGGCGCG	0.706													16	41					0	0	0	0	T	1556757	T	T	1556757	3	4	70	1	0	0	0	0	1	0	0	0	9565	768	27	1	1261	1	MEX3D	19	1556757	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	470937	1556757	57572226	340	14494											
TIMM13	26517	broad.mit.edu	37	chr19	2427036	2427036	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tagcggtccatgcacatggcGatgcacttctgcgggagcgg	7	8	15	11	4	1	0	0	0	1	0	2	2	2	1	1	4	5	2	1	4	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:2427036G>C	uc002lvx.1	-	3	542	c.198C>G	c.(196-198)ATC>ATG	p.I66M		NM_012458	NP_036590	Q9Y5L4	TIM13_HUMAN	translocase of inner mitochondrial membrane 13	66	Twin CX3C motif.				protein import into mitochondrial inner membrane|sensory perception of sound|transmembrane transport	mitochondrial inner membrane presequence translocase complex|mitochondrial intermembrane space protein transporter complex	protein binding|zinc ion binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCACATGGCGATGCACTTCT	0.706													5	7					0	0	0	0	C	2427036	C	C	2427036	3	2	70	1	0	0	0	0	1	0	0	0	15972	1048	37	3	93	3	TIMM13	19	2427036	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	870279	2427036	56701947	341	14495											
ZNF555	148254	broad.mit.edu	37	chr19	2853240	2853240	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaaaggactcatggtggaGagaaaccctatgaatgcaac	16	7	11	7	0	1	3	1	2	0	1	1	6	1	5	1	3	3	1	1	3	5	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:2853240G>C	uc002lwo.2	+	4	1266	c.1177G>C	c.(1177-1179)GAG>CAG	p.E393Q	ZNF555_uc002lwn.3_Missense_Mutation_p.E392Q	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCATGGTGGAGAGAAACCCTA	0.493													11	23					0	0	0	0	C	2853240	C	C	2853240	3	2	70	1	0	0	0	0	1	0	0	0	18053	943	33	2	1191	2	ZNF555	19	2853240	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	426204	2853240	56275743	342	14496											
NCLN	56926	broad.mit.edu	37	chr19	3192541	3192541	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagccgccgctgcgtgctCatgcggctactggacttctc	4	10	12	15	4	2	1	1	1	1	0	3	2	2	2	2	2	5	3	2	2	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:3192541C>T	uc002lxi.2	+	2	412	c.258C>T	c.(256-258)CTC>CTT	p.L86L	NCLN_uc002lxh.1_RNA	NM_020170	NP_064555	Q969V3	NCLN_HUMAN	nicalin precursor	86	Lumenal (Potential).				proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGCGTGCTCATGCGGCTAC	0.697													6	18					0	0	0	0	T	3192541	T	T	3192541	2	4	70	1	0	0	0	0	0	0	0	1	10281	813	29	2		2	NCLN	19	3192541	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	339301	3192541	55936442	343	14497											
MUC16	94025	broad.mit.edu	37	chr19	9084208	9084208	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaaggcagtggctggttcaAtagttgatgctagaagtgag	11	11	15	4	0	1	4	1	3	0	1	1	4	1	4	0	3	1	5	0	3	5	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:9084208A>G	uc002mkp.2	-	1	7811	c.7607T>C	c.(7606-7608)ATT>ACT	p.I2536T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2536	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCTGGTTCAATAGTTGATGC	0.507													12	29					0	0	0	0	G	9084208	G	G	9084208	3	3	70	1	0	0	0	0	1	0	0	0	10026	101	4	5	36252	5	MUC16	19	9084208	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08	5891667	9084208	50044775	344	14498											
ZNF560	147741	broad.mit.edu	37	chr19	9578107	9578107	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagtgtgagttctcaaatGagcaaaaagagatgagaaag	18	7	11	5	0	1	4	1	3	1	2	2	6	1	4	1	0	1	2	1	0	4	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:9578107G>C	uc002mlp.1	-	10	1726	c.1516C>G	c.(1516-1518)CAT>GAT	p.H506D	ZNF560_uc010dwr.1_Missense_Mutation_p.H400D	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	506	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						GTTCTCAAATGAGCAAAAAGA	0.413													13	93					0	0	0	0	C	9578107	C	C	9578107	3	2	70	1	0	0	0	0	1	0	0	0	18058	1290	45	2	860	2	ZNF560	19	9578107	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	493899	9578107	49550876	345	14499											
ZNF433	163059	broad.mit.edu	37	chr19	12126809	12126809	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaaggaatgggaagagctGaaggctttcccacactgttt	12	10	12	7	0	0	3	0	2	0	1	1	5	1	5	1	3	1	3	1	3	4	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:12126809G>C	uc002msy.1	-	4	1044	c.873C>G	c.(871-873)TTC>TTG	p.F291L	uc002msx.1_Intron|ZNF433_uc002msz.1_Missense_Mutation_p.F256L	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	291	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGAAGAGCTGAAGGCTTTCC	0.433													13	37					0	0	0	0	C	12126809	C	C	12126809	3	2	70	1	0	0	0	0	1	0	0	0	17974	1281	45	2	1152	2	ZNF433	19	12126809	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2548702	12126809	47002174	346	14500											
OR7A10	390892	broad.mit.edu	37	chr19	14952228	14952228	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctttgtaacatggaattCagaacactcatgatccagga	15	10	8	8	0	2	2	2	1	0	1	3	4	3	4	1	2	3	2	1	2	4	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:14952228C>G	uc002mzx.1	-	1	462	c.462G>C	c.(460-462)CTG>CTC	p.L154L		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					ACATGGAATTCAGAACACTCA	0.458													4	64					0	0	0	0	G	14952228	G	G	14952228	2	3	70	1	0	0	0	0	0	0	0	1	11268	813	29	2		2	OR7A10	19	14952228	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2825419	14952228	44176755	347	14501											
NOTCH3	4854	broad.mit.edu	37	chr19	15291928	15291928	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggacggcacaggcagctGaacgagttcacgccgtccac	9	4	13	15	5	1	1	1	1	0	0	2	3	2	2	3	3	2	4	3	3	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:15291928G>T	uc002nan.2	-	18	2914	c.2838C>A	c.(2836-2838)TTC>TTA	p.F946L	NOTCH3_uc002nao.1_Missense_Mutation_p.F894L	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	946	Extracellular (Potential).|EGF-like 24.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			acaggcagctgaacgagttca	0.274													4	14					0.00024832	0.000255548	1	0	T	15291928	T	T	15291928	3	4	70	1	0	0	0	0	1	0	0	0	10604	1281	45	2	4191	2	NOTCH3	19	15291928	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	339700	15291928	43837055	348	14502											
CPAMD8	27151	broad.mit.edu	37	chr19	17111256	17111256	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaggacagggcgtcccacctCgtggctgtagtaccctacac	8	7	12	14	2	0	0	0	0	0	0	2	2	1	1	3	3	2	3	3	3	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:17111256C>G	uc002nfb.2	-	10	1008	c.976G>C	c.(976-978)GAG>CAG	p.E326Q		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	279						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CGTCCCACCTCGTGGCTGTAG	0.517													6	19					0	0	0	0	G	17111256	G	G	17111256	3	3	70	1	0	0	0	0	1	0	0	0	3810	893	31	3	4954	3	CPAMD8	19	17111256	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	1819328	17111256	42017727	349	14503											
ZNF100	163227	broad.mit.edu	37	chr19	21948580	21948580	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaggacacattccatacctCgggtcatcctacgggagaaa	13	7	10	11	2	1	2	1	0	0	2	4	4	3	3	3	3	2	0	3	3	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:21948580C>T	uc002nqi.2	-	2	211	c.12G>A	c.(10-12)CCG>CCA	p.P4P		NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCCATACCTCGGGTCATCCT	0.483													18	46					0	0	0	0	T	21948580	T	T	21948580	2	4	70	1	0	0	0	0	0	0	0	1	17780	871	31	1		1	ZNF100	19	21948580	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	4837324	21948580	37180403	350	14504											
ZNF208	7757	broad.mit.edu	37	chr19	22156005	22156005	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttttgccacattcttcacAtttgtagggtttctcaccag	7	16	8	10	0	3	0	2	0	2	0	4	0	3	0	2	2	1	3	2	2	1	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:22156005A>T	uc002nqp.2	-	5	1680	c.1531T>A	c.(1531-1533)TGT>AGT	p.C511S	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CATTCTTCACATTTGTAGGGT	0.373													27	23					0	0	0	0	T	22156005	T	T	22156005	3	4	70	1	0	0	0	0	1	0	0	0	17833	217	8	5	2015	5	ZNF208	19	22156005	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08	207425	22156005	36972978	351	14505											
NUDT19	390916	broad.mit.edu	37	chr19	33200187	33200187	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagaagacttgcaaactttGcctctctctctgacttgcac	9	13	7	12	0	2	3	0	2	2	2	4	4	2	3	1	0	4	2	1	0	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:33200187G>A	uc010edf.2	+	2	811	c.811G>A	c.(811-813)GCC>ACC	p.A271T		NM_001105570	NP_001099040	A8MXV4	NUD19_HUMAN	nudix (nucleoside diphosphate linked moiety	271						mitochondrion|peroxisome	hydrolase activity|metal ion binding				0	Esophageal squamous(110;0.137)					TGCAAACTTTGCCTCTCTCTC	0.453													52	175					0	0	0	0	A	33200187	A	A	33200187	3	1	70	1	0	0	0	0	1	0	0	0	10790	1319	46	4	817	4	NUDT19	19	33200187	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	11044182	33200187	25928796	352	14506											
RHPN2	85415	broad.mit.edu	37	chr19	33493179	33493179	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcgatgaggaggatggcaGtgaagtagtgggccagggcc	9	6	20	6	1	0	2	0	2	0	0	1	5	0	4	2	6	0	2	2	6	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:33493179G>C	uc002nuf.2	-	9	1145	c.1079C>G	c.(1078-1080)ACT>AGT	p.T360S	RHPN2_uc010xro.1_Missense_Mutation_p.T209S|RHPN2_uc002nue.2_Missense_Mutation_p.T90S	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	360	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					GAGGATGGCAGTGAAGTAGTG	0.647													20	37					0	0	0	0	C	33493179	C	C	33493179	3	2	70	1	0	0	0	0	1	0	0	0	13416	1029	36	4	1009	4	RHPN2	19	33493179	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	292992	33493179	25635804	353	14507											
MAP4K1	11184	broad.mit.edu	37	chr19	39103307	39103307	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggccagttcgatggccgtGatgcccagggaccagatgtc	7	8	14	12	3	0	2	0	1	0	1	3	4	0	3	4	3	1	1	4	3	0	1	rs56029962		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:39103307G>A	uc002oix.1	-	9	717	c.609C>T	c.(607-609)ATC>ATT	p.I203I	MAP4K1_uc002oiy.1_Silent_p.I203I|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	203	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CGATGGCCGTGATGCCCAGGG	0.627													26	70					0	0	0	0	A	39103307	A	A	39103307	2	1	70	1	0	0	0	0	0	0	0	1	9312	1280	45	2		2	MAP4K1	19	39103307	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	5610128	39103307	20025676	354	14508											
PSG7	5676	broad.mit.edu	37	chr19	43433864	43433864	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctggagatggagggtttggGagtctccactgtgcggaaaa	9	9	17	6	1	1	1	0	0	1	1	2	5	1	4	1	5	1	2	1	5	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:43433864G>T	uc002ovl.3	-	4	541	c.439C>A	c.(439-441)CCC>ACC	p.P147T	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_5'Flank|PSG7_uc002out.1_5'UTR|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.P25T	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	147	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GAGGGTTTGGGAGTCTCCACT	0.512													61	13					1.43675e-24	1.56996e-24	1	0	T	43433864	T	T	43433864	3	4	70	1	0	0	0	0	1	0	0	0	12722	1174	41	2	836	2	PSG7	19	43433864	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	4330557	43433864	15695119	355	14509											
IRGC	56269	broad.mit.edu	37	chr19	44223308	44223308	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatccgagaccactgtgccGagcggctgcgggaggccggc	7	4	17	13	5	0	2	0	0	0	2	1	5	1	3	4	4	3	1	4	4	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:44223308G>A	uc002oxh.2	+	2	745	c.598G>A	c.(598-600)GAG>AAG	p.E200K		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	200						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CCACTGTGCCGAGCGGCTGCG	0.701													14	54					0	0	0	0	A	44223308	A	A	44223308	3	1	70	1	0	0	0	0	1	0	0	0	7877	1059	37	1	600	1	IRGC	19	44223308	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	789444	44223308	14905675	356	14510											
ZFP112	7771	broad.mit.edu	37	chr19	44831903	44831903	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actgaaacccttaccacactGttcacatttatagggtctcc	11	12	5	13	0	2	1	1	1	1	0	3	1	2	1	3	1	2	1	3	1	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:44831903G>A	uc010ejj.2	-	5	2538	c.2425C>T	c.(2425-2427)CAG>TAG	p.Q809*	ZFP112_uc002ozc.3_Nonsense_Mutation_p.Q803*|ZFP112_uc010xwy.1_Nonsense_Mutation_p.Q826*|ZFP112_uc010xwz.1_Nonsense_Mutation_p.Q808*	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	809	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TTACCACACTGTTCACATTTA	0.458													37	100					0	0	0	0	A	44831903	A	A	44831903	4	1	70	1	0	0	0	0	0	1	0	0	17705	1386	48	4	320	4	ZFP112	19	44831903	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	608595	44831903	14297080	357	14511											
CKM	1158	broad.mit.edu	37	chr19	45818846	45818846	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgtagttagggtccaggtCgtctccaccctggagagcgg	7	8	14	12	3	1	1	0	0	1	1	4	2	2	1	3	4	1	2	3	4	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:45818846C>A	uc002pbd.2	-	4	432	c.358G>T	c.(358-360)GAC>TAC	p.D120Y		NM_001824	NP_001815	P06732	KCRM_HUMAN	muscle creatine kinase	120					creatine metabolic process	cytosol	ATP binding|creatine kinase activity			skin(1)	1		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	GGGTCCAGGTCGTCTCCACCC	0.677													10	25					2.17888e-05	2.25637e-05	1	0	A	45818846	A	A	45818846	3	1	70	1	0	0	0	0	1	0	0	0	3463	884	31	3	807	3	CKM	19	45818846	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	986943	45818846	13310137	358	14512											
DACT3	147906	broad.mit.edu	37	chr19	47151925	47151925	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacgaggccaccgctgccGtctgagtcgctggaggcaga	8	5	14	14	4	1	2	0	1	1	1	2	4	1	3	3	3	1	3	3	3	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:47151925G>A	uc010ekq.2	-	4	1778	c.1704C>T	c.(1702-1704)GAC>GAT	p.D568D		NM_145056	NP_659493	Q96B18	DACT3_HUMAN	thymus expressed gene 3-like	568											0		Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000173)|all cancers(93;0.000464)|Epithelial(262;0.02)|GBM - Glioblastoma multiforme(486;0.0325)		CACCGCTGCCGTCTGAGTCGC	0.736													17	32					0	0	0	0	A	47151925	A	A	47151925	2	1	70	1	0	0	0	0	0	0	0	1	4240	1136	40	1		1	DACT3	19	47151925	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1333079	47151925	11977058	359	14513											
DBP	1628	broad.mit.edu	37	chr19	49140149	49140149	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcttgctggtcccctgcaGaaggctccgcaacccaagca	8	6	12	15	1	0	1	0	0	0	1	2	1	2	1	4	3	4	6	4	3	3	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:49140149G>A	uc002pjx.3	-	1	491	c.103C>T	c.(103-105)CTG>TTG	p.L35L	SEC1_uc010xzv.1_5'Flank|SEC1_uc002pka.2_5'Flank|SEC1_uc010xzw.1_5'Flank|SEC1_uc010ema.2_5'Flank|DBP_uc002pjy.2_Silent_p.L35L|DBP_uc010elz.1_Silent_p.L35L	NM_001352	NP_001343	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box)	35					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		GTCCCCTGCAGAAGGCTCCGC	0.701													3	10					0	0	0	0	A	49140149	A	A	49140149	2	1	70	1	0	0	0	0	0	0	0	1	4273	933	33	2		2	DBP	19	49140149	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1988224	49140149	9988834	360	14514											
GYS1	2997	broad.mit.edu	37	chr19	49484831	49484831	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttgagggtttccacgttGaaattgttggtccgcgctgg	5	14	13	9	3	0	2	0	2	0	0	2	2	2	2	3	3	0	4	3	3	1	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:49484831G>T	uc002plp.2	-	8	1366	c.1125C>A	c.(1123-1125)TTC>TTA	p.F375L	GYS1_uc010xzy.1_Missense_Mutation_p.F8L|GYS1_uc010emm.2_Missense_Mutation_p.F311L|GYS1_uc010xzz.1_Missense_Mutation_p.F295L|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	375					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TTTCCACGTTGAAATTGTTGG	0.587													4	33					0.00198382	0.00202472	1	0	T	49484831	T	T	49484831	3	4	70	1	0	0	0	0	1	0	0	0	6951	1281	45	2	1124	2	GYS1	19	49484831	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	344682	49484831	9644152	361	14515											
SLC17A7	57030	broad.mit.edu	37	chr19	49935905	49935905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcagcgcggacaccaggcCtacctgcgggaacaggtgta	9	4	16	12	3	0	0	0	0	0	0	0	2	0	2	3	5	4	2	3	5	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:49935905C>T	uc002pnp.2	-	9	1193	c.1021G>A	c.(1021-1023)GGC>AGC	p.G341S	SLC17A7_uc002pno.2_Missense_Mutation_p.G40S	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	341	Extracellular (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GACACCAGGCCTACCTGCGGG	0.692													18	13					0	0	0	0	T	49935905	T	T	49935905	3	4	70	1	0	0	0	0	1	0	0	0	14487	681	24	4	677	4	SLC17A7	19	49935905	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	451074	49935905	9193078	362	14516											
TSKS	60385	broad.mit.edu	37	chr19	50243129	50243129	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctcaagtggcaggttgctGagatgatcgtggagggagca	9	8	16	8	1	1	2	1	2	0	1	2	5	1	4	1	4	2	4	1	4	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:50243129G>A	uc002ppm.2	-	11	1694	c.1683C>T	c.(1681-1683)CTC>CTT	p.L561L		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	561							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GCAGGTTGCTGAGATGATCGT	0.587													31	75					0	0	0	0	A	50243129	A	A	50243129	2	1	70	1	0	0	0	0	0	0	0	1	16693	1277	45	2		2	TSKS	19	50243129	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	307224	50243129	8885854	363	14517											
SIGLEC6	946	broad.mit.edu	37	chr19	52034048	52034048	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggggtgattgtgagcaccGaggactgggtggtcctgggg	5	9	21	6	1	0	2	0	2	0	0	1	4	1	3	2	7	1	1	2	7	0	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:52034048G>A	uc002pwy.2	-	3	755	c.593C>T	c.(592-594)TCG>TTG	p.S198L	SIGLEC6_uc002pwz.2_Missense_Mutation_p.S198L|SIGLEC6_uc002pxa.2_Missense_Mutation_p.S198L|SIGLEC6_uc010ydb.1_Missense_Mutation_p.S151L|SIGLEC6_uc010ydc.1_Missense_Mutation_p.S187L|SIGLEC6_uc010eoz.1_Missense_Mutation_p.S176L|SIGLEC6_uc010epb.1_Missense_Mutation_p.S151L|SIGLEC6_uc010epa.1_Missense_Mutation_p.S187L	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	198	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TGTGAGCACCGAGGACTGGGT	0.652													19	66					0	0	0	0	A	52034048	A	A	52034048	3	1	70	1	0	0	0	0	1	0	0	0	14377	1059	37	1	825	1	SIGLEC6	19	52034048	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1790919	52034048	7094935	364	14518											
HAS1	3036	broad.mit.edu	37	chr19	52217097	52217097	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgccttggccagtgccacGccctgcacgcacagcagcac	7	4	11	19	3	0	0	0	0	0	0	0	0	0	0	5	1	4	4	5	1	0	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:52217097G>A	uc002pxo.1	-	5	1355	c.1320C>T	c.(1318-1320)GGC>GGT	p.G440G	HAS1_uc010epc.1_Silent_p.G40G|HAS1_uc010epd.1_3'UTR|HAS1_uc002pxn.1_Silent_p.G447G|HAS1_uc002pxp.1_Silent_p.G439G	NM_001523	NP_001514	Q92839	HAS1_HUMAN	hyaluronan synthase 1	440	Helical; Name=4; (Potential).				cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			ovary(1)|pancreas(1)	2		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CCAGTGCCACGCCCTGCACGC	0.697													7	13					0	0	0	0	A	52217097	A	A	52217097	2	1	70	1	0	0	0	0	0	0	0	1	7000	1074	38	1		1	HAS1	19	52217097	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	183049	52217097	6911886	365	14519											
PRKCG	5582	broad.mit.edu	37	chr19	54409999	54409999	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactttgacaagttcttcacGcgggcggcgccagcgctgac	8	8	12	13	5	2	2	1	2	1	0	2	2	2	2	1	2	2	2	1	2	2	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:54409999G>A	uc002qcq.1	+	18	2226	c.1944G>A	c.(1942-1944)ACG>ACA	p.T648T	PRKCG_uc010yeg.1_Silent_p.T648T|PRKCG_uc010yeh.1_Silent_p.T499T	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	648	AGC-kinase C-terminal.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		AGTTCTTCACGCGGGCGGCGC	0.647											OREG0025667	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	90					0	0	0	0	A	54409999	A	A	54409999	2	1	70	1	0	0	0	0	0	0	0	1	12574	1074	38	1		1	PRKCG	19	54409999	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2192902	54409999	4718984	366	14520											
NDUFA3	4696	broad.mit.edu	37	chr19	54606193	54606193	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcggagacaaagatggctGcgagtaagtgcaggttccgg	10	6	16	9	4	0	2	0	0	0	2	1	4	1	2	2	4	2	4	2	4	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:54606193G>A	uc002qde.2	+	1	34	c.7G>A	c.(7-9)GCG>ACG	p.A3T	OSCAR_uc002qcy.2_5'Flank|OSCAR_uc002qcz.2_5'Flank|OSCAR_uc002qda.2_5'Flank|OSCAR_uc002qdb.2_5'Flank|OSCAR_uc010erc.2_5'Flank|OSCAR_uc002qdc.2_5'Flank|OSCAR_uc002qdd.2_5'Flank|NDUFA3_uc002qdf.2_RNA	NM_004542	NP_004533	O95167	NDUA3_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	3					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)	1	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)				NADH(DB00157)	AAAGATGGCTGCGAGTAAGTG	0.692											OREG0003682|OREG0003632	type=REGULATORY REGION|Gene=NDUFA3|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|Gene=BC035023|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	9	11					0	0	0	0	A	54606193	A	A	54606193	3	1	70	1	0	0	0	0	1	0	0	0	10319	1319	46	4	9	4	NDUFA3	19	54606193	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	196194	54606193	4522790	367	14521											
ZNF471	57573	broad.mit.edu	37	chr19	57035959	57035959	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatctggaaaacatagaaGagagtatttataatcacaca	18	10	6	7	0	2	2	1	0	1	2	3	4	3	3	1	1	1	1	1	1	7	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:57035959G>A	uc002qnh.2	+	5	656	c.523G>A	c.(523-525)GAG>AAG	p.E175K		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		AAACATAGAAGAGAGTATTTA	0.284													3	28					0	0	0	0	A	57035959	A	A	57035959	3	1	70	1	0	0	0	0	1	0	0	0	17997	943	33	2	537	2	ZNF471	19	57035959	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2429766	57035959	2093024	368	14522											
ZNF470	388566	broad.mit.edu	37	chr19	57088415	57088415	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaattttcatacagataaGaaaagcttaaaaacacattc	19	13	3	6	0	1	2	1	0	0	2	2	2	1	2	0	0	3	1	0	0	8	8			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:57088415G>C	uc002qnl.3	+	6	1294	c.618G>C	c.(616-618)AAG>AAC	p.K206N	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		ATACAGATAAGAAAAGCTTAA	0.289													23	19					0	0	0	0	C	57088415	C	C	57088415	3	2	70	1	0	0	0	0	1	0	0	0	17996	933	33	2	632	2	ZNF470	19	57088415	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	52456	57088415	2040568	369	14523											
ZNF835	90485	broad.mit.edu	37	chr19	57175000	57175000	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgccagggcacccctgttGacaggtttctcctccctgtg	4	12	10	15	0	2	1	0	1	2	0	4	1	3	1	5	2	1	3	5	2	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:57175000G>T	uc010ygo.1	-	2	1633	c.1633C>A	c.(1633-1635)CAA>AAA	p.Q545K	ZNF835_uc010ygn.1_Missense_Mutation_p.Q523K	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CACCCCTGTTGACAGGTTTCT	0.507													18	63					9.16793e-09	9.67617e-09	1	0	T	57175000	T	T	57175000	3	4	70	1	0	0	0	0	1	0	0	0	18253	1299	45	2	48	2	ZNF835	19	57175000	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	86585	57175000	1953983	370	14524											
CDC25B	994	broad.mit.edu	37	chr20	3782998	3782998	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcctggacagtgaccaccGagagctgattggagattact	10	9	11	11	1	0	4	0	2	0	2	1	7	1	5	4	2	2	1	4	2	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:3782998G>A	uc002wjn.2	+	11	1947	c.1169G>A	c.(1168-1170)CGA>CAA	p.R390Q	CDC25B_uc010zqk.1_Missense_Mutation_p.R326Q|CDC25B_uc010zql.1_Missense_Mutation_p.R312Q|CDC25B_uc010zqm.1_Missense_Mutation_p.R299Q|CDC25B_uc002wjl.2_Missense_Mutation_p.R278Q|CDC25B_uc002wjm.2_Missense_Mutation_p.R278Q|CDC25B_uc002wjo.2_Missense_Mutation_p.R376Q|CDC25B_uc002wjp.2_Missense_Mutation_p.R349Q|CDC25B_uc002wjq.2_Missense_Mutation_p.R190Q|CDC25B_uc010gbc.2_5'Flank	NM_021873	NP_068659	P30305	MPIP2_HUMAN	cell division cycle 25B isoform 1	390					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|ovary(2)	5						AGTGACCACCGAGAGCTGATT	0.567													13	22					0	0	0	0	A	3782998	A	A	3782998	3	1	70	1	0	0	0	0	1	0	0	0	3078	1058	37	1	1211	1	CDC25B	20	3782998	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08		3782998	59242522	371	14525											
FLRT3	23767	broad.mit.edu	37	chr20	14306766	14306766	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagggctgtgaccaagtactCactgcgttcccctgttacaa	9	10	9	13	1	1	1	1	1	0	0	2	1	2	1	3	1	3	4	3	1	4	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:14306766C>G	uc002wov.1	-	3	1854	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.E463Q	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	463	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		ACCAAGTACTCACTGCGTTCC	0.468													16	32					0	0	0	0	G	14306766	G	G	14306766	3	3	70	1	0	0	0	0	1	0	0	0	5972	835	29	2	566	2	FLRT3	20	14306766	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	10523768	14306766	48718754	372	14526											
XKR7	343702	broad.mit.edu	37	chr20	30584930	30584930	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacccgctgacgccatcacGagtccccccaggtccctgcc	6	5	8	22	3	1	1	1	1	0	0	3	2	3	1	8	1	1	1	8	1	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:30584930G>A	uc002wxe.2	+	3	1584	c.1410G>A	c.(1408-1410)ACG>ACA	p.T470T		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	470						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			ACGCCATCACGAGTCCCCCCA	0.682													14	25					0	0	0	0	A	30584930	A	A	30584930	2	1	70	1	0	0	0	0	0	0	0	1	17504	1045	37	1		1	XKR7	20	30584930	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	16278164	30584930	32440590	373	14527											
MAPRE1	22919	broad.mit.edu	37	chr20	31413815	31413815	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcctggatcaatgagtctCtgcagttgaatctgacaaag	11	11	11	8	0	3	3	1	3	2	0	4	4	3	4	1	2	1	2	1	2	3	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:31413815C>G	uc002wyh.2	+	2	221	c.82C>G	c.(82-84)CTG>GTG	p.L28V		NM_012325	NP_036457	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family,	28	CH.				cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding				0						CAATGAGTCTCTGCAGTTGAA	0.433													43	73					0	0	0	0	G	31413815	G	G	31413815	3	3	70	1	0	0	0	0	1	0	0	0	9347	912	32	2	84	2	MAPRE1	20	31413815	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	828885	31413815	31611705	374	14528											
BPIL1	80341	broad.mit.edu	37	chr20	31607532	31607532	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acagcctccaactcggctttCcagtccctcttctccctgga	6	11	6	18	1	2	0	0	0	2	0	7	1	5	1	5	2	2	1	5	2	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:31607532C>T	uc002wyj.2	+	11	1250	c.1056C>T	c.(1054-1056)TTC>TTT	p.F352F		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	352						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						ACTCGGCTTTCCAGTCCCTCT	0.537													6	27					0	0	0	0	T	31607532	T	T	31607532	2	4	70	1	0	0	0	0	0	0	0	1	1496	854	30	2		2	BPIL1	20	31607532	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	193717	31607532	31417988	375	14529											
SPAG4	6676	broad.mit.edu	37	chr20	34207645	34207646	+	Frame_Shift_Ins	INS	-	C	C																															caccggaggagccaacagcgINSccccccgcgatttcgcggtc																								rs76103999		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:34207645_34207646insC	uc002xdb.1	+	10	1171_1172	c.1054_1055insC	c.(1054-1056)GCCfs	p.A352fs	SPAG4_uc010zvi.1_Frame_Shift_Ins_p.A275fs	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	352	SUN.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			AGCCAACAGCGCCCCCCGCGAT	0.619													---	---	---								C	34207646	C	C	34207645	7	5	70	1	0	1	1	0	0	0	0	0	15046	1087	38	0	1092	0	SPAG4	20	34207645	Frame_Shift_Ins	INS	-	TCGA-CN-6011-01A-11D-1683-08	2600113	34207645	28817875	376	14530											
PTPRT	11122	broad.mit.edu	37	chr20	40980903	40980903	+	Missense_Mutation	SNP	G	A	A																															ggtcagcacttgggtccagcGagccgacagccttgtagttg																										TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:40980903G>A	uc002xkg.2	-	10	1767	c.1583C>T	c.(1582-1584)TCG>TTG	p.S528L	PTPRT_uc010ggj.2_Missense_Mutation_p.S528L	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	528	Extracellular (Potential).|Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGGTCCAGCGAGCCGACAGC	0.532													10	48					0	0	0	0	A	40980903	A	A	40980903	3	1	70	1	0	0	0	0	1	0	0	0	12877	1059	37	1	2891	1	PTPRT	20	40980903	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	6773258	40980903	22044617	377	14531	30	2									
PTPRT	11122	broad.mit.edu	37	chr20	40980908	40980908	+	Silent	SNP	G	T	T																															gcacttgggtccagcgagccGacagccttgtagttgatctg																								rs9941770		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:40980908G>T	uc002xkg.2	-	10	1762	c.1578C>A	c.(1576-1578)GTC>GTA	p.V526V	PTPRT_uc010ggj.2_Silent_p.V526V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	526	Extracellular (Potential).|Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCAGCGAGCCGACAGCCTTGT	0.522													10	48					1.05317e-09	1.11632e-09	1	0	T	40980908	T	T	40980908	2	4	70	1	0	0	0	0	0	0	0	1	12877	1045	37	3		3	PTPRT	20	40980908	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	5	40980908	22044612	378	14532	30	2									
SYCP2	10388	broad.mit.edu	37	chr20	58441392	58441392	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaagactgtgaatctttttCaaaattctccagctcctcta	12	15	4	10	0	4	2	1	1	3	1	6	2	5	2	2	0	1	1	2	0	6	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:58441392C>G	uc002yaz.2	-	40	4415	c.4276G>C	c.(4276-4278)GAA>CAA	p.E1426Q		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1426					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			GAATCTTTTTCAAAATTCTCC	0.229													14	60					0	0	0	0	G	58441392	G	G	58441392	3	3	70	1	0	0	0	0	1	0	0	0	15498	835	29	2	336	2	SYCP2	20	58441392	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	17460484	58441392	4584128	379	14533											
CDH26	60437	broad.mit.edu	37	chr20	58547156	58547156	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcaccgccctgtcgatcGagaaatgacaccatctttca	10	11	7	13	3	3	2	2	1	1	1	5	4	3	2	3	0	0	1	3	0	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:58547156G>T	uc002ybe.2	+	4	671	c.371G>T	c.(370-372)CGA>CTA	p.R124L	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	124	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CCTGTCGATCGAGAAATGACA	0.383													15	49					3.52763e-06	3.68392e-06	1	0	T	58547156	T	T	58547156	3	4	70	1	0	0	0	0	1	0	0	0	3125	1058	37	3	385	3	CDH26	20	58547156	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	105764	58547156	4478364	380	14534											
DIDO1	11083	broad.mit.edu	37	chr20	61511034	61511034	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctctttgggccccacgtCaaaccgctctctctgcctcc	4	12	6	19	2	4	0	1	0	3	0	7	0	5	0	5	1	2	1	5	1	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:61511034C>G	uc002ydr.1	-	16	6538	c.6274G>C	c.(6274-6276)GAC>CAC	p.D2092H	DIDO1_uc002yds.1_Missense_Mutation_p.D2092H	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	2092					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GGCCCCACGTCAAACCGCTCT	0.612													42	270					0	0	0	0	G	61511034	G	G	61511034	3	3	70	1	0	0	0	0	1	0	0	0	4544	826	29	2	452	2	DIDO1	20	61511034	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	2963878	61511034	1514486	381	14535											
ARFRP1	10139	broad.mit.edu	37	chr20	62338354	62338354	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggcgtgggcactcaccgtCttcccagcattgtccaggcc	6	8	12	15	2	2	0	1	0	1	0	4	0	4	0	4	3	1	2	4	3	0	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:62338354C>G	uc002yga.2	-	1	657	c.90G>C	c.(88-90)AAG>AAC	p.K30N	ARFRP1_uc002ygc.2_Missense_Mutation_p.K30N|ARFRP1_uc002ygh.3_Missense_Mutation_p.K30N|ARFRP1_uc011abf.1_Missense_Mutation_p.K30N|ARFRP1_uc011abg.1_Missense_Mutation_p.K30N|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Missense_Mutation_p.K30N|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA|ZGPAT_uc002ygi.2_5'Flank|ZGPAT_uc002ygj.2_5'Flank|ZGPAT_uc002ygk.2_5'Flank|ZGPAT_uc010gkk.1_5'Flank|ZGPAT_uc010gkl.1_5'Flank|ZGPAT_uc002ygm.2_5'Flank|ZGPAT_uc002ygn.3_5'Flank	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	30	GTP (By similarity).				small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			CACTCACCGTCTTCCCAGCAT	0.607													7	22					0	0	0	0	G	62338354	G	G	62338354	3	3	70	1	0	0	0	0	1	0	0	0	856	912	32	2	547	2	ARFRP1	20	62338354	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	827320	62338354	687166	382	14536											
ZBTB46	140685	broad.mit.edu	37	chr20	62421736	62421736	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgatgtccagcgccgccttGatgaagtcgtggcaggcttg	6	10	14	11	3	0	3	0	3	0	0	2	3	1	3	3	2	1	2	3	2	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:62421736G>C	uc002ygv.1	-	2	576	c.375C>G	c.(373-375)ATC>ATG	p.I125M	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					GCGCCGCCTTGATGAAGTCGT	0.612													5	22					0	0	0	0	C	62421736	C	C	62421736	3	2	70	1	0	0	0	0	1	0	0	0	17614	1280	45	2	1410	2	ZBTB46	20	62421736	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	83382	62421736	603784	383	14537											
TPTE	7179	broad.mit.edu	37	chr21	10951399	10951400	+	Missense_Mutation	DNP	CC	TT	TT																															ggcaaggatgagagtgacatCcagtaagaccaggaaaactc																										TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr21:10951399_10951400CC>TT	uc002yip.1	-	10	680_681	c.312_313GG>AA	c.(310-315)CTGGAT>CTAAAT	p.D105N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.D87N|TPTE_uc002yir.1_Missense_Mutation_p.D67N|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	105	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGAGTGACATCCAGTAAGACCA	0.322													18	113					0	0	0	0	TT	10951400	TT	TT	10951399	3	4	70	1	0	0	0	0	1	0	0	0	16497	855	30	2	1402	2	TPTE	21	10951399	Missense_Mutation	DNP	CC	TCGA-CN-6011-01A-11D-1683-08		10951399	37178496	384	14538											
KRTAP22-1	337979	broad.mit.edu	37	chr21	31973557	31973557	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctactgcccatggtgttatGaaagatcttggttttctggc	7	15	11	8	0	2	2	0	1	2	1	2	2	2	2	1	3	2	3	1	3	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr21:31973557G>A	uc011add.1	+	1	118	c.118G>A	c.(118-120)GAA>AAA	p.E40K	KRTAP6-2_uc011adc.1_5'Flank	NM_181620	NP_853651	Q3MIV0	KR221_HUMAN	keratin associated protein 22-1	40						intermediate filament					0						ATGGTGTTATGAAAGATCTTG	0.483													37	155					0	0	0	0	A	31973557	A	A	31973557	3	1	70	1	0	0	0	0	1	0	0	0	8579	1291	45	2	120	2	KRTAP22-1	21	31973557	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	21022158	31973557	16156338	385	14539											
SIM2	6493	broad.mit.edu	37	chr21	38072060	38072060	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aggcgcgatgaaggagaagtCcaagaatgcggccaagacca	15	3	14	9	3	0	4	0	1	0	3	1	6	1	4	3	3	1	0	3	3	5	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr21:38072060C>G	uc002yvr.2	+	1	70	c.14C>G	c.(13-15)TCC>TGC	p.S5C	SIM2_uc002yvp.2_Missense_Mutation_p.S5C|SIM2_uc002yvq.2_Missense_Mutation_p.S5C	NM_005069	NP_005060	Q14190	SIM2_HUMAN	single-minded homolog 2 long isoform	5	Basic motif.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1						AAGGAGAAGTCCAAGAATGCG	0.662													3	15					0	0	0	0	G	38072060	G	G	38072060	3	3	70	1	0	0	0	0	1	0	0	0	14389	855	30	2	16	2	SIM2	21	38072060	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	6098503	38072060	10057835	386	14540											
AGPAT3	56894	broad.mit.edu	37	chr21	45387862	45387862	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggagtggtggtcctgcacgGagtgtacactgttcacggac	7	10	15	9	2	1	0	1	0	0	0	2	3	2	3	1	5	2	3	1	5	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr21:45387862G>A	uc002zdv.2	+	4	436	c.214G>A	c.(214-216)GAG>AAG	p.E72K	AGPAT3_uc002zdw.2_Missense_Mutation_p.E72K|AGPAT3_uc002zdx.2_Missense_Mutation_p.E159K|AGPAT3_uc002zdy.2_Missense_Mutation_p.E10K	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	72	Cytoplasmic (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		GTCCTGCACGGAGTGTACACT	0.612													11	22					0	0	0	0	A	45387862	A	A	45387862	3	1	70	1	0	0	0	0	1	0	0	0	388	1175	41	2	220	2	AGPAT3	21	45387862	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	7315802	45387862	2742033	387	14541											
CABIN1	23523	broad.mit.edu	37	chr22	24563212	24563212	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtgtgtggcagcagggccaGaagggtgtggcctatgacct	7	8	17	9	1	0	2	0	1	0	1	0	2	0	2	3	4	1	2	3	4	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:24563212G>A	uc002zzi.1	+	32	5740	c.5613G>A	c.(5611-5613)CAG>CAA	p.Q1871Q	CABIN1_uc002zzj.1_Silent_p.Q1792Q|CABIN1_uc002zzl.1_Silent_p.Q1871Q|CABIN1_uc002zzm.1_Silent_p.Q296Q	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1871					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						AGCAGGGCCAGAAGGGTGTGG	0.617													3	43					0	0	0	0	A	24563212	A	A	24563212	2	1	70	1	0	0	0	0	0	0	0	1	2540	933	33	2		2	CABIN1	22	24563212	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08		24563212	26741354	388	14542											
C22orf30	253143	broad.mit.edu	37	chr22	32100665	32100665	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgactgccgctggtgttaTatgtagcttccatgcctgga	6	14	11	10	1	1	1	0	1	1	0	2	2	2	2	3	2	3	4	3	2	3	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:32100665T>C	uc003alp.3	-	5	5997	c.5804A>G	c.(5803-5805)TAT>TGT	p.Y1935C	C22orf30_uc003alo.1_Missense_Mutation_p.Y1734C|C22orf30_uc010gwj.1_Missense_Mutation_p.Y1734C	NM_173566	NP_775837	Q5THK1	PR14L_HUMAN	hypothetical protein LOC253143	1935											0						GCTGGTGTTATATGTAGCTTC	0.403													9	43					0	0	0	0	C	32100665	C	C	32100665	3	2	70	1	0	0	0	0	1	0	0	0	2152	1406	49	5	671	5	C22orf30	22	32100665	Missense_Mutation	SNP	T	TCGA-CN-6011-01A-11D-1683-08	7537453	32100665	19203901	389	14543											
BPIL2	254240	broad.mit.edu	37	chr22	32831730	32831730	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acattgaaaaccccagctgtGaaatgagcaaaggacgcaga	17	5	10	9	1	0	4	0	3	0	1	0	5	0	5	2	1	3	3	2	1	4	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:32831730G>A	uc003amn.2	-	8	885	c.885C>T	c.(883-885)TTC>TTT	p.F295F	BPIL2_uc010gwo.2_Silent_p.F109F|BPIL2_uc011amb.1_Silent_p.F19F	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	295						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						CCCCAGCTGTGAAATGAGCAA	0.458													17	19					0	0	0	0	A	32831730	A	A	32831730	2	1	70	1	0	0	0	0	0	0	0	1	1497	1281	45	2		2	BPIL2	22	32831730	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	731065	32831730	18472836	390	14544											
NOL12	79159	broad.mit.edu	37	chr22	38084953	38084953	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccgtgaccaccatcagtgAcctggacctctcgggggccc	7	6	11	17	2	2	2	1	2	1	0	3	3	2	3	6	3	0	0	6	3	0	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:38084953A>G	uc003atp.2	+	4	391	c.335A>G	c.(334-336)GAC>GGC	p.D112G	NOL12_uc011anm.1_Missense_Mutation_p.D112G|NOL12_uc003ato.1_RNA|TRIOBP_uc003atq.1_5'UTR	NM_024313	NP_077289	Q9UGY1	NOL12_HUMAN	nucleolar protein 12	112						nucleolus	rRNA binding				0	Melanoma(58;0.0574)					ACCATCAGTGACCTGGACCTC	0.647													32	109					0	0	0	0	G	38084953	G	G	38084953	3	3	70	1	0	0	0	0	1	0	0	0	10576	275	10	5	349	5	NOL12	22	38084953	Missense_Mutation	SNP	A	TCGA-CN-6011-01A-11D-1683-08	5253223	38084953	13219613	391	14545											
MKL1	57591	broad.mit.edu	37	chr22	40816946	40816946	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagagctgctgctgctgcagGatcttggcgtaggatgagtc	8	10	15	8	1	1	2	0	1	1	1	2	4	1	4	0	3	5	6	0	3	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:40816946G>T	uc003ayv.1	-	7	993	c.786C>A	c.(784-786)ATC>ATA	p.I262I	MKL1_uc003ayw.1_Silent_p.I262I|MKL1_uc010gye.1_Silent_p.I262I|MKL1_uc010gyf.1_Silent_p.I212I	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	262					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCTGCTGCAGGATCTTGGCGT	0.602			T	RBM15	acute megakaryocytic leukemia								34	15					1.26612e-14	1.36542e-14	1	0	T	40816946	T	T	40816946	2	4	70	1	0	0	0	0	0	0	0	1	9654	1164	41	2		2	MKL1	22	40816946	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	2731993	40816946	10487620	392	14546											
MKL1	57591	broad.mit.edu	37	chr22	40816975	40816975	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtaggatgagtccatgggggGtgcccccctgtcctgcttct	4	11	14	12	0	1	1	0	1	1	0	3	2	3	2	5	4	2	2	5	4	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:40816975G>A	uc003ayv.1	-	7	964	c.757C>T	c.(757-759)CCC>TCC	p.P253S	MKL1_uc003ayw.1_Missense_Mutation_p.P253S|MKL1_uc010gye.1_Missense_Mutation_p.P253S|MKL1_uc010gyf.1_Missense_Mutation_p.P203S	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	253	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TCCATGGGGGGTGCCCCCCTG	0.592			T	RBM15	acute megakaryocytic leukemia								32	25					0	0	0	0	A	40816975	A	A	40816975	3	1	70	1	0	0	0	0	1	0	0	0	9654	1261	44	4	2062	4	MKL1	22	40816975	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	29	40816975	10487591	393	14547											
SBF1	6305	broad.mit.edu	37	chr22	50904631	50904631	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccccaatgatgaagggcGtgggtgtgctgaggacctcc	8	8	15	10	1	0	4	0	4	0	0	1	5	1	5	4	3	1	1	4	3	2	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:50904631G>A	uc003blh.2	-	8	1040	c.845C>T	c.(844-846)ACG>ATG	p.T282M	SBF1_uc011arx.1_Translation_Start_Site|SBF1_uc003bli.2_Missense_Mutation_p.T283M	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	282	DENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GATGAAGGGCGTGGGTGTGCT	0.652													20	42					0	0	0	0	A	50904631	A	A	50904631	3	1	70	1	0	0	0	0	1	0	0	0	13923	1145	40	1	4972	1	SBF1	22	50904631	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	10087656	50904631	399935	394	14548											
ASMTL	8623	broad.mit.edu	37	chrX	1546872	1546872	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gacactccgccgcaggtcctCcggacggggcgggtagtaga	7	5	16	13	5	0	1	0	0	0	1	3	3	3	2	4	5	0	3	4	5	2	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:1546872C>G	uc004cpx.1	-	7	763	c.652G>C	c.(652-654)GAG>CAG	p.E218Q	ASMTL_uc011mhe.1_Missense_Mutation_p.E142Q|ASMTL_uc004cpy.1_Missense_Mutation_p.E202Q|ASMTL_uc011mhf.1_Missense_Mutation_p.E160Q	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	218	MAF-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGCAGGTCCTCCGGACGGGGC	0.647													16	40					0	0	0	0	G	1546872	G	G	1546872	3	3	70	1	0	0	0	0	1	0	0	0	1048	864	30	2	1241	2	ASMTL	23	1546872	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08		1546872	153723688	395	14549											
NHS	4810	broad.mit.edu	37	chrX	17745088	17745088	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctggctcctaaatgacttGaaaacaaatgatccttatag	14	12	6	9	0	1	3	0	3	1	0	3	3	3	3	2	1	1	1	2	1	7	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:17745088G>C	uc004cxx.2	+	6	3137	c.2799G>C	c.(2797-2799)TTG>TTC	p.L933F	NHS_uc011mix.1_Missense_Mutation_p.L954F|NHS_uc004cxy.2_Missense_Mutation_p.L777F|NHS_uc004cxz.2_Missense_Mutation_p.L756F|NHS_uc004cya.2_Missense_Mutation_p.L656F	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	933						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					TAAATGACTTGAAAACAAATG	0.423													82	19					0	0	0	0	C	17745088	C	C	17745088	3	2	70	1	0	0	0	0	1	0	0	0	10465	1281	45	2	2926	2	NHS	23	17745088	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	16198216	17745088	137525472	396	14550											
SCML1	6322	broad.mit.edu	37	chrX	17762333	17762333	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tctaacagctccagtgaaatCgatgtggtttgtattcaaat	12	14	8	7	1	2	1	1	1	1	0	4	2	3	1	1	1	2	3	1	1	4	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:17762333C>G	uc004cyb.2	+	2	352	c.27C>G	c.(25-27)ATC>ATG	p.I9M	SCML1_uc004cyc.2_Missense_Mutation_p.I9M|SCML1_uc004cyd.2_Intron|SCML1_uc004cye.2_Intron	NM_001037540	NP_001032629	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 isoform a	9					anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)	3	Hepatocellular(33;0.183)					CCAGTGAAATCGATGTGGTTT	0.328													19	29					0	0	0	0	G	17762333	G	G	17762333	3	3	70	1	0	0	0	0	1	0	0	0	13974	874	31	3	29	3	SCML1	23	17762333	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	17245	17762333	137508227	397	14551											
SCML1	6322	broad.mit.edu	37	chrX	17768106	17768106	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtttacgagacattctcCtaccctgaaagttacagccc	11	10	8	12	1	1	2	0	1	1	1	2	4	1	2	3	1	4	2	3	1	4	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:17768106C>G	uc004cyb.2	+	6	721	c.396C>G	c.(394-396)TCC>TCG	p.S132S	SCML1_uc004cyc.2_Silent_p.S105S|SCML1_uc004cyd.2_Silent_p.S11S|SCML1_uc004cye.2_Silent_p.S11S	NM_001037540	NP_001032629	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 isoform a	132					anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)	3	Hepatocellular(33;0.183)					AGACATTCTCCTACCCTGAAA	0.418													32	56					0	0	0	0	G	17768106	G	G	17768106	2	3	70	1	0	0	0	0	0	0	0	1	13974	668	24	4		4	SCML1	23	17768106	Silent	SNP	C	TCGA-CN-6011-01A-11D-1683-08	5773	17768106	137502454	398	14552											
MAGEB16	139604	broad.mit.edu	37	chrX	35820840	35820841	+	Missense_Mutation	DNP	CC	GA	GA																															tgtggtggaggtggaccccaCcacccattgctatggcctct																										TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:35820840_35820841CC>GA	uc010ngt.1	+	2	806_807	c.527_528CC>GA	c.(526-528)ACC>AGA	p.T176R		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	176	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						GTGGACCCCACCACCCATTGCT	0.51													8	17					0	0	0	0	GA	35820841	GA	GA	35820840	3	3	70	1	0	0	0	0	1	0	0	0	9227	507	18	4	529	4	MAGEB16	23	35820840	Missense_Mutation	DNP	CC	TCGA-CN-6011-01A-11D-1683-08	18052734	35820840	119449720	399	14553											
ATRX	546	broad.mit.edu	37	chrX	76776376	76776376	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtacttgggcctctgagaGattcatgttctccttccact	6	15	8	12	0	3	2	1	1	2	1	5	3	4	2	3	1	1	2	3	1	1	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:76776376G>A	uc004ecp.3	-	34	7322	c.7090C>T	c.(7090-7092)CTC>TTC	p.L2364F	ATRX_uc004ecq.3_Missense_Mutation_p.L2326F|ATRX_uc004eco.3_Missense_Mutation_p.L2149F	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2364					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GCCTCTGAGAGATTCATGTTC	0.348			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						21	12					0	0	0	0	A	76776376	A	A	76776376	3	1	70	1	0	0	0	0	1	0	0	0	1210	942	33	2	396	2	ATRX	23	76776376	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	40955536	76776376	78494184	400	14554											
LPAR4	2846	broad.mit.edu	37	chrX	78010388	78010388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggtgacagaagattcattGacttccaattccaagattca	13	12	8	8	0	2	5	2	2	0	3	4	5	4	5	2	1	0	0	2	1	3	5			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:78010388G>A	uc010nme.2	+	2	427	c.22G>A	c.(22-24)GAC>AAC	p.D8N		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	8	Extracellular (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						AAGATTCATTGACTTCCAATT	0.438													14	23					0	0	0	0	A	78010388	A	A	78010388	3	1	70	1	0	0	0	0	1	0	0	0	8957	1290	45	2	24	2	LPAR4	23	78010388	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	1234012	78010388	77260172	401	14555											
DRP2	1821	broad.mit.edu	37	chrX	100496666	100496666	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcttgcagatacctcccCgaaacagcggatccagaatc	11	8	7	15	2	1	2	0	0	1	2	5	4	4	3	5	1	4	1	5	1	3	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:100496666C>T	uc004egz.2	+	7	938	c.569C>T	c.(568-570)CCG>CTG	p.P190L	DRP2_uc011mrh.1_Missense_Mutation_p.P112L	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	190					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						GATACCTCCCCGAAACAGCGG	0.527													10	39					0	0	0	0	T	100496666	T	T	100496666	3	4	70	1	0	0	0	0	1	0	0	0	4786	652	23	1	587	1	DRP2	23	100496666	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	22486278	100496666	54773894	402	14556											
NRK	203447	broad.mit.edu	37	chrX	105179293	105179293	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaaaaggagttcacttctGagatctgctgtggttctttg	9	15	11	6	0	4	2	1	2	3	1	4	4	4	3	0	2	1	3	0	2	2	4			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:105179293G>T	uc004emd.2	+	21	3934	c.3631G>T	c.(3631-3633)GAG>TAG	p.E1211*	NRK_uc010npc.1_Nonsense_Mutation_p.E879*	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1211	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GTTCACTTCTGAGATCTGCTG	0.353										HNSCC(51;0.14)			20	11					5.03518e-11	5.37159e-11	1	0	T	105179293	T	T	105179293	4	4	70	1	0	0	0	0	0	1	0	0	10709	1291	45	2	3713	2	NRK	23	105179293	Nonsense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	4682627	105179293	50091267	403	14557											
LUZP4	51213	broad.mit.edu	37	chrX	114540829	114540829	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aatcaaggccagtcagagggGaaccagcatcaatcagaagg	16	4	12	9	0	4	2	4	0	0	2	4	3	4	3	2	4	2	1	2	4	5	0			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:114540829G>A	uc004eqa.2	+	4	436	c.402G>A	c.(400-402)GGG>GGA	p.G134G	LUZP4_uc004eqb.2_Silent_p.G52G	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	134						nucleus				ovary(2)	2						AGTCAGAGGGGAACCAGCATC	0.433													18	24					0	0	0	0	A	114540829	A	A	114540829	2	1	70	1	0	0	0	0	0	0	0	1	9138	1161	41	2		2	LUZP4	23	114540829	Silent	SNP	G	TCGA-CN-6011-01A-11D-1683-08	9361536	114540829	40729731	404	14558											
GLUD2	2747	broad.mit.edu	37	chrX	120183061	120183061	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagaaagacattgtgcactCtgccttggcatacacaatgg	12	10	10	9	0	1	2	0	1	1	2	1	3	1	2	1	2	3	2	1	2	3	3			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:120183061C>G	uc004eto.2	+	1	1600	c.1523C>G	c.(1522-1524)TCT>TGT	p.S508C		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	508					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATTGTGCACTCTGCCTTGGCA	0.463													31	24					0	0	0	0	G	120183061	G	G	120183061	3	3	70	1	0	0	0	0	1	0	0	0	6514	913	32	2	1525	2	GLUD2	23	120183061	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	5642232	120183061	35087499	405	14559											
GPR112	139378	broad.mit.edu	37	chrX	135427079	135427079	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagacaacatctttattttCaactattgagtcaacatcta	15	14	4	8	0	4	2	2	1	2	1	4	3	4	2	0	0	3	0	0	0	7	7			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:135427079C>G	uc004ezu.1	+	6	1505	c.1214C>G	c.(1213-1215)TCA>TGA	p.S405*	GPR112_uc010nsb.1_Nonsense_Mutation_p.S200*|GPR112_uc010nsc.1_Nonsense_Mutation_p.S172*	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	405	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TCTTTATTTTCAACTATTGAG	0.388													25	49					0	0	0	0	G	135427079	G	G	135427079	4	3	70	1	0	0	0	0	0	1	0	0	6667	838	29	2	1224	2	GPR112	23	135427079	Nonsense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	15244018	135427079	19843481	406	14560											
CXorf40A	91966	broad.mit.edu	37	chrX	148628500	148628500	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctgatcccattggggcatGaagtgtgacaagtgtgggct	9	10	14	8	0	0	3	0	3	0	0	1	3	1	3	2	3	0	2	2	3	2	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:148628500G>C	uc004fdb.2	+	5	741	c.469G>C	c.(469-471)GAA>CAA	p.E157Q	CXorf40A_uc011mxm.1_Missense_Mutation_p.E157Q|CXorf40A_uc011mxn.1_Missense_Mutation_p.E157Q|CXorf40A_uc004fdd.2_Missense_Mutation_p.E157Q|CXorf40A_uc004fde.1_Intron|CXorf40A_uc004fdg.2_Missense_Mutation_p.E157Q|CXorf40A_uc004fdf.2_Missense_Mutation_p.E157Q|CXorf40A_uc004fdh.2_Intron|CXorf40A_uc010nsy.2_Missense_Mutation_p.E157Q|CXorf40A_uc004fdi.2_Missense_Mutation_p.E174Q	NM_178124	NP_835225	Q8TE69	CX04A_HUMAN	chromosome X open reading frame 40	157							protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					ATTGGGGCATGAAGTGTGACA	0.478													4	11					0	0	0	0	C	148628500	C	C	148628500	3	2	70	1	0	0	0	0	1	0	0	0	4125	1291	45	2	475	2	CXorf40A	23	148628500	Missense_Mutation	SNP	G	TCGA-CN-6011-01A-11D-1683-08	13201421	148628500	6642060	407	14561											
CXorf40B	541578	broad.mit.edu	37	chrX	149100770	149100770	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcccacacttgtcacacttCatgccccaaagggatcaggt	11	8	8	14	0	3	0	3	0	0	0	3	1	3	1	3	2	2	0	3	2	1	2			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:149100770C>G	uc004fdy.2	-	5	985	c.469G>C	c.(469-471)GAA>CAA	p.E157Q	CXorf40B_uc011mxs.1_Intron	NM_001013845	NP_001013867	Q96DE9	CX04B_HUMAN	hypothetical protein LOC541578	157											0	Acute lymphoblastic leukemia(192;6.56e-05)					TGTCACACTTCATGCCCCAAA	0.483													13	84					0	0	0	0	G	149100770	G	G	149100770	3	3	70	1	0	0	0	0	1	0	0	0	4126	835	29	2	11	2	CXorf40B	23	149100770	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	472270	149100770	6169790	408	14562											
PLXNB3	5365	broad.mit.edu	37	chrX	153035337	153035337	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttatgaggaggacagccaCtgcctgcacatccagagcct	11	7	11	12	0	0	2	0	1	0	1	1	4	1	4	4	2	4	2	4	2	1	1			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:153035337C>G	uc004fii.2	+	7	1746	c.1572C>G	c.(1570-1572)CAC>CAG	p.H524Q	PLXNB3_uc011mzb.1_Missense_Mutation_p.H60Q|PLXNB3_uc011mzc.1_Missense_Mutation_p.H206Q|PLXNB3_uc010nuk.2_Missense_Mutation_p.H547Q|PLXNB3_uc011mzd.1_Missense_Mutation_p.H163Q	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	524	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGACAGCCACTGCCTGCACA	0.687													4	7					0	0	0	0	G	153035337	G	G	153035337	3	3	70	1	0	0	0	0	1	0	0	0	12180	564	20	4	1712	4	PLXNB3	23	153035337	Missense_Mutation	SNP	C	TCGA-CN-6011-01A-11D-1683-08	3934567	153035337	2235223	409	14563											
PRDM16	63976	broad.mit.edu	37	chr1	2985742	2985742	+	5'Flank	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgtgcgaaggtgtccaaaCtgacaatgctggggagatga	12	8	14	7	1	0	3	0	2	0	1	1	5	1	3	1	3	3	1	1	3	3	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:2985742C>G	uc001akf.2	+						PRDM16_uc001akc.2_5'Flank|PRDM16_uc001akd.2_5'Flank|PRDM16_uc001ake.2_5'Flank|PRDM16_uc009vlh.2_5'Flank|FLJ42875_uc010nzg.1_5'Flank	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1						brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GGTGTCCAAACTGACAATGCT	0.532			T	EVI1	MDS|AML								3	9					0	0	0	0	G	2985742	G	G	2985742	1	3	71	0	1	0	0	0	0	0	0	0	12519	579	20	4		4	PRDM16	1	2985742	5'Flank	SNP	C	TCGA-CN-6012-01A-11D-1683-08		2985742	246264879	1	14564											
PIK3CD	5293	broad.mit.edu	37	chr1	9784117	9784117	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcattggcgatcggcaCagcgacaacatcatgatccg	10	7	12	12	4	1	1	1	1	0	0	3	3	2	1	1	3	2	2	1	3	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:9784117C>T	uc001aqb.3	+	21	2893	c.2685C>T	c.(2683-2685)CAC>CAT	p.H895H	PIK3CD_uc010oaf.1_Silent_p.H894H|PIK3CD_uc001aqe.3_Silent_p.H919H	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	895	PI3K/PI4K.				phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GCGATCGGCACAGCGACAACA	0.632													57	54					0	0	0	0	T	9784117	T	T	9784117	2	4	71	1	0	0	0	0	0	0	0	1	11970	477	17	4		4	PIK3CD	1	9784117	Silent	SNP	C	TCGA-CN-6012-01A-11D-1683-08	6798375	9784117	239466504	2	14565											
HFM1	164045	broad.mit.edu	37	chr1	91727880	91727880	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagaatttgggtttttttCagagaaagtaaagcattgct	13	15	10	3	0	1	3	1	1	0	2	1	4	1	3	0	1	2	4	0	1	5	6			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:91727880C>T	uc001doa.3	-	38	4256	c.4156G>A	c.(4156-4158)GAA>AAA	p.E1386K	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.E1065K|HFM1_uc001dob.3_Missense_Mutation_p.E574K	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1386							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GGGTTTTTTTCAGAGAAAGTA	0.284													10	58					0	0	0	0	T	91727880	T	T	91727880	3	4	71	1	0	0	0	0	1	0	0	0	7122	835	29	2	159	2	HFM1	1	91727880	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	81943763	91727880	157522741	3	14566											
HFM1	164045	broad.mit.edu	37	chr1	91728133	91728133	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaagaaatatccgacatctCatgtgatgaaacaaaactaa	20	9	5	7	1	1	3	1	2	1	1	3	4	2	3	1	0	2	0	1	0	8	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:91728133C>G	uc001doa.3	-	37	4091	c.3991G>C	c.(3991-3993)GAG>CAG	p.E1331Q	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.E1010Q|HFM1_uc001dob.3_Missense_Mutation_p.E519Q	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1331							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TCCGACATCTCATGTGATGAA	0.303													8	59					0	0	0	0	G	91728133	G	G	91728133	3	3	71	1	0	0	0	0	1	0	0	0	7122	835	29	2	328	2	HFM1	1	91728133	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	253	91728133	157522488	4	14567											
FAM102B	284611	broad.mit.edu	37	chr1	109167328	109167328	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgaatctttgcaagaagatAgaaaaggtggagagactctc	15	9	11	6	0	2	5	0	1	2	4	3	7	2	6	0	2	1	1	0	2	6	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:109167328A>G	uc010ouy.1	+	6	594	c.514A>G	c.(514-516)AGA>GGA	p.R172G		NM_001010883	NP_001010883	Q5T8I3	F102B_HUMAN	hypothetical protein LOC284611	172										large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		GCAAGAAGATAGAAAAGGTGG	0.423													26	39					0	0	0	0	G	109167328	G	G	109167328	3	3	71	1	0	0	0	0	1	0	0	0	5411	412	15	5	536	5	FAM102B	1	109167328	Missense_Mutation	SNP	A	TCGA-CN-6012-01A-11D-1683-08	17439195	109167328	140083293	5	14568											
MEX3A	92312	broad.mit.edu	37	chr1	156046882	156046882	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgtggggcctcaaagccaGagtccactccgcactcgccg	7	5	13	16	4	1	1	1	0	0	1	4	1	3	1	5	3	1	1	5	3	1	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:156046882G>A	uc001fnd.3	-	2	1046	c.1046C>T	c.(1045-1047)TCT>TTT	p.S349F		NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	349						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					CTCAAAGCCAGAGTCCACTCC	0.672													6	84					0	0	0	0	A	156046882	A	A	156046882	3	1	71	1	0	0	0	0	1	0	0	0	9562	942	33	2	520	2	MEX3A	1	156046882	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	46879554	156046882	93203739	6	14569											
FCGR2B	2213	broad.mit.edu	37	chr1	161642856	161642856	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaaggacaagcctctggtCaaggtcacattcttccagaa	12	9	10	10	0	4	1	2	0	2	1	5	3	5	3	2	4	1	0	2	4	4	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:161642856C>G	uc001gaz.1	+	4	575	c.483C>G	c.(481-483)GTC>GTG	p.V161V	FCGR2B_uc009wum.1_Silent_p.V161V|FCGR2B_uc001gay.1_Silent_p.V160V|FCGR2B_uc001gba.1_Silent_p.V160V|FCGR2B_uc001gbb.1_Silent_p.V161V|FCGR2B_uc009wun.1_Silent_p.V154V	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	161	Ig-like C2-type 2.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGCCTCTGGTCAAGGTCACAT	0.522			T	?	ALL								7	22					0	0	0	0	G	161642856	G	G	161642856	2	3	71	1	0	0	0	0	0	0	0	1	5814	813	29	2		2	FCGR2B	1	161642856	Silent	SNP	C	TCGA-CN-6012-01A-11D-1683-08	5595974	161642856	87607765	7	14570											
ASPM	259266	broad.mit.edu	37	chr1	197091047	197091047	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatattctaggagtacctGatggcgtttgagatctgttt	8	17	10	6	1	3	2	1	2	2	1	3	4	3	3	1	2	1	3	1	2	3	7			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:197091047G>A	uc001gtu.2	-	16	4125	c.3868C>T	c.(3868-3870)CAG>TAG	p.Q1290*	ASPM_uc001gtv.2_Nonsense_Mutation_p.Q1290*|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1290					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						AGGAGTACCTGATGGCGTTTG	0.318													4	61					0	0	0	0	A	197091047	A	A	197091047	4	1	71	1	0	0	0	0	0	1	0	0	1058	1299	45	2	6617	2	ASPM	1	197091047	Nonsense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	35448191	197091047	52159574	8	14571											
FMN2	56776	broad.mit.edu	37	chr1	240256692	240256692	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccacccggcagctcagctCgcccaatcactccccgtctc	7	6	6	22	3	3	0	2	0	1	0	6	0	4	0	5	1	2	3	5	1	1	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:240256692C>T	uc010pyd.1	+	1	1508	c.1283C>T	c.(1282-1284)TCG>TTG	p.S428L	FMN2_uc010pye.1_Missense_Mutation_p.S428L	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	428					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGCTCAGCTCGCCCAATCAC	0.667													6	64					0	0	0	0	T	240256692	T	T	240256692	3	4	71	1	0	0	0	0	1	0	0	0	5982	893	31	1	1285	1	FMN2	1	240256692	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	43165645	240256692	8993929	9	14572											
EXO1	9156	broad.mit.edu	37	chr1	242016725	242016725	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggggaaagtctcggaagctcGagagtgtttcacccggtcta	9	9	14	9	3	3	1	1	0	2	1	5	4	3	3	1	4	1	2	1	4	3	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:242016725G>C	uc001hzh.2	+	6	887	c.347G>C	c.(346-348)CGA>CCA	p.R116P	EXO1_uc001hzi.2_Missense_Mutation_p.R116P|EXO1_uc001hzj.2_Missense_Mutation_p.R116P|EXO1_uc009xgq.2_Missense_Mutation_p.R116P	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	116					meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			TCGGAAGCTCGAGAGTGTTTC	0.423								Direct_reversal_of_damage|Editing_and_processing_nucleases					12	85					0	0	0	0	C	242016725	C	C	242016725	3	2	71	1	0	0	0	0	1	0	0	0	5324	1058	37	3	357	3	EXO1	1	242016725	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	1760033	242016725	7233896	10	14573											
C1orf101	257044	broad.mit.edu	37	chr1	244641251	244641251	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcctcacctggtgttcacGctataaaaccaattgttact	10	14	6	11	1	2	0	2	0	0	0	3	0	3	0	3	1	2	4	3	1	5	6			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:244641251G>A	uc001iam.2	+	4	291	c.232G>A	c.(232-234)GCT>ACT	p.A78T	C1orf101_uc001iak.1_5'UTR|C1orf101_uc001ial.2_Missense_Mutation_p.A78T|C1orf101_uc010pym.1_5'UTR|C1orf101_uc010pyn.1_Missense_Mutation_p.A81T	NM_001130957	NP_001124429	Q5SY80	CA101_HUMAN	hypothetical protein LOC257044 isoform 1	78	Extracellular (Potential).					integral to membrane				ovary(1)|breast(1)	2	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			TGGTGTTCACGCTATAAAACC	0.318													6	84					0	0	0	0	A	244641251	A	A	244641251	3	1	71	1	0	0	0	0	1	0	0	0	1985	1087	38	1	246	1	C1orf101	1	244641251	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	2624526	244641251	4609370	11	14574											
HADHA	3030	broad.mit.edu	37	chr2	26455030	26455030	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggggatgttagactcaccaTtttgggcagcctttgtgtgc	7	13	13	8	0	1	1	1	0	0	1	1	2	1	2	2	3	2	2	2	3	1	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr2:26455030T>C	uc002rgy.2	-	6	701	c.571A>G	c.(571-573)ATG>GTG	p.M191V	HADHA_uc010yks.1_Missense_Mutation_p.M104V|HADHA_uc010ykt.1_Missense_Mutation_p.M104V	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	191					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	AGACTCACCATTTTGGGCAGC	0.398													13	31					0	0	0	0	C	26455030	C	C	26455030	3	2	71	1	0	0	0	0	1	0	0	0	6982	1493	52	5	1780	5	HADHA	2	26455030	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08		26455030	216744343	12	14575											
KIF5C	3800	broad.mit.edu	37	chr2	149850992	149850992	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacatggaacagaagaggAggcagctagaagagtcccag	17	3	14	7	0	0	5	0	0	0	5	1	7	1	7	1	3	3	2	1	3	5	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr2:149850992A>G	uc010zbu.1	+	17	2331	c.1963A>G	c.(1963-1965)AGG>GGG	p.R655G	KIF5C_uc002tws.1_RNA|KIF5C_uc002twt.2_Missense_Mutation_p.R207G	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	655					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		ACAGAAGAGGAGGCAGCTAGA	0.493													2	7					0	0	0	0	G	149850992	G	G	149850992	3	3	71	1	0	0	0	0	1	0	0	0	8346	295	11	5	1951	5	KIF5C	2	149850992	Missense_Mutation	SNP	A	TCGA-CN-6012-01A-11D-1683-08	123395962	149850992	93348381	13	14576											
RIF1	55183	broad.mit.edu	37	chr2	152289598	152289598	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attttcttttaagatatactAtgtagtgcaaaaagactcaa	16	15	5	5	0	2	2	1	0	1	2	2	2	2	2	0	0	2	2	0	0	8	8			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr2:152289598A>G	uc002txm.2	+	10	1063	c.933A>G	c.(931-933)CTA>CTG	p.L311L	RIF1_uc002txl.2_Silent_p.L311L|RIF1_uc010fnv.1_Silent_p.L275L|RIF1_uc002txn.2_Silent_p.L311L|RIF1_uc002txo.2_Silent_p.L311L|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	311					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AAGATATACTATGTAGTGCAA	0.358													8	32					0	0	0	0	G	152289598	G	G	152289598	2	3	71	1	0	0	0	0	0	0	0	1	13424	436	16	5		5	RIF1	2	152289598	Silent	SNP	A	TCGA-CN-6012-01A-11D-1683-08	2438606	152289598	90909775	14	14577											
NEB	4703	broad.mit.edu	37	chr2	152363454	152363454	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctgattttcttttacaCgcagtatttctggcgtgtct	5	20	7	9	2	5	1	0	1	5	0	5	1	5	1	0	1	1	2	0	1	2	7			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr2:152363454C>T	uc010fnx.2	-	135	18613	c.18422G>A	c.(18421-18423)CGT>CAT	p.R6141H	NEB_uc002txr.2_Missense_Mutation_p.R2564H|RIF1_uc002txp.2_Intron|NEB_uc010zca.1_5'Flank|NEB_uc010zcb.1_Translation_Start_Site|NEB_uc002txt.3_Missense_Mutation_p.R646H	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	6141	Nebulin 168.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTTTTACACGCAGTATTTC	0.318													24	54					0	0	0	0	T	152363454	T	T	152363454	3	4	71	1	0	0	0	0	1	0	0	0	10356	536	19	1	2132	1	NEB	2	152363454	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	73856	152363454	90835919	15	14578											
ALPPL2	251	broad.mit.edu	37	chr2	233274348	233274348	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagacccacgcaggcgaggaCgtggcggtgttcgcgcgcgg	6	4	19	12	8	0	1	0	0	0	1	1	4	0	2	1	5	0	2	1	5	0	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr2:233274348C>T	uc002vss.3	+	11	1418	c.1365C>T	c.(1363-1365)GAC>GAT	p.D455D		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	455					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CAGGCGAGGACGTGGCGGTGT	0.662													5	18					0	0	0	0	T	233274348	T	T	233274348	2	4	71	1	0	0	0	0	0	0	0	1	549	535	19	1		1	ALPPL2	2	233274348	Silent	SNP	C	TCGA-CN-6012-01A-11D-1683-08	80910894	233274348	9925025	16	14579											
SELK	58515	broad.mit.edu	37	chr3	53919910	53919910	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacgcagatgattgattctaCccattcttcggggagggttt	8	13	11	9	2	2	3	0	2	2	1	3	4	2	4	1	3	1	2	1	3	1	6			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:53919910C>T	uc011bet.1	-	4	398	c.224G>A	c.(223-225)GGT>GAT	p.G75D		NM_021237	NP_067060	Q9Y6D0	SELK_HUMAN	selenoprotein K	75					response to oxidative stress	endoplasmic reticulum					0				BRCA - Breast invasive adenocarcinoma(193;0.000146)|KIRC - Kidney renal clear cell carcinoma(284;0.00549)|Kidney(284;0.00619)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		ATTGATTCTACCCATTCTTCG	0.408													4	3					0	0	0	0	T	53919910	T	T	53919910	3	4	71	1	0	0	0	0	1	0	0	0	14080	507	18	4	68	4	SELK	3	53919910	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08		53919910	144102520	17	14580											
DZIP3	9666	broad.mit.edu	37	chr3	108344785	108344785	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttatgtctttagtttattttGgacgtggtttactgcgatgt	6	21	10	4	2	1	0	0	0	1	0	1	2	1	1	0	2	2	2	0	2	4	9			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:108344785G>T	uc003dxd.2	+	7	972	c.550G>T	c.(550-552)GGA>TGA	p.G184*	DZIP3_uc003dxf.1_Nonsense_Mutation_p.G184*|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Nonsense_Mutation_p.G184*	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	184					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGTTTATTTTGGACGTGGTTT	0.353													21	125					8.10497e-08	9.2102e-08	1	0	T	108344785	T	T	108344785	4	4	71	1	0	0	0	0	0	1	0	0	4887	1349	47	4	572	4	DZIP3	3	108344785	Nonsense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	54424875	108344785	89677645	18	14581											
ZDHHC23	254887	broad.mit.edu	37	chr3	113672564	113672564	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagatggattacatgtaaatCtttacagccagagacttgtg	13	13	9	6	0	1	2	0	0	1	2	1	4	1	3	1	1	3	1	1	1	5	6			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:113672564C>A	uc003eau.2	+	3	478	c.179C>A	c.(178-180)TCT>TAT	p.S60Y	ZDHHC23_uc003eav.2_Missense_Mutation_p.S54Y	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	60						integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						ACATGTAAATCTTTACAGCCA	0.403													17	72					1.45105e-14	1.76343e-14	1	0	A	113672564	A	A	113672564	3	1	71	1	0	0	0	0	1	0	0	0	17681	913	32	2	185	2	ZDHHC23	3	113672564	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	5327779	113672564	84349866	19	14582											
POLQ	10721	broad.mit.edu	37	chr3	121186390	121186390	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaaggcacaaaggcatgtcGcatgctaattgaaaatggca	16	7	11	7	1	0	1	0	1	0	0	1	2	0	1	0	3	1	5	0	3	5	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:121186390G>A	uc003eee.3	-	24	7072	c.6943C>T	c.(6943-6945)CGA>TGA	p.R2315*	POLQ_uc003eed.2_Nonsense_Mutation_p.R1487*	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2315					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AAGGCATGTCGCATGCTAATT	0.443								DNA_polymerases_(catalytic_subunits)					20	48					0	0	0	0	A	121186390	A	A	121186390	4	1	71	1	0	0	0	0	0	1	0	0	12263	1095	38	1	857	1	POLQ	3	121186390	Nonsense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	7513826	121186390	76836040	20	14583											
ADCY5	111	broad.mit.edu	37	chr3	123003507	123003507	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggtcatcatctcgcctttgCccttgaccttgaccacgccc	6	11	7	17	2	3	2	2	2	1	0	4	2	3	2	5	1	1	0	5	1	0	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:123003507C>T	uc003egh.1	-	21	3734	c.3734G>A	c.(3733-3735)GGC>GAC	p.G1245D	ADCY5_uc003egg.1_Missense_Mutation_p.G903D	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	1245	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		CTCGCCTTTGCCCTTGACCTT	0.612													5	288					0	0	0	0	T	123003507	T	T	123003507	3	4	71	1	0	0	0	0	1	0	0	0	297	739	26	4	55	4	ADCY5	3	123003507	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	1817117	123003507	75018923	21	14584											
ABTB1	80325	broad.mit.edu	37	chr3	127395182	127395182	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaagccattccgggtgcatCgctgcgtcctgggtgcacgt	5	9	15	12	4	0	0	0	0	0	0	3	1	2	1	3	3	4	3	3	3	1	1	rs149260862		TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:127395182C>T	uc003ejt.2	+	5	476	c.388C>T	c.(388-390)CGC>TGC	p.R130C	ABTB1_uc003ejr.2_5'UTR|ABTB1_uc003ejs.2_Missense_Mutation_p.R105C|ABTB1_uc003eju.2_5'UTR|ABTB1_uc010hsm.2_5'Flank	NM_172027	NP_742024	Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	130	BTB 1.					cytoplasm|nucleolus|plasma membrane	translation elongation factor activity				0						CCGGGTGCATCGCTGCGTCCT	0.572													22	138					0	0	0	0	T	127395182	T	T	127395182	3	4	71	1	0	0	0	0	1	0	0	0	102	884	31	1	406	1	ABTB1	3	127395182	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	4391675	127395182	70627248	22	14585											
COL6A6	131873	broad.mit.edu	37	chr3	130380658	130380658	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcaccccagagccggagaCttctgtcactggagaccggg	10	6	12	13	2	3	3	2	0	1	3	3	5	3	3	4	3	1	0	4	3	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:130380658C>T	uc010htl.2	+	34	6039	c.6008C>T	c.(6007-6009)ACT>ATT	p.T2003I	COL6A6_uc003eni.3_Missense_Mutation_p.T102I	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	2003	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GAGCCGGAGACTTCTGTCACT	0.517													10	38					0	0	0	0	T	130380658	T	T	130380658	3	4	71	1	0	0	0	0	1	0	0	0	3718	565	20	4	6142	4	COL6A6	3	130380658	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	2985476	130380658	67641772	23	14586											
HPS3	84343	broad.mit.edu	37	chr3	148880100	148880100	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaacaaaattggaattgaaGaagcagattccttttttaag	17	12	7	5	0	0	3	0	1	0	2	1	4	1	4	1	1	2	1	1	1	7	6			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:148880100G>C	uc003ewu.1	+	12	2412	c.2272G>C	c.(2272-2274)GAA>CAA	p.E758Q	HPS3_uc011bnq.1_Missense_Mutation_p.E593Q|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	758						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TGGAATTGAAGAAGCAGATTC	0.423									Hermansky-Pudlak_syndrome				7	89					0	0	0	0	C	148880100	C	C	148880100	3	2	71	1	0	0	0	0	1	0	0	0	7379	943	33	2	2318	2	HPS3	3	148880100	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	18499442	148880100	49142330	24	14587											
SHOX2	6474	broad.mit.edu	37	chr3	157820503	157820503	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaggcccagtcgctggctCagttcctctcgcatgaaggc	7	8	12	14	2	2	1	1	1	1	0	5	2	3	1	2	3	0	4	2	3	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:157820503C>T	uc003fbr.2	-	2	658	c.519G>A	c.(517-519)CTG>CTA	p.L173L	SHOX2_uc003fbs.2_Silent_p.L197L|SHOX2_uc010hvw.2_Silent_p.L173L	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	173	Homeobox.				nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			GTCGCTGGCTCAGTTCCTCTC	0.607													6	94					0	0	0	0	T	157820503	T	T	157820503	2	4	71	1	0	0	0	0	0	0	0	1	14354	813	29	2		2	SHOX2	3	157820503	Silent	SNP	C	TCGA-CN-6012-01A-11D-1683-08	8940403	157820503	40201927	25	14588											
MAGEF1	64110	broad.mit.edu	37	chr3	184429482	184429482	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagccccctcctccctcccgGcgccaagctcctccttgggg	3	7	9	22	2	0	0	0	0	0	0	5	0	5	0	8	3	2	1	8	3	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:184429482G>A	uc003fpa.2	-	1	355	c.128C>T	c.(127-129)GCC>GTC	p.A43V		NM_022149	NP_071432	Q9HAY2	MAGF1_HUMAN	melanoma antigen family F, 1	43										ovary(1)	1	all_cancers(143;4.61e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;5.64e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.56e-22)			CTCCCTCCCGGCGCCAAGCTC	0.751													7	49					0	0	0	0	A	184429482	A	A	184429482	3	1	71	1	0	0	0	0	1	0	0	0	9240	1203	42	4	799	4	MAGEF1	3	184429482	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	26608979	184429482	13592948	26	14589											
UBXN7	26043	broad.mit.edu	37	chr3	196089387	196089387	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctacctcttcttcttcatCagagccacaaacggatatga	11	12	5	13	1	6	2	2	1	4	1	6	3	6	3	2	1	3	0	2	1	3	5			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:196089387C>T	uc003fwm.3	-	9	1081	c.1006G>A	c.(1006-1008)GAT>AAT	p.D336N	UBXN7_uc003fwn.3_Missense_Mutation_p.D188N|UBXN7_uc010iae.2_Missense_Mutation_p.D174N	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	336							protein binding			ovary(2)|pancreas(1)	3						TCTTCTTCATCAGAGCCACAA	0.443													19	148					0	0	0	0	T	196089387	T	T	196089387	3	4	71	1	0	0	0	0	1	0	0	0	16986	826	29	2	475	2	UBXN7	3	196089387	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	11659905	196089387	1933043	27	14590											
DHX15	1665	broad.mit.edu	37	chr4	24529592	24529592	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgaagtttggcaatgatgcgGtccaactgtctctttgcttc	7	15	10	9	1	1	2	0	2	1	0	4	2	2	2	1	2	3	3	1	2	3	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr4:24529592G>A	uc003gqx.2	-	14	2511	c.2343C>T	c.(2341-2343)GAC>GAT	p.D781D	DHX15_uc003gqv.2_Silent_p.D187D|DHX15_uc003gqw.2_Silent_p.D204D	NM_001358	NP_001349	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 15	781					mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(1)	1		Breast(46;0.0503)				CAATGATGCGGTCCAACTGTC	0.393													15	23					0	0	0	0	A	24529592	A	A	24529592	2	1	71	1	0	0	0	0	0	0	0	1	4523	1252	44	4		4	DHX15	4	24529592	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08		24529592	166624684	28	14591											
ADAMTS3	9508	broad.mit.edu	37	chr4	73156643	73156643	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggccggcggctctcgggacGgtcacccatgcagtatttgc	5	8	15	13	4	2	0	1	0	1	0	3	1	2	1	2	5	2	3	2	5	1	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr4:73156643G>T	uc003hgk.1	-	20	2897	c.2860C>A	c.(2860-2862)CGT>AGT	p.R954S		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	954	TSP type-1 3.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTCTCGGGACGGTCACCCATG	0.572													23	24					1.55795e-14	1.88028e-14	1	0	T	73156643	T	T	73156643	3	4	71	1	0	0	0	0	1	0	0	0	267	1116	39	3	769	3	ADAMTS3	4	73156643	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	48627051	73156643	117997633	29	14592											
FAT1	2195	broad.mit.edu	37	chr4	187539227	187539227	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taacttggccgttggttcctGagtcagcatcagatgccctg	7	12	11	11	1	2	2	2	1	0	1	3	2	3	2	3	2	3	3	3	2	1	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr4:187539227G>T	uc003izf.2	-	10	8701	c.8513C>A	c.(8512-8514)TCA>TAA	p.S2838*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2838	Extracellular (Potential).|Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTTGGTTCCTGAGTCAGCATC	0.448										HNSCC(5;0.00058)			26	33					1.38267e-23	1.74077e-23	1	0	T	187539227	T	T	187539227	4	4	71	1	0	0	0	0	0	1	0	0	5721	1294	45	2	5325	2	FAT1	4	187539227	Nonsense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	114382584	187539227	3615049	30	14593											
SLC9A3	6550	broad.mit.edu	37	chr5	484690	484690	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtaggacaggtaggagaTgatgaacacgaagccgggct	13	5	16	7	2	0	3	0	2	0	1	0	6	0	4	1	5	2	3	1	5	4	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:484690T>C	uc003jbe.2	-	5	989	c.877A>G	c.(877-879)ATC>GTC	p.I293V	SLC9A3_uc011clx.1_Missense_Mutation_p.I293V	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	293	Helical; Name=I/M7; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AGGTAGGAGATGATGAACACG	0.642													7	45					0	0	0	0	C	484690	C	C	484690	3	2	71	1	0	0	0	0	1	0	0	0	14777	1464	51	5	1679	5	SLC9A3	5	484690	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08		484690	180430570	31	14594											
IRX1	79192	broad.mit.edu	37	chr5	3599777	3599777	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatcgacgagcacgatggcGaccagagcaacgaggatgac	14	3	14	10	5	0	3	0	1	0	2	1	9	0	4	1	2	3	2	1	2	1	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:3599777G>T	uc003jde.2	+	2	767	c.715G>T	c.(715-717)GAC>TAC	p.D239Y		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	239						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GCACGATGGCGACCAGAGCAA	0.662													13	28					6.31663e-08	7.2249e-08	1	0	T	3599777	T	T	3599777	3	4	71	1	0	0	0	0	1	0	0	0	7882	1058	37	3	721	3	IRX1	5	3599777	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	3115087	3599777	177315483	32	14595											
CDH18	1016	broad.mit.edu	37	chr5	19483429	19483429	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaggagaatgagaacacaGagaagaatagcgattaaggc	18	4	12	7	1	0	4	0	1	0	4	0	8	0	4	1	2	2	0	1	2	6	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:19483429G>A	uc003jgc.2	-	11	2240	c.1863C>T	c.(1861-1863)CTC>CTT	p.L621L	CDH18_uc003jgd.2_Silent_p.L621L|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	621	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TGAGAACACAGAGAAGAATAG	0.463													11	21					0	0	0	0	A	19483429	A	A	19483429	2	1	71	1	0	0	0	0	0	0	0	1	3118	929	33	2		2	CDH18	5	19483429	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	15883652	19483429	161431831	33	14596											
PRDM9	56979	broad.mit.edu	37	chr5	23510095	23510095	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcaaactccaggtggatgAcacagaagattctgatgaag	15	8	10	8	0	2	5	1	3	1	2	3	6	3	6	1	2	1	0	1	2	3	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:23510095A>G	uc003jgo.2	+	4	442	c.260A>G	c.(259-261)GAC>GGC	p.D87G		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	87					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CAGGTGGATGACACAGAAGAT	0.383										HNSCC(3;0.000094)			7	37					0	0	0	0	G	23510095	G	G	23510095	3	3	71	1	0	0	0	0	1	0	0	0	12525	275	10	5	270	5	PRDM9	5	23510095	Missense_Mutation	SNP	A	TCGA-CN-6012-01A-11D-1683-08	4026666	23510095	157405165	34	14597											
CDH10	1008	broad.mit.edu	37	chr5	24537631	24537631	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctgttaatagcttgtgcGcgtagagtataaaaggcctt	10	14	10	7	2	1	1	0	0	1	1	1	1	1	1	1	1	2	4	1	1	6	8			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:24537631G>A	uc003jgr.1	-	3	716	c.384C>T	c.(382-384)CGC>CGT	p.R128R	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	128	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TAGCTTGTGCGCGTAGAGTAT	0.413										HNSCC(23;0.051)			28	59					0	0	0	0	A	24537631	A	A	24537631	2	1	71	1	0	0	0	0	0	0	0	1	3111	1074	38	1		1	CDH10	5	24537631	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	1027536	24537631	156377629	35	14598											
MRPS30	10884	broad.mit.edu	37	chr5	44811123	44811123	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgatagattatagatgccCagttcatttttactgggtgc	9	17	9	6	0	1	3	1	1	0	2	1	3	1	3	1	1	3	1	1	1	4	8			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:44811123C>T	uc003joh.2	+	2	652	c.614C>T	c.(613-615)CCA>CTA	p.P205L	MRPS30_uc003joi.1_RNA	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	205					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					TATAGATGCCCAGTTCATTTT	0.333													4	48					0	0	0	0	T	44811123	T	T	44811123	3	4	71	1	0	0	0	0	1	0	0	0	9893	594	21	4	620	4	MRPS30	5	44811123	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	20273492	44811123	136104137	36	14599											
PRR16	51334	broad.mit.edu	37	chr5	120021745	120021745	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgctgaatagtagctcaagtGgcacaacagcctccagccta	12	7	9	13	1	1	1	1	1	0	0	2	1	2	1	3	1	4	4	3	1	6	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:120021745G>T	uc003ksq.2	+	2	419	c.256G>T	c.(256-258)GGC>TGC	p.G86C	PRR16_uc003ksp.2_Missense_Mutation_p.G63C|PRR16_uc003ksr.2_Missense_Mutation_p.G16C	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	86										pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		TAGCTCAAGTGGCACAACAGC	0.522													5	36					1.23904e-05	1.3811e-05	1	0	T	120021745	T	T	120021745	3	4	71	1	0	0	0	0	1	0	0	0	12651	1348	47	4	193	4	PRR16	5	120021745	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	75210622	120021745	60893515	37	14600											
PCDHAC1	56135	broad.mit.edu	37	chr5	140307589	140307589	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaggatgaagacctcgattCtaatggtagggtcatttgtg	12	12	12	5	1	2	2	1	1	1	1	3	4	2	3	1	3	0	1	1	3	4	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:140307589C>G	uc003lih.2	+	1	1288	c.1112C>G	c.(1111-1113)TCT>TGT	p.S371C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.S371C	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	371	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCTCGATTCTAATGGTAGG	0.522													15	22					0	0	0	0	G	140307589	G	G	140307589	3	3	71	1	0	0	0	0	1	0	0	0	11586	913	32	2	1114	2	PCDHAC1	5	140307589	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	20285844	140307589	40607671	38	14601											
GRIA1	2890	broad.mit.edu	37	chr5	153026599	153026599	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacgtctgcttcattacgcCgagctttcccgttgatacat	7	13	7	14	4	2	1	1	1	1	0	3	2	3	1	3	0	4	3	3	0	2	5			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:153026599C>T	uc003lva.3	+	3	697	c.332C>T	c.(331-333)CCG>CTG	p.P111L	GRIA1_uc003luy.3_Missense_Mutation_p.P111L|GRIA1_uc003luz.3_Missense_Mutation_p.P16L|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Missense_Mutation_p.P42L|GRIA1_uc011dcy.1_Missense_Mutation_p.P121L|GRIA1_uc011dcz.1_Missense_Mutation_p.P121L|GRIA1_uc010jia.1_Missense_Mutation_p.P91L	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	111	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TTCATTACGCCGAGCTTTCCC	0.493													6	72					0	0	0	0	T	153026599	T	T	153026599	3	4	71	1	0	0	0	0	1	0	0	0	6806	652	23	1	342	1	GRIA1	5	153026599	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	12719010	153026599	27888661	39	14602											
CAGE1	285782	broad.mit.edu	37	chr6	7370283	7370283	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccgggagcagattagaatGtgtcgtttttgtatcctaca	10	14	10	7	2	0	2	0	0	0	2	3	3	2	3	2	1	2	3	2	1	4	5			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:7370283G>A	uc003mxi.2	-	5	2075	c.1354C>T	c.(1354-1356)CAT>TAT	p.H452Y	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Missense_Mutation_p.H343Y|CAGE1_uc003mxk.1_Missense_Mutation_p.H343Y	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	588											0	Ovarian(93;0.0418)					AGATTAGAATGTGTCGTTTTT	0.383													5	25					0	0	0	0	A	7370283	A	A	7370283	3	1	71	1	0	0	0	0	1	0	0	0	2584	1377	48	4	899	4	CAGE1	6	7370283	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08		7370283	163744784	40	14603											
HIST1H1C	3006	broad.mit.edu	37	chr6	26056533	26056533	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagccttggtgatgagctCtgacaccgggggaccagacg	9	6	14	12	2	1	4	0	3	1	1	1	5	1	5	3	3	2	1	3	3	0	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:26056533C>G	uc003nfw.2	-	1	167	c.124G>C	c.(124-126)GAG>CAG	p.E42Q		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	42	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GTGATGAGCTCTGACACCGGG	0.612													10	90					0	0	0	0	G	26056533	G	G	26056533	3	3	71	1	0	0	0	0	1	0	0	0	7163	922	32	2	521	2	HIST1H1C	6	26056533	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	18686250	26056533	145058534	41	14604											
OR5V1	81696	broad.mit.edu	37	chr6	29323824	29323824	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgcaggtgtggatcagtcAcagtcgtcaagataattaat	13	12	10	6	1	3	1	3	0	0	1	4	2	3	2	0	2	1	1	0	2	4	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:29323824A>G	uc011dlo.1	-	1	231	c.149T>C	c.(148-150)GTG>GCG	p.V50A		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						TGGATCAGTCACAGTCGTCAA	0.388													20	125					0	0	0	0	G	29323824	G	G	29323824	3	3	71	1	0	0	0	0	1	0	0	0	11238	159	6	5	819	5	OR5V1	6	29323824	Missense_Mutation	SNP	A	TCGA-CN-6012-01A-11D-1683-08	3267291	29323824	141791243	42	14605											
NOTCH4	4855	broad.mit.edu	37	chr6	32171962	32171962	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaggcattggccagagagtGgcaggctgcagtgcctgtgg	8	7	18	8	0	0	1	0	0	0	1	0	3	0	1	2	5	2	4	2	5	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:32171962G>T	uc003obb.2	-	19	3209	c.3070C>A	c.(3070-3072)CAC>AAC	p.H1024N	NOTCH4_uc003oba.2_5'Flank|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1024	Extracellular (Potential).|EGF-like 26.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GCCAGAGAGTGGCAGGCTGCA	0.627													4	25					0.00024832	0.000268247	1	0	T	32171962	T	T	32171962	3	4	71	1	0	0	0	0	1	0	0	0	10605	1348	47	4	2989	4	NOTCH4	6	32171962	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	2848138	32171962	138943105	43	14606											
TRERF1	55809	broad.mit.edu	37	chr6	42231078	42231078	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcacaggcatctcgtcgtCcgacatcgagctggctggct	7	8	13	13	4	1	0	0	0	1	0	5	3	2	0	1	3	2	5	1	3	0	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:42231078C>A	uc003osd.2	-	8	2427	c.1864G>T	c.(1864-1866)GAC>TAC	p.D622Y	TRERF1_uc011duq.1_Intron|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Missense_Mutation_p.D622Y	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	622	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ATCTCGTCGTCCGACATCGAG	0.667													8	79					0.000274275	0.000294467	1	0	A	42231078	A	A	42231078	3	1	71	1	0	0	0	0	1	0	0	0	16542	855	30	2	1782	2	TRERF1	6	42231078	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	10059116	42231078	128883989	44	14607											
CNR1	1268	broad.mit.edu	37	chr6	88854382	88854382	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtgaggaacaggctgccCacggaggcagtgaaggaggc	10	4	18	9	1	0	2	0	2	0	0	0	5	0	5	1	6	2	3	1	6	2	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:88854382C>T	uc011dzq.1	-	2	4175	c.612G>A	c.(610-612)GTG>GTA	p.V204V	CNR1_uc010kbz.2_Silent_p.V204V|CNR1_uc011dzr.1_Silent_p.V204V|CNR1_uc011dzs.1_Silent_p.V204V|CNR1_uc003pmq.3_Silent_p.V204V|CNR1_uc011dzt.1_Silent_p.V204V|CNR1_uc010kca.2_Silent_p.V171V	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	204	Helical; Name=3; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	ACAGGCTGCCCACGGAGGCAG	0.557													3	30					0	0	0	0	T	88854382	T	T	88854382	2	4	71	1	0	0	0	0	0	0	0	1	3646	581	21	4		4	CNR1	6	88854382	Silent	SNP	C	TCGA-CN-6012-01A-11D-1683-08	46623304	88854382	82260685	45	14608											
C6orf97	80129	broad.mit.edu	37	chr6	151859254	151859254	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagctgaaatggagagctaCaaggaaaacaatgccagaaa	21	4	10	6	0	0	3	0	1	0	2	0	5	0	4	1	2	5	2	1	2	8	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:151859254C>G	uc003qol.2	+	3	350	c.261C>G	c.(259-261)TAC>TAG	p.Y87*		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	87	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		TGGAGAGCTACAAGGAAAACA	0.388													7	46					0	0	0	0	G	151859254	G	G	151859254	4	3	71	1	0	0	0	0	0	1	0	0	2385	489	17	4	271	4	C6orf97	6	151859254	Nonsense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	63004872	151859254	19255813	46	14609											
C6orf97	80129	broad.mit.edu	37	chr6	151936746	151936746	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagggccagaaacatgataGaagtggtaaccagtgaaatg	18	6	12	5	0	0	4	0	2	0	2	0	4	0	4	2	2	2	1	2	2	6	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:151936746G>T	uc003qol.2	+	10	1968	c.1879G>T	c.(1879-1881)GAA>TAA	p.E627*		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	627	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		AAACATGATAGAAGTGGTAAC	0.403													37	82					2.87052e-16	3.53761e-16	1	0	T	151936746	T	T	151936746	4	4	71	1	0	0	0	0	0	1	0	0	2385	943	33	2	1917	2	C6orf97	6	151936746	Nonsense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	77492	151936746	19178321	47	14610											
GPNMB	10457	broad.mit.edu	37	chr7	23286502	23286502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgtctctactatttcctggGatttctgctcctggctgcaa	6	16	8	11	0	2	0	0	0	2	0	5	1	4	1	2	2	3	3	2	2	3	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr7:23286502G>A	uc003swc.2	+	1	187	c.26G>A	c.(25-27)GGA>GAA	p.G9E	GPNMB_uc003swa.2_Missense_Mutation_p.G9E|GPNMB_uc003swb.2_Missense_Mutation_p.G9E|GPNMB_uc011jyy.1_Missense_Mutation_p.G9E|GPNMB_uc011jyz.1_Missense_Mutation_p.G9E	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	9					negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			TATTTCCTGGGATTTCTGCTC	0.478													28	51					0	0	0	0	A	23286502	A	A	23286502	3	1	71	1	0	0	0	0	1	0	0	0	6658	1174	41	2	28	2	GPNMB	7	23286502	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08		23286502	135852161	48	14611											
HOXA7	3204	broad.mit.edu	37	chr7	27194647	27194647	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcggcggcagtcggaccttCgtccttatgctctttcttcc	3	14	10	14	4	2	0	0	0	2	0	6	1	4	1	3	3	2	2	3	3	1	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr7:27194647C>T	uc003sys.2	-	2	706	c.574G>A	c.(574-576)GAA>AAA	p.E192K	HOXA6_uc003syq.1_5'Flank|uc003syr.1_3'UTR	NM_006896	NP_008827	P31268	HXA7_HUMAN	homeobox A7	192					angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding				0						GTCGGACCTTCGTCCTTATGC	0.537													11	120					0	0	0	0	T	27194647	T	T	27194647	3	4	71	1	0	0	0	0	1	0	0	0	7336	893	31	1	122	1	HOXA7	7	27194647	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	3908145	27194647	131944016	49	14612											
SRRT	51593	broad.mit.edu	37	chr7	100473251	100473274	+	In_Frame_Del	DEL	GACAAGTTCAGAAGAGAGCGCAGC	-	-																															agtacgatcgaaggcgcaggGacaagttcagaagagagcgc																										TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr7:100473251_100473274delGACAAGTTCAGAAGAGAGCGCAGC	uc003uwy.2	+	3	308_331	c.40_63delGACAAGTTCAGAAGAGAGCGCAGC	c.(40-63)GACAAGTTCAGAAGAGAGCGCAGCdel	p.DKFRRERS14del	SRRT_uc010lhl.1_In_Frame_Del_p.DKFRRERS14del|SRRT_uc003uxa.2_In_Frame_Del_p.DKFRRERS14del|SRRT_uc003uwz.2_In_Frame_Del_p.DKFRRERS14del	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	14_21	Arg-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						AAGGCGCAGGGACAAGTTCAGAAGAGAGCGCAGCGACTACGACC	0.58													---	---	---								-	100473274	-	-	100473251	7	5	71	1	0	1	0	1	0	0	0	0	15238	1174	41	0	42	0	SRRT	7	100473251	In_Frame_Del	DEL	GACAAGTTCAGAAGAGAGCGCAGC	TCGA-CN-6012-01A-11D-1683-08	73278604	100473251	58665412	50	14613											
RNF148	378925	broad.mit.edu	37	chr7	122341901	122341901	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttcttaagttttcaggaTgtcacacttgcacatgggac	10	14	9	8	0	3	0	2	0	1	0	3	3	3	2	0	2	1	2	0	2	1	5			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr7:122341901T>C	uc003vkk.1	-	1	1121	c.904A>G	c.(904-906)ATC>GTC	p.I302V	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron|RNF133_uc003vkj.1_5'Flank|RNF148_uc010lkr.1_3'UTR	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	ring finger protein 148 precursor	302						integral to membrane	zinc ion binding				0						GTTTTCAGGATGTCACACTTG	0.358													7	106					0	0	0	0	C	122341901	C	C	122341901	3	2	71	1	0	0	0	0	1	0	0	0	13514	1464	51	5	17	5	RNF148	7	122341901	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08	21868650	122341901	36796762	51	14614											
FLNC	2318	broad.mit.edu	37	chr7	128489488	128489488	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatgcacggtgtccacgccGgatggggcagagctcgatgt	8	7	15	11	4	0	1	0	0	0	1	2	3	1	2	2	4	2	3	2	4	0	0	rs57797061	by1000genomes	TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr7:128489488G>A	uc003vnz.3	+	30	5264	c.5055G>A	c.(5053-5055)CCG>CCA	p.P1685P	FLNC_uc003voa.3_Silent_p.P1685P	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1685	Filamin 15.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TGTCCACGCCGGATGGGGCAG	0.607													3	53					0	0	0	0	A	128489488	A	A	128489488	2	1	71	1	0	0	0	0	0	0	0	1	5967	1103	39	1		1	FLNC	7	128489488	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	6147587	128489488	30649175	52	14615											
COPS5	10987	broad.mit.edu	37	chr8	67958147	67958147	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctgggcttctgactgctCtaacttttcagacaaatcaa	11	12	7	11	0	4	2	2	1	2	1	4	2	4	2	0	1	3	3	0	1	3	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr8:67958147C>G	uc003xxe.2	-	7	1151	c.820G>C	c.(820-822)GAG>CAG	p.E274Q	COPS5_uc003xxd.2_Missense_Mutation_p.E210Q|COPS5_uc003xxf.2_Missense_Mutation_p.E319Q|COPS5_uc010lyu.1_RNA	NM_006837	NP_006828	Q92905	CSN5_HUMAN	COP9 signalosome subunit 5	274					cullin deneddylation|transcription from RNA polymerase II promoter	eukaryotic translation initiation factor 3 complex|signalosome	metal ion binding|metallopeptidase activity|protein binding|transcription coactivator activity|translation initiation factor activity			ovary(1)|skin(1)	2	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00389)|OV - Ovarian serous cystadenocarcinoma(28;0.00691)|all cancers(69;0.0205)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TCTGACTGCTCTAACTTTTCA	0.438													6	89					0	0	0	0	G	67958147	G	G	67958147	3	3	71	1	0	0	0	0	1	0	0	0	3751	922	32	2	192	2	COPS5	8	67958147	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08		67958147	78405875	53	14616											
SLCO5A1	81796	broad.mit.edu	37	chr8	70744677	70744677	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agagggactgggggccaacgGgttcgggccttgcttcaact	7	8	16	10	2	1	1	1	0	0	1	2	2	1	2	2	5	3	2	2	5	2	3	rs146746403		TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr8:70744677G>C	uc003xyl.2	-	2	939	c.232C>G	c.(232-234)CCG>GCG	p.P78A	SLCO5A1_uc010lzb.2_Missense_Mutation_p.P78A|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.P78A|SLCO5A1_uc010lzc.2_Missense_Mutation_p.P78A	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	78	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GGGGCCAACGGGTTCGGGCCT	0.647											OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	43					0	0	0	0	C	70744677	C	C	70744677	3	2	71	1	0	0	0	0	1	0	0	0	14795	1232	43	4	2350	4	SLCO5A1	8	70744677	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	2786530	70744677	75619345	54	14617											
CTHRC1	115908	broad.mit.edu	37	chr8	104394752	104394752	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatctgggttggtacttgttCagattacccaaaaggagatg	11	13	11	6	0	2	2	1	0	1	2	2	3	2	2	1	3	2	3	1	3	5	6			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr8:104394752C>G	uc003ylk.2	+	4	755	c.656C>G	c.(655-657)TCA>TGA	p.S219*		NM_138455	NP_612464	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	219						collagen				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			GGTACTTGTTCAGATTACCCA	0.373													13	158					0	0	0	0	G	104394752	G	G	104394752	4	3	71	1	0	0	0	0	0	1	0	0	4027	838	29	2	670	2	CTHRC1	8	104394752	Nonsense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	33650075	104394752	41969270	55	14618											
RECQL4	9401	broad.mit.edu	37	chr8	145740836	145740836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacagcatctgtgtcttcctCacttgctggggcaggcagga	8	10	12	11	0	3	0	1	0	2	0	4	1	4	1	1	4	3	4	1	4	1	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr8:145740836C>T	uc003zdj.2	-	7	1296	c.1264G>A	c.(1264-1266)GAG>AAG	p.E422K	LRRC14_uc003zdk.1_5'Flank|LRRC14_uc003zdl.1_5'Flank	NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	422					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GTGTCTTCCTCACTTGCTGGG	0.612			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				7	85					0	0	0	0	T	145740836	T	T	145740836	3	4	71	1	0	0	0	0	1	0	0	0	13267	835	29	2	2423	2	RECQL4	8	145740836	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	41346084	145740836	623186	56	14619											
CDKN2A	1029	broad.mit.edu	37	chr9	21971096	21971096	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcgtgtccaggaagccctCccgggcagcgtcgtgcacgg	6	5	15	15	5	0	0	0	0	0	0	3	1	2	1	3	3	4	2	3	3	1	0	rs121913384		TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr9:21971096C>A	uc003zpk.2	-	2	474	c.262G>T	c.(262-264)GAG>TAG	p.E88*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.G143V	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	88	ANK 3.		E -> D (in a biliary tract tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E88*(13)|p.E88E(6)|p.E88K(3)|p.H83fs*2(2)|p.E88D(2)|p.E88A(1)|p.E88G(1)|p.D84_F90del(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.E88V(1)|p.E87K(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		AGGAAGCCCTCCCGGGCAGCG	0.756	E88*(CAL33_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	11					8.12818e-05	8.94611e-05	1	0	A	21971096	A	A	21971096	4	1	71	1	0	0	0	0	0	1	0	0	3176	864	30	2	216	2	CDKN2A	9	21971096	Nonsense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08		21971096	119242335	57	14620											
PRUNE2	158471	broad.mit.edu	37	chr9	79324742	79324742	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgcttgttgggtgcaaattCcaggtattttttaaagcttc	8	17	9	7	0	0	0	0	0	0	0	2	0	1	0	1	2	3	5	1	2	4	8			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr9:79324742C>T	uc010mpk.2	-	8	2572	c.2448G>A	c.(2446-2448)TGG>TGA	p.W816*		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	816					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GGTGCAAATTCCAGGTATTTT	0.468													8	29					0	0	0	0	T	79324742	T	T	79324742	4	4	71	1	0	0	0	0	0	1	0	0	12703	856	30	2	6866	2	PRUNE2	9	79324742	Nonsense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	57353646	79324742	61888689	58	14621											
C9orf79	286234	broad.mit.edu	37	chr9	90502130	90502130	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caggagacaacagaacaacaAgcaagtcagtcccgaccgtg	16	3	10	12	2	1	2	1	0	0	2	2	4	2	2	2	1	4	1	2	1	5	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr9:90502130A>G	uc004app.3	+	4	2763	c.2728A>G	c.(2728-2730)AGC>GGC	p.S910G	C9orf79_uc004apo.1_Missense_Mutation_p.S722G	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	910						integral to membrane				ovary(3)	3						CAGAACAACAAGCAAGTCAGT	0.602													4	49					0	0	0	0	G	90502130	G	G	90502130	3	3	71	1	0	0	0	0	1	0	0	0	2509	72	3	5	2742	5	C9orf79	9	90502130	Missense_Mutation	SNP	A	TCGA-CN-6012-01A-11D-1683-08	11177388	90502130	50711301	59	14622											
PTCH1	5727	broad.mit.edu	37	chr9	98239831	98239831	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatggctcctttagtacctGagttgttgcagcgttaaagg	10	13	11	7	1	0	1	0	1	0	0	1	1	1	1	2	2	3	6	2	2	5	6			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr9:98239831G>C	uc004avk.3	-	10	1689	c.1501C>G	c.(1501-1503)CAG>GAG	p.Q501E	PTCH1_uc010mro.2_Missense_Mutation_p.Q350E|PTCH1_uc010mrp.2_Missense_Mutation_p.Q350E|PTCH1_uc010mrq.2_Missense_Mutation_p.Q350E|PTCH1_uc004avl.3_Missense_Mutation_p.Q350E|PTCH1_uc010mrr.2_Missense_Mutation_p.Q435E|PTCH1_uc004avm.3_Missense_Mutation_p.Q500E|PTCH1_uc010mrs.1_Intron	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	501	Extracellular (Potential).|SSD.				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TTTAGTACCTGAGTTGTTGCA	0.582									Basal_Cell_Nevus_syndrome				6	35					0	0	0	0	C	98239831	C	C	98239831	3	2	71	1	0	0	0	0	1	0	0	0	12792	1299	45	2	2898	2	PTCH1	9	98239831	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	7737701	98239831	42973600	60	14623											
DIP2C	22982	broad.mit.edu	37	chr10	445090	445090	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatgggcacggggaccacctCggccagcaggcagccgtaga	9	3	16	13	3	0	1	0	0	0	1	1	3	0	2	4	5	2	4	4	5	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:445090C>T	uc001ifp.2	-	10	1309	c.1219G>A	c.(1219-1221)GAG>AAG	p.E407K	DIP2C_uc009xhj.1_Missense_Mutation_p.E103K	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	407						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGGACCACCTCGGCCAGCAGG	0.617													5	33					0	0	0	0	T	445090	T	T	445090	3	4	71	1	0	0	0	0	1	0	0	0	4551	893	31	1	3563	1	DIP2C	10	445090	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08		445090	135089657	61	14624											
ITGA8	8516	broad.mit.edu	37	chr10	15649678	15649678	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctttctggaatacttactcGaaggtaaacgatgaaatcct	13	13	7	8	2	2	1	0	1	2	0	4	4	3	2	1	2	3	1	1	2	7	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:15649678G>A	uc001ioc.1	-	17	1762	c.1762C>T	c.(1762-1764)CGA>TGA	p.R588*	ITGA8_uc010qcb.1_Nonsense_Mutation_p.R573*	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	588	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						ATACTTACTCGAAGGTAAACG	0.448													24	222					0	0	0	0	A	15649678	A	A	15649678	4	1	71	1	0	0	0	0	0	1	0	0	7921	1066	37	1	1485	1	ITGA8	10	15649678	Nonsense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	15204588	15649678	119885069	62	14625											
CUBN	8029	broad.mit.edu	37	chr10	16882891	16882891	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctatttactcactgtccatGatggtgtatgtagcattaaa	11	16	7	7	0	2	1	1	1	1	0	3	1	3	1	1	1	2	3	1	1	6	6			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:16882891G>A	uc001ioo.2	-	61	9871	c.9819C>T	c.(9817-9819)ATC>ATT	p.I3273I		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3273	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CACTGTCCATGATGGTGTATG	0.343													8	41					0	0	0	0	A	16882891	A	A	16882891	2	1	71	1	0	0	0	0	0	0	0	1	4068	1280	45	2		2	CUBN	10	16882891	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	1233213	16882891	118651856	63	14626											
MRC1	4360	broad.mit.edu	37	chr10	17905662	17905662	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaccatcgaggaagaggttCggttcacccactggaattca	11	8	12	10	2	2	1	2	0	0	1	4	5	2	4	2	5	0	2	2	5	2	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:17905662C>T	uc001ipk.2	+	11	1856	c.1753C>T	c.(1753-1755)CGG>TGG	p.R585W		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	585	C-type lectin 3.|Extracellular (Potential).				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						GGAAGAGGTTCGGTTCACCCA	0.448													34	59					0	0	0	0	T	17905662	T	T	17905662	3	4	71	1	0	0	0	0	1	0	0	0	9809	875	31	1	1795	1	MRC1	10	17905662	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	1022771	17905662	117629085	64	14627											
ZNF485	220992	broad.mit.edu	37	chr10	44112550	44112550	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actcacagtggaaataaaccGtatcagtgtcgtgactgtgg	12	10	11	8	2	2	1	2	1	0	0	3	2	2	2	1	2	1	1	1	2	4	2	rs141606024	byFrequency	TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:44112550G>A	uc010qfc.1	+	5	1253	c.1059G>A	c.(1057-1059)CCG>CCA	p.P353P	ZNF485_uc010qfd.1_Silent_p.P262P	NM_145312	NP_660355	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAATAAACCGTATCAGTGTC	0.418													4	80					0	0	0	0	A	44112550	A	A	44112550	2	1	71	1	0	0	0	0	0	0	0	1	18005	1132	40	1		1	ZNF485	10	44112550	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	26206888	44112550	91422197	65	14628											
CXCL12	6387	broad.mit.edu	37	chr10	44876302	44876302	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgaagaatcggcatgggcAtctgtagctcaggctgacgg	9	9	14	9	3	2	2	1	1	1	1	4	3	2	2	0	4	1	5	0	4	3	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:44876302A>G	uc001jbf.2	-	2	177	c.88T>C	c.(88-90)TGC>CGC	p.C30R	CXCL12_uc001jbh.2_Missense_Mutation_p.C30R|CXCL12_uc001jbi.2_Missense_Mutation_p.C30R	NM_000609	NP_000600	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12 (stromal	30					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity				0					Dexamethasone(DB01234)	CGGCATGGGCATCTGTAGCTC	0.493													18	136					0	0	0	0	G	44876302	G	G	44876302	3	3	71	1	0	0	0	0	1	0	0	0	4097	217	8	5	468	5	CXCL12	10	44876302	Missense_Mutation	SNP	A	TCGA-CN-6012-01A-11D-1683-08	763752	44876302	90658445	66	14629											
ERCC6	2074	broad.mit.edu	37	chr10	50732560	50732560	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttttattttgcactggggCtggaggcgtgactggggctg	4	14	17	6	1	0	1	0	1	0	0	0	2	0	2	0	6	1	4	0	6	1	5			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:50732560C>A	uc001jhs.3	-	5	1070	c.916G>T	c.(916-918)GCC>TCC	p.A306S	PGBD3_uc001jht.2_5'Flank|PGBD3_uc009xoe.2_Missense_Mutation_p.A306S|PGBD3_uc001jhu.2_Missense_Mutation_p.A306S	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	306					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						TGCACTGGGGCTGGAGGCGTG	0.428								Direct_reversal_of_damage|NER					66	110					5.00936e-31	6.35244e-31	1	0	A	50732560	A	A	50732560	3	1	71	1	0	0	0	0	1	0	0	0	5241	797	28	4	3633	4	ERCC6	10	50732560	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	5856258	50732560	84802187	67	14630											
PPRC1	23082	broad.mit.edu	37	chr10	103900410	103900410	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcgtggagtcagagtcCttggacccaccaaagaccat	10	8	9	14	1	1	2	1	0	0	2	4	4	3	4	5	2	0	0	5	2	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:103900410C>T	uc001kum.2	+	5	2184	c.2145C>T	c.(2143-2145)TCC>TCT	p.S715S	PPRC1_uc001kun.2_Silent_p.S595S|PPRC1_uc010qqj.1_Silent_p.S715S|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	715					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGTCAGAGTCCTTGGACCCAC	0.532													8	61					0	0	0	0	T	103900410	T	T	103900410	2	4	71	1	0	0	0	0	0	0	0	1	12470	668	24	4		4	PPRC1	10	103900410	Silent	SNP	C	TCGA-CN-6012-01A-11D-1683-08	53167850	103900410	31634337	68	14631											
SORCS1	114815	broad.mit.edu	37	chr10	108923927	108923927	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgactcgcgccctctccccGttctgccttctcctgatccg	2	11	7	21	5	3	1	0	1	3	0	7	2	4	1	7	0	1	1	7	0	0	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:108923927G>A	uc001kym.2	-	1	366	c.358C>T	c.(358-360)CGG>TGG	p.R120W	SORCS1_uc001kyl.2_Missense_Mutation_p.R120W|SORCS1_uc009xxs.2_Missense_Mutation_p.R120W|SORCS1_uc001kyn.1_Missense_Mutation_p.R120W|SORCS1_uc001kyo.2_Missense_Mutation_p.R120W	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	120	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CCCTCTCCCCGTTCTGCCTTC	0.701													5	28					0	0	0	0	A	108923927	A	A	108923927	3	1	71	1	0	0	0	0	1	0	0	0	14994	1144	40	1	3486	1	SORCS1	10	108923927	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	5023517	108923927	26610820	69	14632											
ANO3	63982	broad.mit.edu	37	chr11	26529794	26529794	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacctcagagcagaaggcttGatgttggagaaggaggtagg	13	7	16	5	0	1	4	1	1	0	3	1	6	1	5	1	5	2	4	1	5	4	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:26529794G>C	uc001mqt.3	+	5	721	c.576G>C	c.(574-576)TTG>TTC	p.L192F	ANO3_uc010rdr.1_Missense_Mutation_p.L176F|ANO3_uc010rds.1_Missense_Mutation_p.L46F|ANO3_uc010rdt.1_Missense_Mutation_p.L46F	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	192	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAGAAGGCTTGATGTTGGAGA	0.299													19	20					0	0	0	0	C	26529794	C	C	26529794	3	2	71	1	0	0	0	0	1	0	0	0	698	1281	45	2	594	2	ANO3	11	26529794	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08		26529794	108476722	70	14633											
OR4C3	256144	broad.mit.edu	37	chr11	48346829	48346829	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcattgctgactcattgtatGaggggagaaccatctcttat	10	14	9	8	0	3	3	2	2	1	1	4	4	3	3	1	2	2	2	1	2	3	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:48346829G>A	uc010rhv.1	+	1	337	c.337G>A	c.(337-339)GAG>AAG	p.E113K		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTCATTGTATGAGGGGAGAAC	0.443													10	204					0	0	0	0	A	48346829	A	A	48346829	3	1	71	1	0	0	0	0	1	0	0	0	11104	1291	45	2	339	2	OR4C3	11	48346829	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	21817035	48346829	86659687	71	14634											
OR5J2	282775	broad.mit.edu	37	chr11	55944828	55944828	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacctgtgcctctcacctGactgctgtgaccatattcta	7	13	6	15	0	2	2	1	2	2	0	4	2	3	2	5	0	2	1	5	0	2	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:55944828G>T	uc010rjb.1	+	1	735	c.735G>T	c.(733-735)CTG>CTT	p.L245L		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					CCTCTCACCTGACTGCTGTGA	0.438													10	77					3.86212e-05	4.27766e-05	1	0	T	55944828	T	T	55944828	2	4	71	1	0	0	0	0	0	0	0	1	11219	1277	45	2		2	OR5J2	11	55944828	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	7597999	55944828	79061688	72	14635											
OR5T2	219464	broad.mit.edu	37	chr11	56000661	56000661	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttgtatatactgtacgacaTatattcagcagtgcataatt	13	15	6	7	1	1	0	1	0	0	0	1	1	1	0	0	0	4	4	0	0	7	10			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:56000661T>C	uc010rjc.1	-	1	1	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CTGTACGACATATATTCAGCA	0.373													42	52					0	0	0	0	C	56000661	C	C	56000661	3	2	71	1	0	0	0	0	1	0	0	0	11236	1420	49	5	1077	5	OR5T2	11	56000661	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08	55833	56000661	79005855	73	14636											
PPFIA1	8500	broad.mit.edu	37	chr11	70172809	70172809	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagagccaaatgaaagaacGcctggcttccctttccagtc	12	8	8	13	1	0	3	0	1	0	2	3	3	2	3	4	1	2	1	4	1	3	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:70172809G>C	uc001opo.2	+	7	1013	c.815G>C	c.(814-816)CGC>CCC	p.R272P	PPFIA1_uc001opn.1_Missense_Mutation_p.R272P|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	272	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			ATGAAAGAACGCCTGGCTTCC	0.423													61	878					0	0	0	0	C	70172809	C	C	70172809	3	2	71	1	0	0	0	0	1	0	0	0	12364	1087	38	3	837	3	PPFIA1	11	70172809	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	14172148	70172809	64833707	74	14637											
DDX10	1662	broad.mit.edu	37	chr11	108788633	108788633	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaagcctttctggattggAgtgatgatgatgatgatgat	11	13	14	3	0	1	6	0	6	1	0	1	9	1	9	1	3	1	0	1	3	1	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:108788633A>G	uc001pkm.2	+	17	2403	c.2338A>G	c.(2338-2340)AGT>GGT	p.S780G	DDX10_uc001pkl.1_Missense_Mutation_p.S780G	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	780							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		TCTGGATTGGAGtgatgatga	0.318			T	NUP98	AML*								3	65					0	0	0	0	G	108788633	G	G	108788633	3	3	71	1	0	0	0	0	1	0	0	0	4359	304	11	5	2404	5	DDX10	11	108788633	Missense_Mutation	SNP	A	TCGA-CN-6012-01A-11D-1683-08	38615824	108788633	26217883	75	14638											
SLC6A13	6540	broad.mit.edu	37	chr12	333173	333173	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcacctctgtgagcatgatCagccccacaaggaaggagac	12	6	10	13	0	3	3	2	2	1	1	3	5	3	4	3	2	2	1	3	2	2	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:333173C>G	uc001qic.1	-	11	1349	c.1296G>C	c.(1294-1296)CTG>CTC	p.L432L	SLC6A13_uc009zdj.1_Silent_p.L422L|SLC6A13_uc010sdl.1_Silent_p.L340L	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	432	Helical; Name=9; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TGAGCATGATCAGCCCCACAA	0.592													4	60					0	0	0	0	G	333173	G	G	333173	2	3	71	1	0	0	0	0	0	0	0	1	14740	813	29	2		2	SLC6A13	12	333173	Silent	SNP	C	TCGA-CN-6012-01A-11D-1683-08		333173	133518722	76	14639											
TAS2R14	50840	broad.mit.edu	37	chr12	11091182	11091182	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agtgtgctgcatcttcttgcGatgtttccacatggagaaga	9	13	11	8	1	2	2	0	0	2	2	3	4	3	2	1	1	3	3	1	1	1	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:11091182G>C	uc010shi.1	-	1	625	c.625C>G	c.(625-627)CGC>GGC	p.R209G	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_023922	NP_076411	Q9NYV8	T2R14_HUMAN	taste receptor, type 2, member 14	209	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste		bitter taste receptor activity				0						ATCTTCTTGCGATGTTTCCAC	0.433													12	59					0	0	0	0	C	11091182	C	C	11091182	3	2	71	1	0	0	0	0	1	0	0	0	15634	1058	37	3	331	3	TAS2R14	12	11091182	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	10758009	11091182	122760713	77	14640											
C12orf60	144608	broad.mit.edu	37	chr12	14976222	14976222	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	taaagaagtattcaaaagtgCccatacgccagtcatcatct	15	10	6	10	1	4	1	3	0	1	1	4	1	4	1	2	0	2	1	2	0	7	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:14976222C>T	uc001rcj.3	+	2	557	c.353C>T	c.(352-354)GCC>GTC	p.A118V		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	118										ovary(1)|central_nervous_system(1)	2						TTCAAAAGTGCCCATACGCCA	0.428													5	103					0	0	0	0	T	14976222	T	T	14976222	3	4	71	1	0	0	0	0	1	0	0	0	1709	739	26	4	355	4	C12orf60	12	14976222	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	3885040	14976222	118875673	78	14641											
KRT77	374454	broad.mit.edu	37	chr12	53086338	53086338	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggactgctgcagggcctcctCcaggtcctgcagcttctgcc	4	9	12	16	0	1	0	0	0	1	0	4	1	4	1	5	3	5	4	5	3	0	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:53086338C>G	uc001saw.2	-	7	1323	c.1294G>C	c.(1294-1296)GAG>CAG	p.E432Q	KRT77_uc009zmi.2_Missense_Mutation_p.E190Q	NM_175078	NP_778253	Q7Z794	K2C1B_HUMAN	keratin 77	432	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(1)	1						AGGGCCTCCTCCAGGTCCTGC	0.622													9	38					0	0	0	0	G	53086338	G	G	53086338	3	3	71	1	0	0	0	0	1	0	0	0	8529	864	30	2	454	2	KRT77	12	53086338	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	38110116	53086338	80765557	79	14642											
SLC16A7	9194	broad.mit.edu	37	chr12	60169150	60169150	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagtgttagcagtgttctCtttgaaactctcatggacct	8	14	11	8	0	2	1	1	1	2	0	4	3	2	3	1	2	2	3	1	2	2	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:60169150C>G	uc001sqs.2	+	5	1373	c.1074C>G	c.(1072-1074)CTC>CTG	p.L358L	SLC16A7_uc001sqt.2_Silent_p.L358L|SLC16A7_uc001squ.2_Silent_p.L358L|SLC16A7_uc009zqi.2_Silent_p.L259L|SLC16A7_uc010ssi.1_Silent_p.L259L	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	358	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	GCAGTGTTCTCTTTGAAACTC	0.502													18	123					0	0	0	0	G	60169150	G	G	60169150	2	3	71	1	0	0	0	0	0	0	0	1	14478	900	32	2		2	SLC16A7	12	60169150	Silent	SNP	C	TCGA-CN-6012-01A-11D-1683-08	7082812	60169150	73682745	80	14643											
RAB3IP	117177	broad.mit.edu	37	chr12	70206629	70206629	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggggactcaagcaactattAttatatttctcctttttgca	11	16	6	8	0	2	0	1	0	1	0	3	1	2	1	1	2	3	2	1	2	6	7			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:70206629A>C	uc001svp.2	+	9	1697	c.1250A>C	c.(1249-1251)TAT>TCT	p.Y417S	RAB3IP_uc001svm.2_Missense_Mutation_p.Y401S|RAB3IP_uc001svn.2_Intron|RAB3IP_uc001svo.2_RNA|RAB3IP_uc001svq.2_Intron|RAB3IP_uc001svr.2_Intron|RAB3IP_uc001svs.2_RNA|RAB3IP_uc001svt.2_Missense_Mutation_p.Y195S	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	417					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			AGCAACTATTATTATATTTCT	0.328													23	59					0	0	0	0	C	70206629	C	C	70206629	3	2	71	1	0	0	0	0	1	0	0	0	13003	449	16	5	1284	5	RAB3IP	12	70206629	Missense_Mutation	SNP	A	TCGA-CN-6012-01A-11D-1683-08	10037479	70206629	63645266	81	14644											
HSP90B1	7184	broad.mit.edu	37	chr12	104337038	104337038	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctaaggagagtcgtgaagcaGttgagaaagaatttgagcct	14	9	13	5	1	0	5	0	3	0	3	1	7	0	5	1	1	2	2	1	1	4	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:104337038G>T	uc001tkb.1	+	13	1936	c.1831G>T	c.(1831-1833)GTT>TTT	p.V611F	HSP90B1_uc010swg.1_Missense_Mutation_p.V276F|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	611					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	TCGTGAAGCAGTTGAGAAAGA	0.418													15	33					8.60227e-14	1.03109e-13	1	0	T	104337038	T	T	104337038	3	4	71	1	0	0	0	0	1	0	0	0	7442	1029	36	4	1881	4	HSP90B1	12	104337038	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	34130409	104337038	29514857	82	14645											
RCBTB2	1102	broad.mit.edu	37	chr13	49076892	49076892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgccacgtgacggcgggcGtggcaaagcaggcaaacacg	10	2	17	12	6	0	1	0	1	0	0	0	1	0	1	1	5	2	3	1	5	2	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr13:49076892G>A	uc001vch.2	-	11	1456	c.1085C>T	c.(1084-1086)ACG>ATG	p.T362M	RCBTB2_uc010tgg.1_Missense_Mutation_p.T367M|RCBTB2_uc001vci.2_Missense_Mutation_p.T338M|RCBTB2_uc010tgh.1_Missense_Mutation_p.T88M|RCBTB2_uc001vcj.2_Missense_Mutation_p.T314M|RCBTB2_uc010acv.1_RNA|RCBTB2_uc010tgi.1_3'UTR	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	362	RCC1 6.						Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		GACGGCGGGCGTGGCAAAGCA	0.612													5	57					0	0	0	0	A	49076892	A	A	49076892	3	1	71	1	0	0	0	0	1	0	0	0	13237	1145	40	1	590	1	RCBTB2	13	49076892	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08		49076892	66092986	83	14646											
FARP1	10160	broad.mit.edu	37	chr13	99047720	99047720	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtaaacctcagcccccgcaGccaagcacaggtccagcatc	12	4	8	17	1	1	0	1	0	0	0	3	0	2	0	5	1	5	4	5	1	3	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr13:99047720G>A	uc001vnj.2	+	13	1740	c.1404G>A	c.(1402-1404)CAG>CAA	p.Q468Q	FARP1_uc001vnh.2_Silent_p.Q468Q	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	468					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGCCCCCGCAGCCAAGCACAG	0.592													31	41					0	0	0	0	A	99047720	A	A	99047720	2	1	71	1	0	0	0	0	0	0	0	1	5708	962	34	4		4	FARP1	13	99047720	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	49970828	99047720	16122158	84	14647											
ATP11A	23250	broad.mit.edu	37	chr13	113481200	113481200	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggacctcaatgaagagctgGgacaggttggtgtctcctga	9	9	14	9	1	2	3	1	2	1	1	3	5	2	5	2	4	1	2	2	4	2	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr13:113481200G>A	uc001vsi.3	+	12	1304	c.1216G>A	c.(1216-1218)GGA>AGA	p.G406R	ATP11A_uc001vsj.3_Missense_Mutation_p.G406R|ATP11A_uc001vsm.1_Missense_Mutation_p.G282R	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	406	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TGAAGAGCTGGGACAGGTTGG	0.547													5	13					0	0	0	0	A	113481200	A	A	113481200	3	1	71	1	0	0	0	0	1	0	0	0	1121	1233	43	4	1262	4	ATP11A	13	113481200	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	14433480	113481200	1688678	85	14648											
OR11G2	390439	broad.mit.edu	37	chr14	20665703	20665703	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctctttgtgctcttcaCtgttgtttacctcctgaccc	3	17	5	16	0	3	1	1	1	2	0	5	1	5	1	5	0	2	3	5	0	1	5			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:20665703C>A	uc010tlb.1	+	1	209	c.209C>A	c.(208-210)ACT>AAT	p.T70N		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	70	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GTGCTCTTCACTGTTGTTTAC	0.567													58	48					6.20943e-19	7.76179e-19	1	0	A	20665703	A	A	20665703	3	1	71	1	0	0	0	0	1	0	0	0	10979	565	20	4	211	4	OR11G2	14	20665703	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08		20665703	86683837	86	14649											
NYNRIN	57523	broad.mit.edu	37	chr14	24886290	24886290	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtggtgggagatgagcagcGcaaacattgaagggctcaag	12	7	16	6	1	1	3	1	2	0	1	1	4	1	3	0	3	3	3	0	3	3	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:24886290G>A	uc001wpf.3	+	9	5653	c.5335G>A	c.(5335-5337)GCA>ACA	p.A1779T		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1779					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GATGAGCAGCGCAAACATTGA	0.617													4	137					0	0	0	0	A	24886290	A	A	24886290	3	1	71	1	0	0	0	0	1	0	0	0	10850	1087	38	1	5365	1	NYNRIN	14	24886290	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	4220587	24886290	82463250	87	14650											
SYNE2	23224	broad.mit.edu	37	chr14	64491050	64491050	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagcatgtgaagaagcatCtgcccaaagcacatgtgaag	15	7	11	8	0	1	4	0	3	1	1	1	4	1	4	1	0	4	3	1	0	5	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:64491050C>T	uc001xgm.2	+	39	5943	c.5713C>T	c.(5713-5715)CTG>TTG	p.L1905L	SYNE2_uc001xgl.2_Silent_p.L1905L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1905	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAAGAAGCATCTGCCCAAAGC	0.433													29	41					0	0	0	0	T	64491050	T	T	64491050	2	4	71	1	0	0	0	0	0	0	0	1	15512	912	32	2		2	SYNE2	14	64491050	Silent	SNP	C	TCGA-CN-6012-01A-11D-1683-08	39604760	64491050	42858490	88	14651											
PCNX	22990	broad.mit.edu	37	chr14	71543136	71543136	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctcttcccgaagagcaaaGgtagagtttatttcatttat	11	15	8	7	1	2	2	1	0	1	2	3	3	3	2	1	1	2	4	1	1	5	7			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:71543136G>T	uc001xmo.2	+	28	5783	c.5337G>T	c.(5335-5337)AAG>AAT	p.K1779N	PCNX_uc010are.1_Missense_Mutation_p.K1668N|PCNX_uc010arf.1_Missense_Mutation_p.K567N	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1779						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GAAGAGCAAAGGTAGAGTTTA	0.403													8	23					0.000157383	0.000171069	1	0	T	71543136	T	T	71543136	3	4	71	1	0	0	0	0	1	0	0	0	11645	1014	35	4	5447	4	PCNX	14	71543136	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	7052086	71543136	35806404	89	14652											
TMEM63C	57156	broad.mit.edu	37	chr14	77715746	77715746	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgccgtctcccaggccatCtttgcgccactcttgggtct	3	12	10	16	2	4	0	0	0	4	0	5	0	4	0	4	2	2	1	4	2	0	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:77715746C>G	uc001xtf.2	+	21	2195	c.1983C>G	c.(1981-1983)ATC>ATG	p.I661M	TMEM63C_uc010asq.1_Missense_Mutation_p.I661M	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	661	Helical; (Potential).					integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		CCCAGGCCATCTTTGCGCCAC	0.562													9	48					0	0	0	0	G	77715746	G	G	77715746	3	3	71	1	0	0	0	0	1	0	0	0	16258	903	32	2	2057	2	TMEM63C	14	77715746	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	6172610	77715746	29633794	90	14653											
EML1	2009	broad.mit.edu	37	chr14	100376629	100376629	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgactttctctgaaaacggTgacaccattactggagattc	11	12	9	9	1	1	4	0	3	1	1	3	5	1	4	1	2	2	0	1	2	3	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:100376629T>G	uc001ygs.2	+	12	1359	c.1290T>G	c.(1288-1290)GGT>GGG	p.G430G	EML1_uc010tww.1_Silent_p.G418G|EML1_uc001ygq.2_Silent_p.G449G|EML1_uc001ygr.2_Silent_p.G449G	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	430	WD 4.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				CTGAAAACGGTGACACCATTA	0.333													12	73					0	0	0	0	G	100376629	G	G	100376629	2	3	71	1	0	0	0	0	0	0	0	1	5120	1683	59	5		5	EML1	14	100376629	Silent	SNP	T	TCGA-CN-6012-01A-11D-1683-08	22660883	100376629	6972911	91	14654											
EIF2AK4	440275	broad.mit.edu	37	chr15	40313219	40313219	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcagaaatcatgtacgaCtggtcacaggtaatgggaca	15	7	11	8	1	2	1	2	0	0	1	2	3	2	2	0	3	2	3	0	3	3	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr15:40313219C>T	uc001zkm.1	+	31	4343	c.4293C>T	c.(4291-4293)GAC>GAT	p.D1431D	EIF2AK4_uc010bbj.1_Silent_p.D1132D|EIF2AK4_uc001zkn.1_Silent_p.D531D|EIF2AK4_uc001zko.1_Silent_p.D312D|EIF2AK4_uc010bbk.1_RNA	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	1431	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TCATGTACGACTGGTCACAGG	0.473													5	36					0	0	0	0	T	40313219	T	T	40313219	2	4	71	1	0	0	0	0	0	0	0	1	5021	564	20	4		4	EIF2AK4	15	40313219	Silent	SNP	C	TCGA-CN-6012-01A-11D-1683-08		40313219	62218173	92	14655											
CAPN3	825	broad.mit.edu	37	chr15	42703502	42703502	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggagcttttcatgcatttGacaaggatggagatggtatc	11	12	12	6	0	1	2	1	1	0	1	2	5	1	4	0	4	2	3	0	4	2	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr15:42703502G>C	uc001zpn.1	+	23	2704	c.2398G>C	c.(2398-2400)GAC>CAC	p.D800H	CAPN3_uc001zpk.1_Missense_Mutation_p.D567H|CAPN3_uc001zpl.1_Missense_Mutation_p.D707H|CAPN3_uc010udf.1_Missense_Mutation_p.D713H|CAPN3_uc010udg.1_Missense_Mutation_p.D665H|CAPN3_uc001zpo.1_Missense_Mutation_p.D794H|CAPN3_uc001zpp.1_Missense_Mutation_p.D708H|CAPN3_uc001zpq.1_Missense_Mutation_p.D288H|CAPN3_uc010bcv.1_Missense_Mutation_p.D135H|CAPN3_uc001zpr.1_Missense_Mutation_p.D135H|CAPN3_uc001zps.1_Missense_Mutation_p.D135H|CAPN3_uc001zpt.1_Missense_Mutation_p.D135H	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	800	EF-hand 4.|Domain IV.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		TCATGCATTTGACAAGGATGG	0.498													16	61					0	0	0	0	C	42703502	C	C	42703502	3	2	71	1	0	0	0	0	1	0	0	0	2640	1290	45	2	2540	2	CAPN3	15	42703502	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	2390283	42703502	59827890	93	14656											
C15orf27	123591	broad.mit.edu	37	chr15	76452436	76452436	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttatcgtgtccattgcagTttccagcgcattccagtttg	6	15	8	12	2	0	0	0	0	0	0	4	0	3	0	4	0	2	4	4	0	1	5			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr15:76452436T>C	uc002bbq.2	+	5	538	c.383T>C	c.(382-384)TTT>TCT	p.F128S	C15orf27_uc010bkp.2_5'UTR|C15orf27_uc002bbr.2_5'UTR	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	128						integral to membrane					0						TCCATTGCAGTTTCCAGCGCA	0.557													27	123					0	0	0	0	C	76452436	C	C	76452436	3	2	71	1	0	0	0	0	1	0	0	0	1794	1739	60	5	397	5	C15orf27	15	76452436	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08	33748934	76452436	26078956	94	14657											
ABCC1	4363	broad.mit.edu	37	chr16	16232272	16232272	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgggccctgctgaggaagacGaagatccttgtgttggatga	9	9	15	8	2	0	4	0	2	0	2	1	7	1	6	2	3	1	2	2	3	2	2	rs36115566		TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr16:16232272G>A	uc010bvi.2	+	30	4519	c.4344G>A	c.(4342-4344)ACG>ACA	p.T1448T	ABCC1_uc010bvj.2_Silent_p.T1389T|ABCC1_uc010bvk.2_Silent_p.T1392T|ABCC1_uc010bvl.2_Intron|ABCC1_uc010bvm.2_Silent_p.T1333T|ABCC1_uc002del.3_Silent_p.T1342T	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1448	ABC transporter 2.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TGAGGAAGACGAAGATCCTTG	0.597													7	41					0	0	0	0	A	16232272	A	A	16232272	2	1	71	1	0	0	0	0	0	0	0	1	49	1045	37	1		1	ABCC1	16	16232272	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08		16232272	74122481	95	14658											
CAPNS2	84290	broad.mit.edu	37	chr16	55601269	55601269	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgccggtatgctaatgaaGatggagatatggattttaac	12	12	11	6	2	0	3	0	1	0	2	1	5	1	4	2	3	2	2	2	3	5	5			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr16:55601269G>C	uc002eid.1	+	1	686	c.601G>C	c.(601-603)GAT>CAT	p.D201H	LPCAT2_uc002eie.3_Intron|LPCAT2_uc002eic.2_Intron	NM_032330	NP_115706	Q96L46	CPNS2_HUMAN	calpain small subunit 2	201	EF-hand 3.					cytoplasm|plasma membrane	calcium ion binding				0						TGCTAATGAAGATGGAGATAT	0.488													12	171					0	0	0	0	C	55601269	C	C	55601269	3	2	71	1	0	0	0	0	1	0	0	0	2646	942	33	2	603	2	CAPNS2	16	55601269	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	39368997	55601269	34753484	96	14659											
CNGB1	1258	broad.mit.edu	37	chr16	57954416	57954416	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttgatgatggcgctatttGtgctggccgtggaggccgca	5	11	16	9	4	0	2	0	2	0	0	0	3	0	3	2	4	1	4	2	4	1	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr16:57954416G>T	uc002emt.2	-	19	1741	c.1676C>A	c.(1675-1677)ACA>AAA	p.T559K	CNGB1_uc010cdh.2_Missense_Mutation_p.T553K	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	559	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GGCGCTATTTGTGCTGGCCGT	0.612													5	67					2.7689e-08	3.20899e-08	1	0	T	57954416	T	T	57954416	3	4	71	1	0	0	0	0	1	0	0	0	3615	1377	48	4	2139	4	CNGB1	16	57954416	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	2353147	57954416	32400337	97	14660											
AP1G1	164	broad.mit.edu	37	chr16	71779057	71779057	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgcctcacctgtaaggttGatgtctcccagcaaatcaag	11	10	8	12	0	3	1	2	1	1	0	4	1	3	1	3	1	2	3	3	1	3	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr16:71779057G>A	uc010cgg.2	-	19	2303	c.1989C>T	c.(1987-1989)ATC>ATT	p.I663I	AP1G1_uc002fba.2_Silent_p.I666I|AP1G1_uc002fbb.2_Silent_p.I686I|AP1G1_uc002faz.2_Silent_p.I80I	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	663					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				CTGTAAGGTTGATGTCTCCCA	0.448													4	58					0	0	0	0	A	71779057	A	A	71779057	2	1	71	1	0	0	0	0	0	0	0	1	732	1280	45	2		2	AP1G1	16	71779057	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	13824641	71779057	18575696	98	14661											
TUSC5	286753	broad.mit.edu	37	chr17	1183425	1183425	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacaagaccctgaatctgTccaagaccctctcggggcct	10	8	9	14	1	2	4	0	2	2	2	4	4	3	4	4	2	0	0	4	2	3	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:1183425T>C	uc002fsi.1	+	1	469	c.130T>C	c.(130-132)TCC>CCC	p.S44P		NM_172367	NP_758955	Q8IXB3	TUSC5_HUMAN	LOST1	44					response to biotic stimulus	integral to membrane				skin(2)	2				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCTGAATCTGTCCAAGACCCT	0.617													27	65					0	0	0	0	C	1183425	C	C	1183425	3	2	71	1	0	0	0	0	1	0	0	0	16847	1667	58	5	132	5	TUSC5	17	1183425	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08		1183425	80011785	99	14662											
POLR2A	5430	broad.mit.edu	37	chr17	7403976	7403976	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtgaagtgatgaacctcCtgatgttcctgtcgacgtgg	8	11	14	8	2	0	4	0	4	0	0	3	5	2	4	3	2	1	1	3	2	2	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:7403976C>A	uc002ghf.3	+	11	1924	c.1690C>A	c.(1690-1692)CTG>ATG	p.L564M		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	564					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				GATGAACCTCCTGATGTTCCT	0.542													12	41					7.03913e-09	8.26743e-09	1	0	A	7403976	A	A	7403976	3	1	71	1	0	0	0	0	1	0	0	0	12269	680	24	4	1732	4	POLR2A	17	7403976	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	6220551	7403976	73791234	100	14663											
TP53	7157	broad.mit.edu	37	chr17	7578553	7578553	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttgttgagggcaggggagTactgtaggaagaggaaggag	11	8	19	3	0	1	2	0	1	1	1	1	6	1	6	0	6	1	4	0	6	4	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:7578553T>G	uc002gim.2	-	5	571	c.377A>C	c.(376-378)TAC>TCC	p.Y126S	TP53_uc002gig.1_Missense_Mutation_p.Y126S|TP53_uc002gih.2_Missense_Mutation_p.Y126S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.Y126S|TP53_uc010cni.1_Missense_Mutation_p.Y126S|TP53_uc002gij.2_Missense_Mutation_p.Y126S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y33S|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.Y87S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	126	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> C (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> G (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y126*(9)|p.0?(7)|p.Y126N(6)|p.Y126_K132delYSPALNK(6)|p.Y126C(4)|p.Y126D(3)|p.Y126_N131delYSPALN(3)|p.Y126S(2)|p.V73fs*9(1)|p.?(1)|p.Y126Y(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)|p.Y126fs*24(1)|p.Y126fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAGGGGAGTACTGTAGGAA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	14					0	0	0	0	G	7578553	G	G	7578553	3	3	71	1	0	0	0	0	1	0	0	0	16448	1652	57	5	921	5	TP53	17	7578553	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08	174577	7578553	73616657	101	14664											
MYO18A	399687	broad.mit.edu	37	chr17	27417044	27417044	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagctcccgtatcttagcttCctgcctgctcaccagggact	6	11	8	16	1	2	0	1	0	1	0	4	1	4	1	4	1	4	4	4	1	2	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:27417044C>G	uc002hdt.1	-	37	5619	c.5461G>C	c.(5461-5463)GAA>CAA	p.E1821Q	MYO18A_uc010wbc.1_Missense_Mutation_p.E1354Q|MYO18A_uc002hds.2_Missense_Mutation_p.E1363Q|MYO18A_uc010csa.1_Missense_Mutation_p.E1784Q|MYO18A_uc002hdu.1_Missense_Mutation_p.E1821Q	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1821	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ATCTTAGCTTCCTGCCTGCTC	0.577													3	23					0	0	0	0	G	27417044	G	G	27417044	3	3	71	1	0	0	0	0	1	0	0	0	10118	864	30	2	727	2	MYO18A	17	27417044	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	19838491	27417044	53778166	102	14665											
GPR179	440435	broad.mit.edu	37	chr17	36483564	36483564	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacggaatctgctggggcaGtggtctcccatggacagacg	9	7	15	10	2	2	2	0	0	2	2	3	4	2	4	1	5	1	2	1	5	1	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:36483564G>A	uc002hpz.2	-	11	5909	c.5888C>T	c.(5887-5889)ACT>ATT	p.T1963I		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1963	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TGCTGGGGCAGTGGTCTCCCA	0.547													15	32					0	0	0	0	A	36483564	A	A	36483564	3	1	71	1	0	0	0	0	1	0	0	0	6712	1029	36	4	1219	4	GPR179	17	36483564	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	9066520	36483564	44711646	103	14666											
CNTNAP1	8506	broad.mit.edu	37	chr17	40839831	40839831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgcccggtttcccacgcCgtggccgcctggcagtctca	5	8	12	16	4	1	0	1	0	1	0	3	0	2	0	5	3	1	2	5	3	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:40839831C>T	uc002iay.2	+	8	1354	c.1138C>T	c.(1138-1140)CGT>TGT	p.R380C	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	380	Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity	p.R380H(1)		ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		TTTCCCACGCCGTGGCCGCCT	0.637													4	65					0	0	0	0	T	40839831	T	T	40839831	3	4	71	1	0	0	0	0	1	0	0	0	3661	652	23	1	1168	1	CNTNAP1	17	40839831	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	4356267	40839831	40355379	104	14667											
NXPH3	11248	broad.mit.edu	37	chr17	47656507	47656507	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccaagatctgctcccgaGaccacgctcagagctcagcc	10	5	9	17	2	3	3	2	0	1	3	4	4	4	3	4	0	4	3	4	0	1	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:47656507G>T	uc002ipa.2	+	2	888	c.604G>T	c.(604-606)GAC>TAC	p.D202Y	NXPH3_uc010wlw.1_Missense_Mutation_p.D202Y	NM_007225	NP_009156	O95157	NXPH3_HUMAN	neurexophilin 3 precursor	202	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				pancreas(1)|skin(1)	2	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					CTGCTCCCGAGACCACGCTCA	0.602													20	73					8.28177e-16	1.0135e-15	1	0	T	47656507	T	T	47656507	3	4	71	1	0	0	0	0	1	0	0	0	10846	942	33	2	610	2	NXPH3	17	47656507	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	6816676	47656507	33538703	105	14668											
MPO	4353	broad.mit.edu	37	chr17	56349077	56349077	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggcgaggagtgggcccaCgcggcctttgcgcttcagag	6	6	17	12	4	1	1	1	0	0	1	1	3	1	2	2	4	1	2	2	4	0	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:56349077C>T	uc002ivu.1	-	11	2146	c.1969G>A	c.(1969-1971)GTG>ATG	p.V657M		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	657					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	AGTGGGCCCACGCGGCCTTTG	0.632													15	27					0	0	0	0	T	56349077	T	T	56349077	3	4	71	1	0	0	0	0	1	0	0	0	9785	536	19	1	276	1	MPO	17	56349077	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	8692570	56349077	24846133	106	14669											
TEX19	400629	broad.mit.edu	37	chr17	80320301	80320302	+	Frame_Shift_Ins	INS	-	G	G																															agcccaggacagcctgtgcaINSggggggctctgaggcatggg																										TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:80320301_80320302insG	uc002keq.2	+	2	584_585	c.275_276insG	c.(274-276)CAGfs	p.Q92fs		NM_207459	NP_997342	Q8NA77	TEX19_HUMAN	testis expressed 19	92						nucleus					0						CAGCCTGTGCAGGGGGGCTCTG	0.649													---	---	---								G	80320302	G	G	80320301	7	5	71	1	0	1	1	0	0	0	0	0	15846	188	7	0	277	0	TEX19	17	80320301	Frame_Shift_Ins	INS	-	TCGA-CN-6012-01A-11D-1683-08	23971224	80320301	874909	107	14670											
PPP4R1	9989	broad.mit.edu	37	chr18	9559423	9559424	+	Frame_Shift_Ins	INS	-	T	T																															ctgctttactcacctgcatgINStctgaggccagagtctcata																										TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr18:9559423_9559424insT	uc002koe.1	-	14	2139_2140	c.2021_2022insA	c.(2020-2022)GACfs	p.D674fs	PPP4R1_uc002kof.2_Frame_Shift_Ins_p.D91fs|PPP4R1_uc010wzo.1_Frame_Shift_Ins_p.D520fs|PPP4R1_uc002kod.1_Frame_Shift_Ins_p.D657fs|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	674					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						TCACCTGCATGTCTGAGGCCAG	0.46													---	---	---								T	9559424	T	T	9559423	7	5	71	1	0	1	1	0	0	0	0	0	12463	1368	48	0	858	0	PPP4R1	18	9559423	Frame_Shift_Ins	INS	-	TCGA-CN-6012-01A-11D-1683-08		9559423	68517825	108	14671											
TUBB6	84617	broad.mit.edu	37	chr18	12310986	12310986	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctggtggacttagagccaGgcaccatggacagcgtgcgg	8	6	15	12	2	0	1	0	0	0	1	0	3	0	3	3	5	3	1	3	5	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr18:12310986G>A	uc002kqw.2	+	3	256	c.211G>A	c.(211-213)GGC>AGC	p.G71S	TUBB6_uc002kqv.2_5'UTR|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Intron|TUBB6_uc002kqy.2_Missense_Mutation_p.G71S	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	71					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		CTTAGAGCCAGGCACCATGGA	0.498													4	45					0	0	0	0	A	12310986	A	A	12310986	3	1	71	1	0	0	0	0	1	0	0	0	16828	1000	35	4	221	4	TUBB6	18	12310986	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	2751563	12310986	65766262	109	14672											
CELF4	56853	broad.mit.edu	37	chr18	34853090	34853090	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcaggtagccgccctgcgCgactgatgccatcagggccg	6	7	14	14	4	2	1	2	1	0	0	2	2	2	1	4	2	3	2	4	2	1	2	rs150441111	by1000genomes	TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr18:34853090C>A	uc002lae.2	-	7	1234	c.838G>T	c.(838-840)GCG>TCG	p.A280S	CELF4_uc010dnd.1_Missense_Mutation_p.A278S|CELF4_uc002lag.2_Missense_Mutation_p.A270S|CELF4_uc002laf.2_Missense_Mutation_p.A275S|CELF4_uc002lai.2_Missense_Mutation_p.A265S|CELF4_uc002lah.1_Missense_Mutation_p.A5S|CELF4_uc002laj.1_Missense_Mutation_p.R115L	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	280	Sufficient for RNA-binding and MSE- dependent splicing activity.|Ala-rich.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						CCGCCCTGCGCGACTGATGCC	0.647													42	29					2.40228e-13	2.85985e-13	1	0	A	34853090	A	A	34853090	3	1	71	1	0	0	0	0	1	0	0	0	3233	768	27	3	646	3	CELF4	18	34853090	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	22542104	34853090	43224158	110	14673											
LMAN1	3998	broad.mit.edu	37	chr18	57026573	57026574	+	5'Flank	INS	-	C	C																															gattggcagagcccgggggaINScccccaagggcaaggggtga																								rs140141851	by1000genomes	TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr18:57026573_57026574insC	uc002lhz.2	-						LMAN1_uc010xek.1_5'Flank	NM_005570	NP_005561	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1 precursor						blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	AGCCCGGGGGACCCCCAAGGGC	0.752													---	---	---								C	57026574	C	C	57026573	6	5	71	0	1	1	1	0	0	0	0	0	8878	290	10	0		0	LMAN1	18	57026573	5'Flank	INS	-	TCGA-CN-6012-01A-11D-1683-08	22173483	57026573	21050675	111	14674											
SH3GL1	6455	broad.mit.edu	37	chr19	4366921	4366921	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcacgcagtttcttcctcAccttctccatctctttgaag	7	14	6	14	1	4	1	1	1	3	0	7	2	5	1	3	0	1	3	3	0	1	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:4366921A>G	uc002maj.2	-	2	220	c.114_splice	c.e2+1	p.K38_splice	SH3GL1_uc002mak.2_Splice_Site_p.K38_splice|SH3GL1_uc010xig.1_Splice_Site_p.K38_splice	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1						central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		TTTCTTCCTCACCTTCTCCAT	0.597			T	MLL	AL								32	229					0	0	0	0	G	4366921	G	G	4366921	5	3	71	1	0	0	0	0	0	0	1	0	14315	173	6	5	1026	5	SH3GL1	19	4366921	Splice_Site	SNP	A	TCGA-CN-6012-01A-11D-1683-08		4366921	54762062	112	14675											
ELAVL3	1995	broad.mit.edu	37	chr19	11568882	11568882	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcagggggctcaccggaaaCgctgggtctgatggtgtagg	7	7	19	8	2	2	1	1	1	1	0	2	2	2	2	1	7	1	4	1	7	2	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:11568882C>T	uc002mry.1	-	5	1087	c.707G>A	c.(706-708)CGT>CAT	p.R236H	ELAVL3_uc002mrx.1_Missense_Mutation_p.R236H	NM_001420	NP_001411	Q14576	ELAV3_HUMAN	ELAV-like protein 3 isoform 1	236					cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			ovary(1)|breast(1)|skin(1)	3						TCACCGGAAACGCTGGGTCTG	0.677													11	26					0	0	0	0	T	11568882	T	T	11568882	3	4	71	1	0	0	0	0	1	0	0	0	5075	536	19	1	408	1	ELAVL3	19	11568882	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	7201961	11568882	47560101	113	14676											
IL27RA	9466	broad.mit.edu	37	chr19	14153306	14153306	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacccctgacccctgttgaGatccaagatttggagctagc	10	10	9	12	0	0	3	0	2	0	2	1	5	1	4	5	1	3	2	5	1	3	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:14153306G>C	uc002mxx.2	+	5	999	c.576G>C	c.(574-576)GAG>GAC	p.E192D		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	192	Extracellular (Potential).|Fibronectin type-III 1.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						CCCCTGTTGAGATCCAAGATT	0.567											OREG0025302	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	130					0	0	0	0	C	14153306	C	C	14153306	3	2	71	1	0	0	0	0	1	0	0	0	7720	933	33	2	594	2	IL27RA	19	14153306	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	2584424	14153306	44975677	114	14677											
UBA52	7311	broad.mit.edu	37	chr19	18685943	18685945	+	In_Frame_Del	DEL	AAG	-	-																															acaccaacaacctgcgtcccAagaagaaggtcaaataaggt																										TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:18685943_18685945delAAG	uc002njr.2	+	5	484_486	c.370_372delAAG	c.(370-372)AAGdel	p.K126del	UBA52_uc002njs.2_In_Frame_Del_p.K126del|UBA52_uc002njt.2_In_Frame_Del_p.K126del	NM_001033930	NP_001029102	P62987	RL40_HUMAN	ubiquitin and ribosomal protein L40 precursor	126					activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome				0						CCTGCGTCCCAAGAAGAAGGTCA	0.567													---	---	---								-	18685945	-	-	18685943	7	5	71	1	0	1	0	1	0	0	0	0	16899	131	5	0	384	0	UBA52	19	18685943	In_Frame_Del	DEL	AAG	TCGA-CN-6012-01A-11D-1683-08	4532637	18685943	40443040	115	14678											
ZNF208	7757	broad.mit.edu	37	chr19	22156075	22156075	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagattggttaaaagctttGccacattcttcacatttgta	11	15	7	8	0	2	1	1	0	1	1	2	1	2	1	1	1	2	4	1	1	3	7			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:22156075G>T	uc002nqp.2	-	5	1610	c.1461C>A	c.(1459-1461)GGC>GGA	p.G487G	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAAAAGCTTTGCCACATTCTT	0.353													3	42					0.004672	0.00489581	1	0	T	22156075	T	T	22156075	2	4	71	1	0	0	0	0	0	0	0	1	17833	1306	46	4		4	ZNF208	19	22156075	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	3470132	22156075	36972908	116	14679											
ZFP14	57677	broad.mit.edu	37	chr19	36831737	36831737	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaccaaaatgaattttctGatgtactctaaggtctggac	12	13	7	9	0	4	2	1	2	3	0	4	3	4	3	1	2	1	1	1	2	5	4			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:36831737G>A	uc002odx.1	-	4	1084	c.991C>T	c.(991-993)CAG>TAG	p.Q331*	ZFP14_uc010xtd.1_Nonsense_Mutation_p.Q332*|ZFP14_uc010eex.1_Nonsense_Mutation_p.Q331*	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	331	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					TGAATTTTCTGATGTACTCTA	0.403													31	177					0	0	0	0	A	36831737	A	A	36831737	4	1	71	1	0	0	0	0	0	1	0	0	17706	1299	45	2	614	2	ZFP14	19	36831737	Nonsense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	14675662	36831737	22297246	117	14680											
ZNF790	388536	broad.mit.edu	37	chr19	37311007	37311007	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttcttggtctgacacctcGactgcatgtctgaaaaataa	12	12	7	10	1	3	2	0	2	3	0	4	3	3	2	1	1	1	1	1	1	3	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:37311007G>A	uc002oew.2	-	5	358	c.239C>T	c.(238-240)TCG>TTG	p.S80L	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CTGACACCTCGACTGCATGTC	0.323													22	125					0	0	0	0	A	37311007	A	A	37311007	3	1	71	1	0	0	0	0	1	0	0	0	18229	1059	37	1	1675	1	ZNF790	19	37311007	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	479270	37311007	21817976	118	14681											
ZNF570	148268	broad.mit.edu	37	chr19	37976077	37976077	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaccttgctcatcaccagaGaattcacattggggagtcac	12	9	8	12	0	4	1	4	0	0	1	4	3	4	2	2	2	1	1	2	2	1	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:37976077G>A	uc002ogk.1	+	5	2082	c.1553G>A	c.(1552-1554)AGA>AAA	p.R518K	ZNF570_uc010efl.1_Missense_Mutation_p.R574K|ZNF570_uc010xtr.1_Missense_Mutation_p.R315K	NM_144694	NP_653295	Q96NI8	ZN570_HUMAN	zinc finger protein 570	518	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CATCACCAGAGAATTCACATT	0.269													17	138					0	0	0	0	A	37976077	A	A	37976077	3	1	71	1	0	0	0	0	1	0	0	0	18069	942	33	2	1567	2	ZNF570	19	37976077	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	665070	37976077	21152906	119	14682											
FCGBP	8857	broad.mit.edu	37	chr19	40364231	40364231	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcccgggtagaagacctcgCccagtgggtagtagcggcca	8	5	16	12	3	0	2	0	0	0	2	1	2	0	2	4	4	1	3	4	4	4	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:40364231C>A	uc002omp.3	-	31	14419	c.14411G>T	c.(14410-14412)GGC>GTC	p.G4804V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4804						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GAAGACCTCGCCCAGTGGGTA	0.657													31	118					2.47511e-08	2.88762e-08	1	0	A	40364231	A	A	40364231	3	1	71	1	0	0	0	0	1	0	0	0	5810	739	26	4	1830	4	FCGBP	19	40364231	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08	2388154	40364231	18764752	120	14683											
PSG7	5676	broad.mit.edu	37	chr19	43430101	43430101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgccggtgggttagagtccGcaaagcaggacaagtagagg	11	6	17	7	2	0	2	0	0	0	2	1	3	1	3	2	4	2	4	2	4	4	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:43430101G>A	uc002ovl.3	-	6	1169	c.1067C>T	c.(1066-1068)GCG>GTG	p.A356V	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Missense_Mutation_p.A269V|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Missense_Mutation_p.A82V|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.A269V|PSG7_uc010xwl.1_Missense_Mutation_p.A234V	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	356	Ig-like C2-type 3.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GTTAGAGTCCGCAAAGCAGGA	0.448													4	134					0	0	0	0	A	43430101	A	A	43430101	3	1	71	1	0	0	0	0	1	0	0	0	12722	1087	38	1	200	1	PSG7	19	43430101	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	3065870	43430101	15698882	121	14684											
ACPT	93650	broad.mit.edu	37	chr19	51298400	51298401	+	Frame_Shift_Del	DEL	GG	-	-																															ccagggtgcctgcgggccttGgggggccccgtgtgagccag																										TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:51298400_51298401delGG	uc002pta.1	+	11	1266_1267	c.1266_1267delGG	c.(1264-1269)TTGGGGfs	p.L422fs		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	422_423	Cytoplasmic (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TGCGGGCCTTGGGGGGCCCCGT	0.649													---	---	---								-	51298401	-	-	51298400	7	5	71	1	0	1	0	1	0	0	0	0	168	1339	47	0	1308	0	ACPT	19	51298400	Frame_Shift_Del	DEL	GG	TCGA-CN-6012-01A-11D-1683-08	7868299	51298400	7830583	122	14685											
ZNF671	79891	broad.mit.edu	37	chr19	58238851	58238851	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggggacgcaggcacttccGtccctgcagagcatcagacg	8	6	13	14	4	1	2	1	0	0	2	4	3	3	3	2	3	2	4	2	3	0	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:58238851G>A	uc002qpz.3	-	1	145	c.46C>T	c.(46-48)CGG>TGG	p.R16W	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Translation_Start_Site|ZNF671_uc010yhf.1_Translation_Start_Site	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AGGCACTTCCGTCCCTGCAGA	0.672													10	17					0	0	0	0	A	58238851	A	A	58238851	3	1	71	1	0	0	0	0	1	0	0	0	18145	1144	40	1	1574	1	ZNF671	19	58238851	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	6940451	58238851	890132	123	14686											
C20orf79	140856	broad.mit.edu	37	chr20	18794599	18794599	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatttgagagcttcccagTgtttcaggacattaggcttc	10	13	10	8	0	1	2	1	1	0	2	3	4	2	3	1	2	1	3	1	2	2	5			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr20:18794599T>A	uc002wrk.2	+	1	230	c.140T>A	c.(139-141)GTG>GAG	p.V47E	uc002wrj.1_Intron	NM_178483	NP_848578	Q9UJQ7	CT079_HUMAN	hypothetical protein LOC140856	47	SCP2.						sterol binding			skin(3)	3						AGCTTCCCAGTGTTTCAGGAC	0.507													22	40					0	0	0	0	A	18794599	A	A	18794599	3	1	71	1	0	0	0	0	1	0	0	0	2129	1696	59	5	142	5	C20orf79	20	18794599	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08		18794599	44230921	124	14687											
NFS1	9054	broad.mit.edu	37	chr20	34285652	34285652	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactctcccagccataagcaTgtgtccgggagtgtgggttc	7	10	12	12	1	1	0	0	0	1	0	4	1	2	1	3	2	2	2	3	2	1	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr20:34285652T>C	uc002xdw.1	-	3	342	c.278A>G	c.(277-279)CAT>CGT	p.H93R	NFS1_uc002xdt.1_Missense_Mutation_p.H33R|NFS1_uc002xdu.1_Missense_Mutation_p.H33R|NFS1_uc002xdv.1_RNA|NFS1_uc010zvk.1_5'UTR|NFS1_uc010zvl.1_Missense_Mutation_p.H93R|NFS1_uc002xdx.2_Missense_Mutation_p.H93R|ROMO1_uc002xdy.2_5'Flank|ROMO1_uc010gfm.2_5'Flank	NM_021100	NP_066923	Q9Y697	NFS1_HUMAN	NFS1 nitrogen fixation 1 precursor	93					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GCCATAAGCATGTGTCCGGGA	0.527													8	43					0	0	0	0	C	34285652	C	C	34285652	3	2	71	1	0	0	0	0	1	0	0	0	10439	1464	51	5	1139	5	NFS1	20	34285652	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08	15491053	34285652	28739868	125	14688											
SLC2A10	81031	broad.mit.edu	37	chr20	45353864	45353864	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggctctcctcgcctccctGgttggtggcttcctcattga	2	13	12	14	1	2	1	1	1	1	0	6	1	4	1	4	5	0	3	4	5	0	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr20:45353864G>T	uc002xsl.2	+	2	286	c.189G>T	c.(187-189)CTG>CTT	p.L63L		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	63	Helical; Name=2; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TCGCCTCCCTGGTTGGTGGCT	0.632													15	41					6.31663e-08	7.2249e-08	1	0	T	45353864	T	T	45353864	2	4	71	1	0	0	0	0	0	0	0	1	14603	1335	47	4		4	SLC2A10	20	45353864	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	11068212	45353864	17671656	126	14689											
ADAMTS5	11096	broad.mit.edu	37	chr21	28302210	28302210	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttctatcatattaccttttCttattaaaggttccaacaat	12	18	3	8	0	3	0	1	0	2	0	4	0	4	0	2	1	2	2	2	1	8	9			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr21:28302210C>G	uc002ymg.2	-	7	2949	c.2220G>C	c.(2218-2220)AAG>AAC	p.K740N		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	740	Spacer.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						ATTACCTTTTCTTATTAAAGG	0.383													5	69					0	0	0	0	G	28302210	G	G	28302210	3	3	71	1	0	0	0	0	1	0	0	0	269	912	32	2	580	2	ADAMTS5	21	28302210	Missense_Mutation	SNP	C	TCGA-CN-6012-01A-11D-1683-08		28302210	19827685	127	14690											
MORC3	23515	broad.mit.edu	37	chr21	37741775	37741775	+	Frame_Shift_Del	DEL	A	-	-																															caagaactgagaaaccagctActccttgtcactgaggaaaa																										TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr21:37741775delA	uc002yvi.2	+	15	2185	c.2109delA	c.(2107-2109)CTAfs	p.L703fs		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	703	Potential.				cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						GAAACCAGCTACTCCTTGTCA	0.388													---	---	---								-	37741775	-	-	37741775	7	5	71	1	0	1	0	1	0	0	0	0	9756	378	14	0	2167	0	MORC3	21	37741775	Frame_Shift_Del	DEL	A	TCGA-CN-6012-01A-11D-1683-08	9439565	37741775	10388120	128	14691											
LGALS1	3956	broad.mit.edu	37	chr22	38075659	38075659	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaccgtcaagctgccagatgGatacgaattcaagttcccca	12	8	9	12	2	2	1	2	0	0	1	3	4	3	2	4	1	3	2	4	1	4	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr22:38075659G>T	uc003atn.2	+	4	408	c.311G>T	c.(310-312)GGA>GTA	p.G104V		NM_002305	NP_002296	P09382	LEG1_HUMAN	galectin-1	104	Galectin.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of apoptosis	cytoplasm|extracellular space|proteinaceous extracellular matrix	galactoside binding|signal transducer activity				0	Melanoma(58;0.0574)					CTGCCAGATGGATACGAATTC	0.562													18	82					2.5808e-16	3.20312e-16	1	0	T	38075659	T	T	38075659	3	4	71	1	0	0	0	0	1	0	0	0	8778	1174	41	2	325	2	LGALS1	22	38075659	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08		38075659	13228907	129	14692											
ATXN10	25814	broad.mit.edu	37	chr22	46088932	46088932	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcttctgtttcgtgaactgcGagtggaacaggaatctctgt	8	14	11	8	2	3	1	0	1	3	0	5	4	3	3	0	2	3	1	0	2	3	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr22:46088932G>A	uc003bgm.1	+	3	622	c.365G>A	c.(364-366)CGA>CAA	p.R122Q	ATXN10_uc011aqt.1_Missense_Mutation_p.R58Q|ATXN10_uc003bgn.1_5'UTR	NM_013236	NP_037368	Q9UBB4	ATX10_HUMAN	ataxin 10	122					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				ovary(1)|kidney(1)	2		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		CGTGAACTGCGAGTGGAACAG	0.308													9	61					0	0	0	0	A	46088932	A	A	46088932	3	1	71	1	0	0	0	0	1	0	0	0	1212	1058	37	1	375	1	ATXN10	22	46088932	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	8013273	46088932	5215634	130	14693											
PKDREJ	10343	broad.mit.edu	37	chr22	46653801	46653801	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaaacttttcggcaggtaGacacattttttcactagatt	12	14	6	9	1	1	2	1	0	0	2	2	2	1	2	0	2	1	2	0	2	3	8			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr22:46653801G>A	uc003bhh.2	-	1	5419	c.5419C>T	c.(5419-5421)CTA>TTA	p.L1807L		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1807	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TCGGCAGGTAGACACATTTTT	0.403													30	254					0	0	0	0	A	46653801	A	A	46653801	2	1	71	1	0	0	0	0	0	0	0	1	12025	933	33	2		2	PKDREJ	22	46653801	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	564869	46653801	4650765	131	14694											
CELSR1	9620	broad.mit.edu	37	chr22	46760506	46760506	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtgactgccctgctcctcGcggtgcagctccacgctgac	4	8	12	17	4	0	2	0	2	0	0	3	2	2	2	3	2	4	4	3	2	0	0			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr22:46760506G>A	uc003bhw.1	-	33	8682	c.8682C>T	c.(8680-8682)CGC>CGT	p.R2894R		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2894	Cytoplasmic (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCTGCTCCTCGCGGTGCAGCT	0.692													16	64					0	0	0	0	A	46760506	A	A	46760506	2	1	71	1	0	0	0	0	0	0	0	1	3236	1074	38	1		1	CELSR1	22	46760506	Silent	SNP	G	TCGA-CN-6012-01A-11D-1683-08	106705	46760506	4544060	132	14695											
BRD1	23774	broad.mit.edu	37	chr22	50216800	50216800	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgggtgcagcctggaggcGtgtggacatcacagtaagcg	8	7	16	10	3	1	0	1	0	0	0	2	2	2	2	2	4	3	2	2	4	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr22:50216800G>A	uc003biv.2	-	1	1653	c.1166C>T	c.(1165-1167)ACG>ATG	p.T389M	BRD1_uc011arf.1_Translation_Start_Site|BRD1_uc011arg.1_Missense_Mutation_p.T389M|BRD1_uc011arh.1_Missense_Mutation_p.T389M|BRD1_uc003biu.3_Missense_Mutation_p.T389M	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	389					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCCTGGAGGCGTGTGGACATC	0.542													19	180					0	0	0	0	A	50216800	A	A	50216800	3	1	71	1	0	0	0	0	1	0	0	0	1506	1145	40	1	2058	1	BRD1	22	50216800	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	3456294	50216800	1087766	133	14696											
NLGN4X	57502	broad.mit.edu	37	chrX	6069195	6069195	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcacacagcagcaaactGagtagtatttcggatgccag	12	7	13	9	1	0	1	0	1	0	0	1	2	0	2	1	3	4	5	1	3	3	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:6069195G>T	uc010ndh.2	-	2	814	c.313C>A	c.(313-315)CAG>AAG	p.Q105K	NLGN4X_uc004crp.2_Missense_Mutation_p.Q105K|NLGN4X_uc004crq.2_Missense_Mutation_p.Q105K|NLGN4X_uc010ndi.2_Missense_Mutation_p.Q105K|NLGN4X_uc004crr.2_Missense_Mutation_p.Q105K|NLGN4X_uc010ndj.2_Missense_Mutation_p.Q105K	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	105	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GCAGCAAACTGAGTAGTATTT	0.557													11	31					2.80697e-09	3.31906e-09	1	0	T	6069195	T	T	6069195	3	4	71	1	0	0	0	0	1	0	0	0	10518	1299	45	2	2157	2	NLGN4X	23	6069195	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08		6069195	149201365	134	14697											
GRPR	2925	broad.mit.edu	37	chrX	16142365	16142365	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taataacgtgtgctccagtgGatgccagcaggtacctggct	9	10	12	10	1	0	0	0	0	0	0	1	1	1	1	3	3	5	4	3	3	3	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:16142365G>A	uc004cxj.2	+	1	942	c.289G>A	c.(289-291)GAT>AAT	p.D97N		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	97	Extracellular (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					TGCTCCAGTGGATGCCAGCAG	0.502											OREG0019682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	27					0	0	0	0	A	16142365	A	A	16142365	3	1	71	1	0	0	0	0	1	0	0	0	6847	1174	41	2	291	2	GRPR	23	16142365	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	10073170	16142365	139128195	135	14698											
FAM48B2	170067	broad.mit.edu	37	chrX	24332222	24332222	+	5'Flank	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtcagctactgcgcgccgtCtgcgcgtctgcgcgcgtgcg	2	8	16	15	9	3	0	1	0	2	0	3	0	3	0	1	1	6	1	1	1	1	1			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:24332222C>G	uc011mjw.1	-							NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2												0						TGCGCGCCGTCTGCGCGTCTG	0.677													8	32					0	0	0	0	G	24332222	G	G	24332222	1	3	71	0	1	0	0	0	0	0	0	0	5606	928	32	2		2	FAM48B2	23	24332222	5'Flank	SNP	C	TCGA-CN-6012-01A-11D-1683-08	8189857	24332222	130938338	136	14699											
IL1RAPL2	26280	broad.mit.edu	37	chrX	104993010	104993010	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcaatcttcctcctccttgTactgctggtggtcatttaca	7	15	7	12	0	2	0	1	0	1	0	5	0	5	0	3	2	4	3	3	2	3	5			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:104993010T>C	uc004elz.1	+	9	1862	c.1106T>C	c.(1105-1107)GTA>GCA	p.V369A		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	369	Helical; (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						CTCCTCCTTGTACTGCTGGTG	0.413													6	44					0	0	0	0	C	104993010	C	C	104993010	3	2	71	1	0	0	0	0	1	0	0	0	7701	1638	57	5	1136	5	IL1RAPL2	23	104993010	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08	80660788	104993010	50277550	137	14700											
GPR101	83550	broad.mit.edu	37	chrX	136113430	136113430	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacgggtaggagagagggTggatgatggacaagtagcga	12	6	20	3	2	0	2	0	1	0	1	0	8	0	6	0	6	1	2	0	6	3	2			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:136113430T>C	uc011mwh.1	-	1	404	c.404A>G	c.(403-405)CAC>CGC	p.H135R		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	135	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GGAGAGAGGGTGGATGATGGA	0.592													7	12					0	0	0	0	C	136113430	C	C	136113430	3	2	71	1	0	0	0	0	1	0	0	0	6660	1696	59	5	1125	5	GPR101	23	136113430	Missense_Mutation	SNP	T	TCGA-CN-6012-01A-11D-1683-08	31120420	136113430	19157130	138	14701											
SLITRK2	84631	broad.mit.edu	37	chrX	144906200	144906200	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggccacaccaagagagcctGagctgctgtatcaaaatatt	14	8	9	10	0	1	2	1	1	0	1	1	3	1	2	3	1	3	3	3	1	5	3			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:144906200G>C	uc004fcd.2	+	5	3247	c.2257G>C	c.(2257-2259)GAG>CAG	p.E753Q	SLITRK2_uc010nsp.2_Missense_Mutation_p.E753Q|SLITRK2_uc010nso.2_Missense_Mutation_p.E753Q|SLITRK2_uc011mwq.1_Missense_Mutation_p.E753Q|SLITRK2_uc011mwr.1_Missense_Mutation_p.E753Q|SLITRK2_uc011mws.1_Missense_Mutation_p.E753Q|SLITRK2_uc004fcg.2_Missense_Mutation_p.E753Q|SLITRK2_uc011mwt.1_Missense_Mutation_p.E753Q|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	753	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAGAGCCTGAGCTGCTGTA	0.488													13	98					0	0	0	0	C	144906200	C	C	144906200	3	2	71	1	0	0	0	0	1	0	0	0	14807	1291	45	2	2259	2	SLITRK2	23	144906200	Missense_Mutation	SNP	G	TCGA-CN-6012-01A-11D-1683-08	8792770	144906200	10364360	139	14702											
EIF3I	8668	broad.mit.edu	37	chr1	32696783	32696783	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccacagtacttcgaatttGagtttgaggcttaagaagct	12	12	9	8	1	0	3	0	2	0	1	1	4	0	3	1	1	2	4	1	1	4	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:32696783G>A	uc001bur.3	+	12	1497	c.964G>A	c.(964-966)GAG>AAG	p.E322K	EIF3I_uc009vuc.2_Missense_Mutation_p.E322K|EIF3I_uc001bus.2_Missense_Mutation_p.E274K	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	322	WD 5.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				CTTCGAATTTGAGTTTGAGGC	0.328													8	35					0	0	0	0	A	32696783	A	A	32696783	3	1	72	1	0	0	0	0	1	0	0	0	5043	1291	45	2	1006	2	EIF3I	1	32696783	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08		32696783	216553838	1	14703											
MAST2	23139	broad.mit.edu	37	chr1	46476424	46476424	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccgcacaaatggaagagcGactagcagagtttatttcct	13	9	9	10	2	0	2	0	0	0	2	1	4	1	3	2	1	2	3	2	1	4	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:46476424G>A	uc001cov.2	+	10	1284	c.1001G>A	c.(1000-1002)CGA>CAA	p.R334Q	MAST2_uc001cow.2_Missense_Mutation_p.R334Q|MAST2_uc001coy.1_Missense_Mutation_p.R42Q|MAST2_uc001coz.1_Missense_Mutation_p.R219Q|MAST2_uc009vya.2_Missense_Mutation_p.R256Q|MAST2_uc001cpa.2_Intron	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	334					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					ATGGAAGAGCGACTAGCAGAG	0.502													7	33					0	0	0	0	A	46476424	A	A	46476424	3	1	72	1	0	0	0	0	1	0	0	0	9378	1058	37	1	1039	1	MAST2	1	46476424	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	13779641	46476424	202774197	2	14704											
ECHDC2	55268	broad.mit.edu	37	chr1	53370495	53370495	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccagacaacggggcagcctCtgagtccctcctaccaggat	9	6	10	16	1	1	2	0	1	1	1	3	3	3	3	5	3	3	1	5	3	2	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:53370495C>T	uc001cup.3	-	7	771	c.525G>A	c.(523-525)CAG>CAA	p.Q175Q	ECHDC2_uc001cun.2_Silent_p.Q98Q|ECHDC2_uc001cuo.3_Silent_p.Q144Q|ECHDC2_uc010onk.1_Silent_p.Q129Q	NM_018281	NP_060751	Q86YB7	ECHD2_HUMAN	enoyl Coenzyme A hydratase domain containing 2	175					fatty acid metabolic process	mitochondrion	lyase activity			central_nervous_system(1)	1						GGGGCAGCCTCTGAGTCCCTC	0.622													9	26					0	0	0	0	T	53370495	T	T	53370495	2	4	72	1	0	0	0	0	0	0	0	1	4916	912	32	2		2	ECHDC2	1	53370495	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	6894071	53370495	195880126	3	14705											
PGM1	5236	broad.mit.edu	37	chr1	64095639	64095639	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctccagaagcaataactgatAaaattttccaaatcagcaag	18	9	5	9	0	1	2	1	1	0	1	3	2	3	2	2	0	3	2	2	0	7	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:64095639A>T	uc001dbh.2	+	3	649	c.436A>T	c.(436-438)AAA>TAA	p.K146*	PGM1_uc010ooy.1_5'UTR|PGM1_uc010ooz.1_Nonsense_Mutation_p.K164*	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	146					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						AATAACTGATAAAATTTTCCA	0.418													17	53					0	0	0	0	T	64095639	T	T	64095639	4	4	72	1	0	0	0	0	0	1	0	0	11852	363	13	5	750	5	PGM1	1	64095639	Nonsense_Mutation	SNP	A	TCGA-CN-6013-01A-11D-1683-08	10725144	64095639	185154982	4	14706											
C1orf173	127254	broad.mit.edu	37	chr1	75078403	75078403	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gatgcttgtattcacaacagGagcttaacctgttcacctgc	10	12	8	11	0	2	0	2	0	0	0	2	2	2	1	2	1	5	4	2	1	3	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:75078403G>A	uc001dgg.2	-	9	1310	c.1091C>T	c.(1090-1092)TCC>TTC	p.S364F	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.S158F	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	364										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TTCACAACAGGAGCTTAACCT	0.443													8	33					0	0	0	0	A	75078403	A	A	75078403	3	1	72	1	0	0	0	0	1	0	0	0	2023	1174	41	2	3525	2	C1orf173	1	75078403	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	10982764	75078403	174172218	5	14707											
SAMD13	148418	broad.mit.edu	37	chr1	84768891	84768891	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccttattgattagttgctGaagtaaaggaaccctgcagc	11	12	9	9	0	0	2	0	2	0	0	1	3	1	3	2	1	4	4	2	1	6	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:84768891G>C	uc001djr.2	+	2	208	c.16G>C	c.(16-18)GAA>CAA	p.E6Q	SAMD13_uc010orw.1_5'UTR|SAMD13_uc010orx.1_5'UTR	NM_001010971	NP_001010971	Q5VXD3	SAM13_HUMAN	sterile alpha motif domain containing 13 isoform	12											0				all cancers(265;0.00667)|Epithelial(280;0.0219)|OV - Ovarian serous cystadenocarcinoma(397;0.136)		ATTAGTTGCTGAAGTAAAGGA	0.388													12	34					0	0	0	0	C	84768891	C	C	84768891	3	2	72	1	0	0	0	0	1	0	0	0	13883	1291	45	2	22	2	SAMD13	1	84768891	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	9690488	84768891	164481730	6	14708											
HS2ST1	9653	broad.mit.edu	37	chr1	87538634	87538634	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaagggctattgcaagaCacgaagtccgagaaattgag	16	6	12	7	2	0	4	0	1	0	3	1	6	1	4	1	1	1	2	1	1	5	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:87538634C>T	uc010osk.1	+	2	527	c.142C>T	c.(142-144)CAC>TAC	p.H48Y	HS2ST1_uc001dmc.3_Missense_Mutation_p.H48Y|LOC339524_uc001dme.1_Missense_Mutation_p.H9Y	NM_012262	NP_036394	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1 isoform	48	Lumenal (Potential).					Golgi membrane|integral to membrane				central_nervous_system(1)	1		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		TATTGCAAGACACGAAGTCCG	0.408													9	19					0	0	0	0	T	87538634	T	T	87538634	3	4	72	1	0	0	0	0	1	0	0	0	7401	478	17	4	148	4	HS2ST1	1	87538634	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	2769743	87538634	161711987	7	14709											
TRIM45	80263	broad.mit.edu	37	chr1	117661121	117661121	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatctgagccagggcttcctCcagggcctccacgtggggct	5	8	14	14	1	1	1	0	1	1	0	4	2	4	1	5	4	1	2	5	4	0	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:117661121C>G	uc001egz.2	-	2	1345	c.757G>C	c.(757-759)GAG>CAG	p.E253Q	TRIM45_uc009whe.2_Missense_Mutation_p.E253Q|TRIM45_uc001eha.2_Missense_Mutation_p.E149Q	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	253						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		AGGGCTTCCTCCAGGGCCTCC	0.567													10	52					0	0	0	0	G	117661121	G	G	117661121	3	3	72	1	0	0	0	0	1	0	0	0	16587	864	30	2	1005	2	TRIM45	1	117661121	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	30122487	117661121	131589500	8	14710											
NBPF10	100132406	broad.mit.edu	37	chr1	145301725	145301725	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgtcttttctcagaatatGaagagtgcaaagacctcata	13	13	7	8	0	4	4	2	1	3	3	5	4	4	4	1	0	1	1	1	0	5	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:145301725G>A	uc001end.3	+	7	1029	c.994G>A	c.(994-996)GAA>AAA	p.E332K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.E332K|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Missense_Mutation_p.E61K	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	332											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CTCAGAATATGAAGAGTGCAA	0.507													33	385					0	0	0	0	A	145301725	A	A	145301725	3	1	72	1	0	0	0	0	1	0	0	0	10246	1291	45	2	1020	2	NBPF10	1	145301725	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	27640604	145301725	103948896	9	14711											
SEMA4A	64218	broad.mit.edu	37	chr1	156128225	156128225	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctggtttcttacaatgtcaCccatctctacacctgcggca	8	12	6	15	1	3	0	1	0	2	0	4	0	3	0	3	2	3	2	3	2	3	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:156128225C>T	uc001fnl.2	+	5	514	c.410C>T	c.(409-411)ACC>ATC	p.T137I	SEMA4A_uc009wrq.2_Missense_Mutation_p.T137I|SEMA4A_uc001fnm.2_Missense_Mutation_p.T137I|SEMA4A_uc001fnn.2_Intron|SEMA4A_uc001fno.2_Missense_Mutation_p.T137I	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	137	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					TACAATGTCACCCATCTCTAC	0.532													32	130					0	0	0	0	T	156128225	T	T	156128225	3	4	72	1	0	0	0	0	1	0	0	0	14096	507	18	4	424	4	SEMA4A	1	156128225	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	10826500	156128225	93122396	10	14712											
OR10K2	391107	broad.mit.edu	37	chr1	158390345	158390345	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgagagcagccaaggaagagGaaggaaaacatttggatggc	16	5	15	5	0	0	2	0	1	0	2	0	7	0	6	1	5	3	1	1	5	5	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:158390345G>A	uc010pii.1	-	1	312	c.312C>T	c.(310-312)TTC>TTT	p.F104F		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					CAAGGAAGAGGAAGGAAAACA	0.488													12	102					0	0	0	0	A	158390345	A	A	158390345	2	1	72	1	0	0	0	0	0	0	0	1	10968	1165	41	2		2	OR10K2	1	158390345	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	2262120	158390345	90860276	11	14713											
F5	2153	broad.mit.edu	37	chr1	169484729	169484729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtatggtttccattccactcCctgctcactgtagtggatgg	6	14	10	11	0	1	0	1	0	0	0	4	1	4	1	3	3	1	4	3	3	2	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:169484729C>T	uc001ggg.1	-	24	6626	c.6481G>A	c.(6481-6483)GGA>AGA	p.G2161R		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	2161	F5/8 type C 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CATTCCACTCCCTGCTCACTG	0.443													30	148					0	0	0	0	T	169484729	T	T	169484729	3	4	72	1	0	0	0	0	1	0	0	0	5373	632	22	4	201	4	F5	1	169484729	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	11094384	169484729	79765892	12	14714											
ANGPTL1	9068	broad.mit.edu	37	chr1	178834726	178834726	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttggtgttgacacagattggCcctgttattctttgttcagg	6	17	11	7	0	2	2	1	1	1	1	2	2	2	2	1	3	0	3	1	3	1	7			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:178834726C>T	uc001gma.2	-	3	662	c.186G>A	c.(184-186)GGG>GGA	p.G62G	RALGPS2_uc001gly.1_Intron|RALGPS2_uc001glz.2_Intron|RALGPS2_uc010pnb.1_Intron|ANGPTL1_uc001gmb.2_Silent_p.G62G|ANGPTL1_uc010pnc.1_Intron	NM_004673	NP_004664	O95841	ANGL1_HUMAN	angiopoietin-like 1 precursor	62						extracellular space	receptor binding				0						CACAGATTGGCCCTGTTATTC	0.443													3	47					0	0	0	0	T	178834726	T	T	178834726	2	4	72	1	0	0	0	0	0	0	0	1	613	726	26	4		4	ANGPTL1	1	178834726	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	9349997	178834726	70415895	13	14715											
HMCN1	83872	broad.mit.edu	37	chr1	185953402	185953402	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatacttgtgtggccagtaaCgttgctgggaccaataacaa	12	11	10	8	1	0	0	0	0	0	0	0	1	0	1	2	2	4	3	2	2	6	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:185953402C>T	uc001grq.1	+	19	3121	c.2892C>T	c.(2890-2892)AAC>AAT	p.N964N	HMCN1_uc001grr.1_Silent_p.N305N	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	964	Ig-like C2-type 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGGCCAGTAACGTTGCTGGGA	0.433													19	114					0	0	0	0	T	185953402	T	T	185953402	2	4	72	1	0	0	0	0	0	0	0	1	7259	535	19	1		1	HMCN1	1	185953402	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	7118676	185953402	63297219	14	14716											
UCHL5	51377	broad.mit.edu	37	chr1	193029108	193029108	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catcgcggtagggacatcctCgctaggcccggccggaccat	7	6	13	15	5	0	0	0	0	0	0	3	2	1	2	4	5	0	2	4	5	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:193029108C>T	uc001gsm.2	-						UCHL5_uc001gsn.2_5'Flank|UCHL5_uc001gso.2_5'Flank|UCHL5_uc010pov.1_5'Flank|UCHL5_uc001gsp.2_5'Flank|UCHL5_uc001gsq.2_5'Flank|UCHL5_uc010pow.1_5'UTR|UCHL5_uc010pox.1_5'Flank|UCHL5_uc001gsr.1_Silent_p.A7A|TROVE2_uc001gst.1_Intron|TROVE2_uc001gss.2_Intron|TROVE2_uc001gsu.1_Intron|TROVE2_uc001gsv.1_5'UTR|TROVE2_uc001gsw.2_5'UTR|TROVE2_uc009wyp.2_5'UTR|TROVE2_uc009wyq.2_5'UTR	NM_015984	NP_057068	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5						DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3						GGGACATCCTCGCTAGGCCCG	0.677													6	32					0	0	0	0	T	193029108	T	T	193029108	1	4	72	0	1	0	0	0	0	0	0	0	16990	899	31	1		1	UCHL5	1	193029108	5'Flank	SNP	C	TCGA-CN-6013-01A-11D-1683-08	7075706	193029108	56221513	15	14717											
ASPM	259266	broad.mit.edu	37	chr1	197060123	197060123	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaatctttttgatgctatGatatttctgaataaatctct	11	19	4	7	0	4	3	1	3	3	0	5	3	4	3	0	0	1	1	0	0	6	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:197060123G>C	uc001gtu.2	-	23	9750	c.9493C>G	c.(9493-9495)CAT>GAT	p.H3165D	ASPM_uc001gtv.2_Missense_Mutation_p.H1580D|ASPM_uc001gtw.3_Missense_Mutation_p.H1013D	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	3165					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTGATGCTATGATATTTCTGA	0.353													9	58					0	0	0	0	C	197060123	C	C	197060123	3	2	72	1	0	0	0	0	1	0	0	0	1058	1290	45	2	964	2	ASPM	1	197060123	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	4031015	197060123	52190498	16	14718											
NAV1	89796	broad.mit.edu	37	chr1	201789046	201789046	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatcctggaccccaaccttCaggcaacactttaagggttc	10	9	7	15	0	1	0	1	0	0	0	3	1	2	1	5	3	2	2	5	3	3	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:201789046C>T	uc001gwu.2	+	29	5958	c.5611C>T	c.(5611-5613)CAG>TAG	p.Q1871*	NAV1_uc001gwx.2_Nonsense_Mutation_p.Q1480*	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1874					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CCCCAACCTTCAGGCAACACT	0.522													6	60					0	0	0	0	T	201789046	T	T	201789046	4	4	72	1	0	0	0	0	0	1	0	0	10236	827	29	2	5795	2	NAV1	1	201789046	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	4728923	201789046	47461575	17	14719											
USH2A	7399	broad.mit.edu	37	chr1	216373392	216373392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actccttgttgaaccatgcaCattggtggtctcaatgtaat	10	14	8	9	0	1	1	1	1	1	0	3	1	2	1	2	2	2	3	2	2	3	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:216373392C>T	uc001hku.1	-	17	3775	c.3388G>A	c.(3388-3390)GTG>ATG	p.V1130M	USH2A_uc001hkv.2_Missense_Mutation_p.V1130M	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1130	Extracellular (Potential).|Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAACCATGCACATTGGTGGTC	0.363										HNSCC(13;0.011)			19	72					0	0	0	0	T	216373392	T	T	216373392	3	4	72	1	0	0	0	0	1	0	0	0	17104	478	17	4	12458	4	USH2A	1	216373392	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	14584346	216373392	32877229	18	14720											
MIA3	375056	broad.mit.edu	37	chr1	222832101	222832101	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtatgaacggcaagaaagaGagcacaggctgtcagctgca	15	5	13	8	1	1	3	1	1	0	2	1	4	1	3	0	2	4	6	0	2	4	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:222832101G>C	uc001hnl.2	+	19	4654	c.4645G>C	c.(4645-4647)GAG>CAG	p.E1549Q	MIA3_uc001hnm.2_Missense_Mutation_p.E427Q	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1549	Cytoplasmic (Potential).|Potential.				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		GCAAGAAAGAGAGCACAGGCT	0.423													3	186					0	0	0	0	C	222832101	C	C	222832101	3	2	72	1	0	0	0	0	1	0	0	0	9618	943	33	2	4719	2	MIA3	1	222832101	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	6458709	222832101	26418520	19	14721											
OR2M7	391196	broad.mit.edu	37	chr1	248487682	248487682	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatgagggacagttggctGaggaggaagtacatgggggt	10	8	18	5	0	0	2	0	2	0	0	1	5	1	5	1	6	1	3	1	6	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr1:248487682G>A	uc010pzk.1	-	1	189	c.189C>T	c.(187-189)CTC>CTT	p.L63L		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGTTGGCTGAGGAGGAAGT	0.527													45	246					0	0	0	0	A	248487682	A	A	248487682	2	1	72	1	0	0	0	0	0	0	0	1	11068	1277	45	2		2	OR2M7	1	248487682	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	25655581	248487682	762939	20	14722											
WDR35	57539	broad.mit.edu	37	chr2	20145565	20145565	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctcaggatccaagtttctGaaaacatacattcttgtctt	12	14	5	10	0	4	1	1	1	3	0	5	2	5	2	2	1	2	1	2	1	4	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:20145565G>A	uc002rdi.2	-	17	1968	c.1860C>T	c.(1858-1860)TTC>TTT	p.F620F	WDR35_uc002rdj.2_Silent_p.F609F|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Silent_p.F185F|WDR35_uc002rdk.3_Silent_p.F185F	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	620										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAAGTTTCTGAAAACATACA	0.343													41	142					0	0	0	0	A	20145565	A	A	20145565	2	1	72	1	0	0	0	0	0	0	0	1	17357	1281	45	2		2	WDR35	2	20145565	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08		20145565	223053808	21	14723											
MATN3	4148	broad.mit.edu	37	chr2	20192895	20192895	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgatgtatttgtccatattCatttattttcaacttctcca	10	19	3	9	1	3	0	2	0	1	0	5	1	4	0	2	0	1	1	2	0	4	9			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:20192895C>G	uc002rdl.2	-	8	1501	c.1438G>C	c.(1438-1440)GAA>CAA	p.E480Q		NM_002381	NP_002372	O15232	MATN3_HUMAN	matrilin 3 precursor	480	By similarity.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTCCATATTCATTTATTTTC	0.328													6	44					0	0	0	0	G	20192895	G	G	20192895	3	3	72	1	0	0	0	0	1	0	0	0	9388	835	29	2	26	2	MATN3	2	20192895	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	47330	20192895	223006478	22	14724											
SPTBN1	6711	broad.mit.edu	37	chr2	54856219	54856219	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttctgggagatggcagaaGaggaaggctggatacgggag	11	7	18	5	1	2	3	0	0	2	3	2	7	2	6	0	6	1	2	0	6	3	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:54856219G>C	uc002rxu.2	+	14	2197	c.1948G>C	c.(1948-1950)GAG>CAG	p.E650Q	SPTBN1_uc002rxv.1_Missense_Mutation_p.E650Q|SPTBN1_uc002rxx.2_Missense_Mutation_p.E637Q	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	650	Spectrin 4.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GATGGCAGAAGAGGAAGGCTG	0.597													18	91					0	0	0	0	C	54856219	C	C	54856219	3	2	72	1	0	0	0	0	1	0	0	0	15185	943	33	2	2111	2	SPTBN1	2	54856219	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	34663324	54856219	188343154	23	14725											
EXOC6B	23233	broad.mit.edu	37	chr2	72945272	72945272	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caattttgtctgaatgtttgCggatgctctccagaaagtct	9	15	9	8	1	3	2	0	1	3	1	4	3	3	3	1	1	2	2	1	1	3	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:72945272C>T	uc010fep.2	-	6	767	c.629G>A	c.(628-630)CGC>CAC	p.R210H	EXOC6B_uc002sij.2_Missense_Mutation_p.R210H	NM_015189	NP_056004	Q9Y2D4	EXC6B_HUMAN	SEC15-like 2	210					protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2						TGAATGTTTGCGGATGCTCTC	0.423													4	66					0	0	0	0	T	72945272	T	T	72945272	3	4	72	1	0	0	0	0	1	0	0	0	5333	768	27	1	1874	1	EXOC6B	2	72945272	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	18089053	72945272	170254101	24	14726											
POTEF	728378	broad.mit.edu	37	chr2	130832651	130832651	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcaggacggggtgctcctcGggagccacacgcagctcgtt	7	6	15	13	4	0	0	0	0	0	0	3	2	1	2	2	4	4	5	2	4	0	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:130832651G>A	uc010fmh.2	-	17	2794	c.2394C>T	c.(2392-2394)CCC>CCT	p.P798P		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	798	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						GGTGCTCCTCGGGAGCCACAC	0.577													4	136					0	0	0	0	A	130832651	A	A	130832651	2	1	72	1	0	0	0	0	0	0	0	1	12320	1103	39	1		1	POTEF	2	130832651	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	57887379	130832651	112366722	25	14727											
YSK4	80122	broad.mit.edu	37	chr2	135738407	135738407	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttacctggtcaggcacatgcGcacaaagtctgctgcatttt	9	12	9	11	1	2	0	1	0	1	0	2	0	2	0	1	2	4	4	1	2	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:135738407G>A	uc002tue.1	-	9	3935	c.3904C>T	c.(3904-3906)CGC>TGC	p.R1302C	YSK4_uc002tuf.1_Missense_Mutation_p.R484C|YSK4_uc010fnc.1_Missense_Mutation_p.R436C|YSK4_uc010fnd.1_Missense_Mutation_p.R1189C|YSK4_uc010zbg.1_Missense_Mutation_p.R434C|YSK4_uc002tuh.3_Missense_Mutation_p.R1030C|YSK4_uc002tui.3_3'UTR	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1302	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		AGGCACATGCGCACAAAGTCT	0.493													11	19					0	0	0	0	A	135738407	A	A	135738407	3	1	72	1	0	0	0	0	1	0	0	0	17563	1087	38	1	90	1	YSK4	2	135738407	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	4905756	135738407	107460966	26	14728											
IFIH1	64135	broad.mit.edu	37	chr2	163133418	163133418	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcttttcattttcatattCtgggttttcagccagccttt	6	19	6	10	0	4	0	3	0	1	0	4	0	4	0	2	1	3	2	2	1	1	9			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:163133418C>A	uc002uce.2	-	11	2305	c.2083G>T	c.(2083-2085)GAA>TAA	p.E695*		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	695					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						TTTTCATATTCTGGGTTTTCA	0.254													24	68					3.5997e-14	3.90219e-14	1	0	A	163133418	A	A	163133418	4	1	72	1	0	0	0	0	0	1	0	0	7559	922	32	2	1018	2	IFIH1	2	163133418	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	27395011	163133418	80065955	27	14729											
TTN	7273	broad.mit.edu	37	chr2	179444106	179444106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaggtagaccctttaagtCaagatcaggagccactgtaa	14	9	9	9	0	3	2	3	0	0	2	3	3	3	3	2	2	1	2	2	2	4	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:179444106C>T	uc010zfg.1	-	269	60171	c.59947G>A	c.(59947-59949)GAC>AAC	p.D19983N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D13678N|TTN_uc010zfi.1_Missense_Mutation_p.D13611N|TTN_uc010zfj.1_Missense_Mutation_p.D13486N|uc002umv.1_3'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20910							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTTTAAGTCAAGATCAGGA	0.393													3	19					0	0	0	0	T	179444106	T	T	179444106	3	4	72	1	0	0	0	0	1	0	0	0	16803	826	29	2	40500	2	TTN	2	179444106	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	16310688	179444106	63755267	28	14730											
TTN	7273	broad.mit.edu	37	chr2	179501496	179501496	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaactttctcctttcggctTctattggtgaaggagtcttt	6	19	8	8	1	3	1	0	1	3	0	5	2	3	2	1	3	1	1	1	3	3	7			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:179501496T>G	uc010zfg.1	-	174	33478	c.33254A>C	c.(33253-33255)GAA>GCA	p.E11085A	TTN_uc010zfh.1_Missense_Mutation_p.E4780A|TTN_uc010zfi.1_Missense_Mutation_p.E4713A|TTN_uc010zfj.1_Missense_Mutation_p.E4588A|TTN_uc010fre.1_Missense_Mutation_p.E946A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12012							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTTCGGCTTCTATTGGTGA	0.448													16	31					0	0	0	0	G	179501496	G	G	179501496	3	3	72	1	0	0	0	0	1	0	0	0	16803	1783	62	5	67287	5	TTN	2	179501496	Missense_Mutation	SNP	T	TCGA-CN-6013-01A-11D-1683-08	57390	179501496	63697877	29	14731											
TTN	7273	broad.mit.edu	37	chr2	179516230	179516230	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaccaccagaggcaccttcTtttcaggaacaacctccttg	11	9	7	14	0	2	1	1	0	1	1	3	3	3	2	5	2	3	1	5	2	3	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:179516230T>G	uc010zfg.1	-	161	32419	c.32195A>C	c.(32194-32196)AAG>ACG	p.K10732T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_RNA|TTN_uc002umx.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11659							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGCACCTTCTTTTCAGGAAC	0.473													12	41					0	0	0	0	G	179516230	G	G	179516230	3	3	72	1	0	0	0	0	1	0	0	0	16803	1609	56	5	68398	5	TTN	2	179516230	Missense_Mutation	SNP	T	TCGA-CN-6013-01A-11D-1683-08	14734	179516230	63683143	30	14732											
BARD1	580	broad.mit.edu	37	chr2	215645669	215645669	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaatggcaaagatttcttaGatgtaagataatttttgcag	14	15	8	4	0	1	3	0	0	1	3	1	3	1	3	0	1	1	3	0	1	5	7			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:215645669G>C	uc002veu.2	-	4	1064	c.929C>G	c.(928-930)TCT>TGT	p.S310C	BARD1_uc010zjm.1_Missense_Mutation_p.S166C	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	310					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGATTTCTTAGATGTAAGATA	0.403									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				23	36					0	0	0	0	C	215645669	C	C	215645669	3	2	72	1	0	0	0	0	1	0	0	0	1314	942	33	2	1436	2	BARD1	2	215645669	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	36129439	215645669	27553704	31	14733											
FAM134A	79137	broad.mit.edu	37	chr2	220046144	220046144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagccactggcagagacaGagagtgaaagcgaggcagag	15	3	16	7	1	0	5	0	2	0	3	0	8	0	5	1	2	2	2	1	2	1	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:220046144G>A	uc002vjw.3	+	7	974	c.838G>A	c.(838-840)GAG>AAG	p.E280K	FAM134A_uc010fwc.2_Missense_Mutation_p.E73K|FAM134A_uc002vjx.2_Missense_Mutation_p.E73K	NM_024293	NP_077269	Q8NC44	F134A_HUMAN	hypothetical protein LOC79137	280						endoplasmic reticulum|integral to membrane				ovary(1)|central_nervous_system(1)	2		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCAGAGACAGAGAGTGAAAG	0.532													14	24					0	0	0	0	A	220046144	A	A	220046144	3	1	72	1	0	0	0	0	1	0	0	0	5473	943	33	2	864	2	FAM134A	2	220046144	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	4400475	220046144	23153229	32	14734											
COL6A3	1293	broad.mit.edu	37	chr2	238285728	238285728	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacctctgtgcatagtccagCgcgtagcccaggttgagggc	7	9	13	12	2	1	1	0	1	1	0	2	1	2	1	3	2	4	3	3	2	3	4	rs115874872	by1000genomes	TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:238285728C>T	uc002vwl.2	-	7	3042	c.2757G>A	c.(2755-2757)GCG>GCA	p.A919A	COL6A3_uc002vwo.2_Silent_p.A713A|COL6A3_uc010znj.1_Silent_p.A312A|COL6A3_uc002vwq.2_Silent_p.A713A|COL6A3_uc002vwr.2_Silent_p.A512A|COL6A3_uc010znk.1_Silent_p.A719A	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	919	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CATAGTCCAGCGCGTAGCCCA	0.527													10	31					0	0	0	0	T	238285728	T	T	238285728	2	4	72	1	0	0	0	0	0	0	0	1	3716	755	27	1		1	COL6A3	2	238285728	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	18239584	238285728	4913645	33	14735											
ANO7	50636	broad.mit.edu	37	chr2	242135211	242135211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agacatgcacaggacctggcGggagacttttctggataatc	11	9	12	9	1	1	2	0	0	1	2	2	5	1	4	1	4	1	1	1	4	1	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr2:242135211G>A	uc002wax.2	+	4	525	c.422G>A	c.(421-423)CGG>CAG	p.R141Q	ANO7_uc002waw.2_Missense_Mutation_p.R140Q	NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	141	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						AGGACCTGGCGGGAGACTTTT	0.607													14	32					0	0	0	0	A	242135211	A	A	242135211	3	1	72	1	0	0	0	0	1	0	0	0	702	1116	39	1	436	1	ANO7	2	242135211	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	3849483	242135211	1064162	34	14736											
ZFYVE20	64145	broad.mit.edu	37	chr3	15115633	15115633	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	attccctgccactgcttcctCctcctcgtcctcttcctcga	3	14	4	20	2	1	0	0	0	1	0	9	1	7	0	7	0	2	1	7	0	0	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:15115633C>G	uc003bzm.1	-	14	2625	c.2011G>C	c.(2011-2013)GAG>CAG	p.E671Q	ZFYVE20_uc010hek.1_Missense_Mutation_p.E671Q	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	671	Poly-Glu.|Necessary for the interaction with RAB5A.|Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						ACTGCTTCCTCCTCCTCGTCC	0.567													4	138					0	0	0	0	G	15115633	G	G	15115633	3	3	72	1	0	0	0	0	1	0	0	0	17733	864	30	2	347	2	ZFYVE20	3	15115633	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08		15115633	182906797	35	14737											
RAB5A	5868	broad.mit.edu	37	chr3	20017653	20017653	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagcaaataaaagagcagtaGatttccaggtatgttaaatt	17	12	8	4	0	0	2	0	0	0	2	1	2	1	2	1	1	2	5	1	1	8	7			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:20017653G>A	uc003cbn.2	+	4	965	c.430G>A	c.(430-432)GAT>AAT	p.D144N	RAB5A_uc010hey.2_RNA|RAB5A_uc011awg.1_Missense_Mutation_p.D130N	NM_004162	NP_004153	P20339	RAB5A_HUMAN	RAB5A, member RAS oncogene family	144					blood coagulation|protein transport|receptor internalization|regulation of filopodium assembly|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GDP binding|GTP binding|GTPase activity				0						AAGAGCAGTAGATTTCCAGGT	0.343													5	24					0	0	0	0	A	20017653	A	A	20017653	3	1	72	1	0	0	0	0	1	0	0	0	13013	942	33	2	440	2	RAB5A	3	20017653	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	4902020	20017653	178004777	36	14738											
KLHL18	23276	broad.mit.edu	37	chr3	47385244	47385244	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gattgtccccatgcacacgcGcaggagccgggtctccctgg	6	7	13	15	3	1	0	0	0	1	0	3	2	2	1	4	3	2	2	4	3	0	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:47385244G>A	uc003crd.2	+	10	1664	c.1538G>A	c.(1537-1539)CGC>CAC	p.R513H	KLHL18_uc011bav.1_Missense_Mutation_p.R401H	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	513	Kelch 5.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		ATGCACACGCGCAGGAGCCGG	0.607													4	47					0	0	0	0	A	47385244	A	A	47385244	3	1	72	1	0	0	0	0	1	0	0	0	8412	1087	38	1	1576	1	KLHL18	3	47385244	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	27367591	47385244	150637186	37	14739											
ALCAM	214	broad.mit.edu	37	chr3	105269028	105269028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaaaattatcatttcccctGaagagaatgttacattaact	15	14	5	7	0	1	2	1	1	0	1	2	3	2	2	2	0	2	2	2	0	7	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:105269028G>A	uc003dvx.2	+	12	1972	c.1432G>A	c.(1432-1434)GAA>AAA	p.E478K	ALCAM_uc003dvw.1_Missense_Mutation_p.E478K|ALCAM_uc003dvy.2_Missense_Mutation_p.E478K|ALCAM_uc010hpp.2_Missense_Mutation_p.E200K|ALCAM_uc003dvz.2_Missense_Mutation_p.E112K	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	478	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						CATTTCCCCTGAAGAGAATGT	0.348													7	199					0	0	0	0	A	105269028	A	A	105269028	3	1	72	1	0	0	0	0	1	0	0	0	487	1291	45	2	1478	2	ALCAM	3	105269028	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	57883784	105269028	92753402	38	14740											
KIAA1524	57650	broad.mit.edu	37	chr3	108308177	108308177	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacttcacggctttgtactGactgacagtcaggagcaagg	10	10	12	9	1	2	3	2	3	0	0	2	4	2	4	0	3	2	3	0	3	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:108308177G>C	uc003dxb.3	-	1	315	c.46C>G	c.(46-48)CAG>GAG	p.Q16E	DZIP3_uc003dxd.2_5'Flank|KIAA1524_uc010hpw.1_5'UTR|DZIP3_uc003dxe.1_5'Flank	NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	16						cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						GCTTTGTACTGACTGACAGTC	0.627													3	49					0	0	0	0	C	108308177	C	C	108308177	3	2	72	1	0	0	0	0	1	0	0	0	8278	1299	45	2	2755	2	KIAA1524	3	108308177	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	3039149	108308177	89714253	39	14741											
POPDC2	64091	broad.mit.edu	37	chr3	119367224	119367224	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagagaggtgggtgtggcctGaggaggggacacagctggct	8	6	21	6	0	0	2	0	1	0	1	0	6	0	4	1	7	1	2	1	7	0	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:119367224G>C	uc003ecx.1	-	3	1026	c.892C>G	c.(892-894)CAG>GAG	p.Q298E	POPDC2_uc010hqw.1_Missense_Mutation_p.Q298E|POPDC2_uc003ecy.1_Missense_Mutation_p.Q116E	NM_022135	NP_071418	Q9HBU9	POPD2_HUMAN	popeye protein 2	298						integral to membrane				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.242)		GGTGTGGCCTGAGGAGGGGAC	0.612													11	94					0	0	0	0	C	119367224	C	C	119367224	3	2	72	1	0	0	0	0	1	0	0	0	12310	1299	45	2	210	2	POPDC2	3	119367224	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	11059047	119367224	78655206	40	14742											
PLXND1	23129	broad.mit.edu	37	chr3	129290406	129290406	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gacacattctgcaccatgtgGaaacgctcaccagccactgt	11	8	8	14	1	2	0	1	0	1	0	2	2	2	1	3	1	3	2	3	1	1	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:129290406G>A	uc003emx.2	-	17	3382	c.3282C>T	c.(3280-3282)TTC>TTT	p.F1094F		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1094	Extracellular (Potential).|IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						GCACCATGTGGAAACGCTCAC	0.662													17	82					0	0	0	0	A	129290406	A	A	129290406	2	1	72	1	0	0	0	0	0	0	0	1	12182	1165	41	2		2	PLXND1	3	129290406	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	9923182	129290406	68732024	41	14743											
TMCC1	23023	broad.mit.edu	37	chr3	129389275	129389276	+	Missense_Mutation	DNP	CG	AA	AA																															ctagtctggcctgggtttccCggatctcctggatctcatgt																										TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:129389275_129389276CG>AA	uc003emz.3	-	5	1909_1910	c.1408_1409CG>TT	c.(1408-1410)CGG>TTG	p.R470L	TMCC1_uc003emy.3_Missense_Mutation_p.R146L|TMCC1_uc011blc.1_Missense_Mutation_p.R291L|TMCC1_uc010htg.2_Missense_Mutation_p.R356L	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	470	Potential.					integral to membrane				skin(1)	1						CTGGGTTTCCCGGATCTCCTGG	0.49													29	140					0	0	0	0	AA	129389276	AA	AA	129389275	3	1	72	1	0	0	0	0	1	0	0	0	16058	652	23	3	564	3	TMCC1	3	129389275	Missense_Mutation	DNP	CG	TCGA-CN-6013-01A-11D-1683-08	98869	129389275	68633155	42	14744											
CPNE4	131034	broad.mit.edu	37	chr3	131300471	131300471	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagttcttgtaattcttcttCttggctttgtacttgggatt	5	21	9	6	0	4	0	0	0	4	0	4	2	4	1	0	2	1	4	0	2	2	11			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:131300471C>T	uc003eok.2	-	9	1254	c.819G>A	c.(817-819)AAG>AAA	p.K273K	CPNE4_uc011blq.1_Silent_p.K291K|CPNE4_uc003eol.2_Silent_p.K291K|CPNE4_uc003eom.2_Silent_p.K273K	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	273										upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AATTCTTCTTCTTGGCTTTGT	0.448													11	81					0	0	0	0	T	131300471	T	T	131300471	2	4	72	1	0	0	0	0	0	0	0	1	3829	912	32	2		2	CPNE4	3	131300471	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	1911196	131300471	66721959	43	14745											
CLSTN2	64084	broad.mit.edu	37	chr3	140284985	140284985	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagctccagcagtggctctGacgacagcgaagaggaggag	11	5	16	9	2	1	3	0	2	1	1	2	7	2	5	1	3	3	3	1	3	1	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:140284985G>A	uc003etn.2	+	17	2948	c.2758G>A	c.(2758-2760)GAC>AAC	p.D920N		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	920	Glu-rich (highly acidic).|Cytoplasmic (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CAGTGGCTCTGACGACAGCGA	0.572										HNSCC(16;0.037)			22	13					0	0	0	0	A	140284985	A	A	140284985	3	1	72	1	0	0	0	0	1	0	0	0	3577	1290	45	2	2824	2	CLSTN2	3	140284985	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	8984514	140284985	57737445	44	14746											
PLSCR4	57088	broad.mit.edu	37	chr3	145917778	145917778	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caatgtaaaccatctggtctGagttgtttttaatatcatat	12	17	6	6	0	3	1	1	1	2	0	3	1	3	1	1	1	1	3	1	1	6	7			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:145917778G>A	uc010huy.2	-	6	775	c.446C>T	c.(445-447)TCA>TTA	p.S149L	PLSCR4_uc010huz.2_Missense_Mutation_p.S149L|PLSCR4_uc003evt.3_Missense_Mutation_p.S149L|PLSCR4_uc010hva.2_Intron|PLSCR4_uc003evu.3_Intron	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	149	Cytoplasmic (By similarity).			S -> L (in Ref. 6; AAP97186).	blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						CATCTGGTCTGAGTTGTTTTT	0.358													11	50					0	0	0	0	A	145917778	A	A	145917778	3	1	72	1	0	0	0	0	1	0	0	0	12167	1294	45	2	559	2	PLSCR4	3	145917778	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	5632793	145917778	52104652	45	14747											
IGSF10	285313	broad.mit.edu	37	chr3	151167020	151167020	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggacactgctgagcactaGagggacttctatcttttttg	8	14	11	8	0	2	2	0	1	2	1	2	4	2	4	0	2	2	2	0	2	2	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:151167020G>C	uc011bod.1	-	4	749	c.749C>G	c.(748-750)TCT>TGT	p.S250C		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	250	LRRCT.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTGAGCACTAGAGGGACTTCT	0.408													15	109					0	0	0	0	C	151167020	C	C	151167020	3	2	72	1	0	0	0	0	1	0	0	0	7636	942	33	2	7182	2	IGSF10	3	151167020	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	5249242	151167020	46855410	46	14748											
GOLIM4	27333	broad.mit.edu	37	chr3	167742328	167742328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactacctcctcttctgcctCttcctggtactgttcatcaa	6	16	4	15	0	5	0	2	0	3	0	7	0	7	0	4	1	4	2	4	1	4	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:167742328C>T	uc003ffe.2	-	14	2190	c.1846G>A	c.(1846-1848)GAG>AAG	p.E616K	GOLIM4_uc011bpe.1_Missense_Mutation_p.E617K|GOLIM4_uc011bpf.1_Missense_Mutation_p.E589K|GOLIM4_uc011bpg.1_Missense_Mutation_p.E588K	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	616	Glu-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						TCTTCTGCCTCTTCCTGGTAC	0.443													4	89					0	0	0	0	T	167742328	T	T	167742328	3	4	72	1	0	0	0	0	1	0	0	0	6603	922	32	2	256	2	GOLIM4	3	167742328	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	16575308	167742328	30280102	47	14749											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	80					0	0	0	0	A	178936082	A	A	178936082	3	1	72	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	11193754	178936082	19086348	48	14750											
CHRD	8646	broad.mit.edu	37	chr3	184104641	184104641	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctctctgcagagacgaacGgtgatctgtgacccggtggt	7	10	13	11	3	2	3	0	2	2	1	4	5	3	3	2	3	2	1	2	3	1	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:184104641G>A	uc003fov.2	+	17	2451	c.2205G>A	c.(2203-2205)ACG>ACA	p.T735T	CHRD_uc003fow.2_Silent_p.T365T|CHRD_uc003fox.2_Silent_p.T735T|CHRD_uc003foy.2_Silent_p.T365T|CHRD_uc010hyc.2_Silent_p.T325T|CHRD_uc011brr.1_Silent_p.T277T	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	735	VWFC 2.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGAGACGAACGGTGATCTGTG	0.657													12	55					0	0	0	0	A	184104641	A	A	184104641	2	1	72	1	0	0	0	0	0	0	0	1	3387	1103	39	1		1	CHRD	3	184104641	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	5168559	184104641	13917789	49	14751											
ACAP2	23527	broad.mit.edu	37	chr3	195028031	195028031	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcaaagcctgaggtcttCaactaccacagtcggattat	11	11	9	10	1	2	1	1	1	1	0	3	2	2	2	2	2	4	1	2	2	4	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:195028031C>A	uc003fun.3	-	12	1172	c.931G>T	c.(931-933)GAA>TAA	p.E311*		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	311	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						CTGAGGTCTTCAACTACCACA	0.368													4	165					0.00909568	0.00950075	1	0	A	195028031	A	A	195028031	4	1	72	1	0	0	0	0	0	1	0	0	119	835	29	2	1453	2	ACAP2	3	195028031	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	10923390	195028031	2994399	50	14752											
IQCG	84223	broad.mit.edu	37	chr3	197659136	197659136	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agtggccgaatcttgcaactCcttaatggtatctgcaatca	11	12	8	10	1	3	0	1	0	2	0	4	1	4	0	2	2	3	3	2	2	5	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr3:197659136C>G	uc003fyo.2	-	5	699	c.553G>C	c.(553-555)GAG>CAG	p.E185Q	IQCG_uc003fyn.2_Missense_Mutation_p.E87Q|IQCG_uc003fyp.2_Missense_Mutation_p.E185Q|IQCG_uc003fyq.3_Missense_Mutation_p.E185Q	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	185											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		TCTTGCAACTCCTTAATGGTA	0.368													16	121					0	0	0	0	G	197659136	G	G	197659136	3	3	72	1	0	0	0	0	1	0	0	0	7849	864	30	2	806	2	IQCG	3	197659136	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	2631105	197659136	363294	51	14753											
NHEDC1	150159	broad.mit.edu	37	chr4	103822391	103822391	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatttggagctgtgatcaaGatggctaaaaatgctactgt	12	12	10	7	0	1	2	1	1	0	1	1	3	1	3	1	2	3	3	1	2	5	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr4:103822391G>C	uc003hww.2	-	12	1553	c.1431C>G	c.(1429-1431)ATC>ATG	p.I477M	NHEDC1_uc003hwu.2_Intron|NHEDC1_uc010ilm.2_Intron|NHEDC1_uc003hwv.2_Intron|NHEDC1_uc011cev.1_Missense_Mutation_p.I250M	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	477	Helical; (Potential).					integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		CTGTGATCAAGATGGCTAAAA	0.458													15	214					0	0	0	0	C	103822391	C	C	103822391	3	2	72	1	0	0	0	0	1	0	0	0	10454	932	33	2	220	2	NHEDC1	4	103822391	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08		103822391	87331885	52	14754											
KIAA1109	84162	broad.mit.edu	37	chr4	123252691	123252691	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaacatgatgatataagtttGagaaggtaagaaattgattg	17	12	11	1	0	0	5	0	4	0	2	0	7	0	5	0	1	1	2	0	1	6	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr4:123252691G>C	uc003ieh.2	+	65	11505	c.11460G>C	c.(11458-11460)TTG>TTC	p.L3820F	KIAA1109_uc003iem.2_Missense_Mutation_p.L211F	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3820					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						ATATAAGTTTGAGAAGGTAAG	0.313													4	26					0	0	0	0	C	123252691	C	C	123252691	3	2	72	1	0	0	0	0	1	0	0	0	8247	1281	45	2	11718	2	KIAA1109	4	123252691	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	19430300	123252691	67901585	53	14755											
NEK1	4750	broad.mit.edu	37	chr4	170400665	170400665	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtggagaaacatcagaactCttaactcctttagccaccaa	14	9	7	11	0	2	2	1	0	1	2	3	3	3	2	3	2	4	0	3	2	5	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr4:170400665C>G	uc003isb.1	-	22	2436	c.1944G>C	c.(1942-1944)AAG>AAC	p.K648N	NEK1_uc003isc.1_Missense_Mutation_p.K604N|NEK1_uc003isd.1_Missense_Mutation_p.K676N|NEK1_uc003ise.1_Missense_Mutation_p.K632N|NEK1_uc003isf.1_Missense_Mutation_p.K579N	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	648					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		CATCAGAACTCTTAACTCCTT	0.348													8	42					0	0	0	0	G	170400665	G	G	170400665	3	3	72	1	0	0	0	0	1	0	0	0	10375	912	32	2	1884	2	NEK1	4	170400665	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	47147974	170400665	20753611	54	14756											
CLCN3	1182	broad.mit.edu	37	chr4	170628303	170628303	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggacaatatgacagtggatGatatagaaaacatgattaat	19	10	9	3	0	0	4	0	3	0	1	0	6	0	6	0	2	1	0	0	2	7	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr4:170628303G>A	uc003isi.2	+	11	2544	c.2035G>A	c.(2035-2037)GAT>AAT	p.D679N	CLCN3_uc003ish.2_Missense_Mutation_p.D679N|CLCN3_uc011cjz.1_Missense_Mutation_p.D662N|CLCN3_uc011cka.1_Missense_Mutation_p.D652N|CLCN3_uc003isj.1_Missense_Mutation_p.D652N	NM_001829	NP_001820	P51790	CLCN3_HUMAN	chloride channel 3 isoform b	679	CBS 1.|Cytoplasmic (By similarity).				endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(2)|ovary(1)	3		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		GACAGTGGATGATATAGAAAA	0.423													27	92					0	0	0	0	A	170628303	A	A	170628303	3	1	72	1	0	0	0	0	1	0	0	0	3479	1290	45	2	2073	2	CLCN3	4	170628303	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	227638	170628303	20525973	55	14757											
RPL37	6167	broad.mit.edu	37	chr5	40834692	40834693	+	Missense_Mutation	DNP	GA	TT	TT																															tattgcgacgctttccaaacGatgacgttcccttcgtctgc																										TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr5:40834692_40834693GA>TT	uc003jme.1	-	2	119_120	c.19_20TC>AA	c.(19-21)TCG>AAG	p.S7K	SNORD72_uc003jmf.1_5'Flank	NM_000997	NP_000988	P61927	RL37_HUMAN	ribosomal protein L37	7					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	metal ion binding|protein binding|rRNA binding|structural constituent of ribosome				0		Breast(839;0.238)				CTTTCCAAACGATGACGTTCCC	0.475													19	23					0	0	0	0	TT	40834693	TT	TT	40834692	3	4	72	1	0	0	0	0	1	0	0	0	13654	1059	37	3	285	3	RPL37	5	40834692	Missense_Mutation	DNP	GA	TCGA-CN-6013-01A-11D-1683-08		40834692	140080568	56	14758											
ADAMTS6	11174	broad.mit.edu	37	chr5	64483990	64483990	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatgcagagcactgccctTgtgcgcatcccaccatcaca	9	8	8	16	1	1	2	1	1	0	1	2	2	2	2	3	0	4	3	3	0	0	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr5:64483990T>C	uc003jtp.2	-	22	3577	c.2763A>G	c.(2761-2763)ACA>ACG	p.T921T	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	921	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		GCACTGCCCTTGTGCGCATCC	0.517													33	97					0	0	0	0	C	64483990	C	C	64483990	2	2	72	1	0	0	0	0	0	0	0	1	270	1799	63	5		5	ADAMTS6	5	64483990	Silent	SNP	T	TCGA-CN-6013-01A-11D-1683-08	23649298	64483990	116431270	57	14759											
VCAN	1462	broad.mit.edu	37	chr5	82833070	82833070	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacataaatgggaagcatctCgttaccactgtgcccaagga	13	9	9	10	1	1	0	0	0	1	0	2	2	1	2	2	2	4	2	2	2	6	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr5:82833070C>T	uc003kii.3	+	8	4604	c.4248C>T	c.(4246-4248)CTC>CTT	p.L1416L	VCAN_uc003kij.3_Silent_p.L429L|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Silent_p.L80L	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1416	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GGAAGCATCTCGTTACCACTG	0.428													17	27					0	0	0	0	T	82833070	T	T	82833070	2	4	72	1	0	0	0	0	0	0	0	1	17206	871	31	1		1	VCAN	5	82833070	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	18349080	82833070	98082190	58	14760											
HSPA9	3313	broad.mit.edu	37	chr5	137906699	137906699	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgccggccaatgagacgcttGgtagcataaaatgtattgtt	11	11	11	8	3	0	1	0	1	0	1	0	2	0	1	2	2	1	5	2	2	5	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr5:137906699G>A	uc003ldf.2	-	4	468	c.360C>T	c.(358-360)ACC>ACT	p.T120T	HSPA9_uc011cyw.1_Silent_p.T51T	NM_004134	NP_004125	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 precursor	120					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGAGACGCTTGGTAGCATAAA	0.468													24	68					0	0	0	0	A	137906699	A	A	137906699	2	1	72	1	0	0	0	0	0	0	0	1	7456	1335	47	4		4	HSPA9	5	137906699	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	55073629	137906699	43008561	59	14761											
PCDHGB5	56101	broad.mit.edu	37	chr5	140779900	140779900	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcaagtctggacctgtggttCcccccaactacagtcagggg	8	9	11	13	0	3	0	2	0	1	0	4	1	4	1	4	4	2	1	4	4	3	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr5:140779900C>A	uc003lkf.1	+	1	2206	c.2206C>A	c.(2206-2208)CCC>ACC	p.P736T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.P736T|PCDHGA9_uc011dax.1_5'Flank|PCDHGA9_uc003lkh.1_5'Flank	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	736	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTGTGGTTCCCCCCAACTA	0.527													43	167					6.57855e-14	7.10153e-14	1	0	A	140779900	A	A	140779900	3	1	72	1	0	0	0	0	1	0	0	0	11620	855	30	2	2208	2	PCDHGB5	5	140779900	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	2873201	140779900	40135360	60	14762											
PCDHGB6	56100	broad.mit.edu	37	chr5	140788504	140788504	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccggttttcagcagagaCgaatatagaattagtcttag	12	11	9	9	2	2	2	1	0	1	2	2	4	2	2	2	1	1	2	2	1	6	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr5:140788504C>T	uc003lkj.1	+	1	735	c.735C>T	c.(733-735)GAC>GAT	p.D245D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.D245D	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	245	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGCAGAGACGAATATAGAA	0.502													3	14					0	0	0	0	T	140788504	T	T	140788504	2	4	72	1	0	0	0	0	0	0	0	1	11621	535	19	1		1	PCDHGB6	5	140788504	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	8604	140788504	40126756	61	14763											
ZNF300	91975	broad.mit.edu	37	chr5	150277669	150277669	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctggatagatccaatttgAtatgtctccctttatgatcc	10	16	6	9	0	2	3	0	2	2	1	5	4	4	4	3	1	0	0	3	1	4	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr5:150277669A>G	uc003lsy.1	-	5	487	c.220T>C	c.(220-222)TCA>CCA	p.S74P	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	74	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCCAATTTGATATGTCTCCC	0.378													19	60					0	0	0	0	G	150277669	G	G	150277669	3	3	72	1	0	0	0	0	1	0	0	0	17898	333	12	5	1602	5	ZNF300	5	150277669	Missense_Mutation	SNP	A	TCGA-CN-6013-01A-11D-1683-08	9489165	150277669	30637591	62	14764											
KCNMB1	3779	broad.mit.edu	37	chr5	169812329	169812329	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcagtaccttttctggtaGaggggcagcacagtcgtgac	8	10	13	10	1	2	2	1	1	1	1	3	2	2	2	1	3	2	5	1	3	2	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr5:169812329G>A	uc003maq.1	-	2	523	c.123C>T	c.(121-123)CTC>CTT	p.L41L	KCNIP1_uc003map.2_Intron|KCNMB1_uc003mar.2_Silent_p.L41L	NM_004137	NP_004128	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated	41	Extracellular (Potential).				platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			ovary(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		TTTTCTGGTAGAGGGGCAGCA	0.597													24	68					0	0	0	0	A	169812329	A	A	169812329	2	1	72	1	0	0	0	0	0	0	0	1	8113	929	33	2		2	KCNMB1	5	169812329	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	19534660	169812329	11102931	63	14765											
ADAMTS2	9509	broad.mit.edu	37	chr5	178557035	178557035	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccatggcaatgaaggttttGgaactggcatccacgtcatt	10	11	10	10	1	1	1	1	1	0	0	2	2	2	2	2	4	1	3	2	4	3	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr5:178557035G>A	uc003mjw.2	-	16	2355	c.2355C>T	c.(2353-2355)TCC>TCT	p.S785S		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	785	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TGAAGGTTTTGGAACTGGCAT	0.567													15	38					0	0	0	0	A	178557035	A	A	178557035	2	1	72	1	0	0	0	0	0	0	0	1	265	1335	47	4		4	ADAMTS2	5	178557035	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	8744706	178557035	2358225	64	14766											
HIST1H2AK	8330	broad.mit.edu	37	chr6	27805967	27805968	+	Missense_Mutation	DNP	AC	TA	TA																															ctccaacaccgccgccaggtAcaccggcgctccggcaccga																										TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:27805967_27805968AC>TA	uc003njs.2	-	1	150_151	c.150_151GT>TA	c.(148-153)GTGTAC>GTTAAC	p.Y51N	HIST1H2BN_uc003njt.1_5'Flank|HIST1H2BN_uc003nju.1_5'Flank|HIST1H2BN_uc003njv.2_5'Flank	NM_003510	NP_003501	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	51					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			upper_aerodigestive_tract(1)	1						GCCGCCAGGTACACCGGCGCTC	0.658													7	52					0	0	0	0	TA	27805968	TA	TA	27805967	3	4	72	1	0	0	0	0	1	0	0	0	7176	391	14	5	245	5	HIST1H2AK	6	27805967	Missense_Mutation	DNP	AC	TCGA-CN-6013-01A-11D-1683-08		27805967	143309100	65	14767											
HIST1H2AM	8336	broad.mit.edu	37	chr6	27860925	27860925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgcttgccacgtccagaCatggtaaaacgacctgtggc	9	8	10	14	2	0	1	0	0	0	1	1	2	1	1	4	2	3	2	4	2	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:27860925C>T	uc003nkb.1	-	1	39	c.3G>A	c.(1-3)ATG>ATA	p.M1I	HIST1H3J_uc003nka.2_5'Flank|HIST1H2BO_uc003nkc.1_5'Flank	NM_003514	NP_003505	P0C0S8	H2A1_HUMAN	histone cluster 1, H2am	1					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding	p.M1V(1)		ovary(2)	2						CACGTCCAGACATGGTAAAAC	0.577													23	20					0	0	0	0	T	27860925	T	T	27860925	3	4	72	1	0	0	0	0	1	0	0	0	7178	478	17	4	393	4	HIST1H2AM	6	27860925	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	54958	27860925	143254142	66	14768											
VARS	7407	broad.mit.edu	37	chr6	31749637	31749637	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccttgccttgctggagactGatcttgtcaggggacactcc	6	11	12	12	0	2	2	1	1	1	1	3	4	3	3	3	3	2	1	3	3	0	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:31749637G>A	uc003nxe.2	-	19	2757	c.2334C>T	c.(2332-2334)ATC>ATT	p.I778I	VARS_uc003nxf.1_5'Flank|VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	778					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GCTGGAGACTGATCTTGTCAG	0.622													7	217					0	0	0	0	A	31749637	A	A	31749637	2	1	72	1	0	0	0	0	0	0	0	1	17191	1280	45	2		2	VARS	6	31749637	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	3888712	31749637	139365430	67	14769											
KIF6	221458	broad.mit.edu	37	chr6	39513400	39513400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaactttacgcatatccgCgccaacctctaatctactgt	11	12	5	13	3	2	1	0	1	2	0	3	1	3	1	3	0	4	1	3	0	6	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:39513400C>T	uc003oot.2	-	11	1341	c.1246G>A	c.(1246-1248)GCG>ACG	p.A416T	KIF6_uc010jxa.1_Missense_Mutation_p.A207T|KIF6_uc011dua.1_Missense_Mutation_p.A416T|KIF6_uc010jxb.1_Missense_Mutation_p.A416T	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	416					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						CGCATATCCGCGCCAACCTCT	0.368													33	52					0	0	0	0	T	39513400	T	T	39513400	3	4	72	1	0	0	0	0	1	0	0	0	8347	768	27	1	1250	1	KIF6	6	39513400	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	7763763	39513400	131601667	68	14770											
EYS	346007	broad.mit.edu	37	chr6	66204797	66204797	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctggcagaactgctgtttCactgtcacatttagtcgaag	9	13	9	10	1	2	1	2	0	0	1	4	2	3	1	1	1	2	3	1	1	3	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:66204797C>T	uc011dxu.1	-	4	1045	c.507G>A	c.(505-507)GTG>GTA	p.V169V	EYS_uc003peq.2_Silent_p.V169V|EYS_uc003per.1_Silent_p.V169V|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	169					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						ACTGCTGTTTCACTGTCACAT	0.433													11	30					0	0	0	0	T	66204797	T	T	66204797	2	4	72	1	0	0	0	0	0	0	0	1	5357	813	29	2		2	EYS	6	66204797	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	26691397	66204797	104910270	69	14771											
DOPEY1	23033	broad.mit.edu	37	chr6	83818774	83818774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtattcttcctggcttaGaagaaggatcagagtactat	11	13	10	7	0	2	3	1	0	1	3	3	4	3	4	1	3	1	3	1	3	6	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:83818774G>A	uc003pjs.1	+	5	726	c.466G>A	c.(466-468)GAA>AAA	p.E156K	DOPEY1_uc011dyy.1_Missense_Mutation_p.E156K|DOPEY1_uc010kbl.1_Missense_Mutation_p.E156K	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	156					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TCCTGGCTTAGAAGAAGGATC	0.373													23	73					0	0	0	0	A	83818774	A	A	83818774	3	1	72	1	0	0	0	0	1	0	0	0	4729	943	33	2	476	2	DOPEY1	6	83818774	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	17613977	83818774	87296293	70	14772											
DOPEY1	23033	broad.mit.edu	37	chr6	83847361	83847361	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attaaaattgaagatgactcCattcaacagagtcagaatgc	17	10	7	7	0	2	5	2	2	0	3	3	5	3	5	1	0	2	0	1	0	5	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:83847361C>T	uc003pjs.1	+	21	3860	c.3600C>T	c.(3598-3600)TCC>TCT	p.S1200S	DOPEY1_uc011dyy.1_Silent_p.S1191S|DOPEY1_uc010kbl.1_Silent_p.S1191S|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1200					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAGATGACTCCATTCAACAGA	0.413													10	30					0	0	0	0	T	83847361	T	T	83847361	2	4	72	1	0	0	0	0	0	0	0	1	4729	581	21	4		4	DOPEY1	6	83847361	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	28587	83847361	87267706	71	14773											
C6orf165	154313	broad.mit.edu	37	chr6	88173822	88173822	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	attgttcccaagtgtaccctCcaaaggacactagcacccag	12	8	7	14	0	0	0	0	0	0	0	2	1	2	1	4	1	2	3	4	1	4	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:88173822C>G	uc003plv.2	+	13	1815	c.1723C>G	c.(1723-1725)CCA>GCA	p.P575A	SLC35A1_uc003plx.2_RNA|C6orf165_uc003plw.2_Missense_Mutation_p.P387A|C6orf165_uc010kbv.1_RNA	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	575										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGTGTACCCTCCAAAGGACAC	0.473													9	30					0	0	0	0	G	88173822	G	G	88173822	3	3	72	1	0	0	0	0	1	0	0	0	2351	855	30	2	1769	2	C6orf165	6	88173822	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	4326461	88173822	82941245	72	14774											
EPHA7	2045	broad.mit.edu	37	chr6	93979222	93979222	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattttacctgtagcttcctCtagtgtagcaacatcaagtc	10	14	6	11	0	2	0	1	0	1	0	4	0	3	0	2	0	4	4	2	0	6	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:93979222C>T	uc003poe.2	-	7	1847	c.1606G>A	c.(1606-1608)GAG>AAG	p.E536K	EPHA7_uc003pof.2_Missense_Mutation_p.E536K|EPHA7_uc011eac.1_Missense_Mutation_p.E536K	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	536	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GTAGCTTCCTCTAGTGTAGCA	0.353													14	62					0	0	0	0	T	93979222	T	T	93979222	3	4	72	1	0	0	0	0	1	0	0	0	5196	922	32	2	1434	2	EPHA7	6	93979222	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	5805400	93979222	77135845	73	14775											
AIM1	202	broad.mit.edu	37	chr6	106973169	106973169	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatatagtgaacccgacgtCtctgagaagtgcattgaagt	13	11	10	7	2	1	3	0	3	1	1	2	5	1	3	1	0	2	1	1	0	6	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:106973169C>T	uc003prh.2	+	4	3583	c.3096C>T	c.(3094-3096)GTC>GTT	p.V1032V		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1032	Beta/gamma crystallin 'Greek key' 1.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AACCCGACGTCTCTGAGAAGT	0.403													31	145					0	0	0	0	T	106973169	T	T	106973169	2	4	72	1	0	0	0	0	0	0	0	1	430	900	32	2		2	AIM1	6	106973169	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	12993947	106973169	64141898	74	14776											
RSPH4A	345895	broad.mit.edu	37	chr6	116937941	116937941	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaagcaggggccagaaactgGacgccagtcccgaagcagcc	12	2	14	13	2	0	1	0	0	0	1	1	4	1	2	4	3	4	2	4	3	3	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:116937941G>A	uc003pxe.2	+	1	300	c.155G>A	c.(154-156)GGA>GAA	p.G52E	RSPH4A_uc010kee.2_Missense_Mutation_p.G52E	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	52					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						CCAGAAACTGGACGCCAGTCC	0.612									Kartagener_syndrome				5	27					0	0	0	0	A	116937941	A	A	116937941	3	1	72	1	0	0	0	0	1	0	0	0	13771	1174	41	2	157	2	RSPH4A	6	116937941	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	9964772	116937941	54177126	75	14777											
SYNE1	23345	broad.mit.edu	37	chr6	152510447	152510447	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgcgttcattaagaatggaGatatcatcagcactgatata	15	11	8	7	2	3	3	3	1	0	2	3	4	3	3	0	1	1	2	0	1	5	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:152510447G>A	uc010kiw.2	-	128	23843	c.23241C>T	c.(23239-23241)ATC>ATT	p.I7747I	SYNE1_uc010kiv.2_Silent_p.I2271I|SYNE1_uc003qos.3_Silent_p.I2271I|SYNE1_uc003qot.3_Silent_p.I7676I|SYNE1_uc003qou.3_Silent_p.I7747I|SYNE1_uc003qoq.3_5'UTR|SYNE1_uc003qor.3_Silent_p.I647I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7747	Cytoplasmic (Potential).|Spectrin 26.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TAAGAATGGAGATATCATCAG	0.433										HNSCC(10;0.0054)			15	80					0	0	0	0	A	152510447	A	A	152510447	2	1	72	1	0	0	0	0	0	0	0	1	15511	932	33	2		2	SYNE1	6	152510447	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	35572506	152510447	18604620	76	14778											
SYNE1	23345	broad.mit.edu	37	chr6	152776622	152776622	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggccctcctgagcaatcCgcagtaccttctccaactct	8	9	6	18	1	2	1	0	1	2	0	5	1	4	1	6	1	3	3	6	1	3	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:152776622C>T	uc010kiw.2	-	24	3433	c.2831G>A	c.(2830-2832)CGG>CAG	p.R944Q	SYNE1_uc003qot.3_Missense_Mutation_p.R951Q|SYNE1_uc003qou.3_Missense_Mutation_p.R944Q|SYNE1_uc010kjb.1_Missense_Mutation_p.R927Q|SYNE1_uc003qow.2_Missense_Mutation_p.R239Q|SYNE1_uc003qox.1_Missense_Mutation_p.R460Q|SYNE1_uc003qoz.2_Missense_Mutation_p.R376Q|SYNE1_uc003qoy.2_Missense_Mutation_p.R511Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	944	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGAGCAATCCGCAGTACCTT	0.507										HNSCC(10;0.0054)			4	73					0	0	0	0	T	152776622	T	T	152776622	3	4	72	1	0	0	0	0	1	0	0	0	15511	652	23	1	24127	1	SYNE1	6	152776622	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	266175	152776622	18338445	77	14779											
RPS6KA2	6196	broad.mit.edu	37	chr6	166944772	166944772	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgtagagctgcccagcgtcGgaccccttcaccttcctcac	6	8	9	18	3	2	1	2	0	0	1	4	2	3	2	5	1	3	2	5	1	1	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr6:166944772G>A	uc003qvb.1	-	3	465	c.246C>T	c.(244-246)TCC>TCT	p.S82S	RPS6KA2_uc011ego.1_5'UTR|RPS6KA2_uc010kkl.1_5'UTR|RPS6KA2_uc003qvc.1_Silent_p.S90S|RPS6KA2_uc003qvd.1_Silent_p.S107S	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	82	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GCCCAGCGTCGGACCCCTTCA	0.498													23	66					0	0	0	0	A	166944772	A	A	166944772	2	1	72	1	0	0	0	0	0	0	0	1	13716	1103	39	1		1	RPS6KA2	6	166944772	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	14168150	166944772	4170295	78	14780											
ZNF12	7559	broad.mit.edu	37	chr7	6731675	6731675	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaggatttcccacactgatTacattcgtaaggtttctctc	10	14	7	10	1	1	1	0	1	1	0	5	3	2	2	1	2	1	2	1	2	3	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:6731675T>A	uc003sqt.1	-	5	1452	c.898A>T	c.(898-900)AAT>TAT	p.N300Y	ZNF12_uc011jxa.1_Missense_Mutation_p.N138Y|ZNF12_uc003sqs.1_Missense_Mutation_p.N262Y	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	300	C2H2-type 2.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		CCACACTGATTACATTCGTAA	0.423													10	60					0	0	0	0	A	6731675	A	A	6731675	3	1	72	1	0	0	0	0	1	0	0	0	17785	1754	61	5	1199	5	ZNF12	7	6731675	Missense_Mutation	SNP	T	TCGA-CN-6013-01A-11D-1683-08		6731675	152406988	79	14781											
ZNF12	7559	broad.mit.edu	37	chr7	6731957	6731957	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatacgaattttctgataaaGactttcttcatttagagtat	14	17	5	5	1	3	3	1	1	2	2	3	4	3	3	0	0	1	1	0	0	7	9			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:6731957G>C	uc003sqt.1	-	5	1170	c.616C>G	c.(616-618)CTT>GTT	p.L206V	ZNF12_uc011jxa.1_Missense_Mutation_p.L44V|ZNF12_uc003sqs.1_Missense_Mutation_p.L168V	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	206					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TTCTGATAAAGACTTTCTTCA	0.328													6	26					0	0	0	0	C	6731957	C	C	6731957	3	2	72	1	0	0	0	0	1	0	0	0	17785	942	33	2	1481	2	ZNF12	7	6731957	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	282	6731957	152406706	80	14782											
RFC2	5982	broad.mit.edu	37	chr7	73663387	73663387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatggcatctttgagtgctGggcccagcagggcccgggcc	6	7	15	13	1	1	1	0	1	1	0	1	1	1	1	3	4	2	3	3	4	0	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:73663387G>A	uc003uaj.2	-	4	312	c.287C>T	c.(286-288)CCA>CTA	p.P96L	RFC2_uc011kfa.1_RNA|RFC2_uc003uak.2_Missense_Mutation_p.P96L|RFC2_uc010lbp.2_Missense_Mutation_p.P59L|RFC2_uc003ual.2_5'UTR	NM_181471	NP_852136	P35250	RFC2_HUMAN	replication factor C 2 isoform 1	96					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			liver(1)|central_nervous_system(1)	2						TTTGAGTGCTGGGCCCAGCAG	0.542													25	106					0	0	0	0	A	73663387	A	A	73663387	3	1	72	1	0	0	0	0	1	0	0	0	13310	1348	47	4	809	4	RFC2	7	73663387	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	66931430	73663387	85475276	81	14783											
SEMA3E	9723	broad.mit.edu	37	chr7	83029401	83029401	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcttccactcgatctactgCtatttgtttcaggttatatt	8	18	6	9	1	2	0	1	0	1	0	4	1	3	0	1	1	3	4	1	1	4	8			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:83029401C>A	uc003uhy.1	-	11	1775	c.1309G>T	c.(1309-1311)GCA>TCA	p.A437S		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	437	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				CGATCTACTGCTATTTGTTTC	0.378													26	123					1.77063e-15	1.92752e-15	1	0	A	83029401	A	A	83029401	3	1	72	1	0	0	0	0	1	0	0	0	14093	797	28	4	1046	4	SEMA3E	7	83029401	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	9366014	83029401	76109262	82	14784											
TRRAP	8295	broad.mit.edu	37	chr7	98601841	98601841	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagcgttccaggatccatGaagcttcataatcttatttc	10	15	6	10	1	3	1	2	1	1	0	6	2	5	2	2	1	2	2	2	1	3	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:98601841G>A	uc003upp.2	+	67	10505	c.10296G>A	c.(10294-10296)ATG>ATA	p.M3432I	TRRAP_uc011kis.1_Missense_Mutation_p.M3403I|TRRAP_uc003upr.2_Missense_Mutation_p.M3138I	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3432					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CAGGATCCATGAAGCTTCATA	0.378													25	153					0	0	0	0	A	98601841	A	A	98601841	3	1	72	1	0	0	0	0	1	0	0	0	16668	1290	45	2	10467	2	TRRAP	7	98601841	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	15572440	98601841	60536822	83	14785											
ZNF498	221785	broad.mit.edu	37	chr7	99219092	99219092	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccagtggaggtcaagcctGaatgggggatgccccctggg	7	6	18	10	0	1	1	1	1	0	0	1	3	1	3	4	6	2	0	4	6	2	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:99219092G>A	uc003url.1	+	5	811	c.484G>A	c.(484-486)GAA>AAA	p.E162K	ZNF498_uc003urm.1_5'UTR|ZNF498_uc010lge.1_5'UTR|ZNF498_uc003urn.2_RNA|ZNF498_uc010lgf.1_Missense_Mutation_p.E162K|ZNF498_uc003uro.1_5'UTR	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	162					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GGTCAAGCCTGAATGGGGGAT	0.617													17	100					0	0	0	0	A	99219092	A	A	99219092	3	1	72	1	0	0	0	0	1	0	0	0	18014	1291	45	2	490	2	ZNF498	7	99219092	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	617251	99219092	59919571	84	14786											
CYP3A7	1551	broad.mit.edu	37	chr7	99305456	99305456	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgtttctttacaaggtttGaaggagaagttctgaaggac	11	14	12	4	0	2	3	0	2	2	1	2	5	2	4	0	3	1	3	0	3	5	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:99305456G>A	uc003uru.2	-	12	1500	c.1395C>T	c.(1393-1395)TTC>TTT	p.F465F	ZNF498_uc003urn.2_RNA|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	465					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TACAAGGTTTGAAGGAGAAGT	0.353													24	184					0	0	0	0	A	99305456	A	A	99305456	2	1	72	1	0	0	0	0	0	0	0	1	4198	1281	45	2		2	CYP3A7	7	99305456	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	86364	99305456	59833207	85	14787											
SLC12A9	56996	broad.mit.edu	37	chr7	100463640	100463640	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggggtctgggggcacctctCagctgcaccatgtggacgtg	5	8	17	11	1	2	0	1	0	2	0	3	1	2	1	2	5	2	3	2	5	0	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:100463640C>T	uc003uwp.2	+	14	2300	c.2158C>T	c.(2158-2160)CAG>TAG	p.Q720*	SLC12A9_uc011kki.1_Nonsense_Mutation_p.Q251*|SLC12A9_uc003uwr.2_Nonsense_Mutation_p.Q456*|SLC12A9_uc003uws.2_Nonsense_Mutation_p.Q251*|SLC12A9_uc003uwt.2_Nonsense_Mutation_p.Q456*|SLC12A9_uc003uwv.2_Nonsense_Mutation_p.Q251*|TRIP6_uc010lhk.1_5'Flank|TRIP6_uc003uww.2_5'Flank	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	720	Extracellular (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGGCACCTCTCAGCTGCACCA	0.692													31	317					0	0	0	0	T	100463640	T	T	100463640	4	4	72	1	0	0	0	0	0	1	0	0	14455	827	29	2	2208	2	SLC12A9	7	100463640	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	1158184	100463640	58675023	86	14788											
DOCK4	9732	broad.mit.edu	37	chr7	111400292	111400292	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggttggcgtgctgcatggcGatggcatgggggaactcgtt	5	11	18	7	3	0	0	0	0	0	0	1	2	0	1	0	6	3	5	0	6	1	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:111400292G>A	uc003vfx.2	-	39	4349	c.4080C>T	c.(4078-4080)ATC>ATT	p.I1360I	DOCK4_uc011kml.1_Silent_p.I241I|DOCK4_uc011kmm.1_Silent_p.I267I|DOCK4_uc003vfw.2_Silent_p.I810I|DOCK4_uc003vfy.2_Silent_p.I1405I	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1360	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				GCTGCATGGCGATGGCATGGG	0.547													27	245					0	0	0	0	A	111400292	A	A	111400292	2	1	72	1	0	0	0	0	0	0	0	1	4711	1048	37	1		1	DOCK4	7	111400292	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	10936652	111400292	47738371	87	14789											
C7orf58	79974	broad.mit.edu	37	chr7	120629789	120629789	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	actctgaccctccgagggtcGaggaagctcacagccgctgc	8	6	12	15	3	2	1	1	1	1	0	4	4	3	2	3	2	3	2	3	2	1	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:120629789G>C	uc003vjq.3	+	2	561	c.114G>C	c.(112-114)TCG>TCC	p.S38S	C7orf58_uc003vjr.1_Silent_p.S38S|C7orf58_uc003vjs.3_Silent_p.S38S	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	38						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TCCGAGGGTCGAGGAAGCTCA	0.572													12	63					0	0	0	0	C	120629789	C	C	120629789	2	2	72	1	0	0	0	0	0	0	0	1	2416	1045	37	3		3	C7orf58	7	120629789	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	9229497	120629789	38508874	88	14790											
KEL	3792	broad.mit.edu	37	chr7	142651327	142651327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccctgtgcccgccgctgctCcaggggcctcagaaactgga	6	6	13	16	2	1	1	1	0	0	1	2	2	2	2	5	3	3	2	5	3	1	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:142651327C>T	uc003wcb.2	-	8	1078	c.868G>A	c.(868-870)GAG>AAG	p.E290K		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	290	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					CGCCGCTGCTCCAGGGGCCTC	0.582													4	30					0	0	0	0	T	142651327	T	T	142651327	3	4	72	1	0	0	0	0	1	0	0	0	8181	864	30	2	1378	2	KEL	7	142651327	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	22021538	142651327	16487336	89	14791											
MLL3	58508	broad.mit.edu	37	chr7	151900145	151900145	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtatctggtaactgctcactCcagcctgaaacaacagtcac	12	9	7	13	0	3	1	2	1	1	0	4	1	4	1	2	1	5	3	2	1	4	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr7:151900145C>T	uc003wla.2	-	26	4185	c.3966G>A	c.(3964-3966)TGG>TGA	p.W1322*	MLL3_uc003wkz.2_Nonsense_Mutation_p.W383*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1322					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACTGCTCACTCCAGCCTGAAA	0.328			N		medulloblastoma								5	17					0	0	0	0	T	151900145	T	T	151900145	4	4	72	1	0	0	0	0	0	1	0	0	9675	856	30	2	10905	2	MLL3	7	151900145	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	9248818	151900145	7238518	90	14792											
RP1	6101	broad.mit.edu	37	chr8	55537230	55537230	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tactcttaaaatctttaaagTaagcacacatatgtcttcaa	16	14	3	8	0	4	0	1	0	3	0	4	0	4	0	0	0	2	2	0	0	8	7			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr8:55537230T>A	uc003xsd.1	+	4	936	c.788T>A	c.(787-789)ATA>AAA	p.I263K	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	263					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATCTTTAAAGTAAGCACACAT	0.333													20	55					0	0	0	0	A	55537230	A	A	55537230	3	1	72	1	0	0	0	0	1	0	0	0	13597	1652	57	5	798	5	RP1	8	55537230	Missense_Mutation	SNP	T	TCGA-CN-6013-01A-11D-1683-08		55537230	90826792	91	14793											
PREX2	80243	broad.mit.edu	37	chr8	68992764	68992764	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agggatcaaatatgaaacatCgacttatgaaacatgactta	18	10	7	6	1	1	3	1	3	0	0	2	5	1	4	0	1	2	0	0	1	6	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr8:68992764C>T	uc003xxv.1	+	16	1756	c.1729C>T	c.(1729-1731)CGA>TGA	p.R577*	PREX2_uc003xxu.1_Nonsense_Mutation_p.R577*|PREX2_uc011lez.1_Nonsense_Mutation_p.R512*	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	577					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TATGAAACATCGACTTATGAA	0.313													3	53					0	0	0	0	T	68992764	T	T	68992764	4	4	72	1	0	0	0	0	0	1	0	0	12539	876	31	1	1791	1	PREX2	8	68992764	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	13455534	68992764	77371258	92	14794											
KCNB2	9312	broad.mit.edu	37	chr8	73849010	73849010	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggctgttgagaaggccggaGagtccgccaacacaaaggac	12	5	14	10	2	0	2	0	1	0	2	1	5	1	3	3	4	1	2	3	4	3	1	rs140088625		TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr8:73849010G>A	uc003xzb.2	+	3	2008	c.1420G>A	c.(1420-1422)GAG>AAG	p.E474K		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	474	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding	p.E474K(1)		skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GAAGGCCGGAGAGTCCGCCAA	0.532													18	110					0	0	0	0	A	73849010	A	A	73849010	3	1	72	1	0	0	0	0	1	0	0	0	8052	943	33	2	1426	2	KCNB2	8	73849010	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	4856246	73849010	72515012	93	14795											
CSMD3	114788	broad.mit.edu	37	chr8	113326672	113326672	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggttaccatcatacacctgaAgaacatcaaattccttttct	13	13	4	11	0	3	2	2	1	1	1	4	2	4	2	3	1	3	1	3	1	5	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr8:113326672A>C	uc003ynu.2	-	48	7694	c.7535T>G	c.(7534-7536)CTT>CGT	p.L2512R	CSMD3_uc003yns.2_Missense_Mutation_p.L1714R|CSMD3_uc003ynt.2_Missense_Mutation_p.L2472R|CSMD3_uc011lhx.1_Missense_Mutation_p.L2408R|CSMD3_uc003ynw.1_Missense_Mutation_p.L223R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2512	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane		p.L2512H(1)		ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATACACCTGAAGAACATCAAA	0.323										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	53					0	0	0	0	C	113326672	C	C	113326672	3	2	72	1	0	0	0	0	1	0	0	0	3963	72	3	5	3684	5	CSMD3	8	113326672	Missense_Mutation	SNP	A	TCGA-CN-6013-01A-11D-1683-08	39477662	113326672	33037350	94	14796											
RAD21	5885	broad.mit.edu	37	chr8	117868438	117868438	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggctccaatgcaaatgcttCttcctcatttggaacaagtg	11	12	8	10	0	2	0	1	0	1	0	4	1	4	1	2	2	3	3	2	2	4	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr8:117868438C>T	uc003yod.2	-	8	1192	c.904G>A	c.(904-906)GAA>AAA	p.E302K		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	302	Interaction with WAPAL and PDS5B.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					GCAAATGCTTCTTCCTCATTT	0.398													14	108					0	0	0	0	T	117868438	T	T	117868438	3	4	72	1	0	0	0	0	1	0	0	0	13046	922	32	2	1019	2	RAD21	8	117868438	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	4541766	117868438	28495584	95	14797											
PTK2	5747	broad.mit.edu	37	chr8	141900645	141900645	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaaaaacgtacttaccctGacatcagtagcatctccatg	13	10	7	11	1	2	1	1	1	1	0	3	2	2	2	2	1	4	3	2	1	5	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr8:141900645G>C	uc003yvu.2	-	3	422	c.192C>G	c.(190-192)GTC>GTG	p.V64V	PTK2_uc003yvs.2_Silent_p.V64V|PTK2_uc003yvt.2_Silent_p.V86V|PTK2_uc003yvv.2_Nonsense_Mutation_p.S7*|PTK2_uc011ljr.1_Silent_p.V64V	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	64	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TACTTACCCTGACATCAGTAG	0.343													12	69					0	0	0	0	C	141900645	C	C	141900645	2	2	72	1	0	0	0	0	0	0	0	1	12825	1277	45	2		2	PTK2	8	141900645	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	24032207	141900645	4463377	96	14798											
ACER2	340485	broad.mit.edu	37	chr9	19435048	19435048	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctctgatgaccctgggagttCcttgcactgcactgctcatc	6	12	9	14	0	2	2	1	2	1	0	4	3	3	3	2	1	3	4	2	1	0	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:19435048C>T	uc003zny.1	+	4	627	c.469C>T	c.(469-471)CCT>TCT	p.P157S	ACER2_uc003znx.1_RNA|ACER2_uc003znz.1_Missense_Mutation_p.P108S	NM_001010887	NP_001010887	Q5QJU3	ACER2_HUMAN	alkaline ceramidase 2	157	Helical; (Potential).				ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2						CCTGGGAGTTCCTTGCACTGC	0.552													16	48					0	0	0	0	T	19435048	T	T	19435048	3	4	72	1	0	0	0	0	1	0	0	0	139	855	30	2	483	2	ACER2	9	19435048	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08		19435048	121778383	97	14799											
CDKN2A	1029	broad.mit.edu	37	chr9	21971096	21971096	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcgtgtccaggaagccctCccgggcagcgtcgtgcacgg	6	5	15	15	5	0	0	0	0	0	0	3	1	2	1	3	3	4	2	3	3	1	0	rs121913384		TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:21971096C>A	uc003zpk.2	-	2	474	c.262G>T	c.(262-264)GAG>TAG	p.E88*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.G143V	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	88	ANK 3.		E -> D (in a biliary tract tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E88*(13)|p.E88E(6)|p.E88K(3)|p.H83fs*2(2)|p.E88D(2)|p.E88A(1)|p.E88G(1)|p.D84_F90del(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.E88V(1)|p.E87K(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		AGGAAGCCCTCCCGGGCAGCG	0.756	E88*(CAL33_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			11	9					1.5842e-08	1.68199e-08	1	0	A	21971096	A	A	21971096	4	1	72	1	0	0	0	0	0	1	0	0	3176	864	30	2	216	2	CDKN2A	9	21971096	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	2536048	21971096	119242335	98	14800											
RUSC2	9853	broad.mit.edu	37	chr9	35558285	35558285	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccgcgccgtgctggaggatgGgctcaaggcctttgtactgg	5	9	16	11	3	1	0	1	0	0	0	1	2	1	2	3	5	2	3	3	5	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:35558285G>A	uc003zww.2	+	7	3407	c.3152G>A	c.(3151-3153)GGG>GAG	p.G1051E	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.G1051E	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1051	RUN.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			CTGGAGGATGGGCTCAAGGCC	0.582													8	58					0	0	0	0	A	35558285	A	A	35558285	3	1	72	1	0	0	0	0	1	0	0	0	13816	1232	43	4	3174	4	RUSC2	9	35558285	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	13587189	35558285	105655146	99	14801											
FBXO10	26267	broad.mit.edu	37	chr9	37512661	37512661	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggctgccgagggacgtctGagagaattttcaaggtgggg	8	9	18	6	2	2	2	1	1	1	1	2	5	2	3	1	5	1	1	1	5	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:37512661G>C	uc004aab.2	-	11	2803	c.2754C>G	c.(2752-2754)CTC>CTG	p.L918L	FBXO10_uc004aac.2_Silent_p.L934L|FBXO10_uc004aad.2_Silent_p.L468L	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	918						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		AGGGACGTCTGAGAGAATTTT	0.582													18	54					0	0	0	0	C	37512661	C	C	37512661	2	2	72	1	0	0	0	0	0	0	0	1	5758	1277	45	2		2	FBXO10	9	37512661	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	1954376	37512661	103700770	100	14802											
SHB	6461	broad.mit.edu	37	chr9	38016078	38016078	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctttcctgctttgctcttGagatcattcttggcatcaaa	7	16	6	12	0	4	1	2	1	2	1	5	2	5	1	2	1	2	3	2	1	1	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:38016078G>C	uc004aax.2	-	2	1336	c.768C>G	c.(766-768)CTC>CTG	p.L256L		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	256	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		CTTTGCTCTTGAGATCATTCT	0.522													6	83					0	0	0	0	C	38016078	C	C	38016078	2	2	72	1	0	0	0	0	0	0	0	1	14333	1277	45	2		2	SHB	9	38016078	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	503417	38016078	103197353	101	14803											
FAM108B1	51104	broad.mit.edu	37	chr9	74481894	74481894	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccatgaattattaatactgGagaggttatcttagagattt	13	15	8	5	0	1	3	0	1	1	2	1	5	1	3	1	2	1	1	1	2	6	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:74481894G>A	uc004aim.1	-	4	1278	c.676C>T	c.(676-678)CCA>TCA	p.P226S	FAM108B1_uc004ail.2_Missense_Mutation_p.P226S	NM_001025780	NP_001020951	Q5VST6	F108B_HUMAN	family with sequence similarity 108, member B1	226						extracellular region	hydrolase activity				0						ATTAATACTGGAGAGGTTATC	0.393													8	39					0	0	0	0	A	74481894	A	A	74481894	3	1	72	1	0	0	0	0	1	0	0	0	5420	1174	41	2	225	2	FAM108B1	9	74481894	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	36465816	74481894	66731537	102	14804											
NXNL2	158046	broad.mit.edu	37	chr9	91150602	91150602	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatgctggacttcatgcgcGagctgcatggcgcctggctg	6	9	15	11	3	1	1	1	0	0	1	1	3	1	2	1	3	4	4	1	3	0	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:91150602G>A	uc011ltj.1	+	1	587	c.253G>A	c.(253-255)GAG>AAG	p.E85K	NXNL2_uc004aqa.2_Missense_Mutation_p.E85K	NM_001161625	NP_001155097	Q5VZ03	NXNL2_HUMAN	nucleoredoxin-like 2 isoform 1	85	Thioredoxin.										0						CTTCATGCGCGAGCTGCATGG	0.617													3	37					0	0	0	0	A	91150602	A	A	91150602	3	1	72	1	0	0	0	0	1	0	0	0	10843	1059	37	1	255	1	NXNL2	9	91150602	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	16668708	91150602	50062829	103	14805											
XPA	7507	broad.mit.edu	37	chr9	100459507	100459507	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctcgatactcgcccgcaccGaggcaggcagctccgcgggt	6	5	14	16	6	0	0	0	0	0	0	3	2	1	0	3	3	2	5	3	3	1	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:100459507G>A	uc004axr.3	-	1	185	c.68C>T	c.(67-69)TCG>TTG	p.S23L	XPA_uc004axs.3_RNA	NM_000380	NP_000371	P23025	XPA_HUMAN	xeroderma pigmentosum, complementation group A	23	Interaction with CEP164 and required for UV resistance.				nucleotide-excision repair, DNA damage removal	nucleoplasm	damaged DNA binding|metal ion binding|nucleotide binding|protein domain specific binding|protein homodimerization activity			breast(1)	1		Acute lymphoblastic leukemia(62;0.158)				CGCCCGCACCGAGGCAGGCAG	0.731			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				6	26					0	0	0	0	A	100459507	A	A	100459507	3	1	72	1	0	0	0	0	1	0	0	0	17508	1059	37	1	777	1	XPA	9	100459507	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	9308905	100459507	40753924	104	14806											
ZNF189	7743	broad.mit.edu	37	chr9	104170889	104170889	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaccttattgagcatcaaaGaactcacactggtgagaaac	16	8	7	10	0	2	3	2	2	0	2	2	4	2	3	1	1	3	1	1	1	4	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:104170889G>A	uc004bbh.1	+	3	1115	c.839G>A	c.(838-840)AGA>AAA	p.R280K	ZNF189_uc004bbg.1_Missense_Mutation_p.R238K|ZNF189_uc004bbi.1_Missense_Mutation_p.R266K|ZNF189_uc011lvk.1_Missense_Mutation_p.R265K	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	280	C2H2-type 5.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				GAGCATCAAAGAACTCACACT	0.393													27	226					0	0	0	0	A	104170889	A	A	104170889	3	1	72	1	0	0	0	0	1	0	0	0	17821	942	33	2	849	2	ZNF189	9	104170889	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	3711382	104170889	37042542	105	14807											
GOLGA2	2801	broad.mit.edu	37	chr9	131019928	131019928	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctgatgtactcctccttCtcccggtgccgctccttcag	3	13	8	17	2	2	1	1	1	1	0	6	1	5	1	5	1	3	3	5	1	1	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:131019928C>T	uc011maw.1	-	24	2602	c.2589G>A	c.(2587-2589)GAG>GAA	p.E863E	GOLGA2_uc010mxw.2_Silent_p.E186E|GOLGA2_uc004buh.2_Intron	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	863	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						ACTCCTCCTTCTCCCGGTGCC	0.622													26	102					0	0	0	0	T	131019928	T	T	131019928	2	4	72	1	0	0	0	0	0	0	0	1	6589	912	32	2		2	GOLGA2	9	131019928	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	26849039	131019928	10193503	106	14808											
SETX	23064	broad.mit.edu	37	chr9	135163631	135163631	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgcaaagatacctgtatttCccgtccacctcggcatagag	11	10	8	12	2	0	2	0	0	0	2	3	2	2	2	4	1	2	3	4	1	4	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr9:135163631C>T	uc004cbk.2	-	17	6499	c.6316G>A	c.(6316-6318)GAA>AAA	p.E2106K	SETX_uc004cbj.2_Missense_Mutation_p.E1725K|SETX_uc010mzt.2_Missense_Mutation_p.E1725K	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2106	Potential.				cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ACCTGTATTTCCCGTCCACCT	0.338													10	22					0	0	0	0	T	135163631	T	T	135163631	3	4	72	1	0	0	0	0	1	0	0	0	14206	864	30	2	1757	2	SETX	9	135163631	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	4143703	135163631	6049800	107	14809											
ZNF37A	7587	broad.mit.edu	37	chr10	38407109	38407109	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaaaagtcaacccttactCaacatcaaagaacgcacaca	18	6	5	12	1	3	2	3	1	0	1	3	2	3	2	1	0	4	1	1	0	7	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr10:38407109C>T	uc001izk.2	+	8	1849	c.1030C>T	c.(1030-1032)CAA>TAA	p.Q344*	ZNF37A_uc001izl.2_Nonsense_Mutation_p.Q344*|ZNF37A_uc001izm.2_Nonsense_Mutation_p.Q344*	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	344	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						AACCCTTACTCAACATCAAAG	0.398													11	74					0	0	0	0	T	38407109	T	T	38407109	4	4	72	1	0	0	0	0	0	1	0	0	17939	827	29	2	1044	2	ZNF37A	10	38407109	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08		38407109	97127638	108	14810											
RBP3	5949	broad.mit.edu	37	chr10	48388281	48388281	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgggctccccaatgaccGtggcccgctgcaggtcctgc	4	7	13	17	3	0	1	0	1	0	0	2	1	2	1	6	3	2	3	6	3	1	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr10:48388281G>A	uc001jez.2	-	1	2711	c.2597C>T	c.(2596-2598)ACG>ATG	p.T866M		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	866	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CCCAATGACCGTGGCCCGCTG	0.637													6	34					0	0	0	0	A	48388281	A	A	48388281	3	1	72	1	0	0	0	0	1	0	0	0	13222	1145	40	1	1162	1	RBP3	10	48388281	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	9981172	48388281	87146466	109	14811											
CCDC109A	90550	broad.mit.edu	37	chr10	74628472	74628472	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtttcagacctcttaagtCatgaaaatgcagcaacgctg	12	12	8	9	1	3	2	2	1	1	1	3	2	3	2	1	0	3	4	1	0	4	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr10:74628472C>T	uc001jtc.2	+	5	529	c.508C>T	c.(508-510)CAT>TAT	p.H170Y	CCDC109A_uc009xqp.1_RNA|CCDC109A_uc009xqq.1_RNA|CCDC109A_uc010qjy.1_RNA|CCDC109A_uc009xqr.2_Intron|CCDC109A_uc001jtd.2_Missense_Mutation_p.H121Y	NM_138357	NP_612366	Q8NE86	MCU_HUMAN	coiled-coil domain containing 109A	170	Mitochondrial matrix (Potential).				elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding				0	Prostate(51;0.0198)					CCTCTTAAGTCATGAAAATGC	0.383													14	74					0	0	0	0	T	74628472	T	T	74628472	3	4	72	1	0	0	0	0	1	0	0	0	2756	826	29	2	526	2	CCDC109A	10	74628472	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	26240191	74628472	60906275	110	14812											
KCNMA1	3778	broad.mit.edu	37	chr10	78846273	78846273	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgcaagatcatgtggattGaggacggaaccctgataaaa	14	9	11	7	1	1	3	1	2	0	1	1	6	1	6	1	3	2	1	1	3	4	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr10:78846273G>A	uc001jxn.2	-	11	1590	c.1413C>T	c.(1411-1413)CTC>CTT	p.L471L	KCNMA1_uc001jxj.2_Silent_p.L471L|KCNMA1_uc001jxk.1_Silent_p.L86L|KCNMA1_uc009xrt.1_Silent_p.L291L|KCNMA1_uc001jxl.1_Silent_p.L125L|KCNMA1_uc001jxo.2_Silent_p.L471L|KCNMA1_uc001jxm.2_Silent_p.L471L|KCNMA1_uc001jxq.2_Silent_p.L471L	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	471	RCK N-terminal.|Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CATGTGGATTGAGGACGGAAC	0.483													10	49					0	0	0	0	A	78846273	A	A	78846273	2	1	72	1	0	0	0	0	0	0	0	1	8112	1277	45	2		2	KCNMA1	10	78846273	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	4217801	78846273	56688474	111	14813											
PSD	5662	broad.mit.edu	37	chr10	104172143	104172143	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctagtggctttacttcttGcccaggtgccgggccacatc	5	11	11	14	1	1	0	0	0	1	0	2	0	1	0	4	3	3	1	4	3	2	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr10:104172143G>A	uc001kvg.1	-	6	2270	c.1743C>T	c.(1741-1743)GGC>GGT	p.G581G	PSD_uc001kvh.1_Silent_p.G202G|PSD_uc009xxd.1_Silent_p.G581G	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	581	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TTTACTTCTTGCCCAGGTGCC	0.602													4	43					0	0	0	0	A	104172143	A	A	104172143	2	1	72	1	0	0	0	0	0	0	0	1	12708	1306	46	4		4	PSD	10	104172143	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	25325870	104172143	31362604	112	14814											
CUEDC2	79004	broad.mit.edu	37	chr10	104184420	104184420	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctacctggggatgtgggcGaagccaggcacataggcctc	9	6	14	12	1	0	0	0	0	0	0	1	2	0	1	4	5	2	1	4	5	3	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr10:104184420G>A	uc001kvn.2	-	3	355	c.204C>T	c.(202-204)TTC>TTT	p.F68F	CUEDC2_uc001kvm.2_5'Flank	NM_024040	NP_076945	Q9H467	CUED2_HUMAN	CUE domain containing 2	68						cytoplasm|nucleus	protein binding				0		Colorectal(252;0.122)		Epithelial(162;9.17e-09)|all cancers(201;2.16e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GGATGTGGGCGAAGCCAGGCA	0.597													13	82					0	0	0	0	A	104184420	A	A	104184420	2	1	72	1	0	0	0	0	0	0	0	1	4070	1049	37	1		1	CUEDC2	10	104184420	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	12277	104184420	31350327	113	14815											
SEC23IP	11196	broad.mit.edu	37	chr10	121685713	121685713	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttctgtgtgtgtgaattatGaatcttttgaagttggcgcc	7	17	11	6	1	2	3	0	3	2	0	2	3	2	3	1	1	0	1	1	1	4	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr10:121685713G>A	uc001leu.1	+	13	2359	c.2287G>A	c.(2287-2289)GAA>AAA	p.E763K	SEC23IP_uc010qtc.1_Missense_Mutation_p.E552K|SEC23IP_uc009xzk.1_RNA	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	763					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TGTGAATTATGAATCTTTTGA	0.433													19	92					0	0	0	0	A	121685713	A	A	121685713	3	1	72	1	0	0	0	0	1	0	0	0	14058	1291	45	2	2337	2	SEC23IP	10	121685713	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	17501293	121685713	13849034	114	14816											
SEC23IP	11196	broad.mit.edu	37	chr10	121689932	121689932	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatcacaaaggcagaaaaaGacttcatttaggtaaaaagc	20	7	7	7	0	2	2	2	0	0	2	2	2	2	2	0	2	1	2	0	2	7	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr10:121689932G>C	uc001leu.1	+	15	2633	c.2561G>C	c.(2560-2562)AGA>ACA	p.R854T	SEC23IP_uc010qtc.1_Missense_Mutation_p.R643T|SEC23IP_uc009xzk.1_Intron	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	854	DDHD.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		GGCAGAAAAAGACTTCATTTA	0.313													13	54					0	0	0	0	C	121689932	C	C	121689932	3	2	72	1	0	0	0	0	1	0	0	0	14058	942	33	2	2619	2	SEC23IP	10	121689932	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	4219	121689932	13844815	115	14817											
CUZD1	50624	broad.mit.edu	37	chr10	124608956	124608956	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcaggttcctttgcagctCttgagaaaagacacacacaa	13	10	7	11	0	2	2	1	1	1	2	3	3	3	2	1	1	2	3	1	1	3	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr10:124608956C>G	uc001lgs.2	-	2	372	c.-579_splice	c.e2-1		CUZD1_uc010qtz.1_Intron|FAM24B_uc001lgt.2_Intron	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor						cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		CTTTGCAGCTCTTGAGAAAAG	0.483													13	59					0	0	0	0	G	124608956	G	G	124608956	5	3	72	1	0	0	0	0	0	0	1	0	4083	927	32	2		2	CUZD1	10	124608956	Splice_Site	SNP	C	TCGA-CN-6013-01A-11D-1683-08	2919024	124608956	10925791	116	14818											
PHRF1	57661	broad.mit.edu	37	chr11	606519	606519	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cctgctgggcagcatcctgtCgggccagagcctcctgatgc	5	8	13	15	1	0	2	0	1	0	1	3	2	2	2	5	2	4	3	5	2	0	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr11:606519C>G	uc001lqe.2	+	13	1663	c.1532C>G	c.(1531-1533)TCG>TGG	p.S511W	PHRF1_uc010qwc.1_Missense_Mutation_p.S510W|PHRF1_uc010qwd.1_Missense_Mutation_p.S509W|PHRF1_uc010qwe.1_Missense_Mutation_p.S507W|PHRF1_uc009ybz.1_Missense_Mutation_p.S301W|PHRF1_uc009yca.1_5'Flank	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	511							RNA polymerase binding|zinc ion binding				0						AGCATCCTGTCGGGCCAGAGC	0.687													4	19					0	0	0	0	G	606519	G	G	606519	3	3	72	1	0	0	0	0	1	0	0	0	11916	893	31	3	1575	3	PHRF1	11	606519	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08		606519	134399997	117	14819											
IRF7	3665	broad.mit.edu	37	chr11	613228	613228	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggaagaagactctgaagtcGaagatgggggtgtcacagtt	12	9	15	5	1	2	4	1	1	1	3	3	6	2	5	0	3	0	1	0	3	4	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr11:613228G>A	uc001lqh.2	-	9	1585	c.1215C>T	c.(1213-1215)TTC>TTT	p.F405F	IRF7_uc009ycb.2_Silent_p.F299F|IRF7_uc010qwf.1_Silent_p.F404F|IRF7_uc001lqf.2_Silent_p.F112F|IRF7_uc010qwg.1_Silent_p.F112F|IRF7_uc001lqg.2_Silent_p.F418F|IRF7_uc001lqi.2_Silent_p.F376F|IRF7_uc010qwh.1_Silent_p.F112F	NM_001572	NP_001563	Q92985	IRF7_HUMAN	interferon regulatory factor 7 isoform a	405					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTCTGAAGTCGAAGATGGGGG	0.652													5	15					0	0	0	0	A	613228	A	A	613228	2	1	72	1	0	0	0	0	0	0	0	1	7874	1049	37	1		1	IRF7	11	613228	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	6709	613228	134393288	118	14820											
CTR9	9646	broad.mit.edu	37	chr11	10794110	10794110	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcccagtaccatgtggccCgggcacgcaaacaagatgaa	13	4	12	12	2	0	2	0	1	0	1	0	2	0	2	3	3	2	3	3	3	4	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr11:10794110C>T	uc001mja.2	+	20	2637	c.2488C>T	c.(2488-2490)CGG>TGG	p.R830W		NM_014633	NP_055448	Q6PD62	CTR9_HUMAN	SH2 domain binding protein 1	830					histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				ovary(2)	2				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CCATGTGGCCCGGGCACGCAA	0.453													14	42					0	0	0	0	T	10794110	T	T	10794110	3	4	72	1	0	0	0	0	1	0	0	0	4041	643	23	1	2566	1	CTR9	11	10794110	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	10180882	10794110	124212406	119	14821											
INSC	387755	broad.mit.edu	37	chr11	15222370	15222370	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acatttctttctcttggcagGagggtggggtcgtagcactc	6	13	13	9	1	2	0	0	0	2	0	5	1	2	1	0	5	1	3	0	5	1	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr11:15222370G>A	uc001mly.2	+	7	881	c.835G>A	c.(835-837)GAG>AAG	p.E279K	INSC_uc001mlz.2_Missense_Mutation_p.E232K|INSC_uc001mma.2_Missense_Mutation_p.E232K|INSC_uc010rcs.1_Missense_Mutation_p.E267K|INSC_uc001mmb.2_Missense_Mutation_p.E232K|INSC_uc001mmc.2_Intron	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	279					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CTCTTGGCAGGAGGGTGGGGT	0.547													4	30					0	0	0	0	A	15222370	A	A	15222370	3	1	72	1	0	0	0	0	1	0	0	0	7803	1188	41	2	861	2	INSC	11	15222370	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	4428260	15222370	119784146	120	14822											
DGKZ	8525	broad.mit.edu	37	chr11	46393102	46393102	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgctcgctgggggtccaCgcagccgtggtcatcccgcc	3	7	14	17	5	1	0	1	0	0	0	4	0	3	0	5	3	2	3	5	3	0	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr11:46393102C>T	uc001ncn.1	+	9	1397	c.1272C>T	c.(1270-1272)CAC>CAT	p.H424H	DGKZ_uc001nch.1_Silent_p.H252H|DGKZ_uc010rgq.1_Silent_p.H179H|DGKZ_uc001ncj.1_Silent_p.H202H|DGKZ_uc010rgr.1_Silent_p.H201H|DGKZ_uc001nck.1_Silent_p.H14H|DGKZ_uc001ncl.2_Silent_p.H236H|DGKZ_uc001ncm.2_Silent_p.H235H|DGKZ_uc009yky.1_Silent_p.H236H|DGKZ_uc010rgs.1_Silent_p.H213H	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	424					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TGGGGGTCCACGCAGCCGTGG	0.687													7	20					0	0	0	0	T	46393102	T	T	46393102	2	4	72	1	0	0	0	0	0	0	0	1	4496	535	19	1		1	DGKZ	11	46393102	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	31170732	46393102	88613414	121	14823											
PLCB3	5331	broad.mit.edu	37	chr11	64029989	64029989	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtccttcgaccccttcactGaggtcatcgtggatggcatc	7	11	10	13	2	2	1	2	1	0	0	6	3	3	2	3	3	0	1	3	3	0	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr11:64029989G>A	uc001nzb.2	+	18	2149	c.2149G>A	c.(2149-2151)GAG>AAG	p.E717K	PLCB3_uc009ypg.1_Missense_Mutation_p.E717K|PLCB3_uc009yph.1_Missense_Mutation_p.E650K|PLCB3_uc009ypi.2_Missense_Mutation_p.E717K	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	717	C2.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CCCCTTCACTGAGGTCATCGT	0.647													18	42					0	0	0	0	A	64029989	A	A	64029989	3	1	72	1	0	0	0	0	1	0	0	0	12084	1291	45	2	2219	2	PLCB3	11	64029989	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	17636887	64029989	70976527	122	14824											
MLL	4297	broad.mit.edu	37	chr11	118362545	118362545	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggcaccctgcagagtggCgactggcccttgaaaaagag	11	5	14	11	2	0	3	0	1	0	2	0	4	0	3	2	3	2	2	2	3	2	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr11:118362545C>T	uc001pta.2	+	15	4920	c.4897C>T	c.(4897-4899)CGA>TGA	p.R1633*	MLL_uc001ptb.2_Nonsense_Mutation_p.R1636*|MLL_uc001pte.1_RNA	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1633					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TGCAGAGTGGCGACTGGCCCT	0.468			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								14	32					0	0	0	0	T	118362545	T	T	118362545	4	4	72	1	0	0	0	0	0	1	0	0	9673	760	27	1	4955	1	MLL	11	118362545	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	54332556	118362545	16643971	123	14825											
SPSB2	84727	broad.mit.edu	37	chr12	6980481	6980481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgcagaagggagtgtggctCcgctgggagagagaaggagg	10	5	21	5	1	0	3	0	0	0	3	1	7	1	5	1	5	1	3	1	5	2	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:6980481C>T	uc001qrl.2	-	3	823	c.667G>A	c.(667-669)GAG>AAG	p.E223K	SPSB2_uc001qrm.2_Missense_Mutation_p.E223K|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	223	SOCS box.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1						GAGTGTGGCTCCGCTGGGAGA	0.617													5	36					0	0	0	0	T	6980481	T	T	6980481	3	4	72	1	0	0	0	0	1	0	0	0	15179	864	30	2	128	2	SPSB2	12	6980481	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08		6980481	126871414	124	14826											
PIK3C2G	5288	broad.mit.edu	37	chr12	18719918	18719918	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcacctaccttttacaaattCagatcacagaagattcagag	15	10	6	10	0	3	4	3	0	0	4	3	4	3	4	2	0	2	1	2	0	4	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:18719918C>T	uc001rdt.2	+	28	3931	c.3815C>T	c.(3814-3816)TCA>TTA	p.S1272L	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.S1313L|PIK3C2G_uc010sic.1_Missense_Mutation_p.S1091L	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1272	PX.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				TTTACAAATTCAGATCACAGA	0.289													11	76					0	0	0	0	T	18719918	T	T	18719918	3	4	72	1	0	0	0	0	1	0	0	0	11966	838	29	2	3921	2	PIK3C2G	12	18719918	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	11739437	18719918	115131977	125	14827											
SLCO1A2	6579	broad.mit.edu	37	chr12	21422497	21422497	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaattacaatttagttttCaattcatcatctttcaaaac	15	16	2	8	0	5	0	4	0	1	0	5	1	5	0	0	0	2	1	0	0	7	7			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:21422497C>T	uc001rer.2	-	14	2249	c.1998G>A	c.(1996-1998)TTG>TTA	p.L666L	SLCO1A2_uc001res.2_Silent_p.L666L|SLCO1A2_uc010siq.1_Silent_p.L534L|SLCO1A2_uc010sio.1_Silent_p.L534L|SLCO1A2_uc010sip.1_Silent_p.L534L	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	666	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						ATTTAGTTTTCAATTCATCAT	0.299													18	87					0	0	0	0	T	21422497	T	T	21422497	2	4	72	1	0	0	0	0	0	0	0	1	14786	825	29	2		2	SLCO1A2	12	21422497	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	2702579	21422497	112429398	126	14828											
KIAA0528	9847	broad.mit.edu	37	chr12	22680820	22680820	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatcttgtaagtcttcatCatccacctacaagtatacct	11	15	3	12	0	5	0	3	0	2	0	6	0	6	0	3	0	2	2	3	0	5	7			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:22680820C>T	uc001rfq.2	-	4	412	c.184G>A	c.(184-186)GAT>AAT	p.D62N	KIAA0528_uc010sir.1_5'UTR|KIAA0528_uc010sis.1_Missense_Mutation_p.D62N|KIAA0528_uc010sit.1_Missense_Mutation_p.D62N|KIAA0528_uc010siu.1_Missense_Mutation_p.D62N|KIAA0528_uc001rfr.2_Missense_Mutation_p.D62N|KIAA0528_uc009ziy.1_Missense_Mutation_p.D62N	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	62	C2.						protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						AAGTCTTCATCATCCACCTAC	0.313													6	57					0	0	0	0	T	22680820	T	T	22680820	3	4	72	1	0	0	0	0	1	0	0	0	8221	826	29	2	2906	2	KIAA0528	12	22680820	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	1258323	22680820	111171075	127	14829											
SOX5	6660	broad.mit.edu	37	chr12	23818434	23818434	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaatccttgctgggcagctGcagccagtgtccgttgatca	7	10	13	11	1	1	1	1	1	0	0	3	2	3	2	3	2	4	5	3	2	1	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:23818434G>T	uc001rfw.2	-	7	977	c.875C>A	c.(874-876)GCA>GAA	p.A292E	SOX5_uc001rfx.2_Missense_Mutation_p.A279E|SOX5_uc001rfy.2_Missense_Mutation_p.A279E|SOX5_uc010siv.1_Missense_Mutation_p.A279E|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.A244E	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	292					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						CTGGGCAGCTGCAGCCAGTGT	0.507													61	95					9.53978e-28	1.05182e-27	1	0	T	23818434	T	T	23818434	3	4	72	1	0	0	0	0	1	0	0	0	15018	1319	46	4	1462	4	SOX5	12	23818434	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	1137614	23818434	110033461	128	14830											
ITPR2	3709	broad.mit.edu	37	chr12	26592150	26592150	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttccttgttcatccctttCagttgtattgaacacacggc	8	15	6	12	1	2	1	2	1	0	0	4	1	4	1	2	1	1	3	2	1	2	7			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:26592150C>T	uc001rhg.2	-	47	6970	c.6553G>A	c.(6553-6555)GAA>AAA	p.E2185K	ITPR2_uc009zjg.1_Missense_Mutation_p.E336K	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2185	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCATCCCTTTCAGTTGTATTG	0.403													13	88					0	0	0	0	T	26592150	T	T	26592150	3	4	72	1	0	0	0	0	1	0	0	0	7960	835	29	2	1596	2	ITPR2	12	26592150	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	2773716	26592150	107259745	129	14831											
BICD1	636	broad.mit.edu	37	chr12	32369208	32369208	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagtccttctccatccacCggaaggttgctgaagatgga	9	9	12	11	1	1	2	0	1	1	1	4	4	3	4	4	4	1	3	4	4	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:32369208C>T	uc001rku.2	+	2	322	c.241C>T	c.(241-243)CGG>TGG	p.R81W	BICD1_uc001rkv.2_Missense_Mutation_p.R81W|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	81	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CTCCATCCACCGGAAGGTTGC	0.468													11	28					0	0	0	0	T	32369208	T	T	32369208	3	4	72	1	0	0	0	0	1	0	0	0	1431	643	23	1	247	1	BICD1	12	32369208	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	5777058	32369208	101482687	130	14832											
SYT10	341359	broad.mit.edu	37	chr12	33535294	33535294	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atacacatacctatcgtaatCcatgaccgcaatggagaggc	14	8	8	11	2	0	2	0	1	0	1	2	3	1	2	3	2	2	2	3	2	5	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:33535294C>T	uc001rll.1	-	5	1657	c.1360G>A	c.(1360-1362)GAT>AAT	p.D454N	SYT10_uc009zju.1_Missense_Mutation_p.D264N	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	454	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CTATCGTAATCCATGACCGCA	0.458													6	47					0	0	0	0	T	33535294	T	T	33535294	3	4	72	1	0	0	0	0	1	0	0	0	15532	855	30	2	223	2	SYT10	12	33535294	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	1166086	33535294	100316601	131	14833											
CNTN1	1272	broad.mit.edu	37	chr12	41352971	41352971	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagctgaaacatgctggaaGatacacatgcactgcccaga	14	6	10	11	0	0	3	0	1	0	2	0	4	0	4	1	1	6	4	1	1	3	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:41352971G>A	uc001rmm.1	+	15	1852	c.1739G>A	c.(1738-1740)AGA>AAA	p.R580K	CNTN1_uc009zjy.1_Missense_Mutation_p.R580K|CNTN1_uc001rmn.1_Missense_Mutation_p.R569K|CNTN1_uc001rmo.2_Missense_Mutation_p.R580K	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	580	Ig-like C2-type 6.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CATGCTGGAAGATACACATGC	0.388													13	53					0	0	0	0	A	41352971	A	A	41352971	3	1	72	1	0	0	0	0	1	0	0	0	3655	942	33	2	1793	2	CNTN1	12	41352971	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	7817677	41352971	92498924	132	14834											
DIP2B	57609	broad.mit.edu	37	chr12	51108292	51108292	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagacgaaacaactctttCtggagggatcactgcatcct	11	10	8	12	1	4	1	2	0	2	1	5	4	5	3	1	2	3	1	1	2	2	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:51108292C>G	uc001rwv.2	+	23	2920	c.2764C>G	c.(2764-2766)CTG>GTG	p.L922V	DIP2B_uc009zlt.2_Missense_Mutation_p.L352V	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	922						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						ACAACTCTTTCTGGAGGGATC	0.473													15	64					0	0	0	0	G	51108292	G	G	51108292	3	3	72	1	0	0	0	0	1	0	0	0	4550	912	32	2	2854	2	DIP2B	12	51108292	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	9755321	51108292	82743603	133	14835											
KRT4	3851	broad.mit.edu	37	chr12	53201525	53201525	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtactcacgcagcattcGtgccagctcctccttggcct	5	11	9	16	2	1	0	1	0	0	0	4	0	3	0	4	2	4	4	4	2	1	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:53201525G>A	uc001saz.2	-	7	1742	c.1471C>T	c.(1471-1473)CGA>TGA	p.R491*		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	417						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						CGCAGCATTCGTGCCAGCTCC	0.602													19	58					0	0	0	0	A	53201525	A	A	53201525	4	1	72	1	0	0	0	0	0	1	0	0	8516	1153	40	1	325	1	KRT4	12	53201525	Nonsense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	2093233	53201525	80650370	134	14836											
CDK17	5128	broad.mit.edu	37	chr12	96728558	96728558	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaattcagacaatgattcAtcaatagtctgacttcctcg	12	12	6	11	1	4	3	3	2	1	1	6	3	5	3	2	0	0	0	2	0	4	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:96728558A>G	uc001tep.1	-	2	546	c.57T>C	c.(55-57)GAT>GAC	p.D19D	CDK17_uc009ztk.2_Silent_p.D19D|CDK17_uc010svb.1_Intron	NM_002595	NP_002586	Q00537	CDK17_HUMAN	PCTAIRE protein kinase 2	19							ATP binding|cyclin-dependent protein kinase activity			ovary(3)|lung(2)|kidney(1)|central_nervous_system(1)	7						ACAATGATTCATCAATAGTCT	0.368													7	30					0	0	0	0	G	96728558	G	G	96728558	2	3	72	1	0	0	0	0	0	0	0	1	3148	214	8	5		5	CDK17	12	96728558	Silent	SNP	A	TCGA-CN-6013-01A-11D-1683-08	43527033	96728558	37123337	135	14837											
RASAL1	8437	broad.mit.edu	37	chr12	113544929	113544929	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccatccacatccaccagccGgtccaggaagtctctcacac	10	6	6	19	1	2	0	1	0	1	0	6	1	5	1	6	2	1	0	6	2	1	0	rs61759863		TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:113544929G>A	uc001tum.1	-	16	1923	c.1630C>T	c.(1630-1632)CGG>TGG	p.R544W	RASAL1_uc010syp.1_Missense_Mutation_p.R544W|RASAL1_uc001tul.2_Missense_Mutation_p.R544W|RASAL1_uc001tun.1_Missense_Mutation_p.R545W|RASAL1_uc010syq.1_Missense_Mutation_p.R544W|RASAL1_uc001tuo.3_Missense_Mutation_p.R544W|RASAL1_uc010syr.1_3'UTR	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	544					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						TCCACCAGCCGGTCCAGGAAG	0.607													16	35					0	0	0	0	A	113544929	A	A	113544929	3	1	72	1	0	0	0	0	1	0	0	0	13128	1115	39	1	812	1	RASAL1	12	113544929	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	16816371	113544929	20306966	136	14838											
GPR133	283383	broad.mit.edu	37	chr12	131475580	131475580	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagcatgctttattgtcttCaacgctgccaagcctcttca	10	13	6	12	1	4	0	2	0	2	0	4	0	4	0	2	0	5	3	2	0	4	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:131475580C>T	uc001uit.3	+	7	1326	c.767C>T	c.(766-768)TCA>TTA	p.S256L	GPR133_uc010tbm.1_Missense_Mutation_p.S288L	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	256	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TTATTGTCTTCAACGCTGCCA	0.468													6	17					0	0	0	0	T	131475580	T	T	131475580	3	4	72	1	0	0	0	0	1	0	0	0	6681	838	29	2	793	2	GPR133	12	131475580	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	17930651	131475580	2376315	137	14839											
ULK1	8408	broad.mit.edu	37	chr12	132404541	132404541	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtggtgcgcaggctgaatGagctgtacaaggccagcgtg	9	7	16	9	2	0	2	0	2	0	0	0	2	0	2	1	3	4	4	1	3	3	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr12:132404541G>A	uc001uje.2	+	26	3089	c.2821G>A	c.(2821-2823)GAG>AAG	p.E941K		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	941					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CAGGCTGAATGAGCTGTACAA	0.642													11	44					0	0	0	0	A	132404541	A	A	132404541	3	1	72	1	0	0	0	0	1	0	0	0	17043	1291	45	2	2923	2	ULK1	12	132404541	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	928961	132404541	1447354	138	14840											
NHLRC3	387921	broad.mit.edu	37	chr13	39618234	39618234	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaccgtttatagatttcatGatcctttggctgcatggaga	9	16	9	7	1	1	3	1	1	0	2	2	4	2	3	2	2	2	3	2	2	3	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr13:39618234G>A	uc001uxc.2	+	5	916	c.594G>A	c.(592-594)ATG>ATA	p.M198I	NHLRC3_uc001uxb.1_Missense_Mutation_p.M198I|NHLRC3_uc001uxd.2_Missense_Mutation_p.M131I|NHLRC3_uc001uxe.2_Missense_Mutation_p.M1I	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	198						extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		TAGATTTCATGATCCTTTGGC	0.373													44	198					0	0	0	0	A	39618234	A	A	39618234	3	1	72	1	0	0	0	0	1	0	0	0	10461	1290	45	2	612	2	NHLRC3	13	39618234	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08		39618234	75551644	139	14841											
KLHL1	57626	broad.mit.edu	37	chr13	70456505	70456505	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatacttgacccacatcatCaatgcatggaagatggtttc	12	12	7	10	0	3	2	3	1	0	1	4	3	3	3	1	2	2	2	1	2	3	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr13:70456505C>A	uc001vip.2	-	5	1931	c.1137G>T	c.(1135-1137)TTG>TTT	p.L379F	KLHL1_uc010thm.1_Missense_Mutation_p.L318F	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	379					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CCCACATCATCAATGCATGGA	0.438													26	56					1.03073e-24	1.13161e-24	1	0	A	70456505	A	A	70456505	3	1	72	1	0	0	0	0	1	0	0	0	8404	825	29	2	1137	2	KLHL1	13	70456505	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	30838271	70456505	44713373	140	14842											
RBM26	64062	broad.mit.edu	37	chr13	79894788	79894788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaacgagattcattgtcctCttcttcttcatcatcatctt	9	17	4	11	1	8	2	4	0	4	2	9	3	9	2	1	0	1	0	1	0	1	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr13:79894788C>T	uc001vkz.2	-	22	3012	c.2998G>A	c.(2998-3000)GAG>AAG	p.E1000K	RBM26_uc001vky.2_Missense_Mutation_p.E971K|RBM26_uc001vla.2_Missense_Mutation_p.E974K|RBM26_uc010tia.1_3'UTR|RBM26_uc001vkx.2_Missense_Mutation_p.E710K	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	998					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TCATTGTCCTCTTCTTCTTCA	0.328													6	43					0	0	0	0	T	79894788	T	T	79894788	3	4	72	1	0	0	0	0	1	0	0	0	13191	922	32	2	35	2	RBM26	13	79894788	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	9438283	79894788	35275090	141	14843											
SLITRK6	84189	broad.mit.edu	37	chr13	86368921	86368921	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaactagtctgtgttggcaTggatgggttatttactaaac	10	15	11	5	0	1	0	0	0	1	0	1	1	1	1	0	3	3	4	0	3	6	7	rs34019808		TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr13:86368921T>C	uc001vll.1	-	2	2182	c.1723A>G	c.(1723-1725)ATG>GTG	p.M575V	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	575	Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TGTGTTGGCATGGATGGGTTA	0.448													18	78					0	0	0	0	C	86368921	C	C	86368921	3	2	72	1	0	0	0	0	1	0	0	0	14811	1464	51	5	806	5	SLITRK6	13	86368921	Missense_Mutation	SNP	T	TCGA-CN-6013-01A-11D-1683-08	6474133	86368921	28800957	142	14844											
ERCC5	2073	broad.mit.edu	37	chr13	103514661	103514661	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctccatatcaccccggactCtttcagccattaagagagct	10	10	7	14	1	3	1	2	0	1	1	4	3	4	2	4	1	2	2	4	1	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr13:103514661C>T	uc001vpw.2	+	8	1605	c.1162C>T	c.(1162-1164)CTT>TTT	p.L388F	ERCC5_uc001vpu.1_Missense_Mutation_p.L842F|ERCC5_uc010tjb.1_Missense_Mutation_p.L388F|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.L220F	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	388					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ACCCCGGACTCTTTCAGCCAT	0.532			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				12	39					0	0	0	0	T	103514661	T	T	103514661	3	4	72	1	0	0	0	0	1	0	0	0	5240	913	32	2	1192	2	ERCC5	13	103514661	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	17145740	103514661	11655217	143	14845											
NGDN	25983	broad.mit.edu	37	chr14	23940186	23940186	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcctatcctacagaaaaGgtaagatgtactcaaacagt	15	9	9	8	0	1	2	1	0	0	2	2	2	2	2	2	2	4	2	2	2	7	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr14:23940186G>A	uc001wjy.2	+	3	171	c.144G>A	c.(142-144)AAG>AAA	p.K48K	NGDN_uc001wjz.2_Silent_p.K48K	NM_001042635	NP_001036100	Q8NEJ9	NGDN_HUMAN	neuroguidin isoform 1	48	Necessary for interaction with EIF4E (By similarity).				regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus					0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		CTACAGAAAAGGTAAGATGTA	0.299													13	48					0	0	0	0	A	23940186	A	A	23940186	2	1	72	1	0	0	0	0	0	0	0	1	10447	1014	35	4		4	NGDN	14	23940186	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08		23940186	83409354	144	14846											
PRKD1	5587	broad.mit.edu	37	chr14	30095738	30095738	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acccagtacttcatcaggaaAaatctgatatactgtgctga	14	11	7	9	0	3	2	2	2	1	0	3	3	3	3	1	1	3	2	1	1	5	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr14:30095738A>T	uc001wqh.2	-	12	1931	c.1750T>A	c.(1750-1752)TTT>ATT	p.F584I		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	584	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TCATCAGGAAAAATCTGATAT	0.308													5	45					0	0	0	0	T	30095738	T	T	30095738	3	4	72	1	0	0	0	0	1	0	0	0	12580	14	1	5	1016	5	PRKD1	14	30095738	Missense_Mutation	SNP	A	TCGA-CN-6013-01A-11D-1683-08	6155552	30095738	77253802	145	14847											
MBIP	51562	broad.mit.edu	37	chr14	36780830	36780830	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgtagtcgttcttctacagCctgattaccacagtctcgaa	9	14	7	11	2	3	1	0	1	3	0	5	2	3	1	2	0	3	2	2	0	4	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr14:36780830C>A	uc001wtm.2	-	6	827	c.739G>T	c.(739-741)GCT>TCT	p.A247S	MBIP_uc001wto.2_Missense_Mutation_p.A247S|MBIP_uc010tpy.1_Missense_Mutation_p.A106S|MBIP_uc001wtn.2_Missense_Mutation_p.A247S	NM_016586	NP_057670	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1 isoform 1	247	Interaction with MAP3K12.				histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		TCTTCTACAGCCTGATTACCA	0.443													18	43					4.96729e-08	5.2523e-08	1	0	A	36780830	A	A	36780830	3	1	72	1	0	0	0	0	1	0	0	0	9402	739	26	4	311	4	MBIP	14	36780830	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	6685092	36780830	70568710	146	14848											
NID2	22795	broad.mit.edu	37	chr14	52496406	52496406	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccccggagtggggtctgaatCctctgcatgagtagagggga	8	8	16	9	1	2	3	0	2	2	1	3	5	3	5	3	5	1	2	3	5	2	1	rs17853445		TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr14:52496406C>G	uc001wzo.2	-	10	2494	c.2260G>C	c.(2260-2262)GAT>CAT	p.D754H	NID2_uc010tqs.1_Missense_Mutation_p.D754H|NID2_uc010tqt.1_Missense_Mutation_p.D754H|NID2_uc001wzp.2_Missense_Mutation_p.D754H	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	754	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GGGTCTGAATCCTCTGCATGA	0.502													4	31					0	0	0	0	G	52496406	G	G	52496406	3	3	72	1	0	0	0	0	1	0	0	0	10469	855	30	2	1919	2	NID2	14	52496406	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	15715576	52496406	54853134	147	14849											
SPTB	6710	broad.mit.edu	37	chr14	65262207	65262207	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtccttgcgggccgtgatgcGcttctggtcatggtagttct	3	14	14	10	3	3	1	1	1	2	0	4	1	4	1	2	3	2	3	2	3	1	4	rs144624027		TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr14:65262207G>A	uc001xht.2	-	11	1546	c.1492C>T	c.(1492-1494)CGC>TGC	p.R498C	SPTB_uc001xhr.2_Missense_Mutation_p.R498C|SPTB_uc001xhs.2_Missense_Mutation_p.R498C|SPTB_uc001xhu.2_Missense_Mutation_p.R498C	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	498	Spectrin 2.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GCCGTGATGCGCTTCTGGTCA	0.627													16	49					0	0	0	0	A	65262207	A	A	65262207	3	1	72	1	0	0	0	0	1	0	0	0	15184	1087	38	1	5663	1	SPTB	14	65262207	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	12765801	65262207	42087333	148	14850											
PCNX	22990	broad.mit.edu	37	chr14	71540300	71540300	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaagtggaggccattactGaaggtgtagaggaagatgaa	14	7	17	3	0	0	4	0	2	0	2	0	7	0	7	1	5	1	1	1	5	6	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr14:71540300G>A	uc001xmo.2	+	27	5337	c.4891G>A	c.(4891-4893)GAA>AAA	p.E1631K	PCNX_uc010are.1_Missense_Mutation_p.E1520K|PCNX_uc010arf.1_Missense_Mutation_p.E419K	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1631						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GGCCATTACTGAAGGTGTAGA	0.448													22	62					0	0	0	0	A	71540300	A	A	71540300	3	1	72	1	0	0	0	0	1	0	0	0	11645	1291	45	2	4997	2	PCNX	14	71540300	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	6278093	71540300	35809240	149	14851											
FBLN5	10516	broad.mit.edu	37	chr14	92403316	92403316	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattggttgctttcatccatCtggtatccaaagcggcatat	9	14	8	10	1	2	0	1	0	1	0	4	0	4	0	2	3	2	4	2	3	3	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr14:92403316C>T	uc001xzx.3	-	4	827	c.354G>A	c.(352-354)CAG>CAA	p.Q118Q	FBLN5_uc010aud.2_Silent_p.Q123Q|FBLN5_uc010aue.2_Silent_p.Q159Q	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	118					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				TTTCATCCATCTGGTATCCAA	0.507													26	81					0	0	0	0	T	92403316	T	T	92403316	2	4	72	1	0	0	0	0	0	0	0	1	5732	912	32	2		2	FBLN5	14	92403316	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	20863016	92403316	14946224	150	14852											
GANC	2595	broad.mit.edu	37	chr15	42584947	42584947	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctaggctgatttcatgctCtggggacacaggcagtctga	8	12	12	9	0	4	2	1	2	3	0	4	3	4	3	0	4	1	3	0	4	1	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr15:42584947C>G	uc001zpi.2	+	5	658	c.344C>G	c.(343-345)TCT>TGT	p.S115C	GANC_uc001zph.2_Missense_Mutation_p.S115C|GANC_uc001zpj.1_5'UTR	NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	115					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		ATTTCATGCTCTGGGGACACA	0.423													16	60					0	0	0	0	G	42584947	G	G	42584947	3	3	72	1	0	0	0	0	1	0	0	0	6269	913	32	2	362	2	GANC	15	42584947	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08		42584947	59946445	151	14853											
TP53BP1	7158	broad.mit.edu	37	chr15	43766895	43766895	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctcccttcttgctctgtggGactgctaggaacgataaaag	9	12	10	10	1	3	0	0	0	3	0	4	3	3	2	1	2	3	2	1	2	4	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr15:43766895G>A	uc001zrs.2	-	10	1289	c.1141C>T	c.(1141-1143)CCC>TCC	p.P381S	TP53BP1_uc010udp.1_Missense_Mutation_p.P381S|TP53BP1_uc001zrq.3_Missense_Mutation_p.P386S|TP53BP1_uc001zrr.3_Missense_Mutation_p.P386S|TP53BP1_uc010udq.1_Missense_Mutation_p.P386S	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	381					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TGCTCTGTGGGACTGCTAGGA	0.413								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					9	20					0	0	0	0	A	43766895	A	A	43766895	3	1	72	1	0	0	0	0	1	0	0	0	16450	1174	41	2	4853	2	TP53BP1	15	43766895	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	1181948	43766895	58764497	152	14854											
SMAD3	4088	broad.mit.edu	37	chr15	67482855	67482855	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatgggctccccaagcatccGctgttccagtgtgtcttaga	7	11	11	12	1	1	1	0	0	1	1	4	2	4	1	4	1	1	4	4	1	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr15:67482855G>A	uc002aqj.2	+	9	1557	c.1259G>A	c.(1258-1260)CGC>CAC	p.R420H	SMAD3_uc010ujr.1_Missense_Mutation_p.R315H|SMAD3_uc010ujs.1_Missense_Mutation_p.R376H|SMAD3_uc010ujt.1_Missense_Mutation_p.R225H	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	420	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CCAAGCATCCGCTGTTCCAGT	0.547													4	14					0	0	0	0	A	67482855	A	A	67482855	3	1	72	1	0	0	0	0	1	0	0	0	14823	1087	38	1	1371	1	SMAD3	15	67482855	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	23715960	67482855	35048537	153	14855											
IQCH	64799	broad.mit.edu	37	chr15	67664726	67664726	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccagatatgaccttctctCagtgttagaggacccagctc	10	11	8	12	0	2	3	1	1	1	2	4	4	2	4	3	1	2	2	3	1	3	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr15:67664726C>T	uc002aqo.1	+	9	1078	c.1031C>T	c.(1030-1032)TCA>TTA	p.S344L	IQCH_uc010ujv.1_Missense_Mutation_p.S163L|IQCH_uc002aqn.1_Missense_Mutation_p.S171L|IQCH_uc002aqq.1_Missense_Mutation_p.S92L|IQCH_uc002aqp.1_Missense_Mutation_p.S96L	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	344										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		GACCTTCTCTCAGTGTTAGAG	0.443													22	56					0	0	0	0	T	67664726	T	T	67664726	3	4	72	1	0	0	0	0	1	0	0	0	7850	838	29	2	1193	2	IQCH	15	67664726	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	181871	67664726	34866666	154	14856											
SGK269	79834	broad.mit.edu	37	chr15	77473608	77473608	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaacagaaccggcccccttCattactaatcacttctgtgc	10	11	6	14	1	3	1	2	0	1	1	3	1	3	1	3	1	4	1	3	1	4	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr15:77473608C>T	uc002bcm.2	-	3	969	c.661G>A	c.(661-663)GAA>AAA	p.E221K	SGK269_uc002bcn.2_Missense_Mutation_p.E221K	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	221					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		CGGCCCCCTTCATTACTAATC	0.473													29	137					0	0	0	0	T	77473608	T	T	77473608	3	4	72	1	0	0	0	0	1	0	0	0	14276	835	29	2	4595	2	SGK269	15	77473608	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	9808882	77473608	25057784	155	14857											
PRC1	9055	broad.mit.edu	37	chr15	91527353	91527353	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggctttcctcttcagcaatCatcatatccaggagttccta	10	13	6	12	0	4	0	3	0	1	0	7	1	7	1	3	2	1	3	3	2	3	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr15:91527353C>T	uc002bqm.2	-	3	319	c.162G>A	c.(160-162)ATG>ATA	p.M54I	PRC1_uc002bqn.2_Missense_Mutation_p.M54I|PRC1_uc002bqo.2_Missense_Mutation_p.M54I|PRC1_uc010uqs.1_Intron|PRC1_uc010uqt.1_Missense_Mutation_p.M2I	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	54	Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					CTTCAGCAATCATCATATCCA	0.428													50	274					0	0	0	0	T	91527353	T	T	91527353	3	4	72	1	0	0	0	0	1	0	0	0	12508	826	29	2	1752	2	PRC1	15	91527353	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	14053745	91527353	11004039	156	14858											
MEFV	4210	broad.mit.edu	37	chr16	3304662	3304662	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggctggcagctccgccccCgtacggccgagggccgttcc	4	5	14	18	5	0	0	0	0	0	0	2	1	2	0	6	4	2	5	6	4	1	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr16:3304662C>T	uc002cun.1	-	2	446	c.406G>A	c.(406-408)GGG>AGG	p.G136R		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	136					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	GCTCCGCCCCCGTACGGCCGA	0.701													5	31					0	0	0	0	T	3304662	T	T	3304662	3	4	72	1	0	0	0	0	1	0	0	0	9512	652	23	1	1975	1	MEFV	16	3304662	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08		3304662	87050091	157	14859											
ERCC4	2072	broad.mit.edu	37	chr16	14041533	14041533	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatgcgtgaatttcgaagtGagcttccatctctgatccat	10	14	8	9	2	1	3	0	3	1	0	5	4	3	3	2	0	2	1	2	0	3	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr16:14041533G>C	uc002dce.2	+	11	2089	c.2080G>C	c.(2080-2082)GAG>CAG	p.E694Q	ERCC4_uc010uyz.1_Missense_Mutation_p.E244Q	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	694	ERCC4.|Interaction with EME1 and ERCC1.				double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						ATTTCGAAGTGAGCTTCCATC	0.468			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				7	122					0	0	0	0	C	14041533	C	C	14041533	3	2	72	1	0	0	0	0	1	0	0	0	5239	1291	45	2	2122	2	ERCC4	16	14041533	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	10736871	14041533	76313220	158	14860											
DNAH3	55567	broad.mit.edu	37	chr16	20976685	20976685	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtcatatgtcttaagactctCcaagaatttcagatccccaa	13	12	5	11	0	4	3	2	0	2	3	6	3	5	3	3	0	0	0	3	0	5	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr16:20976685C>G	uc010vbe.1	-	53	8521	c.8521G>C	c.(8521-8523)GAG>CAG	p.E2841Q	DNAH3_uc010vbd.1_Missense_Mutation_p.E276Q	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2841	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTAAGACTCTCCAAGAATTTC	0.423													4	151					0	0	0	0	G	20976685	G	G	20976685	3	3	72	1	0	0	0	0	1	0	0	0	4625	864	30	2	3868	2	DNAH3	16	20976685	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	6935152	20976685	69378068	159	14861											
DNAH3	55567	broad.mit.edu	37	chr16	21069481	21069481	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagacacagataaccacctGtccaggccactgtaagaccc	13	5	9	14	0	0	3	0	0	0	3	1	4	1	3	5	2	1	1	5	2	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr16:21069481G>C	uc010vbe.1	-	27	3850	c.3850C>G	c.(3850-3852)CAG>GAG	p.Q1284E		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1284	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATAACCACCTGTCCAGGCCAC	0.483													8	48					0	0	0	0	C	21069481	C	C	21069481	3	2	72	1	0	0	0	0	1	0	0	0	4625	1386	48	4	8643	4	DNAH3	16	21069481	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	92796	21069481	69285272	160	14862											
ZNF785	146540	broad.mit.edu	37	chr16	30594258	30594258	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggggcagctgtagggcttctCgcccgtgtgcttgcgctggt	2	11	17	11	3	1	0	0	0	1	0	2	0	1	0	1	4	3	6	1	4	1	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr16:30594258C>T	uc002dyw.1	-	3	919	c.841G>A	c.(841-843)GAG>AAG	p.E281K	uc002dyu.2_RNA|ZNF785_uc002dyv.1_Missense_Mutation_p.E266K|ZNF785_uc010vez.1_Missense_Mutation_p.E246K	NM_152458	NP_689671	A8K8V0	ZN785_HUMAN	zinc finger protein 785	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAGGGCTTCTCGCCCGTGTGC	0.642													5	44					0	0	0	0	T	30594258	T	T	30594258	3	4	72	1	0	0	0	0	1	0	0	0	18224	893	31	1	380	1	ZNF785	16	30594258	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	9524777	30594258	59760495	161	14863											
STX4	6810	broad.mit.edu	37	chr16	31045559	31045559	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccccaggtccggacaattCggcagactattgtcaaactg	10	9	9	13	2	1	1	1	0	0	1	4	2	3	2	3	3	1	1	3	3	3	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr16:31045559C>T	uc002eal.2	+	3	369	c.145C>T	c.(145-147)CGG>TGG	p.R49W	STX4_uc002eak.2_Missense_Mutation_p.R47W|STX4_uc002eam.2_5'UTR	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	49	Cytoplasmic (Potential).|Potential.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						CCGGACAATTCGGCAGACTAT	0.577													34	179					0	0	0	0	T	31045559	T	T	31045559	3	4	72	1	0	0	0	0	1	0	0	0	15413	875	31	1	155	1	STX4	16	31045559	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	451301	31045559	59309194	162	14864											
CNGB1	1258	broad.mit.edu	37	chr16	57994394	57994394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctccctgtacctgggtctGaggcagcacctgtagcaact	7	9	10	15	0	1	1	0	1	1	0	2	1	2	1	4	2	4	5	4	2	3	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr16:57994394G>A	uc002emt.2	-	9	640	c.575C>T	c.(574-576)TCA>TTA	p.S192L	CNGB1_uc010cdh.2_Intron|CNGB1_uc002emu.2_Missense_Mutation_p.S192L	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	192	Pro-rich.			Missing (in Ref. 4; AAC04830).	sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						ACCTGGGTCTGAGGCAGCACC	0.647													3	20					0	0	0	0	A	57994394	A	A	57994394	3	1	72	1	0	0	0	0	1	0	0	0	3615	1294	45	2	3310	2	CNGB1	16	57994394	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	26948835	57994394	32360359	163	14865											
ZFHX3	463	broad.mit.edu	37	chr16	72821592	72821592	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcacgccaggcagtggtacGagccgccgccgccgccgccg	5	2	15	19	9	0	0	0	0	0	0	0	1	0	0	7	2	2	3	7	2	1	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr16:72821592G>A	uc002fck.2	-	10	11256	c.10583C>T	c.(10582-10584)TCG>TTG	p.S3528L	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Missense_Mutation_p.S2614L	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3528					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GCAGTGGTACGAgccgccgcc	0.393													11	26					0	0	0	0	A	72821592	A	A	72821592	3	1	72	1	0	0	0	0	1	0	0	0	17701	1059	37	1	532	1	ZFHX3	16	72821592	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	14827198	72821592	17533161	164	14866											
ZFHX3	463	broad.mit.edu	37	chr16	72992974	72992974	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaactgtgtccggggcctatGaggttagctgtggaaactaa	11	10	13	7	1	0	1	0	1	0	0	1	2	1	2	2	4	3	2	2	4	5	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr16:72992974G>A	uc002fck.2	-	2	1744	c.1071C>T	c.(1069-1071)CTC>CTT	p.L357L	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	357					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CGGGGCCTATGAGGTTAGCTG	0.507													24	77					0	0	0	0	A	72992974	A	A	72992974	2	1	72	1	0	0	0	0	0	0	0	1	17701	1277	45	2		2	ZFHX3	16	72992974	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	171382	72992974	17361779	165	14867											
SPG7	6687	broad.mit.edu	37	chr16	89619531	89619531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggaagcactgtccttcaacGaggtcacttctggtgaggag	9	9	13	10	2	3	1	2	1	1	0	4	4	4	3	1	4	2	1	1	4	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr16:89619531G>A	uc002fnj.2	+	14	1945	c.1924G>A	c.(1924-1926)GAG>AAG	p.E642K	SPG7_uc002fnk.1_RNA|SPG7_uc002fnl.2_Missense_Mutation_p.E51K	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	642	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GTCCTTCAACGAGGTCACTTC	0.602													3	10					0	0	0	0	A	89619531	A	A	89619531	3	1	72	1	0	0	0	0	1	0	0	0	15110	1059	37	1	2128	1	SPG7	16	89619531	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	16626557	89619531	735222	166	14868											
CAMKK1	84254	broad.mit.edu	37	chr17	3773161	3773161	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcttcaggatcaggtccttGagctcctcgctgatttctgg	6	14	10	11	1	4	2	2	2	2	0	7	3	6	3	2	3	1	2	2	3	0	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:3773161G>C	uc002fwt.2	-	13	1240	c.1146C>G	c.(1144-1146)CTC>CTG	p.L382L	CAMKK1_uc002fwu.2_Silent_p.L382L|CAMKK1_uc002fwv.2_Silent_p.L420L	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	382	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		TCAGGTCCTTGAGCTCCTCGC	0.587													9	40					0	0	0	0	C	3773161	C	C	3773161	2	2	72	1	0	0	0	0	0	0	0	1	2618	1277	45	2		2	CAMKK1	17	3773161	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08		3773161	77422049	167	14869											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	5	11	9	16	2	3	0	0	0	3	0	7	1	5	1	3	3	1	1	3	3	0	2	rs28934574		TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	29					0	0	0	0	A	7577094	A	A	7577094	3	1	72	1	0	0	0	0	1	0	0	0	16448	1115	39	1	442	1	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	3803933	7577094	73618116	168	14870											
RPL26	6154	broad.mit.edu	37	chr17	8285520	8285520	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgtacttctgtctcagctCtttggaaagaggggaagaca	10	12	12	7	0	3	2	1	0	3	2	4	4	3	4	0	3	2	3	0	3	3	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:8285520C>G	uc002glh.1	-	2	205	c.109G>C	c.(109-111)GAG>CAG	p.E37Q		NM_000987	NP_000978	P61254	RL26_HUMAN	ribosomal protein L26	37					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						TGTCTCAGCTCTTTGGAAAGA	0.448													9	48					0	0	0	0	G	8285520	G	G	8285520	3	3	72	1	0	0	0	0	1	0	0	0	13638	922	32	2	340	2	RPL26	17	8285520	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	708426	8285520	72909690	169	14871											
MYH10	4628	broad.mit.edu	37	chr17	8387530	8387530	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggattgagcaaaaatctCatctctggatgcacgagctt	11	13	9	8	1	2	1	1	1	2	0	4	4	2	3	0	2	3	3	0	2	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:8387530C>T	uc002gll.2	-	35	5104	c.5008G>A	c.(5008-5010)GAG>AAG	p.E1670K	MYH10_uc002glm.2_Missense_Mutation_p.E1701K|MYH10_uc010cnx.2_Missense_Mutation_p.E1679K	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1670	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GCAAAAATCTCATCTCTGGAT	0.373													11	71					0	0	0	0	T	8387530	T	T	8387530	3	4	72	1	0	0	0	0	1	0	0	0	10083	835	29	2	950	2	MYH10	17	8387530	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	102010	8387530	72807680	170	14872											
PIK3R5	23533	broad.mit.edu	37	chr17	8792140	8792140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcctcctcctcttcctcctCttcatcatctcccaggatcc	4	14	2	21	0	5	0	2	0	3	0	12	1	11	1	7	1	0	0	7	1	0	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:8792140C>T	uc002glt.2	-	10	1031	c.964G>A	c.(964-966)GAG>AAG	p.E322K	PIK3R5_uc010vuz.1_Missense_Mutation_p.E322K|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Silent_p.K270K|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	322				DILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGH CAERDSLLSTSSLASHDSTLSLASSQASG -> GNIEGDPG PRRPDSAGLASLQTSCRKSCSRNRSYSSQGSWEMMKRRERR RRRWRRTWKLTGTVPREIPCS (in Ref. 6; AAW63121).	platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						tcttcctcctcttcATCATCT	0.473													3	25					0	0	0	0	T	8792140	T	T	8792140	3	4	72	1	0	0	0	0	1	0	0	0	11977	922	32	2	1718	2	PIK3R5	17	8792140	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	404610	8792140	72403070	171	14873											
MYH1	4619	broad.mit.edu	37	chr17	10408181	10408181	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcatcagagtaaccattttTtcttccagctctttcctttt	7	19	4	11	0	3	1	1	0	2	1	5	1	5	1	3	0	3	3	3	0	1	8			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:10408181T>G	uc002gmo.2	-	22	2731	c.2637A>C	c.(2635-2637)GAA>GAC	p.E879D	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	879	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TAACCATTTTTTCTTCCAGCT	0.423													13	54					0	0	0	0	G	10408181	G	G	10408181	3	3	72	1	0	0	0	0	1	0	0	0	10082	1838	64	5	3258	5	MYH1	17	10408181	Missense_Mutation	SNP	T	TCGA-CN-6013-01A-11D-1683-08	1616041	10408181	70787029	172	14874											
ZNF287	57336	broad.mit.edu	37	chr17	16456726	16456726	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactggagtacatgcttgggCtttagtttcccattctgaaa	9	14	9	9	0	1	1	0	1	1	0	2	2	2	2	1	2	2	4	1	2	3	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:16456726C>A	uc002gqi.2	-	6	1183	c.730G>T	c.(730-732)GCC>TCC	p.A244S		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	237					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		CATGCTTGGGCTTTAGTTTCC	0.313													21	61					3.62473e-10	3.86438e-10	1	0	A	16456726	A	A	16456726	3	1	72	1	0	0	0	0	1	0	0	0	17892	797	28	4	1559	4	ZNF287	17	16456726	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	6048545	16456726	64738484	173	14875											
FLII	2314	broad.mit.edu	37	chr17	18155348	18155348	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacggtagcaggagaggcaCccgctagccgcagctggttc	8	5	14	14	3	0	1	0	0	0	1	1	2	0	1	3	4	3	7	3	4	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:18155348C>A	uc002gsr.1	-	11	1262	c.1211G>T	c.(1210-1212)GGT>GTT	p.G404V	FLII_uc002gsq.1_Missense_Mutation_p.G276V|FLII_uc010cpy.1_Missense_Mutation_p.G393V|FLII_uc010vxn.1_Missense_Mutation_p.G373V|FLII_uc010vxo.1_Missense_Mutation_p.G350V|FLII_uc002gss.1_Missense_Mutation_p.G404V	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	404	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					AGGAGAGGCACCCGCTAGCCG	0.637													11	57					5.03518e-11	5.41282e-11	1	0	A	18155348	A	A	18155348	3	1	72	1	0	0	0	0	1	0	0	0	5957	507	18	4	2678	4	FLII	17	18155348	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	1698622	18155348	63039862	174	14876											
SLC6A4	6532	broad.mit.edu	37	chr17	28548952	28548952	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacgctgatagctgcttctGagaattcaagggcgtcgtct	9	11	11	10	3	3	2	1	2	2	1	4	3	3	2	0	1	2	3	0	1	3	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:28548952G>C	uc002hey.3	-	3	569	c.25C>G	c.(25-27)CAG>GAG	p.Q9E		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	9	Cytoplasmic (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	AGCTGCTTCTGAGAATTCAAG	0.502													15	41					0	0	0	0	C	28548952	C	C	28548952	3	2	72	1	0	0	0	0	1	0	0	0	14750	1299	45	2	1919	2	SLC6A4	17	28548952	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	10393604	28548952	52646258	175	14877											
ACACA	31	broad.mit.edu	37	chr17	35614787	35614787	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttcctgagctgggcttaaaaCcctgttagagaataaagaat	14	11	9	7	0	0	3	0	1	0	2	1	4	1	3	2	1	2	3	2	1	7	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:35614787C>T	uc002hnm.2	-	14	1744	c.1553G>A	c.(1552-1554)GGT>GAT	p.G518D	ACACA_uc002hnk.2_Missense_Mutation_p.G440D|ACACA_uc002hnl.2_Missense_Mutation_p.G460D|ACACA_uc002hnn.2_Missense_Mutation_p.G518D|ACACA_uc002hno.2_Missense_Mutation_p.G555D|ACACA_uc010cuz.2_Missense_Mutation_p.G518D	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	518	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GGGCTTAAAACCCTGTTAGAG	0.388													16	53					0	0	0	0	T	35614787	T	T	35614787	3	4	72	1	0	0	0	0	1	0	0	0	106	521	18	4	5659	4	ACACA	17	35614787	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	7065835	35614787	45580423	176	14878											
BZRAP1	9256	broad.mit.edu	37	chr17	56382487	56382487	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcctcaggcccagggccctCcaggaagttggatggaacca	9	6	13	13	0	1	0	1	0	0	0	2	3	2	3	5	5	2	1	5	5	2	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:56382487C>T	uc002ivx.3	-	30	6350	c.5479G>A	c.(5479-5481)GAG>AAG	p.E1827K	BZRAP1_uc002ivv.2_Missense_Mutation_p.E57K|BZRAP1_uc002ivw.2_Missense_Mutation_p.E59K|BZRAP1_uc010dcs.2_Missense_Mutation_p.E1767K|BZRAP1_uc010wnt.1_Missense_Mutation_p.E1818K	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1827	SH3 3.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCAGGGCCCTCCAGGAAGTTG	0.637													8	38					0	0	0	0	T	56382487	T	T	56382487	3	4	72	1	0	0	0	0	1	0	0	0	1582	864	30	2	102	2	BZRAP1	17	56382487	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	20767700	56382487	24812723	177	14879											
CBX2	84733	broad.mit.edu	37	chr17	77758352	77758352	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcatgcccggggtgggtctCcttgcccgccacgccaccgc	3	6	14	18	4	1	0	0	0	1	0	2	0	1	0	6	4	2	1	6	4	0	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr17:77758352C>T	uc002jxc.2	+	5	1152	c.1110C>T	c.(1108-1110)CTC>CTT	p.L370L		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	370					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGGTGGGTCTCCTTGCCCGCC	0.697													4	27					0	0	0	0	T	77758352	T	T	77758352	2	4	72	1	0	0	0	0	0	0	0	1	2730	842	30	2		2	CBX2	17	77758352	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	21375865	77758352	3436858	178	14880											
THOC1	9984	broad.mit.edu	37	chr18	214778	214778	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttagctctcatcttcatgtCttcactgtcacactcaatct	8	16	3	14	0	8	0	5	0	4	0	9	0	8	0	0	0	1	1	0	0	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr18:214778C>A	uc002kkj.3	-	21	1862	c.1822G>T	c.(1822-1824)GAC>TAC	p.D608Y	THOC1_uc002kkk.3_RNA|THOC1_uc002kkh.3_Missense_Mutation_p.D232Y	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	THO complex 1	608	Death.				apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				ATCTTCATGTCTTCACTGTCA	0.448													14	62					1.3612e-06	1.43343e-06	1	0	A	214778	A	A	214778	3	1	72	1	0	0	0	0	1	0	0	0	15930	913	32	2	155	2	THOC1	18	214778	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08		214778	77862470	179	14881											
LPIN2	9663	broad.mit.edu	37	chr18	2931287	2931287	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccattttcactgaggccccCgcaaagggagagggtaacgt	10	8	12	11	2	1	2	1	1	0	1	2	3	2	2	3	3	1	2	3	3	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr18:2931287C>T	uc002klo.2	-	9	1662	c.1423G>A	c.(1423-1425)GGG>AGG	p.G475R		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	475					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		CTGAGGCCCCCGCAAAGGGAG	0.522													7	24					0	0	0	0	T	2931287	T	T	2931287	3	4	72	1	0	0	0	0	1	0	0	0	8969	652	23	1	1315	1	LPIN2	18	2931287	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	2716509	2931287	75145961	180	14882											
CXXC1	30827	broad.mit.edu	37	chr18	47810778	47810778	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttcatgccacagtcatctGagcaatacttggagctgggc	9	10	11	11	0	3	1	2	1	1	0	3	2	3	2	1	2	4	3	1	2	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr18:47810778G>A	uc002leq.3	-	9	1908	c.1175C>T	c.(1174-1176)TCA>TTA	p.S392L	MBD1_uc002leg.2_5'Flank|MBD1_uc010dow.1_5'Flank|MBD1_uc002leh.3_5'Flank|MBD1_uc002len.2_5'Flank|MBD1_uc002lei.3_5'Flank|MBD1_uc002lej.3_5'Flank|MBD1_uc002lek.3_5'Flank|MBD1_uc002lel.3_5'Flank|MBD1_uc002lem.3_5'Flank|MBD1_uc010xdj.1_5'Flank|MBD1_uc010xdk.1_5'Flank|MBD1_uc002leo.2_5'Flank|CXXC1_uc002lep.3_Missense_Mutation_p.S249L|CXXC1_uc002ler.3_Missense_Mutation_p.S396L|CXXC1_uc010doy.2_Missense_Mutation_p.S392L|CXXC1_uc002les.2_Missense_Mutation_p.S392L	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	392					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						ACAGTCATCTGAGCAATACTT	0.602													14	65					0	0	0	0	A	47810778	A	A	47810778	3	1	72	1	0	0	0	0	1	0	0	0	4114	1294	45	2	823	2	CXXC1	18	47810778	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	44879491	47810778	30266470	181	14883											
WDR7	23335	broad.mit.edu	37	chr18	54547249	54547249	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacggaagcaagctaccgctAttgttttacttggagtaata	12	12	10	7	2	0	0	0	0	0	0	0	3	0	2	1	2	4	5	1	2	7	8			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr18:54547249A>G	uc002lgk.1	+	21	3590	c.3379A>G	c.(3379-3381)ATT>GTT	p.I1127V	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.I1094V	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1127										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		AGCTACCGCTATTGTTTTACT	0.398													13	46					0	0	0	0	G	54547249	G	G	54547249	3	3	72	1	0	0	0	0	1	0	0	0	17388	449	16	5	3457	5	WDR7	18	54547249	Missense_Mutation	SNP	A	TCGA-CN-6013-01A-11D-1683-08	6736471	54547249	23529999	182	14884											
FUT5	2527	broad.mit.edu	37	chr19	5866613	5866613	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggccccatgccggcctctCaggtgaaccaagccgctatg	8	6	11	16	2	1	1	1	1	1	0	2	1	1	1	6	3	3	1	6	3	3	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:5866613C>T	uc002mdo.3	-	2	1212	c.1124G>A	c.(1123-1125)TGA>TAA	p.*375*	FUT5_uc010duo.2_Silent_p.*375*	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	375					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						GCCGGCCTCTCAGGTGAACCA	0.632													17	85					0	0	0	0	T	5866613	T	T	5866613	2	4	72	1	0	0	0	0	0	0	0	1	6141	837	29	2		2	FUT5	19	5866613	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08		5866613	53262370	183	14885											
ZNF557	79230	broad.mit.edu	37	chr19	7076392	7076392	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgatgtttgcaatgctttagGgcttggtgacctttgaggat	7	16	13	5	0	0	3	0	3	0	0	0	4	0	4	1	3	2	4	1	3	2	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:7076392G>A	uc002mgb.2	+	5	585	c.100G>A	c.(100-102)GGC>AGC	p.G34S	ZNF557_uc002mga.2_Missense_Mutation_p.G41S|ZNF557_uc002mgc.2_Missense_Mutation_p.G41S	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	34					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)		AATGCTTTAGGGCTTGGTGAC	0.582													13	64					0	0	0	0	A	7076392	A	A	7076392	3	1	72	1	0	0	0	0	1	0	0	0	18055	1246	43	4	131	4	ZNF557	19	7076392	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	1209779	7076392	52052591	184	14886											
LPHN1	22859	broad.mit.edu	37	chr19	14288437	14288437	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcttgtcgtccgtgcgccCgtagttggcattctccacca	6	12	9	14	4	2	0	0	0	2	0	5	0	3	0	4	1	1	3	4	1	2	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:14288437C>T	uc010xnn.1	-	3	486	c.190G>A	c.(190-192)GGG>AGG	p.G64R	LPHN1_uc010xno.1_Missense_Mutation_p.G64R	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	64	SUEL-type lectin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						TCCGTGCGCCCGTAGTTGGCA	0.607													22	83					0	0	0	0	T	14288437	T	T	14288437	3	4	72	1	0	0	0	0	1	0	0	0	8965	652	23	1	4322	1	LPHN1	19	14288437	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	7212045	14288437	44840546	185	14887											
ZNF333	84449	broad.mit.edu	37	chr19	14829870	14829870	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagtgagccctcatccctCaggaaacatgcaaggactca	12	8	8	13	0	4	1	4	1	0	0	5	3	5	3	2	2	3	1	2	2	2	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:14829870C>T	uc002mzn.2	+	12	1865	c.1731C>T	c.(1729-1731)CTC>CTT	p.L577L	ZNF333_uc002mzk.3_Silent_p.L468L	NM_032433	NP_115809	Q96JL9	ZN333_HUMAN	zinc finger protein 333	577	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCTCATCCCTCAGGAAACATG	0.522													8	35					0	0	0	0	T	14829870	T	T	14829870	2	4	72	1	0	0	0	0	0	0	0	1	17917	813	29	2		2	ZNF333	19	14829870	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	541433	14829870	44299113	186	14888											
ZNF91	7644	broad.mit.edu	37	chr19	23545292	23545292	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgaatttaaaaatttataGaagactttcaaatatttccc	16	17	3	5	0	1	3	1	1	0	2	2	3	2	3	1	0	0	0	1	0	9	9			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:23545292G>A	uc002nre.2	-	4	602	c.489C>T	c.(487-489)TTC>TTT	p.F163F	ZNF91_uc010xrj.1_Silent_p.F131F	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	163	C2H2-type 1; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AAAATTTATAGAAGACTTTCA	0.323													15	38					0	0	0	0	A	23545292	A	A	23545292	2	1	72	1	0	0	0	0	0	0	0	1	18267	933	33	2		2	ZNF91	19	23545292	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	8715422	23545292	35583691	187	14889											
ZNF527	84503	broad.mit.edu	37	chr19	37879380	37879380	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagctacatcagggaaatgcGgagaggcatttcatgcaagt	13	8	13	7	1	2	1	2	0	0	1	2	4	2	2	0	3	4	3	0	3	3	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:37879380G>A	uc010efk.1	+	5	540	c.429G>A	c.(427-429)GCG>GCA	p.A143A	ZNF527_uc002ogf.3_Silent_p.A111A|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGGGAAATGCGGAGAGGCATT	0.428													18	40					0	0	0	0	A	37879380	A	A	37879380	2	1	72	1	0	0	0	0	0	0	0	1	18035	1103	39	1		1	ZNF527	19	37879380	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	14334088	37879380	21249603	188	14890											
ZFP36	7538	broad.mit.edu	37	chr19	39898933	39898933	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcttctccggcctgccctCtggccgccggacctcaccac	4	7	9	21	3	3	0	1	0	2	0	4	1	3	1	7	3	2	1	7	3	0	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:39898933C>G	uc002olh.1	+	2	633	c.575C>G	c.(574-576)TCT>TGT	p.S192C	ZFP36_uc010egn.1_Missense_Mutation_p.L65V	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	192					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGCCTGCCCTCTGGCCGCCGG	0.692													33	103					0	0	0	0	G	39898933	G	G	39898933	3	3	72	1	0	0	0	0	1	0	0	0	17712	913	32	2	581	2	ZFP36	19	39898933	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	2019553	39898933	19230050	189	14891											
ADCK4	79934	broad.mit.edu	37	chr19	41209472	41209472	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagggccgcgctcatcttgAgtaccgccagcaggttctgg	6	8	14	13	3	3	1	1	1	2	0	3	1	3	1	3	3	2	5	3	3	1	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:41209472A>C	uc002oor.2	-	9	1075	c.773T>G	c.(772-774)CTC>CGC	p.L258R	ADCK4_uc002oop.1_5'Flank|ADCK4_uc002ooq.1_Missense_Mutation_p.L217R	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	258	Protein kinase.					integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GCTCATCTTGAGTACCGCCAG	0.622													9	24					0	0	0	0	C	41209472	C	C	41209472	3	2	72	1	0	0	0	0	1	0	0	0	290	304	11	5	889	5	ADCK4	19	41209472	Missense_Mutation	SNP	A	TCGA-CN-6013-01A-11D-1683-08	1310539	41209472	17919511	190	14892											
TMEM145	284339	broad.mit.edu	37	chr19	42822026	42822026	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcccttctttgctgcctatAccctctggtgagaattggtg	5	15	10	11	0	2	1	0	1	2	1	2	2	2	1	3	2	4	1	3	2	3	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:42822026A>C	uc002otk.1	+	12	1118	c.1066A>C	c.(1066-1068)ACC>CCC	p.T356P		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	356	Helical; (Potential).					integral to membrane					0		Prostate(69;0.00682)				TGCTGCCTATACCCTCTGGTG	0.557													7	44					0	0	0	0	C	42822026	C	C	42822026	3	2	72	1	0	0	0	0	1	0	0	0	16125	391	14	5	1112	5	TMEM145	19	42822026	Missense_Mutation	SNP	A	TCGA-CN-6013-01A-11D-1683-08	1612554	42822026	16306957	191	14893											
NLRP13	126204	broad.mit.edu	37	chr19	56436023	56436023	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catccctgggtctgcatattCcctgaaataaacattgacga	12	11	7	11	1	1	2	0	2	1	0	3	3	3	2	2	1	2	1	2	1	4	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:56436023C>T	uc010ygg.1	-	3	415	c.390G>A	c.(388-390)GGG>GGA	p.G130G		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	130							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TCTGCATATTCCCTGAAATAA	0.418													10	41					0	0	0	0	T	56436023	T	T	56436023	2	4	72	1	0	0	0	0	0	0	0	1	10529	869	30	2		2	NLRP13	19	56436023	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	13613997	56436023	2692960	192	14894											
ZNF549	256051	broad.mit.edu	37	chr19	58046527	58046527	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagggccatgtgacctttGaggatattgctgtgtacttc	7	14	12	8	0	0	2	0	2	0	0	1	3	0	3	2	2	3	3	2	2	2	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr19:58046527G>A	uc002qpb.1	+	3	337	c.88G>A	c.(88-90)GAG>AAG	p.E30K	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Missense_Mutation_p.E30K|ZNF549_uc002qpa.1_Missense_Mutation_p.E17K	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	30	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGTGACCTTTGAGGATATTGC	0.502													10	45					0	0	0	0	A	58046527	A	A	58046527	3	1	72	1	0	0	0	0	1	0	0	0	18048	1291	45	2	55	2	ZNF549	19	58046527	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	1610504	58046527	1082456	193	14895											
TGM3	7053	broad.mit.edu	37	chr20	2293573	2293573	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacattctcagcatctgcctCtcaatcttggataggagtct	9	13	8	11	0	5	0	2	0	5	0	7	3	5	2	1	2	2	1	1	2	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr20:2293573C>T	uc002wfx.3	+	5	667	c.570C>T	c.(568-570)CTC>CTT	p.L190L		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	190					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	GCATCTGCCTCTCAATCTTGG	0.478													9	193					0	0	0	0	T	2293573	T	T	2293573	2	4	72	1	0	0	0	0	0	0	0	1	15897	900	32	2		2	TGM3	20	2293573	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08		2293573	60731947	194	14896											
JAG1	182	broad.mit.edu	37	chr20	10620404	10620404	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcataatccttgatggggacCgtgttggccccatgtttctc	6	14	10	11	1	2	1	1	1	1	0	4	2	3	2	4	3	0	2	4	3	1	4			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr20:10620404C>T	uc002wnw.2	-	26	3915	c.3399G>A	c.(3397-3399)ACG>ACA	p.T1133T		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	1133	Cytoplasmic (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						TGATGGGGACCGTGTTGGCCC	0.483									Alagille_Syndrome				29	50					0	0	0	0	T	10620404	T	T	10620404	2	4	72	1	0	0	0	0	0	0	0	1	7973	639	23	1		1	JAG1	20	10620404	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	8326831	10620404	52405116	195	14897											
PCSK2	5126	broad.mit.edu	37	chr20	17462559	17462559	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagggggtgctgaaggagtgGaccctgatgctgcatggcac	9	7	17	8	0	0	2	0	2	0	0	0	4	0	4	1	5	3	4	1	5	2	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr20:17462559G>A	uc002wpm.2	+	12	2081	c.1761G>A	c.(1759-1761)TGG>TGA	p.W587*	PCSK2_uc002wpl.2_Nonsense_Mutation_p.W568*|PCSK2_uc010zrm.1_Nonsense_Mutation_p.W552*|PCSK2_uc002wpn.2_Nonsense_Mutation_p.W241*	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	587					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGAAGGAGTGGACCCTGATGC	0.622													4	32					0	0	0	0	A	17462559	A	A	17462559	4	1	72	1	0	0	0	0	0	1	0	0	11655	1183	41	2	1807	2	PCSK2	20	17462559	Nonsense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	6842155	17462559	45562961	196	14898											
CEP250	11190	broad.mit.edu	37	chr20	34067178	34067178	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccctagtacgagagaaagcGgctctagaggtgcggctgca	10	6	15	10	3	1	2	0	0	1	2	1	4	1	2	1	3	4	4	1	3	4	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr20:34067178G>A	uc002xcm.2	+	19	2888	c.2217G>A	c.(2215-2217)GCG>GCA	p.A739A	CEP250_uc010zve.1_Silent_p.A107A	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	739	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GAGAGAAAGCGGCTCTAGAGG	0.612													5	150					0	0	0	0	A	34067178	A	A	34067178	2	1	72	1	0	0	0	0	0	0	0	1	3267	1103	39	1		1	CEP250	20	34067178	Silent	SNP	G	TCGA-CN-6013-01A-11D-1683-08	16604619	34067178	28958342	197	14899											
SYS1	90196	broad.mit.edu	37	chr20	43995543	43995543	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgctgtacttcatccggCgaggaaagcagtgtctggat	8	11	13	9	2	2	0	1	0	1	0	3	3	3	2	1	3	3	4	1	3	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr20:43995543C>T	uc002xnv.2	+	4	517	c.259C>T	c.(259-261)CGA>TGA	p.R87*	SYS1_uc010gha.2_RNA|SYS1_uc002xnw.1_Intron|SYS1-DBNDD2_uc002xnx.2_Intron	NM_033542	NP_291020	Q8N2H4	SYS1_HUMAN	SYS1 Golgi-localized integral membrane protein	87					protein transport	Golgi membrane|integral to membrane				skin(1)	1		Myeloproliferative disorder(115;0.0122)				CTTCATCCGGCGAGGAAAGCA	0.567													65	92					0	0	0	0	T	43995543	T	T	43995543	4	4	72	1	0	0	0	0	0	1	0	0	15530	760	27	1	269	1	SYS1	20	43995543	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	9928365	43995543	19029977	198	14900											
SLC12A5	57468	broad.mit.edu	37	chr20	44663637	44663637	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatcaacagcaccgacacaGagaagggaaaggagtatgat	17	5	11	8	1	2	2	2	1	0	1	2	6	2	4	1	2	2	2	1	2	4	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr20:44663637G>A	uc010zxl.1	+	2	248	c.172G>A	c.(172-174)GAG>AAG	p.E58K	SLC12A5_uc002xra.2_Missense_Mutation_p.E35K|SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.E35K	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	58	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CACCGACACAGAGAAGGGAAA	0.517													13	74					0	0	0	0	A	44663637	A	A	44663637	3	1	72	1	0	0	0	0	1	0	0	0	14451	943	33	2	234	2	SLC12A5	20	44663637	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	668094	44663637	18361883	199	14901											
DNAJC5	80331	broad.mit.edu	37	chr20	62562255	62562255	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgctactgctgctgctgtCtgtgctgctgcttcaactgc	3	14	11	13	0	2	0	1	0	1	0	2	0	2	0	0	0	10	8	0	0	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr20:62562255C>T	uc002yhf.2	+	4	543	c.373C>T	c.(373-375)CTG>TTG	p.L125L	DNAJC5_uc002yhg.1_Silent_p.L125L|DNAJC5_uc002yhh.2_RNA	NM_025219	NP_079495	Q9H3Z4	DNJC5_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	125	Poly-Cys.				neurotransmitter secretion|protein folding	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|melanosome|plasma membrane	heat shock protein binding|unfolded protein binding			pancreas(1)	1	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					ctgctgctgtctgtgctgctg	0.483													5	68					0	0	0	0	T	62562255	T	T	62562255	2	4	72	1	0	0	0	0	0	0	0	1	4672	912	32	2		2	DNAJC5	20	62562255	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	17898618	62562255	463265	200	14902											
NCAM2	4685	broad.mit.edu	37	chr21	22881273	22881273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgtcagctgcttctttattCggcaatgtgggttgctgatg	6	15	12	8	2	2	1	1	1	1	0	3	1	2	1	0	2	3	5	0	2	2	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr21:22881273C>T	uc002yld.1	+	16	2428	c.2179C>T	c.(2179-2181)CGG>TGG	p.R727W	NCAM2_uc011acb.1_Missense_Mutation_p.R585W	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	727	Cytoplasmic (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CTTCTTTATTCGGCAATGTGG	0.468													13	42					0	0	0	0	T	22881273	T	T	22881273	3	4	72	1	0	0	0	0	1	0	0	0	10257	875	31	1	2241	1	NCAM2	21	22881273	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08		22881273	25248622	201	14903											
DSCAM	1826	broad.mit.edu	37	chr21	41414523	41414523	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttgctcttccatcttggCgtgttcgtaggccctggcca	4	13	11	13	2	2	0	0	0	2	0	4	0	3	0	3	3	1	4	3	3	1	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr21:41414523C>T	uc002yyq.1	-	32	5913	c.5461G>A	c.(5461-5463)GCC>ACC	p.A1821T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1821	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCCATCTTGGCGTGTTCGTAG	0.517													13	50					0	0	0	0	T	41414523	T	T	41414523	3	4	72	1	0	0	0	0	1	0	0	0	4790	768	27	1	585	1	DSCAM	21	41414523	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	18533250	41414523	6715372	202	14904											
MX1	4599	broad.mit.edu	37	chr21	42817972	42817972	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcactgctctcatgcaaggaGaggaaactgtaggggaggaa	13	7	14	7	0	2	1	2	0	1	1	3	5	2	4	0	5	3	3	0	5	4	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr21:42817972G>C	uc002yzh.2	+	15	2124	c.1177G>C	c.(1177-1179)GAG>CAG	p.E393Q	MX1_uc002yzi.2_Missense_Mutation_p.E393Q|MX1_uc010goq.2_Missense_Mutation_p.E393Q	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	393					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				CATGCAAGGAGAGGAAACTGT	0.398													8	33					0	0	0	0	C	42817972	C	C	42817972	3	2	72	1	0	0	0	0	1	0	0	0	10050	943	33	2	1211	2	MX1	21	42817972	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	1403449	42817972	5311923	203	14905											
COL6A1	1291	broad.mit.edu	37	chr21	47404200	47404200	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggtactaccgctgtgaccGaaacctggtgtggaacgcag	10	7	13	11	3	0	1	0	1	0	0	0	3	0	2	3	3	4	3	3	3	4	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr21:47404200G>A	uc002zhu.1	+	3	347	c.245G>A	c.(244-246)CGA>CAA	p.R82Q		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	82	VWFA 1.|N-terminal globular domain.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CGCTGTGACCGAAACCTGGTG	0.682													4	4					0	0	0	0	A	47404200	A	A	47404200	3	1	72	1	0	0	0	0	1	0	0	0	3714	1058	37	1	255	1	COL6A1	21	47404200	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	4586228	47404200	725695	204	14906											
OSBP2	23762	broad.mit.edu	37	chr22	31266528	31266528	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcagcacgtgcaatgacctCatcgccaagcacggcgctgc	9	6	10	16	4	2	1	2	1	0	0	3	1	2	1	2	1	4	4	2	1	2	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr22:31266528C>T	uc003aiy.1	+	3	1070	c.966C>T	c.(964-966)CTC>CTT	p.L322L	OSBP2_uc011ala.1_Silent_p.L157L|OSBP2_uc010gwc.1_Silent_p.L149L|OSBP2_uc003aix.1_Silent_p.L322L|OSBP2_uc011alb.1_Silent_p.L322L|OSBP2_uc003aiz.1_Silent_p.L322L|OSBP2_uc003aja.1_5'UTR|OSBP2_uc011alc.1_Silent_p.L64L	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	322					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						GCAATGACCTCATCGCCAAGC	0.587													6	22					0	0	0	0	T	31266528	T	T	31266528	2	4	72	1	0	0	0	0	0	0	0	1	11328	813	29	2		2	OSBP2	22	31266528	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08		31266528	20038038	205	14907											
MYH9	4627	broad.mit.edu	37	chr22	36702049	36702049	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acggatgccctcgagaacacCgttgcagcgcagctggtcca	9	6	12	14	4	0	1	0	0	0	1	2	3	1	2	3	2	5	4	3	2	1	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr22:36702049C>T	uc003apg.2	-	17	2317	c.2086G>A	c.(2086-2088)GGT>AGT	p.G696S	MYH9_uc003aph.1_Missense_Mutation_p.G560S	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	696	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TCGAGAACACCGTTGCAGCGC	0.627			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				18	55					0	0	0	0	T	36702049	T	T	36702049	3	4	72	1	0	0	0	0	1	0	0	0	10095	652	23	1	3896	1	MYH9	22	36702049	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	5435521	36702049	14602517	206	14908											
IL2RB	3560	broad.mit.edu	37	chr22	37539602	37539602	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttggcaggaagtgtcctgCagagccccatcttggctcca	8	9	11	13	0	1	1	0	0	1	1	3	2	3	2	4	3	2	3	4	3	1	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr22:37539602C>T	uc003aqv.1	-	3	293	c.162G>A	c.(160-162)CTG>CTA	p.L54L		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	54	Extracellular (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	AAGTGTCCTGCAGAGCCCCAT	0.562													15	41					0	0	0	0	T	37539602	T	T	37539602	2	4	72	1	0	0	0	0	0	0	0	1	7726	697	25	4		4	IL2RB	22	37539602	Silent	SNP	C	TCGA-CN-6013-01A-11D-1683-08	837553	37539602	13764964	207	14909											
IL2RB	3560	broad.mit.edu	37	chr22	37539642	37539642	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agacacaggagatgttggctCtcgagttgtagaagcatgtg	11	10	14	6	1	1	3	0	0	1	3	2	5	1	3	0	2	1	5	0	2	2	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr22:37539642C>G	uc003aqv.1	-	3	253	c.122G>C	c.(121-123)AGA>ACA	p.R41T		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	41	Extracellular (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GATGTTGGCTCTCGAGTTGTA	0.602													14	56					0	0	0	0	G	37539642	G	G	37539642	3	3	72	1	0	0	0	0	1	0	0	0	7726	913	32	2	1565	2	IL2RB	22	37539642	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	40	37539642	13764924	208	14910											
SUN2	25777	broad.mit.edu	37	chr22	39138356	39138356	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctccttcagggcagcttCacggcggctcactagcccct	6	9	9	17	2	3	0	3	0	0	0	5	0	5	0	4	3	2	3	4	3	1	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr22:39138356C>A	uc003awh.1	-	10	1302	c.1018G>T	c.(1018-1020)GAA>TAA	p.E340*	SUN2_uc011anz.1_Nonsense_Mutation_p.E375*|SUN2_uc011aoa.1_Nonsense_Mutation_p.E329*|SUN2_uc003awi.1_Nonsense_Mutation_p.E340*|SUN2_uc010gxq.1_Nonsense_Mutation_p.E361*|SUN2_uc010gxr.1_Nonsense_Mutation_p.E340*|SUN2_uc010gxs.1_Nonsense_Mutation_p.E340*	NM_015374	NP_056189	Q9UH99	SUN2_HUMAN	unc-84 homolog B	340	Perinuclear space.				centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			large_intestine(1)|skin(1)	2						AGGGCAGCTTCACGGCGGCTC	0.642													5	36					0.000157383	0.000165061	1	0	A	39138356	A	A	39138356	4	1	72	1	0	0	0	0	0	1	0	0	15458	835	29	2	1175	2	SUN2	22	39138356	Nonsense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	1598714	39138356	12166210	209	14911											
FAM19A5	25817	broad.mit.edu	37	chr22	49103655	49103655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggaggataaagaccaccaCggtatgtggccctcggcttt	9	8	13	11	3	0	1	0	0	0	1	1	3	0	3	3	5	0	2	3	5	3	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr22:49103655C>T	uc003bim.3	+	3	506	c.389C>T	c.(388-390)ACG>ATG	p.T130M	FAM19A5_uc003bio.3_Missense_Mutation_p.T123M	NM_001082967	NP_001076436	Q7Z5A7	F19A5_HUMAN	family with sequence similarity 19 (chemokine	130						extracellular region|integral to membrane				large_intestine(1)	1		all_cancers(38;2.95e-11)|all_epithelial(38;3.07e-10)|all_lung(38;2.89e-05)|Breast(42;0.000396)|Lung NSC(38;0.000471)|Ovarian(80;0.00934)|Lung SC(80;0.195)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0227)|BRCA - Breast invasive adenocarcinoma(115;0.119)		AAGACCACCACGGTATGTGGC	0.657													55	71					0	0	0	0	T	49103655	T	T	49103655	3	4	72	1	0	0	0	0	1	0	0	0	5563	550	19	1	494	1	FAM19A5	22	49103655	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	9965299	49103655	2200911	210	14912											
SHANK3	85358	broad.mit.edu	37	chr22	51160628	51160628	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcctctgccgggctggcctCtgccgccgggcctgcccgcc	0	6	14	21	5	2	0	0	0	2	0	2	0	2	0	8	3	3	1	8	3	0	0			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chr22:51160628C>G	uc003bne.1	+	22	4415	c.4415C>G	c.(4414-4416)TCT>TGT	p.S1472C	SHANK3_uc003bnf.1_Missense_Mutation_p.S919C|SHANK3_uc010hbg.1_Missense_Mutation_p.S654C	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1472										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		GGGCTGGCCTCTGCCGCCGGG	0.711													4	21					0	0	0	0	G	51160628	G	G	51160628	3	3	72	1	0	0	0	0	1	0	0	0	14331	913	32	2	4501	2	SHANK3	22	51160628	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	2056973	51160628	143938	211	14913											
PTCHD1	139411	broad.mit.edu	37	chrX	23412249	23412249	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaggaaattgagtgtgtaGaaatggtagatatcgatagt	14	11	15	1	1	0	3	0	1	0	2	1	6	0	5	0	3	0	2	0	3	6	5			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chrX:23412249G>A	uc004dal.3	+	3	2622	c.2614G>A	c.(2614-2616)GAA>AAA	p.E872K		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	872					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						TGAGTGTGTAGAAATGGTAGA	0.398													37	27					0	0	0	0	A	23412249	A	A	23412249	3	1	72	1	0	0	0	0	1	0	0	0	12794	943	33	2	2624	2	PTCHD1	23	23412249	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08		23412249	131858311	212	14914											
PCDH11X	27328	broad.mit.edu	37	chrX	91873419	91873419	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgctctatgccacagccCaccactgtcacaggcctcta	8	9	6	18	0	4	0	1	0	3	0	4	0	4	0	4	1	3	1	4	1	2	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chrX:91873419C>T	uc004efk.1	+	7	4369	c.3524C>T	c.(3523-3525)CCA>CTA	p.P1175L	PCDH11X_uc004efl.1_Missense_Mutation_p.P1165L|PCDH11X_uc004efo.1_Missense_Mutation_p.P1138L|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.P1167L|PCDH11X_uc004efn.1_Missense_Mutation_p.P1157L	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1175	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TGCCACAGCCCACCACTGTCA	0.567													16	43					0	0	0	0	T	91873419	T	T	91873419	3	4	72	1	0	0	0	0	1	0	0	0	11562	594	21	4	3672	4	PCDH11X	23	91873419	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	68461170	91873419	63397141	213	14915											
COL4A5	1287	broad.mit.edu	37	chrX	107834353	107834353	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggggtcagaaaggtgatGaaggaccacctggaatttcc	14	7	13	7	0	1	3	1	2	0	1	2	5	2	5	3	5	0	0	3	5	4	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chrX:107834353G>A	uc004enz.1	+	20	1433	c.1231G>A	c.(1231-1233)GAA>AAA	p.E411K	COL4A5_uc011mso.1_Missense_Mutation_p.E411K|COL4A5_uc004eob.1_Missense_Mutation_p.E19K	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	411	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GAAAGGTGATGAAGGACCACC	0.547									Alport_syndrome_with_Diffuse_Leiomyomatosis				30	61					0	0	0	0	A	107834353	A	A	107834353	3	1	72	1	0	0	0	0	1	0	0	0	3709	1291	45	2	1309	2	COL4A5	23	107834353	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	15960934	107834353	47436207	214	14916											
ODZ1	10178	broad.mit.edu	37	chrX	123775674	123775674	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatcctgtccacttgggatCacagctgcatactccagcgt	9	10	9	13	1	1	1	1	0	0	1	4	2	4	2	3	1	4	2	3	1	1	2			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chrX:123775674C>T	uc004euj.2	-	11	2108	c.2044G>A	c.(2044-2046)GAT>AAT	p.D682N	ODZ1_uc011muj.1_Missense_Mutation_p.D681N|ODZ1_uc010nqy.2_Missense_Mutation_p.D682N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	682	EGF-like 5.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CACTTGGGATCACAGCTGCAT	0.473													24	90					0	0	0	0	T	123775674	T	T	123775674	3	4	72	1	0	0	0	0	1	0	0	0	10888	826	29	2	6242	2	ODZ1	23	123775674	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	15941321	123775674	31494886	215	14917											
ODZ1	10178	broad.mit.edu	37	chrX	123775763	123775763	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtggtgtttcacagttaactCctccccagccagtagaacag	10	10	9	12	0	1	1	1	0	0	1	3	1	3	1	4	1	3	3	4	1	3	3			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chrX:123775763C>A	uc004euj.2	-	11	2019	c.1955G>T	c.(1954-1956)GGA>GTA	p.G652V	ODZ1_uc011muj.1_Missense_Mutation_p.G651V|ODZ1_uc010nqy.2_Missense_Mutation_p.G652V	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	652	EGF-like 4.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						ACAGTTAACTCCTCCCCAGCC	0.498													48	163					3.76525e-18	4.11625e-18	1	0	A	123775763	A	A	123775763	3	1	72	1	0	0	0	0	1	0	0	0	10888	855	30	2	6331	2	ODZ1	23	123775763	Missense_Mutation	SNP	C	TCGA-CN-6013-01A-11D-1683-08	89	123775763	31494797	216	14918											
ZIC3	7547	broad.mit.edu	37	chrX	136652134	136652134	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacccgctatagcttctgcaAacagtaaagataccactaaa	16	8	5	12	1	1	1	0	0	1	1	1	1	1	1	2	0	4	4	2	0	8	6			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chrX:136652134A>C	uc004fak.2	+	3	1814	c.1309A>C	c.(1309-1311)AAC>CAC	p.N437H		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	437					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AGCTTCTGCAAACAGTAAAGA	0.453													31	109					0	0	0	0	C	136652134	C	C	136652134	3	2	72	1	0	0	0	0	1	0	0	0	17747	14	1	5	1319	5	ZIC3	23	136652134	Missense_Mutation	SNP	A	TCGA-CN-6013-01A-11D-1683-08	12876371	136652134	18618426	217	14919											
GAB3	139716	broad.mit.edu	37	chrX	153944337	153944337	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggccaaggttgcagacctGactgatgctgtgcacccaca	9	8	12	12	0	0	3	0	2	0	1	0	3	0	3	3	2	3	4	3	2	1	1			TCGA-CN-6013-01A-11D-1683-08	TCGA-CN-6013-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	992de9b5-c394-48e7-b4e3-4c4aeacb4a23	9496355f-6aa6-4f6a-ac06-b17966b4208c	g.chrX:153944337G>T	uc004fmj.1	-	2	388	c.340C>A	c.(340-342)CAG>AAG	p.Q114K	GAB3_uc004fmk.1_Missense_Mutation_p.Q114K|GAB3_uc010nve.1_Missense_Mutation_p.Q114K|GAB3_uc004fml.1_5'UTR	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	114	PH.									ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTGCAGACCTGACTGATGCTG	0.522													106	50					9.94044e-53	1.1007e-52	1	0	T	153944337	T	T	153944337	3	4	72	1	0	0	0	0	1	0	0	0	6184	1299	45	2	1459	2	GAB3	23	153944337	Missense_Mutation	SNP	G	TCGA-CN-6013-01A-11D-1683-08	17292203	153944337	1326223	218	14920											
CATSPER4	378807	broad.mit.edu	37	chr1	26527434	26527434	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgcgggaggccccctgtcGaacctctcagaaaacacgtg	9	7	11	14	3	1	1	1	0	1	1	3	3	1	2	3	2	3	0	3	2	3	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:26527434G>A	uc010oez.1	+	8	1101	c.1101G>A	c.(1099-1101)TCG>TCA	p.S367S	CATSPER4_uc010oey.1_Silent_p.S189S|CATSPER4_uc009vsf.2_RNA	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	367	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCCCTGTCGAACCTCTCAG	0.542													7	53					0	0	0	0	A	26527434	A	A	26527434	2	1	73	1	0	0	0	0	0	0	0	1	2702	1045	37	1		1	CATSPER4	1	26527434	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08		26527434	222723187	1	14921											
DEPDC1	55635	broad.mit.edu	37	chr1	68947189	68947189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttgactcattcgggaaatCatacgcattaaaagttgaag	14	13	8	6	2	2	2	2	2	0	0	3	3	2	3	0	1	1	2	0	1	5	6			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:68947189C>T	uc001dem.3	-	9	1986	c.1869G>A	c.(1867-1869)ATG>ATA	p.M623I	DEPDC1_uc001dej.3_5'UTR|DEPDC1_uc001dek.3_RNA|DEPDC1_uc001del.3_Missense_Mutation_p.M339I	NM_001114120	NP_001107592	Q5TB30	DEP1A_HUMAN	DEP domain containing 1 isoform a	623	Interaction with ZNF224.				intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		TTCGGGAAATCATACGCATTA	0.393													3	26					0	0	0	0	T	68947189	T	T	68947189	3	4	73	1	0	0	0	0	1	0	0	0	4461	826	29	2	582	2	DEPDC1	1	68947189	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	42419755	68947189	180303432	2	14922											
ZZZ3	26009	broad.mit.edu	37	chr1	78099026	78099026	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcttgtaacacgagtagatCgggaagcagccatactatgg	13	9	11	8	2	1	1	0	0	1	1	2	3	1	2	1	2	4	3	1	2	5	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:78099026C>T	uc001dhq.2	-	5	490	c.14G>A	c.(13-15)CGA>CAA	p.R5Q	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.R5Q|ZZZ3_uc001dhp.2_Missense_Mutation_p.R5Q	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						ACGAGTAGATCGGGAAGCAGC	0.403													9	42					0	0	0	0	T	78099026	T	T	78099026	3	4	73	1	0	0	0	0	1	0	0	0	18323	884	31	1	2741	1	ZZZ3	1	78099026	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	9151837	78099026	171151595	3	14923											
TMED5	50999	broad.mit.edu	37	chr1	93621908	93621908	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtgccagtaatatatttCttccaatcttcttgttcttg	7	20	5	9	0	5	0	0	0	5	0	6	0	6	0	2	0	1	2	2	0	4	9			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:93621908C>A	uc001dpn.2	-	3	867	c.420G>T	c.(418-420)AAG>AAT	p.K140N	TMED5_uc001dpo.2_Missense_Mutation_p.K140N|TMED5_uc001dpp.2_RNA	NM_016040	NP_057124	Q9Y3A6	TMED5_HUMAN	transmembrane emp24 protein transport domain	140	Lumenal (Potential).				transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane				ovary(1)	1		all_lung(203;0.0223)|Lung NSC(277;0.071)|Melanoma(281;0.147)|Glioma(108;0.188)		all cancers(265;0.00108)|GBM - Glioblastoma multiforme(16;0.00407)|Epithelial(280;0.0797)		TAATATATTTCTTCCAATCTT	0.328													12	77					2.27111e-07	2.3861e-07	1	0	A	93621908	A	A	93621908	3	1	73	1	0	0	0	0	1	0	0	0	16073	912	32	2	330	2	TMED5	1	93621908	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	15522882	93621908	155628713	4	14924											
GSTM4	2948	broad.mit.edu	37	chr1	110199342	110199342	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctcttccagctggcccaCgccatccgcctgctcctgga	5	9	8	19	2	1	0	0	0	1	0	5	1	4	1	6	2	2	2	6	2	0	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:110199342C>T	uc001dyf.2	+	2	359	c.45C>T	c.(43-45)CAC>CAT	p.H15H	GSTM4_uc009wfi.2_Silent_p.H15H|GSTM4_uc001dyg.2_Translation_Start_Site|GSTM4_uc009wfj.2_Silent_p.H15H|GSTM4_uc001dyh.2_Silent_p.H15H|GSTM2_uc001dyi.2_Intron	NM_000850	NP_000841	Q03013	GSTM4_HUMAN	glutathione S-transferase mu 4 isoform 1	15	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	AGCTGGCCCACGCCATCCGCC	0.582													23	127					0	0	0	0	T	110199342	T	T	110199342	2	4	73	1	0	0	0	0	0	0	0	1	6879	535	19	1		1	GSTM4	1	110199342	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	16577434	110199342	139051279	5	14925											
CD160	11126	broad.mit.edu	37	chr1	145704173	145704173	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aacaccatctatcccaggatCccttttaagtctcagctgtt	10	13	5	13	0	2	0	1	0	2	0	5	1	4	1	3	1	2	2	3	1	3	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:145704173C>T	uc001eol.1	-	4	462	c.244G>A	c.(244-246)GAT>AAT	p.D82N	NBPF10_uc001emp.3_Intron|CD160_uc001eom.1_Intron|CD160_uc010oyz.1_Intron	NM_007053	NP_008984	O95971	BY55_HUMAN	CD160 antigen precursor	82	Ig-like V-type.				cell proliferation|cell surface receptor linked signaling pathway|cellular defense response|regulation of immune response	anchored to plasma membrane	MHC class I receptor activity|receptor binding				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			ATCCCAGGATCCCTTTTAAGT	0.463													15	90					0	0	0	0	T	145704173	T	T	145704173	3	4	73	1	0	0	0	0	1	0	0	0	2981	855	30	2	313	2	CD160	1	145704173	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	35504831	145704173	103546448	6	14926											
CD160	11126	broad.mit.edu	37	chr1	145704204	145704204	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagctgttttaaactggtCtcaggagaacagtctccaga	11	11	9	10	0	3	2	2	0	2	2	5	3	3	2	1	2	3	2	1	2	3	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:145704204C>G	uc001eol.1	-	4	431	c.213G>C	c.(211-213)GAG>GAC	p.E71D	NBPF10_uc001emp.3_Intron|CD160_uc001eom.1_Intron|CD160_uc010oyz.1_Intron	NM_007053	NP_008984	O95971	BY55_HUMAN	CD160 antigen precursor	71	Ig-like V-type.				cell proliferation|cell surface receptor linked signaling pathway|cellular defense response|regulation of immune response	anchored to plasma membrane	MHC class I receptor activity|receptor binding				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TTAAACTGGTCTCAGGAGAAC	0.438													10	78					0	0	0	0	G	145704204	G	G	145704204	3	3	73	1	0	0	0	0	1	0	0	0	2981	912	32	2	344	2	CD160	1	145704204	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	31	145704204	103546417	7	14927											
MRPL9	65005	broad.mit.edu	37	chr1	151732587	151732587	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctgggctaaccagtacttaTatcttttggtcttgggcttc	6	16	10	9	0	2	0	0	0	2	0	3	0	2	0	1	3	2	4	1	3	4	8			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:151732587T>C	uc001eyv.2	-	7	828	c.743A>G	c.(742-744)TAT>TGT	p.Y248C	MRPL9_uc009wmz.2_RNA	NM_031420	NP_113608	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9 precursor	248					translation	mitochondrial ribosome	structural constituent of ribosome			ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CCAGTACTTATATCTTTTGGT	0.498													6	50					0	0	0	0	C	151732587	C	C	151732587	3	2	73	1	0	0	0	0	1	0	0	0	9873	1406	49	5	64	5	MRPL9	1	151732587	Missense_Mutation	SNP	T	TCGA-CN-6016-01A-11D-1683-08	6028383	151732587	97518034	8	14928											
TDRD10	126668	broad.mit.edu	37	chr1	154492809	154492809	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtaccttctaaaggacttCaaccctcttgatgtccacaa	11	12	5	13	0	3	1	1	1	2	0	4	2	4	2	3	1	2	1	3	1	5	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:154492809C>T	uc009wow.2	+	5	1009	c.171C>T	c.(169-171)TTC>TTT	p.F57F	TDRD10_uc001ffd.2_Silent_p.F57F|TDRD10_uc001ffe.2_5'Flank	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	57	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TAAAGGACTTCAACCCTCTTG	0.423													6	54					0	0	0	0	T	154492809	T	T	154492809	2	4	73	1	0	0	0	0	0	0	0	1	15797	825	29	2		2	TDRD10	1	154492809	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	2760222	154492809	94757812	9	14929											
ADAMTS4	9507	broad.mit.edu	37	chr1	161167904	161167904	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccccaggtcccccagcagAgttaggggtgcctccctcca	7	6	11	17	0	0	1	0	0	0	1	3	1	3	1	7	3	3	2	7	3	1	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:161167904A>G	uc001fyt.3	-	1	942	c.514T>C	c.(514-516)TCT>CCT	p.S172P	ADAMTS4_uc001fyu.2_Missense_Mutation_p.S172P|NDUFS2_uc001fyv.2_5'Flank	NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	172					proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCCCCAGCAGAGTTAGGGGTG	0.637													8	56					0	0	0	0	G	161167904	G	G	161167904	3	3	73	1	0	0	0	0	1	0	0	0	268	304	11	5	2035	5	ADAMTS4	1	161167904	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	6675095	161167904	88082717	10	14930											
PAPPA2	60676	broad.mit.edu	37	chr1	176738784	176738784	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttctgggcactgggaccaGaatgtgagctgccttcccgt	6	11	12	12	1	2	2	0	1	2	1	3	3	3	3	3	2	2	2	3	2	1	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:176738784G>C	uc001gkz.2	+	16	5529	c.4365G>C	c.(4363-4365)CAG>CAC	p.Q1455H	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1455	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ACTGGGACCAGAATGTGAGCT	0.468													16	57					0	0	0	0	C	176738784	C	C	176738784	3	2	73	1	0	0	0	0	1	0	0	0	11487	933	33	2	4476	2	PAPPA2	1	176738784	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	15570880	176738784	72511837	11	14931											
DDX59	83479	broad.mit.edu	37	chr1	200635068	200635068	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctattattaacacttacctcGaataaagctcgcatgataac	15	12	4	10	2	0	1	0	1	0	0	2	2	0	1	1	0	4	2	1	0	8	6			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:200635068G>A	uc009wzk.2	-	2	1044	c.801C>T	c.(799-801)TTC>TTT	p.F267F	DDX59_uc010ppl.1_Silent_p.F267F	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	267	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CACTTACCTCGAATAAAGCTC	0.368													6	46					0	0	0	0	A	200635068	A	A	200635068	2	1	73	1	0	0	0	0	0	0	0	1	4393	1049	37	1		1	DDX59	1	200635068	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08	23896284	200635068	48615553	12	14932											
C1orf186	440712	broad.mit.edu	37	chr1	206243180	206243180	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgagcaggtagttgatggCggtgaggaagcaggcctgca	9	7	18	7	1	0	3	0	3	0	0	0	4	0	4	1	5	3	6	1	5	2	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:206243180C>T	uc001hdt.1	-	3	721	c.82G>A	c.(82-84)GCC>ACC	p.A28T		NM_001007544	NP_001007545	Q6ZWK4	CA186_HUMAN	hypothetical protein LOC440712	28	Helical; (Potential).					integral to membrane					0			BRCA - Breast invasive adenocarcinoma(75;0.0754)			TAGTTGATGGCGGTGAGGAAG	0.517													13	53					0	0	0	0	T	206243180	T	T	206243180	3	4	73	1	0	0	0	0	1	0	0	0	2029	768	27	1	452	1	C1orf186	1	206243180	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	5608112	206243180	43007441	13	14933											
PLXNA2	5362	broad.mit.edu	37	chr1	208205080	208205080	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaacaaggtctcaaacaagtCgtccacaaacttctgcaggg	14	7	9	11	1	2	0	1	0	2	0	5	1	3	0	1	2	4	1	1	2	5	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:208205080C>T	uc001hgz.2	-	29	5838	c.5080G>A	c.(5080-5082)GAC>AAC	p.D1694N	PLXNA2_uc001hgy.2_5'Flank	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1694	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		TCAAACAAGTCGTCCACAAAC	0.577													11	49					0	0	0	0	T	208205080	T	T	208205080	3	4	73	1	0	0	0	0	1	0	0	0	12175	884	31	1	620	1	PLXNA2	1	208205080	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	1961900	208205080	41045541	14	14934											
USH2A	7399	broad.mit.edu	37	chr1	215901489	215901489	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattctggctttgtccaattCaacagaactgaatgagcact	12	12	8	9	0	2	3	1	2	1	1	3	4	3	3	1	1	3	2	1	1	4	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:215901489C>T	uc001hku.1	-	61	12336	c.11949G>A	c.(11947-11949)TTG>TTA	p.L3983L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3983	Fibronectin type-III 25.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTGTCCAATTCAACAGAACTG	0.498										HNSCC(13;0.011)			14	91					0	0	0	0	T	215901489	T	T	215901489	2	4	73	1	0	0	0	0	0	0	0	1	17104	825	29	2		2	USH2A	1	215901489	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	7696409	215901489	33349132	15	14935											
ARID4B	51742	broad.mit.edu	37	chr1	235345577	235345577	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagttgtccgtagagattttCttttttcctccaaaccattg	8	17	6	10	1	1	1	0	0	1	1	4	2	4	1	4	0	1	2	4	0	2	8			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:235345577C>G	uc001hwq.2	-	20	3155	c.2657G>C	c.(2656-2658)AGA>ACA	p.R886T	ARID4B_uc001hwr.2_Missense_Mutation_p.R800T|ARID4B_uc001hws.3_Missense_Mutation_p.R800T|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.R567T	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	886					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TAGAGATTTTCTTTTTTCCTC	0.348													20	92					0	0	0	0	G	235345577	G	G	235345577	3	3	73	1	0	0	0	0	1	0	0	0	920	913	32	2	1301	2	ARID4B	1	235345577	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	19444088	235345577	13905044	16	14936											
HEATR1	55127	broad.mit.edu	37	chr1	236722359	236722359	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggtccagcgctttgcggCgaacagatggcaggggattg	10	7	16	8	3	0	1	0	0	0	1	1	3	1	2	1	5	3	2	1	5	2	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr1:236722359C>T	uc001hyd.1	-	35	4972	c.4847G>A	c.(4846-4848)CGC>CAC	p.R1616H	HEATR1_uc009xgh.1_Missense_Mutation_p.R778H	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1616					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CGCTTTGCGGCGAACAGATGG	0.458													14	55					0	0	0	0	T	236722359	T	T	236722359	3	4	73	1	0	0	0	0	1	0	0	0	7066	768	27	1	1631	1	HEATR1	1	236722359	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	1376782	236722359	12528262	17	14937											
CLIP4	79745	broad.mit.edu	37	chr2	29375604	29375604	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaaaggtcgaaggaagaatAtaacacacactccttctaca	18	7	6	10	1	1	1	0	0	1	1	3	3	2	2	1	2	2	0	1	2	8	4	rs147860020		TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:29375604A>G	uc002rmv.2	+	9	1314	c.1075A>G	c.(1075-1077)ATA>GTA	p.I359V	CLIP4_uc002rmu.2_Missense_Mutation_p.I359V|CLIP4_uc010ezm.1_Missense_Mutation_p.I359V|CLIP4_uc002rmw.2_RNA|CLIP4_uc010ymn.1_Missense_Mutation_p.I341V	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	359										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					AAGGAAGAATATAACACACAC	0.363													4	42					0	0	0	0	G	29375604	G	G	29375604	3	3	73	1	0	0	0	0	1	0	0	0	3550	449	16	5	1105	5	CLIP4	2	29375604	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08		29375604	213823769	18	14938											
DYSF	8291	broad.mit.edu	37	chr2	71828648	71828648	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccggccatccaccatattcCtggttttgaggtaagtcttg	7	13	10	11	1	1	1	0	1	1	0	3	1	3	1	5	3	0	2	5	3	2	6			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:71828648C>T	uc002sie.2	+	35	4239	c.3863C>T	c.(3862-3864)CCT>CTT	p.P1288L	DYSF_uc010feg.2_Missense_Mutation_p.P1319L|DYSF_uc010feh.2_Missense_Mutation_p.P1274L|DYSF_uc002sig.3_Missense_Mutation_p.P1274L|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.P1288L|DYSF_uc010fef.2_Missense_Mutation_p.P1305L|DYSF_uc010fei.2_Missense_Mutation_p.P1305L|DYSF_uc010fek.2_Missense_Mutation_p.P1306L|DYSF_uc010fej.2_Missense_Mutation_p.P1275L|DYSF_uc010fel.2_Missense_Mutation_p.P1275L|DYSF_uc010feo.2_Missense_Mutation_p.P1320L|DYSF_uc010fem.2_Missense_Mutation_p.P1289L|DYSF_uc010fen.2_Missense_Mutation_p.P1306L|DYSF_uc002sif.2_Missense_Mutation_p.P1289L|DYSF_uc010yqy.1_Missense_Mutation_p.P169L|DYSF_uc010yqz.1_Missense_Mutation_p.P28L	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1288	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CACCATATTCCTGGTTTTGAG	0.512													7	47					0	0	0	0	T	71828648	T	T	71828648	3	4	73	1	0	0	0	0	1	0	0	0	4881	681	24	4	4193	4	DYSF	2	71828648	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	42453044	71828648	171370725	19	14939											
NCAPH	23397	broad.mit.edu	37	chr2	97007517	97007517	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcctggcaccccagtcctcGaagactttcctcagaatgac	9	10	7	15	1	1	3	1	1	0	2	5	4	4	3	5	1	0	1	5	1	2	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:97007517G>A	uc002svz.1	+	2	241	c.157G>A	c.(157-159)GAA>AAA	p.E53K	NCAPH_uc010fhu.1_Missense_Mutation_p.E29K|NCAPH_uc010fhv.1_Missense_Mutation_p.E42K|NCAPH_uc010yum.1_Missense_Mutation_p.E29K|NCAPH_uc010fhw.1_Missense_Mutation_p.E42K|NCAPH_uc010yun.1_Intron|NCAPH_uc002swa.1_Intron	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	53					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				CCCAGTCCTCGAAGACTTTCC	0.597													18	91					0	0	0	0	A	97007517	A	A	97007517	3	1	73	1	0	0	0	0	1	0	0	0	10263	1059	37	1	163	1	NCAPH	2	97007517	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	25178869	97007517	146191856	20	14940											
EPB41L5	57669	broad.mit.edu	37	chr2	120833323	120833323	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcaattggcagcttataatCtgcaaggtaagcaattctta	13	13	8	7	0	2	0	0	0	2	0	2	0	2	0	0	2	4	6	0	2	7	6			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:120833323C>G	uc002tmg.2	+	7	625	c.499C>G	c.(499-501)CTG>GTG	p.L167V	EPB41L5_uc010flk.2_Missense_Mutation_p.L167V|EPB41L5_uc010fll.2_Missense_Mutation_p.L167V|EPB41L5_uc002tmh.3_Missense_Mutation_p.L167V|EPB41L5_uc010flm.2_5'Flank	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	167	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1						AGCTTATAATCTGCAAGGTAA	0.323													10	56					0	0	0	0	G	120833323	G	G	120833323	3	3	73	1	0	0	0	0	1	0	0	0	5181	912	32	2	521	2	EPB41L5	2	120833323	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	23825806	120833323	122366050	21	14941											
POTEF	728378	broad.mit.edu	37	chr2	130832564	130832564	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtacatggctggggtgttGaaggtctcaaacatgatctg	10	11	13	7	1	2	2	1	2	2	0	3	2	2	2	0	4	2	3	0	4	3	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:130832564G>A	uc010fmh.2	-	17	2881	c.2481C>T	c.(2479-2481)TTC>TTT	p.F827F		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	827	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						CTGGGGTGTTGAAGGTCTCAA	0.612													32	118					0	0	0	0	A	130832564	A	A	130832564	2	1	73	1	0	0	0	0	0	0	0	1	12320	1281	45	2		2	POTEF	2	130832564	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08	9999241	130832564	112366809	22	14942											
NEB	4703	broad.mit.edu	37	chr2	152483523	152483523	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgggggctcaccttgttcAtattgagagcattgttcttg	7	16	11	7	0	3	1	2	1	1	1	3	2	3	1	1	2	1	4	1	2	1	8			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:152483523A>G	uc010fnx.2	-	66	9802	c.9611T>C	c.(9610-9612)ATG>ACG	p.M3204T		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3204	Nebulin 87.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CACCTTGTTCATATTGAGAGC	0.408													16	61					0	0	0	0	G	152483523	G	G	152483523	3	3	73	1	0	0	0	0	1	0	0	0	10356	217	8	5	15798	5	NEB	2	152483523	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	21650959	152483523	90715850	23	14943											
HNRNPA3	220988	broad.mit.edu	37	chr2	178080540	178080540	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtgacttattcttgtgtTgaagaggtggatgcagcaat	9	16	12	4	0	1	3	0	2	1	1	1	4	1	4	0	2	2	3	0	2	3	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:178080540T>C	uc002ulb.1	+	3	364	c.258T>C	c.(256-258)GTT>GTC	p.V86V	HNRNPA3_uc002ulc.1_Silent_p.V86V|HNRNPA3_uc002uld.2_Silent_p.V64V|HNRNPA3_uc002ule.2_5'Flank	NM_194247	NP_919223	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	86	RRM 1.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(2)	2						ATTCTTGTGTTGAAGAGGTGG	0.408													17	95					0	0	0	0	C	178080540	C	C	178080540	2	2	73	1	0	0	0	0	0	0	0	1	7299	1799	63	5		5	HNRNPA3	2	178080540	Silent	SNP	T	TCGA-CN-6016-01A-11D-1683-08	25597017	178080540	65118833	24	14944											
OSBPL6	114880	broad.mit.edu	37	chr2	179251794	179251794	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctatgtcatttagatatcaGatggaaaaacaagttctggg	14	12	9	6	0	3	2	2	0	1	2	3	3	3	3	1	2	1	1	1	2	6	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:179251794G>A	uc002ulx.2	+	20	2462	c.2084G>A	c.(2083-2085)AGA>AAA	p.R695K	OSBPL6_uc002uly.2_Missense_Mutation_p.R720K|OSBPL6_uc010zfe.1_Missense_Mutation_p.R664K|OSBPL6_uc002ulz.2_Missense_Mutation_p.R659K|OSBPL6_uc002uma.2_Missense_Mutation_p.R699K	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	695					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			TTAGATATCAGATGGAAAAAC	0.398													5	28					0	0	0	0	A	179251794	A	A	179251794	3	1	73	1	0	0	0	0	1	0	0	0	11335	942	33	2	2276	2	OSBPL6	2	179251794	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	1171254	179251794	63947579	25	14945											
TTN	7273	broad.mit.edu	37	chr2	179641976	179641976	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgactttcatttcaagtcGggaaccttcctttatattga	9	17	6	9	1	3	2	2	2	1	0	5	3	4	3	2	1	1	0	2	1	4	7			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:179641976G>A	uc010zfg.1	-	27	4938	c.4714C>T	c.(4714-4716)CGA>TGA	p.R1572*	TTN_uc010zfh.1_Nonsense_Mutation_p.R1526*|TTN_uc010zfi.1_Nonsense_Mutation_p.R1526*|TTN_uc010zfj.1_Nonsense_Mutation_p.R1526*|TTN_uc002unb.2_Nonsense_Mutation_p.R1572*|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1572							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTCAAGTCGGGAACCTTCC	0.393													21	70					0	0	0	0	A	179641976	A	A	179641976	4	1	73	1	0	0	0	0	0	1	0	0	16803	1124	39	1	106618	1	TTN	2	179641976	Nonsense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	390182	179641976	63557397	26	14946											
ORC2L	4999	broad.mit.edu	37	chr2	201791527	201791527	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggaaagaagccattgatGacaacgtgaatggaatcttg	15	8	11	7	1	1	4	0	3	1	1	1	6	1	6	2	2	2	0	2	2	5	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:201791527G>T	uc002uwr.2	-	12	1271	c.1014C>A	c.(1012-1014)GTC>GTA	p.V338V	ORC2L_uc010zhj.1_Silent_p.V338V	NM_006190	NP_006181	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2	338					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0						AGCCATTGATGACAACGTGAA	0.388													9	75					0.00621372	0.00632808	1	0	T	201791527	T	T	201791527	2	4	73	1	0	0	0	0	0	0	0	1	11316	1277	45	2		2	ORC2L	2	201791527	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08	22149551	201791527	41407846	27	14947											
GIGYF2	26058	broad.mit.edu	37	chr2	233684583	233684583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaagaaattgcattaaggcGacagcgagaagaggaagaaa	19	4	13	5	2	0	4	0	0	0	4	0	7	0	5	0	2	2	2	0	2	6	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr2:233684583G>A	uc002vti.3	+	23	2754	c.2417G>A	c.(2416-2418)CGA>CAA	p.R806Q	GIGYF2_uc002vtg.2_Missense_Mutation_p.R800Q|GIGYF2_uc002vtj.3_Missense_Mutation_p.R827Q|GIGYF2_uc002vtk.3_Missense_Mutation_p.R806Q|GIGYF2_uc002vth.3_Missense_Mutation_p.R800Q|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.R637Q|GIGYF2_uc002vtq.3_Missense_Mutation_p.R139Q	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	806	Gln-rich.|Glu-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GCATTAAGGCGACAGCGAGAA	0.512													5	22					0	0	0	0	A	233684583	A	A	233684583	3	1	73	1	0	0	0	0	1	0	0	0	6415	1058	37	1	2561	1	GIGYF2	2	233684583	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	31893056	233684583	9514790	28	14948											
IL17RC	84818	broad.mit.edu	37	chr3	9960234	9960234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggcctaccctactgccCgctgcgtcctgctggaggtg	4	9	12	16	2	0	0	0	0	0	0	2	1	2	1	5	3	5	2	5	3	2	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr3:9960234C>T	uc003bua.2	+	5	855	c.619C>T	c.(619-621)CGC>TGC	p.R207C	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_RNA|IL17RC_uc011ato.1_RNA|IL17RC_uc010hcs.2_Missense_Mutation_p.R111C|IL17RC_uc003btz.2_Missense_Mutation_p.R136C|IL17RC_uc011atp.1_Missense_Mutation_p.R7C|IL17RC_uc003bud.2_5'UTR|IL17RC_uc003bub.2_Missense_Mutation_p.R136C|IL17RC_uc010hct.2_Missense_Mutation_p.R136C|IL17RC_uc010hcu.2_Missense_Mutation_p.R136C|IL17RC_uc010hcv.2_Missense_Mutation_p.R136C|IL17RC_uc011atq.1_Missense_Mutation_p.R136C|IL17RC_uc003buc.2_5'UTR	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	207	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						CCCTACTGCCCGCTGCGTCCT	0.572													8	51					0	0	0	0	T	9960234	T	T	9960234	3	4	73	1	0	0	0	0	1	0	0	0	7680	652	23	1	637	1	IL17RC	3	9960234	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08		9960234	188062196	29	14949											
C3orf10	55845	broad.mit.edu	37	chr3	10157479	10157479	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaccagcagcatcaagaaaAtcgcagactttctcaactcg	14	8	6	13	2	3	2	3	0	1	2	6	2	3	2	1	0	3	3	1	0	4	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr3:10157479A>G	uc003bvb.2	+	1	147	c.94A>G	c.(94-96)ATC>GTC	p.I32V		NM_018462	NP_060932	Q8WUW1	BRK1_HUMAN	chromosome 3 open reading frame 10	32						cytoplasm|cytoskeleton					0						CATCAAGAAAATCGCAGACTT	0.632													7	30					0	0	0	0	G	10157479	G	G	10157479	3	3	73	1	0	0	0	0	1	0	0	0	2217	101	4	5	96	5	C3orf10	3	10157479	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	197245	10157479	187864951	30	14950											
RARB	5915	broad.mit.edu	37	chr3	25611301	25611301	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagacttcgaagcaagaatgCacagagagctatgaaatgac	17	6	11	7	1	0	5	0	2	0	3	1	8	0	5	0	0	3	3	0	0	5	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr3:25611301C>T	uc011awl.1	+	4	588	c.522C>T	c.(520-522)TGC>TGT	p.C174C	RARB_uc003cdi.1_Silent_p.C55C|RARB_uc003cdh.2_Silent_p.C167C	NM_016152	NP_057236	P10826	RARB_HUMAN	retinoic acid receptor, beta isoform 2	174	Hinge.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	AGCAAGAATGCACAGAGAGCT	0.493													5	43					0	0	0	0	T	25611301	T	T	25611301	2	4	73	1	0	0	0	0	0	0	0	1	13118	718	25	4		4	RARB	3	25611301	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	15453822	25611301	172411129	31	14951											
TRAK1	22906	broad.mit.edu	37	chr3	42242386	42242386	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatctctgaccccttctcccAtgaacatccccggctccaac	8	9	5	19	1	2	2	0	2	2	0	6	3	4	2	6	1	2	1	6	1	2	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr3:42242386A>G	uc003cky.2	+	12	1483	c.1267A>G	c.(1267-1269)ATG>GTG	p.M423V	TRAK1_uc011azh.1_Missense_Mutation_p.M423V|TRAK1_uc011azi.1_Missense_Mutation_p.M423V|TRAK1_uc003ckz.3_Missense_Mutation_p.M349V|TRAK1_uc011azj.1_Missense_Mutation_p.M349V|TRAK1_uc003cla.2_Missense_Mutation_p.M365V	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	423	Interaction with HGS.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						CCCTTCTCCCATGAACATCCC	0.567													13	67					0	0	0	0	G	42242386	G	G	42242386	3	3	73	1	0	0	0	0	1	0	0	0	16516	217	8	5	1429	5	TRAK1	3	42242386	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	16631085	42242386	155780044	32	14952											
KIF15	56992	broad.mit.edu	37	chr3	44852484	44852484	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgagccagttcctcctgaGatgaatgaacaagcttttga	13	11	9	8	0	0	5	0	5	0	1	2	6	2	5	3	0	3	2	3	0	4	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr3:44852484G>A	uc003cnx.3	+	17	2267	c.2118G>A	c.(2116-2118)GAG>GAA	p.E706E	KIF15_uc010hiq.2_Silent_p.E609E|KIF15_uc003cny.1_Silent_p.E341E	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	706	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		TTCCTCCTGAGATGAATGAAC	0.343													9	50					0	0	0	0	A	44852484	A	A	44852484	2	1	73	1	0	0	0	0	0	0	0	1	8316	933	33	2		2	KIF15	3	44852484	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08	2610098	44852484	153169946	33	14953											
SLC12A8	84561	broad.mit.edu	37	chr3	124810400	124810400	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gatgagaagggacccaacagCctgtgaaaacagagtaggaa	17	4	13	7	0	0	3	0	2	0	2	0	7	0	5	2	2	3	1	2	2	6	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr3:124810400C>A	uc003ehv.3	-	12	1915	c.1804G>T	c.(1804-1806)GCT>TCT	p.A602S	SLC12A8_uc003ehw.3_Missense_Mutation_p.A631S|SLC12A8_uc003eht.3_Missense_Mutation_p.A403S|SLC12A8_uc003ehu.3_Missense_Mutation_p.A355S|SLC12A8_uc010hry.2_Intron	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	602	Helical; (Potential).				potassium ion transport	integral to membrane	symporter activity				0						GACCCAACAGCCTGTGAAAAC	0.468													10	26					0.00621372	0.00632808	1	0	A	124810400	A	A	124810400	3	1	73	1	0	0	0	0	1	0	0	0	14454	753	26	4	352	4	SLC12A8	3	124810400	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	79957916	124810400	73212030	34	14954											
VEPH1	79674	broad.mit.edu	37	chr3	157031448	157031448	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggactccatcatggcagtttCaaagctgtgagcaccccctg	9	9	10	13	0	2	1	2	1	0	0	3	2	3	2	3	2	2	4	3	2	1	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr3:157031448C>G	uc003fbj.1	-	11	2289	c.1972G>C	c.(1972-1974)GAA>CAA	p.E658Q	VEPH1_uc003fbk.1_Missense_Mutation_p.E658Q|VEPH1_uc010hvu.1_Intron	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	658						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			ATGGCAGTTTCAAAGCTGTGA	0.478													12	46					0	0	0	0	G	157031448	G	G	157031448	3	3	73	1	0	0	0	0	1	0	0	0	17222	835	29	2	545	2	VEPH1	3	157031448	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	32221048	157031448	40990982	35	14955											
SI	6476	broad.mit.edu	37	chr3	164764678	164764678	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcattccagttatagaccatTccatttgttcccatgaagca	11	13	6	11	0	0	2	0	1	0	1	3	2	3	2	4	0	1	4	4	0	3	6			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr3:164764678T>A	uc003fei.2	-	16	1900	c.1838A>T	c.(1837-1839)GAA>GTA	p.E613V		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	613	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TATAGACCATTCCATTTGTTC	0.383										HNSCC(35;0.089)			29	91					0	0	0	0	A	164764678	A	A	164764678	3	1	73	1	0	0	0	0	1	0	0	0	14362	1783	62	5	3777	5	SI	3	164764678	Missense_Mutation	SNP	T	TCGA-CN-6016-01A-11D-1683-08	7733230	164764678	33257752	36	14956											
KLHL24	54800	broad.mit.edu	37	chr3	183368442	183368442	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgttttgtaatgaccacAgggaaagccgagaaatgttg	13	11	11	6	1	0	2	0	1	0	1	0	4	0	3	2	1	1	3	2	1	4	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr3:183368442A>G	uc003flv.2	+	3	593	c.298A>G	c.(298-300)AGG>GGG	p.R100G	KLHL24_uc003flw.2_Missense_Mutation_p.R100G|KLHL24_uc003flx.2_Missense_Mutation_p.R100G	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	100	BTB.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			TAATGACCACAGGGAAAGCCG	0.398													52	119					0	0	0	0	G	183368442	G	G	183368442	3	3	73	1	0	0	0	0	1	0	0	0	8418	179	7	5	300	5	KLHL24	3	183368442	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	18603764	183368442	14653988	37	14957											
RTP1	132112	broad.mit.edu	37	chr3	186917476	186917476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtgctatgagtgcggcaCggcgcggctggacgagtcca	6	7	17	11	5	0	1	0	1	0	0	1	3	1	2	1	4	2	4	1	4	1	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr3:186917476C>T	uc003frg.2	+	2	440	c.410C>T	c.(409-411)ACG>ATG	p.T137M		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	137	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		GAGTGCGGCACGGCGCGGCTG	0.662													8	40					0	0	0	0	T	186917476	T	T	186917476	3	4	73	1	0	0	0	0	1	0	0	0	13798	536	19	1	416	1	RTP1	3	186917476	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	3549034	186917476	11104954	38	14958											
KLB	152831	broad.mit.edu	37	chr4	39449964	39449964	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaaaggctattatgcattCaaactggctgaagagaaatc	16	10	8	7	0	2	2	2	1	0	1	3	3	2	2	0	2	2	3	0	2	6	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr4:39449964C>G	uc003gua.2	+	5	2890	c.2793C>G	c.(2791-2793)TTC>TTG	p.F931L	KLB_uc011byj.1_Missense_Mutation_p.F922L	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	931	Extracellular (Potential).|Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						ATTATGCATTCAAACTGGCTG	0.323													7	34					0	0	0	0	G	39449964	G	G	39449964	3	3	73	1	0	0	0	0	1	0	0	0	8371	825	29	2	2811	2	KLB	4	39449964	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08		39449964	151704312	39	14959											
SLC4A4	8671	broad.mit.edu	37	chr4	72316995	72316995	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggaggacatggggattgTgaagaattgcagcgaactgg	12	7	18	4	1	0	2	0	1	0	1	0	7	0	6	0	6	3	1	0	6	3	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr4:72316995T>C	uc003hfy.2	+	11	1416	c.1299T>C	c.(1297-1299)TGT>TGC	p.C433C	SLC4A4_uc010iic.2_Silent_p.C433C|SLC4A4_uc010iib.2_Silent_p.C433C|SLC4A4_uc003hfz.2_Silent_p.C433C|SLC4A4_uc003hgc.3_Silent_p.C389C|SLC4A4_uc010iid.2_5'UTR|SLC4A4_uc003hga.2_Silent_p.C311C|SLC4A4_uc003hgb.3_Silent_p.C389C	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	433	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			ATGGGGATTGTGAAGAATTGC	0.433													8	39					0	0	0	0	C	72316995	C	C	72316995	2	2	73	1	0	0	0	0	0	0	0	1	14720	1702	59	5		5	SLC4A4	4	72316995	Silent	SNP	T	TCGA-CN-6016-01A-11D-1683-08	32867031	72316995	118837281	40	14960											
FAM13A	10144	broad.mit.edu	37	chr4	89660214	89660214	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgttagctcgggagaggatCtgtttgaccagccggtacct	7	11	14	9	2	1	2	0	1	1	1	2	4	1	3	3	3	3	4	3	3	2	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr4:89660214C>G	uc003hse.1	-	20	2737	c.2529G>C	c.(2527-2529)CAG>CAC	p.Q843H	FAM13A_uc011cdp.1_5'Flank|FAM13A_uc003hsa.1_Missense_Mutation_p.Q314H|FAM13A_uc003hsb.1_Missense_Mutation_p.Q517H|FAM13A_uc003hsd.1_Missense_Mutation_p.Q517H|FAM13A_uc003hsc.1_Missense_Mutation_p.Q503H|FAM13A_uc011cdq.1_Missense_Mutation_p.Q489H|FAM13A_uc003hsf.1_Missense_Mutation_p.Q429H|FAM13A_uc003hsg.1_Missense_Mutation_p.Q314H	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	843					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						GGGAGAGGATCTGTTTGACCA	0.493													8	32					0	0	0	0	G	89660214	G	G	89660214	3	3	73	1	0	0	0	0	1	0	0	0	5480	912	32	2	562	2	FAM13A	4	89660214	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	17343219	89660214	101494062	41	14961											
UNC5C	8633	broad.mit.edu	37	chr4	96256763	96256763	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaggaaaagtttctgggagTtcatgaaaaaagtcatcatc	16	10	10	5	0	4	1	3	1	1	0	5	4	4	3	0	2	0	2	0	2	6	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr4:96256763T>C	uc003htp.1	-	2	298	c.144A>G	c.(142-144)GAA>GAG	p.E48E	UNC5C_uc010ilc.1_Silent_p.E48E|UNC5C_uc003htq.2_Silent_p.E48E	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	48	Extracellular (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TTTCTGGGAGTTCATGAAAAA	0.393													5	24					0	0	0	0	C	96256763	C	C	96256763	2	2	73	1	0	0	0	0	0	0	0	1	17061	1722	60	5		5	UNC5C	4	96256763	Silent	SNP	T	TCGA-CN-6016-01A-11D-1683-08	6596549	96256763	94897513	42	14962											
PRDM5	11107	broad.mit.edu	37	chr4	121732584	121732584	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttattgcacactgaacataTaagctttttcttaggatctc	11	17	5	8	0	2	1	0	1	2	0	3	2	2	2	0	1	3	2	0	1	5	8			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr4:121732584T>C	uc003idn.2	-	8	1136	c.886A>G	c.(886-888)ATA>GTA	p.I296V	PRDM5_uc003ido.2_Missense_Mutation_p.I265V|PRDM5_uc010ine.2_Missense_Mutation_p.I265V	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	296	C2H2-type 5.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						ACTGAACATATAAGCTTTTTC	0.299													4	27					0	0	0	0	C	121732584	C	C	121732584	3	2	73	1	0	0	0	0	1	0	0	0	12522	1406	49	5	1042	5	PRDM5	4	121732584	Missense_Mutation	SNP	T	TCGA-CN-6016-01A-11D-1683-08	25475821	121732584	69421692	43	14963											
PCDH18	54510	broad.mit.edu	37	chr4	138450946	138450946	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atctgatgggcagagtgccaTttatggtaggcaccaatgtg	10	11	13	7	0	1	2	0	1	1	1	1	2	1	2	2	3	1	3	2	3	3	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr4:138450946T>C	uc003ihe.3	-	1	2684	c.2297A>G	c.(2296-2298)AAT>AGT	p.N766S	PCDH18_uc003ihf.3_Missense_Mutation_p.N759S|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.N546S|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	766	Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					CAGAGTGCCATTTATGGTAGG	0.517													11	55					0	0	0	0	C	138450946	C	C	138450946	3	2	73	1	0	0	0	0	1	0	0	0	11567	1493	52	5	1126	5	PCDH18	4	138450946	Missense_Mutation	SNP	T	TCGA-CN-6016-01A-11D-1683-08	16718362	138450946	52703330	44	14964											
FAT1	2195	broad.mit.edu	37	chr4	187557335	187557336	+	Frame_Shift_Ins	INS	-	A	A																															ggcttggagatccattcaatINSatggagtctggtggttgatg																										TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr4:187557335_187557336insA	uc003izf.2	-	6	4214_4215	c.4026_4027insT	c.(4024-4029)CATATTfs	p.H1342fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1342_1343	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATCCATTCAATATGGAGTCTGG	0.436										HNSCC(5;0.00058)			---	---	---								A	187557336	A	A	187557335	7	5	73	1	0	1	1	0	0	0	0	0	5721	1406	49	0	9827	0	FAT1	4	187557335	Frame_Shift_Ins	INS	-	TCGA-CN-6016-01A-11D-1683-08	49106389	187557335	3596941	45	14965											
NPR3	4883	broad.mit.edu	37	chr5	32712139	32712139	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgcgcagcgtggagggcaAcgggactgggaggcggcttc	6	6	19	10	4	1	0	0	0	1	0	2	3	1	3	0	6	3	3	0	6	1	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr5:32712139A>G	uc003jhv.2	+	1	475	c.257A>G	c.(256-258)AAC>AGC	p.N86S	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Missense_Mutation_p.N86S	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	86	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GTGGAGGGCAACGGGACTGGG	0.632													4	46					0	0	0	0	G	32712139	G	G	32712139	3	3	73	1	0	0	0	0	1	0	0	0	10650	43	2	5	259	5	NPR3	5	32712139	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08		32712139	148203121	46	14966											
GZMK	3003	broad.mit.edu	37	chr5	54329703	54329703	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctacaccctgttaaccaaGaaataccagacttggatcaa	16	9	5	11	0	2	2	1	0	1	2	2	3	2	3	3	1	3	1	3	1	6	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr5:54329703G>C	uc003jpl.1	+	5	788	c.744G>C	c.(742-744)AAG>AAC	p.K248N		NM_002104	NP_002095	P49863	GRAK_HUMAN	granzyme K precursor	248	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				TGTTAACCAAGAAATACCAGA	0.423													6	58					0	0	0	0	C	54329703	C	C	54329703	3	2	73	1	0	0	0	0	1	0	0	0	6957	933	33	2	762	2	GZMK	5	54329703	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	21617564	54329703	126585557	47	14967											
PCDHB1	29930	broad.mit.edu	37	chr5	140431659	140431659	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgaacaaacccctggacCgagaggagcagcctgaagtc	12	5	12	12	1	0	3	0	2	0	1	1	6	0	5	4	2	5	2	4	2	3	0			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr5:140431659C>T	uc003lik.1	+	1	681	c.604C>T	c.(604-606)CGA>TGA	p.R202*		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	202	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCCCTGGACCGAGAGGAGCA	0.577													4	27					0	0	0	0	T	140431659	T	T	140431659	4	4	73	1	0	0	0	0	0	1	0	0	11588	644	23	1	606	1	PCDHB1	5	140431659	Nonsense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	86101956	140431659	40483601	48	14968											
TLX3	30012	broad.mit.edu	37	chr5	170738466	170738466	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcagctgcaacacgacGccttccaaaagagcctcaac	12	6	8	15	2	1	1	1	0	0	1	2	2	2	1	3	0	7	4	3	0	4	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr5:170738466G>A	uc003mbf.2	+	3	821	c.739G>A	c.(739-741)GCC>ACC	p.A247T	uc003mbe.1_5'Flank	NM_021025	NP_066305	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	247						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCAACACGACGCCTTCCAAAA	0.652			T	BCL11B	T-ALL								5	14					0	0	0	0	A	170738466	A	A	170738466	3	1	73	1	0	0	0	0	1	0	0	0	16028	1087	38	1	749	1	TLX3	5	170738466	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	30306807	170738466	10176794	49	14969											
TDP2	51567	broad.mit.edu	37	chr6	24658077	24658077	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttacttgatctcttctttagGtagctataatatgggggaat	10	17	9	5	0	2	1	0	1	2	0	3	2	2	2	0	3	2	2	0	3	7	9			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr6:24658077G>A	uc003nej.2	-	4	505	c.480C>T	c.(478-480)TAC>TAT	p.Y160Y	TDP2_uc003nei.2_Silent_p.Y48Y|TDP2_uc010jpu.1_Silent_p.Y160Y	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	160					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2						TCTTCTTTAGGTAGCTATAAT	0.299								Direct_reversal_of_damage|Editing_and_processing_nucleases					10	51					0	0	0	0	A	24658077	A	A	24658077	2	1	73	1	0	0	0	0	0	0	0	1	15795	1256	44	4		4	TDP2	6	24658077	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08		24658077	146456990	50	14970											
DHX16	8449	broad.mit.edu	37	chr6	30624814	30624814	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaccctggatccagcacaTaaatgatgccctcaatggtg	13	8	9	11	0	1	2	1	1	0	1	2	3	2	3	3	2	3	1	3	2	4	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr6:30624814T>A	uc003nqz.2	-	13	2275	c.2063A>T	c.(2062-2064)TAT>TTT	p.Y688F	DHX16_uc003nqy.2_Missense_Mutation_p.Y207F|DHX16_uc011dmo.1_Missense_Mutation_p.Y628F	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	688	Helicase C-terminal.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						ATCCAGCACATAAATGATGCC	0.542													5	24					0	0	0	0	A	30624814	A	A	30624814	3	1	73	1	0	0	0	0	1	0	0	0	4524	1406	49	5	1094	5	DHX16	6	30624814	Missense_Mutation	SNP	T	TCGA-CN-6016-01A-11D-1683-08	5966737	30624814	140490253	51	14971											
ITPR3	3710	broad.mit.edu	37	chr6	33636358	33636358	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccccgtcacccaagagctCatctgcaagtgtgtgctgga	9	9	10	13	1	3	1	2	0	1	1	4	2	4	2	3	1	3	3	3	1	2	0			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr6:33636358C>G	uc011drk.1	+	17	2172	c.1953C>G	c.(1951-1953)CTC>CTG	p.L651L		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	651	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CCCAAGAGCTCATCTGCAAGT	0.617													12	37					0	0	0	0	G	33636358	G	G	33636358	2	3	73	1	0	0	0	0	0	0	0	1	7961	813	29	2		2	ITPR3	6	33636358	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	3011544	33636358	137478709	52	14972											
TRERF1	55809	broad.mit.edu	37	chr6	42222641	42222641	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaacctgacaggcttccgCagtagcagcatttccagagc	10	10	9	12	1	0	2	0	1	0	1	2	2	2	2	3	1	4	5	3	1	2	5	rs143046982		TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr6:42222641C>T	uc003osd.2	-	13	3167	c.2604G>A	c.(2602-2604)CTG>CTA	p.L868L	TRERF1_uc011duq.1_Silent_p.L785L|TRERF1_uc003osb.2_Silent_p.L624L|TRERF1_uc003osc.2_Silent_p.L624L|TRERF1_uc003ose.2_Silent_p.L888L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	868	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CAGGCTTCCGCAGTAGCAGCA	0.522													12	31					0	0	0	0	T	42222641	T	T	42222641	2	4	73	1	0	0	0	0	0	0	0	1	16542	697	25	4		4	TRERF1	6	42222641	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	8586283	42222641	128892426	53	14973											
KLHDC3	116138	broad.mit.edu	37	chr6	42986153	42986153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgtatgtctttgggggcCgtgccgaccgctttgggcca	5	11	14	11	3	1	0	0	0	1	0	1	1	1	0	4	3	1	2	4	3	1	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr6:42986153C>T	uc003otl.2	+	6	761	c.592C>T	c.(592-594)CGT>TGT	p.R198C	KLHDC3_uc003otm.2_RNA|KLHDC3_uc010jyf.2_Missense_Mutation_p.R174C|KLHDC3_uc003otn.2_Missense_Mutation_p.R82C|KLHDC3_uc003oto.2_Missense_Mutation_p.R139C	NM_057161	NP_476502	Q9BQ90	KLDC3_HUMAN	kelch domain containing 3	198	Kelch 4.				reciprocal meiotic recombination	cytoplasm|nuclear chromatin	chromatin binding|protein binding			upper_aerodigestive_tract(1)	1			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CTTTGGGGGCCGTGCCGACCG	0.577													26	41					0	0	0	0	T	42986153	T	T	42986153	3	4	73	1	0	0	0	0	1	0	0	0	8396	652	23	1	610	1	KLHDC3	6	42986153	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	763512	42986153	128128914	54	14974											
MCM3	4172	broad.mit.edu	37	chr6	52141938	52141938	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggccagtggtggggatagcTcggggtgcagtgcaaagcac	8	6	18	9	2	0	0	0	0	0	0	1	1	0	1	1	6	4	4	1	6	2	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr6:52141938T>A	uc003pan.1	-	8	1202	c.1092A>T	c.(1090-1092)CGA>CGT	p.R364R	MCM3_uc011dwu.1_Silent_p.R318R	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	364	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					TGGGGATAGCTCGGGGTGCAG	0.592													12	50					0	0	0	0	A	52141938	A	A	52141938	2	1	73	1	0	0	0	0	0	0	0	1	9440	1538	54	5		5	MCM3	6	52141938	Silent	SNP	T	TCGA-CN-6016-01A-11D-1683-08	9155785	52141938	118973129	55	14975											
COL19A1	1310	broad.mit.edu	37	chr6	70639472	70639472	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attagtatacaatcccaggtCatttcactttatatggattg	12	16	6	7	0	2	0	2	0	0	0	3	1	3	1	1	2	1	1	1	2	6	8			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr6:70639472C>T	uc003pfc.1	+	6	663	c.546C>T	c.(544-546)GTC>GTT	p.V182V	COL19A1_uc010kam.1_Silent_p.V78V	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	182	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						AATCCCAGGTCATTTCACTTT	0.418													11	68					0	0	0	0	T	70639472	T	T	70639472	2	4	73	1	0	0	0	0	0	0	0	1	3691	813	29	2		2	COL19A1	6	70639472	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	18497534	70639472	100475595	56	14976											
FAM184A	79632	broad.mit.edu	37	chr6	119295660	119295660	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attaaaatctgcccgcatgaTatttttctctctgaggtggt	9	16	8	8	1	3	2	0	2	3	0	4	2	3	2	1	2	1	1	1	2	3	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr6:119295660T>C	uc003pyj.2	-	14	3196	c.2848A>G	c.(2848-2850)ATC>GTC	p.I950V	FAM184A_uc003pyk.3_Intron|FAM184A_uc003pyl.3_Intron|FAM184A_uc003pyi.2_RNA	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	950										ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						GCCCGCATGATATTTTTCTCT	0.338													58	177					0	0	0	0	C	119295660	C	C	119295660	3	2	73	1	0	0	0	0	1	0	0	0	5539	1406	49	5	594	5	FAM184A	6	119295660	Missense_Mutation	SNP	T	TCGA-CN-6016-01A-11D-1683-08	48656188	119295660	51819407	57	14977											
CNKSR3	154043	broad.mit.edu	37	chr6	154831199	154831199	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccccaaggcccgcgcacctCtagtccagtccaccacttgt	7	7	7	20	2	1	0	0	0	1	0	3	0	3	0	7	1	0	1	7	1	2	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr6:154831199C>G	uc003qpy.2	-	1	555	c.50G>C	c.(49-51)AGA>ACA	p.R17T		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	17	SAM.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		CCGCGCACCTCTAGTCCAGTC	0.647													21	126					0	0	0	0	G	154831199	G	G	154831199	3	3	73	1	0	0	0	0	1	0	0	0	3623	913	32	2	1669	2	CNKSR3	6	154831199	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	35535539	154831199	16283868	58	14978											
RPS6KA2	6196	broad.mit.edu	37	chr6	166944753	166944753	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttaaggaccttcatggCgtagagctgcccagcgtcgg	7	11	12	11	3	2	1	1	0	1	1	3	2	2	2	2	3	3	2	2	3	2	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr6:166944753C>T	uc003qvb.1	-	3	484	c.265G>A	c.(265-267)GCC>ACC	p.A89T	RPS6KA2_uc011ego.1_5'UTR|RPS6KA2_uc010kkl.1_5'UTR|RPS6KA2_uc003qvc.1_Missense_Mutation_p.A97T|RPS6KA2_uc003qvd.1_Missense_Mutation_p.A114T	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	89	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		ACCTTCATGGCGTAGAGCTGC	0.502													17	85					0	0	0	0	T	166944753	T	T	166944753	3	4	73	1	0	0	0	0	1	0	0	0	13716	768	27	1	2012	1	RPS6KA2	6	166944753	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	12113554	166944753	4170314	59	14979											
ASNS	440	broad.mit.edu	37	chr7	97498327	97498327	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcaactaccgccaaccggtGaaatccaaagcagcagttgg	13	6	10	12	2	1	1	1	1	0	0	2	1	2	1	4	2	5	3	4	2	5	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr7:97498327G>C	uc003uot.3	-	3	648	c.142C>G	c.(142-144)CAC>GAC	p.H48D	ASNS_uc011kin.1_Intron|ASNS_uc003uou.3_Missense_Mutation_p.H48D|ASNS_uc003uov.3_Missense_Mutation_p.H48D|ASNS_uc011kio.1_Missense_Mutation_p.H27D|ASNS_uc003uow.3_Missense_Mutation_p.H27D|ASNS_uc003uox.3_Intron	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	48	Glutamine amidotransferase type-2.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCCAACCGGTGAAATCCAAAG	0.448													13	49					0	0	0	0	C	97498327	C	C	97498327	3	2	73	1	0	0	0	0	1	0	0	0	1050	1290	45	2	1587	2	ASNS	7	97498327	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08		97498327	61640336	60	14980											
LAMB4	22798	broad.mit.edu	37	chr7	107696162	107696162	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcctttctatttcagacaCgttccctctgaggtctttga	8	16	6	11	1	4	3	1	2	3	1	6	3	6	3	2	1	0	1	2	1	2	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr7:107696162C>A	uc010ljo.1	-	25	3754	c.3670G>T	c.(3670-3672)GTG>TTG	p.V1224L	LAMB4_uc003vey.2_Missense_Mutation_p.V1224L|LAMB4_uc010ljp.1_Missense_Mutation_p.V193L	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1224	Domain II.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						ATTTCAGACACGTTCCCTCTG	0.423													16	62					6.31663e-08	6.67873e-08	1	0	A	107696162	A	A	107696162	3	1	73	1	0	0	0	0	1	0	0	0	8653	536	19	3	1655	3	LAMB4	7	107696162	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	10197835	107696162	51442501	61	14981											
LAMB4	22798	broad.mit.edu	37	chr7	107696408	107696408	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcggcacatgcctgtgtctgGatcacagatgggcttctggg	6	10	15	10	1	3	1	1	0	2	1	3	2	3	2	1	4	1	2	1	4	0	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr7:107696408G>A	uc010ljo.1	-	25	3508	c.3424C>T	c.(3424-3426)CCA>TCA	p.P1142S	LAMB4_uc003vey.2_Missense_Mutation_p.P1142S|LAMB4_uc010ljp.1_Missense_Mutation_p.P111S	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1142	Laminin EGF-like 13.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						CCTGTGTCTGGATCACAGATG	0.532													8	36					0	0	0	0	A	107696408	A	A	107696408	3	1	73	1	0	0	0	0	1	0	0	0	8653	1174	41	2	1901	2	LAMB4	7	107696408	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	246	107696408	51442255	62	14982											
FAM110B	90362	broad.mit.edu	37	chr8	59059573	59059573	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctccagcggtctaagtcaGacttgagtgacagatatttc	10	11	9	11	1	2	4	1	2	1	2	4	4	3	4	2	1	1	0	2	1	2	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr8:59059573G>T	uc003xtj.1	+	5	1664	c.784G>T	c.(784-786)GAC>TAC	p.D262Y		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	262						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				GTCTAAGTCAGACTTGAGTGA	0.562													13	94					9.31168e-06	9.66087e-06	1	0	T	59059573	T	T	59059573	3	4	73	1	0	0	0	0	1	0	0	0	5425	942	33	2	786	2	FAM110B	8	59059573	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08		59059573	87304449	63	14983											
MAPK15	225689	broad.mit.edu	37	chr8	144802878	144802878	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacggcagcccacaggccacGacagacgctggatgccctcc	9	3	11	18	3	0	1	0	0	0	1	1	3	1	2	4	3	2	2	4	3	0	0			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr8:144802878G>A	uc003yzj.2	+	9	826	c.785G>A	c.(784-786)CGA>CAA	p.R262Q		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	262	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CACAGGCCACGACAGACGCTG	0.662													3	28					0	0	0	0	A	144802878	A	A	144802878	3	1	73	1	0	0	0	0	1	0	0	0	9330	1058	37	1	819	1	MAPK15	8	144802878	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	85743305	144802878	1561144	64	14984											
EXOSC4	54512	broad.mit.edu	37	chr8	145135305	145135305	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagccatgtggaggaagcagCtggtggcccccagctggccc	7	5	15	14	0	0	0	0	0	0	0	0	2	0	2	4	5	4	3	4	5	1	0			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr8:145135305C>T	uc003zau.2	+	3	649	c.539C>T	c.(538-540)GCT>GTT	p.A180V	GPAA1_uc003zav.1_5'Flank|GPAA1_uc003zaw.1_5'Flank|GPAA1_uc003zax.2_5'Flank	NM_019037	NP_061910	Q9NPD3	EXOS4_HUMAN	exosome component 4	180					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear mRNA surveillance|positive regulation of cell growth	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.48e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAGGAAGCAGCTGGTGGCCCC	0.657													7	64					0	0	0	0	T	145135305	T	T	145135305	3	4	73	1	0	0	0	0	1	0	0	0	5341	797	28	4	549	4	EXOSC4	8	145135305	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	332427	145135305	1228717	65	14985											
SMARCA2	6595	broad.mit.edu	37	chr9	2086833	2086833	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctcttgtgttatagattcGgtggaaatacatgatagtgg	10	15	11	5	1	1	2	0	1	1	1	3	3	2	3	1	3	1	1	1	3	5	6			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr9:2086833G>A	uc003zhc.2	+	18	2630	c.2531G>A	c.(2530-2532)CGG>CAG	p.R844Q	SMARCA2_uc003zhd.2_Missense_Mutation_p.R844Q|SMARCA2_uc010mha.2_Missense_Mutation_p.R835Q	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	844	Helicase ATP-binding.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TTATAGATTCGGTGGAAATAC	0.468													15	56					0	0	0	0	A	2086833	A	A	2086833	3	1	73	1	0	0	0	0	1	0	0	0	14833	1116	39	1	2597	1	SMARCA2	9	2086833	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08		2086833	139126598	66	14986											
ZCCHC6	79670	broad.mit.edu	37	chr9	88925620	88925620	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaagcctgaaaaaaatcttaCcaatgtgttatacaaactga	19	10	5	7	0	1	2	0	2	1	0	1	2	1	2	2	0	4	1	2	0	9	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr9:88925620C>T	uc004aoq.2	-	18	3593	c.3378_splice	c.e18+1	p.L1126_splice	ZCCHC6_uc010mqe.2_Splice_Site_p.L64_splice|ZCCHC6_uc011ltf.1_Intron|ZCCHC6_uc004aor.2_Splice_Site|ZCCHC6_uc004aos.2_Splice_Site|ZCCHC6_uc004aot.2_Splice_Site_p.L890_splice|ZCCHC6_uc004aou.2_Splice_Site_p.L1126_splice	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6						RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						AAAAATCTTACCAATGTGTTA	0.353													4	21					0	0	0	0	T	88925620	T	T	88925620	5	4	73	1	0	0	0	0	0	0	1	0	17659	521	18	4	1148	4	ZCCHC6	9	88925620	Splice_Site	SNP	C	TCGA-CN-6016-01A-11D-1683-08	86838787	88925620	52287811	67	14987											
FAM22F	54754	broad.mit.edu	37	chr9	97080990	97080990	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgagcagatggagactgAagagctccctggggtcctct	8	10	13	10	0	2	5	0	2	2	3	4	6	4	5	2	3	2	2	2	3	1	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr9:97080990A>T	uc004aup.1	-	7	2049	c.2028T>A	c.(2026-2028)CTT>CTA	p.L676L		NM_017561	NP_060031	A1L443	FA22F_HUMAN	hypothetical protein LOC54754	676											0		Acute lymphoblastic leukemia(62;0.136)				ATGGAGACTGAAGAGCTCCCT	0.612													5	15					0	0	0	0	T	97080990	T	T	97080990	2	4	73	1	0	0	0	0	0	0	0	1	5573	233	9	5		5	FAM22F	9	97080990	Silent	SNP	A	TCGA-CN-6016-01A-11D-1683-08	8155370	97080990	44132441	68	14988											
LPPR1	54886	broad.mit.edu	37	chr9	104071492	104071492	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgattttaaatcttcttataGgggtgtttgcatttggactt	8	20	9	4	0	2	1	0	1	2	0	2	2	2	2	0	3	1	2	0	3	4	8			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr9:104071492G>T	uc004bbb.2	+	5	785	c.386_splice	c.e5-1	p.G129_splice	LPPR1_uc011lvi.1_Splice_Site_p.G105_splice|LPPR1_uc004bbc.2_Splice_Site_p.G129_splice|LPPR1_uc010mtc.2_Splice_Site_p.G113_splice	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3							integral to membrane	catalytic activity				0						TCTTCTTATAGGGGTGTTTGC	0.413													11	99					6.40141e-05	6.60021e-05	1	0	T	104071492	T	T	104071492	5	4	73	1	0	0	0	0	0	0	1	0	8974	1014	35	4	399	4	LPPR1	9	104071492	Splice_Site	SNP	G	TCGA-CN-6016-01A-11D-1683-08	6990502	104071492	37141939	69	14989											
LPPR1	54886	broad.mit.edu	37	chr9	104071519	104071519	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgcatttggactttttgctActgacatttttgtaaacgcc	8	18	7	8	1	0	1	0	1	0	0	0	2	0	2	1	1	4	3	1	1	3	8			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr9:104071519A>T	uc004bbb.2	+	5	811	c.412A>T	c.(412-414)ACT>TCT	p.T138S	LPPR1_uc011lvi.1_Missense_Mutation_p.T114S|LPPR1_uc004bbc.2_Missense_Mutation_p.T138S|LPPR1_uc010mtc.2_Missense_Mutation_p.T122S	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	138	Helical; (Potential).					integral to membrane	catalytic activity				0						ACTTTTTGCTACTGACATTTT	0.418													13	92					0	0	0	0	T	104071519	T	T	104071519	3	4	73	1	0	0	0	0	1	0	0	0	8974	391	14	5	426	5	LPPR1	9	104071519	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	27	104071519	37141912	70	14990											
OR1N1	138883	broad.mit.edu	37	chr9	125289435	125289435	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggtgcaggtcagagccaatGgccaggatgatgagcaggtt	11	7	16	7	0	1	3	1	2	0	1	1	4	1	4	2	5	3	3	2	5	1	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr9:125289435G>A	uc004bmn.1	-	1	138	c.138C>T	c.(136-138)GCC>GCT	p.A46A		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	46	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						CAGAGCCAATGGCCAGGATGA	0.502													5	36					0	0	0	0	A	125289435	A	A	125289435	2	1	73	1	0	0	0	0	0	0	0	1	11023	1335	47	4		4	OR1N1	9	125289435	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08	21217916	125289435	15923996	71	14991											
SURF2	6835	broad.mit.edu	37	chr9	136226921	136226921	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatggacggtgacgggcctCgcccgcgggaagccttctgg	6	6	17	12	5	1	2	0	1	1	1	2	4	1	4	3	5	1	0	3	5	1	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr9:136226921C>T	uc004cdi.2	+	4	481	c.433C>T	c.(433-435)CGC>TGC	p.R145C		NM_017503	NP_059973	Q15527	SURF2_HUMAN	surfeit 2	145							protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		TGACGGGCCTCGCCCGCGGGA	0.627													4	15					0	0	0	0	T	136226921	T	T	136226921	3	4	73	1	0	0	0	0	1	0	0	0	15470	884	31	1	447	1	SURF2	9	136226921	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	10937486	136226921	4986510	72	14992											
NOTCH1	4851	broad.mit.edu	37	chr9	139401405	139401405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggggattgcagtcgtccaCgttgatctcacagtgcacac	8	9	13	11	2	1	1	1	1	1	0	4	2	2	2	1	3	2	3	1	3	0	2	rs112900950		TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr9:139401405C>T	uc004chz.2	-	23	3664	c.3664G>A	c.(3664-3666)GTG>ATG	p.V1222M	NOTCH1_uc004cia.1_Missense_Mutation_p.V452M	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1222	Extracellular (Potential).|EGF-like 32; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CAGTCGTCCACGTTGATCTCA	0.672			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			4	13					0	0	0	0	T	139401405	T	T	139401405	3	4	73	1	0	0	0	0	1	0	0	0	10601	536	19	1	4051	1	NOTCH1	9	139401405	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	3174484	139401405	1812026	73	14993											
C10orf18	54906	broad.mit.edu	37	chr10	5804550	5804550	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggaatccttgttacagaTgtaaataactttatagaaaa	17	13	7	4	0	0	2	0	0	0	2	1	3	1	3	1	1	2	2	1	1	9	7			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr10:5804550T>C	uc001iij.2	+	20	7855	c.7230T>C	c.(7228-7230)GAT>GAC	p.D2410D	C10orf18_uc001iik.2_Silent_p.D1254D	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2410										ovary(1)|central_nervous_system(1)	2						TTGTTACAGATGTAAATAACT	0.303													8	71					0	0	0	0	C	5804550	C	C	5804550	2	2	73	1	0	0	0	0	0	0	0	1	1602	1461	51	5		5	C10orf18	10	5804550	Silent	SNP	T	TCGA-CN-6016-01A-11D-1683-08		5804550	129730197	74	14994											
PCDH15	65217	broad.mit.edu	37	chr10	55700733	55700733	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagttcacttactggaggaGgtctgcaggtttagagaaga	12	10	13	6	0	2	2	1	0	1	2	2	5	2	4	0	4	2	3	0	4	4	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr10:55700733G>C	uc001jju.1	-	24	3520	c.3125C>G	c.(3124-3126)CCT>CGT	p.P1042R	PCDH15_uc010qhq.1_Missense_Mutation_p.P1047R|PCDH15_uc010qhr.1_Missense_Mutation_p.P1042R|PCDH15_uc010qhs.1_Missense_Mutation_p.P1054R|PCDH15_uc010qht.1_Missense_Mutation_p.P1049R|PCDH15_uc010qhu.1_Missense_Mutation_p.P1042R|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.P1042R|PCDH15_uc010qhw.1_Missense_Mutation_p.P1005R|PCDH15_uc010qhx.1_Missense_Mutation_p.P971R|PCDH15_uc010qhy.1_Missense_Mutation_p.P1047R|PCDH15_uc010qhz.1_Missense_Mutation_p.P1042R|PCDH15_uc010qia.1_Missense_Mutation_p.P1020R|PCDH15_uc010qib.1_Missense_Mutation_p.P1020R	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1042	Cadherin 10.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TACTGGAGGAGGTCTGCAGGT	0.269										HNSCC(58;0.16)			5	21					0	0	0	0	C	55700733	C	C	55700733	3	2	73	1	0	0	0	0	1	0	0	0	11565	1000	35	4	4401	4	PCDH15	10	55700733	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	49896183	55700733	79834014	75	14995											
TACR2	6865	broad.mit.edu	37	chr10	71166838	71166838	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggctggagtgggggctcAcctgtggttgagacagcagt	6	9	19	7	0	1	1	1	1	0	1	1	3	1	2	1	6	1	4	1	6	0	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr10:71166838A>G	uc001jpn.2	-	4	1533	c.938_splice	c.e4+1	p.R313_splice	TACR2_uc001jpm.2_Splice_Site_p.R101_splice	NM_001057	NP_001048	P21452	NK2R_HUMAN	tachykinin receptor 2						excretion|muscle contraction	integral to plasma membrane	tachykinin receptor activity			prostate(1)	1					Clonidine(DB00575)|Octreotide(DB00104)	GTGGGGGCTCACCTGTGGTTG	0.602													8	56					0	0	0	0	G	71166838	G	G	71166838	5	3	73	1	0	0	0	0	0	0	1	0	15572	173	6	5	264	5	TACR2	10	71166838	Splice_Site	SNP	A	TCGA-CN-6016-01A-11D-1683-08	15466105	71166838	64367909	76	14996											
RGR	5995	broad.mit.edu	37	chr10	86014100	86014100	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaacttcaccagcttcctCttcaccatgtccttcttcaa	10	13	3	15	0	5	1	3	0	2	1	7	1	7	1	4	0	2	1	4	0	2	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr10:86014100C>G	uc001kdc.1	+	5	569	c.531C>G	c.(529-531)CTC>CTG	p.L177L	RGR_uc001kdd.1_Silent_p.L181L|RGR_uc001kde.1_Silent_p.L177L	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	177	Helical; Name=5; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						CCAGCTTCCTCTTCACCATGT	0.562													7	68					0	0	0	0	G	86014100	G	G	86014100	2	3	73	1	0	0	0	0	0	0	0	1	13356	900	32	2		2	RGR	10	86014100	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	14847262	86014100	49520647	77	14997											
PDZD8	118987	broad.mit.edu	37	chr10	119049706	119049706	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcataattacctccaatggCgataagtcgatctccccgct	11	10	7	13	3	1	0	0	0	1	0	4	2	2	0	4	1	2	2	4	1	4	3	rs150304837		TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr10:119049706C>T	uc001lde.1	-	4	1451	c.1252G>A	c.(1252-1254)GCC>ACC	p.A418T		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	418	PDZ.				intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		CCTCCAATGGCGATAAGTCGA	0.423													13	47					0	0	0	0	T	119049706	T	T	119049706	3	4	73	1	0	0	0	0	1	0	0	0	11759	768	27	1	2220	1	PDZD8	10	119049706	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	33035606	119049706	16485041	78	14998											
GRK5	2869	broad.mit.edu	37	chr10	121156241	121156241	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tactccagatgaaaaactggGagagaaagggaaggaaatta	19	6	12	4	0	0	3	0	1	0	2	1	7	1	6	1	3	2	0	1	3	7	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr10:121156241G>A	uc001led.2	+	4	529	c.296G>A	c.(295-297)GGA>GAA	p.G99E	GRK5_uc009xzh.2_5'UTR|GRK5_uc010qta.1_5'UTR	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	99	N-terminal.|RGS.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GAAAAACTGGGAGAGAAAGGG	0.393													13	75					0	0	0	0	A	121156241	A	A	121156241	3	1	73	1	0	0	0	0	1	0	0	0	6831	1174	41	2	310	2	GRK5	10	121156241	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	2106535	121156241	14378506	79	14999											
RIC8A	60626	broad.mit.edu	37	chr11	209868	209868	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaactgacacactggagctGacgctgggggtgactcctga	9	8	13	11	1	0	4	0	4	0	0	1	5	1	5	1	3	2	2	1	3	1	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:209868G>A	uc001log.2	+	3	919	c.594G>A	c.(592-594)CTG>CTA	p.L198L	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Silent_p.L198L|RIC8A_uc001loh.2_Silent_p.L191L	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	198						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CACTGGAGCTGACGCTGGGGG	0.597													12	47					0	0	0	0	A	209868	A	A	209868	2	1	73	1	0	0	0	0	0	0	0	1	13420	1277	45	2		2	RIC8A	11	209868	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08		209868	134796648	80	15000											
PDDC1	347862	broad.mit.edu	37	chr11	773582	773582	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccactgctggccaggtcggTcagggccccaggacagctgg	6	5	16	14	1	1	0	1	0	0	0	2	1	1	1	4	6	2	2	4	6	0	0			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:773582T>C	uc001lrc.2	-	4	320	c.295A>G	c.(295-297)ACC>GCC	p.T99A	PDDC1_uc010qwm.1_Missense_Mutation_p.T49A|PDDC1_uc001lrd.2_Missense_Mutation_p.T99A|PDDC1_uc001lrf.1_Intron|PDDC1_uc001lrg.1_Intron|PDDC1_uc009ycg.2_Missense_Mutation_p.T49A|PDDC1_uc010qwn.1_RNA|PDDC1_uc010qwo.1_RNA|PDDC1_uc010qwp.1_Intron|PDDC1_uc010qwq.1_Intron|PDDC1_uc010qwr.1_Missense_Mutation_p.T99A|PDDC1_uc010qws.1_Missense_Mutation_p.T49A	NM_182612	NP_872418	Q8NB37	PDDC1_HUMAN	Parkinson disease 7 domain containing 1	99						extracellular region					0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;3.66e-26)|Epithelial(43;2.43e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-19)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCAGGTCGGTCAGGGCCCCA	0.637													3	21					0	0	0	0	C	773582	C	C	773582	3	2	73	1	0	0	0	0	1	0	0	0	11683	1667	58	5	387	5	PDDC1	11	773582	Missense_Mutation	SNP	T	TCGA-CN-6016-01A-11D-1683-08	563714	773582	134232934	81	15001											
MUC15	143662	broad.mit.edu	37	chr11	26587071	26587071	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaaacaaagctatggatcAagggagggcttgtggaaatg	15	8	14	4	0	1	1	1	0	0	1	1	4	1	4	0	4	2	2	0	4	6	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:26587071A>G	uc001mqx.2	-	2	601	c.335T>C	c.(334-336)TTG>TCG	p.L112S	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.L139S|MUC15_uc001mqy.2_Missense_Mutation_p.L139S	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	112	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCTATGGATCAAGGGAGGGCT	0.453													6	93					0	0	0	0	G	26587071	G	G	26587071	3	3	73	1	0	0	0	0	1	0	0	0	10025	131	5	5	681	5	MUC15	11	26587071	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	25813489	26587071	108419445	82	15002											
C11orf41	25758	broad.mit.edu	37	chr11	33620472	33620472	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cacagcagaaagtgacaaagGaggaggcaaggaagagaaat	20	2	14	5	0	0	3	0	1	0	2	0	7	0	6	0	4	1	2	0	4	5	0			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:33620472G>C	uc001mup.3	+	12	4109	c.3985G>C	c.(3985-3987)GAG>CAG	p.E1329Q	C11orf41_uc001mun.1_3'UTR	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1323						integral to membrane				ovary(2)	2						AGTGACAAAGGAGGAGGCAAG	0.577													5	22					0	0	0	0	C	33620472	C	C	33620472	3	2	73	1	0	0	0	0	1	0	0	0	1646	1175	41	2	4031	2	C11orf41	11	33620472	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	7033401	33620472	101386044	83	15003											
ARHGAP1	392	broad.mit.edu	37	chr11	46702656	46702656	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatcttctgcccgaacttGaagctgttggtggaagaaag	12	10	12	7	1	2	3	0	1	2	2	2	5	2	4	1	2	3	2	1	2	5	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:46702656G>T	uc001ndd.2	-	7	609	c.540C>A	c.(538-540)TTC>TTA	p.F180L		NM_004308	NP_004299	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	180	CRAL-TRIO.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			skin(1)	1		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		GCCCGAACTTGAAGCTGTTGG	0.602													4	42					0.00909568	0.0092066	1	0	T	46702656	T	T	46702656	3	4	73	1	0	0	0	0	1	0	0	0	861	1281	45	2	807	2	ARHGAP1	11	46702656	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	13082184	46702656	88303860	84	15004											
CKAP5	9793	broad.mit.edu	37	chr11	46771969	46771969	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatttcttcttatattcataTaactctgctagtccctggtg	8	19	5	9	0	4	0	1	0	3	0	5	0	5	0	1	1	2	1	1	1	6	9			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:46771969T>C	uc001ndi.1	-	42	5669	c.5559A>G	c.(5557-5559)TTA>TTG	p.L1853L	CKAP5_uc009ylg.1_Silent_p.L1746L|CKAP5_uc001ndj.1_Silent_p.L1793L|CKAP5_uc001ndh.1_Silent_p.L782L	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1853					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TATATTCATATAACTCTGCTA	0.428													15	51					0	0	0	0	C	46771969	C	C	46771969	2	2	73	1	0	0	0	0	0	0	0	1	3460	1403	49	5		5	CKAP5	11	46771969	Silent	SNP	T	TCGA-CN-6016-01A-11D-1683-08	69313	46771969	88234547	85	15005											
MADD	8567	broad.mit.edu	37	chr11	47305742	47305742	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgcagtggcagtgatagtAtggattatgacgattcaagc	11	12	12	6	1	2	2	1	2	1	0	2	4	2	3	0	2	2	3	0	2	4	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:47305742A>G	uc001ner.1	+	11	2067	c.1876A>G	c.(1876-1878)ATG>GTG	p.M626V	MADD_uc001neq.2_Missense_Mutation_p.M626V|MADD_uc001nev.1_Missense_Mutation_p.M626V|MADD_uc001nes.1_Missense_Mutation_p.M626V|MADD_uc001net.1_Missense_Mutation_p.M626V|MADD_uc009yln.1_Missense_Mutation_p.M626V|MADD_uc001neu.1_Missense_Mutation_p.M626V|MADD_uc001nex.2_Missense_Mutation_p.M626V|MADD_uc001nez.2_Missense_Mutation_p.M626V|MADD_uc001new.2_Missense_Mutation_p.M626V	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	626					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		CAGTGATAGTATGGATTATGA	0.423													16	93					0	0	0	0	G	47305742	G	G	47305742	3	3	73	1	0	0	0	0	1	0	0	0	9203	449	16	5	1914	5	MADD	11	47305742	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	533773	47305742	87700774	86	15006											
RCOR2	283248	broad.mit.edu	37	chr11	63681511	63681511	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcctgacactgccgtgaggCcttcagggctcaggtacatg	7	10	12	12	1	2	2	2	2	0	0	3	2	3	2	3	3	2	2	3	3	1	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:63681511C>T	uc001nyc.2	-	8	1194	c.806G>A	c.(805-807)GGC>GAC	p.G269D		NM_173587	NP_775858	Q8IZ40	RCOR2_HUMAN	REST corepressor 2	269					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)|skin(1)	2						TGCCGTGAGGCCTTCAGGGCT	0.642													17	129					0	0	0	0	T	63681511	T	T	63681511	3	4	73	1	0	0	0	0	1	0	0	0	13248	739	26	4	785	4	RCOR2	11	63681511	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	16375769	63681511	71325005	87	15007											
UVRAG	7405	broad.mit.edu	37	chr11	75826972	75826972	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttcaccttcacagctaaGatatcaacatggactaggga	13	12	7	9	0	3	1	3	0	0	1	3	3	3	3	1	2	2	1	1	2	4	6			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:75826972G>A	uc001oxc.2	+	14	1551	c.1310G>A	c.(1309-1311)AGA>AAA	p.R437K	UVRAG_uc010rrw.1_Missense_Mutation_p.R336K|UVRAG_uc001oxd.2_Missense_Mutation_p.R65K|UVRAG_uc010rrx.1_Missense_Mutation_p.R65K|UVRAG_uc010rry.1_5'UTR	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	437					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						TCACAGCTAAGATATCAACAT	0.373													5	25					0	0	0	0	A	75826972	A	A	75826972	3	1	73	1	0	0	0	0	1	0	0	0	17176	942	33	2	1364	2	UVRAG	11	75826972	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	12145461	75826972	59179544	88	15008											
NOX4	50507	broad.mit.edu	37	chr11	89223667	89223667	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgatactctggcccttggtTatacagcaagaaggttttcc	9	13	10	9	0	1	2	0	1	1	1	2	2	2	2	2	3	3	3	2	3	5	6			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:89223667T>C	uc001pct.2	-	2	351	c.112A>G	c.(112-114)AAC>GAC	p.N38D	NOX4_uc009yvr.2_Intron|NOX4_uc001pcu.2_Translation_Start_Site|NOX4_uc001pcw.2_Missense_Mutation_p.N38D|NOX4_uc001pcx.2_Missense_Mutation_p.N38D|NOX4_uc001pcv.2_Missense_Mutation_p.N38D|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Translation_Start_Site|NOX4_uc009yvp.2_Missense_Mutation_p.N38D|NOX4_uc010rtv.1_Missense_Mutation_p.N14D|NOX4_uc009yvq.2_Missense_Mutation_p.N14D|NOX4_uc009yvs.1_RNA|NOX4_uc001pcy.2_RNA	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	38	Extracellular (Potential).				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				GGCCCTTGGTTATACAGCAAG	0.418													15	63					0	0	0	0	C	89223667	C	C	89223667	3	2	73	1	0	0	0	0	1	0	0	0	10612	1754	61	5	1692	5	NOX4	11	89223667	Missense_Mutation	SNP	T	TCGA-CN-6016-01A-11D-1683-08	13396695	89223667	45782849	89	15009											
RNF214	257160	broad.mit.edu	37	chr11	117109781	117109781	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgagtggatcaggatgatgAtcaagatagctcttccctga	11	10	11	9	1	3	4	2	3	1	1	4	7	4	6	2	2	1	1	2	2	2	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr11:117109781A>T	uc001pqt.2	+	3	617	c.572A>T	c.(571-573)GAT>GTT	p.D191V	RNF214_uc001pqu.2_Missense_Mutation_p.D191V|RNF214_uc010rxf.1_Intron	NM_207343	NP_997226	Q8ND24	RN214_HUMAN	ring finger protein 214	191							zinc ion binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		CAGGATGATGATCAAGATAGC	0.468													13	75					0	0	0	0	T	117109781	T	T	117109781	3	4	73	1	0	0	0	0	1	0	0	0	13543	333	12	5	578	5	RNF214	11	117109781	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	27886114	117109781	17896735	90	15010											
VWF	7450	broad.mit.edu	37	chr12	6078430	6078430	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacagctcagctgaaagcccGaggggcagacagggacctcc	11	4	13	13	1	1	2	1	1	0	1	2	4	2	3	3	3	4	3	3	3	2	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr12:6078430G>A	uc001qnn.1	-	45	7926	c.7676C>T	c.(7675-7677)TCG>TTG	p.S2559L	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2559					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CTGAAAGCCCGAGGGGCAGAC	0.592													4	49					0	0	0	0	A	6078430	A	A	6078430	3	1	73	1	0	0	0	0	1	0	0	0	17314	1059	37	1	797	1	VWF	12	6078430	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08		6078430	127773465	91	15011											
CLEC4E	26253	broad.mit.edu	37	chr12	8687355	8687355	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgaagagtctctcatggtgGcacagtcctccagggtagct	8	11	12	10	0	2	2	1	1	1	1	5	2	4	2	2	3	1	3	2	3	2	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr12:8687355G>A	uc001quo.1	-	6	704	c.539C>T	c.(538-540)GCC>GTC	p.A180V		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	180	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					TCTCATGGTGGCACAGTCCTC	0.413													18	55					0	0	0	0	A	8687355	A	A	8687355	3	1	73	1	0	0	0	0	1	0	0	0	3530	1203	42	4	124	4	CLEC4E	12	8687355	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	2608925	8687355	125164540	92	15012											
KLHDC5	57542	broad.mit.edu	37	chr12	27950650	27950650	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctttctttctttcagacCggaacatgaacattttgcag	9	16	7	9	1	4	2	1	1	3	1	4	3	4	3	1	1	3	1	1	1	2	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr12:27950650C>T	uc001rij.2	+	3	1146	c.1069C>T	c.(1069-1071)CGG>TGG	p.R357W	KLHDC5_uc009zjj.2_RNA	NM_020782	NP_065833	Q9P2K6	KLDC5_HUMAN	kelch domain containing 5	357	Kelch 4.									ovary(1)|central_nervous_system(1)	2	Lung SC(9;0.0873)					TCTTTCAGACCGGAACATGAA	0.473													45	328					0	0	0	0	T	27950650	T	T	27950650	3	4	73	1	0	0	0	0	1	0	0	0	8398	643	23	1	1079	1	KLHDC5	12	27950650	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	19263295	27950650	105901245	93	15013											
SOAT2	8435	broad.mit.edu	37	chr12	53516967	53516967	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcgtcctggggttcttctatCccgtcatgctgatactcttc	4	16	8	13	2	4	1	1	1	3	0	8	1	6	1	2	2	2	2	2	2	2	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr12:53516967C>T	uc001sbv.2	+	13	1427	c.1339C>T	c.(1339-1341)CCC>TCC	p.P447S	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	447	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						GTTCTTCTATCCCGTCATGCT	0.592													11	52					0	0	0	0	T	53516967	T	T	53516967	3	4	73	1	0	0	0	0	1	0	0	0	14975	855	30	2	1389	2	SOAT2	12	53516967	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	25566317	53516967	80334928	94	15014											
MBD6	114785	broad.mit.edu	37	chr12	57920022	57920022	+	Frame_Shift_Del	DEL	C	-	-																															actccccacccctggcccttCccactctgatggaagcttta																										TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr12:57920022delC	uc001soj.1	+	6	1495	c.1271delC	c.(1270-1272)TCCfs	p.S424fs	MBD6_uc001sok.1_Frame_Shift_Del_p.S291fs|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	424	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCTGGCCCTTCCCACTCTGAT	0.627													---	---	---								-	57920022	-	-	57920022	7	5	73	1	0	1	0	1	0	0	0	0	9401	855	30	0	1285	0	MBD6	12	57920022	Frame_Shift_Del	DEL	C	TCGA-CN-6016-01A-11D-1683-08	4403055	57920022	75931873	95	15015											
USP15	9958	broad.mit.edu	37	chr12	62785134	62785134	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cattccagttcaacaacttaGgcaatactgatatcaactac	15	11	4	11	0	2	1	2	1	0	0	3	1	3	1	1	1	5	2	1	1	8	6	rs7358652		TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr12:62785134G>C	uc001src.1	+	16	2167	c.2158G>C	c.(2158-2160)GGC>CGC	p.G720R	USP15_uc001srb.1_Missense_Mutation_p.G691R	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	720					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		CAACAACTTAGGCAATACTGA	0.358													12	83					0	0	0	0	C	62785134	C	C	62785134	3	2	73	1	0	0	0	0	1	0	0	0	17114	1000	35	4	2129	4	USP15	12	62785134	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	4865112	62785134	71066761	96	15016											
C12orf51	283450	broad.mit.edu	37	chr12	112610649	112610649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccttctgtgcatgtcggaCatcgatgcatgcgcaccttg	6	11	12	12	3	1	0	0	0	1	0	3	2	1	1	2	2	3	3	2	2	0	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr12:112610649C>T	uc009zwc.2	-	60	10363	c.10345G>A	c.(10345-10347)GTC>ATC	p.V3449I		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GCATGTCGGACATCGATGCAT	0.587													7	61					0	0	0	0	T	112610649	T	T	112610649	3	4	73	1	0	0	0	0	1	0	0	0	1702	478	17	4	1685	4	C12orf51	12	112610649	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	49825515	112610649	21241246	97	15017											
C12orf51	283450	broad.mit.edu	37	chr12	112666473	112666473	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgatcttggaacacaaagtCtagacaatggaatagtcaat	16	10	8	7	0	3	2	1	1	2	1	3	4	3	4	0	2	1	0	0	2	7	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr12:112666473C>T	uc009zwc.2	-	35	5414	c.5396G>A	c.(5395-5397)AGA>AAA	p.R1799K	C12orf51_uc001ttr.1_5'Flank	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						AACACAAAGTCTAGACAATGG	0.398													6	58					0	0	0	0	T	112666473	T	T	112666473	3	4	73	1	0	0	0	0	1	0	0	0	1702	913	32	2	6734	2	C12orf51	12	112666473	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	55824	112666473	21185422	98	15018											
DCLK1	9201	broad.mit.edu	37	chr13	36700050	36700050	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggaaccggtctggggagatGgcatacacaatccctttgaa	11	8	12	10	2	1	2	0	1	1	1	2	4	2	3	2	5	2	1	2	5	4	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr13:36700050G>A	uc001uvf.2	-	2	458	c.225C>T	c.(223-225)GCC>GCT	p.A75A		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	75	Doublecortin 1.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CTGGGGAGATGGCATACACAA	0.527													12	56					0	0	0	0	A	36700050	A	A	36700050	2	1	73	1	0	0	0	0	0	0	0	1	4308	1335	47	4		4	DCLK1	13	36700050	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08		36700050	78469828	99	15019											
F7	2155	broad.mit.edu	37	chr13	113773175	113773175	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccggggcacgtggtacctGacgggcatcgtcagctgggg	6	7	17	11	4	1	1	1	1	0	0	2	1	1	1	2	6	3	4	2	6	2	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr13:113773175G>A	uc001vsv.2	+	9	1305	c.1254G>A	c.(1252-1254)CTG>CTA	p.L418L	F7_uc001vsw.2_Silent_p.L396L|F7_uc010tjt.1_Silent_p.L349L	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	418	Peptidase S1.				anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	CGTGGTACCTGACGGGCATCG	0.627													8	18					0	0	0	0	A	113773175	A	A	113773175	2	1	73	1	0	0	0	0	0	0	0	1	5374	1277	45	2		2	F7	13	113773175	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08	77073125	113773175	1396703	100	15020											
PRMT5	10419	broad.mit.edu	37	chr14	23397351	23397351	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaccgcctcggagttcctgCgaatcttctccacttttgag	6	14	8	13	3	2	1	0	1	2	0	5	3	3	2	4	1	2	1	4	1	2	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr14:23397351C>T	uc001whm.1	-	3	390	c.299G>A	c.(298-300)CGC>CAC	p.R100H	PRMT5_uc001whl.1_Missense_Mutation_p.R83H|PRMT5_uc010akd.1_RNA|PRMT5_uc010tnf.1_5'UTR|PRMT5_uc010tng.1_Intron|PRMT5_uc010tnh.1_Intron|PRMT5_uc001whn.1_Missense_Mutation_p.R83H	NM_006109	NP_006100	O14744	ANM5_HUMAN	protein arginine methyltransferase 5 isoform a	100					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			ovary(1)	1	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		GGAGTTCCTGCGAATCTTCTC	0.498													5	40					0	0	0	0	T	23397351	T	T	23397351	3	4	73	1	0	0	0	0	1	0	0	0	12601	768	27	1	1674	1	PRMT5	14	23397351	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08		23397351	83952189	101	15021											
NIN	51199	broad.mit.edu	37	chr14	51192739	51192739	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcagtttctgttcaacttCtatcattcgttcctccatga	7	19	4	11	1	5	1	3	1	2	0	8	1	7	1	2	0	1	3	2	0	2	7			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr14:51192739C>T	uc001wym.2	-	30	6315	c.6124G>A	c.(6124-6126)GAA>AAA	p.E2042K	NIN_uc001wyi.2_Missense_Mutation_p.E2042K|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.E1329K|NIN_uc010tqp.1_Missense_Mutation_p.E2048K	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	2042	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TGTTCAACTTCTATCATTCGT	0.413			T	PDGFRB	MPD								11	66					0	0	0	0	T	51192739	T	T	51192739	3	4	73	1	0	0	0	0	1	0	0	0	10471	922	32	2	366	2	NIN	14	51192739	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	27795388	51192739	56156801	102	15022											
NID2	22795	broad.mit.edu	37	chr14	52520909	52520909	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagggctgtagcatggctgaAggaacgtcccaggggaacag	11	5	16	9	1	0	1	0	1	0	0	1	3	1	3	1	5	3	4	1	5	4	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr14:52520909A>G	uc001wzo.2	-	4	1132	c.898T>C	c.(898-900)TTC>CTC	p.F300L	NID2_uc010tqs.1_Missense_Mutation_p.F300L|NID2_uc010tqt.1_Missense_Mutation_p.F300L|NID2_uc001wzp.2_Missense_Mutation_p.F300L	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	300						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GCATGGCTGAAGGAACGTCCC	0.517													6	17					0	0	0	0	G	52520909	G	G	52520909	3	3	73	1	0	0	0	0	1	0	0	0	10469	72	3	5	3305	5	NID2	14	52520909	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	1328170	52520909	54828631	103	15023											
DYNC1H1	1778	broad.mit.edu	37	chr14	102452228	102452228	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgaagaggtacgatgagAggatcgacagagtggagacc	14	6	15	6	2	0	5	0	2	0	4	1	10	0	6	1	3	1	1	1	3	3	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr14:102452228A>T	uc001yks.2	+	8	1830	c.1666A>T	c.(1666-1668)AGG>TGG	p.R556W		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	556	Interaction with DYNC1I2 (By similarity).|Stem (By similarity).|Potential.				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GTACGATGAGAGGATCGACAG	0.512													12	35					0	0	0	0	T	102452228	T	T	102452228	3	4	73	1	0	0	0	0	1	0	0	0	4863	295	11	5	1696	5	DYNC1H1	14	102452228	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	49931319	102452228	4897312	104	15024											
SPESP1	246777	broad.mit.edu	37	chr15	69238891	69238891	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattaaaaaatatgtgtagaTcaaggagagtcacagcctta	17	10	8	6	0	2	2	2	0	0	2	2	3	2	2	1	1	1	1	1	1	7	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr15:69238891T>C	uc002arn.1	+	2	1146	c.1018T>C	c.(1018-1020)TCA>CCA	p.S340P	NOX5_uc002arp.1_Intron|NOX5_uc002arq.1_Intron|NOX5_uc010bid.1_Intron|NOX5_uc002aro.2_Intron	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	340					multicellular organismal development	acrosomal vesicle					0						TATGTGTAGATCAAGGAGAGT	0.264													10	40					0	0	0	0	C	69238891	C	C	69238891	3	2	73	1	0	0	0	0	1	0	0	0	15106	1435	50	5	1024	5	SPESP1	15	69238891	Missense_Mutation	SNP	T	TCGA-CN-6016-01A-11D-1683-08		69238891	33292501	105	15025											
FAM108C1	58489	broad.mit.edu	37	chr15	81046631	81046631	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctttgggttgaaggggctGggcataatgacatagagctt	9	11	14	7	0	0	3	0	2	0	1	0	3	0	3	1	4	1	4	1	4	3	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr15:81046631G>A	uc002bfu.2	+	3	1029	c.910G>A	c.(910-912)GGG>AGG	p.G304R	FAM108C1_uc002bft.2_Missense_Mutation_p.G263R	NM_021214	NP_067037	Q6PCB6	F108C_HUMAN	hypothetical protein LOC58489	304							hydrolase activity				0						TGAAGGGGCTGGGCATAATGA	0.473													3	38					0	0	0	0	A	81046631	A	A	81046631	3	1	73	1	0	0	0	0	1	0	0	0	5421	1348	47	4	920	4	FAM108C1	15	81046631	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	11807740	81046631	21484761	106	15026											
SNRPA1	6627	broad.mit.edu	37	chr15	101821964	101821964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactgtgtcttcttccatctCttcttcaccatcatcagtgg	6	16	6	13	0	7	0	3	0	4	0	9	1	8	0	2	1	0	0	2	1	0	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr15:101821964C>T	uc002bww.2	-	9	810	c.733G>A	c.(733-735)GAG>AAG	p.E245K	SNRPA1_uc002bwx.2_RNA|SNRPA1_uc010bpc.2_RNA	NM_003090	NP_003081	P09661	RU2A_HUMAN	small nuclear ribonucleoprotein polypeptide A'	245						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	protein binding|RNA binding			kidney(1)	1	Lung NSC(78;0.00156)|all_lung(78;0.00195)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00113)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TCTTCCATCTCTTCTTCACCA	0.348													12	37					0	0	0	0	T	101821964	T	T	101821964	3	4	73	1	0	0	0	0	1	0	0	0	14924	922	32	2	38	2	SNRPA1	15	101821964	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	20775333	101821964	709428	107	15027											
ZNF598	90850	broad.mit.edu	37	chr16	2052728	2052728	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccacttgcgctcatatgtGaagatctacaaggcacagga	13	9	9	10	1	2	2	1	1	1	1	2	3	2	3	1	2	3	2	1	2	5	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr16:2052728G>A	uc002cof.1	-	6	486	c.471C>T	c.(469-471)TTC>TTT	p.F157F	ZNF598_uc002coe.1_5'Flank	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	157						intracellular	zinc ion binding			lung(1)|breast(1)	2						GCTCATATGTGAAGATCTACA	0.657													3	10					0	0	0	0	A	2052728	A	A	2052728	2	1	73	1	0	0	0	0	0	0	0	1	18095	1281	45	2		2	ZNF598	16	2052728	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08		2052728	88302025	108	15028											
XYLT1	64131	broad.mit.edu	37	chr16	17221565	17221565	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagtcactgggtgggcttgcGatcttgaagacttttttcgg	7	14	13	7	2	2	2	1	1	1	1	3	3	2	2	0	3	1	1	0	3	2	5	rs112238716		TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr16:17221565G>A	uc002dfa.2	-	10	2266	c.2181C>T	c.(2179-2181)ATC>ATT	p.I727I		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	727	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GTGGGCTTGCGATCTTGAAGA	0.493													28	145					0	0	0	0	A	17221565	A	A	17221565	2	1	73	1	0	0	0	0	0	0	0	1	17531	1048	37	1		1	XYLT1	16	17221565	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08	15168837	17221565	73133188	109	15029											
SMG1	23049	broad.mit.edu	37	chr16	18840717	18840717	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttccaggcagtgtcgtaaGaacttgctaacacagttgcc	10	11	9	11	1	1	1	0	0	1	1	3	1	2	1	2	1	4	4	2	1	3	5			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr16:18840717G>C	uc002dfm.2	-	54	9857	c.9494C>G	c.(9493-9495)TCT>TGT	p.S3165C	SMG1_uc010bwb.2_Missense_Mutation_p.S3025C|SMG1_uc010bwa.2_Missense_Mutation_p.S1896C	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3165					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						AGTGTCGTAAGAACTTGCTAA	0.463													3	41					0	0	0	0	C	18840717	C	C	18840717	3	2	73	1	0	0	0	0	1	0	0	0	14859	942	33	2	1531	2	SMG1	16	18840717	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	1619152	18840717	71514036	110	15030											
NUPR1	26471	broad.mit.edu	37	chr16	28549476	28549476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gacctttccggcctccacctCctgtaaccaaggcaggagtc	8	8	9	16	1	0	0	0	0	0	0	4	2	3	1	7	3	1	2	7	3	2	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr16:28549476C>T	uc002dqe.1	-	2	380	c.113G>A	c.(112-114)GGA>GAA	p.G38E	uc010vct.1_Intron|NUPR1_uc002dqd.1_Missense_Mutation_p.G56E	NM_012385	NP_036517	O60356	NUPR1_HUMAN	p8 protein isoform b	38					cell growth|induction of apoptosis	nucleus					0						GCCTCCACCTCCTGTAACCAA	0.612													18	103					0	0	0	0	T	28549476	T	T	28549476	3	4	73	1	0	0	0	0	1	0	0	0	10830	869	30	2	139	2	NUPR1	16	28549476	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	9708759	28549476	61805277	111	15031											
SALL1	6299	broad.mit.edu	37	chr16	51175973	51175973	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcagaagatctgataattCaaagaactcggcacagcacc	16	6	9	10	1	2	4	1	1	1	3	3	5	2	4	1	1	3	3	1	1	4	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr16:51175973C>T	uc010vgs.1	-	2	191	c.160G>A	c.(160-162)GAA>AAA	p.E54K	SALL1_uc010vgr.1_5'UTR|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	54					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TCTGATAATTCAAAGAACTCG	0.458													20	119					0	0	0	0	T	51175973	T	T	51175973	3	4	73	1	0	0	0	0	1	0	0	0	13875	835	29	2	3822	2	SALL1	16	51175973	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	22626497	51175973	39178780	112	15032											
HAS3	3038	broad.mit.edu	37	chr16	69148735	69148735	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggccgcatctggaacattCtcctcttcctgctgacggtg	5	11	12	13	2	3	1	0	1	3	0	5	2	4	2	3	4	2	2	3	4	1	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr16:69148735C>G	uc010cfh.2	+	4	1452	c.1228C>G	c.(1228-1230)CTC>GTC	p.L410V	HAS3_uc002ewk.2_Intron|HAS3_uc002ewl.2_Missense_Mutation_p.L410V	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	410	Helical; Name=4; (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		CTGGAACATTCTCCTCTTCCT	0.547													4	94					0	0	0	0	G	69148735	G	G	69148735	3	3	73	1	0	0	0	0	1	0	0	0	7002	913	32	2	1238	2	HAS3	16	69148735	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	17972762	69148735	21206018	113	15033											
MARVELD3	91862	broad.mit.edu	37	chr16	71674673	71674673	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtttacctccacgtggctCtgcagatcaatagcaccgac	9	10	9	13	2	2	1	1	0	1	1	3	2	3	1	3	1	3	4	3	1	3	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr16:71674673C>T	uc002fau.2	+	3	1039	c.976C>T	c.(976-978)CTG>TTG	p.L326L	PHLPP2_uc002fav.2_RNA|MARVELD3_uc010cge.2_3'UTR	NM_001017967	NP_001017967	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane				skin(1)	1		Ovarian(137;0.125)				CCACGTGGCTCTGCAGATCAA	0.587													4	48					0	0	0	0	T	71674673	T	T	71674673	2	4	73	1	0	0	0	0	0	0	0	1	9372	912	32	2		2	MARVELD3	16	71674673	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	2525938	71674673	18680080	114	15034											
CHST6	4166	broad.mit.edu	37	chr16	75513583	75513583	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggacgagcccgagcgccaCgaggacagcaccagcacatg	13	1	13	14	4	0	0	0	0	0	0	0	5	0	2	3	2	4	2	3	2	1	0			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr16:75513583C>T	uc002fef.2	-	3	324	c.144G>A	c.(142-144)TCG>TCA	p.S48S	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.S48S	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	48	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						CCGAGCGCCACGAGGACAGCA	0.672													3	21					0	0	0	0	T	75513583	T	T	75513583	2	4	73	1	0	0	0	0	0	0	0	1	3423	523	19	1		1	CHST6	16	75513583	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	3838910	75513583	14841170	115	15035											
OR3A1	4994	broad.mit.edu	37	chr17	3195220	3195220	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgccacgtggatataggaGatgacaatgagagccatggg	12	7	15	7	1	0	3	0	2	0	2	0	6	0	4	2	3	2	1	2	3	3	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr17:3195220G>C	uc002fvh.1	-	1	657	c.657C>G	c.(655-657)ATC>ATG	p.I219M		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	219	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						GGATATAGGAGATGACAATGA	0.537													12	26					0	0	0	0	C	3195220	C	C	3195220	3	2	73	1	0	0	0	0	1	0	0	0	11091	932	33	2	294	2	OR3A1	17	3195220	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08		3195220	77999990	116	15036											
TRPV3	162514	broad.mit.edu	37	chr17	3417907	3417907	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgttcgtcttacaggccccGggtcttcgttaaggaaggag	7	11	13	10	3	2	0	0	0	2	0	4	2	2	2	2	4	1	2	2	4	3	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr17:3417907G>A	uc002fvt.1	-	17	2580	c.2258C>T	c.(2257-2259)CCG>CTG	p.P753L	SPATA22_uc010vrg.1_5'Flank|TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Missense_Mutation_p.P737L|TRPV3_uc010vri.1_Missense_Mutation_p.P708L|TRPV3_uc010vrj.1_Missense_Mutation_p.P737L|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Missense_Mutation_p.P737L|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Missense_Mutation_p.P753L|TRPV3_uc002fvu.2_Missense_Mutation_p.P753L	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	753	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	TACAGGCCCCGGGTCTTCGTT	0.408													7	25					0	0	0	0	A	3417907	A	A	3417907	3	1	73	1	0	0	0	0	1	0	0	0	16664	1116	39	1	122	1	TRPV3	17	3417907	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	222687	3417907	77777303	117	15037											
TP53	7157	broad.mit.edu	37	chr17	7577548	7577548	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgggcctccggttcatgcCgcccatgcaggaactgttac	7	9	12	13	2	1	0	1	0	0	0	2	2	2	1	4	3	4	3	4	3	2	2	rs28934575		TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	39					0	0	0	0	T	7577548	T	T	7577548	3	4	73	1	0	0	0	0	1	0	0	0	16448	652	23	1	557	1	TP53	17	7577548	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	4159641	7577548	73617662	118	15038											
RAB34	83871	broad.mit.edu	37	chr17	27042864	27042864	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctcaaatcgttccatctCgaagtccactccaatggtgg	10	10	7	14	2	2	0	1	0	1	0	7	1	5	0	4	2	0	1	4	2	3	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr17:27042864C>A	uc002hce.2	-	4	892	c.268G>T	c.(268-270)GAG>TAG	p.E90*	RAB34_uc002hcg.2_Nonsense_Mutation_p.E90*|RAB34_uc002hcf.2_Nonsense_Mutation_p.E91*|RAB34_uc010was.1_Nonsense_Mutation_p.E147*|RAB34_uc010wat.1_Nonsense_Mutation_p.E147*|RAB34_uc002hch.2_Nonsense_Mutation_p.E90*|RAB34_uc010wau.1_Nonsense_Mutation_p.E68*|RAB34_uc010wav.1_Nonsense_Mutation_p.E148*	NM_031934	NP_114140	Q9BZG1	RAB34_HUMAN	Ras-related protein RAB34 isoform 1	90					protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	Lung NSC(42;0.00431)					CGTTCCATCTCGAAGTCCACT	0.547													29	105					1.80694e-10	1.92277e-10	1	0	A	27042864	A	A	27042864	4	1	73	1	0	0	0	0	0	1	0	0	12989	893	31	3	603	3	RAB34	17	27042864	Nonsense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	19465316	27042864	54152346	119	15039											
GPR179	440435	broad.mit.edu	37	chr17	36483161	36483161	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgcctcagaactgcctctGcttctgtcagaagcatctgg	7	11	10	13	0	5	2	2	0	3	2	5	2	5	2	2	1	5	3	2	1	2	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr17:36483161G>A	uc002hpz.2	-	11	6312	c.6291C>T	c.(6289-6291)AGC>AGT	p.S2097S		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	2097	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AACTGCCTCTGCTTCTGTCAG	0.582													13	73					0	0	0	0	A	36483161	A	A	36483161	2	1	73	1	0	0	0	0	0	0	0	1	6712	1310	46	4		4	GPR179	17	36483161	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08	9440297	36483161	44712049	120	15040											
KCNH6	81033	broad.mit.edu	37	chr17	61621726	61621726	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagacccagattgctggcctCtgaagctgggctccaggcta	9	8	12	12	0	1	3	0	1	1	2	2	3	2	3	3	3	2	4	3	3	3	2			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr17:61621726C>T	uc002jay.2	+	12	2538	c.2458C>T	c.(2458-2460)CTG>TTG	p.L820L	KCNH6_uc010wpl.1_Silent_p.L661L|KCNH6_uc010wpm.1_Silent_p.L784L|KCNH6_uc002jaz.1_Silent_p.L731L	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	820	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	TTGCTGGCCTCTGAAGCTGGG	0.617													9	19					0	0	0	0	T	61621726	T	T	61621726	2	4	73	1	0	0	0	0	0	0	0	1	8075	912	32	2		2	KCNH6	17	61621726	Silent	SNP	C	TCGA-CN-6016-01A-11D-1683-08	25138565	61621726	19573484	121	15041											
DSEL	92126	broad.mit.edu	37	chr18	65179743	65179743	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattgagagaaatctgaagTccaggattggaactatcaat	16	10	9	6	0	2	3	1	2	1	1	3	6	3	5	1	2	1	0	1	2	5	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr18:65179743T>C	uc002lke.1	-	2	3357	c.2133A>G	c.(2131-2133)GGA>GGG	p.G711G		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	701						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				AAATCTGAAGTCCAGGATTGG	0.363													11	45					0	0	0	0	C	65179743	C	C	65179743	2	2	73	1	0	0	0	0	0	0	0	1	4797	1654	58	5		5	DSEL	18	65179743	Silent	SNP	T	TCGA-CN-6016-01A-11D-1683-08		65179743	12897505	122	15042											
ZNF491	126069	broad.mit.edu	37	chr19	11917375	11917375	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcaatttttccagttcctttCgcagacatgaaaggacacac	12	12	6	11	1	1	2	1	1	0	1	4	3	3	3	2	1	0	2	2	1	2	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr19:11917375C>G	uc002mso.1	+	3	892	c.607C>G	c.(607-609)CGC>GGC	p.R203G		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	203	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CAGTTCCTTTCGCAGACATGA	0.438													23	18					0	0	0	0	G	11917375	G	G	11917375	3	3	73	1	0	0	0	0	1	0	0	0	18009	884	31	3	609	3	ZNF491	19	11917375	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08		11917375	47211608	123	15043											
OR10H2	26538	broad.mit.edu	37	chr19	15839214	15839214	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctcaccgtcatgggctacGaccgctacgtggccatctgc	6	9	11	15	4	3	0	2	0	1	0	3	1	3	0	3	2	4	3	3	2	2	2	rs113885700	byFrequency	TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr19:15839214G>A	uc002nbm.2	+	1	381	c.361G>A	c.(361-363)GAC>AAC	p.D121N		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CATGGGCTACGACCGCTACGT	0.652													6	55					0	0	0	0	A	15839214	A	A	15839214	3	1	73	1	0	0	0	0	1	0	0	0	10960	1058	37	1	363	1	OR10H2	19	15839214	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	3921839	15839214	43289769	124	15044											
GPATCH1	55094	broad.mit.edu	37	chr19	33587186	33587186	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacctgtggatttcacacCtaaagataatgtgcatggtc	12	11	8	10	0	1	1	1	0	0	1	2	2	1	2	2	2	1	1	2	2	3	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr19:33587186C>T	uc002nug.1	+	7	1000	c.686C>T	c.(685-687)CCT>CTT	p.P229L		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	229						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					GATTTCACACCTAAAGATAAT	0.438													14	87					0	0	0	0	T	33587186	T	T	33587186	3	4	73	1	0	0	0	0	1	0	0	0	6628	681	24	4	712	4	GPATCH1	19	33587186	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	17747972	33587186	25541797	125	15045											
FCGBP	8857	broad.mit.edu	37	chr19	40420125	40420125	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaacacctgcacctgcccatCtgctgcttggaagggcagat	9	8	11	13	0	1	1	0	0	1	1	1	3	1	2	3	2	5	4	3	2	2	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr19:40420125C>G	uc002omp.3	-	6	2877	c.2869G>C	c.(2869-2871)GAT>CAT	p.D957H		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	957	VWFD 2.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACCTGCCCATCTGCTGCTTGG	0.567													8	45					0	0	0	0	G	40420125	G	G	40420125	3	3	73	1	0	0	0	0	1	0	0	0	5810	913	32	2	13472	2	FCGBP	19	40420125	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	6832939	40420125	18708858	126	15046											
CYP2F1	1572	broad.mit.edu	37	chr19	41622401	41622401	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtacacagtgcacctgggAcccaggcgggtggtggtcct	7	8	15	11	1	0	0	0	0	0	0	1	1	1	1	3	5	2	2	3	5	1	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr19:41622401A>G	uc002opu.1	+	3	269	c.213A>G	c.(211-213)GGA>GGG	p.G71G	CYP2F1_uc010xvw.1_5'UTR|CYP2F1_uc010xvv.1_Silent_p.G71G|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	71					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						TGCACCTGGGACCCAGGCGGG	0.612													5	109					0	0	0	0	G	41622401	G	G	41622401	2	3	73	1	0	0	0	0	0	0	0	1	4188	262	10	5		5	CYP2F1	19	41622401	Silent	SNP	A	TCGA-CN-6016-01A-11D-1683-08	1202276	41622401	17506582	127	15047											
SYMPK	8189	broad.mit.edu	37	chr19	46319207	46319207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgcccggggtctcgcactCaggcccctcctcccggaaat	6	7	11	17	3	2	0	1	0	1	0	5	2	4	1	5	4	1	1	5	4	1	0			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr19:46319207C>T	uc002pdn.2	-	26	3834	c.3589G>A	c.(3589-3591)GAG>AAG	p.E1197K	RSPH6A_uc002pdm.2_5'Flank	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	1197					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GTCTCGCACTCAGGCCCCTCC	0.597													3	16					0	0	0	0	T	46319207	T	T	46319207	3	4	73	1	0	0	0	0	1	0	0	0	15505	835	29	2	243	2	SYMPK	19	46319207	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	4696806	46319207	12809776	128	15048											
CCDC61	729440	broad.mit.edu	37	chr19	46509871	46509871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acacagacctggagtccctgCggaaccgcaagatggggggc	10	4	15	12	2	0	2	0	0	0	2	1	4	1	4	3	5	2	1	3	5	2	0			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr19:46509871C>T	uc002pdw.2	+	5	457	c.457C>T	c.(457-459)CGG>TGG	p.R153W		NM_001080402	NP_001073871			coiled-coil domain containing 61											ovary(1)	1		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		GGAGTCCCTGCGGAACCGCAA	0.632													9	28					0	0	0	0	T	46509871	T	T	46509871	3	4	73	1	0	0	0	0	1	0	0	0	2845	759	27	1	475	1	CCDC61	19	46509871	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	190664	46509871	12619112	129	15049											
ZNF766	90321	broad.mit.edu	37	chr19	52785416	52785416	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attctctcaggaggagtggaAatgcctggaccctgtgcaga	10	9	13	9	0	2	1	1	0	1	1	3	5	2	5	2	4	2	1	2	4	1	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr19:52785416A>T	uc002pyr.1	+	2	114	c.71A>T	c.(70-72)AAA>ATA	p.K24I	ZNF766_uc002pys.1_Missense_Mutation_p.K24I|ZNF766_uc002pyt.1_Missense_Mutation_p.K39I	NM_001010851	NP_001010851	Q5HY98	ZN766_HUMAN	zinc finger protein 766	24	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		GAGGAGTGGAAATGCCTGGAC	0.463													32	152					0	0	0	0	T	52785416	T	T	52785416	3	4	73	1	0	0	0	0	1	0	0	0	18207	14	1	5	77	5	ZNF766	19	52785416	Missense_Mutation	SNP	A	TCGA-CN-6016-01A-11D-1683-08	6275545	52785416	6343567	130	15050											
CNOT3	4849	broad.mit.edu	37	chr19	54653382	54653382	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggacccagcctcctggtGccactgcctgtgaatcctcc	5	8	12	16	0	0	1	0	1	0	0	3	2	3	2	7	3	3	0	7	3	1	0			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr19:54653382G>C	uc002qdj.1	+	13	1805	c.1494G>C	c.(1492-1494)GTG>GTC	p.V498V	CNOT3_uc010yel.1_Silent_p.V498V|CNOT3_uc002qdi.2_Silent_p.V411V|CNOT3_uc002qdk.1_Silent_p.V498V|CNOT3_uc010ere.1_RNA|CNOT3_uc002qdl.2_5'UTR	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	498	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCTCCTGGTGCCACTGCCTG	0.677													5	23					0	0	0	0	C	54653382	C	C	54653382	2	2	73	1	0	0	0	0	0	0	0	1	3635	1306	46	4		4	CNOT3	19	54653382	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08	1867966	54653382	4475601	131	15051											
ZNF211	10520	broad.mit.edu	37	chr19	58146066	58146066	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggatctccttgatgaggctCagaaacacctgtacttcgat	10	11	10	10	1	2	3	1	2	1	1	4	5	2	4	2	2	2	2	2	2	2	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr19:58146066C>G	uc002qpq.2	+	2	340	c.160C>G	c.(160-162)CAG>GAG	p.Q54E	ZNF211_uc010yhb.1_Missense_Mutation_p.Q58E|ZNF211_uc002qpp.2_Missense_Mutation_p.Q67E|ZNF211_uc002qpr.2_Missense_Mutation_p.Q66E|ZNF211_uc002qps.2_Missense_Mutation_p.Q67E|ZNF211_uc002qpt.2_Missense_Mutation_p.Q66E|ZNF211_uc010yhc.1_Missense_Mutation_p.Q66E|ZNF211_uc010yhd.1_5'UTR|ZNF211_uc010yhe.1_5'UTR	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	54	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGATGAGGCTCAGAAACACCT	0.502													12	84					0	0	0	0	G	58146066	G	G	58146066	3	3	73	1	0	0	0	0	1	0	0	0	17834	827	29	2	209	2	ZNF211	19	58146066	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	3492684	58146066	982917	132	15052											
HAO1	54363	broad.mit.edu	37	chr20	7866452	7866452	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcctttccgcacacccccGtccaggaagacttccacctt	7	9	7	18	2	0	1	0	0	0	1	3	2	3	2	7	1	1	1	7	1	1	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr20:7866452G>A	uc002wmw.1	-	6	897	c.873C>T	c.(871-873)GAC>GAT	p.D291D	HAO1_uc010gbu.2_Silent_p.D291D	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	291	FMN binding.|FMN hydroxy acid dehydrogenase.|FMN (By similarity).				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						GCACACCCCCGTCCAGGAAGA	0.502													15	120					0	0	0	0	A	7866452	A	A	7866452	2	1	73	1	0	0	0	0	0	0	0	1	6990	1136	40	1		1	HAO1	20	7866452	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08		7866452	55159068	133	15053											
XRN2	22803	broad.mit.edu	37	chr20	21335499	21335499	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggtatacccagacctcaCtccagaagagagtaagaatt	16	7	9	9	0	1	5	1	0	0	5	2	6	2	5	3	1	1	2	3	1	5	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr20:21335499C>T	uc002wsf.1	+	21	2104	c.2009C>T	c.(2008-2010)ACT>ATT	p.T670I	XRN2_uc002wsg.1_Missense_Mutation_p.T594I|XRN2_uc010zsk.1_Missense_Mutation_p.T616I	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	670					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						CCAGACCTCACTCCAGAAGAG	0.398													3	25					0	0	0	0	T	21335499	T	T	21335499	3	4	73	1	0	0	0	0	1	0	0	0	17528	565	20	4	2091	4	XRN2	20	21335499	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	13469047	21335499	41690021	134	15054											
PFKL	5211	broad.mit.edu	37	chr21	45746680	45746680	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aataccgcatcagtatggccGcctacgtgtcaggggagctg	9	8	13	11	3	2	0	2	0	0	0	2	1	2	1	3	3	3	3	3	3	4	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr21:45746680G>A	uc002zel.2	+	22	2337	c.2278G>A	c.(2278-2280)GCC>ACC	p.A760T	PFKL_uc002zek.2_Missense_Mutation_p.A807T|PFKL_uc002zem.2_Missense_Mutation_p.A347T|PFKL_uc002zen.2_Missense_Mutation_p.A347T	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	760					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		CAGTATGGCCGCCTACGTGTC	0.667													3	9					0	0	0	0	A	45746680	A	A	45746680	3	1	73	1	0	0	0	0	1	0	0	0	11819	1087	38	1	2364	1	PFKL	21	45746680	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08		45746680	2383215	135	15055											
CCT8L2	150160	broad.mit.edu	37	chr22	17072823	17072823	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtgtccccccgggcagcgcGcacaccccaacacgctcagg	8	3	11	19	4	1	0	1	0	0	0	2	0	2	0	5	2	2	3	5	2	1	0	rs137862002		TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr22:17072823G>A	uc002zlp.1	-	1	878	c.618C>T	c.(616-618)TGC>TGT	p.C206C		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	206					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CGGGCAGCGCGCACACCCCAA	0.617													4	83					0	0	0	0	A	17072823	A	A	17072823	2	1	73	1	0	0	0	0	0	0	0	1	2976	1079	38	1		1	CCT8L2	22	17072823	Silent	SNP	G	TCGA-CN-6016-01A-11D-1683-08		17072823	34231743	136	15056											
MYH9	4627	broad.mit.edu	37	chr22	36710351	36710351	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaattgatgcacagctgctCaaacgagttcagctgcaagg	12	9	11	9	1	2	1	2	1	0	0	2	2	2	1	0	1	6	7	0	1	3	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr22:36710351C>G	uc003apg.2	-	13	1624	c.1393G>C	c.(1393-1395)GAG>CAG	p.E465Q	MYH9_uc003aph.1_Missense_Mutation_p.E329Q	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	465	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CACAGCTGCTCAAACGAGTTC	0.547			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				14	32					0	0	0	0	G	36710351	G	G	36710351	3	3	73	1	0	0	0	0	1	0	0	0	10095	835	29	2	4605	2	MYH9	22	36710351	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08	19637528	36710351	14594215	137	15057											
PICK1	9463	broad.mit.edu	37	chr22	38465066	38465066	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaaagtcaagcaccggctgGtggagaacatgagttcaggg	13	6	15	7	1	2	3	2	1	0	2	2	4	2	3	1	4	2	3	1	4	3	1			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chr22:38465066G>A	uc003auq.2	+	6	766	c.376G>A	c.(376-378)GTG>ATG	p.V126M	PICK1_uc003aur.2_Missense_Mutation_p.V126M|PICK1_uc003aus.2_Missense_Mutation_p.V126M|PICK1_uc003aut.2_Missense_Mutation_p.V126M	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	126					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					GCACCGGCTGGTGGAGAACAT	0.632													10	15					0	0	0	0	A	38465066	A	A	38465066	3	1	73	1	0	0	0	0	1	0	0	0	11936	1261	44	4	394	4	PICK1	22	38465066	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	1754715	38465066	12839500	138	15058											
DMD	1756	broad.mit.edu	37	chrX	32613911	32613911	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aagcagcagttgcgtgatctCcactagattcatcaactacc	12	10	7	12	1	3	2	2	1	1	1	4	2	3	2	2	0	5	3	2	0	4	4			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chrX:32613911C>G	uc004dda.1	-	13	1809	c.1565G>C	c.(1564-1566)GGA>GCA	p.G522A	DMD_uc004dcz.2_Missense_Mutation_p.G399A|DMD_uc004dcy.1_Missense_Mutation_p.G518A|DMD_uc004ddb.1_Missense_Mutation_p.G514A|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.G514A|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	522	Spectrin 2.		Missing (in BMD).		muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGCGTGATCTCCACTAGATTC	0.353													7	23					0	0	0	0	G	32613911	G	G	32613911	3	3	73	1	0	0	0	0	1	0	0	0	4602	855	30	2	10003	2	DMD	23	32613911	Missense_Mutation	SNP	C	TCGA-CN-6016-01A-11D-1683-08		32613911	122656649	139	15059											
C1GALT1C1	29071	broad.mit.edu	37	chrX	119760090	119760090	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cattgtcagaaccatttggaGgtaagaaaaccaatgcatca	16	9	8	8	0	2	2	2	0	0	2	2	3	2	3	2	2	3	2	2	2	5	3			TCGA-CN-6016-01A-11D-1683-08	TCGA-CN-6016-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb6e29c-864d-483f-a848-8a61202d9516	06bd7b3a-430d-4d4f-8846-e7997440d241	g.chrX:119760090G>A	uc004esy.2	-	3	1279	c.932C>T	c.(931-933)CCT>CTT	p.P311L	C1GALT1C1_uc004esz.2_Missense_Mutation_p.P311L	NM_152692	NP_689905	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	311	Lumenal (Potential).					integral to membrane					0						ACCATTTGGAGGTAAGAAAAC	0.378													16	34					0	0	0	0	A	119760090	A	A	119760090	3	1	73	1	0	0	0	0	1	0	0	0	1962	1000	35	4	28	4	C1GALT1C1	23	119760090	Missense_Mutation	SNP	G	TCGA-CN-6016-01A-11D-1683-08	87146179	119760090	35510470	140	15060											
MPZ	4359	broad.mit.edu	37	chr1	161279785	161279785	+	5'Flank	DEL	A	-	-																															ggggttcctggaacctgcttAaaatcccctagggccccagc																										TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr1:161279785delA	uc001gaf.3	-						MPZ_uc010pko.1_5'Flank	NM_000530	NP_000521	P25189	MYP0_HUMAN	myelin protein zero						synaptic transmission	integral to plasma membrane	structural molecule activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			GAACCTGCTTAAAATCCCCTA	0.632													---	---	---								-	161279785	-	-	161279785	6	5	74	0	1	1	0	1	0	0	0	0	9801	377	13	0		0	MPZ	1	161279785	5'Flank	DEL	A	TCGA-CN-6017-01A-11D-1683-08		161279785	87970836	1	15061											
NCKAP1	10787	broad.mit.edu	37	chr2	183888621	183888621	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgtcgataagataggatggTtttgccttggggtctccaca	8	14	12	7	1	1	1	0	0	1	1	3	3	1	2	2	4	1	1	2	4	2	6			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr2:183888621T>C	uc002upc.2	-	2	534	c.132A>G	c.(130-132)AAA>AAG	p.K44K	NCKAP1_uc002upb.2_Silent_p.K50K	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	44					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GATAGGATGGTTTTGCCTTGG	0.353													5	109					0	0	0	0	C	183888621	C	C	183888621	2	2	74	1	0	0	0	0	0	0	0	1	10275	1722	60	5		5	NCKAP1	2	183888621	Silent	SNP	T	TCGA-CN-6017-01A-11D-1683-08		183888621	59310752	2	15062											
SLC15A2	6565	broad.mit.edu	37	chr3	121647850	121647850	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaacaccacactattccaaaCtgcacctgaaaacaaaaagc	20	5	3	13	0	0	1	0	1	0	0	1	1	1	1	3	0	5	1	3	0	7	2			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr3:121647850C>G	uc003eep.2	+	16	1516	c.1363C>G	c.(1363-1365)CTG>GTG	p.L455V	SLC15A2_uc011bjn.1_Missense_Mutation_p.L424V	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	455					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CTATTCCAAACTGCACCTGAA	0.403													4	106					0	0	0	0	G	121647850	G	G	121647850	3	3	74	1	0	0	0	0	1	0	0	0	14464	564	20	4	1425	4	SLC15A2	3	121647850	Missense_Mutation	SNP	C	TCGA-CN-6017-01A-11D-1683-08		121647850	76374580	3	15063											
DOCK2	1794	broad.mit.edu	37	chr5	169122871	169122871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgtcaaatagtccgggtcgGcaagatggatcttaaggata	12	11	12	6	2	2	1	1	0	1	1	4	3	3	3	1	4	0	1	1	4	5	4			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr5:169122871G>A	uc003maf.2	+	10	988	c.908G>A	c.(907-909)GGC>GAC	p.G303D	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	303					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCCGGGTCGGCAAGATGGAT	0.463													4	59					0	0	0	0	A	169122871	A	A	169122871	3	1	74	1	0	0	0	0	1	0	0	0	4709	1203	42	4	946	4	DOCK2	5	169122871	Missense_Mutation	SNP	G	TCGA-CN-6017-01A-11D-1683-08		169122871	11792389	4	15064											
OR12D2	26529	broad.mit.edu	37	chr6	29365004	29365004	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccgtatccatcattttctCtgtgatattaagccattgct	10	16	5	10	1	2	1	1	1	1	0	4	1	3	1	3	0	3	2	3	0	4	6			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr6:29365004C>G	uc003nmf.3	+	1	589	c.528C>G	c.(526-528)CTC>CTG	p.L176L		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCATTTTCTCTGTGATATTA	0.483													5	114					0	0	0	0	G	29365004	G	G	29365004	2	3	74	1	0	0	0	0	0	0	0	1	10985	900	32	2		2	OR12D2	6	29365004	Silent	SNP	C	TCGA-CN-6017-01A-11D-1683-08		29365004	141750063	5	15065											
NEDD1	121441	broad.mit.edu	37	chr12	97331069	97331069	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggaggagttcagaattccGgaattgtcagagaagcacct	12	9	13	7	1	2	2	2	0	0	2	3	6	3	5	2	3	1	2	2	3	3	3			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr12:97331069G>A	uc001teu.3	+	9	1354	c.1015G>A	c.(1015-1017)GGA>AGA	p.G339R	NEDD1_uc001tev.3_Missense_Mutation_p.G339R|NEDD1_uc010svc.1_Missense_Mutation_p.G250R|NEDD1_uc001tew.2_Missense_Mutation_p.G346R|NEDD1_uc001tex.2_Missense_Mutation_p.G250R	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	339					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						TCAGAATTCCGGAATTGTCAG	0.428													4	64					0	0	0	0	A	97331069	A	A	97331069	3	1	74	1	0	0	0	0	1	0	0	0	10363	1117	39	1	1066	1	NEDD1	12	97331069	Missense_Mutation	SNP	G	TCGA-CN-6017-01A-11D-1683-08		97331069	36520826	6	15066											
SMG1	23049	broad.mit.edu	37	chr16	18846419	18846419	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcgtatcgctgcagggTcatttcagtggcagtgatga	7	12	14	8	2	2	2	2	2	0	0	3	2	2	2	0	2	3	5	0	2	1	2			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr16:18846419T>G	uc002dfm.2	-	49	8488	c.8125A>C	c.(8125-8127)ACC>CCC	p.T2709P	SMG1_uc010bwb.2_Missense_Mutation_p.T2569P|SMG1_uc010bwa.2_Missense_Mutation_p.T1440P	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2709					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CGCTGCAGGGTCATTTCAGTG	0.443													4	121					0	0	0	0	G	18846419	G	G	18846419	3	3	74	1	0	0	0	0	1	0	0	0	14859	1667	58	5	2920	5	SMG1	16	18846419	Missense_Mutation	SNP	T	TCGA-CN-6017-01A-11D-1683-08		18846419	71508334	7	15067											
TP53	7157	broad.mit.edu	37	chr17	7579441	7579453	+	Frame_Shift_Del	DEL	CGGTGTAGGAGCT	-	-																															ggggctggtgcaggggccgcCggtgtaggagctgctggtgc																										TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr17:7579441_7579453delCGGTGTAGGAGCT	uc002gim.2	-	4	428_440	c.234_246delAGCTCCTACACCG	c.(232-246)GCAGCTCCTACACCGfs	p.A78fs	TP53_uc002gig.1_Frame_Shift_Del_p.A78fs|TP53_uc002gih.2_Frame_Shift_Del_p.A78fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.A78fs|TP53_uc010cni.1_Frame_Shift_Del_p.A78fs|TP53_uc002gij.2_Frame_Shift_Del_p.A78fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.A39fs|TP53_uc010cnk.1_Frame_Shift_Del_p.A93fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	78_82	Interaction with WWOX.|Interaction with HRMT1L2.		P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.P82L(5)|p.A76_S90del15(3)|p.G59fs*23(3)|p.T81I(2)|p.A78V(2)|p.V73fs*9(1)|p.R65fs*38(1)|p.D48fs*55(1)|p.P80L(1)|p.A79V(1)|p.A79_A88del10(1)|p.P82fs*43(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.P82fs*67(1)|p.P80fs*41(1)|p.P82P(1)|p.P80fs*43(1)|p.A83fs*91(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGGCCGCCGGTGTAGGAGCTGCTGGTGCAG	0.61		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7579453	-	-	7579441	7	5	74	1	0	1	0	1	0	0	0	0	16448	639	23	0	1056	0	TP53	17	7579441	Frame_Shift_Del	DEL	CGGTGTAGGAGCT	TCGA-CN-6017-01A-11D-1683-08		7579441	73615769	8	15068											
OR7G2	390882	broad.mit.edu	37	chr19	9213904	9213904	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaattttgaaatagctgtttGgtttctcgcttccatgctgt	7	18	9	7	1	1	1	0	1	1	0	3	2	2	1	1	1	2	5	1	1	3	6			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr19:9213904G>T	uc010xkk.1	-	1	79	c.79C>A	c.(79-81)CAA>AAA	p.Q27K		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATAGCTGTTTGGTTTCTCGCT	0.358													3	59					6.4e-05	6.98182e-05	1	0	T	9213904	T	T	9213904	3	4	74	1	0	0	0	0	1	0	0	0	11277	1357	47	4	960	4	OR7G2	19	9213904	Missense_Mutation	SNP	G	TCGA-CN-6017-01A-11D-1683-08		9213904	49915079	9	15069											
PGD	5226	broad.mit.edu	37	chr1	10477152	10477152	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttgatggtgataagaaatCattcctggaggacattcgga	12	12	12	5	1	1	3	1	2	0	1	3	6	2	6	1	4	0	1	1	4	2	4			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:10477152C>G	uc001arc.2	+	9	1043	c.953C>G	c.(952-954)TCA>TGA	p.S318*	PGD_uc001ard.2_Nonsense_Mutation_p.S238*|PGD_uc010oak.1_Nonsense_Mutation_p.S296*|PGD_uc010oal.1_Nonsense_Mutation_p.S305*	NM_002631	NP_002622	P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	318					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		GATAAGAAATCATTCCTGGAG	0.517													12	57					0	0	0	0	G	10477152	G	G	10477152	4	3	75	1	0	0	0	0	0	1	0	0	11842	838	29	2	987	2	PGD	1	10477152	Nonsense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08		10477152	238773469	1	15070											
GJA9	81025	broad.mit.edu	37	chr1	39340697	39340697	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccattaagttcttttccAaatattttatgagtgtcttt	10	21	4	6	0	2	1	0	1	2	0	3	1	3	1	2	0	1	1	2	0	5	9			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:39340697A>C	uc001cct.1	-	2	1355	c.1074T>G	c.(1072-1074)TTT>TTG	p.F358L	RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399	P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	358	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			GTTCTTTTCCAAATATTTTAT	0.343													8	40					0	0	0	0	C	39340697	C	C	39340697	3	2	75	1	0	0	0	0	1	0	0	0	6443	127	5	5	477	5	GJA9	1	39340697	Missense_Mutation	SNP	A	TCGA-CN-6018-01A-11D-1683-08	28863545	39340697	209909924	2	15071											
PABPC4	8761	broad.mit.edu	37	chr1	40034595	40034595	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taccacttatttcttttccaTtcatctcttccacagcctag	8	17	2	14	0	3	0	1	0	2	0	6	0	5	0	4	0	2	0	4	0	3	8			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:40034595T>C	uc010oiv.1	-	6	1653	c.755A>G	c.(754-756)AAT>AGT	p.N252S	PABPC4_uc001cdl.2_Missense_Mutation_p.N252S|PABPC4_uc001cdm.2_Missense_Mutation_p.N252S|SNORA55_uc001cdo.1_5'Flank	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	252	RRM 3.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TTCTTTTCCATTCATCTCTTC	0.368													19	85					0	0	0	0	C	40034595	C	C	40034595	3	2	75	1	0	0	0	0	1	0	0	0	11420	1493	52	5	1267	5	PABPC4	1	40034595	Missense_Mutation	SNP	T	TCGA-CN-6018-01A-11D-1683-08	693898	40034595	209216026	3	15072											
EPHX4	253152	broad.mit.edu	37	chr1	92495738	92495738	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcgggctctgcgcctccatCcacctgctcaaacttttgtg	5	12	9	15	2	2	0	1	0	1	0	4	0	4	0	4	1	4	2	4	1	1	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:92495738C>T	uc001don.2	+	1	206	c.102C>T	c.(100-102)ATC>ATT	p.I34I		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	34	Helical; Signal-anchor for type II membrane protein; (Potential).					integral to membrane	hydrolase activity			central_nervous_system(1)	1						GCGCCTCCATCCACCTGCTCA	0.697													4	4					0	0	0	0	T	92495738	T	T	92495738	2	4	75	1	0	0	0	0	0	0	0	1	5206	845	30	2		2	EPHX4	1	92495738	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	52461143	92495738	156754883	4	15073											
NOTCH2	4853	broad.mit.edu	37	chr1	120466368	120466368	+	Frame_Shift_Del	DEL	T	-	-																															ggtacaccatgagttcccccTgggagtcccgcttaatgcgc																										TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:120466368delT	uc001eik.2	-	26	5007	c.4751delA	c.(4750-4752)CAGfs	p.Q1584fs		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1584	Negative regulatory region (NRR).|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity	p.Q1584*(1)		lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGTTCCCCCTGGGAGTCCCG	0.542			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				---	---	---								-	120466368	-	-	120466368	7	5	75	1	0	1	0	1	0	0	0	0	10602	1580	55	0	2700	0	NOTCH2	1	120466368	Frame_Shift_Del	DEL	T	TCGA-CN-6018-01A-11D-1683-08	27970630	120466368	128784253	5	15074											
MRPL9	65005	broad.mit.edu	37	chr1	151735515	151735515	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggttttctttgggccgatgCttcgtgtcctccaccagctt	4	15	10	12	2	1	0	0	0	1	0	4	1	3	0	4	2	2	3	4	2	0	5	rs148707904		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:151735515C>T	uc001eyv.2	-	2	346	c.261G>A	c.(259-261)AAG>AAA	p.K87K	MRPL9_uc009wmz.2_RNA|MRPL9_uc010pdk.1_Silent_p.K87K|MRPL9_uc009wna.1_Silent_p.K87K	NM_031420	NP_113608	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9 precursor	87					translation	mitochondrial ribosome	structural constituent of ribosome			ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGGGCCGATGCTTCGTGTCCT	0.647													40	57					0	0	0	0	T	151735515	T	T	151735515	2	4	75	1	0	0	0	0	0	0	0	1	9873	796	28	4		4	MRPL9	1	151735515	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	31269147	151735515	97515106	6	15075											
IGSF8	93185	broad.mit.edu	37	chr1	160061631	160061631	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcaccgttttcgaagcctCttcatgaagcagcaagtgat	11	11	9	10	2	3	2	2	2	1	0	4	4	3	2	2	0	3	3	2	0	3	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:160061631C>A	uc001fva.2	-	6	1869	c.1824G>T	c.(1822-1824)AAG>AAT	p.K608N	IGSF8_uc001fuz.2_Missense_Mutation_p.K608N|IGSF8_uc009wtf.2_Missense_Mutation_p.K608N	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	608	Cytoplasmic (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TTCGAAGCCTCTTCATGAAGC	0.557													3	56					0.00909568	0.00955046	1	0	A	160061631	A	A	160061631	3	1	75	1	0	0	0	0	1	0	0	0	7643	912	32	2	21	2	IGSF8	1	160061631	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	8326116	160061631	89188990	7	15076											
ZNF670	93474	broad.mit.edu	37	chr1	247201259	247201259	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tacatgcatagggtttctctCcagtatgagttctttcatgt	8	17	8	8	0	3	1	1	1	2	0	5	1	4	1	1	1	2	4	1	1	3	6			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr1:247201259C>G	uc001icd.1	-	4	833	c.662G>C	c.(661-663)GGA>GCA	p.G221A	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			GGGTTTCTCTCCAGTATGAGT	0.358													7	20					0	0	0	0	G	247201259	G	G	247201259	3	3	75	1	0	0	0	0	1	0	0	0	18144	855	30	2	511	2	ZNF670	1	247201259	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	87139628	247201259	2049362	8	15077											
BCL11A	53335	broad.mit.edu	37	chr2	60688817	60688817	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcctgggtgcacgcgtggtcGcacaggttgcacttgtaggg	5	9	17	10	3	0	0	0	0	0	0	1	0	0	0	1	4	2	5	1	4	1	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:60688817G>A	uc002sae.1	-	4	1458	c.1230C>T	c.(1228-1230)TGC>TGT	p.C410C	BCL11A_uc002sab.2_Silent_p.C410C|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Silent_p.C79C|BCL11A_uc010ypj.1_Silent_p.C376C|BCL11A_uc002sad.1_Silent_p.C258C|BCL11A_uc002saf.1_Silent_p.C376C	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	410	C2H2-type 3.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ACGCGTGGTCGCACAGGTTGC	0.597			T	IGH@	B-CLL								18	84					0	0	0	0	A	60688817	A	A	60688817	2	1	75	1	0	0	0	0	0	0	0	1	1365	1079	38	1		1	BCL11A	2	60688817	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08		60688817	182510556	9	15078											
DUSP11	8446	broad.mit.edu	37	chr2	73993700	73993700	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttcaaaatcacttgacctGggtacactggaattccaatt	12	13	6	10	0	3	1	2	1	1	0	4	2	4	2	2	2	1	1	2	2	5	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:73993700G>C	uc002sjp.2	-	8	822	c.780C>G	c.(778-780)CCC>CCG	p.P260P		NM_003584	NP_003575	O75319	DUS11_HUMAN	dual specificity phosphatase 11	213					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			skin(1)	1						CACTTGACCTGGGTACACTGG	0.373													6	76					0	0	0	0	C	73993700	C	C	73993700	2	2	75	1	0	0	0	0	0	0	0	1	4833	1335	47	4		4	DUSP11	2	73993700	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	13304883	73993700	169205673	10	15079											
ZNF2	7549	broad.mit.edu	37	chr2	95846873	95846873	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaactaagcctgagattcaCgatgcttcagacaaaaaatc	17	8	7	9	1	2	2	2	1	0	2	3	5	2	2	1	0	3	1	1	0	5	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:95846873C>T	uc002suf.2	+	5	762	c.300C>T	c.(298-300)CAC>CAT	p.H100H	ZNF2_uc002sug.2_Silent_p.H58H|ZNF2_uc010yue.1_Silent_p.H62H|ZNF2_uc010fhs.2_Silent_p.H20H	NM_021088	NP_066574	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2 isoform a	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		CTGAGATTCACGATGCTTCAG	0.423													13	68					0	0	0	0	T	95846873	T	T	95846873	2	4	75	1	0	0	0	0	0	0	0	1	17827	535	19	1		1	ZNF2	2	95846873	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	21853173	95846873	147352500	11	15080											
LONRF2	164832	broad.mit.edu	37	chr2	100919411	100919411	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttctttcttcacagagttaCattcaggattcagagcaagg	11	13	8	9	0	5	2	3	0	2	2	5	3	5	3	0	2	2	2	0	2	2	6			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:100919411C>T	uc002tal.3	-	3	1533	c.893G>A	c.(892-894)TGT>TAT	p.C298Y	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	298	TPR 5.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						CACAGAGTTACATTCAGGATT	0.403													26	65					0	0	0	0	T	100919411	T	T	100919411	3	4	75	1	0	0	0	0	1	0	0	0	8945	478	17	4	1411	4	LONRF2	2	100919411	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	5072538	100919411	142279962	12	15081											
DPP10	57628	broad.mit.edu	37	chr2	116485494	116485494	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaataatttttaatgggattGctgactggttatatgaaggt	13	16	10	2	0	0	2	0	2	0	0	0	3	0	3	0	3	1	2	0	3	6	7			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:116485494G>C	uc002tla.1	+	8	1136	c.679G>C	c.(679-681)GCT>CCT	p.A227P	DPP10_uc002tlb.1_Missense_Mutation_p.A177P|DPP10_uc002tlc.1_Missense_Mutation_p.A223P|DPP10_uc002tle.2_Missense_Mutation_p.A231P|DPP10_uc002tlf.1_Missense_Mutation_p.A220P	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	227	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TAATGGGATTGCTGACTGGTT	0.284													4	36					0	0	0	0	C	116485494	C	C	116485494	3	2	75	1	0	0	0	0	1	0	0	0	4749	1319	46	4	880	4	DPP10	2	116485494	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	15566083	116485494	126713879	13	15082											
NCL	4691	broad.mit.edu	37	chr2	232323778	232323778	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaaagactttcaaaccagTgagttccaacgctttctcca	12	10	6	13	1	2	2	1	1	1	1	4	2	3	2	4	0	2	2	4	0	3	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:232323778T>C	uc002vru.2	-	7	1240	c.1099A>G	c.(1099-1101)ACT>GCT	p.T367A	SNORD20_uc002vrw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	367	RRM 1.				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		TTCAAACCAGTGAGTTCCAAC	0.378													29	46					0	0	0	0	C	232323778	C	C	232323778	3	2	75	1	0	0	0	0	1	0	0	0	10280	1696	59	5	1065	5	NCL	2	232323778	Missense_Mutation	SNP	T	TCGA-CN-6018-01A-11D-1683-08	115838284	232323778	10875595	14	15083											
LRRFIP1	9208	broad.mit.edu	37	chr2	238671551	238671551	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtcatgggtgcaccagatGacaggaccagaactcccctt	11	7	11	12	0	1	3	1	1	0	2	2	4	2	4	4	3	2	1	4	3	1	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr2:238671551G>A	uc002vxe.2	+	11	1487	c.1195G>A	c.(1195-1197)GAC>AAC	p.D399N	LRRFIP1_uc002vxc.2_Intron|LRRFIP1_uc010znm.1_Intron|LRRFIP1_uc002vxd.2_Missense_Mutation_p.D375N|LRRFIP1_uc002vxf.2_Missense_Mutation_p.D343N	NM_001137552	NP_001131024	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting	399					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			breast(3)	3		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		TGCACCAGATGACAGGACCAG	0.493													8	68					0	0	0	0	A	238671551	A	A	238671551	3	1	75	1	0	0	0	0	1	0	0	0	9077	1290	45	2	1913	2	LRRFIP1	2	238671551	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	6347773	238671551	4527822	15	15084											
GRM7	2917	broad.mit.edu	37	chr3	6903381	6903381	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcccaacgtgacgctgggCgcgcggatcctggacacttg	6	7	14	14	5	0	1	0	1	0	0	1	3	1	3	2	3	2	1	2	3	1	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:6903381C>T	uc003bqm.2	+	1	580	c.306C>T	c.(304-306)GGC>GGT	p.G102G	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.G102G|GRM7_uc003bql.2_Silent_p.G102G	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	102	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TGACGCTGGGCGCGCGGATCC	0.587													4	15					0	0	0	0	T	6903381	T	T	6903381	2	4	75	1	0	0	0	0	0	0	0	1	6841	755	27	1		1	GRM7	3	6903381	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08		6903381	191119049	16	15085											
EXOSC7	23016	broad.mit.edu	37	chr3	45052755	45052755	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgtgggcaaggtactgcAtgcctccttgcagagtgttg	6	11	15	9	1	0	1	0	0	0	1	1	1	1	1	2	2	4	5	2	2	2	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:45052755A>T	uc003coi.2	+	8	829	c.800A>T	c.(799-801)CAT>CTT	p.H267L	EXOSC7_uc003coh.1_Missense_Mutation_p.H202L|EXOSC7_uc010his.1_Missense_Mutation_p.H186L|EXOSC7_uc003coj.2_Missense_Mutation_p.H267L	NM_015004	NP_055819	Q15024	EXOS7_HUMAN	exosome component 7	267					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		AAGGTACTGCATGCCTCCTTG	0.532													3	11					0	0	0	0	T	45052755	T	T	45052755	3	4	75	1	0	0	0	0	1	0	0	0	5344	217	8	5	830	5	EXOSC7	3	45052755	Missense_Mutation	SNP	A	TCGA-CN-6018-01A-11D-1683-08	38149374	45052755	152969675	17	15086											
LOC646498	646498	broad.mit.edu	37	chr3	49215451	49215451	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggcgctccaggtccttcCgccttccgattccctgcagc	5	9	9	18	3	0	0	0	0	0	0	5	1	5	0	6	2	2	2	6	2	0	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:49215451C>T	uc011bcj.1	-	3	239	c.233G>A	c.(232-234)CGG>CAG	p.R78Q		NM_001080528	NP_001073997			hypothetical LOC646498												0				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.00221)|KIRC - Kidney renal clear cell carcinoma(197;0.00247)		CAGGTCCTTCCGCCTTCCGAT	0.627													5	25					0	0	0	0	T	49215451	T	T	49215451	3	4	75	1	0	0	0	0	1	0	0	0	8934	652	23	1	384	1	LOC646498	3	49215451	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	4162696	49215451	148806979	18	15087											
SI	6476	broad.mit.edu	37	chr3	164767620	164767620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcaatttgtttacattacatCcttttgttgaaccttgaata	11	19	4	7	0	1	2	1	2	0	0	2	2	2	2	2	0	3	2	2	0	6	9			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:164767620C>T	uc003fei.2	-	14	1618	c.1556G>A	c.(1555-1557)GGA>GAA	p.G519E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	519	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TACATTACATCCTTTTGTTGA	0.284										HNSCC(35;0.089)			8	52					0	0	0	0	T	164767620	T	T	164767620	3	4	75	1	0	0	0	0	1	0	0	0	14362	855	30	2	4067	2	SI	3	164767620	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	115552169	164767620	33254810	19	15088											
LRRC31	79782	broad.mit.edu	37	chr3	169557902	169557902	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgatctgaggaagcttggtCacagcatataacaagtgtct	12	11	11	7	0	3	2	1	2	2	0	3	3	3	3	0	2	3	2	0	2	4	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:169557902C>G	uc003fgc.1	-	9	1604	c.1527G>C	c.(1525-1527)GTG>GTC	p.V509V	LRRC31_uc010hwp.1_Silent_p.V453V	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	509										ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			GAAGCTTGGTCACAGCATATA	0.413													13	85					0	0	0	0	G	169557902	G	G	169557902	2	3	75	1	0	0	0	0	0	0	0	1	9036	813	29	2		2	LRRC31	3	169557902	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	4790282	169557902	28464528	20	15089											
CLCN2	1181	broad.mit.edu	37	chr3	184074822	184074822	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggttttctgcttccgcatCacctggacaatcttccggtt	6	15	8	12	2	3	0	1	0	2	0	5	1	5	1	3	3	1	4	3	3	1	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:184074822C>T	uc003foi.2	-	10	1168	c.1044G>A	c.(1042-1044)GTG>GTA	p.V348V	CLCN2_uc003foh.2_5'UTR|CLCN2_uc010hya.1_Silent_p.V348V|CLCN2_uc011brl.1_Silent_p.V348V|CLCN2_uc011brm.1_Silent_p.V304V|CLCN2_uc011brn.1_Silent_p.V348V	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	348	Helical; (By similarity).					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	GCTTCCGCATCACCTGGACAA	0.522													7	27					0	0	0	0	T	184074822	T	T	184074822	2	4	75	1	0	0	0	0	0	0	0	1	3478	813	29	2		2	CLCN2	3	184074822	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	14516920	184074822	13947608	21	15090											
MFI2	4241	broad.mit.edu	37	chr3	196735818	196735818	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcacgggcacgcagctggcaTtgaagaactcgctcactgct	9	8	11	13	3	2	2	2	1	0	1	3	2	2	2	0	2	3	6	0	2	2	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr3:196735818T>C	uc003fxk.3	-	12	1657	c.1544A>G	c.(1543-1545)AAT>AGT	p.N515S		NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	515	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GCAGCTGGCATTGAAGAACTC	0.642													48	75					0	0	0	0	C	196735818	C	C	196735818	3	2	75	1	0	0	0	0	1	0	0	0	9575	1493	52	5	692	5	MFI2	3	196735818	Missense_Mutation	SNP	T	TCGA-CN-6018-01A-11D-1683-08	12660996	196735818	1286612	22	15091											
ZBTB49	166793	broad.mit.edu	37	chr4	4301683	4301683	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atggttgagcatggaccctgTtgctacccacagctgccatc	8	10	10	13	0	0	1	0	1	0	0	1	2	0	2	3	2	5	5	3	2	1	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:4301683T>C	uc003ghu.2	+	2	186	c.11T>C	c.(10-12)GTT>GCT	p.V4A	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_5'Flank	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						ATGGACCCTGTTGCTACCCAC	0.463													11	72					0	0	0	0	C	4301683	C	C	4301683	3	2	75	1	0	0	0	0	1	0	0	0	17617	1725	60	5	13	5	ZBTB49	4	4301683	Missense_Mutation	SNP	T	TCGA-CN-6018-01A-11D-1683-08		4301683	186852593	23	15092											
UGT2A3	79799	broad.mit.edu	37	chr4	69795796	69795796	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaattcttgataatctcataGcattctctttataactggaa	13	16	5	7	0	3	1	1	1	3	0	5	3	3	2	0	1	2	1	0	1	6	8			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:69795796G>T	uc003hef.2	-	6	1350	c.1319C>A	c.(1318-1320)GCT>GAT	p.A440D	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	440	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TAATCTCATAGCATTCTCTTT	0.383													8	48					0.000157383	0.000168871	1	0	T	69795796	T	T	69795796	3	4	75	1	0	0	0	0	1	0	0	0	17023	971	34	4	268	4	UGT2A3	4	69795796	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	65494113	69795796	121358480	24	15093											
ANKRD56	345079	broad.mit.edu	37	chr4	77818042	77818042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgcggatagggccctgatCacgggcctcgggcacctgcg	5	5	17	14	5	1	1	1	1	0	0	2	2	1	2	3	5	1	1	3	5	1	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:77818042C>T	uc003hki.2	-	1	961	c.961G>A	c.(961-963)GAT>AAT	p.D321N		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	321											0						GGGCCCTGATCACGGGCCTCG	0.672													6	19					0	0	0	0	T	77818042	T	T	77818042	3	4	75	1	0	0	0	0	1	0	0	0	682	826	29	2	1424	2	ANKRD56	4	77818042	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	8022246	77818042	113336234	25	15094											
GK2	2712	broad.mit.edu	37	chr4	80328687	80328687	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaggtccattggaatttcaAaaaagtcacagagctcttta	15	11	8	7	0	3	1	2	0	1	1	4	3	4	2	1	2	1	1	1	2	6	4			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:80328687A>G	uc003hlu.2	-	1	686	c.668T>C	c.(667-669)TTT>TCT	p.F223S		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	223					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						TGGAATTTCAAAAAAGTCACA	0.398													16	70					0	0	0	0	G	80328687	G	G	80328687	3	3	75	1	0	0	0	0	1	0	0	0	6458	14	1	5	997	5	GK2	4	80328687	Missense_Mutation	SNP	A	TCGA-CN-6018-01A-11D-1683-08	2510645	80328687	110825589	26	15095											
GPRIN3	285513	broad.mit.edu	37	chr4	90170269	90170270	+	In_Frame_Ins	INS	-	CTG	CTG																															tggggctggtggagacggatINSctgctctcgacactcgccac																										TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:90170269_90170270insCTG	uc003hsm.1	-	2	1511_1512	c.992_993insCAG	c.(991-993)AGA>AGCAGA	p.330_331insS		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	330_331										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		TGGAGACGGATCTGCTCTCGAC	0.545													---	---	---								CTG	90170270	CTG	CTG	90170269	7	5	75	1	0	1	1	0	0	0	0	0	6770	1432	50	0	1341	0	GPRIN3	4	90170269	In_Frame_Ins	INS	-	TCGA-CN-6018-01A-11D-1683-08	9841582	90170269	100984007	27	15096											
PDHA2	5161	broad.mit.edu	37	chr4	96762253	96762253	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagggatcctataataattCtccaagatagaatggtaaac	17	10	8	6	0	1	3	0	0	1	3	3	4	2	4	2	2	1	1	2	2	8	6			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:96762253C>G	uc003htr.3	+	1	1015	c.952C>G	c.(952-954)CTC>GTC	p.L318V		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	318					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TATAATAATTCTCCAAGATAG	0.423													11	42					0	0	0	0	G	96762253	G	G	96762253	3	3	75	1	0	0	0	0	1	0	0	0	11719	913	32	2	954	2	PDHA2	4	96762253	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	6591984	96762253	94392023	28	15097											
METAP1	23173	broad.mit.edu	37	chr4	99982433	99982433	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatcctaacccggcgacttGacagtgcacggcctcacttc	10	8	8	15	3	1	1	1	1	0	0	3	2	2	1	3	2	2	1	3	2	2	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:99982433G>C	uc003huf.3	+	11	1243	c.1126G>C	c.(1126-1128)GAC>CAC	p.D376H	METAP1_uc003hug.2_RNA|METAP1_uc010ild.2_RNA	NM_015143	NP_055958	P53582	AMPM1_HUMAN	methionyl aminopeptidase 1	376					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis|regulation of translation	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(123;3.12e-07)		CCGGCGACTTGACAGTGCACG	0.488													6	54					0	0	0	0	C	99982433	C	C	99982433	3	2	75	1	0	0	0	0	1	0	0	0	9539	1290	45	2	1168	2	METAP1	4	99982433	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	3220180	99982433	91171843	29	15098											
ADH1B	125	broad.mit.edu	37	chr4	100237412	100237413	+	Frame_Shift_Del	DEL	CT	-	-																															gctctccgggtttttacaaaCtctgcattttccacactgag																										TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:100237412_100237413delCT	uc003hus.3	-	4	390_391	c.306_307delAG	c.(304-309)AGAGTTfs	p.R102fs	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Frame_Shift_Del_p.R62fs|ADH1B_uc011ceh.1_Splice_Site_p.M3_splice|ADH1B_uc011cei.1_Frame_Shift_Del_p.R62fs	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	102_103					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	TTTTTACAAACTCTGCATTTTC	0.386													---	---	---								-	100237413	-	-	100237412	7	5	75	1	0	1	0	1	0	0	0	0	308	565	20	0	844	0	ADH1B	4	100237412	Frame_Shift_Del	DEL	CT	TCGA-CN-6018-01A-11D-1683-08	254979	100237412	90916864	30	15099											
FAT4	79633	broad.mit.edu	37	chr4	126239489	126239489	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatcctgtgtctgggaggttGagtactatttcctccttgga	6	15	12	8	0	1	1	0	1	1	0	4	4	4	3	3	3	1	2	3	3	2	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:126239489G>A	uc003ifj.3	+	1	1923	c.1923G>A	c.(1921-1923)TTG>TTA	p.L641L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	641	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGGGAGGTTGAGTACTATTT	0.567													7	25					0	0	0	0	A	126239489	A	A	126239489	2	1	75	1	0	0	0	0	0	0	0	1	5724	1281	45	2		2	FAT4	4	126239489	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	26002077	126239489	64914787	31	15100											
FAT1	2195	broad.mit.edu	37	chr4	187630504	187630504	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccttatagctgtgttttCaggtaaagaaacgctgtatg	10	14	11	6	1	1	1	1	0	0	1	2	1	2	1	1	2	2	5	1	2	6	6			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr4:187630504C>A	uc003izf.2	-	2	666	c.478G>T	c.(478-480)GAA>TAA	p.E160*	FAT1_uc010iso.1_Nonsense_Mutation_p.E160*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	160	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCTGTGTTTTCAGGTAAAGAA	0.463										HNSCC(5;0.00058)			24	137					7.87624e-14	8.83823e-14	1	0	A	187630504	A	A	187630504	4	1	75	1	0	0	0	0	0	1	0	0	5721	835	29	2	13392	2	FAT1	4	187630504	Nonsense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	61391015	187630504	3523772	32	15101											
COL4A3BP	10087	broad.mit.edu	37	chr5	74801835	74801835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagccttgctaagacagatgGatcctctgcagccatactct	10	10	8	13	0	2	2	0	0	2	2	3	3	3	3	3	1	5	2	3	1	2	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr5:74801835G>A	uc011csu.1	-	2	625	c.203C>T	c.(202-204)TCC>TTC	p.S68F	COL4A3BP_uc003kds.2_Missense_Mutation_p.S68F|COL4A3BP_uc003kdt.2_Missense_Mutation_p.S196F|COL4A3BP_uc003kdu.2_Missense_Mutation_p.S68F	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	68	PH.				ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		AAGACAGATGGATCCTCTGCA	0.299													6	67					0	0	0	0	A	74801835	A	A	74801835	3	1	75	1	0	0	0	0	1	0	0	0	3707	1174	41	2	1735	2	COL4A3BP	5	74801835	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08		74801835	106113425	33	15102											
VCAN	1462	broad.mit.edu	37	chr5	82834287	82834287	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggggttcaggaagggctgaCcactctcccacgtagtcctg	7	9	13	12	1	2	1	1	1	1	0	4	2	3	2	3	4	0	3	3	4	2	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr5:82834287C>T	uc003kii.3	+	8	5821	c.5465C>T	c.(5464-5466)ACC>ATC	p.T1822I	VCAN_uc003kij.3_Missense_Mutation_p.T835I|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.T486I	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1822	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GAAGGGCTGACCACTCTCCCA	0.488													37	59					0	0	0	0	T	82834287	T	T	82834287	3	4	75	1	0	0	0	0	1	0	0	0	17206	507	18	4	5491	4	VCAN	5	82834287	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	8032452	82834287	98080973	34	15103											
PDGFRB	5159	broad.mit.edu	37	chr5	149512334	149512334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtctccgacacgttgcgcGtggacagggcgatttcgcca	6	8	15	12	6	1	0	0	0	1	0	3	3	1	1	2	3	1	1	2	3	0	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr5:149512334G>A	uc003lro.2	-	7	1575	c.1106C>T	c.(1105-1107)ACG>ATG	p.T369M	PDGFRB_uc010jhd.2_Missense_Mutation_p.T208M|PDGFRB_uc011dcg.1_3'UTR	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	369	Ig-like C2-type 4.|Extracellular (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CACGTTGCGCGTGGACAGGGC	0.612			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								4	20					0	0	0	0	A	149512334	A	A	149512334	3	1	75	1	0	0	0	0	1	0	0	0	11716	1145	40	1	2282	1	PDGFRB	5	149512334	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	66678047	149512334	31402926	35	15104											
ATP10B	23120	broad.mit.edu	37	chr5	159992867	159992867	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctgagcttttgagattaGagacttcccacaagttcctt	9	16	7	9	0	1	3	0	2	1	2	3	5	3	3	2	0	1	2	2	0	2	7			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr5:159992867G>C	uc003lym.1	-	26	4826	c.3979C>G	c.(3979-3981)CTA>GTA	p.L1327V	ATP10B_uc010jit.1_Missense_Mutation_p.L577V	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1327	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTTGAGATTAGAGACTTCCCA	0.443													16	111					0	0	0	0	C	159992867	C	C	159992867	3	2	75	1	0	0	0	0	1	0	0	0	1119	933	33	2	410	2	ATP10B	5	159992867	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	10480533	159992867	20922393	36	15105											
RANBP17	64901	broad.mit.edu	37	chr5	170336684	170336684	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttgattattctagaccttCagcaaaacacaggaaaatag	16	10	8	7	0	2	2	1	1	1	1	2	3	2	3	1	2	2	2	1	2	7	6			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr5:170336684C>T	uc003mba.2	+	6	525	c.509C>T	c.(508-510)TCA>TTA	p.S170L	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_RNA|RANBP17_uc003maw.2_Missense_Mutation_p.S170L|RANBP17_uc011dew.1_Missense_Mutation_p.S170L	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	170					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTAGACCTTCAGCAAAACAC	0.289			T	TRD@	ALL								4	32					0	0	0	0	T	170336684	T	T	170336684	3	4	75	1	0	0	0	0	1	0	0	0	13092	838	29	2	531	2	RANBP17	5	170336684	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	10343817	170336684	10578576	37	15106											
HIST1H1B	3009	broad.mit.edu	37	chr6	27835120	27835130	+	Frame_Shift_Del	DEL	GCCAAAGAAAG	-	-																															ctaaggccttcttaagggctGccaaagaaaggccattgcgc																										TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:27835120_27835130delGCCAAAGAAAG	uc003njx.2	-	1	230_240	c.178_188delCTTTCTTTGGC	c.(178-189)CTTTCTTTGGCAfs	p.L60fs		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	60_63	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CTTAAGGGCTGCCAAAGAAAGGCCATTGCGC	0.611													---	---	---								-	27835130	-	-	27835120	7	5	75	1	0	1	0	1	0	0	0	0	7162	1319	46	0	496	0	HIST1H1B	6	27835120	Frame_Shift_Del	DEL	GCCAAAGAAAG	TCGA-CN-6018-01A-11D-1683-08		27835120	143279947	38	15107											
OR2J3	442186	broad.mit.edu	37	chr6	29080240	29080240	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcacttctgcgattatcGtgtgttgatacccatgtcaa	9	13	8	11	2	2	1	1	1	1	0	3	2	2	1	2	0	3	2	2	0	3	4	rs138982330	by1000genomes	TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:29080240G>A	uc011dll.1	+	1	573	c.573G>A	c.(571-573)TCG>TCA	p.S191S		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCGATTATCGTGTGTTGATA	0.463													19	49					0	0	0	0	A	29080240	A	A	29080240	2	1	75	1	0	0	0	0	0	0	0	1	11058	1132	40	1		1	OR2J3	6	29080240	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	1245120	29080240	142034827	39	15108											
PIM1	5292	broad.mit.edu	37	chr6	37140900	37140900	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atattcctttcgagcatgacGaagagatcatcaggggccag	12	9	11	9	2	2	2	2	1	0	1	4	5	3	2	2	2	1	1	2	2	2	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:37140900G>A	uc003onk.2	+	5	1166	c.736G>A	c.(736-738)GAA>AAA	p.E246K	PIM1_uc011dtw.1_Silent_p.T114T	NM_002648	NP_002639	P11309	PIM1_HUMAN	non-specific serine/threonine protein kinase	337	Protein kinase.				cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	CGAGCATGACGAAGAGATCAT	0.532			T	BCL6	NHL								11	57					0	0	0	0	A	37140900	A	A	37140900	3	1	75	1	0	0	0	0	1	0	0	0	11982	1059	37	1	754	1	PIM1	6	37140900	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	8060660	37140900	133974167	40	15109											
KCNK5	8645	broad.mit.edu	37	chr6	39158899	39158899	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggccagcctccgtgttcaCgaaggtgatgctggcgtcct	6	9	14	12	3	1	1	1	1	0	0	3	3	3	1	4	3	2	2	4	3	1	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:39158899C>T	uc003oon.2	-	5	1631	c.1267G>A	c.(1267-1269)GTG>ATG	p.V423M		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	423					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						TCCGTGTTCACGAAGGTGATG	0.617													19	26					0	0	0	0	T	39158899	T	T	39158899	3	4	75	1	0	0	0	0	1	0	0	0	8108	536	19	1	236	1	KCNK5	6	39158899	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	2017999	39158899	131956168	41	15110											
MDN1	23195	broad.mit.edu	37	chr6	90368044	90368044	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccttcctctccaaagcctCtggcacctgctcctctgtat	5	13	5	18	0	3	0	0	0	3	0	7	0	6	0	6	1	2	3	6	1	2	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:90368044C>G	uc003pnn.1	-	90	15183	c.15067G>C	c.(15067-15069)GAG>CAG	p.E5023Q		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5023					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCCAAAGCCTCTGGCACCTGC	0.552													17	65					0	0	0	0	G	90368044	G	G	90368044	3	3	75	1	0	0	0	0	1	0	0	0	9468	922	32	2	1775	2	MDN1	6	90368044	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	51209145	90368044	80747023	42	15111											
CDC40	51362	broad.mit.edu	37	chr6	110501792	110501793	+	Frame_Shift_Del	DEL	TC	-	-																															aatcgccttcatcaaagccgTctctagcagtggcagtggac																										TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:110501792_110501793delTC	uc003pua.2	+	1	169_170	c.145_146delTC	c.(145-147)TCTfs	p.S49fs	WASF1_uc003ptv.1_5'Flank|WASF1_uc003ptw.1_5'Flank|WASF1_uc003ptx.1_5'Flank|WASF1_uc003pty.1_5'Flank|WASF1_uc003ptz.1_5'Flank	NM_015891	NP_056975	O60508	PRP17_HUMAN	cell division cycle 40 homolog	49					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)		ATCAAAGCCGTCTCTAGCAGTG	0.554													---	---	---								-	110501793	-	-	110501792	7	5	75	1	0	1	0	1	0	0	0	0	3085	1667	58	0	147	0	CDC40	6	110501792	Frame_Shift_Del	DEL	TC	TCGA-CN-6018-01A-11D-1683-08	20133748	110501792	60613275	43	15112											
AHI1	54806	broad.mit.edu	37	chr6	135769486	135769486	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgttgatgggtaatgatttCttggacattttgaccaccat	9	16	10	6	0	1	3	0	3	1	0	1	4	1	4	2	2	0	2	2	2	1	6			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:135769486C>G	uc003qgi.2	-	12	1952	c.1568G>C	c.(1567-1569)AGA>ACA	p.R523T	AHI1_uc003qgg.2_5'UTR|AHI1_uc003qgh.2_Missense_Mutation_p.R523T|AHI1_uc003qgj.2_Missense_Mutation_p.R523T|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Missense_Mutation_p.R523T	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	523						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		GTAATGATTTCTTGGACATTT	0.383													7	32					0	0	0	0	G	135769486	G	G	135769486	3	3	75	1	0	0	0	0	1	0	0	0	413	913	32	2	2151	2	AHI1	6	135769486	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	25267694	135769486	35345581	44	15113											
MAP3K4	4216	broad.mit.edu	37	chr6	161508788	161508788	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttgctgaggagaagagtatTattttgcagttactcaatgc	11	14	10	6	0	1	3	1	1	0	2	1	4	1	3	0	1	4	4	0	1	5	6			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr6:161508788T>C	uc003qtn.2	+	10	2767	c.2625T>C	c.(2623-2625)ATT>ATC	p.I875I	MAP3K4_uc010kkc.1_Silent_p.I875I|MAP3K4_uc003qto.2_Silent_p.I875I|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Silent_p.I328I	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	875					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		AGAAGAGTATTATTTTGCAGT	0.413													3	82					0	0	0	0	C	161508788	C	C	161508788	2	2	75	1	0	0	0	0	0	0	0	1	9305	1742	61	5		5	MAP3K4	6	161508788	Silent	SNP	T	TCGA-CN-6018-01A-11D-1683-08	25739302	161508788	9606279	45	15114											
SNX8	29886	broad.mit.edu	37	chr7	2317747	2317747	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagttacctggctggaaacCtcatactccacatgcttcag	10	10	7	14	0	2	0	2	0	0	0	3	1	3	1	4	2	4	3	4	2	3	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr7:2317747C>T	uc003slw.2	-	2	331	c.288G>A	c.(286-288)GAG>GAA	p.E96E		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	96	PX.				cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		GGCTGGAAACCTCATACTCCA	0.582													3	53					0	0	0	0	T	2317747	T	T	2317747	2	4	75	1	0	0	0	0	0	0	0	1	14972	680	24	4		4	SNX8	7	2317747	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08		2317747	156820916	46	15115											
TTYH3	80727	broad.mit.edu	37	chr7	2687663	2687663	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgctggttggcctcatcCgcagctccaagggcatcctg	5	10	13	13	1	1	0	1	0	0	0	4	0	4	0	4	4	2	5	4	4	1	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr7:2687663C>T	uc003smp.2	+	5	884	c.697C>T	c.(697-699)CGC>TGC	p.R233C	TTYH3_uc010ksn.2_Intron|TTYH3_uc003smq.2_Missense_Mutation_p.R62C	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	233	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		TGGCCTCATCCGCAGCTCCAA	0.682													8	51					0	0	0	0	T	2687663	T	T	2687663	3	4	75	1	0	0	0	0	1	0	0	0	16809	652	23	1	715	1	TTYH3	7	2687663	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	369916	2687663	156451000	47	15116											
ZAN	7455	broad.mit.edu	37	chr7	100345764	100345764	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctccctttctctccagtttgCcgtggtaggcgtttttggaa	4	16	10	11	2	1	0	0	0	1	0	4	1	3	1	3	3	1	3	3	3	2	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr7:100345764C>T	uc003uwj.2	+	10	1193	c.1028C>T	c.(1027-1029)GCC>GTC	p.A343V	ZAN_uc003uwk.2_Missense_Mutation_p.A343V|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	343	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTCCAGTTTGCCGTGGTAGGC	0.587													3	21					0	0	0	0	T	100345764	T	T	100345764	3	4	75	1	0	0	0	0	1	0	0	0	17581	739	26	4	1062	4	ZAN	7	100345764	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	97658101	100345764	58792899	48	15117											
ZC3HC1	51530	broad.mit.edu	37	chr7	129663445	129663445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtctcctgttcccatgcttCgggtcactgggcgagttctg	3	14	12	12	2	3	0	1	0	2	0	6	1	4	0	2	2	1	3	2	2	0	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr7:129663445C>T	uc003vpi.2	-	8	1166	c.1139G>A	c.(1138-1140)CGA>CAA	p.R380Q	ZC3HC1_uc003vph.2_Missense_Mutation_p.R224Q|ZC3HC1_uc010lma.2_Intron	NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	380					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					TCCCATGCTTCGGGTCACTGG	0.617													19	99					0	0	0	0	T	129663445	T	T	129663445	3	4	75	1	0	0	0	0	1	0	0	0	17644	884	31	1	381	1	ZC3HC1	7	129663445	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	29317681	129663445	29475218	49	15118											
TBXAS1	6916	broad.mit.edu	37	chr7	139661761	139661761	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcctggatgcccgacattCtgcaagtcccatgggcgtgc	6	9	13	13	2	1	0	0	0	1	0	3	2	3	1	3	3	3	1	3	3	1	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr7:139661761C>T	uc011kqv.1	+	10	1168	c.1004C>T	c.(1003-1005)TCT>TTT	p.S335F	TBXAS1_uc003vvh.2_Missense_Mutation_p.S289F|TBXAS1_uc010lne.2_Missense_Mutation_p.S221F|TBXAS1_uc011kqu.1_Missense_Mutation_p.S240F|TBXAS1_uc003vvi.2_Missense_Mutation_p.S289F|TBXAS1_uc003vvj.2_Missense_Mutation_p.S289F|TBXAS1_uc011kqw.1_Missense_Mutation_p.S269F	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	288	Lumenal (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					GCCCGACATTCTGCAAGTCCC	0.522													9	26					0	0	0	0	T	139661761	T	T	139661761	3	4	75	1	0	0	0	0	1	0	0	0	15730	913	32	2	1042	2	TBXAS1	7	139661761	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	9998316	139661761	19476902	50	15119											
UNC5D	137970	broad.mit.edu	37	chr8	35579850	35579850	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagtgactatggcgtggacGtcattgactcttctgcattg	8	13	12	8	2	3	3	1	2	2	1	3	4	3	4	0	2	1	1	0	2	1	4	rs149536132		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr8:35579850G>A	uc003xjr.1	+	9	1568	c.1240G>A	c.(1240-1242)GTC>ATC	p.V414I	UNC5D_uc003xjs.1_Missense_Mutation_p.V409I|UNC5D_uc003xju.1_5'Flank|UNC5D_uc003xjt.1_Missense_Mutation_p.V172I	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	414	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGGCGTGGACGTCATTGACTC	0.557													25	144					0	0	0	0	A	35579850	A	A	35579850	3	1	75	1	0	0	0	0	1	0	0	0	17063	1145	40	1	1274	1	UNC5D	8	35579850	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08		35579850	110784172	51	15120											
RALYL	138046	broad.mit.edu	37	chr8	85799988	85799988	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgggatagaggaggacttcGatgaagatgggggtcatgag	12	8	18	3	1	1	4	1	2	0	2	2	8	1	7	0	5	0	0	0	5	2	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr8:85799988G>A	uc003ycq.3	+	9	1251	c.835G>A	c.(835-837)GAT>AAT	p.D279N	RALYL_uc003ycr.3_Missense_Mutation_p.D279N|RALYL_uc003ycs.3_Missense_Mutation_p.D279N|RALYL_uc010lzy.2_Missense_Mutation_p.D268N|RALYL_uc003yct.3_Missense_Mutation_p.D292N|RALYL_uc003ycu.3_Missense_Mutation_p.D206N|RALYL_uc003ycv.3_Intron	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	279							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						GGAGGACTTCGATGAAGATGG	0.458													12	72					0	0	0	0	A	85799988	A	A	85799988	3	1	75	1	0	0	0	0	1	0	0	0	13085	1058	37	1	904	1	RALYL	8	85799988	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	50220138	85799988	60564034	52	15121											
CYP11B2	1585	broad.mit.edu	37	chr8	143999037	143999037	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cctgaaaatgggccccagctCctggaaggtctggtgcatct	8	9	12	12	0	2	1	0	1	2	0	3	2	3	2	4	4	2	2	4	4	3	0			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr8:143999037C>G	uc003yxk.1	-	1	223	c.220G>C	c.(220-222)GAG>CAG	p.E74Q		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	74					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGCCCCAGCTCCTGGAAGGTC	0.637									Familial_Hyperaldosteronism_type_I				12	58					0	0	0	0	G	143999037	G	G	143999037	3	3	75	1	0	0	0	0	1	0	0	0	4163	864	30	2	1327	2	CYP11B2	8	143999037	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	58199049	143999037	2364985	53	15122											
HEATR7A	727957	broad.mit.edu	37	chr8	145235410	145235410	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaagcaggacacggtgcgCgtggccttctgctccggtaa	7	7	14	13	4	1	0	0	0	1	0	2	1	2	1	3	4	3	3	3	4	2	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr8:145235410C>T	uc003zbk.3	+	7	783	c.546C>T	c.(544-546)CGC>CGT	p.R182R	HEATR7A_uc003zbg.2_Silent_p.R182R|HEATR7A_uc003zbh.3_Silent_p.R182R|HEATR7A_uc003zbi.3_Silent_p.R182R|HEATR7A_uc011lla.1_Silent_p.R182R|HEATR7A_uc010mft.2_Silent_p.R182R	NM_032450	NP_115826	Q8NDA8	HTR7A_HUMAN	HEAT repeat containing 7A isoform 1	182	HEAT 2.						binding				0						ACACGGTGCGCGTGGCCTTCT	0.657													12	44					0	0	0	0	T	145235410	T	T	145235410	2	4	75	1	0	0	0	0	0	0	0	1	7073	755	27	1		1	HEATR7A	8	145235410	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	1236373	145235410	1128612	54	15123											
ABCA1	19	broad.mit.edu	37	chr9	107558478	107558478	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgagaggtgtgattgaccaCctgttgagacacaaaaagat	15	9	11	6	0	0	5	0	4	0	3	0	7	0	5	2	1	0	1	2	1	2	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr9:107558478C>G	uc004bcl.2	-	39	5551	c.5238G>C	c.(5236-5238)GGG>GGC	p.G1746G		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1746	Helical; (Potential).			Missing (in Ref. 7; AAD49852).	Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGATTGACCACCTGTTGAGAC	0.512													24	25					0	0	0	0	G	107558478	G	G	107558478	2	3	75	1	0	0	0	0	0	0	0	1	28	521	18	4		4	ABCA1	9	107558478	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08		107558478	33654953	55	15124											
DLG5	9231	broad.mit.edu	37	chr10	79555860	79555860	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgacgccacagtggtcacatCgaaatggccgcttctccgct	8	9	10	14	4	2	1	1	1	1	0	4	2	2	1	3	2	0	2	3	2	1	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr10:79555860C>T	uc001jzk.2	-	29	5465	c.5395G>A	c.(5395-5397)GAT>AAT	p.D1799N	DLG5_uc001jzi.2_Missense_Mutation_p.D554N|DLG5_uc001jzj.2_Missense_Mutation_p.D1214N|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1799	Guanylate kinase-like.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GTGGTCACATCGAAATGGCCG	0.517													19	52					0	0	0	0	T	79555860	T	T	79555860	3	4	75	1	0	0	0	0	1	0	0	0	4580	884	31	1	380	1	DLG5	10	79555860	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08		79555860	55978887	56	15125											
MYOF	26509	broad.mit.edu	37	chr10	95191243	95191243	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggtcaccagtcaggtcCttcagggctacagtcgccgt	6	10	11	14	2	4	0	3	0	1	0	6	0	5	0	3	3	1	1	3	3	1	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr10:95191243C>A	uc001kin.2	-	4	390	c.267G>T	c.(265-267)AAG>AAT	p.K89N	MYOF_uc001kio.2_Missense_Mutation_p.K89N|MYOF_uc001kip.3_Missense_Mutation_p.K89N|MYOF_uc009xuf.2_Missense_Mutation_p.K71N	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	89	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						CAGTCAGGTCCTTCAGGGCTA	0.498													11	27					0.000673444	0.000717364	1	0	A	95191243	A	A	95191243	3	1	75	1	0	0	0	0	1	0	0	0	10142	680	24	4	6122	4	MYOF	10	95191243	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	15635383	95191243	40343504	57	15126											
MUC2	4583	broad.mit.edu	37	chr11	1098725	1098725	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agctgcttcatgccgggctcGagcctggagtgcgccagtct	5	9	14	13	3	2	0	1	0	1	0	3	2	2	1	3	2	5	3	3	2	0	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:1098725G>C	uc001lsx.1	+	40	14208	c.14181G>C	c.(14179-14181)TCG>TCC	p.S4727S		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4727						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TGCCGGGCTCGAGCCTGGAGT	0.647													2	5					0	0	0	0	C	1098725	C	C	1098725	2	2	75	1	0	0	0	0	0	0	0	1	10028	1045	37	3		3	MUC2	11	1098725	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08		1098725	133907791	58	15127											
ZNF195	7748	broad.mit.edu	37	chr11	3380843	3380843	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacattcttcacattggtaGggtttctctccggtgtgaat	7	15	9	10	1	3	1	1	1	2	0	5	1	4	1	2	3	0	2	2	3	2	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:3380843G>T	uc001lxt.2	-	6	1573	c.1395C>A	c.(1393-1395)CCC>CCA	p.P465P	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Silent_p.P442P|ZNF195_uc001lxs.2_Silent_p.P393P|ZNF195_uc010qxr.1_Silent_p.P446P|ZNF195_uc009ydz.2_Silent_p.P420P|ZNF195_uc001lxu.2_Silent_p.P397P	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		CACATTGGTAGGGTTTCTCTC	0.443													17	55					7.07596e-05	7.76243e-05	1	0	T	3380843	T	T	3380843	2	4	75	1	0	0	0	0	0	0	0	1	17825	987	35	4		4	ZNF195	11	3380843	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	2282118	3380843	131625673	59	15128											
TMEM179B	374395	broad.mit.edu	37	chr11	62556844	62556844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgtctgcctgtatccttcGatttggcaccaggtctctct	4	15	10	12	1	3	0	0	0	3	0	6	1	4	0	3	3	1	2	3	3	1	3	rs146539259		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:62556844G>A	uc001nvd.3	+	3	395	c.365G>A	c.(364-366)CGA>CAA	p.R122Q		NM_199337	NP_955369	Q7Z7N9	T179B_HUMAN	transmembrane protein 179B	122						integral to membrane					0						TGTATCCTTCGATTTGGCACC	0.537													5	29					0	0	0	0	A	62556844	A	A	62556844	3	1	75	1	0	0	0	0	1	0	0	0	16163	1058	37	1	375	1	TMEM179B	11	62556844	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	59176001	62556844	72449672	60	15129											
LTBP3	4054	broad.mit.edu	37	chr11	65315474	65315474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggggcccggcacgcactctCcgtggccacagatgttctgg	5	7	15	14	3	2	1	0	0	2	1	3	1	2	1	3	5	0	3	3	5	0	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:65315474C>T	uc001oej.2	-	12	2032	c.1763G>A	c.(1762-1764)GGA>GAA	p.G588E	LTBP3_uc001oeg.2_5'Flank|LTBP3_uc001oeh.2_Missense_Mutation_p.G18E|LTBP3_uc010roi.1_Missense_Mutation_p.G471E|LTBP3_uc001oei.2_Missense_Mutation_p.G588E|LTBP3_uc010roj.1_Missense_Mutation_p.G289E|LTBP3_uc010rok.1_Missense_Mutation_p.G499E	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	588	Cys-rich.|EGF-like 3.					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						CACGCACTCTCCGTGGCCACA	0.657													13	49					0	0	0	0	T	65315474	T	T	65315474	3	4	75	1	0	0	0	0	1	0	0	0	9125	855	30	2	2216	2	LTBP3	11	65315474	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	2758630	65315474	69691042	61	15130											
GDPD4	220032	broad.mit.edu	37	chr11	76969569	76969569	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggtcaaagtcatgcatgagGaaaggcacatgatcataact	16	8	10	7	0	3	2	3	2	0	0	3	3	3	3	0	3	2	2	0	3	3	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:76969569G>A	uc001oyf.2	-	10	977	c.726C>T	c.(724-726)TTC>TTT	p.F242F		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	242	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						CATGCATGAGGAAAGGCACAT	0.478													30	109					0	0	0	0	A	76969569	A	A	76969569	2	1	75	1	0	0	0	0	0	0	0	1	6363	1165	41	2		2	GDPD4	11	76969569	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	11654095	76969569	58036947	62	15131											
DLG2	1740	broad.mit.edu	37	chr11	83770508	83770508	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacatcaacctcattcacccGcaagatacaatcattgaccc	14	8	3	16	1	4	2	4	1	0	1	4	2	4	2	3	0	2	1	3	0	4	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:83770508G>A	uc001paj.2	-	6	757	c.454C>T	c.(454-456)CGG>TGG	p.R152W	DLG2_uc001pai.2_Missense_Mutation_p.R101W|DLG2_uc010rsy.1_Missense_Mutation_p.R119W|DLG2_uc010rsz.1_Missense_Mutation_p.R152W|DLG2_uc010rta.1_Missense_Mutation_p.R152W|DLG2_uc001pak.2_Missense_Mutation_p.R257W|DLG2_uc010rtb.1_Missense_Mutation_p.R119W|DLG2_uc001pal.1_Missense_Mutation_p.R152W|DLG2_uc001pam.1_Missense_Mutation_p.R191W	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	152	PDZ 1.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCATTCACCCGCAAGATACAA	0.443													3	22					0	0	0	0	A	83770508	A	A	83770508	3	1	75	1	0	0	0	0	1	0	0	0	4577	1086	38	1	2280	1	DLG2	11	83770508	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	6800939	83770508	51236008	63	15132											
EXPH5	23086	broad.mit.edu	37	chr11	108385200	108385200	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttgctctgagttgtggctGgaaaatgtaagcttcttgct	7	16	11	7	0	3	1	0	1	3	0	3	2	3	2	0	2	3	6	0	2	3	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:108385200G>A	uc001pkk.2	-	6	1145	c.1034C>T	c.(1033-1035)CCA>CTA	p.P345L	EXPH5_uc010rvy.1_Missense_Mutation_p.P157L|EXPH5_uc010rvz.1_Missense_Mutation_p.P189L|EXPH5_uc010rwa.1_Missense_Mutation_p.P269L	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	345					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AGTTGTGGCTGGAAAATGTAA	0.468													4	85					0	0	0	0	A	108385200	A	A	108385200	3	1	75	1	0	0	0	0	1	0	0	0	5347	1348	47	4	4939	4	EXPH5	11	108385200	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	24614692	108385200	26621316	64	15133											
DSCAML1	57453	broad.mit.edu	37	chr11	117335712	117335712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agagggccccgtgccagcccGattgaaggcttggaccacca	9	5	13	14	2	0	2	0	1	0	1	0	4	0	3	6	3	2	1	6	3	1	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:117335712G>A	uc001prh.1	-	17	3393	c.3391C>T	c.(3391-3393)CGG>TGG	p.R1131W		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1071	Extracellular (Potential).|Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GTGCCAGCCCGATTGAAGGCT	0.617													18	62					0	0	0	0	A	117335712	A	A	117335712	3	1	75	1	0	0	0	0	1	0	0	0	4791	1057	37	1	3018	1	DSCAML1	11	117335712	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	8950512	117335712	17670804	65	15134											
ABCG4	64137	broad.mit.edu	37	chr11	119029006	119029006	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcacacagttctgcatcctCttcaagaggaccttcctgtc	8	12	6	15	0	4	1	2	0	2	1	7	2	6	2	3	1	1	2	3	1	1	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:119029006C>G	uc001pvs.2	+	10	1467	c.1131C>G	c.(1129-1131)CTC>CTG	p.L377L	ABCG4_uc009zar.2_Silent_p.L377L	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	377	Cytoplasmic (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TCTGCATCCTCTTCAAGAGGA	0.572													42	315					0	0	0	0	G	119029006	G	G	119029006	2	3	75	1	0	0	0	0	0	0	0	1	70	900	32	2		2	ABCG4	11	119029006	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	1693294	119029006	15977510	66	15135											
BSX	390259	broad.mit.edu	37	chr11	122850040	122850040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggacaggtagcgctggatctCgaacctcttctccaagcccg	8	8	11	14	3	3	0	0	0	3	0	5	3	3	2	3	3	3	2	3	3	3	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:122850040C>T	uc010rzs.1	-	2	388	c.388G>A	c.(388-390)GAG>AAG	p.E130K		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	130	Homeobox.										0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		CGCTGGATCTCGAACCTCTTC	0.682													10	98					0	0	0	0	T	122850040	T	T	122850040	3	4	75	1	0	0	0	0	1	0	0	0	1540	893	31	1	320	1	BSX	11	122850040	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	3821034	122850040	12156476	67	15136											
FAM118B	79607	broad.mit.edu	37	chr11	126126666	126126666	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacaaggggattaaagtcAtctcctatggagatgactat	13	11	11	6	0	2	2	1	1	1	1	3	5	2	4	1	4	0	0	1	4	5	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr11:126126666A>G	uc001qdf.2	+	7	1084	c.901A>G	c.(901-903)ATC>GTC	p.I301V	FAM118B_uc009zca.2_Missense_Mutation_p.I305V|FAM118B_uc001qdg.2_Missense_Mutation_p.I301V	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	301											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		GATTAAAGTCATCTCCTATGG	0.433													53	168					0	0	0	0	G	126126666	G	G	126126666	3	3	75	1	0	0	0	0	1	0	0	0	5440	217	8	5	919	5	FAM118B	11	126126666	Missense_Mutation	SNP	A	TCGA-CN-6018-01A-11D-1683-08	3276626	126126666	8879850	68	15137											
WNK1	65125	broad.mit.edu	37	chr12	970337	970337	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcagtctcaaacagcaggtAgaacaatccagtgcttccca	14	7	8	12	0	1	1	1	0	1	1	4	1	3	1	2	1	5	4	2	1	4	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:970337A>G	uc001qio.3	+	7	2286	c.1779A>G	c.(1777-1779)GTA>GTG	p.V593V	WNK1_uc001qip.3_Silent_p.V593V|WNK1_uc001qir.3_Silent_p.V40V	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	593					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			AACAGCAGGTAGAACAATCCA	0.473													25	85					0	0	0	0	G	970337	G	G	970337	2	3	75	1	0	0	0	0	0	0	0	1	17445	407	15	5		5	WNK1	12	970337	Silent	SNP	A	TCGA-CN-6018-01A-11D-1683-08		970337	132881558	69	15138											
PAN2	9924	broad.mit.edu	37	chr12	56718209	56718209	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcctgaggcctcatctgaGtcagccaggattagaccgag	9	9	12	11	1	3	3	2	2	1	1	3	5	3	4	4	2	2	0	4	2	1	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:56718209G>A	uc001skx.2	-	12	2170	c.1797C>T	c.(1795-1797)GAC>GAT	p.D599D	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Silent_p.D599D|PAN2_uc001sky.2_Silent_p.D599D	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	599					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CCTCATCTGAGTCAGCCAGGA	0.498													5	51					0	0	0	0	A	56718209	A	A	56718209	2	1	75	1	0	0	0	0	0	0	0	1	11468	1020	36	4		4	PAN2	12	56718209	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	55747872	56718209	77133686	70	15139											
TMTC2	160335	broad.mit.edu	37	chr12	83359465	83359465	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctcatgcacacaagagctCtgttaccagttgtttgtaca	10	12	7	12	0	2	1	1	0	1	1	2	1	2	1	2	0	4	6	2	0	3	4			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:83359465C>G	uc001szt.2	+	6	2243	c.1811C>G	c.(1810-1812)TCT>TGT	p.S604C	TMTC2_uc001szr.1_Missense_Mutation_p.S604C|TMTC2_uc001szs.1_Missense_Mutation_p.S604C|TMTC2_uc010suk.1_Missense_Mutation_p.S359C	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	604						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CACAAGAGCTCTGTTACCAGT	0.488													4	71					0	0	0	0	G	83359465	G	G	83359465	3	3	75	1	0	0	0	0	1	0	0	0	16327	913	32	2	1833	2	TMTC2	12	83359465	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	26641256	83359465	50492430	71	15140											
WSCD2	9671	broad.mit.edu	37	chr12	108634156	108634156	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaccactggcgcagcggaCggaccatctgcatcaagacg	10	4	14	13	4	2	1	1	0	1	1	2	4	2	4	2	4	2	2	2	4	1	0			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:108634156C>T	uc001tms.2	+	8	1924	c.1180C>T	c.(1180-1182)CGG>TGG	p.R394W	WSCD2_uc001tmt.2_Missense_Mutation_p.R394W|WSCD2_uc001tmu.2_Missense_Mutation_p.R142W	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	394						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GCGCAGCGGACGGACCATCTG	0.617													12	147					0	0	0	0	T	108634156	T	T	108634156	3	4	75	1	0	0	0	0	1	0	0	0	17475	527	19	1	1206	1	WSCD2	12	108634156	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	25274691	108634156	25217739	72	15141											
UBE3B	89910	broad.mit.edu	37	chr12	109972413	109972414	+	Missense_Mutation	DNP	GG	TT	TT																															caggacaccggggacactctGggcagcgtcctccggggctt																										TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:109972413_109972414GG>TT	uc001top.2	+	28	3636_3637	c.3033_3034GG>TT	c.(3031-3036)CTGGGC>CTTTGC	p.G1012C	UBE3B_uc001toq.2_Missense_Mutation_p.G1012C|UBE3B_uc001tos.2_Missense_Mutation_p.G439C|UBE3B_uc001tot.2_Missense_Mutation_p.G130C|UBE3B_uc010sxp.1_3'UTR	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	1012	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GGGACACTCTGGGCAGCGTCCT	0.649													12	41					0	0	0	0	TT	109972414	TT	TT	109972413	3	4	75	1	0	0	0	0	1	0	0	0	16948	1335	47	4	3135	4	UBE3B	12	109972413	Missense_Mutation	DNP	GG	TCGA-CN-6018-01A-11D-1683-08	1338257	109972413	23879482	73	15142											
POLE	5426	broad.mit.edu	37	chr12	133202825	133202825	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgggcctcctcggagaactCgccgacatccaccaggcgaa	9	5	11	16	4	0	1	0	0	0	1	4	4	2	1	5	3	1	0	5	3	2	0			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr12:133202825C>T	uc001uks.1	-	46	6453	c.6409G>A	c.(6409-6411)GAG>AAG	p.E2137K	POLE_uc001ukq.1_Missense_Mutation_p.E347K|POLE_uc001ukr.1_Missense_Mutation_p.E941K|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	2137					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TCGGAGAACTCGCCGACATCC	0.602								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					4	25					0	0	0	0	T	133202825	T	T	133202825	3	4	75	1	0	0	0	0	1	0	0	0	12251	893	31	1	467	1	POLE	12	133202825	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	23230412	133202825	649070	74	15143											
SACS	26278	broad.mit.edu	37	chr13	23906534	23906534	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgccaagttctaaaggtagCttgtacaaataaggtttaaa	15	12	9	5	0	1	0	0	0	1	0	1	0	1	0	1	2	3	5	1	2	9	8			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr13:23906534C>T	uc001uon.2	-	10	12070	c.11481G>A	c.(11479-11481)AAG>AAA	p.K3827K	SACS_uc001uoo.2_Silent_p.K3680K|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3827					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTAAAGGTAGCTTGTACAAAT	0.358													14	54					0	0	0	0	T	23906534	T	T	23906534	2	4	75	1	0	0	0	0	0	0	0	1	13869	796	28	4		4	SACS	13	23906534	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08		23906534	91263344	75	15144											
STARD13	90627	broad.mit.edu	37	chr13	33703846	33703846	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgacttgccagagcatgggAgcccttttctgcaggcaggt	7	10	13	11	1	1	1	0	0	1	1	2	3	1	2	2	3	4	3	2	3	0	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr13:33703846A>T	uc001uuw.2	-	5	1094	c.968T>A	c.(967-969)CTC>CAC	p.L323H	STARD13_uc001uuu.2_Missense_Mutation_p.L315H|STARD13_uc001uuv.2_Missense_Mutation_p.L205H|STARD13_uc001uux.2_Missense_Mutation_p.L288H|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.L308H	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	323					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AGAGCATGGGAGCCCTTTTCT	0.597													4	42					0	0	0	0	T	33703846	T	T	33703846	3	4	75	1	0	0	0	0	1	0	0	0	15322	304	11	5	2413	5	STARD13	13	33703846	Missense_Mutation	SNP	A	TCGA-CN-6018-01A-11D-1683-08	9797312	33703846	81466032	76	15145											
GPC5	2262	broad.mit.edu	37	chr13	92345977	92345977	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctggcgcacatggcggagCttaatccacactggcatgca	9	7	12	13	2	0	0	0	0	0	0	1	1	1	1	2	4	2	4	2	4	1	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr13:92345977C>A	uc010tif.1	+	3	1228	c.862C>A	c.(862-864)CTT>ATT	p.L288I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	288						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CATGGCGGAGCTTAATCCACA	0.532													7	61					0.00307968	0.00325693	1	0	A	92345977	A	A	92345977	3	1	75	1	0	0	0	0	1	0	0	0	6639	797	28	4	872	4	GPC5	13	92345977	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	58642131	92345977	22823901	77	15146											
LRFN5	145581	broad.mit.edu	37	chr14	42356945	42356945	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacacaaatagtggatcttCatataattaagctccctcac	15	11	4	11	0	3	0	2	0	1	0	4	1	4	1	1	1	2	1	1	1	6	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr14:42356945C>T	uc001wvm.2	+	3	2315	c.1117C>T	c.(1117-1119)CAT>TAT	p.H373Y	LRFN5_uc010ana.2_Missense_Mutation_p.H373Y	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	373	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AGTGGATCTTCATATAATTAA	0.403										HNSCC(30;0.082)			11	54					0	0	0	0	T	42356945	T	T	42356945	3	4	75	1	0	0	0	0	1	0	0	0	8991	826	29	2	1119	2	LRFN5	14	42356945	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08		42356945	64992595	78	15147											
SAV1	60485	broad.mit.edu	37	chr14	51132173	51132173	+	Frame_Shift_Del	DEL	T	-	-																															taatctgttgctttctcttcTcattatttcatgaggtgttc																										TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr14:51132173delT	uc001wyg.1	-	3	420	c.259delA	c.(259-261)AGAfs	p.R87fs	SAV1_uc001wyh.1_Frame_Shift_Del_p.R87fs	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	WW45 protein	87					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)	1	all_epithelial(31;0.000611)|Breast(41;0.0333)					CTTTCTCTTCTCATTATTTCA	0.393													---	---	---								-	51132173	-	-	51132173	7	5	75	1	0	1	0	1	0	0	0	0	13921	1559	54	0	908	0	SAV1	14	51132173	Frame_Shift_Del	DEL	T	TCGA-CN-6018-01A-11D-1683-08	8775228	51132173	56217367	79	15148											
NRXN3	9369	broad.mit.edu	37	chr14	79933658	79933658	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcggtctgaccgccttgcCgtgggcttcagcaccactgt	5	9	12	15	4	2	1	1	1	1	0	2	1	2	1	4	2	2	2	4	2	0	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr14:79933658C>T	uc001xun.2	+	13	2729	c.2238C>T	c.(2236-2238)GCC>GCT	p.A746A	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Silent_p.A114A|NRXN3_uc010asw.2_Silent_p.A114A|NRXN3_uc001xur.3_Silent_p.A114A	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1119	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		ACCGCCTTGCCGTGGGCTTCA	0.577													15	50					0	0	0	0	T	79933658	T	T	79933658	2	4	75	1	0	0	0	0	0	0	0	1	10721	639	23	1		1	NRXN3	14	79933658	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	28801485	79933658	27415882	80	15149											
RASGRP1	10125	broad.mit.edu	37	chr15	38805096	38805096	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgttgcacagagcaatagatCgctccatggtggggttttcc	8	11	12	10	2	0	2	0	0	0	2	3	2	2	2	2	3	2	5	2	3	2	4			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:38805096C>T	uc001zke.3	-	7	915	c.737G>A	c.(736-738)CGA>CAA	p.R246Q	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Missense_Mutation_p.R108Q|RASGRP1_uc010bbg.2_Missense_Mutation_p.R108Q|RASGRP1_uc001zkd.3_Missense_Mutation_p.R246Q	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	246	Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		AGCAATAGATCGCTCCATGGT	0.468													3	18					0	0	0	0	T	38805096	T	T	38805096	3	4	75	1	0	0	0	0	1	0	0	0	13139	884	31	1	1700	1	RASGRP1	15	38805096	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08		38805096	63726296	81	15150											
TGM5	9333	broad.mit.edu	37	chr15	43552685	43552685	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggttgaaggcctggccccGgcgaacaagcaggtggtcca	9	5	16	11	2	0	1	0	1	0	0	1	3	1	1	4	6	2	2	4	6	3	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:43552685G>A	uc001zrd.1	-	2	111	c.103C>T	c.(103-105)CGG>TGG	p.R35W	TGM5_uc001zre.1_Missense_Mutation_p.R35W	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	35					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GCCTGGCCCCGGCGAACAAGC	0.572													18	134					0	0	0	0	A	43552685	A	A	43552685	3	1	75	1	0	0	0	0	1	0	0	0	15899	1115	39	1	2107	1	TGM5	15	43552685	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	4747589	43552685	58978707	82	15151											
ALDH1A2	8854	broad.mit.edu	37	chr15	58256141	58256141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactacgcgcctcttggccCgctccacgcttcttctcaca	5	10	6	20	4	3	0	1	0	3	0	5	0	4	0	4	1	1	2	4	1	1	4			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:58256141C>T	uc002aex.2	-	9	1086	c.1028G>A	c.(1027-1029)CGG>CAG	p.R343Q	ALDH1A2_uc002aey.2_Missense_Mutation_p.R305Q|ALDH1A2_uc010ugv.1_Missense_Mutation_p.R322Q|ALDH1A2_uc010ugw.1_Missense_Mutation_p.R314Q|ALDH1A2_uc002aew.2_Missense_Mutation_p.R247Q	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	343					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CCTCTTGGCCCGCTCCACGCT	0.527													9	56					0	0	0	0	T	58256141	T	T	58256141	3	4	75	1	0	0	0	0	1	0	0	0	491	652	23	1	548	1	ALDH1A2	15	58256141	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	14703456	58256141	44275251	83	15152											
KIAA1024	23251	broad.mit.edu	37	chr15	79755583	79755583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgagttggccgaggtgaagCggggccaaccttcttggacc	7	7	15	12	3	1	1	0	1	1	0	1	4	1	2	5	5	2	1	5	5	2	3	rs61746211	byFrequency	TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:79755583C>T	uc002bew.1	+	3	2548	c.2473C>T	c.(2473-2475)CGG>TGG	p.R825W	KIAA1024_uc010unk.1_Missense_Mutation_p.R825W	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	825						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						CGAGGTGAAGCGGGGCCAACC	0.617													7	63					0	0	0	0	T	79755583	T	T	79755583	3	4	75	1	0	0	0	0	1	0	0	0	8244	759	27	1	2479	1	KIAA1024	15	79755583	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	21499442	79755583	22775809	84	15153											
ARNT2	9915	broad.mit.edu	37	chr15	80845025	80845025	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatgaatgggatgtcggtGcccacagagttcttatcccg	9	10	12	10	2	1	2	0	1	1	1	3	4	2	3	2	2	1	1	2	2	2	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:80845025G>A	uc002bfr.2	+	10	1165	c.999G>A	c.(997-999)GTG>GTA	p.V333V	ARNT2_uc010unm.1_Silent_p.V322V|ARNT2_uc002bfs.2_Silent_p.V322V	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	333	PAS 2.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			GGATGTCGGTGCCCACAGAGT	0.498													9	85					0	0	0	0	A	80845025	A	A	80845025	2	1	75	1	0	0	0	0	0	0	0	1	968	1306	46	4		4	ARNT2	15	80845025	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	1089442	80845025	21686367	85	15154											
KIAA1199	57214	broad.mit.edu	37	chr15	81181835	81181835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggagtggacggagtggttcGatcatgataaagtatctcag	11	11	14	5	2	2	1	2	1	1	0	4	5	2	4	0	4	0	2	0	4	3	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr15:81181835G>A	uc002bfw.1	+	9	1248	c.988G>A	c.(988-990)GAT>AAT	p.D330N	KIAA1199_uc010unn.1_Missense_Mutation_p.D330N	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	330										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GGAGTGGTTCGATCATGATAA	0.473													5	57					0	0	0	0	A	81181835	A	A	81181835	3	1	75	1	0	0	0	0	1	0	0	0	8252	1058	37	1	1018	1	KIAA1199	15	81181835	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	336810	81181835	21349557	86	15155											
NUP93	9688	broad.mit.edu	37	chr16	56875619	56875619	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttttctctctatgtagatCaggcacaacctctcagaagt	10	14	7	10	0	4	2	2	0	3	2	6	2	4	2	1	1	1	3	1	1	4	4			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr16:56875619C>A	uc002eka.2	+	21	2344	c.2223C>A	c.(2221-2223)ATC>ATA	p.I741I	NUP93_uc002ekb.2_Silent_p.I618I|NUP93_uc010vhi.1_Silent_p.I618I	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	741					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						CTATGTAGATCAGGCACAACC	0.522													16	113					4.14922e-12	4.62072e-12	1	0	A	56875619	A	A	56875619	2	1	75	1	0	0	0	0	0	0	0	1	10826	816	29	2		2	NUP93	16	56875619	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08		56875619	33479134	87	15156											
DOK4	55715	broad.mit.edu	37	chr16	57509069	57509069	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggttctcccagactgatgtCgttgaggcgggaccccagac	8	8	13	12	2	1	4	0	2	1	2	3	5	1	5	3	3	0	2	3	3	0	2	rs111834942	byFrequency	TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr16:57509069C>T	uc010cdb.2	-	4	650	c.352G>A	c.(352-354)GAC>AAC	p.D118N	DOK4_uc002elu.1_Missense_Mutation_p.D118N|DOK4_uc002elv.3_Missense_Mutation_p.D118N	NM_018110	NP_060580	Q8TEW6	DOK4_HUMAN	docking protein 4	118							insulin receptor binding			skin(1)	1						AGACTGATGTCGTTGAGGCGG	0.552													21	90					0	0	0	0	T	57509069	T	T	57509069	3	4	75	1	0	0	0	0	1	0	0	0	4721	884	31	1	648	1	DOK4	16	57509069	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	633450	57509069	32845684	88	15157											
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	6	8	16	11	2	1	1	1	1	0	0	2	3	2	2	4	5	2	2	4	5	0	1	rs121912651		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	30					0	0	0	0	A	7577539	A	A	7577539	3	1	75	1	0	0	0	0	1	0	0	0	16448	1115	39	1	548	1	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08		7577539	73617671	89	15158											
ZNF18	7566	broad.mit.edu	37	chr17	11895781	11895781	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cattgccacagtctctggggGtcccccttcaagctttccac	6	11	8	16	0	2	0	1	0	1	0	5	0	4	0	4	2	2	1	4	2	1	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:11895781G>T	uc002gng.1	-	4	971	c.366C>A	c.(364-366)GAC>GAA	p.D122E	ZNF18_uc002gnh.1_Missense_Mutation_p.D122E|ZNF18_uc002gni.1_Missense_Mutation_p.D122E	NM_144680	NP_653281	P17022	ZNF18_HUMAN	zinc finger protein 18	122	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)	1				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		GTCTCTGGGGGTCCCCCTTCA	0.517													8	57					5.18039e-06	5.7257e-06	1	0	T	11895781	T	T	11895781	3	4	75	1	0	0	0	0	1	0	0	0	17814	1252	44	4	1307	4	ZNF18	17	11895781	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	4318242	11895781	69299429	90	15159											
CCDC144NL	339184	broad.mit.edu	37	chr17	20799105	20799105	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgccaagatcttccaggcGgacatcgtgctggagctggt	7	9	13	12	3	1	1	0	0	1	1	4	3	2	3	2	4	2	2	2	4	1	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:20799105G>A	uc002gyf.2	-	1	349	c.229C>T	c.(229-231)CGC>TGC	p.R77C	uc002gyg.1_Intron|uc002gyh.1_Intron	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	77											0						TCTTCCAGGCGGACATCGTGC	0.642													15	69					0	0	0	0	A	20799105	A	A	20799105	3	1	75	1	0	0	0	0	1	0	0	0	2791	1116	39	1	452	1	CCDC144NL	17	20799105	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	8903324	20799105	60396105	91	15160											
KCNJ12	3768	broad.mit.edu	37	chr17	21319815	21319815	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggccttcctgagccgtgaCgaggaggatgaggcggacgg	7	6	18	10	4	0	3	0	3	0	0	1	7	1	6	3	6	1	0	3	6	0	1	rs144041366		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:21319815C>T	uc002gyv.1	+	3	1866	c.1161C>T	c.(1159-1161)GAC>GAT	p.D387D		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	387	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TGAGCCGTGACGAGGAGGATG	0.662										Prostate(3;0.18)			4	58					0	0	0	0	T	21319815	T	T	21319815	2	4	75	1	0	0	0	0	0	0	0	1	8085	535	19	1		1	KCNJ12	17	21319815	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	520710	21319815	59875395	92	15161											
HNF1B	6928	broad.mit.edu	37	chr17	36091644	36091644	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggggggagccgtgggagagCagagggttcaggctgtgagt	7	7	22	5	1	1	3	1	1	0	2	1	5	1	4	1	6	2	3	1	6	0	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:36091644C>T	uc002hok.3	-	4	1208	c.987G>A	c.(985-987)CTG>CTA	p.L329L	HNF1B_uc010wdi.1_Silent_p.L303L|HNF1B_uc010cve.1_Silent_p.L137L	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	329					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			CGTGGGAGAGCAGAGGGTTCA	0.587									Hereditary_Prostate_Cancer				5	25					0	0	0	0	T	36091644	T	T	36091644	2	4	75	1	0	0	0	0	0	0	0	1	7291	697	25	4		4	HNF1B	17	36091644	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	14771829	36091644	45103566	93	15162											
SLC38A10	124565	broad.mit.edu	37	chr17	79226463	79226463	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggctcgtggcggtgggcctCgcccacaggcacagcaatcc	7	5	14	15	3	0	0	0	0	0	0	3	0	1	0	3	5	1	3	3	5	1	0			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr17:79226463C>T	uc002jzz.1	-	13	1852	c.1477G>A	c.(1477-1479)GAG>AAG	p.E493K	SLC38A10_uc002jzy.1_Missense_Mutation_p.E411K|SLC38A10_uc002kab.2_Missense_Mutation_p.E493K	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	493					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CGGTGGGCCTCGCCCACAGGC	0.607													15	41					0	0	0	0	T	79226463	T	T	79226463	3	4	75	1	0	0	0	0	1	0	0	0	14666	893	31	1	2176	1	SLC38A10	17	79226463	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	43134819	79226463	1968747	94	15163											
PDE4A	5141	broad.mit.edu	37	chr19	10571734	10571734	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcttcgcggctgccatccacGatgtggatcaccctggggtc	5	10	12	14	3	2	0	1	0	1	0	5	2	3	1	3	4	1	1	3	4	0	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:10571734G>A	uc002moj.2	+	11	1528	c.1420G>A	c.(1420-1422)GAT>AAT	p.D474N	PDE4A_uc002mok.2_Missense_Mutation_p.D448N|PDE4A_uc002mol.2_Missense_Mutation_p.D413N|PDE4A_uc002mom.2_Missense_Mutation_p.D235N|PDE4A_uc002mon.2_5'UTR|PDE4A_uc002moo.2_Missense_Mutation_p.D140N	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	474	Catalytic.	Divalent metal cation 2.|cAMP (By similarity).|Divalent metal cation 1.			signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	TGCCATCCACGATGTGGATCA	0.577													6	20					0	0	0	0	A	10571734	A	A	10571734	3	1	75	1	0	0	0	0	1	0	0	0	11693	1058	37	1	1919	1	PDE4A	19	10571734	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08		10571734	48557249	95	15164											
ZNF99	7652	broad.mit.edu	37	chr19	22939423	22939423	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgccacattcttcacatttGtacggtttctccccagtatg	7	16	6	12	1	3	0	1	0	2	0	4	0	3	0	3	1	2	3	3	1	2	7			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:22939423G>T	uc010xrh.1	-	7	2748	c.2748C>A	c.(2746-2748)TAC>TAA	p.Y916*		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CTTCACATTTGTACGGTTTCT	0.378													6	26					8.12818e-05	8.85069e-05	1	0	T	22939423	T	T	22939423	4	4	75	1	0	0	0	0	0	1	0	0	18271	1372	48	4	368	4	ZNF99	19	22939423	Nonsense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	12367689	22939423	36189560	96	15165											
HNRNPL	3191	broad.mit.edu	37	chr19	39329085	39329086	+	Frame_Shift_Ins	INS	-	A	A																															gcggggcgttgaagaagtgcINSagcacgttgctggggtgctg																										TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:39329085_39329086insA	uc010xul.1	-	10	1519_1520	c.1508_1509insT	c.(1507-1509)CTGfs	p.L503fs	HNRNPL_uc010ege.1_Intron|HNRNPL_uc002ojj.1_Frame_Shift_Ins_p.L159fs|HNRNPL_uc002ojo.1_Frame_Shift_Ins_p.L81fs|HNRNPL_uc002ojk.2_Frame_Shift_Ins_p.L159fs|HNRNPL_uc002ojl.2_Frame_Shift_Ins_p.L159fs|HNRNPL_uc010xum.1_Frame_Shift_Ins_p.L370fs	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	503					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			TGAAGAAGTGCAGCACGTTGCT	0.599													---	---	---								A	39329086	A	A	39329085	7	5	75	1	0	1	1	0	0	0	0	0	7309	697	25	0	276	0	HNRNPL	19	39329085	Frame_Shift_Ins	INS	-	TCGA-CN-6018-01A-11D-1683-08	16389662	39329085	19799898	97	15166											
EXOC3L2	90332	broad.mit.edu	37	chr19	45719439	45719439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaccacggcatccagccacGaggcctgggactcctgcagg	8	4	13	16	2	0	0	0	0	0	0	2	2	2	1	5	4	2	3	5	4	0	0			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:45719439G>A	uc002pay.1	-	9	874	c.833C>T	c.(832-834)TCG>TTG	p.S278L		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	278	Potential.									ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		ATCCAGCCACGAGGCCTGGGA	0.617													5	33					0	0	0	0	A	45719439	A	A	45719439	3	1	75	1	0	0	0	0	1	0	0	0	5329	1059	37	1	404	1	EXOC3L2	19	45719439	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	6390354	45719439	13409544	98	15167											
CA11	770	broad.mit.edu	37	chr19	49143424	49143424	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagctccaaacagcagccgCagttcactgagtcggtggct	9	7	12	13	3	1	1	1	1	0	0	3	2	2	1	2	2	4	5	2	2	1	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:49143424C>G	uc002pjz.1	-	4	961	c.399G>C	c.(397-399)CTG>CTC	p.L133L	SEC1_uc010xzv.1_Intron|SEC1_uc002pka.2_Intron|SEC1_uc010xzw.1_Intron|SEC1_uc010ema.2_Intron|DBP_uc002pjx.3_5'Flank|DBP_uc002pjy.2_5'Flank|DBP_uc010elz.1_5'Flank	NM_001217	NP_001208	O75493	CAH11_HUMAN	carbonic anhydrase XI precursor	133						extracellular region					0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000103)|all cancers(93;0.000119)|GBM - Glioblastoma multiforme(486;0.00634)|Epithelial(262;0.016)		ACAGCAGCCGCAGTTCACTGA	0.592													20	53					0	0	0	0	G	49143424	G	G	49143424	2	3	75	1	0	0	0	0	0	0	0	1	2524	697	25	4		4	CA11	19	49143424	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	3423985	49143424	9985559	99	15168											
ZNF649	65251	broad.mit.edu	37	chr19	52394690	52394690	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccacacaagctacacccgtgGggtttctctcctctgtgagc	7	10	9	15	1	2	1	0	1	2	0	4	1	3	1	3	2	3	2	3	2	2	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:52394690G>T	uc002pxy.2	-	5	967	c.699C>A	c.(697-699)CCC>CCA	p.P233P	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TACACCCGTGGGGTTTCTCTC	0.502													13	61					0.000151284	0.000163521	1	0	T	52394690	T	T	52394690	2	4	75	1	0	0	0	0	0	0	0	1	18131	1219	43	4		4	ZNF649	19	52394690	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	3251266	52394690	6734293	100	15169											
ZNF665	79788	broad.mit.edu	37	chr19	53669070	53669070	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctccagtatggatgacctGatggattgttaggtttgaac	9	15	11	6	0	1	3	0	3	1	0	2	5	1	5	2	3	1	3	2	3	3	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:53669070G>A	uc010eqm.1	-	4	773	c.673C>T	c.(673-675)CAG>TAG	p.Q225*		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	160	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TGGATGACCTGATGGATTGTT	0.403													7	69					0	0	0	0	A	53669070	A	A	53669070	4	1	75	1	0	0	0	0	0	1	0	0	18140	1299	45	2	1367	2	ZNF665	19	53669070	Nonsense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	1274380	53669070	5459913	101	15170											
ZIM2	23619	broad.mit.edu	37	chr19	57286846	57286846	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcattgttataggagtcaaaAgtttctcttggttgccctgg	8	16	10	7	0	3	0	2	0	1	0	4	1	3	1	1	3	1	3	1	3	4	6			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:57286846A>C	uc002qnr.2	-	11	1176	c.794T>G	c.(793-795)CTT>CGT	p.L265R	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_Missense_Mutation_p.L61R|ZIM2_uc010ygr.1_Missense_Mutation_p.L61R|ZIM2_uc002qnq.2_Missense_Mutation_p.L265R|ZIM2_uc010etp.2_Missense_Mutation_p.L265R|ZIM2_uc010ygs.1_Missense_Mutation_p.L265R	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		AGGAGTCAAAAGTTTCTCTTG	0.443													12	45					0	0	0	0	C	57286846	C	C	57286846	3	2	75	1	0	0	0	0	1	0	0	0	17751	72	3	5	793	5	ZIM2	19	57286846	Missense_Mutation	SNP	A	TCGA-CN-6018-01A-11D-1683-08	3617776	57286846	1842137	102	15171											
ZNF154	7710	broad.mit.edu	37	chr19	58213789	58213789	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaagtctccaatggtcattGagactgtagcttttgctaaa	11	14	9	7	0	2	2	1	2	1	1	3	3	2	2	1	1	2	3	1	1	5	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:58213789G>C	uc010euf.2	-	3	768	c.528C>G	c.(526-528)CTC>CTG	p.L176L	ZNF776_uc002qpx.2_Intron|ZNF154_uc002qpy.2_RNA	NM_001085384	NP_001078853	Q13106	ZN154_HUMAN	zinc finger protein 154	176	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AATGGTCATTGAGACTGTAGC	0.453													19	111					0	0	0	0	C	58213789	C	C	58213789	2	2	75	1	0	0	0	0	0	0	0	1	17802	1277	45	2		2	ZNF154	19	58213789	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	926943	58213789	915194	103	15172											
ZSCAN22	342945	broad.mit.edu	37	chr19	58850557	58850557	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtccgaaggcctttgcacaGagctcctccctcattgagca	8	10	9	14	1	1	2	1	1	0	1	4	3	4	2	4	1	3	3	4	1	1	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr19:58850557G>C	uc002qsc.2	+	3	1488	c.1341G>C	c.(1339-1341)CAG>CAC	p.Q447H	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	447	C2H2-type 7.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		CCTTTGCACAGAGCTCCTCCC	0.557													7	58					0	0	0	0	C	58850557	C	C	58850557	3	2	75	1	0	0	0	0	1	0	0	0	18301	933	33	2	1347	2	ZSCAN22	19	58850557	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	636768	58850557	278426	104	15173											
PAK7	57144	broad.mit.edu	37	chr20	9561425	9561425	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaagccattttcttccgcGtggcctggaccgtggctgga	6	11	13	11	3	1	1	0	1	1	0	2	3	2	3	4	4	1	1	4	4	1	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr20:9561425G>A	uc002wnl.2	-	5	902	c.357C>T	c.(355-357)CAC>CAT	p.H119H	PAK7_uc002wnk.2_Silent_p.H119H|PAK7_uc002wnj.2_Silent_p.H119H|PAK7_uc010gby.1_Silent_p.H119H	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	119	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TTTCTTCCGCGTGGCCTGGAC	0.527													19	141					0	0	0	0	A	9561425	A	A	9561425	2	1	75	1	0	0	0	0	0	0	0	1	11459	1136	40	1		1	PAK7	20	9561425	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08		9561425	53464095	105	15174											
MATN4	8785	broad.mit.edu	37	chr20	43932984	43932984	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgcagggagcccacgtccGcgcgctgcacccccaccgcg	5	2	13	21	8	0	0	0	0	0	0	1	1	1	1	5	1	2	3	5	1	0	0			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr20:43932984G>A	uc002xnn.2	-	3	714	c.527C>T	c.(526-528)GCG>GTG	p.A176V	MATN4_uc002xno.2_Missense_Mutation_p.A176V|MATN4_uc002xnp.2_Missense_Mutation_p.A176V|MATN4_uc010zwr.1_Missense_Mutation_p.A124V|MATN4_uc002xnr.1_Missense_Mutation_p.A176V|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	176	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				GCCCACGTCCGCGCGCTGCAC	0.692													7	36					0	0	0	0	A	43932984	A	A	43932984	3	1	75	1	0	0	0	0	1	0	0	0	9389	1087	38	1	1250	1	MATN4	20	43932984	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	34371559	43932984	19092536	106	15175											
CTCFL	140690	broad.mit.edu	37	chr20	56087700	56087700	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacctcttctcattcttaTgagttttctggtgctgaatg	7	18	8	8	0	4	3	1	3	4	0	5	3	4	3	1	1	2	2	1	1	3	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr20:56087700T>C	uc010gix.1	-	7	2101	c.1439A>G	c.(1438-1440)CAT>CGT	p.H480R	CTCFL_uc010giw.1_Missense_Mutation_p.H480R|CTCFL_uc002xym.2_Missense_Mutation_p.H480R|CTCFL_uc010giz.1_Missense_Mutation_p.H68R|CTCFL_uc010giy.1_Missense_Mutation_p.H150R|CTCFL_uc010gja.1_Missense_Mutation_p.H430R|CTCFL_uc010gjb.1_Missense_Mutation_p.H480R|CTCFL_uc010gjc.1_Missense_Mutation_p.H480R|CTCFL_uc010gjd.1_Missense_Mutation_p.H480R|CTCFL_uc010gje.2_Missense_Mutation_p.H480R|CTCFL_uc010gjf.2_Missense_Mutation_p.H275R|CTCFL_uc010gjg.2_Missense_Mutation_p.H212R|CTCFL_uc010gjh.1_Intron|CTCFL_uc010gji.1_Missense_Mutation_p.H275R|CTCFL_uc010gjj.1_Missense_Mutation_p.H480R	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	480	C2H2-type 8.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CTCATTCTTATGAGTTTTCTG	0.458													10	64					0	0	0	0	C	56087700	C	C	56087700	3	2	75	1	0	0	0	0	1	0	0	0	4018	1464	51	5	568	5	CTCFL	20	56087700	Missense_Mutation	SNP	T	TCGA-CN-6018-01A-11D-1683-08	12154716	56087700	6937820	107	15176											
ZNF831	128611	broad.mit.edu	37	chr20	57766526	57766526	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgtccgcactgtggtcGcgactgcctgaagcccagtg	5	9	13	14	3	0	1	0	1	0	0	2	2	1	1	4	1	2	1	4	1	1	0			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr20:57766526G>A	uc002yan.2	+	1	452	c.452G>A	c.(451-453)CGC>CAC	p.R151H		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	151	C2H2-type 1.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CACTGTGGTCGCGACTGCCTG	0.662													30	105					0	0	0	0	A	57766526	A	A	57766526	3	1	75	1	0	0	0	0	1	0	0	0	18252	1087	38	1	454	1	ZNF831	20	57766526	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	1678826	57766526	5258994	108	15177											
TPTE	7179	broad.mit.edu	37	chr21	11012949	11012949	+	RNA	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttttgtgacaatttgtgctAcaagtgaagatccacagcag	12	12	9	8	0	0	3	0	2	0	1	1	3	1	3	1	0	3	2	1	0	4	4			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr21:11012949A>G	uc002yis.1	-	9		c.1672T>C						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATTTGTGCTACAAGTGAAGA	0.279													5	16					0	0	0	0	G	11012949	G	G	11012949	1	3	75	0	1	0	0	0	0	0	0	0	16497	406	14	5		5	TPTE	21	11012949	RNA	SNP	A	TCGA-CN-6018-01A-11D-1683-08		11012949	37116946	109	15178											
DOPEY2	9980	broad.mit.edu	37	chr21	37652617	37652617	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgaccatcttttgactcatGagaaaacaatgtttaaggat	14	14	7	6	0	2	3	1	3	1	1	2	5	2	4	1	1	1	1	1	1	4	5			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr21:37652617G>A	uc002yvg.2	+	31	6083	c.6004G>A	c.(6004-6006)GAG>AAG	p.E2002K	DOPEY2_uc011aeb.1_Missense_Mutation_p.E1951K	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	2002					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TTTGACTCATGAGAAAACAAT	0.308													9	30					0	0	0	0	A	37652617	A	A	37652617	3	1	75	1	0	0	0	0	1	0	0	0	4730	1291	45	2	6122	2	DOPEY2	21	37652617	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	26639668	37652617	10477278	110	15179											
CBS	875	broad.mit.edu	37	chr21	44474014	44474014	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctggtcccgctcctgggcGgccacgaagttcagcaagtc	6	9	12	14	3	2	0	1	0	1	0	5	1	4	0	3	3	1	3	3	3	2	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr21:44474014G>A	uc002zcu.2	-	17	1877	c.1632C>T	c.(1630-1632)GCC>GCT	p.A544A	CBS_uc002zcs.1_Silent_p.A439A|CBS_uc002zct.2_Silent_p.A544A|CBS_uc002zcw.3_Silent_p.A544A|CBS_uc002zcv.2_Silent_p.A544A	NM_000071	NP_000062	P35520	CBS_HUMAN	cystathionine-beta-synthase	544					cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	GCTCCTGGGCGGCCACGAAGT	0.647													6	36					0	0	0	0	A	44474014	A	A	44474014	2	1	75	1	0	0	0	0	0	0	0	1	2723	1103	39	1		1	CBS	21	44474014	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	6821397	44474014	3655881	111	15180											
GNAZ	2781	broad.mit.edu	37	chr22	23465286	23465286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccccagagtcggatggcaGagagcttgcgcctctttgac	7	10	12	12	2	1	3	0	1	1	2	3	5	2	4	3	2	2	2	3	2	0	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr22:23465286G>A	uc002zwu.1	+	3	1273	c.736G>A	c.(736-738)GAG>AAG	p.E246K	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	246						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		TCGGATGGCAGAGAGCTTGCG	0.542													12	41					0	0	0	0	A	23465286	A	A	23465286	3	1	75	1	0	0	0	0	1	0	0	0	6551	943	33	2	742	2	GNAZ	22	23465286	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08		23465286	27839280	112	15181											
ELFN2	114794	broad.mit.edu	37	chr22	37770765	37770765	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttgaagcccgagttctcGtctggctccctctgggcgtc	3	11	14	13	3	3	1	0	1	3	0	6	2	4	1	2	3	1	3	2	3	1	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr22:37770765G>A	uc003asq.3	-	3	1596	c.810C>T	c.(808-810)GAC>GAT	p.D270D		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	270	Extracellular (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					CCGAGTTCTCGTCTGGCTCCC	0.687													9	40					0	0	0	0	A	37770765	A	A	37770765	2	1	75	1	0	0	0	0	0	0	0	1	5082	1136	40	1		1	ELFN2	22	37770765	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	14305479	37770765	13533801	113	15182											
POLDIP3	84271	broad.mit.edu	37	chr22	42999092	42999092	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggaaggtggctgtgcgtGttgactggctgagaaggcct	6	10	18	7	1	0	2	0	2	0	1	0	4	0	3	1	5	1	4	1	5	2	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr22:42999092G>A	uc003bcu.2	-	2	233	c.134C>T	c.(133-135)ACA>ATA	p.T45I	POLDIP3_uc011app.1_5'UTR|POLDIP3_uc003bcv.2_Missense_Mutation_p.T45I|POLDIP3_uc011apq.1_Missense_Mutation_p.T45I|POLDIP3_uc010gza.2_RNA|POLDIP3_uc011apr.1_RNA|POLDIP3_uc010gzb.1_Missense_Mutation_p.T45I	NM_032311	NP_115687	Q9BY77	PDIP3_HUMAN	DNA polymerase delta interacting protein 3	45					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding				0						GGCTGTGCGTGTTGACTGGCT	0.527													5	69					0	0	0	0	A	42999092	A	A	42999092	3	1	75	1	0	0	0	0	1	0	0	0	12250	1377	48	4	1163	4	POLDIP3	22	42999092	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	5228327	42999092	8305474	114	15183											
BRD1	23774	broad.mit.edu	37	chr22	50181097	50181097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagtctccgcatgtgctcCgcgaccttttccttggctgc	3	12	11	15	4	1	0	0	0	1	0	4	2	3	1	4	2	2	3	4	2	0	3	rs140147452		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr22:50181097C>T	uc003biv.2	-	7	2892	c.2405G>A	c.(2404-2406)CGG>CAG	p.R802Q	BRD1_uc011arf.1_Missense_Mutation_p.R528Q|BRD1_uc011arg.1_Missense_Mutation_p.R851Q|BRD1_uc011arh.1_Missense_Mutation_p.R802Q|BRD1_uc003biu.3_Missense_Mutation_p.R933Q	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	802					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCATGTGCTCCGCGACCTTTT	0.602													9	39					0	0	0	0	T	50181097	T	T	50181097	3	4	75	1	0	0	0	0	1	0	0	0	1506	652	23	1	795	1	BRD1	22	50181097	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	7182005	50181097	1123469	115	15184											
TYMP	1890	broad.mit.edu	37	chr22	50967607	50967607	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggtgcgaggaccaggctGaccttgtcacccacaccccc	8	5	11	17	1	1	1	1	1	0	0	1	3	1	2	5	3	1	2	5	3	0	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chr22:50967607G>A	uc003bmb.3	-	2	495	c.375C>T	c.(373-375)GTC>GTT	p.V125V	TYMP_uc003bmc.3_Silent_p.V125V|TYMP_uc003bmd.3_Silent_p.V125V|TYMP_uc010hbd.2_Silent_p.V125V|TYMP_uc003bme.3_Silent_p.V125V|TYMP_uc003bmf.3_Silent_p.V125V|TYMP_uc011arz.1_Silent_p.V125V	NM_001113756	NP_001107228	P19971	TYPH_HUMAN	endothelial cell growth factor 1	125					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			ovary(1)	1		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	GGACCAGGCTGACCTTGTCAC	0.637													5	52					0	0	0	0	A	50967607	A	A	50967607	2	1	75	1	0	0	0	0	0	0	0	1	16879	1277	45	2		2	TYMP	22	50967607	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	786510	50967607	336959	116	15185											
TIMP1	7076	broad.mit.edu	37	chrX	47442865	47442865	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctgttgttgctgtggctGatagcccccagcagggcctg	5	11	13	12	0	0	1	0	1	0	0	1	1	1	1	4	2	3	5	4	2	1	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:47442865G>A	uc004dif.2	+	2	243	c.51G>A	c.(49-51)CTG>CTA	p.L17L	SYN1_uc004did.2_Intron|SYN1_uc004die.2_Intron|TIMP1_uc011mlr.1_5'UTR|TIMP1_uc010nht.1_5'UTR	NM_003254	NP_003245	P01033	TIMP1_HUMAN	tissue inhibitor of metalloproteinase 1	17					erythrocyte maturation|negative regulation of membrane protein ectodomain proteolysis|platelet activation|platelet degranulation|positive regulation of cell proliferation	platelet alpha granule lumen	metal ion binding|metalloendopeptidase inhibitor activity|protein binding				0						TGCTGTGGCTGATAGCCCCCA	0.652													6	64					0	0	0	0	A	47442865	A	A	47442865	2	1	75	1	0	0	0	0	0	0	0	1	15983	1277	45	2		2	TIMP1	23	47442865	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08		47442865	107827695	117	15186											
ZC3H12B	340554	broad.mit.edu	37	chrX	64722774	64722774	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcatgccagctgggacccGctgccctgtacaactgactc	8	7	10	16	1	0	1	0	1	0	0	1	2	0	2	3	1	6	4	3	1	2	1			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:64722774G>A	uc010nko.2	+	5	2172	c.2163G>A	c.(2161-2163)CCG>CCA	p.P721P		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	721							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						GCTGGGACCCGCTGCCCTGTA	0.577													14	27					0	0	0	0	A	64722774	A	A	64722774	2	1	75	1	0	0	0	0	0	0	0	1	17629	1074	38	1		1	ZC3H12B	23	64722774	Silent	SNP	G	TCGA-CN-6018-01A-11D-1683-08	17279909	64722774	90547786	118	15187											
CYSLTR1	10800	broad.mit.edu	37	chrX	77529009	77529009	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgaacataatagaccacacGgagaggcagtgtgcacacac	15	5	11	10	1	0	3	0	1	0	2	0	4	0	3	1	2	2	2	1	2	3	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:77529009G>A	uc004edb.2	-	3	635	c.235C>T	c.(235-237)CGT>TGT	p.R79C	CYSLTR1_uc010nma.2_Missense_Mutation_p.R79C|CYSLTR1_uc010nmb.2_Missense_Mutation_p.R79C	NM_006639	NP_006630	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	79	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			ovary(1)	1					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	TAGACCACACGGAGAGGCAGT	0.423													7	54					0	0	0	0	A	77529009	A	A	77529009	3	1	75	1	0	0	0	0	1	0	0	0	4218	1116	39	1	782	1	CYSLTR1	23	77529009	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	12806235	77529009	77741551	119	15188											
TAF7L	54457	broad.mit.edu	37	chrX	100538563	100538563	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttcaacaactgcatggcGcccatcagctgaagagaagt	13	8	9	11	1	2	2	2	1	0	1	2	3	2	2	1	1	5	2	1	1	5	2	rs145455495		TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:100538563G>A	uc004ehb.2	-	4	424	c.412C>T	c.(412-414)CGC>TGC	p.R138C	TAF7L_uc004eha.2_Missense_Mutation_p.R52C|TAF7L_uc004ehc.1_Missense_Mutation_p.R52C	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	138					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						ACTGCATGGCGCCCATCAGCT	0.398													95	165					0	0	0	0	A	100538563	A	A	100538563	3	1	75	1	0	0	0	0	1	0	0	0	15599	1087	38	1	1016	1	TAF7L	23	100538563	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	23009554	100538563	54731997	120	15189											
DOCK11	139818	broad.mit.edu	37	chrX	117699986	117699986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgccccaaaatgcgccgtCatgcttttgaactcaagatg	11	10	9	11	2	2	2	2	1	0	1	2	2	2	2	3	0	4	1	3	0	4	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:117699986C>T	uc004eqp.2	+	8	775	c.712C>T	c.(712-714)CAT>TAT	p.H238Y	DOCK11_uc004eqq.2_Missense_Mutation_p.H4Y	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	238	PH.				blood coagulation	cytosol	GTP binding			ovary(3)	3						AATGCGCCGTCATGCTTTTGA	0.333													20	185					0	0	0	0	T	117699986	T	T	117699986	3	4	75	1	0	0	0	0	1	0	0	0	4708	826	29	2	742	2	DOCK11	23	117699986	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	17161423	117699986	37570574	121	15190											
GRIA3	2892	broad.mit.edu	37	chrX	122561966	122561966	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatatgggaccctggactcCggttcaacaaaagaattttt	12	11	9	9	1	1	1	1	0	0	1	2	3	2	3	2	3	1	2	2	3	5	4			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:122561966C>T	uc004etq.3	+	13	2345	c.2052C>T	c.(2050-2052)TCC>TCT	p.S684S	GRIA3_uc004etr.3_Silent_p.S684S|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	684	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	CCCTGGACTCCGGTTCAACAA	0.423													6	82					0	0	0	0	T	122561966	T	T	122561966	2	4	75	1	0	0	0	0	0	0	0	1	6808	639	23	1		1	GRIA3	23	122561966	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	4861980	122561966	32708594	122	15191											
ODZ1	10178	broad.mit.edu	37	chrX	124097537	124097537	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatcagaagaactggtgtaAgctagatccatttcatgctt	12	13	8	8	0	3	3	3	0	0	3	4	3	4	3	1	1	3	3	1	1	4	4			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:124097537A>T	uc004euj.2	-	1	130	c.66T>A	c.(64-66)GCT>GCA	p.A22A	ODZ1_uc011muj.1_Silent_p.A22A|ODZ1_uc010nqy.2_Silent_p.A22A	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	22	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AACTGGTGTAAGCTAGATCCA	0.443													32	251					0	0	0	0	T	124097537	T	T	124097537	2	4	75	1	0	0	0	0	0	0	0	1	10888	59	3	5		5	ODZ1	23	124097537	Silent	SNP	A	TCGA-CN-6018-01A-11D-1683-08	1535571	124097537	31173023	123	15192											
HS6ST2	90161	broad.mit.edu	37	chrX	132091167	132091167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcgggtgaaattgtagcgggGcacgaacctggcggagctct	8	7	17	9	4	1	1	0	1	1	0	1	3	1	2	1	5	3	3	1	5	3	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:132091167G>A	uc011mve.1	-	3	1032	c.616C>T	c.(616-618)CCC>TCC	p.P206S	HS6ST2_uc011mvb.1_Missense_Mutation_p.P60S|HS6ST2_uc011mvc.1_Missense_Mutation_p.P60S|HS6ST2_uc011mvd.1_Missense_Mutation_p.P206S	NM_147175	NP_671704	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2 isoform	206	Lumenal (Potential).					integral to membrane	sulfotransferase activity				0	Acute lymphoblastic leukemia(192;0.000127)					TTGTAGCGGGGCACGAACCTG	0.652													15	43					0	0	0	0	A	132091167	A	A	132091167	3	1	75	1	0	0	0	0	1	0	0	0	7410	1203	42	4	1337	4	HS6ST2	23	132091167	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	7993630	132091167	23179393	124	15193											
MAGEA10	4109	broad.mit.edu	37	chrX	151303808	151303808	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggaagggaagcaacgacCgagggggaggagcaggctat	14	3	18	6	2	0	0	0	0	0	0	0	6	0	4	1	6	3	3	1	6	5	1	rs139926957	byFrequency	TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:151303808C>T	uc004ffk.2	-	5	693	c.285G>A	c.(283-285)TCG>TCA	p.S95S	MAGEA10_uc004ffl.2_Silent_p.S95S	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	95											0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCAACGACCGAGGGGGAGG	0.532													15	264					0	0	0	0	T	151303808	T	T	151303808	2	4	75	1	0	0	0	0	0	0	0	1	9215	639	23	1		1	MAGEA10	23	151303808	Silent	SNP	C	TCGA-CN-6018-01A-11D-1683-08	19212641	151303808	3966752	125	15194											
RENBP	5973	broad.mit.edu	37	chrX	153207481	153207481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccagcacagcttgtccatCcctctaccgggaaggagcag	9	7	10	15	1	1	0	0	0	1	0	4	2	4	2	4	2	4	3	4	2	2	2			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:153207481C>T	uc004fjo.1	-	7	861	c.691G>A	c.(691-693)GAT>AAT	p.D231N	RENBP_uc011mzh.1_Intron	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	231					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	GCTTGTCCATCCCTCTACCGG	0.617													7	107					0	0	0	0	T	153207481	T	T	153207481	3	4	75	1	0	0	0	0	1	0	0	0	13290	855	30	2	612	2	RENBP	23	153207481	Missense_Mutation	SNP	C	TCGA-CN-6018-01A-11D-1683-08	1903673	153207481	2063079	126	15195											
GDI1	2664	broad.mit.edu	37	chrX	153670046	153670046	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaggctggccaggttatccGcatcatctgtatccttagcc	8	11	10	12	1	2	0	1	0	1	0	4	1	4	0	4	3	1	4	4	3	4	3			TCGA-CN-6018-01A-11D-1683-08	TCGA-CN-6018-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	33815edd-bb4f-4f05-bc82-94eafe423652	f3b1312a-5ef1-4312-811e-223f4f4cb997	g.chrX:153670046G>A	uc004fli.3	+	8	1238	c.896G>A	c.(895-897)CGC>CAC	p.R299H	GDI1_uc011mzo.1_3'UTR|GDI1_uc004flj.2_5'Flank|FAM50A_uc004fll.3_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	299					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAGGTTATCCGCATCATCTGT	0.572													7	90					0	0	0	0	A	153670046	A	A	153670046	3	1	75	1	0	0	0	0	1	0	0	0	6357	1087	38	1	926	1	GDI1	23	153670046	Missense_Mutation	SNP	G	TCGA-CN-6018-01A-11D-1683-08	462565	153670046	1600514	127	15196											
ZZZ3	26009	broad.mit.edu	37	chr1	78099026	78099026	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcttgtaacacgagtagatCgggaagcagccatactatgg	13	9	11	8	2	1	1	0	0	1	1	2	3	1	2	1	2	4	3	1	2	5	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr1:78099026C>T	uc001dhq.2	-	5	490	c.14G>A	c.(13-15)CGA>CAA	p.R5Q	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.R5Q|ZZZ3_uc001dhp.2_Missense_Mutation_p.R5Q	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						ACGAGTAGATCGGGAAGCAGC	0.403													4	28					0	0	0	0	T	78099026	T	T	78099026	3	4	76	1	0	0	0	0	1	0	0	0	18323	884	31	1	2741	1	ZZZ3	1	78099026	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08		78099026	171151595	1	15197											
PTBP2	58155	broad.mit.edu	37	chr1	97272478	97272478	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaataagaaagacagcgctCtaatacagatggctgatgga	17	7	10	7	1	1	4	0	1	1	3	1	5	1	5	0	2	2	2	0	2	5	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr1:97272478C>T	uc001drq.2	+	11	1381	c.1135C>T	c.(1135-1137)CTA>TTA	p.L379L	PTBP2_uc001drn.2_Silent_p.L384L|PTBP2_uc001dro.2_Silent_p.L379L|PTBP2_uc010otz.1_Silent_p.L395L|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Silent_p.L327L|PTBP2_uc001drr.2_Silent_p.L384L|PTBP2_uc010oua.1_Silent_p.L387L|PTBP2_uc001dru.2_RNA|PTBP2_uc001drs.1_5'UTR|PTBP2_uc001drt.2_5'UTR	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	379	RRM 3.						nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		AGACAGCGCTCTAATACAGAT	0.348													4	52					0	0	0	0	T	97272478	T	T	97272478	2	4	76	1	0	0	0	0	0	0	0	1	12788	912	32	2		2	PTBP2	1	97272478	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08	19173452	97272478	151978143	2	15198											
OLFM3	118427	broad.mit.edu	37	chr1	102270200	102270200	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattaggtcgatgtcagagAatccaccccatgtgtagggg	10	9	12	10	1	1	1	1	0	0	1	3	3	2	1	4	3	0	1	4	3	3	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr1:102270200A>G	uc001duf.2	-	6	1102	c.1031T>C	c.(1030-1032)TTC>TCC	p.F344S	OLFM3_uc001dug.2_Missense_Mutation_p.F324S|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.F249S|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	344	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		GATGTCAGAGAATCCACCCCA	0.453													13	37					0	0	0	0	G	102270200	G	G	102270200	3	3	76	1	0	0	0	0	1	0	0	0	10908	246	9	5	409	5	OLFM3	1	102270200	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	4997722	102270200	146980421	3	15199											
CELSR2	1952	broad.mit.edu	37	chr1	109812137	109812137	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgggccctggacaaacccGtcacggtgcagttccgcctg	6	6	12	17	4	1	0	1	0	0	0	2	1	2	1	5	3	2	2	5	3	1	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr1:109812137G>T	uc001dxa.3	+	21	6965	c.6904G>T	c.(6904-6906)GTC>TTC	p.V2302F		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2302	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GGACAAACCCGTCACGGTGCA	0.607													8	32					0.000157383	0.000176813	1	0	T	109812137	T	T	109812137	3	4	76	1	0	0	0	0	1	0	0	0	3237	1145	40	3	6986	3	CELSR2	1	109812137	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	7541937	109812137	139438484	4	15200											
LY9	4063	broad.mit.edu	37	chr1	160769743	160769743	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctacctgggccgactagacAtcaccaagtggagttactcc	10	8	10	13	1	1	1	1	0	0	1	2	3	2	2	4	2	2	2	4	2	4	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr1:160769743A>T	uc001fwu.2	+	2	375	c.325A>T	c.(325-327)ATC>TTC	p.I109F	LY9_uc001fwt.2_Missense_Mutation_p.I109F|LY9_uc010pjs.1_Missense_Mutation_p.I109F|LY9_uc001fwv.2_Missense_Mutation_p.I109F|LY9_uc001fww.2_Missense_Mutation_p.I109F|LY9_uc001fwx.2_Missense_Mutation_p.I109F|LY9_uc001fwy.1_Missense_Mutation_p.I11F	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	109	Extracellular (Potential).|Ig-like V-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCGACTAGACATCACCAAGTG	0.453													21	74					0	0	0	0	T	160769743	T	T	160769743	3	4	76	1	0	0	0	0	1	0	0	0	9152	217	8	5	331	5	LY9	1	160769743	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	50957606	160769743	88480878	5	15201											
TNN	63923	broad.mit.edu	37	chr1	175046803	175046803	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggccagggaggaacagaaCatcatcttcaggcacaacat	15	5	11	10	0	3	1	2	0	1	1	3	4	3	3	1	4	3	1	1	4	3	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr1:175046803C>T	uc001gkl.1	+	2	362	c.249C>T	c.(247-249)AAC>AAT	p.N83N	TNN_uc010pmx.1_Silent_p.N83N	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	83					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGGAACAGAACATCATCTTCA	0.617													17	50					0	0	0	0	T	175046803	T	T	175046803	2	4	76	1	0	0	0	0	0	0	0	1	16389	477	17	4		4	TNN	1	175046803	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08	14277060	175046803	74203818	6	15202											
USH2A	7399	broad.mit.edu	37	chr1	215940123	215940123	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctgtagttggtgtatggCtggagacctagaaaaagcaa	14	9	13	5	0	0	2	0	0	0	2	0	3	0	2	1	3	2	6	1	3	7	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr1:215940123C>G	uc001hku.1	-	56	11334	c.10947G>C	c.(10945-10947)CAG>CAC	p.Q3649H		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3649	Extracellular (Potential).|Fibronectin type-III 21.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTGTATGGCTGGAGACCTA	0.423										HNSCC(13;0.011)			11	50					0	0	0	0	G	215940123	G	G	215940123	3	3	76	1	0	0	0	0	1	0	0	0	17104	796	28	4	4729	4	USH2A	1	215940123	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	40893320	215940123	33310498	7	15203											
USH2A	7399	broad.mit.edu	37	chr1	216373318	216373318	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaataggaatgatataactTaaagtcaagtttccctctgg	14	12	7	8	0	2	1	1	1	1	0	3	2	3	2	2	2	1	1	2	2	8	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr1:216373318T>A	uc001hku.1	-	17	3849	c.3462A>T	c.(3460-3462)TTA>TTT	p.L1154F	USH2A_uc001hkv.2_Missense_Mutation_p.L1154F	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1154	Extracellular (Potential).|Fibronectin type-III 2.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGATATAACTTAAAGTCAAGT	0.423										HNSCC(13;0.011)			16	95					0	0	0	0	A	216373318	A	A	216373318	3	1	76	1	0	0	0	0	1	0	0	0	17104	1751	61	5	12384	5	USH2A	1	216373318	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	433195	216373318	32877303	8	15204											
APOB	338	broad.mit.edu	37	chr2	21255246	21255246	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgttgaccgcgtggctcagCgcatacaaggtggctcggct	6	10	14	11	4	1	1	1	1	0	0	2	1	1	1	1	4	2	5	1	4	2	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:21255246C>T	uc002red.2	-	10	1460	c.1332G>A	c.(1330-1332)GCG>GCA	p.A444A		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	444	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CGTGGCTCAGCGCATACAAGG	0.547													4	75					0	0	0	0	T	21255246	T	T	21255246	2	4	76	1	0	0	0	0	0	0	0	1	785	755	27	1		1	APOB	2	21255246	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08		21255246	221944127	9	15205											
DNMT3A	1788	broad.mit.edu	37	chr2	25463264	25463264	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcgatcatctccctccttGggccgcgcatcatgcaggag	6	8	13	14	3	3	0	2	0	1	0	5	2	4	1	3	3	1	2	3	3	0	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:25463264G>A	uc002rgc.2	-	19	2486	c.2229C>T	c.(2227-2229)CCC>CCT	p.P743P	DNMT3A_uc002rgd.2_Silent_p.P743P|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.P554P	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	743					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCCCTCCTTGGGCCGCGCAT	0.567			Mis|F|N|S		AML								22	85					0	0	0	0	A	25463264	A	A	25463264	2	1	76	1	0	0	0	0	0	0	0	1	4698	1335	47	4		4	DNMT3A	2	25463264	Silent	SNP	G	TCGA-CN-6019-01A-11D-1683-08	4208018	25463264	217736109	10	15206											
SMEK2	57223	broad.mit.edu	37	chr2	55808822	55808822	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgttcaattaccacattaaTaagaagaatatcctggtggc	14	13	7	7	0	1	2	1	0	0	2	2	2	2	2	2	2	1	1	2	2	7	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:55808822T>A	uc002rzc.2	-	8	1621	c.1246A>T	c.(1246-1248)ATT>TTT	p.I416F	SMEK2_uc002rzb.2_Missense_Mutation_p.I416F|SMEK2_uc002rzd.2_Missense_Mutation_p.I416F|SMEK2_uc002rza.2_Missense_Mutation_p.I292F	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	416						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACCACATTAATAAGAAGAATA	0.348													12	48					0	0	0	0	A	55808822	A	A	55808822	3	1	76	1	0	0	0	0	1	0	0	0	14858	1406	49	5	1343	5	SMEK2	2	55808822	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	30345558	55808822	187390551	11	15207											
ST6GAL2	84620	broad.mit.edu	37	chr2	107459975	107459975	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcccgtgggcctggctccccGggggaagggaatcccaatgt	6	7	15	13	2	0	0	0	0	0	0	3	2	3	2	5	5	0	1	5	5	3	0	rs142520495		TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:107459975G>A	uc002tdq.2	-	2	578	c.459C>T	c.(457-459)CCC>CCT	p.P153P	ST6GAL2_uc002tdr.2_Silent_p.P153P|ST6GAL2_uc002tds.3_Silent_p.P153P	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	153	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CTGGCTCCCCGGGGGAAGGGA	0.622													16	252					0	0	0	0	A	107459975	A	A	107459975	2	1	76	1	0	0	0	0	0	0	0	1	15288	1103	39	1		1	ST6GAL2	2	107459975	Silent	SNP	G	TCGA-CN-6019-01A-11D-1683-08	51651153	107459975	135739398	12	15208											
SPOPL	339745	broad.mit.edu	37	chr2	139316621	139316621	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtccaagattcagtaaacatAtcaggacatactaatacaaa	19	9	5	8	0	2	1	2	0	0	1	3	2	3	2	1	1	3	1	1	1	8	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:139316621A>C	uc002tvh.2	+	6	910	c.510A>C	c.(508-510)ATA>ATC	p.I170I		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	170						nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		CAGTAAACATATCAGGACATA	0.353													14	77					0	0	0	0	C	139316621	C	C	139316621	2	2	76	1	0	0	0	0	0	0	0	1	15151	439	16	5		5	SPOPL	2	139316621	Silent	SNP	A	TCGA-CN-6019-01A-11D-1683-08	31856646	139316621	103882752	13	15209											
SPOPL	339745	broad.mit.edu	37	chr2	139316682	139316683	+	Missense_Mutation	DNP	GG	TT	TT																															gtcgtctagcagaagatttaGgtaatctctgggaaaacaca																										TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:139316682_139316683GG>TT	uc002tvh.2	+	6	971_972	c.571_572GG>TT	c.(571-573)GGT>TTT	p.G191F		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	191						nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		AGAAGATTTAGGTAATCTCTGG	0.366													27	100					0	0	0	0	TT	139316683	TT	TT	139316682	3	4	76	1	0	0	0	0	1	0	0	0	15151	1000	35	4	589	4	SPOPL	2	139316682	Missense_Mutation	DNP	GG	TCGA-CN-6019-01A-11D-1683-08	61	139316682	103882691	14	15210											
TANC1	85461	broad.mit.edu	37	chr2	160031502	160031502	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccaggctgacaacacgtaCacttgcctggtgcccgagtt	8	9	11	13	2	0	1	0	1	0	0	0	2	0	1	3	2	5	3	3	2	2	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:160031502C>G	uc002uag.2	+	12	1816	c.1542C>G	c.(1540-1542)TAC>TAG	p.Y514*	TANC1_uc010fol.1_Nonsense_Mutation_p.Y408*|TANC1_uc010zcm.1_Nonsense_Mutation_p.Y506*|TANC1_uc010fom.1_Nonsense_Mutation_p.Y320*|TANC1_uc002uai.1_5'Flank	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	514						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						ACAACACGTACACTTGCCTGG	0.577													46	308					0	0	0	0	G	160031502	G	G	160031502	4	3	76	1	0	0	0	0	0	1	0	0	15610	489	17	4	1580	4	TANC1	2	160031502	Nonsense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	20714820	160031502	83167871	15	15211											
GAD1	2571	broad.mit.edu	37	chr2	171686090	171686090	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcctgtgaaaacagcgaccGggatgcccgcttccggcgca	8	7	12	14	5	0	1	0	1	0	0	2	3	2	2	4	2	3	2	4	2	2	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:171686090G>T	uc002ugi.2	+	4	673	c.251G>T	c.(250-252)CGG>CTG	p.R84L	GAD1_uc002ugh.2_Missense_Mutation_p.R84L	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	84					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AACAGCGACCGGGATGCCCGC	0.547													4	89					0.000602214	0.000660259	1	0	T	171686090	T	T	171686090	3	4	76	1	0	0	0	0	1	0	0	0	6213	1116	39	3	261	3	GAD1	2	171686090	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	11654588	171686090	71513283	16	15212											
NFE2L2	4780	broad.mit.edu	37	chr2	178098950	178098950	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtcaaatacttctcgacttActccaagatctatatcttgc	12	14	4	11	1	4	1	1	0	3	1	6	2	5	1	1	0	3	0	1	0	6	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:178098950A>C	uc002ulh.3	-	2	650	c.95T>G	c.(94-96)GTA>GGA	p.V32G	NFE2L2_uc002ulg.3_Missense_Mutation_p.V16G|NFE2L2_uc010zfa.1_Missense_Mutation_p.V16G|NFE2L2_uc002uli.3_Missense_Mutation_p.V16G|NFE2L2_uc010fra.2_Missense_Mutation_p.V16G|NFE2L2_uc010frb.2_Missense_Mutation_p.V16G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	32					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TTCTCGACTTACTCCAAGATC	0.368			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			6	34					0	0	0	0	C	178098950	C	C	178098950	3	2	76	1	0	0	0	0	1	0	0	0	10422	391	14	5	1738	5	NFE2L2	2	178098950	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	6412860	178098950	65100423	17	15213											
PDE11A	50940	broad.mit.edu	37	chr2	178936794	178936794	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggccttggagcgggcaaaaCtcttccttagctctttctga	7	13	10	11	1	3	1	0	1	3	0	4	2	4	2	2	3	3	2	2	3	3	4	rs149522660	byFrequency	TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:178936794C>T	uc002ulq.2	-	1	689	c.371G>A	c.(370-372)AGT>AAT	p.S124N	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	124					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GCGGGCAAAACTCTTCCTTAG	0.612									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				17	54					0	0	0	0	T	178936794	T	T	178936794	3	4	76	1	0	0	0	0	1	0	0	0	11685	565	20	4	2510	4	PDE11A	2	178936794	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	837844	178936794	64262579	18	15214											
TTN	7273	broad.mit.edu	37	chr2	179598558	179598558	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctctcacagcagcttgcagGgtaacggtttgtcctcctag	7	11	10	13	1	1	0	1	0	1	0	4	0	3	0	3	2	4	5	3	2	2	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:179598558G>T	uc010zfg.1	-	50	12050	c.11826C>A	c.(11824-11826)ACC>ACA	p.T3942T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T603T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4869							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTTGCAGGGTAACGGTTT	0.413													14	72					1.3612e-06	1.62986e-06	1	0	T	179598558	T	T	179598558	2	4	76	1	0	0	0	0	0	0	0	1	16803	1219	43	4		4	TTN	2	179598558	Silent	SNP	G	TCGA-CN-6019-01A-11D-1683-08	661764	179598558	63600815	19	15215											
TTN	7273	broad.mit.edu	37	chr2	179640610	179640610	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atttactgcgcagctcttccGactcttcaggcactttttca	7	15	6	13	2	4	0	2	0	2	0	5	1	5	0	1	1	3	3	1	1	1	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:179640610G>A	uc010zfg.1	-	28	6205	c.5981C>T	c.(5980-5982)TCG>TTG	p.S1994L	TTN_uc010zfh.1_Missense_Mutation_p.S1948L|TTN_uc010zfi.1_Missense_Mutation_p.S1948L|TTN_uc010zfj.1_Missense_Mutation_p.S1948L|TTN_uc002unb.2_Missense_Mutation_p.S1994L|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1994							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTCTTCCGACTCTTCAGG	0.438													21	126					0	0	0	0	A	179640610	A	A	179640610	3	1	76	1	0	0	0	0	1	0	0	0	16803	1059	37	1	105347	1	TTN	2	179640610	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	42052	179640610	63558763	20	15216											
CPS1	1373	broad.mit.edu	37	chr2	211532931	211532931	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggcttgctttggtgaaggtAttcatacagccttcctaaag	9	14	10	8	0	1	1	1	1	0	0	2	1	2	1	2	3	3	3	2	3	5	7			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:211532931A>T	uc002vee.3	+	34	4156	c.4024A>T	c.(4024-4026)ATT>TTT	p.I1342F	CPS1_uc010fur.2_Missense_Mutation_p.I1348F|CPS1_uc010fus.2_Missense_Mutation_p.I891F	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1342					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGGTGAAGGTATTCATACAGC	0.378													14	56					0	0	0	0	T	211532931	T	T	211532931	3	4	76	1	0	0	0	0	1	0	0	0	3838	449	16	5	4180	5	CPS1	2	211532931	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	31892321	211532931	31666442	21	15217											
TTLL4	9654	broad.mit.edu	37	chr2	219609873	219609873	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaacccctttccaatcatgAgaaagttgtccgaccagccc	12	8	6	15	1	1	1	1	1	0	1	3	3	3	1	6	0	2	1	6	0	3	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:219609873A>G	uc002viy.2	+	6	2073	c.1703A>G	c.(1702-1704)GAG>GGG	p.E568G	TTLL4_uc010zkl.1_Missense_Mutation_p.E403G|TTLL4_uc010fvx.2_Missense_Mutation_p.E568G|TTLL4_uc010zkm.1_5'Flank	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	568					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		TCCAATCATGAGAAAGTTGTC	0.473													30	94					0	0	0	0	G	219609873	G	G	219609873	3	3	76	1	0	0	0	0	1	0	0	0	16797	304	11	5	1717	5	TTLL4	2	219609873	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	8076942	219609873	23589500	22	15218											
CUL3	8452	broad.mit.edu	37	chr2	225365129	225365129	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctggtgggatgttgcactTtggtgtggctgactgagtgg	4	14	18	5	0	0	2	0	2	0	0	0	3	0	3	0	5	2	4	0	5	0	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr2:225365129T>A	uc002vny.2	-	11	1945	c.1561A>T	c.(1561-1563)AAG>TAG	p.K521*	CUL3_uc010zls.1_Nonsense_Mutation_p.K455*|CUL3_uc010fwy.1_Nonsense_Mutation_p.K527*|CUL3_uc002vnz.1_5'UTR	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	521					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ATGTTGCACTTTGGTGTGGCT	0.413													20	105					0	0	0	0	A	225365129	A	A	225365129	4	1	76	1	0	0	0	0	0	1	0	0	4073	1850	64	5	769	5	CUL3	2	225365129	Nonsense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	5755256	225365129	17834244	23	15219											
CNTN6	27255	broad.mit.edu	37	chr3	1363354	1363355	+	Frame_Shift_Ins	INS	-	GA	GA																															ccagtccccgatattagttgINSgagaaggttggacgggagcc																										TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:1363354_1363355insGA	uc003boz.2	+	8	1049_1050	c.782_783insGA	c.(781-783)TGGfs	p.W261fs	CNTN6_uc011asj.1_Frame_Shift_Ins_p.W189fs|CNTN6_uc003bpa.2_Frame_Shift_Ins_p.W261fs	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	261	Ig-like C2-type 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GATATTAGTTGGAGAAGGTTGG	0.416													---	---	---								GA	1363355	GA	GA	1363354	7	5	76	1	0	1	1	0	0	0	0	0	3660	1357	47	0	808	0	CNTN6	3	1363354	Frame_Shift_Ins	INS	-	TCGA-CN-6019-01A-11D-1683-08		1363354	196659076	24	15220											
RFTN1	23180	broad.mit.edu	37	chr3	16475413	16475413	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgctccaggggcgtcttctCccgctcatgggtgggctgca	3	10	15	13	2	3	0	1	0	2	0	5	0	4	0	2	4	2	4	2	4	0	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:16475413C>T	uc003cay.2	-	3	559	c.277G>A	c.(277-279)GAG>AAG	p.E93K	RFTN1_uc010hes.2_Missense_Mutation_p.E57K	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	93						plasma membrane				ovary(3)|central_nervous_system(1)	4						GGCGTCTTCTCCCGCTCATGG	0.632													23	86					0	0	0	0	T	16475413	T	T	16475413	3	4	76	1	0	0	0	0	1	0	0	0	13323	864	30	2	1491	2	RFTN1	3	16475413	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	15112059	16475413	181547017	25	15221											
ARPP21	10777	broad.mit.edu	37	chr3	35730853	35730853	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agacttacacgagtttctgaTtaacacattaaagaataatt	17	13	5	6	1	1	3	0	1	1	2	1	4	1	3	0	0	2	1	0	0	6	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:35730853T>A	uc003cgb.2	+	7	725	c.461T>A	c.(460-462)ATT>AAT	p.I154N	ARPP21_uc003cga.2_Missense_Mutation_p.I154N|ARPP21_uc011axy.1_Missense_Mutation_p.I154N|ARPP21_uc003cgf.2_5'Flank	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	154						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GAGTTTCTGATTAACACATTA	0.343													13	53					0	0	0	0	A	35730853	A	A	35730853	3	1	76	1	0	0	0	0	1	0	0	0	980	1493	52	5	492	5	ARPP21	3	35730853	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	19255440	35730853	162291577	26	15222											
KIF9	64147	broad.mit.edu	37	chr3	47277951	47277951	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acccatgagcaggcggtggcGacactgatccactaggtgct	9	7	13	12	2	0	2	0	2	0	0	1	3	1	2	2	4	2	2	2	4	1	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:47277951G>A	uc010hjp.2	-	19	2687	c.2083C>T	c.(2083-2085)CGC>TGC	p.R695C	KIF9_uc003cqx.2_Missense_Mutation_p.R695C|KIF9_uc003cqy.2_Missense_Mutation_p.R630C|KIF9_uc011bat.1_RNA|uc003cqw.1_Intron	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2	695					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		AGGCGGTGGCGACACTGATCC	0.592													11	31					0	0	0	0	A	47277951	A	A	47277951	3	1	76	1	0	0	0	0	1	0	0	0	8349	1058	37	1	305	1	KIF9	3	47277951	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	11547098	47277951	150744479	27	15223											
EPHA6	285220	broad.mit.edu	37	chr3	96533606	96533606	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctcgcgcagggggcgccccGggacaccccctgcgggccgg	3	2	17	19	6	0	0	0	0	0	0	1	1	0	1	6	5	1	1	6	5	0	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:96533606G>T	uc010how.1	+	1	182	c.139G>T	c.(139-141)GGG>TGG	p.G47W	EPHA6_uc003drp.1_Missense_Mutation_p.G47W	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	Error:Variant_position_missing_in_Q9UF33_after_alignment						integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GGGGCGCCCCGGGACACCCCC	0.627													5	26					1.23904e-05	1.46432e-05	1	0	T	96533606	T	T	96533606	3	4	76	1	0	0	0	0	1	0	0	0	5195	1116	39	3	141	3	EPHA6	3	96533606	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	49255655	96533606	101488824	28	15224											
COL6A6	131873	broad.mit.edu	37	chr3	130283942	130283942	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaggattcttggaagaaagtGtatctgcccttgacataaag	14	11	10	6	0	2	2	0	1	2	1	2	4	2	4	1	2	1	1	1	2	6	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:130283942G>T	uc010htl.2	+	3	797	c.766G>T	c.(766-768)GTA>TTA	p.V256L		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	256	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GGAAGAAAGTGTATCTGCCCT	0.408													32	181					1.08312e-15	1.40806e-15	1	0	T	130283942	T	T	130283942	3	4	76	1	0	0	0	0	1	0	0	0	3718	1377	48	4	776	4	COL6A6	3	130283942	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	33750336	130283942	67738488	29	15225											
COL6A6	131873	broad.mit.edu	37	chr3	130287412	130287412	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acattctgcagcgcattgaaGatgatcttgtttttggaata	11	15	9	6	1	2	3	0	2	2	1	2	4	2	4	0	1	2	3	0	1	3	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:130287412G>C	uc010htl.2	+	5	2396	c.2365G>C	c.(2365-2367)GAT>CAT	p.D789H		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	789	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GCGCATTGAAGATGATCTTGT	0.463													8	85					0	0	0	0	C	130287412	C	C	130287412	3	2	76	1	0	0	0	0	1	0	0	0	3718	942	33	2	2383	2	COL6A6	3	130287412	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	3470	130287412	67735018	30	15226											
TOPBP1	11073	broad.mit.edu	37	chr3	133372361	133372361	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catctcttggcacactcataCttctgacctgtggcgttcat	7	14	7	13	1	4	1	2	1	2	0	5	1	4	1	1	2	1	2	1	2	1	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:133372361C>T	uc003eps.2	-	7	882	c.750G>A	c.(748-750)AAG>AAA	p.K250K		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	250	BRCT 2.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						CACACTCATACTTCTGACCTG	0.348								Other_conserved_DNA_damage_response_genes					7	27					0	0	0	0	T	133372361	T	T	133372361	2	4	76	1	0	0	0	0	0	0	0	1	16436	564	20	4		4	TOPBP1	3	133372361	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08	3084949	133372361	64650069	31	15227											
TF	7018	broad.mit.edu	37	chr3	133495987	133495987	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcagagatgacacagtatGtttggccaaacttcatgaca	13	11	9	8	0	2	3	2	2	0	1	2	4	2	3	1	1	1	3	1	1	2	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:133495987G>A	uc003epu.1	+	21	3695	c.1967G>A	c.(1966-1968)TGT>TAT	p.C656Y	TF_uc011blt.1_Missense_Mutation_p.C529Y|TF_uc003epw.1_Missense_Mutation_p.C95Y|TF_uc003epv.1_Missense_Mutation_p.C656Y	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	656	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	GACACAGTATGTTTGGCCAAA	0.433													5	75					0	0	0	0	A	133495987	A	A	133495987	3	1	76	1	0	0	0	0	1	0	0	0	15851	1377	48	4	2029	4	TF	3	133495987	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	123626	133495987	64526443	32	15228											
IL20RB	53833	broad.mit.edu	37	chr3	136714353	136714353	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtctggaaaatgggccggctGctccagtactcctgttgccc	6	10	12	13	1	1	0	0	0	1	0	3	1	3	1	4	3	3	4	4	3	3	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:136714353G>T	uc003eri.1	+	6	1029	c.780G>T	c.(778-780)CTG>CTT	p.L260L	IL20RB_uc003erj.1_RNA|IL20RB_uc010hud.1_Silent_p.L118L	NM_144717	NP_653318	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta precursor	260	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)	1						TGGGCCGGCTGCTCCAGTACT	0.522													11	472					3.86212e-05	4.44877e-05	1	0	T	136714353	T	T	136714353	2	4	76	1	0	0	0	0	0	0	0	1	7708	1306	46	4		4	IL20RB	3	136714353	Silent	SNP	G	TCGA-CN-6019-01A-11D-1683-08	3218366	136714353	61308077	33	15229											
ZIC4	84107	broad.mit.edu	37	chr3	147109007	147109007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagcgccgctcgcagccctCgaactcgcatctgaagggct	8	6	12	15	5	1	1	0	1	1	0	4	3	1	1	2	1	3	4	2	1	3	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:147109007C>T	uc003ewd.1	-	4	988	c.715G>A	c.(715-717)GAG>AAG	p.E239K	ZIC4_uc003ewc.1_Missense_Mutation_p.E169K|ZIC4_uc011bno.1_Missense_Mutation_p.E289K	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	239	C2H2-type 4.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						TCGCAGCCCTCGAACTCGCAT	0.617													6	38					0	0	0	0	T	147109007	T	T	147109007	3	4	76	1	0	0	0	0	1	0	0	0	17748	893	31	1	297	1	ZIC4	3	147109007	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	10394654	147109007	50913423	34	15230											
ZIC4	84107	broad.mit.edu	37	chr3	147113980	147113980	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggcgcatgtagcggaagAaagcgccaggaccgtggggc	9	4	18	10	4	0	1	0	0	0	1	0	3	0	3	2	5	2	3	2	5	3	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:147113980A>T	uc003ewd.1	-	3	620	c.347T>A	c.(346-348)TTC>TAC	p.F116Y	ZIC4_uc003ewc.1_Missense_Mutation_p.F46Y|ZIC4_uc011bno.1_Missense_Mutation_p.F166Y	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	116						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GTAGCGGAAGAAAGCGCCAGG	0.677													8	72					0	0	0	0	T	147113980	T	T	147113980	3	4	76	1	0	0	0	0	1	0	0	0	17748	246	9	5	669	5	ZIC4	3	147113980	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	4973	147113980	50908450	35	15231											
GPR149	344758	broad.mit.edu	37	chr3	154138953	154138953	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtagtttcttcatagttaaTatcacctcctgttttgtcag	8	18	7	8	0	4	0	3	0	1	0	5	0	5	0	2	1	0	4	2	1	4	8			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr3:154138953T>C	uc003faa.2	-	3	1598	c.1498A>G	c.(1498-1500)ATT>GTT	p.I500V		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	500	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TCATAGTTAATATCACCTCCT	0.398													35	201					0	0	0	0	C	154138953	C	C	154138953	3	2	76	1	0	0	0	0	1	0	0	0	6692	1406	49	5	705	5	GPR149	3	154138953	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	7024973	154138953	43883477	36	15232											
KCNIP4	80333	broad.mit.edu	37	chr4	20852192	20852192	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatcctctgtaaaggatctGaagctctttcttggtaaatt	12	15	7	7	0	4	1	0	1	4	0	5	2	5	2	1	2	1	3	1	2	6	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr4:20852192G>A	uc003gqe.2	-	2	295	c.211C>T	c.(211-213)CAG>TAG	p.Q71*	KCNIP4_uc003gqf.1_Nonsense_Mutation_p.Q67*|KCNIP4_uc003gqg.1_Nonsense_Mutation_p.Q26*|KCNIP4_uc003gqh.1_Nonsense_Mutation_p.Q63*|KCNIP4_uc003gqi.1_Nonsense_Mutation_p.Q26*|KCNIP4_uc010iel.2_Nonsense_Mutation_p.Q68*|KCNIP4_uc003gqd.3_Nonsense_Mutation_p.Q51*	NM_147182	NP_671711	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4 isoform 3	88	EF-hand 1; degenerate.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)				TAAAGGATCTGAAGCTCTTTC	0.458													16	79					0	0	0	0	A	20852192	A	A	20852192	4	1	76	1	0	0	0	0	0	1	0	0	8081	1299	45	2	518	2	KCNIP4	4	20852192	Nonsense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08		20852192	170302084	37	15233											
GABRG1	2565	broad.mit.edu	37	chr4	46043265	46043265	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggatccaggatggagaccagGagtcatctgagcacaataat	14	7	12	8	0	2	2	1	1	1	1	3	6	3	5	2	4	1	1	2	4	2	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr4:46043265G>T	uc003gxb.2	-	9	1290	c.1138C>A	c.(1138-1140)CCT>ACT	p.P380T		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	380	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TGGAGACCAGGAGTCATCTGA	0.393													5	24					8.12818e-05	9.24581e-05	1	0	T	46043265	T	T	46043265	3	4	76	1	0	0	0	0	1	0	0	0	6205	1174	41	2	263	2	GABRG1	4	46043265	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	25191073	46043265	145111011	38	15234											
CHIC2	26511	broad.mit.edu	37	chr4	54915177	54915177	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacctaatgtgcagcagcaaCaaaggcagccacaaagtagc	17	4	9	11	0	0	0	0	0	0	0	0	0	0	0	2	1	7	5	2	1	6	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr4:54915177C>A	uc003haj.1	-	3	596	c.275G>T	c.(274-276)TGT>TTT	p.C92F	PDGFRA_uc003haa.2_Intron	NM_012110	NP_036242	Q9UKJ5	CHIC2_HUMAN	cysteine-rich hydrophobic domain 2	92	CHIC motif (Cys-rich).			CGCLCCCC->SGSLSSSS: Loss of palmitoylation. Abolishes membrane association.		plasma membrane	protein binding			central_nervous_system(1)	1	all_cancers(7;0.0193)|all_neural(26;0.0209)|Lung NSC(11;0.0281)|Glioma(25;0.08)		LUSC - Lung squamous cell carcinoma(32;0.00216)			GCAGCAGCAACAAAGGCAGCC	0.373			T	ETV6	AML								5	11					0.000602214	0.000660259	1	0	A	54915177	A	A	54915177	3	1	76	1	0	0	0	0	1	0	0	0	3359	478	17	4	238	4	CHIC2	4	54915177	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	8871912	54915177	136239099	39	15235											
C4orf21	55345	broad.mit.edu	37	chr4	113468532	113468532	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggaggtagctgtttgggaTccccaacaagaatcagcttt	11	11	11	8	0	1	1	1	0	0	1	2	3	2	3	2	3	3	4	2	3	5	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr4:113468532T>G	uc003iau.2	-	24	5718	c.5507A>C	c.(5506-5508)GAT>GCT	p.D1836A	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Missense_Mutation_p.D294A	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	658						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		CTGTTTGGGATCCCCAACAAG	0.358													3	19					0	0	0	0	G	113468532	G	G	113468532	3	3	76	1	0	0	0	0	1	0	0	0	2264	1435	50	5	827	5	C4orf21	4	113468532	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	58553355	113468532	77685744	40	15236											
PRDM5	11107	broad.mit.edu	37	chr4	121742406	121742406	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcataatttgctgttcttccTcctcagcctccatgtcacta	7	16	4	14	0	4	0	3	0	1	0	7	0	7	0	4	0	2	2	4	0	2	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr4:121742406T>A	uc003idn.2	-	4	645	c.395A>T	c.(394-396)GAG>GTG	p.E132V	PRDM5_uc003ido.2_Missense_Mutation_p.E132V|PRDM5_uc010ine.2_Missense_Mutation_p.E132V|PRDM5_uc010inf.2_Missense_Mutation_p.E132V	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	132					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						CTGTTCTTCCTCCTCAGCCTC	0.403													28	94					0	0	0	0	A	121742406	A	A	121742406	3	1	76	1	0	0	0	0	1	0	0	0	12522	1551	54	5	1549	5	PRDM5	4	121742406	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	8273874	121742406	69411870	41	15237											
FGA	2243	broad.mit.edu	37	chr4	155505421	155505421	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agcccccagggtagtagattCcattgagattggctgcttgg	8	11	13	9	0	0	2	0	1	0	2	1	3	1	2	3	3	2	4	3	3	2	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr4:155505421C>G	uc003iod.1	-	6	2514	c.2456G>C	c.(2455-2457)GGA>GCA	p.G819A		NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	819	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GTAGTAGATTCCATTGAGATT	0.493													26	85					0	0	0	0	G	155505421	G	G	155505421	3	3	76	1	0	0	0	0	1	0	0	0	5862	855	30	2	148	2	FGA	4	155505421	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	33763015	155505421	35648855	42	15238											
FSTL5	56884	broad.mit.edu	37	chr4	162697070	162697070	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctacaagtccattactgtctGcatcaaaatatttaaacatt	15	14	3	9	0	2	0	1	0	1	0	3	0	3	0	1	0	4	1	1	0	8	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr4:162697070G>T	uc003iqh.2	-	5	1002	c.566C>A	c.(565-567)GCA>GAA	p.A189E	FSTL5_uc003iqi.2_Missense_Mutation_p.A188E|FSTL5_uc010iqv.2_Missense_Mutation_p.A188E	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	189	1 (Potential).|EF-hand 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATTACTGTCTGCATCAAAATA	0.294													10	50					5.50884e-06	6.553e-06	1	0	T	162697070	T	T	162697070	3	4	76	1	0	0	0	0	1	0	0	0	6114	1319	46	4	2025	4	FSTL5	4	162697070	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	7191649	162697070	28457206	43	15239											
STOX2	56977	broad.mit.edu	37	chr4	184938290	184938290	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcaagcattgttgaaagtaaCcgtcgtcagaaccccgcttt	11	11	8	11	3	2	2	2	1	0	1	3	2	2	2	3	0	3	4	3	0	4	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr4:184938290C>T	uc003ivz.1	+	4	4069	c.2634C>T	c.(2632-2634)AAC>AAT	p.N878N	uc003iwb.1_5'Flank|STOX2_uc003iwa.1_3'UTR	NM_020225	NP_064610	Q9P2F5	STOX2_HUMAN	storkhead box 2	878					embryo development|maternal placenta development						0		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		TTGAAAGTAACCGTCGTCAGA	0.498													4	14					0	0	0	0	T	184938290	T	T	184938290	2	4	76	1	0	0	0	0	0	0	0	1	15386	506	18	4		4	STOX2	4	184938290	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08	22241220	184938290	6215986	44	15240											
FBXL7	23194	broad.mit.edu	37	chr5	15928334	15928334	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggacccgcggctctggAggactatccgcctgacgggc	5	6	15	15	4	1	1	0	1	1	0	2	4	2	4	4	5	0	1	4	5	1	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr5:15928334A>T	uc003jfn.1	+	3	944	c.463A>T	c.(463-465)AGG>TGG	p.R155W		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	155	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						GCGGCTCTGGAGGACTATCCG	0.657													4	8					0	0	0	0	T	15928334	T	T	15928334	3	4	76	1	0	0	0	0	1	0	0	0	5756	295	11	5	473	5	FBXL7	5	15928334	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08		15928334	164986926	45	15241											
ADAMTS12	81792	broad.mit.edu	37	chr5	33576173	33576173	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttacctcgctccagtttcCgacgatccagtgtgcagagc	7	11	9	14	3	1	1	0	0	1	1	5	3	4	1	4	0	3	3	4	0	1	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr5:33576173C>T	uc003jia.1	-	19	4121	c.3958G>A	c.(3958-3960)GGA>AGA	p.G1320R	ADAMTS12_uc010iuq.1_Missense_Mutation_p.G1235R	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1320	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CTCCAGTTTCCGACGATCCAG	0.448										HNSCC(64;0.19)			18	60					0	0	0	0	T	33576173	T	T	33576173	3	4	76	1	0	0	0	0	1	0	0	0	257	661	23	1	850	1	ADAMTS12	5	33576173	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	17647839	33576173	147339087	46	15242											
HSD17B4	3295	broad.mit.edu	37	chr5	118810155	118810155	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggatgcttttggaagaataGgtgatgtttctttgtgttat	8	19	12	2	0	1	2	0	1	1	1	1	4	1	4	0	3	1	3	0	3	4	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr5:118810155G>A	uc003ksj.2	+	4	403	c.280G>A	c.(280-282)GAT>AAT	p.D94N	HSD17B4_uc011cwg.1_Missense_Mutation_p.D70N|HSD17B4_uc011cwh.1_Missense_Mutation_p.D76N|HSD17B4_uc011cwi.1_Missense_Mutation_p.D119N|HSD17B4_uc003ksk.3_5'UTR|HSD17B4_uc011cwj.1_5'Flank|HSD17B4_uc010jcn.1_5'Flank	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	94	(3R)-hydroxyacyl-CoA dehydrogenase.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	TGGAAGAATAGGTGATGTTTC	0.388													12	82					0	0	0	0	A	118810155	A	A	118810155	3	1	76	1	0	0	0	0	1	0	0	0	7425	1014	35	4	294	4	HSD17B4	5	118810155	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	85233982	118810155	62105105	47	15243											
TIMD4	91937	broad.mit.edu	37	chr5	156349204	156349204	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatgggcatttcattcttCattgacatgggtattccatc	9	15	9	8	0	3	2	2	1	1	1	5	3	4	2	1	2	0	2	1	2	1	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr5:156349204C>A	uc003lwh.2	-	7	975	c.918G>T	c.(916-918)ATG>ATT	p.M306I	TIMD4_uc010jii.2_Missense_Mutation_p.M278I|TIMD4_uc003lwg.2_Missense_Mutation_p.M8I	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	306	Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTCATTCTTCATTGACATGG	0.502													5	28					3.59834e-05	4.17132e-05	1	0	A	156349204	A	A	156349204	3	1	76	1	0	0	0	0	1	0	0	0	15969	826	29	2	230	2	TIMD4	5	156349204	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	37539049	156349204	24566056	48	15244											
STK10	6793	broad.mit.edu	37	chr5	171517330	171517330	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatccaccacaaatttgcGtgtccgcttgagggtttttt	8	14	8	11	2	0	1	0	1	0	0	2	1	2	1	4	1	1	2	4	1	1	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr5:171517330G>A	uc003mbo.1	-	10	1891	c.1591C>T	c.(1591-1593)CGC>TGC	p.R531C		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	531							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ACAAATTTGCGTGTCCGCTTG	0.502													7	188					0	0	0	0	A	171517330	A	A	171517330	3	1	76	1	0	0	0	0	1	0	0	0	15352	1145	40	1	1355	1	STK10	5	171517330	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	15168126	171517330	9397930	49	15245											
HIST1H1B	3009	broad.mit.edu	37	chr6	27834730	27834730	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccttcggcttaactgccttgGgcttggcaggactcttggtt	4	14	12	11	1	1	0	0	0	1	0	2	1	1	1	2	5	2	4	2	5	1	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:27834730G>T	uc003njx.2	-	1	630	c.578C>A	c.(577-579)CCC>CAC	p.P193H		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	193					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						AACTGCCTTGGGCTTGGCAGG	0.572													19	77					1.2644e-06	1.52398e-06	1	0	T	27834730	T	T	27834730	3	4	76	1	0	0	0	0	1	0	0	0	7162	1232	43	4	106	4	HIST1H1B	6	27834730	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08		27834730	143280337	50	15246											
PPP1R10	5514	broad.mit.edu	37	chr6	30574254	30574254	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagtcttaccagtggaacGgaacttggcatgactgggtg	9	9	14	9	1	1	1	0	1	1	0	1	3	1	3	2	4	3	1	2	4	3	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:30574254G>A	uc003nqn.1	-	8	1177	c.625C>T	c.(625-627)CGT>TGT	p.R209C	PPP1R10_uc010jsc.1_5'UTR	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	209	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						CCAGTGGAACGGAACTTGGCA	0.567													12	78					0	0	0	0	A	30574254	A	A	30574254	3	1	76	1	0	0	0	0	1	0	0	0	12412	1116	39	1	2249	1	PPP1R10	6	30574254	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	2739524	30574254	140540813	51	15247											
VPS52	6293	broad.mit.edu	37	chr6	33236966	33236966	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcccaacatctgctccattcGctgtagggagggtagatgtt	8	12	11	10	1	1	1	0	0	1	1	4	2	3	2	2	2	2	5	2	2	3	4	rs148755872	byFrequency	TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:33236966G>A	uc003odm.1	-	6	583	c.373C>T	c.(373-375)CGA>TGA	p.R125*	VPS52_uc003odn.1_5'UTR|VPS52_uc003odo.1_Nonsense_Mutation_p.R50*|VPS52_uc011dqy.1_5'UTR|VPS52_uc011dqz.1_5'UTR|RPS18_uc003odp.1_5'Flank|RPS18_uc010jum.1_5'Flank	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	125	Potential.				protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						TGCTCCATTCGCTGTAGGGAG	0.498													7	99					0	0	0	0	A	33236966	A	A	33236966	4	1	76	1	0	0	0	0	0	1	0	0	17282	1101	38	1	1858	1	VPS52	6	33236966	Nonsense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	2662712	33236966	137878101	52	15248											
PKHD1	5314	broad.mit.edu	37	chr6	51923195	51923195	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtaagtggtgaccacatcagGattcagccaggtgttgtgaa	11	10	13	7	0	2	2	2	2	0	0	2	3	2	3	2	3	1	2	2	3	2	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:51923195G>T	uc003pah.1	-	16	1714	c.1438C>A	c.(1438-1440)CCT>ACT	p.P480T	PKHD1_uc003pai.2_Missense_Mutation_p.P480T	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	480	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					ACCACATCAGGATTCAGCCAG	0.552													29	94					3.65163e-15	4.71345e-15	1	0	T	51923195	T	T	51923195	3	4	76	1	0	0	0	0	1	0	0	0	12026	1174	41	2	11033	2	PKHD1	6	51923195	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	18686229	51923195	119191872	53	15249											
PHF3	23469	broad.mit.edu	37	chr6	64416739	64416739	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttaccaaagcctatccagtAtctggctccccagaatacct	11	10	6	14	0	1	1	0	0	1	1	3	1	3	1	6	1	3	3	6	1	6	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:64416739A>G	uc003pep.1	+	12	3710	c.3684A>G	c.(3682-3684)GTA>GTG	p.V1228V	PHF3_uc010kah.1_Silent_p.V1042V|PHF3_uc003pen.2_Silent_p.V1140V|PHF3_uc011dxs.1_Silent_p.V497V	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1228					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CCTATCCAGTATCTGGCTCCC	0.398													29	102					0	0	0	0	G	64416739	G	G	64416739	2	3	76	1	0	0	0	0	0	0	0	1	11891	436	16	5		5	PHF3	6	64416739	Silent	SNP	A	TCGA-CN-6019-01A-11D-1683-08	12493544	64416739	106698328	54	15250											
EYS	346007	broad.mit.edu	37	chr6	66094289	66094290	+	Missense_Mutation	DNP	CC	AA	AA																															aattacttactttgaatcttCcaattatattgaaacaccat																										TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:66094289_66094290CC>AA	uc011dxu.1	-	8	1826_1827	c.1288_1289GG>TT	c.(1288-1290)GGA>TTA	p.G430L	EYS_uc003peq.2_Missense_Mutation_p.G430L|EYS_uc003per.1_Missense_Mutation_p.G430L	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	430					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TTTGAATCTTCCAATTATATTG	0.307													5	42					0	0	0	0	AA	66094290	AA	AA	66094289	3	1	76	1	0	0	0	0	1	0	0	0	5357	855	30	2	8251	2	EYS	6	66094289	Missense_Mutation	DNP	CC	TCGA-CN-6019-01A-11D-1683-08	1677550	66094289	105020778	55	15251											
SLC16A10	117247	broad.mit.edu	37	chr6	111409193	111409193	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgctggcggccatgtggTgcaacgggtcggtgttcggc	4	10	18	9	4	0	1	0	1	0	0	2	1	0	1	1	6	3	3	1	6	1	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:111409193T>C	uc003pus.2	+	1	413	c.238T>C	c.(238-240)TGC>CGC	p.C80R	SLC16A10_uc003pur.3_Missense_Mutation_p.C80R	NM_018593	NP_061063	Q8TF71	MOT10_HUMAN	solute carrier family 16, member 10	80	Helical; (Potential).				aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity				0		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		GGCCATGTGGTGCAACGGGTC	0.662													6	20					0	0	0	0	C	111409193	C	C	111409193	3	2	76	1	0	0	0	0	1	0	0	0	14468	1696	59	5	240	5	SLC16A10	6	111409193	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	45314904	111409193	59705874	56	15252											
FABP7	2173	broad.mit.edu	37	chr6	123101594	123101594	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgaaaccactgcagatGatagaaactgtaaggtgaga	16	9	11	5	0	0	6	0	4	0	3	0	7	0	6	1	1	3	2	1	1	4	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:123101594G>T	uc003pzf.2	+	2	526	c.232G>T	c.(232-234)GAT>TAT	p.D78Y	FABP7_uc003pzd.2_Missense_Mutation_p.D78Y|FABP7_uc003pze.1_Missense_Mutation_p.D78Y	NM_001446	NP_001437	O15540	FABP7_HUMAN	fatty acid binding protein 7, brain	78					negative regulation of cell proliferation	cytoplasm	lipid binding|transporter activity				0				GBM - Glioblastoma multiforme(226;0.226)	Alpha-Linolenic Acid(DB00132)|gamma-Homolinolenic acid(DB00154)|Icosapent(DB00159)	CACTGCAGATGATAGAAACTG	0.413													3	29					0.004672	0.00494363	1	0	T	123101594	T	T	123101594	3	4	76	1	0	0	0	0	1	0	0	0	5390	1290	45	2	238	2	FABP7	6	123101594	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	11692401	123101594	48013473	57	15253											
EPB41L2	2037	broad.mit.edu	37	chr6	131191188	131191188	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatctctttaccattcatttCttctgtgattactctttcgt	6	22	3	10	1	5	1	1	1	4	0	7	1	5	1	1	0	2	0	1	0	3	8			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:131191188C>T	uc003qch.2	-	15	2304	c.2122G>A	c.(2122-2124)GAA>AAA	p.E708K	EPB41L2_uc003qce.1_Missense_Mutation_p.E86K|EPB41L2_uc003qcf.1_Intron|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Missense_Mutation_p.E638K|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Missense_Mutation_p.E638K|EPB41L2_uc003qcd.1_5'Flank|EPB41L2_uc003qcj.1_Missense_Mutation_p.E105K	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	708					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CCATTCATTTCTTCTGTGATT	0.458													5	64					0	0	0	0	T	131191188	T	T	131191188	3	4	76	1	0	0	0	0	1	0	0	0	5177	922	32	2	915	2	EPB41L2	6	131191188	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	8089594	131191188	39923879	58	15254											
EYA4	2070	broad.mit.edu	37	chr6	133783834	133783834	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccattacagagtggctGcctcagttacagcccagggt	8	9	11	13	0	1	1	1	0	0	1	2	1	2	1	4	2	4	2	4	2	2	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:133783834G>T	uc003qec.3	+	9	1114	c.656G>T	c.(655-657)TGC>TTC	p.C219F	EYA4_uc011ecq.1_Missense_Mutation_p.C165F|EYA4_uc011ecr.1_Missense_Mutation_p.C165F|EYA4_uc003qed.3_Missense_Mutation_p.C219F|EYA4_uc003qee.3_Missense_Mutation_p.C196F|EYA4_uc011ecs.1_Missense_Mutation_p.C219F|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	219					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CAGAGTGGCTGCCTCAGTTAC	0.468													13	46					6.49762e-13	8.2697e-13	1	0	T	133783834	T	T	133783834	3	4	76	1	0	0	0	0	1	0	0	0	5356	1319	46	4	686	4	EYA4	6	133783834	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	2592646	133783834	37331233	59	15255											
PLEKHG1	57480	broad.mit.edu	37	chr6	151152187	151152187	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggaggagatgactccctttgGgtcatccatagagttgacta	10	11	12	8	0	1	4	1	2	0	2	3	6	3	5	2	3	0	1	2	3	2	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:151152187G>C	uc003qny.1	+	16	2252	c.1940G>C	c.(1939-1941)GGG>GCG	p.G647A	PLEKHG1_uc011eel.1_Missense_Mutation_p.G687A|PLEKHG1_uc011eem.1_Missense_Mutation_p.G706A|PLEKHG1_uc003qnz.2_Missense_Mutation_p.G647A	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	647					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		ACTCCCTTTGGGTCATCCATA	0.448													7	34					0	0	0	0	C	151152187	C	C	151152187	3	2	76	1	0	0	0	0	1	0	0	0	12123	1232	43	4	1994	4	PLEKHG1	6	151152187	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	17368353	151152187	19962880	60	15256											
SYNE1	23345	broad.mit.edu	37	chr6	152501328	152501328	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctccattctgagaaactttGctttccatttgagtcaacca	10	15	5	11	0	3	2	1	2	2	1	5	3	4	2	3	0	3	1	3	0	2	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:152501328G>T	uc010kiw.2	-	129	24005	c.23403C>A	c.(23401-23403)AGC>AGA	p.S7801R	SYNE1_uc010kiv.2_Missense_Mutation_p.S2325R|SYNE1_uc003qos.3_Missense_Mutation_p.S2325R|SYNE1_uc003qot.3_Missense_Mutation_p.S7730R|SYNE1_uc003qou.3_Missense_Mutation_p.S7801R|SYNE1_uc003qop.3_5'Flank|SYNE1_uc011eez.1_Missense_Mutation_p.S3R|SYNE1_uc003qoq.3_Missense_Mutation_p.S3R|SYNE1_uc003qor.3_Missense_Mutation_p.S701R	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7801	Spectrin 27.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAGAAACTTTGCTTTCCATTT	0.403										HNSCC(10;0.0054)			18	75					1.99824e-07	2.42453e-07	1	0	T	152501328	T	T	152501328	3	4	76	1	0	0	0	0	1	0	0	0	15511	1310	46	4	3135	4	SYNE1	6	152501328	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	1349141	152501328	18613739	61	15257											
SYNE1	23345	broad.mit.edu	37	chr6	152529258	152529258	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actggcgaatctggctgtcaAtgatcccccgcctctgctgg	6	10	11	14	2	3	1	1	1	2	0	4	2	4	1	3	3	1	2	3	3	2	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr6:152529258A>T	uc010kiw.2	-	125	23275	c.22673T>A	c.(22672-22674)ATT>AAT	p.I7558N	SYNE1_uc010kiv.2_Missense_Mutation_p.I2082N|SYNE1_uc003qos.3_Missense_Mutation_p.I2082N|SYNE1_uc003qot.3_Missense_Mutation_p.I7487N|SYNE1_uc003qou.3_Missense_Mutation_p.I7558N|SYNE1_uc003qor.3_Missense_Mutation_p.I458N	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7558	HAT 11.|Cytoplasmic (Potential).|Spectrin 25.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGGCTGTCAATGATCCCCCG	0.502										HNSCC(10;0.0054)			4	39					0	0	0	0	T	152529258	T	T	152529258	3	4	76	1	0	0	0	0	1	0	0	0	15511	101	4	5	3881	5	SYNE1	6	152529258	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	27930	152529258	18585809	62	15258											
NFE2L3	9603	broad.mit.edu	37	chr7	26225151	26225151	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatttagaagatgatgtatgTaacttgcaagcaaagaagga	18	10	10	3	0	0	4	0	1	0	3	0	5	0	5	0	1	3	4	0	1	8	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:26225151T>C	uc003sxq.2	+	4	2105	c.1833T>C	c.(1831-1833)TGT>TGC	p.C611C		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	611	Leucine-zipper.				transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						ATGATGTATGTAACTTGCAAG	0.353													9	58					0	0	0	0	C	26225151	C	C	26225151	2	2	76	1	0	0	0	0	0	0	0	1	10423	1644	57	5		5	NFE2L3	7	26225151	Silent	SNP	T	TCGA-CN-6019-01A-11D-1683-08		26225151	132913512	63	15259											
MLXIPL	51085	broad.mit.edu	37	chr7	73008629	73008629	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggagagcgggcagagagcaGtactggtccagccaggccag	10	3	17	11	2	0	2	0	0	0	2	1	4	1	2	3	4	4	3	3	4	1	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:73008629G>A	uc003tyn.1	-	16	2463	c.2415C>T	c.(2413-2415)TAC>TAT	p.Y805Y	MLXIPL_uc003tyj.1_Silent_p.Y184Y|MLXIPL_uc003tyk.1_Silent_p.Y784Y|MLXIPL_uc003tyl.1_Silent_p.Y803Y|MLXIPL_uc003tym.1_Silent_p.Y786Y|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Silent_p.Y711Y	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	805					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				GCAGAGAGCAGTACTGGTCCA	0.627													14	56					0	0	0	0	A	73008629	A	A	73008629	2	1	76	1	0	0	0	0	0	0	0	1	9690	1024	36	4		4	MLXIPL	7	73008629	Silent	SNP	G	TCGA-CN-6019-01A-11D-1683-08	46783478	73008629	86130034	64	15260											
ABHD11	83451	broad.mit.edu	37	chr7	73151996	73151996	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtcctgcaggtcctggcTcatgatctcgtagctcatgt	7	12	11	11	1	3	1	2	1	1	0	6	1	5	1	2	3	2	4	2	3	2	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:73151996T>A	uc003tzb.2	-	3	415	c.358A>T	c.(358-360)AGC>TGC	p.S120C	RFC2_uc011kfa.1_Intron|ABHD11_uc011kfb.1_Missense_Mutation_p.S120C|ABHD11_uc003tzc.2_Missense_Mutation_p.S113C|ABHD11_uc003tza.2_Missense_Mutation_p.S7C	NM_148912	NP_683710	Q8NFV4	ABHDB_HUMAN	abhydrolase domain containing 11 isoform 1	120							hydrolase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				AGGTCCTGGCTCATGATCTCG	0.637													4	31					0	0	0	0	A	73151996	A	A	73151996	3	1	76	1	0	0	0	0	1	0	0	0	75	1551	54	5	605	5	ABHD11	7	73151996	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	143367	73151996	85986667	65	15261											
FZD1	8321	broad.mit.edu	37	chr7	90895658	90895658	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taacaacgtggacgcgctgcGtggcttcgtgctggcgcccc	5	8	14	14	6	0	0	0	0	0	0	1	1	0	1	2	3	4	3	2	3	2	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:90895658G>T	uc003ula.2	+	1	1876	c.1463G>T	c.(1462-1464)CGT>CTT	p.R488L		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	488	Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			GACGCGCTGCGTGGCTTCGTG	0.622													32	165					6.00712e-18	7.86544e-18	1	0	T	90895658	T	T	90895658	3	4	76	1	0	0	0	0	1	0	0	0	6162	1145	40	3	1465	3	FZD1	7	90895658	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	17743662	90895658	68243005	66	15262											
CCDC132	55610	broad.mit.edu	37	chr7	92905556	92905556	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgttcttggttatgtggAactatgtgcaggaaacacag	11	13	12	5	0	1	0	0	0	1	0	1	2	1	2	0	3	3	4	0	3	4	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:92905556A>T	uc003umo.2	+	12	1009	c.881A>T	c.(880-882)GAA>GTA	p.E294V	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.E264V|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Missense_Mutation_p.E294V	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	294											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			GGTTATGTGGAACTATGTGCA	0.378													29	90					0	0	0	0	T	92905556	T	T	92905556	3	4	76	1	0	0	0	0	1	0	0	0	2779	246	9	5	927	5	CCDC132	7	92905556	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	2009898	92905556	66233107	67	15263											
COL1A2	1278	broad.mit.edu	37	chr7	94058730	94058730	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcacttacactgttcttgtAgatggctgctctgtaagtaa	9	16	8	8	0	3	1	1	0	2	1	3	1	3	1	0	1	2	6	0	1	4	7			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:94058730A>G	uc003ung.1	+	51	4413	c.3942A>G	c.(3940-3942)GTA>GTG	p.V1314V	COL1A2_uc011kib.1_Silent_p.V166V	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1314	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CTGTTCTTGTAGATGGCTGCT	0.478										HNSCC(75;0.22)			7	59					0	0	0	0	G	94058730	G	G	94058730	2	3	76	1	0	0	0	0	0	0	0	1	3693	407	15	5		5	COL1A2	7	94058730	Silent	SNP	A	TCGA-CN-6019-01A-11D-1683-08	1153174	94058730	65079933	68	15264											
RELN	5649	broad.mit.edu	37	chr7	103207056	103207056	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagtaacttaccatgttgcGgttgccaccatcgaaatgcc	10	10	9	12	2	0	0	0	0	0	0	1	1	0	0	4	1	5	4	4	1	3	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:103207056G>C	uc003vca.2	-	32	4899	c.4739C>G	c.(4738-4740)CCG>CGG	p.P1580R	RELN_uc010liz.2_Missense_Mutation_p.P1580R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1580					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACCATGTTGCGGTTGCCACCA	0.483													14	43					0	0	0	0	C	103207056	C	C	103207056	3	2	76	1	0	0	0	0	1	0	0	0	13285	1116	39	3	5779	3	RELN	7	103207056	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	9148326	103207056	55931607	69	15265											
PAX4	5078	broad.mit.edu	37	chr7	127251714	127251714	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcagggctgctgtgggcAcactgccaggggactgctaa	8	6	16	11	0	0	0	0	0	0	0	0	1	0	1	1	5	3	5	1	5	1	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:127251714A>G	uc010lld.1	-	8	970	c.764T>C	c.(763-765)GTG>GCG	p.V255A	PAX4_uc003vmf.2_Missense_Mutation_p.V253A|PAX4_uc003vmg.1_Missense_Mutation_p.V255A	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	263					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGCTGTGGGCACACTGCCAGG	0.582													15	71					0	0	0	0	G	127251714	G	G	127251714	3	3	76	1	0	0	0	0	1	0	0	0	11535	159	6	5	275	5	PAX4	7	127251714	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	24044658	127251714	31886949	70	15266											
CREB3L2	64764	broad.mit.edu	37	chr7	137567275	137567275	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgacaccctgagcagggagGaacctctatcccagcccccc	9	5	9	18	0	1	2	0	2	1	0	2	4	2	4	6	2	3	1	6	2	2	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:137567275G>A	uc003vtw.2	-	11	1765	c.1370C>T	c.(1369-1371)TCC>TTC	p.S457F	CREB3L2_uc003vtv.2_Missense_Mutation_p.S394F	NM_194071	NP_919047	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like	457	Lumenal (Potential).				chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	soft_tissue(158)|upper_aerodigestive_tract(1)|ovary(1)	160						GAGCAGGGAGGAACCTCTATC	0.582			T	FUS	fibromyxoid sarcoma								6	42					0	0	0	0	A	137567275	A	A	137567275	3	1	76	1	0	0	0	0	1	0	0	0	3872	1174	41	2	200	2	CREB3L2	7	137567275	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	10315561	137567275	21571388	71	15267											
OR6V1	346517	broad.mit.edu	37	chr7	142749510	142749510	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtgagctgcaggcccttCtgtatggccccttcctcatg	4	13	11	13	0	2	1	1	1	1	0	3	1	3	1	4	3	2	3	4	3	1	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:142749510C>T	uc011ksv.1	+	1	73	c.73C>T	c.(73-75)CTG>TTG	p.L25L		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	25	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					GCAGGCCCTTCTGTATGGCCC	0.512													4	154					0	0	0	0	T	142749510	T	T	142749510	2	4	76	1	0	0	0	0	0	0	0	1	11265	912	32	2		2	OR6V1	7	142749510	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08	5182235	142749510	16389153	72	15268											
C7orf33	202865	broad.mit.edu	37	chr7	148288032	148288032	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaaaatgcaagtggaagtTcaaagcctcagccttgaaga	15	7	10	9	0	2	2	2	1	0	1	2	3	2	3	3	1	3	2	3	1	6	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr7:148288032T>G	uc003wew.2	+	1	376	c.15T>G	c.(13-15)GTT>GTG	p.V5V		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	5										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			AAGTGGAAGTTCAAAGCCTCA	0.537													10	37					0	0	0	0	G	148288032	G	G	148288032	2	3	76	1	0	0	0	0	0	0	0	1	2399	1770	62	5		5	C7orf33	7	148288032	Silent	SNP	T	TCGA-CN-6019-01A-11D-1683-08	5538522	148288032	10850631	73	15269											
CLVS1	157807	broad.mit.edu	37	chr8	62212794	62212794	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggaaaaccgagaccattaCggcaggaagattcttttgct	12	10	10	9	2	1	2	0	0	1	2	1	5	1	4	2	3	3	2	2	3	4	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr8:62212794C>A	uc003xuh.2	+	2	732	c.408C>A	c.(406-408)TAC>TAA	p.Y136*	CLVS1_uc003xug.2_Nonsense_Mutation_p.Y136*|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Nonsense_Mutation_p.Y136*	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	136	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						GAGACCATTACGGCAGGAAGA	0.443													9	28					2.17888e-05	2.54202e-05	1	0	A	62212794	A	A	62212794	4	1	76	1	0	0	0	0	0	1	0	0	3586	547	19	3	410	3	CLVS1	8	62212794	Nonsense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08		62212794	84151228	74	15270											
NCOA2	10499	broad.mit.edu	37	chr8	71036232	71036232	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacctgtgttggtcgccaTggacacattgatgttcatgt	7	13	11	10	1	1	1	1	1	0	0	2	2	1	2	3	2	0	2	3	2	0	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr8:71036232T>A	uc003xyn.1	-	21	4342	c.4180A>T	c.(4180-4182)ATG>TTG	p.M1394L	NCOA2_uc011lfb.1_Missense_Mutation_p.M482L	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1394					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TTGGTCGCCATGGACACATTG	0.517			T	RUNXBP2	AML								6	30					0	0	0	0	A	71036232	A	A	71036232	3	1	76	1	0	0	0	0	1	0	0	0	10283	1464	51	5	226	5	NCOA2	8	71036232	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	8823438	71036232	75327790	75	15271											
C8orf37	157657	broad.mit.edu	37	chr8	96259940	96259940	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactggcaggcatatgcccGtgttcctttcttctttatca	7	15	7	12	1	3	0	1	0	2	0	4	0	4	0	2	2	1	3	2	2	2	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr8:96259940G>A	uc003yho.1	-	6	549	c.529C>T	c.(529-531)CGG>TGG	p.R177W		NM_177965	NP_808880	Q96NL8	CH037_HUMAN	hypothetical protein LOC157657	177											0	Breast(36;3.41e-05)					GCATATGCCCGTGTTCCTTTC	0.393													7	45					0	0	0	0	A	96259940	A	A	96259940	3	1	76	1	0	0	0	0	1	0	0	0	2435	1144	40	1	98	1	C8orf37	8	96259940	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	25223708	96259940	50104082	76	15272											
CSMD3	114788	broad.mit.edu	37	chr8	114449052	114449052	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccagggtttggattcctttGctcggctttcccctttgcgg	2	15	11	13	2	0	0	0	0	0	0	3	1	2	1	4	4	2	3	4	4	0	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr8:114449052G>C	uc003ynu.2	-	1	191	c.32C>G	c.(31-33)GCA>GGA	p.A11G	CSMD3_uc011lhx.1_Missense_Mutation_p.A11G|CSMD3_uc010mcx.1_Missense_Mutation_p.A11G|CSMD3_uc003ynx.3_Missense_Mutation_p.A11G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	11	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGATTCCTTTGCTCGGCTTTC	0.517										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)	OREG0018933	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	79					0	0	0	0	C	114449052	C	C	114449052	3	2	76	1	0	0	0	0	1	0	0	0	3963	1319	46	4	11437	4	CSMD3	8	114449052	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	18189112	114449052	31914970	77	15273											
ENPP2	5168	broad.mit.edu	37	chr8	120595959	120595959	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attaaatgagtgacttaccaCacataacattgtaaagttca	17	12	5	7	0	1	2	1	2	0	0	1	2	1	2	1	0	2	2	1	0	6	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr8:120595959C>G	uc003yot.1	-	17	1627	c.1541G>C	c.(1540-1542)TGT>TCT	p.C514S	ENPP2_uc011lic.1_Missense_Mutation_p.C31S|ENPP2_uc003yor.1_Missense_Mutation_p.C153S|ENPP2_uc003yos.1_Missense_Mutation_p.C566S|ENPP2_uc010mdd.1_Missense_Mutation_p.C514S	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	514					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGACTTACCACACATAACATT	0.318													10	63					0	0	0	0	G	120595959	G	G	120595959	3	3	76	1	0	0	0	0	1	0	0	0	5154	478	17	4	1165	4	ENPP2	8	120595959	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	6146907	120595959	25768063	78	15274											
COL22A1	169044	broad.mit.edu	37	chr8	139649017	139649017	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcccaacctcaccatctgCaccacgttctccttgacttc	7	11	4	19	1	3	1	1	1	2	0	5	1	3	1	5	0	3	2	5	0	1	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr8:139649017C>T	uc003yvd.2	-	48	3970	c.3523G>A	c.(3523-3525)GCA>ACA	p.A1175T	COL22A1_uc011ljo.1_Missense_Mutation_p.A455T	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1175	Pro-rich.|Gly-rich.|Collagen-like 11.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCACCATCTGCACCACGTTCT	0.373										HNSCC(7;0.00092)			33	162					0	0	0	0	T	139649017	T	T	139649017	3	4	76	1	0	0	0	0	1	0	0	0	3696	710	25	4	1429	4	COL22A1	8	139649017	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	19053058	139649017	6715005	79	15275											
SPATC1	375686	broad.mit.edu	37	chr8	145095233	145095233	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccaccaggggtctctcagaAcctgctggccaaccccatga	9	6	9	17	0	2	2	1	1	1	1	3	2	2	2	6	3	3	1	6	3	2	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr8:145095233A>T	uc011lkw.1	+	2	737	c.635A>T	c.(634-636)AAC>ATC	p.N212I	SPATC1_uc011lkx.1_Missense_Mutation_p.N212I	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	212										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GTCTCTCAGAACCTGCTGGCC	0.687													5	56					0	0	0	0	T	145095233	T	T	145095233	3	4	76	1	0	0	0	0	1	0	0	0	15083	43	2	5	641	5	SPATC1	8	145095233	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	5446216	145095233	1268789	80	15276											
TLN1	7094	broad.mit.edu	37	chr9	35707795	35707795	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgactgtacaaactggcgcTtggcagtaggattggtggta	9	11	14	7	1	0	1	0	1	0	0	0	2	0	2	0	5	2	5	0	5	4	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr9:35707795T>A	uc003zxt.2	-	35	4919	c.4565A>T	c.(4564-4566)AAG>ATG	p.K1522M		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1522	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AAACTGGCGCTTGGCAGTAGG	0.547													73	132					0	0	0	0	A	35707795	A	A	35707795	3	1	76	1	0	0	0	0	1	0	0	0	16013	1609	56	5	3152	5	TLN1	9	35707795	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08		35707795	105505636	81	15277											
TRIM14	9830	broad.mit.edu	37	chr9	100862405	100862405	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtagtaatctgagttcagtGaatttccccttcagccaggt	10	13	9	9	0	3	2	2	2	1	0	4	2	4	2	3	1	1	3	3	1	3	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr9:100862405G>A	uc004ayd.2	-	3	363	c.345C>T	c.(343-345)TTC>TTT	p.F115F	TRIM14_uc004ayf.1_Silent_p.F22F|TRIM14_uc004ayg.1_Silent_p.F115F|TRIM14_uc004ayh.1_Silent_p.F115F|TRIM14_uc004ayi.1_Silent_p.F115F|TRIM14_uc004ayj.1_Silent_p.F22F	NM_033220	NP_150089	Q14142	TRI14_HUMAN	tripartite motif protein TRIM14 isoform alpha	115						cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.0559)				TGAGTTCAGTGAATTTCCCCT	0.353													14	71					0	0	0	0	A	100862405	A	A	100862405	2	1	76	1	0	0	0	0	0	0	0	1	16556	1281	45	2		2	TRIM14	9	100862405	Silent	SNP	G	TCGA-CN-6019-01A-11D-1683-08	65154610	100862405	40351026	82	15278											
INVS	27130	broad.mit.edu	37	chr9	103046750	103046750	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggcccccagcaagcagcctCctgctggcaacgtggcccaa	8	4	12	17	1	0	0	0	0	0	0	1	0	1	0	5	3	5	4	5	3	3	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr9:103046750C>T	uc004bap.1	+	13	2145	c.1933C>T	c.(1933-1935)CCT>TCT	p.P645S	INVS_uc011lve.1_Missense_Mutation_p.P549S|INVS_uc004bao.1_Missense_Mutation_p.P645S|INVS_uc004baq.1_Missense_Mutation_p.P549S|INVS_uc004bar.1_Missense_Mutation_p.P549S|INVS_uc010mtb.1_Missense_Mutation_p.P319S	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	645					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)				CAAGCAGCCTCCTGCTGGCAA	0.652													9	40					0	0	0	0	T	103046750	T	T	103046750	3	4	76	1	0	0	0	0	1	0	0	0	7826	855	30	2	1979	2	INVS	9	103046750	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	2184345	103046750	38166681	83	15279											
SEC16A	9919	broad.mit.edu	37	chr9	139345823	139345823	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtcggcacgatcccaccctGggggggcctccgagtctggc	5	6	15	15	3	1	0	0	0	1	0	4	2	3	0	4	5	0	1	4	5	0	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr9:139345823G>C	uc004chx.2	-	23	6506	c.6197C>G	c.(6196-6198)CCA>CGA	p.P2066R	SEC16A_uc004chr.2_5'Flank|SEC16A_uc004chs.2_5'UTR|SEC16A_uc004cht.2_Missense_Mutation_p.P97R|SEC16A_uc004chu.2_Missense_Mutation_p.P251R|SEC16A_uc004chv.3_Missense_Mutation_p.P1456R|SEC16A_uc004chw.2_Missense_Mutation_p.P2066R|SEC16A_uc010nbn.2_Missense_Mutation_p.P2066R	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1888	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		ATCCCACCCTGGGGGGGCCTC	0.632													3	23					0	0	0	0	C	139345823	C	C	139345823	3	2	76	1	0	0	0	0	1	0	0	0	14051	1348	47	4	916	4	SEC16A	9	139345823	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	36299073	139345823	1867608	84	15280											
PGBD3	267004	broad.mit.edu	37	chr10	50724315	50724315	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttccccgaataaattgtttGcacccgtgacgaccaaaata	13	11	6	11	3	0	1	0	1	0	0	1	3	1	1	4	0	1	2	4	0	6	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr10:50724315G>A	uc001jht.2	-	2	1101	c.846C>T	c.(844-846)TGC>TGT	p.C282C	ERCC6_uc001jhs.3_Intron|PGBD3_uc009xoe.2_Silent_p.C750C|PGBD3_uc001jhu.2_Silent_p.C750C	NM_170753	NP_736609	Q8N328	PGBD3_HUMAN	hypothetical protein LOC267004	282										pancreas(1)|breast(1)|skin(1)	3						TAAATTGTTTGCACCCGTGAC	0.413													7	30					0	0	0	0	A	50724315	A	A	50724315	2	1	76	1	0	0	0	0	0	0	0	1	11837	1311	46	4		4	PGBD3	10	50724315	Silent	SNP	G	TCGA-CN-6019-01A-11D-1683-08		50724315	84810432	85	15281											
DNMBP	23268	broad.mit.edu	37	chr10	101731794	101731794	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccaccactgccagcacctCaataatatctcccacaaaga	15	7	3	16	0	2	1	1	0	1	1	4	1	3	1	5	0	2	1	5	0	4	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr10:101731794C>T	uc001kqj.2	-	2	180	c.88G>A	c.(88-90)GAG>AAG	p.E30K		NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	30	SH3 1.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		GCCAGCACCTCAATAATATCT	0.468													32	103					0	0	0	0	T	101731794	T	T	101731794	3	4	76	1	0	0	0	0	1	0	0	0	4696	835	29	2	4709	2	DNMBP	10	101731794	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	51007479	101731794	33802953	86	15282											
MUC5B	727897	broad.mit.edu	37	chr11	1263968	1263968	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacagtcaccagctccaaagCcactccctcctccagtccag	10	6	5	20	0	1	0	1	0	0	0	6	0	6	0	7	0	2	1	7	0	1	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr11:1263968C>T	uc009ycr.1	+	47	8063	c.7937C>T	c.(7936-7938)GCC>GTC	p.A2646V	MUC5B_uc001ltb.2_Missense_Mutation_p.A1956V	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1953	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGCTCCAAAGCCACTCCCTCC	0.632													25	94					0	0	0	0	T	1263968	T	T	1263968	3	4	76	1	0	0	0	0	1	0	0	0	10032	739	26	4	5989	4	MUC5B	11	1263968	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08		1263968	133742548	87	15283											
C11orf53	341032	broad.mit.edu	37	chr11	111156591	111156591	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagatctgcaccacactccgGggtaccctaccccgcctcct	8	7	7	19	2	1	1	0	0	1	1	3	1	3	1	7	2	3	2	7	2	3	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr11:111156591G>A	uc001plc.2	+	4	670	c.523G>A	c.(523-525)GGG>AGG	p.G175R		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	175											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		CCACACTCCGGGGTACCCTAC	0.622													24	103					0	0	0	0	A	111156591	A	A	111156591	3	1	76	1	0	0	0	0	1	0	0	0	1654	1232	43	4	533	4	C11orf53	11	111156591	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	109892623	111156591	23849925	88	15284											
FAM55A	120400	broad.mit.edu	37	chr11	114393075	114393075	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atagccggtcaatttcccgaGggatataatcatgatctatc	12	12	8	9	2	3	1	2	1	1	0	5	3	4	2	2	2	1	0	2	2	5	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr11:114393075G>C	uc001ppa.2	-	6	1250	c.833C>G	c.(832-834)CCT>CGT	p.P278R	FAM55A_uc010rxd.1_Missense_Mutation_p.P127R	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	420						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		AATTTCCCGAGGGATATAATC	0.433													23	92					0	0	0	0	C	114393075	C	C	114393075	3	2	76	1	0	0	0	0	1	0	0	0	5616	1000	35	4	388	4	FAM55A	11	114393075	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	3236484	114393075	20613441	89	15285											
ANO2	57101	broad.mit.edu	37	chr12	5908715	5908715	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttatagaacactccatagCgcgcccattcttgatatagc	12	11	6	12	2	1	2	0	1	1	1	2	2	2	2	2	0	3	0	2	0	6	7			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr12:5908715C>T	uc001qnm.2	-	10	1073	c.1001G>A	c.(1000-1002)CGC>CAC	p.R334H		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	339	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity	p.R335H(1)		ovary(4)|large_intestine(2)|central_nervous_system(1)	7						CACTCCATAGCGCGCCCATTC	0.418													4	32					0	0	0	0	T	5908715	T	T	5908715	3	4	76	1	0	0	0	0	1	0	0	0	697	768	27	1	2063	1	ANO2	12	5908715	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08		5908715	127943180	90	15286											
CD163L1	283316	broad.mit.edu	37	chr12	7527960	7527960	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagttatccagaagtgacTcattccctaagcaatgaaac	15	9	7	10	0	1	3	1	2	0	1	3	4	3	3	2	0	2	2	2	0	5	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr12:7527960T>A	uc001qsy.2	-	11	2944	c.2918A>T	c.(2917-2919)GAG>GTG	p.E973V	CD163L1_uc010sge.1_Missense_Mutation_p.E983V	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	973	SRCR 9.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CAGAAGTGACTCATTCCCTAA	0.458													10	45					0	0	0	0	A	7527960	A	A	7527960	3	1	76	1	0	0	0	0	1	0	0	0	2983	1551	54	5	1479	5	CD163L1	12	7527960	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	1619245	7527960	126323935	91	15287											
RACGAP1	29127	broad.mit.edu	37	chr12	50386143	50386143	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcaacatccattttagtaTgtggactctgagccactcta	10	13	8	10	0	2	1	0	1	2	0	3	2	3	2	2	2	2	2	2	2	4	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr12:50386143T>G	uc001rvt.2	-	16	1773	c.1463A>C	c.(1462-1464)CAT>CCT	p.H488P	RACGAP1_uc009zlm.1_Missense_Mutation_p.H488P|RACGAP1_uc001rvs.2_Missense_Mutation_p.H488P|RACGAP1_uc001rvu.2_Missense_Mutation_p.H488P	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	488	Rho-GAP.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						CATTTTAGTATGTGGACTCTG	0.393													8	46					0	0	0	0	G	50386143	G	G	50386143	3	3	76	1	0	0	0	0	1	0	0	0	13042	1464	51	5	451	5	RACGAP1	12	50386143	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	42858183	50386143	83465752	92	15288											
APAF1	317	broad.mit.edu	37	chr12	99065373	99065373	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaatggacaccttcttggaCgacagccatttcctaatatt	12	13	6	10	1	1	0	0	0	1	0	2	3	2	2	3	2	1	0	3	2	4	7			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr12:99065373C>T	uc001tfz.2	+	12	2246	c.1669C>T	c.(1669-1671)CGA>TGA	p.R557*	APAF1_uc001tfy.2_Nonsense_Mutation_p.R546*|APAF1_uc001tga.2_Nonsense_Mutation_p.R546*|APAF1_uc001tgb.2_Nonsense_Mutation_p.R557*|APAF1_uc001tgc.2_Intron|APAF1_uc009zto.2_Translation_Start_Site	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	557					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	CCTTCTTGGACGACAGCCATT	0.413													10	110					0	0	0	0	T	99065373	T	T	99065373	4	4	76	1	0	0	0	0	0	1	0	0	755	528	19	1	1711	1	APAF1	12	99065373	Nonsense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	48679230	99065373	34786522	93	15289											
ALDH1L2	160428	broad.mit.edu	37	chr12	105434423	105434423	+	Frame_Shift_Del	DEL	C	-	-																															tgatgaccccctttggaaagCctgctttcacagacagttct																										TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr12:105434423delC	uc001tlc.2	-	16	2040	c.1913delG	c.(1912-1914)GGCfs	p.G638fs	ALDH1L2_uc009zuo.2_Frame_Shift_Del_p.G93fs|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	638	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						CTTTGGAAAGCCTGCTTTCAC	0.483													---	---	---								-	105434423	-	-	105434423	7	5	76	1	0	1	0	1	0	0	0	0	495	739	26	0	890	0	ALDH1L2	12	105434423	Frame_Shift_Del	DEL	C	TCGA-CN-6019-01A-11D-1683-08	6369050	105434423	28417472	94	15290											
MED13L	23389	broad.mit.edu	37	chr12	116445306	116445306	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgtcaccatcttcaaaggtAtatgggtcattcacttctcc	10	14	6	11	0	6	0	4	0	2	0	7	0	6	0	2	2	0	1	2	2	3	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr12:116445306A>G	uc001tvw.2	-	11	2203	c.2148T>C	c.(2146-2148)TAT>TAC	p.Y716Y		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	716					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CTTCAAAGGTATATGGGTCAT	0.433													23	135					0	0	0	0	G	116445306	G	G	116445306	2	3	76	1	0	0	0	0	0	0	0	1	9484	456	16	5		5	MED13L	12	116445306	Silent	SNP	A	TCGA-CN-6019-01A-11D-1683-08	11010883	116445306	17406589	95	15291											
RPLP0	6175	broad.mit.edu	37	chr12	120634606	120634606	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaccaaatcccatatcctcGtccgactcctccgactcttc	9	10	4	18	3	1	1	0	0	1	1	8	3	6	1	6	0	0	0	6	0	2	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr12:120634606G>A	uc001txp.2	-	8	1161	c.924C>T	c.(922-924)GAC>GAT	p.D308D	GCN1L1_uc001txo.2_5'Flank|RPLP0_uc001txq.2_Silent_p.D308D|RPLP0_uc001txr.2_Silent_p.D246D	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	308					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCATATCCTCGTCCGACTCCT	0.313													10	50					0	0	0	0	A	120634606	A	A	120634606	2	1	76	1	0	0	0	0	0	0	0	1	13669	1136	40	1		1	RPLP0	12	120634606	Silent	SNP	G	TCGA-CN-6019-01A-11D-1683-08	4189300	120634606	13217289	96	15292											
DNAH10	196385	broad.mit.edu	37	chr12	124341683	124341683	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcctcttttccttggtttGatttcggatctgtttcctgg	2	21	9	9	1	2	1	0	1	2	0	6	2	5	2	3	3	0	3	3	3	0	7			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr12:124341683G>T	uc001uft.3	+	36	6190	c.6165G>T	c.(6163-6165)TTG>TTT	p.L2055F		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2055					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCCTTGGTTTGATTTCGGATC	0.532													6	54					0.00307968	0.00329707	1	0	T	124341683	T	T	124341683	3	4	76	1	0	0	0	0	1	0	0	0	4620	1281	45	2	6307	2	DNAH10	12	124341683	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	3707077	124341683	9510212	97	15293											
LATS2	26524	broad.mit.edu	37	chr13	21562740	21562740	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcaggccggaaggccacGtgcgcgcgcggcggcgcctc	5	3	17	16	8	1	0	1	0	0	0	2	1	1	1	3	5	1	0	3	5	1	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr13:21562740G>A	uc009zzs.2	-	4	1544	c.1179C>T	c.(1177-1179)CAC>CAT	p.H393H	LATS2_uc001unr.3_Silent_p.H393H	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	393					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		GGAAGGCCACGTGCGCGCGCG	0.736													3	7					0	0	0	0	A	21562740	A	A	21562740	2	1	76	1	0	0	0	0	0	0	0	1	8687	1136	40	1		1	LATS2	13	21562740	Silent	SNP	G	TCGA-CN-6019-01A-11D-1683-08		21562740	93607138	98	15294											
NEK5	341676	broad.mit.edu	37	chr13	52682493	52682493	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tattctgacagatctctgggGacaggtagtaaggtgttcca	10	12	12	7	0	2	2	0	1	2	1	4	3	3	3	1	4	0	3	1	4	3	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr13:52682493G>T	uc001vge.2	-	8	655	c.515C>A	c.(514-516)TCC>TAC	p.S172Y	NEK5_uc001vgf.2_Missense_Mutation_p.S172Y	NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	172	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		GATCTCTGGGGACAGGTAGTA	0.338													24	53					1.5548e-18	2.05053e-18	1	0	T	52682493	T	T	52682493	3	4	76	1	0	0	0	0	1	0	0	0	10381	1174	41	2	1671	2	NEK5	13	52682493	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	31119753	52682493	62487385	99	15295											
FOXG1	2290	broad.mit.edu	37	chr14	29237527	29237527	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagctccgtgttgactcagAactcgctgggcaacaaccac	11	7	9	14	2	1	2	1	1	0	1	3	2	2	2	2	1	4	4	2	1	3	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr14:29237527A>C	uc001wqe.2	+	1	1241	c.1042A>C	c.(1042-1044)AAC>CAC	p.N348H		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	348					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GTTGACTCAGAACTCGCTGGG	0.657													18	117					0	0	0	0	C	29237527	C	C	29237527	3	2	76	1	0	0	0	0	1	0	0	0	6041	246	9	5	1044	5	FOXG1	14	29237527	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08		29237527	78112013	100	15296											
ARHGAP5	394	broad.mit.edu	37	chr14	32586346	32586346	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaaatatgttttcttatagCagaaaaagaaaactaagaac	20	12	5	4	0	1	3	0	0	1	3	1	3	1	3	0	0	3	2	0	0	11	7			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr14:32586346C>T	uc001wrl.2	+	3	3957	c.3718C>T	c.(3718-3720)CAG>TAG	p.Q1240*	ARHGAP5_uc001wrm.2_Intron|ARHGAP5_uc001wrn.2_Nonsense_Mutation_p.Q1240*|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	1240	Lys-rich.				cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TTTCTTATAGCAGAAAAAGAA	0.323													9	38					0	0	0	0	T	32586346	T	T	32586346	4	4	76	1	0	0	0	0	0	1	0	0	886	724	25	4	3724	4	ARHGAP5	14	32586346	Nonsense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	3348819	32586346	74763194	101	15297											
FERMT2	10979	broad.mit.edu	37	chr14	53345312	53345312	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaactacctgcagggctgcAaacatcatcatttcttcttc	10	13	5	13	0	5	0	3	0	2	0	6	0	5	0	1	1	5	3	1	1	3	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr14:53345312A>G	uc001xad.2	-	7	1006	c.951T>C	c.(949-951)TTT>TTC	p.F317F	FERMT2_uc001xac.2_Silent_p.F317F|FERMT2_uc001xae.2_Silent_p.F317F|FERMT2_uc001xaf.2_Silent_p.F317F	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	317	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					GCAGGGCTGCAAACATCATCA	0.413													26	80					0	0	0	0	G	53345312	G	G	53345312	2	3	76	1	0	0	0	0	0	0	0	1	5850	127	5	5		5	FERMT2	14	53345312	Silent	SNP	A	TCGA-CN-6019-01A-11D-1683-08	20758966	53345312	54004228	102	15298											
RPAP1	26015	broad.mit.edu	37	chr15	41819777	41819777	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aacgtcaaagctccatggtaCcaagagaaggtgctgtcgag	13	7	12	9	2	1	1	1	0	0	1	3	3	2	1	2	2	4	3	2	2	5	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr15:41819777C>T	uc001zod.2	-	12	1579	c.1455G>A	c.(1453-1455)TGG>TGA	p.W485*		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	485						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CTCCATGGTACCAAGAGAAGG	0.552													3	19					0	0	0	0	T	41819777	T	T	41819777	4	4	76	1	0	0	0	0	0	1	0	0	13606	508	18	4	2782	4	RPAP1	15	41819777	Nonsense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08		41819777	60711615	103	15299											
SPG11	80208	broad.mit.edu	37	chr15	44900683	44900683	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatatcagatggcaggacacTaggaggagtgcactgtggga	13	7	15	6	0	1	1	1	0	0	1	1	5	1	5	0	5	1	2	0	5	3	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr15:44900683T>C	uc001ztx.2	-	19	3443	c.3412A>G	c.(3412-3414)AGT>GGT	p.S1138G	SPG11_uc010ueh.1_Missense_Mutation_p.S1138G|SPG11_uc010uei.1_Missense_Mutation_p.S1138G	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1138	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		GGCAGGACACTAGGAGGAGTG	0.368													12	54					0	0	0	0	C	44900683	C	C	44900683	3	2	76	1	0	0	0	0	1	0	0	0	15107	1522	53	5	4007	5	SPG11	15	44900683	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	3080906	44900683	57630709	104	15300											
GLDN	342035	broad.mit.edu	37	chr15	51696913	51696913	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagatggccatttaatgcttTatcctgtgcagtttttgtca	9	17	8	7	0	1	1	1	0	0	1	2	1	2	1	2	1	2	3	2	1	3	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr15:51696913T>C	uc002aba.2	+	10	1787	c.1618T>C	c.(1618-1620)TAT>CAT	p.Y540H	GLDN_uc002abb.2_Missense_Mutation_p.Y416H	NM_181789	NP_861454	Q6ZMI3	GLDN_HUMAN	gliomedin	540	Extracellular (Potential).|Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		TTTAATGCTTTATCCTGTGCA	0.413													19	99					0	0	0	0	C	51696913	C	C	51696913	3	2	76	1	0	0	0	0	1	0	0	0	6471	1754	61	5	1656	5	GLDN	15	51696913	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	6796230	51696913	50834479	105	15301											
WDR72	256764	broad.mit.edu	37	chr15	53889325	53889325	+	Frame_Shift_Del	DEL	C	-	-																															tgtaactctagttcttctgtCcattccagctttggcagcat																										TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr15:53889325delC	uc002acj.2	-	18	3141	c.3099delG	c.(3097-3099)TGGfs	p.W1033fs		NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	1033										lung(1)|skin(1)	2				all cancers(107;0.0511)		GTTCTTCTGTCCATTCCAGCT	0.393													---	---	---								-	53889325	-	-	53889325	7	5	76	1	0	1	0	1	0	0	0	0	17390	856	30	0	221	0	WDR72	15	53889325	Frame_Shift_Del	DEL	C	TCGA-CN-6019-01A-11D-1683-08	2192412	53889325	48642067	106	15302											
RASGRF1	5923	broad.mit.edu	37	chr15	79350798	79350798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtatttctgcattaatgcctCatgctctgtggcgagggtcc	6	14	11	10	1	3	0	1	0	2	0	4	1	4	0	2	2	3	3	2	2	2	3	rs150686548		TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr15:79350798C>T	uc002beq.2	-	3	784	c.409G>A	c.(409-411)GAG>AAG	p.E137K	RASGRF1_uc002bep.2_Missense_Mutation_p.E137K|RASGRF1_uc010blm.1_Missense_Mutation_p.E59K|RASGRF1_uc002ber.3_Missense_Mutation_p.E137K	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	137					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						ATTAATGCCTCATGCTCTGTG	0.572													5	45					0	0	0	0	T	79350798	T	T	79350798	3	4	76	1	0	0	0	0	1	0	0	0	13137	835	29	2	3516	2	RASGRF1	15	79350798	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	25461473	79350798	23180594	107	15303											
CLDN6	9074	broad.mit.edu	37	chr16	3065430	3065430	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcagatgttgagtagcggGccatgtaatggctggggccc	7	8	18	8	1	0	2	0	1	0	1	0	2	0	2	2	5	1	5	2	5	2	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr16:3065430G>A	uc002csu.3	-	2	653	c.593C>T	c.(592-594)GCC>GTC	p.A198V		NM_021195	NP_067018	P56747	CLD6_HUMAN	claudin 6	198	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TGAGTAGCGGGCCATGTAATG	0.652													13	60					0	0	0	0	A	3065430	A	A	3065430	3	1	76	1	0	0	0	0	1	0	0	0	3504	1203	42	4	73	4	CLDN6	16	3065430	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08		3065430	87289323	108	15304											
TEKT5	146279	broad.mit.edu	37	chr16	10788235	10788235	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccgtctccaagttctggtTctcagtcagaagcctgtcca	8	11	9	13	1	4	1	2	0	3	1	7	2	5	1	4	1	1	2	4	1	2	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr16:10788235T>C	uc002czz.1	-	1	568	c.496A>G	c.(496-498)AAC>GAC	p.N166D		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	166	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						AAGTTCTGGTTCTCAGTCAGA	0.607													49	249					0	0	0	0	C	10788235	C	C	10788235	3	2	76	1	0	0	0	0	1	0	0	0	15822	1783	62	5	989	5	TEKT5	16	10788235	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	7722805	10788235	79566518	109	15305											
ZNF646	9726	broad.mit.edu	37	chr16	31087784	31087784	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggctgacagcatccctcggCcctaccgttgtcagcagtgt	7	9	11	14	2	1	1	1	1	0	0	3	1	2	1	3	2	3	4	3	2	1	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr16:31087784C>G	uc002eap.2	+	2	428	c.139C>G	c.(139-141)CCC>GCC	p.P47A	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						CATCCCTCGGCCCTACCGTTG	0.632													13	81					0	0	0	0	G	31087784	G	G	31087784	3	3	76	1	0	0	0	0	1	0	0	0	18129	739	26	4	141	4	ZNF646	16	31087784	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	20299549	31087784	59266969	110	15306											
ZNF646	9726	broad.mit.edu	37	chr16	31087829	31087829	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggctaccgtcaccccgggAgcctggttaaccatcgtcgg	6	7	14	14	4	1	0	1	0	0	0	3	1	1	1	5	5	3	2	5	5	2	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr16:31087829A>G	uc002eap.2	+	2	473	c.184A>G	c.(184-186)AGC>GGC	p.S62G	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	62	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						TCACCCCGGGAGCCTGGTTAA	0.602													13	61					0	0	0	0	G	31087829	G	G	31087829	3	3	76	1	0	0	0	0	1	0	0	0	18129	304	11	5	186	5	ZNF646	16	31087829	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	45	31087829	59266924	111	15307											
DUS2L	54920	broad.mit.edu	37	chr16	68112759	68112759	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagcccttccttgcacaagcGaaagagggaggctcctgacc	10	6	12	13	1	0	2	0	1	0	1	2	5	2	3	4	2	3	2	4	2	2	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr16:68112759G>A	uc002evi.2	+	17	1501	c.1352G>A	c.(1351-1353)CGA>CAA	p.R451Q	DUS2L_uc002evj.2_Missense_Mutation_p.R451Q|DUS2L_uc010vkk.1_Missense_Mutation_p.R416Q|DUS2L_uc010cez.2_Missense_Mutation_p.R364Q	NM_017803	NP_060273	Q9NX74	DUS2L_HUMAN	dihydrouridine synthase 2-like, SMM1 homolog	451					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		TTGCACAAGCGAAAGAGGGAG	0.627													13	57					0	0	0	0	A	68112759	A	A	68112759	3	1	76	1	0	0	0	0	1	0	0	0	4828	1058	37	1	1410	1	DUS2L	16	68112759	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	37024930	68112759	22241994	112	15308											
NUP88	4927	broad.mit.edu	37	chr17	5290432	5290432	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgaagtagttttttcatccTttagaaaaggcaagcaaaca	15	12	8	6	0	1	2	1	1	0	1	2	2	2	2	1	1	2	4	1	1	7	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:5290432T>C	uc002gbo.1	-	15	1943	c.1917_splice	c.e15-1	p.R639_splice	NUP88_uc002gbn.2_5'Flank|NUP88_uc010vsx.1_Splice_Site_p.R655_splice	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						TTTTTCATCCTTTAGAAAAGG	0.373													11	29					0	0	0	0	C	5290432	C	C	5290432	5	2	76	1	0	0	0	0	0	0	1	0	10825	1623	56	5	322	5	NUP88	17	5290432	Splice_Site	SNP	T	TCGA-CN-6019-01A-11D-1683-08		5290432	75904778	113	15309											
CHRNB1	1140	broad.mit.edu	37	chr17	7350422	7350422	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtgtcctccgacggctcCgtgcgttggcaacccccggg	3	8	15	15	5	0	0	0	0	0	0	3	1	3	0	5	4	2	3	5	4	1	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:7350422C>T	uc002ghb.2	+	5	455	c.414C>T	c.(412-414)TCC>TCT	p.S138S	CHRNB1_uc010vty.1_Silent_p.S66S|CHRNB1_uc010vtz.1_5'UTR	NM_000747	NP_000738	P11230	ACHB_HUMAN	nicotinic acetylcholine receptor beta 1 subunit	138	Extracellular (Potential).				behavioral response to nicotine|muscle contraction|muscle fiber development|neuromuscular synaptic transmission|postsynaptic membrane organization|regulation of membrane potential|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine binding|receptor activity			ovary(2)	2		Prostate(122;0.157)				CCGACGGCTCCGTGCGTTGGC	0.527													9	37					0	0	0	0	T	7350422	T	T	7350422	2	4	76	1	0	0	0	0	0	0	0	1	3405	639	23	1		1	CHRNB1	17	7350422	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08	2059990	7350422	73844788	114	15310											
TP53	7157	broad.mit.edu	37	chr17	7574034	7574034	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcgctcacgcccacggatCtgcagcaacagaggaggggg	11	3	15	12	3	2	1	1	0	1	1	2	3	2	3	1	4	4	3	1	4	2	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:7574034C>A	uc002gim.2	-	10	1188	c.994_splice	c.e10-1	p.I332_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_Splice_Site|TP53_uc010cng.1_Splice_Site|TP53_uc002gii.1_Splice_Site_p.I200_splice|TP53_uc010cnh.1_Splice_Site|TP53_uc010cni.1_Splice_Site|TP53_uc002gij.2_Splice_Site_p.I332_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(4)|p.I332fs*49(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCACGGATCTGCAGCAACA	0.403		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	15					0.000602214	0.000660259	1	0	A	7574034	A	A	7574034	5	1	76	1	0	0	0	0	0	0	1	0	16448	927	32	2	196	2	TP53	17	7574034	Splice_Site	SNP	C	TCGA-CN-6019-01A-11D-1683-08	223612	7574034	73621176	115	15311											
MYH2	4620	broad.mit.edu	37	chr17	10432731	10432731	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccaacttcaagtcacccTcaagtttcctcttagccctt	8	12	6	15	0	4	0	3	0	1	0	5	0	5	0	4	1	2	1	4	1	4	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:10432731T>A	uc010coi.2	-	25	3313	c.3185A>T	c.(3184-3186)GAG>GTG	p.E1062V	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E1062V|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1062	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CAAGTCACCCTCAAGTTTCCT	0.373													8	62					0	0	0	0	A	10432731	A	A	10432731	3	1	76	1	0	0	0	0	1	0	0	0	10088	1551	54	5	2704	5	MYH2	17	10432731	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	2858697	10432731	70762479	116	15312											
NF1	4763	broad.mit.edu	37	chr17	29548868	29548868	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcttttttaaaaaattcagGctctgctggttcttcatcag	9	17	6	9	0	6	0	3	0	3	0	6	0	6	0	0	2	1	3	0	2	3	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:29548868G>T	uc002hgg.2	+	15	1975	c.1642G>T	c.(1642-1644)GCT>TCT	p.A548S	NF1_uc002hgf.1_Missense_Mutation_p.A548S|NF1_uc002hgh.2_Missense_Mutation_p.A548S|NF1_uc010csn.1_Missense_Mutation_p.A408S	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	548					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AAAAATTCAGGCTCTGCTGGT	0.313			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			4	40					0.00909568	0.00945951	1	0	T	29548868	T	T	29548868	3	4	76	1	0	0	0	0	1	0	0	0	10410	1217	42	4	1700	4	NF1	17	29548868	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	19116137	29548868	51646342	117	15313											
WNK4	65266	broad.mit.edu	37	chr17	40940808	40940808	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagcccggaagagattgcagCtgccatggtgagggggagag	10	5	18	8	1	0	3	0	1	0	2	0	6	0	4	2	4	4	2	2	4	1	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:40940808C>A	uc002ibj.2	+	11	2171	c.2150C>A	c.(2149-2151)GCT>GAT	p.A717D	WNK4_uc010wgx.1_Missense_Mutation_p.A381D|WNK4_uc002ibk.1_Missense_Mutation_p.A489D|WNK4_uc010wgy.1_Missense_Mutation_p.A61D	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	717					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GAGATTGCAGCTGCCATGGTG	0.537													11	51					0.000151284	0.000171017	1	0	A	40940808	A	A	40940808	3	1	76	1	0	0	0	0	1	0	0	0	17448	797	28	4	2192	4	WNK4	17	40940808	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	11391940	40940808	40254402	118	15314											
MYCBPAP	84073	broad.mit.edu	37	chr17	48602250	48602250	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgcagagcaagctgactGcccatgaggcagtcaccgtc	9	9	11	12	1	1	3	1	2	0	1	2	3	1	3	2	1	4	4	2	1	1	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:48602250G>T	uc010wmr.1	+	13	1939	c.1777G>T	c.(1777-1779)GCC>TCC	p.A593S	MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	556					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CAAGCTGACTGCCCATGAGGC	0.582													19	80					5.03518e-11	6.27674e-11	1	0	T	48602250	T	T	48602250	3	4	76	1	0	0	0	0	1	0	0	0	10072	1319	46	4	1827	4	MYCBPAP	17	48602250	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	7661442	48602250	32592960	119	15315											
ABCA6	23460	broad.mit.edu	37	chr17	67094145	67094145	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaaaaggaaccatccggcaaCccagtccagagtcctatgtg	14	6	9	12	1	0	1	0	0	0	1	3	2	3	2	5	2	2	1	5	2	5	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:67094145C>T	uc002jhw.1	-	23	3211	c.3036G>A	c.(3034-3036)GGG>GGA	p.G1012G		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1012	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					CATCCGGCAACCCAGTCCAGA	0.368													6	27					0	0	0	0	T	67094145	T	T	67094145	2	4	76	1	0	0	0	0	0	0	0	1	36	494	18	4		4	ABCA6	17	67094145	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08	18491895	67094145	14101065	120	15316											
ABCA6	23460	broad.mit.edu	37	chr17	67111520	67111520	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatttctttttactcaccttCtgttggaacagacaatccat	11	16	4	10	0	3	1	1	0	2	1	4	2	4	2	2	1	2	1	2	1	4	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:67111520C>A	uc002jhw.1	-	12	1778	c.1603G>T	c.(1603-1605)GAA>TAA	p.E535*	ABCA6_uc002jhx.1_5'UTR	NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	535	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					TACTCACCTTCTGTTGGAACA	0.358													16	85					1.02788e-11	1.29017e-11	1	0	A	67111520	A	A	67111520	4	1	76	1	0	0	0	0	0	1	0	0	36	922	32	2	3362	2	ABCA6	17	67111520	Nonsense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	17375	67111520	14083690	121	15317											
DNAH17	8632	broad.mit.edu	37	chr17	76540009	76540009	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgttgaggttggcaattCttccatccaagtctaacagg	9	13	10	9	0	2	1	0	1	2	0	4	1	4	1	2	3	1	4	2	3	3	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:76540009C>A	uc002jvv.1	-	13	1674	c.1568G>T	c.(1567-1569)AGA>ATA	p.R523I						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTTGGCAATTCTTCCATCCAA	0.498													29	175					6.38683e-12	8.07225e-12	1	0	A	76540009	A	A	76540009	3	1	76	1	0	0	0	0	1	0	0	0	4623	913	32	2	11186	2	DNAH17	17	76540009	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	9428489	76540009	4655201	122	15318											
RNF213	57674	broad.mit.edu	37	chr17	78318661	78318661	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatttaagacgattcaatCaaaaccaagacctagacacg	18	8	6	9	2	2	3	2	0	0	3	2	4	2	3	2	0	1	1	2	0	7	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr17:78318661C>A	uc002jyh.1	+	4	968	c.745C>A	c.(745-747)CAA>AAA	p.Q249K		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ACGATTCAATCAAAACCAAGA	0.493													16	53					6.94344e-10	8.59664e-10	1	0	A	78318661	A	A	78318661	3	1	76	1	0	0	0	0	1	0	0	0	13542	827	29	2	6955	2	RNF213	17	78318661	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	1778652	78318661	2876549	123	15319											
EPB41L3	23136	broad.mit.edu	37	chr18	5419778	5419778	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctccgtttgtcctcttcctCgtcccgctcctcctcagcct	1	14	5	21	3	2	0	1	0	1	0	9	0	8	0	8	0	1	2	8	0	0	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr18:5419778C>T	uc002kmt.1	-	12	1524	c.1438G>A	c.(1438-1440)GAG>AAG	p.E480K	EPB41L3_uc010wzh.1_Missense_Mutation_p.E498K|EPB41L3_uc002kmu.1_Missense_Mutation_p.E498K|EPB41L3_uc010dkq.1_Missense_Mutation_p.E389K|EPB41L3_uc002kms.1_5'UTR|EPB41L3_uc010wze.1_5'UTR|EPB41L3_uc010wzf.1_5'UTR|EPB41L3_uc010wzg.1_5'UTR|EPB41L3_uc010dkr.2_Missense_Mutation_p.E59K	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	480	Hydrophilic.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						tcctcttcctcgtcccgctcc	0.388													9	46					0	0	0	0	T	5419778	T	T	5419778	3	4	76	1	0	0	0	0	1	0	0	0	5178	893	31	1	1869	1	EPB41L3	18	5419778	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08		5419778	72657470	124	15320											
ATP9B	374868	broad.mit.edu	37	chr18	76873335	76873335	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attgaaaataggctatctctAcacctactgggctcctctgg	10	12	8	11	0	2	1	0	1	2	0	4	1	3	1	2	3	2	2	2	3	6	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr18:76873335A>G	uc002lmx.2	+	4	553	c.539A>G	c.(538-540)TAC>TGC	p.Y180C	ATP9B_uc002lmv.1_RNA|ATP9B_uc002lmw.1_Missense_Mutation_p.Y180C|ATP9B_uc002lmy.1_RNA|ATP9B_uc002lmz.1_5'UTR|ATP9B_uc002lmu.2_Missense_Mutation_p.Y180C	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	180	Helical; (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		GGCTATCTCTACACCTACTGG	0.289													6	39					0	0	0	0	G	76873335	G	G	76873335	3	3	76	1	0	0	0	0	1	0	0	0	1201	391	14	5	553	5	ATP9B	18	76873335	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	71453557	76873335	1203913	125	15321											
RPL36	25873	broad.mit.edu	37	chr19	5691434	5691434	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttactgaaggtctccaaggaCaaacgggccctcaaatttat	13	10	8	10	1	2	1	1	1	1	0	3	2	2	2	2	3	2	0	2	3	6	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:5691434C>A	uc002mcv.2	+	3	267	c.198C>A	c.(196-198)GAC>GAA	p.D66E	RPL36_uc002mcw.2_Missense_Mutation_p.D66E	NM_033643	NP_378669	Q9Y3U8	RL36_HUMAN	ribosomal protein L36	66					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|structural constituent of ribosome				0						TCTCCAAGGACAAACGGGCCC	0.627											OREG0025183	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	77					0.00185496	0.00200954	1	0	A	5691434	A	A	5691434	3	1	76	1	0	0	0	0	1	0	0	0	13651	477	17	4	204	4	RPL36	19	5691434	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08		5691434	53437549	126	15322											
TMEM205	374882	broad.mit.edu	37	chr19	11456289	11456289	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcctcctaggttcccgccttCctccatcttgcagtcctggg	3	12	9	17	1	1	0	0	0	1	0	6	0	6	0	7	2	1	2	7	2	1	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:11456289C>T	uc002mrb.2	-	2	195	c.7G>A	c.(7-9)GAA>AAA	p.E3K	TMEM205_uc002mra.2_Missense_Mutation_p.E3K|TMEM205_uc002mqz.2_Missense_Mutation_p.E3K|TMEM205_uc002mrc.2_Missense_Mutation_p.E3K|CCDC159_uc010xlr.1_5'Flank|CCDC159_uc010xls.1_5'Flank|CCDC159_uc010xlt.1_5'Flank|CCDC159_uc010xlu.1_5'Flank|CCDC159_uc010xlv.1_5'Flank	NM_001145416	NP_001138888	Q6UW68	TM205_HUMAN	transmembrane protein 205	3						integral to membrane					0						TTCCCGCCTTCCTCCATCTTG	0.587													3	31					0	0	0	0	T	11456289	T	T	11456289	3	4	76	1	0	0	0	0	1	0	0	0	16196	864	30	2	574	2	TMEM205	19	11456289	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	5764855	11456289	47672694	127	15323											
ZNF136	7695	broad.mit.edu	37	chr19	12297983	12297983	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgggaaaccctttcattctCtgagttcatttcaagtgcat	9	15	8	9	0	4	1	3	1	1	0	5	2	4	2	1	1	2	2	1	1	2	4			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:12297983C>T	uc002mti.2	+	4	890	c.790C>T	c.(790-792)CTG>TTG	p.L264L	ZNF136_uc010xmh.1_Silent_p.L198L	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	264	C2H2-type 5.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						CTTTCATTCTCTGAGTTCATT	0.388													24	47					0	0	0	0	T	12297983	T	T	12297983	2	4	76	1	0	0	0	0	0	0	0	1	17793	912	32	2		2	ZNF136	19	12297983	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08	841694	12297983	46831000	128	15324											
UPF1	5976	broad.mit.edu	37	chr19	18966828	18966828	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcgtgcgcctctgcgccAagagccgtgaggccatcgac	7	6	14	14	5	1	2	0	1	1	1	3	3	1	2	4	2	3	0	4	2	1	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:18966828A>G	uc002nkg.2	+	12	1947	c.1672A>G	c.(1672-1674)AAG>GAG	p.K558E	UPF1_uc002nkf.2_Missense_Mutation_p.K547E	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	558					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCTCTGCGCCAAGAGCCGTGA	0.612													5	18					0	0	0	0	G	18966828	G	G	18966828	3	3	76	1	0	0	0	0	1	0	0	0	17071	131	5	5	1685	5	UPF1	19	18966828	Missense_Mutation	SNP	A	TCGA-CN-6019-01A-11D-1683-08	6668845	18966828	40162155	129	15325											
NCAN	1463	broad.mit.edu	37	chr19	19338426	19338426	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatggtgaggccaccgccaCggctccaccctcccctgctg	6	6	10	19	2	0	1	0	1	0	0	2	1	2	1	7	3	1	2	7	3	0	0	rs111534277	byFrequency	TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:19338426C>T	uc002nlz.2	+	8	2096	c.1997C>T	c.(1996-1998)ACG>ATG	p.T666M	NCAN_uc010ecc.1_Missense_Mutation_p.T230M	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	666					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GCCACCGCCACGGCTCCACCC	0.612													20	108					0	0	0	0	T	19338426	T	T	19338426	3	4	76	1	0	0	0	0	1	0	0	0	10258	536	19	1	2023	1	NCAN	19	19338426	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	371598	19338426	39790557	130	15326											
ZNF91	7644	broad.mit.edu	37	chr19	23544891	23544891	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaagctttgccacattctTcacatttgtagggtttctct	9	17	6	9	0	3	0	1	0	2	0	4	0	3	0	1	1	2	3	1	1	3	7			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:23544891T>A	uc002nre.2	-	4	1003	c.890A>T	c.(889-891)GAA>GTA	p.E297V	ZNF91_uc010xrj.1_Missense_Mutation_p.E265V	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	297	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GCCACATTCTTCACATTTGTA	0.393													18	86					0	0	0	0	A	23544891	A	A	23544891	3	1	76	1	0	0	0	0	1	0	0	0	18267	1783	62	5	2689	5	ZNF91	19	23544891	Missense_Mutation	SNP	T	TCGA-CN-6019-01A-11D-1683-08	4206465	23544891	35584092	131	15327											
ATP4A	495	broad.mit.edu	37	chr19	36051747	36051747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaaggttcttaaagctggCgatgatgttggtgctcttga	9	13	12	7	1	2	2	0	2	2	0	2	3	2	2	0	3	2	4	0	3	3	4	rs148572774	byFrequency	TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:36051747C>T	uc002oal.1	-	5	537	c.508G>A	c.(508-510)GCC>ACC	p.A170T	ATP4A_uc010eee.1_5'Flank	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	170	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	TTAAAGCTGGCGATGATGTTG	0.562													13	95					0	0	0	0	T	36051747	T	T	36051747	3	4	76	1	0	0	0	0	1	0	0	0	1147	768	27	1	2671	1	ATP4A	19	36051747	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	12506856	36051747	23077236	132	15328											
IRGC	56269	broad.mit.edu	37	chr19	44222644	44222644	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggctcccttctcctctgcaGgcgctgaggatcacgcatcc	5	10	10	16	2	3	1	1	1	2	0	6	2	5	2	3	3	1	4	3	3	0	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:44222644G>A	uc002oxh.2	+	2	82	c.-65_splice	c.e2-1			NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema							membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CTCCTCTGCAGGCGCTGAGGA	0.627													20	64					0	0	0	0	A	44222644	A	A	44222644	5	1	76	1	0	0	0	0	0	0	1	0	7877	1014	35	4		4	IRGC	19	44222644	Splice_Site	SNP	G	TCGA-CN-6019-01A-11D-1683-08	8170897	44222644	14906339	133	15329											
BCL3	602	broad.mit.edu	37	chr19	45262845	45262845	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccctggccggccggtgccCccctccccagctccaggagg	3	4	14	20	2	0	0	0	0	0	0	2	1	2	1	9	6	2	1	9	6	0	0			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:45262845C>A	uc010xxe.1	+	9	1408	c.1338C>A	c.(1336-1338)CCC>CCA	p.P446P		NM_005178	NP_005169	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	446	Pro/Ser-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			ovary(1)|lung(1)	2	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				GGCCGGTGCCCCCCTCCCCAG	0.667			T	IGH@	CLL 								19	60					2.94398e-08	3.59601e-08	1	0	A	45262845	A	A	45262845	2	1	76	1	0	0	0	0	0	0	0	1	1377	610	22	4		4	BCL3	19	45262845	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08	1040201	45262845	13866138	134	15330											
ZNF415	55786	broad.mit.edu	37	chr19	53611805	53611805	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggatttgccacactcattaCatttgtaaggtttttctcca	10	16	6	9	0	2	0	1	0	1	0	3	1	2	1	2	2	2	2	2	2	2	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:53611805C>A	uc002qax.2	-	7	1986	c.1637G>T	c.(1636-1638)TGT>TTT	p.C546F	ZNF415_uc002qat.2_Missense_Mutation_p.C510F|ZNF415_uc002qaw.2_Missense_Mutation_p.C498F|ZNF415_uc010yds.1_Missense_Mutation_p.C498F|ZNF415_uc010ydt.1_Missense_Mutation_p.C498F|ZNF415_uc002qau.2_Missense_Mutation_p.C485F|ZNF415_uc002qav.2_Missense_Mutation_p.C510F|ZNF415_uc002qba.2_Missense_Mutation_p.C268F|ZNF415_uc002qay.2_Missense_Mutation_p.C485F|ZNF415_uc002qaz.2_Missense_Mutation_p.C546F	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	546	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		ACACTCATTACATTTGTAAGG	0.413													25	161					4.87955e-14	6.25408e-14	1	0	A	53611805	A	A	53611805	3	1	76	1	0	0	0	0	1	0	0	0	17959	478	17	4	178	4	ZNF415	19	53611805	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	8348960	53611805	5517178	135	15331											
LILRA1	11024	broad.mit.edu	37	chr19	55106221	55106221	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgtcaggggatcctggaGacccaggagtaccgtctgta	8	9	15	9	1	2	1	1	0	1	1	3	4	3	3	3	5	1	2	3	5	2	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:55106221G>A	uc002qgh.1	+	4	344	c.162G>A	c.(160-162)GAG>GAA	p.E54E	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Silent_p.E54E	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	54	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GGATCCTGGAGACCCAGGAGT	0.582													15	85					0	0	0	0	A	55106221	A	A	55106221	2	1	76	1	0	0	0	0	0	0	0	1	8825	933	33	2		2	LILRA1	19	55106221	Silent	SNP	G	TCGA-CN-6019-01A-11D-1683-08	1494416	55106221	4022762	136	15332											
ZNF132	7691	broad.mit.edu	37	chr19	58945525	58945526	+	Frame_Shift_Ins	INS	-	T	T																															ttcactgcattcatacggtcINStttctccagtgtgaactctc																										TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr19:58945525_58945526insT	uc002qst.3	-	3	1686_1687	c.1285_1286insA	c.(1285-1287)AGAfs	p.R429fs		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	429						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		TTCATACGGTCTTTCTCCAGTG	0.465													---	---	---								T	58945526	T	T	58945525	7	5	76	1	0	1	1	0	0	0	0	0	17789	913	32	0	838	0	ZNF132	19	58945525	Frame_Shift_Ins	INS	-	TCGA-CN-6019-01A-11D-1683-08	3839304	58945525	183458	137	15333											
MACROD2	140733	broad.mit.edu	37	chr20	15210612	15210612	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatactgtagggccaataGccaggggccatattaatggt	11	10	11	9	0	0	0	0	0	0	0	1	0	1	0	4	4	2	1	4	4	6	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr20:15210612G>T	uc002wou.2	+	6	709	c.445G>T	c.(445-447)GCC>TCC	p.A149S	MACROD2_uc002wot.2_Missense_Mutation_p.A149S|MACROD2_uc002woz.2_5'UTR	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1	149	Macro.										0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				AGGGCCAATAGCCAGGGGCCA	0.358													5	31					2.7689e-08	3.40499e-08	1	0	T	15210612	T	T	15210612	3	4	76	1	0	0	0	0	1	0	0	0	9197	971	34	4	467	4	MACROD2	20	15210612	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08		15210612	47814908	138	15334											
C20orf26	26074	broad.mit.edu	37	chr20	20150070	20150070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acacctgcaccctcgagcagGacctctacgtcttccaccgg	8	7	8	18	3	2	0	0	0	2	0	4	2	3	1	5	2	3	2	5	2	1	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr20:20150070G>A	uc002wru.2	+	13	1427	c.1351G>A	c.(1351-1353)GAC>AAC	p.D451N	C20orf26_uc010zse.1_Missense_Mutation_p.D431N|C20orf26_uc010zsf.1_Missense_Mutation_p.D451N	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	451										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCTCGAGCAGGACCTCTACGT	0.493													14	71					0	0	0	0	A	20150070	A	A	20150070	3	1	76	1	0	0	0	0	1	0	0	0	2116	1174	41	2	1397	2	C20orf26	20	20150070	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	4939458	20150070	42875450	139	15335											
DLGAP4	22839	broad.mit.edu	37	chr20	35060815	35060815	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggctgatgacactaggccGccaggcagaacgcagccagc	10	4	14	13	2	0	3	0	2	0	1	0	3	0	3	3	3	3	3	3	3	2	1	rs141000110	byFrequency	TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr20:35060815G>A	uc002xff.2	+	3	1130	c.695G>A	c.(694-696)CGC>CAC	p.R232H	DLGAP4_uc010zvp.1_Missense_Mutation_p.R232H	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	232					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				ACACTAGGCCGCCAGGCAGAA	0.597													9	85					0	0	0	0	A	35060815	A	A	35060815	3	1	76	1	0	0	0	0	1	0	0	0	4584	1087	38	1	697	1	DLGAP4	20	35060815	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	14910745	35060815	27964705	140	15336											
NCOA3	8202	broad.mit.edu	37	chr20	46254145	46254145	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaaactatttccaatgatGatgatgttcaaaaagccgat	17	11	7	6	1	1	3	1	3	0	0	2	5	2	3	2	0	2	1	2	0	6	3			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr20:46254145G>A	uc002xtk.2	+	5	482	c.277G>A	c.(277-279)GAT>AAT	p.D93N	NCOA3_uc010ght.1_Missense_Mutation_p.D93N|NCOA3_uc002xtl.2_Missense_Mutation_p.D93N|NCOA3_uc002xtm.2_Missense_Mutation_p.D93N|NCOA3_uc002xtn.2_Missense_Mutation_p.D93N|NCOA3_uc010zyc.1_5'Flank	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	93					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TTCCAATGATGATGATGTTCA	0.368													18	45					0	0	0	0	A	46254145	A	A	46254145	3	1	76	1	0	0	0	0	1	0	0	0	10284	1290	45	2	287	2	NCOA3	20	46254145	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	11193330	46254145	16771375	141	15337											
PHACTR3	116154	broad.mit.edu	37	chr20	58330263	58330263	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaagcaaaacttgcaaccccGatggaggaccccgatctgta	14	6	9	12	2	1	0	0	0	1	0	1	4	1	2	4	2	4	3	4	2	5	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr20:58330263G>A	uc002yau.2	+	4	852	c.385G>A	c.(385-387)GAT>AAT	p.D129N	PHACTR3_uc002yat.2_Missense_Mutation_p.D126N|PHACTR3_uc010zzw.1_Missense_Mutation_p.D88N|PHACTR3_uc002yav.2_Missense_Mutation_p.D88N|PHACTR3_uc002yaw.2_Missense_Mutation_p.D88N|PHACTR3_uc002yax.2_Missense_Mutation_p.D88N	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	129						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			TTGCAACCCCGATGGAGGACC	0.567													9	30					0	0	0	0	A	58330263	A	A	58330263	3	1	76	1	0	0	0	0	1	0	0	0	11866	1058	37	1	399	1	PHACTR3	20	58330263	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	12076118	58330263	4695257	142	15338											
TPTE	7179	broad.mit.edu	37	chr21	10920139	10920139	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggttttatctgttcgcCtttctccaaaataatacagg	9	16	8	8	1	2	0	0	0	2	0	4	0	2	0	2	2	1	2	2	2	5	6			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr21:10920139C>T	uc002yip.1	-	19	1483	c.1115G>A	c.(1114-1116)AGG>AAG	p.R372K	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.R354K|TPTE_uc002yir.1_Missense_Mutation_p.R334K|TPTE_uc010gkv.1_Missense_Mutation_p.R234K	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	372	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATCTGTTCGCCTTTCTCCAAA	0.378													15	131					0	0	0	0	T	10920139	T	T	10920139	3	4	76	1	0	0	0	0	1	0	0	0	16497	681	24	4	564	4	TPTE	21	10920139	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08		10920139	37209756	143	15339											
TPTE	7179	broad.mit.edu	37	chr21	10944746	10944746	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagaatcacaataatggcaGtatctaaaatgttaaataag	20	10	7	4	0	2	1	1	0	1	1	2	2	2	1	0	1	0	3	0	1	10	5			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr21:10944746G>T	uc002yip.1	-	11	856	c.488C>A	c.(487-489)ACT>AAT	p.T163N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.T145N|TPTE_uc002yir.1_Missense_Mutation_p.T125N|TPTE_uc010gkv.1_Missense_Mutation_p.T25N	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	163					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATAATGGCAGTATCTAAAAT	0.318													10	189					2.17888e-05	2.54202e-05	1	0	T	10944746	T	T	10944746	3	4	76	1	0	0	0	0	1	0	0	0	16497	1029	36	4	1223	4	TPTE	21	10944746	Missense_Mutation	SNP	G	TCGA-CN-6019-01A-11D-1683-08	24607	10944746	37185149	144	15340											
NCAM2	4685	broad.mit.edu	37	chr21	22906914	22906914	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacagaggatgaaagagttaCtaatcacgaagatgggagcc	17	6	12	6	1	1	4	1	1	0	3	1	7	1	6	1	2	3	1	1	2	5	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr21:22906914C>A	uc002yld.1	+	17	2588	c.2339C>A	c.(2338-2340)ACT>AAT	p.T780N	NCAM2_uc011acb.1_Missense_Mutation_p.T638N	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	780	Cytoplasmic (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GAAAGAGTTACTAATCACGAA	0.398													8	32					0.00448238	0.00477072	1	0	A	22906914	A	A	22906914	3	1	76	1	0	0	0	0	1	0	0	0	10257	565	20	4	2405	4	NCAM2	21	22906914	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	11962168	22906914	25222981	145	15341											
C2CD2	25966	broad.mit.edu	37	chr21	43332500	43332500	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttcgtcagggtgctggagaaCctctgaacaggatcgttcag	9	10	13	9	2	3	2	2	1	1	1	5	4	3	3	1	3	3	2	1	3	2	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr21:43332500C>A	uc002yzw.2	-	7	1136	c.894G>T	c.(892-894)AGG>AGT	p.R298S	C2CD2_uc002yzu.2_Missense_Mutation_p.R130S|C2CD2_uc002yzv.2_Missense_Mutation_p.R143S|C2CD2_uc002yzx.1_Missense_Mutation_p.R143S	NM_015500	NP_056315	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2 isoform	298	C2.					cytosol|extracellular region|nucleus				ovary(1)	1						TGCTGGAGAACCTCTGAACAG	0.488													4	18					0.00909568	0.00945951	1	0	A	43332500	A	A	43332500	3	1	76	1	0	0	0	0	1	0	0	0	2162	506	18	4	1228	4	C2CD2	21	43332500	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08	20425586	43332500	4797395	146	15342											
MYO18B	84700	broad.mit.edu	37	chr22	26194047	26194047	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccatctaccacctgggtgCggcgggggcctgcaaaggta	8	6	15	12	2	1	0	0	0	1	0	1	0	1	0	4	5	4	2	4	5	3	2			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr22:26194047C>T	uc003abz.1	+	12	2754	c.2504C>T	c.(2503-2505)GCG>GTG	p.A835V	MYO18B_uc003aca.1_Missense_Mutation_p.A716V|MYO18B_uc010guy.1_Missense_Mutation_p.A716V|MYO18B_uc010guz.1_Missense_Mutation_p.A716V|MYO18B_uc011aka.1_Intron|MYO18B_uc011akb.1_Missense_Mutation_p.A348V	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	835	Myosin head-like.		A -> G (in a lung squamous cell carcinoma sample; somatic mutation).			nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CACCTGGGTGCGGCGGGGGCC	0.662													9	17					0	0	0	0	T	26194047	T	T	26194047	3	4	76	1	0	0	0	0	1	0	0	0	10119	768	27	1	2546	1	MYO18B	22	26194047	Missense_Mutation	SNP	C	TCGA-CN-6019-01A-11D-1683-08		26194047	25110519	147	15343											
HMGXB4	10042	broad.mit.edu	37	chr22	35689036	35689037	+	Frame_Shift_Del	DEL	TG	-	-																															tgcttctggattccattatcTgtgcccttggccccttggca																										TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chr22:35689036_35689037delTG	uc003anl.2	+	10	1864_1865	c.1690_1691delTG	c.(1690-1692)TGTfs	p.C564fs	HMGXB4_uc003ank.2_Frame_Shift_Del_p.C455fs	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	564					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						TTCCATTATCTGTGCCCTTGGC	0.49													---	---	---								-	35689037	-	-	35689036	7	5	76	1	0	1	0	1	0	0	0	0	7278	1580	55	0	1724	0	HMGXB4	22	35689036	Frame_Shift_Del	DEL	TG	TCGA-CN-6019-01A-11D-1683-08	9494989	35689036	15615530	148	15344											
KIAA1210	57481	broad.mit.edu	37	chrX	118221839	118221839	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggaaagatgtctgggaagCagctgctccttagaaatgtc	11	10	13	7	0	1	2	0	0	1	2	3	4	2	4	1	2	3	3	1	2	4	1			TCGA-CN-6019-01A-11D-1683-08	TCGA-CN-6019-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	00769a89-ffc5-46f5-a42e-25b3eae886c2	424fb678-3744-4165-b4b3-daffa0319990	g.chrX:118221839C>A	uc004era.3	-	11	3354	c.3354G>T	c.(3352-3354)CTG>CTT	p.L1118L		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1118										ovary(4)|skin(1)	5						GTCTGGGAAGCAGCTGCTCCT	0.488													6	77					0.00116845	0.0012734	1	0	A	118221839	A	A	118221839	2	1	76	1	0	0	0	0	0	0	0	1	8253	697	25	4		4	KIAA1210	23	118221839	Silent	SNP	C	TCGA-CN-6019-01A-11D-1683-08		118221839	37048721	149	15345											
PLEKHG5	57449	broad.mit.edu	37	chr1	6529217	6529217	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcctcctcctcttcctcctCctgctcatcctcctcctctt	1	16	1	23	0	3	0	1	0	2	0	12	0	12	0	9	0	1	1	9	0	0	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:6529217C>T	uc001ano.1	-	20	2403	c.2302G>A	c.(2302-2304)GAG>AAG	p.E768K	PLEKHG5_uc001ann.1_Missense_Mutation_p.E749K|PLEKHG5_uc001anq.1_Missense_Mutation_p.E789K|PLEKHG5_uc001anp.1_Missense_Mutation_p.E789K|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Missense_Mutation_p.E273K|PLEKHG5_uc009vma.1_Missense_Mutation_p.E552K|PLEKHG5_uc010nzr.1_Missense_Mutation_p.E781K|PLEKHG5_uc001ank.1_Missense_Mutation_p.E712K|PLEKHG5_uc009vmb.1_Missense_Mutation_p.E712K|PLEKHG5_uc001anl.1_Missense_Mutation_p.E712K|PLEKHG5_uc001anm.1_Missense_Mutation_p.E712K|PLEKHG5_uc001anr.1_5'UTR	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	768	Glu-rich.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		tcttcctcctcctgctcatcc	0.433													17	87					0	0	0	0	T	6529217	T	T	6529217	3	4	77	1	0	0	0	0	1	0	0	0	12128	864	30	2	898	2	PLEKHG5	1	6529217	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08		6529217	242721404	1	15346											
RPS6KA1	6195	broad.mit.edu	37	chr1	26888033	26888033	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacgtgtacctggtgacagAgctgatgcggggtggggagc	8	7	18	8	2	0	3	0	2	0	1	0	4	0	4	1	5	4	2	1	5	1	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:26888033A>T	uc001bmr.1	+	17	1632	c.1469A>T	c.(1468-1470)GAG>GTG	p.E490V	RPS6KA1_uc010ofe.1_Missense_Mutation_p.E398V|RPS6KA1_uc010off.1_Missense_Mutation_p.E474V|RPS6KA1_uc001bms.1_Missense_Mutation_p.E499V|RPS6KA1_uc009vsl.1_Missense_Mutation_p.E333V	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	490	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		CTGGTGACAGAGCTGATGCGG	0.582													16	132					0	0	0	0	T	26888033	T	T	26888033	3	4	77	1	0	0	0	0	1	0	0	0	13715	304	11	5	1674	5	RPS6KA1	1	26888033	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	20358816	26888033	222362588	2	15347											
EYA3	2140	broad.mit.edu	37	chr1	28339624	28339624	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagagctgcggtgcttaccaGaggaaagtctctgtgctgca	9	9	13	10	1	1	2	0	0	1	2	2	3	1	3	1	2	6	4	1	2	2	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:28339624G>C	uc001bpi.1	-	9	932	c.767C>G	c.(766-768)TCT>TGT	p.S256C	EYA3_uc010ofs.1_Missense_Mutation_p.S203C|EYA3_uc010oft.1_Missense_Mutation_p.S210C|EYA3_uc001bpj.2_Missense_Mutation_p.S210C|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3	256					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		GTGCTTACCAGAGGAAAGTCT	0.468													4	110					0	0	0	0	C	28339624	C	C	28339624	3	2	77	1	0	0	0	0	1	0	0	0	5355	942	33	2	994	2	EYA3	1	28339624	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	1451591	28339624	220910997	3	15348											
MACF1	23499	broad.mit.edu	37	chr1	39797053	39797053	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aaacctctctttggaggaggGcatagccagaaacctcatta	13	9	9	10	0	2	1	1	0	1	1	3	3	2	3	3	3	3	1	3	3	4	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:39797053G>A	uc010oiu.1	+	1	244	c.113G>A	c.(112-114)GGC>GAC	p.G38D	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1603	Plectin 1.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTGGAGGAGGGCATAGCCAGA	0.537													4	76					0	0	0	0	A	39797053	A	A	39797053	3	1	77	1	0	0	0	0	1	0	0	0	9195	1203	42	4	4884	4	MACF1	1	39797053	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	11457429	39797053	209453568	4	15349											
TTC22	55001	broad.mit.edu	37	chr1	55266812	55266812	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatgagggcgtctagatcgtCggccacagcctccagctccg	7	7	13	14	4	1	2	0	1	1	1	5	3	3	2	4	2	2	1	4	2	1	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:55266812C>T	uc009vzt.1	-	1	130	c.25G>A	c.(25-27)GAC>AAC	p.D9N	TTC22_uc001cxz.3_Missense_Mutation_p.D9N	NM_001114108	NP_001107580	Q5TAA0	TTC22_HUMAN	tetratricopeptide repeat domain 22 isoform 1	9							binding				0						TCTAGATCGTCGGCCACAGCC	0.667													3	26					0	0	0	0	T	55266812	T	T	55266812	3	4	77	1	0	0	0	0	1	0	0	0	16757	884	31	1	1815	1	TTC22	1	55266812	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	15469759	55266812	193983809	5	15350											
LEPR	3953	broad.mit.edu	37	chr1	66036308	66036308	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaattcgaatggacattatGagacagctgttgaacctaag	15	10	9	7	1	0	2	0	2	0	1	1	5	0	3	1	1	2	2	1	1	5	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:66036308G>T	uc001dci.2	+	4	395	c.193G>T	c.(193-195)GAG>TAG	p.E65*	LEPR_uc001dcg.2_Nonsense_Mutation_p.E65*|LEPR_uc001dch.2_Nonsense_Mutation_p.E65*|LEPR_uc009waq.2_Nonsense_Mutation_p.E65*|LEPR_uc001dcj.2_Nonsense_Mutation_p.E65*|LEPR_uc001dck.2_Nonsense_Mutation_p.E65*	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	65	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TGGACATTATGAGACAGCTGT	0.378													4	103					0.00909568	0.00922379	1	0	T	66036308	T	T	66036308	4	4	77	1	0	0	0	0	0	1	0	0	8768	1291	45	2	199	2	LEPR	1	66036308	Nonsense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	10769496	66036308	183214313	6	15351											
SFRS11	9295	broad.mit.edu	37	chr1	70716156	70716156	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gataaggaaaaggaccgggaAagaaaatcagagagtgataa	21	4	13	3	1	1	3	1	1	0	2	1	8	1	6	1	3	0	0	1	3	7	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:70716156A>G	uc001des.2	+	12	1351	c.1227A>G	c.(1225-1227)GAA>GAG	p.E409E	SFRS11_uc001det.2_Silent_p.E409E|SFRS11_uc001deu.2_Silent_p.E416E|SFRS11_uc001dev.2_Silent_p.E219E|SFRS11_uc001dew.2_Silent_p.E349E	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11	409					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						aggaCCGGGAAAGAAAATCAG	0.154													5	60					0	0	0	0	G	70716156	G	G	70716156	2	3	77	1	0	0	0	0	0	0	0	1	14231	11	1	5		5	SFRS11	1	70716156	Silent	SNP	A	TCGA-CN-6020-01A-11D-1683-08	4679848	70716156	178534465	7	15352											
SLC44A5	204962	broad.mit.edu	37	chr1	75683637	75683637	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccaaatgctagggatcctGtgtgatatctgcacaaaaat	14	11	8	8	0	1	1	0	1	1	0	3	2	3	2	2	1	2	2	2	1	5	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:75683637G>T	uc001dgu.2	-	18	1682	c.1538C>A	c.(1537-1539)ACA>AAA	p.T513K	SLC44A5_uc001dgt.2_Missense_Mutation_p.T513K|SLC44A5_uc001dgs.2_Missense_Mutation_p.T471K|SLC44A5_uc001dgr.2_Missense_Mutation_p.T471K|SLC44A5_uc010oqz.1_Missense_Mutation_p.T552K|SLC44A5_uc010ora.1_Missense_Mutation_p.T507K|SLC44A5_uc010orb.1_Missense_Mutation_p.T383K	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	513	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TAGGGATCCTGTGTGATATCT	0.284													4	45					0.00909568	0.00922379	1	0	T	75683637	T	T	75683637	3	4	77	1	0	0	0	0	1	0	0	0	14703	1377	48	4	760	4	SLC44A5	1	75683637	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	4967481	75683637	173566984	8	15353											
LPAR3	23566	broad.mit.edu	37	chr1	85331150	85331150	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttgtatgcggagacaagacGttggttttcctcttgacgta	8	14	11	8	3	1	3	0	1	1	2	2	4	2	3	1	2	1	4	1	2	3	7			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:85331150G>A	uc001dkl.2	-	1	693	c.654C>T	c.(652-654)AAC>AAT	p.N218N	LPAR3_uc009wcj.1_Silent_p.N218N	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	218	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						GAGACAAGACGTTGGTTTTCC	0.512													5	37					0	0	0	0	A	85331150	A	A	85331150	2	1	77	1	0	0	0	0	0	0	0	1	8956	1136	40	1		1	LPAR3	1	85331150	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	9647513	85331150	163919471	9	15354											
GBP3	2635	broad.mit.edu	37	chr1	89476691	89476693	+	In_Frame_Del	DEL	CTT	-	-																															cgaataaattcccgccttcaCttcttcttctagaggactga																										TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:89476691_89476693delCTT	uc001dmt.2	-	8	1461_1463	c.1256_1258delAAG	c.(1255-1260)GAAGTG>GTG	p.E419del	GBP3_uc010oss.1_In_Frame_Del_p.E340del|GBP3_uc001dmu.2_In_Frame_Del_p.E285del|GBP3_uc001dmv.2_Intron	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	419						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		CCCGCCTTCACTTCTTCTTCTAG	0.419													---	---	---								-	89476693	-	-	89476691	7	5	77	1	0	1	0	1	0	0	0	0	6310	565	20	0	545	0	GBP3	1	89476691	In_Frame_Del	DEL	CTT	TCGA-CN-6020-01A-11D-1683-08	4145541	89476691	159773930	10	15355											
GBP4	115361	broad.mit.edu	37	chr1	89657032	89657032	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagttgtctgattgcataagGaaatgcctttccagattttc	11	15	8	7	0	1	2	0	1	1	1	3	3	2	3	2	1	2	2	2	1	3	6			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:89657032G>A	uc001dnb.2	-	6	944	c.828C>T	c.(826-828)TTC>TTT	p.F276F		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	276						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		ATTGCATAAGGAAATGCCTTT	0.413													9	87					0	0	0	0	A	89657032	A	A	89657032	2	1	77	1	0	0	0	0	0	0	0	1	6311	1165	41	2		2	GBP4	1	89657032	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	180341	89657032	159593589	11	15356											
LRRC39	127495	broad.mit.edu	37	chr1	100620742	100620742	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catttcgttgcagccataacGtatgtagattttgcattctg	9	16	8	8	2	1	1	0	0	1	1	2	1	1	1	1	0	4	5	1	0	3	8	rs149823600		TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:100620742G>A	uc001dsw.1	-	8	876	c.677C>T	c.(676-678)ACG>ATG	p.T226M	LRRC39_uc001dsx.1_Missense_Mutation_p.T226M|LRRC39_uc001dsy.1_Missense_Mutation_p.T226M|LRRC39_uc001dsz.1_Missense_Mutation_p.T226M	NM_144620	NP_653221	Q96DD0	LRC39_HUMAN	leucine rich repeat containing 39	226	LRR 7.									ovary(2)|skin(1)	3		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0826)|all cancers(265;0.135)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		CAGCCATAACGTATGTAGATT	0.279													7	29					0	0	0	0	A	100620742	A	A	100620742	3	1	77	1	0	0	0	0	1	0	0	0	9045	1145	40	1	342	1	LRRC39	1	100620742	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	10963710	100620742	148629879	12	15357											
KCNA3	3738	broad.mit.edu	37	chr1	111216896	111216896	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcggatctcctcggagaaaAtgtcgatgggcacgttgacc	10	8	13	10	4	1	2	0	1	1	1	4	5	1	3	2	3	1	2	2	3	2	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:111216896A>T	uc001dzv.1	-	1	760	c.536T>A	c.(535-537)ATT>AAT	p.I179N		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	179						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTCGGAGAAAATGTCGATGGG	0.647													23	98					0	0	0	0	T	111216896	T	T	111216896	3	4	77	1	0	0	0	0	1	0	0	0	8043	101	4	5	1195	5	KCNA3	1	111216896	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	10596154	111216896	138033725	13	15358											
FAM46C	54855	broad.mit.edu	37	chr1	118166445	118166445	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtggtgaacgagagcaccGtgtgtctcatggggcatgaa	9	8	17	7	2	1	3	1	2	1	1	2	4	1	3	1	4	2	2	1	4	2	0			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:118166445G>T	uc001ehe.2	+	2	1154	c.955G>T	c.(955-957)GTG>TTG	p.V319L		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	319											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		CGAGAGCACCGTGTGTCTCAT	0.537										Multiple Myeloma(3;1.13e-06)			12	43					1.61879e-10	1.85005e-10	1	0	T	118166445	T	T	118166445	3	4	77	1	0	0	0	0	1	0	0	0	5599	1145	40	3	957	3	FAM46C	1	118166445	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	6949549	118166445	131084176	14	15359											
YY1AP1	55249	broad.mit.edu	37	chr1	155640205	155640205	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggatacatgaaaaccttgcTtgtggccaggatccaagcca	12	9	10	10	0	0	1	0	1	0	0	1	3	1	3	4	3	4	1	4	3	4	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:155640205T>C	uc001fln.2	-	8	856	c.832A>G	c.(832-834)AGC>GGC	p.S278G	YY1AP1_uc001flg.2_5'UTR|YY1AP1_uc010pgg.1_Missense_Mutation_p.S117G|YY1AP1_uc010pgh.1_Missense_Mutation_p.S201G|YY1AP1_uc010pgi.1_Missense_Mutation_p.S350G|YY1AP1_uc001flh.2_Missense_Mutation_p.S350G|YY1AP1_uc009wqt.2_Missense_Mutation_p.S201G|YY1AP1_uc001flk.2_Missense_Mutation_p.S201G|YY1AP1_uc001fll.2_Missense_Mutation_p.S212G|YY1AP1_uc009wqv.2_Intron|YY1AP1_uc001flm.2_Missense_Mutation_p.S201G|YY1AP1_uc001fli.2_Missense_Mutation_p.S212G|YY1AP1_uc009wqu.2_Missense_Mutation_p.S45G|YY1AP1_uc001flj.2_Missense_Mutation_p.S212G|YY1AP1_uc009wqw.2_Missense_Mutation_p.S201G|YY1AP1_uc001flo.2_Missense_Mutation_p.S146G|YY1AP1_uc001flp.2_Missense_Mutation_p.S212G|YY1AP1_uc010pgj.1_Missense_Mutation_p.S278G|YY1AP1_uc009wqx.2_Missense_Mutation_p.S350G|YY1AP1_uc010pgk.1_Intron	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	278					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					AAAACCTTGCTTGTGGCCAGG	0.428													31	60					0	0	0	0	C	155640205	C	C	155640205	3	2	77	1	0	0	0	0	1	0	0	0	17576	1609	56	5	1634	5	YY1AP1	1	155640205	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	37473760	155640205	93610416	15	15360											
KIF14	9928	broad.mit.edu	37	chr1	200550376	200550376	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgctgctgatagcattggcTtcctgaatcatcattgagag	9	14	10	8	0	2	3	2	3	0	1	3	4	3	3	1	1	3	4	1	1	2	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:200550376T>C	uc010ppk.1	-	20	3727	c.3288A>G	c.(3286-3288)GAA>GAG	p.E1096E	KIF14_uc010ppj.1_Silent_p.E605E	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1096	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TAGCATTGGCTTCCTGAATCA	0.328													18	75					0	0	0	0	C	200550376	C	C	200550376	2	2	77	1	0	0	0	0	0	0	0	1	8315	1606	56	5		5	KIF14	1	200550376	Silent	SNP	T	TCGA-CN-6020-01A-11D-1683-08	44910171	200550376	48700245	16	15361											
AGT	183	broad.mit.edu	37	chr1	230839947	230839947	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctcacacatacctcccccaCcctgatgcggtcattgctca	8	9	6	18	1	3	1	3	1	0	0	4	1	4	1	4	1	3	2	4	1	1	2	rs61751067		TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:230839947C>G	uc001hty.3	-	4	1769	c.1261G>C	c.(1261-1263)GTG>CTG	p.V421L	AGT_uc009xfe.2_Intron|AGT_uc009xff.2_Missense_Mutation_p.V393L	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	421					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	ACCTCCCCCACCCTGATGCGG	0.582													13	39					0	0	0	0	G	230839947	G	G	230839947	3	3	77	1	0	0	0	0	1	0	0	0	399	507	18	4	204	4	AGT	1	230839947	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	30289571	230839947	18410674	17	15362											
RYR2	6262	broad.mit.edu	37	chr1	237777871	237777871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccagttggagggactactGaattcctctttgtacctctc	8	13	8	12	0	2	1	0	1	2	0	4	3	3	3	3	2	2	2	3	2	3	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:237777871G>A	uc001hyl.1	+	37	5563	c.5443G>A	c.(5443-5445)GAA>AAA	p.E1815K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1815	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGGGACTACTGAATTCCTCTT	0.483													26	202					0	0	0	0	A	237777871	A	A	237777871	3	1	77	1	0	0	0	0	1	0	0	0	13834	1291	45	2	5589	2	RYR2	1	237777871	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	6937924	237777871	11472750	18	15363											
RYR2	6262	broad.mit.edu	37	chr1	237947096	237947096	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactaaaggatttgacgtcGtctgatacttttaaagaata	16	13	7	5	2	1	3	0	2	1	1	2	4	1	4	0	1	2	0	0	1	8	6			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:237947096G>A	uc001hyl.1	+	90	12204	c.12084G>A	c.(12082-12084)TCG>TCA	p.S4028S	RYR2_uc010pya.1_Silent_p.S443S	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4028	EF-hand.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATTTGACGTCGTCTGATACTT	0.423													4	19					0	0	0	0	A	237947096	A	A	237947096	2	1	77	1	0	0	0	0	0	0	0	1	13834	1132	40	1		1	RYR2	1	237947096	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	169225	237947096	11303525	19	15364											
CHRM3	1131	broad.mit.edu	37	chr1	240072485	240072485	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtaccagcagagacagtcGgtcatttttcacaagcgcgc	11	8	10	12	3	2	1	2	0	0	1	3	2	2	1	1	1	3	2	1	1	2	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:240072485G>A	uc001hyp.2	+	5	2513	c.1734G>A	c.(1732-1734)TCG>TCA	p.S578S		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	578	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	AGAGACAGTCGGTCATTTTTC	0.488													9	49					0	0	0	0	A	240072485	A	A	240072485	2	1	77	1	0	0	0	0	0	0	0	1	3393	1103	39	1		1	CHRM3	1	240072485	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	2125389	240072485	9178136	20	15365											
OR14A16	284532	broad.mit.edu	37	chr1	247978352	247978352	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgactggccttctgtggaaGggatcttcttgactgtagag	7	14	13	7	0	3	3	0	2	3	1	3	5	3	5	1	3	0	1	1	3	2	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr1:247978352G>A	uc001idm.1	-	1	680	c.680C>T	c.(679-681)CCT>CTT	p.P227L		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCTGTGGAAGGGATCTTCTT	0.403													10	54					0	0	0	0	A	247978352	A	A	247978352	3	1	77	1	0	0	0	0	1	0	0	0	10999	1000	35	4	253	4	OR14A16	1	247978352	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	7905867	247978352	1272269	21	15366											
RPS27A	6233	broad.mit.edu	37	chr2	55462059	55462059	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaagaagaataagcacaaGagaaagaaggttaagctggc	19	4	11	7	0	0	4	0	0	0	4	0	5	0	4	1	2	2	3	1	2	8	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:55462059G>A	uc010yow.1	+	5	479	c.282G>A	c.(280-282)AAG>AAA	p.K94K	C2orf63_uc002ryh.2_5'Flank|C2orf63_uc002ryi.2_5'Flank|C2orf63_uc002ryj.2_5'Flank|RPS27A_uc002ryk.2_Silent_p.K94K|RPS27A_uc002ryl.2_RNA|RPS27A_uc002rym.2_RNA	NM_001135592	NP_001129064	P62979	RS27A_HUMAN	ubiquitin and ribosomal protein S27a precursor	94	Lys-rich (highly basic).				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	metal ion binding|structural constituent of ribosome			ovary(1)	1						ATAAGCACAAGAGAAAGAAGG	0.398													12	17					0	0	0	0	A	55462059	A	A	55462059	2	1	77	1	0	0	0	0	0	0	0	1	13704	933	33	2		2	RPS27A	2	55462059	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08		55462059	187737314	22	15367											
USP34	9736	broad.mit.edu	37	chr2	61570972	61570972	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgactaagatgttcatggtaAatggaagctaaattgggaag	15	11	12	3	0	1	2	1	1	0	1	1	4	1	4	0	3	1	3	0	3	7	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:61570972A>G	uc002sbe.2	-	16	2500	c.2478T>C	c.(2476-2478)ATT>ATC	p.I826I		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	826					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GTTCATGGTAAATGGAAGCTA	0.363													17	94					0	0	0	0	G	61570972	G	G	61570972	2	3	77	1	0	0	0	0	0	0	0	1	17133	10	1	5		5	USP34	2	61570972	Silent	SNP	A	TCGA-CN-6020-01A-11D-1683-08	6108913	61570972	181628401	23	15368											
CLEC4F	165530	broad.mit.edu	37	chr2	71036884	71036884	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactcacgctttgttctgggCggcgttgaatggtgtcccat	5	13	13	10	3	2	1	1	1	1	0	3	2	3	1	1	3	0	3	1	3	1	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:71036884C>T	uc002shf.2	-	6	1722	c.1645G>A	c.(1645-1647)GCC>ACC	p.A549T	CLEC4F_uc010yqv.1_Missense_Mutation_p.A549T	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	549	Extracellular (Potential).|C-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						TTGTTCTGGGCGGCGTTGAAT	0.557													11	56					0	0	0	0	T	71036884	T	T	71036884	3	4	77	1	0	0	0	0	1	0	0	0	3531	768	27	1	132	1	CLEC4F	2	71036884	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	9465912	71036884	172162489	24	15369											
GCC2	9648	broad.mit.edu	37	chr2	109116150	109116150	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagagagacttcttcctgttAtaaatacgatgttgcagctc	11	13	9	8	1	1	2	0	0	1	2	3	5	2	2	1	0	3	4	1	0	4	6			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:109116150A>G	uc002tec.2	+	22	5078	c.4924A>G	c.(4924-4926)ATA>GTA	p.I1642V	GCC2_uc002ted.2_Missense_Mutation_p.I1541V	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1642	Mediates interaction with RAB9A.|GRIP.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						TCTTCCTGTTATAAATACGAT	0.443													19	277					0	0	0	0	G	109116150	G	G	109116150	3	3	77	1	0	0	0	0	1	0	0	0	6321	449	16	5	5010	5	GCC2	2	109116150	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	38079266	109116150	134083223	25	15370											
SMPD4	55627	broad.mit.edu	37	chr2	130911487	130911487	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgtttggcctgtgtgaTgagctgagcgaggcgcagga	6	11	18	6	2	0	3	0	3	0	0	0	5	0	4	1	3	2	3	1	3	0	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:130911487T>A	uc002tqq.1	-	17	2318	c.1798A>T	c.(1798-1800)ATC>TTC	p.I600F	SMPD4_uc002tqo.1_Missense_Mutation_p.I132F|SMPD4_uc002tqp.1_Missense_Mutation_p.I339F|SMPD4_uc010yzy.1_Missense_Mutation_p.I349F|SMPD4_uc010yzz.1_Missense_Mutation_p.I264F|SMPD4_uc002tqr.1_Missense_Mutation_p.I571F|SMPD4_uc002tqs.1_Missense_Mutation_p.I468F|SMPD4_uc002tqt.1_Missense_Mutation_p.I449F|SMPD4_uc010zaa.1_Missense_Mutation_p.I458F|SMPD4_uc010zab.1_Missense_Mutation_p.I498F|SMPD4_uc010zac.1_Missense_Mutation_p.I341F|SMPD4_uc010zad.1_Missense_Mutation_p.I236F	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	561					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GCCTGTGTGATGAGCTGAGCG	0.642													3	35					0	0	0	0	A	130911487	A	A	130911487	3	1	77	1	0	0	0	0	1	0	0	0	14871	1464	51	5	818	5	SMPD4	2	130911487	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	21795337	130911487	112287886	26	15371											
NEB	4703	broad.mit.edu	37	chr2	152385794	152385794	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctggctcaatggtgcagttgGatttatttctttggtatact	7	18	10	6	0	2	0	1	0	1	0	2	1	2	1	0	4	2	4	0	4	4	7			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:152385794G>C	uc010fnx.2	-	118	16753	c.16562C>G	c.(16561-16563)TCC>TGC	p.S5521C	NEB_uc002txr.2_Missense_Mutation_p.S1944C|NEB_uc002txt.3_Missense_Mutation_p.S26C	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5521					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGTGCAGTTGGATTTATTTCT	0.393													5	40					0	0	0	0	C	152385794	C	C	152385794	3	2	77	1	0	0	0	0	1	0	0	0	10356	1174	41	2	4060	2	NEB	2	152385794	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	21474307	152385794	90813579	27	15372											
CYTIP	9595	broad.mit.edu	37	chr2	158272595	158272595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcctggcccaggcaggggtCcaaacaaagacaattcatcc	12	5	11	13	0	1	1	1	0	0	1	3	1	3	1	4	5	1	1	4	5	3	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:158272595C>T	uc002tzj.1	-	8	746	c.674G>A	c.(673-675)GGA>GAA	p.G225E	CYTIP_uc010zcl.1_Missense_Mutation_p.G119E	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	225					regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						AGGCAGGGGTCCAAACAAAGA	0.498													11	41					0	0	0	0	T	158272595	T	T	158272595	3	4	77	1	0	0	0	0	1	0	0	0	4224	855	30	2	409	2	CYTIP	2	158272595	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	5886801	158272595	84926778	28	15373											
PPIG	9360	broad.mit.edu	37	chr2	170492733	170492733	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtgaaagatggatcaagggGgataagtaagatttaactat	16	10	13	2	0	1	3	1	1	0	2	1	5	1	5	0	4	1	1	0	4	6	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:170492733G>T	uc002uez.2	+	13	1369	c.1149G>T	c.(1147-1149)GGG>GGT	p.G383G	PPIG_uc010fpx.2_Silent_p.G368G|PPIG_uc010fpy.2_Silent_p.G376G|PPIG_uc002ufb.2_Silent_p.G383G|PPIG_uc002ufd.2_Silent_p.G380G	NM_004792	NP_004783	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G	383					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|central_nervous_system(1)	3					L-Proline(DB00172)	GGATCAAGGGGGATAAGTAAG	0.353													12	74					4.36969e-10	4.94164e-10	1	0	T	170492733	T	T	170492733	2	4	77	1	0	0	0	0	0	0	0	1	12384	1219	43	4		4	PPIG	2	170492733	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	12220138	170492733	72706640	29	15374											
TTN	7273	broad.mit.edu	37	chr2	179434069	179434069	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttggcgtgtccagaactCtcacagtaacaaaggcagac	13	7	10	11	1	1	2	1	0	1	2	3	3	2	2	1	2	2	2	1	2	3	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:179434069C>G	uc010zfg.1	-	275	69310	c.69086G>C	c.(69085-69087)AGA>ACA	p.R23029T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16724T|TTN_uc010zfi.1_Missense_Mutation_p.R16657T|TTN_uc010zfj.1_Missense_Mutation_p.R16532T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23956							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCCAGAACTCTCACAGTAAC	0.423													12	161					0	0	0	0	G	179434069	G	G	179434069	3	3	77	1	0	0	0	0	1	0	0	0	16803	913	32	2	31337	2	TTN	2	179434069	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	8941336	179434069	63765304	30	15375											
TTN	7273	broad.mit.edu	37	chr2	179664379	179664379	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctgggaggtgttttatgtGgcagctgttgcccagcggca	5	12	15	9	1	0	0	0	0	0	0	1	1	1	1	2	4	3	5	2	4	1	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:179664379G>A	uc002und.2	-	6	974	c.749C>T	c.(748-750)CCA>CTA	p.P250L	TTN_uc010zfg.1_Missense_Mutation_p.P250L|TTN_uc010zfh.1_Missense_Mutation_p.P250L|TTN_uc010zfi.1_Missense_Mutation_p.P250L|TTN_uc010zfj.1_Missense_Mutation_p.P250L|TTN_uc002unb.2_Missense_Mutation_p.P250L			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	250							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTTTATGTGGCAGCTGTTG	0.498													19	47					0	0	0	0	A	179664379	A	A	179664379	3	1	77	1	0	0	0	0	1	0	0	0	16803	1348	47	4	110667	4	TTN	2	179664379	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	230310	179664379	63534994	31	15376											
HECW2	57520	broad.mit.edu	37	chr2	197105285	197105285	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgatctcttcggataattaAcctgtccataaagagacaat	14	12	7	8	1	1	2	0	1	1	1	4	4	2	3	2	1	1	0	2	1	5	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:197105285A>G	uc002utm.1	-	21	3835	c.3652T>C	c.(3652-3654)TTA>CTA	p.L1218L	HECW2_uc002utl.1_Silent_p.L862L	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1218					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CGGATAATTAACCTGTCCATA	0.308													10	50					0	0	0	0	G	197105285	G	G	197105285	2	3	77	1	0	0	0	0	0	0	0	1	7082	57	2	5		5	HECW2	2	197105285	Silent	SNP	A	TCGA-CN-6020-01A-11D-1683-08	17440906	197105285	46094088	32	15377											
FAM117B	150864	broad.mit.edu	37	chr2	203621983	203621983	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctccacccccccttgtacaGagaagtagcagcacgcgcag	10	5	10	16	2	0	1	0	0	0	1	1	2	1	1	4	0	3	6	4	0	3	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:203621983G>A	uc010zhx.1	+	6	1162	c.1152G>A	c.(1150-1152)CAG>CAA	p.Q384Q		NM_173511	NP_775782	Q6P1L5	F117B_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	384										ovary(1)	1						CCCTTGTACAGAGAAGTAGCA	0.498													4	50					0	0	0	0	A	203621983	A	A	203621983	2	1	77	1	0	0	0	0	0	0	0	1	5438	933	33	2		2	FAM117B	2	203621983	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	6516698	203621983	39577390	33	15378											
UGT1A4	54657	broad.mit.edu	37	chr2	234627538	234627538	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcctcagtgtccagccCtgggctgagagtggaaaggt	7	9	13	12	0	1	1	1	1	0	1	4	3	4	2	4	3	1	1	4	3	1	0			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:234627538C>G	uc002vux.2	+	1	101	c.72C>G	c.(70-72)CCC>CCG	p.P24P	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Silent_p.P24P	NM_007120	NP_009051	P22310	UD14_HUMAN	UDP glycosyltransferase 1 family, polypeptide A4	24					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)	Imipramine(DB00458)|Lamotrigine(DB00555)|Paricalcitol(DB00910)|Trifluoperazine(DB00831)	GTGTCCAGCCCTGGGCTGAGA	0.657													10	58					0	0	0	0	G	234627538	G	G	234627538	2	3	77	1	0	0	0	0	0	0	0	1	17015	668	24	4		4	UGT1A4	2	234627538	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	31005555	234627538	8571835	34	15379											
ANKMY1	51281	broad.mit.edu	37	chr2	241463753	241463753	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agactccaggtttgtgtccaTaaatgatgatgaaaggattg	13	12	11	5	0	0	4	0	3	0	1	2	5	2	5	2	2	0	1	2	2	3	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr2:241463753T>C	uc002vyz.1	-	7	1343	c.1114A>G	c.(1114-1116)ATG>GTG	p.M372V	ANKMY1_uc002vza.1_Missense_Mutation_p.M231V|ANKMY1_uc010fzd.1_Missense_Mutation_p.M461V|ANKMY1_uc002vzb.1_Missense_Mutation_p.M231V|ANKMY1_uc002vzc.1_Missense_Mutation_p.M231V|ANKMY1_uc002vzd.1_Missense_Mutation_p.M231V|ANKMY1_uc010fze.1_Missense_Mutation_p.M41V|ANKMY1_uc002vze.2_Missense_Mutation_p.M133V	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	372							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TTTGTGTCCATAAATGATGAT	0.463													16	75					0	0	0	0	C	241463753	C	C	241463753	3	2	77	1	0	0	0	0	1	0	0	0	634	1406	49	5	1755	5	ANKMY1	2	241463753	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	6836215	241463753	1735620	35	15380											
THUMPD3	25917	broad.mit.edu	37	chr3	9426231	9426231	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttatctggaatgcgacacgtAtggcgaaaggtggatacagt	12	10	13	6	3	1	0	0	0	1	0	1	4	1	2	0	4	2	1	0	4	5	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr3:9426231A>G	uc003bro.3	+	10	1531	c.1383A>G	c.(1381-1383)GTA>GTG	p.V461V	LOC440944_uc003brm.2_Intron|THUMPD3_uc003brn.3_Silent_p.V461V	NM_001114092	NP_001107564	Q9BV44	THUM3_HUMAN	THUMP domain containing 3	461							methyltransferase activity|protein binding|RNA binding			ovary(1)	1	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.101)		TGCGACACGTATGGCGAAAGG	0.418													34	108					0	0	0	0	G	9426231	G	G	9426231	2	3	77	1	0	0	0	0	0	0	0	1	15950	436	16	5		5	THUMPD3	3	9426231	Silent	SNP	A	TCGA-CN-6020-01A-11D-1683-08		9426231	188596199	36	15381											
BSN	8927	broad.mit.edu	37	chr3	49690316	49690316	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctccccgacggaggagctGaggcaggcggccgagatgga	8	3	18	12	4	0	2	0	1	0	1	1	7	1	5	4	6	1	2	4	6	0	0			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr3:49690316G>A	uc003cxe.3	+	5	3441	c.3327G>A	c.(3325-3327)CTG>CTA	p.L1109L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1109					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CGGAGGAGCTGAGGCAGGCGG	0.642													13	91					0	0	0	0	A	49690316	A	A	49690316	2	1	77	1	0	0	0	0	0	0	0	1	1535	1277	45	2		2	BSN	3	49690316	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	40264085	49690316	148332114	37	15382											
MITF	4286	broad.mit.edu	37	chr3	70014334	70014334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctttcctcagtgtcccccGgagcttccaaaacaagcagc	9	9	7	16	1	1	0	1	0	0	0	5	1	5	1	5	1	4	2	5	1	3	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr3:70014334G>A	uc003dnz.2	+	10	1614	c.1498G>A	c.(1498-1500)GGA>AGA	p.G500R	MITF_uc011bgb.1_Missense_Mutation_p.G448R|MITF_uc003doa.2_Missense_Mutation_p.G499R|MITF_uc003dob.2_Missense_Mutation_p.G484R|MITF_uc003dod.2_Missense_Mutation_p.G475R|MITF_uc003doe.2_Missense_Mutation_p.G393R|MITF_uc003dof.2_Missense_Mutation_p.G399R	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	506					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		AGTGTCCCCCGGAGCTTCCAA	0.537			A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						4	65					0	0	0	0	A	70014334	A	A	70014334	3	1	77	1	0	0	0	0	1	0	0	0	9649	1117	39	1	1775	1	MITF	3	70014334	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	20324018	70014334	128008096	38	15383											
EPHA6	285220	broad.mit.edu	37	chr3	96706382	96706382	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacttgcaaagaaacatttaAtctgttttatatggaatcag	15	14	7	5	0	2	1	1	0	1	1	2	3	2	2	0	1	2	2	0	1	6	6			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr3:96706382A>G	uc010how.1	+	3	702	c.659A>G	c.(658-660)AAT>AGT	p.N220S	EPHA6_uc003drp.1_Missense_Mutation_p.N220S	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	125	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GAAACATTTAATCTGTTTTAT	0.398													10	161					0	0	0	0	G	96706382	G	G	96706382	3	3	77	1	0	0	0	0	1	0	0	0	5195	101	4	5	669	5	EPHA6	3	96706382	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	26692048	96706382	101316048	39	15384											
KIAA2018	205717	broad.mit.edu	37	chr3	113377897	113377897	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttagatttcgatacagactCaggtattaatgattcagagc	13	13	8	7	1	2	4	2	1	0	3	3	5	2	4	0	1	2	1	0	1	4	6			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr3:113377897C>T	uc003eam.2	-	7	3043	c.2632G>A	c.(2632-2634)GAG>AAG	p.E878K	KIAA2018_uc003eal.2_Missense_Mutation_p.E822K	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	878	Ser-rich.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GATACAGACTCAGGTATTAAT	0.438													40	95					0	0	0	0	T	113377897	T	T	113377897	3	4	77	1	0	0	0	0	1	0	0	0	8307	835	29	2	4109	2	KIAA2018	3	113377897	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	16671515	113377897	84644533	40	15385											
TM4SF1	4071	broad.mit.edu	37	chr3	149089484	149089484	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggttcttacctgttggtgaGagcagcaaaagccacatatg	12	10	11	8	0	1	1	0	1	1	1	1	2	1	1	2	2	4	4	2	2	4	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr3:149089484G>A	uc003exb.1	-	4	818	c.584C>T	c.(583-585)TCT>TTT	p.S195F	TM4SF1_uc003exc.1_Missense_Mutation_p.S106F	NM_014220	NP_055035	P30408	T4S1_HUMAN	transmembrane 4 superfamily member 1	195	Cytoplasmic (Probable).					integral to plasma membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CTGTTGGTGAGAGCAGCAAAA	0.398													29	130					0	0	0	0	A	149089484	A	A	149089484	3	1	77	1	0	0	0	0	1	0	0	0	16032	942	33	2	32	2	TM4SF1	3	149089484	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	35711587	149089484	48932946	41	15386											
TNIK	23043	broad.mit.edu	37	chr3	170928972	170928972	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catagtatgtagcaatattcCggtgatgagaatatttcttc	12	15	8	6	1	1	2	0	2	1	1	3	3	2	2	1	1	1	3	1	1	7	8			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr3:170928972C>G	uc003fhh.2	-	4	584	c.239G>C	c.(238-240)CGG>CCG	p.R80P	TNIK_uc003fhi.2_Missense_Mutation_p.R80P|TNIK_uc003fhj.2_Missense_Mutation_p.R80P|TNIK_uc003fhk.2_Missense_Mutation_p.R80P|TNIK_uc003fhl.2_Missense_Mutation_p.R80P|TNIK_uc003fhm.2_Missense_Mutation_p.R80P|TNIK_uc003fhn.2_Missense_Mutation_p.R80P|TNIK_uc003fho.2_Missense_Mutation_p.R80P	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	80	Protein kinase.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			AGCAATATTCCGGTGATGAGA	0.343													15	76					0	0	0	0	G	170928972	G	G	170928972	3	3	77	1	0	0	0	0	1	0	0	0	16379	652	23	3	3963	3	TNIK	3	170928972	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	21839488	170928972	27093458	42	15387											
KLHL24	54800	broad.mit.edu	37	chr3	183381346	183381346	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctacgatcctgtaacaggaGaatggaagtctttggctaag	12	10	12	7	1	1	1	0	0	1	1	2	4	2	2	1	3	2	3	1	3	5	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr3:183381346G>C	uc003flv.2	+	4	1316	c.1021G>C	c.(1021-1023)GAA>CAA	p.E341Q	KLHL24_uc003flw.2_Missense_Mutation_p.E341Q|KLHL24_uc003flx.2_Missense_Mutation_p.E341Q	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	341	Kelch 1.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			TGTAACAGGAGAATGGAAGTC	0.413													5	111					0	0	0	0	C	183381346	C	C	183381346	3	2	77	1	0	0	0	0	1	0	0	0	8418	943	33	2	1027	2	KLHL24	3	183381346	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	12452374	183381346	14641084	43	15388											
ATP13A4	84239	broad.mit.edu	37	chr3	193166066	193166066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttttgtctcttccttcaatCgattctccaagatcagcagc	8	15	6	12	1	4	1	2	0	2	1	8	2	5	1	2	0	2	2	2	0	2	5	rs144335118		TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr3:193166066C>T	uc003ftd.2	-	18	2189	c.2081G>A	c.(2080-2082)CGA>CAA	p.R694Q	ATP13A4_uc003fte.1_Missense_Mutation_p.R694Q|ATP13A4_uc011bsr.1_Missense_Mutation_p.R165Q|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	694	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TTCCTTCAATCGATTCTCCAA	0.393													13	108					0	0	0	0	T	193166066	T	T	193166066	3	4	77	1	0	0	0	0	1	0	0	0	1128	884	31	1	1561	1	ATP13A4	3	193166066	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	9784720	193166066	4856364	44	15389											
FGFRL1	53834	broad.mit.edu	37	chr4	1017629	1017629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	accgcgcttcacacagccctCcaagatgaggcgccgggtga	9	5	12	15	4	1	3	1	2	0	1	2	3	2	3	4	2	1	1	4	2	1	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr4:1017629C>T	uc003gce.2	+	5	619	c.458C>T	c.(457-459)TCC>TTC	p.S153F	FGFRL1_uc003gcf.2_Missense_Mutation_p.S153F|FGFRL1_uc003gcg.2_Missense_Mutation_p.S153F|FGFRL1_uc010ibo.2_Missense_Mutation_p.S153F	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	153	Extracellular (Potential).|Ig-like C2-type 2.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ACACAGCCCTCCAAGATGAGG	0.711													4	8					0	0	0	0	T	1017629	T	T	1017629	3	4	77	1	0	0	0	0	1	0	0	0	5901	855	30	2	472	2	FGFRL1	4	1017629	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08		1017629	190136647	45	15390											
HTT	3064	broad.mit.edu	37	chr4	3201579	3201579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccatgatcaccacccaccCggccctggtgctgctctggt	5	10	9	17	1	2	1	1	1	1	0	3	1	3	1	5	3	2	2	5	3	0	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr4:3201579C>T	uc011bvq.1	+	42	5640	c.5495C>T	c.(5494-5496)CCG>CTG	p.P1832L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1830					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		ACCACCCACCCGGCCCTGGTG	0.587													7	46					0	0	0	0	T	3201579	T	T	3201579	3	4	77	1	0	0	0	0	1	0	0	0	7496	652	23	1	5651	1	HTT	4	3201579	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	2183950	3201579	187952697	46	15391											
UGT2B15	7366	broad.mit.edu	37	chr4	69513072	69513072	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggttggtcatgatgaattCttgataatttcatgacattc	10	18	8	5	0	3	4	2	4	1	0	4	4	3	4	0	2	0	1	0	2	2	7			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr4:69513072C>A	uc011cal.1	-	6	1381	c.1343G>T	c.(1342-1344)AGA>ATA	p.R448I		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	448					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						ATGATGAATTCTTGATAATTT	0.383													6	118					0.000157383	0.000165023	1	0	A	69513072	A	A	69513072	3	1	77	1	0	0	0	0	1	0	0	0	17026	913	32	2	1870	2	UGT2B15	4	69513072	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	66311493	69513072	121641204	47	15392											
UGT2B11	10720	broad.mit.edu	37	chr4	70080064	70080064	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaactacatctttacagAagtttctaaatatgtcatat	15	16	4	6	0	3	2	1	1	2	1	3	2	3	2	0	0	3	1	0	0	8	8			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr4:70080064A>T	uc003heh.2	-	1	386	c.377T>A	c.(376-378)TTC>TAC	p.F126Y	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	126					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						ATCTTTACAGAAGTTTCTAAA	0.333													12	79					0	0	0	0	T	70080064	T	T	70080064	3	4	77	1	0	0	0	0	1	0	0	0	17025	246	9	5	1236	5	UGT2B11	4	70080064	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	566992	70080064	121074212	48	15393											
CCDC158	339965	broad.mit.edu	37	chr4	77276585	77276585	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatccccattgccactttCatagctggaaaaaaaaaaga	16	9	6	10	0	1	1	1	0	0	1	2	2	2	2	3	1	3	2	3	1	6	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr4:77276585C>A	uc003hkb.3	-	14	2331	c.2178G>T	c.(2176-2178)ATG>ATT	p.M726I		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	726	Potential.									skin(3)|ovary(2)|pancreas(1)	6						TTGCCACTTTCATAGCTGGAA	0.383													31	110					1.80694e-10	2.05421e-10	1	0	A	77276585	A	A	77276585	3	1	77	1	0	0	0	0	1	0	0	0	2803	826	29	2	1207	2	CCDC158	4	77276585	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	7196521	77276585	113877691	49	15394											
PTPN13	5783	broad.mit.edu	37	chr4	87691069	87691069	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acagccagcagcagaaagtgGaaaaattgatgtaggagatg	17	6	13	5	0	0	3	0	1	0	2	0	5	0	4	1	2	3	3	1	2	4	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr4:87691069G>C	uc003hpz.2	+	29	5117	c.4637G>C	c.(4636-4638)GGA>GCA	p.G1546A	PTPN13_uc003hpy.2_Missense_Mutation_p.G1551A|PTPN13_uc003hqa.2_Missense_Mutation_p.G1527A|PTPN13_uc003hqb.2_Missense_Mutation_p.G1355A|PTPN13_uc003hqc.1_5'UTR	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1546	PDZ 3.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		GCAGAAAGTGGAAAAATTGAT	0.408													7	98					0	0	0	0	C	87691069	C	C	87691069	3	2	77	1	0	0	0	0	1	0	0	0	12845	1174	41	2	4762	2	PTPN13	4	87691069	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	10414484	87691069	103463207	50	15395											
SPOCK3	50859	broad.mit.edu	37	chr4	167658711	167658711	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacactgccatgacattgtgTtggcttgtagtaaccatctt	10	14	8	9	0	1	1	0	1	1	0	1	1	1	1	2	1	3	4	2	1	3	6			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr4:167658711T>A	uc003iri.1	-	11	1189	c.1048A>T	c.(1048-1050)ACA>TCA	p.T350S	SPOCK3_uc011cjp.1_Missense_Mutation_p.T307S|SPOCK3_uc011cjq.1_Missense_Mutation_p.T359S|SPOCK3_uc011cjr.1_Missense_Mutation_p.T230S|SPOCK3_uc003irj.1_Missense_Mutation_p.T347S|SPOCK3_uc011cjs.1_Missense_Mutation_p.T299S|SPOCK3_uc011cjt.1_Missense_Mutation_p.T258S|SPOCK3_uc011cju.1_Missense_Mutation_p.T243S|SPOCK3_uc011cjv.1_Missense_Mutation_p.T252S	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	350	Thyroglobulin type-1.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		TGACATTGTGTTGGCTTGTAG	0.423													32	109					0	0	0	0	A	167658711	A	A	167658711	3	1	77	1	0	0	0	0	1	0	0	0	15147	1725	60	5	270	5	SPOCK3	4	167658711	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	79967642	167658711	23495565	51	15396											
GPM6A	2823	broad.mit.edu	37	chr4	176573064	176573064	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggtccacagattgaagtaCatgtaaactggcagtgaggt	13	10	12	6	0	0	3	0	2	0	1	1	3	1	3	1	3	2	3	1	3	4	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr4:176573064C>G	uc003iuf.2	-	4	1266	c.462G>C	c.(460-462)ATG>ATC	p.M154I	GPM6A_uc011ckj.1_Missense_Mutation_p.M147I|GPM6A_uc003iug.2_Missense_Mutation_p.M154I|GPM6A_uc003iuh.2_Missense_Mutation_p.M143I	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	154	Extracellular (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		GATTGAAGTACATGTAAACTG	0.458													3	49					0	0	0	0	G	176573064	G	G	176573064	3	3	77	1	0	0	0	0	1	0	0	0	6653	478	17	4	390	4	GPM6A	4	176573064	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	8914353	176573064	14581212	52	15397											
ASB5	140458	broad.mit.edu	37	chr4	177190237	177190237	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ataattgttgagcaaacggcCgattttcttctaacaccgac	12	12	7	10	3	2	1	0	1	2	0	2	3	2	1	2	1	3	2	2	1	3	7			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr4:177190237C>T	uc003iuq.1	-	1	39	c.23G>A	c.(22-24)CGG>CAG	p.R8Q		NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	8					intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		AGCAAACGGCCGATTTTCTTC	0.448													8	53					0	0	0	0	T	177190237	T	T	177190237	3	4	77	1	0	0	0	0	1	0	0	0	1028	652	23	1	994	1	ASB5	4	177190237	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	617173	177190237	13964039	53	15398											
SLC12A7	10723	broad.mit.edu	37	chr5	1057669	1057669	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgatcagcttctccctggtCcaggtcatctgcaccttgtc	5	12	9	15	1	4	0	2	0	2	0	7	1	5	0	3	2	2	2	3	2	0	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr5:1057669C>A	uc003jbu.2	-	22	3009	c.2943G>T	c.(2941-2943)TGG>TGT	p.W981C		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	981	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	TCTCCCTGGTCCAGGTCATCT	0.617													11	204					1.58986e-06	1.7521e-06	1	0	A	1057669	A	A	1057669	3	1	77	1	0	0	0	0	1	0	0	0	14453	856	30	2	320	2	SLC12A7	5	1057669	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08		1057669	179857591	54	15399											
DNAH5	1767	broad.mit.edu	37	chr5	13891111	13891111	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttggagaaactcttcacAggttagtggctcctcctggg	8	12	11	10	0	2	1	1	0	1	1	4	2	4	1	2	4	1	2	2	4	2	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr5:13891111A>T	uc003jfd.2	-	17	2593	c.2551T>A	c.(2551-2553)TGT>AGT	p.C851S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	851	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AACTCTTCACAGGTTAGTGGC	0.393									Kartagener_syndrome				10	152					0	0	0	0	T	13891111	T	T	13891111	3	4	77	1	0	0	0	0	1	0	0	0	4626	188	7	5	11575	5	DNAH5	5	13891111	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	12833442	13891111	167024149	55	15400											
CDH10	1008	broad.mit.edu	37	chr5	24492957	24492957	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtactgtgaagtttggattGacagcagctaaactgaaaaa	15	11	10	5	0	0	3	0	3	0	0	0	4	0	4	0	1	4	4	0	1	6	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr5:24492957G>C	uc003jgr.1	-	10	1925	c.1593C>G	c.(1591-1593)GTC>GTG	p.V531V	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	531	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AGTTTGGATTGACAGCAGCTA	0.333										HNSCC(23;0.051)			7	197					0	0	0	0	C	24492957	C	C	24492957	2	2	77	1	0	0	0	0	0	0	0	1	3111	1277	45	2		2	CDH10	5	24492957	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	10601846	24492957	156422303	56	15401											
NUP155	9631	broad.mit.edu	37	chr5	37331895	37331895	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agtttatgaaacataaggctCccctaagaaatttgaagaaa	18	10	7	6	0	0	4	0	2	0	2	1	4	1	4	2	1	1	2	2	1	7	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr5:37331895C>G	uc003jku.1	-	14	1639	c.1521G>C	c.(1519-1521)GGG>GGC	p.G507G	NUP155_uc003jkt.1_Silent_p.G448G|NUP155_uc010iuz.1_Silent_p.G507G	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	507					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACATAAGGCTCCCCTAAGAAA	0.343													6	65					0	0	0	0	G	37331895	G	G	37331895	2	3	77	1	0	0	0	0	0	0	0	1	10810	842	30	2		2	NUP155	5	37331895	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	12838938	37331895	143583365	57	15402											
ACOT12	134526	broad.mit.edu	37	chr5	80667569	80667569	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgaaaaggtgcctcttacCtccatgcttgtgctgaatgc	8	14	9	10	0	1	2	0	2	1	0	2	2	2	2	3	1	5	2	3	1	4	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr5:80667569C>A	uc003khl.3	-	3	313	c.258G>T	c.(256-258)GAG>GAT	p.E86D	RNU5E_uc011cto.1_Intron|ACOT12_uc003khm.2_Missense_Mutation_p.E86D	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	86	Acyl coenzyme A hydrolase 1.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		TGCCTCTTACCTCCATGCTTG	0.398													19	52					1.9806e-07	2.21663e-07	1	0	A	80667569	A	A	80667569	3	1	77	1	0	0	0	0	1	0	0	0	150	695	24	4	1461	4	ACOT12	5	80667569	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	43335674	80667569	100247691	58	15403											
APC	324	broad.mit.edu	37	chr5	112174376	112174376	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atacaccaataaattatagtCttaaatattcagatgagcag	18	12	5	6	0	2	2	1	1	1	1	2	2	2	2	1	0	2	1	1	0	9	7			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr5:112174376C>A	uc010jby.2	+	16	3465	c.3085C>A	c.(3085-3087)CTT>ATT	p.L1029I	APC_uc011cvt.1_Missense_Mutation_p.L1011I|APC_uc003kpz.3_Missense_Mutation_p.L1029I|APC_uc003kpy.3_Missense_Mutation_p.L1029I|APC_uc010jbz.2_Missense_Mutation_p.L746I|APC_uc010jca.2_Missense_Mutation_p.L329I	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1029	Ser-rich.|Responsible for down-regulation through a process mediated by direct ubiquitination.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AAATTATAGTCTTAAATATTC	0.363		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			5	65					0.00116845	0.00120183	1	0	A	112174376	A	A	112174376	3	1	77	1	0	0	0	0	1	0	0	0	763	913	32	2	3143	2	APC	5	112174376	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	31506807	112174376	68740884	59	15404											
IL13	3596	broad.mit.edu	37	chr5	131993989	131993989	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgcctccccaggccctgtGcctccctctacagccctcag	4	10	7	20	0	2	0	1	0	1	0	4	0	4	0	7	1	4	0	7	1	1	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr5:131993989G>T	uc003kxj.1	+	1	125	c.111G>T	c.(109-111)GTG>GTT	p.V37V		NM_002188	NP_002179	P35225	IL13_HUMAN	interleukin 13 precursor	37					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			ovary(1)|skin(1)	2		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGGCCCTGTGCCTCCCTCTA	0.592													10	28					0.000442599	0.000459622	1	0	T	131993989	T	T	131993989	2	4	77	1	0	0	0	0	0	0	0	1	7667	1306	46	4		4	IL13	5	131993989	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	19819613	131993989	48921271	60	15405											
PCDHA6	56142	broad.mit.edu	37	chr5	140207691	140207691	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgacatggtgtttaccccGgaggatagattgggaaagca	11	11	13	6	1	0	2	0	1	0	1	0	5	0	5	2	4	2	2	2	4	3	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr5:140207691G>A	uc003lho.2	+	1	42	c.15G>A	c.(13-15)CCG>CCA	p.P5P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.P5P|PCDHA6_uc011dab.1_Silent_p.P5P	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	5					homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTTACCCCGGAGGATAGAT	0.478													20	121					0	0	0	0	A	140207691	A	A	140207691	2	1	77	1	0	0	0	0	0	0	0	1	11582	1103	39	1		1	PCDHA6	5	140207691	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	8213702	140207691	40707569	61	15406											
LARP1	23367	broad.mit.edu	37	chr5	154179273	154179273	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgatttctcccagcttctCaactgccctgaatttgttcc	7	15	5	14	0	2	2	1	2	2	0	5	2	3	2	3	0	3	2	3	0	2	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr5:154179273C>T	uc003lvp.2	+	9	1929	c.1500C>T	c.(1498-1500)CTC>CTT	p.L500L	LARP1_uc003lvo.2_Silent_p.L423L|LARP1_uc010jie.1_Silent_p.L295L	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	500							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CCCAGCTTCTCAACTGCCCTG	0.502													9	88					0	0	0	0	T	154179273	T	T	154179273	2	4	77	1	0	0	0	0	0	0	0	1	8668	813	29	2		2	LARP1	5	154179273	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	13971582	154179273	26735987	62	15407											
PRPH2	5961	broad.mit.edu	37	chr6	42689520	42689520	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctttggaggaaaagtccaGgtagcgattgctgatccact	10	12	11	8	1	1	1	0	1	1	0	3	4	3	3	2	3	2	2	2	3	3	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr6:42689520G>A	uc003osk.2	-	1	839	c.553C>T	c.(553-555)CTG>TTG	p.L185L		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	185	Lumenal (Potential).		L -> P (in RP7; in combination with a null mutation of ROM1).		cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			GAAAAGTCCAGGTAGCGATTG	0.502													24	141					0	0	0	0	A	42689520	A	A	42689520	2	1	77	1	0	0	0	0	0	0	0	1	12639	991	35	4		4	PRPH2	6	42689520	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08		42689520	128425547	63	15408											
AARS2	57505	broad.mit.edu	37	chr6	44279951	44279951	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgttggccacacgtcggaagCctgccatctcgcttcgtgga	6	10	12	13	4	1	0	0	0	1	0	4	2	1	2	3	3	2	2	3	3	1	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr6:44279951C>T	uc010jza.1	-	2	296	c.293G>A	c.(292-294)GGC>GAC	p.G98D	SPATS1_uc003oxg.2_Intron	NM_020745	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	98					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			ovary(1)	1	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	ACGTCGGAAGCCTGCCATCTC	0.527													13	56					0	0	0	0	T	44279951	T	T	44279951	3	4	77	1	0	0	0	0	1	0	0	0	20	739	26	4	2748	4	AARS2	6	44279951	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	1590431	44279951	126835116	64	15409											
DDX43	55510	broad.mit.edu	37	chr6	74104706	74104707	+	Missense_Mutation	DNP	GC	TA	TA																															agctcgacagtgtcccgagcGccagagaggaggccggcgga																										TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr6:74104706_74104707GC>TA	uc003pgw.2	+	1	422_423	c.78_79GC>TA	c.(76-81)GCGCCA>GCTACA	p.P27T	OOEP_uc003pgv.3_5'UTR|DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	27						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						TGTCCCGAGCGCCAGAGAGGAG	0.644													13	73					0	0	0	0	TA	74104707	TA	TA	74104706	3	4	77	1	0	0	0	0	1	0	0	0	4380	1074	38	3	80	3	DDX43	6	74104706	Missense_Mutation	DNP	GC	TCGA-CN-6020-01A-11D-1683-08	29824755	74104706	97010361	65	15410											
GOPC	57120	broad.mit.edu	37	chr6	117896462	117896462	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcaacaatttcacttcagcTtcaagttgtgcttctttcat	9	17	4	11	0	6	0	5	0	1	0	6	0	6	0	0	0	3	3	0	0	3	6			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr6:117896462T>C	uc003pxu.2	-	4	758	c.528A>G	c.(526-528)GAA>GAG	p.E176E	GOPC_uc003pxq.1_5'Flank|GOPC_uc003pxv.2_Silent_p.E168E	NM_020399	NP_065132	Q9HD26	GOPC_HUMAN	golgi associated PDZ and coiled-coil motif	176	Potential.				apical protein localization|cytoplasmic sequestering of CFTR protein|ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein homooligomerization|protein transport	cell junction|dendrite|Golgi membrane|postsynaptic density|postsynaptic membrane|trans-Golgi network transport vesicle	cystic fibrosis transmembrane conductance regulator binding			ovary(1)	1		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)		TCACTTCAGCTTCAAGTTGTG	0.348			O	ROS1	glioblastoma								6	34					0	0	0	0	C	117896462	C	C	117896462	2	2	77	1	0	0	0	0	0	0	0	1	6610	1606	56	5		5	GOPC	6	117896462	Silent	SNP	T	TCGA-CN-6020-01A-11D-1683-08	43791756	117896462	53218605	66	15411											
SMPDL3A	10924	broad.mit.edu	37	chr6	123124975	123124975	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactctcagcagaataaggaGaaggtagatcccatagacca	17	6	9	9	0	1	4	1	0	1	4	3	5	2	4	2	2	2	2	2	2	6	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr6:123124975G>C	uc003pzg.2	+	5	1256	c.735G>C	c.(733-735)GAG>GAC	p.E245D	SMPDL3A_uc003pzh.2_Missense_Mutation_p.E114D	NM_006714	NP_006705	Q92484	ASM3A_HUMAN	acid sphingomyelinase-like phosphodiesterase 3A	245					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|protein binding|sphingomyelin phosphodiesterase activity				0				GBM - Glioblastoma multiforme(226;0.236)		AGAATAAGGAGAAGGTAGATC	0.393													15	74					0	0	0	0	C	123124975	C	C	123124975	3	2	77	1	0	0	0	0	1	0	0	0	14872	933	33	2	753	2	SMPDL3A	6	123124975	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	5228513	123124975	47990092	67	15412											
SUN1	23353	broad.mit.edu	37	chr7	883110	883110	+	Frame_Shift_Del	DEL	C	-	-																															gctcacggcgcaccccgcggCccccgggcccgtgtcgagag																										TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr7:883110delC	uc011jvp.1	+	6	690	c.611delC	c.(610-612)GCCfs	p.A204fs	SUN1_uc010ksa.1_Frame_Shift_Del_p.A225fs|SUN1_uc003sje.1_Frame_Shift_Del_p.A204fs|SUN1_uc003sjf.2_Frame_Shift_Del_p.A154fs|SUN1_uc011jvq.1_Intron|SUN1_uc003sjg.2_Frame_Shift_Del_p.A15fs	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	204	Nuclear.			A -> P (in Ref. 5; AAH13613).	cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						CACCCCGCGGCCCCCGGGCCC	0.557													---	---	---								-	883110	-	-	883110	7	5	77	1	0	1	0	1	0	0	0	0	15457	739	26	0	696	0	SUN1	7	883110	Frame_Shift_Del	DEL	C	TCGA-CN-6020-01A-11D-1683-08		883110	158255553	68	15413											
AMZ1	155185	broad.mit.edu	37	chr7	2740214	2740214	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcccctgccgagcggctcttCctggccgaggcctacaaccc	5	7	10	19	3	1	0	0	0	1	0	3	2	3	0	7	3	4	1	7	3	2	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr7:2740214C>A	uc003smr.1	+	2	490	c.129C>A	c.(127-129)TTC>TTA	p.F43L	AMZ1_uc003sms.1_Missense_Mutation_p.F43L|AMZ1_uc011jwa.1_5'Flank	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	43							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		AGCGGCTCTTCCTGGCCGAGG	0.672													16	182					1.02788e-11	1.18097e-11	1	0	A	2740214	A	A	2740214	3	1	77	1	0	0	0	0	1	0	0	0	596	854	30	2	131	2	AMZ1	7	2740214	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	1857104	2740214	156398449	69	15414											
DGKB	1607	broad.mit.edu	37	chr7	14378214	14378214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acccttttttctctattcgtCgatggcttcgtcttttctta	4	21	5	11	3	3	0	0	0	3	0	7	1	3	0	1	1	0	1	1	1	2	9			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr7:14378214C>T	uc003ssz.2	-	22	2238	c.2051G>A	c.(2050-2052)CGA>CAA	p.R684Q	DGKB_uc011jxt.1_Missense_Mutation_p.R665Q|DGKB_uc003sta.2_Missense_Mutation_p.R684Q|DGKB_uc011jxu.1_Missense_Mutation_p.R683Q	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	684					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	CTCTATTCGTCGATGGCTTCG	0.393													4	89					0	0	0	0	T	14378214	T	T	14378214	3	4	77	1	0	0	0	0	1	0	0	0	4488	884	31	1	394	1	DGKB	7	14378214	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	11638000	14378214	144760449	70	15415											
RAPGEF5	9771	broad.mit.edu	37	chr7	22202079	22202079	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtacagagcaatccactggGaaacaagatgcaagacttta	16	8	9	8	0	0	3	0	0	0	3	1	4	1	4	1	1	4	3	1	1	6	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr7:22202079G>T	uc003svg.2	-	13	1218	c.905C>A	c.(904-906)TCC>TAC	p.S302Y	RAPGEF5_uc011jyl.1_5'UTR	NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	152	N-terminal Ras-GEF.				nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						AATCCACTGGGAAACAAGATG	0.368													4	63					2.56e-06	2.79273e-06	1	0	T	22202079	T	T	22202079	3	4	77	1	0	0	0	0	1	0	0	0	13112	1174	41	2	1343	2	RAPGEF5	7	22202079	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	7823865	22202079	136936584	71	15416											
TYW1B	441250	broad.mit.edu	37	chr7	72159743	72159743	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccttgaagagtgggcggtcGattttcttcaggctgtcttt	5	16	12	8	2	3	2	1	1	2	1	5	3	4	2	1	3	0	1	1	3	1	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr7:72159743G>A	uc011kej.1	-	14	1599	c.1440C>T	c.(1438-1440)ATC>ATT	p.I480I	TYW1B_uc011keh.1_Silent_p.I318I|TYW1B_uc011kei.1_Silent_p.I106I	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	480					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GTGGGCGGTCGATTTTCTTCA	0.388													8	68					0	0	0	0	A	72159743	A	A	72159743	2	1	77	1	0	0	0	0	0	0	0	1	16887	1048	37	1		1	TYW1B	7	72159743	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	49957664	72159743	86978920	72	15417											
PEX1	5189	broad.mit.edu	37	chr7	92138667	92138667	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagagctcagctttaaaaaaGgaagaataaagtcaatttcc	19	9	7	6	0	2	2	2	0	0	2	3	3	3	3	1	1	2	2	1	1	9	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr7:92138667G>A	uc003uly.2	-	9	1742	c.1646C>T	c.(1645-1647)CCT>CTT	p.P549L	PEX1_uc011khr.1_Missense_Mutation_p.P341L|PEX1_uc010ley.2_Missense_Mutation_p.P549L|PEX1_uc011khs.1_Missense_Mutation_p.P227L|PEX1_uc011kht.1_Intron	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	549					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CTTTAAAAAAGGAAGAATAAA	0.333													9	45					0	0	0	0	A	92138667	A	A	92138667	3	1	77	1	0	0	0	0	1	0	0	0	11790	1000	35	4	2269	4	PEX1	7	92138667	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	19978924	92138667	66999996	73	15418											
MUC17	140453	broad.mit.edu	37	chr7	100684155	100684155	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacaacttctgaaggtaccaGcatgccaacctcaactccta	13	9	5	14	0	2	1	1	1	1	0	3	1	3	1	4	1	7	2	4	1	7	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr7:100684155G>A	uc003uxp.1	+	3	9511	c.9458G>A	c.(9457-9459)AGC>AAC	p.S3153N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3153	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|51.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGGTACCAGCATGCCAACC	0.478													108	208					0	0	0	0	A	100684155	A	A	100684155	3	1	77	1	0	0	0	0	1	0	0	0	10027	971	34	4	9468	4	MUC17	7	100684155	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	8545488	100684155	58454508	74	15419											
KCND2	3751	broad.mit.edu	37	chr7	120385968	120385968	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgctgttcacgacgacaCaaaaaaacttttcgcatccc	13	9	5	14	3	1	0	1	0	0	0	3	2	2	0	2	0	2	3	2	0	3	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr7:120385968C>G	uc003vjj.1	+	5	2567	c.1602C>G	c.(1600-1602)CAC>CAG	p.H534Q		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	534	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					CACGACGACACAAAAAAACTT	0.448													7	55					0	0	0	0	G	120385968	G	G	120385968	3	3	77	1	0	0	0	0	1	0	0	0	8058	477	17	4	1620	4	KCND2	7	120385968	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	19701813	120385968	38752695	75	15420											
RP1L1	94137	broad.mit.edu	37	chr8	10469745	10469745	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtggaagaggctccttcCgagtcccaggagcaggaaag	10	5	17	9	1	0	1	0	0	0	1	3	5	3	4	3	6	1	2	3	6	2	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:10469745C>T	uc003wtc.2	-	4	2092	c.1863G>A	c.(1861-1863)TCG>TCA	p.S621S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	621					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGGCTCCTTCCGAGTCCCAGG	0.647													5	64					0	0	0	0	T	10469745	T	T	10469745	2	4	77	1	0	0	0	0	0	0	0	1	13598	639	23	1		1	RP1L1	8	10469745	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08		10469745	135894277	76	15421											
ADAM7	8756	broad.mit.edu	37	chr8	24324479	24324479	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttccaggggataatgaatCtgaagaagactccaaaataa	17	9	9	6	0	1	4	0	2	1	2	3	5	3	5	2	2	0	1	2	2	7	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:24324479C>G	uc003xeb.2	+	6	670	c.557C>G	c.(556-558)TCT>TGT	p.S186C	ADAM7_uc003xea.1_Missense_Mutation_p.S186C	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	186	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		GATAATGAATCTGAAGAAGAC	0.348													12	84					0	0	0	0	G	24324479	G	G	24324479	3	3	77	1	0	0	0	0	1	0	0	0	251	913	32	2	579	2	ADAM7	8	24324479	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	13854734	24324479	122039543	77	15422											
STAR	6770	broad.mit.edu	37	chr8	38003513	38003513	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctgctcaggcatgttcccGaagtctgtggccatgccagc	6	11	11	13	1	3	0	1	0	2	0	4	1	4	0	3	2	3	3	3	2	1	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:38003513G>A	uc003xkv.1	-	6	828	c.564C>T	c.(562-564)TTC>TTT	p.F188F	STAR_uc010lwc.1_Silent_p.F168F	NM_001007243	NP_001007244	P49675	STAR_HUMAN	steroidogenic acute regulatory protein isoform	206	START.				C21-steroid hormone biosynthetic process	mitochondrial intermembrane space	cholesterol transporter activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.0151)|Lung NSC(58;0.0295)		READ - Rectum adenocarcinoma(644;0.188)		GCATGTTCCCGAAGTCTGTGG	0.617													6	128					0	0	0	0	A	38003513	A	A	38003513	2	1	77	1	0	0	0	0	0	0	0	1	15320	1049	37	1		1	STAR	8	38003513	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	13679034	38003513	108360509	78	15423											
ADAM2	2515	broad.mit.edu	37	chr8	39626980	39626980	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacacactgcttgctgtttGaaaaaaggatctaagcgagg	13	9	10	9	1	1	1	0	1	1	0	1	3	1	2	1	2	3	3	1	2	4	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:39626980G>C	uc003xnj.2	-	12	1218	c.1143C>G	c.(1141-1143)TTC>TTG	p.F381L	ADAM2_uc003xnk.2_Missense_Mutation_p.F362L|ADAM2_uc011lck.1_Missense_Mutation_p.F381L|ADAM2_uc003xnl.2_Missense_Mutation_p.F255L	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	381	Extracellular (Potential).				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTTGCTGTTTGAAAAAAGGAT	0.443													3	52					0	0	0	0	C	39626980	C	C	39626980	3	2	77	1	0	0	0	0	1	0	0	0	241	1281	45	2	1100	2	ADAM2	8	39626980	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	1623467	39626980	106737042	79	15424											
HOOK3	84376	broad.mit.edu	37	chr8	42821703	42821703	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggcaacagaatgatgaactGaccactttggcagatgaagc	14	7	11	9	1	0	6	0	4	0	2	0	6	0	6	1	2	3	2	1	2	4	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:42821703G>C	uc003xpr.2	+	10	1109	c.867G>C	c.(865-867)CTG>CTC	p.L289L	HOOK3_uc010lxq.1_Silent_p.L289L	NM_032410	NP_115786	Q86VS8	HOOK3_HUMAN	golgi-associated microtubule-binding protein	289	Potential.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			ovary(1)|breast(1)	2	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			ATGATGAACTGACCACTTTGG	0.448			T	RET	papillary thyroid								4	89					0	0	0	0	C	42821703	C	C	42821703	2	2	77	1	0	0	0	0	0	0	0	1	7323	1277	45	2		2	HOOK3	8	42821703	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	3194723	42821703	103542319	80	15425											
PRKDC	5591	broad.mit.edu	37	chr8	48801649	48801649	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatctttagagctttcatCagattcacacaaacatcagg	14	11	6	10	0	5	2	4	0	1	2	5	3	5	2	0	1	2	1	0	1	2	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:48801649C>A	uc003xqi.2	-	34	4263	c.4206G>T	c.(4204-4206)CTG>CTT	p.L1402L	PRKDC_uc003xqj.2_Silent_p.L1402L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1402					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GAGCTTTCATCAGATTCACAC	0.483								NHEJ					6	60					0.00116845	0.00120183	1	0	A	48801649	A	A	48801649	2	1	77	1	0	0	0	0	0	0	0	1	12583	813	29	2		2	PRKDC	8	48801649	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	5979946	48801649	97562373	81	15426											
MCM4	4173	broad.mit.edu	37	chr8	48882491	48882491	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggccttgatgaagaagcAgaacagaaacttttttcaga	15	10	9	7	0	1	6	1	2	0	4	1	6	1	6	1	1	3	1	1	1	4	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:48882491A>C	uc003xqk.1	+	11	1403	c.1308A>C	c.(1306-1308)GCA>GCC	p.A436A	MCM4_uc003xql.1_Silent_p.A436A|MCM4_uc011ldi.1_Silent_p.A423A	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	436					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				ATGAAGAAGCAGAACAGAAAC	0.423													29	115					0	0	0	0	C	48882491	C	C	48882491	2	2	77	1	0	0	0	0	0	0	0	1	9442	175	7	5		5	MCM4	8	48882491	Silent	SNP	A	TCGA-CN-6020-01A-11D-1683-08	80842	48882491	97481531	82	15427											
RP1	6101	broad.mit.edu	37	chr8	55541982	55541982	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacctgtgccaaggaaagaaTagcaaatcatcatacagagg	18	6	9	8	0	2	2	2	0	0	2	2	3	2	3	2	2	4	1	2	2	7	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:55541982T>C	uc003xsd.1	+	4	5688	c.5540T>C	c.(5539-5541)ATA>ACA	p.I1847T	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1847					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGGAAAGAATAGCAAATCAT	0.408													18	43					0	0	0	0	C	55541982	C	C	55541982	3	2	77	1	0	0	0	0	1	0	0	0	13597	1406	49	5	5550	5	RP1	8	55541982	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	6659491	55541982	90822040	83	15428											
MATN2	4147	broad.mit.edu	37	chr8	99006720	99006720	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgccagagatagactactGtgcctcatctaatcacggat	11	11	8	11	1	3	2	2	0	1	2	3	4	3	3	2	1	3	0	2	1	3	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:99006720G>T	uc003yic.2	+	7	1325	c.1094G>T	c.(1093-1095)TGT>TTT	p.C365F	MATN2_uc003yib.1_Missense_Mutation_p.C365F|MATN2_uc010mbh.1_Intron|MATN2_uc003yid.2_Missense_Mutation_p.C365F|MATN2_uc003yie.1_Missense_Mutation_p.C365F|MATN2_uc010mbi.1_Missense_Mutation_p.C198F	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	365	EGF-like 4.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			ATAGACTACTGTGCCTCATCT	0.423													45	157					1.02067e-35	1.1917e-35	1	0	T	99006720	T	T	99006720	3	4	77	1	0	0	0	0	1	0	0	0	9387	1377	48	4	1116	4	MATN2	8	99006720	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	43464738	99006720	47357302	84	15429											
COL14A1	7373	broad.mit.edu	37	chr8	121216036	121216036	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgttgccgaattcgatctGatgcacacagttgtggagag	11	11	12	7	2	1	2	0	1	1	1	2	5	1	2	1	1	2	3	1	1	2	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:121216036G>A	uc003yox.2	+	9	1231	c.966G>A	c.(964-966)CTG>CTA	p.L322L	COL14A1_uc003yoy.2_5'UTR|COL14A1_uc010mde.1_5'UTR	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	322	VWFA 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AATTCGATCTGATGCACACAG	0.483													4	42					0	0	0	0	A	121216036	A	A	121216036	2	1	77	1	0	0	0	0	0	0	0	1	3686	1277	45	2		2	COL14A1	8	121216036	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	22209316	121216036	25147986	85	15430											
ZNF623	9831	broad.mit.edu	37	chr8	144732947	144732947	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgggaaggcattccgtcAtcgctcagaccttattgaac	10	11	10	10	2	2	2	2	1	0	1	4	3	3	3	2	2	1	2	2	2	3	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:144732947A>T	uc003yzd.2	+	1	994	c.905A>T	c.(904-906)CAT>CTT	p.H302L	ZNF623_uc011lkp.1_Missense_Mutation_p.H262L|ZNF623_uc003yzc.2_Missense_Mutation_p.H262L	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	302	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCATTCCGTCATCGCTCAGAC	0.453													13	47					0	0	0	0	T	144732947	T	T	144732947	3	4	77	1	0	0	0	0	1	0	0	0	18114	217	8	5	907	5	ZNF623	8	144732947	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	23516911	144732947	1631075	86	15431											
CPSF1	29894	broad.mit.edu	37	chr8	145621932	145621932	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatggctttggcttcttctCacggaagttgatgttgtgag	6	15	14	6	1	2	2	1	2	2	0	3	4	2	4	0	4	0	4	0	4	1	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr8:145621932C>A	uc003zcj.2	-	25	2782	c.2707G>T	c.(2707-2709)GAG>TAG	p.E903*		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	903	Nuclear localization signal (Potential).				mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GGCTTCTTCTCACGGAAGTTG	0.642													33	99					8.16277e-20	9.42866e-20	1	0	A	145621932	A	A	145621932	4	1	77	1	0	0	0	0	0	1	0	0	3839	835	29	2	1680	2	CPSF1	8	145621932	Nonsense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	888985	145621932	742090	87	15432											
ELAVL2	1993	broad.mit.edu	37	chr9	23731115	23731115	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttcacaaagccatatcccaAgctctgccctaatgaaaagg	14	8	7	12	0	2	1	1	1	1	0	3	1	3	1	3	1	3	2	3	1	6	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr9:23731115A>T	uc003zpu.2	-	3	513	c.238T>A	c.(238-240)TTG>ATG	p.L80M	ELAVL2_uc003zps.2_Missense_Mutation_p.L80M|ELAVL2_uc003zpt.2_Missense_Mutation_p.L80M|ELAVL2_uc003zpv.2_Missense_Mutation_p.L80M|ELAVL2_uc003zpw.2_Missense_Mutation_p.L80M	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	80	RRM 1.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CCATATCCCAAGCTCTGCCCT	0.383													8	18					0	0	0	0	T	23731115	T	T	23731115	3	4	77	1	0	0	0	0	1	0	0	0	5074	69	3	5	861	5	ELAVL2	9	23731115	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08		23731115	117482316	88	15433											
FRMPD1	22844	broad.mit.edu	37	chr9	37735705	37735705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctgagaaagtgagcgtcGtcaaagtgtatcttcaggac	12	10	12	7	2	4	2	2	2	2	1	5	4	4	3	0	1	1	1	0	1	3	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr9:37735705G>A	uc004aag.1	+	13	1419	c.1375G>A	c.(1375-1377)GTC>ATC	p.V459I	FRMPD1_uc004aah.1_Missense_Mutation_p.V459I|FRMPD1_uc011lqm.1_Missense_Mutation_p.V281I|FRMPD1_uc011lqn.1_Missense_Mutation_p.V328I	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	459	FERM.					cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		AGTGAGCGTCGTCAAAGTGTA	0.453													7	29					0	0	0	0	A	37735705	A	A	37735705	3	1	77	1	0	0	0	0	1	0	0	0	6091	1145	40	1	1421	1	FRMPD1	9	37735705	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	14004590	37735705	103477726	89	15434											
KIAA0368	23392	broad.mit.edu	37	chr9	114173379	114173379	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagccaaataccttcccaccGtgaatcccaatgcaagcaag	14	7	6	14	1	0	1	0	1	0	0	2	1	2	1	5	0	4	2	5	0	7	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr9:114173379G>A	uc004bfe.1	-	23	2792	c.2792C>T	c.(2791-2793)ACG>ATG	p.T931M		NM_001080398	NP_001073867			KIAA0368 protein												0						CCTTCCCACCGTGAATCCCAA	0.438													5	196					0	0	0	0	A	114173379	A	A	114173379	3	1	77	1	0	0	0	0	1	0	0	0	8210	1145	40	1	3377	1	KIAA0368	9	114173379	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	76437674	114173379	27040052	90	15435											
AMBP	259	broad.mit.edu	37	chr9	116823281	116823281	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgttgccctggcagcccccGtaggggaagaggacgcactt	7	6	14	14	3	0	1	0	0	0	1	0	3	0	3	4	4	2	4	4	4	2	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr9:116823281G>A	uc004bie.3	-	9	1214	c.951C>T	c.(949-951)TAC>TAT	p.Y317Y	AMBP_uc011lxk.1_3'UTR	NM_001633	NP_001624	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin preproprotein	317	BPTI/Kunitz inhibitor 2.				cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			skin(1)	1					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	GGCAGCCCCCGTAGGGGAAGA	0.622													6	105					0	0	0	0	A	116823281	A	A	116823281	2	1	77	1	0	0	0	0	0	0	0	1	564	1140	40	1		1	AMBP	9	116823281	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	2649902	116823281	24390150	91	15436											
MLLT10	8028	broad.mit.edu	37	chr10	22022748	22022748	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctcatcagctctttctaccCcacctcctgctgggcagagt	6	11	8	16	0	4	1	2	0	2	1	5	1	5	1	4	1	3	4	4	1	1	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr10:22022748C>T	uc001iqs.2	+	21	2944	c.2596C>T	c.(2596-2598)CCA>TCA	p.P866S	MLLT10_uc001iqt.2_Missense_Mutation_p.P850S|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.P850S|MLLT10_uc001ira.2_Missense_Mutation_p.P307S|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	866					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						TCTTTCTACCCCACCTCCTGC	0.527			T	MLL|PICALM|CDK6	AL								11	35					0	0	0	0	T	22022748	T	T	22022748	3	4	77	1	0	0	0	0	1	0	0	0	9679	623	22	4	2674	4	MLLT10	10	22022748	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08		22022748	113511999	92	15437											
CSGALNACT2	55454	broad.mit.edu	37	chr10	43678751	43678751	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagaagatgttcatctttatCgaaaatacttacatggtgac	14	13	8	6	1	2	3	1	1	1	2	3	5	2	3	0	1	2	1	0	1	6	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr10:43678751C>T	uc001jan.2	+	8	1725	c.1390C>T	c.(1390-1392)CGA>TGA	p.R464*		NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	464	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						TCATCTTTATCGAAAATACTT	0.438													6	132					0	0	0	0	T	43678751	T	T	43678751	4	4	77	1	0	0	0	0	0	1	0	0	3956	876	31	1	1416	1	CSGALNACT2	10	43678751	Nonsense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	21656003	43678751	91855996	93	15438											
PRKG1	5592	broad.mit.edu	37	chr10	54053631	54053631	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgatgaaccaccacctgatGacaactcaggatgggatata	15	7	9	10	1	1	3	1	3	0	0	1	6	1	5	3	2	2	0	3	2	4	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr10:54053631G>C	uc001jjm.2	+	18	2181	c.1987G>C	c.(1987-1989)GAC>CAC	p.D663H	PRKG1_uc001jjo.2_Missense_Mutation_p.D678H|PRKG1_uc009xow.1_Missense_Mutation_p.D381H|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	663	AGC-kinase C-terminal.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		ACCACCTGATGACAACTCAGG	0.433													8	60					0	0	0	0	C	54053631	C	C	54053631	3	2	77	1	0	0	0	0	1	0	0	0	12584	1290	45	2	2372	2	PRKG1	10	54053631	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	10374880	54053631	81481116	94	15439											
LRIT2	340745	broad.mit.edu	37	chr10	85984686	85984686	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagttctggcaggtgttccaGggctcctaggtggatcacac	7	10	13	11	0	2	0	1	0	1	0	4	1	4	1	2	5	0	4	2	5	1	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr10:85984686G>T	uc001kcy.2	-	2	303	c.295C>A	c.(295-297)CTG>ATG	p.L99M	LRIT2_uc010qmc.1_Missense_Mutation_p.L99M	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	99	LRR 1.					integral to membrane				ovary(2)	2						AGGTGTTCCAGGGCTCCTAGG	0.522													10	136					2.17888e-05	2.32989e-05	1	0	T	85984686	T	T	85984686	3	4	77	1	0	0	0	0	1	0	0	0	8998	991	35	4	1365	4	LRIT2	10	85984686	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	31931055	85984686	49550061	95	15440											
HELLS	3070	broad.mit.edu	37	chr10	96333910	96333910	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttcactggaggagtgatgcGatggtaccaagtagaaggca	12	8	14	7	1	1	2	1	1	0	1	1	5	1	4	1	4	2	3	1	4	4	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr10:96333910G>A	uc001kjt.2	+	8	776	c.671G>A	c.(670-672)CGA>CAA	p.R224Q	HELLS_uc001kjs.2_Missense_Mutation_p.R208Q|HELLS_uc009xul.2_Missense_Mutation_p.R224Q|HELLS_uc009xum.2_Missense_Mutation_p.R224Q|HELLS_uc009xun.2_Missense_Mutation_p.R100Q|HELLS_uc009xuo.2_Missense_Mutation_p.R224Q|HELLS_uc001kju.2_5'UTR|HELLS_uc009xup.2_RNA|HELLS_uc009xuq.2_Missense_Mutation_p.R86Q|HELLS_uc009xur.2_RNA	NM_018063	NP_060533	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	224					cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		GGAGTGATGCGATGGTACCAA	0.393													5	92					0	0	0	0	A	96333910	A	A	96333910	3	1	77	1	0	0	0	0	1	0	0	0	7085	1058	37	1	701	1	HELLS	10	96333910	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	10349224	96333910	39200837	96	15441											
CYP2C8	1558	broad.mit.edu	37	chr10	96827015	96827015	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgagcttcctcttgaacaCggtcctcaatgctcctcttc	7	13	7	14	1	3	2	1	2	2	0	7	2	6	2	3	1	3	2	3	1	2	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr10:96827015C>T	uc001kkb.2	-	3	526	c.431G>A	c.(430-432)CGT>CAT	p.R144H	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.R74H|CYP2C8_uc010qob.1_Missense_Mutation_p.R58H|CYP2C8_uc010qoc.1_Missense_Mutation_p.R42H|CYP2C8_uc010qod.1_Missense_Mutation_p.R58H	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	144					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	CTCTTGAACACGGTCCTCAAT	0.498													41	100					0	0	0	0	T	96827015	T	T	96827015	3	4	77	1	0	0	0	0	1	0	0	0	4184	536	19	1	1069	1	CYP2C8	10	96827015	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	493105	96827015	38707732	97	15442											
CCDC147	159686	broad.mit.edu	37	chr10	106160509	106160509	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagttagctttgctctatgaGaagatcaagatccaacagtc	13	11	9	8	0	2	3	1	1	1	3	4	5	3	3	1	0	3	3	1	0	5	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr10:106160509G>C	uc001kyh.2	+	13	2021	c.1887G>C	c.(1885-1887)GAG>GAC	p.E629D		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	629										ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		TGCTCTATGAGAAGATCAAGA	0.488													11	60					0	0	0	0	C	106160509	C	C	106160509	3	2	77	1	0	0	0	0	1	0	0	0	2793	933	33	2	1937	2	CCDC147	10	106160509	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	9333494	106160509	29374238	98	15443											
MKI67	4288	broad.mit.edu	37	chr10	129905202	129905202	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccactttccccagggatgtCttgagccgtcgcttggagct	5	11	11	14	2	1	1	0	1	1	0	3	3	2	3	4	2	2	2	4	2	0	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr10:129905202C>G	uc001lke.2	-	13	5097	c.4902G>C	c.(4900-4902)AAG>AAC	p.K1634N	MKI67_uc001lkf.2_Missense_Mutation_p.K1274N|MKI67_uc009yav.1_Missense_Mutation_p.K1209N|MKI67_uc009yaw.1_Missense_Mutation_p.K784N	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1634	6.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CCAGGGATGTCTTGAGCCGTC	0.502													8	177					0	0	0	0	G	129905202	G	G	129905202	3	3	77	1	0	0	0	0	1	0	0	0	9651	912	32	2	4880	2	MKI67	10	129905202	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	23744693	129905202	5629545	99	15444											
EBF3	253738	broad.mit.edu	37	chr10	131640443	131640443	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggctgctgaaggagttgaCgcccatcatgcccgtgtgtg	6	10	14	11	2	1	2	1	2	0	0	1	3	1	3	2	2	2	3	2	2	1	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr10:131640443C>T	uc001lki.1	-	13	1341	c.1282G>A	c.(1282-1284)GTC>ATC	p.V428I		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	437					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AAGGAGTTGACGCCCATCATG	0.627													15	102					0	0	0	0	T	131640443	T	T	131640443	3	4	77	1	0	0	0	0	1	0	0	0	4904	536	19	1	389	1	EBF3	10	131640443	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	1735241	131640443	3894304	100	15445											
MTG1	92170	broad.mit.edu	37	chr10	135233650	135233650	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcctgcggggccacccccCggctgagactttgccctgaa	5	7	12	17	3	0	2	0	2	0	1	1	3	1	2	6	3	2	1	6	3	1	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr10:135233650C>T	uc001lnd.2	+	11	1090	c.986C>T	c.(985-987)CCG>CTG	p.P329L	MTG1_uc010qve.1_Missense_Mutation_p.P194L	NM_138384	NP_612393	Q9BT17	MTG1_HUMAN	GTP_binding protein precursor	329						mitochondrion	GTP binding|protein binding			skin(1)	1		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|all cancers(32;1.69e-06)|Epithelial(32;1.94e-06)		GGCCACCCCCCGGCTGAGACT	0.652													17	61					0	0	0	0	T	135233650	T	T	135233650	3	4	77	1	0	0	0	0	1	0	0	0	9979	652	23	1	1028	1	MTG1	10	135233650	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	3593207	135233650	301097	101	15446											
MUC2	4583	broad.mit.edu	37	chr11	1103265	1103265	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatccacaaccagctcatctCgtccgtctccaacatcacct	10	9	4	18	2	4	0	2	0	2	0	8	1	6	0	5	0	3	1	5	0	2	0			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:1103265C>T	uc001lsx.1	+	49	15128	c.15101C>T	c.(15100-15102)TCG>TTG	p.S5034L		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	5034						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CAGCTCATCTCGTCCGTCTCC	0.592													4	69					0	0	0	0	T	1103265	T	T	1103265	3	4	77	1	0	0	0	0	1	0	0	0	10028	893	31	1	8189	1	MUC2	11	1103265	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08		1103265	133903251	102	15447											
OR52A5	390054	broad.mit.edu	37	chr11	5153873	5153873	+	5'Flank	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccattgaatgtcggcatGatttgttcatcagaatcaag	12	12	10	7	1	3	3	3	2	0	1	4	4	3	3	1	1	1	2	1	1	3	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:5153873G>T	uc010qyx.1	-							NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATGTCGGCATGATTTGTTCAT	0.363													6	28					8.12818e-05	8.56433e-05	1	0	T	5153873	T	T	5153873	1	4	77	0	1	0	0	0	0	0	0	0	11164	1305	45	2		2	OR52A5	11	5153873	5'Flank	SNP	G	TCGA-CN-6020-01A-11D-1683-08	4050608	5153873	129852643	103	15448											
TAF10	6881	broad.mit.edu	37	chr11	6632981	6632981	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgtctccgttggccgcgcTcggcagtacgtaaaccccgt	6	8	11	16	7	1	0	0	0	1	0	3	0	1	0	4	2	2	5	4	2	3	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:6632981T>C	uc001mej.1	-	2	326	c.301A>G	c.(301-303)AGC>GGC	p.S101G		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	101					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TTGGCCGCGCTCGGCAGTACG	0.637													3	15					0	0	0	0	C	6632981	C	C	6632981	3	2	77	1	0	0	0	0	1	0	0	0	15580	1551	54	5	371	5	TAF10	11	6632981	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	1479108	6632981	128373535	104	15449											
OR10A3	26496	broad.mit.edu	37	chr11	7960482	7960482	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctgtgaaggcatagatttCaaataagaaggtgtctgcac	13	10	11	7	0	2	3	1	1	1	2	2	3	2	3	1	2	1	2	1	2	5	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:7960482C>G	uc010rbi.1	-	1	586	c.586G>C	c.(586-588)GAA>CAA	p.E196Q		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCATAGATTTCAAATAAGAAG	0.418													9	75					0	0	0	0	G	7960482	G	G	7960482	3	3	77	1	0	0	0	0	1	0	0	0	10945	835	29	2	361	2	OR10A3	11	7960482	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	1327501	7960482	127046034	105	15450											
HPS5	11234	broad.mit.edu	37	chr11	18318517	18318517	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgataaataccagagtccaaGatgctgaaactttcctaaaa	17	9	6	9	1	0	3	0	1	0	2	2	4	2	3	3	0	3	1	3	0	7	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:18318517G>C	uc001mod.1	-	12	1616	c.1338C>G	c.(1336-1338)ATC>ATG	p.I446M	HPS5_uc001moe.1_Missense_Mutation_p.I332M|HPS5_uc001mof.1_Missense_Mutation_p.I332M	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	446						cytosol				ovary(1)|pancreas(1)|skin(1)	3						CAGAGTCCAAGATGCTGAAAC	0.343									Hermansky-Pudlak_syndrome				8	57					0	0	0	0	C	18318517	C	C	18318517	3	2	77	1	0	0	0	0	1	0	0	0	7381	932	33	2	2099	2	HPS5	11	18318517	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	10358035	18318517	116687999	106	15451											
CCDC34	91057	broad.mit.edu	37	chr11	27362288	27362288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atagctctttgcagctggacGaggtttatgtttcgcatttt	7	17	10	7	2	1	0	0	0	1	0	2	2	1	1	0	2	3	6	0	2	2	7			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:27362288G>A	uc001mrh.1	-	5	916	c.862C>T	c.(862-864)CGT>TGT	p.R288C		NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	288											0						GCAGCTGGACGAGGTTTATGT	0.348													6	88					0	0	0	0	A	27362288	A	A	27362288	3	1	77	1	0	0	0	0	1	0	0	0	2820	1058	37	1	267	1	CCDC34	11	27362288	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	9043771	27362288	107644228	107	15452											
NUP160	23279	broad.mit.edu	37	chr11	47823375	47823375	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgatgtaccttgtcataataCtgcagcctgggggtagacac	10	11	11	9	0	1	2	1	1	0	1	1	2	1	2	2	2	4	3	2	2	4	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:47823375C>A	uc001ngm.2	-	23	2968	c.2883G>T	c.(2881-2883)CAG>CAT	p.Q961H	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	961					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						TGTCATAATACTGCAGCCTGG	0.423													7	43					0.00198382	0.00203083	1	0	A	47823375	A	A	47823375	3	1	77	1	0	0	0	0	1	0	0	0	10811	564	20	4	1483	4	NUP160	11	47823375	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	20461087	47823375	87183141	108	15453											
OR4S2	219431	broad.mit.edu	37	chr11	55418983	55419001	+	Frame_Shift_Del	DEL	GGTACCATTGCTCTGGGGA	-	-																															ttgttgtgacagccaacagtGgtaccattgctctggggagt																								rs139625934	byFrequency	TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:55418983_55419001delGGTACCATTGCTCTGGGGA	uc001nhs.1	+	1	604_622	c.604_622delGGTACCATTGCTCTGGGGA	c.(604-624)GGTACCATTGCTCTGGGGAGTfs	p.G202fs		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	202_208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				AGCCAACAGTGGTACCATTGCTCTGGGGAGTTTTGTTAT	0.475													---	---	---								-	55419001	-	-	55418983	7	5	77	1	0	1	0	1	0	0	0	0	11137	1348	47	0	606	0	OR4S2	11	55418983	Frame_Shift_Del	DEL	GGTACCATTGCTCTGGGGA	TCGA-CN-6020-01A-11D-1683-08	7595608	55418983	79587533	109	15454											
FAM111A	63901	broad.mit.edu	37	chr11	58919457	58919457	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgagaatagtagcttatatAtggctctcaacactctccag	12	12	8	9	0	2	1	1	1	2	1	4	2	2	1	1	1	2	3	1	1	7	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:58919457A>T	uc010rkp.1	+	5	543	c.316A>T	c.(316-318)ATG>TTG	p.M106L	FAM111A_uc010rkq.1_Missense_Mutation_p.M106L|FAM111A_uc010rkr.1_Missense_Mutation_p.M106L|FAM111A_uc001nno.2_Missense_Mutation_p.M106L|FAM111A_uc001nnp.2_Missense_Mutation_p.M106L|FAM111A_uc001nnq.2_Missense_Mutation_p.M106L	NM_001142521	NP_001135993	Q96PZ2	F111A_HUMAN	hypothetical protein LOC63901	106					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_epithelial(135;0.139)				TAGCTTATATATGGCTCTCAA	0.403													6	41					0	0	0	0	T	58919457	T	T	58919457	3	4	77	1	0	0	0	0	1	0	0	0	5427	449	16	5	322	5	FAM111A	11	58919457	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	3500474	58919457	76087059	110	15455											
BSCL2	26580	broad.mit.edu	37	chr11	62458142	62458142	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggggctgctgatctggtttCtcctcctcggacagctgacc	5	11	12	13	1	2	2	0	2	2	0	5	3	3	3	3	4	2	4	3	4	0	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:62458142C>T	uc001nuo.1	-	10	1408	c.984G>A	c.(982-984)GAG>GAA	p.E328E	LRRN4CL_uc001nun.2_5'Flank|BSCL2_uc009yoc.1_Missense_Mutation_p.R281K|BSCL2_uc001nup.2_Silent_p.E328E|BSCL2_uc001nuq.1_Silent_p.E328E|BSCL2_uc001nur.3_Silent_p.E392E|BSCL2_uc009yod.2_Silent_p.E392E|BSCL2_uc001nut.3_Silent_p.E394E|HNRNPUL2_uc001nuu.1_RNA	NM_032667	NP_116056	Q96G97	BSCL2_HUMAN	seipin isoform 2	328	Cytoplasmic (Potential).				cell death	integral to endoplasmic reticulum membrane					0						GATCTGGTTTCTCCTCCTCGG	0.612													5	119					0	0	0	0	T	62458142	T	T	62458142	2	4	77	1	0	0	0	0	0	0	0	1	1532	912	32	2		2	BSCL2	11	62458142	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	3538685	62458142	72548374	111	15456											
PITPNM1	9600	broad.mit.edu	37	chr11	67262617	67262617	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaagaggtggggcagcgtGacggtgggaaaggcggtgag	9	5	23	4	3	0	3	0	2	0	1	0	5	0	5	0	8	1	1	0	8	2	0			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:67262617G>A	uc001olx.2	-	16	2751	c.2562C>T	c.(2560-2562)GTC>GTT	p.V854V	PITPNM1_uc001olw.2_Silent_p.V136V|PITPNM1_uc001oly.2_Silent_p.V854V|PITPNM1_uc001olz.2_Silent_p.V853V	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	854	DDHD.				brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						GGGGCAGCGTGACGGTGGGAA	0.667													4	56					0	0	0	0	A	67262617	A	A	67262617	2	1	77	1	0	0	0	0	0	0	0	1	12005	1277	45	2		2	PITPNM1	11	67262617	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	4804475	67262617	67743899	112	15457											
PDE2A	5138	broad.mit.edu	37	chr11	72292985	72292985	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgtcctgcagcatgctcaGgatggcctggagagggcaga	9	7	15	10	0	1	2	1	0	0	2	2	4	2	3	2	4	3	4	2	4	0	0			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:72292985G>A	uc010rrc.1	-	22	2101	c.1858C>T	c.(1858-1860)CTG>TTG	p.L620L	PDE2A_uc001oso.2_Silent_p.L599L|PDE2A_uc010rra.1_Silent_p.L613L|PDE2A_uc001osn.2_Silent_p.L364L|PDE2A_uc010rrb.1_Silent_p.L611L|PDE2A_uc010rrd.1_Silent_p.L505L	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	620					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	AGCATGCTCAGGATGGCCTGG	0.577													8	89					0	0	0	0	A	72292985	A	A	72292985	2	1	77	1	0	0	0	0	0	0	0	1	11690	991	35	4		4	PDE2A	11	72292985	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	5030368	72292985	62713531	113	15458											
DLG2	1740	broad.mit.edu	37	chr11	83585526	83585526	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagttgcggtgctatgttggGaatgactgcaagaaaagaca	13	9	14	5	1	0	3	0	1	0	2	0	5	0	4	0	2	3	4	0	2	5	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:83585526G>A	uc001paj.2	-	11	1490	c.1187C>T	c.(1186-1188)TCC>TTC	p.S396F	DLG2_uc001pai.2_Missense_Mutation_p.S293F|DLG2_uc010rsy.1_Missense_Mutation_p.S363F|DLG2_uc010rsz.1_Missense_Mutation_p.S396F|DLG2_uc010rta.1_Missense_Mutation_p.S396F|DLG2_uc001pak.2_Missense_Mutation_p.S501F|DLG2_uc010rtb.1_Missense_Mutation_p.S363F|DLG2_uc001pal.1_Missense_Mutation_p.S396F|DLG2_uc001pam.1_Missense_Mutation_p.S435F	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	396						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GCTATGTTGGGAATGACTGCA	0.318													9	32					0	0	0	0	A	83585526	A	A	83585526	3	1	77	1	0	0	0	0	1	0	0	0	4577	1174	41	2	1527	2	DLG2	11	83585526	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	11292541	83585526	51420990	114	15459											
FAT3	120114	broad.mit.edu	37	chr11	92577460	92577460	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtggagcagttggtgcatGagatgctgcagaacactgtc	10	10	14	7	0	0	2	0	1	0	2	1	4	0	3	0	2	5	5	0	2	1	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:92577460G>A	uc001pdj.3	+	18	10944	c.10927G>A	c.(10927-10929)GAG>AAG	p.E3643K	FAT3_uc001pdi.3_Missense_Mutation_p.E83K	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3643	Cadherin 33.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTTGGTGCATGAGATGCTGCA	0.562										TCGA Ovarian(4;0.039)			9	102					0	0	0	0	A	92577460	A	A	92577460	3	1	77	1	0	0	0	0	1	0	0	0	5723	1291	45	2	10997	2	FAT3	11	92577460	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	8991934	92577460	42429056	115	15460											
SPATA19	219938	broad.mit.edu	37	chr11	133712445	133712445	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctcacttggcacttggaaGatacgagtgtggctgcaaaa	12	10	11	8	1	1	1	1	0	1	1	2	3	1	2	0	3	2	3	0	3	4	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr11:133712445G>A	uc001qgv.1	-	5	423	c.372C>T	c.(370-372)ATC>ATT	p.I124I		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	124					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		GCACTTGGAAGATACGAGTGT	0.468													5	61					0	0	0	0	A	133712445	A	A	133712445	2	1	77	1	0	0	0	0	0	0	0	1	15070	932	33	2		2	SPATA19	11	133712445	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	41134985	133712445	1294071	116	15461											
WNK1	65125	broad.mit.edu	37	chr12	988982	988982	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctggcattactcagcctCtgctcacgttggcttcatct	6	13	8	14	1	5	0	3	0	2	0	5	0	5	0	1	2	4	5	1	2	1	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:988982C>T	uc001qio.3	+	11	3124	c.2617C>T	c.(2617-2619)CTG>TTG	p.L873L	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	873					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TACTCAGCCTCTGCTCACGTT	0.532													18	76					0	0	0	0	T	988982	T	T	988982	2	4	77	1	0	0	0	0	0	0	0	1	17445	912	32	2		2	WNK1	12	988982	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08		988982	132862913	117	15462											
CD163	9332	broad.mit.edu	37	chr12	7653982	7653982	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacacaccgttccccactcCtcctggactttcacttccac	7	12	3	19	1	1	0	1	0	0	0	5	1	5	1	6	1	1	1	6	1	1	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:7653982C>T	uc001qsz.3	-	3	338	c.210G>A	c.(208-210)GAG>GAA	p.E70E	CD163_uc001qta.3_Silent_p.E70E|CD163_uc009zfw.2_Silent_p.E70E	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	70	SRCR 1.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TTCCCCACTCCTCCTGGACTT	0.507													10	60					0	0	0	0	T	7653982	T	T	7653982	2	4	77	1	0	0	0	0	0	0	0	1	2982	680	24	4		4	CD163	12	7653982	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	6665000	7653982	126197913	118	15463											
A2ML1	144568	broad.mit.edu	37	chr12	9001323	9001323	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctcttgtcccaggtctatgGgatgtttccattctggtatg	5	16	10	10	0	3	0	0	0	3	0	5	1	5	1	3	3	0	2	3	3	2	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:9001323G>A	uc001quz.3	+	16	1939	c.1841G>A	c.(1840-1842)GGG>GAG	p.G614E	A2ML1_uc001qva.1_Missense_Mutation_p.G194E|A2ML1_uc010sgm.1_Missense_Mutation_p.G114E	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	458						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						CAGGTCTATGGGATGTTTCCA	0.473													19	112					0	0	0	0	A	9001323	A	A	9001323	3	1	77	1	0	0	0	0	1	0	0	0	5	1232	43	4	1903	4	A2ML1	12	9001323	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	1347341	9001323	124850572	119	15464											
GRIN2B	2904	broad.mit.edu	37	chr12	13716470	13716470	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggatgcacgcctgcctgccCgagttctgacccgtcaccgt	5	8	11	17	5	2	1	1	1	1	0	2	3	2	2	5	1	3	2	5	1	0	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:13716470C>A	uc001rbt.2	-	13	3881	c.3702G>T	c.(3700-3702)TCG>TCT	p.S1234S		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1234	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCTGCCTGCCCGAGTTCTGAC	0.617													5	55					3.59834e-05	3.82877e-05	1	0	A	13716470	A	A	13716470	2	1	77	1	0	0	0	0	0	0	0	1	6819	639	23	3		3	GRIN2B	12	13716470	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	4715147	13716470	120135425	120	15465											
MGP	4256	broad.mit.edu	37	chr12	15035947	15035947	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catctctgctgaggggatatGaaggtatttgcatttctcct	8	15	10	8	0	2	2	0	2	2	0	4	3	2	3	1	3	2	3	1	3	3	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:15035947G>A	uc001rcn.1	-	3	232	c.129C>T	c.(127-129)TTC>TTT	p.F43F		NM_000900	NP_000891	P08493	MGP_HUMAN	matrix Gla protein precursor	43					cartilage condensation|cell differentiation|ossification|regulation of bone mineralization	proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent|structural constituent of bone			ovary(1)	1						GAGGGGATATGAAGGTATTTG	0.383													7	60					0	0	0	0	A	15035947	A	A	15035947	2	1	77	1	0	0	0	0	0	0	0	1	9611	1281	45	2		2	MGP	12	15035947	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	1319477	15035947	118815948	121	15466											
LRRK2	120892	broad.mit.edu	37	chr12	40643742	40643742	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgctcagctgtttggcccTcctcagtaagtaacttcact	8	12	8	13	1	3	0	3	0	0	0	4	0	4	0	2	1	3	5	2	1	2	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:40643742T>A	uc001rmg.3	+	8	1074	c.953T>A	c.(952-954)CTC>CAC	p.L318H	LRRK2_uc001rmh.1_5'Flank	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	318					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TGTTTGGCCCTCCTCAGTAAG	0.423													3	28					0	0	0	0	A	40643742	A	A	40643742	3	1	77	1	0	0	0	0	1	0	0	0	9083	1551	54	5	983	5	LRRK2	12	40643742	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	25607795	40643742	93208153	122	15467											
PDZRN4	29951	broad.mit.edu	37	chr12	41967396	41967396	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcgagatgaaaatggggCgctactggagcaaagaggag	14	5	17	5	2	0	4	0	2	0	2	0	7	0	6	0	4	3	2	0	4	4	1	rs144265671		TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:41967396C>T	uc010skn.1	+	10	2286	c.2218C>T	c.(2218-2220)CGC>TGC	p.R740C	PDZRN4_uc001rmq.3_Missense_Mutation_p.R681C|PDZRN4_uc009zjz.2_Missense_Mutation_p.R679C|PDZRN4_uc001rmr.2_Missense_Mutation_p.R566C	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	939							ubiquitin-protein ligase activity|zinc ion binding	p.R681C(1)		lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAAATGGGGCGCTACTGGAG	0.542													9	31					0	0	0	0	T	41967396	T	T	41967396	3	4	77	1	0	0	0	0	1	0	0	0	11764	768	27	1	2926	1	PDZRN4	12	41967396	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	1323654	41967396	91884499	123	15468											
CACNB3	784	broad.mit.edu	37	chr12	49221458	49221458	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaggccagcgagagctccCgccaagcctggacaggatct	10	5	13	13	2	1	2	0	1	1	1	2	5	2	4	4	3	3	1	4	3	1	0	rs146819236		TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:49221458C>T	uc001rsl.1	+	13	1432	c.1231C>T	c.(1231-1233)CGC>TGC	p.R411C	CACNB3_uc010sly.1_Missense_Mutation_p.R398C|CACNB3_uc010slz.1_Missense_Mutation_p.R410C|CACNB3_uc001rsk.1_Missense_Mutation_p.R258C	NM_000725	NP_000716	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3	411					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0					Verapamil(DB00661)	CGAGAGCTCCCGCCAAGCCTG	0.647													7	41					0	0	0	0	T	49221458	T	T	49221458	3	4	77	1	0	0	0	0	1	0	0	0	2566	652	23	1	1281	1	CACNB3	12	49221458	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	7254062	49221458	84630437	124	15469											
TROAP	10024	broad.mit.edu	37	chr12	49721061	49721061	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggaggtgtggcctctcttgGtctggcccagcgagtaccat	6	10	14	11	1	2	0	0	0	2	0	3	2	2	1	3	5	2	1	3	5	1	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:49721061G>A	uc001rtx.3	+	8	1006	c.839G>A	c.(838-840)GGT>GAT	p.G280D	TROAP_uc009zlh.2_Missense_Mutation_p.G280D|TROAP_uc001rty.2_5'UTR	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	280					cell adhesion	cytoplasm				ovary(1)	1						GCCTCTCTTGGTCTGGCCCAG	0.512													12	61					0	0	0	0	A	49721061	A	A	49721061	3	1	77	1	0	0	0	0	1	0	0	0	16642	1261	44	4	967	4	TROAP	12	49721061	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	499603	49721061	84130834	125	15470											
KRT73	319101	broad.mit.edu	37	chr12	53012018	53012018	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atacccccgggcgggcacaaCgacggacacacggaccccaa	12	1	11	17	5	0	0	0	0	0	0	0	3	0	2	4	4	2	1	4	4	3	1	rs142655706	byFrequency	TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:53012018C>T	uc001sas.2	-	1	326	c.291G>A	c.(289-291)TCG>TCA	p.S97S		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	97	Head.|Gly-rich.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCGGGCACAACGACGGACACA	0.637													12	111					0	0	0	0	T	53012018	T	T	53012018	2	4	77	1	0	0	0	0	0	0	0	1	8525	523	19	1		1	KRT73	12	53012018	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	3290957	53012018	80839877	126	15471											
PTPRB	5787	broad.mit.edu	37	chr12	70929923	70929923	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgagtgacaatgtattctCttctgaagttgttgccctgc	7	15	9	10	0	2	3	0	3	2	0	3	3	2	3	2	0	2	3	2	0	3	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:70929923C>A	uc001swb.3	-	27	5339	c.5309G>T	c.(5308-5310)AGA>ATA	p.R1770I	uc001svz.2_Intron|PTPRB_uc010sto.1_Missense_Mutation_p.R1680I|PTPRB_uc010stp.1_Missense_Mutation_p.R1680I|PTPRB_uc001swc.3_Missense_Mutation_p.R1988I|PTPRB_uc001swa.3_Missense_Mutation_p.R1900I	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1770	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AATGTATTCTCTTCTGAAGTT	0.428													3	23					2.56e-06	2.79273e-06	1	0	A	70929923	A	A	70929923	3	1	77	1	0	0	0	0	1	0	0	0	12861	913	32	2	708	2	PTPRB	12	70929923	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	17917905	70929923	62921972	127	15472											
TMEM132B	114795	broad.mit.edu	37	chr12	126128737	126128737	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagttcgaggtcactgtctGggcacccaggctccccctgc	5	8	11	17	1	2	0	1	0	1	0	4	1	3	0	4	3	1	3	4	3	0	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr12:126128737G>A	uc001uhe.1	+	6	1546	c.1538G>A	c.(1537-1539)TGG>TAG	p.W513*	TMEM132B_uc001uhf.1_Nonsense_Mutation_p.W25*	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	513	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GTCACTGTCTGGGCACCCAGG	0.537													5	44					0	0	0	0	A	126128737	A	A	126128737	4	1	77	1	0	0	0	0	0	1	0	0	16112	1357	47	4	1560	4	TMEM132B	12	126128737	Nonsense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	55198814	126128737	7723158	128	15473											
KIAA0564	23078	broad.mit.edu	37	chr13	42295521	42295521	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctacctgtaaatgtttgacTatgttgacaacttctctggt	9	16	7	9	0	1	2	0	2	1	0	2	2	1	2	2	1	2	3	2	1	5	6			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr13:42295521T>A	uc001uyj.2	-	25	3019	c.2949A>T	c.(2947-2949)ATA>ATT	p.I983I	KIAA0564_uc001uyk.2_Silent_p.I983I	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	983						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		AATGTTTGACTATGTTGACAA	0.408													8	125					0	0	0	0	A	42295521	A	A	42295521	2	1	77	1	0	0	0	0	0	0	0	1	8224	1512	53	5		5	KIAA0564	13	42295521	Silent	SNP	T	TCGA-CN-6020-01A-11D-1683-08		42295521	72874357	129	15474											
PCDH20	64881	broad.mit.edu	37	chr13	61985826	61985826	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcttccaaagtaatgttGccagttttagggtcaatcct	9	14	8	10	0	2	0	1	0	1	0	4	0	4	0	4	1	1	3	4	1	4	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr13:61985826G>A	uc001vid.3	-	2	2770	c.2406C>T	c.(2404-2406)GGC>GGT	p.G802G	PCDH20_uc010thj.1_Silent_p.G802G	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	775	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		AAGTAATGTTGCCAGTTTTAG	0.488													13	58					0	0	0	0	A	61985826	A	A	61985826	2	1	77	1	0	0	0	0	0	0	0	1	11569	1306	46	4		4	PCDH20	13	61985826	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	19690305	61985826	53184052	130	15475											
OR11H6	122748	broad.mit.edu	37	chr14	20692714	20692714	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtatgtgagcccaacatcAgggaacccagcaggaatgca	14	6	11	10	0	1	1	1	1	0	0	1	3	1	3	2	2	5	3	2	2	4	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr14:20692714A>T	uc010tlc.1	+	1	846	c.846A>T	c.(844-846)TCA>TCT	p.S282S		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	282	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		GCCCAACATCAGGGAACCCAG	0.448													5	71					0	0	0	0	T	20692714	T	T	20692714	2	4	77	1	0	0	0	0	0	0	0	1	10983	175	7	5		5	OR11H6	14	20692714	Silent	SNP	A	TCGA-CN-6020-01A-11D-1683-08		20692714	86656826	131	15476											
ASB2	51676	broad.mit.edu	37	chr14	94417436	94417436	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taggcgttcttggattccacCttggctcctccgctcaccag	5	12	9	15	2	2	0	1	0	1	0	5	1	5	1	5	3	0	3	5	3	1	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr14:94417436C>T	uc001ycc.1	-	4	1134	c.645G>A	c.(643-645)AAG>AAA	p.K215K	ASB2_uc001ycd.2_Silent_p.K263K|ASB2_uc001yce.1_Silent_p.K161K	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	215	ANK 5.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		TGGATTCCACCTTGGCTCCTC	0.607													8	98					0	0	0	0	T	94417436	T	T	94417436	2	4	77	1	0	0	0	0	0	0	0	1	1025	680	24	4		4	ASB2	14	94417436	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	73724722	94417436	12932104	132	15477											
HERC2	8924	broad.mit.edu	37	chr15	28386662	28386662	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgcaagggcttcacagggAgtgggaactttgacttttgc	8	12	14	7	0	1	1	1	1	0	0	1	3	1	3	0	3	3	3	0	3	2	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr15:28386662A>C	uc001zbj.2	-	78	12037	c.11931T>G	c.(11929-11931)ACT>ACG	p.T3977T		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3977	RCC1 13.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTTCACAGGGAGTGGGAACTT	0.537													4	61					0	0	0	0	C	28386662	C	C	28386662	2	2	77	1	0	0	0	0	0	0	0	1	7097	291	11	5		5	HERC2	15	28386662	Silent	SNP	A	TCGA-CN-6020-01A-11D-1683-08		28386662	74144730	133	15478											
TRPM1	4308	broad.mit.edu	37	chr15	31323321	31323321	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactccgaaactcatgagcaCgaccagcatgatgaccacaa	15	6	7	13	2	1	3	1	3	0	0	2	5	2	3	3	0	4	2	3	0	3	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr15:31323321C>T	uc001zfm.2	-	22	3054	c.2926G>A	c.(2926-2928)GTG>ATG	p.V976M	TRPM1_uc010azy.2_Missense_Mutation_p.V883M|TRPM1_uc001zfl.2_Intron	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	976	Helical; (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CTCATGAGCACGACCAGCATG	0.507													13	62					0	0	0	0	T	31323321	T	T	31323321	3	4	77	1	0	0	0	0	1	0	0	0	16652	536	19	1	1909	1	TRPM1	15	31323321	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	2936659	31323321	71208071	134	15479											
THBS1	7057	broad.mit.edu	37	chr15	39874946	39874946	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaggggggcgtcaatgacaAtttccaggtgaggcttcttc	10	10	13	8	1	2	2	1	2	1	0	4	2	3	2	1	5	0	1	1	5	3	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr15:39874946A>G	uc001zkh.2	+	3	799	c.620A>G	c.(619-621)AAT>AGT	p.N207S		NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	207	TSP N-terminal.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GTCAATGACAATTTCCAGGTG	0.552													3	30					0	0	0	0	G	39874946	G	G	39874946	3	3	77	1	0	0	0	0	1	0	0	0	15919	101	4	5	626	5	THBS1	15	39874946	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	8551625	39874946	62656446	135	15480											
C15orf63	25764	broad.mit.edu	37	chr15	44092849	44092849	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagggggatgtggagctggAgttggagactgagaccagtg	9	7	20	5	1	0	2	0	1	0	2	0	8	0	5	1	5	1	2	1	5	0	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr15:44092849A>T	uc001ztf.2	+	1	229	c.53A>T	c.(52-54)GAG>GTG	p.E18V	ELL3_uc001zsx.1_5'Flank|C15orf63_uc001ztb.2_Missense_Mutation_p.E64V|SERINC4_uc001ztc.1_5'Flank|SERINC4_uc001ztd.1_5'Flank|SERINC4_uc010bds.1_5'Flank|SERINC4_uc001zte.1_5'Flank|C15orf63_uc001ztg.1_Missense_Mutation_p.E10V	NM_016400	NP_057484	Q9NX55	HYPK_HUMAN	chromosome 15 open reading frame 63	18											0						GTGGAGCTGGAGTTGGAGACT	0.632													9	15					0	0	0	0	T	44092849	T	T	44092849	3	4	77	1	0	0	0	0	1	0	0	0	1815	304	11	5	55	5	C15orf63	15	44092849	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	4217903	44092849	58438543	136	15481											
CGNL1	84952	broad.mit.edu	37	chr15	57734631	57734631	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtctttgagaaaatccaGaccttaaagtctcgagcagc	12	11	9	9	1	2	2	0	1	2	2	4	4	3	2	2	1	2	1	2	1	4	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr15:57734631G>C	uc002aeg.2	+	4	1834	c.1758G>C	c.(1756-1758)CAG>CAC	p.Q586H	CGNL1_uc010bfw.2_Missense_Mutation_p.Q586H	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	586						myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGAAAATCCAGACCTTAAAGT	0.408													14	52					0	0	0	0	C	57734631	C	C	57734631	3	2	77	1	0	0	0	0	1	0	0	0	3319	933	33	2	1768	2	CGNL1	15	57734631	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	13641782	57734631	44796761	137	15482											
HEXA	3073	broad.mit.edu	37	chr15	72668095	72668095	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggggccaagacccggaaccGaaaagcaggtcacgatagcg	13	2	14	12	5	1	1	1	0	0	1	1	4	1	2	3	4	3	1	3	4	5	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr15:72668095G>A	uc002aun.3	-	1	426	c.219C>T	c.(217-219)TTC>TTT	p.F73F	CELF6_uc002auk.3_RNA|HEXA_uc010ukn.1_Silent_p.F73F|HEXA_uc002auo.3_5'UTR|HEXA_uc010bix.2_Silent_p.F73F|HEXA_uc010biy.2_5'UTR|HEXA_uc010uko.1_5'UTR|HEXA_uc010biz.1_RNA|C15orf34_uc010ukp.1_5'Flank	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	73					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			ovary(3)|upper_aerodigestive_tract(1)	4						ACCCGGAACCGAAAAGCAGGT	0.627													24	161					0	0	0	0	A	72668095	A	A	72668095	2	1	77	1	0	0	0	0	0	0	0	1	7112	1049	37	1		1	HEXA	15	72668095	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	14933464	72668095	29863297	138	15483											
CLK3	1198	broad.mit.edu	37	chr15	74919948	74919948	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttggcagtgccacatttgaCcatgagcaccacaccaccat	11	9	7	14	0	0	2	0	2	0	0	0	2	0	2	5	1	2	2	5	1	0	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr15:74919948C>A	uc010uln.1	+	9	1886	c.1425C>A	c.(1423-1425)GAC>GAA	p.D475E	CLK3_uc002ayg.3_Missense_Mutation_p.D327E|CLK3_uc002ayh.3_Missense_Mutation_p.D106E|CLK3_uc002ayj.3_Missense_Mutation_p.D304E|CLK3_uc002ayk.3_Missense_Mutation_p.D254E|CLK3_uc002ayl.3_Missense_Mutation_p.D160E	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	475	Protein kinase.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						CCACATTTGACCATGAGCACC	0.562													33	110					9.17885e-22	1.06593e-21	1	0	A	74919948	A	A	74919948	3	1	77	1	0	0	0	0	1	0	0	0	3553	506	18	4	1459	4	CLK3	15	74919948	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	2251853	74919948	27611444	139	15484											
BTBD1	53339	broad.mit.edu	37	chr15	83718833	83718833	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagcgaacttacctatatcaAtatcagtaaacccttctgca	14	12	4	11	1	3	0	2	0	1	0	3	1	3	0	2	0	5	2	2	0	9	7			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr15:83718833A>T	uc002bjn.2	-	3	859	c.656T>A	c.(655-657)ATT>AAT	p.I219N	BTBD1_uc002bjo.2_Missense_Mutation_p.I219N	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	219						cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		ACCTATATCAATATCAGTAAA	0.358													6	45					0	0	0	0	T	83718833	T	T	83718833	3	4	77	1	0	0	0	0	1	0	0	0	1542	101	4	5	816	5	BTBD1	15	83718833	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	8798885	83718833	18812559	140	15485											
C15orf42	90381	broad.mit.edu	37	chr15	90127621	90127621	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tttttctaaaaggctcagtgGcccagtggtctctcccaacg	8	12	9	12	1	3	0	1	0	2	0	5	0	4	0	2	3	1	1	2	3	3	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr15:90127621G>T	uc002boe.2	+	3	1039	c.1039G>T	c.(1039-1041)GCC>TCC	p.A347S		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	347					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			AGGCTCAGTGGCCCAGTGGTC	0.488													16	56					1.15088e-07	1.29474e-07	1	0	T	90127621	T	T	90127621	3	4	77	1	0	0	0	0	1	0	0	0	1802	1203	42	4	1049	4	C15orf42	15	90127621	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	6408788	90127621	12403771	141	15486											
PKD1	5310	broad.mit.edu	37	chr16	2166554	2166554	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgggctcgtgcggggctgaGaggccgtcctgctgtgccag	4	7	18	12	4	0	1	0	1	0	1	2	2	1	1	3	4	3	3	3	4	0	0			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr16:2166554G>A	uc002cos.1	-	8	1907	c.1698C>T	c.(1696-1698)CTC>CTT	p.L566L	PKD1_uc002cot.1_Silent_p.L566L	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	566	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GCGGGGCTGAGAGGCCGTCCT	0.711													2	2					0	0	0	0	A	2166554	A	A	2166554	2	1	77	1	0	0	0	0	0	0	0	1	12018	929	33	2		2	PKD1	16	2166554	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08		2166554	88188199	142	15487											
SMG1	23049	broad.mit.edu	37	chr16	18840818	18840819	+	Frame_Shift_Del	DEL	TT	-	-																															cagagatcatcaacagaaacTttgctttcggcaccaaagtc																										TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr16:18840818_18840819delTT	uc002dfm.2	-	54	9755_9756	c.9392_9393delAA	c.(9391-9393)AAAfs	p.K3131fs	SMG1_uc010bwb.2_Frame_Shift_Del_p.K2991fs|SMG1_uc010bwa.2_Frame_Shift_Del_p.K1862fs	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3131					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CAACAGAAACTTTGCTTTCGGC	0.465													---	---	---								-	18840819	-	-	18840818	7	5	77	1	0	1	0	1	0	0	0	0	14859	1606	56	0	1632	0	SMG1	16	18840818	Frame_Shift_Del	DEL	TT	TCGA-CN-6020-01A-11D-1683-08	16674264	18840818	71513935	143	15488											
MMP2	4313	broad.mit.edu	37	chr16	55530841	55530841	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccttgcctcctgccaggttCatttggcggactgtgacgcc	4	11	11	15	2	1	1	1	1	0	0	2	2	2	2	5	3	2	1	5	3	0	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr16:55530841C>T	uc002ehz.3	+	10	1787	c.1476C>T	c.(1474-1476)TTC>TTT	p.F492F	MMP2_uc010vhd.1_Silent_p.F416F|MMP2_uc010ccc.2_Silent_p.F442F|MMP2_uc002eia.3_5'UTR	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	492	Required for inhibitor TIMP2 binding.|Hemopexin-like 1.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CTGCCAGGTTCATTTGGCGGA	0.592													6	65					0	0	0	0	T	55530841	T	T	55530841	2	4	77	1	0	0	0	0	0	0	0	1	9711	825	29	2		2	MMP2	16	55530841	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	36690023	55530841	34823912	144	15489											
CDH5	1003	broad.mit.edu	37	chr16	66432402	66432402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agacaaggacataacaccacGaaacgtgaagttcaaattca	19	6	7	9	2	2	2	2	1	0	1	2	4	2	3	1	1	2	1	1	1	5	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr16:66432402G>A	uc002eom.3	+	10	1685	c.1529G>A	c.(1528-1530)CGA>CAA	p.R510Q		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	510	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		ATAACACCACGAAACGTGAAG	0.443													3	43					0	0	0	0	A	66432402	A	A	66432402	3	1	77	1	0	0	0	0	1	0	0	0	3128	1058	37	1	1563	1	CDH5	16	66432402	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	10901561	66432402	23922351	145	15490											
GLG1	2734	broad.mit.edu	37	chr16	74537551	74537551	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtcatcttggtaatgtactGgtgacactgatactcagtga	10	13	10	8	1	3	3	2	3	1	0	3	3	3	3	0	2	2	2	0	2	3	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr16:74537551G>A	uc002fcy.3	-	4	702	c.652C>T	c.(652-654)CAG>TAG	p.Q218*	GLG1_uc002fcx.2_Nonsense_Mutation_p.Q218*|GLG1_uc002fcw.3_Nonsense_Mutation_p.Q207*|GLG1_uc002fcz.3_5'UTR	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	218	Extracellular (Potential).|Cys-rich GLG1 3.					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						GTAATGTACTGGTGACACTGA	0.423													21	104					0	0	0	0	A	74537551	A	A	74537551	4	1	77	1	0	0	0	0	0	1	0	0	6473	1357	47	4	3059	4	GLG1	16	74537551	Nonsense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	8105149	74537551	15817202	146	15491											
TP53	7157	broad.mit.edu	37	chr17	7578177	7578177	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accccagttgcaaaccagacCtcaggcggctcatagggcac	11	5	10	15	1	2	1	2	0	0	1	2	1	2	1	4	3	2	4	4	3	2	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr17:7578177C>A	uc002gim.2	-	6	866	c.672G>T	c.(670-672)GAG>GAT	p.E224D	TP53_uc002gig.1_Missense_Mutation_p.E224D|TP53_uc002gih.2_Missense_Mutation_p.E224D|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E92D|TP53_uc010cng.1_Missense_Mutation_p.E92D|TP53_uc002gii.1_Missense_Mutation_p.E92D|TP53_uc010cnh.1_Missense_Mutation_p.E224D|TP53_uc010cni.1_Missense_Mutation_p.E224D|TP53_uc002gij.2_Missense_Mutation_p.E224D|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.E131D|TP53_uc002gio.2_Missense_Mutation_p.E92D|TP53_uc010vug.1_Missense_Mutation_p.E185D	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	224	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E224D(11)|p.0?(7)|p.E224E(6)|p.E224K(5)|p.E224*(4)|p.?(3)|p.E224G(2)|p.E224fs*4(1)|p.E224fs*5(1)|p.V218_E224delVPYEPPE(1)|p.E224fs*23(1)|p.V225fs*24(1)|p.E224fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAACCAGACCTCAGGCGGCT	0.522		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	6					5.18039e-06	5.62294e-06	1	0	A	7578177	A	A	7578177	3	1	77	1	0	0	0	0	1	0	0	0	16448	695	24	4	622	4	TP53	17	7578177	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08		7578177	73617033	147	15492											
MYH1	4619	broad.mit.edu	37	chr17	10418213	10418213	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatagactgattctcccgatCtagaagaaaaacagtggaaa	17	8	9	7	1	2	4	0	1	2	3	3	7	2	5	1	1	1	0	1	1	6	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr17:10418213C>G	uc002gmo.2	-	6	600	c.506_splice	c.e6-1	p.D169_splice	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult							muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TTCTCCCGATCTAGAAGAAAA	0.328													3	80					0	0	0	0	G	10418213	G	G	10418213	5	3	77	1	0	0	0	0	0	0	1	0	10082	927	32	2	5454	2	MYH1	17	10418213	Splice_Site	SNP	C	TCGA-CN-6020-01A-11D-1683-08	2840036	10418213	70776997	148	15493											
GAS2L2	246176	broad.mit.edu	37	chr17	34073141	34073141	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggctgggccaaaggaacgagGcaggggagatggtcctcttg	9	6	18	8	1	1	1	0	0	1	1	2	4	2	2	2	7	1	2	2	7	2	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr17:34073141G>A	uc002hjv.1	-	6	1403	c.1375C>T	c.(1375-1377)CCT>TCT	p.P459S		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	459					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AAGGAACGAGGCAGGGGAGAT	0.632													21	99					0	0	0	0	A	34073141	A	A	34073141	3	1	77	1	0	0	0	0	1	0	0	0	6282	1203	42	4	1271	4	GAS2L2	17	34073141	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	23654928	34073141	47122069	149	15494											
OR4D1	26689	broad.mit.edu	37	chr17	56233093	56233093	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgcctgcactgatacctcCctcctggagttcctcatgat	6	13	7	15	0	1	2	1	2	0	0	4	3	4	3	5	1	3	2	5	1	1	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr17:56233093C>T	uc010wno.1	+	1	579	c.579C>T	c.(577-579)TCC>TCT	p.S193S	MSX2P1_uc002ivn.2_5'Flank	NM_012374	NP_036506	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTGATACCTCCCTCCTGGAGT	0.493													36	48					0	0	0	0	T	56233093	T	T	56233093	2	4	77	1	0	0	0	0	0	0	0	1	11107	610	22	4		4	OR4D1	17	56233093	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	22159952	56233093	24962117	150	15495											
MIF4GD	57409	broad.mit.edu	37	chr17	73264171	73264171	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaacccccaacctgaatgAtggcgtagcacatgcgtcct	10	7	8	16	2	0	2	0	2	0	0	1	2	1	2	5	1	4	2	5	1	4	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr17:73264171A>T	uc002jnr.2	-	3	314	c.185T>A	c.(184-186)ATC>AAC	p.I62N	MIF4GD_uc002jno.2_Missense_Mutation_p.I103N|MIF4GD_uc002jnp.2_Missense_Mutation_p.I96N|MIF4GD_uc002jnq.2_Missense_Mutation_p.I103N			A9UHW6	MI4GD_HUMAN	RecName: Full=MIF4G domain-containing protein; AltName: Full=SLBP-interacting protein 1;          Short=hSLIP1;	62	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			ovary(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			AACCTGAATGATGGCGTAGCA	0.562													6	42					0	0	0	0	T	73264171	T	T	73264171	3	4	77	1	0	0	0	0	1	0	0	0	9637	333	12	5	499	5	MIF4GD	17	73264171	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	17031078	73264171	7931039	151	15496											
DNAH17	8632	broad.mit.edu	37	chr17	76420210	76420210	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gccgcgcttcagcgatgactCcagtctgggtgtcccagcga	6	8	13	14	4	2	1	1	1	1	0	4	3	4	1	3	1	2	1	3	1	0	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr17:76420210C>G	uc010dhp.1	-	26	4388	c.4166G>C	c.(4165-4167)GGA>GCA	p.G1389A	PGS1_uc002jvm.2_3'UTR|PGS1_uc010wtt.1_RNA|PGS1_uc010dho.2_RNA|PGS1_uc002jvn.2_3'UTR|PGS1_uc002jvo.2_RNA|DNAH17_uc002jvq.2_Missense_Mutation_p.G674A|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGCGATGACTCCAGTCTGGGT	0.607													7	34					0	0	0	0	G	76420210	G	G	76420210	3	3	77	1	0	0	0	0	1	0	0	0	4623	855	30	2	226	2	DNAH17	17	76420210	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	3156039	76420210	4775000	152	15497											
FAM38B	63895	broad.mit.edu	37	chr18	10672764	10672764	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agttccagggcctgagagttCggattgtatattctgtttcc	7	15	11	8	1	1	1	0	1	1	1	4	3	3	2	3	2	0	4	3	2	2	7	rs138454862	byFrequency	TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr18:10672764C>T	uc002kor.3	-	13	1940	c.1800G>A	c.(1798-1800)CCG>CCA	p.P600P	FAM38B_uc002koq.2_Silent_p.P435P	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2643						integral to membrane	ion channel activity			ovary(1)	1						CCTGAGAGTTCGGATTGTATA	0.438													11	90					0	0	0	0	T	10672764	T	T	10672764	2	4	77	1	0	0	0	0	0	0	0	1	5587	871	31	1		1	FAM38B	18	10672764	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08		10672764	67404484	153	15498											
CABLES1	91768	broad.mit.edu	37	chr18	20837210	20837210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaactggaagagaagttccGgctgaacaggcgagaactga	15	5	14	7	2	0	4	0	2	0	2	1	8	1	5	1	3	3	2	1	3	5	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr18:20837210G>A	uc002kuc.2	+	10	1781	c.1781G>A	c.(1780-1782)CGG>CAG	p.R594Q	C18orf45_uc010xaq.1_Intron|CABLES1_uc002kub.2_Missense_Mutation_p.R97Q|CABLES1_uc002kud.2_Missense_Mutation_p.R329Q	NM_001100619	NP_001094089	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1 isoform 2	594					blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)	1	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GAGAAGTTCCGGCTGAACAGG	0.448													8	75					0	0	0	0	A	20837210	A	A	20837210	3	1	77	1	0	0	0	0	1	0	0	0	2541	1116	39	1	1873	1	CABLES1	18	20837210	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	10164446	20837210	57240038	154	15499											
ATP9B	374868	broad.mit.edu	37	chr18	76873289	76873289	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaatctctattttctagtaAtatcctgctcacagtttgta	10	18	5	8	0	3	1	1	1	2	0	5	1	4	1	1	0	1	4	1	0	6	8			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr18:76873289A>T	uc002lmx.2	+	4	507	c.493A>T	c.(493-495)ATA>TTA	p.I165L	ATP9B_uc002lmv.1_RNA|ATP9B_uc002lmw.1_Missense_Mutation_p.I165L|ATP9B_uc002lmy.1_RNA|ATP9B_uc002lmz.1_5'UTR|ATP9B_uc002lmu.2_Missense_Mutation_p.I165L	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	165	Helical; (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		TTTTCTAGTAATATCCTGCTC	0.294													6	34					0	0	0	0	T	76873289	T	T	76873289	3	4	77	1	0	0	0	0	1	0	0	0	1201	101	4	5	507	5	ATP9B	18	76873289	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	56036079	76873289	1203959	155	15500											
ZNRF4	148066	broad.mit.edu	37	chr19	5456159	5456159	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcgtgagcgaggccgcctcGcaggacctgcgggtcatcct	5	8	14	14	5	1	1	1	1	0	0	4	3	2	2	4	3	2	1	4	3	0	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:5456159G>A	uc002mca.3	+	1	734	c.657G>A	c.(655-657)TCG>TCA	p.S219S		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	219	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		AGGCCGCCTCGCAGGACCTGC	0.667													11	77					0	0	0	0	A	5456159	A	A	5456159	2	1	77	1	0	0	0	0	0	0	0	1	18281	1074	38	1		1	ZNRF4	19	5456159	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08		5456159	53672824	156	15501											
PPAN-P2RY11	692312	broad.mit.edu	37	chr19	10225067	10225067	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtggccctctacgccagcTcctatgtgccctaccacatc	6	10	8	17	1	1	0	0	0	1	0	3	0	2	0	5	1	4	1	5	1	3	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:10225067T>A	uc002mna.2	+	13	2038	c.2038T>A	c.(2038-2040)TCC>ACC	p.S680T	PPAN-P2RY11_uc010xla.1_3'UTR|P2RY11_uc002mnc.2_Missense_Mutation_p.S260T	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	Error:Variant_position_missing_in_Q9NQ55_after_alignment					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			CTACGCCAGCTCCTATGTGCC	0.677													10	78					0	0	0	0	A	10225067	A	A	10225067	3	1	77	1	0	0	0	0	1	0	0	0	12344	1551	54	5		5	PPAN-P2RY11	19	10225067	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	4768908	10225067	48903916	157	15502											
ZNF69	7620	broad.mit.edu	37	chr19	12014459	12014459	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctttgctggatatttcccaGaggaaactctacaaggaagt	12	11	10	8	0	1	1	0	0	1	1	2	4	2	4	1	3	3	2	1	3	5	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:12014459G>A	uc002mst.3	+	2	162	c.93G>A	c.(91-93)CAG>CAA	p.Q31Q		NM_021915	NP_068734	Q9UC07	ZNF69_HUMAN	zinc finger protein 69	45	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				Lung(535;0.011)		ATATTTCCCAGAGGAAACTCT	0.478													12	88					0	0	0	0	A	12014459	A	A	12014459	2	1	77	1	0	0	0	0	0	0	0	1	18162	933	33	2		2	ZNF69	19	12014459	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	1789392	12014459	47114524	158	15503											
CPAMD8	27151	broad.mit.edu	37	chr19	17038880	17038880	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtgtgggacccccagggtGaaggcctcgctgtagctctc	5	8	14	14	2	1	1	0	1	1	0	3	2	1	2	4	3	1	3	4	3	2	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:17038880G>A	uc002nfb.2	-	25	3482	c.3450C>T	c.(3448-3450)TTC>TTT	p.F1150F		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1103						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CCCCCAGGGTGAAGGCCTCGC	0.632													6	57					0	0	0	0	A	17038880	A	A	17038880	2	1	77	1	0	0	0	0	0	0	0	1	3810	1281	45	2		2	CPAMD8	19	17038880	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	5024421	17038880	42090103	159	15504											
HAPLN4	404037	broad.mit.edu	37	chr19	19371769	19371769	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagctcagcccgcccacGgtagctgccgaatgcccggt	6	6	12	17	4	1	0	1	0	0	0	1	1	1	0	4	2	6	4	4	2	2	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:19371769G>A	uc002nmb.2	-	3	392	c.337C>T	c.(337-339)CGT>TGT	p.R113C	HAPLN4_uc002nmc.2_Missense_Mutation_p.R113C	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	113	Ig-like C2-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			GCCCGCCCACGGTAGCTGCCG	0.677													3	57					0	0	0	0	A	19371769	A	A	19371769	3	1	77	1	0	0	0	0	1	0	0	0	6996	1116	39	1	883	1	HAPLN4	19	19371769	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	2332889	19371769	39757214	160	15505											
ZNF30	90075	broad.mit.edu	37	chr19	35435405	35435405	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccatactggtaagaagccctAtgagtgtaaggagtgtggca	12	9	13	7	0	0	2	0	1	0	1	0	3	0	3	2	3	2	3	2	3	5	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:35435405A>T	uc010edp.1	+	5	1913	c.1535A>T	c.(1534-1536)TAT>TTT	p.Y512F	ZNF30_uc002nxf.2_Missense_Mutation_p.Y431F|ZNF30_uc010edq.1_Missense_Mutation_p.Y513F|ZNF30_uc010edr.1_Missense_Mutation_p.Y513F	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	512	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		AAGAAGCCCTATGAGTGTAAG	0.423													4	27					0	0	0	0	T	35435405	T	T	35435405	3	4	77	1	0	0	0	0	1	0	0	0	17897	449	16	5	1552	5	ZNF30	19	35435405	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08	16063636	35435405	23693578	161	15506											
DMKN	93099	broad.mit.edu	37	chr19	36003956	36003956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccccacagccactcacccaaGcaccattgtggccaggcacc	10	4	7	20	0	1	0	1	0	0	0	1	0	1	0	7	2	2	2	7	2	1	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:36003956G>A	uc002nzm.3	-	1	605	c.422C>T	c.(421-423)GCT>GTT	p.A141V	DMKN_uc002nzj.2_5'Flank|DMKN_uc002nzk.3_5'Flank|DMKN_uc002nzl.3_5'Flank|DMKN_uc002nzo.3_Missense_Mutation_p.A141V|DMKN_uc002nzn.3_Missense_Mutation_p.A141V|DMKN_uc002nzw.2_5'Flank|DMKN_uc002nzr.2_5'Flank|DMKN_uc002nzp.2_5'Flank|DMKN_uc002nzq.2_5'Flank|DMKN_uc002nzt.2_5'Flank|DMKN_uc002nzs.2_5'Flank|DMKN_uc002nzu.2_5'Flank|DMKN_uc002nzv.2_5'Flank|DMKN_uc010xsv.1_5'Flank|DMKN_uc010xsw.1_5'Flank|DMKN_uc002nzx.3_5'Flank|DMKN_uc002nzy.3_5'Flank|DMKN_uc002nzz.2_5'Flank|DMKN_uc002oac.3_Missense_Mutation_p.A141V|DMKN_uc010eeb.2_Missense_Mutation_p.A141V|DMKN_uc002oaa.3_Missense_Mutation_p.A141V|DMKN_uc002oab.3_Missense_Mutation_p.A141V	NM_033317	NP_201574	Q6E0U4	DMKN_HUMAN	dermokine isoform 2 precursor	141	Gly-rich.					extracellular region				large_intestine(1)|ovary(1)|skin(1)	3	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			ACTCACCCAAGCACCATTGTG	0.582													8	39					0	0	0	0	A	36003956	A	A	36003956	3	1	77	1	0	0	0	0	1	0	0	0	4604	971	34	4	1389	4	DMKN	19	36003956	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	568551	36003956	23125027	162	15507											
ZNF527	84503	broad.mit.edu	37	chr19	37879433	37879433	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaatctctactgggaaaaGagacaatgaatttagtaatt	17	11	9	4	0	1	2	0	1	1	1	2	5	1	4	0	2	1	1	0	2	8	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:37879433G>C	uc010efk.1	+	5	593	c.482G>C	c.(481-483)AGA>ACA	p.R161T	ZNF527_uc002ogf.3_Missense_Mutation_p.R129T|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACTGGGAAAAGAGACAATGAA	0.383													4	83					0	0	0	0	C	37879433	C	C	37879433	3	2	77	1	0	0	0	0	1	0	0	0	18035	942	33	2	496	2	ZNF527	19	37879433	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	1875477	37879433	21249550	163	15508											
CATSPERG	57828	broad.mit.edu	37	chr19	38849158	38849158	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agggcatcttctgtaacccgTacaacaatctgatcttcatc	11	12	6	12	1	5	1	1	1	4	0	6	1	5	1	1	1	3	3	1	1	4	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:38849158T>C	uc002oih.3	+	13	1540	c.1453T>C	c.(1453-1455)TAC>CAC	p.Y485H	CATSPERG_uc002oig.3_Missense_Mutation_p.Y445H|CATSPERG_uc002oif.3_Missense_Mutation_p.Y125H|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	485	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						CTGTAACCCGTACAACAATCT	0.562													13	70					0	0	0	0	C	38849158	C	C	38849158	3	2	77	1	0	0	0	0	1	0	0	0	2704	1638	57	5	1499	5	CATSPERG	19	38849158	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	969725	38849158	20279825	164	15509											
ZFP112	7771	broad.mit.edu	37	chr19	44832196	44832196	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccagaatggacactctgaTgactctgaaggtatgatctc	11	11	9	10	0	3	5	0	4	3	1	5	6	4	6	1	2	0	1	1	2	3	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:44832196T>G	uc010ejj.2	-	5	2245	c.2132A>C	c.(2131-2133)CAT>CCT	p.H711P	ZFP112_uc002ozc.3_Missense_Mutation_p.H705P|ZFP112_uc010xwy.1_Missense_Mutation_p.H728P|ZFP112_uc010xwz.1_Missense_Mutation_p.H710P	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	711	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						GACACTCTGATGACTCTGAAG	0.458													8	106					0	0	0	0	G	44832196	G	G	44832196	3	3	77	1	0	0	0	0	1	0	0	0	17705	1464	51	5	613	5	ZFP112	19	44832196	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	5983038	44832196	14296787	165	15510											
PNMAL2	57469	broad.mit.edu	37	chr19	46998632	46998632	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcttcgacgtctgcctgctCcaggccctccgggatgccgg	3	8	14	16	4	1	0	0	0	1	0	4	2	3	1	5	4	3	2	5	4	0	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:46998632C>T	uc002pes.2	-	1	538	c.91G>A	c.(91-93)GAG>AAG	p.E31K	uc002peu.1_3'UTR	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	31										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		tctgcctgctccaggccctcc	0.03													27	56					0	0	0	0	T	46998632	T	T	46998632	3	4	77	1	0	0	0	0	1	0	0	0	12213	864	30	2	1820	2	PNMAL2	19	46998632	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	2166436	46998632	12130351	166	15511											
DHX34	9704	broad.mit.edu	37	chr19	47856504	47856504	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctgcagagattccagaatCtcaagacctccaggaaggag	13	6	11	11	0	1	3	1	0	1	3	4	6	3	5	4	2	1	1	4	2	3	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:47856504C>G	uc010xyn.1	+	2	558	c.217C>G	c.(217-219)CTC>GTC	p.L73V	DHX34_uc010elc.1_Missense_Mutation_p.L73V	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	73						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		ATTCCAGAATCTCAAGACCTC	0.537													4	111					0	0	0	0	G	47856504	G	G	47856504	3	3	77	1	0	0	0	0	1	0	0	0	4529	913	32	2	219	2	DHX34	19	47856504	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	857872	47856504	11272479	167	15512											
PEG3	5178	broad.mit.edu	37	chr19	57327205	57327205	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatcttctgtcgcttatcatTaaggtctgagatataaatgg	12	15	8	6	1	4	1	1	1	3	1	5	2	4	1	0	2	0	1	0	2	6	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:57327205T>G	uc002qnu.2	-	7	2956	c.2605A>C	c.(2605-2607)AAT>CAT	p.N869H	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.N840H|PEG3_uc002qnv.2_Missense_Mutation_p.N869H|PEG3_uc002qnw.2_Missense_Mutation_p.N745H|PEG3_uc002qnx.2_Missense_Mutation_p.N743H|PEG3_uc010etr.2_Missense_Mutation_p.N869H	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	869					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CGCTTATCATTAAGGTCTGAG	0.438													9	76					0	0	0	0	G	57327205	G	G	57327205	3	3	77	1	0	0	0	0	1	0	0	0	11774	1754	61	5	2165	5	PEG3	19	57327205	Missense_Mutation	SNP	T	TCGA-CN-6020-01A-11D-1683-08	9470701	57327205	1801778	168	15513											
ZNF749	388567	broad.mit.edu	37	chr19	57955191	57955191	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatggggagaggccttatgaGttcagtgaatgtggggaatt	11	11	16	3	0	1	3	1	2	0	1	1	5	1	4	1	5	0	1	1	5	4	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr19:57955191G>A	uc002qoq.2	+	3	929	c.675G>A	c.(673-675)GAG>GAA	p.E225E	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	225	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		GGCCTTATGAGTTCAGTGAAT	0.428													13	56					0	0	0	0	A	57955191	A	A	57955191	2	1	77	1	0	0	0	0	0	0	0	1	18198	1020	36	4		4	ZNF749	19	57955191	Silent	SNP	G	TCGA-CN-6020-01A-11D-1683-08	627986	57955191	1173792	169	15514											
SLC23A2	9962	broad.mit.edu	37	chr20	4855261	4855261	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaacttgtacgcagtccaTcctttcttggatttataaat	10	17	6	8	1	1	0	0	0	1	0	3	1	3	1	2	1	2	3	2	1	5	8			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr20:4855261T>A	uc002wlg.1	-	10	1281	c.906A>T	c.(904-906)GGA>GGT	p.G302G	SLC23A2_uc010zqr.1_Silent_p.G187G|SLC23A2_uc002wlh.1_Silent_p.G302G|SLC23A2_uc002wli.2_Silent_p.G301G	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	302					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						ACGCAGTCCATCCTTTCTTGG	0.383													7	131					0	0	0	0	A	4855261	A	A	4855261	2	1	77	1	0	0	0	0	0	0	0	1	14527	1422	50	5		5	SLC23A2	20	4855261	Silent	SNP	T	TCGA-CN-6020-01A-11D-1683-08		4855261	58170259	170	15515											
ZNFX1	57169	broad.mit.edu	37	chr20	47888006	47888006	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attggaccatggtggtctgcGgttcctacagtcctggttgc	5	13	13	10	1	1	0	0	0	1	0	3	1	3	1	3	5	3	2	3	5	1	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr20:47888006G>A	uc002xui.2	-	3	590	c.343C>T	c.(343-345)CGC>TGC	p.R115C		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	115							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGTGGTCTGCGGTTCCTACAG	0.557													19	244					0	0	0	0	A	47888006	A	A	47888006	3	1	77	1	0	0	0	0	1	0	0	0	18272	1116	39	1	5461	1	ZNFX1	20	47888006	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	43032745	47888006	15137514	171	15516											
SALL4	57167	broad.mit.edu	37	chr20	50407919	50407919	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgggtttgacatccaccGcggagatgttcggtggcttc	5	13	13	10	3	0	2	0	1	0	1	3	3	1	2	2	4	0	3	2	4	0	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr20:50407919G>A	uc002xwh.3	-	2	1204	c.1103C>T	c.(1102-1104)GCG>GTG	p.A368V	SALL4_uc010gii.2_Missense_Mutation_p.A368V|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	368					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GACATCCACCGCGGAGATGTT	0.562													8	56					0	0	0	0	A	50407919	A	A	50407919	3	1	77	1	0	0	0	0	1	0	0	0	13878	1087	38	1	2070	1	SALL4	20	50407919	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	2519913	50407919	12617601	172	15517											
BAGE2	85319	broad.mit.edu	37	chr21	11049619	11049619	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcacagtttgcatcttcctTcgctataattaacagtaaaa	13	14	5	9	1	1	0	0	0	1	0	3	0	2	0	1	0	3	5	1	0	5	7			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr21:11049619T>A	uc002yit.1	-	4	490	c.282A>T	c.(280-282)CGA>CGT	p.R94R		NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCATCTTCCTTCGCTATAATT	0.373													7	205					0	0	0	0	A	11049619	A	A	11049619	2	1	77	1	0	0	0	0	0	0	0	1	1294	1770	62	5		5	BAGE2	21	11049619	Silent	SNP	T	TCGA-CN-6020-01A-11D-1683-08		11049619	37080276	173	15518											
GNB1L	54584	broad.mit.edu	37	chr22	19808242	19808242	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgtgtaccaggccactctGagacctgtttcagacaagcc	10	9	10	12	0	2	2	1	1	1	2	2	4	2	2	4	1	2	2	4	1	2	2			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr22:19808242G>A	uc002zqe.1	-	3	527	c.133C>T	c.(133-135)CAG>TAG	p.Q45*	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqf.1_Nonsense_Mutation_p.Q45*	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	45	WD 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					AGGCCACTCTGAGACCTGTTT	0.642													7	57					0	0	0	0	A	19808242	A	A	19808242	4	1	77	1	0	0	0	0	0	1	0	0	6553	1299	45	2	870	2	GNB1L	22	19808242	Nonsense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08		19808242	31496324	174	15519											
RFPL3	10738	broad.mit.edu	37	chr22	32756539	32756539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtttgagggatggaagccGcctctctgccagcacggtgc	7	8	15	11	2	1	1	0	1	1	0	2	4	1	3	3	3	4	2	3	3	1	1			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr22:32756539G>A	uc003amj.2	+	2	879	c.674G>A	c.(673-675)CGC>CAC	p.R225H	RFPL3_uc010gwn.2_Missense_Mutation_p.R196H|RFPL3S_uc003amk.2_RNA|RFPL3S_uc003aml.2_RNA	NM_001098535	NP_001092005	O75679	RFPL3_HUMAN	ret finger protein-like 3 isoform 1	225	B30.2/SPRY.						zinc ion binding			ovary(1)	1						GATGGAAGCCGCCTCTCTGCC	0.527													15	71					0	0	0	0	A	32756539	A	A	32756539	3	1	77	1	0	0	0	0	1	0	0	0	13320	1087	38	1	680	1	RFPL3	22	32756539	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	12948297	32756539	18548027	175	15520											
KCNJ4	3761	broad.mit.edu	37	chr22	38823566	38823566	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcgcgcaccgaaatgaccGcgtggtggctgaacagcaac	10	5	13	13	6	0	2	0	2	0	0	1	3	0	2	2	2	3	3	2	2	3	0			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chr22:38823566G>A	uc003avs.1	-	2	669	c.572C>T	c.(571-573)GCG>GTG	p.A191V	KCNJ4_uc003avt.1_Missense_Mutation_p.A191V	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	191	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					CGAAATGACCGCGTGGTGGCT	0.637													4	30					0	0	0	0	A	38823566	A	A	38823566	3	1	77	1	0	0	0	0	1	0	0	0	8092	1087	38	1	769	1	KCNJ4	22	38823566	Missense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	6067027	38823566	12481000	176	15521											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29417365	29417365	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagatgacattggaaattatAcctgtgaattaaaatatgga	18	12	8	3	0	0	3	0	2	0	1	0	5	0	5	1	2	1	0	1	2	8	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chrX:29417365A>G	uc004dby.2	+	5	1151	c.643A>G	c.(643-645)ACC>GCC	p.T215A		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	215	Ig-like C2-type 2.|Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TGGAAATTATACCTGTGAATT	0.343													8	28					0	0	0	0	G	29417365	G	G	29417365	3	3	77	1	0	0	0	0	1	0	0	0	7700	391	14	5	657	5	IL1RAPL1	23	29417365	Missense_Mutation	SNP	A	TCGA-CN-6020-01A-11D-1683-08		29417365	125853195	177	15522											
FAM47A	158724	broad.mit.edu	37	chrX	34148157	34148157	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gatgccaggcatttcatagcCcttgcttagaatgaaatcct	11	12	8	10	0	1	2	1	1	0	1	2	3	2	2	3	1	3	2	3	1	4	4			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chrX:34148157C>A	uc004ddg.2	-	1	2272	c.2239G>T	c.(2239-2241)GGC>TGC	p.G747C		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	747										ovary(4)|central_nervous_system(1)	5						ATTTCATAGCCCTTGCTTAGA	0.408													14	68					4.3838e-07	4.8559e-07	1	0	A	34148157	A	A	34148157	3	1	77	1	0	0	0	0	1	0	0	0	5601	623	22	4	140	4	FAM47A	23	34148157	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	4730792	34148157	121122403	178	15523											
IL1RAPL2	26280	broad.mit.edu	37	chrX	105011054	105011054	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agacggggatggagtattttCgaactggaaagcagactcca	13	8	13	7	2	0	2	0	0	0	2	2	6	1	5	1	4	2	2	1	4	3	3			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chrX:105011054C>T	uc004elz.1	+	11	2217	c.1461C>T	c.(1459-1461)TTC>TTT	p.F487F		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	487	Cytoplasmic (Potential).|TIR.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						GGAGTATTTTCGAACTGGAAA	0.388													10	41					0	0	0	0	T	105011054	T	T	105011054	2	4	77	1	0	0	0	0	0	0	0	1	7701	883	31	1		1	IL1RAPL2	23	105011054	Silent	SNP	C	TCGA-CN-6020-01A-11D-1683-08	70862897	105011054	50259506	179	15524											
MUM1L1	139221	broad.mit.edu	37	chrX	105450642	105450642	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atatcagaaatatccattttGgccagcagtgataaaaagta	17	11	7	6	0	1	2	1	1	0	1	2	2	2	2	2	1	1	2	2	1	7	6			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chrX:105450642G>A	uc004emf.1	+	4	1866	c.1217G>A	c.(1216-1218)TGG>TAG	p.W406*	MUM1L1_uc004emg.1_Nonsense_Mutation_p.W406*	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	406	PWWP.									ovary(2)|pancreas(1)|skin(1)	4						TATCCATTTTGGCCAGCAGTG	0.368													4	4					0	0	0	0	A	105450642	A	A	105450642	4	1	77	1	0	0	0	0	0	1	0	0	10039	1357	47	4	1219	4	MUM1L1	23	105450642	Nonsense_Mutation	SNP	G	TCGA-CN-6020-01A-11D-1683-08	439588	105450642	49819918	180	15525											
DOCK11	139818	broad.mit.edu	37	chrX	117775257	117775257	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaccatatcatttttcactCagtgcttcaaggtaaaaatg	14	13	5	9	0	4	0	4	0	0	0	4	0	4	0	1	1	1	2	1	1	5	5			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chrX:117775257C>T	uc004eqp.2	+	39	4312	c.4249C>T	c.(4249-4251)CAG>TAG	p.Q1417*	DOCK11_uc004eqq.2_Nonsense_Mutation_p.Q1196*	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1417					blood coagulation	cytosol	GTP binding			ovary(3)	3						ATTTTTCACTCAGTGCTTCAA	0.323													6	36					0	0	0	0	T	117775257	T	T	117775257	4	4	77	1	0	0	0	0	0	1	0	0	4708	827	29	2	4403	2	DOCK11	23	117775257	Nonsense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	12324615	117775257	37495303	181	15526											
ZNF75D	7626	broad.mit.edu	37	chrX	134421749	134421749	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaacagatataggatgatCatttccagtgtcatttttta	14	15	7	5	0	2	3	2	1	0	2	3	4	3	4	1	1	1	0	1	1	4	6			TCGA-CN-6020-01A-11D-1683-08	TCGA-CN-6020-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f33c4c7-4f08-44a2-91f5-7ed2d7da68f0	6cfc6be3-b8b6-4934-aa2f-7d2e7fd53ec2	g.chrX:134421749C>T	uc004eyp.2	-	7	3508	c.853G>A	c.(853-855)GAT>AAT	p.D285N	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_Missense_Mutation_p.D64N|ZNF75D_uc004eyo.2_Missense_Mutation_p.D190N	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	285	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ATAGGATGATCATTTCCAGTG	0.363													4	38					0	0	0	0	T	134421749	T	T	134421749	3	4	77	1	0	0	0	0	1	0	0	0	18201	826	29	2	683	2	ZNF75D	23	134421749	Missense_Mutation	SNP	C	TCGA-CN-6020-01A-11D-1683-08	16646492	134421749	20848811	182	15527											
PRAMEF4	400735	broad.mit.edu	37	chr1	12939818	12939818	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctgatgccactcaggtcCagggtctttagttgactgat	8	13	11	9	0	3	3	1	3	2	0	4	3	4	3	2	2	1	1	2	2	1	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:12939818C>T	uc001aun.2	-	4	1055	c.984G>A	c.(982-984)CTG>CTA	p.L328L		NM_001009611	NP_001009611	O60810	PRAM4_HUMAN	PRAME family member 4	328	LRR 4.									ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACTCAGGTCCAGGGTCTTTA	0.448													58	80					0	0	0	0	T	12939818	T	T	12939818	2	4	78	1	0	0	0	0	0	0	0	1	12499	581	21	4		4	PRAMEF4	1	12939818	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08		12939818	236310803	1	15528											
FBXO42	54455	broad.mit.edu	37	chr1	16580134	16580134	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaattcctgagcacctgaGattggccacctcgaggatga	10	11	10	10	1	0	3	0	3	0	1	2	6	1	4	4	2	1	1	4	2	1	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:16580134G>T	uc001ayg.2	-	7	1076	c.860C>A	c.(859-861)TCT>TAT	p.S287Y	FBXO42_uc001aye.3_5'UTR|FBXO42_uc001ayf.2_Missense_Mutation_p.S194Y	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	287	Kelch 3.									upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		GAGCACCTGAGATTGGCCACC	0.517													12	17					5.50884e-06	6.04246e-06	1	0	T	16580134	T	T	16580134	3	4	78	1	0	0	0	0	1	0	0	0	5783	942	33	2	1309	2	FBXO42	1	16580134	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	3640316	16580134	232670487	2	15529											
KIF17	57576	broad.mit.edu	37	chr1	20992741	20992741	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcgtctgtgctgaggatctgGctggcccgcttagatcggaa	6	10	15	10	3	2	2	0	1	2	1	3	4	2	4	1	4	1	3	1	4	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:20992741G>A	uc001bdr.3	-	14	2995	c.2877C>T	c.(2875-2877)AGC>AGT	p.S959S	KIF17_uc001bdp.3_Silent_p.S236S|KIF17_uc001bdq.3_Silent_p.S237S|KIF17_uc009vpx.2_Silent_p.S329S|KIF17_uc001bds.3_Silent_p.S958S	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	959					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TGAGGATCTGGCTGGCCCGCT	0.572													31	43					0	0	0	0	A	20992741	A	A	20992741	2	1	78	1	0	0	0	0	0	0	0	1	8318	1194	42	4		4	KIF17	1	20992741	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	4412607	20992741	228257880	3	15530											
ZC3H12A	80149	broad.mit.edu	37	chr1	37948750	37948750	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attggctccctggagagccaGatgtcggaactttggggggt	7	10	16	8	1	0	2	0	0	0	2	2	4	1	3	2	6	2	1	2	6	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:37948750G>A	uc001cbb.3	+	6	1488	c.1338G>A	c.(1336-1338)CAG>CAA	p.Q446Q	ZC3H12A_uc001cbc.1_Silent_p.Q241Q	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	446					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGAGAGCCAGATGTCGGAAC	0.647													3	44					0	0	0	0	A	37948750	A	A	37948750	2	1	78	1	0	0	0	0	0	0	0	1	17628	933	33	2		2	ZC3H12A	1	37948750	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	16956009	37948750	211301871	4	15531											
PRKAA2	5563	broad.mit.edu	37	chr1	57170082	57170082	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcttggaatccgaagtcaGagcaaaccgtatgacattat	14	10	8	9	2	2	2	1	1	1	1	3	4	3	3	2	1	2	2	2	1	5	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:57170082G>C	uc001cyk.3	+	7	1298	c.1227G>C	c.(1225-1227)CAG>CAC	p.Q409H		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	409					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						TCCGAAGTCAGAGCAAACCGT	0.408													41	34					0	0	0	0	C	57170082	C	C	57170082	3	2	78	1	0	0	0	0	1	0	0	0	12556	933	33	2	1253	2	PRKAA2	1	57170082	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	19221332	57170082	192080539	5	15532											
C8B	732	broad.mit.edu	37	chr1	57399015	57399015	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgaaagtggtacctttcagGacagggactccatttccttg	9	12	10	10	0	1	1	1	1	0	0	3	3	3	3	3	3	1	1	3	3	2	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:57399015G>A	uc001cyp.2	-	10	1612	c.1545C>T	c.(1543-1545)GTC>GTT	p.V515V	C8B_uc010oon.1_Silent_p.V453V|C8B_uc010ooo.1_Silent_p.V463V	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	515	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TACCTTTCAGGACAGGGACTC	0.552													17	30					0	0	0	0	A	57399015	A	A	57399015	2	1	78	1	0	0	0	0	0	0	0	1	2428	1161	41	2		2	C8B	1	57399015	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	228933	57399015	191851606	6	15533											
LHX8	431707	broad.mit.edu	37	chr1	75622595	75622595	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggtgtggtttcagaattgTagagcacgccacaagaaaca	14	8	11	8	1	1	3	1	0	0	3	1	3	1	3	1	2	2	3	1	2	4	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:75622595T>C	uc001dgo.2	+	9	1492	c.828T>C	c.(826-828)TGT>TGC	p.C276C	LHX8_uc001dgq.2_Silent_p.C215C	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	276	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TTCAGAATTGTAGAGCACGCC	0.473													42	43					0	0	0	0	C	75622595	C	C	75622595	2	2	78	1	0	0	0	0	0	0	0	1	8817	1644	57	5		5	LHX8	1	75622595	Silent	SNP	T	TCGA-CN-6021-01A-11D-1683-08	18223580	75622595	173628026	7	15534											
SLC44A5	204962	broad.mit.edu	37	chr1	75716976	75716976	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagtaaaacaaaatggtcttGttcctgttaagaaagaaaac	19	10	7	5	0	1	2	0	0	1	2	2	2	2	2	1	1	2	3	1	1	9	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:75716976G>A	uc001dgu.2	-	7	408	c.264C>T	c.(262-264)AAC>AAT	p.N88N	SLC44A5_uc001dgt.2_Silent_p.N88N|SLC44A5_uc001dgs.2_Silent_p.N46N|SLC44A5_uc001dgr.2_Silent_p.N46N|SLC44A5_uc010oqz.1_Silent_p.N127N|SLC44A5_uc010ora.1_Silent_p.N82N|SLC44A5_uc010orb.1_5'UTR	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	88	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						AAATGGTCTTGTTCCTGTTAA	0.378													13	26					0	0	0	0	A	75716976	A	A	75716976	2	1	78	1	0	0	0	0	0	0	0	1	14703	1368	48	4		4	SLC44A5	1	75716976	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	94381	75716976	173533645	8	15535											
LCE1A	353131	broad.mit.edu	37	chr1	152800095	152800095	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcagtgtcagctccggAggctgctgtggctccagctc	4	10	14	13	1	1	0	1	0	0	0	4	1	3	1	2	3	5	7	2	3	0	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:152800095A>G	uc010pdw.1	+	1	147	c.147A>G	c.(145-147)GGA>GGG	p.G49G		NM_178348	NP_848125	Q5T7P2	LCE1A_HUMAN	late cornified envelope 1A	49	Cys-rich.				keratinization					ovary(1)|skin(1)	2	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCAGCTCCGGAGGCTGCTGTG	0.453													20	39					0	0	0	0	G	152800095	G	G	152800095	2	3	78	1	0	0	0	0	0	0	0	1	8699	291	11	5		5	LCE1A	1	152800095	Silent	SNP	A	TCGA-CN-6021-01A-11D-1683-08	77083119	152800095	96450526	9	15536											
ATP8B2	57198	broad.mit.edu	37	chr1	154318808	154318808	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcatctgcatcgcccaGggcatctacacctccgtgct	6	12	7	16	2	4	0	1	0	3	0	6	0	5	0	3	1	3	3	3	1	1	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:154318808G>C	uc001fex.2	+	25	2979	c.2979G>C	c.(2977-2979)CAG>CAC	p.Q993H		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	979	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCATCGCCCAGGGCATCTACA	0.562													22	52					0	0	0	0	C	154318808	C	C	154318808	3	2	78	1	0	0	0	0	1	0	0	0	1197	991	35	4	3207	4	ATP8B2	1	154318808	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1518713	154318808	94931813	10	15537											
SPTA1	6708	broad.mit.edu	37	chr1	158624459	158624459	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcttcatggtgacttctcggGggctgcgggcctggaagtca	5	11	15	10	2	4	1	2	1	2	0	5	2	4	2	1	5	1	1	1	5	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:158624459G>T	uc001fst.1	-	21	3177	c.2978C>A	c.(2977-2979)CCC>CAC	p.P993H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	993	SH3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GACTTCTCGGGGGCTGCGGGC	0.468													11	25					9.31168e-06	1.01846e-05	1	0	T	158624459	T	T	158624459	3	4	78	1	0	0	0	0	1	0	0	0	15182	1232	43	4	4409	4	SPTA1	1	158624459	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	4305651	158624459	90626162	11	15538											
OR6K3	391114	broad.mit.edu	37	chr1	158687951	158687951	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagagggcatagtccagcaCatgagagggtagagaaaaaa	17	4	15	5	0	0	3	0	1	0	3	1	6	1	3	1	3	1	3	1	3	5	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:158687951C>G	uc010pip.1	-	1	3	c.3G>C	c.(1-3)ATG>ATC	p.M1I		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					TAGTCCAGCACATGAGAGGGT	0.373													16	33					0	0	0	0	G	158687951	G	G	158687951	3	3	78	1	0	0	0	0	1	0	0	0	11257	493	17	4		4	OR6K3	1	158687951	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	63492	158687951	90562670	12	15539											
SELP	6403	broad.mit.edu	37	chr1	169572441	169572441	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcttagcaaaggtgtgcAgggaatggctatcatgggca	11	8	16	6	0	1	0	1	0	0	0	1	1	1	1	0	5	2	5	0	5	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:169572441A>G	uc001ggi.3	-	10	1593	c.1528T>C	c.(1528-1530)TGC>CGC	p.C510R	SELP_uc001ggh.2_Missense_Mutation_p.C345R|SELP_uc009wvr.2_Missense_Mutation_p.C510R	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	510	Extracellular (Potential).|Sushi 6.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	AAAGGTGTGCAGGGAATGGCT	0.378													17	62					0	0	0	0	G	169572441	G	G	169572441	3	3	78	1	0	0	0	0	1	0	0	0	14084	188	7	5	992	5	SELP	1	169572441	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	10884490	169572441	79678180	13	15540											
SELP	6403	broad.mit.edu	37	chr1	169586578	169586578	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgattctggcagtatttacGggaaatattccatgagtatg	11	13	11	6	2	1	1	0	1	1	0	2	3	2	2	1	2	1	3	1	2	5	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:169586578G>C	uc001ggi.3	-	3	234	c.169C>G	c.(169-171)CGT>GGT	p.R57G	SELP_uc001ggh.2_5'UTR|SELP_uc009wvr.2_Missense_Mutation_p.R57G	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	57	Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CAGTATTTACGGGAAATATTC	0.408													46	104					0	0	0	0	C	169586578	C	C	169586578	3	2	78	1	0	0	0	0	1	0	0	0	14084	1116	39	3	2379	3	SELP	1	169586578	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	14137	169586578	79664043	14	15541											
METTL13	51603	broad.mit.edu	37	chr1	171756906	171756906	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtctgtgggtggggacattgGggtccggaccgttcagcacc	5	9	17	10	2	2	0	1	0	1	0	3	2	3	2	3	6	1	2	3	6	0	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:171756906G>T	uc001ghz.2	+	4	1492	c.1145G>T	c.(1144-1146)GGG>GTG	p.G382V	METTL13_uc001gia.2_Missense_Mutation_p.G296V|METTL13_uc001gib.2_Missense_Mutation_p.G226V|METTL13_uc010pml.1_Missense_Mutation_p.G381V	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	382							methyltransferase activity|protein binding			kidney(1)	1						GGGGACATTGGGGTCCGGACC	0.502													12	27					1.05317e-09	1.2671e-09	1	0	T	171756906	T	T	171756906	3	4	78	1	0	0	0	0	1	0	0	0	9550	1232	43	4	1159	4	METTL13	1	171756906	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2170328	171756906	77493715	15	15542											
RC3H1	149041	broad.mit.edu	37	chr1	173907909	173907909	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctctgggagtcattattatCccctcctccctcagggtcct	5	14	7	15	0	3	0	2	0	1	0	8	1	7	1	5	2	0	0	5	2	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:173907909C>A	uc001gju.3	-	19	3439	c.3352G>T	c.(3352-3354)GAT>TAT	p.D1118Y	RC3H1_uc010pms.1_Missense_Mutation_p.D1109Y|RC3H1_uc001gjv.2_Missense_Mutation_p.D1110Y|RC3H1_uc010pmt.1_Missense_Mutation_p.D1119Y	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	1118					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TCATTATTATCCCCTCCTCCC	0.463													16	68					1.5739e-10	1.93594e-10	1	0	A	173907909	A	A	173907909	3	1	78	1	0	0	0	0	1	0	0	0	13231	855	30	2	53	2	RC3H1	1	173907909	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	2151003	173907909	75342712	16	15543											
KCNT2	343450	broad.mit.edu	37	chr1	196303004	196303004	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgaagacatttcttcatctGgtgtagtttcatcttctgat	8	19	7	7	0	6	3	2	2	4	1	6	3	6	3	0	1	0	2	0	1	2	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:196303004G>C	uc001gtd.1	-	17	2030	c.1970C>G	c.(1969-1971)CCA>CGA	p.P657R	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.P607R|KCNT2_uc001gtf.1_Missense_Mutation_p.P657R|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.P657R|KCNT2_uc001gth.1_Missense_Mutation_p.P178R	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	657	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TTCTTCATCTGGTGTAGTTTC	0.353													5	24					0	0	0	0	C	196303004	C	C	196303004	3	2	78	1	0	0	0	0	1	0	0	0	8131	1348	47	4	1485	4	KCNT2	1	196303004	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	22395095	196303004	52947617	17	15544											
CFHR4	10877	broad.mit.edu	37	chr1	196882035	196882035	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttgcaaaatggatggtcagCacaaccaatttgcattagta	14	12	8	7	0	1	0	1	0	0	0	1	1	1	1	1	2	4	4	1	2	6	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:196882035C>T	uc001gto.2	+	3	491	c.422C>T	c.(421-423)GCA>GTA	p.A141V	CFHR4_uc009wyy.2_Missense_Mutation_p.A387V|CFHR4_uc001gtp.2_Missense_Mutation_p.A388V	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	141	Sushi 2.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						GGATGGTCAGCACAACCAATT	0.299													35	95					0	0	0	0	T	196882035	T	T	196882035	3	4	78	1	0	0	0	0	1	0	0	0	3302	710	25	4	432	4	CFHR4	1	196882035	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	579031	196882035	52368586	18	15545											
CRB1	23418	broad.mit.edu	37	chr1	197390936	197390936	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccctggagaacatctcgTctggctcatcattaaatgtc	10	13	7	11	1	4	1	2	0	2	1	6	2	4	1	1	2	2	1	1	2	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:197390936T>A	uc001gtz.2	+	6	2113	c.1978T>A	c.(1978-1980)TCT>ACT	p.S660T	CRB1_uc010poz.1_Missense_Mutation_p.S591T|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.S548T|CRB1_uc010ppb.1_Missense_Mutation_p.S660T|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.S141T|CRB1_uc001gub.1_Missense_Mutation_p.S309T	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	660	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GAACATCTCGTCTGGCTCATC	0.443													35	68					0	0	0	0	A	197390936	A	A	197390936	3	1	78	1	0	0	0	0	1	0	0	0	3863	1667	58	5	2000	5	CRB1	1	197390936	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	508901	197390936	51859685	19	15546											
PLXNA2	5362	broad.mit.edu	37	chr1	208218554	208218554	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caggagggcagaggtttttgCcctgtagagaatagcagtct	10	10	14	7	0	1	2	0	0	1	2	1	4	1	3	1	3	2	4	1	3	3	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:208218554C>T	uc001hgz.2	-	19	4255	c.3497G>A	c.(3496-3498)GGC>GAC	p.G1166D		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1166	IPT/TIG 4.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GAGGTTTTTGCCCTGTAGAGA	0.388													3	77					0	0	0	0	T	208218554	T	T	208218554	3	4	78	1	0	0	0	0	1	0	0	0	12175	753	26	4	2243	4	PLXNA2	1	208218554	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	10827618	208218554	41032067	20	15547											
LYST	1130	broad.mit.edu	37	chr1	235850334	235850334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcaactgtcaggcacccaaGcacaactagtcacctttgaa	13	7	8	13	0	2	1	2	1	0	0	2	1	2	1	2	2	3	3	2	2	5	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:235850334G>A	uc001hxj.2	-	48	10890	c.10715C>T	c.(10714-10716)GCT>GTT	p.A3572V	LYST_uc001hxi.2_Missense_Mutation_p.A796V	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3572	WD 3.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AGGCACCCAAGCACAACTAGT	0.363									Chediak-Higashi_syndrome				4	92					0	0	0	0	A	235850334	A	A	235850334	3	1	78	1	0	0	0	0	1	0	0	0	9179	971	34	4	714	4	LYST	1	235850334	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	27631780	235850334	13400287	21	15548											
RGS7	6000	broad.mit.edu	37	chr1	240979618	240979618	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcataggttgactcaccTgttgttgtaactcatcttct	8	17	6	10	0	5	1	3	1	3	0	6	1	5	1	1	1	1	4	1	1	2	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:240979618T>A	uc001hyv.2	-	11	1112	c.782A>T	c.(781-783)CAG>CTG	p.Q261L	RGS7_uc010pyh.1_Missense_Mutation_p.Q235L|RGS7_uc010pyj.1_Missense_Mutation_p.Q177L|RGS7_uc001hyu.2_Missense_Mutation_p.Q261L|RGS7_uc009xgn.1_Missense_Mutation_p.Q208L|RGS7_uc001hyw.2_Missense_Mutation_p.Q261L|RGS7_uc001hyt.2_Missense_Mutation_p.Q93L	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	261	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TTGACTCACCTGTTGTTGTAA	0.373													30	91					0	0	0	0	A	240979618	A	A	240979618	3	1	78	1	0	0	0	0	1	0	0	0	13375	1594	55	5	713	5	RGS7	1	240979618	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	5129284	240979618	8271003	22	15549											
RGS7	6000	broad.mit.edu	37	chr1	241099909	241099909	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aataaacttacttgaaaccgGtaaaaggtgccatcatcctt	15	11	6	9	1	1	1	1	1	0	0	2	1	2	1	3	2	4	1	3	2	7	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:241099909G>T	uc001hyv.2	-	5	654	c.324C>A	c.(322-324)TAC>TAA	p.Y108*	RGS7_uc010pyh.1_Nonsense_Mutation_p.Y82*|RGS7_uc010pyj.1_Nonsense_Mutation_p.Y24*|RGS7_uc001hyu.2_Nonsense_Mutation_p.Y108*|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Nonsense_Mutation_p.Y108*	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	108	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CTTGAAACCGGTAAAAGGTGC	0.403													15	58					2.31682e-05	2.49853e-05	1	0	T	241099909	T	T	241099909	4	4	78	1	0	0	0	0	0	1	0	0	13375	1256	44	4	1195	4	RGS7	1	241099909	Nonsense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	120291	241099909	8150712	23	15550											
OR2M2	391194	broad.mit.edu	37	chr1	248343753	248343753	+	Frame_Shift_Del	DEL	G	-	-																															ggatcctgggctctacagatGgaatcattgatgctgtagcc																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:248343753delG	uc010pzf.1	+	1	466	c.466delG	c.(466-468)GGAfs	p.G156fs		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTCTACAGATGGAATCATTGA	0.433													---	---	---								-	248343753	-	-	248343753	7	5	78	1	0	1	0	1	0	0	0	0	11064	1349	47	0	468	0	OR2M2	1	248343753	Frame_Shift_Del	DEL	G	TCGA-CN-6021-01A-11D-1683-08	7243844	248343753	906868	24	15551											
OR2T1	26696	broad.mit.edu	37	chr1	248569749	248569749	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggggtgcacagctcaacacTtcctctaccttacccttgtg	7	12	8	14	0	2	0	1	0	1	0	3	0	3	0	3	2	5	2	3	2	3	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr1:248569749T>C	uc010pzm.1	+	1	454	c.454T>C	c.(454-456)TTC>CTC	p.F152L		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	152	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGCTCAACACTTCCTCTACCT	0.478													43	104					0	0	0	0	C	248569749	C	C	248569749	3	2	78	1	0	0	0	0	1	0	0	0	11070	1609	56	5	456	5	OR2T1	1	248569749	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	225996	248569749	680872	25	15552											
TPO	7173	broad.mit.edu	37	chr2	1440052	1440052	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaagatctgctgagcatCattgcaaacatgtctggatg	12	11	10	8	0	4	3	2	1	2	2	4	4	4	4	0	1	4	3	0	1	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:1440052C>A	uc002qww.2	+	5	469	c.378C>A	c.(376-378)ATC>ATA	p.I126I	TPO_uc010ewj.2_Intron|TPO_uc010yin.1_Silent_p.I126I|TPO_uc002qwu.2_Silent_p.I126I|TPO_uc002qwr.2_Silent_p.I126I|TPO_uc002qwx.2_Silent_p.I126I|TPO_uc010yio.1_Silent_p.I126I|TPO_uc010yip.1_Silent_p.I126I	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	126	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGCTGAGCATCATTGCAAACA	0.433													29	60					1.16021e-09	1.39153e-09	1	0	A	1440052	A	A	1440052	2	1	78	1	0	0	0	0	0	0	0	1	16477	816	29	2		2	TPO	2	1440052	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08		1440052	241759321	26	15553											
DDX1	1653	broad.mit.edu	37	chr2	15758345	15758345	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttattctgattttataaataGgatgcacaatcagattcctc	13	16	5	7	0	2	2	1	1	1	1	4	3	3	3	1	1	1	1	1	1	6	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:15758345G>A	uc002rce.2	+	16	1445	c.1157G>A	c.(1156-1158)AGG>AAG	p.R386K	DDX1_uc010yjq.1_Missense_Mutation_p.R294K	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	386	Necessary for interaction with RELA.|Helicase ATP-binding.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		TTTATAAATAGGATGCACAAT	0.299													38	116					0	0	0	0	A	15758345	A	A	15758345	3	1	78	1	0	0	0	0	1	0	0	0	4358	1000	35	4	1219	4	DDX1	2	15758345	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	14318293	15758345	227441028	27	15554											
FAM179A	165186	broad.mit.edu	37	chr2	29255814	29255814	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggcagattttatggccggaAgatggtgaatatcttgatgg	10	13	14	4	1	1	4	0	2	1	2	1	5	1	5	1	5	0	1	1	5	4	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:29255814A>G	uc010ezl.2	+	15	2378	c.2027A>G	c.(2026-2028)AAG>AGG	p.K676R	FAM179A_uc010ymm.1_Missense_Mutation_p.K621R|FAM179A_uc002rmr.3_Missense_Mutation_p.K203R|FAM179A_uc002rms.1_5'Flank	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	676							binding			ovary(3)|skin(1)	4						TATGGCCGGAAGATGGTGAAT	0.403													4	14					0	0	0	0	G	29255814	G	G	29255814	3	3	78	1	0	0	0	0	1	0	0	0	5533	72	3	5	2081	5	FAM179A	2	29255814	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	13497469	29255814	213943559	28	15555											
BIRC6	57448	broad.mit.edu	37	chr2	32613839	32613839	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggccacagttacatttcatCttcctcatcatgtgttgaag	9	14	8	10	0	4	1	3	1	1	0	5	1	5	1	2	1	1	2	2	1	2	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:32613839C>T	uc010ezu.2	+	4	801	c.667C>T	c.(667-669)CTT>TTT	p.L223F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	223					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TACATTTCATCTTCCTCATCA	0.368													14	41					0	0	0	0	T	32613839	T	T	32613839	3	4	78	1	0	0	0	0	1	0	0	0	1441	913	32	2	681	2	BIRC6	2	32613839	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	3358025	32613839	210585534	29	15556											
BIRC6	57448	broad.mit.edu	37	chr2	32726872	32726872	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gattatttaccatactgacaAcccttagtaaaaaagcttct	15	13	4	9	0	1	1	0	1	1	0	1	2	1	1	2	0	4	2	2	0	8	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:32726872A>G	uc010ezu.2	+	47	9258	c.9124A>G	c.(9124-9126)ACC>GCC	p.T3042A		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3042					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CATACTGACAACCCTTAGTAA	0.403													23	56					0	0	0	0	G	32726872	G	G	32726872	3	3	78	1	0	0	0	0	1	0	0	0	1441	43	2	5	9310	5	BIRC6	2	32726872	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	113033	32726872	210472501	30	15557											
FOXN2	3344	broad.mit.edu	37	chr2	48600434	48600434	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttttcccttttcagaatCtgatattgatgctgctgctg	7	18	7	9	0	2	3	1	2	1	1	3	3	3	3	1	0	3	3	1	0	2	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:48600434C>A	uc002rwh.1	+	6	1022	c.707C>A	c.(706-708)TCT>TAT	p.S236Y		NM_002158	NP_002149	P32314	FOXN2_HUMAN	T-cell leukemia virus enhancer factor	236					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			TTTTCAGAATCTGATATTGAT	0.289													24	55					5.61819e-17	7.51042e-17	1	0	A	48600434	A	A	48600434	3	1	78	1	0	0	0	0	1	0	0	0	6054	913	32	2	721	2	FOXN2	2	48600434	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	15873562	48600434	194598939	31	15558											
PNPT1	87178	broad.mit.edu	37	chr2	55894127	55894127	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctttttatataaattaccTgtgtttgtcctctttgaaat	10	20	5	6	0	1	1	0	1	1	0	2	1	2	1	2	0	2	2	2	0	6	8			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:55894127T>A	uc002rzf.2	-	13	1228	c.1175A>T	c.(1174-1176)CAG>CTG	p.Q392L	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	392					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ATAAATTACCTGTGTTTGTCC	0.318													11	24					0	0	0	0	A	55894127	A	A	55894127	3	1	78	1	0	0	0	0	1	0	0	0	12228	1594	55	5	1240	5	PNPT1	2	55894127	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	7293693	55894127	187305246	32	15559											
HK2	3099	broad.mit.edu	37	chr2	75107439	75107439	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggcggctggtgcccggctGcgatgtccgcttcctccgct	1	9	15	16	6	0	0	0	0	0	0	3	1	3	0	4	4	2	4	4	4	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:75107439G>T	uc002snd.2	+	10	3239	c.1313G>T	c.(1312-1314)TGC>TTC	p.C438F		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	438	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GTGCCCGGCTGCGATGTCCGC	0.627													77	242					1.04643e-32	1.53184e-32	1	0	T	75107439	T	T	75107439	3	4	78	1	0	0	0	0	1	0	0	0	7230	1319	46	4	1351	4	HK2	2	75107439	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	19213312	75107439	168091934	33	15560											
MFSD9	84804	broad.mit.edu	37	chr2	103335456	103335457	+	Frame_Shift_Ins	INS	-	A	A																															aaatatgtcccacatttcggINSaaaacagcaggttcttcatg																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:103335456_103335457insA	uc002tcb.2	-	6	915_916	c.847_848insT	c.(847-849)TCCfs	p.S283fs	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	283					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						CCACATTTCGGAAAACAGCAGG	0.574													---	---	---								A	103335457	A	A	103335456	7	5	78	1	0	1	1	0	0	0	0	0	9592	1174	41	0	580	0	MFSD9	2	103335456	Frame_Shift_Ins	INS	-	TCGA-CN-6021-01A-11D-1683-08	28228017	103335456	139863917	34	15561											
GLI2	2736	broad.mit.edu	37	chr2	121728127	121728127	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catggccctcacctccatcaAtgccacgcccacccagctca	9	6	5	21	1	3	0	3	0	0	0	4	0	4	0	6	1	2	1	6	1	1	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:121728127A>G	uc010flp.2	+	6	1034	c.1004A>G	c.(1003-1005)AAT>AGT	p.N335S	GLI2_uc002tmq.1_Missense_Mutation_p.N7S|GLI2_uc002tmr.1_Missense_Mutation_p.N7S|GLI2_uc002tmt.3_Missense_Mutation_p.N7S|GLI2_uc002tmu.3_Missense_Mutation_p.N7S|GLI2_uc002tmv.1_Silent_p.Q205Q|GLI2_uc010flo.1_Missense_Mutation_p.N210S|GLI2_uc002tmw.1_Missense_Mutation_p.N335S	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	335					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				ACCTCCATCAATGCCACGCCC	0.637													19	70					0	0	0	0	G	121728127	G	G	121728127	3	3	78	1	0	0	0	0	1	0	0	0	6475	101	4	5	1026	5	GLI2	2	121728127	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	18392671	121728127	121471246	35	15562											
THSD7B	80731	broad.mit.edu	37	chr2	137852677	137852677	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgttgaaggagaacttctGcagcaatgtcccaggtatta	12	12	10	7	0	1	2	0	1	1	1	2	3	2	2	1	2	3	4	1	2	5	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:137852677G>A	uc002tva.1	+	3	1092	c.1092G>A	c.(1090-1092)CTG>CTA	p.L364L	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Silent_p.L254L	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GAGAACTTCTGCAGCAATGTC	0.453													26	16					0	0	0	0	A	137852677	A	A	137852677	2	1	78	1	0	0	0	0	0	0	0	1	15946	1306	46	4		4	THSD7B	2	137852677	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	16124550	137852677	105346696	36	15563											
RIF1	55183	broad.mit.edu	37	chr2	152321320	152321320	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgtagagattagtgaaacAaaaaaggcagatgtgcaagc	18	6	12	5	1	0	3	0	1	0	2	0	5	0	3	0	1	3	3	0	1	7	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:152321320A>G	uc002txm.2	+	30	5416	c.5286A>G	c.(5284-5286)ACA>ACG	p.T1762T	RIF1_uc002txl.2_Silent_p.T1762T|RIF1_uc002txn.2_Silent_p.T1762T|RIF1_uc002txo.2_Silent_p.T1762T|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1762					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TTAGTGAAACAAAAAAGGCAG	0.368													20	57					0	0	0	0	G	152321320	G	G	152321320	2	3	78	1	0	0	0	0	0	0	0	1	13424	117	5	5		5	RIF1	2	152321320	Silent	SNP	A	TCGA-CN-6021-01A-11D-1683-08	14468643	152321320	90878053	37	15564											
SCN7A	6332	broad.mit.edu	37	chr2	167322306	167322306	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttacctcgaatataatatgGgtttccagttctgttgtgca	9	16	8	8	1	1	0	0	0	1	0	3	1	2	0	2	1	2	4	2	1	5	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:167322306G>C	uc002udu.1	-	7	983	c.856C>G	c.(856-858)CCA>GCA	p.P286A	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	286					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						ATATAATATGGGTTTCCAGTT	0.393													64	37					0	0	0	0	C	167322306	C	C	167322306	3	2	78	1	0	0	0	0	1	0	0	0	13988	1232	43	4	4268	4	SCN7A	2	167322306	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	15000986	167322306	75877067	38	15565											
TTN	7273	broad.mit.edu	37	chr2	179478783	179478783	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgattgagaaacttaccaaaCtgatatttggctgttattgg	12	15	9	5	0	0	3	0	3	0	1	0	4	0	3	1	2	3	2	1	2	5	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:179478783C>T	uc010zfg.1	-	211	41861	c.41637G>A	c.(41635-41637)CAG>CAA	p.Q13879Q	uc002ump.1_RNA|TTN_uc010zfh.1_Silent_p.Q7574Q|TTN_uc010zfi.1_Silent_p.Q7507Q|TTN_uc010zfj.1_Silent_p.Q7382Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14806							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTACCAAACTGATATTTGG	0.343													23	9					0	0	0	0	T	179478783	T	T	179478783	2	4	78	1	0	0	0	0	0	0	0	1	16803	564	20	4		4	TTN	2	179478783	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	12156477	179478783	63720590	39	15566											
TTN	7273	broad.mit.edu	37	chr2	179482708	179482708	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcaatgacgtagtttgtGatctcagcacctccatcata	12	13	6	10	1	3	2	3	2	1	0	5	2	4	2	2	0	1	3	2	0	4	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:179482708G>T	uc010zfg.1	-	202	39890	c.39666C>A	c.(39664-39666)ATC>ATA	p.I13222I	TTN_uc010zfh.1_Silent_p.I6917I|TTN_uc010zfi.1_Silent_p.I6850I|TTN_uc010zfj.1_Silent_p.I6725I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14149							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGTAGTTTGTGATCTCAGCAC	0.458													24	74					2.79863e-10	3.43144e-10	1	0	T	179482708	T	T	179482708	2	4	78	1	0	0	0	0	0	0	0	1	16803	1280	45	2		2	TTN	2	179482708	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	3925	179482708	63716665	40	15567											
TTN	7273	broad.mit.edu	37	chr2	179483562	179483562	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacaaggtcttggtcagctGtcttgatttttggtgcagct	6	15	11	9	0	3	1	1	1	2	0	3	1	3	1	1	3	3	3	1	3	1	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:179483562G>T	uc010zfg.1	-	200	39235	c.39011C>A	c.(39010-39012)ACA>AAA	p.T13004K	TTN_uc010zfh.1_Missense_Mutation_p.T6699K|TTN_uc010zfi.1_Missense_Mutation_p.T6632K|TTN_uc010zfj.1_Missense_Mutation_p.T6507K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13931							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGTCAGCTGTCTTGATTTT	0.403													26	11					1.26454e-06	1.40708e-06	1	0	T	179483562	T	T	179483562	3	4	78	1	0	0	0	0	1	0	0	0	16803	1377	48	4	61426	4	TTN	2	179483562	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	854	179483562	63715811	41	15568											
TTN	7273	broad.mit.edu	37	chr2	179494132	179494132	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttcccctgcagtcacggTgacatcctttaaaggcctca	8	12	8	13	1	2	1	2	1	0	0	4	1	4	1	4	2	1	2	4	2	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:179494132T>A	uc010zfg.1	-	189	36840	c.36616A>T	c.(36616-36618)ACC>TCC	p.T12206S	TTN_uc010zfh.1_Missense_Mutation_p.T5901S|TTN_uc010zfi.1_Missense_Mutation_p.T5834S|TTN_uc010zfj.1_Missense_Mutation_p.T5709S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13133							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAGTCACGGTGACATCCTTT	0.463													46	24					0	0	0	0	A	179494132	A	A	179494132	3	1	78	1	0	0	0	0	1	0	0	0	16803	1696	59	5	63865	5	TTN	2	179494132	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	10570	179494132	63705241	42	15569											
SSFA2	6744	broad.mit.edu	37	chr2	182784173	182784173	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccgctcctccgcactcatGgtacgctacctggagggtgg	5	10	12	14	3	1	0	1	0	0	0	4	1	4	1	4	4	2	4	4	4	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:182784173G>T	uc002uoi.2	+	14	3466	c.3144G>T	c.(3142-3144)ATG>ATT	p.M1048I	SSFA2_uc002uoh.2_Missense_Mutation_p.M1048I|SSFA2_uc002uoj.2_Missense_Mutation_p.M1048I|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.M895I|SSFA2_uc002uol.2_Missense_Mutation_p.M895I|SSFA2_uc002uom.2_Missense_Mutation_p.M516I	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	1048						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			CCGCACTCATGGTACGCTACC	0.507													56	114					1.13205e-32	1.6509e-32	1	0	T	182784173	T	T	182784173	3	4	78	1	0	0	0	0	1	0	0	0	15249	1362	47	4	3198	4	SSFA2	2	182784173	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	3290041	182784173	60415200	43	15570											
COL3A1	1281	broad.mit.edu	37	chr2	189864214	189864214	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggtgctgctggtcctcctGggccacctggtgctgctggt	2	11	16	12	0	0	0	0	0	0	0	2	0	2	0	4	5	4	4	4	5	0	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:189864214G>T	uc002uqj.1	+	31	2257	c.2140G>T	c.(2140-2142)GGG>TGG	p.G714W		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	714	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGGTCCTCCTGGGCCACCTGG	0.473													98	49					8.78727e-49	1.30119e-48	1	0	T	189864214	T	T	189864214	3	4	78	1	0	0	0	0	1	0	0	0	3703	1348	47	4	2262	4	COL3A1	2	189864214	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	7080041	189864214	53335159	44	15571											
MAP2	4133	broad.mit.edu	37	chr2	210574637	210574637	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtcttgcttgttaatacaGggtcagagccaattcgcaga	10	12	11	8	1	2	2	1	0	1	2	3	2	2	2	1	2	3	3	1	2	3	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:210574637G>T	uc002vde.1	+	12	4981	c.4733_splice	c.e12-1	p.R1578_splice	MAP2_uc002vdd.1_Splice_Site_p.R279_splice|MAP2_uc002vdf.1_Splice_Site_p.R222_splice|MAP2_uc002vdg.1_Splice_Site_p.R222_splice|MAP2_uc002vdh.1_Splice_Site_p.R279_splice|MAP2_uc002vdi.1_Splice_Site_p.R1574_splice	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1						central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TGTTAATACAGGGTCAGAGCC	0.458													13	21					2.27111e-07	2.57928e-07	1	0	T	210574637	T	T	210574637	5	4	78	1	0	0	0	0	0	0	1	0	9288	1014	35	4	4941	4	MAP2	2	210574637	Splice_Site	SNP	G	TCGA-CN-6021-01A-11D-1683-08	20710423	210574637	32624736	45	15572											
FN1	2335	broad.mit.edu	37	chr2	216235068	216235068	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccttatgcctctgctggtCtttcagtgcctccactatga	7	14	7	13	0	3	1	1	1	2	0	4	1	4	1	4	1	4	1	4	1	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr2:216235068C>T	uc002vfa.2	-	41	7068	c.6802G>A	c.(6802-6804)GAC>AAC	p.D2268N	FN1_uc002vfb.2_Missense_Mutation_p.D2056N|FN1_uc002vfc.2_Missense_Mutation_p.D2031N|FN1_uc002vfd.2_Missense_Mutation_p.D2212N|FN1_uc002vfe.2_Missense_Mutation_p.D2146N|FN1_uc002vff.2_Missense_Mutation_p.D2121N|FN1_uc002vfg.2_Missense_Mutation_p.D2087N|FN1_uc002vfh.2_Missense_Mutation_p.D1967N|FN1_uc002vfi.2_Missense_Mutation_p.D2237N|FN1_uc002vfj.2_Missense_Mutation_p.D2058N|FN1_uc002vez.2_Missense_Mutation_p.D431N|FN1_uc010zjp.1_Missense_Mutation_p.D805N|FN1_uc002vfk.1_RNA|FN1_uc010fva.1_Intron|FN1_uc010fvb.1_Intron|FN1_uc010fvc.1_Missense_Mutation_p.D510N|FN1_uc010fvd.1_Missense_Mutation_p.D328N	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	2177	Fibronectin type-III 16.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCTGCTGGTCTTTCAGTGCC	0.522													5	29					0	0	0	0	T	216235068	T	T	216235068	3	4	78	1	0	0	0	0	1	0	0	0	5994	913	32	2	655	2	FN1	2	216235068	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	5660431	216235068	26964305	46	15573											
CNTN6	27255	broad.mit.edu	37	chr3	1414594	1414594	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatatctctgcacagtacaaAcaaccctagaaagtttatct	16	11	4	10	0	2	1	0	0	2	1	3	1	2	1	1	0	4	3	1	0	8	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:1414594A>G	uc003boz.2	+	14	2008	c.1741A>G	c.(1741-1743)ACA>GCA	p.T581A	CNTN6_uc011asj.1_Missense_Mutation_p.T509A|CNTN6_uc003bpa.2_Missense_Mutation_p.T581A	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	581	Ig-like C2-type 6.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CACAGTACAAACAACCCTAGA	0.368													34	50					0	0	0	0	G	1414594	G	G	1414594	3	3	78	1	0	0	0	0	1	0	0	0	3660	43	2	5	1791	5	CNTN6	3	1414594	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08		1414594	196607836	47	15574											
CNTN4	152330	broad.mit.edu	37	chr3	3080618	3080618	+	Frame_Shift_Del	DEL	C	-	-																															tttttgtctccttgtgcagtCcccgaagtcacaccagcgaa																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:3080618delC	uc003bpc.2	+	18	2315	c.2094delC	c.(2092-2094)CTCfs	p.L698fs	CNTN4_uc003bpb.1_Frame_Shift_Del_p.L369fs|CNTN4_uc003bpe.2_Frame_Shift_Del_p.L370fs|CNTN4_uc003bpf.2_Frame_Shift_Del_p.L369fs|CNTN4_uc003bpg.2_5'Flank	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	698					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CTTGTGCAGTCCCCGAAGTCA	0.498													---	---	---								-	3080618	-	-	3080618	7	5	78	1	0	1	0	1	0	0	0	0	3658	869	30	0	2156	0	CNTN4	3	3080618	Frame_Shift_Del	DEL	C	TCGA-CN-6021-01A-11D-1683-08	1666024	3080618	194941812	48	15575											
FANCD2	2177	broad.mit.edu	37	chr3	10083359	10083359	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaatcctggatgtccttTcaagcctccgacttgaccca	8	11	6	16	1	1	1	1	1	0	0	5	3	5	2	6	1	1	0	6	1	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:10083359T>A	uc003buw.2	+	10	826	c.748T>A	c.(748-750)TCA>ACA	p.S250T	FANCD2_uc003bux.1_Missense_Mutation_p.S250T|FANCD2_uc003buy.1_Missense_Mutation_p.S250T	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	250	Interaction with FANCE.|Interaction with BRCA2.				DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GGATGTCCTTTCAAGCCTCCG	0.428			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				34	36					0	0	0	0	A	10083359	A	A	10083359	3	1	78	1	0	0	0	0	1	0	0	0	5697	1783	62	5	782	5	FANCD2	3	10083359	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	7002741	10083359	187939071	49	15576											
CHCHD4	131474	broad.mit.edu	37	chr3	14154580	14154580	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaccccttgatctcctccGtgctatagtggaagcaggaa	9	10	10	12	1	1	2	0	2	1	0	3	4	2	4	4	2	2	2	4	2	4	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:14154580G>A	uc003byj.3	-	3	431	c.236C>T	c.(235-237)ACG>ATG	p.T79M	CHCHD4_uc003byi.3_Missense_Mutation_p.T92M	NM_001098502	NP_001091972	Q8N4Q1	MIA40_HUMAN	coiled-coil-helix-coiled-coil-helix domain	79	CHCH.				protein transport|transmembrane transport	mitochondrial intermembrane space					0						GATCTCCTCCGTGCTATAGTG	0.483													22	17					0	0	0	0	A	14154580	A	A	14154580	3	1	78	1	0	0	0	0	1	0	0	0	3333	1145	40	1	196	1	CHCHD4	3	14154580	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	4071221	14154580	183867850	50	15577											
AMIGO3	386724	broad.mit.edu	37	chr3	49755899	49755899	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctatggccaagctgccgtCggccagcaccgcgatgctgc	6	6	13	16	4	0	0	0	0	0	0	1	1	0	0	5	2	5	3	5	2	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:49755899C>T	uc003cxj.2	-	1	1340	c.1000G>A	c.(1000-1002)GAC>AAC	p.D334N	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	334	Extracellular (Potential).|Ig-like C2-type.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AAGCTGCCGTCGGCCAGCACC	0.667													8	31					0	0	0	0	T	49755899	T	T	49755899	3	4	78	1	0	0	0	0	1	0	0	0	577	884	31	1	518	1	AMIGO3	3	49755899	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	35601319	49755899	148266531	51	15578											
OR5K4	403278	broad.mit.edu	37	chr3	98073045	98073045	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagactgctttcttctggcGacaatggcctatgaccgcta	9	11	9	12	2	2	2	0	1	2	1	2	3	2	2	2	2	1	2	2	2	3	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:98073045G>T	uc011bgv.1	+	1	348	c.348G>T	c.(346-348)GCG>GCT	p.A116A		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TTCTTCTGGCGACAATGGCCT	0.458													177	140					1.29928e-97	1.93885e-97	1	0	T	98073045	T	T	98073045	2	4	78	1	0	0	0	0	0	0	0	1	11223	1045	37	3		3	OR5K4	3	98073045	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	48317146	98073045	99949385	52	15579											
DPPA4	55211	broad.mit.edu	37	chr3	109050598	109050598	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccttttgatttgggtaggCaaaggcacacaggcgcttat	10	12	11	8	1	0	1	0	1	0	0	0	1	0	1	1	4	1	4	1	4	4	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:109050598C>A	uc003dxq.3	-	4	428	c.373G>T	c.(373-375)GCC>TCC	p.A125S	DPPA4_uc011bho.1_Missense_Mutation_p.A125S|DPPA4_uc011bhp.1_Missense_Mutation_p.A125S	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	125						nucleus	protein binding			upper_aerodigestive_tract(1)	1						TTTGGGTAGGCAAAGGCACAC	0.403													15	132					5.3912e-06	5.93032e-06	1	0	A	109050598	A	A	109050598	3	1	78	1	0	0	0	0	1	0	0	0	4758	710	25	4	557	4	DPPA4	3	109050598	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	10977553	109050598	88971832	53	15580											
SEMA5B	54437	broad.mit.edu	37	chr3	122646688	122646688	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgaagcggtggcccactgcCcaggctgcggtagatggcag	7	5	17	12	3	0	1	0	0	0	1	0	2	0	1	2	5	3	3	2	5	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:122646688C>T	uc003efz.1	-	8	1103	c.799G>A	c.(799-801)GGC>AGC	p.G267S	SEMA5B_uc011bju.1_Missense_Mutation_p.G209S|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.G267S|SEMA5B_uc010hro.1_Missense_Mutation_p.G209S|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	267	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		GGCCCACTGCCCAGGCTGCGG	0.617													51	45					0	0	0	0	T	122646688	T	T	122646688	3	4	78	1	0	0	0	0	1	0	0	0	14103	623	22	4	2720	4	SEMA5B	3	122646688	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	13596090	122646688	75375742	54	15581											
MYLK	4638	broad.mit.edu	37	chr3	123451900	123451900	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgccttcctgtctcctcacGggggtgccttccaggaacca	5	10	10	16	1	2	0	1	0	1	0	5	1	4	1	6	3	3	0	6	3	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:123451900G>T	uc003ego.2	-	11	1641	c.1359C>A	c.(1357-1359)CCC>CCA	p.P453P	MYLK_uc011bjw.1_Silent_p.P453P|MYLK_uc003egp.2_Intron|MYLK_uc003egq.2_Silent_p.P453P|MYLK_uc003egr.2_Intron|MYLK_uc003egs.2_Silent_p.P277P	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	453	Ig-like C2-type 3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GTCTCCTCACGGGGGTGCCTT	0.572													25	28					3.73808e-20	5.13986e-20	1	0	T	123451900	T	T	123451900	2	4	78	1	0	0	0	0	0	0	0	1	10109	1103	39	3		3	MYLK	3	123451900	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	805212	123451900	74570530	55	15582											
ITGB5	3693	broad.mit.edu	37	chr3	124538590	124538590	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctccctcccagcataccttgTacagcatataatggtttttt	9	15	5	12	0	0	0	0	0	0	0	2	0	2	0	3	1	4	4	3	1	4	8			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:124538590T>C	uc003eho.2	-	7	1331	c.1034A>G	c.(1033-1035)TAC>TGC	p.Y345C	ITGB5_uc010hrx.2_5'Flank	NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	345	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)		GCATACCTTGTACAGCATATA	0.483													21	95					0	0	0	0	C	124538590	C	C	124538590	3	2	78	1	0	0	0	0	1	0	0	0	7937	1638	57	5	1401	5	ITGB5	3	124538590	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	1086690	124538590	73483840	56	15583											
RAB43	339122	broad.mit.edu	37	chr3	128849001	128849001	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atacttctggaggagttccaTtttcttccttcgcaccagtg	7	15	8	11	1	2	0	0	0	2	0	5	2	4	2	3	2	1	2	3	2	1	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:128849001T>C	uc003elo.1	-	11	992	c.781A>G	c.(781-783)ATG>GTG	p.M261V	ISY1_uc010hsz.1_Missense_Mutation_p.M81V|ISY1_uc003elp.1_Missense_Mutation_p.M261V|ISY1_uc010hta.1_Missense_Mutation_p.M283V	NM_020701	NP_065752	Q86YS6	RAB43_HUMAN	ISY1 splicing factor homolog	Error:Variant_position_missing_in_Q86YS6_after_alignment					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			lung(1)	1						AGGAGTTCCATTTTCTTCCTT	0.567													26	104					0	0	0	0	C	128849001	C	C	128849001	3	2	78	1	0	0	0	0	1	0	0	0	13010	1493	52	5		5	RAB43	3	128849001	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	4310411	128849001	69173429	57	15584											
COL6A6	131873	broad.mit.edu	37	chr3	130327809	130327809	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgggacttaagggccctcagGtacatatcaagaccaatcag	13	8	10	10	0	3	1	3	0	0	1	3	2	3	2	2	3	1	1	2	3	5	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:130327809G>T	uc010htl.2	+	21	4783	c.4752_splice	c.e21+1	p.Q1584_splice	COL6A6_uc003eni.3_Splice_Site	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor						axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GGGCCCTCAGGTACATATCAA	0.463													9	50					1.12685e-05	1.229e-05	1	0	T	130327809	T	T	130327809	5	4	78	1	0	0	0	0	0	0	1	0	3718	1275	44	4	4835	4	COL6A6	3	130327809	Splice_Site	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1478808	130327809	67694621	58	15585											
PRR23B	389151	broad.mit.edu	37	chr3	138739052	138739052	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctcgtaggcctcttccTgggcggcgatctctgggaca	4	10	12	15	3	2	0	0	0	2	0	6	2	4	1	4	4	0	1	4	4	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:138739052T>A	uc003esy.1	-	1	717	c.452A>T	c.(451-453)CAG>CTG	p.Q151L		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	151										breast(1)	1						GGCCTCTTCCTGGGCGGCGAT	0.652													19	110					0	0	0	0	A	138739052	A	A	138739052	3	1	78	1	0	0	0	0	1	0	0	0	12657	1580	55	5	349	5	PRR23B	3	138739052	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	8411243	138739052	59283378	59	15586											
SR140	23350	broad.mit.edu	37	chr3	142742816	142742816	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgatgtgacttcatatacaGactctgtcgcaagccatagt	11	12	8	10	1	2	3	1	2	1	1	3	3	2	3	1	0	2	1	1	0	4	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:142742816G>A	uc003evh.1	+	13	1330	c.1231_splice	c.e13-1	p.T411_splice	SR140_uc003evi.1_Intron|SR140_uc003evj.1_Splice_Site|SR140_uc003evk.1_Splice_Site_p.T410_splice|SR140_uc003evl.1_5'Flank	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein						RNA processing	nucleus	nucleotide binding|RNA binding				0						TTCATATACAGACTCTGTCGC	0.303													7	64					0	0	0	0	A	142742816	A	A	142742816	5	1	78	1	0	0	0	0	0	0	1	0	15197	956	33	2	1280	2	SR140	3	142742816	Splice_Site	SNP	G	TCGA-CN-6021-01A-11D-1683-08	4003764	142742816	55279614	60	15587											
CHST2	9435	broad.mit.edu	37	chr3	142840860	142840860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatggaggtcatctgcaataGtatggctaagacgctgcaga	12	10	12	7	1	2	2	1	0	1	2	2	3	2	3	0	3	2	5	0	3	5	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:142840860G>A	uc003evm.2	+	2	2091	c.1202G>A	c.(1201-1203)AGT>AAT	p.S401N		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	401	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						ATCTGCAATAGTATGGCTAAG	0.652													23	129					0	0	0	0	A	142840860	A	A	142840860	3	1	78	1	0	0	0	0	1	0	0	0	3419	1029	36	4	1204	4	CHST2	3	142840860	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	98044	142840860	55181570	61	15588											
MED12L	116931	broad.mit.edu	37	chr3	151082978	151082978	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgaatgtatgtatgggcCatcaggatgctggcaggtga	10	11	14	6	0	2	2	2	2	0	0	2	3	2	3	1	4	1	4	1	4	3	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:151082978C>T	uc003eyp.2	+	20	3102	c.3064C>T	c.(3064-3066)CAT>TAT	p.H1022Y	MED12L_uc011bnz.1_Missense_Mutation_p.H882Y|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.H185Y	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1022					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATGTATGGGCCATCAGGATGC	0.463													79	126					0	0	0	0	T	151082978	T	T	151082978	3	4	78	1	0	0	0	0	1	0	0	0	9482	594	21	4	3142	4	MED12L	3	151082978	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	8242118	151082978	46939452	62	15589											
GOLIM4	27333	broad.mit.edu	37	chr3	167742786	167742786	+	Frame_Shift_Del	DEL	G	-	-																															tttgctcttcattttcatctGgcaaattttcttctctcact																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:167742786delG	uc003ffe.2	-	13	2065	c.1721delC	c.(1720-1722)CCAfs	p.P574fs	GOLIM4_uc011bpe.1_Frame_Shift_Del_p.P575fs|GOLIM4_uc011bpf.1_Frame_Shift_Del_p.P547fs|GOLIM4_uc011bpg.1_Frame_Shift_Del_p.P546fs	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	574	Glu-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						ATTTTCATCTGGCAAATTTTC	0.418													---	---	---								-	167742786	-	-	167742786	7	5	78	1	0	1	0	1	0	0	0	0	6603	1348	47	0	385	0	GOLIM4	3	167742786	Frame_Shift_Del	DEL	G	TCGA-CN-6021-01A-11D-1683-08	16659808	167742786	30279644	63	15590											
MECOM	2122	broad.mit.edu	37	chr3	169099256	169099256	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtgctggctactccatctgCatctggcatttcttccaaag	8	13	8	12	0	3	0	0	0	3	0	5	0	5	0	2	2	3	4	2	2	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:169099256C>A	uc011bpj.1	-	2	497	c.94G>T	c.(94-96)GCA>TCA	p.A32S	MECOM_uc003ffl.2_Missense_Mutation_p.A4S|MECOM_uc011bpk.1_Intron|MECOM_uc010hwn.2_Missense_Mutation_p.A32S|MECOM_uc011bpl.1_Missense_Mutation_p.A32S	NM_004991	NP_004982	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform c	Error:Variant_position_missing_in_Q03112_after_alignment					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						ACTCCATCTGCATCTGGCATT	0.428													5	64					1.23904e-05	1.34375e-05	1	0	A	169099256	A	A	169099256	3	1	78	1	0	0	0	0	1	0	0	0	9475	710	25	4	3699	4	MECOM	3	169099256	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	1356470	169099256	28923174	64	15591											
SAMD7	344658	broad.mit.edu	37	chr3	169639092	169639092	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgttctaccaaacacaaaTatggcaaatgtgttgtccag	13	12	7	9	0	2	0	0	0	2	0	3	0	3	0	2	1	2	3	2	1	5	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:169639092T>C	uc003fgd.2	+	4	444	c.177T>C	c.(175-177)AAT>AAC	p.N59N	SAMD7_uc003fge.2_Silent_p.N59N|SAMD7_uc011bpo.1_5'UTR	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	59										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			CAAACACAAATATGGCAAATG	0.438													29	124					0	0	0	0	C	169639092	C	C	169639092	2	2	78	1	0	0	0	0	0	0	0	1	13889	1403	49	5		5	SAMD7	3	169639092	Silent	SNP	T	TCGA-CN-6021-01A-11D-1683-08	539836	169639092	28383338	65	15592											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			29	27					0	0	0	0	A	178936082	A	A	178936082	3	1	78	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	9296990	178936082	19086348	66	15593											
KCNMB3	27094	broad.mit.edu	37	chr3	178984452	178984452	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacctcccctggcgcctcCggctgccctgaagtgtgatt	4	11	10	16	2	0	2	0	2	0	0	2	2	2	2	6	2	2	1	6	2	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:178984452C>A	uc003fjp.1	-	1	387	c.47G>T	c.(46-48)CGG>CTG	p.R16L	KCNMB3_uc011bqc.1_Missense_Mutation_p.R16L	NM_171828	NP_741979	Q9NPA1	KCMB3_HUMAN	calcium-activated potassium channel beta 3	Error:Variant_position_missing_in_Q9NPA1_after_alignment					detection of calcium ion|platelet activation|regulation of action potential in neuron	voltage-gated potassium channel complex	calcium-activated potassium channel activity|potassium channel regulator activity				0	all_cancers(143;5.6e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;2.41e-27)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.03)			CTGGCGCCTCCGGCTGCCCTG	0.597													24	31					2.89027e-11	3.60114e-11	1	0	A	178984452	A	A	178984452	3	1	78	1	0	0	0	0	1	0	0	0	8115	652	23	3	1009	3	KCNMB3	3	178984452	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	48370	178984452	19037978	67	15594											
ATP13A4	84239	broad.mit.edu	37	chr3	193153532	193153532	+	Frame_Shift_Del	DEL	C	-	-																															aacgagagctgcacgtccttCcctgtgtaagaaaagaaatg																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr3:193153532delC	uc003ftd.2	-	24	2782	c.2674delG	c.(2674-2676)GAAfs	p.E892fs	ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	892	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GCACGTCCTTCCCTGTGTAAG	0.403													---	---	---								-	193153532	-	-	193153532	7	5	78	1	0	1	0	1	0	0	0	0	1128	869	30	0	944	0	ATP13A4	3	193153532	Frame_Shift_Del	DEL	C	TCGA-CN-6021-01A-11D-1683-08	14169080	193153532	4868898	68	15595											
EPHA5	2044	broad.mit.edu	37	chr4	66230769	66230769	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccttctaaatggatgatgttAggatgatcaaactgtcccat	12	13	8	8	0	2	2	1	2	1	0	3	4	3	4	2	2	1	1	2	2	4	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:66230769A>G	uc003hcy.2	-	12	2395	c.2202T>C	c.(2200-2202)CCT>CCC	p.P734P	EPHA5_uc003hcx.2_Silent_p.P666P|EPHA5_uc003hcz.2_Silent_p.P712P|EPHA5_uc011cah.1_Silent_p.P735P|EPHA5_uc011cai.1_Silent_p.P713P|EPHA5_uc003hda.2_Silent_p.P735P	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	734	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GGATGATGTTAGGATGATCAA	0.363										TSP Lung(17;0.13)			34	45					0	0	0	0	G	66230769	G	G	66230769	2	3	78	1	0	0	0	0	0	0	0	1	5194	407	15	5		5	EPHA5	4	66230769	Silent	SNP	A	TCGA-CN-6021-01A-11D-1683-08		66230769	124923507	69	15596											
PDHA2	5161	broad.mit.edu	37	chr4	96761669	96761669	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagggctcatggtgtgtgctAtactcggggactttctgtcc	5	14	13	9	1	2	0	1	0	1	0	4	1	3	1	1	4	2	2	1	4	3	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:96761669A>G	uc003htr.3	+	1	431	c.368A>G	c.(367-369)TAT>TGT	p.Y123C		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	123					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GGTGTGTGCTATACTCGGGGA	0.522													13	39					0	0	0	0	G	96761669	G	G	96761669	3	3	78	1	0	0	0	0	1	0	0	0	11719	449	16	5	370	5	PDHA2	4	96761669	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	30530900	96761669	94392607	70	15597											
CENPE	1062	broad.mit.edu	37	chr4	104060953	104060953	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actctgaactcactctagctAtcatttcccttaaggttgct	9	15	5	12	0	4	1	2	1	2	0	5	1	5	1	1	1	3	3	1	1	4	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:104060953A>T	uc003hxb.1	-	38	6287	c.6197T>A	c.(6196-6198)ATA>AAA	p.I2066K	CENPE_uc003hxc.1_Intron|CENPE_uc003hxd.1_Intron	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	2066	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CACTCTAGCTATCATTTCCCT	0.313													25	29					0	0	0	0	T	104060953	T	T	104060953	3	4	78	1	0	0	0	0	1	0	0	0	3245	449	16	5	1956	5	CENPE	4	104060953	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	7299284	104060953	87093323	71	15598											
CENPE	1062	broad.mit.edu	37	chr4	104079563	104079563	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtattaattgtttcttgaTgttgtttcagagactcaaga	10	18	9	4	0	3	3	2	1	1	2	3	4	3	3	0	0	0	4	0	0	3	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:104079563T>A	uc003hxb.1	-	24	3017	c.2927A>T	c.(2926-2928)CAT>CTT	p.H976L	CENPE_uc003hxc.1_Missense_Mutation_p.H951L	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	976	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TGTTTCTTGATGTTGTTTCAG	0.284													8	3					0	0	0	0	A	104079563	A	A	104079563	3	1	78	1	0	0	0	0	1	0	0	0	3245	1464	51	5	5282	5	CENPE	4	104079563	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	18610	104079563	87074713	72	15599											
TACR3	6870	broad.mit.edu	37	chr4	104579544	104579544	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtctgggtttcaagggatCaataatagccatatacctat	13	12	8	8	0	3	0	2	0	1	0	3	1	3	1	2	2	2	1	2	2	7	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:104579544C>T	uc003hxe.1	-	2	708	c.565G>A	c.(565-567)GAT>AAT	p.D189N		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	189	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TTCAAGGGATCAATAATAGCC	0.353													6	23					0	0	0	0	T	104579544	T	T	104579544	3	4	78	1	0	0	0	0	1	0	0	0	15573	826	29	2	848	2	TACR3	4	104579544	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	499981	104579544	86574732	73	15600											
AGXT2L1	64850	broad.mit.edu	37	chr4	109681049	109681049	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcagctttgaccactcctGggtgacagtgtcccactaaa	9	9	11	12	0	0	2	0	2	0	0	2	2	2	2	3	2	1	2	3	2	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:109681049G>T	uc003hzc.2	-	3	372	c.191C>A	c.(190-192)CCA>CAA	p.P64Q	AGXT2L1_uc010imc.2_Intron|AGXT2L1_uc011cfm.1_Missense_Mutation_p.P24Q|AGXT2L1_uc011cfn.1_5'UTR|AGXT2L1_uc011cfo.1_Missense_Mutation_p.P6Q	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	64					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		GACCACTCCTGGGTGACAGTG	0.383													10	19					9.05144e-12	1.13883e-11	1	0	T	109681049	T	T	109681049	3	4	78	1	0	0	0	0	1	0	0	0	406	1348	47	4	1352	4	AGXT2L1	4	109681049	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	5101505	109681049	81473227	74	15601											
ANK2	287	broad.mit.edu	37	chr4	114278600	114278601	+	Frame_Shift_Ins	INS	-	A	A																															ttttctctagtgaagaaagcINSaaaacccaaacagatgcaaa																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:114278600_114278601insA	uc003ibe.3	+	38	8926_8927	c.8826_8827insA	c.(8824-8829)AGCAAAfs	p.S2942fs	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Frame_Shift_Ins_p.S244fs|ANK2_uc011cgb.1_Frame_Shift_Ins_p.S2957fs	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2909_2910					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GTGAAGAAAGCAAAACCCAAAC	0.416													---	---	---								A	114278601	A	A	114278600	7	5	78	1	0	1	1	0	0	0	0	0	621	709	25	0	9041	0	ANK2	4	114278600	Frame_Shift_Ins	INS	-	TCGA-CN-6021-01A-11D-1683-08	4597551	114278600	76875676	75	15602											
PRDM5	11107	broad.mit.edu	37	chr4	121631548	121631548	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaggccttgctgcactcTgagcacttgtacggcttctc	6	12	10	13	1	2	2	0	2	2	0	3	2	2	2	1	2	4	5	1	2	2	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:121631548T>A	uc003idn.2	-	15	1894	c.1644A>T	c.(1642-1644)TCA>TCT	p.S548S	PRDM5_uc003ido.2_Silent_p.S517S|PRDM5_uc010ine.2_Nonsense_Mutation_p.R489*	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	548	C2H2-type 14.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						TGCTGCACTCTGAGCACTTGT	0.458													9	21					0	0	0	0	A	121631548	A	A	121631548	2	1	78	1	0	0	0	0	0	0	0	1	12522	1567	55	5		5	PRDM5	4	121631548	Silent	SNP	T	TCGA-CN-6021-01A-11D-1683-08	7352948	121631548	69522728	76	15603											
KIAA1109	84162	broad.mit.edu	37	chr4	123107289	123107289	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacgccttcaagagttgtttGgtttggagccaacaataatt	11	13	10	7	1	1	1	1	0	0	1	1	3	1	2	2	2	2	3	2	2	4	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:123107289G>T	uc003ieh.2	+	5	502	c.457G>T	c.(457-459)GGT>TGT	p.G153C	KIAA1109_uc003iei.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	153					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGAGTTGTTTGGTTTGGAGCC	0.378													16	26					3.41278e-10	4.17118e-10	1	0	T	123107289	T	T	123107289	3	4	78	1	0	0	0	0	1	0	0	0	8247	1348	47	4	475	4	KIAA1109	4	123107289	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1475741	123107289	68046987	77	15604											
SPOCK3	50859	broad.mit.edu	37	chr4	167656083	167656083	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtcatcaatcaaatgtataCatcatggtcatcaccaccat	14	12	4	11	0	6	0	6	0	0	0	6	0	6	0	2	1	1	1	2	1	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:167656083C>T	uc003iri.1	-	12	1441	c.1300G>A	c.(1300-1302)GTA>ATA	p.V434I	SPOCK3_uc011cjp.1_Missense_Mutation_p.V391I|SPOCK3_uc011cjq.1_Missense_Mutation_p.V443I|SPOCK3_uc011cjr.1_Missense_Mutation_p.V314I|SPOCK3_uc003irj.1_Missense_Mutation_p.V431I|SPOCK3_uc011cjs.1_Missense_Mutation_p.V383I|SPOCK3_uc011cjt.1_Missense_Mutation_p.V342I|SPOCK3_uc011cju.1_Missense_Mutation_p.V327I|SPOCK3_uc011cjv.1_Missense_Mutation_p.V336I	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	434	Asp-rich.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		caaatgtatacatcatggtca	0.08													20	23					0	0	0	0	T	167656083	T	T	167656083	3	4	78	1	0	0	0	0	1	0	0	0	15147	478	17	4	14	4	SPOCK3	4	167656083	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	44548794	167656083	23498193	78	15605											
SH3RF1	57630	broad.mit.edu	37	chr4	170017675	170017675	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgtcagtctcctcataTgttttccacaaagcttcctg	8	15	6	12	0	4	0	3	0	1	0	7	0	6	0	3	0	1	2	3	0	2	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr4:170017675T>C	uc003isa.1	-	12	2997	c.2662A>G	c.(2662-2664)ATA>GTA	p.I888V		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	888	SH3 4.					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TCTCCTCATATGTTTTCCACA	0.403													31	47					0	0	0	0	C	170017675	C	C	170017675	3	2	78	1	0	0	0	0	1	0	0	0	14323	1464	51	5	8	5	SH3RF1	4	170017675	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	2361592	170017675	21136601	79	15606											
EXOC3	11336	broad.mit.edu	37	chr5	466943	466943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagggcccagcacaggccaGccccagctacgtgcccctct	7	4	11	19	1	1	0	0	0	1	0	1	0	1	0	6	2	5	3	6	2	1	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:466943G>A	uc003jba.2	+	13	2296	c.2168G>A	c.(2167-2169)AGC>AAC	p.S723N	uc003jbb.1_5'Flank	NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	734					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GCACAGGCCAGCCCCAGCTAC	0.662													4	17					0	0	0	0	A	466943	A	A	466943	3	1	78	1	0	0	0	0	1	0	0	0	5327	971	34	4	2214	4	EXOC3	5	466943	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08		466943	180448317	80	15607											
SEMA5A	9037	broad.mit.edu	37	chr5	9154604	9154604	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggagatgccctacctgcGtgtgcggtagaactggcacc	7	7	13	14	3	0	2	0	0	0	2	0	3	0	2	4	3	5	2	4	3	3	2	rs149803731		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:9154604G>A	uc003jek.2	-	12	2189	c.1477C>T	c.(1477-1479)CGC>TGC	p.R493C		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	493	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CCCTACCTGCGTGTGCGGTAG	0.617													19	39					0	0	0	0	A	9154604	A	A	9154604	3	1	78	1	0	0	0	0	1	0	0	0	14102	1145	40	1	1795	1	SEMA5A	5	9154604	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	8687661	9154604	171760656	81	15608											
CTNND2	1501	broad.mit.edu	37	chr5	11346593	11346593	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcaacagagggacaatactGcagctgtcggtaggggtccg	10	7	14	10	2	1	1	1	0	0	1	3	2	2	2	1	4	4	3	1	4	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:11346593G>A	uc003jfa.1	-	9	1664	c.1519C>T	c.(1519-1521)CAG>TAG	p.Q507*	CTNND2_uc010itt.2_Nonsense_Mutation_p.Q416*|CTNND2_uc011cmy.1_Nonsense_Mutation_p.Q170*|CTNND2_uc011cmz.1_Nonsense_Mutation_p.Q74*|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Nonsense_Mutation_p.Q74*	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	507					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GGACAATACTGCAGCTGTCGG	0.627													23	86					0	0	0	0	A	11346593	A	A	11346593	4	1	78	1	0	0	0	0	0	1	0	0	4037	1328	46	4	2214	4	CTNND2	5	11346593	Nonsense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2191989	11346593	169568667	82	15609											
DNAH5	1767	broad.mit.edu	37	chr5	13721172	13721172	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccctggcccatggacacAtaacgggtttctatttttaa	9	13	9	10	1	1	0	0	0	1	0	1	1	1	1	2	4	1	1	2	4	3	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:13721172A>T	uc003jfd.2	-	71	12258	c.12216T>A	c.(12214-12216)TAT>TAA	p.Y4072*	DNAH5_uc003jfc.2_Nonsense_Mutation_p.Y240*	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4072	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCATGGACACATAACGGGTTT	0.517									Kartagener_syndrome				25	62					0	0	0	0	T	13721172	T	T	13721172	4	4	78	1	0	0	0	0	0	1	0	0	4626	224	8	5	1694	5	DNAH5	5	13721172	Nonsense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	2374579	13721172	167194088	83	15610											
DNAH5	1767	broad.mit.edu	37	chr5	13845071	13845071	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgagacgaagaaaaaccGaggaaagcacagtcgttttt	16	8	10	7	3	1	2	0	1	1	2	2	6	1	3	1	1	2	2	1	1	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:13845071G>T	uc003jfd.2	-	32	5188	c.5146C>A	c.(5146-5148)CGG>AGG	p.R1716R		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1716	Stem (By similarity).		R -> L (in CILD3).		microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAGAAAAACCGAGGAAAGCAC	0.443									Kartagener_syndrome				17	50					1.67942e-08	1.9534e-08	1	0	T	13845071	T	T	13845071	2	4	78	1	0	0	0	0	0	0	0	1	4626	1057	37	3		3	DNAH5	5	13845071	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	123899	13845071	167070189	84	15611											
PRDM9	56979	broad.mit.edu	37	chr5	23510090	23510090	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggccatcaaactccaggtGgatgacacagaagattctga	14	7	10	10	0	2	4	1	2	1	2	3	5	3	5	2	3	1	0	2	3	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:23510090G>T	uc003jgo.2	+	4	437	c.255G>T	c.(253-255)GTG>GTT	p.V85V		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	85	KRAB-related.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AACTCCAGGTGGATGACACAG	0.398										HNSCC(3;0.000094)			15	35					0.000566183	0.000587549	1	0	T	23510090	T	T	23510090	2	4	78	1	0	0	0	0	0	0	0	1	12525	1335	47	4		4	PRDM9	5	23510090	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	9665019	23510090	157405170	85	15612											
CARD6	84674	broad.mit.edu	37	chr5	40853726	40853726	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtcagagcagaggcctaaGtggttccatcctttgccttt	7	12	12	10	0	1	2	1	0	0	2	3	2	3	2	4	3	2	2	4	3	1	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:40853726G>A	uc003jmg.2	+	3	2367	c.2292G>A	c.(2290-2292)AAG>AAA	p.K764K		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	764					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						AGAGGCCTAAGTGGTTCCATC	0.488													60	128					0	0	0	0	A	40853726	A	A	40853726	2	1	78	1	0	0	0	0	0	0	0	1	2662	1020	36	4		4	CARD6	5	40853726	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	17343636	40853726	140061534	86	15613											
ELOVL7	79993	broad.mit.edu	37	chr5	60067895	60067895	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtggcagaggcgaggacatGaggagccaatcttcaactct	11	8	13	9	1	3	2	1	1	2	1	3	5	3	4	1	4	2	1	1	4	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:60067895G>A	uc003jsi.3	-	4	290	c.90C>T	c.(88-90)CTC>CTT	p.L30L	ELOVL7_uc011cqo.1_5'UTR|ELOVL7_uc010iwk.2_Silent_p.L30L|ELOVL7_uc003jsj.3_Silent_p.L17L	NM_024930	NP_079206	A1L3X0	ELOV7_HUMAN	elongation of very long chain fatty acids-like	30	Helical; (Potential).				fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				GCGAGGACATGAGGAGCCAAT	0.438													6	24					0	0	0	0	A	60067895	A	A	60067895	2	1	78	1	0	0	0	0	0	0	0	1	5103	1277	45	2		2	ELOVL7	5	60067895	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	19214169	60067895	120847365	87	15614											
CHD1	1105	broad.mit.edu	37	chr5	98193970	98193970	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttttcctggaatcacttttTttgtaagaatctccctgatg	8	18	6	9	0	2	2	1	1	1	1	4	3	3	3	2	1	0	1	2	1	3	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:98193970T>A	uc003knf.2	-	34	4849	c.4701A>T	c.(4699-4701)AAA>AAT	p.K1567N	CHD1_uc010jbn.2_Missense_Mutation_p.K293N	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1567					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	AATCACTTTTTTTGTAAGAAT	0.403													60	76					0	0	0	0	A	98193970	A	A	98193970	3	1	78	1	0	0	0	0	1	0	0	0	3338	1838	64	5	439	5	CHD1	5	98193970	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	38126075	98193970	82721290	88	15615											
DMXL1	1657	broad.mit.edu	37	chr5	118500343	118500343	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggggtggtgggtccggaataCccgcatcttacgcaaatgca	9	8	14	10	3	1	0	0	0	1	0	2	1	2	1	2	5	3	3	2	5	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:118500343C>T	uc003ksd.2	+	20	5025	c.4844C>T	c.(4843-4845)ACC>ATC	p.T1615I	DMXL1_uc010jcl.1_Missense_Mutation_p.T1615I	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1615										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GTCCGGAATACCCGCATCTTA	0.403													25	36					0	0	0	0	T	118500343	T	T	118500343	3	4	78	1	0	0	0	0	1	0	0	0	4616	507	18	4	4922	4	DMXL1	5	118500343	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	20306373	118500343	62414917	89	15616											
PCDHB7	56129	broad.mit.edu	37	chr5	140554405	140554405	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgctgcacgtgctcctggtGgacggcttctcccagcccta	5	9	11	16	3	1	0	0	0	1	0	3	1	2	1	3	3	3	4	3	3	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:140554405G>T	uc003lit.2	+	1	2163	c.1989G>T	c.(1987-1989)GTG>GTT	p.V663V		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	663	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTCCTGGTGGACGGCTTCT	0.697													13	45					9.16793e-09	1.07284e-08	1	0	T	140554405	T	T	140554405	2	4	78	1	0	0	0	0	0	0	0	1	11601	1335	47	4		4	PCDHB7	5	140554405	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	22054062	140554405	40360855	90	15617											
PCDHGA2	56113	broad.mit.edu	37	chr5	140719024	140719024	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatgcgcatgatgcagacgtAggtgagaacgcccttcagaa	13	7	12	9	3	1	4	1	2	0	3	1	5	1	4	1	1	3	3	1	1	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:140719024A>T	uc003ljk.1	+	1	671	c.486A>T	c.(484-486)GTA>GTT	p.V162V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.V162V	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	162	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCAGACGTAGGTGAGAACG	0.522													30	33					0	0	0	0	T	140719024	T	T	140719024	2	4	78	1	0	0	0	0	0	0	0	1	11608	407	15	5		5	PCDHGA2	5	140719024	Silent	SNP	A	TCGA-CN-6021-01A-11D-1683-08	164619	140719024	40196236	91	15618											
TCERG1	10915	broad.mit.edu	37	chr5	145850238	145850238	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	taaagagccaattaaagaacCctctgaagagcctctgccaa	16	7	7	11	0	2	4	0	1	2	3	2	4	2	4	4	0	4	0	4	0	8	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:145850238C>T	uc003lob.2	+	8	1479	c.1439C>T	c.(1438-1440)CCC>CTC	p.P480L	TCERG1_uc003loc.2_Missense_Mutation_p.P459L|TCERG1_uc011dbt.1_Missense_Mutation_p.P459L	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	480	Glu-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTAAAGAACCCTCTGAAGAG	0.388													13	24					0	0	0	0	T	145850238	T	T	145850238	3	4	78	1	0	0	0	0	1	0	0	0	15751	623	22	4	1469	4	TCERG1	5	145850238	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	5131214	145850238	35065022	92	15619											
PDGFRB	5159	broad.mit.edu	37	chr5	149497184	149497184	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caggccagggtggttacctgGctaggctgggggaaccctcc	6	7	16	12	0	0	0	0	0	0	0	1	1	1	1	4	7	2	3	4	7	3	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:149497184G>T	uc003lro.2	-	22	3603	c.3134C>A	c.(3133-3135)GCC>GAC	p.A1045D	PDGFRB_uc010jhd.2_Missense_Mutation_p.A884D	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	1045	Cytoplasmic (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TGGTTACCTGGCTAGGCTGGG	0.542			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								21	20					2.21704e-12	2.80776e-12	1	0	T	149497184	T	T	149497184	3	4	78	1	0	0	0	0	1	0	0	0	11716	1203	42	4	194	4	PDGFRB	5	149497184	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	3646946	149497184	31418076	93	15620											
ARSI	340075	broad.mit.edu	37	chr5	149677228	149677228	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcttccactcacccacgCggatggcagcctgcacggcg	7	5	12	17	4	1	0	1	0	0	0	2	1	2	1	3	3	3	4	3	3	0	1	rs147847092		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr5:149677228C>T	uc003lrv.2	-	2	1848	c.1259G>A	c.(1258-1260)CGC>CAC	p.R420H		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	420						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCACCCACGCGGATGGCAGC	0.622													15	45					0	0	0	0	T	149677228	T	T	149677228	3	4	78	1	0	0	0	0	1	0	0	0	996	768	27	1	454	1	ARSI	5	149677228	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	180044	149677228	31238032	94	15621											
IL17F	112744	broad.mit.edu	37	chr6	52101905	52101905	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccttgagcattgatgcagcCcaagttcctacactgggcct	8	11	9	13	0	0	2	0	2	0	0	2	2	2	2	4	1	4	3	4	1	2	4	rs146083682		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:52101905C>A	uc003pam.1	-	3	387	c.316G>T	c.(316-318)GGC>TGC	p.G106C	IL17F_uc003pal.1_Missense_Mutation_p.G52C	NM_052872	NP_443104	Q96PD4	IL17F_HUMAN	interleukin 17F precursor	106					cartilage development|inflammatory response|lymphotoxin A biosynthetic process|negative regulation of angiogenesis|proteoglycan metabolic process|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|regulation of interleukin-2 biosynthetic process|regulation of interleukin-6 biosynthetic process|regulation of interleukin-8 biosynthetic process|regulation of transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|cytokine binding|protein homodimerization activity			ovary(1)	1	Lung NSC(77;0.116)					TTGATGCAGCCCAAGTTCCTA	0.557													8	18					0.000274275	0.000286168	1	0	A	52101905	A	A	52101905	3	1	78	1	0	0	0	0	1	0	0	0	7677	623	22	4	179	4	IL17F	6	52101905	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08		52101905	119013162	95	15622											
BAI3	577	broad.mit.edu	37	chr6	70042897	70042897	+	Frame_Shift_Del	DEL	C	-	-																															taaaaagctcaaacacagagCcgggtaagctgcaattggtg																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:70042897delC	uc003pev.3	+	24	3633	c.3185delC	c.(3184-3186)GCCfs	p.A1062fs	BAI3_uc010kak.2_Frame_Shift_Del_p.A1062fs|BAI3_uc011dxx.1_Frame_Shift_Del_p.A268fs|BAI3_uc003pex.1_Frame_Shift_Del_p.A192fs	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1062	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AAACACAGAGCCGGGTAAGCT	0.388													---	---	---								-	70042897	-	-	70042897	7	5	78	1	0	1	0	1	0	0	0	0	1302	739	26	0	3271	0	BAI3	6	70042897	Frame_Shift_Del	DEL	C	TCGA-CN-6021-01A-11D-1683-08	17940992	70042897	101072170	96	15623											
IMPG1	3617	broad.mit.edu	37	chr6	76660760	76660760	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgccataaagaaaggtGgagcttctgacagggaggta	13	9	14	5	0	1	3	0	2	1	1	1	5	1	5	1	4	2	2	1	4	4	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:76660760G>A	uc003pik.1	-	13	1473	c.1343C>T	c.(1342-1344)CCA>CTA	p.P448L		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	448					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AAAGAAAGGTGGAGCTTCTGA	0.473													14	49					0	0	0	0	A	76660760	A	A	76660760	3	1	78	1	0	0	0	0	1	0	0	0	7767	1348	47	4	1070	4	IMPG1	6	76660760	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	6617863	76660760	94454307	97	15624											
C6orf165	154313	broad.mit.edu	37	chr6	88125575	88125575	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccctacagacatcaagaCtgtcagagaggtaacaggta	15	7	9	10	0	2	3	2	0	0	3	3	4	3	3	2	2	2	2	2	2	4	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:88125575C>G	uc003plv.2	+	5	547	c.455C>G	c.(454-456)ACT>AGT	p.T152S	C6orf165_uc003plw.2_5'UTR|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Missense_Mutation_p.T152S	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	152										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		GACATCAAGACTGTCAGAGAG	0.363													7	53					0	0	0	0	G	88125575	G	G	88125575	3	3	78	1	0	0	0	0	1	0	0	0	2351	565	20	4	469	4	C6orf165	6	88125575	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	11464815	88125575	82989492	98	15625											
ANKRD6	22881	broad.mit.edu	37	chr6	90340371	90340371	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagatctgatcagcaggctgGgccctgcgtcaacagaggca	10	6	13	12	1	3	3	2	1	1	2	3	3	3	3	1	3	3	3	1	3	1	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:90340371G>T	uc003pni.3	+	16	2173	c.1832G>T	c.(1831-1833)GGG>GTG	p.G611V	ANKRD6_uc003pne.3_Missense_Mutation_p.G606V|ANKRD6_uc003pnf.3_Missense_Mutation_p.G576V|ANKRD6_uc011dzy.1_Missense_Mutation_p.G611V|ANKRD6_uc010kcd.2_Missense_Mutation_p.G547V|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|ANKRD6_uc003pnh.3_Missense_Mutation_p.G207V|LYRM2_uc010kcf.1_Intron|ANKRD6_uc003pnj.3_Missense_Mutation_p.G207V	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	611							protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		CAGCAGGCTGGGCCCTGCGTC	0.582													6	10					0.00116845	0.00119641	1	0	T	90340371	T	T	90340371	3	4	78	1	0	0	0	0	1	0	0	0	685	1232	43	4	1875	4	ANKRD6	6	90340371	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2214796	90340371	80774696	99	15626											
GPR63	81491	broad.mit.edu	37	chr6	97246721	97246721	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatctggaaaggtctctgcAgactcatgagacccagtttg	10	11	10	10	0	4	2	2	1	2	2	5	4	4	3	1	2	1	2	1	2	1	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:97246721A>T	uc010kcl.2	-	3	1365	c.887T>A	c.(886-888)CTG>CAG	p.L296Q	GPR63_uc003pou.2_Missense_Mutation_p.L296Q	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	296	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AGGTCTCTGCAGACTCATGAG	0.498													18	56					0	0	0	0	T	97246721	T	T	97246721	3	4	78	1	0	0	0	0	1	0	0	0	6742	188	7	5	376	5	GPR63	6	97246721	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	6906350	97246721	73868346	100	15627											
ZBTB24	9841	broad.mit.edu	37	chr6	109802666	109802666	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctattctgaactgaattgttCactcttaactgtatttcttc	9	19	4	9	0	4	2	1	2	3	0	5	2	4	2	0	0	2	2	0	0	5	8			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:109802666C>G	uc003ptl.1	-	2	732	c.564G>C	c.(562-564)GTG>GTC	p.V188V	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Silent_p.V188V|ZBTB24_uc010kdt.1_RNA|ZBTB24_uc003ptm.2_Silent_p.V188V	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		CTGAATTGTTCACTCTTAACT	0.413													65	187					0	0	0	0	G	109802666	G	G	109802666	2	3	78	1	0	0	0	0	0	0	0	1	17598	813	29	2		2	ZBTB24	6	109802666	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	12555945	109802666	61312401	101	15628											
TUBE1	51175	broad.mit.edu	37	chr6	112397183	112397183	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccacaatgttattcattgCatcaaagggcttcttatgct	10	15	7	9	0	3	0	2	0	1	0	3	0	3	0	1	1	3	4	1	1	4	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:112397183C>G	uc003pvq.2	-	8	883	c.769G>C	c.(769-771)GCA>CCA	p.A257P	TUBE1_uc003pvr.2_Missense_Mutation_p.A182P	NM_016262	NP_057346	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	257					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			ovary(1)	1		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TTATTCATTGCATCAAAGGGC	0.383													59	89					0	0	0	0	G	112397183	G	G	112397183	3	3	78	1	0	0	0	0	1	0	0	0	16831	710	25	4	678	4	TUBE1	6	112397183	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	2594517	112397183	58717884	102	15629											
RFX6	222546	broad.mit.edu	37	chr6	117248568	117248568	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atataactcccggccaccgtCtagctatggcccatccctgc	8	9	7	17	2	1	0	0	0	1	0	3	0	3	0	5	2	3	1	5	2	4	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:117248568C>T	uc003pxm.2	+	17	2327	c.2264C>T	c.(2263-2265)TCT>TTT	p.S755F		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	755					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						CGGCCACCGTCTAGCTATGGC	0.517													14	36					0	0	0	0	T	117248568	T	T	117248568	3	4	78	1	0	0	0	0	1	0	0	0	13332	913	32	2	2330	2	RFX6	6	117248568	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	4851385	117248568	53866499	103	15630											
VNN1	8876	broad.mit.edu	37	chr6	133015242	133015242	+	Frame_Shift_Del	DEL	C	-	-																															ggtatcgcatggcttcttgtCcccaatatttgccacaacat																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:133015242delC	uc003qdo.2	-	3	441	c.421delG	c.(421-423)GACfs	p.D141fs		NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	141	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		GGCTTCTTGTCCCCAATATTT	0.468													---	---	---								-	133015242	-	-	133015242	7	5	78	1	0	1	0	1	0	0	0	0	17250	855	30	0	1140	0	VNN1	6	133015242	Frame_Shift_Del	DEL	C	TCGA-CN-6021-01A-11D-1683-08	15766674	133015242	38099825	104	15631											
EYA4	2070	broad.mit.edu	37	chr6	133846378	133846378	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggatggtgtagaagaagaaCaggcagcaaaaaaggtaacc	18	4	14	5	0	0	3	0	0	0	3	0	4	0	4	1	4	3	4	1	4	8	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:133846378C>A	uc003qec.3	+	19	2283	c.1825C>A	c.(1825-1827)CAG>AAG	p.Q609K	EYA4_uc011ecq.1_Intron|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Intron|EYA4_uc003qee.3_Missense_Mutation_p.Q586K|EYA4_uc011ecs.1_Missense_Mutation_p.Q615K|uc003qeg.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	609					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		AGAAGAAGAACAGGCAGCAAA	0.393													18	34					4.35082e-09	5.15404e-09	1	0	A	133846378	A	A	133846378	3	1	78	1	0	0	0	0	1	0	0	0	5356	479	17	4	2000	4	EYA4	6	133846378	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	831136	133846378	37268689	105	15632											
SASH1	23328	broad.mit.edu	37	chr6	148869664	148869664	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctatctgcagccagactcttCaaactgccgccaggccctga	9	8	8	16	1	3	2	1	1	2	1	3	2	3	2	4	1	4	1	4	1	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:148869664C>T	uc003qme.1	+	20	4189	c.3714C>T	c.(3712-3714)TTC>TTT	p.F1238F	SASH1_uc003qmf.1_Silent_p.F648F	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	1238	SAM 2.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CCAGACTCTTCAAACTGCCGC	0.557													26	79					0	0	0	0	T	148869664	T	T	148869664	2	4	78	1	0	0	0	0	0	0	0	1	13913	825	29	2		2	SASH1	6	148869664	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	15023286	148869664	22245403	106	15633											
SYNE1	23345	broad.mit.edu	37	chr6	152658020	152658020	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaatgttcagctccagctCagagtgcctcctcttcatgt	7	13	8	13	0	4	1	3	0	1	1	6	1	6	1	3	0	4	4	3	0	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:152658020C>T	uc010kiw.2	-	76	13086	c.12484G>A	c.(12484-12486)GAG>AAG	p.E4162K	SYNE1_uc003qot.3_Missense_Mutation_p.E4091K|SYNE1_uc003qou.3_Missense_Mutation_p.E4162K|SYNE1_uc010kja.1_Missense_Mutation_p.E867K|SYNE1_uc010kiz.2_5'Flank	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4162	Spectrin 11.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGCTCCAGCTCAGAGTGCCTC	0.473										HNSCC(10;0.0054)			22	104					0	0	0	0	T	152658020	T	T	152658020	3	4	78	1	0	0	0	0	1	0	0	0	15511	835	29	2	14266	2	SYNE1	6	152658020	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	3788356	152658020	18457047	107	15634											
SLC22A1	6580	broad.mit.edu	37	chr6	160543205	160543205	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgccaggcctggggcccGcgggcgaggccttccttggc	3	6	17	15	3	0	0	0	0	0	0	1	1	1	0	5	6	1	0	5	6	0	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:160543205G>T	uc003qtc.2	+	1	343	c.238G>T	c.(238-240)GCG>TCG	p.A80S	SLC22A1_uc003qtd.2_Missense_Mutation_p.A80S	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	80	Extracellular (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		CCTGGGGCCCGCGGGCGAGGC	0.662													24	83					2.21704e-12	2.80776e-12	1	0	T	160543205	T	T	160543205	3	4	78	1	0	0	0	0	1	0	0	0	14505	1087	38	3	240	3	SLC22A1	6	160543205	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	7885185	160543205	10571862	108	15635											
PARK2	5071	broad.mit.edu	37	chr6	162683677	162683677	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgagtcaagctctggggctCccgctcacagcctcccgccg	5	6	11	19	4	3	0	2	0	1	0	5	1	5	0	5	2	2	3	5	2	1	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:162683677C>A	uc003qtx.3	-	3	426	c.292G>T	c.(292-294)GAG>TAG	p.E98*	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Intron|PARK2_uc003qtw.3_5'UTR|PARK2_uc003qty.3_Nonsense_Mutation_p.E98*|PARK2_uc003qtz.3_Intron|PARK2_uc010kke.1_Nonsense_Mutation_p.E98*	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	98					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CTCTGGGGCTCCCGCTCACAG	0.587													17	45					0.00074312	0.000764977	1	0	A	162683677	A	A	162683677	4	1	78	1	0	0	0	0	0	1	0	0	11503	864	30	2	1145	2	PARK2	6	162683677	Nonsense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	2140472	162683677	8431390	109	15636											
PARK2	5071	broad.mit.edu	37	chr6	162683729	162683729	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtcgcctccagttgcattCatttcttgaccttttctcca	5	17	5	14	2	3	1	1	1	2	0	7	1	4	1	4	0	1	2	4	0	0	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:162683729C>A	uc003qtx.3	-	3	374	c.240G>T	c.(238-240)ATG>ATT	p.M80I	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Intron|PARK2_uc003qtw.3_5'UTR|PARK2_uc003qty.3_Missense_Mutation_p.M80I|PARK2_uc003qtz.3_Intron|PARK2_uc010kke.1_Missense_Mutation_p.M80I	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	80					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CAGTTGCATTCATTTCTTGAC	0.527													12	39					4.36969e-10	5.32383e-10	1	0	A	162683729	A	A	162683729	3	1	78	1	0	0	0	0	1	0	0	0	11503	826	29	2	1197	2	PARK2	6	162683729	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	52	162683729	8431338	110	15637											
MLLT4	4301	broad.mit.edu	37	chr6	168347424	168347424	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaggtaaaccccgaccaaaGagtgaaggctttgagctcta	13	8	10	10	1	2	3	1	2	1	1	2	4	2	3	3	2	2	3	3	2	5	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr6:168347424G>C	uc003qwd.2	+	26	3514	c.3372G>C	c.(3370-3372)AAG>AAC	p.K1124N	MLLT4_uc003qwb.1_Missense_Mutation_p.K1109N|MLLT4_uc003qwc.1_Missense_Mutation_p.K1125N|MLLT4_uc003qwg.1_Missense_Mutation_p.K434N	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1125					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CCCGACCAAAGAGTGAAGGCT	0.403			T	MLL	AL								26	52					0	0	0	0	C	168347424	C	C	168347424	3	2	78	1	0	0	0	0	1	0	0	0	9682	933	33	2	3477	2	MLLT4	6	168347424	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	5663695	168347424	2767643	111	15638											
THSD7A	221981	broad.mit.edu	37	chr7	11676343	11676343	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttcttcccccttaatgcActcaagaggtttctctaggc	8	13	6	14	0	3	1	1	0	2	1	5	1	4	1	3	2	1	2	3	2	3	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:11676343A>T	uc003ssf.3	-	2	688	c.436T>A	c.(436-438)TGC>AGC	p.C146S		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	146	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCCTTAATGCACTCAAGAGGT	0.473										HNSCC(18;0.044)			15	44					0	0	0	0	T	11676343	T	T	11676343	3	4	78	1	0	0	0	0	1	0	0	0	15945	159	6	5	4641	5	THSD7A	7	11676343	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08		11676343	147462320	112	15639											
HDAC9	9734	broad.mit.edu	37	chr7	18687533	18687533	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccctcatgttactttagaGggaaagccacccaacagcag	13	7	8	13	0	1	1	1	0	0	1	1	2	1	2	3	1	4	2	3	1	4	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:18687533G>C	uc003suh.2	+	9	1193	c.1152G>C	c.(1150-1152)GAG>GAC	p.E384D	HDAC9_uc003sue.2_Missense_Mutation_p.E384D|HDAC9_uc011jyd.1_Missense_Mutation_p.E384D|HDAC9_uc003sui.2_Missense_Mutation_p.E387D|HDAC9_uc003suj.2_Missense_Mutation_p.E343D|HDAC9_uc011jya.1_Missense_Mutation_p.E381D|HDAC9_uc003sua.1_Missense_Mutation_p.E362D|HDAC9_uc011jyb.1_Missense_Mutation_p.E340D|HDAC9_uc003sud.1_Missense_Mutation_p.E384D|HDAC9_uc011jyc.1_Missense_Mutation_p.E343D|HDAC9_uc003suf.1_Missense_Mutation_p.E415D|HDAC9_uc010kud.1_Missense_Mutation_p.E387D|HDAC9_uc011jye.1_Missense_Mutation_p.E356D|HDAC9_uc011jyf.1_Missense_Mutation_p.E307D|HDAC9_uc010kue.1_Missense_Mutation_p.E127D	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	384					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TTACTTTAGAGGGAAAGCCAC	0.498													6	7					0	0	0	0	C	18687533	C	C	18687533	3	2	78	1	0	0	0	0	1	0	0	0	7053	991	35	4	1195	4	HDAC9	7	18687533	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	7011190	18687533	140451130	113	15640											
BBS9	27241	broad.mit.edu	37	chr7	33217197	33217197	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctatggatcatttggtggtGtaaaaggtaatttgctttta	10	17	10	4	0	1	0	1	0	0	0	1	1	1	1	1	4	1	3	1	4	5	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:33217197G>T	uc003tdn.1	+	5	949	c.436G>T	c.(436-438)GTA>TTA	p.V146L	BBS9_uc003tdo.1_Missense_Mutation_p.V146L|BBS9_uc003tdp.1_Missense_Mutation_p.V146L|BBS9_uc003tdq.1_Missense_Mutation_p.V146L|BBS9_uc010kwn.1_RNA|BBS9_uc011kan.1_Missense_Mutation_p.V146L|BBS9_uc011kao.1_Missense_Mutation_p.V24L	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	146					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			ATTTGGTGGTGTAAAAGGTAA	0.353									Bardet-Biedl_syndrome				28	53					6.07407e-21	8.4423e-21	1	0	T	33217197	T	T	33217197	3	4	78	1	0	0	0	0	1	0	0	0	1344	1377	48	4	450	4	BBS9	7	33217197	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	14529664	33217197	125921466	114	15641											
ELMO1	9844	broad.mit.edu	37	chr7	36934481	36934481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcgggcgggactggaaatCttcctggttcatcctctcgg	7	11	12	11	3	3	0	1	0	2	0	7	2	5	2	2	5	0	1	2	5	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:36934481C>T	uc003tfk.1	-	17	1886	c.1579G>A	c.(1579-1581)GAT>AAT	p.D527N	ELMO1_uc003tfi.1_Missense_Mutation_p.D47N|ELMO1_uc003tfj.1_Missense_Mutation_p.D47N|ELMO1_uc011kbb.1_RNA|ELMO1_uc011kbc.1_Missense_Mutation_p.D431N|ELMO1_uc010kxg.1_Missense_Mutation_p.D527N	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	527					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GACTGGAAATCTTCCTGGTTC	0.478													16	50					0	0	0	0	T	36934481	T	T	36934481	3	4	78	1	0	0	0	0	1	0	0	0	5089	913	32	2	628	2	ELMO1	7	36934481	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	3717284	36934481	122204182	115	15642											
POLM	27434	broad.mit.edu	37	chr7	44119312	44119312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctcactgccttcaaagcctGctgcctcggccagtatctcc	6	10	7	18	1	3	0	2	0	1	0	5	0	3	0	6	1	4	2	6	1	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:44119312G>A	uc003tjt.2	-	4	592	c.500C>T	c.(499-501)GCA>GTA	p.A167V	POLM_uc003tju.2_Missense_Mutation_p.A167V|POLM_uc003tjx.2_Missense_Mutation_p.A167V|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_Intron|POLM_uc003tka.1_5'Flank|POLM_uc003tjz.3_Missense_Mutation_p.A167V|POLM_uc011kbu.1_Missense_Mutation_p.A134V|POLM_uc010kxy.2_Missense_Mutation_p.A167V	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	167					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3						TTCAAAGCCTGCTGCCTCGGC	0.652								DNA_polymerases_(catalytic_subunits)					19	41					0	0	0	0	A	44119312	A	A	44119312	3	1	78	1	0	0	0	0	1	0	0	0	12261	1319	46	4	1016	4	POLM	7	44119312	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	7184831	44119312	115019351	116	15643											
OGDH	4967	broad.mit.edu	37	chr7	44733439	44733439	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagatcggcttcaccaccGaccctcggatggcccgctcc	6	7	10	18	4	1	1	1	0	0	1	4	3	2	2	5	3	1	3	5	3	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:44733439G>T	uc003tln.2	+	11	1460	c.1351G>T	c.(1351-1353)GAC>TAC	p.D451Y	OGDH_uc011kbx.1_Missense_Mutation_p.D447Y|OGDH_uc011kby.1_Missense_Mutation_p.D301Y|OGDH_uc003tlp.2_Missense_Mutation_p.D462Y|OGDH_uc011kbz.1_Missense_Mutation_p.D246Y|OGDH_uc003tlo.1_Missense_Mutation_p.D284Y	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	451					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	CTTCACCACCGACCCTCGGAT	0.647													8	12					3.09899e-07	3.50914e-07	1	0	T	44733439	T	T	44733439	3	4	78	1	0	0	0	0	1	0	0	0	10893	1058	37	3	1562	3	OGDH	7	44733439	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	614127	44733439	114405224	117	15644											
ABCA13	154664	broad.mit.edu	37	chr7	48314857	48314857	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttgatcatttccacctgtCtccccaaggtgaagattcac	10	12	6	13	0	3	3	2	2	1	1	5	3	4	3	4	1	0	0	4	1	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:48314857C>G	uc003toq.2	+	17	5619	c.5594C>G	c.(5593-5595)TCT>TGT	p.S1865C	ABCA13_uc010kyr.2_Missense_Mutation_p.S1368C	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1865					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTCCACCTGTCTCCCCAAGGT	0.423													28	24					0	0	0	0	G	48314857	G	G	48314857	3	3	78	1	0	0	0	0	1	0	0	0	31	913	32	2	5489	2	ABCA13	7	48314857	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	3581418	48314857	110823806	118	15645											
MAGI2	9863	broad.mit.edu	37	chr7	79082487	79082487	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctctcataggccaccttGccgggcttcacctcccccag	5	8	8	20	2	2	0	2	0	1	0	4	0	3	0	7	2	1	2	7	2	1	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:79082487G>T	uc003ugx.2	-	1	404	c.150C>A	c.(148-150)GGC>GGA	p.G50G	MAGI2_uc003ugy.2_Silent_p.G50G|uc010lea.1_5'Flank	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	50	PDZ 1.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AGGCCACCTTGCCGGGCTTCA	0.642													31	77					4.74835e-14	6.15527e-14	1	0	T	79082487	T	T	79082487	2	4	78	1	0	0	0	0	0	0	0	1	9244	1306	46	4		4	MAGI2	7	79082487	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	30767630	79082487	80056176	119	15646											
CACNA2D1	781	broad.mit.edu	37	chr7	81693654	81693654	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagcatgtctttaggagatgCagctccttggatgtacctga	10	12	11	8	0	1	2	0	1	1	1	2	4	2	3	2	2	4	4	2	2	3	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:81693654C>A	uc003uhr.1	-	9	1001	c.745G>T	c.(745-747)GCA>TCA	p.A249S		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	249	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TTAGGAGATGCAGCTCCTTGG	0.313													9	28					1.76689e-08	2.04896e-08	1	0	A	81693654	A	A	81693654	3	1	78	1	0	0	0	0	1	0	0	0	2560	710	25	4	2654	4	CACNA2D1	7	81693654	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	2611167	81693654	77445009	120	15647											
PCLO	27445	broad.mit.edu	37	chr7	82585441	82585441	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctactttttcgagtcagtcGtctgtgtttccctgctgtta	4	18	9	10	2	2	0	1	0	1	0	5	1	3	0	1	0	2	4	1	0	2	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:82585441G>A	uc003uhx.2	-	5	5117	c.4828C>T	c.(4828-4830)CGA>TGA	p.R1610*	PCLO_uc003uhv.2_Nonsense_Mutation_p.R1610*	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1541					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CGAGTCAGTCGTCTGTGTTTC	0.428													34	224					0	0	0	0	A	82585441	A	A	82585441	4	1	78	1	0	0	0	0	0	1	0	0	11637	1153	40	1	10701	1	PCLO	7	82585441	Nonsense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	891787	82585441	76553222	121	15648											
PEX1	5189	broad.mit.edu	37	chr7	92147348	92147348	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccataagaggcagctggtaTtagtgcaactgtgtagaaaa	14	10	11	6	0	0	2	0	0	0	2	1	2	1	2	1	2	3	5	1	2	7	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:92147348T>C	uc003uly.2	-	5	577	c.481A>G	c.(481-483)ATA>GTA	p.I161V	PEX1_uc011khr.1_5'UTR|PEX1_uc010ley.2_Missense_Mutation_p.I161V|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	161					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GCAGCTGGTATTAGTGCAACT	0.393													14	33					0	0	0	0	C	92147348	C	C	92147348	3	2	78	1	0	0	0	0	1	0	0	0	11790	1493	52	5	3450	5	PEX1	7	92147348	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	9561907	92147348	66991315	122	15649											
PEG10	23089	broad.mit.edu	37	chr7	94293079	94293079	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcagcagctgctgccccaCcccctccaatagaggaagag	10	5	10	16	0	0	2	0	0	0	2	1	3	1	3	5	1	5	4	5	1	3	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:94293079C>G	uc011kie.1	+	2	656	c.439C>G	c.(439-441)CCC>GCC	p.P147A		NM_001040152	NP_001035242	Q86TG7	PEG10_HUMAN	paternally expressed 10 isoform RF1	71					apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			TGCTGCCCCACCCCCTCCAAT	0.582													7	13					0	0	0	0	G	94293079	G	G	94293079	3	3	78	1	0	0	0	0	1	0	0	0	11773	507	18	4	445	4	PEG10	7	94293079	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	2145731	94293079	64845584	123	15650											
SHFM1	7979	broad.mit.edu	37	chr7	96303092	96303092	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaacagcagaggaaagcacTgcacattcttcccttttggt	11	12	8	10	0	1	1	0	0	1	1	2	2	2	2	1	2	4	3	1	2	2	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:96303092T>A	uc010lfn.1	-	3	378	c.250A>T	c.(250-252)AGT>TGT	p.S84C		NM_006304	NP_006295	P60896	DSS1_HUMAN	split hand/foot malformation type 1	Error:Variant_position_missing_in_P60896_after_alignment					proteolysis	proteasome complex	peptidase activity|protein binding				0	all_cancers(62;4.24e-09)|all_epithelial(64;5.59e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0353)|Lung NSC(181;0.0987)					AGGAAAGCACTGCACATTCTT	0.453								Direct_reversal_of_damage|Homologous_recombination					12	31					0	0	0	0	A	96303092	A	A	96303092	3	1	78	1	0	0	0	0	1	0	0	0	14343	1595	55	5		5	SHFM1	7	96303092	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	2010013	96303092	62835571	124	15651											
ZAN	7455	broad.mit.edu	37	chr7	100345803	100345803	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaccccagagccagctgTggcagttgatgcaaccagca	13	5	11	12	0	0	3	0	1	0	2	0	3	0	3	4	1	5	5	4	1	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:100345803T>A	uc003uwj.2	+	10	1232	c.1067T>A	c.(1066-1068)GTG>GAG	p.V356E	ZAN_uc003uwk.2_Missense_Mutation_p.V356E|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	356	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GAGCCAGCTGTGGCAGTTGAT	0.622													14	37					0	0	0	0	A	100345803	A	A	100345803	3	1	78	1	0	0	0	0	1	0	0	0	17581	1696	59	5	1101	5	ZAN	7	100345803	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	4042711	100345803	58792860	125	15652											
LAMB1	3912	broad.mit.edu	37	chr7	107638890	107638890	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggctgtcaggattcagggtCtcatgataaggatcttggga	9	12	14	6	0	4	1	3	1	2	0	5	4	4	4	0	5	0	1	0	5	1	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:107638890C>T	uc003vew.2	-	4	596	c.261G>A	c.(259-261)GAG>GAA	p.E87E	LAMB1_uc003vev.2_Silent_p.E111E|LAMB1_uc003vex.2_Silent_p.E87E|LAMB1_uc010ljn.1_Silent_p.E173E	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	87	Laminin N-terminal.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GATTCAGGGTCTCATGATAAG	0.388													33	77					0	0	0	0	T	107638890	T	T	107638890	2	4	78	1	0	0	0	0	0	0	0	1	8650	912	32	2		2	LAMB1	7	107638890	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	7293087	107638890	51499773	126	15653											
ASZ1	136991	broad.mit.edu	37	chr7	117024803	117024803	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgatgtttgtttctttttgCaatctcacttggcatctttc	6	21	6	8	0	3	1	1	1	3	0	5	1	3	1	0	1	1	4	0	1	1	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:117024803C>A	uc003vjb.2	-	6	727	c.664G>T	c.(664-666)GCA>TCA	p.A222S	ASZ1_uc011kno.1_Missense_Mutation_p.A222S|ASZ1_uc011knp.1_Missense_Mutation_p.A14S	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	222	ANK 6.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TTTCTTTTTGCAATCTCACTT	0.333													28	70					2.08457e-15	2.72979e-15	1	0	A	117024803	A	A	117024803	3	1	78	1	0	0	0	0	1	0	0	0	1071	710	25	4	795	4	ASZ1	7	117024803	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	9385913	117024803	42113860	127	15654											
UBN2	254048	broad.mit.edu	37	chr7	138946205	138946205	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggggaatgacgtcccggaCttaaatctgagcagcggtga	10	8	14	9	3	1	3	0	3	1	0	2	5	2	5	1	4	2	1	1	4	3	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:138946205C>T	uc011kqr.1	+	6	1113	c.1113C>T	c.(1111-1113)GAC>GAT	p.D371D	UBN2_uc003vuv.2_Silent_p.D94D	NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	371										ovary(1)|skin(1)	2						ACGTCCCGGACTTAAATCTGA	0.483													25	67					0	0	0	0	T	138946205	T	T	138946205	2	4	78	1	0	0	0	0	0	0	0	1	16961	564	20	4		4	UBN2	7	138946205	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	21921402	138946205	20192458	128	15655											
UBN2	254048	broad.mit.edu	37	chr7	138946371	138946371	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctatctgagtcggggggtGaaaatggaaccaccacccag	11	6	12	12	1	1	2	0	2	1	0	2	3	1	3	4	4	1	0	4	4	4	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:138946371G>C	uc011kqr.1	+	6	1279	c.1279G>C	c.(1279-1281)GAA>CAA	p.E427Q	UBN2_uc003vuv.2_Missense_Mutation_p.E150Q	NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	427										ovary(1)|skin(1)	2						GTCGGGGGGTGAAAATGGAAC	0.483													12	70					0	0	0	0	C	138946371	C	C	138946371	3	2	78	1	0	0	0	0	1	0	0	0	16961	1291	45	2	1301	2	UBN2	7	138946371	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	166	138946371	20192292	129	15656											
FAM115C	285966	broad.mit.edu	37	chr7	143417115	143417115	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcggagcatggcctgcaatgCagcctggagccccatctgaa	9	7	12	13	1	1	1	0	1	1	0	2	3	1	3	4	3	5	3	4	3	2	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:143417115C>T	uc003wdf.2	+	3	1046	c.963C>T	c.(961-963)TGC>TGT	p.C321C	FAM115C_uc003wdg.2_Silent_p.C40C|FAM115C_uc011ktk.1_Silent_p.C321C|FAM115C_uc003wdh.2_Silent_p.C321C|FAM115C_uc011ktm.1_Silent_p.C321C|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron|FAM115C_uc011ktt.1_Silent_p.C157C|FAM115C_uc003wdi.1_Silent_p.C40C	NM_001130025	NP_001123497	A6NFQ2	F115C_HUMAN	hypothetical protein LOC285966 isoform A	321											0						GCCTGCAATGCAGCCTGGAGC	0.562													15	69					0	0	0	0	T	143417115	T	T	143417115	2	4	78	1	0	0	0	0	0	0	0	1	5434	718	25	4		4	FAM115C	7	143417115	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	4470744	143417115	15721548	130	15657											
KRBA1	84626	broad.mit.edu	37	chr7	149426299	149426299	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gactgagggctgaggcctgcGagtcagccgtctcgggcagg	6	6	18	11	3	2	2	1	2	1	0	3	4	2	2	2	4	2	2	2	4	0	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:149426299G>A	uc003wfz.2	+	13	2047	c.1648G>A	c.(1648-1650)GAG>AAG	p.E550K	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_Intron|KRBA1_uc003wgb.2_Intron	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	550										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGAGGCCTGCGAGTCAGCCGT	0.632													4	25					0	0	0	0	A	149426299	A	A	149426299	3	1	78	1	0	0	0	0	1	0	0	0	8478	1059	37	1	1694	1	KRBA1	7	149426299	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	6009184	149426299	9712364	131	15658											
SHH	6469	broad.mit.edu	37	chr7	155596377	155596377	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctccaggtgcaccgtggcCgagcccgggaagcagcctcc	6	5	14	16	3	0	0	0	0	0	0	2	2	2	1	6	3	5	3	6	3	1	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr7:155596377C>T	uc003wmk.1	-	3	757	c.606G>A	c.(604-606)TCG>TCA	p.S202S	SHH_uc003wmh.1_Intron|SHH_uc003wmi.1_Intron|SHH_uc003wmj.1_Silent_p.S115S	NM_000193	NP_000184	Q15465	SHH_HUMAN	sonic hedgehog preproprotein	202					androgen metabolic process|axon guidance|branching involved in ureteric bud morphogenesis|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|embryonic digit morphogenesis|hindbrain development|intein-mediated protein splicing|lymphoid progenitor cell differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|midbrain development|negative regulation of cell migration|negative regulation of kidney smooth muscle cell differentiation|negative regulation of ureter smooth muscle cell differentiation|negative thymic T cell selection|neural crest cell migration|neuroblast proliferation|patterning of blood vessels|positive regulation of alpha-beta T cell differentiation|positive regulation of immature T cell proliferation in thymus|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of T cell differentiation in thymus|positive regulation of ureter smooth muscle cell differentiation|positive thymic T cell selection|proteolysis|sclerotome development|stem cell development|thymus development|vasculogenesis|ventral midline development	cell surface|extracellular space|membrane raft|plasma membrane	calcium ion binding|laminin-1 binding|peptidase activity|signal transducer activity|zinc ion binding			central_nervous_system(3)|lung(1)	4	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00882)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCACCGTGGCCGAGCCCGGGA	0.677													5	18					0	0	0	0	T	155596377	T	T	155596377	2	4	78	1	0	0	0	0	0	0	0	1	14344	639	23	1		1	SHH	7	155596377	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	6170078	155596377	3542286	132	15659											
MTMR7	9108	broad.mit.edu	37	chr8	17159737	17159737	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattaggtaatctgtaactgActgtcggggctgcatcccct	8	12	10	11	1	1	1	0	1	1	0	3	1	2	1	2	3	2	4	2	3	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:17159737A>T	uc003wxm.2	-	13	1785	c.1546T>A	c.(1546-1548)TCA>ACA	p.S516T	MTMR7_uc003wxn.2_Missense_Mutation_p.S295T|MTMR7_uc011kya.1_Missense_Mutation_p.S150T|MTMR7_uc011kyb.1_Missense_Mutation_p.S107T	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	516							protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		TCTGTAACTGACTGTCGGGGC	0.453													43	97					0	0	0	0	T	17159737	T	T	17159737	3	4	78	1	0	0	0	0	1	0	0	0	10001	275	10	5	444	5	MTMR7	8	17159737	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08		17159737	129204285	133	15660											
HR	55806	broad.mit.edu	37	chr8	21973246	21973246	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaatgtccccacggccacCttcactgcttggaacacagc	9	9	8	15	1	1	0	1	0	0	0	2	1	2	1	4	2	3	2	4	2	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:21973246C>T	uc003xas.2	-	19	4202	c.3537G>A	c.(3535-3537)AAG>AAA	p.K1179K	HR_uc003xat.2_Silent_p.K1124K	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	1179							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CCACGGCCACCTTCACTGCTT	0.562													7	30					0	0	0	0	T	21973246	T	T	21973246	2	4	78	1	0	0	0	0	0	0	0	1	7386	680	24	4		4	HR	8	21973246	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	4813509	21973246	124390776	134	15661											
ADAM28	10863	broad.mit.edu	37	chr8	24168892	24168892	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggatgattgttattatcaaGgacatattcttaatgaaaag	16	14	8	3	0	2	2	1	2	1	0	2	4	2	4	0	2	0	1	0	2	7	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:24168892G>T	uc003xdy.2	+	5	408	c.325G>T	c.(325-327)GGA>TGA	p.G109*	ADAM28_uc003xdx.2_Nonsense_Mutation_p.G109*|ADAM28_uc011kzz.1_Translation_Start_Site|ADAM28_uc011laa.1_RNA	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	109					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TTATTATCAAGGACATATTCT	0.388													9	30					0.000274275	0.000286168	1	0	T	24168892	T	T	24168892	4	4	78	1	0	0	0	0	0	1	0	0	246	1001	35	4	343	4	ADAM28	8	24168892	Nonsense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2195646	24168892	122195130	135	15662											
PNMA2	10687	broad.mit.edu	37	chr8	26365761	26365761	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggggctgggacagcacTccctgagaatactcgcagtt	8	9	12	12	1	1	1	0	1	1	1	3	3	2	2	1	3	2	4	1	3	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:26365761T>G	uc003xez.2	-	3	1281	c.511A>C	c.(511-513)AGT>CGT	p.S171R		NM_007257	NP_009188	Q9UL42	PNMA2_HUMAN	paraneoplastic antigen MA2	171					apoptosis	nucleolus	protein binding				0		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		gggacagcactccctgagaat	0													15	75					0	0	0	0	G	26365761	G	G	26365761	3	3	78	1	0	0	0	0	1	0	0	0	12209	1551	54	5	587	5	PNMA2	8	26365761	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	2196869	26365761	119998261	136	15663											
ADRA1A	148	broad.mit.edu	37	chr8	26721956	26721956	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagcccggctcctcgttgatCtggcagatggtctcgtcctc	4	12	11	14	3	2	2	0	1	2	1	7	2	4	2	3	3	1	3	3	3	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:26721956C>T	uc003xfh.1	-	1	967	c.531G>A	c.(529-531)CAG>CAA	p.Q177Q	ADRA1A_uc003xfc.1_Silent_p.Q177Q|ADRA1A_uc010lul.1_Silent_p.Q177Q|ADRA1A_uc003xfd.1_RNA|ADRA1A_uc003xfe.1_Silent_p.Q177Q|ADRA1A_uc010lum.1_Silent_p.Q177Q|ADRA1A_uc003xff.1_RNA|ADRA1A_uc003xfg.1_Silent_p.Q177Q	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	177	Extracellular (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	CCTCGTTGATCTGGCAGATGG	0.627													8	27					0	0	0	0	T	26721956	T	T	26721956	2	4	78	1	0	0	0	0	0	0	0	1	334	912	32	2		2	ADRA1A	8	26721956	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	356195	26721956	119642066	137	15664											
UNC5D	137970	broad.mit.edu	37	chr8	35579781	35579781	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcttgggtgctgccgtcGtggccgttgcagtcctggtc	1	11	17	12	4	0	0	0	0	0	0	3	0	1	0	3	4	3	4	3	4	0	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:35579781G>T	uc003xjr.1	+	9	1499	c.1171G>T	c.(1171-1173)GTG>TTG	p.V391L	UNC5D_uc003xjs.1_Missense_Mutation_p.V386L|UNC5D_uc003xju.1_5'Flank|UNC5D_uc003xjt.1_Missense_Mutation_p.V149L	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	391	Helical; (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGCTGCCGTCGTGGCCGTTGC	0.522													57	136					3.89483e-19	5.31741e-19	1	0	T	35579781	T	T	35579781	3	4	78	1	0	0	0	0	1	0	0	0	17063	1145	40	3	1205	3	UNC5D	8	35579781	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	8857825	35579781	110784241	138	15665											
SNTG1	54212	broad.mit.edu	37	chr8	51571220	51571220	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagattatgtgcaagatcctCaaggtatgatcaatatgtag	14	12	10	5	0	2	3	2	1	0	2	3	4	3	3	1	1	1	3	1	1	7	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:51571220C>A	uc010lxy.1	+	16	1406	c.1035C>A	c.(1033-1035)CTC>CTA	p.L345L	SNTG1_uc003xqs.1_Silent_p.L345L|SNTG1_uc010lxz.1_Silent_p.L345L|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	345	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GCAAGATCCTCAAGGTATGAT	0.373													7	40					1.06961e-07	1.22926e-07	1	0	A	51571220	A	A	51571220	2	1	78	1	0	0	0	0	0	0	0	1	14938	813	29	2		2	SNTG1	8	51571220	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	15991439	51571220	94792802	139	15666											
KCNB2	9312	broad.mit.edu	37	chr8	73848928	73848928	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttgagcgggccaaaaggaaCggaagcatcgtttctatgaa	13	8	12	8	3	1	2	0	2	1	0	2	4	1	4	1	3	3	2	1	3	6	3	rs141965461		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:73848928C>T	uc003xzb.2	+	3	1926	c.1338C>T	c.(1336-1338)AAC>AAT	p.N446N		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	446	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CCAAAAGGAACGGAAGCATCG	0.453													36	82					0	0	0	0	T	73848928	T	T	73848928	2	4	78	1	0	0	0	0	0	0	0	1	8052	535	19	1		1	KCNB2	8	73848928	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	22277708	73848928	72515094	140	15667											
DCAF4L2	138009	broad.mit.edu	37	chr8	88886082	88886082	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctatacggcaatagttggCgaatctgaggaaacctagct	13	9	11	8	2	1	1	0	1	1	0	1	3	1	2	1	3	4	4	1	3	7	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:88886082C>A	uc003ydz.2	-	1	215	c.118G>T	c.(118-120)GCC>TCC	p.A40S		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	40										ovary(1)	1						CAATAGTTGGCGAATCTGAGG	0.522													29	45					2.14196e-07	2.4398e-07	1	0	A	88886082	A	A	88886082	3	1	78	1	0	0	0	0	1	0	0	0	4289	768	27	3	1073	3	DCAF4L2	8	88886082	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	15037154	88886082	57477940	141	15668											
OSR2	116039	broad.mit.edu	37	chr8	99961349	99961349	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acatgaaccactggacgctgGggtatcccaatgtgcacgag	11	7	12	11	2	0	1	0	1	0	0	1	3	1	2	2	3	2	3	2	3	3	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:99961349G>T	uc003yir.2	+	2	704	c.169G>T	c.(169-171)GGG>TGG	p.G57W	OSR2_uc010mbn.2_Missense_Mutation_p.G57W|OSR2_uc003yiq.2_Missense_Mutation_p.G57W|OSR2_uc011lgx.1_Missense_Mutation_p.G178W	NM_001142462	NP_001135934	Q8N2R0	OSR2_HUMAN	odd-skipped related 2 isoform a	57					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			CTGGACGCTGGGGTATCCCAA	0.667													20	58					1.01871e-10	1.25706e-10	1	0	T	99961349	T	T	99961349	3	4	78	1	0	0	0	0	1	0	0	0	11348	1232	43	4	171	4	OSR2	8	99961349	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	11075267	99961349	46402673	142	15669											
KCNV1	27012	broad.mit.edu	37	chr8	110980809	110980809	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtaacactgggtgattgtCatcccaagggagcgtaatcc	10	10	11	10	2	1	1	1	1	0	0	4	2	3	2	2	2	2	2	2	2	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:110980809C>A	uc003ynr.3	-	3	1353	c.1011G>T	c.(1009-1011)ATG>ATT	p.M337I	KCNV1_uc010mcw.2_Missense_Mutation_p.M337I	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	337	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GGGTGATTGTCATCCCAAGGG	0.338													16	37					3.32936e-07	3.75895e-07	1	0	A	110980809	A	A	110980809	3	1	78	1	0	0	0	0	1	0	0	0	8133	826	29	2	495	2	KCNV1	8	110980809	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	11019460	110980809	35383213	143	15670											
CSMD3	114788	broad.mit.edu	37	chr8	113318352	113318352	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacaaaaataggtaactcgcGttcctaccaaatagtctgtt	14	12	6	9	2	1	0	0	0	1	0	3	0	2	0	2	1	3	3	2	1	8	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr8:113318352G>T	uc003ynu.2	-	51	8114	c.7955C>A	c.(7954-7956)ACG>AAG	p.T2652K	CSMD3_uc003yns.2_Missense_Mutation_p.T1854K|CSMD3_uc003ynt.2_Missense_Mutation_p.T2612K|CSMD3_uc011lhx.1_Missense_Mutation_p.T2548K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2652	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTAACTCGCGTTCCTACCAA	0.383										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	70					4.35082e-09	5.15404e-09	1	0	T	113318352	T	T	113318352	3	4	78	1	0	0	0	0	1	0	0	0	3963	1145	40	3	3252	3	CSMD3	8	113318352	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2337543	113318352	33045670	144	15671											
CDKN2A	1029	broad.mit.edu	37	chr9	21971137	21971137	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgggtgagagtggcggggTcggcgcagttgggctccgcg	3	7	22	9	6	0	1	0	1	0	1	3	2	1	1	1	6	0	3	1	6	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr9:21971137T>A	uc003zpk.2	-	2	433	c.221A>T	c.(220-222)GAC>GTC	p.D74V	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.R129R	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	74			D -> N (in a bladder tumor).|D -> V (in a biliary tract tumor).|D -> Y (in CMM2; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.D74Y(5)|p.D74V(2)|p.D74N(2)|p.D74D(2)|p.L65fs*38(1)|p.V59fs*45(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.D74E(1)|p.C72fs*71(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		AGTGGCGGGGTCGGCGCAGTT	0.711		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			7	5					0	0	0	0	A	21971137	A	A	21971137	3	1	78	1	0	0	0	0	1	0	0	0	3176	1667	58	5	257	5	CDKN2A	9	21971137	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08		21971137	119242294	145	15672											
NPR2	4882	broad.mit.edu	37	chr9	35794092	35794092	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggcccaggccctcagagagGcctttcaggtatcatttgag	9	9	12	11	0	3	2	3	1	0	1	3	3	3	2	3	4	0	1	3	4	1	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr9:35794092G>T	uc003zyd.2	+	2	865	c.865G>T	c.(865-867)GCC>TCC	p.A289S	NPR2_uc010mlb.2_Missense_Mutation_p.A289S	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	289	Extracellular (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	cctcagagaggcctttcaggt	0.388													12	11					2.80697e-09	3.34577e-09	1	0	T	35794092	T	T	35794092	3	4	78	1	0	0	0	0	1	0	0	0	10649	1203	42	4	871	4	NPR2	9	35794092	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	13822955	35794092	105419339	146	15673											
TRPM6	140803	broad.mit.edu	37	chr9	77411725	77411725	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacataaattggaagtcctGggactggggaacatgtgaca	13	8	12	8	0	0	1	0	1	0	0	1	4	1	4	2	4	1	0	2	4	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr9:77411725G>A	uc004ajl.1	-	18	2561	c.2323C>T	c.(2323-2325)CAG>TAG	p.Q775*	TRPM6_uc004ajk.1_Nonsense_Mutation_p.Q770*|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_Nonsense_Mutation_p.Q153*	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	775	Extracellular (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TGGAAGTCCTGGGACTGGGGA	0.368													22	122					0	0	0	0	A	77411725	A	A	77411725	4	1	78	1	0	0	0	0	0	1	0	0	16657	1357	47	4	3833	4	TRPM6	9	77411725	Nonsense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	41617633	77411725	63801706	147	15674											
FAM120AOS	158293	broad.mit.edu	37	chr9	96209968	96209968	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actttgttattgacagaacaGcttctggaaatctgaaaaga	15	12	8	6	0	2	4	0	2	2	2	2	5	2	5	0	1	2	2	0	1	5	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr9:96209968G>A	uc004atu.3	-	3	1579	c.696C>T	c.(694-696)AGC>AGT	p.S232S	FAM120AOS_uc004atm.2_Intron|FAM120AOS_uc004atn.3_RNA|FAM120AOS_uc004ato.3_RNA|FAM120AOS_uc004atp.3_RNA|FAM120AOS_uc004atq.3_RNA|FAM120AOS_uc004atr.3_RNA|FAM120AOS_uc004ats.3_RNA|FAM120AOS_uc004att.3_RNA	NM_198841	NP_942138	Q5T036	F120S_HUMAN	hypothetical protein LOC158293	232											0						TGACAGAACAGCTTCTGGAAA	0.333													14	99					0	0	0	0	A	96209968	A	A	96209968	2	1	78	1	0	0	0	0	0	0	0	1	5444	962	34	4		4	FAM120AOS	9	96209968	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	18798243	96209968	45003463	148	15675											
TLR4	7099	broad.mit.edu	37	chr9	120470933	120470933	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accaagaacctggacctgagCtttaatcccctgaggcattt	11	10	8	12	0	0	3	0	2	0	1	1	4	1	4	5	2	2	2	5	2	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr9:120470933C>T	uc004bjz.2	+	2	477	c.186C>T	c.(184-186)AGC>AGT	p.S62S	TLR4_uc004bka.2_Silent_p.S22S|TLR4_uc004bkb.2_Intron	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	62	LRR 1.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TGGACCTGAGCTTTAATCCCC	0.443													16	121					0	0	0	0	T	120470933	T	T	120470933	2	4	78	1	0	0	0	0	0	0	0	1	16019	796	28	4		4	TLR4	9	120470933	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	24260965	120470933	20742498	149	15676											
TLR4	7099	broad.mit.edu	37	chr9	120474751	120474751	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgacaggaaaccccatccaGagtttagccctgggagcctt	10	9	10	12	0	0	2	0	1	0	1	1	4	1	4	5	2	3	1	5	2	2	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr9:120474751G>T	uc004bjz.2	+	3	636	c.345G>T	c.(343-345)CAG>CAT	p.Q115H	TLR4_uc004bka.2_Missense_Mutation_p.Q75H|TLR4_uc004bkb.2_5'UTR	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	115	LRR 3.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ACCCCATCCAGAGTTTAGCCC	0.453													40	33					1.96642e-18	2.6471e-18	1	0	T	120474751	T	T	120474751	3	4	78	1	0	0	0	0	1	0	0	0	16019	933	33	2	355	2	TLR4	9	120474751	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	3818	120474751	20738680	150	15677											
DBC1	1620	broad.mit.edu	37	chr9	122004443	122004443	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactttgagtggcattccctGacttcctgtcgaggcgactt	6	13	10	12	2	0	2	0	2	0	0	3	4	2	2	2	2	0	1	2	2	0	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr9:122004443G>T	uc004bkc.2	-	4	917	c.461C>A	c.(460-462)TCA>TAA	p.S154*	DBC1_uc004bkd.2_Nonsense_Mutation_p.S154*	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	154	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GGCATTCCCTGACTTCCTGTC	0.478													38	18					6.19805e-25	8.87082e-25	1	0	T	122004443	T	T	122004443	4	4	78	1	0	0	0	0	0	1	0	0	4264	1294	45	2	1844	2	DBC1	9	122004443	Nonsense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1529692	122004443	19208988	151	15678											
FNBP1	23048	broad.mit.edu	37	chr9	132658199	132658199	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcatttctccgaatgcgggtCcagccatcgcctttgtcttc	5	14	8	14	3	3	0	1	0	2	0	7	1	4	0	4	1	2	0	4	1	1	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr9:132658199C>T	uc004byw.1	-	16	1983	c.1764G>A	c.(1762-1764)TGG>TGA	p.W588*	FNBP1_uc011mbv.1_Nonsense_Mutation_p.W578*|FNBP1_uc011mbw.1_Nonsense_Mutation_p.W583*|FNBP1_uc004bza.2_Nonsense_Mutation_p.W522*|FNBP1_uc004byz.1_Nonsense_Mutation_p.W559*|FNBP1_uc004byv.1_5'Flank|FNBP1_uc011mbu.1_Nonsense_Mutation_p.W216*|FNBP1_uc004byx.1_Nonsense_Mutation_p.W504*|FNBP1_uc004byy.1_Nonsense_Mutation_p.W494*	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	588	Required for self-association and induction of membrane tubulation.|Interaction with FASLG.|SH3.|Interaction with PDE6G (By similarity).|Interaction with DNM1 and DNM3.|Required for interaction with TNKS.|Interaction with DNM2 and WASL.|Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		GAATGCGGGTCCAGCCATCGC	0.413			T	MLL	AML								27	32					0	0	0	0	T	132658199	T	T	132658199	4	4	78	1	0	0	0	0	0	1	0	0	5997	856	30	2	97	2	FNBP1	9	132658199	Nonsense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	10653756	132658199	8555232	152	15679											
NOTCH1	4851	broad.mit.edu	37	chr9	139413070	139413072	+	In_Frame_Del	DEL	AGA	-	-																															gccatggggacactcgcagtAgaaggaggccacacggtcat																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr9:139413070_139413072delAGA	uc004chz.2	-	6	1070_1072	c.1070_1072delTCT	c.(1069-1074)TTCTAC>TAC	p.F357del		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	357	Extracellular (Potential).|EGF-like 9; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CACTCGCAGTAGAAGGAGGCCAC	0.655			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								-	139413072	-	-	139413070	7	5	78	1	0	1	0	1	0	0	0	0	10601	420	15	0	6711	0	NOTCH1	9	139413070	In_Frame_Del	DEL	AGA	TCGA-CN-6021-01A-11D-1683-08	6754871	139413070	1800361	153	15680											
TAF3	83860	broad.mit.edu	37	chr10	8006137	8006137	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactcagctcaataaatactCaaaagatcccaccaatgctt	16	9	3	13	0	3	1	3	0	0	1	4	1	4	1	2	0	3	2	2	0	7	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:8006137C>T	uc010qbd.1	+	3	664	c.664C>T	c.(664-666)CAA>TAA	p.Q222*		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	222					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						AATAAATACTCAAAAGATCCC	0.507													27	46					0	0	0	0	T	8006137	T	T	8006137	4	4	78	1	0	0	0	0	0	1	0	0	15591	827	29	2	674	2	TAF3	10	8006137	Nonsense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08		8006137	127528610	154	15681											
MRC1	4360	broad.mit.edu	37	chr10	17891588	17891588	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttttgtttctagaaagtGatgtgcctactcactgtcct	7	17	7	10	0	2	2	1	1	1	1	3	2	3	2	3	0	2	1	3	0	3	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:17891588G>T	uc001ipk.2	+	7	1172	c.1069G>T	c.(1069-1071)GAT>TAT	p.D357Y		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	357	Extracellular (Potential).				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						TCTAGAAAGTGATGTGCCTAC	0.338													18	54					5.3912e-06	5.93032e-06	1	0	T	17891588	T	T	17891588	3	4	78	1	0	0	0	0	1	0	0	0	9809	1290	45	2	1095	2	MRC1	10	17891588	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	9885451	17891588	117643159	155	15682											
ARHGAP12	94134	broad.mit.edu	37	chr10	32197132	32197132	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggagctgctgctaagttCatcaccagattcagaatctt	11	12	9	9	0	4	2	3	0	1	2	4	3	4	3	1	1	3	4	1	1	2	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:32197132C>A	uc001ivz.1	-	3	922	c.652G>T	c.(652-654)GAA>TAA	p.E218*	ARHGAP12_uc001ivy.1_Nonsense_Mutation_p.E216*|ARHGAP12_uc009xls.2_Nonsense_Mutation_p.E216*|ARHGAP12_uc001iwb.1_Nonsense_Mutation_p.E216*|ARHGAP12_uc001iwc.1_Nonsense_Mutation_p.E216*|ARHGAP12_uc009xlq.1_Nonsense_Mutation_p.E216*|ARHGAP12_uc001iwd.1_Nonsense_Mutation_p.E216*|ARHGAP12_uc009xlr.1_Nonsense_Mutation_p.E216*	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	218					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				CTGCTAAGTTCATCACCAGAT	0.378													16	56					6.72482e-11	8.32494e-11	1	0	A	32197132	A	A	32197132	4	1	78	1	0	0	0	0	0	1	0	0	865	835	29	2	1960	2	ARHGAP12	10	32197132	Nonsense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	14305544	32197132	103337615	156	15683											
ZNF33A	7581	broad.mit.edu	37	chr10	38345088	38345088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atctttctgtgtaaaatcagGacttattttccatgagagaa	13	15	7	6	0	3	2	1	1	2	1	4	4	4	3	1	1	0	1	1	1	4	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:38345088G>A	uc001izh.2	+	5	2211	c.2033G>A	c.(2032-2034)GGA>GAA	p.G678E	ZNF33A_uc001izg.2_Missense_Mutation_p.G679E|ZNF33A_uc010qev.1_Missense_Mutation_p.G685E|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	678	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						GTAAAATCAGGACTTATTTTC	0.388													20	92					0	0	0	0	A	38345088	A	A	38345088	3	1	78	1	0	0	0	0	1	0	0	0	17921	1174	41	2	2050	2	ZNF33A	10	38345088	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	6147956	38345088	97189659	157	15684											
RBP3	5949	broad.mit.edu	37	chr10	48387902	48387902	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaggtgtgggtctccggaGagcatctgcaggtcagcccc	6	9	14	12	1	4	1	2	0	2	1	5	2	4	1	3	4	3	2	3	4	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:48387902G>T	uc001jez.2	-	1	3090	c.2976C>A	c.(2974-2976)CTC>CTA	p.L992L		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	992	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GGTCTCCGGAGAGCATCTGCA	0.602													31	91					6.04164e-23	8.52027e-23	1	0	T	48387902	T	T	48387902	2	4	78	1	0	0	0	0	0	0	0	1	13222	929	33	2		2	RBP3	10	48387902	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	10042814	48387902	87146845	158	15685											
C10orf72	196740	broad.mit.edu	37	chr10	50255051	50255051	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgacttttctctgtggttTcagcagcttcggtttatgga	5	17	11	8	2	2	1	1	1	1	0	4	2	2	2	0	3	2	4	0	3	1	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:50255051T>A	uc001jhf.2	-	7	843	c.814A>T	c.(814-816)AAA>TAA	p.K272*		NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	272	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						CTCTGTGGTTTCAGCAGCTTC	0.468													5	174					0	0	0	0	A	50255051	A	A	50255051	4	1	78	1	0	0	0	0	0	1	0	0	1621	1792	62	5	156	5	C10orf72	10	50255051	Nonsense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	1867149	50255051	85279696	159	15686											
SLC18A3	6572	broad.mit.edu	37	chr10	50820091	50820091	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcggtggcctacgcgctcggGcccatagtggcaggccacat	6	7	14	14	4	0	0	0	0	0	0	2	0	0	0	3	5	1	2	3	5	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:50820091G>A	uc001jhw.2	+	1	1745	c.1305G>A	c.(1303-1305)GGG>GGA	p.G435G	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	435	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						ACGCGCTCGGGCCCATAGTGG	0.627													10	18					0	0	0	0	A	50820091	A	A	50820091	2	1	78	1	0	0	0	0	0	0	0	1	14492	1190	42	4		4	SLC18A3	10	50820091	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	565040	50820091	84714656	160	15687											
CHAT	1103	broad.mit.edu	37	chr10	50828553	50828553	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggcaggtgtctgagtacTggctgaatgacatgtatctc	8	11	12	10	1	2	3	0	3	2	0	3	3	2	3	1	3	1	4	1	3	3	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:50828553T>G	uc001jhz.2	+	4	745	c.592T>G	c.(592-594)TGG>GGG	p.W198G	CHAT_uc001jhv.1_Missense_Mutation_p.W80G|CHAT_uc001jhx.1_Missense_Mutation_p.W80G|CHAT_uc001jhy.1_Missense_Mutation_p.W80G|CHAT_uc001jia.2_Missense_Mutation_p.W80G|CHAT_uc010qgs.1_Missense_Mutation_p.W80G	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	198					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GTCTGAGTACTGGCTGAATGA	0.597													40	85					0	0	0	0	G	50828553	G	G	50828553	3	3	78	1	0	0	0	0	1	0	0	0	3328	1580	55	5	650	5	CHAT	10	50828553	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	8462	50828553	84706194	161	15688											
P4HA1	5033	broad.mit.edu	37	chr10	74813238	74813238	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcgccttcatccagttgccTtagggcttgttccatccaca	6	13	7	15	1	1	0	1	0	0	0	5	0	4	0	5	1	1	3	5	1	1	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:74813238T>A	uc010qka.1	-	7	908	c.574A>T	c.(574-576)AGG>TGG	p.R192W	P4HA1_uc001jtg.2_Missense_Mutation_p.R192W|P4HA1_uc001jth.2_Missense_Mutation_p.R192W|P4HA1_uc010qkb.1_Missense_Mutation_p.R192W|P4HA1_uc001jti.2_RNA	NM_001142595	NP_001136067	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha I subunit isoform 2	192						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			ovary(1)	1	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCCAGTTGCCTTAGGGCTTGT	0.443													37	90					0	0	0	0	A	74813238	A	A	74813238	3	1	78	1	0	0	0	0	1	0	0	0	11410	1608	56	5	1145	5	P4HA1	10	74813238	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	23984685	74813238	60721509	162	15689											
PLCE1	51196	broad.mit.edu	37	chr10	95791541	95791541	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttggccaaaaattgtgataaTaagaatgagcagctgcagtg	15	10	11	5	0	0	3	0	2	0	1	0	3	0	3	1	1	3	3	1	1	5	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:95791541T>C	uc001kjk.2	+	2	1372	c.738T>C	c.(736-738)AAT>AAC	p.N246N	PLCE1_uc010qnx.1_Silent_p.N246N	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	246					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				ATTGTGATAATAAGAATGAGC	0.398													21	25					0	0	0	0	C	95791541	C	C	95791541	2	2	78	1	0	0	0	0	0	0	0	1	12089	1403	49	5		5	PLCE1	10	95791541	Silent	SNP	T	TCGA-CN-6021-01A-11D-1683-08	20978303	95791541	39743206	163	15690											
CYP2C9	1559	broad.mit.edu	37	chr10	96702062	96702062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaccgtgttcaagaggaaGcccgctgccttgtggaggag	9	7	16	9	2	1	1	1	0	0	1	1	5	1	5	3	4	2	2	3	4	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:96702062G>A	uc001kka.3	+	3	470	c.445G>A	c.(445-447)GCC>ACC	p.A149T	CYP2C9_uc009xut.2_Missense_Mutation_p.A149T|CYP2C9_uc001kjz.2_Missense_Mutation_p.A149T	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	149					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TCAAGAGGAAGCCCGCTGCCT	0.502													34	41					0	0	0	0	A	96702062	A	A	96702062	3	1	78	1	0	0	0	0	1	0	0	0	4185	971	34	4	455	4	CYP2C9	10	96702062	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	910521	96702062	38832685	164	15691											
HPSE2	60495	broad.mit.edu	37	chr10	100481543	100481543	+	Frame_Shift_Del	DEL	C	-	-																															aatcctttcccaactggctgCcatttactgcccggccatgc																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:100481543delC	uc001kpn.1	-	5	887	c.827delG	c.(826-828)GGCfs	p.G276fs	HPSE2_uc009xwc.1_Frame_Shift_Del_p.G266fs|HPSE2_uc001kpo.1_Frame_Shift_Del_p.G208fs|HPSE2_uc009xwd.1_Frame_Shift_Del_p.G154fs	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	276					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		CAACTGGCTGCCATTTACTGC	0.483													---	---	---								-	100481543	-	-	100481543	7	5	78	1	0	1	0	1	0	0	0	0	7384	739	26	0	1021	0	HPSE2	10	100481543	Frame_Shift_Del	DEL	C	TCGA-CN-6021-01A-11D-1683-08	3779481	100481543	35053204	165	15692											
SHOC2	8036	broad.mit.edu	37	chr10	112724466	112724466	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctatacacatattgccatCatcaatcaaagagttgactc	15	12	4	10	0	4	2	3	1	1	1	5	2	4	2	1	0	2	1	1	0	5	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:112724466C>G	uc001kzl.3	+	2	699	c.350C>G	c.(349-351)TCA>TGA	p.S117*	SHOC2_uc009xxx.2_Nonsense_Mutation_p.S117*|SHOC2_uc010qrg.1_Intron|SHOC2_uc001kzn.2_Nonsense_Mutation_p.S117*	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	117	LRR 1.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		ATATTGCCATCATCAATCAAA	0.383													27	47					0	0	0	0	G	112724466	G	G	112724466	4	3	78	1	0	0	0	0	0	1	0	0	14352	838	29	2	352	2	SHOC2	10	112724466	Nonsense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	12242923	112724466	22810281	166	15693											
DMBT1	1755	broad.mit.edu	37	chr10	124336232	124336232	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaagatgctggtgttatcTgctcaggtaggcatccagat	9	12	13	7	0	2	3	1	1	1	2	3	3	3	3	1	3	2	5	1	3	3	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:124336232T>A	uc001lgk.1	+	7	707	c.601T>A	c.(601-603)TGC>AGC	p.C201S	DMBT1_uc001lgl.1_Missense_Mutation_p.C201S|DMBT1_uc001lgm.1_Missense_Mutation_p.C201S|DMBT1_uc009xzz.1_Missense_Mutation_p.C201S|DMBT1_uc010qtx.1_Missense_Mutation_p.C201S|DMBT1_uc009yaa.1_Missense_Mutation_p.C53S	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	201	SRCR 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGGTGTTATCTGCTCAGGTAG	0.358													21	31					0	0	0	0	A	124336232	A	A	124336232	3	1	78	1	0	0	0	0	1	0	0	0	4599	1580	55	5	627	5	DMBT1	10	124336232	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	11611766	124336232	11198515	167	15694											
MGMT	4255	broad.mit.edu	37	chr10	131565234	131565234	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagggagcgggagctacctcGggctccccgcctgctggccg	5	5	16	15	4	0	0	0	0	0	0	2	2	1	2	5	4	4	3	5	4	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr10:131565234G>A	uc001lkh.2	+	5	716	c.690G>A	c.(688-690)TCG>TCA	p.S230S		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	199										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		GAGCTACCTCGGGCTCCCCGC	0.632								Direct_reversal_of_damage					15	17					0	0	0	0	A	131565234	A	A	131565234	2	1	78	1	0	0	0	0	0	0	0	1	9610	1103	39	1		1	MGMT	10	131565234	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	7229002	131565234	3969513	168	15695											
MUC5B	727897	broad.mit.edu	37	chr11	1271213	1271213	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctccacagtgctgaccaCgaaggccaccacgacaaggg	12	3	10	16	2	0	1	0	1	0	0	1	3	1	1	5	2	1	1	5	2	2	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:1271213C>T	uc009ycr.1	+	51	14648	c.14522C>T	c.(14521-14523)ACG>ATG	p.T4841M	MUC5B_uc001ltb.2_Missense_Mutation_p.T4371M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4368	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTGCTGACCACGAAGGCCACC	0.642													10	78					0	0	0	0	T	1271213	T	T	1271213	3	4	78	1	0	0	0	0	1	0	0	0	10032	536	19	1	13234	1	MUC5B	11	1271213	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08		1271213	133735303	169	15696											
OR52E4	390081	broad.mit.edu	37	chr11	5906037	5906037	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctgcgtctgccattctgtgGgcataacatcgtacctcaca	8	12	8	13	2	4	0	1	0	3	0	5	0	4	0	2	1	4	2	2	1	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:5906037G>T	uc010qzs.1	+	1	515	c.515G>T	c.(514-516)GGG>GTG	p.G172V	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCATTCTGTGGGCATAACATC	0.453													32	57					8.73648e-17	1.15984e-16	1	0	T	5906037	T	T	5906037	3	4	78	1	0	0	0	0	1	0	0	0	11170	1232	43	4	517	4	OR52E4	11	5906037	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	4634824	5906037	129100479	170	15697											
NRIP3	56675	broad.mit.edu	37	chr11	9009771	9009771	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaagggacacggggaccgCttcggagcttagacaggttg	9	6	15	11	3	0	1	0	0	0	1	1	4	0	4	2	5	1	3	2	5	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:9009771C>A	uc001mhg.2	-	2	347	c.233G>T	c.(232-234)AGC>ATC	p.S78I	NRIP3_uc010rbu.1_Missense_Mutation_p.S78I	NM_020645	NP_065696	Q9NQ35	NRIP3_HUMAN	nuclear receptor interacting protein 3	78					proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)		ACGGGGACCGCTTCGGAGCTT	0.493													42	54					2.26627e-22	3.18436e-22	1	0	A	9009771	A	A	9009771	3	1	78	1	0	0	0	0	1	0	0	0	10708	797	28	4	516	4	NRIP3	11	9009771	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	3103734	9009771	125996745	171	15698											
WEE1	7465	broad.mit.edu	37	chr11	9598747	9598747	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggacagcattctcatgtaGttcgatatttctctgcgtgg	7	16	10	8	2	2	0	1	0	2	0	5	2	2	1	0	2	2	3	0	2	2	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:9598747G>T	uc001mhs.2	+	5	1331	c.1078G>T	c.(1078-1080)GTT>TTT	p.V360F	WEE1_uc001mht.2_Missense_Mutation_p.V146F|WEE1_uc001mhu.2_Missense_Mutation_p.V146F	NM_003390	NP_003381	P30291	WEE1_HUMAN	WEE1 tyrosine kinase isoform 1	360	Protein kinase.				blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	5				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		TTCTCATGTAGTTCGATATTT	0.358													35	61					5.8336e-16	7.69157e-16	1	0	T	9598747	T	T	9598747	3	4	78	1	0	0	0	0	1	0	0	0	17412	1029	36	4	1096	4	WEE1	11	9598747	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	588976	9598747	125407769	172	15699											
SAAL1	113174	broad.mit.edu	37	chr11	18112026	18112026	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctgaatcatacaaacagTgcaataacacctgcctacaa	16	8	6	11	0	2	1	1	1	1	0	2	1	2	1	2	1	6	1	2	1	7	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:18112026T>A	uc001mnq.2	-	5	478	c.428A>T	c.(427-429)CAC>CTC	p.H143L	SAAL1_uc001mnr.2_Missense_Mutation_p.H143L|SAAL1_uc001mns.2_RNA|SAAL1_uc009yhf.2_Missense_Mutation_p.H143L	NM_138421	NP_612430	Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	143					acute-phase response	extracellular region	binding				0						ATACAAACAGTGCAATAACAC	0.318													3	16					0	0	0	0	A	18112026	A	A	18112026	3	1	78	1	0	0	0	0	1	0	0	0	13866	1696	59	5	1028	5	SAAL1	11	18112026	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	8513279	18112026	116894490	173	15700											
ARHGAP1	392	broad.mit.edu	37	chr11	46701258	46701258	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggggctcaggaagctcccGgaggaaggtcttgaggatga	10	6	17	8	1	2	2	1	2	1	0	3	6	3	6	1	7	1	2	1	7	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:46701258G>A	uc001ndd.2	-	11	1036	c.967C>T	c.(967-969)CGG>TGG	p.R323W		NM_004308	NP_004299	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	323	Rho-GAP.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			skin(1)	1		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		GGAAGCTCCCGGAGGAAGGTC	0.612													15	80					0	0	0	0	A	46701258	A	A	46701258	3	1	78	1	0	0	0	0	1	0	0	0	861	1115	39	1	364	1	ARHGAP1	11	46701258	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	28589232	46701258	88305258	174	15701											
AGBL2	79841	broad.mit.edu	37	chr11	47712048	47712048	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactgacaggaggtagcatTgcaaatcagtgtatgtatat	13	11	10	7	0	1	1	1	1	0	0	1	2	1	2	1	2	2	5	1	2	5	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:47712048T>A	uc001ngg.2	-	9	1311	c.1211A>T	c.(1210-1212)CAA>CTA	p.Q404L	AGBL2_uc001ngf.2_RNA|AGBL2_uc010rhq.1_Missense_Mutation_p.Q366L|AGBL2_uc001ngh.1_Missense_Mutation_p.Q348L	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic	404					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						GAGGTAGCATTGCAAATCAGT	0.468													14	58					0	0	0	0	A	47712048	A	A	47712048	3	1	78	1	0	0	0	0	1	0	0	0	376	1812	63	5	1537	5	AGBL2	11	47712048	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	1010790	47712048	87294468	175	15702											
OR5D18	219438	broad.mit.edu	37	chr11	55587247	55587247	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagggaatattgggttgattGtgatcatcaaaatcaacccc	13	12	9	7	0	3	2	3	2	0	0	3	3	3	3	2	2	1	1	2	2	6	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:55587247G>T	uc010rin.1	+	1	142	c.142G>T	c.(142-144)GTG>TTG	p.V48L		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TGGGTTGATTGTGATCATCAA	0.458													27	91					1.5548e-18	2.10034e-18	1	0	T	55587247	T	T	55587247	3	4	78	1	0	0	0	0	1	0	0	0	11211	1377	48	4	144	4	OR5D18	11	55587247	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	7875199	55587247	79419269	176	15703											
OR1S2	219958	broad.mit.edu	37	chr11	57971606	57971606	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgatggtggtttggttttcTtgatgcatatttctgctgat	5	20	12	4	0	2	3	0	3	2	0	2	3	2	3	0	3	2	4	0	3	1	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:57971606T>G	uc010rkb.1	-	1	48	c.48A>C	c.(46-48)CAA>CAC	p.Q16H		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				TTTGGTTTTCTTGATGCATAT	0.408													11	66					0	0	0	0	G	57971606	G	G	57971606	3	3	78	1	0	0	0	0	1	0	0	0	11027	1606	56	5	932	5	OR1S2	11	57971606	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	2384359	57971606	77034910	177	15704											
SLC22A11	55867	broad.mit.edu	37	chr11	64329824	64329824	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggccaggcggcgctgggCggcctggcctttgccctgcg	2	6	18	15	4	0	0	0	0	0	0	0	0	0	0	4	6	2	2	4	6	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:64329824C>T	uc001oai.2	+	4	1112	c.738C>T	c.(736-738)GGC>GGT	p.G246G	SLC22A11_uc001oah.1_Missense_Mutation_p.R212W|SLC22A11_uc001oaj.2_Silent_p.G246G|SLC22A11_uc009ypq.2_Silent_p.G246G|SLC22A11_uc001oak.1_Silent_p.G75G	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	246	Helical; (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	CGGCGCTGGGCGGCCTGGCCT	0.632													17	99					0	0	0	0	T	64329824	T	T	64329824	2	4	78	1	0	0	0	0	0	0	0	1	14507	755	27	1		1	SLC22A11	11	64329824	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	6358218	64329824	70676692	178	15705											
PRCP	5547	broad.mit.edu	37	chr11	82561547	82561547	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaaattcaagtgtctggaatCctaaagaaatataacaaaga	20	9	7	5	0	2	2	1	0	1	2	3	4	3	3	1	1	1	0	1	1	9	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:82561547C>T	uc001ozs.2	-	4	525	c.412G>A	c.(412-414)GAT>AAT	p.D138N	PRCP_uc001ozr.2_Missense_Mutation_p.D159N	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	138					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						TGTCTGGAATCCTAAAGAAAT	0.393													21	53					0	0	0	0	T	82561547	T	T	82561547	3	4	78	1	0	0	0	0	1	0	0	0	12511	869	30	2	1102	2	PRCP	11	82561547	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	18231723	82561547	52444969	179	15706											
KBTBD3	143879	broad.mit.edu	37	chr11	105924356	105924356	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcgaaccgttcgacaacAtttccctttgcaaccacctg	10	10	6	15	3	0	0	0	0	0	0	3	2	1	0	4	0	4	2	4	0	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:105924356A>T	uc001pja.2	-	4	1700	c.1060T>A	c.(1060-1062)TGT>AGT	p.C354S	KBTBD3_uc001pjb.2_Missense_Mutation_p.C354S|KBTBD3_uc009yxm.2_Missense_Mutation_p.C275S	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	350	Kelch 2.									ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		GTTCGACAACATTTCCCTTTG	0.428													19	36					0	0	0	0	T	105924356	T	T	105924356	3	4	78	1	0	0	0	0	1	0	0	0	8033	217	8	5	782	5	KBTBD3	11	105924356	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	23362809	105924356	29082160	180	15707											
C11orf87	399947	broad.mit.edu	37	chr11	109294845	109294845	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccgtgccagggtccctgTgctcctccgcctccaccgcc	2	8	9	22	3	0	0	0	0	0	0	5	0	5	0	9	1	2	1	9	1	0	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:109294845T>G	uc001pkn.2	+	2	860	c.486T>G	c.(484-486)TGT>TGG	p.C162W	C11orf87_uc010rwb.1_5'Flank	NM_207645	NP_997528	Q6NUJ2	CK087_HUMAN	hypothetical protein LOC399947 precursor	162	Cytoplasmic (Potential).					integral to membrane				ovary(2)	2						AGGGTCCCTGTGCTCCTCCGC	0.672													7	40					0	0	0	0	G	109294845	G	G	109294845	3	3	78	1	0	0	0	0	1	0	0	0	1675	1702	59	5	488	5	C11orf87	11	109294845	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	3370489	109294845	25711671	181	15708											
MLL	4297	broad.mit.edu	37	chr11	118343463	118343463	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taatgataggagaagcagaaGgtattcagtgtcggagagaa	16	8	14	3	1	1	4	1	1	0	3	2	7	1	5	0	3	1	2	0	3	6	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:118343463G>A	uc001pta.2	+	3	1612	c.1589G>A	c.(1588-1590)AGG>AAG	p.R530K	MLL_uc001ptb.2_Missense_Mutation_p.R530K|MLL_uc001psz.1_Missense_Mutation_p.R563K|MLL_uc001ptd.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	530					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AGAAGCAGAAGGTATTCAGTG	0.498			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								13	85					0	0	0	0	A	118343463	A	A	118343463	3	1	78	1	0	0	0	0	1	0	0	0	9673	1000	35	4	1599	4	MLL	11	118343463	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	9048618	118343463	16663053	182	15709											
OR6X1	390260	broad.mit.edu	37	chr11	123625128	123625128	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgcctgcaagggttaatatGtaggtgagaaagattgcaat	13	12	12	4	0	0	2	0	1	0	2	0	3	0	2	1	2	3	4	1	2	6	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:123625128G>A	uc010rzy.1	-	1	99	c.99C>T	c.(97-99)TAC>TAT	p.Y33Y		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GGGTTAATATGTAGGTGAGAA	0.423													13	94					0	0	0	0	A	123625128	A	A	123625128	2	1	78	1	0	0	0	0	0	0	0	1	11266	1372	48	4		4	OR6X1	11	123625128	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	5281665	123625128	11381388	183	15710											
GLB1L3	112937	broad.mit.edu	37	chr11	134177072	134177072	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcggctggttcgacagatggGgagataagcaccatgttaaa	12	9	13	7	2	0	2	0	0	0	2	2	4	0	2	1	4	1	4	1	4	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr11:134177072G>A	uc009zdf.2	+	10	1291	c.931G>A	c.(931-933)GGA>AGA	p.G311R	GLB1L3_uc010scu.1_Missense_Mutation_p.G12R|GLB1L3_uc001qho.3_RNA	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	311					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CGACAGATGGGGAGATAAGCA	0.433													12	13					0	0	0	0	A	134177072	A	A	134177072	3	1	78	1	0	0	0	0	1	0	0	0	6467	1233	43	4	969	4	GLB1L3	11	134177072	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	10551944	134177072	829444	184	15711											
FGF6	2251	broad.mit.edu	37	chr12	4554546	4554546	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cggcaatctctccagctagcCcggcgcgagacctggacagc	8	5	12	16	4	1	1	0	0	1	1	3	3	2	2	3	3	3	2	3	3	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:4554546C>A	uc001qmr.1	-	1	235	c.191G>T	c.(190-192)GGG>GTG	p.G64V		NM_020996	NP_066276	P10767	FGF6_HUMAN	fibroblast growth factor 6 precursor	64					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			lung(2)|ovary(1)	3			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			TCCAGCTAGCCCGGCGCGAGA	0.647													21	79					1.77063e-15	2.3266e-15	1	0	A	4554546	A	A	4554546	3	1	78	1	0	0	0	0	1	0	0	0	5888	623	22	4	447	4	FGF6	12	4554546	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08		4554546	129297349	185	15712											
KCNA5	3741	broad.mit.edu	37	chr12	5154798	5154798	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcactgttgggggcaagatCgtgggctcgctgtgtgccat	6	11	15	9	2	1	1	1	0	0	1	3	1	1	1	1	3	1	4	1	3	1	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:5154798C>T	uc001qni.2	+	1	1714	c.1485C>T	c.(1483-1485)ATC>ATT	p.I495I		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	495	Helical; Name=Segment S6; (Potential).					Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						GGGGCAAGATCGTGGGCTCGC	0.602													25	79					0	0	0	0	T	5154798	T	T	5154798	2	4	78	1	0	0	0	0	0	0	0	1	8045	874	31	1		1	KCNA5	12	5154798	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	600252	5154798	128697097	186	15713											
RERGL	79785	broad.mit.edu	37	chr12	18234236	18234236	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtttatcaggatgtccttGataattctgataaacatcat	14	15	6	6	0	3	2	2	2	1	0	4	3	4	3	1	1	1	1	1	1	5	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:18234236G>A	uc001rdq.2	-	6	701	c.507C>T	c.(505-507)ATC>ATT	p.I169I	RERGL_uc001rdr.2_Silent_p.I168I	NM_024730	NP_079006	Q9H628	RERGL_HUMAN	RERG/RAS-like	169	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity				0						GGATGTCCTTGATAATTCTGA	0.408													21	61					0	0	0	0	A	18234236	A	A	18234236	2	1	78	1	0	0	0	0	0	0	0	1	13298	1280	45	2		2	RERGL	12	18234236	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	13079438	18234236	115617659	187	15714											
SLCO1B1	10599	broad.mit.edu	37	chr12	21350088	21350088	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcaaacagctaatttgacCaatcaaggaaaaaatattac	20	9	5	7	0	2	1	2	1	0	0	2	3	2	2	1	1	3	1	1	1	9	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:21350088C>A	uc001req.3	+	8	1040	c.936C>A	c.(934-936)ACC>ACA	p.T312T		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	312	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CTAATTTGACCAATCAAGGAA	0.323													15	39					3.45872e-05	3.71957e-05	1	0	A	21350088	A	A	21350088	2	1	78	1	0	0	0	0	0	0	0	1	14787	581	21	4		4	SLCO1B1	12	21350088	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	3115852	21350088	112501807	188	15715											
BICD1	636	broad.mit.edu	37	chr12	32458869	32458869	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agtagatggactcaaatttgCcgaggatgggagtgaaccaa	14	8	13	6	1	1	2	1	1	0	1	1	6	1	5	2	3	2	1	2	3	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:32458869C>T	uc001rku.2	+	4	899	c.818C>T	c.(817-819)GCC>GTC	p.A273V	BICD1_uc001rkv.2_Missense_Mutation_p.A273V|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	273					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CTCAAATTTGCCGAGGATGGG	0.448													4	39					0	0	0	0	T	32458869	T	T	32458869	3	4	78	1	0	0	0	0	1	0	0	0	1431	739	26	4	832	4	BICD1	12	32458869	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	11108781	32458869	101393026	189	15716											
SLC2A13	114134	broad.mit.edu	37	chr12	40223995	40223995	+	Frame_Shift_Del	DEL	C	-	-																															tgttcatcttgtagcagaaaCcgcagtctggatccaacata																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:40223995delC	uc010skm.1	-	7	1406	c.1355delG	c.(1354-1356)GGTfs	p.G452fs	C12orf40_uc009zjv.1_Intron|SLC2A13_uc001rme.1_Frame_Shift_Del_p.G99fs	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	452	Extracellular (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				GTAGCAGAAACCGCAGTCTGG	0.418										HNSCC(50;0.14)			---	---	---								-	40223995	-	-	40223995	7	5	78	1	0	1	0	1	0	0	0	0	14606	507	18	0	607	0	SLC2A13	12	40223995	Frame_Shift_Del	DEL	C	TCGA-CN-6021-01A-11D-1683-08	7765126	40223995	93627900	190	15717											
MLL2	8085	broad.mit.edu	37	chr12	49444035	49444045	+	Frame_Shift_Del	DEL	CAGGGCTGGGG	-	-																															cctaggccagagaagtcatcCagggctggggcagggctggg																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:49444035_49444045delCAGGGCTGGGG	uc001rta.3	-	11	3326_3336	c.3326_3336delCCCCAGCCCTG	c.(3325-3336)GCCCCAGCCCTGfs	p.A1109fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1109_1112	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGAAGTCATCCAGGGCTGGGGCAGGGCTGGG	0.616			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								-	49444045	-	-	49444035	7	5	78	1	0	1	0	1	0	0	0	0	9674	581	21	0	13453	0	MLL2	12	49444035	Frame_Shift_Del	DEL	CAGGGCTGGGG	TCGA-CN-6021-01A-11D-1683-08	9220040	49444035	84407860	191	15718											
KRT1	3848	broad.mit.edu	37	chr12	53072487	53072487	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggaggtatctacctgctgCagcagctcccattttgtttg	6	14	11	10	0	1	0	0	0	1	0	2	1	2	1	2	2	5	6	2	2	2	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:53072487C>T	uc001sau.1	-	2	704	c.645G>A	c.(643-645)CTG>CTA	p.L215L	KRT1_uc001sav.1_Silent_p.L215L	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	215	Coil 1A.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						CTACCTGCTGCAGCAGCTCCC	0.463													25	51					0	0	0	0	T	53072487	T	T	53072487	2	4	78	1	0	0	0	0	0	0	0	1	8486	697	25	4		4	KRT1	12	53072487	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	3628452	53072487	80779408	192	15719											
KRT18	3875	broad.mit.edu	37	chr12	53343350	53343350	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactggagccattacttcaaGatcatcgaggacctgagggc	11	8	12	10	1	2	2	2	1	0	1	3	6	2	4	2	3	2	0	2	3	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:53343350G>A	uc001sbe.2	+	2	462	c.393G>A	c.(391-393)AAG>AAA	p.K131K	KRT18_uc009zmn.1_Silent_p.K131K|KRT18_uc001sbf.1_5'UTR|KRT18_uc001sbg.2_Silent_p.K131K|KRT18_uc009zmo.2_Silent_p.K131K|KRT8_uc009zml.1_Intron|KRT8_uc009zmm.1_5'UTR	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	131	Rod.|Linker 1.|Necessary for interaction with PNN.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						ATTACTTCAAGATCATCGAGG	0.557													9	29					0	0	0	0	A	53343350	A	A	53343350	2	1	78	1	0	0	0	0	0	0	0	1	8494	933	33	2		2	KRT18	12	53343350	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	270863	53343350	80508545	193	15720											
OR6C3	254786	broad.mit.edu	37	chr12	55726162	55726162	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaccattttgagaatcccGtctgccagtcaaagaaaaaa	16	8	8	9	1	2	2	1	1	1	2	3	4	3	3	3	1	1	0	3	1	5	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:55726162G>T	uc010spj.1	+	1	678	c.678G>T	c.(676-678)CCG>CCT	p.P226P		NM_054104	NP_473445	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGAGAATCCCGTCTGCCAGTC	0.348													41	67					1.22674e-20	1.69282e-20	1	0	T	55726162	T	T	55726162	2	4	78	1	0	0	0	0	0	0	0	1	11246	1132	40	3		3	OR6C3	12	55726162	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2382812	55726162	78125733	194	15721											
TSPAN8	7103	broad.mit.edu	37	chr12	71523125	71523125	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtacctcaataactgccaGtccaaatgatattccaataa	15	11	4	11	0	1	1	1	1	0	0	3	1	3	1	4	0	3	1	4	0	7	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:71523125G>T	uc009zrt.1	-	7	808	c.646C>A	c.(646-648)CTG>ATG	p.L216M	TSPAN8_uc001swk.1_Missense_Mutation_p.L216M|TSPAN8_uc001swj.1_Missense_Mutation_p.L216M	NM_004616	NP_004607	P19075	TSN8_HUMAN	transmembrane 4 superfamily member 3	216	Helical; (Potential).				protein glycosylation	integral to membrane|lysosome	signal transducer activity			skin(2)|lung(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			ATAACTGCCAGTCCAAATGAT	0.274													3	21					1.23904e-05	1.34375e-05	1	0	T	71523125	T	T	71523125	3	4	78	1	0	0	0	0	1	0	0	0	16720	1020	36	4	75	4	TSPAN8	12	71523125	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	15796963	71523125	62328770	195	15722											
NAV3	89795	broad.mit.edu	37	chr12	78444759	78444759	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgaggttcatgtataccaCgcctctccgtcgagctgctg	6	11	10	14	4	2	0	1	0	1	0	5	2	2	0	3	1	3	4	3	1	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:78444759C>T	uc001syp.2	+	11	2521	c.2348C>T	c.(2347-2349)ACG>ATG	p.T783M	NAV3_uc001syo.2_Missense_Mutation_p.T783M|NAV3_uc010sub.1_Missense_Mutation_p.T283M	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	783						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ATGTATACCACGCCTCTCCGT	0.552										HNSCC(70;0.22)			10	30					0	0	0	0	T	78444759	T	T	78444759	3	4	78	1	0	0	0	0	1	0	0	0	10238	536	19	1	2390	1	NAV3	12	78444759	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	6921634	78444759	55407136	196	15723											
TMTC2	160335	broad.mit.edu	37	chr12	83290168	83290168	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cataccctttgttcctgccaCgaacctgtttttctatgtcg	6	16	6	13	2	1	0	0	0	1	0	3	1	2	0	4	0	3	2	4	0	3	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:83290168C>G	uc001szt.2	+	3	1658	c.1226C>G	c.(1225-1227)ACG>AGG	p.T409R	TMTC2_uc001szr.1_Missense_Mutation_p.T409R|TMTC2_uc001szs.1_Missense_Mutation_p.T409R|TMTC2_uc010suk.1_Missense_Mutation_p.T164R	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	409	Helical; (Potential).					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						GTTCCTGCCACGAACCTGTTT	0.418													10	121					0	0	0	0	G	83290168	G	G	83290168	3	3	78	1	0	0	0	0	1	0	0	0	16327	536	19	3	1236	3	TMTC2	12	83290168	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	4845409	83290168	50561727	197	15724											
BTG1	694	broad.mit.edu	37	chr12	92538007	92538007	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaggcttcatacagcacaCagatggagccatcctctcca	11	8	9	13	0	2	2	1	1	1	1	4	3	3	3	3	2	3	2	3	2	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:92538007C>A	uc001tby.3	-	2	727	c.365G>T	c.(364-366)TGT>TTT	p.C122F	BTG1_uc001tbv.1_5'Flank|BTG1_uc001tbw.1_5'Flank|BTG1_uc001tbx.1_5'Flank|BTG1_uc009zss.1_5'Flank|uc001tca.2_5'Flank	NM_001731	NP_001722	P62324	BTG1_HUMAN	B-cell translocation protein 1	122					cell migration|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of endothelial cell differentiation|positive regulation of myoblast differentiation|regulation of apoptosis|regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|transcription cofactor activity				0		Acute lymphoblastic leukemia(6;3.02e-13)|all_hematologic(6;4.32e-09)				ATACAGCACACAGATGGAGCC	0.512			T	MYC	BCLL						OREG0022024	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	71					4.26978e-12	5.38972e-12	1	0	A	92538007	A	A	92538007	3	1	78	1	0	0	0	0	1	0	0	0	1558	478	17	4	154	4	BTG1	12	92538007	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	9247839	92538007	41313888	198	15725											
ANKS1B	56899	broad.mit.edu	37	chr12	99640640	99640640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcatcctgtcgggagaggtCatctgcaaaaggaaggaagg	12	7	15	7	1	3	1	2	0	1	1	5	4	4	3	1	5	1	1	1	5	4	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:99640640C>T	uc001tge.1	-	13	2176	c.1759G>A	c.(1759-1761)GAC>AAC	p.D587N	ANKS1B_uc001tgf.1_Missense_Mutation_p.D167N|ANKS1B_uc001tgk.2_5'UTR|ANKS1B_uc009ztt.1_Missense_Mutation_p.D553N	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	587						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CGGGAGAGGTCATCTGCAAAA	0.473													40	113					0	0	0	0	T	99640640	T	T	99640640	3	4	78	1	0	0	0	0	1	0	0	0	689	826	29	2	2331	2	ANKS1B	12	99640640	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	7102633	99640640	34211255	199	15726											
SLC17A8	246213	broad.mit.edu	37	chr12	100797842	100797842	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttgtcagcagtcccacaCatggttatgacaatcgttgt	9	13	8	11	1	2	1	1	1	1	0	4	1	3	1	1	1	1	3	1	1	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:100797842C>A	uc010svi.1	+	9	1393	c.1080C>A	c.(1078-1080)CAC>CAA	p.H360Q	SLC17A8_uc009ztx.2_Missense_Mutation_p.H310Q	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	360	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						CAGTCCCACACATGGTTATGA	0.433													17	45					2.39187e-15	3.1216e-15	1	0	A	100797842	A	A	100797842	3	1	78	1	0	0	0	0	1	0	0	0	14488	477	17	4	1114	4	SLC17A8	12	100797842	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	1157202	100797842	33054053	200	15727											
TMEM116	89894	broad.mit.edu	37	chr12	112374541	112374541	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagctgcccaggaaaatggcGataccataaaaataaagtgt	18	7	9	7	1	0	0	0	0	0	0	0	2	0	1	2	2	3	1	2	2	9	3	rs143338734		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:112374541G>A	uc001ttc.1	-	10	923	c.267C>T	c.(265-267)ATC>ATT	p.I89I	TMEM116_uc001ttd.1_Silent_p.I181I|TMEM116_uc001tte.1_Silent_p.I146I|TMEM116_uc001ttf.1_Silent_p.I89I|TMEM116_uc001ttg.1_Intron|TMEM116_uc001tth.1_Intron|TMEM116_uc001tti.1_Silent_p.I181I	NM_138341	NP_612350	Q8NCL8	TM116_HUMAN	transmembrane protein 116	89	Helical; (Potential).					integral to membrane				ovary(1)	1						GGAAAATGGCGATACCATAAA	0.473													20	59					0	0	0	0	A	112374541	A	A	112374541	2	1	78	1	0	0	0	0	0	0	0	1	16096	1048	37	1		1	TMEM116	12	112374541	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	11576699	112374541	21477354	201	15728											
PITPNM2	57605	broad.mit.edu	37	chr12	123489976	123489976	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgaactgggccatcttacGggaaagcatgagctgtgcct	10	10	12	9	1	1	2	0	2	1	0	1	3	1	3	2	2	5	2	2	2	3	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr12:123489976G>C	uc001uej.1	-	6	902	c.763C>G	c.(763-765)CGT>GGT	p.R255G	PITPNM2_uc001uek.1_Missense_Mutation_p.R255G|PITPNM2_uc009zxu.1_Missense_Mutation_p.R255G	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	255					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GCCATCTTACGGGAAAGCATG	0.637													39	113					0	0	0	0	C	123489976	C	C	123489976	3	2	78	1	0	0	0	0	1	0	0	0	12006	1116	39	3	3366	3	PITPNM2	12	123489976	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	11115435	123489976	10361919	202	15729											
RNF17	56163	broad.mit.edu	37	chr13	25451323	25451323	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaactctatgctgtgtccaTggtaagtgtctcaagtagcc	10	12	9	10	0	2	0	1	0	2	0	4	0	3	0	2	1	3	3	2	1	5	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr13:25451323T>C	uc001upr.2	+	34	4813	c.4772T>C	c.(4771-4773)ATG>ACG	p.M1591T	RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.M1587T|RNF17_uc001ups.2_Missense_Mutation_p.M1530T|RNF17_uc010aac.2_Missense_Mutation_p.M783T|RNF17_uc010aad.2_Missense_Mutation_p.M601T	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1591					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GCTGTGTCCATGGTAAGTGTC	0.413													15	17					0	0	0	0	C	25451323	C	C	25451323	3	2	78	1	0	0	0	0	1	0	0	0	13526	1478	51	5	4906	5	RNF17	13	25451323	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08		25451323	89718555	203	15730											
GPR12	2835	broad.mit.edu	37	chr13	27333487	27333487	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccagagcatgacgagcaTgacataggtaaacgtgaccg	13	5	11	12	3	0	4	0	3	0	1	0	5	0	4	3	1	3	3	3	1	3	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr13:27333487T>A	uc010aal.2	-	2	700	c.478A>T	c.(478-480)ATG>TTG	p.M160L	GPR12_uc010tdl.1_Missense_Mutation_p.M1L	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	160	Helical; Name=4; (Potential).					integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		ATGACGAGCATGACATAGGTA	0.592													14	17					0	0	0	0	A	27333487	A	A	27333487	3	1	78	1	0	0	0	0	1	0	0	0	6673	1464	51	5	530	5	GPR12	13	27333487	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	1882164	27333487	87836391	204	15731											
ATP7B	540	broad.mit.edu	37	chr13	52549007	52549007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctcgaagcccatgtcccCaatttgatggcaaacctgtt	9	10	9	13	1	0	1	0	1	0	0	2	2	1	1	5	2	2	2	5	2	3	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr13:52549007C>T	uc001vfw.2	-	2	506	c.349G>A	c.(349-351)GGG>AGG	p.G117R	ATP7B_uc010adv.2_Missense_Mutation_p.G117R|ATP7B_uc001vfx.2_Missense_Mutation_p.G117R|ATP7B_uc001vfy.2_Missense_Mutation_p.G117R|ATP7B_uc010tgt.1_Missense_Mutation_p.G117R|ATP7B_uc010tgu.1_Missense_Mutation_p.G117R|ATP7B_uc010tgv.1_Missense_Mutation_p.G117R|ATP7B_uc010tgw.1_Missense_Mutation_p.G85R	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	117	HMA 1.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CCCATGTCCCCAATTTGATGG	0.562									Wilson_disease				32	50					0	0	0	0	T	52549007	T	T	52549007	3	4	78	1	0	0	0	0	1	0	0	0	1193	594	21	4	4128	4	ATP7B	13	52549007	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	25215520	52549007	62620871	205	15732											
DOCK9	23348	broad.mit.edu	37	chr13	99449735	99449735	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgcatatgctagtgggccAgcattgacctagacaaagag	12	7	12	10	2	0	3	0	1	0	2	0	3	0	3	2	1	2	3	2	1	4	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr13:99449735A>G	uc001vnt.2	-	53	6025	c.5970T>C	c.(5968-5970)GCT>GCC	p.A1990A	DOCK9_uc001vnw.2_Silent_p.A1989A|DOCK9_uc001vnq.2_Silent_p.A537A|DOCK9_uc001vnr.2_Silent_p.A619A|DOCK9_uc010tin.1_Silent_p.A608A|DOCK9_uc001vns.2_Silent_p.A525A|DOCK9_uc010tio.1_Silent_p.A645A|DOCK9_uc010tip.1_Silent_p.A686A	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1990	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CTAGTGGGCCAGCATTGACCT	0.423													7	8					0	0	0	0	G	99449735	G	G	99449735	2	3	78	1	0	0	0	0	0	0	0	1	4716	175	7	5		5	DOCK9	13	99449735	Silent	SNP	A	TCGA-CN-6021-01A-11D-1683-08	46900728	99449735	15720143	206	15733											
C13orf28	122258	broad.mit.edu	37	chr13	113086835	113086835	+	Missense_Mutation	SNP	G	A	A																															aaaatattggaagatcttcaGgtagattggaaataatagat																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr13:113086835G>A	uc001vsd.1	+	6	554	c.523G>A	c.(523-525)GGA>AGA	p.G175R		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor	175						extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)					AAGATCTTCAGGTAGATTGGA	0.408													11	16					0	0	0	0	A	113086835	A	A	113086835	3	1	78	1	0	0	0	0	1	0	0	0	1730	1014	35	4	545	4	C13orf28	13	113086835	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	13637100	113086835	2083043	207	15734	31	2									
C13orf28	122258	broad.mit.edu	37	chr13	113086837	113086837	+	Splice_Site	SNP	T	A	A																															aatattggaagatcttcaggTagattggaaataatagataa																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr13:113086837T>A	uc001vsd.1	+	6	554	c.523_splice	c.e6+2	p.G175_splice		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor							extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)					GATCTTCAGGTAGATTGGAAA	0.413													10	16					0	0	0	0	A	113086837	A	A	113086837	5	1	78	1	0	0	0	0	0	0	1	0	1730	1652	57	5	547	5	C13orf28	13	113086837	Splice_Site	SNP	T	TCGA-CN-6021-01A-11D-1683-08	2	113086837	2083041	208	15735	31	2									
MYH6	4624	broad.mit.edu	37	chr14	23855572	23855572	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttctgggcctcggcagcCatgcggttggcgtggctgag	3	10	17	11	3	1	1	0	1	1	0	2	1	1	1	2	5	3	4	2	5	0	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr14:23855572C>T	uc001wjv.2	-	33	4978	c.4911G>A	c.(4909-4911)ATG>ATA	p.M1637I		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1637	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCTCGGCAGCCATGCGGTTGG	0.607													8	79					0	0	0	0	T	23855572	T	T	23855572	3	4	78	1	0	0	0	0	1	0	0	0	10091	594	21	4	936	4	MYH6	14	23855572	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08		23855572	83493968	209	15736											
NYNRIN	57523	broad.mit.edu	37	chr14	24884560	24884560	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgatgaggagagccagggccCccagtcagggggtgacagcc	9	4	17	11	0	1	4	1	3	0	1	1	5	1	4	4	4	2	0	4	4	0	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr14:24884560C>G	uc001wpf.3	+	9	3923	c.3605C>G	c.(3604-3606)CCC>CGC	p.P1202R		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1202					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						AGCCAGGGCCCCCAGTCAGGG	0.622													33	146					0	0	0	0	G	24884560	G	G	24884560	3	3	78	1	0	0	0	0	1	0	0	0	10850	623	22	4	3635	4	NYNRIN	14	24884560	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	1028988	24884560	82464980	210	15737											
FOXA1	3169	broad.mit.edu	37	chr14	38061468	38061468	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtgatgagcgagatgtacGagtagggcggcttggcgtgc	7	9	19	6	4	0	3	0	2	0	1	0	5	0	3	0	4	3	3	0	4	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr14:38061468G>A	uc001wuf.2	-	2	833	c.521C>T	c.(520-522)TCG>TTG	p.S174L	FOXA1_uc010tpz.1_Missense_Mutation_p.S141L	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	174	Fork-head.				chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		CGAGATGTACGAGTAGGGCGG	0.512													27	166					0	0	0	0	A	38061468	A	A	38061468	3	1	78	1	0	0	0	0	1	0	0	0	6021	1059	37	1	901	1	FOXA1	14	38061468	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	13176908	38061468	69288072	211	15738											
SIP1	8487	broad.mit.edu	37	chr14	39597527	39597527	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atatctgagtaattggtttgGagaaagagactttactccag	13	13	10	5	0	1	3	0	1	1	2	2	5	2	3	1	2	1	2	1	2	4	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr14:39597527G>A	uc001wuq.2	+	7	630	c.608G>A	c.(607-609)GGA>GAA	p.G203E	SIP1_uc001wur.2_Missense_Mutation_p.G203E|SIP1_uc001wus.2_Missense_Mutation_p.G188E|SIP1_uc010amx.2_RNA	NM_003616	NP_003607	O14893	GEMI2_HUMAN	SMN-interacting protein 1 isoform alpha	203					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding				0	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0121)		AATTGGTTTGGAGAAAGAGAC	0.264													23	127					0	0	0	0	A	39597527	A	A	39597527	3	1	78	1	0	0	0	0	1	0	0	0	14392	1174	41	2	634	2	SIP1	14	39597527	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1536059	39597527	67752013	212	15739											
FSCB	84075	broad.mit.edu	37	chr14	44975557	44975557	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaatgaagttctgctgatatTtttctgcccaatttcttcat	10	18	5	8	0	4	2	1	2	3	0	4	2	4	2	1	0	2	2	1	0	4	6	rs140155770		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr14:44975557T>A	uc001wvn.2	-	1	943	c.634A>T	c.(634-636)AAT>TAT	p.N212Y		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	212						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CTGCTGATATTTTTCTGCCCA	0.403													34	100					0	0	0	0	A	44975557	A	A	44975557	3	1	78	1	0	0	0	0	1	0	0	0	6100	1841	64	5	1847	5	FSCB	14	44975557	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	5378030	44975557	62373983	213	15740											
ERO1L	30001	broad.mit.edu	37	chr14	53112872	53112872	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagtacattcaaactaacCttccaaatgcgttgaataat	15	13	4	9	1	2	1	2	1	0	0	3	1	3	1	2	0	4	2	2	0	6	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr14:53112872C>G	uc001wzv.2	-	15	1572	c.1346G>C	c.(1345-1347)AGA>ACA	p.R449T	ERO1L_uc001wzw.2_RNA|ERO1L_uc010aof.2_Intron	NM_014584	NP_055399	Q96HE7	ERO1A_HUMAN	ERO1-like precursor	449					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor				0	Breast(41;0.226)					TCAAACTAACCTTCCAAATGC	0.333													14	34					0	0	0	0	G	53112872	G	G	53112872	3	3	78	1	0	0	0	0	1	0	0	0	5263	695	24	4	68	4	ERO1L	14	53112872	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	8137315	53112872	54236668	214	15741											
SYNE2	23224	broad.mit.edu	37	chr14	64630217	64630217	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagagtccagcacccacaTgctcctcccgggccccctgc	6	5	9	21	2	0	1	0	0	0	1	3	1	3	1	6	1	3	3	6	1	0	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr14:64630217T>A	uc001xgm.2	+	89	16627	c.16397T>A	c.(16396-16398)ATG>AAG	p.M5466K	SYNE2_uc001xgl.2_Missense_Mutation_p.M5466K|SYNE2_uc010apy.2_Missense_Mutation_p.M1851K|SYNE2_uc001xgn.2_Missense_Mutation_p.M428K|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5466	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGCACCCACATGCTCCTCCCG	0.502													15	51					0	0	0	0	A	64630217	A	A	64630217	3	1	78	1	0	0	0	0	1	0	0	0	15512	1464	51	5	16747	5	SYNE2	14	64630217	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	11517345	64630217	42719323	215	15742											
FUT8	2530	broad.mit.edu	37	chr14	66208932	66208932	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccacaatcaaattgccatttAtgctcaccaaccccgaactg	13	9	4	15	1	2	0	2	0	0	0	2	1	2	0	5	0	4	1	5	0	5	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr14:66208932A>C	uc001xin.2	+	11	2729	c.1532A>C	c.(1531-1533)TAT>TCT	p.Y511S	FUT8_uc001xio.2_Missense_Mutation_p.Y511S|FUT8_uc010tsp.1_Missense_Mutation_p.Y348S|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.Y511S|FUT8_uc001xiq.2_Missense_Mutation_p.Y382S|FUT8_uc001xis.2_Missense_Mutation_p.Y105S	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	511	SH3.|Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		ATTGCCATTTATGCTCACCAA	0.433													38	77					0	0	0	0	C	66208932	C	C	66208932	3	2	78	1	0	0	0	0	1	0	0	0	6144	449	16	5	1665	5	FUT8	14	66208932	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	1578715	66208932	41140608	216	15743											
SERPINA4	5267	broad.mit.edu	37	chr14	95030105	95030105	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccctgggggcctgctcaCacagccgcagccagatcctt	6	9	10	16	1	1	1	1	0	0	1	3	1	3	1	5	2	3	2	5	2	0	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr14:95030105C>A	uc001ydk.2	+	2	352	c.286C>A	c.(286-288)CAC>AAC	p.H96N	SERPINA4_uc010avd.2_Missense_Mutation_p.H133N|SERPINA4_uc001ydl.2_Missense_Mutation_p.H96N	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	96					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		GGCCTGCTCACACAGCCGCAG	0.607													15	37					9.16793e-09	1.07284e-08	1	0	A	95030105	A	A	95030105	3	1	78	1	0	0	0	0	1	0	0	0	14156	478	17	4	288	4	SERPINA4	14	95030105	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	28821173	95030105	12319435	217	15744											
AQR	9716	broad.mit.edu	37	chr15	35224630	35224630	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaccagcgccttgtgggtagCagggcctgggaaaaacaaac	13	5	13	10	1	0	0	0	0	0	0	0	1	0	1	3	3	5	2	3	3	5	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr15:35224630C>T	uc001ziv.2	-	11	970	c.789G>A	c.(787-789)CTG>CTA	p.L263L		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	263						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TTGTGGGTAGCAGGGCCTGGG	0.418													18	31					0	0	0	0	T	35224630	T	T	35224630	2	4	78	1	0	0	0	0	0	0	0	1	835	697	25	4		4	AQR	15	35224630	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08		35224630	67306762	218	15745											
SPRED1	161742	broad.mit.edu	37	chr15	38643248	38643248	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caatcagacatgtcagctttCaagatgaggatgagattgtc	13	11	10	7	0	3	4	3	2	0	3	4	6	3	5	0	1	1	1	0	1	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr15:38643248C>T	uc001zka.3	+	7	1053	c.718C>T	c.(718-720)CAA>TAA	p.Q240*		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	240	KBD.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TGTCAGCTTTCAAGATGAGGA	0.328									Legius_syndrome				3	21					0	0	0	0	T	38643248	T	T	38643248	4	4	78	1	0	0	0	0	0	1	0	0	15158	827	29	2	744	2	SPRED1	15	38643248	Nonsense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	3418618	38643248	63888144	219	15746											
TGM5	9333	broad.mit.edu	37	chr15	43552359	43552359	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtaccgacccacggccgcCgtgggaggagcgcacaagct	9	3	15	14	5	0	0	0	0	0	0	0	3	0	2	4	4	3	3	4	4	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr15:43552359C>G	uc001zrd.1	-	3	335	c.327G>C	c.(325-327)ACG>ACC	p.T109T	TGM5_uc001zre.1_Intron	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	109			T -> M.		epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CCACGGCCGCCGTGGGAGGAG	0.612													10	100					0	0	0	0	G	43552359	G	G	43552359	2	3	78	1	0	0	0	0	0	0	0	1	15899	639	23	3		3	TGM5	15	43552359	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	4909111	43552359	58979033	220	15747											
FBN1	2200	broad.mit.edu	37	chr15	48807700	48807700	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggaccaactggcagtaaTcagtaacgtttactggcagc	12	8	11	10	2	1	0	1	0	0	0	1	1	1	1	1	3	5	5	1	3	4	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr15:48807700T>A	uc001zwx.1	-	12	1680	c.1352A>T	c.(1351-1353)GAT>GTT	p.D451V		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	451	EGF-like 6.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CTGGCAGTAATCAGTAACGTT	0.438													10	84					0	0	0	0	A	48807700	A	A	48807700	3	1	78	1	0	0	0	0	1	0	0	0	5734	1435	50	5	7483	5	FBN1	15	48807700	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	5255341	48807700	53723692	221	15748											
SV2B	9899	broad.mit.edu	37	chr15	91835755	91835755	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgattgcccttcgactgccAgagactcgagaacaggtcct	9	9	10	13	2	0	3	0	1	0	2	3	6	1	3	3	1	3	0	3	1	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr15:91835755A>G	uc002bqv.2	+	12	2416	c.2025A>G	c.(2023-2025)CCA>CCG	p.P675P	SV2B_uc010uqv.1_Silent_p.P524P|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	675	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TTCGACTGCCAGAGACTCGAG	0.507													8	60					0	0	0	0	G	91835755	G	G	91835755	2	3	78	1	0	0	0	0	0	0	0	1	15484	175	7	5		5	SV2B	15	91835755	Silent	SNP	A	TCGA-CN-6021-01A-11D-1683-08	43028055	91835755	10695637	222	15749											
MEFV	4210	broad.mit.edu	37	chr16	3293434	3293434	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccacccagtagccattctCtggcgacagagtcatgttcc	9	9	8	15	1	2	1	1	0	1	1	4	2	3	1	4	1	1	2	4	1	1	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr16:3293434C>A	uc002cun.1	-	10	2093	c.2053G>T	c.(2053-2055)GAG>TAG	p.E685*		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	685	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	TAGCCATTCTCTGGCGACAGA	0.552													50	113					1.4374e-25	2.06492e-25	1	0	A	3293434	A	A	3293434	4	1	78	1	0	0	0	0	0	1	0	0	9512	922	32	2	296	2	MEFV	16	3293434	Nonsense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08		3293434	87061319	223	15750											
CPPED1	55313	broad.mit.edu	37	chr16	12798612	12798612	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatggcatgctggcagtgcCgctgcctcgcgatgctcagc	5	8	14	14	4	1	0	1	0	0	0	2	2	1	0	2	2	5	5	2	2	0	0	rs118082950	by1000genomes	TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr16:12798612C>T	uc002dca.3	-	3	695	c.584G>A	c.(583-585)CGG>CAG	p.R195Q	CPPED1_uc002dcb.3_Intron|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	195							hydrolase activity|metal ion binding				0						CTGGCAGTGCCGCTGCCTCGC	0.602													26	42					0	0	0	0	T	12798612	T	T	12798612	3	4	78	1	0	0	0	0	1	0	0	0	3837	652	23	1	368	1	CPPED1	16	12798612	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	9505178	12798612	77556141	224	15751											
CNOT1	23019	broad.mit.edu	37	chr16	58608535	58608535	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcacaagcttgcagacaggCcaacattgtcgccaaagttt	12	9	9	11	1	0	1	0	0	0	1	1	1	0	1	2	1	4	4	2	1	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr16:58608535C>A	uc002env.2	-	16	2250	c.1957G>T	c.(1957-1959)GCC>TCC	p.A653S	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.A653S|CNOT1_uc002enx.2_Missense_Mutation_p.A653S|CNOT1_uc002enz.1_Missense_Mutation_p.A82S	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	653					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TGCAGACAGGCCAACATTGTC	0.418													23	64					6.36457e-07	7.14391e-07	1	0	A	58608535	A	A	58608535	3	1	78	1	0	0	0	0	1	0	0	0	3632	739	26	4	5531	4	CNOT1	16	58608535	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	45809923	58608535	31746218	225	15752											
TP53	7157	broad.mit.edu	37	chr17	7579494	7579495	+	Frame_Shift_Ins	INS	-	G	G																															ggagcagcctctggcattctINSgggagcttcatctggacctg																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr17:7579494_7579495insG	uc002gim.2	-	4	386_387	c.192_193insC	c.(190-195)CCCAGAfs	p.P64fs	TP53_uc002gig.1_Frame_Shift_Ins_p.P64fs|TP53_uc002gih.2_Frame_Shift_Ins_p.P64fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Ins_p.P64fs|TP53_uc010cni.1_Frame_Shift_Ins_p.P64fs|TP53_uc002gij.2_Frame_Shift_Ins_p.P64fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Ins_p.P25fs|TP53_uc010cnk.1_Frame_Shift_Ins_p.P79fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	64_65	Interaction with HRMT1L2.		R -> T (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R65*(8)|p.0?(7)|p.G59fs*23(3)|p.264_265insSSGNL(1)|p.D48fs*55(1)|p.R65_P71delRMPEAAP(1)|p.P13fs*18(1)|p.R65fs*38(1)|p.D57_A76del20(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGGCATTCTGGGAGCTTCAT	0.614		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								G	7579495	G	G	7579494	7	5	78	1	0	1	1	0	0	0	0	0	16448	1588	55	0	1109	0	TP53	17	7579494	Frame_Shift_Ins	INS	-	TCGA-CN-6021-01A-11D-1683-08		7579494	73615716	226	15753											
MYOCD	93649	broad.mit.edu	37	chr17	12618891	12618891	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacatttggatagtgacaaGgtaatttttgcaaatttctt	14	16	7	4	0	1	1	0	1	1	0	1	2	1	2	0	2	2	2	0	2	5	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr17:12618891G>A	uc002gnn.2	+	3	476	c.177G>A	c.(175-177)AAG>AAA	p.K59K	MYOCD_uc002gno.2_Silent_p.K59K	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	59					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ATAGTGACAAGGTAATTTTTG	0.408													12	46					0	0	0	0	A	12618891	A	A	12618891	2	1	78	1	0	0	0	0	0	0	0	1	10140	1014	35	4		4	MYOCD	17	12618891	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	5039397	12618891	68576319	227	15754											
KSR1	8844	broad.mit.edu	37	chr17	25932786	25932786	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagacgcggcatgagaacgtGgtgctcttcatgggggcctg	7	8	16	10	3	2	2	1	1	1	2	2	3	2	2	1	4	2	2	1	4	1	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr17:25932786G>T	uc010crg.2	+	15	2041	c.1596G>T	c.(1594-1596)GTG>GTT	p.V532V	KSR1_uc002gzj.1_RNA|KSR1_uc002gzm.2_Silent_p.V311V	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	667	Protein kinase.				Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		ATGAGAACGTGGTGCTCTTCA	0.597													4	7					0.00024832	0.000261211	1	0	T	25932786	T	T	25932786	2	4	78	1	0	0	0	0	0	0	0	1	8621	1335	47	4		4	KSR1	17	25932786	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	13313895	25932786	55262424	228	15755											
LHX1	3975	broad.mit.edu	37	chr17	35297814	35297814	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agagaacagccttcactcggGtgaggccccaattcctggct	9	8	11	13	1	1	2	1	1	0	1	3	3	2	2	4	3	2	1	4	3	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr17:35297814G>C	uc002hnh.1	+	2	1393	c.397_splice	c.e2+1	p.A133_splice	LHX1_uc010cux.1_Splice_Site_p.A41_splice	NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1						cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				CTTCACTCGGGTGAGGCCCCA	0.562													5	22					0	0	0	0	C	35297814	C	C	35297814	5	2	78	1	0	0	0	0	0	0	1	0	8811	1275	44	4	404	4	LHX1	17	35297814	Splice_Site	SNP	G	TCGA-CN-6021-01A-11D-1683-08	9365028	35297814	45897396	229	15756											
MED1	5469	broad.mit.edu	37	chr17	37564503	37564503	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccccatctggccgtccagtGggtcttcacccccagggcca	5	7	10	19	1	3	0	1	0	2	0	4	0	4	0	7	3	0	0	7	3	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr17:37564503G>T	uc002hrv.3	-	17	4183	c.3971C>A	c.(3970-3972)CCA>CAA	p.P1324Q	MED1_uc010wee.1_Missense_Mutation_p.P1152Q|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1324	Ser-rich.|Interaction with TP53.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GCCGTCCAGTGGGTCTTCACC	0.512										HNSCC(31;0.082)			34	84					4.62619e-21	6.4532e-21	1	0	T	37564503	T	T	37564503	3	4	78	1	0	0	0	0	1	0	0	0	9478	1348	47	4	778	4	MED1	17	37564503	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2266689	37564503	43630707	230	15757											
KRT24	192666	broad.mit.edu	37	chr17	38856487	38856487	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatctacctgcttgttgaacCgctcctcagcctctcggcgg	5	11	10	15	3	3	1	1	1	2	0	5	2	4	1	4	2	4	3	4	2	2	3	rs150081982		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr17:38856487C>G	uc002hvd.2	-	4	1061	c.1004G>C	c.(1003-1005)CGG>CCG	p.R335P		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	335	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				CTTGTTGAACCGCTCCTCAGC	0.547													37	98					0	0	0	0	G	38856487	G	G	38856487	3	3	78	1	0	0	0	0	1	0	0	0	8500	652	23	3	593	3	KRT24	17	38856487	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	1291984	38856487	42338723	231	15758											
KCNH4	23415	broad.mit.edu	37	chr17	40330942	40330942	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgcaggtcttctgcatgAcctcggtgcgaccgtagcct	6	10	12	13	3	2	1	0	1	2	0	3	2	2	1	3	2	5	4	3	2	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr17:40330942A>G	uc002hzb.2	-	2	512	c.179T>C	c.(178-180)GTC>GCC	p.V60A		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	60	Cytoplasmic (Potential).|PAS.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTTCTGCATGACCTCGGTGCG	0.637													16	34					0	0	0	0	G	40330942	G	G	40330942	3	3	78	1	0	0	0	0	1	0	0	0	8073	275	10	5	2934	5	KCNH4	17	40330942	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	1474455	40330942	40864268	232	15759											
AOC3	8639	broad.mit.edu	37	chr17	41003593	41003593	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgcgctttctgacccagcGgctggggccagggctggtgg	4	8	18	11	2	1	1	0	1	1	0	1	2	1	1	2	6	2	3	2	6	0	1	rs402680		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr17:41003593G>A	uc002ibv.2	+	1	393	c.233G>A	c.(232-234)CGG>CAG	p.R78Q		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	78	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	CTGACCCAGCGGCTGGGGCCA	0.657													25	118					0	0	0	0	A	41003593	A	A	41003593	3	1	78	1	0	0	0	0	1	0	0	0	728	1116	39	1	235	1	AOC3	17	41003593	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	672651	41003593	40191617	233	15760											
RNF213	57674	broad.mit.edu	37	chr17	78363670	78363670	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacacaccattgccctctggCagttcctgtctgctcataag	9	11	7	14	0	3	0	1	0	2	0	4	0	4	0	3	1	3	3	3	1	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr17:78363670C>G	uc002jyh.1	+	41	9680	c.9457C>G	c.(9457-9459)CAG>GAG	p.Q3153E	uc002jyi.1_Intron|RNF213_uc010dhx.1_Missense_Mutation_p.Q97E	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGCCCTCTGGCAGTTCCTGTC	0.537													27	46					0	0	0	0	G	78363670	G	G	78363670	3	3	78	1	0	0	0	0	1	0	0	0	13542	711	25	4	15815	4	RNF213	17	78363670	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	37360077	78363670	2831540	234	15761											
PTPRM	5797	broad.mit.edu	37	chr18	8380391	8380391	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctggattatcactgcacatCcgtagttatgctaaatgatg	11	13	8	9	1	1	1	1	1	0	0	2	2	2	2	2	1	2	4	2	1	5	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr18:8380391C>T	uc002knn.3	+	27	4348	c.3845C>T	c.(3844-3846)TCC>TTC	p.S1282F	PTPRM_uc010dkv.2_Missense_Mutation_p.S1295F|PTPRM_uc010wzl.1_Missense_Mutation_p.S1069F	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1282	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CACTGCACATCCGTAGTTATG	0.458													14	39					0	0	0	0	T	8380391	T	T	8380391	3	4	78	1	0	0	0	0	1	0	0	0	12871	855	30	2	3998	2	PTPRM	18	8380391	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08		8380391	69696857	235	15762											
POTEC	388468	broad.mit.edu	37	chr18	14542858	14542858	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcaccacttgcccatcttGctcctgagcgtcttcataaa	9	11	6	15	1	3	1	1	1	2	0	4	1	4	1	3	0	4	2	3	0	2	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr18:14542858G>C	uc010dln.2	-	1	742	c.288C>G	c.(286-288)AGC>AGG	p.S96R	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	96										skin(3)	3						TGCCCATCTTGCTCCTGAGCG	0.612													9	206					0	0	0	0	C	14542858	C	C	14542858	3	2	78	1	0	0	0	0	1	0	0	0	12317	1310	46	4	1384	4	POTEC	18	14542858	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	6162467	14542858	63534390	236	15763											
C18orf34	374864	broad.mit.edu	37	chr18	30554564	30554564	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agagtctgtctggaagttggCcagcctcatctggctgaaga	9	10	13	9	0	4	3	1	1	3	2	4	4	4	4	2	3	1	2	2	3	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr18:30554564C>A	uc002kxn.2	-	21	2612	c.2470G>T	c.(2470-2472)GCC>TCC	p.A824S	C18orf34_uc010xbq.1_RNA|C18orf34_uc010dme.1_Missense_Mutation_p.A288S|C18orf34_uc010xbr.1_Missense_Mutation_p.A848S|C18orf34_uc010dmf.1_Missense_Mutation_p.A144S|C18orf34_uc002kxo.2_Missense_Mutation_p.A786S|C18orf34_uc002kxp.2_Missense_Mutation_p.A824S	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	824										ovary(1)	1						TGGAAGTTGGCCAGCCTCATC	0.493													14	41					0.00316338	0.00323051	1	0	A	30554564	A	A	30554564	3	1	78	1	0	0	0	0	1	0	0	0	1911	739	26	4	141	4	C18orf34	18	30554564	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	16011706	30554564	47522684	237	15764											
NARS	4677	broad.mit.edu	37	chr18	55274528	55274528	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcttgaagagtgtggcaccaCcttctacttgtgtttgcact	7	14	10	10	0	1	2	0	1	1	1	1	2	1	2	2	1	2	4	2	1	2	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr18:55274528C>T	uc002lgs.2	-	9	1067	c.839G>A	c.(838-840)GGT>GAT	p.G280D	NARS_uc002lgt.2_Missense_Mutation_p.G279D|NARS_uc010xea.1_Missense_Mutation_p.G31D|NARS_uc010xeb.1_RNA|NARS_uc010xec.1_3'UTR|NARS_uc010xed.1_3'UTR	NM_004539	NP_004530	O43776	SYNC_HUMAN	asparaginyl-tRNA synthetase	280					asparaginyl-tRNA aminoacylation	cytosol|soluble fraction	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding				0		Colorectal(73;0.227)			L-Asparagine(DB00174)	TGTGGCACCACCTTCTACTTG	0.438													28	58					0	0	0	0	T	55274528	T	T	55274528	3	4	78	1	0	0	0	0	1	0	0	0	10223	507	18	4	831	4	NARS	18	55274528	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	24719964	55274528	22802720	238	15765											
ZNF532	55205	broad.mit.edu	37	chr18	56651435	56651435	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggcctctgctacacgtctCacgtctctctgtccaggcac	5	11	9	16	2	4	0	1	0	4	0	7	0	5	0	2	2	2	2	2	2	1	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr18:56651435C>G	uc002lho.2	+	11	4190	c.3643C>G	c.(3643-3645)CAC>GAC	p.H1215D	ZNF532_uc002lhp.2_Missense_Mutation_p.H1213D|ZNF532_uc010xeg.1_Missense_Mutation_p.H1213D|ZNF532_uc002lhr.2_Missense_Mutation_p.H1213D|ZNF532_uc002lhs.2_Missense_Mutation_p.H1213D|ZNF532_uc010xeh.1_Missense_Mutation_p.H303D	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1215	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						CTACACGTCTCACGTCTCTCT	0.527													7	58					0	0	0	0	G	56651435	G	G	56651435	3	3	78	1	0	0	0	0	1	0	0	0	18039	826	29	2	3673	2	ZNF532	18	56651435	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	1376907	56651435	21425813	239	15766											
CDH7	1005	broad.mit.edu	37	chr18	63511088	63511088	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacaagttacacgctacggaTagaagctgcaaataaagatg	18	7	9	7	2	0	2	0	0	0	2	0	3	0	3	0	1	5	4	0	1	9	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr18:63511088T>C	uc002ljz.2	+	7	1347	c.1022T>C	c.(1021-1023)ATA>ACA	p.I341T	CDH7_uc002lka.2_Missense_Mutation_p.I341T|CDH7_uc002lkb.2_Missense_Mutation_p.I341T	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	341	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				ACGCTACGGATAGAAGCTGCA	0.443													24	49					0	0	0	0	C	63511088	C	C	63511088	3	2	78	1	0	0	0	0	1	0	0	0	3130	1406	49	5	1044	5	CDH7	18	63511088	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	6859653	63511088	14566160	240	15767											
CDH19	28513	broad.mit.edu	37	chr18	64235938	64235938	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgtttccattgtctaaatCagatcttagctgcaaatgga	12	15	7	7	0	3	1	1	0	2	1	4	2	4	2	1	1	2	3	1	1	4	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr18:64235938C>G	uc002lkc.1	-	3	343	c.205G>C	c.(205-207)GAT>CAT	p.D69H	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.D69H|CDH19_uc002lkd.2_Missense_Mutation_p.D69H	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	69	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TTGTCTAAATCAGATCTTAGC	0.333													13	45					0	0	0	0	G	64235938	G	G	64235938	3	3	78	1	0	0	0	0	1	0	0	0	3119	826	29	2	2153	2	CDH19	18	64235938	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	724850	64235938	13841310	241	15768											
CD226	10666	broad.mit.edu	37	chr18	67531612	67531612	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacataaatatcctctcttgTatcatccatggattgattgg	11	15	7	8	0	2	1	1	1	1	0	5	3	4	2	2	2	0	1	2	2	4	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr18:67531612T>A	uc010dqo.2	-	6	1396	c.949A>T	c.(949-951)ACA>TCA	p.T317S	CD226_uc002lkm.3_Missense_Mutation_p.T317S	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	317	Cytoplasmic (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				TCCTCTCTTGTATCATCCATG	0.388													33	61					0	0	0	0	A	67531612	A	A	67531612	3	1	78	1	0	0	0	0	1	0	0	0	3001	1638	57	5	65	5	CD226	18	67531612	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	3295674	67531612	10545636	242	15769											
CBLN2	147381	broad.mit.edu	37	chr18	70209049	70209049	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacggctgacctggtcgaaaTagatggtcatggtgcggttg	8	10	16	7	3	1	2	1	1	0	1	2	4	1	2	1	5	1	2	1	5	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr18:70209049T>A	uc002lku.2	-	2	582	c.347A>T	c.(346-348)TAT>TTT	p.Y116F	CBLN2_uc002lkv.2_Missense_Mutation_p.Y116F	NM_182511	NP_872317	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	116	C1q.					integral to membrane					0		Esophageal squamous(42;0.131)				CTGGTCGAAATAGATGGTCAT	0.706													10	11					0	0	0	0	A	70209049	A	A	70209049	3	1	78	1	0	0	0	0	1	0	0	0	2717	1406	49	5	339	5	CBLN2	18	70209049	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	2677437	70209049	7868199	243	15770											
THEG	51298	broad.mit.edu	37	chr19	371226	371226	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagacatgggcatgctccaGaagttatcacgaatcttcgg	11	10	10	10	2	3	2	2	0	1	2	5	3	4	2	1	2	1	3	1	2	3	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:371226G>C	uc002lol.2	-	6	771	c.732C>G	c.(730-732)TTC>TTG	p.F244L	THEG_uc002lom.2_Missense_Mutation_p.F220L	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1	244					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCATGCTCCAGAAGTTATCAC	0.642													52	189					0	0	0	0	C	371226	C	C	371226	3	2	78	1	0	0	0	0	1	0	0	0	15923	933	33	2	419	2	THEG	19	371226	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08		371226	58757757	244	15771											
TMEM146	257062	broad.mit.edu	37	chr19	5778610	5778610	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agacggtctgccagttcaggGcctcagccacagccagggca	9	5	13	14	1	3	1	2	0	1	1	3	1	3	1	4	3	3	2	4	3	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:5778610G>T	uc002mda.2	+	22	2381	c.2320G>T	c.(2320-2322)GCC>TCC	p.A774S		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	774	Cytoplasmic (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCAGTTCAGGGCCTCAGCCAC	0.652													86	68					7.69131e-47	1.13454e-46	1	0	T	5778610	T	T	5778610	3	4	78	1	0	0	0	0	1	0	0	0	16126	1203	42	4	2406	4	TMEM146	19	5778610	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	5407384	5778610	53350373	245	15772											
ACER1	125981	broad.mit.edu	37	chr19	6306747	6306747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagtccttgtcatcacccCggatttccacgtagggcagc	8	9	10	14	2	2	0	2	0	0	0	4	1	4	1	4	2	2	3	4	2	1	3	rs144461069		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:6306747C>T	uc002mel.2	-	6	851	c.773G>A	c.(772-774)CGG>CAG	p.R258Q		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	258	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0						GTCATCACCCCGGATTTCCAC	0.577													14	61					0	0	0	0	T	6306747	T	T	6306747	3	4	78	1	0	0	0	0	1	0	0	0	138	652	23	1	25	1	ACER1	19	6306747	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	528137	6306747	52822236	246	15773											
C3	718	broad.mit.edu	37	chr19	6693060	6693060	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gatggcgatgaggttgacagCcagagagaagaccttgacca	13	6	14	8	1	0	6	0	3	0	3	0	9	0	6	3	2	1	1	3	2	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:6693060C>G	uc002mfm.2	-	26	3327	c.3265G>C	c.(3265-3267)GCT>CCT	p.A1089P	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1089					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		AGGTTGACAGCCAGAGAGAAG	0.587													28	177					0	0	0	0	G	6693060	G	G	6693060	3	3	78	1	0	0	0	0	1	0	0	0	2214	739	26	4	1790	4	C3	19	6693060	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	386313	6693060	52435923	247	15774											
CCL25	6370	broad.mit.edu	37	chr19	8122770	8122770	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatcccatcagcagcagtaaGaggaatgtctccctcctgat	12	9	8	12	0	2	2	1	1	1	1	5	3	4	3	3	1	2	3	3	1	3	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:8122770G>C	uc002mjd.2	+	4	411	c.411G>C	c.(409-411)AAG>AAC	p.K137N	CCL25_uc002mjc.3_Missense_Mutation_p.K136N|CCL25_uc010dvy.1_3'UTR	NM_005624	NP_005615	O15444	CCL25_HUMAN	small inducible cytokine A25 precursor	137					chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|hormone activity				0						gcagcagtaagaggaatgtct	0													45	57					0	0	0	0	C	8122770	C	C	8122770	3	2	78	1	0	0	0	0	1	0	0	0	2910	933	33	2	425	2	CCL25	19	8122770	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1429710	8122770	51006213	248	15775											
HNRNPM	4670	broad.mit.edu	37	chr19	8551028	8551029	+	Frame_Shift_Ins	INS	-	G	G																															tgggcctggagcgcatgggcINSgccaacagcctcgagcgcat																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:8551028_8551029insG	uc010dwe.2	+	14	1796_1797	c.1716_1717insG	c.(1714-1719)GGCGCCfs	p.G572fs	HNRNPM_uc010xke.1_Frame_Shift_Ins_p.G518fs|HNRNPM_uc010dwd.2_Frame_Shift_Ins_p.G533fs|HNRNPM_uc002mka.2_Frame_Shift_Ins_p.G437fs|HNRNPM_uc002mkb.1_5'Flank	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	572_573	27 X 6 AA repeats of [GEVSTPAN]-[ILMV]- [DE]-[RH]-[MLVI]-[GAV].				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						AGCGCATGGGCGCCAACAGCCT	0.713													---	---	---								G	8551029	G	G	8551028	7	5	78	1	0	1	1	0	0	0	0	0	7310	755	27	0	1770	0	HNRNPM	19	8551028	Frame_Shift_Ins	INS	-	TCGA-CN-6021-01A-11D-1683-08	428258	8551028	50577955	249	15776											
TRMT1	55621	broad.mit.edu	37	chr19	13221060	13221060	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgatgctgagcagcggcaCcacgaagcgctggtagcagt	9	6	15	11	3	0	2	0	2	0	0	0	3	0	2	1	2	5	7	1	2	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:13221060C>A	uc002mwj.2	-	7	1181	c.931G>T	c.(931-933)GTG>TTG	p.V311L	TRMT1_uc010xmy.1_5'Flank|TRMT1_uc002mwk.2_Missense_Mutation_p.V311L|TRMT1_uc002mwl.3_Missense_Mutation_p.V311L|TRMT1_uc010xmz.1_Missense_Mutation_p.V97L	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	311							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		AGCAGCGGCACCACGAAGCGC	0.652													21	20					1.50039e-11	1.8816e-11	1	0	A	13221060	A	A	13221060	3	1	78	1	0	0	0	0	1	0	0	0	16628	507	18	4	1088	4	TRMT1	19	13221060	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	4670032	13221060	45907923	250	15777											
SLC5A5	6528	broad.mit.edu	37	chr19	17986870	17986870	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgtgggcgggccccgccAggtgctcacgctggcccaga	4	6	16	15	3	1	1	1	0	0	1	1	1	1	1	4	4	1	3	4	4	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:17986870A>T	uc002nhr.3	+	5	1000	c.653A>T	c.(652-654)CAG>CTG	p.Q218L		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	218	Extracellular (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GGGCCCCGCCAGGTGCTCACG	0.577													25	106					0	0	0	0	T	17986870	T	T	17986870	3	4	78	1	0	0	0	0	1	0	0	0	14732	188	7	5	671	5	SLC5A5	19	17986870	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	4765810	17986870	41142113	251	15778											
ZNF626	199777	broad.mit.edu	37	chr19	20808036	20808036	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaattttcttatgtctagtaAggctacaagagtggttaaag	13	14	10	4	0	2	1	0	0	2	1	2	2	2	1	0	2	1	3	0	2	8	7			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:20808036A>T	uc002npb.1	-	4	797	c.647T>A	c.(646-648)CTT>CAT	p.L216H	ZNF626_uc002npc.1_Missense_Mutation_p.L140H	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	216	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATGTCTAGTAAGGCTACAAGA	0.388													31	35					0	0	0	0	T	20808036	T	T	20808036	3	4	78	1	0	0	0	0	1	0	0	0	18117	72	3	5	943	5	ZNF626	19	20808036	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	2821166	20808036	38320947	252	15779											
ZNF536	9745	broad.mit.edu	37	chr19	30934689	30934689	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggcccacgtgcccatgagcGgccagcccatgggcagtcag	8	4	14	15	2	1	1	1	1	0	0	1	1	1	1	4	3	3	1	4	3	0	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:30934689G>T	uc002nsu.1	+	2	358	c.220G>T	c.(220-222)GGC>TGC	p.G74C	ZNF536_uc010edd.1_Missense_Mutation_p.G74C	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCCCATGAGCGGCCAGCCCAT	0.682													30	47					9.65021e-13	1.23433e-12	1	0	T	30934689	T	T	30934689	3	4	78	1	0	0	0	0	1	0	0	0	18041	1116	39	3	222	3	ZNF536	19	30934689	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	10126653	30934689	28194294	253	15780											
ANKRD27	84079	broad.mit.edu	37	chr19	33110271	33110271	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gagtccacggagcgctgcggGgactgcacaggggcctgcag	7	4	18	12	3	0	0	0	0	0	0	1	3	1	2	2	5	4	3	2	5	0	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:33110271G>A	uc002ntn.1	-	20	2058	c.1902C>T	c.(1900-1902)TCC>TCT	p.S634S		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	634					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					AGCGCTGCGGGGACTGCACAG	0.602													20	52					0	0	0	0	A	33110271	A	A	33110271	2	1	78	1	0	0	0	0	0	0	0	1	655	1219	43	4		4	ANKRD27	19	33110271	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2175582	33110271	26018712	254	15781											
RHPN2	85415	broad.mit.edu	37	chr19	33517463	33517463	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcccctccagctcttccttGagcatctgcaggtctgagtt	6	12	9	14	0	3	2	0	2	3	0	5	2	5	2	4	1	4	4	4	1	0	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:33517463G>C	uc002nuf.2	-	3	327	c.261C>G	c.(259-261)CTC>CTG	p.L87L	RHPN2_uc010xro.1_5'UTR|RHPN2_uc002nue.2_5'UTR	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	87	REM.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					GCTCTTCCTTGAGCATCTGCA	0.547													4	262					0	0	0	0	C	33517463	C	C	33517463	2	2	78	1	0	0	0	0	0	0	0	1	13416	1277	45	2		2	RHPN2	19	33517463	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	407192	33517463	25611520	255	15782											
ARHGAP33	115703	broad.mit.edu	37	chr19	36278998	36278998	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aacctagctctagggcccagGggtccctcacctgcctcttc	6	9	9	17	0	3	0	1	0	2	0	5	0	4	0	5	3	3	1	5	3	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:36278998G>T	uc002obs.1	+	21	3133	c.3048G>T	c.(3046-3048)AGG>AGT	p.R1016S	ARHGAP33_uc002obt.1_Missense_Mutation_p.R1013S|ARHGAP33_uc010eel.2_Intron|ARHGAP33_uc002obv.1_Missense_Mutation_p.R765S	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	1177					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						TAGGGCCCAGGGGTCCCTCAC	0.672													42	47					6.2361e-21	8.63633e-21	1	0	T	36278998	T	T	36278998	3	4	78	1	0	0	0	0	1	0	0	0	882	1223	43	4	3613	4	ARHGAP33	19	36278998	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2761535	36278998	22849985	256	15783											
ZNF383	163087	broad.mit.edu	37	chr19	37733492	37733492	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgagtactccagttttggAgatgttttggaatatagaag	11	15	11	4	0	0	3	0	1	0	2	1	5	1	4	1	2	1	3	1	2	5	8			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:37733492A>T	uc002oft.1	+	8	934	c.354A>T	c.(352-354)GGA>GGT	p.G118G	ZNF383_uc002ofs.1_Silent_p.G53G|ZNF383_uc002ofu.1_Silent_p.G118G	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	118					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCAGTTTTGGAGATGTTTTGG	0.373													37	57					0	0	0	0	T	37733492	T	T	37733492	2	4	78	1	0	0	0	0	0	0	0	1	17941	291	11	5		5	ZNF383	19	37733492	Silent	SNP	A	TCGA-CN-6021-01A-11D-1683-08	1454494	37733492	21395491	257	15784											
ZNF235	9310	broad.mit.edu	37	chr19	44791701	44791701	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggccttaccacaagtgtcAcatttatatggtttctctcc	10	14	6	11	0	2	0	1	0	1	0	4	0	3	0	3	2	1	1	3	2	5	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:44791701A>G	uc002oza.3	-	5	1990	c.1887T>C	c.(1885-1887)TGT>TGC	p.C629C	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF235_uc002ozb.3_Silent_p.C625C|ZNF235_uc010xwx.1_Silent_p.C543C	NM_004234	NP_004225	Q14590	ZN235_HUMAN	zinc finger protein 93 homolog	629	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)	3		Prostate(69;0.0352)|all_neural(266;0.116)				CACAAGTGTCACATTTATATG	0.443													55	58					0	0	0	0	G	44791701	G	G	44791701	2	3	78	1	0	0	0	0	0	0	0	1	17855	157	6	5		5	ZNF235	19	44791701	Silent	SNP	A	TCGA-CN-6021-01A-11D-1683-08	7058209	44791701	14337282	258	15785											
ZNF808	388558	broad.mit.edu	37	chr19	53056767	53056767	+	Frame_Shift_Del	DEL	C	-	-																															cccaaagaatttcctgtaggCcccaaatccatatttctaat																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:53056767delC	uc010epq.1	+	5	775	c.598delC	c.(598-600)CCCfs	p.P200fs	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TTCCTGTAGGCCCCAAATCCA	0.378													---	---	---								-	53056767	-	-	53056767	7	5	78	1	0	1	0	1	0	0	0	0	18240	739	26	0	608	0	ZNF808	19	53056767	Frame_Shift_Del	DEL	C	TCGA-CN-6021-01A-11D-1683-08	8265066	53056767	6072216	259	15786											
ZNF808	388558	broad.mit.edu	37	chr19	53067395	53067395	+	RNA	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaaaagtaaaatcgtccgAtttcccagtggattcgaatg	14	10	8	9	3	0	0	0	0	0	0	4	3	2	1	3	1	0	1	3	1	5	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:53067395A>T	uc002pzq.2	+	4		c.3907A>T						Q8N4W9	ZN808_HUMAN	Homo sapiens zinc finger protein 808, mRNA (cDNA clone IMAGE:3542548), complete cds.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		AAATCGTCCGATTTCCCAGTG	0.428													27	38					0	0	0	0	T	53067395	T	T	53067395	1	4	78	0	1	0	0	0	0	0	0	0	18240	348	12	5		5	ZNF808	19	53067395	RNA	SNP	A	TCGA-CN-6021-01A-11D-1683-08	10628	53067395	6061588	260	15787											
NLRP12	91662	broad.mit.edu	37	chr19	54327405	54327405	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggacaggcgacagaggccGtccctgcctgcggttcgtag	6	7	16	12	4	0	1	0	0	0	1	2	3	1	2	3	4	2	2	3	4	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:54327405G>A	uc002qch.3	-	1	244	c.24C>T	c.(22-24)GAC>GAT	p.D8D	NLRP12_uc002qci.3_Silent_p.D8D|NLRP12_uc002qcj.3_Silent_p.D8D|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.D8D	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	8	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GACAGAGGCCGTCCCTGCCTG	0.612													15	61					0	0	0	0	A	54327405	A	A	54327405	2	1	78	1	0	0	0	0	0	0	0	1	10528	1136	40	1		1	NLRP12	19	54327405	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1260010	54327405	4801578	261	15788											
CACNG6	59285	broad.mit.edu	37	chr19	54515283	54515283	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagagtcagcccggagcctcCcccggccccacgcctcacct	6	4	10	21	3	2	1	2	0	0	1	3	3	3	2	8	2	2	0	8	2	0	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:54515283C>A	uc002qct.2	+	4	1213	c.623C>A	c.(622-624)CCC>CAC	p.P208H	CACNG6_uc002qcu.2_Missense_Mutation_p.P162H|CACNG6_uc002qcv.2_Missense_Mutation_p.P137H	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	208						voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		CCGGAGCCTCCCCCGGCCCCA	0.697													37	46					1.62957e-23	2.30656e-23	1	0	A	54515283	A	A	54515283	3	1	78	1	0	0	0	0	1	0	0	0	2573	623	22	4	637	4	CACNG6	19	54515283	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	187878	54515283	4613700	262	15789											
ZNF667	63934	broad.mit.edu	37	chr19	56953604	56953604	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttccgcactttctgcactGgcagacattcccaacaacat	10	12	5	14	1	1	1	0	0	1	1	3	1	3	1	2	1	3	3	2	1	2	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:56953604G>A	uc002qnd.2	-	5	922	c.760C>T	c.(760-762)CAG>TAG	p.Q254*	ZNF667_uc010etl.2_Nonsense_Mutation_p.Q36*|ZNF667_uc002qne.2_Nonsense_Mutation_p.Q254*|ZNF667_uc010etm.2_Nonsense_Mutation_p.Q197*	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	254	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TTTCTGCACTGGCAGACATTC	0.358													23	118					0	0	0	0	A	56953604	A	A	56953604	4	1	78	1	0	0	0	0	0	1	0	0	18141	1357	47	4	1076	4	ZNF667	19	56953604	Nonsense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2438321	56953604	2175379	263	15790											
USP29	57663	broad.mit.edu	37	chr19	57641701	57641701	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accacctcttcccttgagcaGtagtgcacctgttgggaaat	9	11	9	12	0	1	1	0	1	1	0	2	2	2	2	4	1	2	4	4	1	2	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:57641701G>T	uc002qny.2	+	4	2014	c.1658G>T	c.(1657-1659)AGT>ATT	p.S553I		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	553					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity	p.S553I(1)		lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCTTGAGCAGTAGTGCACCT	0.423													39	175					8.16277e-20	1.11839e-19	1	0	T	57641701	T	T	57641701	3	4	78	1	0	0	0	0	1	0	0	0	17127	1029	36	4	1660	4	USP29	19	57641701	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	688097	57641701	1487282	264	15791											
ZSCAN4	201516	broad.mit.edu	37	chr19	58187448	58187448	+	Translation_Start_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caccaactgttgaaacaaatCcctagagacacaaggcaaga	18	5	7	11	0	0	3	0	1	0	2	1	4	1	3	2	1	2	2	2	1	6	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr19:58187448C>G	uc002qpu.2	+	3	632	c.-65C>G	c.(-67--63)ATCCC>ATGCC			NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4						telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGAAACAAATCCCTAGAGACA	0.328													13	17					0	0	0	0	G	58187448	G	G	58187448	1	3	78	1	0	0	0	0	0	0	0	0	18304	870	30	2		2	ZSCAN4	19	58187448	Translation_Start_Site	SNP	C	TCGA-CN-6021-01A-11D-1683-08	545747	58187448	941535	265	15792											
FAM83C	128876	broad.mit.edu	37	chr20	33874604	33874604	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccagctccagccgtgcgagCagggcttgatatcgggagac	8	6	14	13	3	0	2	0	1	0	1	2	4	1	2	3	2	4	3	3	2	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr20:33874604C>T	uc010zux.1	-	4	2096	c.1978G>A	c.(1978-1980)GCT>ACT	p.A660T	EIF6_uc002xbv.1_5'Flank|EIF6_uc002xbx.1_5'Flank|EIF6_uc002xbz.1_5'Flank|EIF6_uc002xby.1_5'Flank|FAM83C_uc002xcb.1_Missense_Mutation_p.A315T	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	660										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GCCGTGCGAGCAGGGCTTGAT	0.627													12	37					0	0	0	0	T	33874604	T	T	33874604	3	4	78	1	0	0	0	0	1	0	0	0	5667	710	25	4	269	4	FAM83C	20	33874604	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08		33874604	29150916	266	15793											
CHD6	84181	broad.mit.edu	37	chr20	40068726	40068726	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcccaactttctccaggaaGcaaagtgctgggtctgctcg	9	10	10	12	1	2	0	0	0	2	0	5	1	3	1	2	2	4	3	2	2	3	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr20:40068726G>A	uc002xka.1	-	26	4099	c.3921C>T	c.(3919-3921)TGC>TGT	p.C1307C	CHD6_uc002xkb.1_Silent_p.C73C	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1307					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TCTCCAGGAAGCAAAGTGCTG	0.473													19	42					0	0	0	0	A	40068726	A	A	40068726	2	1	78	1	0	0	0	0	0	0	0	1	3344	963	34	4		4	CHD6	20	40068726	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	6194122	40068726	22956794	267	15794											
SGK2	10110	broad.mit.edu	37	chr20	42195737	42195737	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaatgggaacatcaacctGgggccttcagccaacccaaa	13	5	9	14	0	2	0	2	0	0	0	2	1	2	1	5	3	4	0	5	3	5	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr20:42195737G>A	uc002xkv.2	+	2	465	c.246G>A	c.(244-246)CTG>CTA	p.L82L	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Silent_p.L22L|SGK2_uc010ggm.2_Silent_p.L22L|SGK2_uc002xks.2_Silent_p.L22L|SGK2_uc002xku.2_Silent_p.L22L|SGK2_uc002xkq.1_Silent_p.L22L	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	82					intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACATCAACCTGGGGCCTTCAG	0.537													9	21					0	0	0	0	A	42195737	A	A	42195737	2	1	78	1	0	0	0	0	0	0	0	1	14274	1335	47	4		4	SGK2	20	42195737	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2127011	42195737	20829783	268	15795											
EYA2	2139	broad.mit.edu	37	chr20	45633631	45633631	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttccacagccatggcagcctAcggccagacgcagtacagtg	10	6	11	14	2	0	1	0	0	0	1	1	1	1	1	4	2	4	3	4	2	2	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr20:45633631A>T	uc002xsm.2	+	4	580	c.206A>T	c.(205-207)TAC>TTC	p.Y69F	EYA2_uc010ghp.2_Missense_Mutation_p.Y69F|EYA2_uc002xsn.2_Missense_Mutation_p.Y74F|EYA2_uc002xso.2_Missense_Mutation_p.Y69F|EYA2_uc002xsp.2_Missense_Mutation_p.Y69F|EYA2_uc002xsq.2_Missense_Mutation_p.Y69F	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	69					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				ATGGCAGCCTACGGCCAGACG	0.587													18	66					0	0	0	0	T	45633631	T	T	45633631	3	4	78	1	0	0	0	0	1	0	0	0	5354	391	14	5	216	5	EYA2	20	45633631	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	3437894	45633631	17391889	269	15796											
SLC17A9	63910	broad.mit.edu	37	chr20	61594048	61594048	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagcatcttctatttctcCggcggcctcaccttgctttg	5	14	8	14	2	4	1	1	0	3	1	5	1	4	1	3	2	2	2	3	2	1	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr20:61594048C>T	uc002yea.3	+	5	754	c.570C>T	c.(568-570)TCC>TCT	p.S190S	SLC17A9_uc002ydz.3_Silent_p.S184S|SLC17A9_uc011aap.1_Silent_p.S210S	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	190	Helical; (Potential).				exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						TCTATTTCTCCGGCGGCCTCA	0.637													44	83					0	0	0	0	T	61594048	T	T	61594048	2	4	78	1	0	0	0	0	0	0	0	1	14489	639	23	1		1	SLC17A9	20	61594048	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	15960417	61594048	1431472	270	15797											
NPBWR2	2832	broad.mit.edu	37	chr20	62737249	62737249	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agaaaggcgtagaggaagggGttcaggcacgagttggcgta	12	6	18	5	3	1	2	1	0	0	2	1	4	1	3	0	6	0	5	0	6	4	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr20:62737249G>A	uc011abt.1	-	1	936	c.936C>T	c.(934-936)AAC>AAT	p.N312N		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	312	Cytoplasmic (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					AGAGGAAGGGGTTCAGGCACG	0.517													18	39					0	0	0	0	A	62737249	A	A	62737249	2	1	78	1	0	0	0	0	0	0	0	1	10623	1252	44	4		4	NPBWR2	20	62737249	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1143201	62737249	288271	271	15798											
CHAF1B	8208	broad.mit.edu	37	chr21	37785298	37785298	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagccagttttgaacatgaGaactcctgatacagcaaaga	16	8	9	8	0	0	4	0	3	0	2	1	6	1	4	2	0	5	2	2	0	5	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr21:37785298G>T	uc002yvj.2	+	12	1316	c.1178G>T	c.(1177-1179)AGA>ATA	p.R393I		NM_005441	NP_005432	Q13112	CAF1B_HUMAN	chromatin assembly factor 1 subunit B	393					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			ovary(1)|skin(1)	2						TTGAACATGAGAACTCCTGAT	0.483													15	35					2.48551e-13	3.18973e-13	1	0	T	37785298	T	T	37785298	3	4	78	1	0	0	0	0	1	0	0	0	3327	942	33	2	1220	2	CHAF1B	21	37785298	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08		37785298	10344597	272	15799											
BACE2	25825	broad.mit.edu	37	chr21	42647329	42647329	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcagtgtctgaaatttcCgggcctttctcaacagagga	9	11	11	10	1	2	2	1	1	2	1	4	3	3	3	2	2	2	2	2	2	2	2	rs151128615		TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr21:42647329C>T	uc002yyw.2	+	9	1798	c.1335C>T	c.(1333-1335)TCC>TCT	p.S445S	BACE2_uc002yyx.2_Silent_p.S395S|BACE2_uc002yyy.2_Missense_Mutation_p.P389L|BACE2_uc010goo.2_RNA	NM_012105	NP_036237	Q9Y5Z0	BACE2_HUMAN	beta-site APP-cleaving enzyme 2 isoform A	445	Extracellular (Potential).				membrane protein ectodomain proteolysis|negative regulation of amyloid precursor protein biosynthetic process|peptide hormone processing	cell surface|endoplasmic reticulum|endosome|Golgi apparatus|integral to membrane	aspartic-type endopeptidase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0251)				CTGAAATTTCCGGGCCTTTCT	0.517													4	83					0	0	0	0	T	42647329	T	T	42647329	2	4	78	1	0	0	0	0	0	0	0	1	1284	652	23	1		1	BACE2	21	42647329	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	4862031	42647329	5482566	273	15800											
DIP2A	23181	broad.mit.edu	37	chr21	47985689	47985689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttacggggaggaggcgcttCatgccgaccacttcagtgcc	7	9	13	12	3	2	0	2	0	0	0	2	3	2	2	3	4	3	1	3	4	1	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr21:47985689C>T	uc002zjo.2	+	36	4411	c.4228C>T	c.(4228-4230)CAT>TAT	p.H1410Y	DIP2A_uc011afz.1_Missense_Mutation_p.H1406Y|DIP2A_uc002zjs.2_Missense_Mutation_p.H90Y|DIP2A_uc002zjt.2_RNA	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	1410					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GGAGGCGCTTCATGCCGACCA	0.582													10	54					0	0	0	0	T	47985689	T	T	47985689	3	4	78	1	0	0	0	0	1	0	0	0	4549	826	29	2	4483	2	DIP2A	21	47985689	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	5338360	47985689	144206	274	15801											
XKR3	150165	broad.mit.edu	37	chr22	17280839	17280839	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcgtgtttctctttgtgatGctaacttgagtctcttcctt	5	20	7	9	1	2	2	0	2	2	0	6	2	3	2	1	0	2	2	1	0	1	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr22:17280839G>A	uc002zlv.2	-	3	509	c.411C>T	c.(409-411)AGC>AGT	p.S137S	XKR3_uc011agf.1_Silent_p.S137S	NM_175878	NP_787074	Q5GH77	XKR3_HUMAN	X Kell blood group precursor-related family,	137						integral to membrane|plasma membrane				large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TCTTTGTGATGCTAACTTGAG	0.398													34	115					0	0	0	0	A	17280839	A	A	17280839	2	1	78	1	0	0	0	0	0	0	0	1	17500	1310	46	4		4	XKR3	22	17280839	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08		17280839	34023727	275	15802											
ZNF280A	129025	broad.mit.edu	37	chr22	22869807	22869807	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgaatttgaaatcatccCgacaaagagaacttcagcat	15	12	6	8	1	2	3	2	2	0	1	3	5	3	3	1	0	2	1	1	0	4	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chr22:22869807C>T	uc002zwe.2	-	2	401	c.148G>A	c.(148-150)GGG>AGG	p.G50R	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GAAATCATCCCGACAAAGAGA	0.423													4	77					0	0	0	0	T	22869807	T	T	22869807	3	4	78	1	0	0	0	0	1	0	0	0	17881	652	23	1	1484	1	ZNF280A	22	22869807	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	5588968	22869807	28434759	276	15803											
MXRA5	25878	broad.mit.edu	37	chrX	3228358	3228358	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtcccaccttcagggagAccagcctctccgtgtggcca	7	8	10	16	1	3	1	2	0	1	1	5	2	4	1	6	2	1	0	6	2	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:3228358A>C	uc004crg.3	-	7	8043	c.7886T>G	c.(7885-7887)GTC>GGC	p.V2629G		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2629	Ig-like C2-type 10.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTTCAGGGAGACCAGCCTCTC	0.612													12	37					0	0	0	0	C	3228358	C	C	3228358	3	2	78	1	0	0	0	0	1	0	0	0	10056	275	10	5	604	5	MXRA5	23	3228358	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08		3228358	152042202	277	15804											
MXRA5	25878	broad.mit.edu	37	chrX	3235195	3235195	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagcctccagaggatgcgcGgccaggggtcccccgaggcg	6	3	17	15	4	0	1	0	0	0	1	2	3	2	2	5	5	2	1	5	5	0	0			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:3235195G>T	uc004crg.3	-	6	6684	c.6527C>A	c.(6526-6528)CCG>CAG	p.P2176Q		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2176	Ig-like C2-type 6.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GAGGATGCGCGGCCAGGGGTC	0.677													5	7					8.12818e-05	8.6208e-05	1	0	T	3235195	T	T	3235195	3	4	78	1	0	0	0	0	1	0	0	0	10056	1116	39	3	1967	3	MXRA5	23	3235195	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	6837	3235195	152035365	278	15805											
GPR143	4935	broad.mit.edu	37	chrX	9707605	9707605	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggaagcagggttttcatggGgcatcagtggggatgggtga	8	9	19	5	1	2	1	2	1	0	0	2	3	2	3	0	7	1	3	0	7	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:9707605G>T	uc004cst.1	-	8	1100	c.1100C>A	c.(1099-1101)CCC>CAC	p.P367H		NM_000273	NP_000264	P51810	GP143_HUMAN	G protein-coupled receptor 143	347	Cytoplasmic (Potential).				calcium-mediated signaling using intracellular calcium source|eye pigment biosynthetic process|melanosome organization|melanosome transport|phosphatidylinositol-mediated signaling|regulation of calcium-mediated signaling|visual perception	apical plasma membrane|Golgi apparatus|integral to membrane|lysosomal membrane|melanosome membrane|membrane fraction	dopamine binding|L-DOPA receptor activity|protein binding|tyrosine binding			ovary(1)	1		Hepatocellular(5;0.000888)				GTTTTCATGGGGCATCAGTGG	0.582													9	18					0.000673444	0.00069511	1	0	T	9707605	T	T	9707605	3	4	78	1	0	0	0	0	1	0	0	0	6689	1232	43	4	182	4	GPR143	23	9707605	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	6472410	9707605	145562955	279	15806											
HCCS	3052	broad.mit.edu	37	chrX	11139818	11139818	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gattgattattatgatggtgGtgaagtcaacaaggactacc	13	12	11	5	0	1	3	1	3	0	0	1	5	1	4	1	3	2	0	1	3	6	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:11139818G>T	uc004cuk.2	+	7	961	c.695G>T	c.(694-696)GGT>GTT	p.G232V	HCCS_uc004cuj.2_Missense_Mutation_p.G232V|HCCS_uc004cul.1_Missense_Mutation_p.G232V	NM_005333	NP_005324	P53701	CCHL_HUMAN	holocytochrome c synthase	232					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding				0						TATGATGGTGGTGAAGTCAAC	0.448													30	90					1.1423e-28	1.64714e-28	1	0	T	11139818	T	T	11139818	3	4	78	1	0	0	0	0	1	0	0	0	7029	1261	44	4	717	4	HCCS	23	11139818	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1432213	11139818	144130742	280	15807											
PIR	8544	broad.mit.edu	37	chrX	15497928	15497928	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attcatcaaacagtaaaaacGgatccagattttttaactga	17	12	5	7	1	2	2	2	1	0	1	3	3	3	3	1	1	3	1	1	1	5	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:15497928G>T	uc004cwu.2	-	3	351	c.113C>A	c.(112-114)CCG>CAG	p.P38Q	PIR_uc004cwv.2_Missense_Mutation_p.P38Q|BMX_uc004cww.2_Intron	NM_003662	NP_003653	O00625	PIR_HUMAN	pirin	38					transcription from RNA polymerase II promoter	cytoplasm|nucleus	metal ion binding|protein binding|quercetin 2,3-dioxygenase activity|transcription cofactor activity			ovary(1)	1	Hepatocellular(33;0.183)					CAGTAAAAACGGATCCAGATT	0.343													9	35					7.48243e-07	8.37423e-07	1	0	T	15497928	T	T	15497928	3	4	78	1	0	0	0	0	1	0	0	0	11999	1116	39	3	791	3	PIR	23	15497928	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	4358110	15497928	139772632	281	15808											
BEND2	139105	broad.mit.edu	37	chrX	18220019	18220019	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttggataattcgctgtctCagtgctgtttttactgctgt	6	18	10	7	1	1	0	1	0	1	0	3	1	1	1	0	1	3	5	0	1	2	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:18220019C>T	uc004cyj.3	-	6	1103	c.949G>A	c.(949-951)GAG>AAG	p.E317K	BEND2_uc010nfb.2_Intron	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	317										ovary(3)|kidney(1)|central_nervous_system(1)	5						TTCGCTGTCTCAGTGCTGTTT	0.289													31	86					0	0	0	0	T	18220019	T	T	18220019	3	4	78	1	0	0	0	0	1	0	0	0	1400	835	29	2	1512	2	BEND2	23	18220019	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	2722091	18220019	137050541	282	15809											
PHKA2	5256	broad.mit.edu	37	chrX	18911701	18911701	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccataagccccactcggagCgctgtcataaaagaagtggc	12	6	10	13	2	1	1	1	0	0	1	2	2	1	2	3	2	2	1	3	2	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:18911701C>A	uc004cyv.3	-	33	4040	c.3610G>T	c.(3610-3612)GCT>TCT	p.A1204S	uc004cyt.2_Intron|PHKA2_uc004cyu.3_Missense_Mutation_p.A510S	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1204					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					CCACTCGGAGCGCTGTCATAA	0.522													59	164					3.39796e-24	4.84524e-24	1	0	A	18911701	A	A	18911701	3	1	78	1	0	0	0	0	1	0	0	0	11899	768	27	3	101	3	PHKA2	23	18911701	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	691682	18911701	136358859	283	15810											
KLHL34	257240	broad.mit.edu	37	chrX	21674708	21674708	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtccaagcgtggaagcgcGggtcgtaacggtgcacttgg	7	7	16	11	6	0	0	0	0	0	0	2	1	1	1	2	4	4	2	2	4	3	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:21674708G>T	uc004czz.1	-	1	1741	c.1199C>A	c.(1198-1200)CCG>CAG	p.P400Q		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	400	Kelch 2.									ovary(1)	1						GTGGAAGCGCGGGTCGTAACG	0.706													5	14					0.000602214	0.00062326	1	0	T	21674708	T	T	21674708	3	4	78	1	0	0	0	0	1	0	0	0	8426	1116	39	3	739	3	KLHL34	23	21674708	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	2763007	21674708	133595852	284	15811											
KLHL34	257240	broad.mit.edu	37	chrX	21675186	21675186	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggcgggcagcacgaggcCagagcccgagtacacgcgcc	8	1	16	16	6	0	1	0	0	0	1	0	3	0	1	4	3	3	3	4	3	1	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:21675186C>A	uc004czz.1	-	1	1263	c.721G>T	c.(721-723)GGC>TGC	p.G241C		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	241										ovary(1)	1						AGCACGAGGCCAGAGCCCGAG	0.677													9	25					9.70103e-10	1.17081e-09	1	0	A	21675186	A	A	21675186	3	1	78	1	0	0	0	0	1	0	0	0	8426	594	21	4	1217	4	KLHL34	23	21675186	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	478	21675186	133595374	285	15812											
SMS	6611	broad.mit.edu	37	chrX	21995233	21995233	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatactggcccaccgccgaCgggcgcctggttgaatatga	9	7	13	12	4	0	3	0	2	0	1	0	4	0	3	4	3	1	1	4	3	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:21995233C>A	uc004dag.2	+	5	485	c.384C>A	c.(382-384)GAC>GAA	p.D128E	SMS_uc011mjq.1_Missense_Mutation_p.D32E|SMS_uc004daf.1_Missense_Mutation_p.D75E|SMS_uc010nfs.2_5'Flank|SMS_uc010nft.2_5'Flank	NM_004595	NP_004586	P52788	SPSY_HUMAN	spermine synthase	128					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			ovary(1)	1					Spermine(DB00127)	CCACCGCCGACGGGCGCCTGG	0.428													27	60					7.41945e-09	8.73544e-09	1	0	A	21995233	A	A	21995233	3	1	78	1	0	0	0	0	1	0	0	0	14877	535	19	3	402	3	SMS	23	21995233	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	320047	21995233	133275327	286	15813											
MAGEB3	4114	broad.mit.edu	37	chrX	30254265	30254265	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actatccaccactacatctgTagatgtttcttacaaaaagt	14	13	4	10	0	2	1	0	0	2	1	3	1	3	1	2	0	2	2	2	0	6	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:30254265T>C	uc004dca.1	+	5	961	c.224T>C	c.(223-225)GTA>GCA	p.V75A		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	75											0						ACTACATCTGTAGATGTTTCT	0.458													12	20					0	0	0	0	C	30254265	C	C	30254265	3	2	78	1	0	0	0	0	1	0	0	0	9230	1638	57	5	226	5	MAGEB3	23	30254265	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	8259032	30254265	125016295	287	15814											
DMD	1756	broad.mit.edu	37	chrX	31165577	31165577	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttcaggaggggacggcagtgGggacaggcctttatgttcgt	7	10	17	7	2	1	0	1	0	0	0	2	3	1	3	1	7	0	2	1	7	1	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:31165577G>T	uc004dda.1	-	75	10856	c.10612C>A	c.(10612-10614)CCA>ACA	p.P3538T	DMD_uc004dcq.1_Missense_Mutation_p.P809T|DMD_uc004dcr.1_Missense_Mutation_p.P958T|DMD_uc004dcs.1_Missense_Mutation_p.P968T|DMD_uc004dct.1_Missense_Mutation_p.P1078T|DMD_uc004dcu.1_Missense_Mutation_p.P1078T|DMD_uc004dcv.1_Missense_Mutation_p.P1065T|DMD_uc004dcw.2_Missense_Mutation_p.P2194T|DMD_uc004dcx.2_Missense_Mutation_p.P2197T|DMD_uc004dcz.2_Missense_Mutation_p.P3415T|DMD_uc004dcy.1_Missense_Mutation_p.P3534T|DMD_uc004ddb.1_Missense_Mutation_p.P3530T|DMD_uc004dcm.1_Missense_Mutation_p.P470T|DMD_uc004dcn.1_Missense_Mutation_p.P457T|DMD_uc004dco.1_Missense_Mutation_p.P470T|DMD_uc004dcp.1_Missense_Mutation_p.P457T|DMD_uc011mkb.1_Missense_Mutation_p.P360T	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3538					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GACGGCAGTGGGGACAGGCCT	0.473													11	28					4.68919e-08	5.4052e-08	1	0	T	31165577	T	T	31165577	3	4	78	1	0	0	0	0	1	0	0	0	4602	1232	43	4	551	4	DMD	23	31165577	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	911312	31165577	124104983	288	15815											
NDP	4693	broad.mit.edu	37	chrX	43817843	43817843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtctgtatctcccattatcaCcagcagggagagcatagaaa	13	9	9	10	0	3	2	1	0	2	2	4	3	3	2	2	1	2	3	2	1	4	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:43817843C>T	uc004dga.3	-	2	628	c.49G>A	c.(49-51)GTG>ATG	p.V17M		NM_000266	NP_000257	Q00604	NDP_HUMAN	norrin precursor	17					canonical Wnt receptor signaling pathway|cell proliferation|cell-cell signaling|nervous system development|positive regulation of transcription, DNA-dependent|sensory perception of sound|vacuole organization|visual perception	extracellular matrix|extracellular space	cell surface binding|frizzled binding|growth factor activity|protein homodimerization activity				0						CCCATTATCACCAGCAGGGAG	0.458													18	24					0	0	0	0	T	43817843	T	T	43817843	3	4	78	1	0	0	0	0	1	0	0	0	10304	507	18	4	360	4	NDP	23	43817843	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	12652266	43817843	111452717	289	15816											
TSPYL2	64061	broad.mit.edu	37	chrX	53114157	53114157	+	Frame_Shift_Del	DEL	C	-	-																															ccggctggtgtctcactcaaCcccaatccgctggcaccggg																										TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:53114157delC	uc004drw.2	+	4	1151	c.1019delC	c.(1018-1020)ACCfs	p.T340fs	TSPYL2_uc004drv.2_3'UTR|TSPYL2_uc004drx.1_5'UTR	NM_022117	NP_071400	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	340				T->A: Impairs effect on cell proliferation; when associated with A-20.	cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding				0						TCTCACTCAACCCCAATCCGC	0.577													---	---	---								-	53114157	-	-	53114157	7	5	78	1	0	1	0	1	0	0	0	0	16727	507	18	0	1033	0	TSPYL2	23	53114157	Frame_Shift_Del	DEL	C	TCGA-CN-6021-01A-11D-1683-08	9296314	53114157	102156403	290	15817											
FAM123B	139285	broad.mit.edu	37	chrX	63412151	63412151	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggccatgctgtctgtcataCtgtccatgtcctgttctgct	5	15	9	12	0	3	0	1	0	2	0	5	0	5	0	3	1	3	3	3	1	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:63412151C>A	uc004dvo.2	-	2	1289	c.1016G>T	c.(1015-1017)AGT>ATT	p.S339I		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	339					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GTCTGTCATACTGTCCATGTC	0.537													86	119					4.869e-31	7.04724e-31	1	0	A	63412151	A	A	63412151	3	1	78	1	0	0	0	0	1	0	0	0	5451	565	20	4	2395	4	FAM123B	23	63412151	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	10297994	63412151	91858409	291	15818											
DLG3	1741	broad.mit.edu	37	chrX	69699025	69699025	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtcgctttgaatcgaagatAcatgacttacgagaacaaat	16	10	8	7	3	0	4	0	2	0	2	2	6	0	4	0	0	3	1	0	0	6	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:69699025A>T	uc004dyi.1	+	10	1759	c.1431A>T	c.(1429-1431)ATA>ATT	p.I477I	DLG3_uc004dyj.1_Silent_p.I140I|DLG3_uc011mpn.1_5'UTR	NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	477					axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)					AATCGAAGATACATGACTTAC	0.483													37	112					0	0	0	0	T	69699025	T	T	69699025	2	4	78	1	0	0	0	0	0	0	0	1	4578	381	14	5		5	DLG3	23	69699025	Silent	SNP	A	TCGA-CN-6021-01A-11D-1683-08	6286874	69699025	85571535	292	15819											
MAGEE1	57692	broad.mit.edu	37	chrX	75648802	75648802	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccaccgcctctgaggtacCgagcacctccctgccgccca	6	5	9	21	3	1	1	0	1	1	0	2	2	2	1	8	1	3	2	8	1	1	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:75648802C>T	uc004ecm.1	+	1	686	c.479C>T	c.(478-480)CCG>CTG	p.P160L		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	160	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						TCTGAGGTACCGAGCACCTCC	0.682													12	46					0	0	0	0	T	75648802	T	T	75648802	3	4	78	1	0	0	0	0	1	0	0	0	9238	652	23	1	481	1	MAGEE1	23	75648802	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	5949777	75648802	79621758	293	15820											
TBX22	50945	broad.mit.edu	37	chrX	79286015	79286015	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtggaagcagtggctcatCtccagtgacctctagtggag	9	9	14	9	0	3	1	1	1	2	0	4	3	3	3	2	4	1	2	2	4	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:79286015C>T	uc010nmg.1	+	9	1102	c.968C>T	c.(967-969)TCT>TTT	p.S323F	TBX22_uc004edi.1_Missense_Mutation_p.S203F|TBX22_uc004edj.1_Missense_Mutation_p.S323F	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	323					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						AGTGGCTCATCTCCAGTGACC	0.428													33	64					0	0	0	0	T	79286015	T	T	79286015	3	4	78	1	0	0	0	0	1	0	0	0	15724	913	32	2	998	2	TBX22	23	79286015	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	3637213	79286015	75984545	294	15821											
FAM46D	169966	broad.mit.edu	37	chrX	79698469	79698469	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaatgggcatgattgttGgagtcttatctccctttcaa	8	16	9	8	0	3	1	1	1	2	0	4	2	3	2	1	2	1	3	1	2	3	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:79698469G>T	uc004edl.1	+	5	765	c.431G>T	c.(430-432)TGG>TTG	p.W144L	FAM46D_uc004edm.1_Missense_Mutation_p.W144L	NM_152630	NP_689843	Q8NEK8	FA46D_HUMAN	hypothetical protein LOC169966	144										lung(2)	2						CATGATTGTTGGAGTCTTATC	0.368													48	100					2.6238e-40	3.85558e-40	1	0	T	79698469	T	T	79698469	3	4	78	1	0	0	0	0	1	0	0	0	5600	1357	47	4	433	4	FAM46D	23	79698469	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	412454	79698469	75572091	295	15822											
BRWD3	254065	broad.mit.edu	37	chrX	79947378	79947378	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gttcacattcttcgtctctgGaatgagccccccactctcct	6	13	6	16	1	4	1	1	1	3	0	7	2	4	2	4	1	1	1	4	1	1	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:79947378G>A	uc004edt.2	-	30	3688	c.3425C>T	c.(3424-3426)TCC>TTC	p.S1142F	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.S738F|BRWD3_uc004edp.2_Missense_Mutation_p.S971F|BRWD3_uc004edq.2_Missense_Mutation_p.S738F|BRWD3_uc010nmj.1_Missense_Mutation_p.S738F|BRWD3_uc004edr.2_Missense_Mutation_p.S812F|BRWD3_uc004eds.2_Missense_Mutation_p.S738F|BRWD3_uc004edu.2_Missense_Mutation_p.S812F|BRWD3_uc004edv.2_Missense_Mutation_p.S738F|BRWD3_uc004edw.2_Missense_Mutation_p.S738F|BRWD3_uc004edx.2_Missense_Mutation_p.S738F|BRWD3_uc004edy.2_Missense_Mutation_p.S738F|BRWD3_uc004edz.2_Missense_Mutation_p.S812F|BRWD3_uc004eea.2_Missense_Mutation_p.S812F|BRWD3_uc004eeb.2_Missense_Mutation_p.S738F	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1142										ovary(4)	4						TTCGTCTCTGGAATGAGCCCC	0.478													11	26					0	0	0	0	A	79947378	A	A	79947378	3	1	78	1	0	0	0	0	1	0	0	0	1531	1174	41	2	2031	2	BRWD3	23	79947378	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	248909	79947378	75323182	296	15823											
SH3BGRL	6451	broad.mit.edu	37	chrX	80532534	80532534	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctagaagccaacaaaataGgatttgaagaaaaagatatt	20	9	7	5	0	0	4	0	1	0	3	1	5	1	5	2	1	2	0	2	1	10	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:80532534G>T	uc004eef.2	+	2	494	c.97G>T	c.(97-99)GGA>TGA	p.G33*	SH3BGRL_uc011mqs.1_RNA|SH3BGRL_uc010nml.2_RNA|SH3BGRL_uc010nmm.2_Nonsense_Mutation_p.G70*|SH3BGRL_uc010nmn.2_Nonsense_Mutation_p.G70*	NM_003022	NP_003013	O75368	SH3L1_HUMAN	SH3 domain binding glutamic acid-rich protein	33						cytoplasm|nucleus	SH3 domain binding|SH3/SH2 adaptor activity	p.G33G(1)		ovary(1)	1		all_lung(315;5.94e-05)				CAACAAAATAGGATTTGAAGA	0.398													11	40					6.81908e-15	8.86941e-15	1	0	T	80532534	T	T	80532534	4	4	78	1	0	0	0	0	0	1	0	0	14306	1001	35	4	103	4	SH3BGRL	23	80532534	Nonsense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	585156	80532534	74738026	297	15824											
DACH2	117154	broad.mit.edu	37	chrX	85404039	85404039	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcgggctgggggccatccagCccggggtaaaccgctgcaaa	8	4	16	13	3	0	0	0	0	0	0	1	0	1	0	4	5	3	4	4	5	3	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:85404039C>G	uc004eew.2	+	1	585	c.415C>G	c.(415-417)CCC>GCC	p.P139A	DACH2_uc004eex.2_Missense_Mutation_p.P139A|DACH2_uc010nmq.2_5'UTR	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	139	DACHbox-N.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						GGCCATCCAGCCCGGGGTAAA	0.557													13	47					0	0	0	0	G	85404039	G	G	85404039	3	3	78	1	0	0	0	0	1	0	0	0	4238	739	26	4	417	4	DACH2	23	85404039	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	4871505	85404039	69866521	298	15825											
DACH2	117154	broad.mit.edu	37	chrX	85994870	85994870	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccctctcagatggatcatCatttggaaagaatgggtgag	11	11	11	8	0	3	3	3	1	1	2	5	5	4	5	1	3	0	0	1	3	2	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:85994870C>A	uc004eew.2	+	7	1395	c.1225C>A	c.(1225-1227)CAT>AAT	p.H409N	DACH2_uc004eex.2_Missense_Mutation_p.H396N|DACH2_uc010nmq.2_Missense_Mutation_p.H275N|DACH2_uc011mra.1_Missense_Mutation_p.H242N|DACH2_uc010nmr.2_Missense_Mutation_p.H190N|DACH2_uc004eey.2_Missense_Mutation_p.H92N|DACH2_uc004eez.2_Missense_Mutation_p.H92N	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						GATGGATCATCATTTGGAAAG	0.443													5	12					3.59834e-05	3.84822e-05	1	0	A	85994870	A	A	85994870	3	1	78	1	0	0	0	0	1	0	0	0	4238	826	29	2	1251	2	DACH2	23	85994870	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	590831	85994870	69275690	299	15826											
DACH2	117154	broad.mit.edu	37	chrX	86067962	86067962	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccctggaccattcattttTgctgatagtctgtcctccgt	5	17	7	12	1	2	1	1	1	1	0	5	2	5	2	4	1	1	1	4	1	1	5			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:86067962T>G	uc004eew.2	+	8	1514	c.1344T>G	c.(1342-1344)TTT>TTG	p.F448L	DACH2_uc004eex.2_Missense_Mutation_p.F435L|DACH2_uc010nmq.2_Missense_Mutation_p.F314L|DACH2_uc011mra.1_Missense_Mutation_p.F281L|DACH2_uc010nmr.2_Missense_Mutation_p.F229L|DACH2_uc004eey.2_Missense_Mutation_p.F131L|DACH2_uc004eez.2_Missense_Mutation_p.F131L	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						CATTCATTTTTGCTGATAGTC	0.423													8	15					0	0	0	0	G	86067962	G	G	86067962	3	3	78	1	0	0	0	0	1	0	0	0	4238	1809	63	5	1374	5	DACH2	23	86067962	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	73092	86067962	69202598	300	15827											
NAP1L3	4675	broad.mit.edu	37	chrX	92928013	92928013	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcctgaggcagcctatcCacgaaatttgttcccaacgg	10	9	9	13	2	0	1	0	1	0	0	2	2	2	1	4	2	3	2	4	2	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:92928013C>T	uc004efq.2	-	1	596	c.291G>A	c.(289-291)GTG>GTA	p.V97V	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	97					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						GCAGCCTATCCACGAAATTTG	0.423													13	26					0	0	0	0	T	92928013	T	T	92928013	2	4	78	1	0	0	0	0	0	0	0	1	10211	581	21	4		4	NAP1L3	23	92928013	Silent	SNP	C	TCGA-CN-6021-01A-11D-1683-08	6860051	92928013	62342547	301	15828											
DIAPH2	1730	broad.mit.edu	37	chrX	96220178	96220178	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagatctctttgccaaattGgcattgaattttgctactca	10	15	6	10	0	2	2	1	1	1	1	3	2	2	2	2	1	3	2	2	1	3	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:96220178G>T	uc004efu.3	+	17	2418	c.2022G>T	c.(2020-2022)TTG>TTT	p.L674F	DIAPH2_uc004eft.3_Missense_Mutation_p.L674F	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	674	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						TTGCCAAATTGGCATTGAATT	0.303													9	26					0.000274275	0.000286168	1	0	T	96220178	T	T	96220178	3	4	78	1	0	0	0	0	1	0	0	0	4541	1339	47	4	2088	4	DIAPH2	23	96220178	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	3292165	96220178	59050382	302	15829											
DRP2	1821	broad.mit.edu	37	chrX	100486665	100486665	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatggtcatgcagggatgccCttacaccctcccacgatgtc	8	10	9	14	1	1	0	1	0	0	0	3	2	2	1	3	2	3	1	3	2	2	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:100486665C>T	uc004egz.2	+	3	398	c.29C>T	c.(28-30)CCT>CTT	p.P10L	DRP2_uc011mrh.1_Intron	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	10					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						CAGGGATGCCCTTACACCCTC	0.537													50	125					0	0	0	0	T	100486665	T	T	100486665	3	4	78	1	0	0	0	0	1	0	0	0	4786	681	24	4	31	4	DRP2	23	100486665	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	4266487	100486665	54783895	303	15830											
ARMCX2	9823	broad.mit.edu	37	chrX	100911056	100911056	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtttgcaatggaattgaCaagcaggtgctggtagtcat	13	11	12	5	0	1	1	1	1	0	0	1	2	1	2	0	3	3	5	0	3	5	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:100911056C>G	uc004eid.2	-	3	1874	c.1519G>C	c.(1519-1521)GTC>CTC	p.V507L	ARMCX2_uc004eie.3_Missense_Mutation_p.V507L|ARMCX2_uc004eif.3_Missense_Mutation_p.V507L|ARMCX2_uc004eig.3_Missense_Mutation_p.V507L|ARMCX2_uc010nnt.2_Missense_Mutation_p.V507L	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	507	ARM 3.					integral to membrane	binding			ovary(6)	6						ATGGAATTGACAAGCAGGTGC	0.378													13	186					0	0	0	0	G	100911056	G	G	100911056	3	3	78	1	0	0	0	0	1	0	0	0	962	478	17	4	383	4	ARMCX2	23	100911056	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	424391	100911056	54359504	304	15831											
MID2	11043	broad.mit.edu	37	chrX	107169922	107169922	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatgcaattggcattgcctaCaaatcagctccaaagaatga	15	10	7	9	0	1	2	1	1	0	1	2	2	2	2	2	1	4	3	2	1	6	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:107169922C>A	uc004enl.2	+	10	2400	c.1827C>A	c.(1825-1827)TAC>TAA	p.Y609*	MID2_uc004enk.2_Nonsense_Mutation_p.Y579*	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	609	B30.2/SPRY.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						GCATTGCCTACAAATCAGCTC	0.393													21	72					6.21321e-17	8.27712e-17	1	0	A	107169922	A	A	107169922	4	1	78	1	0	0	0	0	0	1	0	0	9631	489	17	4	1865	4	MID2	23	107169922	Nonsense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	6258866	107169922	48100638	305	15832											
COL4A5	1287	broad.mit.edu	37	chrX	107802347	107802347	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggattgcctggatttccAggtccagaagggcctccggg	7	8	14	12	1	0	1	0	0	0	1	3	3	3	3	6	5	1	0	6	5	1	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:107802347A>C	uc004enz.1	+	3	397	c.195A>C	c.(193-195)CCA>CCC	p.P65P	COL4A5_uc011mso.1_Silent_p.P65P	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	65	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						CTGGATTTCCAGGTCCAGAAG	0.463									Alport_syndrome_with_Diffuse_Leiomyomatosis				21	89					0	0	0	0	C	107802347	C	C	107802347	2	2	78	1	0	0	0	0	0	0	0	1	3709	175	7	5		5	COL4A5	23	107802347	Silent	SNP	A	TCGA-CN-6021-01A-11D-1683-08	632425	107802347	47468213	306	15833											
KLHL13	90293	broad.mit.edu	37	chrX	117079426	117079426	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagaactgtgggtattgcTggtaaagatgcgtgtaggtc	10	11	14	6	1	0	2	0	0	0	2	1	2	0	2	0	3	3	4	0	3	5	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:117079426T>C	uc004eql.2	-	2	273	c.211A>G	c.(211-213)AGC>GGC	p.S71G	KLHL13_uc004eqk.2_Missense_Mutation_p.S20G|KLHL13_uc011mtn.1_5'UTR|KLHL13_uc011mto.1_Missense_Mutation_p.S65G|KLHL13_uc011mtp.1_Missense_Mutation_p.S73G|KLHL13_uc004eqm.2_Missense_Mutation_p.S20G|KLHL13_uc011mtq.1_Missense_Mutation_p.S55G	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	71					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						TGGGTATTGCTGGTAAAGATG	0.433													24	64					0	0	0	0	C	117079426	C	C	117079426	3	2	78	1	0	0	0	0	1	0	0	0	8408	1580	55	5	1780	5	KLHL13	23	117079426	Missense_Mutation	SNP	T	TCGA-CN-6021-01A-11D-1683-08	9277079	117079426	38191134	307	15834											
DOCK11	139818	broad.mit.edu	37	chrX	117788710	117788710	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agccaagtcctatgcaagcaCcccagagctcaggaaaacct	14	5	8	14	0	1	1	1	0	0	1	2	2	2	2	5	1	5	3	5	1	5	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:117788710C>G	uc004eqp.2	+	43	4904	c.4841C>G	c.(4840-4842)ACC>AGC	p.T1614S	DOCK11_uc004eqq.2_Missense_Mutation_p.T1393S	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1614	DHR-2.				blood coagulation	cytosol	GTP binding			ovary(3)	3						TATGCAAGCACCCCAGAGCTC	0.433													31	80					0	0	0	0	G	117788710	G	G	117788710	3	3	78	1	0	0	0	0	1	0	0	0	4708	507	18	4	5011	4	DOCK11	23	117788710	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	709284	117788710	37481850	308	15835											
KIAA1210	57481	broad.mit.edu	37	chrX	118221772	118221772	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtctgcctcaatagcagcccGctcgaaatttgaggacagtt	10	10	10	11	2	2	1	1	1	1	0	3	3	2	2	2	1	3	3	2	1	3	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:118221772G>T	uc004era.3	-	11	3421	c.3421C>A	c.(3421-3423)CGG>AGG	p.R1141R		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1141										ovary(4)|skin(1)	5						ATAGCAGCCCGCTCGAAATTT	0.468													19	78					2.37509e-13	3.05823e-13	1	0	T	118221772	T	T	118221772	2	4	78	1	0	0	0	0	0	0	0	1	8253	1086	38	3		3	KIAA1210	23	118221772	Silent	SNP	G	TCGA-CN-6021-01A-11D-1683-08	433062	118221772	37048788	309	15836											
NKAP	79576	broad.mit.edu	37	chrX	119077487	119077487	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcagatttgctgggcttcgGactcttcgacgaactgcgac	7	10	13	11	4	1	1	0	0	1	1	3	5	1	2	0	3	3	3	0	3	1	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:119077487G>T	uc004esh.2	-	1	249	c.82C>A	c.(82-84)CCG>ACG	p.P28T		NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	28	Ser-rich.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						CTGGGCTTCGGACTCTTCGAC	0.701													19	39					6.44725e-10	7.83026e-10	1	0	T	119077487	T	T	119077487	3	4	78	1	0	0	0	0	1	0	0	0	10493	1174	41	2	1201	2	NKAP	23	119077487	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	855715	119077487	36193073	310	15837											
THOC2	57187	broad.mit.edu	37	chrX	122866840	122866840	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcccagttctttatccaCtctgcgggaaccaccacagc	8	11	6	16	1	3	0	0	0	3	0	5	1	4	1	4	1	3	1	4	1	2	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:122866840C>A	uc004etu.2	-	1	65	c.33G>T	c.(31-33)GAG>GAT	p.E11D	THOC2_uc011mui.1_5'UTR	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	11					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TCTTTATCCACTCTGCGGGAA	0.637											OREG0003979|OREG0003978	type=REGULATORY REGION|Gene=THOC2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|Gene=BC041435|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	18	54					5.03518e-11	6.25337e-11	1	0	A	122866840	A	A	122866840	3	1	78	1	0	0	0	0	1	0	0	0	15931	564	20	4	4900	4	THOC2	23	122866840	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	3789353	122866840	32403720	311	15838											
XPNPEP2	7512	broad.mit.edu	37	chrX	128896688	128896688	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacctggttactataaggAtggagaatttgggatccgtc	12	11	12	6	1	0	2	0	0	0	2	2	5	1	4	2	4	2	1	2	4	5	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:128896688A>T	uc004eut.1	+	19	1926	c.1682A>T	c.(1681-1683)GAT>GTT	p.D561V		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	561					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						TACTATAAGGATGGAGAATTT	0.542													19	44					0	0	0	0	T	128896688	T	T	128896688	3	4	78	1	0	0	0	0	1	0	0	0	17511	333	12	5	1756	5	XPNPEP2	23	128896688	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	6029848	128896688	26373872	312	15839											
UTP14A	10813	broad.mit.edu	37	chrX	129053151	129053151	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgttttgttgcttctttaagGcaagaactcccctggagcag	8	14	10	9	0	1	1	0	0	1	1	2	2	2	2	2	2	3	5	2	2	3	6			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:129053151G>T	uc004euz.2	+	7	566	c.538G>T	c.(538-540)GCA>TCA	p.A180S	UTP14A_uc011mup.1_Missense_Mutation_p.A128S|UTP14A_uc011muq.1_Missense_Mutation_p.A126S|UTP14A_uc004eva.1_5'Flank	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	180					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						CTTCTTTAAGGCAAGAACTCC	0.433													29	79					3.69857e-22	5.17799e-22	1	0	T	129053151	T	T	129053151	3	4	78	1	0	0	0	0	1	0	0	0	17163	1217	42	4	564	4	UTP14A	23	129053151	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	156463	129053151	26217409	313	15840											
GPR119	139760	broad.mit.edu	37	chrX	129518602	129518602	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcatagatgagtgggttgaGcagggagttgcccacgccga	9	7	17	8	2	0	3	0	2	0	1	0	5	0	4	2	3	2	4	2	3	1	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:129518602G>C	uc011muv.1	-	1	820	c.820C>G	c.(820-822)CTC>GTC	p.L274V		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	274	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						AGTGGGTTGAGCAGGGAGTTG	0.567													31	64					0	0	0	0	C	129518602	C	C	129518602	3	2	78	1	0	0	0	0	1	0	0	0	6672	971	34	4	191	4	GPR119	23	129518602	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	465451	129518602	25751958	314	15841											
MST4	51765	broad.mit.edu	37	chrX	131207017	131207017	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gacgagaataacgctagcagGaatcaggcgattgaagaact	16	6	12	7	3	1	3	1	1	0	2	1	7	1	4	0	2	3	2	0	2	6	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:131207017G>C	uc004ewk.1	+	11	1423	c.1122G>C	c.(1120-1122)AGG>AGC	p.R374S	MST4_uc004ewl.1_Missense_Mutation_p.R297S|MST4_uc011mux.1_Missense_Mutation_p.R396S|MST4_uc010nrj.1_Missense_Mutation_p.R350S|MST4_uc004ewm.1_Missense_Mutation_p.R312S	NM_016542	NP_057626	Q9P289	MST4_HUMAN	serine/threonine protein kinase MST4 isoform 1	374					cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(3)|stomach(2)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(192;0.000127)					ACGCTAGCAGGAATCAGGCGA	0.368													44	68					0	0	0	0	C	131207017	C	C	131207017	3	2	78	1	0	0	0	0	1	0	0	0	9945	1165	41	2	1160	2	MST4	23	131207017	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1688415	131207017	24063543	315	15842											
TFDP3	51270	broad.mit.edu	37	chrX	132351548	132351548	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggatgactgagttgggcAgcggccgctggctgacctgc	5	8	17	11	3	0	3	0	3	0	0	0	4	0	4	2	4	2	4	2	4	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:132351548A>T	uc004exb.1	-	1	829	c.740T>A	c.(739-741)CTG>CAG	p.L247Q		NM_016521	NP_057605	Q5H9I0	TFDP3_HUMAN	transcription factor Dp family, member 3	247	Involved in negatively regulating E2F activity.					transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TGAGTTGGGCAGCGGCCGCTG	0.478													41	135					0	0	0	0	T	132351548	T	T	132351548	3	4	78	1	0	0	0	0	1	0	0	0	15865	188	7	5	481	5	TFDP3	23	132351548	Missense_Mutation	SNP	A	TCGA-CN-6021-01A-11D-1683-08	1144531	132351548	22919012	316	15843											
FHL1	2273	broad.mit.edu	37	chrX	135291444	135291444	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagccacccagtctctaaagCtaggaagcccccagtgtgcc	10	6	10	15	0	1	0	0	0	1	0	2	2	1	1	5	1	4	1	5	1	4	2			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:135291444C>A	uc004ezo.2	+	6	831	c.731C>A	c.(730-732)GCT>GAT	p.A244D	FHL1_uc010nrz.2_Intron|FHL1_uc004ezm.2_Intron|FHL1_uc004ezl.2_Intron|FHL1_uc004ezq.2_Intron|FHL1_uc011mvy.1_Intron|FHL1_uc011mvz.1_Intron|FHL1_uc004ezn.2_Intron|FHL1_uc011mwa.1_Intron|FHL1_uc011mwb.1_Intron|FHL1_uc004ezp.2_Intron|FHL1_uc004ezr.2_Intron	NM_001159702	NP_001153174	Q13642	FHL1_HUMAN	four and a half LIM domains 1 isoform 1	244					cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)					GTCTCTAAAGCTAGGAAGCCC	0.572											OREG0019943	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	41					0.000442599	0.000460543	1	0	A	135291444	A	A	135291444	3	1	78	1	0	0	0	0	1	0	0	0	5910	797	28	4	866	4	FHL1	23	135291444	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	2939896	135291444	19979116	317	15844											
GPR112	139378	broad.mit.edu	37	chrX	135453552	135453552	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatccccagccctgggtaaaGaagagacaaagattattgtt	15	9	9	8	0	0	3	0	0	0	3	1	4	1	3	3	1	1	2	3	1	6	4			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:135453552G>C	uc004ezu.1	+	14	7753	c.7462G>C	c.(7462-7464)GAA>CAA	p.E2488Q	GPR112_uc010nsb.1_Missense_Mutation_p.E2283Q	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2488	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CCTGGGTAAAGAAGAGACAAA	0.338													12	32					0	0	0	0	C	135453552	C	C	135453552	3	2	78	1	0	0	0	0	1	0	0	0	6667	943	33	2	7504	2	GPR112	23	135453552	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	162108	135453552	19817008	318	15845											
PASD1	139135	broad.mit.edu	37	chrX	150789407	150789407	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcctctcctgccaggctgaGattgtgggcaaaaaattatt	10	12	9	10	0	1	1	0	1	1	1	3	2	2	1	3	2	1	2	3	2	4	3			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:150789407G>C	uc004fev.3	+	5	545	c.213G>C	c.(211-213)GAG>GAC	p.E71D		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	71	PAS.					nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GCCAGGCTGAGATTGTGGGCA	0.234													27	84					0	0	0	0	C	150789407	C	C	150789407	3	2	78	1	0	0	0	0	1	0	0	0	11525	933	33	2	227	2	PASD1	23	150789407	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	15335855	150789407	4481153	319	15846											
ATP2B3	492	broad.mit.edu	37	chrX	152814263	152814263	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctggtcgtggctgtccCagagggcctgcctcttgctg	2	12	15	12	1	1	1	0	0	1	1	3	1	2	1	3	3	3	3	3	3	0	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:152814263C>A	uc004fht.1	+	8	1415	c.1289C>A	c.(1288-1290)CCA>CAA	p.P430Q	ATP2B3_uc004fhs.1_Missense_Mutation_p.P430Q	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	430	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGGCTGTCCCAGAGGGCCTG	0.502													11	50					6.40141e-05	6.80813e-05	1	0	A	152814263	A	A	152814263	3	1	78	1	0	0	0	0	1	0	0	0	1143	594	21	4	1319	4	ATP2B3	23	152814263	Missense_Mutation	SNP	C	TCGA-CN-6021-01A-11D-1683-08	2024856	152814263	2456297	320	15847											
DKC1	1736	broad.mit.edu	37	chrX	153994589	153994589	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggagaagacagggcacaGtggtacgctggatcccaagg	11	5	17	8	1	0	2	0	0	0	2	1	4	1	3	1	6	1	3	1	6	3	1			TCGA-CN-6021-01A-11D-1683-08	TCGA-CN-6021-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	e62a2c4d-18e3-4ec8-8d93-40e055e65be4	ed345984-cb10-45e5-8684-460ae7e7e84b	g.chrX:153994589G>T	uc004fmm.2	+	5	572	c.362G>T	c.(361-363)AGT>ATT	p.S121I	DKC1_uc010nvf.2_Missense_Mutation_p.S121I|SNORA36A_uc004fmn.2_5'Flank	NM_001363	NP_001354	O60832	DKC1_HUMAN	dyskerin isoform 1	121					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity				0	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACAGGGCACAGTGGTACGCTG	0.522									Congenital_Dyskeratosis				24	58					7.87624e-14	1.01757e-13	1	0	T	153994589	T	T	153994589	3	4	78	1	0	0	0	0	1	0	0	0	4564	1029	36	4	380	4	DKC1	23	153994589	Missense_Mutation	SNP	G	TCGA-CN-6021-01A-11D-1683-08	1180326	153994589	1275971	321	15848											
MRPS15	64960	broad.mit.edu	37	chr1	36926866	36926866	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttggcagaggctgctcaccTtgttggccatttccaaagac	8	11	10	12	0	1	2	1	0	0	2	2	2	2	2	3	3	1	4	3	3	1	4			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:36926866T>C	uc001cas.2	-	4	463	c.299A>G	c.(298-300)AAG>AGG	p.K100R		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	100					translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCTGCTCACCTTGTTGGCCAT	0.393													17	32					0	0	0	0	C	36926866	C	C	36926866	3	2	79	1	0	0	0	0	1	0	0	0	9878	1623	56	5	494	5	MRPS15	1	36926866	Missense_Mutation	SNP	T	TCGA-CN-6022-01A-21D-1683-08		36926866	212323755	1	15849											
EPHA10	284656	broad.mit.edu	37	chr1	38187398	38187398	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggcccagcgtgagggcctCggccaggaagccgagcctct	6	5	15	15	3	1	1	0	1	1	0	2	3	1	2	5	4	3	0	5	4	1	0			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:38187398C>T	uc009vvi.2	-	11	2166	c.2080G>A	c.(2080-2082)GAG>AAG	p.E694K	EPHA10_uc001cbt.2_5'Flank|EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	694	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GTGAGGGCCTCGGCCAGGAAG	0.672													5	24					0	0	0	0	T	38187398	T	T	38187398	3	4	79	1	0	0	0	0	1	0	0	0	5190	893	31	1	974	1	EPHA10	1	38187398	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	1260532	38187398	211063223	2	15850											
RRAGC	64121	broad.mit.edu	37	chr1	39317431	39317431	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttttcaatacctgaattcTtggaaaaacaaatgggaaac	16	12	6	7	0	2	1	1	1	1	0	2	3	2	3	1	2	3	0	1	2	7	5			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:39317431T>C	uc001ccq.2	-	5	779	c.757_splice	c.e5-1	p.N253_splice	RRAGC_uc010oim.1_Splice_Site_p.N219_splice|RRAGC_uc001ccr.2_Splice_Site_p.N175_splice	NM_022157	NP_071440	Q9HB90	RRAGC_HUMAN	Ras-related GTP binding C						apoptosis|cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|RNA splicing|small GTPase mediated signal transduction|transcription, DNA-dependent	lysosome|nucleus	GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein heterodimerization activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)				ACCTGAATTCTTGGAAAAACA	0.323													16	66					0	0	0	0	C	39317431	C	C	39317431	5	2	79	1	0	0	0	0	0	0	1	0	13739	1623	56	5	456	5	RRAGC	1	39317431	Splice_Site	SNP	T	TCGA-CN-6022-01A-21D-1683-08	1130033	39317431	209933190	3	15851											
TMEM48	55706	broad.mit.edu	37	chr1	54269617	54269617	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacctggttggctgaggctGaaaacttcttgtcttcgtga	8	14	11	8	1	2	3	0	3	2	0	3	3	2	3	1	3	2	3	1	3	3	5			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:54269617G>C	uc001cvs.2	-	10	1291	c.1050C>G	c.(1048-1050)TTC>TTG	p.F350L	TMEM48_uc010onu.1_Missense_Mutation_p.F310L|TMEM48_uc001cvt.2_Missense_Mutation_p.F227L|TMEM48_uc009vzk.2_RNA|TMEM48_uc010onv.1_Missense_Mutation_p.F15L	NM_018087	NP_060557	Q9BTX1	NDC1_HUMAN	transmembrane protein 48	350	Cytoplasmic (Potential).				mRNA transport|nuclear pore complex assembly|nuclear pore distribution|protein transport|transmembrane transport	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore			ovary(1)|pancreas(1)	2						GGCTGAGGCTGAAAACTTCTT	0.308													36	185					0	0	0	0	C	54269617	C	C	54269617	3	2	79	1	0	0	0	0	1	0	0	0	16238	1281	45	2	1010	2	TMEM48	1	54269617	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	14952186	54269617	194981004	4	15852											
ST6GALNAC5	81849	broad.mit.edu	37	chr1	77510198	77510198	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtctacaacaacctgcatCtcctgagccaggtgctgccc	9	8	9	15	0	2	1	0	1	2	0	3	1	2	1	4	2	7	2	4	2	3	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:77510198C>T	uc001dhi.2	+	3	746	c.571C>T	c.(571-573)CTC>TTC	p.L191F	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	191	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						CAACCTGCATCTCCTGAGCCA	0.587													27	187					0	0	0	0	T	77510198	T	T	77510198	3	4	79	1	0	0	0	0	1	0	0	0	15293	913	32	2	581	2	ST6GALNAC5	1	77510198	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	23240581	77510198	171740423	5	15853											
CCDC18	343099	broad.mit.edu	37	chr1	93691976	93691976	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggaaataaggaaaagttTgaaaaacagttaaagaagaa	24	6	10	1	0	0	3	0	1	0	2	0	6	0	5	0	2	1	2	0	2	11	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:93691976T>G	uc001dpq.2	+	17	2784	c.2616T>G	c.(2614-2616)TTT>TTG	p.F872L	CCDC18_uc009wdl.1_Missense_Mutation_p.F389L	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	753	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AGGAAAAGTTTGAAAAACAGT	0.294													5	51					0	0	0	0	G	93691976	G	G	93691976	3	3	79	1	0	0	0	0	1	0	0	0	2807	1809	63	5	2682	5	CCDC18	1	93691976	Missense_Mutation	SNP	T	TCGA-CN-6022-01A-21D-1683-08	16181778	93691976	155558645	6	15854											
FCRLA	84824	broad.mit.edu	37	chr1	161681071	161681071	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gttctgcgctgccaggcctgGcaagactggccactgactca	7	8	12	14	1	2	2	1	1	1	1	2	2	2	2	3	3	2	3	3	3	1	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:161681071G>C	uc001gbe.2	+	4	617	c.375G>C	c.(373-375)TGG>TGC	p.W125C	FCRLA_uc001gbd.2_Missense_Mutation_p.W119C|FCRLA_uc001gbf.2_Intron|FCRLA_uc001gbg.2_Intron|FCRLA_uc009wuo.2_Intron|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	102	Ig-like C2-type 1.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			GCCAGGCCTGGCAAGACTGGC	0.577													6	49					0	0	0	0	C	161681071	C	C	161681071	3	2	79	1	0	0	0	0	1	0	0	0	5832	1212	42	4	389	4	FCRLA	1	161681071	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	67989095	161681071	87569550	7	15855											
PTPRC	5788	broad.mit.edu	37	chr1	198713307	198713307	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagggatccacccagtgagcCgtctccactagaggctgaat	11	7	11	12	1	1	3	0	2	1	1	3	4	2	4	4	2	1	1	4	2	3	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:198713307C>T	uc001gur.1	+	26	2996	c.2816C>T	c.(2815-2817)CCG>CTG	p.P939L	PTPRC_uc001gus.1_Missense_Mutation_p.P891L|PTPRC_uc001gut.1_Missense_Mutation_p.P778L	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	939	Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CCCAGTGAGCCGTCTCCACTA	0.294													5	31					0	0	0	0	T	198713307	T	T	198713307	3	4	79	1	0	0	0	0	1	0	0	0	12862	652	23	1	2925	1	PTPRC	1	198713307	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	37032236	198713307	50537314	8	15856											
FMN2	56776	broad.mit.edu	37	chr1	240601464	240601464	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcatgaattcagctctgacTttaaagacttctggaagaaa	14	11	9	7	0	3	4	1	2	2	2	3	5	3	5	0	2	1	2	0	2	5	4			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:240601464T>A	uc010pyd.1	+	16	5239	c.5014T>A	c.(5014-5016)TTT>ATT	p.F1672I	FMN2_uc010pye.1_Missense_Mutation_p.F1676I|FMN2_uc010pyg.1_Missense_Mutation_p.F268I	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1672	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGCTCTGACTTTAAAGACTT	0.383													15	117					0	0	0	0	A	240601464	A	A	240601464	3	1	79	1	0	0	0	0	1	0	0	0	5982	1609	56	5	5076	5	FMN2	1	240601464	Missense_Mutation	SNP	T	TCGA-CN-6022-01A-21D-1683-08	41888157	240601464	8649157	9	15857											
OR2AK2	391191	broad.mit.edu	37	chr1	248129300	248129300	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgagtggacttattatcttgCtactaccattcctagccatt	9	16	6	10	0	1	1	0	1	1	0	2	2	2	2	3	1	4	1	3	1	5	8			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr1:248129300C>G	uc010pzd.1	+	1	667	c.667C>G	c.(667-669)CTA>GTA	p.L223V	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	223	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TATTATCTTGCTACTACCATT	0.448													9	18					0	0	0	0	G	248129300	G	G	248129300	3	3	79	1	0	0	0	0	1	0	0	0	11040	796	28	4	669	4	OR2AK2	1	248129300	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	7527836	248129300	1121321	10	15858											
NCOA1	8648	broad.mit.edu	37	chr2	24929930	24929930	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcctgtaataataataacCgatcttattcaaacatccca	15	12	4	10	1	2	0	1	0	1	0	3	1	3	0	3	0	3	1	3	0	6	6			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr2:24929930C>A	uc002rfk.2	+	11	1849	c.1591C>A	c.(1591-1593)CGA>AGA	p.R531R	NCOA1_uc010eye.2_Silent_p.R531R|NCOA1_uc002rfi.2_Silent_p.R380R|NCOA1_uc002rfj.2_Silent_p.R531R|NCOA1_uc002rfl.2_Silent_p.R531R	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	531	Interaction with STAT3.|Ser-rich.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TAATAATAACCGATCTTATTC	0.443			T	PAX3	alveolar rhadomyosarcoma								16	83					2.23348e-06	2.51267e-06	1	0	A	24929930	A	A	24929930	2	1	79	1	0	0	0	0	0	0	0	1	10282	644	23	3		3	NCOA1	2	24929930	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08		24929930	218269443	11	15859											
SPTBN1	6711	broad.mit.edu	37	chr2	54849492	54849492	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgaaaagtatgaatcacttgCctctgaccttctggaatgga	12	12	9	8	0	3	3	1	3	2	0	3	5	3	5	2	2	1	1	2	2	5	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr2:54849492C>T	uc002rxu.2	+	9	1181	c.932C>T	c.(931-933)GCC>GTC	p.A311V	SPTBN1_uc002rxv.1_Missense_Mutation_p.A311V|SPTBN1_uc002rxx.2_Missense_Mutation_p.A298V	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	311	Spectrin 1.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GAATCACTTGCCTCTGACCTT	0.398													10	91					0	0	0	0	T	54849492	T	T	54849492	3	4	79	1	0	0	0	0	1	0	0	0	15185	739	26	4	1075	4	SPTBN1	2	54849492	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	29919562	54849492	188349881	12	15860											
RANBP2	5903	broad.mit.edu	37	chr2	109383270	109383270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taatcattggataacgactaCgatgaacctgaagcctctct	13	11	7	10	2	2	2	1	2	1	0	3	5	2	3	2	1	4	0	2	1	5	4			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr2:109383270C>T	uc002tem.3	+	20	6401	c.6275C>T	c.(6274-6276)ACG>ATG	p.T2092M		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2092	RanBD1 2.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						ATAACGACTACGATGAACCTG	0.413													62	360					0	0	0	0	T	109383270	T	T	109383270	3	4	79	1	0	0	0	0	1	0	0	0	13093	536	19	1	6353	1	RANBP2	2	109383270	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	54533778	109383270	133816103	13	15861											
ZNF80	7634	broad.mit.edu	37	chr3	113955725	113955725	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtgtgaatctgctgatgtCgaacaaggaggctgtttttg	9	13	13	6	1	1	2	0	2	1	0	2	4	1	3	0	2	2	3	0	2	3	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr3:113955725C>T	uc010hqo.2	-	1	701	c.197G>A	c.(196-198)CGA>CAA	p.R66Q	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	66	C2H2-type 1.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				CTGCTGATGTCGAACAAGGAG	0.488													4	30					0	0	0	0	T	113955725	T	T	113955725	3	4	79	1	0	0	0	0	1	0	0	0	18235	884	31	1	628	1	ZNF80	3	113955725	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08		113955725	84066705	14	15862											
PLXND1	23129	broad.mit.edu	37	chr3	129278515	129278515	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcggagattcccctcttctCagcctgctcctccaggaagt	6	11	9	15	1	2	1	1	0	2	1	7	3	5	2	5	2	2	1	5	2	1	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr3:129278515C>T	uc003emx.2	-	32	5345	c.5245G>A	c.(5245-5247)GAG>AAG	p.E1749K	PLXND1_uc003emw.2_5'Flank|PLXND1_uc011blb.1_Missense_Mutation_p.E417K	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1749	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CCCCTCTTCTCAGCCTGCTCC	0.582													41	133					0	0	0	0	T	129278515	T	T	129278515	3	4	79	1	0	0	0	0	1	0	0	0	12182	835	29	2	552	2	PLXND1	3	129278515	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	15322790	129278515	68743915	15	15863											
LAMP3	27074	broad.mit.edu	37	chr3	182841888	182841888	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attagattctctggtatccaGatgattgacaccttaggcgg	10	13	10	8	1	1	4	0	2	1	2	3	4	2	4	2	3	0	1	2	3	3	5			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr3:182841888G>C	uc003flh.3	-	6	1456	c.1232C>G	c.(1231-1233)TCT>TGT	p.S411C		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	411	Cytoplasmic (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			CTGGTATCCAGATGATTGACA	0.453													34	62					0	0	0	0	C	182841888	C	C	182841888	3	2	79	1	0	0	0	0	1	0	0	0	8659	942	33	2	22	2	LAMP3	3	182841888	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	53563373	182841888	15180542	16	15864											
CPN2	1370	broad.mit.edu	37	chr3	194063384	194063384	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggacagggctgggcaggcctGgccaggagcaggagggaggt	8	3	22	8	0	0	0	0	0	0	0	0	4	0	4	2	9	1	3	2	9	0	0			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr3:194063384G>A	uc003fts.2	-	2	138	c.48C>T	c.(46-48)GCC>GCT	p.A16A		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	16					protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GGGCAGGCCTGGCCAGGAGCA	0.592													6	68					0	0	0	0	A	194063384	A	A	194063384	2	1	79	1	0	0	0	0	0	0	0	1	3825	1335	47	4		4	CPN2	3	194063384	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	11221496	194063384	3959046	17	15865											
SLC26A1	10861	broad.mit.edu	37	chr4	982693	982693	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcacggcatcgtgcacactGaggaacagctgctcctcctc	8	8	10	15	2	0	1	0	1	0	0	4	2	2	2	2	2	5	5	2	2	1	0			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr4:982693G>A	uc003gcb.2	-	4	2412	c.2034C>T	c.(2032-2034)CTC>CTT	p.L678L	SLC26A1_uc003gbx.2_Intron|IDUA_uc003gby.2_Intron|IDUA_uc003gbz.2_Intron|IDUA_uc003gca.2_Intron|SLC26A1_uc003gcc.2_Silent_p.L678L	NM_213613	NP_998778	Q9H2B4	S26A1_HUMAN	solute carrier family 26, member 1 isoform a	678	STAS.					integral to membrane|plasma membrane	secondary active sulfate transmembrane transporter activity			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CGTGCACACTGAGGAACAGCT	0.672													4	15					0	0	0	0	A	982693	A	A	982693	2	1	79	1	0	0	0	0	0	0	0	1	14578	1277	45	2		2	SLC26A1	4	982693	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08		982693	190171583	18	15866											
RGS12	6002	broad.mit.edu	37	chr4	3432594	3432594	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacgtggccgagctgaccctGatgggggagggggacatcag	8	5	18	10	2	1	2	1	2	0	0	1	5	1	4	2	5	1	1	2	5	0	0			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr4:3432594G>A	uc003ggw.2	+	17	4930	c.4026G>A	c.(4024-4026)CTG>CTA	p.L1342L	RGS12_uc003ggv.2_Silent_p.L1342L|RGS12_uc003ggy.1_3'UTR|RGS12_uc003ggz.2_Silent_p.L694L|RGS12_uc011bvs.1_3'UTR|RGS12_uc003gha.2_Silent_p.L684L|RGS12_uc010icv.2_Silent_p.L541L	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1342						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AGCTGACCCTGATGGGGGAGG	0.672													7	56					0	0	0	0	A	3432594	A	A	3432594	2	1	79	1	0	0	0	0	0	0	0	1	13360	1277	45	2		2	RGS12	4	3432594	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	2449901	3432594	187721682	19	15867											
LIN54	132660	broad.mit.edu	37	chr4	83891502	83891502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatttggcgatttcaaaggtGagatggctattttatttggt	9	18	11	3	1	1	1	1	1	0	1	1	3	1	1	0	4	0	1	0	4	4	7			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr4:83891502G>A	uc003hnx.3	-	4	1307	c.929C>T	c.(928-930)TCA>TTA	p.S310L	LIN54_uc003hnz.3_Missense_Mutation_p.S89L|LIN54_uc003hny.3_5'UTR|LIN54_uc010ijt.2_Intron|LIN54_uc010iju.2_5'UTR|LIN54_uc010ijv.2_Missense_Mutation_p.S89L	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	310					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				TTTCAAAGGTGAGATGGCTAT	0.333													16	97					0	0	0	0	A	83891502	A	A	83891502	3	1	79	1	0	0	0	0	1	0	0	0	8851	1294	45	2	1360	2	LIN54	4	83891502	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	80458908	83891502	107262774	20	15868											
NFKB1	4790	broad.mit.edu	37	chr4	103527776	103527776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttgcacctagctgccaaaGaaggacatgataaagttctc	13	11	8	9	0	1	2	0	1	1	1	2	3	1	3	2	1	3	3	2	1	5	5			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr4:103527776G>A	uc011ceq.1	+	17	2340	c.1873G>A	c.(1873-1875)GAA>AAA	p.E625K	NFKB1_uc011cep.1_Missense_Mutation_p.E626K|NFKB1_uc011cer.1_Missense_Mutation_p.E445K	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	625	Interaction with CFLAR.|ANK 3.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	AGCTGCCAAAGAAGGACATGA	0.502													11	72					0	0	0	0	A	103527776	A	A	103527776	3	1	79	1	0	0	0	0	1	0	0	0	10429	943	33	2	1938	2	NFKB1	4	103527776	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	19636274	103527776	87626500	21	15869											
FAM149A	25854	broad.mit.edu	37	chr4	187088346	187088346	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttccagcagtcggatacGcctcgaaaaagttcattgac	11	11	8	11	3	2	1	1	1	1	0	5	3	3	2	2	1	2	2	2	1	3	5	rs150961217		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr4:187088346G>T	uc003iyt.3	+	13	1884	c.1305G>T	c.(1303-1305)ACG>ACT	p.T435T	FAM149A_uc011cla.1_Silent_p.T435T|FAM149A_uc003iyu.3_Silent_p.T435T|FAM149A_uc010isl.2_Silent_p.T435T|FAM149A_uc011clb.1_Silent_p.T434T	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	726										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		AGTCGGATACGCCTCGAAAAA	0.368													21	110					7.41877e-09	8.70899e-09	1	0	T	187088346	T	T	187088346	2	4	79	1	0	0	0	0	0	0	0	1	5483	1074	38	3		3	FAM149A	4	187088346	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	83560570	187088346	4065930	22	15870											
C5orf35	133383	broad.mit.edu	37	chr5	56212663	56212663	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacttcgatgtgttgttctTgtcgcacttagggacatcaa	8	14	9	10	2	2	0	1	0	1	0	4	2	2	1	1	1	0	3	1	1	2	5			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr5:56212663T>G	uc003jqx.2	+	6	1207	c.834T>G	c.(832-834)CTT>CTG	p.L278L	C5orf35_uc003jqy.2_RNA	NM_153706	NP_714917	Q8NE22	CE035_HUMAN	hypothetical protein LOC133383	278										ovary(1)	1		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.173)		OV - Ovarian serous cystadenocarcinoma(10;2.58e-39)		GTGTTGTTCTTGTCGCACTTA	0.333													13	25					0	0	0	0	G	56212663	G	G	56212663	2	3	79	1	0	0	0	0	0	0	0	1	2304	1799	63	5		5	C5orf35	5	56212663	Silent	SNP	T	TCGA-CN-6022-01A-21D-1683-08		56212663	124702597	23	15871											
DEPDC1B	55789	broad.mit.edu	37	chr5	59982801	59982801	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccattacctgtataagtgaCgattgtcttcaaaatcttcc	11	14	6	10	1	3	1	1	1	2	0	4	2	4	1	3	0	1	1	3	0	5	6			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr5:59982801C>G	uc003jsh.2	-	2	375	c.302G>C	c.(301-303)CGT>CCT	p.R101P	DEPDC1B_uc011cqm.1_Missense_Mutation_p.R101P|DEPDC1B_uc011cqn.1_Missense_Mutation_p.R74P	NM_018369	NP_060839	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B isoform 1	101	DEP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)	1		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				GTATAAGTGACGATTGTCTTC	0.428													27	224					0	0	0	0	G	59982801	G	G	59982801	3	3	79	1	0	0	0	0	1	0	0	0	4462	536	19	3	1327	3	DEPDC1B	5	59982801	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	3770138	59982801	120932459	24	15872											
RAD17	5884	broad.mit.edu	37	chr5	68680680	68680680	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagcagttttcaaagagtttCtactaagagcgacaaagtat	15	12	8	6	1	2	2	1	0	1	2	2	3	2	2	0	0	3	4	0	0	6	7			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr5:68680680C>T	uc003jwo.2	+	5	660	c.598C>T	c.(598-600)CTA>TTA	p.L200L	RAD17_uc003jwg.2_Silent_p.L189L|RAD17_uc003jwh.2_Silent_p.L189L|RAD17_uc003jwi.2_Silent_p.L189L|RAD17_uc003jwj.2_Silent_p.L189L|RAD17_uc003jwk.2_Silent_p.L189L|RAD17_uc003jwl.2_Silent_p.L189L|RAD17_uc003jwm.2_Silent_p.L24L|RAD17_uc003jwn.2_Silent_p.L103L	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	200					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		CAAAGAGTTTCTACTAAGAGC	0.323								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					10	43					0	0	0	0	T	68680680	T	T	68680680	2	4	79	1	0	0	0	0	0	0	0	1	13044	912	32	2		2	RAD17	5	68680680	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08	8697879	68680680	112234580	25	15873											
CTNNA1	1495	broad.mit.edu	37	chr5	138145779	138145780	+	In_Frame_Ins	INS	-	GTG	GTG																															cagatgatccctgctcttctINSgtgaagcgaggcaacatggt																										TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr5:138145779_138145780insGTG	uc003ldh.2	+	4	449_450	c.354_355insGTG	c.(352-357)insGTG	p.119_120insV	CTNNA1_uc011cyx.1_In_Frame_Ins_p.16_17insV|CTNNA1_uc011cyy.1_Intron|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_In_Frame_Ins_p.119_120insV	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	119_120	Interaction with JUP and CTNNB1.|Involved in homodimerization.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCTGCTCTTCTGTGAAGCGAGG	0.455													---	---	---								GTG	138145780	GTG	GTG	138145779	7	5	79	1	0	1	1	0	0	0	0	0	4029	1567	55	0	364	0	CTNNA1	5	138145779	In_Frame_Ins	INS	-	TCGA-CN-6022-01A-21D-1683-08	69465099	138145779	42769481	26	15874											
PBX2	5089	broad.mit.edu	37	chr6	32154198	32154198	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacactccctggtccctcCgttggggatgtcactgaaga	8	10	11	12	1	1	3	1	2	0	1	4	4	4	4	3	3	1	1	3	3	2	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:32154198C>T	uc003oav.1	-	9	1525	c.1254G>A	c.(1252-1254)ACG>ACA	p.T418T	AGER_uc003oar.2_5'Flank|AGER_uc011dpm.1_5'Flank|AGER_uc011dpn.1_5'Flank|AGER_uc003oal.1_5'Flank|AGER_uc010jtv.1_5'Flank|AGER_uc011dpo.1_5'Flank|AGER_uc003oam.1_5'Flank|AGER_uc003oan.1_5'Flank|AGER_uc003oap.1_5'Flank|AGER_uc003oat.1_5'Flank|AGER_uc003oao.1_5'Flank|AGER_uc003oaq.1_5'Flank|AGER_uc010jtw.1_5'Flank|AGER_uc003oas.1_5'Flank|AGER_uc003oau.1_5'Flank|AGER_uc011dpp.1_5'Flank|AGER_uc011dpq.1_5'Flank|AGER_uc011dpr.1_5'Flank|AGER_uc011dps.1_5'Flank	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	418							transcription factor binding			ovary(1)	1						CTGGTCCCTCCGTTGGGGATG	0.572													3	32					0	0	0	0	T	32154198	T	T	32154198	2	4	79	1	0	0	0	0	0	0	0	1	11547	639	23	1		1	PBX2	6	32154198	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08		32154198	138960869	27	15875											
BTNL2	56244	broad.mit.edu	37	chr6	32363864	32363864	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtagacatcatctttttCaaaaaggcagcggtactgcc	11	11	9	10	1	3	1	2	0	1	1	3	1	3	1	1	3	3	3	1	3	4	4			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:32363864C>G	uc003obg.1	-	5	1030	c.1030G>C	c.(1030-1032)GAA>CAA	p.E344Q	BTNL2_uc010jty.1_Missense_Mutation_p.E67Q|BTNL2_uc010jtz.1_RNA|BTNL2_uc010jua.1_Missense_Mutation_p.E134Q	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	344	Extracellular (Potential).|Ig-like V-type 3.					integral to membrane				central_nervous_system(1)	1						TCATCTTTTTCAAAAAGGCAG	0.483													7	79					0	0	0	0	G	32363864	G	G	32363864	3	3	79	1	0	0	0	0	1	0	0	0	1570	835	29	2	345	2	BTNL2	6	32363864	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	209666	32363864	138751203	28	15876											
ZBTB22	9278	broad.mit.edu	37	chr6	33283477	33283477	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagggtgggagggggcatagGaagagggagttggcccccct	8	5	21	7	0	0	1	0	0	0	1	0	5	0	4	3	7	0	2	3	7	2	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:33283477G>A	uc003oeb.2	-	2	1369	c.1217C>T	c.(1216-1218)TCC>TTC	p.S406F	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.S406F	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	406					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGGGGCATAGGAAGAGGGAGT	0.592													33	212					0	0	0	0	A	33283477	A	A	33283477	3	1	79	1	0	0	0	0	1	0	0	0	17597	1174	41	2	691	2	ZBTB22	6	33283477	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	919613	33283477	137831590	29	15877											
SCUBE3	222663	broad.mit.edu	37	chr6	35213722	35213722	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgcttgccttcccagcAtccccatcctccattaccac	6	11	4	20	0	0	0	0	0	0	0	4	0	4	0	7	0	5	3	7	0	1	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:35213722A>G	uc003okf.1	+	20	2607	c.2601A>G	c.(2599-2601)TCA>TCG	p.S867S	SCUBE3_uc003okg.1_Silent_p.S866S|SCUBE3_uc003okh.1_Silent_p.S754S	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	867	CUB.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CCTTCCCAGCATCCCCATCCT	0.572													87	208					0	0	0	0	G	35213722	G	G	35213722	2	3	79	1	0	0	0	0	0	0	0	1	14011	231	8	5		5	SCUBE3	6	35213722	Silent	SNP	A	TCGA-CN-6022-01A-21D-1683-08	1930245	35213722	135901345	30	15878											
KIF6	221458	broad.mit.edu	37	chr6	39387750	39387750	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacttcttgcttcatttataCtttctcccagggccttggct	5	18	6	12	0	3	0	1	0	2	0	4	0	3	0	2	2	3	2	2	2	3	9			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:39387750C>G	uc003oot.2	-	15	1879	c.1784G>C	c.(1783-1785)AGT>ACT	p.S595T	KIF6_uc003oos.2_Missense_Mutation_p.S46T|KIF6_uc010jwz.1_5'UTR|KIF6_uc010jxa.1_Missense_Mutation_p.S386T|KIF6_uc011dua.1_Missense_Mutation_p.S595T|KIF6_uc010jxb.1_Missense_Mutation_p.S539T	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	595	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TTCATTTATACTTTCTCCCAG	0.358													11	89					0	0	0	0	G	39387750	G	G	39387750	3	3	79	1	0	0	0	0	1	0	0	0	8347	565	20	4	696	4	KIF6	6	39387750	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	4174028	39387750	131727317	31	15879											
EFHC1	114327	broad.mit.edu	37	chr6	52303383	52303383	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgttgactgtgaccaattCacacaggtatagcatatatt	12	14	8	7	0	1	2	1	2	0	0	1	2	1	2	1	1	1	4	1	1	5	8			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:52303383C>T	uc003pap.3	+	3	782	c.567C>T	c.(565-567)TTC>TTT	p.F189F	EFHC1_uc011dwv.1_Silent_p.F98F|EFHC1_uc011dww.1_Silent_p.F170F	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	189	DM10 1.					axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					GTGACCAATTCACACAGGTAT	0.383													8	86					0	0	0	0	T	52303383	T	T	52303383	2	4	79	1	0	0	0	0	0	0	0	1	4968	825	29	2		2	EFHC1	6	52303383	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08	12915633	52303383	118811684	32	15880											
ZNF292	23036	broad.mit.edu	37	chr6	87968682	87968682	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggtaaaaagtggatctcagGgtgctggtgaaacttcacaa	14	9	12	6	0	2	1	2	1	1	0	3	2	2	2	0	4	2	2	0	4	5	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:87968682G>T	uc003plm.3	+	8	5376	c.5335G>T	c.(5335-5337)GGT>TGT	p.G1779C		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TGGATCTCAGGGTGCTGGTGA	0.323													5	22					0.000602214	0.000656961	1	0	T	87968682	T	T	87968682	3	4	79	1	0	0	0	0	1	0	0	0	17893	1232	43	4	5365	4	ZNF292	6	87968682	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	35665299	87968682	83146385	33	15881											
LACE1	246269	broad.mit.edu	37	chr6	108843529	108843529	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggactctccatgtttacCggagaagaggaaatctttgc	12	10	11	8	1	2	2	0	0	2	2	3	6	2	4	2	3	2	1	2	3	4	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:108843529C>T	uc003psj.2	+	13	1533	c.1347C>T	c.(1345-1347)ACC>ACT	p.T449T		NM_145315	NP_660358	Q8WV93	LACE1_HUMAN	lactation elevated 1	449							ATP binding			central_nervous_system(1)	1		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		CCATGTTTACCGGAGAAGAGG	0.378													11	73					0	0	0	0	T	108843529	T	T	108843529	2	4	79	1	0	0	0	0	0	0	0	1	8635	639	23	1		1	LACE1	6	108843529	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08	20874847	108843529	62271538	34	15882											
CCDC28A	25901	broad.mit.edu	37	chr6	139101113	139101113	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttccactctggaaaacttCaagcatttggtaagcaatag	14	12	7	8	0	2	0	1	0	1	0	3	1	3	1	1	2	3	3	1	2	6	5			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:139101113C>A	uc003qie.2	+	3	738	c.583C>A	c.(583-585)CAA>AAA	p.Q195K		NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	195											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TGGAAAACTTCAAGCATTTGG	0.393													11	62					2.27111e-07	2.60936e-07	1	0	A	139101113	A	A	139101113	3	1	79	1	0	0	0	0	1	0	0	0	2815	827	29	2	593	2	CCDC28A	6	139101113	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	30257584	139101113	32013954	35	15883											
KATNA1	11104	broad.mit.edu	37	chr6	149919454	149919454	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatggagtctatctcatcAataaatatggtggctggaga	13	11	11	6	0	3	2	2	0	2	2	4	4	3	3	0	4	0	1	0	4	5	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:149919454A>C	uc003qmr.1	-	7	966	c.921T>G	c.(919-921)ATT>ATG	p.I307M	KATNA1_uc003qms.2_Missense_Mutation_p.I307M|KATNA1_uc003qmt.2_Missense_Mutation_p.I231M|KATNA1_uc011eed.1_Missense_Mutation_p.I231M	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1	307					cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		CTATCTCATCAATAAATATGG	0.393													20	59					0	0	0	0	C	149919454	C	C	149919454	3	2	79	1	0	0	0	0	1	0	0	0	8023	126	5	5	570	5	KATNA1	6	149919454	Missense_Mutation	SNP	A	TCGA-CN-6022-01A-21D-1683-08	10818341	149919454	21195613	36	15884											
SYNJ2	8871	broad.mit.edu	37	chr6	158483059	158483059	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgccacgcgggcgacacGcctatgatcaattttgactt	8	12	9	12	4	2	2	1	2	1	0	2	3	2	2	2	1	1	0	2	1	2	5			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:158483059G>A	uc003qqx.1	+	8	1065	c.990G>A	c.(988-990)ACG>ACA	p.T330T	SYNJ2_uc011efm.1_Intron|SYNJ2_uc003qqw.1_Silent_p.T330T|SYNJ2_uc003qqy.1_Silent_p.T43T|SYNJ2_uc011efn.1_Intron|SYNJ2_uc010kjo.1_Silent_p.T279T|SYNJ2_uc003qqz.1_5'UTR	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	330	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CGGGCGACACGCCTATGATCA	0.383													40	286					0	0	0	0	A	158483059	A	A	158483059	2	1	79	1	0	0	0	0	0	0	0	1	15519	1074	38	1		1	SYNJ2	6	158483059	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	8563605	158483059	12632008	37	15885											
PLG	5340	broad.mit.edu	37	chr6	161160163	161160163	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caagaagtgaatctcgaaccGcatgttcaggaaatagaagt	16	8	10	7	2	2	3	1	1	1	2	3	5	2	4	1	1	1	2	1	1	7	2	rs61731712		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr6:161160163G>A	uc003qtm.3	+	16	2004	c.1941G>A	c.(1939-1941)CCG>CCA	p.P647P		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	647	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATCTCGAACCGCATGTTCAGG	0.478													34	82					0	0	0	0	A	161160163	A	A	161160163	2	1	79	1	0	0	0	0	0	0	0	1	12141	1074	38	1		1	PLG	6	161160163	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	2677104	161160163	9954904	38	15886											
OCM	654231	broad.mit.edu	37	chr7	5920406	5920406	+	5'Flank	DEL	T	-	-																															tcttaatttaaaaaaaaaaaTaatctagacacacatacagt																								rs10235465		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr7:5920406delT	uc003spe.3	+							NM_001097622	NP_001091091	P0CE72	ONCO_HUMAN	oncomodulin								calcium ion binding				0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		aaaaaaaaaaTAATCTAGACA	0.229													---	---	---								-	5920406	-	-	5920406	6	5	79	0	1	1	0	1	0	0	0	0	10875	1421	49	0		0	OCM	7	5920406	5'Flank	DEL	T	TCGA-CN-6022-01A-21D-1683-08		5920406	153218257	39	15887											
ALKBH4	54784	broad.mit.edu	37	chr7	102098318	102098318	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acgggccggaagccctccagCcccgggtagaggcccatcct	7	4	13	17	3	0	1	0	0	0	1	2	2	2	2	7	4	2	1	7	4	2	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr7:102098318C>G	uc003uzl.2	-	3	437	c.432G>C	c.(430-432)GGG>GGC	p.G144G	ALKBH4_uc003uzm.2_Silent_p.G71G	NM_017621	NP_060091	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4	144						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AGCCCTCCAGCCCCGGGTAGA	0.667													9	50					0	0	0	0	G	102098318	G	G	102098318	2	3	79	1	0	0	0	0	0	0	0	1	529	726	26	4		4	ALKBH4	7	102098318	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08	96177912	102098318	57040345	40	15888											
ARHGEF5	7984	broad.mit.edu	37	chr7	144068318	144068318	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaaacatagctgtggatcAtttccaactttcaacttcac	12	14	4	11	0	4	0	3	0	1	0	5	1	5	1	1	1	4	1	1	1	5	5			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr7:144068318A>T	uc003wel.2	+	6	3714	c.3596A>T	c.(3595-3597)CAT>CTT	p.H1199L	ARHGEF5_uc003wek.2_Missense_Mutation_p.H1199L|ARHGEF5_uc003wem.2_Missense_Mutation_p.H54L	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1199	DH.				intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					GCTGTGGATCATTTCCAACTT	0.488													15	201					0	0	0	0	T	144068318	T	T	144068318	3	4	79	1	0	0	0	0	1	0	0	0	909	217	8	5	3614	5	ARHGEF5	7	144068318	Missense_Mutation	SNP	A	TCGA-CN-6022-01A-21D-1683-08	41970000	144068318	15070345	41	15889											
CUL1	8454	broad.mit.edu	37	chr7	148483659	148483659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcagttccaagaacccagagGaggcagaactagaagacaca	17	4	10	10	0	1	5	1	0	0	5	2	6	2	6	2	2	2	2	2	2	5	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr7:148483659G>A	uc010lpg.2	+	12	1841	c.1315G>A	c.(1315-1317)GAG>AAG	p.E439K	CUL1_uc003wey.2_Missense_Mutation_p.E439K|CUL1_uc003wez.2_Missense_Mutation_p.E329K|CUL1_uc003wfa.2_Missense_Mutation_p.E100K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	439					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GAACCCAGAGGAGGCAGAACT	0.378													17	36					0	0	0	0	A	148483659	A	A	148483659	3	1	79	1	0	0	0	0	1	0	0	0	4071	1175	41	2	1357	2	CUL1	7	148483659	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	4415341	148483659	10655004	42	15890											
ZFHX4	79776	broad.mit.edu	37	chr8	77616610	77616610	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagtttacagaaatacaTggaacaccactgccctaatg	14	9	6	12	0	0	1	0	0	0	1	1	2	1	2	3	1	4	1	3	1	5	4			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr8:77616610T>G	uc003yav.2	+	2	674	c.287T>G	c.(286-288)ATG>AGG	p.M96R	ZFHX4_uc003yat.1_Missense_Mutation_p.M96R|ZFHX4_uc003yau.1_Missense_Mutation_p.M96R|ZFHX4_uc003yaw.1_Missense_Mutation_p.M96R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	96						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGAAATACATGGAACACCAC	0.502										HNSCC(33;0.089)			66	125					0	0	0	0	G	77616610	G	G	77616610	3	3	79	1	0	0	0	0	1	0	0	0	17702	1464	51	5	289	5	ZFHX4	8	77616610	Missense_Mutation	SNP	T	TCGA-CN-6022-01A-21D-1683-08		77616610	68747412	43	15891											
PTP4A3	11156	broad.mit.edu	37	chr8	142441135	142441135	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgcacaagacccggtgctgCgttatgtagctcaggacctt	9	9	11	12	3	1	1	1	0	0	1	1	2	1	2	2	2	3	5	2	2	3	3	rs150126504	byFrequency	TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr8:142441135C>T	uc003ywg.1	+	5	847	c.513C>T	c.(511-513)TGC>TGT	p.C171C	PTP4A3_uc003ywh.1_Silent_p.C146C|PTP4A3_uc010met.1_Missense_Mutation_p.A85V	NM_032611	NP_116000	O75365	TP4A3_HUMAN	protein tyrosine phosphatase type IVA, member 3	171						early endosome|plasma membrane	identical protein binding|prenylated protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(97;2.55e-15)|all_epithelial(106;1.39e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0474)			CCCGGTGCTGCGTTATGTAGC	0.622													16	84					0	0	0	0	T	142441135	T	T	142441135	2	4	79	1	0	0	0	0	0	0	0	1	12835	776	27	1		1	PTP4A3	8	142441135	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08	64824525	142441135	3922887	44	15892											
DNAI1	27019	broad.mit.edu	37	chr9	34514718	34514718	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcttctactgtgttcgcagCagtcaccacagatgggaagg	9	10	11	11	1	3	1	1	0	2	1	4	2	3	2	1	2	2	3	1	2	2	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr9:34514718C>A	uc003zum.2	+	18	1992	c.1799C>A	c.(1798-1800)GCA>GAA	p.A600E		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	600	WD 4.				cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		GTGTTCGCAGCAGTCACCACA	0.567									Kartagener_syndrome				24	93					1.66031e-10	1.99237e-10	1	0	A	34514718	A	A	34514718	3	1	79	1	0	0	0	0	1	0	0	0	4631	710	25	4	1869	4	DNAI1	9	34514718	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08		34514718	106698713	45	15893											
SVEP1	79987	broad.mit.edu	37	chr9	113148250	113148250	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgccgtggccctgcagcaGaaaaccttccctacatttga	10	9	9	13	1	0	2	0	1	0	1	1	3	1	2	4	1	5	2	4	1	3	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr9:113148250G>A	uc010mtz.2	-	43	10502	c.10165C>T	c.(10165-10167)CTG>TTG	p.L3389L	SVEP1_uc010mty.2_Silent_p.L1315L	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3389	Sushi 33.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CCCTGCAGCAGAAAACCTTCC	0.493													4	50					0	0	0	0	A	113148250	A	A	113148250	2	1	79	1	0	0	0	0	0	0	0	1	15486	933	33	2		2	SVEP1	9	113148250	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	78633532	113148250	28065181	46	15894											
SPAG6	9576	broad.mit.edu	37	chr10	22690177	22690177	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgatgctcctcccaatattCtgaaacatgtggttggacag	11	12	9	9	0	1	2	0	2	1	0	3	3	3	3	2	2	2	2	2	2	3	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr10:22690177C>G	uc001iri.2	+	9	1427	c.1285C>G	c.(1285-1287)CTG>GTG	p.L429V	SPAG6_uc001irj.2_Missense_Mutation_p.L429V|SPAG6_uc010qct.1_Missense_Mutation_p.L399V|SPAG6_uc009xkh.2_Missense_Mutation_p.L407V	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	429					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						TCCCAATATTCTGAAACATGT	0.348													8	26					0	0	0	0	G	22690177	G	G	22690177	3	3	79	1	0	0	0	0	1	0	0	0	15048	912	32	2	1319	2	SPAG6	10	22690177	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08		22690177	112844570	47	15895											
OPN4	94233	broad.mit.edu	37	chr10	88425489	88425489	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccaaggggctgatccccaGccaggaccccaggatgtagg	10	4	14	13	0	0	1	0	1	0	0	1	4	1	3	6	5	1	2	6	5	2	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr10:88425489G>T	uc001kdq.2	+	10	1645	c.1418G>T	c.(1417-1419)AGC>ATC	p.S473I	LDB3_uc010qml.1_5'Flank|LDB3_uc010qmm.1_5'Flank|LDB3_uc001kdu.2_5'Flank|LDB3_uc001kdv.2_5'Flank|LDB3_uc009xsz.2_5'Flank|OPN4_uc001kdp.2_Missense_Mutation_p.S484I|OPN4_uc010qmk.1_Intron|LDB3_uc001kdr.2_5'Flank|LDB3_uc009xsy.2_5'Flank|LDB3_uc001kds.2_5'Flank|LDB3_uc001kdt.2_5'Flank	NM_033282	NP_150598	Q9UHM6	OPN4_HUMAN	opsin 4 isoform 1	473	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			ovary(1)	1						CTGATCCCCAGCCAGGACCCC	0.577													23	54					1.10923e-09	1.31645e-09	1	0	T	88425489	T	T	88425489	3	4	79	1	0	0	0	0	1	0	0	0	10936	971	34	4	1493	4	OPN4	10	88425489	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	65735312	88425489	47109258	48	15896											
COX15	1355	broad.mit.edu	37	chr10	101474430	101474430	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgactggtgagtggcggccaGaggagttgggacatacatca	10	8	16	7	1	1	3	1	2	0	1	1	5	1	5	1	5	1	1	1	5	1	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr10:101474430G>C	uc001kqb.3	-	9	1764	c.1147C>G	c.(1147-1149)CTG>GTG	p.L383V	COX15_uc001kqc.3_Intron|COX15_uc010qpj.1_Missense_Mutation_p.L204V	NM_078470	NP_510870	Q7KZN9	COX15_HUMAN	COX15 homolog isoform 1	383	Helical; (Potential).				heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		GTGGCGGCCAGAGGAGTTGGG	0.507													12	84					0	0	0	0	C	101474430	C	C	101474430	3	2	79	1	0	0	0	0	1	0	0	0	3779	933	33	2	159	2	COX15	10	101474430	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	13048941	101474430	34060317	49	15897											
SEC31B	25956	broad.mit.edu	37	chr10	102247522	102247522	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccacacatcgggcaacctCatggagcccagccacgacat	12	5	8	16	2	1	0	1	0	0	0	3	2	2	1	4	2	3	1	4	2	1	0			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr10:102247522C>T	uc001krc.1	-	26	3493	c.3391G>A	c.(3391-3393)GAG>AAG	p.E1131K	SEC31B_uc010qpo.1_Missense_Mutation_p.E1130K|SEC31B_uc001krd.1_Missense_Mutation_p.E668K|SEC31B_uc001krf.1_Missense_Mutation_p.E564K|SEC31B_uc001kre.1_Missense_Mutation_p.E562K	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	1131					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CGGGCAACCTCATGGAGCCCA	0.587													4	31					0	0	0	0	T	102247522	T	T	102247522	3	4	79	1	0	0	0	0	1	0	0	0	14064	835	29	2	152	2	SEC31B	10	102247522	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	773092	102247522	33287225	50	15898											
OR8H1	219469	broad.mit.edu	37	chr11	56057964	56057964	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtatcatgatttcaatgtcgTatgtgtccatgcaggacaga	11	13	10	7	1	2	2	2	1	0	1	4	3	3	3	1	1	1	3	1	1	3	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr11:56057964T>C	uc010rje.1	-	1	575	c.575A>G	c.(574-576)TAC>TGC	p.Y192C		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					TTCAATGTCGTATGTGTCCAT	0.443													14	71					0	0	0	0	C	56057964	C	C	56057964	3	2	79	1	0	0	0	0	1	0	0	0	11291	1638	57	5	362	5	OR8H1	11	56057964	Missense_Mutation	SNP	T	TCGA-CN-6022-01A-21D-1683-08		56057964	78948552	51	15899											
MLL2	8085	broad.mit.edu	37	chr12	49438545	49438545	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttcacccttgagcagctCatcggtgtccaggtccccat	7	10	8	16	1	2	1	2	1	0	0	5	1	4	1	5	2	2	2	5	2	0	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:49438545C>A	uc001rta.3	-	19	4945	c.4945G>T	c.(4945-4947)GAG>TAG	p.E1649*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1649					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTGAGCAGCTCATCGGTGTCC	0.607			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			17	50					9.7654e-05	0.000107619	1	0	A	49438545	A	A	49438545	4	1	79	1	0	0	0	0	0	1	0	0	9674	835	29	2	11812	2	MLL2	12	49438545	Nonsense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08		49438545	84413350	52	15900											
TRHDE	29953	broad.mit.edu	37	chr12	72666978	72666978	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagccgtggacgcagctgcgCctgtcgggccacctgaagcc	6	5	15	15	4	0	1	0	1	0	0	1	3	0	2	5	2	4	2	5	2	1	0			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:72666978C>T	uc001sxa.2	+	1	450	c.420C>T	c.(418-420)CGC>CGT	p.R140R	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	140	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CGCAGCTGCGCCTGTCGGGCC	0.697													5	25					0	0	0	0	T	72666978	T	T	72666978	2	4	79	1	0	0	0	0	0	0	0	1	16546	726	26	4		4	TRHDE	12	72666978	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08	23228433	72666978	61184917	53	15901											
CUX2	23316	broad.mit.edu	37	chr12	111758444	111758444	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacgtgccgcgcaccctgaaGcccaccgtgccgccgctgac	6	5	11	19	6	0	2	0	2	0	0	0	2	0	2	6	0	4	2	6	0	2	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:111758444G>A	uc001tsa.1	+	17	2784	c.2631G>A	c.(2629-2631)AAG>AAA	p.K877K		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	877						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCACCCTGAAGCCCACCGTGC	0.701													4	12					0	0	0	0	A	111758444	A	A	111758444	2	1	79	1	0	0	0	0	0	0	0	1	4082	962	34	4		4	CUX2	12	111758444	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	39091466	111758444	22093451	54	15902											
TRAFD1	10906	broad.mit.edu	37	chr12	112578685	112578685	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatttagaactttccattctCaaactgaaggaacatgaaga	16	11	7	7	0	1	4	1	2	1	2	3	6	2	5	1	1	3	0	1	1	6	4			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:112578685C>G	uc001ttp.2	+	5	386	c.300C>G	c.(298-300)CTC>CTG	p.L100L	TRAFD1_uc001tto.2_Silent_p.L100L|TRAFD1_uc009zwb.2_Silent_p.L100L|TRAFD1_uc010syj.1_RNA	NM_006700	NP_006691	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	100	TRAF-type.				negative regulation of innate immune response	intracellular	protein binding|zinc ion binding				0						TTTCCATTCTCAAACTGAAGG	0.463													22	73					0	0	0	0	G	112578685	G	G	112578685	2	3	79	1	0	0	0	0	0	0	0	1	16514	813	29	2		2	TRAFD1	12	112578685	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08	820241	112578685	21273210	55	15903											
P2RX7	5027	broad.mit.edu	37	chr12	121605311	121605311	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcggaataatgggcattgaGatctactgggactgcaacct	11	9	13	8	1	1	1	0	1	1	1	1	4	1	3	1	4	3	2	1	4	4	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:121605311G>A	uc001tzm.2	+	8	861	c.765G>A	c.(763-765)GAG>GAA	p.E255E	P2RX7_uc001tzn.2_Silent_p.E165E|P2RX7_uc001tzo.2_Intron|P2RX7_uc001tzp.2_Intron|P2RX7_uc001tzq.2_Silent_p.E85E	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	255						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGGGCATTGAGATCTACTGGG	0.537													16	80					0	0	0	0	A	121605311	A	A	121605311	2	1	79	1	0	0	0	0	0	0	0	1	11399	933	33	2		2	P2RX7	12	121605311	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	9026626	121605311	12246584	56	15904											
DNAH10	196385	broad.mit.edu	37	chr12	124268604	124268604	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaaagtcttggatgtgatCaaggaatccgactccatgct	13	10	10	8	1	2	2	1	1	1	1	4	5	4	4	2	2	1	1	2	2	4	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:124268604C>T	uc001uft.3	+	8	952	c.927C>T	c.(925-927)ATC>ATT	p.I309I		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	309	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGGATGTGATCAAGGAATCCG	0.463													28	41					0	0	0	0	T	124268604	T	T	124268604	2	4	79	1	0	0	0	0	0	0	0	1	4620	816	29	2		2	DNAH10	12	124268604	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08	2663293	124268604	9583291	57	15905											
DNAH10	196385	broad.mit.edu	37	chr12	124285882	124285882	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatcacatgctcataggaacGttaaacgatgcggagtctgt	12	11	10	8	3	3	0	2	0	1	0	3	3	3	2	0	2	4	2	0	2	5	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:124285882G>A	uc001uft.3	+	15	2188	c.2163G>A	c.(2161-2163)ACG>ACA	p.T721T	DNAH10_uc010tav.1_Silent_p.T263T|DNAH10_uc010taw.1_Silent_p.T206T	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	721	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCATAGGAACGTTAAACGATG	0.463													69	164					0	0	0	0	A	124285882	A	A	124285882	2	1	79	1	0	0	0	0	0	0	0	1	4620	1132	40	1		1	DNAH10	12	124285882	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	17278	124285882	9566013	58	15906											
PIWIL1	9271	broad.mit.edu	37	chr12	130827639	130827639	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcaggaggaacagccaaGtcacaaggtgaagagaaagt	18	3	13	7	0	1	2	1	1	0	1	1	5	1	4	1	3	3	1	1	3	5	0			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr12:130827639G>A	uc001uik.2	+	3	273	c.183G>A	c.(181-183)AAG>AAA	p.K61K	PIWIL1_uc001uij.1_Silent_p.K61K	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	61					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GAACAGCCAAGTCACAAGGTG	0.438													9	14					0	0	0	0	A	130827639	A	A	130827639	2	1	79	1	0	0	0	0	0	0	0	1	12012	1020	36	4		4	PIWIL1	12	130827639	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	6541757	130827639	3024256	59	15907											
ARL11	115761	broad.mit.edu	37	chr13	50204602	50204602	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgggttctgtgaattccAgaggtcacaaggcggaagcc	10	8	13	10	1	2	2	1	1	1	1	3	3	3	3	3	4	1	1	3	4	3	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr13:50204602A>G	uc001vdf.1	+	2	165	c.19A>G	c.(19-21)AGA>GGA	p.R7G		NM_138450	NP_612459	Q969Q4	ARL11_HUMAN	ADP-ribosylation factor-like 11	7					small GTPase mediated signal transduction	intracellular	GTP binding|protein binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.119)|Kidney(9;0.169)	GBM - Glioblastoma multiforme(99;1.67e-09)		TGTGAATTCCAGAGGTCACAA	0.557													13	106					0	0	0	0	G	50204602	G	G	50204602	3	3	79	1	0	0	0	0	1	0	0	0	927	180	7	5	21	5	ARL11	13	50204602	Missense_Mutation	SNP	A	TCGA-CN-6022-01A-21D-1683-08		50204602	64965276	60	15908											
LIG4	3981	broad.mit.edu	37	chr13	108861732	108861732	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcatctttggggcagcttTccgctttttttcttgtggtt	2	21	9	9	1	3	0	1	0	2	0	4	0	4	0	1	3	1	4	1	3	0	8			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr13:108861732T>A	uc001vqn.2	-	2	2158	c.1885A>T	c.(1885-1887)AAA>TAA	p.K629*	LIG4_uc001vqo.2_Nonsense_Mutation_p.K629*|LIG4_uc010agg.1_Nonsense_Mutation_p.K562*|LIG4_uc010agf.2_Nonsense_Mutation_p.K629*|LIG4_uc001vqp.2_Nonsense_Mutation_p.K629*	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	629					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					GGGGCAGCTTTCCGCTTTTTT	0.383								NHEJ					22	51					0	0	0	0	A	108861732	A	A	108861732	4	1	79	1	0	0	0	0	0	1	0	0	8824	1792	62	5	854	5	LIG4	13	108861732	Nonsense_Mutation	SNP	T	TCGA-CN-6022-01A-21D-1683-08	58657130	108861732	6308146	61	15909											
COL4A1	1282	broad.mit.edu	37	chr13	110829000	110829000	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggctgtcctgcctgccCgtcctttccaggcactcctg	3	10	9	19	1	0	0	0	0	0	0	4	0	4	0	7	2	2	2	7	2	0	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr13:110829000C>G	uc001vqw.3	-	35	3063	c.2941G>C	c.(2941-2943)GGG>CGG	p.G981R	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	981	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTGCCTGCCCGTCCTTTCCA	0.577													15	43					0	0	0	0	G	110829000	G	G	110829000	3	3	79	1	0	0	0	0	1	0	0	0	3704	652	23	3	2140	3	COL4A1	13	110829000	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	1967268	110829000	4340878	62	15910											
KIAA0247	9766	broad.mit.edu	37	chr14	70175519	70175519	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgccacctgctgaccccaGagtacagattgtgctgtcag	8	10	11	12	0	1	3	1	1	0	2	1	3	1	3	4	0	4	3	4	0	1	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr14:70175519G>C	uc001xlk.2	+	5	900	c.584G>C	c.(583-585)AGA>ACA	p.R195T	KIAA0247_uc010aqz.2_Missense_Mutation_p.R170T	NM_014734	NP_055549	Q92537	K0247_HUMAN	hypothetical protein LOC9766 precursor	195	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3				all cancers(60;0.00155)|BRCA - Breast invasive adenocarcinoma(234;0.0164)|OV - Ovarian serous cystadenocarcinoma(108;0.0196)		GCTGACCCCAGAGTACAGATT	0.592													18	89					0	0	0	0	C	70175519	C	C	70175519	3	2	79	1	0	0	0	0	1	0	0	0	8204	942	33	2	598	2	KIAA0247	14	70175519	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08		70175519	37174021	63	15911											
C14orf79	122616	broad.mit.edu	37	chr14	105457937	105457937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaacttctttcttgttctcGgaatagatgctgcgcagaag	10	13	10	8	2	3	3	0	0	3	3	4	4	3	4	0	1	3	3	0	1	4	5			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr14:105457937G>A	uc001ypy.1	+	3	832	c.679G>A	c.(679-681)GGA>AGA	p.G227R	C14orf79_uc001ypz.1_RNA|C14orf79_uc010tym.1_RNA	NM_174891	NP_777551	Q96F83	CN079_HUMAN	hypothetical protein LOC122616	227											0		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00326)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0181)			TCTTGTTCTCGGAATAGATGC	0.562													42	70					0	0	0	0	A	105457937	A	A	105457937	3	1	79	1	0	0	0	0	1	0	0	0	1786	1117	39	1	689	1	C14orf79	14	105457937	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	35282418	105457937	1891603	64	15912											
APBA2	321	broad.mit.edu	37	chr15	29390768	29390768	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaggatcaaggttttaaatGcagacacgcaggtaagcgtt	14	9	12	6	2	1	2	1	0	0	2	1	3	1	3	0	3	2	5	0	3	4	4			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:29390768G>T	uc001zck.2	+	8	1534	c.1327G>T	c.(1327-1329)GCA>TCA	p.A443S	APBA2_uc010azj.2_Missense_Mutation_p.A431S|APBA2_uc010uat.1_Missense_Mutation_p.A431S|APBA2_uc001zcl.2_Missense_Mutation_p.A431S|APBA2_uc001zcm.1_Missense_Mutation_p.A135S	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	443	PID.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGTTTTAAATGCAGACACGCA	0.468													7	50					0.00198382	0.00210051	1	0	T	29390768	T	T	29390768	3	4	79	1	0	0	0	0	1	0	0	0	757	1319	46	4	1349	4	APBA2	15	29390768	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08		29390768	73140624	65	15913											
ARHGAP11A	9824	broad.mit.edu	37	chr15	32921801	32921801	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgatattttttcagcccagCtatctgaatcaccagtgatt	10	16	6	9	0	3	3	2	3	1	0	3	3	3	3	2	0	2	1	2	0	3	7			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:32921801C>T	uc001zgy.1	+	8	1665	c.943C>T	c.(943-945)CTA>TTA	p.L315L	ARHGAP11A_uc010ubw.1_Silent_p.L126L|ARHGAP11A_uc001zgw.2_Silent_p.L315L|ARHGAP11A_uc001zgx.2_Silent_p.L315L|ARHGAP11A_uc010ubx.1_Silent_p.L126L	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	315					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TTCAGCCCAGCTATCTGAATC	0.343													9	84					0	0	0	0	T	32921801	T	T	32921801	2	4	79	1	0	0	0	0	0	0	0	1	863	796	28	4		4	ARHGAP11A	15	32921801	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08	3531033	32921801	69609591	66	15914											
UBL7	84993	broad.mit.edu	37	chr15	74738533	74738533	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcgtcctggatgcccatGtcacgtagctgctgcagctg	6	11	11	13	2	2	0	2	0	0	0	4	1	3	1	2	1	5	5	2	1	1	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:74738533G>A	uc002axw.1	-	11	1203	c.1041C>T	c.(1039-1041)GAC>GAT	p.D347D	UBL7_uc002axx.1_Silent_p.D387D|UBL7_uc010bjr.1_Silent_p.D238D|UBL7_uc002axy.1_Silent_p.D347D|UBL7_uc002axz.1_Silent_p.D347D	NM_032907	NP_116296	Q96S82	UBL7_HUMAN	ubiquitin-like 7	347	UBA.						protein binding			ovary(1)	1						GGATGCCCATGTCACGTAGCT	0.602													17	89					0	0	0	0	A	74738533	A	A	74738533	2	1	79	1	0	0	0	0	0	0	0	1	16958	1368	48	4		4	UBL7	15	74738533	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	41816732	74738533	27792859	67	15915											
ZSCAN2	54993	broad.mit.edu	37	chr15	85164982	85164982	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcgctcccagctcgtagTgcaccagcggacccacacgg	8	4	11	18	4	0	0	0	0	0	0	2	1	1	1	4	2	4	4	4	2	1	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:85164982T>C	uc002bkr.2	+	3	1782	c.1556T>C	c.(1555-1557)GTG>GCG	p.V519A	ZSCAN2_uc010bmz.1_Missense_Mutation_p.V517A|ZSCAN2_uc010bna.2_Missense_Mutation_p.V369A|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	519	C2H2-type 11.				cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		CAGCTCGTAGTGCACCAGCGG	0.592													30	147					0	0	0	0	C	85164982	C	C	85164982	3	2	79	1	0	0	0	0	1	0	0	0	18298	1696	59	5	1652	5	ZSCAN2	15	85164982	Missense_Mutation	SNP	T	TCGA-CN-6022-01A-21D-1683-08	10426449	85164982	17366410	68	15916											
KLHL25	64410	broad.mit.edu	37	chr15	86312285	86312285	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctgccatgaggagggcctCgctggagacggcctcctgca	6	7	15	13	2	1	2	0	1	1	1	3	4	2	3	4	4	2	2	4	4	0	0			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr15:86312285C>T	uc002bly.2	-	2	960	c.757G>A	c.(757-759)GAG>AAG	p.E253K		NM_022480	NP_071925	Q9H0H3	ENC2_HUMAN	BTB/POZ KELCH domain protein	253						cytoplasm				ovary(2)	2						AGGAGGGCCTCGCTGGAGACG	0.657													8	23					0	0	0	0	T	86312285	T	T	86312285	3	4	79	1	0	0	0	0	1	0	0	0	8419	893	31	1	1016	1	KLHL25	15	86312285	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	1147303	86312285	16219107	69	15917											
TMEM8A	58986	broad.mit.edu	37	chr16	426289	426289	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacgtccatgtcctcccgCgtgactgggtagtttgtgag	6	11	12	12	3	0	2	0	2	0	0	3	2	3	2	4	1	0	2	4	1	1	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr16:426289C>T	uc002cgu.3	-	6	1200	c.1071G>A	c.(1069-1071)ACG>ACA	p.T357T	TMEM8A_uc002cgv.3_Silent_p.T164T	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	357	Extracellular (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3						TGTCCTCCCGCGTGACTGGGT	0.672													31	74					0	0	0	0	T	426289	T	T	426289	2	4	79	1	0	0	0	0	0	0	0	1	16280	755	27	1		1	TMEM8A	16	426289	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08		426289	89928464	70	15918											
GRIN2A	2903	broad.mit.edu	37	chr16	9857175	9857175	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccctggaacagtacgatGccgttgacctcaaggacgac	10	8	11	12	3	1	1	1	1	0	0	2	5	2	3	3	2	3	2	3	2	3	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr16:9857175G>A	uc002czo.3	-	13	4774	c.4226C>T	c.(4225-4227)GCA>GTA	p.A1409V	GRIN2A_uc010uym.1_Missense_Mutation_p.A1409V|GRIN2A_uc010uyn.1_3'UTR|GRIN2A_uc002czr.3_3'UTR	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1409	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACAGTACGATGCCGTTGACCT	0.502													19	41					0	0	0	0	A	9857175	A	A	9857175	3	1	79	1	0	0	0	0	1	0	0	0	6818	1319	46	4	172	4	GRIN2A	16	9857175	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	9430886	9857175	80497578	71	15919											
CNGB1	1258	broad.mit.edu	37	chr16	57994804	57994804	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctgctccagccacagaagCagccgcagcccaggcctgca	9	5	10	17	1	1	1	0	0	1	1	2	1	2	1	5	1	6	4	5	1	1	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr16:57994804C>T	uc002emt.2	-	8	539	c.474G>A	c.(472-474)CTG>CTA	p.L158L	CNGB1_uc010cdh.2_Silent_p.L158L|CNGB1_uc002emu.2_Silent_p.L158L	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	158					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GCCACAGAAGCAGCCGCAGCC	0.622													3	22					0	0	0	0	T	57994804	T	T	57994804	2	4	79	1	0	0	0	0	0	0	0	1	3615	697	25	4		4	CNGB1	16	57994804	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08	48137629	57994804	32359949	72	15920											
DPEP3	64180	broad.mit.edu	37	chr16	68011733	68011733	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaactcctctactactttCtgcagaaacaattaggtttt	11	16	4	10	0	3	1	1	0	2	1	4	1	4	1	1	1	5	2	1	1	6	7			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr16:68011733C>G	uc002evc.3	-	6	926	c.832_splice	c.e6-1	p.K278_splice	DPEP3_uc010cex.2_Splice_Site_p.K278_splice	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a						meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		CTACTACTTTCTGCAGAAACA	0.498													3	24					0	0	0	0	G	68011733	G	G	68011733	5	3	79	1	0	0	0	0	0	0	1	0	4737	927	32	2	730	2	DPEP3	16	68011733	Splice_Site	SNP	C	TCGA-CN-6022-01A-21D-1683-08	10016929	68011733	22343020	73	15921											
HYDIN	54768	broad.mit.edu	37	chr16	70926425	70926425	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaatccctacagagtccaCggaaaagctgaaagacaaga	18	5	9	9	1	0	5	0	2	0	3	2	6	2	6	2	1	2	1	2	1	6	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr16:70926425C>A	uc002ezr.2	-	56	9381	c.9253G>T	c.(9253-9255)GTG>TTG	p.V3085L		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3086										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ACAGAGTCCACGGAAAAGCTG	0.453													9	53					7.48243e-07	8.50634e-07	1	0	A	70926425	A	A	70926425	3	1	79	1	0	0	0	0	1	0	0	0	7506	536	19	3	6233	3	HYDIN	16	70926425	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	2914692	70926425	19428328	74	15922											
ITGAE	3682	broad.mit.edu	37	chr17	3661071	3661071	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgtaaggttgagggggtcctCgaatatgccaccatcggtga	9	9	14	9	3	0	2	0	2	0	0	3	3	1	2	3	4	1	2	3	4	3	3	rs143543471		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:3661071C>G	uc002fwo.3	-	9	1048	c.949G>C	c.(949-951)GAG>CAG	p.E317Q		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	317	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		AGGGGGTCCTCGAATATGCCA	0.562													33	239					0	0	0	0	G	3661071	G	G	3661071	3	3	79	1	0	0	0	0	1	0	0	0	7924	893	31	3	2682	3	ITGAE	17	3661071	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08		3661071	77534139	75	15923											
TP53	7157	broad.mit.edu	37	chr17	7577498	7577498	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtggcaagtggctcctgaCctggagtcttccagtgtgat	6	11	15	9	0	1	2	0	2	1	0	3	3	3	3	3	4	0	2	3	4	1	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:7577498C>T	uc002gim.2	-	7	976	c.782_splice	c.e7+1	p.S261_splice	TP53_uc002gig.1_Splice_Site_p.R261_splice|TP53_uc002gih.2_Splice_Site_p.S261_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.S129_splice|TP53_uc010cng.1_Splice_Site_p.S129_splice|TP53_uc002gii.1_Splice_Site_p.S129_splice|TP53_uc010cnh.1_Splice_Site_p.S261_splice|TP53_uc010cni.1_Splice_Site_p.S261_splice|TP53_uc002gij.2_Splice_Site_p.S261_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(25)|p.0?(7)|p.E258fs*71(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGCTCCTGACCTGGAGTCTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	30					0	0	0	0	T	7577498	T	T	7577498	5	4	79	1	0	0	0	0	0	0	1	0	16448	521	18	4	507	4	TP53	17	7577498	Splice_Site	SNP	C	TCGA-CN-6022-01A-21D-1683-08	3916427	7577498	73617712	76	15924											
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	6	8	16	11	2	1	1	1	1	0	0	2	3	2	2	4	5	2	2	4	5	0	1	rs121912651		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	44					0	0	0	0	A	7577539	A	A	7577539	3	1	79	1	0	0	0	0	1	0	0	0	16448	1115	39	1	548	1	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	41	7577539	73617671	77	15925											
ABCA6	23460	broad.mit.edu	37	chr17	67092867	67092867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattaaaatgaagaagctgaCgtccactagtgcctgcccac	14	8	8	11	1	0	3	0	2	0	1	1	3	1	3	3	0	3	1	3	0	6	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:67092867C>T	uc002jhw.1	-	24	3371	c.3196G>A	c.(3196-3198)GTC>ATC	p.V1066I		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1066	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					AAGAAGCTGACGTCCACTAGT	0.353													6	19					0	0	0	0	T	67092867	T	T	67092867	3	4	79	1	0	0	0	0	1	0	0	0	36	536	19	1	1721	1	ABCA6	17	67092867	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	59515328	67092867	14102343	78	15926											
OTOP2	92736	broad.mit.edu	37	chr17	72927021	72927021	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccttcaccgaggaccgcccGgggctgagcctcacagtacc	7	5	12	17	3	2	1	2	1	0	0	2	3	2	2	6	3	2	2	6	3	1	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:72927021G>T	uc010wrp.1	+	7	1380	c.1291G>T	c.(1291-1293)GGG>TGG	p.G431W		NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	431						integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					AGGACCGCCCGGGGCTGAGCC	0.622													7	97					1.06961e-07	1.24213e-07	1	0	T	72927021	T	T	72927021	3	4	79	1	0	0	0	0	1	0	0	0	11360	1116	39	3	1309	3	OTOP2	17	72927021	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	5834154	72927021	8268189	79	15927											
QRICH2	84074	broad.mit.edu	37	chr17	74287585	74287585	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgatgccacatgctgttGatctgggtgtgtagatccca	8	12	13	8	0	1	3	0	2	1	1	2	3	2	3	2	2	2	3	2	2	1	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr17:74287585G>A	uc002jrd.1	-	4	2905	c.2725C>T	c.(2725-2727)CAA>TAA	p.Q909*	QRICH2_uc010wsz.1_Nonsense_Mutation_p.Q835*|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	909							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						ACATGCTGTTGATCTGGGTGT	0.512													14	122					0	0	0	0	A	74287585	A	A	74287585	4	1	79	1	0	0	0	0	0	1	0	0	12945	1299	45	2	2330	2	QRICH2	17	74287585	Nonsense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	1360564	74287585	6907625	80	15928											
CEP76	79959	broad.mit.edu	37	chr18	12697408	12697408	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccattctagttccatcacCtagcaatataatccaaacga	15	10	4	12	1	2	0	1	0	1	0	4	1	4	0	4	0	3	2	4	0	6	6			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr18:12697408C>T	uc002kri.2	-	5	677	c.521_splice	c.e5-1	p.G174_splice	PSMG2_uc002krg.2_Intron|CEP76_uc002krh.3_Splice_Site|CEP76_uc010wzz.1_Splice_Site_p.S99_splice|CEP76_uc010xaa.1_Splice_Site	NM_024899	NP_079175	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa						G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding				0						GTTCCATCACCTAGCAATATA	0.299													18	52					0	0	0	0	T	12697408	T	T	12697408	5	4	79	1	0	0	0	0	0	0	1	0	3276	695	24	4	1491	4	CEP76	18	12697408	Splice_Site	SNP	C	TCGA-CN-6022-01A-21D-1683-08		12697408	65379840	81	15929											
PRKACA	5566	broad.mit.edu	37	chr19	14211687	14211687	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacatctccccgccgggcaCgtactccatgaccatgtata	10	8	8	15	3	1	1	0	1	1	0	3	2	2	1	5	1	2	3	5	1	4	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:14211687C>T	uc002myc.2	-	5	570	c.370G>A	c.(370-372)GTG>ATG	p.V124M	PRKACA_uc002myb.2_Missense_Mutation_p.V116M|PRKACA_uc010xnm.1_Missense_Mutation_p.V66M|PRKACA_uc002myd.2_Missense_Mutation_p.V66M	NM_002730	NP_002721	P17612	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit	124	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1						CCGCCGGGCACGTACTCCATG	0.602													11	52					0	0	0	0	T	14211687	T	T	14211687	3	4	79	1	0	0	0	0	1	0	0	0	12559	536	19	1	709	1	PRKACA	19	14211687	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08		14211687	44917296	82	15930											
IL12RB1	3594	broad.mit.edu	37	chr19	18194250	18194250	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actgccccgaacctgagtctGcatccggatatggcgggtcc	7	8	12	14	3	1	1	0	1	1	0	3	3	3	2	5	3	3	1	5	3	2	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:18194250G>A	uc002nhw.1	-	2	180	c.116C>T	c.(115-117)GCA>GTA	p.A39V	IL12RB1_uc010xqb.1_Missense_Mutation_p.A39V|IL12RB1_uc002nhx.1_Missense_Mutation_p.A79V|IL12RB1_uc002nhy.2_Missense_Mutation_p.A39V	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	39	Extracellular (Potential).				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						ACCTGAGTCTGCATCCGGATA	0.567													4	107					0	0	0	0	A	18194250	A	A	18194250	3	1	79	1	0	0	0	0	1	0	0	0	7665	1319	46	4	2065	4	IL12RB1	19	18194250	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	3982563	18194250	40934733	83	15931											
ZNF737	100129842	broad.mit.edu	37	chr19	20728189	20728189	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtatgaattatcttatgtgTagtaaggttagaggagcgct	12	14	12	3	1	1	2	0	1	1	1	1	3	1	3	0	2	1	5	0	2	7	6	rs57947174	by1000genomes	TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:20728189T>G	uc002npa.2	-	4	1000	c.820A>C	c.(820-822)ACA>CCA	p.T274P		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	274					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						ATCTTATGTGTAGTAAGGTTA	0.398													4	19					0	0	0	0	G	20728189	G	G	20728189	3	3	79	1	0	0	0	0	1	0	0	0	18193	1638	57	5	794	5	ZNF737	19	20728189	Missense_Mutation	SNP	T	TCGA-CN-6022-01A-21D-1683-08	2533939	20728189	38400794	84	15932											
RYR1	6261	broad.mit.edu	37	chr19	39010003	39010003	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccaaggcggaggcccaggagGgcgagctgctggtgcgggac	7	3	20	11	3	0	0	0	0	0	0	0	4	0	3	2	7	3	2	2	7	1	0			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:39010003G>T	uc002oit.2	+	67	10298	c.10168G>T	c.(10168-10170)GGC>TGC	p.G3390C	RYR1_uc002oiu.2_Missense_Mutation_p.G3390C|RYR1_uc002oiv.1_Missense_Mutation_p.G310C|RYR1_uc010xuf.1_Missense_Mutation_p.G310C	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3390					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCCCAGGAGGGCGAGCTGCT	0.662													6	20					0.00116845	0.00124943	1	0	T	39010003	T	T	39010003	3	4	79	1	0	0	0	0	1	0	0	0	13833	1232	43	4	10434	4	RYR1	19	39010003	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	18281814	39010003	20118980	85	15933											
HNRNPUL1	11100	broad.mit.edu	37	chr19	41782195	41782195	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaggggccgtgtatgcttcGagatgaaggtgagtaggagc	10	8	18	5	2	0	3	0	2	0	1	1	6	0	4	1	4	2	3	1	4	4	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:41782195G>A	uc002oqb.3	+	5	1067	c.778G>A	c.(778-780)GAG>AAG	p.E260K	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Missense_Mutation_p.E160K|HNRNPUL1_uc002oqa.3_Missense_Mutation_p.E160K|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.E260K|HNRNPUL1_uc002oqc.3_Missense_Mutation_p.E217K|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Missense_Mutation_p.E160K|HNRNPUL1_uc010ehn.2_Missense_Mutation_p.E160K|HNRNPUL1_uc010eho.2_Missense_Mutation_p.E160K|HNRNPUL1_uc010xvy.1_Missense_Mutation_p.E160K|HNRNPUL1_uc010ehp.2_Missense_Mutation_p.E116K|HNRNPUL1_uc010ehl.1_Missense_Mutation_p.E160K	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	260	B30.2/SPRY.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						TGTATGCTTCGAGATGAAGGT	0.532													12	88					0	0	0	0	A	41782195	A	A	41782195	3	1	79	1	0	0	0	0	1	0	0	0	7313	1059	37	1	796	1	HNRNPUL1	19	41782195	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	2772192	41782195	17346788	86	15934											
PPFIA3	8541	broad.mit.edu	37	chr19	49631304	49631304	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttggctacagcgcagctGcggctgcgcgagctcggcca	5	6	17	13	5	0	0	0	0	0	0	1	1	0	0	1	4	6	6	1	4	1	2			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr19:49631304G>A	uc002pmr.2	+	2	506	c.174G>A	c.(172-174)CTG>CTA	p.L58L	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010emt.2_5'Flank|PPFIA3_uc010yaj.1_5'Flank|PPFIA3_uc002pms.2_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	58	Potential.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CAGCGCAGCTGCGGCTGCGCG	0.726													10	13					0	0	0	0	A	49631304	A	A	49631304	2	1	79	1	0	0	0	0	0	0	0	1	12366	1306	46	4		4	PPFIA3	19	49631304	Silent	SNP	G	TCGA-CN-6022-01A-21D-1683-08	7849109	49631304	9497679	87	15935											
OVOL2	58495	broad.mit.edu	37	chr20	18022341	18022341	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcacagctgtgaaccacCgagtcgctgcacgtgcctgt	8	8	12	13	3	1	1	1	1	0	0	2	2	1	1	3	1	4	3	3	1	1	0			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr20:18022341C>A	uc002wqi.1	-	3	591	c.348G>T	c.(346-348)TCG>TCT	p.S116S		NM_021220	NP_067043	Q9BRP0	OVOL2_HUMAN	zinc finger protein 339	116					negative regulation of keratinocyte differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription by competitive promoter binding|regulation of cell cycle|regulation of keratinocyte proliferation|transcription, DNA-dependent	nucleus	DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1						TGTGAACCACCGAGTCGCTGC	0.612													10	28					0.000673444	0.00072732	1	0	A	18022341	A	A	18022341	2	1	79	1	0	0	0	0	0	0	0	1	11381	639	23	3		3	OVOL2	20	18022341	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08		18022341	45003179	88	15936											
LSS	4047	broad.mit.edu	37	chr21	47635094	47635094	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgggcaggggcactgacCgggccgatgctgatgctctt	5	7	17	12	3	1	2	0	2	1	0	1	3	1	2	3	5	2	4	3	5	0	1			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr21:47635094C>T	uc002zij.2	-	9	1090	c.1011G>A	c.(1009-1011)CCG>CCA	p.P337P	LSS_uc011afv.1_Silent_p.P326P|LSS_uc002zil.2_Silent_p.P337P|LSS_uc002zik.2_Silent_p.P257P	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	337					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					GGGCACTGACCGGGCCGATGC	0.642													7	67					0	0	0	0	T	47635094	T	T	47635094	2	4	79	1	0	0	0	0	0	0	0	1	9115	666	23	1		1	LSS	21	47635094	Silent	SNP	C	TCGA-CN-6022-01A-21D-1683-08		47635094	494801	89	15937											
PCNT	5116	broad.mit.edu	37	chr21	47863774	47863774	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaccagagagtccccccCaacccgggatgtaccctctg	10	5	9	17	1	1	2	0	0	1	2	2	4	2	3	6	1	3	1	6	1	3	1	rs138097697		TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr21:47863774C>G	uc002zji.3	+	45	9859	c.9752C>G	c.(9751-9753)CCA>CGA	p.P3251R	PCNT_uc002zjj.2_Missense_Mutation_p.P3054R	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	3251					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GAGTCCCCCCCAACCCGGGAT	0.592													40	73					0	0	0	0	G	47863774	G	G	47863774	3	3	79	1	0	0	0	0	1	0	0	0	11644	594	21	4	9930	4	PCNT	21	47863774	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08	228680	47863774	266121	90	15938											
RFPL3	10738	broad.mit.edu	37	chr22	32756682	32756682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtctatacattcaggagcGtctctgctgaggagccactg	9	11	11	10	1	3	1	1	1	2	0	4	3	3	3	1	2	4	1	1	2	2	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chr22:32756682G>A	uc003amj.2	+	2	1022	c.817G>A	c.(817-819)GTC>ATC	p.V273I	RFPL3_uc010gwn.2_Missense_Mutation_p.V244I|RFPL3S_uc003amk.2_RNA|RFPL3S_uc003aml.2_RNA	NM_001098535	NP_001092005	O75679	RFPL3_HUMAN	ret finger protein-like 3 isoform 1	273	B30.2/SPRY.						zinc ion binding			ovary(1)	1						ATTCAGGAGCGTCTCTGCTGA	0.483													14	47					0	0	0	0	A	32756682	A	A	32756682	3	1	79	1	0	0	0	0	1	0	0	0	13320	1145	40	1	823	1	RFPL3	22	32756682	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08		32756682	18547884	91	15939											
PNPLA4	8228	broad.mit.edu	37	chrX	7868777	7868777	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttaacagtgtcatcaaaacCacactgatacaaagattcca	17	9	4	11	0	2	2	2	1	0	1	3	2	3	2	2	0	3	0	2	0	5	3			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chrX:7868777C>T	uc011mhq.1	-	7	874	c.712G>A	c.(712-714)GGT>AGT	p.G238S	PNPLA4_uc011mhr.1_Missense_Mutation_p.G238S|PNPLA4_uc011mhs.1_Missense_Mutation_p.G151S	NM_004650	NP_004641	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	238					lipid catabolic process		triglyceride lipase activity				0		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				TCATCAAAACCACACTGATAC	0.343													5	10					0	0	0	0	T	7868777	T	T	7868777	3	4	79	1	0	0	0	0	1	0	0	0	12222	594	21	4	53	4	PNPLA4	23	7868777	Missense_Mutation	SNP	C	TCGA-CN-6022-01A-21D-1683-08		7868777	147401783	92	15940											
YY2	404281	broad.mit.edu	37	chrX	21875473	21875473	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatgtgcagaatgtggcaaaGcttttcttgagagctcaaag	12	12	11	6	0	2	2	1	1	1	2	2	3	2	2	0	1	3	4	0	1	4	4			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chrX:21875473G>C	uc011mjp.1	+	1	871	c.871G>C	c.(871-873)GCT>CCT	p.A291P	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Missense_Mutation_p.A509P|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	291	Mediates transcriptional repression.|C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						ATGTGGCAAAGCTTTTCTTGA	0.537													52	82					0	0	0	0	C	21875473	C	C	21875473	3	2	79	1	0	0	0	0	1	0	0	0	17577	971	34	4	873	4	YY2	23	21875473	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	14006696	21875473	133395087	93	15941											
IGSF1	3547	broad.mit.edu	37	chrX	130409627	130409627	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtggcttctccttctttGtgcagaatgtatcctactcc	7	15	8	11	0	2	1	0	0	2	1	5	2	4	1	3	1	2	3	3	1	4	5			TCGA-CN-6022-01A-21D-1683-08	TCGA-CN-6022-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	90cd2296-7133-4cbe-99cb-84b084eb88cd	9d1d3ad1-bcca-4d02-81e3-0807015fdd83	g.chrX:130409627G>T	uc004ewd.2	-	16	3247	c.3009C>A	c.(3007-3009)CAC>CAA	p.H1003Q	IGSF1_uc004ewe.3_Missense_Mutation_p.H997Q|IGSF1_uc004ewf.2_Missense_Mutation_p.H983Q	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1003	Extracellular (Potential).|Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CTCCTTCTTTGTGCAGAATGT	0.527													8	34					5.68852e-11	6.90293e-11	1	0	T	130409627	T	T	130409627	3	4	79	1	0	0	0	0	1	0	0	0	7635	1368	48	4	1021	4	IGSF1	23	130409627	Missense_Mutation	SNP	G	TCGA-CN-6022-01A-21D-1683-08	108534154	130409627	24860933	94	15942											
AGRN	375790	broad.mit.edu	37	chr1	982024	982024	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcccctgcacccagcctggtGgcgtccgcctttggtgaatc	4	10	11	16	2	0	1	0	1	0	0	3	1	2	1	6	3	2	1	6	3	1	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:982024G>A	uc001ack.1	+	18	3209	c.3159G>A	c.(3157-3159)GTG>GTA	p.V1053V		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	1053	Ser/Thr-rich.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CCAGCCTGGTGGCGTCCGCCT	0.687													11	10					0	0	0	0	A	982024	A	A	982024	2	1	80	1	0	0	0	0	0	0	0	1	397	1335	47	4		4	AGRN	1	982024	Silent	SNP	G	TCGA-CN-6023-01A-11D-1683-08		982024	248268597	1	15943											
NMNAT1	64802	broad.mit.edu	37	chr1	10042404	10042404	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggggcagatttattggagtCctttgctgttcccaatttgt	6	17	11	7	0	0	1	0	0	0	1	2	2	2	2	2	3	1	3	2	3	2	6			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:10042404C>T	uc001aqp.2	+	5	629	c.485C>T	c.(484-486)TCC>TTC	p.S162F		NM_022787	NP_073624	Q9HAN9	NMNA1_HUMAN	nicotinamide mononucleotide adenylyltransferase	162					water-soluble vitamin metabolic process	nucleoplasm	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding				0		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.31e-08)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(185;0.00028)|BRCA - Breast invasive adenocarcinoma(304;0.00032)|KIRC - Kidney renal clear cell carcinoma(229;0.00101)|STAD - Stomach adenocarcinoma(132;0.00908)|READ - Rectum adenocarcinoma(331;0.0419)		TTATTGGAGTCCTTTGCTGTT	0.478													24	87					0	0	0	0	T	10042404	T	T	10042404	3	4	80	1	0	0	0	0	1	0	0	0	10552	855	30	2	499	2	NMNAT1	1	10042404	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	9060380	10042404	239208217	2	15944											
ZMYM6	9204	broad.mit.edu	37	chr1	35476586	35476586	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttacaaccacttggccctGagacaggggcaccgccgaag	10	5	12	14	2	0	1	0	1	0	1	0	3	0	1	4	3	2	2	4	3	3	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:35476586G>A	uc001byh.2	-	9	1342	c.1114C>T	c.(1114-1116)CAG>TAG	p.Q372*	ZMYM6_uc001byf.1_Nonsense_Mutation_p.Q372*|ZMYM6_uc010oht.1_Nonsense_Mutation_p.Q275*|ZMYM6_uc009vup.2_Nonsense_Mutation_p.Q178*|ZMYM6_uc009vuq.1_Nonsense_Mutation_p.Q372*|ZMYM6_uc009vur.1_Nonsense_Mutation_p.Q178*	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	372	MYM-type 5.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				ACTTGGCCCTGAGACAGGGGC	0.488													12	48					0	0	0	0	A	35476586	A	A	35476586	4	1	80	1	0	0	0	0	0	1	0	0	17771	1299	45	2	2895	2	ZMYM6	1	35476586	Nonsense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	25434182	35476586	213774035	3	15945											
MYSM1	114803	broad.mit.edu	37	chr1	59147830	59147830	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctgtttctcagtccacaGtgtaatttctgagcttgaaa	9	15	8	9	0	3	2	1	2	3	0	5	2	4	2	1	0	1	4	1	0	2	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:59147830G>A	uc009wab.1	-	8	909	c.886C>T	c.(886-888)CTG>TTG	p.L296L	MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	296					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TCAGTCCACAGTGTAATTTCT	0.363													13	109					0	0	0	0	A	59147830	A	A	59147830	2	1	80	1	0	0	0	0	0	0	0	1	10154	1020	36	4		4	MYSM1	1	59147830	Silent	SNP	G	TCGA-CN-6023-01A-11D-1683-08	23671244	59147830	190102791	4	15946											
NBPF10	100132406	broad.mit.edu	37	chr1	145293516	145293516	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagaaacagcagttcagaaaCctcaaagagaaatgttttct	18	9	7	7	0	3	3	2	0	1	3	3	4	3	3	1	0	3	3	1	0	5	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:145293516C>A	uc001end.3	+	1	146	c.111C>A	c.(109-111)AAC>AAA	p.N37K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.N37K|NOTCH2NL_uc010oyh.1_RNA|NBPF10_uc001emq.1_Missense_Mutation_p.N37K	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	37											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGTTCAGAAACCTCAAAGAGA	0.478													6	474					1.58986e-06	1.73339e-06	1	0	A	145293516	A	A	145293516	3	1	80	1	0	0	0	0	1	0	0	0	10246	506	18	4	113	4	NBPF10	1	145293516	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	86145686	145293516	103957105	5	15947											
NBPF10	100132406	broad.mit.edu	37	chr1	145299875	145299875	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagaaacagcagttcagaaaCctcaaagagaaatgttttct	18	9	7	7	0	3	3	2	0	1	3	3	4	3	3	1	0	3	3	1	0	5	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:145299875C>A	uc001end.3	+	6	959	c.924C>A	c.(922-924)AAC>AAA	p.N308K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.N308K|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	308											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGTTCAGAAACCTCAAAGAGA	0.458													37	369					6.4308e-24	7.64876e-24	1	0	A	145299875	A	A	145299875	3	1	80	1	0	0	0	0	1	0	0	0	10246	506	18	4	946	4	NBPF10	1	145299875	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	6359	145299875	103950746	6	15948											
RHBG	57127	broad.mit.edu	37	chr1	156337539	156337539	+	5'Flank	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacacgggatgcttacactgCcaggctcggtctatgttggt	7	11	12	11	2	1	0	0	0	1	0	2	1	1	1	1	4	3	3	1	4	2	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:156337539C>A	uc010pho.1	+						RHBG_uc010phm.1_5'Flank|RHBG_uc010phn.1_5'Flank|RHBG_uc001fos.2_5'Flank|RHBG_uc009wrz.2_5'Flank|RHBG_uc001for.2_5'Flank	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein						transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					gcttacactgccaggctcggt	0													14	79					6.31663e-08	7.08365e-08	1	0	A	156337539	A	A	156337539	1	1	80	0	1	0	0	0	0	0	0	0	13389	754	26	4		4	RHBG	1	156337539	5'Flank	SNP	C	TCGA-CN-6023-01A-11D-1683-08	11037664	156337539	92913082	7	15949											
ADIPOR1	51094	broad.mit.edu	37	chr1	202915728	202915728	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgggatgaccctccaacgtCcctcccagacctagaacata	12	7	7	15	1	0	3	0	1	0	2	3	4	3	4	5	1	2	0	5	1	4	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:202915728C>T	uc001gyq.3	-	4	536	c.269G>A	c.(268-270)GGA>GAA	p.G90E	ADIPOR1_uc010pqd.1_Missense_Mutation_p.G14E|ADIPOR1_uc001gyr.3_5'UTR|ADIPOR1_uc001gys.3_Missense_Mutation_p.G90E	NM_015999	NP_057083	Q96A54	ADR1_HUMAN	adiponectin receptor 1	90	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity				0			BRCA - Breast invasive adenocarcinoma(75;0.141)			CCTCCAACGTCCCTCCCAGAC	0.502													9	44					0	0	0	0	T	202915728	T	T	202915728	3	4	80	1	0	0	0	0	1	0	0	0	318	855	30	2	878	2	ADIPOR1	1	202915728	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	46578189	202915728	46334893	8	15950											
OBSCN	84033	broad.mit.edu	37	chr1	228557643	228557643	+	Missense_Mutation	SNP	C	G	G																															gaccctccctctgtcttcagCctgacctgctcatccccatt																										TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:228557643C>G	uc009xez.1	+	91	20012	c.19968C>G	c.(19966-19968)AGC>AGG	p.S6656R	OBSCN_uc001hsr.1_Missense_Mutation_p.S1285R	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6656	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTGTCTTCAGCCTGACCTGCT	0.622													45	36					0	0	0	0	G	228557643	G	G	228557643	3	3	80	1	0	0	0	0	1	0	0	0	10866	753	26	4	21536	4	OBSCN	1	228557643	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	25641915	228557643	20692978	9	15951	32	2									
OBSCN	84033	broad.mit.edu	37	chr1	228557645	228557645	+	Missense_Mutation	SNP	T	G	G																															ccctccctctgtcttcagccTgacctgctcatccccatttg																										TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:228557645T>G	uc009xez.1	+	91	20014	c.19970T>G	c.(19969-19971)CTG>CGG	p.L6657R	OBSCN_uc001hsr.1_Missense_Mutation_p.L1286R	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6657	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GTCTTCAGCCTGACCTGCTCA	0.622													46	37					0	0	0	0	G	228557645	G	G	228557645	3	3	80	1	0	0	0	0	1	0	0	0	10866	1580	55	5	21538	5	OBSCN	1	228557645	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08	2	228557645	20692976	10	15952	32	2									
NT5C1B	93034	broad.mit.edu	37	chr2	18767631	18767631	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtaccctcgagagtctgtCttccgcagtgatgattcttg	7	13	11	10	2	3	3	0	2	3	1	5	4	4	3	2	1	1	2	2	1	1	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:18767631C>T	uc002rcz.2	-	4	431	c.327G>A	c.(325-327)AAG>AAA	p.K109K	NT5C1B_uc002rcy.2_Silent_p.K109K|NT5C1B_uc010exr.2_Silent_p.K49K|NT5C1B_uc010yju.1_Silent_p.K49K|NT5C1B_uc002rda.2_Silent_p.K49K|NT5C1B_uc010yjv.1_Silent_p.K126K|NT5C1B_uc010yjw.1_Silent_p.K92K|NT5C1B_uc010exs.2_Silent_p.K109K|NT5C1B_uc002rdb.1_5'Flank	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	109	Ser-rich.				purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GAGAGTCTGTCTTCCGCAGTG	0.498													6	46					0	0	0	0	T	18767631	T	T	18767631	2	4	80	1	0	0	0	0	0	0	0	1	10740	912	32	2		2	NT5C1B	2	18767631	Silent	SNP	C	TCGA-CN-6023-01A-11D-1683-08		18767631	224431742	11	15953											
HADHA	3030	broad.mit.edu	37	chr2	26438045	26438045	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggttttagtcctggtcCtataaaaatgaatgcaacac	13	12	9	7	0	0	1	0	1	0	0	2	2	2	2	2	3	2	2	2	3	7	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:26438045C>T	uc002rgy.2	-	8	807	c.677_splice	c.e8-1	p.G226_splice	HADHA_uc010yks.1_Splice_Site_p.G139_splice|HADHA_uc010ykt.1_Splice_Site_p.G139_splice	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha						fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	AGTCCTGGTCCTATAAAAATG	0.438													23	105					0	0	0	0	T	26438045	T	T	26438045	5	4	80	1	0	0	0	0	0	0	1	0	6982	695	24	4	1667	4	HADHA	2	26438045	Splice_Site	SNP	C	TCGA-CN-6023-01A-11D-1683-08	7670414	26438045	216761328	12	15954											
ALK	238	broad.mit.edu	37	chr2	29456500	29456500	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgcacgcttctgttcacAcggatttcttcttctatcac	7	16	5	13	2	7	0	3	0	4	0	7	1	7	1	0	1	1	3	0	1	1	6			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:29456500A>T	uc002rmy.2	-	14	3325	c.2418T>A	c.(2416-2418)CGT>CGA	p.R806R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	806	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TTCTGTTCACACGGATTTCTT	0.488			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				26	70					0	0	0	0	T	29456500	T	T	29456500	2	4	80	1	0	0	0	0	0	0	0	1	525	146	6	5		5	ALK	2	29456500	Silent	SNP	A	TCGA-CN-6023-01A-11D-1683-08	3018455	29456500	213742873	13	15955											
ALMS1	7840	broad.mit.edu	37	chr2	73717132	73717132	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atggacccttggctgtcagaAttagtagaacctgcttttgt	9	14	10	8	0	1	2	1	0	0	2	1	3	1	3	2	2	2	3	2	2	4	5			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:73717132A>G	uc002sje.1	+	12	8160	c.8049A>G	c.(8047-8049)GAA>GAG	p.E2683E	ALMS1_uc002sjf.1_Silent_p.E2639E|ALMS1_uc002sjg.2_Silent_p.E2069E|ALMS1_uc002sjh.1_Silent_p.E2069E	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2681					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GGCTGTCAGAATTAGTAGAAC	0.403													24	143					0	0	0	0	G	73717132	G	G	73717132	2	3	80	1	0	0	0	0	0	0	0	1	535	98	4	5		5	ALMS1	2	73717132	Silent	SNP	A	TCGA-CN-6023-01A-11D-1683-08	44260632	73717132	169482241	14	15956											
TSGA10	80705	broad.mit.edu	37	chr2	99726007	99726007	+	Translation_Start_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttattttgtgctttttcagTatctaaaattatcttgccaa	10	21	4	6	0	3	0	1	0	2	0	3	0	3	0	1	0	2	2	1	0	6	10			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:99726007T>C	uc002szg.3	-	4	524	c.-104A>G	c.(-106--102)ATACT>ATGCT		TSGA10_uc002szh.3_Intron|TSGA10_uc002szi.3_Intron|TSGA10_uc010fin.1_Translation_Start_Site|TSGA10_uc010yvn.1_Intron	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10						spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						GCTTTTTCAGTATCTAAAATT	0.318													6	13					0	0	0	0	C	99726007	C	C	99726007	1	2	80	1	0	0	0	0	0	0	0	0	16684	1653	57	5		5	TSGA10	2	99726007	Translation_Start_Site	SNP	T	TCGA-CN-6023-01A-11D-1683-08	26008875	99726007	143473366	15	15957											
SLC9A2	6549	broad.mit.edu	37	chr2	103321047	103321047	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgacagccgacacaagtgaGagacaagccaaggagattct	15	5	11	10	1	1	4	0	2	1	2	1	7	1	4	2	1	2	0	2	1	3	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:103321047G>C	uc002tca.2	+	10	2032	c.1890G>C	c.(1888-1890)GAG>GAC	p.E630D		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	630	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						ACACAAGTGAGAGACAAGCCA	0.428													5	28					0	0	0	0	C	103321047	C	C	103321047	3	2	80	1	0	0	0	0	1	0	0	0	14776	933	33	2	1928	2	SLC9A2	2	103321047	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	3595040	103321047	139878326	16	15958											
GCC2	9648	broad.mit.edu	37	chr2	109088215	109088215	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtgatgaaaaagtattagaGttagaaaaagagattaagtg	19	10	11	1	1	0	5	0	2	0	3	0	6	0	5	0	0	0	2	0	0	8	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:109088215G>C	uc002tec.2	+	6	2584	c.2430G>C	c.(2428-2430)GAG>GAC	p.E810D	GCC2_uc002ted.2_Missense_Mutation_p.E709D	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	810	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAGTATTAGAGTTAGAAAAAG	0.363													18	55					0	0	0	0	C	109088215	C	C	109088215	3	2	80	1	0	0	0	0	1	0	0	0	6321	1020	36	4	2452	4	GCC2	2	109088215	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	5767168	109088215	134111158	17	15959											
TTN	7273	broad.mit.edu	37	chr2	179459274	179459275	+	Frame_Shift_Ins	INS	-	T	T																															ttctaggacatagttaataaINStttctgacccaccatcatac																										TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:179459274_179459275insT	uc010zfg.1	-	245	50466_50467	c.50242_50243insA	c.(50242-50244)ATTfs	p.I16748fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Ins_p.I10443fs|TTN_uc010zfi.1_Frame_Shift_Ins_p.I10376fs|TTN_uc010zfj.1_Frame_Shift_Ins_p.I10251fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17675							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAGTTAATAATTTCTGACCCA	0.391													---	---	---								T	179459275	T	T	179459274	7	5	80	1	0	1	1	0	0	0	0	0	16803	101	4	0	50300	0	TTN	2	179459274	Frame_Shift_Ins	INS	-	TCGA-CN-6023-01A-11D-1683-08	70371059	179459274	63740099	18	15960											
LMCD1	29995	broad.mit.edu	37	chr3	8579047	8579047	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaccggatgatcatgaccaAccctattgctactgggaaag	13	8	10	10	1	1	2	1	2	0	0	1	5	1	4	3	2	4	1	3	2	5	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:8579047A>G	uc003bqq.2	+	3	422	c.308A>G	c.(307-309)AAC>AGC	p.N103S	LMCD1_uc011atd.1_Missense_Mutation_p.N30S|LMCD1_uc011ate.1_Intron|LMCD1_uc011atf.1_Missense_Mutation_p.N30S	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	103	PET.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		ATCATGACCAACCCTATTGCT	0.552													10	138					0	0	0	0	G	8579047	G	G	8579047	3	3	80	1	0	0	0	0	1	0	0	0	8886	43	2	5	318	5	LMCD1	3	8579047	Missense_Mutation	SNP	A	TCGA-CN-6023-01A-11D-1683-08		8579047	189443383	19	15961											
ZNF445	353274	broad.mit.edu	37	chr3	44488834	44488834	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aactctctgatggatgaggaGgaatgagtgattgcggaagg	12	9	16	4	1	1	4	0	4	1	0	2	8	1	8	0	5	2	0	0	5	3	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:44488834G>C	uc003cnf.2	-	8	2677	c.2329C>G	c.(2329-2331)CTC>GTC	p.L777V	ZNF445_uc011azv.1_Missense_Mutation_p.L765V|ZNF445_uc011azw.1_Missense_Mutation_p.L777V	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	777	C2H2-type 8.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		TGGATGAGGAGGAATGAGTGA	0.512													21	20					0	0	0	0	C	44488834	C	C	44488834	3	2	80	1	0	0	0	0	1	0	0	0	17985	1000	35	4	770	4	ZNF445	3	44488834	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	35909787	44488834	153533596	20	15962											
CCDC36	339834	broad.mit.edu	37	chr3	49293597	49293597	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttatagaaatgaagtccAacctgaagcaccttgaagtt	15	11	8	7	0	0	4	0	3	0	1	1	4	1	4	3	0	2	3	3	0	7	5			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:49293597A>G	uc003cwk.2	+	10	1054	c.667A>G	c.(667-669)AAC>GAC	p.N223D	CCDC36_uc011bck.1_Missense_Mutation_p.N223D	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	223	Potential.									ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		AATGAAGTCCAACCTGAAGCA	0.473													34	58					0	0	0	0	G	49293597	G	G	49293597	3	3	80	1	0	0	0	0	1	0	0	0	2821	130	5	5	693	5	CCDC36	3	49293597	Missense_Mutation	SNP	A	TCGA-CN-6023-01A-11D-1683-08	4804763	49293597	148728833	21	15963											
BSN	8927	broad.mit.edu	37	chr3	49699628	49699628	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcaccttctgcatacagTggggagaagctgtccagcca	9	7	13	12	1	1	1	0	0	1	1	2	2	2	1	3	3	4	3	3	3	2	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:49699628T>G	uc003cxe.3	+	6	10464	c.10350T>G	c.(10348-10350)AGT>AGG	p.S3450R		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3450					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTGCATACAGTGGGGAGAAGC	0.607													5	36					0	0	0	0	G	49699628	G	G	49699628	3	3	80	1	0	0	0	0	1	0	0	0	1535	1693	59	5	10372	5	BSN	3	49699628	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08	406031	49699628	148322802	22	15964											
A4GNT	51146	broad.mit.edu	37	chr3	137843343	137843343	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccactctcgataggagatGgggtaaaatctttgggggtg	9	11	14	7	1	2	1	0	0	2	1	4	3	3	1	1	5	0	1	1	5	3	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:137843343G>T	uc003ers.2	-	3	988	c.786C>A	c.(784-786)CCC>CCA	p.P262P		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	262	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						GATAGGAGATGGGGTAAAATC	0.483													11	79					0.000151284	0.000160484	1	0	T	137843343	T	T	137843343	2	4	80	1	0	0	0	0	0	0	0	1	7	1335	47	4		4	A4GNT	3	137843343	Silent	SNP	G	TCGA-CN-6023-01A-11D-1683-08	88143715	137843343	60179087	23	15965											
MRPS22	56945	broad.mit.edu	37	chr3	139067116	139067116	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataagattttggaaggaacaGaaacaaccaaatatgtgttt	18	11	8	4	0	0	2	0	0	0	2	0	4	0	4	1	2	3	1	1	2	7	5			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:139067116G>A	uc003etb.2	+	3	462	c.454G>A	c.(454-456)GAA>AAA	p.E152K	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.E151K|MRPS22_uc003ete.2_Missense_Mutation_p.E111K	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	152						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						GGAAGGAACAGAAACAACCAA	0.363													38	73					0	0	0	0	A	139067116	A	A	139067116	3	1	80	1	0	0	0	0	1	0	0	0	9886	943	33	2	464	2	MRPS22	3	139067116	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	1223773	139067116	58955314	24	15966											
ATR	545	broad.mit.edu	37	chr3	142168296	142168296	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatatggagtccaaccaagaTacatctggcatagtaagttt	14	12	8	7	0	1	1	0	0	1	1	2	2	2	2	2	2	2	3	2	2	7	6			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:142168296T>C	uc003eux.3	-	47	8032	c.7910A>G	c.(7909-7911)TAT>TGT	p.Y2637C	XRN1_uc003eus.2_5'Flank|XRN1_uc003eut.2_5'Flank|XRN1_uc003euu.2_5'Flank|XRN1_uc003euw.2_5'Flank|XRN1_uc011bnh.1_5'Flank|ATR_uc003euy.1_3'UTR	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2637	FATC.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CCAACCAAGATACATCTGGCA	0.338								Other_conserved_DNA_damage_response_genes					15	91					0	0	0	0	C	142168296	C	C	142168296	3	2	80	1	0	0	0	0	1	0	0	0	1206	1406	49	5	28	5	ATR	3	142168296	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08	3101180	142168296	55854134	25	15967											
SI	6476	broad.mit.edu	37	chr3	164786949	164786949	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaataagagagtcattccacGgcctccagcagcagcctctc	11	7	9	14	1	2	1	1	0	1	1	5	3	4	1	4	1	3	2	4	1	2	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:164786949G>A	uc003fei.2	-	4	352	c.290C>T	c.(289-291)CCG>CTG	p.P97L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	97	Lumenal.|P-type 1.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTCATTCCACGGCCTCCAGCA	0.373										HNSCC(35;0.089)			6	48					0	0	0	0	A	164786949	A	A	164786949	3	1	80	1	0	0	0	0	1	0	0	0	14362	1116	39	1	5373	1	SI	3	164786949	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	22618653	164786949	33235481	26	15968											
MASP1	5648	broad.mit.edu	37	chr3	187003846	187003846	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataatagagaagcagccaccTgaaagacatgaatgtaggtc	17	7	10	7	0	0	4	0	2	0	2	1	5	0	4	2	1	2	2	2	1	6	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:187003846T>A	uc003frh.1	-	2	338	c.6_splice	c.e2-1	p.R2_splice	MASP1_uc003fri.2_Splice_Site_p.R2_splice|MASP1_uc003frj.2_Intron|MASP1_uc003frk.1_Splice_Site_p.R2_splice|MASP1_uc011bse.1_Splice_Site	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform						complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		AGCAGCCACCTGAAAGACATG	0.478													13	39					0	0	0	0	A	187003846	A	A	187003846	5	1	80	1	0	0	0	0	0	0	1	0	9375	1594	55	5	3100	5	MASP1	3	187003846	Splice_Site	SNP	T	TCGA-CN-6023-01A-11D-1683-08	22216897	187003846	11018584	27	15969											
ATP13A4	84239	broad.mit.edu	37	chr3	193175175	193175175	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aagcagggcttacctggctgGctgttctgcagggcttaact	7	11	13	10	0	1	0	0	0	1	0	1	0	1	0	1	4	4	7	1	4	3	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:193175175G>C	uc003ftd.2	-	15	1862	c.1754C>G	c.(1753-1755)GCC>GGC	p.A585G	ATP13A4_uc003fte.1_Missense_Mutation_p.A585G|ATP13A4_uc011bsr.1_Missense_Mutation_p.A56G|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	585	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TACCTGGCTGGCTGTTCTGCA	0.483													19	281					0	0	0	0	C	193175175	C	C	193175175	3	2	80	1	0	0	0	0	1	0	0	0	1128	1203	42	4	1900	4	ATP13A4	3	193175175	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	6171329	193175175	4847255	28	15970											
LRCH3	84859	broad.mit.edu	37	chr3	197585726	197585726	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctgtcagggttgaatcaaGtgggctgtgctgctaccctg	6	11	14	10	1	2	1	2	1	0	0	2	1	2	1	1	2	3	5	1	2	3	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:197585726G>C	uc011bul.1	+	15	1671	c.1666G>C	c.(1666-1668)GTG>CTG	p.V556L	LRCH3_uc003fyj.1_Missense_Mutation_p.V556L|LRCH3_uc011bum.1_Intron|LRCH3_uc011bun.1_Missense_Mutation_p.V402L|LRCH3_uc003fyk.2_Missense_Mutation_p.V151L	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	556						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		GTTGAATCAAGTGGGCTGTGC	0.453													40	134					0	0	0	0	C	197585726	C	C	197585726	3	2	80	1	0	0	0	0	1	0	0	0	8984	1029	36	4	1724	4	LRCH3	3	197585726	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	4410551	197585726	436704	29	15971											
PPARGC1A	10891	broad.mit.edu	37	chr4	23830203	23830203	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttgacaaatactcttcgCtttattgctccatgaattct	9	17	5	10	1	2	2	0	2	2	0	4	2	3	2	1	0	2	3	1	0	4	7			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr4:23830203C>T	uc003gqs.2	-	5	697	c.577G>A	c.(577-579)GCG>ACG	p.A193T	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	193					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				ATACTCTTCGCTTTATTGCTC	0.413													3	87					0	0	0	0	T	23830203	T	T	23830203	3	4	80	1	0	0	0	0	1	0	0	0	12355	797	28	4	1855	4	PPARGC1A	4	23830203	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08		23830203	167324073	30	15972											
COX18	285521	broad.mit.edu	37	chr4	73930982	73930982	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attaccttctgaatgtgctgCccccgtgcttaaattccgga	8	13	8	12	2	1	1	0	1	1	0	2	2	2	2	4	1	4	2	4	1	4	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr4:73930982C>A	uc003hgm.1	-	3	689	c.583G>T	c.(583-585)GCA>TCA	p.A195S	COX18_uc003hgn.1_Missense_Mutation_p.A44S|COX18_uc011cbc.1_Missense_Mutation_p.A195S|COX18_uc010iih.1_Missense_Mutation_p.A195S	NM_173827	NP_776188	Q8N8Q8	COX18_HUMAN	mitochondrial COX18 precursor	195					protein insertion into mitochondrial membrane|respiratory chain complex IV assembly	integral to mitochondrial inner membrane	protein transporter activity				0	Breast(15;0.00096)		Epithelial(6;1.26e-06)|OV - Ovarian serous cystadenocarcinoma(6;9.45e-06)|all cancers(17;2.05e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GAATGTGCTGCCCCCGTGCTT	0.378													17	30					2.35188e-11	2.71504e-11	1	0	A	73930982	A	A	73930982	3	1	80	1	0	0	0	0	1	0	0	0	3782	739	26	4	434	4	COX18	4	73930982	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	50100779	73930982	117223294	31	15973											
SEC24B	10427	broad.mit.edu	37	chr4	110384711	110384711	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atacagtactctaacgtggtCatctccaggccttccatcga	10	11	7	13	2	3	0	1	0	2	0	6	1	4	0	3	2	3	1	3	2	3	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr4:110384711C>T	uc003hzk.2	+	2	843	c.788C>T	c.(787-789)TCA>TTA	p.S263L	SEC24B_uc003hzl.2_Missense_Mutation_p.S263L|SEC24B_uc011cfp.1_Missense_Mutation_p.S294L|SEC24B_uc011cfq.1_Missense_Mutation_p.S263L|SEC24B_uc011cfr.1_Missense_Mutation_p.S263L	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	263					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CTAACGTGGTCATCTCCAGGC	0.488													20	40					0	0	0	0	T	110384711	T	T	110384711	3	4	80	1	0	0	0	0	1	0	0	0	14060	838	29	2	794	2	SEC24B	4	110384711	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	36453729	110384711	80769565	32	15974											
RAI14	26064	broad.mit.edu	37	chr5	34823598	34823598	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaaagtgaaagaaataaaGagaaagtgagagagttagag	23	5	13	0	0	0	7	0	2	0	5	0	9	0	7	0	0	0	1	0	0	8	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr5:34823598G>C	uc003jir.2	+	15	1847	c.1651G>C	c.(1651-1653)GAG>CAG	p.E551Q	RAI14_uc010iur.2_Missense_Mutation_p.E522Q|RAI14_uc011coj.1_Missense_Mutation_p.E551Q|RAI14_uc003jis.2_Missense_Mutation_p.E554Q|RAI14_uc003jit.2_Missense_Mutation_p.E551Q|RAI14_uc011cok.1_Missense_Mutation_p.E543Q	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	551	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					aagaaataaagagaaagtgag	0.274													3	44					0	0	0	0	C	34823598	C	C	34823598	3	2	80	1	0	0	0	0	1	0	0	0	13073	943	33	2	1770	2	RAI14	5	34823598	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08		34823598	146091662	33	15975											
RASA1	5921	broad.mit.edu	37	chr5	86670020	86670020	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattgaagaagcccataaacTcccagtaaaacattttacta	17	11	4	9	0	0	2	0	1	0	1	1	2	1	2	2	0	4	1	2	0	9	7			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr5:86670020T>A	uc003kiw.2	+	14	1935	c.1817T>A	c.(1816-1818)CTC>CAC	p.L606H	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.L429H|RASA1_uc011ctv.1_Missense_Mutation_p.L439H|RASA1_uc011ctw.1_Missense_Mutation_p.L440H|RASA1_uc010jaw.2_Missense_Mutation_p.L428H	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	606	C2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		GCCCATAAACTCCCAGTAAAA	0.333													7	11					0	0	0	0	A	86670020	A	A	86670020	3	1	80	1	0	0	0	0	1	0	0	0	13125	1551	54	5	1883	5	RASA1	5	86670020	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08	51846422	86670020	94245240	34	15976											
RAD50	10111	broad.mit.edu	37	chr5	131915747	131915747	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcctatgagaatgaacttGatccattgaaggtaacttga	15	12	8	6	0	0	5	0	5	0	1	2	6	2	5	2	1	2	1	2	1	6	5			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr5:131915747G>T	uc003kxi.2	+	5	1132	c.745G>T	c.(745-747)GAT>TAT	p.D249Y	RAD50_uc003kxg.1_Missense_Mutation_p.D150Y|RAD50_uc003kxh.2_Missense_Mutation_p.D110Y	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	249	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAATGAACTTGATCCATTGAA	0.209								Homologous_recombination					8	45					5.18039e-06	5.57069e-06	1	0	T	131915747	T	T	131915747	3	4	80	1	0	0	0	0	1	0	0	0	13049	1290	45	2	763	2	RAD50	5	131915747	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	45245727	131915747	48999513	35	15977											
SIL1	64374	broad.mit.edu	37	chr5	138362615	138362615	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtctcaatgacaacattcaGctcatcaaagtctttcttca	13	13	4	11	0	7	1	5	1	3	0	8	1	7	1	0	0	2	1	0	0	3	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr5:138362615G>C	uc003ldm.2	-	5	537	c.520C>G	c.(520-522)CTG>GTG	p.L174V	SIL1_uc003ldn.2_Missense_Mutation_p.L173V|SIL1_uc003ldo.2_Missense_Mutation_p.L174V|SIL1_uc003ldp.2_Missense_Mutation_p.L174V|SIL1_uc003ldq.1_Intron	NM_022464	NP_071909	Q9H173	SIL1_HUMAN	SIL1 protein precursor	174	Interaction with HSPA5 and localization to the endoplasmic reticulum (By similarity).				intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACAACATTCAGCTCATCAAAG	0.468									Marinesco-Sj_gren_syndrome				9	40					0	0	0	0	C	138362615	C	C	138362615	3	2	80	1	0	0	0	0	1	0	0	0	14386	962	34	4	885	4	SIL1	5	138362615	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	6446868	138362615	42552645	36	15978											
HIVEP1	3096	broad.mit.edu	37	chr6	12125603	12125603	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagtgaattgcaggaatttGaaaacatcaagtcatccaca	17	10	7	7	0	2	2	2	2	0	0	3	3	3	3	1	1	2	1	1	1	6	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:12125603G>A	uc003nac.2	+	4	5754	c.5575G>A	c.(5575-5577)GAA>AAA	p.E1859K	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1859					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GCAGGAATTTGAAAACATCAA	0.338													37	44					0	0	0	0	A	12125603	A	A	12125603	3	1	80	1	0	0	0	0	1	0	0	0	7225	1291	45	2	5585	2	HIVEP1	6	12125603	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08		12125603	158989464	37	15979											
HIST1H4C	8364	broad.mit.edu	37	chr6	26104071	26104072	+	5'Flank	INS	-	A	A																															ccacttggtgaccaaatttgINSaaaaaaaaaaaaaaccgcgc																								rs66884675		TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:26104071_26104072insA	uc003ngi.2	+							NM_003542	NP_003533	P62805	H4_HUMAN	histone cluster 1, H4c						CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						GACCAAATTTGAAAAAAAAAAA	0.416													---	---	---								A	26104072	A	A	26104071	6	5	80	0	1	1	1	0	0	0	0	0	7206	1305	45	0		0	HIST1H4C	6	26104071	5'Flank	INS	-	TCGA-CN-6023-01A-11D-1683-08	13978468	26104071	145010996	38	15980											
ABCF1	23	broad.mit.edu	37	chr6	30547713	30547713	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgtgtctcctccaggccgtAtctgaggaacagcagcctgc	7	9	12	13	1	2	1	0	1	2	0	4	2	3	2	4	2	4	2	4	2	2	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:30547713A>G	uc003nql.2	+	7	590	c.495A>G	c.(493-495)GTA>GTG	p.V165V	ABCF1_uc003nqk.2_Silent_p.V166V|ABCF1_uc003nqm.2_Silent_p.V165V|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	165	Glu-rich.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						TCCAGGCCGTATCTGAGGAAC	0.433													7	8					0	0	0	0	G	30547713	G	G	30547713	2	3	80	1	0	0	0	0	0	0	0	1	65	436	16	5		5	ABCF1	6	30547713	Silent	SNP	A	TCGA-CN-6023-01A-11D-1683-08	4443642	30547713	140567354	39	15981											
COL21A1	81578	broad.mit.edu	37	chr6	55922598	55922598	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgccagggagacctgggtCtcctggaggaccttctttgc	5	12	13	11	0	2	1	0	0	2	1	3	4	2	3	4	4	2	0	4	4	0	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:55922598C>G	uc003pcs.2	-	30	2963	c.2731G>C	c.(2731-2733)GAC>CAC	p.D911H	COL21A1_uc010jzz.2_Missense_Mutation_p.D296H|COL21A1_uc011dxg.1_Missense_Mutation_p.D284H|COL21A1_uc011dxh.1_Missense_Mutation_p.D262H|COL21A1_uc003pcr.2_Missense_Mutation_p.D268H	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	911					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			AGACCTGGGTCTCCTGGAGGA	0.498													8	11					0	0	0	0	G	55922598	G	G	55922598	3	3	80	1	0	0	0	0	1	0	0	0	3695	913	32	2	146	2	COL21A1	6	55922598	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	25374885	55922598	115192469	40	15982											
BCLAF1	9774	broad.mit.edu	37	chr6	136582553	136582553	+	Frame_Shift_Del	DEL	A	-	-																															aagcgccctctgccacgttgAaaagtaccacgacctcttcc																										TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:136582553delA	uc003qgx.1	-	12	2860	c.2607delT	c.(2605-2607)TTTfs	p.F869fs	BCLAF1_uc011edb.1_Frame_Shift_Del_p.F148fs|BCLAF1_uc003qgw.1_Frame_Shift_Del_p.F696fs|BCLAF1_uc003qgy.1_Frame_Shift_Del_p.F818fs|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Frame_Shift_Del_p.F867fs	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	869					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGCCACGTTGAAAAGTACCAC	0.413													---	---	---								-	136582553	-	-	136582553	7	5	80	1	0	1	0	1	0	0	0	0	1385	243	9	0	163	0	BCLAF1	6	136582553	Frame_Shift_Del	DEL	A	TCGA-CN-6023-01A-11D-1683-08	80659955	136582553	34532514	41	15983											
ECT2L	345930	broad.mit.edu	37	chr6	139223693	139223693	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataaatggatttgtgctacaGaaatagaggatgataagttc	16	12	10	3	0	0	3	0	1	0	2	1	5	0	5	0	2	2	2	0	2	6	6			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:139223693G>A	uc003qif.1	+	20	2747	c.2644G>A	c.(2644-2646)GAA>AAA	p.E882K	ECT2L_uc011edq.1_Missense_Mutation_p.E736K	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	882					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TTGTGCTACAGAAATAGAGGA	0.368													12	37					0	0	0	0	A	139223693	A	A	139223693	3	1	80	1	0	0	0	0	1	0	0	0	4924	943	33	2	2722	2	ECT2L	6	139223693	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	2641140	139223693	31891374	42	15984											
RGS17	26575	broad.mit.edu	37	chr6	153347672	153347672	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctttcttcattcctcacAgtgaggctgtaatgtaacag	9	14	7	11	0	4	1	2	1	2	0	5	1	5	1	2	1	1	3	2	1	2	5			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:153347672A>T	uc003qpm.2	-	3	282	c.126T>A	c.(124-126)ACT>ACA	p.T42T		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	42					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		CATTCCTCACAGTGAGGCTGT	0.403									Lung_Cancer_Familial_Clustering_of				26	59					0	0	0	0	T	153347672	T	T	153347672	2	4	80	1	0	0	0	0	0	0	0	1	13364	175	7	5		5	RGS17	6	153347672	Silent	SNP	A	TCGA-CN-6023-01A-11D-1683-08	14123979	153347672	17767395	43	15985											
ITGB8	3696	broad.mit.edu	37	chr7	20441678	20441678	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgtcacaaaattaagcttgGaaaagtgtatggaaaatact	18	11	8	4	0	1	0	1	0	0	0	1	2	1	2	0	2	2	2	0	2	9	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:20441678G>T	uc003suu.2	+	10	2321	c.1616G>T	c.(1615-1617)GGA>GTA	p.G539V	ITGB8_uc011jyh.1_Missense_Mutation_p.G404V	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	539	Cysteine-rich tandem repeats.|II.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						ATTAAGCTTGGAAAAGTGTAT	0.388													28	101					5.77227e-19	6.76303e-19	1	0	T	20441678	T	T	20441678	3	4	80	1	0	0	0	0	1	0	0	0	7940	1174	41	2	1654	2	ITGB8	7	20441678	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08		20441678	138696985	44	15986											
PURB	5814	broad.mit.edu	37	chr7	44924293	44924294	+	Missense_Mutation	DNP	GC	AA	AA																															gatggaggtgccctccgggaGctctccatacaggccgcccc																										TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:44924293_44924294GC>AA	uc003tme.2	-	1	667_668	c.654_655GC>TT	c.(652-657)GAGCTC>GATTTC	p.218_219EL>DF		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	218_219	Gly-rich.|By similarity.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						CCCTCCGGGAGCTCTCCATACA	0.48													15	50					0	0	0	0	AA	44924294	AA	AA	44924293	3	1	80	1	0	0	0	0	1	0	0	0	12893	971	34	4	287	4	PURB	7	44924293	Missense_Mutation	DNP	GC	TCGA-CN-6023-01A-11D-1683-08	24482615	44924293	114214370	45	15987											
FZD1	8321	broad.mit.edu	37	chr7	90895177	90895177	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggattggcatttggtcaGtgctgtgctgcgcctccacg	4	12	13	12	2	1	0	1	0	0	0	2	1	2	1	3	3	3	3	3	3	0	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:90895177G>C	uc003ula.2	+	1	1395	c.982G>C	c.(982-984)GTG>CTG	p.V328L		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	328	Helical; Name=1; (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CATTTGGTCAGTGCTGTGCTG	0.627													15	87					0	0	0	0	C	90895177	C	C	90895177	3	2	80	1	0	0	0	0	1	0	0	0	6162	1029	36	4	984	4	FZD1	7	90895177	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	45970884	90895177	68243486	46	15988											
TRRAP	8295	broad.mit.edu	37	chr7	98535316	98535316	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcgatcaaatccacacacAtatgcgacctttgctgatga	13	10	7	11	2	1	2	1	2	0	0	3	4	2	2	2	0	2	1	2	0	2	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:98535316A>T	uc003upp.2	+	30	4486	c.4277A>T	c.(4276-4278)CAT>CTT	p.H1426L	TRRAP_uc011kis.1_Missense_Mutation_p.H1426L|TRRAP_uc003upr.2_Missense_Mutation_p.H1118L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1426					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ATCCACACACATATGCGACCT	0.413													11	69					0	0	0	0	T	98535316	T	T	98535316	3	4	80	1	0	0	0	0	1	0	0	0	16668	217	8	5	4391	5	TRRAP	7	98535316	Missense_Mutation	SNP	A	TCGA-CN-6023-01A-11D-1683-08	7640139	98535316	60603347	47	15989											
PTPRZ1	5803	broad.mit.edu	37	chr7	121636535	121636535	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtcgtttatgataccatgaTtgagaagtttgcagttttgt	10	17	10	4	1	0	3	0	3	0	1	1	4	0	3	1	0	2	4	1	0	3	7			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:121636535T>C	uc003vjy.2	+	9	1423	c.1028T>C	c.(1027-1029)ATT>ACT	p.I343T	PTPRZ1_uc003vjz.2_Missense_Mutation_p.I343T	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	343	Extracellular (Potential).|Fibronectin type-III.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						GATACCATGATTGAGAAGTTT	0.408													4	98					0	0	0	0	C	121636535	C	C	121636535	3	2	80	1	0	0	0	0	1	0	0	0	12879	1493	52	5	1062	5	PTPRZ1	7	121636535	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08	23101219	121636535	37502128	48	15990											
RNF133	168433	broad.mit.edu	37	chr7	122338545	122338545	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcttcaaatgcctgatgaAacatggggaacacctggttg	12	10	10	9	0	2	2	1	2	1	0	2	3	2	3	2	3	3	1	2	3	3	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:122338545A>C	uc003vkj.1	-	1	664	c.428T>G	c.(427-429)TTT>TGT	p.F143C	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	143	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						TGCCTGATGAAACATGGGGAA	0.423													32	58					0	0	0	0	C	122338545	C	C	122338545	3	2	80	1	0	0	0	0	1	0	0	0	13504	14	1	5	706	5	RNF133	7	122338545	Missense_Mutation	SNP	A	TCGA-CN-6023-01A-11D-1683-08	702010	122338545	36800118	49	15991											
KLHDC10	23008	broad.mit.edu	37	chr7	129761910	129761910	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaggctatggccatcatcaAtggctccctttatgtctttg	7	14	8	12	0	3	0	2	0	1	0	4	0	4	0	3	3	0	2	3	3	3	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:129761910A>G	uc003vpj.1	+	5	782	c.647A>G	c.(646-648)AAT>AGT	p.N216S	KLHDC10_uc003vpk.1_Missense_Mutation_p.N187S|KLHDC10_uc010lmb.1_Missense_Mutation_p.N113S	NM_014997	NP_055812	Q6PID8	KLD10_HUMAN	kelch domain containing 10	216	Kelch 2.										0						GCCATCATCAATGGCTCCCTT	0.418													7	32					0	0	0	0	G	129761910	G	G	129761910	3	3	80	1	0	0	0	0	1	0	0	0	8394	101	4	5	665	5	KLHDC10	7	129761910	Missense_Mutation	SNP	A	TCGA-CN-6023-01A-11D-1683-08	7423365	129761910	29376753	50	15992											
AKR1B1	231	broad.mit.edu	37	chr7	134135632	134135632	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggctcctttcaccaggcccTtctcatggtacgtgcaccac	7	10	8	16	1	2	0	2	0	1	0	4	0	3	0	4	3	2	3	4	3	1	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:134135632T>C	uc003vrp.1	-	3	331	c.257A>G	c.(256-258)AAG>AGG	p.K86R	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	86					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding	p.K86K(1)		ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	CACCAGGCCCTTCTCATGGTA	0.557													5	26					0	0	0	0	C	134135632	C	C	134135632	3	2	80	1	0	0	0	0	1	0	0	0	466	1609	56	5	725	5	AKR1B1	7	134135632	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08	4373722	134135632	25003031	51	15993											
MLL3	58508	broad.mit.edu	37	chr7	151874913	151874913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaactggcaagctctgtggtGaaaaatgctgaggaagtcca	13	8	13	7	0	1	2	0	2	1	0	2	4	2	3	1	3	3	3	1	3	5	0			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:151874913G>A	uc003wla.2	-	38	7844	c.7625C>T	c.(7624-7626)TCA>TTA	p.S2542L	MLL3_uc003wkz.2_Missense_Mutation_p.S1603L|MLL3_uc003wky.2_Missense_Mutation_p.S51L	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2542	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCTCTGTGGTGAAAAATGCTG	0.453			N		medulloblastoma								40	71					0	0	0	0	A	151874913	A	A	151874913	3	1	80	1	0	0	0	0	1	0	0	0	9675	1294	45	2	7198	2	MLL3	7	151874913	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	17739281	151874913	7263750	52	15994											
HTR5A	3361	broad.mit.edu	37	chr7	154863070	154863070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaatacacgctccgcacccGcaagtgcgtctccaacgtca	10	6	9	16	5	2	0	1	0	1	0	4	1	3	1	3	1	3	3	3	1	4	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:154863070G>A	uc003wlu.1	+	1	525	c.461G>A	c.(460-462)CGC>CAC	p.R154H	uc011kvt.1_5'UTR|uc003wlt.2_5'UTR	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	154	Cytoplasmic (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CTCCGCACCCGCAAGTGCGTC	0.617													9	25					0	0	0	0	A	154863070	A	A	154863070	3	1	80	1	0	0	0	0	1	0	0	0	7489	1087	38	1	463	1	HTR5A	7	154863070	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	2988157	154863070	4275593	53	15995											
CSMD1	64478	broad.mit.edu	37	chr8	3087643	3087643	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggcttgtccttggagctGatagccagggtcacactgga	7	12	13	9	0	1	1	1	1	0	0	2	3	2	3	2	4	2	2	2	4	1	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr8:3087643G>A	uc011kwk.1	-	27	4657	c.4267C>T	c.(4267-4269)CAG>TAG	p.Q1423*	CSMD1_uc011kwj.1_Nonsense_Mutation_p.Q815*|CSMD1_uc003wqe.2_Nonsense_Mutation_p.Q579*	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1423	Extracellular (Potential).|Sushi 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTTGGAGCTGATAGCCAGGG	0.517													10	16					0	0	0	0	A	3087643	A	A	3087643	4	1	80	1	0	0	0	0	0	1	0	0	3961	1299	45	2	6606	2	CSMD1	8	3087643	Nonsense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08		3087643	143276379	54	15996											
ZFPM2	23414	broad.mit.edu	37	chr8	106814630	106814630	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataatccttgtacctccactCaagaacccacagaagggcta	14	8	6	13	0	1	2	1	0	0	2	3	2	3	2	4	1	2	2	4	1	6	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr8:106814630C>T	uc003ymd.2	+	8	2343	c.2320C>T	c.(2320-2322)CAA>TAA	p.Q774*	ZFPM2_uc011lhs.1_Nonsense_Mutation_p.Q505*	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	774					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TACCTCCACTCAAGAACCCAC	0.463													4	27					0	0	0	0	T	106814630	T	T	106814630	4	4	80	1	0	0	0	0	0	1	0	0	17725	827	29	2	2350	2	ZFPM2	8	106814630	Nonsense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	103726987	106814630	39549392	55	15997											
LY6H	4062	broad.mit.edu	37	chr8	144239772	144239772	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccccattgcacaaatccttCtcgcagcagtccacgtcgac	9	8	7	17	3	1	0	0	0	1	0	5	1	3	0	4	0	2	3	4	0	1	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr8:144239772C>G	uc011lka.1	-	4	484	c.318G>C	c.(316-318)GAG>GAC	p.E106D	LY6H_uc011lkb.1_Missense_Mutation_p.E127D|LY6H_uc003yxt.2_Missense_Mutation_p.E144D|LY6H_uc011lkc.1_Missense_Mutation_p.E127D	NM_002347	NP_002338	O94772	LY6H_HUMAN	lymphocyte antigen 6 complex, locus H isoform a	106					nervous system development|organ morphogenesis	anchored to membrane|plasma membrane					0	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ACAAATCCTTCTCGCAGCAGT	0.612													5	49					0	0	0	0	G	144239772	G	G	144239772	3	3	80	1	0	0	0	0	1	0	0	0	9148	912	32	2	108	2	LY6H	8	144239772	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	37425142	144239772	2124250	56	15998											
KIAA1432	57589	broad.mit.edu	37	chr9	5773076	5773076	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaccgatgggcctctacaGactggtaagtgctgctttcc	7	11	12	11	1	1	1	0	0	1	1	2	3	2	2	3	3	3	3	3	3	2	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:5773076G>C	uc003zji.2	+	24	3835	c.3742G>C	c.(3742-3744)GAC>CAC	p.D1248H	KIAA1432_uc003zjl.3_Missense_Mutation_p.D1211H|ERMP1_uc011lme.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1327						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GGCCTCTACAGACTGGTAAGT	0.443													6	25					0	0	0	0	C	5773076	C	C	5773076	3	2	80	1	0	0	0	0	1	0	0	0	8272	942	33	2	3910	2	KIAA1432	9	5773076	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08		5773076	135440355	57	15999											
VCP	7415	broad.mit.edu	37	chr9	35059698	35059698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaggatctggttgatgactCggtcagcagccccaccacca	9	8	10	14	1	3	2	2	2	1	0	4	3	3	3	4	3	2	2	4	3	0	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:35059698C>T	uc003zvy.2	-	14	2185	c.1796G>A	c.(1795-1797)CGA>CAA	p.R599Q	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.R268Q|VCP_uc010mki.1_Missense_Mutation_p.R554Q	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	599					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTTGATGACTCGGTCAGCAGC	0.522													18	87					0	0	0	0	T	35059698	T	T	35059698	3	4	80	1	0	0	0	0	1	0	0	0	17208	884	31	1	640	1	VCP	9	35059698	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	29286622	35059698	106153733	58	16000											
VCP	7415	broad.mit.edu	37	chr9	35061650	35061650	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctaagcgtcctgtagcaTcaggaattccaatatctacc	11	12	6	12	1	3	0	1	0	2	0	6	1	5	1	3	1	3	2	3	1	6	5			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:35061650T>A	uc003zvy.2	-	10	1507	c.1118A>T	c.(1117-1119)GAT>GTT	p.D373V	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.D42V|VCP_uc010mki.1_Missense_Mutation_p.D328V	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	373					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TCCTGTAGCATCAGGAATTCC	0.478													11	187					0	0	0	0	A	35061650	A	A	35061650	3	1	80	1	0	0	0	0	1	0	0	0	17208	1435	50	5	1334	5	VCP	9	35061650	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08	1952	35061650	106151781	59	16001											
SHB	6461	broad.mit.edu	37	chr9	37948721	37948721	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcgcagcaggttctcggcGtctcctctgctgatggctcc	4	11	12	14	3	3	1	0	1	3	0	7	1	4	1	2	3	2	5	2	3	0	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:37948721G>A	uc004aax.2	-	5	1825	c.1257C>T	c.(1255-1257)GAC>GAT	p.D419D		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	419	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GGTTCTCGGCGTCTCCTCTGC	0.607													7	107					0	0	0	0	A	37948721	A	A	37948721	2	1	80	1	0	0	0	0	0	0	0	1	14333	1136	40	1		1	SHB	9	37948721	Silent	SNP	G	TCGA-CN-6023-01A-11D-1683-08	2887071	37948721	103264710	60	16002											
ZNF367	195828	broad.mit.edu	37	chr9	99150720	99150720	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttcaaagtgggggtgcgCtgctctctcatttcccaata	7	13	9	12	1	3	0	2	0	1	0	5	0	4	0	2	2	2	2	2	2	3	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:99150720C>T	uc004awf.2	-	5	1207	c.852G>A	c.(850-852)CAG>CAA	p.Q284Q		NM_153695	NP_710162	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	284					regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0167)				TGGGGGTGCGCTGCTCTCTCA	0.438													24	41					0	0	0	0	T	99150720	T	T	99150720	2	4	80	1	0	0	0	0	0	0	0	1	17938	796	28	4		4	ZNF367	9	99150720	Silent	SNP	C	TCGA-CN-6023-01A-11D-1683-08	61201999	99150720	42062711	61	16003											
COQ4	51117	broad.mit.edu	37	chr9	131088088	131088088	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cggatttcgacatccaccctCgacctgggcaagctccagag	9	7	10	15	3	0	1	0	0	0	1	4	4	2	2	4	2	1	2	4	2	1	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:131088088C>G	uc004bur.3	+	4	677	c.330C>G	c.(328-330)CTC>CTG	p.L110L	COQ4_uc011max.1_Silent_p.L110L|COQ4_uc004bus.2_Silent_p.L86L|COQ4_uc010mxy.2_Silent_p.L86L	NM_016035	NP_057119	Q9Y3A0	COQ4_HUMAN	coenzyme Q4 homolog precursor	110					ubiquinone biosynthetic process	mitochondrial inner membrane					0						CATCCACCCTCGACCTGGGCA	0.582													13	31					0	0	0	0	G	131088088	G	G	131088088	2	3	80	1	0	0	0	0	0	0	0	1	3762	871	31	3		3	COQ4	9	131088088	Silent	SNP	C	TCGA-CN-6023-01A-11D-1683-08	31937368	131088088	10125343	62	16004											
BMI1	648	broad.mit.edu	37	chr10	22618334	22618334	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagtactccagtgcagtctCctcatccacagtttcctcac	8	11	5	17	0	3	0	2	0	1	0	7	0	6	0	5	0	2	3	5	0	1	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:22618334C>A	uc001irh.2	+	10	1483	c.844C>A	c.(844-846)CCT>ACT	p.P282T	BMI1_uc009xkg.2_Missense_Mutation_p.P425T	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene	282	Pro/Ser-rich.				hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						AGTGCAGTCTCCTCATCCACA	0.507													25	79					2.44723e-14	2.84604e-14	1	0	A	22618334	A	A	22618334	3	1	80	1	0	0	0	0	1	0	0	0	1458	855	30	2	878	2	BMI1	10	22618334	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08		22618334	112916413	63	16005											
ANKRD26	22852	broad.mit.edu	37	chr10	27326225	27326225	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttctcgagaaagttgccTctgagcgtcatttcgctctt	6	15	9	11	3	4	2	1	1	3	1	6	3	4	2	1	0	2	3	1	0	1	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:27326225T>A	uc001ith.2	-	23	2756	c.2584A>T	c.(2584-2586)AGG>TGG	p.R862W	ANKRD26_uc001itg.2_Missense_Mutation_p.R549W|ANKRD26_uc009xku.1_Missense_Mutation_p.R863W	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	862	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						GAAAGTTGCCTCTGAGCGTCA	0.358													42	121					0	0	0	0	A	27326225	A	A	27326225	3	1	80	1	0	0	0	0	1	0	0	0	654	1550	54	5	2593	5	ANKRD26	10	27326225	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08	4707891	27326225	108208522	64	16006											
PTCHD3	374308	broad.mit.edu	37	chr10	27702586	27702586	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcggtgctcctcctggaggcGgagaagcggtaggagtcgtt	6	9	17	9	4	0	1	0	0	0	1	4	4	2	3	2	6	2	3	2	6	2	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:27702586G>A	uc001itu.2	-	1	712	c.594C>T	c.(592-594)TCC>TCT	p.S198S		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	198					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TCCTGGAGGCGGAGAAGCGGT	0.602													4	131					0	0	0	0	A	27702586	A	A	27702586	2	1	80	1	0	0	0	0	0	0	0	1	12796	1103	39	1		1	PTCHD3	10	27702586	Silent	SNP	G	TCGA-CN-6023-01A-11D-1683-08	376361	27702586	107832161	65	16007											
BMS1	9790	broad.mit.edu	37	chr10	43312844	43312846	+	In_Frame_Del	DEL	AAG	-	-																															ccaagaaaaagcatttggatAagaagagaaaattgaaggag																										TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:43312844_43312846delAAG	uc001jaj.2	+	15	2840_2842	c.2482_2484delAAG	c.(2482-2484)AAGdel	p.K829del		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	829					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GCATTTGGATAAGAAGAGAAAAT	0.34													---	---	---								-	43312846	-	-	43312844	7	5	80	1	0	1	0	1	0	0	0	0	1475	363	13	0	2536	0	BMS1	10	43312844	In_Frame_Del	DEL	AAG	TCGA-CN-6023-01A-11D-1683-08	15610258	43312844	92221903	66	16008											
MYOF	26509	broad.mit.edu	37	chr10	95069804	95069804	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtagaggagcacggccacGaagagcagcaggataagcag	15	2	16	8	2	0	2	0	0	0	2	0	6	0	4	1	3	4	5	1	3	3	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:95069804G>A	uc001kin.2	-	53	6243	c.6120C>T	c.(6118-6120)TTC>TTT	p.F2040F	MYOF_uc001kio.2_Silent_p.F2027F|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	2040	Helical; (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GCACGGCCACGAAGAGCAGCA	0.552													5	30					0	0	0	0	A	95069804	A	A	95069804	2	1	80	1	0	0	0	0	0	0	0	1	10142	1049	37	1		1	MYOF	10	95069804	Silent	SNP	G	TCGA-CN-6023-01A-11D-1683-08	51756960	95069804	40464943	67	16009											
GSTO1	9446	broad.mit.edu	37	chr10	106027062	106027062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatggcagccatgaaggaaGatcccacagtctcagccctg	11	6	12	12	0	1	2	1	1	1	1	3	4	2	4	3	3	2	1	3	3	2	0			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:106027062G>A	uc001kya.2	+	6	634	c.625G>A	c.(625-627)GAT>AAT	p.D209N	GSTO2_uc001kyb.2_5'Flank	NM_004832	NP_004823	P78417	GSTO1_HUMAN	glutathione-S-transferase omega 1	209	GST C-terminal.				xenobiotic metabolic process	cytosol	glutathione transferase activity|monodehydroascorbate reductase (NADH) activity				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;8.07e-10)|all cancers(201;2.72e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0147)	Glutathione(DB00143)	CATGAAGGAAGATCCCACAGT	0.493													15	30					0	0	0	0	A	106027062	A	A	106027062	3	1	80	1	0	0	0	0	1	0	0	0	6881	942	33	2	647	2	GSTO1	10	106027062	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	10957258	106027062	29507685	68	16010											
SHOC2	8036	broad.mit.edu	37	chr10	112724421	112724421	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaatgccgggaagagaattCaatgcgtttggacttatcca	13	10	10	8	2	1	1	1	0	0	1	2	4	2	3	2	2	2	1	2	2	5	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:112724421C>G	uc001kzl.3	+	2	654	c.305C>G	c.(304-306)TCA>TGA	p.S102*	SHOC2_uc009xxx.2_Nonsense_Mutation_p.S102*|SHOC2_uc010qrg.1_Intron|SHOC2_uc001kzn.2_Nonsense_Mutation_p.S102*	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	102	LRR 1.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		GAAGAGAATTCAATGCGTTTG	0.383													16	63					0	0	0	0	G	112724421	G	G	112724421	4	3	80	1	0	0	0	0	0	1	0	0	14352	838	29	2	307	2	SHOC2	10	112724421	Nonsense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	6697359	112724421	22810326	69	16011											
TRIM68	55128	broad.mit.edu	37	chr11	4626315	4626315	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttccatctctcaccttgtaCtcccaggcaacatcctccat	8	12	3	18	0	2	0	1	0	1	0	7	0	6	0	5	1	2	2	5	1	2	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr11:4626315C>G	uc001lzf.1	-	2	658	c.420G>C	c.(418-420)GAG>GAC	p.E140D	TRIM68_uc001lzg.1_5'UTR|TRIM68_uc010qyj.1_Intron|TRIM68_uc009yek.1_Missense_Mutation_p.E140D	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	140					protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		TCACCTTGTACTCCCAGGCAA	0.547													5	29					0	0	0	0	G	4626315	G	G	4626315	3	3	80	1	0	0	0	0	1	0	0	0	16608	564	20	4	1061	4	TRIM68	11	4626315	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08		4626315	130380201	70	16012											
TMEM134	80194	broad.mit.edu	37	chr11	67232544	67232544	+	Frame_Shift_Del	DEL	T	-	-																															cacctggagagggggtcgccTccagtcccacgccgaccagg																										TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr11:67232544delT	uc001olq.1	-	5	502	c.434delA	c.(433-435)GAGfs	p.E145fs	TMEM134_uc001olp.1_Frame_Shift_Del_p.E136fs|TMEM134_uc001olr.1_Intron|TMEM134_uc001ols.1_RNA|TMEM134_uc001olt.1_RNA	NM_025124	NP_079400	Q9H6X4	TM134_HUMAN	transmembrane protein 134 isoform a	145	Extracellular (Potential).					integral to membrane					0						GGGGGTCGCCTCCAGTCCCAC	0.577													---	---	---								-	67232544	-	-	67232544	7	5	80	1	0	1	0	1	0	0	0	0	16116	1551	54	0	165	0	TMEM134	11	67232544	Frame_Shift_Del	DEL	T	TCGA-CN-6023-01A-11D-1683-08	62606229	67232544	67773972	71	16013											
KLRC4	8302	broad.mit.edu	37	chr12	10560266	10560266	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattatctatagaaagcagaTcagagttcttcgaagcacag	15	10	8	8	1	3	3	1	0	2	3	4	4	3	3	0	0	2	3	0	0	5	5			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:10560266T>C	uc001qye.2	-	4	645	c.463A>G	c.(463-465)ATC>GTC	p.I155V	KLRK1_uc001qyc.2_5'UTR|KLRK1_uc009zhk.2_5'UTR|KLRK1_uc001qyd.2_5'UTR	NM_013431	NP_038459	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C,	155	Extracellular (Potential).				cellular defense response	integral to membrane	binding|receptor activity				0						AGAAAGCAGATCAGAGTTCTT	0.299													56	109					0	0	0	0	C	10560266	C	C	10560266	3	2	80	1	0	0	0	0	1	0	0	0	8457	1435	50	5	17	5	KLRC4	12	10560266	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08		10560266	123291629	72	16014											
MLL2	8085	broad.mit.edu	37	chr12	49428364	49428364	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tactcccacctgaccacttaCctggccactcccagctgcca	8	8	5	20	0	0	1	0	1	0	0	2	1	2	1	7	1	4	1	7	1	2	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:49428364C>T	uc001rta.3	-	36	10440	c.10440_splice	c.e36+1	p.Q3480_splice		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2						chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGACCACTTACCTGGCCACTC	0.562			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			4	11					0	0	0	0	T	49428364	T	T	49428364	5	4	80	1	0	0	0	0	0	0	1	0	9674	521	18	4	6248	4	MLL2	12	49428364	Splice_Site	SNP	C	TCGA-CN-6023-01A-11D-1683-08	38868098	49428364	84423531	73	16015											
KCNH3	23416	broad.mit.edu	37	chr12	49934900	49934900	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcaaggctgagctgatcCtgtaccggaagagcggtgag	10	8	15	8	2	1	4	1	3	0	1	2	5	2	5	2	3	3	4	2	3	3	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:49934900C>T	uc001ruh.1	+	2	555	c.295C>T	c.(295-297)CTG>TTG	p.L99L	KCNH3_uc010smj.1_Silent_p.L39L	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	99	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						TGAGCTGATCCTGTACCGGAA	0.622													5	45					0	0	0	0	T	49934900	T	T	49934900	2	4	80	1	0	0	0	0	0	0	0	1	8072	680	24	4		4	KCNH3	12	49934900	Silent	SNP	C	TCGA-CN-6023-01A-11D-1683-08	506536	49934900	83916995	74	16016											
PA2G4	5036	broad.mit.edu	37	chr12	56504208	56504208	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accatgaaaaagctgaatttGaggtacatgaagtatatgct	16	11	9	5	0	0	4	0	4	0	0	0	4	0	4	1	1	3	4	1	1	7	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:56504208G>A	uc001sjm.2	+	8	1074	c.655G>A	c.(655-657)GAG>AAG	p.E219K	PA2G4_uc009zol.2_Missense_Mutation_p.E219K|PA2G4_uc009zom.2_Missense_Mutation_p.E219K	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	219					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			AGCTGAATTTGAGGTACATGA	0.343													7	55					0	0	0	0	A	56504208	A	A	56504208	3	1	80	1	0	0	0	0	1	0	0	0	11415	1291	45	2	685	2	PA2G4	12	56504208	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	6569308	56504208	77347687	75	16017											
ZFC3H1	196441	broad.mit.edu	37	chr12	72056924	72056924	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcctcgcccccgactccagCgactcccaccccggtaaggc	6	5	8	22	4	0	0	0	0	0	0	4	2	3	0	7	2	1	1	7	2	1	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:72056924C>A	uc001swo.2	-	1	826	c.467G>T	c.(466-468)CGC>CTC	p.R156L	ZFC3H1_uc010sts.1_Missense_Mutation_p.R156L|ZFC3H1_uc001swp.2_Missense_Mutation_p.R156L|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	156					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						CCGACTCCAGCGACTCCCACC	0.667													13	126					0.000308642	0.000325213	1	0	A	72056924	A	A	72056924	3	1	80	1	0	0	0	0	1	0	0	0	17700	768	27	3	5642	3	ZFC3H1	12	72056924	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	15552716	72056924	61794971	76	16018											
OAS3	4940	broad.mit.edu	37	chr12	113388618	113388618	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccgcgcagagatccttgatGagatgcgagcgcagctagaa	11	6	14	10	4	0	4	0	2	0	3	1	7	1	4	2	0	3	3	2	0	2	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:113388618G>A	uc001tug.2	+	7	1582	c.1495G>A	c.(1495-1497)GAG>AAG	p.E499K		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	499	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						GATCCTTGATGAGATGCGAGC	0.572													32	55					0	0	0	0	A	113388618	A	A	113388618	3	1	80	1	0	0	0	0	1	0	0	0	10855	1291	45	2	1521	2	OAS3	12	113388618	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	41331694	113388618	20463277	77	16019											
N4BP2L2	10443	broad.mit.edu	37	chr13	33017607	33017607	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtgattgattttagttgtaTacacttgttcctctcttaaa	10	19	6	6	0	1	2	0	2	1	0	3	2	2	2	1	0	1	3	1	0	5	9			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr13:33017607T>A	uc010abe.1	-	7	1089	c.1067A>T	c.(1066-1068)TAT>TTT	p.Y356F	N4BP2L2_uc001uug.2_Missense_Mutation_p.Y239F|N4BP2L2_uc010abd.1_Missense_Mutation_p.Y269F|N4BP2L2_uc001uuh.2_Missense_Mutation_p.Y187F|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Missense_Mutation_p.Y341F	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TTTAGTTGTATACACTTGTTC	0.378													6	18					0	0	0	0	A	33017607	A	A	33017607	3	1	80	1	0	0	0	0	1	0	0	0	10165	1406	49	5	1203	5	N4BP2L2	13	33017607	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08		33017607	82152271	78	16020											
MYCBP2	23077	broad.mit.edu	37	chr13	77751900	77751900	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacatcatcaaccaacacctCtaattcatattcatgaattc	15	13	1	12	0	5	1	4	1	1	0	6	1	5	1	2	0	3	0	2	0	6	6			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr13:77751900C>T	uc001vkf.2	-	36	5300	c.5209G>A	c.(5209-5211)GAG>AAG	p.E1737K	MYCBP2_uc010aev.2_Missense_Mutation_p.E1141K	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1737					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACCAACACCTCTAATTCATAT	0.398													20	16					0	0	0	0	T	77751900	T	T	77751900	3	4	80	1	0	0	0	0	1	0	0	0	10071	922	32	2	8909	2	MYCBP2	13	77751900	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	44734293	77751900	37417978	79	16021											
FLJ10357	55701	broad.mit.edu	37	chr14	21543067	21543067	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcgaggggctcttagccGaggaggggacagtgccccac	8	5	17	11	2	1	0	0	0	1	0	2	4	1	2	3	6	2	1	3	6	1	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr14:21543067G>T	uc001vzp.2	+	3	1207	c.1178G>T	c.(1177-1179)CGA>CTA	p.R393L	FLJ10357_uc001vzn.1_Missense_Mutation_p.R393L|FLJ10357_uc001vzo.1_Intron|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_5'UTR	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	393	Gly-rich.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		GCTCTTAGCCGAGGAGGGGAC	0.607													13	32					2.61681e-11	2.99883e-11	1	0	T	21543067	T	T	21543067	3	4	80	1	0	0	0	0	1	0	0	0	5958	1058	37	3	1188	3	FLJ10357	14	21543067	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08		21543067	85806473	80	16022											
LRFN5	145581	broad.mit.edu	37	chr14	42356226	42356226	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatttgatactgaacaacaAtcagctgactttaatttcct	13	15	4	9	0	2	3	2	3	0	0	3	3	3	3	1	0	4	1	1	0	5	5			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr14:42356226A>G	uc001wvm.2	+	3	1596	c.398A>G	c.(397-399)AAT>AGT	p.N133S	LRFN5_uc010ana.2_Missense_Mutation_p.N133S	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	133	Extracellular (Potential).|LRR 4.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CTGAACAACAATCAGCTGACT	0.373										HNSCC(30;0.082)			15	47					0	0	0	0	G	42356226	G	G	42356226	3	3	80	1	0	0	0	0	1	0	0	0	8991	101	4	5	400	5	LRFN5	14	42356226	Missense_Mutation	SNP	A	TCGA-CN-6023-01A-11D-1683-08	20813159	42356226	64993314	81	16023											
DAAM1	23002	broad.mit.edu	37	chr14	59798071	59798071	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccccctccaccgcctcccCtccctccaggtggccctcct	2	9	5	25	1	0	0	0	0	0	0	6	0	6	0	11	2	0	0	11	2	0	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr14:59798071C>G	uc001xdz.1	+	14	1830	c.1705C>G	c.(1705-1707)CTC>GTC	p.L569V	DAAM1_uc001xea.1_Missense_Mutation_p.L569V	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	569	FH1.|Pro-rich.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		accgcctcccctccctccagg	0.453													8	19					0	0	0	0	G	59798071	G	G	59798071	3	3	80	1	0	0	0	0	1	0	0	0	4232	681	24	4	1755	4	DAAM1	14	59798071	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	17441845	59798071	47551469	82	16024											
SPTB	6710	broad.mit.edu	37	chr14	65242099	65242099	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctcaacccgcggcgtatggCccagaatctcattctgcagt	8	9	9	15	3	3	1	2	0	2	1	4	1	3	1	3	2	2	2	3	2	3	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr14:65242099C>A	uc001xht.2	-	22	4640	c.4586G>T	c.(4585-4587)GGC>GTC	p.G1529V	SPTB_uc001xhr.2_Missense_Mutation_p.G1529V|SPTB_uc001xhs.2_Missense_Mutation_p.G1529V|SPTB_uc001xhu.2_Missense_Mutation_p.G1529V|SPTB_uc010aqi.2_Missense_Mutation_p.G190V	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1529	Spectrin 12.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CGGCGTATGGCCCAGAATCTC	0.662													15	13					1.15088e-07	1.26355e-07	1	0	A	65242099	A	A	65242099	3	1	80	1	0	0	0	0	1	0	0	0	15184	739	26	4	2525	4	SPTB	14	65242099	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	5444028	65242099	42107441	83	16025											
MAX	4149	broad.mit.edu	37	chr14	65544653	65544653	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctgctccagaagagcattCtgccgcttgaggtcgtcaat	8	11	11	11	2	2	3	1	1	1	2	4	3	3	3	2	1	4	4	2	1	2	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr14:65544653C>G	uc001xif.1	-	4	443	c.273G>C	c.(271-273)CAG>CAC	p.Q91H	MAX_uc001xic.1_Intron|MAX_uc001xie.1_Missense_Mutation_p.Q91H|MAX_uc010aql.1_Intron|MAX_uc001xig.1_Missense_Mutation_p.Q82H|MAX_uc001xih.1_RNA|MAX_uc001xii.1_Missense_Mutation_p.Q82H|MAX_uc001xij.1_Missense_Mutation_p.Q91H	NM_002382	NP_002373	P61244	MAX_HUMAN	MAX protein isoform a	91	Leucine-zipper.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GAAGAGCATTCTGCCGCTTGA	0.567													18	32					0	0	0	0	G	65544653	G	G	65544653	3	3	80	1	0	0	0	0	1	0	0	0	9392	912	32	2	433	2	MAX	14	65544653	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	302554	65544653	41804887	84	16026											
SLC12A6	9990	broad.mit.edu	37	chr15	34628812	34628812	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctgacaaacctggaatgtCatcgatctttgtcggtgtca	9	13	10	9	2	4	1	2	1	2	0	6	3	4	2	1	2	1	0	1	2	2	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr15:34628812C>G	uc001zhw.2	-	1	234	c.70G>C	c.(70-72)GAC>CAC	p.D24H	SLC12A6_uc001zhx.2_Missense_Mutation_p.D24H|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Intron|SLC12A6_uc001zib.2_Missense_Mutation_p.D15H|SLC12A6_uc001zic.2_Missense_Mutation_p.D24H|SLC12A6_uc010bau.2_Missense_Mutation_p.D24H|SLC12A6_uc001zid.2_Intron	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	24	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CCTGGAATGTCATCGATCTTT	0.488													14	21					0	0	0	0	G	34628812	G	G	34628812	3	3	80	1	0	0	0	0	1	0	0	0	14452	826	29	2	3604	2	SLC12A6	15	34628812	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08		34628812	67902580	85	16027											
PRSS22	64063	broad.mit.edu	37	chr16	2905798	2905798	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgggaccgagagccagggttCcccagctgccaggcccccag	7	4	14	16	1	0	1	0	0	0	1	1	3	1	2	7	3	3	2	7	3	0	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:2905798C>T	uc002cry.1	-	4	402	c.336G>A	c.(334-336)GGG>GGA	p.G112G	PRSS22_uc002crz.1_Intron	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	112	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						AGCCAGGGTTCCCCAGCTGCC	0.617													6	28					0	0	0	0	T	2905798	T	T	2905798	2	4	80	1	0	0	0	0	0	0	0	1	12681	842	30	2		2	PRSS22	16	2905798	Silent	SNP	C	TCGA-CN-6023-01A-11D-1683-08		2905798	87448955	86	16028											
COG7	91949	broad.mit.edu	37	chr16	23444886	23444886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtagcccactggatttGtgtgtgccaagcaccaagca	9	10	11	11	0	0	0	0	0	0	0	0	1	0	1	3	1	4	3	3	1	3	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:23444886G>C	uc002dlo.2	-	6	978	c.790C>G	c.(790-792)CAA>GAA	p.Q264E		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	264					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		CACTGGATTTGTGTGTGCCAA	0.547													3	40					0	0	0	0	C	23444886	C	C	23444886	3	2	80	1	0	0	0	0	1	0	0	0	3678	1386	48	4	1570	4	COG7	16	23444886	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	20539088	23444886	66909867	87	16029											
GTF3C1	2975	broad.mit.edu	37	chr16	27472703	27472703	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacttgttccagttgacctCgtgggggaacacacggccca	8	8	11	14	2	0	1	0	1	0	0	2	2	1	2	4	3	1	2	4	3	1	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:27472703C>T	uc002dov.1	-	37	6338	c.6298G>A	c.(6298-6300)GAG>AAG	p.E2100K	GTF3C1_uc002dou.2_Missense_Mutation_p.E2075K	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	2100						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CAGTTGACCTCGTGGGGGAAC	0.652													10	40					0	0	0	0	T	27472703	T	T	27472703	3	4	80	1	0	0	0	0	1	0	0	0	6911	893	31	1	35	1	GTF3C1	16	27472703	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	4027817	27472703	62882050	88	16030											
ZNF768	79724	broad.mit.edu	37	chr16	30537124	30537124	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggctctgggattcaaactCagggctctgagaatctgatt	10	11	12	8	0	5	2	2	2	3	1	5	4	5	3	0	3	1	2	0	3	2	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:30537124C>T	uc002dyk.3	-	2	513	c.337G>A	c.(337-339)GAG>AAG	p.E113K	ZNF768_uc010vex.1_Missense_Mutation_p.E82K|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.E82K	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	113	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						GATTCAAACTCAGGGCTCTGA	0.587													14	60					0	0	0	0	T	30537124	T	T	30537124	3	4	80	1	0	0	0	0	1	0	0	0	18208	835	29	2	1289	2	ZNF768	16	30537124	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	3064421	30537124	59817629	89	16031											
ZNF768	79724	broad.mit.edu	37	chr16	30537662	30537662	+	Missense_Mutation	SNP	C	G	G																															ctcacctctgaggtacccttCggggctcctcatttcgtcag																										TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:30537662C>G	uc002dyk.3	-	1	249	c.73G>C	c.(73-75)GAA>CAA	p.E25Q	ZNF768_uc010vex.1_Intron|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Intron	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	25					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						AGGTACCCTTCGGGGCTCCTC	0.711													4	22					0	0	0	0	G	30537662	G	G	30537662	3	3	80	1	0	0	0	0	1	0	0	0	18208	893	31	3	1557	3	ZNF768	16	30537662	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	538	30537662	59817091	90	16032	33	2									
ZNF768	79724	broad.mit.edu	37	chr16	30537672	30537672	+	Missense_Mutation	SNP	C	T	T																															aggtacccttcggggctcctCatttcgtcagaactctgcac																										TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:30537672C>T	uc002dyk.3	-	1	239	c.63G>A	c.(61-63)ATG>ATA	p.M21I	ZNF768_uc010vex.1_Intron|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Intron	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	21					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						CGGGGCTCCTCATTTCGTCAG	0.701													5	23					0	0	0	0	T	30537672	T	T	30537672	3	4	80	1	0	0	0	0	1	0	0	0	18208	826	29	2	1567	2	ZNF768	16	30537672	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	10	30537672	59817081	91	16033	33	2									
MMP2	4313	broad.mit.edu	37	chr16	55523685	55523685	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggaaagatgtggtgtgcgAccacagccaactacgatgat	13	7	12	9	3	0	2	0	1	0	1	0	5	0	3	2	2	4	0	2	2	3	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:55523685A>G	uc002ehz.3	+	7	1440	c.1129A>G	c.(1129-1131)ACC>GCC	p.T377A	MMP2_uc010vhd.1_Missense_Mutation_p.T301A|MMP2_uc010ccc.2_Missense_Mutation_p.T327A	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	377	Fibronectin type-II 3.|Collagen-binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	GTGGTGTGCGACCACAGCCAA	0.592													8	56					0	0	0	0	G	55523685	G	G	55523685	3	3	80	1	0	0	0	0	1	0	0	0	9711	275	10	5	1162	5	MMP2	16	55523685	Missense_Mutation	SNP	A	TCGA-CN-6023-01A-11D-1683-08	24986013	55523685	34831068	92	16034											
ZNF821	55565	broad.mit.edu	37	chr16	71894083	71894088	+	In_Frame_Del	DEL	CATTTT	-	-																															tgagctcgcaacatcatgtcCattttctccagcctcctctt																										TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:71894083_71894088delCATTTT	uc010vmj.1	-	7	1448_1453	c.1072_1077delAAAATG	c.(1072-1077)AAAATGdel	p.KM358del	ATXN1L_uc010vmi.1_Intron|ZNF821_uc002fbe.2_In_Frame_Del_p.KM208del|ZNF821_uc002fbf.2_In_Frame_Del_p.KM316del|ZNF821_uc002fbg.3_In_Frame_Del_p.KM208del|ZNF821_uc002fbh.3_In_Frame_Del_p.KM316del|ZNF821_uc002fbi.3_In_Frame_Del_p.KM155del	NM_017530	NP_060000	O75541	ZN821_HUMAN	zinc finger protein 821	358_359	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACATCATGTCCATTTTCTCCAGCCTC	0.587													---	---	---								-	71894088	-	-	71894083	7	5	80	1	0	1	0	1	0	0	0	0	18245	594	21	0	165	0	ZNF821	16	71894083	In_Frame_Del	DEL	CATTTT	TCGA-CN-6023-01A-11D-1683-08	16370398	71894083	18460670	93	16035											
DYNLRB2	83657	broad.mit.edu	37	chr16	80583380	80583380	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaaattaaatttcataataGgtattcccatccgaacaacc	17	11	3	10	1	1	0	1	0	0	0	3	1	3	0	3	1	2	1	3	1	9	6			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:80583380G>C	uc002ffo.2	+	5	200	c.80_splice	c.e5-1	p.G27_splice	DYNLRB2_uc002ffp.2_Splice_Site|DYNLRB2_uc002ffq.2_RNA	NM_130897	NP_570967	Q8TF09	DLRB2_HUMAN	dynein, light chain, roadblock-type 2						microtubule-based movement|transport	cytoplasmic dynein complex|microtubule	microtubule motor activity				0						TTTCATAATAGGTATTCCCAT	0.338													4	20					0	0	0	0	C	80583380	C	C	80583380	5	2	80	1	0	0	0	0	0	0	1	0	4873	1014	35	4	89	4	DYNLRB2	16	80583380	Splice_Site	SNP	G	TCGA-CN-6023-01A-11D-1683-08	8689297	80583380	9771373	94	16036											
KIAA0664	23277	broad.mit.edu	37	chr17	2604528	2604528	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttaggaagcgggggctggCgggcttggggttgaagtgat	6	9	21	5	2	0	2	0	2	0	0	0	3	0	3	0	7	1	4	0	7	3	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:2604528C>T	uc002fuy.1	-	7	903	c.817G>A	c.(817-819)GCC>ACC	p.A273T	KIAA0664_uc002fux.1_Missense_Mutation_p.A205T	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	273							binding			breast(2)	2						CGGGGGCTGGCGGGCTTGGGG	0.622													5	17					0	0	0	0	T	2604528	T	T	2604528	3	4	80	1	0	0	0	0	1	0	0	0	8228	768	27	1	3192	1	KIAA0664	17	2604528	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08		2604528	78590682	95	16037											
MYBBP1A	10514	broad.mit.edu	37	chr17	4455195	4455195	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttagcagtgcacacgtgctCcccgtaatggcggatcacgt	8	9	11	13	4	1	0	1	0	0	0	2	1	2	1	2	2	3	4	2	2	2	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:4455195C>T	uc002fyb.3	-	8	1065	c.1003G>A	c.(1003-1005)GAG>AAG	p.E335K	MYBBP1A_uc002fxz.3_Missense_Mutation_p.E335K	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	335	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						CACACGTGCTCCCCGTAATGG	0.627													6	74					0	0	0	0	T	4455195	T	T	4455195	3	4	80	1	0	0	0	0	1	0	0	0	10061	864	30	2	3099	2	MYBBP1A	17	4455195	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	1850667	4455195	76740015	96	16038											
MINK1	50488	broad.mit.edu	37	chr17	4789867	4789867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccacggagcggcaggtcCgcatccagcttaaggaccac	10	4	12	15	3	0	0	0	0	0	0	2	2	2	2	4	4	3	3	4	4	1	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:4789867C>T	uc010vsl.1	+	10	1091	c.895C>T	c.(895-897)CGC>TGC	p.R299C	MINK1_uc010vsk.1_Missense_Mutation_p.R299C|MINK1_uc010vsm.1_Missense_Mutation_p.R299C|MINK1_uc010vsn.1_Missense_Mutation_p.R299C|MINK1_uc010vso.1_Missense_Mutation_p.R244C|MINK1_uc010vsp.1_5'UTR	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	299					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						GCGGCAGGTCCGCATCCAGCT	0.602													20	46					0	0	0	0	T	4789867	T	T	4789867	3	4	80	1	0	0	0	0	1	0	0	0	9640	652	23	1	672	1	MINK1	17	4789867	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	334672	4789867	76405343	97	16039											
TP53	7157	broad.mit.edu	37	chr17	7577548	7577548	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgggcctccggttcatgcCgcccatgcaggaactgttac	7	9	12	13	2	1	0	1	0	0	0	2	2	2	1	4	3	4	3	4	3	2	2	rs28934575		TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	21					0	0	0	0	T	7577548	T	T	7577548	3	4	80	1	0	0	0	0	1	0	0	0	16448	652	23	1	557	1	TP53	17	7577548	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	2787681	7577548	73617662	98	16040											
PHF12	57649	broad.mit.edu	37	chr17	27248731	27248731	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacgtgaagcagactttgaCgggtaagggaacgagaccat	14	6	13	8	3	0	4	0	2	0	2	0	6	0	5	1	2	2	2	1	2	3	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:27248731C>A	uc002hdg.1	-	5	1341	c.811G>T	c.(811-813)GTC>TTC	p.V271F	PHF12_uc010wbb.1_Missense_Mutation_p.V253F|PHF12_uc002hdi.1_Missense_Mutation_p.V267F|PHF12_uc002hdj.1_Missense_Mutation_p.V271F|PHF12_uc010crw.1_5'UTR|PHF12_uc002hdh.1_Missense_Mutation_p.V54F	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	271	PHD-type 2; atypical.|Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			CAGACTTTGACGGGTAAGGGA	0.408													29	73					2.70662e-09	3.07927e-09	1	0	A	27248731	A	A	27248731	3	1	80	1	0	0	0	0	1	0	0	0	11878	536	19	3	2273	3	PHF12	17	27248731	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	19671183	27248731	53946479	99	16041											
MYO1D	4642	broad.mit.edu	37	chr17	31094761	31094761	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgaattcggcagcatcatTgatagaagactggggatgaa	13	10	12	6	1	2	5	1	3	1	2	3	6	2	6	0	3	1	2	0	3	4	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:31094761T>C	uc002hho.1	-	7	736	c.724A>G	c.(724-726)AAT>GAT	p.N242D	MYO1D_uc002hhp.1_Missense_Mutation_p.N242D|MYO1D_uc010wcb.1_Missense_Mutation_p.N242D	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	242	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			GCAGCATCATTGATAGAAGAC	0.353													24	39					0	0	0	0	C	31094761	C	C	31094761	3	2	80	1	0	0	0	0	1	0	0	0	10124	1812	63	5	2360	5	MYO1D	17	31094761	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08	3846030	31094761	50100449	100	16042											
RFFL	117584	broad.mit.edu	37	chr17	33353416	33353416	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggccgtgtttgcaaagtGagccccacaggacttgcagc	8	8	12	13	1	0	1	0	1	0	0	0	2	0	2	4	2	4	3	4	2	1	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:33353416G>C	uc002hin.1	-	2	330	c.157C>G	c.(157-159)CAC>GAC	p.H53D	RFFL_uc002hiq.2_Intron|RFFL_uc002him.1_Missense_Mutation_p.H53D|RFFL_uc010cti.1_Missense_Mutation_p.H59D|RFFL_uc002hip.1_Missense_Mutation_p.H53D|RFFL_uc002hio.1_Missense_Mutation_p.H53D	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	53	FYVE-type.				apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TTTGCAAAGTGAGCCCCACAG	0.597													6	24					0	0	0	0	C	33353416	C	C	33353416	3	2	80	1	0	0	0	0	1	0	0	0	13315	1290	45	2	958	2	RFFL	17	33353416	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	2258655	33353416	47841794	101	16043											
CCL23	6368	broad.mit.edu	37	chr17	34340266	34340266	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctggtcttgatccgtgtgtCcagcttcagcattctcacgc	5	13	9	14	2	3	1	2	1	2	0	6	1	5	1	3	1	2	2	3	1	0	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:34340266C>T	uc002hkt.1	-	4	405	c.334G>A	c.(334-336)GAC>AAC	p.D112N	CCL23_uc002hks.1_Missense_Mutation_p.D129N	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	112					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	ATCCGTGTGTCCAGCTTCAGC	0.498													6	33					0	0	0	0	T	34340266	T	T	34340266	3	4	80	1	0	0	0	0	1	0	0	0	2908	855	30	2	32	2	CCL23	17	34340266	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	986850	34340266	46854944	102	16044											
TEX2	55852	broad.mit.edu	37	chr17	62248511	62248511	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggatttttggcacagccaCgcccatgtcaagttccgtca	9	10	10	12	2	2	0	2	0	0	0	3	2	3	1	3	2	1	2	3	2	1	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:62248511C>G	uc002jec.2	-	7	2793	c.2620G>C	c.(2620-2622)GTG>CTG	p.V874L	TEX2_uc002jed.2_Missense_Mutation_p.V881L|TEX2_uc002jee.2_Missense_Mutation_p.V874L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	874					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		GGCACAGCCACGCCCATGTCA	0.448													5	35					0	0	0	0	G	62248511	G	G	62248511	3	3	80	1	0	0	0	0	1	0	0	0	15847	536	19	3	787	3	TEX2	17	62248511	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	27908245	62248511	18946699	103	16045											
RFNG	5986	broad.mit.edu	37	chr17	80007651	80007651	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgcccaggagcccctccaCgatgtagccaactgtgcagt	8	6	12	15	2	0	0	0	0	0	0	1	2	1	1	5	2	4	2	5	2	2	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:80007651C>T	uc002kdj.2	-	6	738	c.730G>A	c.(730-732)GTG>ATG	p.V244M	RFNG_uc002kdh.2_Missense_Mutation_p.V29M|GPS1_uc002kdk.1_5'Flank|GPS1_uc002kdl.1_5'Flank|GPS1_uc010dij.1_5'Flank|GPS1_uc002kdm.1_5'Flank|GPS1_uc002kdn.1_5'Flank|GPS1_uc002kdo.1_5'Flank|GPS1_uc010wvh.1_5'Flank	NM_002917	NP_002908	Q9Y644	RFNG_HUMAN	radical fringe	244	Lumenal (Potential).				cell differentiation|nervous system development|organ morphogenesis|pattern specification process	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			AGCCCCTCCACGATGTAGCCA	0.667													7	18					0	0	0	0	T	80007651	T	T	80007651	3	4	80	1	0	0	0	0	1	0	0	0	13317	536	19	1	277	1	RFNG	17	80007651	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	17759140	80007651	1187559	104	16046											
CCDC57	284001	broad.mit.edu	37	chr17	80129690	80129690	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccagagttttaaacttatgcTttagagttcgtatttctgct	9	18	7	7	1	1	2	0	0	1	2	2	2	1	2	1	0	3	5	1	0	5	8			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:80129690T>C	uc002kdz.1	-	13	2124	c.1769A>G	c.(1768-1770)AAG>AGG	p.K590R	CCDC57_uc002kdx.1_Missense_Mutation_p.K590R|CCDC57_uc010dik.1_Missense_Mutation_p.K98R	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	590	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			AAACTTATGCTTTAGAGTTCG	0.448													19	68					0	0	0	0	C	80129690	C	C	80129690	3	2	80	1	0	0	0	0	1	0	0	0	2840	1609	56	5	1002	5	CCDC57	17	80129690	Missense_Mutation	SNP	T	TCGA-CN-6023-01A-11D-1683-08	122039	80129690	1065520	105	16047											
PTPN2	5771	broad.mit.edu	37	chr18	12817283	12817283	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactttaaacaagaaattgaGaaatgaagctggtgattcag	17	10	9	5	0	1	4	1	3	0	2	1	5	1	4	0	1	2	1	0	1	6	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr18:12817283G>A	uc002krp.2	-	6	771	c.577C>T	c.(577-579)CTC>TTC	p.L193F	PTPN2_uc002krl.2_Missense_Mutation_p.L193F|PTPN2_uc002krn.2_Missense_Mutation_p.L216F|PTPN2_uc002kro.2_Missense_Mutation_p.L193F|PTPN2_uc002krm.2_Missense_Mutation_p.L193F	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	193	Tyrosine-protein phosphatase.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)				AAGAAATTGAGAAATGAAGCT	0.453													19	64					0	0	0	0	A	12817283	A	A	12817283	3	1	80	1	0	0	0	0	1	0	0	0	12848	942	33	2	712	2	PTPN2	18	12817283	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08		12817283	65259965	106	16048											
ESCO1	114799	broad.mit.edu	37	chr18	19154819	19154819	+	Translation_Start_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catcattcctgagtaatgacTttcttttctgagtagttttg	8	19	7	7	0	3	3	1	3	2	0	4	3	4	3	1	0	0	3	1	0	2	8			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr18:19154819T>A	uc002kth.1	-	4	920	c.-14A>T	c.(-16--12)AAAGT>AATGT		ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1						cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						GAGTAATGACTTTCTTTTCTG	0.358													4	15					0	0	0	0	A	19154819	A	A	19154819	1	1	80	1	0	0	0	0	0	0	0	0	5272	1624	56	5		5	ESCO1	18	19154819	Translation_Start_Site	SNP	T	TCGA-CN-6023-01A-11D-1683-08	6337536	19154819	58922429	107	16049											
CHST9	83539	broad.mit.edu	37	chr18	24497019	24497019	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaactcctgaaggaaagacCttcgtttctcttgggtctcc	10	12	8	11	1	2	2	0	1	2	1	6	3	3	3	3	2	1	1	3	2	4	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr18:24497019C>A	uc002kwd.2	-	5	734	c.536G>T	c.(535-537)AGG>ATG	p.R179M	C18orf16_uc002kwb.2_Intron|C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_Missense_Mutation_p.R94M|CHST9_uc002kwe.2_Missense_Mutation_p.R179M	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	179	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					AAGGAAAGACCTTCGTTTCTC	0.383													17	82					1.15088e-07	1.26355e-07	1	0	A	24497019	A	A	24497019	3	1	80	1	0	0	0	0	1	0	0	0	3426	681	24	4	799	4	CHST9	18	24497019	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	5342200	24497019	53580229	108	16050											
HNRNPL	3191	broad.mit.edu	37	chr19	39329127	39329127	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgcggttcttggctgcctgCtctggggtggagaaccgatt	5	12	15	9	2	2	1	0	0	2	1	2	3	2	1	2	5	4	3	2	5	1	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr19:39329127C>T	uc010xul.1	-	10	1478	c.1467G>A	c.(1465-1467)GAG>GAA	p.E489E	HNRNPL_uc010ege.1_Intron|HNRNPL_uc002ojj.1_Silent_p.E145E|HNRNPL_uc002ojo.1_Silent_p.E67E|HNRNPL_uc002ojk.2_Silent_p.E145E|HNRNPL_uc002ojl.2_Silent_p.E145E|HNRNPL_uc010xum.1_Silent_p.E356E	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	489					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			TGGCTGCCTGCTCTGGGGTGG	0.572													5	21					0	0	0	0	T	39329127	T	T	39329127	2	4	80	1	0	0	0	0	0	0	0	1	7309	796	28	4		4	HNRNPL	19	39329127	Silent	SNP	C	TCGA-CN-6023-01A-11D-1683-08		39329127	19799856	109	16051											
NFKBIB	4793	broad.mit.edu	37	chr19	39399378	39399380	+	In_Frame_Del	DEL	ACG	-	-																															cctttgcccccaggatgaatAcgacgacattgtggttcaca																								rs141886159		TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr19:39399378_39399380delACG	uc002ojw.2	+	6	1035_1037	c.977_979delACG	c.(976-981)TACGAC>TAC	p.D328del	NFKBIB_uc002ojx.2_3'UTR|NFKBIB_uc002ojy.2_3'UTR	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	328					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CAGGATGAATACGACGACATTGT	0.596													---	---	---								-	39399380	-	-	39399378	7	5	80	1	0	1	0	1	0	0	0	0	10432	391	14	0	1047	0	NFKBIB	19	39399378	In_Frame_Del	DEL	ACG	TCGA-CN-6023-01A-11D-1683-08	70251	39399378	19729605	110	16052											
HNRNPUL1	11100	broad.mit.edu	37	chr19	41807560	41807560	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccgaacaataaagcgaacCgacgaggaagggaaggatgt	17	3	14	7	4	0	0	0	0	0	0	0	8	0	3	2	3	3	0	2	3	7	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr19:41807560C>T	uc002oqb.3	+	11	1927	c.1638C>T	c.(1636-1638)ACC>ACT	p.T546T	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Silent_p.T446T|HNRNPUL1_uc002oqa.3_Silent_p.T446T|HNRNPUL1_uc010ehm.2_Silent_p.T546T|HNRNPUL1_uc002oqc.3_Silent_p.T432T|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Silent_p.T446T|HNRNPUL1_uc010ehn.2_Silent_p.T446T|HNRNPUL1_uc010eho.2_Silent_p.T446T|HNRNPUL1_uc010xvy.1_Silent_p.T446T|HNRNPUL1_uc010ehp.2_Silent_p.T402T|HNRNPUL1_uc002oqf.3_5'Flank	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	546	Necessary for interaction with TP53.|Necessary for interaction with BRD7 and transcriptional activation.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						TAAAGCGAACCGACGAGGAAG	0.483													9	53					0	0	0	0	T	41807560	T	T	41807560	2	4	80	1	0	0	0	0	0	0	0	1	7313	639	23	1		1	HNRNPUL1	19	41807560	Silent	SNP	C	TCGA-CN-6023-01A-11D-1683-08	2408182	41807560	17321423	111	16053											
SEC23B	10483	broad.mit.edu	37	chr20	18511339	18511339	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctagaggctacatggtaatGggagattctttcaacacttc	11	12	9	9	0	2	2	1	0	1	2	3	3	2	2	1	3	2	2	1	3	4	6			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr20:18511339G>T	uc002wqz.1	+	10	1568	c.1125G>T	c.(1123-1125)ATG>ATT	p.M375I	SEC23B_uc002wra.1_Missense_Mutation_p.M375I|SEC23B_uc002wrb.1_Missense_Mutation_p.M375I|SEC23B_uc010zsb.1_Missense_Mutation_p.M357I|SEC23B_uc002wrc.1_Missense_Mutation_p.M375I	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	375					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						ACATGGTAATGGGAGATTCTT	0.343													6	73					1.06961e-07	1.19099e-07	1	0	T	18511339	T	T	18511339	3	4	80	1	0	0	0	0	1	0	0	0	14057	1348	47	4	1159	4	SEC23B	20	18511339	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08		18511339	44514181	112	16054											
NDRG3	57446	broad.mit.edu	37	chr20	35293461	35293461	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atacttaccacagcctcaacTgcaggcgaattgtcccctac	11	9	6	15	1	1	0	1	0	0	0	2	1	2	0	4	1	6	1	4	1	5	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr20:35293461T>G	uc002xfw.2	-	12	880	c.798A>C	c.(796-798)GCA>GCC	p.A266A	NDRG3_uc002xfx.2_Silent_p.A254A|NDRG3_uc010zvq.1_Silent_p.A171A|NDRG3_uc010zvr.1_Silent_p.A154A	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	266					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)				CAGCCTCAACTGCAGGCGAAT	0.358													46	93					0	0	0	0	G	35293461	G	G	35293461	2	3	80	1	0	0	0	0	0	0	0	1	10307	1567	55	5		5	NDRG3	20	35293461	Silent	SNP	T	TCGA-CN-6023-01A-11D-1683-08	16782122	35293461	27732059	113	16055											
C20orf132	140699	broad.mit.edu	37	chr20	35757571	35757571	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacacctcagccaggtgcCtggaaatcccaaagagcaag	13	5	9	14	0	1	1	1	0	0	1	3	2	3	2	5	2	3	1	5	2	3	0			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr20:35757571C>G	uc010zvu.1	-	16	1771	c.1680_splice	c.e16-1	p.R560_splice	C20orf132_uc002xgk.2_Splice_Site_p.R182_splice|C20orf132_uc002xgm.2_Intron|C20orf132_uc002xgn.2_Intron	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1												0		Myeloproliferative disorder(115;0.00878)				AGCCAGGTGCCTGGAAATCCC	0.512													10	14					0	0	0	0	G	35757571	G	G	35757571	5	3	80	1	0	0	0	0	0	0	1	0	2096	695	24	4	1535	4	C20orf132	20	35757571	Splice_Site	SNP	C	TCGA-CN-6023-01A-11D-1683-08	464110	35757571	27267949	114	16056											
CHD6	84181	broad.mit.edu	37	chr20	40040857	40040857	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgacatctaattttccaGgttctttacagcgtggcctc	8	14	8	11	1	2	1	0	1	2	0	4	1	3	1	2	2	3	2	2	2	2	6			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr20:40040857G>C	uc002xka.1	-	36	7356	c.7178C>G	c.(7177-7179)CCT>CGT	p.P2393R	CHD6_uc002xjz.1_5'UTR	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2393					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TAATTTTCCAGGTTCTTTACA	0.488													11	70					0	0	0	0	C	40040857	C	C	40040857	3	2	80	1	0	0	0	0	1	0	0	0	3344	1000	35	4	977	4	CHD6	20	40040857	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	4283286	40040857	22984663	115	16057											
MAGEB6	158809	broad.mit.edu	37	chrX	26212225	26212225	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatccgatgtggctgccaacGgccaagatgagaaaagtcca	14	6	11	10	2	0	2	0	1	0	2	2	4	2	2	4	2	2	1	4	2	5	0	rs140212002		TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:26212225G>T	uc004dbr.2	+	2	411	c.262G>T	c.(262-264)GGC>TGC	p.G88C	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	88	Ser-rich.									ovary(3)	3						GGCTGCCAACGGCCAAGATGA	0.542													10	18					2.80697e-09	3.17047e-09	1	0	T	26212225	T	T	26212225	3	4	80	1	0	0	0	0	1	0	0	0	9232	1116	39	3	264	3	MAGEB6	23	26212225	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08		26212225	129058335	116	16058											
MAGEB1	4112	broad.mit.edu	37	chrX	30268842	30268842	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagctgtgtcatgtaccGaatctgacgaaggtgccaaa	11	9	11	10	2	2	1	1	1	1	0	2	3	2	1	2	1	4	3	2	1	4	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:30268842G>T	uc004dcc.2	+	4	552	c.232G>T	c.(232-234)GAA>TAA	p.E78*	MAGEB1_uc004dcd.2_Nonsense_Mutation_p.E78*|MAGEB1_uc004dce.2_Nonsense_Mutation_p.E78*	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	78											0						GTCATGTACCGAATCTGACGA	0.552													5	8					1.23904e-05	1.32333e-05	1	0	T	30268842	T	T	30268842	4	4	80	1	0	0	0	0	0	1	0	0	9225	1059	37	3	234	3	MAGEB1	23	30268842	Nonsense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	4056617	30268842	125001718	117	16059											
DMD	1756	broad.mit.edu	37	chrX	31497125	31497125	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggctcctggtagagtttctcTagtccttccaaaggctgctc	6	13	10	12	0	1	1	0	0	1	1	6	1	4	1	3	3	1	5	3	3	3	4			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:31497125T>C	uc004dda.1	-	58	8887	c.8643A>G	c.(8641-8643)CTA>CTG	p.L2881L	DMD_uc004dcq.1_Silent_p.L152L|DMD_uc004dcr.1_Silent_p.L421L|DMD_uc004dcs.1_Silent_p.L421L|DMD_uc004dct.1_Silent_p.L421L|DMD_uc004dcu.1_Silent_p.L421L|DMD_uc004dcv.1_Silent_p.L421L|DMD_uc004dcw.2_Silent_p.L1537L|DMD_uc004dcx.2_Silent_p.L1540L|DMD_uc004dcz.2_Silent_p.L2758L|DMD_uc004dcy.1_Silent_p.L2877L|DMD_uc004ddb.1_Silent_p.L2873L	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2881	Spectrin 20.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGAGTTTCTCTAGTCCTTCCA	0.428													14	9					0	0	0	0	C	31497125	C	C	31497125	2	2	80	1	0	0	0	0	0	0	0	1	4602	1509	53	5		5	DMD	23	31497125	Silent	SNP	T	TCGA-CN-6023-01A-11D-1683-08	1228283	31497125	123773435	118	16060											
SMC1A	8243	broad.mit.edu	37	chrX	53421731	53421731	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagatcaccgtagtcaatCtcaatgagggcctctcgtgc	10	9	9	13	2	4	2	3	1	2	1	6	2	4	2	2	1	1	1	2	1	3	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:53421731C>G	uc004dsg.2	-	19	3009	c.2940G>C	c.(2938-2940)GAG>GAC	p.E980D	SMC1A_uc011moe.1_Missense_Mutation_p.E958D	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	980					cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						CGTAGTCAATCTCAATGAGGG	0.542													4	26					0	0	0	0	G	53421731	G	G	53421731	3	3	80	1	0	0	0	0	1	0	0	0	14845	912	32	2	789	2	SMC1A	23	53421731	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	21924606	53421731	101848829	119	16061											
XKRX	402415	broad.mit.edu	37	chrX	100169656	100169656	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccagttctgccctttgtCgacgagatctctgtctgcca	5	13	8	15	2	3	1	0	0	3	1	6	3	4	1	4	0	2	1	4	0	0	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:100169656C>A	uc004egn.2	-	3	1626	c.1021G>T	c.(1021-1023)GAC>TAC	p.D341Y	XKRX_uc011mre.1_Missense_Mutation_p.D137Y	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	341						integral to membrane|plasma membrane				breast(1)	1						TGCCCTTTGTCGACGAGATCT	0.478													60	66					5.08636e-23	6.0042e-23	1	0	A	100169656	A	A	100169656	3	1	80	1	0	0	0	0	1	0	0	0	17507	884	31	3	332	3	XKRX	23	100169656	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	46747925	100169656	55100904	120	16062											
BCORL1	63035	broad.mit.edu	37	chrX	129147536	129147536	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctctggctccagcgccacCgtcagtgcccacgctcatct	5	8	10	18	3	4	0	2	0	2	0	5	0	5	0	4	2	2	3	4	2	0	0			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:129147536C>T	uc004evb.1	+	4	902	c.788C>T	c.(787-789)CCG>CTG	p.P263L	BCORL1_uc010nrd.1_Missense_Mutation_p.P165L	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	263	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CCAGCGCCACCGTCAGTGCCC	0.627													16	49					0	0	0	0	T	129147536	T	T	129147536	3	4	80	1	0	0	0	0	1	0	0	0	1389	652	23	1	798	1	BCORL1	23	129147536	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	28977880	129147536	26123024	121	16063											
SLITRK4	139065	broad.mit.edu	37	chrX	142718314	142718314	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagttgcaattcaacgacaCggccaatgtgttccagaacc	12	8	8	13	2	1	1	1	0	0	1	2	2	2	1	4	1	3	3	4	1	4	3			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:142718314C>T	uc004fbx.2	-	2	987	c.611G>A	c.(610-612)CGT>CAT	p.R204H	SLITRK4_uc004fby.2_Missense_Mutation_p.R204H	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	204	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCAACGACACGGCCAATGTG	0.428													25	54					0	0	0	0	T	142718314	T	T	142718314	3	4	80	1	0	0	0	0	1	0	0	0	14809	536	19	1	1906	1	SLITRK4	23	142718314	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	13570778	142718314	12552246	122	16064											
PASD1	139135	broad.mit.edu	37	chrX	150817138	150817138	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgaaagccgtgtacgttgaAcccgctgctgctgctgctgc	7	10	12	12	3	0	2	0	2	0	0	0	2	0	2	2	0	8	7	2	0	3	2			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:150817138A>C	uc004fev.3	+	9	1013	c.681A>C	c.(679-681)GAA>GAC	p.E227D		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	227						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGTACGTTGAACCCgctgctg	0.353													10	74					0	0	0	0	C	150817138	C	C	150817138	3	2	80	1	0	0	0	0	1	0	0	0	11525	40	2	5	711	5	PASD1	23	150817138	Missense_Mutation	SNP	A	TCGA-CN-6023-01A-11D-1683-08	8098824	150817138	4453422	123	16065											
TAZ	6901	broad.mit.edu	37	chrX	153649016	153649016	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaaaatcactgtgctgatcgGgaagcccttcagtgccctgc	9	9	11	12	1	2	1	2	1	0	0	3	3	2	2	2	1	4	1	2	1	3	1			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:153649016G>A	uc004fkx.2	+	10	1023	c.719G>A	c.(718-720)GGG>GAG	p.G240E	TAZ_uc004fky.2_Missense_Mutation_p.G226E|TAZ_uc004fkz.2_RNA|TAZ_uc004fla.2_Missense_Mutation_p.G210E|TAZ_uc004flb.2_Missense_Mutation_p.G196E|TAZ_uc010nuy.2_Missense_Mutation_p.G244E|TAZ_uc004flc.3_Missense_Mutation_p.G210E	NM_000116	NP_000107	Q16635	TAZ_HUMAN	tafazzin isoform 1	240					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTGCTGATCGGGAAGCCCTTC	0.642													18	19					0	0	0	0	A	153649016	A	A	153649016	3	1	80	1	0	0	0	0	1	0	0	0	15662	1232	43	4	757	4	TAZ	23	153649016	Missense_Mutation	SNP	G	TCGA-CN-6023-01A-11D-1683-08	2831878	153649016	1621544	124	16066											
F8	2157	broad.mit.edu	37	chrX	154221234	154221234	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctctacatactagtagggctCcaatgaggcctgaattcaag	12	10	9	10	0	2	2	1	2	1	0	3	2	3	2	2	2	2	2	2	2	7	5			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:154221234C>G	uc004fmt.2	-	4	749	c.578G>C	c.(577-579)GGA>GCA	p.G193A	F8_uc011mzx.1_Missense_Mutation_p.G158A	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	193	Plastocyanin-like 1.|F5/8 type A 1.		G -> R (in HEMA; severe familial).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TAGTAGGGCTCCAATGAGGCC	0.413													3	79					0	0	0	0	G	154221234	G	G	154221234	3	3	80	1	0	0	0	0	1	0	0	0	5375	855	30	2	6597	2	F8	23	154221234	Missense_Mutation	SNP	C	TCGA-CN-6023-01A-11D-1683-08	572218	154221234	1049326	125	16067											
CDC20	991	broad.mit.edu	37	chr1	43825057	43825057	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcgccggcaggactccgggCcgaactcctggtcagtgagg	7	5	16	13	4	1	1	1	1	0	0	3	3	3	2	4	5	2	1	4	5	1	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:43825057C>T	uc001cix.2	+	2	272	c.171C>T	c.(169-171)GGC>GGT	p.G57G	CDC20_uc001ciy.2_Silent_p.G57G	NM_001255	NP_001246	Q12834	CDC20_HUMAN	cell division cycle 20	57					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGACTCCGGGCCGAACTCCTG	0.662													20	10					0	0	0	0	T	43825057	T	T	43825057	2	4	81	1	0	0	0	0	0	0	0	1	3074	726	26	4		4	CDC20	1	43825057	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08		43825057	205425564	1	16068											
MAST2	23139	broad.mit.edu	37	chr1	46295227	46295228	+	Frame_Shift_Del	DEL	TC	-	-																															gaaaccagtcccttggacagTctgcaccttctcttactgct																										TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:46295227_46295228delTC	uc001cov.2	+	3	725_726	c.442_443delTC	c.(442-444)TCTfs	p.S148fs	MAST2_uc001cow.2_Frame_Shift_Del_p.S148fs	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	148					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CCTTGGACAGTCTGCACCTTCT	0.446													---	---	---								-	46295228	-	-	46295227	7	5	81	1	0	1	0	1	0	0	0	0	9378	1667	58	0	452	0	MAST2	1	46295227	Frame_Shift_Del	DEL	TC	TCGA-CN-6024-01A-11D-1683-08	2470170	46295227	202955394	2	16069											
RAD54L	8438	broad.mit.edu	37	chr1	46739822	46739822	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccttcaggtacttatacgtCcgcctggatggcacgatgtc	7	11	10	13	3	1	0	1	0	0	0	3	2	2	1	3	3	2	2	3	3	3	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:46739822C>T	uc009vye.2	+	16	1737	c.1623C>T	c.(1621-1623)GTC>GTT	p.V541V	RAD54L_uc001cpl.2_Silent_p.V541V|RAD54L_uc001cpm.1_Silent_p.V324V	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	541	Helicase C-terminal.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		ACTTATACGTCCGCCTGGATG	0.423								Direct_reversal_of_damage|Homologous_recombination					12	15					0	0	0	0	T	46739822	T	T	46739822	2	4	81	1	0	0	0	0	0	0	0	1	13058	842	30	2		2	RAD54L	1	46739822	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	444595	46739822	202510799	3	16070											
CYP4Z1	199974	broad.mit.edu	37	chr1	47583599	47583599	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatgtgtttgcaaaaaaagTttgctaattttaagtccttt	12	17	6	6	0	0	0	0	0	0	0	1	0	1	0	2	0	2	4	2	0	5	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:47583599T>C	uc001cqu.1	+	12	1514	c.1511T>C	c.(1510-1512)GTT>GCT	p.V504A		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	504	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						GCAAAAAAAGTTTGCTAATTT	0.378													13	12					0	0	0	0	C	47583599	C	C	47583599	3	2	81	1	0	0	0	0	1	0	0	0	4211	1725	60	5	1557	5	CYP4Z1	1	47583599	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	843777	47583599	201667022	4	16071											
C1orf173	127254	broad.mit.edu	37	chr1	75072415	75072415	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgagctgaaaatttggcTgaaacagaggttttgttctc	10	15	10	6	0	2	4	0	3	2	1	3	4	2	4	0	2	2	4	0	2	3	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:75072415T>A	uc001dgg.2	-	10	1578	c.1359A>T	c.(1357-1359)TCA>TCT	p.S453S	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.S247S	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	453	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						AAAATTTGGCTGAAACAGAGG	0.413													93	48					0	0	0	0	A	75072415	A	A	75072415	2	1	81	1	0	0	0	0	0	0	0	1	2023	1567	55	5		5	C1orf173	1	75072415	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	27488816	75072415	174178206	5	16072											
CLCA4	22802	broad.mit.edu	37	chr1	87043754	87043754	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ataccaggctgggtagtgaaCggtgagtaactcatgatatt	12	11	12	6	1	1	3	1	3	0	0	1	3	1	3	1	3	3	3	1	3	5	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:87043754C>T	uc009wcs.2	+	12	2165	c.2121C>T	c.(2119-2121)AAC>AAT	p.N707N	CLCA4_uc009wct.2_Silent_p.N470N|CLCA4_uc009wcu.2_Silent_p.N527N	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	707						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GGGTAGTGAACGGTGAGTAAC	0.388													3	7					0	0	0	0	T	87043754	T	T	87043754	2	4	81	1	0	0	0	0	0	0	0	1	3474	550	19	1		1	CLCA4	1	87043754	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	11971339	87043754	162206867	6	16073											
DPYD	1806	broad.mit.edu	37	chr1	98164954	98164954	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcaaatatagtgatgtcagaGtaccccaatcgagccaaaaa	17	8	7	9	1	2	2	2	1	0	1	3	3	2	2	3	0	2	1	3	0	7	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:98164954G>A	uc001drv.2	-	6	770	c.633C>T	c.(631-633)TAC>TAT	p.Y211Y	DPYD_uc010oub.1_RNA	NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	211					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TGATGTCAGAGTACCCCAATC	0.383													72	40					0	0	0	0	A	98164954	A	A	98164954	2	1	81	1	0	0	0	0	0	0	0	1	4767	1024	36	4		4	DPYD	1	98164954	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	11121200	98164954	151085667	7	16074											
S1PR1	1901	broad.mit.edu	37	chr1	101705292	101705292	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagccgcagctctgagaagtCgctggcgctgctcaagaccg	8	6	13	14	4	2	2	1	1	1	2	3	3	2	2	2	1	3	5	2	1	2	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:101705292C>T	uc001dud.2	+	2	1266	c.752C>T	c.(751-753)TCG>TTG	p.S251L	S1PR1_uc009weg.2_Missense_Mutation_p.S251L	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	251	Cytoplasmic (By similarity).			KSL -> NV (in Ref. 1; AAA52336 and 2; AAC51905).	cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						TCTGAGAAGTCGCTGGCGCTG	0.582													51	49					0	0	0	0	T	101705292	T	T	101705292	3	4	81	1	0	0	0	0	1	0	0	0	13858	893	31	1	754	1	S1PR1	1	101705292	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	3540338	101705292	147545329	8	16075											
HRNR	388697	broad.mit.edu	37	chr1	152187703	152187703	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgatctagagccgtgttgTccgtagccagaggagtgacc	8	9	13	11	2	1	4	0	2	1	2	2	5	2	5	5	1	2	2	5	1	2	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:152187703T>C	uc001ezt.1	-	3	6478	c.6402A>G	c.(6400-6402)GGA>GGG	p.G2134G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2134					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCCGTGTTGTCCGTAGCCAG	0.567													25	626					0	0	0	0	C	152187703	C	C	152187703	2	2	81	1	0	0	0	0	0	0	0	1	7398	1654	58	5		5	HRNR	1	152187703	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	50482411	152187703	97062918	9	16076											
KIAA0907	22889	broad.mit.edu	37	chr1	155887376	155887387	+	In_Frame_Del	DEL	GGGGCTGGGGCT	-	-																															ctggggctgacttgggagtgGgggctggggctggggctggg																										TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:155887376_155887387delGGGGCTGGGGCT	uc001fmi.1	-	11	1367_1378	c.1343_1354delAGCCCCAGCCCC	c.(1342-1356)CAGCCCCAGCCCCCA>CCA	p.QPQP448del	KIAA0907_uc001fmj.1_In_Frame_Del_p.QPQP448del|KIAA0907_uc009wrk.1_In_Frame_Del_p.QPQP305del|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	448_451	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			CTTGGGAGTGggggctggggctggggctgggg	0.439													---	---	---								-	155887387	-	-	155887376	7	5	81	1	0	1	0	1	0	0	0	0	8238	1232	43	0	506	0	KIAA0907	1	155887376	In_Frame_Del	DEL	GGGGCTGGGGCT	TCGA-CN-6024-01A-11D-1683-08	3699673	155887376	93363245	10	16077											
KIRREL	55243	broad.mit.edu	37	chr1	158064599	158064599	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagctcaacacctatagcCggggccctgcctctgactat	8	8	8	17	1	2	1	1	1	1	0	2	1	2	1	5	2	4	1	5	2	4	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:158064599C>T	uc001frn.3	+	15	2367	c.1963C>T	c.(1963-1965)CGG>TGG	p.R655W	KIRREL_uc010pib.1_Missense_Mutation_p.R555W|KIRREL_uc009wsq.2_Missense_Mutation_p.R491W|KIRREL_uc001fro.3_Missense_Mutation_p.R469W|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	655	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CACCTATAGCCGGGGCCCTGC	0.657													13	29					0	0	0	0	T	158064599	T	T	158064599	3	4	81	1	0	0	0	0	1	0	0	0	8363	643	23	1	2021	1	KIRREL	1	158064599	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	2177223	158064599	91186022	11	16078											
ALDH9A1	223	broad.mit.edu	37	chr1	165667675	165667675	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccggctccacgcgggcccCgccgcggtaattgagcggct	4	5	15	17	8	0	1	0	1	0	0	1	1	1	1	5	4	1	3	5	4	1	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:165667675C>T	uc001gdh.1	-	1	226	c.121G>A	c.(121-123)GGG>AGG	p.G41R	uc001gdi.2_5'Flank|ALDH9A1_uc010pky.1_5'UTR|ALDH9A1_uc010pkz.1_Missense_Mutation_p.G41R|ALDH9A1_uc010pla.1_5'UTR	NM_000696	NP_000687	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9A1	17					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	ACGCGGGCCCCGCCGCGGTAA	0.706													14	24					0	0	0	0	T	165667675	T	T	165667675	3	4	81	1	0	0	0	0	1	0	0	0	506	652	23	1	1479	1	ALDH9A1	1	165667675	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	7603076	165667675	83582946	12	16079											
FMO3	2328	broad.mit.edu	37	chr1	171085379	171085379	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgccttctatggaagacatGatgaatgatattaatgagaa	15	13	9	4	0	1	5	0	4	1	2	1	7	1	6	1	1	1	0	1	1	6	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:171085379G>A	uc001ghi.2	+	8	1326	c.1215G>A	c.(1213-1215)ATG>ATA	p.M405I	FMO3_uc001ghh.2_Missense_Mutation_p.M405I|FMO3_uc010pmb.1_Missense_Mutation_p.M385I|FMO3_uc010pmc.1_Missense_Mutation_p.M342I	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	405				PSMEDM -> GPFYGKTL (in Ref. 1; AAA86284).	xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGAAGACATGATGAATGATA	0.358													31	53					0	0	0	0	A	171085379	A	A	171085379	3	1	81	1	0	0	0	0	1	0	0	0	5988	1290	45	2	1241	2	FMO3	1	171085379	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	5417704	171085379	78165242	13	16080											
PAPPA2	60676	broad.mit.edu	37	chr1	176760576	176760576	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcccaccacccccctcagagCtgaattctgtggagtacaaa	11	7	8	15	0	2	2	1	1	1	1	2	3	2	3	5	1	2	2	5	1	3	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:176760576C>A	uc001gkz.2	+	19	6142	c.4978C>A	c.(4978-4980)CTG>ATG	p.L1660M	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1660	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCCCTCAGAGCTGAATTCTGT	0.438													25	27					1.42536e-11	1.63203e-11	1	0	A	176760576	A	A	176760576	3	1	81	1	0	0	0	0	1	0	0	0	11487	796	28	4	5101	4	PAPPA2	1	176760576	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	5675197	176760576	72490045	14	16081											
USH2A	7399	broad.mit.edu	37	chr1	215848787	215848787	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtaggagccagctgagagtCtggaggggcttcatctgtcc	8	9	15	9	0	3	1	1	1	2	1	4	4	4	3	2	4	2	3	2	4	1	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:215848787C>T	uc001hku.1	-	63	12853	c.12466G>A	c.(12466-12468)GAC>AAC	p.D4156N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4156	Extracellular (Potential).|Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGCTGAGAGTCTGGAGGGGCT	0.542										HNSCC(13;0.011)			3	62					0	0	0	0	T	215848787	T	T	215848787	3	4	81	1	0	0	0	0	1	0	0	0	17104	913	32	2	3182	2	USH2A	1	215848787	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	39088211	215848787	33401834	15	16082											
AKT3	10000	broad.mit.edu	37	chr1	243778440	243778440	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctttaatactctgctttcAgttagagtgtgtgccacttc	7	18	7	9	0	3	1	1	0	2	1	4	1	3	1	1	0	3	2	1	0	3	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:243778440A>C	uc001iab.1	-	6	666	c.585T>G	c.(583-585)ACT>ACG	p.T195T	AKT3_uc001hzz.1_Silent_p.T195T	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	195	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			CTCTGCTTTCAGTTAGAGTGT	0.294													19	43					0	0	0	0	C	243778440	C	C	243778440	2	2	81	1	0	0	0	0	0	0	0	1	481	175	7	5		5	AKT3	1	243778440	Silent	SNP	A	TCGA-CN-6024-01A-11D-1683-08	27929653	243778440	5472181	16	16083											
AHCTF1	25909	broad.mit.edu	37	chr1	247051786	247051786	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctaactgagaaaccagtccAtcaatcatcaagcaatcggg	15	7	7	12	1	3	1	3	1	0	1	5	2	4	1	3	1	3	1	3	1	5	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:247051786A>G	uc001ibu.1	-	17	2185	c.2178T>C	c.(2176-2178)GAT>GAC	p.D726D	AHCTF1_uc001ibv.1_Silent_p.D735D|AHCTF1_uc009xgs.1_5'UTR	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	726	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			AAACCAGTCCATCAATCATCA	0.408													32	26					0	0	0	0	G	247051786	G	G	247051786	2	3	81	1	0	0	0	0	0	0	0	1	408	214	8	5		5	AHCTF1	1	247051786	Silent	SNP	A	TCGA-CN-6024-01A-11D-1683-08	3273346	247051786	2198835	17	16084											
ITSN2	50618	broad.mit.edu	37	chr2	24521568	24521568	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagatgaagattcttctttTtagagtttaacctgacaatt	13	16	6	6	0	2	5	0	2	2	3	2	5	2	5	1	0	1	1	1	0	5	8			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:24521568T>C	uc002rfe.2	-	13	1718	c.1460A>G	c.(1459-1461)AAA>AGA	p.K487R	ITSN2_uc002rff.2_Missense_Mutation_p.K487R|ITSN2_uc002rfg.2_Missense_Mutation_p.K487R|ITSN2_uc010eyd.2_Missense_Mutation_p.K512R	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	487	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATTCTTCTTTTTAGAGTTTAA	0.373													30	74					0	0	0	0	C	24521568	C	C	24521568	3	2	81	1	0	0	0	0	1	0	0	0	7966	1841	64	5	3796	5	ITSN2	2	24521568	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08		24521568	218677805	18	16085											
EMILIN1	11117	broad.mit.edu	37	chr2	27303763	27303763	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccctggcccagcctgccCgccccaacctctctggctcc	3	6	9	23	1	1	0	0	0	1	0	3	0	2	0	9	3	3	1	9	3	1	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:27303763C>T	uc002rii.3	+	3	882	c.454C>T	c.(454-456)CGC>TGC	p.R152C	EMILIN1_uc010eyq.1_Missense_Mutation_p.R152C|EMILIN1_uc002rik.3_5'Flank	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	152					cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAGCCTGCCCGCCCCAACCT	0.667											OREG0014513	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	10					0	0	0	0	T	27303763	T	T	27303763	3	4	81	1	0	0	0	0	1	0	0	0	5117	652	23	1	464	1	EMILIN1	2	27303763	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	2782195	27303763	215895610	19	16086											
IFT172	26160	broad.mit.edu	37	chr2	27706461	27706461	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcactttgttgtcagggaCaccacgtaagactctgtccc	9	11	8	13	1	3	1	2	0	1	1	4	2	4	2	2	1	0	2	2	1	1	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:27706461C>T	uc002rku.2	-	6	519	c.468G>A	c.(466-468)GTG>GTA	p.V156V	IFT172_uc002rkw.2_Silent_p.V156V|IFT172_uc010yls.1_Silent_p.V135V|IFT172_uc010ezc.2_Silent_p.V156V|IFT172_uc002rkv.2_Silent_p.V156V	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	156	WD 4.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TTGTCAGGGACACCACGTAAG	0.403													13	41					0	0	0	0	T	27706461	T	T	27706461	2	4	81	1	0	0	0	0	0	0	0	1	7596	465	17	4		4	IFT172	2	27706461	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	402698	27706461	215492912	20	16087											
TRMT61B	55006	broad.mit.edu	37	chr2	29092865	29092865	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggggatgactcttcccgCagcgtcggcagtctgaggtt	6	9	15	11	4	2	2	0	2	2	0	4	4	3	3	1	4	1	3	1	4	0	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:29092865C>T	uc002rmm.2	-	1	311	c.279G>A	c.(277-279)CTG>CTA	p.L93L	TRMT61B_uc002rmn.2_Silent_p.L93L|TRMT61B_uc010ezk.2_RNA	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	93							tRNA (adenine-N1-)-methyltransferase activity				0						ACTCTTCCCGCAGCGTCGGCA	0.612													15	36					0	0	0	0	T	29092865	T	T	29092865	2	4	81	1	0	0	0	0	0	0	0	1	16637	697	25	4		4	TRMT61B	2	29092865	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	1386404	29092865	214106508	21	16088											
CIAO1	9391	broad.mit.edu	37	chr2	96933414	96933414	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggtcaagtcagtggcttggGccccatctggcaacctcctg	7	9	12	13	0	3	0	2	0	1	0	4	0	4	0	4	4	1	2	4	4	2	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:96933414G>A	uc002svs.2	+	3	545	c.340G>A	c.(340-342)GCC>ACC	p.A114T	TMEM127_uc002svq.2_5'Flank|TMEM127_uc002svr.2_5'Flank	NM_004804	NP_004795	O76071	CIAO1_HUMAN	WD repeat domain 39	114	WD 3.				chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding				0						AGTGGCTTGGGCCCCATCTGG	0.537													4	14					0	0	0	0	A	96933414	A	A	96933414	3	1	81	1	0	0	0	0	1	0	0	0	3433	1203	42	4	350	4	CIAO1	2	96933414	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	67840549	96933414	146265959	22	16089											
SLC9A4	389015	broad.mit.edu	37	chr2	103125363	103125363	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaaaaaccaataaaaaaGaatccatcaatgaagagctt	23	8	4	6	0	1	3	1	1	0	2	2	3	2	3	2	0	2	1	2	0	11	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:103125363G>T	uc002tbz.3	+	6	1916	c.1459G>T	c.(1459-1461)GAA>TAA	p.E487*		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	487	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CAATAAAAAAGAATCCATCAA	0.353													18	57					3.99206e-14	4.66419e-14	1	0	T	103125363	T	T	103125363	4	4	81	1	0	0	0	0	0	1	0	0	14780	943	33	2	1481	2	SLC9A4	2	103125363	Nonsense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	6191949	103125363	140074010	23	16090											
NCK2	8440	broad.mit.edu	37	chr2	106497977	106497977	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggggtcgcgcgtcaccgtCatggagaagtgcagcgacgg	9	5	17	10	6	2	1	2	0	0	1	3	3	2	1	1	4	2	1	1	4	2	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:106497977C>T	uc002tdg.2	+	4	862	c.420C>T	c.(418-420)GTC>GTT	p.V140V	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Silent_p.V140V	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	140	SH3 2.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GCGTCACCGTCATGGAGAAGT	0.632													39	49					0	0	0	0	T	106497977	T	T	106497977	2	4	81	1	0	0	0	0	0	0	0	1	10274	813	29	2		2	NCK2	2	106497977	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	3372614	106497977	136701396	24	16091											
LRP1B	53353	broad.mit.edu	37	chr2	141272305	141272306	+	Missense_Mutation	DNP	GC	AA	AA																															gcttagaaatacatttttgtGcggaacaagcaaattggttc																										TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:141272305_141272306GC>AA	uc002tvj.1	-	51	9157_9158	c.8185_8186GC>TT	c.(8185-8187)GCA>TTA	p.A2729L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2729	Extracellular (Potential).|LDL-receptor class A 16.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACATTTTTGTGCGGAACAAGCA	0.342										TSP Lung(27;0.18)			11	37					0	0	0	0	AA	141272306	AA	AA	141272305	3	1	81	1	0	0	0	0	1	0	0	0	9005	1319	46	4	5777	4	LRP1B	2	141272305	Missense_Mutation	DNP	GC	TCGA-CN-6024-01A-11D-1683-08	34774328	141272305	101927068	25	16092											
NEB	4703	broad.mit.edu	37	chr2	152398013	152398013	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaagatcaggagtatcaGgaactgaagtaaagattgac	18	9	10	4	0	2	4	2	2	0	2	2	6	2	6	0	2	1	2	0	2	7	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:152398013G>T	uc010fnx.2	-	108	15718	c.15527C>A	c.(15526-15528)CCT>CAT	p.P5176H	NEB_uc002txr.2_Missense_Mutation_p.P1599H	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5176	Nebulin 141.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGGAGTATCAGGAACTGAAGT	0.473													19	81					7.21436e-19	8.74121e-19	1	0	T	152398013	T	T	152398013	3	4	81	1	0	0	0	0	1	0	0	0	10356	1000	35	4	5244	4	NEB	2	152398013	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	11125708	152398013	90801360	26	16093											
RBMS1	5937	broad.mit.edu	37	chr2	161223852	161223852	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctactgttgttattactgctGgtggtgctgggactgggagg	5	14	16	6	0	0	0	0	0	0	0	0	2	0	2	0	5	4	4	0	5	3	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:161223852G>T	uc002ubo.2	-	2	570	c.126C>A	c.(124-126)ACC>ACA	p.T42T	RBMS1_uc002ubj.2_Silent_p.T9T|RBMS1_uc002ubk.2_Silent_p.T9T|RBMS1_uc002ubl.2_Silent_p.T40T|RBMS1_uc002ubn.2_Silent_p.T42T|RBMS1_uc002ubi.3_Silent_p.T42T|RBMS1_uc002ubm.2_Silent_p.T9T|RBMS1_uc002ubp.2_Silent_p.T42T|RBMS1_uc010fox.2_Silent_p.T42T	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	42					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0						tattactgctggtggtgctgG	0.448													14	44					1.05317e-09	1.19394e-09	1	0	T	161223852	T	T	161223852	2	4	81	1	0	0	0	0	0	0	0	1	13213	1335	47	4		4	RBMS1	2	161223852	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	8825839	161223852	81975521	27	16094											
TTC21B	79809	broad.mit.edu	37	chr2	166770094	166770094	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaattttacctctagaataTtcatgtatgcatcaccaagg	14	13	6	8	0	3	1	2	0	1	1	3	2	3	1	2	1	2	2	2	1	7	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:166770094T>C	uc002udk.2	-	16	2334	c.2201A>G	c.(2200-2202)AAT>AGT	p.N734S		NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	734	TPR 9.					cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						CTCTAGAATATTCATGTATGC	0.313													16	51					0	0	0	0	C	166770094	C	C	166770094	3	2	81	1	0	0	0	0	1	0	0	0	16756	1493	52	5	1805	5	TTC21B	2	166770094	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	5546242	166770094	76429279	28	16095											
TTN	7273	broad.mit.edu	37	chr2	179587395	179587395	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatcatcaccttgaattcTgaacacagtcttagaagaag	16	11	6	8	0	4	4	2	2	2	2	4	4	4	4	1	0	1	0	1	0	7	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:179587395T>C	uc010zfg.1	-	73	18723	c.18499A>G	c.(18499-18501)AGA>GGA	p.R6167G	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R2828G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7094							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTGAATTCTGAACACAGTC	0.323													4	21					0	0	0	0	C	179587395	C	C	179587395	3	2	81	1	0	0	0	0	1	0	0	0	16803	1588	55	5	82446	5	TTN	2	179587395	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	12817301	179587395	63611978	29	16096											
CCDC141	285025	broad.mit.edu	37	chr2	179736188	179736188	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcatgtcattccatttttgtCgtagatctaaaatgaactgg	11	16	7	7	1	3	2	2	1	1	1	5	2	4	2	1	1	1	1	1	1	4	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:179736188C>T	uc002unf.1	-	4	503	c.446G>A	c.(445-447)CGA>CAA	p.R149Q		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	149							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCATTTTTGTCGTAGATCTAA	0.393													33	162					0	0	0	0	T	179736188	T	T	179736188	3	4	81	1	0	0	0	0	1	0	0	0	2787	884	31	1	2221	1	CCDC141	2	179736188	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	148793	179736188	63463185	30	16097											
SESTD1	91404	broad.mit.edu	37	chr2	180036936	180036936	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggctttaccacacaaacaaGggacacctcagctggaacaa	15	6	8	12	0	1	0	1	0	0	0	1	2	1	2	2	3	4	2	2	3	5	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:180036936G>A	uc002uni.3	-	5	430	c.280C>T	c.(280-282)CTT>TTT	p.L94F		NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	94	CRAL-TRIO.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			ACACAAACAAGGGACACCTCA	0.308													20	58					0	0	0	0	A	180036936	A	A	180036936	3	1	81	1	0	0	0	0	1	0	0	0	14192	1000	35	4	1866	4	SESTD1	2	180036936	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	300748	180036936	63162437	31	16098											
ERBB4	2066	broad.mit.edu	37	chr2	212251875	212251875	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcggtatacaaactggtTctgttaataagagaaacata	16	12	7	6	1	2	1	0	0	2	1	3	2	2	1	0	2	3	3	0	2	7	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:212251875T>G	uc002veg.1	-	27	3282	c.3184A>C	c.(3184-3186)AAC>CAC	p.N1062H	ERBB4_uc002veh.1_Missense_Mutation_p.N1046H|ERBB4_uc010zji.1_Missense_Mutation_p.N1052H|ERBB4_uc010zjj.1_Missense_Mutation_p.N1036H	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1062	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ACAAACTGGTTCTGTTAATAA	0.423										TSP Lung(8;0.080)			31	70					0	0	0	0	G	212251875	G	G	212251875	3	3	81	1	0	0	0	0	1	0	0	0	5233	1797	62	5	750	5	ERBB4	2	212251875	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	32214939	212251875	30947498	32	16099											
MRPS25	64432	broad.mit.edu	37	chr3	15100956	15100956	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagggtttttgtattgaatcTgaggtatgttgaaaaacaca	14	14	10	3	0	1	3	0	3	1	0	1	3	1	3	0	2	1	4	0	2	6	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:15100956T>A	uc003bzl.2	-	2	276	c.161A>T	c.(160-162)CAG>CTG	p.Q54L	MRPS25_uc011avl.1_Missense_Mutation_p.Q54L|MRPS25_uc011avm.1_Missense_Mutation_p.Q54L	NM_022497	NP_071942	P82663	RT25_HUMAN	mitochondrial ribosomal protein S25	54					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						GTATTGAATCTGAGGTATGTT	0.383													5	11					0	0	0	0	A	15100956	A	A	15100956	3	1	81	1	0	0	0	0	1	0	0	0	9889	1580	55	5	372	5	MRPS25	3	15100956	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08		15100956	182921474	33	16100											
PTPN23	25930	broad.mit.edu	37	chr3	47450995	47450995	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaggaccgtgtcctctgtgCactgacagaggccaacgtgc	8	7	12	14	2	1	2	0	1	1	1	2	3	2	3	4	2	3	1	4	2	1	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:47450995C>T	uc003crf.1	+	18	1982	c.1886C>T	c.(1885-1887)GCA>GTA	p.A629V	PTPN23_uc011baw.1_Missense_Mutation_p.A594V|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Missense_Mutation_p.A499V	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	629					cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTCCTCTGTGCACTGACAGAG	0.597													20	3					0	0	0	0	T	47450995	T	T	47450995	3	4	81	1	0	0	0	0	1	0	0	0	12853	710	25	4	1956	4	PTPN23	3	47450995	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	32350039	47450995	150571435	34	16101											
FAM19A4	151647	broad.mit.edu	37	chr3	68802098	68802098	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccgtttgtgaccgctcttCtatgcggttcttattgcagc	5	15	10	11	3	3	1	0	1	3	0	3	2	3	1	2	1	3	4	2	1	2	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:68802098C>T	uc003dnh.1	-	4	645	c.202G>A	c.(202-204)GAA>AAA	p.E68K	FAM19A4_uc003dni.1_Missense_Mutation_p.E68K	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine	68						extracellular region				skin(2)	2		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		GACCGCTCTTCTATGCGGTTC	0.537													21	25					0	0	0	0	T	68802098	T	T	68802098	3	4	81	1	0	0	0	0	1	0	0	0	5562	922	32	2	232	2	FAM19A4	3	68802098	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	21351103	68802098	129220332	35	16102											
ARL6	84100	broad.mit.edu	37	chr3	97503853	97503853	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgatagattaagaatggtTgtggccaaagaagaactcga	16	9	12	4	1	0	5	0	1	0	4	1	6	0	5	1	2	1	1	1	2	6	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:97503853T>A	uc003drv.2	+	6	622	c.309T>A	c.(307-309)GTT>GTA	p.V103V	ARL6_uc003drw.2_RNA|ARL6_uc003dru.2_Silent_p.V103V|ARL6_uc010hoy.2_Silent_p.V103V	NM_177976	NP_816931	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	103					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		TAAGAATGGTTGTGGCCAAAG	0.323									Bardet-Biedl_syndrome				28	24					0	0	0	0	A	97503853	A	A	97503853	2	1	81	1	0	0	0	0	0	0	0	1	943	1799	63	5		5	ARL6	3	97503853	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	28701755	97503853	100518577	36	16103											
FAM55C	91775	broad.mit.edu	37	chr3	101535759	101535759	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taatgaccctgacaacattaCagagtgcttacaaagaaaag	18	8	7	8	0	0	4	0	2	0	2	0	4	0	4	1	0	4	1	1	0	7	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:101535759C>G	uc003dvn.2	+	7	1680	c.1043C>G	c.(1042-1044)ACA>AGA	p.T348R	FAM55C_uc010hpn.2_Missense_Mutation_p.T348R	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	348						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						GACAACATTACAGAGTGCTTA	0.408													29	113					0	0	0	0	G	101535759	G	G	101535759	3	3	81	1	0	0	0	0	1	0	0	0	5618	478	17	4	1057	4	FAM55C	3	101535759	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	4031906	101535759	96486671	37	16104											
UROC1	131669	broad.mit.edu	37	chr3	126219567	126219567	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaggtccttgaacacagcAgggttggaggccatgaggct	10	7	14	10	0	0	2	0	2	0	0	1	3	1	3	3	5	2	3	3	5	1	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:126219567A>T	uc003eiz.1	-	11	1148	c.1116T>A	c.(1114-1116)CCT>CCA	p.P372P	UROC1_uc010hsi.1_Silent_p.P432P	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	372					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		TGAACACAGCAGGGTTGGAGG	0.597													29	113					0	0	0	0	T	126219567	T	T	126219567	2	4	81	1	0	0	0	0	0	0	0	1	17096	175	7	5		5	UROC1	3	126219567	Silent	SNP	A	TCGA-CN-6024-01A-11D-1683-08	24683808	126219567	71802863	38	16105											
COL6A6	131873	broad.mit.edu	37	chr3	130293063	130293063	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggaaacacacacatcggtGctgcactcagggaggtggaa	12	7	13	9	1	1	0	1	0	0	0	2	3	1	3	0	5	3	2	0	5	2	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:130293063G>T	uc010htl.2	+	7	3272	c.3241G>T	c.(3241-3243)GCT>TCT	p.A1081S		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1081	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						ACACATCGGTGCTGCACTCAG	0.478													12	60					9.31168e-06	9.8721e-06	1	0	T	130293063	T	T	130293063	3	4	81	1	0	0	0	0	1	0	0	0	3718	1319	46	4	3267	4	COL6A6	3	130293063	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	4073496	130293063	67729367	39	16106											
SIAH2	6478	broad.mit.edu	37	chr3	150460290	150460290	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttaatgtctgtagctagaaAgacgatgtcttctccctgaa	11	13	9	8	1	3	3	0	1	3	2	4	4	3	3	1	0	1	3	1	0	5	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:150460290A>T	uc003eyi.2	-	2	1240	c.613T>A	c.(613-615)TTT>ATT	p.F205I		NM_005067	NP_005058	O43255	SIAH2_HUMAN	seven in absentia homolog 2	205	SBD.				apoptosis|axon guidance|cell cycle|negative regulation of canonical Wnt receptor signaling pathway|small GTPase mediated signal transduction|ubiquitin-dependent protein catabolic process	cytosol|nucleus	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GTAGCTAGAAAGACGATGTCT	0.522													15	61					0	0	0	0	T	150460290	T	T	150460290	3	4	81	1	0	0	0	0	1	0	0	0	14365	72	3	5	365	5	SIAH2	3	150460290	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	20167227	150460290	47562140	40	16107											
PPM1L	151742	broad.mit.edu	37	chr3	160474321	160474321	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgatcgactcggggggctTgatgtgctcgaggccgagtt	7	9	16	9	5	0	1	0	1	0	0	3	5	0	1	1	4	2	3	1	4	1	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:160474321T>C	uc003fdr.2	+	1	326	c.225T>C	c.(223-225)CTT>CTC	p.L75L		NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	75	Cytoplasmic (Potential).				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			TCGGGGGGCTTGATGTGCTCG	0.597													3	32					0	0	0	0	C	160474321	C	C	160474321	2	2	81	1	0	0	0	0	0	0	0	1	12404	1799	63	5		5	PPM1L	3	160474321	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	10014031	160474321	37548109	41	16108											
SLITRK3	22865	broad.mit.edu	37	chr3	164907251	164907251	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaagaggctctttaagttGggcaagttgataaaggcccc	12	9	13	7	0	1	2	0	1	1	1	1	3	1	3	2	4	0	4	2	4	5	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:164907251G>T	uc003fej.3	-	2	1812	c.1368C>A	c.(1366-1368)CCC>CCA	p.P456P	SLITRK3_uc003fek.2_Silent_p.P456P	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	456	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TCTTTAAGTTGGGCAAGTTGA	0.428										HNSCC(40;0.11)			9	35					3.09899e-07	3.36335e-07	1	0	T	164907251	T	T	164907251	2	4	81	1	0	0	0	0	0	0	0	1	14808	1335	47	4		4	SLITRK3	3	164907251	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	4432930	164907251	33115179	42	16109											
PLD1	5337	broad.mit.edu	37	chr3	171394568	171394568	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagccgccttcccgtggacTgcagaggcaatgtcatgcca	8	7	12	14	3	1	1	1	0	0	1	2	3	2	2	4	2	3	2	4	2	1	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:171394568T>G	uc003fhs.2	-	18	2168	c.2052A>C	c.(2050-2052)GCA>GCC	p.A684A	PLD1_uc003fht.2_Silent_p.A646A|PLD1_uc003fhu.3_5'Flank|PLD1_uc003fhv.1_Silent_p.A9A	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	684	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TCCCGTGGACTGCAGAGGCAA	0.517													8	33					0	0	0	0	G	171394568	G	G	171394568	2	3	81	1	0	0	0	0	0	0	0	1	12100	1567	55	5		5	PLD1	3	171394568	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	6487317	171394568	26627862	43	16110											
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	17	7	10	7	0	1	2	1	2	0	0	1	4	1	3	0	3	3	2	0	3	5	0	rs121913279		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			26	27					0	0	0	0	G	178952085	G	G	178952085	3	3	81	1	0	0	0	0	1	0	0	0	11968	217	8	5	3218	5	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	7557517	178952085	19070345	44	16111											
PARL	55486	broad.mit.edu	37	chr3	183547407	183547407	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacttagagccacctcctttTttggggccattagtccttat	7	16	7	11	0	0	1	0	0	0	1	2	1	2	1	5	2	2	0	5	2	4	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:183547407T>C	uc003fmd.2	-	10	1178	c.1119A>G	c.(1117-1119)AAA>AAG	p.K373K	PARL_uc003fme.2_Silent_p.K323K	NM_018622	NP_061092	Q9H300	PARL_HUMAN	presenilin associated, rhomboid-like isoform 1	373	Mitochondrial intermembrane (Potential).				proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity				0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CACCTCCTTTTTTGGGGCCAT	0.488													67	182					0	0	0	0	C	183547407	C	C	183547407	2	2	81	1	0	0	0	0	0	0	0	1	11505	1838	64	5		5	PARL	3	183547407	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	4595322	183547407	14475023	45	16112											
CD38	952	broad.mit.edu	37	chr4	15835919	15835919	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtattctggaaaacggtttcCcgcagggtaagtaccaagta	12	10	11	8	2	1	0	0	0	1	0	2	1	2	1	2	3	2	6	2	3	7	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:15835919C>A	uc011bxc.1	+	4	686	c.579C>A	c.(577-579)TCC>TCA	p.S193S	CD38_uc003gol.1_Silent_p.S193S	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	193	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						AAACGGTTTCCCGCAGGGTAA	0.368													9	30					0.000274275	0.000289442	1	0	A	15835919	A	A	15835919	2	1	81	1	0	0	0	0	0	0	0	1	3024	610	22	4		4	CD38	4	15835919	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08		15835919	175318357	46	16113											
GABRG1	2565	broad.mit.edu	37	chr4	46067515	46067515	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atttttccaaccatattactGttaagcataagcactttcat	13	16	3	9	0	1	0	1	0	0	0	2	0	2	0	2	0	4	3	2	0	5	7	rs144076673		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:46067515G>T	uc003gxb.2	-	4	560	c.408C>A	c.(406-408)AAC>AAA	p.N136K		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	136	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CCATATTACTGTTAAGCATAA	0.328													7	36					5.18039e-06	5.5435e-06	1	0	T	46067515	T	T	46067515	3	4	81	1	0	0	0	0	1	0	0	0	6205	1368	48	4	1013	4	GABRG1	4	46067515	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	30231596	46067515	145086761	47	16114											
CORIN	10699	broad.mit.edu	37	chr4	47667085	47667085	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcgcctgtattcacatcaCattttggtaccaaaatggtg	10	13	8	10	1	2	0	2	0	0	0	3	0	2	0	2	2	1	3	2	2	4	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:47667085C>T	uc003gxm.2	-	11	1646	c.1553G>A	c.(1552-1554)TGT>TAT	p.C518Y	CORIN_uc011bzf.1_Missense_Mutation_p.C379Y|CORIN_uc011bzg.1_Missense_Mutation_p.C451Y|CORIN_uc011bzh.1_Missense_Mutation_p.C481Y|CORIN_uc011bzi.1_Missense_Mutation_p.C481Y	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	518	Extracellular (Potential).|FZ 2.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						ATTCACATCACATTTTGGTAC	0.443													17	44					0	0	0	0	T	47667085	T	T	47667085	3	4	81	1	0	0	0	0	1	0	0	0	3767	478	17	4	1623	4	CORIN	4	47667085	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	1599570	47667085	143487191	48	16115											
BDH2	56898	broad.mit.edu	37	chr4	104016422	104016422	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtggctatgactttggcaCcttctcttgcaaaagcctag	8	13	9	11	0	1	1	0	1	1	0	2	1	1	1	2	2	2	3	2	2	4	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:104016422C>A	uc003hwz.2	-	3	194	c.89G>T	c.(88-90)GGT>GTT	p.G30V	BDH2_uc003hxa.2_RNA	NM_020139	NP_064524	Q9BUT1	BDH2_HUMAN	3-hydroxybutyrate dehydrogenase, type 2	30	NAD.				fatty acid beta-oxidation|heme metabolic process|iron ion homeostasis|siderophore biosynthetic process	cytoplasm	3-hydroxybutyrate dehydrogenase activity|NAD binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.02e-08)		GACTTTGGCACCTTCTCTTGC	0.403													24	36					1.64293e-13	1.90981e-13	1	0	A	104016422	A	A	104016422	3	1	81	1	0	0	0	0	1	0	0	0	1393	507	18	4	680	4	BDH2	4	104016422	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	56349337	104016422	87137854	49	16116											
C4orf21	55345	broad.mit.edu	37	chr4	113553143	113553143	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgccacacttttgacttcttCatcttttgatgagtatatag	9	18	6	8	0	3	3	1	3	2	0	3	3	3	3	1	0	1	1	1	0	3	9			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:113553143C>T	uc003iau.2	-	3	256	c.45G>A	c.(43-45)ATG>ATA	p.M15I	C4orf21_uc003iaw.2_Missense_Mutation_p.M15I	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TTGACTTCTTCATCTTTTGAT	0.308													26	10					0	0	0	0	T	113553143	T	T	113553143	3	4	81	1	0	0	0	0	1	0	0	0	2264	826	29	2	6373	2	C4orf21	4	113553143	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	9536721	113553143	77601133	50	16117											
PCDH10	57575	broad.mit.edu	37	chr4	134084195	134084195	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggccactcagatcggtgctGgatgccttcttttgtccctt	4	14	11	12	1	2	1	1	0	1	1	4	2	3	2	3	3	2	1	3	3	0	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:134084195G>A	uc003iha.2	+	4	3687	c.2861G>A	c.(2860-2862)TGG>TAG	p.W954*		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	954	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GATCGGTGCTGGATGCCTTCT	0.488													34	26					0	0	0	0	A	134084195	A	A	134084195	4	1	81	1	0	0	0	0	0	1	0	0	11561	1357	47	4	2935	4	PCDH10	4	134084195	Nonsense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	20531052	134084195	57070081	51	16118											
FAT1	2195	broad.mit.edu	37	chr4	187532702	187532705	+	Frame_Shift_Del	DEL	CAAA	-	-																															ggcaccatattcacggtactCaaacacaggggggttgtcat																										TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:187532702_187532705delCAAA	uc003izf.2	-	14	9876_9879	c.9688_9691delTTTG	c.(9688-9693)TTTGAGfs	p.F3230fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3230_3231	Extracellular (Potential).|Cadherin 30.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TCACGGTACTCAAACACAGGGGGG	0.471										HNSCC(5;0.00058)			---	---	---								-	187532705	-	-	187532702	7	5	81	1	0	1	0	1	0	0	0	0	5721	835	29	0	4131	0	FAT1	4	187532702	Frame_Shift_Del	DEL	CAAA	TCGA-CN-6024-01A-11D-1683-08	53448507	187532702	3621574	52	16119											
SLC6A3	6531	broad.mit.edu	37	chr5	1432743	1432743	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggagaagagatagtgcagCgcccaggcgatgatgacgtt	12	6	16	7	3	0	4	0	2	0	2	0	8	0	4	1	2	2	2	1	2	2	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:1432743C>A	uc003jck.2	-	4	610	c.489G>T	c.(487-489)GCG>GCT	p.A163A		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	163	Extracellular (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	GATAGTGCAGCGCCCAGGCGA	0.587													8	22					5.18039e-06	5.5435e-06	1	0	A	1432743	A	A	1432743	2	1	81	1	0	0	0	0	0	0	0	1	14749	755	27	3		3	SLC6A3	5	1432743	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08		1432743	179482517	53	16120											
CTNND2	1501	broad.mit.edu	37	chr5	11565110	11565110	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgcatcgctccagctggCtggctacgatctgccgttca	5	11	11	14	3	2	0	1	0	1	0	4	1	3	0	2	2	4	7	2	2	1	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:11565110C>T	uc003jfa.1	-	3	378	c.233G>A	c.(232-234)AGC>AAC	p.S78N	CTNND2_uc010itt.2_5'UTR|CTNND2_uc011cmy.1_5'UTR|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	78	Potential.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CTCCAGCTGGCTGGCTACGAT	0.517													16	15					0	0	0	0	T	11565110	T	T	11565110	3	4	81	1	0	0	0	0	1	0	0	0	4037	797	28	4	3524	4	CTNND2	5	11565110	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	10132367	11565110	169350150	54	16121											
MYO10	4651	broad.mit.edu	37	chr5	16877787	16877787	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acagtacttggaaaatgctgGccattttctctcagccagac	11	11	8	11	0	2	1	1	0	1	1	3	2	2	2	2	2	3	2	2	2	3	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:16877787G>T	uc003jft.3	-	2	519	c.51C>A	c.(49-51)GGC>GGA	p.G17G	MYO10_uc003jfu.2_Intron|MYO10_uc003jfv.2_Silent_p.G17G	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	17	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						GAAAATGCTGGCCATTTTCTC	0.458													12	20					2.80697e-09	3.1356e-09	1	0	T	16877787	T	T	16877787	2	4	81	1	0	0	0	0	0	0	0	1	10115	1190	42	4		4	MYO10	5	16877787	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	5312677	16877787	164037473	55	16122											
PRDM9	56979	broad.mit.edu	37	chr5	23526849	23526850	+	Missense_Mutation	DNP	TC	AT	AT																															gacacatacaggggagaagcTctacgtctgcagggagtgtg																										TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:23526849_23526850TC>AT	uc003jgo.2	+	11	1834_1835	c.1652_1653TC>AT	c.(1651-1653)CTC>CAT	p.L551H		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	551					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGGGAGAAGCTCTACGTCTGCA	0.485										HNSCC(3;0.000094)			32	58					0	0	0	0	AT	23526850	AT	AT	23526849	3	1	81	1	0	0	0	0	1	0	0	0	12525	1551	54	5	1690	5	PRDM9	5	23526849	Missense_Mutation	DNP	TC	TCGA-CN-6024-01A-11D-1683-08	6649062	23526849	157388411	56	16123											
CDH6	1004	broad.mit.edu	37	chr5	31294222	31294222	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacccgtttacatccttcgaGctcaagctataaacagaagg	14	9	7	11	2	1	1	1	0	0	1	3	2	2	1	2	1	5	3	2	1	7	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:31294222G>T	uc003jhe.1	+	3	708	c.382G>T	c.(382-384)GCT>TCT	p.A128S	CDH6_uc003jhd.1_Missense_Mutation_p.A128S	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	128	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CATCCTTCGAGCTCAAGCTAT	0.453													24	117					3.7963e-18	4.55159e-18	1	0	T	31294222	T	T	31294222	3	4	81	1	0	0	0	0	1	0	0	0	3129	971	34	4	388	4	CDH6	5	31294222	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	7767373	31294222	149621038	57	16124											
RXFP3	51289	broad.mit.edu	37	chr5	33937766	33937766	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggaccaaaggaggggccgcGgtagccggaggacgcccgac	9	1	19	12	5	0	0	0	0	0	0	0	5	0	4	4	7	1	1	4	7	2	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:33937766G>A	uc003jic.1	+	1	1278	c.921G>A	c.(919-921)GCG>GCA	p.A307A		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	307	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GAGGGGCCGCGGTAGCCGGAG	0.652													6	7					0	0	0	0	A	33937766	A	A	33937766	2	1	81	1	0	0	0	0	0	0	0	1	13826	1103	39	1		1	RXFP3	5	33937766	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	2643544	33937766	146977494	58	16125											
WDR70	55100	broad.mit.edu	37	chr5	37605263	37605263	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtcattcccactacgtgcAcatatagtagagatggaaac	15	9	8	9	1	1	1	1	0	0	1	2	3	2	2	1	1	3	2	1	1	6	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:37605263A>T	uc003jkv.2	+	10	1073	c.1015A>T	c.(1015-1017)ACA>TCA	p.T339S	WDR70_uc010iva.1_Missense_Mutation_p.T339S	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	339	WD 4.									ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CACTACGTGCACATATAGTAG	0.418													21	54					0	0	0	0	T	37605263	T	T	37605263	3	4	81	1	0	0	0	0	1	0	0	0	17389	159	6	5	1053	5	WDR70	5	37605263	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	3667497	37605263	143309997	59	16126											
COL4A3BP	10087	broad.mit.edu	37	chr5	74722212	74722212	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acaccttgaatgaagaggtgGatgttgcagagtagccactt	12	10	12	7	0	0	4	0	2	0	2	0	5	0	5	2	2	2	3	2	2	3	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:74722212G>C	uc011csu.1	-	4	862	c.440C>G	c.(439-441)TCC>TGC	p.S147C	COL4A3BP_uc003kds.2_Missense_Mutation_p.S147C|COL4A3BP_uc003kdt.2_Missense_Mutation_p.S275C|COL4A3BP_uc003kdu.2_Missense_Mutation_p.S147C	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	147					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		TGAAGAGGTGGATGTTGCAGA	0.398													9	31					0	0	0	0	C	74722212	C	C	74722212	3	2	81	1	0	0	0	0	1	0	0	0	3707	1174	41	2	1490	2	COL4A3BP	5	74722212	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	37116949	74722212	106193048	60	16127											
IQGAP2	10788	broad.mit.edu	37	chr5	75886317	75886317	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacactaagaaacccaaatgCggttttaactttagtggatg	15	11	8	7	1	0	1	0	0	0	1	0	2	0	2	1	2	4	1	1	2	6	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:75886317C>T	uc003kek.2	+	8	947	c.725C>T	c.(724-726)GCG>GTG	p.A242V		NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	242					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AACCCAAATGCGGTTTTAACT	0.378													28	25					0	0	0	0	T	75886317	T	T	75886317	3	4	81	1	0	0	0	0	1	0	0	0	7854	768	27	1	755	1	IQGAP2	5	75886317	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	1164105	75886317	105028943	61	16128											
PCDHA7	56141	broad.mit.edu	37	chr5	140215095	140215095	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacattgattagcgtgtttgAccgagattttggagtcaacg	10	13	11	7	3	1	3	1	2	0	1	1	5	1	4	1	1	2	1	1	1	2	5	rs145294768		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:140215095A>T	uc003lhq.2	+	1	1127	c.1127A>T	c.(1126-1128)GAC>GTC	p.D376V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.D376V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	376	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGTGTTTGACCGAGATTTT	0.502													24	61					0	0	0	0	T	140215095	T	T	140215095	3	4	81	1	0	0	0	0	1	0	0	0	11583	275	10	5	1129	5	PCDHA7	5	140215095	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	64328778	140215095	40700165	62	16129											
PCDHA7	56141	broad.mit.edu	37	chr5	140215144	140215144	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgctccctgacgccccgCgttcccttcaagttggtgtc	4	11	9	17	3	1	1	1	1	0	0	4	1	3	1	5	1	1	3	5	1	1	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:140215144C>T	uc003lhq.2	+	1	1176	c.1176C>T	c.(1174-1176)CGC>CGT	p.R392R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.R392R	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	392	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACGCCCCGCGTTCCCTTCA	0.537													27	88					0	0	0	0	T	140215144	T	T	140215144	2	4	81	1	0	0	0	0	0	0	0	1	11583	755	27	1		1	PCDHA7	5	140215144	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	49	140215144	40700116	63	16130											
PCDHB6	56130	broad.mit.edu	37	chr5	140530019	140530019	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgggggagctggcttcgCggggcgctcgggttgttttc	1	11	21	8	4	0	0	0	0	0	0	3	1	0	1	0	7	1	5	0	7	0	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:140530019C>T	uc003lir.2	+	1	181	c.181C>T	c.(181-183)CGG>TGG	p.R61W	PCDHB6_uc011dah.1_Intron	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	61	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGGCTTCGCGGGGCGCTCG	0.507													24	51					0	0	0	0	T	140530019	T	T	140530019	3	4	81	1	0	0	0	0	1	0	0	0	11600	759	27	1	183	1	PCDHB6	5	140530019	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	314875	140530019	40385241	64	16131											
DIAPH1	1729	broad.mit.edu	37	chr5	140908052	140908052	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccacatgggcaagctcgTctggaaacttgaggacatcg	10	9	11	11	2	2	1	0	1	2	0	5	3	2	3	1	3	2	2	1	3	2	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:140908052T>A	uc003llb.3	-	24	3257	c.3116A>T	c.(3115-3117)GAC>GTC	p.D1039V	DIAPH1_uc011dbd.1_5'Flank|DIAPH1_uc003llc.3_Missense_Mutation_p.D1030V|DIAPH1_uc010jgc.1_Missense_Mutation_p.D475V	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	1039	Potential.|FH2.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCAAGCTCGTCTGGAAACTT	0.498													22	17					0	0	0	0	A	140908052	A	A	140908052	3	1	81	1	0	0	0	0	1	0	0	0	4540	1667	58	5	726	5	DIAPH1	5	140908052	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	378033	140908052	40007208	65	16132											
PCDH12	51294	broad.mit.edu	37	chr5	141336084	141336084	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actgatctgaatgctgagctGtttcttggctgataagggct	8	14	12	7	0	2	4	0	4	2	0	2	4	2	4	0	2	2	5	0	2	2	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:141336084G>A	uc003llx.2	-	1	2544	c.1333C>T	c.(1333-1335)CAG>TAG	p.Q445*		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	445	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCTGAGCTGTTTCTTGGCT	0.488													32	70					0	0	0	0	A	141336084	A	A	141336084	4	1	81	1	0	0	0	0	0	1	0	0	11564	1386	48	4	2237	4	PCDH12	5	141336084	Nonsense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	428032	141336084	39579176	66	16133											
LARS	51520	broad.mit.edu	37	chr5	145506097	145506097	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttgttgtcaggcagtttTccgttattggcctaagaaaa	10	15	9	7	1	1	1	1	0	0	1	2	1	2	1	2	2	0	4	2	2	4	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:145506097T>A	uc003lnx.1	-	28	3130	c.2892A>T	c.(2890-2892)GGA>GGT	p.G964G	LARS_uc003lnw.1_Silent_p.G122G|LARS_uc011dbq.1_Silent_p.G918G|LARS_uc011dbr.1_Silent_p.G910G|LARS_uc011dbs.1_Silent_p.G937G	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	964					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CAGGCAGTTTTCCGTTATTGG	0.408													31	9					0	0	0	0	A	145506097	A	A	145506097	2	1	81	1	0	0	0	0	0	0	0	1	8674	1770	62	5		5	LARS	5	145506097	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	4170013	145506097	35409163	67	16134											
CCNJL	79616	broad.mit.edu	37	chr5	159686758	159686758	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaacttggggacgtggtCttcccgatcctcgaacttac	7	11	9	14	3	1	0	0	0	1	0	5	3	4	1	3	3	3	0	3	3	3	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:159686758C>A	uc003lyb.1	-	5	697	c.445G>T	c.(445-447)GAC>TAC	p.D149Y	CCNJL_uc011dee.1_Missense_Mutation_p.D101Y|CCNJL_uc003lyc.1_RNA|CCNJL_uc011def.1_Missense_Mutation_p.D101Y	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	149	Cyclin N-terminal.					nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGACGTGGTCTTCCCGATCC	0.557													29	24					1.88708e-17	2.23908e-17	1	0	A	159686758	A	A	159686758	3	1	81	1	0	0	0	0	1	0	0	0	2944	913	32	2	874	2	CCNJL	5	159686758	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	14180661	159686758	21228502	68	16135											
RNF130	55819	broad.mit.edu	37	chr5	179440200	179440200	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgaagttcttcggtggcAttcgagttccaacagctatt	8	13	11	9	2	1	1	0	1	1	0	4	2	2	1	1	3	2	5	1	3	3	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:179440200A>T	uc003mll.1	-	3	961	c.554T>A	c.(553-555)ATG>AAG	p.M185K	RNF130_uc003mlm.1_Missense_Mutation_p.M185K	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130 precursor	185	Extracellular (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTTCGGTGGCATTCGAGTTCC	0.373													26	74					0	0	0	0	T	179440200	T	T	179440200	3	4	81	1	0	0	0	0	1	0	0	0	13503	217	8	5	733	5	RNF130	5	179440200	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	19753442	179440200	1475060	69	16136											
EXOC2	55770	broad.mit.edu	37	chr6	556005	556005	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctcctgtgttttaggttgTtggaagacctgtaaggaaga	9	14	12	6	0	0	2	0	0	0	2	2	4	2	4	3	3	0	4	3	3	4	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:556005T>C	uc003mtd.2	-	19	2075	c.1941A>G	c.(1939-1941)CAA>CAG	p.Q647Q	EXOC2_uc003mte.2_Silent_p.Q647Q|EXOC2_uc011dho.1_Silent_p.Q242Q	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	647					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		TTTTAGGTTGTTGGAAGACCT	0.338													34	40					0	0	0	0	C	556005	C	C	556005	2	2	81	1	0	0	0	0	0	0	0	1	5326	1722	60	5		5	EXOC2	6	556005	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08		556005	170559062	70	16137											
SYCP2L	221711	broad.mit.edu	37	chr6	10907904	10907904	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttcaaagaaattaaggatcGagaatttgagacggtgagat	16	11	11	3	2	1	4	1	2	0	4	2	8	1	5	0	2	0	0	0	2	4	3	rs143568506	by1000genomes	TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:10907904G>C	uc003mzo.2	+	10	1102	c.806G>C	c.(805-807)CGA>CCA	p.R269P	SYCP2L_uc011din.1_Missense_Mutation_p.R110P|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	269						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			ATTAAGGATCGAGAATTTGAG	0.403													35	53					0	0	0	0	C	10907904	C	C	10907904	3	2	81	1	0	0	0	0	1	0	0	0	15499	1058	37	3	844	3	SYCP2L	6	10907904	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	10351899	10907904	160207163	71	16138											
BMP5	653	broad.mit.edu	37	chr6	55620386	55620386	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatattttttcaaaatgacaTtggagctgtcatcaaagtac	14	15	6	6	0	3	1	3	1	0	0	3	2	3	2	0	1	2	2	0	1	6	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:55620386T>A	uc003pcq.2	-	7	2022	c.1310A>T	c.(1309-1311)AAT>ATT	p.N437I	BMP5_uc011dxf.1_Missense_Mutation_p.N400I	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	437					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			CAAAATGACATTGGAGCTGTC	0.353													28	35					0	0	0	0	A	55620386	A	A	55620386	3	1	81	1	0	0	0	0	1	0	0	0	1466	1493	52	5	58	5	BMP5	6	55620386	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	44712482	55620386	115494681	72	16139											
LAMA4	3910	broad.mit.edu	37	chr6	112513043	112513043	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggggtttccatagtaaccGggagcacatctgaagaggaa	14	7	13	7	1	1	2	0	1	1	1	2	4	2	4	2	4	2	3	2	4	5	3	rs140249081		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:112513043G>A	uc003pvu.2	-	6	822	c.513C>T	c.(511-513)CCC>CCT	p.P171P	LAMA4_uc003pvv.2_Silent_p.P171P|LAMA4_uc003pvt.2_Silent_p.P171P	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	171	Laminin EGF-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CATAGTAACCGGGAGCACATC	0.358													6	22					0	0	0	0	A	112513043	A	A	112513043	2	1	81	1	0	0	0	0	0	0	0	1	8648	1103	39	1		1	LAMA4	6	112513043	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	56892657	112513043	58602024	73	16140											
C6orf174	387104	broad.mit.edu	37	chr6	127796905	127796905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctctccttcttgcccgcgtCgctctcggcgtcgctgtcgc	0	12	11	18	7	3	0	0	0	3	0	8	0	3	0	2	1	1	3	2	1	0	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:127796905C>T	uc003qbd.2	-	6	3131	c.2266G>A	c.(2266-2268)GAC>AAC	p.D756N	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	756						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TTGCCCGCGTCGCTCTCGGCG	0.692													24	53					0	0	0	0	T	127796905	T	T	127796905	3	4	81	1	0	0	0	0	1	0	0	0	2355	884	31	1	585	1	C6orf174	6	127796905	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	15283862	127796905	43318162	74	16141											
MAP3K5	4217	broad.mit.edu	37	chr6	136977517	136977517	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atccaaaagtccacaagttcTtgcttggccacaggctgttc	10	11	8	12	0	1	0	0	0	1	0	4	0	3	0	3	2	1	4	3	2	3	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:136977517T>C	uc003qhc.2	-	10	1969	c.1608A>G	c.(1606-1608)CAA>CAG	p.Q536Q	MAP3K5_uc011edj.1_5'UTR|MAP3K5_uc011edk.1_Silent_p.Q381Q|MAP3K5_uc010kgw.1_Silent_p.Q536Q	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	536					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		CCACAAGTTCTTGCTTGGCCA	0.393													45	94					0	0	0	0	C	136977517	C	C	136977517	2	2	81	1	0	0	0	0	0	0	0	1	9306	1606	56	5		5	MAP3K5	6	136977517	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	9180612	136977517	34137550	75	16142											
OLIG3	167826	broad.mit.edu	37	chr6	137814642	137814642	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcccagctgcagcgcgggCggcgtggagggcgccttgag	4	5	19	13	5	0	1	0	1	0	0	0	2	0	2	2	4	4	2	2	4	0	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:137814642C>T	uc003qhp.1	-	1	890	c.666G>A	c.(664-666)CCG>CCA	p.P222P		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		GCAGCGCGGGCGGCGTGGAGG	0.711													3	2					0	0	0	0	T	137814642	T	T	137814642	2	4	81	1	0	0	0	0	0	0	0	1	10916	755	27	1		1	OLIG3	6	137814642	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	837125	137814642	33300425	76	16143											
FBXO30	84085	broad.mit.edu	37	chr6	146127529	146127529	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacacaatgggaatgctgcaGctcctcctccataatggcca	11	8	8	14	0	0	0	0	0	0	0	3	1	3	1	4	2	3	3	4	2	3	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:146127529G>A	uc003qla.2	-	2	212	c.13C>T	c.(13-15)CTG>TTG	p.L5L	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	5							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		GAATGCTGCAGCTCCTCCTCC	0.413													10	24					0	0	0	0	A	146127529	A	A	146127529	2	1	81	1	0	0	0	0	0	0	0	1	5772	962	34	4		4	FBXO30	6	146127529	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	8312887	146127529	24987538	77	16144											
PDE10A	10846	broad.mit.edu	37	chr6	165752811	165752811	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cttgtctctgtccatcatagGaataggctgtattcccaatt	9	15	7	10	0	2	0	1	0	1	0	5	1	4	1	2	2	0	2	2	2	5	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:165752811G>A	uc003qun.2	-	21	2345	c.2104C>T	c.(2104-2106)CCT>TCT	p.P702S	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.P632S|PDE10A_uc003quo.2_Missense_Mutation_p.P712S	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	702					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TCCATCATAGGAATAGGCTGT	0.353													22	61					0	0	0	0	A	165752811	A	A	165752811	3	1	81	1	0	0	0	0	1	0	0	0	11684	1174	41	2	247	2	PDE10A	6	165752811	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	19625282	165752811	5362256	78	16145											
DLL1	28514	broad.mit.edu	37	chr6	170592411	170592411	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcgcgtccctgacggcGgtgtcgtcacccttgaggtc	3	10	14	14	5	1	2	1	2	0	0	4	2	2	2	2	3	1	0	2	3	0	1	rs140596420		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:170592411G>A	uc003qxm.2	-	9	2426	c.1956C>T	c.(1954-1956)ACC>ACT	p.T652T		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	652	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CCCTGACGGCGGTGTCGTCAC	0.662													8	35					0	0	0	0	A	170592411	A	A	170592411	2	1	81	1	0	0	0	0	0	0	0	1	4588	1103	39	1		1	DLL1	6	170592411	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	4839600	170592411	522656	79	16146											
MIOS	54468	broad.mit.edu	37	chr7	7628164	7628164	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtacgtgacagagtggcAtttgcttgtaaattccttag	10	13	11	7	1	0	2	0	1	0	1	1	2	1	2	1	1	2	5	1	1	4	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:7628164A>G	uc003srf.2	+	8	2162	c.1854A>G	c.(1852-1854)GCA>GCG	p.A618A	MIOS_uc003srg.2_Silent_p.A153A|MIOS_uc010ktq.2_Missense_Mutation_p.H16R	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	618											0						ACAGAGTGGCATTTGCTTGTA	0.348													27	36					0	0	0	0	G	7628164	G	G	7628164	2	3	81	1	0	0	0	0	0	0	0	1	9642	204	8	5		5	MIOS	7	7628164	Silent	SNP	A	TCGA-CN-6024-01A-11D-1683-08		7628164	151510499	80	16147											
AMPH	273	broad.mit.edu	37	chr7	38530702	38530702	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtgttagcaaggacccaTccacgagtttttgatggaag	11	10	11	9	1	0	1	0	1	0	0	1	4	1	3	3	2	1	3	3	2	3	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:38530702T>C	uc003tgu.2	-	5	413	c.344A>G	c.(343-345)GAT>GGT	p.D115G	AMPH_uc003tgv.2_Missense_Mutation_p.D115G	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	115	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CAAGGACCCATCCACGAGTTT	0.398													42	174					0	0	0	0	C	38530702	C	C	38530702	3	2	81	1	0	0	0	0	1	0	0	0	588	1435	50	5	1811	5	AMPH	7	38530702	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	30902538	38530702	120607961	81	16148											
ZNF479	90827	broad.mit.edu	37	chr7	57188062	57188062	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggccacattcttcacaggCatagggtttctctctagtat	8	15	8	10	0	4	0	1	0	3	0	5	0	4	0	1	3	0	3	1	3	3	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:57188062C>T	uc010kzo.2	-	5	1331	c.1060G>A	c.(1060-1062)GCC>ACC	p.A354T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	354	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TCTTCACAGGCATAGGGTTTC	0.443													4	11					0	0	0	0	T	57188062	T	T	57188062	3	4	81	1	0	0	0	0	1	0	0	0	18000	710	25	4	518	4	ZNF479	7	57188062	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	18657360	57188062	101950601	82	16149											
SRCRB4D	136853	broad.mit.edu	37	chr7	76021316	76021316	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgggcacccgcgtggtcTcagaaccatcctgctggact	7	8	13	13	2	1	1	1	0	1	1	3	3	2	2	3	3	2	2	3	3	1	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:76021316T>A	uc003ufb.2	-	10	1724	c.1376A>T	c.(1375-1377)GAG>GTG	p.E459V	SRCRB4D_uc003ufa.2_5'UTR	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	459						extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						CCGCGTGGTCTCAGAACCATC	0.592													5	10					0	0	0	0	A	76021316	A	A	76021316	3	1	81	1	0	0	0	0	1	0	0	0	15203	1551	54	5	359	5	SRCRB4D	7	76021316	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	18833254	76021316	83117347	83	16150											
PON1	5444	broad.mit.edu	37	chr7	94931578	94931578	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcatgccattgggatggcatCcaacccaaaggtctcctgtc	9	10	9	13	0	2	0	1	0	1	0	5	1	3	1	4	3	2	1	4	3	2	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:94931578C>G	uc003uns.2	-	8	945	c.848G>C	c.(847-849)GGA>GCA	p.G283A	PON1_uc011kih.1_Missense_Mutation_p.G283A	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	283					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	GGGATGGCATCCAACCCAAAG	0.388													13	65					0	0	0	0	G	94931578	G	G	94931578	3	3	81	1	0	0	0	0	1	0	0	0	12303	855	30	2	227	2	PON1	7	94931578	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	18910262	94931578	64207085	84	16151											
ARPC1A	10552	broad.mit.edu	37	chr7	98931012	98931012	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttactagagccaatcacCtgtcatgcctggaacaggga	11	11	9	10	0	2	1	2	0	0	1	2	3	2	3	3	2	4	0	3	2	4	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:98931012C>T	uc003upx.1	+	2	183	c.36C>T	c.(34-36)ACC>ACT	p.T12T	ARPC1A_uc010lfu.1_RNA|ARPC1A_uc003upy.1_5'UTR|ARPC1A_uc011kit.1_RNA	NM_006409	NP_006400	Q92747	ARC1A_HUMAN	actin related protein 2/3 complex subunit 1A	12	WD 1.				actin cytoskeleton organization|regulation of actin filament polymerization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	all_cancers(62;4.46e-09)|all_epithelial(64;3.44e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0258)		STAD - Stomach adenocarcinoma(171;0.215)			AGCCAATCACCTGTCATGCCT	0.343													14	32					0	0	0	0	T	98931012	T	T	98931012	2	4	81	1	0	0	0	0	0	0	0	1	971	668	24	4		4	ARPC1A	7	98931012	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	3999434	98931012	60207651	85	16152											
CTTNBP2	83992	broad.mit.edu	37	chr7	117351772	117351772	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttaactcttgaaacacccAactcagtctttgatttactg	12	15	4	10	0	3	2	1	2	2	0	3	2	3	2	1	0	4	0	1	0	4	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:117351772A>T	uc003vjf.2	-	23	4903	c.4811T>A	c.(4810-4812)TTG>TAG	p.L1604*		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1604										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGAAACACCCAACTCAGTCTT	0.423													60	54					0	0	0	0	T	117351772	T	T	117351772	4	4	81	1	0	0	0	0	0	1	0	0	4062	131	5	5	184	5	CTTNBP2	7	117351772	Nonsense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	18420760	117351772	41786891	86	16153											
CADPS2	93664	broad.mit.edu	37	chr7	122091450	122091450	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaatggcttatctgattttCtaaaagggaagagagtctct	13	13	10	5	0	3	2	0	1	3	1	4	5	3	3	0	2	0	1	0	2	5	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:122091450C>G	uc010lkp.2	-	14	2429	c.2266G>C	c.(2266-2268)GAA>CAA	p.E756Q	CADPS2_uc011knx.1_Missense_Mutation_p.E127Q|CADPS2_uc003vkg.3_Missense_Mutation_p.E453Q|CADPS2_uc010lkq.2_Missense_Mutation_p.E753Q	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	756	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						ATCTGATTTTCTAAAAGGGAA	0.299													5	30					0	0	0	0	G	122091450	G	G	122091450	3	3	81	1	0	0	0	0	1	0	0	0	2583	922	32	2	1732	2	CADPS2	7	122091450	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	4739678	122091450	37047213	87	16154											
TRIM24	8805	broad.mit.edu	37	chr7	138252382	138252382	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagatggctttcttggctCaacaagccataaaacaggta	14	10	8	9	0	2	1	1	0	1	1	2	1	2	1	1	3	4	3	1	3	6	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:138252382C>A	uc003vuc.2	+	10	1902	c.1687C>A	c.(1687-1689)CAA>AAA	p.Q563K	TRIM24_uc003vub.2_Missense_Mutation_p.Q529K	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	563					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						TTTCTTGGCTCAACAAGCCAT	0.388													10	44					5.61819e-17	6.63178e-17	1	0	A	138252382	A	A	138252382	3	1	81	1	0	0	0	0	1	0	0	0	16565	827	29	2	1725	2	TRIM24	7	138252382	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	16160932	138252382	20886281	88	16155											
SSPO	23145	broad.mit.edu	37	chr7	149474828	149474828	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taccgcacctttgatggccgCcactatcacttcctgggccg	6	10	9	16	3	1	1	1	1	0	0	2	1	2	1	6	2	1	1	6	2	2	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:149474828C>T	uc010lpk.2	+	5	627	c.627C>T	c.(625-627)CGC>CGT	p.R209R	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	209	VWFD 1.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTGATGGCCGCCACTATCACT	0.697													12	13					0	0	0	0	T	149474828	T	T	149474828	2	4	81	1	0	0	0	0	0	0	0	1	15255	726	26	4		4	SSPO	7	149474828	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	11222446	149474828	9663835	89	16156											
RP1	6101	broad.mit.edu	37	chr8	55541985	55541985	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgccaaggaaagaatagCaaatcatcatacagaggaga	18	6	10	7	0	2	3	2	0	0	3	2	5	2	4	1	2	3	1	1	2	6	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:55541985C>A	uc003xsd.1	+	4	5691	c.5543C>A	c.(5542-5544)GCA>GAA	p.A1848E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1848					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GAAAGAATAGCAAATCATCAT	0.413													11	78					2.80697e-09	3.1356e-09	1	0	A	55541985	A	A	55541985	3	1	81	1	0	0	0	0	1	0	0	0	13597	710	25	4	5553	4	RP1	8	55541985	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08		55541985	90822037	90	16157											
CYP7A1	1581	broad.mit.edu	37	chr8	59410989	59410989	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagagcacagcccaggtaTggaattaatccattctctag	12	10	9	10	0	1	1	0	0	1	1	3	2	2	2	2	2	3	3	2	2	4	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:59410989T>C	uc003xtm.3	-	2	183	c.120A>G	c.(118-120)CCA>CCG	p.P40P		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	40					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				AGCCCAGGTATGGAATTAATC	0.418									Neonatal_Giant_Cell_Hepatitis				72	210					0	0	0	0	C	59410989	C	C	59410989	2	2	81	1	0	0	0	0	0	0	0	1	4213	1451	51	5		5	CYP7A1	8	59410989	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	3869004	59410989	86953033	91	16158											
SLCO5A1	81796	broad.mit.edu	37	chr8	70744483	70744483	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtacccagagaccattaaCgcctggatgaaggtcagaaa	15	6	11	9	1	1	3	1	1	0	2	1	5	1	4	3	3	2	1	3	3	4	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:70744483C>T	uc003xyl.2	-	2	1133	c.426G>A	c.(424-426)GCG>GCA	p.A142A	SLCO5A1_uc010lzb.2_Silent_p.A142A|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Silent_p.A142A|SLCO5A1_uc010lzc.2_Silent_p.A142A	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	142	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			AGACCATTAACGCCTGGATGA	0.557											OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	52					0	0	0	0	T	70744483	T	T	70744483	2	4	81	1	0	0	0	0	0	0	0	1	14795	523	19	1		1	SLCO5A1	8	70744483	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	11333494	70744483	75619539	92	16159											
ATP6V0D2	245972	broad.mit.edu	37	chr8	87163762	87163762	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attggaggacgtgttttacgAgcgtgaggtatgatataagt	11	13	14	3	3	0	2	0	2	0	0	0	5	0	4	0	3	2	2	0	3	4	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:87163762A>G	uc003ydp.1	+	7	953	c.884A>G	c.(883-885)GAG>GGG	p.E295G		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	295					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0						GTGTTTTACGAGCGTGAGGTA	0.328													15	51					0	0	0	0	G	87163762	G	G	87163762	3	3	81	1	0	0	0	0	1	0	0	0	1176	304	11	5	910	5	ATP6V0D2	8	87163762	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	16419279	87163762	59200260	93	16160											
VPS13B	157680	broad.mit.edu	37	chr8	100789144	100789144	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctttccagtttgctcacctGgaattccatctttgtcatca	7	17	5	12	0	5	0	3	0	2	0	7	1	7	1	3	1	1	2	3	1	1	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:100789144G>A	uc003yiv.2	+	41	7575	c.7464G>A	c.(7462-7464)CTG>CTA	p.L2488L	VPS13B_uc003yiw.2_Silent_p.L2463L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2488					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTGCTCACCTGGAATTCCATC	0.438													84	226					0	0	0	0	A	100789144	A	A	100789144	2	1	81	1	0	0	0	0	0	0	0	1	17258	1335	47	4		4	VPS13B	8	100789144	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	13625382	100789144	45574878	94	16161											
KCNV1	27012	broad.mit.edu	37	chr8	110984585	110984585	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagctcctgcgtggtctggCtcccacttaggctctctacc	4	11	9	17	1	2	0	0	0	2	0	5	0	4	0	4	3	3	3	4	3	2	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:110984585C>A	uc003ynr.3	-	2	1235	c.893G>T	c.(892-894)AGC>ATC	p.S298I	KCNV1_uc010mcw.2_Missense_Mutation_p.S298I	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	298	Extracellular (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CGTGGTCTGGCTCCCACTTAG	0.562													14	48					2.32078e-09	2.61803e-09	1	0	A	110984585	A	A	110984585	3	1	81	1	0	0	0	0	1	0	0	0	8133	797	28	4	617	4	KCNV1	8	110984585	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	10195441	110984585	35379437	95	16162											
GSDMC	56169	broad.mit.edu	37	chr8	130765053	130765053	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcacagtagcctaccatttcGgaaatttcgtactcttggga	10	12	9	10	2	1	0	0	0	1	0	3	2	1	2	2	2	3	3	2	2	4	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:130765053G>A	uc003ysr.2	-	7	1617	c.735C>T	c.(733-735)TCC>TCT	p.S245S		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	245						mitochondrion				ovary(2)|skin(1)	3						ctaccatttcggaaatttcgt	0													13	86					0	0	0	0	A	130765053	A	A	130765053	2	1	81	1	0	0	0	0	0	0	0	1	6857	1103	39	1		1	GSDMC	8	130765053	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	19780468	130765053	15598969	96	16163											
TG	7038	broad.mit.edu	37	chr8	133881999	133881999	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtgccagaacgacggcCgctcctgctggtgtgtgggt	5	9	15	12	3	0	1	0	0	0	1	2	2	2	1	4	3	3	2	4	3	1	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:133881999C>A	uc003ytw.2	+	3	243	c.202C>A	c.(202-204)CGC>AGC	p.R68S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	68	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GAACGACGGCCGCTCCTGCTG	0.652													61	40					1.41401e-22	1.73159e-22	1	0	A	133881999	A	A	133881999	3	1	81	1	0	0	0	0	1	0	0	0	15879	652	23	3	212	3	TG	8	133881999	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	3116946	133881999	12482023	97	16164											
ZFAT	57623	broad.mit.edu	37	chr8	135524795	135524795	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacgtcttcttcggcctctGtgatgtggagatactgggtg	6	13	14	8	2	3	2	0	1	3	1	4	4	3	2	1	3	2	0	1	3	2	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:135524795G>A	uc003yup.2	-	14	3459	c.3284C>T	c.(3283-3285)ACA>ATA	p.T1095I	ZFAT_uc011ljj.1_Missense_Mutation_p.T214I|ZFAT_uc003yun.2_Missense_Mutation_p.T1083I|ZFAT_uc003yuo.2_Missense_Mutation_p.T1083I|ZFAT_uc010meh.2_Intron|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.T1083I|ZFAT_uc010mej.2_Missense_Mutation_p.T1033I	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	1095					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TTCGGCCTCTGTGATGTGGAG	0.522													34	229					0	0	0	0	A	135524795	A	A	135524795	3	1	81	1	0	0	0	0	1	0	0	0	17699	1377	48	4	459	4	ZFAT	8	135524795	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	1642796	135524795	10839227	98	16165											
TRPM3	80036	broad.mit.edu	37	chr9	73399062	73399062	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccaaaggccaggatgtcCgatgcccgtccactcccatc	8	7	9	17	2	0	0	0	0	0	0	4	2	3	1	6	2	2	0	6	2	1	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:73399062C>T	uc004aid.2	-	7	1351	c.1107G>A	c.(1105-1107)TCG>TCA	p.S369S	TRPM3_uc004ahu.2_Silent_p.S199S|TRPM3_uc004ahv.2_Silent_p.S199S|TRPM3_uc004ahw.2_Silent_p.S241S|TRPM3_uc004ahx.2_Silent_p.S216S|TRPM3_uc004ahy.2_Silent_p.S241S|TRPM3_uc004ahz.2_Silent_p.S216S|TRPM3_uc004aia.2_Silent_p.S216S|TRPM3_uc004aib.2_Silent_p.S216S|TRPM3_uc004aic.2_Silent_p.S369S|TRPM3_uc010mor.2_Silent_p.S369S|TRPM3_uc004aie.2_Silent_p.S216S|TRPM3_uc004aif.2_Silent_p.S241S|TRPM3_uc004aig.2_Silent_p.S216S	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	394	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CCAGGATGTCCGATGCCCGTC	0.527													33	19					0	0	0	0	T	73399062	T	T	73399062	2	4	81	1	0	0	0	0	0	0	0	1	16654	639	23	1		1	TRPM3	9	73399062	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08		73399062	67814369	99	16166											
PRUNE2	158471	broad.mit.edu	37	chr9	79323433	79323433	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aacatttgctgaatggctggGgatttcaggaggcaattccc	10	11	12	8	0	1	1	1	1	0	0	2	3	2	3	1	5	2	3	1	5	3	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:79323433G>T	uc010mpk.2	-	8	3881	c.3757C>A	c.(3757-3759)CCC>ACC	p.P1253T		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1253					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GAATGGCTGGGGATTTCAGGA	0.453													22	11					2.21704e-12	2.56415e-12	1	0	T	79323433	T	T	79323433	3	4	81	1	0	0	0	0	1	0	0	0	12703	1232	43	4	5557	4	PRUNE2	9	79323433	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	5924371	79323433	61889998	100	16167											
COL15A1	1306	broad.mit.edu	37	chr9	101816858	101816858	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgtatgtgtttggtggcagGtgttaaaggagagaaaggat	12	12	16	1	0	0	1	0	0	0	1	0	4	0	3	0	5	0	4	0	5	4	3	rs140851301	by1000genomes	TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:101816858G>T	uc004azb.1	+	32	3157	c.2951G>T	c.(2950-2952)GGT>GTT	p.G984V		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	984	Triple-helical region 6 (COL6).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TTGGTGGCAGGTGTTAAAGGA	0.433													21	8					3.62473e-10	4.12967e-10	1	0	T	101816858	T	T	101816858	3	4	81	1	0	0	0	0	1	0	0	0	3687	1275	44	4	3077	4	COL15A1	9	101816858	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	22493425	101816858	39396573	101	16168											
OR13F1	138805	broad.mit.edu	37	chr9	107267404	107267404	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaacccccatgttgaatccTatcatctatagtctacggaa	13	11	5	12	1	3	1	1	1	2	0	4	2	4	2	3	1	2	1	3	1	7	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:107267404T>C	uc011lvm.1	+	1	861	c.861T>C	c.(859-861)CCT>CCC	p.P287P		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						TGTTGAATCCTATCATCTATA	0.418													41	6					0	0	0	0	C	107267404	C	C	107267404	2	2	81	1	0	0	0	0	0	0	0	1	10995	1509	53	5		5	OR13F1	9	107267404	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	5450546	107267404	33946027	102	16169											
C9orf43	257169	broad.mit.edu	37	chr9	116191548	116191548	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgccaggcaaaagaagatctCctttaacttttcagaaatta	15	12	6	8	0	2	3	1	0	1	3	3	3	2	3	2	1	2	1	2	1	6	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:116191548C>T	uc004bho.3	+	14	1664	c.1268C>T	c.(1267-1269)TCC>TTC	p.S423F	C9orf43_uc004bhp.2_Missense_Mutation_p.S423F	NM_152786	NP_689999	Q8TAL5	CI043_HUMAN	hypothetical protein LOC257169	423											0						AAGAAGATCTCCTTTAACTTT	0.468													19	67					0	0	0	0	T	116191548	T	T	116191548	3	4	81	1	0	0	0	0	1	0	0	0	2495	855	30	2	1318	2	C9orf43	9	116191548	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	8924144	116191548	25021883	103	16170											
ZER1	10444	broad.mit.edu	37	chr9	131515598	131515598	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaggcagccagggagttaagCggccgcagcagggactccac	11	3	15	12	2	0	0	0	0	0	0	1	2	1	2	3	4	3	4	3	4	2	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:131515598C>T	uc004bwa.1	-	4	1024	c.591G>A	c.(589-591)CCG>CCA	p.P197P		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	197					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						GGGAGTTAAGCGGCCGCAGCA	0.602													8	5					0	0	0	0	T	131515598	T	T	131515598	2	4	81	1	0	0	0	0	0	0	0	1	17692	755	27	1		1	ZER1	9	131515598	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	15324050	131515598	9697833	104	16171											
DCLRE1C	64421	broad.mit.edu	37	chr10	14961768	14961768	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaactgttctagctctcttCagttttcccagtggtttata	7	18	7	9	0	3	1	1	1	2	0	5	1	4	1	1	1	2	4	1	1	4	8			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr10:14961768C>A	uc001inn.2	-	13	1210	c.1125G>T	c.(1123-1125)CTG>CTT	p.L375L	DCLRE1C_uc010qbx.1_Silent_p.L375L|DCLRE1C_uc001ink.2_Silent_p.L28L|DCLRE1C_uc001inl.2_Silent_p.L255L|DCLRE1C_uc009xji.2_Silent_p.L260L|DCLRE1C_uc001inm.2_Silent_p.L255L|DCLRE1C_uc001ino.2_Silent_p.L260L|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_Silent_p.L255L|DCLRE1C_uc001inq.2_Silent_p.L255L|DCLRE1C_uc001inr.2_Silent_p.L260L	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	375					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						TAGCTCTCTTCAGTTTTCCCA	0.458								Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					38	81					3.61848e-18	4.36122e-18	1	0	A	14961768	A	A	14961768	2	1	81	1	0	0	0	0	0	0	0	1	4313	813	29	2		2	DCLRE1C	10	14961768	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08		14961768	120572979	105	16172											
GRID1	2894	broad.mit.edu	37	chr10	87966319	87966319	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtgtgggatgtgcatggCatccgtgagggactgcaggg	7	8	20	6	1	0	1	0	1	0	0	1	4	1	3	1	5	2	3	1	5	0	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr10:87966319C>T	uc001kdl.1	-	3	423	c.322G>A	c.(322-324)GCC>ACC	p.A108T	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	108	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	ATGTGCATGGCATCCGTGAGG	0.607										Multiple Myeloma(13;0.14)			14	30					0	0	0	0	T	87966319	T	T	87966319	3	4	81	1	0	0	0	0	1	0	0	0	6810	710	25	4	2763	4	GRID1	10	87966319	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	73004551	87966319	47568428	106	16173											
C10orf12	26148	broad.mit.edu	37	chr10	98743204	98743204	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggctgtgaatgaggtagacaAcgaaaacacccagcagaaag	17	4	12	8	1	0	4	0	2	0	2	0	5	0	4	1	2	3	3	1	2	6	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr10:98743204A>G	uc001kmv.2	+	1	2164	c.2057A>G	c.(2056-2058)AAC>AGC	p.N686S		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	686										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GAGGTAGACAACGAAAACACC	0.502													19	20					0	0	0	0	G	98743204	G	G	98743204	3	3	81	1	0	0	0	0	1	0	0	0	1595	43	2	5	2059	5	C10orf12	10	98743204	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	10776885	98743204	36791543	107	16174											
TACC2	10579	broad.mit.edu	37	chr10	123954555	123954555	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcttctccctctctcatcagGagttccgattctgaagaggc	7	12	9	13	1	5	2	2	1	3	1	8	4	6	3	2	2	0	2	2	2	1	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr10:123954555G>A	uc001lfv.2	+	8	6195	c.5835G>A	c.(5833-5835)AGG>AGA	p.R1945R	TACC2_uc001lfw.2_Silent_p.R91R|TACC2_uc009xzx.2_Silent_p.R1900R|TACC2_uc010qtv.1_Silent_p.R1949R|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Missense_Mutation_p.M23I|TACC2_uc001lga.2_Missense_Mutation_p.M23I|TACC2_uc009xzy.2_Missense_Mutation_p.M23I|TACC2_uc010qtw.1_Silent_p.R40R	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1945						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTCTCATCAGGAGTTCCGATT	0.617													38	96					0	0	0	0	A	123954555	A	A	123954555	2	1	81	1	0	0	0	0	0	0	0	1	15568	1188	41	2		2	TACC2	10	123954555	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	25211351	123954555	11580192	108	16175											
OAT	4942	broad.mit.edu	37	chr10	126100543	126100543	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggattaatttgaaacgtaccTtttcctctctccagggctac	9	14	7	11	1	1	1	0	1	1	0	4	2	3	2	3	2	3	2	3	2	4	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr10:126100543T>C	uc001lhp.2	-	2	305	c.198A>G	c.(196-198)AAA>AAG	p.K66K	OAT_uc001lhq.2_RNA|OAT_uc001lhr.2_Intron	NM_000274	NP_000265	P04181	OAT_HUMAN	ornithine aminotransferase precursor	66					cellular amino acid biosynthetic process|visual perception	mitochondrial matrix	ornithine-oxo-acid transaminase activity|protein binding|pyridoxal phosphate binding				0		all_lung(145;0.0271)|Lung NSC(174;0.0436)|Colorectal(57;0.102)|all_neural(114;0.116)			L-Ornithine(DB00129)|Pyridoxal Phosphate(DB00114)	GAAACGTACCTTTTCCTCTCT	0.363													3	92					0	0	0	0	C	126100543	C	C	126100543	2	2	81	1	0	0	0	0	0	0	0	1	10857	1623	56	5		5	OAT	10	126100543	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	2145988	126100543	9434204	109	16176											
UBQLN3	50613	broad.mit.edu	37	chr11	5530480	5530480	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtagggacagaggcagcTgggcactcattgcccatggc	8	7	16	10	0	1	1	1	0	0	1	1	2	1	2	1	5	2	4	1	5	1	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:5530480T>G	uc001may.1	-	2	395	c.309A>C	c.(307-309)CCA>CCC	p.P103P	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	103										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGAGGCAGCTGGGCACTCAT	0.597													11	29					0	0	0	0	G	5530480	G	G	5530480	2	3	81	1	0	0	0	0	0	0	0	1	16966	1567	55	5		5	UBQLN3	11	5530480	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08		5530480	129476036	110	16177											
SBF2	81846	broad.mit.edu	37	chr11	9878164	9878164	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctttcctcatgttgcactAgctcttgctgagttgacttg	5	17	9	10	0	2	2	1	2	1	0	3	2	3	2	1	0	4	6	1	0	1	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:9878164A>T	uc001mib.2	-	19	2342	c.2204T>A	c.(2203-2205)CTA>CAA	p.L735Q	SBF2_uc001mif.3_Missense_Mutation_p.L491Q|uc001mig.2_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	735					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		ATGTTGCACTAGCTCTTGCTG	0.483													59	161					0	0	0	0	T	9878164	T	T	9878164	3	4	81	1	0	0	0	0	1	0	0	0	13924	420	15	5	3433	5	SBF2	11	9878164	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	4347684	9878164	125128352	111	16178											
ABCC8	6833	broad.mit.edu	37	chr11	17496473	17496473	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaatctcacacaccaggaCgaagagcagcatgaaggtca	15	5	10	11	1	2	2	2	1	1	1	3	4	2	3	1	2	3	3	1	2	3	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:17496473C>T	uc001mnc.2	-	2	376	c.250G>A	c.(250-252)GTC>ATC	p.V84I	ABCC8_uc010rcy.1_Missense_Mutation_p.V84I	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	84	Helical; Name=2; (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CACACCAGGACGAAGAGCAGC	0.547													11	20					0	0	0	0	T	17496473	T	T	17496473	3	4	81	1	0	0	0	0	1	0	0	0	58	536	19	1	4647	1	ABCC8	11	17496473	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	7618309	17496473	117510043	112	16179											
ELF5	2001	broad.mit.edu	37	chr11	34502384	34502384	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctttgtccccacatcttTgccagggcttccgatttaac	6	15	6	14	1	1	0	0	0	1	0	4	1	4	0	5	1	2	1	5	1	1	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:34502384T>A	uc001mvo.1	-	6	866	c.636A>T	c.(634-636)GCA>GCT	p.A212A	ELF5_uc001mvp.1_Silent_p.A202A|ELF5_uc009ykd.1_Silent_p.A107A	NM_198381	NP_938195	Q9UKW6	ELF5_HUMAN	E74-like factor 5 ESE-2a	212	ETS.				cell proliferation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.0087)|all_hematologic(20;0.0384)				CCCACATCTTTGCCAGGGCTT	0.418													52	64					0	0	0	0	A	34502384	A	A	34502384	2	1	81	1	0	0	0	0	0	0	0	1	5081	1799	63	5		5	ELF5	11	34502384	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	17005911	34502384	100504132	113	16180											
LRRC4C	57689	broad.mit.edu	37	chr11	40137317	40137317	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caattcccctaagtctagtcGgcgcaaagaaggaattctgt	12	10	9	10	2	2	1	0	0	2	1	4	2	3	2	2	2	0	1	2	2	6	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:40137317G>T	uc001mxa.1	-	2	2490	c.526C>A	c.(526-528)CGA>AGA	p.R176R	LRRC4C_uc001mxc.1_Silent_p.R172R|LRRC4C_uc001mxd.1_Silent_p.R172R|LRRC4C_uc001mxb.1_Silent_p.R172R	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	176	LRR 5.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				AAGTCTAGTCGGCGCAAAGAA	0.423													32	38					6.00712e-18	7.16475e-18	1	0	T	40137317	T	T	40137317	2	4	81	1	0	0	0	0	0	0	0	1	9058	1124	39	3		3	LRRC4C	11	40137317	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	5634933	40137317	94869199	114	16181											
FOLH1	2346	broad.mit.edu	37	chr11	49207301	49207301	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacgctggacaccacctccaGgaagattccaaccatctgga	12	6	8	15	1	1	1	0	0	1	1	3	4	3	4	5	3	1	1	5	3	2	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:49207301G>A	uc001ngy.2	-	6	1007	c.746C>T	c.(745-747)CCT>CTT	p.P249L	FOLH1_uc001ngz.2_Missense_Mutation_p.P249L|FOLH1_uc009yly.2_Missense_Mutation_p.P234L|FOLH1_uc009ylz.2_Missense_Mutation_p.P234L|FOLH1_uc009yma.2_Intron	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	249	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	ACCACCTCCAGGAAGATTCCA	0.512													12	35					0	0	0	0	A	49207301	A	A	49207301	3	1	81	1	0	0	0	0	1	0	0	0	6011	1000	35	4	1562	4	FOLH1	11	49207301	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	9069984	49207301	85799215	115	16182											
OR4A16	81327	broad.mit.edu	37	chr11	55111275	55111275	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggactcactgtggttgccaAtggtggaataatttgtatgg	10	13	13	5	0	1	0	1	0	0	0	1	2	1	2	1	5	1	2	1	5	4	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:55111275A>G	uc010rie.1	+	1	599	c.599A>G	c.(598-600)AAT>AGT	p.N200S		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						GTGGTTGCCAATGGTGGAATA	0.423													58	60					0	0	0	0	G	55111275	G	G	55111275	3	3	81	1	0	0	0	0	1	0	0	0	11095	101	4	5	601	5	OR4A16	11	55111275	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	5903974	55111275	79895241	116	16183											
CCDC88B	283234	broad.mit.edu	37	chr11	64116884	64116884	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgagctggagcaggcggctCtcgagcgccaggaatttctg	7	8	16	10	3	2	1	0	1	2	0	3	4	2	3	1	4	3	3	1	4	1	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:64116884C>T	uc001nzy.2	+	15	2742	c.2698C>T	c.(2698-2700)CTC>TTC	p.L900F	CCDC88B_uc009ypo.1_Missense_Mutation_p.L897F|CCDC88B_uc001nzz.1_Missense_Mutation_p.L549F|CCDC88B_uc001oaa.2_Missense_Mutation_p.L52F	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	900	Potential.				microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						GCAGGCGGCTCTCGAGCGCCA	0.507													4	23					0	0	0	0	T	64116884	T	T	64116884	3	4	81	1	0	0	0	0	1	0	0	0	2877	913	32	2	2756	2	CCDC88B	11	64116884	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	9005609	64116884	70889632	117	16184											
SPTBN2	6712	broad.mit.edu	37	chr11	66466927	66466927	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttgtcggcgtggatgttGccttcagataccagctggcg	6	12	13	10	3	2	1	1	0	1	1	3	2	2	2	2	3	3	2	2	3	1	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:66466927G>T	uc001ojd.2	-	17	3798	c.3726C>A	c.(3724-3726)GGC>GGA	p.G1242G		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1242	Spectrin 9.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CGTGGATGTTGCCTTCAGATA	0.557													23	50					3.08376e-08	3.41151e-08	1	0	T	66466927	T	T	66466927	2	4	81	1	0	0	0	0	0	0	0	1	15186	1306	46	4		4	SPTBN2	11	66466927	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	2350043	66466927	68539589	118	16185											
ME3	10873	broad.mit.edu	37	chr11	86198421	86198421	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actcatccagcaagtcatcgTatgccttcccgtgcacgcgc	8	9	8	16	4	2	0	2	0	0	0	5	0	4	0	3	0	3	3	3	0	2	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:86198421T>G	uc001pbz.2	-	6	1021	c.767A>C	c.(766-768)TAC>TCC	p.Y256S	ME3_uc001pca.2_Missense_Mutation_p.Y256S|ME3_uc009yvk.2_Missense_Mutation_p.Y256S|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	256					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	CAAGTCATCGTATGCCTTCCC	0.527													11	39					0	0	0	0	G	86198421	G	G	86198421	3	3	81	1	0	0	0	0	1	0	0	0	9472	1638	57	5	1083	5	ME3	11	86198421	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	19731494	86198421	48808095	119	16186											
FAT3	120114	broad.mit.edu	37	chr11	92087366	92087366	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaaagctggcagagaaactActcattaaggcaaaagcaaa	20	5	8	8	0	1	1	1	0	0	1	1	2	1	1	0	2	4	4	0	2	8	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:92087366A>G	uc001pdj.3	+	1	2105	c.2088A>G	c.(2086-2088)CTA>CTG	p.L696L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	696	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGAGAAACTACTCATTAAGG	0.388										TCGA Ovarian(4;0.039)			19	44					0	0	0	0	G	92087366	G	G	92087366	2	3	81	1	0	0	0	0	0	0	0	1	5723	378	14	5		5	FAT3	11	92087366	Silent	SNP	A	TCGA-CN-6024-01A-11D-1683-08	5888945	92087366	42919150	120	16187											
ATM	472	broad.mit.edu	37	chr11	108115564	108115564	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atatcttagcagctcttactAtcttcctcaagactttggct	9	16	5	11	0	4	1	1	0	3	1	5	1	5	1	1	1	3	3	1	1	5	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:108115564A>G	uc001pkb.1	+	7	1097	c.712A>G	c.(712-714)ATC>GTC	p.I238V	ATM_uc009yxr.1_Missense_Mutation_p.I238V	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	238					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGCTCTTACTATCTTCCTCAA	0.393			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			28	65					0	0	0	0	G	108115564	G	G	108115564	3	3	81	1	0	0	0	0	1	0	0	0	1111	449	16	5	734	5	ATM	11	108115564	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	16028198	108115564	26890952	121	16188											
ATM	472	broad.mit.edu	37	chr11	108143284	108143284	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taacaaaggagaggaaatatAtattctctgtaagaatggcc	17	10	9	5	0	1	2	0	0	1	2	2	4	1	3	1	3	1	1	1	3	8	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:108143284A>G	uc001pkb.1	+	21	3488	c.3103A>G	c.(3103-3105)ATA>GTA	p.I1035V	ATM_uc009yxr.1_Missense_Mutation_p.I1035V	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1035					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GAGGAAATATATATTCTCTGT	0.308			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			10	25					0	0	0	0	G	108143284	G	G	108143284	3	3	81	1	0	0	0	0	1	0	0	0	1111	449	16	5	3181	5	ATM	11	108143284	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	27720	108143284	26863232	122	16189											
C11orf53	341032	broad.mit.edu	37	chr11	111155057	111155057	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcgcctcgcccctaccgccGctcctgccaccgcccttccc	3	6	7	25	5	0	0	0	0	0	0	3	0	2	0	10	0	3	1	10	0	1	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:111155057G>A	uc001plc.2	+	3	411	c.264G>A	c.(262-264)CCG>CCA	p.P88P		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	88											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		CCCTACCGCCGCTCCTGCCAC	0.662													7	19					0	0	0	0	A	111155057	A	A	111155057	2	1	81	1	0	0	0	0	0	0	0	1	1654	1074	38	1		1	C11orf53	11	111155057	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	3011773	111155057	23851459	123	16190											
BSX	390259	broad.mit.edu	37	chr11	122848579	122848579	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tttttatgcttcatccgccgGttctggaaccacgttttcac	6	16	7	12	3	3	0	2	0	1	0	4	1	4	1	3	2	2	3	3	2	2	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:122848579G>A	uc010rzs.1	-	3	480	c.480C>T	c.(478-480)AAC>AAT	p.N160N		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	160	Homeobox.										0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		TCATCCGCCGGTTCTGGAACC	0.527													17	26					0	0	0	0	A	122848579	A	A	122848579	2	1	81	1	0	0	0	0	0	0	0	1	1540	1252	44	4		4	BSX	11	122848579	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	11693522	122848579	12157937	124	16191											
ITPR2	3709	broad.mit.edu	37	chr12	26812177	26812177	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgccaaaatatcatagccAatctgggactgcatgacaca	14	9	7	11	0	3	1	1	1	2	0	3	2	3	2	2	1	3	1	2	1	5	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:26812177A>C	uc001rhg.2	-	16	2172	c.1755T>G	c.(1753-1755)ATT>ATG	p.I585M		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	585	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TATCATAGCCAATCTGGGACT	0.368													11	139					0	0	0	0	C	26812177	C	C	26812177	3	2	81	1	0	0	0	0	1	0	0	0	7960	126	5	5	6518	5	ITPR2	12	26812177	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08		26812177	107039718	125	16192											
ARNTL2	56938	broad.mit.edu	37	chr12	27533231	27533231	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagataaaatgaataacctGattgaagaactgtctgcaat	18	10	8	5	0	1	5	0	3	1	2	1	6	1	5	1	0	3	1	1	0	7	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:27533231G>A	uc001rht.1	+	5	396	c.378G>A	c.(376-378)CTG>CTA	p.L126L	ARNTL2_uc001rhw.2_Silent_p.L89L|ARNTL2_uc010sjp.1_Silent_p.L89L|ARNTL2_uc001rhu.1_Silent_p.L112L|ARNTL2_uc009zji.1_Silent_p.L92L|ARNTL2_uc001rhv.1_Silent_p.L78L	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	126	Helix-loop-helix motif.				circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					TGAATAACCTGATTGAAGAAC	0.418													17	132					0	0	0	0	A	27533231	A	A	27533231	2	1	81	1	0	0	0	0	0	0	0	1	970	1277	45	2		2	ARNTL2	12	27533231	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	721054	27533231	106318664	126	16193											
CNTN1	1272	broad.mit.edu	37	chr12	41302265	41302265	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttgctggtcagtcatcttGtgataatatctattactacc	9	16	8	8	0	4	1	2	1	2	0	4	1	4	1	1	2	3	2	1	2	5	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:41302265G>T	uc001rmm.1	+	2	144	c.31G>T	c.(31-33)GTG>TTG	p.V11L	CNTN1_uc009zjy.1_Missense_Mutation_p.V11L|CNTN1_uc001rmn.1_Missense_Mutation_p.V11L|CNTN1_uc001rmo.2_Missense_Mutation_p.V11L	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	11					axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CAGTCATCTTGTGATAATATC	0.299													26	21					1.55811e-20	1.89791e-20	1	0	T	41302265	T	T	41302265	3	4	81	1	0	0	0	0	1	0	0	0	3655	1377	48	4	33	4	CNTN1	12	41302265	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	13769034	41302265	92549630	127	16194											
PRPF40B	25766	broad.mit.edu	37	chr12	50027756	50027756	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgtgcctcctggccccacCccagtgcccacaggcctcct	4	7	8	22	0	0	0	0	0	0	0	2	0	2	0	10	2	2	0	10	2	0	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:50027756C>T	uc001rur.1	+	9	691	c.627C>T	c.(625-627)ACC>ACT	p.T209T	PRPF40B_uc001rup.1_Silent_p.T231T|PRPF40B_uc001ruq.1_Silent_p.T203T|PRPF40B_uc001rus.1_Silent_p.T152T	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	209					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CTGGCCCCACCCCAGTGCCCA	0.642													51	20					0	0	0	0	T	50027756	T	T	50027756	2	4	81	1	0	0	0	0	0	0	0	1	12634	610	22	4		4	PRPF40B	12	50027756	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	8725491	50027756	83824139	128	16195											
RASSF9	9182	broad.mit.edu	37	chr12	86198764	86198764	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagtcactgtatttaatctCtttctggatgccactcaaat	10	16	6	9	0	4	1	2	1	2	0	5	2	4	2	1	1	1	1	1	1	3	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:86198764C>G	uc001taf.1	-	2	1363	c.1024G>C	c.(1024-1026)GAG>CAG	p.E342Q		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	342					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						TATTTAATCTCTTTCTGGATG	0.373													104	68					0	0	0	0	G	86198764	G	G	86198764	3	3	81	1	0	0	0	0	1	0	0	0	13158	922	32	2	287	2	RASSF9	12	86198764	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	36171008	86198764	47653131	129	16196											
APAF1	317	broad.mit.edu	37	chr12	99060113	99060113	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaagtagattttcttacagAgaagaattgcagccagcttc	13	12	8	8	0	2	3	1	0	1	3	3	4	2	3	1	0	4	3	1	0	5	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:99060113A>G	uc001tfz.2	+	9	1917	c.1340A>G	c.(1339-1341)GAG>GGG	p.E447G	APAF1_uc001tfy.2_Missense_Mutation_p.E436G|APAF1_uc001tga.2_Missense_Mutation_p.E436G|APAF1_uc001tgb.2_Missense_Mutation_p.E447G|APAF1_uc001tgc.2_Intron	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	447					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	TTTCTTACAGAGAAGAATTGC	0.254													28	30					0	0	0	0	G	99060113	G	G	99060113	3	3	81	1	0	0	0	0	1	0	0	0	755	304	11	5	1370	5	APAF1	12	99060113	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	12861349	99060113	34791782	130	16197											
SLC5A8	160728	broad.mit.edu	37	chr12	101603574	101603574	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgaccagcatgcccgcgAacaccacgtagtcccacacc	12	4	8	17	3	0	2	0	1	0	1	1	3	1	2	5	0	3	2	5	0	2	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:101603574A>T	uc001thz.3	-	1	443	c.53T>A	c.(52-54)TTC>TAC	p.F18Y		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	18	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						CATGCCCGCGAACACCACGTA	0.692													16	8					0	0	0	0	T	101603574	T	T	101603574	3	4	81	1	0	0	0	0	1	0	0	0	14735	246	9	5	1839	5	SLC5A8	12	101603574	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	2543461	101603574	32248321	131	16198											
DDX55	57696	broad.mit.edu	37	chr12	124104214	124104214	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaaataaagcttggtcaaaGcagaaggccaaaaaagaaaa	24	4	8	5	0	1	2	1	0	0	2	1	2	1	2	1	2	2	2	1	2	11	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:124104214G>A	uc001ufi.2	+	13	1593	c.1569G>A	c.(1567-1569)AAG>AAA	p.K523K	DDX55_uc001ufh.2_3'UTR|DDX55_uc001ufk.2_Silent_p.K376K|DDX55_uc001ufl.2_Silent_p.K130K	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	523	Lys-rich.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		cttggtcaaagcagaaggcca	0.144													7	15					0	0	0	0	A	124104214	A	A	124104214	2	1	81	1	0	0	0	0	0	0	0	1	4390	962	34	4		4	DDX55	12	124104214	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	22500640	124104214	9747681	132	16199											
CDK8	1024	broad.mit.edu	37	chr13	26967636	26967636	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagaatattcaatgtaatggGatttcctgcaggtacacatt	13	13	8	7	0	1	1	1	0	0	1	2	2	2	2	1	2	2	3	1	2	5	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr13:26967636G>T	uc001uqr.1	+	7	805	c.779G>T	c.(778-780)GGA>GTA	p.G260V	CDK8_uc001uqs.1_Missense_Mutation_p.G260V|CDK8_uc001uqt.1_Missense_Mutation_p.G87V	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	260	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AATGTAATGGGATTTCCTGCA	0.353													69	52					5.94106e-25	7.31453e-25	1	0	T	26967636	T	T	26967636	3	4	81	1	0	0	0	0	1	0	0	0	3165	1174	41	2	805	2	CDK8	13	26967636	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08		26967636	88202242	133	16200											
RB1	5925	broad.mit.edu	37	chr13	48951101	48951101	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atactgaaaagagtgaaggaTataggatacatctttaaaga	19	10	9	3	0	1	4	0	2	1	2	1	6	1	6	0	2	2	0	0	2	9	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr13:48951101T>C	uc001vcb.2	+	13	1429	c.1263T>C	c.(1261-1263)GAT>GAC	p.D421D	RB1_uc010act.1_Silent_p.D122D	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	421	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAGTGAAGGATATAGGATACA	0.358		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			28	16					0	0	0	0	C	48951101	C	C	48951101	2	2	81	1	0	0	0	0	0	0	0	1	13163	1403	49	5		5	RB1	13	48951101	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	21983465	48951101	66218777	134	16201											
MLNR	2862	broad.mit.edu	37	chr13	49795353	49795353	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggggcgggagagaggccacCggcagaccgtccgcgtcctg	6	3	18	14	6	0	2	0	0	0	2	2	4	2	3	5	5	0	1	5	5	0	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr13:49795353C>T	uc010tgj.1	+	1	880	c.880C>T	c.(880-882)CGG>TGG	p.R294W		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	294	Cytoplasmic (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		GAGAGGCCACCGGCAGACCGT	0.736													3	2					0	0	0	0	T	49795353	T	T	49795353	3	4	81	1	0	0	0	0	1	0	0	0	9685	643	23	1	882	1	MLNR	13	49795353	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	844252	49795353	65374525	135	16202											
RBM26	64062	broad.mit.edu	37	chr13	79945213	79945213	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctcgtcttctattgtaccgGtctctgtatgaatctcttcg	5	17	7	12	3	4	1	0	1	4	0	8	1	4	1	2	1	1	2	2	1	4	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr13:79945213G>A	uc001vkz.2	-	5	515	c.501C>T	c.(499-501)GAC>GAT	p.D167D	RBM26_uc001vky.2_Silent_p.D167D|RBM26_uc001vla.2_Silent_p.D167D|RBM26_uc001vkx.2_5'Flank|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	167	Arg-rich.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TATTGTACCGGTCTCTGTATG	0.453													49	32					0	0	0	0	A	79945213	A	A	79945213	2	1	81	1	0	0	0	0	0	0	0	1	13191	1252	44	4		4	RBM26	13	79945213	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	30149860	79945213	35224665	136	16203											
ERCC5	2073	broad.mit.edu	37	chr13	103513864	103513864	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttgcctttaggagtctgAtgacttttcacagtaccaac	10	15	7	9	0	2	2	1	2	1	0	2	3	2	3	2	1	3	1	2	1	3	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr13:103513864A>T	uc001vpw.2	+	7	1123	c.680A>T	c.(679-681)GAT>GTT	p.D227V	ERCC5_uc001vpu.1_Missense_Mutation_p.D681V|ERCC5_uc010tjb.1_Missense_Mutation_p.D227V|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.D59V	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	227					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TAGGAGTCTGATGACTTTTCA	0.338			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				36	21					0	0	0	0	T	103513864	T	T	103513864	3	4	81	1	0	0	0	0	1	0	0	0	5240	333	12	5	706	5	ERCC5	13	103513864	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	23568651	103513864	11656014	137	16204											
RNF31	55072	broad.mit.edu	37	chr14	24624491	24624491	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctgtggccgccccgacctCaccgatgacacacagttgct	7	7	10	17	3	1	1	1	1	0	0	1	3	1	1	6	1	1	2	6	1	0	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:24624491C>G	uc001wmn.1	+	12	2505	c.2256C>G	c.(2254-2256)CTC>CTG	p.L752L	RNF31_uc001wml.1_Silent_p.L601L|RNF31_uc001wmm.1_RNA|RNF31_uc010alg.1_Silent_p.L511L|RNF31_uc001wmo.1_Silent_p.L219L|RNF31_uc001wmp.2_RNA|RNF31_uc010alh.1_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	752					CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GCCCCGACCTCACCGATGACA	0.577													40	33					0	0	0	0	G	24624491	G	G	24624491	2	3	81	1	0	0	0	0	0	0	0	1	13552	813	29	2		2	RNF31	14	24624491	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08		24624491	82725049	138	16205											
HECTD1	25831	broad.mit.edu	37	chr14	31581699	31581699	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaaaggacatttgctggtTaattgttcacaccagtctgg	12	12	10	7	0	2	1	1	0	1	1	2	2	2	2	1	3	1	3	1	3	3	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:31581699T>C	uc001wrc.1	-	35	6690	c.6201A>G	c.(6199-6201)TTA>TTG	p.L2067L	HECTD1_uc001wra.1_Silent_p.L193L|HECTD1_uc001wrb.1_Silent_p.L193L	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	2067	K-box.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ATTTGCTGGTTAATTGTTCAC	0.373													16	33					0	0	0	0	C	31581699	C	C	31581699	2	2	81	1	0	0	0	0	0	0	0	1	7078	1751	61	5		5	HECTD1	14	31581699	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	6957208	31581699	75767841	139	16206											
C14orf104	55172	broad.mit.edu	37	chr14	50101425	50101425	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggccagcgcaagcgcgtctGgatggaagaccacgtcgtag	9	5	16	11	5	1	1	0	0	1	1	2	3	1	3	2	3	2	2	2	3	3	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:50101425G>T	uc001wws.3	-	1	524	c.443C>A	c.(442-444)CCA>CAA	p.P148Q	SDCCAG1_uc010anj.1_Intron|C14orf104_uc001wwt.3_Missense_Mutation_p.P148Q	NM_018139	NP_060609	Q9NVR5	KTU_HUMAN	kintoun isoform 1	148					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm					0	all_epithelial(31;0.0021)|Breast(41;0.0124)					AAGCGCGTCTGGATGGAAGAC	0.706									Kartagener_syndrome				8	20					2.52707e-12	2.90803e-12	1	0	T	50101425	T	T	50101425	3	4	81	1	0	0	0	0	1	0	0	0	1742	1348	47	4	2082	4	C14orf104	14	50101425	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	18519726	50101425	57248115	140	16207											
TBPL2	387332	broad.mit.edu	37	chr14	55903569	55903569	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtctttattttcctgggtAacttcatctggtaggaagct	7	17	10	7	0	3	0	1	0	2	0	4	1	4	1	1	4	2	3	1	4	4	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:55903569A>G	uc001xby.2	-	2	318	c.318T>C	c.(316-318)GTT>GTC	p.V106V		NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	106					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						TTTCCTGGGTAACTTCATCTG	0.423													30	33					0	0	0	0	G	55903569	G	G	55903569	2	3	81	1	0	0	0	0	0	0	0	1	15712	349	13	5		5	TBPL2	14	55903569	Silent	SNP	A	TCGA-CN-6024-01A-11D-1683-08	5802144	55903569	51445971	141	16208											
SYNE2	23224	broad.mit.edu	37	chr14	64679605	64679605	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggggagcagctgattcagaAgagcgagcccctggatgctg	9	7	16	9	1	1	3	1	1	0	2	1	6	1	5	2	3	5	3	2	3	1	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:64679605A>G	uc001xgm.2	+	105	19168	c.18938A>G	c.(18937-18939)AAG>AGG	p.K6313R	SYNE2_uc001xgl.2_Missense_Mutation_p.K6313R|SYNE2_uc010apy.2_Missense_Mutation_p.K2698R|SYNE2_uc001xgn.2_Missense_Mutation_p.K1275R|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.K283R|SYNE2_uc001xgq.2_Missense_Mutation_p.K678R|SYNE2_uc001xgr.2_Missense_Mutation_p.K96R|SYNE2_uc010tsi.1_5'Flank|SYNE2_uc001xgs.2_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6313	Spectrin 8.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTGATTCAGAAGAGCGAGCCC	0.522													48	39					0	0	0	0	G	64679605	G	G	64679605	3	3	81	1	0	0	0	0	1	0	0	0	15512	72	3	5	19352	5	SYNE2	14	64679605	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	8776036	64679605	42669935	142	16209											
ACOT2	10965	broad.mit.edu	37	chr14	74036297	74036297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgcgctaccgcgccgacaCtcttggcgagctggacctgg	5	6	14	16	7	1	0	0	0	1	0	1	3	1	1	3	3	2	2	3	3	1	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:74036297C>T	uc001xon.3	+	1	526	c.353C>T	c.(352-354)ACT>ATT	p.T118I	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_Intron	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	118					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		CGCGCCGACACTCTTGGCGAG	0.741													17	16					0	0	0	0	T	74036297	T	T	74036297	3	4	81	1	0	0	0	0	1	0	0	0	152	565	20	4	355	4	ACOT2	14	74036297	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	9356692	74036297	33313243	143	16210											
OTUB2	78990	broad.mit.edu	37	chr14	94510931	94510931	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgagggccgggcgggcgcaGttttacagtgtggtggaact	6	9	18	8	3	0	1	0	1	0	0	0	2	0	2	1	5	2	2	1	5	2	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:94510931G>A	uc001yci.2	+	5	464	c.304_splice	c.e5-1	p.F102_splice		NM_023112	NP_075601	Q96DC9	OTUB2_HUMAN	OTU domain, ubiquitin aldehyde binding 2						cellular amino acid metabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination		omega peptidase activity|protein binding|ubiquitin-specific protease activity				0		all_cancers(154;0.12)		Epithelial(152;0.124)|all cancers(159;0.21)|COAD - Colon adenocarcinoma(157;0.215)		GGCGGGCGCAGTTTTACAGTG	0.622													12	26					0	0	0	0	A	94510931	A	A	94510931	5	1	81	1	0	0	0	0	0	0	1	0	11366	1043	36	4	321	4	OTUB2	14	94510931	Splice_Site	SNP	G	TCGA-CN-6024-01A-11D-1683-08	20474634	94510931	12838609	144	16211											
RYR3	6263	broad.mit.edu	37	chr15	34016286	34016286	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcacgggggacgatgaagAggaagaagaaatcgtgcata	16	4	15	6	3	0	4	0	1	0	3	1	7	0	6	0	3	2	2	0	3	5	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr15:34016286A>T	uc001zhi.2	+	45	6891	c.6821A>T	c.(6820-6822)GAG>GTG	p.E2274V	RYR3_uc010bar.2_Missense_Mutation_p.E2274V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2274	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GACGATGAAGAGGAAGAAGAA	0.502													16	10					0	0	0	0	T	34016286	T	T	34016286	3	4	81	1	0	0	0	0	1	0	0	0	13835	304	11	5	6999	5	RYR3	15	34016286	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08		34016286	68515106	145	16212											
ONECUT1	3175	broad.mit.edu	37	chr15	53081808	53081808	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctcatacctgggggagtctCgcaggccatggtcatggtgg	6	9	16	10	1	3	0	2	0	1	0	4	1	3	1	2	6	1	2	2	6	1	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr15:53081808C>T	uc002aci.1	-	1	402	c.274G>A	c.(274-276)GAG>AAG	p.E92K		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	92					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		GGGGGAGTCTCGCAGGCCATG	0.657													27	13					0	0	0	0	T	53081808	T	T	53081808	3	4	81	1	0	0	0	0	1	0	0	0	10922	893	31	1	1131	1	ONECUT1	15	53081808	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	19065522	53081808	49449584	146	16213											
PRTG	283659	broad.mit.edu	37	chr15	55965703	55965703	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccaaaaggtactcatgcGtggtccccgggagctccaga	9	8	11	13	2	1	1	1	0	0	1	4	2	4	2	4	3	3	2	4	3	3	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr15:55965703G>A	uc002adg.2	-	10	1766	c.1718C>T	c.(1717-1719)ACG>ATG	p.T573M	PRTG_uc002adh.2_Missense_Mutation_p.T75M	NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	573	Fibronectin type-III 2.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GTACTCATGCGTGGTCCCCGG	0.537													39	20					0	0	0	0	A	55965703	A	A	55965703	3	1	81	1	0	0	0	0	1	0	0	0	12700	1145	40	1	1778	1	PRTG	15	55965703	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	2883895	55965703	46565689	147	16214											
IL16	3603	broad.mit.edu	37	chr15	81585276	81585276	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctccaagcccaagcctccAcccagaaaatactttaaaag	15	7	4	15	0	0	1	0	0	0	1	3	1	3	1	6	0	3	0	6	0	7	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr15:81585276A>T	uc002bgh.3	+	12	2176	c.1800A>T	c.(1798-1800)CCA>CCT	p.P600P	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Intron|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Silent_p.P642P|IL16_uc002bgg.2_Silent_p.P600P|IL16_uc002bgi.1_5'UTR|IL16_uc002bgj.2_Silent_p.P94P|IL16_uc002bgk.2_5'Flank	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	600					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						CCAAGCCTCCACCCAGAAAAT	0.547													9	11					0	0	0	0	T	81585276	T	T	81585276	2	4	81	1	0	0	0	0	0	0	0	1	7672	146	6	5		5	IL16	15	81585276	Silent	SNP	A	TCGA-CN-6024-01A-11D-1683-08	25619573	81585276	20946116	148	16215											
RPUSD1	113000	broad.mit.edu	37	chr16	836037	836037	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagggggcttggttgggggTggaggaggccggccgggccc	3	6	23	9	2	1	0	1	0	0	0	1	2	1	2	3	10	0	2	3	10	0	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr16:836037T>A	uc002cka.2	-	5	1086	c.852A>T	c.(850-852)CCA>CCT	p.P284P	RPUSD1_uc002ckb.2_Silent_p.P284P|RPUSD1_uc002ckc.2_Silent_p.P155P|RPUSD1_uc002ckd.2_3'UTR|CHTF18_uc010uus.1_5'Flank|CHTF18_uc010bre.1_5'Flank|CHTF18_uc002cke.3_5'Flank|CHTF18_uc002ckf.3_5'Flank|CHTF18_uc010brf.2_5'Flank|CHTF18_uc002ckg.3_5'Flank	NM_058192	NP_478072	Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing	284	Pro-rich.				pseudouridine synthesis		pseudouridine synthase activity|RNA binding				0		Hepatocellular(780;0.00335)				TGGTTGGGGGTGGAGGAGGCC	0.731													3	6					0	0	0	0	A	836037	A	A	836037	2	1	81	1	0	0	0	0	0	0	0	1	13731	1683	59	5		5	RPUSD1	16	836037	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08		836037	89518716	149	16216											
SLC12A3	6559	broad.mit.edu	37	chr16	56914084	56914084	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acccactgatcggcttcttcGgcaaaggctatggcaagaac	11	8	10	12	2	1	2	0	1	1	1	3	2	1	2	1	4	1	4	1	4	4	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr16:56914084G>A	uc010ccm.2	+	12	1515	c.1486G>A	c.(1486-1488)GGC>AGC	p.G496S	SLC12A3_uc002ekd.3_Missense_Mutation_p.G496S|SLC12A3_uc010ccn.2_Missense_Mutation_p.G495S	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	496	Cytoplasmic (Potential).		G -> C (in GS).		sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	CGGCTTCTTCGGCAAAGGCTA	0.612													5	8					0	0	0	0	A	56914084	A	A	56914084	3	1	81	1	0	0	0	0	1	0	0	0	14449	1116	39	1	1532	1	SLC12A3	16	56914084	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	56078047	56914084	33440669	150	16217											
CDH1	999	broad.mit.edu	37	chr16	68847250	68847255	+	In_Frame_Del	DEL	TCGTAA	-	-																															gcctgagaacgaggctaacgTcgtaatcaccacactgaaag																								rs148080550		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr16:68847250_68847255delTCGTAA	uc002ewg.1	+	9	1296_1301	c.1172_1177delTCGTAA	c.(1171-1179)GTCGTAATC>GTC	p.VI392del	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Intron	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	392_393	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.Y380_K440del(5)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GAGGCTAACGTCGTAATCACCACACT	0.495			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				---	---	---								-	68847255	-	-	68847250	7	5	81	1	0	1	0	1	0	0	0	0	3110	1667	58	0	1206	0	CDH1	16	68847250	In_Frame_Del	DEL	TCGTAA	TCGA-CN-6024-01A-11D-1683-08	11933166	68847250	21507503	151	16218											
HP	3240	broad.mit.edu	37	chr16	72094648	72094648	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgcgggcagtgcctttgcCgttcacgacctggaggagga	7	8	16	10	3	1	0	1	0	0	0	1	5	1	3	3	4	3	2	3	4	0	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr16:72094648C>T	uc002fbr.3	+	7	1124	c.1080C>T	c.(1078-1080)GCC>GCT	p.A360A	TXNL4B_uc010cgl.2_Intron|HP_uc010cgm.2_Silent_p.A301A|HP_uc002fbt.3_Silent_p.A301A|HP_uc002fbu.1_Silent_p.A98A|HP_uc002fbv.3_Silent_p.A271A|HP_uc002fbw.3_Silent_p.A182A|HP_uc002fbx.3_Silent_p.A182A|HPR_uc002fby.2_5'Flank	NM_005143	NP_005134	P00738	HPT_HUMAN	haptoglobin isoform 1 preproprotein	360	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity				0		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		GTGCCTTTGCCGTTCACGACC	0.522													20	69					0	0	0	0	T	72094648	T	T	72094648	2	4	81	1	0	0	0	0	0	0	0	1	7366	639	23	1		1	HP	16	72094648	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	3247398	72094648	18260105	152	16219											
TP53	7157	broad.mit.edu	37	chr17	7577144	7577144	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaaagctgttccgtcccAgtagattaccactactcagg	10	10	7	14	1	2	1	2	0	0	1	4	1	4	1	4	1	3	3	4	1	4	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:7577144A>C	uc002gim.2	-	8	988	c.794T>G	c.(793-795)CTG>CGG	p.L265R	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.L265R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.L133R|TP53_uc010cng.1_Missense_Mutation_p.L133R|TP53_uc002gii.1_Missense_Mutation_p.L133R|TP53_uc010cnh.1_Missense_Mutation_p.L265R|TP53_uc010cni.1_Missense_Mutation_p.L265R|TP53_uc002gij.2_Missense_Mutation_p.L265R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	265	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> M (in sporadic cancers; somatic mutation).|L -> Q (in sporadic cancers; somatic mutation).|L -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L265P(14)|p.0?(7)|p.L265M(4)|p.L265R(3)|p.L265fs*80(3)|p.?(3)|p.L265L(3)|p.G262_F270delGNLLGRNSF(2)|p.L265del(2)|p.G262_S269delGNLLGRNS(2)|p.L265Q(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.L265_R267delLGR(1)|p.L265fs*81(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTCCGTCCCAGTAGATTACC	0.522		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	8					0	0	0	0	C	7577144	C	C	7577144	3	2	81	1	0	0	0	0	1	0	0	0	16448	188	7	5	492	5	TP53	17	7577144	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08		7577144	73618066	153	16220											
CHD3	1107	broad.mit.edu	37	chr17	7797825	7797826	+	Frame_Shift_Ins	INS	-	A	A																															ggtgtgccagcagggtggggINSaaattattctgtgtgacacc																										TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:7797825_7797826insA	uc002gje.2	+	8	1318_1319	c.1168_1169insA	c.(1168-1170)GAAfs	p.E390fs	CHD3_uc002gjd.2_Frame_Shift_Ins_p.E449fs|CHD3_uc002gjf.2_Frame_Shift_Ins_p.E390fs|CHD3_uc002gjg.1_Frame_Shift_Ins_p.E218fs	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	390	PHD-type 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GCAGGGTGGGGAAATTATTCTG	0.589													---	---	---								A	7797826	A	A	7797825	7	5	81	1	0	1	1	0	0	0	0	0	3341	1175	41	0	1479	0	CHD3	17	7797825	Frame_Shift_Ins	INS	-	TCGA-CN-6024-01A-11D-1683-08	220681	7797825	73397385	154	16221											
PIK3R5	23533	broad.mit.edu	37	chr17	8812417	8812417	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcttctgcaggatctgctCaaggaggataaggaagtggc	10	9	15	7	0	4	0	1	0	3	0	4	4	4	4	0	6	2	2	0	6	3	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:8812417C>A	uc002glt.2	-	3	245	c.178G>T	c.(178-180)GAG>TAG	p.E60*	PIK3R5_uc010vuz.1_Nonsense_Mutation_p.E60*|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Nonsense_Mutation_p.E60*|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	60	Heterodimerization (By similarity).				platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						AGGATCTGCTCAAGGAGGATA	0.592													4	5					5.9392e-07	6.41546e-07	1	0	A	8812417	A	A	8812417	4	1	81	1	0	0	0	0	0	1	0	0	11977	835	29	2	2532	2	PIK3R5	17	8812417	Nonsense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	1014592	8812417	72382793	155	16222											
MYH8	4626	broad.mit.edu	37	chr17	10304048	10304048	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcttctccgctttggctcGggacgccctctctgcctcga	2	12	10	17	4	2	0	0	0	2	0	6	2	2	1	3	2	2	3	3	2	0	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:10304048G>T	uc002gmm.2	-	27	3489	c.3394C>A	c.(3394-3396)CGA>AGA	p.R1132R	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1132	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle	p.R1132R(1)		skin(6)|ovary(3)|breast(2)	11						GCTTTGGCTCGGGACGCCCTC	0.557									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				6	51					0.00198382	0.00208392	1	0	T	10304048	T	T	10304048	2	4	81	1	0	0	0	0	0	0	0	1	10094	1124	39	3		3	MYH8	17	10304048	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	1491631	10304048	70891162	156	16223											
MYH4	4622	broad.mit.edu	37	chr17	10360801	10360801	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcattgcagacttctggtaCagccccaccacagtctcatt	9	12	6	14	0	3	1	2	0	2	1	4	1	3	1	3	1	3	2	3	1	1	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:10360801C>A	uc002gmn.2	-	16	1944	c.1833G>T	c.(1831-1833)CTG>CTT	p.L611L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	611	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						ACTTCTGGTACAGCCCCACCA	0.507													25	33					1.1804e-14	1.38621e-14	1	0	A	10360801	A	A	10360801	2	1	81	1	0	0	0	0	0	0	0	1	10090	465	17	4		4	MYH4	17	10360801	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	56753	10360801	70834409	157	16224											
TEKT3	64518	broad.mit.edu	37	chr17	15231309	15231309	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatttcccccacatttacCgtcagcagttgtgcttcaac	8	13	6	14	1	2	0	2	0	0	0	3	0	3	0	3	0	5	4	3	0	2	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:15231309C>A	uc002gon.2	-	4	850	c.663G>T	c.(661-663)ACG>ACT	p.T221T		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	221					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		CCACATTTACCGTCAGCAGTT	0.388													127	72					3.47496e-60	4.32482e-60	1	0	A	15231309	A	A	15231309	2	1	81	1	0	0	0	0	0	0	0	1	15820	666	23	3		3	TEKT3	17	15231309	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	4870508	15231309	65963901	158	16225											
TRIM16	10626	broad.mit.edu	37	chr17	15532098	15532098	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtatcatactctacgccaTagaaggaaaggatccctccc	12	9	8	12	1	2	1	1	0	1	1	4	3	4	3	3	3	2	1	3	3	6	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:15532098T>C	uc002gox.2	-	9	2083	c.1526A>G	c.(1525-1527)TAT>TGT	p.Y509C	TRIM16_uc002gor.1_Intron|TRIM16_uc002gow.2_Missense_Mutation_p.Y293C|TRIM16_uc002goy.2_Missense_Mutation_p.Y379C	NM_006470	NP_006461	O95361	TRI16_HUMAN	tripartite motif-containing 16	509	B30.2/SPRY.				histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		CTCTACGCCATAGAAGGAAAG	0.517													27	158					0	0	0	0	C	15532098	C	C	15532098	3	2	81	1	0	0	0	0	1	0	0	0	16558	1406	49	5	172	5	TRIM16	17	15532098	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	300789	15532098	65663112	159	16226											
RFFL	117584	broad.mit.edu	37	chr17	33338994	33338994	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgatgcaagctctcaggacCggaagacatgcacagctcgg	11	5	12	13	3	1	1	1	0	1	1	3	4	1	3	2	3	4	4	2	3	2	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:33338994C>T	uc002hin.1	-	7	1258	c.1085G>A	c.(1084-1086)CGG>CAG	p.R362Q	RFFL_uc002hiq.2_Missense_Mutation_p.R271Q|RFFL_uc002him.1_Missense_Mutation_p.R354Q|RFFL_uc010cti.1_Missense_Mutation_p.R368Q|RFFL_uc002hip.1_Missense_Mutation_p.R326Q|RFFL_uc002hio.1_Missense_Mutation_p.R362Q	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	362					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CTCTCAGGACCGGAAGACATG	0.547													8	24					0	0	0	0	T	33338994	T	T	33338994	3	4	81	1	0	0	0	0	1	0	0	0	13315	652	23	1	10	1	RFFL	17	33338994	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	17806896	33338994	47856216	160	16227											
KCNH4	23415	broad.mit.edu	37	chr17	40322268	40322268	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgtgatgggccgcccaccGagccattgacatagggcacc	8	5	13	15	3	0	2	0	2	0	0	0	3	0	2	6	2	1	1	6	2	1	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:40322268G>A	uc002hzb.2	-	8	1580	c.1247C>T	c.(1246-1248)TCG>TTG	p.S416L		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	416	Extracellular (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GCCGCCCACCGAGCCATTGAC	0.632													9	8					0	0	0	0	A	40322268	A	A	40322268	3	1	81	1	0	0	0	0	1	0	0	0	8073	1059	37	1	1842	1	KCNH4	17	40322268	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	6983274	40322268	40872942	161	16228											
NGFR	4804	broad.mit.edu	37	chr17	47590198	47590198	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgagctgggctaccagcccGagcacatagactcctttacc	9	7	10	15	2	0	1	0	0	0	1	1	3	1	1	4	1	5	3	4	1	3	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:47590198G>A	uc002ioz.3	+	6	1236	c.1111G>A	c.(1111-1113)GAG>AAG	p.E371K		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	371	Cytoplasmic (Potential).|Death.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					CTACCAGCCCGAGCACATAGA	0.697													31	64					0	0	0	0	A	47590198	A	A	47590198	3	1	81	1	0	0	0	0	1	0	0	0	10450	1059	37	1	1133	1	NGFR	17	47590198	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	7267930	47590198	33605012	162	16229											
C17orf71	55181	broad.mit.edu	37	chr17	57292263	57292263	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggttttgagatttccttatgCatatgtgactgagagaggac	10	14	12	5	0	0	4	0	3	0	2	1	7	1	5	1	2	1	2	1	2	2	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:57292263C>G	uc002ixi.2	+	4	2918	c.2876C>G	c.(2875-2877)GCA>GGA	p.A959G		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	959					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					TTTCCTTATGCATATGTGACT	0.473													32	48					0	0	0	0	G	57292263	G	G	57292263	3	3	81	1	0	0	0	0	1	0	0	0	1885	710	25	4	2890	4	C17orf71	17	57292263	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	9702065	57292263	23902947	163	16230											
AXIN2	8313	broad.mit.edu	37	chr17	63532996	63532996	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcggtgtttacctatggggcTtgggcttgctctgccgctca	3	13	14	11	2	2	0	1	0	1	0	2	0	2	0	2	4	3	5	2	4	2	5			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:63532996T>A	uc002jfi.2	-	7	2187	c.1898A>T	c.(1897-1899)AAG>ATG	p.K633M	AXIN2_uc002jfh.2_Intron	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	633				Missing (in Ref. 2; AAF22799).	cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						CCTATGGGGCTTGGGCTTGCT	0.652									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				37	107					0	0	0	0	A	63532996	A	A	63532996	3	1	81	1	0	0	0	0	1	0	0	0	1239	1609	56	5	653	5	AXIN2	17	63532996	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	6240733	63532996	17662214	164	16231											
ITGB4	3691	broad.mit.edu	37	chr17	73751849	73751849	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctctgccctggggcccacAtctctcagagtgagctggca	6	10	11	14	0	3	2	1	1	2	1	5	2	3	2	2	3	2	2	2	3	0	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:73751849A>C	uc002jpg.2	+	35	4813	c.4626A>C	c.(4624-4626)ACA>ACC	p.T1542T	ITGB4_uc002jph.2_Silent_p.T1472T|ITGB4_uc002jpi.3_Silent_p.T1472T|ITGB4_uc002jpj.2_Silent_p.T1525T|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1542	Cytoplasmic (Potential).|Fibronectin type-III 3.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGGGGCCCACATCTCTCAGAG	0.677													10	44					0	0	0	0	C	73751849	C	C	73751849	2	2	81	1	0	0	0	0	0	0	0	1	7936	204	8	5		5	ITGB4	17	73751849	Silent	SNP	A	TCGA-CN-6024-01A-11D-1683-08	10218853	73751849	7443361	165	16232											
LGALS3BP	3959	broad.mit.edu	37	chr17	76967771	76967771	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctcttcgagctgttggtgtCcagggcactgggaatcgcag	6	10	15	10	2	1	0	0	0	1	0	4	2	2	1	1	3	1	5	1	3	1	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:76967771C>T	uc002jwh.2	-	6	1824	c.1645G>A	c.(1645-1647)GAC>AAC	p.D549N	LGALS3BP_uc002jwi.2_Missense_Mutation_p.D355N|LGALS3BP_uc010dhr.2_Missense_Mutation_p.D355N	NM_005567	NP_005558	Q08380	LG3BP_HUMAN	galectin 3 binding protein	549					cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			central_nervous_system(3)|ovary(1)	4			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			CTGTTGGTGTCCAGGGCACTG	0.607											OREG0024787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	56					0	0	0	0	T	76967771	T	T	76967771	3	4	81	1	0	0	0	0	1	0	0	0	8784	855	30	2	116	2	LGALS3BP	17	76967771	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	3215922	76967771	4227439	166	16233											
TMEM200C	645369	broad.mit.edu	37	chr18	5890315	5890324	+	Frame_Shift_Del	DEL	GGTGGCTCCT	-	-																															gctgaggttgctcggccgtgGgtggctcctggctggcaccc																										TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr18:5890315_5890324delGGTGGCTCCT	uc002kmx.1	-	1	1780_1789	c.1739_1748delAGGAGCCACC	c.(1738-1749)CAGGAGCCACCCfs	p.Q580fs		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	580_583						integral to membrane					0						CTCGGCCGTGGGTGGCTCCTGGCTGGCACC	0.6													---	---	---								-	5890324	-	-	5890315	7	5	81	1	0	1	0	1	0	0	0	0	16191	1232	43	0	121	0	TMEM200C	18	5890315	Frame_Shift_Del	DEL	GGTGGCTCCT	TCGA-CN-6024-01A-11D-1683-08		5890315	72186933	167	16234											
DTNA	1837	broad.mit.edu	37	chr18	32428278	32428278	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcatgcttgagagttcaaaCcggcttgatgaagaacacag	14	8	11	8	1	1	4	1	3	0	2	1	5	1	4	1	1	4	4	1	1	3	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr18:32428278C>A	uc010dmn.1	+	13	1285	c.1284C>A	c.(1282-1284)AAC>AAA	p.N428K	DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Missense_Mutation_p.N371K|DTNA_uc002kxw.2_Missense_Mutation_p.N371K|DTNA_uc010dmj.2_Missense_Mutation_p.N368K|DTNA_uc002kxz.2_Missense_Mutation_p.N368K|DTNA_uc002kxy.2_Missense_Mutation_p.N368K|DTNA_uc010dml.2_Missense_Mutation_p.N368K|DTNA_uc002kyb.3_Missense_Mutation_p.N425K|DTNA_uc010dmm.2_Missense_Mutation_p.N428K|DTNA_uc010xby.1_Missense_Mutation_p.N118K|DTNA_uc010dmo.2_Missense_Mutation_p.N50K|DTNA_uc002kyd.3_Missense_Mutation_p.N50K|DTNA_uc010xbz.1_Missense_Mutation_p.N137K|DTNA_uc010xca.1_Missense_Mutation_p.N80K|DTNA_uc002kye.2_Missense_Mutation_p.N76K	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	428	Syntrophin-binding region.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						AGAGTTCAAACCGGCTTGATG	0.448													19	14					4.35082e-09	4.83659e-09	1	0	A	32428278	A	A	32428278	3	1	81	1	0	0	0	0	1	0	0	0	4810	506	18	4	1369	4	DTNA	18	32428278	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	26537963	32428278	45648970	168	16235											
ADAMTSL5	339366	broad.mit.edu	37	chr19	1506029	1506029	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggggctcagccaggacagcgCcgggcagtcaggcgtatgcg	7	4	18	12	4	2	0	2	0	0	0	2	1	2	1	2	5	3	3	2	5	1	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:1506029C>T	uc002ltd.2	-	12	1845	c.1401G>A	c.(1399-1401)CGG>CGA	p.R467R	ADAMTSL5_uc010dsl.2_Silent_p.R236R|ADAMTSL5_uc010xgq.1_Silent_p.R477R	NM_213604	NP_998769	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5 precursor	467	NTR.					proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGACAGCGCCGGGCAGTCA	0.672													9	6					0	0	0	0	T	1506029	T	T	1506029	2	4	81	1	0	0	0	0	0	0	0	1	278	726	26	4		4	ADAMTSL5	19	1506029	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08		1506029	57622954	169	16236											
MUC16	94025	broad.mit.edu	37	chr19	9058238	9058238	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacacaggagaaagtgaggtCgtgagaggtaatgatgtcag	14	7	16	4	1	1	4	1	3	0	2	2	7	1	4	0	3	0	1	0	3	2	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:9058238C>A	uc002mkp.2	-	3	29412	c.29208G>T	c.(29206-29208)ACG>ACT	p.T9736T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9738	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAAGTGAGGTCGTGAGAGGTA	0.502													15	23					0.00244969	0.00256155	1	0	A	9058238	A	A	9058238	2	1	81	1	0	0	0	0	0	0	0	1	10026	871	31	3		3	MUC16	19	9058238	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	7552209	9058238	50070745	170	16237											
OR7D4	125958	broad.mit.edu	37	chr19	9324922	9324922	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccgtggccacatacaagaCaatgttattgaggagggtgt	11	10	13	7	1	0	2	0	1	0	1	0	3	0	3	2	3	2	1	2	3	4	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:9324922C>A	uc002mla.1	-	1	592	c.592G>T	c.(592-594)GTC>TTC	p.V198F		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						ACATACAAGACAATGTTATTG	0.522													14	85					6.31663e-08	6.95436e-08	1	0	A	9324922	A	A	9324922	3	1	81	1	0	0	0	0	1	0	0	0	11274	478	17	4	350	4	OR7D4	19	9324922	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	266684	9324922	49804061	171	16238											
SLC44A2	57153	broad.mit.edu	37	chr19	10738659	10738659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagccggggcgagttctgcgGgcagaagggcacaaaaaacg	12	3	16	10	4	1	1	0	0	1	1	1	2	1	1	1	4	3	3	1	4	4	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:10738659G>A	uc002mpf.2	+	4	363	c.224G>A	c.(223-225)GGG>GAG	p.G75E	SLC44A2_uc002mpe.3_Missense_Mutation_p.G73E	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	75	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GAGTTCTGCGGGCAGAAGGGC	0.572													12	12					0	0	0	0	A	10738659	A	A	10738659	3	1	81	1	0	0	0	0	1	0	0	0	14700	1232	43	4	273	4	SLC44A2	19	10738659	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	1413737	10738659	48390324	172	16239											
ZNF799	90576	broad.mit.edu	37	chr19	12501389	12501389	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagtttttttccagtgagtcTttttatgtctatgcaaggaa	9	18	9	5	0	2	1	0	1	2	0	3	3	3	2	1	1	1	2	1	1	4	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:12501389T>A	uc010dyt.2	-	4	1973	c.1823A>T	c.(1822-1824)AAG>ATG	p.K608M	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	608	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						CCAGTGAGTCTTTTTATGTCT	0.403													54	96					0	0	0	0	A	12501389	A	A	12501389	3	1	81	1	0	0	0	0	1	0	0	0	18233	1609	56	5	112	5	ZNF799	19	12501389	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	1762730	12501389	46627594	173	16240											
NOTCH3	4854	broad.mit.edu	37	chr19	15296203	15296204	+	Frame_Shift_Del	DEL	CA	-	-																															ggggccactccagccaggctCacacacacagcggaacctgg																										TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:15296203_15296204delCA	uc002nan.2	-	14	2236_2237	c.2160_2161delTG	c.(2158-2163)TGTGAGfs	p.C720fs	NOTCH3_uc002nao.1_Frame_Shift_Del_p.C720fs	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	720_721	Extracellular (Potential).|EGF-like 18.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CAGCCAGGCTCACACACACAGC	0.688													---	---	---								-	15296204	-	-	15296203	7	5	81	1	0	1	0	1	0	0	0	0	10604	835	29	0	4884	0	NOTCH3	19	15296203	Frame_Shift_Del	DEL	CA	TCGA-CN-6024-01A-11D-1683-08	2794814	15296203	43832780	174	16241											
UNC13A	23025	broad.mit.edu	37	chr19	17740103	17740103	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtccttggagatgatgtcTgcatactggaggagcacatt	11	11	12	7	0	1	2	0	1	1	1	2	5	2	4	1	3	3	2	1	3	2	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:17740103T>A	uc002nhd.2	-	31	3963	c.3963A>T	c.(3961-3963)GCA>GCT	p.A1321A		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1233	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						AGATGATGTCTGCATACTGGA	0.577													8	15					0	0	0	0	A	17740103	A	A	17740103	2	1	81	1	0	0	0	0	0	0	0	1	17052	1567	55	5		5	UNC13A	19	17740103	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	2443900	17740103	41388880	175	16242											
ZNF93	81931	broad.mit.edu	37	chr19	20044894	20044894	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atgtgaagaatgtggcaaagCcttcatttggtcctcagtcc	10	12	10	9	0	2	2	2	1	0	1	4	2	4	2	3	2	1	1	3	2	3	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:20044894C>T	uc002non.2	+	4	1241	c.1130C>T	c.(1129-1131)GCC>GTC	p.A377V		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	377	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						TGTGGCAAAGCCTTCATTTGG	0.393													26	42					0	0	0	0	T	20044894	T	T	20044894	3	4	81	1	0	0	0	0	1	0	0	0	18269	739	26	4	1144	4	ZNF93	19	20044894	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	2304791	20044894	39084089	176	16243											
ZNF829	374899	broad.mit.edu	37	chr19	37398928	37398928	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttagaattggaaagtccTgttcacaagaaaagacatgg	15	9	11	6	0	1	3	1	0	0	3	2	4	2	4	1	3	0	2	1	3	6	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:37398928T>C	uc002ofa.1	-	5	586	c.224_splice	c.e5-1	p.G75_splice	ZNF345_uc002oez.2_Intron|ZNF829_uc002ofb.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGGAAAGTCCTGTTCACAAGA	0.468													9	33					0	0	0	0	C	37398928	C	C	37398928	5	2	81	1	0	0	0	0	0	0	1	0	18249	1594	55	5	1084	5	ZNF829	19	37398928	Splice_Site	SNP	T	TCGA-CN-6024-01A-11D-1683-08	17354034	37398928	21730055	177	16244											
ZNF420	147923	broad.mit.edu	37	chr19	37618477	37618477	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatactggtgagaaaccctAtgcatgtaaggaatgtggga	13	10	12	6	0	1	1	1	1	0	1	1	4	1	3	1	3	3	2	1	3	5	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:37618477A>G	uc002ofl.2	+	5	799	c.584A>G	c.(583-585)TAT>TGT	p.Y195C		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	195	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAGAAACCCTATGCATGTAAG	0.388													13	37					0	0	0	0	G	37618477	G	G	37618477	3	3	81	1	0	0	0	0	1	0	0	0	17964	449	16	5	594	5	ZNF420	19	37618477	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	219549	37618477	21510506	178	16245											
MAP4K1	11184	broad.mit.edu	37	chr19	39103266	39103266	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctacctgagagggtgcacaTcaaagagcggtggctgtagc	10	7	14	10	1	1	2	1	1	0	2	1	3	1	2	2	3	4	3	2	3	3	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:39103266T>A	uc002oix.1	-	9	758	c.650A>T	c.(649-651)GAT>GTT	p.D217V	MAP4K1_uc002oiy.1_Missense_Mutation_p.D217V|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	217	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGGGTGCACATCAAAGAGCGG	0.627													22	31					0	0	0	0	A	39103266	A	A	39103266	3	1	81	1	0	0	0	0	1	0	0	0	9312	1435	50	5	2009	5	MAP4K1	19	39103266	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	1484789	39103266	20025717	179	16246											
ZNF180	7733	broad.mit.edu	37	chr19	44981291	44981291	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggataaatgatttcccacaTtgattacattcatagggctt	12	15	7	7	0	1	2	1	2	0	0	2	3	2	3	1	2	1	1	1	2	4	7			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:44981291T>A	uc002ozf.3	-	5	1689	c.1407A>T	c.(1405-1407)CAA>CAT	p.Q469H	ZNF180_uc002ozh.3_Missense_Mutation_p.Q126H|ZNF180_uc002ozi.3_Missense_Mutation_p.Q442H|ZNF180_uc002ozg.3_Missense_Mutation_p.Q468H|ZNF180_uc010ejm.2_Missense_Mutation_p.Q444H	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	469	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				ATTTCCCACATTGATTACATT	0.368													21	62					0	0	0	0	A	44981291	A	A	44981291	3	1	81	1	0	0	0	0	1	0	0	0	17815	1490	52	5	675	5	ZNF180	19	44981291	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08	5878025	44981291	14147692	180	16247											
PRKCG	5582	broad.mit.edu	37	chr19	54396287	54396287	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcgagtattacaatgtgccGgtggccgatgctgacaactg	9	9	14	9	3	0	1	0	1	0	0	0	3	0	1	2	3	4	2	2	3	4	2	rs139506301		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:54396287G>A	uc002qcq.1	+	8	1149	c.867G>A	c.(865-867)CCG>CCA	p.P289P	PRKCG_uc010eqz.1_Silent_p.P289P|PRKCG_uc010yef.1_Intron|PRKCG_uc010yeg.1_Silent_p.P289P|PRKCG_uc010yeh.1_Silent_p.P176P	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	289					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACAATGTGCCGGTGGCCGATG	0.607													4	23					0	0	0	0	A	54396287	A	A	54396287	2	1	81	1	0	0	0	0	0	0	0	1	12574	1103	39	1		1	PRKCG	19	54396287	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	9414996	54396287	4732696	181	16248											
ZNF71	58491	broad.mit.edu	37	chr19	57133988	57133988	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggtgcggccagtgcgggAagtccttcatcaagaactcc	10	7	12	12	2	2	1	2	0	0	1	4	2	4	2	3	3	3	0	3	3	3	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:57133988A>T	uc002qnm.3	+	3	1571	c.1333A>T	c.(1333-1335)AAG>TAG	p.K445*		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	445	C2H2-type 12.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		CCAGTGCGGGAAGTCCTTCAT	0.647													17	24					0	0	0	0	T	57133988	T	T	57133988	4	4	81	1	0	0	0	0	0	1	0	0	18181	247	9	5	1335	5	ZNF71	19	57133988	Nonsense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	2737701	57133988	1994995	182	16249											
SIGLEC1	6614	broad.mit.edu	37	chr20	3673192	3673192	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacttgcagggcagcaggacGggagctgcgggtgccctggg	6	5	20	10	2	0	0	0	0	0	0	0	3	0	2	1	5	5	4	1	5	0	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:3673192G>A	uc002wja.2	-	15	4006	c.4006C>T	c.(4006-4008)CGT>TGT	p.R1336C	SIGLEC1_uc002wjb.1_5'UTR|SIGLEC1_uc002wiz.3_Missense_Mutation_p.R1336C	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1336	Ig-like C2-type 13.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GCAGCAGGACGGGAGCTGCGG	0.682													5	14					0	0	0	0	A	3673192	A	A	3673192	3	1	81	1	0	0	0	0	1	0	0	0	14370	1116	39	1	1151	1	SIGLEC1	20	3673192	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08		3673192	59352328	183	16250											
C20orf103	24141	broad.mit.edu	37	chr20	9498787	9498787	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaaccatttcactggcctcTagtgatccgcagaagacggt	11	9	9	12	2	2	3	1	1	1	2	3	3	3	3	3	2	1	1	3	2	3	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:9498787T>C	uc002wni.1	+	5	805	c.576T>C	c.(574-576)TCT>TCC	p.S192S	C20orf103_uc010zrc.1_Silent_p.S148S	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	192	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			CACTGGCCTCTAGTGATCCGC	0.512													16	34					0	0	0	0	C	9498787	C	C	9498787	2	2	81	1	0	0	0	0	0	0	0	1	2085	1509	53	5		5	C20orf103	20	9498787	Silent	SNP	T	TCGA-CN-6024-01A-11D-1683-08	5825595	9498787	53526733	184	16251											
FOXA2	3170	broad.mit.edu	37	chr20	22563619	22563619	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gccatggcgcccgcgccgggGgacatccccgccagggacgg	5	2	17	17	6	0	0	0	0	0	0	1	2	1	2	6	5	0	0	6	5	0	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:22563619G>C	uc002wsn.2	-	3	433	c.243C>G	c.(241-243)TCC>TCG	p.S81S	FOXA2_uc002wsm.2_Silent_p.S87S	NM_153675	NP_710141	Q9Y261	FOXA2_HUMAN	forkhead box A2 isoform 2	81	Transactivation domain 1 (By similarity).				cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|kidney(1)|central_nervous_system(1)	4	Lung NSC(19;0.188)					CCGCGCCGGGGGACATCCCCG	0.766													19	37					0	0	0	0	C	22563619	C	C	22563619	2	2	81	1	0	0	0	0	0	0	0	1	6022	1219	43	4		4	FOXA2	20	22563619	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	13064832	22563619	40461901	185	16252											
CDK5RAP1	51654	broad.mit.edu	37	chr20	31967483	31967483	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acattctgaccaagaagtgtCacttctttcagcccctaaac	12	11	5	13	0	4	2	2	1	2	1	4	2	4	2	3	0	2	0	3	0	4	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:31967483C>T	uc010gek.2	-	9	1057	c.933G>A	c.(931-933)GTG>GTA	p.V311V	CDK5RAP1_uc002wyy.2_Silent_p.V207V|CDK5RAP1_uc002wyz.2_Silent_p.V297V|CDK5RAP1_uc002wza.2_Silent_p.V297V|CDK5RAP1_uc010gel.2_Silent_p.V206V|CDK5RAP1_uc010gem.2_Intron|CDK5RAP1_uc002wzc.1_Silent_p.V297V	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	311					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						CAAGAAGTGTCACTTCTTTCA	0.368													8	58					0	0	0	0	T	31967483	T	T	31967483	2	4	81	1	0	0	0	0	0	0	0	1	3160	813	29	2		2	CDK5RAP1	20	31967483	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	9403864	31967483	31058037	186	16253			1	19		2	2	16	C		9.835845e-05
CDK5RAP1	51654	broad.mit.edu	37	chr20	31967498	31967498	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtcacttctttcagcccCtaaacatgggaaaatatatt	13	13	6	9	0	3	0	2	0	1	0	3	1	3	1	2	1	2	0	2	1	6	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:31967498C>G	uc010gek.2	-	9	1043	c.919_splice	c.e9-1	p.G307_splice	CDK5RAP1_uc002wyy.2_Splice_Site_p.G203_splice|CDK5RAP1_uc002wyz.2_Splice_Site_p.G293_splice|CDK5RAP1_uc002wza.2_Splice_Site_p.G293_splice|CDK5RAP1_uc010gel.2_Splice_Site_p.G202_splice|CDK5RAP1_uc010gem.2_Intron|CDK5RAP1_uc002wzc.1_Splice_Site_p.G293_splice	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1						brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						CTTTCAGCCCCTAAACATGGG	0.343													7	51					0	0	0	0	G	31967498	G	G	31967498	5	3	81	1	0	0	0	0	0	0	1	0	3160	695	24	4	915	4	CDK5RAP1	20	31967498	Splice_Site	SNP	C	TCGA-CN-6024-01A-11D-1683-08	15	31967498	31058022	187	16254			1	19		2	2	16	C		9.835845e-05
GDF5	8200	broad.mit.edu	37	chr20	34021968	34021968	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggtgcgatgatccagtcGtcccagcccatgtccttgaa	8	9	12	12	2	0	2	0	2	0	0	4	3	3	2	4	2	2	0	4	2	1	1			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:34021968G>A	uc010gfc.1	-	2	1486	c.1245C>T	c.(1243-1245)GAC>GAT	p.D415D	uc002xcj.2_Missense_Mutation_p.V127I|GDF5_uc002xck.1_Silent_p.D415D|GDF5_uc010zvc.1_Silent_p.D415D	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	415					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			TGATCCAGTCGTCCCAGCCCA	0.607													128	58					0	0	0	0	A	34021968	A	A	34021968	2	1	81	1	0	0	0	0	0	0	0	1	6353	1136	40	1		1	GDF5	20	34021968	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	2054470	34021968	29003552	188	16255											
ZBTB46	140685	broad.mit.edu	37	chr20	62378483	62378483	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcctgggaacagcgcctctgGagagccctcgccgcctccgc	5	5	13	18	4	1	1	0	0	1	1	3	3	2	2	6	2	3	0	6	2	1	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:62378483G>C	uc002ygv.1	-	5	1771	c.1570C>G	c.(1570-1572)CCA>GCA	p.P524A	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					AGCGCCTCTGGAGAGCCCTCG	0.736													5	13					0	0	0	0	C	62378483	C	C	62378483	3	2	81	1	0	0	0	0	1	0	0	0	17614	1174	41	2	203	2	ZBTB46	20	62378483	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	28356515	62378483	647037	189	16256											
KRTAP15-1	254950	broad.mit.edu	37	chr21	31812926	31812926	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccagactaactacataagatCccttggatgtggaaacactg	14	9	8	10	0	0	2	0	0	0	2	1	4	1	4	2	2	3	0	2	2	4	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr21:31812926C>T	uc002yod.2	+	1	281	c.281C>T	c.(280-282)TCC>TTC	p.S94F		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	94						intermediate filament					0						TACATAAGATCCCTTGGATGT	0.502													12	86					0	0	0	0	T	31812926	T	T	31812926	3	4	81	1	0	0	0	0	1	0	0	0	8565	855	30	2	283	2	KRTAP15-1	21	31812926	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08		31812926	16316969	190	16257											
POFUT2	23275	broad.mit.edu	37	chr21	46685544	46685544	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttgagactgaggtgccaatAaaaaacctgcaaaggatcac	16	7	10	8	0	1	2	1	2	0	1	1	4	1	3	2	2	3	2	2	2	5	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr21:46685544A>G	uc002zhc.2	-	9	1168	c.1143T>C	c.(1141-1143)TTT>TTC	p.F381F	POFUT2_uc002zha.2_RNA|POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_3'UTR	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	381					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)		AGGTGCCAATAAAAAACCTGC	0.498													12	13					0	0	0	0	G	46685544	G	G	46685544	2	3	81	1	0	0	0	0	0	0	0	1	12239	359	13	5		5	POFUT2	21	46685544	Silent	SNP	A	TCGA-CN-6024-01A-11D-1683-08	14872618	46685544	1444351	191	16258											
MYO18B	84700	broad.mit.edu	37	chr22	26317306	26317306	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgttgtcagacgtgcagcTccttctgggcaccatggagg	7	10	13	11	1	2	1	1	0	1	1	3	2	3	2	2	3	2	4	2	3	0	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:26317306T>C	uc003abz.1	+	34	5697	c.5447T>C	c.(5446-5448)CTC>CCC	p.L1816P	MYO18B_uc003aca.1_Missense_Mutation_p.L1697P|MYO18B_uc010guy.1_Missense_Mutation_p.L1698P|MYO18B_uc010guz.1_Missense_Mutation_p.L1696P|MYO18B_uc011aka.1_Missense_Mutation_p.L970P|MYO18B_uc011akb.1_Missense_Mutation_p.L1329P	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1816	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GACGTGCAGCTCCTTCTGGGC	0.552													6	1					0	0	0	0	C	26317306	C	C	26317306	3	2	81	1	0	0	0	0	1	0	0	0	10119	1551	54	5	5577	5	MYO18B	22	26317306	Missense_Mutation	SNP	T	TCGA-CN-6024-01A-11D-1683-08		26317306	24987260	192	16259											
TPST2	8459	broad.mit.edu	37	chr22	26937142	26937142	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccttgttgcagagcacgcggGccggctctccgtgcttggca	4	9	14	14	4	1	1	0	0	1	1	2	1	1	1	3	3	3	6	3	3	0	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:26937142G>C	uc003acv.2	-	2	623	c.455C>G	c.(454-456)GCC>GGC	p.A152G	TPST2_uc003acw.2_Missense_Mutation_p.A152G|TPST2_uc003acx.2_Missense_Mutation_p.A152G|TPST2_uc011akf.1_Missense_Mutation_p.A152G	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	152	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						GAGCACGCGGGCCGGCTCTCC	0.637													26	47					0	0	0	0	C	26937142	C	C	26937142	3	2	81	1	0	0	0	0	1	0	0	0	16495	1203	42	4	694	4	TPST2	22	26937142	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	619836	26937142	24367424	193	16260											
KREMEN1	83999	broad.mit.edu	37	chr22	29490261	29490261	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctagagtgtttcacagccaAtggtgcggattataggggaa	11	11	13	6	1	2	1	1	0	1	1	2	3	2	3	1	4	2	1	1	4	5	4	rs35199515		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:29490261A>G	uc011akm.1	+	2	126	c.113A>G	c.(112-114)AAT>AGT	p.N38S	KREMEN1_uc003ael.2_Missense_Mutation_p.N38S|KREMEN1_uc011akn.1_5'UTR	NM_032045	NP_114434	Q96MU8	KREM1_HUMAN	kringle-containing transmembrane protein 1	36	Extracellular (Potential).|Kringle.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding			ovary(3)|lung(2)	5						TTCACAGCCAATGGTGCGGAT	0.428													36	56					0	0	0	0	G	29490261	G	G	29490261	3	3	81	1	0	0	0	0	1	0	0	0	8481	101	4	5	119	5	KREMEN1	22	29490261	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	2553119	29490261	21814305	194	16261											
SMCR7L	54471	broad.mit.edu	37	chr22	39908272	39908272	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggcccaagccagtggccAggaagggccaggtagacttg	9	4	15	13	1	0	1	0	0	0	1	0	2	0	2	5	5	1	1	5	5	3	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:39908272A>T	uc003axx.2	+	5	856	c.358A>T	c.(358-360)AGG>TGG	p.R120W	SMCR7L_uc003axw.2_Missense_Mutation_p.R120W|SMCR7L_uc010gxz.1_Intron|SMCR7L_uc003axy.2_Intron	NM_019008	NP_061881	Q9NQG6	SMC7L_HUMAN	hypothetical protein LOC54471	120						integral to membrane|mitochondrion				central_nervous_system(1)	1	Melanoma(58;0.04)					GCCAGTGGCCAGGAAGGGCCA	0.597													24	32					0	0	0	0	T	39908272	T	T	39908272	3	4	81	1	0	0	0	0	1	0	0	0	14855	179	7	5	368	5	SMCR7L	22	39908272	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	10418011	39908272	11396294	195	16262											
CACNA1I	8911	broad.mit.edu	37	chr22	40060149	40060149	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcacggccatcttcgtgggCgagatgacattgaaggtagc	9	10	13	9	3	2	3	1	2	1	1	3	4	2	3	1	3	1	1	1	3	2	4			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:40060149C>T	uc003ayc.2	+	20	3651	c.3651C>T	c.(3649-3651)GGC>GGT	p.G1217G	CACNA1I_uc003ayd.2_Silent_p.G1182G|CACNA1I_uc003aye.2_Silent_p.G1132G|CACNA1I_uc003ayf.2_Silent_p.G1097G	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1217	Helical; Name=S2 of repeat III; (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TCTTCGTGGGCGAGATGACAT	0.612													6	19					0	0	0	0	T	40060149	T	T	40060149	2	4	81	1	0	0	0	0	0	0	0	1	2558	755	27	1		1	CACNA1I	22	40060149	Silent	SNP	C	TCGA-CN-6024-01A-11D-1683-08	151877	40060149	11244417	196	16263											
ZC3H7B	23264	broad.mit.edu	37	chr22	41753426	41753426	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgctgccaccgccaccactgGggagtagggccaggtgttgg	6	7	16	12	1	0	0	0	0	0	0	0	1	0	1	5	5	2	3	5	5	1	2			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:41753426G>T	uc003azw.2	+	23	3143	c.2927G>T	c.(2926-2928)GGG>GTG	p.G976V	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	992					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						GCCACCACTGGGGAGTAGGGC	0.662													40	75					1.4709e-25	1.82074e-25	1	0	T	41753426	T	T	41753426	3	4	81	1	0	0	0	0	1	0	0	0	17640	1232	43	4	3013	4	ZC3H7B	22	41753426	Missense_Mutation	SNP	G	TCGA-CN-6024-01A-11D-1683-08	1693277	41753426	9551140	197	16264											
RS1	6247	broad.mit.edu	37	chrX	18660166	18660166	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccagcagctccatccggatGgcaatgcggacgtgccagcc	8	6	12	15	3	0	0	0	0	0	0	3	2	3	2	5	3	5	3	5	3	1	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:18660166G>A	uc004cyo.2	-	6	668	c.633C>T	c.(631-633)GCC>GCT	p.A211A	CDKL5_uc004cym.2_Intron|CDKL5_uc004cyn.2_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein	211	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					CCATCCGGATGGCAATGCGGA	0.677													34	10					0	0	0	0	A	18660166	A	A	18660166	2	1	81	1	0	0	0	0	0	0	0	1	13758	1335	47	4		4	RS1	23	18660166	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08		18660166	136610394	198	16265											
DMD	1756	broad.mit.edu	37	chrX	31227736	31227736	+	Frame_Shift_Del	DEL	G	-	-																															caaacaattaataatctgcaGgatatccatgggctggtcat																										TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:31227736delG	uc004dda.1	-	65	9686	c.9442delC	c.(9442-9444)CTGfs	p.L3148fs	DMD_uc004dcq.1_Frame_Shift_Del_p.L419fs|DMD_uc004dcr.1_Frame_Shift_Del_p.L688fs|DMD_uc004dcs.1_Frame_Shift_Del_p.L688fs|DMD_uc004dct.1_Frame_Shift_Del_p.L688fs|DMD_uc004dcu.1_Frame_Shift_Del_p.L688fs|DMD_uc004dcv.1_Frame_Shift_Del_p.L688fs|DMD_uc004dcw.2_Frame_Shift_Del_p.L1804fs|DMD_uc004dcx.2_Frame_Shift_Del_p.L1807fs|DMD_uc004dcz.2_Frame_Shift_Del_p.L3025fs|DMD_uc004dcy.1_Frame_Shift_Del_p.L3144fs|DMD_uc004ddb.1_Frame_Shift_Del_p.L3140fs|DMD_uc004dcm.1_Frame_Shift_Del_p.L80fs|DMD_uc004dcn.1_Frame_Shift_Del_p.L80fs|DMD_uc004dco.1_Frame_Shift_Del_p.L80fs|DMD_uc004dcp.1_Frame_Shift_Del_p.L80fs|DMD_uc011mkb.1_Frame_Shift_Del_p.L80fs|DMD_uc010ngm.2_Frame_Shift_Del_p.L80fs	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3148	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATAATCTGCAGGATATCCATG	0.448													---	---	---								-	31227736	-	-	31227736	7	5	81	1	0	1	0	1	0	0	0	0	4602	991	35	0	1765	0	DMD	23	31227736	Frame_Shift_Del	DEL	G	TCGA-CN-6024-01A-11D-1683-08	12567570	31227736	124042824	199	16266											
MTMR8	55613	broad.mit.edu	37	chrX	63445187	63445187	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagtccagatggccatgaCtgacagcagtgaaaagtggc	13	6	12	10	0	0	4	0	3	0	1	1	4	1	4	2	2	1	1	2	2	2	0			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:63445187C>G	uc011mou.1	-	10	1537	c.1469G>C	c.(1468-1470)AGT>ACT	p.S490T	ASB12_uc004dvp.1_Missense_Mutation_p.S106T|ASB12_uc004dvq.1_Missense_Mutation_p.S115T|ASB12_uc004dvr.1_Missense_Mutation_p.S115T	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	306	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						ATGGCCATGACTGACAGCAGT	0.527													7	5					0	0	0	0	G	63445187	G	G	63445187	3	3	81	1	0	0	0	0	1	0	0	0	10002	565	20	4		4	MTMR8	23	63445187	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	32217451	63445187	91825373	200	16267											
PHKA1	5255	broad.mit.edu	37	chrX	71887231	71887231	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccataatattttacctggcaGtgctgtacttcatcagccag	10	13	7	11	0	2	0	2	0	0	0	2	0	2	0	3	1	4	3	3	1	4	6			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:71887231G>A	uc004eax.3	-	7	1012	c.711C>T	c.(709-711)CAC>CAT	p.H237H	PHKA1_uc004eay.3_Silent_p.H237H|PHKA1_uc011mqi.1_Silent_p.H237H	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	237					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					TTACCTGGCAGTGCTGTACTT	0.423													18	7					0	0	0	0	A	71887231	A	A	71887231	2	1	81	1	0	0	0	0	0	0	0	1	11898	1020	36	4		4	PHKA1	23	71887231	Silent	SNP	G	TCGA-CN-6024-01A-11D-1683-08	8442044	71887231	83383329	201	16268											
IL1RAPL2	26280	broad.mit.edu	37	chrX	104512216	104512216	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagacgaacaactgaattgaAagttacaggtaggaatcagt	18	8	10	5	1	1	3	1	2	0	1	1	5	1	4	0	2	3	2	0	2	8	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:104512216A>C	uc004elz.1	+	5	1445	c.689A>C	c.(688-690)AAA>ACA	p.K230T		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	230	Ig-like C2-type 2.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						ACTGAATTGAAAGTTACAGGT	0.333													25	10					0	0	0	0	C	104512216	C	C	104512216	3	2	81	1	0	0	0	0	1	0	0	0	7701	14	1	5	703	5	IL1RAPL2	23	104512216	Missense_Mutation	SNP	A	TCGA-CN-6024-01A-11D-1683-08	32624985	104512216	50758344	202	16269											
COL4A6	1288	broad.mit.edu	37	chrX	107553986	107553986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taagcaacttactctcgctcCtttctcaggaaaacactgac	12	11	5	13	1	2	1	1	1	2	0	5	2	3	2	1	1	4	2	1	1	5	3			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:107553986C>T	uc004enw.3	-	3	242	c.139G>A	c.(139-141)GGA>AGA	p.G47R	COL4A6_uc004env.3_Missense_Mutation_p.G46R|COL4A6_uc011msn.1_Missense_Mutation_p.G46R|COL4A6_uc010npk.2_Missense_Mutation_p.G46R|COL4A6_uc004enx.2_RNA|COL4A6_uc004eny.2_RNA	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	47	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						ACTCTCGCTCCTTTCTCAGGA	0.383									Alport_syndrome_with_Diffuse_Leiomyomatosis				41	7					0	0	0	0	T	107553986	T	T	107553986	3	4	81	1	0	0	0	0	1	0	0	0	3710	690	24	4	5108	4	COL4A6	23	107553986	Missense_Mutation	SNP	C	TCGA-CN-6024-01A-11D-1683-08	3041770	107553986	47716574	203	16270											
CCDC27	148870	broad.mit.edu	37	chr1	3669095	3669095	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagccaggctgaagagagAtccacgggaaaagccgggcc	13	2	14	12	2	0	3	0	1	0	2	1	5	1	4	5	3	2	1	5	3	4	0			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:3669095A>G	uc001akv.2	+	1	131	c.50A>G	c.(49-51)GAT>GGT	p.D17G		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	17										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CTGAAGAGAGATCCACGGGAA	0.572													13	45					0	0	0	0	G	3669095	G	G	3669095	3	3	82	1	0	0	0	0	1	0	0	0	2814	333	12	5	52	5	CCDC27	1	3669095	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08		3669095	245581526	1	16271											
NBPF1	55672	broad.mit.edu	37	chr1	16891305	16891305	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caattgctgaaagttacctgGggcatggtgggttttgatct	8	14	13	6	0	1	2	0	2	1	0	1	2	1	2	1	4	2	4	1	4	3	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:16891305G>A	uc009vos.1	-	30	4286	c.3398C>T	c.(3397-3399)CCC>CTC	p.P1133L	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1133	NBPF 8.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AAGTTACCTGGGGCATGGTGG	0.254													8	521					0	0	0	0	A	16891305	A	A	16891305	3	1	82	1	0	0	0	0	1	0	0	0	10245	1232	43	4	254	4	NBPF1	1	16891305	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	13222210	16891305	232359316	2	16272											
FOXJ3	22887	broad.mit.edu	37	chr1	42660589	42660589	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaagtgactgctcaaaaacTgacttataaaggctccgaaa	16	9	7	9	1	1	2	1	2	0	0	2	3	2	2	1	1	2	2	1	1	7	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:42660589T>G	uc001che.2	-	10	1218	c.906A>C	c.(904-906)TCA>TCC	p.S302S	FOXJ3_uc001chf.2_Silent_p.S302S|FOXJ3_uc001chg.2_Silent_p.S302S|FOXJ3_uc001chh.1_Silent_p.S268S	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	302					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCTCAAAAACTGACTTATAAA	0.323													47	100					0	0	0	0	G	42660589	G	G	42660589	2	3	82	1	0	0	0	0	0	0	0	1	6047	1567	55	5		5	FOXJ3	1	42660589	Silent	SNP	T	TCGA-CN-6988-01A-11D-1912-08	25769284	42660589	206590032	3	16273											
SLC35D1	23169	broad.mit.edu	37	chr1	67518538	67518538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaactgccactgtggccacCatctgtaaacaagagaacac	15	6	8	12	0	1	2	0	0	1	2	1	3	1	2	3	1	4	1	3	1	5	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:67518538C>T	uc001ddk.2	-	3	624	c.240G>A	c.(238-240)ATG>ATA	p.M80I	SLC35D1_uc010oph.1_Missense_Mutation_p.M1I	NM_015139	NP_055954	Q9NTN3	S35D1_HUMAN	solute carrier family 35 (UDP-glucuronic	80	Helical; (Potential).				chondroitin sulfate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity				0					Lorazepam(DB00186)	CTGTGGCCACCATCTGTAAAC	0.433													25	68					0	0	0	0	T	67518538	T	T	67518538	3	4	82	1	0	0	0	0	1	0	0	0	14645	594	21	4	867	4	SLC35D1	1	67518538	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	24857949	67518538	181732083	4	16274											
COL24A1	255631	broad.mit.edu	37	chr1	86200620	86200620	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtaaatgaaggaagttcaTctggactttcccaactccaa	14	10	7	10	0	2	1	1	1	1	0	4	3	4	3	2	2	1	2	2	2	6	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:86200620T>C	uc001dlj.2	-	59	4852	c.4810A>G	c.(4810-4812)ATG>GTG	p.M1604V	COL24A1_uc001dli.2_Missense_Mutation_p.M719V|COL24A1_uc010osd.1_Missense_Mutation_p.M904V|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1604	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		AGGAAGTTCATCTGGACTTTC	0.433													16	38					0	0	0	0	C	86200620	C	C	86200620	3	2	82	1	0	0	0	0	1	0	0	0	3698	1435	50	5	342	5	COL24A1	1	86200620	Missense_Mutation	SNP	T	TCGA-CN-6988-01A-11D-1912-08	18682082	86200620	163050001	5	16275											
MTF2	22823	broad.mit.edu	37	chr1	93602558	93602558	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaaaggtgcagtatcttgtgGaatgggaaggagcaactgca	13	8	15	5	0	1	0	0	0	1	0	1	4	1	3	0	4	4	4	0	4	5	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:93602558G>C	uc009wdj.2	+	15	2048	c.1756G>C	c.(1756-1758)GAA>CAA	p.E586Q	MTF2_uc010oth.1_Missense_Mutation_p.E484Q|MTF2_uc009wdk.2_Missense_Mutation_p.E529Q|MTF2_uc001dpi.3_Missense_Mutation_p.E313Q|MTF2_uc010oti.1_Missense_Mutation_p.E484Q|MTF2_uc001dpj.3_Missense_Mutation_p.E484Q|MTF2_uc001dpl.3_Missense_Mutation_p.E484Q|MTF2_uc001dpm.3_Missense_Mutation_p.E255Q	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	586						nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		GTATCTTGTGGAATGGGAAGG	0.458													18	35					0	0	0	0	C	93602558	C	C	93602558	3	2	82	1	0	0	0	0	1	0	0	0	9976	1175	41	2	1814	2	MTF2	1	93602558	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	7401938	93602558	155648063	6	16276											
SLC16A1	6566	broad.mit.edu	37	chr1	113460045	113460045	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgcaaagaaatactgaattCgaggtcttattggctttgtg	11	13	10	7	2	1	2	0	1	1	1	2	3	1	2	1	2	1	2	1	2	5	5			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:113460045C>T	uc001ecx.2	-	4	1815	c.983G>A	c.(982-984)CGA>CAA	p.R328Q	SLC16A1_uc001ecy.2_Missense_Mutation_p.R328Q|SLC16A1_uc001ecz.2_Missense_Mutation_p.R328Q	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	328	Cytoplasmic (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	ATACTGAATTCGAGGTCTTAT	0.453													8	24					0	0	0	0	T	113460045	T	T	113460045	3	4	82	1	0	0	0	0	1	0	0	0	14467	884	31	1	527	1	SLC16A1	1	113460045	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	19857487	113460045	135790576	7	16277											
PIP5K1A	8394	broad.mit.edu	37	chr1	151206795	151206795	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaccaagatcggtaaaaatGcatatcaaatatgacctcaa	18	10	5	8	1	2	2	2	1	0	1	3	2	2	2	2	1	2	2	2	1	9	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:151206795G>A	uc001exj.2	+	8	1214	c.762G>A	c.(760-762)ATG>ATA	p.M254I	PIP5K1A_uc001exi.2_Missense_Mutation_p.M241I|PIP5K1A_uc010pcu.1_Missense_Mutation_p.M242I|PIP5K1A_uc001exk.2_Missense_Mutation_p.M241I|PIP5K1A_uc010pcv.1_Missense_Mutation_p.M11I	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	254	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			CGGTAAAAATGCATATCAAAT	0.443													17	50					0	0	0	0	A	151206795	A	A	151206795	3	1	82	1	0	0	0	0	1	0	0	0	11994	1319	46	4	792	4	PIP5K1A	1	151206795	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	37746750	151206795	98043826	8	16278											
PGLYRP4	57115	broad.mit.edu	37	chr1	153318647	153318647	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatacctgtttagcttgtgTtttgttccaggaggaatcac	8	16	10	7	0	1	1	1	1	0	0	2	3	2	3	2	2	2	4	2	2	3	7			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:153318647T>C	uc001fbo.2	-	3	135	c.70A>G	c.(70-72)ACA>GCA	p.T24A	PGLYRP4_uc001fbp.2_Missense_Mutation_p.T24A	NM_020393	NP_065126	Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein-I-beta	24					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)|skin(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTAGCTTGTGTTTTGTTCCAG	0.463													100	73					0	0	0	0	C	153318647	C	C	153318647	3	2	82	1	0	0	0	0	1	0	0	0	11851	1725	60	5	1079	5	PGLYRP4	1	153318647	Missense_Mutation	SNP	T	TCGA-CN-6988-01A-11D-1912-08	2111852	153318647	95931974	9	16279											
C1orf104	284618	broad.mit.edu	37	chr1	155290743	155290743	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggggaccgtgggagccgCggacaagcccaaggccggag	8	1	20	12	5	0	0	0	0	0	0	0	4	0	4	4	7	2	0	4	7	2	0			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:155290743C>T	uc001fki.2	-	2	814	c.537G>A	c.(535-537)CCG>CCA	p.P179P	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_Intron|RUSC1_uc001fkj.2_5'UTR|RUSC1_uc001fkk.2_5'UTR|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank	NM_001039517	NP_001034606	Q66K80	RUAS1_HUMAN	hypothetical protein LOC284618	179											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.32e-10)|all cancers(21;3.51e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			GTGGGAGCCGCGGACAAGCCC	0.731													11	16					0	0	0	0	T	155290743	T	T	155290743	2	4	82	1	0	0	0	0	0	0	0	1	1987	755	27	1		1	C1orf104	1	155290743	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	1972096	155290743	93959878	10	16280											
FCGR3A	2214	broad.mit.edu	37	chr1	161518311	161518311	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggcagcgtcaatgaagtaGctcgaggcctggcttgagat	9	9	15	8	2	1	2	1	2	0	1	2	4	1	2	1	3	2	4	1	3	3	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:161518311G>T	uc001gat.3	-	4	356	c.219C>A	c.(217-219)AGC>AGA	p.S73R	FCGR3A_uc001gar.2_Missense_Mutation_p.S109R|FCGR3A_uc001gas.2_Missense_Mutation_p.S108R|FCGR3A_uc009wuh.2_Missense_Mutation_p.S72R|FCGR3A_uc009wui.2_Missense_Mutation_p.S73R	NM_001127595	NP_001121067	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor	73	Ig-like C2-type 1.|Extracellular (Potential).				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CAATGAAGTAGCTCGAGGCCT	0.552													62	249					3.57465e-26	1.68176e-25	1	0	T	161518311	T	T	161518311	3	4	82	1	0	0	0	0	1	0	0	0	5816	962	34	4	557	4	FCGR3A	1	161518311	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	6227568	161518311	87732310	11	16281											
ATF6	22926	broad.mit.edu	37	chr1	161736177	161736177	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccggctggggttgccggCaccatggagtcaccttttag	6	9	15	11	2	1	0	1	0	0	0	1	2	1	1	4	5	2	3	4	5	1	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:161736177C>A	uc001gbr.2	+	1	94	c.27C>A	c.(25-27)GGC>GGA	p.G9G	ATF6_uc001gbq.1_Silent_p.G9G	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	9	Cytoplasmic (Potential).|Transcription activation.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GGGTTGCCGGCACCATGGAGT	0.582													11	52					3.07112e-06	1.17642e-05	1	0	A	161736177	A	A	161736177	2	1	82	1	0	0	0	0	0	0	0	1	1086	697	25	4		4	ATF6	1	161736177	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	217866	161736177	87514444	12	16282											
NME7	29922	broad.mit.edu	37	chr1	169138773	169138773	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctctgagagttccagggCgtaaatgccgggcaatttcc	8	11	12	10	2	1	1	0	1	1	1	3	2	3	1	3	2	2	4	3	2	3	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:169138773C>A	uc001gfu.2	-	11	1248	c.1010G>T	c.(1009-1011)CGC>CTC	p.R337L	NME7_uc010plq.1_RNA|NME7_uc001gft.2_Missense_Mutation_p.R301L	NM_013330	NP_037462	Q9Y5B8	NDK7_HUMAN	nucleoside diphosphate kinase 7 isoform a	337					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)	1	all_hematologic(923;0.208)					AGTTCCAGGGCGTAAATGCCG	0.363													44	164					8.00217e-19	3.59585e-18	1	0	A	169138773	A	A	169138773	3	1	82	1	0	0	0	0	1	0	0	0	10550	768	27	3	128	3	NME7	1	169138773	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	7402596	169138773	80111848	13	16283											
RC3H1	149041	broad.mit.edu	37	chr1	173952661	173952661	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctctgtaactgttcgttCacctaaagatcgagctgccc	9	11	9	12	2	2	1	1	0	1	1	4	3	2	1	2	0	4	5	2	0	3	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:173952661C>A	uc001gju.3	-	3	574	c.487G>T	c.(487-489)GAA>TAA	p.E163*	RC3H1_uc010pms.1_Nonsense_Mutation_p.E163*|RC3H1_uc001gjv.2_Nonsense_Mutation_p.E163*|RC3H1_uc010pmt.1_Nonsense_Mutation_p.E163*	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	163					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						ACTGTTCGTTCACCTAAAGAT	0.512													35	40					2.42023e-17	1.06703e-16	1	0	A	173952661	A	A	173952661	4	1	82	1	0	0	0	0	0	1	0	0	13231	835	29	2	2982	2	RC3H1	1	173952661	Nonsense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	4813888	173952661	75297960	14	16284											
CR1	1378	broad.mit.edu	37	chr1	207751508	207751508	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgccgtgtgaagtgccaggcCctgaacaaatgggagccaga	11	5	14	11	2	0	3	0	2	0	1	0	4	0	4	4	2	3	0	4	2	3	0			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:207751508C>A	uc001hfy.2	+	21	3686	c.3546C>A	c.(3544-3546)GCC>GCA	p.A1182A	CR1_uc009xcl.1_Silent_p.A732A|CR1_uc001hfx.2_Silent_p.A1632A	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1182	Extracellular (Potential).|Sushi 18.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						AGTGCCAGGCCCTGAACAAAT	0.512													31	79					4.92203e-23	2.28499e-22	1	0	A	207751508	A	A	207751508	2	1	82	1	0	0	0	0	0	0	0	1	3855	610	22	4		4	CR1	1	207751508	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	33798847	207751508	41499113	15	16285											
PROX1	5629	broad.mit.edu	37	chr1	214184944	214184944	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacattcagatggagaagtaCgcacgtcaagccatcaacga	15	7	9	10	3	3	2	3	0	0	2	3	4	3	2	1	1	4	2	1	1	5	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:214184944C>G	uc001hkh.2	+	4	2186	c.1914C>G	c.(1912-1914)TAC>TAG	p.Y638*		NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	638	Prospero-like.				aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TGGAGAAGTACGCACGTCAAG	0.423													44	23					0	0	0	0	G	214184944	G	G	214184944	4	3	82	1	0	0	0	0	0	1	0	0	12622	547	19	3	1924	3	PROX1	1	214184944	Nonsense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	6433436	214184944	35065677	16	16286											
RYR2	6262	broad.mit.edu	37	chr1	237540685	237540685	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatcagaaggagaaaaagtaCgagttggagatgacctcatc	16	7	12	6	1	2	4	2	1	0	3	3	8	2	4	1	2	1	2	1	2	4	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:237540685C>G	uc001hyl.1	+	8	646	c.526C>G	c.(526-528)CGA>GGA	p.R176G		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	176	Cytoplasmic (By similarity).|MIR 2.		R -> Q (in ARVD2 and CPVT1).		cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGAAAAAGTACGAGTTGGAGA	0.443													4	24					0	0	0	0	G	237540685	G	G	237540685	3	3	82	1	0	0	0	0	1	0	0	0	13834	528	19	3	556	3	RYR2	1	237540685	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	23355741	237540685	11709936	17	16287											
TFB2M	64216	broad.mit.edu	37	chr1	246729395	246729395	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgaccagcgcccgccaaggCggagagcctcagccgccgag	8	1	15	17	6	1	1	1	0	0	1	1	4	1	1	6	2	3	0	6	2	1	0	rs143392079	byFrequency	TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr1:246729395C>A	uc001ibn.2	-	1	171	c.46G>T	c.(46-48)GCC>TCC	p.A16S	CNST_uc001ibo.3_5'Flank|CNST_uc001ibp.2_5'Flank|TFB2M_uc010pys.1_RNA	NM_022366	NP_071761	Q9H5Q4	TFB2M_HUMAN	transcription factor B2, mitochondrial	16					positive regulation of transcription, DNA-dependent|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity			ovary(1)	1	all_cancers(71;4.25e-05)|all_epithelial(71;4.92e-06)|Ovarian(71;0.0254)|all_lung(81;0.0272)|Breast(184;0.0318)|Lung NSC(105;0.0376)		OV - Ovarian serous cystadenocarcinoma(106;0.00358)			CCCGCCAAGGCGGAGAGCCTC	0.602													21	22					1.5548e-18	6.94213e-18	1	0	A	246729395	A	A	246729395	3	1	82	1	0	0	0	0	1	0	0	0	15860	768	27	3	1176	3	TFB2M	1	246729395	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	9188710	246729395	2521226	18	16288											
COLEC11	78989	broad.mit.edu	37	chr2	3691061	3691061	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgtgagtgcagccagctgcGcaaggccatcggggagatgg	9	6	17	9	2	0	2	0	1	0	1	1	3	0	2	2	4	4	3	2	4	1	0			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:3691061G>A	uc002qya.2	+	6	504	c.356G>A	c.(355-357)CGC>CAC	p.R119H	COLEC11_uc002qxz.2_Missense_Mutation_p.R116H|COLEC11_uc002qyb.2_Missense_Mutation_p.R95H|COLEC11_uc002qyc.2_Missense_Mutation_p.R95H|COLEC11_uc010ewo.2_Missense_Mutation_p.R71H|COLEC11_uc010ewp.2_Missense_Mutation_p.R93H|COLEC11_uc010ewq.2_Missense_Mutation_p.R69H|COLEC11_uc010ewr.2_Missense_Mutation_p.R69H|COLEC11_uc010ews.2_Missense_Mutation_p.R45H	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	119	Potential.					collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		AGCCAGCTGCGCAAGGCCATC	0.637													34	56					0	0	0	0	A	3691061	A	A	3691061	3	1	82	1	0	0	0	0	1	0	0	0	3726	1087	38	1	457	1	COLEC11	2	3691061	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08		3691061	239508312	19	16289											
CYP1B1	1545	broad.mit.edu	37	chr2	38301665	38301665	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaggcgtccatcatgtcgcgGggggcggccccgggccgaag	6	4	18	13	6	1	0	1	0	0	0	3	1	2	0	4	6	0	0	4	6	2	0			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:38301665G>A	uc002rqo.2	-	3	1270	c.867C>T	c.(865-867)CCC>CCT	p.P289P		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	289					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	TCATGTcgcggggggcggccc	0.512													19	9					0	0	0	0	A	38301665	A	A	38301665	2	1	82	1	0	0	0	0	0	0	0	1	4168	1219	43	4		4	CYP1B1	2	38301665	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	34610604	38301665	204897708	20	16290											
DCTN1	1639	broad.mit.edu	37	chr2	74607154	74607154	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctgtacacgtgcctcttgCtctgtgccatgttgctcacc	4	13	10	14	1	3	0	1	0	2	0	3	0	3	0	3	1	5	5	3	1	1	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:74607154C>A	uc002skx.2	-	1	322	c.11G>T	c.(10-12)AGC>ATC	p.S4I	DCTN1_uc002skw.1_5'Flank|DCTN1_uc010ffd.2_Missense_Mutation_p.S4I|DCTN1_uc002sky.2_Intron	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	4					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						GTGCCTCTTGCTCTGTGCCAT	0.627													24	14					3.28513e-13	1.40419e-12	1	0	A	74607154	A	A	74607154	3	1	82	1	0	0	0	0	1	0	0	0	4323	797	28	4	3965	4	DCTN1	2	74607154	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	36305489	74607154	168592219	21	16291											
LRRTM4	80059	broad.mit.edu	37	chr2	77745732	77745732	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcaataattttgtgaaaTgaaacatgctcatactcttg	13	13	7	8	1	2	2	1	2	1	0	2	2	2	2	1	1	3	2	1	1	5	5			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:77745732T>C	uc002snr.2	-	3	1678	c.1263A>G	c.(1261-1263)TCA>TCG	p.S421S	LRRTM4_uc002snq.2_Silent_p.S421S|LRRTM4_uc002sns.2_Silent_p.S421S|LRRTM4_uc002snt.2_Silent_p.S422S	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	421	Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		TTTTGTGAAATGAAACATGCT	0.493													45	83					0	0	0	0	C	77745732	C	C	77745732	2	2	82	1	0	0	0	0	0	0	0	1	9092	1451	51	5		5	LRRTM4	2	77745732	Silent	SNP	T	TCGA-CN-6988-01A-11D-1912-08	3138578	77745732	165453641	22	16292											
LRRTM4	80059	broad.mit.edu	37	chr2	77746588	77746588	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtaggagaggtccagattgCggagattgggaactgggtga	10	9	18	4	1	0	4	0	1	0	3	1	7	1	5	1	5	2	1	1	5	2	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:77746588C>T	uc002snr.2	-	3	822	c.407G>A	c.(406-408)CGC>CAC	p.R136H	LRRTM4_uc002snq.2_Missense_Mutation_p.R136H|LRRTM4_uc002sns.2_Missense_Mutation_p.R136H|LRRTM4_uc002snt.2_Missense_Mutation_p.R137H	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	136	LRR 4.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GTCCAGATTGCGGAGATTGGG	0.383													48	43					0	0	0	0	T	77746588	T	T	77746588	3	4	82	1	0	0	0	0	1	0	0	0	9092	768	27	1	1379	1	LRRTM4	2	77746588	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	856	77746588	165452785	23	16293											
REG1B	5968	broad.mit.edu	37	chr2	79313964	79313964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaacccaggtctcagggtCttcattaaagtagtagcagt	12	11	9	9	0	4	0	3	0	2	0	5	0	4	0	1	2	2	3	1	2	5	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:79313964C>T	uc002sny.2	-	3	269	c.157G>A	c.(157-159)GAC>AAC	p.D53N	REG1B_uc010ffv.1_Missense_Mutation_p.D53N|REG1B_uc010ffw.2_Missense_Mutation_p.D53N	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	53	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						GTCTCAGGGTCTTCATTAAAG	0.537													29	184					0	0	0	0	T	79313964	T	T	79313964	3	4	82	1	0	0	0	0	1	0	0	0	13276	913	32	2	359	2	REG1B	2	79313964	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	1567376	79313964	163885409	24	16294											
NPAS2	4862	broad.mit.edu	37	chr2	101607326	101607326	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaagtcagcaggacgggacgGcaagtcaagtacgtggaccc	12	4	15	10	3	2	0	2	0	0	0	2	4	2	3	1	4	2	3	1	4	4	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:101607326G>A	uc002tap.1	+	19	2389	c.2103G>A	c.(2101-2103)CGG>CGA	p.R701R	NPAS2_uc010yvt.1_Silent_p.R766R|NPAS2_uc010fit.1_Intron	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	701					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						GGACGGGACGGCAAGTCAAGT	0.647													38	12					0	0	0	0	A	101607326	A	A	101607326	2	1	82	1	0	0	0	0	0	0	0	1	10617	1190	42	4		4	NPAS2	2	101607326	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	22293362	101607326	141592047	25	16295											
POTEF	728378	broad.mit.edu	37	chr2	130872899	130872899	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggccagatgtagagcaGtcctatgagagtgagaagac	14	6	14	7	0	0	6	0	2	0	6	1	8	1	6	2	1	1	2	2	1	3	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:130872899G>T	uc010fmh.2	-	4	924	c.524C>A	c.(523-525)ACT>AAT	p.T175N		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	175	ANK 1.					cell cortex	ATP binding			skin(3)|ovary(2)	5						ATGTAGAGCAGTCCTATGAGA	0.418													30	96					4.42602e-33	2.11064e-32	1	0	T	130872899	T	T	130872899	3	4	82	1	0	0	0	0	1	0	0	0	12320	1029	36	4	2759	4	POTEF	2	130872899	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	29265573	130872899	112326474	26	16296											
ZEB2	9839	broad.mit.edu	37	chr2	145147514	145147514	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	actgatagggcttctcgcccGagtgaagccttgagtgctcg	7	10	13	11	3	1	3	0	3	1	0	3	4	1	3	2	1	2	2	2	1	2	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:145147514G>C	uc002tvu.2	-	10	3629	c.3149C>G	c.(3148-3150)TCG>TGG	p.S1050W	ZEB2_uc002tvv.2_Missense_Mutation_p.S1044W|ZEB2_uc010zbm.1_Missense_Mutation_p.S1021W|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	1050						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTTCTCGCCCGAGTGAAGCCT	0.483													5	60					0	0	0	0	C	145147514	C	C	145147514	3	2	82	1	0	0	0	0	1	0	0	0	17691	1059	37	3	499	3	ZEB2	2	145147514	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	14274615	145147514	98051859	27	16297											
TTN	7273	broad.mit.edu	37	chr2	179532239	179532239	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttctggaacaactttcttGggtggctcaggcacttaaaa	10	13	9	9	0	4	0	1	0	3	0	4	1	4	1	0	4	2	2	0	4	4	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:179532239G>C	uc010zfk.1	-	7	713	c.165C>G	c.(163-165)CCC>CCG	p.P55P	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	11249							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAACTTTCTTGGGTGGCTCAG	0.308													13	13					0	0	0	0	C	179532239	C	C	179532239	2	2	82	1	0	0	0	0	0	0	0	1	16803	1363	47	4		4	TTN	2	179532239	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	34384725	179532239	63667134	28	16298											
TTN	7273	broad.mit.edu	37	chr2	179664292	179664292	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcgatggggactgctgcCgagccagctgtgctttggca	5	9	17	10	2	0	0	0	0	0	0	0	3	0	1	2	4	5	4	2	4	0	1	rs151174349		TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:179664292C>T	uc002und.2	-	6	1061	c.836G>A	c.(835-837)CGG>CAG	p.R279Q	TTN_uc010zfg.1_Missense_Mutation_p.R279Q|TTN_uc010zfh.1_Missense_Mutation_p.R279Q|TTN_uc010zfi.1_Missense_Mutation_p.R279Q|TTN_uc010zfj.1_Missense_Mutation_p.R279Q|TTN_uc002unb.2_Missense_Mutation_p.R279Q			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	279							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGACTGCTGCCGAGCCAGCTG	0.592													15	44					0	0	0	0	T	179664292	T	T	179664292	3	4	82	1	0	0	0	0	1	0	0	0	16803	652	23	1	110580	1	TTN	2	179664292	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	132053	179664292	63535081	29	16299											
FRZB	2487	broad.mit.edu	37	chr2	183699618	183699618	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgagttcctgccagacttCtgactctgagtggaatcact	8	13	9	11	1	3	3	1	2	2	1	5	5	4	4	2	1	1	1	2	1	1	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:183699618C>A	uc002upa.1	-	6	1154	c.936G>T	c.(934-936)CAG>CAT	p.Q312H		NM_001463	NP_001454	Q92765	SFRP3_HUMAN	frizzled-related protein precursor	312	Ser-rich.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			TGCCAGACTTCTGACTCTGAG	0.413													34	25					1.21669e-08	4.98772e-08	1	0	A	183699618	A	A	183699618	3	1	82	1	0	0	0	0	1	0	0	0	6099	912	32	2	45	2	FRZB	2	183699618	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	4035326	183699618	59499755	30	16300											
AOX1	316	broad.mit.edu	37	chr2	201460091	201460091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccatcaccaagaggataaGgtaccgtgcagcaaagtcca	14	5	9	13	1	1	1	1	0	0	1	2	2	2	2	5	2	3	3	5	2	4	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:201460091G>A	uc002uvx.2	+	3	301	c.200G>A	c.(199-201)AGG>AAG	p.R67K		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	67	2Fe-2S ferredoxin-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	AAGAGGATAAGGTACCGTGCA	0.338													18	16					0	0	0	0	A	201460091	A	A	201460091	3	1	82	1	0	0	0	0	1	0	0	0	729	1014	35	4	210	4	AOX1	2	201460091	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	17760473	201460091	41739282	31	16301											
ERBB4	2066	broad.mit.edu	37	chr2	212251600	212251600	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtttgggtttgtctcgcatAggagtcatgtaaccttcctc	6	16	10	9	1	2	0	1	0	1	0	5	1	3	1	2	2	1	4	2	2	2	5			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:212251600A>C	uc002veg.1	-	27	3557	c.3459T>G	c.(3457-3459)CCT>CCG	p.P1153P	ERBB4_uc002veh.1_Silent_p.P1137P|ERBB4_uc010zji.1_Silent_p.P1143P|ERBB4_uc010zjj.1_Silent_p.P1127P	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1153	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TGTCTCGCATAGGAGTCATGT	0.468										TSP Lung(8;0.080)			35	28					0	0	0	0	C	212251600	C	C	212251600	2	2	82	1	0	0	0	0	0	0	0	1	5233	407	15	5		5	ERBB4	2	212251600	Silent	SNP	A	TCGA-CN-6988-01A-11D-1912-08	10791509	212251600	30947773	32	16302											
ERBB4	2066	broad.mit.edu	37	chr2	212543814	212543814	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agactctatgcagatccttcCtctactgaagcggcgacacg	10	9	9	13	3	2	3	0	1	2	2	4	4	4	3	2	1	3	1	2	1	3	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:212543814C>A	uc002veg.1	-	13	1683	c.1585G>T	c.(1585-1587)GGA>TGA	p.G529*	ERBB4_uc002veh.1_Nonsense_Mutation_p.G529*|ERBB4_uc010zji.1_Nonsense_Mutation_p.G529*|ERBB4_uc010zjj.1_Nonsense_Mutation_p.G529*|ERBB4_uc010fut.1_Nonsense_Mutation_p.G529*	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	529	Extracellular (Potential).|Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CAGATCCTTCCTCTACTGAAG	0.498										TSP Lung(8;0.080)			8	22					0.000157383	0.000593149	1	0	A	212543814	A	A	212543814	4	1	82	1	0	0	0	0	0	1	0	0	5233	690	24	4	2405	4	ERBB4	2	212543814	Nonsense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	292214	212543814	30655559	33	16303											
STK36	27148	broad.mit.edu	37	chr2	219553529	219553529	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccttgtattccttctgccGggaggcagggcttcctgggc	3	12	14	12	1	1	0	0	0	1	0	3	1	3	1	4	4	2	3	4	4	1	5	rs150496187	byFrequency	TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:219553529G>C	uc002viu.2	+	12	1756	c.1490G>C	c.(1489-1491)CGG>CCG	p.R497P	STK36_uc002viv.2_Missense_Mutation_p.R497P	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	497					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		TCCTTCTGCCGGGAGGCAGGG	0.587													41	31					0	0	0	0	C	219553529	C	C	219553529	3	2	82	1	0	0	0	0	1	0	0	0	15368	1116	39	3	1532	3	STK36	2	219553529	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	7009715	219553529	23645844	34	16304											
SH3BP4	23677	broad.mit.edu	37	chr2	235950335	235950336	+	Missense_Mutation	DNP	GG	TT	TT																															acttgcttggccaaagccctGgttggggccagacccaagcc																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr2:235950335_235950336GG>TT	uc002vvp.2	+	4	1315_1316	c.922_923GG>TT	c.(922-924)GGT>TTT	p.G308F	SH3BP4_uc010fym.2_Missense_Mutation_p.G308F|SH3BP4_uc002vvq.2_Missense_Mutation_p.G308F	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	308					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CCAAAGCCCTGGTTGGGGCCAG	0.594													19	47					0	0	0	0	TT	235950336	TT	TT	235950335	3	4	82	1	0	0	0	0	1	0	0	0	14311	1348	47	4	928	4	SH3BP4	2	235950335	Missense_Mutation	DNP	GG	TCGA-CN-6988-01A-11D-1912-08	16396806	235950335	7249038	35	16305											
LOC401052	401052	broad.mit.edu	37	chr3	10050254	10050254	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcccagagagcagggtcaGatagtggggggtgggttcag	9	6	19	7	0	2	2	2	0	0	2	2	3	2	2	1	5	2	2	1	5	1	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr3:10050254G>C	uc003bur.1	-	3	525	c.-89C>G	c.(-91--87)ATCTG>ATGTG		CIDEC_uc003bto.2_Intron	NM_001008737	NP_001008737	B3KMQ7	B3KMQ7_HUMAN	hypothetical protein LOC401052												0						AGCAGGGTCAGATAGtggggg	0.323													12	20					0	0	0	0	C	10050254	C	C	10050254	1	2	82	1	0	0	0	0	0	0	0	0	8926	957	33	2		2	LOC401052	3	10050254	Translation_Start_Site	SNP	G	TCGA-CN-6988-01A-11D-1912-08		10050254	187972176	36	16306											
SCN10A	6336	broad.mit.edu	37	chr3	38835351	38835351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caagtccagctggggccgagGcttctcttcttggtccttct	4	13	11	13	1	3	0	0	0	3	0	6	1	5	0	3	4	1	2	3	4	1	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr3:38835351G>A	uc003ciq.2	-	1	151	c.151C>T	c.(151-153)CCT>TCT	p.P51S		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	51					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGGGGCCGAGGCTTCTCTTCT	0.552													55	18					0	0	0	0	A	38835351	A	A	38835351	3	1	82	1	0	0	0	0	1	0	0	0	13977	1203	42	4	5827	4	SCN10A	3	38835351	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	28785097	38835351	159187079	37	16307											
ZNF502	91392	broad.mit.edu	37	chr3	44763729	44763729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgtgggaaagcctttgctCatagctcatctcttactgaa	11	13	8	9	0	3	1	2	1	1	0	4	2	3	2	1	1	4	2	1	1	5	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr3:44763729C>T	uc011baa.1	+	4	1675	c.1420C>T	c.(1420-1422)CAT>TAT	p.H474Y	ZNF502_uc003cns.2_Missense_Mutation_p.H474Y|ZNF502_uc011bab.1_Missense_Mutation_p.H474Y|ZNF502_uc003cnt.2_Missense_Mutation_p.H474Y	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	474	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		AGCCTTTGCTCATAGCTCATC	0.418													12	19					0	0	0	0	T	44763729	T	T	44763729	3	4	82	1	0	0	0	0	1	0	0	0	18017	826	29	2	1426	2	ZNF502	3	44763729	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	5928378	44763729	153258701	38	16308											
MYH15	22989	broad.mit.edu	37	chr3	108211382	108211382	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccagatagaatttgatagAatatgtggtagttcctctct	11	15	9	6	0	1	4	0	1	1	3	4	4	3	4	2	1	0	2	2	1	6	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr3:108211382A>T	uc003dxa.1	-	10	953	c.896T>A	c.(895-897)TTC>TAC	p.F299Y		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	299	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						AATTTGATAGAATATGTGGTA	0.373													7	20					0	0	0	0	T	108211382	T	T	108211382	3	4	82	1	0	0	0	0	1	0	0	0	10087	246	9	5	5076	5	MYH15	3	108211382	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	63447653	108211382	89811048	39	16309											
PLOD2	5352	broad.mit.edu	37	chr3	145790383	145790383	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agaccatttgccgtaatgttCcatttcttctaccaattcat	10	16	4	11	1	3	1	1	0	2	1	4	1	4	1	4	0	2	2	4	0	3	7			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr3:145790383C>T	uc003evs.1	-	16	2256	c.1750G>A	c.(1750-1752)GAA>AAA	p.E584K	PLOD2_uc003evq.1_Missense_Mutation_p.E265K|PLOD2_uc011bnm.1_Missense_Mutation_p.E550K|PLOD2_uc003evr.1_Missense_Mutation_p.E605K	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	584					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	CCGTAATGTTCCATTTCTTCT	0.368													14	53					0	0	0	0	T	145790383	T	T	145790383	3	4	82	1	0	0	0	0	1	0	0	0	12157	864	30	2	479	2	PLOD2	3	145790383	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	37579001	145790383	52232047	40	16310											
SI	6476	broad.mit.edu	37	chr3	164732915	164732915	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatcgatttagtacctttGcccaacaaatgtcattggtg	11	14	8	8	1	1	0	1	0	0	0	2	2	1	0	2	1	3	1	2	1	5	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr3:164732915G>A	uc003fei.2	-	33	4057	c.3995C>T	c.(3994-3996)GCA>GTA	p.A1332V		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1332	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAGTACCTTTGCCCAACAAAT	0.323										HNSCC(35;0.089)			12	31					0	0	0	0	A	164732915	A	A	164732915	3	1	82	1	0	0	0	0	1	0	0	0	14362	1319	46	4	1552	4	SI	3	164732915	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	18942532	164732915	33289515	41	16311											
TNIK	23043	broad.mit.edu	37	chr3	170784416	170784416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccacatccttagttatccGgccataggtgtttacataca	11	12	6	12	1	0	0	0	0	0	0	2	0	2	0	4	2	2	2	4	2	5	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr3:170784416G>A	uc003fhh.2	-	31	4153	c.3808C>T	c.(3808-3810)CGG>TGG	p.R1270W	TNIK_uc003fhi.2_Missense_Mutation_p.R1215W|TNIK_uc003fhj.2_Missense_Mutation_p.R1241W|TNIK_uc003fhk.2_Missense_Mutation_p.R1262W|TNIK_uc003fhl.2_Missense_Mutation_p.R1186W|TNIK_uc003fhm.2_Missense_Mutation_p.R1207W|TNIK_uc003fhn.2_Missense_Mutation_p.R1233W|TNIK_uc003fho.2_Missense_Mutation_p.R1178W|TNIK_uc003fhg.2_Missense_Mutation_p.R448W|TNIK_uc003fhp.2_Missense_Mutation_p.R202W	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1270	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TTAGTTATCCGGCCATAGGTG	0.458													11	99					0	0	0	0	A	170784416	A	A	170784416	3	1	82	1	0	0	0	0	1	0	0	0	16379	1115	39	1	286	1	TNIK	3	170784416	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	6051501	170784416	27238014	42	16312											
NLGN1	22871	broad.mit.edu	37	chr3	173322785	173322785	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccagaagtcatgcttcctGtgtggtttactaataacttg	9	15	9	8	0	1	1	1	0	0	1	2	1	2	1	2	1	4	2	2	1	4	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr3:173322785G>T	uc003fio.1	+	3	820	c.397G>T	c.(397-399)GTG>TTG	p.V133L	NLGN1_uc010hww.1_Missense_Mutation_p.V133L|NLGN1_uc003fip.1_Missense_Mutation_p.V133L	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	133	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CATGCTTCCTGTGTGGTTTAC	0.433													144	73					3.38734e-80	1.64898e-79	1	0	T	173322785	T	T	173322785	3	4	82	1	0	0	0	0	1	0	0	0	10515	1377	48	4	399	4	NLGN1	3	173322785	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	2538369	173322785	24699645	43	16313											
NAALADL2	254827	broad.mit.edu	37	chr3	174814816	174814816	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaccagcaacttcacccAaaggaaggttccagagactt	14	8	7	12	0	2	1	2	0	0	1	3	3	3	2	3	2	3	2	3	2	4	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr3:174814816A>G	uc003fit.2	+	2	367	c.280A>G	c.(280-282)AAA>GAA	p.K94E	NAALADL2_uc003fiu.1_Missense_Mutation_p.K87E	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	94	Cytoplasmic (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		AACTTCACCCAAAGGAAGGTT	0.433													11	70					0	0	0	0	G	174814816	G	G	174814816	3	3	82	1	0	0	0	0	1	0	0	0	10183	131	5	5	286	5	NAALADL2	3	174814816	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	1492031	174814816	23207614	44	16314											
ECE2	9718	broad.mit.edu	37	chr3	184002873	184002873	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcagcaggtgtcagagctCatcaaccgcacggaaccaag	12	6	11	12	2	3	1	3	0	0	1	3	2	3	2	2	2	5	4	2	2	3	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr3:184002873C>A	uc003fni.3	+	9	1520	c.1482C>A	c.(1480-1482)CTC>CTA	p.L494L	ECE2_uc011brh.1_Silent_p.L347L|ECE2_uc003fnl.3_Silent_p.L422L|ECE2_uc003fnm.3_Silent_p.L376L|ECE2_uc003fnk.3_Silent_p.L347L|ECE2_uc011bri.1_Silent_p.L409L|ECE2_uc010hxv.2_Silent_p.L138L	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	494	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGTCAGAGCTCATCAACCGCA	0.562											OREG0015945	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	125					1.9806e-07	7.84406e-07	1	0	A	184002873	A	A	184002873	2	1	82	1	0	0	0	0	0	0	0	1	4912	813	29	2		2	ECE2	3	184002873	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	9188057	184002873	14019557	45	16315											
CYTL1	54360	broad.mit.edu	37	chr4	5016894	5016894	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcccttagcgctgacgatctGgcaggaccgtagtcactggg	7	9	13	12	3	2	1	1	1	1	0	3	3	3	2	2	3	1	3	2	3	2	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr4:5016894G>A	uc003gig.2	-	4	420	c.395C>T	c.(394-396)CCA>CTA	p.P132L		NM_018659	NP_061129	Q9NRR1	CYTL1_HUMAN	cytokine-like 1 precursor	132					signal transduction	extracellular space|soluble fraction	receptor binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		CTGACGATCTGGCAGGACCGT	0.483													4	28					0	0	0	0	A	5016894	A	A	5016894	3	1	82	1	0	0	0	0	1	0	0	0	4225	1348	47	4	19	4	CYTL1	4	5016894	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08		5016894	186137382	46	16316											
LPHN3	23284	broad.mit.edu	37	chr4	62812754	62812754	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attctgttattgtcaattccCctgttattacggcagcaata	10	16	6	9	1	2	0	1	0	1	0	3	0	3	0	2	1	2	4	2	1	6	7			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr4:62812754C>G	uc010ihh.2	+	13	2511	c.2338C>G	c.(2338-2340)CCT>GCT	p.P780A	LPHN3_uc003hcq.3_Missense_Mutation_p.P780A|LPHN3_uc003hct.2_Missense_Mutation_p.P173A	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	767	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TGTCAATTCCCCTGTTATTAC	0.383													33	121					0	0	0	0	G	62812754	G	G	62812754	3	3	82	1	0	0	0	0	1	0	0	0	8967	623	22	4	2388	4	LPHN3	4	62812754	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	57795860	62812754	128341522	47	16317											
UGT2B28	54490	broad.mit.edu	37	chr4	70156309	70156309	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaattcatccaatcctaGgtcttccaaaaaccagagct	15	10	4	12	0	2	1	1	0	1	1	5	1	5	1	4	1	2	1	4	1	6	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr4:70156309G>A	uc003hej.2	+	5	1093	c.1091_splice	c.e5-1	p.G364_splice	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,						xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	TCCAATCCTAGGTCTTCCAAA	0.368													29	59					0	0	0	0	A	70156309	A	A	70156309	5	1	82	1	0	0	0	0	0	0	1	0	17028	1014	35	4	1108	4	UGT2B28	4	70156309	Splice_Site	SNP	G	TCGA-CN-6988-01A-11D-1912-08	7343555	70156309	120997967	48	16318											
CSN2	1447	broad.mit.edu	37	chr4	70823387	70823388	+	Missense_Mutation	DNP	GG	TT	TT																															ttccattatttcaggctgagGgacaggcagcaccacagcag																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr4:70823387_70823388GG>TT	uc003hes.3	-	5	292_293	c.279_280CC>AA	c.(277-282)GTCCCT>GTAACT	p.P94T	CSN2_uc003het.3_Missense_Mutation_p.P93T	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	94					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						TCAGGCTGAGGGACAGGCAGCA	0.47													13	63					0	0	0	0	TT	70823388	TT	TT	70823387	3	4	82	1	0	0	0	0	1	0	0	0	3965	1232	43	4	408	4	CSN2	4	70823387	Missense_Mutation	DNP	GG	TCGA-CN-6988-01A-11D-1912-08	667078	70823387	120330889	49	16319											
GRID2	2895	broad.mit.edu	37	chr4	94032099	94032099	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctacagccaaatccttcattActgaggtaagtgaaaattgt	14	12	7	8	0	1	2	1	2	0	0	2	2	2	2	2	1	3	1	2	1	6	5			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr4:94032099A>T	uc011cdt.1	+	4	988	c.730A>T	c.(730-732)ACT>TCT	p.T244S	GRID2_uc010ikx.2_Missense_Mutation_p.T244S|GRID2_uc011cdu.1_Missense_Mutation_p.T149S|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	244	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATCCTTCATTACTGAGGTAAG	0.408													27	34					0	0	0	0	T	94032099	T	T	94032099	3	4	82	1	0	0	0	0	1	0	0	0	6811	391	14	5	744	5	GRID2	4	94032099	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	23208712	94032099	97122177	50	16320											
UNC5C	8633	broad.mit.edu	37	chr4	96124103	96124103	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgaagttttcctccccgaCcaccaccacatcctggggga	8	8	10	15	1	0	1	0	1	0	0	3	3	3	2	7	3	0	1	7	3	1	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr4:96124103C>A	uc003htp.1	-	12	2069	c.1915G>T	c.(1915-1917)GTC>TTC	p.V639F	UNC5C_uc010ilc.1_Missense_Mutation_p.V658F	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	639	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TCCTCCCCGACCACCACCACA	0.602													20	16					0.000132079	0.000500472	1	0	A	96124103	A	A	96124103	3	1	82	1	0	0	0	0	1	0	0	0	17061	507	18	4	900	4	UNC5C	4	96124103	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	2092004	96124103	95030173	51	16321											
ANK2	287	broad.mit.edu	37	chr4	114277887	114277887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcatggactccaattccagtCcagaagaagtacaattccag	14	8	8	11	0	0	2	0	0	0	2	4	3	4	3	4	1	1	2	4	1	5	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr4:114277887C>T	uc003ibe.3	+	38	8213	c.8113C>T	c.(8113-8115)CCA>TCA	p.P2705S	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.P7S|ANK2_uc011cgb.1_Missense_Mutation_p.P2720S	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2672					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAATTCCAGTCCAGAAGAAGT	0.423													47	40					0	0	0	0	T	114277887	T	T	114277887	3	4	82	1	0	0	0	0	1	0	0	0	621	855	30	2	8328	2	ANK2	4	114277887	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	18153784	114277887	76876389	52	16322											
SYNPO2	171024	broad.mit.edu	37	chr4	119952081	119952081	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcactccttcaaaattcAgaaggcaaacggggcactgg	12	9	10	10	1	3	1	3	0	0	1	4	1	4	1	1	4	1	2	1	4	4	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr4:119952081A>T	uc003icm.3	+	4	2347	c.2151A>T	c.(2149-2151)TCA>TCT	p.S717S	SYNPO2_uc010ina.2_Silent_p.S717S|SYNPO2_uc010inb.2_Silent_p.S717S|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Silent_p.S645S	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	717						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						TTCAAAATTCAGAAGGCAAAC	0.493													14	34					0	0	0	0	T	119952081	T	T	119952081	2	4	82	1	0	0	0	0	0	0	0	1	15523	175	7	5		5	SYNPO2	4	119952081	Silent	SNP	A	TCGA-CN-6988-01A-11D-1912-08	5674194	119952081	71202195	53	16323											
PCDH10	57575	broad.mit.edu	37	chr4	134071332	134071332	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtttgccttgctctggatgGtggaaggagtcttttcccag	5	15	13	8	0	2	0	0	0	2	0	3	3	3	3	2	4	2	2	2	4	1	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr4:134071332G>C	uc003iha.2	+	1	863	c.37G>C	c.(37-39)GTG>CTG	p.V13L	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.V13L	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	13					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCTCTGGATGGTGGAAGGAGT	0.517													28	103					0	0	0	0	C	134071332	C	C	134071332	3	2	82	1	0	0	0	0	1	0	0	0	11561	1261	44	4	39	4	PCDH10	4	134071332	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	14119251	134071332	57082944	54	16324											
STOX2	56977	broad.mit.edu	37	chr4	184931953	184931953	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggagcctgtggggcacaaGgaggagtcaccaaaagggcc	12	3	17	9	0	1	0	1	0	0	0	1	3	1	3	3	6	1	1	3	6	3	0			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr4:184931953G>A	uc003ivz.1	+	3	3397	c.1962G>A	c.(1960-1962)AAG>AAA	p.K654K	STOX2_uc003iwa.1_Silent_p.K343K	NM_020225	NP_064610	Q9P2F5	STOX2_HUMAN	storkhead box 2	654					embryo development|maternal placenta development						0		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		TGGGGCACAAGGAGGAGTCAC	0.637													8	10					0	0	0	0	A	184931953	A	A	184931953	2	1	82	1	0	0	0	0	0	0	0	1	15386	991	35	4		4	STOX2	4	184931953	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	50860621	184931953	6222323	55	16325											
CDH10	1008	broad.mit.edu	37	chr5	24511543	24511543	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctacttcagcatttttccCagtgtcagcatcagttgctt	7	17	6	11	0	4	0	3	0	1	0	5	0	5	0	1	0	4	4	1	0	1	7			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:24511543C>A	uc003jgr.1	-	6	1227	c.895G>T	c.(895-897)GGG>TGG	p.G299W	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	299	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GCATTTTTCCCAGTGTCAGCA	0.423										HNSCC(23;0.051)			19	84					9.7654e-05	0.000372041	1	0	A	24511543	A	A	24511543	3	1	82	1	0	0	0	0	1	0	0	0	3111	594	21	4	1499	4	CDH10	5	24511543	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08		24511543	156403717	56	16326											
CDH9	1007	broad.mit.edu	37	chr5	26903856	26903856	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttctgcattttcccccaCgtcagggtcattggctttta	6	16	7	12	1	3	0	2	0	1	0	4	0	4	0	2	2	1	2	2	2	1	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:26903856C>T	uc003jgs.1	-	6	1058	c.889G>A	c.(889-891)GTG>ATG	p.V297M	CDH9_uc010iug.2_Missense_Mutation_p.V297M	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	297	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTTTCCCCCACGTCAGGGTCA	0.413													35	126					0	0	0	0	T	26903856	T	T	26903856	3	4	82	1	0	0	0	0	1	0	0	0	3132	536	19	1	1508	1	CDH9	5	26903856	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	2392313	26903856	154011404	57	16327											
CDH6	1004	broad.mit.edu	37	chr5	31323131	31323131	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggacattgtgcccgaagccCttttcctaccccgacggact	7	9	10	15	3	0	0	0	0	0	0	1	4	1	2	5	2	3	0	5	2	2	4	rs149310360		TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:31323131C>A	uc003jhe.1	+	12	2415	c.2089C>A	c.(2089-2091)CTT>ATT	p.L697I		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	697	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding	p.L697F(1)		ovary(4)|skin(2)|large_intestine(1)	7						GCCCGAAGCCCTTTTCCTACC	0.522													26	41					1.2476e-16	5.43209e-16	1	0	A	31323131	A	A	31323131	3	1	82	1	0	0	0	0	1	0	0	0	3129	681	24	4	2131	4	CDH6	5	31323131	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	4419275	31323131	149592129	58	16328											
NIPBL	25836	broad.mit.edu	37	chr5	37052609	37052609	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttactccatgatccgtggaAaccgccaacacagacgagcc	12	7	8	14	3	0	2	0	1	0	1	2	4	2	3	5	1	4	0	5	1	3	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:37052609A>G	uc003jkl.3	+	42	7703	c.7204A>G	c.(7204-7206)AAC>GAC	p.N2402D	NIPBL_uc003jkk.3_Missense_Mutation_p.N2402D|NIPBL_uc003jkn.2_Missense_Mutation_p.N95D	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2402					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GATCCGTGGAAACCGCCAACA	0.413													19	47					0	0	0	0	G	37052609	G	G	37052609	3	3	82	1	0	0	0	0	1	0	0	0	10482	14	1	5	7366	5	NIPBL	5	37052609	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	5729478	37052609	143862651	59	16329											
ITGA1	3672	broad.mit.edu	37	chr5	52211340	52211340	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacactgaaattttttggccAgtctatccacggagaaatgg	12	11	10	8	1	1	2	0	1	1	1	2	4	2	2	2	3	0	0	2	3	3	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:52211340A>T	uc003jou.2	+	15	1956	c.1904A>T	c.(1903-1905)CAG>CTG	p.Q635L	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Missense_Mutation_p.Q166L	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	635	Extracellular (Potential).|FG-GAP 7.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				TTTTTTGGCCAGTCTATCCAC	0.418													66	19					0	0	0	0	T	52211340	T	T	52211340	3	4	82	1	0	0	0	0	1	0	0	0	7911	188	7	5	1962	5	ITGA1	5	52211340	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	15158731	52211340	128703920	60	16330											
RASGRF2	5924	broad.mit.edu	37	chr5	80366391	80366391	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagatccagacatcaagaaGattaaaaaggtagggcctgg	17	6	12	6	0	1	4	1	0	0	4	2	5	2	4	2	3	0	1	2	3	7	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:80366391G>T	uc003kha.1	+	4	624	c.624G>T	c.(622-624)AAG>AAT	p.K208N	RASGRF2_uc011ctn.1_RNA|RASGRF2_uc003khb.1_Missense_Mutation_p.K36N	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	208	IQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		ACATCAAGAAGATTAAAAAGG	0.473													14	19					1.5842e-08	6.45654e-08	1	0	T	80366391	T	T	80366391	3	4	82	1	0	0	0	0	1	0	0	0	13138	933	33	2	638	2	RASGRF2	5	80366391	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	28155051	80366391	100548869	61	16331											
MEF2C	4208	broad.mit.edu	37	chr5	88018719	88018719	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagagatttgaactctgaGataaatgagtgctagtgcaa	14	10	13	4	0	1	4	0	3	1	2	1	7	1	5	0	1	3	2	0	1	5	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:88018719G>C	uc003kjj.2	-	11	1797	c.1124C>G	c.(1123-1125)TCT>TGT	p.S375C	MEF2C_uc003kji.2_Missense_Mutation_p.S367C|MEF2C_uc003kjk.2_Missense_Mutation_p.S375C|MEF2C_uc003kjm.2_Missense_Mutation_p.S365C|MEF2C_uc003kjl.2_Missense_Mutation_p.S385C	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	375	Transcription repressor.				apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		TGAACTCTGAGATAAATGAGT	0.478										HNSCC(66;0.2)			5	8					0	0	0	0	C	88018719	C	C	88018719	3	2	82	1	0	0	0	0	1	0	0	0	9510	942	33	2	301	2	MEF2C	5	88018719	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	7652328	88018719	92896541	62	16332											
FER	2241	broad.mit.edu	37	chr5	108523253	108523253	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacttcagaaagagctcactAtcatcaagagaaaactcaca	19	7	5	10	0	5	3	5	0	0	3	5	4	5	3	0	0	3	1	0	0	6	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:108523253A>G	uc003kop.1	+	20	2830	c.2446A>G	c.(2446-2448)ATC>GTC	p.I816V	FER_uc011cvg.1_Missense_Mutation_p.I641V	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	816	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		AGAGCTCACTATCATCAAGAG	0.418													17	6					0	0	0	0	G	108523253	G	G	108523253	3	3	82	1	0	0	0	0	1	0	0	0	5845	449	16	5	2516	5	FER	5	108523253	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	20504534	108523253	72392007	63	16333											
ZNF608	57507	broad.mit.edu	37	chr5	124080436	124080436	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacagaagcaaattttaGgccatcagctaaggctgcgg	13	8	11	9	1	1	2	1	1	0	1	1	2	1	2	1	3	4	3	1	3	5	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:124080436G>C	uc003ktq.1	-	1	370	c.247C>G	c.(247-249)CTA>GTA	p.L83V	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Missense_Mutation_p.L83V|ZNF608_uc003ktt.1_Missense_Mutation_p.L83V	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	83						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCAAATTTTAGGCCATCAGCT	0.493													18	18					0	0	0	0	C	124080436	C	C	124080436	3	2	82	1	0	0	0	0	1	0	0	0	18101	991	35	4	4327	4	ZNF608	5	124080436	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	15557183	124080436	56834824	64	16334											
PCDHB16	57717	broad.mit.edu	37	chr5	140563721	140563721	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccctgcgggagttcgagttCcgcgtgagcgccacagaccg	6	6	15	14	6	0	2	0	1	0	1	2	4	1	3	4	1	2	2	4	1	0	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:140563721C>T	uc003liv.2	+	1	2742	c.1587C>T	c.(1585-1587)TTC>TTT	p.F529F		NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	529	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTTCGAGTTCCGCGTGAGCG	0.682													62	13					0	0	0	0	T	140563721	T	T	140563721	2	4	82	1	0	0	0	0	0	0	0	1	11595	854	30	2		2	PCDHB16	5	140563721	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	16483285	140563721	40351539	65	16335											
DOCK2	1794	broad.mit.edu	37	chr5	169446055	169446055	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagctccggaaagccaccatAccaatcttcttcgacatgat	12	9	7	13	2	2	1	0	1	2	0	4	4	3	2	4	1	3	1	4	1	3	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr5:169446055A>G	uc003maf.2	+	33	3404	c.3324A>G	c.(3322-3324)ATA>ATG	p.I1108M	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.I600M	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1108	Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAGCCACCATACCAATCTTCT	0.453													115	42					0	0	0	0	G	169446055	G	G	169446055	3	3	82	1	0	0	0	0	1	0	0	0	4709	381	14	5	3454	5	DOCK2	5	169446055	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	28882334	169446055	11469205	66	16336											
F13A1	2162	broad.mit.edu	37	chr6	6266819	6266819	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaggattgaagagaatgtaCgtgtctgtttctgggtttcg	9	14	13	5	2	2	2	0	1	2	1	3	4	2	3	0	2	1	3	0	2	4	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:6266819C>T	uc003mwv.2	-	4	666	c.543G>A	c.(541-543)ACG>ACA	p.T181T	F13A1_uc011dib.1_Silent_p.T118T	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	181					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	AGAGAATGTACGTGTCTGTTT	0.368													23	70					0	0	0	0	T	6266819	T	T	6266819	2	4	82	1	0	0	0	0	0	0	0	1	5365	523	19	1		1	F13A1	6	6266819	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08		6266819	164848248	67	16337											
CPNE5	57699	broad.mit.edu	37	chr6	36767826	36767826	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcaggattgagcgtgttgtCgatgacttcggtgcgcccaa	7	11	14	9	4	1	2	1	2	0	0	3	4	1	3	1	2	2	1	1	2	1	3	rs148202375		TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:36767826C>T	uc003omr.1	-	4	272	c.205G>A	c.(205-207)GAC>AAC	p.D69N	CPNE5_uc003oms.1_Missense_Mutation_p.D31N	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V	69	C2 1.									skin(1)	1						AGCGTGTTGTCGATGACTTCG	0.562													8	27					0	0	0	0	T	36767826	T	T	36767826	3	4	82	1	0	0	0	0	1	0	0	0	3830	884	31	1	1648	1	CPNE5	6	36767826	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	30501007	36767826	134347241	68	16338											
KCNK16	83795	broad.mit.edu	37	chr6	39285582	39285582	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgggagcgcctgggacggtCctcccatctttcaatggcgg	5	9	14	13	3	2	0	1	0	1	0	4	2	4	2	3	5	1	0	3	5	1	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:39285582C>A	uc003ooq.2	-	3	489	c.475G>T	c.(475-477)GAC>TAC	p.D159Y	KCNK16_uc003oor.3_Missense_Mutation_p.D159Y|KCNK16_uc010jwy.2_Missense_Mutation_p.D159Y|KCNK16_uc011dtz.1_Missense_Mutation_p.D159Y	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	159	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						CTGGGACGGTCCTCCCATCTT	0.498													11	8					1.58986e-06	6.19164e-06	1	0	A	39285582	A	A	39285582	3	1	82	1	0	0	0	0	1	0	0	0	8102	855	30	2	855	2	KCNK16	6	39285582	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	2517756	39285582	131829485	69	16339											
GPR116	221395	broad.mit.edu	37	chr6	46849211	46849211	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgatagtaactgcttgaaaGgagttgtagtccattttgta	11	15	10	5	0	0	2	0	2	0	0	1	3	1	3	1	1	2	5	1	1	5	8			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:46849211G>T	uc003oyo.3	-	8	1084	c.795C>A	c.(793-795)TCC>TCA	p.S265S	GPR116_uc003oyp.3_Silent_p.S265S|GPR116_uc003oyq.3_Silent_p.S265S|GPR116_uc010jzi.1_5'Flank|GPR116_uc003oyr.2_Silent_p.S265S	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	265	SEA.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CTGCTTGAAAGGAGTTGTAGT	0.353													18	43					5.35267e-07	2.10799e-06	1	0	T	46849211	T	T	46849211	2	4	82	1	0	0	0	0	0	0	0	1	6671	987	35	4		4	GPR116	6	46849211	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	7563629	46849211	124265856	70	16340											
REV3L	5980	broad.mit.edu	37	chr6	111689002	111689002	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgacttggggcacatttgcAaggcataatcacaatttttt	11	14	8	8	1	1	0	1	0	0	0	2	1	1	0	0	3	1	3	0	3	3	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:111689002A>T	uc003puy.3	-	14	6312	c.5989T>A	c.(5989-5991)TGC>AGC	p.C1997S	REV3L_uc003pux.3_Missense_Mutation_p.C1919S|REV3L_uc003puz.3_Missense_Mutation_p.C1919S|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1997					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GCACATTTGCAAGGCATAATC	0.453								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					27	63					0	0	0	0	T	111689002	T	T	111689002	3	4	82	1	0	0	0	0	1	0	0	0	13305	130	5	5	3479	5	REV3L	6	111689002	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	64839791	111689002	59426065	71	16341											
LAMA2	3908	broad.mit.edu	37	chr6	129670496	129670496	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgactaccgctgcacggcttGtccacggggatatgaaggcc	8	7	13	13	4	0	1	0	1	0	0	1	3	1	2	3	4	2	3	3	4	3	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:129670496G>A	uc003qbn.2	+	31	4595	c.4490G>A	c.(4489-4491)TGT>TAT	p.C1497Y	LAMA2_uc003qbo.2_Missense_Mutation_p.C1497Y	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1497	Laminin EGF-like 16.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGCACGGCTTGTCCACGGGGA	0.433													20	35					0	0	0	0	A	129670496	A	A	129670496	3	1	82	1	0	0	0	0	1	0	0	0	8646	1377	48	4	4612	4	LAMA2	6	129670496	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	17981494	129670496	41444571	72	16342											
TMEM200A	114801	broad.mit.edu	37	chr6	130762658	130762658	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtacaagtcatctatggCtctcggacctggggctggac	8	10	12	11	1	4	0	2	0	2	0	5	2	4	2	1	5	1	3	1	5	3	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:130762658C>G	uc003qca.2	+	3	1962	c.1091C>G	c.(1090-1092)GCT>GGT	p.A364G	TMEM200A_uc010kfh.2_Missense_Mutation_p.A364G|TMEM200A_uc010kfi.2_Missense_Mutation_p.A364G|TMEM200A_uc003qcb.2_Missense_Mutation_p.A364G	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	364	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TCATCTATGGCTCTCGGACCT	0.527													17	30					0	0	0	0	G	130762658	G	G	130762658	3	3	82	1	0	0	0	0	1	0	0	0	16189	797	28	4	1093	4	TMEM200A	6	130762658	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	1092162	130762658	40352409	73	16343											
EPB41L2	2037	broad.mit.edu	37	chr6	131277410	131277410	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtatgaaccgagaaataccCctgctctccgatgtttcctt	9	12	8	12	2	1	2	0	1	1	1	3	4	2	2	5	1	3	3	5	1	4	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:131277410C>A	uc003qch.2	-	2	398	c.216G>T	c.(214-216)AGG>AGT	p.R72S	EPB41L2_uc003qcg.1_Missense_Mutation_p.R72S|EPB41L2_uc011eby.1_Missense_Mutation_p.R72S|EPB41L2_uc003qci.2_Missense_Mutation_p.R72S|EPB41L2_uc010kfk.2_Missense_Mutation_p.R72S|EPB41L2_uc010kfl.1_Missense_Mutation_p.R72S	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	72					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		GAGAAATACCCCTGCTCTCCG	0.363													35	70					3.76114e-14	1.61752e-13	1	0	A	131277410	A	A	131277410	3	1	82	1	0	0	0	0	1	0	0	0	5177	622	22	4	2873	4	EPB41L2	6	131277410	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	514752	131277410	39837657	74	16344											
MOXD1	26002	broad.mit.edu	37	chr6	132619016	132619016	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagagaccttcctttttagtCcatttaaacttattcatagc	11	16	5	9	0	1	1	1	0	0	1	3	3	3	1	3	0	2	0	3	0	5	9	rs140134245	by1000genomes	TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:132619016C>G	uc003qdf.2	-	11	1686	c.1587G>C	c.(1585-1587)TGG>TGC	p.W529C	MOXD1_uc003qde.2_Missense_Mutation_p.W461C	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	529	Lumenal (Potential).				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		CCTTTTTAGTCCATTTAAACT	0.403													14	28					0	0	0	0	G	132619016	G	G	132619016	3	3	82	1	0	0	0	0	1	0	0	0	9773	856	30	2	262	2	MOXD1	6	132619016	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	1341606	132619016	38496051	75	16345											
HEBP2	23593	broad.mit.edu	37	chr6	138734184	138734184	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatgaagtgtggttgattcAaaaaaatgaacccaccaaag	18	9	8	6	0	1	3	1	3	0	0	1	3	1	3	2	1	1	1	2	1	7	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:138734184A>C	uc003qhw.1	+	4	884	c.587A>C	c.(586-588)CAA>CCA	p.Q196P		NM_014320	NP_055135	Q9Y5Z4	HEBP2_HUMAN	heme binding protein 2	196						mitochondrion					0	Breast(32;0.0933)			GBM - Glioblastoma multiforme(68;0.000732)|OV - Ovarian serous cystadenocarcinoma(155;0.00171)		TGGTTGATTCAAAAAAATGAA	0.363													43	48					0	0	0	0	C	138734184	C	C	138734184	3	2	82	1	0	0	0	0	1	0	0	0	7076	130	5	5	601	5	HEBP2	6	138734184	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	6115168	138734184	32380883	76	16346											
HIVEP2	3097	broad.mit.edu	37	chr6	143095631	143095631	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacgatgcggtggatattgcTtctctgcgacttgctgcacc	6	12	12	11	3	1	0	0	0	1	0	2	4	1	1	1	2	5	3	1	2	1	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr6:143095631T>G	uc003qjd.2	-	5	988	c.245A>C	c.(244-246)AAG>ACG	p.K82T		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	82					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TGGATATTGCTTCTCTGCGAC	0.527													36	66					0	0	0	0	G	143095631	G	G	143095631	3	3	82	1	0	0	0	0	1	0	0	0	7226	1609	56	5	7119	5	HIVEP2	6	143095631	Missense_Mutation	SNP	T	TCGA-CN-6988-01A-11D-1912-08	4361447	143095631	28019436	77	16347											
COL28A1	340267	broad.mit.edu	37	chr7	7412808	7412808	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcagtttctctttatcaCgagaatctgtctgtccatca	8	16	6	11	1	6	1	3	0	3	1	8	2	7	1	1	0	0	1	1	0	2	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr7:7412808C>T	uc003src.1	-	32	2846	c.2729G>A	c.(2728-2730)CGT>CAT	p.R910H	COL28A1_uc011jxe.1_Missense_Mutation_p.R593H	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	910	VWFA 2.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CTCTTTATCACGAGAATCTGT	0.453													17	37					0	0	0	0	T	7412808	T	T	7412808	3	4	82	1	0	0	0	0	1	0	0	0	3701	536	19	1	664	1	COL28A1	7	7412808	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08		7412808	151725855	78	16348											
PTPN12	5782	broad.mit.edu	37	chr7	77212881	77212881	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accatttttagggcgtctatGggccaaaagcatatgtagca	12	11	10	8	1	1	0	0	0	1	0	1	0	1	0	2	2	2	3	2	2	6	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr7:77212881G>A	uc003ugh.2	+	4	386	c.295G>A	c.(295-297)GGG>AGG	p.G99R	PTPN12_uc011kgp.1_5'UTR|PTPN12_uc011kgq.1_Intron|PTPN12_uc010ldq.1_RNA|PTPN12_uc010ldr.1_Intron	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	99	Tyrosine-protein phosphatase.					soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						GGGCGTCTATGGGCCAAAAGC	0.299													18	27					0	0	0	0	A	77212881	A	A	77212881	3	1	82	1	0	0	0	0	1	0	0	0	12844	1348	47	4	309	4	PTPN12	7	77212881	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	69800073	77212881	81925782	79	16349											
ABCB1	5243	broad.mit.edu	37	chr7	87179361	87179361	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcctaatatcctgtccatCaacactgacctggaataaaa	14	10	6	11	0	1	1	1	1	0	0	4	2	4	2	4	2	1	0	4	2	6	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr7:87179361C>T	uc003uiz.1	-	14	1778	c.1360G>A	c.(1360-1362)GAT>AAT	p.D454N	ABCB1_uc011khc.1_Missense_Mutation_p.D390N	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	454	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCCTGTCCATCAACACTGACC	0.413													44	54					0	0	0	0	T	87179361	T	T	87179361	3	4	82	1	0	0	0	0	1	0	0	0	40	826	29	2	2546	2	ABCB1	7	87179361	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	9966480	87179361	71959302	80	16350											
TRRAP	8295	broad.mit.edu	37	chr7	98501107	98501107	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaggagcttctgattgctGccaaacacatcctcaccaca	13	8	7	13	0	2	1	1	1	1	0	3	3	3	2	3	1	4	2	3	1	2	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr7:98501107G>T	uc003upp.2	+	12	1212	c.1003G>T	c.(1003-1005)GCC>TCC	p.A335S	TRRAP_uc011kis.1_Missense_Mutation_p.A335S|TRRAP_uc003upr.2_Missense_Mutation_p.A27S	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	335					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCTGATTGCTGCCAAACACAT	0.498													34	70					1.47244e-24	6.88122e-24	1	0	T	98501107	T	T	98501107	3	4	82	1	0	0	0	0	1	0	0	0	16668	1319	46	4	1045	4	TRRAP	7	98501107	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	11321746	98501107	60637556	81	16351											
RELN	5649	broad.mit.edu	37	chr7	103214584	103214584	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgtccgggcttcccttttcCcagggccattgaagtagaga	7	10	11	13	2	0	2	0	1	0	1	3	3	3	2	5	2	0	2	5	2	2	5			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr7:103214584C>A	uc003vca.2	-	30	4626	c.4466G>T	c.(4465-4467)GGG>GTG	p.G1489V	RELN_uc010liz.2_Missense_Mutation_p.G1489V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1489					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCCCTTTTCCCAGGGCCATT	0.473													621	142					8.2041e-283	4.02173e-282	1	0	A	103214584	A	A	103214584	3	1	82	1	0	0	0	0	1	0	0	0	13285	623	22	4	6060	4	RELN	7	103214584	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	4713477	103214584	55924079	82	16352											
DPP6	1804	broad.mit.edu	37	chr7	154664386	154664386	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttcaccgacaccacccactaCcctctgctcctggtggtgta	7	10	7	17	1	2	0	1	0	1	0	3	1	3	0	5	2	2	2	5	2	2	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr7:154664386C>A	uc003wlk.2	+	19	1995	c.1866C>A	c.(1864-1866)TAC>TAA	p.Y622*	DPP6_uc003wli.2_Nonsense_Mutation_p.Y558*|DPP6_uc003wlm.2_Nonsense_Mutation_p.Y560*|DPP6_uc011kvq.1_Nonsense_Mutation_p.Y515*	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	622	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CCACCCACTACCCTCTGCTCC	0.547													6	4					0.00198382	0.007243	1	0	A	154664386	A	A	154664386	4	1	82	1	0	0	0	0	0	1	0	0	4752	518	18	4	2056	4	DPP6	7	154664386	Nonsense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	51449802	154664386	4474277	83	16353											
MTUS1	57509	broad.mit.edu	37	chr8	17611420	17611431	+	In_Frame_Del	DEL	ACGCAGAAACGG	-	-																															gcctttgatcttctgaaacaAcgcagaaacggacccggtct																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr8:17611420_17611431delACGCAGAAACGG	uc003wxv.2	-	2	2360_2371	c.1886_1897delCCGTTTCTGCGT	c.(1885-1899)TCCGTTTCTGCGTTG>TTG	p.SVSA629del	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_In_Frame_Del_p.SVSA629del|MTUS1_uc010lsz.2_In_Frame_Del_p.SVSA629del	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	629_632						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		TTCTGAAACAACGCAGAAACGGACCCGGTCTC	0.434													---	---	---								-	17611431	-	-	17611420	7	5	82	1	0	1	0	1	0	0	0	0	10018	40	2	0	2290	0	MTUS1	8	17611420	In_Frame_Del	DEL	ACGCAGAAACGG	TCGA-CN-6988-01A-11D-1912-08		17611420	128752602	84	16354											
ADAM28	10863	broad.mit.edu	37	chr8	24167753	24167753	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccacaagcccacaaattaTggtataacggagtctcttca	14	9	6	12	1	2	0	1	0	1	0	3	1	2	1	2	2	2	1	2	2	5	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr8:24167753T>A	uc003xdy.2	+	4	388	c.305T>A	c.(304-306)ATG>AAG	p.M102K	ADAM28_uc003xdx.2_Missense_Mutation_p.M102K|ADAM28_uc011kzz.1_5'UTR|ADAM28_uc011laa.1_RNA	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	102					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CCACAAATTATGGTATAACGG	0.403													6	26					0	0	0	0	A	24167753	A	A	24167753	3	1	82	1	0	0	0	0	1	0	0	0	246	1478	51	5	319	5	ADAM28	8	24167753	Missense_Mutation	SNP	T	TCGA-CN-6988-01A-11D-1912-08	6556333	24167753	122196269	85	16355											
EBF2	64641	broad.mit.edu	37	chr8	25720221	25720231	+	Splice_Site	DEL	TTACCTTAGCT	-	-																															atgtcaatttccaaagcacaTtaccttagctaatctctcag																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr8:25720221_25720231delTTACCTTAGCT	uc003xes.1	-	11	1115	c.1098_splice	c.e11+1	p.K366_splice	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_Splice_Site	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		CCAAAGCACATTACCTTAGCTAATCTCTCAG	0.403													---	---	---								-	25720231	-	-	25720221	8	5	82	1	0	1	0	1	0	0	1	0	4903	1508	52	0		0	EBF2	8	25720221	Splice_Site	DEL	TTACCTTAGCT	TCGA-CN-6988-01A-11D-1912-08	1552468	25720221	120643801	86	16356											
TRIM35	23087	broad.mit.edu	37	chr8	27145584	27145584	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agccatggttggtgacgctgGtgaggtcgtcagacacggag	8	8	17	8	3	1	3	1	2	0	1	2	4	1	4	1	5	1	2	1	5	0	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr8:27145584G>C	uc003xfl.1	-	6	1047	c.965C>G	c.(964-966)ACC>AGC	p.T322S	TRIM35_uc010lup.1_3'UTR	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	322	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		GGTGACGCTGGTGAGGTCGTC	0.627													15	48					0	0	0	0	C	27145584	C	C	27145584	3	2	82	1	0	0	0	0	1	0	0	0	16576	1261	44	4	520	4	TRIM35	8	27145584	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	1425363	27145584	119218438	87	16357											
DDHD2	23259	broad.mit.edu	37	chr8	38092023	38092023	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaactggcatcggaagtgaGacgatgtacgtggttttaca	11	11	13	6	3	0	2	0	2	0	1	1	5	0	3	0	3	3	3	0	3	4	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr8:38092023G>A	uc003xlb.2	+	3	709	c.332G>A	c.(331-333)AGA>AAA	p.R111K	DDHD2_uc003xla.2_Missense_Mutation_p.R111K|DDHD2_uc003xlc.2_Missense_Mutation_p.R111K|DDHD2_uc011lbl.1_5'UTR	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	111	WWE.				lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			TCGGAAGTGAGACGATGTACG	0.448													41	90					0	0	0	0	A	38092023	A	A	38092023	3	1	82	1	0	0	0	0	1	0	0	0	4344	942	33	2	338	2	DDHD2	8	38092023	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	10946439	38092023	108271999	88	16358											
UBXN2B	137886	broad.mit.edu	37	chr8	59358527	59358527	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggaggataaatcaatacttAatgcagttgttcttattgat	14	15	8	4	0	2	1	1	1	1	0	2	3	2	3	0	2	2	3	0	2	6	7			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr8:59358527A>C	uc003xtl.2	+	7	855	c.733A>C	c.(733-735)AAT>CAT	p.N245H		NM_001077619	NP_001071087	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	245						cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				ovary(2)	2						ATCAATACTTAATGCAGTTGT	0.353													17	47					0	0	0	0	C	59358527	C	C	59358527	3	2	82	1	0	0	0	0	1	0	0	0	16983	362	13	5	759	5	UBXN2B	8	59358527	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	21266504	59358527	87005495	89	16359											
CHD7	55636	broad.mit.edu	37	chr8	61764637	61764637	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actggcctaacacttcaaccCtgactacacgtctgcgccgg	9	8	8	16	3	2	1	1	1	1	0	2	1	2	1	3	2	4	0	3	2	3	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr8:61764637C>A	uc003xue.2	+	29	6202	c.5725C>A	c.(5725-5727)CTG>ATG	p.L1909M		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1909					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CACTTCAACCCTGACTACACG	0.498													13	21					1.05317e-09	4.34278e-09	1	0	A	61764637	A	A	61764637	3	1	82	1	0	0	0	0	1	0	0	0	3345	680	24	4	5835	4	CHD7	8	61764637	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	2406110	61764637	84599385	90	16360											
TCEB1	6921	broad.mit.edu	37	chr8	74858964	74858964	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgttagtgtagcgaacCttgtacgtaaaatacatgca	13	11	10	7	2	0	0	0	0	0	0	0	2	0	0	1	0	6	6	1	0	7	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr8:74858964C>T	uc003xzx.1	-	4	325	c.240G>A	c.(238-240)AAG>AAA	p.K80K	TCEB1_uc003xzy.1_Silent_p.K80K|TCEB1_uc003xzz.1_Silent_p.K64K|TCEB1_uc003yaa.1_Silent_p.K80K	NM_005648	NP_005639	Q15369	ELOC_HUMAN	elongin C	80					interspecies interaction between organisms|positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm	protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0136)|all cancers(69;0.0431)|BRCA - Breast invasive adenocarcinoma(89;0.0499)			TGTAGCGAACCTTGTACGTAA	0.413													18	20					0	0	0	0	T	74858964	T	T	74858964	2	4	82	1	0	0	0	0	0	0	0	1	15745	680	24	4		4	TCEB1	8	74858964	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	13094327	74858964	71505058	91	16361											
UBR5	51366	broad.mit.edu	37	chr8	103358499	103358499	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attcgctggctgtatcatccCcatcatctccatcttcatca	8	14	4	15	1	6	0	4	0	2	0	9	0	7	0	3	1	0	3	3	1	1	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr8:103358499C>A	uc003ykr.1	-	7	734	c.701G>T	c.(700-702)GGG>GTG	p.G234V	UBR5_uc003yks.1_Missense_Mutation_p.G234V	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	234					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGTATCATCCCCATCATCTCC	0.428													48	67					3.76525e-18	1.67053e-17	1	0	A	103358499	A	A	103358499	3	1	82	1	0	0	0	0	1	0	0	0	16973	623	22	4	7910	4	UBR5	8	103358499	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	28499535	103358499	43005523	92	16362											
FANCG	2189	broad.mit.edu	37	chr9	35079225	35079225	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtcgcctcagagtcagaccgGagttctgagccacctgccac	8	7	11	15	2	3	3	2	1	1	2	4	4	3	4	5	1	2	1	5	1	0	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr9:35079225G>C	uc003zwb.1	-	2	590	c.98C>G	c.(97-99)TCC>TGC	p.S33C	FANCG_uc003zwa.1_5'Flank|FANCG_uc010mkj.1_5'UTR|FANCG_uc011lot.1_Missense_Mutation_p.S33C	NM_004629	NP_004620	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	33					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|large_intestine(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGTCAGACCGGAGTTCTGAGC	0.572			Mis|N|F|S			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				4	5					0	0	0	0	C	35079225	C	C	35079225	3	2	82	1	0	0	0	0	1	0	0	0	5700	1174	41	2	1822	2	FANCG	9	35079225	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08		35079225	106134206	93	16363											
TDRD7	23424	broad.mit.edu	37	chr9	100222478	100222479	+	Missense_Mutation	DNP	GG	TT	TT																															aggtggagaaaccttgcagtGgtggccaagatttacttctt																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr9:100222478_100222479GG>TT	uc004axj.2	+	7	1099_1100	c.874_875GG>TT	c.(874-876)GGT>TTT	p.G292F	TDRD7_uc011lux.1_Missense_Mutation_p.G218F	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	292	Lotus/OST-HTH 2.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				ACCTTGCAGTGGTGGCCAAGAT	0.376													10	38					0	0	0	0	TT	100222479	TT	TT	100222478	3	4	82	1	0	0	0	0	1	0	0	0	15801	1348	47	4	896	4	TDRD7	9	100222478	Missense_Mutation	DNP	GG	TCGA-CN-6988-01A-11D-1912-08	65143253	100222478	40990953	94	16364											
TUBB2C	10383	broad.mit.edu	37	chr9	140137531	140137531	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taccgggcgctgaccgtgccCgagctcacccagcagatgtt	7	7	12	15	4	1	2	1	1	0	1	1	3	1	2	4	1	4	4	4	1	1	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr9:140137531C>T	uc004cmh.1	+	4	963	c.861C>T	c.(859-861)CCC>CCT	p.P287P	TUBB2C_uc004cmg.1_Silent_p.P141P	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	287					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TGACCGTGCCCGAGCTCACCC	0.657													41	36					0	0	0	0	T	140137531	T	T	140137531	2	4	82	1	0	0	0	0	0	0	0	1	16824	639	23	1		1	TUBB2C	9	140137531	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	39915053	140137531	1075900	95	16365											
GATA3	2625	broad.mit.edu	37	chr10	8100734	8100734	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctccggactcttccccccCagcagcctgctgggcggctc	4	7	11	19	2	1	0	0	0	1	0	4	1	3	1	5	3	4	4	5	3	0	1	rs143582578		TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr10:8100734C>A	uc001ika.2	+	3	1265	c.708C>A	c.(706-708)CCC>CCA	p.P236P	GATA3_uc001ijz.2_Silent_p.P236P	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	236					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						TCTTCCCCCCCAGCAGCCTGC	0.682			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						18	25					1.01871e-10	4.30191e-10	1	0	A	8100734	A	A	8100734	2	1	82	1	0	0	0	0	0	0	0	1	6290	581	21	4		4	GATA3	10	8100734	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08		8100734	127434013	96	16366											
CUBN	8029	broad.mit.edu	37	chr10	17142173	17142173	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatctccatcataaacctgAagaaactcgtgtggacagtt	14	10	8	9	1	2	2	1	1	1	1	4	4	2	3	2	1	2	1	2	1	5	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr10:17142173A>C	uc001ioo.2	-	14	1648	c.1596T>G	c.(1594-1596)CTT>CTG	p.L532L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	532	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CATAAACCTGAAGAAACTCGT	0.413													16	34					0	0	0	0	C	17142173	C	C	17142173	2	2	82	1	0	0	0	0	0	0	0	1	4068	233	9	5		5	CUBN	10	17142173	Silent	SNP	A	TCGA-CN-6988-01A-11D-1912-08	9041439	17142173	118392574	97	16367											
A1CF	29974	broad.mit.edu	37	chr10	52575977	52575977	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgtgcctcgggtatacctAacataactgtccttgtccac	8	12	7	14	1	0	0	0	0	0	0	3	0	2	0	5	1	4	1	5	1	4	5			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr10:52575977A>T	uc001jjj.2	-	9	1118	c.930T>A	c.(928-930)GTT>GTA	p.V310V	A1CF_uc010qhn.1_Silent_p.V318V|A1CF_uc001jji.2_Silent_p.V310V|A1CF_uc001jjh.2_Silent_p.V318V|A1CF_uc010qho.1_Silent_p.V318V|A1CF_uc009xov.2_Silent_p.V310V	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	310					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						GGGTATACCTAACATAACTGT	0.493													18	50					0	0	0	0	T	52575977	T	T	52575977	2	4	82	1	0	0	0	0	0	0	0	1	2	349	13	5		5	A1CF	10	52575977	Silent	SNP	A	TCGA-CN-6988-01A-11D-1912-08	35433804	52575977	82958770	98	16368											
TET1	80312	broad.mit.edu	37	chr10	70406098	70406098	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgggcaattttgtccacaTgattttcctactgtatttgg	7	19	8	7	0	0	1	0	1	0	0	2	1	2	1	2	2	1	2	2	2	3	8			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr10:70406098T>C	uc001jok.3	+	4	4117	c.3612T>C	c.(3610-3612)CAT>CAC	p.H1204H		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1204					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TTTGTCCACATGATTTTCCTA	0.388													17	45					0	0	0	0	C	70406098	C	C	70406098	2	2	82	1	0	0	0	0	0	0	0	1	15835	1461	51	5		5	TET1	10	70406098	Silent	SNP	T	TCGA-CN-6988-01A-11D-1912-08	17830121	70406098	65128649	99	16369											
ANXA7	310	broad.mit.edu	37	chr10	75158106	75158106	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccactaggataaggatacTgaccagaagggggaaaagat	17	5	13	6	0	0	3	0	1	0	2	0	6	0	6	2	4	2	0	2	4	6	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr10:75158106T>C	uc001jtz.2	-	3	165	c.92A>G	c.(91-93)CAG>CGG	p.Q31R	ANXA7_uc001jua.2_Missense_Mutation_p.Q31R|ANXA7_uc001jub.2_5'UTR|ANXA7_uc010qki.1_5'UTR|ANXA7_uc009xre.2_Intron|ANXA7_uc009xrf.1_Missense_Mutation_p.Q31R	NM_004034	NP_004025	P20073	ANXA7_HUMAN	annexin VII isoform 2	31	Repeat-rich region.						calcium ion binding|calcium-dependent phospholipid binding|calcium-dependent protein binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					ATAAGGATACTGACCAGAAGG	0.468													11	19					0	0	0	0	C	75158106	C	C	75158106	3	2	82	1	0	0	0	0	1	0	0	0	723	1580	55	5	1422	5	ANXA7	10	75158106	Missense_Mutation	SNP	T	TCGA-CN-6988-01A-11D-1912-08	4752008	75158106	60376641	100	16370											
PANK1	53354	broad.mit.edu	37	chr10	91353635	91353635	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccgtaaatgtccttcacCagtttatcaacattggtgct	9	14	6	12	1	2	0	2	0	0	0	4	0	4	0	4	1	2	3	4	1	4	5			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr10:91353635C>A	uc001kgp.1	-	4	1578	c.1422G>T	c.(1420-1422)CTG>CTT	p.L474L	PANK1_uc001kgn.1_Silent_p.L249L|PANK1_uc001kgo.1_Intron|PANK1_uc009xtu.1_Silent_p.L276L|uc001kgq.1_5'Flank|MIR107_hsa-mir-107|MI0000114_5'Flank	NM_148977	NP_683878	Q8TE04	PANK1_HUMAN	pantothenate kinase 1 isoform alpha	474					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity				0					Bezafibrate(DB01393)	TGTCCTTCACCAGTTTATCAA	0.448													6	135					0.00116845	0.00431095	1	0	A	91353635	A	A	91353635	2	1	82	1	0	0	0	0	0	0	0	1	11470	581	21	4		4	PANK1	10	91353635	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	16195529	91353635	44181112	101	16371											
NSMCE4A	54780	broad.mit.edu	37	chr10	123719881	123719881	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtatcatttacctattactGgcagtcggtcttggtcaagt	9	15	9	8	1	3	0	2	0	1	0	4	0	3	0	1	3	2	2	1	3	5	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr10:123719881G>A	uc001lfs.2	-	8	1010	c.980C>T	c.(979-981)CCA>CTA	p.P327L	NSMCE4A_uc009xzv.2_Missense_Mutation_p.P327L|NSMCE4A_uc001lft.2_Missense_Mutation_p.P168L|NSMCE4A_uc010qtu.1_Missense_Mutation_p.P168L	NM_017615	NP_060085	Q9NXX6	NSE4A_HUMAN	non-SMC element 4 homolog A	327											0		all_neural(114;0.138)|Glioma(114;0.222)				ACCTATTACTGGCAGTCGGTC	0.289													9	25					0	0	0	0	A	123719881	A	A	123719881	3	1	82	1	0	0	0	0	1	0	0	0	10731	1348	47	4	189	4	NSMCE4A	10	123719881	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	32366246	123719881	11814866	102	16372											
ANO5	203859	broad.mit.edu	37	chr11	22296276	22296276	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcaccttcggaaaaacgAgacttcatcacttgcaggtg	12	9	9	11	2	2	1	2	0	0	1	3	3	2	2	1	2	3	2	1	2	2	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr11:22296276A>T	uc001mqi.2	+	20	2714	c.2397A>T	c.(2395-2397)CGA>CGT	p.R799R	ANO5_uc001mqj.2_Silent_p.R798R	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	799	Extracellular (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						CGGAAAAACGAGACTTCATCA	0.373													14	28					0	0	0	0	T	22296276	T	T	22296276	2	4	82	1	0	0	0	0	0	0	0	1	700	291	11	5		5	ANO5	11	22296276	Silent	SNP	A	TCGA-CN-6988-01A-11D-1912-08		22296276	112710240	103	16373											
AMBRA1	55626	broad.mit.edu	37	chr11	46439569	46439569	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgacatgtctccgctggtCggcaggcatgggataaagga	10	8	14	9	2	1	1	0	1	1	0	3	3	1	3	1	5	0	3	1	5	2	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr11:46439569C>A	uc010rgu.1	-	15	3370	c.3010G>T	c.(3010-3012)GAC>TAC	p.D1004Y	AMBRA1_uc010rgt.1_Missense_Mutation_p.D570Y|AMBRA1_uc009ylc.1_Missense_Mutation_p.D975Y|AMBRA1_uc001ncu.1_Missense_Mutation_p.D914Y|AMBRA1_uc001ncv.2_Missense_Mutation_p.D1007Y|AMBRA1_uc001ncw.2_Missense_Mutation_p.D885Y|AMBRA1_uc001ncx.2_Missense_Mutation_p.D944Y	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	1004					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		CTCCGCTGGTCGGCAGGCATG	0.488													21	44					3.5997e-14	1.55765e-13	1	0	A	46439569	A	A	46439569	3	1	82	1	0	0	0	0	1	0	0	0	565	884	31	3	902	3	AMBRA1	11	46439569	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	24143293	46439569	88566947	104	16374											
C11orf30	56946	broad.mit.edu	37	chr11	76253279	76253279	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcagccatcgctcccagccCcaacagccttcccagcccca	8	5	6	22	1	1	0	1	0	0	0	4	0	3	0	8	0	5	1	8	0	1	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr11:76253279C>T	uc001oxl.2	+	18	2720	c.2577C>T	c.(2575-2577)CCC>CCT	p.P859P	C11orf30_uc001oxm.2_Silent_p.P761P|C11orf30_uc010rsb.1_Silent_p.P874P|C11orf30_uc010rsc.1_Silent_p.P860P|C11orf30_uc001oxn.2_Silent_p.P860P|C11orf30_uc010rsd.1_Silent_p.P768P|C11orf30_uc001oxo.1_Silent_p.P213P|C11orf30_uc010rse.1_Silent_p.P106P|C11orf30_uc001oxp.2_5'UTR	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	859					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						GCTCCCAGCCCCAACAGCCTT	0.517													92	85					0	0	0	0	T	76253279	T	T	76253279	2	4	82	1	0	0	0	0	0	0	0	1	1642	610	22	4		4	C11orf30	11	76253279	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	29813710	76253279	58753237	105	16375											
GRM5	2915	broad.mit.edu	37	chr11	88386529	88386529	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgccaccaacagcttctcgCtgatatccatctgtcacatc	10	11	5	15	1	3	1	1	1	2	0	6	1	4	1	3	0	3	2	3	0	2	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr11:88386529C>A	uc001pcq.2	-	3	1154	c.954G>T	c.(952-954)CAG>CAT	p.Q318H	GRM5_uc009yvm.2_Missense_Mutation_p.Q318H	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	318	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CAGCTTCTCGCTGATATCCAT	0.453													17	79					1.67942e-08	6.80503e-08	1	0	A	88386529	A	A	88386529	3	1	82	1	0	0	0	0	1	0	0	0	6839	796	28	4	2712	4	GRM5	11	88386529	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	12133250	88386529	46619987	106	16376											
MTMR2	8898	broad.mit.edu	37	chr11	95580901	95580901	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatatgttctagccaatgagTagattccaagttagacaacc	15	11	7	8	0	1	3	0	1	1	2	2	3	2	3	3	0	2	3	3	0	8	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr11:95580901T>C	uc001pfu.2	-	10	1409	c.1156A>G	c.(1156-1158)ACT>GCT	p.T386A	MTMR2_uc001pfv.2_Missense_Mutation_p.T314A|MTMR2_uc001pfs.2_Missense_Mutation_p.T314A|MTMR2_uc001pft.2_Missense_Mutation_p.T314A|MTMR2_uc010ruj.1_Missense_Mutation_p.T369A	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	386	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGCCAATGAGTAGATTCCAAG	0.358													22	65					0	0	0	0	C	95580901	C	C	95580901	3	2	82	1	0	0	0	0	1	0	0	0	9997	1638	57	5	799	5	MTMR2	11	95580901	Missense_Mutation	SNP	T	TCGA-CN-6988-01A-11D-1912-08	7194372	95580901	39425615	107	16377											
PPP2R1B	5519	broad.mit.edu	37	chr11	111636073	111636074	+	In_Frame_Ins	INS	-	ATT	ATT																															ctactccaagtgctagggcaINSattgttgataacttcttaat																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr11:111636073_111636074insATT	uc001plx.1	-	2	233_234	c.149_150insAAT	c.(148-150)ATT>ATAATT	p.50_50I>II	PPP2R1B_uc001plw.1_In_Frame_Ins_p.50_50I>II|PPP2R1B_uc010rwi.1_Intron|PPP2R1B_uc010rwj.1_5'UTR|PPP2R1B_uc010rwk.1_In_Frame_Ins_p.50_50I>II|PPP2R1B_uc010rwl.1_In_Frame_Ins_p.50_50I>II	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	50	HEAT 1.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		GTGCTAGGGCAATTGTTGATAA	0.361													---	---	---								ATT	111636074	ATT	ATT	111636073	7	5	82	1	0	1	1	0	0	0	0	0	12443	126	5	0	1934	0	PPP2R1B	11	111636073	In_Frame_Ins	INS	-	TCGA-CN-6988-01A-11D-1912-08	16055172	111636073	23370443	108	16378											
SIDT2	51092	broad.mit.edu	37	chr11	117052527	117052527	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcttcgggccataggtttCagcgcaagtacctctaccaa	9	10	9	13	2	2	0	1	0	1	0	3	0	2	0	3	2	4	4	3	2	5	5			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr11:117052527C>G	uc001pqh.1	+	3	351	c.310C>G	c.(310-312)CAG>GAG	p.Q104E	SIDT2_uc010rxe.1_Missense_Mutation_p.Q104E|SIDT2_uc001pqg.2_Missense_Mutation_p.Q104E|SIDT2_uc001pqi.1_Missense_Mutation_p.Q104E	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	104	Extracellular (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		CCATAGGTTTCAGCGCAAGTA	0.592											OREG0021368	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	46					0	0	0	0	G	117052527	G	G	117052527	3	3	82	1	0	0	0	0	1	0	0	0	14368	827	29	2	320	2	SIDT2	11	117052527	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	5416454	117052527	17953989	109	16379											
SORL1	6653	broad.mit.edu	37	chr11	121454271	121454271	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggactgccaggatggttccGatgaggatccagtcaactgt	9	9	13	10	2	1	1	1	1	0	0	3	5	3	4	3	4	2	1	3	4	1	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr11:121454271G>T	uc001pxx.2	+	26	3765	c.3685G>T	c.(3685-3687)GAT>TAT	p.D1229Y	SORL1_uc010rzp.1_Missense_Mutation_p.D75Y	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1229	Extracellular (Potential).|LDL-receptor class A 4.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GGATGGTTCCGATGAGGATCC	0.597													27	28					6.12954e-19	2.77213e-18	1	0	T	121454271	T	T	121454271	3	4	82	1	0	0	0	0	1	0	0	0	14998	1058	37	3	3787	3	SORL1	11	121454271	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	4401744	121454271	13552245	110	16380											
IQSEC3	440073	broad.mit.edu	37	chr12	266231	266231	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acttctccagcatggagctgGacgaggccctgcgcaagttc	8	8	12	13	2	1	0	0	0	1	0	3	3	1	2	2	3	3	4	2	3	1	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:266231G>A	uc001qhw.1	+	3	1291	c.1285G>A	c.(1285-1287)GAC>AAC	p.D429N	IQSEC3_uc001qhu.1_Missense_Mutation_p.D429N	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	732	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CATGGAGCTGGACGAGGCCCT	0.637													6	11					0	0	0	0	A	266231	A	A	266231	3	1	82	1	0	0	0	0	1	0	0	0	7858	1174	41	2	2216	2	IQSEC3	12	266231	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08		266231	133585664	111	16381											
C1S	716	broad.mit.edu	37	chr12	7175808	7175808	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgggtgaatgaggtgctggGcccggagctgccgaaatgtg	7	8	18	8	2	0	2	0	2	0	0	0	4	0	3	2	4	3	2	2	4	2	0			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:7175808G>A	uc001qsj.2	+	14	1963	c.1244G>A	c.(1243-1245)GGC>GAC	p.G415D	C1S_uc001qsk.2_Missense_Mutation_p.G415D|C1S_uc001qsl.2_Missense_Mutation_p.G415D|C1S_uc009zfr.2_Missense_Mutation_p.G248D|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	415	Sushi 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GAGGTGCTGGGCCCGGAGCTG	0.547													74	76					0	0	0	0	A	7175808	A	A	7175808	3	1	82	1	0	0	0	0	1	0	0	0	1983	1203	42	4	1282	4	C1S	12	7175808	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	6909577	7175808	126676087	112	16382											
SLC2A3	6515	broad.mit.edu	37	chr12	8083916	8083916	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccgcagggcagtaggcgaGatctctccaatgtacatggg	9	7	13	12	2	1	1	0	0	1	1	3	2	2	1	3	3	1	4	3	3	3	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:8083916G>A	uc001qtr.2	-	4	697	c.435C>T	c.(433-435)ATC>ATT	p.I145I	SLC2A3_uc001qts.2_Silent_p.I145I	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	145	Helical; Name=4; (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		CAGTAGGCGAGATCTCTCCAA	0.517													38	47					0	0	0	0	A	8083916	A	A	8083916	2	1	82	1	0	0	0	0	0	0	0	1	14609	932	33	2		2	SLC2A3	12	8083916	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	908108	8083916	125767979	113	16383											
SLCO1B1	10599	broad.mit.edu	37	chr12	21377659	21377659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcttctcctattacaggagGaattctagctccaatatatt	11	15	5	10	0	3	0	0	0	3	0	5	2	4	2	2	2	2	1	2	2	7	8			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:21377659G>A	uc001req.3	+	14	1855	c.1751G>A	c.(1750-1752)GGA>GAA	p.G584E		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	584	Helical; Name=11; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity	p.G584G(1)		ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	ATTACAGGAGGAATTCTAGCT	0.353													44	64					0	0	0	0	A	21377659	A	A	21377659	3	1	82	1	0	0	0	0	1	0	0	0	14787	1174	41	2	1801	2	SLCO1B1	12	21377659	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	13293743	21377659	112474236	114	16384											
HDAC7	51564	broad.mit.edu	37	chr12	48191248	48191248	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagctgctgagcatggagcGggtggctccttccgtctcca	7	9	13	12	2	1	1	0	1	1	0	4	2	3	2	3	3	4	4	3	3	1	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:48191248G>A	uc009zkv.1	-	4	594	c.379C>T	c.(379-381)CGC>TGC	p.R127C	HDAC7_uc010slo.1_Missense_Mutation_p.R166C|HDAC7_uc001rqj.3_Missense_Mutation_p.R166C|HDAC7_uc001rqk.3_Missense_Mutation_p.R149C			Q8WUI4	HDAC7_HUMAN	Synthetic construct DNA, clone: pF1KB0470, Homo sapiens HDAC7 gene for histone deacetylase 7, without stop codon, in Flexi system.	127	Interaction with MEF2A (By similarity).|Transcription repression 1 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		AGCATGGAGCGGGTGGCTCCT	0.622													24	50					0	0	0	0	A	48191248	A	A	48191248	3	1	82	1	0	0	0	0	1	0	0	0	7051	1116	39	1	2563	1	HDAC7	12	48191248	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	26813589	48191248	85660647	115	16385											
AQP6	363	broad.mit.edu	37	chr12	50368216	50368216	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagccgtcagacatcaggctCcccggccaccatgattggga	9	6	11	15	2	2	2	2	1	0	1	3	3	3	3	5	3	1	1	5	3	0	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:50368216C>T	uc001rvr.1	+	2	849	c.512C>T	c.(511-513)TCC>TTC	p.S171F	AQP6_uc001rvp.1_5'UTR|AQP6_uc001rvq.1_RNA	NM_001652	NP_001643	Q13520	AQP6_HUMAN	aquaporin 6	171	Helical; (Potential).				excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity				0						ACATCAGGCTCCCCGGCCACC	0.627											OREG0021809	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	36					0	0	0	0	T	50368216	T	T	50368216	3	4	82	1	0	0	0	0	1	0	0	0	830	855	30	2	518	2	AQP6	12	50368216	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	2176968	50368216	83483679	116	16386											
STAT2	6773	broad.mit.edu	37	chr12	56740685	56740685	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtagaaaggtgccagacatGgtcttcttcagcagccggcg	10	8	13	10	2	3	2	1	0	2	2	3	2	3	2	2	3	3	2	2	3	2	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:56740685G>A	uc001slc.2	-	20	1857	c.1779C>T	c.(1777-1779)ACC>ACT	p.T593T	STAT2_uc001slb.2_Silent_p.T135T|STAT2_uc001sld.2_Silent_p.T589T	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	593	SH2.				interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TGCCAGACATGGTCTTCTTCA	0.602													50	57					0	0	0	0	A	56740685	A	A	56740685	2	1	82	1	0	0	0	0	0	0	0	1	15331	1335	47	4		4	STAT2	12	56740685	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	6372469	56740685	77111210	117	16387											
ARHGAP9	64333	broad.mit.edu	37	chr12	57868454	57868454	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggaccactgccaagttccCgctcacccgataaatgccat	10	8	7	16	2	1	0	1	0	0	0	2	2	2	1	5	1	2	2	5	1	3	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:57868454C>A	uc001sod.2	-	17	2147	c.1954G>T	c.(1954-1956)GGG>TGG	p.G652W	ARHGAP9_uc001sny.2_RNA|ARHGAP9_uc001snz.2_Missense_Mutation_p.G378W|ARHGAP9_uc001soa.2_Missense_Mutation_p.G251W|ARHGAP9_uc001sob.2_Missense_Mutation_p.G562W|ARHGAP9_uc001soc.2_Missense_Mutation_p.G562W|ARHGAP9_uc001soe.1_Missense_Mutation_p.G641W	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	581	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			GCCAAGTTCCCGCTCACCCGA	0.507													5	109					0.00116845	0.00431095	1	0	A	57868454	A	A	57868454	3	1	82	1	0	0	0	0	1	0	0	0	889	652	23	3	531	3	ARHGAP9	12	57868454	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	1127769	57868454	75983441	118	16388											
PPP1R12A	4659	broad.mit.edu	37	chr12	80211242	80211242	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgttgtaacagctacaggagCtgcttgtgtactagaagtgt	10	13	12	6	0	0	1	0	0	0	1	0	2	0	2	0	1	6	6	0	1	5	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:80211242C>T	uc001syz.2	-	9	1438	c.1171G>A	c.(1171-1173)GCT>ACT	p.A391T	PPP1R12A_uc010suc.1_Missense_Mutation_p.A304T|PPP1R12A_uc001sza.2_Missense_Mutation_p.A391T|PPP1R12A_uc010sud.1_Missense_Mutation_p.A391T|PPP1R12A_uc001szb.2_Missense_Mutation_p.A391T|PPP1R12A_uc001szc.2_Missense_Mutation_p.A391T	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	391						contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						GCTACAGGAGCTGCTTGTGTA	0.358													6	21					0	0	0	0	T	80211242	T	T	80211242	3	4	82	1	0	0	0	0	1	0	0	0	12414	797	28	4	1989	4	PPP1R12A	12	80211242	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	22342788	80211242	53640653	119	16389											
C12orf42	374470	broad.mit.edu	37	chr12	103695967	103695967	+	Frame_Shift_Del	DEL	T	-	-																															cgccgggttgggcgggggggTgctgaggagcaaacctttat																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:103695967delT	uc001tjt.2	-	6	1090	c.1002delA	c.(1000-1002)GCAfs	p.A334fs	C12orf42_uc001tjs.2_Intron|C12orf42_uc009zuf.1_Frame_Shift_Del_p.A334fs|C12orf42_uc001tju.2_Frame_Shift_Del_p.A239fs	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	334										ovary(1)|central_nervous_system(1)	2						GGCGGGGGGGTGCTGAGGAGC	0.582													---	---	---								-	103695967	-	-	103695967	7	5	82	1	0	1	0	1	0	0	0	0	1694	1683	59	0	84	0	C12orf42	12	103695967	Frame_Shift_Del	DEL	T	TCGA-CN-6988-01A-11D-1912-08	23484725	103695967	30155928	120	16390											
WSCD2	9671	broad.mit.edu	37	chr12	108589613	108589613	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccggaatgatcccactatgGccaagctctggttcaaattc	10	11	8	12	1	2	1	1	1	1	0	5	2	4	2	3	3	1	2	3	3	4	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:108589613G>T	uc001tms.2	+	2	748	c.4G>T	c.(4-6)GCC>TCC	p.A2S	WSCD2_uc001tmt.2_Missense_Mutation_p.A2S	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	2						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						TCCCACTATGGCCAAGCTCTG	0.562													13	40					0.00136819	0.00502149	1	0	T	108589613	T	T	108589613	3	4	82	1	0	0	0	0	1	0	0	0	17475	1203	42	4	6	4	WSCD2	12	108589613	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	4893646	108589613	25262282	121	16391											
DYNLL1	8655	broad.mit.edu	37	chr12	120934324	120934324	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcgctggagaaatacaacAtagagaaggacattgcggct	15	6	13	7	2	0	2	0	0	0	2	0	5	0	3	0	4	3	2	0	4	5	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr12:120934324A>G	uc001tyj.2	+	2	354	c.100A>G	c.(100-102)ATA>GTA	p.I34V	uc001tyk.1_5'Flank|DYNLL1_uc001tyl.2_Missense_Mutation_p.I34V|DYNLL1_uc001tym.2_Missense_Mutation_p.I34V	NM_001037494	NP_001032583	P63167	DYL1_HUMAN	dynein light chain 1	34					actin cytoskeleton organization|activation of pro-apoptotic gene products|anatomical structure morphogenesis|female gamete generation|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|microtubule-based process|negative regulation of phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	centrosome|cytoplasmic dynein complex|cytosol|microtubule|mitochondrion|nucleus|plasma membrane	motor activity|protein binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAAATACAACATAGAGAAGGA	0.577													20	85					0	0	0	0	G	120934324	G	G	120934324	3	3	82	1	0	0	0	0	1	0	0	0	4870	217	8	5	102	5	DYNLL1	12	120934324	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	12344711	120934324	12917571	122	16392											
KPNA3	3839	broad.mit.edu	37	chr13	50293956	50293956	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacataaagctggcaaaatCtgaggaaagaaaataaacaa	23	5	7	6	0	1	2	0	1	1	1	1	3	1	3	0	2	2	2	0	2	10	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr13:50293956C>G	uc001vdj.2	-	10	1142	c.727_splice	c.e10-1	p.I243_splice		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3						interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		CTGGCAAAATCTGAGGAAAGA	0.333													17	4					0	0	0	0	G	50293956	G	G	50293956	5	3	82	1	0	0	0	0	0	0	1	0	8470	927	32	2	871	2	KPNA3	13	50293956	Splice_Site	SNP	C	TCGA-CN-6988-01A-11D-1912-08		50293956	64875922	123	16393											
MYO16	23026	broad.mit.edu	37	chr13	109496738	109496738	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcaagacagtttgttggaaaAagacattatgttcaaagatg	16	11	10	4	0	1	3	1	0	0	3	1	4	1	4	0	1	0	4	0	1	5	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr13:109496738A>C	uc001vqt.1	+	10	1205	c.1079A>C	c.(1078-1080)AAA>ACA	p.K360T	MYO16_uc010agk.1_Missense_Mutation_p.K382T|MYO16_uc001vqu.1_Missense_Mutation_p.K160T	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	360					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTGTTGGAAAAAGACATTATG	0.413													9	27					0	0	0	0	C	109496738	C	C	109496738	3	2	82	1	0	0	0	0	1	0	0	0	10117	14	1	5	1113	5	MYO16	13	109496738	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	59202782	109496738	5673140	124	16394											
MPP5	64398	broad.mit.edu	37	chr14	67784174	67784175	+	Frame_Shift_Ins	INS	-	T	T																															agaagaggaaaaaggttttaINStataatgccaataaaaatga																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr14:67784174_67784175insT	uc001xjc.2	+	11	1813_1814	c.1347_1348insT	c.(1345-1350)TTATATfs	p.L449fs	MPP5_uc001xjd.2_Frame_Shift_Ins_p.L415fs|ATP6V1D_uc001xje.2_Intron	NM_022474	NP_071919	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5	449_450					tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			ovary(1)	1				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		AAAAGGTTTTATATAATGCCAA	0.342													---	---	---								T	67784175	T	T	67784174	7	5	82	1	0	1	1	0	0	0	0	0	9790	446	16	0	1381	0	MPP5	14	67784174	Frame_Shift_Ins	INS	-	TCGA-CN-6988-01A-11D-1912-08		67784174	39565366	125	16395											
GABRB3	2562	broad.mit.edu	37	chr15	26812872	26812872	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaagctcagtgacagtcgagGataggcacctatgggaaaca	15	6	12	8	1	1	1	1	1	0	0	2	4	1	3	1	3	2	2	1	3	4	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr15:26812872G>T	uc001zaz.2	-	7	833	c.691C>A	c.(691-693)CCT>ACT	p.P231T	GABRB3_uc010uae.1_Missense_Mutation_p.P146T|GABRB3_uc001zba.2_Missense_Mutation_p.P231T|GABRB3_uc001zbb.2_Missense_Mutation_p.P287T	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	231	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GACAGTCGAGGATAGGCACCT	0.433													12	22					3.27435e-08	1.31915e-07	1	0	T	26812872	T	T	26812872	3	4	82	1	0	0	0	0	1	0	0	0	6202	1174	41	2	742	2	GABRB3	15	26812872	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08		26812872	75718520	126	16396											
CHP	11261	broad.mit.edu	37	chr15	41549177	41549177	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccggatcatcaatgccttCtttccagaggggtgagtcag	9	10	12	10	1	4	2	3	1	1	1	5	4	5	3	3	3	1	0	3	3	1	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr15:41549177C>T	uc001znl.2	+	3	354	c.210C>T	c.(208-210)TTC>TTT	p.F70F		NM_007236	NP_009167	Q99653	CHP1_HUMAN	calcium binding protein P22	70	EF-hand 2.				potassium ion transport|small GTPase mediated signal transduction		potassium channel regulator activity			ovary(1)	1		all_cancers(109;1.19e-18)|all_epithelial(112;5.87e-16)|Lung NSC(122;8.86e-12)|all_lung(180;2.47e-10)|Melanoma(134;0.0574)|Colorectal(260;0.0946)|Ovarian(310;0.143)		GBM - Glioblastoma multiforme(113;1.68e-06)|LUSC - Lung squamous cell carcinoma(244;0.008)|Lung(196;0.00802)|BRCA - Breast invasive adenocarcinoma(123;0.169)		TCAATGCCTTCTTTCCAGAGG	0.458													16	39					0	0	0	0	T	41549177	T	T	41549177	2	4	82	1	0	0	0	0	0	0	0	1	3381	912	32	2		2	CHP	15	41549177	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	14736305	41549177	60982215	127	16397											
VPS39	23339	broad.mit.edu	37	chr15	42465981	42465981	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcttctggcagaagaggtTgaaggcatacaagttcttga	12	10	12	7	1	2	4	0	2	2	2	2	4	2	4	0	3	1	5	0	3	4	5			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr15:42465981T>G	uc001zpd.2	-	12	1214	c.1063A>C	c.(1063-1065)AAC>CAC	p.N355H	VPS39_uc001zpc.2_Missense_Mutation_p.N344H	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	355					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		CAGAAGAGGTTGAAGGCATAC	0.403													46	41					0	0	0	0	G	42465981	G	G	42465981	3	3	82	1	0	0	0	0	1	0	0	0	17277	1812	63	5	1657	5	VPS39	15	42465981	Missense_Mutation	SNP	T	TCGA-CN-6988-01A-11D-1912-08	916804	42465981	60065411	128	16398											
ONECUT1	3175	broad.mit.edu	37	chr15	53081052	53081052	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcctccggaaggtctcccGgccggatttgagtttgctcc	5	11	11	14	3	1	1	0	1	1	0	5	3	4	3	5	4	1	2	5	4	1	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr15:53081052G>A	uc002aci.1	-	1	1158	c.1030C>T	c.(1030-1032)CGG>TGG	p.R344W		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	344	CUT.				endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		AAGGTCTCCCGGCCGGATTTG	0.672													21	43					0	0	0	0	A	53081052	A	A	53081052	3	1	82	1	0	0	0	0	1	0	0	0	10922	1115	39	1	375	1	ONECUT1	15	53081052	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	10615071	53081052	49450340	129	16399											
MYO1E	4643	broad.mit.edu	37	chr15	59445837	59445837	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaatccaggctctctggcGtctgtgacactcggtctgaa	8	10	12	11	2	3	2	0	2	3	0	6	3	4	3	1	4	0	1	1	4	2	0			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr15:59445837G>A	uc002aga.2	-	26	3404	c.3032C>T	c.(3031-3033)ACG>ATG	p.T1011M		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	1011					actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		GCTCTCTGGCGTCTGTGACAC	0.582													29	68					0	0	0	0	A	59445837	A	A	59445837	3	1	82	1	0	0	0	0	1	0	0	0	10125	1145	40	1	306	1	MYO1E	15	59445837	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	6364785	59445837	43085555	130	16400											
HERC1	8925	broad.mit.edu	37	chr15	63950807	63950807	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagaagaacctgagcagcagCagtcactctccttaaagcca	14	6	8	13	0	2	3	1	1	1	2	3	3	2	3	3	0	5	3	3	0	4	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr15:63950807C>T	uc002amp.2	-	48	9683	c.9535G>A	c.(9535-9537)GCT>ACT	p.A3179T		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3179					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TGAGCAGCAGCAGTCACTCTC	0.493													13	36					0	0	0	0	T	63950807	T	T	63950807	3	4	82	1	0	0	0	0	1	0	0	0	7096	710	25	4	5174	4	HERC1	15	63950807	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	4504970	63950807	38580585	131	16401											
SLCO3A1	28232	broad.mit.edu	37	chr15	92459366	92459366	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgggcaccggccgcgcctGatcggctgcggcggcatcgt	3	5	17	16	9	0	1	0	1	0	0	2	1	0	1	3	5	1	3	3	5	0	0			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr15:92459366G>T	uc002bqx.2	+	2	525	c.324G>T	c.(322-324)CTG>CTT	p.L108L	SLCO3A1_uc002bqy.2_Silent_p.L108L|SLCO3A1_uc010boc.1_RNA|SLCO3A1_uc002bqz.1_Silent_p.L50L	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	108	Helical; Name=3; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			GGCCGCGCCTGATCGGCTGCG	0.682													9	15					7.48243e-07	2.93027e-06	1	0	T	92459366	T	T	92459366	2	4	82	1	0	0	0	0	0	0	0	1	14792	1277	45	2		2	SLCO3A1	15	92459366	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	28508559	92459366	10072026	132	16402											
ABCA3	21	broad.mit.edu	37	chr16	2339465	2339465	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttgacagcggtgcgctcCtcctcgatgagggctccaat	7	9	12	13	3	0	2	0	2	0	0	4	3	3	2	3	2	3	3	3	2	1	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr16:2339465C>T	uc002cpy.1	-	20	3382	c.2670G>A	c.(2668-2670)GAG>GAA	p.E890E	ABCA3_uc010bsk.1_Silent_p.E832E|ABCA3_uc010bsl.1_Silent_p.E890E	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	890					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CGGTGCGCTCCTCCTCGATGA	0.677													10	4					0	0	0	0	T	2339465	T	T	2339465	2	4	82	1	0	0	0	0	0	0	0	1	33	680	24	4		4	ABCA3	16	2339465	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08		2339465	88015288	133	16403											
CREBBP	1387	broad.mit.edu	37	chr16	3900396	3900396	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccagcacgctgctcgaggCgccctgcatggctggagtag	7	6	15	13	3	0	0	0	0	0	0	1	2	0	1	2	3	4	6	2	3	1	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr16:3900396C>G	uc002cvv.2	-	2	904	c.700G>C	c.(700-702)GCC>CCC	p.A234P	CREBBP_uc002cvw.2_Missense_Mutation_p.A234P	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	234	Interaction with SRCAP.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CTGCTCGAGGCGCCCTGCATG	0.622			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				3	62					0	0	0	0	G	3900396	G	G	3900396	3	3	82	1	0	0	0	0	1	0	0	0	3876	768	27	3	6748	3	CREBBP	16	3900396	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	1560931	3900396	86454357	134	16404											
PALB2	79728	broad.mit.edu	37	chr16	23646937	23646937	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgggcagttggccacttttActtatagctttatttacaag	9	16	9	7	0	0	0	0	0	0	0	0	0	0	0	1	2	3	3	1	2	6	9			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr16:23646937A>G	uc002dlx.1	-	4	1130	c.930T>C	c.(928-930)AGT>AGC	p.S310S		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	310	Interaction with BRCA1.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		GGCCACTTTTACTTATAGCTT	0.343			F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				43	88					0	0	0	0	G	23646937	G	G	23646937	2	3	82	1	0	0	0	0	0	0	0	1	11460	388	14	5		5	PALB2	16	23646937	Silent	SNP	A	TCGA-CN-6988-01A-11D-1912-08	19746541	23646937	66707816	135	16405											
SLC6A2	6530	broad.mit.edu	37	chr16	55730222	55730222	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgttgtgtttttcgtcatGctcctggcgctgggccttga	2	16	13	10	2	1	1	1	1	0	0	3	1	2	1	2	2	1	5	2	2	0	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr16:55730222G>A	uc002eif.2	+	9	1344	c.1233G>A	c.(1231-1233)ATG>ATA	p.M411I	SLC6A2_uc010ccd.2_Missense_Mutation_p.M411I|SLC6A2_uc002eig.2_Missense_Mutation_p.M411I|SLC6A2_uc002eih.2_Missense_Mutation_p.M411I|SLC6A2_uc002eii.2_Missense_Mutation_p.M306I|SLC6A2_uc002eij.2_Missense_Mutation_p.M125I	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	411	Helical; Name=8; (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	TTTTCGTCATGCTCCTGGCGC	0.542													27	92					0	0	0	0	A	55730222	A	A	55730222	3	1	82	1	0	0	0	0	1	0	0	0	14747	1319	46	4	1354	4	SLC6A2	16	55730222	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	32083285	55730222	34624531	136	16406											
CDH11	1009	broad.mit.edu	37	chr16	65016141	65016141	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	attgctgataaacttcgggtCgatgtgcacgttggctgcct	7	13	12	9	3	0	1	0	1	0	0	2	2	0	1	1	2	4	4	1	2	2	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr16:65016141C>G	uc002eoi.2	-	8	1497	c.1063G>C	c.(1063-1065)GAC>CAC	p.D355H	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Missense_Mutation_p.D355H|CDH11_uc010vin.1_Missense_Mutation_p.D229H|CDH11_uc002eok.1_RNA	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	355	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AACTTCGGGTCGATGTGCACG	0.468			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			18	78					0	0	0	0	G	65016141	G	G	65016141	3	3	82	1	0	0	0	0	1	0	0	0	3112	884	31	3	1351	3	CDH11	16	65016141	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	9285919	65016141	25338612	137	16407											
ADAMTS18	170692	broad.mit.edu	37	chr16	77327096	77327096	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctcggggagggtttctgcGgcagagcccttgcagaggag	6	8	17	10	2	2	2	0	0	2	2	3	4	2	4	1	5	3	3	1	5	0	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr16:77327096G>C	uc002ffc.3	-	20	3485	c.3066C>G	c.(3064-3066)GCC>GCG	p.A1022A	ADAMTS18_uc010chc.1_Silent_p.A610A	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1022	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GGGTTTCTGCGGCAGAGCCCT	0.557													46	39					0	0	0	0	C	77327096	C	C	77327096	2	2	82	1	0	0	0	0	0	0	0	1	263	1103	39	3		3	ADAMTS18	16	77327096	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	12310955	77327096	13027657	138	16408											
AMAC1L3	643664	broad.mit.edu	37	chr17	7386050	7386050	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccccgtgttgcccagtgaTctcccgagttggagttgtgt	4	12	12	13	2	1	1	0	1	1	0	2	3	1	2	5	1	1	3	5	1	0	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr17:7386050T>C	uc010cmj.1	+	2	862	c.747T>C	c.(745-747)GAT>GAC	p.D249D	ZBTB4_uc002ghd.3_Intron|POLR2A_uc002ghe.2_5'Flank|POLR2A_uc002ghf.3_5'Flank	NM_001102614	NP_001096084	P0C7Q6	AMCL3_HUMAN	acyl-malonyl condensing enzyme 1-like 3	249						integral to membrane					0		Prostate(122;0.173)				TGCCCAGTGATCTCCCGAGTT	0.632													5	68					0	0	0	0	C	7386050	C	C	7386050	2	2	82	1	0	0	0	0	0	0	0	1	561	1432	50	5		5	AMAC1L3	17	7386050	Silent	SNP	T	TCGA-CN-6988-01A-11D-1912-08		7386050	73809160	139	16409											
TP53	7157	broad.mit.edu	37	chr17	7578505	7578515	+	Frame_Shift_Del	DEL	GGGCAGGTCTT	-	-																															aatcaacccacagctgcacaGggcaggtcttggccagttgg																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr17:7578505_7578515delGGGCAGGTCTT	uc002gim.2	-	5	609_619	c.415_425delAAGACCTGCCC	c.(415-426)AAGACCTGCCCTfs	p.K139fs	TP53_uc002gig.1_Frame_Shift_Del_p.K139fs|TP53_uc002gih.2_Frame_Shift_Del_p.K139fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.K7fs|TP53_uc010cng.1_Frame_Shift_Del_p.K7fs|TP53_uc002gii.1_Frame_Shift_Del_p.K7fs|TP53_uc010cnh.1_Frame_Shift_Del_p.K139fs|TP53_uc010cni.1_Frame_Shift_Del_p.K139fs|TP53_uc002gij.2_Frame_Shift_Del_p.K139fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.K46fs|TP53_uc002gio.2_Frame_Shift_Del_p.K7fs|TP53_uc010vug.1_Frame_Shift_Del_p.K100fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	139_142	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> R (in a sporadic cancer; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C141Y(61)|p.T140I(12)|p.C141*(11)|p.C141R(10)|p.C141W(10)|p.K139N(8)|p.P142L(8)|p.K139K(7)|p.0?(7)|p.T140T(6)|p.K139fs*31(4)|p.C141C(4)|p.C141F(4)|p.K139fs*9(3)|p.P142H(3)|p.C141fs*29(3)|p.K139Q(2)|p.K139R(2)|p.K139E(2)|p.P142F(2)|p.P142A(2)|p.P142T(2)|p.P142S(2)|p.N131fs*27(2)|p.C141S(2)|p.P142fs*28(2)|p.C141fs*8(2)|p.K139*(2)|p.K139T(1)|p.L137_W146del10(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.F134_T140>S(1)|p.T140fs*9(1)|p.C141fs*34(1)|p.C141fs*30(1)|p.V73fs*9(1)|p.A138_V143delAKTCPV(1)|p.T140N(1)|p.K139fs*11(1)|p.K139fs*10(1)|p.T140fs*30(1)|p.A138fs*31(1)|p.A138_P142delAKTCP(1)|p.C135_T140delCQLAKT(1)|p.Q136_K139delQLAK(1)|p.C141A(1)|p.C141G(1)|p.C141_P142insXX(1)|p.K139_C141>N(1)|p.K139fs*29(1)|p.T140fs*28(1)|p.C141fs*5(1)|p.P142del(1)|p.P142fs*7(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCTGCACAGGGCAGGTCTTGGCCAGTTGG	0.573		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578515	-	-	7578505	7	5	82	1	0	1	0	1	0	0	0	0	16448	1000	35	0	873	0	TP53	17	7578505	Frame_Shift_Del	DEL	GGGCAGGTCTT	TCGA-CN-6988-01A-11D-1912-08	192455	7578505	73616705	140	16410											
TMEM132E	124842	broad.mit.edu	37	chr17	32953598	32953598	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatgccttccgggatgccCgggaagtcaagagctcctgc	7	8	13	13	2	1	1	1	0	0	1	3	3	3	3	4	2	5	2	4	2	2	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr17:32953598C>T	uc002hif.2	+	2	848	c.520C>T	c.(520-522)CGG>TGG	p.R174W		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	174	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCGGGATGCCCGGGAAGTCAA	0.716													15	12					0	0	0	0	T	32953598	T	T	32953598	3	4	82	1	0	0	0	0	1	0	0	0	16114	643	23	1	526	1	TMEM132E	17	32953598	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	25375093	32953598	48241612	141	16411											
ADAM11	4185	broad.mit.edu	37	chr17	42850673	42850673	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcatcgtcctggttgccatGgaaacatgggcagatgggga	9	8	15	9	2	0	1	0	0	0	1	2	3	1	3	2	5	2	3	2	5	1	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr17:42850673G>A	uc002ihh.2	+	11	870	c.870G>A	c.(868-870)ATG>ATA	p.M290I	ADAM11_uc010wjd.1_Missense_Mutation_p.M90I	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	290	Extracellular (Potential).|Peptidase M12B.				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				TGGTTGCCATGGAAACATGGG	0.622													25	93					0	0	0	0	A	42850673	A	A	42850673	3	1	82	1	0	0	0	0	1	0	0	0	235	1348	47	4	912	4	ADAM11	17	42850673	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	9897075	42850673	38344537	142	16412											
RAD51C	5889	broad.mit.edu	37	chr17	56770057	56770057	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgggatttggtgagtttccCgctgtctccagcggtgcggg	3	11	17	10	4	1	1	0	1	1	0	3	2	2	2	2	4	2	2	2	4	0	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr17:56770057C>G	uc002iwu.2	+	1	95	c.53C>G	c.(52-54)CCG>CGG	p.P18R	TEX14_uc002iwr.1_5'Flank|TEX14_uc002iws.1_5'Flank|TEX14_uc010dcz.1_5'Flank|TEX14_uc010dda.1_5'Flank|TEX14_uc010wnz.1_5'Flank|RAD51C_uc002iwt.1_Missense_Mutation_p.P18R|RAD51C_uc010woa.1_Missense_Mutation_p.P18R|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA|RAD51C_uc010wob.1_Intron	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	18					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTGAGTTTCCCGCTGTCTCCA	0.602								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				20	68					0	0	0	0	G	56770057	G	G	56770057	3	3	82	1	0	0	0	0	1	0	0	0	13053	652	23	3	55	3	RAD51C	17	56770057	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	13919384	56770057	24425153	143	16413											
MED13	9969	broad.mit.edu	37	chr17	60112835	60112835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataatctaccttgaaatgggCtattagactgttgagcaagg	13	12	10	6	0	1	3	0	2	1	1	1	3	1	3	1	2	2	3	1	2	6	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr17:60112835C>T	uc002izo.2	-	4	682	c.605G>A	c.(604-606)AGC>AAC	p.S202N		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	202					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TTGAAATGGGCTATTAGACTG	0.338													10	45					0	0	0	0	T	60112835	T	T	60112835	3	4	82	1	0	0	0	0	1	0	0	0	9483	797	28	4	6027	4	MED13	17	60112835	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	3342778	60112835	21082375	144	16414											
POLG2	11232	broad.mit.edu	37	chr17	62492731	62492731	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atacctgctccctgaacaccAccaccgaggtccaccattct	10	8	5	18	1	1	1	0	1	1	0	3	2	3	1	7	1	3	1	7	1	2	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr17:62492731A>G	uc002jei.2	-	1	439	c.356T>C	c.(355-357)GTG>GCG	p.V119A	POLG2_uc010deg.1_Missense_Mutation_p.V119A	NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	119				WWTSVVVFREQ -> MVDLGGGVHGA (in Ref. 5; AAC51321).	DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			CCTGAACACCACCACCGAGGT	0.602													28	47					0	0	0	0	G	62492731	G	G	62492731	3	3	82	1	0	0	0	0	1	0	0	0	12256	159	6	5	1133	5	POLG2	17	62492731	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08	2379896	62492731	18702479	145	16415											
DNAI2	64446	broad.mit.edu	37	chr17	72278070	72278070	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcccaaccctgagctggcCgagcagttcgtggagcggaa	9	6	14	12	3	0	1	0	1	0	0	1	4	0	3	3	3	5	3	3	3	2	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr17:72278070C>A	uc002jkf.2	+	2	213	c.114C>A	c.(112-114)GCC>GCA	p.A38A	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	38					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CTGAGCTGGCCGAGCAGTTCG	0.622									Kartagener_syndrome				32	185					4.31634e-10	1.81183e-09	1	0	A	72278070	A	A	72278070	2	1	82	1	0	0	0	0	0	0	0	1	4632	639	23	3		3	DNAI2	17	72278070	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	9785339	72278070	8917140	146	16416											
RECQL5	9400	broad.mit.edu	37	chr17	73625498	73625498	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtctccatcagttccgtggCcgtctggaacgggcaggagc	6	9	14	12	3	3	0	1	0	2	0	5	2	4	2	3	4	2	2	3	4	1	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr17:73625498C>T	uc010dgl.2	-	16	2161	c.2005G>A	c.(2005-2007)GCC>ACC	p.A669T	RECQL5_uc010dgk.2_Missense_Mutation_p.A642T|RECQL5_uc002jot.3_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	669					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			AGTTCCGTGGCCGTCTGGAAC	0.657								Other_identified_genes_with_known_or_suspected_DNA_repair_function					11	50					0	0	0	0	T	73625498	T	T	73625498	3	4	82	1	0	0	0	0	1	0	0	0	13268	739	26	4	990	4	RECQL5	17	73625498	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	1347428	73625498	7569712	147	16417											
DNAH17	8632	broad.mit.edu	37	chr17	76567831	76567831	+	5'Flank	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatggtggtttcaatggcGtgcaggagcaagttgtccag	9	11	15	6	1	1	1	1	1	0	0	2	2	2	2	1	4	2	4	1	4	2	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr17:76567831G>C	uc002jvv.1	-											RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TTTCAATGGCGTGCAGGAGCA	0.617													19	98					0	0	0	0	C	76567831	C	C	76567831	1	2	82	0	1	0	0	0	0	0	0	0	4623	1136	40	3		3	DNAH17	17	76567831	5'Flank	SNP	G	TCGA-CN-6988-01A-11D-1912-08	2942333	76567831	4627379	148	16418											
SMCHD1	23347	broad.mit.edu	37	chr18	2706416	2706416	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgccaattgcaaagctggatAggacagttgctgagaaagct	13	9	12	7	0	0	1	0	1	0	1	0	4	0	3	1	2	5	5	1	2	4	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr18:2706416A>G	uc002klm.3	+	15	2200	c.2011A>G	c.(2011-2013)AGG>GGG	p.R671G	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	671					chromosome organization		ATP binding				0						AAAGCTGGATAGGACAGTTGC	0.333													4	26					0	0	0	0	G	2706416	G	G	2706416	3	3	82	1	0	0	0	0	1	0	0	0	14852	411	15	5	2069	5	SMCHD1	18	2706416	Missense_Mutation	SNP	A	TCGA-CN-6988-01A-11D-1912-08		2706416	75370832	149	16419											
SMCHD1	23347	broad.mit.edu	37	chr18	2738442	2738442	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaacacttgctacagggtctGcttcctgatgtgcaagtacc	9	11	10	11	0	1	1	0	1	1	0	2	2	2	1	2	1	6	4	2	1	4	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr18:2738442G>T	uc002klm.3	+	26	3513	c.3324G>T	c.(3322-3324)CTG>CTT	p.L1108L	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1108					chromosome organization		ATP binding				0						TACAGGGTCTGCTTCCTGATG	0.373													34	10					8.16721e-17	3.57826e-16	1	0	T	2738442	T	T	2738442	2	4	82	1	0	0	0	0	0	0	0	1	14852	1306	46	4		4	SMCHD1	18	2738442	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	32026	2738442	75338806	150	16420											
PSMA8	143471	broad.mit.edu	37	chr18	23772351	23772352	+	Frame_Shift_Ins	INS	-	A	A																															aaaaggaagaagcagagaagINSaaaaaatcaaagaaatctgt																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr18:23772351_23772352insA	uc002kvq.2	+	7	861_862	c.747_748insA	c.(745-750)AAGAAAfs	p.K249fs	PSMA8_uc002kvo.2_Frame_Shift_Ins_p.K205fs|PSMA8_uc002kvp.2_Frame_Shift_Ins_p.K243fs|PSMA8_uc002kvr.2_Frame_Shift_Ins_p.K217fs	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1	249_250					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)			AAGCAGAGAAGAAAAAATCAAA	0.302													---	---	---								A	23772352	A	A	23772351	7	5	82	1	0	1	1	0	0	0	0	0	12735	933	33	0	773	0	PSMA8	18	23772351	Frame_Shift_Ins	INS	-	TCGA-CN-6988-01A-11D-1912-08	21033909	23772351	54304897	151	16421											
TNFRSF11A	8792	broad.mit.edu	37	chr18	60025571	60025571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggacaaatgcagaccctggaCcaagtaagtaacaacaaagg	18	4	10	9	0	0	1	0	0	0	1	0	3	0	3	2	3	3	3	2	3	6	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr18:60025571C>T	uc002lin.2	+	5	556	c.518C>T	c.(517-519)ACC>ATC	p.T173I	TNFRSF11A_uc010dpv.2_Missense_Mutation_p.T173I	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	173	TNFR-Cys 4.|Extracellular (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity	p.T173A(1)		breast(2)|lung(1)	3		Colorectal(73;0.188)				AGACCCTGGACCAAGTAAGTA	0.478									Paget_Disease_of_Bone				21	52					0	0	0	0	T	60025571	T	T	60025571	3	4	82	1	0	0	0	0	1	0	0	0	16350	507	18	4	536	4	TNFRSF11A	18	60025571	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	36253220	60025571	18051677	152	16422											
ARRDC5	645432	broad.mit.edu	37	chr19	4903031	4903032	+	5'Flank	INS	-	TCACTGGTTCTTTT	TCACTGGTTCTTTT																															gattgggaaacctgtagtccINStcactggttctttttttttt																								rs144459964	by1000genomes	TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:4903031_4903032insTCACTGGTTCTTTT	uc002mbm.2	-							NM_001080523	NP_001073992	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5						signal transduction						0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		ACCTGTAGTCCTCACTGGttct	0.302													---	---	---								TCACTGGTTCTTTT	4903032	TCACTGGTTCTTTT	TCACTGGTTCTTTT	4903031	6	5	82	0	1	1	1	0	0	0	0	0	988	696	24	0		0	ARRDC5	19	4903031	5'Flank	INS	-	TCGA-CN-6988-01A-11D-1912-08		4903031	54225952	153	16423											
MUC16	94025	broad.mit.edu	37	chr19	9008172	9008172	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaccacatcacagccactcaCcattgacgtagagactgttc	13	8	6	14	1	2	2	2	1	0	1	3	3	2	2	3	0	2	2	3	0	2	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:9008172C>A	uc002mkp.2	-	41	39583	c.39379_splice	c.e41+1	p.G13127_splice	MUC16_uc010dwi.2_5'Flank|MUC16_uc010dwj.2_5'Flank|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16						cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGCCACTCACCATTGACGTA	0.527													57	158					1.87469e-40	9.00108e-40	1	0	A	9008172	A	A	9008172	5	1	82	1	0	0	0	0	0	0	1	0	10026	521	18	4	4319	4	MUC16	19	9008172	Splice_Site	SNP	C	TCGA-CN-6988-01A-11D-1912-08	4105141	9008172	50120811	154	16424											
RYR1	6261	broad.mit.edu	37	chr19	38979900	38979900	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcactgaggaagaagaggaGgaggacgaggaggaagaggg	15	3	20	3	1	1	4	1	1	0	3	1	11	1	10	0	7	0	0	0	7	3	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:38979900G>T	uc002oit.2	+	35	5761	c.5631G>T	c.(5629-5631)GAG>GAT	p.E1877D	RYR1_uc002oiu.2_Missense_Mutation_p.E1877D	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1877	Glu-rich (acidic).|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	aagaagaggaggaggacgagg	0.199													7	20					2.0095e-06	7.78264e-06	1	0	T	38979900	T	T	38979900	3	4	82	1	0	0	0	0	1	0	0	0	13833	991	35	4	5769	4	RYR1	19	38979900	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	29971728	38979900	20149083	155	16425											
EID2B	126272	broad.mit.edu	37	chr19	40023356	40023356	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actgccccccgcagtacgtcGctgacgccactcgcggtgcc	5	6	11	19	6	0	1	0	1	0	0	2	1	0	1	5	1	3	3	5	1	1	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:40023356G>A	uc002olz.1	-	1	139	c.87C>T	c.(85-87)AGC>AGT	p.S29S		NM_152361	NP_689574	Q96D98	EID2B_HUMAN	EP300 interacting inhibitor of differentiation	29					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCAGTACGTCGCTGACGCCAC	0.706											OREG0025463	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	8					0	0	0	0	A	40023356	A	A	40023356	2	1	82	1	0	0	0	0	0	0	0	1	5010	1078	38	1		1	EID2B	19	40023356	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	1043456	40023356	19105627	156	16426											
ATP1A3	478	broad.mit.edu	37	chr19	42492178	42492179	+	Frame_Shift_Ins	INS	-	C	C																															tccacagcaggatggagaagINScccccgaagagctgccggca																										TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:42492178_42492179insC	uc002osg.2	-	4	420_421	c.266_267insG	c.(265-267)GGCfs	p.G89fs	ATP1A3_uc010xwf.1_Frame_Shift_Ins_p.G100fs|ATP1A3_uc010xwg.1_Frame_Shift_Ins_p.G59fs|ATP1A3_uc010xwh.1_Frame_Shift_Ins_p.G102fs|ATP1A3_uc002osh.2_Frame_Shift_Ins_p.G89fs	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	89	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						GGATGGAGAAGCCCCCGAAGAG	0.639													---	---	---								C	42492179	C	C	42492178	7	5	82	1	0	1	1	0	0	0	0	0	1132	958	34	0	2854	0	ATP1A3	19	42492178	Frame_Shift_Ins	INS	-	TCGA-CN-6988-01A-11D-1912-08	2468822	42492178	16636805	157	16427											
GRIK5	2901	broad.mit.edu	37	chr19	42569484	42569484	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgatctgctcccgggccaaGgccaaggccagacgctcacc	8	6	11	16	2	2	2	1	1	1	1	3	2	3	2	5	3	1	2	5	3	2	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:42569484G>A	uc002osj.1	-	2	170	c.135C>T	c.(133-135)GCC>GCT	p.A45A	GRIK5_uc010eib.1_5'UTR	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	45	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CCCGGGCCAAGGCCAAGGCCA	0.567													14	34					0	0	0	0	A	42569484	A	A	42569484	2	1	82	1	0	0	0	0	0	0	0	1	6816	987	35	4		4	GRIK5	19	42569484	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	77306	42569484	16559499	158	16428											
LILRB5	10990	broad.mit.edu	37	chr19	54758761	54758761	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tactttgactttagacacagCgggggatgggctgccccctc	7	10	12	12	1	0	2	0	1	0	1	1	3	0	3	2	3	3	1	2	3	2	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:54758761C>G	uc002qex.2	-	6	1203	c.1092G>C	c.(1090-1092)CCG>CCC	p.P364P	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Silent_p.P355P|LILRB5_uc002qey.2_Silent_p.P364P|LILRB5_uc002qez.2_Silent_p.P264P|LILRB5_uc002qfa.1_Silent_p.P254P|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	364	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTAGACACAGCGGGGGATGGG	0.547													36	21					0	0	0	0	G	54758761	G	G	54758761	2	3	82	1	0	0	0	0	0	0	0	1	8835	755	27	3		3	LILRB5	19	54758761	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	12189277	54758761	4370222	159	16429											
ZNF582	147948	broad.mit.edu	37	chr19	56901764	56901764	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccagtgagaccaggttgctgTaggtctccaacatcacgtct	9	10	10	12	1	3	1	1	1	2	1	4	2	3	1	3	2	2	3	3	2	2	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:56901764T>C	uc002qmz.1	-	3	275	c.116A>G	c.(115-117)TAC>TGC	p.Y39C	ZNF582_uc002qmy.2_Missense_Mutation_p.Y70C	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		CAGGTTGCTGTAGGTCTCCAA	0.493													42	74					0	0	0	0	C	56901764	C	C	56901764	3	2	82	1	0	0	0	0	1	0	0	0	18081	1638	57	5	1449	5	ZNF582	19	56901764	Missense_Mutation	SNP	T	TCGA-CN-6988-01A-11D-1912-08	2143003	56901764	2227219	160	16430											
ZNF667	63934	broad.mit.edu	37	chr19	56953438	56953438	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaaggccttcgcattttcaGggattttctctccagcatga	8	15	8	10	1	2	1	1	1	1	0	5	2	3	2	2	2	1	2	2	2	1	6			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:56953438G>T	uc002qnd.2	-	5	1088	c.926C>A	c.(925-927)CCT>CAT	p.P309H	ZNF667_uc010etl.2_Missense_Mutation_p.P91H|ZNF667_uc002qne.2_Missense_Mutation_p.P309H|ZNF667_uc010etm.2_Missense_Mutation_p.P252H	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CGCATTTTCAGGGATTTTCTC	0.328													26	77					6.07407e-21	2.76489e-20	1	0	T	56953438	T	T	56953438	3	4	82	1	0	0	0	0	1	0	0	0	18141	1000	35	4	910	4	ZNF667	19	56953438	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	51674	56953438	2175545	161	16431											
PEG3	5178	broad.mit.edu	37	chr19	57335898	57335898	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacctctgatgaaaaaactcAgagtcagttggaccttctcc	13	10	7	11	0	4	3	2	2	2	1	5	4	4	4	3	1	2	1	3	1	4	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:57335898A>T	uc002qnu.2	-	1	477	c.126T>A	c.(124-126)TCT>TCA	p.S42S	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.S42S|PEG3_uc002qnv.2_Silent_p.S42S|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Silent_p.S42S	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	42					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GAAAAAACTCAGAGTCAGTTG	0.483													17	58					0	0	0	0	T	57335898	T	T	57335898	2	4	82	1	0	0	0	0	0	0	0	1	11774	175	7	5		5	PEG3	19	57335898	Silent	SNP	A	TCGA-CN-6988-01A-11D-1912-08	382460	57335898	1793085	162	16432											
AURKC	6795	broad.mit.edu	37	chr19	57746416	57746416	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccacagtgagacttacagacGcatcctcaaggtgggacagt	12	7	11	11	1	1	2	1	1	0	2	2	4	2	3	2	2	1	1	2	2	2	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:57746416G>T	uc002qoe.2	+	6	938	c.749G>T	c.(748-750)CGC>CTC	p.R250L	AURKC_uc002qoc.2_Missense_Mutation_p.R231L|AURKC_uc002qod.2_Missense_Mutation_p.R216L|AURKC_uc010etv.2_Missense_Mutation_p.R247L	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	250	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		ACTTACAGACGCATCCTCAAG	0.552													11	48					4.68919e-08	1.87836e-07	1	0	T	57746416	T	T	57746416	3	4	82	1	0	0	0	0	1	0	0	0	1226	1087	38	3	776	3	AURKC	19	57746416	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	410518	57746416	1382567	163	16433											
ZNF418	147686	broad.mit.edu	37	chr19	58437946	58437946	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccacattcataaggcctttCtccagtatgaactctccgat	10	13	5	13	1	3	1	1	1	2	0	6	2	4	1	4	1	1	1	4	1	3	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr19:58437946C>T	uc002qqs.1	-	4	1895	c.1603G>A	c.(1603-1605)GAA>AAA	p.E535K	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.E450K	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TAAGGCCTTTCTCCAGTATGA	0.448													15	51					0	0	0	0	T	58437946	T	T	58437946	3	4	82	1	0	0	0	0	1	0	0	0	17962	922	32	2	431	2	ZNF418	19	58437946	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	691530	58437946	691037	164	16434											
C20orf196	149840	broad.mit.edu	37	chr20	5753649	5753649	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcgaggctttcagttctttGgaattccattcttttcctta	7	18	7	9	1	3	0	1	0	2	0	5	2	5	1	2	2	1	2	2	2	2	8			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr20:5753649G>A	uc002wmf.2	+	2	225	c.138G>A	c.(136-138)TTG>TTA	p.L46L		NM_152504	NP_689717	Q8IYI0	CT196_HUMAN	hypothetical protein LOC149840	46											0						TCAGTTCTTTGGAATTCCATT	0.443													28	121					0	0	0	0	A	5753649	A	A	5753649	2	1	82	1	0	0	0	0	0	0	0	1	2111	1339	47	4		4	C20orf196	20	5753649	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08		5753649	57271871	165	16435											
CSTL1	128817	broad.mit.edu	37	chr20	23420933	23420933	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggatgctggagaaacccccTgctgctgctgattgccctgg	6	9	13	13	1	0	2	0	1	0	1	0	4	0	3	3	3	6	4	3	3	1	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr20:23420933T>C	uc002wte.2	+	2	275	c.29T>C	c.(28-30)CTG>CCG	p.L10P	CSTL1_uc010zsu.1_RNA|CSTL1_uc010zsv.1_RNA	NM_138283	NP_612140	Q9H114	CST1L_HUMAN	cystatin-like 1 precursor	10						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0993)|Lung NSC(19;0.235)					AGAAACCCCCTGCTGCTGCTG	0.552													18	51					0	0	0	0	C	23420933	C	C	23420933	3	2	82	1	0	0	0	0	1	0	0	0	4004	1580	55	5	31	5	CSTL1	20	23420933	Missense_Mutation	SNP	T	TCGA-CN-6988-01A-11D-1912-08	17667284	23420933	39604587	166	16436											
TOX2	84969	broad.mit.edu	37	chr20	42694723	42694723	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaggtgcagctggcgatGagcccctcacctccagggcc	6	6	12	17	1	1	1	1	1	0	0	3	2	3	1	6	3	3	2	6	3	0	0			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr20:42694723G>T	uc002xlf.3	+	6	1295	c.1278G>T	c.(1276-1278)ATG>ATT	p.M426I	TOX2_uc010ggo.2_Missense_Mutation_p.M444I|TOX2_uc002xle.3_Missense_Mutation_p.M402I|TOX2_uc010ggp.2_Missense_Mutation_p.M402I|TOX2_uc002xlg.2_Intron|TOX2_uc010zwk.1_Missense_Mutation_p.M322I	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	426	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AGCTGGCGATGAGCCCCTCAC	0.632													5	19					0.000602214	0.0022575	1	0	T	42694723	T	T	42694723	3	4	82	1	0	0	0	0	1	0	0	0	16445	1290	45	2	1488	2	TOX2	20	42694723	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	19273790	42694723	20330797	167	16437											
NCAM2	4685	broad.mit.edu	37	chr21	22838935	22838935	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttttcttctagcaatggttGttttgaacaacctggaacca	10	16	7	8	0	2	1	0	1	2	0	2	2	2	2	2	2	4	3	2	2	5	7			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr21:22838935G>T	uc002yld.1	+	13	1912	c.1663G>T	c.(1663-1665)GTT>TTT	p.V555F	NCAM2_uc011acb.1_Missense_Mutation_p.V413F	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	555	Fibronectin type-III 1.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		AGCAATGGTTGTTTTGAACAA	0.274													5	10					1.024e-07	4.07855e-07	1	0	T	22838935	T	T	22838935	3	4	82	1	0	0	0	0	1	0	0	0	10257	1377	48	4	1713	4	NCAM2	21	22838935	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08		22838935	25290960	168	16438											
KRTAP13-4	284827	broad.mit.edu	37	chr21	31803001	31803001	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agattctgctacccaaactaCttggcttctggagcctggca	9	11	9	12	0	2	1	0	0	2	1	2	2	2	2	2	3	5	3	2	3	3	5			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr21:31803001C>A	uc011acw.1	+	1	408	c.408C>A	c.(406-408)TAC>TAA	p.Y136*		NM_181600	NP_853631	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	136						intermediate filament					0						ACCCAAACTACTTGGCTTCTG	0.458													38	26					9.85521e-28	4.66791e-27	1	0	A	31803001	A	A	31803001	4	1	82	1	0	0	0	0	0	1	0	0	8564	576	20	4	410	4	KRTAP13-4	21	31803001	Nonsense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	8964066	31803001	16326894	169	16439											
DIP2A	23181	broad.mit.edu	37	chr21	47971570	47971570	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaccagcctcaatgatcGtggggaacctggttgctggg	7	10	15	9	1	1	1	1	1	0	0	2	3	1	3	3	5	3	2	3	5	2	2			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr21:47971570G>T	uc002zjo.2	+	24	3046	c.2863G>T	c.(2863-2865)GTG>TTG	p.V955L	DIP2A_uc011afy.1_Missense_Mutation_p.V891L|DIP2A_uc011afz.1_Missense_Mutation_p.V951L	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	955					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CTCAATGATCGTGGGGAACCT	0.507													14	13					1.05317e-09	4.34278e-09	1	0	T	47971570	T	T	47971570	3	4	82	1	0	0	0	0	1	0	0	0	4549	1145	40	3	3039	3	DIP2A	21	47971570	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	16168569	47971570	158325	170	16440											
CECR2	27443	broad.mit.edu	37	chr22	18028225	18028225	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaaaagctgctctgccccaGaggcagaacgttgcaggaaa	13	5	12	11	2	1	2	0	0	1	2	1	4	1	3	2	2	5	5	2	2	4	1			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr22:18028225G>C	uc010gqw.1	+	16	3308	c.3182G>C	c.(3181-3183)AGA>ACA	p.R1061T	CECR2_uc010gqv.1_Missense_Mutation_p.R919T|CECR2_uc002zml.2_Missense_Mutation_p.R920T|CECR2_uc002zmo.2_RNA	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	1103					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		CTCTGCCCCAGAGGCAGAACG	0.602													6	22					0	0	0	0	C	18028225	C	C	18028225	3	2	82	1	0	0	0	0	1	0	0	0	3221	942	33	2	3246	2	CECR2	22	18028225	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08		18028225	33276341	171	16441											
USP18	11274	broad.mit.edu	37	chr22	18650683	18650683	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agactgcaggccctgtatacGatccgggtgaaggactcctt	9	9	12	11	2	0	2	0	1	0	1	2	4	2	3	3	3	2	2	3	3	3	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chr22:18650683G>A	uc002zny.2	+	6	845	c.507G>A	c.(505-507)ACG>ACA	p.T169T		NM_017414	NP_059110	Q9UMW8	UBP18_HUMAN	ubiquitin specific protease 18	169					regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway|ubiquitin-dependent protein catabolic process	cytosol|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)	1						CCCTGTATACGATCCGGGTGA	0.547													35	37					0	0	0	0	A	18650683	A	A	18650683	2	1	82	1	0	0	0	0	0	0	0	1	17117	1045	37	1		1	USP18	22	18650683	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08	622458	18650683	32653883	172	16442											
FRMPD4	9758	broad.mit.edu	37	chrX	12736659	12736659	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccacacccgtggagtcgccGctctgcccctccctggggaa	5	6	12	18	3	1	0	0	0	1	0	3	2	2	2	6	3	1	1	6	3	1	0	rs148954983	byFrequency	TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chrX:12736659G>T	uc004cuz.1	+	16	4220	c.3714G>T	c.(3712-3714)CCG>CCT	p.P1238P	FRMPD4_uc011mij.1_Silent_p.P1230P	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1238					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TGGAGTCGCCGCTCTGCCCCT	0.602													40	12					3.09479e-21	1.42727e-20	1	0	T	12736659	T	T	12736659	2	4	82	1	0	0	0	0	0	0	0	1	6093	1074	38	3		3	FRMPD4	23	12736659	Silent	SNP	G	TCGA-CN-6988-01A-11D-1912-08		12736659	142533901	173	16443											
PAK3	5063	broad.mit.edu	37	chrX	110435821	110435821	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcatgagggaaaataagaacCctaatattgttaattattta	17	14	6	4	0	1	2	1	1	0	1	1	3	1	3	1	1	1	1	1	1	9	8			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chrX:110435821C>A	uc004epa.2	+	10	1039	c.1012C>A	c.(1012-1014)CCT>ACT	p.P338T	PAK3_uc010npt.1_Missense_Mutation_p.P323T|PAK3_uc010npu.1_Missense_Mutation_p.P323T|PAK3_uc004eoy.1_Missense_Mutation_p.P78T|PAK3_uc004eoz.2_Missense_Mutation_p.P323T|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.P359T|PAK3_uc010npw.1_Missense_Mutation_p.P344T	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	338	Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						AAATAAGAACCCTAATATTGT	0.313										TSP Lung(19;0.15)			6	6					0.00116845	0.00431095	1	0	A	110435821	A	A	110435821	3	1	82	1	0	0	0	0	1	0	0	0	11456	623	22	4	1117	4	PAK3	23	110435821	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	97699162	110435821	44834739	174	16444											
IGSF1	3547	broad.mit.edu	37	chrX	130409178	130409178	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aatgttgagtctggcagttcCccttgacactgaagagtcat	10	12	10	9	0	2	4	1	3	1	1	3	4	3	4	2	1	0	3	2	1	2	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chrX:130409178C>G	uc004ewd.2	-	17	3505	c.3267G>C	c.(3265-3267)GGG>GGC	p.G1089G	IGSF1_uc004ewe.3_Silent_p.G1083G|IGSF1_uc004ewf.2_Silent_p.G1069G	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1089	Extracellular (Potential).|Ig-like C2-type 11.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CTGGCAGTTCCCCTTGACACT	0.547													102	13					0	0	0	0	G	130409178	G	G	130409178	2	3	82	1	0	0	0	0	0	0	0	1	7635	610	22	4		4	IGSF1	23	130409178	Silent	SNP	C	TCGA-CN-6988-01A-11D-1912-08	19973357	130409178	24861382	175	16445											
USP26	83844	broad.mit.edu	37	chrX	132161248	132161248	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acatggtaagagcattaaggGgaattttaccccatgggaaa	15	9	11	6	0	0	1	0	0	0	1	0	3	0	3	2	4	2	2	2	4	5	4			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chrX:132161248G>T	uc010nrm.1	-	6	1471	c.1001C>A	c.(1000-1002)CCC>CAC	p.P334H	USP26_uc011mvf.1_Missense_Mutation_p.P334H	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	334					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					AGCATTAAGGGGAATTTTACC	0.368													29	4					6.07407e-21	2.76489e-20	1	0	T	132161248	T	T	132161248	3	4	82	1	0	0	0	0	1	0	0	0	17125	1232	43	4	1743	4	USP26	23	132161248	Missense_Mutation	SNP	G	TCGA-CN-6988-01A-11D-1912-08	1752070	132161248	23109312	176	16446											
AFF2	2334	broad.mit.edu	37	chrX	148048568	148048568	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgccccttctatccagcagCagcactaatgtccggagacc	9	8	8	16	1	1	1	0	0	1	1	3	2	3	1	5	1	4	3	5	1	2	3			TCGA-CN-6988-01A-11D-1912-08	TCGA-CN-6988-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	230b06a8-5f6e-41db-bb59-19e4e6c9afaf	cc2f24ac-fce9-4b5a-bff2-7f2f9595a426	g.chrX:148048568C>A	uc004fcp.2	+	14	3641	c.3162C>A	c.(3160-3162)AGC>AGA	p.S1054R	AFF2_uc004fcq.2_Missense_Mutation_p.S1044R|AFF2_uc004fcr.2_Missense_Mutation_p.S1015R|AFF2_uc011mxb.1_Missense_Mutation_p.S1019R|AFF2_uc004fcs.2_Missense_Mutation_p.S1019R|AFF2_uc011mxc.1_Missense_Mutation_p.S695R	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1054					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TATCCAGCAGCAGCACTAATG	0.448													132	21					7.55469e-51	3.6523e-50	1	0	A	148048568	A	A	148048568	3	1	82	1	0	0	0	0	1	0	0	0	357	709	25	4	3271	4	AFF2	23	148048568	Missense_Mutation	SNP	C	TCGA-CN-6988-01A-11D-1912-08	15887320	148048568	7221992	177	16447											
ACTRT2	140625	broad.mit.edu	37	chr1	2939015	2939015	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcatcagcctcggggacccGctgcaccaggcgcccgaggc	7	4	13	17	4	2	0	2	0	0	0	3	2	2	1	4	4	2	2	4	4	0	0	rs145991951		TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:2939015G>A	uc001ajz.2	+	1	970	c.765G>A	c.(763-765)CCG>CCA	p.P255P		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	255						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		TCGGGGACCCGCTGCACCAGG	0.657													11	62					0	0	0	0	A	2939015	A	A	2939015	2	1	83	1	0	0	0	0	0	0	0	1	219	1074	38	1		1	ACTRT2	1	2939015	Silent	SNP	G	TCGA-CN-6989-01A-11D-1912-08		2939015	246311606	1	16448											
STX12	23673	broad.mit.edu	37	chr1	28144385	28144385	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacattttggatgtcaatcaGatatttaaagatttggccat	13	15	8	5	0	2	2	2	0	0	2	2	4	2	3	1	2	0	0	1	2	4	6			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:28144385G>A	uc001bou.3	+	7	725	c.600G>A	c.(598-600)CAG>CAA	p.Q200Q		NM_177424	NP_803173	Q86Y82	STX12_HUMAN	syntaxin 12	200	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				cholesterol efflux|intracellular protein transport|protein stabilization|vesicle-mediated transport	Golgi apparatus|integral to membrane|membrane raft|phagocytic vesicle	SNAP receptor activity			breast(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|all_lung(284;9.43e-05)|Lung NSC(340;0.000185)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;3.96e-24)|Colorectal(126;3.46e-08)|COAD - Colon adenocarcinoma(152;1.83e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00258)|KIRC - Kidney renal clear cell carcinoma(1967;0.00302)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0649)		ATGTCAATCAGATATTTAAAG	0.333													6	27					0	0	0	0	A	28144385	A	A	28144385	2	1	83	1	0	0	0	0	0	0	0	1	15404	933	33	2		2	STX12	1	28144385	Silent	SNP	G	TCGA-CN-6989-01A-11D-1912-08	25205370	28144385	221106236	2	16449											
C8A	731	broad.mit.edu	37	chr1	57340684	57340684	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatctgcagtggtgacatCtgggatcaagccagctgctc	9	9	11	12	0	3	1	1	1	2	0	4	2	3	2	2	2	4	3	2	2	1	0			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:57340684C>A	uc001cyo.2	+	3	366	c.234C>A	c.(232-234)ATC>ATA	p.I78I		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	78	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GTGGTGACATCTGGGATCAAG	0.488													16	28					1.15088e-07	1.47725e-07	1	0	A	57340684	A	A	57340684	2	1	83	1	0	0	0	0	0	0	0	1	2427	903	32	2		2	C8A	1	57340684	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	29196299	57340684	191909937	3	16450											
ZZZ3	26009	broad.mit.edu	37	chr1	78098454	78098454	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacagccaaatagcctgtgaTttcttcaactactgcagaat	13	11	7	10	0	2	2	1	1	1	1	2	3	2	2	2	0	5	1	2	0	5	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:78098454T>C	uc001dhq.2	-	5	1062	c.586A>G	c.(586-588)ATC>GTC	p.I196V	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.I196V|ZZZ3_uc001dhp.2_Missense_Mutation_p.I196V	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						TAGCCTGTGATTTCTTCAACT	0.398													9	94					0	0	0	0	C	78098454	C	C	78098454	3	2	83	1	0	0	0	0	1	0	0	0	18323	1493	52	5	2169	5	ZZZ3	1	78098454	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	20757770	78098454	171152167	4	16451											
NOTCH2	4853	broad.mit.edu	37	chr1	120512221	120512221	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggaggcgaaggcacaatCatcaatgttctcactgcagt	13	8	10	10	1	3	0	3	0	1	0	4	2	3	1	0	3	1	3	0	3	3	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:120512221C>A	uc001eik.2	-	6	1277	c.1021G>T	c.(1021-1023)GAT>TAT	p.D341Y	NOTCH2_uc001eil.2_Missense_Mutation_p.D341Y|NOTCH2_uc001eim.3_Missense_Mutation_p.D258Y	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	341	Extracellular (Potential).|EGF-like 9; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGGCACAATCATCAATGTTC	0.562			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				14	57					6.31663e-08	8.23076e-08	1	0	A	120512221	A	A	120512221	3	1	83	1	0	0	0	0	1	0	0	0	10602	826	29	2	6510	2	NOTCH2	1	120512221	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	42413767	120512221	128738400	5	16452											
FLG	2312	broad.mit.edu	37	chr1	152282297	152282297	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgagtctgtggagctgtctgCtgactgctggtggcgggatc	4	12	17	8	1	2	2	0	2	2	0	3	4	2	4	0	4	3	3	0	4	0	0	rs139417173	by1000genomes	TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:152282297C>G	uc001ezu.1	-	3	5101	c.5065G>C	c.(5065-5067)GCA>CCA	p.A1689P		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1689	Ser-rich.|Filaggrin 10.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCTGTCTGCTGACTGCTGG	0.572									Ichthyosis				156	410					0	0	0	0	G	152282297	G	G	152282297	3	3	83	1	0	0	0	0	1	0	0	0	5954	797	28	4	7124	4	FLG	1	152282297	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	31770076	152282297	96968324	6	16453											
FLAD1	80308	broad.mit.edu	37	chr1	154961254	154961254	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gactgcccgtttgccccaggGatcgctggtcccctacatgc	5	9	11	16	2	0	0	0	0	0	0	2	2	1	1	5	2	4	2	5	2	1	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:154961254G>A	uc001fgf.1	+	2	1400	c.1046G>A	c.(1045-1047)GGA>GAA	p.G349E	FLAD1_uc001fgc.2_Missense_Mutation_p.G250E|FLAD1_uc001fgd.1_Missense_Mutation_p.G349E|FLAD1_uc001fge.1_Missense_Mutation_p.G252E|FLAD1_uc001fgg.1_Missense_Mutation_p.G252E|FLAD1_uc001fgh.1_Missense_Mutation_p.G82E	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	349					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTGCCCCAGGGATCGCTGGTC	0.562													16	83					0	0	0	0	A	154961254	A	A	154961254	3	1	83	1	0	0	0	0	1	0	0	0	5952	1174	41	2	1127	2	FLAD1	1	154961254	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	2678957	154961254	94289367	7	16454											
BAT2L2	23215	broad.mit.edu	37	chr1	171549100	171549100	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagctcctcacttcaaccatAtaggtaaatgctttaaaagt	14	12	5	10	0	2	0	2	0	0	0	3	0	3	0	2	1	3	3	2	1	7	6			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:171549100A>G	uc010pmg.1	+	28	7666	c.7400A>G	c.(7399-7401)TAT>TGT	p.Y2467C	BAT2L2_uc010pmh.1_Missense_Mutation_p.Y1379C|BAT2L2_uc010pmi.1_Missense_Mutation_p.Y304C|BAT2L2_uc010pmj.1_Translation_Start_Site	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	2467	Gln-rich.						protein C-terminus binding				0						CTTCAACCATATAGGTAAATG	0.448													4	25					0	0	0	0	G	171549100	G	G	171549100	3	3	83	1	0	0	0	0	1	0	0	0	1323	449	16	5	7506	5	BAT2L2	1	171549100	Missense_Mutation	SNP	A	TCGA-CN-6989-01A-11D-1912-08	16587846	171549100	77701521	8	16455											
NEK2	4751	broad.mit.edu	37	chr1	211843718	211843718	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctctgattttcccagcgaGttctttctggctaaaagctg	7	16	8	10	1	3	1	0	1	3	0	5	2	4	1	1	1	2	3	1	1	2	6			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:211843718G>C	uc001hir.1	-	5	816	c.670C>G	c.(670-672)CTC>GTC	p.L224V	NEK2_uc001hiq.1_Missense_Mutation_p.L224V|NEK2_uc001his.3_Missense_Mutation_p.L224V|NEK2_uc001hit.1_RNA	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	224	Protein kinase.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		TTCCCAGCGAGTTCTTTCTGG	0.343													19	202					0	0	0	0	C	211843718	C	C	211843718	3	2	83	1	0	0	0	0	1	0	0	0	10378	1029	36	4	683	4	NEK2	1	211843718	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	40294618	211843718	37406903	9	16456											
URB2	9816	broad.mit.edu	37	chr1	229794895	229794895	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcaggagggcatttacCtcatcctggacctctgcatc	7	11	10	13	0	2	0	1	0	1	0	4	2	3	2	3	3	4	4	3	3	1	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr1:229794895C>T	uc001hts.1	+	10	4562	c.4426C>T	c.(4426-4428)CTC>TTC	p.L1476F	URB2_uc009xfd.1_Missense_Mutation_p.L1476F	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1476						nucleolus				central_nervous_system(2)|ovary(1)	3						GGGCATTTACCTCATCCTGGA	0.517													54	127					0	0	0	0	T	229794895	T	T	229794895	3	4	83	1	0	0	0	0	1	0	0	0	17093	681	24	4	4460	4	URB2	1	229794895	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	17951177	229794895	19455726	10	16457											
ABHD1	84696	broad.mit.edu	37	chr2	27352690	27352690	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtggcagcactgactctgtCtgcatgctgggattcctttg	5	13	13	10	0	2	1	0	1	2	0	3	2	3	2	1	3	3	4	1	3	0	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:27352690C>T	uc002rit.2	+	6	846	c.686C>T	c.(685-687)TCT>TTT	p.S229F	ABHD1_uc002riu.2_RNA|ABHD1_uc002riv.2_RNA	NM_032604	NP_115993	Q96SE0	ABHD1_HUMAN	abhydrolase domain-containing protein 1	229						integral to membrane	carboxylesterase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGACTCTGTCTGCATGCTGG	0.567													16	81					0	0	0	0	T	27352690	T	T	27352690	3	4	83	1	0	0	0	0	1	0	0	0	73	913	32	2	708	2	ABHD1	2	27352690	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08		27352690	215846683	11	16458											
THADA	63892	broad.mit.edu	37	chr2	43801884	43801884	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcgtaaaagactctcagtCaattccacaaagaaaggatc	18	8	6	9	1	2	2	2	0	1	2	6	3	3	3	1	1	0	1	1	1	6	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:43801884C>T	uc002rsw.3	-	11	1672	c.1320G>A	c.(1318-1320)TTG>TTA	p.L440L	THADA_uc002rsx.3_Silent_p.L440L|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Silent_p.L150L|THADA_uc002rta.2_Silent_p.L150L|THADA_uc002rtb.1_Silent_p.L440L|THADA_uc002rtc.3_Silent_p.L440L|THADA_uc002rtd.2_Silent_p.L440L	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	440							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GACTCTCAGTCAATTCCACAA	0.418													34	83					0	0	0	0	T	43801884	T	T	43801884	2	4	83	1	0	0	0	0	0	0	0	1	15906	825	29	2		2	THADA	2	43801884	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	16449194	43801884	199397489	12	16459											
RANBP2	5903	broad.mit.edu	37	chr2	109382140	109382140	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaagcaaggctccaaagagCggatttgagggaatgttcac	14	7	12	8	1	1	2	1	1	0	1	2	4	2	4	1	3	2	3	1	3	4	2	rs139290272	byFrequency	TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:109382140C>T	uc002tem.3	+	20	5271	c.5145C>T	c.(5143-5145)AGC>AGT	p.S1715S		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1715					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CTCCAAAGAGCGGATTTGAGG	0.428													25	130					0	0	0	0	T	109382140	T	T	109382140	2	4	83	1	0	0	0	0	0	0	0	1	13093	767	27	1		1	RANBP2	2	109382140	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	65580256	109382140	133817233	13	16460											
WDR33	55339	broad.mit.edu	37	chr2	128471233	128471233	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atctccgggcctgcggccttCccatgcccccggagggcctc	3	7	12	19	3	1	0	0	0	1	0	4	1	2	1	7	4	2	0	7	4	0	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:128471233C>T	uc002tpg.1	-	18	3415	c.3232G>A	c.(3232-3234)GAA>AAA	p.E1078K		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	1078					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CTGCGGCCTTCCCATGCCCCC	0.677													33	128					0	0	0	0	T	128471233	T	T	128471233	3	4	83	1	0	0	0	0	1	0	0	0	17355	864	30	2	798	2	WDR33	2	128471233	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	19089093	128471233	114728140	14	16461											
ZEB2	9839	broad.mit.edu	37	chr2	145147391	145147391	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcgcgcgcctcgcgctccGccgcttcccgctcctccgcc	0	8	9	24	9	1	0	0	0	1	0	7	0	5	0	7	0	0	3	7	0	0	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:145147391G>T	uc002tvu.2	-	10	3752	c.3272C>A	c.(3271-3273)GCG>GAG	p.A1091E	ZEB2_uc002tvv.2_Missense_Mutation_p.A1085E|ZEB2_uc010zbm.1_Missense_Mutation_p.A1062E|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	1091	Glu-rich (acidic).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTCGCGCTCCGCCGCTTCCCG	0.602													17	91					5.01169e-05	6.20152e-05	1	0	T	145147391	T	T	145147391	3	4	83	1	0	0	0	0	1	0	0	0	17691	1087	38	3	376	3	ZEB2	2	145147391	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	16676158	145147391	98051982	15	16462											
TTN	7273	broad.mit.edu	37	chr2	179669322	179669322	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggtactaccctccagtacCacaacgctttgtaacggctg	9	9	9	14	3	0	0	0	0	0	0	1	0	1	0	3	2	5	5	3	2	5	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:179669322C>T	uc002und.2	-	2	273	c.48G>A	c.(46-48)GTG>GTA	p.V16V	TTN_uc010zfg.1_Silent_p.V16V|TTN_uc010zfh.1_Silent_p.V16V|TTN_uc010zfi.1_Silent_p.V16V|TTN_uc010zfj.1_Silent_p.V16V|TTN_uc002unb.2_Silent_p.V16V			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	16							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCCAGTACCACAACGCTTT	0.438													14	59					0	0	0	0	T	179669322	T	T	179669322	2	4	83	1	0	0	0	0	0	0	0	1	16803	581	21	4		4	TTN	2	179669322	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	34521931	179669322	63530051	16	16463											
NRP2	8828	broad.mit.edu	37	chr2	206562314	206562314	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaaagatgctggctatatCacctctcccggttaccccca	9	10	6	16	1	2	1	1	0	1	1	4	1	3	1	5	2	2	3	5	2	4	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:206562314C>T	uc002vaw.2	+	2	911	c.120C>T	c.(118-120)ATC>ATT	p.I40I	NRP2_uc002vat.2_Silent_p.I40I|NRP2_uc002vau.2_Silent_p.I40I|NRP2_uc002vav.2_Silent_p.I40I|NRP2_uc002vax.2_Silent_p.I40I|NRP2_uc002vay.2_Silent_p.I40I|NRP2_uc010fud.2_Silent_p.I40I	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	40	Extracellular (Potential).|CUB 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CTGGCTATATCACCTCTCCCG	0.498													62	371					0	0	0	0	T	206562314	T	T	206562314	2	4	83	1	0	0	0	0	0	0	0	1	10715	816	29	2		2	NRP2	2	206562314	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	26892992	206562314	36637059	17	16464											
CUL3	8452	broad.mit.edu	37	chr2	225376090	225376090	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttctgtctttccatttttCaacatatgtactagcccaga	9	16	4	12	0	3	1	1	0	2	1	4	1	4	1	3	0	3	1	3	0	4	7			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:225376090C>T	uc002vny.2	-	6	1248	c.864G>A	c.(862-864)TTG>TTA	p.L288L	CUL3_uc010zls.1_Silent_p.L222L|CUL3_uc010fwy.1_Silent_p.L294L	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	288					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TTCCATTTTTCAACATATGTA	0.338													24	110					0	0	0	0	T	225376090	T	T	225376090	2	4	83	1	0	0	0	0	0	0	0	1	4073	825	29	2		2	CUL3	2	225376090	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	18813776	225376090	17823283	18	16465											
CUL3	8452	broad.mit.edu	37	chr2	225378279	225378279	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catttccaaaaaaggagcctCaaaatcttcttcatagactg	15	11	5	10	0	4	1	2	0	2	1	5	2	5	2	2	1	1	0	2	1	6	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr2:225378279C>G	uc002vny.2	-	5	1000	c.616G>C	c.(616-618)GAG>CAG	p.E206Q	CUL3_uc010zls.1_Missense_Mutation_p.E140Q|CUL3_uc010fwy.1_Missense_Mutation_p.E212Q	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	206					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		AAAGGAGCCTCAAAATCTTCT	0.308													5	24					0	0	0	0	G	225378279	G	G	225378279	3	3	83	1	0	0	0	0	1	0	0	0	4073	835	29	2	1738	2	CUL3	2	225378279	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	2189	225378279	17821094	19	16466											
CNTN6	27255	broad.mit.edu	37	chr3	1367528	1367528	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatgggaacagaaaatccaaAatacacacctctctatctat	18	9	4	10	0	2	1	0	0	2	1	4	2	3	2	2	1	2	0	2	1	9	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:1367528A>T	uc003boz.2	+	9	1243	c.976A>T	c.(976-978)AAT>TAT	p.N326Y	CNTN6_uc011asj.1_Missense_Mutation_p.N254Y|CNTN6_uc003bpa.2_Missense_Mutation_p.N326Y	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	326	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GAAAATCCAAAATACACACCT	0.403													11	40					0	0	0	0	T	1367528	T	T	1367528	3	4	83	1	0	0	0	0	1	0	0	0	3660	14	1	5	1006	5	CNTN6	3	1367528	Missense_Mutation	SNP	A	TCGA-CN-6989-01A-11D-1912-08		1367528	196654902	20	16467											
CCR3	1232	broad.mit.edu	37	chr3	46307687	46307687	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctctgtctctccatccacAgcagagccggaactctctat	9	10	7	15	1	3	1	0	0	3	1	7	2	5	2	3	1	4	2	3	1	2	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:46307687A>T	uc003cpg.1	+	4	1581	c.1038A>T	c.(1036-1038)ACA>ACT	p.T346T	CCR3_uc003cpi.1_Silent_p.T346T|CCR3_uc003cpj.1_Silent_p.T346T|CCR3_uc003cpk.1_Silent_p.T367T|CCR3_uc010hjb.1_Silent_p.T364T|CCR3_uc003cpl.1_Silent_p.T379T	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	346	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CTCCATCCACAGCAGAGCCGG	0.488													14	28					0	0	0	0	T	46307687	T	T	46307687	2	4	83	1	0	0	0	0	0	0	0	1	2957	175	7	5		5	CCR3	3	46307687	Silent	SNP	A	TCGA-CN-6989-01A-11D-1912-08	44940159	46307687	151714743	21	16468											
ATR	545	broad.mit.edu	37	chr3	142176524	142176524	+	Frame_Shift_Del	DEL	A	-	-																															gaaaaagaccctctgttcccAtaggacccattccattaacc																										TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:142176524delA	uc003eux.3	-	45	7699	c.7577delT	c.(7576-7578)ATGfs	p.M2526fs	ATR_uc003euy.1_Frame_Shift_Del_p.M412fs	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2526	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CTCTGTTCCCATAGGACCCAT	0.388								Other_conserved_DNA_damage_response_genes					---	---	---								-	142176524	-	-	142176524	7	5	83	1	0	1	0	1	0	0	0	0	1206	217	8	0	369	0	ATR	3	142176524	Frame_Shift_Del	DEL	A	TCGA-CN-6989-01A-11D-1912-08	95868837	142176524	55845906	22	16469											
TSC22D2	9819	broad.mit.edu	37	chr3	150128558	150128558	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gccgtgcctcggtcctgccgGggctgggcagccccagtccg	2	6	16	17	4	0	0	0	0	0	0	3	0	2	0	7	4	3	2	7	4	0	0			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:150128558G>A	uc003exv.2	+	1	1771	c.1421G>A	c.(1420-1422)GGG>GAG	p.G474E	TSC22D2_uc003exw.2_RNA|TSC22D2_uc003exx.2_Missense_Mutation_p.G474E	NM_014779	NP_055594	O75157	T22D2_HUMAN	TSC22 domain family, member 2	474							sequence-specific DNA binding transcription factor activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GGTCCTGCCGGGGCTGGGCAG	0.726													6	44					0	0	0	0	A	150128558	A	A	150128558	3	1	83	1	0	0	0	0	1	0	0	0	16675	1232	43	4	1423	4	TSC22D2	3	150128558	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	7952034	150128558	47893872	23	16470											
MED12L	116931	broad.mit.edu	37	chr3	151101967	151101967	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccctgggggatctgaagaGaacaagcgtgcatacatgaa	13	7	12	9	1	1	3	0	2	1	1	2	5	2	4	2	2	4	1	2	2	5	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:151101967G>T	uc003eyp.2	+	33	4820	c.4782G>T	c.(4780-4782)GAG>GAT	p.E1594D	MED12L_uc011bnz.1_Missense_Mutation_p.E1454D|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.E757D	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1594					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GATCTGAAGAGAACAAGCGTG	0.378													50	44					6.3237e-29	8.77158e-29	1	0	T	151101967	T	T	151101967	3	4	83	1	0	0	0	0	1	0	0	0	9482	933	33	2	4912	2	MED12L	3	151101967	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	973409	151101967	46920463	24	16471											
SMC4	10051	broad.mit.edu	37	chr3	160150162	160150162	+	Frame_Shift_Del	DEL	A	-	-																															atatgaagatcttcggaaacAaaggcttaatgaatttatgg																										TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:160150162delA	uc003fdh.2	+	22	3502	c.3389delA	c.(3388-3390)CAAfs	p.Q1130fs	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Frame_Shift_Del_p.Q1105fs|SMC4_uc003fdj.2_Frame_Shift_Del_p.Q1130fs|SMC4_uc010hwd.2_Frame_Shift_Del_p.Q1072fs|SMC4_uc003fdl.2_Frame_Shift_Del_p.Q833fs	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1130					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CTTCGGAAACAAAGGCTTAAT	0.348													---	---	---								-	160150162	-	-	160150162	7	5	83	1	0	1	0	1	0	0	0	0	14849	130	5	0	3471	0	SMC4	3	160150162	Frame_Shift_Del	DEL	A	TCGA-CN-6989-01A-11D-1912-08	9048195	160150162	37872268	25	16472											
SI	6476	broad.mit.edu	37	chr3	164737435	164737435	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attccccaagtattccagttCagatctcgcttaaatgctgt	10	14	6	11	1	2	1	1	0	1	1	5	1	4	1	3	0	1	4	3	0	4	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:164737435C>T	uc003fei.2	-	28	3440	c.3378G>A	c.(3376-3378)CTG>CTA	p.L1126L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1126	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TATTCCAGTTCAGATCTCGCT	0.433										HNSCC(35;0.089)			38	158					0	0	0	0	T	164737435	T	T	164737435	2	4	83	1	0	0	0	0	0	0	0	1	14362	813	29	2		2	SI	3	164737435	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	4587273	164737435	33284995	26	16473											
SI	6476	broad.mit.edu	37	chr3	164777770	164777770	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataattccagcgacttagttGgaatccaagattccaatatg	14	12	7	8	1	0	1	0	0	0	1	3	3	3	2	3	1	1	1	3	1	6	6			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:164777770G>T	uc003fei.2	-	10	1128	c.1066C>A	c.(1066-1068)CAA>AAA	p.Q356K		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	356	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CGACTTAGTTGGAATCCAAGA	0.363										HNSCC(35;0.089)			44	420					1.22674e-20	1.6746e-20	1	0	T	164777770	T	T	164777770	3	4	83	1	0	0	0	0	1	0	0	0	14362	1357	47	4	4573	4	SI	3	164777770	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	40335	164777770	33244660	27	16474											
NAALADL2	254827	broad.mit.edu	37	chr3	175184818	175184818	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cactgcacacagttataatgGacaagaatgggccagtagta	15	8	10	8	0	0	1	0	0	0	1	0	2	0	2	1	2	1	4	1	2	6	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:175184818G>A	uc003fit.2	+	8	1466	c.1379G>A	c.(1378-1380)GGA>GAA	p.G460E	NAALADL2_uc003fiu.1_Missense_Mutation_p.G453E|NAALADL2_uc010hwy.1_Missense_Mutation_p.G234E|NAALADL2_uc010hwz.1_Missense_Mutation_p.G54E	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	460	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		AGTTATAATGGACAAGAATGG	0.408													7	555					0	0	0	0	A	175184818	A	A	175184818	3	1	83	1	0	0	0	0	1	0	0	0	10183	1174	41	2	1409	2	NAALADL2	3	175184818	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	10407048	175184818	22837612	28	16475											
ZNF639	51193	broad.mit.edu	37	chr3	179051488	179051488	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggaaagtttctctaccaatAtgcttctgatagaacatgcc	13	12	7	9	0	2	2	0	1	2	1	3	3	2	3	2	1	4	2	2	1	6	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:179051488A>G	uc003fjq.1	+	6	1079	c.736A>G	c.(736-738)ATG>GTG	p.M246V	ZNF639_uc003fjr.1_Missense_Mutation_p.M246V	NM_016331	NP_057415	Q9UID6	ZN639_HUMAN	zinc finger protein 639	246	C2H2-type 2.				initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CTCTACCAATATGCTTCTGAT	0.368													46	124					0	0	0	0	G	179051488	G	G	179051488	3	3	83	1	0	0	0	0	1	0	0	0	18123	449	16	5	750	5	ZNF639	3	179051488	Missense_Mutation	SNP	A	TCGA-CN-6989-01A-11D-1912-08	3866670	179051488	18970942	29	16476											
MFN1	55669	broad.mit.edu	37	chr3	179082965	179082965	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcctaatattttcattctCaataatcgttgggatgcctc	11	15	6	9	1	2	0	2	0	1	0	5	1	2	1	2	1	2	1	2	1	5	7			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr3:179082965C>T	uc003fjs.2	+	7	831	c.705C>T	c.(703-705)CTC>CTT	p.L235L	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Silent_p.L263L|MFN1_uc010hxc.2_Silent_p.L88L	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	235	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TTTTCATTCTCAATAATCGTT	0.338													10	164					0	0	0	0	T	179082965	T	T	179082965	2	4	83	1	0	0	0	0	0	0	0	1	9576	813	29	2		2	MFN1	3	179082965	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	31477	179082965	18939465	30	16477											
UBA6	55236	broad.mit.edu	37	chr4	68499067	68499067	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaatgcatacttaccttaTggttaaaatatttttcaaac	15	15	3	8	0	1	0	1	0	0	0	1	0	1	0	1	1	4	2	1	1	8	7			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:68499067T>C	uc003hdg.3	-	23	2190	c.2138A>G	c.(2137-2139)CAT>CGT	p.H713R		NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	713					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						ACTTACCTTATGGTTAAAATA	0.303													21	58					0	0	0	0	C	68499067	C	C	68499067	3	2	83	1	0	0	0	0	1	0	0	0	16900	1464	51	5	1064	5	UBA6	4	68499067	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08		68499067	122655209	31	16478											
ODAM	54959	broad.mit.edu	37	chr4	71063726	71063726	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggactctcccagttctCtttatcagctctagaccagt	8	13	6	14	0	4	1	1	0	3	1	7	2	5	2	3	1	1	2	3	1	2	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:71063726C>A	uc003hfc.2	+	4	244	c.227C>A	c.(226-228)TCT>TAT	p.S76Y		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	76	Gln-rich.				biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						TCCCAGTTCTCTTTATCAGCT	0.478													52	141					2.48909e-17	3.37105e-17	1	0	A	71063726	A	A	71063726	3	1	83	1	0	0	0	0	1	0	0	0	10878	913	32	2	241	2	ODAM	4	71063726	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	2564659	71063726	120090550	32	16479											
GRID2	2895	broad.mit.edu	37	chr4	94411922	94411922	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tattacacgcattgaaagttCcatccagtaagtaaacaatg	16	11	6	8	1	0	1	0	1	0	0	2	1	2	1	2	0	2	4	2	0	7	6			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:94411922C>T	uc011cdt.1	+	12	2249	c.1991C>T	c.(1990-1992)TCC>TTC	p.S664F	GRID2_uc011cdu.1_Missense_Mutation_p.S569F	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	664	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATTGAAAGTTCCATCCAGTAA	0.393													13	45					0	0	0	0	T	94411922	T	T	94411922	3	4	83	1	0	0	0	0	1	0	0	0	6811	855	30	2	2037	2	GRID2	4	94411922	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	23348196	94411922	96742354	33	16480											
USP53	54532	broad.mit.edu	37	chr4	120177469	120177469	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagacatgtgtacctctaaAtcttgtatcactcaccagaa	13	11	6	11	0	4	2	2	0	2	2	4	2	4	2	2	0	1	3	2	0	5	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:120177469A>G	uc003ics.3	+	7	1507	c.441A>G	c.(439-441)AAA>AAG	p.K147K	USP53_uc003icr.3_Silent_p.K147K|USP53_uc003icu.3_5'UTR	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	147					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						GTACCTCTAAATCTTGTATCA	0.323													5	8					0	0	0	0	G	120177469	G	G	120177469	2	3	83	1	0	0	0	0	0	0	0	1	17152	98	4	5		5	USP53	4	120177469	Silent	SNP	A	TCGA-CN-6989-01A-11D-1912-08	25765547	120177469	70976807	34	16481											
ASB5	140458	broad.mit.edu	37	chr4	177143474	177143474	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtacttacattagctcctGcttccagcagagttctggca	9	12	9	11	0	1	1	0	0	1	1	3	1	3	1	2	2	5	6	2	2	3	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:177143474G>C	uc003iuq.1	-	3	390	c.374C>G	c.(373-375)GCA>GGA	p.A125G	ASB5_uc003iup.1_Missense_Mutation_p.A72G	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	125	ANK 2.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		ATTAGCTCCTGCTTCCAGCAG	0.418													6	48					0	0	0	0	C	177143474	C	C	177143474	3	2	83	1	0	0	0	0	1	0	0	0	1028	1319	46	4	635	4	ASB5	4	177143474	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	56966005	177143474	14010802	35	16482											
FAT1	2195	broad.mit.edu	37	chr4	187557927	187557927	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtctggcatttctttctcGgtctggcttttcccgctcag	2	16	9	14	3	5	0	1	0	4	0	7	0	6	0	2	3	0	3	2	3	0	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr4:187557927G>A	uc003izf.2	-	5	3972	c.3784C>T	c.(3784-3786)CGA>TGA	p.R1262*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1262	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTTCTTTCTCGGTCTGGCTTT	0.478										HNSCC(5;0.00058)			119	168					0	0	0	0	A	187557927	A	A	187557927	4	1	83	1	0	0	0	0	0	1	0	0	5721	1124	39	1	10074	1	FAT1	4	187557927	Nonsense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	10414453	187557927	3596349	36	16483											
SEMA5A	9037	broad.mit.edu	37	chr5	9054270	9054270	+	Frame_Shift_Del	DEL	G	-	-																															agatgtcccctccataggccGgggctggattggagcaagag																										TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:9054270delG	uc003jek.2	-	19	3330	c.2618delC	c.(2617-2619)CCGfs	p.P873fs		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	873	TSP type-1 6.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TCCATAGGCCGGGGCTGGATT	0.607													---	---	---								-	9054270	-	-	9054270	7	5	83	1	0	1	0	1	0	0	0	0	14102	1116	39	0	626	0	SEMA5A	5	9054270	Frame_Shift_Del	DEL	G	TCGA-CN-6989-01A-11D-1912-08		9054270	171860990	37	16484											
MRPS30	10884	broad.mit.edu	37	chr5	44813292	44813292	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaagggaaaggcttttgaGacaaaactgtgctgatcaga	16	8	12	5	0	1	4	1	2	0	3	1	6	1	5	0	2	2	2	0	2	5	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:44813292G>A	uc003joh.2	+	4	976	c.938G>A	c.(937-939)AGA>AAA	p.R313K		NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	313					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					AGGCTTTTGAGACAAAACTGT	0.393													4	42					0	0	0	0	A	44813292	A	A	44813292	3	1	83	1	0	0	0	0	1	0	0	0	9893	942	33	2	952	2	MRPS30	5	44813292	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	35759022	44813292	136101968	38	16485											
RPS23	6228	broad.mit.edu	37	chr5	81571952	81571953	+	Missense_Mutation	DNP	GC	AT	AT																															gatcttggtctttccttcttGcctttgtatagggccaaaag																										TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:81571952_81571953GC>AT	uc003khu.2	-	4	500_501	c.407_408GC>AT	c.(406-408)GGC>GAT	p.G136D		NM_001025	NP_001016	P62266	RS23_HUMAN	ribosomal protein S23	136					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome				0		Lung NSC(167;0.0025)|all_lung(232;0.00278)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-42)|Epithelial(54;8.38e-37)|all cancers(79;1.42e-31)		TTTCCTTCTTGCCTTTGTATAG	0.381													8	67					0	0	0	0	AT	81571953	AT	AT	81571952	3	1	83	1	0	0	0	0	1	0	0	0	13699	1306	46	4	27	4	RPS23	5	81571952	Missense_Mutation	DNP	GC	TCGA-CN-6989-01A-11D-1912-08	36758660	81571952	99343308	39	16486											
PCDHA13	56136	broad.mit.edu	37	chr5	140263131	140263131	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctatgaactggtggtgacCgcgcgggacgggggctcgcc	5	6	18	12	5	0	2	0	2	0	0	1	3	0	3	3	5	1	1	3	5	2	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:140263131C>T	uc003lif.2	+	1	1278	c.1278C>T	c.(1276-1278)ACC>ACT	p.T426T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.T426T|PCDHA13_uc003lid.2_Silent_p.T426T	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	426	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGGTGACCGCGCGGGACG	0.657													34	157					0	0	0	0	T	140263131	T	T	140263131	2	4	83	1	0	0	0	0	0	0	0	1	11577	639	23	1		1	PCDHA13	5	140263131	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	58691179	140263131	40652129	40	16487											
TCERG1	10915	broad.mit.edu	37	chr5	145836812	145836812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgggtatgatgtttccaccaGgaatgcctcctgtgactgct	7	12	11	11	1	0	2	0	2	0	0	2	3	2	3	4	2	2	3	4	2	2	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:145836812G>A	uc003lob.2	+	3	392	c.352G>A	c.(352-354)GGA>AGA	p.G118R	TCERG1_uc003loc.2_Missense_Mutation_p.G118R|TCERG1_uc011dbt.1_Missense_Mutation_p.G118R	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	118	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTTCCACCAGGAATGCCTCC	0.453													18	81					0	0	0	0	A	145836812	A	A	145836812	3	1	83	1	0	0	0	0	1	0	0	0	15751	1001	35	4	362	4	TCERG1	5	145836812	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	5573681	145836812	35078448	41	16488											
ADAM19	8728	broad.mit.edu	37	chr5	156934146	156934146	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggtgccgtggaaggacatgCccctgcaggaggcaaggaga	10	5	17	9	1	0	1	0	0	0	1	0	5	0	4	3	6	3	2	3	6	2	0			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:156934146C>T	uc003lwz.2	-	10	972	c.908G>A	c.(907-909)GGC>GAC	p.G303D	ADAM19_uc003lww.1_Missense_Mutation_p.G36D|ADAM19_uc011ddr.1_Missense_Mutation_p.G234D	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	303	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAAGGACATGCCCCTGCAGGA	0.622													4	75					0	0	0	0	T	156934146	T	T	156934146	3	4	83	1	0	0	0	0	1	0	0	0	240	739	26	4	1904	4	ADAM19	5	156934146	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	11097334	156934146	23981114	42	16489											
C5orf41	153222	broad.mit.edu	37	chr5	172517748	172517748	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctcctgtgtgttcttctaAgactctgcaggctgaggtcc	5	14	11	11	0	3	2	0	1	3	1	5	2	5	2	2	2	2	4	2	2	1	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:172517748A>G	uc003mch.2	+	4	870	c.566A>G	c.(565-567)AAG>AGG	p.K189R	C5orf41_uc003mcg.2_Missense_Mutation_p.K189R|C5orf41_uc003mcf.2_Missense_Mutation_p.K189R|C5orf41_uc011dfd.1_Missense_Mutation_p.K189R	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	189							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGTTCTTCTAAGACTCTGCAG	0.438													8	26					0	0	0	0	G	172517748	G	G	172517748	3	3	83	1	0	0	0	0	1	0	0	0	2310	72	3	5	576	5	C5orf41	5	172517748	Missense_Mutation	SNP	A	TCGA-CN-6989-01A-11D-1912-08	15583602	172517748	8397512	43	16490											
MAPK9	5601	broad.mit.edu	37	chr5	179669687	179669687	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataattcctcacagttggctGaagtttcttcatgaactctg	10	15	7	9	0	4	2	2	2	2	0	5	2	5	2	1	1	1	3	1	1	3	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr5:179669687G>T	uc003mls.3	-	8	1028	c.757C>A	c.(757-759)CAG>AAG	p.Q253K	MAPK9_uc003mlt.3_Missense_Mutation_p.Q253K|MAPK9_uc010jlc.2_Missense_Mutation_p.Q253K|MAPK9_uc003mlv.3_Missense_Mutation_p.Q253K	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	253	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAGTTGGCTGAAGTTTCTTC	0.388													5	46					1.23904e-05	1.54431e-05	1	0	T	179669687	T	T	179669687	3	4	83	1	0	0	0	0	1	0	0	0	9340	1299	45	2	542	2	MAPK9	5	179669687	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	7151939	179669687	1245573	44	16491											
DSP	1832	broad.mit.edu	37	chr6	7585963	7585963	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacaacatgtcttcggctcCggggtcccgctccggctccc	4	10	10	17	4	1	0	0	0	1	0	6	0	5	0	4	4	2	3	4	4	2	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr6:7585963C>T	uc003mxp.1	+	24	8747	c.8468C>T	c.(8467-8469)CCG>CTG	p.P2823L	DSP_uc003mxq.1_Missense_Mutation_p.P2224L	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2823	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TCTTCGGCTCCGGGGtcccgc	0.428													5	120					0	0	0	0	T	7585963	T	T	7585963	3	4	83	1	0	0	0	0	1	0	0	0	4803	652	23	1	8562	1	DSP	6	7585963	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08		7585963	163529104	45	16492											
EEF1E1	9521	broad.mit.edu	37	chr6	8102741	8102742	+	Missense_Mutation	DNP	GC	AA	AA																															tctccagtagcgacaactctGcggccgccgccatcttccgg																										TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr6:8102741_8102742GC>AA	uc003mxz.2	-	1	87_88	c.13_14GC>TT	c.(13-15)GCA>TTA	p.A5L	EEF1E1_uc011dic.1_Missense_Mutation_p.A5L	NM_004280	NP_004271	O43324	MCA3_HUMAN	eukaryotic translation elongation factor 1	5					negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of DNA damage response, signal transduction by p53 class mediator|tRNA aminoacylation for protein translation	cytosol|nucleus					0	Ovarian(93;0.0398)					CGACAACTCTGCGGCCGCCGCC	0.604													6	47					0	0	0	0	AA	8102742	AA	AA	8102741	3	1	83	1	0	0	0	0	1	0	0	0	4949	1319	46	4	566	4	EEF1E1	6	8102741	Missense_Mutation	DNP	GC	TCGA-CN-6989-01A-11D-1912-08	516778	8102741	163012326	46	16493											
HSP90AB1	3326	broad.mit.edu	37	chr6	44217786	44217786	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attggcaggggtaccaaagtGatcctccatcttaaagaaga	14	9	10	8	0	1	3	0	1	1	2	3	3	3	3	3	3	1	2	3	3	5	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr6:44217786G>A	uc003oxa.1	+	5	627	c.543G>A	c.(541-543)GTG>GTA	p.V181V	HSP90AB1_uc011dvr.1_Silent_p.V171V|HSP90AB1_uc003oxb.1_Silent_p.V181V|HSP90AB1_uc011dvs.1_Missense_Mutation_p.M1I|HSP90AB1_uc003oxc.1_5'UTR	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	181					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GTACCAAAGTGATCCTCCATC	0.438													23	78					0	0	0	0	A	44217786	A	A	44217786	2	1	83	1	0	0	0	0	0	0	0	1	7441	1277	45	2		2	HSP90AB1	6	44217786	Silent	SNP	G	TCGA-CN-6989-01A-11D-1912-08	36115045	44217786	126897281	47	16494											
CD2AP	23607	broad.mit.edu	37	chr6	47563619	47563619	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaaatcaacactggaacaGaaaccttctaaaccagcagc	19	5	6	11	0	2	1	1	0	1	1	2	3	2	2	2	1	6	1	2	1	7	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr6:47563619G>A	uc003oyw.2	+	12	1587	c.1131G>A	c.(1129-1131)CAG>CAA	p.Q377Q		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	377	Pro-rich.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			CACTGGAACAGAAACCTTCTA	0.353													25	190					0	0	0	0	A	47563619	A	A	47563619	2	1	83	1	0	0	0	0	0	0	0	1	3009	933	33	2		2	CD2AP	6	47563619	Silent	SNP	G	TCGA-CN-6989-01A-11D-1912-08	3345833	47563619	123551448	48	16495											
TFAP2B	7021	broad.mit.edu	37	chr6	50810853	50810853	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggcgcaggaccggacaccGatagggaacagccgacccag	11	2	14	14	4	0	0	0	0	0	0	0	5	0	3	4	4	2	1	4	4	2	1	rs140849621		TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr6:50810853G>A	uc003pag.2	+	7	1297	c.1131G>A	c.(1129-1131)CCG>CCA	p.P377P		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	377				QLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLIT HGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTS GEGPGSKTGDKEEKHRK -> GNFVKNLRIYWRRTGHR (in Ref. 1; CAA71047).	nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					ACCGGACACCGATAGGGAACA	0.592													60	142					0	0	0	0	A	50810853	A	A	50810853	2	1	83	1	0	0	0	0	0	0	0	1	15854	1045	37	1		1	TFAP2B	6	50810853	Silent	SNP	G	TCGA-CN-6989-01A-11D-1912-08	3247234	50810853	120304214	49	16496											
TBL2	26608	broad.mit.edu	37	chr7	72987687	72987687	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtcgatgacaggcgccttGtgctttttagggaagtcctc	7	13	12	9	2	0	1	0	1	0	0	3	3	1	2	2	2	1	1	2	2	2	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr7:72987687G>A	uc003tyh.2	-	4	695	c.561C>T	c.(559-561)CAC>CAT	p.H187H	TBL2_uc011kex.1_Silent_p.H151H|TBL2_uc010lbg.2_Silent_p.H92H|TBL2_uc003tyi.2_Silent_p.H22H|TBL2_uc011key.1_Silent_p.H58H|TBL2_uc010lbh.2_Silent_p.H92H	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	187	WD 3.										0		Lung NSC(55;0.0659)|all_lung(88;0.152)				CAGGCGCCTTGTGCTTTTTAG	0.557													28	134					0	0	0	0	A	72987687	A	A	72987687	2	1	83	1	0	0	0	0	0	0	0	1	15708	1368	48	4		4	TBL2	7	72987687	Silent	SNP	G	TCGA-CN-6989-01A-11D-1912-08		72987687	86150976	50	16497											
STEAP4	79689	broad.mit.edu	37	chr7	87913481	87913481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacactggagcattttcaatCccagtgatcttccaaaatca	13	11	5	12	0	3	1	2	1	1	0	5	2	5	2	2	1	1	1	2	1	3	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr7:87913481C>T	uc003ujs.2	-	2	209	c.104G>A	c.(103-105)GGA>GAA	p.G35E	STEAP4_uc010lek.2_Missense_Mutation_p.G35E|STEAP4_uc003ujt.2_Missense_Mutation_p.G35E	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	35					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					CATTTTCAATCCCAGTGATCT	0.413													10	100					0	0	0	0	T	87913481	T	T	87913481	3	4	83	1	0	0	0	0	1	0	0	0	15346	855	30	2	1291	2	STEAP4	7	87913481	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	14925794	87913481	71225182	51	16498											
SRRT	51593	broad.mit.edu	37	chr7	100484783	100484783	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgggatcatccacgttcGggggcccatgccacccaacc	7	7	11	16	2	1	0	1	0	0	0	3	1	2	1	5	3	2	1	5	3	1	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr7:100484783G>A	uc003uwy.2	+	16	2205	c.1937G>A	c.(1936-1938)CGG>CAG	p.R646Q	SRRT_uc010lhl.1_Missense_Mutation_p.R645Q|SRRT_uc003uxa.2_Missense_Mutation_p.R645Q|SRRT_uc003uwz.2_Missense_Mutation_p.R646Q	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	646					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						ATCCACGTTCGGGGGCCCATG	0.602													26	184					0	0	0	0	A	100484783	A	A	100484783	3	1	83	1	0	0	0	0	1	0	0	0	15238	1116	39	1	1991	1	SRRT	7	100484783	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	12571302	100484783	58653880	52	16499											
GPR37	2861	broad.mit.edu	37	chr7	124404598	124404598	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcctctgagatctgaaggaAgagctggagggccgtggggt	8	8	17	8	1	2	3	0	2	2	2	3	6	3	5	2	5	1	1	2	5	2	0			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr7:124404598A>T	uc003vli.2	-	1	1084	c.433T>A	c.(433-435)TTC>ATC	p.F145I		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	145	Extracellular (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						ATCTGAAGGAAGAGCTGGAGG	0.627													17	154					0	0	0	0	T	124404598	T	T	124404598	3	4	83	1	0	0	0	0	1	0	0	0	6729	72	3	5	1416	5	GPR37	7	124404598	Missense_Mutation	SNP	A	TCGA-CN-6989-01A-11D-1912-08	23919815	124404598	34734065	53	16500											
TRIM24	8805	broad.mit.edu	37	chr7	138239468	138239469	+	Missense_Mutation	DNP	GA	TT	TT																															ttagtaatcgaggataaagaGagccagccacaaatgcctaa																										TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr7:138239468_138239469GA>TT	uc003vuc.2	+	9	1502_1503	c.1287_1288GA>TT	c.(1285-1290)GAGAGC>GATTGC	p.429_430ES>DC	TRIM24_uc003vub.2_Missense_Mutation_p.429_430ES>DC	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	429_430					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						AGGATAAAGAGAGCCAGCCACA	0.371													10	113					0	0	0	0	TT	138239469	TT	TT	138239468	3	4	83	1	0	0	0	0	1	0	0	0	16565	933	33	2	1321	2	TRIM24	7	138239468	Missense_Mutation	DNP	GA	TCGA-CN-6989-01A-11D-1912-08	13834870	138239468	20899195	54	16501											
SORBS3	10174	broad.mit.edu	37	chr8	22429318	22429318	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcctctcctaacacctctCagatacactggaccccgtga	9	9	5	18	1	2	2	1	1	2	1	5	3	3	3	6	1	2	0	6	1	2	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr8:22429318C>T	uc003xbv.2	+	19	2171	c.1831C>T	c.(1831-1833)CAG>TAG	p.Q611*	SORBS3_uc003xbw.3_Nonsense_Mutation_p.Q269*	NM_005775	NP_005766	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3 isoform 1	611					muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding				0		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		TAACACCTCTCAGATACACTG	0.607													12	77					0	0	0	0	T	22429318	T	T	22429318	4	4	83	1	0	0	0	0	0	1	0	0	14993	827	29	2	1901	2	SORBS3	8	22429318	Nonsense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08		22429318	123934704	55	16502											
POTEA	340441	broad.mit.edu	37	chr8	43157231	43157231	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacaaactgctgaagattatGcagtttctagtcatcatagt	13	13	8	7	0	3	2	2	1	1	1	3	3	3	2	0	0	3	3	0	0	5	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr8:43157231G>C	uc003xpz.1	+	5	854	c.811G>C	c.(811-813)GCA>CCA	p.A271P	POTEA_uc003xqa.1_Intron	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	271										ovary(1)	1						TGAAGATTATGCAGTTTCTAG	0.294													14	52					0	0	0	0	C	43157231	C	C	43157231	3	2	83	1	0	0	0	0	1	0	0	0	12316	1319	46	4	829	4	POTEA	8	43157231	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	20727913	43157231	103206791	56	16503											
SNX16	64089	broad.mit.edu	37	chr8	82713776	82713776	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacttctgctacttctatctCtgatacagcattttcaggtt	8	17	5	11	0	4	1	1	1	3	0	5	1	4	1	0	1	4	3	0	1	3	8			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr8:82713776C>T	uc011lft.1	-	9	1498	c.991G>A	c.(991-993)GAG>AAG	p.E331K	SNX16_uc003ycn.2_Missense_Mutation_p.E331K|SNX16_uc003yco.2_Missense_Mutation_p.E302K	NM_022133	NP_071416	P57768	SNX16_HUMAN	sorting nexin 16 isoform a	331					cell communication|early endosome to late endosome transport|endosome to lysosome transport|protein targeting to lysosome	early endosome membrane|extrinsic to endosome membrane|late endosome membrane|lysosome	identical protein binding|phosphatidylinositol binding			ovary(1)|pancreas(1)	2						ACTTCTATCTCTGATACAGCA	0.353													5	107					0	0	0	0	T	82713776	T	T	82713776	3	4	83	1	0	0	0	0	1	0	0	0	14951	922	32	2	47	2	SNX16	8	82713776	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	39556545	82713776	63650246	57	16504											
KCNV1	27012	broad.mit.edu	37	chr8	110980374	110980374	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgctctttctctgcctttCagtcgcagcatctccatgat	5	16	6	14	1	4	1	1	1	3	0	7	1	4	1	2	0	3	3	2	0	0	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr8:110980374C>T	uc003ynr.3	-	3	1788	c.1446G>A	c.(1444-1446)CTG>CTA	p.L482L	KCNV1_uc010mcw.2_Silent_p.L482L	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	482	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CTCTGCCTTTCAGTCGCAGCA	0.388													10	35					0	0	0	0	T	110980374	T	T	110980374	2	4	83	1	0	0	0	0	0	0	0	1	8133	813	29	2		2	KCNV1	8	110980374	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	28266598	110980374	35383648	58	16505											
SPTLC1	10558	broad.mit.edu	37	chr9	94794749	94794749	+	Nonstop_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atggtcccgggactctgcctAgagcaggacggcctgggcta	7	7	15	12	2	1	1	0	0	1	1	2	3	2	3	3	5	2	2	3	5	2	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr9:94794749A>G	uc004arl.1	-	15	1458	c.1420T>C	c.(1420-1422)TAG>CAG	p.*474Q	SPTLC1_uc011ltv.1_Missense_Mutation_p.L463P	NM_006415	NP_006406	O15269	SPTC1_HUMAN	serine palmitoyltransferase subunit 1 isoform a	474						integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			ovary(1)|breast(1)	2					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GACTCTGCCTAGAGCAGGACG	0.582													11	45					0	0	0	0	G	94794749	G	G	94794749	4	3	83	1	0	0	0	0	0	0	0	0	15189	433	15	5	5	5	SPTLC1	9	94794749	Nonstop_Mutation	SNP	A	TCGA-CN-6989-01A-11D-1912-08		94794749	46418682	59	16506											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112898859	112898859	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccggcaggcacctcctcaCatcgagctcagtaatagcag	11	6	10	14	2	2	0	2	0	0	0	4	1	3	0	3	2	3	5	3	2	2	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr9:112898859C>T	uc004bei.2	+	9	1923	c.1731C>T	c.(1729-1731)CAC>CAT	p.H577H	PALM2-AKAP2_uc004bek.3_Silent_p.H345H|PALM2-AKAP2_uc004bej.3_Silent_p.H345H|PALM2-AKAP2_uc004bel.1_Silent_p.H155H|AKAP2_uc011lwi.1_Silent_p.H203H|AKAP2_uc004bem.2_Silent_p.H203H|PALM2-AKAP2_uc010mtw.1_Silent_p.H163H|AKAP2_uc011lwj.1_Silent_p.H114H|PALM2-AKAP2_uc004ben.2_Silent_p.H114H	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	114							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						CACCTCCTCACATCGAGCTCA	0.622													9	62					0	0	0	0	T	112898859	T	T	112898859	2	4	83	1	0	0	0	0	0	0	0	1	11464	477	17	4		4	PALM2-AKAP2	9	112898859	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	18104110	112898859	28314572	60	16507											
NOTCH1	4851	broad.mit.edu	37	chr9	139407980	139407980	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccacccagggtcacagtcGcacttgtacctgcaaggggg	8	7	12	14	1	1	0	1	0	0	0	3	0	2	0	3	3	2	3	3	3	2	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr9:139407980G>T	uc004chz.2	-	14	2217	c.2217C>A	c.(2215-2217)TGC>TGA	p.C739*	NOTCH1_uc004cia.1_5'UTR	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	739	Extracellular (Potential).|EGF-like 19; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGTCACAGTCGCACTTGTACC	0.612			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			16	9					3.41278e-10	4.55038e-10	1	0	T	139407980	T	T	139407980	4	4	83	1	0	0	0	0	0	1	0	0	10601	1079	38	3	5534	3	NOTCH1	9	139407980	Nonsense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	26509121	139407980	1805451	61	16508											
SLC39A12	221074	broad.mit.edu	37	chr10	18289628	18289628	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttgttagcaatcatgattCtggttggggacagcctgcat	8	13	12	8	0	2	1	1	1	1	0	2	2	2	2	1	3	3	5	1	3	2	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr10:18289628C>T	uc001ipo.2	+	11	1906	c.1633C>T	c.(1633-1635)CTG>TTG	p.L545L	SLC39A12_uc001ipn.2_Silent_p.L508L|SLC39A12_uc001ipp.2_Silent_p.L544L|SLC39A12_uc010qck.1_Silent_p.L411L	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	545	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						AATCATGATTCTGGTTGGGGA	0.423													21	58					0	0	0	0	T	18289628	T	T	18289628	2	4	83	1	0	0	0	0	0	0	0	1	14679	912	32	2		2	SLC39A12	10	18289628	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08		18289628	117245119	62	16509											
OR52K1	390036	broad.mit.edu	37	chr11	4510853	4510853	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcccgctacaaggcatttggGacatgtgtgtctcacatagg	9	10	12	10	1	1	0	1	0	1	0	2	1	1	1	1	3	1	2	1	3	3	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:4510853G>A	uc001lza.1	+	1	723	c.723G>A	c.(721-723)GGG>GGA	p.G241G		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		AGGCATTTGGGACATGTGTGT	0.537													55	121					0	0	0	0	A	4510853	A	A	4510853	2	1	83	1	0	0	0	0	0	0	0	1	11177	1161	41	2		2	OR52K1	11	4510853	Silent	SNP	G	TCGA-CN-6989-01A-11D-1912-08		4510853	130495663	63	16510											
FNBP4	23360	broad.mit.edu	37	chr11	47741494	47741494	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttttacctaaccagctgctGctgtttccactcttcaattc	7	16	4	14	0	2	0	1	0	1	0	4	0	3	0	3	0	5	4	3	0	3	6			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:47741494G>A	uc009ylv.2	-	16	3103	c.2950C>T	c.(2950-2952)CAG>TAG	p.Q984*	FNBP4_uc001ngi.2_Nonsense_Mutation_p.Q298*|FNBP4_uc001ngj.2_Nonsense_Mutation_p.Q891*	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	984										ovary(1)	1						ACCAGCTGCTGCTGTTTCCAC	0.443													12	60					0	0	0	0	A	47741494	A	A	47741494	4	1	83	1	0	0	0	0	0	1	0	0	5999	1328	46	4	111	4	FNBP4	11	47741494	Nonsense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	43230641	47741494	87265022	64	16511											
OR5T1	390155	broad.mit.edu	37	chr11	56043788	56043788	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgagatagtcactatcctgaTtgtcctgatctcctatggtt	8	16	8	9	0	2	3	1	3	1	1	5	4	4	3	3	1	0	1	3	1	3	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:56043788T>C	uc001nio.1	+	1	674	c.674T>C	c.(673-675)ATT>ACT	p.I225T		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	225	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					ACTATCCTGATTGTCCTGATC	0.428													58	131					0	0	0	0	C	56043788	C	C	56043788	3	2	83	1	0	0	0	0	1	0	0	0	11235	1493	52	5	676	5	OR5T1	11	56043788	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	8302294	56043788	78962728	65	16512											
CTTN	2017	broad.mit.edu	37	chr11	70275169	70275178	+	Frame_Shift_Del	DEL	CAAGTAACAT	-	-																															ctctatagtgaccagcaaaaCaagtaacatcagagctaact																										TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:70275169_70275178delCAAGTAACAT	uc001opv.3	+	14	1246_1255	c.1040_1049delCAAGTAACAT	c.(1039-1050)ACAAGTAACATCfs	p.T347fs	CTTN_uc001opu.2_Frame_Shift_Del_p.T310fs|CTTN_uc001opw.3_Frame_Shift_Del_p.T310fs|CTTN_uc010rqm.1_Frame_Shift_Del_p.T31fs|CTTN_uc001opx.2_Frame_Shift_Del_p.T31fs	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	347_350						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		ACCAGCAAAACAAGTAACATCAGAGCTAAC	0.567													---	---	---								-	70275178	-	-	70275169	7	5	83	1	0	1	0	1	0	0	0	0	4061	478	17	0	1086	0	CTTN	11	70275169	Frame_Shift_Del	DEL	CAAGTAACAT	TCGA-CN-6989-01A-11D-1912-08	14231381	70275169	64731347	66	16513											
SHANK2	22941	broad.mit.edu	37	chr11	70319378	70319378	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagggtctctttgttcatctCtgttggcgagaccacagggc	6	12	12	11	1	3	1	1	0	2	1	5	2	3	1	1	3	0	2	1	3	0	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:70319378C>G	uc001oqc.2	-	22	5224	c.5146G>C	c.(5146-5148)GAG>CAG	p.E1716Q	SHANK2_uc010rqn.1_Missense_Mutation_p.E1128Q|SHANK2_uc001opz.2_Missense_Mutation_p.E1121Q|uc009ysn.1_Intron|SHANK2_uc001opy.2_Missense_Mutation_p.E52Q	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1337					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTGTTCATCTCTGTTGGCGAG	0.632													26	420					0	0	0	0	G	70319378	G	G	70319378	3	3	83	1	0	0	0	0	1	0	0	0	14330	922	32	2	407	2	SHANK2	11	70319378	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	44209	70319378	64687138	67	16514											
SHANK2	22941	broad.mit.edu	37	chr11	70332717	70332717	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccctgttgagactccttCatggctcggtcccttgcgga	4	12	12	13	2	1	1	1	1	0	1	5	3	4	2	3	4	1	2	3	4	0	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:70332717C>A	uc001oqc.2	-	21	3759	c.3681G>T	c.(3679-3681)ATG>ATT	p.M1227I	SHANK2_uc010rqn.1_Missense_Mutation_p.M639I|SHANK2_uc001opz.2_Missense_Mutation_p.M632I|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	848					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GAGACTCCTTCATGGCTCGGT	0.627													25	506					3.01185e-09	3.95449e-09	1	0	A	70332717	A	A	70332717	3	1	83	1	0	0	0	0	1	0	0	0	14330	826	29	2	1876	2	SHANK2	11	70332717	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	13339	70332717	64673799	68	16515											
OR10S1	219873	broad.mit.edu	37	chr11	123847523	123847523	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttgagcattggagttacGattgtgtagaagacagcagg	11	10	16	4	1	0	3	0	1	0	2	0	5	0	4	0	3	3	5	0	3	3	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:123847523G>T	uc001pzm.1	-	1	876	c.876C>A	c.(874-876)ATC>ATA	p.I292I		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTGGAGTTACGATTGTGTAGA	0.537													33	76					2.49991e-28	3.43988e-28	1	0	T	123847523	T	T	123847523	2	4	83	1	0	0	0	0	0	0	0	1	10972	1048	37	3		3	OR10S1	11	123847523	Silent	SNP	G	TCGA-CN-6989-01A-11D-1912-08	53514806	123847523	11158993	69	16516											
ADAMTS8	11095	broad.mit.edu	37	chr11	130281312	130281312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggccctgagtggtaattacCgtcaggggggcattcctccg	6	9	14	12	3	1	1	1	1	0	0	3	1	3	1	4	5	1	2	4	5	2	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr11:130281312C>T	uc001qgg.3	-	6	2108	c.1750G>A	c.(1750-1752)GGG>AGG	p.G584R	ADAMTS8_uc001qgf.2_Missense_Mutation_p.G65R	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	584	Cys-rich.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TGGTAATTACCGTCAGGGGGG	0.587													13	30					0	0	0	0	T	130281312	T	T	130281312	3	4	83	1	0	0	0	0	1	0	0	0	272	666	23	1	935	1	ADAMTS8	11	130281312	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	6433789	130281312	4725204	70	16517											
OLR1	4973	broad.mit.edu	37	chr12	10313470	10313470	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttcccagttaaatgagcccGaggaaaataggtaacagttt	14	11	9	7	1	0	1	0	1	0	0	1	3	1	2	2	2	2	3	2	2	6	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:10313470G>A	uc001qxo.1	-	4	593	c.479C>T	c.(478-480)TCG>TTG	p.S160L	OLR1_uc010sgz.1_Intron|OLR1_uc010sha.1_Intron	NM_002543	NP_002534	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like)	160	Extracellular (Potential).|C-type lectin.				blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			ovary(1)	1						AAATGAGCCCGAGGAAAATAG	0.428													38	110					0	0	0	0	A	10313470	A	A	10313470	3	1	83	1	0	0	0	0	1	0	0	0	10917	1059	37	1	354	1	OLR1	12	10313470	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08		10313470	123538425	71	16518											
ITPR2	3709	broad.mit.edu	37	chr12	26808652	26808652	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaaagtacctcaaatgtcaGtttatttttttctttatccc	11	18	3	9	0	3	0	2	0	1	0	4	0	4	0	2	0	1	2	2	0	5	8			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:26808652G>A	uc001rhg.2	-	20	2995	c.2578C>T	c.(2578-2580)CTG>TTG	p.L860L		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	860	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCAAATGTCAGTTTATTTTTT	0.313													20	58					0	0	0	0	A	26808652	A	A	26808652	2	1	83	1	0	0	0	0	0	0	0	1	7960	1020	36	4		4	ITPR2	12	26808652	Silent	SNP	G	TCGA-CN-6989-01A-11D-1912-08	16495182	26808652	107043243	72	16519											
SLC4A8	9498	broad.mit.edu	37	chr12	51883736	51883736	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcatgacggctatcttaaagGtaatcatcctttcagtcatt	11	15	6	9	1	5	1	4	1	1	0	6	1	6	1	1	2	0	2	1	2	4	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:51883736G>A	uc001rys.1	+	19	2878	c.2700_splice	c.e19+1	p.K900_splice	SLC4A8_uc001rym.2_Splice_Site_p.K847_splice|SLC4A8_uc001ryn.2_Splice_Site_p.K847_splice|SLC4A8_uc001ryo.2_Splice_Site_p.K847_splice|SLC4A8_uc010snj.1_Splice_Site_p.K927_splice|SLC4A8_uc001ryr.2_Splice_Site_p.K900_splice	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate						bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TATCTTAAAGGTAATCATCCT	0.269													10	64					0	0	0	0	A	51883736	A	A	51883736	5	1	83	1	0	0	0	0	0	0	1	0	14723	1275	44	4	2775	4	SLC4A8	12	51883736	Splice_Site	SNP	G	TCGA-CN-6989-01A-11D-1912-08	25075084	51883736	81968159	73	16520											
SMUG1	23583	broad.mit.edu	37	chr12	54576251	54576251	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacctcaggctgtccacagaGgttccggaaaaagccccaga	12	5	11	13	1	1	2	1	0	0	2	3	4	3	3	5	3	1	2	5	3	2	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:54576251G>T	uc001sff.1	-	4	571	c.442C>A	c.(442-444)CTC>ATC	p.L148I	SMUG1_uc001sfa.1_5'Flank|SMUG1_uc001sfe.1_3'UTR|SMUG1_uc001sfg.1_Missense_Mutation_p.L148I|SMUG1_uc009znf.1_Missense_Mutation_p.L148I|SMUG1_uc001sfb.3_Intron|SMUG1_uc001sfc.3_Intron|SMUG1_uc001sfd.3_Intron	NM_014311	NP_055126	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional	148				Missing (in Ref. 3; BAC03670).	depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity				0						TGTCCACAGAGGTTCCGGAAA	0.567								BER_DNA_glycosylases					17	109					1.15088e-07	1.47725e-07	1	0	T	54576251	T	T	54576251	3	4	83	1	0	0	0	0	1	0	0	0	14882	1000	35	4	374	4	SMUG1	12	54576251	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	2692515	54576251	79275644	74	16521											
TSPAN19	144448	broad.mit.edu	37	chr12	85421708	85421708	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccatctgatttcgttgtgaAttcctatataacccaataga	12	14	6	9	1	1	3	0	2	1	1	3	3	2	3	3	0	1	1	3	0	6	7			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:85421708A>G	uc009zsj.2	-	4	334	c.233T>C	c.(232-234)ATT>ACT	p.I78T		NM_001100917	NP_001094387	P0C672	TSN19_HUMAN	tetraspanin 19	78	Helical; (Potential).					integral to membrane				ovary(1)	1						TTCGTTGTGAATTCCTATATA	0.299													3	13					0	0	0	0	G	85421708	G	G	85421708	3	3	83	1	0	0	0	0	1	0	0	0	16710	101	4	5	537	5	TSPAN19	12	85421708	Missense_Mutation	SNP	A	TCGA-CN-6989-01A-11D-1912-08	30845457	85421708	48430187	75	16522											
TXNRD1	7296	broad.mit.edu	37	chr12	104725379	104725379	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgcttgtggcctttctgAggagaaagctgtggagaagt	8	12	16	5	0	1	3	0	1	1	2	1	5	1	3	1	4	2	2	1	4	2	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:104725379A>G	uc010swk.1	+	14	1632	c.1610A>G	c.(1609-1611)GAG>GGG	p.E537G	TXNRD1_uc010swl.1_Missense_Mutation_p.E387G|TXNRD1_uc010swm.1_Missense_Mutation_p.E439G|TXNRD1_uc010swn.1_Missense_Mutation_p.E387G|TXNRD1_uc010swo.1_Missense_Mutation_p.E387G|TXNRD1_uc010swp.1_Missense_Mutation_p.E349G|TXNRD1_uc010swq.1_Missense_Mutation_p.E437G|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.E453G	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	537					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						GGCCTTTCTGAGGAGAAAGCT	0.333													4	22					0	0	0	0	G	104725379	G	G	104725379	3	3	83	1	0	0	0	0	1	0	0	0	16875	304	11	5	1678	5	TXNRD1	12	104725379	Missense_Mutation	SNP	A	TCGA-CN-6989-01A-11D-1912-08	19303671	104725379	29126516	76	16523											
RFC5	5985	broad.mit.edu	37	chr12	118467588	118467588	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccctcagttgactttccatCttcagttcgaatacatttat	9	17	4	11	1	3	1	2	1	1	0	6	2	5	1	2	0	1	2	2	0	3	7			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:118467588C>G	uc001twq.2	+	10	1009	c.884C>G	c.(883-885)TCT>TGT	p.S295C	RFC5_uc010syx.1_Missense_Mutation_p.S274C|RFC5_uc010syy.1_Missense_Mutation_p.S274C|RFC5_uc010syz.1_Missense_Mutation_p.S210C|RFC5_uc009zwr.2_Missense_Mutation_p.S292C	NM_007370	NP_031396	P40937	RFC5_HUMAN	replication factor C 5 isoform 1	295					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GACTTTCCATCTTCAGTTCGA	0.373													20	101					0	0	0	0	G	118467588	G	G	118467588	3	3	83	1	0	0	0	0	1	0	0	0	13313	913	32	2	928	2	RFC5	12	118467588	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	13742209	118467588	15384307	77	16524											
CLIP1	6249	broad.mit.edu	37	chr12	122839067	122839067	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcagcttccaccattgttcGcagctggtccattttggctt	6	14	9	12	1	0	0	0	0	0	0	3	0	2	0	3	2	3	6	3	2	0	6			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr12:122839067G>A	uc001ucg.1	-	6	1346	c.1240C>T	c.(1240-1242)CGA>TGA	p.R414*	CLIP1_uc001uch.1_Nonsense_Mutation_p.R414*|CLIP1_uc001uci.1_Nonsense_Mutation_p.R414*|CLIP1_uc001ucj.1_Nonsense_Mutation_p.R115*|CLIP1_uc009zxo.1_Nonsense_Mutation_p.R5*|CLIP1_uc010tae.1_Nonsense_Mutation_p.R348*	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	414	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		ACCATTGTTCGCAGCTGGTCC	0.507													12	60					0	0	0	0	A	122839067	A	A	122839067	4	1	83	1	0	0	0	0	0	1	0	0	3547	1095	38	1	3119	1	CLIP1	12	122839067	Nonsense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	4371479	122839067	11012828	78	16525											
FRY	10129	broad.mit.edu	37	chr13	32798468	32798468	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgtactggaggatgctgggCccccctggttgactatctcc	5	12	12	12	0	1	1	0	1	1	0	2	3	1	3	4	4	2	3	4	4	2	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr13:32798468C>A	uc001utx.2	+	37	5358	c.4862C>A	c.(4861-4863)GCC>GAC	p.A1621D	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1621					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GGATGCTGGGCCCCCCTGGTT	0.572													26	68					2.44723e-14	3.28847e-14	1	0	A	32798468	A	A	32798468	3	1	83	1	0	0	0	0	1	0	0	0	6097	739	26	4	5008	4	FRY	13	32798468	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08		32798468	82371410	79	16526											
ING1	3621	broad.mit.edu	37	chr13	111371619	111371619	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctacgagcgcttcagtcgCgagacagacggggcgcagaa	10	5	15	11	6	1	3	1	0	0	3	2	5	1	3	0	2	3	3	0	2	2	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr13:111371619C>T	uc001vri.2	+	2	1041	c.609C>T	c.(607-609)CGC>CGT	p.R203R	ING1_uc001vrf.2_Silent_p.R16R|ING1_uc001vrg.2_5'UTR|ING1_uc001vrh.2_Silent_p.R60R	NM_005537	NP_005528	Q9UK53	ING1_HUMAN	inhibitor of growth family, member 1 isoform D	203					cell cycle|negative regulation of cell growth|negative regulation of cell proliferation	nucleus	zinc ion binding			ovary(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.188)			GCTTCAGTCGCGAGACAGACG	0.647													13	91					0	0	0	0	T	111371619	T	T	111371619	2	4	83	1	0	0	0	0	0	0	0	1	7774	755	27	1		1	ING1	13	111371619	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	78573151	111371619	3798259	80	16527											
DHRS7	51635	broad.mit.edu	37	chr14	60622827	60622827	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctcctcaccaattccactCgaggctccagtcacccacac	10	7	5	19	1	2	0	2	0	0	0	6	1	5	0	5	1	1	2	5	1	1	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr14:60622827C>T	uc001xes.2	-	2	361	c.177G>A	c.(175-177)TCG>TCA	p.S59S	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Silent_p.S9S|DHRS7_uc001xeu.2_Silent_p.S59S	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	59	NAD (By similarity).						binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		CAATTCCACTCGAGGCTCCAG	0.448													10	86					0	0	0	0	T	60622827	T	T	60622827	2	4	83	1	0	0	0	0	0	0	0	1	4517	871	31	1		1	DHRS7	14	60622827	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08		60622827	46726713	81	16528											
CILP	8483	broad.mit.edu	37	chr15	65490732	65490732	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagctgtggctgtggaaataTtccggggatccaggaaggtc	9	9	15	8	1	0	0	0	0	0	0	3	3	2	3	2	6	1	2	2	6	3	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr15:65490732T>C	uc002aon.2	-	9	2073	c.1892A>G	c.(1891-1893)AAT>AGT	p.N631S		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	631					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TGTGGAAATATTCCGGGGATC	0.517													51	124					0	0	0	0	C	65490732	C	C	65490732	3	2	83	1	0	0	0	0	1	0	0	0	3444	1493	52	5	1666	5	CILP	15	65490732	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08		65490732	37040660	82	16529											
C15orf60	283677	broad.mit.edu	37	chr15	73766183	73766183	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccctttcaaggtttttgattCcaatgaagaatctggatatc	11	15	7	8	0	2	3	1	2	1	1	4	4	3	4	2	2	0	1	2	2	5	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr15:73766183C>G	uc002avq.2	+	2	198	c.170C>G	c.(169-171)TCC>TGC	p.S57C	C15orf60_uc010bjb.2_Missense_Mutation_p.S57C	NM_001042367	NP_001035826	Q7Z4M0	CO060_HUMAN	hypothetical protein LOC283677	57										pancreas(1)	1						GTTTTTGATTCCAATGAAGAA	0.323													5	6					0	0	0	0	G	73766183	G	G	73766183	3	3	83	1	0	0	0	0	1	0	0	0	1814	855	30	2	176	2	C15orf60	15	73766183	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	8275451	73766183	28765209	83	16530											
CSPG4	1464	broad.mit.edu	37	chr15	75981392	75981392	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcagagccttgggccagtcGcaaccctgtgctgcggtgga	6	7	16	12	2	0	1	0	0	0	1	1	2	0	2	3	4	4	3	3	4	1	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr15:75981392G>A	uc002baw.2	-	3	2107	c.2014C>T	c.(2014-2016)CGA>TGA	p.R672*		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	672	CSPG 3.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						TGGGCCAGTCGCAACCCTGTG	0.672													13	86					0	0	0	0	A	75981392	A	A	75981392	4	1	83	1	0	0	0	0	0	1	0	0	3977	1095	38	1	4986	1	CSPG4	15	75981392	Nonsense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	2215209	75981392	26550000	84	16531											
FSD2	123722	broad.mit.edu	37	chr15	83434772	83434772	+	Frame_Shift_Del	DEL	C	-	-																															cggactcgcaggtcgggatgCccacaacagacctgtacaag																										TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr15:83434772delC	uc002bjd.2	-	10	1732	c.1565delG	c.(1564-1566)GGCfs	p.G522fs	FSD2_uc010uol.1_Frame_Shift_Del_p.G477fs|FSD2_uc010uom.1_Frame_Shift_Del_p.G477fs	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	522	Fibronectin type-III 2.									central_nervous_system(1)	1						GGTCGGGATGCCCACAACAGA	0.597													---	---	---								-	83434772	-	-	83434772	7	5	83	1	0	1	0	1	0	0	0	0	6105	739	26	0	700	0	FSD2	15	83434772	Frame_Shift_Del	DEL	C	TCGA-CN-6989-01A-11D-1912-08	7453380	83434772	19096620	85	16532											
PEX11A	8800	broad.mit.edu	37	chr15	90226795	90226795	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggatgctgcttcagagatCggaataaaagaagtagaaag	17	7	13	4	1	1	3	1	0	0	3	2	7	1	5	0	2	2	3	0	2	6	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr15:90226795C>T	uc002boi.2	-	3	652	c.557G>A	c.(556-558)CGA>CAA	p.R186Q	PEX11A_uc010upy.1_RNA	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	186	Lumenal (Potential).				cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CTTCAGAGATCGGAATAAAAG	0.473													40	232					0	0	0	0	T	90226795	T	T	90226795	3	4	83	1	0	0	0	0	1	0	0	0	11792	884	31	1	190	1	PEX11A	15	90226795	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	6792023	90226795	12304597	86	16533											
USP31	57478	broad.mit.edu	37	chr16	23117561	23117561	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggcagaggaattggcaaaGaaatgcaaaggaaaggatca	18	4	15	4	0	1	2	1	0	0	2	1	5	1	5	0	6	1	3	0	6	5	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr16:23117561G>A	uc002dll.2	-	4	926	c.926C>T	c.(925-927)TCT>TTT	p.S309F		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	309					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		AATTGGCAAAGAAATGCAAAG	0.383													6	42					0	0	0	0	A	23117561	A	A	23117561	3	1	83	1	0	0	0	0	1	0	0	0	17130	942	33	2	3184	2	USP31	16	23117561	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08		23117561	67237192	87	16534											
CDYL2	124359	broad.mit.edu	37	chr16	80654799	80654799	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttgctgtcgtctgtggctgCgttgcagagcgctcgccgga	3	12	15	11	5	1	1	0	0	1	1	3	2	1	2	1	2	4	5	1	2	0	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr16:80654799C>T	uc002ffs.2	-	4	973	c.868G>A	c.(868-870)GCA>ACA	p.A290T		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	290						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						TCTGTGGCTGCGTTGCAGAGC	0.557													9	40					0	0	0	0	T	80654799	T	T	80654799	3	4	83	1	0	0	0	0	1	0	0	0	3201	768	27	1	668	1	CDYL2	16	80654799	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	57537238	80654799	9699954	88	16535											
PELP1	27043	broad.mit.edu	37	chr17	4594214	4594214	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgaatgctccgaagccaaGacacacagtgctgctggaat	12	7	11	11	1	0	2	0	1	0	1	1	4	1	3	2	1	4	4	2	1	4	0			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:4594214G>C	uc002fyi.3	-	3	615	c.389C>G	c.(388-390)TCT>TGT	p.S130C	PELP1_uc010vsf.1_5'UTR	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	130					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						CCGAAGCCAAGACACACAGTG	0.537													12	53					0	0	0	0	C	4594214	C	C	4594214	3	2	83	1	0	0	0	0	1	0	0	0	11779	942	33	2	3063	2	PELP1	17	4594214	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08		4594214	76600996	89	16536											
TP53	7157	broad.mit.edu	37	chr17	7577516	7577517	+	Frame_Shift_Ins	INS	-	A	A																															acctggagtcttccagtgtgINSatgatggtgaggatgggcct																										TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:7577516_7577517insA	uc002gim.2	-	7	958_959	c.764_765insT	c.(763-765)ATCfs	p.I255fs	TP53_uc002gig.1_Frame_Shift_Ins_p.I255fs|TP53_uc002gih.2_Frame_Shift_Ins_p.I255fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.I123fs|TP53_uc010cng.1_Frame_Shift_Ins_p.I123fs|TP53_uc002gii.1_Frame_Shift_Ins_p.I123fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.I255fs|TP53_uc010cni.1_Frame_Shift_Ins_p.I255fs|TP53_uc002gij.2_Frame_Shift_Ins_p.I255fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Ins_p.I162fs|TP53_uc002gio.2_Frame_Shift_Ins_p.I123fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	255	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		I -> T (in sporadic cancers; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> M (in sporadic cancers; somatic mutation).|I -> V (in sporadic cancers; somatic mutation).|I -> N (in sporadic cancers; somatic mutation).|I -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.I255F(16)|p.0?(7)|p.I255del(7)|p.I255S(7)|p.I255N(7)|p.I255T(7)|p.I255fs*90(4)|p.I255fs*9(3)|p.I255V(3)|p.T253_I255del(2)|p.I255I(2)|p.I255fs*8(1)|p.?(1)|p.T256fs*8(1)|p.I254fs*7(1)|p.I255M(1)|p.R249_T256delRPILTIIT(1)|p.T256fs*17(1)|p.I254_T256del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTCCAGTGTGATGATGGTGAG	0.584		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								A	7577517	A	A	7577516	7	5	83	1	0	1	1	0	0	0	0	0	16448	1280	45	0	525	0	TP53	17	7577516	Frame_Shift_Ins	INS	-	TCGA-CN-6989-01A-11D-1912-08	2983302	7577516	73617694	90	16537											
DNAH9	1770	broad.mit.edu	37	chr17	11572997	11572997	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggctggaacccatcaaggTgtttgacggctggatgaaaa	12	8	13	8	1	1	2	1	2	0	0	1	4	1	4	1	5	1	3	1	5	4	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:11572997T>G	uc002gne.2	+	17	3307	c.3239T>G	c.(3238-3240)GTG>GGG	p.V1080G	DNAH9_uc010coo.2_Missense_Mutation_p.V374G	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1080	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCCATCAAGGTGTTTGACGGC	0.468													21	150					0	0	0	0	G	11572997	G	G	11572997	3	3	83	1	0	0	0	0	1	0	0	0	4630	1696	59	5	3305	5	DNAH9	17	11572997	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	3995481	11572997	69622213	91	16538											
NF1	4763	broad.mit.edu	37	chr17	29586061	29586061	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attgtgtagatacttcagagTattgccaatcatgttctctt	10	17	7	7	0	3	2	2	0	1	2	4	2	3	2	1	0	2	3	1	0	4	8			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:29586061T>A	uc002hgg.2	+	33	4677	c.4344T>A	c.(4342-4344)AGT>AGA	p.S1448R	NF1_uc002hgh.2_Missense_Mutation_p.S1427R|NF1_uc002hgi.1_Missense_Mutation_p.S460R	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1448	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(3)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TACTTCAGAGTATTGCCAATC	0.313			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			4	14					0	0	0	0	A	29586061	A	A	29586061	3	1	83	1	0	0	0	0	1	0	0	0	10410	1635	57	5	4535	5	NF1	17	29586061	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	18013064	29586061	51609149	92	16539											
LRRC37B	114659	broad.mit.edu	37	chr17	30349724	30349724	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcctccacaagcaccaacaTatgtgagctctgcacctgcg	10	7	9	15	1	1	1	0	1	1	0	2	1	2	1	4	1	5	3	4	1	3	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:30349724T>G	uc002hgu.2	+	1	1570	c.1559T>G	c.(1558-1560)ATA>AGA	p.I520R	LRRC37B_uc010wbx.1_Missense_Mutation_p.I438R|LRRC37B_uc010csu.2_Missense_Mutation_p.I520R	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	520	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				AGCACCAACATATGTGAGCTC	0.537													57	164					0	0	0	0	G	30349724	G	G	30349724	3	3	83	1	0	0	0	0	1	0	0	0	9044	1406	49	5	1561	5	LRRC37B	17	30349724	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	763663	30349724	50845486	93	16540											
UBTF	7343	broad.mit.edu	37	chr17	42288993	42288993	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctgatcacacttcttgtgaTaggcgtccttctccttctgg	5	15	8	13	1	4	2	1	2	3	0	6	2	5	2	3	2	0	0	3	2	1	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:42288993T>C	uc002igb.2	-	9	1095	c.1028A>G	c.(1027-1029)TAT>TGT	p.Y343C	UBTF_uc002igc.2_Missense_Mutation_p.Y306C|UBTF_uc010czs.2_Missense_Mutation_p.Y343C|UBTF_uc002igd.2_Missense_Mutation_p.Y306C|UBTF_uc010czt.2_Missense_Mutation_p.Y343C|UBTF_uc002ige.2_Missense_Mutation_p.Y306C	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	343	HMG box 3.				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CTTCTTGTGATAGGCGTCCTT	0.587													31	134					0	0	0	0	C	42288993	C	C	42288993	3	2	83	1	0	0	0	0	1	0	0	0	16977	1406	49	5	1314	5	UBTF	17	42288993	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	11939269	42288993	38906217	94	16541											
LRRC37A2	474170	broad.mit.edu	37	chr17	44626341	44626341	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaagacttaacccacgctaTttccattttagaaagtgcaa	15	11	6	9	1	0	2	0	0	0	2	1	3	1	2	2	0	2	2	2	0	6	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:44626341T>C	uc002ikn.1	+	9	3839	c.3836T>C	c.(3835-3837)ATT>ACT	p.I1279T	ARL17A_uc002iko.3_Intron|LRRC37A2_uc002ikq.1_Missense_Mutation_p.I240T|LRRC37A2_uc010dax.1_Missense_Mutation_p.I209T	NM_001006607	NP_001006608	A6NM11	L37A2_HUMAN	c114 SLIT-like testicular protein precursor	1279	Extracellular (Potential).					integral to membrane					0		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		ACCCACGCTATTTCCATTTTA	0.468													18	96					0	0	0	0	C	44626341	C	C	44626341	3	2	83	1	0	0	0	0	1	0	0	0	9042	1493	52	5	3870	5	LRRC37A2	17	44626341	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	2337348	44626341	36568869	95	16542											
AKAP1	8165	broad.mit.edu	37	chr17	55196358	55196358	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcaggtgacaagttacagtCcaactggtcttcctctgatt	9	14	8	10	0	3	2	1	2	2	0	5	2	5	2	2	2	2	1	2	2	3	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:55196358C>T	uc002iux.2	+	10	2821	c.2590C>T	c.(2590-2592)CCA>TCA	p.P864S	AKAP1_uc010wnl.1_Missense_Mutation_p.P864S|AKAP1_uc010dcm.2_Missense_Mutation_p.P864S	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	864					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					AAGTTACAGTCCAACTGGTCT	0.333													70	261					0	0	0	0	T	55196358	T	T	55196358	3	4	83	1	0	0	0	0	1	0	0	0	445	855	30	2	2624	2	AKAP1	17	55196358	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	10570017	55196358	25998852	96	16543											
FAM20A	54757	broad.mit.edu	37	chr17	66536060	66536060	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtgaataaggaacccatCatccccgaacttggtgaaca	15	7	9	10	1	1	2	1	2	0	0	2	4	2	3	3	3	3	0	3	3	6	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:66536060C>T	uc002jho.2	-	9	1555	c.1267G>A	c.(1267-1269)GAT>AAT	p.D423N	FAM20A_uc010wqp.1_Missense_Mutation_p.D285N|PRKAR1A_uc002jhm.2_Intron|FAM20A_uc002jhn.2_Missense_Mutation_p.D134N	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	423						extracellular region					0	Breast(10;1.64e-13)					AGGAACCCATCATCCCCGAAC	0.567													8	49					0	0	0	0	T	66536060	T	T	66536060	3	4	83	1	0	0	0	0	1	0	0	0	5565	826	29	2	370	2	FAM20A	17	66536060	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	11339702	66536060	14659150	97	16544											
ABCA9	10350	broad.mit.edu	37	chr17	66978771	66978771	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcaacttatagaccatcAgggaggagaacctgcgaaga	15	5	12	9	1	1	3	1	0	0	3	1	6	1	4	2	3	3	1	2	3	5	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr17:66978771A>G	uc002jhu.2	-	37	4795	c.4652T>C	c.(4651-4653)CTG>CCG	p.L1551P	ABCA9_uc010dez.2_Missense_Mutation_p.L1513P	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1551					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					ATAGACCATCAGGGAGGAGAA	0.433													3	106					0	0	0	0	G	66978771	G	G	66978771	3	3	83	1	0	0	0	0	1	0	0	0	39	188	7	5	234	5	ABCA9	17	66978771	Missense_Mutation	SNP	A	TCGA-CN-6989-01A-11D-1912-08	442711	66978771	14216439	98	16545											
SMCHD1	23347	broad.mit.edu	37	chr18	2673310	2673310	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcggaattaattgacaattCattgtctgctacttctcgta	10	16	7	8	2	3	1	1	1	2	0	4	2	3	2	0	1	3	2	0	1	5	7			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr18:2673310C>G	uc002klm.3	+	4	644	c.455C>G	c.(454-456)TCA>TGA	p.S152*		NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	152					chromosome organization		ATP binding				0						ATTGACAATTCATTGTCTGCT	0.328													8	22					0	0	0	0	G	2673310	G	G	2673310	4	3	83	1	0	0	0	0	0	1	0	0	14852	838	29	2	469	2	SMCHD1	18	2673310	Nonsense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08		2673310	75403938	99	16546											
CDH2	1000	broad.mit.edu	37	chr18	25532209	25532209	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcctgctcaccaccactacTtgaggaattaagggagctca	11	9	9	12	0	2	1	2	1	0	0	3	3	3	3	3	2	3	2	3	2	3	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr18:25532209T>G	uc002kwg.2	-	16	3088	c.2629A>C	c.(2629-2631)AGT>CGT	p.S877R	CDH2_uc010xbn.1_Missense_Mutation_p.S846R	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	877	Ser-rich.|Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						CCACCACTACTTGAGGAATTA	0.507											OREG0003876	type=REGULATORY REGION|Gene=CDH2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	15	95					0	0	0	0	G	25532209	G	G	25532209	3	3	83	1	0	0	0	0	1	0	0	0	3120	1609	56	5	95	5	CDH2	18	25532209	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	22858899	25532209	52545039	100	16547											
FAM59A	64762	broad.mit.edu	37	chr18	29867548	29867548	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acggacagcccgtgaatactCatcgatgtcgaactgttctt	10	11	9	11	4	2	1	1	1	1	0	4	4	2	2	1	1	3	1	1	1	3	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr18:29867548C>T	uc002kxl.2	-	4	1068	c.1012G>A	c.(1012-1014)GAG>AAG	p.E338K	FAM59A_uc002kxk.1_Missense_Mutation_p.E338K	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	338										ovary(1)|skin(1)	2						CGTGAATACTCATCGATGTCG	0.547													13	103					0	0	0	0	T	29867548	T	T	29867548	3	4	83	1	0	0	0	0	1	0	0	0	5624	835	29	2	1627	2	FAM59A	18	29867548	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	4335339	29867548	48209700	101	16548											
NOL4	8715	broad.mit.edu	37	chr18	31538215	31538215	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggactcacattaaaagctttCagccgctcggcttcaacgcc	10	9	8	14	3	3	0	3	0	0	0	4	1	3	1	2	2	3	3	2	2	3	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr18:31538215C>T	uc010dmi.2	-	7	1453	c.1224G>A	c.(1222-1224)CTG>CTA	p.L408L	NOL4_uc010xbs.1_Silent_p.L123L|NOL4_uc002kxr.3_Silent_p.L244L|NOL4_uc010xbt.1_Silent_p.L334L|NOL4_uc010dmh.2_Silent_p.L334L|NOL4_uc010xbu.1_Silent_p.L408L|NOL4_uc002kxt.3_Silent_p.L408L|NOL4_uc010xbv.1_Silent_p.L157L|NOL4_uc010xbw.1_Silent_p.L294L	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	408						nucleolus	RNA binding			ovary(3)	3						TAAAAGCTTTCAGCCGCTCGG	0.448													40	85					0	0	0	0	T	31538215	T	T	31538215	2	4	83	1	0	0	0	0	0	0	0	1	10578	813	29	2		2	NOL4	18	31538215	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	1670667	31538215	46539033	102	16549											
MEX3D	399664	broad.mit.edu	37	chr19	1556787	1556788	+	Missense_Mutation	DNP	GC	TT	TT																															ggatgatggagaagtgttcgGccgccgacaggatctcacgc																										TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:1556787_1556788GC>TT	uc010dsn.2	-	2	730_731	c.730_731GC>AA	c.(730-732)GCC>AAC	p.A244N		NM_203304	NP_976049	Q86XN8	MEX3D_HUMAN	ring finger and KH domain containing 1	244					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGTGTTCGGCCGCCGACAGG	0.688													19	49					0	0	0	0	TT	1556788	TT	TT	1556787	3	4	83	1	0	0	0	0	1	0	0	0	9565	1203	42	4	1291	4	MEX3D	19	1556787	Missense_Mutation	DNP	GC	TCGA-CN-6989-01A-11D-1912-08		1556787	57572196	103	16550											
OR2Z1	284383	broad.mit.edu	37	chr19	8841649	8841649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agatggcatcagactttctgCggggagaaggtgccacctcc	9	8	13	11	1	2	3	1	0	1	3	3	4	3	3	3	4	2	1	3	4	1	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:8841649C>T	uc010xkg.1	+	1	259	c.259C>T	c.(259-261)CGG>TGG	p.R87W		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						AGACTTTCTGCGGGGAGAAGG	0.552													19	74					0	0	0	0	T	8841649	T	T	8841649	3	4	83	1	0	0	0	0	1	0	0	0	11090	759	27	1	261	1	OR2Z1	19	8841649	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	7284862	8841649	50287334	104	16551											
ANGPTL6	83854	broad.mit.edu	37	chr19	10203335	10203335	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaccacgaaactcagccCagtagacaccatcctggtag	12	5	7	17	1	1	1	1	0	0	1	2	2	2	1	6	1	2	2	6	1	3	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:10203335C>G	uc002mmx.1	-	6	1461	c.1343G>C	c.(1342-1344)TGG>TCG	p.W448S	C19orf66_uc002mmu.3_3'UTR|C19orf66_uc002mmv.3_3'UTR|C19orf66_uc002mmw.3_3'UTR|ANGPTL6_uc002mmy.1_Missense_Mutation_p.W448S	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	448	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			AAACTCAGCCCAGTAGACACC	0.617													28	83					0	0	0	0	G	10203335	G	G	10203335	3	3	83	1	0	0	0	0	1	0	0	0	618	595	21	4	73	4	ANGPTL6	19	10203335	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	1361686	10203335	48925648	105	16552											
ZNF208	7757	broad.mit.edu	37	chr19	22157159	22157159	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttacatctgtagggtttcTctccagtatgagcactctta	8	16	7	10	0	3	1	0	1	3	0	5	1	4	1	1	1	2	4	1	1	4	6			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:22157159T>C	uc002nqp.2	-	4	826	c.677A>G	c.(676-678)GAG>GGG	p.E226G	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTAGGGTTTCTCTCCAGTATG	0.358													15	57					0	0	0	0	C	22157159	C	C	22157159	3	2	83	1	0	0	0	0	1	0	0	0	17833	1551	54	5	3169	5	ZNF208	19	22157159	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	11953824	22157159	36971824	106	16553											
DPY19L3	147991	broad.mit.edu	37	chr19	32930743	32930743	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagtctgacatggcaatttaAtcaatttatgatgctgatgc	12	15	8	6	0	2	3	1	3	1	0	2	3	2	3	0	1	2	2	0	1	5	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:32930743A>G	uc002ntg.2	+	8	958	c.782A>G	c.(781-783)AAT>AGT	p.N261S	DPY19L3_uc002nth.1_Missense_Mutation_p.N261S|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	261	Helical; (Potential).					integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					TGGCAATTTAATCAATTTATG	0.388													28	49					0	0	0	0	G	32930743	G	G	32930743	3	3	83	1	0	0	0	0	1	0	0	0	4764	101	4	5	808	5	DPY19L3	19	32930743	Missense_Mutation	SNP	A	TCGA-CN-6989-01A-11D-1912-08	10773584	32930743	26198240	107	16554											
ZSCAN5A	79149	broad.mit.edu	37	chr19	56734095	56734095	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacgtcaatactcttgtgtaGcagaaagtcctctccctgaa	11	12	7	11	1	3	2	1	1	2	1	5	2	4	2	2	0	3	2	2	0	6	4			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr19:56734095G>A	uc002qmq.2	-	4	770	c.604C>T	c.(604-606)CTA>TTA	p.L202L	ZSCAN5A_uc010ygi.1_Silent_p.L85L|ZSCAN5A_uc002qmr.2_Silent_p.L202L|ZSCAN5A_uc002qms.1_Silent_p.L202L	NM_024303	NP_077279	Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	202					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CTCTTGTGTAGCAGAAAGTCC	0.488													17	68					0	0	0	0	A	56734095	A	A	56734095	2	1	83	1	0	0	0	0	0	0	0	1	18305	962	34	4		4	ZSCAN5A	19	56734095	Silent	SNP	G	TCGA-CN-6989-01A-11D-1912-08	23803352	56734095	2394888	108	16555											
C20orf30	29058	broad.mit.edu	37	chr20	5086842	5086842	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcagcttacccctttgcTgatgtagcctgacagcagga	8	10	10	13	1	1	2	1	2	0	0	1	3	1	3	4	1	5	4	4	1	2	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:5086842T>G	uc002wll.2	-	4	680	c.214A>C	c.(214-216)AGC>CGC	p.S72R	C20orf30_uc010gbi.2_Missense_Mutation_p.S72R|C20orf30_uc002wlk.2_Missense_Mutation_p.S135R|C20orf30_uc002wlm.2_Missense_Mutation_p.S72R|C20orf30_uc002wln.2_Missense_Mutation_p.S72R|C20orf30_uc002wlo.2_RNA	NM_001009924	NP_001009924	Q96A57	CT030_HUMAN	hypothetical protein LOC29058 isoform 2	72						integral to membrane					0						ACCCCTTTGCTGATGTAGCCT	0.388													3	85					0	0	0	0	G	5086842	G	G	5086842	3	3	83	1	0	0	0	0	1	0	0	0	2120	1580	55	5	156	5	C20orf30	20	5086842	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08		5086842	57938678	109	16556											
C20orf26	26074	broad.mit.edu	37	chr20	20054956	20054956	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttctgcagcccctgaataCgttgttcatgcacctctttg	6	15	7	13	1	4	1	1	1	3	0	4	1	4	1	3	0	4	4	3	0	2	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:20054956C>G	uc002wru.2	+	4	381	c.305C>G	c.(304-306)ACG>AGG	p.T102R	C20orf26_uc010gcw.1_Missense_Mutation_p.T56R|C20orf26_uc010zse.1_Missense_Mutation_p.T102R|C20orf26_uc010zsf.1_Missense_Mutation_p.T102R	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	102										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCCCTGAATACGTTGTTCATG	0.512													33	113					0	0	0	0	G	20054956	G	G	20054956	3	3	83	1	0	0	0	0	1	0	0	0	2116	536	19	3	315	3	C20orf26	20	20054956	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	14968114	20054956	42970564	110	16557											
CST1	1469	broad.mit.edu	37	chr20	23731396	23731396	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactcatcattgaggtctgcGttatagatgccacccgggat	9	11	10	11	2	3	2	2	1	1	1	3	3	3	3	2	2	2	1	2	2	2	3	rs143815991		TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:23731396G>T	uc002wtp.2	-	1	179	c.108C>A	c.(106-108)AAC>AAA	p.N36K		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	36						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					TGAGGTCTGCGTTATAGATGC	0.572													7	63					1.12685e-05	1.41473e-05	1	0	T	23731396	T	T	23731396	3	4	83	1	0	0	0	0	1	0	0	0	3987	1136	40	3	329	3	CST1	20	23731396	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	3676440	23731396	39294124	111	16558											
NEURL2	140825	broad.mit.edu	37	chr20	44519120	44519120	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcatagagctggtccaagaGatggctgtagagccctggcc	9	8	13	11	0	1	3	1	0	0	3	2	4	2	3	3	3	2	3	3	3	3	2			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:44519120G>C	uc002xqg.1	-	1	782	c.511C>G	c.(511-513)CTC>GTC	p.L171V	C20orf165_uc002xqf.2_5'Flank|CTSA_uc002xqh.2_5'Flank|CTSA_uc002xqj.3_5'Flank|CTSA_uc002xqi.2_5'Flank|CTSA_uc010zxi.1_5'Flank|CTSA_uc002xqk.3_5'Flank	NM_080749	NP_542787	Q9BR09	NEUL2_HUMAN	neuralized-like protein 2	171	NHR.				intracellular signal transduction						0		Myeloproliferative disorder(115;0.0122)				TGGTCCAAGAGATGGCTGTAG	0.657											OREG0025985	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	77					0	0	0	0	C	44519120	C	C	44519120	3	2	83	1	0	0	0	0	1	0	0	0	10400	942	33	2	354	2	NEURL2	20	44519120	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	20787724	44519120	18506400	112	16559											
CSE1L	1434	broad.mit.edu	37	chr20	47704564	47704564	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctatcatgagaagtttttCtctcctacaagaagccataa	14	12	6	9	0	2	2	1	1	1	2	4	3	3	2	2	0	3	2	2	0	6	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:47704564C>A	uc002xty.2	+	17	1876	c.1742C>A	c.(1741-1743)TCT>TAT	p.S581Y	CSE1L_uc010zyg.1_Missense_Mutation_p.S364Y|CSE1L_uc010ghx.2_Missense_Mutation_p.S525Y|CSE1L_uc010ghy.2_Missense_Mutation_p.S202Y|CSE1L_uc010zyh.1_Missense_Mutation_p.S230Y	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	581					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			AGAAGTTTTTCTCTCCTACAA	0.373													11	27					2.80697e-09	3.71384e-09	1	0	A	47704564	A	A	47704564	3	1	83	1	0	0	0	0	1	0	0	0	3947	913	32	2	1804	2	CSE1L	20	47704564	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	3185444	47704564	15320956	113	16560											
CBLN4	140689	broad.mit.edu	37	chr20	54578941	54578941	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccccgggtctgacctgaTcgaagtaaatgatgcgcgtc	8	9	11	13	4	1	3	0	3	1	0	4	4	2	3	4	1	1	1	4	1	3	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr20:54578941T>G	uc002xxa.2	-	1	1072	c.287A>C	c.(286-288)GAT>GCT	p.D96A		NM_080617	NP_542184	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	96	C1q.					cell junction|extracellular region|synapse				ovary(3)|pancreas(1)	4			Colorectal(105;0.202)			TCTGACCTGATCGAAGTAAAT	0.647													30	192					0	0	0	0	G	54578941	G	G	54578941	3	3	83	1	0	0	0	0	1	0	0	0	2719	1435	50	5	330	5	CBLN4	20	54578941	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	6874377	54578941	8446579	114	16561											
ADAMTS5	11096	broad.mit.edu	37	chr21	28307044	28307044	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggggcccaggatctgctttCgtggtaggtccagcaaacag	8	8	14	11	2	1	0	0	0	1	0	3	1	2	1	2	5	3	3	2	5	2	2	rs142161826		TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr21:28307044C>A	uc002ymg.2	-	4	2159	c.1430G>T	c.(1429-1431)CGA>CTA	p.R477L		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	477					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GATCTGCTTTCGTGGTAGGTC	0.507													8	43					1.12685e-05	1.41473e-05	1	0	A	28307044	A	A	28307044	3	1	83	1	0	0	0	0	1	0	0	0	269	884	31	3	1382	3	ADAMTS5	21	28307044	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08		28307044	19822851	115	16562											
IFNAR2	3455	broad.mit.edu	37	chr21	34624976	34624976	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatgtttacagcataaacccGaaataaaaggaaacatgagt	19	9	7	6	1	0	1	0	1	0	0	0	3	0	2	1	1	4	2	1	1	8	5	rs147789575	byFrequency	TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr21:34624976G>A	uc002yrd.2	+	7	878	c.550G>A	c.(550-552)GAA>AAA	p.E184K	IFNAR2_uc002yrb.2_Missense_Mutation_p.E184K|IFNAR2_uc002yrc.2_Missense_Mutation_p.E184K|IFNAR2_uc002yre.2_Missense_Mutation_p.E184K|IFNAR2_uc002yrf.2_Missense_Mutation_p.E184K|IFNAR2_uc002yrg.2_Missense_Mutation_p.E53K|IL10RB_uc002yrh.1_Missense_Mutation_p.E34K|IL10RB_uc002yri.1_5'UTR	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	184	Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	GCATAAACCCGAAATAAAAGG	0.333													12	25					0	0	0	0	A	34624976	A	A	34624976	3	1	83	1	0	0	0	0	1	0	0	0	7584	1059	37	1	572	1	IFNAR2	21	34624976	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08	6317932	34624976	13504919	116	16563											
PIK3IP1	113791	broad.mit.edu	37	chr22	31679217	31679217	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagacaagggcagagtgatTcgctgcatctccctctcaca	10	8	10	13	1	2	3	1	1	2	2	5	3	2	3	1	1	1	4	1	1	1	1	rs145125391		TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr22:31679217T>A	uc003akm.2	-	6	835	c.645A>T	c.(643-645)CGA>CGT	p.R215R	PIK3IP1_uc003akl.2_RNA|PIK3IP1_uc011alo.1_3'UTR|PIK3IP1_uc003akn.2_Silent_p.R195R	NM_052880	NP_443112	Q96FE7	P3IP1_HUMAN	HGFL protein isoform 1	215	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						GCAGAGTGATTCGCTGCATCT	0.507													15	71					0	0	0	0	A	31679217	A	A	31679217	2	1	83	1	0	0	0	0	0	0	0	1	11972	1770	62	5		5	PIK3IP1	22	31679217	Silent	SNP	T	TCGA-CN-6989-01A-11D-1912-08		31679217	19625349	117	16564											
LARGE	9215	broad.mit.edu	37	chr22	34157394	34157394	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacaggtaaatccaggtgaTggctgggatgcagagaagac	15	6	14	6	0	0	3	0	1	0	2	1	5	1	4	1	4	2	3	1	4	4	1			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr22:34157394T>C	uc003and.3	-	3	649	c.70A>G	c.(70-72)ATC>GTC	p.I24V	LARGE_uc003ane.3_Missense_Mutation_p.I24V|LARGE_uc010gwp.2_Missense_Mutation_p.I24V|LARGE_uc011ame.1_Intron|LARGE_uc011amf.1_Missense_Mutation_p.I24V	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	24	Helical; Signal-anchor for type II membrane protein; (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				ATCCAGGTGATGGCTGGGATG	0.507													24	100					0	0	0	0	C	34157394	C	C	34157394	3	2	83	1	0	0	0	0	1	0	0	0	8667	1464	51	5	2256	5	LARGE	22	34157394	Missense_Mutation	SNP	T	TCGA-CN-6989-01A-11D-1912-08	2478177	34157394	17147172	118	16565											
PLXNB2	23654	broad.mit.edu	37	chr22	50727227	50727227	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccagacagtaccaggtcgCgcttgactctcttgtttatc	7	13	8	13	2	1	2	0	1	1	1	5	2	2	2	2	1	1	3	2	1	2	5			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chr22:50727227C>T	uc003bkv.3	-	5	1431	c.1325G>A	c.(1324-1326)CGC>CAC	p.R442H		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	442	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TACCAGGTCGCGCTTGACTCT	0.607													10	40					0	0	0	0	T	50727227	T	T	50727227	3	4	83	1	0	0	0	0	1	0	0	0	12179	768	27	1	4323	1	PLXNB2	22	50727227	Missense_Mutation	SNP	C	TCGA-CN-6989-01A-11D-1912-08	16569833	50727227	577339	119	16566											
TBX22	50945	broad.mit.edu	37	chrX	79286052	79286052	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggggccccctctcctttGaactccttactttctccact	5	13	7	16	0	2	1	0	1	2	0	5	2	3	2	5	3	2	0	5	3	2	3			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chrX:79286052G>T	uc010nmg.1	+	9	1139	c.1005G>T	c.(1003-1005)TTG>TTT	p.L335F	TBX22_uc004edi.1_Missense_Mutation_p.L215F|TBX22_uc004edj.1_Missense_Mutation_p.L335F	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	335					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CCTCTCCTTTGAACTCCTTAC	0.473													34	43					1.02151e-06	1.30148e-06	1	0	T	79286052	T	T	79286052	3	4	83	1	0	0	0	0	1	0	0	0	15724	1281	45	2	1035	2	TBX22	23	79286052	Missense_Mutation	SNP	G	TCGA-CN-6989-01A-11D-1912-08		79286052	75984508	120	16567											
NXF5	55998	broad.mit.edu	37	chrX	101092616	101092616	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttgtgtgctttagcagcttCctctgcaggtctatagagaa	8	15	10	8	0	2	1	0	0	2	1	3	2	3	1	1	1	4	4	1	1	4	6			TCGA-CN-6989-01A-11D-1912-08	TCGA-CN-6989-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	61cd2198-d85e-4eae-b9c6-e36be372595b	ac954060-b4d9-4a3c-8922-a7dcb8d79074	g.chrX:101092616C>T	uc011mrk.1	-	15	1290	c.930G>A	c.(928-930)AGG>AGA	p.R310R	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	310	NTF2; truncated.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TTAGCAGCTTCCTCTGCAGGT	0.527													5	72					0	0	0	0	T	101092616	T	T	101092616	2	4	83	1	0	0	0	0	0	0	0	1	10840	854	30	2		2	NXF5	23	101092616	Silent	SNP	C	TCGA-CN-6989-01A-11D-1912-08	21806564	101092616	54177944	121	16568											
CLCNKA	1187	broad.mit.edu	37	chr1	16357081	16357081	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctggcagccaacgccattGcacagagctgccagccctcc	8	6	10	17	1	0	1	0	0	0	1	1	1	1	1	5	1	7	4	5	1	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:16357081G>T	uc001axu.2	+	15	1614	c.1534G>T	c.(1534-1536)GCA>TCA	p.A512S	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.A512S|CLCNKA_uc010obw.1_Missense_Mutation_p.A469S|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010obx.1_Missense_Mutation_p.A159S|CLCNKA_uc010oby.1_Missense_Mutation_p.A248S	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	512					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CAACGCCATTGCACAGAGCTG	0.612													27	19					4.59853e-10	7.07551e-10	1	0	T	16357081	T	T	16357081	3	4	84	1	0	0	0	0	1	0	0	0	3484	1319	46	4	1588	4	CLCNKA	1	16357081	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08		16357081	232893540	1	16569											
NBPF1	55672	broad.mit.edu	37	chr1	16890588	16890588	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagtgctggaatgagtcaggTagttcaaagtacattgacgg	12	11	13	5	1	2	2	2	2	0	0	2	3	2	3	0	3	2	4	0	3	5	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:16890588T>A	uc009vos.1	-	31	4383	c.3495A>T	c.(3493-3495)CTA>CTT	p.L1165L	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1165	NBPF 8.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ATGAGTCAGGTAGTTCAAAGT	0.463													42	683					0	0	0	0	A	16890588	A	A	16890588	2	1	84	1	0	0	0	0	0	0	0	1	10245	1625	57	5		5	NBPF1	1	16890588	Silent	SNP	T	TCGA-CN-6992-01A-11D-1912-08	533507	16890588	232360033	2	16570											
MAP3K6	9064	broad.mit.edu	37	chr1	27684364	27684364	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggccgcaggctcctcgggCaccctgggcacaagggcgag	6	4	16	15	4	0	0	0	0	0	0	3	1	1	0	3	5	0	4	3	5	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:27684364C>A	uc001bny.1	-	22	3168	c.2919G>T	c.(2917-2919)GTG>GTT	p.V973V	MAP3K6_uc009vsw.1_Silent_p.V965V	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	973					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GCTCCTCGGGCACCCTGGGCA	0.657											OREG0013282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	2					0.00116845	0.00161804	1	0	A	27684364	A	A	27684364	2	1	84	1	0	0	0	0	0	0	0	1	9307	697	25	4		4	MAP3K6	1	27684364	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	10793776	27684364	221566257	3	16571											
DLGAP3	58512	broad.mit.edu	37	chr1	35333227	35333227	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcactgcggatcttctccagGactagaaagcagaaggaaat	14	7	11	9	1	2	2	0	0	2	2	3	5	2	5	1	3	2	2	1	3	4	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:35333227G>T	uc001byc.2	-	8	2487	c.2487C>A	c.(2485-2487)ATC>ATA	p.I829I		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	829					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				TCTTCTCCAGGACTAGAAAGC	0.557													67	23					2.73361e-28	4.961e-28	1	0	T	35333227	T	T	35333227	2	4	84	1	0	0	0	0	0	0	0	1	4583	1188	41	2		2	DLGAP3	1	35333227	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	7648863	35333227	213917394	4	16572											
OXCT2	64064	broad.mit.edu	37	chr1	40235514	40235514	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctgtgcacgtcaaacaCggccttctcggtgatgatgc	7	11	10	13	3	2	2	1	2	1	0	4	2	3	2	2	2	3	1	2	2	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:40235514C>T	uc001ceb.1	-	1	1507	c.1414G>A	c.(1414-1416)GTG>ATG	p.V472M	BMP8B_uc001cdz.1_Intron|BMP8B_uc001cea.1_Intron|OXCT2_uc009vvu.1_Missense_Mutation_p.V466M	NM_022120	NP_071403	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2 precursor	472					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			pancreas(1)	1	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	ACGTCAAACACGGCCTTCTCG	0.587													83	44					0	0	0	0	T	40235514	T	T	40235514	3	4	84	1	0	0	0	0	1	0	0	0	11384	536	19	1	143	1	OXCT2	1	40235514	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	4902287	40235514	209015107	5	16573											
RLF	6018	broad.mit.edu	37	chr1	40705148	40705148	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggagaatcttgttgtttgcGttaagtacggtaccaaaatt	11	15	10	5	2	1	1	0	0	1	1	1	2	1	1	1	2	3	5	1	2	6	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:40705148G>A	uc001cfc.3	+	8	4805	c.4774G>A	c.(4774-4776)GTT>ATT	p.V1592I	RLF_uc001cfd.3_Missense_Mutation_p.V1283I	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1592					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TGTTGTTTGCGTTAAGTACGG	0.428													21	98					0	0	0	0	A	40705148	A	A	40705148	3	1	84	1	0	0	0	0	1	0	0	0	13454	1145	40	1	4804	1	RLF	1	40705148	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	469634	40705148	208545473	6	16574											
EIF2B3	8891	broad.mit.edu	37	chr1	45453797	45453798	+	5'Flank	INS	-	AA	AA																															acagggtgagacagcgtctcINSaaaaaaaaaaaaaaaaaaaa																								rs149445248		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:45453797_45453798insAA	uc001cmt.1	-						EIF2B3_uc001cmu.1_5'Flank|EIF2B3_uc001cmv.1_5'Flank|EIF2B3_uc001cmw.2_5'Flank	NM_020365	NP_065098	Q9NR50	EI2BG_HUMAN	eukaryotic translation initiation factor 2B,						negative regulation of translational initiation in response to stress|oligodendrocyte development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	nucleotidyltransferase activity|protein binding|translation initiation factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					gacagcgtctcaaaaaaaaaaa	0.178													---	---	---								AA	45453798	AA	AA	45453797	6	5	84	0	1	1	1	0	0	0	0	0	5024	841	29	0		0	EIF2B3	1	45453797	5'Flank	INS	-	TCGA-CN-6992-01A-11D-1912-08	4748649	45453797	203796824	7	16575											
MOBKL2C	148932	broad.mit.edu	37	chr1	47078896	47078896	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acttgagagaggcctgtgccTtcttgtacagctcaaagcgc	9	10	11	11	1	2	2	1	1	1	1	2	3	2	2	2	1	4	2	2	1	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:47078896T>G	uc001cqf.3	-	2	329	c.98A>C	c.(97-99)AAG>ACG	p.K33T	MKNK1_uc010omf.1_Intron|MOBKL2C_uc001cqe.3_Missense_Mutation_p.K85T	NM_201403	NP_958805	Q70IA8	MOL2C_HUMAN	MOB1, Mps One Binder kinase activator-like 2C	33							metal ion binding			pancreas(1)	1	Acute lymphoblastic leukemia(166;0.155)					GGCCTGTGCCTTCTTGTACAG	0.637													24	18					0	0	0	0	G	47078896	G	G	47078896	3	3	84	1	0	0	0	0	1	0	0	0	9739	1609	56	5	564	5	MOBKL2C	1	47078896	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	1625099	47078896	202171725	8	16576											
ZRANB2	9406	broad.mit.edu	37	chr1	71544178	71544178	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttagcactaaataggcctcgGctcttttctgcaagtgtctt	8	15	8	10	1	3	0	0	0	3	0	4	0	3	0	1	2	2	3	1	2	5	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:71544178G>C	uc001dft.2	-	3	247	c.180C>G	c.(178-180)AGC>AGG	p.S60R	uc001dfu.1_5'Flank|ZRANB2_uc001dfs.2_Missense_Mutation_p.S60R	NM_203350	NP_976225	O95218	ZRAB2_HUMAN	zinc finger protein 265 isoform 1	60					mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						ATAGGCCTCGGCTCTTTTCTG	0.378													8	59					0	0	0	0	C	71544178	C	C	71544178	3	2	84	1	0	0	0	0	1	0	0	0	18290	1194	42	4	882	4	ZRANB2	1	71544178	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	24465282	71544178	177706443	9	16577											
C1orf103	55791	broad.mit.edu	37	chr1	111490596	111490596	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agattttatttttggtgcatCttcttacgcatttcttcaag	8	20	6	7	1	4	1	1	0	3	1	4	1	4	1	0	1	2	2	0	1	3	8			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:111490596C>T	uc001eaa.2	-	4	2551	c.2295G>A	c.(2293-2295)AAG>AAA	p.K765K	C1orf103_uc001dzz.2_Silent_p.K229K|C1orf103_uc001eab.2_Silent_p.K229K|C1orf103_uc001eac.1_Silent_p.K228K	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	765	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		TTTGGTGCATCTTCTTACGCA	0.348													20	79					0	0	0	0	T	111490596	T	T	111490596	2	4	84	1	0	0	0	0	0	0	0	1	1986	912	32	2		2	C1orf103	1	111490596	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	39946418	111490596	137760025	10	16578											
MAGI3	260425	broad.mit.edu	37	chr1	114193672	114193672	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttattcccctgggagcagctGagaaagatggtcggctccgc	8	9	13	11	2	0	2	0	1	0	2	3	4	2	3	3	3	2	3	3	3	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:114193672G>T	uc001edk.2	+	14	2465	c.2284G>T	c.(2284-2286)GAG>TAG	p.E762*	MAGI3_uc001edh.3_Nonsense_Mutation_p.E787*|MAGI3_uc001edi.3_Nonsense_Mutation_p.E762*|MAGI3_uc010owm.1_Nonsense_Mutation_p.E787*|MAGI3_uc001edj.2_Nonsense_Mutation_p.E483*	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	787	Interaction with BAI1.|PDZ 4.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGAGCAGCTGAGAAAGATGG	0.418													18	20					2.94398e-08	4.3612e-08	1	0	T	114193672	T	T	114193672	4	4	84	1	0	0	0	0	0	1	0	0	9245	1291	45	2	2338	2	MAGI3	1	114193672	Nonsense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2703076	114193672	135056949	11	16579											
SYCP1	6847	broad.mit.edu	37	chr1	115537355	115537355	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagagacattgaaaacactgTataggaacaataatccacca	20	7	6	8	0	0	2	0	1	0	1	1	4	1	3	2	1	2	1	2	1	8	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:115537355T>A	uc001efr.2	+	31	2949	c.2740T>A	c.(2740-2742)TAT>AAT	p.Y914N	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.Y914N|SYCP1_uc009wgw.2_Missense_Mutation_p.Y889N	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	914					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAAACACTGTATAGGAACAA	0.284													22	7					0	0	0	0	A	115537355	A	A	115537355	3	1	84	1	0	0	0	0	1	0	0	0	15497	1638	57	5	2858	5	SYCP1	1	115537355	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	1343683	115537355	133713266	12	16580											
SPAG17	200162	broad.mit.edu	37	chr1	118537063	118537063	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtttcccatgaccttgacCggagattaggagggacaatt	11	11	11	8	1	0	3	0	2	0	1	1	6	1	5	3	3	0	1	3	3	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:118537063C>A	uc001ehk.2	-	35	5212	c.5144G>T	c.(5143-5145)CGG>CTG	p.R1715L		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1715						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TGACCTTGACCGGAGATTAGG	0.423													13	12					1.49906e-05	2.15068e-05	1	0	A	118537063	A	A	118537063	3	1	84	1	0	0	0	0	1	0	0	0	15045	652	23	3	1583	3	SPAG17	1	118537063	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2999708	118537063	130713558	13	16581											
HMGCS2	3158	broad.mit.edu	37	chr1	120311418	120311418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgagggaggtttcctgcaccGctcttgtcagttgcagaatg	7	12	13	9	1	2	2	1	1	1	1	3	3	3	3	2	2	2	5	2	2	1	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:120311418G>A	uc001eid.2	-	1	101	c.50C>T	c.(49-51)GCG>GTG	p.A17V	HMGCS2_uc010oxj.1_Missense_Mutation_p.A17V	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	17					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		TTCCTGCACCGCTCTTGTCAG	0.517													8	25					0	0	0	0	A	120311418	A	A	120311418	3	1	84	1	0	0	0	0	1	0	0	0	7272	1087	38	1	1512	1	HMGCS2	1	120311418	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1774355	120311418	128939203	14	16582											
FCRL4	83417	broad.mit.edu	37	chr1	157551393	157551393	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcactgagcagccctccagTggctcccgcggcgacaaggc	8	4	13	16	3	0	1	0	1	0	0	2	2	2	1	3	3	3	3	3	3	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:157551393T>A	uc001fqw.2	-	7	1313	c.1177A>T	c.(1177-1179)ACT>TCT	p.T393S	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	393	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				AGCCCTCCAGTGGCTCCCGCG	0.572													33	18					0	0	0	0	A	157551393	A	A	157551393	3	1	84	1	0	0	0	0	1	0	0	0	5829	1696	59	5	394	5	FCRL4	1	157551393	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	37239975	157551393	91699228	15	16583											
FCRL1	115350	broad.mit.edu	37	chr1	157771764	157771764	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggccattgttggcctcaCaggagtagtttccagaatgt	9	11	11	10	0	1	1	1	0	0	1	2	2	2	2	4	3	0	3	4	3	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:157771764C>A	uc001frg.2	-	5	940	c.827G>T	c.(826-828)TGT>TTT	p.C276F	FCRL1_uc001frf.2_RNA|FCRL1_uc001frh.2_Missense_Mutation_p.C276F|FCRL1_uc001fri.2_Missense_Mutation_p.C276F|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	276	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GTTGGCCTCACAGGAGTAGTT	0.557													55	63					1.95512e-22	3.49835e-22	1	0	A	157771764	A	A	157771764	3	1	84	1	0	0	0	0	1	0	0	0	5826	478	17	4	556	4	FCRL1	1	157771764	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	220371	157771764	91478857	16	16584											
CD5L	922	broad.mit.edu	37	chr1	157803236	157803236	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agacagagccccatacgcccTtgtgcagcacctccagtcgc	9	6	9	17	2	0	2	0	0	0	2	2	2	1	2	5	0	4	2	5	0	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:157803236T>C	uc001frk.3	-	5	928	c.785A>G	c.(784-786)AAG>AGG	p.K262R		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	262	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCATACGCCCTTGTGCAGCAC	0.572													89	91					0	0	0	0	C	157803236	C	C	157803236	3	2	84	1	0	0	0	0	1	0	0	0	3042	1609	56	5	266	5	CD5L	1	157803236	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	31472	157803236	91447385	17	16585											
CD1C	911	broad.mit.edu	37	chr1	158263029	158263029	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cttttccatgaattggattgCcttggtagtgatagtgccct	7	16	10	8	0	0	2	0	2	0	0	1	3	1	3	3	2	2	1	3	2	3	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:158263029C>A	uc001fru.2	+	5	1209	c.917C>A	c.(916-918)GCC>GAC	p.A306D	CD1C_uc001frv.2_Intron	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	306	Helical; (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					AATTGGATTGCCTTGGTAGTG	0.398													60	197					4.66136e-34	8.58176e-34	1	0	A	158263029	A	A	158263029	3	1	84	1	0	0	0	0	1	0	0	0	2991	739	26	4	935	4	CD1C	1	158263029	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	459793	158263029	90987592	18	16586											
OR10T2	128360	broad.mit.edu	37	chr1	158368630	158368630	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaattaacagaaaaggcacCataattaccaggatgctgag	18	7	9	7	0	0	3	0	1	0	2	0	4	0	4	2	2	3	2	2	2	6	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:158368630C>G	uc010pih.1	-	1	627	c.627G>C	c.(625-627)ATG>ATC	p.M209I		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GAAAAGGCACCATAATTACCA	0.458													9	54					0	0	0	0	G	158368630	G	G	158368630	3	3	84	1	0	0	0	0	1	0	0	0	10973	594	21	4	319	4	OR10T2	1	158368630	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	105601	158368630	90881991	19	16587											
SPTA1	6708	broad.mit.edu	37	chr1	158607983	158607983	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatcaacgttgaaagtccCgctggagagcaaatcttcag	12	9	10	10	2	3	3	2	2	1	1	4	4	4	3	1	1	2	3	1	1	3	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:158607983C>T	uc001fst.1	-	36	5228	c.5029G>A	c.(5029-5031)GGG>AGG	p.G1677R		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1677	Spectrin 16.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTGAAAGTCCCGCTGGAGAGC	0.413													22	45					0	0	0	0	T	158607983	T	T	158607983	3	4	84	1	0	0	0	0	1	0	0	0	15182	652	23	1	2298	1	SPTA1	1	158607983	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	239353	158607983	90642638	20	16588											
SPTA1	6708	broad.mit.edu	37	chr1	158656328	158656328	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcctaaaggtttagaacCtggcaagataaaatgtgtca	14	13	8	6	0	1	2	1	0	0	2	2	2	2	2	2	2	1	2	2	2	7	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:158656328C>A	uc001fst.1	-	1	179	c.-20G>T	c.(-22--18)CAGGT>CATGT			NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GGTTTAGAACCTGGCAAGATA	0.328													41	50					2.26627e-22	4.04374e-22	1	0	A	158656328	A	A	158656328	1	1	84	1	0	0	0	0	0	0	0	0	15182	696	24	4		4	SPTA1	1	158656328	Translation_Start_Site	SNP	C	TCGA-CN-6992-01A-11D-1912-08	48345	158656328	90594293	21	16589											
FCER1A	2205	broad.mit.edu	37	chr1	159277544	159277544	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgttccactacagctccgcGtgagaagtactggctacaat	10	10	10	11	2	0	1	0	1	0	1	2	2	2	1	2	1	4	4	2	1	5	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:159277544G>T	uc001ftq.2	+	6	695	c.596G>T	c.(595-597)CGT>CTT	p.R199L		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	199	Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	ACAGCTCCGCGTGAGAAGTAC	0.413													51	49					1.54043e-34	2.85249e-34	1	0	T	159277544	T	T	159277544	3	4	84	1	0	0	0	0	1	0	0	0	5806	1145	40	3	614	3	FCER1A	1	159277544	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	621216	159277544	89973077	22	16590											
RXRG	6258	broad.mit.edu	37	chr1	165398110	165398110	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccgtggggcactcactgggGtatctgtgtagctggggtgg	4	11	18	8	1	2	0	1	0	1	0	3	0	3	0	1	7	1	4	1	7	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:165398110G>T	uc001gda.2	-	2	443	c.143C>A	c.(142-144)ACC>AAC	p.T48N		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	48	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	ACTCACTGGGGTATCTGTGTA	0.612													8	51					1.12685e-05	1.62032e-05	1	0	T	165398110	T	T	165398110	3	4	84	1	0	0	0	0	1	0	0	0	13830	1261	44	4	1284	4	RXRG	1	165398110	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	6120566	165398110	83852511	23	16591											
SFT2D2	375035	broad.mit.edu	37	chr1	168200757	168200757	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttcaattttaggttgtTgaggcatcttcattaagctg	8	20	8	5	0	3	1	2	1	1	0	3	1	3	1	0	2	1	4	0	2	3	9			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:168200757T>C	uc001gfi.3	+	2	132	c.69T>C	c.(67-69)GTT>GTC	p.V23V	TBX19_uc001gfj.3_Intron	NM_199344	NP_955376	O95562	SFT2B_HUMAN	SFT2 domain containing 2	23	Cytoplasmic (Potential).				protein transport|vesicle-mediated transport	integral to membrane				skin(1)	1	all_hematologic(923;0.215)					TTTAGGTTGTTGAGGCATCTT	0.348													48	52					0	0	0	0	C	168200757	C	C	168200757	2	2	84	1	0	0	0	0	0	0	0	1	14251	1799	63	5		5	SFT2D2	1	168200757	Silent	SNP	T	TCGA-CN-6992-01A-11D-1912-08	2802647	168200757	81049864	24	16592											
SELP	6403	broad.mit.edu	37	chr1	169586541	169586541	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tttcatttttattctggatgGccactaagtctgtgtagcga	8	17	9	7	1	3	0	1	0	2	0	3	2	3	1	1	2	1	1	1	2	3	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:169586541G>T	uc001ggi.3	-	3	271	c.206C>A	c.(205-207)GCC>GAC	p.A69D	SELP_uc001ggh.2_5'UTR|SELP_uc009wvr.2_Missense_Mutation_p.A69D	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	69	Extracellular (Potential).|C-type lectin.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	ATTCTGGATGGCCACTAAGTC	0.408													55	142					6.3091e-27	1.1385e-26	1	0	T	169586541	T	T	169586541	3	4	84	1	0	0	0	0	1	0	0	0	14084	1203	42	4	2342	4	SELP	1	169586541	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1385784	169586541	79664080	25	16593											
FMO4	2329	broad.mit.edu	37	chr1	171300851	171300851	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaggctttcagggcaaacGcgtcttggtgattggtcttg	8	12	14	7	2	3	2	1	1	2	1	3	2	3	2	0	4	1	2	0	4	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:171300851G>A	uc001gho.2	+	6	774	c.557G>A	c.(556-558)CGC>CAC	p.R186H		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	186					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CAGGGCAAACGCGTCTTGGTG	0.463													25	153					0	0	0	0	A	171300851	A	A	171300851	3	1	84	1	0	0	0	0	1	0	0	0	5989	1087	38	1	571	1	FMO4	1	171300851	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1714310	171300851	77949770	26	16594											
PAPPA2	60676	broad.mit.edu	37	chr1	176758976	176758976	+	Frame_Shift_Del	DEL	G	-	-																															agatacaatgcctggaaggtGgaatctgggagcaaggcagc																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:176758976delG	uc001gkz.2	+	18	5911	c.4747delG	c.(4747-4749)GGAfs	p.G1583fs	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1583	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCTGGAAGGTGGAATCTGGGA	0.458													---	---	---								-	176758976	-	-	176758976	7	5	84	1	0	1	0	1	0	0	0	0	11487	1349	47	0	4866	0	PAPPA2	1	176758976	Frame_Shift_Del	DEL	G	TCGA-CN-6992-01A-11D-1912-08	5458125	176758976	72491645	27	16595											
RALGPS2	55103	broad.mit.edu	37	chr1	178871291	178871291	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgataggatggatggtgatGatggctgatgaccctgaaca	11	10	15	5	0	0	6	0	6	0	0	0	8	0	8	1	4	1	1	1	4	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:178871291G>A	uc001glz.2	+	18	1913	c.1575G>A	c.(1573-1575)ATG>ATA	p.M525I	RALGPS2_uc010pnb.1_Missense_Mutation_p.M499I	NM_152663	NP_689876	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	525	Required for stimulation of nucleotide exchange by RALA (By similarity).|PH.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding				0						GGATGGTGATGATGGCTGATG	0.383													10	86					0	0	0	0	A	178871291	A	A	178871291	3	1	84	1	0	0	0	0	1	0	0	0	13083	1290	45	2	1641	2	RALGPS2	1	178871291	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2112315	178871291	70379330	28	16596											
CACNA1E	777	broad.mit.edu	37	chr1	181702849	181702849	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgtcaccgtcgccatcccCgacgtggaccccttggtgga	6	7	12	16	5	1	0	1	0	0	0	3	3	2	2	6	3	1	0	6	3	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:181702849C>T	uc001gow.2	+	21	3390	c.3225C>T	c.(3223-3225)CCC>CCT	p.P1075P	CACNA1E_uc009wxs.2_Silent_p.P963P|CACNA1E_uc001gox.1_Silent_p.P301P|CACNA1E_uc009wxt.2_Silent_p.P301P	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1075	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCGCCATCCCCGACGTGGACC	0.652													12	28					0	0	0	0	T	181702849	T	T	181702849	2	4	84	1	0	0	0	0	0	0	0	1	2554	639	23	1		1	CACNA1E	1	181702849	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2831558	181702849	67547772	29	16597											
CRB1	23418	broad.mit.edu	37	chr1	197390857	197390857	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcttaacttctataatatGccatccacaccttcgtttgt	9	16	4	12	1	1	0	0	0	1	0	3	0	2	0	3	0	3	2	3	0	4	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:197390857G>A	uc001gtz.2	+	6	2034	c.1899G>A	c.(1897-1899)ATG>ATA	p.M633I	CRB1_uc010poz.1_Missense_Mutation_p.M564I|CRB1_uc010ppa.1_Intron|CRB1_uc009wza.2_Missense_Mutation_p.M521I|CRB1_uc010ppb.1_Missense_Mutation_p.M633I|CRB1_uc010ppc.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.M114I|CRB1_uc001gub.1_Missense_Mutation_p.M282I	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	633	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TCTATAATATGCCATCCACAC	0.403													44	87					0	0	0	0	A	197390857	A	A	197390857	3	1	84	1	0	0	0	0	1	0	0	0	3863	1319	46	4	1921	4	CRB1	1	197390857	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	15688008	197390857	51859764	30	16598											
FAM58B	339521	broad.mit.edu	37	chr1	200183121	200183121	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcttccaggtctccttccagCatccacacaagtacctgctc	8	10	6	17	0	1	0	0	0	1	0	6	0	4	0	5	1	3	4	5	1	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:200183121C>A	uc009wzi.1	+	1	466	c.430C>A	c.(430-432)CAT>AAT	p.H144N		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	144					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					CTCCTTCCAGCATCCACACAA	0.612													25	35					9.86323e-18	1.67543e-17	1	0	A	200183121	A	A	200183121	3	1	84	1	0	0	0	0	1	0	0	0	5623	710	25	4	432	4	FAM58B	1	200183121	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2792264	200183121	49067500	31	16599											
ATP2B4	493	broad.mit.edu	37	chr1	203708793	203708793	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatagaggaggagttgccAcgaacaccactcctggatga	12	6	12	11	1	0	2	0	1	0	1	1	6	1	5	4	3	2	1	4	3	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:203708793A>G	uc001gzw.2	+	21	4313	c.3429A>G	c.(3427-3429)CCA>CCG	p.P1143P	ATP2B4_uc001gzv.2_3'UTR|ATP2B4_uc001gzx.2_Silent_p.P210P|ATP2B4_uc009xar.2_3'UTR	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1179	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AGGAGTTGCCACGAACACCAC	0.502													23	51					0	0	0	0	G	203708793	G	G	203708793	2	3	84	1	0	0	0	0	0	0	0	1	1144	146	6	5		5	ATP2B4	1	203708793	Silent	SNP	A	TCGA-CN-6992-01A-11D-1912-08	3525672	203708793	45541828	32	16600											
KCNH1	3756	broad.mit.edu	37	chr1	211263942	211263942	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caattggctgtttgaaagctGttatgtcactgaaagtgcaa	12	13	10	6	0	1	2	1	2	0	0	1	2	1	2	0	1	2	5	0	1	5	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:211263942G>A	uc001hib.2	-	4	571	c.401C>T	c.(400-402)ACA>ATA	p.T134I	KCNH1_uc001hic.2_Missense_Mutation_p.T134I	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	134	PAC.|Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TTTGAAAGCTGTTATGTCACT	0.358													18	24					0	0	0	0	A	211263942	A	A	211263942	3	1	84	1	0	0	0	0	1	0	0	0	8070	1377	48	4	2600	4	KCNH1	1	211263942	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	7555149	211263942	37986679	33	16601											
SIPA1L2	57568	broad.mit.edu	37	chr1	232577560	232577560	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttccctctccctggctccGtcacattccaaagggcctga	6	11	7	17	1	3	1	1	1	2	0	7	1	6	1	5	2	0	1	5	2	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:232577560G>A	uc001hvg.2	-	11	3650	c.3492C>T	c.(3490-3492)GAC>GAT	p.D1164D	SIPA1L2_uc001hvf.2_Silent_p.D238D	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1164					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCCTGGCTCCGTCACATTCCA	0.567													5	29					0	0	0	0	A	232577560	A	A	232577560	2	1	84	1	0	0	0	0	0	0	0	1	14395	1136	40	1		1	SIPA1L2	1	232577560	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	21313618	232577560	16673061	34	16602											
CHRM3	1131	broad.mit.edu	37	chr1	240072502	240072502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcggtcatttttcacaagcGcgcacccgagcaggccttgt	7	10	11	13	4	2	0	2	0	0	0	3	1	2	0	2	2	2	2	2	2	1	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:240072502G>A	uc001hyp.2	+	5	2530	c.1751G>A	c.(1750-1752)CGC>CAC	p.R584H		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	584	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TTTCACAAGCGCGCACCCGAG	0.522													9	40					0	0	0	0	A	240072502	A	A	240072502	3	1	84	1	0	0	0	0	1	0	0	0	3393	1087	38	1	1753	1	CHRM3	1	240072502	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	7494942	240072502	9178119	35	16603											
HNRNPU	3192	broad.mit.edu	37	chr1	245026026	245026026	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgcctttctgttctgttttgCcgtcccctaaaacacacacg	7	13	6	15	3	2	0	0	0	2	0	3	0	3	0	4	0	2	2	4	0	2	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:245026026C>G	uc001iaz.1	-	2	916	c.698G>C	c.(697-699)GGC>GCC	p.G233A	HNRNPU_uc001iax.1_5'Flank|HNRNPU_uc001iay.1_5'Flank|HNRNPU_uc001iba.1_Missense_Mutation_p.G214A|HNRNPU_uc001ibb.1_5'UTR	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	233					CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			TTCTGTTTTGCCGTCCCCTAA	0.443													47	77					0	0	0	0	G	245026026	G	G	245026026	3	3	84	1	0	0	0	0	1	0	0	0	7312	739	26	4	1831	4	HNRNPU	1	245026026	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	4953524	245026026	4224595	36	16604											
OR2W5	441932	broad.mit.edu	37	chr1	247655122	247655122	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtgctgaggatgaagtcagCagcagggcgaaagaaagcct	13	5	16	7	1	1	3	1	2	0	1	1	5	1	4	1	3	4	3	1	3	3	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:247655122C>A	uc001icz.1	+	1	693	c.693C>A	c.(691-693)AGC>AGA	p.S231R		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			ATGAAGTCAGCAGCAGGGCGA	0.577													27	61					1.42536e-11	2.26422e-11	1	0	A	247655122	A	A	247655122	3	1	84	1	0	0	0	0	1	0	0	0	11088	709	25	4	695	4	OR2W5	1	247655122	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2629096	247655122	1595499	37	16605											
OR2M2	391194	broad.mit.edu	37	chr1	248343988	248343988	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgggatctggagagggtcGttgcaaagctttcacgacct	9	10	13	9	2	2	1	1	0	1	1	3	4	2	2	1	3	2	3	1	3	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr1:248343988G>A	uc010pzf.1	+	1	701	c.701G>A	c.(700-702)CGT>CAT	p.R234H		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGAGAGGGTCGTTGCAAAGCT	0.468													46	49					0	0	0	0	A	248343988	A	A	248343988	3	1	84	1	0	0	0	0	1	0	0	0	11064	1145	40	1	703	1	OR2M2	1	248343988	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	688866	248343988	906633	38	16606											
GREB1	9687	broad.mit.edu	37	chr2	11750844	11750844	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgcacagcgcggtgatcagGacctttgttctcgtgcagca	7	10	12	12	3	2	1	1	1	1	0	3	2	2	2	1	2	4	4	1	2	0	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:11750844G>T	uc002rbk.1	+	18	2997	c.2697G>T	c.(2695-2697)AGG>AGT	p.R899S	GREB1_uc002rbo.1_Missense_Mutation_p.R533S|GREB1_uc002rbp.1_5'Flank	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	899						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CGGTGATCAGGACCTTTGTTC	0.642													13	40					1.5842e-08	2.36332e-08	1	0	T	11750844	T	T	11750844	3	4	84	1	0	0	0	0	1	0	0	0	6799	1165	41	2	2871	2	GREB1	2	11750844	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08		11750844	231448529	39	16607											
ATAD2B	54454	broad.mit.edu	37	chr2	23980963	23980963	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctccgccttgattttctccGaacccgaactgttttacaag	8	14	6	13	3	2	1	0	1	2	0	4	3	2	1	4	0	3	1	4	0	4	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:23980963G>A	uc002rek.3	-	25	3697	c.3403C>T	c.(3403-3405)CGG>TGG	p.R1135W	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Missense_Mutation_p.R375W|ATAD2B_uc002rej.3_Missense_Mutation_p.R303W	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1135							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATTTTCTCCGAACCCGAACT	0.323													9	43					0	0	0	0	A	23980963	A	A	23980963	3	1	84	1	0	0	0	0	1	0	0	0	1074	1057	37	1	989	1	ATAD2B	2	23980963	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	12230119	23980963	219218410	40	16608											
MFSD2B	388931	broad.mit.edu	37	chr2	24247090	24247090	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgcatcctcatggtcggctCcactccaaagacacccagtc	9	8	7	17	1	1	1	1	0	0	1	6	1	4	1	4	2	1	2	4	2	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:24247090C>T	uc002reo.1	+	13	1453	c.1439C>T	c.(1438-1440)TCC>TTC	p.S480F		NM_001080473	NP_001073942	A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing	480					transport	integral to membrane				ovary(2)	2						ATGGTCGGCTCCACTCCAAAG	0.647													3	16					0	0	0	0	T	24247090	T	T	24247090	3	4	84	1	0	0	0	0	1	0	0	0	9584	855	30	2	1489	2	MFSD2B	2	24247090	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	266127	24247090	218952283	41	16609											
THADA	63892	broad.mit.edu	37	chr2	43801646	43801646	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaagtctcatgccactggtCaatccaagaactctcagcag	12	8	7	14	0	3	1	3	0	2	1	6	1	4	1	3	1	3	1	3	1	4	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:43801646C>G	uc002rsw.3	-	11	1910	c.1558G>C	c.(1558-1560)GAC>CAC	p.D520H	THADA_uc002rsx.3_Missense_Mutation_p.D520H|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Missense_Mutation_p.D230H|THADA_uc002rta.2_Missense_Mutation_p.D230H|THADA_uc002rtb.1_Missense_Mutation_p.D520H|THADA_uc002rtc.3_Missense_Mutation_p.D520H|THADA_uc002rtd.2_Missense_Mutation_p.D520H	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	520							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				TGCCACTGGTCAATCCAAGAA	0.383													11	53					0	0	0	0	G	43801646	G	G	43801646	3	3	84	1	0	0	0	0	1	0	0	0	15906	826	29	2	4415	2	THADA	2	43801646	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	19554556	43801646	199397727	42	16610											
LHCGR	3973	broad.mit.edu	37	chr2	48914940	48914940	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttatttgatccagtgaagcCatttttgcagttggaggtgt	8	16	11	6	0	0	2	0	2	0	0	1	3	1	3	2	2	2	2	2	2	2	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:48914940C>A	uc002rwu.3	-	11	2066	c.1996G>T	c.(1996-1998)GGC>TGC	p.G666C	GTF2A1L_uc002rwt.2_Intron	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	666	Cytoplasmic (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	CCAGTGAAGCCATTTTTGCAG	0.428									Familial_Male-Limited_Precocious_Puberty				80	66					7.2426e-40	1.36495e-39	1	0	A	48914940	A	A	48914940	3	1	84	1	0	0	0	0	1	0	0	0	8803	594	21	4	107	4	LHCGR	2	48914940	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	5113294	48914940	194284433	43	16611											
FSHR	2492	broad.mit.edu	37	chr2	49189919	49189919	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaagtatgtaagtggaacCactggtgactctgggagctg	11	9	14	7	0	1	1	0	1	1	0	1	4	1	3	1	3	2	3	1	3	4	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:49189919C>T	uc002rww.2	-	10	2115	c.2041G>A	c.(2041-2043)GGT>AGT	p.G681S	FSHR_uc002rwx.2_Missense_Mutation_p.G619S|FSHR_uc010fbn.2_Missense_Mutation_p.G655S	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	681	Cytoplasmic (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TAAGTGGAACCACTGGTGACT	0.378									Gonadal_Dysgenesis_46_XX				6	109					0	0	0	0	T	49189919	T	T	49189919	3	4	84	1	0	0	0	0	1	0	0	0	6107	594	21	4	50	4	FSHR	2	49189919	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	274979	49189919	194009454	44	16612											
NRXN1	9378	broad.mit.edu	37	chr2	50573944	50573944	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaaactggatgccccccaCgccactcctaggaggccgct	8	5	9	19	2	0	0	0	0	0	0	1	2	1	2	7	3	2	1	7	3	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:50573944C>A	uc010fbp.2	-	1	951	c.144G>T	c.(142-144)GCG>GCT	p.A48A	NRXN1_uc002rxb.3_Intron|NRXN1_uc010fbq.2_Intron|NRXN1_uc002rxe.3_Intron|NRXN1_uc002rxc.1_Intron	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	48					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ATGCCCCCCACGCCACTCCTA	0.507													19	13					5.35356e-11	8.39955e-11	1	0	A	50573944	A	A	50573944	2	1	84	1	0	0	0	0	0	0	0	1	10719	523	19	3		3	NRXN1	2	50573944	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1384025	50573944	192625429	45	16613											
USP34	9736	broad.mit.edu	37	chr2	61566804	61566804	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgttgaattgatgtttaTgaactacaggtcctgaagag	12	14	10	5	0	0	5	0	4	0	1	1	5	1	5	1	1	3	2	1	1	6	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:61566804T>C	uc002sbe.2	-	17	2535	c.2513A>G	c.(2512-2514)CAT>CGT	p.H838R		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	838					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TTGATGTTTATGAACTACAGG	0.318													15	34					0	0	0	0	C	61566804	C	C	61566804	3	2	84	1	0	0	0	0	1	0	0	0	17133	1464	51	5	8383	5	USP34	2	61566804	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	10992860	61566804	181632569	46	16614											
EIF2AK3	9451	broad.mit.edu	37	chr2	88870420	88870420	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctcatatacagtttggtcCctacttgtcctgtgtgtctg	5	16	10	10	0	2	0	1	0	1	0	4	0	4	0	2	2	2	2	2	2	3	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:88870420C>A	uc002stc.3	-	14	3159	c.2957G>T	c.(2956-2958)GGG>GTG	p.G986V		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	986	Cytoplasmic (Potential).|Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						CAGTTTGGTCCCTACTTGTCC	0.473													68	84					2.05175e-36	3.84402e-36	1	0	A	88870420	A	A	88870420	3	1	84	1	0	0	0	0	1	0	0	0	5020	623	22	4	409	4	EIF2AK3	2	88870420	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	27303616	88870420	154328953	47	16615											
SNRNP200	23020	broad.mit.edu	37	chr2	96944433	96944433	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgacaagtggtccgacaaGtgacgatgggagatgcctat	11	9	13	8	2	1	3	0	2	1	1	2	6	2	3	2	2	1	0	2	2	3	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:96944433G>C	uc002svu.2	-	38	5426	c.5340C>G	c.(5338-5340)CAC>CAG	p.H1780Q	SNRNP200_uc002svt.2_Missense_Mutation_p.H390Q|SNRNP200_uc010yuj.1_RNA	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1780						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						GGTCCGACAAGTGACGATGGG	0.577													27	51					0	0	0	0	C	96944433	C	C	96944433	3	2	84	1	0	0	0	0	1	0	0	0	14916	1020	36	4	1102	4	SNRNP200	2	96944433	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	8074013	96944433	146254940	48	16616											
GLI2	2736	broad.mit.edu	37	chr2	121740372	121740372	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaccggggagaagccataTgtgtgtgagcacgagggctg	10	6	16	9	2	0	2	0	1	0	1	0	4	0	2	2	3	2	2	2	3	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:121740372T>C	uc010flp.2	+	10	1629	c.1599T>C	c.(1597-1599)TAT>TAC	p.Y533Y	GLI2_uc002tmq.1_Silent_p.Y205Y|GLI2_uc002tmr.1_Silent_p.Y188Y|GLI2_uc002tmt.3_Silent_p.Y205Y|GLI2_uc002tmu.3_Silent_p.Y188Y|GLI2_uc002tmw.1_Silent_p.Y516Y	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	533	C2H2-type 4.				axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				AGAAGCCATATGTGTGTGAGC	0.617													4	39					0	0	0	0	C	121740372	C	C	121740372	2	2	84	1	0	0	0	0	0	0	0	1	6475	1471	51	5		5	GLI2	2	121740372	Silent	SNP	T	TCGA-CN-6992-01A-11D-1912-08	24795939	121740372	121459001	49	16617											
LRP1B	53353	broad.mit.edu	37	chr2	141201897	141201897	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agagtattttgaggtgacttAcgacagtctctttcatcttc	9	16	8	8	1	3	3	1	2	2	1	5	4	3	3	0	1	1	1	0	1	2	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:141201897A>C	uc002tvj.1	-	65	11266	c.10294_splice	c.e65+1	p.P3432_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAGGTGACTTACGACAGTCTC	0.328										TSP Lung(27;0.18)			60	27					0	0	0	0	C	141201897	C	C	141201897	5	2	84	1	0	0	0	0	0	0	1	0	9005	405	14	5	3611	5	LRP1B	2	141201897	Splice_Site	SNP	A	TCGA-CN-6992-01A-11D-1912-08	19461525	141201897	101997476	50	16618											
LRP1B	53353	broad.mit.edu	37	chr2	141232793	141232793	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacgattaacataatctattGttagtgccataggtctagaa	14	14	7	6	1	2	1	0	0	2	1	2	2	2	1	1	1	3	1	1	1	8	8			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:141232793G>T	uc002tvj.1	-	60	10511	c.9539C>A	c.(9538-9540)ACA>AAA	p.T3180K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3180	Extracellular (Potential).|LDL-receptor class B 30.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATAATCTATTGTTAGTGCCAT	0.408										TSP Lung(27;0.18)			72	29					1.59245e-42	3.01902e-42	1	0	T	141232793	T	T	141232793	3	4	84	1	0	0	0	0	1	0	0	0	9005	1377	48	4	4388	4	LRP1B	2	141232793	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	30896	141232793	101966580	51	16619											
SCN1A	6323	broad.mit.edu	37	chr2	166898884	166898884	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctagaaagtccatggaaacGtggaaagaacttgaccttct	14	10	9	8	1	2	3	0	1	2	2	3	5	3	5	2	2	2	0	2	2	5	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:166898884G>T	uc010zcz.1	-	12	2079	c.2061C>A	c.(2059-2061)CAC>CAA	p.H687Q	SCN1A_uc002udo.3_Missense_Mutation_p.H567Q|SCN1A_uc010fpk.2_Missense_Mutation_p.H539Q	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	698						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCATGGAAACGTGGAAAGAAC	0.358													46	22					1.7489e-18	3.00284e-18	1	0	T	166898884	T	T	166898884	3	4	84	1	0	0	0	0	1	0	0	0	13979	1136	40	3	3995	3	SCN1A	2	166898884	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	25666091	166898884	76300489	52	16620											
XIRP2	129446	broad.mit.edu	37	chr2	168107605	168107605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaactcgtggtagggactctCcacctacaatcacaatacca	14	8	6	13	1	2	0	1	0	1	0	4	1	2	1	3	2	3	1	3	2	6	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:168107605C>T	uc002udx.2	+	8	9721	c.9703C>T	c.(9703-9705)CCA>TCA	p.P3235S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.P3060S|XIRP2_uc010fpq.2_Missense_Mutation_p.P3013S|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3060					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TAGGGACTCTCCACCTACAAT	0.438													35	16					0	0	0	0	T	168107605	T	T	168107605	3	4	84	1	0	0	0	0	1	0	0	0	17498	855	30	2	9733	2	XIRP2	2	168107605	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1208721	168107605	75091768	53	16621											
TTN	7273	broad.mit.edu	37	chr2	179498188	179498188	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgtgccacagtcacacaCatattcgcctttatctttaa	10	14	5	12	1	3	0	1	0	2	0	4	0	3	0	2	0	1	0	2	0	3	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:179498188C>T	uc010zfg.1	-	181	35418	c.35194G>A	c.(35194-35196)GTG>ATG	p.V11732M	TTN_uc010zfh.1_Missense_Mutation_p.V5427M|TTN_uc010zfi.1_Missense_Mutation_p.V5360M|TTN_uc010zfj.1_Missense_Mutation_p.V5235M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12659							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGTCACACACATATTCGCCT	0.413													52	22					0	0	0	0	T	179498188	T	T	179498188	3	4	84	1	0	0	0	0	1	0	0	0	16803	478	17	4	65319	4	TTN	2	179498188	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	11390583	179498188	63701185	54	16622											
ZNF804A	91752	broad.mit.edu	37	chr2	185803233	185803233	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagcaagcattattgatccCactagaaaaccatgacaaat	18	8	6	9	0	0	4	0	2	0	2	1	4	1	4	2	0	3	2	2	0	6	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:185803233C>T	uc002uph.2	+	4	3704	c.3110C>T	c.(3109-3111)CCA>CTA	p.P1037L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1037						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TTATTGATCCCACTAGAAAAC	0.413													69	23					0	0	0	0	T	185803233	T	T	185803233	3	4	84	1	0	0	0	0	1	0	0	0	18237	594	21	4	3124	4	ZNF804A	2	185803233	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	6305045	185803233	57396140	55	16623											
COL5A2	1290	broad.mit.edu	37	chr2	189925481	189925481	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacctggttttccaccttctCcaggaggccctggaggacca	7	9	10	15	0	1	0	0	0	1	0	3	3	2	3	6	5	0	1	6	5	0	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:189925481C>A	uc002uqk.2	-	31	2335	c.2060G>T	c.(2059-2061)GGA>GTA	p.G687V	COL5A2_uc010frx.2_Missense_Mutation_p.G263V	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	687					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TCCACCTTCTCCAGGAGGCCC	0.338													29	16					2.2171e-23	3.97829e-23	1	0	A	189925481	A	A	189925481	3	1	84	1	0	0	0	0	1	0	0	0	3712	855	30	2	2535	2	COL5A2	2	189925481	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	4122248	189925481	53273892	56	16624											
COQ10B	80219	broad.mit.edu	37	chr2	198334873	198334873	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcttcctggctacccaaGaacttgtaccttggattttt	8	15	8	10	0	1	1	0	0	1	1	2	2	2	2	3	3	3	2	3	3	4	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:198334873G>T	uc002uuh.1	+	4	581	c.527G>T	c.(526-528)AGA>ATA	p.R176I	COQ10B_uc010fsl.1_Missense_Mutation_p.R148I	NM_025147	NP_079423	Q9H8M1	CQ10B_HUMAN	coenzyme Q10 homolog B precursor	176						mitochondrial inner membrane					0			Epithelial(96;0.231)|OV - Ovarian serous cystadenocarcinoma(117;0.246)			GGCTACCCAAGAACTTGTACC	0.358													8	38					5.4927e-09	8.27152e-09	1	0	T	198334873	T	T	198334873	3	4	84	1	0	0	0	0	1	0	0	0	3759	942	33	2	541	2	COQ10B	2	198334873	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	8409392	198334873	44864500	57	16625											
SPAG16	79582	broad.mit.edu	37	chr2	215275038	215275038	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagttcgaacgtggtcttGaccgtcagcacatcccgctg	8	9	10	14	4	2	1	1	1	1	0	4	2	3	1	2	1	2	3	2	1	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:215275038G>C	uc002veq.2	+	16	1987	c.1895G>C	c.(1894-1896)TGA>TCA	p.*632S	SPAG16_uc002ver.2_Nonstop_Mutation_p.*578S|SPAG16_uc010zjk.1_Nonstop_Mutation_p.*538S|VWC2L_uc002vet.2_5'Flank|VWC2L_uc010zjl.1_5'Flank	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	632					cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		ACGTGGTCTTGACCGTCAGCA	0.527													16	68					0	0	0	0	C	215275038	C	C	215275038	4	2	84	1	0	0	0	0	0	0	0	0	15044	1285	45	2	1973	2	SPAG16	2	215275038	Nonstop_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	16940165	215275038	27924335	58	16626											
COL4A3	1285	broad.mit.edu	37	chr2	228173623	228173623	+	Frame_Shift_Del	DEL	G	-	-																															atgtttcattaggaactcttGgcagctgcctgcagcgattt																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:228173623delG	uc002vom.1	+	49	4633	c.4471delG	c.(4471-4473)GGCfs	p.G1491fs	COL4A3_uc002von.1_Frame_Shift_Del_p.G1491fs|COL4A3_uc002voo.1_Intron|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron|COL4A3_uc010fxf.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1491	Required for the anti-angiogenic activity of tumstatin.|Collagen IV NC1.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AGGAACTCTTGGCAGCTGCCT	0.368													---	---	---								-	228173623	-	-	228173623	7	5	84	1	0	1	0	1	0	0	0	0	3706	1348	47	0	4665	0	COL4A3	2	228173623	Frame_Shift_Del	DEL	G	TCGA-CN-6992-01A-11D-1912-08	12898585	228173623	15025750	59	16627											
SPHKAP	80309	broad.mit.edu	37	chr2	228973575	228973575	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagttttcagacttgtcttcTacaaaaccaatttggcaggg	11	13	8	9	0	3	1	1	0	2	1	3	1	3	1	1	2	2	2	1	2	4	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:228973575T>A	uc002vpq.2	-	3	266	c.219A>T	c.(217-219)GTA>GTT	p.V73V	SPHKAP_uc002vpp.2_Silent_p.V73V|SPHKAP_uc010zlx.1_Silent_p.V73V	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	73						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ACTTGTCTTCTACAAAACCAA	0.468													69	37					0	0	0	0	A	228973575	A	A	228973575	2	1	84	1	0	0	0	0	0	0	0	1	15114	1509	53	5		5	SPHKAP	2	228973575	Silent	SNP	T	TCGA-CN-6992-01A-11D-1912-08	799952	228973575	14225798	60	16628											
COL6A3	1293	broad.mit.edu	37	chr2	238242092	238242092	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctaatagtttcacaactcaCctgtttcagtgagagccaat	12	12	6	11	0	3	1	3	1	0	1	3	2	3	1	3	0	2	2	3	0	4	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:238242092C>T	uc002vwl.2	-	42	9613	c.9328_splice	c.e42+1	p.D3110_splice	COL6A3_uc002vwo.2_Splice_Site_p.D2904_splice|COL6A3_uc010znj.1_Splice_Site_p.D2503_splice|COL6A3_uc002vwj.2_Splice_Site_p.D491_splice	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor						axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TCACAACTCACCTGTTTCAGT	0.448													45	16					0	0	0	0	T	238242092	T	T	238242092	5	4	84	1	0	0	0	0	0	0	1	0	3716	521	18	4	216	4	COL6A3	2	238242092	Splice_Site	SNP	C	TCGA-CN-6992-01A-11D-1912-08	9268517	238242092	4957281	61	16629											
PASK	23178	broad.mit.edu	37	chr2	242079332	242079332	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccaccgcagcgtggccgtCggcctccatgtgctcctcgc	4	7	11	19	5	0	0	0	0	0	0	4	0	2	0	6	2	2	2	6	2	0	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr2:242079332C>T	uc002wao.1	-	4	660	c.568G>A	c.(568-570)GAC>AAC	p.D190N	PASK_uc010zol.1_Intron|PASK_uc010zom.1_Missense_Mutation_p.D190N|PASK_uc010fzl.1_Missense_Mutation_p.D190N|PASK_uc010zon.1_Intron|PASK_uc002waq.2_Missense_Mutation_p.D190N	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	190	PAS 1.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GCGTGGCCGTCGGCCTCCATG	0.607													5	44					0	0	0	0	T	242079332	T	T	242079332	3	4	84	1	0	0	0	0	1	0	0	0	11526	884	31	1	3463	1	PASK	2	242079332	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3837240	242079332	1120041	62	16630											
TGM4	7047	broad.mit.edu	37	chr3	44951648	44951648	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttctgagagggagcacaGacgacctgtaaaagagaact	15	6	12	8	1	1	3	0	1	1	3	1	7	1	4	1	1	2	3	1	1	3	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:44951648G>A	uc003coc.3	+	11	1467	c.1394G>A	c.(1393-1395)AGA>AAA	p.R465K		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	465					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	AGGGAGCACAGACGACCTGTA	0.478													22	30					0	0	0	0	A	44951648	A	A	44951648	3	1	84	1	0	0	0	0	1	0	0	0	15898	942	33	2	1436	2	TGM4	3	44951648	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08		44951648	153070782	63	16631											
TGM4	7047	broad.mit.edu	37	chr3	44952515	44952515	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctggctatattagatgatGagccagttatcagaggtttc	10	13	11	7	0	1	4	1	2	0	2	2	4	1	4	2	2	1	3	2	2	4	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:44952515G>C	uc003coc.3	+	12	1745	c.1672G>C	c.(1672-1674)GAG>CAG	p.E558Q		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	558					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	ATTAGATGATGAGCCAGTTAT	0.458													21	45					0	0	0	0	C	44952515	C	C	44952515	3	2	84	1	0	0	0	0	1	0	0	0	15898	1291	45	2	1718	2	TGM4	3	44952515	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	867	44952515	153069915	64	16632											
SACM1L	22908	broad.mit.edu	37	chr3	45776775	45776775	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtggcaaaccaggaaggCgtgttccgaagcaattgcat	11	8	14	8	2	0	0	0	0	0	0	1	2	1	1	2	4	3	4	2	4	4	2	rs138504596		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:45776775C>T	uc003cos.2	+	14	1353	c.1149C>T	c.(1147-1149)GGC>GGT	p.G383G	SACM1L_uc011bag.1_Silent_p.G280G|SACM1L_uc011bah.1_Silent_p.G317G|SACM1L_uc003cot.2_Silent_p.G26G	NM_014016	NP_054735	Q9NTJ5	SAC1_HUMAN	suppressor of actin 1	383	SAC.					Golgi apparatus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		ACCAGGAAGGCGTGTTCCGAA	0.438													15	42					0	0	0	0	T	45776775	T	T	45776775	2	4	84	1	0	0	0	0	0	0	0	1	13868	755	27	1		1	SACM1L	3	45776775	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	824260	45776775	152245655	65	16633											
DHX30	22907	broad.mit.edu	37	chr3	47887994	47887994	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctggagcgctatgtgaccGagggccgaggtgcccgctgc	5	7	17	12	4	0	1	0	1	0	0	0	4	0	2	3	3	4	3	3	3	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:47887994G>A	uc003cru.2	+	11	1858	c.1432G>A	c.(1432-1434)GAG>AAG	p.E478K	DHX30_uc003crt.2_Missense_Mutation_p.E439K	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	478	Helicase ATP-binding.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CTATGTGACCGAGGGCCGAGG	0.642													19	45					0	0	0	0	A	47887994	A	A	47887994	3	1	84	1	0	0	0	0	1	0	0	0	4526	1059	37	1	1477	1	DHX30	3	47887994	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2111219	47887994	150134436	66	16634											
TWF2	11344	broad.mit.edu	37	chr3	52263103	52263103	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatgaggcgcttatggccccGcttgccccctgggcccttgg	3	9	14	15	2	0	1	0	1	0	0	0	2	0	1	5	4	1	2	5	4	1	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:52263103G>A	uc003ddd.2	-	9	1148	c.997C>T	c.(997-999)CGG>TGG	p.R333W	TLR9_uc003dda.1_5'Flank|TLR9_uc003ddb.2_Intron|TLR9_uc003ddc.1_Intron|TWF2_uc010hmc.2_3'UTR	NM_007284	NP_009215	Q6IBS0	TWF2_HUMAN	twinfilin-like protein	333						cytoskeleton|perinuclear region of cytoplasm	actin binding|ATP binding			stomach(1)|ovary(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;2.43e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TTATGGCCCCGCTTGCCCCCT	0.672													9	43					0	0	0	0	A	52263103	A	A	52263103	3	1	84	1	0	0	0	0	1	0	0	0	16850	1086	38	1	56	1	TWF2	3	52263103	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	4375109	52263103	145759327	67	16635											
TKT	7086	broad.mit.edu	37	chr3	53260829	53260829	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttggtggcacgagcgctgtCgagaatgagttttctgtcca	7	12	13	9	3	1	2	0	1	1	1	3	4	2	2	1	2	1	3	1	2	1	3	rs148472107		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:53260829C>T	uc003dgo.2	-	13	1749	c.1639G>A	c.(1639-1641)GAC>AAC	p.D547N	TKT_uc003dgp.2_Missense_Mutation_p.D179N|TKT_uc011beo.1_Missense_Mutation_p.D500N|TKT_uc003dgq.2_Missense_Mutation_p.D547N|TKT_uc011beq.1_Missense_Mutation_p.D555N|TKT_uc011ber.1_Missense_Mutation_p.D349N|TKT_uc011bep.1_Missense_Mutation_p.D464N	NM_001135055	NP_001128527	P29401	TKT_HUMAN	transketolase isoform 1	547					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			ovary(2)	2		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	CGAGCGCTGTCGAGAATGAGT	0.602													7	48					0	0	0	0	T	53260829	T	T	53260829	3	4	84	1	0	0	0	0	1	0	0	0	16000	884	31	1	240	1	TKT	3	53260829	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	997726	53260829	144761601	68	16636											
ROBO2	6092	broad.mit.edu	37	chr3	77089985	77089985	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctctgtggatttttatatGttcgggttgatggtaagtta	7	19	12	3	1	1	1	0	1	1	0	2	2	1	2	0	3	1	5	0	3	4	8			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:77089985G>T	uc003dpy.3	+	1	692	c.49G>T	c.(49-51)GTT>TTT	p.V17F	ROBO2_uc003dpz.2_Missense_Mutation_p.V17F|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.V17F	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	17					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ATTTTTATATGTTCGGGTTGA	0.383													37	32					1.15505e-17	1.95682e-17	1	0	T	77089985	T	T	77089985	3	4	84	1	0	0	0	0	1	0	0	0	13579	1377	48	4	51	4	ROBO2	3	77089985	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	23829156	77089985	120932445	69	16637											
ZBED2	79413	broad.mit.edu	37	chr3	111312889	111312889	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atattcccatgcctcagagaAccgggtgcccttgttgtggg	7	11	12	11	1	1	1	1	0	0	1	2	2	2	1	4	2	3	1	4	2	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:111312889A>T	uc003dxy.2	-	2	1045	c.160T>A	c.(160-162)TTC>ATC	p.F54I	CD96_uc003dxv.2_Intron|CD96_uc003dxw.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_024508	NP_078784	Q9BTP6	ZBED2_HUMAN	zinc finger, BED domain containing 2	54	BED-type.						DNA binding|metal ion binding			skin(1)	1						GCCTCAGAGAACCGGGTGCCC	0.572													25	44					0	0	0	0	T	111312889	T	T	111312889	3	4	84	1	0	0	0	0	1	0	0	0	17586	43	2	5	500	5	ZBED2	3	111312889	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	34222904	111312889	86709541	70	16638											
ZBTB20	26137	broad.mit.edu	37	chr3	114069375	114069375	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcttggggccactgcccGcgggctgggtagtgaagagg	7	6	19	9	2	0	2	0	1	0	1	0	2	0	2	2	6	1	3	2	6	3	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:114069375G>A	uc003ebi.2	-	4	1730	c.1550C>T	c.(1549-1551)GCG>GTG	p.A517V	ZBTB20_uc003ebj.2_Missense_Mutation_p.A444V|ZBTB20_uc010hqp.2_Missense_Mutation_p.A444V|ZBTB20_uc003ebk.2_Missense_Mutation_p.A444V|ZBTB20_uc003ebl.2_Missense_Mutation_p.A444V|ZBTB20_uc003ebm.2_Missense_Mutation_p.A444V|ZBTB20_uc003ebn.2_Missense_Mutation_p.A444V|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	517				A -> V (in Ref. 1; AAG28340).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GCCACTGCCCGCGGGCTGGGT	0.622													12	68					0	0	0	0	A	114069375	A	A	114069375	3	1	84	1	0	0	0	0	1	0	0	0	17596	1087	38	1	683	1	ZBTB20	3	114069375	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2756486	114069375	83953055	71	16639											
CHCHD6	84303	broad.mit.edu	37	chr3	126633572	126633572	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaattccatgaggcagcctCaaagatggagagcacaataa	16	6	10	9	0	1	3	1	1	0	2	2	4	2	3	2	2	2	3	2	2	4	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:126633572C>G	uc003ejf.1	+	6	583	c.545C>G	c.(544-546)TCA>TGA	p.S182*	CHCHD6_uc010hsj.1_Nonsense_Mutation_p.S183*	NM_032343	NP_115719	Q9BRQ6	CHCH6_HUMAN	coiled-coil-helix-coiled-coil-helix domain	182											0						GAGGCAGCCTCAAAGATGGAG	0.388													33	12					0	0	0	0	G	126633572	G	G	126633572	4	3	84	1	0	0	0	0	0	1	0	0	3335	838	29	2	567	2	CHCHD6	3	126633572	Nonsense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	12564197	126633572	71388858	72	16640											
MCM2	4171	broad.mit.edu	37	chr3	127338055	127338055	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccaaggagagggtccacccGaagctcaaccagatggacca	13	3	12	13	1	1	2	1	0	0	2	2	5	2	3	5	3	2	1	5	3	3	0	rs144817363		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:127338055G>A	uc003ejp.2	+	13	2256	c.2199G>A	c.(2197-2199)CCG>CCA	p.P733P	MCM2_uc011bkm.1_Silent_p.P603P|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Silent_p.P686P	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	733					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						GGGTCCACCCGAAGCTCAACC	0.597													14	48					0	0	0	0	A	127338055	A	A	127338055	2	1	84	1	0	0	0	0	0	0	0	1	9439	1045	37	1		1	MCM2	3	127338055	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	704483	127338055	70684375	73	16641											
BFSP2	8419	broad.mit.edu	37	chr3	133191346	133191346	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgcgcgcatctgctggcccGcaagtgccagctgcagaagg	7	5	15	14	4	1	1	0	0	1	1	1	1	1	1	2	2	4	5	2	2	2	0	rs141155612		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:133191346G>T	uc003epn.1	+	6	1319	c.1181G>T	c.(1180-1182)CGC>CTC	p.R394L		NM_003571	NP_003562	Q13515	BFSP2_HUMAN	phakinin	394	Rod.|Potential.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens				0						CTGCTGGCCCGCAAGTGCCAG	0.662													23	9					5.35356e-11	8.39955e-11	1	0	T	133191346	T	T	133191346	3	4	84	1	0	0	0	0	1	0	0	0	1419	1087	38	3	1203	3	BFSP2	3	133191346	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	5853291	133191346	64831084	74	16642											
GPR171	29909	broad.mit.edu	37	chr3	150916254	150916254	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttaatttttctttctgagccTtggtctctttaggtgaggca	6	19	9	7	0	3	2	0	2	3	0	4	2	3	2	1	3	1	1	1	3	2	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:150916254T>C	uc003eyq.3	-	3	1160	c.920A>G	c.(919-921)AAG>AGG	p.K307R	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_013308	NP_037440	O14626	GP171_HUMAN	G protein-coupled receptor 171	307	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTTCTGAGCCTTGGTCTCTTT	0.398													4	119					0	0	0	0	C	150916254	C	C	150916254	3	2	84	1	0	0	0	0	1	0	0	0	6706	1609	56	5	43	5	GPR171	3	150916254	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	17724908	150916254	47106176	75	16643											
MME	4311	broad.mit.edu	37	chr3	154886357	154886357	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agtaactttaaggagcaatcCcagtgcatggtgtatcagta	13	11	10	7	0	1	0	1	0	0	0	2	1	2	1	1	2	3	5	1	2	5	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:154886357C>A	uc010hvr.1	+	19	2068	c.1857C>A	c.(1855-1857)TCC>TCA	p.S619S	MME_uc003fab.1_Silent_p.S619S|MME_uc003fac.1_Silent_p.S619S|MME_uc003fad.1_Silent_p.S619S|MME_uc003fae.1_Silent_p.S619S	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	619	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	AGGAGCAATCCCAGTGCATGG	0.393													36	74					2.86225e-05	4.07887e-05	1	0	A	154886357	A	A	154886357	2	1	84	1	0	0	0	0	0	0	0	1	9698	610	22	4		4	MME	3	154886357	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3970103	154886357	43136073	76	16644											
KPNA4	3840	broad.mit.edu	37	chr3	160219947	160219947	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atgaattgaaaccaaatgttCcgccttgaattgcctctgga	12	12	8	9	1	1	3	0	3	1	0	2	4	2	4	4	1	2	1	4	1	4	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:160219947C>G	uc003fdn.2	-	17	1817	c.1511G>C	c.(1510-1512)GGA>GCA	p.G504A		NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4	504					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			ACCAAATGTTCCGCCTTGAAT	0.348													15	205					0	0	0	0	G	160219947	G	G	160219947	3	3	84	1	0	0	0	0	1	0	0	0	8471	855	30	2	58	2	KPNA4	3	160219947	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	5333590	160219947	37802483	77	16645											
SLITRK3	22865	broad.mit.edu	37	chr3	164906545	164906545	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaggtccacaccttcctgccGcttgcttctgaagggcagct	7	10	10	14	1	1	1	0	1	1	0	3	1	3	1	4	2	3	4	4	2	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:164906545G>T	uc003fej.3	-	2	2518	c.2074C>A	c.(2074-2076)CGG>AGG	p.R692R	SLITRK3_uc003fek.2_Silent_p.R692R	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	692	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CCTTCCTGCCGCTTGCTTCTG	0.448										HNSCC(40;0.11)			27	47					6.12954e-19	1.06101e-18	1	0	T	164906545	T	T	164906545	2	4	84	1	0	0	0	0	0	0	0	1	14808	1086	38	3		3	SLITRK3	3	164906545	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	4686598	164906545	33115885	78	16646											
TNIK	23043	broad.mit.edu	37	chr3	170819397	170819397	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttcaatccggagttctcttAgttctttggctaatgccgtc	6	16	8	11	2	3	0	1	0	2	0	6	1	4	1	2	2	1	3	2	2	3	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:170819397A>G	uc003fhh.2	-	22	2777	c.2432T>C	c.(2431-2433)CTA>CCA	p.L811P	TNIK_uc003fhi.2_Missense_Mutation_p.L756P|TNIK_uc003fhj.2_Missense_Mutation_p.L782P|TNIK_uc003fhk.2_Missense_Mutation_p.L803P|TNIK_uc003fhl.2_Missense_Mutation_p.L727P|TNIK_uc003fhm.2_Missense_Mutation_p.L748P|TNIK_uc003fhn.2_Missense_Mutation_p.L774P|TNIK_uc003fho.2_Missense_Mutation_p.L719P|TNIK_uc003fhg.2_5'UTR	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	811	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GAGTTCTCTTAGTTCTTTGGC	0.448													51	181					0	0	0	0	G	170819397	G	G	170819397	3	3	84	1	0	0	0	0	1	0	0	0	16379	420	15	5	1698	5	TNIK	3	170819397	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	5912852	170819397	27203033	79	16647											
ATP13A5	344905	broad.mit.edu	37	chr3	192994612	192994612	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctccacgatgttatggttGggatcaactgttgaaaaaca	12	11	9	9	1	1	1	1	1	0	0	2	3	2	2	2	2	2	3	2	2	4	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:192994612G>T	uc011bsq.1	-	29	3323	c.3323C>A	c.(3322-3324)CCA>CAA	p.P1108Q		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	1108					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TGTTATGGTTGGGATCAACTG	0.239													16	44					7.07596e-05	0.000100164	1	0	T	192994612	T	T	192994612	3	4	84	1	0	0	0	0	1	0	0	0	1129	1348	47	4	339	4	ATP13A5	3	192994612	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	22175215	192994612	5027818	80	16648											
MUC4	4585	broad.mit.edu	37	chr3	195489041	195489041	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagagcgcgatcaccgagAcggtggcccagccgtcgaag	9	4	16	12	6	1	2	1	0	0	2	2	6	1	2	3	3	2	0	3	3	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr3:195489041A>T	uc011bto.1	-	15	14505	c.14045T>A	c.(14044-14046)GTC>GAC	p.V4682D	MUC4_uc003fuz.2_Missense_Mutation_p.V408D|MUC4_uc003fva.2_Missense_Mutation_p.V290D|MUC4_uc003fvb.2_Missense_Mutation_p.V326D|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Missense_Mutation_p.V326D|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Missense_Mutation_p.V290D|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Missense_Mutation_p.V374D|MUC4_uc011bti.1_Missense_Mutation_p.V374D|MUC4_uc011btj.1_Missense_Mutation_p.V551D|MUC4_uc011btk.1_Missense_Mutation_p.V290D|MUC4_uc011btl.1_Missense_Mutation_p.V319D|MUC4_uc011btm.1_Missense_Mutation_p.V499D|MUC4_uc011btn.1_Missense_Mutation_p.V290D|MUC4_uc003fvo.2_Missense_Mutation_p.V574D|MUC4_uc003fvp.2_Missense_Mutation_p.V523D	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1567	VWFD.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GATCACCGAGACGGTGGCCCA	0.697													9	16					0	0	0	0	T	195489041	T	T	195489041	3	4	84	1	0	0	0	0	1	0	0	0	10031	275	10	5	1857	5	MUC4	3	195489041	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	2494429	195489041	2533389	81	16649											
FAM193A	8603	broad.mit.edu	37	chr4	2661595	2661595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cacgtgtggtatcatggaccCccccgtcactgatgacatcc	8	9	9	15	2	2	2	2	2	0	0	3	3	3	3	4	2	0	1	4	2	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:2661595C>T	uc010icl.2	+	8	1037	c.686C>T	c.(685-687)CCC>CTC	p.P229L	FAM193A_uc010ick.2_Missense_Mutation_p.P429L|FAM193A_uc003gfd.2_Missense_Mutation_p.P229L|FAM193A_uc011bvm.1_Missense_Mutation_p.P253L|FAM193A_uc011bvn.1_Missense_Mutation_p.P229L|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.P83L	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	229										ovary(3)	3						ATCATGGACCCCCCCGTCACT	0.522													31	35					0	0	0	0	T	2661595	T	T	2661595	3	4	84	1	0	0	0	0	1	0	0	0	5552	623	22	4	708	4	FAM193A	4	2661595	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08		2661595	188492681	82	16650											
KLHL5	51088	broad.mit.edu	37	chr4	39122661	39122661	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcctaggaagagctggagCttgtgttgtgactgtaaaat	10	12	14	5	0	0	2	0	1	0	1	0	4	0	4	1	2	3	4	1	2	4	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:39122661C>G	uc003gts.2	+	11	2318	c.2243C>G	c.(2242-2244)GCT>GGT	p.A748G	KLHL5_uc003gtp.2_Missense_Mutation_p.A702G|KLHL5_uc003gtq.2_Missense_Mutation_p.A561G|KLHL5_uc003gtt.2_Missense_Mutation_p.A687G	NM_015990	NP_057074	Q96PQ7	KLHL5_HUMAN	kelch-like 5 isoform 1	748	Kelch 6.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1						AGAGCTGGAGCTTGTGTTGTG	0.363													8	33					0	0	0	0	G	39122661	G	G	39122661	3	3	84	1	0	0	0	0	1	0	0	0	8431	797	28	4	2285	4	KLHL5	4	39122661	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	36461066	39122661	152031615	83	16651											
DCAF4L1	285429	broad.mit.edu	37	chr4	41984019	41984019	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggatccctcctctttggcGagcgaccgatttaacttcat	7	14	8	12	3	2	0	1	0	1	0	4	4	4	1	3	2	2	0	3	2	1	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:41984019G>T	uc003gwk.2	+	1	307	c.210G>T	c.(208-210)GCG>GCT	p.A70A		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	70										skin(1)	1						CCTCTTTGGCGAGCGACCGAT	0.537													21	12					4.35082e-09	6.56746e-09	1	0	T	41984019	T	T	41984019	2	4	84	1	0	0	0	0	0	0	0	1	4288	1045	37	3		3	DCAF4L1	4	41984019	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2861358	41984019	149170257	84	16652											
NPFFR2	10886	broad.mit.edu	37	chr4	73012771	73012771	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcattattatgatcatctggGtcctagccatcaccattatg	10	15	6	10	0	4	1	3	1	1	0	5	1	5	1	3	1	1	0	3	1	4	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:73012771G>C	uc003hgg.2	+	4	909	c.811G>C	c.(811-813)GTC>CTC	p.V271L	NPFFR2_uc010iig.1_Missense_Mutation_p.V53L|NPFFR2_uc003hgi.2_Missense_Mutation_p.V172L|NPFFR2_uc003hgh.2_Missense_Mutation_p.V169L|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	271	Helical; Name=4; (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GATCATCTGGGTCCTAGCCAT	0.388													58	160					0	0	0	0	C	73012771	C	C	73012771	3	2	84	1	0	0	0	0	1	0	0	0	10632	1261	44	4	831	4	NPFFR2	4	73012771	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	31028752	73012771	118141505	85	16653											
WDFY3	23001	broad.mit.edu	37	chr4	85661382	85661382	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcagtgggccagacagctaAtgaattcttggtcatggttc	10	11	12	8	0	2	2	1	1	1	1	3	2	2	2	1	3	2	3	1	3	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:85661382A>T	uc003hpd.2	-	39	6830	c.6422T>A	c.(6421-6423)ATT>AAT	p.I2141N		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2141						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CAGACAGCTAATGAATTCTTG	0.423													31	67					0	0	0	0	T	85661382	T	T	85661382	3	4	84	1	0	0	0	0	1	0	0	0	17338	101	4	5	4278	5	WDFY3	4	85661382	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	12648611	85661382	105492894	86	16654											
PTPN13	5783	broad.mit.edu	37	chr4	87610317	87610317	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctacgtgaaacacttggtaAaactggttctgggaaatctt	12	12	9	8	1	2	1	0	1	2	0	2	2	2	2	1	3	3	2	1	3	5	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:87610317A>G	uc003hpz.2	+	5	1000	c.520A>G	c.(520-522)AAA>GAA	p.K174E	PTPN13_uc003hpy.2_Missense_Mutation_p.K174E|PTPN13_uc003hqa.2_Missense_Mutation_p.K174E|PTPN13_uc003hqb.2_Missense_Mutation_p.K174E	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	174	KIND.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		ACACTTGGTAAAACTGGTTCT	0.373													52	117					0	0	0	0	G	87610317	G	G	87610317	3	3	84	1	0	0	0	0	1	0	0	0	12845	15	1	5	534	5	PTPN13	4	87610317	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	1948935	87610317	103543959	87	16655											
ADH6	130	broad.mit.edu	37	chr4	100131356	100131356	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagatttcctttatcactgtGtattcacagaaggtgctggt	9	15	10	7	0	2	2	2	0	0	2	3	3	3	2	1	2	1	2	1	2	3	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:100131356G>T	uc003hup.3	-	5	544	c.450C>A	c.(448-450)TAC>TAA	p.Y150*	uc003hum.1_Intron|ADH6_uc003huo.2_Nonsense_Mutation_p.Y150*|ADH6_uc011cef.1_Intron|ADH6_uc010ile.2_Nonsense_Mutation_p.Y150*	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	150					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	TTATCACTGTGTATTCACAGA	0.433													37	61					8.73648e-17	1.45304e-16	1	0	T	100131356	T	T	100131356	4	4	84	1	0	0	0	0	0	1	0	0	312	1372	48	4	701	4	ADH6	4	100131356	Nonsense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	12521039	100131356	91022920	88	16656											
C4orf21	55345	broad.mit.edu	37	chr4	113461126	113461127	+	Frame_Shift_Ins	INS	-	T	T																															agtcaatgcaacattcattcINSttttttctgaatcaatgaat																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:113461126_113461127insT	uc003iau.2	-	27	6275_6276	c.6064_6065insA	c.(6064-6066)AGAfs	p.R2022fs	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Frame_Shift_Ins_p.R480fs	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	844						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		AACATTCATTCTTTTTTCTGAA	0.406													---	---	---								T	113461127	T	T	113461126	7	5	84	1	0	1	1	0	0	0	0	0	2264	913	32	0	257	0	C4orf21	4	113461126	Frame_Shift_Ins	INS	-	TCGA-CN-6992-01A-11D-1912-08	13329770	113461126	77693150	89	16657											
NDST4	64579	broad.mit.edu	37	chr4	115767118	115767118	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttcaaacagaaagtcacttGtagtattggatggtgtaggg	12	13	12	4	0	2	1	2	0	0	1	2	2	2	2	0	3	1	3	0	3	5	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:115767118G>T	uc003ibu.2	-	10	2655	c.1976C>A	c.(1975-1977)ACA>AAA	p.T659K	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	659	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AAAGTCACTTGTAGTATTGGA	0.388													24	42					1.1804e-14	1.92305e-14	1	0	T	115767118	T	T	115767118	3	4	84	1	0	0	0	0	1	0	0	0	10312	1377	48	4	662	4	NDST4	4	115767118	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2305992	115767118	75387158	90	16658											
CCNA2	890	broad.mit.edu	37	chr4	122743676	122743678	+	In_Frame_Del	DEL	CTT	-	-																															attttttgagattcagctggCttcttctgagcttctttttc																								rs140275604	by1000genomes	TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:122743676_122743678delCTT	uc003iec.3	-	2	642_644	c.337_339delAAG	c.(337-339)AAGdel	p.K113del		NM_001237	NP_001228	P20248	CCNA2_HUMAN	cyclin A	113					cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			ovary(1)	1						ATTCAGCTGGCTTCTTCTGAGCT	0.433													---	---	---								-	122743678	-	-	122743676	7	5	84	1	0	1	0	1	0	0	0	0	2925	796	28	0	987	0	CCNA2	4	122743676	In_Frame_Del	DEL	CTT	TCGA-CN-6992-01A-11D-1912-08	6976558	122743676	68410600	91	16659											
PCDH10	57575	broad.mit.edu	37	chr4	134072572	134072572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccccctggaccgagaggcggGggactcctacaccctgactg	7	5	13	16	2	0	2	0	1	0	1	1	5	1	4	5	4	1	0	5	4	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:134072572G>A	uc003iha.2	+	1	2103	c.1277G>A	c.(1276-1278)GGG>GAG	p.G426E	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.G426E	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	426	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CGAGAGGCGGGGGACTCCTAC	0.587													95	47					0	0	0	0	A	134072572	A	A	134072572	3	1	84	1	0	0	0	0	1	0	0	0	11561	1232	43	4	1279	4	PCDH10	4	134072572	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	11328896	134072572	57081704	92	16660											
POU4F2	5458	broad.mit.edu	37	chr4	147561489	147561489	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatgagcgacgtggacgcCgacccgcgggacctggaggc	7	4	17	13	6	0	1	0	1	0	0	0	6	0	4	3	4	2	1	3	4	0	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:147561489C>A	uc003ikv.2	+	2	1007	c.759C>A	c.(757-759)GCC>GCA	p.A253A		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	253	POU-specific.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					ACGTGGACGCCGACCCGCGGG	0.682													13	3					4.36969e-10	6.73969e-10	1	0	A	147561489	A	A	147561489	2	1	84	1	0	0	0	0	0	0	0	1	12334	639	23	3		3	POU4F2	4	147561489	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	13488917	147561489	43592787	93	16661											
FBXW7	55294	broad.mit.edu	37	chr4	153247228	153247228	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagtctctggatcccacAcctttaccataaaatcatat	12	14	3	12	0	3	0	2	0	1	0	5	1	4	1	3	1	1	0	3	1	4	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:153247228A>T	uc003ims.2	-	10	1723	c.1574T>A	c.(1573-1575)GTG>GAG	p.V525E	FBXW7_uc011cii.1_Missense_Mutation_p.V525E|FBXW7_uc003imt.2_Missense_Mutation_p.V525E|FBXW7_uc011cih.1_Missense_Mutation_p.V349E|FBXW7_uc003imq.2_Missense_Mutation_p.V445E|FBXW7_uc003imr.2_Missense_Mutation_p.V407E	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	525	WD 4.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGGATCCCACACCTTTACCAT	0.428			Mis|N|D|F		colorectal|endometrial|T-ALL								39	30					0	0	0	0	T	153247228	T	T	153247228	3	4	84	1	0	0	0	0	1	0	0	0	5801	159	6	5	561	5	FBXW7	4	153247228	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	5685739	153247228	37907048	94	16662											
RXFP1	59350	broad.mit.edu	37	chr4	159568073	159568073	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcttgtaggatctttggcCattctgtccacagaagtatc	9	13	9	10	0	2	1	0	0	2	1	4	2	3	2	2	2	1	3	2	2	3	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:159568073C>A	uc003ipz.2	+	16	1558	c.1476C>A	c.(1474-1476)GCC>GCA	p.A492A	RXFP1_uc011cja.1_Silent_p.A387A|RXFP1_uc010iqo.2_Silent_p.A444A|RXFP1_uc011cjb.1_Silent_p.A390A|RXFP1_uc010iqk.2_Silent_p.A360A|RXFP1_uc011cjc.1_Silent_p.A411A|RXFP1_uc011cjd.1_Silent_p.A411A|RXFP1_uc010iql.2_Silent_p.A336A|RXFP1_uc011cje.1_Silent_p.A519A|RXFP1_uc010iqm.2_Silent_p.A459A|RXFP1_uc011cjf.1_Silent_p.A361A|RXFP1_uc010iqn.2_Silent_p.A437A	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	492	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		GATCTTTGGCCATTCTGTCCA	0.408													29	21					1.08312e-15	1.78743e-15	1	0	A	159568073	A	A	159568073	2	1	84	1	0	0	0	0	0	0	0	1	13824	581	21	4		4	RXFP1	4	159568073	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	6320845	159568073	31586203	95	16663											
MARCH1	55016	broad.mit.edu	37	chr4	164534544	164534544	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctgttgttgggctgcttGcctggagaaacaagttagat	8	13	12	8	0	0	2	0	0	0	2	1	3	1	2	2	2	3	5	2	2	3	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:164534544G>T	uc003iqs.1	-	5	1141	c.164C>A	c.(163-165)GCA>GAA	p.A55E	MARCH1_uc003iqr.1_Missense_Mutation_p.A38E	NM_017923	NP_060393	Q8TCQ1	MARH1_HUMAN	membrane-associated RING-CH protein I	55	Responsible for low stability (By similarity).				antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGGGCTGCTTGCCTGGAGAAA	0.413													18	19					3.51602e-12	5.59926e-12	1	0	T	164534544	T	T	164534544	3	4	84	1	0	0	0	0	1	0	0	0	9351	1333	46	4	721	4	MARCH1	4	164534544	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	4966471	164534544	26619732	96	16664											
TRIML2	205860	broad.mit.edu	37	chr4	189012609	189012609	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtgtctccatttgggataCagagggaaaacacaggcctg	11	10	12	8	0	1	1	0	0	1	1	2	3	1	3	2	3	2	0	2	3	3	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr4:189012609C>A	uc003izl.2	-	7	1118	c.1082G>T	c.(1081-1083)TGT>TTT	p.C361F	TRIML2_uc003izj.1_Missense_Mutation_p.C189F|TRIML2_uc003izk.1_Missense_Mutation_p.C169F|TRIML2_uc011cle.1_Missense_Mutation_p.C436F	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	361	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		ATTTGGGATACAGAGGGAAAA	0.463													45	71					1.89013e-27	3.42048e-27	1	0	A	189012609	A	A	189012609	3	1	84	1	0	0	0	0	1	0	0	0	16618	478	17	4	85	4	TRIML2	4	189012609	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	24478065	189012609	2141667	97	16665											
SLC12A7	10723	broad.mit.edu	37	chr5	1094289	1094289	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgaaaagtgccatgttctTcccttcaaagaagctctctt	10	13	6	12	1	3	1	1	0	2	1	6	2	4	1	2	0	2	2	2	0	4	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:1094289T>C	uc003jbu.2	-	2	265	c.199A>G	c.(199-201)AAG>GAG	p.K67E		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	67	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GCCATGTTCTTCCCTTCAAAG	0.468													6	98					0	0	0	0	C	1094289	C	C	1094289	3	2	84	1	0	0	0	0	1	0	0	0	14453	1792	62	5	3144	5	SLC12A7	5	1094289	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08		1094289	179820971	98	16666											
IRX2	153572	broad.mit.edu	37	chr5	2749623	2749623	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcggggcccaggtcatcttGttctccttcttgaggcgccg	3	12	12	14	3	4	1	1	1	3	0	6	1	4	1	3	4	0	1	3	4	0	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:2749623G>C	uc003jda.2	-	2	770	c.528C>G	c.(526-528)AAC>AAG	p.N176K	C5orf38_uc003jdc.2_5'Flank|C5orf38_uc011cmg.1_5'Flank|C5orf38_uc011cmh.1_5'Flank|C5orf38_uc011cmi.1_5'Flank|C5orf38_uc011cmj.1_5'Flank|IRX2_uc003jdb.2_Missense_Mutation_p.N176K	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	176						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		AGGTCATCTTGTTCTCCTTCT	0.602													45	78					0	0	0	0	C	2749623	C	C	2749623	3	2	84	1	0	0	0	0	1	0	0	0	7883	1368	48	4	899	4	IRX2	5	2749623	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1655334	2749623	178165637	99	16667											
KIAA0947	23379	broad.mit.edu	37	chr5	5457653	5457653	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgaccatgtttttaatgaGaatggaaatcttgaggtttt	11	17	9	4	0	2	3	0	3	2	1	2	5	2	4	1	2	0	2	1	2	3	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:5457653G>T	uc003jdm.3	+	12	1122	c.900G>T	c.(898-900)GAG>GAT	p.E300D		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	300										ovary(1)|central_nervous_system(1)	2						TTTTTAATGAGAATGGAAATC	0.358													31	52					1.30897e-18	2.25966e-18	1	0	T	5457653	T	T	5457653	3	4	84	1	0	0	0	0	1	0	0	0	8241	933	33	2	946	2	KIAA0947	5	5457653	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2708030	5457653	175457607	100	16668											
ADCY2	108	broad.mit.edu	37	chr5	7826964	7826964	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgtcaaggtccctttccCagagcaacgtggcatcctga	11	9	9	12	1	1	2	1	1	0	1	4	2	4	2	3	2	2	2	3	2	3	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:7826964C>A	uc003jdz.1	+	25	3323	c.3256C>A	c.(3256-3258)CAG>AAG	p.Q1086K	ADCY2_uc011cmo.1_Missense_Mutation_p.Q906K|ADCY2_uc010itm.1_Missense_Mutation_p.Q282K	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	1086	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GTCCCTTTCCCAGAGCAACGT	0.468													44	72					4.01344e-20	7.06232e-20	1	0	A	7826964	A	A	7826964	3	1	84	1	0	0	0	0	1	0	0	0	294	595	21	4	3354	4	ADCY2	5	7826964	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2369311	7826964	173088296	101	16669											
MARCH6	10299	broad.mit.edu	37	chr5	10405687	10405687	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caggtacttcgacctggtgtCctgtggtttctaaggaattt	7	15	11	8	1	1	0	0	0	1	0	3	2	2	1	2	4	1	2	2	4	3	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:10405687C>T	uc003jet.1	+	16	1533	c.1350C>T	c.(1348-1350)GTC>GTT	p.V450V	MARCH6_uc011cmu.1_Silent_p.V402V|MARCH6_uc003jeu.1_Silent_p.V148V|MARCH6_uc011cmv.1_Silent_p.V345V	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	450	Cytoplasmic (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						GACCTGGTGTCCTGTGGTTTC	0.323													38	43					0	0	0	0	T	10405687	T	T	10405687	2	4	84	1	0	0	0	0	0	0	0	1	9358	842	30	2		2	MARCH6	5	10405687	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2578723	10405687	170509573	102	16670											
HEATR7B2	133558	broad.mit.edu	37	chr5	41048473	41048473	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacgtgttttccataggtctAccaattttgggtgaattatc	10	16	8	7	1	1	1	0	1	1	0	3	1	2	1	2	2	2	1	2	2	6	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:41048473A>G	uc003jmj.3	-	16	2127	c.1637T>C	c.(1636-1638)GTA>GCA	p.V546A	HEATR7B2_uc003jmi.3_Missense_Mutation_p.V101A	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	546	HEAT 6.						binding			ovary(6)|central_nervous_system(2)	8						CCATAGGTCTACCAATTTTGG	0.473													34	72					0	0	0	0	G	41048473	G	G	41048473	3	3	84	1	0	0	0	0	1	0	0	0	7074	391	14	5	3228	5	HEATR7B2	5	41048473	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	30642786	41048473	139866787	103	16671											
ZNF131	7690	broad.mit.edu	37	chr5	43161390	43161390	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttagaggaaaataccacAggaaaaaatgaggccaaaaa	21	4	8	8	0	0	2	0	1	0	1	0	4	0	4	3	3	1	0	3	3	9	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:43161390A>T	uc011cpw.1	+	5	447	c.411A>T	c.(409-411)ACA>ACT	p.T137T	ZNF131_uc010ivl.1_Silent_p.T137T|ZNF131_uc003jnj.3_5'UTR|ZNF131_uc003jnk.2_Silent_p.T137T|ZNF131_uc003jnn.3_5'UTR|ZNF131_uc003jnl.1_Intron|ZNF131_uc010ivm.1_Intron	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	137						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AAAATACCACAGGAAAAAATG	0.318													18	46					0	0	0	0	T	43161390	T	T	43161390	2	4	84	1	0	0	0	0	0	0	0	1	17788	175	7	5		5	ZNF131	5	43161390	Silent	SNP	A	TCGA-CN-6992-01A-11D-1912-08	2112917	43161390	137753870	104	16672											
HCN1	348980	broad.mit.edu	37	chr5	45262557	45262557	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcatagtggaaagttcgagcGgccagagggctctgtacagg	10	7	16	8	2	1	1	0	0	1	1	2	3	1	2	1	4	2	4	1	4	3	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:45262557G>C	uc003jok.2	-	8	2164	c.2139C>G	c.(2137-2139)GCC>GCG	p.A713A		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	713	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AAGTTCGAGCGGCCAGAGGGC	0.488													7	17					0	0	0	0	C	45262557	C	C	45262557	2	2	84	1	0	0	0	0	0	0	0	1	7035	1103	39	3		3	HCN1	5	45262557	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2101167	45262557	135652703	105	16673											
HCN1	348980	broad.mit.edu	37	chr5	45396705	45396705	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atcatgctcagcatggtaatCcagaggtcagacatgctgac	12	9	10	10	0	3	3	3	1	0	2	4	3	4	3	1	2	3	4	1	2	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:45396705C>A	uc003jok.2	-	4	1144	c.1119G>T	c.(1117-1119)TGG>TGT	p.W373C		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	373	Helical; Name=Segment S6; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GCATGGTAATCCAGAGGTCAG	0.532													21	64					2.4624e-09	3.72576e-09	1	0	A	45396705	A	A	45396705	3	1	84	1	0	0	0	0	1	0	0	0	7035	856	30	2	1573	2	HCN1	5	45396705	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	134148	45396705	135518555	106	16674											
HCN1	348980	broad.mit.edu	37	chr5	45695881	45695881	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cggagggagaatttgttgacCccgggctgcagcatggaggt	8	8	17	8	2	0	2	0	1	0	1	0	5	0	4	2	5	2	4	2	5	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:45695881C>A	uc003jok.2	-	1	340	c.315G>T	c.(313-315)GGG>GGT	p.G105G		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	105	Involved in subunit assembly (By similarity).|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ATTTGTTGACCCCGGGCTGCA	0.577													15	36					0.000422831	0.000590666	1	0	A	45695881	A	A	45695881	2	1	84	1	0	0	0	0	0	0	0	1	7035	610	22	4		4	HCN1	5	45695881	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	299176	45695881	135219379	107	16675											
ZNF366	167465	broad.mit.edu	37	chr5	71756259	71756259	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactggcgtgcttggcttcGtgggccttgagctcgctggg	2	11	16	12	3	0	1	0	1	0	0	2	1	0	1	2	4	2	4	2	4	0	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:71756259G>A	uc003kce.1	-	2	1251	c.1065C>T	c.(1063-1065)CAC>CAT	p.H355H		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	355	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GCTTGGCTTCGTGGGCCTTGA	0.662													5	8					0	0	0	0	A	71756259	A	A	71756259	2	1	84	1	0	0	0	0	0	0	0	1	17937	1136	40	1		1	ZNF366	5	71756259	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	26060378	71756259	109159001	108	16676											
LIX1	167410	broad.mit.edu	37	chr5	96443064	96443064	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctccatggtgggtactcacGctggtggaggctactgcttc	5	11	13	12	1	1	0	1	0	0	0	3	1	2	1	2	5	3	4	2	5	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:96443064G>T	uc003kmy.3	-	3	627	c.387C>A	c.(385-387)AGC>AGA	p.S129R		NM_153234	NP_694966	Q8N485	LIX1_HUMAN	limb expression 1	129										ovary(1)	1		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		GGGTACTCACGCTGGTGGAGG	0.463													24	25					5.45024e-15	8.92494e-15	1	0	T	96443064	T	T	96443064	3	4	84	1	0	0	0	0	1	0	0	0	8873	1101	38	3	477	3	LIX1	5	96443064	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	24686805	96443064	84472196	109	16677											
PCDHB7	56129	broad.mit.edu	37	chr5	140553886	140553886	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcccaggtcatctactccctGctgccgtcccaggacccgca	6	7	9	19	2	2	0	1	0	1	0	4	1	4	1	5	2	3	2	5	2	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:140553886G>C	uc003lit.2	+	1	1644	c.1470G>C	c.(1468-1470)CTG>CTC	p.L490L		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	490	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTACTCCCTGCTGCCGTCCC	0.662													41	37					0	0	0	0	C	140553886	C	C	140553886	2	2	84	1	0	0	0	0	0	0	0	1	11601	1306	46	4		4	PCDHB7	5	140553886	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	44110822	140553886	40361374	110	16678											
PCDHB9	56127	broad.mit.edu	37	chr5	140568207	140568207	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccgagcacagcataacccTgcaggtctccgacgtcaatg	12	6	9	14	3	2	0	1	0	1	0	3	2	2	0	3	1	5	3	3	1	3	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:140568207T>A	uc003liw.1	+	3	1316	c.1316T>A	c.(1315-1317)CTG>CAG	p.L439Q		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	439	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCATAACCCTGCAGGTCTCC	0.582													64	33					0	0	0	0	A	140568207	A	A	140568207	3	1	84	1	0	0	0	0	1	0	0	0	11603	1580	55	5	1317	5	PCDHB9	5	140568207	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	14321	140568207	40347053	111	16679											
PCDHGB3	56102	broad.mit.edu	37	chr5	140751528	140751528	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagcgagccttcgaccacGagcagctgcgtgccttcgag	7	6	13	15	6	0	0	0	0	0	0	2	4	0	0	3	0	6	3	3	0	0	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:140751528G>T	uc003ljw.1	+	1	1567	c.1567G>T	c.(1567-1569)GAG>TAG	p.E523*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Nonsense_Mutation_p.E523*|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	523	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCGACCACGAGCAGCTGCG	0.687													13	19					1.5842e-08	2.36332e-08	1	0	T	140751528	T	T	140751528	4	4	84	1	0	0	0	0	0	1	0	0	11618	1059	37	3	1569	3	PCDHGB3	5	140751528	Nonsense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	183321	140751528	40163732	112	16680											
DOCK2	1794	broad.mit.edu	37	chr5	169509800	169509800	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttgtttattctctcaaaagCtggccagcaaatcggctgaa	11	12	8	10	1	2	1	1	1	1	0	4	1	2	1	1	2	2	4	1	2	5	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:169509800C>T	uc003maf.2	+	52	5511	c.5431C>T	c.(5431-5433)CTG>TTG	p.L1811L	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.L1303L|DOCK2_uc003mah.2_Silent_p.L367L	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1811					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCTCAAAAGCTGGCCAGCAA	0.512													19	16					0	0	0	0	T	169509800	T	T	169509800	2	4	84	1	0	0	0	0	0	0	0	1	4709	811	28	4		4	DOCK2	5	169509800	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	28758272	169509800	11405460	113	16681											
GABRP	2568	broad.mit.edu	37	chr5	170238960	170238960	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgcattgtctatgaactagGggacaacaaaggaagtagaa	16	8	11	6	0	1	2	0	1	1	1	1	4	1	4	0	3	3	2	0	3	8	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:170238960G>A	uc003mau.2	+	10	1219	c.1021G>A	c.(1021-1023)GGG>AGG	p.G341R	GABRP_uc011dev.1_Missense_Mutation_p.G278E	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	341	Cytoplasmic (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TATGAACTAGGGGACAACAAA	0.358													27	19					0	0	0	0	A	170238960	A	A	170238960	3	1	84	1	0	0	0	0	1	0	0	0	6208	1246	43	4	1055	4	GABRP	5	170238960	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	729160	170238960	10676300	114	16682											
TBC1D9B	23061	broad.mit.edu	37	chr5	179296770	179296770	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggcaggaggctctcaccTgggggaaggtgtagcttgta	7	9	18	7	0	1	0	1	0	1	0	2	2	1	2	1	6	1	5	1	6	3	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:179296770T>A	uc003mlh.2	-	17	2827	c.2790A>T	c.(2788-2790)CCA>CCT	p.P930P	TBC1D9B_uc003mli.2_Silent_p.P930P|TBC1D9B_uc003mlj.2_Silent_p.P930P|TBC1D9B_uc003mlf.2_5'Flank|TBC1D9B_uc003mlg.2_Silent_p.P106P|TBC1D9B_uc011dgv.1_Silent_p.P106P|TBC1D9B_uc011dgw.1_Silent_p.P106P|TBC1D9B_uc003mlk.1_Silent_p.P88P	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	930						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCTCTCACCTGGGGGAAGGT	0.632													6	7					0	0	0	0	A	179296770	A	A	179296770	2	1	84	1	0	0	0	0	0	0	0	1	15694	1594	55	5		5	TBC1D9B	5	179296770	Silent	SNP	T	TCGA-CN-6992-01A-11D-1912-08	9057810	179296770	1618490	115	16683											
MGAT1	4245	broad.mit.edu	37	chr5	180218667	180218667	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatcatagccctcccacgtCagtgggggcgccaggtggac	7	6	15	13	2	2	0	2	0	0	0	3	2	3	2	3	5	1	0	3	5	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:180218667C>A	uc003mmg.3	-	2	1800	c.1305G>T	c.(1303-1305)CTG>CTT	p.L435L	MGAT1_uc010jlf.2_Silent_p.L435L|MGAT1_uc010jlg.2_Silent_p.L435L|MGAT1_uc003mmh.3_Silent_p.L435L|MGAT1_uc010jlh.2_Silent_p.L435L|MGAT1_uc003mmi.3_Silent_p.L435L	NM_002406	NP_002397	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein	435	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(1)	1	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTCCCACGTCAGTGGGGGCG	0.622													19	20					5.35356e-11	8.39955e-11	1	0	A	180218667	A	A	180218667	2	1	84	1	0	0	0	0	0	0	0	1	9595	813	29	2		2	MGAT1	5	180218667	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	921897	180218667	696593	116	16684											
BTNL3	10917	broad.mit.edu	37	chr5	180429673	180429673	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgggactgtttttcagaGacgtttttccagccctcacc	6	14	9	12	1	2	1	2	0	0	1	3	3	3	2	3	1	1	2	3	1	0	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr5:180429673G>A	uc003mmr.2	+	4	803	c.675G>A	c.(673-675)GAG>GAA	p.E225E	BTNL3_uc010jlp.2_5'UTR	NM_197975	NP_932079	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3 precursor	225	Extracellular (Potential).				lipid metabolic process	integral to membrane					0	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GTTTTTCAGAGACGTTTTTCC	0.458													28	17					0	0	0	0	A	180429673	A	A	180429673	2	1	84	1	0	0	0	0	0	0	0	1	1571	956	33	2		2	BTNL3	5	180429673	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	211006	180429673	485587	117	16685											
GCNT2	2651	broad.mit.edu	37	chr6	10529180	10529180	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcactgtctttttagcgcGtctcttatctctgccctgat	6	16	7	12	2	3	1	0	1	3	0	5	1	3	1	1	0	3	1	1	0	3	4	rs142352495	by1000genomes	TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:10529180G>A	uc010joo.2	+	3	587	c.36G>A	c.(34-36)GCG>GCA	p.A12A	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Silent_p.A11A|GCNT2_uc010jon.2_Silent_p.A11A	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	12	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TTTTTAGCGCGTCTCTTATCT	0.388													19	81					0	0	0	0	A	10529180	A	A	10529180	2	1	84	1	0	0	0	0	0	0	0	1	6336	1132	40	1		1	GCNT2	6	10529180	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08		10529180	160585887	118	16686											
KIAA0319	9856	broad.mit.edu	37	chr6	24581232	24581232	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gactttgaagacataaagtcCgacggacaactgtaacataa	17	8	8	8	2	0	2	0	1	0	1	1	5	1	3	1	1	2	1	1	1	6	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:24581232C>T	uc011djo.1	-	7	1438	c.1201G>A	c.(1201-1203)GGA>AGA	p.G401R	KIAA0319_uc011djp.1_Missense_Mutation_p.G356R|KIAA0319_uc003neh.1_Missense_Mutation_p.G401R|KIAA0319_uc011djq.1_Missense_Mutation_p.G392R|KIAA0319_uc011djr.1_Missense_Mutation_p.G401R|KIAA0319_uc010jpt.1_5'UTR	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	401	PKD 1.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						ACATAAAGTCCGACGGACAAC	0.423											OREG0017229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	105					0	0	0	0	T	24581232	T	T	24581232	3	4	84	1	0	0	0	0	1	0	0	0	8207	661	23	1	2077	1	KIAA0319	6	24581232	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	14052052	24581232	146533835	119	16687											
PGBD1	84547	broad.mit.edu	37	chr6	28269721	28269721	+	Frame_Shift_Del	DEL	T	-	-																															tggggatggcattatcagtcTgtgctccaatgctgtgggca																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:28269721delT	uc003nky.2	+	7	2460	c.2090delT	c.(2089-2091)CTGfs	p.L697fs	PGBD1_uc003nkz.2_Frame_Shift_Del_p.L697fs	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	697					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						ATTATCAGTCTGTGCTCCAAT	0.383													---	---	---								-	28269721	-	-	28269721	7	5	84	1	0	1	0	1	0	0	0	0	11835	1580	55	0	2112	0	PGBD1	6	28269721	Frame_Shift_Del	DEL	T	TCGA-CN-6992-01A-11D-1912-08	3688489	28269721	142845346	120	16688											
ABCF1	23	broad.mit.edu	37	chr6	30557701	30557701	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcccgcaagtgcctgggccGcttcggcctggagagtcacg	5	7	15	14	4	1	1	1	0	0	1	2	2	1	1	4	3	2	2	4	3	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:30557701G>T	uc003nql.2	+	22	2278	c.2183G>T	c.(2182-2184)CGC>CTC	p.R728L	ABCF1_uc003nqm.2_Missense_Mutation_p.R690L|ABCF1_uc010jsb.2_Missense_Mutation_p.R121L	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	728	ABC transporter 2.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						TGCCTGGGCCGCTTCGGCCTG	0.612													54	124					3.30226e-22	5.87581e-22	1	0	T	30557701	T	T	30557701	3	4	84	1	0	0	0	0	1	0	0	0	65	1087	38	3	2269	3	ABCF1	6	30557701	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2287980	30557701	140557366	121	16689											
MDC1	9656	broad.mit.edu	37	chr6	30672319	30672319	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgagatgtgggctcaggggtGacaggttggtctgtggaggt	6	10	20	5	1	2	2	1	1	1	1	2	4	2	3	0	7	0	2	0	7	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:30672319G>C	uc003nrg.3	-	10	5081	c.4641C>G	c.(4639-4641)GTC>GTG	p.V1547V	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Silent_p.V1154V	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1547	Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GCTCAGGGGTGACAGGTTGGT	0.567								Other_conserved_DNA_damage_response_genes					48	209					0	0	0	0	C	30672319	C	C	30672319	2	2	84	1	0	0	0	0	0	0	0	1	9456	1277	45	2		2	MDC1	6	30672319	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	114618	30672319	140442748	122	16690											
MDC1	9656	broad.mit.edu	37	chr6	30673202	30673202	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caggctggtctgtggaggtgGaaggctggagctcaggggct	6	8	20	7	0	2	0	1	0	1	0	2	3	2	3	0	9	1	4	0	9	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:30673202G>T	uc003nrg.3	-	10	4198	c.3758C>A	c.(3757-3759)TCC>TAC	p.S1253Y	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.S860Y	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1253	Pro-rich.|Interaction with the PRKDC complex.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TGTGGAGGTGGAAGGCTGGAG	0.532								Other_conserved_DNA_damage_response_genes					64	262					7.65386e-43	1.45538e-42	1	0	T	30673202	T	T	30673202	3	4	84	1	0	0	0	0	1	0	0	0	9456	1174	41	2	2535	2	MDC1	6	30673202	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	883	30673202	140441865	123	16691											
BAT2	7916	broad.mit.edu	37	chr6	31597550	31597550	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccgatggatgatgattcctCcttatgtggacccccggctc	6	11	10	14	2	0	2	0	2	0	0	3	5	2	4	5	3	0	1	5	3	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:31597550C>T	uc003nvb.3	+	14	2431	c.2182C>T	c.(2182-2184)CCT>TCT	p.P728S	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.P728S	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	728	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						GATGATTCCTCCTTATGTGGA	0.637													12	50					0	0	0	0	T	31597550	T	T	31597550	3	4	84	1	0	0	0	0	1	0	0	0	1321	855	30	2	2232	2	BAT2	6	31597550	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	924348	31597550	139517517	124	16692											
DAAM2	23500	broad.mit.edu	37	chr6	39869182	39869182	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caggccttctcagaggcccgGcaggatctagaggccatgag	9	6	14	12	1	2	3	1	1	2	2	3	4	2	4	3	5	0	1	3	5	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:39869182G>T	uc003oow.2	+	24	3072	c.2916G>T	c.(2914-2916)CGG>CGT	p.R972R	DAAM2_uc003oox.2_Silent_p.R971R	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	972	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CAGAGGCCCGGCAGGATCTAG	0.607													36	58					1.26612e-14	2.05744e-14	1	0	T	39869182	T	T	39869182	2	4	84	1	0	0	0	0	0	0	0	1	4233	1190	42	4		4	DAAM2	6	39869182	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	8271632	39869182	131245885	125	16693											
SLC29A1	2030	broad.mit.edu	37	chr6	44197181	44197181	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctgggaacgctgctcccGtggaattttttcatgacggc	6	12	13	10	3	2	1	1	1	1	0	3	3	3	3	1	4	2	2	1	4	2	3	rs8187630	byFrequency	TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:44197181G>A	uc003owu.1	+	3	413	c.84G>A	c.(82-84)CCG>CCA	p.P28P	SLC29A1_uc011dvp.1_Silent_p.P47P|SLC29A1_uc003owv.1_Silent_p.P28P|SLC29A1_uc003oww.1_Silent_p.P107P|SLC29A1_uc011dvq.1_Silent_p.P70P|SLC29A1_uc003owx.1_Silent_p.P28P|SLC29A1_uc003owy.1_Silent_p.P28P|SLC29A1_uc003owz.1_Silent_p.P28P	NM_004955	NP_004946	Q99808	S29A1_HUMAN	equilibrative nucleoside transporter 1	28	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			large_intestine(2)|skin(1)	3	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	CGCTGCTCCCGTGGAATTTTT	0.562													25	100					0	0	0	0	A	44197181	A	A	44197181	2	1	84	1	0	0	0	0	0	0	0	1	14598	1132	40	1		1	SLC29A1	6	44197181	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	4327999	44197181	126917886	126	16694											
OPN5	221391	broad.mit.edu	37	chr6	47775957	47775957	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtggtgtctgtgtggtCagcttttggaaggccagact	6	13	15	7	0	2	1	1	0	1	1	2	2	2	2	1	4	2	2	1	4	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:47775957C>A	uc003ozc.2	+	5	829	c.824C>A	c.(823-825)TCA>TAA	p.S275*	OPN5_uc003ozd.2_Nonsense_Mutation_p.S110*	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	275	Extracellular (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						TCTGTGTGGTCAGCTTTTGGA	0.463													71	131					5.98616e-33	1.0989e-32	1	0	A	47775957	A	A	47775957	4	1	84	1	0	0	0	0	0	1	0	0	10937	838	29	2	842	2	OPN5	6	47775957	Nonsense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3578776	47775957	123339110	127	16695											
C6orf138	442213	broad.mit.edu	37	chr6	48036041	48036041	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atattgtccccggttggggaGaggaggatcaccctgccata	9	9	13	10	1	1	1	1	0	0	1	2	4	2	3	4	5	1	1	4	5	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:48036041G>A	uc011dwm.1	-	1	385	c.300C>T	c.(298-300)CTC>CTT	p.L100L	C6orf138_uc011dwn.1_Intron|C6orf138_uc003ozf.2_Silent_p.L117L	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	117						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						CGGTTGGGGAGAGGAGGATCA	0.567													35	95					0	0	0	0	A	48036041	A	A	48036041	2	1	84	1	0	0	0	0	0	0	0	1	2342	929	33	2		2	C6orf138	6	48036041	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	260084	48036041	123079026	128	16696											
PKHD1	5314	broad.mit.edu	37	chr6	51695776	51695776	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttaaagctgattcaggggCagaggtagaagctagaaaat	15	10	12	4	0	1	4	1	1	0	3	1	4	1	4	0	3	2	4	0	3	7	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:51695776C>T	uc003pah.1	-	52	8461	c.8185G>A	c.(8185-8187)GCC>ACC	p.A2729T	PKHD1_uc010jzn.1_Missense_Mutation_p.A712T|PKHD1_uc003pai.2_Missense_Mutation_p.A2729T	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2729	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GATTCAGGGGCAGAGGTAGAA	0.393													15	32					0	0	0	0	T	51695776	T	T	51695776	3	4	84	1	0	0	0	0	1	0	0	0	12026	710	25	4	4142	4	PKHD1	6	51695776	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3659735	51695776	119419291	129	16697											
GSTA5	221357	broad.mit.edu	37	chr6	52697722	52697722	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacgtagtagaaaagttccaCcaggtgaatgtcagcccagc	13	7	10	11	1	1	2	1	1	0	1	2	2	2	2	3	1	2	3	3	1	5	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:52697722C>A	uc003pba.1	-	6	551	c.481G>T	c.(481-483)GTG>TTG	p.V161L		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	161	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	AAAAGTTCCACCAGGTGAATG	0.502													41	90					9.62906e-15	1.57275e-14	1	0	A	52697722	A	A	52697722	3	1	84	1	0	0	0	0	1	0	0	0	6873	507	18	4	195	4	GSTA5	6	52697722	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1001946	52697722	118417345	130	16698											
LGSN	51557	broad.mit.edu	37	chr6	63990707	63990707	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactctcgacattggctccaGtgtgatacaagccatcaaca	13	9	7	12	1	2	1	1	1	1	0	4	2	3	1	2	1	4	1	2	1	4	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:63990707G>T	uc003peh.2	-	4	783	c.749C>A	c.(748-750)ACT>AAT	p.T250N	LGSN_uc003pei.2_Intron	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	250					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	ATTGGCTCCAGTGTGATACAA	0.388													19	28					2.39187e-15	3.92686e-15	1	0	T	63990707	T	T	63990707	3	4	84	1	0	0	0	0	1	0	0	0	8800	1029	36	4	784	4	LGSN	6	63990707	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	11292985	63990707	107124360	131	16699											
PHF3	23469	broad.mit.edu	37	chr6	64401851	64401851	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacaatggagtgtgaaaagcTtggattatcaaaacacacaa	19	8	8	6	0	1	1	1	1	0	0	1	3	1	3	0	2	3	1	0	2	8	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:64401851T>G	uc003pep.1	+	4	2440	c.2414T>G	c.(2413-2415)CTT>CGT	p.L805R	PHF3_uc010kaf.1_Missense_Mutation_p.L805R|PHF3_uc003pem.2_Missense_Mutation_p.L758R|PHF3_uc010kag.1_Missense_Mutation_p.L717R|PHF3_uc010kah.1_Missense_Mutation_p.L619R|PHF3_uc003pen.2_Missense_Mutation_p.L717R|PHF3_uc011dxs.1_Missense_Mutation_p.L74R	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	805					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TGTGAAAAGCTTGGATTATCA	0.338													12	20					0	0	0	0	G	64401851	G	G	64401851	3	3	84	1	0	0	0	0	1	0	0	0	11891	1609	56	5	2428	5	PHF3	6	64401851	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	411144	64401851	106713216	132	16700											
DPPA5	340168	broad.mit.edu	37	chr6	74063748	74063748	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtaagggattcgagatccGtccgggcctgttggggaaaa	10	9	15	7	3	0	1	0	0	0	1	3	4	2	3	3	4	0	2	3	4	3	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:74063748G>A	uc003pgs.1	-	2	125	c.120C>T	c.(118-120)GAC>GAT	p.D40D		NM_001025290	NP_001020461	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	40	KH; atypical.				multicellular organismal development	cytoplasm	RNA binding				0						TTCGAGATCCGTCCGGGCCTG	0.612													11	40					0	0	0	0	A	74063748	A	A	74063748	2	1	84	1	0	0	0	0	0	0	0	1	4759	1136	40	1		1	DPPA5	6	74063748	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	9661897	74063748	97051319	133	16701											
SNAP91	9892	broad.mit.edu	37	chr6	84302213	84302213	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctgaagaatccacctttgCtggcgaggcagtggttgcag	9	9	13	10	1	0	2	0	1	0	1	1	3	1	2	3	3	2	4	3	3	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:84302213C>G	uc011dze.1	-	20	2208	c.1891G>C	c.(1891-1893)GCA>CCA	p.A631P	SNAP91_uc011dzd.1_Missense_Mutation_p.A134P|SNAP91_uc003pkb.2_Intron|SNAP91_uc003pkc.2_Intron|SNAP91_uc003pkd.2_Intron|SNAP91_uc003pka.2_Missense_Mutation_p.A629P	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	631					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TCCACCTTTGCTGGCGAGGCA	0.438													6	14					0	0	0	0	G	84302213	G	G	84302213	3	3	84	1	0	0	0	0	1	0	0	0	14897	797	28	4	868	4	SNAP91	6	84302213	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	10238465	84302213	86812854	134	16702											
CGA	1081	broad.mit.edu	37	chr6	87796070	87796070	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagtgggatatgctctagaGaagcagcagcccatgcactg	11	7	14	9	0	1	1	0	0	1	1	1	4	1	3	1	2	5	4	1	2	3	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:87796070G>C	uc003plj.1	-	3	272	c.171C>G	c.(169-171)TTC>TTG	p.F57L		NM_000735	NP_000726	P01215	GLHA_HUMAN	glycoprotein hormones, alpha polypeptide	57					hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			ovary(1)	1		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)		ATGCTCTAGAGAAGCAGCAGC	0.473													50	113					0	0	0	0	C	87796070	C	C	87796070	3	2	84	1	0	0	0	0	1	0	0	0	3310	933	33	2	187	2	CGA	6	87796070	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3493857	87796070	83318997	135	16703											
GPRC6A	222545	broad.mit.edu	37	chr6	117150007	117150007	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactcctggatttgtggtCgtctgggagagtcttctgag	6	13	13	9	1	3	2	0	1	3	1	5	4	4	3	1	3	0	0	1	3	0	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:117150007C>A	uc003pxj.1	-	1	192	c.170G>T	c.(169-171)CGA>CTA	p.R57L	GPRC6A_uc003pxk.1_Missense_Mutation_p.R57L|GPRC6A_uc003pxl.1_Missense_Mutation_p.R57L	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	57	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		GATTTGTGGTCGTCTGGGAGA	0.403													11	55					1.61879e-10	2.5212e-10	1	0	A	117150007	A	A	117150007	3	1	84	1	0	0	0	0	1	0	0	0	6767	884	31	3	2634	3	GPRC6A	6	117150007	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	29353937	117150007	53965060	136	16704											
ROS1	6098	broad.mit.edu	37	chr6	117678071	117678071	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attggaaacttctgtccaatAcaagcgactatagaggaaaa	17	9	8	7	1	1	1	0	0	1	1	2	4	2	3	1	2	3	0	1	2	8	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:117678071A>C	uc003pxp.1	-	25	4061	c.3862T>G	c.(3862-3864)TAT>GAT	p.Y1288D	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1288	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TCTGTCCAATACAAGCGACTA	0.378			T	GOPC|ROS1	glioblastoma|NSCLC								3	45					0	0	0	0	C	117678071	C	C	117678071	3	2	84	1	0	0	0	0	1	0	0	0	13596	391	14	5	3257	5	ROS1	6	117678071	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	528064	117678071	53436996	137	16705											
CLVS2	134829	broad.mit.edu	37	chr6	123369837	123369837	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtatatccatgccctgtacaCcgtgatccggcctttcctga	7	12	8	14	2	0	2	0	2	0	0	3	2	3	2	6	1	2	2	6	1	3	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:123369837C>T	uc003pzi.1	+	4	1504	c.635C>T	c.(634-636)ACC>ATC	p.T212I		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	212	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GCCCTGTACACCGTGATCCGG	0.393													61	127					0	0	0	0	T	123369837	T	T	123369837	3	4	84	1	0	0	0	0	1	0	0	0	3587	507	18	4	645	4	CLVS2	6	123369837	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	5691766	123369837	47745230	138	16706											
OLIG3	167826	broad.mit.edu	37	chr6	137814987	137814987	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgcgtagggcatgacttcGcgcagcccgtccatggctag	6	8	14	13	5	0	1	0	1	0	0	2	1	1	1	2	2	2	4	2	2	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:137814987G>A	uc003qhp.1	-	1	545	c.321C>T	c.(319-321)CGC>CGT	p.R107R		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	107	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		GCATGACTTCGCGCAGCCCGT	0.612													17	73					0	0	0	0	A	137814987	A	A	137814987	2	1	84	1	0	0	0	0	0	0	0	1	10916	1074	38	1		1	OLIG3	6	137814987	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	14445150	137814987	33300080	139	16707											
SHPRH	257218	broad.mit.edu	37	chr6	146271502	146271503	+	Missense_Mutation	DNP	CC	AT	AT																															caatgcaggatgctggacatCcacttggatggactgcgttt																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:146271502_146271503CC>AT	uc003qlf.2	-	4	1278_1279	c.879_880GG>AT	c.(877-882)GTGGAT>GTATAT	p.D294Y	SHPRH_uc003qld.2_Missense_Mutation_p.D294Y|SHPRH_uc003qle.2_Missense_Mutation_p.D294Y|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Missense_Mutation_p.D183Y|SHPRH_uc003qlk.1_Missense_Mutation_p.D294Y	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	294					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TGCTGGACATCCACTTGGATGG	0.475													51	96					0	0	0	0	AT	146271503	AT	AT	146271502	3	1	84	1	0	0	0	0	1	0	0	0	14356	855	30	2	4323	2	SHPRH	6	146271502	Missense_Mutation	DNP	CC	TCGA-CN-6992-01A-11D-1912-08	8456515	146271502	24843565	140	16708											
PLEKHG1	57480	broad.mit.edu	37	chr6	151055105	151055105	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagtggagagtggactcaaaCggggcacccaagacgatcgc	12	4	14	11	3	1	2	1	0	0	2	2	5	1	3	1	4	1	1	1	4	2	0	rs141401834		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:151055105C>T	uc003qny.1	+	3	600	c.288C>T	c.(286-288)AAC>AAT	p.N96N	PLEKHG1_uc011eel.1_Silent_p.N136N|PLEKHG1_uc011eem.1_Silent_p.N155N|PLEKHG1_uc003qnz.2_Silent_p.N96N	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	96					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		TGGACTCAAACGGGGCACCCA	0.592													9	51					0	0	0	0	T	151055105	T	T	151055105	2	4	84	1	0	0	0	0	0	0	0	1	12123	535	19	1		1	PLEKHG1	6	151055105	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	4783603	151055105	20059962	141	16709											
AKAP12	9590	broad.mit.edu	37	chr6	151671537	151671537	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaagccggaagaaccaaagCgcaaggtggatacctcagta	16	4	11	10	2	1	1	1	0	0	1	1	3	1	3	3	3	4	2	3	3	7	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:151671537C>T	uc011eep.1	+	4	2251	c.2011C>T	c.(2011-2013)CGC>TGC	p.R671C	AKAP12_uc003qoe.2_Missense_Mutation_p.R671C|AKAP12_uc003qof.2_Missense_Mutation_p.R573C|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.R566C	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	671					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		AGAACCAAAGCGCAAGGTGGA	0.507													7	57					0	0	0	0	T	151671537	T	T	151671537	3	4	84	1	0	0	0	0	1	0	0	0	448	768	27	1	2050	1	AKAP12	6	151671537	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	616432	151671537	19443530	142	16710											
C6orf118	168090	broad.mit.edu	37	chr6	165715112	165715112	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctcccagtgaagtcattCttcaggagatcttgcttggc	7	14	10	10	0	4	2	2	1	2	1	5	3	5	2	1	2	2	2	1	2	1	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:165715112C>A	uc003qum.3	-	2	735	c.699G>T	c.(697-699)AAG>AAT	p.K233N	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	233											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TGAAGTCATTCTTCAGGAGAT	0.607													21	41					1.01871e-10	1.5944e-10	1	0	A	165715112	A	A	165715112	3	1	84	1	0	0	0	0	1	0	0	0	2333	912	32	2	742	2	C6orf118	6	165715112	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	14043575	165715112	5399955	143	16711											
FAM120B	84498	broad.mit.edu	37	chr6	170628053	170628053	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagactccatgtgtacacaCgctgaaatcaatcaaaaatt	17	9	6	9	1	2	2	2	1	0	1	3	3	3	2	1	0	1	2	1	0	6	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr6:170628053C>A	uc003qxp.2	+	2	1683	c.1575C>A	c.(1573-1575)CAC>CAA	p.H525Q	FAM120B_uc003qxo.1_Missense_Mutation_p.H525Q|FAM120B_uc011ehd.1_Intron	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	525					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		TGTGTACACACGCTGAAATCA	0.378													15	42					1.3612e-06	1.97514e-06	1	0	A	170628053	A	A	170628053	3	1	84	1	0	0	0	0	1	0	0	0	5445	535	19	3	1577	3	FAM120B	6	170628053	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	4912941	170628053	487014	144	16712											
GNA12	2768	broad.mit.edu	37	chr7	2834632	2834632	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccagagtgcgctcagggccGggacgtacagctggaaggtg	8	6	17	10	3	1	1	1	0	0	1	2	3	2	3	2	4	3	3	2	4	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:2834632G>A	uc003smu.2	-	2	619	c.455C>T	c.(454-456)CCG>CTG	p.P152L	GNA12_uc011jwb.1_Missense_Mutation_p.P152L|GNA12_uc003smt.2_Missense_Mutation_p.P93L	NM_007353	NP_031379	Q03113	GNA12_HUMAN	guanine nucleotide binding protein (G protein)	152					G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.02e-13)		GCTCAGGGCCGGGACGTACAG	0.592													5	107					0	0	0	0	A	2834632	A	A	2834632	3	1	84	1	0	0	0	0	1	0	0	0	6537	1116	39	1	702	1	GNA12	7	2834632	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08		2834632	156304031	145	16713											
HERPUD2	64224	broad.mit.edu	37	chr7	35674850	35674850	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgtgagaacgtgtacatcCagtctagccagtctcgattg	9	11	10	11	3	2	1	0	1	2	1	5	3	3	1	2	0	3	1	2	0	3	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:35674850C>T	uc003tet.2	-	6	1641	c.836G>A	c.(835-837)TGG>TAG	p.W279*	HERPUD2_uc003tes.3_Nonsense_Mutation_p.W279*	NM_022373	NP_071768	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	279					response to unfolded protein	integral to membrane				ovary(3)	3						CGTGTACATCCAGTCTAGCCA	0.433													65	39					0	0	0	0	T	35674850	T	T	35674850	4	4	84	1	0	0	0	0	0	1	0	0	7103	595	21	4	396	4	HERPUD2	7	35674850	Nonsense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	32840218	35674850	123463813	146	16714											
IGFBP1	3484	broad.mit.edu	37	chr7	45928415	45928415	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcggaggtcacccggtccgCcggctgcggctgttgcccga	3	7	15	16	6	1	0	1	0	0	0	3	2	2	1	4	5	2	3	4	5	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:45928415C>A	uc003tnp.2	+	1	457	c.164C>A	c.(163-165)GCC>GAC	p.A55D	IGFBP1_uc003tno.3_Missense_Mutation_p.A55D|IGFBP1_uc010kyn.2_Missense_Mutation_p.A55D	NM_000596	NP_000587	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	55	IGFBP N-terminal.					extracellular space	insulin-like growth factor binding			lung(1)	1						ACCCGGTCCGCCGGCTGCGGC	0.771													7	12					1.06961e-07	1.57354e-07	1	0	A	45928415	A	A	45928415	3	1	84	1	0	0	0	0	1	0	0	0	7617	739	26	4	166	4	IGFBP1	7	45928415	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	10253565	45928415	113210248	147	16715											
SEPT14	346288	broad.mit.edu	37	chr7	55914269	55914269	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atctgctcaccaactgattgGgcaaacattcaaaaccaaaa	17	8	5	11	0	3	1	2	1	1	0	3	1	3	1	2	1	4	2	2	1	6	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:55914269G>T	uc003tqz.2	-	3	233	c.116C>A	c.(115-117)CCC>CAC	p.P39H		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	39					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CAACTGATTGGGCAAACATTC	0.303													50	102					1.35964e-18	2.34078e-18	1	0	T	55914269	T	T	55914269	3	4	84	1	0	0	0	0	1	0	0	0	14128	1232	43	4	1214	4	SEPT14	7	55914269	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	9985854	55914269	103224394	148	16716											
ZNF479	90827	broad.mit.edu	37	chr7	57188130	57188130	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggaccagctaaaggctttgCcacattcctcacacctgcag	11	8	8	14	0	1	0	1	0	0	0	2	1	2	1	4	2	3	3	4	2	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:57188130C>T	uc010kzo.2	-	5	1263	c.992G>A	c.(991-993)GGC>GAC	p.G331D		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	331	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			AAAGGCTTTGCCACATTCCTC	0.443													8	21					0	0	0	0	T	57188130	T	T	57188130	3	4	84	1	0	0	0	0	1	0	0	0	18000	739	26	4	586	4	ZNF479	7	57188130	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1273861	57188130	101950533	149	16717											
CLIP2	7461	broad.mit.edu	37	chr7	73753270	73753270	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggcaacgagtcgggatccaAcctctcagacagcggctctg	9	7	12	13	3	2	1	1	0	2	1	5	3	3	2	2	3	3	2	2	3	2	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:73753270A>G	uc003uam.2	+	3	941	c.614A>G	c.(613-615)AAC>AGC	p.N205S	CLIP2_uc003uan.2_Missense_Mutation_p.N205S	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	205						microtubule associated complex				skin(3)	3						TCGGGATCCAACCTCTCAGAC	0.677													16	33					0	0	0	0	G	73753270	G	G	73753270	3	3	84	1	0	0	0	0	1	0	0	0	3548	43	2	5	620	5	CLIP2	7	73753270	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	16565140	73753270	85385393	150	16718											
ZP3	7784	broad.mit.edu	37	chr7	76058904	76058904	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgggaaacctgtccatcGtgaggactaaccgcgcagag	10	6	13	12	4	0	2	0	1	0	1	2	4	1	4	4	2	2	1	4	2	2	1	rs144669807	by1000genomes	TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:76058904G>A	uc003ufd.3	+	2	395	c.385G>A	c.(385-387)GTG>ATG	p.V129M	ZP3_uc003ufc.3_Missense_Mutation_p.V78M|ZP3_uc003ufe.2_Missense_Mutation_p.V37M	NM_001110354	NP_001103824	P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 isoform 1	129	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding				0						CCTGTCCATCGTGAGGACTAA	0.597													14	58					0	0	0	0	A	76058904	A	A	76058904	3	1	84	1	0	0	0	0	1	0	0	0	18284	1145	40	1	391	1	ZP3	7	76058904	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2305634	76058904	83079759	151	16719											
CACNA2D1	781	broad.mit.edu	37	chr7	81591325	81591325	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggaggccgtgaagtcatCatcctccatctcaacttggg	9	9	11	12	1	3	1	3	1	1	0	6	2	5	2	3	3	1	0	3	3	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:81591325C>T	uc003uhr.1	-	36	3107	c.2851G>A	c.(2851-2853)GAT>AAT	p.D951N	CACNA2D1_uc011kgy.1_Missense_Mutation_p.D163N	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	963	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GTGAAGTCATCATCCTCCATC	0.483													56	544					0	0	0	0	T	81591325	T	T	81591325	3	4	84	1	0	0	0	0	1	0	0	0	2560	826	29	2	440	2	CACNA2D1	7	81591325	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	5532421	81591325	77547338	152	16720											
PCLO	27445	broad.mit.edu	37	chr7	82764156	82764156	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagattcagactgaaacGccttgactgctcctgaggct	9	10	9	13	1	1	5	1	3	0	2	3	5	3	5	3	1	2	2	3	1	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:82764156G>A	uc003uhx.2	-	3	2999	c.2710C>T	c.(2710-2712)CGT>TGT	p.R904C	PCLO_uc003uhv.2_Missense_Mutation_p.R904C	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	850	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGACTGAAACGCCTTGACTGC	0.542													26	241					0	0	0	0	A	82764156	A	A	82764156	3	1	84	1	0	0	0	0	1	0	0	0	11637	1087	38	1	12827	1	PCLO	7	82764156	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1172831	82764156	76374507	153	16721											
MCM7	4176	broad.mit.edu	37	chr7	99691888	99691888	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctctcgcctcatctccaCgtatgctgctgtgatgtagt	6	13	9	13	2	3	1	1	1	2	0	5	1	3	1	3	0	3	4	3	0	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:99691888C>T	uc003usw.1	-	13	2266	c.1756G>A	c.(1756-1758)GTG>ATG	p.V586M	MCM7_uc003usv.1_Missense_Mutation_p.V410M|MCM7_uc003usx.1_Missense_Mutation_p.V410M|uc003usy.1_5'Flank|MIR25_hsa-mir-25|MI0000082_5'Flank|uc003usz.1_5'Flank|MIR93_hsa-mir-93|MI0000095_5'Flank|uc003uta.1_5'Flank|MIR106B_hsa-mir-106b|MI0000734_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	586	Interaction with ATRIP.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	CTCATCTCCACGTATGCTGCT	0.577													11	60					0	0	0	0	T	99691888	T	T	99691888	3	4	84	1	0	0	0	0	1	0	0	0	9445	536	19	1	415	1	MCM7	7	99691888	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	16927732	99691888	59446775	154	16722											
AP4M1	9179	broad.mit.edu	37	chr7	99702922	99702922	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acagctctgtgaatctggacGaatttgagtctcatcgaatc	11	12	9	9	2	3	2	1	2	3	0	6	5	3	3	0	1	1	1	0	1	3	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:99702922G>A	uc003utb.3	+	10	995	c.787G>A	c.(787-789)GAA>AAA	p.E263K	AP4M1_uc011kjg.1_Missense_Mutation_p.E217K|AP4M1_uc010lgl.1_Missense_Mutation_p.E263K|AP4M1_uc003utc.3_Missense_Mutation_p.E270K|AP4M1_uc010lgm.2_Missense_Mutation_p.E135K|AP4M1_uc003utd.2_Missense_Mutation_p.E263K|AP4M1_uc011kjh.1_Missense_Mutation_p.E215K|AP4M1_uc003ute.3_Missense_Mutation_p.E38K|AP4M1_uc003utf.3_Missense_Mutation_p.E135K	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	263	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAATCTGGACGAATTTGAGTC	0.542													22	113					0	0	0	0	A	99702922	A	A	99702922	3	1	84	1	0	0	0	0	1	0	0	0	753	1059	37	1	825	1	AP4M1	7	99702922	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	11034	99702922	59435741	155	16723											
MUC17	140453	broad.mit.edu	37	chr7	100682580	100682580	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcatgccaatctcaactcCtagtgaagtaagtacttcat	13	11	6	11	0	2	1	2	1	1	0	4	1	3	1	2	0	4	3	2	0	6	4	rs146245479	by1000genomes	TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:100682580C>T	uc003uxp.1	+	3	7936	c.7883C>T	c.(7882-7884)CCT>CTT	p.P2628L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2628	Extracellular (Potential).|59 X approximate tandem repeats.|42.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ATCTCAACTCCTAGTGAAGTA	0.458													255	106					0	0	0	0	T	100682580	T	T	100682580	3	4	84	1	0	0	0	0	1	0	0	0	10027	681	24	4	7893	4	MUC17	7	100682580	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	979658	100682580	58456083	156	16724											
ARMC10	83787	broad.mit.edu	37	chr7	102738868	102738868	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggccatttagctgtgcaGcctactttcactgaaggttc	9	12	10	10	0	1	1	1	1	0	0	2	2	1	1	2	2	4	3	2	2	4	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:102738868G>T	uc003vaw.1	+	7	1292	c.900G>T	c.(898-900)CAG>CAT	p.Q300H	ARMC10_uc003vay.1_Missense_Mutation_p.Q241H|ARMC10_uc003vax.1_Missense_Mutation_p.Q265H|ARMC10_uc003vbb.1_Missense_Mutation_p.Q206H|ARMC10_uc011kli.1_Missense_Mutation_p.Q241H|ARMC10_uc010lis.1_Missense_Mutation_p.Q182H|ARMC10_uc003vba.1_RNA|ARMC10_uc003vaz.1_Missense_Mutation_p.Q178H	NM_031905	NP_114111	Q8N2F6	ARM10_HUMAN	SVH protein isoform a	300					regulation of growth	endoplasmic reticulum membrane|integral to membrane	binding			ovary(1)	1						TAGCTGTGCAGCCTACTTTCA	0.403													16	63					1.74807e-11	2.76995e-11	1	0	T	102738868	T	T	102738868	3	4	84	1	0	0	0	0	1	0	0	0	952	962	34	4	926	4	ARMC10	7	102738868	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2056288	102738868	56399795	157	16725											
FOXP2	93986	broad.mit.edu	37	chr7	114284743	114284743	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgttcttttgctacagctcGtcacatgaggagactggggc	7	12	13	9	1	2	2	1	1	1	1	3	3	2	2	0	3	3	3	0	3	1	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:114284743G>C	uc003vhb.2	+	8	1367	c.993G>C	c.(991-993)TCG>TCC	p.S331S	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Silent_p.S356S|FOXP2_uc003vha.2_Silent_p.S239S|FOXP2_uc011kmu.1_Silent_p.S348S|FOXP2_uc011kmv.1_Silent_p.S330S|FOXP2_uc010ljz.1_Silent_p.S239S|FOXP2_uc003vgx.2_Silent_p.S331S|FOXP2_uc003vhd.2_Silent_p.S331S|FOXP2_uc003vhc.2_Silent_p.S356S	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	331					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						GCTACAGCTCGTCACATGAGG	0.468													5	37					0	0	0	0	C	114284743	C	C	114284743	2	2	84	1	0	0	0	0	0	0	0	1	6061	1132	40	3		3	FOXP2	7	114284743	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	11545875	114284743	44853920	158	16726											
POT1	25913	broad.mit.edu	37	chr7	124475372	124475372	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgtataagaaatggtgctGaaaggtccaaaagttccagg	14	10	11	6	0	0	2	0	1	0	1	2	2	2	2	2	3	1	3	2	3	6	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:124475372G>A	uc003vlm.2	-	15	2067	c.1466C>T	c.(1465-1467)TCA>TTA	p.S489L	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.S358L|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	489					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						AAATGGTGCTGAAAGGTCCAA	0.289													13	71					0	0	0	0	A	124475372	A	A	124475372	3	1	84	1	0	0	0	0	1	0	0	0	12315	1294	45	2	458	2	POT1	7	124475372	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	10190629	124475372	34663291	159	16727											
OR2A2	442361	broad.mit.edu	37	chr7	143807030	143807030	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgattttggtggtgatgtccTatgataggtatgtggccatc	7	16	13	5	0	0	3	0	3	0	0	2	3	1	3	2	4	0	1	2	4	3	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:143807030T>A	uc011ktz.1	+	1	355	c.355T>A	c.(355-357)TAT>AAT	p.Y119N		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					GGTGATGTCCTATGATAGGTA	0.463													96	41					0	0	0	0	A	143807030	A	A	143807030	3	1	84	1	0	0	0	0	1	0	0	0	11031	1522	53	5	357	5	OR2A2	7	143807030	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	19331658	143807030	15331633	160	16728											
HTR5A	3361	broad.mit.edu	37	chr7	154862941	154862941	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgccgctggcagctaggtcGgaggctgtgccagctttgga	5	8	17	11	3	0	0	0	0	0	0	1	2	0	2	2	5	3	5	2	5	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr7:154862941G>T	uc003wlu.1	+	1	396	c.332G>T	c.(331-333)CGG>CTG	p.R111L	uc011kvt.1_Silent_p.R25R|uc003wlt.2_Silent_p.R25R	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	111	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CAGCTAGGTCGGAGGCTGTGC	0.667													12	30					1.5842e-08	2.36332e-08	1	0	T	154862941	T	T	154862941	3	4	84	1	0	0	0	0	1	0	0	0	7489	1116	39	3	334	3	HTR5A	7	154862941	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	11055911	154862941	4275722	161	16729											
PIWIL2	55124	broad.mit.edu	37	chr8	22167481	22167481	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attttctgtttagattgaagGacgtgttctgccaatggaaa	11	15	10	5	1	2	2	0	1	2	1	2	4	2	4	1	2	1	2	1	2	4	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:22167481G>T	uc003xbn.2	+	15	1842	c.1694G>T	c.(1693-1695)GGA>GTA	p.G565V	PIWIL2_uc011kzf.1_Missense_Mutation_p.G565V|PIWIL2_uc010ltv.2_Missense_Mutation_p.G565V	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	565					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		TAGATTGAAGGACGTGTTCTG	0.388													28	23					2.12542e-12	3.39321e-12	1	0	T	22167481	T	T	22167481	3	4	84	1	0	0	0	0	1	0	0	0	12013	1174	41	2	1748	2	PIWIL2	8	22167481	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08		22167481	124196541	162	16730											
PURG	29942	broad.mit.edu	37	chr8	30889770	30889770	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atatttcctattgtccctctCgatatagtctgttttcagga	8	18	6	9	1	3	0	1	0	2	0	6	2	5	1	2	1	0	1	2	1	4	8			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:30889770C>G	uc003xin.2	-	1	548	c.529G>C	c.(529-531)GAG>CAG	p.E177Q	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Missense_Mutation_p.E177Q	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	177	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		TTGTCCCTCTCGATATAGTCT	0.532													14	58					0	0	0	0	G	30889770	G	G	30889770	3	3	84	1	0	0	0	0	1	0	0	0	12894	893	31	3	627	3	PURG	8	30889770	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	8722289	30889770	115474252	163	16731			1	20		3	3	272	C		5.793484e-06
PURG	29942	broad.mit.edu	37	chr8	30889786	30889786	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctcgatatagtctgttttCaggacactgtgaggatgctc	8	14	10	9	1	3	1	1	1	2	0	5	4	3	3	0	2	1	2	0	2	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:30889786C>G	uc003xin.2	-	1	532	c.513G>C	c.(511-513)CTG>CTC	p.L171L	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Silent_p.L171L	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	171	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		AGTCTGTTTTCAGGACACTGT	0.527													15	74					0	0	0	0	G	30889786	G	G	30889786	2	3	84	1	0	0	0	0	0	0	0	1	12894	813	29	2		2	PURG	8	30889786	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	16	30889786	115474236	164	16732			1	20		3	3	272	C		5.793484e-06
PURG	29942	broad.mit.edu	37	chr8	30890041	30890041	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctatccagacttcggctatCtttaggaagcggccccggga	8	9	11	13	3	1	1	0	0	1	1	3	3	2	3	4	4	1	1	4	4	4	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:30890041C>G	uc003xin.2	-	1	277	c.258G>C	c.(256-258)AAG>AAC	p.K86N	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Missense_Mutation_p.K86N	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	86	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		CTTCGGCTATCTTTAGGAAGC	0.552													7	26					0	0	0	0	G	30890041	G	G	30890041	3	3	84	1	0	0	0	0	1	0	0	0	12894	912	32	2	898	2	PURG	8	30890041	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	255	30890041	115473981	165	16733			1	20		3	3	272	C		5.793484e-06
IKBKB	3551	broad.mit.edu	37	chr8	42171930	42171930	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttttcaagctctttaccctaCcccaataatcttaacaggta	12	14	3	12	0	3	0	1	0	2	0	3	0	3	0	3	1	4	2	3	1	7	8	rs150493359		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:42171930C>T	uc003xow.1	+	9	960	c.783C>T	c.(781-783)TAC>TAT	p.Y261Y	IKBKB_uc003xov.2_Silent_p.Y261Y|IKBKB_uc010lxh.1_Silent_p.Y156Y|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Silent_p.Y38Y|IKBKB_uc003xox.1_5'UTR|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Silent_p.Y259Y|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Silent_p.Y202Y	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	261	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	CTTTACCCTACCCCAATAATC	0.358													42	90					0	0	0	0	T	42171930	T	T	42171930	2	4	84	1	0	0	0	0	0	0	0	1	7650	518	18	4		4	IKBKB	8	42171930	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	11281889	42171930	104192092	166	16734											
ST18	9705	broad.mit.edu	37	chr8	53084518	53084518	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgctccagcaaacttaaattCcccttggccttttccaggtc	8	13	6	14	0	0	0	0	0	0	0	4	0	3	0	5	2	3	2	5	2	3	5	rs149814559		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:53084518C>T	uc003xqz.2	-	5	1059	c.903G>A	c.(901-903)GGG>GGA	p.G301G	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Silent_p.G266G|ST18_uc011lds.1_Silent_p.G206G|ST18_uc003xra.2_Silent_p.G301G|ST18_uc003xrb.2_Silent_p.G301G	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	301						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AACTTAAATTCCCCTTGGCCT	0.527													22	40					0	0	0	0	T	53084518	T	T	53084518	2	4	84	1	0	0	0	0	0	0	0	1	15278	842	30	2		2	ST18	8	53084518	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	10912588	53084518	93279504	167	16735											
CHD7	55636	broad.mit.edu	37	chr8	61769309	61769309	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctccaagcaggcctttcGcgcacacccacaaggcatct	9	7	8	17	2	1	0	0	0	1	0	3	0	2	0	3	2	2	4	3	2	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:61769309G>A	uc003xue.2	+	34	7947	c.7470G>A	c.(7468-7470)TCG>TCA	p.S2490S		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2490					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CAGGCCTTTCGCGCACACCCA	0.483													31	165					0	0	0	0	A	61769309	A	A	61769309	2	1	84	1	0	0	0	0	0	0	0	1	3345	1074	38	1		1	CHD7	8	61769309	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	8684791	61769309	84594713	168	16736											
NBN	4683	broad.mit.edu	37	chr8	90960066	90960066	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcacagatatttctttagCtgaccatagtgagtcttcct	9	16	6	10	0	3	3	1	2	3	1	5	3	4	3	2	0	1	1	2	0	3	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:90960066C>G	uc003yej.1	-	12	2010	c.1900G>C	c.(1900-1902)GCT>CCT	p.A634P	NBN_uc003yei.1_Missense_Mutation_p.A552P|NBN_uc011lgb.1_Missense_Mutation_p.A634P	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	634					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			ATTTCTTTAGCTGACCATAGT	0.303								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				2	6					0	0	0	0	G	90960066	G	G	90960066	3	3	84	1	0	0	0	0	1	0	0	0	10244	797	28	4	384	4	NBN	8	90960066	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	29190757	90960066	55403956	169	16737											
KCNS2	3788	broad.mit.edu	37	chr8	99440930	99440930	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgcctggttcacatttgaGctggtggccaggtttgctgt	5	15	13	8	0	1	1	1	1	0	0	1	1	1	1	2	4	3	4	2	4	0	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:99440930G>T	uc003yin.2	+	2	1073	c.723G>T	c.(721-723)GAG>GAT	p.E241D		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	241	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			TCACATTTGAGCTGGTGGCCA	0.532													49	66					2.64894e-19	4.62295e-19	1	0	T	99440930	T	T	99440930	3	4	84	1	0	0	0	0	1	0	0	0	8128	962	34	4	725	4	KCNS2	8	99440930	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	8480864	99440930	46923092	170	16738											
CSMD3	114788	broad.mit.edu	37	chr8	114111143	114111144	+	Nonsense_Mutation	DNP	GG	TT	TT																															tcattaggaaaactagggctGgatatgatgccactggatcc																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:114111143_114111144GG>TT	uc003ynu.2	-	5	917_918	c.758_759CC>AA	c.(757-759)TCC>TAA	p.S253*	CSMD3_uc003ynt.2_Nonsense_Mutation_p.S213*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.S253*|CSMD3_uc010mcx.1_Nonsense_Mutation_p.S253*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	253	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AACTAGGGCTGGATATGATGCC	0.381										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	34					0	0	0	0	TT	114111144	TT	TT	114111143	4	4	84	1	0	0	0	0	0	1	0	0	3963	1335	47	4	10632	4	CSMD3	8	114111143	Nonsense_Mutation	DNP	GG	TCGA-CN-6992-01A-11D-1912-08	14670213	114111143	32252879	171	16739											
SNTB1	6641	broad.mit.edu	37	chr8	121587411	121587411	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatagattaaaaggtcttTctcagtcagcacaaccaggg	13	10	9	9	0	4	1	3	0	2	1	5	1	4	1	1	2	2	1	1	2	4	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:121587411T>C	uc010mdg.2	-	4	1277	c.1051A>G	c.(1051-1053)AAA>GAA	p.K351E	SNTB1_uc003ype.2_Missense_Mutation_p.K351E	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	351	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			AAAAGGTCTTTCTCAGTCAGC	0.512													55	99					0	0	0	0	C	121587411	C	C	121587411	3	2	84	1	0	0	0	0	1	0	0	0	14936	1792	62	5	581	5	SNTB1	8	121587411	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	7476268	121587411	24776611	172	16740											
WISP1	8840	broad.mit.edu	37	chr8	134225121	134225121	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgcaggccctctctccagcCcctacgaccatggactttac	7	8	7	19	2	1	0	0	0	1	0	3	2	2	1	6	2	3	1	6	2	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:134225121C>A	uc003yub.2	+	2	160	c.84C>A	c.(82-84)GCC>GCA	p.A28A	WISP1_uc003yuc.2_Silent_p.A28A|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Silent_p.A28A|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_5'Flank	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	28					cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			TCTCTCCAGCCCCTACGACCA	0.647													7	9					8.12818e-05	0.000114297	1	0	A	134225121	A	A	134225121	2	1	84	1	0	0	0	0	0	0	0	1	17440	610	22	4		4	WISP1	8	134225121	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	12637710	134225121	12138901	173	16741											
FAM135B	51059	broad.mit.edu	37	chr8	139151264	139151264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttggtagaggaaacatttgCgcaaatcagcattatccctg	12	11	10	8	1	1	1	1	0	0	1	2	2	2	2	1	2	3	4	1	2	4	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:139151264C>T	uc003yuy.2	-	18	4037	c.3866G>A	c.(3865-3867)CGC>CAC	p.R1289H	FAM135B_uc003yux.2_Missense_Mutation_p.R1190H|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1289										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GAAACATTTGCGCAAATCAGC	0.423										HNSCC(54;0.14)			18	56					0	0	0	0	T	139151264	T	T	139151264	3	4	84	1	0	0	0	0	1	0	0	0	5477	768	27	1	366	1	FAM135B	8	139151264	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	4926143	139151264	7212758	174	16742											
COL22A1	169044	broad.mit.edu	37	chr8	139691866	139691866	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatcttcactgaccttaacAcattgccctcccagtgcaca	11	10	5	15	0	2	2	1	1	1	1	3	2	3	2	3	0	3	1	3	0	1	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:139691866A>T	uc003yvd.2	-	40	3513	c.3066T>A	c.(3064-3066)TGT>TGA	p.C1022*	COL22A1_uc011ljo.1_Intron	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1022	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TGACCTTAACACATTGCCCTC	0.348										HNSCC(7;0.00092)			24	51					0	0	0	0	T	139691866	T	T	139691866	4	4	84	1	0	0	0	0	0	1	0	0	3696	157	6	5	1918	5	COL22A1	8	139691866	Nonsense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	540602	139691866	6672156	175	16743											
EIF2C2	27161	broad.mit.edu	37	chr8	141561467	141561467	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atggcccacaccttgatctcGatgcccgtgtggaactgctt	7	11	10	13	2	1	1	0	1	1	0	2	3	1	2	3	2	3	1	3	2	1	2	rs142051728		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:141561467G>A	uc003yvn.2	-	11	1378	c.1338C>T	c.(1336-1338)ATC>ATT	p.I446I	EIF2C2_uc010men.2_Silent_p.I369I|EIF2C2_uc010meo.2_Silent_p.I446I	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	446					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			CCTTGATCTCGATGCCCGTGT	0.592													40	65					0	0	0	0	A	141561467	A	A	141561467	2	1	84	1	0	0	0	0	0	0	0	1	5028	1048	37	1		1	EIF2C2	8	141561467	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1869601	141561467	4802555	176	16744											
CYP11B1	1584	broad.mit.edu	37	chr8	143961004	143961004	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctttacctgaaaatgggccCtagttcctggaaggtctggt	8	12	12	9	0	1	1	0	1	1	0	2	2	2	2	3	4	1	2	3	4	5	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:143961004C>G	uc003yxi.2	-	1	233	c.226G>C	c.(226-228)GGG>CGG	p.G76R	CYP11B1_uc003yxj.2_Missense_Mutation_p.G76R|CYP11B1_uc010mey.2_Missense_Mutation_p.G76R	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	76					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	AAAATGGGCCCTAGTTCCTGG	0.632									Familial_Hyperaldosteronism_type_I				31	69					0	0	0	0	G	143961004	G	G	143961004	3	3	84	1	0	0	0	0	1	0	0	0	4162	681	24	4	1321	4	CYP11B1	8	143961004	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2399537	143961004	2403018	177	16745											
TOP1MT	116447	broad.mit.edu	37	chr8	144403486	144403486	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagctggacgtgctccacgCggagggaacagcagcccacg	9	3	15	14	4	0	0	0	0	0	0	1	3	1	3	2	3	5	4	2	3	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:144403486C>A	uc003yxz.2	-	8	1050	c.1031G>T	c.(1030-1032)CGC>CTC	p.R344L	TOP1MT_uc011lkd.1_Missense_Mutation_p.R246L|TOP1MT_uc011lke.1_Missense_Mutation_p.R246L|TOP1MT_uc010mfb.2_Missense_Mutation_p.R246L|TOP1MT_uc011lkf.1_Missense_Mutation_p.R139L|TOP1MT_uc010mfd.1_Missense_Mutation_p.R139L	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	344					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	GTGCTCCACGCGGAGGGAACA	0.607													29	33					3.99451e-17	6.73149e-17	1	0	A	144403486	A	A	144403486	3	1	84	1	0	0	0	0	1	0	0	0	16431	768	27	3	802	3	TOP1MT	8	144403486	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	442482	144403486	1960536	178	16746											
PLEC	5339	broad.mit.edu	37	chr8	144992693	144992693	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acggtagccggtgaccgcccGctcagccgagagcaggcggt	7	4	16	14	6	1	2	1	1	0	1	1	3	1	2	4	4	3	3	4	4	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:144992693G>A	uc003zaf.1	-	32	11877	c.11707C>T	c.(11707-11709)CGG>TGG	p.R3903W	PLEC_uc003zab.1_Missense_Mutation_p.R3766W|PLEC_uc003zac.1_Missense_Mutation_p.R3770W|PLEC_uc003zad.2_Missense_Mutation_p.R3766W|PLEC_uc003zae.1_Missense_Mutation_p.R3734W|PLEC_uc003zag.1_Missense_Mutation_p.R3744W|PLEC_uc003zah.2_Missense_Mutation_p.R3752W|PLEC_uc003zaj.2_Missense_Mutation_p.R3793W	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3903	Globular 2.|Plectin 19.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTGACCGCCCGCTCAGCCGAG	0.677													7	18					0	0	0	0	A	144992693	A	A	144992693	3	1	84	1	0	0	0	0	1	0	0	0	12107	1086	38	1	2351	1	PLEC	8	144992693	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	589207	144992693	1371329	179	16747											
PLEC	5339	broad.mit.edu	37	chr8	144996154	144996154	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgaggcagtgacctcctctGagtgcgccagcgcggcccgg	5	5	16	15	5	1	2	0	2	1	0	2	3	2	2	4	3	2	1	4	3	0	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:144996154G>C	uc003zaf.1	-	32	8416	c.8246C>G	c.(8245-8247)TCA>TGA	p.S2749*	PLEC_uc003zab.1_Nonsense_Mutation_p.S2612*|PLEC_uc003zac.1_Nonsense_Mutation_p.S2616*|PLEC_uc003zad.2_Nonsense_Mutation_p.S2612*|PLEC_uc003zae.1_Nonsense_Mutation_p.S2580*|PLEC_uc003zag.1_Nonsense_Mutation_p.S2590*|PLEC_uc003zah.2_Nonsense_Mutation_p.S2598*|PLEC_uc003zaj.2_Nonsense_Mutation_p.S2639*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2749	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GACCTCCTCTGAGTGCGCCAG	0.632													3	34					0	0	0	0	C	144996154	C	C	144996154	4	2	84	1	0	0	0	0	0	1	0	0	12107	1294	45	2	5812	2	PLEC	8	144996154	Nonsense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3461	144996154	1367868	180	16748											
GPR172A	79581	broad.mit.edu	37	chr8	145583729	145583729	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttccttgagcgttttcccGccagcaccttcttctgggca	5	13	8	15	2	2	1	0	1	2	0	4	1	4	1	4	1	2	3	4	1	0	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:145583729G>A	uc003zcc.1	+	3	734	c.577G>A	c.(577-579)GCC>ACC	p.A193T	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.A193T|GPR172A_uc003zce.1_Missense_Mutation_p.A193T|GPR172A_uc010mfy.1_Missense_Mutation_p.A193T|GPR172A_uc003zcf.1_Missense_Mutation_p.A193T|GPR172A_uc011llc.1_Missense_Mutation_p.A105T	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	193						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			GCGTTTTCCCGCCAGCACCTT	0.662													33	64					0	0	0	0	A	145583729	A	A	145583729	3	1	84	1	0	0	0	0	1	0	0	0	6707	1087	38	1	583	1	GPR172A	8	145583729	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	587575	145583729	780293	181	16749											
CPSF1	29894	broad.mit.edu	37	chr8	145626157	145626157	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgatgatgttgagcagcttCtcgtctagggcccgcacgtc	6	11	12	12	4	2	2	0	2	2	0	5	3	2	2	1	1	2	4	1	1	1	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr8:145626157C>T	uc003zcj.2	-	7	669	c.594G>A	c.(592-594)GAG>GAA	p.E198E	CPSF1_uc003zck.1_Silent_p.E120E|CPSF1_uc011lle.1_Silent_p.E198E|MIR1234_hsa-mir-1234|MI0006324_5'Flank|CPSF1_uc011llf.1_Silent_p.E198E	NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	198					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			TGAGCAGCTTCTCGTCTAGGG	0.637													9	44					0	0	0	0	T	145626157	T	T	145626157	2	4	84	1	0	0	0	0	0	0	0	1	3839	912	32	2		2	CPSF1	8	145626157	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	42428	145626157	737865	182	16750											
SMARCA2	6595	broad.mit.edu	37	chr9	2123782	2123782	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aacggaagccccgtttaatgGaggaggatgagctgccctcc	10	7	13	11	2	0	1	0	1	0	0	1	5	1	5	4	4	4	2	4	4	3	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:2123782G>A	uc003zhc.2	+	27	3925	c.3826G>A	c.(3826-3828)GAG>AAG	p.E1276K	SMARCA2_uc003zhd.2_Missense_Mutation_p.E1276K|SMARCA2_uc010mha.2_Missense_Mutation_p.E1209K	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1276					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CCGTTTAATGGAGGAGGATGA	0.547													7	36					0	0	0	0	A	2123782	A	A	2123782	3	1	84	1	0	0	0	0	1	0	0	0	14833	1175	41	2	3928	2	SMARCA2	9	2123782	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08		2123782	139089649	183	16751											
TMEM215	401498	broad.mit.edu	37	chr9	32784253	32784253	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtgtcttcctcgtctttggTttcatgttcaccgtctctgg	3	18	9	11	2	5	0	2	0	3	0	8	0	6	0	2	2	0	2	2	2	0	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:32784253T>A	uc003zri.3	+	2	437	c.72T>A	c.(70-72)GGT>GGA	p.G24G		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	24	Helical; (Potential).					integral to membrane					0						TCGTCTTTGGTTTCATGTTCA	0.582													25	16					0	0	0	0	A	32784253	A	A	32784253	2	1	84	1	0	0	0	0	0	0	0	1	16204	1712	60	5		5	TMEM215	9	32784253	Silent	SNP	T	TCGA-CN-6992-01A-11D-1912-08	30660471	32784253	108429178	184	16752											
ZBTB5	9925	broad.mit.edu	37	chr9	37441584	37441584	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaccactctcatgtgctccTtctcaccaaggccaacctca	9	9	4	19	0	3	0	3	0	2	0	6	0	4	0	6	1	2	1	6	1	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:37441584T>C	uc003zzx.2	-	2	1165	c.965A>G	c.(964-966)AAG>AGG	p.K322R		NM_014872	NP_055687	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)		CATGTGCTCCTTCTCACCAAG	0.512													3	88					0	0	0	0	C	37441584	C	C	37441584	3	2	84	1	0	0	0	0	1	0	0	0	17618	1609	56	5	1072	5	ZBTB5	9	37441584	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	4657331	37441584	103771847	185	16753											
MCART1	92014	broad.mit.edu	37	chr9	37888027	37888027	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaagaatgggcaccaagcctCgataatactctccaattcca	15	8	6	12	1	1	1	0	0	1	1	4	2	2	1	4	1	2	1	4	1	6	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:37888027C>T	uc004aau.2	-	3	1265	c.521G>A	c.(520-522)CGA>CAA	p.R174Q	MCART1_uc004aar.1_Intron|MCART1_uc004aaq.1_Intron|uc004aat.1_5'Flank|MCART1_uc004aav.2_Missense_Mutation_p.R174Q	NM_033412	NP_219480	Q9H1U9	MCAR1_HUMAN	mitochondrial carrier triple repeat 1	174	Solcar 2.				transport	integral to membrane|mitochondrial inner membrane				ovary(2)|breast(1)	3				GBM - Glioblastoma multiforme(29;0.00559)|Lung(182;0.0422)		CACCAAGCCTCGATAATACTC	0.463													20	61					0	0	0	0	T	37888027	T	T	37888027	3	4	84	1	0	0	0	0	1	0	0	0	9422	884	31	1	376	1	MCART1	9	37888027	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	446443	37888027	103325404	186	16754											
FAM189A2	9413	broad.mit.edu	37	chr9	72006633	72006633	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cacaccttcacaccagcgggGaggccccgagccgagaggag	10	2	14	15	3	1	1	1	0	0	1	1	5	1	3	5	4	2	0	5	4	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:72006633G>C	uc010mon.1	+	11	1370	c.1266G>C	c.(1264-1266)GGG>GGC	p.G422G	FAM189A2_uc004ahg.2_Silent_p.G422G|FAM189A2_uc010moo.1_Missense_Mutation_p.E160Q	NM_001127608	NP_001121080	Q15884	F1892_HUMAN	chromosome 9 open reading frame 61 precursor	422						integral to membrane					0						CACCAGCGGGGAGGCCCCGAG	0.672													3	25					0	0	0	0	C	72006633	C	C	72006633	2	2	84	1	0	0	0	0	0	0	0	1	5544	1161	41	2		2	FAM189A2	9	72006633	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	34118606	72006633	69206798	187	16755											
FLJ46321	389763	broad.mit.edu	37	chr9	84603737	84603737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctgagctattcagaccatgGagaatatcctctgttttctg	9	14	9	9	0	3	3	1	1	2	2	4	4	4	3	2	1	1	3	2	1	3	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:84603737G>A	uc004amn.2	+	1	51	c.4G>A	c.(4-6)GAG>AAG	p.E2K		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	2						integral to membrane					0						TCAGACCATGGAGAATATCCT	0.502													28	34					0	0	0	0	A	84603737	A	A	84603737	3	1	84	1	0	0	0	0	1	0	0	0	5964	1175	41	2	6	2	FLJ46321	9	84603737	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	12597104	84603737	56609694	188	16756											
DAPK1	1612	broad.mit.edu	37	chr9	90264868	90264868	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cccctgcactgtgctgcttgGcacggctattactctgtggc	4	12	11	14	1	1	0	0	0	1	0	1	0	1	0	2	3	4	5	2	3	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:90264868G>A	uc004apc.2	+	16	1599	c.1461G>A	c.(1459-1461)TGG>TGA	p.W487*	DAPK1_uc004ape.2_Nonsense_Mutation_p.W487*|DAPK1_uc004apd.2_Nonsense_Mutation_p.W487*|DAPK1_uc011ltg.1_Nonsense_Mutation_p.W487*|DAPK1_uc011lth.1_Nonsense_Mutation_p.W224*|DAPK1_uc004apf.1_Nonsense_Mutation_p.W41*	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	487	ANK 4.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						GTGCTGCTTGGCACGGCTATT	0.522									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				18	42					0	0	0	0	A	90264868	A	A	90264868	4	1	84	1	0	0	0	0	0	1	0	0	4252	1212	42	4	1519	4	DAPK1	9	90264868	Nonsense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	5661131	90264868	50948563	189	16757											
PAPPA	5069	broad.mit.edu	37	chr9	118974201	118974201	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actccttacaacaacttcatGagctatgcaggtagggccct	11	10	8	12	0	1	1	1	1	0	0	2	1	2	1	2	2	5	3	2	2	5	4	rs144109251		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:118974201G>T	uc004bjn.2	+	4	2289	c.1908G>T	c.(1906-1908)ATG>ATT	p.M636I	PAPPA_uc011lxp.1_Intron|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	636					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						ACAACTTCATGAGCTATGCAG	0.512													75	115					5.44642e-36	1.01741e-35	1	0	T	118974201	T	T	118974201	3	4	84	1	0	0	0	0	1	0	0	0	11486	1290	45	2	1922	2	PAPPA	9	118974201	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	28709333	118974201	22239230	190	16758											
OR1L6	392390	broad.mit.edu	37	chr9	125512877	125512877	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacctcactgcagtagccCttttctatgggagtattatt	8	14	7	12	0	2	0	1	0	1	0	2	1	2	1	3	1	2	3	3	1	4	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:125512877C>G	uc011lzc.1	+	1	859	c.859C>G	c.(859-861)CTT>GTT	p.L287V		NM_001004453	NP_001004453	Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L,	287	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCAGTAGCCCTTTTCTATGG	0.517													20	57					0	0	0	0	G	125512877	G	G	125512877	3	3	84	1	0	0	0	0	1	0	0	0	11020	681	24	4	753	4	OR1L6	9	125512877	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	6538676	125512877	15700554	191	16759											
LAMC3	10319	broad.mit.edu	37	chr9	133901891	133901891	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctctgagttcagcgacatctCcccgctgagtggcggcaacg	7	8	12	14	4	3	2	1	2	2	0	4	3	3	2	2	2	2	3	2	2	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:133901891C>T	uc004caa.1	+	2	691	c.593C>T	c.(592-594)TCC>TTC	p.S198F		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	198	Laminin N-terminal.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		AGCGACATCTCCCCGCTGAGT	0.701													9	22					0	0	0	0	T	133901891	T	T	133901891	3	4	84	1	0	0	0	0	1	0	0	0	8656	855	30	2	599	2	LAMC3	9	133901891	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	8389014	133901891	7311540	192	16760											
EHMT1	79813	broad.mit.edu	37	chr9	140728957	140728957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcttcagcacccgcctgatcGaggccggcgagcagctcggg	6	6	14	15	5	2	1	1	1	1	0	4	3	2	1	3	3	3	3	3	3	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr9:140728957G>A	uc011mfc.1	+	26	3734	c.3697G>A	c.(3697-3699)GAG>AAG	p.E1233K	EHMT1_uc004coe.2_Missense_Mutation_p.E138K	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1233	SET.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CCGCCTGATCGAGGCCGGCGA	0.697													6	32					0	0	0	0	A	140728957	A	A	140728957	3	1	84	1	0	0	0	0	1	0	0	0	5005	1059	37	1	3848	1	EHMT1	9	140728957	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	6827066	140728957	484474	193	16761											
PRKCQ	5588	broad.mit.edu	37	chr10	6521108	6521108	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgaaaaattgattggttttcTtgaattctgccaggaagacc	12	13	9	7	1	2	3	0	2	2	1	2	5	2	4	2	2	1	1	2	2	4	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:6521108T>A	uc001ijj.1	-	12	1274	c.1199A>T	c.(1198-1200)AAG>ATG	p.K400M	PRKCQ_uc009xim.1_Missense_Mutation_p.K400M|PRKCQ_uc001iji.1_Missense_Mutation_p.K433M|PRKCQ_uc009xin.1_Missense_Mutation_p.K364M|PRKCQ_uc010qax.1_Missense_Mutation_p.K275M	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	400	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						ATTGGTTTTCTTGAATTCTGC	0.388													18	34					0	0	0	0	A	6521108	A	A	6521108	3	1	84	1	0	0	0	0	1	0	0	0	12577	1609	56	5	949	5	PRKCQ	10	6521108	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08		6521108	129013639	194	16762											
SFMBT2	57713	broad.mit.edu	37	chr10	7239525	7239525	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttacctctttaagaaccagCacgcatttgcccggtcccac	9	11	6	15	2	1	1	0	0	1	1	2	1	2	1	4	1	4	2	4	1	3	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:7239525C>G	uc009xio.1	-	15	1774	c.1683G>C	c.(1681-1683)GTG>GTC	p.V561V	SFMBT2_uc001ijn.1_Silent_p.V561V|SFMBT2_uc010qay.1_Intron	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	561					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						TAAGAACCAGCACGCATTTGC	0.483													31	58					0	0	0	0	G	7239525	G	G	7239525	2	3	84	1	0	0	0	0	0	0	0	1	14223	697	25	4		4	SFMBT2	10	7239525	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	718417	7239525	128295222	195	16763											
GATA3	2625	broad.mit.edu	37	chr10	8100668	8100668	+	Frame_Shift_Del	DEL	G	-	-																															ctgggtggagcctcctcgtcGacccaccaccccatcaccac																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:8100668delG	uc001ika.2	+	3	1199	c.642delG	c.(640-642)TCGfs	p.S214fs	GATA3_uc001ijz.2_Frame_Shift_Del_p.S214fs	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	214					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						CCTCCTCGTCGACCCACCACC	0.682			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						---	---	---								-	8100668	-	-	8100668	7	5	84	1	0	1	0	1	0	0	0	0	6290	1045	37	0	648	0	GATA3	10	8100668	Frame_Shift_Del	DEL	G	TCGA-CN-6992-01A-11D-1912-08	861143	8100668	127434079	196	16764											
MCM10	55388	broad.mit.edu	37	chr10	13222601	13222601	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggttacgccacagagtgtGaatagtgtaagccattgtat	13	11	11	6	1	0	2	0	1	0	1	0	2	0	2	2	1	2	3	2	1	6	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:13222601G>T	uc001ima.2	+	7	1028	c.927G>T	c.(925-927)GTG>GTT	p.V309V	MCM10_uc001imb.2_Silent_p.V308V|MCM10_uc001imc.2_Silent_p.V308V	NM_182751	NP_877428	Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	309					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						CACAGAGTGTGAATAGTGTAA	0.408													35	77					8.73648e-17	1.45304e-16	1	0	T	13222601	T	T	13222601	2	4	84	1	0	0	0	0	0	0	0	1	9438	1277	45	2		2	MCM10	10	13222601	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	5121933	13222601	122312146	197	16765											
TRDMT1	1787	broad.mit.edu	37	chr10	17199734	17199734	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttttattttctacatccattGcatatttttgtggatgtaca	9	21	5	6	0	1	0	0	0	1	0	2	1	2	1	1	1	3	2	1	1	4	10			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:17199734G>T	uc001iop.2	-	8	641	c.593C>A	c.(592-594)GCA>GAA	p.A198E	TRDMT1_uc001ioq.2_Missense_Mutation_p.A174E|TRDMT1_uc001ior.2_Missense_Mutation_p.A152E|TRDMT1_uc001ios.2_Missense_Mutation_p.A127E|TRDMT1_uc009xjt.2_Missense_Mutation_p.A117E|TRDMT1_uc010qcc.1_Missense_Mutation_p.A127E|TRDMT1_uc010qcd.1_Missense_Mutation_p.A75E	NM_004412	NP_004403	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1 isoform	198					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			ovary(1)	1						TACATCCATTGCATATTTTTG	0.318													14	18					4.3838e-07	6.39012e-07	1	0	T	17199734	T	T	17199734	3	4	84	1	0	0	0	0	1	0	0	0	16534	1319	46	4	598	4	TRDMT1	10	17199734	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3977133	17199734	118335013	198	16766											
CACNB2	783	broad.mit.edu	37	chr10	18807304	18807304	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgatgtggtaccttccatgCgaccagtggtcctagtgggc	7	11	13	10	1	0	1	0	1	0	0	2	2	2	1	4	3	2	1	4	3	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:18807304C>A	uc001ipr.2	+	8	904	c.844C>A	c.(844-846)CGA>AGA	p.R282R	CACNB2_uc009xjz.1_Intron|CACNB2_uc001ips.2_Silent_p.R258R|CACNB2_uc001ipt.2_Silent_p.R244R|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Silent_p.R254R|CACNB2_uc001ipv.2_Silent_p.R230R|CACNB2_uc009xka.1_Silent_p.R216R|CACNB2_uc001ipw.2_Silent_p.R189R|CACNB2_uc001ipx.2_Silent_p.R227R|CACNB2_uc009xkb.1_3'UTR|CACNB2_uc010qcm.1_Silent_p.R228R|CACNB2_uc001ipz.2_Silent_p.R204R|CACNB2_uc001ipy.2_Silent_p.R228R|CACNB2_uc010qcn.1_Silent_p.R196R|CACNB2_uc010qco.1_Silent_p.R196R|CACNB2_uc001iqa.2_Silent_p.R234R|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	282					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ACCTTCCATGCGACCAGTGGT	0.502													44	91					3.76525e-18	6.43019e-18	1	0	A	18807304	A	A	18807304	2	1	84	1	0	0	0	0	0	0	0	1	2565	760	27	3		3	CACNB2	10	18807304	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1607570	18807304	116727443	199	16767											
ANKRD30A	91074	broad.mit.edu	37	chr10	37430667	37430667	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaacatctgcaggaacacCtgatgaggctgcacccttgg	11	7	12	11	0	1	2	0	2	1	0	1	4	1	4	2	4	4	3	2	4	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:37430667C>A	uc001iza.1	+	7	773	c.674C>A	c.(673-675)CCT>CAT	p.P225H		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	281						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GCAGGAACACCTGATGAGGCT	0.363													10	29					9.70103e-10	1.48191e-09	1	0	A	37430667	A	A	37430667	3	1	84	1	0	0	0	0	1	0	0	0	658	681	24	4	700	4	ANKRD30A	10	37430667	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	18623363	37430667	98104080	200	16768											
OR13A1	79290	broad.mit.edu	37	chr10	45799384	45799384	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcagccacacggctgtggCcagcccgctgcagaacacct	9	4	12	16	2	0	1	0	0	0	1	0	2	0	1	4	2	5	4	4	2	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:45799384C>A	uc001jcc.1	-	4	796	c.487G>T	c.(487-489)GCC>TCC	p.A163S	OR13A1_uc001jcd.1_Missense_Mutation_p.A159S	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	163	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACGGCTGTGGCCAGCCCGCTG	0.597													18	40					1.87028e-06	2.70766e-06	1	0	A	45799384	A	A	45799384	3	1	84	1	0	0	0	0	1	0	0	0	10987	739	26	4	503	4	OR13A1	10	45799384	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	8368717	45799384	89735363	201	16769											
FAM21B	55747	broad.mit.edu	37	chr10	47915915	47915915	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaaatctcaagccctcatCagaaacaaagactcaaaaag	21	5	4	11	0	4	2	4	0	1	2	5	2	4	2	1	0	2	0	1	0	7	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:47915915C>A	uc009xni.2	+	15	1322	c.1322C>A	c.(1321-1323)TCA>TAA	p.S441*	FAM21B_uc001jep.3_Nonsense_Mutation_p.S336*	NM_018232	NP_060702	Q5SNT6	FA21B_HUMAN	hypothetical protein LOC55747	441					retrograde transport, endosome to Golgi	early endosome membrane|WASH complex				ovary(1)	1						AAGCCCTCATCAGAAACAAAG	0.403													11	130					7.93312e-07	1.15374e-06	1	0	A	47915915	A	A	47915915	4	1	84	1	0	0	0	0	0	1	0	0	5569	838	29	2	1380	2	FAM21B	10	47915915	Nonsense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2116531	47915915	87618832	202	16770											
SLC18A3	6572	broad.mit.edu	37	chr10	50819675	50819675	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattgccgtggtggccggcGcgctcaccacctgtaacatt	7	9	11	14	4	1	0	1	0	0	0	1	0	1	0	4	3	2	2	4	3	1	3	rs149097990		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:50819675G>A	uc001jhw.2	+	1	1329	c.889G>A	c.(889-891)GCG>ACG	p.A297T	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	297	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GGTGGCCGGCGCGCTCACCAC	0.642													25	44					0	0	0	0	A	50819675	A	A	50819675	3	1	84	1	0	0	0	0	1	0	0	0	14492	1087	38	1	891	1	SLC18A3	10	50819675	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2903760	50819675	84715072	203	16771											
A1CF	29974	broad.mit.edu	37	chr10	52619639	52619639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcgctggaccagtgcgCggagggctgcttccttctga	4	10	15	12	3	1	1	0	1	1	0	2	3	2	3	2	3	3	3	2	3	0	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:52619639C>T	uc001jjj.2	-	3	250	c.62G>A	c.(61-63)CGC>CAC	p.R21H	A1CF_uc010qhn.1_5'UTR|A1CF_uc001jji.2_Missense_Mutation_p.R21H|A1CF_uc001jjh.2_5'UTR|A1CF_uc010qho.1_5'UTR|A1CF_uc009xov.2_Missense_Mutation_p.R21H|A1CF_uc001jjk.1_Missense_Mutation_p.R21H	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	21					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						GACCAGTGCGCGGAGGGCTGC	0.478													21	34					0	0	0	0	T	52619639	T	T	52619639	3	4	84	1	0	0	0	0	1	0	0	0	2	768	27	1	1893	1	A1CF	10	52619639	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1799964	52619639	82915108	204	16772											
TMEM26	219623	broad.mit.edu	37	chr10	63212740	63212740	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgcaagcagccagtaccgcgGctccttcttcacctcggtca	7	8	9	17	4	3	0	2	0	1	0	5	0	4	0	4	2	3	4	4	2	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:63212740G>T	uc001jlo.2	-	1	469	c.100C>A	c.(100-102)CCG>ACG	p.P34T	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlq.2_RNA|uc001jlr.2_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	34						integral to membrane					0	Prostate(12;0.0112)					CAGTACCGCGGCTCCTTCTTC	0.607													32	64					1.99505e-19	3.49134e-19	1	0	T	63212740	T	T	63212740	3	4	84	1	0	0	0	0	1	0	0	0	16217	1203	42	4	1030	4	TMEM26	10	63212740	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	10593101	63212740	72322007	205	16773											
MYPN	84665	broad.mit.edu	37	chr10	69935118	69935118	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaaaaatacaaagtctcCtcaaccagtgaatgatgata	19	8	7	7	0	2	4	1	3	1	1	3	5	2	4	2	0	2	0	2	0	8	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:69935118C>T	uc001jnm.3	+	13	2788	c.2603C>T	c.(2602-2604)CCT>CTT	p.P868L	MYPN_uc001jnn.3_Missense_Mutation_p.P593L|MYPN_uc001jno.3_Missense_Mutation_p.P868L|MYPN_uc009xpt.2_Missense_Mutation_p.P868L|MYPN_uc010qit.1_Missense_Mutation_p.P574L|MYPN_uc010qiu.1_Intron	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	868						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						ACAAAGTCTCCTCAACCAGTG	0.433													14	24					0	0	0	0	T	69935118	T	T	69935118	3	4	84	1	0	0	0	0	1	0	0	0	10151	681	24	4	2645	4	MYPN	10	69935118	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	6722378	69935118	65599629	206	16774											
SLC25A16	8034	broad.mit.edu	37	chr10	70246946	70246946	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttcctaattgcattcgcCgacgagtcacatcaaatggg	11	10	9	11	3	2	0	2	0	0	0	4	2	3	0	2	1	1	2	2	1	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:70246946C>T	uc001joi.2	-	8	1249	c.797G>A	c.(796-798)CGG>CAG	p.R266Q	SLC25A16_uc010qix.1_Missense_Mutation_p.R132Q|SLC25A16_uc010qiy.1_Missense_Mutation_p.R168Q|SLC25A16_uc001joj.2_Missense_Mutation_p.R168Q	NM_152707	NP_689920	P16260	GDC_HUMAN	solute carrier family 25, member 16	266	Solcar 3.				coenzyme biosynthetic process|pantothenate metabolic process	integral to membrane|mitochondrial inner membrane	binding|solute:solute antiporter activity				0						TTGCATTCGCCGACGAGTCAC	0.333													52	125					0	0	0	0	T	70246946	T	T	70246946	3	4	84	1	0	0	0	0	1	0	0	0	14542	652	23	1	209	1	SLC25A16	10	70246946	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	311828	70246946	65287801	207	16775											
SAR1A	56681	broad.mit.edu	37	chr10	71913632	71913632	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataaagcccaaatatctcacGgagtttttcttcactgattg	12	14	6	9	1	3	1	2	1	2	0	4	2	3	2	1	1	1	1	1	1	4	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:71913632G>A	uc010qjh.1	-	7	645	c.442C>T	c.(442-444)CGT>TGT	p.R148C	SAR1A_uc010qji.1_Missense_Mutation_p.R148C|SAR1A_uc010qjj.1_Missense_Mutation_p.R105C	NM_001142648	NP_001136120	Q9NR31	SAR1A_HUMAN	SAR1a gene homolog 1	148					ER to Golgi vesicle-mediated transport|intracellular protein transport	Golgi apparatus	GTP binding|GTPase activity				0						AATATCTCACGGAGTTTTTCT	0.338													31	196					0	0	0	0	A	71913632	A	A	71913632	3	1	84	1	0	0	0	0	1	0	0	0	13904	1116	39	1	162	1	SAR1A	10	71913632	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1666686	71913632	63621115	208	16776											
KCNMA1	3778	broad.mit.edu	37	chr10	78674745	78674745	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agttgtgatggatggttgacGtaacatcccgtgcactgggc	8	11	14	8	2	0	2	0	2	0	0	1	3	1	3	1	3	2	4	1	3	1	3	rs143599540	by1000genomes	TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:78674745G>A	uc001jxn.2	-	24	3142	c.2965C>T	c.(2965-2967)CGT>TGT	p.R989C	KCNMA1_uc001jxj.2_Missense_Mutation_p.R935C|KCNMA1_uc001jxk.1_Missense_Mutation_p.R607C|KCNMA1_uc009xrt.1_Missense_Mutation_p.R780C|KCNMA1_uc001jxl.1_Missense_Mutation_p.R614C|KCNMA1_uc001jxo.2_Missense_Mutation_p.R972C|KCNMA1_uc001jxm.2_Missense_Mutation_p.R931C|KCNMA1_uc001jxq.2_Missense_Mutation_p.R934C	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	989	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	GATGGTTGACGTAACATCCCG	0.483													22	167					0	0	0	0	A	78674745	A	A	78674745	3	1	84	1	0	0	0	0	1	0	0	0	8112	1145	40	1	794	1	KCNMA1	10	78674745	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	6761113	78674745	56860002	209	16777											
RGR	5995	broad.mit.edu	37	chr10	86017674	86017674	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccactctgccagcaaggaCgctgctgctcggctggggcc	6	6	13	16	2	1	0	0	0	1	0	2	1	1	1	3	4	4	5	3	4	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:86017674C>A	uc001kdc.1	+	6	694	c.656C>A	c.(655-657)ACG>AAG	p.T219K	RGR_uc001kdd.1_Missense_Mutation_p.T223K|RGR_uc001kde.1_Intron	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	219	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						CCAGCAAGGACGCTGCTGCTC	0.552													11	35					1.08611e-07	1.59413e-07	1	0	A	86017674	A	A	86017674	3	1	84	1	0	0	0	0	1	0	0	0	13356	536	19	3	690	3	RGR	10	86017674	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	7342929	86017674	49517073	210	16778											
PDLIM1	9124	broad.mit.edu	37	chr10	97050586	97050586	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgctcttacccgggaaatGgcgagaggctgctcgaagtc	8	8	14	11	3	1	1	0	0	1	1	3	4	1	2	1	3	3	4	1	3	3	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:97050586G>A	uc001kkh.2	-	1	196	c.87C>T	c.(85-87)GCC>GCT	p.A29A	PDLIM1_uc001kki.2_Silent_p.A29A|PDLIM1_uc009xuv.2_Silent_p.A29A|PDLIM1_uc001kkj.1_Silent_p.A29A	NM_020992	NP_066272	O00151	PDLI1_HUMAN	PDZ and LIM domain 1	29	PDZ.				response to oxidative stress	cytoplasm|cytoskeleton	zinc ion binding				0		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		CCCGGGAAATGGCGAGAGGCT	0.706													9	21					0	0	0	0	A	97050586	A	A	97050586	2	1	84	1	0	0	0	0	0	0	0	1	11733	1335	47	4		4	PDLIM1	10	97050586	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	11032912	97050586	38484161	211	16779											
TCTN3	26123	broad.mit.edu	37	chr10	97440281	97440281	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgatacatgagcttgcGggttggacaggagacctaca	10	9	12	10	1	0	3	0	2	0	1	1	5	1	4	2	3	4	2	2	3	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:97440281G>A	uc001klb.3	-	13	1782	c.1538C>T	c.(1537-1539)CCG>CTG	p.P513L	TCTN3_uc001kla.3_Missense_Mutation_p.P357L|TCTN3_uc010qoi.1_Missense_Mutation_p.P365L	NM_015631	NP_056446	Q6NUS6	TECT3_HUMAN	tectonic 3 isoform a precursor	513	Extracellular (Potential).				apoptosis	integral to membrane					0		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)		ATGAGCTTGCGGGTTGGACAG	0.458													35	148					0	0	0	0	A	97440281	A	A	97440281	3	1	84	1	0	0	0	0	1	0	0	0	15790	1116	39	1	293	1	TCTN3	10	97440281	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	389695	97440281	38094466	212	16780											
LCOR	84458	broad.mit.edu	37	chr10	98714903	98714903	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtccacagctgccagccttGggccatctggattacagaat	9	10	10	12	0	1	1	0	0	1	1	2	2	2	2	4	2	4	1	4	2	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:98714903G>A	uc001kms.1	+	8	1047	c.526G>A	c.(526-528)GGG>AGG	p.G176R	LCOR_uc001kmr.2_Missense_Mutation_p.G176R|C10orf12_uc009xvg.1_Intron|LCOR_uc001kmt.1_Missense_Mutation_p.G176R|LCOR_uc001kmu.1_Missense_Mutation_p.G176R	NM_032440	NP_115816	Q96JN0	LCOR_HUMAN	ligand dependent nuclear receptor corepressor	176						nucleus	DNA binding			ovary(3)	3		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		TGCCAGCCTTGGGCCATCTGG	0.463													24	33					0	0	0	0	A	98714903	A	A	98714903	3	1	84	1	0	0	0	0	1	0	0	0	8729	1348	47	4	536	4	LCOR	10	98714903	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1274622	98714903	36819844	213	16781											
PDCD11	22984	broad.mit.edu	37	chr10	105162964	105162964	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccccaatggcctccagggCtttgtgcaagtcactgaaat	9	10	9	13	0	1	1	1	1	0	0	3	1	3	1	4	2	1	2	4	2	3	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:105162964C>A	uc001kwy.1	+	4	411	c.324C>A	c.(322-324)GGC>GGA	p.G108G		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	108	S1 motif 1.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GCCTCCAGGGCTTTGTGCAAG	0.473													76	135					3.54697e-40	6.70451e-40	1	0	A	105162964	A	A	105162964	2	1	84	1	0	0	0	0	0	0	0	1	11671	784	28	4		4	PDCD11	10	105162964	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	6448061	105162964	30371783	214	16782											
C10orf81	79949	broad.mit.edu	37	chr10	115526201	115526201	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acattttcttatgaaaatgaAgtctgcaaacaagattactt	16	14	5	6	0	2	3	0	2	2	1	2	3	2	3	0	0	3	1	0	0	7	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:115526201A>C	uc001lat.1	+	2	604	c.42A>C	c.(40-42)GAA>GAC	p.E14D	C10orf81_uc001lar.1_Missense_Mutation_p.E20D|C10orf81_uc009xyc.1_5'UTR|C10orf81_uc001las.1_Intron	NM_024889	NP_079165	Q5SXH7	CJ081_HUMAN	hypothetical protein LOC79949	14	PH.									central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		ATGAAAATGAAGTCTGCAAAC	0.353													8	57					0	0	0	0	C	115526201	C	C	115526201	3	2	84	1	0	0	0	0	1	0	0	0	1625	69	3	5	66	5	C10orf81	10	115526201	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	10363237	115526201	20008546	215	16783											
CPXM2	119587	broad.mit.edu	37	chr10	125530532	125530532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attctggtgatattgggacaCatttcattcacaactttcat	11	16	6	8	0	4	1	3	1	1	0	4	2	4	2	0	2	1	0	0	2	2	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:125530532C>T	uc001lhk.1	-	8	1327	c.1002G>A	c.(1000-1002)ATG>ATA	p.M334I	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	334					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TATTGGGACACATTTCATTCA	0.433													36	257					0	0	0	0	T	125530532	T	T	125530532	3	4	84	1	0	0	0	0	1	0	0	0	3853	478	17	4	1296	4	CPXM2	10	125530532	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	10004331	125530532	10004215	216	16784											
NKX6-2	84504	broad.mit.edu	37	chr10	134598892	134598892	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccagcgcgaagatctgctgGcccgagaaggtcgggcgcga	8	5	16	12	6	1	2	0	0	1	2	3	5	2	2	2	3	2	1	2	3	2	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:134598892G>T	uc001llr.2	-	2	556	c.471C>A	c.(469-471)GGC>GGA	p.G157G		NM_177400	NP_796374	Q9C056	NKX62_HUMAN	NK6 transcription factor related, locus 2	157	Homeobox.					nucleus	sequence-specific DNA binding transcription factor activity				0		all_cancers(35;2.79e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0584)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;4.06e-05)|Epithelial(32;5.53e-05)|all cancers(32;5.99e-05)		AGATCTGCTGGCCCGAGAAGG	0.657													7	8					8.12818e-05	0.000114297	1	0	T	134598892	T	T	134598892	2	4	84	1	0	0	0	0	0	0	0	1	10512	1190	42	4		4	NKX6-2	10	134598892	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	9068360	134598892	935855	217	16785											
KNDC1	85442	broad.mit.edu	37	chr10	135015044	135015044	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccaggaccagcagcagggCcccctgctcacccacctcgg	7	3	12	19	1	1	0	1	0	0	0	2	1	1	1	6	4	3	3	6	4	0	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr10:135015044C>G	uc001llz.1	+	17	3030	c.3029C>G	c.(3028-3030)GCC>GGC	p.A1010G	KNDC1_uc001lma.1_Missense_Mutation_p.A945G|KNDC1_uc001lmb.1_Missense_Mutation_p.A422G	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1010					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		AGCAGCAGGGCCCCCTGCTCA	0.627													12	60					0	0	0	0	G	135015044	G	G	135015044	3	3	84	1	0	0	0	0	1	0	0	0	8465	739	26	4	3095	4	KNDC1	10	135015044	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	416152	135015044	519703	218	16786											
OR51G2	81282	broad.mit.edu	37	chr11	4936073	4936073	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgaccacctggaccaggtggGgtgcctgctttccaaagcga	8	8	13	12	1	0	1	0	1	0	0	1	3	1	2	5	4	3	1	5	4	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:4936073G>T	uc001lzr.1	-	1	821	c.821C>A	c.(820-822)CCC>CAC	p.P274H		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	274	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GACCAGGTGGGGTGCCTGCTT	0.507													28	16					1.16021e-09	1.76807e-09	1	0	T	4936073	T	T	4936073	3	4	84	1	0	0	0	0	1	0	0	0	11153	1232	43	4	127	4	OR51G2	11	4936073	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08		4936073	130070443	219	16787											
MMP26	56547	broad.mit.edu	37	chr11	5013232	5013232	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaactcatgagattgggCattctttgggcctgcagcac	8	12	11	10	0	2	1	1	1	1	1	2	2	2	1	1	2	4	4	1	2	1	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:5013232C>A	uc001lzv.2	+	5	652	c.634C>A	c.(634-636)CAT>AAT	p.H212N		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	212		Zinc; catalytic (By similarity).			collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGAGATTGGGCATTCTTTGGG	0.413													5	33					0.000602214	0.00083941	1	0	A	5013232	A	A	5013232	3	1	84	1	0	0	0	0	1	0	0	0	9716	710	25	4	652	4	MMP26	11	5013232	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	77159	5013232	129993284	220	16788											
OR51B2	79345	broad.mit.edu	37	chr11	5345007	5345007	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggtggaggcagaaagcaCgtgtgataacatgagatttg	12	10	14	5	1	0	3	0	2	0	2	0	5	0	4	0	3	2	2	0	3	2	3	rs140971687		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:5345007C>A	uc001mao.1	-	1	576	c.521G>T	c.(520-522)CGT>CTT	p.R174L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R174R(1)		ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAGAAAGCACGTGTGATAAC	0.388													20	9					4.63292e-17	7.76624e-17	1	0	A	5345007	A	A	5345007	3	1	84	1	0	0	0	0	1	0	0	0	11143	536	19	3	421	3	OR51B2	11	5345007	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	331775	5345007	129661509	221	16789											
OR51B6	390058	broad.mit.edu	37	chr11	5373354	5373354	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttttatttgcaatggtctTgttggactttctcatcatct	7	20	7	7	0	4	0	2	0	3	0	5	1	4	1	0	2	1	3	0	2	2	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:5373354T>C	uc010qzb.1	+	1	617	c.617T>C	c.(616-618)TTG>TCG	p.L206S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAATGGTCTTGTTGGACTTT	0.443													12	20					0	0	0	0	C	5373354	C	C	5373354	3	2	84	1	0	0	0	0	1	0	0	0	11146	1821	63	5	619	5	OR51B6	11	5373354	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	28347	5373354	129633162	222	16790											
DCHS1	8642	broad.mit.edu	37	chr11	6661270	6661270	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagtgataatgcctgaggtGgggtcaatggagaaccagtg	11	9	16	5	0	1	3	1	2	0	1	1	4	1	3	2	4	2	1	2	4	4	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:6661270G>T	uc001mem.1	-	2	1985	c.1575C>A	c.(1573-1575)CCC>CCA	p.P525P		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	525	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCTGAGGTGGGGTCAATGG	0.587													18	14					1.67942e-08	2.49368e-08	1	0	T	6661270	T	T	6661270	2	4	84	1	0	0	0	0	0	0	0	1	4304	1335	47	4		4	DCHS1	11	6661270	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1287916	6661270	128345246	223	16791											
COPB1	1315	broad.mit.edu	37	chr11	14496152	14496152	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatccagaaggaatcctctCaagggaggtctgcaaagcaa	14	6	10	11	0	2	1	1	0	2	1	5	3	4	3	3	3	2	2	3	3	5	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:14496152C>G	uc001mli.2	-	14	1933	c.1626G>C	c.(1624-1626)TTG>TTC	p.L542F	COPB1_uc001mlg.2_Missense_Mutation_p.L542F|COPB1_uc001mlh.2_Missense_Mutation_p.L542F	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	542					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						GGAATCCTCTCAAGGGAGGTC	0.443													28	133					0	0	0	0	G	14496152	G	G	14496152	3	3	84	1	0	0	0	0	1	0	0	0	3743	825	29	2	1271	2	COPB1	11	14496152	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	7834882	14496152	120510364	224	16792											
TPH1	7166	broad.mit.edu	37	chr11	18057644	18057644	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcaaattctgagtttcttcTttttgattttcgggactcga	7	19	7	8	2	4	2	1	2	3	0	6	4	4	3	0	1	0	1	0	1	1	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:18057644T>C	uc001mnp.2	-	2	189	c.163A>G	c.(163-165)AGA>GGA	p.R55G	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	55	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	GAGTTTCTTCTTTTTGATTTT	0.353													28	32					0	0	0	0	C	18057644	C	C	18057644	3	2	84	1	0	0	0	0	1	0	0	0	16468	1617	56	5	1207	5	TPH1	11	18057644	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	3561492	18057644	116948872	225	16793											
MRGPRX3	117195	broad.mit.edu	37	chr11	18158887	18158887	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcgcgctgacaggaaacgcGgttgtgctctggctcctggg	5	9	16	11	4	1	1	0	1	1	0	3	2	2	2	1	4	2	4	1	4	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:18158887G>A	uc001mnu.2	+	3	499	c.138G>A	c.(136-138)GCG>GCA	p.A46A		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	46	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						CAGGAAACGCGGTTGTGCTCT	0.602													6	131					0	0	0	0	A	18158887	A	A	18158887	2	1	84	1	0	0	0	0	0	0	0	1	9821	1103	39	1		1	MRGPRX3	11	18158887	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	101243	18158887	116847629	226	16794											
E2F8	79733	broad.mit.edu	37	chr11	19256552	19256556	+	Frame_Shift_Del	DEL	TATGT	-	-																															tttggcgaggcggctcaccaTatgtaaactctctaggacgt																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:19256552_19256556delTATGT	uc001mpm.2	-	5	1023_1027	c.501_505delACATA	c.(499-507)TTACATATGfs	p.L167fs	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Frame_Shift_Del_p.L167fs	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	167_169	Potential.				cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						CGGCTCACCATATGTAAACTCTCTA	0.444													---	---	---								-	19256556	-	-	19256552	7	5	84	1	0	1	0	1	0	0	0	0	4895	1406	49	0	2134	0	E2F8	11	19256552	Frame_Shift_Del	DEL	TATGT	TCGA-CN-6992-01A-11D-1912-08	1097665	19256552	115749964	227	16795											
ANO5	203859	broad.mit.edu	37	chr11	22301227	22301227	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctcaacaaattaaaagaGaacttgggaattaattctaa	19	10	7	5	0	2	1	1	0	1	1	2	4	2	2	0	1	3	1	0	1	8	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:22301227G>T	uc001mqi.2	+	22	2975	c.2658G>T	c.(2656-2658)GAG>GAT	p.E886D	ANO5_uc001mqj.2_Missense_Mutation_p.E885D	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	886	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						AATTAAAAGAGAACTTGGGAA	0.348													17	38					1.5739e-10	2.45729e-10	1	0	T	22301227	T	T	22301227	3	4	84	1	0	0	0	0	1	0	0	0	700	933	33	2	2744	2	ANO5	11	22301227	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3044675	22301227	112705289	228	16796											
SLC5A12	159963	broad.mit.edu	37	chr11	26734190	26734190	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccatgaccacttaccgTctgtacaatgtagatgaccg	11	9	9	12	2	1	3	0	2	1	1	1	3	1	3	4	0	3	3	4	0	4	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:26734190T>A	uc001mra.2	-	2	716	c.403A>T	c.(403-405)ACG>TCG	p.T135S	SLC5A12_uc001mrb.2_RNA|SLC5A12_uc001mrc.3_Missense_Mutation_p.T135S	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	135	Helical; (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						CCACTTACCGTCTGTACAATG	0.423													136	207					0	0	0	0	A	26734190	A	A	26734190	3	1	84	1	0	0	0	0	1	0	0	0	14728	1667	58	5	1509	5	SLC5A12	11	26734190	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	4432963	26734190	108272326	229	16797											
RAG1	5896	broad.mit.edu	37	chr11	36595801	36595801	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcatgtcttttgccgggtctGcattctcagatgcctcaaag	7	13	10	11	1	4	1	2	0	3	1	5	1	4	1	2	1	3	2	2	1	1	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:36595801G>T	uc001mwu.3	+	2	1071	c.947G>T	c.(946-948)TGC>TTC	p.C316F	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	316	RING-type.	Zinc 2 (By similarity).			histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				TGCCGGGTCTGCATTCTCAGA	0.507									Familial_Hemophagocytic_Lymphohistiocytosis				34	32					1.71269e-34	3.16228e-34	1	0	T	36595801	T	T	36595801	3	4	84	1	0	0	0	0	1	0	0	0	13068	1319	46	4	949	4	RAG1	11	36595801	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	9861611	36595801	98410715	230	16798											
TTC17	55761	broad.mit.edu	37	chr11	43428727	43428727	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataactatactatcccagaaGaagaaattgggtctttctta	15	13	6	7	0	2	3	0	0	2	3	3	3	3	3	1	1	2	0	1	1	8	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:43428727G>T	uc001mxi.2	+	14	1815	c.1801G>T	c.(1801-1803)GAA>TAA	p.E601*	TTC17_uc001mxh.2_Nonsense_Mutation_p.E601*|TTC17_uc010rfj.1_Nonsense_Mutation_p.E544*|TTC17_uc001mxj.2_Nonsense_Mutation_p.E371*	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	601							binding			ovary(5)	5						TATCCCAGAAGAAGAAATTGG	0.284													31	37					1.36615e-20	2.41732e-20	1	0	T	43428727	T	T	43428727	4	4	84	1	0	0	0	0	0	1	0	0	16752	943	33	2	1855	2	TTC17	11	43428727	Nonsense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	6832926	43428727	91577789	231	16799											
OR4C16	219428	broad.mit.edu	37	chr11	55340173	55340173	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacaagcctgttcagaaacCtatgtggttaacctactcct	13	11	6	11	0	1	1	1	0	0	1	2	1	2	1	4	1	5	2	4	1	6	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:55340173C>A	uc010rih.1	+	1	570	c.570C>A	c.(568-570)ACC>ACA	p.T190T		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GTTCAGAAACCTATGTGGTTA	0.433													33	43					6.00712e-18	1.02314e-17	1	0	A	55340173	A	A	55340173	2	1	84	1	0	0	0	0	0	0	0	1	11103	668	24	4		4	OR4C16	11	55340173	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	11911446	55340173	79666343	232	16800											
CLP1	10978	broad.mit.edu	37	chr11	57428441	57428441	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atgaactgaaacgggacctcCcccactttgtacgcactgtg	10	9	9	13	2	0	2	0	2	0	0	1	3	1	3	3	1	3	2	3	1	3	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:57428441C>T	uc001nkw.2	+	3	950	c.811C>T	c.(811-813)CCC>TCC	p.P271S	CLP1_uc010rjw.1_Missense_Mutation_p.P207S|CLP1_uc009yml.2_Missense_Mutation_p.P271S	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	271					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1						ACGGGACCTCCCCCACTTTGT	0.542													51	92					0	0	0	0	T	57428441	T	T	57428441	3	4	84	1	0	0	0	0	1	0	0	0	3565	623	22	4	817	4	CLP1	11	57428441	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2088268	57428441	77578075	233	16801											
OR5A2	219981	broad.mit.edu	37	chr11	59189605	59189605	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcatagaatatggacacCaccttgtccctgtttaggga	12	10	10	9	0	0	1	0	0	0	1	1	3	1	3	3	3	0	2	3	3	5	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:59189605C>A	uc010rkt.1	-	1	822	c.822G>T	c.(820-822)GTG>GTT	p.V274V		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATATGGACACCACCTTGTCCC	0.468													27	14					5.61819e-17	9.39314e-17	1	0	A	59189605	A	A	59189605	2	1	84	1	0	0	0	0	0	0	0	1	11194	581	21	4		4	OR5A2	11	59189605	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1761164	59189605	75816911	234	16802											
MS4A6A	64231	broad.mit.edu	37	chr11	59949134	59949134	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggttcgggtttctctgcttGggagaagttgatgacatttg	6	15	15	5	1	1	3	0	2	1	1	3	4	1	3	0	3	1	4	0	3	1	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:59949134G>T	uc001nor.2	-	2	305	c.67C>A	c.(67-69)CAA>AAA	p.Q23K	MS4A6A_uc001noq.2_Missense_Mutation_p.Q23K|MS4A6A_uc001nos.3_Missense_Mutation_p.Q51K|MS4A6A_uc009ymv.2_Missense_Mutation_p.Q23K|MS4A6A_uc001not.2_Missense_Mutation_p.Q23K|MS4A6A_uc010rla.1_Missense_Mutation_p.Q51K|MS4A6A_uc010rlb.1_Missense_Mutation_p.Q23K	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	23	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						TTCTCTGCTTGGGAGAAGTTG	0.428													47	43					4.01344e-20	7.06232e-20	1	0	T	59949134	T	T	59949134	3	4	84	1	0	0	0	0	1	0	0	0	9917	1357	47	4	730	4	MS4A6A	11	59949134	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	759529	59949134	75057382	235	16803											
AHNAK	79026	broad.mit.edu	37	chr11	62298255	62298255	+	Frame_Shift_Del	DEL	C	-	-																															gggcacagacacatccacatCccctttgactttggggcctt																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:62298255delC	uc001ntl.2	-	5	3934	c.3634delG	c.(3634-3636)GATfs	p.D1212fs	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1212					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACATCCACATCCCCTTTGACT	0.478													---	---	---								-	62298255	-	-	62298255	7	5	84	1	0	1	0	1	0	0	0	0	414	855	30	0	14158	0	AHNAK	11	62298255	Frame_Shift_Del	DEL	C	TCGA-CN-6992-01A-11D-1912-08	2349121	62298255	72708261	236	16804											
SLC22A25	387601	broad.mit.edu	37	chr11	62948160	62948160	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggacaggaaacagattctttTacatatgttgggtatgcgga	12	12	12	5	1	1	1	0	0	1	1	1	4	1	4	0	4	3	2	0	4	4	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:62948160T>C	uc001nwr.1	-	6	1042	c.1042A>G	c.(1042-1044)AAA>GAA	p.K348E	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA|SLC22A25_uc001nwt.1_Missense_Mutation_p.K348E	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	348	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						CAGATTCTTTTACATATGTTG	0.373													29	16					0	0	0	0	C	62948160	C	C	62948160	3	2	84	1	0	0	0	0	1	0	0	0	14518	1763	61	5	617	5	SLC22A25	11	62948160	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	649905	62948160	72058356	237	16805											
PC	5091	broad.mit.edu	37	chr11	66619265	66619265	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccaccccaggctcacttgaAgaccacgttgtctgggtagt	8	9	10	14	1	2	2	1	1	1	1	2	2	2	2	4	2	0	3	4	2	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:66619265A>T	uc001ojn.1	-	14	2027	c.1978T>A	c.(1978-1980)TTC>ATC	p.F660I	PC_uc001ojo.1_Missense_Mutation_p.F660I|PC_uc001ojp.1_Missense_Mutation_p.F660I|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	660	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GCTCACTTGAAGACCACGTTG	0.627													17	25					0	0	0	0	T	66619265	T	T	66619265	3	4	84	1	0	0	0	0	1	0	0	0	11551	72	3	5	1590	5	PC	11	66619265	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	3671105	66619265	68387251	238	16806											
RSF1	51773	broad.mit.edu	37	chr11	77413134	77413134	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtttttttagtggtatcttGgcctgctggtcatttttaag	5	20	10	6	1	2	0	1	0	1	0	2	0	2	0	1	3	1	3	1	3	3	9			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:77413134G>A	uc001oyn.2	-	6	1260	c.1140C>T	c.(1138-1140)GCC>GCT	p.A380A	RSF1_uc001oym.2_Silent_p.A128A	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	380					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			GTGGTATCTTGGCCTGCTGGT	0.358													55	72					0	0	0	0	A	77413134	A	A	77413134	2	1	84	1	0	0	0	0	0	0	0	1	13764	1335	47	4		4	RSF1	11	77413134	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	10793869	77413134	57593382	239	16807											
C11orf52	91894	broad.mit.edu	37	chr11	111796859	111796859	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttagaaaacgctacagagtAtgcgacccttcgcttccccc	10	10	7	14	3	0	2	0	0	0	2	2	3	1	2	3	0	3	3	3	0	5	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:111796859A>G	uc001pmh.2	+	5	791	c.308A>G	c.(307-309)TAT>TGT	p.Y103C	C11orf52_uc001pmi.2_Missense_Mutation_p.Y103C	NM_080659	NP_542390	Q96A22	CK052_HUMAN	hypothetical protein LOC91894	103										ovary(1)	1		all_cancers(61;8.8e-15)|all_epithelial(67;6.27e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.63e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.7e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0512)		GCTACAGAGTATGCGACCCTT	0.547													26	14					0	0	0	0	G	111796859	G	G	111796859	3	3	84	1	0	0	0	0	1	0	0	0	1653	449	16	5	322	5	C11orf52	11	111796859	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	34383725	111796859	23209657	240	16808											
CADM1	23705	broad.mit.edu	37	chr11	115049407	115049407	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagaatgatgagcaagcaCagcatggcgaacaccaccac	15	3	9	14	1	0	3	0	2	0	1	0	4	0	3	3	1	4	3	3	1	3	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:115049407C>G	uc001ppi.3	-	9	1296	c.1167G>C	c.(1165-1167)CTG>CTC	p.L389L	CADM1_uc001ppf.3_Silent_p.L361L|CADM1_uc001ppk.3_Silent_p.L361L|CADM1_uc001ppj.3_Silent_p.L390L|CADM1_uc001pph.3_Silent_p.L152L	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	389	Helical; (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		TGAGCAAGCACAGCATGGCGA	0.542													52	45					0	0	0	0	G	115049407	G	G	115049407	2	3	84	1	0	0	0	0	0	0	0	1	2578	465	17	4		4	CADM1	11	115049407	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3252548	115049407	19957109	241	16809											
HINFP	25988	broad.mit.edu	37	chr11	119003446	119003446	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcaaccacatgcgctttcGtcacagtgaggaccggccct	8	7	10	16	4	1	1	1	1	0	0	2	2	1	2	4	2	2	2	4	2	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:119003446G>T	uc001pvp.2	+	8	1019	c.830G>T	c.(829-831)CGT>CTT	p.R277L	HINFP_uc001pvq.2_Missense_Mutation_p.R277L|HINFP_uc001pvr.2_Missense_Mutation_p.R30L	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	277	C2H2-type 6.				DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						ATGCGCTTTCGTCACAGTGAG	0.542													40	29					1.30091e-30	2.37444e-30	1	0	T	119003446	T	T	119003446	3	4	84	1	0	0	0	0	1	0	0	0	7149	1145	40	3	852	3	HINFP	11	119003446	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3954039	119003446	16003070	242	16810											
TECTA	7007	broad.mit.edu	37	chr11	120989055	120989055	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggtgttttgggatgacttGaactgcaccgtcaagtgccg	8	11	14	8	2	1	2	1	2	0	0	1	4	1	3	2	2	3	2	2	2	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:120989055G>A	uc010rzo.1	+	6	831	c.831G>A	c.(829-831)TTG>TTA	p.L277L		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	277	VWFC.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGGATGACTTGAACTGCACCG	0.408													18	16					0	0	0	0	A	120989055	A	A	120989055	2	1	84	1	0	0	0	0	0	0	0	1	15813	1281	45	2		2	TECTA	11	120989055	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1985609	120989055	14017461	243	16811											
KIRREL3	84623	broad.mit.edu	37	chr11	126301325	126301325	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcccgtacttctctgggaaCgggcacagcagaacgccacg	9	6	11	15	4	1	1	0	0	1	1	3	2	2	2	2	2	4	3	2	2	3	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr11:126301325C>A	uc001qea.2	-	14	2046	c.1685G>T	c.(1684-1686)CGT>CTT	p.R562L	KIRREL3_uc001qeb.2_Missense_Mutation_p.R550L|KIRREL3_uc001qec.1_Missense_Mutation_p.R562L|ST3GAL4_uc001qdx.1_Intron	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	562	Cytoplasmic (Potential).				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		TCTCTGGGAACGGGCACAGCA	0.607													16	12					5.01169e-05	7.126e-05	1	0	A	126301325	A	A	126301325	3	1	84	1	0	0	0	0	1	0	0	0	8365	536	19	3	774	3	KIRREL3	11	126301325	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	5312270	126301325	8705191	244	16812											
WNK1	65125	broad.mit.edu	37	chr12	990928	990928	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagacccaagctacccagcCgaccactttggcttcctctg	9	8	7	17	1	1	1	0	0	1	1	2	2	2	1	5	1	3	2	5	1	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:990928C>T	uc001qio.3	+	13	3689	c.3182C>T	c.(3181-3183)CCG>CTG	p.P1061L	WNK1_uc001qip.3_Missense_Mutation_p.P814L|WNK1_uc001qir.3_Missense_Mutation_p.P234L	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1061					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GCTACCCAGCCGACCACTTTG	0.473													21	100					0	0	0	0	T	990928	T	T	990928	3	4	84	1	0	0	0	0	1	0	0	0	17445	652	23	1	4734	1	WNK1	12	990928	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08		990928	132860967	245	16813											
KCNA6	3742	broad.mit.edu	37	chr12	4919476	4919476	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtacttcttcgaccgcaaccGgcccagcttcgacgccatcc	7	8	8	18	5	1	0	0	0	1	0	4	2	2	0	5	1	3	3	5	1	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:4919476G>A	uc001qng.2	+	1	1135	c.269G>A	c.(268-270)CGG>CAG	p.R90Q		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	90						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						GACCGCAACCGGCCCAGCTTC	0.647										HNSCC(72;0.22)			40	50					0	0	0	0	A	4919476	A	A	4919476	3	1	84	1	0	0	0	0	1	0	0	0	8046	1116	39	1	271	1	KCNA6	12	4919476	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3928548	4919476	128932419	246	16814											
TNFRSF1A	7132	broad.mit.edu	37	chr12	6438763	6438763	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggggcacgttctccaccacGgcgtacagcgtcgcggggtc	5	6	16	14	6	1	0	0	0	1	0	4	0	1	0	2	5	2	3	2	5	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:6438763G>A	uc001qnu.2	-	10	1364	c.1083C>T	c.(1081-1083)GCC>GCT	p.A361A	TNFRSF1A_uc001qnt.2_Silent_p.A253A|TNFRSF1A_uc010sey.1_Silent_p.A129A|TNFRSF1A_uc010sez.1_Silent_p.A253A|TNFRSF1A_uc009zek.2_Silent_p.A318A	NM_001065	NP_001056	P19438	TNR1A_HUMAN	tumor necrosis factor receptor 1 precursor	361	Death.|Cytoplasmic (Potential).				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			lung(2)|skin(1)	3						TCTCCACCACGGCGTACAGCG	0.726													3	14					0	0	0	0	A	6438763	A	A	6438763	2	1	84	1	0	0	0	0	0	0	0	1	16359	1103	39	1		1	TNFRSF1A	12	6438763	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1519287	6438763	127413132	247	16815											
PRB2	653247	broad.mit.edu	37	chr12	11546608	11546608	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccttgtggctttcctggaGgaggtggaggaccttgaggc	5	11	17	8	0	0	1	0	1	0	0	2	5	2	5	3	7	0	1	3	7	0	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:11546608G>T	uc010shk.1	-	3	439	c.404C>A	c.(403-405)CCT>CAT	p.P135H		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTTTCCTGGAGGAGGTGGAGG	0.607													149	351					4.76656e-67	9.14548e-67	1	0	T	11546608	T	T	11546608	3	4	84	1	0	0	0	0	1	0	0	0	12505	1000	35	4	850	4	PRB2	12	11546608	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	5107845	11546608	122305287	248	16816											
ATF7IP	55729	broad.mit.edu	37	chr12	14578009	14578009	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttggagaagatgctatatCtagcagtatggaaattgacc	13	12	10	6	0	2	3	0	1	2	2	2	5	2	4	1	2	2	3	1	2	6	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:14578009C>G	uc001rbw.2	+	2	1318	c.1160C>G	c.(1159-1161)TCT>TGT	p.S387C	ATF7IP_uc010shs.1_Missense_Mutation_p.S387C|ATF7IP_uc001rbu.2_Missense_Mutation_p.S387C|ATF7IP_uc001rbv.1_Missense_Mutation_p.S387C|ATF7IP_uc001rbx.2_Missense_Mutation_p.S387C|ATF7IP_uc010sht.1_Missense_Mutation_p.S387C|ATF7IP_uc001rby.3_Missense_Mutation_p.S387C|ATF7IP_uc001rbz.1_Missense_Mutation_p.S387C|ATF7IP_uc001rca.2_Missense_Mutation_p.S387C|ATF7IP_uc001rcb.2_Translation_Start_Site	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	387	Glu-rich.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						GATGCTATATCTAGCAGTATG	0.343													15	91					0	0	0	0	G	14578009	G	G	14578009	3	3	84	1	0	0	0	0	1	0	0	0	1089	913	32	2	1162	2	ATF7IP	12	14578009	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3031401	14578009	119273886	249	16817											
ABCC9	10060	broad.mit.edu	37	chr12	22063217	22063217	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggataagttagacgtagaGagcctaaggattttattata	15	13	10	3	1	0	2	0	0	0	2	0	5	0	4	1	2	1	2	1	2	7	8			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:22063217G>T	uc001rfi.1	-	8	1214	c.1194C>A	c.(1192-1194)CTC>CTA	p.L398L	ABCC9_uc001rfh.2_Silent_p.L398L|ABCC9_uc001rfj.1_Silent_p.L398L	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	398	Cytoplasmic (Potential).|ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TAGACGTAGAGAGCCTAAGGA	0.353													8	58					2.17888e-05	3.11198e-05	1	0	T	22063217	T	T	22063217	2	4	84	1	0	0	0	0	0	0	0	1	59	929	33	2		2	ABCC9	12	22063217	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	7485208	22063217	111788678	250	16818											
DENND5B	160518	broad.mit.edu	37	chr12	31542309	31542309	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccatccttcccaatgttcCtgggtgcagtattaatagca	9	13	8	11	0	0	0	0	0	0	0	3	0	3	0	4	1	3	4	4	1	4	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:31542309C>T	uc001rki.1	-	20	3776	c.3590G>A	c.(3589-3591)AGG>AAG	p.R1197K	DENND5B_uc001rkh.1_Missense_Mutation_p.R1232K|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1197	RUN 2.					integral to membrane				ovary(1)|central_nervous_system(1)	2						CCCAATGTTCCTGGGTGCAGT	0.373													13	24					0	0	0	0	T	31542309	T	T	31542309	3	4	84	1	0	0	0	0	1	0	0	0	4459	681	24	4	242	4	DENND5B	12	31542309	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	9479092	31542309	102309586	251	16819											
PRPF40B	25766	broad.mit.edu	37	chr12	50035774	50035774	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacaagagggctgccgcactGgacgcaggcaacatcaagct	12	4	13	12	2	1	1	1	0	0	1	1	3	1	2	1	3	3	5	1	3	3	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:50035774G>A	uc001rur.1	+	18	1849	c.1785G>A	c.(1783-1785)CTG>CTA	p.L595L	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001rup.1_Silent_p.L617L|PRPF40B_uc001ruq.1_Silent_p.L582L|PRPF40B_uc001rus.1_Silent_p.L538L|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	595					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CTGCCGCACTGGACGCAGGCA	0.567													22	90					0	0	0	0	A	50035774	A	A	50035774	2	1	84	1	0	0	0	0	0	0	0	1	12634	1335	47	4		4	PRPF40B	12	50035774	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	18493465	50035774	83816121	252	16820											
PRPF40B	25766	broad.mit.edu	37	chr12	50036073	50036073	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagaaggaggaggcacgcaGgatgcggcgcagggaagctg	11	2	21	7	3	0	1	0	0	0	1	0	6	0	5	0	7	2	4	0	7	2	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:50036073G>A	uc001rur.1	+	19	1938	c.1874G>A	c.(1873-1875)AGG>AAG	p.R625K	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001rup.1_Missense_Mutation_p.R647K|PRPF40B_uc001ruq.1_Missense_Mutation_p.R612K|PRPF40B_uc001rus.1_Missense_Mutation_p.R568K|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	625					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GAGGCACGCAGGATGCGGCGC	0.637													16	64					0	0	0	0	A	50036073	A	A	50036073	3	1	84	1	0	0	0	0	1	0	0	0	12634	1000	35	4	1948	4	PRPF40B	12	50036073	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	299	50036073	83815822	253	16821											
SCN8A	6334	broad.mit.edu	37	chr12	52078000	52078000	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaaaactctcttcagatttAgtgccacgcctgccttgtac	9	12	8	12	1	2	1	1	0	1	1	3	2	2	2	3	1	4	1	3	1	4	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:52078000A>G	uc001ryw.2	+	3	497	c.319A>G	c.(319-321)AGT>GGT	p.S107G	SCN8A_uc010snl.1_5'Flank|SCN8A_uc001ryx.1_5'Flank|SCN8A_uc001ryz.1_5'Flank|SCN8A_uc001ryy.2_5'Flank	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	107					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CTTCAGATTTAGTGCCACGCC	0.358													25	44					0	0	0	0	G	52078000	G	G	52078000	3	3	84	1	0	0	0	0	1	0	0	0	13989	420	15	5	325	5	SCN8A	12	52078000	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	2041927	52078000	81773895	254	16822											
ATF7	11016	broad.mit.edu	37	chr12	53925601	53925601	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctgggcgggctgtcaccAtggtgctggcagtacccacc	5	8	14	14	1	2	0	1	0	1	0	2	0	2	0	3	4	2	5	3	4	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:53925601A>G	uc001sdy.2	-	8	908	c.887T>C	c.(886-888)ATG>ACG	p.M296T	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Missense_Mutation_p.M285T|ATF7_uc010sol.1_Missense_Mutation_p.M264T	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	296	Transactivation domain.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						GGCTGTCACCATGGTGCTGGC	0.537													12	22					0	0	0	0	G	53925601	G	G	53925601	3	3	84	1	0	0	0	0	1	0	0	0	1088	217	8	5	613	5	ATF7	12	53925601	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	1847601	53925601	79926294	255	16823											
GRIP1	23426	broad.mit.edu	37	chr12	66814550	66814550	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatgacgagggggtctccTggttttctactggatggtgc	7	12	15	7	1	2	1	0	1	2	0	3	4	2	2	1	5	2	1	1	5	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:66814550T>A	uc001stk.2	-	14	1873	c.1632A>T	c.(1630-1632)CCA>CCT	p.P544P	GRIP1_uc010sta.1_Silent_p.P488P|GRIP1_uc001stj.2_Silent_p.P326P|GRIP1_uc001stl.1_Silent_p.P436P|GRIP1_uc001stm.2_Silent_p.P544P	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	596	PDZ 5.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		GGGGGTCTCCTGGTTTTCTAC	0.368													45	82					0	0	0	0	A	66814550	A	A	66814550	2	1	84	1	0	0	0	0	0	0	0	1	6826	1567	55	5		5	GRIP1	12	66814550	Silent	SNP	T	TCGA-CN-6992-01A-11D-1912-08	12888949	66814550	67037345	256	16824											
PTPRR	5801	broad.mit.edu	37	chr12	71286643	71286643	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgtctgtagattttttgtGgggctatatccaggctcttc	6	18	10	7	0	2	1	0	0	2	1	4	1	3	1	1	3	0	3	1	3	4	8			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:71286643G>T	uc001swi.1	-	2	589	c.173C>A	c.(172-174)CCA>CAA	p.P58Q		NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	58	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GATTTTTTGTGGGGCTATATC	0.408													60	126					7.47603e-22	1.32653e-21	1	0	T	71286643	T	T	71286643	3	4	84	1	0	0	0	0	1	0	0	0	12875	1348	47	4	1852	4	PTPRR	12	71286643	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	4472093	71286643	62565252	257	16825											
DUSP6	1848	broad.mit.edu	37	chr12	89745563	89745563	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccacagcgccgggtgaagCggtcccggtcctcgccgcgc	4	5	15	17	7	0	1	0	1	0	0	3	1	2	1	5	3	3	0	5	3	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:89745563C>A	uc001tay.2	-	1	734	c.254G>T	c.(253-255)CGC>CTC	p.R85L	DUSP6_uc001taz.2_Missense_Mutation_p.R85L	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	85	Rhodanese.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						CCGGGTGAAGCGGTCCCGGTC	0.687													3	8					0.004672	0.00640014	1	0	A	89745563	A	A	89745563	3	1	84	1	0	0	0	0	1	0	0	0	4851	768	27	3	903	3	DUSP6	12	89745563	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	18458920	89745563	44106332	258	16826											
ANKS1B	56899	broad.mit.edu	37	chr12	99223121	99223122	+	Missense_Mutation	DNP	CC	AA	AA																															actgaggaggagtgtgattaCcactgggttcctgaatggaa																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:99223121_99223122CC>AA	uc001tge.1	-	19	3313_3314	c.2896_2897GG>TT	c.(2896-2898)GGT>TTT	p.G966F	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc001tgk.2_Missense_Mutation_p.G263F|ANKS1B_uc010svd.1_5'UTR|ANKS1B_uc001tgd.1_Intron|ANKS1B_uc009ztq.2_5'UTR|ANKS1B_uc010sve.1_5'UTR|ANKS1B_uc001tgh.3_5'UTR|ANKS1B_uc001tgi.2_Missense_Mutation_p.G192F|ANKS1B_uc009ztr.2_Intron|ANKS1B_uc001tgj.2_Intron|ANKS1B_uc009ztp.2_5'UTR|ANKS1B_uc010svf.1_5'UTR|ANKS1B_uc001tgg.3_Intron|ANKS1B_uc010svg.1_Intron|ANKS1B_uc009zts.1_Missense_Mutation_p.G192F	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	966						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		AGTGTGATTACCACTGGGTTCC	0.441													22	39					0	0	0	0	AA	99223122	AA	AA	99223121	3	1	84	1	0	0	0	0	1	0	0	0	689	507	18	4	1072	4	ANKS1B	12	99223121	Missense_Mutation	DNP	CC	TCGA-CN-6992-01A-11D-1912-08	9477558	99223121	34628774	259	16827											
NR1H4	9971	broad.mit.edu	37	chr12	100904813	100904813	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctgtaacaaagaagcccCgcatgggcgcgtcagcaggg	10	5	14	12	3	1	1	1	0	0	1	1	1	1	1	3	2	4	3	3	2	3	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:100904813C>A	uc001tht.1	+	2	395	c.367C>A	c.(367-369)CGC>AGC	p.R123S	NR1H4_uc001thp.1_Missense_Mutation_p.R113S|NR1H4_uc001thq.1_Missense_Mutation_p.R113S|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Missense_Mutation_p.R113S|NR1H4_uc010svk.1_Missense_Mutation_p.R113S|NR1H4_uc001ths.1_Missense_Mutation_p.R123S	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	123					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						AAAGAAGCCCCGCATGGGCGC	0.527													22	51					3.62473e-10	5.61789e-10	1	0	A	100904813	A	A	100904813	3	1	84	1	0	0	0	0	1	0	0	0	10673	652	23	3	343	3	NR1H4	12	100904813	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1681692	100904813	32947082	260	16828											
TRPV4	59341	broad.mit.edu	37	chr12	110236583	110236583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acgggtgttgtcagcaatggCcaccagcgcatgcagcactg	9	7	13	12	2	1	0	1	0	0	0	1	0	1	0	2	2	4	5	2	2	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:110236583C>T	uc001tpj.1	-	5	1083	c.988G>A	c.(988-990)GCC>ACC	p.A330T	TRPV4_uc001tpg.1_Missense_Mutation_p.A296T|TRPV4_uc001tph.1_Missense_Mutation_p.A283T|TRPV4_uc001tpi.1_Missense_Mutation_p.A283T|TRPV4_uc001tpk.1_Missense_Mutation_p.A330T|TRPV4_uc001tpl.1_Missense_Mutation_p.A330T	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	330	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TCAGCAATGGCCACCAGCGCA	0.592													13	29					0	0	0	0	T	110236583	T	T	110236583	3	4	84	1	0	0	0	0	1	0	0	0	16665	739	26	4	1671	4	TRPV4	12	110236583	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	9331770	110236583	23615312	261	16829											
NAA25	80018	broad.mit.edu	37	chr12	112512522	112512522	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaggcctcttcaatcagtcGaaagacagaatcgaaataag	16	7	8	10	2	3	2	2	0	1	2	5	4	3	2	2	1	0	0	2	1	5	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:112512522G>A	uc001ttm.2	-	9	843	c.823C>T	c.(823-825)CGA>TGA	p.R275*	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Nonsense_Mutation_p.R247*|NAA25_uc009zwa.1_Nonsense_Mutation_p.R275*	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	275						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						TCAATCAGTCGAAAGACAGAA	0.393													25	145					0	0	0	0	A	112512522	A	A	112512522	4	1	84	1	0	0	0	0	0	1	0	0	10174	1066	37	1	2159	1	NAA25	12	112512522	Nonsense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2275939	112512522	21339373	262	16830											
TAOK3	51347	broad.mit.edu	37	chr12	118590137	118590137	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgattttgctctggtaggcGttgagcagctccatttcctg	5	16	11	9	1	1	2	0	2	1	0	3	2	3	2	2	2	3	5	2	2	1	6	rs143511282	byFrequency	TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:118590137G>A	uc001twx.2	-	20	2725	c.2430C>T	c.(2428-2430)AAC>AAT	p.N810N	TAOK3_uc001twv.2_Silent_p.N350N|TAOK3_uc001tww.2_Silent_p.N640N|TAOK3_uc001twy.3_Silent_p.N810N	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	810	Potential.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCTGGTAGGCGTTGAGCAGCT	0.532													43	58					0	0	0	0	A	118590137	A	A	118590137	2	1	84	1	0	0	0	0	0	0	0	1	15615	1136	40	1		1	TAOK3	12	118590137	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	6077615	118590137	15261758	263	16831											
CCDC60	160777	broad.mit.edu	37	chr12	119978426	119978426	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctgcctcacagtttgtgcGagaacacatcatccatatgc	10	11	8	12	1	3	1	2	0	1	1	4	2	4	1	2	0	4	1	2	0	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:119978426G>A	uc001txe.2	+	14	2024	c.1559G>A	c.(1558-1560)CGA>CAA	p.R520Q	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	520										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CAGTTTGTGCGAGAACACATC	0.512													12	92					0	0	0	0	A	119978426	A	A	119978426	3	1	84	1	0	0	0	0	1	0	0	0	2844	1058	37	1	1613	1	CCDC60	12	119978426	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1388289	119978426	13873469	264	16832											
PXN	5829	broad.mit.edu	37	chr12	120650198	120650198	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcccttgttgagctgcttGaggcagaaggcacagacgaa	10	8	14	9	1	0	4	0	2	0	2	0	5	0	4	1	2	3	5	1	2	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr12:120650198G>C	uc001txt.2	-	12	1826	c.1695C>G	c.(1693-1695)CTC>CTG	p.L565L	uc001txs.1_RNA|PXN_uc001txu.2_Silent_p.L377L|PXN_uc001txv.2_Silent_p.L446L|PXN_uc001txx.2_Silent_p.L398L|PXN_uc001txy.2_Silent_p.L531L|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	565	LIM zinc-binding 4.				cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGAGCTGCTTGAGGCAGAAGG	0.587													4	37					0	0	0	0	C	120650198	C	C	120650198	2	2	84	1	0	0	0	0	0	0	0	1	12917	1277	45	2		2	PXN	12	120650198	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	671772	120650198	13201697	265	16833											
SACS	26278	broad.mit.edu	37	chr13	23909308	23909308	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagtcacttcgaacaccaaCtccattatcatcacgccaca	13	8	3	17	2	3	0	3	0	0	0	5	1	4	0	4	0	2	0	4	0	3	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr13:23909308C>A	uc001uon.2	-	10	9296	c.8707G>T	c.(8707-8709)GTT>TTT	p.V2903F	SACS_uc001uoo.2_Missense_Mutation_p.V2756F|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2903					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CGAACACCAACTCCATTATCA	0.418													22	41					0.000295444	0.000413621	1	0	A	23909308	A	A	23909308	3	1	84	1	0	0	0	0	1	0	0	0	13869	565	20	4	5036	4	SACS	13	23909308	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08		23909308	91260570	266	16834											
NBEA	26960	broad.mit.edu	37	chr13	35735894	35735894	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccttctttaggctgtgcAgggtcggtctatcacccaac	6	14	9	12	1	3	0	1	0	2	0	5	0	4	0	2	3	2	2	2	3	3	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr13:35735894A>T	uc001uvb.2	+	24	4075	c.3869A>T	c.(3868-3870)CAG>CTG	p.Q1290L	NBEA_uc010abi.2_5'UTR	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1290						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TAGGCTGTGCAGGGTCGGTCT	0.403													6	19					0	0	0	0	T	35735894	T	T	35735894	3	4	84	1	0	0	0	0	1	0	0	0	10240	188	7	5	3959	5	NBEA	13	35735894	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	11826586	35735894	79433984	267	16835											
OLFM4	10562	broad.mit.edu	37	chr13	53624258	53624258	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtggcgccattgaatacAgatgggagactgttggagta	10	10	16	5	1	0	3	0	1	0	2	0	5	0	4	1	4	1	2	1	4	3	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr13:53624258A>T	uc001vhl.2	+	5	885	c.885A>T	c.(883-885)ACA>ACT	p.T295T	OLFM4_uc001vhk.1_Intron	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	295	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		CATTGAATACAGATGGGAGAC	0.443													40	65					0	0	0	0	T	53624258	T	T	53624258	2	4	84	1	0	0	0	0	0	0	0	1	10909	175	7	5		5	OLFM4	13	53624258	Silent	SNP	A	TCGA-CN-6992-01A-11D-1912-08	17888364	53624258	61545620	268	16836											
C13orf34	79866	broad.mit.edu	37	chr13	73320896	73320896	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacagatgtctcatcacccGccatggatgctgctggaata	10	9	9	13	1	2	1	2	0	1	1	3	3	2	3	3	2	2	2	3	2	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr13:73320896G>A	uc001viv.1	+	10	1248	c.1129G>A	c.(1129-1131)GCC>ACC	p.A377T	C13orf34_uc010thq.1_Missense_Mutation_p.A152T|C13orf34_uc010aen.1_Missense_Mutation_p.A452T|C13orf34_uc010thr.1_Missense_Mutation_p.A307T|C13orf34_uc001viw.1_Missense_Mutation_p.A326T	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	377					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		CTCATCACCCGCCATGGATGC	0.438													33	68					0	0	0	0	A	73320896	A	A	73320896	3	1	84	1	0	0	0	0	1	0	0	0	1734	1087	38	1	1163	1	C13orf34	13	73320896	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	19696638	73320896	41848982	269	16837											
TBC1D4	9882	broad.mit.edu	37	chr13	75936702	75936702	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggcatcctctttcatggcCgctttagataattgccttat	7	17	7	10	1	2	1	1	0	1	1	3	1	3	1	3	2	1	2	3	2	3	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr13:75936702C>T	uc001vjl.1	-	2	887	c.540G>A	c.(538-540)GCG>GCA	p.A180A	TBC1D4_uc010aer.2_Silent_p.A180A|TBC1D4_uc010aes.2_Silent_p.A180A	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	180	PID 1.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		CTTTCATGGCCGCTTTAGATA	0.413													69	151					0	0	0	0	T	75936702	T	T	75936702	2	4	84	1	0	0	0	0	0	0	0	1	15688	639	23	1		1	TBC1D4	13	75936702	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2615806	75936702	39233176	270	16838											
IPO5	3843	broad.mit.edu	37	chr13	98642692	98642692	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcctcttgattttagatcagGacgttatctgctagagctac	9	15	8	9	1	3	3	1	1	2	2	4	4	4	4	1	1	3	3	1	1	4	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr13:98642692G>A	uc001vnf.1	+	6	635	c.570G>A	c.(568-570)AGG>AGA	p.R190R	IPO5_uc001vne.2_Silent_p.R208R|IPO5_uc010tik.1_Intron|IPO5_uc010til.1_Silent_p.R130R	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	190					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						TTTAGATCAGGACGTTATCTG	0.343													21	49					0	0	0	0	A	98642692	A	A	98642692	2	1	84	1	0	0	0	0	0	0	0	1	7835	1165	41	2		2	IPO5	13	98642692	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	22705990	98642692	16527186	271	16839											
RNF113B	140432	broad.mit.edu	37	chr13	98828638	98828638	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagcagcgcggggtggcccGgaagtgctccagcgcgcagc	6	4	18	13	5	0	0	0	0	0	0	1	1	1	1	2	4	5	4	2	4	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr13:98828638G>A	uc001vnk.2	-	1	884	c.853C>T	c.(853-855)CGG>TGG	p.R285W	FARP1_uc001vnh.2_Intron|FARP1_uc001vni.2_Intron|FARP1_uc001vnj.2_Intron	NM_178861	NP_849192	Q8IZP6	R113B_HUMAN	ring finger protein 113B	285	RING-type.						nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			GGGGTGGCCCGGAAGTGCTCC	0.557													18	85					0	0	0	0	A	98828638	A	A	98828638	3	1	84	1	0	0	0	0	1	0	0	0	13493	1115	39	1	123	1	RNF113B	13	98828638	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	185946	98828638	16341240	272	16840											
NALCN	259232	broad.mit.edu	37	chr13	101762992	101762992	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgagtcaaagtttcaagaGattttcccctgctgatcctc	9	14	7	11	0	2	3	2	2	0	1	5	4	4	3	3	0	1	2	3	0	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr13:101762992G>T	uc001vox.1	-	20	2531	c.2342C>A	c.(2341-2343)TCT>TAT	p.S781Y		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	781	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGTTTCAAGAGATTTTCCCCT	0.383													23	64					6.12954e-19	1.06101e-18	1	0	T	101762992	T	T	101762992	3	4	84	1	0	0	0	0	1	0	0	0	10201	942	33	2	2974	2	NALCN	13	101762992	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2934354	101762992	13406886	273	16841											
MYO16	23026	broad.mit.edu	37	chr13	109379876	109379876	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggatgaagacttctggacgcCcatgcacattgcctgtgcct	8	10	11	12	1	1	2	0	1	1	1	1	4	1	4	3	2	3	1	3	2	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr13:109379876C>A	uc001vqt.1	+	4	512	c.386C>A	c.(385-387)CCC>CAC	p.P129H	MYO16_uc010agk.1_Missense_Mutation_p.P151H	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	129	ANK 3.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTCTGGACGCCCATGCACATT	0.423													28	46					4.87955e-14	7.86905e-14	1	0	A	109379876	A	A	109379876	3	1	84	1	0	0	0	0	1	0	0	0	10117	623	22	4	396	4	MYO16	13	109379876	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	7616884	109379876	5790002	274	16842											
MYH6	4624	broad.mit.edu	37	chr14	23870013	23870013	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgatgcgcgtcaccatccAgttgaacatcttctcataca	10	12	7	12	2	3	2	2	2	2	0	5	2	4	2	2	0	3	2	2	0	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr14:23870013A>T	uc001wjv.2	-	13	1382	c.1315T>A	c.(1315-1317)TGG>AGG	p.W439R	MYH6_uc010akp.1_Missense_Mutation_p.W439R	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	439	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GTCACCATCCAGTTGAACATC	0.567													34	54					0	0	0	0	T	23870013	T	T	23870013	3	4	84	1	0	0	0	0	1	0	0	0	10091	188	7	5	4612	5	MYH6	14	23870013	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08		23870013	83479527	275	16843											
NYNRIN	57523	broad.mit.edu	37	chr14	24877130	24877130	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagaggttcgctacccacCgatcctgcactgtgccttcc	8	9	9	15	2	0	1	0	0	0	1	3	3	2	1	5	1	3	3	5	1	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr14:24877130C>T	uc001wpf.3	+	3	572	c.254C>T	c.(253-255)CCG>CTG	p.P85L		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	85					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						CGCTACCCACCGATCCTGCAC	0.632													22	92					0	0	0	0	T	24877130	T	T	24877130	3	4	84	1	0	0	0	0	1	0	0	0	10850	652	23	1	260	1	NYNRIN	14	24877130	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1007117	24877130	82472410	276	16844											
NAA30	122830	broad.mit.edu	37	chr14	57866573	57866573	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttggttaagaaagctatatAtgccatggttgagggagact	12	12	12	5	0	0	3	0	1	0	2	0	4	0	3	1	3	2	3	1	3	5	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr14:57866573A>G	uc001xcx.3	+	4	1077	c.923A>G	c.(922-924)TAT>TGT	p.Y308C	NAA30_uc010trk.1_Missense_Mutation_p.Y50C|NAA30_uc010aow.2_Intron	NM_001011713	NP_001011713	Q147X3	NAA30_HUMAN	N-acetyltransferase 12	308	N-acetyltransferase.					cytoplasm	peptide alpha-N-acetyltransferase activity			skin(1)	1						AAAGCTATATATGCCATGGTT	0.264													59	57					0	0	0	0	G	57866573	G	G	57866573	3	3	84	1	0	0	0	0	1	0	0	0	10175	449	16	5	933	5	NAA30	14	57866573	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	32989443	57866573	49482967	277	16845											
SLC38A6	145389	broad.mit.edu	37	chr14	61519120	61519120	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggaattttagtttagcactCatcatttttgattggattaa	11	18	8	4	0	2	1	2	1	0	0	2	3	2	3	0	2	1	2	0	2	4	8			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr14:61519120C>G	uc001xfg.1	+	16	1460	c.1344C>G	c.(1342-1344)CTC>CTG	p.L448L	SLC38A6_uc001xfh.1_Intron|SLC38A6_uc001xfi.2_RNA|SLC38A6_uc001xfj.1_RNA|SLC38A6_uc001xfk.2_RNA|SLC38A6_uc010trz.1_Intron	NM_153811	NP_722518	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	448	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		GTTTAGCACTCATCATTTTTG	0.254													4	9					0	0	0	0	G	61519120	G	G	61519120	2	3	84	1	0	0	0	0	0	0	0	1	14672	813	29	2		2	SLC38A6	14	61519120	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3652547	61519120	45830420	278	16846											
NRXN3	9369	broad.mit.edu	37	chr14	79933568	79933568	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccttgcttttgcagctggCgctacgtacatctttgggaa	6	14	10	11	2	1	0	0	0	1	0	2	1	2	1	1	2	5	5	1	2	3	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr14:79933568C>T	uc001xun.2	+	13	2639	c.2148C>T	c.(2146-2148)GGC>GGT	p.G716G	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Silent_p.G84G|NRXN3_uc010asw.2_Silent_p.G84G|NRXN3_uc001xur.3_Silent_p.G84G	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1089	Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TTGCAGCTGGCGCTACGTACA	0.557													8	27					0	0	0	0	T	79933568	T	T	79933568	2	4	84	1	0	0	0	0	0	0	0	1	10721	755	27	1		1	NRXN3	14	79933568	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	18414448	79933568	27415972	279	16847											
NDN	4692	broad.mit.edu	37	chr15	23931618	23931618	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggctccacgtatgggacGcgctggtacttcaggtaatt	7	10	14	10	4	1	0	1	0	0	0	2	1	2	1	1	5	1	5	1	5	3	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:23931618G>A	uc001ywk.2	-	1	833	c.747C>T	c.(745-747)CGC>CGT	p.R249R		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	249	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CGTATGGGACGCGCTGGTACT	0.587									Prader-Willi_syndrome				20	21					0	0	0	0	A	23931618	A	A	23931618	2	1	84	1	0	0	0	0	0	0	0	1	10301	1074	38	1		1	NDN	15	23931618	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08		23931618	78599774	280	16848											
C15orf2	23742	broad.mit.edu	37	chr15	24921238	24921238	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taagaggccgtgtcctctccCtcgggctgcggccgcccctc	3	8	12	18	4	1	1	0	0	1	1	5	1	2	1	6	3	1	1	6	3	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:24921238C>A	uc001ywo.2	+	1	698	c.224C>A	c.(223-225)CCT>CAT	p.P75H		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	75					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TGTCCTCTCCCTCGGGCTGCG	0.711													13	35					4.36969e-10	6.73969e-10	1	0	A	24921238	A	A	24921238	3	1	84	1	0	0	0	0	1	0	0	0	1790	681	24	4	226	4	C15orf2	15	24921238	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	989620	24921238	77610154	281	16849											
C15orf2	23742	broad.mit.edu	37	chr15	24923722	24923722	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctctcattccacacttggggCcactgatgggcagcagaagt	9	9	11	12	0	1	2	1	1	1	1	3	2	2	2	2	3	1	2	2	3	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:24923722C>A	uc001ywo.2	+	1	3182	c.2708C>A	c.(2707-2709)GCC>GAC	p.A903D		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	903					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		ACACTTGGGGCCACTGATGGG	0.498													75	92					1.15773e-35	2.15007e-35	1	0	A	24923722	A	A	24923722	3	1	84	1	0	0	0	0	1	0	0	0	1790	739	26	4	2710	4	C15orf2	15	24923722	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2484	24923722	77607670	282	16850											
SNURF	8926	broad.mit.edu	37	chr15	25213119	25213119	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gttctcagcagcagcaagtaCctgtggtggatttccaggct	8	11	12	10	0	1	0	1	0	1	0	3	1	2	1	2	3	4	6	2	3	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:25213119C>A	uc001ywu.2	+	3	277	c.151C>A	c.(151-153)CCT>ACT	p.P51T	SNRPN_uc001ywp.1_5'UTR|SNRPN_uc001ywq.1_5'UTR|SNRPN_uc001ywr.1_5'UTR|SNRPN_uc001yws.1_Intron|SNRPN_uc001ywt.1_5'UTR|SNRPN_uc001ywv.1_5'UTR|SNRPN_uc001yww.1_5'UTR|SNRPN_uc001ywx.1_5'UTR|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_RNA|SNRPN_uc001ywy.1_Missense_Mutation_p.P51T	NM_022804	NP_073715	Q9Y675	SNURF_HUMAN	SNRPN upstream reading frame protein	51						nucleus					0		all_cancers(20;1.4e-21)|Breast(32;0.000625)		all cancers(64;3.48e-07)|Epithelial(43;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0142)		GCAGCAAGTACCTGTGGTGGA	0.433													41	70					1.3203e-36	2.48092e-36	1	0	A	25213119	A	A	25213119	3	1	84	1	0	0	0	0	1	0	0	0	14942	507	18	4	161	4	SNURF	15	25213119	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	289397	25213119	77318273	283	16851											
ATP10A	57194	broad.mit.edu	37	chr15	25940151	25940151	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgatcacgaggctgggtctgCggccagaggcagtggacgtg	7	6	18	10	4	2	1	1	0	1	1	2	4	2	2	1	5	1	2	1	5	0	0	rs150976669		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:25940151C>T	uc010ayu.2	-	14	3009	c.2903G>A	c.(2902-2904)CGC>CAC	p.R968H		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	968	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCTGGGTCTGCGGCCAGAGGC	0.602													10	66					0	0	0	0	T	25940151	T	T	25940151	3	4	84	1	0	0	0	0	1	0	0	0	1118	768	27	1	1628	1	ATP10A	15	25940151	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	727032	25940151	76591241	284	16852											
APBA2	321	broad.mit.edu	37	chr15	29406125	29406125	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgagcgagggggcgtccGtgtgggccaccgcatcatcg	5	7	17	12	5	1	1	1	1	0	0	3	2	2	1	3	3	2	2	3	3	0	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:29406125G>T	uc001zck.2	+	13	2291	c.2084G>T	c.(2083-2085)CGT>CTT	p.R695L	APBA2_uc010uat.1_Missense_Mutation_p.R683L|APBA2_uc001zcl.2_Missense_Mutation_p.R683L	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	695	PDZ 2.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGGGGCGTCCGTGTGGGCCAC	0.627													19	31					2.54575e-18	4.35925e-18	1	0	T	29406125	T	T	29406125	3	4	84	1	0	0	0	0	1	0	0	0	757	1145	40	3	2126	3	APBA2	15	29406125	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3465974	29406125	73125267	285	16853											
NDUFAF1	51103	broad.mit.edu	37	chr15	41688684	41688684	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggctcctgggcctcacctaCccttggaatcctggatatca	7	11	9	14	0	2	0	2	0	0	0	4	2	4	2	5	4	1	1	5	4	3	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:41688684C>A	uc001znx.2	-	2	955	c.573_splice	c.e2+1	p.R191_splice	NDUFAF1_uc010bcf.2_Splice_Site	NM_016013	NP_057097	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha						mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			ovary(1)	1		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		GCCTCACCTACCCTTGGAATC	0.468													19	34					1.67942e-08	2.49368e-08	1	0	A	41688684	A	A	41688684	5	1	84	1	0	0	0	0	0	0	1	0	10328	521	18	4	425	4	NDUFAF1	15	41688684	Splice_Site	SNP	C	TCGA-CN-6992-01A-11D-1912-08	12282559	41688684	60842708	286	16854											
SPTBN5	51332	broad.mit.edu	37	chr15	42168381	42168381	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcttcgtgccgcttgagTgtctgcaggatgtttctgcg	3	14	14	10	3	2	1	0	1	2	0	3	2	2	2	1	1	4	5	1	1	0	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:42168381T>A	uc001zos.2	-	21	4281	c.3948A>T	c.(3946-3948)ACA>ACT	p.T1316T		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1351	Spectrin 10.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCCGCTTGAGTGTCTGCAGGA	0.637													8	23					0	0	0	0	A	42168381	A	A	42168381	2	1	84	1	0	0	0	0	0	0	0	1	15188	1683	59	5		5	SPTBN5	15	42168381	Silent	SNP	T	TCGA-CN-6992-01A-11D-1912-08	479697	42168381	60363011	287	16855											
STRC	161497	broad.mit.edu	37	chr15	43910166	43910166	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgagttggggtaggggggccCccaggaactaaggctcccag	8	5	17	11	1	0	0	0	0	0	0	1	2	1	1	3	7	1	3	3	7	3	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:43910166C>A	uc001zsf.2	-	2	531	c.453G>T	c.(451-453)GGG>GGT	p.G151G	STRC_uc010bdl.2_5'UTR|STRC_uc010udz.1_RNA|STRC_uc001zsg.1_Silent_p.G77G	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	151					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TAGGGGGGCCCCCAGGAACTA	0.637													22	76					2.98393e-07	4.36957e-07	1	0	A	43910166	A	A	43910166	2	1	84	1	0	0	0	0	0	0	0	1	15394	610	22	4		4	STRC	15	43910166	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1741785	43910166	58621226	288	16856											
UNC13C	440279	broad.mit.edu	37	chr15	54306698	54306698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattatgcagatgcaacacCtctctggcactcacagagtg	11	9	8	13	0	2	2	1	0	1	2	3	2	2	2	2	1	3	3	2	1	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:54306698C>T	uc002ack.2	+	1	1598	c.1598C>T	c.(1597-1599)CCT>CTT	p.P533L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	533					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GATGCAACACCTCTCTGGCAC	0.358													20	30					0	0	0	0	T	54306698	T	T	54306698	3	4	84	1	0	0	0	0	1	0	0	0	17054	681	24	4	1600	4	UNC13C	15	54306698	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	10396532	54306698	48224694	289	16857											
TCF12	6938	broad.mit.edu	37	chr15	57574756	57574756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacccatcctgggcttagtGaaactaccaaccctatgggt	11	9	9	12	0	0	1	0	1	0	0	1	2	1	1	4	2	4	1	4	2	6	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:57574756G>A	uc002aec.2	+	19	2304	c.2020G>A	c.(2020-2022)GAA>AAA	p.E674K	TCF12_uc010ugm.1_Intron|TCF12_uc010ugn.1_Missense_Mutation_p.E694K|TCF12_uc002aea.2_Missense_Mutation_p.E698K|TCF12_uc010bfs.2_Missense_Mutation_p.E95K|TCF12_uc002aeb.2_Missense_Mutation_p.E698K|TCF12_uc002aed.2_Missense_Mutation_p.E674K|TCF12_uc002aee.2_Missense_Mutation_p.E504K|TCF12_uc010bft.2_Missense_Mutation_p.E528K|TCF12_uc010ugo.1_Missense_Mutation_p.E438K|TCF12_uc010ugp.1_Missense_Mutation_p.E331K|TCF12_uc010ugq.1_Missense_Mutation_p.E308K	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	674					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		TGGGCTTAGTGAAACTACCAA	0.468			T	TEC	extraskeletal myxoid chondrosarcoma								25	124					0	0	0	0	A	57574756	A	A	57574756	3	1	84	1	0	0	0	0	1	0	0	0	15753	1291	45	2	2239	2	TCF12	15	57574756	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3268058	57574756	44956636	290	16858											
CILP	8483	broad.mit.edu	37	chr15	65489842	65489842	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agggtcatcttcgttgaaggGgactgtgttgtagtcatatc	8	14	13	6	1	3	1	2	1	1	0	5	2	3	2	0	3	0	3	0	3	3	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:65489842G>A	uc002aon.2	-	9	2963	c.2782C>T	c.(2782-2784)CCC>TCC	p.P928S		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	928					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TCGTTGAAGGGGACTGTGTTG	0.522													35	64					0	0	0	0	A	65489842	A	A	65489842	3	1	84	1	0	0	0	0	1	0	0	0	3444	1232	43	4	776	4	CILP	15	65489842	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	7915086	65489842	37041550	291	16859											
HCN4	10021	broad.mit.edu	37	chr15	73621967	73621967	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactggatgagggcagtggCgtggccaatgaacatggcgt	9	7	18	7	2	0	2	0	2	0	0	0	4	0	4	1	6	1	1	1	6	2	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:73621967C>T	uc002avp.2	-	4	2531	c.1537G>A	c.(1537-1539)GCC>ACC	p.A513T		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	513	Helical; Name=Segment S6; (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		AGGGCAGTGGCGTGGCCAATG	0.652													12	61					0	0	0	0	T	73621967	T	T	73621967	3	4	84	1	0	0	0	0	1	0	0	0	7038	768	27	1	2094	1	HCN4	15	73621967	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	8132125	73621967	28909425	292	16860											
C15orf59	388135	broad.mit.edu	37	chr15	74032915	74032915	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtgctgctcacagtggcCgtggtccagtcgtccggctc	4	9	15	13	3	1	0	1	0	0	0	5	1	3	0	3	4	2	3	3	4	0	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:74032915C>T	uc002avy.2	-	2	570	c.225G>A	c.(223-225)ACG>ACA	p.T75T		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	75										pancreas(1)	1						TCACAGTGGCCGTGGTCCAGT	0.592													88	129					0	0	0	0	T	74032915	T	T	74032915	2	4	84	1	0	0	0	0	0	0	0	1	1813	639	23	1		1	C15orf59	15	74032915	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	410948	74032915	28498477	293	16861											
SCAMP2	10066	broad.mit.edu	37	chr15	75142867	75142867	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcactcacctaaaggccttaTagatgggtcggtaccaacaa	13	9	8	11	1	2	1	2	0	0	1	3	1	2	1	3	3	2	1	3	3	7	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:75142867T>C	uc002azb.1	-	6	694	c.620A>G	c.(619-621)TAT>TGT	p.Y207C	SCAMP2_uc002aza.1_Missense_Mutation_p.Y57C|SCAMP2_uc010bkg.1_Intron	NM_005697	NP_005688	O15127	SCAM2_HUMAN	secretory carrier membrane protein 2	207	Cytoplasmic (Potential).|Interaction with SLC9A7.				post-Golgi vesicle-mediated transport|protein transport	integral to membrane|nucleus|recycling endosome membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						AAAGGCCTTATAGATGGGTCG	0.562													4	157					0	0	0	0	C	75142867	C	C	75142867	3	2	84	1	0	0	0	0	1	0	0	0	13936	1406	49	5	385	5	SCAMP2	15	75142867	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	1109952	75142867	27388525	294	16862											
HOMER2	9455	broad.mit.edu	37	chr15	83527813	83527813	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaatcttcagcttgtcattCtcagacttcaggtgtgtgtt	7	16	9	9	0	5	1	4	0	2	1	6	1	5	1	0	1	1	3	0	1	1	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:83527813C>G	uc002bjg.2	-	5	681	c.495G>C	c.(493-495)GAG>GAC	p.E165D	HOMER2_uc002bjh.2_Missense_Mutation_p.E154D|HOMER2_uc002bjj.2_Missense_Mutation_p.E154D|HOMER2_uc002bji.2_Missense_Mutation_p.E165D	NM_199330	NP_955362	Q9NSB8	HOME2_HUMAN	homer 2 isoform 2	165	Potential.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane					0						GCTTGTCATTCTCAGACTTCA	0.507													5	196					0	0	0	0	G	83527813	G	G	83527813	3	3	84	1	0	0	0	0	1	0	0	0	7318	912	32	2	589	2	HOMER2	15	83527813	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	8384946	83527813	19003579	295	16863											
AGBL1	123624	broad.mit.edu	37	chr15	86838537	86838537	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcaaagaggtctacttcCggcaagatgttctctgccag	10	10	9	12	1	3	2	1	0	2	2	5	2	4	2	3	2	2	2	3	2	3	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:86838537C>T	uc002blz.1	+	16	2214	c.2134C>T	c.(2134-2136)CGG>TGG	p.R712W	AGBL1_uc002bma.1_Missense_Mutation_p.R443W|AGBL1_uc002bmb.1_Missense_Mutation_p.R406W	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	712					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GGTCTACTTCCGGCAAGATGT	0.468													11	86					0	0	0	0	T	86838537	T	T	86838537	3	4	84	1	0	0	0	0	1	0	0	0	375	643	23	1	2192	1	AGBL1	15	86838537	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3310724	86838537	15692855	296	16864											
CRTC3	64784	broad.mit.edu	37	chr15	91162992	91162992	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattcagtccctgtcaggacGccctcgatcctgtgatgttg	6	12	11	12	2	2	1	2	1	0	0	5	4	4	2	3	1	0	1	3	1	0	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:91162992G>A	uc002bpp.2	+	9	825	c.719G>A	c.(718-720)CGC>CAC	p.R240H	CRTC3_uc002bpo.2_Missense_Mutation_p.R240H	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	240					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CTGTCAGGACGCCCTCGATCC	0.443			T	MAML2	salivary gland mucoepidermoid								13	123					0	0	0	0	A	91162992	A	A	91162992	3	1	84	1	0	0	0	0	1	0	0	0	3916	1087	38	1	753	1	CRTC3	15	91162992	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	4324455	91162992	11368400	297	16865											
IGF1R	3480	broad.mit.edu	37	chr15	99434760	99434760	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtggaccgtgacttctgcGccaacatcctcagcgccgag	7	8	12	14	4	2	1	1	1	1	0	3	3	3	2	4	1	3	0	4	1	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr15:99434760G>A	uc002bul.2	+	3	897	c.847G>A	c.(847-849)GCC>ACC	p.A283T	IGF1R_uc010urq.1_Missense_Mutation_p.A283T|IGF1R_uc010bon.2_Missense_Mutation_p.A283T	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	283					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TGACTTCTGCGCCAACATCCT	0.637													11	70					0	0	0	0	A	99434760	A	A	99434760	3	1	84	1	0	0	0	0	1	0	0	0	7610	1087	38	1	857	1	IGF1R	15	99434760	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	8271768	99434760	3096632	298	16866											
APOB48R	55911	broad.mit.edu	37	chr16	28506849	28506850	+	Frame_Shift_Ins	INS	-	A	A																															ccaggagaggcaggagtcccINSatgagcaggaagtgaacaga																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr16:28506849_28506850insA	uc002dqb.1	+	2	497_498	c.487_488insA	c.(487-489)CATfs	p.H163fs	uc010vct.1_Intron|APOB48R_uc010byg.1_Translation_Start_Site	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	163	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						GCAGGAGTCCCATGAGCAGGAA	0.619													---	---	---								A	28506850	A	A	28506849	7	5	84	1	0	1	1	0	0	0	0	0	786	594	21	0	493	0	APOB48R	16	28506849	Frame_Shift_Ins	INS	-	TCGA-CN-6992-01A-11D-1912-08		28506849	61847904	299	16867											
ZNF646	9726	broad.mit.edu	37	chr16	31088376	31088376	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggtacaaatgtagtcagtGtggcaagacctacaagcacg	13	7	12	9	2	1	1	1	0	0	1	1	1	1	1	1	2	3	4	1	2	6	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr16:31088376G>A	uc002eap.2	+	2	1020	c.731G>A	c.(730-732)TGT>TAT	p.C244Y	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	244	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						TGTAGTCAGTGTGGCAAGACC	0.582													6	46					0	0	0	0	A	31088376	A	A	31088376	3	1	84	1	0	0	0	0	1	0	0	0	18129	1377	48	4	733	4	ZNF646	16	31088376	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	2581527	31088376	59266377	300	16868											
ITGAM	3684	broad.mit.edu	37	chr16	31308840	31308840	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgtctctttcagatcggCgcctacttcggggcctccct	3	13	9	16	3	2	1	1	0	1	1	7	1	4	1	4	3	1	0	4	3	1	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr16:31308840C>T	uc002ebq.2	+	13	1460	c.1362C>T	c.(1360-1362)GGC>GGT	p.G454G	ITGAM_uc002ebr.2_Silent_p.G454G|ITGAM_uc010cam.1_Missense_Mutation_p.R58C|ITGAM_uc010can.2_5'UTR	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	454	FG-GAP 5.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						TTCAGATCGGCGCCTACTTCG	0.582													27	168					0	0	0	0	T	31308840	T	T	31308840	2	4	84	1	0	0	0	0	0	0	0	1	7926	755	27	1		1	ITGAM	16	31308840	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	220464	31308840	59045913	301	16869											
LONP2	83752	broad.mit.edu	37	chr16	48295405	48295405	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagatgaagatgaagatgAagataatgatgacattgtca	19	9	11	2	0	1	10	1	5	0	5	1	10	1	10	0	0	0	0	0	0	5	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr16:48295405A>T	uc002efi.1	+	5	883	c.794A>T	c.(793-795)GAA>GTA	p.E265V	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.E221V	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	265					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						GATGAAGATGAAGATAATGAT	0.353													34	91					0	0	0	0	T	48295405	T	T	48295405	3	4	84	1	0	0	0	0	1	0	0	0	8943	246	9	5	812	5	LONP2	16	48295405	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	16986565	48295405	42059348	302	16870											
FAM65A	79567	broad.mit.edu	37	chr16	67574374	67574374	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aactcagggctggctggcttCgccaggctgtgtgtaggcga	6	9	16	10	2	1	0	1	0	0	0	2	1	1	0	1	5	1	5	1	5	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr16:67574374C>T	uc010vjp.1	+	9	801	c.705C>T	c.(703-705)TTC>TTT	p.F235F	FAM65A_uc010cei.1_Silent_p.F57F|FAM65A_uc002eth.2_Silent_p.F215F|FAM65A_uc010cej.2_Silent_p.F218F|FAM65A_uc002eti.1_Silent_p.F178F|FAM65A_uc010vjq.1_Silent_p.F229F|FAM65A_uc002etj.1_Silent_p.F214F|FAM65A_uc002etk.2_Silent_p.F214F	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	219						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		TGGCTGGCTTCGCCAGGCTGT	0.592													16	60					0	0	0	0	T	67574374	T	T	67574374	2	4	84	1	0	0	0	0	0	0	0	1	5631	883	31	1		1	FAM65A	16	67574374	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	19278969	67574374	22780379	303	16871											
LDHD	197257	broad.mit.edu	37	chr16	75146544	75146544	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgaccctgcccagttcctcGgcgtcatcagggttgaccag	6	10	11	14	2	2	2	2	2	0	0	4	2	3	2	4	2	1	2	4	2	0	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr16:75146544G>C	uc002fdm.2	-	10	1361	c.1314C>G	c.(1312-1314)GCC>GCG	p.A438A	LDHD_uc002fdn.2_Silent_p.A415A	NM_153486	NP_705690	Q86WU2	LDHD_HUMAN	D-lactate dehydrogenase isoform 1 precursor	438							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding				0						CCAGTTCCTCGGCGTCATCAG	0.607													13	39					0	0	0	0	C	75146544	C	C	75146544	2	2	84	1	0	0	0	0	0	0	0	1	8743	1103	39	3		3	LDHD	16	75146544	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	7572170	75146544	15208209	304	16872											
ZZEF1	23140	broad.mit.edu	37	chr17	3966057	3966057	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtacttacttggtaaaatCtttctgacaggtcagaagtt	11	16	8	6	0	3	2	1	1	2	1	3	2	3	2	0	2	2	3	0	2	5	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:3966057C>T	uc002fxe.2	-	30	4937	c.4873G>A	c.(4873-4875)GAT>AAT	p.D1625N	ZZEF1_uc002fxh.2_5'UTR|ZZEF1_uc002fxi.2_5'UTR|ZZEF1_uc002fxj.1_Missense_Mutation_p.D238N	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1625							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TTGGTAAAATCTTTCTGACAG	0.413													4	7					0	0	0	0	T	3966057	T	T	3966057	3	4	84	1	0	0	0	0	1	0	0	0	18322	913	32	2	4116	2	ZZEF1	17	3966057	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08		3966057	77229153	305	16873											
TNK1	8711	broad.mit.edu	37	chr17	7290420	7290420	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttgccagccacccgtccAgtccacagaggcacccctgc	7	5	10	19	1	0	1	0	0	0	1	2	1	2	1	7	2	3	2	7	2	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:7290420A>G	uc002ggi.3	+	9	1519	c.1359A>G	c.(1357-1359)CCA>CCG	p.P453P	TNK1_uc002ggj.3_Silent_p.P448P|TNK1_uc010cmf.2_RNA|TNK1_uc002ggk.3_Silent_p.P50P	NM_003985	NP_003976	Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	453					protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(122;0.157)				CCACCCGTCCAGTCCACAGAG	0.627													8	21					0	0	0	0	G	7290420	G	G	7290420	2	3	84	1	0	0	0	0	0	0	0	1	16383	175	7	5		5	TNK1	17	7290420	Silent	SNP	A	TCGA-CN-6992-01A-11D-1912-08	3324363	7290420	73904790	306	16874											
TP53	7157	broad.mit.edu	37	chr17	7576853	7576853	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtcccaagacttagtacCtgaagggtgaaatattctcc	12	10	10	9	0	1	3	0	2	1	1	3	4	2	3	3	2	1	1	3	2	6	4	rs11575996		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:7576853C>A	uc002gim.2	-	9	1187	c.993G>T	c.(991-993)CAG>CAT	p.Q331H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.Q331H|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Missense_Mutation_p.Q199H|TP53_uc010cng.1_Missense_Mutation_p.Q199H|TP53_uc002gii.1_Missense_Mutation_p.Q199H|TP53_uc010cnh.1_Missense_Mutation_p.Q331H|TP53_uc010cni.1_Missense_Mutation_p.Q331H|TP53_uc002gij.2_Missense_Mutation_p.Q331H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	331	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(14)|p.0?(7)|p.Q331P(3)|p.Q331fs*6(1)|p.I332fs*49(1)|p.?(1)|p.Q331Q(1)|p.Q331R(1)|p.Q331H(1)|p.Q331fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACTTAGTACCTGAAGGGTGA	0.453		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	42					3.62473e-10	5.61789e-10	1	0	A	7576853	A	A	7576853	3	1	84	1	0	0	0	0	1	0	0	0	16448	695	24	4	289	4	TP53	17	7576853	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	286433	7576853	73618357	307	16875											
TP53	7157	broad.mit.edu	37	chr17	7577535	7577535	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgatggtgaggatgggcCtccggttcatgccgcccatg	6	10	15	10	2	1	3	1	3	0	0	2	4	2	4	4	4	1	1	4	4	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:7577535C>A	uc002gim.2	-	7	940	c.746G>T	c.(745-747)AGG>ATG	p.R249M	TP53_uc002gig.1_Missense_Mutation_p.R249M|TP53_uc002gih.2_Missense_Mutation_p.R249M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R117M|TP53_uc010cng.1_Missense_Mutation_p.R117M|TP53_uc002gii.1_Missense_Mutation_p.R117M|TP53_uc010cnh.1_Missense_Mutation_p.R249M|TP53_uc010cni.1_Missense_Mutation_p.R249M|TP53_uc002gij.2_Missense_Mutation_p.R249M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R156M|TP53_uc002gio.2_Missense_Mutation_p.R117M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	249	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> I (in a sporadic cancer; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249S(303)|p.R249M(25)|p.R249G(24)|p.R249W(23)|p.R249T(16)|p.R249K(14)|p.0?(7)|p.R249R(6)|p.R249fs*96(6)|p.M246_P250delMNRRP(2)|p.R249fs*14(2)|p.R248_P250delRRP(1)|p.R249_P250delRP(1)|p.R249_P250insR(1)|p.R249_P250>SS(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*19(1)|p.R249_T256delRPILTIIT(1)|p.R249fs*15(1)|p.R249_I251delRPI(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGATGGGCCTCCGGTTCAT	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	31					1.85244e-09	2.81624e-09	1	0	A	7577535	A	A	7577535	3	1	84	1	0	0	0	0	1	0	0	0	16448	681	24	4	544	4	TP53	17	7577535	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	682	7577535	73617675	308	16876											
DNAH2	146754	broad.mit.edu	37	chr17	7727960	7727960	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatcctcatccatccttccGcctctggctcagctccatcc	5	11	6	19	1	3	0	2	0	1	0	9	1	9	1	7	2	1	2	7	2	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:7727960G>A	uc002giu.1	+	76	11782	c.11768G>A	c.(11767-11769)CGC>CAC	p.R3923H	DNAH2_uc010cnm.1_Missense_Mutation_p.R861H	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3923	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCATCCTTCCGCCTCTGGCTC	0.552													10	78					0	0	0	0	A	7727960	A	A	7727960	3	1	84	1	0	0	0	0	1	0	0	0	4624	1087	38	1	12070	1	DNAH2	17	7727960	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	150425	7727960	73467250	309	16877											
GUCY2D	3000	broad.mit.edu	37	chr17	7918083	7918083	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacacagatgctgcctccGtgggtgccagtgggaagggg	7	8	16	10	1	0	1	0	0	0	1	1	2	1	2	3	4	4	1	3	4	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:7918083G>T	uc002gjt.2	+	13	2650	c.2576_splice	c.e13+1	p.P859_splice		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)						intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				TGCTGCCTCCGTGGGTGCCAG	0.627													9	17					3.09899e-07	4.52765e-07	1	0	T	7918083	T	T	7918083	5	4	84	1	0	0	0	0	0	0	1	0	6936	1159	40	3	2623	3	GUCY2D	17	7918083	Splice_Site	SNP	G	TCGA-CN-6992-01A-11D-1912-08	190123	7918083	73277127	310	16878											
DNAH9	1770	broad.mit.edu	37	chr17	11687739	11687739	+	Frame_Shift_Del	DEL	C	-	-																															gcgtccctgcagaaatccatCcccccactgatcgatctggc																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:11687739delC	uc002gne.2	+	41	8012	c.7944delC	c.(7942-7944)ATCfs	p.I2648fs	DNAH9_uc010coo.2_Frame_Shift_Del_p.I1942fs	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2648	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGAAATCCATCCCCCCACTGA	0.532													---	---	---								-	11687739	-	-	11687739	7	5	84	1	0	1	0	1	0	0	0	0	4630	845	30	0	8106	0	DNAH9	17	11687739	Frame_Shift_Del	DEL	C	TCGA-CN-6992-01A-11D-1912-08	3769656	11687739	69507471	311	16879											
NCOR1	9611	broad.mit.edu	37	chr17	15942772	15942772	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggtgatgggtccccttcCtctcttcgtgtctcaccact	4	14	9	14	1	2	2	1	2	2	0	7	2	4	2	4	2	0	0	4	2	0	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:15942772C>G	uc002gpo.2	-	44	7170	c.6930G>C	c.(6928-6930)GAG>GAC	p.E2310D	NCOR1_uc002gpn.2_Missense_Mutation_p.E2207D|NCOR1_uc002gpl.2_Missense_Mutation_p.E325D|NCOR1_uc002gpm.2_Missense_Mutation_p.E830D|NCOR1_uc010vwb.1_Missense_Mutation_p.E894D|NCOR1_uc010coy.2_Missense_Mutation_p.E1218D	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2310	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GGTCCCCTTCCTCTCTTCGTG	0.468													10	35					0	0	0	0	G	15942772	G	G	15942772	3	3	84	1	0	0	0	0	1	0	0	0	10289	680	24	4	404	4	NCOR1	17	15942772	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	4255033	15942772	65252438	312	16880											
ZNF624	57547	broad.mit.edu	37	chr17	16550702	16550702	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatctggctgggtaacttCagggctctgatgggatacag	8	12	13	8	0	4	1	2	1	2	0	4	2	4	2	0	4	2	3	0	4	2	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:16550702C>G	uc010cpi.1	-	3	177	c.94G>C	c.(94-96)GAA>CAA	p.E32Q		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGGGTAACTTCAGGGCTCTGA	0.269													37	50					0	0	0	0	G	16550702	G	G	16550702	3	3	84	1	0	0	0	0	1	0	0	0	18115	835	29	2	2519	2	ZNF624	17	16550702	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	607930	16550702	64644508	313	16881											
MED24	9862	broad.mit.edu	37	chr17	38189629	38189629	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgccacactgctcggcctGactccggagctgcgggttgc	4	8	15	14	3	0	1	0	1	0	0	2	2	1	2	3	4	5	3	3	4	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:38189629G>T	uc002htt.2	-	7	953	c.640C>A	c.(640-642)CAG>AAG	p.Q214K	MED24_uc010wes.1_Missense_Mutation_p.Q74K|MED24_uc010wet.1_RNA|MED24_uc002hts.2_Missense_Mutation_p.Q239K|MED24_uc002htu.2_Missense_Mutation_p.Q201K|MED24_uc010cwn.2_Missense_Mutation_p.Q201K|MED24_uc010weu.1_Missense_Mutation_p.Q124K|MED24_uc010wev.1_Missense_Mutation_p.Q164K|MED24_uc010wew.1_Missense_Mutation_p.Q143K|MED24_uc010wex.1_Intron|MED24_uc010wez.1_Missense_Mutation_p.Q55K|MED24_uc010wfa.1_Missense_Mutation_p.Q183K|MED24_uc010wfb.1_Missense_Mutation_p.Q226K|MED24_uc010wfc.1_Missense_Mutation_p.Q170K	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	214					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					TGCTCGGCCTGACTCCGGAGC	0.592													10	3					9.70103e-10	1.48191e-09	1	0	T	38189629	T	T	38189629	3	4	84	1	0	0	0	0	1	0	0	0	9495	1299	45	2	2409	2	MED24	17	38189629	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	21638927	38189629	43005581	314	16882											
KRTAP4-9	100132386	broad.mit.edu	37	chr17	39262084	39262084	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgtgtgctgccagcccaaCtgctgccgccccagctgcag	5	8	11	17	1	1	0	0	0	1	0	1	0	1	0	5	0	8	4	5	0	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:39262084C>G	uc010wfp.1	+	1	444	c.444C>G	c.(442-444)AAC>AAG	p.N148K		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	148	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].|24.					keratin filament					0						gccagcccaactgctgccgcc	0.104													9	13					0	0	0	0	G	39262084	G	G	39262084	3	3	84	1	0	0	0	0	1	0	0	0	8597	564	20	4	446	4	KRTAP4-9	17	39262084	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1072455	39262084	41933126	315	16883											
KRT15	3866	broad.mit.edu	37	chr17	39673185	39673185	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccgttgatgtcagcctcaaCgccctggcgcagggccagct	6	7	13	15	3	2	1	2	1	0	0	2	1	2	1	4	2	3	3	4	2	1	1	rs138271368		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:39673185C>T	uc002hwy.2	-	3	804	c.613G>A	c.(613-615)GTT>ATT	p.V205I	KRT15_uc002hwz.2_Missense_Mutation_p.V107I|KRT15_uc002hxa.2_Missense_Mutation_p.V40I|KRT15_uc002hxb.1_Missense_Mutation_p.V40I	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	205	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				TCAGCCTCAACGCCCTGGCGC	0.612													19	65					0	0	0	0	T	39673185	T	T	39673185	3	4	84	1	0	0	0	0	1	0	0	0	8491	536	19	1	781	1	KRT15	17	39673185	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	411101	39673185	41522025	316	16884											
HSD17B1	3292	broad.mit.edu	37	chr17	40705593	40705593	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccagacatgaagaggcgcggTtcgggacgcgtgttggtgac	8	7	17	9	5	0	4	0	2	0	2	1	5	0	5	1	4	0	2	1	4	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:40705593T>C	uc002hzw.2	+	3	1370	c.402T>C	c.(400-402)GGT>GGC	p.G134G	HSD17B1_uc002hzx.2_Silent_p.G134G|HSD17B1_uc010wgm.1_RNA|uc002hzy.2_5'UTR|HSD17B1_uc010cyi.2_Silent_p.G165G	NM_000413	NP_000404	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	134					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity				0		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	AGAGGCGCGGTTCGGGACGCG	0.637													21	42					0	0	0	0	C	40705593	C	C	40705593	2	2	84	1	0	0	0	0	0	0	0	1	7417	1712	60	5		5	HSD17B1	17	40705593	Silent	SNP	T	TCGA-CN-6992-01A-11D-1912-08	1032408	40705593	40489617	317	16885											
MED13	9969	broad.mit.edu	37	chr17	60040139	60040139	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaacagtactcttgatatGaggaggaagagtctggacca	15	8	12	6	0	2	4	0	2	2	2	2	7	2	7	1	3	2	1	1	3	4	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:60040139G>T	uc002izo.2	-	21	5115	c.5038C>A	c.(5038-5040)CAT>AAT	p.H1680N		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1680					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						CTCTTGATATGAGGAGGAAGA	0.368													36	89					1.30091e-30	2.37444e-30	1	0	T	60040139	T	T	60040139	3	4	84	1	0	0	0	0	1	0	0	0	9483	1290	45	2	1526	2	MED13	17	60040139	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	19334546	60040139	21155071	318	16886											
SCN4A	6329	broad.mit.edu	37	chr17	62021165	62021165	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagcttcttcatggcgttatAgtatttcttctgttcctccg	6	18	7	10	2	4	0	1	0	3	0	6	0	6	0	2	1	1	4	2	1	4	8			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:62021165A>T	uc002jds.1	-	22	4035	c.3958T>A	c.(3958-3960)TAT>AAT	p.Y1320N		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1320					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	ATGGCGTTATAGTATTTCTTC	0.502													13	19					0	0	0	0	T	62021165	T	T	62021165	3	4	84	1	0	0	0	0	1	0	0	0	13985	420	15	5	1564	5	SCN4A	17	62021165	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	1981026	62021165	19174045	319	16887											
ERN1	2081	broad.mit.edu	37	chr17	62135335	62135335	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggtgcgttttctgaagtctGgtcaaccaggttgataacct	9	13	11	8	1	3	2	1	2	2	0	3	2	3	2	2	3	3	2	2	3	3	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:62135335G>C	uc002jdz.2	-	12	1338	c.1225C>G	c.(1225-1227)CAG>GAG	p.Q409E		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	409	Lumenal (Potential).				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						TCTGAAGTCTGGTCAACCAGG	0.552													5	6					0	0	0	0	C	62135335	C	C	62135335	3	2	84	1	0	0	0	0	1	0	0	0	5261	1357	47	4	1752	4	ERN1	17	62135335	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	114170	62135335	19059875	320	16888											
NUP85	79902	broad.mit.edu	37	chr17	73214330	73214330	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggtccggctccatgtgtgcGaggtggacagtttgtcggca	5	10	17	9	3	0	0	0	0	0	0	3	2	2	1	2	5	1	3	2	5	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:73214330G>A	uc002jng.1	+	7	786	c.526G>A	c.(526-528)GAG>AAG	p.E176K	NUP85_uc010dgd.1_Missense_Mutation_p.E176K|NUP85_uc010wrv.1_Missense_Mutation_p.E130K	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	176					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			CCATGTGTGCGAGGTGGACAG	0.572													7	64					0	0	0	0	A	73214330	A	A	73214330	3	1	84	1	0	0	0	0	1	0	0	0	10824	1059	37	1	552	1	NUP85	17	73214330	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	11078995	73214330	7980880	321	16889											
CANT1	124583	broad.mit.edu	37	chr17	76993210	76993211	+	Missense_Mutation	DNP	CA	AT	AT																															acaatcaggtcggatagctcCatgcctctccccttctccgc																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr17:76993210_76993211CA>AT	uc002jwn.2	-	4	933_934	c.494_495TG>AT	c.(493-495)ATG>AAT	p.M165N	CANT1_uc002jwk.2_Missense_Mutation_p.M165N|CANT1_uc002jwj.2_Missense_Mutation_p.M165N|CANT1_uc002jwl.2_RNA|CANT1_uc002jwm.1_5'Flank	NM_001159772	NP_001153244	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	165	Lumenal (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity				0			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			CGGATAGCTCCATGCCTCTCCC	0.599			T	ETV4	prostate								39	97					0	0	0	0	AT	76993211	AT	AT	76993210	3	1	84	1	0	0	0	0	1	0	0	0	2629	594	21	4	722	4	CANT1	17	76993210	Missense_Mutation	DNP	CA	TCGA-CN-6992-01A-11D-1912-08	3778880	76993210	4202000	322	16890											
EPB41L3	23136	broad.mit.edu	37	chr18	5416002	5416002	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcacaagggacggtgagcGgatcgggaggtaatgctgca	10	5	19	7	3	0	1	0	1	0	0	1	4	0	4	0	6	3	4	0	6	2	1	rs150101312		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr18:5416002G>A	uc002kmt.1	-	13	1968	c.1882C>T	c.(1882-1884)CGC>TGC	p.R628C	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Intron|EPB41L3_uc010wzf.1_Intron|EPB41L3_uc010wzg.1_Intron|EPB41L3_uc010dkr.2_Intron	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	628	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GACGGTGAGCGGATCGGGAGG	0.537													10	89					0	0	0	0	A	5416002	A	A	5416002	3	1	84	1	0	0	0	0	1	0	0	0	5178	1116	39	1	1421	1	EPB41L3	18	5416002	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08		5416002	72661246	323	16891											
MC5R	4161	broad.mit.edu	37	chr18	13826521	13826521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtttaccgtgtgctgggccCcgttcttccttcatctcact	3	16	8	14	2	3	0	2	0	2	0	5	0	4	0	4	1	2	3	4	1	1	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr18:13826521C>T	uc010xaf.1	+	1	757	c.757C>T	c.(757-759)CCG>TCG	p.P253S		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	253	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						GTGCTGGGCCCCGTTCTTCCT	0.577													50	64					0	0	0	0	T	13826521	T	T	13826521	3	4	84	1	0	0	0	0	1	0	0	0	9420	623	22	4	759	4	MC5R	18	13826521	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	8410519	13826521	64250727	324	16892											
CDH2	1000	broad.mit.edu	37	chr18	25572629	25572629	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaacacttactttgaccacgGtgactaacccgtcgttgctg	9	11	9	12	3	0	2	0	2	0	0	1	3	0	2	2	1	4	2	2	1	3	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr18:25572629G>C	uc002kwg.2	-	9	1793	c.1334C>G	c.(1333-1335)ACC>AGC	p.T445S	CDH2_uc010xbn.1_Missense_Mutation_p.T414S	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	445	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TTTGACCACGGTGACTAACCC	0.522													26	57					0	0	0	0	C	25572629	C	C	25572629	3	2	84	1	0	0	0	0	1	0	0	0	3120	1261	44	4	1418	4	CDH2	18	25572629	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	11746108	25572629	52504619	325	16893											
C18orf10	25941	broad.mit.edu	37	chr18	34376776	34376776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggaggggtgctcacttccGggtggggtttccagagccag	6	8	18	9	1	1	1	1	0	0	1	3	2	3	2	3	6	2	2	3	6	0	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr18:34376776G>A	uc002kzw.1	-	7	1323	c.895C>T	c.(895-897)CGG>TGG	p.R299W	C18orf10_uc002kzv.1_Intron|C18orf10_uc010xci.1_Missense_Mutation_p.R264W|C18orf10_uc002kzx.1_Missense_Mutation_p.R256W	NM_015476	NP_056291	Q68CL5	TPGS2_HUMAN	tubulin polyglutamylase complex subunit 2	299						cytoplasm|microtubule				skin(1)	1						GCTCACTTCCGGGTGGGGTTT	0.617													11	98					0	0	0	0	A	34376776	A	A	34376776	3	1	84	1	0	0	0	0	1	0	0	0	1904	1115	39	1	11	1	C18orf10	18	34376776	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	8804147	34376776	43700472	326	16894											
SETBP1	26040	broad.mit.edu	37	chr18	42531907	42531907	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaggagacgatccccagcGacagcggcattgggacagac	11	4	15	11	3	0	3	0	1	0	2	1	7	1	4	2	3	2	1	2	3	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr18:42531907G>T	uc010dni.2	+	4	2898	c.2602G>T	c.(2602-2604)GAC>TAC	p.D868Y		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	868			D -> N (in SGMFS).|D -> A (in SGMFS).			nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GATCCCCAGCGACAGCGGCAT	0.552									Schinzel-Giedion_syndrome				39	22					7.53189e-24	1.35532e-23	1	0	T	42531907	T	T	42531907	3	4	84	1	0	0	0	0	1	0	0	0	14194	1058	37	3	2805	3	SETBP1	18	42531907	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	8155131	42531907	35545341	327	16895											
ZNF236	7776	broad.mit.edu	37	chr18	74625839	74625839	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggggtcctcaagtcccacGagaagacacacacaggtcac	12	5	10	14	1	2	2	2	0	0	2	4	3	4	2	2	3	0	0	2	3	2	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr18:74625839G>A	uc002lmi.2	+	18	3238	c.3040G>A	c.(3040-3042)GAG>AAG	p.E1014K	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1014	C2H2-type 19.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CAAGTCCCACGAGAAGACACA	0.413													21	26					0	0	0	0	A	74625839	A	A	74625839	3	1	84	1	0	0	0	0	1	0	0	0	17856	1059	37	1	3110	1	ZNF236	18	74625839	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	32093932	74625839	3451409	328	16896											
DOT1L	84444	broad.mit.edu	37	chr19	2216357	2216357	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgtgtgccgcctgacgaCgccctgtccctgcacctgcg	3	9	11	18	4	0	1	0	1	0	0	2	2	2	1	6	0	3	1	6	0	0	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:2216357C>T	uc002lvb.3	+	20	2037	c.2001C>T	c.(1999-2001)GAC>GAT	p.D667D	DOT1L_uc002lvc.1_Translation_Start_Site|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_Translation_Start_Site	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	667						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCTGACGACGCCCTGTCCC	0.657													17	28					0	0	0	0	T	2216357	T	T	2216357	2	4	84	1	0	0	0	0	0	0	0	1	4731	535	19	1		1	DOT1L	19	2216357	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08		2216357	56912626	329	16897											
TLE6	79816	broad.mit.edu	37	chr19	2993528	2993528	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagcgggagccagcggcaCatggtggggcaaaaagacag	13	2	16	10	2	0	1	0	0	0	1	0	2	0	2	2	5	3	2	2	5	2	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:2993528C>T	uc002lwu.2	+	14	1516	c.1116C>T	c.(1114-1116)CAC>CAT	p.H372H	TLE6_uc002lwt.2_Silent_p.H495H|TLE6_uc010dtg.2_Silent_p.H495H|TLE6_uc002lwv.2_Silent_p.H276H	NM_024760	NP_079036	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 isoform 2	372	WD 5.				regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGCGGCACATGGTGGGGC	0.632													11	32					0	0	0	0	T	2993528	T	T	2993528	2	4	84	1	0	0	0	0	0	0	0	1	16008	477	17	4		4	TLE6	19	2993528	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	777171	2993528	56135455	330	16898											
ATCAY	85300	broad.mit.edu	37	chr19	3907911	3907911	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacatgaaagtggtcaccCacggaggtgagacccgcccc	10	6	11	14	2	1	2	1	2	0	1	1	4	1	3	4	3	1	0	4	3	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:3907911C>A	uc002lyy.3	+	5	968	c.538C>A	c.(538-540)CAC>AAC	p.H180N	ATCAY_uc010xhz.1_Missense_Mutation_p.H186N|ATCAY_uc010dts.2_5'Flank	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	180	CRAL-TRIO.				transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		AGTGGTCACCCACGGAGGTGA	0.667													7	16					0.00448238	0.00615361	1	0	A	3907911	A	A	3907911	3	1	84	1	0	0	0	0	1	0	0	0	1079	594	21	4	552	4	ATCAY	19	3907911	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	914383	3907911	55221072	331	16899											
LONP1	9361	broad.mit.edu	37	chr19	5711885	5711885	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggctccatcgccagctccGccgggtgcctggcgctcagc	3	7	14	17	4	1	0	1	0	0	0	4	0	3	0	5	3	3	3	5	3	0	0	rs116591583	byFrequency	TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:5711885G>A	uc002mcx.2	-	4	800	c.767C>T	c.(766-768)GCG>GTG	p.A256V	LONP1_uc002mcy.2_Missense_Mutation_p.A192V|LONP1_uc010duh.2_5'UTR|LONP1_uc010dui.2_Missense_Mutation_p.A256V|LONP1_uc002mcz.2_Missense_Mutation_p.A60V	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	256	Lon.				cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						CGCCAGCTCCGCCGGGTGCCT	0.667													18	43					0	0	0	0	A	5711885	A	A	5711885	3	1	84	1	0	0	0	0	1	0	0	0	8942	1087	38	1	2172	1	LONP1	19	5711885	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1803974	5711885	53417098	332	16900											
TNFSF9	8744	broad.mit.edu	37	chr19	6530990	6530990	+	5'Flank	DEL	T	-	-																															ggcggaggggcgtggcctccTtttgtagccaagcagctata																								rs2234172		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:6530990delT	uc002mfh.2	+							NM_003811	NP_003802	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily,						apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						CGTGGCCTCCTTTTGTAGCCA	0.667													---	---	---								-	6530990	-	-	6530990	6	5	84	0	1	1	0	1	0	0	0	0	16378	1624	56	0		0	TNFSF9	19	6530990	5'Flank	DEL	T	TCGA-CN-6992-01A-11D-1912-08	819105	6530990	52597993	333	16901											
EMR1	2015	broad.mit.edu	37	chr19	6913740	6913740	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccaaggaagagacgtcctCcctggccacagtcttcctgg	9	7	10	15	1	1	1	0	0	1	1	4	3	4	2	5	3	0	0	5	3	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:6913740C>T	uc002mfw.2	+	11	1237	c.1199C>T	c.(1198-1200)TCC>TTC	p.S400F	EMR1_uc010dvc.2_Missense_Mutation_p.S400F|EMR1_uc010dvb.2_Missense_Mutation_p.S348F|EMR1_uc010xji.1_Missense_Mutation_p.S259F|EMR1_uc010xjj.1_Missense_Mutation_p.S223F	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	400	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					GAGACGTCCTCCCTGGCCACA	0.463													51	74					0	0	0	0	T	6913740	T	T	6913740	3	4	84	1	0	0	0	0	1	0	0	0	5128	855	30	2	1241	2	EMR1	19	6913740	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	382750	6913740	52215243	334	16902											
PRAM1	84106	broad.mit.edu	37	chr19	8555792	8555792	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgaacttcttccggaactcCctctcggccttctctgcctt	4	15	6	16	2	3	1	0	1	3	0	7	2	5	2	4	2	3	0	4	2	2	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:8555792C>T	uc002mkd.2	-	6	1742	c.1722G>A	c.(1720-1722)AGG>AGA	p.R574R	PRAM1_uc002mkc.2_Silent_p.R573R	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	622	SH3.						lipid binding|protein binding				0						TCCGGAACTCCCTCTCGGCCT	0.592													10	258					0	0	0	0	T	8555792	T	T	8555792	2	4	84	1	0	0	0	0	0	0	0	1	12483	622	22	4		4	PRAM1	19	8555792	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1642052	8555792	50573191	335	16903											
MYO1F	4542	broad.mit.edu	37	chr19	8616943	8616943	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagatgtggaagttcctctCattttcattttgcatgacca	9	16	8	8	0	2	2	2	1	1	1	4	3	3	3	2	1	1	3	2	1	2	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:8616943C>G	uc002mkg.2	-	7	724	c.610G>C	c.(610-612)GAG>CAG	p.E204Q	MYO1F_uc002mkh.2_Missense_Mutation_p.E204Q|MYO1F_uc010xkf.1_Missense_Mutation_p.E204Q	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	204	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						AAGTTCCTCTCATTTTCATTT	0.572													26	48					0	0	0	0	G	8616943	G	G	8616943	3	3	84	1	0	0	0	0	1	0	0	0	10126	835	29	2	2774	2	MYO1F	19	8616943	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	61151	8616943	50512040	336	16904											
MUC16	94025	broad.mit.edu	37	chr19	8987085	8987085	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctgtgtaccgtgcacccaGgctgctcctctggaacaaag	8	8	11	14	1	1	0	0	0	1	0	2	1	2	1	4	2	4	4	4	2	3	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:8987085G>A	uc002mkp.2	-	69	42109	c.41905C>T	c.(41905-41907)CTG>TTG	p.L13969L	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.L786L|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CGTGCACCCAGGCTGCTCCTC	0.602													3	10					0	0	0	0	A	8987085	A	A	8987085	2	1	84	1	0	0	0	0	0	0	0	1	10026	991	35	4		4	MUC16	19	8987085	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	370142	8987085	50141898	337	16905											
MUC16	94025	broad.mit.edu	37	chr19	9047583	9047583	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgcaggatgagtaacccAtgaggctgttgcctctgatt	9	11	12	9	0	1	3	0	3	1	0	1	5	1	4	2	2	3	4	2	2	1	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:9047583A>G	uc002mkp.2	-	5	34252	c.34048T>C	c.(34048-34050)TGG>CGG	p.W11350R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11352	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGAGTAACCCATGAGGCTGTT	0.507													75	174					0	0	0	0	G	9047583	G	G	9047583	3	3	84	1	0	0	0	0	1	0	0	0	10026	217	8	5	9795	5	MUC16	19	9047583	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	60498	9047583	50081400	338	16906											
MUC16	94025	broad.mit.edu	37	chr19	9071740	9071740	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtggacttatcatggtctgGggtggaaattttgctagaag	9	14	14	4	0	2	1	1	0	1	1	2	3	2	3	0	5	1	1	0	5	4	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:9071740G>T	uc002mkp.2	-	3	15910	c.15706C>A	c.(15706-15708)CCA>ACA	p.P5236T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5238	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCATGGTCTGGGGTGGAAATT	0.473													36	77					9.65963e-10	1.48191e-09	1	0	T	9071740	T	T	9071740	3	4	84	1	0	0	0	0	1	0	0	0	10026	1232	43	4	28145	4	MUC16	19	9071740	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	24157	9071740	50057243	339	16907											
ZNF560	147741	broad.mit.edu	37	chr19	9577625	9577625	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgagttagtacacaagacctActgtaagctttttcacatgc	12	13	7	9	0	1	2	1	1	0	1	1	2	1	2	1	0	4	4	1	0	5	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:9577625A>T	uc002mlp.1	-	10	2208	c.1998T>A	c.(1996-1998)AGT>AGA	p.S666R	ZNF560_uc010dwr.1_Missense_Mutation_p.S560R	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	666	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						CACAAGACCTACTGTAAGCTT	0.388													50	76					0	0	0	0	T	9577625	T	T	9577625	3	4	84	1	0	0	0	0	1	0	0	0	18058	388	14	5	378	5	ZNF560	19	9577625	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	505885	9577625	49551358	340	16908											
ZNF426	79088	broad.mit.edu	37	chr19	9639320	9639320	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttctccagtgtggattcgCatgtgaattttaaggtgggt	7	17	12	5	1	1	1	0	1	1	0	3	2	1	2	1	3	0	1	1	3	2	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:9639320C>A	uc002mlq.2	-	8	1665	c.1401G>T	c.(1399-1401)ATG>ATT	p.M467I	ZNF426_uc010dws.2_Missense_Mutation_p.M429I	NM_024106	NP_077011	Q9BUY5	ZN426_HUMAN	zinc finger protein 426	467	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGTGGATTCGCATGTGAATTT	0.423													19	56					0.00121646	0.00168088	1	0	A	9639320	A	A	9639320	3	1	84	1	0	0	0	0	1	0	0	0	17967	710	25	4	267	4	ZNF426	19	9639320	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	61695	9639320	49489663	341	16909											
DNM2	1785	broad.mit.edu	37	chr19	10893759	10893759	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctaccggcacatggccgaccGcatgggcacgccacatctgc	8	5	11	17	4	1	0	0	0	1	0	1	1	1	0	4	3	2	3	4	3	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:10893759G>T	uc002mps.1	+	6	976	c.812G>T	c.(811-813)CGC>CTC	p.R271L	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Missense_Mutation_p.R271L|DNM2_uc002mpv.1_Missense_Mutation_p.R271L|DNM2_uc002mpu.1_Missense_Mutation_p.R271L|DNM2_uc010dxl.1_Missense_Mutation_p.R271L|DNM2_uc002mpw.2_Missense_Mutation_p.R4L	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	271					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			ATGGCCGACCGCATGGGCACG	0.577													19	40					1.45105e-14	2.35196e-14	1	0	T	10893759	T	T	10893759	3	4	84	1	0	0	0	0	1	0	0	0	4694	1087	38	3	834	3	DNM2	19	10893759	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1254439	10893759	48235224	342	16910											
MAN2B1	4125	broad.mit.edu	37	chr19	12767762	12767762	+	Splice_Site	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccctcccgtcccggctcaCgcgcgccgccgtctggctga	3	6	11	21	7	2	1	1	1	1	0	4	1	4	1	6	2	0	2	6	2	0	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:12767762C>G	uc002mub.2	-	12	1603	c.1527_splice	c.e12+1	p.R509_splice	MAN2B1_uc010dyv.1_Splice_Site_p.R508_splice	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1						protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						TCCCGGCTCACGCGCGCCGCC	0.572													8	12					0	0	0	0	G	12767762	G	G	12767762	5	3	84	1	0	0	0	0	0	0	1	0	9269	550	19	3	1559	3	MAN2B1	19	12767762	Splice_Site	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1874003	12767762	46361221	343	16911											
ASNA1	439	broad.mit.edu	37	chr19	12848400	12848400	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggagccgctggagcctacActtagcaacatcatcgagca	11	7	11	12	2	1	0	1	0	0	0	2	3	1	2	2	2	6	3	2	2	3	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:12848400A>C	uc002muv.2	+	1	95	c.81A>C	c.(79-81)ACA>ACC	p.T27T	C19orf43_uc002muu.2_5'Flank|ASNA1_uc002muw.2_Silent_p.T27T	NM_004317	NP_004308	O43681	ASNA_HUMAN	arsA arsenite transporter, ATP-binding, homolog	27					response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding			ovary(2)	2					Adenosine triphosphate(DB00171)	TGGAGCCTACACTTAGCAACA	0.627													7	14					0	0	0	0	C	12848400	C	C	12848400	2	2	84	1	0	0	0	0	0	0	0	1	1049	146	6	5		5	ASNA1	19	12848400	Silent	SNP	A	TCGA-CN-6992-01A-11D-1912-08	80638	12848400	46280583	344	16912											
C19orf44	84167	broad.mit.edu	37	chr19	16611661	16611661	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtttttggtgacttcagtGatgtttccttggaagattca	8	18	10	5	0	2	3	2	2	0	1	3	4	3	4	1	2	0	2	1	2	1	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:16611661G>A	uc002neh.1	+	2	131	c.58G>A	c.(58-60)GAT>AAT	p.D20N	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.D20N|C19orf44_uc002neg.2_Missense_Mutation_p.D20N|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	20											0						TGACTTCAGTGATGTTTCCTT	0.423													41	83					0	0	0	0	A	16611661	A	A	16611661	3	1	84	1	0	0	0	0	1	0	0	0	1936	1290	45	2	60	2	C19orf44	19	16611661	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3763261	16611661	42517322	345	16913											
GLT25D1	79709	broad.mit.edu	37	chr19	17688840	17688840	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgggacccctaccacggccGgcccctcaccaagggtgagc	7	3	12	19	3	1	1	1	1	0	0	1	2	1	2	8	4	2	0	8	4	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:17688840G>A	uc002nhc.1	+	9	1220	c.1208G>A	c.(1207-1209)CGG>CAG	p.R403Q	GLT25D1_uc010eax.1_Missense_Mutation_p.R131Q|GLT25D1_uc010eay.1_5'Flank	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	403					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0						TACCACGGCCGGCCCCTCACC	0.632													11	47					0	0	0	0	A	17688840	A	A	17688840	3	1	84	1	0	0	0	0	1	0	0	0	6503	1116	39	1	1242	1	GLT25D1	19	17688840	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1077179	17688840	41440143	346	16914											
KIAA1683	80726	broad.mit.edu	37	chr19	18368176	18368176	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccctccaggcggactggatGgctgtggccgctttgtcctg	3	10	14	14	2	0	0	0	0	0	0	2	2	2	2	5	5	0	2	5	5	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:18368176G>A	uc002nin.2	-	4	3573	c.3357C>T	c.(3355-3357)GCC>GCT	p.A1119A	PDE4C_uc002nil.3_5'Flank|KIAA1683_uc010ebn.2_Silent_p.A1306A|KIAA1683_uc010xqe.1_Silent_p.A1073A|KIAA1683_uc010xqf.1_RNA	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	1119	IQ 5.					mitochondrion				ovary(2)	2						CGGACTGGATGGCTGTGGCCG	0.652													19	40					0	0	0	0	A	18368176	A	A	18368176	2	1	84	1	0	0	0	0	0	0	0	1	8290	1335	47	4		4	KIAA1683	19	18368176	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	679336	18368176	40760807	347	16915											
ARMC6	93436	broad.mit.edu	37	chr19	19166617	19166617	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caggtgtgtgagcagagctgCgcggccctgtgcttcctggc	4	9	16	12	2	0	2	0	1	0	1	1	2	1	2	2	3	4	3	2	3	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:19166617C>A	uc002nld.2	+	8	1521	c.1173C>A	c.(1171-1173)TGC>TGA	p.C391*	ARMC6_uc002nlc.2_Nonsense_Mutation_p.C366*|ARMC6_uc010xql.1_Nonsense_Mutation_p.C298*|ARMC6_uc002nle.2_Nonsense_Mutation_p.C366*|ARMC6_uc010xqm.1_Nonsense_Mutation_p.C391*	NM_033415	NP_219483	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	391	ARM 4.						protein binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			AGCAGAGCTGCGCGGCCCTGT	0.642													59	122					3.79397e-19	6.60316e-19	1	0	A	19166617	A	A	19166617	4	1	84	1	0	0	0	0	0	1	0	0	957	776	27	3	1120	3	ARMC6	19	19166617	Nonsense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	798441	19166617	39962366	348	16916											
NCAN	1463	broad.mit.edu	37	chr19	19349086	19349086	+	Frame_Shift_Del	DEL	G	-	-																															cgagggctgtgaccgcggctGgcataagttccagggccact																										TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:19349086delG	uc002nlz.2	+	11	3374	c.3275delG	c.(3274-3276)TGGfs	p.W1092fs	NCAN_uc010ecc.1_Frame_Shift_Del_p.W656fs|NCAN_uc002nma.2_5'Flank	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1092	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GACCGCGGCTGGCATAAGTTC	0.662													---	---	---								-	19349086	-	-	19349086	7	5	84	1	0	1	0	1	0	0	0	0	10258	1357	47	0	3313	0	NCAN	19	19349086	Frame_Shift_Del	DEL	G	TCGA-CN-6992-01A-11D-1912-08	182469	19349086	39779897	349	16917											
ZNF676	163223	broad.mit.edu	37	chr19	22364105	22364105	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttacatttcaaacctttCtctccagtatgccttatctt	8	19	2	12	0	4	0	1	0	3	0	6	0	5	0	3	0	3	1	3	0	4	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:22364105C>G	uc002nqs.1	-	3	732	c.414G>C	c.(412-414)GAG>GAC	p.E138D		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TCAAACCTTTCTCTCCAGTAT	0.323													11	121					0	0	0	0	G	22364105	G	G	22364105	3	3	84	1	0	0	0	0	1	0	0	0	18150	912	32	2	1356	2	ZNF676	19	22364105	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3015019	22364105	36764878	350	16918											
ZFP14	57677	broad.mit.edu	37	chr19	36832353	36832353	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccccctcaatcttgcttttGcattcccaatcattcctaaa	9	15	2	15	0	3	0	2	0	1	0	6	0	6	0	4	0	2	2	4	0	4	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:36832353G>T	uc002odx.1	-	4	468	c.375C>A	c.(373-375)TGC>TGA	p.C125*	ZFP14_uc010xtd.1_Nonsense_Mutation_p.C126*|ZFP14_uc010eex.1_Nonsense_Mutation_p.C125*	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					TCTTGCTTTTGCATTCCCAAT	0.343													15	72					1.37285e-15	2.25971e-15	1	0	T	36832353	T	T	36832353	4	4	84	1	0	0	0	0	0	1	0	0	17706	1311	46	4	1230	4	ZFP14	19	36832353	Nonsense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	14468248	36832353	22296630	351	16919											
ZNF260	339324	broad.mit.edu	37	chr19	37005104	37005104	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcatatgcacagtaagaGatgagctttgacagaaggct	13	11	10	7	0	1	4	1	2	1	2	2	5	1	4	0	1	2	4	0	1	3	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:37005104G>A	uc002oee.1	-	4	1881	c.1037C>T	c.(1036-1038)TCT>TTT	p.S346F	ZNF260_uc002oed.1_Missense_Mutation_p.S343F|ZNF260_uc010eey.1_Missense_Mutation_p.S343F|ZNF260_uc002oef.1_Missense_Mutation_p.S343F	NM_001012756	NP_001012774	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	346	C2H2-type 11.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					CACAGTAAGAGATGAGCTTTG	0.423													12	37					0	0	0	0	A	37005104	A	A	37005104	3	1	84	1	0	0	0	0	1	0	0	0	17869	942	33	2	205	2	ZNF260	19	37005104	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	172751	37005104	22123879	352	16920											
CRX	1406	broad.mit.edu	37	chr19	48342676	48342676	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccaaggcccggcctgccAagaggaaggcgggcacgtcc	9	2	16	14	3	0	1	0	0	0	1	1	2	1	2	5	6	1	1	5	6	3	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:48342676A>T	uc002phq.3	+	4	556	c.352A>T	c.(352-354)AAG>TAG	p.K118*		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	118					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		CCGGCCTGCCAAGAGGAAGGC	0.537													35	24					0	0	0	0	T	48342676	T	T	48342676	4	4	84	1	0	0	0	0	0	1	0	0	3917	131	5	5	362	5	CRX	19	48342676	Nonsense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	11337572	48342676	10786307	353	16921											
GYS1	2997	broad.mit.edu	37	chr19	49477910	49477910	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactgctattgaagaggccGattcggcggatggtggtcag	8	9	16	8	3	1	2	1	1	0	1	2	4	1	3	1	5	1	2	1	5	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:49477910G>T	uc002plp.2	-	11	1630	c.1389C>A	c.(1387-1389)ATC>ATA	p.I463I	GYS1_uc010xzy.1_Silent_p.I96I|GYS1_uc010emm.2_Silent_p.I399I|GYS1_uc010xzz.1_Silent_p.I383I|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	463					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TGAAGAGGCCGATTCGGCGGA	0.612													12	7					7.03913e-09	1.05753e-08	1	0	T	49477910	T	T	49477910	2	4	84	1	0	0	0	0	0	0	0	1	6951	1048	37	3		3	GYS1	19	49477910	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1135234	49477910	9651073	354	16922											
ZNF611	81856	broad.mit.edu	37	chr19	53209368	53209368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acactcattacaattgtaacGttttactccagtatgaagtc	13	14	5	9	1	1	1	1	1	0	0	3	1	2	1	1	0	3	3	1	0	6	6	rs146528210		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:53209368G>A	uc002pzz.2	-	7	1257	c.940C>T	c.(940-942)CGT>TGT	p.R314C	ZNF611_uc010eqc.2_Missense_Mutation_p.R244C|ZNF611_uc010ydo.1_Missense_Mutation_p.R244C|ZNF611_uc010ydr.1_Missense_Mutation_p.R245C|ZNF611_uc010ydp.1_Missense_Mutation_p.R314C|ZNF611_uc010ydq.1_Missense_Mutation_p.R314C|ZNF611_uc002qaa.3_Missense_Mutation_p.R244C	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		CAATTGTAACGTTTTACTCCA	0.398													5	77					0	0	0	0	A	53209368	A	A	53209368	3	1	84	1	0	0	0	0	1	0	0	0	18104	1145	40	1	1181	1	ZNF611	19	53209368	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3731458	53209368	5919615	355	16923											
NLRP12	91662	broad.mit.edu	37	chr19	54301518	54301518	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acagtttctggagtctgcagGcgggatgttgcagcccctca	7	10	13	11	1	3	0	1	0	2	0	3	2	3	2	2	3	3	4	2	3	0	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:54301518G>A	uc002qch.3	-	8	3126	c.2906C>T	c.(2905-2907)GCC>GTC	p.A969V	NLRP12_uc010eqw.2_Intron|NLRP12_uc002qci.3_Intron|NLRP12_uc002qcj.3_Missense_Mutation_p.A970V|NLRP12_uc002qck.3_Intron|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	969					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GAGTCTGCAGGCGGGATGTTG	0.582													17	16					0	0	0	0	A	54301518	A	A	54301518	3	1	84	1	0	0	0	0	1	0	0	0	10528	1203	42	4	291	4	NLRP12	19	54301518	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1092150	54301518	4827465	356	16924											
PRKCG	5582	broad.mit.edu	37	chr19	54401709	54401709	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cataggtgatgctggccgagCgcaggggctctgatgagctc	7	8	16	10	2	1	3	0	3	1	0	2	4	1	3	1	4	3	4	1	4	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:54401709C>G	uc002qcq.1	+	11	1390	c.1108C>G	c.(1108-1110)CGC>GGC	p.R370G	PRKCG_uc010yef.1_3'UTR|PRKCG_uc010yeg.1_Missense_Mutation_p.R370G|PRKCG_uc010yeh.1_Missense_Mutation_p.R257G	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	370	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		GCTGGCCGAGCGCAGGGGCTC	0.577													16	18					0	0	0	0	G	54401709	G	G	54401709	3	3	84	1	0	0	0	0	1	0	0	0	12574	768	27	3	1150	3	PRKCG	19	54401709	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	100191	54401709	4727274	357	16925											
LILRB2	10288	broad.mit.edu	37	chr19	54779807	54779807	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaggggcggggtctcacccGagtgtccatctccaccccat	7	7	11	16	2	2	0	1	0	2	0	5	1	3	0	5	4	0	0	5	4	0	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:54779807G>A	uc002qfb.2	-	13	1914	c.1648C>T	c.(1648-1650)CGG>TGG	p.R550W	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_3'UTR|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.R549W|LILRB2_uc010yet.1_Missense_Mutation_p.R434W	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	550	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGTCTCACCCGAGTGTCCATC	0.622													55	59					0	0	0	0	A	54779807	A	A	54779807	3	1	84	1	0	0	0	0	1	0	0	0	8832	1057	37	1	156	1	LILRB2	19	54779807	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	378098	54779807	4349176	358	16926											
KIR3DL1	3811	broad.mit.edu	37	chr19	55378058	55378058	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tacagagaaaaatcagtcgcCcttctcagaggcccaagaca	15	6	8	12	1	2	3	2	0	1	3	4	4	2	3	2	1	1	0	2	1	4	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:55378058C>A	uc002qhl.3	+	9	1303	c.1240C>A	c.(1240-1242)CCT>ACT	p.P414T	KIR3DL2_uc010esh.2_Missense_Mutation_p.P397T|KIR3DL2_uc002qho.3_Missense_Mutation_p.P414T			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	414	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		AATCAGTCGCCCTTCTCAGAG	0.522													114	97					9.4957e-49	1.81101e-48	1	0	A	55378058	A	A	55378058	3	1	84	1	0	0	0	0	1	0	0	0	8359	623	22	4		4	KIR3DL1	19	55378058	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	598251	55378058	3750925	359	16927											
ZNF274	10782	broad.mit.edu	37	chr19	58718244	58718244	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgctgaagatggaagcctGagtgcagatgcccccagtga	11	8	13	9	0	0	5	0	3	0	2	0	6	0	6	3	1	4	2	3	1	3	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr19:58718244G>A	uc002qrq.1	+	5	873	c.414G>A	c.(412-414)CTG>CTA	p.L138L	ZNF274_uc010yhu.1_RNA|ZNF274_uc010yhv.1_RNA|ZNF274_uc002qrr.1_Silent_p.L106L|ZNF274_uc002qrs.1_Silent_p.L33L|ZNF274_uc010eum.1_5'UTR	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	138					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		ATGGAAGCCTGAGTGCAGATG	0.577													4	15					0	0	0	0	A	58718244	A	A	58718244	2	1	84	1	0	0	0	0	0	0	0	1	17876	1277	45	2		2	ZNF274	19	58718244	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	3340186	58718244	410739	360	16928											
TPX2	22974	broad.mit.edu	37	chr20	30366776	30366776	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atatcatttgaggagcaagaAggatgatattagtaagtttc	15	13	10	3	0	1	3	1	2	0	1	2	5	1	5	0	2	1	3	0	2	6	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr20:30366776A>G	uc002wwp.1	+	10	1741	c.1043A>G	c.(1042-1044)AAG>AGG	p.K348R	TPX2_uc010gdv.1_Missense_Mutation_p.K348R	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	348					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			AGGAGCAAGAAGGATGATATT	0.403													5	31					0	0	0	0	G	30366776	G	G	30366776	3	3	84	1	0	0	0	0	1	0	0	0	16499	72	3	5	1073	5	TPX2	20	30366776	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08		30366776	32658744	361	16929											
TM9SF4	9777	broad.mit.edu	37	chr20	30749133	30749133	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggggctctgcattctacGtcctggtttatgccatcttt	4	15	10	12	2	3	0	0	0	3	0	4	0	4	0	3	3	3	3	3	3	2	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr20:30749133G>C	uc002wxj.2	+	17	1979	c.1744G>C	c.(1744-1746)GTC>CTC	p.V582L	TM9SF4_uc010zts.1_Missense_Mutation_p.V489L|TM9SF4_uc002wxk.2_Missense_Mutation_p.V565L|TM9SF4_uc010gdz.2_Missense_Mutation_p.V461L	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	582	Helical; (Potential).					integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TGCATTCTACGTCCTGGTTTA	0.517													28	45					0	0	0	0	C	30749133	C	C	30749133	3	2	84	1	0	0	0	0	1	0	0	0	16046	1145	40	3	1810	3	TM9SF4	20	30749133	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	382357	30749133	32276387	362	16930											
NCOA3	8202	broad.mit.edu	37	chr20	46281792	46281792	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaaccccatgcccatgtcTggcatgcctatgggtcctga	8	10	10	13	0	1	2	0	2	1	0	2	2	2	2	5	2	3	1	5	2	2	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr20:46281792T>C	uc002xtk.2	+	22	4444	c.4239T>C	c.(4237-4239)TCT>TCC	p.S1413S	NCOA3_uc002xtl.2_Silent_p.S1409S|NCOA3_uc002xtm.2_Silent_p.S1408S|NCOA3_uc002xtn.2_Silent_p.S1412S|NCOA3_uc010zyc.1_Silent_p.S1208S	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1413	Met-rich.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TGCCCATGTCTGGCATGCCTA	0.463													44	49					0	0	0	0	C	46281792	C	C	46281792	2	2	84	1	0	0	0	0	0	0	0	1	10284	1567	55	5		5	NCOA3	20	46281792	Silent	SNP	T	TCGA-CN-6992-01A-11D-1912-08	15532659	46281792	16743728	363	16931											
SLC9A8	23315	broad.mit.edu	37	chr20	48491309	48491309	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccataacctctccccagtCacccagatcctcatgcagca	11	7	4	19	0	3	1	2	0	1	1	5	1	4	1	6	0	3	2	6	0	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr20:48491309C>A	uc002xuv.1	+	11	1236	c.1026C>A	c.(1024-1026)GTC>GTA	p.V342V	SLC9A8_uc010zym.1_Silent_p.V42V|SLC9A8_uc010gic.2_Silent_p.V42V|SLC9A8_uc010gid.2_Intron	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	342						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TCTCCCCAGTCACCCAGATCC	0.557													34	81					1.30015e-28	2.36627e-28	1	0	A	48491309	A	A	48491309	2	1	84	1	0	0	0	0	0	0	0	1	14784	813	29	2		2	SLC9A8	20	48491309	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2209517	48491309	14534211	364	16932											
SLC9A8	23315	broad.mit.edu	37	chr20	48494548	48494548	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtttgcatttcttggcctgtCcatttttagttttcctcaca	5	20	6	10	0	2	0	1	0	1	0	4	0	4	0	3	1	1	3	3	1	1	8			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr20:48494548C>T	uc002xuv.1	+	12	1316	c.1106C>T	c.(1105-1107)TCC>TTC	p.S369F	SLC9A8_uc010zym.1_Missense_Mutation_p.S69F|SLC9A8_uc010gic.2_Missense_Mutation_p.S69F|SLC9A8_uc010gid.2_Intron	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	369	Helical; (Potential).					Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			CTTGGCCTGTCCATTTTTAGT	0.294													23	63					0	0	0	0	T	48494548	T	T	48494548	3	4	84	1	0	0	0	0	1	0	0	0	14784	855	30	2	1152	2	SLC9A8	20	48494548	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3239	48494548	14530972	365	16933											
GMEB2	26205	broad.mit.edu	37	chr20	62234382	62234382	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgaggttggctctgctgTctccacaggtgatggggtac	7	11	15	8	0	2	3	0	2	2	1	3	3	2	3	1	5	2	4	1	5	1	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr20:62234382T>C	uc002yfp.1	-	3	772	c.293A>G	c.(292-294)GAC>GGC	p.D98G	GMEB2_uc002yfo.1_Missense_Mutation_p.D20G|GMEB2_uc002yfq.1_Missense_Mutation_p.D98G	NM_012384	NP_036516	Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding	98	SAND.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding				0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			GGCTCTGCTGTCTCCACAGGT	0.532													23	88					0	0	0	0	C	62234382	C	C	62234382	3	2	84	1	0	0	0	0	1	0	0	0	6525	1667	58	5	1327	5	GMEB2	20	62234382	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	13739834	62234382	791138	366	16934											
ADAMTS1	9510	broad.mit.edu	37	chr21	28212319	28212319	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcgtgtactggactcctccaCcgcacgttctcgaacagtct	7	11	8	15	4	2	0	0	0	2	0	6	2	4	1	3	1	2	3	3	1	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr21:28212319C>A	uc002ymf.2	-	6	2182	c.1727G>T	c.(1726-1728)GGT>GTT	p.G576V		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	576	TSP type-1 1.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		GACTCCTCCACCGCACGTTCT	0.493													20	76					8.00594e-06	1.15641e-05	1	0	A	28212319	A	A	28212319	3	1	84	1	0	0	0	0	1	0	0	0	255	507	18	4	1192	4	ADAMTS1	21	28212319	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08		28212319	19917576	367	16935											
TIAM1	7074	broad.mit.edu	37	chr21	32624279	32624279	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctcctccaggctctcgctgTtggtggtgctcatctccagc	3	12	10	16	1	3	0	1	0	2	0	7	0	5	0	4	3	2	4	4	3	0	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr21:32624279T>C	uc002yow.1	-	6	1662	c.1190A>G	c.(1189-1191)AAC>AGC	p.N397S	TIAM1_uc011adk.1_Missense_Mutation_p.N397S|TIAM1_uc011adl.1_Missense_Mutation_p.N397S|TIAM1_uc002yox.1_Missense_Mutation_p.N5S	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	397					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GCTCTCGCTGTTGGTGGTGCT	0.687													18	29					0	0	0	0	C	32624279	C	C	32624279	3	2	84	1	0	0	0	0	1	0	0	0	15956	1725	60	5	3681	5	TIAM1	21	32624279	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	4411960	32624279	15505616	368	16936											
GART	2618	broad.mit.edu	37	chr21	34878305	34878305	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggaataccagctctttcCgctttatctaacccagctac	9	12	7	13	1	2	0	0	0	2	0	3	1	3	1	3	1	5	3	3	1	5	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr21:34878305C>T	uc002yrx.2	-	19	2694	c.2559G>A	c.(2557-2559)GCG>GCA	p.A853A	GART_uc002yrz.2_Silent_p.A853A|GART_uc010gmd.2_Silent_p.A515A|GART_uc002yry.2_Silent_p.A853A	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	853	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	CAGCTCTTTCCGCTTTATCTA	0.443													6	55					0	0	0	0	T	34878305	T	T	34878305	2	4	84	1	0	0	0	0	0	0	0	1	6278	639	23	1		1	GART	21	34878305	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	2254026	34878305	13251590	369	16937											
FBXO7	25793	broad.mit.edu	37	chr22	32894169	32894169	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atacaaagaaaagaatccccGaaagggcggtttgtgatgct	15	8	11	7	2	0	3	0	1	0	2	1	4	1	3	2	2	2	2	2	2	6	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr22:32894169G>A	uc003amq.2	+	9	1504	c.1221G>A	c.(1219-1221)CCG>CCA	p.P407P	FBXO7_uc003amr.2_Silent_p.P293P|FBXO7_uc003ams.2_Silent_p.P251P|FBXO7_uc003amt.2_Silent_p.P328P|FBXO7_uc003amu.2_Silent_p.P293P|FBXO7_uc003amv.2_Silent_p.P106P	NM_012179	NP_036311	Q9Y3I1	FBX7_HUMAN	F-box only protein 7 isoform 1	407					cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						AAGAATCCCCGAAAGGGCGGT	0.458													30	112					0	0	0	0	A	32894169	A	A	32894169	2	1	84	1	0	0	0	0	0	0	0	1	5792	1045	37	1		1	FBXO7	22	32894169	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08		32894169	18410397	370	16938											
NPTXR	23467	broad.mit.edu	37	chr22	39224292	39224292	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaggacccaggacccacCgtgctccagctcagccacac	9	4	9	19	1	1	0	1	0	0	0	2	2	2	2	5	2	4	3	5	2	0	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr22:39224292C>G	uc003awk.2	-	2	1004	c.850G>C	c.(850-852)GGG>CGG	p.G284R		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	284	Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					CAGGACCCACCGTGCTCCAGC	0.602													15	37					0	0	0	0	G	39224292	G	G	39224292	3	3	84	1	0	0	0	0	1	0	0	0	10658	666	23	3	668	3	NPTXR	22	39224292	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	6330123	39224292	12080274	371	16939											
KLHDC7B	113730	broad.mit.edu	37	chr22	50987660	50987660	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctctgcaccatgcacaactaCctgtttctggcggggggcat	7	10	11	13	1	2	0	0	0	2	0	2	0	2	0	2	4	4	4	2	4	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chr22:50987660C>T	uc003bmi.2	+	1	1199	c.1065C>T	c.(1063-1065)TAC>TAT	p.Y355Y		NM_138433	NP_612442	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	355	Kelch 2.									central_nervous_system(1)	1		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGCACAACTACCTGTTTCTGG	0.647													31	83					0	0	0	0	T	50987660	T	T	50987660	2	4	84	1	0	0	0	0	0	0	0	1	8400	518	18	4		4	KLHDC7B	22	50987660	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	11763368	50987660	316906	372	16940											
PPEF1	5475	broad.mit.edu	37	chrX	18836239	18836239	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaccttactcgtgctttcCaacttcaagaccacagaaaa	13	10	6	12	1	1	3	1	1	0	2	3	3	2	3	3	0	3	1	3	0	5	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:18836239C>A	uc004cyq.2	+	16	1958	c.1477C>A	c.(1477-1479)CAA>AAA	p.Q493K	PPEF1_uc004cyp.2_Missense_Mutation_p.Q465K|PPEF1_uc004cyr.2_Missense_Mutation_p.Q431K|PPEF1_uc004cys.2_Missense_Mutation_p.Q493K|PPEF1_uc011mja.1_Missense_Mutation_p.Q428K|PPEF1_uc011mjb.1_Missense_Mutation_p.Q437K	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	493	EF-hand 1.				detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					TCGTGCTTTCCAACTTCAAGA	0.353													31	15					5.60225e-13	9.0117e-13	1	0	A	18836239	A	A	18836239	3	1	84	1	0	0	0	0	1	0	0	0	12362	595	21	4	1527	4	PPEF1	23	18836239	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08		18836239	136434321	373	16941											
FTHL17	53940	broad.mit.edu	37	chrX	31089993	31089993	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taggaggtgtagagctccagCgtgatgtggctgttgatggc	7	11	17	6	1	0	3	0	2	0	1	1	4	1	4	1	4	2	4	1	4	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:31089993C>G	uc004dcl.1	-	1	181	c.78G>C	c.(76-78)ACG>ACC	p.T26T		NM_031894	NP_114100	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	26	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity				0						AGAGCTCCAGCGTGATGTGGC	0.627													23	18					0	0	0	0	G	31089993	G	G	31089993	2	3	84	1	0	0	0	0	0	0	0	1	6117	755	27	3		3	FTHL17	23	31089993	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	12253754	31089993	124180567	374	16942											
DMD	1756	broad.mit.edu	37	chrX	32536238	32536238	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgtgaagttcagttatatCaacatccaacctaagacagc	14	10	7	10	0	2	2	2	1	0	1	3	2	3	2	2	0	3	3	2	0	6	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:32536238C>G	uc004dda.1	-	18	2423	c.2179G>C	c.(2179-2181)GAT>CAT	p.D727H	DMD_uc004dcz.2_Missense_Mutation_p.D604H|DMD_uc004dcy.1_Missense_Mutation_p.D723H|DMD_uc004ddb.1_Missense_Mutation_p.D719H|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.D719H	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	727	Spectrin 4.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCAGTTATATCAACATCCAAC	0.333													11	5					0	0	0	0	G	32536238	G	G	32536238	3	3	84	1	0	0	0	0	1	0	0	0	4602	826	29	2	9369	2	DMD	23	32536238	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1446245	32536238	122734322	375	16943											
KCND1	3750	broad.mit.edu	37	chrX	48822582	48822582	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgcttggccctgcgagggCagcaagaagacagcaggctt	9	5	16	11	2	0	2	0	0	0	2	0	3	0	2	1	4	3	5	1	4	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:48822582C>A	uc004dlx.1	-	5	3171	c.1598G>T	c.(1597-1599)TGC>TTC	p.C533F	KCND1_uc004dlw.1_Missense_Mutation_p.C156F	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	533	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						CCTGCGAGGGCAGCAAGAAGA	0.682													24	9					4.72057e-08	6.97681e-08	1	0	A	48822582	A	A	48822582	3	1	84	1	0	0	0	0	1	0	0	0	8057	710	25	4	353	4	KCND1	23	48822582	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	16286344	48822582	106447978	376	16944											
CCNB3	85417	broad.mit.edu	37	chrX	50052941	50052941	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcgttgtctttacaggaaaAgaaaattactcaggggaaga	16	10	10	5	1	2	2	1	0	1	2	3	4	2	4	0	3	2	1	0	3	7	4			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:50052941A>T	uc004dox.3	+	6	2070	c.1772A>T	c.(1771-1773)AAG>ATG	p.K591M	CCNB3_uc004doy.2_Missense_Mutation_p.K591M|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	591					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding	p.K591T(2)		ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TTACAGGAAAAGAAAATTACT	0.408													13	9					0	0	0	0	T	50052941	T	T	50052941	3	4	84	1	0	0	0	0	1	0	0	0	2929	72	3	5	1786	5	CCNB3	23	50052941	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	1230359	50052941	105217619	377	16945											
KLHL4	56062	broad.mit.edu	37	chrX	86877360	86877360	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtggggcatgatgtgcaGaataggcaaggagaactggg	11	7	19	4	0	0	3	0	1	0	2	0	4	0	3	0	6	2	3	0	6	4	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:86877360G>T	uc004efb.2	+	5	1256	c.1074G>T	c.(1072-1074)CAG>CAT	p.Q358H	KLHL4_uc004efa.2_Missense_Mutation_p.Q358H	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	358						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						ATGATGTGCAGAATAGGCAAG	0.408													42	14					7.05377e-20	1.23781e-19	1	0	T	86877360	T	T	86877360	3	4	84	1	0	0	0	0	1	0	0	0	8430	933	33	2	1092	2	KLHL4	23	86877360	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	36824419	86877360	68393200	378	16946											
GPRASP2	114928	broad.mit.edu	37	chrX	101969964	101969964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccaaaactgagaccaagtCtgtgcctgcggcaaggccca	11	5	11	14	1	1	1	0	1	1	1	1	2	1	1	4	2	3	1	4	2	4	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:101969964C>T	uc004ejk.2	+	4	1501	c.167C>T	c.(166-168)TCT>TTT	p.S56F	GPRASP2_uc004ejl.2_Missense_Mutation_p.S56F|GPRASP2_uc004ejm.2_Missense_Mutation_p.S56F|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	56						cytoplasm	protein binding			ovary(1)	1						GAGACCAAGTCTGTGCCTGCG	0.567													55	16					0	0	0	0	T	101969964	T	T	101969964	3	4	84	1	0	0	0	0	1	0	0	0	6762	913	32	2	169	2	GPRASP2	23	101969964	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	15092604	101969964	53300596	379	16947											
GLRA4	441509	broad.mit.edu	37	chrX	102979899	102979899	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgtctaggaaatcagagggGgacatgggctgggacccctt	9	9	15	8	0	2	1	1	0	1	1	2	4	2	4	2	5	0	1	2	5	2	3			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:102979899G>T	uc011mse.1	-	2	550	c.129C>A	c.(127-129)TCC>TCA	p.S43S	GLRA4_uc010nou.2_Silent_p.S43S	NM_001024452	NP_001019623	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4 precursor	43	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity				0						AATCAGAGGGGGACATGGGCT	0.468													7	3					0.00307968	0.00423705	1	0	T	102979899	T	T	102979899	2	4	84	1	0	0	0	0	0	0	0	1	6494	1219	43	4		4	GLRA4	23	102979899	Silent	SNP	G	TCGA-CN-6992-01A-11D-1912-08	1009935	102979899	52290661	380	16948											
COL4A5	1287	broad.mit.edu	37	chrX	107844632	107844632	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttgctttcaggtcctaaagGggatccaggtcagactataa	11	11	10	9	0	2	1	2	0	0	1	4	2	4	2	2	4	1	1	2	4	4	5			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:107844632G>T	uc004enz.1	+	26	2160	c.1958G>T	c.(1957-1959)GGG>GTG	p.G653V	COL4A5_uc011mso.1_Missense_Mutation_p.G653V|COL4A5_uc004eob.1_Missense_Mutation_p.G261V	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	653	Triple-helical region.		G -> R (in APSX; juvenile type).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GGTCCTAAAGGGGATCCAGGT	0.408									Alport_syndrome_with_Diffuse_Leiomyomatosis				11	2					6.40141e-05	9.08173e-05	1	0	T	107844632	T	T	107844632	3	4	84	1	0	0	0	0	1	0	0	0	3709	1232	43	4	2060	4	COL4A5	23	107844632	Missense_Mutation	SNP	G	TCGA-CN-6992-01A-11D-1912-08	4864733	107844632	47425928	381	16949											
RGAG1	57529	broad.mit.edu	37	chrX	109695339	109695339	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcctctggaaagatgtcCacgccactgaggagagctcc	11	6	11	13	1	1	3	0	1	1	2	3	5	3	4	4	2	2	1	4	2	1	0			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:109695339C>T	uc004eor.1	+	3	1740	c.1494C>T	c.(1492-1494)TCC>TCT	p.S498S	RGAG1_uc011msr.1_Silent_p.S498S	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	498										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GAAAGATGTCCACGCCACTGA	0.507													96	33					0	0	0	0	T	109695339	T	T	109695339	2	4	84	1	0	0	0	0	0	0	0	1	13339	581	21	4		4	RGAG1	23	109695339	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1850707	109695339	45575221	382	16950											
DOCK11	139818	broad.mit.edu	37	chrX	117700005	117700005	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgcttttgaactcaagaTgttagataaatatagccatt	14	15	6	6	0	2	3	2	1	0	2	2	3	2	3	1	0	3	2	1	0	7	7			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:117700005T>C	uc004eqp.2	+	8	794	c.731T>C	c.(730-732)ATG>ACG	p.M244T	DOCK11_uc004eqq.2_Missense_Mutation_p.M10T	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	244	PH.				blood coagulation	cytosol	GTP binding			ovary(3)	3						GAACTCAAGATGTTAGATAAA	0.373													88	20					0	0	0	0	C	117700005	C	C	117700005	3	2	84	1	0	0	0	0	1	0	0	0	4708	1464	51	5	761	5	DOCK11	23	117700005	Missense_Mutation	SNP	T	TCGA-CN-6992-01A-11D-1912-08	8004666	117700005	37570555	383	16951											
RHOXF2B	727940	broad.mit.edu	37	chrX	119211023	119211023	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctctggtcgctgtcctcaaCgttgccatcgctgccgctgg	3	11	12	15	4	2	0	1	0	1	0	5	0	3	0	3	2	3	5	3	2	1	1			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:119211023C>T	uc004esj.3	-	2	500	c.310G>A	c.(310-312)GTT>ATT	p.V104I	uc004esi.1_Intron	NM_032498	NP_115887	P0C7M4	RHF2B_HUMAN	Rhox homeobox family, member 2	104						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTGTCCTCAACGTTGCCATCG	0.652													11	36					0	0	0	0	T	119211023	T	T	119211023	3	4	84	1	0	0	0	0	1	0	0	0	13414	536	19	1	568	1	RHOXF2B	23	119211023	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	1511018	119211023	36059537	384	16952											
THOC2	57187	broad.mit.edu	37	chrX	122755304	122755304	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttttcatctttatttggcCgctcttcctttggtttttct	2	24	5	10	1	4	0	1	0	3	0	5	0	5	0	2	2	0	2	2	2	1	9			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:122755304C>T	uc004etu.2	-	31	3952	c.3920G>A	c.(3919-3921)CGG>CAG	p.R1307Q	THOC2_uc010nqt.1_RNA|THOC2_uc004etw.1_Missense_Mutation_p.R128Q	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1307	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TTTATTTGGCCGCTCTTCCTT	0.343													7	91					0	0	0	0	T	122755304	T	T	122755304	3	4	84	1	0	0	0	0	1	0	0	0	15931	652	23	1	893	1	THOC2	23	122755304	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	3544281	122755304	32515256	385	16953											
RBMX2	51634	broad.mit.edu	37	chrX	129546423	129546423	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcctcttcgtcacccagAcgcaagacagtaaaggaaaa	15	6	7	13	2	2	2	1	0	1	2	4	3	3	3	3	1	0	2	3	1	5	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:129546423A>T	uc004evt.2	+	6	634	c.570A>T	c.(568-570)AGA>AGT	p.R190S		NM_016024	NP_057108	Q9Y388	RBMX2_HUMAN	RNA binding motif protein, X-linked 2	190	Lys-rich.						nucleotide binding|RNA binding			breast(3)|ovary(1)	4						CGTCACCCAGACGCAAGACAG	0.448													33	5					0	0	0	0	T	129546423	T	T	129546423	3	4	84	1	0	0	0	0	1	0	0	0	13217	272	10	5	592	5	RBMX2	23	129546423	Missense_Mutation	SNP	A	TCGA-CN-6992-01A-11D-1912-08	6791119	129546423	25724137	386	16954											
GPR112	139378	broad.mit.edu	37	chrX	135429438	135429438	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcagcttcccatatactttCagtggtggtggagttgttgc	6	15	11	9	0	2	0	2	0	0	0	3	1	3	1	1	3	3	3	1	3	2	6			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:135429438C>T	uc004ezu.1	+	6	3864	c.3573C>T	c.(3571-3573)TTC>TTT	p.F1191F	GPR112_uc010nsb.1_Silent_p.F986F|GPR112_uc010nsc.1_Silent_p.F958F	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1191	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CATATACTTTCAGTGGTGGTG	0.473													72	25					0	0	0	0	T	135429438	T	T	135429438	2	4	84	1	0	0	0	0	0	0	0	1	6667	825	29	2		2	GPR112	23	135429438	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	5883015	135429438	19841122	387	16955											
MAGEC2	51438	broad.mit.edu	37	chrX	141290919	141290919	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgtggggcacctcccgataCtccaggtaatgtccctgcac	7	9	10	15	1	0	0	0	0	0	0	3	1	3	0	4	3	2	3	4	3	2	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:141290919C>G	uc004fbu.1	-	3	1203	c.855G>C	c.(853-855)GAG>GAC	p.E285D		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	285	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCCGATACTCCAGGTAAT	0.502										HNSCC(46;0.14)			63	16					0	0	0	0	G	141290919	G	G	141290919	3	3	84	1	0	0	0	0	1	0	0	0	9234	564	20	4	270	4	MAGEC2	23	141290919	Missense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	5861481	141290919	13979641	388	16956											
AFF2	2334	broad.mit.edu	37	chrX	147743456	147743456	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtgatgcacttgccaacCgagtccagaacacgcttgga	12	7	11	11	2	0	2	0	1	0	1	1	4	1	3	3	2	4	2	3	2	3	2			TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:147743456C>T	uc004fcp.2	+	3	687	c.208C>T	c.(208-210)CGA>TGA	p.R70*	AFF2_uc004fco.2_Nonsense_Mutation_p.R66*|AFF2_uc004fcq.2_Nonsense_Mutation_p.R66*|AFF2_uc004fcr.2_Nonsense_Mutation_p.R66*|AFF2_uc011mxb.1_Nonsense_Mutation_p.R70*|AFF2_uc004fcs.2_Nonsense_Mutation_p.R66*	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	70					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ACTTGCCAACCGAGTCCAGAA	0.388													67	30					0	0	0	0	T	147743456	T	T	147743456	4	4	84	1	0	0	0	0	0	1	0	0	357	644	23	1	218	1	AFF2	23	147743456	Nonsense_Mutation	SNP	C	TCGA-CN-6992-01A-11D-1912-08	6452537	147743456	7527104	389	16957											
FUNDC2	65991	broad.mit.edu	37	chrX	154261754	154261754	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatggtggcgtaagctgttCgggcaggaatctggaccttc	7	10	14	10	2	1	0	0	0	1	0	3	2	1	2	2	5	1	4	2	5	2	3	rs147164809		TCGA-CN-6992-01A-11D-1912-08	TCGA-CN-6992-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	7a70356c-74a3-40c3-bd32-3049da642831	a6505059-a7f7-44bb-9d7b-9554b28effc9	g.chrX:154261754C>T	uc004fmw.2	+	2	360	c.210C>T	c.(208-210)TTC>TTT	p.F70F		NM_023934	NP_076423	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	70						mitochondrion					0	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GTAAGCTGTTCGGGCAGGAAT	0.458													9	55					0	0	0	0	T	154261754	T	T	154261754	2	4	84	1	0	0	0	0	0	0	0	1	6132	883	31	1		1	FUNDC2	23	154261754	Silent	SNP	C	TCGA-CN-6992-01A-11D-1912-08	6518298	154261754	1008806	390	16958											
EPS15	2060	broad.mit.edu	37	chr1	51873905	51873905	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccaattctgctgtttcttGctgtagacggctcagctctt	5	16	8	12	1	4	1	1	0	3	1	5	1	5	1	1	1	3	6	1	1	2	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr1:51873905G>C	uc001csq.1	-	15	1467	c.1375C>G	c.(1375-1377)CAA>GAA	p.Q459E	EPS15_uc009vyz.1_Intron|EPS15_uc001csp.3_Missense_Mutation_p.Q145E	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	459					cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						GCTGTTTCTTGCTGTAGACGG	0.448			T	MLL	ALL								24	81					0	0	0	0	C	51873905	C	C	51873905	3	2	85	1	0	0	0	0	1	0	0	0	5216	1328	46	4	1359	4	EPS15	1	51873905	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08		51873905	197376716	1	16959											
CDCP2	200008	broad.mit.edu	37	chr1	54607036	54607036	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtggcactccatgctgttCgggtagttgttgggatactc	6	13	13	9	1	0	0	0	0	0	0	3	1	1	1	1	3	2	6	1	3	2	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr1:54607036C>T	uc001cwv.1	-	3	1346	c.498G>A	c.(496-498)CCG>CCA	p.P166P		NM_201546	NP_963840	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2 precursor	166	CUB 2.					extracellular region				ovary(1)	1						CCATGCTGTTCGGGTAGTTGT	0.607													22	20					0	0	0	0	T	54607036	T	T	54607036	2	4	85	1	0	0	0	0	0	0	0	1	3109	871	31	1		1	CDCP2	1	54607036	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08	2733131	54607036	194643585	2	16960											
FLG	2312	broad.mit.edu	37	chr1	152281946	152281946	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtcctgaccctcttgggAcgctgagtgcctggagctgt	4	11	15	11	1	1	2	0	2	1	0	2	4	2	4	3	3	2	2	3	3	0	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr1:152281946A>C	uc001ezu.1	-	3	5452	c.5416T>G	c.(5416-5418)TCC>GCC	p.S1806A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1806	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTCTTGGGACGCTGAGTGC	0.592									Ichthyosis				96	393					0	0	0	0	C	152281946	C	C	152281946	3	2	85	1	0	0	0	0	1	0	0	0	5954	275	10	5	6773	5	FLG	1	152281946	Missense_Mutation	SNP	A	TCGA-CN-6994-01A-11D-1912-08	97674910	152281946	96968675	3	16961											
SERPINC1	462	broad.mit.edu	37	chr1	173883822	173883822	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccaggtgctgatagaaagTggtagcaaagcgggaattgg	12	8	16	5	1	0	2	0	1	0	1	0	3	0	3	1	4	4	3	1	4	5	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr1:173883822T>G	uc001gjt.2	-	2	396	c.277A>C	c.(277-279)ACT>CCT	p.T93P		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	93					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	TGATAGAAAGTGGTAGCAAAG	0.522											OREG0013990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	85					0	0	0	0	G	173883822	G	G	173883822	3	3	85	1	0	0	0	0	1	0	0	0	14174	1696	59	5	1141	5	SERPINC1	1	173883822	Missense_Mutation	SNP	T	TCGA-CN-6994-01A-11D-1912-08	21601876	173883822	75366799	4	16962											
FMN2	56776	broad.mit.edu	37	chr1	240256799	240256799	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccctggcctccgtagccGccccggccaagaagcaccgg	6	4	12	19	4	0	1	0	0	0	1	1	1	1	1	8	3	3	2	8	3	3	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr1:240256799G>A	uc010pyd.1	+	1	1615	c.1390G>A	c.(1390-1392)GCC>ACC	p.A464T	FMN2_uc010pye.1_Missense_Mutation_p.A464T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	464					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTCCGTAGCCGCCCCGGCCAA	0.726													7	29					0	0	0	0	A	240256799	A	A	240256799	3	1	85	1	0	0	0	0	1	0	0	0	5982	1087	38	1	1392	1	FMN2	1	240256799	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	66372977	240256799	8993822	5	16963											
TPO	7173	broad.mit.edu	37	chr2	1481015	1481015	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgacctcgttcctggacgCgtccaccgtgtatggcagct	5	11	12	13	4	0	1	0	1	0	0	3	2	2	2	4	2	1	5	4	2	1	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:1481015C>T	uc002qww.2	+	8	1068	c.977C>T	c.(976-978)GCG>GTG	p.A326V	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.A326V|TPO_uc002qwr.2_Missense_Mutation_p.A326V|TPO_uc002qwx.2_Missense_Mutation_p.A326V|TPO_uc010yio.1_Intron|TPO_uc010yip.1_Missense_Mutation_p.A326V	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	326	Extracellular (Potential).		A -> T (in TDH2A).		cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TTCCTGGACGCGTCCACCGTG	0.701													7	14					0	0	0	0	T	1481015	T	T	1481015	3	4	85	1	0	0	0	0	1	0	0	0	16477	768	27	1	1003	1	TPO	2	1481015	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08		1481015	241718358	6	16964											
CEBPZ	10153	broad.mit.edu	37	chr2	37449559	37449559	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcacccaggaagcaacctCtggttttttggtttctacat	8	14	9	10	0	2	0	0	0	2	0	2	1	2	1	2	3	4	4	2	3	3	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:37449559C>G	uc002rpz.2	-	4	2059	c.2029G>C	c.(2029-2031)GAG>CAG	p.E677Q		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	677					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				GAAGCAACCTCTGGTTTTTTG	0.353													11	74					0	0	0	0	G	37449559	G	G	37449559	3	3	85	1	0	0	0	0	1	0	0	0	3219	922	32	2	1187	2	CEBPZ	2	37449559	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	35968544	37449559	205749814	7	16965											
NCAPH	23397	broad.mit.edu	37	chr2	97024809	97024809	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aatgatttcccttggggatgGagacatcaggaccatgtgcc	10	10	12	9	0	1	2	1	1	0	1	2	5	2	4	3	4	1	0	3	4	1	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:97024809G>T	uc002svz.1	+	10	1319	c.1235G>T	c.(1234-1236)GGA>GTA	p.G412V	NCAPH_uc010fhu.1_Missense_Mutation_p.G388V|NCAPH_uc010fhv.1_Missense_Mutation_p.G401V|NCAPH_uc010yum.1_Missense_Mutation_p.G388V|NCAPH_uc010fhw.1_Missense_Mutation_p.G401V|NCAPH_uc010yun.1_Missense_Mutation_p.G276V|NCAPH_uc002swa.1_Missense_Mutation_p.G7V	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	412					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				CTTGGGGATGGAGACATCAGG	0.433													12	76					5.50884e-06	7.02377e-06	1	0	T	97024809	T	T	97024809	3	4	85	1	0	0	0	0	1	0	0	0	10263	1174	41	2	1273	2	NCAPH	2	97024809	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	59575250	97024809	146174564	8	16966											
IL18R1	8809	broad.mit.edu	37	chr2	103006518	103006518	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccctttcttttctagcaGacatggctgatatcccaggc	7	15	7	12	0	2	2	0	1	2	1	4	2	4	2	2	2	1	2	2	2	2	6			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:103006518G>T	uc002tbw.3	+	9	1102	c.952G>T	c.(952-954)GAC>TAC	p.D318Y	IL18R1_uc010ywc.1_Splice_Site_p.D317_splice|IL18R1_uc010ywd.1_Splice_Site_p.D162_splice|IL18R1_uc010fiy.2_Missense_Mutation_p.D318Y	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	318	Extracellular (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						TTTTCTAGCAGACATGGCTGA	0.403													19	26					2.35188e-11	3.15647e-11	1	0	T	103006518	T	T	103006518	3	4	85	1	0	0	0	0	1	0	0	0	7686	942	33	2	982	2	IL18R1	2	103006518	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	5981709	103006518	140192855	9	16967											
MERTK	10461	broad.mit.edu	37	chr2	112705062	112705062	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggctgtgggcccgcctgaGcccgtcaacattttctgggt	5	10	13	13	2	2	1	1	1	1	0	2	1	2	1	3	3	2	1	3	3	1	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:112705062G>C	uc002thk.1	+	4	797	c.675G>C	c.(673-675)GAG>GAC	p.E225D	MERTK_uc002thl.1_Missense_Mutation_p.E49D	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	225	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GCCCGCCTGAGCCCGTCAACA	0.532													37	61					0	0	0	0	C	112705062	C	C	112705062	3	2	85	1	0	0	0	0	1	0	0	0	9532	962	34	4	689	4	MERTK	2	112705062	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	9698544	112705062	130494311	10	16968											
LRP1B	53353	broad.mit.edu	37	chr2	141528566	141528566	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caccattgtttagttggcagGaattgctgcctgcatagaat	10	13	10	8	0	0	1	0	0	0	1	0	2	0	2	2	2	3	5	2	2	4	6			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:141528566G>A	uc002tvj.1	-	34	6482	c.5510C>T	c.(5509-5511)TCC>TTC	p.S1837F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1837	Extracellular (Potential).|EGF-like 4.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAGTTGGCAGGAATTGCTGCC	0.299										TSP Lung(27;0.18)			10	23					0	0	0	0	A	141528566	A	A	141528566	3	1	85	1	0	0	0	0	1	0	0	0	9005	1174	41	2	8521	2	LRP1B	2	141528566	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	28823504	141528566	101670807	11	16969											
BAZ2B	29994	broad.mit.edu	37	chr2	160240133	160240133	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacttgcggagtttaccttCtaccacccatttatctctcc	7	16	4	14	1	2	0	0	0	2	0	4	1	3	1	4	1	4	1	4	1	4	8			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:160240133C>G	uc002uao.2	-	24	4097	c.3745G>C	c.(3745-3747)GAA>CAA	p.E1249Q	BAZ2B_uc002uap.2_Missense_Mutation_p.E1213Q	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AGTTTACCTTCTACCACCCAT	0.303													6	26					0	0	0	0	G	160240133	G	G	160240133	3	3	85	1	0	0	0	0	1	0	0	0	1334	922	32	2	2817	2	BAZ2B	2	160240133	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	18711567	160240133	82959240	12	16970											
SLC4A10	57282	broad.mit.edu	37	chr2	162728868	162728868	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataaaaatgatgttagcagaGaaaacagcactgttgacttt	17	11	8	5	0	0	3	0	2	0	1	0	4	0	3	0	0	3	4	0	0	6	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:162728868G>A	uc002ubx.3	+	7	1016	c.832G>A	c.(832-834)GAA>AAA	p.E278K	SLC4A10_uc010fpa.1_Missense_Mutation_p.E290K|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.E278K|SLC4A10_uc010zcs.1_Missense_Mutation_p.E289K	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	278	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TGTTAGCAGAGAAAACAGCAC	0.373											OREG0004894	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	16	85					0	0	0	0	A	162728868	A	A	162728868	3	1	85	1	0	0	0	0	1	0	0	0	14715	943	33	2	943	2	SLC4A10	2	162728868	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	2488735	162728868	80470505	13	16971											
ANKRD44	91526	broad.mit.edu	37	chr2	197990126	197990126	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtatgctgcccagtgcaGagcacgccggtccttcttgt	6	11	11	13	2	1	1	0	0	1	1	2	1	2	1	3	1	4	4	3	1	1	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:197990126G>T	uc002uuc.2	-	6	696	c.529C>A	c.(529-531)CTG>ATG	p.L177M	ANKRD44_uc002utz.3_5'Flank|ANKRD44_uc002uua.1_Missense_Mutation_p.L152M|ANKRD44_uc002uub.2_Missense_Mutation_p.L177M|ANKRD44_uc010zgw.1_Missense_Mutation_p.L105M	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	177	ANK 6.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GCCCAGTGCAGAGCACGCCGG	0.428													31	91					7.11191e-15	9.86959e-15	1	0	T	197990126	T	T	197990126	3	4	85	1	0	0	0	0	1	0	0	0	672	933	33	2	2389	2	ANKRD44	2	197990126	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	35261258	197990126	45209247	14	16972			1	21		6	5	627	N	G	2.570288e-12
ANKRD44	91526	broad.mit.edu	37	chr2	197990157	197990157	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccttcttgtcaaatgcattGatatttgcccctttggccaa	8	16	6	11	0	2	1	1	1	1	0	3	1	3	1	4	1	2	1	4	1	3	6			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:197990157G>C	uc002uuc.2	-	6	665	c.498C>G	c.(496-498)ATC>ATG	p.I166M	ANKRD44_uc002utz.3_5'Flank|ANKRD44_uc002uua.1_Missense_Mutation_p.I141M|ANKRD44_uc002uub.2_Missense_Mutation_p.I166M|ANKRD44_uc010zgw.1_Missense_Mutation_p.I94M	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	166	ANK 5.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CAAATGCATTGATATTTGCCC	0.438													34	108					0	0	0	0	C	197990157	C	C	197990157	3	2	85	1	0	0	0	0	1	0	0	0	672	1280	45	2	2420	2	ANKRD44	2	197990157	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	31	197990157	45209216	15	16973			1	21		6	5	627	N	G	2.570288e-12
ANKRD44	91526	broad.mit.edu	37	chr2	197990618	197990618	+	Silent	SNP	G	A	A																															gtgcgcccccctcggtcggaGacattgacactgctcagcag																										TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:197990618G>A	uc002uuc.2	-	5	572	c.405C>T	c.(403-405)GTC>GTT	p.V135V	ANKRD44_uc002uua.1_Silent_p.V110V|ANKRD44_uc002uub.2_Silent_p.V135V|ANKRD44_uc010zgw.1_Silent_p.V63V	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	135	ANK 4.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTCGGTCGGAGACATTGACAC	0.557													29	125					0	0	0	0	A	197990618	A	A	197990618	2	1	85	1	0	0	0	0	0	0	0	1	672	929	33	2		2	ANKRD44	2	197990618	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	461	197990618	45208755	16	16974	34	2	1	21		6	5	627	N	G	2.570288e-12
ANKRD44	91526	broad.mit.edu	37	chr2	197990624	197990624	+	Silent	SNP	G	A	A																															ccccctcggtcggagacattGacactgctcagcaggggaat																										TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:197990624G>A	uc002uuc.2	-	5	566	c.399C>T	c.(397-399)GTC>GTT	p.V133V	ANKRD44_uc002uua.1_Silent_p.V108V|ANKRD44_uc002uub.2_Silent_p.V133V|ANKRD44_uc010zgw.1_Silent_p.V61V	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	133	ANK 4.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CGGAGACATTGACACTGCTCA	0.547													32	128					0	0	0	0	A	197990624	A	A	197990624	2	1	85	1	0	0	0	0	0	0	0	1	672	1277	45	2		2	ANKRD44	2	197990624	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	6	197990624	45208749	17	16975	34	2	1	21		6	5	627	N	G	2.570288e-12
ANKRD44	91526	broad.mit.edu	37	chr2	197990663	197990663	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgatcacttctgcacatttGacagccttgttggctgctgc	7	14	9	11	0	2	2	1	2	1	0	2	2	2	2	1	1	4	4	1	1	0	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:197990663G>A	uc002uuc.2	-	5	527	c.360C>T	c.(358-360)GTC>GTT	p.V120V	ANKRD44_uc002uua.1_Silent_p.V95V|ANKRD44_uc002uub.2_Silent_p.V120V|ANKRD44_uc010zgw.1_Silent_p.V48V	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	120	ANK 4.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTGCACATTTGACAGCCTTGT	0.552													41	138					0	0	0	0	A	197990663	A	A	197990663	2	1	85	1	0	0	0	0	0	0	0	1	672	1277	45	2		2	ANKRD44	2	197990663	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	39	197990663	45208710	18	16976			1	21		6	5	627	N	G	2.570288e-12
ANKRD44	91526	broad.mit.edu	37	chr2	197990752	197990752	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgagtgcttaatcaaaacctGtactgcttcctacaacaaaa	15	11	5	10	0	1	1	1	1	0	0	2	1	2	1	2	0	6	3	2	0	8	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:197990752G>A	uc002uuc.2	-	5	438	c.271C>T	c.(271-273)CAG>TAG	p.Q91*	ANKRD44_uc002uua.1_Nonsense_Mutation_p.Q66*|ANKRD44_uc002uub.2_Nonsense_Mutation_p.Q91*|ANKRD44_uc010zgw.1_Nonsense_Mutation_p.Q19*	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	91	ANK 3.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			ATCAAAACCTGTACTGCTTCC	0.463													27	94					0	0	0	0	A	197990752	A	A	197990752	4	1	85	1	0	0	0	0	0	1	0	0	672	1386	48	4	2651	4	ANKRD44	2	197990752	Nonsense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	89	197990752	45208621	19	16977			1	21		6	5	627	N	G	2.570288e-12
THAP4	51078	broad.mit.edu	37	chr2	242542453	242542453	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcgaatgaagccacactctCtgtgcatcggcttgcgcgtg	7	9	13	12	4	1	1	0	1	1	0	3	2	1	1	1	2	3	2	1	2	2	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr2:242542453C>G	uc002wbt.2	-	4	1665	c.1442G>C	c.(1441-1443)AGA>ACA	p.R481T	THAP4_uc002wbs.2_Missense_Mutation_p.R69T	NM_015963	NP_057047	Q8WY91	THAP4_HUMAN	THAP domain containing 4 isoform 1	481							DNA binding|metal ion binding				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		GCCACACTCTCTGTGCATCGG	0.632													20	47					0	0	0	0	G	242542453	G	G	242542453	3	3	85	1	0	0	0	0	1	0	0	0	15912	913	32	2	303	2	THAP4	2	242542453	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	44551701	242542453	656920	20	16978											
CRTAP	10491	broad.mit.edu	37	chr3	33174068	33174068	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaacgacctgaagaatgcagCcccctgtgcagtcagctatc	11	7	10	13	1	1	2	1	1	0	1	2	4	1	2	3	0	5	3	3	0	4	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr3:33174068C>A	uc003cfl.3	+	5	1064	c.944C>A	c.(943-945)GCC>GAC	p.A315D	CRTAP_uc010hfz.2_Missense_Mutation_p.A272D|CRTAP_uc003cfm.2_Missense_Mutation_p.A136D|CRTAP_uc003cfn.2_Missense_Mutation_p.A136D	NM_006371	NP_006362	O75718	CRTAP_HUMAN	cartilage associated protein precursor	315						proteinaceous extracellular matrix	binding				0						AAGAATGCAGCCCCCTGTGCA	0.473													57	31					7.47603e-22	1.07402e-21	1	0	A	33174068	A	A	33174068	3	1	85	1	0	0	0	0	1	0	0	0	3913	739	26	4	962	4	CRTAP	3	33174068	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08		33174068	164848362	21	16979											
NKTR	4820	broad.mit.edu	37	chr3	42660540	42660540	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggccttgggaaaacaactggGaagaagttatgttataaagg	15	9	13	4	0	0	1	0	0	0	1	0	3	0	3	1	4	2	2	1	4	9	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr3:42660540G>C	uc003clo.2	+	4	309	c.162G>C	c.(160-162)GGG>GGC	p.G54G	NKTR_uc003cll.1_Silent_p.G54G|NKTR_uc003clm.1_5'UTR|NKTR_uc003clp.2_5'UTR|NKTR_uc011azp.1_5'UTR|NKTR_uc003clq.1_5'Flank	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	54	PPIase cyclophilin-type.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		AAACAACTGGGAAGAAGTTAT	0.348													10	28					0	0	0	0	C	42660540	C	C	42660540	2	2	85	1	0	0	0	0	0	0	0	1	10502	1161	41	2		2	NKTR	3	42660540	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	9486472	42660540	155361890	22	16980											
PARP3	10039	broad.mit.edu	37	chr3	51979210	51979210	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgcccatcaattcccctgaGcttctgcaggccaagaagga	10	7	9	15	1	2	2	1	1	1	1	3	3	3	3	5	2	2	2	5	2	3	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr3:51979210G>T	uc003dby.2	+	6	1202	c.831G>T	c.(829-831)GAG>GAT	p.E277D	PARP3_uc003dbz.2_Missense_Mutation_p.E284D	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	277	PARP alpha-helical.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		ATTCCCCTGAGCTTCTGCAGG	0.627													29	14					9.39395e-14	1.28615e-13	1	0	T	51979210	T	T	51979210	3	4	85	1	0	0	0	0	1	0	0	0	11516	962	34	4	874	4	PARP3	3	51979210	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	9318670	51979210	146043220	23	16981											
PROS1	5627	broad.mit.edu	37	chr3	93603601	93603601	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgaaattgagcaattccaGaaccaggatagtaggagccc	14	8	11	8	0	0	3	0	2	0	1	1	5	1	5	3	2	3	2	3	2	5	4	rs5017714		TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr3:93603601G>C	uc003drb.3	-	12	1804	c.1463C>G	c.(1462-1464)TCT>TGT	p.S488C	PROS1_uc010hoo.2_Missense_Mutation_p.S357C|PROS1_uc003dqz.3_Missense_Mutation_p.S357C	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	488	Laminin G-like 2.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	AGCAATTCCAGAACCAGGATA	0.313													7	40					0	0	0	0	C	93603601	C	C	93603601	3	2	85	1	0	0	0	0	1	0	0	0	12620	942	33	2	583	2	PROS1	3	93603601	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	41624391	93603601	104418829	24	16982											
C3orf17	25871	broad.mit.edu	37	chr3	112724658	112724658	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtatctgtagcactcttccGagtcccttgagagaactgct	8	12	10	11	1	2	2	0	1	2	1	4	4	4	2	2	1	3	4	2	1	3	4	rs143719239	byFrequency	TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr3:112724658G>A	uc003dzr.2	-	9	1490	c.1429C>T	c.(1429-1431)CGG>TGG	p.R477W	GTPBP8_uc011bhy.1_Intron|C3orf17_uc003dzq.2_Missense_Mutation_p.R102W|C3orf17_uc011bhz.1_Missense_Mutation_p.R102W|C3orf17_uc010hqh.2_Missense_Mutation_p.R102W|C3orf17_uc003dzt.2_Missense_Mutation_p.R380W|C3orf17_uc003dzs.2_Missense_Mutation_p.R341W|C3orf17_uc010hqg.2_Missense_Mutation_p.R302W|C3orf17_uc011bia.1_Missense_Mutation_p.R274W|C3orf17_uc003dzu.2_Missense_Mutation_p.R406W|C3orf17_uc011bib.1_Missense_Mutation_p.R366W|C3orf17_uc011bic.1_Missense_Mutation_p.R310W|C3orf17_uc011bid.1_RNA	NM_015412	NP_056227	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871	477						integral to membrane					0						GCACTCTTCCGAGTCCCTTGA	0.433													8	62					0	0	0	0	A	112724658	A	A	112724658	3	1	85	1	0	0	0	0	1	0	0	0	2220	1057	37	1	278	1	C3orf17	3	112724658	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	19121057	112724658	85297772	25	16983											
TMEM22	80723	broad.mit.edu	37	chr3	136573476	136573476	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatccaaagaaaggtctgctGagtgaaatgaaaaaaaaagg	21	6	10	4	0	1	4	0	3	1	1	2	4	2	4	1	2	1	1	1	2	8	0			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr3:136573476G>C	uc003erf.3	+	2	388	c.174G>C	c.(172-174)CTG>CTC	p.L58L	TMEM22_uc003erg.3_Silent_p.L58L|TMEM22_uc010hub.2_Silent_p.L58L	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	58						Golgi apparatus|integral to membrane				ovary(1)	1						AAGGTCTGCTGAGTGAAATGA	0.398													23	184					0	0	0	0	C	136573476	C	C	136573476	2	2	85	1	0	0	0	0	0	0	0	1	16209	1277	45	2		2	TMEM22	3	136573476	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	23848818	136573476	61448954	26	16984											
CLSTN2	64084	broad.mit.edu	37	chr3	140281716	140281716	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctaccgcaactggcgtcCggcttcccttgaggcccggc	4	7	12	18	5	0	1	0	1	0	0	2	1	2	1	5	4	2	3	5	4	2	3	rs139860767		TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr3:140281716C>T	uc003etn.2	+	14	2466	c.2276C>T	c.(2275-2277)CCG>CTG	p.P759L		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	759	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						AACTGGCGTCCGGCTTCCCTT	0.567										HNSCC(16;0.037)			12	55					0	0	0	0	T	140281716	T	T	140281716	3	4	85	1	0	0	0	0	1	0	0	0	3577	652	23	1	2330	1	CLSTN2	3	140281716	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	3708240	140281716	57740714	27	16985											
ZIC4	84107	broad.mit.edu	37	chr3	147113999	147113999	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaaagcgccaggaccgtgggGcgcagcgaggttcaccgtca	9	4	16	12	5	2	0	2	0	0	0	2	3	2	1	3	4	2	2	3	4	1	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr3:147113999G>A	uc003ewd.1	-	3	601	c.328C>T	c.(328-330)CCC>TCC	p.P110S	ZIC4_uc003ewc.1_Missense_Mutation_p.P40S|ZIC4_uc011bno.1_Missense_Mutation_p.P160S	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	110						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GGACCGTGGGGCGCAGCGAGG	0.706													9	52					0	0	0	0	A	147113999	A	A	147113999	3	1	85	1	0	0	0	0	1	0	0	0	17748	1203	42	4	688	4	ZIC4	3	147113999	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	6832283	147113999	50908431	28	16986											
SERPINI1	5274	broad.mit.edu	37	chr3	167512409	167512409	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcctttattttctttttaggGgaatttagtgatggctccaa	8	18	9	6	0	1	1	0	1	1	0	2	2	2	2	2	3	0	1	2	3	5	9			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr3:167512409G>T	uc003ffa.3	+	5	876	c.678G>T	c.(676-678)GGG>GGT	p.G226G	SERPINI1_uc003ffb.3_Silent_p.G226G	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	226					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						TCTTTTTAGGGGAATTTAGTG	0.299													17	30					2.35188e-11	3.15647e-11	1	0	T	167512409	T	T	167512409	2	4	85	1	0	0	0	0	0	0	0	1	14183	1246	43	4		4	SERPINI1	3	167512409	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	20398410	167512409	30510021	29	16987											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	67					0	0	0	0	A	178936091	A	A	178936091	3	1	85	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	11423682	178936091	19086339	30	16988											
WDR19	57728	broad.mit.edu	37	chr4	39233472	39233472	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatgaggctgcctggaatGagttggccagagcttgtcta	9	11	14	7	0	1	4	0	3	1	1	1	5	1	5	2	3	2	3	2	3	2	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr4:39233472G>T	uc003gtv.2	+	18	2192	c.2038G>T	c.(2038-2040)GAG>TAG	p.E680*	WDR19_uc011byi.1_Nonsense_Mutation_p.E520*|WDR19_uc003gtw.1_Nonsense_Mutation_p.E277*	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	680					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TGCCTGGAATGAGTTGGCCAG	0.433													30	35					2.61193e-14	3.60023e-14	1	0	T	39233472	T	T	39233472	4	4	85	1	0	0	0	0	0	1	0	0	17347	1291	45	2	2108	2	WDR19	4	39233472	Nonsense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08		39233472	151920804	31	16989											
ANKRD17	26057	broad.mit.edu	37	chr4	73956816	73956816	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgagggggtggtctaatagCaggggtttccattttaggag	9	12	16	4	0	1	1	0	1	1	0	2	2	2	2	1	6	1	2	1	6	3	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr4:73956816C>G	uc003hgp.2	-	29	6646	c.6529G>C	c.(6529-6531)GCT>CCT	p.A2177P	ANKRD17_uc003hgo.2_Missense_Mutation_p.A2064P|ANKRD17_uc003hgq.2_Missense_Mutation_p.A1926P|ANKRD17_uc003hgr.2_Missense_Mutation_p.A2176P	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2177					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGTCTAATAGCAGGGGTTTCC	0.507													35	132					0	0	0	0	G	73956816	G	G	73956816	3	3	85	1	0	0	0	0	1	0	0	0	646	710	25	4	1306	4	ANKRD17	4	73956816	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	34723344	73956816	117197460	32	16990											
SLC25A31	83447	broad.mit.edu	37	chr4	128651737	128651737	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgaaaaagaaggcagaaaagCggctgtttgacgcctcatcc	14	6	11	10	3	1	3	1	1	0	2	2	4	2	3	2	2	1	3	2	2	5	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr4:128651737C>T	uc003ifl.2	+	1	183	c.37C>T	c.(37-39)CGG>TGG	p.R13W		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	13					transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						GGCAGAAAAGCGGCTGTTTGA	0.567													11	64					0	0	0	0	T	128651737	T	T	128651737	3	4	85	1	0	0	0	0	1	0	0	0	14559	759	27	1	39	1	SLC25A31	4	128651737	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	54694921	128651737	62502539	33	16991											
ZNF827	152485	broad.mit.edu	37	chr4	146813423	146813423	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggatttgagattgtccttgCgagcacaccggaatggacag	10	9	14	8	2	0	1	0	1	0	1	1	6	1	4	2	3	2	1	2	3	1	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr4:146813423C>T	uc003ikn.2	-	3	1286	c.1238G>A	c.(1237-1239)CGC>CAC	p.R413H	ZNF827_uc003ikm.2_Missense_Mutation_p.R413H|ZNF827_uc010iox.2_Missense_Mutation_p.R63H	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	413	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					ATTGTCCTTGCGAGCACACCG	0.512													25	30					0	0	0	0	T	146813423	T	T	146813423	3	4	85	1	0	0	0	0	1	0	0	0	18247	768	27	1	2039	1	ZNF827	4	146813423	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	18161686	146813423	44340853	34	16992											
TMEM184C	55751	broad.mit.edu	37	chr4	148545966	148545966	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttcatagtggatagctttGaaatatcccggaattgcaat	12	15	8	6	1	1	1	1	1	0	0	2	3	2	3	1	2	2	2	1	2	6	7			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr4:148545966G>C	uc003ila.3	+	4	872	c.303G>C	c.(301-303)TTG>TTC	p.L101F		NM_018241	NP_060711	Q9NVA4	T184C_HUMAN	transmembrane protein 184C	101	Helical; (Potential).					integral to membrane					0						GGATAGCTTTGAAATATCCCG	0.333													15	30					0	0	0	0	C	148545966	C	C	148545966	3	2	85	1	0	0	0	0	1	0	0	0	16172	1281	45	2	317	2	TMEM184C	4	148545966	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	1732543	148545966	42608310	35	16993											
FHDC1	85462	broad.mit.edu	37	chr4	153896099	153896099	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgctgaccgggagctgctGaccttcttggagagctccac	6	10	12	13	1	2	3	0	2	2	1	3	5	3	4	3	2	4	4	3	2	0	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr4:153896099G>C	uc003inf.2	+	11	1731	c.1656G>C	c.(1654-1656)CTG>CTC	p.L552L		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	552					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					GGGAGCTGCTGACCTTCTTGG	0.716													3	29					0	0	0	0	C	153896099	C	C	153896099	2	2	85	1	0	0	0	0	0	0	0	1	5908	1277	45	2		2	FHDC1	4	153896099	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	5350133	153896099	37258177	36	16994											
EXOC3	11336	broad.mit.edu	37	chr5	453741	453741	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtccgccgtgaccccacCttgctggtctcagttgtcag	5	11	10	15	2	2	1	2	1	1	0	4	1	3	1	5	1	1	2	5	1	0	2	rs3822755	by1000genomes	TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:453741C>T	uc003jba.2	+	4	749	c.621C>T	c.(619-621)ACC>ACT	p.T207T		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	218					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GTGACCCCACCTTGCTGGTCT	0.547													38	89					0	0	0	0	T	453741	T	T	453741	2	4	85	1	0	0	0	0	0	0	0	1	5327	668	24	4		4	EXOC3	5	453741	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08		453741	180461519	37	16995											
KIAA0947	23379	broad.mit.edu	37	chr5	5461339	5461339	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacattgaaaccagtttttCttcctcttctaccttggtag	8	17	6	10	0	3	2	0	2	3	0	4	2	4	2	3	1	2	2	3	1	3	8			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:5461339C>T	uc003jdm.3	+	13	2114	c.1892C>T	c.(1891-1893)TCT>TTT	p.S631F		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	631										ovary(1)|central_nervous_system(1)	2						ACCAGTTTTTCTTCCTCTTCT	0.413													17	96					0	0	0	0	T	5461339	T	T	5461339	3	4	85	1	0	0	0	0	1	0	0	0	8241	913	32	2	1942	2	KIAA0947	5	5461339	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	5007598	5461339	175453921	38	16996											
PRLR	5618	broad.mit.edu	37	chr5	35070274	35070274	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actccatgcactccagtatcCatggtctggtttgcagcgaa	9	11	9	12	1	1	0	0	0	1	0	4	1	4	0	3	2	3	4	3	2	2	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:35070274C>T	uc003jjm.2	-	7	1167	c.637G>A	c.(637-639)GGA>AGA	p.G213R	PRLR_uc003jjg.1_Missense_Mutation_p.G213R|PRLR_uc003jjh.1_Missense_Mutation_p.G213R|PRLR_uc003jji.1_Missense_Mutation_p.G142R|PRLR_uc003jjj.1_Missense_Mutation_p.G213R|PRLR_uc003jjk.1_Missense_Mutation_p.G142R|PRLR_uc003jjl.3_Missense_Mutation_p.G112R|PRLR_uc010iuw.1_Missense_Mutation_p.G142R	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	213	Fibronectin type-III 2.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CTCCAGTATCCATGGTCTGGT	0.448													14	55					0	0	0	0	T	35070274	T	T	35070274	3	4	85	1	0	0	0	0	1	0	0	0	12593	603	21	4	1247	4	PRLR	5	35070274	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	29608935	35070274	145844986	39	16997											
CCL28	56477	broad.mit.edu	37	chr5	43382119	43382119	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcttaacagtatggttgtgcGggctgacacagattcttctg	8	13	12	8	1	2	2	0	1	2	1	2	2	2	2	0	2	2	4	0	2	2	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:43382119G>T	uc003jnu.2	-	3	297	c.227C>A	c.(226-228)CCG>CAG	p.P76Q	CCL28_uc003jns.2_RNA|CCL28_uc003jnt.2_RNA|CCL28_uc010ivn.2_Missense_Mutation_p.P29Q	NM_148672	NP_683513	Q9NRJ3	CCL28_HUMAN	chemokine (C-C motif) ligand 28 precursor	76					chemotaxis|immune response	extracellular space	chemokine activity			ovary(1)|kidney(1)	2						ATGGTTGTGCGGGCTGACACA	0.403													4	104					0.000602214	0.000744556	1	0	T	43382119	T	T	43382119	3	4	85	1	0	0	0	0	1	0	0	0	2913	1116	39	3	160	3	CCL28	5	43382119	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	8311845	43382119	137533141	40	16998											
ISL1	3670	broad.mit.edu	37	chr5	50685739	50685739	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agcatcatgatgaagcaactCcagcagcagcagcccaatga	15	5	9	12	0	1	3	1	3	0	0	2	3	2	3	2	0	7	5	2	0	3	0			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:50685739C>G	uc003jor.2	+	4	1286	c.738C>G	c.(736-738)CTC>CTG	p.L246L		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	246	Gln-rich.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				TGAAGCAACTCCAGCAGCAGC	0.582													6	22					0	0	0	0	G	50685739	G	G	50685739	2	3	85	1	0	0	0	0	0	0	0	1	7895	842	30	2		2	ISL1	5	50685739	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08	7303620	50685739	130229521	41	16999											
SLCO6A1	133482	broad.mit.edu	37	chr5	101813510	101813510	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaagacaggtattttgattgGaatgatataccactgctctg	13	13	9	6	0	1	3	0	2	1	1	1	4	1	4	1	2	2	2	1	2	5	6			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:101813510G>C	uc003knn.2	-	3	844	c.672C>G	c.(670-672)TTC>TTG	p.F224L	SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Missense_Mutation_p.F224L|SLCO6A1_uc003knq.2_Intron	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	224	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		ATTTTGATTGGAATGATATAC	0.353													21	76					0	0	0	0	C	101813510	C	C	101813510	3	2	85	1	0	0	0	0	1	0	0	0	14796	1165	41	2	1531	2	SLCO6A1	5	101813510	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	51127771	101813510	79101750	42	17000											
SRP19	6728	broad.mit.edu	37	chr5	112227862	112227862	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taatggagaaggatcgagctAattgtcccttctacagtaaa	14	11	9	7	1	1	1	0	0	1	1	3	4	2	2	1	2	2	2	1	2	6	6			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:112227862A>T	uc011cvv.1	+	4	856	c.601A>T	c.(601-603)AAT>TAT	p.N201Y	SRP19_uc011cvu.1_Missense_Mutation_p.N186Y|REEP5_uc011cvw.1_Intron|REEP5_uc003kqe.1_Intron|REEP5_uc011cvx.1_Intron|REEP5_uc011cvy.1_Intron|REEP5_uc011cvz.1_Intron			P09132	SRP19_HUMAN	SubName: Full=Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2;	Error:Variant_position_missing_in_P09132_after_alignment					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|mitochondrion|nucleolus|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding				0		all_cancers(142;0.00328)|all_epithelial(76;6.39e-05)|Prostate(80;0.00174)|Colorectal(10;0.00372)|Ovarian(225;0.156)		Epithelial(69;1.7e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.17e-08)|all cancers(49;3.96e-07)|Colorectal(14;0.0056)|COAD - Colon adenocarcinoma(37;0.0104)		GGATCGAGCTAATTGTCCCTT	0.413													24	68					0	0	0	0	T	112227862	T	T	112227862	3	4	85	1	0	0	0	0	1	0	0	0	15220	377	13	5		5	SRP19	5	112227862	Missense_Mutation	SNP	A	TCGA-CN-6994-01A-11D-1912-08	10414352	112227862	68687398	43	17001											
PHF15	23338	broad.mit.edu	37	chr5	133895524	133895524	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttgattttctaggatcCtcccaccactggaaggcccc	7	12	8	14	0	2	1	0	1	2	0	4	3	4	3	5	3	0	0	5	3	2	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:133895524C>T	uc003kzo.1	+	5	495	c.316C>T	c.(316-318)CTC>TTC	p.L106F	PHF15_uc011cxt.1_Missense_Mutation_p.L106F|PHF15_uc003kzk.2_Missense_Mutation_p.L122F|PHF15_uc003kzl.2_Missense_Mutation_p.L106F|PHF15_uc003kzm.2_Missense_Mutation_p.L106F|PHF15_uc003kzn.2_Missense_Mutation_p.L106F	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	106					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTCTAGGATCCTCCCACCACT	0.632													10	23					0	0	0	0	T	133895524	T	T	133895524	3	4	85	1	0	0	0	0	1	0	0	0	11881	681	24	4	330	4	PHF15	5	133895524	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	21667662	133895524	47019736	44	17002											
PCDHA1	56147	broad.mit.edu	37	chr5	140167279	140167279	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtattcgtgaaggagaacaaCccgccgggctgccacatctt	10	8	11	12	3	1	2	0	1	1	1	2	3	1	2	3	2	3	2	3	2	4	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:140167279C>T	uc003lhb.2	+	1	1404	c.1404C>T	c.(1402-1404)AAC>AAT	p.N468N	PCDHA1_uc003lha.2_Silent_p.N468N|PCDHA1_uc003lgz.2_Silent_p.N468N	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	468	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAGAACAACCCGCCGGGCT	0.667													51	51					0	0	0	0	T	140167279	T	T	140167279	2	4	85	1	0	0	0	0	0	0	0	1	11573	506	18	4		4	PCDHA1	5	140167279	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08	6271755	140167279	40747981	45	17003											
PCDH1	5097	broad.mit.edu	37	chr5	141244696	141244696	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcctctgagatgttagccatCccatcttgatgagtcactag	9	13	8	11	0	3	3	1	3	2	1	5	4	5	3	3	0	1	1	3	0	2	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:141244696C>G	uc003llq.2	-	3	1317	c.1200G>C	c.(1198-1200)GGG>GGC	p.G400G	PCDH1_uc003llp.2_Silent_p.G400G|PCDH1_uc011dbf.1_Silent_p.G378G	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	400	Extracellular (Potential).|Cadherin 4.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TGTTAGCCATCCCATCTTGAT	0.567													35	91					0	0	0	0	G	141244696	G	G	141244696	2	3	85	1	0	0	0	0	0	0	0	1	11560	842	30	2		2	PCDH1	5	141244696	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08	1077417	141244696	39670564	46	17004											
FLT4	2324	broad.mit.edu	37	chr5	180038443	180038443	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgccctcttctgagctctGagagctgcgcggggccatgc	4	9	14	14	2	3	2	0	2	3	1	3	3	3	2	2	2	5	3	2	2	0	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr5:180038443G>C	uc003mma.3	-	27	3653	c.3574C>G	c.(3574-3576)CAG>GAG	p.Q1192E	FLT4_uc003mlz.3_Missense_Mutation_p.Q1192E	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	1192	Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCTGAGCTCTGAGAGCTGCGC	0.622									Congenital_Hereditary_Lymphedema				5	78					0	0	0	0	C	180038443	C	C	180038443	3	2	85	1	0	0	0	0	1	0	0	0	5976	1299	45	2	541	2	FLT4	5	180038443	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	38793747	180038443	876817	47	17005											
NEU1	4758	broad.mit.edu	37	chr6	31828383	31828383	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgatgaggcggcccttccGtggctcccgctgtttctgtg	3	11	13	14	4	1	1	0	1	1	0	3	2	3	1	3	3	0	3	3	3	0	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr6:31828383G>A	uc003nxq.3	-	4	787	c.631C>T	c.(631-633)CGG>TGG	p.R211W	NEU1_uc010jtg.2_RNA|NEU1_uc003nxr.3_RNA|NEU1_uc010jth.2_Missense_Mutation_p.R42W|NEU1_uc003nxs.3_Missense_Mutation_p.R211W	NM_000434	NP_000425	Q99519	NEUR1_HUMAN	neuraminidase precursor	211						cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			ovary(1)	1					Oseltamivir(DB00198)|Zanamivir(DB00558)	CGGCCCTTCCGTGGCTCCCGC	0.607													21	79					0	0	0	0	A	31828383	A	A	31828383	3	1	85	1	0	0	0	0	1	0	0	0	10395	1144	40	1	628	1	NEU1	6	31828383	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08		31828383	139286684	48	17006											
FTSJD2	23070	broad.mit.edu	37	chr6	37429756	37429756	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctaatctaggaggccacttCatctgtaaaacctttgacct	11	13	6	11	0	4	1	1	1	3	0	4	2	4	2	3	2	1	1	3	2	4	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr6:37429756C>T	uc003ons.2	+	12	1456	c.1203C>T	c.(1201-1203)TTC>TTT	p.F401F	FTSJD2_uc010jwu.2_Silent_p.F345F	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	401					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GAGGCCACTTCATCTGTAAAA	0.438													36	152					0	0	0	0	T	37429756	T	T	37429756	2	4	85	1	0	0	0	0	0	0	0	1	6125	825	29	2		2	FTSJD2	6	37429756	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08	5601373	37429756	133685311	49	17007											
NFYA	4800	broad.mit.edu	37	chr6	41065110	41065110	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctaggatccaaaccaagcCgatgaagaagcaatgacaca	17	5	8	11	1	1	3	0	2	1	1	2	5	2	4	3	1	3	1	3	1	6	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr6:41065110C>T	uc003opo.2	+	10	1183	c.1005C>T	c.(1003-1005)GCC>GCT	p.A335A	NFYA_uc003opp.2_Silent_p.A306A|NFYA_uc003opq.2_Silent_p.A306A	NM_002505	NP_002496	P23511	NFYA_HUMAN	nuclear transcription factor Y, alpha isoform 1	335					transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					CAAACCAAGCCGATGAAGAAG	0.453													15	56					0	0	0	0	T	41065110	T	T	41065110	2	4	85	1	0	0	0	0	0	0	0	1	10443	639	23	1		1	NFYA	6	41065110	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08	3635354	41065110	130049957	50	17008											
SIM1	6492	broad.mit.edu	37	chr6	100896434	100896434	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtagcttgatctccgtgaCggcgctgggaggcagcgagt	6	9	17	9	4	1	2	0	2	1	0	2	4	1	3	1	3	2	4	1	3	1	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr6:100896434C>T	uc003pqj.3	-	6	871	c.664G>A	c.(664-666)GTC>ATC	p.V222I	SIM1_uc010kcu.2_Missense_Mutation_p.V222I	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	222	PAS 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		ATCTCCGTGACGGCGCTGGGA	0.602													8	7					0	0	0	0	T	100896434	T	T	100896434	3	4	85	1	0	0	0	0	1	0	0	0	14388	536	19	1	1660	1	SIM1	6	100896434	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	59831324	100896434	70218633	51	17009											
HACE1	57531	broad.mit.edu	37	chr6	105232953	105232953	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaataacatcctgacaatctGcactggcttcctgtctccct	10	12	5	14	0	2	1	0	1	2	0	5	1	4	1	3	1	2	2	3	1	3	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr6:105232953G>C	uc003pqu.1	-	12	1593	c.1316C>G	c.(1315-1317)GCA>GGA	p.A439G	HACE1_uc010kcy.1_5'UTR|HACE1_uc010kcz.1_Missense_Mutation_p.A439G|HACE1_uc010kcx.1_5'UTR|HACE1_uc003pqt.1_Missense_Mutation_p.A92G	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	439					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		CTGACAATCTGCACTGGCTTC	0.478													8	37					0	0	0	0	C	105232953	C	C	105232953	3	2	85	1	0	0	0	0	1	0	0	0	6979	1319	46	4	1465	4	HACE1	6	105232953	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	4336519	105232953	65882114	52	17010											
GPR126	57211	broad.mit.edu	37	chr6	142688950	142688950	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttgtggagcaactgccaaAggcctatcatttaactcaag	12	12	8	9	0	2	0	2	0	0	0	2	1	2	1	2	2	4	1	2	2	5	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr6:142688950A>G	uc010khc.2	+	3	759	c.348A>G	c.(346-348)AAA>AAG	p.K116K	GPR126_uc010khd.2_Silent_p.K116K|GPR126_uc010khe.2_Silent_p.K116K|GPR126_uc010khf.2_Silent_p.K116K|GPR126_uc003qix.2_Silent_p.K116K	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	116	CUB.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		CAACTGCCAAAGGCCTATCAT	0.403													3	62					0	0	0	0	G	142688950	G	G	142688950	2	3	85	1	0	0	0	0	0	0	0	1	6678	69	3	5		5	GPR126	6	142688950	Silent	SNP	A	TCGA-CN-6994-01A-11D-1912-08	37455997	142688950	28426117	53	17011											
LPA	4018	broad.mit.edu	37	chr6	160999635	160999635	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgattctgtcactggacatCgtgtcaggttgcagtactcc	7	13	10	11	2	3	0	2	0	1	0	6	2	4	1	1	2	2	3	1	2	1	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr6:160999635C>A	uc003qtl.2	-	28	4511	c.4391G>T	c.(4390-4392)CGA>CTA	p.R1464L		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3972	Kringle 35.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CACTGGACATCGTGTCAGGTT	0.527													14	68					3.27435e-08	4.30947e-08	1	0	A	160999635	A	A	160999635	3	1	85	1	0	0	0	0	1	0	0	0	8953	884	31	3	1783	3	LPA	6	160999635	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	18310685	160999635	10115432	54	17012											
DGKB	1607	broad.mit.edu	37	chr7	14188824	14188824	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accggtttttggaggcgggcCcatcagcattggggcttggt	5	11	16	9	2	1	0	1	0	0	0	1	1	1	1	2	7	1	3	2	7	0	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr7:14188824C>G	uc003ssz.2	-	25	2534	c.2347G>C	c.(2347-2349)GGC>CGC	p.G783R	DGKB_uc011jxt.1_Missense_Mutation_p.G764R	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	783					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	GGAGGCGGGCCCATCAGCATT	0.338													10	101					0	0	0	0	G	14188824	G	G	14188824	3	3	85	1	0	0	0	0	1	0	0	0	4488	623	22	4	71	4	DGKB	7	14188824	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08		14188824	144949839	55	17013											
AQP1	358	broad.mit.edu	37	chr7	30951587	30951587	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggccgagttcctggccacGaccctctttgtcttcatcag	5	12	10	14	2	4	0	2	0	2	0	5	2	5	0	4	2	0	1	4	2	0	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr7:30951587G>T	uc003tbv.1	+	1	120	c.63G>T	c.(61-63)ACG>ACT	p.T21T	AQP1_uc011kac.1_Intron	NM_198098	NP_932766	P29972	AQP1_HUMAN	aquaporin 1	21	Helical; Name=Helix 1.				ammonium transport|cell volume homeostasis|cellular hyperosmotic response|cellular response to cAMP|cellular response to copper ion|cellular response to dexamethasone stimulus|cellular response to hydrogen peroxide|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to mercury ion|cellular response to nitric oxide|cellular response to retinoic acid|cellular response to salt stress|cellular response to UV|cerebrospinal fluid secretion|cGMP biosynthetic process|establishment or maintenance of actin cytoskeleton polarity|lateral ventricle development|maintenance of symbiont-containing vacuole via substance secreted by host|negative regulation of apoptosis|odontogenesis|pancreatic juice secretion|positive regulation of angiogenesis|positive regulation of fibroblast proliferation|positive regulation of saliva secretion|renal water transport|response to drug|transepithelial water transport	apical plasma membrane|basal plasma membrane|brush border membrane|cytoplasm|integral to plasma membrane|nuclear membrane|sarcolemma|symbiont-containing vacuole	ammonia transmembrane transporter activity|carbon dioxide transmembrane transporter activity|glycerol transmembrane transporter activity|intracellular cGMP activated cation channel activity|nitric oxide transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|protein binding|water channel activity				0		Melanoma(862;0.16)			Acetazolamide(DB00819)	TCCTGGCCACGACCCTCTTTG	0.622													16	37					3.45872e-05	4.38247e-05	1	0	T	30951587	T	T	30951587	2	4	85	1	0	0	0	0	0	0	0	1	821	1045	37	3		3	AQP1	7	30951587	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	16762763	30951587	128187076	56	17014											
PKD1L1	168507	broad.mit.edu	37	chr7	47915768	47915768	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctcccatggtacaaagtGtgtttggaggtgtttcctat	7	16	10	8	0	1	0	0	0	1	0	4	1	3	1	2	3	1	3	2	3	3	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr7:47915768G>A	uc003tny.1	-	23	3711	c.3711C>T	c.(3709-3711)CAC>CAT	p.H1237H		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1237	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GGTACAAAGTGTGTTTGGAGG	0.418													7	36					0	0	0	0	A	47915768	A	A	47915768	2	1	85	1	0	0	0	0	0	0	0	1	12019	1368	48	4		4	PKD1L1	7	47915768	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	16964181	47915768	111222895	57	17015											
CCDC146	57639	broad.mit.edu	37	chr7	76891594	76891594	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggatgcacttaggcaaacTcaagcactgcatcaaaggct	13	8	10	10	0	2	0	2	0	0	0	2	1	2	1	0	3	4	5	0	3	4	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr7:76891594T>C	uc003uga.2	+	9	1270	c.1143T>C	c.(1141-1143)ACT>ACC	p.T381T	CCDC146_uc010ldp.2_Silent_p.T127T	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	381										ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				TTAGGCAAACTCAAGCACTGC	0.378													11	51					0	0	0	0	C	76891594	C	C	76891594	2	2	85	1	0	0	0	0	0	0	0	1	2792	1538	54	5		5	CCDC146	7	76891594	Silent	SNP	T	TCGA-CN-6994-01A-11D-1912-08	28975826	76891594	82247069	58	17016											
PIK3CG	5294	broad.mit.edu	37	chr7	106508473	106508473	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccagcggcagctcacggCgctgattggctatgacgtca	7	9	12	13	4	2	2	2	2	0	0	3	2	3	2	1	3	2	4	1	3	1	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr7:106508473C>T	uc003vdv.3	+	2	552	c.467C>T	c.(466-468)GCG>GTG	p.A156V	PIK3CG_uc003vdu.2_Missense_Mutation_p.A156V|PIK3CG_uc003vdw.2_Missense_Mutation_p.A156V	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	156					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CAGCTCACGGCGCTGATTGGC	0.682													4	25					0	0	0	0	T	106508473	T	T	106508473	3	4	85	1	0	0	0	0	1	0	0	0	11971	768	27	1	469	1	PIK3CG	7	106508473	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	29616879	106508473	52630190	59	17017											
KCND2	3751	broad.mit.edu	37	chr7	119914945	119914945	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagcagtatttctttgacCgtgacccagacatcttccgc	8	12	7	14	2	3	3	1	2	2	1	4	3	4	3	3	0	1	2	3	0	1	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr7:119914945C>G	uc003vjj.1	+	1	1224	c.259C>G	c.(259-261)CGT>GGT	p.R87G		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	87	Cytoplasmic (Potential).|Interaction with KCNIP1 (By similarity).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					TTTCTTTGACCGTGACCCAGA	0.527													39	119					0	0	0	0	G	119914945	G	G	119914945	3	3	85	1	0	0	0	0	1	0	0	0	8058	652	23	3	261	3	KCND2	7	119914945	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	13406472	119914945	39223718	60	17018											
NUP205	23165	broad.mit.edu	37	chr7	135272382	135272382	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgattcacatgagtatgcaGatgggtaatgaaccccccat	13	10	9	9	0	1	4	1	3	0	1	1	4	1	4	3	1	2	3	3	1	3	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr7:135272382G>C	uc003vsw.2	+	9	1309	c.1278G>C	c.(1276-1278)CAG>CAC	p.Q426H	NUP205_uc011kqa.1_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	426					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						TGAGTATGCAGATGGGTAATG	0.373													6	45					0	0	0	0	C	135272382	C	C	135272382	3	2	85	1	0	0	0	0	1	0	0	0	10813	933	33	2	1312	2	NUP205	7	135272382	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	15357437	135272382	23866281	61	17019											
STC1	6781	broad.mit.edu	37	chr8	23702400	23702400	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcgtctcctgttgaagtcAgctcgtgggtgtgtttgggc	3	14	16	8	2	2	1	1	1	1	0	4	1	2	1	1	2	2	3	1	2	1	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr8:23702400A>C	uc003xdw.1	-	4	911	c.627T>G	c.(625-627)GCT>GCG	p.A209A		NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor	209					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TGTTGAAGTCAGCTCGTGGGT	0.552													19	91					0	0	0	0	C	23702400	C	C	23702400	2	2	85	1	0	0	0	0	0	0	0	1	15341	175	7	5		5	STC1	8	23702400	Silent	SNP	A	TCGA-CN-6994-01A-11D-1912-08		23702400	122661622	62	17020											
MYST3	7994	broad.mit.edu	37	chr8	41791310	41791310	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagggctattatgttctgaCgcatgacagtcttcaaccat	11	13	8	9	1	3	2	1	2	2	0	3	2	3	2	1	1	1	3	1	1	4	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr8:41791310C>T	uc010lxb.2	-	18	4972	c.4428G>A	c.(4426-4428)GCG>GCA	p.A1476A	MYST3_uc010lxc.2_Silent_p.A1476A|MYST3_uc003xon.3_Silent_p.A1476A	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1476					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TATGTTCTGACGCATGACAGT	0.562													30	79					0	0	0	0	T	41791310	T	T	41791310	2	4	85	1	0	0	0	0	0	0	0	1	10157	523	19	1		1	MYST3	8	41791310	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08	18088910	41791310	104572712	63	17021											
SULF1	23213	broad.mit.edu	37	chr8	70515533	70515533	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtctgtcctcaaacttctgGacccagaaaagccaggtaac	13	8	8	12	0	3	1	1	0	2	1	4	2	4	2	3	2	3	1	3	2	4	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr8:70515533G>A	uc010lza.1	+	11	1885	c.1168G>A	c.(1168-1170)GAC>AAC	p.D390N	SULF1_uc003xyd.2_Missense_Mutation_p.D390N|SULF1_uc003xye.2_Missense_Mutation_p.D390N|SULF1_uc003xyf.2_Missense_Mutation_p.D390N|SULF1_uc003xyg.2_Missense_Mutation_p.D390N|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	390					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CAAACTTCTGGACCCAGAAAA	0.552													7	124					0	0	0	0	A	70515533	A	A	70515533	3	1	85	1	0	0	0	0	1	0	0	0	15436	1174	41	2	1194	2	SULF1	8	70515533	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	28724223	70515533	75848489	64	17022											
FABP12	646486	broad.mit.edu	37	chr8	82441795	82441795	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctccatctgtactgatggTcacagtgggttttgccaaac	9	13	9	10	0	3	1	1	1	2	0	4	1	3	1	2	2	3	2	2	2	2	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr8:82441795T>C	uc011lfp.1	-	2	124	c.124A>G	c.(124-126)ACC>GCC	p.T42A	FABP12_uc003ycg.3_RNA	NM_001105281	NP_001098751	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	42							lipid binding|transporter activity				0						GTACTGATGGTCACAGTGGGT	0.383													17	87					0	0	0	0	C	82441795	C	C	82441795	3	2	85	1	0	0	0	0	1	0	0	0	5384	1667	58	5	308	5	FABP12	8	82441795	Missense_Mutation	SNP	T	TCGA-CN-6994-01A-11D-1912-08	11926262	82441795	63922227	65	17023											
SLC10A5	347051	broad.mit.edu	37	chr8	82606646	82606646	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaacccgcaaaatggcaTcagaaaaaactgtgtaactg	19	6	8	8	1	1	2	1	0	0	2	1	2	1	2	1	1	3	3	1	1	8	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr8:82606646T>G	uc011lfs.1	-	1	562	c.562A>C	c.(562-564)ATG>CTG	p.M188L		NM_001010893	NP_001010893	Q5PT55	NTCP5_HUMAN	solute carrier family 10 (sodium/bile acid	188	Helical; (Potential).					integral to membrane	bile acid:sodium symporter activity				0						CAAAATGGCATCAGAAAAAAC	0.463													20	102					0	0	0	0	G	82606646	G	G	82606646	3	3	85	1	0	0	0	0	1	0	0	0	14442	1435	50	5	756	5	SLC10A5	8	82606646	Missense_Mutation	SNP	T	TCGA-CN-6994-01A-11D-1912-08	164851	82606646	63757376	66	17024											
LRRCC1	85444	broad.mit.edu	37	chr8	86048078	86048078	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgacaagcagaagagtattCaaatagaacttctcaagcac	18	8	7	8	0	2	4	2	1	1	3	3	4	2	4	0	0	3	3	0	0	7	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr8:86048078C>G	uc003ycw.2	+	14	2363	c.2209C>G	c.(2209-2211)CAA>GAA	p.Q737E	LRRCC1_uc010maa.1_Missense_Mutation_p.Q438E|LRRCC1_uc003ycx.2_Missense_Mutation_p.Q644E|LRRCC1_uc003ycy.2_Missense_Mutation_p.Q717E	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	737					cell division|mitosis	centriole|nucleus					0						GAAGAGTATTCAAATAGAACT	0.313													6	76					0	0	0	0	G	86048078	G	G	86048078	3	3	85	1	0	0	0	0	1	0	0	0	9076	827	29	2	2263	2	LRRCC1	8	86048078	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	3441432	86048078	60315944	67	17025											
ZFAT	57623	broad.mit.edu	37	chr8	135602519	135602519	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcacaaccttaccaggatggTtggtcttgatatgtgacttt	9	14	10	8	0	1	2	0	2	1	0	1	3	1	3	2	3	2	2	2	3	3	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr8:135602519T>A	uc003yup.2	-	8	2730	c.2555A>T	c.(2554-2556)AAC>ATC	p.N852I	ZFAT_uc003yun.2_Missense_Mutation_p.N840I|ZFAT_uc003yuo.2_Missense_Mutation_p.N840I|ZFAT_uc010meh.2_Missense_Mutation_p.N840I|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.N840I|ZFAT_uc010mej.2_Missense_Mutation_p.N790I	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	852	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			ACCAGGATGGTTGGTCTTGAT	0.308													17	102					0	0	0	0	A	135602519	A	A	135602519	3	1	85	1	0	0	0	0	1	0	0	0	17699	1725	60	5	1212	5	ZFAT	8	135602519	Missense_Mutation	SNP	T	TCGA-CN-6994-01A-11D-1912-08	49554441	135602519	10761503	68	17026											
CNTLN	54875	broad.mit.edu	37	chr9	17388167	17388167	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattctctaccagaacagctCtttagatctggtgaagatga	12	13	8	8	0	3	5	0	2	3	3	4	5	3	5	1	1	3	1	1	1	5	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr9:17388167C>G	uc003zmz.2	+	14	2021	c.1995C>G	c.(1993-1995)CTC>CTG	p.L665L	CNTLN_uc003zmy.2_Silent_p.L665L|CNTLN_uc010mio.2_Silent_p.L344L	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	665						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		CAGAACAGCTCTTTAGATCTG	0.358													14	101					0	0	0	0	G	17388167	G	G	17388167	2	3	85	1	0	0	0	0	0	0	0	1	3654	900	32	2		2	CNTLN	9	17388167	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08		17388167	123825264	69	17027											
CCDC107	203260	broad.mit.edu	37	chr9	35661158	35661158	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagggacgacagctgaaggtCgactaaaacaaagtctgttt	14	8	12	7	2	1	1	0	1	1	0	2	5	1	2	0	2	2	2	0	2	4	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr9:35661158C>T	uc011lox.1	+	5	892	c.826C>T	c.(826-828)CGA>TGA	p.R276*	CCDC107_uc011loy.1_Nonsense_Mutation_p.R249*|CCDC107_uc003zxj.2_3'UTR|CCDC107_uc003zxk.2_3'UTR|C9orf100_uc003zxl.2_Intron|C9orf100_uc003zxm.1_3'UTR	NM_174923	NP_777583	Q8WV48	CC107_HUMAN	coiled-coil domain containing 107 precursor	276						integral to membrane					0	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGCTGAAGGTCGACTAAAACA	0.552													11	51					0	0	0	0	T	35661158	T	T	35661158	4	4	85	1	0	0	0	0	0	1	0	0	2754	876	31	1	844	1	CCDC107	9	35661158	Nonsense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	18272991	35661158	105552273	70	17028											
RNF20	56254	broad.mit.edu	37	chr9	104319876	104319876	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgttgactctgaagactCaggtaattaggatgagtaga	13	11	13	4	0	2	5	1	3	1	2	2	6	2	6	0	3	0	3	0	3	4	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr9:104319876C>T	uc004bbn.2	+	16	2470	c.2380C>T	c.(2380-2382)CAG>TAG	p.Q794*		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	794	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		TCTGAAGACTCAGGTAATTAG	0.333													7	30					0	0	0	0	T	104319876	T	T	104319876	4	4	85	1	0	0	0	0	0	1	0	0	13538	827	29	2	2438	2	RNF20	9	104319876	Nonsense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	68658718	104319876	36893555	71	17029											
GRIN3A	116443	broad.mit.edu	37	chr9	104335610	104335610	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagatacatttagggagtctGctttcccattggtggtccgc	7	13	12	9	1	1	1	0	0	1	1	3	3	3	2	2	3	2	1	2	3	2	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr9:104335610G>T	uc004bbp.1	-	9	3795	c.3194C>A	c.(3193-3195)GCA>GAA	p.A1065E	GRIN3A_uc004bbo.1_Missense_Mutation_p.A140E	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	1065	Cytoplasmic (Potential).|Potential.				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TAGGGAGTCTGCTTTCCCATT	0.567													40	69					5.71845e-15	7.99016e-15	1	0	T	104335610	T	T	104335610	3	4	85	1	0	0	0	0	1	0	0	0	6822	1319	46	4	157	4	GRIN3A	9	104335610	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	15734	104335610	36877821	72	17030											
RAD23B	5887	broad.mit.edu	37	chr9	110073972	110073972	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttttgtagtacatcgggTgattcttctcggtcaaacct	7	16	8	10	2	3	1	1	1	2	0	6	1	4	1	2	2	2	2	2	2	3	6			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr9:110073972T>C	uc004bde.2	+	5	874	c.507T>C	c.(505-507)GGT>GGC	p.G169G	RAD23B_uc011lwa.1_Silent_p.G169G|RAD23B_uc011lwb.1_Silent_p.G148G	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	169					nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						GTACATCGGGTGATTCTTCTC	0.289								Direct_reversal_of_damage|NER					18	18					0	0	0	0	C	110073972	C	C	110073972	2	2	85	1	0	0	0	0	0	0	0	1	13048	1683	59	5		5	RAD23B	9	110073972	Silent	SNP	T	TCGA-CN-6994-01A-11D-1912-08	5738362	110073972	31139459	73	17031											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112899838	112899838	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggagaatttacgagcgccCgggctgtcctcactgtggtc	7	10	13	11	3	1	1	1	0	0	1	3	3	2	1	2	3	2	1	2	3	2	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr9:112899838C>A	uc004bei.2	+	9	2902	c.2710C>A	c.(2710-2712)CGG>AGG	p.R904R	PALM2-AKAP2_uc004bek.3_Silent_p.R672R|PALM2-AKAP2_uc004bej.3_Silent_p.R672R|PALM2-AKAP2_uc004bel.1_Silent_p.R482R|AKAP2_uc011lwi.1_Silent_p.R530R|AKAP2_uc004bem.2_Silent_p.R530R|PALM2-AKAP2_uc010mtw.1_Silent_p.R490R|AKAP2_uc011lwj.1_Silent_p.R441R|PALM2-AKAP2_uc004ben.2_Silent_p.R441R	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	441							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						TACGAGCGCCCGGGCTGTCCT	0.532													43	79					6.4771e-29	9.37112e-29	1	0	A	112899838	A	A	112899838	2	1	85	1	0	0	0	0	0	0	0	1	11464	643	23	3		3	PALM2-AKAP2	9	112899838	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08	2825866	112899838	28313593	74	17032											
TNC	3371	broad.mit.edu	37	chr9	117783505	117783505	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agcttcatctcagcaaactgGattgagtgttcgtggccctt	8	13	10	10	1	2	1	2	1	1	0	4	2	2	2	1	2	3	3	1	2	1	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr9:117783505G>C	uc004bjj.3	-	28	6899	c.6537C>G	c.(6535-6537)ATC>ATG	p.I2179M	TNC_uc010mvf.2_Missense_Mutation_p.I1906M	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	2179	Fibrinogen C-terminal.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						CAGCAAACTGGATTGAGTGTT	0.423													15	80					0	0	0	0	C	117783505	C	C	117783505	3	2	85	1	0	0	0	0	1	0	0	0	16336	1164	41	2	72	2	TNC	9	117783505	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	4883667	117783505	23429926	75	17033											
NOTCH1	4851	broad.mit.edu	37	chr9	139418373	139418373	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtcccggcgttcttgcaggGggtgctgaggcacgggttgg	3	10	19	9	3	1	1	0	1	1	0	2	1	2	1	1	6	2	5	1	6	0	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr9:139418373G>T	uc004chz.2	-	3	199	c.199C>A	c.(199-201)CCC>ACC	p.P67T		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	67	Extracellular (Potential).|EGF-like 2.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TTCTTGCAGGGGGTGCTGAGG	0.672			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			5	7					0.000602214	0.000744556	1	0	T	139418373	T	T	139418373	3	4	85	1	0	0	0	0	1	0	0	0	10601	1232	43	4	7596	4	NOTCH1	9	139418373	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	21634868	139418373	1795058	76	17034											
RET	5979	broad.mit.edu	37	chr10	43609084	43609086	+	In_Frame_Del	DEL	GAG	-	-																															gcacctgcaactgcttccctGaggaggagaagtgcttctgc																										TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr10:43609084_43609086delGAG	uc001jal.2	+	10	2030_2032	c.1840_1842delGAG	c.(1840-1842)GAGdel	p.E616del	RET_uc001jak.1_In_Frame_Del_p.E616del|RET_uc010qez.1_In_Frame_Del_p.E362del	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	616	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity	p.F612_C620del(1)		thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CTGCTTCCCTGAGGAGGAGAAGT	0.64		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				---	---	---								-	43609086	-	-	43609084	7	5	85	1	0	1	0	1	0	0	0	0	13300	1291	45	0	1878	0	RET	10	43609084	In_Frame_Del	DEL	GAG	TCGA-CN-6994-01A-11D-1912-08		43609084	91925663	77	17035											
PCDH15	65217	broad.mit.edu	37	chr10	55912867	55912867	+	Missense_Mutation	SNP	C	T	T																															taatataaattaccttcgctCtgcaggaggagcattatccg																										TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr10:55912867C>T	uc001jju.1	-	14	2172	c.1777G>A	c.(1777-1779)GAG>AAG	p.E593K	PCDH15_uc010qhq.1_Missense_Mutation_p.E598K|PCDH15_uc010qhr.1_Missense_Mutation_p.E593K|PCDH15_uc010qhs.1_Missense_Mutation_p.E605K|PCDH15_uc010qht.1_Missense_Mutation_p.E600K|PCDH15_uc010qhu.1_Missense_Mutation_p.E593K|PCDH15_uc001jjv.1_Missense_Mutation_p.E571K|PCDH15_uc010qhv.1_Missense_Mutation_p.E593K|PCDH15_uc010qhw.1_Missense_Mutation_p.E556K|PCDH15_uc010qhx.1_Missense_Mutation_p.E593K|PCDH15_uc010qhy.1_Missense_Mutation_p.E598K|PCDH15_uc010qhz.1_Missense_Mutation_p.E593K|PCDH15_uc010qia.1_Missense_Mutation_p.E571K|PCDH15_uc010qib.1_Missense_Mutation_p.E571K|PCDH15_uc001jjw.2_Missense_Mutation_p.E593K	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	593	Cadherin 5.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TACCTTCGCTCTGCAGGAGGA	0.458										HNSCC(58;0.16)			12	45					0	0	0	0	T	55912867	T	T	55912867	3	4	85	1	0	0	0	0	1	0	0	0	11565	922	32	2	5789	2	PCDH15	10	55912867	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	12303783	55912867	79621880	78	17036	35	2									
PCDH15	65217	broad.mit.edu	37	chr10	55912869	55912869	+	Missense_Mutation	SNP	G	T	T																															atataaattaccttcgctctGcaggaggagcattatccgct																										TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr10:55912869G>T	uc001jju.1	-	14	2170	c.1775C>A	c.(1774-1776)GCA>GAA	p.A592E	PCDH15_uc010qhq.1_Missense_Mutation_p.A597E|PCDH15_uc010qhr.1_Missense_Mutation_p.A592E|PCDH15_uc010qhs.1_Missense_Mutation_p.A604E|PCDH15_uc010qht.1_Missense_Mutation_p.A599E|PCDH15_uc010qhu.1_Missense_Mutation_p.A592E|PCDH15_uc001jjv.1_Missense_Mutation_p.A570E|PCDH15_uc010qhv.1_Missense_Mutation_p.A592E|PCDH15_uc010qhw.1_Missense_Mutation_p.A555E|PCDH15_uc010qhx.1_Missense_Mutation_p.A592E|PCDH15_uc010qhy.1_Missense_Mutation_p.A597E|PCDH15_uc010qhz.1_Missense_Mutation_p.A592E|PCDH15_uc010qia.1_Missense_Mutation_p.A570E|PCDH15_uc010qib.1_Missense_Mutation_p.A570E|PCDH15_uc001jjw.2_Missense_Mutation_p.A592E	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	592	Cadherin 5.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CCTTCGCTCTGCAGGAGGAGC	0.458										HNSCC(58;0.16)			12	47					5.16669e-11	6.88892e-11	1	0	T	55912869	T	T	55912869	3	4	85	1	0	0	0	0	1	0	0	0	11565	1319	46	4	5791	4	PCDH15	10	55912869	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	2	55912869	79621878	79	17037	35	2									
LRRTM3	347731	broad.mit.edu	37	chr10	68687032	68687032	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agctgattcttagttccaatAgaatctcctattttcttaac	11	17	4	9	0	3	2	0	1	3	1	5	2	4	2	2	0	2	2	2	0	6	8			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr10:68687032A>G	uc001jmz.1	+	2	908	c.358A>G	c.(358-360)AGA>GGA	p.R120G	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.R120G	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	120	LRR 3.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TAGTTCCAATAGAATCTCCTA	0.388													25	99					0	0	0	0	G	68687032	G	G	68687032	3	3	85	1	0	0	0	0	1	0	0	0	9091	412	15	5	364	5	LRRTM3	10	68687032	Missense_Mutation	SNP	A	TCGA-CN-6994-01A-11D-1912-08	12774163	68687032	66847715	80	17038											
EXOC6	54536	broad.mit.edu	37	chr10	94708041	94708043	+	In_Frame_Del	DEL	GAA	-	-																															ttcctaacagggacatttttGaagaagataattacagcccc																										TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr10:94708041_94708043delGAA	uc001kig.2	+	14	1387_1389	c.1321_1323delGAA	c.(1321-1323)GAAdel	p.E442del	EXOC6_uc010qnr.1_In_Frame_Del_p.E458del|EXOC6_uc001kie.2_In_Frame_Del_p.E437del|EXOC6_uc009xub.2_In_Frame_Del_p.E442del|EXOC6_uc009xuc.2_In_Frame_Del_p.E339del|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_In_Frame_Del_p.E16del	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	442					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				GGACATTTTTGAAGAAGATAATT	0.325													---	---	---								-	94708043	-	-	94708041	7	5	85	1	0	1	0	1	0	0	0	0	5332	1291	45	0	1465	0	EXOC6	10	94708041	In_Frame_Del	DEL	GAA	TCGA-CN-6994-01A-11D-1912-08	26021009	94708041	40826706	81	17039											
C10orf2	56652	broad.mit.edu	37	chr10	102748351	102748351	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggaagacttccaggccagCgtggaggggcgaggggatgg	8	5	21	7	2	0	1	0	0	0	1	1	5	1	4	2	8	1	0	2	8	1	1	rs148234280		TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr10:102748351C>T	uc001ksf.2	+	1	1059	c.384C>T	c.(382-384)AGC>AGT	p.S128S	MRPL43_uc001kry.1_5'Flank|MRPL43_uc010qpu.1_5'Flank|MRPL43_uc001krz.1_5'Flank|MRPL43_uc001ksa.1_5'Flank|MRPL43_uc001ksb.1_5'Flank|MRPL43_uc001ksd.1_5'Flank|MRPL43_uc001ksc.2_5'Flank|MRPL43_uc001kse.2_5'Flank|C10orf2_uc001ksg.2_Silent_p.S128S|C10orf2_uc001ksi.2_Intron|C10orf2_uc010qpv.1_Intron|C10orf2_uc001ksh.2_Intron	NM_021830	NP_068602	Q96RR1	PEO1_HUMAN	twinkle isoform A	128					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			ovary(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TCCAGGCCAGCGTGGAGGGGC	0.582													25	167					0	0	0	0	T	102748351	T	T	102748351	2	4	85	1	0	0	0	0	0	0	0	1	1603	767	27	1		1	C10orf2	10	102748351	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08	8040310	102748351	32786396	82	17040											
SORCS3	22986	broad.mit.edu	37	chr10	107012616	107012616	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcttttcattcttccaccCaagaacctgacagagaggag	12	9	9	11	0	2	3	1	1	1	2	3	6	3	4	3	1	2	1	3	1	2	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr10:107012616C>A	uc001kyi.1	+	23	3416	c.3189C>A	c.(3187-3189)CCC>CCA	p.P1063P	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1063	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TTCTTCCACCCAAGAACCTGA	0.517													11	56					6.40141e-05	8.06104e-05	1	0	A	107012616	A	A	107012616	2	1	85	1	0	0	0	0	0	0	0	1	14996	581	21	4		4	SORCS3	10	107012616	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08	4264265	107012616	28522131	83	17041											
B4GALNT4	338707	broad.mit.edu	37	chr11	376312	376312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggatgaggatgaagaagacGaggtgcagcgccgagccttc	11	5	17	8	3	0	4	0	2	0	2	1	8	0	6	2	3	3	1	2	3	2	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr11:376312G>A	uc001lpb.2	+	13	1267	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	420	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGAAGAAGACGAGGTGCAGCG	0.642													5	29					0	0	0	0	A	376312	A	A	376312	3	1	85	1	0	0	0	0	1	0	0	0	1271	1059	37	1	1308	1	B4GALNT4	11	376312	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08		376312	134630204	84	17042											
ILK	3611	broad.mit.edu	37	chr11	6631166	6631166	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatctgttttctcttcctcaGattgatgaggacatgactgc	8	16	8	9	0	3	4	1	3	2	1	5	5	4	5	1	1	1	1	1	1	1	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr11:6631166G>A	uc001mee.2	+	11	1114	c.979_splice	c.e11-1	p.I327_splice	ILK_uc001mef.2_Splice_Site_p.I327_splice|ILK_uc010rap.1_Splice_Site_p.I193_splice|ILK_uc010raq.1_Splice_Site_p.I266_splice|ILK_uc001meg.2_Splice_Site_p.I173_splice|ILK_uc001meh.2_Splice_Site_p.I327_splice|ILK_uc001mei.2_5'Flank	NM_001014794	NP_001014794	Q13418	ILK_HUMAN	integrin-linked kinase						cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		CTCTTCCTCAGATTGATGAGG	0.512													6	103					0	0	0	0	A	6631166	A	A	6631166	5	1	85	1	0	0	0	0	0	0	1	0	7752	956	33	2	1016	2	ILK	11	6631166	Splice_Site	SNP	G	TCGA-CN-6994-01A-11D-1912-08	6254854	6631166	128375350	85	17043											
C11orf41	25758	broad.mit.edu	37	chr11	33566766	33566766	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagtcacggccgcgctgaCatccattacagcctcagtga	10	7	10	14	3	2	2	2	2	0	0	3	3	3	2	3	1	2	1	3	1	1	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr11:33566766C>A	uc001mup.3	+	2	2478	c.2354C>A	c.(2353-2355)ACA>AAA	p.T785K	C11orf41_uc001mun.1_Missense_Mutation_p.T785K	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	779						integral to membrane				ovary(2)	2						GCCGCGCTGACATCCATTACA	0.602													30	56					7.01153e-11	9.28801e-11	1	0	A	33566766	A	A	33566766	3	1	85	1	0	0	0	0	1	0	0	0	1646	478	17	4	2360	4	C11orf41	11	33566766	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	26935600	33566766	101439750	86	17044											
MAPK8IP1	9479	broad.mit.edu	37	chr11	45926374	45926374	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtcaaggccgatgactccCaggaggccaaggtgacttct	9	7	13	12	2	2	2	1	2	1	0	3	4	3	3	3	4	0	0	3	4	2	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr11:45926374C>A	uc001nbr.2	+	9	2052	c.1882C>A	c.(1882-1884)CAG>AAG	p.Q628K		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	628	PID.				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		CGATGACTCCCAGGAGGCCAA	0.612													13	213					2.27111e-07	2.96991e-07	1	0	A	45926374	A	A	45926374	3	1	85	1	0	0	0	0	1	0	0	0	9337	595	21	4	1916	4	MAPK8IP1	11	45926374	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	12359608	45926374	89080142	87	17045											
CEP57	9702	broad.mit.edu	37	chr11	95564382	95564382	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacatgcaaagcatacagAattcattacaaagcagtagt	18	8	8	7	0	1	1	1	0	0	1	1	2	1	2	0	1	5	4	0	1	6	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr11:95564382A>G	uc001pfp.1	+	11	1686	c.1465A>G	c.(1465-1467)AAT>GAT	p.N489D	CEP57_uc010ruh.1_Missense_Mutation_p.N480D|CEP57_uc010rui.1_Missense_Mutation_p.N463D|CEP57_uc009ywn.1_Missense_Mutation_p.N337D|CEP57_uc001pfq.1_Missense_Mutation_p.N463D|CEP57_uc001pfr.1_Missense_Mutation_p.N337D	NM_014679	NP_055494	Q86XR8	CEP57_HUMAN	translokin	489	Mediates interaction with microtubules (By similarity).|Potential.				fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AAGCATACAGAATTCATTACA	0.343									Mosaic_Variegated_Aneuploidy_Syndrome				17	8					0	0	0	0	G	95564382	G	G	95564382	3	3	85	1	0	0	0	0	1	0	0	0	3271	246	9	5	1507	5	CEP57	11	95564382	Missense_Mutation	SNP	A	TCGA-CN-6994-01A-11D-1912-08	49638008	95564382	39442134	88	17046											
TBCEL	219899	broad.mit.edu	37	chr11	120957653	120957653	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaagaaacagttaaaaactCtagtacaattacccacaagc	20	8	4	9	0	1	1	0	0	1	1	1	1	1	1	1	0	5	2	1	0	11	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr11:120957653C>G	uc009zay.2	+	8	1201	c.1123C>G	c.(1123-1125)CTA>GTA	p.L375V	TBCEL_uc001pxo.2_Missense_Mutation_p.L375V|TBCEL_uc001pxp.2_Missense_Mutation_p.L231V|TBCEL_uc001pxq.2_RNA	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	375	Ubiquitin-like.|Potential.					cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		GTTAAAAACTCTAGTACAATT	0.433													4	14					0	0	0	0	G	120957653	G	G	120957653	3	3	85	1	0	0	0	0	1	0	0	0	15701	912	32	2	1149	2	TBCEL	11	120957653	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	25393271	120957653	14048863	89	17047											
OR10G4	390264	broad.mit.edu	37	chr11	123886869	123886869	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacacctcagccaacgtgatGgtcatctttgtggacattgg	9	11	11	10	1	3	1	2	1	1	0	3	3	3	2	2	3	2	0	2	3	1	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr11:123886869G>T	uc010sac.1	+	1	588	c.588G>T	c.(586-588)ATG>ATT	p.M196I		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CCAACGTGATGGTCATCTTTG	0.547													30	109					5.91797e-21	8.44241e-21	1	0	T	123886869	T	T	123886869	3	4	85	1	0	0	0	0	1	0	0	0	10955	1348	47	4	590	4	OR10G4	11	123886869	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	2929216	123886869	11119647	90	17048											
HDAC7	51564	broad.mit.edu	37	chr12	48196010	48196010	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgggtttgactcttacctgCgccagtggggctgcagtagt	5	11	14	11	2	1	1	0	1	1	0	1	1	1	1	3	3	3	4	3	3	2	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr12:48196010C>T	uc010slo.1	-	2	262	c.67G>A	c.(67-69)GCA>ACA	p.A23T	HDAC7_uc001rqj.3_Missense_Mutation_p.A23T|HDAC7_uc001rqk.3_Intron	NM_015401	NP_056216	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		CTCTTACCTGCGCCAGTGGGG	0.602											OREG0021756	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	21					0	0	0	0	T	48196010	T	T	48196010	3	4	85	1	0	0	0	0	1	0	0	0	7051	768	27	1	3008	1	HDAC7	12	48196010	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08		48196010	85655885	91	17049											
KIAA0748	9840	broad.mit.edu	37	chr12	55356372	55356372	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagaggctctttcttgctCtgctctttcttttccagaaa	7	16	8	10	0	5	2	0	0	5	2	6	3	6	3	1	2	2	3	1	2	2	5			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr12:55356372C>A	uc001sgn.3	-	9	1420	c.1310G>T	c.(1309-1311)AGA>ATA	p.R437I	KIAA0748_uc001sgl.3_Missense_Mutation_p.R299I|KIAA0748_uc001sgm.3_Missense_Mutation_p.R184I|KIAA0748_uc010spb.1_Missense_Mutation_p.R184I|KIAA0748_uc010spc.1_Missense_Mutation_p.R299I|KIAA0748_uc010spd.1_Missense_Mutation_p.R437I|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	437										ovary(1)|central_nervous_system(1)	2						CTTTCTTGCTCTGCTCTTTCT	0.493													39	212					2.75727e-19	3.90614e-19	1	0	A	55356372	A	A	55356372	3	1	85	1	0	0	0	0	1	0	0	0	8229	913	32	2	263	2	KIAA0748	12	55356372	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	7160362	55356372	78495523	92	17050											
PA2G4	5036	broad.mit.edu	37	chr12	56498590	56498590	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcgtgaccaagtataagatGgggggcgacatcgccaacag	12	6	14	9	3	0	2	0	1	0	1	2	3	0	2	2	3	1	1	2	3	4	2	rs144476801		TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr12:56498590G>A	uc001sjm.2	+	1	488	c.69G>A	c.(67-69)ATG>ATA	p.M23I	PA2G4_uc009zol.2_Missense_Mutation_p.M23I|PA2G4_uc009zom.2_Missense_Mutation_p.M23I	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	23	Necessary for nucleolar localization.				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			AGTATAAGATGGGGGGCGACA	0.607													19	113					0	0	0	0	A	56498590	A	A	56498590	3	1	85	1	0	0	0	0	1	0	0	0	11415	1348	47	4	71	4	PA2G4	12	56498590	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	1142218	56498590	77353305	93	17051											
CUX2	23316	broad.mit.edu	37	chr12	111758419	111758419	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgcggctgccctactaccCggcctacgtgccgcgcaccc	4	5	11	21	7	0	0	0	0	0	0	0	0	0	0	5	2	5	2	5	2	3	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr12:111758419C>T	uc001tsa.1	+	17	2759	c.2606C>T	c.(2605-2607)CCG>CTG	p.P869L		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	869						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CCCTACTACCCGGCCTACGTG	0.726													5	2					0	0	0	0	T	111758419	T	T	111758419	3	4	85	1	0	0	0	0	1	0	0	0	4082	652	23	1	2672	1	CUX2	12	111758419	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	55259829	111758419	22093476	94	17052											
FRY	10129	broad.mit.edu	37	chr13	32729801	32729801	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaagccaaaatgataggTgagtttcagaagtgcataag	16	8	13	4	0	1	3	1	2	0	1	1	5	1	4	1	2	2	2	1	2	6	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr13:32729801T>A	uc001utx.2	+	15	2147	c.1651_splice	c.e15+2	p.G551_splice	FRY_uc010tdw.1_Splice_Site	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog						regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AAATGATAGGTGAGTTTCAGA	0.348													4	9					0	0	0	0	A	32729801	A	A	32729801	5	1	85	1	0	0	0	0	0	0	1	0	6097	1710	59	5	1711	5	FRY	13	32729801	Splice_Site	SNP	T	TCGA-CN-6994-01A-11D-1912-08		32729801	82440077	95	17053											
MED6	10001	broad.mit.edu	37	chr14	71067484	71067504	+	5'Flank	DEL	GGCAGGAGAGAGGCAGGGGGT	-	-																															gcggaagagggggcggggcgGgcaggagagaggcagggggt																										TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr14:71067484_71067504delGGCAGGAGAGAGGCAGGGGGT	uc001xmf.2	-						MED6_uc010tth.1_5'Flank|MED6_uc010tti.1_5'Flank|MED6_uc001xmg.1_5'Flank|MED6_uc010ttj.1_5'Flank	NM_005466	NP_005457	O75586	MED6_HUMAN	mediator of RNA polymerase II transcription,						positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	transcription coactivator activity				0				all cancers(60;0.00315)|BRCA - Breast invasive adenocarcinoma(234;0.00685)|OV - Ovarian serous cystadenocarcinoma(108;0.0352)		gggcggggcgggcaggagagaggcagggggtggaggtgcgg	0.167													---	---	---								-	71067504	-	-	71067484	6	5	85	0	1	1	0	1	0	0	0	0	9504	1247	43	0		0	MED6	14	71067484	5'Flank	DEL	GGCAGGAGAGAGGCAGGGGGT	TCGA-CN-6994-01A-11D-1912-08		71067484	36282056	96	17054											
TDP1	55775	broad.mit.edu	37	chr14	90509414	90509414	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaatgtgtttttcccccagAtcggccatggatatggaaca	10	12	10	9	1	0	1	0	0	0	1	2	3	1	3	3	3	1	2	3	3	3	4	rs148839664		TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr14:90509414A>G	uc001xxy.2	+	17	2053	c.1754A>G	c.(1753-1755)GAT>GGT	p.D585G	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.D585G|TDP1_uc010atn.2_3'UTR|TDP1_uc001xya.2_Missense_Mutation_p.D346G|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.I549V	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	585					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TTTCCCCCAGATCGGCCATGG	0.418								Repair_of_DNA-protein_crosslinks					11	129					0	0	0	0	G	90509414	G	G	90509414	3	3	85	1	0	0	0	0	1	0	0	0	15794	347	12	5	1812	5	TDP1	14	90509414	Missense_Mutation	SNP	A	TCGA-CN-6994-01A-11D-1912-08	19441930	90509414	16840126	97	17055											
BCL11B	64919	broad.mit.edu	37	chr14	99640654	99640654	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgcgtcttcatgtggcgcGtgagcttgctgctctgcgcg	2	12	15	12	6	3	1	1	1	2	0	3	1	3	1	0	1	5	3	0	1	0	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr14:99640654G>A	uc001yga.2	-	4	2786	c.2519C>T	c.(2518-2520)ACG>ATG	p.T840M	BCL11B_uc001ygb.2_Missense_Mutation_p.T769M	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	840	C2H2-type 5.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CATGTGGCGCGTGAGCTTGCT	0.622			T	TLX3	T-ALL								6	42					0	0	0	0	A	99640654	A	A	99640654	3	1	85	1	0	0	0	0	1	0	0	0	1366	1145	40	1	169	1	BCL11B	14	99640654	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	9131240	99640654	7708886	98	17056											
RAD51	5888	broad.mit.edu	37	chr15	41022163	41022163	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatatcatcgcccatgcatCaacaaccaggtaaggtgttg	14	9	8	10	1	2	0	2	0	0	0	3	0	2	0	2	2	3	3	2	2	5	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr15:41022163C>T	uc001zmi.3	+	9	1186	c.887C>T	c.(886-888)TCA>TTA	p.S296L	RAD51_uc010bbw.2_Intron|RAD51_uc010bbx.2_Missense_Mutation_p.S297L|RAD51_uc001zmk.3_RNA|RAD51_uc001zml.3_Missense_Mutation_p.S297L	NM_002875	NP_002866	Q06609	RAD51_HUMAN	RAD51 homolog protein isoform 1	296					DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity				0		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		GCCCATGCATCAACAACCAGG	0.408								Homologous_recombination					19	23					0	0	0	0	T	41022163	T	T	41022163	3	4	85	1	0	0	0	0	1	0	0	0	13050	838	29	2	1042	2	RAD51	15	41022163	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08		41022163	61509229	99	17057											
MYEF2	50804	broad.mit.edu	37	chr15	48441469	48441469	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgatgctcctttccagtataGctcctatacctggtcccatt	7	14	6	14	1	0	0	0	0	0	0	4	1	4	0	5	1	3	3	5	1	4	6			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr15:48441469G>C	uc001zwi.3	-	15	1602	c.1478C>G	c.(1477-1479)GCT>GGT	p.A493G	MYEF2_uc001zwg.3_Missense_Mutation_p.A31G|MYEF2_uc001zwh.3_Missense_Mutation_p.A81G|MYEF2_uc001zwj.3_Missense_Mutation_p.A469G	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	493	Gly-rich.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		TTCCAGTATAGCTCCTATACC	0.488													19	96					0	0	0	0	C	48441469	C	C	48441469	3	2	85	1	0	0	0	0	1	0	0	0	10077	971	34	4	336	4	MYEF2	15	48441469	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	7419306	48441469	54089923	100	17058											
IGDCC4	57722	broad.mit.edu	37	chr15	65703589	65703589	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caccctggtggggggtccagCggcagcagcccccaggctac	6	4	15	16	1	0	0	0	0	0	0	1	0	1	0	4	6	4	3	4	6	1	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr15:65703589C>T	uc002aou.1	-	2	400	c.190G>A	c.(190-192)GCT>ACT	p.A64T		NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	64	Ig-like C2-type 1.|Extracellular (Potential).|Poly-Ala.					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GGGGGTCCAGCGGCAGCAGCC	0.642													15	30					0	0	0	0	T	65703589	T	T	65703589	3	4	85	1	0	0	0	0	1	0	0	0	7608	768	27	1	3638	1	IGDCC4	15	65703589	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	17262120	65703589	36827803	101	17059											
TBC1D2B	23102	broad.mit.edu	37	chr15	78316600	78316600	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgccctcgccctcgctgagCttgatgatgacctcgtcctt	4	13	9	15	3	0	4	0	4	0	0	4	4	1	4	4	0	2	2	4	0	0	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr15:78316600C>A	uc002bcy.3	-	6	1368	c.1368G>T	c.(1366-1368)AAG>AAT	p.K456N	TBC1D2B_uc010bla.2_Missense_Mutation_p.K456N	NM_144572	NP_653173	Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B isoform a	456	Potential.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)|large_intestine(1)|breast(1)	3						CCTCGCTGAGCTTGATGATGA	0.617													19	45					5.3912e-06	6.91702e-06	1	0	A	78316600	A	A	78316600	3	1	85	1	0	0	0	0	1	0	0	0	15685	796	28	4	1555	4	TBC1D2B	15	78316600	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	12613011	78316600	24214792	102	17060											
IREB2	3658	broad.mit.edu	37	chr15	78758639	78758639	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acagaatgcaccaaatcctgGaggtggtgacctgcagaaag	14	6	12	9	0	0	3	0	1	0	2	1	4	1	4	3	3	2	2	3	3	3	0			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr15:78758639G>C	uc002bdr.2	+	5	599	c.437G>C	c.(436-438)GGA>GCA	p.G146A	IREB2_uc010unb.1_5'UTR|IREB2_uc002bdq.2_Missense_Mutation_p.G146A	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	146							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		CCAAATCCTGGAGGTGGTGAC	0.433													4	35					0	0	0	0	C	78758639	C	C	78758639	3	2	85	1	0	0	0	0	1	0	0	0	7865	1174	41	2	455	2	IREB2	15	78758639	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	442039	78758639	23772753	103	17061											
RHOT2	89941	broad.mit.edu	37	chr16	723125	723125	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcgccaccatggccgcCttcccgtgggtacccagtag	6	7	11	17	3	0	0	0	0	0	0	2	0	1	0	6	2	2	3	6	2	2	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr16:723125C>T	uc002cip.2	+	18	1792	c.1725C>T	c.(1723-1725)GCC>GCT	p.A575A	RHOT2_uc002ciq.2_Silent_p.A468A|RHOT2_uc010bqy.2_Silent_p.A354A|RHBDL1_uc002cir.1_5'Flank|RHBDL1_uc010uun.1_5'Flank|RHBDL1_uc002cis.1_5'Flank	NM_138769	NP_620124	Q8IXI1	MIRO2_HUMAN	ras homolog gene family, member T2	575	Miro 2.|Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			pancreas(1)	1		Hepatocellular(780;0.0218)				CCATGGCCGCCTTCCCGTGGG	0.667													6	24					0	0	0	0	T	723125	T	T	723125	2	4	85	1	0	0	0	0	0	0	0	1	13409	668	24	4		4	RHOT2	16	723125	Silent	SNP	C	TCGA-CN-6994-01A-11D-1912-08		723125	89631628	104	17062											
TSC2	7249	broad.mit.edu	37	chr16	2134999	2134999	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccttctttggcgacgagtCaaacaagccaatcctgctgc	9	9	8	15	2	2	0	1	0	1	0	3	2	3	0	4	1	4	1	4	1	3	2	rs137854193		TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr16:2134999C>G	uc002con.2	+	35	4647	c.4541C>G	c.(4540-4542)TCA>TGA	p.S1514*	TSC2_uc010bsd.2_Nonsense_Mutation_p.S1491*|TSC2_uc002coo.2_Nonsense_Mutation_p.S1447*|TSC2_uc010uvv.1_Nonsense_Mutation_p.S1411*|TSC2_uc010uvw.1_Nonsense_Mutation_p.S1399*|TSC2_uc002cop.2_Nonsense_Mutation_p.S1270*|TSC2_uc002coq.2_Nonsense_Mutation_p.S289*|TSC2_uc002cor.2_Nonsense_Mutation_p.S215*	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1514					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				GGCGACGAGTCAAACAAGCCA	0.637			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				3	40					0	0	0	0	G	2134999	G	G	2134999	4	3	85	1	0	0	0	0	0	1	0	0	16673	838	29	2	4675	2	TSC2	16	2134999	Nonsense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	1411874	2134999	88219754	105	17063											
NLRC3	197358	broad.mit.edu	37	chr16	3614104	3614104	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccgtcatccggtccaccagGccccctgggatctggccaga	6	7	11	17	2	2	1	1	0	1	1	5	2	5	2	7	4	0	0	7	4	0	0			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr16:3614104G>A	uc010btn.2	-	5	1245	c.834C>T	c.(832-834)GGC>GGT	p.G278G		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	278	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GGTCCACCAGGCCCCCTGGGA	0.592													18	34					0	0	0	0	A	3614104	A	A	3614104	2	1	85	1	0	0	0	0	0	0	0	1	10522	1190	42	4		4	NLRC3	16	3614104	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	1479105	3614104	86740649	106	17064											
PRR14	78994	broad.mit.edu	37	chr16	30665627	30665627	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccattccagccatctgctCtgcctgcagaccctctggag	6	9	8	18	0	3	1	0	0	3	1	4	2	4	2	6	1	4	2	6	1	0	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr16:30665627C>G	uc002dyy.2	+	7	883	c.625C>G	c.(625-627)CTG>GTG	p.L209V	PRR14_uc002dyz.2_Missense_Mutation_p.L54V|PRR14_uc002dza.2_Missense_Mutation_p.L209V|PRR14_uc002dzb.1_Missense_Mutation_p.L23V	NM_024031	NP_076936	Q9BWN1	PRR14_HUMAN	proline rich 14	209	Pro-rich.										0			Colorectal(24;0.103)			GCCATCTGCTCTGCCTGCAGA	0.577													4	182					0	0	0	0	G	30665627	G	G	30665627	3	3	85	1	0	0	0	0	1	0	0	0	12648	912	32	2	647	2	PRR14	16	30665627	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	27051523	30665627	59689126	107	17065											
CTU2	348180	broad.mit.edu	37	chr16	88776402	88776402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccatgctgggcaagaaccGgctcatctttccaggcgaga	10	7	12	12	2	2	2	1	0	1	2	3	3	3	2	3	3	3	3	3	3	2	1	rs149997219	byFrequency	TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr16:88776402G>A	uc002flm.2	+	3	248	c.200G>A	c.(199-201)CGG>CAG	p.R67Q	CTU2_uc002fln.2_Missense_Mutation_p.R67Q|CTU2_uc010chz.2_Missense_Mutation_p.R67Q|CTU2_uc010cia.2_Intron	NM_001012759	NP_001012777	Q2VPK5	CTU2_HUMAN	cytoplasmic tRNA 2-thiolation protein 2 isoform	67					tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			skin(1)	1						GGCAAGAACCGGCTCATCTTT	0.612													42	68					0	0	0	0	A	88776402	A	A	88776402	3	1	85	1	0	0	0	0	1	0	0	0	4065	1116	39	1	210	1	CTU2	16	88776402	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	58110775	88776402	1578351	108	17066											
OR1D2	4991	broad.mit.edu	37	chr17	2996352	2996352	+	5'Flank	DEL	A	-	-																															ccaaaagtccttaattgaatAaaaacatgaagataagcaaa																										TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:2996352delA	uc010vrb.1	-							NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,						cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						TTAATTGAATAAAAACATGAA	0.299													---	---	---								-	2996352	-	-	2996352	6	5	85	0	1	1	0	1	0	0	0	0	11007	377	13	0		0	OR1D2	17	2996352	5'Flank	DEL	A	TCGA-CN-6994-01A-11D-1912-08		2996352	78198858	109	17067											
TP53	7157	broad.mit.edu	37	chr17	7577090	7577090	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagattctcttcctctgtgCgccggtctctcccaggacag	5	11	11	14	2	3	1	0	0	3	1	7	3	5	2	3	3	1	0	3	3	0	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:7577090C>G	uc002gim.2	-	8	1042	c.848G>C	c.(847-849)CGC>CCC	p.R283P	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R283P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R151P|TP53_uc010cng.1_Missense_Mutation_p.R151P|TP53_uc002gii.1_Missense_Mutation_p.R151P|TP53_uc010cnh.1_Missense_Mutation_p.R283P|TP53_uc010cni.1_Missense_Mutation_p.R283P|TP53_uc002gij.2_Missense_Mutation_p.R283P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	283	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> H (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R283P(23)|p.R283C(18)|p.R283H(12)|p.0?(7)|p.R283L(4)|p.R283R(4)|p.R283fs*62(4)|p.R283G(2)|p.R283fs*63(2)|p.?(2)|p.R283fs*16(2)|p.A276_R283delACPGRDRR(1)|p.R283del(1)|p.R283S(1)|p.R283fs*22(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCCTCTGTGCGCCGGTCTCT	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	40					0	0	0	0	G	7577090	G	G	7577090	3	3	85	1	0	0	0	0	1	0	0	0	16448	768	27	3	438	3	TP53	17	7577090	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	4580738	7577090	73618120	110	17068											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	7	7	13	14	3	3	0	3	0	0	0	4	0	4	0	3	3	3	2	3	3	1	0	rs28934578		TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	48					0	0	0	0	T	7578406	T	T	7578406	3	4	85	1	0	0	0	0	1	0	0	0	16448	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	1316	7578406	73616804	111	17069											
NOS2	4843	broad.mit.edu	37	chr17	26089930	26089930	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcttcagaatggggagctgGgaaagcaggaagccagcaga	13	4	17	7	0	1	2	1	0	0	2	1	5	1	5	1	5	4	4	1	5	3	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:26089930G>A	uc002gzu.2	-	22	2958	c.2694C>T	c.(2692-2694)TCC>TCT	p.S898S		NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	898	FAD-binding FR-type.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TGGGGAGCTGGGAAAGCAGGA	0.592													5	5					0	0	0	0	A	26089930	A	A	26089930	2	1	85	1	0	0	0	0	0	0	0	1	10597	1219	43	4		4	NOS2	17	26089930	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	18511524	26089930	55105280	112	17070											
EFCAB5	374786	broad.mit.edu	37	chr17	28407106	28407106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtaggatgctgaagcccatgGaaataaaaagatcagtgctc	15	8	11	7	0	1	2	1	1	0	1	2	4	1	4	1	2	3	3	1	2	6	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:28407106G>A	uc002het.2	+	16	3236	c.3044G>A	c.(3043-3045)GGA>GAA	p.G1015E	EFCAB5_uc010cse.2_Missense_Mutation_p.G770E|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1015							calcium ion binding			ovary(1)|skin(1)	2						GAAGCCCATGGAAATAAAAAG	0.428													16	94					0	0	0	0	A	28407106	A	A	28407106	3	1	85	1	0	0	0	0	1	0	0	0	4960	1174	41	2	3273	2	EFCAB5	17	28407106	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	2317176	28407106	52788104	113	17071											
SUZ12	23512	broad.mit.edu	37	chr17	30302527	30302527	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgtccaataaggcaagtTcccacaggtaaaaagcaggt	15	8	10	8	0	0	0	0	0	0	0	2	0	2	0	2	3	1	5	2	3	6	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:30302527T>C	uc002hgs.2	+	7	840	c.618T>C	c.(616-618)GTT>GTC	p.V206V	SUZ12_uc002hgt.2_Silent_p.V183V	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	206					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				TAAGGCAAGTTCCCACAGGTA	0.328			T	JAZF1	endometrial stromal tumours								22	35					0	0	0	0	C	30302527	C	C	30302527	2	2	85	1	0	0	0	0	0	0	0	1	15482	1770	62	5		5	SUZ12	17	30302527	Silent	SNP	T	TCGA-CN-6994-01A-11D-1912-08	1895421	30302527	50892683	114	17072											
OSBPL7	114881	broad.mit.edu	37	chr17	45890757	45890757	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaggccgagacagcaaaggCtgcgatgtacacctgtgggg	10	6	16	9	2	0	1	0	0	0	1	0	3	0	1	2	4	3	4	2	4	3	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:45890757C>T	uc002ilx.1	-	16	1815	c.1612G>A	c.(1612-1614)GCC>ACC	p.A538T	OSBPL7_uc002ilw.1_Missense_Mutation_p.A100T	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	538					lipid transport		lipid binding				0						ACAGCAAAGGCTGCGATGTAC	0.622													15	28					0	0	0	0	T	45890757	T	T	45890757	3	4	85	1	0	0	0	0	1	0	0	0	11336	797	28	4	948	4	OSBPL7	17	45890757	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	15588230	45890757	35304453	115	17073											
CSHL1	1444	broad.mit.edu	37	chr17	61988275	61988275	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaagccaggagcagggacGtccgggagcctggggagaaa	13	2	17	9	2	0	1	0	0	0	1	1	5	1	4	3	5	3	1	3	5	3	0			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:61988275G>T	uc002jda.1	-	2	82	c.20C>A	c.(19-21)ACG>AAG	p.T7K	CSHL1_uc002jcz.1_Missense_Mutation_p.T7K|CSHL1_uc002jdb.1_Intron|CSHL1_uc002jdc.1_Intron|CSHL1_uc002jdd.1_Missense_Mutation_p.T7K|CSHL1_uc002jde.2_Missense_Mutation_p.T35K|CSHL1_uc002jdf.2_Intron|CSHL1_uc002jdg.2_Missense_Mutation_p.T7K|CSHL1_uc002jdh.2_Intron	NM_022579	NP_072101	Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	7						extracellular region	hormone activity|metal ion binding				0						GAGCAGGGACGTCCGGGAGCC	0.582													12	38					9.05144e-12	1.231e-11	1	0	T	61988275	T	T	61988275	3	4	85	1	0	0	0	0	1	0	0	0	3959	1145	40	3	664	3	CSHL1	17	61988275	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	16097518	61988275	19206935	116	17074											
SCN4A	6329	broad.mit.edu	37	chr17	62029168	62029168	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgatgcgcccgatggcaatCtgcaggttgttcatctcgcc	6	12	11	12	3	3	1	1	1	2	0	4	2	3	1	2	2	2	4	2	2	1	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:62029168C>G	uc002jds.1	-	14	2546	c.2469G>C	c.(2467-2469)CAG>CAC	p.Q823H		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	823					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	CGATGGCAATCTGCAGGTTGT	0.602													3	6					0	0	0	0	G	62029168	G	G	62029168	3	3	85	1	0	0	0	0	1	0	0	0	13985	912	32	2	3085	2	SCN4A	17	62029168	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	40893	62029168	19166042	117	17075											
HELZ	9931	broad.mit.edu	37	chr17	65105354	65105354	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtggccttcttgcagcatgGgagggggctgctgctccgga	4	10	17	10	1	1	0	0	0	1	0	2	2	2	2	2	5	4	5	2	5	0	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:65105354G>T	uc010wqk.1	-	29	4557	c.4370C>A	c.(4369-4371)CCC>CAC	p.P1457H	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.P1456H|HELZ_uc010der.2_5'UTR	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TTGCAGCATGGGAGGGGGCTG	0.532													17	70					2.23348e-06	2.88374e-06	1	0	T	65105354	T	T	65105354	3	4	85	1	0	0	0	0	1	0	0	0	7088	1232	43	4	1481	4	HELZ	17	65105354	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	3076186	65105354	16089856	118	17076											
GALR2	8811	broad.mit.edu	37	chr17	74073206	74073206	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctcctacgccaactcctgCgtcaaccccatcgtttacgc	7	10	6	18	4	2	0	1	0	1	0	5	0	3	0	5	0	5	1	5	0	4	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:74073206C>A	uc002jqm.1	+	2	939	c.858C>A	c.(856-858)TGC>TGA	p.C286*	ZACN_uc002jqn.2_5'Flank|ZACN_uc002jqo.2_5'Flank|ZACN_uc010dgu.2_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	286	Cytoplasmic (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						CCAACTCCTGCGTCAACCCCA	0.662													4	24					0.00024832	0.000310781	1	0	A	74073206	A	A	74073206	4	1	85	1	0	0	0	0	0	1	0	0	6263	776	27	3	864	3	GALR2	17	74073206	Nonsense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	8967852	74073206	7122004	119	17077											
TNRC6C	57690	broad.mit.edu	37	chr17	76046391	76046391	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcactgggagggaaggaacGggagaaggccgaaggcgaga	14	1	20	6	3	0	2	0	0	0	2	0	8	0	5	1	6	2	1	1	6	4	0			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:76046391G>A	uc002jud.2	+	4	1848	c.1248G>A	c.(1246-1248)ACG>ACA	p.T416T	TNRC6C_uc002juf.2_Silent_p.T416T|TNRC6C_uc002jue.2_Silent_p.T416T	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	416	Sufficient for interaction with argonaute family proteins.|Gly-rich.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GGGAAGGAACGGGAGAAGGCC	0.507													29	74					0	0	0	0	A	76046391	A	A	76046391	2	1	85	1	0	0	0	0	0	0	0	1	16408	1103	39	1		1	TNRC6C	17	76046391	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	1973185	76046391	5148819	120	17078											
DNAH17	8632	broad.mit.edu	37	chr17	76471394	76471407	+	5'Flank	DEL	GTGATCTGAAACAC	-	-																															tcccgtagcccttcttgaggGtgatctgaaacacgtcaagc																								rs5822243		TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:76471394_76471407delGTGATCTGAAACAC	uc002jvs.2	-											Homo sapiens mRNA for DNAH17 variant protein, partial cds.											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CTTCTTGAGGGTGATCTGAAACACGTCAAGCCCG	0.584													---	---	---								-	76471407	-	-	76471394	6	5	85	0	1	1	0	1	0	0	0	0	4623	1261	44	0		0	DNAH17	17	76471394	5'Flank	DEL	GTGATCTGAAACAC	TCGA-CN-6994-01A-11D-1912-08	425003	76471394	4723816	121	17079											
RNF213	57674	broad.mit.edu	37	chr17	78337076	78337076	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggttctccacagcctgatgGaagcccgttggaaccatgag	10	8	12	11	1	1	2	0	2	1	0	2	4	1	4	4	3	3	2	4	3	2	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr17:78337076G>A	uc002jyh.1	+	15	5972	c.5749G>A	c.(5749-5751)GAA>AAA	p.E1917K	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.E299K	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CAGCCTGATGGAAGCCCGTTG	0.567													18	87					0	0	0	0	A	78337076	A	A	78337076	3	1	85	1	0	0	0	0	1	0	0	0	13542	1175	41	2	12003	2	RNF213	17	78337076	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	1865682	78337076	2858134	122	17080											
ONECUT2	9480	broad.mit.edu	37	chr18	55103824	55103824	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggccatgatgtcgcacctGaacggcctgcaccacccggg	7	5	13	16	4	0	2	0	2	0	0	1	2	0	2	5	3	2	2	5	3	1	0			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr18:55103824G>C	uc002lgo.2	+	1	908	c.876G>C	c.(874-876)CTG>CTC	p.L292L		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	292					organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		TGTCGCACCTGAACGGCCTGC	0.706													7	41					0	0	0	0	C	55103824	C	C	55103824	2	2	85	1	0	0	0	0	0	0	0	1	10923	1277	45	2		2	ONECUT2	18	55103824	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08		55103824	22973424	123	17081											
SOCS6	9306	broad.mit.edu	37	chr18	67993288	67993288	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgatctaattgagcattcaAtcagggactctgaaaatgga	14	12	9	6	0	4	3	2	3	2	0	4	5	4	5	0	2	1	1	0	2	4	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr18:67993288A>G	uc002lkr.1	+	2	1700	c.1384A>G	c.(1384-1386)ATC>GTC	p.I462V	SOCS6_uc010dqq.2_Missense_Mutation_p.I462V	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	462	SH2.				defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				TGAGCATTCAATCAGGGACTC	0.448													7	41					0	0	0	0	G	67993288	G	G	67993288	3	3	85	1	0	0	0	0	1	0	0	0	14982	101	4	5	1386	5	SOCS6	18	67993288	Missense_Mutation	SNP	A	TCGA-CN-6994-01A-11D-1912-08	12889464	67993288	10083960	124	17082											
BTBD2	55643	broad.mit.edu	37	chr19	1993166	1993166	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaatctgcacctcgtccgaGtagagaaacctgcagaagca	13	6	9	13	2	1	2	0	0	1	2	3	4	2	2	4	0	4	4	4	0	4	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:1993166G>C	uc002lup.1	-	3	537	c.537C>G	c.(535-537)TAC>TAG	p.Y179*	BTBD2_uc002luo.1_5'Flank	NM_017797	NP_060267	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	179	BTB.					cytoplasmic mRNA processing body	protein binding			ovary(1)|skin(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCGTCCGAGTAGAGAAACC	0.647													5	24					0	0	0	0	C	1993166	C	C	1993166	4	2	85	1	0	0	0	0	0	1	0	0	1548	1024	36	4	1068	4	BTBD2	19	1993166	Nonsense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08		1993166	57135817	125	17083											
ZNF846	162993	broad.mit.edu	37	chr19	9869059	9869059	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaattactgaaggctttccCacattccttacatacatagt	12	13	6	10	0	0	1	0	1	0	0	2	2	2	2	2	2	3	1	2	2	6	6			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:9869059C>T	uc002mmb.1	-	6	1225	c.694G>A	c.(694-696)GGG>AGG	p.G232R	ZNF846_uc010xky.1_RNA|ZNF846_uc010xkz.1_RNA|ZNF846_uc010dww.2_Missense_Mutation_p.G103R|ZNF846_uc002mmc.1_Missense_Mutation_p.G103R	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	232	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAGGCTTTCCCACATTCCTTA	0.383													14	40					0	0	0	0	T	9869059	T	T	9869059	3	4	85	1	0	0	0	0	1	0	0	0	18259	594	21	4	911	4	ZNF846	19	9869059	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	7875893	9869059	49259924	126	17084											
FBXL12	54850	broad.mit.edu	37	chr19	9931194	9931194	+	5'Flank	DEL	A	-	-																															ataaattctacttcctgtccAaaaaaaaaaatgtgtgtgtg																										TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:9931194delA	uc002mme.2	-						FBXL12_uc002mmd.2_5'Flank|FBXL12_uc002mmf.2_5'Flank|FBXL12_uc002mmg.2_5'Flank|FBXL12_uc002mmh.2_Intron	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12								protein binding			lung(1)|kidney(1)	2						CTTCCTGTCCAAAAAAAAAAA	0.338													---	---	---								-	9931194	-	-	9931194	6	5	85	0	1	1	0	1	0	0	0	0	5740	145	5	0		0	FBXL12	19	9931194	5'Flank	DEL	A	TCGA-CN-6994-01A-11D-1912-08	62135	9931194	49197789	127	17085											
KRI1	65095	broad.mit.edu	37	chr19	10665783	10665783	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttctcggcagagtgacttGaagacctgccgctttttcca	7	13	9	12	2	2	4	0	2	2	2	4	4	3	4	3	1	1	2	3	1	1	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:10665783G>C	uc002moy.1	-	18	1788	c.1779C>G	c.(1777-1779)TTC>TTG	p.F593L	KRI1_uc002mow.1_Missense_Mutation_p.F212L|KRI1_uc002mox.1_Missense_Mutation_p.F589L	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	593										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			AGAGTGACTTGAAGACCTGCC	0.343													8	43					0	0	0	0	C	10665783	C	C	10665783	3	2	85	1	0	0	0	0	1	0	0	0	8483	1281	45	2	358	2	KRI1	19	10665783	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	734589	10665783	48463200	128	17086											
ZNF791	163049	broad.mit.edu	37	chr19	12739064	12739064	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgaaagaactcacactggaGagaaaccctatgcatgtaag	17	6	9	9	1	1	2	1	0	0	2	1	5	1	3	1	1	3	2	1	1	5	2			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:12739064G>A	uc002mua.2	+	4	883	c.721G>A	c.(721-723)GAG>AAG	p.E241K	ZNF791_uc010xml.1_Missense_Mutation_p.E209K|ZNF791_uc010dyu.1_Missense_Mutation_p.E132K|ZNF791_uc010xmm.1_Missense_Mutation_p.E132K	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	241					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TCACACTGGAGAGAAACCCTA	0.413													4	38					0	0	0	0	A	12739064	A	A	12739064	3	1	85	1	0	0	0	0	1	0	0	0	18230	943	33	2	735	2	ZNF791	19	12739064	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	2073281	12739064	46389919	129	17087											
KCNN1	3780	broad.mit.edu	37	chr19	18084972	18084972	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accctcaaatgtgggccaccGcctgggccaccggcgggcgc	6	4	14	17	4	1	0	1	0	0	0	1	0	1	0	6	4	0	0	6	4	1	0			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:18084972G>A	uc002nht.2	+	3	585	c.275G>A	c.(274-276)CGC>CAC	p.R92H	KCNN1_uc010xqa.1_Missense_Mutation_p.R92H	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	92					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						GTGGGCCACCGCCTGGGCCAC	0.647													17	9					0	0	0	0	A	18084972	A	A	18084972	3	1	85	1	0	0	0	0	1	0	0	0	8117	1087	38	1	277	1	KCNN1	19	18084972	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	5345908	18084972	41044011	130	17088											
ARMC6	93436	broad.mit.edu	37	chr19	19153573	19153573	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aacacaggcgaagatggtctCcaagcgcattgcccaggaga	13	5	12	11	2	1	2	0	0	1	2	2	4	1	2	2	3	3	1	2	3	3	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:19153573C>T	uc002nld.2	+	3	431	c.83C>T	c.(82-84)TCC>TTC	p.S28F	ARMC6_uc002nlc.2_Missense_Mutation_p.S3F|ARMC6_uc010xql.1_Intron|ARMC6_uc002nle.2_Missense_Mutation_p.S3F|ARMC6_uc010xqm.1_Missense_Mutation_p.S28F	NM_033415	NP_219483	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	28							protein binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			AAGATGGTCTCCAAGCGCATT	0.577													7	45					0	0	0	0	T	19153573	T	T	19153573	3	4	85	1	0	0	0	0	1	0	0	0	957	855	30	2	10	2	ARMC6	19	19153573	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	1068601	19153573	39975410	131	17089											
ZNF737	100129842	broad.mit.edu	37	chr19	20728196	20728196	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	attatcttatgtgtagtaagGttagaggagcgcttaaaggc	12	13	12	4	1	1	1	0	0	1	1	1	2	1	2	0	3	1	4	0	3	7	6			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:20728196G>A	uc002npa.2	-	4	993	c.813C>T	c.(811-813)AAC>AAT	p.N271N		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	271					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GTGTAGTAAGGTTAGAGGAGC	0.413													3	25					0	0	0	0	A	20728196	A	A	20728196	2	1	85	1	0	0	0	0	0	0	0	1	18193	1252	44	4		4	ZNF737	19	20728196	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	1574623	20728196	38400787	132	17090											
ZBTB32	27033	broad.mit.edu	37	chr19	36205889	36205889	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggacagggctaaaaagccaGatccaggcctgaagaaacat	16	4	12	9	0	0	3	0	1	0	2	1	4	1	4	3	3	2	1	3	3	5	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:36205889G>A	uc002oay.2	+	2	571	c.361G>A	c.(361-363)GAT>AAT	p.D121N	ZBTB32_uc002oaz.2_RNA	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	121					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TAAAAAGCCAGATCCAGGCCT	0.587													182	322					0	0	0	0	A	36205889	A	A	36205889	3	1	85	1	0	0	0	0	1	0	0	0	17602	942	33	2	363	2	ZBTB32	19	36205889	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	15477693	36205889	22923094	133	17091											
ZNF567	163081	broad.mit.edu	37	chr19	37210699	37210699	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctcattcgtcatcagagaaCtcacacgggagagaaaccat	14	7	8	12	2	4	2	4	0	0	2	5	5	4	3	2	1	2	0	2	1	2	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:37210699C>A	uc010xtl.1	+	6	1295	c.1073C>A	c.(1072-1074)ACT>AAT	p.T358N	ZNF567_uc002oeo.1_Missense_Mutation_p.T358N|ZNF567_uc010xtk.1_Missense_Mutation_p.T358N|ZNF567_uc002oep.3_Missense_Mutation_p.T327N|ZNF567_uc002oeq.1_Missense_Mutation_p.T327N	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	358	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CATCAGAGAACTCACACGGGA	0.448													9	37					3.09899e-07	4.02671e-07	1	0	A	37210699	A	A	37210699	3	1	85	1	0	0	0	0	1	0	0	0	18065	565	20	4	990	4	ZNF567	19	37210699	Missense_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	1004810	37210699	21918284	134	17092											
ZNF420	147923	broad.mit.edu	37	chr19	37619879	37619879	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacagctaactcaacatcaGagaattcatatcagtgagaa	17	9	6	9	0	5	2	5	1	0	2	5	4	5	2	0	0	3	1	0	0	5	3			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:37619879G>C	uc002ofl.2	+	5	2201	c.1986G>C	c.(1984-1986)CAG>CAC	p.Q662H		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	662	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTCAACATCAGAGAATTCATA	0.373													7	54					0	0	0	0	C	37619879	C	C	37619879	3	2	85	1	0	0	0	0	1	0	0	0	17964	933	33	2	1996	2	ZNF420	19	37619879	Missense_Mutation	SNP	G	TCGA-CN-6994-01A-11D-1912-08	409180	37619879	21509104	135	17093											
RASIP1	54922	broad.mit.edu	37	chr19	49224214	49224214	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgcgagctccccagggggagGatgaggggcgggtgcgagga	7	3	22	9	4	0	1	0	1	0	0	1	6	1	4	2	7	2	1	2	7	0	0			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:49224214G>A	uc002pki.2	-	12	2930	c.2733C>T	c.(2731-2733)ATC>ATT	p.I911I	MAMSTR_uc002pkg.2_5'Flank|RASIP1_uc002pkh.2_Silent_p.I172I	NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	911					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		CCAGGGGGAGGATGAGGGGCG	0.642													7	29					0	0	0	0	A	49224214	A	A	49224214	2	1	85	1	0	0	0	0	0	0	0	1	13143	1164	41	2		2	RASIP1	19	49224214	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	11604335	49224214	9904769	136	17094											
ZNF766	90321	broad.mit.edu	37	chr19	52794352	52794352	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagaatccacactggagaGaaaccttacaaatgccatgt	16	7	8	10	0	0	2	0	0	0	2	1	5	1	3	3	1	3	0	3	1	4	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:52794352G>A	uc002pyr.1	+	4	1351	c.1308G>A	c.(1306-1308)GAG>GAA	p.E436E	ZNF766_uc002pys.1_3'UTR|ZNF766_uc002pyt.1_Silent_p.E451E	NM_001010851	NP_001010851	Q5HY98	ZN766_HUMAN	zinc finger protein 766	436					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		ACACTGGAGAGAAACCTTACA	0.413													8	103					0	0	0	0	A	52794352	A	A	52794352	2	1	85	1	0	0	0	0	0	0	0	1	18207	933	33	2		2	ZNF766	19	52794352	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08	3570138	52794352	6334631	137	17095											
C19orf51	352909	broad.mit.edu	37	chr19	55670431	55670431	+	Nonstop_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggtgtctaggggttgggtCagactccagttttggagtct	5	13	17	6	0	3	1	1	0	2	1	4	2	4	2	1	6	0	2	1	6	1	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr19:55670431C>G	uc002qji.1	-	12	1659	c.1625G>C	c.(1624-1626)TGA>TCA	p.*542S	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Nonstop_Mutation_p.*357S|C19orf51_uc002qjj.1_Nonstop_Mutation_p.*589S|C19orf51_uc002qjk.1_Nonstop_Mutation_p.*488S|C19orf51_uc002qjl.1_Nonstop_Mutation_p.*609S			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	542											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GGGGTTGGGTCAGACTCCAGT	0.542													6	34					0	0	0	0	G	55670431	G	G	55670431	4	3	85	1	0	0	0	0	0	0	0	0	1942	837	29	2	4	2	C19orf51	19	55670431	Nonstop_Mutation	SNP	C	TCGA-CN-6994-01A-11D-1912-08	2876079	55670431	3458552	138	17096											
CEP250	11190	broad.mit.edu	37	chr20	34091852	34091852	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggacggcgggtccaggccctGgaggaggtgctgggagacct	6	5	20	10	2	0	1	0	0	0	1	1	5	1	4	3	8	1	1	3	8	0	0			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr20:34091852G>A	uc002xcm.2	+	31	6326	c.5655G>A	c.(5653-5655)CTG>CTA	p.L1885L	CEP250_uc010zve.1_Silent_p.L1253L	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1885	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TCCAGGCCCTGGAGGAGGTGC	0.617													12	31					0	0	0	0	A	34091852	A	A	34091852	2	1	85	1	0	0	0	0	0	0	0	1	3267	1335	47	4		4	CEP250	20	34091852	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08		34091852	28933668	139	17097											
KCNJ15	3772	broad.mit.edu	37	chr21	39671654	39671654	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcatcacgaccttgattgaGatcttcatcaccggaacctt	10	12	7	12	2	5	2	4	2	1	1	5	5	5	3	3	1	1	0	3	1	1	4			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr21:39671654G>A	uc002ywv.2	+	4	773	c.471G>A	c.(469-471)GAG>GAA	p.E157E	KCNJ15_uc002yww.2_Silent_p.E157E|KCNJ15_uc002ywx.2_Silent_p.E157E	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	157	Helical; Name=M2; (By similarity).	Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium (By similarity).			synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						CCTTGATTGAGATCTTCATCA	0.512													9	47					0	0	0	0	A	39671654	A	A	39671654	2	1	85	1	0	0	0	0	0	0	0	1	8088	933	33	2		2	KCNJ15	21	39671654	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08		39671654	8458241	140	17098											
L3MBTL2	83746	broad.mit.edu	37	chr22	41623845	41623845	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggccaaagaggccacaaaGaagaaaaagaaacagtttgg	21	3	11	6	0	0	4	0	0	0	4	0	4	0	4	2	3	1	1	2	3	7	1			TCGA-CN-6994-01A-11D-1912-08	TCGA-CN-6994-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	157b67ad-f092-4ea3-b557-0406839e6905	ecbf546c-60d0-433c-940b-68f82af90250	g.chr22:41623845G>A	uc003azo.2	+	15	1914	c.1860G>A	c.(1858-1860)AAG>AAA	p.K620K	L3MBTL2_uc010gyi.1_3'UTR|L3MBTL2_uc003azn.2_RNA	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	620	Poly-Lys.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						AGGCCACAAAGAAGAAAAAGA	0.572													6	36					0	0	0	0	A	41623845	A	A	41623845	2	1	85	1	0	0	0	0	0	0	0	1	8632	933	33	2		2	L3MBTL2	22	41623845	Silent	SNP	G	TCGA-CN-6994-01A-11D-1912-08		41623845	9680721	141	17099											
EYA3	2140	broad.mit.edu	37	chr1	28384547	28384547	+	Translation_Start_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttcttccatgaggaccaaTatttctttattatacttatg	10	19	4	8	0	3	1	0	1	3	0	4	2	4	2	2	1	1	0	2	1	6	9			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:28384547T>C	uc001bpi.1	-	2	156	c.-9A>G	c.(-11--7)ATATT>ATGTT		EYA3_uc010ofs.1_Translation_Start_Site|EYA3_uc010oft.1_Translation_Start_Site|EYA3_uc001bpj.2_Translation_Start_Site|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3						anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		TGAGGACCAATATTTCTTTAT	0.328													45	31					0	0	0	0	C	28384547	C	C	28384547	1	2	86	1	0	0	0	0	0	0	0	0	5355	1421	49	5		5	EYA3	1	28384547	Translation_Start_Site	SNP	T	TCGA-CN-6995-01A-31D-2012-08		28384547	220866074	1	17100											
DOCK7	85440	broad.mit.edu	37	chr1	62943474	62943474	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttccataaaaaccaacaCgaaaataggtgccaaacatc	18	7	6	10	1	0	0	0	0	0	0	2	1	1	0	3	2	4	1	3	2	8	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:62943474C>A	uc001daq.2	-	43	5532	c.5498G>T	c.(5497-5499)CGT>CTT	p.R1833L	DOCK7_uc001dan.2_Missense_Mutation_p.R1696L|DOCK7_uc001dao.2_Missense_Mutation_p.R1694L|DOCK7_uc001dap.2_Missense_Mutation_p.R1813L|DOCK7_uc001dam.2_Missense_Mutation_p.R1015L|DOCK7_uc010oov.1_Missense_Mutation_p.R574L|DOCK7_uc001dar.1_Missense_Mutation_p.R7L	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1844	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AAAACCAACACGAAAATAGGT	0.363													30	44					1.71298e-08	2.06351e-08	1	0	A	62943474	A	A	62943474	3	1	86	1	0	0	0	0	1	0	0	0	4714	536	19	3	919	3	DOCK7	1	62943474	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	34558927	62943474	186307147	2	17101											
LPAR3	23566	broad.mit.edu	37	chr1	85331581	85331581	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattccagcgaagaaatcggCagcagctaaattagccaaca	17	6	8	10	2	0	1	0	0	0	1	2	2	1	1	2	1	5	3	2	1	7	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:85331581C>T	uc001dkl.2	-	1	262	c.223G>A	c.(223-225)GCC>ACC	p.A75T	LPAR3_uc009wcj.1_Missense_Mutation_p.A75T	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	75	Helical; Name=2; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						AAGAAATCGGCAGCAGCTAAA	0.423													22	108					0	0	0	0	T	85331581	T	T	85331581	3	4	86	1	0	0	0	0	1	0	0	0	8956	710	25	4	846	4	LPAR3	1	85331581	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	22388107	85331581	163919040	3	17102											
BARHL2	343472	broad.mit.edu	37	chr1	91180103	91180103	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacctgcggttctggtacCaggtcttgacttgggtgtca	5	14	12	10	1	3	1	1	1	2	0	3	1	3	1	2	4	3	2	2	4	2	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:91180103C>T	uc001dns.2	-	2	878	c.836G>A	c.(835-837)TGG>TAG	p.W279*		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	279	Homeobox.					nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		GTTCTGGTACCAGGTCTTGAC	0.547													43	52					0	0	0	0	T	91180103	T	T	91180103	4	4	86	1	0	0	0	0	0	1	0	0	1316	595	21	4	335	4	BARHL2	1	91180103	Nonsense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	5848522	91180103	158070518	4	17103											
KIRREL	55243	broad.mit.edu	37	chr1	158047873	158047873	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctgacgacgcctcttacGagtgccaggccacggaggcc	7	7	12	15	4	2	1	0	1	2	0	3	4	2	2	4	3	2	0	4	3	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:158047873G>T	uc001frn.3	+	3	699	c.295G>T	c.(295-297)GAG>TAG	p.E99*	KIRREL_uc010pib.1_Intron|KIRREL_uc009wsq.2_Nonsense_Mutation_p.E38*	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	99	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CGCCTCTTACGAGTGCCAGGC	0.627													35	87					1.60099e-16	2.11656e-16	1	0	T	158047873	T	T	158047873	4	4	86	1	0	0	0	0	0	1	0	0	8363	1059	37	3	305	3	KIRREL	1	158047873	Nonsense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	66867770	158047873	91202748	5	17104											
CRP	1401	broad.mit.edu	37	chr1	159683905	159683905	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtatccgactctttgggaaAcacaaaagccttcctcgaca	13	9	7	12	2	1	0	0	0	1	0	4	3	3	1	3	1	2	1	3	1	4	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:159683905A>G	uc001ftw.2	-	2	189	c.85T>C	c.(85-87)TTT>CTT	p.F29L	CRP_uc001ftx.1_Missense_Mutation_p.F29L|CRP_uc001fty.1_5'Flank	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	29	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	TCTTTGGGAAACACAAAAGCC	0.458													11	78					0	0	0	0	G	159683905	G	G	159683905	3	3	86	1	0	0	0	0	1	0	0	0	3910	43	2	5	593	5	CRP	1	159683905	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	1636032	159683905	89566716	6	17105											
BAT2L2	23215	broad.mit.edu	37	chr1	171505303	171505303	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcagcctatgcagcctcatCctcagcatttggcttctatg	8	13	7	13	0	4	0	3	0	1	0	5	0	5	0	3	1	4	3	3	1	2	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:171505303C>T	uc010pmg.1	+	14	2439	c.2173C>T	c.(2173-2175)CCT>TCT	p.P725S		NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	725	Pro-rich.						protein C-terminus binding				0						GCAGCCTCATCCTCAGCATTT	0.478													6	15					0	0	0	0	T	171505303	T	T	171505303	3	4	86	1	0	0	0	0	1	0	0	0	1323	855	30	2	2223	2	BAT2L2	1	171505303	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	11821398	171505303	77745318	7	17106											
PAPPA2	60676	broad.mit.edu	37	chr1	176563768	176563768	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgcttcttcttctccctctGcaccgaccgcgtgaagaaag	7	11	8	15	4	4	2	0	1	4	1	6	3	4	2	3	0	1	2	3	0	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:176563768G>T	uc001gkz.2	+	3	2192	c.1028G>T	c.(1027-1029)TGC>TTC	p.C343F	PAPPA2_uc001gky.1_Missense_Mutation_p.C343F|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	343					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTCTCCCTCTGCACCGACCGC	0.577													14	55					6.31663e-08	7.49349e-08	1	0	T	176563768	T	T	176563768	3	4	86	1	0	0	0	0	1	0	0	0	11487	1319	46	4	1034	4	PAPPA2	1	176563768	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	5058465	176563768	72686853	8	17107											
FAM5B	57795	broad.mit.edu	37	chr1	177245369	177245369	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcctgagtatctgcgtgagCgctttgtagctgcagcactc	6	12	12	11	2	1	2	0	2	1	0	2	2	1	2	1	0	6	6	1	0	2	3	rs145109858	byFrequency	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:177245369C>G	uc001glf.2	+	6	1123	c.811C>G	c.(811-813)CGC>GGC	p.R271G	FAM5B_uc010pna.1_Missense_Mutation_p.R21G|FAM5B_uc001glg.2_Missense_Mutation_p.R166G	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	271						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TCTGCGTGAGCGCTTTGTAGC	0.562													9	61					0	0	0	0	G	177245369	G	G	177245369	3	3	86	1	0	0	0	0	1	0	0	0	5625	768	27	3	829	3	FAM5B	1	177245369	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	681601	177245369	72005252	9	17108											
C1orf125	126859	broad.mit.edu	37	chr1	179363133	179363133	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtgatggaccagcgcatttTagaagaattgtataatttca	14	13	9	5	1	1	3	1	1	0	2	1	4	1	4	1	1	1	2	1	1	5	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:179363133T>A	uc001gmo.2	+	10	1086	c.959T>A	c.(958-960)TTA>TAA	p.L320*	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Nonsense_Mutation_p.L108*|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Nonsense_Mutation_p.L320*	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	320	Potential.										0						CAGCGCATTTTAGAAGAATTG	0.373													22	52					0	0	0	0	A	179363133	A	A	179363133	4	1	86	1	0	0	0	0	0	1	0	0	2002	1764	61	5	993	5	C1orf125	1	179363133	Nonsense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	2117764	179363133	69887488	10	17109											
CFHR4	10877	broad.mit.edu	37	chr1	196883745	196883745	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaaatcagttatggaaacaCcacaggttccatagtgtgtg	13	11	10	7	0	1	1	1	1	0	0	2	2	2	2	2	2	1	2	2	2	4	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:196883745C>G	uc001gto.2	+	4	629	c.560C>G	c.(559-561)ACC>AGC	p.T187S	CFHR4_uc009wyy.2_Missense_Mutation_p.T433S|CFHR4_uc001gtp.2_Missense_Mutation_p.T434S	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	187	Sushi 3.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						TATGGAAACACCACAGGTTCC	0.358													7	43					0	0	0	0	G	196883745	G	G	196883745	3	3	86	1	0	0	0	0	1	0	0	0	3302	507	18	4	574	4	CFHR4	1	196883745	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	17520612	196883745	52366876	11	17110											
ZNF281	23528	broad.mit.edu	37	chr1	200378334	200378334	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacgccgtgactcccccctTcaccgcctcctaggcctgga	5	8	9	19	3	1	2	1	2	0	0	3	3	3	3	8	2	0	0	8	2	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:200378334T>A	uc001gve.2	-	2	607	c.500A>T	c.(499-501)GAA>GTA	p.E167V	uc010ppi.1_5'Flank|ZNF281_uc001gvf.1_Missense_Mutation_p.E167V|ZNF281_uc001gvg.1_Missense_Mutation_p.E131V	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	167					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ACTCCCCCCTTCACCGCCTCC	0.527													10	67					0	0	0	0	A	200378334	A	A	200378334	3	1	86	1	0	0	0	0	1	0	0	0	17885	1783	62	5	2191	5	ZNF281	1	200378334	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	3494589	200378334	48872287	12	17111											
KLHL12	59349	broad.mit.edu	37	chr1	202887471	202887471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taatacccaggcaattagaaGggtccaactgactttctaag	14	10	8	9	0	1	2	0	1	1	1	2	2	2	2	2	2	2	1	2	2	7	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:202887471G>A	uc001gyo.1	-	4	595	c.395C>T	c.(394-396)CCT>CTT	p.P132L	KLHL12_uc001gyn.1_5'UTR|KLHL12_uc010pqc.1_Missense_Mutation_p.P170L|KLHL12_uc009xah.1_Missense_Mutation_p.P132L	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	132					Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			GCAATTAGAAGGGTCCAACTG	0.448													12	57					0	0	0	0	A	202887471	A	A	202887471	3	1	86	1	0	0	0	0	1	0	0	0	8407	1000	35	4	1347	4	KLHL12	1	202887471	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	2509137	202887471	46363150	13	17112											
EDARADD	128178	broad.mit.edu	37	chr1	236590709	236590709	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagctgaagaatgtgatacaAttactttgaactgcccacga	14	11	8	8	1	0	4	0	3	0	1	0	5	0	4	1	0	5	1	1	0	7	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:236590709A>G	uc001hxu.1	+	4	243	c.178A>G	c.(178-180)ATT>GTT	p.I60V	EDARADD_uc001hxv.1_Missense_Mutation_p.I50V	NM_145861	NP_665860	Q8WWZ3	EDAD_HUMAN	EDAR-associated death domain isoform A	60					cell differentiation|signal transduction	cytoplasm					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.0232)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ATGTGATACAATTACTTTGAA	0.229													3	8					0	0	0	0	G	236590709	G	G	236590709	3	3	86	1	0	0	0	0	1	0	0	0	4928	101	4	5	227	5	EDARADD	1	236590709	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	33703238	236590709	12659912	14	17113											
CHRM3	1131	broad.mit.edu	37	chr1	240071629	240071629	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctcgaagctgcagcagttAcgaacttcaacagcaaagca	14	8	8	11	2	2	0	1	0	1	0	3	2	2	0	0	0	8	6	0	0	5	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:240071629A>G	uc001hyp.2	+	5	1657	c.878A>G	c.(877-879)TAC>TGC	p.Y293C		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	293	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TGCAGCAGTTACGAACTTCAA	0.547													7	63					0	0	0	0	G	240071629	G	G	240071629	3	3	86	1	0	0	0	0	1	0	0	0	3393	391	14	5	880	5	CHRM3	1	240071629	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	3480920	240071629	9178992	15	17114											
FMN2	56776	broad.mit.edu	37	chr1	240492727	240492727	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattttcagaaagcatttgcTcaattcgtcgcaaactggaa	13	12	7	9	2	2	1	2	0	0	1	4	2	2	2	0	1	3	3	0	1	4	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr1:240492727T>A	uc010pyd.1	+	10	4621	c.4396T>A	c.(4396-4398)TCA>ACA	p.S1466T	FMN2_uc010pye.1_Missense_Mutation_p.S1470T|FMN2_uc010pyf.1_Missense_Mutation_p.S112T|FMN2_uc010pyg.1_Missense_Mutation_p.S62T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1466	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AAGCATTTGCTCAATTCGTCG	0.408													13	78					0	0	0	0	A	240492727	A	A	240492727	3	1	86	1	0	0	0	0	1	0	0	0	5982	1551	54	5	4434	5	FMN2	1	240492727	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	421098	240492727	8757894	16	17115											
VSNL1	7447	broad.mit.edu	37	chr2	17836566	17836566	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcagcaagatggataagAacaaagatgaccagattaca	18	9	8	6	0	1	5	1	1	0	4	1	6	1	6	1	1	3	1	1	1	5	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:17836566A>T	uc002rcm.2	+	4	865	c.481A>T	c.(481-483)AAC>TAC	p.N161Y		NM_003385	NP_003376	P62760	VISL1_HUMAN	visinin-like 1	161	3 (Potential).|EF-hand 4.						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GATGGATAAGAACAAAGATGA	0.428													26	26					0	0	0	0	T	17836566	T	T	17836566	3	4	86	1	0	0	0	0	1	0	0	0	17295	246	9	5	491	5	VSNL1	2	17836566	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08		17836566	225362807	17	17116											
GTF3C2	2976	broad.mit.edu	37	chr2	27550056	27550056	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagactaccttatgaatagcCtccagctgcagcctgtccag	10	9	9	13	0	0	2	0	1	0	1	2	3	2	2	5	0	5	2	5	0	4	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:27550056C>G	uc002rjv.1	-	19	2868	c.2505G>C	c.(2503-2505)GAG>GAC	p.E835D	MPV17_uc002rjt.2_5'Flank|GTF3C2_uc010eyy.1_Missense_Mutation_p.E290D|GTF3C2_uc002rju.1_Missense_Mutation_p.E846D|GTF3C2_uc002rjw.1_Missense_Mutation_p.E835D	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	835	WD 4.					transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATGAATAGCCTCCAGCTGCA	0.542													6	42					0	0	0	0	G	27550056	G	G	27550056	3	3	86	1	0	0	0	0	1	0	0	0	6912	680	24	4	238	4	GTF3C2	2	27550056	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	9713490	27550056	215649317	18	17117											
LHCGR	3973	broad.mit.edu	37	chr2	48936097	48936097	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttctactcacaaggttttcgGccctgtggccccacggaagg	7	10	11	13	2	2	0	1	0	1	0	3	1	2	1	3	5	1	1	3	5	3	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:48936097G>T	uc002rwu.3	-	8	740	c.670C>A	c.(670-672)CCG>ACG	p.P224T	GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_RNA	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	224	Extracellular (Potential).|LRR 6.				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AAGGTTTTCGGCCCTGTGGCC	0.542									Familial_Male-Limited_Precocious_Puberty				32	149					6.02846e-25	8.43443e-25	1	0	T	48936097	T	T	48936097	3	4	86	1	0	0	0	0	1	0	0	0	8803	1203	42	4	1445	4	LHCGR	2	48936097	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	21386041	48936097	194263276	19	17118											
NRXN1	9378	broad.mit.edu	37	chr2	51255050	51255050	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtggtgttgcggaactggCggcggatgcgcacgctgtgc	4	8	19	10	6	0	0	0	0	0	0	0	2	0	2	0	5	4	3	0	5	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:51255050C>A	uc010fbq.2	-	2	1839	c.362G>T	c.(361-363)CGC>CTC	p.R121L	NRXN1_uc002rxe.3_Missense_Mutation_p.R121L|NRXN1_uc002rxd.1_Missense_Mutation_p.R121L	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	184	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCGGAACTGGCGGCGGATGCG	0.647													22	33					2.37509e-13	3.037e-13	1	0	A	51255050	A	A	51255050	3	1	86	1	0	0	0	0	1	0	0	0	10719	768	27	3	4636	3	NRXN1	2	51255050	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	2318953	51255050	191944323	20	17119											
DYSF	8291	broad.mit.edu	37	chr2	71778282	71778282	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctacacagagctcaacacagGcaaggtaagccggctggagc	13	4	12	12	1	1	1	1	0	0	1	1	2	1	2	1	4	5	4	1	4	4	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:71778282G>A	uc002sie.2	+	18	2010	c.1634G>A	c.(1633-1635)GGC>GAC	p.G545D	DYSF_uc010feg.2_Missense_Mutation_p.G576D|DYSF_uc010feh.2_Missense_Mutation_p.G531D|DYSF_uc002sig.3_Missense_Mutation_p.G531D|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.G545D|DYSF_uc010fef.2_Missense_Mutation_p.G562D|DYSF_uc010fei.2_Missense_Mutation_p.G562D|DYSF_uc010fek.2_Missense_Mutation_p.G563D|DYSF_uc010fej.2_Missense_Mutation_p.G532D|DYSF_uc010fel.2_Missense_Mutation_p.G532D|DYSF_uc010feo.2_Missense_Mutation_p.G577D|DYSF_uc010fem.2_Missense_Mutation_p.G546D|DYSF_uc010fen.2_Missense_Mutation_p.G563D|DYSF_uc002sif.2_Missense_Mutation_p.G546D	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	545	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CTCAACACAGGCAAGGTAAGC	0.627													38	53					0	0	0	0	A	71778282	A	A	71778282	3	1	86	1	0	0	0	0	1	0	0	0	4881	1203	42	4	1896	4	DYSF	2	71778282	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	20523232	71778282	171421091	21	17120											
PTCD3	55037	broad.mit.edu	37	chr2	86352147	86352147	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacgctgagagaatcttttCtctaatgccagagaaaaatg	15	10	8	8	1	2	3	0	1	2	2	3	5	2	3	1	0	2	1	1	0	5	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:86352147C>T	uc002sqw.2	+	10	812	c.746C>T	c.(745-747)TCT>TTT	p.S249F	PTCD3_uc010ytc.1_RNA|PTCD3_uc002sqx.1_5'UTR	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	249						mitochondrion	protein binding			ovary(1)	1						AGAATCTTTTCTCTAATGCCA	0.318													5	35					0	0	0	0	T	86352147	T	T	86352147	3	4	86	1	0	0	0	0	1	0	0	0	12791	913	32	2	784	2	PTCD3	2	86352147	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	14573865	86352147	156847226	22	17121											
SMYD1	150572	broad.mit.edu	37	chr2	88407935	88407935	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caactgggcatggccgtgatGcgggcagggctgaccaactg	8	6	16	11	2	0	2	0	2	0	0	0	2	0	2	2	4	3	3	2	4	2	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:88407935G>A	uc002ssr.2	+	9	1193	c.1191G>A	c.(1189-1191)ATG>ATA	p.M397I	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Missense_Mutation_p.M93I	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						TGGCCGTGATGCGGGCAGGGC	0.542													29	36					0	0	0	0	A	88407935	A	A	88407935	3	1	86	1	0	0	0	0	1	0	0	0	14885	1319	46	4	1225	4	SMYD1	2	88407935	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	2055788	88407935	154791438	23	17122											
BUB1	699	broad.mit.edu	37	chr2	111416240	111416240	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggctgcactttggatggCgttgcctgaaccattcccag	7	11	12	11	1	0	1	0	1	0	0	1	3	1	2	3	3	3	3	3	3	1	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:111416240C>T	uc002tgc.2	-	12	1468	c.1356G>A	c.(1354-1356)ACG>ACA	p.T452T	BUB1_uc010yxh.1_Silent_p.T432T|BUB1_uc010fkb.2_Silent_p.T452T	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	452					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		CTTTGGATGGCGTTGCCTGAA	0.433													17	34					0	0	0	0	T	111416240	T	T	111416240	2	4	86	1	0	0	0	0	0	0	0	1	1575	755	27	1		1	BUB1	2	111416240	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	23008305	111416240	131783133	24	17123											
YSK4	80122	broad.mit.edu	37	chr2	135743820	135743820	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actttactaagagatgctgtAttctgcttttcttgctgtac	8	18	7	8	0	2	1	0	0	2	1	2	2	2	1	0	0	5	5	0	0	4	9			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:135743820A>T	uc002tue.1	-	7	2653	c.2622T>A	c.(2620-2622)AAT>AAA	p.N874K	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.N761K|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.N602K|YSK4_uc002tui.3_Missense_Mutation_p.N891K	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	874							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GAGATGCTGTATTCTGCTTTT	0.378													22	42					0	0	0	0	T	135743820	T	T	135743820	3	4	86	1	0	0	0	0	1	0	0	0	17563	446	16	5	1380	5	YSK4	2	135743820	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	24327580	135743820	107455553	25	17124											
CACNB4	785	broad.mit.edu	37	chr2	152698521	152698521	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggttgtgtgggtggcacGccagtacgcctccaggtact	6	10	14	11	2	0	0	0	0	0	0	1	0	1	0	3	4	2	4	3	4	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:152698521G>A	uc002tya.2	-	13	1266	c.1198C>T	c.(1198-1200)CGT>TGT	p.R400C	CACNB4_uc002txy.2_Missense_Mutation_p.R366C|CACNB4_uc002txz.2_Missense_Mutation_p.R382C|CACNB4_uc010fnz.2_Intron	NM_000726	NP_000717	O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4	400					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	TGGGTGGCACGCCAGTACGCC	0.493													25	63					0	0	0	0	A	152698521	A	A	152698521	3	1	86	1	0	0	0	0	1	0	0	0	2567	1087	38	1	372	1	CACNB4	2	152698521	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	16954701	152698521	90500852	26	17125											
SCN2A	6326	broad.mit.edu	37	chr2	166172118	166172118	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgaaaaacagaagaaagaaAaagaaacagaaagaacagtc	26	2	8	5	0	0	7	0	1	0	6	1	7	0	7	0	0	3	0	0	0	9	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:166172118A>G	uc002udc.2	+	11	1811	c.1521A>G	c.(1519-1521)AAA>AAG	p.K507K	SCN2A_uc002udd.2_Silent_p.K507K|SCN2A_uc002ude.2_Silent_p.K507K	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	507					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	gaagaaagaaaaagaaacaga	0.303													14	29					0	0	0	0	G	166172118	G	G	166172118	2	3	86	1	0	0	0	0	0	0	0	1	13981	11	1	5		5	SCN2A	2	166172118	Silent	SNP	A	TCGA-CN-6995-01A-31D-2012-08	13473597	166172118	77027255	27	17126											
ABCB11	8647	broad.mit.edu	37	chr2	169787239	169787239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgctagtgcttttgccacatCcactgctcccaacaaacgcc	9	10	6	16	1	0	0	0	0	0	0	2	0	2	0	4	0	6	3	4	0	3	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:169787239C>T	uc002ueo.1	-	25	3473	c.3347G>A	c.(3346-3348)GGA>GAA	p.G1116E	ABCB11_uc010zda.1_Missense_Mutation_p.G558E|ABCB11_uc010zdb.1_Missense_Mutation_p.G592E	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1116	Cytoplasmic (Potential).|ATP 2 (Potential).|ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TTTGCCACATCCACTGCTCCC	0.463													6	19					0	0	0	0	T	169787239	T	T	169787239	3	4	86	1	0	0	0	0	1	0	0	0	42	855	30	2	634	2	ABCB11	2	169787239	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	3615121	169787239	73412134	28	17127											
TTN	7273	broad.mit.edu	37	chr2	179650467	179650467	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttagatctgtagttttcttGatctgcattgaaatgaaact	11	17	8	5	0	3	4	0	3	3	1	3	4	3	4	0	0	2	4	0	0	4	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:179650467G>A	uc010zfg.1	-	15	2597	c.2373C>T	c.(2371-2373)ATC>ATT	p.I791I	TTN_uc010zfh.1_Silent_p.I745I|TTN_uc010zfi.1_Silent_p.I745I|TTN_uc010zfj.1_Silent_p.I745I|TTN_uc002unb.2_Silent_p.I791I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	791							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGTTTTCTTGATCTGCATTG	0.413													12	66					0	0	0	0	A	179650467	A	A	179650467	2	1	86	1	0	0	0	0	0	0	0	1	16803	1280	45	2		2	TTN	2	179650467	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	9863228	179650467	63548906	29	17128											
PGAP1	80055	broad.mit.edu	37	chr2	197737751	197737751	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagatactggttatttcttCtgttaaaacatttaaaaaat	16	17	4	4	0	2	1	0	0	2	1	2	1	2	1	0	1	2	2	0	1	8	8			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:197737751C>A	uc002utw.2	-	17	1667	c.1553_splice	c.e17-1	p.E518_splice	PGAP1_uc002utx.2_Splice_Site_p.E344_splice|PGAP1_uc002uty.1_Splice_Site_p.E518_splice	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase						attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						GTTATTTCTTCTGTTAAAACA	0.249													3	11					0.004672	0.00497496	1	0	A	197737751	A	A	197737751	5	1	86	1	0	0	0	0	0	0	1	0	11832	927	32	2	1260	2	PGAP1	2	197737751	Splice_Site	SNP	C	TCGA-CN-6995-01A-31D-2012-08	18087284	197737751	45461622	30	17129											
XRCC5	7520	broad.mit.edu	37	chr2	216986930	216986930	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatagtgaaaatggtgatgAtatctttagaaggtgaagat	16	12	12	1	0	1	7	0	4	1	3	1	7	1	7	0	2	0	0	0	2	7	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:216986930A>G	uc002vfy.2	+	6	777	c.637A>G	c.(637-639)ATA>GTA	p.I213V	XRCC5_uc002vfz.2_Missense_Mutation_p.I99V	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	213					double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		AATGGTGATGATATCTTTAGA	0.383								Direct_reversal_of_damage|NHEJ					14	49					0	0	0	0	G	216986930	G	G	216986930	3	3	86	1	0	0	0	0	1	0	0	0	17524	333	12	5	659	5	XRCC5	2	216986930	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	19249179	216986930	26212443	31	17130											
SLC4A3	6508	broad.mit.edu	37	chr2	220493179	220493179	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagacgtggaggaggaggAcgatgacttgggcaagacct	11	6	16	8	2	0	3	0	1	0	2	1	8	1	7	2	5	0	1	2	5	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:220493179A>G	uc002vmp.3	+	3	373	c.104A>G	c.(103-105)GAC>GGC	p.D35G	SLC4A3_uc002vmn.2_Missense_Mutation_p.D35G|SLC4A3_uc002vmo.3_Missense_Mutation_p.D35G|SLC4A3_uc010fwm.2_5'UTR	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	35	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAGGAGGAGGACGATGACTTG	0.657													5	19					0	0	0	0	G	220493179	G	G	220493179	3	3	86	1	0	0	0	0	1	0	0	0	14719	275	10	5	110	5	SLC4A3	2	220493179	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	3506249	220493179	22706194	32	17131											
UGT1A5	54579	broad.mit.edu	37	chr2	234680964	234680964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggaccgcccggtggagcCgctggacctggccgtgttct	5	7	15	14	4	1	0	0	0	1	0	1	3	1	3	5	5	1	2	5	5	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr2:234680964C>T	uc002vuw.2	+	5	1364	c.1364C>T	c.(1363-1365)CCG>CTG	p.P455L	UGT1A8_uc002vup.2_Missense_Mutation_p.P451L|UGT1A10_uc002vur.2_Missense_Mutation_p.P451L|UGT1A9_uc002vus.2_Missense_Mutation_p.P451L|UGT1A7_uc002vut.2_Missense_Mutation_p.P451L|UGT1A6_uc002vuu.2_Missense_Mutation_p.P186L|UGT1A6_uc002vuv.3_Missense_Mutation_p.P453L|UGT1A4_uc002vux.2_Missense_Mutation_p.P455L|UGT1A3_uc002vuy.2_Missense_Mutation_p.P455L|UGT1A9_uc002vva.2_RNA|UGT1A1_uc002vvb.2_Missense_Mutation_p.P454L	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	455					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		CCGGTGGAGCCGCTGGACCTG	0.587													15	84					0	0	0	0	T	234680964	T	T	234680964	3	4	86	1	0	0	0	0	1	0	0	0	17016	652	23	1	1382	1	UGT1A5	2	234680964	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	14187785	234680964	8518409	33	17132											
IL5RA	3568	broad.mit.edu	37	chr3	3146617	3146617	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggaagtaagtcagcttgcaGtatctcagtggcccccaaaa	13	8	10	10	0	2	0	2	0	1	0	3	1	2	1	2	2	2	4	2	2	5	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:3146617G>T	uc011ask.1	-	4	696	c.52C>A	c.(52-54)CTG>ATG	p.L18M	IL5RA_uc010hbq.2_Missense_Mutation_p.L18M|IL5RA_uc010hbr.2_Missense_Mutation_p.L18M|IL5RA_uc010hbs.2_Missense_Mutation_p.L18M|IL5RA_uc011asl.1_Missense_Mutation_p.L18M|IL5RA_uc011asm.1_Missense_Mutation_p.L18M|IL5RA_uc010hbt.2_Missense_Mutation_p.L18M|IL5RA_uc011asn.1_Missense_Mutation_p.L18M|IL5RA_uc010hbu.2_Missense_Mutation_p.L18M	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	18					cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		TCAGCTTGCAGTATCTCAGTG	0.333													7	12					5.68852e-11	7.15653e-11	1	0	T	3146617	T	T	3146617	3	4	86	1	0	0	0	0	1	0	0	0	7739	1020	36	4	1276	4	IL5RA	3	3146617	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08		3146617	194875813	34	17133											
FLNB	2317	broad.mit.edu	37	chr3	58109357	58109357	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acttccccgcccgggtcaagGtggagcccgccgtggacacc	6	5	13	17	4	1	0	1	0	0	0	2	2	2	2	6	4	1	0	6	4	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:58109357G>A	uc003djj.2	+	21	3829	c.3664G>A	c.(3664-3666)GTG>ATG	p.V1222M	FLNB_uc010hne.2_Missense_Mutation_p.V1222M|FLNB_uc003djk.2_Missense_Mutation_p.V1222M|FLNB_uc010hnf.2_Missense_Mutation_p.V1222M|FLNB_uc003djl.2_Missense_Mutation_p.V1053M|FLNB_uc003djm.2_Missense_Mutation_p.V1053M	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1222	Interaction with FBLP1.|Filamin 10.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCGGGTCAAGGTGGAGCCCGC	0.517													16	33					0	0	0	0	A	58109357	A	A	58109357	3	1	86	1	0	0	0	0	1	0	0	0	5966	1261	44	4	3746	4	FLNB	3	58109357	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	54962740	58109357	139913073	35	17134											
FOXP1	27086	broad.mit.edu	37	chr3	71019957	71019957	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttaataagggaagggttaCtgtgtaagaaaaacataaaa	19	11	9	2	0	0	1	0	0	0	1	0	2	0	2	0	2	2	2	0	2	9	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:71019957C>T	uc003dol.2	-	15	1976	c.1653_splice	c.e15-1	p.G551_splice	FOXP1_uc003dom.2_Splice_Site_p.G475_splice|FOXP1_uc003don.2_Splice_Site|FOXP1_uc003doo.2_Splice_Site_p.G550_splice|FOXP1_uc003dop.2_Splice_Site_p.G551_splice|FOXP1_uc003doq.1_Intron|FOXP1_uc003doi.2_Splice_Site_p.G451_splice|FOXP1_uc003doj.2_Splice_Site_p.G451_splice|FOXP1_uc003dok.2_Splice_Site_p.G364_splice|FOXP1_uc003dor.1_3'UTR	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1						cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GGAAGGGTTACTGTGTAAGAA	0.433			T	PAX5	ALL								24	40					0	0	0	0	T	71019957	T	T	71019957	5	4	86	1	0	0	0	0	0	0	1	0	6060	579	20	4	393	4	FOXP1	3	71019957	Splice_Site	SNP	C	TCGA-CN-6995-01A-31D-2012-08	12910600	71019957	127002473	36	17135											
MYH15	22989	broad.mit.edu	37	chr3	108163738	108163738	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccattggatcaaaataagtgCatccctaaatcaagaaagaa	19	8	6	8	0	2	2	2	0	0	2	3	3	3	3	2	1	1	1	2	1	8	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:108163738C>A	uc003dxa.1	-	23	2521	c.2464G>T	c.(2464-2466)GCA>TCA	p.A822S		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	822	IQ.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						AAAATAAGTGCATCCCTAAAT	0.373													18	28					1.2644e-06	1.43976e-06	1	0	A	108163738	A	A	108163738	3	1	86	1	0	0	0	0	1	0	0	0	10087	710	25	4	3456	4	MYH15	3	108163738	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	37143781	108163738	89858692	37	17136											
DPPA2	151871	broad.mit.edu	37	chr3	109031513	109031513	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaaaatcacactttcctcAtcatctacttccccctccaa	11	12	1	17	0	5	0	4	0	1	0	8	0	8	0	4	0	1	0	4	0	4	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:109031513A>T	uc003dxo.2	-	3	307	c.60T>A	c.(58-60)GAT>GAA	p.D20E		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	20						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						CACTTTCCTCATCATCTACTT	0.408													8	82					0	0	0	0	T	109031513	T	T	109031513	3	4	86	1	0	0	0	0	1	0	0	0	4756	214	8	5	860	5	DPPA2	3	109031513	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	867775	109031513	88990917	38	17137											
KTELC1	56983	broad.mit.edu	37	chr3	119199009	119199009	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgggacctcttcagagaaGatctggtaaggtaggtcctt	9	11	14	7	0	3	2	1	0	2	2	4	4	4	3	2	5	0	2	2	5	3	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:119199009G>C	uc003ecm.2	+	5	652	c.568G>C	c.(568-570)GAT>CAT	p.D190H	KTELC1_uc011biz.1_RNA|KTELC1_uc011bja.1_Missense_Mutation_p.D31H	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	190						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		CTTCAGAGAAGATCTGGTAAG	0.383													10	34					0	0	0	0	C	119199009	C	C	119199009	3	2	86	1	0	0	0	0	1	0	0	0	8623	942	33	2	586	2	KTELC1	3	119199009	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	10167496	119199009	78823421	39	17138											
KTELC1	56983	broad.mit.edu	37	chr3	119210421	119210421	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctcaagagattgctgaaaGgtgagttctgttcattttcc	10	14	10	7	0	3	3	2	2	1	1	4	4	4	3	1	1	2	4	1	1	2	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:119210421G>C	uc003ecm.2	+	10	1106	c.1022G>C	c.(1021-1023)AGG>ACG	p.R341T	KTELC1_uc011bja.1_Missense_Mutation_p.R182T	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	341						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		ATTGCTGAAAGGTGAGTTCTG	0.343													3	15					0	0	0	0	C	119210421	C	C	119210421	3	2	86	1	0	0	0	0	1	0	0	0	8623	1014	35	4	1060	4	KTELC1	3	119210421	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	11412	119210421	78812009	40	17139											
NPHP3	27031	broad.mit.edu	37	chr3	132435712	132435712	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcctatggaaggttcacttcCcaaggctccgccagtccaat	9	10	8	14	1	1	0	1	0	0	0	5	1	5	1	5	3	0	2	5	3	4	3	rs147399998		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:132435712C>T	uc003epe.1	-	4	789	c.712G>A	c.(712-714)GGA>AGA	p.G238R	NPHP3_uc003epf.1_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	238					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						GGTTCACTTCCCAAGGCTCCG	0.448													6	38					0	0	0	0	T	132435712	T	T	132435712	3	4	86	1	0	0	0	0	1	0	0	0	10634	632	22	4	3376	4	NPHP3	3	132435712	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	13225291	132435712	65586718	41	17140											
ATR	545	broad.mit.edu	37	chr3	142242944	142242944	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagagcaaccgagcttgaGagtttgcatcttggcaacct	11	9	10	11	1	1	2	0	1	1	2	1	4	1	2	2	1	5	5	2	1	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:142242944G>A	uc003eux.3	-	22	4165	c.4043C>T	c.(4042-4044)TCT>TTT	p.S1348F		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1348	HEAT 2.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CCGAGCTTGAGAGTTTGCATC	0.413								Other_conserved_DNA_damage_response_genes					7	63					0	0	0	0	A	142242944	A	A	142242944	3	1	86	1	0	0	0	0	1	0	0	0	1206	942	33	2	3995	2	ATR	3	142242944	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	9807232	142242944	55779486	42	17141											
SGEF	26084	broad.mit.edu	37	chr3	153840415	153840415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggccccagaaaagttcttcgGaacaaaaactccccctccaa	14	6	6	15	1	1	1	0	0	1	1	4	2	3	2	5	2	2	1	5	2	6	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:153840415G>A	uc011bog.1	+	2	845	c.634G>A	c.(634-636)GAA>AAA	p.E212K	uc003ezu.1_5'Flank|SGEF_uc011boh.1_Missense_Mutation_p.E212K	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	212					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AAGTTCTTCGGAACAAAAACT	0.587													59	50					0	0	0	0	A	153840415	A	A	153840415	3	1	86	1	0	0	0	0	1	0	0	0	14270	1175	41	2	636	2	SGEF	3	153840415	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	11597471	153840415	44182015	43	17142											
SI	6476	broad.mit.edu	37	chr3	164735374	164735374	+	Frame_Shift_Del	DEL	C	-	-																															caccatagcgtcatataattCccgaacctctgaagtatttg																										TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:164735374delC	uc003fei.2	-	31	3783	c.3721delG	c.(3721-3723)GAAfs	p.E1241fs		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1241	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCATATAATTCCCGAACCTCT	0.338										HNSCC(35;0.089)			---	---	---								-	164735374	-	-	164735374	7	5	86	1	0	1	0	1	0	0	0	0	14362	864	30	0	1834	0	SI	3	164735374	Frame_Shift_Del	DEL	C	TCGA-CN-6995-01A-31D-2012-08	10894959	164735374	33287056	44	17143											
MECOM	2122	broad.mit.edu	37	chr3	168838941	168838941	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccgggcatgcatgggcccgGgcaccgacatgctgagagcg	7	5	16	13	4	0	1	0	1	0	1	1	3	1	1	3	3	3	4	3	3	0	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:168838941G>T	uc003ffi.3	-	6	740	c.471C>A	c.(469-471)GCC>GCA	p.A157A	MECOM_uc010hwk.1_Silent_p.A180A|MECOM_uc003ffj.3_Silent_p.A222A|MECOM_uc011bpi.1_Silent_p.A158A|MECOM_uc003ffn.3_Silent_p.A157A|MECOM_uc003ffk.2_Silent_p.A157A|MECOM_uc003ffl.2_Silent_p.A317A|MECOM_uc011bpj.1_Silent_p.A345A|MECOM_uc011bpk.1_Silent_p.A147A|MECOM_uc010hwn.2_Silent_p.A345A	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	157	Interaction with MAPK9, SMAD3 and probably SUV39H1.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CATGGGCCCGGGCACCGACAT	0.512													49	47					3.21987e-24	4.48482e-24	1	0	T	168838941	T	T	168838941	2	4	86	1	0	0	0	0	0	0	0	1	9475	1219	43	4		4	MECOM	3	168838941	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	4103567	168838941	29183489	45	17144											
OPA1	4976	broad.mit.edu	37	chr3	193332569	193332569	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataaaaggaagtttaccactAcaaaaactacatctggtttc	17	11	5	8	0	1	0	0	0	1	0	2	1	1	1	1	2	4	2	1	2	8	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr3:193332569A>T	uc003ftm.2	+	2	324	c.90A>T	c.(88-90)CTA>CTT	p.L30L	OPA1_uc003ftg.2_Silent_p.L30L|OPA1_uc003fth.2_Silent_p.L30L|OPA1_uc003fti.2_Silent_p.L30L|OPA1_uc003ftj.2_Silent_p.L30L|OPA1_uc003ftk.2_Silent_p.L30L|OPA1_uc003ftl.2_Silent_p.L30L|OPA1_uc003ftn.2_Silent_p.L30L	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	30					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		GTTTACCACTACAAAAACTAC	0.318													47	46					0	0	0	0	T	193332569	T	T	193332569	2	4	86	1	0	0	0	0	0	0	0	1	10925	378	14	5		5	OPA1	3	193332569	Silent	SNP	A	TCGA-CN-6995-01A-31D-2012-08	24493628	193332569	4689861	46	17145											
ATP8A1	10396	broad.mit.edu	37	chr4	42576696	42576696	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttacattgcatgtcagagtaCcagttttgtcagaaaatatg	13	14	8	6	0	2	2	2	0	0	2	2	2	2	2	1	0	3	3	1	0	5	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:42576696C>G	uc003gwr.2	-	14	1467	c.1235G>C	c.(1234-1236)GGT>GCT	p.G412A	ATP8A1_uc003gws.2_Missense_Mutation_p.G412A|ATP8A1_uc011byz.1_Missense_Mutation_p.G412A	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	412	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	TGTCAGAGTACCAGTTTTGTC	0.323													4	24					0	0	0	0	G	42576696	G	G	42576696	3	3	86	1	0	0	0	0	1	0	0	0	1194	507	18	4	2355	4	ATP8A1	4	42576696	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08		42576696	148577580	47	17146											
UBA6	55236	broad.mit.edu	37	chr4	68490770	68490770	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtataattttaccagctatgCgctttgttttgaaacggtca	10	16	8	7	2	1	1	1	1	0	0	1	1	1	1	1	1	4	4	1	1	5	8	rs140996878		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:68490770C>T	uc003hdg.3	-	29	2706	c.2654G>A	c.(2653-2655)CGC>CAC	p.R885H		NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	885					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						ACCAGCTATGCGCTTTGTTTT	0.373													8	45					0	0	0	0	T	68490770	T	T	68490770	3	4	86	1	0	0	0	0	1	0	0	0	16900	768	27	1	524	1	UBA6	4	68490770	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	25914074	68490770	122663506	48	17147											
SLC4A4	8671	broad.mit.edu	37	chr4	72420881	72420881	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacccatgcctgtactctatGgtgtgttcctgtatatggga	7	15	10	9	0	1	0	0	0	1	0	2	1	2	1	3	2	3	3	3	2	5	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:72420881G>C	uc003hfy.2	+	21	2836	c.2719G>C	c.(2719-2721)GGT>CGT	p.G907R	SLC4A4_uc010iic.2_Missense_Mutation_p.G907R|SLC4A4_uc010iib.2_Missense_Mutation_p.G823R|SLC4A4_uc003hfz.2_Missense_Mutation_p.G907R|SLC4A4_uc003hgc.3_Missense_Mutation_p.G863R|SLC4A4_uc010iid.2_Missense_Mutation_p.G111R	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	907	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TGTACTCTATGGTGTGTTCCT	0.328													28	210					0	0	0	0	C	72420881	C	C	72420881	3	2	86	1	0	0	0	0	1	0	0	0	14720	1348	47	4	2918	4	SLC4A4	4	72420881	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	3930111	72420881	118733395	49	17148											
CXCL1	2919	broad.mit.edu	37	chr4	74735491	74735491	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtcccccggaccccactGcgcccaaaccgaagtcatgt	10	5	9	17	3	1	0	1	0	0	0	2	3	2	1	6	1	2	0	6	1	3	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:74735491G>A	uc003hhh.1	+	2	285	c.206G>A	c.(205-207)TGC>TAC	p.C69Y		NM_001511	NP_001502	P09341	GROA_HUMAN	chemokine (C-X-C motif) ligand 1	69					actin cytoskeleton organization|cell proliferation|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|intracellular signal transduction|negative regulation of cell proliferation|nervous system development	extracellular space|intracellular	chemokine activity|enzyme activator activity|growth factor activity				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GGACCCCACTGCGCCCAAACC	0.652													65	101					0	0	0	0	A	74735491	A	A	74735491	3	1	86	1	0	0	0	0	1	0	0	0	4094	1319	46	4	212	4	CXCL1	4	74735491	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	2314610	74735491	116418785	50	17149											
FGF5	2250	broad.mit.edu	37	chr4	81196135	81196135	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttcagcaacaaatttttagCgatgtcaaaaaaaggaaaac	19	10	6	6	1	2	0	2	0	0	0	2	2	2	1	0	1	4	1	0	1	8	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:81196135C>G	uc003hmd.2	+	2	665	c.428C>G	c.(427-429)GCG>GGG	p.A143G	FGF5_uc003hme.2_Intron	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	143					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						AAATTTTTAGCGATGTCAAAA	0.318													6	14					0	0	0	0	G	81196135	G	G	81196135	3	3	86	1	0	0	0	0	1	0	0	0	5887	768	27	3	434	3	FGF5	4	81196135	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	6460644	81196135	109958141	51	17150											
HERC6	55008	broad.mit.edu	37	chr4	89326088	89326088	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaataagccgaattagccagTccatggcagaaaaatggata	18	7	9	7	1	0	1	0	0	0	1	1	3	1	2	3	2	2	1	3	2	7	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr4:89326088T>A	uc011cdi.1	+	9	1336	c.1153T>A	c.(1153-1155)TCC>ACC	p.S385T	HERC6_uc011cdj.1_Missense_Mutation_p.S385T|HERC6_uc011cdk.1_Intron|HERC6_uc011cdl.1_Intron	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	385					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		AATTAGCCAGTCCATGGCAGA	0.428													21	45					0	0	0	0	A	89326088	A	A	89326088	3	1	86	1	0	0	0	0	1	0	0	0	7101	1667	58	5	984	5	HERC6	4	89326088	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	8129953	89326088	101828188	52	17151											
MTRR	4552	broad.mit.edu	37	chr5	7873625	7873625	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgatttctttgctcacctgcGgtatgggttactgggtaatg	6	16	12	7	1	2	1	1	1	1	0	2	1	2	1	1	3	3	4	1	3	3	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:7873625G>T	uc003jed.2	+	3	380	c.350G>T	c.(349-351)CGG>CTG	p.R117L	MTRR_uc010itn.1_Intron|MTRR_uc003jee.3_Missense_Mutation_p.R90L|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_Intron|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	117	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	GCTCACCTGCGGTATGGGTTA	0.443													11	42					2.27111e-07	2.65388e-07	1	0	T	7873625	T	T	7873625	3	4	86	1	0	0	0	0	1	0	0	0	10014	1116	39	3	360	3	MTRR	5	7873625	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08		7873625	173041635	53	17152											
ANKRD34B	340120	broad.mit.edu	37	chr5	79855683	79855683	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgatcgacatgtttggtCttacaagcgatcattaaagg	11	13	11	6	2	2	1	1	1	1	0	3	3	2	1	0	3	2	1	0	3	4	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:79855683C>T	uc010jam.2	-	4	506	c.156G>A	c.(154-156)AAG>AAA	p.K52K	ANKRD34B_uc003kgw.2_Silent_p.K52K|ANKRD34B_uc010jan.2_Silent_p.K52K	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	52	ANK 2.					cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		CATGTTTGGTCTTACAAGCGA	0.463													23	143					0	0	0	0	T	79855683	T	T	79855683	2	4	86	1	0	0	0	0	0	0	0	1	663	912	32	2		2	ANKRD34B	5	79855683	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	71982058	79855683	101059577	54	17153											
MEF2C	4208	broad.mit.edu	37	chr5	88047801	88047801	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagggttgctgtacaccaaActgttgtggctggacactgg	9	10	13	9	0	0	0	0	0	0	0	0	1	0	1	1	4	3	5	1	4	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:88047801A>C	uc003kjj.2	-	5	1135	c.462T>G	c.(460-462)AGT>AGG	p.S154R	MEF2C_uc003kji.2_Missense_Mutation_p.S154R|MEF2C_uc003kjk.2_Missense_Mutation_p.S154R|MEF2C_uc003kjm.2_Missense_Mutation_p.S152R|MEF2C_uc003kjl.2_Missense_Mutation_p.S172R	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	154	Ser-rich.				apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		TGTACACCAAACTGTTGTGGC	0.493										HNSCC(66;0.2)			13	89					0	0	0	0	C	88047801	C	C	88047801	3	2	86	1	0	0	0	0	1	0	0	0	9510	40	2	5	987	5	MEF2C	5	88047801	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	8192118	88047801	92867459	55	17154											
MCTP1	79772	broad.mit.edu	37	chr5	94288963	94288963	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taagatgatcaaccagaataCaagctttttcttcccacaca	15	11	4	11	0	2	3	1	1	1	2	3	3	3	3	2	0	3	1	2	0	5	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:94288963C>G	uc003kkx.2	-	3	941	c.941G>C	c.(940-942)TGT>TCT	p.C314S	MCTP1_uc003kkv.2_Missense_Mutation_p.C93S|MCTP1_uc003kkw.2_Missense_Mutation_p.C93S|MCTP1_uc003kkz.2_5'UTR	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	314	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		AACCAGAATACAAGCTTTTTC	0.368													6	21					0	0	0	0	G	94288963	G	G	94288963	3	3	86	1	0	0	0	0	1	0	0	0	9453	478	17	4	2142	4	MCTP1	5	94288963	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	6241162	94288963	86626297	56	17155											
RFESD	317671	broad.mit.edu	37	chr5	94989858	94989858	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacattaaaaaatctgaaagAatgacagctgttgtccatga	17	10	8	6	0	1	4	0	3	1	1	2	5	2	4	1	0	1	2	1	0	5	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:94989858A>T	uc003klf.2	+	3	1485	c.93A>T	c.(91-93)AGA>AGT	p.R31S	RFESD_uc003klg.2_Missense_Mutation_p.R84S|RFESD_uc011cun.1_Missense_Mutation_p.R84S|SPATA9_uc010jbh.1_Intron|SPATA9_uc003klh.1_Intron|SPATA9_uc003kli.1_Intron	NM_173362	NP_775498	Q8TAC1	RFESD_HUMAN	Rieske (Fe-S) domain containing isoform 2	31	Rieske 2.|Rieske 1.						2 iron, 2 sulfur cluster binding|metal ion binding|oxidoreductase activity				0		all_cancers(142;0.000215)|all_epithelial(76;7.43e-07)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)|Colorectal(57;0.162)		all cancers(79;5.94e-17)		AATCTGAAAGAATGACAGCTG	0.383													8	34					0	0	0	0	T	94989858	T	T	94989858	3	4	86	1	0	0	0	0	1	0	0	0	13314	243	9	5	262	5	RFESD	5	94989858	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	700895	94989858	85925402	57	17156											
PCDHB9	56127	broad.mit.edu	37	chr5	140567435	140567435	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aactcttttttccatattaaAattagtggcagtgatgaagg	13	15	8	5	0	1	2	0	2	1	0	2	2	2	2	1	2	1	1	1	2	6	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:140567435A>C	uc003liw.1	+	1	543	c.543A>C	c.(541-543)AAA>AAC	p.K181N		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	181	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCATATTAAAATTAGTGGCA	0.448													6	143					0	0	0	0	C	140567435	C	C	140567435	3	2	86	1	0	0	0	0	1	0	0	0	11603	11	1	5	545	5	PCDHB9	5	140567435	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	45577577	140567435	40347825	58	17157											
PCDHGB2	56103	broad.mit.edu	37	chr5	140741362	140741362	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcctgcgcgtgttagtgggcGacctcaatgacaatgcgcca	8	8	13	12	4	1	1	1	1	0	0	1	2	1	1	3	1	2	1	3	1	3	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:140741362G>C	uc003ljs.1	+	1	1660	c.1660G>C	c.(1660-1662)GAC>CAC	p.D554H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.D554H|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	554	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTAGTGGGCGACCTCAATGA	0.687													41	58					0	0	0	0	C	140741362	C	C	140741362	3	2	86	1	0	0	0	0	1	0	0	0	11617	1058	37	3	1662	3	PCDHGB2	5	140741362	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	173927	140741362	40173898	59	17158											
PCDHGC4	56098	broad.mit.edu	37	chr5	140866933	140866933	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctttcctgctggcacctgTgcctgtctcaccagatctcg	4	13	9	15	1	2	1	1	0	2	1	5	1	3	1	4	1	3	3	4	1	0	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:140866933T>C	uc003lky.1	+	1	2193	c.2193T>C	c.(2191-2193)TGT>TGC	p.C731C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Silent_p.C731C|PCDHGC5_uc011dbc.1_5'Flank|PCDHGC5_uc003lla.1_5'Flank	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	731	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGCACCTGTGCCTGTCTCA	0.537													8	61					0	0	0	0	C	140866933	C	C	140866933	2	2	86	1	0	0	0	0	0	0	0	1	11624	1702	59	5		5	PCDHGC4	5	140866933	Silent	SNP	T	TCGA-CN-6995-01A-31D-2012-08	125571	140866933	40048327	60	17159											
ARAP3	64411	broad.mit.edu	37	chr5	141033932	141033932	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcccctacttcctcatacActggctcctcgtacacaggc	8	9	7	17	1	1	0	1	0	0	0	4	0	3	0	4	3	3	2	4	3	3	4	rs142227089		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr5:141033932A>G	uc003llm.2	-	33	4298	c.4220T>C	c.(4219-4221)GTG>GCG	p.V1407A	ARAP3_uc003lll.2_Missense_Mutation_p.V358A|ARAP3_uc011dbe.1_Missense_Mutation_p.V1056A|ARAP3_uc003lln.2_Missense_Mutation_p.V1238A	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1407					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						TTCCTCATACACTGGCTCCTC	0.582													10	91					0	0	0	0	G	141033932	G	G	141033932	3	3	86	1	0	0	0	0	1	0	0	0	840	159	6	5	418	5	ARAP3	5	141033932	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	166999	141033932	39881328	61	17160											
SERPINB6	5269	broad.mit.edu	37	chr6	2948568	2948568	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggccgcagaagagaatcccGttggtcttgctgtgctggat	7	10	14	10	3	1	2	0	0	1	2	2	4	2	3	2	3	2	4	2	3	2	2	rs145397970	byFrequency	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:2948568G>T	uc003muk.2	-	6	3090	c.1095C>A	c.(1093-1095)AAC>AAA	p.N365K	SERPINB6_uc003mui.2_Missense_Mutation_p.N248K|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Missense_Mutation_p.N365K|SERPINB6_uc003mum.2_Missense_Mutation_p.N365K|SERPINB6_uc003mun.2_Missense_Mutation_p.N365K|SERPINB6_uc003muo.2_Missense_Mutation_p.N365K	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	365					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	AGAGAATCCCGTTGGTCTTGC	0.602													34	36					5.97227e-30	8.46976e-30	1	0	T	2948568	T	T	2948568	3	4	86	1	0	0	0	0	1	0	0	0	14170	1136	40	3	39	3	SERPINB6	6	2948568	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08		2948568	168166499	62	17161											
HIST1H3D	8351	broad.mit.edu	37	chr6	26197234	26197234	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgagctctgaaaacgcagaTcagtcttgaagtcctgcgcg	10	8	11	12	4	3	3	1	2	2	1	4	4	4	3	2	0	3	2	2	0	3	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:26197234T>A	uc003ngv.2	-	2	642	c.245A>T	c.(244-246)GAT>GTT	p.D82V	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	82					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				AAAACGCAGATCAGTCTTGAA	0.607													18	88					0	0	0	0	A	26197234	A	A	26197234	3	1	86	1	0	0	0	0	1	0	0	0	7197	1435	50	5	169	5	HIST1H3D	6	26197234	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	23248666	26197234	144917833	63	17162											
HIST1H3G	8355	broad.mit.edu	37	chr6	26271403	26271403	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgagcgatttctcgcaccagGcgttggaaaggcaacttgcg	9	9	13	10	4	1	1	0	1	1	0	2	3	1	2	1	3	3	3	1	3	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:26271403G>A	uc003nhi.2	-	1	210	c.210C>T	c.(208-210)CGC>CGT	p.R70R	uc003nhj.2_5'Flank|HIST1H2BI_uc003nhk.2_5'Flank	NM_003534	NP_003525	P68431	H31_HUMAN	H3 histone family, member H	70				R -> C (in Ref. 13; AAH67493).	blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						CTCGCACCAGGCGTTGGAAAG	0.602													12	138					0	0	0	0	A	26271403	A	A	26271403	2	1	86	1	0	0	0	0	0	0	0	1	7200	1190	42	4		4	HIST1H3G	6	26271403	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	74169	26271403	144843664	64	17163											
HIST1H3H	8357	broad.mit.edu	37	chr6	27775211	27775211	+	5'Flank	DEL	C	-	-																															aaatgatttatgacccctcgCcccccagtgataggaagagc																										TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:27775211delC	uc003njm.2	+							NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h						blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						TGACCCCTCGCCCCCCAGTGA	0.418													---	---	---								-	27775211	-	-	27775211	6	5	86	0	1	1	0	1	0	0	0	0	7201	754	26	0		0	HIST1H3H	6	27775211	5'Flank	DEL	C	TCGA-CN-6995-01A-31D-2012-08	1503808	27775211	143339856	65	17164											
OR10C1	442194	broad.mit.edu	37	chr6	29407954	29407954	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtctccactgatgctgccctCcagtcccctatgtacttctt	5	14	6	16	0	2	1	0	1	2	0	5	1	4	1	5	0	3	2	5	0	2	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:29407954C>A	uc011dlp.1	+	1	162	c.162C>A	c.(160-162)CTC>CTA	p.L54L	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	54	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATGCTGCCCTCCAGTCCCCTA	0.562													54	92					5.57489e-27	7.83498e-27	1	0	A	29407954	A	A	29407954	2	1	86	1	0	0	0	0	0	0	0	1	10952	842	30	2		2	OR10C1	6	29407954	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	1632743	29407954	141707113	66	17165											
VARS	7407	broad.mit.edu	37	chr6	31752467	31752467	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcgtgaagccggacaaaggCctctgtcacagctgctgaga	10	7	12	12	2	2	2	1	2	1	1	3	4	2	3	2	2	3	2	2	2	2	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:31752467C>A	uc003nxe.2	-	11	1795	c.1372G>T	c.(1372-1374)GCC>TCC	p.A458S	VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	458					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	CGGACAAAGGCCTCTGTCACA	0.592													24	53					4.47668e-21	6.07271e-21	1	0	A	31752467	A	A	31752467	3	1	86	1	0	0	0	0	1	0	0	0	17191	739	26	4	2502	4	VARS	6	31752467	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	2344513	31752467	139362600	67	17166											
DOM3Z	1797	broad.mit.edu	37	chr6	31938542	31938542	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggcggctgcgtagcacaGagcagaaggccacgttggtg	9	5	16	11	3	0	2	0	0	0	2	0	2	0	2	2	4	3	5	2	4	2	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:31938542G>A	uc003nyo.1	-	3	1187	c.653C>T	c.(652-654)TCT>TTT	p.S218F	DOM3Z_uc003nyp.1_Missense_Mutation_p.S218F|DOM3Z_uc003nyq.1_Intron|DOM3Z_uc003nyr.1_Missense_Mutation_p.S218F|DOM3Z_uc003nys.1_3'UTR|DOM3Z_uc010jtl.1_3'UTR|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	DOM-3 homolog Z	218							identical protein binding|metal ion binding|nucleotide binding				0						GCGTAGCACAGAGCAGAAGGC	0.622													6	42					0	0	0	0	A	31938542	A	A	31938542	3	1	86	1	0	0	0	0	1	0	0	0	4727	942	33	2	553	2	DOM3Z	6	31938542	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	186075	31938542	139176525	68	17167											
PM20D2	135293	broad.mit.edu	37	chr6	89862895	89862895	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaatgaaaccaacctggAgagttcatggtatgaatgtc	15	9	10	7	0	1	3	1	2	0	1	2	4	1	3	2	2	3	3	2	2	5	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:89862895A>T	uc003pmz.2	+	3	843	c.748A>T	c.(748-750)AGA>TGA	p.R250*		NM_001010853	NP_001010853	Q8IYS1	P20D2_HUMAN	aminoacylase 1-like 2	250							hydrolase activity				0		all_cancers(76;9.47e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00813)		ACCAACCTGGAGAGTTCATGG	0.348													18	29					0	0	0	0	T	89862895	T	T	89862895	4	4	86	1	0	0	0	0	0	1	0	0	12184	296	11	5	758	5	PM20D2	6	89862895	Nonsense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	57924353	89862895	81252172	69	17168											
EPHA7	2045	broad.mit.edu	37	chr6	94068039	94068039	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catcttcacattcacatctgGaggagccttctttatcagaa	11	13	6	11	0	6	1	3	0	3	1	6	3	6	3	1	2	1	0	1	2	2	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:94068039G>T	uc003poe.2	-	4	1164	c.923C>A	c.(922-924)TCC>TAC	p.S308Y	EPHA7_uc003pof.2_Missense_Mutation_p.S308Y|EPHA7_uc011eac.1_Missense_Mutation_p.S308Y	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	308	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TTCACATCTGGAGGAGCCTTC	0.463													43	41					3.7052e-28	5.23087e-28	1	0	T	94068039	T	T	94068039	3	4	86	1	0	0	0	0	1	0	0	0	5196	1174	41	2	2129	2	EPHA7	6	94068039	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	4205144	94068039	77047028	70	17169											
WASF1	8936	broad.mit.edu	37	chr6	110421760	110421760	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacttcatcaaattctgaatCatcttccgaatcactatatt	13	16	2	10	1	6	1	4	1	2	0	7	2	7	1	1	0	1	0	1	0	6	7			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:110421760C>T	uc003ptv.1	-	11	2482	c.1645G>A	c.(1645-1647)GAT>AAT	p.D549N	WASF1_uc003ptw.1_Missense_Mutation_p.D549N|WASF1_uc003ptx.1_Missense_Mutation_p.D549N|WASF1_uc003pty.1_Missense_Mutation_p.D549N	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	549					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		AATTCTGAATCATCTTCCGAA	0.393													11	22					0	0	0	0	T	110421760	T	T	110421760	3	4	86	1	0	0	0	0	1	0	0	0	17320	826	29	2	38	2	WASF1	6	110421760	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	16353721	110421760	60693307	71	17170											
LAMA4	3910	broad.mit.edu	37	chr6	112537599	112537601	+	In_Frame_Del	DEL	GTT	-	-																															cctgagccgtccaaacactcGttggaattgccattacagtc																										TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:112537599_112537601delGTT	uc003pvu.2	-	3	574_576	c.265_267delAAC	c.(265-267)AACdel	p.N89del	LAMA4_uc003pvv.2_In_Frame_Del_p.N89del|LAMA4_uc003pvt.2_In_Frame_Del_p.N89del|LAMA4_uc003pvw.2_In_Frame_Del_p.N89del	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	89	Laminin EGF-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CCAAACACTCGTTGGAATTGCCA	0.453													---	---	---								-	112537601	-	-	112537599	7	5	86	1	0	1	0	1	0	0	0	0	8648	1136	40	0	5352	0	LAMA4	6	112537599	In_Frame_Del	DEL	GTT	TCGA-CN-6995-01A-31D-2012-08	2115839	112537599	58577468	72	17171											
PTPRK	5796	broad.mit.edu	37	chr6	128304088	128304088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagtttctccacataagcagGcttctaaaatggcatcatga	13	11	7	10	0	3	1	1	1	2	0	4	1	3	1	1	2	1	4	1	2	3	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:128304088G>A	uc003qbk.2	-	24	3789	c.3422C>T	c.(3421-3423)GCC>GTC	p.A1141V	PTPRK_uc003qbj.2_Missense_Mutation_p.A1142V|PTPRK_uc010kfc.2_Missense_Mutation_p.A1148V|PTPRK_uc011ebu.1_Missense_Mutation_p.A1164V	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1141	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ACATAAGCAGGCTTCTAAAAT	0.333													8	68					0	0	0	0	A	128304088	A	A	128304088	3	1	86	1	0	0	0	0	1	0	0	0	12870	1203	42	4	925	4	PTPRK	6	128304088	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	15766489	128304088	42810979	73	17172											
GRM1	2911	broad.mit.edu	37	chr6	146720389	146720389	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccattctgtcctacccaagTatcaaggaagtctaccttat	11	12	5	13	0	3	0	1	0	2	0	4	1	4	1	4	1	2	1	4	1	7	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:146720389T>A	uc010khw.1	+	8	2684	c.2214T>A	c.(2212-2214)AGT>AGA	p.S738R	GRM1_uc010khv.1_Missense_Mutation_p.S738R|GRM1_uc003qll.2_Missense_Mutation_p.S738R|GRM1_uc011edz.1_Missense_Mutation_p.S738R|GRM1_uc011eea.1_Missense_Mutation_p.S738R	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	738	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCTACCCAAGTATCAAGGAAG	0.493													46	70					0	0	0	0	A	146720389	A	A	146720389	3	1	86	1	0	0	0	0	1	0	0	0	6835	1635	57	5	2240	5	GRM1	6	146720389	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	18416301	146720389	24394678	74	17173											
LRP11	84918	broad.mit.edu	37	chr6	150184555	150184555	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcgcttaccctgccggggcGaggcgcgcgcggtggccagg	3	4	19	15	8	0	0	0	0	0	0	0	1	0	0	3	6	2	1	3	6	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:150184555G>A	uc003qng.2	-	1	926	c.602C>T	c.(601-603)TCG>TTG	p.S201L	uc003qni.1_5'Flank|LRP11_uc003qnh.1_Missense_Mutation_p.S201L	NM_032832	NP_116221	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein	201	Extracellular (Potential).					integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		CTgccggggcgaggcgcgcgc	0.502													8	15					0	0	0	0	A	150184555	A	A	150184555	3	1	86	1	0	0	0	0	1	0	0	0	9003	1059	37	1	928	1	LRP11	6	150184555	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	3464166	150184555	20930512	75	17174											
MTHFD1L	25902	broad.mit.edu	37	chr6	151239718	151239718	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccaattttttacagggaagGttgggtgtggctctccaaga	9	13	12	7	0	1	1	0	0	1	1	3	2	2	2	2	4	1	2	2	4	4	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:151239718G>A	uc003qob.2	+	9	1166	c.898G>A	c.(898-900)GTT>ATT	p.V300I	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Missense_Mutation_p.V301I|MTHFD1L_uc003qoc.2_Missense_Mutation_p.V248I	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	300	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		TACAGGGAAGGTTGGGTGTGG	0.413													28	42					0	0	0	0	A	151239718	A	A	151239718	3	1	86	1	0	0	0	0	1	0	0	0	9981	1261	44	4	932	4	MTHFD1L	6	151239718	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1055163	151239718	19875349	76	17175											
C6orf118	168090	broad.mit.edu	37	chr6	165715503	165715503	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagggcctccttcatcctcGccaccttccctgcgggcggc	3	8	10	20	3	1	0	1	0	0	0	5	0	4	0	7	3	1	0	7	3	0	2	rs149637046	byFrequency	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:165715503G>T	uc003qum.3	-	2	344	c.308C>A	c.(307-309)GCG>GAG	p.A103E	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	103											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CTTCATCCTCGCCACCTTCCC	0.682													43	49					6.2361e-21	8.42279e-21	1	0	T	165715503	T	T	165715503	3	4	86	1	0	0	0	0	1	0	0	0	2333	1087	38	3	1133	3	C6orf118	6	165715503	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	14475785	165715503	5399564	77	17176											
PDE10A	10846	broad.mit.edu	37	chr6	165848755	165848755	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcttctactagcagtgttttCctggacttggccacataagc	8	14	8	11	0	2	0	0	0	2	0	3	1	3	1	2	2	3	2	2	2	3	7			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:165848755C>A	uc003qun.2	-	7	718	c.477G>T	c.(475-477)AGG>AGT	p.R159S	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.R89S|PDE10A_uc003quo.2_Missense_Mutation_p.R169S	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	159	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GCAGTGTTTTCCTGGACTTGG	0.458													11	60					0.000151284	0.000163892	1	0	A	165848755	A	A	165848755	3	1	86	1	0	0	0	0	1	0	0	0	11684	854	30	2	1930	2	PDE10A	6	165848755	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	133252	165848755	5266312	78	17177											
TCP10L2	401285	broad.mit.edu	37	chr6	167595389	167595389	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgccgctccctccagacaGgacatggggccctgacctgg	7	6	12	16	1	0	2	0	1	0	1	2	3	2	3	5	4	1	1	5	4	0	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr6:167595389G>A	uc010kkp.2	+	8	1178	c.1047G>A	c.(1045-1047)CAG>CAA	p.Q349Q		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	349											0						CCTCCAGACAGGACATGGGGC	0.517													18	8					0	0	0	0	A	167595389	A	A	167595389	2	1	86	1	0	0	0	0	0	0	0	1	15778	991	35	4		4	TCP10L2	6	167595389	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1746634	167595389	3519678	79	17178											
NXPH1	30010	broad.mit.edu	37	chr7	8791022	8791022	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaattgtagatcatggcaatGggacatttagtgtttatttc	12	16	9	4	0	1	1	1	0	0	1	2	2	1	2	0	2	0	3	0	2	5	7			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:8791022G>T	uc003srv.2	+	3	1350	c.439G>T	c.(439-441)GGG>TGG	p.G147W	NXPH1_uc011jxh.1_Missense_Mutation_p.G30W	NM_152745	NP_689958	P58417	NXPH1_HUMAN	neurexophilin 1 precursor	147	III.					extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		TCATGGCAATGGGACATTTAG	0.393													15	50					2.32078e-09	2.81745e-09	1	0	T	8791022	T	T	8791022	3	4	86	1	0	0	0	0	1	0	0	0	10844	1348	47	4	445	4	NXPH1	7	8791022	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08		8791022	150347641	80	17179											
SP4	6671	broad.mit.edu	37	chr7	21469118	21469118	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctccactcctcctgcttCaaaagagaataacgtttctc	10	12	5	14	1	2	1	1	0	1	1	6	2	5	1	4	0	3	2	4	0	4	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:21469118C>T	uc003sva.2	+	3	516	c.335C>T	c.(334-336)TCA>TTA	p.S112L	SP4_uc003svb.2_5'UTR	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	112					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						CCTCCTGCTTCAAAAGAGAAT	0.438													17	56					0	0	0	0	T	21469118	T	T	21469118	3	4	86	1	0	0	0	0	1	0	0	0	15030	838	29	2	345	2	SP4	7	21469118	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	12678096	21469118	137669545	81	17180											
GPR141	353345	broad.mit.edu	37	chr7	37780667	37780667	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caccaggagttctgggctcaGctgaaaaacctattttttat	11	13	8	9	0	2	1	1	1	1	0	2	2	2	2	2	2	2	3	2	2	4	5	rs145445554	byFrequency	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:37780667G>T	uc003tfm.1	+	1	672	c.672G>T	c.(670-672)CAG>CAT	p.Q224H	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	224	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						TCTGGGCTCAGCTGAAAAACC	0.438													43	110					2.35958e-20	3.17323e-20	1	0	T	37780667	T	T	37780667	3	4	86	1	0	0	0	0	1	0	0	0	6687	962	34	4	674	4	GPR141	7	37780667	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	16311549	37780667	121357996	82	17181											
COBL	23242	broad.mit.edu	37	chr7	51097136	51097136	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	attggaaaacaaccccgaatCcacaggatcatctgaaactt	16	8	6	11	1	2	1	1	1	1	0	3	4	3	3	3	2	3	0	3	2	5	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:51097136C>G	uc003tpr.3	-	10	1842	c.1657G>C	c.(1657-1659)GAT>CAT	p.D553H	COBL_uc003tps.2_Missense_Mutation_p.D610H|COBL_uc011kcl.1_Missense_Mutation_p.D553H|COBL_uc003tpp.3_Missense_Mutation_p.D339H|COBL_uc003tpq.3_Missense_Mutation_p.D494H|COBL_uc003tpo.3_Missense_Mutation_p.D95H	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	553										skin(3)|ovary(2)	5	Glioma(55;0.08)					AACCCCGAATCCACAGGATCA	0.527													22	55					0	0	0	0	G	51097136	G	G	51097136	3	3	86	1	0	0	0	0	1	0	0	0	3668	855	30	2	2144	2	COBL	7	51097136	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	13316469	51097136	108041527	83	17182											
ZNF679	168417	broad.mit.edu	37	chr7	63721218	63721218	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttaataaaacaggtattgCtgtctctaagccagacttga	13	13	7	8	0	2	2	0	1	2	1	3	2	2	2	1	1	3	2	1	1	5	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:63721218C>T	uc003tsx.2	+	4	442	c.173C>T	c.(172-174)GCT>GTT	p.A58V		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	58	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ACAGGTATTGCTGTCTCTAAG	0.333													14	49					0	0	0	0	T	63721218	T	T	63721218	3	4	86	1	0	0	0	0	1	0	0	0	18153	797	28	4	183	4	ZNF679	7	63721218	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	12624082	63721218	95417445	84	17183											
CLDN3	1365	broad.mit.edu	37	chr7	73183873	73183873	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccagcagctgcagcgccgcGgccgcccagcccacgtacag	7	2	12	20	5	0	0	0	0	0	0	0	0	0	0	5	1	6	4	5	1	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:73183873G>T	uc003tzg.3	-	1	728	c.507C>A	c.(505-507)GCC>GCA	p.A169A	RFC2_uc011kfa.1_Intron	NM_001306	NP_001297	O15551	CLD3_HUMAN	claudin 3	169	Helical; (Potential).				response to hypoxia	integral to plasma membrane|tight junction	structural molecule activity|transmembrane receptor activity				0		Lung NSC(55;0.159)				GCAGCGCCGCGGCCGCCCAGC	0.701													21	26					8.34094e-07	9.5325e-07	1	0	T	73183873	T	T	73183873	2	4	86	1	0	0	0	0	0	0	0	1	3501	1103	39	3		3	CLDN3	7	73183873	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	9462655	73183873	85954790	85	17184											
YWHAG	7532	broad.mit.edu	37	chr7	75988084	75988084	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgtagcgctccgcctgctcGgccagccgggctttctgcac	3	9	12	17	5	1	0	0	0	1	0	4	0	2	0	4	2	4	5	4	2	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:75988084G>T	uc011kgj.1	-	1	259	c.42C>A	c.(40-42)GCC>GCA	p.A14A		NM_012479	NP_036611	P61981	1433G_HUMAN	tyrosine 3-monooxygenase/tryptophan	14					G2/M transition of mitotic cell cycle|regulation of neuron differentiation|regulation of signal transduction|regulation of synaptic plasticity	cytosol	insulin-like growth factor receptor binding|protein kinase C binding|protein kinase C inhibitor activity			ovary(1)|lung(1)	2						CCGCCTGCTCGGCCAGCCGGG	0.697													17	40					6.94344e-10	8.56267e-10	1	0	T	75988084	T	T	75988084	2	4	86	1	0	0	0	0	0	0	0	1	17571	1103	39	3		3	YWHAG	7	75988084	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	2804211	75988084	83150579	86	17185											
UPK3B	80761	broad.mit.edu	37	chr7	76140092	76140092	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atggacgcgtccagccagacCcaaggggctgggggccctgc	7	4	16	14	2	0	1	0	0	0	1	1	2	1	2	4	5	2	1	4	5	1	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:76140092C>A	uc003ufq.2	+	1	348	c.123C>A	c.(121-123)ACC>ACA	p.T41T	UPK3B_uc003ufo.2_Intron|UPK3B_uc010ldk.1_Intron	NM_030570	NP_085047	Q9BT76	UPK3B_HUMAN	uroplakin 3B isoform a	41	Lumenal (Potential).				negative regulation of gene expression	integral to membrane|plasma membrane				central_nervous_system(1)	1		Myeloproliferative disorder(862;0.204)				CCAGCCAGACCCAAGGGGCTG	0.706													7	22					1.58986e-06	1.79724e-06	1	0	A	76140092	A	A	76140092	2	1	86	1	0	0	0	0	0	0	0	1	17079	610	22	4		4	UPK3B	7	76140092	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	152008	76140092	82998571	87	17186											
PCLO	27445	broad.mit.edu	37	chr7	82390032	82390032	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctctcgatcatgtctgcataCtcttgtttttttcttgatca	6	20	5	10	1	6	1	2	1	4	0	7	2	6	1	0	0	2	2	0	0	1	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:82390032C>A	uc003uhx.2	-	24	15500	c.15211G>T	c.(15211-15213)GTA>TTA	p.V5071L		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4994	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGTCTGCATACTCTTGTTTTT	0.333													9	36					1.12685e-05	1.25117e-05	1	0	A	82390032	A	A	82390032	3	1	86	1	0	0	0	0	1	0	0	0	11637	565	20	4	225	4	PCLO	7	82390032	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	6249940	82390032	76748631	88	17187											
PCLO	27445	broad.mit.edu	37	chr7	82586052	82586052	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctaacttagccaaatctgagGggctggaagggctgctttct	9	11	12	9	0	2	1	0	1	2	0	2	2	2	2	1	4	3	3	1	4	4	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:82586052G>T	uc003uhx.2	-	5	4506	c.4217C>A	c.(4216-4218)CCC>CAC	p.P1406H	PCLO_uc003uhv.2_Missense_Mutation_p.P1406H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1337					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CAAATCTGAGGGGCTGGAAGG	0.398													16	59					1.02788e-11	1.30366e-11	1	0	T	82586052	T	T	82586052	3	4	86	1	0	0	0	0	1	0	0	0	11637	1232	43	4	11312	4	PCLO	7	82586052	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	196020	82586052	76552611	89	17188											
SEMA3E	9723	broad.mit.edu	37	chr7	82996904	82996904	+	Nonstop_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagatagtctcaccccatcAggagtccagcgtgtgcctgg	8	9	12	12	1	2	1	2	0	1	1	4	2	3	2	4	2	2	1	4	2	2	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:82996904A>G	uc003uhy.1	-	17	2792	c.2326T>C	c.(2326-2328)TGA>CGA	p.*776R		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	776					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TCACCCCATCAGGAGTCCAGC	0.408													5	244					0	0	0	0	G	82996904	G	G	82996904	4	3	86	1	0	0	0	0	0	0	0	0	14093	201	7	5	5	5	SEMA3E	7	82996904	Nonstop_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	410852	82996904	76141759	90	17189											
PON3	5446	broad.mit.edu	37	chr7	94996731	94996731	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagagaacgttgttgttccTcaaatttaaatatctccaca	13	13	5	10	1	2	1	1	0	1	1	4	2	3	1	3	0	1	3	3	0	5	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:94996731T>C	uc003unt.2	-	5	462	c.437A>G	c.(436-438)GAG>GGG	p.E146G	PON1_uc011kih.1_Intron|PON3_uc011kii.1_Missense_Mutation_p.E194G	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	146					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TTGTTGTTCCTCAAATTTAAA	0.348													3	132					0	0	0	0	C	94996731	C	C	94996731	3	2	86	1	0	0	0	0	1	0	0	0	12305	1551	54	5	647	5	PON3	7	94996731	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	11999827	94996731	64141932	91	17190											
RNF133	168433	broad.mit.edu	37	chr7	122338423	122338423	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagtgattcatccagatgaTgtgctttctccccacctcaa	10	13	6	12	0	3	3	2	2	1	1	5	3	4	3	4	0	1	1	4	0	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:122338423T>C	uc003vkj.1	-	1	786	c.550A>G	c.(550-552)ATC>GTC	p.I184V	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	184						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						ATCCAGATGATGTGCTTTCTC	0.378													28	73					0	0	0	0	C	122338423	C	C	122338423	3	2	86	1	0	0	0	0	1	0	0	0	13504	1464	51	5	584	5	RNF133	7	122338423	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	27341692	122338423	36800240	92	17191											
NUP205	23165	broad.mit.edu	37	chr7	135304382	135304382	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agtgggttttgcttctattgGagattcttcactttacatca	8	18	8	7	0	4	1	2	0	2	1	4	2	4	1	0	2	2	2	0	2	2	9			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:135304382G>T	uc003vsw.2	+	29	4206	c.4175G>T	c.(4174-4176)GGA>GTA	p.G1392V	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1392					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GCTTCTATTGGAGATTCTTCA	0.363													7	27					8.12818e-05	8.83621e-05	1	0	T	135304382	T	T	135304382	3	4	86	1	0	0	0	0	1	0	0	0	10813	1174	41	2	4289	2	NUP205	7	135304382	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	12965959	135304382	23834281	93	17192											
DGKI	9162	broad.mit.edu	37	chr7	137148266	137148266	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtggctgagatctttcaGatctgagtcctcataatagg	10	12	12	7	0	4	3	2	2	2	2	5	5	5	4	1	3	0	1	1	3	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:137148266G>T	uc003vtt.2	-	28	2729	c.2728C>A	c.(2728-2730)CTG>ATG	p.L910M	DGKI_uc003vtu.2_Intron	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	910					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						AGATCTTTCAGATCTGAGTCC	0.522													21	42					1.01871e-10	1.27646e-10	1	0	T	137148266	T	T	137148266	3	4	86	1	0	0	0	0	1	0	0	0	4493	933	33	2	497	2	DGKI	7	137148266	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1843884	137148266	21990397	94	17193											
ZNF425	155054	broad.mit.edu	37	chr7	148801945	148801945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttcatgcccctcttcaggcGgaagcaccggtcacactgcg	7	8	10	16	3	4	0	3	0	1	0	4	1	4	1	3	3	3	1	3	3	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:148801945G>A	uc003wfj.2	-	4	1091	c.1018C>T	c.(1018-1020)CGC>TGC	p.R340C		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	340	C2H2-type 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTCTTCAGGCGGAAGCACCGG	0.662													10	45					0	0	0	0	A	148801945	A	A	148801945	3	1	86	1	0	0	0	0	1	0	0	0	17966	1116	39	1	1244	1	ZNF425	7	148801945	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	11653679	148801945	10336718	95	17194											
SMARCD3	6604	broad.mit.edu	37	chr7	150939293	150939293	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaactcttgaagaaagaaGagaacttccgcttctgtttg	13	11	8	9	1	2	4	0	1	2	3	3	5	3	4	2	0	2	2	2	0	5	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr7:150939293G>A	uc003wjs.2	-	6	706	c.605C>T	c.(604-606)TCT>TTT	p.S202F	SMARCD3_uc003wjt.2_Missense_Mutation_p.S189F|SMARCD3_uc003wju.2_Missense_Mutation_p.S189F|SMARCD3_uc011kvh.1_Missense_Mutation_p.S202F|SMARCD3_uc010lqa.1_Missense_Mutation_p.S202F	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	202					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAAGAAAGAAGAGAACTTCCG	0.547													24	130					0	0	0	0	A	150939293	A	A	150939293	3	1	86	1	0	0	0	0	1	0	0	0	14843	942	33	2	878	2	SMARCD3	7	150939293	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	2137348	150939293	8199370	96	17195											
SCARA5	286133	broad.mit.edu	37	chr8	27779353	27779353	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacgtcggccagctcctcGcccaggatgcccaccctgcg	5	5	10	21	4	0	0	0	0	0	0	3	1	1	1	6	2	3	1	6	2	0	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:27779353G>A	uc003xgj.2	-	4	1091	c.651C>T	c.(649-651)GGC>GGT	p.G217G	SCARA5_uc010luz.2_Intron|SCARA5_uc003xgk.2_Silent_p.G174G|SCARA5_uc003xgl.2_Silent_p.G217G	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	217	Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CCAGCTCCTCGCCCAGGATGC	0.721													4	3					0	0	0	0	A	27779353	A	A	27779353	2	1	86	1	0	0	0	0	0	0	0	1	13945	1074	38	1		1	SCARA5	8	27779353	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08		27779353	118584669	97	17196											
GSR	2936	broad.mit.edu	37	chr8	30546804	30546804	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtaaccatgctgacttcCaagcccgacaaagtcttttt	11	11	7	12	1	1	1	0	1	1	0	2	2	2	1	3	0	3	3	3	0	3	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:30546804C>T	uc003xih.1	-	9	1006	c.915G>A	c.(913-915)TTG>TTA	p.L305L		NM_000637	NP_000628	P00390	GSHR_HUMAN	glutathione reductase precursor	305					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			ovary(2)|pancreas(2)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TGCTGACTTCCAAGCCCGACA	0.502													27	27					0	0	0	0	T	30546804	T	T	30546804	2	4	86	1	0	0	0	0	0	0	0	1	6867	593	21	4		4	GSR	8	30546804	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	2767451	30546804	115817218	98	17197											
PRDM14	63978	broad.mit.edu	37	chr8	70970925	70970925	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagaatgtggatccgaagccGgtcccgcttctcaaaggatc	11	8	11	11	3	1	1	1	0	1	1	5	4	3	3	3	3	1	1	3	3	4	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:70970925G>C	uc003xym.2	-	6	1538	c.1336C>G	c.(1336-1338)CGG>GGG	p.R446G		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	446	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			ATCCGAAGCCGGTCCCGCTTC	0.502													28	64					0	0	0	0	C	70970925	C	C	70970925	3	2	86	1	0	0	0	0	1	0	0	0	12517	1115	39	3	391	3	PRDM14	8	70970925	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	40424121	70970925	75393097	99	17198											
KCNB2	9312	broad.mit.edu	37	chr8	73849954	73849954	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagggctgtcccccaggttTcccaagcagaaactgttccc	10	8	9	14	0	0	1	0	0	0	1	3	1	3	1	4	2	2	4	4	2	3	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:73849954T>A	uc003xzb.2	+	3	2952	c.2364T>A	c.(2362-2364)TTT>TTA	p.F788L		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	788	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CCCCCAGGTTTCCCAAGCAGA	0.537													21	78					0	0	0	0	A	73849954	A	A	73849954	3	1	86	1	0	0	0	0	1	0	0	0	8052	1780	62	5	2370	5	KCNB2	8	73849954	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	2879029	73849954	72514068	100	17199											
FAM135B	51059	broad.mit.edu	37	chr8	139164289	139164289	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacaaagttgagagcaagatCctggggaaccttggctcttg	11	9	12	9	0	1	2	0	1	1	2	2	4	2	3	2	3	2	3	2	3	3	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:139164289C>A	uc003yuy.2	-	13	2600	c.2429G>T	c.(2428-2430)GGA>GTA	p.G810V	FAM135B_uc003yux.2_Missense_Mutation_p.G711V|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.G372V|FAM135B_uc003yvb.2_Missense_Mutation_p.G372V	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	810										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGAGCAAGATCCTGGGGAACC	0.537										HNSCC(54;0.14)			15	99					0.000219431	0.000236895	1	0	A	139164289	A	A	139164289	3	1	86	1	0	0	0	0	1	0	0	0	5477	855	30	2	1823	2	FAM135B	8	139164289	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	65314335	139164289	7199733	101	17200											
EIF2C2	27161	broad.mit.edu	37	chr8	141568597	141568597	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgttacgtttggtgactggCgggccgccgggtcacattgc	4	11	16	10	4	1	1	1	1	0	0	1	1	1	1	2	4	2	2	2	4	1	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr8:141568597C>A	uc003yvn.2	-	7	905	c.865G>T	c.(865-867)GCC>TCC	p.A289S	EIF2C2_uc010men.2_Missense_Mutation_p.A212S|EIF2C2_uc010meo.2_Missense_Mutation_p.A289S	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	289	PAZ.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			TGGTGACTGGCGGGCCGCCGG	0.597													65	84					9.65139e-37	1.3813e-36	1	0	A	141568597	A	A	141568597	3	1	86	1	0	0	0	0	1	0	0	0	5028	768	27	3	1766	3	EIF2C2	8	141568597	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	2404308	141568597	4795425	102	17201											
KIAA2026	158358	broad.mit.edu	37	chr9	6007399	6007399	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccctgtccgggctgctgcGggaaggcgcgaccgccccgg	3	5	17	16	6	0	0	0	0	0	0	1	2	1	1	5	4	3	2	5	4	1	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:6007399G>A	uc003zjq.3	-	1	605	c.389C>T	c.(388-390)CCG>CTG	p.P130L		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	130										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		GGGCTGCTGCGGGAAGGCGCG	0.706													24	19					0	0	0	0	A	6007399	A	A	6007399	3	1	86	1	0	0	0	0	1	0	0	0	8309	1116	39	1	5954	1	KIAA2026	9	6007399	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08		6007399	135206032	103	17202											
SIGMAR1	10280	broad.mit.edu	37	chr9	34635731	34635731	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaagtcctgggtgctgaaGacagtgtcggccagcgcgaa	10	6	16	9	3	0	2	0	1	0	1	2	4	1	3	2	3	2	1	2	3	3	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:34635731G>C	uc003zvb.2	-	4	644	c.570C>G	c.(568-570)GTC>GTG	p.V190V	SIGMAR1_uc003zva.3_Silent_p.V170V|SIGMAR1_uc003zuz.2_Silent_p.V101V|SIGMAR1_uc003zvc.2_Silent_p.V159V|SIGMAR1_uc003zvd.2_RNA|SIGMAR1_uc011loo.1_Intron	NM_005866	NP_005857	Q99720	SGMR1_HUMAN	sigma non-opioid intracellular receptor 1	190	Cytoplasmic (Potential).				ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding				0					Dextromethorphan(DB00514)	GGGTGCTGAAGACAGTGTCGG	0.617													43	35					0	0	0	0	C	34635731	C	C	34635731	2	2	86	1	0	0	0	0	0	0	0	1	14381	929	33	2		2	SIGMAR1	9	34635731	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	28628332	34635731	106577700	104	17203											
ZNF658	26149	broad.mit.edu	37	chr9	40772546	40772546	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcccacattcactgcattcaTagggtttctcccctgagcga	8	12	7	14	1	3	1	2	1	1	0	5	2	4	1	3	1	2	2	3	1	1	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:40772546T>C	uc004abs.2	-	5	2881	c.2729A>G	c.(2728-2730)TAT>TGT	p.Y910C	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.Y910C	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	910	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACTGCATTCATAGGGTTTCTC	0.443													139	120					0	0	0	0	C	40772546	C	C	40772546	3	2	86	1	0	0	0	0	1	0	0	0	18136	1406	49	5	454	5	ZNF658	9	40772546	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	6136815	40772546	100440885	105	17204											
RASEF	158158	broad.mit.edu	37	chr9	85616027	85616027	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcacagtcctcatccacAtaggaagagcgggatgacct	12	7	11	11	1	2	2	2	1	0	1	4	5	4	4	3	2	1	0	3	2	2	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:85616027A>T	uc004amo.1	-	10	1482	c.1221T>A	c.(1219-1221)TAT>TAA	p.Y407*		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	407					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						CCTCATCCACATAGGAAGAGC	0.502													9	34					0	0	0	0	T	85616027	T	T	85616027	4	4	86	1	0	0	0	0	0	1	0	0	13133	224	8	5	1033	5	RASEF	9	85616027	Nonsense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	44843481	85616027	55597404	106	17205											
IARS	3376	broad.mit.edu	37	chr9	95027219	95027219	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggaggcataccatcctctGgtttggtcgatgccctcggc	7	10	12	12	2	1	0	0	0	1	0	4	2	2	1	3	5	2	2	3	5	2	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:95027219G>C	uc004art.1	-	16	1949	c.1692C>G	c.(1690-1692)ACC>ACG	p.T564T	IARS_uc004ars.1_Silent_p.T409T|IARS_uc004aru.3_Silent_p.T564T|IARS_uc010mqr.2_Silent_p.T454T|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	564					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	ACCATCCTCTGGTTTGGTCGA	0.398													9	35					0	0	0	0	C	95027219	C	C	95027219	2	2	86	1	0	0	0	0	0	0	0	1	7512	1335	47	4		4	IARS	9	95027219	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	9411192	95027219	46186212	107	17206											
ECM2	1842	broad.mit.edu	37	chr9	95274325	95274325	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacctatgcctgaagaagTgatattatttttactcagat	12	15	8	6	0	1	4	1	2	0	2	1	5	1	5	2	1	2	0	2	1	6	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:95274325T>A	uc004ash.2	-	5	1203	c.1138A>T	c.(1138-1140)ACT>TCT	p.T380S	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Missense_Mutation_p.T358S|ECM2_uc011lty.1_Missense_Mutation_p.T380S|ECM2_uc004asg.2_Missense_Mutation_p.T358S	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	380	LRR 1.				cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						CCTGAAGAAGTGATATTATTT	0.403													11	50					0	0	0	0	A	95274325	A	A	95274325	3	1	86	1	0	0	0	0	1	0	0	0	4920	1696	59	5	985	5	ECM2	9	95274325	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	247106	95274325	45939106	108	17207											
CERCAM	51148	broad.mit.edu	37	chr9	131193524	131193524	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaggacccttactcgggccGcactctgaccaagggcgagg	8	5	13	15	3	1	1	0	1	1	0	2	3	1	2	4	4	1	1	4	4	2	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr9:131193524G>A	uc004buz.3	+	9	1543	c.1145G>A	c.(1144-1146)CGC>CAC	p.R382H	CERCAM_uc004buy.1_Missense_Mutation_p.R304H|CERCAM_uc010mxz.2_Missense_Mutation_p.R304H|CERCAM_uc010mya.1_Missense_Mutation_p.R223H	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	382					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						TACTCGGGCCGCACTCTGACC	0.627													4	123					0	0	0	0	A	131193524	A	A	131193524	3	1	86	1	0	0	0	0	1	0	0	0	3281	1087	38	1	1179	1	CERCAM	9	131193524	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	35919199	131193524	10019907	109	17208											
ANKRD16	54522	broad.mit.edu	37	chr10	5929887	5929887	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacagtgagcaggtactggAggatcagagggtcgccttct	11	8	14	8	1	2	2	1	1	1	1	3	4	2	4	1	4	3	2	1	4	2	2	rs112121948		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:5929887A>G	uc010qat.1	-	2	1001	c.458T>C	c.(457-459)CTC>CCC	p.L153P	ANKRD16_uc009xie.2_Missense_Mutation_p.L153P|ANKRD16_uc009xif.2_Missense_Mutation_p.L153P|ANKRD16_uc001iiq.2_Missense_Mutation_p.L153P|FBXO18_uc001iir.2_5'Flank|FBXO18_uc001iis.2_5'Flank|FBXO18_uc009xig.2_5'Flank	NM_019046	NP_061919	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16 isoform a	153	ANK 4.										0						CAGGTACTGGAGGATCAGAGG	0.532													13	54					0	0	0	0	G	5929887	G	G	5929887	3	3	86	1	0	0	0	0	1	0	0	0	645	304	11	5	651	5	ANKRD16	10	5929887	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08		5929887	129604860	110	17209											
ARMC4	55130	broad.mit.edu	37	chr10	28151364	28151364	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaaagatgtgttacttactGtatttgccagtttggacaat	13	15	8	5	0	0	1	0	0	0	1	0	2	0	2	1	1	3	3	1	1	6	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:28151364G>C	uc009xky.2	-	18	2896	c.2798C>G	c.(2797-2799)ACA>AGA	p.T933R	ARMC4_uc010qds.1_Missense_Mutation_p.T458R|ARMC4_uc010qdt.1_Missense_Mutation_p.T625R|ARMC4_uc001itz.2_Missense_Mutation_p.T933R	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	933	ARM 8.						binding			ovary(4)|skin(2)	6						GTTACTTACTGTATTTGCCAG	0.244													16	36					0	0	0	0	C	28151364	C	C	28151364	3	2	86	1	0	0	0	0	1	0	0	0	955	1391	48	4	348	4	ARMC4	10	28151364	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	22221477	28151364	107383383	111	17210											
KIAA1462	57608	broad.mit.edu	37	chr10	30317109	30317109	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatttgtttgtctgtcttcTtctggttcccctagatcttg	3	21	7	10	0	6	1	1	0	5	1	7	1	7	1	2	1	0	2	2	1	1	7			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:30317109T>A	uc001iux.2	-	2	2027	c.1968A>T	c.(1966-1968)GAA>GAT	p.E656D	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.E518D|KIAA1462_uc009xle.1_Missense_Mutation_p.E656D	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	656										ovary(4)	4						GTCTGTCTTCTTCTGGTTCCC	0.522													11	47					0	0	0	0	A	30317109	A	A	30317109	3	1	86	1	0	0	0	0	1	0	0	0	8273	1606	56	5	2119	5	KIAA1462	10	30317109	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	2165745	30317109	105217638	112	17211											
EGR2	1959	broad.mit.edu	37	chr10	64575770	64575770	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagttactgggattttgtctAcggccttggcggtcatcatt	6	15	12	8	2	3	0	2	0	1	0	3	2	3	1	1	4	2	1	1	4	2	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:64575770A>G	uc010qim.1	-	2	174	c.20T>C	c.(19-21)GTA>GCA	p.V7A	EGR2_uc010qin.1_Intron|EGR2_uc001jmi.2_Missense_Mutation_p.V7A|EGR2_uc010qio.1_Intron|EGR2_uc009xph.2_Missense_Mutation_p.V7A	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	7					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GATTTTGTCTACGGCCTTGGC	0.562													72	90					0	0	0	0	G	64575770	G	G	64575770	3	3	86	1	0	0	0	0	1	0	0	0	4994	391	14	5	1418	5	EGR2	10	64575770	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	34258661	64575770	70958977	113	17212											
JMJD1C	221037	broad.mit.edu	37	chr10	64974163	64974163	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctctttttccatgttcaaGtgatcatttcctgaagaagc	9	17	6	9	0	3	3	2	2	1	1	6	3	5	3	2	0	1	1	2	0	3	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:64974163G>C	uc001jmn.2	-	8	2064	c.1764C>G	c.(1762-1764)CAC>CAG	p.H588Q	JMJD1C_uc001jml.2_Missense_Mutation_p.H369Q|JMJD1C_uc001jmm.2_Missense_Mutation_p.H300Q|JMJD1C_uc010qiq.1_Missense_Mutation_p.H406Q|JMJD1C_uc009xpi.2_Missense_Mutation_p.H406Q|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_Missense_Mutation_p.H300Q	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	588					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CCATGTTCAAGTGATCATTTC	0.393													5	35					0	0	0	0	C	64974163	C	C	64974163	3	2	86	1	0	0	0	0	1	0	0	0	7989	1020	36	4	5934	4	JMJD1C	10	64974163	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	398393	64974163	70560584	114	17213											
PLCE1	51196	broad.mit.edu	37	chr10	95791986	95791986	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaagatgggagccaacgtCtgtcagaagcccagtggtat	11	7	14	9	1	2	2	1	0	1	2	2	3	2	3	2	3	3	2	2	3	4	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:95791986C>T	uc001kjk.2	+	2	1817	c.1183C>T	c.(1183-1185)CTG>TTG	p.L395L	PLCE1_uc010qnx.1_Silent_p.L395L	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	395					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GAGCCAACGTCTGTCAGAAGC	0.408													5	37					0	0	0	0	T	95791986	T	T	95791986	2	4	86	1	0	0	0	0	0	0	0	1	12089	912	32	2		2	PLCE1	10	95791986	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	30817823	95791986	39742761	115	17214											
CC2D2B	387707	broad.mit.edu	37	chr10	97769618	97769618	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctgtagtggtcactcatatAtaagaaagaattggcttgga	13	12	11	5	0	2	2	2	0	0	2	2	3	2	3	0	3	0	3	0	3	6	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:97769618A>G	uc001kll.2	+	3	257	c.58A>G	c.(58-60)ATA>GTA	p.I20V	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_RNA|CC2D2B_uc010qop.1_Missense_Mutation_p.I20V	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	20										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		TCACTCATATATAAGAAAGAA	0.318													4	30					0	0	0	0	G	97769618	G	G	97769618	3	3	86	1	0	0	0	0	1	0	0	0	2741	449	16	5	64	5	CC2D2B	10	97769618	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	1977632	97769618	37765129	116	17215											
ABCC2	1244	broad.mit.edu	37	chr10	101578649	101578649	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgaccccctgtctgcagtgGatgctcatgtaggaaaacat	11	10	10	10	0	2	1	1	1	1	0	2	3	2	3	2	2	3	3	2	2	3	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:101578649G>T	uc001kqf.2	+	18	2513	c.2374G>T	c.(2374-2376)GAT>TAT	p.D792Y		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	792	Cytoplasmic (By similarity).|ABC transporter 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTCTGCAGTGGATGCTCATGT	0.433													30	22					4.43304e-23	6.11994e-23	1	0	T	101578649	T	T	101578649	3	4	86	1	0	0	0	0	1	0	0	0	53	1174	41	2	2444	2	ABCC2	10	101578649	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	3809031	101578649	33956098	117	17216											
PAX2	5076	broad.mit.edu	37	chr10	102584502	102584502	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaccctggcaggaatggtGcctggtaggtgacaatgctg	8	9	14	10	0	0	1	0	1	0	0	1	2	1	2	3	5	2	3	3	5	3	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:102584502G>A	uc001krk.3	+	9	1636	c.1086G>A	c.(1084-1086)GTG>GTA	p.V362V	PAX2_uc001krl.3_Silent_p.V339V|PAX2_uc001krm.3_Silent_p.V362V|PAX2_uc001kro.3_Silent_p.V339V|PAX2_uc001krn.3_Silent_p.V339V|PAX2_uc010qps.1_Silent_p.V338V|PAX2_uc001krp.1_Silent_p.V335V	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	362					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		CAGGAATGGTGCCTGGTAGGT	0.617													21	99					0	0	0	0	A	102584502	A	A	102584502	2	1	86	1	0	0	0	0	0	0	0	1	11533	1306	46	4		4	PAX2	10	102584502	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1005853	102584502	32950245	118	17217											
POLL	27343	broad.mit.edu	37	chr10	103342623	103342623	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtcagggaggcctggctgCggatgtcttccagacttcgg	5	11	15	10	2	2	1	1	0	1	1	4	3	3	3	2	5	1	1	2	5	0	3	rs146112511		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:103342623C>A	uc001ktg.1	-	6	1857	c.1091G>T	c.(1090-1092)CGC>CTC	p.R364L	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_Missense_Mutation_p.R37L|POLL_uc001kte.1_Missense_Mutation_p.R56L|POLL_uc001kth.1_Missense_Mutation_p.R89L|POLL_uc001kti.1_Missense_Mutation_p.R364L|POLL_uc001ktj.1_Missense_Mutation_p.R364L|POLL_uc001ktf.2_Missense_Mutation_p.R272L|POLL_uc001ktk.1_Missense_Mutation_p.R103L|POLL_uc010qqa.1_Missense_Mutation_p.R103L|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Missense_Mutation_p.R364L|POLL_uc001ktl.2_Missense_Mutation_p.R276L|POLL_uc010qqc.1_Missense_Mutation_p.R56L	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	364					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GGCCTGGCTGCGGATGTCTTC	0.552								DNA_polymerases_(catalytic_subunits)					14	89					3.27435e-08	3.91417e-08	1	0	A	103342623	A	A	103342623	3	1	86	1	0	0	0	0	1	0	0	0	12260	768	27	3	648	3	POLL	10	103342623	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	758121	103342623	32192124	119	17218											
GBF1	8729	broad.mit.edu	37	chr10	104018750	104018750	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agattaacattgtggttgggGccatcaaacgaaatgcccga	13	9	11	8	2	1	1	1	0	0	1	1	3	1	1	2	3	3	1	2	3	3	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:104018750G>A	uc001kux.1	+	2	295	c.55G>A	c.(55-57)GCC>ACC	p.A19T	GBF1_uc001kuw.2_Missense_Mutation_p.A19T|GBF1_uc001kuy.1_Missense_Mutation_p.A19T|GBF1_uc001kuz.1_Missense_Mutation_p.A19T	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	19					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		TGTGGTTGGGGCCATCAAACG	0.408													19	138					0	0	0	0	A	104018750	A	A	104018750	3	1	86	1	0	0	0	0	1	0	0	0	6306	1203	42	4	57	4	GBF1	10	104018750	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	676127	104018750	31515997	120	17219											
GFRA1	2674	broad.mit.edu	37	chr10	117849257	117849257	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggacgcagttctcacctgtaAatttgcacacggtggcaaaa	12	9	10	10	2	1	0	1	0	1	0	2	1	1	1	1	3	1	5	1	3	4	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:117849257A>T	uc001lcj.2	-	9	1890	c.1192T>A	c.(1192-1194)TTA>ATA	p.L398I	GFRA1_uc001lci.2_Missense_Mutation_p.L393I|GFRA1_uc009xyr.2_Missense_Mutation_p.L393I	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	398					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTCACCTGTAAATTTGCACAC	0.547													19	126					0	0	0	0	T	117849257	T	T	117849257	3	4	86	1	0	0	0	0	1	0	0	0	6384	11	1	5	217	5	GFRA1	10	117849257	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	13830507	117849257	17685490	121	17220											
KCNK18	338567	broad.mit.edu	37	chr10	118957108	118957108	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggtgacctacgccctggtgGgtgctgtggtcttctctgcc	2	13	14	12	1	2	1	0	1	2	0	3	1	2	1	3	4	3	1	3	4	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:118957108G>T	uc010qsr.1	+	1	109	c.109G>T	c.(109-111)GGT>TGT	p.G37C		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	37	Helical; (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CGCCCTGGTGGGTGCTGTGGT	0.597													29	27					9.39395e-14	1.22121e-13	1	0	T	118957108	T	T	118957108	3	4	86	1	0	0	0	0	1	0	0	0	8104	1232	43	4	111	4	KCNK18	10	118957108	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1107851	118957108	16577639	122	17221											
PWWP2B	170394	broad.mit.edu	37	chr10	134218293	134218293	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttcagccccccgagaccAcccgccccgagccacccccg	6	2	10	23	4	1	1	1	0	0	1	1	3	1	1	10	1	2	1	10	1	0	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:134218293A>C	uc001lll.3	+	2	318	c.289A>C	c.(289-291)ACC>CCC	p.T97P	PWWP2B_uc009ybe.2_Missense_Mutation_p.T97P	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	97	Pro-rich.										0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		CCCCGAGACCACCCGCCCCGA	0.756													6	17					0	0	0	0	C	134218293	C	C	134218293	3	2	86	1	0	0	0	0	1	0	0	0	12911	159	6	5	295	5	PWWP2B	10	134218293	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	15261185	134218293	1316454	123	17222											
INPP5A	3632	broad.mit.edu	37	chr10	134464009	134464009	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaatcccaggagcacttcacGgtgagtccctcccgctgcct	8	8	9	16	2	1	1	1	1	0	0	4	2	4	2	4	2	2	2	4	2	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:134464009G>T	uc001llp.2	+	4	554	c.306G>T	c.(304-306)ACG>ACT	p.T102T	INPP5A_uc001llo.1_Silent_p.T102T|INPP5A_uc001llq.2_Silent_p.T54T	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	102					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		AGCACTTCACGGTGAGTCCCT	0.542													62	70					3.74213e-36	5.33125e-36	1	0	T	134464009	T	T	134464009	2	4	86	1	0	0	0	0	0	0	0	1	7793	1130	39	3		3	INPP5A	10	134464009	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	245716	134464009	1070738	124	17223											
CYP2E1	1571	broad.mit.edu	37	chr10	135346244	135346244	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actacttgcctggaagccacAgaaaagtcataaaaaatgtg	17	8	8	8	0	1	1	1	0	0	1	1	2	1	2	2	1	3	0	2	1	7	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr10:135346244A>T	uc001lnj.1	+	5	730	c.697A>T	c.(697-699)AGA>TGA	p.R233*	CYP2E1_uc001lnk.1_Nonsense_Mutation_p.R96*|CYP2E1_uc009ybl.1_Nonsense_Mutation_p.R34*|CYP2E1_uc009ybm.1_5'UTR|CYP2E1_uc001lnl.1_Nonsense_Mutation_p.R34*	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	233					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	TGGAAGCCACAGAAAAGTCAT	0.408									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				26	174					0	0	0	0	T	135346244	T	T	135346244	4	4	86	1	0	0	0	0	0	1	0	0	4187	180	7	5	715	5	CYP2E1	10	135346244	Nonsense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	882235	135346244	188503	125	17224											
MOB2	81532	broad.mit.edu	37	chr11	1491670	1491670	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagcacgtggaacaggtgtCtgcagatcttcctcaccagg	9	8	11	13	1	3	1	1	0	2	1	4	2	4	2	3	3	3	2	3	3	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:1491670C>G	uc010qwz.1	-	5	729	c.539G>C	c.(538-540)AGA>ACA	p.R180T	MOB2_uc001lto.1_Missense_Mutation_p.R64T|MOB2_uc001ltp.1_5'UTR|MOB2_uc001ltq.1_Missense_Mutation_p.R143T|MOB2_uc010qwy.1_Missense_Mutation_p.R64T	NM_053005	NP_443731	Q70IA6	MOB2_HUMAN	HCCA2 protein	149						nucleus|perinuclear region of cytoplasm	metal ion binding				0						GAACAGGTGTCTGCAGATCTT	0.587													27	54					0	0	0	0	G	1491670	G	G	1491670	3	3	86	1	0	0	0	0	1	0	0	0	9734	913	32	2	271	2	MOB2	11	1491670	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08		1491670	133514846	126	17225											
OR52E2	119678	broad.mit.edu	37	chr11	5080588	5080588	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcaaagatgatccctctgagGttgatccagaagattccaag	13	10	9	9	0	2	6	1	3	1	3	5	6	5	6	3	1	0	1	3	1	3	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:5080588G>T	uc010qyw.1	-	1	270	c.270C>A	c.(268-270)AAC>AAA	p.N90K		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		TCCCTCTGAGGTTGATCCAGA	0.483													15	25					2.31682e-05	2.54524e-05	1	0	T	5080588	T	T	5080588	3	4	86	1	0	0	0	0	1	0	0	0	11169	1252	44	4	710	4	OR52E2	11	5080588	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	3588918	5080588	129925928	127	17226											
INSC	387755	broad.mit.edu	37	chr11	15197593	15197601	+	In_Frame_Del	DEL	CAGTGCTGT	-	-																															cgctccatggtcagcgagtaCagtgctgtcagcaggaactc																								rs61745109		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:15197593_15197601delCAGTGCTGT	uc001mly.2	+	3	550_558	c.504_512delCAGTGCTGT	c.(502-513)TACAGTGCTGTC>TAC	p.SAV169del	INSC_uc001mlz.2_In_Frame_Del_p.SAV122del|INSC_uc001mma.2_In_Frame_Del_p.SAV122del|INSC_uc010rcs.1_In_Frame_Del_p.SAV122del|INSC_uc001mmb.2_In_Frame_Del_p.SAV122del|INSC_uc001mmc.2_In_Frame_Del_p.SAV122del	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	169_171					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						TCAGCGAGTACAGTGCTGTCAGCAGGAAC	0.612													---	---	---								-	15197601	-	-	15197593	7	5	86	1	0	1	0	1	0	0	0	0	7803	489	17	0	514	0	INSC	11	15197593	In_Frame_Del	DEL	CAGTGCTGT	TCGA-CN-6995-01A-31D-2012-08	10117005	15197593	119808923	128	17227											
SLC5A12	159963	broad.mit.edu	37	chr11	26695058	26695058	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taattaacagtggttgaataTcctcacctctttggcgacct	10	14	7	10	1	2	1	1	1	1	0	3	2	3	1	3	2	1	1	3	2	4	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:26695058T>G	uc001mra.2	-	14	1911	c.1598A>C	c.(1597-1599)GAT>GCT	p.D533A	SLC5A12_uc001mrb.2_RNA	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	533	Cytoplasmic (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						TGGTTGAATATCCTCACCTCT	0.373													13	103					0	0	0	0	G	26695058	G	G	26695058	3	3	86	1	0	0	0	0	1	0	0	0	14728	1435	50	5	266	5	SLC5A12	11	26695058	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	11497465	26695058	108311458	129	17228											
EXT2	2132	broad.mit.edu	37	chr11	44228424	44228424	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagtaaccgtttcttcccttAtgatgaaatcgagacagaag	14	11	8	8	2	1	4	0	2	1	2	3	5	2	4	2	0	1	2	2	0	5	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:44228424A>G	uc001mxz.2	+	10	1911	c.1577A>G	c.(1576-1578)TAT>TGT	p.Y526C	EXT2_uc010rfo.1_Missense_Mutation_p.Y554C|EXT2_uc001mxy.2_Missense_Mutation_p.Y539C|EXT2_uc009ykt.2_Missense_Mutation_p.Y536C|EXT2_uc001mya.2_Missense_Mutation_p.Y559C	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	526	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						TTCTTCCCTTATGATGAAATC	0.413			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				28	52					0	0	0	0	G	44228424	G	G	44228424	3	3	86	1	0	0	0	0	1	0	0	0	5349	449	16	5	1811	5	EXT2	11	44228424	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	17533366	44228424	90778092	130	17229											
CHST1	8534	broad.mit.edu	37	chr11	45672189	45672189	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatgagcgtgttctggacGtggtagaggggctcaaacag	9	8	18	6	2	2	2	1	1	1	1	2	4	2	4	0	5	2	3	0	5	2	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:45672189G>A	uc001mys.1	-	4	956	c.285C>T	c.(283-285)CAC>CAT	p.H95H		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	95	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		TGTTCTGGACGTGGTAGAGGG	0.657													30	72					0	0	0	0	A	45672189	A	A	45672189	2	1	86	1	0	0	0	0	0	0	0	1	3412	1136	40	1		1	CHST1	11	45672189	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1443765	45672189	89334327	131	17230											
CREB3L1	90993	broad.mit.edu	37	chr11	46332681	46332681	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccccctccagccctgtcAggcccatggcgcgctcctcc	3	7	9	22	2	1	0	1	0	0	0	4	0	4	0	8	2	2	1	8	2	0	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:46332681A>G	uc001ncf.2	+	5	1129	c.694A>G	c.(694-696)AGG>GGG	p.R232G		NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	232	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)		CAGCCCTGTCAGGCCCATGGC	0.667			T	FUS	myxofibrosarcoma								3	70					0	0	0	0	G	46332681	G	G	46332681	3	3	86	1	0	0	0	0	1	0	0	0	3871	179	7	5	712	5	CREB3L1	11	46332681	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	660492	46332681	88673835	132	17231											
MADD	8567	broad.mit.edu	37	chr11	47306595	47306595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaatcgaacgtggacagacGtcaggcagaaattggagagg	15	5	14	7	3	1	3	1	0	0	3	2	6	1	4	0	4	1	1	0	4	3	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:47306595G>A	uc001ner.1	+	13	2452	c.2261G>A	c.(2260-2262)CGT>CAT	p.R754H	MADD_uc001neq.2_Missense_Mutation_p.R754H|MADD_uc001nev.1_Missense_Mutation_p.R754H|MADD_uc001nes.1_Missense_Mutation_p.R754H|MADD_uc001net.1_Missense_Mutation_p.R754H|MADD_uc009yln.1_Missense_Mutation_p.R754H|MADD_uc001neu.1_Missense_Mutation_p.R754H|MADD_uc001nex.2_Missense_Mutation_p.R754H|MADD_uc001nez.2_Missense_Mutation_p.R754H|MADD_uc001new.2_Missense_Mutation_p.R754H	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	754					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		GTGGACAGACGTCAGGCAGAA	0.557													6	90					0	0	0	0	A	47306595	A	A	47306595	3	1	86	1	0	0	0	0	1	0	0	0	9203	1145	40	1	2307	1	MADD	11	47306595	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	973914	47306595	87699921	133	17232											
CLP1	10978	broad.mit.edu	37	chr11	57428484	57428484	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccctaaatctgggggtgTggtggagcgctccaaggact	7	9	15	10	1	1	0	0	0	1	0	3	2	3	2	2	5	1	2	2	5	3	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:57428484T>C	uc001nkw.2	+	3	993	c.854T>C	c.(853-855)GTG>GCG	p.V285A	CLP1_uc010rjw.1_Missense_Mutation_p.V221A|CLP1_uc009yml.2_Missense_Mutation_p.V285A	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	285					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1						TCTGGGGGTGTGGTGGAGCGC	0.512													3	144					0	0	0	0	C	57428484	C	C	57428484	3	2	86	1	0	0	0	0	1	0	0	0	3565	1696	59	5	860	5	CLP1	11	57428484	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	10121889	57428484	77578032	134	17233											
MPEG1	219972	broad.mit.edu	37	chr11	58979531	58979531	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaccctggagttggttcGgtttgagaggtagctcttgg	5	13	15	8	1	1	1	0	1	1	1	2	3	1	2	1	5	2	6	1	5	1	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:58979531G>A	uc001nnu.3	-	1	964	c.808C>T	c.(808-810)CGA>TGA	p.R270*		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	270	MACPF.|Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				GAGTTGGTTCGGTTTGAGAGG	0.532													4	16					0	0	0	0	A	58979531	A	A	58979531	4	1	86	1	0	0	0	0	0	1	0	0	9776	1124	39	1	1346	1	MPEG1	11	58979531	Nonsense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1551047	58979531	76026985	135	17234											
AHNAK	79026	broad.mit.edu	37	chr11	62293536	62293536	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcaggttcacgtccacatCtggaccttctcctttgaagc	7	11	10	13	1	3	1	1	1	2	0	5	2	4	2	3	3	1	2	3	3	1	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:62293536C>A	uc001ntl.2	-	5	8653	c.8353G>T	c.(8353-8355)GAT>TAT	p.D2785Y	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2785					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACGTCCACATCTGGACCTTCT	0.498													66	135					1.31726e-23	1.8266e-23	1	0	A	62293536	A	A	62293536	3	1	86	1	0	0	0	0	1	0	0	0	414	913	32	2	9439	2	AHNAK	11	62293536	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	3314005	62293536	72712980	136	17235											
MTL5	9633	broad.mit.edu	37	chr11	68506204	68506204	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtggtcctggaagagttGatcccgaggggaaagcagac	10	8	16	7	1	0	3	0	1	0	2	2	6	2	5	2	5	1	2	2	5	2	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:68506204G>C	uc001ooc.2	-	6	1021	c.881C>G	c.(880-882)TCA>TGA	p.S294*	MTL5_uc001ood.1_Nonsense_Mutation_p.S294*|MTL5_uc009ysi.1_3'UTR	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	294					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			TGGAAGAGTTGATCCCGAGGG	0.408													93	174					0	0	0	0	C	68506204	C	C	68506204	4	2	86	1	0	0	0	0	0	1	0	0	9989	1294	45	2	669	2	MTL5	11	68506204	Nonsense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	6212668	68506204	66500312	137	17236											
MTL5	9633	broad.mit.edu	37	chr11	68506237	68506237	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagcagacccgttgactaccGatggtaaggctccctcaagc	11	7	10	13	2	1	2	1	1	0	1	2	3	2	2	3	2	3	4	3	2	4	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:68506237G>A	uc001ooc.2	-	6	988	c.848C>T	c.(847-849)TCG>TTG	p.S283L	MTL5_uc001ood.1_Missense_Mutation_p.S283L|MTL5_uc009ysi.1_3'UTR	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	283					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			GTTGACTACCGATGGTAAGGC	0.438													78	157					0	0	0	0	A	68506237	A	A	68506237	3	1	86	1	0	0	0	0	1	0	0	0	9989	1059	37	1	702	1	MTL5	11	68506237	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	33	68506237	66500279	138	17237											
MYEOV	26579	broad.mit.edu	37	chr11	69063820	69063820	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctcctctcctcctccaccaCctcctcctcctcctcctcat	3	13	0	25	0	3	0	1	0	2	0	12	0	10	0	11	0	0	0	11	0	0	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:69063820C>A	uc001oov.2	+	3	1353	c.903C>A	c.(901-903)CAC>CAA	p.H301Q	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Missense_Mutation_p.H301Q|MYEOV_uc001oow.2_Missense_Mutation_p.H243Q	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	301											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		tcctccaccacctcctcctcc	0.269													19	8					0.00074312	0.000799495	1	0	A	69063820	A	A	69063820	3	1	86	1	0	0	0	0	1	0	0	0	10078	506	18	4	909	4	MYEOV	11	69063820	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	557583	69063820	65942696	139	17238											
TRIM49	57093	broad.mit.edu	37	chr11	89537595	89537595	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagttcatgcacagggggcAgatgagttccccctgaaaga	11	8	13	9	0	1	4	1	2	0	2	2	4	2	4	2	2	1	5	2	2	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:89537595A>G	uc001pdb.2	-	3	372	c.43T>C	c.(43-45)TGC>CGC	p.C15R		NM_020358	NP_065091	P0CI25	TRI49_HUMAN	ring finger protein 18	15	RING-type.					intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CACAGGGGGCAGATGAGTTCC	0.473													12	31					0	0	0	0	G	89537595	G	G	89537595	3	3	86	1	0	0	0	0	1	0	0	0	16591	188	7	5	1339	5	TRIM49	11	89537595	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	20473775	89537595	45468921	140	17239											
UBTFL1	642623	broad.mit.edu	37	chr11	89819398	89819398	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaacaaaagccaaaaatacaGgaacggtccagactttccaa	19	5	7	10	1	0	1	0	0	0	1	2	3	2	2	3	2	4	0	3	2	8	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:89819398G>T	uc010rub.1	+	1	281	c.281G>T	c.(280-282)AGG>ATG	p.R94M		NM_001143975	NP_001137447	P0CB47	UBFL1_HUMAN	upstream binding transcription factor, RNA	94					multicellular organismal development	cytoplasm|nucleus	DNA binding				0						CAAAAATACAGGAACGGTCCA	0.423													10	9					4.68919e-08	5.58407e-08	1	0	T	89819398	T	T	89819398	3	4	86	1	0	0	0	0	1	0	0	0	16978	1000	35	4	283	4	UBTFL1	11	89819398	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	281803	89819398	45187118	141	17240											
FAT3	120114	broad.mit.edu	37	chr11	92088310	92088310	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttctataaccttactgtgcGggccaaagacaaagggcggc	11	8	12	10	2	1	1	0	0	1	1	1	1	1	1	2	3	3	1	2	3	5	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:92088310G>T	uc001pdj.3	+	1	3049	c.3032G>T	c.(3031-3033)CGG>CTG	p.R1011L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1011	Cadherin 9.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTTACTGTGCGGGCCAAAGAC	0.453										TCGA Ovarian(4;0.039)			12	24					5.50884e-06	6.16042e-06	1	0	T	92088310	T	T	92088310	3	4	86	1	0	0	0	0	1	0	0	0	5723	1116	39	3	3034	3	FAT3	11	92088310	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	2268912	92088310	42918206	142	17241											
FAT3	120114	broad.mit.edu	37	chr11	92523307	92523307	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatgagaaaattccggattGaccctagcactggcgtgctc	10	9	11	11	2	0	2	0	2	0	1	2	4	1	3	2	2	2	3	2	2	3	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:92523307G>T	uc001pdj.3	+	7	4551	c.4534G>T	c.(4534-4536)GAC>TAC	p.D1512Y		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1512	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTCCGGATTGACCCTAGCAC	0.488										TCGA Ovarian(4;0.039)			20	107					2.37509e-13	3.037e-13	1	0	T	92523307	T	T	92523307	3	4	86	1	0	0	0	0	1	0	0	0	5723	1290	45	2	4560	2	FAT3	11	92523307	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	434997	92523307	42483209	143	17242											
FAT3	120114	broad.mit.edu	37	chr11	92573756	92573756	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagtgggcaccagcatctTgcagctggtggtgacagaca	9	7	14	11	0	1	2	0	1	1	1	1	2	1	2	2	3	3	4	2	3	0	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:92573756T>C	uc001pdj.3	+	17	10414	c.10397T>C	c.(10396-10398)TTG>TCG	p.L3466S	FAT3_uc001pdi.3_5'UTR	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3466	Cadherin 32.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACCAGCATCTTGCAGCTGGTG	0.388										TCGA Ovarian(4;0.039)			12	28					0	0	0	0	C	92573756	C	C	92573756	3	2	86	1	0	0	0	0	1	0	0	0	5723	1821	63	5	10463	5	FAT3	11	92573756	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	50449	92573756	42432760	144	17243											
OR6M1	390261	broad.mit.edu	37	chr11	123676665	123676665	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgctgttcatgatgacCgtgtagtgcagtgggtcgca	6	11	14	10	2	1	2	1	2	0	0	2	2	1	2	2	1	2	5	2	1	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr11:123676665C>A	uc010rzz.1	-	1	393	c.393G>T	c.(391-393)ACG>ACT	p.T131T		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		TCATGATGACCGTGTAGTGCA	0.517													19	20					1.64113e-05	1.80931e-05	1	0	A	123676665	A	A	123676665	2	1	86	1	0	0	0	0	0	0	0	1	11259	639	23	3		3	OR6M1	11	123676665	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	31102909	123676665	11329851	145	17244											
CD163L1	283316	broad.mit.edu	37	chr12	7556294	7556294	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcacgacgactgccaaagacGctgaacggacatcctagctg	12	5	11	13	4	0	2	0	1	0	1	1	5	1	3	2	1	3	3	2	1	3	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:7556294G>A	uc001qsy.2	-	6	1271	c.1245C>T	c.(1243-1245)AGC>AGT	p.S415S	CD163L1_uc010sge.1_Silent_p.S425S	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	415	SRCR 4.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TGCCAAAGACGCTGAACGGAC	0.458													42	128					0	0	0	0	A	7556294	A	A	7556294	2	1	86	1	0	0	0	0	0	0	0	1	2983	1078	38	1		1	CD163L1	12	7556294	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08		7556294	126295601	146	17245											
PZP	5858	broad.mit.edu	37	chr12	9317736	9317736	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccctcattttccttaccCggatgcatttgggaaggtag	8	13	9	11	1	2	0	2	0	0	0	3	2	3	2	3	3	2	2	3	3	3	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:9317736C>A	uc001qvl.2	-	19	2515	c.2486G>T	c.(2485-2487)CGG>CTG	p.R829L	PZP_uc009zgl.2_Missense_Mutation_p.R698L|PZP_uc010sgo.1_RNA|PZP_uc009zgm.1_Missense_Mutation_p.R161L	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TTTCCTTACCCGGATGCATTT	0.463													17	71					5.35267e-07	6.1853e-07	1	0	A	9317736	A	A	9317736	3	1	86	1	0	0	0	0	1	0	0	0	12934	666	23	3	2034	3	PZP	12	9317736	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	1761442	9317736	124534159	147	17246											
PRB3	5544	broad.mit.edu	37	chr12	11420652	11420652	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggctttcccggatgaggCgggggaccttgggactggtt	4	11	17	9	2	1	1	0	1	1	0	2	4	2	4	2	7	0	2	2	7	0	3	rs74786167		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:11420652C>T	uc001qzs.2	-	3	569	c.531G>A	c.(529-531)CCG>CCA	p.P177P	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	177	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.|6.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			CCGGATGAGGCGGGGGACCTT	0.642													7	186					0	0	0	0	T	11420652	T	T	11420652	2	4	86	1	0	0	0	0	0	0	0	1	12506	755	27	1		1	PRB3	12	11420652	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	2102916	11420652	122431243	148	17247											
PTPRO	5800	broad.mit.edu	37	chr12	15637161	15637161	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtgaccaagccatccaGatcaatcactgtgttaacaa	13	10	8	10	0	2	2	2	1	0	1	3	2	3	2	3	1	2	1	3	1	4	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:15637161G>T	uc001rcv.1	+	2	503	c.329G>T	c.(328-330)AGA>ATA	p.R110I	PTPRO_uc001rcw.1_Missense_Mutation_p.R110I|PTPRO_uc001rcu.1_Missense_Mutation_p.R110I	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	110	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				AAGCCATCCAGATCAATCACT	0.413													10	38					7.48243e-07	8.61446e-07	1	0	T	15637161	T	T	15637161	3	4	86	1	0	0	0	0	1	0	0	0	12874	942	33	2	335	2	PTPRO	12	15637161	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	4216509	15637161	118214734	149	17248											
SLCO1B3	28234	broad.mit.edu	37	chr12	21030851	21030851	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtacggtcagtctgcatcTcatgctaactttttgttggg	7	15	10	9	1	3	0	2	0	2	0	4	0	3	0	0	2	4	4	0	2	2	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:21030851T>A	uc001rek.2	+	9	1242	c.1116T>A	c.(1114-1116)TCT>TCA	p.S372S	SLCO1B3_uc001rel.2_Silent_p.S372S|SLCO1B3_uc010sil.1_Silent_p.S372S|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Silent_p.S197S	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	372	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					AGTCTGCATCTCATGCTAACT	0.328													17	53					0	0	0	0	A	21030851	A	A	21030851	2	1	86	1	0	0	0	0	0	0	0	1	14788	1538	54	5		5	SLCO1B3	12	21030851	Silent	SNP	T	TCGA-CN-6995-01A-31D-2012-08	5393690	21030851	112821044	150	17249											
IFLTD1	160492	broad.mit.edu	37	chr12	25672821	25672821	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacttgagcttgttccacCtgataatttgagatatcttt	11	16	7	7	0	1	4	0	3	1	2	2	5	2	4	2	0	2	2	2	0	3	7			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:25672821C>A	uc001rgs.2	-	6	1074	c.924G>T	c.(922-924)CAG>CAT	p.Q308H	IFLTD1_uc001rgt.1_Missense_Mutation_p.Q211H|IFLTD1_uc010sji.1_Missense_Mutation_p.Q329H|IFLTD1_uc010sjj.1_Missense_Mutation_p.Q245H|IFLTD1_uc009zjc.2_Missense_Mutation_p.Q289H	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	308						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					CTTGTTCCACCTGATAATTTG	0.388													6	32					1.06961e-07	1.26409e-07	1	0	A	25672821	A	A	25672821	3	1	86	1	0	0	0	0	1	0	0	0	7569	680	24	4	254	4	IFLTD1	12	25672821	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	4641970	25672821	108179074	151	17250											
OVCH1	341350	broad.mit.edu	37	chr12	29597152	29597152	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcagaagaacatcctcacaAgggaccaagtgctctctgtt	12	9	9	11	0	3	2	2	0	1	2	5	3	4	3	2	1	2	2	2	1	4	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:29597152A>G	uc001rix.1	-	24	2943	c.2943T>C	c.(2941-2943)CCT>CCC	p.P981P		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	981					proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CATCCTCACAAGGGACCAAGT	0.403													3	178					0	0	0	0	G	29597152	G	G	29597152	2	3	86	1	0	0	0	0	0	0	0	1	11377	59	3	5		5	OVCH1	12	29597152	Silent	SNP	A	TCGA-CN-6995-01A-31D-2012-08	3924331	29597152	104254743	152	17251											
CNTN1	1272	broad.mit.edu	37	chr12	41312540	41312540	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggaaaagtctcactcaactGtagggcacgagccagccctt	12	7	10	12	1	2	0	2	0	1	0	3	2	2	1	2	2	3	2	2	2	4	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:41312540G>T	uc001rmm.1	+	4	307	c.194G>T	c.(193-195)TGT>TTT	p.C65F	CNTN1_uc009zjy.1_Missense_Mutation_p.C65F|CNTN1_uc001rmn.1_Missense_Mutation_p.C54F|CNTN1_uc001rmo.2_Missense_Mutation_p.C65F	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	65	Ig-like C2-type 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TCACTCAACTGTAGGGCACGA	0.438													8	60					3.09899e-07	3.60777e-07	1	0	T	41312540	T	T	41312540	3	4	86	1	0	0	0	0	1	0	0	0	3655	1377	48	4	204	4	CNTN1	12	41312540	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	11715388	41312540	92539355	153	17252											
IRAK4	51135	broad.mit.edu	37	chr12	44180289	44180289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgatgctgattccacttcaGttgaagctatgtactctgtt	9	16	8	8	0	2	3	1	3	1	0	3	3	3	3	1	0	3	5	1	0	3	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:44180289G>A	uc001rnu.3	+	12	1406	c.1276G>A	c.(1276-1278)GTT>ATT	p.V426I	IRAK4_uc001rnt.3_Missense_Mutation_p.V426I|IRAK4_uc001rnx.3_Missense_Mutation_p.V302I|IRAK4_uc001rny.3_Missense_Mutation_p.V302I|IRAK4_uc010sky.1_Missense_Mutation_p.V302I|IRAK4_uc001rnv.3_Missense_Mutation_p.V302I|IRAK4_uc001rnw.3_Missense_Mutation_p.V302I	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	426	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		TTCCACTTCAGTTGAAGCTAT	0.284													16	87					0	0	0	0	A	44180289	A	A	44180289	3	1	86	1	0	0	0	0	1	0	0	0	7864	1029	36	4	1314	4	IRAK4	12	44180289	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	2867749	44180289	89671606	154	17253											
SCN8A	6334	broad.mit.edu	37	chr12	52056869	52056869	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttgacccatactatttgAcgcagaaagtgagttggagg	12	11	11	7	1	0	4	0	3	0	1	0	5	0	5	1	2	1	2	1	2	3	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:52056869A>T	uc001ryw.2	+	2	446	c.268A>T	c.(268-270)ACG>TCG	p.T90S		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	90					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ATACTATTTGACGCAGAAAGT	0.527													51	92					0	0	0	0	T	52056869	T	T	52056869	3	4	86	1	0	0	0	0	1	0	0	0	13989	275	10	5	270	5	SCN8A	12	52056869	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	7876580	52056869	81795026	155	17254											
MBD6	114785	broad.mit.edu	37	chr12	57918502	57918502	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgaccctgtcctctcgcaGtccaagtggcacagagctgt	7	10	10	14	1	2	2	0	1	2	1	5	2	4	2	3	1	1	3	3	1	1	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:57918502G>A	uc001soj.1	+	4	338	c.114_splice	c.e4-1	p.S38_splice	MBD6_uc001sok.1_5'Flank|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6							chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						TCCTCTCGCAGTCCAAGTGGC	0.542													39	47					0	0	0	0	A	57918502	A	A	57918502	5	1	86	1	0	0	0	0	0	0	1	0	9401	1043	36	4	119	4	MBD6	12	57918502	Splice_Site	SNP	G	TCGA-CN-6995-01A-31D-2012-08	5861633	57918502	75933393	156	17255											
TRHDE	29953	broad.mit.edu	37	chr12	72956711	72956711	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccagatgggttatcctgttAtcaccatcttgggaaacaca	11	12	8	10	0	2	1	1	0	1	1	4	2	4	2	3	2	1	2	3	2	3	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:72956711A>G	uc001sxa.2	+	9	1828	c.1798A>G	c.(1798-1800)ATC>GTC	p.I600V		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	600	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTATCCTGTTATCACCATCTT	0.328													9	70					0	0	0	0	G	72956711	G	G	72956711	3	3	86	1	0	0	0	0	1	0	0	0	16546	449	16	5	1832	5	TRHDE	12	72956711	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	15038209	72956711	60895184	157	17256											
KCNC2	3747	broad.mit.edu	37	chr12	75601187	75601187	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cccgagccccgccgcgtcctCgatgcccagcctcttggccg	3	6	11	21	6	1	0	0	0	1	0	3	2	2	0	8	1	3	0	8	1	0	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:75601187C>G	uc001sxg.1	-	2	1121	c.577G>C	c.(577-579)GAG>CAG	p.E193Q	KCNC2_uc009zry.2_Missense_Mutation_p.E193Q|KCNC2_uc001sxe.2_Missense_Mutation_p.E193Q|KCNC2_uc001sxf.2_Missense_Mutation_p.E193Q|KCNC2_uc010stw.1_Missense_Mutation_p.E193Q	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	193	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.E193D(1)		breast(2)|pancreas(2)|skin(1)|lung(1)	6						GCCGCGTCCTCGATGCCCAGC	0.721													4	22					0	0	0	0	G	75601187	G	G	75601187	3	3	86	1	0	0	0	0	1	0	0	0	8054	893	31	3	1421	3	KCNC2	12	75601187	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	2644476	75601187	58250708	158	17257											
GLIPR1	11010	broad.mit.edu	37	chr12	75892486	75892486	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttacagttaaccgacagcGagaccaagtcaaacgtacgt	14	8	8	11	4	1	1	1	0	0	1	1	3	1	1	2	0	5	2	2	0	5	4	rs3736392	by1000genomes	TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:75892486G>A	uc001sxs.2	+	5	780	c.632G>A	c.(631-633)CGA>CAA	p.R211Q	GLIPR1_uc009zsb.1_Missense_Mutation_p.E235K|KRR1_uc001sxt.2_3'UTR|KRR1_uc009zsc.2_3'UTR	NM_006851	NP_006842	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1 precursor	211					cellular lipid metabolic process	extracellular region|integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3						AACCGACAGCGAGACCAAGTC	0.323													11	34					0	0	0	0	A	75892486	A	A	75892486	3	1	86	1	0	0	0	0	1	0	0	0	6478	1058	37	1	650	1	GLIPR1	12	75892486	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	291299	75892486	57959409	159	17258											
PPP1R12A	4659	broad.mit.edu	37	chr12	80226236	80226236	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcatctctaagcatgatccGttcttcttcctttcgagctg	6	15	8	12	2	3	1	0	1	3	0	7	2	5	1	2	1	2	4	2	1	1	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:80226236G>A	uc001syz.2	-	4	790	c.523C>T	c.(523-525)CGG>TGG	p.R175W	PPP1R12A_uc010suc.1_Missense_Mutation_p.R88W|PPP1R12A_uc001sza.2_Missense_Mutation_p.R175W|PPP1R12A_uc010sud.1_Missense_Mutation_p.R175W|PPP1R12A_uc001szb.2_Missense_Mutation_p.R175W|PPP1R12A_uc001szc.2_Missense_Mutation_p.R175W	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	175						contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						AGCATGATCCGTTCTTCTTCC	0.388													21	114					0	0	0	0	A	80226236	A	A	80226236	3	1	86	1	0	0	0	0	1	0	0	0	12414	1144	40	1	2657	1	PPP1R12A	12	80226236	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	4333750	80226236	53625659	160	17259											
ACSS3	79611	broad.mit.edu	37	chr12	81472018	81472018	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcagggctttagtggtccCgggcccgcggggcggtctcg	2	8	17	14	5	2	0	1	0	1	0	4	0	3	0	3	6	0	1	3	6	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:81472018C>T	uc001szl.1	+	1	210	c.119C>T	c.(118-120)CCG>CTG	p.P40L	ACSS3_uc001szm.1_Missense_Mutation_p.P40L	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	40						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TTAGTGGTCCCGGGCCCGCGG	0.731													3	19					0	0	0	0	T	81472018	T	T	81472018	3	4	86	1	0	0	0	0	1	0	0	0	190	652	23	1	121	1	ACSS3	12	81472018	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	1245782	81472018	52379877	161	17260											
TMTC2	160335	broad.mit.edu	37	chr12	83250841	83250841	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaactccatggacgcacAttttctacaatgatttttgg	12	13	7	9	1	1	2	0	1	1	1	2	3	2	3	1	2	2	1	1	2	3	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:83250841A>G	uc001szt.2	+	2	568	c.136A>G	c.(136-138)ATT>GTT	p.I46V	TMTC2_uc001szr.1_Missense_Mutation_p.I46V|TMTC2_uc001szs.1_Missense_Mutation_p.I46V|TMTC2_uc010suk.1_Intron	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	46						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						ATGGACGCACATTTTCTACAA	0.428													61	117					0	0	0	0	G	83250841	G	G	83250841	3	3	86	1	0	0	0	0	1	0	0	0	16327	217	8	5	142	5	TMTC2	12	83250841	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	1778823	83250841	50601054	162	17261											
APAF1	317	broad.mit.edu	37	chr12	99056319	99056319	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattcttcttacaaccagaGacaagagtgttacagattca	15	11	7	8	0	3	4	1	0	2	4	3	5	3	4	1	0	3	1	1	0	4	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:99056319G>T	uc001tfz.2	+	6	1373	c.796G>T	c.(796-798)GAC>TAC	p.D266Y	APAF1_uc001tfy.2_Missense_Mutation_p.D255Y|APAF1_uc001tga.2_Missense_Mutation_p.D255Y|APAF1_uc001tgb.2_Missense_Mutation_p.D266Y|APAF1_uc001tgc.2_Missense_Mutation_p.D266Y	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	266	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	TACAACCAGAGACAAGAGTGT	0.308													17	25					2.48551e-13	3.16521e-13	1	0	T	99056319	T	T	99056319	3	4	86	1	0	0	0	0	1	0	0	0	755	942	33	2	814	2	APAF1	12	99056319	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	15805478	99056319	34795576	163	17262											
ANO4	121601	broad.mit.edu	37	chr12	101381432	101381432	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctacactgcccctttcagcCagcaaaggatccatcagtga	11	8	8	14	0	2	1	2	1	0	0	3	2	3	2	4	1	4	2	4	1	2	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:101381432C>A	uc010svm.1	+	8	1290	c.718C>A	c.(718-720)CAG>AAG	p.Q240K	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.Q205K|ANO4_uc001thx.2_Missense_Mutation_p.Q240K	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	240	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						CCCTTTCAGCCAGCAAAGGAT	0.527										HNSCC(74;0.22)	OREG0022059	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	142					8.16721e-17	1.08433e-16	1	0	A	101381432	A	A	101381432	3	1	86	1	0	0	0	0	1	0	0	0	699	595	21	4	635	4	ANO4	12	101381432	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	2325113	101381432	32470463	164	17263											
CCDC92	80212	broad.mit.edu	37	chr12	124421993	124421993	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctctttttcatgcggcggCgaggcgtttcgggtagcttg	3	13	16	9	5	2	0	1	0	1	0	3	1	2	0	0	5	2	4	0	5	1	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr12:124421993C>T	uc001ufw.1	-	5	755	c.608G>A	c.(607-609)CGC>CAC	p.R203H	CCDC92_uc001ufv.1_Missense_Mutation_p.R186H|CCDC92_uc001ufx.1_Missense_Mutation_p.R203H|CCDC92_uc001ufy.1_Missense_Mutation_p.R186H	NM_025140	NP_079416	Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	203											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		CATGCGGCGGCGAGGCGTTTC	0.612													33	51					0	0	0	0	T	124421993	T	T	124421993	3	4	86	1	0	0	0	0	1	0	0	0	2884	768	27	1	391	1	CCDC92	12	124421993	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	23040561	124421993	9429902	165	17264											
N6AMT2	221143	broad.mit.edu	37	chr13	21311925	21311925	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcagagcagtttcctgactaTaccaaaactggctcagttgc	11	10	9	11	0	1	2	1	1	0	1	2	2	2	2	2	1	4	5	2	1	4	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:21311925T>C	uc001uno.1	-	3	245	c.164A>G	c.(163-165)TAT>TGT	p.Y55C	N6AMT2_uc009zzr.1_Missense_Mutation_p.Y55C|N6AMT2_uc001unp.2_Intron	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	55							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		TTCCTGACTATACCAAAACTG	0.393													13	16					0	0	0	0	C	21311925	C	C	21311925	3	2	86	1	0	0	0	0	1	0	0	0	10168	1406	49	5	492	5	N6AMT2	13	21311925	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08		21311925	93857953	166	17265											
FLT1	2321	broad.mit.edu	37	chr13	28931821	28931821	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctggtcctaaaataatTcctgaggggtgagagatgtt	10	13	11	7	0	0	3	0	2	0	1	3	4	3	3	3	3	0	1	3	3	3	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:28931821T>A	uc001usb.3	-	15	2403	c.2118A>T	c.(2116-2118)GGA>GGT	p.G706G		NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	706	Ig-like C2-type 7.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTAAAATAATTCCTGAGGGGT	0.443													64	50					0	0	0	0	A	28931821	A	A	28931821	2	1	86	1	0	0	0	0	0	0	0	1	5973	1797	62	5		5	FLT1	13	28931821	Silent	SNP	T	TCGA-CN-6995-01A-31D-2012-08	7619896	28931821	86238057	167	17266											
SIAH3	283514	broad.mit.edu	37	chr13	46357673	46357673	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacgcactcaagaacagaccGgggcgtggcctcccacttga	10	5	11	15	3	1	3	1	1	0	2	2	3	2	3	3	3	1	1	3	3	2	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:46357673G>A	uc001vap.2	-	2	737	c.655C>T	c.(655-657)CGG>TGG	p.R219W		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	219					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						AGAACAGACCGGGGCGTGGCC	0.617													22	26					0	0	0	0	A	46357673	A	A	46357673	3	1	86	1	0	0	0	0	1	0	0	0	14366	1115	39	1	158	1	SIAH3	13	46357673	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	17425852	46357673	68812205	168	17267											
SLITRK5	26050	broad.mit.edu	37	chr13	88329467	88329467	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacatgcgctccattaagtcGgagctgctgtgccctgacta	8	10	11	12	2	0	1	0	1	0	0	2	3	1	2	2	1	4	3	2	1	2	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:88329467G>A	uc001vln.2	+	2	2043	c.1824G>A	c.(1822-1824)TCG>TCA	p.S608S	SLITRK5_uc010tic.1_Silent_p.S367S	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	608	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCATTAAGTCGGAGCTGCTGT	0.582													23	154					0	0	0	0	A	88329467	A	A	88329467	2	1	86	1	0	0	0	0	0	0	0	1	14810	1103	39	1		1	SLITRK5	13	88329467	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	41971794	88329467	26840411	169	17268											
NALCN	259232	broad.mit.edu	37	chr13	101997697	101997697	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccatgcatttaaatccaggtGggcactggtagccttcttct	8	13	9	11	0	2	0	0	0	2	0	3	0	3	0	3	3	2	3	3	3	3	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:101997697G>T	uc001vox.1	-	7	908	c.719C>A	c.(718-720)CCA>CAA	p.P240Q	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.P240Q|NALCN_uc001vpa.2_Missense_Mutation_p.P240Q	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	240	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AAATCCAGGTGGGCACTGGTA	0.448													51	42					5.13769e-22	7.03052e-22	1	0	T	101997697	T	T	101997697	3	4	86	1	0	0	0	0	1	0	0	0	10201	1348	47	4	4649	4	NALCN	13	101997697	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	13668230	101997697	13172181	170	17269											
IRS2	8660	broad.mit.edu	37	chr13	110436062	110436062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcggagaagaagtcgggcGgggtgcccgtggtgaccgcg	6	5	20	10	6	0	3	0	1	0	2	1	4	0	3	2	5	2	0	2	5	2	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr13:110436062G>A	uc001vqv.2	-	1	2853	c.2339C>T	c.(2338-2340)CCG>CTG	p.P780L		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	780					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			GAAGTCGGGCGGGGTGCCCGT	0.692													7	3					0	0	0	0	A	110436062	A	A	110436062	3	1	86	1	0	0	0	0	1	0	0	0	7880	1116	39	1	1685	1	IRS2	13	110436062	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	8438365	110436062	4733816	171	17270											
METT11D1	64745	broad.mit.edu	37	chr14	21464756	21464757	+	Missense_Mutation	DNP	GC	AT	AT																															gtctccagaggaggctcatcGctggccccgtatcactcagc																										TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:21464756_21464757GC>AT	uc001vyn.2	+	13	1348_1349	c.1151_1152GC>AT	c.(1150-1152)CGC>CAT	p.R384H	METT11D1_uc001vym.2_Missense_Mutation_p.R384H|METT11D1_uc001vyo.2_Missense_Mutation_p.R384H|METT11D1_uc001vyp.2_Missense_Mutation_p.R226H|METT11D1_uc001vyq.2_Missense_Mutation_p.R226H|SLC39A2_uc001vyr.2_5'Flank|SLC39A2_uc001vys.2_5'Flank	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	384					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GAGGCTCATCGCTGGCCCCGTA	0.515													16	28					0	0	0	0	AT	21464757	AT	AT	21464756	3	1	86	1	0	0	0	0	1	0	0	0	9544	1087	38	1	1201	1	METT11D1	14	21464756	Missense_Mutation	DNP	GC	TCGA-CN-6995-01A-31D-2012-08		21464756	85884784	172	17271											
JPH4	84502	broad.mit.edu	37	chr14	24045142	24045142	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgccctcgtagcgcagcccGttggagcgctggctgacgcc	4	7	14	16	6	0	1	0	1	0	0	2	2	0	2	3	2	3	5	3	2	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:24045142G>A	uc001wkq.2	-	4	1821	c.903C>T	c.(901-903)AAC>AAT	p.N301N	JPH4_uc010tnr.1_5'Flank|JPH4_uc001wkr.2_Silent_p.N301N|JPH4_uc001wks.2_Silent_p.N301N	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	301	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		AGCGCAGCCCGTTGGAGCGCT	0.677													5	25					0	0	0	0	A	24045142	A	A	24045142	2	1	86	1	0	0	0	0	0	0	0	1	8002	1136	40	1		1	JPH4	14	24045142	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	2580386	24045142	83304398	173	17272											
C14orf21	161424	broad.mit.edu	37	chr14	24769788	24769788	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgtggcctgtcaccgatGcggggtccatgtattacaaa	9	10	11	11	2	1	0	1	0	0	0	2	1	2	0	3	3	2	1	3	3	3	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:24769788G>C	uc001wol.1	+	2	485	c.422G>C	c.(421-423)TGC>TCC	p.C141S	C14orf21_uc001wom.1_5'Flank|DHRS1_uc001woj.1_5'Flank|DHRS1_uc001wok.2_5'Flank	NM_174913	NP_777573	Q86U38	CN021_HUMAN	hypothetical protein LOC161424	141							RNA binding			breast(2)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(265;0.0185)		TGTCACCGATGCGGGGTCCAT	0.483													48	128					0	0	0	0	C	24769788	C	C	24769788	3	2	86	1	0	0	0	0	1	0	0	0	1775	1319	46	4	428	4	C14orf21	14	24769788	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	724646	24769788	82579752	174	17273											
NPAS3	64067	broad.mit.edu	37	chr14	33684540	33684540	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atccatcattcgacttacaaTtagctatctgaaaatgaggg	14	12	7	8	1	2	2	1	2	1	0	4	3	3	2	1	1	2	1	1	1	6	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:33684540T>A	uc001wru.2	+	3	357	c.293T>A	c.(292-294)ATT>AAT	p.I98N	NPAS3_uc001wrs.2_Missense_Mutation_p.I68N|NPAS3_uc001wrt.2_Missense_Mutation_p.I68N|NPAS3_uc001wrv.2_Missense_Mutation_p.I68N|NPAS3_uc001wrw.2_5'UTR	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	98	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CGACTTACAATTAGCTATCTG	0.463													34	66					0	0	0	0	A	33684540	A	A	33684540	3	1	86	1	0	0	0	0	1	0	0	0	10618	1493	52	5	303	5	NPAS3	14	33684540	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	8914752	33684540	73665000	175	17274											
LRFN5	145581	broad.mit.edu	37	chr14	42360587	42360587	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagtcgtgggttgcatccAgtttactacggaacaggatt	11	11	12	7	2	0	1	0	0	0	1	2	3	1	3	1	3	4	3	1	3	4	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:42360587A>G	uc001wvm.2	+	4	2718	c.1520A>G	c.(1519-1521)CAG>CGG	p.Q507R	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	507	Extracellular (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GGTTGCATCCAGTTTACTACG	0.433										HNSCC(30;0.082)			25	95					0	0	0	0	G	42360587	G	G	42360587	3	3	86	1	0	0	0	0	1	0	0	0	8991	188	7	5	1526	5	LRFN5	14	42360587	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	8676047	42360587	64988953	176	17275											
GPR137C	283554	broad.mit.edu	37	chr14	53020234	53020234	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctcacctgcacttcttcccCcactggctgctctactgctt	4	13	6	18	0	3	0	1	0	2	0	4	0	4	0	3	1	4	5	3	1	1	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:53020234C>A	uc001wzu.3	+	1	369	c.369C>A	c.(367-369)CCC>CCA	p.P123P	TXNDC16_uc010tqu.1_5'Flank|TXNDC16_uc001wzs.2_5'Flank|TXNDC16_uc010aoe.2_5'Flank|GPR137C_uc001wzt.3_Silent_p.P123P	NM_001099652	NP_001093122	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	123	Helical; (Potential).					integral to membrane					0	Breast(41;0.0716)					ACTTCTTCCCCCACTGGCTGC	0.652													12	56					7.03913e-09	8.51243e-09	1	0	A	53020234	A	A	53020234	2	1	86	1	0	0	0	0	0	0	0	1	6685	610	22	4		4	GPR137C	14	53020234	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	10659647	53020234	54329306	177	17276											
PSMC6	5706	broad.mit.edu	37	chr14	53173987	53173987	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggactaccgcaagaagttgcTtgaacacaaggagatcgacg	14	6	12	9	3	0	3	0	1	0	2	1	6	0	4	1	2	3	3	1	2	5	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:53173987T>C	uc010tqx.1	+	1	92	c.92T>C	c.(91-93)CTT>CCT	p.L31P	PSMC6_uc010tqv.1_Missense_Mutation_p.L31P|PSMC6_uc010tqw.1_Silent_p.L24L	NM_002806	NP_002797	P62333	PRS10_HUMAN	proteasome 26S ATPase subunit 6	17					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			lung(1)	1	Breast(41;0.176)					AAGAAGTTGCTTGAACACAAG	0.537													7	30					0	0	0	0	C	53173987	C	C	53173987	3	2	86	1	0	0	0	0	1	0	0	0	12753	1609	56	5	94	5	PSMC6	14	53173987	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	153753	53173987	54175553	178	17277											
RIN3	79890	broad.mit.edu	37	chr14	93118018	93118018	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggattccccctagtctcCagcctcaggcccacagccca	7	6	7	21	1	2	0	1	0	1	0	4	1	3	1	7	2	2	0	7	2	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr14:93118018C>G	uc001yap.2	+	6	776	c.624C>G	c.(622-624)TCC>TCG	p.S208S	RIN3_uc010auk.2_5'UTR|RIN3_uc001yaq.2_Silent_p.S133S|RIN3_uc001yar.1_5'UTR|RIN3_uc001yas.1_5'UTR	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	208					endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CCCTAGTCTCCAGCCTCAGGC	0.572													17	65					0	0	0	0	G	93118018	G	G	93118018	2	3	86	1	0	0	0	0	0	0	0	1	13438	581	21	4		4	RIN3	14	93118018	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	39944031	93118018	14231522	179	17278											
C15orf2	23742	broad.mit.edu	37	chr15	24923749	24923749	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggcagcagaagtctgacaGttcttttattctggggaatc	9	13	12	7	0	3	2	0	1	3	1	4	3	3	3	0	3	1	3	0	3	3	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:24923749G>T	uc001ywo.2	+	1	3209	c.2735G>T	c.(2734-2736)AGT>ATT	p.S912I		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	912					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AAGTCTGACAGTTCTTTTATT	0.488													42	114					1.07121e-22	1.47232e-22	1	0	T	24923749	T	T	24923749	3	4	86	1	0	0	0	0	1	0	0	0	1790	1029	36	4	2737	4	C15orf2	15	24923749	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08		24923749	77607643	180	17279											
ATP10A	57194	broad.mit.edu	37	chr15	25940059	25940059	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgacagcagaggacggagcGgcactgcttggcaaggaaga	12	3	16	10	3	0	2	0	0	0	2	0	6	0	5	1	5	3	4	1	5	2	1	rs147432497		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:25940059G>A	uc010ayu.2	-	14	3101	c.2995C>T	c.(2995-2997)CGC>TGC	p.R999C		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	999	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		AGGACGGAGCGGCACTGCTTG	0.597													12	42					0	0	0	0	A	25940059	A	A	25940059	3	1	86	1	0	0	0	0	1	0	0	0	1118	1116	39	1	1536	1	ATP10A	15	25940059	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1016310	25940059	76591333	181	17280											
ARHGAP11A	9824	broad.mit.edu	37	chr15	32921915	32921915	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaagcacaattttaactttGagctgttgccaagtaatctc	12	14	6	9	0	2	1	1	1	1	0	3	1	2	1	1	0	4	4	1	0	5	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:32921915G>T	uc001zgy.1	+	8	1779	c.1057G>T	c.(1057-1059)GAG>TAG	p.E353*	ARHGAP11A_uc010ubw.1_Nonsense_Mutation_p.E164*|ARHGAP11A_uc001zgw.2_Nonsense_Mutation_p.E353*|ARHGAP11A_uc001zgx.2_Nonsense_Mutation_p.E353*|ARHGAP11A_uc010ubx.1_Nonsense_Mutation_p.E164*	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	353					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TTTTAACTTTGAGCTGTTGCC	0.353													11	33					1.08611e-07	1.27874e-07	1	0	T	32921915	T	T	32921915	4	4	86	1	0	0	0	0	0	1	0	0	863	1291	45	2	1087	2	ARHGAP11A	15	32921915	Nonsense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	6981856	32921915	69609477	182	17281											
THBS1	7057	broad.mit.edu	37	chr15	39886511	39886511	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttccctgcagagtggtgatGtatgaagggaagaaaatcat	13	11	12	5	0	1	4	1	2	0	2	2	5	2	5	1	2	1	2	1	2	5	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:39886511G>T	uc001zkh.2	+	21	3554	c.3375G>T	c.(3373-3375)ATG>ATT	p.M1125I	THBS1_uc010bbi.2_Missense_Mutation_p.M597I	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	1125	TSP C-terminal.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GAGTGGTGATGTATGAAGGGA	0.388													23	40					1.87028e-06	2.1066e-06	1	0	T	39886511	T	T	39886511	3	4	86	1	0	0	0	0	1	0	0	0	15919	1377	48	4	3453	4	THBS1	15	39886511	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	6964596	39886511	62644881	183	17282											
DLL4	54567	broad.mit.edu	37	chr15	41228746	41228746	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccgctgcgagttccccGtgggcttgccgcccagcttc	3	8	13	17	4	0	0	0	0	0	0	2	1	1	0	5	1	4	5	5	1	0	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:41228746G>A	uc001zng.1	+	9	1881	c.1561G>A	c.(1561-1563)GTG>ATG	p.V521M		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	521	Extracellular (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CGAGTTCCCCGTGGGCTTGCC	0.652													7	13					0	0	0	0	A	41228746	A	A	41228746	3	1	86	1	0	0	0	0	1	0	0	0	4590	1145	40	1	1595	1	DLL4	15	41228746	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1342235	41228746	61302646	184	17283											
LTK	4058	broad.mit.edu	37	chr15	41804997	41804997	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accacgctggtccccgcgtaCgccccgtcacattgtgtctg	5	9	10	17	5	2	0	1	0	1	0	3	0	3	0	5	1	1	2	5	1	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:41804997C>T	uc001zoa.3	-	3	445	c.267G>A	c.(265-267)GCG>GCA	p.A89A	LTK_uc001zob.3_Silent_p.A89A|LTK_uc010ucx.1_Silent_p.A89A|LTK_uc010bcg.2_Intron	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	89	Extracellular (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		TCCCCGCGTACGCCCCGTCAC	0.692										TSP Lung(18;0.14)			5	26					0	0	0	0	T	41804997	T	T	41804997	2	4	86	1	0	0	0	0	0	0	0	1	9130	523	19	1		1	LTK	15	41804997	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	576251	41804997	60726395	185	17284											
ADAL	161823	broad.mit.edu	37	chr15	43638089	43638089	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acagaagaggtggccctttaGtagccaaggagactgtaaaa	15	7	12	7	0	0	3	0	0	0	3	0	4	0	3	2	3	1	2	2	3	6	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:43638089G>A	uc010udo.1	+	9	1037	c.463G>A	c.(463-465)GTA>ATA	p.V155I	ADAL_uc001zrh.2_Missense_Mutation_p.V155I|ADAL_uc001zri.1_Missense_Mutation_p.V40I	NM_001159280	NP_001152752	Q6DHV7	ADAL_HUMAN	adenosine deaminase-like isoform 1	155					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding				0		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		TGGCCCTTTAGTAGCCAAGGA	0.408													28	49					0	0	0	0	A	43638089	A	A	43638089	3	1	86	1	0	0	0	0	1	0	0	0	233	1029	36	4	485	4	ADAL	15	43638089	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1833092	43638089	58893303	186	17285											
SPG11	80208	broad.mit.edu	37	chr15	44890998	44890998	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggtatgtggaaggaggagagCcctataacataggcttcatt	12	10	13	6	0	1	1	1	0	0	1	1	4	1	3	1	5	2	2	1	5	5	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:44890998C>A	uc001ztx.2	-	22	3754	c.3723G>T	c.(3721-3723)GGG>GGT	p.G1241G	SPG11_uc010ueh.1_Silent_p.G1241G|SPG11_uc010uei.1_Silent_p.G1241G|SPG11_uc001zty.1_5'UTR	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1241	Helical; (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AGGAGGAGAGCCCTATAACAT	0.418													18	37					3.41278e-10	4.24218e-10	1	0	A	44890998	A	A	44890998	2	1	86	1	0	0	0	0	0	0	0	1	15107	726	26	4		4	SPG11	15	44890998	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	1252909	44890998	57640394	187	17286											
HERC1	8925	broad.mit.edu	37	chr15	63986610	63986610	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggcaacaactgcaggggcTgtcctagcatggtgtctgta	8	11	13	9	0	1	0	0	0	1	0	2	0	2	0	1	4	4	5	1	4	4	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:63986610T>A	uc002amp.2	-	29	5529	c.5381A>T	c.(5380-5382)CAG>CTG	p.Q1794L		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1794					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CTGCAGGGGCTGTCCTAGCAT	0.473													18	40					0	0	0	0	A	63986610	A	A	63986610	3	1	86	1	0	0	0	0	1	0	0	0	7096	1580	55	5	9404	5	HERC1	15	63986610	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	19095612	63986610	38544782	188	17287											
IGDCC3	9543	broad.mit.edu	37	chr15	65667661	65667661	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccctccaccctgcagtcCagcactataggctgcccggg	6	7	10	18	1	0	0	0	0	0	0	3	0	3	0	6	2	3	3	6	2	2	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:65667661C>A	uc002aos.2	-	2	435	c.183G>T	c.(181-183)CTG>CTT	p.L61L		NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	61	Extracellular (Potential).|Ig-like C2-type 1.									ovary(3)	3						CCCTGCAGTCCAGCACTATAG	0.592													9	28					3.07112e-06	3.44672e-06	1	0	A	65667661	A	A	65667661	2	1	86	1	0	0	0	0	0	0	0	1	7607	581	21	4		4	IGDCC3	15	65667661	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	1681051	65667661	36863731	189	17288											
MAP2K5	5607	broad.mit.edu	37	chr15	67873104	67873104	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctttgcagtattattccacaGtaatggaacagcaagtaaat	15	12	7	7	0	0	0	0	0	0	0	1	1	1	1	1	1	3	5	1	1	7	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:67873104G>T	uc002aqu.2	+	4	918	c.265G>T	c.(265-267)GTA>TTA	p.V89L	MAP2K5_uc002aqt.1_Missense_Mutation_p.V89L|MAP2K5_uc002aqv.2_Missense_Mutation_p.V89L|MAP2K5_uc010ujw.1_Missense_Mutation_p.V53L	NM_145160	NP_660143	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	89	OPR.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)	2						TTATTCCACAGTAATGGAACA	0.333													22	54					4.47668e-21	6.07271e-21	1	0	T	67873104	T	T	67873104	3	4	86	1	0	0	0	0	1	0	0	0	9293	1029	36	4	279	4	MAP2K5	15	67873104	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	2205443	67873104	34658288	190	17289											
ARNT2	9915	broad.mit.edu	37	chr15	80867386	80867386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggaagtccgtggaaaaggCggatgcaatcttctcccagg	10	7	14	10	3	2	0	0	0	2	0	4	3	3	3	2	5	1	1	2	5	4	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:80867386C>T	uc002bfr.2	+	14	1614	c.1448C>T	c.(1447-1449)GCG>GTG	p.A483V	ARNT2_uc010unm.1_Missense_Mutation_p.A472V|ARNT2_uc002bfs.2_Missense_Mutation_p.A472V	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	483					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			GTGGAAAAGGCGGATGCAATC	0.473													5	131					0	0	0	0	T	80867386	T	T	80867386	3	4	86	1	0	0	0	0	1	0	0	0	968	768	27	1	1502	1	ARNT2	15	80867386	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	12994282	80867386	21664006	191	17290											
SH3GL3	6457	broad.mit.edu	37	chr15	84255793	84255793	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcattagactatcacagacAgtccacagagattctgcagg	14	8	9	10	0	2	3	1	0	1	3	3	4	3	3	1	1	2	2	1	1	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:84255793A>T	uc002bjw.2	+	7	878	c.683A>T	c.(682-684)CAG>CTG	p.Q228L	SH3GL3_uc010uot.1_Missense_Mutation_p.Q228L|SH3GL3_uc002bjx.2_Missense_Mutation_p.Q159L|SH3GL3_uc002bju.2_Missense_Mutation_p.Q236L|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	228	BAR.|Interaction with ARC (By similarity).				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						TATCACAGACAGTCCACAGAG	0.502													5	17					0	0	0	0	T	84255793	T	T	84255793	3	4	86	1	0	0	0	0	1	0	0	0	14317	188	7	5	709	5	SH3GL3	15	84255793	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	3388407	84255793	18275599	192	17291											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84506852	84506852	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgttggcaggcagtgggctgCgatcggcaactgggaagcaa	9	7	17	8	2	0	0	0	0	0	0	1	2	0	1	0	5	3	6	0	5	3	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr15:84506852C>A	uc002bjz.3	+	7	836	c.612C>A	c.(610-612)TGC>TGA	p.C204*	ADAMTSL3_uc002bjy.1_Nonsense_Mutation_p.C204*|ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.C204*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.C204*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	204						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CAGTGGGCTGCGATCGGCAAC	0.567													15	62					3.27435e-08	3.91417e-08	1	0	A	84506852	A	A	84506852	4	1	86	1	0	0	0	0	0	1	0	0	276	776	27	3	634	3	ADAMTSL3	15	84506852	Nonsense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	251059	84506852	18024540	193	17292											
AXIN1	8312	broad.mit.edu	37	chr16	339603	339603	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcccaccttcctctgcgatcTtgtcctggggaaagagatgc	7	10	11	13	1	2	1	0	0	2	1	4	4	4	2	4	2	2	0	4	2	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:339603T>C	uc002cgp.1	-	10	2476	c.2299A>G	c.(2299-2301)AGA>GGA	p.R767G	AXIN1_uc002cgq.1_Missense_Mutation_p.R731G	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	767	Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CTCTGCGATCTTGTCCTGGGG	0.637													8	28					0	0	0	0	C	339603	C	C	339603	3	2	86	1	0	0	0	0	1	0	0	0	1238	1617	56	5	297	5	AXIN1	16	339603	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08		339603	90015150	194	17293											
MAPK8IP3	23162	broad.mit.edu	37	chr16	1818367	1818367	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgatgccgtgaagttctttGtctcggtgccaggtgaggct	5	12	15	9	3	2	2	0	2	2	0	3	3	2	2	2	3	2	2	2	3	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:1818367G>T	uc002cmk.2	+	30	3847	c.3727G>T	c.(3727-3729)GTC>TTC	p.V1243F	MAPK8IP3_uc002cml.2_Missense_Mutation_p.V1237F|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.V1244F	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	1243					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						GAAGTTCTTTGTCTCGGTGCC	0.652													27	60					1.5548e-18	2.08196e-18	1	0	T	1818367	T	T	1818367	3	4	86	1	0	0	0	0	1	0	0	0	9339	1377	48	4	3861	4	MAPK8IP3	16	1818367	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1478764	1818367	88536386	195	17294											
E4F1	1877	broad.mit.edu	37	chr16	2273689	2273689	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgaagccgggcgggaagcGggcgagggtgcagttgcggc	6	3	22	10	6	0	0	0	0	0	0	0	3	0	1	2	5	4	2	2	5	2	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:2273689G>A	uc002cpm.2	+	1	123	c.75G>A	c.(73-75)GCG>GCA	p.A25A	E4F1_uc010bsi.2_Silent_p.A25A|E4F1_uc010bsj.2_Silent_p.A25A	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	25					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GGCGGGAAGCGGGCGAGGGTG	0.741													4	18					0	0	0	0	A	2273689	A	A	2273689	2	1	86	1	0	0	0	0	0	0	0	1	4896	1103	39	1		1	E4F1	16	2273689	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	455322	2273689	88081064	196	17295											
ABCA3	21	broad.mit.edu	37	chr16	2333222	2333222	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccggagggcgcagaggatgcCcctgagtctctgaagcaggt	8	6	16	11	2	1	3	0	2	1	1	2	5	1	5	3	4	2	2	3	4	1	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:2333222C>A	uc002cpy.1	-	26	4712	c.4000G>T	c.(4000-4002)GGC>TGC	p.G1334C	ABCA3_uc010bsk.1_Missense_Mutation_p.G1276C	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1334					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CAGAGGATGCCCCTGAGTCTC	0.672													23	39					3.8784e-16	5.10575e-16	1	0	A	2333222	A	A	2333222	3	1	86	1	0	0	0	0	1	0	0	0	33	623	22	4	1146	4	ABCA3	16	2333222	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	59533	2333222	88021531	197	17296											
SRL	6345	broad.mit.edu	37	chr16	4242554	4242554	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaccaggagggcgtggatgCggacccggatggcgtgctgg	7	5	19	10	4	0	0	0	0	0	0	0	4	0	4	2	7	3	1	2	7	1	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:4242554C>G	uc002cvz.3	-	6	1035	c.1022G>C	c.(1021-1023)CGC>CCC	p.R341P	SRL_uc002cvy.3_RNA	NM_001098814	NP_001092284	Q86TD4	SRCA_HUMAN	sarcalumenin	800						sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5						GGCGTGGATGCGGACCCGGAT	0.512													45	138					0	0	0	0	G	4242554	G	G	4242554	3	3	86	1	0	0	0	0	1	0	0	0	15216	768	27	3	403	3	SRL	16	4242554	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	1909332	4242554	86112199	198	17297											
FAM86A	196483	broad.mit.edu	37	chr16	5143491	5143491	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccataactgacctttttGatgagttctgagagaaagca	12	12	9	8	0	1	5	0	4	1	1	1	6	1	5	2	0	3	2	2	0	2	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:5143491G>T	uc002cyo.2	-	3	283	c.234C>A	c.(232-234)ATC>ATA	p.I78I	FAM86A_uc002cyp.2_Silent_p.I78I	NM_201400	NP_958802	Q96G04	FA86A_HUMAN	hypothetical protein LOC196483 isoform 1	78											0						TGACCTTTTTGATGAGTTCTG	0.458													9	43					2.74318e-10	3.42349e-10	1	0	T	5143491	T	T	5143491	2	4	86	1	0	0	0	0	0	0	0	1	5675	1280	45	2		2	FAM86A	16	5143491	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	900937	5143491	85211262	199	17298											
RBBP6	5930	broad.mit.edu	37	chr16	24567192	24567192	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccatcttacacgtgtttccGttgtggtaaacctggacatt	8	15	8	10	2	1	0	0	0	1	0	3	1	3	1	3	2	2	3	3	2	3	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:24567192G>A	uc002dmh.2	+	6	1528	c.488G>A	c.(487-489)CGT>CAT	p.R163H	RBBP6_uc010vcb.1_Missense_Mutation_p.R30H|RBBP6_uc002dmi.2_Missense_Mutation_p.R163H|RBBP6_uc010bxr.2_Missense_Mutation_p.R163H|RBBP6_uc002dmk.2_Missense_Mutation_p.R30H	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	163	CCHC-type.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		ACGTGTTTCCGTTGTGGTAAA	0.358													10	19					0	0	0	0	A	24567192	A	A	24567192	3	1	86	1	0	0	0	0	1	0	0	0	13168	1145	40	1	564	1	RBBP6	16	24567192	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	19423701	24567192	65787561	200	17299											
CDIPT	10423	broad.mit.edu	37	chr16	29872572	29872572	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catgtccagcatggccccaaAccgggttcctggaagattag	10	8	11	12	1	0	1	0	0	0	1	2	2	2	2	5	3	2	2	5	3	3	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:29872572A>T	uc002dum.2	-	3	587	c.187T>A	c.(187-189)TTT>ATT	p.F63I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CDIPT_uc002duk.2_Missense_Mutation_p.F87I|CDIPT_uc002dul.2_Missense_Mutation_p.F35I|CDIPT_uc002dun.2_Missense_Mutation_p.F18I|LOC440356_uc010veb.1_5'Flank|LOC440356_uc002duo.2_5'Flank	NM_006319	NP_006310	O14735	CDIPT_HUMAN	CDP-diacylglycerol-inositol	63						endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|phosphatidylinositol transporter activity				0						ATGGCCCCAAACCGGGTTCCT	0.562													10	25					0	0	0	0	T	29872572	T	T	29872572	3	4	86	1	0	0	0	0	1	0	0	0	3138	43	2	5	470	5	CDIPT	16	29872572	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	5305380	29872572	60482181	201	17300											
ITGAL	3683	broad.mit.edu	37	chr16	30490651	30490651	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttgcgtctggcttctgcaGaatgtatcaagggcaacgta	9	11	11	10	2	3	1	1	0	2	1	3	1	3	1	1	2	3	5	1	2	5	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:30490651G>A	uc002dyi.3	+	6	622	c.446_splice	c.e6-1	p.E149_splice	ITGAL_uc010veu.1_Intron|ITGAL_uc002dyj.3_Intron|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor						blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GGCTTCTGCAGAATGTATCAA	0.473													23	40					0	0	0	0	A	30490651	A	A	30490651	5	1	86	1	0	0	0	0	0	0	1	0	7925	956	33	2	467	2	ITGAL	16	30490651	Splice_Site	SNP	G	TCGA-CN-6995-01A-31D-2012-08	618079	30490651	59864102	202	17301											
NLRC5	84166	broad.mit.edu	37	chr16	57067576	57067576	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctcagagcagaagcttgacGctcaggtaccttggagggat	10	8	14	9	1	2	3	2	1	0	2	2	5	2	5	1	3	3	5	1	3	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:57067576G>A	uc002ekk.1	+	12	2763	c.2538G>A	c.(2536-2538)ACG>ACA	p.T846T	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Silent_p.T595T|NLRC5_uc002ekl.2_Silent_p.T651T|NLRC5_uc002ekm.2_Silent_p.T651T|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_5'Flank	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	846					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				GAAGCTTGACGCTCAGGTACC	0.547													21	54					0	0	0	0	A	57067576	A	A	57067576	2	1	86	1	0	0	0	0	0	0	0	1	10524	1074	38	1		1	NLRC5	16	57067576	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	26576925	57067576	33287177	203	17302											
CHST6	4166	broad.mit.edu	37	chr16	75512874	75512874	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgaaggcgtagagcgcacGgatttctgccagcggctccc	8	7	14	12	4	1	2	0	1	1	1	2	3	2	3	2	3	3	3	2	3	2	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:75512874G>A	uc002fef.2	-	3	1033	c.853C>T	c.(853-855)CGT>TGT	p.R285C	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.R285C	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	285	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						TAGAGCGCACGGATTTCTGCC	0.677													6	85					0	0	0	0	A	75512874	A	A	75512874	3	1	86	1	0	0	0	0	1	0	0	0	3423	1116	39	1	338	1	CHST6	16	75512874	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	18445298	75512874	14841879	204	17303											
HSDL1	83693	broad.mit.edu	37	chr16	84163848	84163848	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgtccttcagggcttctcGaattggaaggtagatctcac	8	14	10	9	1	3	1	2	0	2	1	6	3	4	2	1	3	0	2	1	3	3	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr16:84163848G>A	uc002fhk.2	-	4	593	c.409C>T	c.(409-411)CGA>TGA	p.R137*	HSDL1_uc010vnv.1_Intron	NM_031463	NP_113651	Q3SXM5	HSDL1_HUMAN	hydroxysteroid dehydrogenase like 1 isoform a	137						mitochondrion	oxidoreductase activity|protein binding				0						AGGGCTTCTCGAATTGGAAGG	0.473													8	151					0	0	0	0	A	84163848	A	A	84163848	4	1	86	1	0	0	0	0	0	1	0	0	7432	1066	37	1	595	1	HSDL1	16	84163848	Nonsense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	8650974	84163848	6190905	205	17304											
VPS53	55275	broad.mit.edu	37	chr17	465756	465756	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gactcacttgggcaggttgcCagagaggattttccaggcgt	8	10	14	9	1	1	1	1	0	0	1	2	4	2	2	2	4	1	2	2	4	0	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:465756C>A	uc002frn.2	-	14	1690	c.1543G>T	c.(1543-1545)GGC>TGC	p.G515C	VPS53_uc002frk.2_Missense_Mutation_p.G34C|VPS53_uc010cjo.1_Missense_Mutation_p.G515C|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Missense_Mutation_p.G486C|VPS53_uc002fro.2_Missense_Mutation_p.G317C|VPS53_uc010cjp.1_Missense_Mutation_p.G238C	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	515					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		GGCAGGTTGCCAGAGAGGATT	0.478													22	59					1.85244e-09	2.25766e-09	1	0	A	465756	A	A	465756	3	1	86	1	0	0	0	0	1	0	0	0	17283	594	21	4	1006	4	VPS53	17	465756	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08		465756	80729454	206	17305											
ZZEF1	23140	broad.mit.edu	37	chr17	3926063	3926063	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttgctgcactttttcacCagcaacttcagcaaatcggt	9	13	6	13	1	2	0	2	0	0	0	3	0	2	0	2	1	5	4	2	1	2	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:3926063C>G	uc002fxe.2	-	44	7216	c.7152G>C	c.(7150-7152)CTG>CTC	p.L2384L	ZZEF1_uc002fxh.2_Silent_p.L698L|ZZEF1_uc002fxi.2_Silent_p.L619L	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2384							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACTTTTTCACCAGCAACTTCA	0.498													15	44					0	0	0	0	G	3926063	G	G	3926063	2	3	86	1	0	0	0	0	0	0	0	1	18322	581	21	4		4	ZZEF1	17	3926063	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	3460307	3926063	77269147	207	17306											
TP53	7157	broad.mit.edu	37	chr17	7576858	7576858	+	Frame_Shift_Del	DEL	G	-	-																															cccaagacttagtacctgaaGggtgaaatattctccatcca																										TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:7576858delG	uc002gim.2	-	9	1182	c.988delC	c.(988-990)CTTfs	p.L330fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.L330fs|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Frame_Shift_Del_p.L198fs|TP53_uc010cng.1_Frame_Shift_Del_p.L198fs|TP53_uc002gii.1_Frame_Shift_Del_p.L198fs|TP53_uc010cnh.1_Frame_Shift_Del_p.L330fs|TP53_uc010cni.1_Frame_Shift_Del_p.L330fs|TP53_uc002gij.2_Frame_Shift_Del_p.L330fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	330	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		L -> H (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L330H(3)|p.?(1)|p.L330P(1)|p.L330R(1)|p.L330fs*15(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGTACCTGAAGGGTGAAATAT	0.453		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7576858	-	-	7576858	7	5	86	1	0	1	0	1	0	0	0	0	16448	1000	35	0	294	0	TP53	17	7576858	Frame_Shift_Del	DEL	G	TCGA-CN-6995-01A-31D-2012-08	3650795	7576858	73618352	208	17307											
TP53	7157	broad.mit.edu	37	chr17	7577046	7577046	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgctccctgggggcagctCgtggtgaggctcccctttct	3	11	14	13	1	1	1	0	1	1	0	4	1	3	1	3	4	2	4	3	4	0	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:7577046C>A	uc002gim.2	-	8	1086	c.892G>T	c.(892-894)GAG>TAG	p.E298*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E298*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E166*|TP53_uc010cng.1_Nonsense_Mutation_p.E166*|TP53_uc002gii.1_Nonsense_Mutation_p.E166*|TP53_uc010cnh.1_Nonsense_Mutation_p.E298*|TP53_uc010cni.1_Nonsense_Mutation_p.E298*|TP53_uc002gij.2_Nonsense_Mutation_p.E298*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	298	Interaction with HIPK1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E298*(35)|p.0?(7)|p.E298K(2)|p.?(2)|p.E298V(2)|p.L299fs*2(1)|p.L265_K305del41(1)|p.E298A(1)|p.E298fs*53(1)|p.G293fs*1(1)|p.E298fs*47(1)|p.E298E(1)|p.E298Q(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGGCAGCTCGTGGTGAGGC	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	54					3.65163e-15	4.78701e-15	1	0	A	7577046	A	A	7577046	4	1	86	1	0	0	0	0	0	1	0	0	16448	893	31	3	394	3	TP53	17	7577046	Nonsense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	188	7577046	73618164	209	17308											
MYH13	8735	broad.mit.edu	37	chr17	10263357	10263357	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atactggatgacacgcttggTgttcacagtcttcccagccc	8	11	9	13	1	2	1	1	1	1	0	3	2	3	2	2	2	2	2	2	2	1	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:10263357T>C	uc002gmk.1	-	7	655	c.565A>G	c.(565-567)ACC>GCC	p.T189A		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	189	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						ACACGCTTGGTGTTCACAGTC	0.512													15	57					0	0	0	0	C	10263357	C	C	10263357	3	2	86	1	0	0	0	0	1	0	0	0	10085	1696	59	5	5391	5	MYH13	17	10263357	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	2686311	10263357	70931853	210	17309											
MYH3	4621	broad.mit.edu	37	chr17	10535187	10535187	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggagctcctgttccgccagTttccgggccctctccgtctg	3	11	11	16	3	2	0	0	0	2	0	6	1	5	1	6	2	1	3	6	2	0	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:10535187T>A	uc002gmq.1	-	34	5180	c.5103A>T	c.(5101-5103)AAA>AAT	p.K1701N		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1701	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						GTTCCGCCAGTTTCCGGGCCC	0.637													10	61					0	0	0	0	A	10535187	A	A	10535187	3	1	86	1	0	0	0	0	1	0	0	0	10089	1722	60	5	747	5	MYH3	17	10535187	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	271830	10535187	70660023	211	17310											
ELAC2	60528	broad.mit.edu	37	chr17	12905653	12905653	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattcaccctgaaccatgggCacactgagggtggggccctc	8	7	12	14	0	1	2	1	2	0	0	2	2	1	2	3	4	1	1	3	4	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:12905653C>A	uc002gnz.3	-	14	1337	c.1242G>T	c.(1240-1242)GTG>GTT	p.V414V	ELAC2_uc002gnu.3_5'Flank|ELAC2_uc002gnv.3_Silent_p.V42V|ELAC2_uc002gnw.3_Silent_p.V72V|ELAC2_uc002gnx.3_Silent_p.V174V|ELAC2_uc010vvo.1_Silent_p.V212V|ELAC2_uc010vvp.1_Silent_p.V395V|ELAC2_uc010vvq.1_Silent_p.V413V|ELAC2_uc010vvr.1_Silent_p.V374V	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	elaC homolog 2 isoform 1	414					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding				0						GAACCATGGGCACACTGAGGG	0.562									Hereditary_Prostate_Cancer				21	54					1.28384e-07	1.50586e-07	1	0	A	12905653	A	A	12905653	2	1	86	1	0	0	0	0	0	0	0	1	5071	697	25	4		4	ELAC2	17	12905653	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	2370466	12905653	68289557	212	17311											
MYO18A	399687	broad.mit.edu	37	chr17	27447762	27447762	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttccaggagggtgtacagagCctgccacttctccactgcag	8	9	11	13	0	1	1	0	0	1	1	3	2	2	2	4	2	4	2	4	2	1	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:27447762C>T	uc002hdt.1	-	7	1758	c.1600G>A	c.(1600-1602)GCT>ACT	p.A534T	MYO18A_uc010wbc.1_Missense_Mutation_p.A76T|MYO18A_uc002hds.2_Missense_Mutation_p.A76T|MYO18A_uc010csa.1_Missense_Mutation_p.A534T|MYO18A_uc002hdu.1_Missense_Mutation_p.A534T|MYO18A_uc010wbd.1_Missense_Mutation_p.A203T	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	534	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GTGTACAGAGCCTGCCACTTC	0.567													25	49					0	0	0	0	T	27447762	T	T	27447762	3	4	86	1	0	0	0	0	1	0	0	0	10118	739	26	4	4708	4	MYO18A	17	27447762	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	14542109	27447762	53747448	213	17312											
KRT28	162605	broad.mit.edu	37	chr17	38948796	38948796	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctagctcttcaaccactgtCtttaccagtgtggttttgga	7	16	8	10	0	4	0	1	0	3	0	4	1	4	1	2	2	3	2	2	2	3	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:38948796C>A	uc002hvh.1	-	8	1344	c.1278G>T	c.(1276-1278)AAG>AAT	p.K426N		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	426	Tail.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CAACCACTGTCTTTACCAGTG	0.348													10	25					3.86212e-05	4.21322e-05	1	0	A	38948796	A	A	38948796	3	1	86	1	0	0	0	0	1	0	0	0	8504	912	32	2	120	2	KRT28	17	38948796	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	11501034	38948796	42246414	214	17313											
CDK5RAP3	80279	broad.mit.edu	37	chr17	46051295	46051295	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatcccgtctcttgctttctAgacattcactactttcactg	8	16	4	13	1	4	1	2	0	2	1	6	1	5	1	1	0	2	1	1	0	3	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:46051295A>G	uc002imr.2	+	4	269	c.185_splice	c.e4-2	p.Y62_splice	CDK5RAP3_uc010wlc.1_Splice_Site_p.Y82_splice|CDK5RAP3_uc002imq.1_Splice_Site|CDK5RAP3_uc002imu.2_Splice_Site|CDK5RAP3_uc002ims.2_Splice_Site|CDK5RAP3_uc002imv.2_Splice_Site|CDK5RAP3_uc002imw.2_Splice_Site|CDK5RAP3_uc002imx.2_Splice_Site	NM_176096	NP_788276	Q96JB5	CK5P3_HUMAN	CDK5 regulatory subunit associated protein 3						brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding				0						CTTGCTTTCTAGACATTCACT	0.443													35	115					0	0	0	0	G	46051295	G	G	46051295	5	3	86	1	0	0	0	0	0	0	1	0	3162	434	15	5	197	5	CDK5RAP3	17	46051295	Splice_Site	SNP	A	TCGA-CN-6995-01A-31D-2012-08	7102499	46051295	35143915	215	17314											
SDK2	54549	broad.mit.edu	37	chr17	71390387	71390387	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgttgcgatcagcctcgggGacctcgctccagcgcaccag	6	6	12	17	5	1	0	1	0	0	0	4	2	2	1	5	2	3	3	5	2	0	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:71390387G>A	uc010dfm.2	-	26	3669	c.3669C>T	c.(3667-3669)GTC>GTT	p.V1223V	SDK2_uc002jjt.3_Silent_p.V382V|SDK2_uc010dfn.2_Silent_p.V902V	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1223	Fibronectin type-III 7.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						CAGCCTCGGGGACCTCGCTCC	0.652													5	19					0	0	0	0	A	71390387	A	A	71390387	2	1	86	1	0	0	0	0	0	0	0	1	14034	1161	41	2		2	SDK2	17	71390387	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	25339092	71390387	9804823	216	17315											
MGAT5B	146664	broad.mit.edu	37	chr17	74901400	74901400	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagctgggggccacccaGagggaccagaagcaggtgcg	11	2	17	11	1	0	3	0	0	0	3	0	4	0	4	3	4	3	2	3	4	2	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr17:74901400G>T	uc002jti.2	+	6	976	c.873G>T	c.(871-873)CAG>CAT	p.Q291H	MGAT5B_uc002jth.2_Missense_Mutation_p.Q280H	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	280	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						GGGCCACCCAGAGGGACCAGA	0.627													12	35					5.16669e-11	6.52634e-11	1	0	T	74901400	T	T	74901400	3	4	86	1	0	0	0	0	1	0	0	0	9602	933	33	2	967	2	MGAT5B	17	74901400	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	3511013	74901400	6293810	217	17316											
CIDEA	1149	broad.mit.edu	37	chr18	12262964	12262964	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcctgcaggagctcatcaGcaaggtgccccacatcccgc	9	5	10	17	1	2	0	2	0	0	0	3	1	3	1	4	2	5	3	4	2	1	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr18:12262964G>T	uc002kqt.3	+	2	244	c.179G>T	c.(178-180)AGC>ATC	p.S60I	CIDEA_uc002kqu.3_Missense_Mutation_p.S94I|CIDEA_uc010dlc.2_RNA	NM_001279	NP_001270	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a isoform	60	CIDE-N.				DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			ovary(1)|central_nervous_system(1)	2						GAGCTCATCAGCAAGGTGCCC	0.642													8	26					0.00307968	0.00329062	1	0	T	12262964	T	T	12262964	3	4	86	1	0	0	0	0	1	0	0	0	3440	971	34	4	329	4	CIDEA	18	12262964	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08		12262964	65814284	218	17317											
MC2R	4158	broad.mit.edu	37	chr18	13884633	13884633	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gatcagccattctaccagtaCctgctgcagaagatcatctt	11	11	7	12	0	4	2	2	0	2	2	4	3	4	2	3	0	5	3	3	0	3	4	rs147683219		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr18:13884633C>G	uc002ksp.1	-	2	1062	c.885G>C	c.(883-885)AGG>AGC	p.R295S		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	295	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	TCTACCAGTACCTGCTGCAGA	0.478													18	57					0	0	0	0	G	13884633	G	G	13884633	3	3	86	1	0	0	0	0	1	0	0	0	9417	506	18	4	12	4	MC2R	18	13884633	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	1621669	13884633	64192615	219	17318											
TCEB3B	51224	broad.mit.edu	37	chr18	44559713	44559713	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccacagatttgaaacagatCatctttgcctctctgccgtt	9	13	7	12	1	3	3	1	1	2	2	4	3	3	3	3	0	3	1	3	0	1	3	rs143582553		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr18:44559713C>T	uc002lcr.1	-	1	2276	c.1923G>A	c.(1921-1923)ATG>ATA	p.M641I	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	641	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TGAAACAGATCATCTTTGCCT	0.537													68	80					0	0	0	0	T	44559713	T	T	44559713	3	4	86	1	0	0	0	0	1	0	0	0	15748	826	29	2	342	2	TCEB3B	18	44559713	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	30675080	44559713	33517535	220	17319											
DCC	1630	broad.mit.edu	37	chr18	50450075	50450075	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atactgtgttttcccctcatAgatccaggactgcatagaca	11	12	7	11	0	1	2	1	0	0	2	3	3	3	3	3	1	2	2	3	1	3	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr18:50450075A>G	uc002lfe.1	+	4	1285	c.698_splice	c.e4-2	p.D233_splice	DCC_uc010xdr.1_Splice_Site_p.D81_splice	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor						apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TTCCCCTCATAGATCCAGGAC	0.343													14	18					0	0	0	0	G	50450075	G	G	50450075	5	3	86	1	0	0	0	0	0	0	1	0	4299	434	15	5	710	5	DCC	18	50450075	Splice_Site	SNP	A	TCGA-CN-6995-01A-31D-2012-08	5890362	50450075	27627173	221	17320											
MUC16	94025	broad.mit.edu	37	chr19	9062563	9062563	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gttgagaagagaagtcacagGaagagaagcggaagggaaat	18	4	16	3	1	1	3	1	1	0	3	1	9	1	6	0	3	1	1	0	3	6	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:9062563G>A	uc002mkp.2	-	3	25087	c.24883C>T	c.(24883-24885)CCT>TCT	p.P8295S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8297	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAGTCACAGGAAGAGAAGCG	0.512													22	50					0	0	0	0	A	9062563	A	A	9062563	3	1	86	1	0	0	0	0	1	0	0	0	10026	1174	41	2	18968	2	MUC16	19	9062563	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08		9062563	50066420	222	17321											
MUC16	94025	broad.mit.edu	37	chr19	9086084	9086084	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggagctgaggtctcaggtcGgggatggattgaagaagaca	12	7	17	5	1	1	4	1	2	1	2	3	7	1	7	0	6	1	1	0	6	2	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:9086084G>A	uc002mkp.2	-	1	5935	c.5731C>T	c.(5731-5733)CGA>TGA	p.R1911*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1911	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCTCAGGTCGGGGATGGATT	0.488													11	27					0	0	0	0	A	9086084	A	A	9086084	4	1	86	1	0	0	0	0	0	1	0	0	10026	1124	39	1	38128	1	MUC16	19	9086084	Nonsense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	23521	9086084	50042899	223	17322											
OR7G2	390882	broad.mit.edu	37	chr19	9213532	9213532	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgatgactgtgtatctaaGggggtgacaaatggccacat	12	10	12	7	0	1	3	0	3	1	0	1	3	1	3	1	3	0	1	1	3	3	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:9213532G>T	uc010xkk.1	-	1	451	c.451C>A	c.(451-453)CTT>ATT	p.L151I		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GTGTATCTAAGGGGGTGACAA	0.498													15	28					1.05317e-09	1.28858e-09	1	0	T	9213532	T	T	9213532	3	4	86	1	0	0	0	0	1	0	0	0	11277	1000	35	4	588	4	OR7G2	19	9213532	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	127448	9213532	49915451	224	17323											
CARM1	10498	broad.mit.edu	37	chr19	11018818	11018818	+	Frame_Shift_Del	DEL	C	-	-																															tcttctgccgtgcagtacttCcaggtgggttgtactccccc																										TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:11018818delC	uc002mpz.2	+	3	576	c.450delC	c.(448-450)TTCfs	p.F150fs	CARM1_uc010dxn.2_RNA	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	150					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						TGCAGTACTTCCAGGTGGGTT	0.612													---	---	---								-	11018818	-	-	11018818	7	5	86	1	0	1	0	1	0	0	0	0	2667	854	30	0	460	0	CARM1	19	11018818	Frame_Shift_Del	DEL	C	TCGA-CN-6995-01A-31D-2012-08	1805286	11018818	48110165	225	17324											
ZNF563	147837	broad.mit.edu	37	chr19	12433432	12433432	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcctgatggtttcttgcaTcacatatctgtataaattct	9	18	6	8	0	4	1	1	1	3	0	5	1	5	1	1	1	1	4	1	1	4	7			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:12433432T>C	uc002mtp.2	-	2	335	c.97A>G	c.(97-99)ATG>GTG	p.M33V	ZNF563_uc002mtq.2_Missense_Mutation_p.M33V	NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	33	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTTTCTTGCATCACATATCTG	0.433													24	49					0	0	0	0	C	12433432	C	C	12433432	3	2	86	1	0	0	0	0	1	0	0	0	18061	1435	50	5	1345	5	ZNF563	19	12433432	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	1414614	12433432	46695551	226	17325											
MEF2B	100271849	broad.mit.edu	37	chr19	19258514	19258514	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagtcacttacatacagcCggggtcggggcaaggccgga	9	5	17	10	3	1	0	1	0	0	0	2	2	1	2	2	7	3	1	2	7	3	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:19258514C>A	uc002nlm.2	-	4	500	c.386G>T	c.(385-387)CGG>CTG	p.R129L	MEF2B_uc002nln.2_Missense_Mutation_p.R176L|MEF2B_uc002nll.2_Missense_Mutation_p.R129L|LOC729991-MEF2B_uc010xqo.1_Missense_Mutation_p.R129L|LOC729991-MEF2B_uc010xqp.1_Missense_Mutation_p.R129L|LOC729991-MEF2B_uc002nlo.2_Missense_Mutation_p.R129L|LOC729991-MEF2B_uc002nlp.2_Missense_Mutation_p.R129L|MEF2B_uc002nlk.2_Missense_Mutation_p.R132L	NM_001145785	NP_001139257			myocyte enhancer factor 2B isoform a											skin(1)	1			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)			TACATACAGCCGGGGTCGGGG	0.577													19	45					8.34094e-07	9.5325e-07	1	0	A	19258514	A	A	19258514	3	1	86	1	0	0	0	0	1	0	0	0	9509	652	23	3	744	3	MEF2B	19	19258514	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	6825082	19258514	39870469	227	17326											
RYR1	6261	broad.mit.edu	37	chr19	38976617	38976617	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accacttcgctgaggcccccGcatcatttctcgcccccctg	5	9	7	20	3	2	1	1	1	1	0	4	1	2	1	6	1	0	2	6	1	0	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:38976617G>A	uc002oit.2	+	34	5452	c.5322G>A	c.(5320-5322)CCG>CCA	p.P1774P	RYR1_uc002oiu.2_Silent_p.P1774P	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1774	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGAGGCCCCCGCATCATTTCT	0.692													8	81					0	0	0	0	A	38976617	A	A	38976617	2	1	86	1	0	0	0	0	0	0	0	1	13833	1074	38	1		1	RYR1	19	38976617	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	19718103	38976617	20152366	228	17327											
MAP4K1	11184	broad.mit.edu	37	chr19	39100273	39100273	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatccccagagagctggaGcggtgggtggatctgatccg	7	7	18	9	2	1	2	0	1	1	1	3	6	3	5	3	5	2	1	3	5	0	0			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:39100273G>C	uc002oix.1	-	13	1077	c.969C>G	c.(967-969)CGC>CGG	p.R323R	MAP4K1_uc002oiw.1_5'Flank|MAP4K1_uc002oiy.1_Silent_p.R323R|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	323					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GAGAGCTGGAGCGGTGGGTGG	0.592													8	29					0	0	0	0	C	39100273	C	C	39100273	2	2	86	1	0	0	0	0	0	0	0	1	9312	958	34	4		4	MAP4K1	19	39100273	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	123656	39100273	20028710	229	17328											
SPTBN4	57731	broad.mit.edu	37	chr19	41062929	41062929	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccccacttcctgatggcagGtgctgcaggagaaattctca	9	9	10	13	0	1	2	1	1	1	1	3	3	2	2	3	3	2	3	3	3	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:41062929G>T	uc002ony.2	+	26	5376	c.5290G>T	c.(5290-5292)GTG>TTG	p.V1764L	SPTBN4_uc002onx.2_Missense_Mutation_p.V1764L|SPTBN4_uc002onz.2_Missense_Mutation_p.V1764L|SPTBN4_uc010egx.2_Missense_Mutation_p.V507L|SPTBN4_uc002ooa.2_Missense_Mutation_p.V440L	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1764	Spectrin 15.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGATGGCAGGTGCTGCAGGA	0.532													8	31					1.12685e-05	1.25117e-05	1	0	T	41062929	T	T	41062929	3	4	86	1	0	0	0	0	1	0	0	0	15187	1275	44	4	5388	4	SPTBN4	19	41062929	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	1962656	41062929	18066054	230	17329											
ZNF230	7773	broad.mit.edu	37	chr19	44515025	44515025	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataattcatactggggagaaGccgttcaaatgtgaaatatg	15	11	10	5	1	2	2	2	1	0	1	2	3	2	2	1	2	2	1	1	2	6	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:44515025G>A	uc002oyb.1	+	5	1085	c.834G>A	c.(832-834)AAG>AAA	p.K278K		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CTGGGGAGAAGCCGTTCAAAT	0.423													21	94					0	0	0	0	A	44515025	A	A	44515025	2	1	86	1	0	0	0	0	0	0	0	1	17851	962	34	4		4	ZNF230	19	44515025	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	3452096	44515025	14613958	231	17330											
PNMAL1	55228	broad.mit.edu	37	chr19	46973549	46973549	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgcttcctgcctggagttCttcttctgcttctttctcct	2	19	6	14	0	5	0	0	0	5	0	7	1	6	1	3	1	3	3	3	1	0	6			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:46973549C>T	uc002peq.3	-	2	1050	c.744G>A	c.(742-744)AAG>AAA	p.K248K	PNMAL1_uc002per.3_Silent_p.K248K	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	248											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GCCTGGAGTTCTTCTTCTGCT	0.522													20	142					0	0	0	0	T	46973549	T	T	46973549	2	4	86	1	0	0	0	0	0	0	0	1	12212	912	32	2		2	PNMAL1	19	46973549	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	2458524	46973549	12155434	232	17331											
GLTSCR1	29998	broad.mit.edu	37	chr19	48202269	48202269	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagctgctgaaacgcaccCaggccatgctcaataaatat	13	7	8	13	2	1	1	1	1	0	0	1	1	1	1	2	1	4	5	2	1	5	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:48202269C>T	uc002phh.3	+	13	3639	c.3445C>T	c.(3445-3447)CAG>TAG	p.Q1149*	GLTSCR1_uc002phi.3_Nonsense_Mutation_p.Q907*	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	1149							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		GAAACGCACCCAGGCCATGCT	0.632											OREG0025594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	7					0	0	0	0	T	48202269	T	T	48202269	4	4	86	1	0	0	0	0	0	1	0	0	6511	595	21	4	3487	4	GLTSCR1	19	48202269	Nonsense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	1228720	48202269	10926714	233	17332											
PLA2G4C	8605	broad.mit.edu	37	chr19	48601480	48601480	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtagtgtcccttcttccaCgggcttcttcatattggaca	6	14	10	11	1	3	0	1	0	2	0	5	1	5	1	2	3	0	2	2	3	2	7			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:48601480C>A	uc002phx.2	-	6	882	c.484G>T	c.(484-486)GTG>TTG	p.V162L	PLA2G4C_uc002phw.2_Missense_Mutation_p.V97L|PLA2G4C_uc010elr.2_Missense_Mutation_p.V162L|PLA2G4C_uc010xzd.1_Missense_Mutation_p.V172L|PLA2G4C_uc002phy.3_Missense_Mutation_p.V162L	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	162	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CCTTCTTCCACGGGCTTCTTC	0.527													27	82					1.75199e-13	2.25876e-13	1	0	A	48601480	A	A	48601480	3	1	86	1	0	0	0	0	1	0	0	0	12058	536	19	3	1193	3	PLA2G4C	19	48601480	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	399211	48601480	10527503	234	17333											
PRR12	57479	broad.mit.edu	37	chr19	50098459	50098459	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacgccaggacacggtcatCaagcactaccagcggccagc	11	3	10	17	3	2	0	2	0	0	0	2	1	2	1	4	3	4	1	4	3	2	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:50098459C>T	uc002poo.3	+	4	867	c.867C>T	c.(865-867)ATC>ATT	p.I289I		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		ACACGGTCATCAAGCACTACC	0.697													5	12					0	0	0	0	T	50098459	T	T	50098459	2	4	86	1	0	0	0	0	0	0	0	1	12646	816	29	2		2	PRR12	19	50098459	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	1496979	50098459	9030524	235	17334											
ZNF665	79788	broad.mit.edu	37	chr19	53668172	53668172	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagttaggcttgaatgaacaCtaaaggctttgccacactca	13	11	8	9	0	1	2	1	2	0	0	1	2	1	2	1	2	2	3	1	2	6	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:53668172C>A	uc010eqm.1	-	4	1671	c.1571G>T	c.(1570-1572)AGT>ATT	p.S524I		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	459	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TGAATGAACACTAAAGGCTTT	0.393													47	121					1.6237e-14	2.11964e-14	1	0	A	53668172	A	A	53668172	3	1	86	1	0	0	0	0	1	0	0	0	18140	565	20	4	469	4	ZNF665	19	53668172	Missense_Mutation	SNP	C	TCGA-CN-6995-01A-31D-2012-08	3569713	53668172	5460811	236	17335											
MBOAT7	79143	broad.mit.edu	37	chr19	54677883	54677883	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaagtagatggaggcccagTaccgaagggtgtcggccaag	12	5	16	8	2	0	2	0	0	0	2	1	4	0	3	3	4	1	2	3	4	5	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr19:54677883T>G	uc002qdq.2	-	9	1540	c.1274A>C	c.(1273-1275)TAC>TCC	p.Y425S	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Missense_Mutation_p.Y109S|MBOAT7_uc010yem.1_Missense_Mutation_p.Y407S|MBOAT7_uc002qdr.2_Missense_Mutation_p.Y425S|MBOAT7_uc002qds.2_Missense_Mutation_p.Y352S|MBOAT7_uc010yen.1_Missense_Mutation_p.Y352S	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	425					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGAGGCCCAGTACCGAAGGGT	0.637													18	103					0	0	0	0	G	54677883	G	G	54677883	3	3	86	1	0	0	0	0	1	0	0	0	9411	1638	57	5	148	5	MBOAT7	19	54677883	Missense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	1009711	54677883	4451100	237	17336											
PLCB1	23236	broad.mit.edu	37	chr20	8741079	8741079	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaaggcacctgccaaaacAgaagatcttattcagagtgt	15	9	9	8	0	2	3	1	0	1	3	2	3	2	3	2	1	2	2	2	1	6	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr20:8741079A>G	uc002wnb.2	+	25	2685	c.2682A>G	c.(2680-2682)ACA>ACG	p.T894T	PLCB1_uc010zrb.1_Silent_p.T793T|PLCB1_uc002wna.2_Silent_p.T894T|PLCB1_uc002wnc.1_Silent_p.T793T|PLCB1_uc002wnd.1_Silent_p.T471T	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	894					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CTGCCAAAACAGAAGATCTTA	0.358													5	14					0	0	0	0	G	8741079	G	G	8741079	2	3	86	1	0	0	0	0	0	0	0	1	12082	175	7	5		5	PLCB1	20	8741079	Silent	SNP	A	TCGA-CN-6995-01A-31D-2012-08		8741079	54284441	238	17337											
CHD6	84181	broad.mit.edu	37	chr20	40033381	40033381	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgggagcaggctctgggtggGagttggggttgtcccccttt	3	12	18	8	0	1	0	0	0	1	0	2	2	2	2	2	6	1	4	2	6	0	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr20:40033381G>A	uc002xka.1	-	37	8178	c.8000C>T	c.(7999-8001)TCC>TTC	p.S2667F	CHD6_uc002xjz.1_Missense_Mutation_p.S204F	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2667					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CTCTGGGTGGGAGTTGGGGTT	0.587													35	101					0	0	0	0	A	40033381	A	A	40033381	3	1	86	1	0	0	0	0	1	0	0	0	3344	1174	41	2	151	2	CHD6	20	40033381	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	31292302	40033381	22992139	239	17338											
PTPN1	5770	broad.mit.edu	37	chr20	49195149	49195149	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggaaccttctgtctggctGatacctgcctcttgctggta	5	14	10	12	0	3	1	0	1	3	0	3	2	3	2	3	3	4	3	3	3	3	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr20:49195149G>A	uc002xvl.2	+	6	859	c.685G>A	c.(685-687)GAT>AAT	p.D229N	PTPN1_uc010zys.1_Missense_Mutation_p.D156N	NM_002827	NP_002818	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type	229	Tyrosine-protein phosphatase.				blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding				0		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	CTGTCTGGCTGATACCTGCCT	0.587													7	44					0	0	0	0	A	49195149	A	A	49195149	3	1	86	1	0	0	0	0	1	0	0	0	12842	1290	45	2	707	2	PTPN1	20	49195149	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	9161768	49195149	13830371	240	17339											
CASS4	57091	broad.mit.edu	37	chr20	55026880	55026880	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggttctcccacaggggcaGggtgttcccctgatatcagt	6	11	13	11	0	2	1	1	1	1	0	4	1	3	1	3	4	0	3	3	4	1	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr20:55026880G>T	uc002xxp.2	+	6	873	c.648G>T	c.(646-648)CAG>CAT	p.Q216H	CASS4_uc002xxq.3_Missense_Mutation_p.Q216H|CASS4_uc002xxr.2_Missense_Mutation_p.Q216H|CASS4_uc010zze.1_Missense_Mutation_p.Q162H|CASS4_uc010gio.2_Intron	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	216					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						CACAGGGGCAGGGTGTTCCCC	0.502													18	48					1.00905e-13	1.30632e-13	1	0	T	55026880	T	T	55026880	3	4	86	1	0	0	0	0	1	0	0	0	2695	991	35	4	666	4	CASS4	20	55026880	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	5831731	55026880	7998640	241	17340											
SAMSN1	64092	broad.mit.edu	37	chr21	15870786	15870786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttcttcaaggaagttttcaGcagctgatagtaaccttctt	10	15	7	9	0	4	1	2	1	2	0	4	2	4	2	1	1	3	4	1	1	4	8			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:15870786G>A	uc002yju.1	-	7	978	c.896C>T	c.(895-897)GCT>GTT	p.A299V	SAMSN1_uc010gky.1_Missense_Mutation_p.A131V|SAMSN1_uc002yjv.1_Missense_Mutation_p.A367V	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	299	SAM.				negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		GAAGTTTTCAGCAGCTGATAG	0.338													12	33					0	0	0	0	A	15870786	A	A	15870786	3	1	86	1	0	0	0	0	1	0	0	0	13895	971	34	4	233	4	SAMSN1	21	15870786	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08		15870786	32259109	242	17341											
C21orf91	54149	broad.mit.edu	37	chr21	19165780	19165781	+	Frame_Shift_Ins	INS	-	A	A																															ttcctgttcgccctacttgcINSagacatggtaacttagaaca																										TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:19165780_19165781insA	uc002yko.3	-	5	936_937	c.845_846insT	c.(844-846)CTGfs	p.L282fs	C21orf91_uc002ykm.2_5'Flank|C21orf91_uc002ykn.2_5'Flank|C21orf91_uc002ykq.3_Frame_Shift_Ins_p.L281fs|C21orf91_uc002ykp.3_3'UTR	NM_001100420	NP_001093890	Q9NYK6	EURL_HUMAN	early undifferentiated retina and lens isoform	282										ovary(1)	1				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)		GCCCTACTTGCAGACATGGTAA	0.475													---	---	---								A	19165781	A	A	19165780	7	5	86	1	0	1	1	0	0	0	0	0	2144	697	25	0	51	0	C21orf91	21	19165780	Frame_Shift_Ins	INS	-	TCGA-CN-6995-01A-31D-2012-08	3294994	19165780	28964115	243	17342											
TIAM1	7074	broad.mit.edu	37	chr21	32582412	32582412	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcgcctggccggacgacCgtcagggcaggctgattatt	6	9	15	11	4	1	1	1	1	0	0	2	3	1	2	3	4	0	2	3	4	1	2	rs28520154		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:32582412C>G	uc002yow.1	-	12	2809	c.2337G>C	c.(2335-2337)ACG>ACC	p.T779T	TIAM1_uc011adk.1_Silent_p.T779T|TIAM1_uc011adl.1_Silent_p.T754T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	779	RBD.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GCCGGACGACCGTCAGGGCAG	0.547													12	40					0	0	0	0	G	32582412	G	G	32582412	2	3	86	1	0	0	0	0	0	0	0	1	15956	639	23	3		3	TIAM1	21	32582412	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	13416632	32582412	15547483	244	17343											
TIAM1	7074	broad.mit.edu	37	chr21	32638554	32638554	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctccccggccccccgttTgctgtcactccagagttttt	3	14	8	16	2	1	1	1	0	0	1	3	1	3	1	6	1	2	4	6	1	0	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:32638554T>G	uc002yow.1	-	5	1207	c.735A>C	c.(733-735)GCA>GCC	p.A245A	TIAM1_uc011adk.1_Silent_p.A245A|TIAM1_uc011adl.1_Silent_p.A245A|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	245					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GCCCCCCGTTTGCTGTCACTC	0.547													25	80					0	0	0	0	G	32638554	G	G	32638554	2	3	86	1	0	0	0	0	0	0	0	1	15956	1799	63	5		5	TIAM1	21	32638554	Silent	SNP	T	TCGA-CN-6995-01A-31D-2012-08	56142	32638554	15491341	245	17344											
TRPM2	7226	broad.mit.edu	37	chr21	45815335	45815335	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtccctctacaagcgttcCtcaggccatgtgaccttcac	7	10	8	16	2	3	1	2	1	1	0	5	1	5	1	4	2	2	1	4	2	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr21:45815335C>A	uc002zet.1	+	13	2046	c.1833C>A	c.(1831-1833)TCC>TCA	p.S611S	TRPM2_uc002zeu.1_Silent_p.S611S|TRPM2_uc002zew.1_Silent_p.S611S|TRPM2_uc010gpt.1_Silent_p.S611S|TRPM2_uc002zex.1_Silent_p.S397S|TRPM2_uc002zey.1_Silent_p.S124S	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	611	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACAAGCGTTCCTCAGGCCATG	0.502													11	139					4.3838e-07	5.08456e-07	1	0	A	45815335	A	A	45815335	2	1	86	1	0	0	0	0	0	0	0	1	16653	668	24	4		4	TRPM2	21	45815335	Silent	SNP	C	TCGA-CN-6995-01A-31D-2012-08	13176781	45815335	2314560	246	17345											
GNAZ	2781	broad.mit.edu	37	chr22	23438557	23438557	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcacagccatcatcttctgTgtggagctcagcggctacga	8	10	11	12	2	5	0	3	0	2	0	5	2	5	1	1	2	4	2	1	2	1	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr22:23438557T>C	uc002zwu.1	+	2	1212	c.675T>C	c.(673-675)TGT>TGC	p.C225C	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	225						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		TCATCTTCTGTGTGGAGCTCA	0.567													44	205					0	0	0	0	C	23438557	C	C	23438557	2	2	86	1	0	0	0	0	0	0	0	1	6551	1702	59	5		5	GNAZ	22	23438557	Silent	SNP	T	TCGA-CN-6995-01A-31D-2012-08		23438557	27866009	247	17346											
SEC14L4	284904	broad.mit.edu	37	chr22	30887558	30887558	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagtaaaccccgcagctcttAcagacgccagcctggaggca	11	5	10	15	2	1	1	0	0	1	1	1	2	1	2	4	2	4	4	4	2	3	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chr22:30887558A>G	uc003aid.2	-	11	1181	c.1081_splice	c.e11+1	p.Y361_splice	SEC14L4_uc011akz.1_Splice_Site_p.*361_splice|SEC14L4_uc003aie.2_Splice_Site_p.Y346_splice|SEC14L4_uc003aif.2_Splice_Site_p.Y307_splice	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a							integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	CGCAGCTCTTACAGACGCCAG	0.602													11	62					0	0	0	0	G	30887558	G	G	30887558	5	3	86	1	0	0	0	0	0	0	1	0	14049	405	14	5	151	5	SEC14L4	22	30887558	Splice_Site	SNP	A	TCGA-CN-6995-01A-31D-2012-08	7449001	30887558	20417008	248	17347											
FAM9A	171482	broad.mit.edu	37	chrX	8764319	8764320	+	Frame_Shift_Ins	INS	-	T	T																															caatcatacctttttagttgINStttttttttcaaagcacgtt																								rs1985393		TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:8764319_8764320insT	uc004csg.2	-	6	588_589	c.477_478insA	c.(475-480)AAACAAfs	p.K159fs		NM_174951	NP_777611	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	159_160						nucleolus					0		Hepatocellular(5;0.219)				CTTTTTAGTTGTTTTTTTTTCA	0.292													---	---	---								T	8764320	T	T	8764319	7	5	86	1	0	1	1	0	0	0	0	0	5691	1386	48	0	536	0	FAM9A	23	8764319	Frame_Shift_Ins	INS	-	TCGA-CN-6995-01A-31D-2012-08		8764319	146506241	249	17348											
GLRA2	2742	broad.mit.edu	37	chrX	14708939	14708939	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcgtctccaggcaacacaaGgagttcctgcgcctccgaag	9	8	10	14	3	1	0	0	0	1	0	5	2	3	1	4	2	2	2	4	2	3	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:14708939G>A	uc010nep.2	+	9	1370	c.1038G>A	c.(1036-1038)AAG>AAA	p.K346K	GLRA2_uc010neq.2_Silent_p.K346K|GLRA2_uc004cwe.3_Silent_p.K346K|GLRA2_uc011mio.1_Silent_p.K257K|GLRA2_uc011mip.1_Silent_p.K324K	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	346	Cytoplasmic (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	GGCAACACAAGGAGTTCCTGC	0.488													21	19					0	0	0	0	A	14708939	A	A	14708939	2	1	86	1	0	0	0	0	0	0	0	1	6492	991	35	4		4	GLRA2	23	14708939	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	5944620	14708939	140561621	250	17349											
APOO	79135	broad.mit.edu	37	chrX	23897090	23897091	+	Frame_Shift_Ins	INS	-	GCTGGCTC	GCTGGCTC																															ctgtgagatgctttcttcaaINSgctggctccttgcctcctcc																										TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:23897090_23897091insGCTGGCTC	uc004dax.2	-	3	409_410	c.178_179insGAGCCAGC	c.(178-180)CTTfs	p.L60fs	APOO_uc004daw.2_RNA|APOO_uc004day.3_RNA	NM_024122	NP_077027	Q9BUR5	APOO_HUMAN	apolipoprotein O precursor	60					lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle					0						GCTTTCTTCAAGCTGGCTCCTT	0.441													---	---	---								GCTGGCTC	23897091	GCTGGCTC	GCTGGCTC	23897090	7	5	86	1	0	1	1	0	0	0	0	0	813	72	3	0	441	0	APOO	23	23897090	Frame_Shift_Ins	INS	-	TCGA-CN-6995-01A-31D-2012-08	9188151	23897090	131373470	251	17350											
ZXDA	7789	broad.mit.edu	37	chrX	57934507	57934507	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taagatttctttctttctgaGaaccatggtttcctgctgca	8	17	7	9	0	3	2	0	1	3	2	4	3	4	2	2	1	3	3	2	1	2	5			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:57934507G>C	uc004dve.2	-	1	2561	c.2348C>G	c.(2347-2349)TCT>TGT	p.S783C		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	783					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TTCTTTCTGAGAACCATGGTT	0.448													25	16					0	0	0	0	C	57934507	C	C	57934507	3	2	86	1	0	0	0	0	1	0	0	0	18317	942	33	2	55	2	ZXDA	23	57934507	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	34037417	57934507	97336053	252	17351											
TAF1	6872	broad.mit.edu	37	chrX	70612767	70612767	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaagaagacagtgacaggaAcagatgcagaccttcgtcgc	14	6	12	9	2	0	6	0	2	0	4	2	7	0	7	1	1	2	1	1	1	3	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:70612767A>G	uc004dzu.3	+	20	3022	c.2971A>G	c.(2971-2973)ACA>GCA	p.T991A	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.T1012A|TAF1_uc004dzv.3_Missense_Mutation_p.T165A	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	991					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AGTGACAGGAACAGATGCAGA	0.428													52	31					0	0	0	0	G	70612767	G	G	70612767	3	3	86	1	0	0	0	0	1	0	0	0	15579	43	2	5	3112	5	TAF1	23	70612767	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	12678260	70612767	84657793	253	17352											
KIAA2022	340533	broad.mit.edu	37	chrX	73962848	73962848	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catcatcatcttcctctttgGaaccaactggcagccattcc	9	12	5	15	0	4	0	2	0	2	0	6	1	6	1	4	2	3	1	4	2	2	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:73962848G>T	uc004eby.2	-	3	2161	c.1544C>A	c.(1543-1545)TCC>TAC	p.S515Y		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	515					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTCCTCTTTGGAACCAACTGG	0.388													5	7					3.59834e-05	3.93923e-05	1	0	T	73962848	T	T	73962848	3	4	86	1	0	0	0	0	1	0	0	0	8308	1174	41	2	3014	2	KIAA2022	23	73962848	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	3350081	73962848	81307712	254	17353											
DACH2	117154	broad.mit.edu	37	chrX	85969652	85969652	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcagatgaaccatctcaatActattgccaacatggctgct	13	11	6	11	0	2	2	2	1	1	1	3	2	2	2	2	1	5	2	2	1	5	3			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:85969652A>G	uc004eew.2	+	6	1203	c.1033A>G	c.(1033-1035)ACT>GCT	p.T345A	DACH2_uc004eex.2_Missense_Mutation_p.T332A|DACH2_uc010nmq.2_Missense_Mutation_p.T211A|DACH2_uc011mra.1_Missense_Mutation_p.T178A|DACH2_uc010nmr.2_Missense_Mutation_p.T126A|DACH2_uc004eey.2_Missense_Mutation_p.T28A|DACH2_uc004eez.2_Missense_Mutation_p.T28A	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						CCATCTCAATACTATTGCCAA	0.448													18	21					0	0	0	0	G	85969652	G	G	85969652	3	3	86	1	0	0	0	0	1	0	0	0	4238	391	14	5	1055	5	DACH2	23	85969652	Missense_Mutation	SNP	A	TCGA-CN-6995-01A-31D-2012-08	12006804	85969652	69300908	255	17354											
NRK	203447	broad.mit.edu	37	chrX	105178437	105178437	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taactttgccagtgccatctGtgagtgtgttcaatgtaatc	9	15	9	8	0	2	1	1	1	1	0	3	1	2	1	2	0	3	2	2	0	3	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:105178437G>T	uc004emd.2	+	20	3802	c.3499_splice	c.e20+1	p.L1167_splice	NRK_uc010npc.1_Splice_Site_p.L835_splice	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase								ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						AGTGCCATCTGTGAGTGTGTT	0.368										HNSCC(51;0.14)			29	20					2.85442e-18	3.80589e-18	1	0	T	105178437	T	T	105178437	5	4	86	1	0	0	0	0	0	0	1	0	10709	1391	48	4	3578	4	NRK	23	105178437	Splice_Site	SNP	G	TCGA-CN-6995-01A-31D-2012-08	19208785	105178437	50092123	256	17355											
GLUD2	2747	broad.mit.edu	37	chrX	120181945	120181945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaggtcatcgaaggctaccGggcccagcacagccagcacc	10	3	13	15	2	1	0	1	0	0	0	2	2	1	1	4	4	4	3	4	4	2	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:120181945G>A	uc004eto.2	+	1	484	c.407G>A	c.(406-408)CGG>CAG	p.R136Q		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	136					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	GAAGGCTACCGGGCCCAGCAC	0.592													26	10					0	0	0	0	A	120181945	A	A	120181945	3	1	86	1	0	0	0	0	1	0	0	0	6514	1116	39	1	409	1	GLUD2	23	120181945	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	15003508	120181945	35088615	257	17356											
IDS	3423	broad.mit.edu	37	chrX	148585743	148585743	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgccagttggtcaatatttgGggacctcaccagcttatccc	8	12	9	12	0	2	0	2	0	0	0	3	1	3	1	4	3	2	2	4	3	3	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:148585743G>C	uc011mxe.1	-	2	382	c.184C>G	c.(184-186)CCA>GCA	p.P62A	IDS_uc011mxf.1_5'UTR|IDS_uc011mxg.1_5'UTR|IDS_uc010nsu.1_Intron|IDS_uc004fcw.3_Intron|IDS_uc011mxh.1_Missense_Mutation_p.P62A|IDS_uc011mxi.1_RNA|IDS_uc011mxj.1_Missense_Mutation_p.P62A	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	62						lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					TCAATATTTGGGGACCTCACC	0.562													4	9					0	0	0	0	C	148585743	C	C	148585743	3	2	86	1	0	0	0	0	1	0	0	0	7542	1232	43	4	1530	4	IDS	23	148585743	Missense_Mutation	SNP	G	TCGA-CN-6995-01A-31D-2012-08	28403798	148585743	6684817	258	17357											
GABRQ	55879	broad.mit.edu	37	chrX	151806746	151806746	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aactaccccagtcccatcccGaaattccacttcgagttctc	10	10	4	17	2	1	0	0	0	1	0	6	2	4	0	5	0	2	1	5	0	3	4			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:151806746G>A	uc004ffp.1	+	1	110	c.90G>A	c.(88-90)CCG>CCA	p.P30P		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	30	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GTCCCATCCCGAAATTCCACT	0.642													14	18					0	0	0	0	A	151806746	A	A	151806746	2	1	86	1	0	0	0	0	0	0	0	1	6209	1045	37	1		1	GABRQ	23	151806746	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	3221003	151806746	3463814	259	17358											
PNMA3	29944	broad.mit.edu	37	chrX	152226119	152226119	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggagtgcctggctgcctTgcagcaggtgttcggacctg	5	9	17	10	1	0	0	0	0	0	0	1	3	0	3	3	5	4	4	3	5	0	2			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:152226119T>A	uc004fhc.2	+	2	1043	c.707T>A	c.(706-708)TTG>TAG	p.L236*	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	236					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ctggctgccttgcagcaggtg	0													52	48					0	0	0	0	A	152226119	A	A	152226119	4	1	86	1	0	0	0	0	0	1	0	0	12210	1821	63	5	709	5	PNMA3	23	152226119	Nonsense_Mutation	SNP	T	TCGA-CN-6995-01A-31D-2012-08	419373	152226119	3044441	260	17359											
IL9R	3581	broad.mit.edu	37	chrX	155233507	155233507	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtggacccggagtacctGccccggagacacggtgagca	8	5	15	13	3	0	2	0	1	0	1	0	5	0	4	4	5	3	2	4	5	1	1			TCGA-CN-6995-01A-31D-2012-08	TCGA-CN-6995-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c0b6813d-4b3e-479e-81a7-1e5c2de89b0d	a4fef570-a560-4482-b7da-8bbe800c4b03	g.chrX:155233507G>T	uc004fnv.1	+	4	599	c.420G>T	c.(418-420)CTG>CTT	p.L140L	IL9R_uc010nvn.2_Silent_p.L119L|IL9R_uc004fnu.1_Missense_Mutation_p.C185F	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	140	Extracellular (Potential).				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGGAGTACCTGCCCCGGAGAC	0.622													13	24					1.05317e-09	1.28858e-09	1	0	T	155233507	T	T	155233507	2	4	86	1	0	0	0	0	0	0	0	1	7747	1306	46	4		4	IL9R	23	155233507	Silent	SNP	G	TCGA-CN-6995-01A-31D-2012-08	3007388	155233507	37053	261	17360											
C1orf187	374946	broad.mit.edu	37	chr1	11766403	11766403	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcctggcaggcgcccttgcaCctgggacccctgcccggaac	5	5	13	18	2	0	0	0	0	0	0	0	2	0	2	6	4	3	2	6	4	1	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr1:11766403C>T	uc001asr.1	+	2	228	c.88C>T	c.(88-90)CCT>TCT	p.P30S		NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor	30					axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		CGCCCTTGCACCTGGGACCCC	0.706													6	19					0	0	0	0	T	11766403	T	T	11766403	3	4	87	1	0	0	0	0	1	0	0	0	2030	507	18	4	90	4	C1orf187	1	11766403	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08		11766403	237484218	1	17361											
AHDC1	27245	broad.mit.edu	37	chr1	27874932	27874932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccttcttccgccgtccacggCccggcttggagctactctga	4	10	10	17	4	2	1	0	1	2	0	4	2	4	2	5	3	2	2	5	3	1	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr1:27874932C>T	uc009vsy.2	-	6	4664	c.3695G>A	c.(3694-3696)GGC>GAC	p.G1232D	AHDC1_uc009vsz.1_Missense_Mutation_p.G1232D	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1232							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CCGTCCACGGCCCGGCTTGGA	0.607													8	25					0	0	0	0	T	27874932	T	T	27874932	3	4	87	1	0	0	0	0	1	0	0	0	412	739	26	4	1120	4	AHDC1	1	27874932	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	16108529	27874932	221375689	2	17362											
FUBP1	8880	broad.mit.edu	37	chr1	78433858	78433858	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaatacttacagtcattttGaggagcaactttcttagcat	12	14	8	7	0	2	1	1	1	1	0	2	3	2	3	0	2	5	2	0	2	5	6			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr1:78433858G>A	uc001dii.2	-	3	330	c.241C>T	c.(241-243)CAA>TAA	p.Q81*	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Nonsense_Mutation_p.Q102*	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	81					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						CAGTCATTTTGAGGAGCAACT	0.313													6	28					0	0	0	0	A	78433858	A	A	78433858	4	1	87	1	0	0	0	0	0	1	0	0	6126	1299	45	2	1765	2	FUBP1	1	78433858	Nonsense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08	50558926	78433858	170816763	3	17363											
PTGS2	5743	broad.mit.edu	37	chr1	186648488	186648488	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctccatagaatcctgtccgGgtacaatcgcacttatactg	10	12	7	12	2	1	1	0	0	1	1	5	1	3	1	3	1	2	2	3	1	6	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr1:186648488G>A	uc001gsb.2	-	2	272	c.135C>T	c.(133-135)ACC>ACT	p.T45T	PTGS2_uc009wyo.2_5'UTR	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	45	EGF-like.				cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	ATCCTGTCCGGGTACAATCGC	0.443													19	30					0	0	0	0	A	186648488	A	A	186648488	2	1	87	1	0	0	0	0	0	0	0	1	12819	1219	43	4		4	PTGS2	1	186648488	Silent	SNP	G	TCGA-CN-6996-01A-11D-1912-08	108214630	186648488	62602133	4	17364											
RBM34	23029	broad.mit.edu	37	chr1	235324259	235324259	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggggctccagagaactgaaGagggacgccagccgaccggt	10	4	16	11	3	0	3	0	1	0	2	1	6	1	4	4	4	2	1	4	4	2	0			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr1:235324259G>C	uc001hwn.2	-	2	207	c.177C>G	c.(175-177)CTC>CTG	p.L59L	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Silent_p.L59L	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	59						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			GAGAACTGAAGAGGGACGCCA	0.567													9	45					0	0	0	0	C	235324259	C	C	235324259	2	2	87	1	0	0	0	0	0	0	0	1	13196	929	33	2		2	RBM34	1	235324259	Silent	SNP	G	TCGA-CN-6996-01A-11D-1912-08	48675771	235324259	13926362	5	17365											
KCNF1	3754	broad.mit.edu	37	chr2	11053827	11053827	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggagaccgcggccaagcaCgagctggagctgatggaact	10	5	15	11	3	0	2	0	1	0	1	0	6	0	4	2	4	4	3	2	4	2	0			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:11053827C>T	uc002rax.2	+	1	1765	c.1275C>T	c.(1273-1275)CAC>CAT	p.H425H		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	425	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CGGCCAAGCACGAGCTGGAGC	0.632													6	28					0	0	0	0	T	11053827	T	T	11053827	2	4	87	1	0	0	0	0	0	0	0	1	8065	535	19	1		1	KCNF1	2	11053827	Silent	SNP	C	TCGA-CN-6996-01A-11D-1912-08		11053827	232145546	6	17366											
FNDC4	64838	broad.mit.edu	37	chr2	27715571	27715571	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccttccctgaggactctgttCcggcccctttcccttctcct	2	14	6	19	1	2	1	0	1	2	0	6	2	5	2	7	2	0	1	7	2	0	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:27715571C>A	uc002rkx.2	-	6	1037	c.631G>T	c.(631-633)GAA>TAA	p.E211*	IFT172_uc002rku.2_5'Flank|IFT172_uc002rkw.2_5'Flank|IFT172_uc010yls.1_5'Flank|IFT172_uc010ezc.2_5'Flank|IFT172_uc002rkv.2_5'Flank|IFT172_uc010ylt.1_5'Flank	NM_022823	NP_073734	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	211	Cytoplasmic (Potential).					integral to membrane					0	Acute lymphoblastic leukemia(172;0.155)					GGACTCTGTTCCGGCCCCTTT	0.552													21	61					1.55795e-14	2.01734e-14	1	0	A	27715571	A	A	27715571	4	1	87	1	0	0	0	0	0	1	0	0	6003	864	30	2	81	2	FNDC4	2	27715571	Nonsense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	16661744	27715571	215483802	7	17367											
RTKN	6242	broad.mit.edu	37	chr2	74653510	74653510	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacagcatccagggaaaaggTtcggggtctcccccagggca	10	5	14	12	1	1	0	0	0	1	0	4	2	2	1	3	5	1	3	3	5	2	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:74653510T>C	uc002sle.2	-	12	1669	c.1552A>G	c.(1552-1554)ACC>GCC	p.T518A	RTKN_uc002slc.2_Missense_Mutation_p.T505A|RTKN_uc002sld.2_Missense_Mutation_p.T468A	NM_001015055	NP_001015055	Q9BST9	RTKN_HUMAN	rhotekin isoform a	518	Pro-rich.				apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1						AGGGAAAAGGTTCGGGGTCTC	0.677													23	80					0	0	0	0	C	74653510	C	C	74653510	3	2	87	1	0	0	0	0	1	0	0	0	13787	1725	60	5	143	5	RTKN	2	74653510	Missense_Mutation	SNP	T	TCGA-CN-6996-01A-11D-1912-08	46937939	74653510	168545863	8	17368											
RTKN	6242	broad.mit.edu	37	chr2	74654585	74654585	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agctgccacagagcctccatCcagctctgcagtgcttcccg	7	8	9	17	1	1	1	0	0	1	1	4	1	4	1	5	0	6	4	5	0	0	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:74654585C>T	uc002sle.2	-	10	1338	c.1221G>A	c.(1219-1221)TGG>TGA	p.W407*	RTKN_uc002slc.2_Nonsense_Mutation_p.W394*|RTKN_uc002sld.2_Nonsense_Mutation_p.W357*	NM_001015055	NP_001015055	Q9BST9	RTKN_HUMAN	rhotekin isoform a	407	PH.				apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1						GAGCCTCCATCCAGCTCTGCA	0.502													60	198					0	0	0	0	T	74654585	T	T	74654585	4	4	87	1	0	0	0	0	0	1	0	0	13787	856	30	2	482	2	RTKN	2	74654585	Nonsense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	1075	74654585	168544788	9	17369											
TMEM87B	84910	broad.mit.edu	37	chr2	112821764	112821764	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattccattgttctgggccTgtgaagtttaccatagtgtg	7	16	10	8	0	2	1	1	1	1	0	3	1	3	1	3	1	1	2	3	1	3	6			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:112821764T>C	uc002thm.2	+	3	621	c.252T>C	c.(250-252)CCT>CCC	p.P84P	TMEM87B_uc010fkg.2_Silent_p.P84P|TMEM87B_uc010fkh.2_Silent_p.P84P	NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	84						integral to membrane					0						GTTCTGGGCCTGTGAAGTTTA	0.308													3	144					0	0	0	0	C	112821764	C	C	112821764	2	2	87	1	0	0	0	0	0	0	0	1	16277	1567	55	5		5	TMEM87B	2	112821764	Silent	SNP	T	TCGA-CN-6996-01A-11D-1912-08	38167179	112821764	130377609	10	17370											
LRP1B	53353	broad.mit.edu	37	chr2	141474362	141474362	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattttattgaagcccatgtCtgtccagtagatggtatcat	11	15	8	7	0	2	2	1	1	1	1	3	2	3	2	2	1	1	2	2	1	5	5			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:141474362C>G	uc002tvj.1	-	36	6754	c.5782G>C	c.(5782-5784)GAC>CAC	p.D1928H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1928	Extracellular (Potential).|LDL-receptor class B 19.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAGCCCATGTCTGTCCAGTAG	0.363										TSP Lung(27;0.18)			3	77					0	0	0	0	G	141474362	G	G	141474362	3	3	87	1	0	0	0	0	1	0	0	0	9005	913	32	2	8241	2	LRP1B	2	141474362	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	28652598	141474362	101725011	11	17371											
GALNT5	11227	broad.mit.edu	37	chr2	158140861	158140861	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgtgctttgtggatgaaGtgtggtccactctcctgaga	7	14	12	8	0	2	2	1	2	1	1	4	4	3	3	2	2	1	1	2	2	1	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:158140861G>C	uc002tzg.2	+	2	1777	c.1522G>C	c.(1522-1524)GTG>CTG	p.V508L	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	508	Catalytic subdomain A.|Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						TGTGGATGAAGTGTGGTCCAC	0.488													21	59					0	0	0	0	C	158140861	C	C	158140861	3	2	87	1	0	0	0	0	1	0	0	0	6251	1029	36	4	1528	4	GALNT5	2	158140861	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08	16666499	158140861	85058512	12	17372											
SCN3A	6328	broad.mit.edu	37	chr2	165987855	165987855	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaaagatattccagccttCttggaaatagtaataaggat	16	12	7	6	0	2	1	1	0	1	1	3	3	3	3	2	2	1	1	2	2	6	7			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:165987855C>G	uc002ucx.2	-	16	2956	c.2464G>C	c.(2464-2466)GAA>CAA	p.E822Q	SCN3A_uc002ucy.2_Missense_Mutation_p.E773Q|SCN3A_uc002ucz.2_Missense_Mutation_p.E773Q|SCN3A_uc002uda.1_Missense_Mutation_p.E642Q|SCN3A_uc002udb.1_Missense_Mutation_p.E642Q	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	822						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTCCAGCCTTCTTGGAAATAG	0.393													13	76					0	0	0	0	G	165987855	G	G	165987855	3	3	87	1	0	0	0	0	1	0	0	0	13983	922	32	2	3590	2	SCN3A	2	165987855	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	7846994	165987855	77211518	13	17373											
BMPR2	659	broad.mit.edu	37	chr2	203332371	203332371	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacagatttatgtaatgtcaActttactgagaattttccac	13	15	5	8	0	1	2	1	1	0	2	2	3	2	2	1	0	2	1	1	0	5	7			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:203332371A>G	uc002uzf.3	+	3	1525	c.377A>G	c.(376-378)AAC>AGC	p.N126S	BMPR2_uc010ftr.2_Missense_Mutation_p.N126S|BMPR2_uc002uze.2_Missense_Mutation_p.N126S	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	126	Extracellular (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						TGTAATGTCAACTTTACTGAG	0.368													14	32					0	0	0	0	G	203332371	G	G	203332371	3	3	87	1	0	0	0	0	1	0	0	0	1474	43	2	5	387	5	BMPR2	2	203332371	Missense_Mutation	SNP	A	TCGA-CN-6996-01A-11D-1912-08	37344516	203332371	39867002	14	17374											
EPHA4	2043	broad.mit.edu	37	chr2	222321461	222321461	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgttcctggcagctgtcCgaactatacgatagcttcgc	7	12	10	12	3	0	0	0	0	0	0	3	2	2	0	2	1	4	4	2	1	4	5			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr2:222321461C>T	uc002vmq.2	-	7	1517	c.1475G>A	c.(1474-1476)CGG>CAG	p.R492Q	EPHA4_uc002vmr.2_Missense_Mutation_p.R492Q|EPHA4_uc010zlm.1_Missense_Mutation_p.R433Q|EPHA4_uc010zln.1_Missense_Mutation_p.R492Q	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	492	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GGCAGCTGTCCGAACTATACG	0.468													14	65					0	0	0	0	T	222321461	T	T	222321461	3	4	87	1	0	0	0	0	1	0	0	0	5193	652	23	1	1529	1	EPHA4	2	222321461	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	18989090	222321461	20877912	15	17375											
HGD	3081	broad.mit.edu	37	chr3	120394679	120394679	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggcagcgaggatcctctGaagaacactcattcccaaat	12	8	9	12	1	2	2	1	1	1	1	4	4	4	3	2	2	2	1	2	2	3	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr3:120394679G>A	uc003edw.2	-	2	417	c.47C>T	c.(46-48)TCA>TTA	p.S16L		NM_000187	NP_000178	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	16					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding				0				GBM - Glioblastoma multiforme(114;0.158)		AGGATCCTCTGAAGAACACTC	0.438													23	76					0	0	0	0	A	120394679	A	A	120394679	3	1	87	1	0	0	0	0	1	0	0	0	7123	1294	45	2	1342	2	HGD	3	120394679	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08		120394679	77627751	16	17376											
PIK3CB	5291	broad.mit.edu	37	chr3	138383967	138383967	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctactgttcagctgaatgtcAgcaattgtttcagaggtgct	9	14	10	8	0	3	2	3	1	0	1	3	2	3	2	0	1	4	5	0	1	3	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr3:138383967A>C	uc011bmq.1	-	18	2583	c.2583T>G	c.(2581-2583)GCT>GCG	p.A861A	PIK3CB_uc011bmn.1_Silent_p.A373A|PIK3CB_uc011bmo.1_Silent_p.A312A|PIK3CB_uc011bmp.1_Silent_p.A448A	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	861	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GCTGAATGTCAGCAATTGTTT	0.448													10	35					0	0	0	0	C	138383967	C	C	138383967	2	2	87	1	0	0	0	0	0	0	0	1	11969	175	7	5		5	PIK3CB	3	138383967	Silent	SNP	A	TCGA-CN-6996-01A-11D-1912-08	17989288	138383967	59638463	17	17377											
FXR1	8087	broad.mit.edu	37	chr3	180693130	180693130	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagattatatttctagagctGagtctcagagcagacaaaga	15	10	9	7	0	2	6	1	1	2	5	3	6	2	6	0	0	2	2	0	0	4	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr3:180693130G>A	uc003fkq.2	+	16	1655	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K	FXR1_uc003fkp.2_Missense_Mutation_p.E460K|FXR1_uc003fkr.2_Intron|FXR1_uc011bqj.1_Intron|FXR1_uc003fks.2_Missense_Mutation_p.E488K|FXR1_uc011bqk.1_Intron|FXR1_uc011bql.1_Missense_Mutation_p.E532K	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	545					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			TTCTAGAGCTGAGTCTCAGAG	0.308													3	10					0	0	0	0	A	180693130	A	A	180693130	3	1	87	1	0	0	0	0	1	0	0	0	6149	1291	45	2	1695	2	FXR1	3	180693130	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08	42309163	180693130	17329300	18	17378											
AFAP1	60312	broad.mit.edu	37	chr4	7774605	7774605	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccagggtgactccgcccGccagcgctttcttcaggctc	4	8	11	18	3	2	1	1	1	1	0	4	1	3	1	5	2	1	2	5	2	0	2			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr4:7774605G>A	uc003gkg.1	-	15	2216	c.1943C>T	c.(1942-1944)GCG>GTG	p.A648V	AFAP1_uc011bwk.1_Missense_Mutation_p.A732V|LOC84740_uc003gkd.3_RNA	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	648	Potential.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						GACTCCGCCCGCCAGCGCTTT	0.657													4	35					0	0	0	0	A	7774605	A	A	7774605	3	1	87	1	0	0	0	0	1	0	0	0	353	1087	38	1	261	1	AFAP1	4	7774605	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08		7774605	183379671	19	17379											
KDR	3791	broad.mit.edu	37	chr4	55964338	55964338	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctctggggaattcccatttGctggcatcataaggcagtcg	8	12	11	10	1	2	0	1	0	1	0	5	1	3	1	1	4	1	3	1	4	2	3			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr4:55964338G>T	uc003has.2	-	17	2777	c.2475C>A	c.(2473-2475)AGC>AGA	p.S825R	KDR_uc003hat.1_Missense_Mutation_p.S825R	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	825	Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ATTCCCATTTGCTGGCATCAT	0.453			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			14	60					6.31663e-08	7.87629e-08	1	0	T	55964338	T	T	55964338	3	4	87	1	0	0	0	0	1	0	0	0	8178	1310	46	4	1651	4	KDR	4	55964338	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08	48189733	55964338	135189938	20	17380											
LIN54	132660	broad.mit.edu	37	chr4	83849335	83849335	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaacatcgtccgaattcctCaagtatcatccgttccgctg	10	11	6	14	4	2	0	2	0	0	0	7	1	6	0	4	0	1	3	4	0	4	3			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr4:83849335C>G	uc003hnx.3	-	13	2548	c.2170G>C	c.(2170-2172)GAG>CAG	p.E724Q	LIN54_uc003hnz.3_Missense_Mutation_p.E503Q|LIN54_uc003hny.3_Missense_Mutation_p.E323Q|LIN54_uc010ijt.2_Missense_Mutation_p.E635Q|LIN54_uc010iju.2_Missense_Mutation_p.E323Q|LIN54_uc010ijv.2_Missense_Mutation_p.E503Q	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	724					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				CCGAATTCCTCAAGTATCATC	0.468													4	76					0	0	0	0	G	83849335	G	G	83849335	3	3	87	1	0	0	0	0	1	0	0	0	8851	835	29	2	83	2	LIN54	4	83849335	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	27884997	83849335	107304941	21	17381											
EGF	1950	broad.mit.edu	37	chr4	110866357	110866357	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aattaacctccattcatcatTtgtaccacttggtgaactga	12	14	5	10	0	2	2	2	2	0	0	3	2	3	2	3	1	3	1	3	1	4	5	rs139711858		TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr4:110866357T>A	uc003hzy.3	+	5	1318	c.866T>A	c.(865-867)TTT>TAT	p.F289Y	EGF_uc011cfu.1_Missense_Mutation_p.F289Y|EGF_uc011cfv.1_Missense_Mutation_p.F289Y	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	289	Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CATTCATCATTTGTACCACTT	0.448													9	28					0	0	0	0	A	110866357	A	A	110866357	3	1	87	1	0	0	0	0	1	0	0	0	4984	1841	64	5	884	5	EGF	4	110866357	Missense_Mutation	SNP	T	TCGA-CN-6996-01A-11D-1912-08	27017022	110866357	80287919	22	17382											
C4orf21	55345	broad.mit.edu	37	chr4	113533743	113533743	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgtaataaatggtttcctCactgtaatggagaaaagaaa	17	11	8	5	0	1	2	1	0	0	2	2	3	2	2	1	2	0	3	1	2	7	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr4:113533743C>G	uc003iau.2	-	7	2815	c.2604G>C	c.(2602-2604)GTG>GTC	p.V868V	C4orf21_uc003iaw.2_Silent_p.V868V	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		ATGGTTTCCTCACTGTAATGG	0.284													5	27					0	0	0	0	G	113533743	G	G	113533743	2	3	87	1	0	0	0	0	0	0	0	1	2264	840	29	2		2	C4orf21	4	113533743	Silent	SNP	C	TCGA-CN-6996-01A-11D-1912-08	2667386	113533743	77620533	23	17383											
RGMB	285704	broad.mit.edu	37	chr5	98115428	98115428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctatgctggctgcacccagcGaacttcaaaagcctgccgtg	9	8	10	14	2	1	0	1	0	0	0	1	1	1	0	3	1	6	3	3	1	4	2			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr5:98115428G>A	uc003knc.2	+	4	806	c.404G>A	c.(403-405)CGA>CAA	p.R135Q	RGMB_uc003knb.2_Missense_Mutation_p.R135Q	NM_001012761	NP_001012779	Q6NW40	RGMB_HUMAN	RGM domain family, member B	94					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding				0		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		TGCACCCAGCGAACTTCAAAA	0.542													11	89					0	0	0	0	A	98115428	A	A	98115428	3	1	87	1	0	0	0	0	1	0	0	0	13346	1058	37	1	414	1	RGMB	5	98115428	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08		98115428	82799832	24	17384											
HSD17B4	3295	broad.mit.edu	37	chr5	118872146	118872146	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgaaaagtggttctggaaaAgtgtaccaaggccctgcaaa	14	8	11	8	0	1	1	0	1	1	0	1	2	1	2	2	3	2	3	2	3	7	2			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr5:118872146A>C	uc003ksj.2	+	23	2145	c.2022A>C	c.(2020-2022)AAA>AAC	p.K674N	HSD17B4_uc011cwg.1_Missense_Mutation_p.K650N|HSD17B4_uc011cwh.1_Missense_Mutation_p.K656N|HSD17B4_uc011cwi.1_Missense_Mutation_p.K699N|HSD17B4_uc003ksk.3_Missense_Mutation_p.K527N|HSD17B4_uc011cwj.1_Missense_Mutation_p.K527N|HSD17B4_uc010jcn.1_Missense_Mutation_p.K412N|HSD17B4_uc010jco.1_Intron	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	674	SCP2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	GTTCTGGAAAAGTGTACCAAG	0.418													11	43					0	0	0	0	C	118872146	C	C	118872146	3	2	87	1	0	0	0	0	1	0	0	0	7425	69	3	5	2112	5	HSD17B4	5	118872146	Missense_Mutation	SNP	A	TCGA-CN-6996-01A-11D-1912-08	20756718	118872146	62043114	25	17385											
ZNF300	91975	broad.mit.edu	37	chr5	150275429	150275429	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtttttccccagtatgaaCtaactgatgtgtaatgagtt	11	15	9	6	0	0	3	0	3	0	0	1	3	1	3	2	1	2	4	2	1	4	6			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr5:150275429C>A	uc003lsy.1	-	6	1639	c.1372G>T	c.(1372-1374)GTT>TTT	p.V458F	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	458	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAGTATGAACTAACTGATGT	0.398													9	44					0.000274275	0.000333756	1	0	A	150275429	A	A	150275429	3	1	87	1	0	0	0	0	1	0	0	0	17898	565	20	4	446	4	ZNF300	5	150275429	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	31403283	150275429	30639831	26	17386											
CD2AP	23607	broad.mit.edu	37	chr6	47501441	47501441	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgaataagcacctatggacTtccagctggaggaattcagc	13	8	10	10	1	1	0	1	0	0	0	2	4	2	3	2	3	3	2	2	3	4	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr6:47501441T>G	uc003oyw.2	+	3	725	c.269T>G	c.(268-270)CTT>CGT	p.L90R		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	90	Interaction with ANLN and localization to the midbody.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			ACCTATGGACTTCCAGCTGGA	0.383													7	20					0	0	0	0	G	47501441	G	G	47501441	3	3	87	1	0	0	0	0	1	0	0	0	3009	1609	56	5	279	5	CD2AP	6	47501441	Missense_Mutation	SNP	T	TCGA-CN-6996-01A-11D-1912-08		47501441	123613626	27	17387											
C6orf204	387119	broad.mit.edu	37	chr6	118887049	118887049	+	Frame_Shift_Del	DEL	T	-	-																															cagtccagagttgatgaccgTtttttatttatttccttgtc																										TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr6:118887049delT	uc003pxz.1	-	3	1251	c.663delA	c.(661-663)AAAfs	p.K221fs	C6orf204_uc003pya.1_Frame_Shift_Del_p.K224fs|C6orf204_uc003pyb.2_Frame_Shift_Del_p.K221fs|C6orf204_uc011ebj.1_Frame_Shift_Del_p.K119fs|C6orf204_uc003pyc.2_Frame_Shift_Del_p.K224fs|C6orf204_uc011ebl.1_Frame_Shift_Del_p.K119fs	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	221						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		TTGATGACCGTTTTTTATTTA	0.418													---	---	---								-	118887049	-	-	118887049	7	5	87	1	0	1	0	1	0	0	0	0	2363	1722	60	0	1852	0	C6orf204	6	118887049	Frame_Shift_Del	DEL	T	TCGA-CN-6996-01A-11D-1912-08	71385608	118887049	52228018	28	17388											
BMPER	168667	broad.mit.edu	37	chr7	34118794	34118794	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcttgaaagtgaccaccaaAgcaggtggggcgtctgtggc	9	8	14	10	1	2	2	0	2	2	0	2	2	2	2	2	4	1	1	2	4	2	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr7:34118794A>G	uc011kap.1	+	12	1518	c.1404A>G	c.(1402-1404)AAA>AAG	p.K468K		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	468	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						TGACCACCAAAGCAGGTGGGG	0.622													12	59					0	0	0	0	G	34118794	G	G	34118794	2	3	87	1	0	0	0	0	0	0	0	1	1471	69	3	5		5	BMPER	7	34118794	Silent	SNP	A	TCGA-CN-6996-01A-11D-1912-08		34118794	125019869	29	17389											
LIMK1	3984	broad.mit.edu	37	chr7	73523259	73523259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtcatgcgatgcctggaaCaccccaacgtgctcaagttc	10	8	10	13	2	2	0	2	0	0	0	3	2	2	1	3	2	5	2	3	2	3	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr7:73523259C>T	uc003uaa.1	+	10	1342	c.1177C>T	c.(1177-1179)CAC>TAC	p.H393Y	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.H359Y|LIMK1_uc003uac.1_Missense_Mutation_p.H185Y	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	393	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				ATGCCTGGAACACCCCAACGT	0.562													18	36					0	0	0	0	T	73523259	T	T	73523259	3	4	87	1	0	0	0	0	1	0	0	0	8842	478	17	4	1215	4	LIMK1	7	73523259	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	39404465	73523259	85615404	30	17390											
CTTNBP2	83992	broad.mit.edu	37	chr7	117351760	117351760	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggaagaaaagatttaactCttgaaacacccaactcagtc	17	8	6	10	0	2	3	1	1	1	2	3	4	2	4	1	1	3	0	1	1	6	3			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr7:117351760C>G	uc003vjf.2	-	23	4915	c.4823G>C	c.(4822-4824)AGA>ACA	p.R1608T		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1608										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		AGATTTAACTCTTGAAACACC	0.423													3	71					0	0	0	0	G	117351760	G	G	117351760	3	3	87	1	0	0	0	0	1	0	0	0	4062	913	32	2	172	2	CTTNBP2	7	117351760	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	43828501	117351760	41786903	31	17391											
KIAA0146	23514	broad.mit.edu	37	chr8	48353089	48353089	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtccccaggacactgtccGgatcttccctccctggtgag	5	9	10	17	2	1	1	0	1	1	0	5	3	5	3	6	3	0	0	6	3	0	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr8:48353089G>A	uc003xqd.2	+	8	1091	c.1082G>A	c.(1081-1083)CGG>CAG	p.R361Q	KIAA0146_uc011lcz.1_RNA|KIAA0146_uc011lda.1_Missense_Mutation_p.R50Q|KIAA0146_uc011ldb.1_Missense_Mutation_p.R361Q|KIAA0146_uc010lxs.2_5'UTR|KIAA0146_uc011ldc.1_Missense_Mutation_p.R291Q|KIAA0146_uc011ldd.1_Missense_Mutation_p.R301Q|KIAA0146_uc003xqe.2_5'UTR|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.R50Q|KIAA0146_uc010lxt.2_Missense_Mutation_p.R50Q	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	361											0		Lung NSC(58;0.175)				GACACTGTCCGGATCTTCCCT	0.532													16	72					0	0	0	0	A	48353089	A	A	48353089	3	1	87	1	0	0	0	0	1	0	0	0	8196	1116	39	1	1112	1	KIAA0146	8	48353089	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08		48353089	98010933	32	17392											
EYA1	2138	broad.mit.edu	37	chr8	72267106	72267106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcactactaccactcagaCggctatgcgggctggttaga	10	10	10	11	2	2	2	2	0	0	2	2	2	2	2	1	3	3	3	1	3	4	5	rs74720958	by1000genomes	TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr8:72267106C>T	uc003xys.3	-	2	322	c.35G>A	c.(34-36)CGT>CAT	p.R12H	EYA1_uc003xyr.3_Missense_Mutation_p.R12H|EYA1_uc003xyt.3_Intron|EYA1_uc010lzf.2_5'UTR|EYA1_uc003xyu.2_Missense_Mutation_p.R12H|EYA1_uc011lfe.1_Missense_Mutation_p.R12H|EYA1_uc003xyv.2_5'UTR	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	12					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			ACCACTCAGACGGCTATGCGG	0.458													51	125					0	0	0	0	T	72267106	T	T	72267106	3	4	87	1	0	0	0	0	1	0	0	0	5353	536	19	1	1807	1	EYA1	8	72267106	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	23914017	72267106	74096916	33	17393											
RNF19A	25897	broad.mit.edu	37	chr8	101299799	101299799	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgtctaagcataaattcttCgtatttttccatcaagacat	12	15	4	10	2	3	1	1	0	2	1	5	1	4	1	2	0	1	2	2	0	5	7			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr8:101299799C>T	uc003yjj.1	-	3	921	c.604G>A	c.(604-606)GAA>AAA	p.E202K	RNF19A_uc003yjk.1_Missense_Mutation_p.E202K|RNF19A_uc003yjl.1_Missense_Mutation_p.E202K	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	202	IBR-type.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			ATAAATTCTTCGTATTTTTCC	0.388													7	96					0	0	0	0	T	101299799	T	T	101299799	3	4	87	1	0	0	0	0	1	0	0	0	13535	893	31	1	1948	1	RNF19A	8	101299799	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	29032693	101299799	45064223	34	17394											
CDKN2A	1029	broad.mit.edu	37	chr9	21971208	21971208	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctgcccatcatcatgacCtgccagagagaacagaatgg	12	6	11	12	1	2	4	2	1	0	3	2	5	2	4	3	1	3	1	3	1	2	0			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr9:21971208C>T	uc003zpk.2	-	2	363	c.151_splice	c.e2-1	p.V51_splice	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Splice_Site|CDKN2A_uc010miu.2_Splice_Site|CDKN2A_uc003zpl.2_Splice_Site_p.G106_splice	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1						cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(28)|p.V28_V51del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCATCATGACCTGCCAGAGAG	0.667		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	6					0	0	0	0	T	21971208	T	T	21971208	5	4	87	1	0	0	0	0	0	0	1	0	3176	695	24	4	328	4	CDKN2A	9	21971208	Splice_Site	SNP	C	TCGA-CN-6996-01A-11D-1912-08		21971208	119242223	35	17395											
SH2D3C	10044	broad.mit.edu	37	chr9	130507309	130507309	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagctggggctcactggaaCggcgggcgacaggggaggca	9	3	19	10	3	1	0	1	0	0	0	1	3	1	2	0	8	2	3	0	8	1	0			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr9:130507309C>T	uc004bsc.2	-	7	1476	c.1334G>A	c.(1333-1335)CGT>CAT	p.R445H	SH2D3C_uc010mxo.2_Missense_Mutation_p.R285H|SH2D3C_uc004bry.2_Missense_Mutation_p.R287H|SH2D3C_uc004brz.3_Missense_Mutation_p.R91H|SH2D3C_uc011mak.1_Missense_Mutation_p.R91H|SH2D3C_uc004bsa.2_Missense_Mutation_p.R288H|SH2D3C_uc004bsb.2_Missense_Mutation_p.R377H	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	445				R -> C (in Ref. 1; AAD28246 and 2; AAQ89948).	JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						CTCACTGGAACGGCGGGCGAC	0.657													65	49					0	0	0	0	T	130507309	T	T	130507309	3	4	87	1	0	0	0	0	1	0	0	0	14299	536	19	1	1272	1	SH2D3C	9	130507309	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	108536101	130507309	10706122	36	17396											
SETX	23064	broad.mit.edu	37	chr9	135203150	135203150	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagctgttgaagttggctCaggacactgacgaaatttct	10	12	10	9	1	3	2	2	2	1	0	3	4	3	3	0	2	1	4	0	2	2	3			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr9:135203150C>G	uc004cbk.2	-	10	4018	c.3835G>C	c.(3835-3837)GAG>CAG	p.E1279Q	SETX_uc004cbj.2_Missense_Mutation_p.E898Q|SETX_uc010mzt.2_Missense_Mutation_p.E898Q	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1279					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GAAGTTGGCTCAGGACACTGA	0.428													26	177					0	0	0	0	G	135203150	G	G	135203150	3	3	87	1	0	0	0	0	1	0	0	0	14206	835	29	2	4266	2	SETX	9	135203150	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	4695841	135203150	6010281	37	17397											
A1CF	29974	broad.mit.edu	37	chr10	52576013	52576013	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccactggttttgctagggtGacttcaatgggggaaccatc	8	12	12	9	0	1	1	1	1	0	0	3	2	2	2	2	4	2	2	2	4	3	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr10:52576013G>A	uc001jjj.2	-	9	1082	c.894C>T	c.(892-894)GTC>GTT	p.V298V	A1CF_uc010qhn.1_Silent_p.V306V|A1CF_uc001jji.2_Silent_p.V298V|A1CF_uc001jjh.2_Silent_p.V306V|A1CF_uc010qho.1_Silent_p.V306V|A1CF_uc009xov.2_Silent_p.V298V	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	298	RRM 3.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						TTGCTAGGGTGACTTCAATGG	0.478													16	40					0	0	0	0	A	52576013	A	A	52576013	2	1	87	1	0	0	0	0	0	0	0	1	2	1277	45	2		2	A1CF	10	52576013	Silent	SNP	G	TCGA-CN-6996-01A-11D-1912-08		52576013	82958734	38	17398											
SUPV3L1	6832	broad.mit.edu	37	chr10	70960106	70960106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaagggagagagagaactaGaaccaatcacaacctctcaa	20	4	8	9	0	2	3	2	0	1	3	3	6	2	4	2	1	3	0	2	1	8	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr10:70960106G>A	uc001jpe.1	+	11	1424	c.1369G>A	c.(1369-1371)GAA>AAA	p.E457K	SUPV3L1_uc010qjd.1_Missense_Mutation_p.E326K	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	457	Helicase C-terminal.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						GAGAGAACTAGAACCAATCAC	0.413													22	73					0	0	0	0	A	70960106	A	A	70960106	3	1	87	1	0	0	0	0	1	0	0	0	15468	943	33	2	1411	2	SUPV3L1	10	70960106	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08	18384093	70960106	64574641	39	17399											
TEAD1	7003	broad.mit.edu	37	chr11	12901270	12901270	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaaggatcagactgcaaagGataaggccctgcagcacatg	14	6	11	10	0	2	1	2	0	0	1	2	3	2	3	1	3	3	3	1	3	3	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr11:12901270G>T	uc001mkj.3	+	6	966	c.301G>T	c.(301-303)GAT>TAT	p.D101Y	TEAD1_uc001mkk.3_Missense_Mutation_p.D20Y|TEAD1_uc009ygl.2_5'UTR	NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1	116					hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GACTGCAAAGGATAAGGCCCT	0.562													5	62					2.0095e-06	2.47511e-06	1	0	T	12901270	T	T	12901270	3	4	87	1	0	0	0	0	1	0	0	0	15804	1174	41	2	360	2	TEAD1	11	12901270	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08		12901270	122105246	40	17400											
AHNAK	79026	broad.mit.edu	37	chr11	62293150	62293150	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgggcaggttcacatccacTtcagggccctctgctttgaa	7	12	10	12	0	3	1	2	1	1	0	4	1	4	1	2	3	1	3	2	3	1	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr11:62293150T>C	uc001ntl.2	-	5	9039	c.8739A>G	c.(8737-8739)GAA>GAG	p.E2913E	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2913					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCACATCCACTTCAGGGCCCT	0.517													76	294					0	0	0	0	C	62293150	C	C	62293150	2	2	87	1	0	0	0	0	0	0	0	1	414	1606	56	5		5	AHNAK	11	62293150	Silent	SNP	T	TCGA-CN-6996-01A-11D-1912-08	49391880	62293150	72713366	41	17401											
C11orf82	220042	broad.mit.edu	37	chr11	82644784	82644784	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtattttattcagatcttGatggtaactatgaaaaaata	15	16	6	4	0	2	3	1	2	1	1	2	3	2	3	0	1	1	2	0	1	8	8			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr11:82644784G>C	uc001ozt.2	+	6	2648	c.2404G>C	c.(2404-2406)GAT>CAT	p.D802H	C11orf82_uc010rsr.1_Missense_Mutation_p.D501H|C11orf82_uc010rss.1_Missense_Mutation_p.D501H|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	802					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						TTCAGATCTTGATGGTAACTA	0.363													3	23					0	0	0	0	C	82644784	C	C	82644784	3	2	87	1	0	0	0	0	1	0	0	0	1671	1290	45	2	2418	2	C11orf82	11	82644784	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08	20351634	82644784	52361732	42	17402											
MLL2	8085	broad.mit.edu	37	chr12	49434776	49434776	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctccccctaccccagggctCtcaggcacagccaagttatc	8	7	7	19	0	1	0	1	0	1	0	4	0	2	0	6	2	2	3	6	2	3	2			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr12:49434776C>G	uc001rta.3	-	31	6777	c.6777G>C	c.(6775-6777)GAG>GAC	p.E2259D		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2259	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCCCAGGGCTCTCAGGCACAG	0.637			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			6	77					0	0	0	0	G	49434776	G	G	49434776	3	3	87	1	0	0	0	0	1	0	0	0	9674	912	32	2	9932	2	MLL2	12	49434776	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08		49434776	84417119	43	17403											
ACAD10	80724	broad.mit.edu	37	chr12	112150388	112150388	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttccaaacactcggcctgtGaaaaagacgatggaaattcc	14	8	9	10	2	0	2	0	1	0	1	3	4	2	3	3	2	1	1	3	2	4	2			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr12:112150388G>A	uc001tsq.2	+	6	977	c.777G>A	c.(775-777)GTG>GTA	p.V259V	ACAD10_uc001tso.3_Silent_p.V259V|ACAD10_uc001tsp.2_Silent_p.V259V|ACAD10_uc009zvx.2_Silent_p.V290V|ACAD10_uc001tsr.2_5'UTR|ACAD10_uc001tss.1_5'Flank	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	259							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						CTCGGCCTGTGAAAAAGACGA	0.438													26	206					0	0	0	0	A	112150388	A	A	112150388	2	1	87	1	0	0	0	0	0	0	0	1	108	1277	45	2		2	ACAD10	12	112150388	Silent	SNP	G	TCGA-CN-6996-01A-11D-1912-08	62715612	112150388	21701507	44	17404											
PCDH17	27253	broad.mit.edu	37	chr13	58299273	58299273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgcattccagagccagcCgggattccagtgagatgggt	9	9	14	9	1	0	2	0	1	0	2	2	4	2	3	4	2	3	1	4	2	0	2			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr13:58299273C>T	uc001vhq.1	+	4	4217	c.3325C>T	c.(3325-3327)CGG>TGG	p.R1109W	PCDH17_uc010aec.1_Missense_Mutation_p.R1108W|PCDH17_uc001vhr.1_Missense_Mutation_p.R198W	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1109	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CAGAGCCAGCCGGGATTCCAG	0.522													6	203					0	0	0	0	T	58299273	T	T	58299273	3	4	87	1	0	0	0	0	1	0	0	0	11566	643	23	1	3339	1	PCDH17	13	58299273	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08		58299273	56870605	45	17405											
DIAPH3	81624	broad.mit.edu	37	chr13	60545216	60545216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agaaggcagtggaggcggagGaggaagtgctgagtggccag	11	4	21	5	1	0	2	0	1	0	1	0	6	0	6	1	7	1	2	1	7	2	0			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr13:60545216G>A	uc001vht.2	-	16	1948	c.1729C>T	c.(1729-1731)CCT>TCT	p.P577S	DIAPH3_uc001vhu.2_Missense_Mutation_p.P314S|DIAPH3_uc001vhv.2_Missense_Mutation_p.P155S	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	577	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GGAGGCGGAGGAGGAAGTGCT	0.552													5	31					0	0	0	0	A	60545216	A	A	60545216	3	1	87	1	0	0	0	0	1	0	0	0	4542	1174	41	2	1924	2	DIAPH3	13	60545216	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08	2245943	60545216	54624662	46	17406											
LMO7	4008	broad.mit.edu	37	chr13	76419476	76419476	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttaggaataaatccagaTctactactgaactggatgat	14	13	8	6	0	1	3	0	2	1	1	2	5	2	5	1	2	3	1	1	2	7	5			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr13:76419476T>C	uc001vjv.2	+	23	4172	c.3412T>C	c.(3412-3414)TCT>CCT	p.S1138P	LMO7_uc010thv.1_Missense_Mutation_p.S1089P|LMO7_uc001vjt.1_Missense_Mutation_p.S1037P|LMO7_uc010thw.1_Missense_Mutation_p.S1015P|LMO7_uc001vjw.1_Missense_Mutation_p.S1044P	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1423						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TAAATCCAGATCTACTACTGA	0.313													6	16					0	0	0	0	C	76419476	C	C	76419476	3	2	87	1	0	0	0	0	1	0	0	0	8897	1435	50	5	4373	5	LMO7	13	76419476	Missense_Mutation	SNP	T	TCGA-CN-6996-01A-11D-1912-08	15874260	76419476	38750402	47	17407											
SLC7A7	9056	broad.mit.edu	37	chr14	23243214	23243214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaagtaaaagggcaggcCtgagagggcaatggcaatgc	14	4	17	6	0	0	1	0	1	0	1	0	4	0	2	1	5	1	4	1	5	5	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr14:23243214C>T	uc001wgr.3	-	9	1495	c.1357G>A	c.(1357-1359)GGC>AGC	p.G453S	SLC7A7_uc001wgs.3_Missense_Mutation_p.G453S|SLC7A7_uc001wgt.3_Missense_Mutation_p.G453S|SLC7A7_uc001wgu.3_Missense_Mutation_p.G453S|SLC7A7_uc001wgv.3_Missense_Mutation_p.G453S	NM_003982	NP_003973	Q9UM01	YLAT1_HUMAN	solute carrier family 7 member 7	453	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			ovary(1)|breast(1)	2	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		AAGGGCAGGCCTGAGAGGGCA	0.522													15	45					0	0	0	0	T	23243214	T	T	23243214	3	4	87	1	0	0	0	0	1	0	0	0	14767	681	24	4	186	4	SLC7A7	14	23243214	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08		23243214	84106326	48	17408											
C14orf37	145407	broad.mit.edu	37	chr14	58605875	58605875	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggatcttcagagaccaccaGttggggagtctgctttgagg	8	11	14	8	0	3	2	1	1	2	1	3	5	3	4	2	4	1	2	2	4	0	3			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr14:58605875G>A	uc001xdc.2	-	2	313	c.202C>T	c.(202-204)CTG>TTG	p.L68L	C14orf37_uc010tro.1_Silent_p.L106L|C14orf37_uc001xdd.2_Silent_p.L68L|C14orf37_uc001xde.2_Silent_p.L68L	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	68	Extracellular (Potential).					integral to membrane	binding				0						GAGACCACCAGTTGGGGAGTC	0.453													40	136					0	0	0	0	A	58605875	A	A	58605875	2	1	87	1	0	0	0	0	0	0	0	1	1777	1020	36	4		4	C14orf37	14	58605875	Silent	SNP	G	TCGA-CN-6996-01A-11D-1912-08	35362661	58605875	48743665	49	17409											
CLN6	54982	broad.mit.edu	37	chr15	68503628	68503628	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtgacccaggtactcatcaTaatagtagagcagctcaaag	15	8	9	9	0	3	2	3	1	0	1	3	2	3	2	1	1	3	4	1	1	5	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr15:68503628T>A	uc002arf.2	-	5	673	c.515A>T	c.(514-516)TAT>TTT	p.Y172F	CLN6_uc010ujy.1_Intron|CLN6_uc010ujz.1_Missense_Mutation_p.Y204F	NM_017882	NP_060352	Q9NWW5	CLN6_HUMAN	CLN6 protein	172					cell death|cholesterol metabolic process|ganglioside metabolic process|glycosaminoglycan metabolic process|lysosomal lumen acidification|positive regulation of proteolysis|protein catabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	protein homodimerization activity				0						GTACTCATCATAATAGTAGAG	0.602													24	65					0	0	0	0	A	68503628	A	A	68503628	3	1	87	1	0	0	0	0	1	0	0	0	3560	1406	49	5	432	5	CLN6	15	68503628	Missense_Mutation	SNP	T	TCGA-CN-6996-01A-11D-1912-08		68503628	34027764	50	17410											
SEMA7A	8482	broad.mit.edu	37	chr15	74709052	74709052	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtggctttgatgaactgtGggtctgccagggacagaggc	7	10	17	7	0	1	3	0	2	1	1	1	4	1	4	1	5	2	1	1	5	1	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr15:74709052G>C	uc002axv.2	-	7	705	c.665C>G	c.(664-666)CCA>CGA	p.P222R	SEMA7A_uc010ulk.1_Missense_Mutation_p.P57R|SEMA7A_uc010ull.1_Missense_Mutation_p.P208R	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	222	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						GATGAACTGTGGGTCTGCCAG	0.567													22	84					0	0	0	0	C	74709052	C	C	74709052	3	2	87	1	0	0	0	0	1	0	0	0	14108	1348	47	4	1367	4	SEMA7A	15	74709052	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08	6205424	74709052	27822340	51	17411											
NUBP1	4682	broad.mit.edu	37	chr16	10846524	10846524	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttcccaagataatgggattgGaaggagagcaggtaatagcc	14	8	13	6	0	0	2	0	0	0	2	1	5	1	4	2	4	2	2	2	4	5	5			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr16:10846524G>A	uc002daa.1	+	4	339	c.316G>A	c.(316-318)GAA>AAA	p.E106K	NUBP1_uc010bum.1_Missense_Mutation_p.G12E|NUBP1_uc002dab.1_Missense_Mutation_p.E106K	NM_002484	NP_002475	P53384	NUBP1_HUMAN	nucleotide binding protein 1	106					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			ovary(1)|skin(1)	2						AATGGGATTGGAAGGAGAGCA	0.438													22	118					0	0	0	0	A	10846524	A	A	10846524	3	1	87	1	0	0	0	0	1	0	0	0	10769	1175	41	2	330	2	NUBP1	16	10846524	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08		10846524	79508229	52	17412											
GTF3C1	2975	broad.mit.edu	37	chr16	27561047	27561047	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcatagaagctgatgccCgggtgcgtggcgagggcccg	6	7	16	12	4	1	2	1	1	0	1	2	3	2	2	3	3	3	1	3	3	2	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr16:27561047C>T	uc002dov.1	-	1	205	c.165G>A	c.(163-165)CCG>CCA	p.P55P	GTF3C1_uc002dou.2_Silent_p.P55P|KIAA0556_uc002dow.2_5'Flank	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	55						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						AGCTGATGCCCGGGTGCGTGG	0.632													4	28					0	0	0	0	T	27561047	T	T	27561047	2	4	87	1	0	0	0	0	0	0	0	1	6911	639	23	1		1	GTF3C1	16	27561047	Silent	SNP	C	TCGA-CN-6996-01A-11D-1912-08	16714523	27561047	62793706	53	17413											
TP53	7157	broad.mit.edu	37	chr17	7577568	7577568	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcccatgcaggaactgttaCacatgtagttgtagtggatg	10	11	12	8	1	0	0	0	0	0	0	0	2	0	2	1	2	3	5	1	2	4	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr17:7577568C>A	uc002gim.2	-	7	907	c.713G>T	c.(712-714)TGT>TTT	p.C238F	TP53_uc002gig.1_Missense_Mutation_p.C238F|TP53_uc002gih.2_Missense_Mutation_p.C238F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106F|TP53_uc010cng.1_Missense_Mutation_p.C106F|TP53_uc002gii.1_Missense_Mutation_p.C106F|TP53_uc010cnh.1_Missense_Mutation_p.C238F|TP53_uc010cni.1_Missense_Mutation_p.C238F|TP53_uc002gij.2_Missense_Mutation_p.C238F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145F|TP53_uc002gio.2_Missense_Mutation_p.C106F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(34)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C238del(1)|p.C238G(1)|p.C238C(1)|p.M237fs*1(1)|p.C145F(1)|p.H233fs*6(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.M237_C238insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			30	48					5.60225e-13	7.16237e-13	1	0	A	7577568	A	A	7577568	3	1	87	1	0	0	0	0	1	0	0	0	16448	478	17	4	577	4	TP53	17	7577568	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08		7577568	73617642	54	17414											
MUC16	94025	broad.mit.edu	37	chr19	9090831	9090831	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgcttagtgtcatggaaaaAgggatagctgagttgggcat	11	12	14	4	0	1	1	1	1	0	0	1	3	1	3	0	3	2	4	0	3	4	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr19:9090831A>G	uc002mkp.2	-	1	1188	c.984T>C	c.(982-984)CCT>CCC	p.P328P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	328	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCATGGAAAAAGGGATAGCTG	0.522													3	76					0	0	0	0	G	9090831	G	G	9090831	2	3	87	1	0	0	0	0	0	0	0	1	10026	59	3	5		5	MUC16	19	9090831	Silent	SNP	A	TCGA-CN-6996-01A-11D-1912-08		9090831	50038152	55	17415											
GIPC1	10755	broad.mit.edu	37	chr19	14591280	14591280	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtggatgtggtcgatcacGctgccctccttgatgcgctg	5	11	14	11	3	1	1	1	1	0	0	3	3	2	2	2	3	2	2	2	3	0	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr19:14591280G>A	uc002myt.2	-	6	762	c.492C>T	c.(490-492)AGC>AGT	p.S164S	GIPC1_uc002myu.2_Silent_p.S164S|GIPC1_uc002myv.2_Silent_p.S67S|GIPC1_uc002myw.2_Silent_p.S67S|GIPC1_uc002myx.2_Silent_p.S164S|GIPC1_uc002myy.2_Silent_p.S67S	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	164	PDZ.				endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0						GGTCGATCACGCTGCCCTCCT	0.682											OREG0025316	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	67					0	0	0	0	A	14591280	A	A	14591280	2	1	87	1	0	0	0	0	0	0	0	1	6429	1078	38	1		1	GIPC1	19	14591280	Silent	SNP	G	TCGA-CN-6996-01A-11D-1912-08	5500449	14591280	44537703	56	17416											
ZNF671	79891	broad.mit.edu	37	chr19	58232120	58232120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cataatcactgctgtgaattCtccagtgtacattaaggtgg	11	13	9	8	0	2	1	1	1	1	0	3	1	2	1	1	2	2	2	1	2	4	4			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr19:58232120C>T	uc002qpz.3	-	4	1433	c.1334G>A	c.(1333-1335)AGA>AAA	p.R445K	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Missense_Mutation_p.R368K|ZNF671_uc010yhf.1_Missense_Mutation_p.R347K	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	445	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GCTGTGAATTCTCCAGTGTAC	0.463													17	57					0	0	0	0	T	58232120	T	T	58232120	3	4	87	1	0	0	0	0	1	0	0	0	18145	913	32	2	274	2	ZNF671	19	58232120	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	43640840	58232120	896863	57	17417											
FAM113A	64773	broad.mit.edu	37	chr20	2816812	2816812	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaggggaggtggcgagggCtgaggaagcgggtagggaaa	12	3	23	3	2	0	2	0	1	0	1	0	6	0	5	0	8	1	2	0	8	4	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr20:2816812C>T	uc002wgz.1	-	7	1487	c.990G>A	c.(988-990)CAG>CAA	p.Q330Q	FAM113A_uc002whb.1_Silent_p.Q181Q|FAM113A_uc002wha.1_Silent_p.Q181Q|FAM113A_uc010zqa.1_Silent_p.Q177Q|FAM113A_uc002whc.1_Silent_p.Q279Q	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773	330							hydrolase activity|protein binding			ovary(2)	2						gtggcgagggctgaggaagcg	0.284													12	40					0	0	0	0	T	2816812	T	T	2816812	2	4	87	1	0	0	0	0	0	0	0	1	5429	796	28	4		4	FAM113A	20	2816812	Silent	SNP	C	TCGA-CN-6996-01A-11D-1912-08		2816812	60208708	58	17418											
PREX1	57580	broad.mit.edu	37	chr20	47266745	47266745	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcttcagttgggctgcaaaCtgagaaagtggaggccgtaa	11	9	13	8	1	2	1	1	1	1	1	2	3	2	2	1	3	2	4	1	3	3	3			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr20:47266745C>T	uc002xtw.1	-	24	2841	c.2818_splice	c.e24-1	p.F940_splice	PREX1_uc002xtv.1_Splice_Site_p.F237_splice	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,						actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GGGCTGCAAACTGAGAAAGTG	0.592													21	63					0	0	0	0	T	47266745	T	T	47266745	5	4	87	1	0	0	0	0	0	0	1	0	12538	579	20	4	2230	4	PREX1	20	47266745	Splice_Site	SNP	C	TCGA-CN-6996-01A-11D-1912-08	44449933	47266745	15758775	59	17419											
GTSE1	51512	broad.mit.edu	37	chr22	46725347	46725347	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttcctctcatcgacttctgCgataccccagaagcacacgt	9	10	6	16	3	2	1	1	0	2	1	5	3	3	1	3	0	3	1	3	0	2	3	rs61737807	byFrequency	TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chr22:46725347C>T	uc011aqy.1	+	11	2231	c.2019C>T	c.(2017-2019)TGC>TGT	p.C673C	GTSE1_uc011aqz.1_Silent_p.C520C|GTSE1_uc003bhn.2_RNA|uc011ara.1_5'Flank|uc003bho.3_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	654					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		TCGACTTCTGCGATACCCCAG	0.507													40	133					0	0	0	0	T	46725347	T	T	46725347	2	4	87	1	0	0	0	0	0	0	0	1	6924	776	27	1		1	GTSE1	22	46725347	Silent	SNP	C	TCGA-CN-6996-01A-11D-1912-08		46725347	4579219	60	17420											
NHS	4810	broad.mit.edu	37	chrX	17710476	17710476	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaccggagccggagcgatcGccgagagcaaagagcagctg	12	2	15	12	5	0	2	0	0	0	2	1	6	0	4	3	2	5	3	3	2	1	0			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chrX:17710476G>A	uc004cxx.2	+	3	1078	c.740G>A	c.(739-741)CGC>CAC	p.R247H	NHS_uc011mix.1_Missense_Mutation_p.R247H|NHS_uc004cxy.2_Missense_Mutation_p.R70H|NHS_uc004cxz.2_Missense_Mutation_p.R70H|NHS_uc004cya.2_5'UTR	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	247						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CGGAGCGATCGCCGAGAGCAA	0.527													28	65					0	0	0	0	A	17710476	A	A	17710476	3	1	87	1	0	0	0	0	1	0	0	0	10465	1087	38	1	788	1	NHS	23	17710476	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08		17710476	137560084	61	17421											
PDHA1	5160	broad.mit.edu	37	chrX	19373621	19373621	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgatttcattcctgggctgaGagtaaggacacctgtggtgg	8	11	14	8	1	1	1	1	1	0	1	2	4	2	2	2	4	0	2	2	4	1	3			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chrX:19373621G>C	uc004czg.3	+	7	903	c.758G>C	c.(757-759)AGA>ACA	p.R253T	PDHA1_uc004czh.3_Missense_Mutation_p.R288T|PDHA1_uc011mjc.1_Missense_Mutation_p.R257T|PDHA1_uc011mjd.1_Missense_Mutation_p.R219T|PDHA1_uc010nfk.2_Missense_Mutation_p.R250T|PDHA1_uc010nfl.2_Missense_Mutation_p.R44T	NM_000284	NP_000275	P08559	ODPA_HUMAN	pyruvate dehydrogenase E1 alpha 1 precursor	253					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)	1	Hepatocellular(33;0.183)				NADH(DB00157)	CCTGGGCTGAGAGTAAGGACA	0.512													8	126					0	0	0	0	C	19373621	C	C	19373621	3	2	87	1	0	0	0	0	1	0	0	0	11718	956	33	2	923	2	PDHA1	23	19373621	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08	1663145	19373621	135896939	62	17422											
ZNF157	7712	broad.mit.edu	37	chrX	47272940	47272940	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacctcacagaacatcagAgaactcacataggctggtcc	14	6	7	14	0	3	2	3	0	0	2	4	3	4	2	2	2	2	1	2	2	3	1			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chrX:47272940A>G	uc004dhr.1	+	4	1537	c.1468A>G	c.(1468-1470)AGA>GGA	p.R490G		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	490	C2H2-type 12.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGAACATCAGAGAACTCACAT	0.488													14	46					0	0	0	0	G	47272940	G	G	47272940	3	3	87	1	0	0	0	0	1	0	0	0	17804	296	11	5	1482	5	ZNF157	23	47272940	Missense_Mutation	SNP	A	TCGA-CN-6996-01A-11D-1912-08	27899319	47272940	107997620	63	17423											
TEX11	56159	broad.mit.edu	37	chrX	69826836	69826836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaagtataaaaaactctctCatcatcactggatctttgtc	14	13	5	9	0	5	0	3	0	2	0	7	2	5	1	0	1	1	1	0	1	5	3			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chrX:69826836C>T	uc004dyl.2	-	24	2130	c.1968G>A	c.(1966-1968)ATG>ATA	p.M656I	TEX11_uc004dyk.2_Missense_Mutation_p.M331I|TEX11_uc004dym.2_Missense_Mutation_p.M641I	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	656							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					AAAACTCTCTCATCATCACTG	0.318													3	30					0	0	0	0	T	69826836	T	T	69826836	3	4	87	1	0	0	0	0	1	0	0	0	15840	826	29	2	886	2	TEX11	23	69826836	Missense_Mutation	SNP	C	TCGA-CN-6996-01A-11D-1912-08	22553896	69826836	85443724	64	17424											
ZBTB33	10009	broad.mit.edu	37	chrX	119388597	119388597	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatcggtgaagatacttatGatatagtgatccctgtcaaa	14	13	8	6	1	1	4	1	3	0	1	3	4	2	4	1	1	1	0	1	1	7	5			TCGA-CN-6996-01A-11D-1912-08	TCGA-CN-6996-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c063bec5-c716-4ea2-843a-e9f0bec3b540	5a2e6c40-39c0-4385-923a-10c862ad731a	g.chrX:119388597G>C	uc004esn.1	+	2	1555	c.1327G>C	c.(1327-1329)GAT>CAT	p.D443H	ZBTB33_uc010nqm.1_Missense_Mutation_p.D443H	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	443					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AGATACTTATGATATAGTGAT	0.413													13	85					0	0	0	0	C	119388597	C	C	119388597	3	2	87	1	0	0	0	0	1	0	0	0	17603	1290	45	2	1329	2	ZBTB33	23	119388597	Missense_Mutation	SNP	G	TCGA-CN-6996-01A-11D-1912-08	49561761	119388597	35881963	65	17425											
NADK	65220	broad.mit.edu	37	chr1	1686106	1686106	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccttcaccaccctgaccttCagccgactccggagaacaac	10	7	6	18	2	2	2	2	1	0	1	4	4	4	2	6	1	3	0	6	1	2	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:1686106C>T	uc009vkw.2	-	8	841	c.720G>A	c.(718-720)CTG>CTA	p.L240L	NADK_uc001aic.2_Silent_p.L240L|NADK_uc001aid.3_Silent_p.L240L|NADK_uc001aie.2_Silent_p.L385L|NADK_uc010nyv.1_Silent_p.L208L|NADK_uc009vkx.1_Silent_p.L118L	NM_023018	NP_075394	O95544	NADK_HUMAN	NAD kinase	240					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		CCCTGACCTTCAGCCGACTCC	0.647													60	22					0	0	0	0	T	1686106	T	T	1686106	2	4	88	1	0	0	0	0	0	0	0	1	10190	813	29	2		2	NADK	1	1686106	Silent	SNP	C	TCGA-CN-6997-01A-11D-2012-08		1686106	247564515	1	17426											
ENO1	2023	broad.mit.edu	37	chr1	8926383	8926385	+	In_Frame_Del	DEL	CCA	-	-																															agcaaacccgccttcatcccCcacattggtggcatctttcc																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:8926383_8926385delCCA	uc001apj.1	-	7	771_773	c.620_622delTGG	c.(619-624)GTGGGG>GGG	p.V207del	ENO1_uc001api.1_In_Frame_Del_p.V111del|ENO1_uc001apk.1_In_Frame_Del_p.V152del|ENO1_uc001apl.1_In_Frame_Del_p.V207del|ENO1_uc009vmi.1_In_Frame_Del_p.V164del|ENO1_uc009vmj.1_In_Frame_Del_p.V207del|ENO1_uc009vmk.1_In_Frame_Del_p.V81del|ENO1_uc009vml.1_In_Frame_Del_p.V207del	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	207	Required for repression of c-myc promoter activity.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CCTTCATCCCCCACATTGGTGGC	0.552													---	---	---								-	8926385	-	-	8926383	7	5	88	1	0	1	0	1	0	0	0	0	5145	623	22	0	706	0	ENO1	1	8926383	In_Frame_Del	DEL	CCA	TCGA-CN-6997-01A-11D-2012-08	7240277	8926383	240324238	2	17427											
SPEN	23013	broad.mit.edu	37	chr1	16258889	16258889	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaagatgctggcacagacAaaaacccccctgaaaccgcc	16	3	8	14	1	0	3	0	1	0	2	0	4	0	3	5	1	3	2	5	1	5	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:16258889A>T	uc001axk.1	+	11	6358	c.6154A>T	c.(6154-6156)AAA>TAA	p.K2052*	SPEN_uc010obp.1_Nonsense_Mutation_p.K2011*	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2052					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGGCACAGACAAAAACCCCCC	0.502													28	10					0	0	0	0	T	16258889	T	T	16258889	4	4	88	1	0	0	0	0	0	1	0	0	15104	131	5	5	6196	5	SPEN	1	16258889	Nonsense_Mutation	SNP	A	TCGA-CN-6997-01A-11D-2012-08	7332506	16258889	232991732	3	17428											
NBPF1	55672	broad.mit.edu	37	chr1	16893786	16893786	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaaggagttgaataacaTctatccagtgagtcctgcaa	13	10	9	9	0	1	3	0	3	1	0	3	4	3	4	3	1	2	2	3	1	5	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:16893786T>A	uc009vos.1	-	26	3840	c.2952A>T	c.(2950-2952)AGA>AGT	p.R984S	NBPF1_uc009vot.1_Missense_Mutation_p.R367S|NBPF1_uc001ayz.1_Missense_Mutation_p.R367S|NBPF1_uc010oce.1_Missense_Mutation_p.R638S	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	984	NBPF 6.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TTGAATAACATCTATCCAGTG	0.493													66	656					0	0	0	0	A	16893786	A	A	16893786	3	1	88	1	0	0	0	0	1	0	0	0	10245	1432	50	5	717	5	NBPF1	1	16893786	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	634897	16893786	232356835	4	17429											
ZNF683	257101	broad.mit.edu	37	chr1	26691127	26691127	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcaaggctgcggtgcctgTctgggaactcaatgggaccc	8	7	15	11	1	2	0	1	0	1	0	2	2	2	2	2	5	3	2	2	5	3	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:26691127T>C	uc001bmg.1	-	4	1028	c.910A>G	c.(910-912)ACA>GCA	p.T304A	ZNF683_uc001bmh.1_Missense_Mutation_p.T304A|ZNF683_uc009vsj.1_Missense_Mutation_p.T304A	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GCGGTGCCTGTCTGGGAACTC	0.577													3	130					0	0	0	0	C	26691127	C	C	26691127	3	2	88	1	0	0	0	0	1	0	0	0	18157	1667	58	5	616	5	ZNF683	1	26691127	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	9797341	26691127	222559494	5	17430											
MANEAL	149175	broad.mit.edu	37	chr1	38265848	38265848	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgctgggcggagcacttcatCaaagagaaggagcagtggct	11	6	15	9	2	2	1	2	0	0	1	2	4	2	3	0	4	2	4	0	4	2	1			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:38265848C>G	uc001cby.2	+	4	1428	c.1347C>G	c.(1345-1347)ATC>ATG	p.I449M	MANEAL_uc001cbx.2_3'UTR|MANEAL_uc001cbz.2_Missense_Mutation_p.I227M	NM_001113482	NP_001106954	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like isoform 3	449	Lumenal (Potential).					Golgi membrane|integral to membrane	hydrolase activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AGCACTTCATCAAAGAGAAGG	0.582													44	18					0	0	0	0	G	38265848	G	G	38265848	3	3	88	1	0	0	0	0	1	0	0	0	9275	816	29	2	1361	2	MANEAL	1	38265848	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	11574721	38265848	210984773	6	17431											
MSH4	4438	broad.mit.edu	37	chr1	76276476	76276476	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccaagttgttcactctgaTcacagaaaatttcaaggtaa	15	11	6	9	0	4	2	3	1	1	1	4	2	4	2	1	1	0	3	1	1	5	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:76276476T>C	uc001dhd.1	+	4	724	c.683T>C	c.(682-684)ATC>ACC	p.I228T		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	228					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TTCACTCTGATCACAGAAAAT	0.264								MMR					27	11					0	0	0	0	C	76276476	C	C	76276476	3	2	88	1	0	0	0	0	1	0	0	0	9925	1435	50	5	697	5	MSH4	1	76276476	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	38010628	76276476	172974145	7	17432											
BCL10	8915	broad.mit.edu	37	chr1	85733454	85733454	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagtgtagttgaagagaaGatggtattttcagttctgcc	11	13	13	4	0	2	3	1	1	1	2	2	5	2	4	1	2	1	4	1	2	5	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:85733454G>A	uc001dkz.2	-	4	1263	c.558C>T	c.(556-558)ATC>ATT	p.I186I		NM_003921	NP_003912	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	186					apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			lung(2)	2				all cancers(265;0.0114)|Epithelial(280;0.0311)		TTGAAGAGAAGATGGTATTTT	0.458			T	IGH@	MALT 								19	10					0	0	0	0	A	85733454	A	A	85733454	2	1	88	1	0	0	0	0	0	0	0	1	1364	932	33	2		2	BCL10	1	85733454	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08	9456978	85733454	163517167	8	17433											
BRDT	676	broad.mit.edu	37	chr1	92446620	92446620	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaagagagccttctctgagCaattccaatcctgatgagat	12	11	8	10	0	2	4	1	3	1	2	5	6	4	4	3	0	2	1	3	0	3	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:92446620C>A	uc001dok.3	+	10	1984	c.1635C>A	c.(1633-1635)AGC>AGA	p.S545R	BRDT_uc001dol.3_Missense_Mutation_p.S545R|BRDT_uc010osz.1_Missense_Mutation_p.S549R|BRDT_uc009wdf.2_Missense_Mutation_p.S472R|BRDT_uc010ota.1_Missense_Mutation_p.S499R|BRDT_uc010otb.1_Missense_Mutation_p.S499R|BRDT_uc001dom.3_Missense_Mutation_p.S545R	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	545					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		CTTCTCTGAGCAATTCCAATC	0.368													29	11					1.50538e-07	7.82966e-07	1	0	A	92446620	A	A	92446620	3	1	88	1	0	0	0	0	1	0	0	0	1513	709	25	4	1669	4	BRDT	1	92446620	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	6713166	92446620	156804001	9	17434											
SLC19A2	10560	broad.mit.edu	37	chr1	169446399	169446399	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggctgagcttaccggttcCtccacgggaggctcctccat	7	9	11	14	2	0	1	0	1	0	0	4	2	4	2	5	4	2	4	5	4	2	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:169446399C>A	uc001gge.3	-	2	1005	c.801G>T	c.(799-801)GAG>GAT	p.E267D	SLC19A2_uc001ggf.3_Intron	NM_006996	NP_008927	O60779	S19A2_HUMAN	solute carrier family 19, member 2	267	Cytoplasmic (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity				0	all_hematologic(923;0.208)					TTACCGGTTCCTCCACGGGAG	0.478													56	79					5.73376e-24	3.15866e-23	1	0	A	169446399	A	A	169446399	3	1	88	1	0	0	0	0	1	0	0	0	14494	680	24	4	712	4	SLC19A2	1	169446399	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	76999779	169446399	79804222	10	17435											
F5	2153	broad.mit.edu	37	chr1	169511140	169511140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaccaacgaatgcttaagtCttctttctgaaaatgtgttg	11	14	8	8	1	3	1	0	1	3	0	3	2	3	1	1	0	2	3	1	0	5	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:169511140C>T	uc001ggg.1	-	13	3333	c.3188G>A	c.(3187-3189)AGA>AAA	p.R1063K		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1063	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ATGCTTAAGTCTTCTTTCTGA	0.423													66	130					0	0	0	0	T	169511140	T	T	169511140	3	4	88	1	0	0	0	0	1	0	0	0	5373	913	32	2	3538	2	F5	1	169511140	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	64741	169511140	79739481	11	17436											
LAD1	3898	broad.mit.edu	37	chr1	201356297	201356297	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcacctctgcttcttccacGctcggtagtctgaatcagaa	8	11	9	13	2	4	2	1	1	3	1	6	2	5	2	2	2	1	4	2	2	3	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:201356297G>A	uc001gwm.2	-	3	427	c.192C>T	c.(190-192)AGC>AGT	p.S64S	LAD1_uc009wzu.1_Silent_p.S86S	NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	64						basement membrane	structural molecule activity				0						CTTCTTCCACGCTCGGTAGTC	0.557													21	47					0	0	0	0	A	201356297	A	A	201356297	2	1	88	1	0	0	0	0	0	0	0	1	8639	1078	38	1		1	LAD1	1	201356297	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08	31845157	201356297	47894324	12	17437											
GNPAT	8443	broad.mit.edu	37	chr1	231406686	231406686	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataggaaccagctgctcaacAtttttgtgcgcccatcctta	10	12	7	12	1	1	0	1	0	0	0	2	1	2	1	3	1	5	2	3	1	4	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:231406686A>G	uc001hup.3	+	10	1668	c.1462A>G	c.(1462-1464)ATT>GTT	p.I488V	GNPAT_uc009xfp.2_Missense_Mutation_p.I427V	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	488					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				GCTGCTCAACATTTTTGTGCG	0.453													68	92					0	0	0	0	G	231406686	G	G	231406686	3	3	88	1	0	0	0	0	1	0	0	0	6578	217	8	5	1500	5	GNPAT	1	231406686	Missense_Mutation	SNP	A	TCGA-CN-6997-01A-11D-2012-08	30050389	231406686	17843935	13	17438											
ZNF238	10472	broad.mit.edu	37	chr1	244217124	244217125	+	Frame_Shift_Ins	INS	-	A	A																															tggagtttccagaccatagtINSagacatttgctacagtgtct																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:244217124_244217125insA	uc001iae.2	+	1	543_544	c.21_22insA	c.(19-24)AGTAGAfs	p.S7fs	ZNF238_uc001iad.3_Frame_Shift_Ins_p.S16fs|ZNF238_uc001iaf.1_Frame_Shift_Ins_p.S7fs	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	7_8					negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			CAGACCATAGTAGACATTTGCT	0.51													---	---	---								A	244217125	A	A	244217124	7	5	88	1	0	1	1	0	0	0	0	0	17857	1635	57	0	54	0	ZNF238	1	244217124	Frame_Shift_Ins	INS	-	TCGA-CN-6997-01A-11D-2012-08	12810438	244217124	5033497	14	17439											
ZNF695	57116	broad.mit.edu	37	chr1	247150864	247150864	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagggtttctctctactaTgaattctcttgtgttgagta	7	19	9	6	0	3	2	0	2	3	0	5	2	3	2	0	1	1	4	0	1	5	8			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:247150864T>C	uc009xgu.2	-	4	1098	c.953A>G	c.(952-954)CAT>CGT	p.H318R	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron|ZNF695_uc009xgt.1_Intron|ZNF695_uc001ibx.2_Intron|ZNF695_uc001iby.2_Intron	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	318	C2H2-type 6.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTCTCTACTATGAATTCTCTT	0.348													9	13					0	0	0	0	C	247150864	C	C	247150864	3	2	88	1	0	0	0	0	1	0	0	0	18165	1464	51	5	598	5	ZNF695	1	247150864	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	2933740	247150864	2099757	15	17440											
ATAD2B	54454	broad.mit.edu	37	chr2	24056880	24056881	+	Missense_Mutation	DNP	CC	AG	AG																															agtcaagtctgtttgtagcaCcaataacaacaatttcaccc																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:24056880_24056881CC>AG	uc002rek.3	-	14	1930_1931	c.1636_1637GG>CT	c.(1636-1638)GGT>CTT	p.G546L	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rej.3_5'Flank	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	546							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTTTGTAGCACCAATAACAACA	0.381													13	24					0	0	0	0	AG	24056881	AG	AG	24056880	3	1	88	1	0	0	0	0	1	0	0	0	1074	507	18	4	2799	4	ATAD2B	2	24056880	Missense_Mutation	DNP	CC	TCGA-CN-6997-01A-11D-2012-08		24056880	219142493	16	17441											
REG3A	5068	broad.mit.edu	37	chr2	79385863	79385863	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctttgggacagcggatccGtgcagagggcagttccctct	6	9	14	12	2	1	1	0	0	1	1	3	3	3	3	3	3	2	3	3	3	0	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:79385863G>T	uc002sod.1	-	2	364	c.109C>A	c.(109-111)CGG>AGG	p.R37R	REG3A_uc002soe.1_Silent_p.R37R|REG3A_uc002sof.1_Silent_p.R37R	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	37					acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						CAGCGGATCCGTGCAGAGGGC	0.552													14	28					1.49906e-05	7.66826e-05	1	0	T	79385863	T	T	79385863	2	4	88	1	0	0	0	0	0	0	0	1	13277	1144	40	3		3	REG3A	2	79385863	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08	55328983	79385863	163813510	17	17442											
SLC9A2	6549	broad.mit.edu	37	chr2	103274384	103274384	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcttaatctcagctgtCgatcctgtggctgtgcttgc	5	13	12	11	1	1	0	1	0	1	0	4	1	2	0	1	2	4	5	1	2	1	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:103274384C>A	uc002tca.2	+	2	793	c.651C>A	c.(649-651)GTC>GTA	p.V217V		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	217	Helical; Name=F/M5A; (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						TCTCAGCTGTCGATCCTGTGG	0.498													108	148					3.11409e-38	1.78964e-37	1	0	A	103274384	A	A	103274384	2	1	88	1	0	0	0	0	0	0	0	1	14776	871	31	3		3	SLC9A2	2	103274384	Silent	SNP	C	TCGA-CN-6997-01A-11D-2012-08	23888521	103274384	139924989	18	17443											
SAP130	79595	broad.mit.edu	37	chr2	128747419	128747419	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtctgagctgtgatggcaGagtttggagcctgagctgaa	9	10	15	7	0	1	5	0	4	1	1	1	6	1	6	1	2	3	4	1	2	1	1			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:128747419G>C	uc002tpp.2	-	13	1709	c.1577C>G	c.(1576-1578)TCT>TGT	p.S526C	SAP130_uc002tpn.2_Missense_Mutation_p.S287C|SAP130_uc002tpo.2_Missense_Mutation_p.S271C|SAP130_uc010fmd.2_Missense_Mutation_p.S526C|SAP130_uc002tpq.1_Missense_Mutation_p.S499C	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	526					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TGTGATGGCAGAGTTTGGAGC	0.443													19	29					0	0	0	0	C	128747419	C	C	128747419	3	2	88	1	0	0	0	0	1	0	0	0	13896	942	33	2	1710	2	SAP130	2	128747419	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	25473035	128747419	114451954	19	17444											
NEB	4703	broad.mit.edu	37	chr2	152534129	152534129	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggaccataactggggagtCcacaatgctggtaaatttga	12	10	11	8	0	0	1	0	1	0	0	1	3	1	3	2	4	2	2	2	4	4	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:152534129C>A	uc010fnx.2	-	34	3915	c.3724G>T	c.(3724-3726)GAC>TAC	p.D1242Y		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1242	Nebulin 31.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACTGGGGAGTCCACAATGCTG	0.443													35	74					3.90053e-15	2.11127e-14	1	0	A	152534129	A	A	152534129	3	1	88	1	0	0	0	0	1	0	0	0	10356	855	30	2	22558	2	NEB	2	152534129	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	23786710	152534129	90665244	20	17445											
XIRP2	129446	broad.mit.edu	37	chr2	168103945	168103945	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttagtagaagaaagaactGaggttaatcttccaaaagcc	17	10	8	6	0	1	4	0	1	1	3	2	4	2	4	2	1	2	2	2	1	8	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:168103945G>C	uc002udx.2	+	8	6061	c.6043G>C	c.(6043-6045)GAG>CAG	p.E2015Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E1840Q|XIRP2_uc010fpq.2_Missense_Mutation_p.E1793Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1840					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGAAAGAACTGAGGTTAATCT	0.438													24	30					0	0	0	0	C	168103945	C	C	168103945	3	2	88	1	0	0	0	0	1	0	0	0	17498	1291	45	2	6073	2	XIRP2	2	168103945	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	15569816	168103945	75095428	21	17446											
G6PC2	57818	broad.mit.edu	37	chr2	169764494	169764494	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttattttatgtgctgtctTtttgtaaaagtgcatccatt	9	21	6	5	0	1	0	0	0	1	0	2	0	2	0	1	0	2	3	1	0	4	8			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:169764494T>A	uc002uem.2	+	5	1065	c.973T>A	c.(973-975)TTT>ATT	p.F325I	G6PC2_uc002uen.2_3'UTR|G6PC2_uc010fpv.2_Missense_Mutation_p.F209I	NM_021176	NP_066999	Q9NQR9	G6PC2_HUMAN	islet-specific glucose-6-phosphatase-related	325	Helical; (Potential).				gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			pancreas(1)	1						TGTGCTGTCTTTTTGTAAAAG	0.433													23	138					0	0	0	0	A	169764494	A	A	169764494	3	1	88	1	0	0	0	0	1	0	0	0	6178	1841	64	5	991	5	G6PC2	2	169764494	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	1660549	169764494	73434879	22	17447											
TTN	7273	broad.mit.edu	37	chr2	179443989	179443989	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctagtgtcagttgctagagGatcttcccctttcttccagg	6	15	9	11	0	4	1	1	0	3	1	6	2	6	2	3	2	1	2	3	2	2	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:179443989G>T	uc010zfg.1	-	269	60288	c.60064C>A	c.(60064-60066)CCT>ACT	p.P20022T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P13717T|TTN_uc010zfi.1_Missense_Mutation_p.P13650T|TTN_uc010zfj.1_Missense_Mutation_p.P13525T|uc002umv.1_Missense_Mutation_p.G72V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20949							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGCTAGAGGATCTTCCCCT	0.433													39	63					1.58521e-26	8.89052e-26	1	0	T	179443989	T	T	179443989	3	4	88	1	0	0	0	0	1	0	0	0	16803	1174	41	2	40383	2	TTN	2	179443989	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	9679495	179443989	63755384	23	17448											
TTN	7273	broad.mit.edu	37	chr2	179452482	179452482	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagggcatcctgctctcactAtgaccagtttcctcatgctg	7	13	8	13	0	2	1	2	1	1	0	5	1	4	1	3	1	2	4	3	1	2	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:179452482A>G	uc010zfg.1	-	255	56074	c.55850T>C	c.(55849-55851)ATA>ACA	p.I18617T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I12312T|TTN_uc010zfi.1_Missense_Mutation_p.I12245T|TTN_uc010zfj.1_Missense_Mutation_p.I12120T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19544							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTCTCACTATGACCAGTTT	0.433													24	41					0	0	0	0	G	179452482	G	G	179452482	3	3	88	1	0	0	0	0	1	0	0	0	16803	449	16	5	44653	5	TTN	2	179452482	Missense_Mutation	SNP	A	TCGA-CN-6997-01A-11D-2012-08	8493	179452482	63746891	24	17449											
TTN	7273	broad.mit.edu	37	chr2	179604933	179604933	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacgttgtcagaatgctcttCtttgagcagtacctgctttt	7	16	8	10	1	3	2	1	1	2	1	3	2	3	2	1	0	4	5	1	0	2	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:179604933C>G	uc010zfh.1	-	46	12738	c.12514G>C	c.(12514-12516)GAA>CAA	p.E4172Q	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E4105Q|TTN_uc010zfj.1_Missense_Mutation_p.E3980Q|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAATGCTCTTCTTTGAGCAGT	0.473													52	72					0	0	0	0	G	179604933	G	G	179604933	3	3	88	1	0	0	0	0	1	0	0	0	16803	922	32	2	91762	2	TTN	2	179604933	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	152451	179604933	63594440	25	17450											
ITGAV	3685	broad.mit.edu	37	chr2	187506311	187506311	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatctggaccaggatggtttCaatggtaagatcaaagttta	13	12	11	5	0	3	1	2	0	1	1	3	4	3	3	1	4	0	3	1	4	4	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:187506311C>T	uc002upq.2	+	12	1431	c.1155C>T	c.(1153-1155)TTC>TTT	p.F385F	ITGAV_uc010frs.2_Silent_p.F349F|ITGAV_uc010zfv.1_Silent_p.F339F	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	385	FG-GAP 6.|Potential.|Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		AGGATGGTTTCAATGGTAAGA	0.463													59	77					0	0	0	0	T	187506311	T	T	187506311	2	4	88	1	0	0	0	0	0	0	0	1	7927	825	29	2		2	ITGAV	2	187506311	Silent	SNP	C	TCGA-CN-6997-01A-11D-2012-08	7901378	187506311	55693062	26	17451											
TTLL4	9654	broad.mit.edu	37	chr2	219612322	219612322	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcctttgtcctatgtaggtAtctacacaaaccctacctca	10	12	6	13	0	2	0	1	0	1	0	3	0	3	0	4	2	3	2	4	2	6	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:219612322A>G	uc002viy.2	+	11	2622	c.2252A>G	c.(2251-2253)TAT>TGT	p.Y751C	TTLL4_uc010zkl.1_Missense_Mutation_p.Y586C|TTLL4_uc010fvx.2_Missense_Mutation_p.Y687C|TTLL4_uc010zkm.1_5'UTR	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	751	TTL.				protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		CTATGTAGGTATCTACACAAA	0.478													54	23					0	0	0	0	G	219612322	G	G	219612322	3	3	88	1	0	0	0	0	1	0	0	0	16797	449	16	5	2286	5	TTLL4	2	219612322	Missense_Mutation	SNP	A	TCGA-CN-6997-01A-11D-2012-08	32106011	219612322	23587051	27	17452											
GRM2	2912	broad.mit.edu	37	chr3	51743449	51743449	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacagtgatgtctccatccaGgtacgtggaagccacccaaa	12	8	9	12	1	1	1	0	1	1	0	3	2	2	2	4	2	3	1	4	2	4	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:51743449G>A	uc010hlv.2	+	2	689	c.450G>A	c.(448-450)CAG>CAA	p.Q150Q	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	150	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TCTCCATCCAGGTACGTGGAA	0.582													6	4					0	0	0	0	A	51743449	A	A	51743449	2	1	88	1	0	0	0	0	0	0	0	1	6836	1014	35	4		4	GRM2	3	51743449	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08		51743449	146278981	28	17453											
IMPG2	50939	broad.mit.edu	37	chr3	100963028	100963028	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taagaggtgctttggtaactGagtaatcatcaacaccaggt	13	11	10	7	0	2	2	2	1	0	1	2	2	2	2	1	3	3	3	1	3	4	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:100963028G>C	uc003duq.1	-	13	2350	c.2147C>G	c.(2146-2148)TCA>TGA	p.S716*	IMPG2_uc011bhe.1_Nonsense_Mutation_p.S579*	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	716	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TTTGGTAACTGAGTAATCATC	0.473													14	7					0	0	0	0	C	100963028	C	C	100963028	4	2	88	1	0	0	0	0	0	1	0	0	7768	1294	45	2	1606	2	IMPG2	3	100963028	Nonsense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	49219579	100963028	97059402	29	17454											
KIAA1407	57577	broad.mit.edu	37	chr3	113721347	113721347	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcttctctgccaagatccGcctacattcagctcgttgaa	8	13	6	14	2	3	2	1	1	2	1	6	2	4	2	3	0	3	2	3	0	3	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:113721347G>A	uc003eax.2	-	12	2164	c.2017C>T	c.(2017-2019)CGG>TGG	p.R673W	KIAA1407_uc011bin.1_RNA	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	673	Potential.									ovary(2)	2						GCCAAGATCCGCCTACATTCA	0.328													38	8					0	0	0	0	A	113721347	A	A	113721347	3	1	88	1	0	0	0	0	1	0	0	0	8268	1086	38	1	817	1	KIAA1407	3	113721347	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	12758319	113721347	84301083	30	17455											
SLCO2A1	6578	broad.mit.edu	37	chr3	133666147	133666147	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggtggagcatcccatgaaGaacaaaggaacacaaaggat	17	4	13	7	0	0	2	0	1	0	1	1	5	1	5	1	5	3	1	1	5	5	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:133666147G>C	uc003eqa.3	-	9	1522	c.1248C>G	c.(1246-1248)TTC>TTG	p.F416L	SLCO2A1_uc003eqb.3_Missense_Mutation_p.F340L|SLCO2A1_uc011blv.1_Missense_Mutation_p.F235L	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	416	Extracellular (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						ATCCCATGAAGAACAAAGGAA	0.493													36	55					0	0	0	0	C	133666147	C	C	133666147	3	2	88	1	0	0	0	0	1	0	0	0	14790	933	33	2	707	2	SLCO2A1	3	133666147	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	19944800	133666147	64356283	31	17456											
ACPL2	92370	broad.mit.edu	37	chr3	140998227	140998227	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctctcgcgcaggtcatgcCccgcatcattttaagctggt	6	13	9	13	3	3	0	2	0	1	0	5	0	3	0	2	2	2	3	2	2	1	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:140998227C>T	uc003etu.2	+	6	545	c.246C>T	c.(244-246)GCC>GCT	p.A82A	ACPL2_uc003etv.2_Silent_p.A82A|ACPL2_uc011bna.1_Silent_p.A44A|ACPL2_uc011bnb.1_Silent_p.A65A	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2 precursor	82						extracellular region	acid phosphatase activity			skin(1)	1						CAGGTCATGCCCCGCATCATT	0.498											OREG0015847	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	145	28					0	0	0	0	T	140998227	T	T	140998227	2	4	88	1	0	0	0	0	0	0	0	1	166	610	22	4		4	ACPL2	3	140998227	Silent	SNP	C	TCGA-CN-6997-01A-11D-2012-08	7332080	140998227	57024203	32	17457											
ECE2	9718	broad.mit.edu	37	chr3	183995809	183995809	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcgcattgaggagctgggagCccagccactgagagacctca	10	5	14	12	1	1	3	1	2	0	1	1	6	1	5	3	2	3	2	3	2	0	1			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:183995809C>A	uc003fni.3	+	5	967	c.929C>A	c.(928-930)GCC>GAC	p.A310D	ECE2_uc011brg.1_Missense_Mutation_p.A238D|ECE2_uc011brh.1_Missense_Mutation_p.A163D|ECE2_uc003fnl.3_Missense_Mutation_p.A238D|ECE2_uc003fnm.3_Missense_Mutation_p.A192D|ECE2_uc003fnk.3_Missense_Mutation_p.A163D|ECE2_uc011bri.1_Missense_Mutation_p.A225D|ECE2_uc010hxv.2_5'UTR	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	310	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GAGCTGGGAGCCCAGCCACTG	0.577													120	13					1.37143e-49	7.93047e-49	1	0	A	183995809	A	A	183995809	3	1	88	1	0	0	0	0	1	0	0	0	4912	739	26	4	1511	4	ECE2	3	183995809	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	42997582	183995809	14026621	33	17458											
C4orf35	85438	broad.mit.edu	37	chr4	71201610	71201610	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agataaacgggaagatactcTgctaactgatgaagaaacta	18	8	9	6	1	1	5	0	2	1	3	1	6	1	6	0	1	5	1	0	1	8	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr4:71201610T>C	uc003hff.2	+	1	940	c.854T>C	c.(853-855)CTG>CCG	p.L285P		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	285						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				GAAGATACTCTGCTAACTGAT	0.418													19	12					0	0	0	0	C	71201610	C	C	71201610	3	2	88	1	0	0	0	0	1	0	0	0	2275	1580	55	5	856	5	C4orf35	4	71201610	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08		71201610	119952666	34	17459											
TIFA	92610	broad.mit.edu	37	chr4	113199415	113199415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagtataatgacagatgttgGaatttcggccaaatttcacc	14	12	8	7	1	1	2	1	1	0	1	2	3	1	3	2	2	0	2	2	2	5	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr4:113199415G>A	uc003ial.2	-	2	440	c.158C>T	c.(157-159)TCC>TTC	p.S53F		NM_052864	NP_443096	Q96CG3	TIFA_HUMAN	TRAF-interacting protein with a	53	FHA.						protein binding			breast(1)	1		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00172)		ACAGATGTTGGAATTTCGGCC	0.403													41	24					0	0	0	0	A	113199415	A	A	113199415	3	1	88	1	0	0	0	0	1	0	0	0	15960	1174	41	2	400	2	TIFA	4	113199415	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	41997805	113199415	77954861	35	17460											
USP38	84640	broad.mit.edu	37	chr4	144106780	144106780	+	Frame_Shift_Del	DEL	G	-	-																															caggaccctttccagcggcaGgtggggcaccaggtgctgga																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr4:144106780delG	uc003ijb.2	+	1	711	c.177delG	c.(175-177)CAGfs	p.Q59fs	USP38_uc003ija.3_Frame_Shift_Del_p.Q59fs|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	59					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					TCCAGCGGCAGGTGGGGCACC	0.627													---	---	---								-	144106780	-	-	144106780	7	5	88	1	0	1	0	1	0	0	0	0	17137	991	35	0	179	0	USP38	4	144106780	Frame_Shift_Del	DEL	G	TCGA-CN-6997-01A-11D-2012-08	30907365	144106780	47047496	36	17461											
ADCY2	108	broad.mit.edu	37	chr5	7789843	7789843	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccatggagaacctgaaccGcgtgctgctggagaacgtgc	10	6	14	11	3	0	3	0	1	0	2	0	6	0	3	3	2	6	2	3	2	3	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:7789843G>A	uc003jdz.1	+	20	2625	c.2558G>A	c.(2557-2559)CGC>CAC	p.R853H	ADCY2_uc011cmo.1_Missense_Mutation_p.R673H|ADCY2_uc010itm.1_Missense_Mutation_p.R49H	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	853	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AACCTGAACCGCGTGCTGCTG	0.532													35	77					0	0	0	0	A	7789843	A	A	7789843	3	1	88	1	0	0	0	0	1	0	0	0	294	1087	38	1	2636	1	ADCY2	5	7789843	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08		7789843	173125417	37	17462											
PRDM9	56979	broad.mit.edu	37	chr5	23526620	23526620	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcagagggagatttcaaggGccttttctagcccacccaaa	11	8	11	11	0	2	2	1	0	1	2	2	3	2	2	3	3	1	1	3	3	3	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:23526620G>A	uc003jgo.2	+	11	1605	c.1423G>A	c.(1423-1425)GCC>ACC	p.A475T		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	475					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GATTTCAAGGGCCTTTTCTAG	0.453										HNSCC(3;0.000094)			10	23					0	0	0	0	A	23526620	A	A	23526620	3	1	88	1	0	0	0	0	1	0	0	0	12525	1203	42	4	1461	4	PRDM9	5	23526620	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	15736777	23526620	157388640	38	17463											
PCDHGA12	26025	broad.mit.edu	37	chr5	140812032	140812032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtaccccgccctccccaCggacggttccactggcgtgg	4	7	11	19	4	0	0	0	0	0	0	2	1	2	1	7	4	1	2	7	4	1	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:140812032C>T	uc003lkt.1	+	1	1875	c.1706C>T	c.(1705-1707)ACG>ATG	p.T569M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.T569M	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	569	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCTCCCCACGGACGGTTCC	0.677													91	42					0	0	0	0	T	140812032	T	T	140812032	3	4	88	1	0	0	0	0	1	0	0	0	11607	536	19	1	1708	1	PCDHGA12	5	140812032	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	117285412	140812032	40103228	39	17464											
SLIT3	6586	broad.mit.edu	37	chr5	168112761	168112761	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgtaggagtctttgcccacGaagttgacagtgatgagctt	10	11	12	8	2	1	3	0	3	1	0	1	5	1	4	1	1	2	3	1	1	2	4	rs148625020		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:168112761G>A	uc003mab.2	-	31	3906	c.3486C>T	c.(3484-3486)TTC>TTT	p.F1162F	SLIT3_uc010jjg.2_Silent_p.F1169F	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1162	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTTGCCCACGAAGTTGACAG	0.657													24	14					0	0	0	0	A	168112761	A	A	168112761	2	1	88	1	0	0	0	0	0	0	0	1	14805	1049	37	1		1	SLIT3	5	168112761	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08	27300729	168112761	12802499	40	17465											
HIST1H2BG	8339	broad.mit.edu	37	chr6	26216820	26216831	+	In_Frame_Del	DEL	CCTTCTTGGAAC	-	-																															cttctgcgccttggtcacagCcttcttggaacccttcttcg																								rs143774290		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:26216820_26216831delCCTTCTTGGAAC	uc003ngz.2	-	1	42_53	c.41_52delGTTCCAAGAAGG	c.(40-54)GGTTCCAAGAAGGCT>GCT	p.GSKK14del	HIST1H2AE_uc003nha.1_5'Flank	NM_003518	NP_003509	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	14_17					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding	p.K17E(1)		ovary(1)	1		all_hematologic(11;0.196)				TTGGTCACAGCCTTCTTGGAACCCTTCTTCGG	0.491													---	---	---								-	26216831	-	-	26216820	7	5	88	1	0	1	0	1	0	0	0	0	7185	739	26	0	332	0	HIST1H2BG	6	26216820	In_Frame_Del	DEL	CCTTCTTGGAAC	TCGA-CN-6997-01A-11D-2012-08		26216820	144898247	41	17466											
RNF39	80352	broad.mit.edu	37	chr6	30043353	30043353	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagccccgggcccagctcggGcgcatccatggaaagccagg	8	3	14	16	3	0	0	0	0	0	0	2	1	1	1	5	4	3	2	5	4	1	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:30043353G>A	uc003npe.2	-	1	276	c.214C>T	c.(214-216)CCC>TCC	p.P72S	RNF39_uc003npd.2_Missense_Mutation_p.P72S	NM_025236	NP_079512	Q9H2S5	RNF39_HUMAN	ring finger protein 39 isoform 1	72						cytoplasm	zinc ion binding				0						CCCAGCTCGGGCGCATCCATG	0.711													10	7					0	0	0	0	A	30043353	A	A	30043353	3	1	88	1	0	0	0	0	1	0	0	0	13556	1203	42	4	1064	4	RNF39	6	30043353	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	3826533	30043353	141071714	42	17467											
ROS1	6098	broad.mit.edu	37	chr6	117658469	117658469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcaggaccttggctgcatGaagttttaacatggtaaaac	14	10	10	7	0	0	1	0	1	0	0	0	2	0	2	1	3	4	5	1	3	5	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:117658469G>A	uc003pxp.1	-	31	5313	c.5114C>T	c.(5113-5115)TCA>TTA	p.S1705L	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1705	Fibronectin type-III 8.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTGGCTGCATGAAGTTTTAAC	0.308			T	GOPC|ROS1	glioblastoma|NSCLC								30	35					0	0	0	0	A	117658469	A	A	117658469	3	1	88	1	0	0	0	0	1	0	0	0	13596	1294	45	2	1981	2	ROS1	6	117658469	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	87615116	117658469	53456598	43	17468											
SERINC1	57515	broad.mit.edu	37	chr6	122766322	122766322	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatctcacgagagggttcaTacctaaaatttcagggaaaa	15	10	8	8	1	4	1	4	0	1	1	5	3	4	2	1	2	1	1	1	2	5	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:122766322T>C	uc003pyy.1	-	10	1299	c.1229A>G	c.(1228-1230)TAT>TGT	p.Y410C	SERINC1_uc003pyx.1_RNA	NM_020755	NP_065806	Q9NRX5	SERC1_HUMAN	serine incorporator 1	410	Lumenal (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	L-serine transmembrane transporter activity|protein binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.126)		AGAGGGTTCATACCTAAAATT	0.428													17	15					0	0	0	0	C	122766322	C	C	122766322	3	2	88	1	0	0	0	0	1	0	0	0	14144	1406	49	5	136	5	SERINC1	6	122766322	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	5107853	122766322	48348745	44	17469											
LAMA2	3908	broad.mit.edu	37	chr6	129826387	129826387	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaaggaattctttatgtaGatggggcttccaacagaacc	14	10	10	7	0	1	3	0	0	1	3	2	4	2	4	2	3	2	2	2	3	7	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:129826387G>C	uc003qbn.2	+	60	8695	c.8590G>C	c.(8590-8592)GAT>CAT	p.D2864H	LAMA2_uc003qbo.2_Missense_Mutation_p.D2860H|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2864	Laminin G-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCTTTATGTAGATGGGGCTTC	0.413													34	35					0	0	0	0	C	129826387	C	C	129826387	3	2	88	1	0	0	0	0	1	0	0	0	8646	942	33	2	8832	2	LAMA2	6	129826387	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	7060065	129826387	41288680	45	17470											
SAMD3	154075	broad.mit.edu	37	chr6	130505272	130505272	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccacagccatcctcatccagGaaagggtgggcctgcagcag	10	5	12	14	0	1	0	1	0	0	0	3	1	3	1	5	3	3	2	5	3	1	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:130505272G>A	uc003qbv.2	-	8	956	c.630C>T	c.(628-630)TTC>TTT	p.F210F	SAMD3_uc003qbx.2_Silent_p.F210F|SAMD3_uc003qbw.2_Silent_p.F210F|SAMD3_uc010kfg.1_Silent_p.F210F|SAMD3_uc003qby.2_Silent_p.F210F|SAMD3_uc003qbz.1_Silent_p.F169F	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	210										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CCTCATCCAGGAAAGGGTGGG	0.468													26	34					0	0	0	0	A	130505272	A	A	130505272	2	1	88	1	0	0	0	0	0	0	0	1	13885	1165	41	2		2	SAMD3	6	130505272	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08	678885	130505272	40609795	46	17471											
BCLAF1	9774	broad.mit.edu	37	chr6	136582515	136582515	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gagtccatttaggactgctaCctgattttttgaagttaaag	11	15	9	6	0	0	2	0	2	0	0	1	4	1	3	2	1	2	2	2	1	5	7			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:136582515C>A	uc003qgx.1	-	12	2898	c.2645G>T	c.(2644-2646)GGT>GTT	p.G882V	BCLAF1_uc011edb.1_Missense_Mutation_p.G161V|BCLAF1_uc003qgw.1_Missense_Mutation_p.G709V|BCLAF1_uc003qgy.1_Missense_Mutation_p.G831V|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.G880V	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	882					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGGACTGCTACCTGATTTTTT	0.438													55	245					3.4597e-24	1.91725e-23	1	0	A	136582515	A	A	136582515	3	1	88	1	0	0	0	0	1	0	0	0	1385	507	18	4	125	4	BCLAF1	6	136582515	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	6077243	136582515	34532552	47	17472											
TCP10	6953	broad.mit.edu	37	chr6	167790110	167790110	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctggacttctgtcttgaCgtctcccgggaggacttttc	4	14	12	11	2	3	1	0	1	3	0	5	4	3	4	1	3	1	1	1	3	0	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:167790110C>A	uc003qvv.1	-	5	712	c.500G>T	c.(499-501)CGT>CTT	p.R167L	TCP10_uc003qvu.2_Missense_Mutation_p.R167L|TCP10_uc003qvw.2_Missense_Mutation_p.R143L	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10	194						cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		TCTGTCTTGACGTCTCCCGGG	0.507													26	6					9.04072e-19	4.95112e-18	1	0	A	167790110	A	A	167790110	3	1	88	1	0	0	0	0	1	0	0	0	15776	536	19	3	496	3	TCP10	6	167790110	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	31207595	167790110	3324957	48	17473											
TMEM195	392636	broad.mit.edu	37	chr7	15599809	15599809	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctgagattgacgttaaagCatcatccaggcgacctggtg	11	9	12	9	2	1	2	1	2	0	1	2	4	2	2	2	2	2	3	2	2	2	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:15599809C>A	uc003stb.1	-	2	384	c.214G>T	c.(214-216)GCT>TCT	p.A72S		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	72					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						GACGTTAAAGCATCATCCAGG	0.443													85	68					4.45923e-32	2.51608e-31	1	0	A	15599809	A	A	15599809	3	1	88	1	0	0	0	0	1	0	0	0	16183	710	25	4	1171	4	TMEM195	7	15599809	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08		15599809	143538854	49	17474											
ZNF716	441234	broad.mit.edu	37	chr7	57529191	57529191	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatcctcaacccttaagaaaCataagatagttcatactggg	15	11	6	9	0	2	2	2	0	0	2	3	2	3	2	2	1	3	1	2	1	7	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:57529191C>T	uc011kdi.1	+	4	1136	c.1024C>T	c.(1024-1026)CAT>TAT	p.H342Y		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						CCTTAAGAAACATAAGATAGT	0.388													30	16					0	0	0	0	T	57529191	T	T	57529191	3	4	88	1	0	0	0	0	1	0	0	0	18186	478	17	4	1038	4	ZNF716	7	57529191	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	41929382	57529191	101609472	50	17475											
POM121	9883	broad.mit.edu	37	chr7	72413673	72413673	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaagccacggcttcggccttCggcgctcccgccagctcaca	7	6	10	18	5	1	0	1	0	0	0	4	0	2	0	4	3	2	3	4	3	1	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:72413673C>T	uc003twk.2	+	11	3141	c.3141C>T	c.(3139-3141)TTC>TTT	p.F1047F	POM121_uc003twj.2_Silent_p.F782F|POM121_uc010lam.1_Silent_p.F782F	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1047	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				CTTCGGCCTTCGGCGCTCCCG	0.647													7	199					0	0	0	0	T	72413673	T	T	72413673	2	4	88	1	0	0	0	0	0	0	0	1	12294	883	31	1		1	POM121	7	72413673	Silent	SNP	C	TCGA-CN-6997-01A-11D-2012-08	14884482	72413673	86724990	51	17476											
GRM3	2913	broad.mit.edu	37	chr7	86493648	86493648	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaatgggcgggaagtcctcGactccaccacctcatctctg	8	8	10	15	2	2	0	1	0	1	0	6	2	4	1	4	2	0	1	4	2	2	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:86493648G>A	uc003uid.2	+	6	3716	c.2617G>A	c.(2617-2619)GAC>AAC	p.D873N	GRM3_uc010lef.2_Missense_Mutation_p.R515Q|GRM3_uc010leg.2_Missense_Mutation_p.D745N|GRM3_uc010leh.2_Missense_Mutation_p.D465N	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	873	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGAAGTCCTCGACTCCACCAC	0.448													73	122					0	0	0	0	A	86493648	A	A	86493648	3	1	88	1	0	0	0	0	1	0	0	0	6837	1058	37	1	2635	1	GRM3	7	86493648	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	14079975	86493648	72645015	52	17477											
STEAP4	79689	broad.mit.edu	37	chr7	87910251	87910251	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggacaaatcggaactctctCcagttgactgcattgctaac	11	11	8	11	1	1	1	0	1	1	0	4	3	2	3	1	2	4	3	1	2	3	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:87910251C>T	uc003ujs.2	-	4	1233	c.1128G>A	c.(1126-1128)TGG>TGA	p.W376*	STEAP4_uc010lek.2_Nonsense_Mutation_p.W200*	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	376	Ferric oxidoreductase.				fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					GGAACTCTCTCCAGTTGACTG	0.378													45	110					0	0	0	0	T	87910251	T	T	87910251	4	4	88	1	0	0	0	0	0	1	0	0	15346	856	30	2	259	2	STEAP4	7	87910251	Nonsense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	1416603	87910251	71228412	53	17478											
BHLHA15	168620	broad.mit.edu	37	chr7	97841820	97841820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccaggaccctccgggcccGgtggccgtcgtgacagcagc	5	4	16	16	4	0	1	0	1	0	0	2	2	1	2	5	5	2	1	5	5	0	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:97841820G>A	uc003upe.1	+	2	286	c.199G>A	c.(199-201)GGT>AGT	p.G67S	BHLHA15_uc003upf.1_Missense_Mutation_p.G67S	NM_177455	NP_803238	Q7RTS1	BHA15_HUMAN	basic helix-loop-helix family, member a15	67	Basic motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						CTCCGGGCCCGGTGGCCGTCG	0.736													6	10					0	0	0	0	A	97841820	A	A	97841820	3	1	88	1	0	0	0	0	1	0	0	0	1422	1116	39	1	201	1	BHLHA15	7	97841820	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	9931569	97841820	61296843	54	17479											
ZNF394	84124	broad.mit.edu	37	chr7	99097557	99097557	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggggtccggcgaagccgcggGatagttgggctcccaacttc	6	7	16	12	4	0	0	0	0	0	0	3	2	2	1	3	5	2	2	3	5	3	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:99097557G>T	uc003uqs.2	-	1	321	c.160C>A	c.(160-162)CCC>ACC	p.P54T	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Missense_Mutation_p.P54T	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	54					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GAAGCCGCGGGATAGTTGGGC	0.642													43	50					1.15183e-24	6.42129e-24	1	0	T	99097557	T	T	99097557	3	4	88	1	0	0	0	0	1	0	0	0	17947	1174	41	2	1537	2	ZNF394	7	99097557	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	1255737	99097557	60041106	55	17480											
LAMB4	22798	broad.mit.edu	37	chr7	107696109	107696109	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgataatccttgacttttaaGaatttcccagatgggaaaac	14	13	7	7	0	0	4	0	2	0	2	2	5	2	5	2	1	1	0	2	1	5	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:107696109G>C	uc010ljo.1	-	25	3807	c.3723C>G	c.(3721-3723)TTC>TTG	p.F1241L	LAMB4_uc003vey.2_Missense_Mutation_p.F1241L|LAMB4_uc010ljp.1_Missense_Mutation_p.F210L	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1241	Domain II.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TGACTTTTAAGAATTTCCCAG	0.413													49	101					0	0	0	0	C	107696109	C	C	107696109	3	2	88	1	0	0	0	0	1	0	0	0	8653	933	33	2	1602	2	LAMB4	7	107696109	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	8598552	107696109	51442554	56	17481											
DOCK4	9732	broad.mit.edu	37	chr7	111540505	111540505	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgggaagtttcagcagttCagaccacctgggactgttgt	10	11	12	8	0	2	1	2	0	0	1	2	3	2	3	2	2	1	4	2	2	2	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:111540505C>T	uc003vfx.2	-	15	1674	c.1405G>A	c.(1405-1407)GAA>AAA	p.E469K	DOCK4_uc003vfy.2_Missense_Mutation_p.E469K|DOCK4_uc003vga.1_Missense_Mutation_p.E74K	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	469	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TTCAGCAGTTCAGACCACCTG	0.498													14	15					0	0	0	0	T	111540505	T	T	111540505	3	4	88	1	0	0	0	0	1	0	0	0	4711	835	29	2	4647	2	DOCK4	7	111540505	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	3844396	111540505	47598158	57	17482											
TFEC	22797	broad.mit.edu	37	chr7	115624462	115624462	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcaggttgtgaccatttaaGagttggattgatgatctgat	10	15	12	4	0	1	5	0	4	1	1	1	6	1	6	1	2	1	3	1	2	1	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:115624462G>C	uc003vhj.1	-	2	218	c.34C>G	c.(34-36)CTT>GTT	p.L12V	TFEC_uc003vhk.1_Missense_Mutation_p.L12V|TFEC_uc003vhl.3_Missense_Mutation_p.L12V|TFEC_uc011kmw.1_Missense_Mutation_p.L102V	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	12	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			GACCATTTAAGAGTTGGATTG	0.493													54	108					0	0	0	0	C	115624462	C	C	115624462	3	2	88	1	0	0	0	0	1	0	0	0	15868	942	33	2	1037	2	TFEC	7	115624462	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	4083957	115624462	43514201	58	17483											
TUSC3	7991	broad.mit.edu	37	chr8	15601046	15601046	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccttgacaactactgcaGatgccgctatcaccatgggg	9	10	9	13	1	1	2	1	1	0	1	2	2	2	2	3	2	4	2	3	2	3	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr8:15601046G>T	uc003wwt.2	+	8	1073	c.863_splice	c.e8-1	p.N288_splice	TUSC3_uc003wwu.2_Splice_Site_p.N288_splice|TUSC3_uc003wwv.2_Splice_Site_p.N288_splice|TUSC3_uc003www.2_Splice_Site_p.N288_splice|TUSC3_uc003wwx.2_Splice_Site|TUSC3_uc003wwy.2_Splice_Site_p.M267_splice	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a						cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		AACTACTGCAGATGCCGCTAT	0.403													23	137					5.35356e-11	2.83191e-10	1	0	T	15601046	T	T	15601046	5	4	88	1	0	0	0	0	0	0	1	0	16846	956	33	2	892	2	TUSC3	8	15601046	Splice_Site	SNP	G	TCGA-CN-6997-01A-11D-2012-08		15601046	130762976	59	17484											
PKHD1L1	93035	broad.mit.edu	37	chr8	110457673	110457673	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggaaatggcttctatccaGgcaacactacagtcactatt	13	10	7	11	0	2	0	1	0	1	0	3	1	3	1	1	3	2	2	1	3	5	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr8:110457673G>T	uc003yne.2	+	38	5679	c.5575G>T	c.(5575-5577)GGC>TGC	p.G1859C		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1859	Extracellular (Potential).|IPT/TIG 11.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTTCTATCCAGGCAACACTAC	0.502										HNSCC(38;0.096)			39	7					6.97489e-18	3.79744e-17	1	0	T	110457673	T	T	110457673	3	4	88	1	0	0	0	0	1	0	0	0	12027	1000	35	4	5725	4	PKHD1L1	8	110457673	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	94856627	110457673	35906349	60	17485											
FAM84B	157638	broad.mit.edu	37	chr8	127569333	127569333	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtaggtactcagcgccgccGagcccggcgcgaagctcttc	6	7	13	15	6	2	0	1	0	1	0	3	2	2	0	3	2	4	3	3	2	3	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr8:127569333G>A	uc003yrz.1	-	2	586	c.302C>T	c.(301-303)TCG>TTG	p.S101L		NM_174911	NP_777571	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	101						cytoplasm|plasma membrane	protein binding				0	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			CAGCGCCGCCGAGCCCGGCGC	0.657													31	17					0	0	0	0	A	127569333	A	A	127569333	3	1	88	1	0	0	0	0	1	0	0	0	5674	1059	37	1	634	1	FAM84B	8	127569333	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	17111660	127569333	18794689	61	17486											
CDKN2A	1029	broad.mit.edu	37	chr9	21971098	21971098	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgtccaggaagccctccCgggcagcgtcgtgcacgggt	5	6	16	14	5	0	0	0	0	0	0	3	1	2	1	3	3	3	2	3	3	1	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:21971098C>G	uc003zpk.2	-	2	472	c.260G>C	c.(259-261)CGG>CCG	p.R87P	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.P142P	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	87	ANK 3.		R -> P (in CMM2; impairs the function).|R -> W (in CMM2; partial loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.H83fs*2(2)|p.D84_F90del(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.R87W(1)|p.R87L(1)|p.E61_L94del(1)|p.R87Q(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.R87fs(1)|p.E87K(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GAAGCCCTCCCGGGCAGCGTC	0.751		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	3					0	0	0	0	G	21971098	G	G	21971098	3	3	88	1	0	0	0	0	1	0	0	0	3176	652	23	3	218	3	CDKN2A	9	21971098	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08		21971098	119242333	62	17487											
KIAA1161	57462	broad.mit.edu	37	chr9	34371549	34371549	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cggcaggtagctgacctcgcCcgcgtcgaacttgaaggaag	9	6	14	12	5	0	2	0	2	0	0	2	4	0	3	2	3	2	3	2	3	4	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:34371549C>G	uc003zue.3	-	3	1560	c.1393G>C	c.(1393-1395)GGC>CGC	p.G465R		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	465	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CTGACCTCGCCCGCGTCGAAC	0.672													2	7					0	0	0	0	G	34371549	G	G	34371549	3	3	88	1	0	0	0	0	1	0	0	0	8250	623	22	4	755	4	KIAA1161	9	34371549	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	12400451	34371549	106841882	63	17488											
TMEM2	23670	broad.mit.edu	37	chr9	74332991	74332991	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtttgcatcctgatgaggtcGaaatctaggggttaaaaaaa	14	11	11	5	1	1	2	0	2	1	0	3	3	2	2	1	3	1	3	1	3	6	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:74332991G>A	uc011lsa.1	-	13	2812	c.2272C>T	c.(2272-2274)CGA>TGA	p.R758*	TMEM2_uc010mos.2_Nonsense_Mutation_p.R695*|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	758						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TGATGAGGTCGAAATCTAGGG	0.338													27	37					0	0	0	0	A	74332991	A	A	74332991	4	1	88	1	0	0	0	0	0	1	0	0	16187	1066	37	1	1927	1	TMEM2	9	74332991	Nonsense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	39961442	74332991	66880440	64	17489											
VPS13A	23230	broad.mit.edu	37	chr9	79853254	79853254	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacatctagcacagctcactGcagcaactttgacaaaactg	14	9	6	12	0	2	1	1	1	1	0	2	1	2	1	0	0	7	4	0	0	5	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:79853254G>T	uc004akr.2	+	19	2112	c.1852G>T	c.(1852-1854)GCA>TCA	p.A618S	VPS13A_uc004akp.3_Missense_Mutation_p.A618S|VPS13A_uc004akq.3_Missense_Mutation_p.A618S|VPS13A_uc004aks.2_Missense_Mutation_p.A618S	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	618					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						ACAGCTCACTGCAGCAACTTT	0.348													29	39					3.48256e-35	1.97699e-34	1	0	T	79853254	T	T	79853254	3	4	88	1	0	0	0	0	1	0	0	0	17257	1319	46	4	1926	4	VPS13A	9	79853254	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	5520263	79853254	61360177	65	17490											
KIAA1529	57653	broad.mit.edu	37	chr9	100090306	100090306	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctacctacctcccaggtatGaatgttttcacaccctcctg	8	12	5	16	0	1	1	1	1	0	0	3	1	3	1	6	1	2	2	6	1	4	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:100090306G>T	uc011lut.1	+	28	2988	c.2215G>T	c.(2215-2217)GAA>TAA	p.E739*	KIAA1529_uc004axe.1_Nonsense_Mutation_p.E739*|KIAA1529_uc004axg.1_Nonsense_Mutation_p.E600*|KIAA1529_uc004axh.1_5'Flank|KIAA1529_uc011luw.1_5'Flank|KIAA1529_uc011lus.1_Nonsense_Mutation_p.E557*|KIAA1529_uc010msm.1_Intron|KIAA1529_uc004axf.2_Nonsense_Mutation_p.E600*|KIAA1529_uc011luv.1_Nonsense_Mutation_p.E597*	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TCCCAGGTATGAATGTTTTCA	0.517													86	118					2.61895e-37	1.49585e-36	1	0	T	100090306	T	T	100090306	4	4	88	1	0	0	0	0	0	1	0	0	8279	1291	45	2	2289	2	KIAA1529	9	100090306	Nonsense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	20237052	100090306	41123125	66	17491											
ASTN2	23245	broad.mit.edu	37	chr9	119976967	119976967	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctgccaacgtcgctgggCgtacagcgccacggtgaaca	8	7	12	14	5	1	1	0	1	1	0	2	1	1	1	2	2	5	2	2	2	3	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:119976967C>T	uc004bjs.1	-	3	786	c.685G>A	c.(685-687)GCC>ACC	p.A229T	ASTN2_uc004bjr.1_Missense_Mutation_p.A229T|ASTN2_uc004bjt.1_Missense_Mutation_p.A229T	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	229	Cytoplasmic (Potential).		A -> V (found in a clear cell renal carcinoma case; somatic mutation).			integral to membrane		p.A229V(1)		skin(4)|ovary(3)|breast(1)|kidney(1)	9						CGTCGCTGGGCGTACAGCGCC	0.607													31	36					0	0	0	0	T	119976967	T	T	119976967	3	4	88	1	0	0	0	0	1	0	0	0	1067	768	27	1	3493	1	ASTN2	9	119976967	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	19886661	119976967	21236464	67	17492											
NAIF1	203245	broad.mit.edu	37	chr9	130829161	130829161	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggacctcggtcttgaggtCagaccacttcttcttgacct	7	12	9	13	2	4	3	1	2	3	1	5	4	4	4	3	3	0	0	3	3	0	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:130829161C>G	uc004bta.2	-	1	439	c.220G>C	c.(220-222)GAC>CAC	p.D74H	NAIF1_uc004bsz.2_RNA|SLC25A25_uc004btb.2_5'Flank	NM_197956	NP_931045	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	74					apoptosis|induction of apoptosis	nucleus					0						GTCTTGAGGTCAGACCACTTC	0.697													83	12					0	0	0	0	G	130829161	G	G	130829161	3	3	88	1	0	0	0	0	1	0	0	0	10199	826	29	2	771	2	NAIF1	9	130829161	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	10852194	130829161	10384270	68	17493											
MYO3A	53904	broad.mit.edu	37	chr10	26377179	26377179	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attttacaagtgaacaatttGgtagaagcctttggcaatgc	13	13	9	6	0	0	2	0	1	0	1	0	2	0	2	1	2	4	2	1	2	7	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:26377179G>T	uc001isn.2	+	15	1767	c.1407G>T	c.(1405-1407)TTG>TTT	p.L469F	MYO3A_uc009xko.1_Missense_Mutation_p.L469F|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.L469F	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	469	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TGAACAATTTGGTAGAAGCCT	0.294													15	21					3.45872e-05	0.000175004	1	0	T	26377179	T	T	26377179	3	4	88	1	0	0	0	0	1	0	0	0	10129	1339	47	4	1457	4	MYO3A	10	26377179	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08		26377179	109157568	69	17494											
CCAR1	55749	broad.mit.edu	37	chr10	70514524	70514524	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatatcataagtcatgtgcTcttgctgaggacccacaaga	12	12	8	9	0	3	2	2	1	1	1	3	3	3	3	1	1	2	2	1	1	4	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:70514524T>A	uc001joo.2	+	12	1517	c.1398T>A	c.(1396-1398)GCT>GCA	p.A466A	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Silent_p.A271A|CCAR1_uc009xpx.1_Silent_p.A440A|CCAR1_uc001jon.1_Silent_p.A412A|CCAR1_uc010qiz.1_Silent_p.A451A|CCAR1_uc010qja.1_Silent_p.A451A|CCAR1_uc010qjb.1_RNA|SNORD98_uc001jop.1_5'Flank	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	466					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						AGTCATGTGCTCTTGCTGAGG	0.358													32	44					0	0	0	0	A	70514524	A	A	70514524	2	1	88	1	0	0	0	0	0	0	0	1	2742	1538	54	5		5	CCAR1	10	70514524	Silent	SNP	T	TCGA-CN-6997-01A-11D-2012-08	44137345	70514524	65020223	70	17495											
DDX21	9188	broad.mit.edu	37	chr10	70728814	70728814	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttgccaagaaatacatgaaAtctacatatgaacaggtgga	17	9	9	6	0	1	3	0	2	1	1	1	4	1	4	1	2	4	1	1	2	7	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:70728814A>G	uc001jov.1	+	7	1263	c.1173A>G	c.(1171-1173)AAA>AAG	p.K391K	DDX21_uc001jow.1_Silent_p.K323K	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	391	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						AATACATGAAATCTACATATG	0.363													34	48					0	0	0	0	G	70728814	G	G	70728814	2	3	88	1	0	0	0	0	0	0	0	1	4366	98	4	5		5	DDX21	10	70728814	Silent	SNP	A	TCGA-CN-6997-01A-11D-2012-08	214290	70728814	64805933	71	17496											
SH3PXD2A	9644	broad.mit.edu	37	chr10	105362339	105362339	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccagctccccaaacctcacaTaccaccacccgctctcctgc	9	6	3	23	1	2	0	1	0	1	0	4	0	3	0	8	0	4	2	8	0	2	1			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:105362339T>A	uc001kxj.1	-	14	2692	c.2552A>T	c.(2551-2553)TAT>TTT	p.Y851F	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Missense_Mutation_p.Y686F|SH3PXD2A_uc010qqt.1_Missense_Mutation_p.Y728F|SH3PXD2A_uc009xxn.1_Missense_Mutation_p.Y686F|SH3PXD2A_uc010qqu.1_Missense_Mutation_p.Y794F	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	879	SH3 4.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		AAACCTCACATACCACCACCC	0.612													29	34					0	0	0	0	A	105362339	A	A	105362339	3	1	88	1	0	0	0	0	1	0	0	0	14321	1406	49	5	769	5	SH3PXD2A	10	105362339	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	34633525	105362339	30172408	72	17497											
GRK5	2869	broad.mit.edu	37	chr10	121207759	121207759	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agccgggatgttggaccctcCcttcgttccagacgtgagta	7	10	12	12	3	0	2	0	1	0	1	3	4	2	4	4	2	1	3	4	2	1	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:121207759C>T	uc001led.2	+	13	1624	c.1391C>T	c.(1390-1392)CCC>CTC	p.P464L	GRK5_uc009xzh.2_Missense_Mutation_p.P329L	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	464	AGC-kinase C-terminal.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		TTGGACCCTCCCTTCGTTCCA	0.627													70	100					0	0	0	0	T	121207759	T	T	121207759	3	4	88	1	0	0	0	0	1	0	0	0	6831	623	22	4	1441	4	GRK5	10	121207759	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	15845420	121207759	14326988	73	17498											
BAG3	9531	broad.mit.edu	37	chr10	121411327	121411327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccacaacagccgcaccaCtacgtggaacgacccgcgcg	11	2	11	17	6	0	0	0	0	0	0	0	3	0	2	4	2	4	1	4	2	3	1			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:121411327C>T	uc001lem.2	+	1	446	c.140C>T	c.(139-141)ACT>ATT	p.T47I	BAG3_uc001lel.2_Missense_Mutation_p.T47I	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	47	WW 1.				anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		AGCCGCACCACTACGTGGAAC	0.726													24	17					0	0	0	0	T	121411327	T	T	121411327	3	4	88	1	0	0	0	0	1	0	0	0	1290	565	20	4	142	4	BAG3	10	121411327	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	203568	121411327	14123420	74	17499											
CDHR5	53841	broad.mit.edu	37	chr11	621106	621106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccccgtggggacagcccCgtggtactgagcttgaatgc	6	8	15	12	2	0	2	0	2	0	0	0	3	0	3	4	3	5	2	4	3	2	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:621106C>T	uc001lqj.2	-	7	868	c.763G>A	c.(763-765)GGG>AGG	p.G255R	CDHR5_uc001lqk.2_Missense_Mutation_p.G255R|CDHR5_uc009ycc.2_Missense_Mutation_p.G89R|CDHR5_uc009ycd.2_Missense_Mutation_p.G255R|CDHR5_uc001lql.2_Missense_Mutation_p.G255R|CDHR5_uc001lqm.2_Missense_Mutation_p.G89R|CDHR5_uc009yce.1_Missense_Mutation_p.G224R	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	255	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						GGGACAGCCCCGTGGTACTGA	0.652													24	29					0	0	0	0	T	621106	T	T	621106	3	4	88	1	0	0	0	0	1	0	0	0	3137	652	23	1	1810	1	CDHR5	11	621106	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08		621106	134385410	75	17500											
MUC5B	727897	broad.mit.edu	37	chr11	1261156	1261156	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcaagggtccccacagcGgagaactgccagagctggtg	9	5	16	11	1	0	2	0	0	0	2	1	3	1	2	3	4	5	2	3	4	2	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:1261156G>A	uc009ycr.1	+	44	5916	c.5790G>A	c.(5788-5790)GCG>GCA	p.A1930A	MUC5B_uc001ltb.2_Silent_p.A1240A|MUC5B_uc001lta.2_Silent_p.A905A	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1237	Cys-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCCCACAGCGGAGAACTGCC	0.657													6	20					0	0	0	0	A	1261156	A	A	1261156	2	1	88	1	0	0	0	0	0	0	0	1	10032	1103	39	1		1	MUC5B	11	1261156	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08	640050	1261156	133745360	76	17501											
OR52A5	390054	broad.mit.edu	37	chr11	5153166	5153166	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattaaaggccttgaatcgtGcctccttctggggcagctga	8	12	11	10	1	1	2	0	2	1	0	3	2	2	2	3	3	2	2	3	3	4	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:5153166G>A	uc010qyx.1	-	1	707	c.707C>T	c.(706-708)GCA>GTA	p.A236V		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CTTGAATCGTGCCTCCTTCTG	0.408													14	35					0	0	0	0	A	5153166	A	A	5153166	3	1	88	1	0	0	0	0	1	0	0	0	11164	1319	46	4	246	4	OR52A5	11	5153166	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	3892010	5153166	129853350	77	17502											
NAV2	89797	broad.mit.edu	37	chr11	20126982	20126982	+	Translation_Start_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaatttgttgcattagcatAtacaccttctgtttctaacg	10	16	5	10	1	2	0	0	0	2	0	2	0	2	0	2	0	4	4	2	0	5	8			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:20126982A>G	uc001mpv.2	+	1	1226	c.-164A>G	c.(-166--162)ATATA>ATGTA		NAV2_uc001mpp.2_Intron|NAV2_uc001mpr.3_Intron|NAV2_uc009yhx.2_Intron|NAV2_uc009yhz.2_Intron|NAV2_uc001mpu.2_Intron			Q8IVL1	NAV2_HUMAN	Homo sapiens mRNA for KIAA1419 protein, partial cds.							nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GCATTAGCATATACACCTTCT	0.264													17	11					0	0	0	0	G	20126982	G	G	20126982	1	3	88	1	0	0	0	0	0	0	0	0	10237	464	16	5		5	NAV2	11	20126982	Translation_Start_Site	SNP	A	TCGA-CN-6997-01A-11D-2012-08	14973816	20126982	114879534	78	17503											
OR4C15	81309	broad.mit.edu	37	chr11	55322553	55322553	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atggtggtcatcaacagtggGtttatctgcatcataaactt	11	14	9	7	0	4	0	3	0	1	0	4	0	4	0	0	3	3	2	0	3	4	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:55322553G>T	uc010rig.1	+	1	771	c.771G>T	c.(769-771)GGG>GGT	p.G257G		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCAACAGTGGGTTTATCTGCA	0.463										HNSCC(20;0.049)			15	22					3.27435e-08	1.7126e-07	1	0	T	55322553	T	T	55322553	2	4	88	1	0	0	0	0	0	0	0	1	11102	1248	44	4		4	OR4C15	11	55322553	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08	35195571	55322553	79683963	79	17504											
OR4C6	219432	broad.mit.edu	37	chr11	55433051	55433051	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacgatcatcatgagtccaCgggtgtgctgcctaatggta	10	10	11	10	2	2	1	2	1	0	0	3	2	3	1	2	2	2	2	2	2	2	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:55433051C>T	uc001nht.3	+	3	674	c.409C>T	c.(409-411)CGG>TGG	p.R137W	OR4C6_uc010rik.1_Missense_Mutation_p.R137W	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CATGAGTCCACGGGTGTGCTG	0.512													48	18					0	0	0	0	T	55433051	T	T	55433051	3	4	88	1	0	0	0	0	1	0	0	0	11106	527	19	1	411	1	OR4C6	11	55433051	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	110498	55433051	79573465	80	17505											
KAT5	10524	broad.mit.edu	37	chr11	65482325	65482325	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacgacatcctccaggcaatGagatttaccgcaagggcacc	12	7	9	13	2	0	1	0	1	0	1	2	3	2	1	4	2	2	3	4	2	4	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:65482325G>A	uc001ofi.2	+	9	1124	c.874G>A	c.(874-876)GAG>AAG	p.E292K	KAT5_uc001ofj.2_Missense_Mutation_p.E240K|KAT5_uc001ofk.2_Missense_Mutation_p.E325K|KAT5_uc010roo.1_Missense_Mutation_p.E273K|KAT5_uc001ofl.2_Missense_Mutation_p.E81K	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	292					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						TCCAGGCAATGAGATTTACCG	0.537													36	99					0	0	0	0	A	65482325	A	A	65482325	3	1	88	1	0	0	0	0	1	0	0	0	8022	1291	45	2	1003	2	KAT5	11	65482325	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	10049274	65482325	69524191	81	17506											
ODZ4	26011	broad.mit.edu	37	chr11	78516412	78516412	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggaggaaggttccgtggcCtgaacactggtctaagcatg	9	8	15	9	2	1	1	0	1	1	0	2	3	2	3	2	5	2	2	2	5	3	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:78516412C>A	uc001ozl.3	-	15	2567	c.2104G>T	c.(2104-2106)GGC>TGC	p.G702C		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	702	Extracellular (Potential).|EGF-like 5.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GTTCCGTGGCCTGAACACTGG	0.607													6	3					8.12818e-05	0.000406846	1	0	A	78516412	A	A	78516412	3	1	88	1	0	0	0	0	1	0	0	0	10891	681	24	4	6285	4	ODZ4	11	78516412	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	13034087	78516412	56490104	82	17507											
NOX4	50507	broad.mit.edu	37	chr11	89070672	89070672	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgacatagtcaggtctgttCtcttgccaaaactgagagga	11	12	10	8	0	3	2	1	2	2	1	4	4	3	3	1	2	2	1	1	2	3	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:89070672C>T	uc001pct.2	-	16	1697	c.1458G>A	c.(1456-1458)GAG>GAA	p.E486E	NOX4_uc009yvr.2_Silent_p.E461E|NOX4_uc001pcu.2_Silent_p.E412E|NOX4_uc001pcw.2_Silent_p.E179E|NOX4_uc001pcx.2_Silent_p.E139E|NOX4_uc001pcv.2_Silent_p.E446E|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Silent_p.E299E|NOX4_uc009yvp.2_Silent_p.E250E|NOX4_uc010rtv.1_Silent_p.E422E|NOX4_uc009yvq.2_Silent_p.E462E	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	486	Cytoplasmic (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CAGGTCTGTTCTCTTGCCAAA	0.368													5	22					0	0	0	0	T	89070672	T	T	89070672	2	4	88	1	0	0	0	0	0	0	0	1	10612	912	32	2		2	NOX4	11	89070672	Silent	SNP	C	TCGA-CN-6997-01A-11D-2012-08	10554260	89070672	45935844	83	17508											
CNTN5	53942	broad.mit.edu	37	chr11	100169994	100169994	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaaaaatggtgacatcctCtgaagcttccaaattcattt	14	12	7	8	0	2	2	1	2	1	0	4	3	4	3	2	2	1	1	2	2	5	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:100169994C>T	uc001pga.2	+	20	2825	c.2486C>T	c.(2485-2487)TCT>TTT	p.S829F	CNTN5_uc001pfz.2_Missense_Mutation_p.S829F|CNTN5_uc001pgb.2_Missense_Mutation_p.S755F|CNTN5_uc010ruk.1_Missense_Mutation_p.S100F	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	829	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GTGACATCCTCTGAAGCTTCC	0.433													46	11					0	0	0	0	T	100169994	T	T	100169994	3	4	88	1	0	0	0	0	1	0	0	0	3659	913	32	2	2556	2	CNTN5	11	100169994	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	11099322	100169994	34836522	84	17509											
EXPH5	23086	broad.mit.edu	37	chr11	108380450	108380450	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gactctgaggggttgggaggGttcctcaaatcatcttttag	8	13	13	7	0	4	1	2	1	2	0	5	3	5	2	1	4	0	2	1	4	2	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:108380450G>A	uc001pkk.2	-	6	5895	c.5784C>T	c.(5782-5784)AAC>AAT	p.N1928N	EXPH5_uc010rvy.1_Silent_p.N1740N|EXPH5_uc010rvz.1_Silent_p.N1772N|EXPH5_uc010rwa.1_Silent_p.N1852N	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1928					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GGTTGGGAGGGTTCCTCAAAT	0.413													50	13					0	0	0	0	A	108380450	A	A	108380450	2	1	88	1	0	0	0	0	0	0	0	1	5347	1252	44	4		4	EXPH5	11	108380450	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08	8210456	108380450	26626066	85	17510											
UBE4A	9354	broad.mit.edu	37	chr11	118263519	118263519	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctgtgatgagttcctggatCccattatgagcacactgatg	9	12	10	10	0	0	4	0	4	0	0	2	5	2	5	3	1	1	2	3	1	1	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:118263519C>T	uc001psw.2	+	19	3112	c.2983C>T	c.(2983-2985)CCC>TCC	p.P995S	UBE4A_uc001psv.2_Missense_Mutation_p.P1002S	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	995	U-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GTTCCTGGATCCCATTATGAG	0.473													131	26					0	0	0	0	T	118263519	T	T	118263519	3	4	88	1	0	0	0	0	1	0	0	0	16950	855	30	2	3074	2	UBE4A	11	118263519	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	9883069	118263519	16742997	86	17511											
TECTA	7007	broad.mit.edu	37	chr11	121058640	121058640	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttaaattcataggggattaCgacgaagttcaccttcactg	12	13	8	8	2	3	0	3	0	0	0	3	3	3	1	1	2	1	1	1	2	5	7			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:121058640C>T	uc010rzo.1	+	20	6099	c.6099C>T	c.(6097-6099)TAC>TAT	p.Y2033Y		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	2033	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TAGGGGATTACGACGAAGTTC	0.453													72	15					0	0	0	0	T	121058640	T	T	121058640	2	4	88	1	0	0	0	0	0	0	0	1	15813	547	19	1		1	TECTA	11	121058640	Silent	SNP	C	TCGA-CN-6997-01A-11D-2012-08	2795121	121058640	13947876	87	17512											
KCNJ1	3758	broad.mit.edu	37	chr11	128709211	128709211	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccttcctttgtcttggataCtatgggagcaaaacggtagc	9	12	10	10	1	1	0	0	0	1	0	2	2	2	2	2	3	4	2	2	3	5	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:128709211C>G	uc001qeo.1	-	2	1036	c.985G>C	c.(985-987)GTA>CTA	p.V329L	KCNJ1_uc001qep.1_Missense_Mutation_p.V310L|KCNJ1_uc001qeq.1_Missense_Mutation_p.V310L|KCNJ1_uc001qer.1_Missense_Mutation_p.V310L|KCNJ1_uc001qes.1_Missense_Mutation_p.V310L	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	329	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	GTCTTGGATACTATGGGAGCA	0.493													44	37					0	0	0	0	G	128709211	G	G	128709211	3	3	88	1	0	0	0	0	1	0	0	0	8082	565	20	4	194	4	KCNJ1	11	128709211	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	7650571	128709211	6297305	88	17513											
TNFRSF1A	7132	broad.mit.edu	37	chr12	6438514	6438514	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcgcgggcgggagggcggcGgggccgcaaagcgcctcctc	4	2	21	14	7	0	0	0	0	0	0	2	1	1	1	3	7	1	1	3	7	1	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:6438514G>A	uc001qnu.2	-	10	1613	c.1332C>T	c.(1330-1332)CCC>CCT	p.P444P	TNFRSF1A_uc001qnt.2_Silent_p.P336P|TNFRSF1A_uc010sey.1_Silent_p.P212P|TNFRSF1A_uc010sez.1_Silent_p.P336P|TNFRSF1A_uc009zek.2_Silent_p.P401P	NM_001065	NP_001056	P19438	TNR1A_HUMAN	tumor necrosis factor receptor 1 precursor	444	Cytoplasmic (Potential).			GPAA -> APP (in Ref. 5; AAA36756).	apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			lung(2)|skin(1)	3						ggagggcggcggggccgcAAA	0.567													6	18					0	0	0	0	A	6438514	A	A	6438514	2	1	88	1	0	0	0	0	0	0	0	1	16359	1103	39	1		1	TNFRSF1A	12	6438514	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08		6438514	127413381	89	17514											
LRP6	4040	broad.mit.edu	37	chr12	12278294	12278294	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atgctcctgtaacatgggctCggtcataggggggtccactg	7	10	14	10	1	1	0	1	0	0	0	4	0	3	0	2	5	2	3	2	5	2	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:12278294C>G	uc001rah.3	-	21	4527	c.4385G>C	c.(4384-4386)CGA>CCA	p.R1462P	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.R1417P	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1462	Cytoplasmic (Potential).				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				AACATGGGCTCGGTCATAGGG	0.443													18	22					0	0	0	0	G	12278294	G	G	12278294	3	3	88	1	0	0	0	0	1	0	0	0	9012	884	31	3	468	3	LRP6	12	12278294	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	5839780	12278294	121573601	90	17515											
BCAT1	586	broad.mit.edu	37	chr12	25047338	25047338	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatgatccgtgaacacagtTccaaaaaccagattattggg	15	10	8	8	1	0	3	0	2	0	1	2	3	2	3	3	1	2	1	3	1	5	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:25047338T>G	uc001rgd.3	-	3	592	c.150A>C	c.(148-150)GGA>GGC	p.G50G	BCAT1_uc001rgc.2_Silent_p.G49G|BCAT1_uc010six.1_Silent_p.G62G|BCAT1_uc010siy.1_Silent_p.G50G|BCAT1_uc001rge.3_Silent_p.G26G	NM_005504	NP_005495	P54687	BCAT1_HUMAN	branched chain aminotransferase 1, cytosolic	50					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			lung(1)|breast(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	TGAACACAGTTCCAAAAACCA	0.438													5	15					0	0	0	0	G	25047338	G	G	25047338	2	3	88	1	0	0	0	0	0	0	0	1	1356	1770	62	5		5	BCAT1	12	25047338	Silent	SNP	T	TCGA-CN-6997-01A-11D-2012-08	12769044	25047338	108804557	91	17516											
ITPR2	3709	broad.mit.edu	37	chr12	26781079	26781079	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagatcctataatccagtCtgacactcaggataaactat	15	11	6	9	0	2	2	1	2	1	1	4	4	4	3	2	1	1	0	2	1	5	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:26781079C>T	uc001rhg.2	-	23	3368	c.2951G>A	c.(2950-2952)AGA>AAA	p.R984K		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	984	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	p.R984K(1)		kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					ATAATCCAGTCTGACACTCAG	0.353													61	119					0	0	0	0	T	26781079	T	T	26781079	3	4	88	1	0	0	0	0	1	0	0	0	7960	913	32	2	5294	2	ITPR2	12	26781079	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	1733741	26781079	107070816	92	17517											
C12orf71	728858	broad.mit.edu	37	chr12	27234247	27234247	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctcagcagagaggggaggaTacgctgcctcagccagctga	10	5	14	12	1	2	2	2	1	0	1	2	5	2	4	3	3	5	3	3	3	1	1			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:27234247T>C	uc001rhq.2	-	2	709	c.670A>G	c.(670-672)ATC>GTC	p.I224V		NM_001080406	NP_001073875	A8MTZ7	CL071_HUMAN	hypothetical protein LOC728858	224											0						GAGGGGAGGATACGCTGCCTC	0.552													53	73					0	0	0	0	C	27234247	C	C	27234247	3	2	88	1	0	0	0	0	1	0	0	0	1718	1406	49	5	143	5	C12orf71	12	27234247	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	453168	27234247	106617648	93	17518											
MLL2	8085	broad.mit.edu	37	chr12	49420108	49420108	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcggaggctccaatagatgCgcgtggcctcgtagcccacg	7	7	14	13	5	0	1	0	0	0	1	2	2	1	2	3	3	3	2	3	3	3	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:49420108C>T	uc001rta.3	-	48	15641	c.15641G>A	c.(15640-15642)CGC>CAC	p.R5214H		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5214	FYR N-terminal.		R -> H (in KABS).		chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCAATAGATGCGCGTGGCCTC	0.577			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			23	30					0	0	0	0	T	49420108	T	T	49420108	3	4	88	1	0	0	0	0	1	0	0	0	9674	768	27	1	1000	1	MLL2	12	49420108	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	22185861	49420108	84431787	94	17519											
KRT78	196374	broad.mit.edu	37	chr12	53237950	53237950	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgagagatctggactttcGtttcctgcatcctgtcccca	6	13	9	13	1	1	2	0	1	1	1	5	4	4	3	4	1	1	3	4	1	0	2	rs145166082		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:53237950G>A	uc001sbc.1	-	6	1038	c.974C>T	c.(973-975)ACG>ATG	p.T325M		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	325	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						CTGGACTTTCGTTTCCTGCAT	0.527													81	96					0	0	0	0	A	53237950	A	A	53237950	3	1	88	1	0	0	0	0	1	0	0	0	8530	1145	40	1	604	1	KRT78	12	53237950	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	3817842	53237950	80613945	95	17520											
MAP3K12	7786	broad.mit.edu	37	chr12	53875912	53875913	+	Frame_Shift_Ins	INS	-	T	T																															gccactgggggaaggttcacINStagctgtgccttcctcccca																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:53875912_53875913insT	uc001sdm.1	-	14	2391_2392	c.2293_2294insA	c.(2293-2295)AGTfs	p.S765fs	MAP3K12_uc001sdn.1_Frame_Shift_Ins_p.S798fs	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	765					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						GGAAGGTTCACTAGCTGTGCCT	0.554											OREG0021873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								T	53875913	T	T	53875912	7	5	88	1	0	1	1	0	0	0	0	0	9299	565	20	0	293	0	MAP3K12	12	53875912	Frame_Shift_Ins	INS	-	TCGA-CN-6997-01A-11D-2012-08	637962	53875912	79975983	96	17521											
LRP1	4035	broad.mit.edu	37	chr12	57604642	57604642	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgatgcctacccggcttccTgggcgaccgctgccagtacc	5	7	11	18	4	0	0	0	0	0	0	1	2	1	0	7	2	4	3	7	2	2	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:57604642T>C	uc001snd.2	+	83	13362	c.12896T>C	c.(12895-12897)CTG>CCG	p.L4299P		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4299	Extracellular (Potential).|EGF-like 19.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCGGCTTCCTGGGCGACCGC	0.647													3	36					0	0	0	0	C	57604642	C	C	57604642	3	2	88	1	0	0	0	0	1	0	0	0	9001	1580	55	5	13226	5	LRP1	12	57604642	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	3728730	57604642	76247253	97	17522											
B4GALNT1	2583	broad.mit.edu	37	chr12	58021951	58021951	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtccacaagcctctccagcCgcgtccgcgccgtgaagacg	7	5	11	18	7	1	2	0	1	1	1	4	2	3	2	6	0	2	0	6	0	2	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:58021951C>T	uc001spg.1	-	9	1529	c.1097G>A	c.(1096-1098)CGG>CAG	p.R366Q	B4GALNT1_uc010sru.1_Missense_Mutation_p.R311Q	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	366	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CCTCTCCAGCCGCGTCCGCGC	0.652													24	39					0	0	0	0	T	58021951	T	T	58021951	3	4	88	1	0	0	0	0	1	0	0	0	1268	652	23	1	516	1	B4GALNT1	12	58021951	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	417309	58021951	75829944	98	17523											
ZFC3H1	196441	broad.mit.edu	37	chr12	72038823	72038823	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccaaaaggcgaagctgtaaTtcagatagttcctcttcatc	12	11	8	10	1	3	1	2	0	1	1	5	2	4	1	2	1	1	3	2	1	5	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:72038823T>A	uc001swo.2	-	4	1472	c.1113A>T	c.(1111-1113)GAA>GAT	p.E371D		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	371	Potential.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GAAGCTGTAATTCAGATAGTT	0.338													16	22					0	0	0	0	A	72038823	A	A	72038823	3	1	88	1	0	0	0	0	1	0	0	0	17700	1490	52	5	4984	5	ZFC3H1	12	72038823	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	14016872	72038823	61813072	99	17524											
NAV3	89795	broad.mit.edu	37	chr12	78400648	78400648	+	Frame_Shift_Del	DEL	C	-	-																															atagcagtcccaaagtgtcaCctaagttggcccctccaaaa																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:78400648delC	uc001syp.2	+	8	1503	c.1330delC	c.(1330-1332)CCTfs	p.P444fs	NAV3_uc001syo.2_Frame_Shift_Del_p.P444fs	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	444						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CAAAGTGTCACCTAAGTTGGC	0.408										HNSCC(70;0.22)			---	---	---								-	78400648	-	-	78400648	7	5	88	1	0	1	0	1	0	0	0	0	10238	507	18	0	1360	0	NAV3	12	78400648	Frame_Shift_Del	DEL	C	TCGA-CN-6997-01A-11D-2012-08	6361825	78400648	55451247	100	17525											
DDX55	57696	broad.mit.edu	37	chr12	124104018	124104018	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcgaggttttgccctgcTgaggatgcccaagatgccag	7	10	13	11	1	0	2	0	1	0	1	1	4	0	3	3	2	5	3	3	2	1	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:124104018T>C	uc001ufi.2	+	13	1397	c.1373T>C	c.(1372-1374)CTG>CCG	p.L458P	DDX55_uc001ufh.2_Nonstop_Mutation_p.*306R|DDX55_uc001ufk.2_Missense_Mutation_p.L311P|DDX55_uc001ufl.2_Missense_Mutation_p.L65P	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	458							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TTTGCCCTGCTGAGGATGCCC	0.438													49	79					0	0	0	0	C	124104018	C	C	124104018	3	2	88	1	0	0	0	0	1	0	0	0	4390	1580	55	5	1423	5	DDX55	12	124104018	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	45703370	124104018	9747877	101	17526											
GOLGA3	2802	broad.mit.edu	37	chr12	133384625	133384625	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatctcctggccgttgaccaTatagggggtgtcctgcgtgc	6	11	13	11	2	1	1	0	1	1	0	3	1	2	1	4	3	2	1	4	3	3	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:133384625T>C	uc001ukz.1	-	5	1589	c.1030A>G	c.(1030-1032)ATG>GTG	p.M344V	GOLGA3_uc001ula.1_Missense_Mutation_p.M344V|GOLGA3_uc001ulb.2_Missense_Mutation_p.M344V	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	344					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CCGTTGACCATATAGGGGGTG	0.612													33	38					0	0	0	0	C	133384625	C	C	133384625	3	2	88	1	0	0	0	0	1	0	0	0	6591	1406	49	5	3684	5	GOLGA3	12	133384625	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	9280607	133384625	467270	102	17527											
SACS	26278	broad.mit.edu	37	chr13	23905802	23905802	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgcttcaaaaaagcaaaagtTtcacttctgctgtggggaat	13	11	9	8	1	3	0	2	0	1	0	3	1	3	1	0	2	2	4	0	2	6	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:23905802T>C	uc001uon.2	-	10	12802	c.12213A>G	c.(12211-12213)GAA>GAG	p.E4071E	SACS_uc001uoo.2_Silent_p.E3924E|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4071					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAGCAAAAGTTTCACTTCTGC	0.363													19	33					0	0	0	0	C	23905802	C	C	23905802	2	2	88	1	0	0	0	0	0	0	0	1	13869	1838	64	5		5	SACS	13	23905802	Silent	SNP	T	TCGA-CN-6997-01A-11D-2012-08		23905802	91264076	103	17528											
CDK8	1024	broad.mit.edu	37	chr13	26967609	26967609	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatccttatcaccatgaccAgctggacagaatattcaatg	14	11	6	10	0	2	2	2	1	0	1	3	3	3	3	3	1	1	1	3	1	5	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:26967609A>G	uc001uqr.1	+	7	778	c.752A>G	c.(751-753)CAG>CGG	p.Q251R	CDK8_uc001uqs.1_Missense_Mutation_p.Q251R|CDK8_uc001uqt.1_Missense_Mutation_p.Q78R	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	251	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		CACCATGACCAGCTGGACAGA	0.363													73	109					0	0	0	0	G	26967609	G	G	26967609	3	3	88	1	0	0	0	0	1	0	0	0	3165	188	7	5	778	5	CDK8	13	26967609	Missense_Mutation	SNP	A	TCGA-CN-6997-01A-11D-2012-08	3061807	26967609	88202269	104	17529											
FLT1	2321	broad.mit.edu	37	chr13	28913349	28913349	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actcccacttgctggcatcaTaagggagccgctcacactgc	9	8	9	15	1	2	0	2	0	0	0	3	1	3	1	2	2	3	3	2	2	1	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:28913349T>C	uc001usb.3	-	17	2729	c.2444A>G	c.(2443-2445)TAT>TGT	p.Y815C	FLT1_uc001usa.3_Missense_Mutation_p.Y33C	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	815	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GCTGGCATCATAAGGGAGCCG	0.348													21	38					0	0	0	0	C	28913349	C	C	28913349	3	2	88	1	0	0	0	0	1	0	0	0	5973	1406	49	5	1628	5	FLT1	13	28913349	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	1945740	28913349	86256529	105	17530											
FRY	10129	broad.mit.edu	37	chr13	32798394	32798394	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatccaatttctccctacacGggctggttgctgactattac	8	13	8	12	1	1	1	0	1	1	0	3	2	2	1	2	2	3	3	2	2	4	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:32798394G>A	uc001utx.2	+	37	5284	c.4788G>A	c.(4786-4788)ACG>ACA	p.T1596T	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1596					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTCCCTACACGGGCTGGTTGC	0.498													42	48					0	0	0	0	A	32798394	A	A	32798394	2	1	88	1	0	0	0	0	0	0	0	1	6097	1103	39	1		1	FRY	13	32798394	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08	3885045	32798394	82371484	106	17531											
ZC3H13	23091	broad.mit.edu	37	chr13	46577305	46577305	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcttttctctttgtcgttCaaaatctcgtcctctgtcct	4	20	4	13	2	5	0	1	0	4	0	11	0	7	0	2	0	0	1	2	0	2	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:46577305C>G	uc010tfw.1	-	7	919	c.913G>C	c.(913-915)GAA>CAA	p.E305Q	ZC3H13_uc001vas.1_Missense_Mutation_p.E305Q|ZC3H13_uc001vat.1_Missense_Mutation_p.E305Q	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	305							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		CTTTGTCGTTCAAAATCTCGT	0.313													7	154					0	0	0	0	G	46577305	G	G	46577305	3	3	88	1	0	0	0	0	1	0	0	0	17632	835	29	2	3821	2	ZC3H13	13	46577305	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	13778911	46577305	68592573	107	17532											
GPC5	2262	broad.mit.edu	37	chr13	92408604	92408604	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctatggaggtctagctgatCagctttgtgctaatgaatta	10	15	10	6	0	3	2	1	2	2	0	3	3	3	3	0	2	3	3	0	2	5	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:92408604C>T	uc010tif.1	+	5	1576	c.1210C>T	c.(1210-1212)CAG>TAG	p.Q404*		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	404						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TCTAGCTGATCAGCTTTGTGC	0.373													27	62					0	0	0	0	T	92408604	T	T	92408604	4	4	88	1	0	0	0	0	0	1	0	0	6639	827	29	2	1228	2	GPC5	13	92408604	Nonsense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	45831299	92408604	22761274	108	17533											
COL4A1	1282	broad.mit.edu	37	chr13	110831315	110831315	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagggggacccctagctcCaggggggcctattcctggaa	7	7	14	13	0	0	0	0	0	0	0	3	2	3	2	6	6	1	1	6	6	3	3	rs113994110		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:110831315C>T	uc001vqw.3	-	31	2535	c.2413G>A	c.(2413-2415)GGA>AGA	p.G805R	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	805	Triple-helical region.		G -> R (in BSVDH).		angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCCCTAGCTCCAGGGGGGCCT	0.547													6	16					0	0	0	0	T	110831315	T	T	110831315	3	4	88	1	0	0	0	0	1	0	0	0	3704	603	21	4	2684	4	COL4A1	13	110831315	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	18422711	110831315	4338563	109	17534											
JUB	84962	broad.mit.edu	37	chr14	23451332	23451332	+	Frame_Shift_Del	DEL	C	-	-																															cccccagtagctcctcggggCcctgacttcctaggtccccc																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr14:23451332delC	uc001whz.2	-	1	520	c.144delG	c.(142-144)GGGfs	p.G48fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	48	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CTCCTCGGGGCCCTGACTTCC	0.682													---	---	---								-	23451332	-	-	23451332	7	5	88	1	0	1	0	1	0	0	0	0	8007	726	26	0	1504	0	JUB	14	23451332	Frame_Shift_Del	DEL	C	TCGA-CN-6997-01A-11D-2012-08		23451332	83898208	110	17535											
NIN	51199	broad.mit.edu	37	chr14	51227017	51227017	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatgcctttgcttcatgtTctcctgtgccttcttgcagc	3	17	7	14	0	4	0	2	0	2	0	5	0	4	0	3	0	5	3	3	0	0	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr14:51227017T>A	uc001wym.2	-	17	2148	c.1957A>T	c.(1957-1959)AAC>TAC	p.N653Y	NIN_uc001wyi.2_Missense_Mutation_p.N653Y|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.N653Y|NIN_uc010tqp.1_Missense_Mutation_p.N659Y|NIN_uc001wyo.2_Missense_Mutation_p.N653Y	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	653	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TGCTTCATGTTCTCCTGTGCC	0.468			T	PDGFRB	MPD								82	25					0	0	0	0	A	51227017	A	A	51227017	3	1	88	1	0	0	0	0	1	0	0	0	10471	1783	62	5	4652	5	NIN	14	51227017	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	27775685	51227017	56122523	111	17536											
PARP6	56965	broad.mit.edu	37	chr15	72534499	72534499	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatgggcaagctacctaccTtcacaaagtgctatacagtt	13	10	7	11	0	1	0	1	0	0	0	1	0	1	0	2	1	5	4	2	1	6	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr15:72534499T>C	uc002auc.2	-	21	2163	c.1704A>G	c.(1702-1704)GAA>GAG	p.E568E	PARP6_uc002aua.2_Silent_p.E414E|PARP6_uc002aub.2_RNA|PARP6_uc002aud.3_RNA|PARP6_uc002auf.1_Silent_p.E569E	NM_020214	NP_064599	Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	568	PARP catalytic.						NAD+ ADP-ribosyltransferase activity				0						GCTACCTACCTTCACAAAGTG	0.473													15	9					0	0	0	0	C	72534499	C	C	72534499	2	2	88	1	0	0	0	0	0	0	0	1	11518	1623	56	5		5	PARP6	15	72534499	Silent	SNP	T	TCGA-CN-6997-01A-11D-2012-08		72534499	29996893	112	17537											
PRKCB	5579	broad.mit.edu	37	chr16	24196444	24196444	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttctagataattgcttatCagccctatgggaagtccgtg	9	15	9	8	1	2	1	1	0	1	1	3	2	3	2	2	1	2	1	2	1	5	7			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:24196444C>T	uc002dmd.2	+	14	1743	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	PRKCB_uc002dme.2_Nonsense_Mutation_p.Q516*	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	516	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	AATTGCTTATCAGCCCTATGG	0.433													5	84					0	0	0	0	T	24196444	T	T	24196444	4	4	88	1	0	0	0	0	0	1	0	0	12570	827	29	2	1600	2	PRKCB	16	24196444	Nonsense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08		24196444	66158309	113	17538											
RBBP6	5930	broad.mit.edu	37	chr16	24580072	24580072	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttttgtttttaggtctaaAtctccctatagtggttcttc	6	21	7	7	0	3	0	0	0	3	0	5	0	3	0	1	2	0	3	1	2	5	10			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:24580072A>G	uc002dmh.2	+	17	3101	c.2061A>G	c.(2059-2061)AAA>AAG	p.K687K	RBBP6_uc010vcb.1_Silent_p.K554K|RBBP6_uc002dmi.2_Silent_p.K653K|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Silent_p.K520K	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	687					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TTAGGTCTAAATCTCCCTATA	0.343													17	37					0	0	0	0	G	24580072	G	G	24580072	2	3	88	1	0	0	0	0	0	0	0	1	13168	98	4	5		5	RBBP6	16	24580072	Silent	SNP	A	TCGA-CN-6997-01A-11D-2012-08	383628	24580072	65774681	114	17539											
SALL1	6299	broad.mit.edu	37	chr16	51171062	51171062	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgctgtcctccacgaagcgGgtgaagcggaagttggttcc	7	10	14	10	3	0	1	0	1	0	0	3	3	3	2	3	3	3	3	3	3	3	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:51171062G>C	uc010vgs.1	-	3	3967	c.3936C>G	c.(3934-3936)ACC>ACG	p.T1312T	SALL1_uc010vgr.1_Silent_p.T1215T|SALL1_uc010cbv.2_Silent_p.T164T	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1312					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCACGAAGCGGGTGAAGCGGA	0.567													23	33					0	0	0	0	C	51171062	C	C	51171062	2	2	88	1	0	0	0	0	0	0	0	1	13875	1219	43	4		4	SALL1	16	51171062	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08	26590990	51171062	39183691	115	17540											
SALL1	6299	broad.mit.edu	37	chr16	51174418	51174418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgggggctggctcttccGtcttgatgaagggtatgagg	6	11	18	6	1	2	3	0	3	2	0	3	4	3	4	1	6	0	3	1	6	2	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:51174418G>A	uc010vgs.1	-	2	1746	c.1715C>T	c.(1714-1716)ACG>ATG	p.T572M	SALL1_uc010vgr.1_Missense_Mutation_p.T475M|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	572					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGCTCTTCCGTCTTGATGAA	0.602													17	31					0	0	0	0	A	51174418	A	A	51174418	3	1	88	1	0	0	0	0	1	0	0	0	13875	1145	40	1	2267	1	SALL1	16	51174418	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	3356	51174418	39180335	116	17541											
RLTPR	146206	broad.mit.edu	37	chr16	67682065	67682065	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgtggggggatggatgacCggcagggcggactggagggc	6	5	22	8	3	0	1	0	1	0	0	1	5	1	5	2	9	0	1	2	9	0	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:67682065C>A	uc002etn.2	+	14	1302	c.1182C>A	c.(1180-1182)ACC>ACA	p.T394T	RLTPR_uc010cel.1_Silent_p.T394T|RLTPR_uc010vjr.1_Intron	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	394	LRR 7.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GATGGATGACCGGCAGGGCGG	0.687													10	11					3.07112e-06	1.58845e-05	1	0	A	67682065	A	A	67682065	2	1	88	1	0	0	0	0	0	0	0	1	13459	639	23	3		3	RLTPR	16	67682065	Silent	SNP	C	TCGA-CN-6997-01A-11D-2012-08	16507647	67682065	22672688	117	17542											
SLC7A6OS	84138	broad.mit.edu	37	chr16	68336300	68336300	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacctctggaatcctcatcTccatcactgctctcctcctc	6	12	3	20	0	5	0	2	0	3	0	10	1	7	1	6	1	1	1	6	1	1	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:68336300T>C	uc002evw.1	-	4	802	c.783A>G	c.(781-783)GGA>GGG	p.G261G		NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	261					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		AATCCTCATCTCCATCACTGC	0.517													80	100					0	0	0	0	C	68336300	C	C	68336300	2	2	88	1	0	0	0	0	0	0	0	1	14766	1538	54	5		5	SLC7A6OS	16	68336300	Silent	SNP	T	TCGA-CN-6997-01A-11D-2012-08	654235	68336300	22018453	118	17543											
KIAA0182	23199	broad.mit.edu	37	chr16	85687968	85687969	+	Missense_Mutation	DNP	GC	TT	TT																															aggagaaggcagggggaccaGccatcccctcgcacctgctc																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:85687968_85687969GC>TT	uc002fix.2	+	4	585_586	c.511_512GC>TT	c.(511-513)GCC>TTC	p.A171F	KIAA0182_uc002fiw.2_Missense_Mutation_p.A67F|KIAA0182_uc002fiy.2_Missense_Mutation_p.A98F	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	171							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						AGGGGGACCAGCCATCCCCTCG	0.668													8	17					0	0	0	0	TT	85687969	TT	TT	85687968	3	4	88	1	0	0	0	0	1	0	0	0	8198	971	34	4	525	4	KIAA0182	16	85687968	Missense_Mutation	DNP	GC	TCGA-CN-6997-01A-11D-2012-08	17351668	85687968	4666785	119	17544											
POLR2A	5430	broad.mit.edu	37	chr17	7404147	7404147	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtggcccttacaagcacAtctctcctggggacaccaag	11	7	9	14	0	1	0	0	0	1	0	3	1	2	1	3	3	2	1	3	3	3	1			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:7404147A>G	uc002ghf.3	+	11	2095	c.1861A>G	c.(1861-1863)ATC>GTC	p.I621V		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	621					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				TTACAAGCACATCTCTCCTGG	0.527													31	87					0	0	0	0	G	7404147	G	G	7404147	3	3	88	1	0	0	0	0	1	0	0	0	12269	217	8	5	1903	5	POLR2A	17	7404147	Missense_Mutation	SNP	A	TCGA-CN-6997-01A-11D-2012-08		7404147	73791063	120	17545											
TP53	7157	broad.mit.edu	37	chr17	7578524	7578524	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggcaggtcttggccagttGgcaaaacatcttgttgaggg	9	10	15	7	0	2	1	0	1	2	0	2	1	2	1	1	5	1	4	1	5	2	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:7578524G>A	uc002gim.2	-	5	600	c.406C>T	c.(406-408)CAA>TAA	p.Q136*	TP53_uc002gig.1_Nonsense_Mutation_p.Q136*|TP53_uc002gih.2_Nonsense_Mutation_p.Q136*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q4*|TP53_uc010cng.1_Nonsense_Mutation_p.Q4*|TP53_uc002gii.1_Nonsense_Mutation_p.Q4*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q136*|TP53_uc010cni.1_Nonsense_Mutation_p.Q136*|TP53_uc002gij.2_Nonsense_Mutation_p.Q136*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.Q43*|TP53_uc002gio.2_Nonsense_Mutation_p.Q4*|TP53_uc010vug.1_Nonsense_Mutation_p.Q97*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	136	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q136*(28)|p.0?(7)|p.Q136H(5)|p.Q136Q(4)|p.Q136P(3)|p.Q136E(3)|p.N131fs*27(2)|p.Q136fs*13(2)|p.Q136R(2)|p.Q136fs*34(2)|p.V73fs*9(1)|p.F134_T140>S(1)|p.C135_T140delCQLAKT(1)|p.Q136K(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.Q136_K139delQLAK(1)|p.C135_Q136insX(1)|p.C135_Q136insXXXXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGCCAGTTGGCAAAACATC	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			64	7					0	0	0	0	A	7578524	A	A	7578524	4	1	88	1	0	0	0	0	0	1	0	0	16448	1357	47	4	892	4	TP53	17	7578524	Nonsense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	174377	7578524	73616686	121	17546											
MYH4	4622	broad.mit.edu	37	chr17	10364246	10364246	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtaccttccgtgccatcTggctctgcctgctcttccct	2	14	9	16	1	3	0	0	0	3	0	5	0	5	0	5	2	4	3	5	2	1	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:10364246T>A	uc002gmn.2	-	12	1245	c.1134A>T	c.(1132-1134)CCA>CCT	p.P378P	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	378	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CCGTGCCATCTGGCTCTGCCT	0.478													30	69					0	0	0	0	A	10364246	A	A	10364246	2	1	88	1	0	0	0	0	0	0	0	1	10090	1567	55	5		5	MYH4	17	10364246	Silent	SNP	T	TCGA-CN-6997-01A-11D-2012-08	2785722	10364246	70830964	122	17547											
USP22	23326	broad.mit.edu	37	chr17	20911270	20911270	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctatggcaaccgctgcacttGatcttggcgctgctgcccaa	7	10	10	14	2	1	1	0	1	1	0	1	1	1	1	2	2	4	5	2	2	3	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:20911270G>C	uc002gym.3	-	9	1347	c.1143C>G	c.(1141-1143)ATC>ATG	p.I381M	USP22_uc002gyn.3_Missense_Mutation_p.I369M|USP22_uc002gyl.3_Missense_Mutation_p.I276M	NM_015276	NP_056091	Q9UPT9	UBP22_HUMAN	ubiquitin thiolesterase 22	381					cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1						CGCTGCACTTGATCTTGGCGC	0.488													33	33					0	0	0	0	C	20911270	C	C	20911270	3	2	88	1	0	0	0	0	1	0	0	0	17122	1280	45	2	454	2	USP22	17	20911270	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	10547024	20911270	60283940	123	17548											
CCL1	6346	broad.mit.edu	37	chr17	32688843	32688843	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agatggagctggtatttctgTaacacaggattgccctcagg	10	11	12	8	0	2	1	1	0	1	1	2	3	2	3	1	4	3	3	1	4	2	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:32688843T>G	uc002hid.1	-	2	221	c.149A>C	c.(148-150)TAC>TCC	p.Y50S		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	50					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		GGTATTTCTGTAACACAGGAT	0.493											OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	110					0	0	0	0	G	32688843	G	G	32688843	3	3	88	1	0	0	0	0	1	0	0	0	2895	1638	57	5	149	5	CCL1	17	32688843	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	11777573	32688843	48506367	124	17549											
TMEM132E	124842	broad.mit.edu	37	chr17	32953362	32953362	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtcctcaacgtctctctggGgcccttcagcaccagccagg	6	8	11	16	1	4	0	2	0	2	0	6	0	5	0	4	4	3	1	4	4	1	1			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:32953362G>A	uc002hif.2	+	2	612	c.284G>A	c.(283-285)GGG>GAG	p.G95E		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	95	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GTCTCTCTGGGGCCCTTCAGC	0.697													8	24					0	0	0	0	A	32953362	A	A	32953362	3	1	88	1	0	0	0	0	1	0	0	0	16114	1232	43	4	290	4	TMEM132E	17	32953362	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	264519	32953362	48241848	125	17550											
PGAP3	93210	broad.mit.edu	37	chr17	37842182	37842182	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctccaactcaccttgccaTggaactgaggcactttgtga	9	10	8	14	0	1	2	1	2	0	0	2	3	2	3	4	2	3	1	4	2	2	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:37842182T>A	uc002hsj.2	-	2	315	c.272A>T	c.(271-273)CAT>CTT	p.H91L	ERBB2_uc002hsm.2_5'Flank|ERBB2_uc010cwa.2_5'Flank|PGAP3_uc010cvy.2_5'Flank|PGAP3_uc010wej.1_Missense_Mutation_p.H91L|PGAP3_uc002hsk.2_Missense_Mutation_p.H91L|PGAP3_uc010cvz.2_Missense_Mutation_p.H91L|ERBB2_uc002hsl.2_5'Flank	NM_033419	NP_219487	Q96FM1	PGAP3_HUMAN	per1-like domain containing 1 precursor	91	Lumenal (Potential).				GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			upper_aerodigestive_tract(1)	1						CACCTTGCCATGGAACTGAGG	0.537													13	17					0	0	0	0	A	37842182	A	A	37842182	3	1	88	1	0	0	0	0	1	0	0	0	11834	1464	51	5	718	5	PGAP3	17	37842182	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	4888820	37842182	43353028	126	17551											
B4GALNT2	124872	broad.mit.edu	37	chr17	47243530	47243530	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtcaccaccaaatacgttCtctgggtggacgatgatttt	10	12	10	9	2	2	1	1	1	1	0	3	3	2	2	2	3	1	1	2	3	2	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:47243530C>T	uc002ion.2	+	9	1248	c.1189C>T	c.(1189-1191)CTC>TTC	p.L397F	B4GALNT2_uc010wlt.1_Missense_Mutation_p.L311F|B4GALNT2_uc010wlu.1_Missense_Mutation_p.L337F	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	397	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			CAAATACGTTCTCTGGGTGGA	0.468													27	51					0	0	0	0	T	47243530	T	T	47243530	3	4	88	1	0	0	0	0	1	0	0	0	1269	913	32	2	1241	2	B4GALNT2	17	47243530	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	9401348	47243530	33951680	127	17552											
WFIKKN2	124857	broad.mit.edu	37	chr17	48916922	48916922	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accaagagctgcgtggcggcCcgctacatggacgtgaaagg	10	5	15	11	4	0	2	0	1	0	1	0	3	0	3	2	4	3	2	2	4	3	1			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:48916922C>A	uc002isv.3	+	2	967	c.273C>A	c.(271-273)GCC>GCA	p.A91A	WFIKKN2_uc010dbu.2_5'UTR	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	91	WAP.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GCGTGGCGGCCCGCTACATGG	0.582													14	21					1.49906e-05	7.66826e-05	1	0	A	48916922	A	A	48916922	2	1	88	1	0	0	0	0	0	0	0	1	17427	610	22	4		4	WFIKKN2	17	48916922	Silent	SNP	C	TCGA-CN-6997-01A-11D-2012-08	1673392	48916922	32278288	128	17553											
KIF2B	84643	broad.mit.edu	37	chr17	51901863	51901863	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctttgggtcagaacaagcCtcacaccccattcagagcca	11	7	9	14	0	3	2	3	0	0	2	3	2	3	2	4	2	3	1	4	2	2	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:51901863C>A	uc002iua.2	+	1	1625	c.1469C>A	c.(1468-1470)CCT>CAT	p.P490H	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	490					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CAGAACAAGCCTCACACCCCA	0.527													15	27					2.31682e-05	0.000117867	1	0	A	51901863	A	A	51901863	3	1	88	1	0	0	0	0	1	0	0	0	8337	681	24	4	1471	4	KIF2B	17	51901863	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	2984941	51901863	29293347	129	17554											
EMILIN2	84034	broad.mit.edu	37	chr18	2891658	2891658	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcctacagatgaccaataaCactggtgcagagctcagtcc	12	8	8	13	0	1	3	1	1	0	2	3	3	3	3	3	1	4	2	3	1	3	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:2891658C>A	uc002kln.2	+	4	1692	c.1533C>A	c.(1531-1533)AAC>AAA	p.N511K		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	511					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		TGACCAATAACACTGGTGCAG	0.527													36	52					2.04263e-09	1.0744e-08	1	0	A	2891658	A	A	2891658	3	1	88	1	0	0	0	0	1	0	0	0	5118	477	17	4	1547	4	EMILIN2	18	2891658	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08		2891658	75185590	130	17555											
MYL12B	103910	broad.mit.edu	37	chr18	3273065	3273065	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaaggaagatttgcatgatAtgcttgcttctctaggtaga	12	13	10	6	0	1	3	0	1	1	2	2	4	1	4	0	2	3	4	0	2	5	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:3273065A>G	uc010dkl.2	+	2	328	c.169A>G	c.(169-171)ATG>GTG	p.M57V	MYL12B_uc002klt.3_Missense_Mutation_p.M35V|MYL12B_uc010wyv.1_Missense_Mutation_p.M57V	NM_001144944	NP_001138416	O14950	ML12B_HUMAN	myosin regulatory light chain MRCL2 isoform A	57	EF-hand 1.				axon guidance|muscle contraction	cytosol|myosin complex	calcium ion binding				0						TTTGCATGATATGCTTGCTTC	0.343													98	24					0	0	0	0	G	3273065	G	G	3273065	3	3	88	1	0	0	0	0	1	0	0	0	10099	449	16	5	171	5	MYL12B	18	3273065	Missense_Mutation	SNP	A	TCGA-CN-6997-01A-11D-2012-08	381407	3273065	74804183	131	17556											
LAMA1	284217	broad.mit.edu	37	chr18	6976021	6976021	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggtattgtagttggtagagGaaatctgaggctggtaggcc	10	11	16	4	0	1	2	0	1	1	1	1	3	1	3	1	6	0	6	1	6	5	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:6976021G>A	uc002knm.2	-	45	6498	c.6404C>T	c.(6403-6405)TCC>TTC	p.S2135F	LAMA1_uc010wzj.1_Missense_Mutation_p.S1611F	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2135	Laminin G-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTTGGTAGAGGAAATCTGAGG	0.453													5	54					0	0	0	0	A	6976021	A	A	6976021	3	1	88	1	0	0	0	0	1	0	0	0	8645	1174	41	2	2899	2	LAMA1	18	6976021	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	3702956	6976021	71101227	132	17557											
SLC14A2	8170	broad.mit.edu	37	chr18	43224005	43224005	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgccaccatcatcttcctgCtcctgacgacaaacaaccca	11	9	4	17	1	2	1	1	1	1	0	4	2	4	1	5	0	4	1	5	0	2	2	rs139770269		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:43224005C>T	uc010dnj.2	+	11	1552	c.1231C>T	c.(1231-1233)CTC>TTC	p.L411F	SLC14A2_uc002lbb.2_Missense_Mutation_p.L411F|SLC14A2_uc002lbe.2_Missense_Mutation_p.L411F	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	411	Helical; (Potential).					apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CATCTTCCTGCTCCTGACGAC	0.547													73	103					0	0	0	0	T	43224005	T	T	43224005	3	4	88	1	0	0	0	0	1	0	0	0	14462	797	28	4	1265	4	SLC14A2	18	43224005	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	36247984	43224005	34853243	133	17558											
MYO5B	4645	broad.mit.edu	37	chr18	47390534	47390534	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcctgccggcgagtcgccGctggtcggcgctcacgatct	3	9	14	15	7	2	0	1	0	1	0	5	2	3	0	3	3	1	3	3	3	0	1			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:47390534G>A	uc002leb.2	-	28	4108	c.3820C>T	c.(3820-3822)CGG>TGG	p.R1274W	MYO5B_uc002lea.2_Missense_Mutation_p.R415W	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1274					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GCGAGTCGCCGCTGGTCGGCG	0.617													23	31					0	0	0	0	A	47390534	A	A	47390534	3	1	88	1	0	0	0	0	1	0	0	0	10132	1086	38	1	1778	1	MYO5B	18	47390534	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	4166529	47390534	30686714	134	17559											
MBD1	4152	broad.mit.edu	37	chr18	47800213	47800214	+	Frame_Shift_Ins	INS	-	AC	AC																															catcctcagactctgaccagINSacactgggcagcagccgctt																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:47800213_47800214insAC	uc010dow.1	-	12	1603_1604	c.1166_1167insGT	c.(1165-1167)GTCfs	p.V389fs	MBD1_uc002lef.2_Frame_Shift_Ins_p.V140fs|MBD1_uc002leg.2_Frame_Shift_Ins_p.V339fs|MBD1_uc010xdi.1_Frame_Shift_Ins_p.V440fs|MBD1_uc002leh.3_Frame_Shift_Ins_p.V333fs|MBD1_uc002len.2_Frame_Shift_Ins_p.V389fs|MBD1_uc002lei.3_Frame_Shift_Ins_p.V389fs|MBD1_uc002lej.3_Frame_Shift_Ins_p.V333fs|MBD1_uc002lek.3_Frame_Shift_Ins_p.V340fs|MBD1_uc002lel.3_Frame_Shift_Ins_p.V366fs|MBD1_uc002lem.3_Frame_Shift_Ins_p.V389fs|MBD1_uc010xdj.1_Frame_Shift_Ins_p.V333fs|MBD1_uc010xdk.1_Frame_Shift_Ins_p.V414fs|MBD1_uc010dox.1_Frame_Shift_Ins_p.V366fs|MBD1_uc002leo.2_Frame_Shift_Ins_p.V389fs	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	389					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ACTCTGACCAGACACTGGGCAG	0.609													---	---	---								AC	47800214	AC	AC	47800213	7	5	88	1	0	1	1	0	0	0	0	0	9395	929	33	0	864	0	MBD1	18	47800213	Frame_Shift_Ins	INS	-	TCGA-CN-6997-01A-11D-2012-08	409679	47800213	30277035	135	17560											
MEX3D	399664	broad.mit.edu	37	chr19	1556345	1556345	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcccagggccgtgtccccGcggaggccggccgtggccgt	2	4	18	17	7	0	0	0	0	0	0	1	1	1	1	7	5	0	0	7	5	0	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:1556345G>A	uc010dsn.2	-	2	1173	c.1173C>T	c.(1171-1173)CGC>CGT	p.R391R		NM_203304	NP_976049	Q86XN8	MEX3D_HUMAN	ring finger and KH domain containing 1	391					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGTGTCCCCGCGGAGGCCGG	0.801													8	7					0	0	0	0	A	1556345	A	A	1556345	2	1	88	1	0	0	0	0	0	0	0	1	9565	1074	38	1		1	MEX3D	19	1556345	Silent	SNP	G	TCGA-CN-6997-01A-11D-2012-08		1556345	57572638	136	17561											
ZNF559	84527	broad.mit.edu	37	chr19	9452988	9452988	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccccagatcttgctaaacaTataagacttagaactagagg	15	10	7	9	0	1	4	0	0	1	4	2	4	2	4	2	1	3	1	2	1	7	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:9452988T>G	uc002mlg.2	+	7	1508	c.861T>G	c.(859-861)CAT>CAG	p.H287Q	ZNF559_uc002mlf.2_Missense_Mutation_p.H56Q|ZNF559_uc010dwl.1_Missense_Mutation_p.H56Q|ZNF559_uc010xkn.1_Missense_Mutation_p.H279Q|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Missense_Mutation_p.H351Q|ZNF559_uc010dwk.1_Missense_Mutation_p.H56Q|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTGCTAAACATATAAGACTTA	0.333													37	62					0	0	0	0	G	9452988	G	G	9452988	3	3	88	1	0	0	0	0	1	0	0	0	18057	1403	49	5	875	5	ZNF559	19	9452988	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	7896643	9452988	49675995	137	17562											
QTRT1	81890	broad.mit.edu	37	chr19	10823850	10823850	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagaagcgcttcccggacttCgtgcgggacttcatgggcgc	6	8	15	12	5	1	1	1	0	0	1	3	4	2	3	1	3	2	1	1	3	1	3	rs139740339	byFrequency	TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:10823850C>T	uc002mpr.2	+	10	1141	c.1116C>T	c.(1114-1116)TTC>TTT	p.F372F	DNM2_uc010dxk.2_RNA	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	372					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			TCCCGGACTTCGTGCGGGACT	0.657													38	48					0	0	0	0	T	10823850	T	T	10823850	2	4	88	1	0	0	0	0	0	0	0	1	12950	883	31	1		1	QTRT1	19	10823850	Silent	SNP	C	TCGA-CN-6997-01A-11D-2012-08	1370862	10823850	48305133	138	17563											
CYP4F8	11283	broad.mit.edu	37	chr19	15733053	15733053	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agtggcaacgcctggccatgGagggcagcacctgtctggat	8	7	15	11	1	1	0	0	0	1	0	1	2	1	2	3	5	2	3	3	5	1	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:15733053G>C	uc002nbi.2	+	8	614	c.550G>C	c.(550-552)GAG>CAG	p.E184Q	CYP4F8_uc010xoj.1_Intron	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	184					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						CCTGGCCATGGAGGGCAGCAC	0.587													16	27					0	0	0	0	C	15733053	C	C	15733053	3	2	88	1	0	0	0	0	1	0	0	0	4208	1175	41	2	567	2	CYP4F8	19	15733053	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	4909203	15733053	43395930	139	17564											
MYO9B	4650	broad.mit.edu	37	chr19	17309083	17309083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acgcatcctccctcccagacGcagggctgtccccgggctct	5	7	10	19	3	1	1	0	0	1	1	5	1	5	1	5	2	0	4	5	2	0	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:17309083G>A	uc010eak.2	+	24	4356	c.4204G>A	c.(4204-4206)GCA>ACA	p.A1402T	MYO9B_uc002nfi.2_Missense_Mutation_p.A1402T|MYO9B_uc002nfj.1_Missense_Mutation_p.A1402T|MYO9B_uc002nfl.1_5'UTR	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1402	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CCTCCCAGACGCAGGGCTGTC	0.627													17	37					0	0	0	0	A	17309083	A	A	17309083	3	1	88	1	0	0	0	0	1	0	0	0	10138	1087	38	1	4294	1	MYO9B	19	17309083	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	1576030	17309083	41819900	140	17565											
UNC13A	23025	broad.mit.edu	37	chr19	17763482	17763482	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagacatctctccttctcccCgggcctgcaggacagacaga	9	8	9	15	1	2	3	0	0	2	3	5	4	3	4	4	2	1	1	4	2	1	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:17763482C>A	uc002nhd.2	-	13	1661	c.1661G>T	c.(1660-1662)CGG>CTG	p.R554L		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	466					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						TCCTTCTCCCCGGGCCTGCAG	0.532													101	198					1.43872e-54	8.37156e-54	1	0	A	17763482	A	A	17763482	3	1	88	1	0	0	0	0	1	0	0	0	17052	652	23	3	3838	3	UNC13A	19	17763482	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	454399	17763482	41365501	141	17566											
ZNF493	284443	broad.mit.edu	37	chr19	21606219	21606219	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taaccaggactcaaaccttaCtacacataagagaattcata	18	9	4	10	0	2	1	2	0	0	1	2	3	2	2	2	1	4	0	2	1	7	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:21606219C>G	uc002npx.2	+	2	654	c.374C>G	c.(373-375)ACT>AGT	p.T125S	ZNF493_uc002npw.2_Missense_Mutation_p.T253S|ZNF493_uc002npy.2_Missense_Mutation_p.T125S	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	125	C2H2-type 4; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCAAACCTTACTACACATAAG	0.373													13	36					0	0	0	0	G	21606219	G	G	21606219	3	3	88	1	0	0	0	0	1	0	0	0	18011	565	20	4	835	4	ZNF493	19	21606219	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	3842737	21606219	37522764	142	17567											
ZNF208	7757	broad.mit.edu	37	chr19	22154308	22154308	+	Frame_Shift_Del	DEL	T	-	-																															attgagaacataacaaagccTttgccacattcttcacattt																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:22154308delT	uc002nqp.2	-	6	3293	c.3144delA	c.(3142-3144)AAAfs	p.K1048fs	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAACAAAGCCTTTGCCACATT	0.383													---	---	---								-	22154308	-	-	22154308	7	5	88	1	0	1	0	1	0	0	0	0	17833	1606	56	0	318	0	ZNF208	19	22154308	Frame_Shift_Del	DEL	T	TCGA-CN-6997-01A-11D-2012-08	548089	22154308	36974675	143	17568											
ZNF675	171392	broad.mit.edu	37	chr19	23837318	23837318	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cattgaaacattttgctctgCatagttggtaaacattggtt	11	16	8	6	0	1	1	0	1	1	0	1	1	1	1	0	2	4	5	0	2	4	8			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:23837318C>A	uc002nri.2	-	4	599	c.417G>T	c.(415-417)ATG>ATT	p.M139I		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	139					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTTTGCTCTGCATAGTTGGTA	0.299													28	31					6.32553e-13	3.38452e-12	1	0	A	23837318	A	A	23837318	3	1	88	1	0	0	0	0	1	0	0	0	18149	710	25	4	1293	4	ZNF675	19	23837318	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	1683010	23837318	35291665	144	17569											
SUPT5H	6829	broad.mit.edu	37	chr19	39964118	39964118	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcagccgcactcctgccCagagtggggcctgggacccc	6	5	14	16	1	0	1	0	0	0	1	1	2	1	2	6	4	2	2	6	4	0	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:39964118C>A	uc002olo.3	+	25	2628	c.2449C>A	c.(2449-2451)CAG>AAG	p.Q817K	SUPT5H_uc002olp.3_Missense_Mutation_p.Q817K|SUPT5H_uc002olq.3_Missense_Mutation_p.Q813K|SUPT5H_uc002oln.3_Missense_Mutation_p.Q817K|SUPT5H_uc002olr.3_Missense_Mutation_p.Q817K|SUPT5H_uc002ols.1_Missense_Mutation_p.Q440K|SUPT5H_uc010egp.1_3'UTR	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	817	CTR1-9.|9 X 7 AA approximate tandem repeats of G- S-[QR]-T-P-X-[YQ], motif CTR1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CACTCCTGCCCAGAGTGGGGC	0.622													29	14					7.26314e-15	3.90866e-14	1	0	A	39964118	A	A	39964118	3	1	88	1	0	0	0	0	1	0	0	0	15465	595	21	4	2543	4	SUPT5H	19	39964118	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	16126800	39964118	19164865	145	17570											
CADM4	199731	broad.mit.edu	37	chr19	44127586	44127586	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actggcttcgtgggtcagatAggaacctgagggggtgacag	9	8	17	7	1	1	3	1	2	0	1	2	4	1	4	1	5	1	1	1	5	2	2			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:44127586A>T	uc002oxc.1	-	9	1112	c.1063T>A	c.(1063-1065)TAT>AAT	p.Y355N		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	355	Cytoplasmic (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				TGGGTCAGATAGGAACCTGAG	0.483													82	20					0	0	0	0	T	44127586	T	T	44127586	3	4	88	1	0	0	0	0	1	0	0	0	2581	420	15	5	107	5	CADM4	19	44127586	Missense_Mutation	SNP	A	TCGA-CN-6997-01A-11D-2012-08	4163468	44127586	15001397	146	17571											
ZC3H4	23211	broad.mit.edu	37	chr19	47584783	47584783	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattaccttatccaagagcTccctcgtctcttcggtcaga	9	12	6	14	2	2	2	1	0	1	2	7	2	4	2	3	1	2	1	3	1	3	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:47584783T>A	uc002pga.3	-	11	1465	c.1427A>T	c.(1426-1428)GAG>GTG	p.E476V	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	476							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		ATCCAAGAGCTCCCTCGTCTC	0.577													22	12					0	0	0	0	A	47584783	A	A	47584783	3	1	88	1	0	0	0	0	1	0	0	0	17637	1551	54	5	2504	5	ZC3H4	19	47584783	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	3457197	47584783	11544200	147	17572											
CD33	945	broad.mit.edu	37	chr19	51728579	51728579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cactttcttccatcccatacCctactacgacaagaactccc	11	10	2	18	1	1	1	0	0	1	1	4	2	4	1	4	0	4	0	4	0	5	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:51728579C>T	uc002pwa.2	+	2	183	c.143C>T	c.(142-144)CCC>CTC	p.P48L	CD33_uc010eos.1_Missense_Mutation_p.P48L|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	48	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CATCCCATACCCTACTACGAC	0.517													11	66					0	0	0	0	T	51728579	T	T	51728579	3	4	88	1	0	0	0	0	1	0	0	0	3020	623	22	4	149	4	CD33	19	51728579	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	4143796	51728579	7400404	148	17573											
ZNF677	342926	broad.mit.edu	37	chr19	53740901	53740901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcatgaccccaaaggtgtGaacgctggataaatgcctta	12	11	9	9	1	1	2	1	2	0	0	1	3	1	3	3	2	2	1	3	2	5	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:53740901G>A	uc002qbf.1	-	5	1264	c.1079C>T	c.(1078-1080)TCA>TTA	p.S360L	ZNF677_uc002qbg.1_Missense_Mutation_p.S360L	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	360	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		CCAAAGGTGTGAACGCTGGAT	0.393													38	13					0	0	0	0	A	53740901	A	A	53740901	3	1	88	1	0	0	0	0	1	0	0	0	18151	1294	45	2	679	2	ZNF677	19	53740901	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	2012322	53740901	5388082	149	17574											
LILRA2	11027	broad.mit.edu	37	chr19	55085312	55085312	+	Translation_Start_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgccagcactgagggctcatCcatccgcagagcagggcagt	9	6	13	13	1	1	2	1	1	0	1	3	2	3	2	3	2	3	5	3	2	0	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:55085312C>G	uc002qgg.3	+	1	56	c.-33C>G	c.(-35--31)ATCCA>ATGCA		LILRA2_uc010ern.2_Translation_Start_Site|LILRA2_uc002qgf.2_Translation_Start_Site|LILRA2_uc010yfe.1_Translation_Start_Site|LILRA2_uc010yff.1_Translation_Start_Site|LILRA2_uc010ero.2_Translation_Start_Site|LILRA2_uc010yfg.1_Translation_Start_Site	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,						defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		GAGGGCTCATCCATCCGCAGA	0.577													28	16					0	0	0	0	G	55085312	G	G	55085312	1	3	88	1	0	0	0	0	0	0	0	0	8826	870	30	2		2	LILRA2	19	55085312	Translation_Start_Site	SNP	C	TCGA-CN-6997-01A-11D-2012-08	1344411	55085312	4043671	150	17575											
PLCB4	5332	broad.mit.edu	37	chr20	9353027	9353027	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagatttgtcctcggacagaTatagaagatcttttcaaaaa	16	12	7	6	1	2	4	1	0	1	4	4	5	3	5	1	1	0	0	1	1	6	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:9353027T>A	uc002wnf.2	+	10	799	c.663T>A	c.(661-663)GAT>GAA	p.D221E	PLCB4_uc010gbw.1_Missense_Mutation_p.D221E|PLCB4_uc010gbx.2_Missense_Mutation_p.D221E|PLCB4_uc002wne.2_Missense_Mutation_p.D221E|PLCB4_uc002wnh.2_Missense_Mutation_p.D68E	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	221					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CTCGGACAGATATAGAAGATC	0.308													14	36					0	0	0	0	A	9353027	A	A	9353027	3	1	88	1	0	0	0	0	1	0	0	0	12085	1403	49	5	693	5	PLCB4	20	9353027	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08		9353027	53672493	151	17576											
NAA20	51126	broad.mit.edu	37	chr20	20013295	20013295	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagcctgatgaggacgcttAtggtaagctcccttccatgg	8	10	13	10	1	0	2	0	2	0	0	2	4	2	4	3	4	2	3	3	4	2	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:20013295A>G	uc002wrp.2	+	5	553	c.449A>G	c.(448-450)TAT>TGT	p.Y150C	NAA20_uc002wrq.2_Intron|NAA20_uc002wrr.2_Missense_Mutation_p.Y138C	NM_016100	NP_057184	P61599	NAA20_HUMAN	N-acetyltransferase 5 isoform a	150	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity				0						GAGGACGCTTATGGTAAGCTC	0.408													25	31					0	0	0	0	G	20013295	G	G	20013295	3	3	88	1	0	0	0	0	1	0	0	0	10173	449	16	5	488	5	NAA20	20	20013295	Missense_Mutation	SNP	A	TCGA-CN-6997-01A-11D-2012-08	10660268	20013295	43012225	152	17577											
CD93	22918	broad.mit.edu	37	chr20	23065386	23065386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctcctttgtcctcctcatCggggggcccagatggtggtc	3	12	12	14	1	2	1	1	0	1	1	7	1	4	1	4	5	0	0	4	5	0	1	rs142122866		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:23065386C>T	uc002wsv.2	-	1	1592	c.1444G>A	c.(1444-1446)GAT>AAT	p.D482N		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	482	Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TCCTCCTCATCGGGGGGCCCA	0.657													35	40					0	0	0	0	T	23065386	T	T	23065386	3	4	88	1	0	0	0	0	1	0	0	0	3062	884	31	1	522	1	CD93	20	23065386	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	3052091	23065386	39960134	153	17578											
NINL	22981	broad.mit.edu	37	chr20	25485703	25485703	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtcctcagaatcccaggTctgcagctgtcctgaagcaa	12	8	9	12	0	2	2	1	1	1	1	5	2	5	2	3	1	3	3	3	1	4	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:25485703T>C	uc002wux.1	-	6	603	c.529A>G	c.(529-531)ACC>GCC	p.T177A	NINL_uc010gdn.1_Missense_Mutation_p.T177A|NINL_uc010gdo.1_Missense_Mutation_p.T17A|NINL_uc010ztf.1_Missense_Mutation_p.T193A	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	177					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GAATCCCAGGTCTGCAGCTGT	0.443													4	9					0	0	0	0	C	25485703	C	C	25485703	3	2	88	1	0	0	0	0	1	0	0	0	10474	1667	58	5	3695	5	NINL	20	25485703	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08	2420317	25485703	37539817	154	17579											
PHACTR3	116154	broad.mit.edu	37	chr20	58342414	58342414	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cactgctgcccactccgccaCccaaggcaagctccaaaacc	11	4	6	20	1	0	0	0	0	0	0	2	0	2	0	6	1	4	3	6	1	4	0			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:58342414C>T	uc002yau.2	+	5	1182	c.715C>T	c.(715-717)CCC>TCC	p.P239S	PHACTR3_uc002yat.2_Missense_Mutation_p.P236S|PHACTR3_uc010zzw.1_Missense_Mutation_p.P198S|PHACTR3_uc002yav.2_Missense_Mutation_p.P198S|PHACTR3_uc002yaw.2_Missense_Mutation_p.P198S|PHACTR3_uc002yax.2_Intron	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	239	Pro-rich.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CACTCCGCCACCCAAGGCAAG	0.537													21	24					0	0	0	0	T	58342414	T	T	58342414	3	4	88	1	0	0	0	0	1	0	0	0	11866	507	18	4	733	4	PHACTR3	20	58342414	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	32856711	58342414	4683106	155	17580											
PPP1R3D	5509	broad.mit.edu	37	chr20	58514574	58514577	+	Frame_Shift_Del	DEL	TTGA	-	-																															tgctgcagcacaggtccgagTtgattgcgagccgcgacagc																										TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:58514574_58514577delTTGA	uc002ybb.2	-	1	776_779	c.410_413delTCAA	c.(409-414)ATCAACfs	p.I137fs	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	137_138					glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			CAGGTCCGAGTTGATTGCGAGCCG	0.681													---	---	---								-	58514577	-	-	58514574	7	5	88	1	0	1	0	1	0	0	0	0	12434	1725	60	0	490	0	PPP1R3D	20	58514574	Frame_Shift_Del	DEL	TTGA	TCGA-CN-6997-01A-11D-2012-08	172160	58514574	4510946	156	17581											
NCAM2	4685	broad.mit.edu	37	chr21	22849748	22849748	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgggatattctgaaccgaCagtttatgaattcagcatgc	12	13	9	7	1	2	2	1	2	1	0	2	4	2	3	1	1	3	2	1	1	4	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr21:22849748C>G	uc002yld.1	+	15	2282	c.2033C>G	c.(2032-2034)ACA>AGA	p.T678R	NCAM2_uc011acb.1_Missense_Mutation_p.T536R	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	678	Fibronectin type-III 2.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TCTGAACCGACAGTTTATGAA	0.368													16	14					0	0	0	0	G	22849748	G	G	22849748	3	3	88	1	0	0	0	0	1	0	0	0	10257	478	17	4	2091	4	NCAM2	21	22849748	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08		22849748	25280147	157	17582											
GART	2618	broad.mit.edu	37	chr21	34877966	34877966	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggactaggtcaattgcaCtgtcaaattctacacgattt	13	12	7	9	1	3	0	2	0	1	0	3	2	3	1	0	2	2	1	0	2	5	5			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr21:34877966C>G	uc002yrx.2	-	20	2762	c.2627G>C	c.(2626-2628)AGT>ACT	p.S876T	GART_uc002yrz.2_Missense_Mutation_p.S876T|GART_uc010gmd.2_Missense_Mutation_p.S538T|GART_uc002yry.2_Missense_Mutation_p.S876T	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	876	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	GTCAATTGCACTGTCAAATTC	0.338													22	6					0	0	0	0	G	34877966	G	G	34877966	3	3	88	1	0	0	0	0	1	0	0	0	6278	565	20	4	417	4	GART	21	34877966	Missense_Mutation	SNP	C	TCGA-CN-6997-01A-11D-2012-08	12028218	34877966	13251929	158	17583											
PI4KA	5297	broad.mit.edu	37	chr22	21178651	21178651	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatccctataggccacatcaGacagcagagttaccaagcag	14	6	9	12	0	1	2	1	0	0	2	2	3	2	2	3	1	3	3	3	1	4	3			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr22:21178651G>A	uc002zsz.3	-	4	476	c.245C>T	c.(244-246)TCT>TTT	p.S82F	PI4KA_uc010gsq.1_Missense_Mutation_p.S140F	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	82					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GGCCACATCAGACAGCAGAGT	0.443													18	33					0	0	0	0	A	21178651	A	A	21178651	3	1	88	1	0	0	0	0	1	0	0	0	11928	942	33	2	6097	2	PI4KA	22	21178651	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08		21178651	30125915	159	17584											
THOC2	57187	broad.mit.edu	37	chrX	122774415	122774415	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacaaaatggttggattgcTgtggctcaacttcccaattt	12	13	8	8	0	1	0	1	0	0	0	2	1	2	1	1	3	3	3	1	3	5	4			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chrX:122774415T>C	uc004etu.2	-	16	1752	c.1720A>G	c.(1720-1722)AGC>GGC	p.S574G	THOC2_uc011muh.1_Missense_Mutation_p.S495G	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	574					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						GTTGGATTGCTGTGGCTCAAC	0.383													60	5					0	0	0	0	C	122774415	C	C	122774415	3	2	88	1	0	0	0	0	1	0	0	0	15931	1580	55	5	3153	5	THOC2	23	122774415	Missense_Mutation	SNP	T	TCGA-CN-6997-01A-11D-2012-08		122774415	32496145	160	17585											
GPR112	139378	broad.mit.edu	37	chrX	135404984	135404984	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggatttttttggaagaggtGacacatatgtaagcctgata	12	14	11	4	0	0	3	0	2	0	1	0	5	0	5	1	3	1	1	1	3	4	6			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chrX:135404984G>C	uc004ezu.1	+	5	409	c.118G>C	c.(118-120)GAC>CAC	p.D40H	GPR112_uc010nsb.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	40	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TGGAAGAGGTGACACATATGT	0.388													38	9					0	0	0	0	C	135404984	C	C	135404984	3	2	88	1	0	0	0	0	1	0	0	0	6667	1290	45	2	124	2	GPR112	23	135404984	Missense_Mutation	SNP	G	TCGA-CN-6997-01A-11D-2012-08	12630569	135404984	19865576	161	17586											
DDI2	84301	broad.mit.edu	37	chr1	15956839	15956839	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttaccccgaatagatttCagtagtatagctgtgcctgg	10	12	10	9	1	1	1	1	0	0	1	1	3	1	1	3	1	3	3	3	1	6	6			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:15956839C>T	uc001awx.1	+	3	384	c.288C>T	c.(286-288)TTC>TTT	p.F96F	DDI2_uc001aww.2_Silent_p.F96F|DDI2_uc009voj.1_5'UTR	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	96					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		GAATAGATTTCAGTAGTATAG	0.463													30	56					0	0	0	0	T	15956839	T	T	15956839	2	4	89	1	0	0	0	0	0	0	0	1	4346	825	29	2		2	DDI2	1	15956839	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08		15956839	233293782	1	17587											
CDC42	998	broad.mit.edu	37	chr1	22408230	22408230	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttaggtttttgacaactatGcagtcacagttatgattggt	10	17	9	5	0	1	2	1	2	0	0	1	2	1	2	0	2	2	3	0	2	4	7			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:22408230G>A	uc001bfq.2	+	4	413	c.121G>A	c.(121-123)GCA>ACA	p.A41T	CDC42_uc009vqg.1_Missense_Mutation_p.A41T|CDC42_uc001bfp.2_Missense_Mutation_p.A41T|CDC42_uc001bfr.2_Missense_Mutation_p.A41T|CDC42_uc010odr.1_Missense_Mutation_p.A86T|CDC42_uc010ods.1_Missense_Mutation_p.A83T|CDC42_uc009vqh.2_Intron	NM_001039802	NP_001034891	P60953	CDC42_HUMAN	cell division cycle 42 isoform 1	41					actin cytoskeleton organization|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|establishment or maintenance of cell polarity|macrophage differentiation|muscle cell differentiation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of protein complex assembly|positive regulation of muscle cell differentiation|positive regulation of pseudopodium assembly|regulation of filopodium assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|filopodium|plasma membrane	GTP binding|GTPase activity|protein binding|thioesterase binding			haematopoietic_and_lymphoid_tissue(1)	1		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)|Prostate(1639;0.0792)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0452)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.35e-07)|COAD - Colon adenocarcinoma(152;7.73e-06)|GBM - Glioblastoma multiforme(114;8.62e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000649)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00767)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.207)		TGACAACTATGCAGTCACAGT	0.348													35	63					0	0	0	0	A	22408230	A	A	22408230	3	1	89	1	0	0	0	0	1	0	0	0	3086	1319	46	4	127	4	CDC42	1	22408230	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	6451391	22408230	226842391	2	17588											
EPHA10	284656	broad.mit.edu	37	chr1	38227344	38227344	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcgccacgcatgcgcccaCgtcctgaaaggccaggtgga	10	4	13	14	4	0	1	0	1	0	0	1	2	1	2	4	3	2	1	4	3	2	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:38227344C>T	uc009vvi.2	-	3	669	c.583G>A	c.(583-585)GTG>ATG	p.V195M	EPHA10_uc001cbw.3_Missense_Mutation_p.V195M	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	195	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CATGCGCCCACGTCCTGAAAG	0.682													18	43					0	0	0	0	T	38227344	T	T	38227344	3	4	89	1	0	0	0	0	1	0	0	0	5190	536	19	1	2541	1	EPHA10	1	38227344	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	15819114	38227344	211023277	3	17589											
GLIS1	148979	broad.mit.edu	37	chr1	53972293	53972293	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgcatgtgggggctccttCaggtgtctgtgtagatggag	5	11	18	7	1	2	1	1	0	1	1	3	2	3	2	1	5	0	3	1	5	1	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:53972293C>T	uc001cvr.1	-	10	2429	c.1862G>A	c.(1861-1863)TGA>TAA	p.*621*		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	621					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						GGGGCTCCTTCAGGTGTCTGT	0.642													20	40					0	0	0	0	T	53972293	T	T	53972293	2	4	89	1	0	0	0	0	0	0	0	1	6482	837	29	2		2	GLIS1	1	53972293	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	15744949	53972293	195278328	4	17590											
PRKAA2	5563	broad.mit.edu	37	chr1	57161705	57161705	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgatgatgagcatgtacctAcgttatttaagaagatccga	13	13	9	6	2	0	5	0	3	0	2	1	6	1	5	2	0	3	3	2	0	5	6			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:57161705A>G	uc001cyk.3	+	6	732	c.661A>G	c.(661-663)ACG>GCG	p.T221A		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	221	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						GCATGTACCTACGTTATTTAA	0.448													137	179					0	0	0	0	G	57161705	G	G	57161705	3	3	89	1	0	0	0	0	1	0	0	0	12556	391	14	5	683	5	PRKAA2	1	57161705	Missense_Mutation	SNP	A	TCGA-CN-6998-01A-23D-2012-08	3189412	57161705	192088916	5	17591											
LRRC8B	23507	broad.mit.edu	37	chr1	90049999	90049999	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaactgatcagctgtgaccTggaacgcatcccacattcca	12	8	8	13	1	1	3	1	2	0	1	3	4	3	4	3	1	3	2	3	1	2	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:90049999T>C	uc001dni.2	+	7	2297	c.1790T>C	c.(1789-1791)CTG>CCG	p.L597P	LRRC8B_uc001dnh.2_Missense_Mutation_p.L597P|LRRC8B_uc001dnj.2_Missense_Mutation_p.L597P	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	597	LRR 6.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		AGCTGTGACCTGGAACGCATC	0.403													3	52					0	0	0	0	C	90049999	C	C	90049999	3	2	89	1	0	0	0	0	1	0	0	0	9072	1580	55	5	1792	5	LRRC8B	1	90049999	Missense_Mutation	SNP	T	TCGA-CN-6998-01A-23D-2012-08	32888294	90049999	159200622	6	17592											
NBPF9	400818	broad.mit.edu	37	chr1	144814712	144814712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctggttcacgctcaggaacGagagctgacccagttaaggg	10	7	13	11	2	2	2	2	1	0	1	2	4	2	3	2	3	2	4	2	3	2	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:144814712G>A	uc009wig.1	+	11	1200	c.1124G>A	c.(1123-1125)CGA>CAA	p.R375Q	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.R375Q|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.R306Q|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Missense_Mutation_p.R306Q|NBPF9_uc010oyg.1_Missense_Mutation_p.R340Q|NBPF9_uc009wii.1_Missense_Mutation_p.R104Q|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Missense_Mutation_p.R35Q	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	375	Potential.					cytoplasm					0						GCTCAGGAACGAGAGCTGACC	0.507													87	129					0	0	0	0	A	144814712	A	A	144814712	3	1	89	1	0	0	0	0	1	0	0	0	10253	1058	37	1	1152	1	NBPF9	1	144814712	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	54764713	144814712	104435909	7	17593											
C1orf43	25912	broad.mit.edu	37	chr1	154179930	154179930	+	Nonstop_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caagagtccttcagctccgtCacagagtactctccaatgtg	10	10	8	13	1	3	2	2	0	1	2	6	2	5	2	3	0	2	2	3	0	3	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:154179930C>G	uc001fei.2	-	7	1151	c.761G>C	c.(760-762)TGA>TCA	p.*254S	C1orf189_uc001fee.1_5'Flank|C1orf43_uc001fef.1_Nonstop_Mutation_p.*151S|C1orf43_uc001feg.2_Nonstop_Mutation_p.*220S|C1orf43_uc001feh.2_Nonstop_Mutation_p.*202S|C1orf43_uc001fej.2_Nonstop_Mutation_p.*236S|C1orf43_uc009wos.1_3'UTR	NM_001098616	NP_001092086	Q9BWL3	CA043_HUMAN	hypothetical protein LOC25912 isoform 3	254						integral to membrane	coenzyme binding|oxidoreductase activity				0	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					TCAGCTCCGTCACAGAGTACT	0.517													3	159					0	0	0	0	G	154179930	G	G	154179930	4	3	89	1	0	0	0	0	0	0	0	0	2050	837	29	2	4	2	C1orf43	1	154179930	Nonstop_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	9365218	154179930	95070691	8	17594											
BCAN	63827	broad.mit.edu	37	chr1	156628471	156628471	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatctgccgctgatccgatgCcaagagaacggtcgttggga	10	8	13	10	4	1	2	0	1	1	1	3	5	2	3	3	2	3	2	3	2	3	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:156628471C>T	uc001fpp.2	+	13	2910	c.2574C>T	c.(2572-2574)TGC>TGT	p.C858C		NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	858	Sushi.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGATCCGATGCCAAGAGAACG	0.627													32	82					0	0	0	0	T	156628471	T	T	156628471	2	4	89	1	0	0	0	0	0	0	0	1	1347	747	26	4		4	BCAN	1	156628471	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	2448541	156628471	92622150	9	17595											
ASTN1	460	broad.mit.edu	37	chr1	176833525	176833525	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccgcccagtcaagtccgtaGggtttgatctcgctgtagcg	6	11	12	12	4	2	1	1	1	1	0	5	1	4	1	3	1	1	4	3	1	3	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:176833525G>A	uc001glc.2	-	23	3992	c.3780C>T	c.(3778-3780)CCC>CCT	p.P1260P	ASTN1_uc001glb.1_Intron	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1268					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CAAGTCCGTAGGGTTTGATCT	0.572													31	83					0	0	0	0	A	176833525	A	A	176833525	2	1	89	1	0	0	0	0	0	0	0	1	1066	987	35	4		4	ASTN1	1	176833525	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08	20205054	176833525	72417096	10	17596											
KCNT2	343450	broad.mit.edu	37	chr1	196311261	196311262	+	Frame_Shift_Ins	INS	-	A	A																															ctctttccttcatattcagcINSaaaaaatgtactttcttcca																										TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:196311261_196311262insA	uc001gtd.1	-	15	1560_1561	c.1500_1501insT	c.(1498-1503)TTTGCTfs	p.F500fs	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Intron|KCNT2_uc001gtf.1_Frame_Shift_Ins_p.F500fs|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Frame_Shift_Ins_p.F500fs|KCNT2_uc001gth.1_Frame_Shift_Ins_p.F21fs	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	500_501	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TCATATTCAGCAAAAAATGTAC	0.391													---	---	---								A	196311262	A	A	196311261	7	5	89	1	0	1	1	0	0	0	0	0	8131	710	25	0	1962	0	KCNT2	1	196311261	Frame_Shift_Ins	INS	-	TCGA-CN-6998-01A-23D-2012-08	19477736	196311261	52939360	11	17597											
KCNH1	3756	broad.mit.edu	37	chr1	210971026	210971026	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactggccagccggaaggccGggtgctccttgaacaccttg	7	7	13	14	2	0	1	0	1	0	0	1	2	1	2	5	4	3	1	5	4	2	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:210971026G>A	uc001hib.2	-	9	1909	c.1739C>T	c.(1738-1740)CCG>CTG	p.P580L	KCNH1_uc001hic.2_Missense_Mutation_p.P553L	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	580	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCGGAAGGCCGGGTGCTCCTT	0.607													22	47					0	0	0	0	A	210971026	A	A	210971026	3	1	89	1	0	0	0	0	1	0	0	0	8070	1116	39	1	1242	1	KCNH1	1	210971026	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	14659765	210971026	38279595	12	17598											
RSAD2	91543	broad.mit.edu	37	chr2	7027109	7027109	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcctgtgacagctttgaCgaggaagtcaatgtccttat	10	13	9	9	1	2	2	1	2	1	0	4	4	3	3	2	1	1	1	2	1	3	2	rs111620392	byFrequency	TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:7027109C>T	uc002qyp.1	+	3	688	c.552C>T	c.(550-552)GAC>GAT	p.D184D		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	184					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		ACAGCTTTGACGAGGAAGTCA	0.458													15	37					0	0	0	0	T	7027109	T	T	7027109	2	4	89	1	0	0	0	0	0	0	0	1	13760	535	19	1		1	RSAD2	2	7027109	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08		7027109	236172264	13	17599											
FOSL2	2355	broad.mit.edu	37	chr2	28627022	28627022	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtgcattcatccccaccAtcaacgccatcacgaccagc	11	6	6	18	2	3	0	3	0	0	0	4	1	4	0	5	0	3	2	5	0	1	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:28627022A>G	uc002rma.2	+	2	960	c.151A>G	c.(151-153)ATC>GTC	p.I51V	FOSL2_uc010ymi.1_Missense_Mutation_p.I12V	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	51					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					CATCCCCACCATCAACGCCAT	0.517													27	98					0	0	0	0	G	28627022	G	G	28627022	3	3	89	1	0	0	0	0	1	0	0	0	6020	217	8	5	157	5	FOSL2	2	28627022	Missense_Mutation	SNP	A	TCGA-CN-6998-01A-23D-2012-08	21599913	28627022	214572351	14	17600											
LIMS1	3987	broad.mit.edu	37	chr2	109292348	109292348	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggacaggaaggagctgactgCcgatgcacgggagctgaaag	12	4	17	8	2	0	2	0	2	0	0	0	7	0	6	1	4	4	3	1	4	2	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:109292348C>T	uc002teg.2	+	6	628	c.509C>T	c.(508-510)GCC>GTC	p.A170V	LIMS1_uc002tef.2_Missense_Mutation_p.A182V|LIMS1_uc002teh.2_Missense_Mutation_p.A170V|LIMS1_uc002tei.2_Missense_Mutation_p.A170V|LIMS1_uc002tej.2_Missense_Mutation_p.A207V|LIMS1_uc002tek.3_Missense_Mutation_p.A232V	NM_004987	NP_004978	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	170	LIM zinc-binding 3.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding				0						GAGCTGACTGCCGATGCACGG	0.527													4	93					0	0	0	0	T	109292348	T	T	109292348	3	4	89	1	0	0	0	0	1	0	0	0	8844	739	26	4	527	4	LIMS1	2	109292348	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	80665326	109292348	133907025	15	17601											
CNTNAP5	129684	broad.mit.edu	37	chr2	125282021	125282021	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttattctggaaatagctactAttttggaggtaaattctcca	12	16	7	6	0	2	0	0	0	2	0	3	2	2	2	1	3	2	2	1	3	7	9			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:125282021A>G	uc002tno.2	+	9	1830	c.1466A>G	c.(1465-1467)TAT>TGT	p.Y489C	CNTNAP5_uc010flu.2_Missense_Mutation_p.Y490C	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	489	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AATAGCTACTATTTTGGAGGT	0.448													16	19					0	0	0	0	G	125282021	G	G	125282021	3	3	89	1	0	0	0	0	1	0	0	0	3665	449	16	5	1500	5	CNTNAP5	2	125282021	Missense_Mutation	SNP	A	TCGA-CN-6998-01A-23D-2012-08	15989673	125282021	117917352	16	17602											
IWS1	55677	broad.mit.edu	37	chr2	128255753	128255753	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttatcatcagaatctgaatCttctgcttcttttacctgtg	8	18	6	9	0	6	2	2	1	4	1	6	2	6	2	1	0	2	2	1	0	4	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:128255753C>T	uc002ton.2	-	6	1831	c.1528G>A	c.(1528-1530)GAT>AAT	p.D510N	IWS1_uc010yzl.1_Intron	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	510					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		GAATCTGAATCTTCTGCTTCT	0.303													34	44					0	0	0	0	T	128255753	T	T	128255753	3	4	89	1	0	0	0	0	1	0	0	0	7970	913	32	2	967	2	IWS1	2	128255753	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	2973732	128255753	114943620	17	17603											
LCT	3938	broad.mit.edu	37	chr2	136575285	136575285	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacacctgagcccggaggcCgcaaagcagggcgacgtcag	10	3	15	13	4	1	1	1	1	0	0	1	3	1	2	3	3	3	3	3	3	2	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:136575285C>T	uc002tuu.1	-	6	1344	c.1333G>A	c.(1333-1335)GGC>AGC	p.G445S		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	445	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GCCCGGAGGCCGCAAAGCAGG	0.642													33	81					0	0	0	0	T	136575285	T	T	136575285	3	4	89	1	0	0	0	0	1	0	0	0	8733	652	23	1	4498	1	LCT	2	136575285	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	8319532	136575285	106624088	18	17604											
KIF5C	3800	broad.mit.edu	37	chr2	149868101	149868101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagccaagcccatccgccccGgacactacccggcctcatct	8	5	7	21	3	2	0	1	0	1	0	3	1	3	1	7	2	3	0	7	2	2	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:149868101G>A	uc010zbu.1	+	25	3153	c.2785G>A	c.(2785-2787)GGA>AGA	p.G929R	KIF5C_uc002tws.1_RNA|KIF5C_uc002twu.1_Missense_Mutation_p.G211R	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	929	Globular.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		CATCCGCCCCGGACACTACCC	0.498													4	82					0	0	0	0	A	149868101	A	A	149868101	3	1	89	1	0	0	0	0	1	0	0	0	8346	1117	39	1	2805	1	KIF5C	2	149868101	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	13292816	149868101	93331272	19	17605											
HECW2	57520	broad.mit.edu	37	chr2	197182030	197182030	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcgtccaccctctggtacCggctaacatcctggcgcact	6	9	8	18	3	1	0	0	0	1	0	4	0	3	0	5	3	2	3	5	3	2	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:197182030C>T	uc002utm.1	-	10	2585	c.2402G>A	c.(2401-2403)CGG>CAG	p.R801Q	HECW2_uc002utl.1_Missense_Mutation_p.R445Q	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	801	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CCTCTGGTACCGGCTAACATC	0.517													6	14					0	0	0	0	T	197182030	T	T	197182030	3	4	89	1	0	0	0	0	1	0	0	0	7082	652	23	1	2396	1	HECW2	2	197182030	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	47313929	197182030	46017343	20	17606											
FARSB	10056	broad.mit.edu	37	chr2	223520788	223520788	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacgcttcacgctgacagtcGgcatggtgtgtcgaactcac	8	9	11	13	4	2	1	2	1	0	0	4	2	2	1	0	2	1	3	0	2	1	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:223520788G>A	uc002vne.1	-	1	40	c.5C>T	c.(4-6)CCG>CTG	p.P2L	FARSB_uc010zlq.1_Missense_Mutation_p.P2L|FARSB_uc002vnf.1_5'UTR|FARSB_uc002vng.1_RNA	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	2					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	GCTGACAGTCGGCATGGTGTG	0.627													10	6					0	0	0	0	A	223520788	A	A	223520788	3	1	89	1	0	0	0	0	1	0	0	0	5712	1116	39	1	1832	1	FARSB	2	223520788	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	26338758	223520788	19678585	21	17607											
NEU2	4759	broad.mit.edu	37	chr2	233899356	233899356	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agccacctccgagccagggtCcaggcccagagcaccaatga	11	3	11	16	1	0	2	0	1	0	1	2	3	2	2	7	2	3	1	7	2	1	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:233899356C>T	uc010zmn.1	+	2	732	c.732C>T	c.(730-732)GTC>GTT	p.V244V		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	244							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		GAGCCAGGGTCCAGGCCCAGA	0.652													18	52					0	0	0	0	T	233899356	T	T	233899356	2	4	89	1	0	0	0	0	0	0	0	1	10396	842	30	2		2	NEU2	2	233899356	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	10378568	233899356	9300017	22	17608											
STK25	10494	broad.mit.edu	37	chr2	242438109	242438110	+	Frame_Shift_Ins	INS	-	A	A																															ccctctgacttccagcgcttINSatagcggtcgatgagctccg																										TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:242438109_242438110insA	uc002wbm.2	-	7	1132_1133	c.861_862insT	c.(859-864)TATAAGfs	p.Y287fs	STK25_uc002wbk.2_Frame_Shift_Ins_p.Y106fs|STK25_uc002wbl.2_3'UTR|STK25_uc002wbn.2_Frame_Shift_Ins_p.Y287fs|STK25_uc002wbo.2_Frame_Shift_Ins_p.Y210fs|STK25_uc010zos.1_Frame_Shift_Ins_p.Y193fs|STK25_uc010zot.1_Frame_Shift_Ins_p.Y213fs|STK25_uc002wbp.2_Frame_Shift_Ins_p.Y287fs|STK25_uc010fzo.2_Frame_Shift_Ins_p.Y210fs|STK25_uc010zou.1_Frame_Shift_Ins_p.Y193fs|STK25_uc010zov.1_Frame_Shift_Ins_p.Y193fs	NM_006374	NP_006365	O00506	STK25_HUMAN	serine/threonine kinase 25	287_288					response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		TTCCAGCGCTTATAGCGGTCGA	0.584													---	---	---								A	242438110	A	A	242438109	7	5	89	1	0	1	1	0	0	0	0	0	15360	1763	61	0	438	0	STK25	2	242438109	Frame_Shift_Ins	INS	-	TCGA-CN-6998-01A-23D-2012-08	8538753	242438109	761264	23	17609											
SUSD5	26032	broad.mit.edu	37	chr3	33195134	33195134	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttggtttcaggttcacctggGaccaattttacaccactgtg	8	14	9	10	0	2	0	2	0	0	0	2	1	2	1	3	3	1	2	3	3	2	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:33195134G>A	uc003cfo.1	-	5	1408	c.990C>T	c.(988-990)GTC>GTT	p.V330V		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	330	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						GTTCACCTGGGACCAATTTTA	0.517													17	12					0	0	0	0	A	33195134	A	A	33195134	2	1	89	1	0	0	0	0	0	0	0	1	15477	1161	41	2		2	SUSD5	3	33195134	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08		33195134	164827296	24	17610											
RHOA	387	broad.mit.edu	37	chr3	49412905	49412905	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatctgccacatagttctCaaacactgtgggcacataca	13	10	7	11	0	2	0	1	0	2	0	3	1	2	0	1	1	3	2	1	1	4	4			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:49412905C>G	uc003cwu.2	-	2	394	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	40	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATAGTTCTCAAACACTGTG	0.438													87	46					0	0	0	0	G	49412905	G	G	49412905	3	3	89	1	0	0	0	0	1	0	0	0	13396	835	29	2	479	2	RHOA	3	49412905	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	16217771	49412905	148609525	25	17611											
MAPKAPK3	7867	broad.mit.edu	37	chr3	50683618	50683618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caacacgggccaggccatctCcccggggatgaagaggagga	11	3	15	12	2	1	2	0	1	1	1	2	5	1	5	4	6	1	0	4	6	2	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:50683618C>T	uc003day.1	+	10	1348	c.752C>T	c.(751-753)TCC>TTC	p.S251F	MAPKAPK3_uc003daz.1_Missense_Mutation_p.S251F|MAPKAPK3_uc003dba.1_Missense_Mutation_p.S251F|MAPKAPK3_uc010hlr.1_Missense_Mutation_p.S251F	NM_004635	NP_004626	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated	251	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		CAGGCCATCTCCCCGGGGATG	0.597													94	58					0	0	0	0	T	50683618	T	T	50683618	3	4	89	1	0	0	0	0	1	0	0	0	9343	855	30	2	778	2	MAPKAPK3	3	50683618	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	1270713	50683618	147338812	26	17612											
CCDC66	285331	broad.mit.edu	37	chr3	56651600	56651600	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cattcatctcatcaagaaacGgagtcaaagttgaggtggca	14	9	10	8	1	4	2	4	1	1	1	5	3	4	3	0	3	1	2	0	3	3	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:56651600G>A	uc003dhz.2	+	14	2391	c.2304G>A	c.(2302-2304)ACG>ACA	p.T768T	CCDC66_uc003dhy.2_Silent_p.T404T|CCDC66_uc003dhu.2_Silent_p.T734T|CCDC66_uc003dhx.2_RNA|CCDC66_uc003dia.2_Silent_p.T136T	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	768										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		ATCAAGAAACGGAGTCAAAGT	0.378													10	15					0	0	0	0	A	56651600	A	A	56651600	2	1	89	1	0	0	0	0	0	0	0	1	2851	1103	39	1		1	CCDC66	3	56651600	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08	5967982	56651600	141370830	27	17613											
CNTN3	5067	broad.mit.edu	37	chr3	74315641	74315641	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccaacttactggttattcGtggaatcctgatctgttcac	10	14	7	10	1	2	1	1	1	1	0	4	2	3	2	2	2	3	2	2	2	5	4			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:74315641G>A	uc003dpm.1	-	21	3057	c.2977C>T	c.(2977-2979)CGA>TGA	p.R993*		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	993					cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CTGGTTATTCGTGGAATCCTG	0.428													89	67					0	0	0	0	A	74315641	A	A	74315641	4	1	89	1	0	0	0	0	0	1	0	0	3657	1153	40	1	117	1	CNTN3	3	74315641	Nonsense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	17664041	74315641	123706789	28	17614											
GRAMD1C	54762	broad.mit.edu	37	chr3	113659107	113659107	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttagcctctgatatggtgtCaagagcagaaactattcaga	13	12	9	7	0	3	4	2	1	1	3	3	4	3	4	1	1	3	1	1	1	5	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:113659107C>G	uc003eaq.3	+	17	1899	c.1823C>G	c.(1822-1824)TCA>TGA	p.S608*	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc003ear.2_Nonsense_Mutation_p.S441*|GRAMD1C_uc003eas.2_Nonsense_Mutation_p.S403*|GRAMD1C_uc003eat.2_Nonsense_Mutation_p.S267*	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	608						integral to membrane				ovary(2)|skin(1)	3						GATATGGTGTCAAGAGCAGAA	0.408													53	169					0	0	0	0	G	113659107	G	G	113659107	4	3	89	1	0	0	0	0	0	1	0	0	6788	838	29	2	1889	2	GRAMD1C	3	113659107	Nonsense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	39343466	113659107	84363323	29	17615											
SI	6476	broad.mit.edu	37	chr3	164777066	164777066	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcttgtcttccatgtagtCaatatcagtgacctgtgtat	8	18	7	8	0	4	1	2	1	2	0	5	1	5	1	2	0	0	2	2	0	4	6			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:164777066C>G	uc003fei.2	-	11	1230	c.1168G>C	c.(1168-1170)GAC>CAC	p.D390H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	390	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCCATGTAGTCAATATCAGTG	0.358										HNSCC(35;0.089)			7	52					0	0	0	0	G	164777066	G	G	164777066	3	3	89	1	0	0	0	0	1	0	0	0	14362	826	29	2	4467	2	SI	3	164777066	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	51117959	164777066	33245364	30	17616											
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	17	7	10	7	0	1	2	1	2	0	0	1	4	1	3	0	3	3	2	0	3	5	0	rs121913279		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			49	24					0	0	0	0	G	178952085	G	G	178952085	3	3	89	1	0	0	0	0	1	0	0	0	11968	217	8	5	3218	5	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-CN-6998-01A-23D-2012-08	14175019	178952085	19070345	31	17617											
TP63	8626	broad.mit.edu	37	chr3	189349311	189349311	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacagttgaaggaaatgaatTttgaaacttcacggtgtgcc	13	11	11	6	1	1	3	1	3	0	0	1	5	1	4	1	2	2	1	1	2	4	4			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:189349311T>C	uc003fry.2	+	1	96	c.7T>C	c.(7-9)TTT>CTT	p.F3L	TP63_uc003frx.2_Missense_Mutation_p.F3L|TP63_uc003frz.2_Missense_Mutation_p.F3L|TP63_uc010hzc.1_Missense_Mutation_p.F3L	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	3	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GGAAATGAATTTTGAAACTTC	0.378									Hay-Wells_syndrome	HNSCC(45;0.13)			73	70					0	0	0	0	C	189349311	C	C	189349311	3	2	89	1	0	0	0	0	1	0	0	0	16459	1841	64	5	9	5	TP63	3	189349311	Missense_Mutation	SNP	T	TCGA-CN-6998-01A-23D-2012-08	10397226	189349311	8673119	32	17618											
C3orf59	151963	broad.mit.edu	37	chr3	192516654	192516654	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcccagagcatcatgctccGcaggtgataggggctaatag	10	7	14	10	1	1	2	1	1	0	1	2	2	2	2	2	4	2	4	2	4	3	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:192516654G>T	uc011bsp.1	-	2	1318	c.997C>A	c.(997-999)CGG>AGG	p.R333R		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	333											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		ATCATGCTCCGCAGGTGATAG	0.552													28	82					9.04412e-07	1.03361e-06	1	0	T	192516654	T	T	192516654	2	4	89	1	0	0	0	0	0	0	0	1	2247	1086	38	3		3	C3orf59	3	192516654	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08	3167343	192516654	5505776	33	17619											
KIAA1211	57482	broad.mit.edu	37	chr4	57182124	57182124	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacacagagttcacgacctCgtcggacagcgagactgcaa	12	5	10	14	4	1	2	1	0	0	2	3	5	1	3	2	1	2	2	2	1	1	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:57182124C>T	uc003hbk.2	+	8	2847	c.2456C>T	c.(2455-2457)TCG>TTG	p.S819L	KIAA1211_uc010iha.2_Missense_Mutation_p.S812L|KIAA1211_uc011bzz.1_Missense_Mutation_p.S729L|KIAA1211_uc003hbm.1_Missense_Mutation_p.S705L	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	819										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					TTCACGACCTCGTCGGACAGC	0.537													25	54					0	0	0	0	T	57182124	T	T	57182124	3	4	89	1	0	0	0	0	1	0	0	0	8254	893	31	1	2474	1	KIAA1211	4	57182124	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08		57182124	133972152	34	17620											
AFM	173	broad.mit.edu	37	chr4	74351714	74351714	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaatctgatgtgggatttCtgcctcctttccctaccctg	7	14	8	12	0	2	2	0	1	2	1	4	3	4	3	4	1	2	0	4	1	2	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:74351714C>T	uc003hhb.2	+	4	437	c.406C>T	c.(406-408)CTG>TTG	p.L136L		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	136	Albumin 1.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGTGGGATTTCTGCCTCCTTT	0.398													16	39					0	0	0	0	T	74351714	T	T	74351714	2	4	89	1	0	0	0	0	0	0	0	1	361	912	32	2		2	AFM	4	74351714	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	17169590	74351714	116802562	35	17621											
ENPEP	2028	broad.mit.edu	37	chr4	111397714	111397714	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtgtgactccagcggggaCggcgggccgggcactgcgcc	4	5	18	14	6	0	1	0	1	0	0	2	2	1	2	3	5	2	1	3	5	0	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:111397714C>T	uc003iab.3	+	1	486	c.144C>T	c.(142-144)GAC>GAT	p.D48D		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	48	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CCAGCGGGGACGGCGGGCCGG	0.637													15	110					0	0	0	0	T	111397714	T	T	111397714	2	4	89	1	0	0	0	0	0	0	0	1	5152	535	19	1		1	ENPEP	4	111397714	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	37046000	111397714	79756562	36	17622											
MTNR1A	4543	broad.mit.edu	37	chr4	187454891	187454891	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttggtcatcagtggagaCggtttccatttaaccctatc	8	15	9	9	1	2	1	2	0	0	1	4	2	3	1	2	3	1	2	2	3	2	6			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:187454891C>T	uc003izd.1	-	2	1023	c.1005G>A	c.(1003-1005)CCG>CCA	p.P335P		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	335	Cytoplasmic (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TCAGTGGAGACGGTTTCCATT	0.493													24	68					0	0	0	0	T	187454891	T	T	187454891	2	4	89	1	0	0	0	0	0	0	0	1	10004	523	19	1		1	MTNR1A	4	187454891	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	76057177	187454891	3699385	37	17623											
TRIP13	9319	broad.mit.edu	37	chr5	908535	908535	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccatcagatgccatccgCgtggtcaatgctgtcttgac	8	10	11	12	2	3	2	2	1	1	1	4	3	4	2	3	1	3	1	3	1	1	1	rs146441673		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:908535C>T	uc003jbr.2	+	9	935	c.825C>T	c.(823-825)CGC>CGT	p.R275R	TRIP13_uc010ite.1_Silent_p.R275R	NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	275					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			ATGCCATCCGCGTGGTCAATG	0.522													22	65					0	0	0	0	T	908535	T	T	908535	2	4	89	1	0	0	0	0	0	0	0	1	16624	755	27	1		1	TRIP13	5	908535	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08		908535	180006725	38	17624											
MTRR	4552	broad.mit.edu	37	chr5	7870928	7870928	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgaggaggtttctgttactAtatgctacacagcagggaca	12	11	11	7	0	1	1	0	1	1	0	1	3	1	3	0	3	4	4	0	3	4	5	rs114427781	by1000genomes	TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:7870928A>G	uc003jed.2	+	2	132	c.102A>G	c.(100-102)CTA>CTG	p.L34L	FASTKD3_uc011cmp.1_5'Flank|FASTKD3_uc003jeb.2_5'Flank|FASTKD3_uc003jec.2_5'Flank|MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Silent_p.L7L|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	34	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TTCTGTTACTATATGCTACAC	0.403													24	30					0	0	0	0	G	7870928	G	G	7870928	2	3	89	1	0	0	0	0	0	0	0	1	10014	436	16	5		5	MTRR	5	7870928	Silent	SNP	A	TCGA-CN-6998-01A-23D-2012-08	6962393	7870928	173044332	39	17625											
MAP1B	4131	broad.mit.edu	37	chr5	71494372	71494372	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcaggtagaggcctccccGtccacctcttctgctcatac	6	11	7	17	1	4	1	2	0	3	1	7	1	6	1	5	2	2	2	5	2	2	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:71494372G>A	uc003kbw.3	+	5	5431	c.5190G>A	c.(5188-5190)CCG>CCA	p.P1730P	MAP1B_uc010iyw.1_Silent_p.P1747P|MAP1B_uc010iyx.1_Silent_p.P1604P|MAP1B_uc010iyy.1_Silent_p.P1604P	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1730						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AGGCCTCCCCGTCCACCTCTT	0.483													84	121					0	0	0	0	A	71494372	A	A	71494372	2	1	89	1	0	0	0	0	0	0	0	1	9281	1132	40	1		1	MAP1B	5	71494372	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08	63623444	71494372	109420888	40	17626											
PDE8B	8622	broad.mit.edu	37	chr5	76704787	76704787	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggaagccttggacagagttCtagagattttacggaccaca	12	9	11	9	2	1	2	0	0	1	2	1	6	1	5	2	3	2	1	2	3	3	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:76704787C>G	uc003kfa.2	+	14	1480	c.1435C>G	c.(1435-1437)CTA>GTA	p.L479V	PDE8B_uc003kfb.2_Missense_Mutation_p.L459V|PDE8B_uc003kfc.2_Intron|PDE8B_uc003kfd.2_Missense_Mutation_p.L432V|PDE8B_uc003kfe.2_Missense_Mutation_p.L382V	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	479					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GGACAGAGTTCTAGAGATTTT	0.463													12	38					0	0	0	0	G	76704787	G	G	76704787	3	3	89	1	0	0	0	0	1	0	0	0	11708	912	32	2	1489	2	PDE8B	5	76704787	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	5210415	76704787	104210473	41	17627											
PCDHB4	56131	broad.mit.edu	37	chr5	140503125	140503125	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacggccacctgttcgccctCaggtcgctggactacgaggc	7	7	12	15	4	1	0	1	0	0	0	3	2	1	1	3	4	2	2	3	4	2	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:140503125C>T	uc003lip.1	+	1	1545	c.1545C>T	c.(1543-1545)CTC>CTT	p.L515L		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	515	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTTCGCCCTCAGGTCGCTGG	0.697													52	121					0	0	0	0	T	140503125	T	T	140503125	2	4	89	1	0	0	0	0	0	0	0	1	11598	813	29	2		2	PCDHB4	5	140503125	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	63798338	140503125	40412135	42	17628											
PCDHGA2	56113	broad.mit.edu	37	chr5	140718650	140718650	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcgctattctgtgcgggaaGagatcgacagaggctccttc	8	11	12	10	3	1	2	0	0	1	2	5	5	2	3	1	2	1	2	1	2	2	4			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:140718650G>C	uc003ljk.1	+	1	297	c.112G>C	c.(112-114)GAG>CAG	p.E38Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.E38Q	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	38	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGCGGGAAGAGATCGACAG	0.597											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	57					0	0	0	0	C	140718650	C	C	140718650	3	2	89	1	0	0	0	0	1	0	0	0	11608	943	33	2	114	2	PCDHGA2	5	140718650	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	215525	140718650	40196610	43	17629											
TCERG1	10915	broad.mit.edu	37	chr5	145851118	145851118	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcaaagccagttgctactgCtcctattcctggtactccat	8	12	8	13	0	0	0	0	0	0	0	3	0	3	0	4	2	5	5	4	2	4	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:145851118C>T	uc003lob.2	+	9	1620	c.1580C>T	c.(1579-1581)GCT>GTT	p.A527V	TCERG1_uc003loc.2_Missense_Mutation_p.A506V|TCERG1_uc011dbt.1_Missense_Mutation_p.A506V	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	527					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTGCTACTGCTCCTATTCCT	0.303													16	38					0	0	0	0	T	145851118	T	T	145851118	3	4	89	1	0	0	0	0	1	0	0	0	15751	797	28	4	1614	4	TCERG1	5	145851118	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	5132468	145851118	35064142	44	17630											
PDGFRB	5159	broad.mit.edu	37	chr5	149514571	149514571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcattagggaggaagcccaCggtgggatctgccaggagtg	10	7	16	8	1	2	0	1	0	1	0	2	4	2	4	2	5	2	0	2	5	2	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:149514571C>T	uc003lro.2	-	4	842	c.373G>A	c.(373-375)GTG>ATG	p.V125M	PDGFRB_uc010jhd.2_Translation_Start_Site|PDGFRB_uc011dcg.1_Missense_Mutation_p.V125M	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	125	Extracellular (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGGAAGCCCACGGTGGGATCT	0.343			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								41	33					0	0	0	0	T	149514571	T	T	149514571	3	4	89	1	0	0	0	0	1	0	0	0	11716	536	19	1	3027	1	PDGFRB	5	149514571	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	3663453	149514571	31400689	45	17631											
HIST1H2AD	3013	broad.mit.edu	37	chr6	26199448	26199448	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttagctcgggcctttccGccttgcttgccgcgtccgga	2	11	12	16	5	0	0	0	0	0	0	3	1	2	1	6	2	3	2	6	2	1	4			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:26199448G>A	uc003ngw.2	-	1	24	c.24C>T	c.(22-24)GGC>GGT	p.G8G	HIST1H3D_uc003ngv.2_5'UTR|HIST1H2BF_uc003ngx.2_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	8					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.196)				GGGCCTTTCCGCCTTGCTTGC	0.507													12	29					0	0	0	0	A	26199448	A	A	26199448	2	1	89	1	0	0	0	0	0	0	0	1	7170	1074	38	1		1	HIST1H2AD	6	26199448	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08		26199448	144915619	46	17632											
HIST1H2AL	8332	broad.mit.edu	37	chr6	27833460	27833460	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcgctcagggtggtgtcctgCccaacatccaggctgtgcta	6	10	12	13	1	1	0	1	0	0	0	4	0	3	0	3	3	3	3	3	3	2	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:27833460C>A	uc003njw.2	+	1	354	c.328C>A	c.(328-330)CCC>ACC	p.P110T		NM_003511	NP_003502	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	110					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						TGGTGTCCTGCCCAACATCCA	0.552													64	98					1.53122e-18	1.80734e-18	1	0	A	27833460	A	A	27833460	3	1	89	1	0	0	0	0	1	0	0	0	7177	739	26	4	330	4	HIST1H2AL	6	27833460	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	1634012	27833460	143281607	47	17633											
PHF3	23469	broad.mit.edu	37	chr6	64422967	64422967	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taattttcccccacaaagcaTgtttggatttccaccacatt	11	14	4	12	0	0	0	0	0	0	0	2	1	2	1	4	1	1	2	4	1	2	6			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:64422967T>C	uc003pep.1	+	15	5509	c.5483T>C	c.(5482-5484)ATG>ACG	p.M1828T	PHF3_uc003pen.2_Missense_Mutation_p.M1740T|PHF3_uc011dxs.1_Missense_Mutation_p.M1097T	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1828	Pro-rich.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CCACAAAGCATGTTTGGATTT	0.512													91	128					0	0	0	0	C	64422967	C	C	64422967	3	2	89	1	0	0	0	0	1	0	0	0	11891	1464	51	5	5541	5	PHF3	6	64422967	Missense_Mutation	SNP	T	TCGA-CN-6998-01A-23D-2012-08	36589507	64422967	106692100	48	17634											
SOBP	55084	broad.mit.edu	37	chr6	107956339	107956339	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtcgcctgaggaaccggCggtgagcgagctagagtcgg	7	6	18	10	5	0	3	0	2	0	1	2	5	0	4	2	4	3	2	2	4	2	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:107956339C>T	uc003prx.2	+	6	2795	c.2291C>T	c.(2290-2292)GCG>GTG	p.A764V		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	764							metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GAGGAACCGGCGGTGAGCGAG	0.607													7	27					0	0	0	0	T	107956339	T	T	107956339	3	4	89	1	0	0	0	0	1	0	0	0	14976	768	27	1	2313	1	SOBP	6	107956339	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	43533372	107956339	63158728	49	17635											
SLC2A12	154091	broad.mit.edu	37	chr6	134350301	134350301	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttcatcaccagaaaccgaGggcttggaggaagaaaatac	15	7	10	9	1	2	2	2	0	0	2	2	5	2	4	2	3	2	1	2	3	5	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:134350301G>C	uc003qem.1	-	2	833	c.662C>G	c.(661-663)CCT>CGT	p.P221R		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	221	Cytoplasmic (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		CAGAAACCGAGGGCTTGGAGG	0.448													30	60					0	0	0	0	C	134350301	C	C	134350301	3	2	89	1	0	0	0	0	1	0	0	0	14605	1000	35	4	1207	4	SLC2A12	6	134350301	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	26393962	134350301	36764766	50	17636											
C6orf70	55780	broad.mit.edu	37	chr6	170156467	170156467	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatttgatgccttggaaagtCtacaatctcctgctatttct	9	17	6	9	0	3	1	0	1	3	0	4	2	3	2	2	1	3	1	2	1	5	6			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:170156467C>T	uc003qxg.1	+	4	382	c.349C>T	c.(349-351)CTA>TTA	p.L117L	C6orf70_uc011ehb.1_5'UTR|C6orf70_uc003qxh.1_Silent_p.L117L|C6orf70_uc010kky.1_5'UTR	NM_018341	NP_060811	Q5T6L9	CF070_HUMAN	hypothetical protein LOC55780	117						integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		CTTGGAAAGTCTACAATCTCC	0.348													9	48					0	0	0	0	T	170156467	T	T	170156467	2	4	89	1	0	0	0	0	0	0	0	1	2380	912	32	2		2	C6orf70	6	170156467	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	35806166	170156467	958600	51	17637											
INTS1	26173	broad.mit.edu	37	chr7	1517526	1517526	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagagaagaatgcagtcagCagctcctccaggtgggggga	11	5	16	9	0	1	2	1	0	0	2	3	4	3	3	2	4	3	4	2	4	2	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:1517526C>A	uc003skn.2	-	34	4778	c.4677G>T	c.(4675-4677)CTG>CTT	p.L1559L	INTS1_uc003skm.1_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1559					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		ATGCAGTCAGCAGCTCCTCCA	0.647													6	77					2.0095e-06	2.27849e-06	1	0	A	1517526	A	A	1517526	2	1	89	1	0	0	0	0	0	0	0	1	7814	697	25	4		4	INTS1	7	1517526	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08		1517526	157621137	52	17638											
CPVL	54504	broad.mit.edu	37	chr7	29105714	29105714	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggatcacttgttaagtcGccatctagtagtttatccag	11	13	9	8	1	2	0	1	0	1	0	4	2	3	1	2	1	0	3	2	1	5	6			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:29105714G>A	uc003szv.2	-	10	1007	c.888C>T	c.(886-888)GGC>GGT	p.G296G	CPVL_uc003szw.2_Silent_p.G296G|CPVL_uc003szx.2_Silent_p.G296G	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	296					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						TTGTTAAGTCGCCATCTAGTA	0.299													11	42					0	0	0	0	A	29105714	A	A	29105714	2	1	89	1	0	0	0	0	0	0	0	1	3850	1074	38	1		1	CPVL	7	29105714	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08	27588188	29105714	130032949	53	17639											
TSC22D4	81628	broad.mit.edu	37	chr7	100075277	100075277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caggccgaggctggccagctCcaacctggaatccaaagatc	11	5	11	14	1	0	1	0	0	0	1	3	3	2	2	5	4	2	2	5	4	3	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:100075277C>T	uc003uva.2	-	2	1140	c.385G>A	c.(385-387)GAG>AAG	p.E129K	TSC22D4_uc003uvb.2_Intron|TSC22D4_uc011kjv.1_Intron|TSC22D4_uc010lgx.2_Missense_Mutation_p.E129K|TSC22D4_uc003uvc.3_Missense_Mutation_p.E129K	NM_030935	NP_112197	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	129					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGGCCAGCTCCAACCTGGAA	0.692													7	6					0	0	0	0	T	100075277	T	T	100075277	3	4	89	1	0	0	0	0	1	0	0	0	16677	864	30	2	818	2	TSC22D4	7	100075277	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	70969563	100075277	59063386	54	17640											
SSPO	23145	broad.mit.edu	37	chr7	149486777	149486777	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgtgacggagtctgggactgCccagatggagccgatgaggg	8	7	18	8	2	1	3	0	2	1	1	1	7	1	6	2	4	2	0	2	4	0	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:149486777C>T	uc010lpk.2	+	31	4551	c.4551C>T	c.(4549-4551)TGC>TGT	p.C1517C		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1517	LDL-receptor class A 4.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCTGGGACTGCCCAGATGGAG	0.667													9	16					0	0	0	0	T	149486777	T	T	149486777	2	4	89	1	0	0	0	0	0	0	0	1	15255	747	26	4		4	SSPO	7	149486777	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	49411500	149486777	9651886	55	17641											
MLL3	58508	broad.mit.edu	37	chr7	151891214	151891214	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacatcttttccgccaagctCtaggagataaaacaataata	17	10	5	9	1	2	1	0	0	2	1	3	2	3	1	2	1	3	1	2	1	8	6			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:151891214C>G	uc003wla.2	-	31	4760	c.4541_splice	c.e31-1	p.E1514_splice	MLL3_uc003wkz.2_Splice_Site_p.E575_splice	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CCGCCAAGCTCTAGGAGATAA	0.418			N		medulloblastoma								10	27					0	0	0	0	G	151891214	G	G	151891214	5	3	89	1	0	0	0	0	0	0	1	0	9675	927	32	2	10311	2	MLL3	7	151891214	Splice_Site	SNP	C	TCGA-CN-6998-01A-23D-2012-08	2404437	151891214	7247449	56	17642											
ZFHX4	79776	broad.mit.edu	37	chr8	77618583	77618583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaccagcctcagtggctgcGgaacaccctctccgtccaaa	10	6	8	17	2	2	0	1	0	1	0	4	1	3	1	5	2	3	1	5	2	2	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr8:77618583G>A	uc003yav.2	+	2	2647	c.2260G>A	c.(2260-2262)GGA>AGA	p.G754R	ZFHX4_uc003yat.1_Missense_Mutation_p.G754R|ZFHX4_uc003yau.1_Missense_Mutation_p.G754R|ZFHX4_uc003yaw.1_Missense_Mutation_p.G754R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	754						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGTGGCTGCGGAACACCCTC	0.527										HNSCC(33;0.089)			25	19					0	0	0	0	A	77618583	A	A	77618583	3	1	89	1	0	0	0	0	1	0	0	0	17702	1117	39	1	2262	1	ZFHX4	8	77618583	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08		77618583	68745439	57	17643											
CNGB3	54714	broad.mit.edu	37	chr8	87638274	87638274	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcgagggctaactggacCgtagttggtagggtcttaag	9	10	16	6	2	1	0	0	0	1	0	1	2	1	1	1	5	1	4	1	5	4	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr8:87638274C>T	uc003ydx.2	-	13	1561	c.1515G>A	c.(1513-1515)ACG>ACA	p.T505T	CNGB3_uc010maj.2_Silent_p.T367T	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	505	Helical; Name=H6; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						CTAACTGGACCGTAGTTGGTA	0.383													20	42					0	0	0	0	T	87638274	T	T	87638274	2	4	89	1	0	0	0	0	0	0	0	1	3616	639	23	1		1	CNGB3	8	87638274	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	10019691	87638274	58725748	58	17644											
ZNF251	90987	broad.mit.edu	37	chr8	145948537	145948537	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagatctttccctgcccaCggtagcttctgttaaaactc	10	12	6	13	1	2	1	0	0	2	1	4	1	3	1	2	1	3	3	2	1	4	4			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr8:145948537C>T	uc003zdv.3	-	5	764	c.508G>A	c.(508-510)GTG>ATG	p.V170M		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TCCCTGCCCACGGTAGCTTCT	0.438													106	133					0	0	0	0	T	145948537	T	T	145948537	3	4	89	1	0	0	0	0	1	0	0	0	17863	536	19	1	1511	1	ZNF251	8	145948537	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	58310263	145948537	415485	59	17645											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			17	10					0	0	0	0	A	21971120	A	A	21971120	4	1	89	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08		21971120	119242311	60	17646											
TRPM6	140803	broad.mit.edu	37	chr9	77386695	77386695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatggaagtatttttccaCgcactgctcctcaaaatcat	11	13	5	12	1	3	0	3	0	0	0	5	1	5	1	2	1	1	3	2	1	4	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr9:77386695C>T	uc004ajl.1	-	25	3698	c.3460G>A	c.(3460-3462)GTG>ATG	p.V1154M	TRPM6_uc004ajk.1_Missense_Mutation_p.V1149M|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.V110M	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1154	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TATTTTTCCACGCACTGCTCC	0.353													8	45					0	0	0	0	T	77386695	T	T	77386695	3	4	89	1	0	0	0	0	1	0	0	0	16657	536	19	1	2668	1	TRPM6	9	77386695	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	55415575	77386695	63826736	61	17647											
C10orf140	387640	broad.mit.edu	37	chr10	21804522	21804522	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggatttaaggaaggagtttCtttttcagggcatgcaaaac	12	13	11	5	0	2	0	1	0	1	0	2	3	2	3	0	4	2	3	0	4	4	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr10:21804522C>G	uc009xkd.2	-	4	4483	c.2230G>C	c.(2230-2232)GAA>CAA	p.E744Q	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	663						nucleus	nucleotide binding			ovary(1)	1						GAAGGAGTTTCTTTTTCAGGG	0.453													80	152					0	0	0	0	G	21804522	G	G	21804522	3	3	89	1	0	0	0	0	1	0	0	0	1601	922	32	2	500	2	C10orf140	10	21804522	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08		21804522	113730225	62	17648											
NEUROG3	50674	broad.mit.edu	37	chr10	71332754	71332754	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggaaggaccgctccgtctCacgggtcacttggacagtgg	7	7	16	11	3	2	0	2	0	1	0	4	3	3	3	2	6	0	1	2	6	1	1	rs146974265		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr10:71332754C>T	uc001jpp.2	-	2	204	c.46G>A	c.(46-48)GAG>AAG	p.E16K		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	16					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						CGCTCCGTCTCACGGGTCACT	0.677													17	44					0	0	0	0	T	71332754	T	T	71332754	3	4	89	1	0	0	0	0	1	0	0	0	10408	835	29	2	602	2	NEUROG3	10	71332754	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	49528232	71332754	64201993	63	17649											
SORCS3	22986	broad.mit.edu	37	chr10	106982909	106982909	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcatctccgagttccatttGttgccataagaaataaggag	12	13	8	8	1	2	1	1	0	1	1	4	3	3	2	3	1	1	2	3	1	3	6			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr10:106982909G>A	uc001kyi.1	+	20	2997	c.2770G>A	c.(2770-2772)GTT>ATT	p.V924I	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	924	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGTTCCATTTGTTGCCATAAG	0.453													25	73					0	0	0	0	A	106982909	A	A	106982909	3	1	89	1	0	0	0	0	1	0	0	0	14996	1377	48	4	2848	4	SORCS3	10	106982909	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	35650155	106982909	28551838	64	17650											
SBF2	81846	broad.mit.edu	37	chr11	10022466	10022466	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagatgaatacttacaagttCatggacatcagttttaaaga	17	12	7	5	0	2	3	2	1	0	2	2	4	2	4	0	1	2	2	0	1	7	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:10022466C>G	uc001mib.2	-	8	994	c.856G>C	c.(856-858)GAA>CAA	p.E286Q	SBF2_uc001mif.3_Missense_Mutation_p.E42Q	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	286	DENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CTTACAAGTTCATGGACATCA	0.363													3	6					0	0	0	0	G	10022466	G	G	10022466	3	3	89	1	0	0	0	0	1	0	0	0	13924	835	29	2	4825	2	SBF2	11	10022466	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08		10022466	124984050	65	17651											
ABTB2	25841	broad.mit.edu	37	chr11	34194744	34194744	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaccaggcagcagcagcCgggctgcctgccggatgtcg	7	4	15	15	3	0	1	0	0	0	1	1	2	0	2	5	3	5	4	5	3	0	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:34194744C>T	uc001mvl.1	-	4	1027	c.797G>A	c.(796-798)CGG>CAG	p.R266Q		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	266							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				CAGCAGCAGCCGGGCTGCCTG	0.692													13	36					0	0	0	0	T	34194744	T	T	34194744	3	4	89	1	0	0	0	0	1	0	0	0	103	652	23	1	1778	1	ABTB2	11	34194744	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	24172278	34194744	100811772	66	17652											
TP53I11	9537	broad.mit.edu	37	chr11	44958408	44958408	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgctggtcacctgggctcCatcaaagaccgcatcataga	10	9	9	13	1	3	2	3	0	0	2	4	2	4	2	3	2	1	3	3	2	2	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:44958408C>T	uc001myi.2	-	8	885	c.280G>A	c.(280-282)GGA>AGA	p.G94R	TP53I11_uc001myf.1_RNA|TP53I11_uc001myj.2_Missense_Mutation_p.G94R|TP53I11_uc001myk.2_Missense_Mutation_p.G94R|TP53I11_uc001myl.2_Missense_Mutation_p.G94R|TP53I11_uc001mym.2_Missense_Mutation_p.G41R	NM_006034	NP_006025	O14683	P5I11_HUMAN	p53-induced protein	94	Extracellular (Potential).				negative regulation of cell proliferation|response to stress	integral to membrane				ovary(1)	1						ACCTGGGCTCCATCAAAGACC	0.687											OREG0020923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	26					0	0	0	0	T	44958408	T	T	44958408	3	4	89	1	0	0	0	0	1	0	0	0	16452	603	21	4	301	4	TP53I11	11	44958408	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	10763664	44958408	90048108	67	17653											
C11orf9	745	broad.mit.edu	37	chr11	61533490	61533490	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tactcccacgggcagcctgcGatgcctggctccagcggggt	5	7	14	15	3	0	0	0	0	0	0	2	1	2	0	4	4	5	2	4	4	1	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:61533490G>A	uc001nsc.1	+	3	291	c.195G>A	c.(193-195)GCG>GCA	p.A65A	C11orf9_uc001nse.1_Silent_p.A56A	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	65					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GGCAGCCTGCGATGCCTGGCT	0.746													5	13					0	0	0	0	A	61533490	A	A	61533490	2	1	89	1	0	0	0	0	0	0	0	1	1677	1045	37	1		1	C11orf9	11	61533490	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08	16575082	61533490	73473026	68	17654											
PCNXL3	399909	broad.mit.edu	37	chr11	65402839	65402839	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgccctccctgctggcgctgCgccatgtcctggatgatgcc	3	9	12	17	3	0	1	0	1	0	0	2	2	2	2	5	2	3	2	5	2	0	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:65402839C>T	uc001oey.2	+	31	5104	c.5104C>T	c.(5104-5106)CGC>TGC	p.R1702C	PCNXL3_uc001oez.2_Missense_Mutation_p.R589C	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1702						integral to membrane					0						GCTGGCGCTGCGCCATGTCCT	0.637													7	20					0	0	0	0	T	65402839	T	T	65402839	3	4	89	1	0	0	0	0	1	0	0	0	11647	768	27	1	5226	1	PCNXL3	11	65402839	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	3869349	65402839	69603677	69	17655											
GAB2	9846	broad.mit.edu	37	chr11	77937653	77937653	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctgcctgacttggcttgggGgggcggggtgggggagctat	3	10	21	7	1	1	1	0	1	1	0	1	2	1	2	1	8	2	2	1	8	1	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:77937653G>A	uc001ozh.2	-	4	1065	c.1065C>T	c.(1063-1065)CCC>CCT	p.P355P	GAB2_uc001ozg.2_Silent_p.P317P	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	355	SH3-binding.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TTGGCTTGGGGGGGCGGGGTG	0.582													24	53					0	0	0	0	A	77937653	A	A	77937653	2	1	89	1	0	0	0	0	0	0	0	1	6183	1219	43	4		4	GAB2	11	77937653	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08	12534814	77937653	57068863	70	17656											
EXPH5	23086	broad.mit.edu	37	chr11	108385369	108385369	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ataaattgtgcttgtcctagGagaaaaggttttaaaacctt	14	14	8	5	0	0	1	0	0	0	1	1	2	1	1	2	2	2	2	2	2	7	7			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:108385369G>C	uc001pkk.2	-	6	976	c.865C>G	c.(865-867)CCT>GCT	p.P289A	EXPH5_uc010rvy.1_Missense_Mutation_p.P101A|EXPH5_uc010rvz.1_Missense_Mutation_p.P133A|EXPH5_uc010rwa.1_Missense_Mutation_p.P213A	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	289					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTTGTCCTAGGAGAAAAGGTT	0.378													12	30					0	0	0	0	C	108385369	C	C	108385369	3	2	89	1	0	0	0	0	1	0	0	0	5347	1174	41	2	5108	2	EXPH5	11	108385369	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	30447716	108385369	26621147	71	17657											
CLEC2D	29121	broad.mit.edu	37	chr12	9840539	9840539	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagagccatcagtatgtcttCaagctgcatgcccagaaagc	13	8	9	11	0	3	2	2	0	1	2	3	2	3	2	2	0	5	3	2	0	4	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:9840539C>T	uc001qwg.1	+	3	236	c.214C>T	c.(214-216)CAA>TAA	p.Q72*	CLEC2D_uc001qwf.1_Nonsense_Mutation_p.Q72*|CLEC2D_uc009zgs.1_RNA|CLEC2D_uc001qwh.1_RNA|CLEC2D_uc009zgt.1_RNA|CLEC2D_uc009zgu.1_Nonsense_Mutation_p.Q30*	NM_013269	NP_037401	Q9UHP7	CLC2D_HUMAN	osteoclast inhibitory lectin isoform 1	72	Extracellular (Potential).				cell surface receptor linked signaling pathway	cell surface|endoplasmic reticulum|integral to plasma membrane|membrane fraction	sugar binding|transmembrane receptor activity				0						AGTATGTCTTCAAGCTGCATG	0.303													11	38					0	0	0	0	T	9840539	T	T	9840539	4	4	89	1	0	0	0	0	0	1	0	0	3523	827	29	2	224	2	CLEC2D	12	9840539	Nonsense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08		9840539	124011356	72	17658											
NAV3	89795	broad.mit.edu	37	chr12	78224975	78224976	+	5'Flank	INS	-	AG	AG																															agagagagagagagagagacINSagagagagagagagagagag																								rs77759134	by1000genomes	TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:78224975_78224976insAG	uc001syp.2	+						NAV3_uc001syo.2_5'Flank	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3							nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						gagagagagacagagagagaga	0.208										HNSCC(70;0.22)			---	---	---								AG	78224976	AG	AG	78224975	6	5	89	0	1	1	1	0	0	0	0	0	10238	493	17	0		0	NAV3	12	78224975	5'Flank	INS	-	TCGA-CN-6998-01A-23D-2012-08	68384436	78224975	55626920	73	17659											
ANO4	121601	broad.mit.edu	37	chr12	101491682	101491682	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaatgggtattataatggtGctaaagcagacctggaataa	16	10	10	5	0	0	1	0	0	0	1	0	2	0	2	1	3	2	3	1	3	8	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:101491682G>T	uc010svm.1	+	21	2537	c.1965G>T	c.(1963-1965)GTG>GTT	p.V655V	ANO4_uc001thw.2_Silent_p.V620V|ANO4_uc001thx.2_Silent_p.V655V|ANO4_uc001thy.2_Silent_p.V175V	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	655	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTATAATGgtgctaaagcaga	0.299										HNSCC(74;0.22)			25	60					3.1745e-13	3.68651e-13	1	0	T	101491682	T	T	101491682	2	4	89	1	0	0	0	0	0	0	0	1	699	1306	46	4		4	ANO4	12	101491682	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08	23266707	101491682	32360213	74	17660											
CIT	11113	broad.mit.edu	37	chr12	120172072	120172072	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctccaggcctcccactgccGctctttttctagcagctcat	5	12	6	18	1	3	0	1	0	2	0	5	0	5	0	5	1	3	3	5	1	1	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:120172072G>A	uc001txi.1	-	25	3174	c.3121C>T	c.(3121-3123)CGG>TGG	p.R1041W	CIT_uc001txh.1_Missense_Mutation_p.R575W|CIT_uc001txj.1_Missense_Mutation_p.R1083W	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1041	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TCCCACTGCCGCTCTTTTTCT	0.547													34	42					0	0	0	0	A	120172072	A	A	120172072	3	1	89	1	0	0	0	0	1	0	0	0	3453	1086	38	1	3054	1	CIT	12	120172072	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	18680390	120172072	13679823	75	17661											
UBC	7316	broad.mit.edu	37	chr12	125397196	125397196	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcccacctctgagacggagCaccaggtgcaaggtggactc	10	6	12	13	1	1	1	0	1	1	1	3	4	2	3	3	4	2	2	3	4	1	0	rs1136634		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:125397196C>T	uc001ugs.3	-	2	1570	c.1122G>A	c.(1120-1122)GTG>GTA	p.V374V	UBC_uc001ugr.2_Intron|UBC_uc001ugu.1_Silent_p.V374V|UBC_uc001ugt.2_Silent_p.V374V|UBC_uc001ugv.2_Intron	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	374	Ubiquitin-like 5.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGAGACGGAGCACCAGGTGCA	0.532													5	153					0	0	0	0	T	125397196	T	T	125397196	2	4	89	1	0	0	0	0	0	0	0	1	16910	697	25	4		4	UBC	12	125397196	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	5225124	125397196	8454699	76	17662											
JUB	84962	broad.mit.edu	37	chr14	23444255	23444255	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggatgccatccaggcacttgTtgcaaacaatgcatcggaaa	13	8	10	10	1	0	0	0	0	0	0	2	2	1	2	2	3	4	4	2	3	3	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:23444255T>A	uc001whz.2	-	5	1674	c.1298A>T	c.(1297-1299)AAC>ATC	p.N433I	JUB_uc001why.2_Missense_Mutation_p.N16I	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	433	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CAGGCACTTGTTGCAAACAAT	0.522													57	32					0	0	0	0	A	23444255	A	A	23444255	3	1	89	1	0	0	0	0	1	0	0	0	8007	1725	60	5	334	5	JUB	14	23444255	Missense_Mutation	SNP	T	TCGA-CN-6998-01A-23D-2012-08		23444255	83905285	77	17663											
MPP5	64398	broad.mit.edu	37	chr14	67779302	67779302	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgacccttatgttccatgtcGagagttaggtctgtcttttc	6	17	9	9	1	2	2	0	1	2	1	5	3	3	2	2	1	0	2	2	1	2	5	rs150659640		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:67779302G>A	uc001xjc.2	+	9	1566	c.1100G>A	c.(1099-1101)CGA>CAA	p.R367Q	MPP5_uc001xjd.2_Missense_Mutation_p.R333Q|ATP6V1D_uc001xje.2_Intron	NM_022474	NP_071919	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5	367	SH3.				tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			ovary(1)	1				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		GTTCCATGTCGAGAGTTAGGT	0.393													58	18					0	0	0	0	A	67779302	A	A	67779302	3	1	89	1	0	0	0	0	1	0	0	0	9790	1058	37	1	1126	1	MPP5	14	67779302	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	44335047	67779302	39570238	78	17664											
KIAA1409	57578	broad.mit.edu	37	chr14	94088226	94088226	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgaccctggacgttctagAcagaactctgctacgaggcc	11	7	10	13	3	2	2	0	0	2	2	2	5	2	3	2	2	4	2	2	2	4	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:94088226A>G	uc001ybv.1	+	28	4265	c.4182A>G	c.(4180-4182)AGA>AGG	p.R1394R	KIAA1409_uc001ybs.1_Silent_p.R1372R	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1549						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GACGTTCTAGACAGAACTCTG	0.512													68	33					0	0	0	0	G	94088226	G	G	94088226	2	3	89	1	0	0	0	0	0	0	0	1	8269	272	10	5		5	KIAA1409	14	94088226	Silent	SNP	A	TCGA-CN-6998-01A-23D-2012-08	26308924	94088226	13261314	79	17665											
PACS2	23241	broad.mit.edu	37	chr14	105849787	105849787	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccatcctgcggctctttgtgGagcagctgtcccacaagaca	8	9	10	14	1	1	1	0	0	1	1	3	2	3	2	3	2	3	3	3	2	1	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:105849787G>A	uc001yqt.2	+	16	1880	c.1705G>A	c.(1705-1707)GAG>AAG	p.E569K	PACS2_uc001yqs.2_Missense_Mutation_p.E494K|PACS2_uc001yqv.2_Missense_Mutation_p.E573K|PACS2_uc001yqu.2_Missense_Mutation_p.E573K	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	569					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GCTCTTTGTGGAGCAGCTGTC	0.642													47	16					0	0	0	0	A	105849787	A	A	105849787	3	1	89	1	0	0	0	0	1	0	0	0	11427	1175	41	2	1779	2	PACS2	14	105849787	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	11761561	105849787	1499753	80	17666											
GABRA5	2558	broad.mit.edu	37	chr15	27188544	27188544	+	Frame_Shift_Del	DEL	A	-	-																															gaggctgggcctgggatggcAaaaaagccttggaagcagcc																										TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr15:27188544delA	uc001zbd.1	+	11	1399	c.1060delA	c.(1060-1062)AAAfs	p.K354fs	GABRA5_uc001zbe.1_5'Flank	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	354	Cytoplasmic (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTGGGATGGCAAAAAAGCCTT	0.498													---	---	---								-	27188544	-	-	27188544	7	5	89	1	0	1	0	1	0	0	0	0	6198	131	5	0	1090	0	GABRA5	15	27188544	Frame_Shift_Del	DEL	A	TCGA-CN-6998-01A-23D-2012-08		27188544	75342848	81	17667											
SALL1	6299	broad.mit.edu	37	chr16	51174768	51174768	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtcactcccaaagaccttCgcgcagaacctgcacttgtg	9	9	8	15	2	1	2	1	0	0	2	3	2	2	2	3	0	2	2	3	0	2	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:51174768C>T	uc010vgs.1	-	2	1396	c.1365G>A	c.(1363-1365)GCG>GCA	p.A455A	SALL1_uc010vgr.1_Silent_p.A358A|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	455	C2H2-type 1.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CAAAGACCTTCGCGCAGAACC	0.512													47	59					0	0	0	0	T	51174768	T	T	51174768	2	4	89	1	0	0	0	0	0	0	0	1	13875	871	31	1		1	SALL1	16	51174768	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08		51174768	39179985	82	17668											
ELMO3	79767	broad.mit.edu	37	chr16	67235652	67235652	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acactgaccccaggagcagcGggagcagctgcaggtcctac	10	4	13	14	1	0	1	0	1	0	0	1	3	1	3	3	3	6	4	3	3	1	1			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:67235652G>A	uc002esa.2	+	11	1128	c.1085G>A	c.(1084-1086)CGG>CAG	p.R362Q	ELMO3_uc002esb.2_Missense_Mutation_p.R345Q|ELMO3_uc002esc.2_Missense_Mutation_p.R196Q	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	309	ELMO.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		CAGGAGCAGCGGGAGCAGCTG	0.637													17	37					0	0	0	0	A	67235652	A	A	67235652	3	1	89	1	0	0	0	0	1	0	0	0	5091	1116	39	1	1127	1	ELMO3	16	67235652	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	16060884	67235652	23119101	83	17669											
PLEKHG4	25894	broad.mit.edu	37	chr16	67315718	67315718	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcctgccttactgccaccAggcctggctggatttccgaa	7	9	11	14	1	0	0	0	0	0	0	1	2	1	1	6	4	3	1	6	4	2	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:67315718A>G	uc002eso.3	+	6	3518	c.983A>G	c.(982-984)CAG>CGG	p.Q328R	PLEKHG4_uc002esp.3_Missense_Mutation_p.Q135R|PLEKHG4_uc002esq.3_Missense_Mutation_p.Q328R|PLEKHG4_uc010cef.2_Missense_Mutation_p.Q328R|PLEKHG4_uc002ess.3_Missense_Mutation_p.Q328R|PLEKHG4_uc010ceg.2_Missense_Mutation_p.Q247R	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	328					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		TACTGCCACCAGGCCTGGCTG	0.617													4	104					0	0	0	0	G	67315718	G	G	67315718	3	3	89	1	0	0	0	0	1	0	0	0	12126	188	7	5	1005	5	PLEKHG4	16	67315718	Missense_Mutation	SNP	A	TCGA-CN-6998-01A-23D-2012-08	80066	67315718	23039035	84	17670											
OR1A2	26189	broad.mit.edu	37	chr17	3101020	3101020	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgccaacctctccttggttGacatcatcttctcatccgta	7	15	5	14	1	4	1	2	1	3	0	7	1	5	1	4	1	2	2	4	1	2	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:3101020G>A	uc002fvd.1	+	1	208	c.208G>A	c.(208-210)GAC>AAC	p.D70N		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CTCCTTGGTTGACATCATCTT	0.483													85	112					0	0	0	0	A	3101020	A	A	3101020	3	1	89	1	0	0	0	0	1	0	0	0	11004	1290	45	2	210	2	OR1A2	17	3101020	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08		3101020	78094190	85	17671											
TP53	7157	broad.mit.edu	37	chr17	7577022	7577022	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtcctgcttgcttacctcGcttagtgctccctgggggca	3	14	11	13	1	0	0	0	0	0	0	3	0	2	0	3	2	4	5	3	2	2	4	rs121913344		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:7577022G>A	uc002gim.2	-	8	1110	c.916C>T	c.(916-918)CGA>TGA	p.R306*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.R306*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R174*|TP53_uc010cng.1_Nonsense_Mutation_p.R174*|TP53_uc002gii.1_Nonsense_Mutation_p.R174*|TP53_uc010cnh.1_Nonsense_Mutation_p.R306*|TP53_uc010cni.1_Nonsense_Mutation_p.R306*|TP53_uc002gij.2_Nonsense_Mutation_p.R306*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	306	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		R -> Q (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(99)|p.0?(7)|p.?(3)|p.R306R(2)|p.R306fs*39(2)|p.K305fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTACCTCGCTTAGTGCTC	0.562	R306*(MFE296_ENDOMETRIUM)|R306*(HCC1937_BREAST)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			53	31					0	0	0	0	A	7577022	A	A	7577022	4	1	89	1	0	0	0	0	0	1	0	0	16448	1095	38	1	370	1	TP53	17	7577022	Nonsense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	4476002	7577022	73618188	86	17672											
MYO15A	51168	broad.mit.edu	37	chr17	18022714	18022714	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagcatctacgcgtcaggCgagcccctgggcttcctgcc	5	7	12	17	4	2	0	1	0	1	0	3	1	3	0	4	2	4	3	4	2	1	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:18022714C>T	uc010vxh.1	+	2	938	c.600C>T	c.(598-600)GGC>GGT	p.G200G		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	200	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					ACGCGTCAGGCGAGCCCCTGG	0.706													12	41					0	0	0	0	T	18022714	T	T	18022714	2	4	89	1	0	0	0	0	0	0	0	1	10116	755	27	1		1	MYO15A	17	18022714	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	10445692	18022714	63172496	87	17673											
VPS25	84313	broad.mit.edu	37	chr17	40925516	40925516	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgatgagtttcgagtggcCgtggcagtatcgcttcccac	6	10	14	11	4	0	1	0	1	0	0	3	3	1	1	2	3	0	4	2	3	1	3	rs141909224		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:40925516C>T	uc002ibi.2	+	1	63	c.23C>T	c.(22-24)CCG>CTG	p.P8L		NM_032353	NP_115729	Q9BRG1	VPS25_HUMAN	vacuolar protein sorting 25	8					cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endosome membrane|nucleoplasm					0		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		TTCGAGTGGCCGTGGCAGTAT	0.632													26	123					0	0	0	0	T	40925516	T	T	40925516	3	4	89	1	0	0	0	0	1	0	0	0	17264	652	23	1	25	1	VPS25	17	40925516	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	22902802	40925516	40269694	88	17674											
MPO	4353	broad.mit.edu	37	chr17	56352927	56352927	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	accatggcccccacgatcttCcgggcttcctggtagagcct	6	9	10	16	2	1	1	0	0	1	1	3	2	3	1	6	3	1	2	6	3	1	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:56352927C>T	uc002ivu.1	-	8	1518	c.1341G>A	c.(1339-1341)CGG>CGA	p.R447R		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	447			R -> Q (in a colorectal cancer sample; somatic mutation).		anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity	p.R447Q(1)		ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CCACGATCTTCCGGGCTTCCT	0.438													14	44					0	0	0	0	T	56352927	T	T	56352927	2	4	89	1	0	0	0	0	0	0	0	1	9785	842	30	2		2	MPO	17	56352927	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	15427411	56352927	24842283	89	17675											
KIAA0195	9772	broad.mit.edu	37	chr17	73487507	73487507	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaggacctcaccgatggcCtatccacccgctccttctgc	7	9	8	17	2	2	1	1	1	1	0	4	3	4	2	6	2	1	1	6	2	1	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:73487507C>A	uc002jnz.3	+	13	1632	c.1357C>A	c.(1357-1359)CTA>ATA	p.L453I	KIAA0195_uc010wsa.1_Missense_Mutation_p.L463I|KIAA0195_uc010wsb.1_Missense_Mutation_p.L105I	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	453					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CACCGATGGCCTATCCACCCG	0.637													37	69					7.63091e-17	8.93375e-17	1	0	A	73487507	A	A	73487507	3	1	89	1	0	0	0	0	1	0	0	0	8199	680	24	4	1403	4	KIAA0195	17	73487507	Missense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08	17134580	73487507	7707703	90	17676											
SAFB	6294	broad.mit.edu	37	chr19	5641946	5641946	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagagcttccggagcagcttCaggaacatgctgtaggtaac	12	8	12	9	1	1	1	1	0	0	1	2	3	2	3	1	3	6	6	1	3	4	4			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:5641946C>T	uc002mcf.2	+	4	588	c.535C>T	c.(535-537)CAG>TAG	p.Q179*	SAFB_uc010xiq.1_Nonsense_Mutation_p.Q179*|SAFB_uc002mcg.2_Nonsense_Mutation_p.Q179*|SAFB_uc002mce.3_Nonsense_Mutation_p.Q179*|SAFB_uc010xir.1_Nonsense_Mutation_p.Q179*|SAFB_uc010xis.1_Intron|SAFB_uc010xit.1_Intron|SAFB_uc010xiu.1_Intron	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	179					chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		GGAGCAGCTTCAGGAACATGC	0.458													27	27					0	0	0	0	T	5641946	T	T	5641946	4	4	89	1	0	0	0	0	0	1	0	0	13871	827	29	2	549	2	SAFB	19	5641946	Nonsense_Mutation	SNP	C	TCGA-CN-6998-01A-23D-2012-08		5641946	53487037	91	17677											
AKT2	208	broad.mit.edu	37	chr19	40741920	40741920	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcgctcgtggtcctggttgTagaagggcaggcggccgcac	5	7	18	11	4	0	1	0	0	0	1	2	1	1	1	2	6	0	5	2	6	2	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:40741920T>C	uc002onf.2	-	11	1314	c.1052A>G	c.(1051-1053)TAC>TGC	p.Y351C	AKT2_uc010egs.2_Missense_Mutation_p.Y308C|AKT2_uc010egt.2_Missense_Mutation_p.Y289C|AKT2_uc010xvj.1_Missense_Mutation_p.Y289C|AKT2_uc010egu.1_Missense_Mutation_p.Y289C|AKT2_uc002one.2_Missense_Mutation_p.Y247C	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	351	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)			GTCCTGGTTGTAGAAGGGCAG	0.637			A		ovarian|pancreatic 								12	63					0	0	0	0	C	40741920	C	C	40741920	3	2	89	1	0	0	0	0	1	0	0	0	480	1638	57	5	409	5	AKT2	19	40741920	Missense_Mutation	SNP	T	TCGA-CN-6998-01A-23D-2012-08	35099974	40741920	18387063	92	17678											
IRGC	56269	broad.mit.edu	37	chr19	44223073	44223073	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccggctctccaggctgcccGgctgacaagtacctaaagca	9	6	11	15	2	1	1	0	1	1	0	2	1	1	1	4	3	3	5	4	3	4	2			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:44223073G>A	uc002oxh.2	+	2	510	c.363G>A	c.(361-363)CCG>CCA	p.P121P		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	121						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CAGGCTGCCCGGCTGACAAGT	0.657													7	32					0	0	0	0	A	44223073	A	A	44223073	2	1	89	1	0	0	0	0	0	0	0	1	7877	1103	39	1		1	IRGC	19	44223073	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08	3481153	44223073	14905910	93	17679											
OPA3	80207	broad.mit.edu	37	chr19	46056884	46056884	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagggcgccctgtggcggcGccgcctgcacctgcgcctgc	2	5	15	19	5	0	0	0	0	0	0	0	0	0	0	6	3	3	1	6	3	0	0			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:46056884G>A	uc002pck.3	-	2	528	c.428C>T	c.(427-429)GCG>GTG	p.A143V	OPA3_uc002pcj.3_Intron|OPA3_uc010xxk.1_Missense_Mutation_p.A90V	NM_025136	NP_079412	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform b	143	Potential.				response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		CTGTGGCGGCGCCGCCTGCAC	0.726													7	41					0	0	0	0	A	46056884	A	A	46056884	3	1	89	1	0	0	0	0	1	0	0	0	10926	1087	38	1	520	1	OPA3	19	46056884	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	1833811	46056884	13072099	94	17680											
SIGLEC10	89790	broad.mit.edu	37	chr19	51914354	51914354	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctaaagcctaagagaccctCattggaacttgacttctgca	12	10	7	12	0	2	2	1	1	1	1	2	4	2	3	3	1	3	1	3	1	4	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:51914354C>T	uc002pwo.2	-	11	2709	c.2093G>A	c.(2092-2094)TGA>TAA	p.*698*	SIGLEC10_uc002pwp.2_Silent_p.*640*|SIGLEC10_uc002pwq.2_Silent_p.*545*|SIGLEC10_uc002pwr.2_Silent_p.*603*|SIGLEC10_uc010ycy.1_Silent_p.*513*|SIGLEC10_uc010ycz.1_Silent_p.*555*|SIGLEC10_uc010eow.2_Silent_p.*415*	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	698					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AAGAGACCCTCATTGGAACTT	0.502													61	38					0	0	0	0	T	51914354	T	T	51914354	2	4	89	1	0	0	0	0	0	0	0	1	14371	837	29	2		2	SIGLEC10	19	51914354	Silent	SNP	C	TCGA-CN-6998-01A-23D-2012-08	5857470	51914354	7214629	95	17681											
PLCB4	5332	broad.mit.edu	37	chr20	9360788	9360788	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcattgagatgtatgaacctGatgaagatttgaagaaaaaa	18	11	9	3	0	1	7	1	5	0	3	1	8	1	7	1	0	1	1	1	0	7	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:9360788G>C	uc002wnf.2	+	12	968	c.832G>C	c.(832-834)GAT>CAT	p.D278H	PLCB4_uc010gbw.1_Missense_Mutation_p.D278H|PLCB4_uc010gbx.2_Missense_Mutation_p.D278H|PLCB4_uc002wne.2_Missense_Mutation_p.D278H|PLCB4_uc002wnh.2_Missense_Mutation_p.D125H	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	278					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						GTATGAACCTGATGAAGATTT	0.294													8	24					0	0	0	0	C	9360788	C	C	9360788	3	2	89	1	0	0	0	0	1	0	0	0	12085	1290	45	2	870	2	PLCB4	20	9360788	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08		9360788	53664732	96	17682											
KIF16B	55614	broad.mit.edu	37	chr20	16360188	16360188	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgaagaaacgcagttgagccTtttctaactcctcgccatct	10	11	7	13	3	2	2	0	1	2	1	4	3	3	2	3	0	3	2	3	0	3	4			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:16360188T>C	uc002wpg.1	-	19	2617	c.2459A>G	c.(2458-2460)AAG>AGG	p.K820R	KIF16B_uc002wpe.1_Missense_Mutation_p.K202R|KIF16B_uc002wpf.1_Missense_Mutation_p.K202R|KIF16B_uc010gch.1_Missense_Mutation_p.K820R|KIF16B_uc010gci.1_Missense_Mutation_p.K820R|KIF16B_uc010gcj.1_Missense_Mutation_p.K831R	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	820	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CAGTTGAGCCTTTTCTAACTC	0.517													3	87					0	0	0	0	C	16360188	C	C	16360188	3	2	89	1	0	0	0	0	1	0	0	0	8317	1609	56	5	1526	5	KIF16B	20	16360188	Missense_Mutation	SNP	T	TCGA-CN-6998-01A-23D-2012-08	6999400	16360188	46665332	97	17683											
BCL2L1	598	broad.mit.edu	37	chr20	30309591	30309591	+	Frame_Shift_Del	DEL	A	-	-																															acagtgccccgccgaaggagAaaaaggccacaatgcgaccc																										TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:30309591delA	uc002wwl.2	-	2	797	c.431delT	c.(430-432)TTCfs	p.F144fs	BCL2L1_uc002wwk.2_RNA|BCL2L1_uc002wwm.2_Intron|BCL2L1_uc002wwn.2_Frame_Shift_Del_p.F144fs|BCL2L1_uc002wwo.1_Frame_Shift_Del_p.F144fs	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	BCL2-like 1 isoform 1	144	BH1.				induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			lung(1)|central_nervous_system(1)	2	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			GCCGAAGGAGAAAAAGGCCAC	0.542													---	---	---								-	30309591	-	-	30309591	7	5	89	1	0	1	0	1	0	0	0	0	1369	246	9	0	278	0	BCL2L1	20	30309591	Frame_Shift_Del	DEL	A	TCGA-CN-6998-01A-23D-2012-08	13949403	30309591	32715929	98	17684											
TAF4	6874	broad.mit.edu	37	chr20	60584189	60584189	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaagccagttttattaacgtAgataggaaatttttacattt	14	16	7	4	1	0	1	0	0	0	1	0	3	0	2	1	1	3	2	1	1	7	9			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:60584189A>T	uc002ybs.2	-	5	1803	c.1803T>A	c.(1801-1803)TCT>TCA	p.S601S		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	601	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TTATTAACGTAGATAGGAAAT	0.353													19	49					0	0	0	0	T	60584189	T	T	60584189	2	4	89	1	0	0	0	0	0	0	0	1	15592	407	15	5		5	TAF4	20	60584189	Silent	SNP	A	TCGA-CN-6998-01A-23D-2012-08	30274598	60584189	2441331	99	17685											
DMD	1756	broad.mit.edu	37	chrX	32591889	32591889	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagtaagacgttgccatttGagaaggatgtcttgtaaaag	13	12	11	5	1	2	2	1	1	1	2	2	4	2	3	1	1	1	3	1	1	4	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chrX:32591889G>C	uc004dda.1	-	14	1921	c.1677C>G	c.(1675-1677)CTC>CTG	p.L559L	DMD_uc004dcz.2_Silent_p.L436L|DMD_uc004dcy.1_Silent_p.L555L|DMD_uc004ddb.1_Silent_p.L551L|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Silent_p.L551L|DMD_uc010ngp.1_Nonsense_Mutation_p.S79*|DMD_uc010ngq.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	559	Spectrin 3.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GTTGCCATTTGAGAAGGATGT	0.423													7	6					0	0	0	0	C	32591889	C	C	32591889	2	2	89	1	0	0	0	0	0	0	0	1	4602	1277	45	2		2	DMD	23	32591889	Silent	SNP	G	TCGA-CN-6998-01A-23D-2012-08		32591889	122678671	100	17686											
MID2	11043	broad.mit.edu	37	chrX	107159287	107159287	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccagacatcaattttaatGatgcctttgaaaactttgct	12	16	5	8	0	1	3	1	2	0	1	2	3	2	3	2	0	3	1	2	0	4	5			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chrX:107159287G>C	uc004enl.2	+	6	1702	c.1129G>C	c.(1129-1131)GAT>CAT	p.D377H	MID2_uc004enk.2_Missense_Mutation_p.D377H	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	377	COS.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						CAATTTTAATGATGCCTTTGA	0.353													33	14					0	0	0	0	C	107159287	C	C	107159287	3	2	89	1	0	0	0	0	1	0	0	0	9631	1290	45	2	1151	2	MID2	23	107159287	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	74567398	107159287	48111273	101	17687											
USP26	83844	broad.mit.edu	37	chrX	132161099	132161099	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagtgagctaaaaactcatGagcatcgttctgtgcattgc	12	11	9	9	1	2	2	1	2	1	0	3	2	2	2	0	0	5	4	0	0	3	3			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chrX:132161099G>C	uc010nrm.1	-	6	1620	c.1150C>G	c.(1150-1152)CAT>GAT	p.H384D	USP26_uc011mvf.1_Missense_Mutation_p.H384D	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	384					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					AAAAACTCATGAGCATCGTTC	0.358													24	14					0	0	0	0	C	132161099	C	C	132161099	3	2	89	1	0	0	0	0	1	0	0	0	17125	1290	45	2	1594	2	USP26	23	132161099	Missense_Mutation	SNP	G	TCGA-CN-6998-01A-23D-2012-08	25001812	132161099	23109461	102	17688											
TMEM39B	55116	broad.mit.edu	37	chr1	32542834	32542834	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcactcgcttcaccgttctcAcggcaacaggctggagtctg	7	10	10	14	3	4	0	3	0	2	0	6	1	4	1	1	3	1	4	1	3	1	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:32542834A>G	uc010ogv.1	+	5	651	c.505A>G	c.(505-507)ACG>GCG	p.T169A	TMEM39B_uc010ogt.1_Intron|TMEM39B_uc010ogu.1_Missense_Mutation_p.T42A|TMEM39B_uc001bue.3_Missense_Mutation_p.T169A|TMEM39B_uc001buf.3_Intron|TMEM39B_uc010ogw.1_Intron	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	169	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CACCGTTCTCACGGCAACAGG	0.597													4	99					0	0	0	0	G	32542834	G	G	32542834	3	3	90	1	0	0	0	0	1	0	0	0	16228	159	6	5	523	5	TMEM39B	1	32542834	Missense_Mutation	SNP	A	TCGA-CQ-5323-01A-01D-1683-08		32542834	216707787	1	17689											
MARCKSL1	65108	broad.mit.edu	37	chr1	32800482	32800482	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atttctcttgaaggacaggcCgctcaatttgaaaggcttct	10	13	9	9	1	3	2	1	2	2	0	4	3	3	3	1	3	0	2	1	3	3	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:32800482C>T	uc001bvd.2	-	2	504	c.304G>A	c.(304-306)GGC>AGC	p.G102S		NM_023009	NP_075385	P49006	MRP_HUMAN	MARCKS-like 1	102						plasma membrane	calmodulin binding			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				AAGGACAGGCCGCTCAATTTG	0.577													3	54					0	0	0	0	T	32800482	T	T	32800482	3	4	90	1	0	0	0	0	1	0	0	0	9363	652	23	1	287	1	MARCKSL1	1	32800482	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	257648	32800482	216450139	2	17690											
GRIK3	2899	broad.mit.edu	37	chr1	37337839	37337839	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgcagtcgaagataatgcGgaattcccggcctcgcttca	9	9	11	12	4	1	1	1	0	0	1	4	3	2	2	2	2	2	3	2	2	3	3	rs141595955		TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:37337839G>A	uc001caz.2	-	4	817	c.682C>T	c.(682-684)CGC>TGC	p.R228C	GRIK3_uc001cba.1_Missense_Mutation_p.R228C	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	228	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AAGATAATGCGGAATTCCCGG	0.597													14	23					0	0	0	0	A	37337839	A	A	37337839	3	1	90	1	0	0	0	0	1	0	0	0	6814	1116	39	1	2129	1	GRIK3	1	37337839	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	4537357	37337839	211912782	3	17691											
RD3	343035	broad.mit.edu	37	chr1	211652474	211652474	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcggagatggtcctgatgtcGctggcgaagggcgagatgcg	7	8	18	8	5	0	3	0	1	0	2	3	6	1	3	1	4	1	1	1	4	1	0			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:211652474G>A	uc001him.2	-	3	1656	c.492C>T	c.(490-492)AGC>AGT	p.S164S	RD3_uc001hin.2_RNA|RD3_uc009xda.2_RNA	NM_183059	NP_898882	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	164					response to stimulus|visual perception					ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		TCCTGATGTCGCTGGCGAAGG	0.701													9	13					0	0	0	0	A	211652474	A	A	211652474	2	1	90	1	0	0	0	0	0	0	0	1	13252	1078	38	1		1	RD3	1	211652474	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	174314635	211652474	37598147	4	17692											
DISC1	27185	broad.mit.edu	37	chr1	232162197	232162197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggaatcttacatcctttCtgcagaacttggagaaaagt	13	11	8	9	0	2	2	0	0	2	2	3	4	3	3	2	2	3	1	2	2	5	3			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr1:232162197C>T	uc001huz.2	+	12	2377	c.2324C>T	c.(2323-2325)TCT>TTT	p.S775F	TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pxh.1_Missense_Mutation_p.S807F|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_Missense_Mutation_p.S398F|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.S653F|DISC1_uc010pxn.1_Missense_Mutation_p.S420F|DISC1_uc001hva.2_Missense_Mutation_p.S753F	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	775	Necessary and sufficient for interaction with PCNT and localization at the centrosome.|Interaction with ATF4 and ATF5.|Interaction with PAFAH1B1.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				TACATCCTTTCTGCAGAACTT	0.443													4	6					0	0	0	0	T	232162197	T	T	232162197	3	4	90	1	0	0	0	0	1	0	0	0	4560	913	32	2	3211	2	DISC1	1	232162197	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	20509723	232162197	17088424	5	17693											
GCKR	2646	broad.mit.edu	37	chr2	27728586	27728586	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgtcttcacctcttcagcCcgagggtctcagcggctcct	4	11	11	15	2	5	0	3	0	3	0	7	1	6	0	3	3	2	1	3	3	0	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr2:27728586C>T	uc002rky.2	+	10	818	c.752C>T	c.(751-753)CCC>CTC	p.P251L	GCKR_uc010ezd.2_Missense_Mutation_p.P251L|GCKR_uc010ylu.1_Missense_Mutation_p.P61L	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	251	SIS 1.			P -> V (in Ref. 2; CAB61828).	carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					CCTCTTCAGCCCGAGGGTCTC	0.552													8	54					0	0	0	0	T	27728586	T	T	27728586	3	4	90	1	0	0	0	0	1	0	0	0	6329	637	22	4	790	4	GCKR	2	27728586	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08		27728586	215470787	6	17694											
DPP10	57628	broad.mit.edu	37	chr2	116534856	116534856	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgataaagatcttggcatacGatgaaactactcaaaaaatg	18	10	7	6	1	2	3	1	2	1	1	2	4	2	3	0	1	3	1	0	1	8	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr2:116534856G>A	uc002tla.1	+	14	1751	c.1294G>A	c.(1294-1296)GAT>AAT	p.D432N	DPP10_uc002tlb.1_Missense_Mutation_p.D382N|DPP10_uc002tlc.1_Missense_Mutation_p.D428N|DPP10_uc002tle.2_Missense_Mutation_p.D436N|DPP10_uc002tlf.1_Missense_Mutation_p.D425N	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	432	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CTTGGCATACGATGAAACTAC	0.358													9	36					0	0	0	0	A	116534856	A	A	116534856	3	1	90	1	0	0	0	0	1	0	0	0	4749	1058	37	1	1519	1	DPP10	2	116534856	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	88806270	116534856	126664517	7	17695											
GPR17	2840	broad.mit.edu	37	chr2	128409269	128409270	+	Frame_Shift_Ins	INS	-	C	C																															gcaaaaggctcaagggcccgINSccccccagcttcgaagggaa																										TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr2:128409269_128409270insC	uc010yzn.1	+	4	1655_1656	c.1044_1045insC	c.(1042-1047)CCGCCCfs	p.P348fs	LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Frame_Shift_Ins_p.P348fs|GPR17_uc010yzo.1_Frame_Shift_Ins_p.P320fs|GPR17_uc002tpd.2_Frame_Shift_Ins_p.P320fs	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	348_349	Cytoplasmic (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		TCAAGGGCCCGCCCCCCAGCTT	0.619													---	---	---								C	128409270	C	C	128409269	7	5	90	1	0	1	1	0	0	0	0	0	6705	1074	38	0	1050	0	GPR17	2	128409269	Frame_Shift_Ins	INS	-	TCGA-CQ-5323-01A-01D-1683-08	11874413	128409269	114790104	8	17696											
PDE11A	50940	broad.mit.edu	37	chr2	178682613	178682613	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcgttgatctgcatcatcaAaaggtttcccatcaagtctg	10	13	8	10	1	5	1	3	1	2	0	7	1	6	1	1	1	1	3	1	1	3	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr2:178682613A>G	uc002ulq.2	-	8	1934	c.1616T>C	c.(1615-1617)TTT>TCT	p.F539S	PDE11A_uc002ulp.2_Missense_Mutation_p.F95S|PDE11A_uc002ulr.2_Missense_Mutation_p.F289S|PDE11A_uc002uls.1_Missense_Mutation_p.F181S|PDE11A_uc002ult.1_Missense_Mutation_p.F289S|PDE11A_uc002ulu.1_Missense_Mutation_p.F181S	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	539	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TGCATCATCAAAAGGTTTCCC	0.378									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				5	34					0	0	0	0	G	178682613	G	G	178682613	3	3	90	1	0	0	0	0	1	0	0	0	11685	14	1	5	1237	5	PDE11A	2	178682613	Missense_Mutation	SNP	A	TCGA-CQ-5323-01A-01D-1683-08	50273344	178682613	64516760	9	17697											
BOLL	66037	broad.mit.edu	37	chr2	198636708	198636708	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctggcattatactagaaccTaaagcaaagattaaataata	19	10	6	6	0	0	2	0	0	0	2	0	2	0	2	1	1	3	3	1	1	11	7			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr2:198636708T>G	uc002uus.2	-	6	663	c.353_splice	c.e6-1	p.R118_splice	uc002uup.2_Intron|BOLL_uc002uur.2_Splice_Site_p.R124_splice|BOLL_uc002uut.2_Splice_Site_p.R130_splice|BOLL_uc010zha.1_Splice_Site_p.G9_splice|BOLL_uc002uuu.1_Splice_Site_p.R124_splice	NM_033030	NP_149019	Q8N9W6	BOLL_HUMAN	boule isoform 2						cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2						TACTAGAACCTAAAGCAAAGA	0.279													16	87					0	0	0	0	G	198636708	G	G	198636708	5	3	90	1	0	0	0	0	0	0	1	0	1492	1536	53	5	524	5	BOLL	2	198636708	Splice_Site	SNP	T	TCGA-CQ-5323-01A-01D-1683-08	19954095	198636708	44562665	10	17698											
MYRIP	25924	broad.mit.edu	37	chr3	40085595	40085595	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagtgcagcatcctctcgaaGcaccagcagtttgtggagca	11	8	11	11	1	1	0	0	0	1	0	3	2	2	1	2	1	5	6	2	1	2	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:40085595G>A	uc003cka.2	+	3	300	c.165G>A	c.(163-165)AAG>AAA	p.K55K	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.K55K|MYRIP_uc010hhw.2_Missense_Mutation_p.S12N|MYRIP_uc010hhx.1_Silent_p.K55K	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	55	RabBD.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		TCCTCTCGAAGCACCAGCAGT	0.542													4	32					0	0	0	0	A	40085595	A	A	40085595	2	1	90	1	0	0	0	0	0	0	0	1	10153	962	34	4		4	MYRIP	3	40085595	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08		40085595	157936835	11	17699											
NKTR	4820	broad.mit.edu	37	chr3	42659092	42659092	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgtttcagctcttctcagAcatatgtccaaaaacatgca	13	13	5	10	0	3	1	2	0	2	1	5	1	4	1	1	0	3	3	1	0	4	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:42659092A>G	uc003clo.2	+	3	236	c.89A>G	c.(88-90)GAC>GGC	p.D30G	NKTR_uc003cll.1_Missense_Mutation_p.D30G|NKTR_uc003clm.1_5'UTR|NKTR_uc003clp.2_5'UTR|NKTR_uc011azp.1_5'UTR|NKTR_uc003clq.1_5'Flank	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	30	PPIase cyclophilin-type.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CTCTTCTCAGACATATGTCCA	0.328													10	42					0	0	0	0	G	42659092	G	G	42659092	3	3	90	1	0	0	0	0	1	0	0	0	10502	275	10	5	95	5	NKTR	3	42659092	Missense_Mutation	SNP	A	TCGA-CQ-5323-01A-01D-1683-08	2573497	42659092	155363338	12	17700											
NBEAL2	23218	broad.mit.edu	37	chr3	47044464	47044464	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagggacactcccatcccccGctggaaactgtccagcgccg	8	5	10	18	3	0	0	0	0	0	0	3	2	3	2	5	2	2	1	5	2	1	0			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:47044464G>A	uc003cqp.2	+	34	5656	c.5477G>A	c.(5476-5478)CGC>CAC	p.R1826H	NBEAL2_uc010hjm.1_Missense_Mutation_p.R1203H|NBEAL2_uc010hjn.1_Missense_Mutation_p.R222H|NBEAL2_uc010hjo.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1826							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CCCATCCCCCGCTGGAAACTG	0.612													16	19					0	0	0	0	A	47044464	A	A	47044464	3	1	90	1	0	0	0	0	1	0	0	0	10242	1087	38	1	5611	1	NBEAL2	3	47044464	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	4385372	47044464	150977966	13	17701											
PDZRN3	23024	broad.mit.edu	37	chr3	73432746	73432746	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatcatgaactcgcgccGccgccgctgctccttggcct	4	9	10	18	5	1	1	1	1	0	0	3	1	2	1	5	1	3	3	5	1	1	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:73432746G>A	uc003dpl.1	-	10	3067	c.2971C>T	c.(2971-2973)CGG>TGG	p.R991W	PDZRN3_uc011bgh.1_Missense_Mutation_p.R648W|PDZRN3_uc010hoe.1_Missense_Mutation_p.R689W|PDZRN3_uc011bgf.1_Missense_Mutation_p.R708W|PDZRN3_uc011bgg.1_Missense_Mutation_p.R711W	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	991	Potential.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		AACTCGCGCCGCCGCCGCTGC	0.582													14	72					0	0	0	0	A	73432746	A	A	73432746	3	1	90	1	0	0	0	0	1	0	0	0	11763	1086	38	1	233	1	PDZRN3	3	73432746	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	26388282	73432746	124589684	14	17702											
OR5K4	403278	broad.mit.edu	37	chr3	98073476	98073476	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttgtcttctcatgtatattgGaccatctgaagaaggagata	12	14	9	6	0	3	3	1	1	3	2	4	5	3	4	1	2	0	1	1	2	5	6			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:98073476G>C	uc011bgv.1	+	1	779	c.779G>C	c.(778-780)GGA>GCA	p.G260A		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	260	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						ATGTATATTGGACCATCTGAA	0.348													4	178					0	0	0	0	C	98073476	C	C	98073476	3	2	90	1	0	0	0	0	1	0	0	0	11223	1174	41	2	781	2	OR5K4	3	98073476	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	24640730	98073476	99948954	15	17703											
SIDT1	54847	broad.mit.edu	37	chr3	113331029	113331029	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccagatatattatatgggtCgtttcaagataggtgagtca	12	13	10	6	1	2	3	2	1	0	2	3	3	2	3	1	2	0	1	1	2	6	6			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:113331029C>T	uc003eak.2	+	19	2605	c.1954C>T	c.(1954-1956)CGT>TGT	p.R652C	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.R652C|SIDT1_uc011big.1_Missense_Mutation_p.R405C|SIDT1_uc011bih.1_RNA|SIDT1_uc011bii.1_Missense_Mutation_p.R105C	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	652	Cytoplasmic (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						TTATATGGGTCGTTTCAAGAT	0.413													5	65					0	0	0	0	T	113331029	T	T	113331029	3	4	90	1	0	0	0	0	1	0	0	0	14367	884	31	1	2028	1	SIDT1	3	113331029	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	15257553	113331029	84691401	16	17704											
KIAA1407	57577	broad.mit.edu	37	chr3	113723577	113723577	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acttctgccttcagtcccagGggaagcaacaggtgaactag	11	8	11	11	0	2	1	1	1	1	0	3	2	3	2	2	3	4	1	2	3	4	3			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:113723577G>C	uc003eax.2	-	11	2032	c.1885C>G	c.(1885-1887)CCT>GCT	p.P629A	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.P607A	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	629										ovary(2)	2						TCAGTCCCAGGGGAAGCAACA	0.423													27	188					0	0	0	0	C	113723577	C	C	113723577	3	2	90	1	0	0	0	0	1	0	0	0	8268	1232	43	4	953	4	KIAA1407	3	113723577	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	392548	113723577	84298853	17	17705											
HEG1	57493	broad.mit.edu	37	chr3	124692701	124692701	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcagcatacggggacatttgGaaatctccacttttgaagat	12	12	9	8	1	2	2	1	1	1	1	3	4	2	4	1	3	2	1	1	3	3	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:124692701G>C	uc003ehs.3	-	16	3938	c.3870C>G	c.(3868-3870)TTC>TTG	p.F1290L	HEG1_uc003ehr.3_Missense_Mutation_p.F144L|HEG1_uc011bke.1_Missense_Mutation_p.F1390L	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	1290	Cytoplasmic (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GGGACATTTGGAAATCTCCAC	0.383													4	98					0	0	0	0	C	124692701	C	C	124692701	3	2	90	1	0	0	0	0	1	0	0	0	7083	1165	41	2	283	2	HEG1	3	124692701	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	10969124	124692701	73329729	18	17706											
RHO	6010	broad.mit.edu	37	chr3	129251571	129251571	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgttctttgccaagagcGccgccatctacaaccctgtc	8	9	8	16	3	2	1	0	0	2	1	3	1	2	1	4	0	5	1	4	0	3	3			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:129251571G>A	uc003emt.2	+	4	987	c.892G>A	c.(892-894)GCC>ACC	p.A298T		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	298	Helical; Name=7; (Potential).				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	TGCCAAGAGCGCCGCCATCTA	0.602													7	111					0	0	0	0	A	129251571	A	A	129251571	3	1	90	1	0	0	0	0	1	0	0	0	13395	1087	38	1	906	1	RHO	3	129251571	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	4558870	129251571	68770859	19	17707											
KCNMB2	10242	broad.mit.edu	37	chr3	178543544	178543544	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcctgcgctcatacatgcaGaggtaataccactgggtggg	9	9	12	11	1	1	1	1	0	0	1	2	1	2	1	2	3	4	3	2	3	3	3			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:178543544G>A	uc003fjd.2	+	3	568	c.225G>A	c.(223-225)CAG>CAA	p.Q75Q	uc003fjb.1_Intron|uc003fjc.1_Intron|KCNMB2_uc003fje.2_Silent_p.Q75Q|KCNMB2_uc003fjf.2_Silent_p.Q75Q|KCNMB2_uc011bqa.1_Intron|KCNMB2_uc011bqb.1_Intron	NM_181361	NP_852006	Q9Y691	KCMB2_HUMAN	calcium-activated potassium channel beta 2	75	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(1)	1	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			CATACATGCAGAGGTAATACC	0.527													47	255					0	0	0	0	A	178543544	A	A	178543544	2	1	90	1	0	0	0	0	0	0	0	1	8114	933	33	2		2	KCNMB2	3	178543544	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	49291973	178543544	19478886	20	17708											
TFRC	7037	broad.mit.edu	37	chr3	195792459	195792459	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccagtcagagggacagtcTccttccatattcctagaatc	10	12	7	12	0	2	2	1	0	1	2	7	3	5	3	4	1	0	0	4	1	3	5			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr3:195792459T>C	uc003fvz.3	-	10	1336	c.1053A>G	c.(1051-1053)GGA>GGG	p.G351G	TFRC_uc003fwa.3_Silent_p.G351G|TFRC_uc010hzy.2_Silent_p.G270G|TFRC_uc011btr.1_Silent_p.G69G	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	351	Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		AGGGACAGTCTCCTTCCATAT	0.438			T	BCL6	NHL								19	180					0	0	0	0	C	195792459	C	C	195792459	2	2	90	1	0	0	0	0	0	0	0	1	15878	1538	54	5		5	TFRC	3	195792459	Silent	SNP	T	TCGA-CQ-5323-01A-01D-1683-08	17248915	195792459	2229971	21	17709											
CSN2	1447	broad.mit.edu	37	chr4	70826811	70826811	+	5'Flank	DEL	A	-	-																															aaggttactttttataaaacAaaaaaaaaagagagataata																										TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr4:70826811delA	uc003hes.3	-						CSN2_uc003het.3_5'Flank	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor						calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						TTTATAAAACAAAAAAAAAAG	0.264													---	---	---								-	70826811	-	-	70826811	6	5	90	0	1	1	0	1	0	0	0	0	3965	145	5	0		0	CSN2	4	70826811	5'Flank	DEL	A	TCGA-CQ-5323-01A-01D-1683-08		70826811	120327465	22	17710											
FSTL5	56884	broad.mit.edu	37	chr4	162307361	162307361	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagagacatatggagtgccCgtcacatcactattgaaccc	12	8	10	11	1	2	2	2	1	0	1	2	5	2	4	2	2	2	0	2	2	3	3	rs35820116	byFrequency	TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr4:162307361C>T	uc003iqh.2	-	16	2518	c.2082G>A	c.(2080-2082)ACG>ACA	p.T694T	FSTL5_uc003iqi.2_Silent_p.T693T|FSTL5_uc010iqv.2_Silent_p.T684T|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	694						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATGGAGTGCCCGTCACATCAC	0.478													4	49					0	0	0	0	T	162307361	T	T	162307361	2	4	90	1	0	0	0	0	0	0	0	1	6114	639	23	1		1	FSTL5	4	162307361	Silent	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	91480550	162307361	28846915	23	17711											
EGFLAM	133584	broad.mit.edu	37	chr5	38370498	38370498	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataccaactaccagtttgccGtgagggcaatgaattcccat	12	10	8	11	1	0	2	0	2	0	0	1	2	1	2	4	1	4	2	4	1	5	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr5:38370498G>A	uc003jlc.1	+	6	970	c.646G>A	c.(646-648)GTG>ATG	p.V216M	EGFLAM_uc003jlb.1_Missense_Mutation_p.V216M	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	216	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					CCAGTTTGCCGTGAGGGCAAT	0.567													6	31					0	0	0	0	A	38370498	A	A	38370498	3	1	90	1	0	0	0	0	1	0	0	0	4988	1145	40	1	668	1	EGFLAM	5	38370498	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08		38370498	142544762	24	17712											
ITGA1	3672	broad.mit.edu	37	chr5	52235492	52235492	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaagaaaatgactacatcaActgaccatctcaaacgaggc	18	6	7	10	1	2	3	2	2	1	1	3	5	2	3	1	1	3	0	1	1	6	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr5:52235492A>G	uc003jou.2	+	25	3203	c.3151A>G	c.(3151-3153)ACT>GCT	p.T1051A	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Missense_Mutation_p.T582A	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	1051	Extracellular (Potential).				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GACTACATCAACTGACCATCT	0.323													31	37					0	0	0	0	G	52235492	G	G	52235492	3	3	90	1	0	0	0	0	1	0	0	0	7911	43	2	5	3249	5	ITGA1	5	52235492	Missense_Mutation	SNP	A	TCGA-CQ-5323-01A-01D-1683-08	13864994	52235492	128679768	25	17713											
PCDHB15	56121	broad.mit.edu	37	chr5	140626678	140626678	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctccattaacacggacaacgGccacctgttcgctctccagt	9	9	7	16	3	1	0	0	0	1	0	4	1	2	1	4	2	2	2	4	2	2	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr5:140626678G>T	uc003lje.2	+	1	1532	c.1532G>T	c.(1531-1533)GGC>GTC	p.G511V		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	511	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGGACAACGGCCACCTGTTC	0.682													29	89					1.75199e-13	1.99364e-13	1	0	T	140626678	T	T	140626678	3	4	90	1	0	0	0	0	1	0	0	0	11594	1203	42	4	1534	4	PCDHB15	5	140626678	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	88391186	140626678	40288582	26	17714											
PCDHGA3	56112	broad.mit.edu	37	chr5	140723799	140723799	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagcgcggagtccgcatcGtctccagaggtaggacgcag	8	5	16	12	6	1	1	0	0	1	1	4	4	2	4	2	4	1	3	2	4	1	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr5:140723799G>A	uc003ljm.1	+	1	199	c.199G>A	c.(199-201)GTC>ATC	p.V67I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.V67I	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	67	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCCGCATCGTCTCCAGAGG	0.617											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	163					0	0	0	0	A	140723799	A	A	140723799	3	1	90	1	0	0	0	0	1	0	0	0	11609	1145	40	1	201	1	PCDHGA3	5	140723799	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	97121	140723799	40191461	27	17715											
UNC5A	90249	broad.mit.edu	37	chr5	176295646	176295646	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccctgccgtccaccggAgggcatccctccagccgagg	5	5	13	18	3	0	0	0	0	0	0	3	2	3	1	7	3	3	2	7	3	0	0			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr5:176295646A>G	uc003mey.2	+	4	713	c.521A>G	c.(520-522)GAG>GGG	p.E174G	UNC5A_uc003mex.1_Missense_Mutation_p.E174G|UNC5A_uc010jkg.1_Missense_Mutation_p.E134G	NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	174	Ig-like C2-type.|Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGTCCACCGGAGGGCATCCCT	0.662													3	11					0	0	0	0	G	176295646	G	G	176295646	3	3	90	1	0	0	0	0	1	0	0	0	17059	304	11	5	535	5	UNC5A	5	176295646	Missense_Mutation	SNP	A	TCGA-CQ-5323-01A-01D-1683-08	35571847	176295646	4619614	28	17716											
MBOAT1	154141	broad.mit.edu	37	chr6	20126818	20126818	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctccagcaacttcatgtgtAtatgcttcccctcaatgaag	10	12	6	13	0	2	1	2	1	0	0	4	1	4	1	4	0	3	3	4	0	5	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr6:20126818A>G	uc003ncx.1	-	7	849	c.644T>C	c.(643-645)ATA>ACA	p.I215T	MBOAT1_uc011dji.1_Missense_Mutation_p.I66T	NM_001080480	NP_001073949	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain	215					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			CTTCATGTGTATATGCTTCCC	0.408											OREG0017224	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	135					0	0	0	0	G	20126818	G	G	20126818	3	3	90	1	0	0	0	0	1	0	0	0	9409	449	16	5	871	5	MBOAT1	6	20126818	Missense_Mutation	SNP	A	TCGA-CQ-5323-01A-01D-1683-08		20126818	150988249	29	17717											
C6orf27	80737	broad.mit.edu	37	chr6	31734251	31734251	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtctcacctccagaaggaCagggactacagtgctaggct	10	7	12	12	1	1	1	1	0	1	1	3	3	2	3	2	3	2	2	2	3	3	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr6:31734251C>T	uc011dog.1	-	14	2411	c.2173G>A	c.(2173-2175)GTC>ATC	p.V725I	C6orf27_uc003nxd.2_Missense_Mutation_p.V400I	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	725						extracellular region				ovary(3)	3						TCCAGAAGGACAGGGACTACA	0.652													10	4					0	0	0	0	T	31734251	T	T	31734251	3	4	90	1	0	0	0	0	1	0	0	0	2372	478	17	4	517	4	C6orf27	6	31734251	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	11607433	31734251	139380816	30	17718											
GPR110	266977	broad.mit.edu	37	chr6	46977694	46977694	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcatttccatttttggaaaCgggtagaatgttccccagag	11	12	10	8	1	0	2	0	0	0	2	2	3	2	3	3	2	2	3	3	2	3	5			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr6:46977694C>T	uc003oyt.2	-	11	1676	c.1477G>A	c.(1477-1479)GTT>ATT	p.V493I	GPR110_uc011dwl.1_Missense_Mutation_p.V181I	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	493	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TTTTTGGAAACGGGTAGAATG	0.408													7	67					0	0	0	0	T	46977694	T	T	46977694	3	4	90	1	0	0	0	0	1	0	0	0	6665	536	19	1	1275	1	GPR110	6	46977694	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	15243443	46977694	124137373	31	17719											
FIG4	9896	broad.mit.edu	37	chr6	110106193	110106193	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatacttactggtggacacCagaggtgataaagcatttac	13	12	9	7	0	0	2	0	1	0	1	0	3	0	3	1	3	4	1	1	3	6	6			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr6:110106193C>T	uc003ptt.2	+	17	2125	c.1910C>T	c.(1909-1911)CCA>CTA	p.P637L	FIG4_uc011eau.1_Missense_Mutation_p.P360L	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	637					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		TGGTGGACACCAGAGGTGATA	0.269													10	90					0	0	0	0	T	110106193	T	T	110106193	3	4	90	1	0	0	0	0	1	0	0	0	5920	594	21	4	1976	4	FIG4	6	110106193	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	63128499	110106193	61008874	32	17720											
ZNF479	90827	broad.mit.edu	37	chr7	57187579	57187579	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagggtttctctccagtgtGaattatcttatgtttagcaa	9	17	9	6	0	2	1	0	1	2	0	4	1	3	1	1	1	1	4	1	1	6	6			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr7:57187579G>A	uc010kzo.2	-	5	1814	c.1543C>T	c.(1543-1545)CAC>TAC	p.H515Y		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	515	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TCTCCAGTGTGAATTATCTTA	0.348													5	20					0	0	0	0	A	57187579	A	A	57187579	3	1	90	1	0	0	0	0	1	0	0	0	18000	1290	45	2	35	2	ZNF479	7	57187579	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08		57187579	101951084	33	17721											
ZNF394	84124	broad.mit.edu	37	chr7	99097569	99097569	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agccgcgggatagttgggctCccaacttccgggtgagtctt	6	10	14	11	3	1	1	0	1	1	0	3	2	3	2	3	3	2	2	3	3	2	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr7:99097569C>T	uc003uqs.2	-	1	309	c.148G>A	c.(148-150)GAG>AAG	p.E50K	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Missense_Mutation_p.E50K	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	50					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TAGTTGGGCTCCCAACTTCCG	0.642													8	57					0	0	0	0	T	99097569	T	T	99097569	3	4	90	1	0	0	0	0	1	0	0	0	17947	864	30	2	1549	2	ZNF394	7	99097569	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	41909990	99097569	60041094	34	17722											
TAS2R16	50833	broad.mit.edu	37	chr7	122634844	122634844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctttagaatccttttcaacGtagggctgctcagcatcagt	9	13	8	11	1	3	1	3	0	0	1	4	1	4	1	2	1	3	4	2	1	4	5			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr7:122634844G>A	uc003vkl.1	-	1	911	c.845C>T	c.(844-846)ACG>ATG	p.T282M		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	282	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						CCTTTTCAACGTAGGGCTGCT	0.423													27	109					0	0	0	0	A	122634844	A	A	122634844	3	1	90	1	0	0	0	0	1	0	0	0	15635	1145	40	1	34	1	TAS2R16	7	122634844	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	23537275	122634844	36503819	35	17723											
CSMD1	64478	broad.mit.edu	37	chr8	2976061	2976061	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtaatccgagttgatcatgTacccattctgaaatgggggt	10	13	11	7	1	2	2	1	2	1	0	3	3	3	2	2	2	1	3	2	2	3	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr8:2976061T>C	uc011kwk.1	-	42	6683	c.6293A>G	c.(6292-6294)TAC>TGC	p.Y2098C	CSMD1_uc011kwj.1_Missense_Mutation_p.Y1490C|CSMD1_uc010lrg.2_Missense_Mutation_p.Y166C	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2098	Extracellular (Potential).|Sushi 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTTGATCATGTACCCATTCTG	0.418													22	56					0	0	0	0	C	2976061	C	C	2976061	3	2	90	1	0	0	0	0	1	0	0	0	3961	1638	57	5	4520	5	CSMD1	8	2976061	Missense_Mutation	SNP	T	TCGA-CQ-5323-01A-01D-1683-08		2976061	143387961	36	17724											
PKHD1L1	93035	broad.mit.edu	37	chr8	110447468	110447468	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagtgctggacatgccccCgttgctgtgtccatggctga	6	10	14	11	1	0	1	0	1	0	0	1	3	1	3	3	3	3	4	3	3	1	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr8:110447468C>T	uc003yne.2	+	29	3494	c.3390C>T	c.(3388-3390)CCC>CCT	p.P1130P		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1130	Extracellular (Potential).|IPT/TIG 4.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GACATGCCCCCGTTGCTGTGT	0.408										HNSCC(38;0.096)			55	83					0	0	0	0	T	110447468	T	T	110447468	2	4	90	1	0	0	0	0	0	0	0	1	12027	639	23	1		1	PKHD1L1	8	110447468	Silent	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	107471407	110447468	35916554	37	17725											
LINGO2	158038	broad.mit.edu	37	chr9	27949442	27949442	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttcttttcacggattttggGttttttgcaggtaaagtaaa	9	18	9	5	1	2	0	1	0	1	0	2	1	2	1	0	3	1	4	0	3	4	10			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:27949442G>T	uc003zqu.1	-	2	1422	c.1228C>A	c.(1228-1230)CCC>ACC	p.P410T	LINGO2_uc010mjf.1_Missense_Mutation_p.P410T|LINGO2_uc003zqv.1_Missense_Mutation_p.P410T	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	410	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CGGATTTTGGGTTTTTTGCAG	0.488													12	73					4.36969e-10	4.86067e-10	1	0	T	27949442	T	T	27949442	3	4	90	1	0	0	0	0	1	0	0	0	8857	1261	44	4	596	4	LINGO2	9	27949442	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08		27949442	113263989	38	17726											
PAX5	5079	broad.mit.edu	37	chr9	37015016	37015016	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gttgatggaactgacgctagGcacggtgtcattgtcacaca	10	10	12	9	2	2	2	2	2	0	0	2	3	2	3	0	3	1	3	0	3	2	3			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:37015016G>A	uc003zzo.1	-	3	836	c.388C>T	c.(388-390)CCT>TCT	p.P130S	PAX5_uc011lpw.1_Missense_Mutation_p.P130S|PAX5_uc011lpx.1_Intron|PAX5_uc011lpy.1_Missense_Mutation_p.P22S|PAX5_uc010mls.1_Missense_Mutation_p.P130S|PAX5_uc011lpz.1_Missense_Mutation_p.P130S|PAX5_uc011lqa.1_Missense_Mutation_p.P22S|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.P130S|PAX5_uc010mlp.1_Missense_Mutation_p.P130S|PAX5_uc011lqc.1_Missense_Mutation_p.P130S|PAX5_uc010mlr.1_Missense_Mutation_p.P130S|PAX5_uc011lqd.1_Intron|PAX5_uc011lqe.1_RNA|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_RNA	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	130	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(32)|p.N126_P130>RA(1)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CTGACGCTAGGCACGGTGTCA	0.572			T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								10	161					0	0	0	0	A	37015016	A	A	37015016	3	1	90	1	0	0	0	0	1	0	0	0	11536	1203	42	4	819	4	PAX5	9	37015016	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	9065574	37015016	104198415	39	17727											
AGTPBP1	23287	broad.mit.edu	37	chr9	88193977	88193977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacagctgctcatgcaaaatGctggggcgatatggctcagt	10	10	12	9	1	2	0	2	0	0	0	2	1	2	0	0	3	5	5	0	3	4	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:88193977G>A	uc011ltd.1	-	23	3233	c.3200C>T	c.(3199-3201)GCA>GTA	p.A1067V	AGTPBP1_uc004aod.3_Missense_Mutation_p.A693V|AGTPBP1_uc011ltc.1_Intron|AGTPBP1_uc010mqc.2_Missense_Mutation_p.A1027V|AGTPBP1_uc011lte.1_Missense_Mutation_p.A1079V	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1067					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						CATGCAAAATGCTGGGGCGAT	0.338													44	35					0	0	0	0	A	88193977	A	A	88193977	3	1	90	1	0	0	0	0	1	0	0	0	400	1319	46	4	492	4	AGTPBP1	9	88193977	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	51178961	88193977	53019454	40	17728											
FAM75C1	441452	broad.mit.edu	37	chr9	90538055	90538055	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaacatgtcactttgccatgCgcgccatgcctcgaaggtaa	10	9	10	12	3	1	0	1	0	0	0	2	2	1	0	3	1	4	1	3	1	3	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:90538055C>T	uc010mqi.2	+	4	3262	c.3233C>T	c.(3232-3234)GCG>GTG	p.A1078V	FAM75C1_uc004apq.3_Missense_Mutation_p.A1061V	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						CTTTGCCATGCGCGCCATGCC	0.527													5	116					0	0	0	0	T	90538055	T	T	90538055	3	4	90	1	0	0	0	0	1	0	0	0	5655	768	27	1	3247	1	FAM75C1	9	90538055	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	2344078	90538055	50675376	41	17729											
ROR2	4920	broad.mit.edu	37	chr9	94486331	94486331	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgacggggacgtagagctgCggcgggggcaccatgggtct	6	7	19	9	4	1	2	0	1	1	1	1	3	1	3	1	6	2	3	1	6	1	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:94486331C>T	uc004arj.1	-	9	2644	c.2445G>A	c.(2443-2445)CCG>CCA	p.P815P	ROR2_uc004ari.1_Intron	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	815	Cytoplasmic (Potential).|Pro-rich.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						CGTAGAGCTGCGGCGGGGGCA	0.677													8	78					0	0	0	0	T	94486331	T	T	94486331	2	4	90	1	0	0	0	0	0	0	0	1	13592	755	27	1		1	ROR2	9	94486331	Silent	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	3948276	94486331	46727100	42	17730											
ZNF484	83744	broad.mit.edu	37	chr9	95609543	95609543	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggtgcttaatgagatttGacctgtcagtaaaggcctta	10	15	10	6	0	1	2	1	2	0	1	1	3	1	2	2	2	1	2	2	2	4	5			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:95609543G>T	uc004asu.1	-	5	1675	c.1526C>A	c.(1525-1527)TCA>TAA	p.S509*	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Nonsense_Mutation_p.S511*|ZNF484_uc010mrb.1_Nonsense_Mutation_p.S473*|ZNF484_uc004asv.1_Nonsense_Mutation_p.S473*	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	509	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AATGAGATTTGACCTGTCAGT	0.393													42	131					2.19962e-31	2.56191e-31	1	0	T	95609543	T	T	95609543	4	4	90	1	0	0	0	0	0	1	0	0	18004	1294	45	2	1036	2	ZNF484	9	95609543	Nonsense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	1123212	95609543	45603888	43	17731											
GABBR2	9568	broad.mit.edu	37	chr9	101470780	101470780	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctcgatggccagttccacGgcggggagcacaccgcgccc	6	5	14	16	5	0	0	0	0	0	0	2	2	1	1	4	4	2	3	4	4	0	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:101470780G>A	uc004ays.2	-	1	396	c.240C>T	c.(238-240)GCC>GCT	p.A80A		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	80	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	CCAGTTCCACGGCGGGGAGCA	0.627													11	8					0	0	0	0	A	101470780	A	A	101470780	2	1	90	1	0	0	0	0	0	0	0	1	6190	1103	39	1		1	GABBR2	9	101470780	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	5861237	101470780	39742651	44	17732											
DBC1	1620	broad.mit.edu	37	chr9	121930087	121930087	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgagggacatgcgcttgcGccaccgagggtcaaagaagg	11	5	16	9	3	1	2	1	1	0	1	1	4	1	3	2	3	2	1	2	3	2	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:121930087G>A	uc004bkc.2	-	8	2017	c.1561C>T	c.(1561-1563)CGC>TGC	p.R521C		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	521					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						ATGCGCTTGCGCCACCGAGGG	0.562													20	28					0	0	0	0	A	121930087	A	A	121930087	3	1	90	1	0	0	0	0	1	0	0	0	4264	1087	38	1	728	1	DBC1	9	121930087	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	20459307	121930087	19283344	45	17733											
FNBP1	23048	broad.mit.edu	37	chr9	132740855	132740855	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgcgtaatcattcatttcGttcaggttggaaatgaaagc	11	13	9	8	2	3	1	3	1	0	0	4	2	3	2	1	2	2	3	1	2	3	5			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:132740855G>A	uc004byw.1	-	4	453	c.234C>T	c.(232-234)AAC>AAT	p.N78N	FNBP1_uc011mbv.1_Silent_p.N78N|FNBP1_uc011mbw.1_Silent_p.N78N|FNBP1_uc004bza.2_Silent_p.N78N|FNBP1_uc004byz.1_Silent_p.N78N|FNBP1_uc004byx.1_Translation_Start_Site|FNBP1_uc004byy.1_Translation_Start_Site	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	78	Interaction with microtubules (By similarity).|Required for self-association and induction of membrane tubulation.|Self-association, lipid-binding and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		CATTCATTTCGTTCAGGTTGG	0.433			T	MLL	AML								8	49					0	0	0	0	A	132740855	A	A	132740855	2	1	90	1	0	0	0	0	0	0	0	1	5997	1136	40	1		1	FNBP1	9	132740855	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	10810768	132740855	8472576	46	17734											
LAMC3	10319	broad.mit.edu	37	chr9	133907471	133907471	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactcctcatctctctagacCggctcaacacgtttggggac	9	10	8	14	2	4	1	2	0	2	1	6	2	5	2	2	3	2	2	2	3	3	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr9:133907471C>T	uc004caa.1	+	3	816	c.718C>T	c.(718-720)CGG>TGG	p.R240W		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	240	Laminin N-terminal.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CTCTCTAGACCGGCTCAACAC	0.567													10	149					0	0	0	0	T	133907471	T	T	133907471	3	4	90	1	0	0	0	0	1	0	0	0	8656	643	23	1	728	1	LAMC3	9	133907471	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	1166616	133907471	7305960	47	17735											
PTCHD3	374308	broad.mit.edu	37	chr10	27687277	27687277	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaacatctgttgtctgaatGaagccccgggaagaaatgat	14	9	11	7	1	2	4	0	3	2	1	2	6	2	5	2	1	2	1	2	1	5	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:27687277G>A	uc001itu.2	-	4	2368	c.2250C>T	c.(2248-2250)TTC>TTT	p.F750F		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	750					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TTGTCTGAATGAAGCCCCGGG	0.318													4	24					0	0	0	0	A	27687277	A	A	27687277	2	1	90	1	0	0	0	0	0	0	0	1	12796	1281	45	2		2	PTCHD3	10	27687277	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08		27687277	107847470	48	17736											
LYZL1	84569	broad.mit.edu	37	chr10	29581596	29581596	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagaacaaccactgccatgtCgcctgctcaggtgaggctct	9	8	11	13	1	2	2	1	1	1	1	3	3	2	2	3	2	4	2	3	2	2	0			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:29581596C>T	uc001iul.2	+	3	483	c.426C>T	c.(424-426)GTC>GTT	p.V142V		NM_032517	NP_115906	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	96					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Breast(68;0.203)				ACTGCCATGTCGCCTGCTCAG	0.537													15	54					0	0	0	0	T	29581596	T	T	29581596	2	4	90	1	0	0	0	0	0	0	0	1	9182	871	31	1		1	LYZL1	10	29581596	Silent	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	1894319	29581596	105953151	49	17737											
PARD3	56288	broad.mit.edu	37	chr10	34671799	34671808	+	Frame_Shift_Del	DEL	ATGGAACCAA	-	-																															ttatttgctgcaggaaccacAtggaaccaaatgatgggtgt																										TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:34671799_34671808delATGGAACCAA	uc010qej.1	-	9	1059_1068	c.1059_1068delTTGGTTCCAT	c.(1057-1068)ATTTGGTTCCATfs	p.I353fs	PARD3_uc010qek.1_Frame_Shift_Del_p.I353fs|PARD3_uc010qel.1_Frame_Shift_Del_p.I353fs|PARD3_uc010qem.1_Frame_Shift_Del_p.I353fs|PARD3_uc010qen.1_Frame_Shift_Del_p.I353fs|PARD3_uc010qeo.1_Frame_Shift_Del_p.I353fs|PARD3_uc010qep.1_Frame_Shift_Del_p.I309fs|PARD3_uc010qeq.1_Frame_Shift_Del_p.I309fs|PARD3_uc001ixo.1_Frame_Shift_Del_p.I83fs|PARD3_uc001ixp.1_Frame_Shift_Del_p.I218fs|PARD3_uc001ixq.1_Frame_Shift_Del_p.I353fs|PARD3_uc001ixr.1_Frame_Shift_Del_p.I353fs|PARD3_uc001ixt.1_Frame_Shift_Del_p.I174fs|PARD3_uc001ixu.1_Frame_Shift_Del_p.I309fs|PARD3_uc001ixs.1_Frame_Shift_Del_p.I6fs	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	353_356	PDZ 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CAGGAACCACATGGAACCAAATGATGGGTG	0.4													---	---	---								-	34671808	-	-	34671799	7	5	90	1	0	1	0	1	0	0	0	0	11497	214	8	0	3105	0	PARD3	10	34671799	Frame_Shift_Del	DEL	ATGGAACCAA	TCGA-CQ-5323-01A-01D-1683-08	5090203	34671799	100862948	50	17738											
TET1	80312	broad.mit.edu	37	chr10	70405630	70405630	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aataatgaagtggagtattgCaaccagttactggacagcag	15	9	11	6	0	0	1	0	1	0	0	0	3	0	3	1	2	4	4	1	2	6	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:70405630C>A	uc001jok.3	+	4	3649	c.3144C>A	c.(3142-3144)TGC>TGA	p.C1048*		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1048					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TGGAGTATTGCAACCAGTTAC	0.388													18	80					2.94398e-08	3.23838e-08	1	0	A	70405630	A	A	70405630	4	1	90	1	0	0	0	0	0	1	0	0	15835	718	25	4	3154	4	TET1	10	70405630	Nonsense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	35733831	70405630	65129117	51	17739											
FAM190B	54462	broad.mit.edu	37	chr10	86131078	86131078	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatactcaaaattcacatgaTaaaataattgatcctgaaaa	21	11	3	6	0	2	3	2	3	0	0	3	3	3	3	1	0	1	0	1	0	9	5			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:86131078T>C	uc001kdh.1	+	2	464	c.270T>C	c.(268-270)GAT>GAC	p.D90D	FAM190B_uc001kdg.1_Silent_p.D90D|FAM190B_uc010qmd.1_Silent_p.D90D	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	90										ovary(3)|skin(1)	4						ATTCACATGATAAAATAATTG	0.328													3	46					0	0	0	0	C	86131078	C	C	86131078	2	2	90	1	0	0	0	0	0	0	0	1	5550	1403	49	5		5	FAM190B	10	86131078	Silent	SNP	T	TCGA-CQ-5323-01A-01D-1683-08	15725448	86131078	49403669	52	17740											
TAF5	6877	broad.mit.edu	37	chr10	105146990	105146990	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccggccatcttgctgatGtgaattgtaccagattccat	8	14	9	10	1	1	3	0	2	1	1	2	3	2	3	4	1	3	2	4	1	2	5			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:105146990G>T	uc001kwv.2	+	9	1911	c.1888G>T	c.(1888-1890)GTG>TTG	p.V630L	TAF5_uc010qqq.1_Missense_Mutation_p.V575L	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	630	WD 4.				histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		TCTTGCTGATGTGAATTGTAC	0.423													21	39					7.45023e-12	8.3815e-12	1	0	T	105146990	T	T	105146990	3	4	90	1	0	0	0	0	1	0	0	0	15594	1377	48	4	1922	4	TAF5	10	105146990	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	19015912	105146990	30387757	53	17741											
PLEKHA1	59338	broad.mit.edu	37	chr10	124186509	124186509	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaagcagtctctggcgccAttgtagcacagcggggtccc	8	9	12	12	2	1	0	0	0	1	0	3	0	2	0	2	3	3	3	2	3	3	3			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:124186509A>G	uc001lge.1	+	11	985	c.862A>G	c.(862-864)ATT>GTT	p.I288V	PLEKHA1_uc001lgf.1_Missense_Mutation_p.I288V|PLEKHA1_uc001lgg.1_Missense_Mutation_p.I288V|PLEKHA1_uc001lgh.2_Missense_Mutation_p.I288V	NM_001001974	NP_001001974	Q9HB21	PKHA1_HUMAN	pleckstrin homology domain containing, family A	288	PH 2.				B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			kidney(1)	1		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTCTGGCGCCATTGTAGCACA	0.473													21	43					0	0	0	0	G	124186509	G	G	124186509	3	3	90	1	0	0	0	0	1	0	0	0	12110	217	8	5	900	5	PLEKHA1	10	124186509	Missense_Mutation	SNP	A	TCGA-CQ-5323-01A-01D-1683-08	19039519	124186509	11348238	54	17742											
DPYSL4	10570	broad.mit.edu	37	chr10	134008356	134008356	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccttcacagtggaccaCgtcttccccgacacgggtgt	6	9	11	15	3	2	0	1	0	1	0	3	2	3	1	4	2	1	1	4	2	0	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr10:134008356C>T	uc009ybb.2	+	4	475	c.321C>T	c.(319-321)CAC>CAT	p.H107H		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	107					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CAGTGGACCACGTCTTCCCCG	0.642													26	77					0	0	0	0	T	134008356	T	T	134008356	2	4	90	1	0	0	0	0	0	0	0	1	4771	535	19	1		1	DPYSL4	10	134008356	Silent	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	9821847	134008356	1526391	55	17743											
TOLLIP	54472	broad.mit.edu	37	chr11	1309866	1309866	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctcaccgcgtaggacatGacgaggttgatcatgccctc	9	8	11	13	3	2	2	2	2	0	0	3	4	2	3	2	2	2	3	2	2	1	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr11:1309866G>A	uc001lte.2	-	4	618	c.507C>T	c.(505-507)GTC>GTT	p.V169V	TOLLIP_uc001ltd.2_Silent_p.V100V|TOLLIP_uc009ycu.2_Silent_p.V108V|TOLLIP_uc001ltf.2_Silent_p.V119V	NM_019009	NP_061882	Q9H0E2	TOLIP_HUMAN	toll interacting protein	169					cell-cell signaling|inflammatory response|innate immune response|intracellular signal transduction|leukocyte activation|phosphorylation	cytosol|interleukin-1 receptor complex|interleukin-18 receptor complex	kinase binding|signal transducer activity|Toll-like receptor binding				0		all_cancers(49;7.62e-05)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.00152)|Lung(200;0.09)|LUSC - Lung squamous cell carcinoma(625;0.107)		CGTAGGACATGACGAGGTTGA	0.647													13	25					0	0	0	0	A	1309866	A	A	1309866	2	1	90	1	0	0	0	0	0	0	0	1	16416	1277	45	2		2	TOLLIP	11	1309866	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08		1309866	133696650	56	17744											
NELL1	4745	broad.mit.edu	37	chr11	21594899	21594899	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagctatggtgtttcacggCttagtggctcagtgtggacg	7	12	14	8	2	2	0	2	0	0	0	2	1	2	1	0	4	1	4	0	4	2	3			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr11:21594899C>G	uc001mqe.2	+	19	2479	c.2326C>G	c.(2326-2328)CTT>GTT	p.L776V	NELL1_uc001mqf.2_Missense_Mutation_p.L729V|NELL1_uc009yid.2_Missense_Mutation_p.L804V|NELL1_uc010rdo.1_Missense_Mutation_p.L719V|NELL1_uc010rdp.1_Missense_Mutation_p.L489V|NELL1_uc001mqh.2_Missense_Mutation_p.L321V	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	776	VWFC 5.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TGTTTCACGGCTTAGTGGCTC	0.493													10	107					0	0	0	0	G	21594899	G	G	21594899	3	3	90	1	0	0	0	0	1	0	0	0	10387	797	28	4	2400	4	NELL1	11	21594899	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	20285033	21594899	113411617	57	17745											
CFL1	1072	broad.mit.edu	37	chr11	65623573	65623573	+	Silent	SNP	G	A	A																															atctccttgccctcctccagGatgatgttcttcttgtcctc																								rs144718277		TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr11:65623573G>A	uc001ofs.2	-	2	378	c.144C>T	c.(142-144)ATC>ATT	p.I48I	CFL1_uc001oft.2_Silent_p.I48I|CFL1_uc001ofu.2_3'UTR	NM_005507	NP_005498	P23528	COF1_HUMAN	cofilin 1 (non-muscle)	48	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding				0				READ - Rectum adenocarcinoma(159;0.169)		CCTCCTCCAGGATGATGTTCT	0.562													5	54					0	0	0	0	A	65623573	A	A	65623573	2	1	90	1	0	0	0	0	0	0	0	1	3305	1164	41	2		2	CFL1	11	65623573	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	44028674	65623573	69382943	58	17746	36	2									
CFL1	1072	broad.mit.edu	37	chr11	65623576	65623576	+	Silent	SNP	G	A	A																															tccttgccctcctccaggatGatgttcttcttgtcctcact																										TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr11:65623576G>A	uc001ofs.2	-	2	375	c.141C>T	c.(139-141)ATC>ATT	p.I47I	CFL1_uc001oft.2_Silent_p.I47I|CFL1_uc001ofu.2_3'UTR	NM_005507	NP_005498	P23528	COF1_HUMAN	cofilin 1 (non-muscle)	47	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding				0				READ - Rectum adenocarcinoma(159;0.169)		CCTCCAGGATGATGTTCTTCT	0.557													4	58					0	0	0	0	A	65623576	A	A	65623576	2	1	90	1	0	0	0	0	0	0	0	1	3305	1280	45	2		2	CFL1	11	65623576	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	3	65623576	69382940	59	17747	36	2									
CD163	9332	broad.mit.edu	37	chr12	7636068	7636069	+	Frame_Shift_Ins	INS	-	A	A																															ttccctttgcacttcacttcINSattgagccatatcggtccag																										TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr12:7636068_7636069insA	uc001qsz.3	-	12	3110_3111	c.2982_2983insT	c.(2980-2985)AATGAAfs	p.N994fs	CD163_uc001qta.3_Frame_Shift_Ins_p.N994fs|CD163_uc009zfw.2_Frame_Shift_Ins_p.N1027fs	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	994_995	SRCR 9.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CACTTCACTTCATTGAGCCATA	0.515													---	---	---								A	7636069	A	A	7636068	7	5	90	1	0	1	1	0	0	0	0	0	2982	835	29	0	507	0	CD163	12	7636068	Frame_Shift_Ins	INS	-	TCGA-CQ-5323-01A-01D-1683-08		7636068	126215827	60	17748											
PZP	5858	broad.mit.edu	37	chr12	9349218	9349218	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctaagcttcatttcaaagcCcgtatttgtaatctggagca	11	14	7	9	1	4	0	2	0	2	0	4	1	4	1	1	1	3	4	1	1	4	6			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr12:9349218C>G	uc001qvl.2	-	9	960	c.931G>C	c.(931-933)GGC>CGC	p.G311R	PZP_uc009zgl.2_Missense_Mutation_p.G180R	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						ATTTCAAAGCCCGTATTTGTA	0.393													20	58					0	0	0	0	G	9349218	G	G	9349218	3	3	90	1	0	0	0	0	1	0	0	0	12934	623	22	4	3629	4	PZP	12	9349218	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	1713150	9349218	124502677	61	17749											
MLL2	8085	broad.mit.edu	37	chr12	49447022	49447022	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agagtgagcaggcagttcctCcatgggtggttttaggcaga	9	10	15	7	0	0	3	0	1	0	2	2	3	2	3	2	4	1	5	2	4	1	3			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr12:49447022C>A	uc001rta.3	-	7	922	c.922G>T	c.(922-924)GAG>TAG	p.E308*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	308	PHD-type 2.|RING-type 2; degenerate.|Cys-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCAGTTCCTCCATGGGTGGT	0.478			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			25	92					1.32003e-05	1.42047e-05	1	0	A	49447022	A	A	49447022	4	1	90	1	0	0	0	0	0	1	0	0	9674	864	30	2	15883	2	MLL2	12	49447022	Nonsense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	40097804	49447022	84404873	62	17750											
KRT5	3852	broad.mit.edu	37	chr12	52911893	52911894	+	Frame_Shift_Ins	INS	-	A	A																															cacccacacgcaccttcttcINSagcatcacaaactcattctc																										TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr12:52911893_52911894insA	uc001san.2	-	3	987_988	c.824_825insT	c.(823-825)CTGfs	p.L275fs	KRT5_uc009zmh.2_Frame_Shift_Ins_p.L275fs	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	275	Rod.|Coil 1B.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCACCTTCTTCAGCATCACAAA	0.52													---	---	---								A	52911894	A	A	52911893	7	5	90	1	0	1	1	0	0	0	0	0	8518	813	29	0	975	0	KRT5	12	52911893	Frame_Shift_Ins	INS	-	TCGA-CQ-5323-01A-01D-1683-08	3464871	52911893	80940002	63	17751											
CCNA1	8900	broad.mit.edu	37	chr13	37014297	37014297	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggcgacaaggagtgtgcGtcaggactgagaacctggct	10	7	16	8	2	1	2	1	2	0	1	1	6	1	4	1	4	2	1	1	4	2	0			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr13:37014297G>A	uc001uvr.3	+	6	1425	c.1075G>A	c.(1075-1077)GTC>ATC	p.V359I	CCNA1_uc010teo.1_Missense_Mutation_p.V315I|CCNA1_uc010abq.2_Missense_Mutation_p.V315I|CCNA1_uc010abp.2_Missense_Mutation_p.V315I|CCNA1_uc001uvs.3_Missense_Mutation_p.V358I|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	359					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		AGGAGTGTGCGTCAGGACTGA	0.463													30	24					0	0	0	0	A	37014297	A	A	37014297	3	1	90	1	0	0	0	0	1	0	0	0	2924	1145	40	1	1097	1	CCNA1	13	37014297	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08		37014297	78155581	64	17752											
STRN3	29966	broad.mit.edu	37	chr14	31380280	31380280	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggatctacactgggactcgGcatattccaccactggatgg	9	10	11	11	1	1	0	0	0	1	0	3	3	2	3	2	5	1	1	2	5	2	3			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr14:31380280G>A	uc001wqu.2	-	13	1903	c.1687C>T	c.(1687-1689)CCG>TCG	p.P563S	STRN3_uc001wqv.2_Missense_Mutation_p.P479S|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	563	WD 2.				negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		CTGGGACTCGGCATATTCCAC	0.368													3	70					0	0	0	0	A	31380280	A	A	31380280	3	1	90	1	0	0	0	0	1	0	0	0	15396	1203	42	4	730	4	STRN3	14	31380280	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08		31380280	75969260	65	17753											
BAHD1	22893	broad.mit.edu	37	chr15	40758306	40758306	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctatgacttccgccacgggCgcatccttaagaacccccag	9	8	8	16	3	1	2	0	1	1	1	3	2	3	2	5	1	1	1	5	1	3	3			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr15:40758306C>T	uc001zlu.2	+	7	2391	c.2320C>T	c.(2320-2322)CGC>TGC	p.R774C	BAHD1_uc001zlt.2_Missense_Mutation_p.R773C|BAHD1_uc010bbp.1_Missense_Mutation_p.R770C|BAHD1_uc001zlv.2_Missense_Mutation_p.R771C	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	774	BAH.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CCGCCACGGGCGCATCCTTAA	0.622													20	64					0	0	0	0	T	40758306	T	T	40758306	3	4	90	1	0	0	0	0	1	0	0	0	1299	768	27	1	2342	1	BAHD1	15	40758306	Missense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08		40758306	61773086	66	17754											
ZFAND6	54469	broad.mit.edu	37	chr15	80412738	80412738	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgctttgttccactggcTgtggattttatggaaaccct	7	16	9	9	0	0	0	0	0	0	0	1	2	1	2	2	3	2	3	2	3	3	5			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr15:80412738T>G	uc002bfe.1	+	3	363	c.52T>G	c.(52-54)TGT>GGT	p.C18G	ZFAND6_uc002bff.1_Missense_Mutation_p.C18G|ZFAND6_uc002bfg.1_Missense_Mutation_p.C18G|ZFAND6_uc002bfh.1_Missense_Mutation_p.C18G|ZFAND6_uc002bfi.1_Missense_Mutation_p.C18G	NM_019006	NP_061879	Q6FIF0	ZFAN6_HUMAN	zinc finger, AN1-type domain 6	18	A20-type.						DNA binding|zinc ion binding				0						TTCCACTGGCTGTGGATTTTA	0.393													29	58					0	0	0	0	G	80412738	G	G	80412738	3	3	90	1	0	0	0	0	1	0	0	0	17698	1580	55	5	54	5	ZFAND6	15	80412738	Missense_Mutation	SNP	T	TCGA-CQ-5323-01A-01D-1683-08	39654432	80412738	22118654	67	17755											
HYDIN	54768	broad.mit.edu	37	chr16	70891747	70891747	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgactcagtgatgcccagAtggaaaggtgtgaactggaa	13	8	14	6	0	1	4	1	3	0	1	1	7	1	6	1	3	2	0	1	3	3	0			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr16:70891747A>T	uc002ezr.2	-	72	12281	c.12153T>A	c.(12151-12153)CAT>CAA	p.H4051Q	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4052										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TGATGCCCAGATGGAAAGGTG	0.468													3	9					0	0	0	0	T	70891747	T	T	70891747	3	4	90	1	0	0	0	0	1	0	0	0	7506	330	12	5	3269	5	HYDIN	16	70891747	Missense_Mutation	SNP	A	TCGA-CQ-5323-01A-01D-1683-08		70891747	19463006	68	17756											
SLC13A5	284111	broad.mit.edu	37	chr17	6599181	6599181	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggacaagggccccagcttccGgtactcctcctgcagcacct	7	7	10	17	1	0	0	0	0	0	0	3	1	3	1	6	3	4	4	6	3	2	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr17:6599181G>T	uc002gdj.2	-	7	1007	c.919C>A	c.(919-921)CGG>AGG	p.R307R	SLC13A5_uc010vtf.1_Silent_p.R307R|SLC13A5_uc010clq.2_Silent_p.R264R|SLC13A5_uc002gdk.2_Silent_p.R290R|SLC13A5_uc002gdl.1_Silent_p.R289R	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	307						integral to membrane	citrate transmembrane transporter activity				0						CCCAGCTTCCGGTACTCCTCC	0.567													26	156					6.07407e-21	6.99225e-21	1	0	T	6599181	T	T	6599181	2	4	90	1	0	0	0	0	0	0	0	1	14460	1115	39	3		3	SLC13A5	17	6599181	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08		6599181	74596029	69	17757											
DNAH9	1770	broad.mit.edu	37	chr17	11725866	11725866	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccacgagtggcctcagcaaGcattggagtctgtcagcctc	8	9	11	13	1	3	0	2	0	1	0	5	2	4	1	3	2	3	2	3	2	1	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr17:11725866G>C	uc002gne.2	+	47	9030	c.8962G>C	c.(8962-8964)GCA>CCA	p.A2988P	DNAH9_uc010coo.2_Missense_Mutation_p.A2282P	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2988	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCCTCAGCAAGCATTGGAGTC	0.532													7	175					0	0	0	0	C	11725866	C	C	11725866	3	2	90	1	0	0	0	0	1	0	0	0	4630	971	34	4	9148	4	DNAH9	17	11725866	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	5126685	11725866	69469344	70	17758											
KRT39	390792	broad.mit.edu	37	chr17	39118800	39118800	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctctccccaagctgacactGtaaagaattgatttcctaag	12	12	6	11	0	1	3	0	2	1	1	4	3	3	3	3	0	1	2	3	0	5	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr17:39118800G>A	uc002hvo.1	-	4	760	c.724C>T	c.(724-726)CAG>TAG	p.Q242*	KRT39_uc010wfm.1_5'UTR	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	242	Rod.|Coil 1B.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				AGCTGACACTGTAAAGAATTG	0.418													4	133					0	0	0	0	A	39118800	A	A	39118800	4	1	90	1	0	0	0	0	0	1	0	0	8515	1386	48	4	767	4	KRT39	17	39118800	Nonsense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	27392934	39118800	42076410	71	17759											
KRT36	8689	broad.mit.edu	37	chr17	39644901	39644901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggcccactcacttggtccGgaagtcgtcagcagccagct	8	7	11	15	2	2	0	2	0	0	0	4	1	3	1	3	3	3	2	3	3	1	1	rs148033888	byFrequency	TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr17:39644901G>A	uc002hwt.2	-	2	535	c.535C>T	c.(535-537)CGG>TGG	p.R179W		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	179	Rod.|Coil 1B.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				CACTTGGTCCGGAAGTCGTCA	0.552													23	42					0	0	0	0	A	39644901	A	A	39644901	3	1	90	1	0	0	0	0	1	0	0	0	8512	1115	39	1	892	1	KRT36	17	39644901	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	526101	39644901	41550309	72	17760											
TRIM37	4591	broad.mit.edu	37	chr17	57125153	57125153	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctcataaacaagatccaGatccagatctccatctgaaa	16	9	4	12	0	3	4	1	1	2	3	7	4	6	4	4	0	1	0	4	0	4	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr17:57125153G>A	uc002iwy.3	-	16	2002	c.1558C>T	c.(1558-1560)CTG>TTG	p.L520L	TRIM37_uc002iwz.3_Silent_p.L520L|TRIM37_uc002ixa.3_Silent_p.L398L|TRIM37_uc010woc.1_Silent_p.L486L	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	520						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					ACAAGATCCAGATCCAGATCT	0.418									Mulibrey_Nanism				5	57					0	0	0	0	A	57125153	A	A	57125153	2	1	90	1	0	0	0	0	0	0	0	1	16578	933	33	2		2	TRIM37	17	57125153	Silent	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	17480252	57125153	24070057	73	17761											
ZNF236	7776	broad.mit.edu	37	chr18	74611013	74611013	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcctcactgtgacaaaaaaTttcgaacctcaggccatagg	13	9	8	11	1	2	1	2	1	0	0	4	2	3	1	3	2	1	0	3	2	5	2			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr18:74611013T>A	uc002lmi.2	+	11	1921	c.1723T>A	c.(1723-1725)TTT>ATT	p.F575I	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	575	C2H2-type 13.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TGACAAAAAATTTCGAACCTC	0.383													5	63					0	0	0	0	A	74611013	A	A	74611013	3	1	90	1	0	0	0	0	1	0	0	0	17856	1493	52	5	1765	5	ZNF236	18	74611013	Missense_Mutation	SNP	T	TCGA-CQ-5323-01A-01D-1683-08		74611013	3466235	74	17762											
ZNF700	90592	broad.mit.edu	37	chr19	12058339	12058339	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtattttaggaaaaaaatgGagtgaccagaacattgaata	18	11	9	3	0	0	3	0	2	0	1	0	5	0	5	1	2	1	1	1	2	8	5			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr19:12058339G>C	uc002msu.2	+	3	327	c.201G>C	c.(199-201)TGG>TGC	p.W67C	ZNF700_uc010xme.1_Missense_Mutation_p.W85C|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	67	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAAAAAATGGAGTGACCAGA	0.358													3	89					0	0	0	0	C	12058339	C	C	12058339	3	2	90	1	0	0	0	0	1	0	0	0	18171	1183	41	2	211	2	ZNF700	19	12058339	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08		12058339	47070644	75	17763											
ZNF526	116115	broad.mit.edu	37	chr19	42728645	42728645	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacctatgtcggcagagatGatggagatgtcaacagaagt	14	8	12	7	1	1	4	1	1	0	3	2	6	1	4	1	2	1	1	1	2	3	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr19:42728645G>A	uc002osz.1	+	3	246	c.90G>A	c.(88-90)ATG>ATA	p.M30I		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	30					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				CGGCAGAGATGATGGAGATGT	0.557													5	85					0	0	0	0	A	42728645	A	A	42728645	3	1	90	1	0	0	0	0	1	0	0	0	18034	1290	45	2	92	2	ZNF526	19	42728645	Missense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	30670306	42728645	16400338	76	17764											
ZNF761	388561	broad.mit.edu	37	chr19	53959551	53959551	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaaaccttgaaatacatcAgaaaattcatactgaagaga	20	9	5	7	0	3	4	3	2	0	2	3	5	3	4	1	0	3	0	1	0	7	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr19:53959551A>G	uc010eqp.2	+	7	2248	c.1790A>G	c.(1789-1791)CAG>CGG	p.Q597R	ZNF761_uc010ydy.1_Missense_Mutation_p.Q543R|ZNF761_uc002qbt.1_Missense_Mutation_p.Q543R	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	597	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		GAAATACATCAGAAAATTCAT	0.408													24	60					0	0	0	0	G	53959551	G	G	53959551	3	3	90	1	0	0	0	0	1	0	0	0	18203	188	7	5	1801	5	ZNF761	19	53959551	Missense_Mutation	SNP	A	TCGA-CQ-5323-01A-01D-1683-08	11230906	53959551	5169432	77	17765											
SFRS15	57466	broad.mit.edu	37	chr21	33063194	33063194	+	Frame_Shift_Del	DEL	A	-	-																															gactttgtcccatggaatatAagtaacaccaagttctacat																										TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr21:33063194delA	uc002ypd.2	-	15	2227	c.1801delT	c.(1801-1803)TATfs	p.Y601fs	SFRS15_uc002ype.2_Frame_Shift_Del_p.Y601fs|SFRS15_uc010glu.2_Frame_Shift_Del_p.Y586fs|SFRS15_uc002ypf.1_Frame_Shift_Del_p.Y275fs	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	601						nucleus	nucleotide binding|RNA binding				0						CATGGAATATAAGTAACACCA	0.378													---	---	---								-	33063194	-	-	33063194	7	5	90	1	0	1	0	1	0	0	0	0	14236	362	13	0	1666	0	SFRS15	21	33063194	Frame_Shift_Del	DEL	A	TCGA-CQ-5323-01A-01D-1683-08		33063194	15066701	78	17766											
TBC1D10A	83874	broad.mit.edu	37	chr22	30688485	30688498	+	Frame_Shift_Del	DEL	ACATGCTGTGGGGG	-	-																															gggctgagtccttcgggggcAcatgctgtgggggacatgca																								rs61730760	byFrequency	TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr22:30688485_30688498delACATGCTGTGGGGG	uc011akt.1	-	11	1417_1430	c.1393_1406delCCCCCACAGCATGT	c.(1393-1407)CCCCCACAGCATGTGfs	p.P465fs	GATSL3_uc003ahc.2_5'Flank|GATSL3_uc003ahe.2_5'Flank|GATSL3_uc003ahd.2_5'Flank|GATSL3_uc003ahf.2_Intron|GATSL3_uc003ahg.2_Intron|GATSL3_uc003ahh.2_Intron|GATSL3_uc010gvq.2_Intron|GATSL3_uc003ahi.2_Intron|GATSL3_uc010gvr.2_5'Flank|GATSL3_uc010gvs.2_5'Flank|TBC1D10A_uc003ahj.3_Frame_Shift_Del_p.P377fs|TBC1D10A_uc010gvu.2_Frame_Shift_Del_p.P472fs|TBC1D10A_uc003ahk.3_Frame_Shift_Del_p.P465fs	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	465_469						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CTTCGGGGGCACATGCTGTGGGGGACATGCATCT	0.636													---	---	---								-	30688498	-	-	30688485	7	5	90	1	0	1	0	1	0	0	0	0	15664	159	6	0	124	0	TBC1D10A	22	30688485	Frame_Shift_Del	DEL	ACATGCTGTGGGGG	TCGA-CQ-5323-01A-01D-1683-08		30688485	20616081	79	17767											
TRIOBP	11078	broad.mit.edu	37	chr22	38119916	38119916	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagctacacgagacaacccCacaacatcctgtgcccagcg	13	4	8	16	2	0	2	0	0	0	2	1	3	1	2	4	0	6	1	4	0	3	1	rs55853304		TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr22:38119916C>T	uc003atr.2	+	7	1624	c.1353C>T	c.(1351-1353)CCC>CCT	p.P451P	TRIOBP_uc003atu.2_Silent_p.P279P|TRIOBP_uc003atq.1_Silent_p.P451P|TRIOBP_uc003ats.1_Silent_p.P279P	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	451					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GAGACAACCCCACAACATCCT	0.602													8	47					0	0	0	0	T	38119916	T	T	38119916	2	4	90	1	0	0	0	0	0	0	0	1	16620	581	21	4		4	TRIOBP	22	38119916	Silent	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	7431431	38119916	13184650	80	17768											
MKL1	57591	broad.mit.edu	37	chr22	40817050	40817050	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcacctttggcttcagctCcttggccttcttgctgcgct	2	16	8	15	1	3	0	2	0	1	0	4	0	4	0	3	2	3	4	3	2	0	6			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr22:40817050C>A	uc003ayv.1	-	7	889	c.682G>T	c.(682-684)GAG>TAG	p.E228*	MKL1_uc003ayw.1_Nonsense_Mutation_p.E228*|MKL1_uc010gye.1_Nonsense_Mutation_p.E228*|MKL1_uc010gyf.1_Nonsense_Mutation_p.E178*	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	228	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GGCTTCAGCTCCTTGGCCTTC	0.597			T	RBM15	acute megakaryocytic leukemia								6	77					8.12818e-05	8.65258e-05	1	0	A	40817050	A	A	40817050	4	1	90	1	0	0	0	0	0	1	0	0	9654	864	30	2	2137	2	MKL1	22	40817050	Nonsense_Mutation	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	2697134	40817050	10487516	81	17769											
SLC25A17	10478	broad.mit.edu	37	chr22	41173340	41173340	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtgccattccataaagcCgagattccttcatcgcgaat	12	11	7	11	3	1	1	1	0	0	1	4	3	3	1	4	0	2	0	4	0	4	4			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr22:41173340C>T	uc003azc.2	-	6	629	c.489G>A	c.(487-489)TCG>TCA	p.S163S	SLC25A17_uc010gyg.2_RNA|SLC25A17_uc011aou.1_Silent_p.S126S|SLC25A17_uc003azd.2_RNA|SLC25A17_uc011aov.1_Silent_p.S90S	NM_006358	NP_006349	O43808	PM34_HUMAN	solute carrier family 25 (mitochondrial carrier;	163	Solcar 2.|Helical; Name=4; (Potential).				fatty acid alpha-oxidation	integral to plasma membrane|mitochondrial inner membrane|peroxisomal membrane	adenine nucleotide transmembrane transporter activity|protein binding				0						TCCATAAAGCCGAGATTCCTT	0.408													13	26					0	0	0	0	T	41173340	T	T	41173340	2	4	90	1	0	0	0	0	0	0	0	1	14543	639	23	1		1	SLC25A17	22	41173340	Silent	SNP	C	TCGA-CQ-5323-01A-01D-1683-08	356290	41173340	10131226	82	17770											
SBF1	6305	broad.mit.edu	37	chr22	50903692	50903692	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggatgcgcacgacgtgcagGcaccagcgatagccctgcag	9	5	14	13	4	0	0	0	0	0	0	0	3	0	1	2	2	5	4	2	2	1	1			TCGA-CQ-5323-01A-01D-1683-08	TCGA-CQ-5323-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	892067ef-c465-46ea-8f91-10636dd0081b	66698a51-908a-483f-8e89-18fca752ec64	g.chr22:50903692G>T	uc003blh.2	-	11	1350	c.1155C>A	c.(1153-1155)TGC>TGA	p.C385*	SBF1_uc011arx.1_Nonsense_Mutation_p.C49*|SBF1_uc003bli.2_Nonsense_Mutation_p.C386*	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	385	dDENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CGACGTGCAGGCACCAGCGAT	0.642													4	7					2.56e-06	2.78505e-06	1	0	T	50903692	T	T	50903692	4	4	90	1	0	0	0	0	0	1	0	0	13923	1195	42	4	4650	4	SBF1	22	50903692	Nonsense_Mutation	SNP	G	TCGA-CQ-5323-01A-01D-1683-08	9730352	50903692	400874	83	17771											
C1orf89	79363	broad.mit.edu	37	chr1	16559457	16559457	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aactcaaaacgaaacatgacGacacggctgctggcctgcag	14	5	10	12	3	1	1	1	1	0	0	1	3	1	1	1	2	5	3	1	2	4	0			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:16559457G>A	uc001ayd.2	-	3	743	c.321C>T	c.(319-321)GTC>GTT	p.V107V		NM_030907	NP_112169	Q9BU20	RSG1_HUMAN	hypothetical protein LOC79363	107	Small GTPase-like.				cellular protein localization|cilium assembly|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|small GTPase mediated signal transduction	cilium|microtubule basal body	GTP binding				0		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.2e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;9.12e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		GAAACATGACGACACGGCTGC	0.577													22	58					0	0	0	0	A	16559457	A	A	16559457	2	1	91	1	0	0	0	0	0	0	0	1	2076	1045	37	1		1	C1orf89	1	16559457	Silent	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		16559457	232691164	1	17772											
AKR7L	246181	broad.mit.edu	37	chr1	19596120	19596120	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctcagtccaaagtgcctGaggcaggggaagagctccgt	11	6	13	11	1	1	2	1	1	0	1	3	3	3	3	4	3	3	2	4	3	3	0			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:19596120G>A	uc010ocx.1	-	5	561	c.561C>T	c.(559-561)CTC>CTT	p.L187L	AKR7L_uc010ocy.1_Intron	NM_201252	NP_957704			aflatoxin B1 aldehyde reductase 3 isoform 1												0						CAAAGTGCCTGAGGCAGGGGA	0.602													20	42					0	0	0	0	A	19596120	A	A	19596120	2	1	91	1	0	0	0	0	0	0	0	1	477	1277	45	2		2	AKR7L	1	19596120	Silent	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	3036663	19596120	229654501	2	17773											
MAP3K6	9064	broad.mit.edu	37	chr1	27682188	27682188	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgtagatgaggtcatctcGagtggcataggtgagcagag	10	9	17	5	1	2	4	1	2	1	2	3	5	2	4	0	4	1	3	0	4	2	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:27682188G>A	uc001bny.1	-	28	4009	c.3760C>T	c.(3760-3762)CGA>TGA	p.R1254*	MAP3K6_uc009vsw.1_Nonsense_Mutation_p.R1246*	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	1254					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AGGTCATCTCGAGTGGCATAG	0.512													9	71					0	0	0	0	A	27682188	A	A	27682188	4	1	91	1	0	0	0	0	0	1	0	0	9307	1066	37	1	114	1	MAP3K6	1	27682188	Nonsense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	8086068	27682188	221568433	3	17774											
MACF1	23499	broad.mit.edu	37	chr1	39812685	39812685	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggctgaaaggaaagctcagCtggatgctcttgcttttgat	9	13	12	7	0	2	2	1	2	1	0	2	4	2	4	0	3	4	5	0	3	2	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:39812685C>A	uc010oiu.1	+	5	6069	c.5938C>A	c.(5938-5940)CTG>ATG	p.L1980M	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3545					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAAGCTCAGCTGGATGCTCT	0.413													14	36					9.31168e-06	9.41631e-06	1	0	A	39812685	A	A	39812685	3	1	91	1	0	0	0	0	1	0	0	0	9195	796	28	4	10725	4	MACF1	1	39812685	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	12130497	39812685	209437936	4	17775											
YBX1	4904	broad.mit.edu	37	chr1	43166568	43166568	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcggtaccgccgcaacttcaAttaccgacgcagacgcccag	10	6	9	16	6	1	1	1	0	0	1	2	2	1	1	4	1	3	3	4	1	4	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:43166568A>G	uc001chs.2	+	7	1028	c.857A>G	c.(856-858)AAT>AGT	p.N286S		NM_004559	NP_004550	P67809	YBOX1_HUMAN	nuclease sensitive element binding protein 1	286					CRD-mediated mRNA stabilization|negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|positive regulation of cell division|transcription from RNA polymerase II promoter	CRD-mediated mRNA stability complex|extracellular region|histone pre-mRNA 3'end processing complex|nucleoplasm|stress granule|U12-type spliceosomal complex	double-stranded DNA binding|protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(4)|upper_aerodigestive_tract(1)	5	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CGCAACTTCAATTACCGACGC	0.527													12	33					0	0	0	0	G	43166568	G	G	43166568	3	3	91	1	0	0	0	0	1	0	0	0	17537	101	4	5	883	5	YBX1	1	43166568	Missense_Mutation	SNP	A	TCGA-CQ-5324-01A-01D-1683-08	3353883	43166568	206084053	5	17776											
TDRD10	126668	broad.mit.edu	37	chr1	154516537	154516537	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcggggctgctggtgaCgagtatcgtcccgaagaccc	7	6	17	11	4	0	2	0	1	0	1	2	5	1	3	2	5	1	3	2	5	2	1			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr1:154516537C>T	uc009wow.2	+	9	1440	c.602C>T	c.(601-603)ACG>ATG	p.T201M	TDRD10_uc001ffd.2_Missense_Mutation_p.T201M|TDRD10_uc001ffe.2_Missense_Mutation_p.T122M	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	201							nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTGCTGGTGACGAGTATCGTC	0.622													25	48					0	0	0	0	T	154516537	T	T	154516537	3	4	91	1	0	0	0	0	1	0	0	0	15797	536	19	1	632	1	TDRD10	1	154516537	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	111349969	154516537	94734084	6	17777											
NBAS	51594	broad.mit.edu	37	chr2	15557650	15557650	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaagttaaaataaaacctaCactattcatcagtaatctta	18	12	4	7	0	3	0	2	0	1	0	3	1	3	1	1	1	2	2	1	1	9	7			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:15557650C>A	uc002rcc.1	-	24	2789	c.2763_splice	c.e24+1	p.S921_splice	NBAS_uc010exl.1_Intron|NBAS_uc002rcd.1_Splice_Site	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein											ovary(2)|liver(1)|skin(1)	4						ATAAAACCTACACTATTCATC	0.323													13	20					0.000219431	0.000219431	1	0	A	15557650	A	A	15557650	5	1	91	1	0	0	0	0	0	0	1	0	10239	492	17	4	4467	4	NBAS	2	15557650	Splice_Site	SNP	C	TCGA-CQ-5324-01A-01D-1683-08		15557650	227641723	7	17778											
ITSN2	50618	broad.mit.edu	37	chr2	24471709	24471710	+	Frame_Shift_Ins	INS	-	T	T																															tcactactatacgtaccaggINSttttttatttgatgctccag																										TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:24471709_24471710insT	uc002rfe.2	-	26	3420_3421	c.3162_3163insA	c.(3160-3165)AAACCTfs	p.K1054fs	ITSN2_uc002rff.2_Frame_Shift_Ins_p.K1027fs|ITSN2_uc002rfg.2_Frame_Shift_Ins_p.K1054fs|ITSN2_uc002rfh.1_RNA	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1054_1055	SH3 4.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACGTACCAGGTTTTTTATTTG	0.342													---	---	---								T	24471710	T	T	24471709	7	5	91	1	0	1	1	0	0	0	0	0	7966	1261	44	0	2041	0	ITSN2	2	24471709	Frame_Shift_Ins	INS	-	TCGA-CQ-5324-01A-01D-1683-08	8914059	24471709	218727664	8	17779											
HK2	3099	broad.mit.edu	37	chr2	75116479	75116479	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtgcactgtggtggcccGgcgggcagcccagctctgtg	3	8	18	12	2	1	0	0	0	1	0	1	0	1	0	2	5	3	3	2	5	0	0	rs148653106		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:75116479G>A	uc002snd.2	+	17	4409	c.2483G>A	c.(2482-2484)CGG>CAG	p.R828Q		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	828	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GTGGTGGCCCGGCGGGCAGCC	0.607													10	17					0	0	0	0	A	75116479	A	A	75116479	3	1	91	1	0	0	0	0	1	0	0	0	7230	1116	39	1	2549	1	HK2	2	75116479	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	50644770	75116479	168082894	9	17780											
NFE2L2	4780	broad.mit.edu	37	chr2	178098956	178098956	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atacttctcgacttactccaAgatctatatcttgcctccaa	11	14	3	13	1	3	1	0	0	3	1	6	2	5	1	3	0	3	0	3	0	6	6			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:178098956A>T	uc002ulh.3	-	2	644	c.89T>A	c.(88-90)CTT>CAT	p.L30H	NFE2L2_uc002ulg.3_Missense_Mutation_p.L14H|NFE2L2_uc010zfa.1_Missense_Mutation_p.L14H|NFE2L2_uc002uli.3_Missense_Mutation_p.L14H|NFE2L2_uc010fra.2_Missense_Mutation_p.L14H|NFE2L2_uc010frb.2_Missense_Mutation_p.L14H	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	30					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ACTTACTCCAAGATCTATATC	0.363			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			19	15					0	0	0	0	T	178098956	T	T	178098956	3	4	91	1	0	0	0	0	1	0	0	0	10422	72	3	5	1744	5	NFE2L2	2	178098956	Missense_Mutation	SNP	A	TCGA-CQ-5324-01A-01D-1683-08	102982477	178098956	65100417	10	17781											
CASP8	841	broad.mit.edu	37	chr2	202131240	202131240	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagaaatctttatgatattGgggaacaactggacagtgaa	15	10	11	5	0	1	3	0	2	1	1	1	5	1	5	0	3	2	1	0	3	6	4			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:202131240G>A	uc002uxr.1	+	3	240	c.31G>A	c.(31-33)GGG>AGG	p.G11R	CASP8_uc010ftc.1_Missense_Mutation_p.G11R|CASP8_uc002uxo.1_Missense_Mutation_p.G11R|CASP8_uc002uxp.1_Missense_Mutation_p.G11R|CASP8_uc002uxq.1_Missense_Mutation_p.G11R|CASP8_uc002uxs.1_Missense_Mutation_p.G11R|CASP8_uc002uxt.1_Missense_Mutation_p.G70R|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.G11R|CASP8_uc002uxw.1_Missense_Mutation_p.G11R|CASP8_uc002uxy.1_Missense_Mutation_p.G11R|CASP8_uc002uxx.1_Missense_Mutation_p.G11R|CASP8_uc010ftf.2_Missense_Mutation_p.G11R	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	11	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding	p.G11R(1)		upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TTATGATATTGGGGAACAACT	0.403										HNSCC(4;0.00038)			33	17					0	0	0	0	A	202131240	A	A	202131240	3	1	91	1	0	0	0	0	1	0	0	0	2689	1348	47	4	214	4	CASP8	2	202131240	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	24032284	202131240	41068133	11	17782											
MPP4	58538	broad.mit.edu	37	chr2	202509991	202509991	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacccactgaggctcctccTgagccttctgtatggcagac	7	10	10	14	0	1	3	0	2	1	1	3	3	3	3	4	2	2	4	4	2	2	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr2:202509991T>A	uc002uyk.3	-	22	2064	c.1856A>T	c.(1855-1857)CAG>CTG	p.Q619L	ALS2CR4_uc002uyg.1_5'Flank|ALS2CR4_uc002uyh.1_5'Flank|MPP4_uc002uyi.3_Missense_Mutation_p.Q237L|MPP4_uc010ftj.2_Missense_Mutation_p.Q612L|MPP4_uc010zhq.1_Missense_Mutation_p.Q588L|MPP4_uc010zhr.1_Missense_Mutation_p.Q595L|MPP4_uc010zhs.1_Missense_Mutation_p.Q544L|MPP4_uc002uyj.3_Missense_Mutation_p.Q584L|MPP4_uc010zht.1_Missense_Mutation_p.Q561L|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Missense_Mutation_p.Q575L	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	619	Potential.					cytoplasm	protein binding				0						AGGCTCCTCCTGAGCCTTCTG	0.443													20	8					0	0	0	0	A	202509991	A	A	202509991	3	1	91	1	0	0	0	0	1	0	0	0	9789	1580	55	5	61	5	MPP4	2	202509991	Missense_Mutation	SNP	T	TCGA-CQ-5324-01A-01D-1683-08	378751	202509991	40689382	12	17783											
SETD2	29072	broad.mit.edu	37	chr3	47163754	47163754	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaagtacagtatatgtctGaatctttggttttgcagcaa	12	15	8	6	0	3	1	1	1	2	0	3	1	3	1	0	1	3	5	0	1	6	6			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr3:47163754G>C	uc003cqs.2	-	3	2425	c.2372C>G	c.(2371-2373)TCA>TGA	p.S791*	SETD2_uc003cqv.2_Nonsense_Mutation_p.S780*	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	791					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GTATATGTCTGAATCTTTGGT	0.358			N|F|S|Mis		clear cell renal carcinoma								24	47					0	0	0	0	C	47163754	C	C	47163754	4	2	91	1	0	0	0	0	0	1	0	0	14196	1294	45	2	5398	2	SETD2	3	47163754	Nonsense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		47163754	150858676	13	17784											
NPHP3	27031	broad.mit.edu	37	chr3	132423041	132423041	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aataatactccaagcacttaCtttctcaaatcccaactcat	15	12	1	13	0	2	0	2	0	1	0	5	0	4	0	2	0	4	1	2	0	7	4			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr3:132423041C>T	uc003epe.1	-	9	1601	c.1524_splice	c.e9+1	p.K508_splice	NPHP3_uc003epf.1_Splice_Site_p.K263_splice	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3						maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CAAGCACTTACTTTCTCAAAT	0.343													37	66					0	0	0	0	T	132423041	T	T	132423041	5	4	91	1	0	0	0	0	0	0	1	0	10634	579	20	4	2543	4	NPHP3	3	132423041	Splice_Site	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	85259287	132423041	65599389	14	17785											
FNDC3B	64778	broad.mit.edu	37	chr3	172003763	172003763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagacattctttcgggaataGagaaaccacaggtatgtctt	14	11	9	7	1	2	2	0	0	2	2	3	4	2	3	1	2	1	1	1	2	5	5			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr3:172003763G>A	uc003fhy.2	+	7	1010	c.838G>A	c.(838-840)GAG>AAG	p.E280K	FNDC3B_uc003fhz.3_Missense_Mutation_p.E280K|FNDC3B_uc003fia.2_Missense_Mutation_p.E211K	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	280	Fibronectin type-III 1.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TTCGGGAATAGAGAAACCACA	0.353													15	38					0	0	0	0	A	172003763	A	A	172003763	3	1	91	1	0	0	0	0	1	0	0	0	6002	943	33	2	860	2	FNDC3B	3	172003763	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	39580722	172003763	26018667	15	17786											
UGT2B10	7365	broad.mit.edu	37	chr4	69696413	69696413	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggattgaatttgtcatgcGccacaaaggagccaaacatc	13	9	9	10	1	1	1	1	1	0	0	2	3	1	3	2	2	3	0	2	2	3	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr4:69696413G>A	uc003hee.2	+	6	1428	c.1403G>A	c.(1402-1404)CGC>CAC	p.R468H	UGT2B10_uc011cam.1_Missense_Mutation_p.R384H	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	468					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TTTGTCATGCGCCACAAAGGA	0.448													39	60					0	0	0	0	A	69696413	A	A	69696413	3	1	91	1	0	0	0	0	1	0	0	0	17024	1087	38	1	1425	1	UGT2B10	4	69696413	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		69696413	121457863	16	17787											
ELF2	1998	broad.mit.edu	37	chr4	139980327	139980327	+	Frame_Shift_Del	DEL	T	-	-																															ccgatttaacctctggccccTttatgactgcactgataact																										TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr4:139980327delT	uc003ihp.1	-	9	1762	c.1556delA	c.(1555-1557)AAGfs	p.K519fs	ELF2_uc003ihm.1_Frame_Shift_Del_p.K471fs|ELF2_uc003ihn.1_Frame_Shift_Del_p.K459fs|ELF2_uc003iho.1_Frame_Shift_Del_p.K442fs|ELF2_uc011chc.1_Frame_Shift_Del_p.K334fs	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	531					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					CTCTGGCCCCTTTATGACTGC	0.448													---	---	---								-	139980327	-	-	139980327	7	5	91	1	0	1	0	1	0	0	0	0	5078	1609	56	0	193	0	ELF2	4	139980327	Frame_Shift_Del	DEL	T	TCGA-CQ-5324-01A-01D-1683-08	70283914	139980327	51173949	17	17788											
KLKB1	3818	broad.mit.edu	37	chr4	187171481	187171481	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccagatgcttttgtgtgtcGgaccatctgcacctatcacc	7	13	8	13	1	2	1	1	0	1	1	4	2	3	2	4	1	2	2	4	1	1	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr4:187171481G>A	uc003iyy.2	+	7	754	c.683G>A	c.(682-684)CGG>CAG	p.R228Q	KLKB1_uc011clc.1_Missense_Mutation_p.G16R|KLKB1_uc011cld.1_Missense_Mutation_p.R190Q	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	228	Apple 3.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TTTGTGTGTCGGACCATCTGC	0.463													26	67					0	0	0	0	A	187171481	A	A	187171481	3	1	91	1	0	0	0	0	1	0	0	0	8451	1116	39	1	705	1	KLKB1	4	187171481	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	47191154	187171481	3982795	18	17789											
UGT3A1	133688	broad.mit.edu	37	chr5	35955843	35955843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cataatttttggctactactCggaccatgtttccatgctgg	8	15	8	10	1	0	0	0	0	0	0	2	1	1	1	2	3	3	3	2	3	3	6			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:35955843C>T	uc003jjv.1	-	6	1356	c.1199G>A	c.(1198-1200)CGA>CAA	p.R400Q	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.R400Q|UGT3A1_uc011cor.1_Missense_Mutation_p.R366Q	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	400	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGCTACTACTCGGACCATGTT	0.483													23	50					0	0	0	0	T	35955843	T	T	35955843	3	4	91	1	0	0	0	0	1	0	0	0	17031	884	31	1	380	1	UGT3A1	5	35955843	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08		35955843	144959417	19	17790											
HCN1	348980	broad.mit.edu	37	chr5	45262411	45262411	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcacttcatttttcggcGtggagctgccaggtgtctgt	4	15	13	9	2	2	0	1	0	1	0	3	1	2	1	1	3	3	2	1	3	0	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:45262411G>A	uc003jok.2	-	8	2310	c.2285C>T	c.(2284-2286)ACG>ATG	p.T762M		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	762	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ATTTTTCGGCGTGGAGCTGCC	0.438													12	29					0	0	0	0	A	45262411	A	A	45262411	3	1	91	1	0	0	0	0	1	0	0	0	7035	1145	40	1	391	1	HCN1	5	45262411	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	9306568	45262411	135652849	20	17791											
RAD17	5884	broad.mit.edu	37	chr5	68682287	68682287	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaatagtgactatagaagctAacaaggtaagtctctgatta	16	11	9	5	0	1	3	0	2	1	1	2	4	1	3	0	1	2	2	0	1	9	6			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:68682287A>G	uc003jwo.2	+	8	984	c.922A>G	c.(922-924)AAC>GAC	p.N308D	RAD17_uc003jwg.2_Missense_Mutation_p.N297D|RAD17_uc003jwh.2_Missense_Mutation_p.N297D|RAD17_uc003jwi.2_Missense_Mutation_p.N297D|RAD17_uc003jwj.2_Missense_Mutation_p.N297D|RAD17_uc003jwk.2_Missense_Mutation_p.N297D|RAD17_uc003jwl.2_Missense_Mutation_p.N297D|RAD17_uc003jwm.2_Missense_Mutation_p.N132D|RAD17_uc003jwn.2_Missense_Mutation_p.N211D	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	308					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		TATAGAAGCTAACAAGGTAAG	0.284								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					8	16					0	0	0	0	G	68682287	G	G	68682287	3	3	91	1	0	0	0	0	1	0	0	0	13044	362	13	5	965	5	RAD17	5	68682287	Missense_Mutation	SNP	A	TCGA-CQ-5324-01A-01D-1683-08	23419876	68682287	112232973	21	17792											
IQGAP2	10788	broad.mit.edu	37	chr5	75991296	75991296	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggaggtagaccatgccacGgacatggtgagccgtgcaat	11	6	14	10	2	0	2	0	1	0	1	0	4	0	4	3	4	3	2	3	4	2	1			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:75991296G>A	uc003kek.2	+	32	4233	c.4011G>A	c.(4009-4011)ACG>ACA	p.T1337T	IQGAP2_uc011csv.1_Silent_p.T833T|IQGAP2_uc003kel.2_Silent_p.T833T|IQGAP2_uc010izw.1_Silent_p.T38T	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1337					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		ACCATGCCACGGACATGGTGA	0.433													12	27					0	0	0	0	A	75991296	A	A	75991296	2	1	91	1	0	0	0	0	0	0	0	1	7854	1103	39	1		1	IQGAP2	5	75991296	Silent	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	7309009	75991296	104923964	22	17793											
ARRDC3	57561	broad.mit.edu	37	chr5	90670932	90670932	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgtttggtaaatggctGcctttggcaccaccattcgg	6	13	11	11	1	0	0	0	0	0	0	1	0	0	0	4	4	1	4	4	4	2	4			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:90670932G>A	uc003kjz.2	-	5	917	c.677C>T	c.(676-678)GCA>GTA	p.A226V		NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	226					signal transduction	cytoplasm	protein binding			ovary(1)|breast(1)	2		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		GTAAATGGCTGCCTTTGGCAC	0.418													20	38					0	0	0	0	A	90670932	A	A	90670932	3	1	91	1	0	0	0	0	1	0	0	0	986	1319	46	4	583	4	ARRDC3	5	90670932	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	14679636	90670932	90244328	23	17794											
NDST1	3340	broad.mit.edu	37	chr5	149901143	149901143	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctggagtccagccgcttCaaataccgcacagagattgc	11	8	9	13	2	1	1	1	0	0	1	3	3	3	2	4	1	3	2	4	1	2	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:149901143C>T	uc003lsk.3	+	2	829	c.327C>T	c.(325-327)TTC>TTT	p.F109F	NDST1_uc011dcj.1_Silent_p.F109F|NDST1_uc003lsl.2_Silent_p.F109F	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	109	Heparan sulfate N-deacetylase 1.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAGCCGCTTCAAATACCGCA	0.612													25	80					0	0	0	0	T	149901143	T	T	149901143	2	4	91	1	0	0	0	0	0	0	0	1	10309	825	29	2		2	NDST1	5	149901143	Silent	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	59230211	149901143	31014117	24	17795											
GRIA1	2890	broad.mit.edu	37	chr5	153149755	153149755	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattgctgtgtttgagaagAtgtggacatacatgaagtca	14	12	11	4	0	1	3	1	2	0	2	1	5	1	4	0	1	2	2	0	1	4	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr5:153149755A>T	uc003lva.3	+	13	2415	c.2050A>T	c.(2050-2052)ATG>TTG	p.M684L	GRIA1_uc003luy.3_Missense_Mutation_p.M684L|GRIA1_uc003luz.3_Missense_Mutation_p.M589L|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.M604L|GRIA1_uc011dcx.1_Missense_Mutation_p.M615L|GRIA1_uc011dcy.1_Missense_Mutation_p.M694L|GRIA1_uc011dcz.1_Missense_Mutation_p.M694L	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	684	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GTTTGAGAAGATGTGGACATA	0.463													33	62					0	0	0	0	T	153149755	T	T	153149755	3	4	91	1	0	0	0	0	1	0	0	0	6806	333	12	5	2100	5	GRIA1	5	153149755	Missense_Mutation	SNP	A	TCGA-CQ-5324-01A-01D-1683-08	3248612	153149755	27765505	25	17796											
SNRNP48	154007	broad.mit.edu	37	chr6	7601664	7601664	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcttgccctctatgatttcGtagttgaggagacaaagaaa	12	12	10	7	1	2	4	0	2	2	2	3	5	2	4	1	1	1	2	1	1	4	5	rs141422613		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:7601664G>A	uc003mxr.2	+	5	561	c.502G>A	c.(502-504)GTA>ATA	p.V168I	SNRNP48_uc003mxs.2_RNA	NM_152551	NP_689764	Q6IEG0	SNR48_HUMAN	U11/U12 snRNP 48K	168					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0						CTATGATTTCGTAGTTGAGGA	0.378													23	32					0	0	0	0	A	7601664	A	A	7601664	3	1	91	1	0	0	0	0	1	0	0	0	14921	1145	40	1	520	1	SNRNP48	6	7601664	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		7601664	163513403	26	17797											
HLA-B	3106	broad.mit.edu	37	chr6	31323136	31323137	+	Frame_Shift_Ins	INS	-	ATGG	ATGG																															ggcagcccctcatgctgtacINSatggcatgtgtatctctgct																								rs41551415		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:31323136_31323137insATGG	uc003nth.2	-	4	906_907	c.852_853insCCAT	c.(850-855)CATGTAfs	p.H284fs	HLA-C_uc003ntb.2_RNA|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_RNA|HLA-B_uc011dnk.1_RNA|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Frame_Shift_Ins_p.H163fs|HLA-B_uc003nti.1_RNA|HLA-B_uc010jsn.1_RNA	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	284_285	Alpha-3.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						TCATGCTGTACATGGCATGTGT	0.564									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				---	---	---								ATGG	31323137	ATGG	ATGG	31323136	7	5	91	1	0	1	1	0	0	0	0	0	7235	478	17	0	251	0	HLA-B	6	31323136	Frame_Shift_Ins	INS	-	TCGA-CQ-5324-01A-01D-1683-08	23721472	31323136	139791931	27	17798											
HLA-DQA2	3118	broad.mit.edu	37	chr6	32714066	32714066	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcacagagactttggtctgCgccctggggttgtctgtggg	4	12	15	10	1	3	1	1	0	2	1	3	2	3	1	1	4	1	1	1	4	0	2	rs143176293		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:32714066C>T	uc003obx.2	+	4	721	c.663C>T	c.(661-663)TGC>TGT	p.C221C		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	221	Helical; (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTTGGTCTGCGCCCTGGGGT	0.552													28	57					0	0	0	0	T	32714066	T	T	32714066	2	4	91	1	0	0	0	0	0	0	0	1	7244	776	27	1		1	HLA-DQA2	6	32714066	Silent	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	1390930	32714066	138401001	28	17799											
ZNF318	24149	broad.mit.edu	37	chr6	43306213	43306213	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtttcacttcctgtcatCaatttattggactgttcagc	8	16	8	9	0	4	0	4	0	0	0	5	2	5	2	1	2	1	2	1	2	2	6			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:43306213C>A	uc003oux.2	-	10	5601	c.5523G>T	c.(5521-5523)TTG>TTT	p.L1841F	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1841					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TTCCTGTCATCAATTTATTGG	0.378													28	39					2.48779e-11	2.66549e-11	1	0	A	43306213	A	A	43306213	3	1	91	1	0	0	0	0	1	0	0	0	17903	825	29	2	1320	2	ZNF318	6	43306213	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	10592147	43306213	127808854	29	17800											
C6orf138	442213	broad.mit.edu	37	chr6	47846396	47846396	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaaaagcagtggtgcacaGtggtcaatggcgaaattcaa	14	8	13	6	1	2	1	2	1	0	0	2	2	2	1	0	3	2	2	0	3	5	1			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:47846396G>A	uc011dwm.1	-	3	2218	c.2133C>T	c.(2131-2133)CAC>CAT	p.H711H	C6orf138_uc011dwn.1_Silent_p.H475H	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	728	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						GTGGTGCACAGTGGTCAATGG	0.438													8	11					0	0	0	0	A	47846396	A	A	47846396	2	1	91	1	0	0	0	0	0	0	0	1	2342	1020	36	4		4	C6orf138	6	47846396	Silent	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	4540183	47846396	123268671	30	17801											
DST	667	broad.mit.edu	37	chr6	56496014	56496017	+	Frame_Shift_Del	DEL	TATG	-	-																															atagcagttacatacttatcTatgtaagtggaagacataga																										TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:56496014_56496017delTATG	uc003pdf.2	-	29	4063_4066	c.4035_4038delCATA	c.(4033-4038)TACATAfs	p.Y1345fs	DST_uc003pcz.3_Frame_Shift_Del_p.Y1167fs|DST_uc011dxj.1_Frame_Shift_Del_p.Y1196fs|DST_uc011dxk.1_Frame_Shift_Del_p.Y1207fs|DST_uc003pcy.3_Frame_Shift_Del_p.Y841fs|DST_uc003pdb.2_Frame_Shift_Del_p.Y841fs|DST_uc003pdc.3_Frame_Shift_Del_p.Y841fs|DST_uc003pdd.3_Frame_Shift_Del_p.Y841fs	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1167_1168					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CATACTTATCTATGTAAGTGGAAG	0.299													---	---	---								-	56496017	-	-	56496014	7	5	91	1	0	1	0	1	0	0	0	0	4805	1512	53	0	17905	0	DST	6	56496014	Frame_Shift_Del	DEL	TATG	TCGA-CQ-5324-01A-01D-1683-08	8649618	56496014	114619053	31	17802											
DST	667	broad.mit.edu	37	chr6	56496801	56496802	+	Frame_Shift_Del	DEL	AG	-	-																															agtctaatgtttcgaacttcAgagatgtagagattataaac																										TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:56496801_56496802delAG	uc003pdf.2	-	28	3771_3772	c.3743_3744delCT	c.(3742-3744)TCTfs	p.S1248fs	DST_uc003pcz.3_Frame_Shift_Del_p.S1070fs|DST_uc011dxj.1_Frame_Shift_Del_p.S1099fs|DST_uc011dxk.1_Frame_Shift_Del_p.S1110fs|DST_uc003pcy.3_Frame_Shift_Del_p.S744fs|DST_uc003pdb.2_Frame_Shift_Del_p.S744fs|DST_uc003pdc.3_Frame_Shift_Del_p.S744fs|DST_uc003pdd.3_Frame_Shift_Del_p.S744fs	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1070					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTCGAACTTCAGAGATGTAGAG	0.361													---	---	---								-	56496802	-	-	56496801	7	5	91	1	0	1	0	1	0	0	0	0	4805	175	7	0	18203	0	DST	6	56496801	Frame_Shift_Del	DEL	AG	TCGA-CQ-5324-01A-01D-1683-08	787	56496801	114618266	32	17803											
DOPEY1	23033	broad.mit.edu	37	chr6	83845504	83845504	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcagagggtttcagtacagCgtgtacaagcagaacgttat	12	10	11	8	2	2	2	2	0	0	2	2	2	2	2	0	1	5	5	0	1	5	4			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:83845504C>T	uc003pjs.1	+	20	3297	c.3037C>T	c.(3037-3039)CGT>TGT	p.R1013C	DOPEY1_uc011dyy.1_Missense_Mutation_p.R1004C|DOPEY1_uc010kbl.1_Missense_Mutation_p.R1004C|DOPEY1_uc003pjt.2_5'Flank	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1013					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTCAGTACAGCGTGTACAAGC	0.433													40	62					0	0	0	0	T	83845504	T	T	83845504	3	4	91	1	0	0	0	0	1	0	0	0	4729	768	27	1	3107	1	DOPEY1	6	83845504	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	27348703	83845504	87269563	33	17804											
LATS1	9113	broad.mit.edu	37	chr6	150005729	150005729	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgattgctgcacattccCtatggttataagagagataa	14	12	8	7	0	0	3	0	1	0	2	1	4	1	3	1	1	3	3	1	1	5	6	rs34361382		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr6:150005729C>T	uc003qmu.1	-	4	1045	c.497_splice	c.e4-1	p.G166_splice	LATS1_uc010kif.1_Splice_Site_p.G61_splice|LATS1_uc003qmv.1_Splice_Site_p.G166_splice|LATS1_uc003qmw.2_Intron|LATS1_uc010kig.1_Intron	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1						cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		TGCACATTCCCTATGGTTATA	0.383													18	33					0	0	0	0	T	150005729	T	T	150005729	5	4	91	1	0	0	0	0	0	0	1	0	8686	695	24	4	2916	4	LATS1	6	150005729	Splice_Site	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	66160225	150005729	21109338	34	17805											
C7orf57	136288	broad.mit.edu	37	chr7	48080963	48080963	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtcccagtgaagcgctctGagaaggccgtggatgcccca	9	6	13	13	3	1	2	0	2	1	1	2	4	2	3	4	2	2	1	4	2	2	0			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr7:48080963G>A	uc003toh.3	+	3	300	c.88G>A	c.(88-90)GAG>AAG	p.E30K	C7orf57_uc003toi.3_5'UTR	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	30										ovary(1)	1						GAAGCGCTCTGAGAAGGCCGT	0.587													9	25					0	0	0	0	A	48080963	A	A	48080963	3	1	91	1	0	0	0	0	1	0	0	0	2415	1291	45	2	94	2	C7orf57	7	48080963	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		48080963	111057700	35	17806											
GRM3	2913	broad.mit.edu	37	chr7	86415775	86415775	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagcctccgagggtgattacGgggagacagggatcgaggcc	9	6	17	9	3	0	2	0	1	0	1	2	6	1	3	3	5	2	0	3	5	2	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr7:86415775G>A	uc003uid.2	+	3	1766	c.667G>A	c.(667-669)GGG>AGG	p.G223R	GRM3_uc010lef.2_Missense_Mutation_p.G221R|GRM3_uc010leg.2_Missense_Mutation_p.G95R|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	223	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGGTGATTACGGGGAGACAGG	0.612													26	42					0	0	0	0	A	86415775	A	A	86415775	3	1	91	1	0	0	0	0	1	0	0	0	6837	1116	39	1	673	1	GRM3	7	86415775	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	38334812	86415775	72722888	36	17807											
PTDSS1	9791	broad.mit.edu	37	chr8	97311963	97311963	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccaattttgccgagtgctgGtgggatcaagtcattctgga	8	12	12	9	1	3	0	2	0	1	0	3	3	3	2	2	3	2	1	2	3	2	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr8:97311963G>A	uc003yht.1	+	6	744	c.642G>A	c.(640-642)TGG>TGA	p.W214*	PTDSS1_uc003yhu.1_Nonsense_Mutation_p.W68*	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	214					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	CCGAGTGCTGGTGGGATCAAG	0.493													47	68					0	0	0	0	A	97311963	A	A	97311963	4	1	91	1	0	0	0	0	0	1	0	0	12798	1270	44	4	664	4	PTDSS1	8	97311963	Nonsense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		97311963	49052059	37	17808											
FLJ46321	389763	broad.mit.edu	37	chr9	84609395	84609395	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggtgcttgggagcaaatcttCcccaaccttgaaaacacagc	12	8	9	12	0	1	1	0	1	1	0	2	2	2	2	3	2	5	2	3	2	4	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr9:84609395C>G	uc004amn.2	+	4	4057	c.4010C>G	c.(4009-4011)TCC>TGC	p.S1337C		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1337						integral to membrane					0						AGCAAATCTTCCCCAACCTTG	0.478													5	9					0	0	0	0	G	84609395	G	G	84609395	3	3	91	1	0	0	0	0	1	0	0	0	5964	855	30	2	4024	2	FLJ46321	9	84609395	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08		84609395	56604036	38	17809											
CCNJ	54619	broad.mit.edu	37	chr10	97817643	97817643	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagggcaagcaggacctcAgtcagcgcaactaagtgtat	13	6	13	9	1	2	1	2	0	0	1	2	3	2	2	1	2	3	4	1	2	4	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr10:97817643A>G	uc001klm.2	+	6	1123	c.764A>G	c.(763-765)CAG>CGG	p.Q255R	uc001klg.1_Intron|uc001klj.1_Intron|uc009xvb.1_Intron|CCNJ_uc010qoq.1_Missense_Mutation_p.Q266R|CCNJ_uc001kln.2_Missense_Mutation_p.Q254R	NM_019084	NP_061957	Q5T5M9	CCNJ_HUMAN	cyclin J isoform 2	255						nucleus				ovary(1)	1				Epithelial(162;6.1e-08)|all cancers(201;2.32e-06)		GCAGGACCTCAGTCAGCGCAA	0.468													31	17					0	0	0	0	G	97817643	G	G	97817643	3	3	91	1	0	0	0	0	1	0	0	0	2943	188	7	5	815	5	CCNJ	10	97817643	Missense_Mutation	SNP	A	TCGA-CQ-5324-01A-01D-1683-08		97817643	37717104	39	17810											
HRAS	3265	broad.mit.edu	37	chr11	534285	534285	+	Missense_Mutation	SNP	C	A	A																															tcagcgcactcttgcccacaCcgccggcgcccaccaccacc																								rs104894226		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr11:534285C>A	uc001lpv.2	-	2	226	c.38G>T	c.(37-39)GGT>GTT	p.G13V	HRAS_uc010qvw.1_Missense_Mutation_p.G13V|HRAS_uc010qvx.1_Missense_Mutation_p.G13V|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	13	GTP.		G -> D (in FCSS).|G -> C (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(33)|p.G13V(10)|p.G13D(9)|p.G13S(9)|p.G13C(6)|p.G13G(1)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CTTGCCCACACCGCCGGCGCC	0.642		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			21	12					1.9806e-07	2.04889e-07	1	0	A	534285	A	A	534285	3	1	91	1	0	0	0	0	1	0	0	0	7387	507	18	4	614	4	HRAS	11	534285	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08		534285	134472231	40	17811	37	2									
HRAS	3265	broad.mit.edu	37	chr11	534291	534291	+	Missense_Mutation	SNP	G	T	T																															cactcttgcccacaccgccgGcgcccaccaccaccagctta																										TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr11:534291G>T	uc001lpv.2	-	2	220	c.32C>A	c.(31-33)GCC>GAC	p.A11D	HRAS_uc010qvw.1_Missense_Mutation_p.A11D|HRAS_uc010qvx.1_Missense_Mutation_p.A11D|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	11	GTP.				activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.A11A(2)|p.G10_A11insG(1)|p.A11S(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CACACCGCCGGCGCCCACCAC	0.652		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			19	11					3.99206e-14	4.38153e-14	1	0	T	534291	T	T	534291	3	4	91	1	0	0	0	0	1	0	0	0	7387	1203	42	4	620	4	HRAS	11	534291	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	6	534291	134472225	41	17812	37	2									
DNHD1	144132	broad.mit.edu	37	chr11	6593070	6593070	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccgacctgactgtgtacTcgtgtcctgtgtacatggga	7	11	12	11	2	0	1	0	1	0	0	2	3	1	2	3	1	3	2	3	1	2	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr11:6593070T>A	uc001mdw.3	+	43	14680	c.14116T>A	c.(14116-14118)TCG>ACG	p.S4706T	DNHD1_uc001mea.3_Missense_Mutation_p.S975T|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Missense_Mutation_p.S974T|DNHD1_uc010rao.1_Missense_Mutation_p.S964T|DNHD1_uc009yfg.2_Missense_Mutation_p.S331T	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4706					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GACTGTGTACTCGTGTCCTGT	0.627													13	54					0	0	0	0	A	6593070	A	A	6593070	3	1	91	1	0	0	0	0	1	0	0	0	4690	1551	54	5	14287	5	DNHD1	11	6593070	Missense_Mutation	SNP	T	TCGA-CQ-5324-01A-01D-1683-08	6058779	6593070	128413446	42	17813											
ANO5	203859	broad.mit.edu	37	chr11	22276979	22276979	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggaatatgaatgggacctgGtggactttgaagaggaacag	13	9	15	4	0	0	3	0	2	0	1	0	7	0	7	1	5	1	0	1	5	5	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr11:22276979G>C	uc001mqi.2	+	13	1560	c.1243G>C	c.(1243-1245)GTG>CTG	p.V415L	ANO5_uc001mqj.2_Missense_Mutation_p.V414L	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	415	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						ATGGGACCTGGTGGACTTTGA	0.358													52	82					0	0	0	0	C	22276979	C	C	22276979	3	2	91	1	0	0	0	0	1	0	0	0	700	1261	44	4	1293	4	ANO5	11	22276979	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	15683909	22276979	112729537	43	17814											
MARK2	2011	broad.mit.edu	37	chr11	63668102	63668102	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccacggactgtgaaaacctGcttaagaaatttctcattct	12	13	6	10	1	2	2	1	1	2	1	4	3	3	3	2	1	2	1	2	1	4	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr11:63668102G>A	uc001nxw.2	+	9	1419	c.840G>A	c.(838-840)CTG>CTA	p.L280L	MARK2_uc001nxx.2_Silent_p.L280L|MARK2_uc001nxy.2_Silent_p.L280L|MARK2_uc001nxv.3_Silent_p.L280L|MARK2_uc001nxz.3_Silent_p.L247L|MARK2_uc009yoy.2_Silent_p.L247L	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	280	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						GTGAAAACCTGCTTAAGAAAT	0.507													97	180					0	0	0	0	A	63668102	A	A	63668102	2	1	91	1	0	0	0	0	0	0	0	1	9366	1306	46	4		4	MARK2	11	63668102	Silent	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	41391123	63668102	71338414	44	17815											
ADAMTS20	80070	broad.mit.edu	37	chr12	43826253	43826253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcgagacctttcccctcCtccacaactcctggaacact	8	11	4	18	1	1	1	0	0	1	1	6	3	5	2	6	1	2	0	6	1	2	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr12:43826253C>T	uc010skx.1	-	21	2950	c.2950G>A	c.(2950-2952)GGA>AGA	p.G984R	ADAMTS20_uc001rno.1_Missense_Mutation_p.G138R|ADAMTS20_uc001rnp.1_Missense_Mutation_p.G138R	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	984	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTTTCCCCTCCTCCACAACTC	0.368													18	35					0	0	0	0	T	43826253	T	T	43826253	3	4	91	1	0	0	0	0	1	0	0	0	266	690	24	4	2857	4	ADAMTS20	12	43826253	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08		43826253	90025642	45	17816											
LRP1	4035	broad.mit.edu	37	chr12	57601972	57601972	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcatgattgacgagccccAcgccattgtggtggacccac	8	7	13	13	2	0	2	0	2	0	0	0	4	0	3	4	3	1	1	4	3	0	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr12:57601972A>G	uc001snd.2	+	77	12477	c.12011A>G	c.(12010-12012)CAC>CGC	p.H4004R		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4004	LDL-receptor class B 32.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GACGAGCCCCACGCCATTGTG	0.657													7	12					0	0	0	0	G	57601972	G	G	57601972	3	3	91	1	0	0	0	0	1	0	0	0	9001	159	6	5	12317	5	LRP1	12	57601972	Missense_Mutation	SNP	A	TCGA-CQ-5324-01A-01D-1683-08	13775719	57601972	76249923	46	17817											
PAN3	255967	broad.mit.edu	37	chr13	28771372	28771372	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaggctagttccgatgggAtcaaaggcacgaaaagcaaa	16	5	13	7	2	1	1	1	0	0	1	2	5	2	2	1	3	1	4	1	3	5	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr13:28771372A>T	uc001urz.2	+	4	311	c.303A>T	c.(301-303)GGA>GGT	p.G101G	PAN3_uc010tdo.1_Silent_p.G247G|PAN3_uc001ury.2_5'UTR|PAN3_uc001urx.2_Intron	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	247	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TTCCGATGGGATCAAAGGCAC	0.493													5	7					0	0	0	0	T	28771372	T	T	28771372	2	4	91	1	0	0	0	0	0	0	0	1	11469	320	12	5		5	PAN3	13	28771372	Silent	SNP	A	TCGA-CQ-5324-01A-01D-1683-08		28771372	86398506	47	17818											
DNAJC15	29103	broad.mit.edu	37	chr13	43597852	43597852	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaaacggccagacgccgaCgtcgaccagcagagactggt	11	3	13	14	5	0	2	0	0	0	2	1	5	0	2	4	2	2	1	4	2	1	0			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr13:43597852C>T	uc001uyy.2	+	1	491	c.90C>T	c.(88-90)GAC>GAT	p.D30D		NM_013238	NP_037370	Q9Y5T4	DJC15_HUMAN	DNAJ domain-containing	30						integral to membrane	heat shock protein binding				0		Lung NSC(96;4.3e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0737)		CAGACGCCGACGTCGACCAGC	0.642													4	9					0	0	0	0	T	43597852	T	T	43597852	2	4	91	1	0	0	0	0	0	0	0	1	4656	535	19	1		1	DNAJC15	13	43597852	Silent	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	14826480	43597852	71572026	48	17819											
ATP4B	496	broad.mit.edu	37	chr13	114304774	114304774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagactgaaggtgccgttggGagggtagtacttgacctgca	9	9	15	8	1	0	3	0	2	0	1	0	4	0	4	2	3	3	4	2	3	3	4			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr13:114304774G>A	uc001vtz.2	-	6	703	c.661C>T	c.(661-663)CCC>TCC	p.P221S		NM_000705	NP_000696	P51164	ATP4B_HUMAN	hydrogen/potassium-exchanging ATPase 4B	221	Extracellular (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	hydrogen:potassium-exchanging ATPase activity|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.171)		Rabeprazole(DB01129)	GTGCCGTTGGGAGGGTAGTAC	0.622													24	37					0	0	0	0	A	114304774	A	A	114304774	3	1	91	1	0	0	0	0	1	0	0	0	1148	1174	41	2	222	2	ATP4B	13	114304774	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	70706922	114304774	865104	49	17820											
TPPP2	122664	broad.mit.edu	37	chr14	21499180	21499180	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taactgaccagggccaagaaCgcccgaaccatcacgtttca	13	6	8	14	3	2	2	2	1	0	1	2	3	2	2	4	1	3	1	4	1	4	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr14:21499180C>T	uc001vzh.2	+	3	371	c.183C>T	c.(181-183)AAC>AAT	p.N61N	NDRG2_uc010tll.1_Intron	NM_173846	NP_776245	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family	61						cytoplasm					0	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GGGCCAAGAACGCCCGAACCA	0.483													12	23					0	0	0	0	T	21499180	T	T	21499180	2	4	91	1	0	0	0	0	0	0	0	1	16481	535	19	1		1	TPPP2	14	21499180	Silent	SNP	C	TCGA-CQ-5324-01A-01D-1683-08		21499180	85850360	50	17821											
TINF2	26277	broad.mit.edu	37	chr14	24709835	24709835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagggaaacagcatgactGtggggcgctccttatggcct	10	9	13	9	1	0	1	0	1	0	0	1	2	1	2	2	4	2	2	2	4	4	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr14:24709835G>A	uc001woa.3	-	6	1193	c.851C>T	c.(850-852)ACA>ATA	p.T284I	TINF2_uc010alm.2_Missense_Mutation_p.T108I|TINF2_uc001wob.3_Missense_Mutation_p.T284I|TINF2_uc010tof.1_Missense_Mutation_p.T249I|TINF2_uc001woc.3_3'UTR	NM_001099274	NP_001092744	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	284					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|protein binding|telomeric DNA binding				0				GBM - Glioblastoma multiforme(265;0.0185)		CAGCATGACTGTGGGGCGCTC	0.552									Ataxia_Pancytopenia_syndrome|Congenital_Dyskeratosis				17	28					0	0	0	0	A	24709835	A	A	24709835	3	1	91	1	0	0	0	0	1	0	0	0	15989	1377	48	4	524	4	TINF2	14	24709835	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	3210655	24709835	82639705	51	17822											
TP53BP1	7158	broad.mit.edu	37	chr15	43720231	43720231	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctcagttacttttctttCtacttctgttccatccacat	7	19	2	13	0	4	0	1	0	3	0	6	0	6	0	3	0	3	2	3	0	3	8			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr15:43720231C>T	uc001zrs.2	-	18	3944	c.3796G>A	c.(3796-3798)GAA>AAA	p.E1266K	TP53BP1_uc010udp.1_Missense_Mutation_p.E1266K|TP53BP1_uc001zrq.3_Missense_Mutation_p.E1271K|TP53BP1_uc001zrr.3_Missense_Mutation_p.E1271K|TP53BP1_uc010udq.1_Missense_Mutation_p.E1271K	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1266					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		ACTTTTCTTTCTACTTCTGTT	0.308								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					39	90					0	0	0	0	T	43720231	T	T	43720231	3	4	91	1	0	0	0	0	1	0	0	0	16450	922	32	2	2166	2	TP53BP1	15	43720231	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08		43720231	58811161	52	17823											
SEC11A	23478	broad.mit.edu	37	chr15	85230875	85230875	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttcatgaatcttcaagaCtcggtgaactataggaatct	12	14	7	8	1	4	3	2	2	2	1	5	4	4	4	0	2	1	0	0	2	6	5			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr15:85230875C>G	uc002blb.1	-	3	660	c.292G>C	c.(292-294)GTC>CTC	p.V98L	SEC11A_uc002blc.1_Missense_Mutation_p.V72L	NM_014300	NP_055115	P67812	SC11A_HUMAN	SEC11-like 1	98	Lumenal (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	protein binding|serine-type peptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(143;0.199)			ATCTTCAAGACTCGGTGAACT	0.343													21	75					0	0	0	0	G	85230875	G	G	85230875	3	3	91	1	0	0	0	0	1	0	0	0	14043	565	20	4	263	4	SEC11A	15	85230875	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	41510644	85230875	17300517	53	17824											
CACNA1H	8912	broad.mit.edu	37	chr16	1265063	1265063	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggtagcatttgggttccGtcggttcttcaaggacaggt	6	13	14	8	2	2	0	1	0	1	0	4	1	3	1	1	5	1	5	1	5	2	5			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr16:1265063G>A	uc002cks.2	+	28	5269	c.5021G>A	c.(5020-5022)CGT>CAT	p.R1674H	CACNA1H_uc002ckt.2_Missense_Mutation_p.R1668H|CACNA1H_uc002cku.2_Missense_Mutation_p.R380H|CACNA1H_uc010brj.2_Missense_Mutation_p.R385H|CACNA1H_uc002ckv.2_Missense_Mutation_p.R374H	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1674	IV.|Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TTTGGGTTCCGTCGGTTCTTC	0.622													7	10					0	0	0	0	A	1265063	A	A	1265063	3	1	91	1	0	0	0	0	1	0	0	0	2557	1145	40	1	5127	1	CACNA1H	16	1265063	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		1265063	89089690	54	17825											
TBC1D24	57465	broad.mit.edu	37	chr16	2546268	2546268	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaactgaagcagctggcgcGccagggctactgggcccaaa	10	4	15	12	2	0	1	0	1	0	0	0	2	0	2	2	4	4	3	2	4	4	1			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr16:2546268G>A	uc002cql.2	+	2	259	c.119G>A	c.(118-120)CGC>CAC	p.R40H	TBC1D24_uc002cqk.2_Missense_Mutation_p.R40H|TBC1D24_uc002cqm.2_Missense_Mutation_p.R40H|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	40					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						CAGCTGGCGCGCCAGGGCTAC	0.642													13	31					0	0	0	0	A	2546268	A	A	2546268	3	1	91	1	0	0	0	0	1	0	0	0	15680	1087	38	1	121	1	TBC1D24	16	2546268	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	1281205	2546268	87808485	55	17826											
GRIN2A	2903	broad.mit.edu	37	chr16	9943686	9943686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggggtctatgtcttccaCgatgacgaatggggcctcct	7	10	13	11	2	2	1	0	1	2	0	4	3	4	1	3	4	0	0	3	4	2	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr16:9943686C>T	uc002czo.3	-	5	1803	c.1255G>A	c.(1255-1257)GTG>ATG	p.V419M	GRIN2A_uc010uym.1_Missense_Mutation_p.V419M|GRIN2A_uc010uyn.1_Missense_Mutation_p.V262M|GRIN2A_uc002czr.3_Missense_Mutation_p.V419M	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	419	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGTCTTCCACGATGACGAAT	0.572													24	45					0	0	0	0	T	9943686	T	T	9943686	3	4	91	1	0	0	0	0	1	0	0	0	6818	536	19	1	3175	1	GRIN2A	16	9943686	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	7397418	9943686	80411067	56	17827											
ZFHX3	463	broad.mit.edu	37	chr16	72993515	72993515	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccccttgcttgccccccGcgccagggagagagttcagg	5	7	14	15	2	1	1	1	0	0	1	2	3	2	2	6	3	2	2	6	3	0	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr16:72993515G>A	uc002fck.2	-	2	1203	c.530C>T	c.(529-531)GCG>GTG	p.A177V	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	177					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CTTGCCCCCCGCGCCAGGGAG	0.637													12	44					0	0	0	0	A	72993515	A	A	72993515	3	1	91	1	0	0	0	0	1	0	0	0	17701	1087	38	1	10617	1	ZFHX3	16	72993515	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	63049829	72993515	17361238	57	17828											
NEK8	284086	broad.mit.edu	37	chr17	27067575	27067575	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagcgagttgtatgtggtatCgattcctccatgatcctcac	8	13	9	11	2	1	1	1	1	0	0	5	3	4	1	3	1	1	3	3	1	2	4			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr17:27067575C>G	uc002hcp.2	+	11	1512	c.1512C>G	c.(1510-1512)ATC>ATG	p.I504M		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	504	RCC1 3.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					TATGTGGTATCGATTCCTCCA	0.587													28	43					0	0	0	0	G	27067575	G	G	27067575	3	3	91	1	0	0	0	0	1	0	0	0	10384	874	31	3	1554	3	NEK8	17	27067575	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08		27067575	54127635	58	17829											
NF1	4763	broad.mit.edu	37	chr17	29657375	29657375	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaatttaaaaatcgagggcCagttactagagacatcaggt	15	11	9	6	1	1	1	1	0	0	1	2	3	1	1	1	2	1	1	1	2	6	5			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr17:29657375C>T	uc002hgg.2	+	39	6004	c.5671C>T	c.(5671-5673)CAG>TAG	p.Q1891*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q1870*|NF1_uc002hgi.1_Nonsense_Mutation_p.Q903*|NF1_uc010cso.2_Nonsense_Mutation_p.Q79*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1891					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AATCGAGGGCCAGTTACTAGA	0.398			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			5	69					0	0	0	0	T	29657375	T	T	29657375	4	4	91	1	0	0	0	0	0	1	0	0	10410	595	21	4	5886	4	NF1	17	29657375	Nonsense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	2589800	29657375	51537835	59	17830											
NPEPPS	9520	broad.mit.edu	37	chr17	45663002	45663002	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagaaacaaggtcaaaagAtggtgtgtgtgtccgtgttt	11	13	13	4	1	1	2	1	0	0	2	2	2	2	2	1	2	1	2	1	2	5	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr17:45663002A>G	uc002ilr.3	+	6	1008	c.785A>G	c.(784-786)GAT>GGT	p.D262G	NPEPPS_uc010wkt.1_Missense_Mutation_p.D258G|NPEPPS_uc010wku.1_Missense_Mutation_p.D226G|NPEPPS_uc010dba.1_Missense_Mutation_p.D107G|NPEPPS_uc010wkv.1_5'Flank	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	262					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						AGGTCAAAAGATGGTGTGTGT	0.418													45	101					0	0	0	0	G	45663002	G	G	45663002	3	3	91	1	0	0	0	0	1	0	0	0	10629	333	12	5	807	5	NPEPPS	17	45663002	Missense_Mutation	SNP	A	TCGA-CQ-5324-01A-01D-1683-08	16005627	45663002	35532208	60	17831											
USP32	84669	broad.mit.edu	37	chr17	58257980	58257980	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agtgacgtaatggcccccacCcagaattcctgaatggcact	11	8	9	13	1	0	3	0	2	0	1	1	3	1	3	4	2	0	2	4	2	3	2	rs17405746		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr17:58257980C>T	uc002iyo.1	-	33	4853	c.4567G>A	c.(4567-4569)GGT>AGT	p.G1523S	USP32_uc002iyn.1_Missense_Mutation_p.G1193S	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1523					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TGGCCCCCACCCAGAATTCCT	0.443													12	22					0	0	0	0	T	58257980	T	T	58257980	3	4	91	1	0	0	0	0	1	0	0	0	17131	623	22	4	255	4	USP32	17	58257980	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	12594978	58257980	22937230	61	17832											
NEDD4L	23327	broad.mit.edu	37	chr18	55711935	55711935	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggtctatggactttccgaaGacgaggtgagtggcaccccc	8	8	13	12	3	1	2	0	1	1	1	2	5	2	3	3	4	0	1	3	4	2	2	rs12968145		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr18:55711935G>A	uc002lgy.2	+	1	317	c.43G>A	c.(43-45)GAC>AAC	p.D15N	NEDD4L_uc002lgz.2_Missense_Mutation_p.D15N|NEDD4L_uc002lgx.2_Missense_Mutation_p.D15N|NEDD4L_uc010xee.1_5'Flank|NEDD4L_uc002lha.1_5'Flank	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	15	C2.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						ACTTTCCGAAGACGAGGTGAG	0.741													5	23					0	0	0	0	A	55711935	A	A	55711935	3	1	91	1	0	0	0	0	1	0	0	0	10365	942	33	2	45	2	NEDD4L	18	55711935	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		55711935	22365313	62	17833											
ZNF461	92283	broad.mit.edu	37	chr19	37130912	37130912	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cataaatatccctttttggaGataacttctggggctcatct	10	15	7	9	0	3	1	1	0	2	1	4	2	4	1	1	3	1	1	1	3	4	6			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:37130912G>T	uc002oem.2	-	6	563	c.335C>A	c.(334-336)TCT>TAT	p.S112Y	ZNF461_uc002oen.2_Missense_Mutation_p.S81Y|ZNF461_uc010xtj.1_Missense_Mutation_p.S89Y	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CCTTTTTGGAGATAACTTCTG	0.348													12	85					2.27111e-07	2.32273e-07	1	0	T	37130912	T	T	37130912	3	4	91	1	0	0	0	0	1	0	0	0	17992	942	33	2	1360	2	ZNF461	19	37130912	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		37130912	21998071	63	17834											
SNRPA	6626	broad.mit.edu	37	chr19	41268965	41268965	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcttatgccaggacagatgCcccctgcccagcctgtgagt	8	8	11	14	0	0	2	0	1	0	1	0	3	0	3	5	1	5	1	5	1	1	1			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:41268965C>T	uc002ooz.2	+	4	1121	c.586C>T	c.(586-588)CCC>TCC	p.P196S	SNRPA_uc002opa.2_Missense_Mutation_p.P146S	NM_004596	NP_004587	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A	196	Pro-rich.					nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			skin(2)|ovary(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			AGGACAGATGCCCCCTGCCCA	0.607													12	42					0	0	0	0	T	41268965	T	T	41268965	3	4	91	1	0	0	0	0	1	0	0	0	14923	739	26	4	600	4	SNRPA	19	41268965	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	4138053	41268965	17860018	64	17835											
GRIK5	2901	broad.mit.edu	37	chr19	42563637	42563637	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcactgacagcgtctccttgGagatgaggaagccacgcacc	10	7	11	13	2	2	3	1	2	1	1	3	5	2	4	3	2	2	1	3	2	1	1			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:42563637G>C	uc002osj.1	-	5	586	c.551C>G	c.(550-552)TCC>TGC	p.S184C	GRIK5_uc010eib.1_Missense_Mutation_p.S103C	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	184	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CGTCTCCTTGGAGATGAGGAA	0.607													13	68					0	0	0	0	C	42563637	C	C	42563637	3	2	91	1	0	0	0	0	1	0	0	0	6816	1174	41	2	2451	2	GRIK5	19	42563637	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	1294672	42563637	16565346	65	17836											
MARK4	57787	broad.mit.edu	37	chr19	45774927	45774927	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggagtcatcctgtacaccctCgtcagcggctccctgccctt	5	10	9	17	2	2	0	2	0	0	0	5	1	4	1	4	2	3	2	4	2	1	2	rs140158030		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:45774927C>T	uc002pbb.1	+	8	752	c.747C>T	c.(745-747)CTC>CTT	p.L249L	MARK4_uc002paz.1_Missense_Mutation_p.S60L|MARK4_uc002pba.1_Silent_p.L249L|MARK4_uc002pbc.1_Silent_p.L115L			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	249	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGTACACCCTCGTCAGCGGCT	0.672													68	42					0	0	0	0	T	45774927	T	T	45774927	2	4	91	1	0	0	0	0	0	0	0	1	9368	871	31	1		1	MARK4	19	45774927	Silent	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	3211290	45774927	13354056	66	17837											
ZNF347	84671	broad.mit.edu	37	chr19	53643919	53643919	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgggtagttaggcttgaaCggacactaaaggctttccca	11	10	12	8	1	0	1	0	1	0	0	1	3	1	2	1	4	1	4	1	4	5	5	rs150489253	byFrequency	TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:53643919C>A	uc002qbb.1	-	5	2231	c.2162G>T	c.(2161-2163)CGT>CTT	p.R721L	ZNF347_uc010eql.1_Missense_Mutation_p.R722L|ZNF347_uc002qbc.1_Missense_Mutation_p.R722L	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	721	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TAGGCTTGAACGGACACTAAA	0.423													41	168					4.16155e-14	4.51252e-14	1	0	A	53643919	A	A	53643919	3	1	91	1	0	0	0	0	1	0	0	0	17928	536	19	3	361	3	ZNF347	19	53643919	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	7868992	53643919	5485064	67	17838											
EPN1	29924	broad.mit.edu	37	chr19	56203254	56203254	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcggacccctggggcggcccCcctgtccctccagctgctga	3	7	12	19	2	0	1	0	1	0	0	3	2	2	2	7	4	2	2	7	4	0	0			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:56203254C>T	uc002qlw.2	+	7	1239	c.897C>T	c.(895-897)CCC>CCT	p.P299P	EPN1_uc002qlv.2_Silent_p.P274P|EPN1_uc010etd.2_Silent_p.P299P|EPN1_uc002qlx.2_Silent_p.P385P	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	299	Ala/Gly/Pro-rich.|8 X 3 AA repeats of [ED]-P-W.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		GGGGCGGCCCCCCTGTCCCTC	0.756													9	29					0	0	0	0	T	56203254	T	T	56203254	2	4	91	1	0	0	0	0	0	0	0	1	5209	610	22	4		4	EPN1	19	56203254	Silent	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	2559335	56203254	2925729	68	17839											
AURKC	6795	broad.mit.edu	37	chr19	57743501	57743501	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaggaaagccatttcattGtggccctgaaggttctcttc	9	13	9	10	0	3	1	2	1	1	0	5	2	3	2	2	3	1	1	2	3	3	4			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr19:57743501G>A	uc002qoe.2	+	3	394	c.205G>A	c.(205-207)GTG>ATG	p.V69M	AURKC_uc002qoc.2_Missense_Mutation_p.V50M|AURKC_uc002qod.2_Missense_Mutation_p.V35M|AURKC_uc010etv.2_Missense_Mutation_p.V66M	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	69	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		CCATTTCATTGTGGCCCTGAA	0.542													34	30					0	0	0	0	A	57743501	A	A	57743501	3	1	91	1	0	0	0	0	1	0	0	0	1226	1377	48	4	220	4	AURKC	19	57743501	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	1540247	57743501	1385482	69	17840											
SIGLEC1	6614	broad.mit.edu	37	chr20	3684688	3684688	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaccagctcacctggaaGgatgttcctccccgaggggc	7	8	13	13	1	1	1	1	1	0	0	3	4	3	3	5	4	1	2	5	4	1	1			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr20:3684688G>A	uc002wja.2	-	4	757	c.757C>T	c.(757-759)CTT>TTT	p.L253F	SIGLEC1_uc002wiz.3_Missense_Mutation_p.L253F|SIGLEC1_uc002wjc.2_Missense_Mutation_p.L164F	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	253	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						TCACCTGGAAGGATGTTCCTC	0.577													18	38					0	0	0	0	A	3684688	A	A	3684688	3	1	91	1	0	0	0	0	1	0	0	0	14370	1000	35	4	4444	4	SIGLEC1	20	3684688	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		3684688	59340832	70	17841											
CDS2	8760	broad.mit.edu	37	chr20	5169814	5169814	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcttcgcaagtggattcaaAcgagcctttaaaatcaaagt	14	12	7	8	2	3	0	2	0	1	0	4	2	3	1	1	1	2	1	1	1	5	5			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr20:5169814A>C	uc002wls.2	+	11	1340	c.1083A>C	c.(1081-1083)AAA>AAC	p.K361N	CDS2_uc010zqt.1_RNA|CDS2_uc002wlu.2_Missense_Mutation_p.N313T|CDS2_uc010zqu.1_Missense_Mutation_p.K241N|CDS2_uc002wlv.2_Missense_Mutation_p.K263N|CDS2_uc010zqv.1_Missense_Mutation_p.K131N	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2	361					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0						GTGGATTCAAACGAGCCTTTA	0.517													23	41					0	0	0	0	C	5169814	C	C	5169814	3	2	91	1	0	0	0	0	1	0	0	0	3193	40	2	5	1125	5	CDS2	20	5169814	Missense_Mutation	SNP	A	TCGA-CQ-5324-01A-01D-1683-08	1485126	5169814	57855706	71	17842											
PYGB	5834	broad.mit.edu	37	chr20	25239873	25239873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctttcttctgcttcctcagCgcatttattatctttccctg	4	20	4	13	1	5	0	1	0	4	0	7	0	7	0	2	0	2	2	2	0	2	7			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr20:25239873C>T	uc002wup.2	+	2	353	c.244C>T	c.(244-246)CGC>TGC	p.R82C		NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	82					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	GCTTCCTCAGCGCATTTATTA	0.478													10	27					0	0	0	0	T	25239873	T	T	25239873	3	4	91	1	0	0	0	0	1	0	0	0	12925	782	27	1	250	1	PYGB	20	25239873	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	20070059	25239873	37785647	72	17843											
DNTTIP1	116092	broad.mit.edu	37	chr20	44439538	44439538	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcaggcctacctcctcatCgaggaggacatccgggacct	8	7	10	16	2	2	0	2	0	0	0	5	4	4	3	6	4	1	0	6	4	1	1	rs148278422		TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr20:44439538C>T	uc002xpk.2	+	12	878	c.810C>T	c.(808-810)ATC>ATT	p.I270I	UBE2C_uc002xpl.2_5'Flank|UBE2C_uc002xpm.2_5'Flank|UBE2C_uc002xpn.2_5'Flank|UBE2C_uc002xpo.2_5'Flank|UBE2C_uc002xpp.2_5'Flank|UBE2C_uc002xpq.2_5'Flank	NM_052951	NP_443183	Q9H147	TDIF1_HUMAN	terminal deoxynucleotidyltransferase interacting	270						nucleus				ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.0122)				ACCTCCTCATCGAGGAGGACA	0.507													14	28					0	0	0	0	T	44439538	T	T	44439538	2	4	91	1	0	0	0	0	0	0	0	1	4703	874	31	1		1	DNTTIP1	20	44439538	Silent	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	19199665	44439538	18585982	73	17844											
TIAM1	7074	broad.mit.edu	37	chr21	32639127	32639127	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgctgctggatcgggtgctCacttcggagttcctgtggat	4	13	15	9	2	1	0	1	0	0	0	4	3	2	3	1	4	3	4	1	4	0	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr21:32639127C>G	uc002yow.1	-	5	634	c.162G>C	c.(160-162)GTG>GTC	p.V54V	TIAM1_uc011adk.1_Silent_p.V54V|TIAM1_uc011adl.1_Silent_p.V54V|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	54					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						ATCGGGTGCTCACTTCGGAGT	0.637													10	31					0	0	0	0	G	32639127	G	G	32639127	2	3	91	1	0	0	0	0	0	0	0	1	15956	813	29	2		2	TIAM1	21	32639127	Silent	SNP	C	TCGA-CQ-5324-01A-01D-1683-08		32639127	15490768	74	17845			1	22		2	2	22	C		5.426782e-05
TIAM1	7074	broad.mit.edu	37	chr21	32639148	32639148	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttcggagttcctgtggatCaccttccccgaggaagcgtg	7	10	12	12	3	1	0	1	0	0	0	4	4	3	3	4	3	1	1	4	3	1	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr21:32639148C>T	uc002yow.1	-	5	613	c.141G>A	c.(139-141)GTG>GTA	p.V47V	TIAM1_uc011adk.1_Silent_p.V47V|TIAM1_uc011adl.1_Silent_p.V47V|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	47					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TCCTGTGGATCACCTTCCCCG	0.627													7	30					0	0	0	0	T	32639148	T	T	32639148	2	4	91	1	0	0	0	0	0	0	0	1	15956	813	29	2		2	TIAM1	21	32639148	Silent	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	21	32639148	15490747	75	17846			1	22		2	2	22	C		5.426782e-05
TTC3	7267	broad.mit.edu	37	chr21	38538338	38538338	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgggcaacccaaaggggtCtcttctaattctcctaaacc	11	10	8	12	0	3	0	0	0	3	0	5	1	3	0	3	3	2	1	3	3	5	4			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr21:38538338C>G	uc002yvz.2	+	33	3927	c.3822C>G	c.(3820-3822)GTC>GTG	p.V1274V	TTC3_uc011aee.1_Silent_p.V964V|TTC3_uc002ywa.2_Silent_p.V1274V|TTC3_uc002ywb.2_Silent_p.V1274V|TTC3_uc010gnf.2_Silent_p.V1039V|TTC3_uc002ywc.2_Silent_p.V964V|TTC3_uc002ywd.1_Silent_p.V338V	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1274					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				CCAAAGGGGTCTCTTCTAATT	0.458													30	53					0	0	0	0	G	38538338	G	G	38538338	2	3	91	1	0	0	0	0	0	0	0	1	16765	900	32	2		2	TTC3	21	38538338	Silent	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	5899190	38538338	9591557	76	17847											
CCT8L2	150160	broad.mit.edu	37	chr22	17072531	17072531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atacttgtccgccagtgtgaGggtctcctcgtcgacctccc	5	11	10	15	3	1	1	0	1	1	0	6	2	3	1	5	1	1	0	5	1	1	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr22:17072531G>A	uc002zlp.1	-	1	1170	c.910C>T	c.(910-912)CTC>TTC	p.L304F		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	304					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GCCAGTGTGAGGGTCTCCTCG	0.512													53	81					0	0	0	0	A	17072531	A	A	17072531	3	1	91	1	0	0	0	0	1	0	0	0	2976	1000	35	4	767	4	CCT8L2	22	17072531	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		17072531	34232035	77	17848											
SEC14L4	284904	broad.mit.edu	37	chr22	30891410	30891410	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtagccacaaagaccacccGagtcatacagctggatgacc	13	5	9	14	2	1	2	1	1	0	1	1	4	1	3	4	1	3	2	4	1	3	2	rs145663781	byFrequency	TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr22:30891410G>A	uc003aid.2	-	5	354	c.254C>T	c.(253-255)TCG>TTG	p.S85L	SEC14L4_uc011akz.1_Missense_Mutation_p.S85L|SEC14L4_uc003aie.2_Missense_Mutation_p.S70L|SEC14L4_uc003aif.2_Missense_Mutation_p.S31L	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a	85	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	AAGACCACCCGAGTCATACAG	0.582													25	44					0	0	0	0	A	30891410	A	A	30891410	3	1	91	1	0	0	0	0	1	0	0	0	14049	1059	37	1	1004	1	SEC14L4	22	30891410	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	13818879	30891410	20413156	78	17849											
C22orf9	23313	broad.mit.edu	37	chr22	45607844	45607844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggggtcactcaccttcctcCcgtctgcaccgctttcgctg	3	11	10	17	3	3	0	2	0	1	0	6	0	5	0	4	2	1	3	4	2	0	2			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chr22:45607844C>T	uc003bfx.1	-	2	275	c.209G>A	c.(208-210)GGG>GAG	p.G70E	C22orf9_uc003bfv.1_Missense_Mutation_p.G79E|C22orf9_uc003bfw.1_Missense_Mutation_p.G75E|C22orf9_uc010gzx.2_Missense_Mutation_p.G52E	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	70							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		CACCTTCCTCCCGTCTGCACC	0.617													37	74					0	0	0	0	T	45607844	T	T	45607844	3	4	91	1	0	0	0	0	1	0	0	0	2161	623	22	4	1041	4	C22orf9	22	45607844	Missense_Mutation	SNP	C	TCGA-CQ-5324-01A-01D-1683-08	14716434	45607844	5696722	79	17850											
FAM47B	170062	broad.mit.edu	37	chrX	34962352	34962352	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaactccgtgacttcaagtgGgctggagacctaggagttaa	12	9	12	8	1	1	2	1	1	0	1	2	4	2	3	2	3	1	2	2	3	4	3			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chrX:34962352G>A	uc004ddi.1	+	1	1422	c.1404G>A	c.(1402-1404)TGG>TGA	p.W468*		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	468										ovary(3)|breast(1)	4						ACTTCAAGTGGGCTGGAGACC	0.433													4	45					0	0	0	0	A	34962352	A	A	34962352	4	1	91	1	0	0	0	0	0	1	0	0	5602	1241	43	4	1406	4	FAM47B	23	34962352	Nonsense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08		34962352	120308208	80	17851											
ELF4	2000	broad.mit.edu	37	chrX	129201147	129201147	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacagtcccagggggctgaGagctgggccctgctggtcca	6	7	16	12	0	0	2	0	2	0	1	2	3	2	2	3	4	2	3	3	4	0	0			TCGA-CQ-5324-01A-01D-1683-08	TCGA-CQ-5324-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	67b184fe-c4f4-49f3-938e-5370eb6246b9	a635afcc-e437-4cc7-80ff-b710698cfde3	g.chrX:129201147G>A	uc004evd.3	-	9	1926	c.1541C>T	c.(1540-1542)TCT>TTT	p.S514F	ELF4_uc004eve.3_Missense_Mutation_p.S514F	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	514					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGGGGGCTGAGAGCTGGGCCC	0.642			T	ERG	AML								24	10					0	0	0	0	A	129201147	A	A	129201147	3	1	91	1	0	0	0	0	1	0	0	0	5080	942	33	2	454	2	ELF4	23	129201147	Missense_Mutation	SNP	G	TCGA-CQ-5324-01A-01D-1683-08	94238795	129201147	26069413	81	17852											
FCN3	8547	broad.mit.edu	37	chr1	27697413	27697413	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaacctgctctgtaggaGgaccaagagcggaagaaatc	15	5	11	10	1	1	2	0	0	1	2	2	5	1	5	3	3	3	2	3	3	6	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr1:27697413G>A	uc001boa.2	-	6	450	c.444C>T	c.(442-444)TCC>TCT	p.S148S	FCN3_uc001bob.2_Silent_p.S137S	NM_003665	NP_003656	O75636	FCN3_HUMAN	ficolin 3 isoform 1 precursor	148	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding				0		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CTCTGTAGGAGGACCAAGAGC	0.562													11	64					0	0	0	0	A	27697413	A	A	27697413	2	1	92	1	0	0	0	0	0	0	0	1	5825	987	35	4		4	FCN3	1	27697413	Silent	SNP	G	TCGA-CQ-5325-01A-01D-1683-08		27697413	221553208	1	17853											
C1orf94	84970	broad.mit.edu	37	chr1	34666421	34666421	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagggtcaagggagcctctTtctcagccagtggccccaga	10	7	12	12	0	3	1	2	0	2	1	4	2	3	2	4	3	2	0	4	3	2	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr1:34666421T>C	uc001bxs.3	+	3	887	c.488T>C	c.(487-489)TTT>TCT	p.F163S	C1orf94_uc001bxt.2_Missense_Mutation_p.F353S	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	163							protein binding				0		Myeloproliferative disorder(586;0.0393)				GGGAGCCTCTTTCTCAGCCAG	0.582													7	61					0	0	0	0	C	34666421	C	C	34666421	3	2	92	1	0	0	0	0	1	0	0	0	2081	1841	64	5	1068	5	C1orf94	1	34666421	Missense_Mutation	SNP	T	TCGA-CQ-5325-01A-01D-1683-08	6969008	34666421	214584200	2	17854											
SLC26A9	115019	broad.mit.edu	37	chr1	205904863	205904863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctcccactgggtatgtcCggtccttcttctcaaactca	6	14	6	15	1	4	0	2	0	3	0	9	0	7	0	3	2	1	1	3	2	2	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr1:205904863C>T	uc001hdq.2	-	2	200	c.86G>A	c.(85-87)CGG>CAG	p.R29Q	SLC26A9_uc001hdp.2_Missense_Mutation_p.R29Q	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	29						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TGGGTATGTCCGGTCCTTCTT	0.547													14	90					0	0	0	0	T	205904863	T	T	205904863	3	4	92	1	0	0	0	0	1	0	0	0	14588	652	23	1	2665	1	SLC26A9	1	205904863	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	171238442	205904863	43345758	3	17855											
GALNT13	114805	broad.mit.edu	37	chr2	155158099	155158099	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atttcttctacatcatatccCcaggtacacaattctgacat	12	14	3	12	0	4	1	1	1	3	0	5	1	5	1	2	1	2	1	2	1	4	6			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr2:155158099C>T	uc002tyr.3	+	9	1720	c.1153C>T	c.(1153-1155)CCA>TCA	p.P385S	GALNT13_uc002tyt.3_Missense_Mutation_p.P385S|GALNT13_uc010foc.1_Missense_Mutation_p.P204S|GALNT13_uc010fod.2_Missense_Mutation_p.P138S	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	385	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CATCATATCCCCAGGTACACA	0.348													6	99					0	0	0	0	T	155158099	T	T	155158099	3	4	92	1	0	0	0	0	1	0	0	0	6246	623	22	4	1179	4	GALNT13	2	155158099	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08		155158099	88041274	4	17856											
XIRP2	129446	broad.mit.edu	37	chr2	167760367	167760367	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgtgtttgaggctcctaaGagtggaaacaaaccagctga	13	9	12	7	0	0	3	0	2	0	1	1	4	1	4	2	2	3	3	2	2	3	2			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr2:167760367G>C	uc002udx.2	+	1	393	c.375G>C	c.(373-375)AAG>AAC	p.K125N	XIRP2_uc010fpn.2_Missense_Mutation_p.K125N|XIRP2_uc010fpo.2_Missense_Mutation_p.K125N|XIRP2_uc010fpp.2_Missense_Mutation_p.K125N	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGGCTCCTAAGAGTGGAAACA	0.483													6	51					0	0	0	0	C	167760367	C	C	167760367	3	2	92	1	0	0	0	0	1	0	0	0	17498	933	33	2	377	2	XIRP2	2	167760367	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	12602268	167760367	75439006	5	17857											
TTN	7273	broad.mit.edu	37	chr2	179404673	179404673	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accttcttggtatctttcatCaagttcataatcaggatatt	11	17	5	8	0	6	0	4	0	2	0	6	1	6	1	1	2	0	2	1	2	4	8			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr2:179404673C>G	uc010zfg.1	-	301	90639	c.90415G>C	c.(90415-90417)GAT>CAT	p.D30139H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D23834H|TTN_uc010zfi.1_Missense_Mutation_p.D23767H|TTN_uc010zfj.1_Missense_Mutation_p.D23642H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31066							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTTTCATCAAGTTCATAA	0.373													4	70					0	0	0	0	G	179404673	G	G	179404673	3	3	92	1	0	0	0	0	1	0	0	0	16803	826	29	2	9904	2	TTN	2	179404673	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	11644306	179404673	63794700	6	17858											
VIL1	7429	broad.mit.edu	37	chr2	219299377	219299377	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaatttcctcaattccaaTgatgtctttgtcctcaagac	10	14	5	12	0	3	2	2	1	1	1	6	2	6	2	4	0	0	0	4	0	4	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr2:219299377T>G	uc002via.2	+	14	1694	c.1629T>G	c.(1627-1629)AAT>AAG	p.N543K	VIL1_uc010zke.1_Missense_Mutation_p.N232K|VIL1_uc002vib.2_Missense_Mutation_p.N543K	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	543	Gelsolin-like 5.|Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAATTCCAATGATGTCTTTG	0.582													14	94					0	0	0	0	G	219299377	G	G	219299377	3	3	92	1	0	0	0	0	1	0	0	0	17232	1461	51	5	1679	5	VIL1	2	219299377	Missense_Mutation	SNP	T	TCGA-CQ-5325-01A-01D-1683-08	39894704	219299377	23899996	7	17859											
GIGYF2	26058	broad.mit.edu	37	chr2	233671317	233671317	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcttggcgatatcatgaaaAtgtggggaagggttcccttt	9	13	12	7	1	2	1	1	1	1	0	3	3	3	2	1	4	0	1	1	4	4	4			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr2:233671317A>T	uc002vti.3	+	17	2093	c.1756A>T	c.(1756-1758)ATG>TTG	p.M586L	GIGYF2_uc010zmj.1_Missense_Mutation_p.M586L|GIGYF2_uc002vtg.2_Missense_Mutation_p.M580L|GIGYF2_uc002vtj.3_Missense_Mutation_p.M607L|GIGYF2_uc002vtk.3_Missense_Mutation_p.M586L|GIGYF2_uc002vth.3_Missense_Mutation_p.M580L|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.M417L	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	586					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TATCATGAAAATGTGGGGAAG	0.463													10	106					0	0	0	0	T	233671317	T	T	233671317	3	4	92	1	0	0	0	0	1	0	0	0	6415	101	4	5	1876	5	GIGYF2	2	233671317	Missense_Mutation	SNP	A	TCGA-CQ-5325-01A-01D-1683-08	14371940	233671317	9528056	8	17860											
SLC2A9	56606	broad.mit.edu	37	chr4	9998412	9998412	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcctactgacctcccaaGaacctttccaatcatcttca	10	11	3	17	0	3	2	2	1	1	1	6	2	6	2	6	0	2	0	6	0	4	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr4:9998412G>T	uc003gmc.2	-	3	464	c.403C>A	c.(403-405)CTT>ATT	p.L135I	SLC2A9_uc003gmd.2_Missense_Mutation_p.L106I	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	135	Cytoplasmic (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						GACCTCCCAAGAACCTTTCCA	0.498													6	23					3.59834e-05	4.0981e-05	1	0	T	9998412	T	T	9998412	3	4	92	1	0	0	0	0	1	0	0	0	14616	942	33	2	1259	2	SLC2A9	4	9998412	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08		9998412	181155864	9	17861											
CLOCK	9575	broad.mit.edu	37	chr4	56316289	56316289	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagacggccgtgtgagatgaTtttcttgaactccgagaaga	11	10	13	7	3	1	6	0	3	1	4	2	9	2	6	2	1	1	0	2	1	2	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr4:56316289T>C	uc003haz.1	-	17	2243	c.1317A>G	c.(1315-1317)AAA>AAG	p.K439K	CLOCK_uc003hba.1_Silent_p.K439K|CLOCK_uc010igu.1_5'Flank	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	439					circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			TGTGAGATGATTTTCTTGAAC	0.433													5	46					0	0	0	0	C	56316289	C	C	56316289	2	2	92	1	0	0	0	0	0	0	0	1	3564	1490	52	5		5	CLOCK	4	56316289	Silent	SNP	T	TCGA-CQ-5325-01A-01D-1683-08	46317877	56316289	134837987	10	17862											
AGXT2L1	64850	broad.mit.edu	37	chr4	109667916	109667916	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtgggtgtgggggtgaattActtgtagatgatgtgctgag	7	13	19	2	0	0	4	0	3	0	1	0	4	0	4	0	4	2	2	0	4	3	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr4:109667916A>C	uc003hzc.2	-	10	1353	c.1172_splice	c.e10+1	p.K391_splice	AGXT2L1_uc010imc.2_Splice_Site_p.K385_splice|AGXT2L1_uc011cfm.1_Splice_Site_p.K351_splice|AGXT2L1_uc011cfn.1_Splice_Site_p.K318_splice|AGXT2L1_uc011cfo.1_Splice_Site_p.K333_splice	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1						cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		GGGGTGAATTACTTGTAGATG	0.488													19	223					0	0	0	0	C	109667916	C	C	109667916	5	2	92	1	0	0	0	0	0	0	1	0	406	405	14	5	341	5	AGXT2L1	4	109667916	Splice_Site	SNP	A	TCGA-CQ-5325-01A-01D-1683-08	53351627	109667916	81486360	11	17863											
C5orf22	55322	broad.mit.edu	37	chr5	31541084	31541084	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaaatcttacaagagctgtAccaatttaagaaacctggca	17	9	6	9	0	1	2	0	0	1	2	1	2	1	2	2	1	4	3	2	1	8	4			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr5:31541084A>G	uc003jhj.3	+	5	963	c.836A>G	c.(835-837)TAC>TGC	p.Y279C	C5orf22_uc011cnw.1_Intron|C5orf22_uc003jhk.3_Missense_Mutation_p.Y14C	NM_018356	NP_060826	Q49AR2	CE022_HUMAN	hypothetical protein LOC55322	279										ovary(2)	2						CAAGAGCTGTACCAATTTAAG	0.294													7	66					0	0	0	0	G	31541084	G	G	31541084	3	3	92	1	0	0	0	0	1	0	0	0	2295	391	14	5	854	5	C5orf22	5	31541084	Missense_Mutation	SNP	A	TCGA-CQ-5325-01A-01D-1683-08		31541084	149374176	12	17864											
PCDHA7	56141	broad.mit.edu	37	chr5	140215046	140215046	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttccctgtctctccctattCcagaggacgcccaaccaggt	7	10	7	17	1	1	1	0	0	1	1	5	2	4	2	5	2	1	0	5	2	2	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr5:140215046C>A	uc003lhq.2	+	1	1078	c.1078C>A	c.(1078-1080)CCA>ACA	p.P360T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.P360T	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	360	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTCCCTATTCCAGAGGACGC	0.522													11	96					2.80697e-09	3.38488e-09	1	0	A	140215046	A	A	140215046	3	1	92	1	0	0	0	0	1	0	0	0	11583	855	30	2	1080	2	PCDHA7	5	140215046	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	108673962	140215046	40700214	13	17865											
PCDHGA9	56107	broad.mit.edu	37	chr5	140784899	140784899	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgagcctttgtgcgtcTctgttgattccaagtttcct	8	16	8	9	1	1	2	0	2	1	0	4	2	3	2	3	0	2	2	3	0	3	4			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr5:140784899T>C	uc003lkh.1	+	1	2380	c.2380T>C	c.(2380-2382)TCT>CCT	p.S794P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.S794P|PCDHGB6_uc003lki.1_5'Flank|PCDHGB6_uc003lkj.1_5'Flank	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	794	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTGTGCGTCTCTGTTGATTC	0.403													4	35					0	0	0	0	C	140784899	C	C	140784899	3	2	92	1	0	0	0	0	1	0	0	0	11615	1551	54	5	2382	5	PCDHGA9	5	140784899	Missense_Mutation	SNP	T	TCGA-CQ-5325-01A-01D-1683-08	569853	140784899	40130361	14	17866											
CD2AP	23607	broad.mit.edu	37	chr6	47563699	47563699	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccagtaatttactgagatCttctggaacagtgtacccaa	13	11	8	9	0	2	1	0	1	2	1	2	3	2	2	2	1	4	2	2	1	5	5			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr6:47563699C>T	uc003oyw.2	+	12	1667	c.1211C>T	c.(1210-1212)TCT>TTT	p.S404F		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	404	Pro-rich.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			TTACTGAGATCTTCTGGAACA	0.418													19	156					0	0	0	0	T	47563699	T	T	47563699	3	4	92	1	0	0	0	0	1	0	0	0	3009	913	32	2	1257	2	CD2AP	6	47563699	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08		47563699	123551368	15	17867											
AKAP12	9590	broad.mit.edu	37	chr6	151671792	151671792	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccctaccgaaggggagggcGtttccacctgggagtcattt	7	9	14	11	2	1	0	1	0	0	0	2	3	2	2	4	4	1	1	4	4	2	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr6:151671792G>A	uc011eep.1	+	4	2506	c.2266G>A	c.(2266-2268)GTT>ATT	p.V756I	AKAP12_uc003qoe.2_Missense_Mutation_p.V756I|AKAP12_uc003qof.2_Missense_Mutation_p.V658I|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.V651I	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	756	AKAP 2.				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		AGGGGAGGGCGTTTCCACCTG	0.537													13	174					0	0	0	0	A	151671792	A	A	151671792	3	1	92	1	0	0	0	0	1	0	0	0	448	1145	40	1	2305	1	AKAP12	6	151671792	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	104108093	151671792	19443275	16	17868											
DOCK4	9732	broad.mit.edu	37	chr7	111368576	111368576	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctcctccccgccgtagctCggcacgggcaccggcactgg	4	5	14	18	5	0	0	0	0	0	0	3	0	2	0	5	5	1	6	5	5	1	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr7:111368576C>T	uc003vfx.2	-	52	5924	c.5655G>A	c.(5653-5655)CCG>CCA	p.P1885P	DOCK4_uc011kml.1_Silent_p.P766P|DOCK4_uc011kmm.1_Silent_p.P754P|DOCK4_uc003vfw.2_Silent_p.P1297P|DOCK4_uc003vfy.2_Silent_p.P1930P|DOCK4_uc003vfv.2_Silent_p.P198P	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1885	Pro-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CGCCGTAGCTCGGCACGGGCA	0.662													6	51					0	0	0	0	T	111368576	T	T	111368576	2	4	92	1	0	0	0	0	0	0	0	1	4711	871	31	1		1	DOCK4	7	111368576	Silent	SNP	C	TCGA-CQ-5325-01A-01D-1683-08		111368576	47770087	17	17869											
CPA5	93979	broad.mit.edu	37	chr7	129986247	129986247	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcaggctgggctttccaGcctctaggtgctgtgctgtc	3	14	12	12	0	2	0	1	0	2	0	5	0	3	0	2	3	3	4	2	3	1	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr7:129986247G>A	uc010lmd.1	+	4	542	c.-78_splice	c.e4-1		CPA5_uc003vps.2_5'UTR|CPA5_uc003vpt.2_5'UTR|CPA5_uc010lme.1_5'UTR|CPA5_uc003vpu.1_Splice_Site	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1						proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)					GGGCTTTCCAGCCTCTAGGTG	0.637													4	28					0	0	0	0	A	129986247	A	A	129986247	5	1	92	1	0	0	0	0	0	0	1	0	3808	985	34	4		4	CPA5	7	129986247	Splice_Site	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	18617671	129986247	29152416	18	17870											
XRCC2	7516	broad.mit.edu	37	chr7	152346254	152346254	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcagtatttgattatttCttcagagctttgggatagtc	9	16	10	6	0	2	2	1	1	1	1	3	3	2	3	0	2	1	3	0	2	3	7			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr7:152346254C>A	uc003wld.2	-	3	402	c.316G>T	c.(316-318)GAA>TAA	p.E106*		NM_005431	NP_005422	O43543	XRCC2_HUMAN	X-ray repair cross complementing protein 2	106					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			breast(1)|liver(1)	2		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		TTGATTATTTCTTCAGAGCTT	0.378								Homologous_recombination					10	78					3.86212e-05	4.33827e-05	1	0	A	152346254	A	A	152346254	4	1	92	1	0	0	0	0	0	1	0	0	17521	922	32	2	530	2	XRCC2	7	152346254	Nonsense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	22360007	152346254	6792409	19	17871											
EPHX2	2053	broad.mit.edu	37	chr8	27373874	27373874	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcaggttaccgggtcctagCtatggacatgaaaggctatg	10	9	14	8	1	0	1	0	1	0	0	1	2	1	2	2	5	2	4	2	5	5	4			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr8:27373874C>A	uc003xfu.2	+	8	950	c.869C>A	c.(868-870)GCT>GAT	p.A290D	EPHX2_uc010lut.1_Missense_Mutation_p.A290D|EPHX2_uc010luu.2_Missense_Mutation_p.A258D|EPHX2_uc010luv.2_Missense_Mutation_p.A224D|EPHX2_uc003xfv.2_Missense_Mutation_p.A237D|EPHX2_uc010luw.2_Missense_Mutation_p.A224D|EPHX2_uc011lam.1_Missense_Mutation_p.A146D	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	290	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	CGGGTCCTAGCTATGGACATG	0.557											OREG0018668	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	193					1.96895e-08	2.33991e-08	1	0	A	27373874	A	A	27373874	3	1	92	1	0	0	0	0	1	0	0	0	5204	797	28	4	899	4	EPHX2	8	27373874	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08		27373874	118990148	20	17872											
FUT10	84750	broad.mit.edu	37	chr8	33310867	33310867	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaccaccagagcataatgggGtagctgtccaattcccattt	11	10	9	11	0	0	1	0	0	0	1	2	2	2	1	4	2	2	3	4	2	3	4			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr8:33310867G>A	uc003xje.2	-	3	599	c.243C>T	c.(241-243)TAC>TAT	p.Y81Y	FUT10_uc003xjc.2_Silent_p.Y88Y|FUT10_uc003xjd.2_Silent_p.Y53Y|FUT10_uc011lbi.1_Silent_p.Y131Y|FUT10_uc003xjf.2_Missense_Mutation_p.P7S|FUT10_uc003xjg.2_Silent_p.Y53Y|FUT10_uc003xjh.2_Silent_p.Y81Y|FUT10_uc003xji.1_Silent_p.Y81Y	NM_032664	NP_116053	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10	81	Lumenal (Potential).				embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			ovary(1)|pancreas(1)	2				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		GCATAATGGGGTAGCTGTCCA	0.478													3	33					0	0	0	0	A	33310867	A	A	33310867	2	1	92	1	0	0	0	0	0	0	0	1	6136	1256	44	4		4	FUT10	8	33310867	Silent	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	5936993	33310867	113053155	21	17873											
ADAM2	2515	broad.mit.edu	37	chr8	39678606	39678606	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catctgctttcttatgttttActtggtaaattacatgttca	9	20	5	7	0	3	0	1	0	2	0	3	0	3	0	0	1	3	4	0	1	5	8			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr8:39678606A>C	uc003xnj.2	-	6	503	c.428T>G	c.(427-429)GTA>GGA	p.V143G	ADAM2_uc003xnk.2_Missense_Mutation_p.V143G|ADAM2_uc011lck.1_Missense_Mutation_p.V143G|ADAM2_uc003xnl.2_Missense_Mutation_p.V143G	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	143					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTTATGTTTTACTTGGTAAAT	0.328													8	42					0	0	0	0	C	39678606	C	C	39678606	3	2	92	1	0	0	0	0	1	0	0	0	241	391	14	5	1839	5	ADAM2	8	39678606	Missense_Mutation	SNP	A	TCGA-CQ-5325-01A-01D-1683-08	6367739	39678606	106685416	22	17874											
RGS20	8601	broad.mit.edu	37	chr8	54764582	54764582	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatacagacattcaccaaatCacagaaaatgaaggagacct	20	6	6	9	0	2	4	2	1	0	3	2	5	2	4	2	1	1	0	2	1	6	2			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr8:54764582C>T	uc003xrp.2	+	1	215	c.123C>T	c.(121-123)ATC>ATT	p.I41I	RGS20_uc003xrq.2_Silent_p.I41I|RGS20_uc010lye.2_5'UTR|RGS20_uc010lyf.2_5'UTR	NM_170587	NP_733466	O76081	RGS20_HUMAN	regulator of G-protein signaling 20 isoform a	41					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			TTCACCAAATCACAGAAAATG	0.458													13	79					0	0	0	0	T	54764582	T	T	54764582	2	4	92	1	0	0	0	0	0	0	0	1	13368	816	29	2		2	RGS20	8	54764582	Silent	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	15085976	54764582	91599440	23	17875											
SULF1	23213	broad.mit.edu	37	chr8	70488393	70488393	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccccctcgtggcaggccatgCatgagcctcggacttttgct	5	10	11	15	2	0	1	0	1	0	0	2	2	0	2	4	3	3	3	4	3	0	2			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr8:70488393C>T	uc010lza.1	+	6	1078	c.361C>T	c.(361-363)CAT>TAT	p.H121Y	SULF1_uc003xyd.2_Missense_Mutation_p.H121Y|SULF1_uc003xye.2_Missense_Mutation_p.H121Y|SULF1_uc003xyf.2_Missense_Mutation_p.H121Y|SULF1_uc003xyg.2_Missense_Mutation_p.H121Y	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	121					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GCAGGCCATGCATGAGCCTCG	0.498													11	55					0	0	0	0	T	70488393	T	T	70488393	3	4	92	1	0	0	0	0	1	0	0	0	15436	710	25	4	367	4	SULF1	8	70488393	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	15723811	70488393	75875629	24	17876											
ZFHX4	79776	broad.mit.edu	37	chr8	77765833	77765833	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatctgatgcatcattcagtAaaaggtcttctagaacgaga	15	11	8	7	1	5	3	2	1	3	2	5	4	5	3	0	1	2	2	0	1	5	4			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr8:77765833A>G	uc003yav.2	+	10	6928	c.6541A>G	c.(6541-6543)AAA>GAA	p.K2181E	ZFHX4_uc003yau.1_Missense_Mutation_p.K2226E|ZFHX4_uc003yaw.1_Missense_Mutation_p.K2181E	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2181	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATCATTCAGTAAAAGGTCTTC	0.373										HNSCC(33;0.089)			7	51					0	0	0	0	G	77765833	G	G	77765833	3	3	92	1	0	0	0	0	1	0	0	0	17702	363	13	5	6710	5	ZFHX4	8	77765833	Missense_Mutation	SNP	A	TCGA-CQ-5325-01A-01D-1683-08	7277440	77765833	68598189	25	17877											
RRM2B	50484	broad.mit.edu	37	chr8	103237159	103237159	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctatcagcaaactgtacaTctctgagtgaacattctcga	12	12	7	10	1	4	2	1	2	3	0	6	3	4	2	0	0	4	2	0	0	4	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr8:103237159T>A	uc003ykn.2	-	4	653	c.409A>T	c.(409-411)ATG>TTG	p.M137L	RRM2B_uc003yko.2_RNA|RRM2B_uc010mbv.1_Missense_Mutation_p.M85L|RRM2B_uc010mbw.1_Intron|RRM2B_uc010mbx.1_Intron|RRM2B_uc010mby.1_Intron	NM_015713	NP_056528	Q7LG56	RIR2B_HUMAN	ribonucleotide reductase M2 B (TP53 inducible)	137					deoxyribonucleoside diphosphate metabolic process|DNA repair|nucleobase, nucleoside and nucleotide interconversion	nucleoplasm	ribonucleoside-diphosphate reductase activity|transition metal ion binding			ovary(2)	2	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000728)			AAACTGTACATCTCTGAGTGA	0.408								Direct_reversal_of_damage|Modulation_of_nucleotide_pools					8	38					0	0	0	0	A	103237159	A	A	103237159	3	1	92	1	0	0	0	0	1	0	0	0	13748	1435	50	5	670	5	RRM2B	8	103237159	Missense_Mutation	SNP	T	TCGA-CQ-5325-01A-01D-1683-08	25471326	103237159	43126863	26	17878											
TPD52L3	89882	broad.mit.edu	37	chr9	6328607	6328607	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagtccatgccacatgcCaggacagagacctctgtggg	9	7	11	14	0	1	1	0	0	1	1	3	3	3	2	5	2	2	0	5	2	0	0			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr9:6328607C>G	uc003zjw.2	+	1	233	c.12C>G	c.(10-12)GCC>GCG	p.A4A	TPD52L3_uc003zjv.2_Silent_p.A4A|TPD52L3_uc003zjx.1_Silent_p.A4A	NM_033516	NP_277051	Q96J77	TPD55_HUMAN	protein kinase NYD-SP25 isoform 1	4							protein binding				0		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		TGCCACATGCCAGGACAGAGA	0.468													60	94					0	0	0	0	G	6328607	G	G	6328607	2	3	92	1	0	0	0	0	0	0	0	1	16467	581	21	4		4	TPD52L3	9	6328607	Silent	SNP	C	TCGA-CQ-5325-01A-01D-1683-08		6328607	134884824	27	17879											
PSIP1	11168	broad.mit.edu	37	chr9	15486860	15486860	+	Frame_Shift_Del	DEL	C	-	-																															ttcttcatggtcggtatcttCctttgaaacactagtttcct																										TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr9:15486860delC	uc003zlv.3	-	5	688	c.358delG	c.(358-360)GAAfs	p.E120fs	PSIP1_uc003zlw.3_Frame_Shift_Del_p.E120fs|PSIP1_uc003zlz.3_Frame_Shift_Del_p.E120fs|PSIP1_uc003zma.3_Frame_Shift_Del_p.E120fs|PSIP1_uc003zly.2_Frame_Shift_Del_p.E120fs	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	120					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TCGGTATCTTCCTTTGAAACA	0.333													---	---	---								-	15486860	-	-	15486860	7	5	92	1	0	1	0	1	0	0	0	0	12725	864	30	0	1311	0	PSIP1	9	15486860	Frame_Shift_Del	DEL	C	TCGA-CQ-5325-01A-01D-1683-08	9158253	15486860	125726571	28	17880											
HSD17B3	3293	broad.mit.edu	37	chr9	98997827	98997827	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caccgctgtagaaggcccagGccgggatcaggctcagaaag	11	4	14	12	2	2	2	2	0	0	2	2	3	2	3	3	4	0	3	3	4	3	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr9:98997827G>T	uc004awa.1	-	11	896	c.848C>A	c.(847-849)GCC>GAC	p.A283D	HSD17B3_uc010msc.1_Missense_Mutation_p.A233D	NM_000197	NP_000188	P37058	DHB3_HUMAN	estradiol 17 beta-dehydrogenase 3	283					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity				0		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	GAAGGCCCAGGCCGGGATCAG	0.527													6	17					8.12818e-05	9.00691e-05	1	0	T	98997827	T	T	98997827	3	4	92	1	0	0	0	0	1	0	0	0	7424	1203	42	4	88	4	HSD17B3	9	98997827	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	83510967	98997827	42215604	29	17881											
GALNT12	79695	broad.mit.edu	37	chr9	101599413	101599413	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagctctactaccatcgcAacccccgtgcccgcttggtg	8	8	9	16	3	1	1	0	0	1	1	2	1	1	1	4	1	5	3	4	1	4	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr9:101599413A>C	uc004ayz.2	+	6	1195	c.1195A>C	c.(1195-1197)AAC>CAC	p.N399H		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	399	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				CTACCATCGCAACCCCCGTGC	0.547													7	114					0	0	0	0	C	101599413	C	C	101599413	3	2	92	1	0	0	0	0	1	0	0	0	6245	130	5	5	1217	5	GALNT12	9	101599413	Missense_Mutation	SNP	A	TCGA-CQ-5325-01A-01D-1683-08	2601586	101599413	39614018	30	17882											
IDE	3416	broad.mit.edu	37	chr10	94268582	94268582	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatttgtagtatttctgaagGtcaggtatgggaaatgtcac	11	14	12	4	0	3	1	2	1	1	0	3	3	3	2	0	3	0	3	0	3	5	5			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr10:94268582G>C	uc001kia.2	-	7	1039	c.963C>G	c.(961-963)GAC>GAG	p.D321E		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	321					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATTTCTGAAGGTCAGGTATGG	0.363													11	112					0	0	0	0	C	94268582	C	C	94268582	3	2	92	1	0	0	0	0	1	0	0	0	7532	1252	44	4	2172	4	IDE	10	94268582	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08		94268582	41266165	31	17883											
COL17A1	1308	broad.mit.edu	37	chr10	105821185	105821185	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggaggtggaaacgccagtGttcacagccgcaggactctg	9	6	15	11	3	2	0	1	0	1	0	2	3	2	3	2	4	2	2	2	4	1	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr10:105821185G>A	uc001kxr.2	-	13	1126	c.957C>T	c.(955-957)AAC>AAT	p.N319N	COL17A1_uc010qqv.1_Silent_p.N303N	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	319	Cytoplasmic (Potential).|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AAACGCCAGTGTTCACAGCCG	0.577													5	25					0	0	0	0	A	105821185	A	A	105821185	2	1	92	1	0	0	0	0	0	0	0	1	3689	1368	48	4		4	COL17A1	10	105821185	Silent	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	11552603	105821185	29713562	32	17884											
DCLRE1A	9937	broad.mit.edu	37	chr10	115601164	115601164	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acatatctcttgaatgcttaCcttaaaattaatttgcatca	14	16	3	8	0	2	1	1	1	1	0	3	1	2	1	1	0	3	2	1	0	6	6			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr10:115601164C>G	uc001law.2	-	7	3738	c.2820_splice	c.e7+1	p.K940_splice		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A						cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		TGAATGCTTACCTTAAAATTA	0.323								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					4	48					0	0	0	0	G	115601164	G	G	115601164	5	3	92	1	0	0	0	0	0	0	1	0	4311	521	18	4	313	4	DCLRE1A	10	115601164	Splice_Site	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	9779979	115601164	19933583	33	17885											
DMBT1	1755	broad.mit.edu	37	chr10	124389869	124389869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggatcattgaatagcaGtctcctgctggggaaaatct	11	12	11	7	0	3	2	1	2	2	0	4	4	3	4	1	3	2	2	1	3	4	2			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr10:124389869G>A	uc001lgk.1	+	45	5607	c.5501G>A	c.(5500-5502)AGT>AAT	p.S1834N	DMBT1_uc001lgl.1_Missense_Mutation_p.S1824N|DMBT1_uc001lgm.1_Missense_Mutation_p.S1206N|DMBT1_uc009xzz.1_Missense_Mutation_p.S1834N|DMBT1_uc010qtx.1_Missense_Mutation_p.S554N|DMBT1_uc009yab.1_Missense_Mutation_p.S537N|DMBT1_uc009yac.1_Missense_Mutation_p.S128N	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1834	CUB 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTGAATAGCAGTCTCCTGCTG	0.368													4	60					0	0	0	0	A	124389869	A	A	124389869	3	1	92	1	0	0	0	0	1	0	0	0	4599	1029	36	4	5679	4	DMBT1	10	124389869	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	8788705	124389869	11144878	34	17886											
CCKBR	887	broad.mit.edu	37	chr11	6290927	6290927	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggccattagaatcactctTtacgcagtgatcttcctgat	9	14	7	11	1	3	3	1	2	2	1	4	3	4	3	2	1	1	1	2	1	3	4			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr11:6290927T>G	uc001mcp.2	+	2	373	c.180T>G	c.(178-180)CTT>CTG	p.L60L	CCKBR_uc001mcq.2_5'UTR|CCKBR_uc001mcr.2_Silent_p.L60L|CCKBR_uc001mcs.2_Silent_p.L60L	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	60	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GAATCACTCTTTACGCAGTGA	0.532													7	71					0	0	0	0	G	6290927	G	G	6290927	2	3	92	1	0	0	0	0	0	0	0	1	2894	1828	64	5		5	CCKBR	11	6290927	Silent	SNP	T	TCGA-CQ-5325-01A-01D-1683-08		6290927	128715589	35	17887											
DAK	26007	broad.mit.edu	37	chr11	61105464	61105464	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgtgctgatgacgctcttGctggcctggtggcctgcaac	4	11	14	12	1	1	2	0	2	1	0	1	2	1	2	2	3	4	5	2	3	1	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr11:61105464G>A	uc001nre.2	+	3	312	c.55G>A	c.(55-57)GCT>ACT	p.A19T	DDB1_uc010rlf.1_Intron|DAK_uc009ynm.1_5'UTR	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	19	DhaK.			A -> S (in Ref. 3; BAD97300).	glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						TGACGCTCTTGCTGGCCTGGT	0.622													17	95					0	0	0	0	A	61105464	A	A	61105464	3	1	92	1	0	0	0	0	1	0	0	0	4245	1319	46	4	61	4	DAK	11	61105464	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	54814537	61105464	73901052	36	17888											
CDK2AP2	10263	broad.mit.edu	37	chr11	67274859	67274859	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcaggcgctccatggcgCtcttgctgccagcataggta	6	11	11	13	2	3	0	1	0	2	0	4	0	4	0	2	3	3	5	2	3	2	4			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr11:67274859C>T	uc001oma.2	-	3	839	c.290G>A	c.(289-291)AGC>AAC	p.S97N	PITPNM1_uc001oly.2_5'Flank|PITPNM1_uc001olz.2_5'Flank|CDK2AP2_uc009yry.2_RNA|CDK2AP2_uc001omb.2_Missense_Mutation_p.S106N	NM_005851	NP_005842	O75956	CDKA2_HUMAN	cyclin-dependent kinase 2 associated protein 2	97											0						CTCCATGGCGCTCTTGCTGCC	0.607													12	92					0	0	0	0	T	67274859	T	T	67274859	3	4	92	1	0	0	0	0	1	0	0	0	3154	797	28	4	98	4	CDK2AP2	11	67274859	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	6169395	67274859	67731657	37	17889											
ZW10	9183	broad.mit.edu	37	chr11	113609058	113609058	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaaagttcctagcacttgaTaatctttccagaagttcacc	13	12	6	10	0	2	2	1	1	1	1	4	3	4	2	3	0	1	3	3	0	5	6			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr11:113609058T>A	uc001poe.2	-	13	1849	c.1812A>T	c.(1810-1812)TTA>TTT	p.L604F	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	604					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TAGCACTTGATAATCTTTCCA	0.403													11	49					0	0	0	0	A	113609058	A	A	113609058	3	1	92	1	0	0	0	0	1	0	0	0	18314	1403	49	5	543	5	ZW10	11	113609058	Missense_Mutation	SNP	T	TCGA-CQ-5325-01A-01D-1683-08	46334199	113609058	21397458	38	17890											
CDKN1B	1027	broad.mit.edu	37	chr12	12871015	12871015	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgagtggcaagaggtggagaAgggcagcttgcccgagttct	9	7	17	8	2	1	2	0	0	1	2	1	5	1	2	1	4	2	4	1	4	2	2			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr12:12871015A>G	uc001rat.2	+	1	714	c.242A>G	c.(241-243)AAG>AGG	p.K81R		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	81					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		GAGGTGGAGAAGGGCAGCTTG	0.612									Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				9	86					0	0	0	0	G	12871015	G	G	12871015	3	3	92	1	0	0	0	0	1	0	0	0	3174	72	3	5	244	5	CDKN1B	12	12871015	Missense_Mutation	SNP	A	TCGA-CQ-5325-01A-01D-1683-08		12871015	120980880	39	17891											
IFLTD1	160492	broad.mit.edu	37	chr12	25671777	25671777	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtcctgggctgtctatccaAtctgcctccagcggtggatg	6	11	12	12	1	2	0	0	0	2	0	5	1	5	1	4	3	2	1	4	3	2	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr12:25671777A>G	uc001rgs.2	-	7	1228	c.1078T>C	c.(1078-1080)TTG>CTG	p.L360L	IFLTD1_uc001rgt.1_Silent_p.L263L|IFLTD1_uc010sji.1_Silent_p.L381L|IFLTD1_uc010sjj.1_Silent_p.L297L|IFLTD1_uc009zjc.2_Silent_p.L341L	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	360						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					TGTCTATCCAATCTGCCTCCA	0.517											OREG0031252	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	6	73					0	0	0	0	G	25671777	G	G	25671777	2	3	92	1	0	0	0	0	0	0	0	1	7569	98	4	5		5	IFLTD1	12	25671777	Silent	SNP	A	TCGA-CQ-5325-01A-01D-1683-08	12800762	25671777	108180118	40	17892											
CORO1C	23603	broad.mit.edu	37	chr12	109051107	109051107	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagagagccagctgccgctcGctcatgcggctgaacccagt	8	6	12	15	3	1	2	1	1	0	1	2	3	1	2	3	1	5	4	3	1	1	0			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr12:109051107G>C	uc001tnj.2	-	6	819	c.723C>G	c.(721-723)AGC>AGG	p.S241R	CORO1C_uc009zva.2_Missense_Mutation_p.S294R|CORO1C_uc010sxf.1_Missense_Mutation_p.S204R	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	241					actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						GCTGCCGCTCGCTCATGCGGC	0.562													9	60					0	0	0	0	C	109051107	C	C	109051107	3	2	92	1	0	0	0	0	1	0	0	0	3770	1078	38	3	725	3	CORO1C	12	109051107	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	83379330	109051107	24800788	41	17893											
OAS1	4938	broad.mit.edu	37	chr12	113348885	113348885	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggcggctataaacctaacCcccaaatctatgtcaagctc	12	9	6	14	1	2	0	1	0	1	0	3	0	2	0	3	2	3	2	3	2	7	4			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr12:113348885C>T	uc001tud.2	+	3	605	c.499C>T	c.(499-501)CCC>TCC	p.P167S	OAS1_uc010syn.1_Missense_Mutation_p.P166S|OAS1_uc010syo.1_Intron|OAS1_uc001tub.2_Missense_Mutation_p.P167S|OAS1_uc001tuc.2_Missense_Mutation_p.P167S|OAS1_uc009zwf.2_Missense_Mutation_p.P166S	NM_016816	NP_058132	P00973	OAS1_HUMAN	2',5'-oligoadenylate synthetase 1 isoform 1	167					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(2)	2						TAAACCTAACCCCCAAATCTA	0.498													3	30					0	0	0	0	T	113348885	T	T	113348885	3	4	92	1	0	0	0	0	1	0	0	0	10853	623	22	4	509	4	OAS1	12	113348885	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	4297778	113348885	20503010	42	17894											
POP5	51367	broad.mit.edu	37	chr12	121017178	121017178	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctcctcctctaataagcaGcttcttgtcacagacttctg	8	14	5	14	0	4	1	1	0	3	1	7	1	7	1	3	0	2	2	3	0	2	5			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr12:121017178G>T	uc001tys.2	-	5	467	c.435C>A	c.(433-435)AGC>AGA	p.S145R	POP5_uc001tyt.2_Missense_Mutation_p.S95R	NM_015918	NP_057002	Q969H6	POP5_HUMAN	processing of precursor 5 isoform a	145					tRNA processing		protein binding|ribonuclease P activity				0	all_neural(191;0.077)|Medulloblastoma(191;0.0922)					CTAATAAGCAGCTTCTTGTCA	0.512													9	83					0.00448238	0.00477344	1	0	T	121017178	T	T	121017178	3	4	92	1	0	0	0	0	1	0	0	0	12308	962	34	4	60	4	POP5	12	121017178	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	7668293	121017178	12834717	43	17895											
PITPNM2	57605	broad.mit.edu	37	chr12	123475222	123475222	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaggagggggcgccatgctcTtggaaggctgcattgtgggt	6	9	19	7	1	1	0	0	0	1	0	1	3	1	2	1	6	2	3	1	6	1	2			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr12:123475222T>C	uc001uej.1	-	16	2578	c.2439A>G	c.(2437-2439)CAA>CAG	p.Q813Q	PITPNM2_uc001uek.1_Silent_p.Q861Q	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	813	DDHD.				metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CGCCATGCTCTTGGAAGGCTG	0.672													3	31					0	0	0	0	C	123475222	C	C	123475222	2	2	92	1	0	0	0	0	0	0	0	1	12006	1606	56	5		5	PITPNM2	12	123475222	Silent	SNP	T	TCGA-CQ-5325-01A-01D-1683-08	2458044	123475222	10376673	44	17896											
BRCA2	675	broad.mit.edu	37	chr13	32913306	32913306	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caataatgataaaaaccttgTttctattgagactgtggtgc	13	14	8	6	0	1	2	0	2	1	1	1	3	1	2	1	1	2	1	1	1	6	6			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr13:32913306T>A	uc001uub.1	+	11	5041	c.4814T>A	c.(4813-4815)GTT>GAT	p.V1605D		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1605					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAAAACCTTGTTTCTATTGAG	0.343			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			4	75					0	0	0	0	A	32913306	A	A	32913306	3	1	92	1	0	0	0	0	1	0	0	0	1504	1725	60	5	4852	5	BRCA2	13	32913306	Missense_Mutation	SNP	T	TCGA-CQ-5325-01A-01D-1683-08		32913306	82256572	45	17897											
OR4K15	81127	broad.mit.edu	37	chr14	20443692	20443692	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaacccatgctcacttcattAactgatctctgtttctctcc	9	15	3	14	0	4	1	2	1	2	0	7	1	5	1	2	0	3	2	2	0	2	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr14:20443692A>C	uc010tkx.1	+	1	15	c.15A>C	c.(13-15)TTA>TTC	p.L5F		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCACTTCATTAACTGATCTCT	0.363													3	57					0	0	0	0	C	20443692	C	C	20443692	3	2	92	1	0	0	0	0	1	0	0	0	11124	359	13	5	17	5	OR4K15	14	20443692	Missense_Mutation	SNP	A	TCGA-CQ-5325-01A-01D-1683-08		20443692	86905848	46	17898											
CCNB1IP1	57820	broad.mit.edu	37	chr14	20779905	20779905	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatccaaaggaaacttggagTtgttacctagggcagaaaaa	16	9	10	6	0	0	1	0	0	0	1	1	3	1	3	2	3	2	3	2	3	7	5			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr14:20779905T>C	uc001vwv.2	-	7	1287	c.638A>G	c.(637-639)AAC>AGC	p.N213S	CCNB1IP1_uc001vww.2_Missense_Mutation_p.N213S|CCNB1IP1_uc001vwx.2_Missense_Mutation_p.N213S|CCNB1IP1_uc001vwy.2_Missense_Mutation_p.N213S|CCNB1IP1_uc001vwz.2_Missense_Mutation_p.N213S	NM_182851	NP_878271	Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1 isoform 3	213						chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	soft_tissue(2)|ovary(1)	3	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)		AAACTTGGAGTTGTTACCTAG	0.343			T	HMGA2	leiomyoma								8	51					0	0	0	0	C	20779905	C	C	20779905	3	2	92	1	0	0	0	0	1	0	0	0	2927	1725	60	5	199	5	CCNB1IP1	14	20779905	Missense_Mutation	SNP	T	TCGA-CQ-5325-01A-01D-1683-08	336213	20779905	86569635	47	17899											
SCFD1	23256	broad.mit.edu	37	chr14	31122764	31122764	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actcctttacatcatacttgGacatatcaagcattggtgca	12	13	6	10	0	2	0	2	0	0	0	3	1	3	1	1	2	4	2	1	2	4	6			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr14:31122764G>A	uc001wqm.1	+	10	849	c.825G>A	c.(823-825)TGG>TGA	p.W275*	SCFD1_uc001wqn.1_Nonsense_Mutation_p.W208*|SCFD1_uc010tpg.1_Nonsense_Mutation_p.W216*|SCFD1_uc010tph.1_Nonsense_Mutation_p.W90*|SCFD1_uc010amf.1_Nonsense_Mutation_p.W90*|SCFD1_uc010tpi.1_Nonsense_Mutation_p.W183*|SCFD1_uc010amd.1_Nonsense_Mutation_p.W107*|SCFD1_uc010ame.1_Nonsense_Mutation_p.W208*	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	275					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		ATCATACTTGGACATATCAAG	0.328													5	91					0	0	0	0	A	31122764	A	A	31122764	4	1	92	1	0	0	0	0	0	1	0	0	13954	1183	41	2	863	2	SCFD1	14	31122764	Nonsense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	10342859	31122764	76226776	48	17900											
HERPUD1	9709	broad.mit.edu	37	chr16	56973962	56973962	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctcctcaagtggttgttaAtcctggagccaatcaaaatt	11	13	8	9	0	2	0	2	0	0	0	4	1	4	1	3	2	2	3	3	2	5	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr16:56973962A>T	uc002eke.1	+	6	1119	c.710A>T	c.(709-711)AAT>ATT	p.N237I	HERPUD1_uc002ekf.1_Missense_Mutation_p.N236I|HERPUD1_uc002ekg.1_Missense_Mutation_p.N212I|HERPUD1_uc010cco.1_Missense_Mutation_p.N298I|HERPUD1_uc010ccp.1_Intron|HERPUD1_uc002ekh.1_Missense_Mutation_p.N55I	NM_014685	NP_055500	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum	237	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0						GTGGTTGTTAATCCTGGAGCC	0.463			T	ERG	prostate								4	29					0	0	0	0	T	56973962	T	T	56973962	3	4	92	1	0	0	0	0	1	0	0	0	7102	101	4	5	732	5	HERPUD1	16	56973962	Missense_Mutation	SNP	A	TCGA-CQ-5325-01A-01D-1683-08		56973962	33380791	49	17901											
WWOX	51741	broad.mit.edu	37	chr16	78466645	78466645	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcgaggcctttcaccaagtCcatggtaagagaacagcttc	11	8	11	11	1	1	1	1	0	0	1	3	3	2	1	3	3	2	2	3	3	3	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr16:78466645C>A	uc002ffk.2	+	8	1177	c.1052C>A	c.(1051-1053)TCC>TAC	p.S351Y	WWOX_uc010vnk.1_Missense_Mutation_p.S238Y|WWOX_uc002ffl.2_Intron|WWOX_uc010che.2_Intron	NM_016373	NP_057457	Q9NZC7	WWOX_HUMAN	WW domain-containing oxidoreductase isoform 1	351	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity				0		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TTCACCAAGTCCATGGTAAGA	0.512													16	207					4.14922e-12	5.07815e-12	1	0	A	78466645	A	A	78466645	3	1	92	1	0	0	0	0	1	0	0	0	17482	855	30	2	1144	2	WWOX	16	78466645	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	21492683	78466645	11888108	50	17902											
ZNF276	92822	broad.mit.edu	37	chr16	89789965	89789965	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccctggggatgcccctcagaCctcccagggtagagggacag	8	5	14	14	0	1	2	1	0	0	2	2	4	2	4	5	4	1	1	5	4	1	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr16:89789965C>T	uc002fos.3	+	4	951	c.854C>T	c.(853-855)ACC>ATC	p.T285I	C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_Missense_Mutation_p.P82S|ZNF276_uc002fop.2_Missense_Mutation_p.P204S|ZNF276_uc002foq.3_Missense_Mutation_p.T210I|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_Missense_Mutation_p.P82S|ZNF276_uc010cis.2_Missense_Mutation_p.T44I|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_Missense_Mutation_p.T123I|ZNF276_uc010cit.1_Missense_Mutation_p.T44I	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GCCCCTCAGACCTCCCAGGGT	0.677													5	48					0	0	0	0	T	89789965	T	T	89789965	3	4	92	1	0	0	0	0	1	0	0	0	17878	507	18	4	868	4	ZNF276	16	89789965	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	11323320	89789965	564788	51	17903											
COPS3	8533	broad.mit.edu	37	chr17	17150427	17150427	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtttcaagaataactggaTggtttgtttcctgaatcatc	11	16	8	6	0	2	2	2	1	0	1	4	3	3	3	1	2	1	3	1	2	5	5			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr17:17150427T>A	uc002grd.2	-	12	1348	c.1257A>T	c.(1255-1257)CCA>CCT	p.P419P	COPS3_uc010vwv.1_Silent_p.P399P|COPS3_uc010vww.1_Silent_p.P289P	NM_003653	NP_003644	Q9UNS2	CSN3_HUMAN	COP9 constitutive photomorphogenic homolog	419					cullin deneddylation|response to light stimulus|signal transduction	cytoplasm|signalosome	protein binding			skin(1)	1						AATAACTGGATGGTTTGTTTC	0.438													4	116					0	0	0	0	A	17150427	A	A	17150427	2	1	92	1	0	0	0	0	0	0	0	1	3749	1451	51	5		5	COPS3	17	17150427	Silent	SNP	T	TCGA-CQ-5325-01A-01D-1683-08		17150427	64044783	52	17904											
TNS4	84951	broad.mit.edu	37	chr17	38634851	38634851	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttccgttgctcagggtccaTaccacagaagcggagggtgg	8	8	14	11	2	1	1	1	0	0	1	3	2	3	2	3	4	3	2	3	4	2	3	rs147778475		TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr17:38634851T>A	uc010cxb.2	-	11	2124	c.1960A>T	c.(1960-1962)ATG>TTG	p.M654L	TNS4_uc002huu.3_Missense_Mutation_p.M67L	NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	654	Phosphatase tensin-type.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			TCAGGGTCCATACCACAGAAG	0.617													8	59					0	0	0	0	A	38634851	A	A	38634851	3	1	92	1	0	0	0	0	1	0	0	0	16411	1406	49	5	199	5	TNS4	17	38634851	Missense_Mutation	SNP	T	TCGA-CQ-5325-01A-01D-1683-08	21484424	38634851	42560359	53	17905											
ALPK2	115701	broad.mit.edu	37	chr18	56204982	56204982	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatggtatcaaaacacgttcCttggtcaccagcctcaaaac	13	10	6	12	1	3	0	3	0	0	0	4	0	4	0	3	2	3	2	3	2	6	4			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr18:56204982C>T	uc002lhj.3	-	5	2651	c.2437G>A	c.(2437-2439)GGA>AGA	p.G813R	ALPK2_uc002lhk.1_Missense_Mutation_p.G144R	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	813							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						AAACACGTTCCTTGGTCACCA	0.463													7	55					0	0	0	0	T	56204982	T	T	56204982	3	4	92	1	0	0	0	0	1	0	0	0	545	690	24	4	4111	4	ALPK2	18	56204982	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08		56204982	21872266	54	17906											
PLD3	23646	broad.mit.edu	37	chr19	40872532	40872532	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagctgaaggtgcctgcaGaggagcccgccaatgagctg	9	5	14	13	1	0	3	0	2	0	1	0	4	0	4	4	2	5	3	4	2	2	0			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr19:40872532G>T	uc002onm.3	+	4	441	c.43G>T	c.(43-45)GAG>TAG	p.E15*	PLD3_uc002onj.3_Nonsense_Mutation_p.E15*|PLD3_uc002onk.3_Nonsense_Mutation_p.E15*|PLD3_uc002onl.3_Nonsense_Mutation_p.E15*|PLD3_uc002onn.2_Nonsense_Mutation_p.E15*|PLD3_uc002ono.2_Nonsense_Mutation_p.E15*	NM_001031696	NP_001026866	Q8IV08	PLD3_HUMAN	phospholipase D3	15	Cytoplasmic (Potential).				lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			GGTGCCTGCAGAGGAGCCCGC	0.632													5	81					2.0095e-06	2.35398e-06	1	0	T	40872532	T	T	40872532	4	4	92	1	0	0	0	0	0	1	0	0	12102	943	33	2	49	2	PLD3	19	40872532	Nonsense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08		40872532	18256451	55	17907											
KIR3DL1	3811	broad.mit.edu	37	chr19	55341406	55341406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgctgtaatggaccaagagCctgcagggaacagaacagcc	13	5	12	11	0	0	2	0	0	0	2	0	4	0	4	3	2	6	3	3	2	4	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr19:55341406C>T	uc002qhk.3	+	8	1192	c.1129C>T	c.(1129-1131)CCT>TCT	p.P377S	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.P302S|KIR3DL1_uc010esf.2_Missense_Mutation_p.P282S|KIR3DL1_uc010yfo.1_Missense_Mutation_p.P319S|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_5'Flank|KIR2DS4_uc002qhm.1_5'Flank	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	377	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GGACCAAGAGCCTGCAGGGAA	0.532													14	112					0	0	0	0	T	55341406	T	T	55341406	3	4	92	1	0	0	0	0	1	0	0	0	8359	739	26	4	1159	4	KIR3DL1	19	55341406	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	14468874	55341406	3787577	56	17908											
CSNK2A1	1457	broad.mit.edu	37	chr20	470519	470519	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacatatccaaactataatCgtacatctgcataaaagtaa	18	10	3	10	1	1	0	0	0	1	0	3	0	2	0	2	0	3	3	2	0	8	6			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr20:470519C>T	uc002wdw.1	-	10	1021	c.628G>A	c.(628-630)GAT>AAT	p.D210N	CSNK2A1_uc002wdx.1_Missense_Mutation_p.D210N|CSNK2A1_uc002wdy.1_Missense_Mutation_p.D74N	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	210	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			AAACTATAATCGTACATCTGC	0.318													3	47					0	0	0	0	T	470519	T	T	470519	3	4	92	1	0	0	0	0	1	0	0	0	3974	884	31	1	567	1	CSNK2A1	20	470519	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08		470519	62555001	57	17909											
FAM65C	140876	broad.mit.edu	37	chr20	49204362	49204362	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acgacagtgtggtttcccggGctgccgcccgcacggcctcc	4	7	13	17	5	0	0	0	0	0	0	2	1	2	0	5	3	1	3	5	3	0	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr20:49204362G>T	uc002xvm.2	-	21	3035	c.2717C>A	c.(2716-2718)GCC>GAC	p.A906D	FAM65C_uc010zyt.1_Missense_Mutation_p.A910D	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	906										ovary(2)	2						GGTTTCCCGGGCTGCCGCCCG	0.592											OREG0026030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	57					0.000157383	0.000172072	1	0	T	49204362	T	T	49204362	3	4	92	1	0	0	0	0	1	0	0	0	5633	1203	42	4	131	4	FAM65C	20	49204362	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	48733843	49204362	13821158	58	17910											
CARD10	29775	broad.mit.edu	37	chr22	37914082	37914082	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaaggcctcatagcccctcTtgccacggcagcgcaagatg	9	6	12	14	2	2	1	1	0	1	1	2	2	2	2	4	3	3	2	4	3	3	2			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chr22:37914082T>A	uc003asx.1	-	2	272	c.269A>T	c.(268-270)AAG>ATG	p.K90M	CARD10_uc003ast.1_RNA|CARD10_uc003asy.1_Missense_Mutation_p.K90M	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	90	CARD.				activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					ATAGCCCCTCTTGCCACGGCA	0.627													6	49					0	0	0	0	A	37914082	A	A	37914082	3	1	92	1	0	0	0	0	1	0	0	0	2656	1609	56	5	2905	5	CARD10	22	37914082	Missense_Mutation	SNP	T	TCGA-CQ-5325-01A-01D-1683-08		37914082	13390484	59	17911											
DMD	1756	broad.mit.edu	37	chrX	31947847	31947847	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aattccctggcgcaggggcaActcttccaccagtaactgaa	11	8	9	13	1	1	1	0	1	1	0	3	1	3	1	3	3	2	3	3	3	4	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chrX:31947847A>G	uc004dda.1	-	47	7022	c.6778T>C	c.(6778-6780)TTG>CTG	p.L2260L	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Silent_p.L916L|DMD_uc004dcx.2_Silent_p.L919L|DMD_uc004dcz.2_Silent_p.L2137L|DMD_uc004dcy.1_Silent_p.L2256L|DMD_uc004ddb.1_Silent_p.L2252L|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2260	Spectrin 16.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CGCAGGGGCAACTCTTCCACC	0.403													11	29					0	0	0	0	G	31947847	G	G	31947847	2	3	92	1	0	0	0	0	0	0	0	1	4602	40	2	5		5	DMD	23	31947847	Silent	SNP	A	TCGA-CQ-5325-01A-01D-1683-08		31947847	123322713	60	17912											
MAGEE1	57692	broad.mit.edu	37	chrX	75648934	75648934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctccgtgctgcctacacCtggtgagggaccaggcacct	7	7	11	16	1	0	1	0	1	0	0	1	2	1	2	6	3	3	2	6	3	1	1			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chrX:75648934C>T	uc004ecm.1	+	1	818	c.611C>T	c.(610-612)CCT>CTT	p.P204L		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	204	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CTGCCTACACCTGGTGAGGGA	0.687													4	13					0	0	0	0	T	75648934	T	T	75648934	3	4	92	1	0	0	0	0	1	0	0	0	9238	681	24	4	613	4	MAGEE1	23	75648934	Missense_Mutation	SNP	C	TCGA-CQ-5325-01A-01D-1683-08	43701087	75648934	79621626	61	17913											
PABPC5	140886	broad.mit.edu	37	chrX	90691201	90691201	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgttaaaaacattggagacGacatagatgacgaaaaactg	18	8	9	6	3	0	3	0	1	0	2	1	6	0	3	0	1	2	1	0	1	6	3			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chrX:90691201G>A	uc004efg.2	+	2	1065	c.625G>A	c.(625-627)GAC>AAC	p.D209N	PABPC5_uc004eff.1_Missense_Mutation_p.D45N	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	209	RRM 3.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CATTGGAGACGACATAGATGA	0.428													5	21					0	0	0	0	A	90691201	A	A	90691201	3	1	92	1	0	0	0	0	1	0	0	0	11421	1058	37	1	627	1	PABPC5	23	90691201	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	15042267	90691201	64579359	62	17914											
IGSF1	3547	broad.mit.edu	37	chrX	130409627	130409627	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtggcttctccttctttGtgcagaatgtatcctactcc	7	15	8	11	0	2	1	0	0	2	1	5	2	4	1	3	1	2	3	3	1	4	5			TCGA-CQ-5325-01A-01D-1683-08	TCGA-CQ-5325-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b6abf5-aad8-46ab-9b87-e3c12309cb59	e385057a-e79d-480f-909f-5f978b1e28ab	g.chrX:130409627G>T	uc004ewd.2	-	16	3247	c.3009C>A	c.(3007-3009)CAC>CAA	p.H1003Q	IGSF1_uc004ewe.3_Missense_Mutation_p.H997Q|IGSF1_uc004ewf.2_Missense_Mutation_p.H983Q	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1003	Extracellular (Potential).|Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CTCCTTCTTTGTGCAGAATGT	0.527													10	47					9.31168e-06	1.07543e-05	1	0	T	130409627	T	T	130409627	3	4	92	1	0	0	0	0	1	0	0	0	7635	1368	48	4	1021	4	IGSF1	23	130409627	Missense_Mutation	SNP	G	TCGA-CQ-5325-01A-01D-1683-08	39718426	130409627	24860933	63	17915											
PRKCZ	5590	broad.mit.edu	37	chr1	2077510	2077510	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctccagtagacgacaagaaCgaggacgccgaccttccttc	11	6	9	15	4	0	2	0	0	0	2	3	6	2	3	5	1	1	1	5	1	3	3	rs150712752		TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:2077510C>T	uc001aiq.2	+	7	758	c.597C>T	c.(595-597)AAC>AAT	p.N199N	PRKCZ_uc001air.2_Silent_p.N16N|PRKCZ_uc010nyw.1_Silent_p.N95N|PRKCZ_uc001ais.2_Silent_p.N16N|PRKCZ_uc009vla.2_Silent_p.N23N|PRKCZ_uc010nyx.1_RNA|PRKCZ_uc009vlb.2_Silent_p.N12N	NM_002744	NP_002735	Q05513	KPCZ_HUMAN	protein kinase C, zeta isoform 1	199					anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		ACGACAAGAACGAGGACGCCG	0.577													24	51					0	0	0	0	T	2077510	T	T	2077510	2	4	93	1	0	0	0	0	0	0	0	1	12579	535	19	1		1	PRKCZ	1	2077510	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		2077510	247173111	1	17916											
MMEL1	79258	broad.mit.edu	37	chr1	2523445	2523445	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgctggtccttgccaccctCtgccatccacttgaggtagg	5	11	10	15	0	1	1	0	1	1	0	3	1	3	1	5	3	3	2	5	3	1	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:2523445C>G	uc001ajy.2	-	22	2303	c.2089G>C	c.(2089-2091)GAG>CAG	p.E697Q	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	697	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		TTGCCACCCTCTGCCATCCAC	0.627													28	48					0	0	0	0	G	2523445	G	G	2523445	3	3	93	1	0	0	0	0	1	0	0	0	9699	922	32	2	262	2	MMEL1	1	2523445	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	445935	2523445	246727176	2	17917											
PRDM16	63976	broad.mit.edu	37	chr1	3334404	3334404	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctacagatgtcagccataGagaccatgacagagaagctg	14	6	11	10	0	1	4	1	1	0	3	1	6	1	4	3	0	3	1	3	0	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:3334404G>T	uc001akf.2	+	11	2784	c.2704G>T	c.(2704-2706)GAG>TAG	p.E902*	PRDM16_uc001akc.2_Nonsense_Mutation_p.E901*|PRDM16_uc001akd.2_Nonsense_Mutation_p.E901*|PRDM16_uc001ake.2_Nonsense_Mutation_p.E902*|PRDM16_uc009vlh.2_Nonsense_Mutation_p.E602*	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	902	Mediates interaction with SKI and regulation of TGF-beta signaling.|Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GTCAGCCATAGAGACCATGAC	0.592			T	EVI1	MDS|AML								59	226					1.1362e-29	1.27156e-29	1	0	T	3334404	T	T	3334404	4	4	93	1	0	0	0	0	0	1	0	0	12519	943	33	2	2746	2	PRDM16	1	3334404	Nonsense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	810959	3334404	245916217	3	17918											
PLEKHG5	57449	broad.mit.edu	37	chr1	6528529	6528529	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagatgaggcagtggtgctGagagaggtctcatcagactg	10	8	16	7	0	2	5	2	2	1	3	3	6	2	5	0	3	1	3	0	3	0	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:6528529G>C	uc001ano.1	-	21	2636	c.2535C>G	c.(2533-2535)CTC>CTG	p.L845L	PLEKHG5_uc001ann.1_Silent_p.L826L|PLEKHG5_uc001anq.1_Intron|PLEKHG5_uc001anp.1_Silent_p.L866L|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Silent_p.L350L|PLEKHG5_uc009vma.1_Silent_p.L629L|PLEKHG5_uc010nzr.1_Silent_p.L858L|PLEKHG5_uc001ank.1_Silent_p.L789L|PLEKHG5_uc009vmb.1_Silent_p.L789L|PLEKHG5_uc001anl.1_Silent_p.L789L|PLEKHG5_uc001anm.1_Silent_p.L789L|PLEKHG5_uc001anr.1_Silent_p.L52L	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	845					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CAGTGGTGCTGAGAGAGGTCT	0.652													12	39					0	0	0	0	C	6528529	C	C	6528529	2	2	93	1	0	0	0	0	0	0	0	1	12128	1277	45	2		2	PLEKHG5	1	6528529	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3194125	6528529	242722092	4	17919											
KIF1B	23095	broad.mit.edu	37	chr1	10434488	10434488	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggaaaaaacgaatttctCaatcttgttccagatattga	15	12	7	7	1	2	2	1	1	2	1	4	4	3	3	1	1	1	2	1	1	6	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:10434488C>T	uc001aqx.3	+	46	5263	c.5061C>T	c.(5059-5061)CTC>CTT	p.L1687L	KIF1B_uc001aqw.3_Silent_p.L1641L|KIF1B_uc001aqy.2_Silent_p.L1661L|KIF1B_uc001aqz.2_Silent_p.L1687L|KIF1B_uc001ara.2_Silent_p.L1647L|KIF1B_uc001arb.2_Silent_p.L1673L	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	1687					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ACGAATTTCTCAATCTTGTTC	0.433													60	106					0	0	0	0	T	10434488	T	T	10434488	2	4	93	1	0	0	0	0	0	0	0	1	8323	813	29	2		2	KIF1B	1	10434488	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	3905959	10434488	238816133	5	17920											
NBPF1	55672	broad.mit.edu	37	chr1	16893673	16893673	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccttcatagaaaggtactcaCcatccatgtcaagagcccag	13	8	7	13	0	3	2	3	0	0	2	4	2	4	2	4	1	2	1	4	1	4	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:16893673C>A	uc009vos.1	-	26	3952	c.3064_splice	c.e26+1	p.R1022_splice	NBPF1_uc009vot.1_Splice_Site_p.E405_splice|NBPF1_uc001ayz.1_Splice_Site_p.E405_splice	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AAGGTACTCACCATCCATGTC	0.468													20	894					1.9806e-07	2.10269e-07	1	0	A	16893673	A	A	16893673	5	1	93	1	0	0	0	0	0	0	1	0	10245	521	18	4	604	4	NBPF1	1	16893673	Splice_Site	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	6459185	16893673	232356948	6	17921											
MAN1C1	57134	broad.mit.edu	37	chr1	25944444	25944444	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctctcgcctcaagcgcctCttcctggccccccggaccca	4	8	7	22	3	3	0	1	0	2	0	6	1	5	1	8	2	1	0	8	2	1	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:25944444C>G	uc001bkm.2	+	1	486	c.156C>G	c.(154-156)CTC>CTG	p.L52L	MAN1C1_uc009vry.1_5'UTR	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	52	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		TCAAGCGCCTCTTCCTGGCCC	0.657													7	51					0	0	0	0	G	25944444	G	G	25944444	2	3	93	1	0	0	0	0	0	0	0	1	9266	900	32	2		2	MAN1C1	1	25944444	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	9050771	25944444	223306177	7	17922											
MAN1C1	57134	broad.mit.edu	37	chr1	25944475	25944475	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccggacccagcagcctggtCtggaagtggtggctgaaatc	8	7	14	12	1	1	1	0	1	1	0	2	3	1	3	3	5	2	2	3	5	2	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:25944475C>G	uc001bkm.2	+	1	517	c.187C>G	c.(187-189)CTG>GTG	p.L63V	MAN1C1_uc009vry.1_5'UTR	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	63	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GCAGCCTGGTCTGGAAGTGGT	0.602													4	38					0	0	0	0	G	25944475	G	G	25944475	3	3	93	1	0	0	0	0	1	0	0	0	9266	912	32	2	189	2	MAN1C1	1	25944475	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	31	25944475	223306146	8	17923											
BAI2	576	broad.mit.edu	37	chr1	32210289	32210289	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaggctcatctgcagacctCggccactgggttttcacttt	6	12	9	14	1	3	1	2	0	1	1	4	1	3	1	3	3	1	3	3	3	0	3	rs138537223	byFrequency	TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:32210289C>T	uc001btn.2	-	5	1236	c.882G>A	c.(880-882)CCG>CCA	p.P294P	BAI2_uc010ogo.1_5'UTR|BAI2_uc010ogp.1_Silent_p.P282P|BAI2_uc010ogq.1_Silent_p.P294P|BAI2_uc001bto.2_Silent_p.P294P|BAI2_uc001btq.1_Silent_p.P282P|BAI2_uc010ogr.1_Silent_p.P282P	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	294	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		CTGCAGACCTCGGCCACTGGG	0.627													11	36					0	0	0	0	T	32210289	T	T	32210289	2	4	93	1	0	0	0	0	0	0	0	1	1301	871	31	1		1	BAI2	1	32210289	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	6265814	32210289	217040332	9	17924											
YARS	8565	broad.mit.edu	37	chr1	33252028	33252028	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgtttccaccccatttctCatctcgtaggatcacaaact	9	15	4	13	1	3	0	2	0	2	0	6	1	4	1	3	1	1	2	3	1	2	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:33252028C>G	uc001bvy.1	-	8	1629	c.841G>C	c.(841-843)GAG>CAG	p.E281Q	YARS_uc001bvx.1_5'Flank	NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	281					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	CCCCATTTCTCATCTCGTAGG	0.428													13	39					0	0	0	0	G	33252028	G	G	33252028	3	3	93	1	0	0	0	0	1	0	0	0	17535	835	29	2	769	2	YARS	1	33252028	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	1041739	33252028	215998593	10	17925											
MACF1	23499	broad.mit.edu	37	chr1	39753030	39753030	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtaccggaagggtcatttCacttcacttgaattggttcc	8	14	9	10	1	3	1	3	1	0	0	4	2	4	2	2	3	1	2	2	3	3	6			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:39753030C>T	uc010ois.1	+	16	1801	c.1596C>T	c.(1594-1596)TTC>TTT	p.F532F	MACF1_uc001cda.1_Silent_p.F440F	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	532					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGGGTCATTTCACTTCACTTG	0.463													45	148					0	0	0	0	T	39753030	T	T	39753030	2	4	93	1	0	0	0	0	0	0	0	1	9195	825	29	2		2	MACF1	1	39753030	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	6501002	39753030	209497591	11	17926											
MACF1	23499	broad.mit.edu	37	chr1	39753073	39753073	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctactttaaccaccactCatctgaaagcagaaccctta	13	10	3	15	0	3	2	1	1	2	1	3	2	3	2	4	0	4	1	4	0	5	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:39753073C>G	uc010ois.1	+	16	1844	c.1639C>G	c.(1639-1641)CAT>GAT	p.H547D	MACF1_uc001cda.1_Missense_Mutation_p.H455D	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	547					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AACCACCACTCATCTGAAAGC	0.498													59	205					0	0	0	0	G	39753073	G	G	39753073	3	3	93	1	0	0	0	0	1	0	0	0	9195	826	29	2	1693	2	MACF1	1	39753073	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	43	39753073	209497548	12	17927											
MYSM1	114803	broad.mit.edu	37	chr1	59148058	59148058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgatgtctacttcttcatCatcagataacttttcaattt	10	19	4	8	0	6	2	4	1	2	1	6	2	6	2	0	0	2	0	0	0	3	7			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:59148058C>T	uc009wab.1	-	8	681	c.658G>A	c.(658-660)GAT>AAT	p.D220N	MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	220					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					ACTTCTTCATCATCAGATAAC	0.388													26	132					0	0	0	0	T	59148058	T	T	59148058	3	4	93	1	0	0	0	0	1	0	0	0	10154	826	29	2	1880	2	MYSM1	1	59148058	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	19394985	59148058	190102563	13	17928											
LRRC7	57554	broad.mit.edu	37	chr1	70505456	70505456	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacagctgcttagacatataGaagctagacggttagacagg	15	8	11	7	1	0	4	0	0	0	4	0	4	0	4	0	2	4	4	0	2	7	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:70505456G>C	uc001dep.2	+	19	3865	c.3835G>C	c.(3835-3837)GAA>CAA	p.E1279Q	LRRC7_uc009wbg.2_Missense_Mutation_p.E563Q|LRRC7_uc001deq.2_Missense_Mutation_p.E520Q	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1279						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TAGACATATAGAAGCTAGACG	0.438													26	127					0	0	0	0	C	70505456	C	C	70505456	3	2	93	1	0	0	0	0	1	0	0	0	9070	943	33	2	3909	2	LRRC7	1	70505456	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	11357398	70505456	178745165	14	17929											
DNAJB4	11080	broad.mit.edu	37	chr1	78470899	78470899	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaaatttcatccggacaaGaacaaatctcctcaggcaga	15	8	6	12	1	4	2	3	0	1	2	6	3	5	3	2	2	1	1	2	2	4	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:78470899G>C	uc001dij.2	+	1	264	c.105G>C	c.(103-105)AAG>AAC	p.K35N	DNAJB4_uc010orn.1_Intron	NM_007034	NP_008965	Q9UDY4	DNJB4_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 4	35	J.				protein folding|response to heat|response to unfolded protein	cytoplasm|plasma membrane	heat shock protein binding|unfolded protein binding				0						ATCCGGACAAGAACAAATCTC	0.373													3	118					0	0	0	0	C	78470899	C	C	78470899	3	2	93	1	0	0	0	0	1	0	0	0	4644	933	33	2	107	2	DNAJB4	1	78470899	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	7965443	78470899	170779722	15	17930											
ELTD1	64123	broad.mit.edu	37	chr1	79387472	79387472	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctatacctatctgtgacCtgaaaaaaagatactttact	14	13	4	10	0	1	3	0	2	1	1	2	3	2	3	3	0	3	0	3	0	8	6			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:79387472C>A	uc001diq.3	-	9	1240	c.1084_splice	c.e9-1	p.V362_splice		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain						neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TATCTGTGACCTGAAAAAAAG	0.353													7	34					1.26484e-09	1.35675e-09	1	0	A	79387472	A	A	79387472	5	1	93	1	0	0	0	0	0	0	1	0	5108	695	24	4	1017	4	ELTD1	1	79387472	Splice_Site	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	916573	79387472	169863149	16	17931											
PTBP2	58155	broad.mit.edu	37	chr1	97235416	97235416	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaccaacatccttatgctGaaaggaaaaaatcaggtaca	17	8	8	8	0	1	2	1	2	0	0	2	3	2	3	2	2	3	2	2	2	7	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:97235416G>C	uc001drq.2	+	4	519	c.273G>C	c.(271-273)CTG>CTC	p.L91L	PTBP2_uc001drn.2_Silent_p.L91L|PTBP2_uc001dro.2_Silent_p.L91L|PTBP2_uc010otz.1_Silent_p.L102L|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Silent_p.L39L|PTBP2_uc001drr.2_Silent_p.L91L|PTBP2_uc010oua.1_Silent_p.L99L|PTBP2_uc001dru.2_RNA|PTBP2_uc001drm.2_Silent_p.L91L	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	91	RRM 1.						nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		TCCTTATGCTGAAAGGAAAAA	0.368													31	81					0	0	0	0	C	97235416	C	C	97235416	2	2	93	1	0	0	0	0	0	0	0	1	12788	1277	45	2		2	PTBP2	1	97235416	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	17847944	97235416	152015205	17	17932											
SPRR2B	6701	broad.mit.edu	37	chr1	153043109	153043109	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaagctgttacttgctcttCggtggatactttggctggca	6	15	12	8	1	1	1	0	1	1	0	2	2	1	2	0	4	4	5	0	4	3	5	rs143849195	byFrequency	TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:153043109C>T	uc001fbg.2	-	2	270	c.207G>A	c.(205-207)CCG>CCA	p.P69P	SPRR2D_uc009wnz.2_Intron|SPRR2A_uc001fbf.2_Intron|SPRR2A_uc009woa.2_Intron	NM_001017418	NP_001017418	P35325	SPR2B_HUMAN	small proline-rich protein 2B	69					keratinization	cornified envelope|cytoplasm					0	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACTTGCTCTTCGGTGGATACT	0.532													60	176					0	0	0	0	T	153043109	T	T	153043109	2	4	93	1	0	0	0	0	0	0	0	1	15164	871	31	1		1	SPRR2B	1	153043109	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	55807693	153043109	96207512	18	17933											
RUSC1	23623	broad.mit.edu	37	chr1	155292131	155292131	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacgccctgaccacctgccaGgacgtcccttccccaggctt	7	7	8	19	2	0	1	0	1	0	0	2	2	2	2	7	2	2	1	7	2	1	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:155292131G>T	uc001fkj.2	+	2	796	c.567G>T	c.(565-567)CAG>CAT	p.Q189H	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_5'Flank|C1orf104_uc001fki.2_Intron|RUSC1_uc001fkk.2_Missense_Mutation_p.Q189H|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank|RUSC1_uc001fkn.2_5'Flank|RUSC1_uc001fko.2_5'Flank|RUSC1_uc001fkr.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	189						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			CCACCTGCCAGGACGTCCCTT	0.607													29	69					1.75199e-13	1.899e-13	1	0	T	155292131	T	T	155292131	3	4	93	1	0	0	0	0	1	0	0	0	13815	991	35	4	569	4	RUSC1	1	155292131	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	2249022	155292131	93958490	19	17934											
FAM78B	149297	broad.mit.edu	37	chr1	166039589	166039589	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttaggggggatgggttccatCcggctcaggatccggggctg	5	9	18	9	2	1	0	1	0	0	0	4	2	4	2	3	8	0	3	3	8	1	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:166039589C>T	uc001gdr.2	-	3	1265	c.675G>A	c.(673-675)CGG>CGA	p.R225R	FAM78B_uc010plc.1_RNA|FAM78B_uc001gdq.2_RNA	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	225										central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					TGGGTTCCATCCGGCTCAGGA	0.627													20	95					0	0	0	0	T	166039589	T	T	166039589	2	4	93	1	0	0	0	0	0	0	0	1	5659	842	30	2		2	FAM78B	1	166039589	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	10747458	166039589	83211032	20	17935											
LGR6	59352	broad.mit.edu	37	chr1	202287946	202287946	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccacttccgggatgaccttCggcggcttcggccccgcgca	4	7	12	18	6	0	1	0	1	0	0	3	2	1	2	5	4	0	2	5	4	0	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:202287946C>T	uc001gxu.2	+	18	2515	c.2515C>T	c.(2515-2517)CGG>TGG	p.R839W	LGR6_uc001gxv.2_Missense_Mutation_p.R787W|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.R700W	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	839	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						GGATGACCTTCGGCGGCTTCG	0.667													34	118					0	0	0	0	T	202287946	T	T	202287946	3	4	93	1	0	0	0	0	1	0	0	0	8799	875	31	1	2732	1	LGR6	1	202287946	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	36248357	202287946	46962675	21	17936											
OBSCN	84033	broad.mit.edu	37	chr1	228432096	228432096	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgaggtggcccaggcccAgacggaggtgacgtggtaca	8	6	17	10	2	0	3	0	2	0	1	0	4	0	4	2	6	1	1	2	6	1	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:228432096A>G	uc009xez.1	+	11	3349	c.3305A>G	c.(3304-3306)CAG>CGG	p.Q1102R	OBSCN_uc001hsn.2_Missense_Mutation_p.Q1102R	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1102	Ig-like 11.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCCCAGGCCCAGACGGAGGTG	0.597													9	87					0	0	0	0	G	228432096	G	G	228432096	3	3	93	1	0	0	0	0	1	0	0	0	10866	188	7	5	3343	5	OBSCN	1	228432096	Missense_Mutation	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	26144150	228432096	20818525	22	17937											
TRIM58	25893	broad.mit.edu	37	chr1	248028108	248028108	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagctgaggcggctggaggcGgaggagcgagcgacgctgca	8	3	20	10	5	0	1	0	1	0	0	0	6	0	4	0	6	4	4	0	6	0	0	rs147052726		TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr1:248028108G>A	uc001ido.2	+	3	666	c.618G>A	c.(616-618)GCG>GCA	p.A206A		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	206	Potential.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCTGGAGGCGGAGGAGCGAG	0.622													21	40					0	0	0	0	A	248028108	A	A	248028108	2	1	93	1	0	0	0	0	0	0	0	1	16598	1103	39	1		1	TRIM58	1	248028108	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	19596012	248028108	1222513	23	17938											
AGBL5	60509	broad.mit.edu	37	chr2	27278818	27278818	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaagcctggaaacaaacaGagccagcagaacagaagctc	17	3	10	11	0	0	4	0	1	0	3	1	5	0	5	2	1	7	2	2	1	5	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:27278818G>A	uc002rie.2	+	7	1394	c.1177G>A	c.(1177-1179)GAG>AAG	p.E393K	AGBL5_uc002ric.2_Missense_Mutation_p.E393K|AGBL5_uc002rid.2_Missense_Mutation_p.E393K|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	393					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAAACAAACAGAGCCAGCAGA	0.522													27	118					0	0	0	0	A	27278818	A	A	27278818	3	1	93	1	0	0	0	0	1	0	0	0	378	943	33	2	1199	2	AGBL5	2	27278818	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08		27278818	215920555	24	17939											
PPM1G	5496	broad.mit.edu	37	chr2	27609064	27609064	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgtaagcagacagaccttCtgtagcttgccttccttgta	8	13	10	10	0	1	2	0	0	1	2	2	2	2	2	3	1	3	5	3	1	3	7			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:27609064C>T	uc002rkl.2	-	4	380	c.273G>A	c.(271-273)CAG>CAA	p.Q91Q	PPM1G_uc002rkm.2_5'UTR	NM_002707	NP_002698	O15355	PPM1G_HUMAN	protein phosphatase 1G	91					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GACAGACCTTCTGTAGCTTGC	0.473													65	232					0	0	0	0	T	27609064	T	T	27609064	2	4	93	1	0	0	0	0	0	0	0	1	12400	912	32	2		2	PPM1G	2	27609064	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	330246	27609064	215590309	25	17940											
IFT172	26160	broad.mit.edu	37	chr2	27680753	27680753	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgaggagatctggatggtgCttccctaccaggcggatcat	8	10	13	10	1	2	2	1	1	1	1	3	5	3	4	2	5	2	1	2	5	1	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:27680753C>T	uc002rku.2	-	28	3117	c.3066G>A	c.(3064-3066)AAG>AAA	p.K1022K		NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1022					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					CTGGATGGTGCTTCCCTACCA	0.522													22	58					0	0	0	0	T	27680753	T	T	27680753	2	4	93	1	0	0	0	0	0	0	0	1	7596	796	28	4		4	IFT172	2	27680753	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	71689	27680753	215518620	26	17941											
PSME4	23198	broad.mit.edu	37	chr2	54112830	54112830	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcagcaaaaccttaccttGaaaaacaaaggtagaagctg	17	9	7	8	0	1	2	1	1	0	1	1	2	1	2	2	1	5	3	2	1	8	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:54112830G>A	uc002rxp.2	-	41	4868	c.4812C>T	c.(4810-4812)TTC>TTT	p.F1604F	PSME4_uc010yop.1_Silent_p.F1490F|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Silent_p.F979F|PSME4_uc010fbv.1_Silent_p.F748F|PSME4_uc010fbt.1_Silent_p.F91F	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1604					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ACCTTACCTTGAAAAACAAAG	0.363													9	34					0	0	0	0	A	54112830	A	A	54112830	2	1	93	1	0	0	0	0	0	0	0	1	12771	1281	45	2		2	PSME4	2	54112830	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	26432077	54112830	189086543	27	17942											
ACTR2	10097	broad.mit.edu	37	chr2	65492283	65492283	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agctttacttagaacgagttTtgaagggtgatgtggaaaaa	14	12	12	3	1	0	3	0	2	0	1	0	5	0	4	0	2	3	2	0	2	6	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:65492283T>C	uc002sdq.2	+	8	1203	c.988T>C	c.(988-990)TTG>CTG	p.L330L	ACTR2_uc010yqf.1_Silent_p.L275L|ACTR2_uc002sdp.2_Silent_p.L335L|ACTR2_uc010yqg.1_Silent_p.L278L	NM_005722	NP_005713	P61160	ARP2_HUMAN	actin-related protein 2 isoform b	330					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding				0						AGAACGAGTTTTGAAGGGTGA	0.368													43	122					0	0	0	0	C	65492283	C	C	65492283	2	2	93	1	0	0	0	0	0	0	0	1	211	1838	64	5		5	ACTR2	2	65492283	Silent	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	11379453	65492283	177707090	28	17943											
ARHGAP25	9938	broad.mit.edu	37	chr2	69002483	69002483	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccatcgtgaagaactggcaGcagaggtactttgtgctgag	10	10	13	8	1	0	4	0	2	0	2	2	4	1	4	1	2	4	4	1	2	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:69002483G>A	uc002seu.2	+	2	556	c.192G>A	c.(190-192)CAG>CAA	p.Q64Q	ARHGAP25_uc010yqk.1_Silent_p.Q38Q|ARHGAP25_uc010fdg.2_Silent_p.Q64Q|ARHGAP25_uc010yql.1_Silent_p.Q64Q|ARHGAP25_uc002sev.2_Silent_p.Q57Q|ARHGAP25_uc002sew.2_Silent_p.Q57Q|ARHGAP25_uc002sex.2_Silent_p.Q57Q|ARHGAP25_uc010fdh.1_RNA	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	64	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						AGAACTGGCAGCAGAGGTACT	0.567													4	226					0	0	0	0	A	69002483	A	A	69002483	2	1	93	1	0	0	0	0	0	0	0	1	874	962	34	4		4	ARHGAP25	2	69002483	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3510200	69002483	174196890	29	17944											
ATP6V1B1	525	broad.mit.edu	37	chr2	71186202	71186202	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggggccagtggtcatggCggaggactttctggatatca	9	9	15	8	1	3	0	2	0	1	0	3	3	3	3	1	7	0	0	1	7	2	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:71186202C>T	uc002shj.2	+	5	509	c.422C>T	c.(421-423)GCG>GTG	p.A141V	ATP6V1B1_uc002shi.1_Missense_Mutation_p.A141V|ATP6V1B1_uc010fdv.2_Missense_Mutation_p.A141V|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.A99V	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	141					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						GTGGTCATGGCGGAGGACTTT	0.582													5	55					0	0	0	0	T	71186202	T	T	71186202	3	4	93	1	0	0	0	0	1	0	0	0	1180	768	27	1	440	1	ATP6V1B1	2	71186202	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	2183719	71186202	172013171	30	17945											
MRPL53	116540	broad.mit.edu	37	chr2	74699368	74699368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgccgcgcataatcaggcGatgcccgtctcctggggaag	8	6	14	13	5	2	0	1	0	1	0	3	2	2	1	3	3	2	1	3	3	2	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:74699368G>A	uc002sln.2	-	3	357	c.217C>T	c.(217-219)CGC>TGC	p.R73C	CCDC142_uc002slo.2_RNA	NM_053050	NP_444278	Q96EL3	RM53_HUMAN	mitochondrial ribosomal protein L53 precursor	73						mitochondrion|ribosome					0						ATAATCAGGCGATGCCCGTCT	0.682													11	36					0	0	0	0	A	74699368	A	A	74699368	3	1	93	1	0	0	0	0	1	0	0	0	9870	1058	37	1	125	1	MRPL53	2	74699368	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3513166	74699368	168500005	31	17946											
C2orf29	55571	broad.mit.edu	37	chr2	101881353	101881353	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaccgcctccactccacatTtgtgaggatgaacttgcttg	8	11	8	14	1	0	2	0	2	0	0	2	3	2	3	5	1	2	1	5	1	1	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:101881353T>C	uc002taw.3	+	4	961	c.879T>C	c.(877-879)ATT>ATC	p.I293I		NM_017546	NP_060016	Q9UKZ1	CB029_HUMAN	hypothetical protein LOC55571	293					cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol				ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CACTCCACATTTGTGAGGATG	0.488													15	74					0	0	0	0	C	101881353	C	C	101881353	2	2	93	1	0	0	0	0	0	0	0	1	2171	1829	64	5		5	C2orf29	2	101881353	Silent	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	27181985	101881353	141318020	32	17947											
MYO7B	4648	broad.mit.edu	37	chr2	128384562	128384562	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccctcaggccccatacactCagaagcaagtcacaccactg	12	5	6	18	0	3	1	3	0	0	1	3	1	3	1	5	1	2	1	5	1	3	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:128384562C>G	uc002top.2	+	31	4203	c.4150C>G	c.(4150-4152)CAG>GAG	p.Q1384E	MYO7B_uc002toq.1_Missense_Mutation_p.Q237E|MYO7B_uc002tor.1_Missense_Mutation_p.Q237E	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1384	FERM 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CCCATACACTCAGAAGCAAGT	0.597													6	15					0	0	0	0	G	128384562	G	G	128384562	3	3	93	1	0	0	0	0	1	0	0	0	10136	827	29	2	4268	2	MYO7B	2	128384562	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	26503209	128384562	114814811	33	17948											
TANC1	85461	broad.mit.edu	37	chr2	160019983	160019983	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgcccaaagcagaatcctCagctggagatggtccagtcc	10	7	11	13	0	1	2	1	0	0	2	4	3	4	2	4	2	3	3	4	2	2	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:160019983C>G	uc002uag.2	+	8	1146	c.872C>G	c.(871-873)TCA>TGA	p.S291*	TANC1_uc010fol.1_Nonsense_Mutation_p.S185*|TANC1_uc010zcm.1_Nonsense_Mutation_p.S290*|TANC1_uc010fom.1_Intron	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	291						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						GCAGAATCCTCAGCTGGAGAT	0.572													19	51					0	0	0	0	G	160019983	G	G	160019983	4	3	93	1	0	0	0	0	0	1	0	0	15610	838	29	2	894	2	TANC1	2	160019983	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	31635421	160019983	83179390	34	17949											
PPIG	9360	broad.mit.edu	37	chr2	170493609	170493609	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agagagaagaacaccaccagGaagatcaagaagtaaagata	22	3	10	6	0	1	6	1	0	0	6	1	8	1	7	2	1	1	1	2	1	8	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:170493609G>A	uc002uez.2	+	14	2061	c.1841G>A	c.(1840-1842)GGA>GAA	p.G614E	PPIG_uc010fpx.2_Missense_Mutation_p.G599E|PPIG_uc010fpy.2_Missense_Mutation_p.G607E|PPIG_uc002ufb.2_Missense_Mutation_p.G614E|PPIG_uc002ufd.2_Missense_Mutation_p.G611E	NM_004792	NP_004783	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G	614	Arg/Ser-rich (RS domain).				protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|central_nervous_system(1)	3					L-Proline(DB00172)	ACACCACCAGGAAGATCAAGA	0.463													6	30					0	0	0	0	A	170493609	A	A	170493609	3	1	93	1	0	0	0	0	1	0	0	0	12384	1174	41	2	1887	2	PPIG	2	170493609	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	10473626	170493609	72705764	35	17950											
PPIG	9360	broad.mit.edu	37	chr2	170493718	170493718	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacagaaaccaagagagtaaGagctcacacagaaaagaaaa	23	3	8	7	0	1	5	1	0	0	5	1	6	1	5	1	0	3	2	1	0	8	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:170493718G>C	uc002uez.2	+	14	2170	c.1950G>C	c.(1948-1950)AAG>AAC	p.K650N	PPIG_uc010fpx.2_Missense_Mutation_p.K635N|PPIG_uc010fpy.2_Missense_Mutation_p.K643N|PPIG_uc002ufb.2_Missense_Mutation_p.K650N|PPIG_uc002ufd.2_Missense_Mutation_p.K647N	NM_004792	NP_004783	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G	650					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|central_nervous_system(1)	3					L-Proline(DB00172)	AAGAGAGTAAGAGCTCACACA	0.388													10	63					0	0	0	0	C	170493718	C	C	170493718	3	2	93	1	0	0	0	0	1	0	0	0	12384	933	33	2	1996	2	PPIG	2	170493718	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	109	170493718	72705655	36	17951											
KLHL23	151230	broad.mit.edu	37	chr2	170592202	170592202	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tataatctactgagctatatCaacattgatatagatccagt	15	14	5	7	0	2	3	1	2	1	1	3	3	3	3	1	0	3	1	1	0	8	8			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:170592202C>G	uc002ufh.1	+	4	1016	c.678C>G	c.(676-678)ATC>ATG	p.I226M	KLHL23_uc002ufi.1_Missense_Mutation_p.I226M	NM_144711	NP_653312	Q8NBE8	KLH23_HUMAN	kelch-like 23	226	BACK.										0						TGAGCTATATCAACATTGATA	0.388													9	38					0	0	0	0	G	170592202	G	G	170592202	3	3	93	1	0	0	0	0	1	0	0	0	8417	816	29	2	680	2	KLHL23	2	170592202	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	98484	170592202	72607171	37	17952											
UBR3	130507	broad.mit.edu	37	chr2	170897435	170897435	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaggttccaattctttatCatgatgtaacatcccttttg	9	17	6	9	0	2	2	1	2	1	0	4	2	4	2	2	1	1	2	2	1	3	7			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:170897435C>T	uc010zdi.1	+	32	4600	c.4600C>T	c.(4600-4602)CAT>TAT	p.H1534Y	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_Missense_Mutation_p.H355Y|UBR3_uc002uft.3_Missense_Mutation_p.H391Y|UBR3_uc010zdj.1_Missense_Mutation_p.H225Y|UBR3_uc002ufu.3_Missense_Mutation_p.H40Y	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1534					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0						AATTCTTTATCATGATGTAAC	0.328													22	46					0	0	0	0	T	170897435	T	T	170897435	3	4	93	1	0	0	0	0	1	0	0	0	16971	826	29	2	4726	2	UBR3	2	170897435	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	305233	170897435	72301938	38	17953											
TTN	7273	broad.mit.edu	37	chr2	179412921	179412921	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcaagcaggtagccagtgatCcggctgcctccatcgtggtc	7	9	12	13	2	1	1	1	1	0	0	5	1	3	1	4	3	3	3	4	3	2	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:179412921C>T	uc010zfg.1	-	288	85952	c.85728G>A	c.(85726-85728)CGG>CGA	p.R28576R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.R22271R|TTN_uc010zfi.1_Silent_p.R22204R|TTN_uc010zfj.1_Silent_p.R22079R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29503							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCAGTGATCCGGCTGCCTC	0.493													75	201					0	0	0	0	T	179412921	T	T	179412921	2	4	93	1	0	0	0	0	0	0	0	1	16803	842	30	2		2	TTN	2	179412921	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	8515486	179412921	63786452	39	17954											
TTN	7273	broad.mit.edu	37	chr2	179599162	179599166	+	Frame_Shift_Del	DEL	ACAAG	-	-																															acgaaaagatctccagacacAcaagagacttctgagaaaac																										TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:179599162_179599166delACAAG	uc010zfg.1	-	49	11877_11881	c.11653_11657delCTTGT	c.(11653-11658)CTTGTGfs	p.L3885fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.L546fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4812_4813							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCAGACACACAAGAGACTTCTGA	0.395													---	---	---								-	179599166	-	-	179599162	7	5	93	1	0	1	0	1	0	0	0	0	16803	159	6	0	89384	0	TTN	2	179599162	Frame_Shift_Del	DEL	ACAAG	TCGA-CQ-5326-01A-01D-1870-08	186241	179599162	63600211	40	17955											
ITGA4	3676	broad.mit.edu	37	chr2	182322416	182322416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggcgcgaacccggcccccGaagggccgccgtccgggaga	7	1	17	16	7	0	1	0	0	0	1	1	5	1	1	6	4	1	0	6	4	2	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:182322416G>A	uc002unu.2	+	1	798	c.35G>A	c.(34-36)CGA>CAA	p.R12Q	ITGA4_uc002unt.2_Missense_Mutation_p.R12Q|ITGA4_uc010zfl.1_Missense_Mutation_p.R12Q	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	12					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CCCGGCCCCCGAAGGGCCGCC	0.662													7	17					0	0	0	0	A	182322416	A	A	182322416	3	1	93	1	0	0	0	0	1	0	0	0	7917	1058	37	1	37	1	ITGA4	2	182322416	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	2723254	182322416	60876957	41	17956											
GLS	2744	broad.mit.edu	37	chr2	191745874	191745874	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcggtcgcccgccggcgtgAgcgcgactctgcggcgggca	3	5	18	15	9	1	1	0	1	1	0	2	2	1	1	2	4	3	1	2	4	0	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:191745874A>C	uc002usf.2	+	1	328	c.64A>C	c.(64-66)AGC>CGC	p.S22R	GLS_uc002usd.2_Missense_Mutation_p.S22R|GLS_uc002use.2_Missense_Mutation_p.S22R	NM_014905	NP_055720	O94925	GLSK_HUMAN	glutaminase precursor	22					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			ovary(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CGCCGGCGTGAGCGCGACTCT	0.592													3	9					0	0	0	0	C	191745874	C	C	191745874	3	2	93	1	0	0	0	0	1	0	0	0	6500	304	11	5	66	5	GLS	2	191745874	Missense_Mutation	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	9423458	191745874	51453499	42	17957											
STAT1	6772	broad.mit.edu	37	chr2	191845388	191845388	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgagaccatcggggctggcGttaggacctaaacaaataaa	15	7	11	8	2	0	1	0	1	0	1	1	3	0	2	2	4	1	2	2	4	6	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:191845388G>A	uc002usj.2	-	19	1978	c.1590C>T	c.(1588-1590)AAC>AAT	p.N530N	STAT1_uc010fse.1_Silent_p.N530N|STAT1_uc002usk.2_Silent_p.N530N|STAT1_uc002usl.2_Silent_p.N532N|STAT1_uc010fsf.1_Silent_p.N342N	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	530					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	CGGGGCTGGCGTTAGGACCTA	0.433													15	43					0	0	0	0	A	191845388	A	A	191845388	2	1	93	1	0	0	0	0	0	0	0	1	15330	1136	40	1		1	STAT1	2	191845388	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	99514	191845388	51353985	43	17958											
DNAH7	56171	broad.mit.edu	37	chr2	196801362	196801362	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatagtatctcaagaagtTcatcattggacaaaaaaaag	19	9	7	6	0	3	2	3	0	1	2	4	3	3	3	0	1	0	2	0	1	8	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:196801362T>C	uc002utj.3	-	20	3334	c.3233A>G	c.(3232-3234)GAA>GGA	p.E1078G		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1078	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CTCAAGAAGTTCATCATTGGA	0.299													20	92					0	0	0	0	C	196801362	C	C	196801362	3	2	93	1	0	0	0	0	1	0	0	0	4628	1783	62	5	9025	5	DNAH7	2	196801362	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	4955974	196801362	46398011	44	17959											
NIF3L1	60491	broad.mit.edu	37	chr2	201757020	201757020	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtgatccgggctctggaGaacagagtcggtatctactc	8	10	13	10	2	2	3	0	1	2	2	5	4	3	3	1	4	2	2	1	4	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:201757020G>A	uc002uwm.2	+	2	445	c.354G>A	c.(352-354)GAG>GAA	p.E118E	NIF3L1_uc002uwl.2_Silent_p.E91E|NIF3L1_uc002uwn.2_Silent_p.E91E|NIF3L1_uc002uwo.2_Silent_p.E118E|NIF3L1_uc002uwp.2_Silent_p.E118E|NIF3L1_uc002uwq.2_Silent_p.E118E	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	118					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						GGGCTCTGGAGAACAGAGTCG	0.547													22	88					0	0	0	0	A	201757020	A	A	201757020	2	1	93	1	0	0	0	0	0	0	0	1	10470	933	33	2		2	NIF3L1	2	201757020	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	4955658	201757020	41442353	45	17960											
LANCL1	10314	broad.mit.edu	37	chr2	211319997	211319997	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	taactgtaggtaggcagggtCcccaaatacatcataaagat	15	9	9	8	0	1	1	1	0	0	1	2	1	2	1	2	3	2	3	2	3	7	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:211319997C>T	uc010zjh.1	-	4	316	c.241G>A	c.(241-243)GAC>AAC	p.D81N	LANCL1_uc002ved.2_Missense_Mutation_p.D81N|LANCL1_uc010fuq.2_Missense_Mutation_p.D81N	NM_001136574	NP_001130046	O43813	LANC1_HUMAN	lanthionine synthetase C-like protein 1	81						cytoplasm|integral to plasma membrane|microtubule cytoskeleton|nucleus	catalytic activity|G-protein coupled receptor activity|glutathione binding|low-density lipoprotein particle receptor binding|SH3 domain binding|zinc ion binding				0				Epithelial(149;0.00562)|Lung(261;0.0468)|LUSC - Lung squamous cell carcinoma(261;0.0495)|all cancers(144;0.0569)		TAGGCAGGGTCCCCAAATACA	0.403													18	47					0	0	0	0	T	211319997	T	T	211319997	3	4	93	1	0	0	0	0	1	0	0	0	8660	855	30	2	986	2	LANCL1	2	211319997	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	9562977	211319997	31879376	46	17961											
PTPRN	5798	broad.mit.edu	37	chr2	220167381	220167381	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgggggcagcagcaggtgctCcaagagaggcgggagcagct	9	4	19	9	1	0	1	0	0	0	1	1	3	1	2	1	5	5	6	1	5	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr2:220167381C>G	uc002vkz.2	-	5	645	c.556G>C	c.(556-558)GAG>CAG	p.E186Q	PTPRN_uc010zlc.1_Missense_Mutation_p.E96Q|PTPRN_uc002vla.2_Missense_Mutation_p.E186Q	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	186	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		AGCAGGTGCTCCAAGAGAGGC	0.627													11	41					0	0	0	0	G	220167381	G	G	220167381	3	3	93	1	0	0	0	0	1	0	0	0	12872	864	30	2	2459	2	PTPRN	2	220167381	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	8847384	220167381	23031992	47	17962											
NT5DC2	64943	broad.mit.edu	37	chr3	52561343	52561343	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcccttttccaagcgggtGatccggtcccactgaagtga	7	11	11	12	2	0	3	0	3	0	0	3	3	3	3	4	2	2	0	4	2	2	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr3:52561343G>C	uc003deo.2	-	10	1399	c.975C>G	c.(973-975)ATC>ATG	p.I325M	NT5DC2_uc003dem.2_Missense_Mutation_p.I195M|NT5DC2_uc003den.2_Missense_Mutation_p.I362M|NT5DC2_uc010hmi.2_Missense_Mutation_p.I337M|NT5DC2_uc010hmj.2_Missense_Mutation_p.I141M	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	325							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		CCAAGCGGGTGATCCGGTCCC	0.612													25	37					0	0	0	0	C	52561343	C	C	52561343	3	2	93	1	0	0	0	0	1	0	0	0	10745	1280	45	2	607	2	NT5DC2	3	52561343	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08		52561343	145461087	48	17963											
PBRM1	55193	broad.mit.edu	37	chr3	52675991	52675991	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctaaagcagcatcttcttCactttctgagccatattgaa	12	13	6	10	0	4	2	1	2	3	0	4	2	4	2	1	0	4	3	1	0	4	6			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr3:52675991C>A	uc003des.2	-	10	1078	c.1066G>T	c.(1066-1068)GAA>TAA	p.E356*	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Nonsense_Mutation_p.E356*|PBRM1_uc003der.2_Nonsense_Mutation_p.E324*|PBRM1_uc003det.2_Nonsense_Mutation_p.E356*|PBRM1_uc003deu.2_Nonsense_Mutation_p.E356*|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Nonsense_Mutation_p.E356*|PBRM1_uc010hmk.1_Nonsense_Mutation_p.E356*|PBRM1_uc003dey.2_Nonsense_Mutation_p.E356*|PBRM1_uc003dez.1_Nonsense_Mutation_p.E356*|PBRM1_uc003dfb.1_Nonsense_Mutation_p.E254*	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	356					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GCATCTTCTTCACTTTCTGAG	0.368			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								78	177					1.02218e-41	1.1481e-41	1	0	A	52675991	A	A	52675991	4	1	93	1	0	0	0	0	0	1	0	0	11545	835	29	2	3918	2	PBRM1	3	52675991	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	114648	52675991	145346439	49	17964											
TMEM45A	55076	broad.mit.edu	37	chr3	100277257	100277257	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttccccatcagcctttatcTtctacaaccacactcatggc	9	13	3	16	0	4	0	2	0	2	0	5	0	5	0	4	1	3	0	4	1	3	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr3:100277257T>G	uc003dtz.1	+	4	725	c.412T>G	c.(412-414)TTC>GTC	p.F138V	TMEM45A_uc003dua.1_Missense_Mutation_p.F154V	NM_018004	NP_060474	Q9NWC5	TM45A_HUMAN	transmembrane protein 45A	138						integral to membrane				skin(2)|ovary(1)	3						AGCCTTTATCTTCTACAACCA	0.478													36	98					0	0	0	0	G	100277257	G	G	100277257	3	3	93	1	0	0	0	0	1	0	0	0	16235	1609	56	5	422	5	TMEM45A	3	100277257	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	47601266	100277257	97745173	50	17965											
KIAA2018	205717	broad.mit.edu	37	chr3	113377167	113377168	+	Frame_Shift_Ins	INS	-	A	A																															tacaaaggtacagctgtcacINSatgtattagttgttgcattg																										TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr3:113377167_113377168insA	uc003eam.2	-	7	3772_3773	c.3361_3362insT	c.(3361-3363)TGTfs	p.C1121fs	KIAA2018_uc003eal.2_Frame_Shift_Ins_p.C1065fs	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1121					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						ACAGCTGTCACATGTATTAGTT	0.455													---	---	---								A	113377168	A	A	113377167	7	5	93	1	0	1	1	0	0	0	0	0	8307	478	17	0	3379	0	KIAA2018	3	113377167	Frame_Shift_Ins	INS	-	TCGA-CQ-5326-01A-01D-1870-08	13099910	113377167	84645263	51	17966											
SLC15A2	6565	broad.mit.edu	37	chr3	121641670	121641670	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttctggagacattccaaagCgacagcactggctagactgg	11	8	12	10	1	1	2	0	0	1	2	2	4	2	2	1	3	2	3	1	3	2	3	rs145317059	byFrequency	TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr3:121641670C>T	uc003eep.2	+	9	982	c.829C>T	c.(829-831)CGA>TGA	p.R277*	SLC15A2_uc011bjn.1_Nonsense_Mutation_p.R246*	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	277					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CATTCCAAAGCGACAGCACTG	0.428													21	36					0	0	0	0	T	121641670	T	T	121641670	4	4	93	1	0	0	0	0	0	1	0	0	14464	760	27	1	863	1	SLC15A2	3	121641670	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	8264503	121641670	76380760	52	17967											
ACPP	55	broad.mit.edu	37	chr3	132086633	132086633	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccacattcgccgtggactCtgctggcagagagaatccta	10	9	10	12	2	1	2	0	0	1	2	4	4	3	3	3	2	1	2	3	2	2	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr3:132086633C>G	uc003eop.3	+	11	1314	c.1224C>G	c.(1222-1224)CTC>CTG	p.L408L		NM_001134194	NP_001127666	P15309	PPAP_HUMAN	acid phosphatase, prostate long isoform	Error:Variant_position_missing_in_P15309_after_alignment						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						GCCGTGGACTCTGCTGGCAGA	0.483													7	323					0	0	0	0	G	132086633	G	G	132086633	2	3	93	1	0	0	0	0	0	0	0	1	167	900	32	2		2	ACPP	3	132086633	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	10444963	132086633	65935797	53	17968											
PPP2R3A	5523	broad.mit.edu	37	chr3	135720782	135720782	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagggaaggaaagttaagTctgactcatttaataggagg	16	9	13	3	0	2	1	1	1	1	0	2	5	2	4	0	4	0	1	0	4	6	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr3:135720782T>C	uc003eqv.1	+	2	1007	c.442T>C	c.(442-444)TCT>CCT	p.S148P	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	148					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						GAAAGTTAAGTCTGACTCATT	0.403													30	66					0	0	0	0	C	135720782	C	C	135720782	3	2	93	1	0	0	0	0	1	0	0	0	12448	1667	58	5	444	5	PPP2R3A	3	135720782	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	3634149	135720782	62301648	54	17969											
ZIC1	7545	broad.mit.edu	37	chr3	147128485	147128485	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgctgcgccgcagctgcacGgctacgggcccatgaacgtg	7	6	14	14	5	0	1	0	1	0	0	0	1	0	1	2	2	6	5	2	2	2	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr3:147128485G>A	uc003ewe.2	+	1	1305	c.586G>A	c.(586-588)GGC>AGC	p.G196S		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	196					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GCAGCTGCACGGCTACGGGCC	0.652													14	44					0	0	0	0	A	147128485	A	A	147128485	3	1	93	1	0	0	0	0	1	0	0	0	17745	1116	39	1	588	1	ZIC1	3	147128485	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	11407703	147128485	50893945	55	17970											
KLHL6	89857	broad.mit.edu	37	chr3	183209891	183209891	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcttctcgtcccgcccgcCggtgatgtagagccggttgt	3	12	13	13	5	2	2	0	1	2	1	4	2	3	2	4	2	1	3	4	2	1	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr3:183209891C>T	uc003flr.2	-	7	1748	c.1690G>A	c.(1690-1692)GGC>AGC	p.G564S	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_3'UTR|KLHL6_uc010hxk.1_RNA	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	564	Kelch 6.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			TCCCGCCCGCCGGTGATGTAG	0.672													30	78					0	0	0	0	T	183209891	T	T	183209891	3	4	93	1	0	0	0	0	1	0	0	0	8432	652	23	1	179	1	KLHL6	3	183209891	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	36081406	183209891	14812539	56	17971											
EHHADH	1962	broad.mit.edu	37	chr3	184910588	184910588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagaccttgcccctttctaGatttccagcccacatccaac	10	11	4	16	0	1	2	0	0	1	2	3	2	3	2	6	0	3	0	6	0	3	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr3:184910588G>A	uc003fpf.2	-	7	1625	c.1598C>T	c.(1597-1599)TCT>TTT	p.S533F	EHHADH_uc011brs.1_Missense_Mutation_p.S437F	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	533	3-hydroxyacyl-CoA dehydrogenase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	CCCCTTTCTAGATTTCCAGCC	0.483													23	63					0	0	0	0	A	184910588	A	A	184910588	3	1	93	1	0	0	0	0	1	0	0	0	5004	942	33	2	577	2	EHHADH	3	184910588	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1700697	184910588	13111842	57	17972											
HTT	3064	broad.mit.edu	37	chr4	3219628	3219628	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctaaggaacatcatcatCagcctggcccgcctgcccct	8	9	8	16	1	3	0	3	0	0	0	3	1	3	1	5	2	4	1	5	2	2	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr4:3219628C>T	uc011bvq.1	+	53	7342	c.7197C>T	c.(7195-7197)ATC>ATT	p.I2399I		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2397	Nuclear export signal (By similarity).				establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		ACATCATCATCAGCCTGGCCC	0.567													20	54					0	0	0	0	T	3219628	T	T	3219628	2	4	93	1	0	0	0	0	0	0	0	1	7496	816	29	2		2	HTT	4	3219628	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		3219628	187934648	58	17973											
CCDC158	339965	broad.mit.edu	37	chr4	77283442	77283442	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggcctcaagctcccggatCtttgcatcttttttatcttt	5	18	6	12	1	4	0	1	0	3	0	5	1	5	1	2	2	2	2	2	2	2	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr4:77283442C>G	uc003hkb.3	-	12	2010	c.1857G>C	c.(1855-1857)AAG>AAC	p.K619N		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	619	Potential.									skin(3)|ovary(2)|pancreas(1)	6						GCTCCCGGATCTTTGCATCTT	0.393													30	143					0	0	0	0	G	77283442	G	G	77283442	3	3	93	1	0	0	0	0	1	0	0	0	2803	912	32	2	1536	2	CCDC158	4	77283442	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	74063814	77283442	113870834	59	17974											
NKX6-1	4825	broad.mit.edu	37	chr4	85414577	85414577	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggcttattgtagtcgtcGtcctcttcctcgttctccga	5	15	9	12	4	2	1	0	0	2	1	8	2	4	1	3	1	0	3	3	1	2	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr4:85414577G>A	uc003hpa.1	-	3	975	c.969C>T	c.(967-969)GAC>GAT	p.D323D		NM_006168	NP_006159	P78426	NKX61_HUMAN	NK6 transcription factor related, locus 1	323	Involved in DNA-binding (By similarity).				detection of glucose|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|type B pancreatic cell maturation	nucleus					0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.0013)		TGTAGTCGTCGTCCTCTTCCT	0.612													29	80					0	0	0	0	A	85414577	A	A	85414577	2	1	93	1	0	0	0	0	0	0	0	1	10511	1136	40	1		1	NKX6-1	4	85414577	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	8131135	85414577	105739699	60	17975											
PDE5A	8654	broad.mit.edu	37	chr4	120481508	120481508	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actccatgtgaaacacactaGaaaaagaatcctaaaaacag	21	6	5	9	0	0	3	0	1	0	2	2	3	2	3	2	0	2	0	2	0	8	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr4:120481508G>C	uc003idh.2	-	7	1297	c.1142C>G	c.(1141-1143)TCT>TGT	p.S381C	PDE5A_uc003idf.2_Missense_Mutation_p.S339C|PDE5A_uc003idg.2_Missense_Mutation_p.S329C	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	381	GAF 2.			S -> F (in Ref. 9; AAP31235).	platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	AAACACACTAGAAAAAGAATC	0.323													7	42					0	0	0	0	C	120481508	C	C	120481508	3	2	93	1	0	0	0	0	1	0	0	0	11698	942	33	2	1545	2	PDE5A	4	120481508	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	35066931	120481508	70672768	61	17976											
CDH18	1016	broad.mit.edu	37	chr5	19571716	19571716	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgttagtactgtcaggatCttgtgccaaaactgtaccaa	11	12	9	9	0	2	0	1	0	1	0	2	1	2	1	2	1	4	4	2	1	6	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr5:19571716C>G	uc003jgc.2	-	7	1602	c.1225G>C	c.(1225-1227)GAT>CAT	p.D409H	CDH18_uc003jgd.2_Missense_Mutation_p.D409H|CDH18_uc011cnm.1_Missense_Mutation_p.D409H	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	409	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTGTCAGGATCTTGTGCCAAA	0.393													23	69					0	0	0	0	G	19571716	G	G	19571716	3	3	93	1	0	0	0	0	1	0	0	0	3118	913	32	2	1171	2	CDH18	5	19571716	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		19571716	161343544	62	17977											
C9	735	broad.mit.edu	37	chr5	39341263	39341263	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacacccatagcctgctgttCgtgccagctcagactcttct	7	11	7	16	1	3	1	1	0	2	1	4	1	3	1	3	0	4	3	3	0	1	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr5:39341263C>T	uc003jlv.3	-	4	550	c.461G>A	c.(460-462)CGA>CAA	p.R154Q		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	154	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			GCCTGCTGTTCGTGCCAGCTC	0.458													40	90					0	0	0	0	T	39341263	T	T	39341263	3	4	93	1	0	0	0	0	1	0	0	0	2455	884	31	1	1250	1	C9	5	39341263	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	19769547	39341263	141573997	63	17978											
C6	729	broad.mit.edu	37	chr5	41158799	41158799	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gataaatccattttctggagGaactggctgaggacacccgg	11	9	12	9	1	1	1	0	1	1	0	2	5	2	4	2	5	1	1	2	5	3	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr5:41158799G>A	uc003jmk.2	-	13	2155	c.1945C>T	c.(1945-1947)CCT>TCT	p.P649S	C6_uc003jml.1_Missense_Mutation_p.P649S	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	649	Sushi 1.|C5b-binding domain.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTTTCTGGAGGAACTGGCTGA	0.398													10	64					0	0	0	0	A	41158799	A	A	41158799	3	1	93	1	0	0	0	0	1	0	0	0	2325	1174	41	2	883	2	C6	5	41158799	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1817536	41158799	139756461	64	17979											
IL6ST	3572	broad.mit.edu	37	chr5	55253084	55253084	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttgagtatgggatggatCtattttataccagaaacttg	11	14	10	6	0	1	2	0	1	1	1	1	4	1	4	2	2	2	1	2	2	5	7			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr5:55253084C>G	uc003jqq.2	-	9	1264	c.1009G>C	c.(1009-1011)GAT>CAT	p.D337H	IL6ST_uc010iwb.2_Missense_Mutation_p.D337H|IL6ST_uc010iwc.2_Intron|IL6ST_uc010iwd.2_Intron|IL6ST_uc011cqk.1_Missense_Mutation_p.D48H|IL6ST_uc003jqr.2_Intron	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	337	Extracellular (Potential).|Fibronectin type-III 3.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				TGGGATGGATCTATTTTATAC	0.274			O		hepatocellular ca								13	112					0	0	0	0	G	55253084	G	G	55253084	3	3	93	1	0	0	0	0	1	0	0	0	7742	913	32	2	1783	2	IL6ST	5	55253084	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	14094285	55253084	125662176	65	17980											
RASGRF2	5924	broad.mit.edu	37	chr5	80408598	80408598	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacctttctgcacacctatCgtattttcactactgccgct	8	14	4	15	2	2	0	1	0	1	0	3	0	2	0	3	0	3	3	3	0	3	6			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr5:80408598C>A	uc003kha.1	+	14	2008	c.2008C>A	c.(2008-2010)CGT>AGT	p.R670S	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	670	N-terminal Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		GCACACCTATCGTATTTTCAC	0.507													4	200					0.000602214	0.000622288	1	0	A	80408598	A	A	80408598	3	1	93	1	0	0	0	0	1	0	0	0	13138	884	31	3	2062	3	RASGRF2	5	80408598	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	25155514	80408598	100506662	66	17981											
PCDHGA7	56108	broad.mit.edu	37	chr5	140764430	140764430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacggtcagcctcctctgtCagccaccgtcacactcaccg	7	7	7	20	3	5	0	4	0	1	0	6	0	6	0	6	1	2	0	6	1	0	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr5:140764430C>T	uc003lka.1	+	1	1964	c.1964C>T	c.(1963-1965)TCA>TTA	p.S655L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.S655L	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	655	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCCTCTGTCAGCCACCGTC	0.652													12	29					0	0	0	0	T	140764430	T	T	140764430	3	4	93	1	0	0	0	0	1	0	0	0	11613	838	29	2	1966	2	PCDHGA7	5	140764430	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	60355832	140764430	40150830	67	17982											
FAT2	2196	broad.mit.edu	37	chr5	150947251	150947251	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgagctttgtggtggtgatCaacccagttcgagcattaag	10	12	12	7	1	1	2	1	2	0	0	2	3	1	2	1	2	3	3	1	2	2	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr5:150947251C>G	uc003lue.3	-	1	1255	c.1242G>C	c.(1240-1242)TTG>TTC	p.L414F	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.L414F	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	414	Extracellular (Potential).|Cadherin 3.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGTGGTGATCAACCCAGTTC	0.512													20	106					0	0	0	0	G	150947251	G	G	150947251	3	3	93	1	0	0	0	0	1	0	0	0	5722	825	29	2	11899	2	FAT2	5	150947251	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	10182821	150947251	29968009	68	17983											
CPEB4	80315	broad.mit.edu	37	chr5	173359491	173359491	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccaggatccgatagctctCtgcttattaatggtaagtga	11	13	9	8	1	1	1	0	1	1	0	4	3	3	2	2	2	2	3	2	2	4	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr5:173359491C>T	uc003mcs.3	+	3	2652	c.1246C>T	c.(1246-1248)CTG>TTG	p.L416L	CPEB4_uc010jju.1_Intron|CPEB4_uc010jjv.2_Intron|CPEB4_uc011dfg.1_Intron|CPEB4_uc003mct.3_Silent_p.L34L|CPEB4_uc003mcu.3_Intron	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	416							nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CGATAGCTCTCTGCTTATTAA	0.353													20	63					0	0	0	0	T	173359491	T	T	173359491	2	4	93	1	0	0	0	0	0	0	0	1	3818	912	32	2		2	CPEB4	5	173359491	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	22412240	173359491	7555769	69	17984											
SQSTM1	8878	broad.mit.edu	37	chr5	179260066	179260066	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atcgatgtggagcacggaggGaaaagaagccgcctgacccc	12	4	14	11	3	0	2	0	1	0	1	1	6	0	5	4	3	2	1	4	3	3	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr5:179260066G>A	uc003mkw.3	+	6	884	c.789G>A	c.(787-789)GGG>GGA	p.G263G	SQSTM1_uc011dgr.1_Silent_p.G179G|SQSTM1_uc011dgs.1_Silent_p.G179G|SQSTM1_uc003mkv.3_Silent_p.G263G|SQSTM1_uc003mkx.2_Silent_p.G179G	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	263					anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCACGGAGGGAAAAGAAGCC	0.587									Paget_Disease_of_Bone				5	76					0	0	0	0	A	179260066	A	A	179260066	2	1	93	1	0	0	0	0	0	0	0	1	15196	1161	41	2		2	SQSTM1	5	179260066	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	5900575	179260066	1655194	70	17985											
PAK1IP1	55003	broad.mit.edu	37	chr6	10707720	10707720	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatcgagtgatggtttcatCaaaatgtggaagcttaagca	13	11	11	6	1	2	1	2	1	0	0	3	3	2	2	0	2	2	4	0	2	4	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:10707720C>A	uc003mzg.2	+	8	844	c.813C>A	c.(811-813)ATC>ATA	p.I271I		NM_017906	NP_060376	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	271	WD 5.				negative regulation of signal transduction	nucleolus|plasma membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				ATGGTTTCATCAAAATGTGGA	0.343													31	124					2.80507e-11	3.01935e-11	1	0	A	10707720	A	A	10707720	2	1	93	1	0	0	0	0	0	0	0	1	11454	816	29	2		2	PAK1IP1	6	10707720	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		10707720	160407347	71	17986											
NEDD9	4739	broad.mit.edu	37	chr6	11213915	11213915	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgcgaaaggccagttcctCggcacactctgggacattgt	8	10	11	12	2	1	0	0	0	1	0	3	2	2	1	2	3	1	2	2	3	1	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:11213915C>T	uc003mzv.2	-	2	225	c.58G>A	c.(58-60)GAG>AAG	p.E20K	NEDD9_uc010joz.2_Missense_Mutation_p.E20K|NEDD9_uc003mzw.3_5'UTR|NEDD9_uc003mzx.2_Missense_Mutation_p.E20K	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	20	SH3.				actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			GCCAGTTCCTCGGCACACTCT	0.522													13	66					0	0	0	0	T	11213915	T	T	11213915	3	4	93	1	0	0	0	0	1	0	0	0	10367	893	31	1	2540	1	NEDD9	6	11213915	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	506195	11213915	159901152	72	17987											
HIST1H3I	8354	broad.mit.edu	37	chr6	27839692	27839692	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gataggaatatttatgccctCtcccctcggatgcggcgcgc	7	10	11	13	4	1	0	0	0	1	0	3	3	1	2	3	3	2	0	3	3	4	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:27839692C>G	uc003njy.2	-	1	408	c.402G>C	c.(400-402)GAG>GAC	p.E134D		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	134					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						TTTATGCCCTCTCCCCTCGGA	0.507													23	233					0	0	0	0	G	27839692	G	G	27839692	3	3	93	1	0	0	0	0	1	0	0	0	7202	912	32	2	12	2	HIST1H3I	6	27839692	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	16625777	27839692	143275375	73	17988											
HIST1H3I	8354	broad.mit.edu	37	chr6	27839802	27839802	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagccccaccaggtaggcctCgcaagcctcctgcagcgcca	8	5	10	18	2	0	0	0	0	0	0	2	0	1	0	7	2	4	3	7	2	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:27839802C>T	uc003njy.2	-	1	298	c.292G>A	c.(292-294)GAG>AAG	p.E98K		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						AGGTAGGCCTCGCAAGCCTCC	0.572													26	105					0	0	0	0	T	27839802	T	T	27839802	3	4	93	1	0	0	0	0	1	0	0	0	7202	893	31	1	122	1	HIST1H3I	6	27839802	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	110	27839802	143275265	74	17989											
NFKBIL1	4795	broad.mit.edu	37	chr6	31516144	31516144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcctgctgcttcggctcGgggctgaccctgcccaccag	3	9	13	16	2	0	1	0	1	0	0	2	1	0	1	4	3	4	4	4	3	0	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:31516144G>A	uc003nub.2	+	2	381	c.262G>A	c.(262-264)GGG>AGG	p.G88R	BAT1_uc003ntv.2_5'Flank|ATP6V1G2_uc003ntz.2_5'Flank|ATP6V1G2_uc003nua.2_5'Flank|NFKBIL1_uc011dnr.1_Missense_Mutation_p.G65R|NFKBIL1_uc011dns.1_Missense_Mutation_p.G65R|NFKBIL1_uc011dnt.1_RNA|NFKBIL1_uc003nuc.2_Missense_Mutation_p.G88R	NM_005007	NP_004998	Q9UBC1	IKBL1_HUMAN	nuclear factor of kappa light polypeptide gene	88	ANK 1.				cytoplasmic sequestering of transcription factor		protein binding				0						GCTTCGGCTCGGGGCTGACCC	0.697													5	13					0	0	0	0	A	31516144	A	A	31516144	3	1	93	1	0	0	0	0	1	0	0	0	10435	1116	39	1	268	1	NFKBIL1	6	31516144	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3676342	31516144	139598923	75	17990											
VPS52	6293	broad.mit.edu	37	chr6	33237329	33237329	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctatattctcactctcttGaatatctgatccacaaaaag	13	14	4	10	0	3	2	1	2	3	0	6	2	4	2	1	0	1	1	1	0	6	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:33237329G>C	uc003odm.1	-	5	520	c.310C>G	c.(310-312)CAA>GAA	p.Q104E	VPS52_uc003odn.1_5'UTR|VPS52_uc003odo.1_Missense_Mutation_p.Q29E|VPS52_uc011dqy.1_5'UTR|VPS52_uc011dqz.1_5'UTR|RPS18_uc003odp.1_5'Flank|RPS18_uc010jum.1_5'Flank	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	104					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						TCACTCTCTTGAATATCTGAT	0.433													27	90					0	0	0	0	C	33237329	C	C	33237329	3	2	93	1	0	0	0	0	1	0	0	0	17282	1299	45	2	1925	2	VPS52	6	33237329	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1721185	33237329	137877738	76	17991											
CUTA	51596	broad.mit.edu	37	chr6	33384884	33384884	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttctcaccatcagcaccTcactgtcttcctcgatcttc	6	15	4	16	1	5	0	3	0	3	0	9	1	6	0	3	0	1	2	3	0	0	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:33384884T>C	uc003oej.1	-	4	641	c.353A>G	c.(352-354)GAG>GGG	p.E118G	CUTA_uc003oek.1_Missense_Mutation_p.E95G|CUTA_uc003oel.1_Missense_Mutation_p.E95G|CUTA_uc003oem.1_Missense_Mutation_p.E95G|CUTA_uc003oen.1_Missense_Mutation_p.E137G|SYNGAP1_uc003oeo.1_5'Flank|SYNGAP1_uc011dri.1_5'Flank|SYNGAP1_uc010juy.2_5'Flank	NM_001014840	NP_001014840	O60888	CUTA_HUMAN	cutA divalent cation tolerance homolog isoform	118					protein localization|response to metal ion	membrane	enzyme binding				0						CATCAGCACCTCACTGTCTTC	0.507													22	70					0	0	0	0	C	33384884	C	C	33384884	3	2	93	1	0	0	0	0	1	0	0	0	4079	1551	54	5	198	5	CUTA	6	33384884	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	147555	33384884	137730183	77	17992											
C6orf106	64771	broad.mit.edu	37	chr6	34614570	34614570	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacccctggaggccaggcctCtgcccctgagttcaagcaaa	10	6	10	15	0	2	1	1	1	1	0	2	2	2	2	6	3	3	2	6	3	3	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:34614570C>G	uc003ojr.2	-	3	564	c.319G>C	c.(319-321)GAG>CAG	p.E107Q	C6orf106_uc003ojs.2_Intron	NM_024294	NP_077270	Q9H6K1	CF106_HUMAN	chromosome 6 open reading frame 106 isoform a	107										skin(2)|ovary(1)	3						GGCCAGGCCTCTGCCCCTGAG	0.458													44	148					0	0	0	0	G	34614570	G	G	34614570	3	3	93	1	0	0	0	0	1	0	0	0	2329	922	32	2	589	2	C6orf106	6	34614570	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	1229686	34614570	136500497	78	17993											
LHFPL5	222662	broad.mit.edu	37	chr6	35773543	35773543	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgtgatgtggggtaccctCaccatctgcttctccgtact	5	12	11	13	2	3	1	1	1	2	0	4	1	3	1	3	3	3	3	3	3	2	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:35773543C>T	uc003olg.1	+	1	473	c.96C>T	c.(94-96)CTC>CTT	p.L32L		NM_182548	NP_872354	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	32	Helical; (Potential).					integral to membrane				skin(1)	1						GGGGTACCCTCACCATCTGCT	0.587													36	103					0	0	0	0	T	35773543	T	T	35773543	2	4	93	1	0	0	0	0	0	0	0	1	8809	813	29	2		2	LHFPL5	6	35773543	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	1158973	35773543	135341524	79	17994											
MEP1A	4224	broad.mit.edu	37	chr6	46793145	46793145	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcccaccatcacagccaaGatccctgagtttaactccat	11	10	5	15	0	1	2	1	1	0	1	4	2	4	2	5	0	2	2	5	0	2	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:46793145G>A	uc010jzh.1	+	8	735	c.693G>A	c.(691-693)AAG>AAA	p.K231K	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Silent_p.K259K|MEP1A_uc011dwi.1_Silent_p.K131K	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	231	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			TCACAGCCAAGATCCCTGAGT	0.428													23	59					0	0	0	0	A	46793145	A	A	46793145	2	1	93	1	0	0	0	0	0	0	0	1	9528	933	33	2		2	MEP1A	6	46793145	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	11019602	46793145	124321922	80	17995											
GPR116	221395	broad.mit.edu	37	chr6	46826148	46826148	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttggtgtcctcccagttGagccaacagacattcttcct	7	12	8	14	0	1	2	0	1	1	1	4	2	4	2	5	1	2	1	5	1	1	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:46826148G>C	uc003oyo.3	-	17	3781	c.3492C>G	c.(3490-3492)CTC>CTG	p.L1164L	GPR116_uc011dwj.1_Silent_p.L719L|GPR116_uc011dwk.1_Silent_p.L593L|GPR116_uc003oyp.3_Silent_p.L1022L|GPR116_uc003oyq.3_Silent_p.L1164L|GPR116_uc010jzi.1_Silent_p.L836L	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	1164	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CCTCCCAGTTGAGCCAACAGA	0.552													18	39					0	0	0	0	C	46826148	C	C	46826148	2	2	93	1	0	0	0	0	0	0	0	1	6671	1277	45	2		2	GPR116	6	46826148	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	33003	46826148	124288919	81	17996											
REV3L	5980	broad.mit.edu	37	chr6	111697184	111697184	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaacatatagtgtgctgcttGctggctgaggcttggctttt	7	15	12	7	0	0	1	0	1	0	0	0	1	0	1	0	3	4	6	0	3	3	6			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:111697184G>A	uc003puy.3	-	13	2697	c.2374C>T	c.(2374-2376)CAA>TAA	p.Q792*	REV3L_uc003pux.3_Nonsense_Mutation_p.Q714*|REV3L_uc003puz.3_Nonsense_Mutation_p.Q714*	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	792					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TGTGCTGCTTGCTGGCTGAGG	0.358								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					26	125					0	0	0	0	A	111697184	A	A	111697184	4	1	93	1	0	0	0	0	0	1	0	0	13305	1328	46	4	7098	4	REV3L	6	111697184	Nonsense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	64871036	111697184	59417883	82	17997											
RFPL4B	442247	broad.mit.edu	37	chr6	112671180	112671180	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgcacgtgagggaggagctCcggcattttcgggaggatgt	7	9	17	8	3	0	1	0	1	0	0	2	5	1	5	1	5	2	3	1	5	0	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:112671180C>G	uc003pvx.1	+	3	582	c.270C>G	c.(268-270)CTC>CTG	p.L90L		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	90	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		GGGAGGAGCTCCGGCATTTTC	0.527													4	55					0	0	0	0	G	112671180	G	G	112671180	2	3	93	1	0	0	0	0	0	0	0	1	13321	842	30	2		2	RFPL4B	6	112671180	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	973996	112671180	58443887	83	17998											
ZUFSP	221302	broad.mit.edu	37	chr6	116987891	116987891	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttttccacagaatggacaTtcaggaggactgtatgttgt	11	14	10	6	0	1	1	1	0	0	1	2	4	2	4	1	3	0	2	1	3	2	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:116987891T>A	uc003pxf.1	-	2	711	c.465A>T	c.(463-465)GAA>GAT	p.E155D	ZUFSP_uc010kef.1_Intron	NM_145062	NP_659499	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	155	C2H2-type 2.					intracellular	zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		AGAATGGACATTCAGGAGGAC	0.373													19	95					0	0	0	0	A	116987891	A	A	116987891	3	1	93	1	0	0	0	0	1	0	0	0	18313	1490	52	5	1307	5	ZUFSP	6	116987891	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	4316711	116987891	54127176	84	17999											
TRDN	10345	broad.mit.edu	37	chr6	123637620	123637620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctgctttggacatcttttCatcttttttagtttcaggtt	6	21	6	8	0	4	0	2	0	2	0	4	1	4	1	1	2	1	3	1	2	1	8			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:123637620C>T	uc003pzj.1	-	24	1514	c.1492G>A	c.(1492-1494)GAA>AAA	p.E498K	TRDN_uc010kem.1_5'UTR	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	498	Lumenal.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		GACATCTTTTCATCTTTTTTA	0.328													19	82					0	0	0	0	T	123637620	T	T	123637620	3	4	93	1	0	0	0	0	1	0	0	0	16535	835	29	2	769	2	TRDN	6	123637620	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	6649729	123637620	47477447	85	18000											
SLC35D3	340146	broad.mit.edu	37	chr6	137245833	137245833	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaggagttacccagtccttGagaaggaggtgcatgtacgt	10	9	14	8	2	0	1	0	1	0	1	1	5	1	3	2	3	3	3	2	3	3	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:137245833G>C	uc003qhe.2	+	2	1415	c.1250G>C	c.(1249-1251)TGA>TCA	p.*417S		NM_001008783	NP_001008783	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	417					carbohydrate transport	integral to membrane				ovary(1)|central_nervous_system(1)	2	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		CCCAGTCCTTGAGAAGGAGGT	0.408													14	37					0	0	0	0	C	137245833	C	C	137245833	4	2	93	1	0	0	0	0	0	0	0	0	14647	1285	45	2	1256	2	SLC35D3	6	137245833	Nonstop_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	13608213	137245833	33869234	86	18001											
TTLL2	83887	broad.mit.edu	37	chr6	167754040	167754040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaagcctgctgagttatctCgtgggagggggatactaatt	9	11	14	7	1	1	1	0	1	1	0	2	3	1	3	1	3	3	3	1	3	4	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr6:167754040C>T	uc003qvs.1	+	3	740	c.652C>T	c.(652-654)CGT>TGT	p.R218C	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	218	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TGAGTTATCTCGTGGGAGGGG	0.423													24	69					0	0	0	0	T	167754040	T	T	167754040	3	4	93	1	0	0	0	0	1	0	0	0	16795	884	31	1	662	1	TTLL2	6	167754040	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	30508207	167754040	3361027	87	18002											
ZNF12	7559	broad.mit.edu	37	chr7	6730809	6730809	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtcgattaagggctgaattCtggcagaaggttttcccaca	10	12	11	8	1	1	2	0	1	1	1	3	3	2	2	1	3	0	3	1	3	3	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:6730809C>T	uc003sqt.1	-	5	2318	c.1764G>A	c.(1762-1764)CAG>CAA	p.Q588Q	ZNF12_uc011jxa.1_Silent_p.Q426Q|ZNF12_uc003sqs.1_Silent_p.Q550Q	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	588	C2H2-type 12.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		GGGCTGAATTCTGGCAGAAGG	0.413													14	43					0	0	0	0	T	6730809	T	T	6730809	2	4	93	1	0	0	0	0	0	0	0	1	17785	912	32	2		2	ZNF12	7	6730809	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		6730809	152407854	88	18003											
THSD7A	221981	broad.mit.edu	37	chr7	11468681	11468681	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacaggacttgctgcagcGcgaccagttggaccactcac	9	6	10	16	2	1	0	1	0	0	0	1	3	1	2	3	2	3	3	3	2	0	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:11468681G>A	uc003ssf.3	-	14	3388	c.3136C>T	c.(3136-3138)CGC>TGC	p.R1046C		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1046	TSP type-1 11.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTGCTGCAGCGCGACCAGTTG	0.517										HNSCC(18;0.044)			63	219					0	0	0	0	A	11468681	A	A	11468681	3	1	93	1	0	0	0	0	1	0	0	0	15945	1087	38	1	1893	1	THSD7A	7	11468681	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	4737872	11468681	147669982	89	18004											
C7orf30	115416	broad.mit.edu	37	chr7	23349102	23349102	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagacagtacctgaagacttCattcttggaatagaagatga	15	10	10	6	0	2	6	1	2	1	4	2	8	2	7	1	1	1	1	1	1	5	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:23349102C>A	uc003swd.1	+	4	677	c.645C>A	c.(643-645)TTC>TTA	p.F215L	C7orf30_uc003swe.2_RNA	NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	215						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			CTGAAGACTTCATTCTTGGAA	0.363													20	70					7.45023e-12	8.04728e-12	1	0	A	23349102	A	A	23349102	3	1	93	1	0	0	0	0	1	0	0	0	2397	825	29	2	659	2	C7orf30	7	23349102	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	11880421	23349102	135789561	90	18005											
STK31	56164	broad.mit.edu	37	chr7	23766884	23766884	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggtggattattttctgaaGatcagtgttggtacagatgc	10	15	12	4	0	2	3	1	1	1	2	2	4	2	4	0	3	2	2	0	3	3	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:23766884G>C	uc003sws.3	+	5	341	c.274G>C	c.(274-276)GAT>CAT	p.D92H	STK31_uc003swt.3_Missense_Mutation_p.D69H|STK31_uc011jze.1_Missense_Mutation_p.D92H|STK31_uc010kuq.2_Missense_Mutation_p.D69H	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	92	Tudor.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						ATTTTCTGAAGATCAGTGTTG	0.289													11	61					0	0	0	0	C	23766884	C	C	23766884	3	2	93	1	0	0	0	0	1	0	0	0	15362	942	33	2	292	2	STK31	7	23766884	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	417782	23766884	135371779	91	18006											
TRIL	9865	broad.mit.edu	37	chr7	28996924	28996924	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcaggtgctggaagatgcGcggcccgaggtgctgcaggt	6	7	19	9	3	0	1	0	0	0	1	0	3	0	2	1	6	4	4	1	6	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:28996924G>C	uc003szt.2	-	3	1106	c.739C>G	c.(739-741)CGC>GGC	p.R247G	uc003szu.1_5'Flank	NM_014817	NP_055632	Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine rich repeats	247	Extracellular (Potential).|LRR 8.				inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding				0						TGGAAGATGCGCGGCCCGAGG	0.697													7	40					0	0	0	0	C	28996924	C	C	28996924	3	2	93	1	0	0	0	0	1	0	0	0	16552	1087	38	3	1700	3	TRIL	7	28996924	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	5230040	28996924	130141739	92	18007											
KBTBD2	25948	broad.mit.edu	37	chr7	32919190	32919190	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacacagcatattcagtattGatctgcctctcgtcttgagt	9	14	8	10	1	4	2	1	2	3	0	5	3	4	2	1	0	2	2	1	0	2	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:32919190G>C	uc003tdb.2	-	2	686	c.27C>G	c.(25-27)ATC>ATG	p.I9M	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	9											0			GBM - Glioblastoma multiforme(11;0.0499)			ATTCAGTATTGATCTGCCTCT	0.388													4	24					0	0	0	0	C	32919190	C	C	32919190	3	2	93	1	0	0	0	0	1	0	0	0	8032	1280	45	2	1856	2	KBTBD2	7	32919190	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3922266	32919190	126219473	93	18008											
BMPER	168667	broad.mit.edu	37	chr7	34118698	34118698	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcagcctgcagcagcacctCaccgtgcgctggaacggctc	7	6	12	16	3	2	0	2	0	0	0	3	1	2	1	3	2	6	5	3	2	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:34118698C>G	uc011kap.1	+	12	1422	c.1308C>G	c.(1306-1308)CTC>CTG	p.L436L		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	436	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						AGCAGCACCTCACCGTGCGCT	0.652													21	97					0	0	0	0	G	34118698	G	G	34118698	2	3	93	1	0	0	0	0	0	0	0	1	1471	813	29	2		2	BMPER	7	34118698	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	1199508	34118698	125019965	94	18009											
HECW1	23072	broad.mit.edu	37	chr7	43591890	43591890	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggtgatagctggcaccgcgGaaatcgacctaaatgactgg	11	8	13	9	3	0	2	0	2	0	0	1	4	0	3	2	4	1	2	2	4	4	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:43591890G>A	uc003tid.1	+	28	5070	c.4465G>A	c.(4465-4467)GAA>AAA	p.E1489K	HECW1_uc011kbi.1_Missense_Mutation_p.E1455K	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1489	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TGGCACCGCGGAAATCGACCT	0.522													25	95					0	0	0	0	A	43591890	A	A	43591890	3	1	93	1	0	0	0	0	1	0	0	0	7081	1175	41	2	4567	2	HECW1	7	43591890	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	9473192	43591890	115546773	95	18010											
AUTS2	26053	broad.mit.edu	37	chr7	70255920	70255920	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcccagaaggacgactcctCtgtccgcagagataagggag	11	6	12	12	2	1	2	0	0	1	2	4	6	4	4	3	2	0	1	3	2	2	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:70255920C>T	uc003tvw.3	+	19	4461	c.3718C>T	c.(3718-3720)CTG>TTG	p.L1240L	AUTS2_uc003tvx.3_Silent_p.L1216L|AUTS2_uc011keg.1_Silent_p.L692L	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1240										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GACGACTCCTCTGTCCGCAGA	0.622													6	20					0	0	0	0	T	70255920	T	T	70255920	2	4	93	1	0	0	0	0	0	0	0	1	1227	912	32	2		2	AUTS2	7	70255920	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	26664030	70255920	88882743	96	18011											
SRRM3	222183	broad.mit.edu	37	chr7	75894128	75894128	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagagaagaacaaagagaaGaagaggtaagcgccctccct	19	3	11	8	1	0	5	0	0	0	5	1	7	1	5	2	1	2	1	2	1	7	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:75894128G>C	uc010ldi.2	+	9	929	c.720G>C	c.(718-720)AAG>AAC	p.K240N	SRRM3_uc011kgi.1_5'Flank	NM_001110199	NP_001103669			serine/arginine repetitive matrix 3												0						ACAAAGAgaagaagaggtaag	0.269													11	43					0	0	0	0	C	75894128	C	C	75894128	3	2	93	1	0	0	0	0	1	0	0	0	15236	933	33	2	750	2	SRRM3	7	75894128	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	5638208	75894128	83244535	97	18012											
SEMA3C	10512	broad.mit.edu	37	chr7	80418764	80418764	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggaattgtacatgagaggAtggttccgaataaaagtgac	15	10	12	4	1	0	2	0	2	0	1	1	6	1	4	1	3	1	2	1	3	5	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:80418764A>G	uc003uhj.2	-	12	1774	c.1212T>C	c.(1210-1212)CAT>CAC	p.H404H	SEMA3C_uc011kgw.1_Silent_p.H422H	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	404	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						ACATGAGAGGATGGTTCCGAA	0.418													16	125					0	0	0	0	G	80418764	G	G	80418764	2	3	93	1	0	0	0	0	0	0	0	1	14091	330	12	5		5	SEMA3C	7	80418764	Silent	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	4524636	80418764	78719899	98	18013											
ZNF3	7551	broad.mit.edu	37	chr7	99669200	99669200	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaccagtgtggattctctGatggtgggtgagggtggagc	6	11	17	7	0	2	2	1	2	1	0	3	4	2	4	1	5	1	0	1	5	0	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:99669200G>C	uc003usq.2	-	6	1214	c.907C>G	c.(907-909)CAG>GAG	p.Q303E	ZNF3_uc003usp.2_Intron|ZNF3_uc003usr.2_Missense_Mutation_p.Q303E|ZNF3_uc010lgj.2_Missense_Mutation_p.Q267E|ZNF3_uc003uss.2_Missense_Mutation_p.Q310E|ZNF3_uc003ust.3_Missense_Mutation_p.Q303E	NM_032924	NP_116313	P17036	ZNF3_HUMAN	zinc finger protein 3 isoform 2	303	C2H2-type 4.				cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			TGGATTCTCTGATGGTGGGTG	0.532													12	49					0	0	0	0	C	99669200	C	C	99669200	3	2	93	1	0	0	0	0	1	0	0	0	17896	1299	45	2	566	2	ZNF3	7	99669200	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	19250436	99669200	59469463	99	18014											
MCM7	4176	broad.mit.edu	37	chr7	99694942	99694942	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgcgaggcgccagtcgatCaatgtatgacaggagctgag	11	7	14	9	3	1	2	1	2	0	0	2	5	1	3	1	2	2	2	1	2	2	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:99694942C>G	uc003usw.1	-	10	1693	c.1183G>C	c.(1183-1185)GAT>CAT	p.D395H	MCM7_uc003usv.1_Missense_Mutation_p.D219H|MCM7_uc003usx.1_Missense_Mutation_p.D219H	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	395	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	GCCAGTCGATCAATGTATGAC	0.507													13	53					0	0	0	0	G	99694942	G	G	99694942	3	3	93	1	0	0	0	0	1	0	0	0	9445	826	29	2	1000	2	MCM7	7	99694942	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	25742	99694942	59443721	100	18015											
SLC26A5	375611	broad.mit.edu	37	chr7	103050935	103050935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgcggtggtaaacccaCggaccagaggctctgtgaga	9	7	14	11	2	1	2	0	1	1	2	1	4	1	3	2	4	3	3	2	4	2	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:103050935C>T	uc003vbz.2	-	7	868	c.632G>A	c.(631-633)CGT>CAT	p.R211H	SLC26A5_uc003vbt.1_Missense_Mutation_p.R211H|SLC26A5_uc003vbu.1_Missense_Mutation_p.R211H|SLC26A5_uc003vbv.1_Missense_Mutation_p.R211H|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.R211H|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	211	Cytoplasmic (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						GGTAAACCCACGGACCAGAGG	0.413													11	48					0	0	0	0	T	103050935	T	T	103050935	3	4	93	1	0	0	0	0	1	0	0	0	14584	536	19	1	1699	1	SLC26A5	7	103050935	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	3355993	103050935	56087728	101	18016											
HBP1	26959	broad.mit.edu	37	chr7	106836328	106836328	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagtttatgtgttaagtagtAtggctcgccagcgtcgtgca	8	13	12	8	3	0	0	0	0	0	0	2	0	0	0	1	1	2	6	1	1	4	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:106836328A>G	uc003vdy.2	+	9	1303	c.1117A>G	c.(1117-1119)ATG>GTG	p.M373V	HBP1_uc011klv.1_Missense_Mutation_p.M383V|HBP1_uc003vdz.2_Missense_Mutation_p.M373V|HBP1_uc003vea.2_Missense_Mutation_p.M373V|HBP1_uc003veb.1_Missense_Mutation_p.M373V	NM_012257	NP_036389	O60381	HBP1_HUMAN	HMG-box transcription factor 1	373					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			skin(1)	1						GTTAAGTAGTATGGCTCGCCA	0.373													34	85					0	0	0	0	G	106836328	G	G	106836328	3	3	93	1	0	0	0	0	1	0	0	0	7024	449	16	5	1147	5	HBP1	7	106836328	Missense_Mutation	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	3785393	106836328	52302335	102	18017											
MKLN1	4289	broad.mit.edu	37	chr7	131155605	131155605	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgtacattttctaggtttGaagaaaaggcccaagtggat	12	13	11	5	0	1	2	0	1	1	1	1	3	1	3	1	3	1	2	1	3	6	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:131155605G>A	uc011kpm.1	+	16	1997	c.1933G>A	c.(1933-1935)GAA>AAA	p.E645K	MKLN1_uc011kpl.1_Missense_Mutation_p.E622K|MKLN1_uc010lmh.2_Missense_Mutation_p.E645K|MKLN1_uc003vqs.2_Missense_Mutation_p.E438K|MKLN1_uc003vqu.2_Missense_Mutation_p.E135K|MKLN1_uc003vqv.1_RNA	NM_013255	NP_037387	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing	645	Kelch 6.				signal transduction	cytoplasm	protein binding			breast(1)	1	Melanoma(18;0.162)					TTCTAGGTTTGAAGAAAAGGC	0.343													13	49					0	0	0	0	A	131155605	A	A	131155605	3	1	93	1	0	0	0	0	1	0	0	0	9656	1291	45	2	2028	2	MKLN1	7	131155605	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	24319277	131155605	27983058	103	18018											
EXOC4	60412	broad.mit.edu	37	chr7	132959795	132959795	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaaaagggtcgccttgaaGaagcctacgagaaatgtgac	15	7	12	7	2	0	5	0	3	0	2	1	6	0	5	2	1	2	0	2	1	6	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:132959795G>C	uc003vrk.2	+	2	180	c.145G>C	c.(145-147)GAA>CAA	p.E49Q	EXOC4_uc011kpo.1_5'UTR|EXOC4_uc003vri.2_Missense_Mutation_p.E49Q|EXOC4_uc003vrj.2_Missense_Mutation_p.E49Q	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	49	Potential.				vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				TCGCCTTGAAGAAGCCTACGA	0.458													25	56					0	0	0	0	C	132959795	C	C	132959795	3	2	93	1	0	0	0	0	1	0	0	0	5330	943	33	2	151	2	EXOC4	7	132959795	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1804190	132959795	26178868	104	18019											
OR9A4	130075	broad.mit.edu	37	chr7	141618814	141618814	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacacagtcatcatcatgAttgtctgtgtggataaacgt	13	12	9	7	1	4	1	3	1	1	0	4	3	4	2	0	1	2	0	0	1	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:141618814A>T	uc003vwu.1	+	1	139	c.139A>T	c.(139-141)ATT>TTT	p.I47F		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	47	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					CATCATCATGATTGTCTGTGT	0.458													46	113					0	0	0	0	T	141618814	T	T	141618814	3	4	93	1	0	0	0	0	1	0	0	0	11303	333	12	5	141	5	OR9A4	7	141618814	Missense_Mutation	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	8659019	141618814	17519849	105	18020											
FAM115A	9747	broad.mit.edu	37	chr7	143573171	143573171	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaagtaaatgccagccacActggtcacgaggttcccagg	12	7	11	11	1	1	0	1	0	0	0	2	1	2	0	3	3	2	3	3	3	4	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:143573171A>T	uc003wdo.1	-	2	664	c.531T>A	c.(529-531)AGT>AGA	p.S177R	FAM115A_uc011ktu.1_Intron|FAM115A_uc003wdp.1_Missense_Mutation_p.S177R	NM_014719	NP_055534	Q9Y4C2	F115A_HUMAN	hypothetical protein LOC9747	177											0	Melanoma(164;0.0903)					TGCCAGCCACACTGGTCACGA	0.517													12	27					0	0	0	0	T	143573171	T	T	143573171	3	4	93	1	0	0	0	0	1	0	0	0	5433	156	6	5	2266	5	FAM115A	7	143573171	Missense_Mutation	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	1954357	143573171	15565492	106	18021											
OR2A2	442361	broad.mit.edu	37	chr7	143807023	143807023	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtgcctgattttggtggtGatgtcctatgataggtatgt	7	16	14	4	0	0	3	0	3	0	0	1	4	1	3	2	3	1	1	2	3	3	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr7:143807023G>A	uc011ktz.1	+	1	348	c.348G>A	c.(346-348)GTG>GTA	p.V116V		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					TTTTGGTGGTGATGTCCTATG	0.453													47	93					0	0	0	0	A	143807023	A	A	143807023	2	1	93	1	0	0	0	0	0	0	0	1	11031	1277	45	2		2	OR2A2	7	143807023	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	233852	143807023	15331640	107	18022											
ANK1	286	broad.mit.edu	37	chr8	41557008	41557008	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaaaatccagcagctccttCtcttcatcaacatccctgga	12	10	4	15	0	3	0	2	0	1	0	7	1	6	1	3	1	3	2	3	1	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr8:41557008C>G	uc003xok.2	-	23	2604	c.2520G>C	c.(2518-2520)GAG>GAC	p.E840D	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.E156D|ANK1_uc003xoi.2_Missense_Mutation_p.E840D|ANK1_uc003xoj.2_Missense_Mutation_p.E840D|ANK1_uc003xol.2_Missense_Mutation_p.E840D|ANK1_uc003xom.2_Missense_Mutation_p.E881D	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	840					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GCAGCTCCTTCTCTTCATCAA	0.577													3	160					0	0	0	0	G	41557008	G	G	41557008	3	3	93	1	0	0	0	0	1	0	0	0	620	912	32	2	3531	2	ANK1	8	41557008	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		41557008	104807014	108	18023											
STMN2	11075	broad.mit.edu	37	chr8	80577108	80577108	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggttgaactgtctggctGaagcaagggagggtctggca	9	8	16	8	0	2	2	0	2	2	0	2	3	2	3	1	5	2	4	1	5	3	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr8:80577108G>A	uc003ybj.2	+	5	590	c.539G>A	c.(538-540)TGA>TAA	p.*180*	STMN2_uc010lzp.2_RNA|STMN2_uc011lfn.1_Intron|STMN2_uc003ybk.2_RNA	NM_007029	NP_008960	Q93045	STMN2_HUMAN	superiorcervical ganglia, neural specific 10	180					intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			CTGTCTGGCTGAAGCAAGGGA	0.483													11	24					0	0	0	0	A	80577108	A	A	80577108	2	1	93	1	0	0	0	0	0	0	0	1	15375	1285	45	2		2	STMN2	8	80577108	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	39020100	80577108	65786914	109	18024											
SYBU	55638	broad.mit.edu	37	chr8	110592224	110592224	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccattactccgcccatgagGacctcgactgggagaaaaga	12	7	10	12	2	0	3	0	1	0	2	3	6	2	4	4	2	1	0	4	2	3	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr8:110592224G>A	uc003ynj.3	-	5	701	c.538C>T	c.(538-540)CCT>TCT	p.P180S	SYBU_uc003yni.3_Missense_Mutation_p.P177S|SYBU_uc003ynk.3_Missense_Mutation_p.P61S|SYBU_uc010mco.2_Missense_Mutation_p.P179S|SYBU_uc003ynl.3_Missense_Mutation_p.P179S|SYBU_uc010mcp.2_Missense_Mutation_p.P180S|SYBU_uc010mcq.2_Missense_Mutation_p.P180S|SYBU_uc003yno.3_Missense_Mutation_p.P61S|SYBU_uc010mcr.2_Missense_Mutation_p.P180S|SYBU_uc003ynm.3_Missense_Mutation_p.P179S|SYBU_uc003ynn.3_Missense_Mutation_p.P179S|SYBU_uc010mcs.2_Missense_Mutation_p.P61S|SYBU_uc010mct.2_Missense_Mutation_p.P180S|SYBU_uc010mcu.2_Missense_Mutation_p.P179S|SYBU_uc003ynp.3_Missense_Mutation_p.P112S|SYBU_uc010mcv.2_Missense_Mutation_p.P180S|SYBU_uc003ynh.3_5'UTR|SYBU_uc011lhw.1_Missense_Mutation_p.P50S	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	180	Sufficient for interaction with KIF5B.|Ser-rich.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						CGCCCATGAGGACCTCGACTG	0.483													28	164					0	0	0	0	A	110592224	A	A	110592224	3	1	93	1	0	0	0	0	1	0	0	0	15493	1174	41	2	1465	2	SYBU	8	110592224	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	30015116	110592224	35771798	110	18025											
KIAA0196	9897	broad.mit.edu	37	chr8	126051188	126051188	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgatagtgggcttcaatgtCtgctaggagagccctaaagg	10	10	13	8	0	2	2	1	1	1	1	2	3	2	2	1	3	2	2	1	3	5	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr8:126051188C>G	uc003yrt.2	-	25	3297	c.2968G>C	c.(2968-2970)GAC>CAC	p.D990H	KIAA0196_uc011lir.1_Missense_Mutation_p.D842H|KIAA0196_uc003yru.1_Missense_Mutation_p.D564H	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	990					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GCTTCAATGTCTGCTAGGAGA	0.353													53	149					0	0	0	0	G	126051188	G	G	126051188	3	3	93	1	0	0	0	0	1	0	0	0	8200	913	32	2	531	2	KIAA0196	8	126051188	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	15458964	126051188	20312834	111	18026											
ZC3H3	23144	broad.mit.edu	37	chr8	144621295	144621295	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggagggtctgagggtcccGggggccgattcacgagggag	7	5	20	9	3	2	1	1	1	1	0	3	5	3	3	2	6	0	0	2	6	0	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr8:144621295G>A	uc003yyd.2	-	2	271	c.242C>T	c.(241-243)CCG>CTG	p.P81L		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	81					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			TGAGGGTCCCGGGGGCCGATT	0.667													36	114					0	0	0	0	A	144621295	A	A	144621295	3	1	93	1	0	0	0	0	1	0	0	0	17636	1116	39	1	2648	1	ZC3H3	8	144621295	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	18570107	144621295	1742727	112	18027											
ZNF707	286075	broad.mit.edu	37	chr8	144776617	144776617	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctgacgaagaggttctacGagtgcggccactgtgggaaa	11	7	14	9	3	1	2	0	1	1	1	1	5	1	3	2	3	2	1	2	3	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr8:144776617G>A	uc003yze.3	+	7	1348	c.1033G>A	c.(1033-1035)GAG>AAG	p.E345K	ZNF707_uc010mfh.2_Missense_Mutation_p.E345K|ZNF707_uc010mfi.2_Missense_Mutation_p.E345K|ZNF707_uc003yzf.3_Missense_Mutation_p.E345K|ZNF707_uc003yzh.3_Missense_Mutation_p.E272K|ZNF707_uc011lkq.1_RNA|BREA2_uc010mfj.1_5'Flank	NM_173831	NP_776192	Q96C28	ZN707_HUMAN	zinc finger protein 707	345	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;5.6e-41)|Epithelial(56;1.02e-39)|all cancers(56;9.65e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GAGGTTCTACGAGTGCGGCCA	0.647													9	26					0	0	0	0	A	144776617	A	A	144776617	3	1	93	1	0	0	0	0	1	0	0	0	18178	1059	37	1	1047	1	ZNF707	8	144776617	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	155322	144776617	1587405	113	18028											
PLEC	5339	broad.mit.edu	37	chr8	145011230	145011230	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcatcattcctgatgttcaCcagcttcacctgtgagcgag	8	12	9	12	1	4	2	4	2	0	0	5	3	5	2	3	0	2	2	3	0	0	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr8:145011230C>A	uc003zaf.1	-	5	933	c.763G>T	c.(763-765)GTG>TTG	p.V255L	PLEC_uc003zab.1_Missense_Mutation_p.V118L|PLEC_uc003zac.1_Missense_Mutation_p.V122L|PLEC_uc003zad.2_Missense_Mutation_p.V118L|PLEC_uc003zae.1_Missense_Mutation_p.V86L|PLEC_uc003zag.1_Missense_Mutation_p.V96L|PLEC_uc003zah.2_Missense_Mutation_p.V104L|PLEC_uc003zaj.2_Missense_Mutation_p.V145L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	255	CH 1.|Globular 1.|Actin-binding.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTGATGTTCACCAGCTTCACC	0.642													50	67					1.07234e-20	1.19149e-20	1	0	A	145011230	A	A	145011230	3	1	93	1	0	0	0	0	1	0	0	0	12107	507	18	4	13403	4	PLEC	8	145011230	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	234613	145011230	1352792	114	18029											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			5	13					0	0	0	0	A	21971120	A	A	21971120	4	1	93	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08		21971120	119242311	115	18030											
MAMDC2	256691	broad.mit.edu	37	chr9	72755126	72755126	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctctgcaacttttaccaaGataaagaaggtccaggttgg	13	11	9	8	0	1	2	0	0	1	2	3	2	2	2	2	3	3	2	2	3	6	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr9:72755126G>C	uc004ahm.2	+	8	1677	c.1060G>C	c.(1060-1062)GAT>CAT	p.D354H	MAMDC2_uc004ahn.2_RNA	NM_153267	NP_694999	Q7Z304	MAMC2_HUMAN	MAM domain containing 2 precursor	354	MAM 3.					endoplasmic reticulum|membrane				central_nervous_system(1)|pancreas(1)	2						CTTTTACCAAGATAAAGAAGG	0.453													28	115					0	0	0	0	C	72755126	C	C	72755126	3	2	93	1	0	0	0	0	1	0	0	0	9256	942	33	2	1090	2	MAMDC2	9	72755126	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	50784006	72755126	68458305	116	18031											
MAMDC2	256691	broad.mit.edu	37	chr9	72758548	72758548	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctatgggccctccctaccagGaaacttgcagtattgtctgc	8	11	9	13	0	1	0	0	0	1	0	2	1	2	1	3	2	4	2	3	2	4	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr9:72758548G>C	uc004ahm.2	+	9	1834	c.1217G>C	c.(1216-1218)GGA>GCA	p.G406A	MAMDC2_uc004ahn.2_RNA	NM_153267	NP_694999	Q7Z304	MAMC2_HUMAN	MAM domain containing 2 precursor	406	MAM 3.					endoplasmic reticulum|membrane				central_nervous_system(1)|pancreas(1)	2						TCCCTACCAGGAAACTTGCAG	0.423													24	82					0	0	0	0	C	72758548	C	C	72758548	3	2	93	1	0	0	0	0	1	0	0	0	9256	1174	41	2	1251	2	MAMDC2	9	72758548	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3422	72758548	68454883	117	18032											
SECISBP2	79048	broad.mit.edu	37	chr9	91973689	91973689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggatgtaccctggagctaGaagaatccttggaggcttca	10	10	13	8	0	1	2	1	0	0	2	2	5	2	5	2	4	2	3	2	4	4	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr9:91973689G>A	uc004aqj.1	+	17	2595	c.2515G>A	c.(2515-2517)GAA>AAA	p.E839K	SECISBP2_uc011ltk.1_Missense_Mutation_p.E838K|SECISBP2_uc004aqk.1_Missense_Mutation_p.E766K|SECISBP2_uc010mqo.1_Missense_Mutation_p.E544K|SECISBP2_uc011ltl.1_Missense_Mutation_p.E771K	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	839					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						CCTGGAGCTAGAAGAATCCTT	0.413													7	41					0	0	0	0	A	91973689	A	A	91973689	3	1	93	1	0	0	0	0	1	0	0	0	14071	943	33	2	2581	2	SECISBP2	9	91973689	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	19215141	91973689	49239742	118	18033											
WNK2	65268	broad.mit.edu	37	chr9	96054670	96054670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcccatgtggtccccagcGtcccccaggtaagggcgact	7	7	11	16	2	0	0	0	0	0	0	3	1	3	0	5	3	1	1	5	3	1	1	rs140544829		TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr9:96054670G>A	uc004ati.1	+	22	5128	c.5128G>A	c.(5128-5130)GTC>ATC	p.V1710I	WNK2_uc011lud.1_Missense_Mutation_p.V1673I|WNK2_uc004atj.2_Missense_Mutation_p.V1673I|WNK2_uc004atk.2_Missense_Mutation_p.V1310I|WNK2_uc004atl.1_Missense_Mutation_p.V267I	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1710					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						GGTCCCCAGCGTCCCCCAGGT	0.562													75	93					0	0	0	0	A	96054670	A	A	96054670	3	1	93	1	0	0	0	0	1	0	0	0	17446	1145	40	1	5099	1	WNK2	9	96054670	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	4080981	96054670	45158761	119	18034											
ROD1	9991	broad.mit.edu	37	chr9	114986137	114986137	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcacagaaaagtcagatTgtagattttgagaaggaaac	18	10	9	4	0	2	4	2	1	0	4	2	6	2	5	0	1	1	1	0	1	6	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr9:114986137T>C	uc004bfw.2	-	15	1840	c.1653A>G	c.(1651-1653)ACA>ACG	p.T551T	ROD1_uc004bfv.2_Silent_p.T557T|ROD1_uc004bfx.2_Silent_p.T554T|ROD1_uc011lwu.1_Silent_p.T523T|ROD1_uc004bfy.2_Silent_p.T456T|ROD1_uc004bfz.2_Intron	NM_005156	NP_005147	O95758	ROD1_HUMAN	ROD1 regulator of differentiation 1 isoform 1	551					anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1						AAAGTCAGATTGTAGATTTTG	0.393													68	76					0	0	0	0	C	114986137	C	C	114986137	2	2	93	1	0	0	0	0	0	0	0	1	13584	1799	63	5		5	ROD1	9	114986137	Silent	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	18931467	114986137	26227294	120	18035											
GARNL3	84253	broad.mit.edu	37	chr9	130111290	130111290	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccttgctggtttccactGatgctggcgtcttgctagtg	4	14	13	10	1	1	1	0	1	1	0	2	1	2	1	2	3	3	4	2	3	1	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr9:130111290G>T	uc011mae.1	+	17	1920	c.1519G>T	c.(1519-1521)GAT>TAT	p.D507Y	GARNL3_uc011mad.1_Missense_Mutation_p.D485Y	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	507	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GGTTTCCACTGATGCTGGCGT	0.502													22	71					1.55469e-16	1.69107e-16	1	0	T	130111290	T	T	130111290	3	4	93	1	0	0	0	0	1	0	0	0	6276	1290	45	2	1585	2	GARNL3	9	130111290	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	15125153	130111290	11102141	121	18036											
NAIF1	203245	broad.mit.edu	37	chr9	130828916	130828916	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgcggtggccgagggtccGagggccacagggtggatctc	5	6	19	11	3	1	0	0	0	1	0	3	3	2	1	3	6	1	1	3	6	0	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr9:130828916G>A	uc004bta.2	-	1	684	c.465C>T	c.(463-465)CTC>CTT	p.L155L	NAIF1_uc004bsz.2_Intron|SLC25A25_uc004btb.2_5'Flank	NM_197956	NP_931045	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	155					apoptosis|induction of apoptosis	nucleus					0						CCGAGGGTCCGAGGGCCACAG	0.652													6	71					0	0	0	0	A	130828916	A	A	130828916	2	1	93	1	0	0	0	0	0	0	0	1	10199	1045	37	1		1	NAIF1	9	130828916	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	717626	130828916	10384515	122	18037											
SPTAN1	6709	broad.mit.edu	37	chr9	131348114	131348114	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccaaagcttcccagcgtcGgcaggacctggaggactctc	9	6	12	14	2	1	0	0	0	1	0	4	3	2	3	3	4	3	2	3	4	1	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr9:131348114G>A	uc004bvl.3	+	19	2761	c.2648G>A	c.(2647-2649)CGG>CAG	p.R883Q	SPTAN1_uc011mbg.1_Missense_Mutation_p.R883Q|SPTAN1_uc011mbh.1_Missense_Mutation_p.R895Q|SPTAN1_uc004bvm.3_Missense_Mutation_p.R883Q|SPTAN1_uc004bvn.3_Missense_Mutation_p.R883Q	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	883	Spectrin 9.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TCCCAGCGTCGGCAGGACCTG	0.562													27	83					0	0	0	0	A	131348114	A	A	131348114	3	1	93	1	0	0	0	0	1	0	0	0	15183	1116	39	1	2718	1	SPTAN1	9	131348114	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	519198	131348114	9865317	123	18038											
RAPGEF1	2889	broad.mit.edu	37	chr9	134501394	134501394	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtaaaatcacccacaaattcGacaggggctgaggaacctcc	14	6	9	12	1	1	1	1	1	0	0	3	3	2	2	3	3	1	2	3	3	4	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr9:134501394G>A	uc004cbc.2	-	10	1696	c.1566C>T	c.(1564-1566)GTC>GTT	p.V522V	RAPGEF1_uc004cbb.2_Silent_p.V540V|RAPGEF1_uc010mzm.2_RNA|RAPGEF1_uc010mzn.2_Silent_p.V527V|RAPGEF1_uc004cbd.2_Silent_p.V527V	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	522					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		CCACAAATTCGACAGGGGCTG	0.542													18	59					0	0	0	0	A	134501394	A	A	134501394	2	1	93	1	0	0	0	0	0	0	0	1	13108	1045	37	1		1	RAPGEF1	9	134501394	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3153280	134501394	6712037	124	18039											
FAM107B	83641	broad.mit.edu	37	chr10	14816385	14816385	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggccgcagtgcggtgacttGaattccgattcgcactgcca	7	9	13	12	4	0	2	0	2	0	0	2	3	1	2	3	2	2	2	3	2	1	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:14816385G>C	uc001ina.1	-	1	512	c.278C>G	c.(277-279)TCA>TGA	p.S93*	FAM107B_uc010qbu.1_RNA	NM_031453	NP_113641	Q9H098	F107B_HUMAN	hypothetical protein LOC83641	Error:Variant_position_missing_in_Q9H098_after_alignment										breast(4)	4						GCGGTGACTTGAATTCCGATT	0.597													53	118					0	0	0	0	C	14816385	C	C	14816385	4	2	93	1	0	0	0	0	0	1	0	0	5418	1294	45	2	662	2	FAM107B	10	14816385	Nonsense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08		14816385	120718362	125	18040											
GPRIN2	9721	broad.mit.edu	37	chr10	46999441	46999441	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gagacttctaactcagcctgGatgctgggggcgagtcagtt	8	10	14	9	1	3	1	2	0	1	1	3	4	3	2	1	3	3	2	1	3	1	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:46999441G>C	uc001jec.2	+	3	696	c.561G>C	c.(559-561)TGG>TGC	p.W187C	GPRIN2_uc010qfq.1_5'Flank	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	187											0						ACTCAGCCTGGATGCTGGGGG	0.627													9	37					0	0	0	0	C	46999441	C	C	46999441	3	2	93	1	0	0	0	0	1	0	0	0	6769	1183	41	2	563	2	GPRIN2	10	46999441	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	32183056	46999441	88535306	126	18041											
RBP3	5949	broad.mit.edu	37	chr10	48390446	48390446	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaactcccccatcatgctCagcacctcctggcccgggac	8	6	9	18	1	2	0	2	0	0	0	4	2	4	2	5	3	3	2	5	3	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:48390446C>G	uc001jez.2	-	1	546	c.432G>C	c.(430-432)CTG>CTC	p.L144L		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	144	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CCATCATGCTCAGCACCTCCT	0.642													19	76					0	0	0	0	G	48390446	G	G	48390446	2	3	93	1	0	0	0	0	0	0	0	1	13222	813	29	2		2	RBP3	10	48390446	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	1391005	48390446	87144301	127	18042											
SLC18A3	6572	broad.mit.edu	37	chr10	50819200	50819200	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctatcctgcagctgctagtGaaccccttgagcgggccctt	6	10	11	14	1	0	2	0	2	0	0	1	2	1	2	4	1	5	4	4	1	3	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:50819200G>C	uc001jhw.2	+	1	854	c.414G>C	c.(412-414)GTG>GTC	p.V138V	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	138	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						AGCTGCTAGTGAACCCCTTGA	0.632													29	80					0	0	0	0	C	50819200	C	C	50819200	2	2	93	1	0	0	0	0	0	0	0	1	14492	1277	45	2		2	SLC18A3	10	50819200	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	2428754	50819200	84715547	128	18043											
PCDH15	65217	broad.mit.edu	37	chr10	55566626	55566626	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcagaggtacattctcctCatgtgtcactgccaacttgt	8	14	8	11	0	4	1	3	0	1	1	5	1	4	1	2	1	3	2	2	1	2	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:55566626C>A	uc010qhq.1	-	36	5157	c.4762G>T	c.(4762-4764)GAG>TAG	p.E1588*	PCDH15_uc010qhr.1_Nonsense_Mutation_p.E1583*	NM_001142771	NP_001136243	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD3-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACATTCTCCTCATGTGTCACT	0.488										HNSCC(58;0.16)			18	311					5.3912e-06	5.66533e-06	1	0	A	55566626	A	A	55566626	4	1	93	1	0	0	0	0	0	1	0	0	11565	835	29	2	290	2	PCDH15	10	55566626	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	4747426	55566626	79968121	129	18044											
PCDH15	65217	broad.mit.edu	37	chr10	55826607	55826607	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacactggagcattgtcattGacatctgtcaccactatgtt	11	13	7	10	0	3	1	2	1	1	0	3	2	3	2	1	1	2	2	1	1	2	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:55826607G>C	uc001jju.1	-	18	2525	c.2130C>G	c.(2128-2130)GTC>GTG	p.V710V	PCDH15_uc010qhq.1_Silent_p.V715V|PCDH15_uc010qhr.1_Silent_p.V710V|PCDH15_uc010qhs.1_Silent_p.V722V|PCDH15_uc010qht.1_Silent_p.V717V|PCDH15_uc010qhu.1_Silent_p.V710V|PCDH15_uc001jjv.1_Silent_p.V688V|PCDH15_uc010qhv.1_Silent_p.V710V|PCDH15_uc010qhw.1_Silent_p.V673V|PCDH15_uc010qhx.1_Silent_p.V639V|PCDH15_uc010qhy.1_Silent_p.V715V|PCDH15_uc010qhz.1_Silent_p.V710V|PCDH15_uc010qia.1_Silent_p.V688V|PCDH15_uc010qib.1_Silent_p.V688V|PCDH15_uc001jjw.2_Silent_p.V710V	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	710	Cadherin 6.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CATTGTCATTGACATCTGTCA	0.373										HNSCC(58;0.16)			16	65					0	0	0	0	C	55826607	C	C	55826607	2	2	93	1	0	0	0	0	0	0	0	1	11565	1277	45	2		2	PCDH15	10	55826607	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	259981	55826607	79708140	130	18045											
MYPN	84665	broad.mit.edu	37	chr10	69934302	69934302	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgtccccaattcctgtctCtcctaccagccggattcaga	7	12	7	15	1	2	1	1	0	1	1	6	2	5	2	6	1	2	0	6	1	2	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:69934302C>G	uc001jnm.3	+	12	2638	c.2453C>G	c.(2452-2454)TCT>TGT	p.S818C	MYPN_uc001jnn.3_Missense_Mutation_p.S543C|MYPN_uc001jno.3_Missense_Mutation_p.S818C|MYPN_uc009xpt.2_Missense_Mutation_p.S818C|MYPN_uc010qit.1_Missense_Mutation_p.S524C|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	818	Pro-rich.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						ATTCCTGTCTCTCCTACCAGC	0.567													20	67					0	0	0	0	G	69934302	G	G	69934302	3	3	93	1	0	0	0	0	1	0	0	0	10151	913	32	2	2491	2	MYPN	10	69934302	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	14107695	69934302	65600445	131	18046											
VCL	7414	broad.mit.edu	37	chr10	75855484	75855484	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gttatgatggggccttatcgGcaagatcttctcgccaagtg	8	12	12	9	2	2	2	0	1	2	1	4	2	2	2	2	3	0	2	2	3	4	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:75855484G>A	uc001jwd.2	+	12	1708	c.1614G>A	c.(1612-1614)CGG>CGA	p.R538R	VCL_uc009xrr.2_Silent_p.R287R|VCL_uc010qky.1_Silent_p.R445R|VCL_uc001jwe.2_Silent_p.R538R|VCL_uc010qkz.1_Intron	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	538	N-terminal globular head.|3.|3 X 112 AA tandem repeats.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					GGCCTTATCGGCAAGATCTTC	0.582													4	168					0	0	0	0	A	75855484	A	A	75855484	2	1	93	1	0	0	0	0	0	0	0	1	17207	1190	42	4		4	VCL	10	75855484	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	5921182	75855484	59679263	132	18047											
DLG5	9231	broad.mit.edu	37	chr10	79581243	79581243	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctcttggagggctggggaGagtgagcaggcccaggacct	7	6	17	11	0	1	2	0	1	1	1	1	5	1	4	3	6	1	2	3	6	0	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:79581243G>A	uc001jzk.2	-	15	3069	c.2999C>T	c.(2998-3000)TCT>TTT	p.S1000F	DLG5_uc001jzi.2_5'Flank|DLG5_uc001jzj.2_Intron|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.S604F	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1000	Pro-rich.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GGGCTGGGGAGAGTGAGCAGG	0.572													53	108					0	0	0	0	A	79581243	A	A	79581243	3	1	93	1	0	0	0	0	1	0	0	0	4580	942	33	2	2832	2	DLG5	10	79581243	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3725759	79581243	55953504	133	18048											
ENTPD1	953	broad.mit.edu	37	chr10	97607402	97607402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcttcaacaccagttactGcccttactcccagtgtgcct	7	12	6	16	0	2	0	1	0	1	0	3	0	3	0	4	0	5	2	4	0	3	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:97607402G>A	uc001klh.3	+	7	1337	c.1013G>A	c.(1012-1014)TGC>TAC	p.C338Y	ENTPD1_uc001kli.3_Missense_Mutation_p.C345Y|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Missense_Mutation_p.C350Y|ENTPD1_uc010qok.1_Missense_Mutation_p.C230Y|ENTPD1_uc010qol.1_Missense_Mutation_p.C230Y|ENTPD1_uc010qom.1_Missense_Mutation_p.C297Y|ENTPD1_uc010qon.1_Missense_Mutation_p.C200Y|ENTPD1_uc009xva.2_Missense_Mutation_p.C200Y|ENTPD1_uc009xuz.2_RNA	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	338	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		ACCAGTTACTGCCCTTACTCC	0.418													11	132					0	0	0	0	A	97607402	A	A	97607402	3	1	93	1	0	0	0	0	1	0	0	0	5162	1319	46	4	1136	4	ENTPD1	10	97607402	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	18026159	97607402	37927345	134	18049											
PKD2L1	9033	broad.mit.edu	37	chr10	102054860	102054860	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgggtcatggttttgttGaagctgatgtacttgaatat	9	16	12	4	0	1	3	1	3	0	0	1	3	1	3	0	2	3	5	0	2	4	6			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:102054860G>A	uc001kqx.1	-	8	1760	c.1377C>T	c.(1375-1377)TTC>TTT	p.F459F	PKD2L1_uc009xwm.1_Silent_p.F412F	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	459	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TGGTTTTGTTGAAGCTGATGT	0.502													26	140					0	0	0	0	A	102054860	A	A	102054860	2	1	93	1	0	0	0	0	0	0	0	1	12022	1281	45	2		2	PKD2L1	10	102054860	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	4447458	102054860	33479887	135	18050											
GSTO1	9446	broad.mit.edu	37	chr10	106014946	106014946	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgcccccggggccggtcccGgagggctcgatccgcatcta	4	5	15	17	6	1	0	0	0	1	0	4	2	3	1	5	5	0	2	5	5	1	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:106014946G>A	uc001kya.2	+	2	69	c.60G>A	c.(58-60)CCG>CCA	p.P20P		NM_004832	NP_004823	P78417	GSTO1_HUMAN	glutathione-S-transferase omega 1	20					xenobiotic metabolic process	cytosol	glutathione transferase activity|monodehydroascorbate reductase (NADH) activity				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;8.07e-10)|all cancers(201;2.72e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0147)	Glutathione(DB00143)	GGCCGGTCCCGGAGGGCTCGA	0.687													18	46					0	0	0	0	A	106014946	A	A	106014946	2	1	93	1	0	0	0	0	0	0	0	1	6881	1103	39	1		1	GSTO1	10	106014946	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3960086	106014946	29519801	136	18051											
ZRANB1	54764	broad.mit.edu	37	chr10	126660540	126660540	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttttgtatttaaggtgtctCaacaagcagcaaagtgtatt	12	15	8	6	0	1	0	1	0	1	0	2	0	1	0	0	1	3	4	0	1	6	7			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:126660540C>G	uc001lic.2	+	3	1380	c.1009C>G	c.(1009-1011)CAA>GAA	p.Q337E	ZRANB1_uc010qug.1_Missense_Mutation_p.Q363E	NM_017580	NP_060050	Q9UGI0	ZRAN1_HUMAN	zinc finger, RAN-binding domain containing 1	337					positive regulation of Wnt receptor signaling pathway|protein K63-linked deubiquitination|Wnt receptor signaling pathway	aggresome|centrosome|intermediate filament cytoskeleton|nucleolus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.172)		Colorectal(40;0.113)|COAD - Colon adenocarcinoma(40;0.119)		TAAGGTGTCTCAACAAGCAGC	0.393													11	77					0	0	0	0	G	126660540	G	G	126660540	3	3	93	1	0	0	0	0	1	0	0	0	18289	827	29	2	1019	2	ZRANB1	10	126660540	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	20645594	126660540	8874207	137	18052											
CTBP2	1488	broad.mit.edu	37	chr10	126682516	126682516	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctttctcgtccaccaggccGccacgggctgcgttcacaag	6	8	11	16	4	2	0	1	0	1	0	4	0	3	0	4	2	1	3	4	2	1	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr10:126682516G>A	uc009yak.2	-	8	1106	c.819C>T	c.(817-819)GGC>GGT	p.G273G	CTBP2_uc009yal.2_Silent_p.G273G|CTBP2_uc001lif.3_Silent_p.G273G|CTBP2_uc001lih.3_Silent_p.G273G|CTBP2_uc001lid.3_Silent_p.G341G|CTBP2_uc001lie.3_Silent_p.G813G	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	273					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CCACCAGGCCGCCACGGGCTG	0.582													4	125					0	0	0	0	A	126682516	A	A	126682516	2	1	93	1	0	0	0	0	0	0	0	1	4015	1074	38	1		1	CTBP2	10	126682516	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	21976	126682516	8852231	138	18053											
PKP3	11187	broad.mit.edu	37	chr11	399093	399093	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccatgcgcaacctcatctaCgacaacgctgacaacaagct	13	6	7	15	3	2	1	1	1	1	0	2	2	2	1	2	0	6	3	2	0	5	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:399093C>G	uc001lpc.2	+	5	1246	c.1170C>G	c.(1168-1170)TAC>TAG	p.Y390*		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	390	ARM 2.				cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACCTCATCTACGACAACGCTG	0.597													15	37					0	0	0	0	G	399093	G	G	399093	4	3	93	1	0	0	0	0	0	1	0	0	12041	547	19	3	1188	3	PKP3	11	399093	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		399093	134607423	139	18054											
UBQLN3	50613	broad.mit.edu	37	chr11	5529406	5529406	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atggctgccgtgggggaaaaAgataagggagcaaatggaac	15	5	16	5	1	0	1	0	0	0	1	0	4	0	4	1	5	3	2	1	5	5	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:5529406A>G	uc001may.1	-	2	1469	c.1383T>C	c.(1381-1383)TCT>TCC	p.S461S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	461										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGGGGAAAAAGATAAGGGAG	0.547													9	53					0	0	0	0	G	5529406	G	G	5529406	2	3	93	1	0	0	0	0	0	0	0	1	16966	59	3	5		5	UBQLN3	11	5529406	Silent	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	5130313	5529406	129477110	140	18055											
SOX6	55553	broad.mit.edu	37	chr11	16007886	16007886	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttatagtttgggtacttctCtaagtggatcttgcttagcc	7	18	9	7	0	2	0	0	0	2	0	3	1	2	1	1	2	3	3	1	2	5	9			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:16007886C>T	uc001mme.2	-	15	2119	c.2086G>A	c.(2086-2088)GAG>AAG	p.E696K	SOX6_uc001mmd.2_Missense_Mutation_p.E659K|SOX6_uc001mmf.2_Missense_Mutation_p.E656K|SOX6_uc001mmg.2_Missense_Mutation_p.E663K	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	683	HMG box.				muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						GGGTACTTCTCTAAGTGGATC	0.443													49	122					0	0	0	0	T	16007886	T	T	16007886	3	4	93	1	0	0	0	0	1	0	0	0	15019	922	32	2	447	2	SOX6	11	16007886	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	10478480	16007886	118998630	141	18056											
DGKZ	8525	broad.mit.edu	37	chr11	46394220	46394220	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcctggcgtgcgggggcgAcggcacggtgagctccccgc	4	5	18	14	6	0	1	0	1	0	0	2	3	2	1	3	5	2	2	3	5	0	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:46394220A>G	uc001ncn.1	+	13	1753	c.1628A>G	c.(1627-1629)GAC>GGC	p.D543G	DGKZ_uc001nch.1_Missense_Mutation_p.D371G|DGKZ_uc010rgq.1_Missense_Mutation_p.D298G|DGKZ_uc001ncj.1_Missense_Mutation_p.D321G|DGKZ_uc010rgr.1_Missense_Mutation_p.D320G|DGKZ_uc001nck.1_Missense_Mutation_p.D133G|DGKZ_uc001ncl.2_Missense_Mutation_p.D355G|DGKZ_uc001ncm.2_Missense_Mutation_p.D354G|DGKZ_uc009yky.1_Missense_Mutation_p.D355G|DGKZ_uc010rgs.1_Missense_Mutation_p.D332G	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	543	DAGKc.|Mediates interaction with RASGRP1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TGCGGGGGCGACGGCACGGTG	0.662													13	24					0	0	0	0	G	46394220	G	G	46394220	3	3	93	1	0	0	0	0	1	0	0	0	4496	275	10	5	2121	5	DGKZ	11	46394220	Missense_Mutation	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	30386334	46394220	88612296	142	18057											
AGBL2	79841	broad.mit.edu	37	chr11	47698947	47698947	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttaagctctgctagacactGagtgaactatgaaagtgaaa	15	10	9	7	0	1	5	0	4	1	1	1	5	1	5	0	0	3	2	0	0	6	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:47698947G>C	uc001ngg.2	-	13	2123	c.2023C>G	c.(2023-2025)CAG>GAG	p.Q675E	AGBL2_uc001ngf.2_RNA|AGBL2_uc010rhq.1_Missense_Mutation_p.Q637E|AGBL2_uc001ngh.1_Intron	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic	675					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						GCTAGACACTGAGTGAACTAT	0.254													6	34					0	0	0	0	C	47698947	C	C	47698947	3	2	93	1	0	0	0	0	1	0	0	0	376	1299	45	2	709	2	AGBL2	11	47698947	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1304727	47698947	87307569	143	18058											
FOLH1	2346	broad.mit.edu	37	chr11	49186311	49186311	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcggtgtacaatcaactctCagagtgtagtttcctgaaaa	13	11	9	8	1	2	2	2	1	1	1	4	2	3	2	1	1	3	3	1	1	6	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:49186311C>T	uc001ngy.2	-	13	1647	c.1386G>A	c.(1384-1386)CTG>CTA	p.L462L	FOLH1_uc001ngz.2_Silent_p.L462L|FOLH1_uc009yly.2_Silent_p.L447L|FOLH1_uc009ylz.2_Silent_p.L447L|FOLH1_uc009yma.2_Silent_p.L154L	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	462	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AATCAACTCTCAGAGTGTAGT	0.279													8	24					0	0	0	0	T	49186311	T	T	49186311	2	4	93	1	0	0	0	0	0	0	0	1	6011	813	29	2		2	FOLH1	11	49186311	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	1487364	49186311	85820205	144	18059											
OR4A5	81318	broad.mit.edu	37	chr11	51411717	51411717	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctttacccctcttttcctGactgtaagttttaagggagc	7	15	9	10	0	1	1	0	1	1	0	2	2	2	2	3	2	2	3	3	2	3	7			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:51411717G>A	uc001nhi.1	-	1	679	c.679C>T	c.(679-681)CAG>TAG	p.Q227*		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				CTCTTTTCCTGACTGTAAGTT	0.423													8	88					0	0	0	0	A	51411717	A	A	51411717	4	1	93	1	0	0	0	0	0	1	0	0	11097	1299	45	2	272	2	OR4A5	11	51411717	Nonsense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	2225406	51411717	83594799	145	18060											
GPR44	11251	broad.mit.edu	37	chr11	60620857	60620857	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagccgctggcgaacatgttGagaaagaagatggaggagtg	14	6	16	5	2	0	3	0	1	0	3	0	7	0	5	1	3	2	2	1	3	4	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:60620857G>C	uc001nqc.2	-	2	451	c.339C>G	c.(337-339)CTC>CTG	p.L113L		NM_004778	NP_004769	Q9Y5Y4	GPR44_HUMAN	G protein-coupled receptor 44	113	Helical; Name=3; (Potential).				immune response	integral to plasma membrane	N-formyl peptide receptor activity			ovary(1)	1						CGAACATGTTGAGAAAGAAGA	0.642													3	9					0	0	0	0	C	60620857	C	C	60620857	2	2	93	1	0	0	0	0	0	0	0	1	6733	1277	45	2		2	GPR44	11	60620857	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	9209140	60620857	74385659	146	18061											
INCENP	3619	broad.mit.edu	37	chr11	61906207	61906207	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgagcagaaggaaccccccGaggaggctgagcctgtggcg	9	4	16	12	2	0	3	0	2	0	1	0	6	0	5	4	4	3	2	4	4	2	0	rs140202170		TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:61906207G>A	uc001nsw.1	+	6	1340	c.1138G>A	c.(1138-1140)GAG>AAG	p.E380K	INCENP_uc009ynw.1_Missense_Mutation_p.E380K|INCENP_uc001nsx.1_Missense_Mutation_p.E380K	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	380					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						GGAACCCCCCGAGGAGGCTGA	0.632													13	47					0	0	0	0	A	61906207	A	A	61906207	3	1	93	1	0	0	0	0	1	0	0	0	7772	1059	37	1	1156	1	INCENP	11	61906207	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1285350	61906207	73100309	147	18062											
OTUB1	55611	broad.mit.edu	37	chr11	63764101	63764101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttggaggcactgctggatGacagcaaggagttgcagcgg	10	7	16	8	1	0	1	0	1	0	0	0	4	0	4	0	5	4	5	0	5	1	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:63764101G>A	uc001nyf.1	+	4	923	c.319G>A	c.(319-321)GAC>AAC	p.D107N	OTUB1_uc001nyg.1_Missense_Mutation_p.M80I|OTUB1_uc010rmz.1_Missense_Mutation_p.D144N|OTUB1_uc010rna.1_Missense_Mutation_p.M46I|OTUB1_uc009ypa.2_Intron|OTUB1_uc009ypb.1_Missense_Mutation_p.D77N	NM_017670	NP_060140	Q96FW1	OTUB1_HUMAN	otubain 1	107	OTU.				protein K48-linked deubiquitination	cytoplasm	NEDD8-specific protease activity|omega peptidase activity|ubiquitin binding|ubiquitin-specific protease activity			breast(1)	1						ACTGCTGGATGACAGCAAGGA	0.592													17	56					0	0	0	0	A	63764101	A	A	63764101	3	1	93	1	0	0	0	0	1	0	0	0	11365	1290	45	2	333	2	OTUB1	11	63764101	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1857894	63764101	71242415	148	18063											
PACS1	55690	broad.mit.edu	37	chr11	66009032	66009032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcaagagtgtcttccgctCagtgcaggtgtcccgcctgc	5	10	11	15	2	3	1	2	0	1	1	5	1	5	1	4	1	2	2	4	1	1	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:66009032C>T	uc001oha.1	+	22	2698	c.2564C>T	c.(2563-2565)TCA>TTA	p.S855L	PACS1_uc010rou.1_Missense_Mutation_p.S391L	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	855					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						GTCTTCCGCTCAGTGCAGGTG	0.602													13	74					0	0	0	0	T	66009032	T	T	66009032	3	4	93	1	0	0	0	0	1	0	0	0	11426	838	29	2	2650	2	PACS1	11	66009032	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	2244931	66009032	68997484	149	18064											
PITPNM1	9600	broad.mit.edu	37	chr11	67271646	67271646	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatgtggtattccttgatGagcatcctgaaggcgctcgg	9	11	13	8	2	0	4	0	3	0	1	3	4	2	4	2	3	1	3	2	3	3	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:67271646G>T	uc001olx.2	-	1	195	c.6C>A	c.(4-6)CTC>CTA	p.L2L	PITPNM1_uc001oly.2_Silent_p.L2L|PITPNM1_uc001olz.2_Silent_p.L2L	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	2					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						ATTCCTTGATGAGCATCCTGA	0.706													7	35					1.76689e-08	1.88226e-08	1	0	T	67271646	T	T	67271646	2	4	93	1	0	0	0	0	0	0	0	1	12005	1277	45	2		2	PITPNM1	11	67271646	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1262614	67271646	67734870	150	18065											
TCIRG1	10312	broad.mit.edu	37	chr11	67818101	67818101	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggtgatggagggactctCagccttcctgcacgccctgc	5	9	13	14	1	1	1	1	1	1	0	3	3	2	3	3	3	3	2	3	3	0	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:67818101C>A	uc001one.2	+	19	2492	c.2384C>A	c.(2383-2385)TCA>TAA	p.S795*	TCIRG1_uc001ong.2_Nonsense_Mutation_p.S579*|TCIRG1_uc001onh.2_Nonsense_Mutation_p.S497*|TCIRG1_uc001oni.2_Nonsense_Mutation_p.S299*|TCIRG1_uc009ysd.2_Intron	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	795	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						GAGGGACTCTCAGCCTTCCTG	0.662													31	99					8.73648e-17	9.5363e-17	1	0	A	67818101	A	A	67818101	4	1	93	1	0	0	0	0	0	1	0	0	15769	838	29	2	2454	2	TCIRG1	11	67818101	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	546455	67818101	67188415	151	18066											
LRP5	4041	broad.mit.edu	37	chr11	68197131	68197131	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccacggtgctcatgcccagtCcacctcgtgctcctgcagaa	7	8	9	17	2	1	1	1	0	0	1	4	1	3	1	5	1	4	3	5	1	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:68197131C>G	uc001ont.2	+	17	3801	c.3726C>G	c.(3724-3726)GTC>GTG	p.V1242V	LRP5_uc009ysg.2_Silent_p.V652V	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1242	EGF-like 4.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CATGCCCAGTCCACCTCGTGC	0.582													16	101					0	0	0	0	G	68197131	G	G	68197131	2	3	93	1	0	0	0	0	0	0	0	1	9010	842	30	2		2	LRP5	11	68197131	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	379030	68197131	66809385	152	18067											
ARHGEF17	9828	broad.mit.edu	37	chr11	73068155	73068155	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctgaagcgaaagtcaggctCcctgcggcgcagctccatga	9	7	12	13	3	2	2	1	2	1	0	4	3	4	2	2	2	3	3	2	2	2	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:73068155C>T	uc001otu.2	+	8	3998	c.3977C>T	c.(3976-3978)TCC>TTC	p.S1326F		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1326					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						AAGTCAGGCTCCCTGCGGCGC	0.632													10	87					0	0	0	0	T	73068155	T	T	73068155	3	4	93	1	0	0	0	0	1	0	0	0	900	855	30	2	4007	2	ARHGEF17	11	73068155	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	4871024	73068155	61938361	153	18068											
TSKU	25987	broad.mit.edu	37	chr11	76507546	76507546	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaacctggtgcccctgcctGaggcgctgctcctccacctc	4	8	9	20	1	0	1	0	1	0	0	3	1	2	1	8	2	4	2	8	2	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:76507546G>A	uc001oxt.2	+	2	1058	c.886G>A	c.(886-888)GAG>AAG	p.E296K		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	296	LRR 10.					extracellular region					0	Ovarian(111;0.112)					GCCCCTGCCTGAGGCGCTGCT	0.692													5	56					0	0	0	0	A	76507546	A	A	76507546	3	1	93	1	0	0	0	0	1	0	0	0	16694	1291	45	2	888	2	TSKU	11	76507546	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3439391	76507546	58498970	154	18069											
NAALAD2	10003	broad.mit.edu	37	chr11	89891330	89891330	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagaatacactttcagacttGatgttgaagaaggagtggga	14	11	12	4	0	1	5	1	2	0	3	1	7	1	7	0	2	1	1	0	2	5	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:89891330G>C	uc001pdf.3	+	7	923	c.814G>C	c.(814-816)GAT>CAT	p.D272H	NAALAD2_uc009yvx.2_Missense_Mutation_p.D272H|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pdd.2_Missense_Mutation_p.D272H|NAALAD2_uc001pde.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	272	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TTTCAGACTTGATGTTGAAGA	0.244													55	168					0	0	0	0	C	89891330	C	C	89891330	3	2	93	1	0	0	0	0	1	0	0	0	10181	1290	45	2	840	2	NAALAD2	11	89891330	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	13383784	89891330	45115186	155	18070											
ZW10	9183	broad.mit.edu	37	chr11	113614714	113614714	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacttccagtttgttatcctCatcaggagtgggtaactctg	8	15	9	9	0	3	0	2	0	1	0	5	1	5	1	2	2	2	3	2	2	3	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:113614714C>T	uc001poe.2	-	10	1358	c.1321G>A	c.(1321-1323)GAG>AAG	p.E441K	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	441					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TTGTTATCCTCATCAGGAGTG	0.333													15	47					0	0	0	0	T	113614714	T	T	113614714	3	4	93	1	0	0	0	0	1	0	0	0	18314	835	29	2	1046	2	ZW10	11	113614714	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	23723384	113614714	21391802	156	18071											
ZNF259	8882	broad.mit.edu	37	chr11	116649676	116649676	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggcctgcctcatagccctCtgtcttcatgtcattgagcc	6	12	8	15	0	5	1	3	1	2	0	5	1	5	1	4	1	3	0	4	1	1	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:116649676C>G	uc001ppp.2	-	14	1378	c.1345G>C	c.(1345-1347)GAG>CAG	p.E449Q	ZNF259_uc009yzd.2_Missense_Mutation_p.E420Q|ZNF259_uc001ppq.2_Missense_Mutation_p.E379Q	NM_003904	NP_003895	O75312	ZPR1_HUMAN	zinc finger protein 259	449					cell proliferation|signal transduction	cytoplasm|nucleolus					0	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		TCATAGCCCTCTGTCTTCATG	0.522													17	61					0	0	0	0	G	116649676	G	G	116649676	3	3	93	1	0	0	0	0	1	0	0	0	17868	922	32	2	38	2	ZNF259	11	116649676	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	3034962	116649676	18356840	157	18072											
BACE1	23621	broad.mit.edu	37	chr11	117186311	117186311	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctgccccgacttgcccctCaggttgtccaccatctccac	5	9	6	21	1	2	0	1	0	1	0	4	1	3	0	8	1	2	1	8	1	0	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:117186311C>G	uc001pqz.2	-	1	662	c.201G>C	c.(199-201)CTG>CTC	p.L67L	BACE1_uc001pqw.2_Silent_p.L67L|BACE1_uc001pqx.2_Silent_p.L67L|BACE1_uc001pqy.2_Silent_p.L67L|BACE1_uc001pra.1_Silent_p.L67L	NM_012104	NP_036236	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1 isoform A	67	Extracellular (Potential).				beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			ovary(1)	1	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		ACTTGCCCCTCAGGTTGTCCA	0.711													8	42					0	0	0	0	G	117186311	G	G	117186311	2	3	93	1	0	0	0	0	0	0	0	1	1283	813	29	2		2	BACE1	11	117186311	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	536635	117186311	17820205	158	18073											
MPZL3	196264	broad.mit.edu	37	chr11	118111030	118111030	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatttcaacttgatcttttCtccaacataacctcggacat	11	14	4	12	1	3	1	1	1	2	0	5	2	3	2	2	1	3	1	2	1	3	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:118111030C>T	uc001psm.2	-	2	138	c.136G>A	c.(136-138)GAA>AAA	p.E46K	MPZL3_uc010rxy.1_Missense_Mutation_p.E34K|MPZL3_uc010rxz.1_RNA|MPZL3_uc009yzy.2_Intron	NM_198275	NP_938016	Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3 precursor	46	Ig-like V-type.				cell adhesion	integral to membrane					0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TTGATCTTTTCTCCAACATAA	0.418													14	66					0	0	0	0	T	118111030	T	T	118111030	3	4	93	1	0	0	0	0	1	0	0	0	9804	922	32	2	591	2	MPZL3	11	118111030	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	924719	118111030	16895486	159	18074											
SORL1	6653	broad.mit.edu	37	chr11	121478812	121478812	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcaccctctgatttgaaaaGgtggctgcggtgactagtcg	8	12	12	9	2	2	3	1	3	1	0	3	3	2	3	1	3	1	1	1	3	3	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr11:121478812G>A	uc001pxx.2	+	38	5247	c.5167_splice	c.e38-1	p.V1723_splice	SORL1_uc010rzp.1_Splice_Site_p.V569_splice|SORL1_uc010rzq.1_Splice_Site_p.V338_splice	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class						cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GATTTGAAAAGGTGGCTGCGG	0.393													26	21					0	0	0	0	A	121478812	A	A	121478812	5	1	93	1	0	0	0	0	0	0	1	0	14998	1014	35	4	5316	4	SORL1	11	121478812	Splice_Site	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	3367782	121478812	13527704	160	18075											
SLC2A14	144195	broad.mit.edu	37	chr12	7981428	7981428	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaatagcaccggccatagcTcttcagacccaaggatgagt	12	8	9	12	1	2	2	1	1	1	1	2	3	2	3	3	2	2	2	3	2	4	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:7981428T>C	uc001qtk.2	-	11	1410	c.617A>G	c.(616-618)GAG>GGG	p.E206G	SLC2A14_uc001qtl.2_Missense_Mutation_p.E183G|SLC2A14_uc001qtm.2_Missense_Mutation_p.E183G|SLC2A14_uc010sgg.1_Missense_Mutation_p.E97G|SLC2A14_uc001qtn.2_Missense_Mutation_p.E206G|SLC2A14_uc001qto.2_Intron|SLC2A14_uc010sgh.1_Missense_Mutation_p.E221G	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	206	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		CGGCCATAGCTCTTCAGACCC	0.453													12	125					0	0	0	0	C	7981428	C	C	7981428	3	2	93	1	0	0	0	0	1	0	0	0	14607	1551	54	5	969	5	SLC2A14	12	7981428	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08		7981428	125870467	161	18076											
ADAMTS20	80070	broad.mit.edu	37	chr12	43944794	43944794	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaagcagtggcgcaggtccGagggccctgcgtcgctctcc	6	6	15	14	4	1	1	0	0	1	1	4	2	2	1	3	3	2	3	3	3	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:43944794G>A	uc010skx.1	-	2	371	c.371C>T	c.(370-372)TCG>TTG	p.S124L		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	124						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GCGCAGGTCCGAGGGCCCTGC	0.667													3	23					0	0	0	0	A	43944794	A	A	43944794	3	1	93	1	0	0	0	0	1	0	0	0	266	1059	37	1	5512	1	ADAMTS20	12	43944794	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	35963366	43944794	89907101	162	18077											
PFKM	5213	broad.mit.edu	37	chr12	48526696	48526696	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtgcaaggactttcgggaaCgagaaggacgactccgagct	11	6	15	9	4	0	1	0	0	0	1	2	7	1	4	1	4	3	2	1	4	3	1	rs121918195		TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:48526696C>T	uc001rrc.2	+	5	453	c.283C>T	c.(283-285)CGA>TGA	p.R95*	PFKM_uc001rra.1_Translation_Start_Site|PFKM_uc001rrb.1_Nonsense_Mutation_p.R166*|PFKM_uc001rrd.2_Translation_Start_Site|PFKM_uc001rre.1_Nonsense_Mutation_p.R95*|PFKM_uc001rrg.1_Nonsense_Mutation_p.R95*	NM_000289	NP_000280	P08237	K6PF_HUMAN	phosphofructokinase, muscle	95					fructose 6-phosphate metabolic process|glycolysis|muscle cell homeostasis	6-phosphofructokinase complex|apical plasma membrane	6-phosphofructokinase activity|ATP binding|identical protein binding|kinase binding|metal ion binding|protein C-terminus binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4						CTTTCGGGAACGAGAAGGACG	0.567													8	40					0	0	0	0	T	48526696	T	T	48526696	4	4	93	1	0	0	0	0	0	1	0	0	11820	528	19	1	518	1	PFKM	12	48526696	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	4581902	48526696	85325199	163	18078											
SMARCC2	6601	broad.mit.edu	37	chr12	56565655	56565655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagaaaatgcaagatgcactCgtcctgtgtgcggcttccca	11	9	10	11	2	0	2	0	0	0	2	3	2	2	2	2	1	3	3	2	1	4	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:56565655C>T	uc001skb.2	-	20	2006	c.1900G>A	c.(1900-1902)GAG>AAG	p.E634K	SMARCC2_uc001skd.2_Missense_Mutation_p.E665K|SMARCC2_uc001ska.2_Missense_Mutation_p.E665K|SMARCC2_uc001skc.2_Missense_Mutation_p.E664K|SMARCC2_uc010sqf.1_Missense_Mutation_p.E554K	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	634	SANT.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			AAGATGCACTCGTCCTGTGTG	0.542													7	81					0	0	0	0	T	56565655	T	T	56565655	3	4	93	1	0	0	0	0	1	0	0	0	14840	893	31	1	1780	1	SMARCC2	12	56565655	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	8038959	56565655	77286240	164	18079											
STAC3	246329	broad.mit.edu	37	chr12	57642941	57642941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgggggtggctcctcctcctCctcttcttcctcttcctctt	0	17	7	17	0	4	0	0	0	4	0	10	0	10	0	6	3	0	1	6	3	0	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:57642941C>G	uc001snp.2	-	3	412	c.217G>C	c.(217-219)GAG>CAG	p.E73Q	STAC3_uc009zpl.2_Intron|STAC3_uc001snq.2_Missense_Mutation_p.E34Q|STAC3_uc010srm.1_Intron	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	73	Poly-Glu.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						tcctcctcctcctcttcttcc	0.443													25	67					0	0	0	0	G	57642941	G	G	57642941	3	3	93	1	0	0	0	0	1	0	0	0	15307	864	30	2	917	2	STAC3	12	57642941	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	1077286	57642941	76208954	165	18080											
BBS10	79738	broad.mit.edu	37	chr12	76740945	76740945	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctgaatttagaataaactCtgatccagaagtggaaaaaa	18	11	7	5	0	2	4	0	2	2	2	3	5	3	5	1	1	1	0	1	1	9	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:76740945C>G	uc001syd.1	-	2	904	c.820G>C	c.(820-822)GAG>CAG	p.E274Q		NM_024685	NP_078961	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	274					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			ovary(1)|skin(1)	2						AGAATAAACTCTGATCCAGAA	0.368									Bardet-Biedl_syndrome				10	44					0	0	0	0	G	76740945	G	G	76740945	3	3	93	1	0	0	0	0	1	0	0	0	1338	922	32	2	1355	2	BBS10	12	76740945	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	19098004	76740945	57110950	166	18081											
PPFIA2	8499	broad.mit.edu	37	chr12	82147853	82147853	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggctttcctgggtctcccGaagggtgtctagaagacgat	8	10	14	9	2	2	2	0	0	2	2	4	5	3	2	2	3	0	1	2	3	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:82147853G>A	uc001szo.1	-	3	309	c.148C>T	c.(148-150)CGG>TGG	p.R50W	PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	309										ovary(3)|lung(2)|pancreas(1)	6						TGGGTCTCCCGAAGGGTGTCT	0.527													11	36					0	0	0	0	A	82147853	A	A	82147853	3	1	93	1	0	0	0	0	1	0	0	0	12365	1057	37	1	3745	1	PPFIA2	12	82147853	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	5406908	82147853	51704042	167	18082											
C12orf63	374467	broad.mit.edu	37	chr12	97136306	97136306	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attcatctgtggttgaggtgCcgcttagcattggtgactgc	6	14	13	8	1	2	2	1	2	1	0	2	2	2	2	1	3	3	3	1	3	1	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:97136306C>G	uc001tet.1	+	19	2514	c.2436C>G	c.(2434-2436)TGC>TGG	p.C812W		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	812										skin(6)|ovary(1)	7						GGTTGAGGTGCCGCTTAGCAT	0.343													7	39					0	0	0	0	G	97136306	G	G	97136306	3	3	93	1	0	0	0	0	1	0	0	0	1712	747	26	4	2506	4	C12orf63	12	97136306	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	14988453	97136306	36715589	168	18083											
TRPV4	59341	broad.mit.edu	37	chr12	110236715	110236715	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agccagcgacaggggcagctCccctgcgggccagggtgaag	8	3	17	13	2	0	1	0	1	0	0	1	2	1	1	4	4	4	2	4	4	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:110236715C>A	uc001tpj.1	-	5	951	c.856G>T	c.(856-858)GAG>TAG	p.E286*	TRPV4_uc001tpg.1_Nonsense_Mutation_p.E252*|TRPV4_uc001tph.1_Nonsense_Mutation_p.E239*|TRPV4_uc001tpi.1_Nonsense_Mutation_p.E239*|TRPV4_uc001tpk.1_Nonsense_Mutation_p.E286*|TRPV4_uc001tpl.1_Nonsense_Mutation_p.E286*	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	286	Cytoplasmic (Potential).|ANK 2.				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AGGGGCAGCTCCCCTGCGGGC	0.682													20	58					8.04996e-18	8.84924e-18	1	0	A	110236715	A	A	110236715	4	1	93	1	0	0	0	0	0	1	0	0	16665	864	30	2	1803	2	TRPV4	12	110236715	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	13100409	110236715	23615180	169	18084											
VPS33A	65082	broad.mit.edu	37	chr12	122748187	122748187	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaaaaaaattatattcttCacatcagctgccggcaaacg	17	9	5	10	2	3	0	2	0	1	0	3	0	3	0	1	1	3	2	1	1	7	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:122748187C>T	uc001ucd.2	-	3	341	c.228G>A	c.(226-228)GTG>GTA	p.V76V	VPS33A_uc001ucc.2_RNA|VPS33A_uc001uce.2_Silent_p.V76V	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	76					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		TTATATTCTTCACATCAGCTG	0.388													10	72					0	0	0	0	T	122748187	T	T	122748187	2	4	93	1	0	0	0	0	0	0	0	1	17269	813	29	2		2	VPS33A	12	122748187	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	12511472	122748187	11103708	170	18085											
ABCB9	23457	broad.mit.edu	37	chr12	123444339	123444339	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcggtggccgcccctggCtccagggcctgggtgcctgg	1	7	17	16	2	0	0	0	0	0	0	2	0	1	0	7	6	1	1	7	6	0	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:123444339C>T	uc001udm.3	-	2	754	c.444G>A	c.(442-444)GAG>GAA	p.E148E	ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Silent_p.E148E|ABCB9_uc010taj.1_Silent_p.E148E|ABCB9_uc001udp.2_Silent_p.E148E|ABCB9_uc001udq.2_5'UTR|ABCB9_uc001udr.2_Silent_p.E148E	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	148					positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		CCGCCCCTGGCTCCAGGGCCT	0.692													9	28					0	0	0	0	T	123444339	T	T	123444339	2	4	93	1	0	0	0	0	0	0	0	1	48	796	28	4		4	ABCB9	12	123444339	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	696152	123444339	10407556	171	18086											
GPR133	283383	broad.mit.edu	37	chr12	131593290	131593290	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccctgccaagtgatggccGtgctcctacactacttcttc	6	11	7	17	1	1	1	0	1	1	0	3	1	2	1	5	1	4	1	5	1	3	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr12:131593290G>A	uc001uit.3	+	18	2468	c.1909G>A	c.(1909-1911)GTG>ATG	p.V637M	GPR133_uc010tbm.1_Missense_Mutation_p.V669M|GPR133_uc009zyo.2_Intron|GPR133_uc001uiv.1_Missense_Mutation_p.V156M|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	637	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		AGTGATGGCCGTGCTCCTACA	0.582													53	197					0	0	0	0	A	131593290	A	A	131593290	3	1	93	1	0	0	0	0	1	0	0	0	6681	1145	40	1	1979	1	GPR133	12	131593290	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	8148951	131593290	2258605	172	18087											
PCDH8	5100	broad.mit.edu	37	chr13	53418853	53418853	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctctgtgcagtactttctCatagacgctctgcagcccca	7	12	8	14	1	3	1	1	0	3	1	5	1	3	1	2	0	4	4	2	0	2	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr13:53418853C>G	uc001vhi.2	-	3	3258	c.3055G>C	c.(3055-3057)GAG>CAG	p.E1019Q	PCDH8_uc001vhj.2_Missense_Mutation_p.E922Q	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	1019	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		AGTACTTTCTCATAGACGCTC	0.577													31	98					0	0	0	0	G	53418853	G	G	53418853	3	3	93	1	0	0	0	0	1	0	0	0	11571	835	29	2	161	2	PCDH8	13	53418853	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		53418853	61751025	173	18088											
C13orf34	79866	broad.mit.edu	37	chr13	73320742	73320742	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttatatagatggctgctcGccaattaaaaattggtctcc	11	13	7	10	1	1	1	0	0	1	1	3	1	1	1	3	2	1	2	3	2	7	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr13:73320742G>A	uc001viv.1	+	10	1094	c.975G>A	c.(973-975)TCG>TCA	p.S325S	C13orf34_uc010thq.1_Silent_p.S100S|C13orf34_uc010aen.1_Silent_p.S400S|C13orf34_uc010thr.1_Silent_p.S255S|C13orf34_uc001viw.1_Silent_p.S274S	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	325					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		ATGGCTGCTCGCCAATTAAAA	0.393													22	102					0	0	0	0	A	73320742	A	A	73320742	2	1	93	1	0	0	0	0	0	0	0	1	1734	1074	38	1		1	C13orf34	13	73320742	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	19901889	73320742	41849136	174	18089											
RBM26	64062	broad.mit.edu	37	chr13	79940220	79940220	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagagagggtggagcaggagGaggctggtgatgaatgccag	12	5	20	4	0	0	3	0	2	0	1	0	7	0	6	1	6	2	2	1	6	2	0	rs143505765		TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr13:79940220G>A	uc001vkz.2	-	8	1260	c.1246C>T	c.(1246-1248)CCT>TCT	p.P416S	RBM26_uc001vky.2_Missense_Mutation_p.P416S|RBM26_uc001vla.2_Missense_Mutation_p.P416S|RBM26_uc001vkx.2_Missense_Mutation_p.P128S	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	416	Pro-rich.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GGAGCAGGAGGAGGCTGGTGA	0.438													27	131					0	0	0	0	A	79940220	A	A	79940220	3	1	93	1	0	0	0	0	1	0	0	0	13191	1174	41	2	1752	2	RBM26	13	79940220	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	6619478	79940220	35229658	175	18090											
C13orf16	121793	broad.mit.edu	37	chr13	111980540	111980540	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttttgcagtgtgtgacgtTcctctgtatgacatttgtga	6	17	11	7	1	1	3	0	3	1	0	2	3	2	3	1	0	1	4	1	0	1	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr13:111980540T>C	uc001vsa.2	+	3	198	c.69T>C	c.(67-69)GTT>GTC	p.V23V		NM_152324	NP_689537	Q8N6K0	CM016_HUMAN	hypothetical protein LOC121793	23	Extracellular (Potential).					integral to membrane					0	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		all cancers(43;0.113)|GBM - Glioblastoma multiforme(44;0.174)|BRCA - Breast invasive adenocarcinoma(86;0.188)			TGTGTGACGTTCCTCTGTATG	0.542													25	77					0	0	0	0	C	111980540	C	C	111980540	2	2	93	1	0	0	0	0	0	0	0	1	1725	1770	62	5		5	C13orf16	13	111980540	Silent	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	32040320	111980540	3189338	176	18091											
MDGA2	161357	broad.mit.edu	37	chr14	47566311	47566311	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taggatcatccaccaagagtTtaattgacggtgatgctaaa	14	11	9	7	1	1	3	1	2	0	1	2	4	2	4	2	2	1	2	2	2	5	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr14:47566311T>C	uc001wwj.3	-	6	930	c.734A>G	c.(733-735)AAA>AGA	p.K245R	MDGA2_uc001wwi.3_Missense_Mutation_p.K16R|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	245	Ig-like 3.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CACCAAGAGTTTAATTGACGG	0.403													51	83					0	0	0	0	C	47566311	C	C	47566311	3	2	93	1	0	0	0	0	1	0	0	0	9460	1841	64	5	2184	5	MDGA2	14	47566311	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08		47566311	59783229	177	18092											
OTX2	5015	broad.mit.edu	37	chr14	57268748	57268748	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcccccaaagtaggaagttGagccagcatatccttgacta	12	9	9	11	0	0	2	0	2	0	0	1	3	1	3	4	1	3	3	4	1	5	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr14:57268748G>A	uc001xcp.2	-	3	746	c.575C>T	c.(574-576)TCA>TTA	p.S192L	OTX2_uc010aou.2_Missense_Mutation_p.S192L|OTX2_uc001xcq.2_Missense_Mutation_p.S200L	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	192					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					GTAGGAAGTTGAGCCAGCATA	0.527													19	68					0	0	0	0	A	57268748	A	A	57268748	3	1	93	1	0	0	0	0	1	0	0	0	11375	1294	45	2	298	2	OTX2	14	57268748	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	9702437	57268748	50080792	178	18093											
NRXN3	9369	broad.mit.edu	37	chr14	80130178	80130178	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttgacatctccatcaaaGaggagagaacccctgtaaat	15	8	8	10	0	2	3	1	1	1	2	3	5	2	4	3	1	1	2	3	1	4	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr14:80130178G>T	uc001xun.2	+	14	2874	c.2383G>T	c.(2383-2385)GAG>TAG	p.E795*	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Nonsense_Mutation_p.E163*|NRXN3_uc010asw.2_Nonsense_Mutation_p.E163*|NRXN3_uc001xur.3_Nonsense_Mutation_p.E163*	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1168	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CTCCATCAAAGAGGAGAGAAC	0.478													8	40					0.000157383	0.000164272	1	0	T	80130178	T	T	80130178	4	4	93	1	0	0	0	0	0	1	0	0	10721	943	33	2	2680	2	NRXN3	14	80130178	Nonsense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	22861430	80130178	27219362	179	18094											
CATSPERB	79820	broad.mit.edu	37	chr14	92136190	92136190	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcatacaaaaagtggcttcGgggatgaaataccattccaa	16	8	9	8	1	0	1	0	1	0	0	2	2	1	2	2	3	3	2	2	3	6	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr14:92136190G>A	uc001xzs.1	-	14	1395	c.1255C>T	c.(1255-1257)CGA>TGA	p.R419*	CATSPERB_uc010aub.1_5'UTR	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	419					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				AAGTGGCTTCGGGGATGAAAT	0.413													15	35					0	0	0	0	A	92136190	A	A	92136190	4	1	93	1	0	0	0	0	0	1	0	0	2703	1124	39	1	2151	1	CATSPERB	14	92136190	Nonsense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	12006012	92136190	15213350	180	18095											
C15orf2	23742	broad.mit.edu	37	chr15	24923158	24923158	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcatcttgcagtctgcctCtgtctccaagaagtacctcc	7	13	7	14	0	5	1	1	0	4	1	7	1	6	1	4	0	3	2	4	0	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr15:24923158C>A	uc001ywo.2	+	1	2618	c.2144C>A	c.(2143-2145)TCT>TAT	p.S715Y		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	715					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CAGTCTGCCTCTGTCTCCAAG	0.522													41	130					4.44401e-20	4.92016e-20	1	0	A	24923158	A	A	24923158	3	1	93	1	0	0	0	0	1	0	0	0	1790	913	32	2	2146	2	C15orf2	15	24923158	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		24923158	77608234	181	18096											
TUBGCP4	27229	broad.mit.edu	37	chr15	43687329	43687329	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggaagttgatggtagaaGaatccgatttactgggtcag	11	12	13	5	1	2	3	1	1	1	2	3	5	3	4	1	3	1	2	1	3	5	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr15:43687329G>T	uc001zro.2	+	10	1279	c.1039G>T	c.(1039-1041)GAA>TAA	p.E347*	TUBGCP4_uc001zrn.2_Nonsense_Mutation_p.E347*|TUBGCP4_uc010bdh.2_RNA	NM_014444	NP_055259	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	347					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			ovary(3)	3		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		GATGGTAGAAGAATCCGATTT	0.413													36	160					4.62619e-21	5.1587e-21	1	0	T	43687329	T	T	43687329	4	4	93	1	0	0	0	0	0	1	0	0	16836	943	33	2	1077	2	TUBGCP4	15	43687329	Nonsense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	18764171	43687329	58844063	182	18097											
FSD2	123722	broad.mit.edu	37	chr15	83455869	83455869	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttctgggtatgttttcatCaacaaactcatcccctaatt	10	16	5	10	0	4	0	3	0	1	0	5	0	5	0	2	1	2	3	2	1	4	6			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr15:83455869C>G	uc002bjd.2	-	2	441	c.274G>C	c.(274-276)GAT>CAT	p.D92H	FSD2_uc010uol.1_Missense_Mutation_p.D92H|FSD2_uc010uom.1_Missense_Mutation_p.D92H	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	92										central_nervous_system(1)	1						ATGTTTTCATCAACAAACTCA	0.448													35	118					0	0	0	0	G	83455869	G	G	83455869	3	3	93	1	0	0	0	0	1	0	0	0	6105	826	29	2	2023	2	FSD2	15	83455869	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	39768540	83455869	19075523	183	18098											
FSD2	123722	broad.mit.edu	37	chr15	83455949	83455949	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacttcctcttgaaggtctCtttgagccttaccatcccct	6	14	5	16	0	2	2	0	2	2	0	5	2	4	2	6	1	2	0	6	1	2	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr15:83455949C>G	uc002bjd.2	-	2	361	c.194G>C	c.(193-195)AGA>ACA	p.R65T	FSD2_uc010uol.1_Missense_Mutation_p.R65T|FSD2_uc010uom.1_Missense_Mutation_p.R65T	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	65										central_nervous_system(1)	1						TTGAAGGTCTCTTTGAGCCTT	0.438													44	127					0	0	0	0	G	83455949	G	G	83455949	3	3	93	1	0	0	0	0	1	0	0	0	6105	913	32	2	2103	2	FSD2	15	83455949	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	80	83455949	19075443	184	18099											
FES	2242	broad.mit.edu	37	chr15	91428286	91428286	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacagcactatgggcttctCttccgagctgtgcagccccc	7	9	10	15	1	1	0	0	0	1	0	3	2	2	0	3	1	5	4	3	1	2	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr15:91428286C>T	uc002bpv.2	+	2	107	c.11C>T	c.(10-12)TCT>TTT	p.S4F	FES_uc010uqj.1_Missense_Mutation_p.S4F|FES_uc010uqk.1_Missense_Mutation_p.S4F|FES_uc002bpw.2_RNA|FES_uc010bny.2_Missense_Mutation_p.S4F|FES_uc002bpx.2_Missense_Mutation_p.S4F|FES_uc002bpy.2_Missense_Mutation_p.S4F	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	4	FCH.|Important for interaction with membranes containing phosphoinositides.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			ATGGGCTTCTCTTCCGAGCTG	0.632													56	206					0	0	0	0	T	91428286	T	T	91428286	3	4	93	1	0	0	0	0	1	0	0	0	5852	913	32	2	13	2	FES	15	91428286	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	7972337	91428286	11103106	185	18100											
WDR90	197335	broad.mit.edu	37	chr16	716348	716348	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatctgtgtcacgtgcaaaGaggtaaagcagccccaagag	13	6	11	11	1	2	2	1	0	1	2	2	2	2	2	3	1	3	3	3	1	4	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:716348G>C	uc002cii.1	+	37	4792	c.4738G>C	c.(4738-4740)GAG>CAG	p.E1580Q	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Missense_Mutation_p.E195Q|WDR90_uc010uul.1_Missense_Mutation_p.E179Q|WDR90_uc002cio.1_Missense_Mutation_p.E179Q|WDR90_uc010bqx.1_Missense_Mutation_p.E179Q|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1580	WD 20.									ovary(1)	1		Hepatocellular(780;0.0218)				CACGTGCAAAGAGGTAAAGCA	0.637													13	118					0	0	0	0	C	716348	C	C	716348	3	2	93	1	0	0	0	0	1	0	0	0	17405	943	33	2	4884	2	WDR90	16	716348	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08		716348	89638405	186	18101											
C16orf42	115939	broad.mit.edu	37	chr16	1399476	1399476	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgattcctttccaaacctCagccggggccctggcctcag	6	10	9	16	1	2	1	2	1	0	0	4	1	4	1	6	3	2	0	6	3	1	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:1399476C>A	uc002cll.2	-	6	969	c.901G>T	c.(901-903)GAG>TAG	p.E301*	GNPTG_uc002clm.2_5'Flank	NM_001001410	NP_001001410	Q9UJK0	TSR3_HUMAN	hypothetical protein LOC115939	301					rRNA processing						0		Hepatocellular(780;0.0893)				TTCCAAACCTCAGCCGGGGCC	0.597													133	404					1.02779e-63	1.15859e-63	1	0	A	1399476	A	A	1399476	4	1	93	1	0	0	0	0	0	1	0	0	1819	835	29	2	41	2	C16orf42	16	1399476	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	683128	1399476	88955277	187	18102											
IGFALS	3483	broad.mit.edu	37	chr16	1840972	1840972	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacgtccagccagaaggcccGctgcagggggcccagggcgt	7	3	17	14	3	0	1	0	0	0	1	1	2	1	1	4	4	2	2	4	4	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:1840972G>A	uc002cmy.2	-	2	1528	c.1447C>T	c.(1447-1449)CGG>TGG	p.R483W	IGFALS_uc010uvn.1_Missense_Mutation_p.R521W|IGFALS_uc010uvo.1_Missense_Mutation_p.R117W	NM_004970	NP_004961	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid	483	LRR 18.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding				0						CAGAAGGCCCGCTGCAGGGGG	0.697													12	24					0	0	0	0	A	1840972	A	A	1840972	3	1	93	1	0	0	0	0	1	0	0	0	7616	1086	38	1	374	1	IGFALS	16	1840972	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	441496	1840972	88513781	188	18103											
TBL3	10607	broad.mit.edu	37	chr16	2025598	2025598	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggcccagccgccgggccctGggcaggagctgacccactgc	6	3	15	17	2	0	1	0	1	0	0	0	2	0	2	5	4	3	2	5	4	0	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:2025598G>C	uc002cnu.1	+	10	976	c.874G>C	c.(874-876)GGG>CGG	p.G292R	TBL3_uc002cnv.1_Missense_Mutation_p.G178R|TBL3_uc010bsb.1_Missense_Mutation_p.G81R|TBL3_uc010bsc.1_Missense_Mutation_p.G178R|TBL3_uc010uvt.1_5'UTR|TBL3_uc002cnw.1_5'Flank	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	292	WD 6.				G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0						GCCGGGCCCTGGGCAGGAGCT	0.697													7	24					0	0	0	0	C	2025598	C	C	2025598	3	2	93	1	0	0	0	0	1	0	0	0	15709	1348	47	4	912	4	TBL3	16	2025598	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	184626	2025598	88329155	189	18104											
SRRM2	23524	broad.mit.edu	37	chr16	2812868	2812868	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctttgaggcgcagcctttCagggtcttccccatgcccta	5	12	10	14	1	3	1	1	1	2	0	4	1	4	1	4	2	2	1	4	2	1	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:2812868C>T	uc002crk.2	+	11	2888	c.2339C>T	c.(2338-2340)TCA>TTA	p.S780L	SRRM2_uc002crj.1_Missense_Mutation_p.S684L|SRRM2_uc002crl.1_Missense_Mutation_p.S780L|SRRM2_uc010bsu.1_Missense_Mutation_p.S684L	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	780	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CGCAGCCTTTCAGGGTCTTCC	0.517													69	337					0	0	0	0	T	2812868	T	T	2812868	3	4	93	1	0	0	0	0	1	0	0	0	15235	838	29	2	2377	2	SRRM2	16	2812868	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	787270	2812868	87541885	190	18105											
BTBD12	84464	broad.mit.edu	37	chr16	3632510	3632510	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctcagctctgcctgcagctCccgcagctcaaagggctggt	6	8	11	16	1	3	0	2	0	1	0	4	0	4	0	3	2	5	6	3	2	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:3632510C>T	uc002cvp.2	-	15	5965	c.5338G>A	c.(5338-5340)GAG>AAG	p.E1780K		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1780	Interaction with PLK1 and TERF2-TERF2IP.|Interaction with SLX1.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						GCCTGCAGCTCCCGCAGCTCA	0.647								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				30	136					0	0	0	0	T	3632510	T	T	3632510	3	4	93	1	0	0	0	0	1	0	0	0	1545	864	30	2	170	2	BTBD12	16	3632510	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	819642	3632510	86722243	191	18106											
TMEM186	25880	broad.mit.edu	37	chr16	8890280	8890280	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcatcaaaacggtaaaacatCcagaatttctcagtctctgc	14	10	6	11	1	3	1	2	0	2	1	6	1	4	1	1	1	3	2	1	1	5	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:8890280C>G	uc002cze.2	-	2	205	c.171G>C	c.(169-171)TGG>TGC	p.W57C	PMM2_uc002czf.3_5'Flank|PMM2_uc010uyf.1_5'Flank|PMM2_uc010uyg.1_5'Flank|PMM2_uc010uyh.1_5'Flank|PMM2_uc010buj.2_5'Flank|PMM2_uc010uyi.1_5'Flank|PMM2_uc010uye.1_5'Flank	NM_015421	NP_056236	Q96B77	TM186_HUMAN	transmembrane protein 186	57						integral to membrane|mitochondrion				ovary(1)	1						GGTAAAACATCCAGAATTTCT	0.522													26	209					0	0	0	0	G	8890280	G	G	8890280	3	3	93	1	0	0	0	0	1	0	0	0	16174	856	30	2	474	2	TMEM186	16	8890280	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	5257770	8890280	81464473	192	18107											
CPPED1	55313	broad.mit.edu	37	chr16	12758885	12758885	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtctctgcccagctggcatCcaatggcagatgacaccacc	9	7	10	15	0	1	2	0	1	1	1	3	2	2	2	4	3	2	3	4	3	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:12758885C>T	uc002dca.3	-	4	914	c.803G>A	c.(802-804)GGA>GAA	p.G268E	CPPED1_uc002dcb.3_Missense_Mutation_p.G126E|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	268							hydrolase activity|metal ion binding				0						CAGCTGGCATCCAATGGCAGA	0.562													7	86					0	0	0	0	T	12758885	T	T	12758885	3	4	93	1	0	0	0	0	1	0	0	0	3837	855	30	2	145	2	CPPED1	16	12758885	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	3868605	12758885	77595868	193	18108											
UMOD	7369	broad.mit.edu	37	chr16	20348623	20348623	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcaactcacaggcttgcacTtttcattcatggtgtcacag	9	13	8	11	0	5	0	5	0	0	0	5	0	5	0	0	2	2	2	0	2	1	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:20348623T>C	uc002dgz.2	-	8	1859	c.1730A>G	c.(1729-1731)AAG>AGG	p.K577R	UMOD_uc002dha.2_Missense_Mutation_p.K577R|UMOD_uc002dhb.2_Missense_Mutation_p.K610R	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	577	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						AGGCTTGCACTTTTCATTCAT	0.473													13	28					0	0	0	0	C	20348623	C	C	20348623	3	2	93	1	0	0	0	0	1	0	0	0	17047	1609	56	5	208	5	UMOD	16	20348623	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	7589738	20348623	70006130	194	18109											
IRX5	10265	broad.mit.edu	37	chr16	54966471	54966471	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtaccatccttacgcggCgcccctgggatcgtaccctt	5	9	12	15	4	0	0	0	0	0	0	2	1	1	1	5	4	3	2	5	4	3	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:54966471C>T	uc002ehv.2	+	2	311	c.311C>T	c.(310-312)GCG>GTG	p.A104V	IRX5_uc010cca.1_Missense_Mutation_p.A156V|IRX5_uc002ehw.2_Missense_Mutation_p.A38V	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	104					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						CCTTACGCGGCGCCCCTGGGA	0.662													14	49					0	0	0	0	T	54966471	T	T	54966471	3	4	93	1	0	0	0	0	1	0	0	0	7886	768	27	1	317	1	IRX5	16	54966471	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	34617848	54966471	35388282	195	18110											
CES1	1066	broad.mit.edu	37	chr16	55844472	55844472	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagatgggacaccaaacatCacatctgctatcaagtccag	15	7	7	12	0	3	1	2	0	1	1	4	2	4	2	2	1	2	1	2	1	3	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:55844472C>G	uc002eim.2	-	11	1380	c.1272G>C	c.(1270-1272)GTG>GTC	p.V424V	CES1_uc010ccf.2_Silent_p.V99V|CES1_uc002eil.2_Silent_p.V425V|CES1_uc002ein.2_Silent_p.V423V	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	424					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	CACCAAACATCACATCTGCTA	0.498													35	112					0	0	0	0	G	55844472	G	G	55844472	2	3	93	1	0	0	0	0	0	0	0	1	3284	813	29	2		2	CES1	16	55844472	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	878001	55844472	34510281	196	18111											
SF3B3	23450	broad.mit.edu	37	chr16	70597814	70597814	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaagctcggtgctgtcttcaAtcaagtagccttcccactgc	8	11	9	13	1	3	0	2	0	1	0	5	1	4	0	2	1	4	3	2	1	4	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:70597814A>G	uc002ezf.2	+	18	2535	c.2324A>G	c.(2323-2325)AAT>AGT	p.N775S		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	775					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				GCTGTCTTCAATCAAGTAGCC	0.428													38	85					0	0	0	0	G	70597814	G	G	70597814	3	3	93	1	0	0	0	0	1	0	0	0	14217	101	4	5	2390	5	SF3B3	16	70597814	Missense_Mutation	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	14753342	70597814	19756939	197	18112											
KARS	3735	broad.mit.edu	37	chr16	75674163	75674163	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgaagtcagtgagtgagaTgtctacatggaacttgtgtg	11	12	14	4	0	2	3	1	3	1	1	2	6	2	4	0	1	2	0	0	1	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr16:75674163T>A	uc002feq.2	-	3	355	c.307A>T	c.(307-309)ATC>TTC	p.I103F	KARS_uc002fer.2_Missense_Mutation_p.I131F|KARS_uc002fes.2_Intron|KARS_uc010cgz.2_5'UTR	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	103					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	GTGAGTGAGATGTCTACATGG	0.448													68	238					0	0	0	0	A	75674163	A	A	75674163	3	1	93	1	0	0	0	0	1	0	0	0	8019	1464	51	5	1534	5	KARS	16	75674163	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	5076349	75674163	14680590	198	18113											
RPA1	6117	broad.mit.edu	37	chr17	1787118	1787118	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttttcaggtttgacgcagaAggacaagccttagatggtgt	10	12	13	6	1	1	3	1	1	0	2	1	4	1	4	1	3	1	3	1	3	3	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:1787118A>G	uc002fto.2	+	13	1369	c.1254A>G	c.(1252-1254)GAA>GAG	p.E418E		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	418					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TTGACGCAGAAGGACAAGCCT	0.488								NER					40	124					0	0	0	0	G	1787118	G	G	1787118	2	3	93	1	0	0	0	0	0	0	0	1	13601	69	3	5		5	RPA1	17	1787118	Silent	SNP	A	TCGA-CQ-5326-01A-01D-1870-08		1787118	79408092	199	18114											
TRPV3	162514	broad.mit.edu	37	chr17	3436163	3436163	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgaggtgatgtccgtctgctCgtgctccatcagcagctgca	6	10	12	13	3	2	1	1	1	1	0	5	2	4	1	2	1	5	5	2	1	0	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:3436163C>T	uc002fvt.1	-	8	1175	c.853G>A	c.(853-855)GAG>AAG	p.E285K	TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Missense_Mutation_p.E269K|TRPV3_uc010vri.1_Missense_Mutation_p.E240K|TRPV3_uc010vrj.1_Missense_Mutation_p.E269K|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Missense_Mutation_p.E269K|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Missense_Mutation_p.E285K|TRPV3_uc002fvu.2_Missense_Mutation_p.E285K|TRPV3_uc010vrn.1_5'Flank	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	285	ANK 2.|Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	TCCGTCTGCTCGTGCTCCATC	0.602													11	20					0	0	0	0	T	3436163	T	T	3436163	3	4	93	1	0	0	0	0	1	0	0	0	16664	893	31	1	1563	1	TRPV3	17	3436163	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	1649045	3436163	77759047	200	18115											
TP53	7157	broad.mit.edu	37	chr17	7577534	7577534	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgatgatggtgaggatgggCctccggttcatgccgcccat	6	10	15	10	2	1	3	1	3	0	0	2	4	2	4	4	4	1	1	4	4	0	1	rs28934571		TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:7577534C>A	uc002gim.2	-	7	941	c.747G>T	c.(745-747)AGG>AGT	p.R249S	TP53_uc002gig.1_Missense_Mutation_p.R249S|TP53_uc002gih.2_Missense_Mutation_p.R249S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R117S|TP53_uc010cng.1_Missense_Mutation_p.R117S|TP53_uc002gii.1_Missense_Mutation_p.R117S|TP53_uc010cnh.1_Missense_Mutation_p.R249S|TP53_uc010cni.1_Missense_Mutation_p.R249S|TP53_uc002gij.2_Missense_Mutation_p.R249S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R156S|TP53_uc002gio.2_Missense_Mutation_p.R117S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	249	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> I (in a sporadic cancer; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249S(303)|p.R249M(25)|p.R249G(24)|p.R249W(23)|p.R249T(16)|p.R249K(14)|p.0?(7)|p.R249R(6)|p.R249fs*96(6)|p.M246_P250delMNRRP(2)|p.R249fs*14(2)|p.N247_P250delNRRP(1)|p.R249fs*19(1)|p.R249fs*15(1)|p.R249_I251delRPI(1)|p.R249_P250delRP(1)|p.R249_P250insR(1)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.R249_T256delRPILTIIT(1)|p.R249_P250>SS(1)|p.P250fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGAGGATGGGCCTCCGGTTCA	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	47					0.000422831	0.000439858	1	0	A	7577534	A	A	7577534	3	1	93	1	0	0	0	0	1	0	0	0	16448	738	26	4	543	4	TP53	17	7577534	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	4141371	7577534	73617676	201	18116											
TP53	7157	broad.mit.edu	37	chr17	7579698	7579698	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccagcccaacccttgtccttAccagaacgttgttttcagga	9	11	7	14	1	1	1	1	0	0	1	2	2	2	2	5	1	4	2	5	1	3	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:7579698A>C	uc002gim.2	-	3	290	c.96_splice	c.e3+1	p.L32_splice	TP53_uc002gig.1_Splice_Site_p.L32_splice|TP53_uc002gih.2_Splice_Site_p.L32_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Splice_Site_p.L32_splice|TP53_uc010cni.1_Splice_Site_p.L32_splice|TP53_uc002gij.2_Splice_Site_p.L32_splice|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Splice_Site_p.L32_splice|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Splice_Site|TP53_uc010cnk.1_Splice_Site_p.L47_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.S33fs*10(1)|p.P13fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTGTCCTTACCAGAACGTT	0.378		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	70					0	0	0	0	C	7579698	C	C	7579698	5	2	93	1	0	0	0	0	0	0	1	0	16448	405	14	5	1208	5	TP53	17	7579698	Splice_Site	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	2164	7579698	73615512	202	18117											
GIT1	28964	broad.mit.edu	37	chr17	27908398	27908398	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaatgcccattcttgtgaTctgaacaaaaataaaaatgc	16	12	6	7	0	2	2	0	2	2	0	2	2	2	2	1	0	3	1	1	0	7	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:27908398T>A	uc002hef.2	-	7	933	c.719A>T	c.(718-720)GAT>GTT	p.D240V	GIT1_uc002heg.2_Missense_Mutation_p.D240V|GIT1_uc010wbg.1_Missense_Mutation_p.D240V|GIT1_uc010csb.1_Missense_Mutation_p.D240V	NM_014030	NP_054749	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interactor 1	240					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding				0				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		ATTCTTGTGATCTGAACAAAA	0.547													17	53					0	0	0	0	A	27908398	A	A	27908398	3	1	93	1	0	0	0	0	1	0	0	0	6433	1449	50	5	1653	5	GIT1	17	27908398	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	20328700	27908398	53286812	203	18118											
CPD	1362	broad.mit.edu	37	chr17	28788939	28788939	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttaaagataagactggaaaGccaatctctaaagcagtcat	17	9	8	7	0	2	2	1	0	1	2	3	3	2	3	1	1	2	2	1	1	7	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:28788939G>A	uc002hfb.1	+	19	3690	c.3675G>A	c.(3673-3675)AAG>AAA	p.K1225K	CPD_uc010wbo.1_Silent_p.K978K|CPD_uc010wbp.1_Splice_Site	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	1225	Extracellular (Potential).|Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						AGACTGGAAAGCCAATCTCTA	0.353													41	109					0	0	0	0	A	28788939	A	A	28788939	2	1	93	1	0	0	0	0	0	0	0	1	3813	962	34	4		4	CPD	17	28788939	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	880541	28788939	52406271	204	18119											
TMEM132E	124842	broad.mit.edu	37	chr17	32964747	32964747	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccatcctcgtcttcctcatCaactgcatcgtttttgtgct	5	16	6	14	2	3	0	2	0	1	0	7	0	5	0	3	0	3	3	3	0	1	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:32964747C>G	uc002hif.2	+	10	2779	c.2451C>G	c.(2449-2451)ATC>ATG	p.I817M		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	817	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		TCTTCCTCATCAACTGCATCG	0.632													18	98					0	0	0	0	G	32964747	G	G	32964747	3	3	93	1	0	0	0	0	1	0	0	0	16114	816	29	2	2489	2	TMEM132E	17	32964747	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	4175808	32964747	48230463	205	18120											
EIF1	10209	broad.mit.edu	37	chr17	39846111	39846111	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatataagaattcaacagaGaaacggcaggaagaccctta	18	6	8	9	1	1	3	1	0	0	3	1	5	1	4	2	2	2	1	2	2	7	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:39846111G>C	uc002hxj.2	+	2	277	c.113G>C	c.(112-114)AGA>ACA	p.R38T	JUP_uc010wfs.1_Intron|EIF1_uc002hxk.2_Intron	NM_005801	NP_005792	P41567	EIF1_HUMAN	eukaryotic translation initiation factor 1	38					regulation of translational initiation|response to stress	cytoplasm	translation initiation factor activity				0		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			ATTCAACAGAGAAACGGCAGG	0.423											OREG0024409	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	60					0	0	0	0	C	39846111	C	C	39846111	3	2	93	1	0	0	0	0	1	0	0	0	5012	942	33	2	119	2	EIF1	17	39846111	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	6881364	39846111	41349099	206	18121											
CNTNAP1	8506	broad.mit.edu	37	chr17	40843268	40843268	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtctggaccggagctgtgtgGaccctgccttgtactgcaac	6	10	13	12	1	1	0	0	0	1	0	1	3	1	3	3	3	5	3	3	3	2	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:40843268G>C	uc002iay.2	+	14	2389	c.2173G>C	c.(2173-2175)GAC>CAC	p.D725H	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	725	Extracellular (Potential).|Fibrinogen C-terminal.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GAGCTGTGTGGACCCTGCCTT	0.612													22	179					0	0	0	0	C	40843268	C	C	40843268	3	2	93	1	0	0	0	0	1	0	0	0	3661	1174	41	2	2227	2	CNTNAP1	17	40843268	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	997157	40843268	40351942	207	18122											
AOC3	8639	broad.mit.edu	37	chr17	41008480	41008480	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggatgctggggcctgcgaGgtcaaccccctagcttgcct	6	8	13	14	1	1	0	1	0	0	0	1	2	1	1	4	4	5	2	4	4	2	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:41008480G>C	uc002ibv.2	+	4	2365	c.2205G>C	c.(2203-2205)GAG>GAC	p.E735D		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	735	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	GGGCCTGCGAGGTCAACCCCC	0.622													8	30					0	0	0	0	C	41008480	C	C	41008480	3	2	93	1	0	0	0	0	1	0	0	0	728	991	35	4	2219	4	AOC3	17	41008480	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	165212	41008480	40186730	208	18123											
BRCA1	672	broad.mit.edu	37	chr17	41256889	41256889	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatattcaacacttacactcCaaacctgtgtcaagctgaaa	15	10	5	11	0	2	1	2	1	0	0	3	2	3	1	2	0	4	1	2	0	6	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:41256889C>T	uc002icq.2	-	5	529	c.297G>A	c.(295-297)TTG>TTA	p.L99L	BRCA1_uc010whp.1_Silent_p.L52L|BRCA1_uc010whl.1_Silent_p.L99L|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Silent_p.L29L|BRCA1_uc002icu.2_Silent_p.L99L|BRCA1_uc010cyx.2_Silent_p.L52L|BRCA1_uc002ict.2_Silent_p.L99L|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_5'UTR|BRCA1_uc002idc.1_Silent_p.L99L|BRCA1_uc010whr.1_Silent_p.L52L|BRCA1_uc002idd.2_Silent_p.L99L|BRCA1_uc002ide.1_5'UTR|BRCA1_uc010cyy.1_Silent_p.L99L|BRCA1_uc010whs.1_Silent_p.L99L|BRCA1_uc010cyz.2_Silent_p.L52L|BRCA1_uc010cza.2_Silent_p.L73L|BRCA1_uc010wht.1_Intron	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	99					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ACTTACACTCCAAACCTGTGT	0.373			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			24	69					0	0	0	0	T	41256889	T	T	41256889	2	4	93	1	0	0	0	0	0	0	0	1	1503	593	21	4		4	BRCA1	17	41256889	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	248409	41256889	39938321	209	18124											
FAM117A	81558	broad.mit.edu	37	chr17	47797212	47797212	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcctgtgcaggcaggggctGagtcgcaagacaggggaccc	8	5	16	12	1	0	2	0	1	0	1	2	3	1	3	2	5	1	4	2	5	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:47797212G>A	uc002ipk.2	-	5	687	c.618C>T	c.(616-618)CTC>CTT	p.L206L	FAM117A_uc010wlz.1_5'UTR	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	206										ovary(1)	1						GGCAGGGGCTGAGTCGCAAGA	0.602													7	77					0	0	0	0	A	47797212	A	A	47797212	2	1	93	1	0	0	0	0	0	0	0	1	5437	1277	45	2		2	FAM117A	17	47797212	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	6540323	47797212	33397998	210	18125											
CA10	56934	broad.mit.edu	37	chr17	49713219	49713219	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accagagagaaactcacctgCatcctggttatatagacagg	14	8	9	10	0	1	3	1	0	0	3	2	4	2	3	3	2	2	2	3	2	4	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:49713219C>T	uc002itw.3	-	7	1772	c.786G>A	c.(784-786)ATG>ATA	p.M262I	CA10_uc002itu.3_Missense_Mutation_p.M191I|CA10_uc002itv.3_Missense_Mutation_p.M268I|CA10_uc002itx.3_Missense_Mutation_p.M262I|CA10_uc002ity.3_Missense_Mutation_p.M262I|CA10_uc002itz.2_Missense_Mutation_p.M262I	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	262					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			AACTCACCTGCATCCTGGTTA	0.363													15	43					0	0	0	0	T	49713219	T	T	49713219	3	4	93	1	0	0	0	0	1	0	0	0	2523	710	25	4	212	4	CA10	17	49713219	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	1916007	49713219	31481991	211	18126											
SAP30BP	29115	broad.mit.edu	37	chr17	73698631	73698631	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactacattatccaaaggaaGaaagaatttcggaaccctag	18	8	7	8	1	0	2	0	0	0	2	2	4	1	4	2	2	3	0	2	2	9	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:73698631G>A	uc002jpe.2	+	6	522	c.468G>A	c.(466-468)AAG>AAA	p.K156K	SAP30BP_uc002jpc.1_RNA|SAP30BP_uc010wsf.1_RNA|SAP30BP_uc010wsg.1_RNA|SAP30BP_uc002jpf.2_Silent_p.K140K	NM_013260	NP_037392	Q9UHR5	S30BP_HUMAN	transcriptional regulator protein	156					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCAAAGGAAGAAAGAATTTC	0.453													15	55					0	0	0	0	A	73698631	A	A	73698631	2	1	93	1	0	0	0	0	0	0	0	1	13899	933	33	2		2	SAP30BP	17	73698631	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	23985412	73698631	7496579	212	18127											
CDK3	1018	broad.mit.edu	37	chr17	73998411	73998411	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacctgaagccccagaaccTgctcatcaatgagttgggtg	11	8	11	11	0	2	4	2	2	0	2	2	4	2	4	4	1	3	2	4	1	3	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:73998411T>C	uc010dgt.2	+	5	474	c.398T>C	c.(397-399)CTG>CCG	p.L133P	CDK3_uc002jqg.3_Missense_Mutation_p.L161P	NM_001258	NP_001249	Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	133	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						CCCCAGAACCTGCTCATCAAT	0.602													9	53					0	0	0	0	C	73998411	C	C	73998411	3	2	93	1	0	0	0	0	1	0	0	0	3155	1580	55	5	412	5	CDK3	17	73998411	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	299780	73998411	7196799	213	18128											
CCDC57	284001	broad.mit.edu	37	chr17	80151991	80151991	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccggcttccttcagagcctCcagctctttgtgcagtagtt	5	13	9	14	1	2	1	1	0	1	1	4	1	4	1	4	1	3	5	4	1	1	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr17:80151991C>T	uc002kdz.1	-	6	998	c.643G>A	c.(643-645)GAG>AAG	p.E215K	CCDC57_uc002kdx.1_Missense_Mutation_p.E215K	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	215	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			TTCAGAGCCTCCAGCTCTTTG	0.517													21	114					0	0	0	0	T	80151991	T	T	80151991	3	4	93	1	0	0	0	0	1	0	0	0	2840	864	30	2	2156	2	CCDC57	17	80151991	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	6153580	80151991	1043219	214	18129											
RIOK3	8780	broad.mit.edu	37	chr18	21047484	21047484	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgttgtctttcatgcatatgGagggaggtaaatgagcaaaa	13	12	12	4	0	2	1	1	1	1	0	2	3	2	3	0	3	2	4	0	3	5	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr18:21047484G>T	uc002kui.3	+	7	1426	c.809G>T	c.(808-810)GGA>GTA	p.G270V	RIOK3_uc010dls.2_Missense_Mutation_p.G270V|RIOK3_uc010xas.1_Missense_Mutation_p.G254V|RIOK3_uc010xat.1_Nonsense_Mutation_p.E62*	NM_003831	NP_003822	O14730	RIOK3_HUMAN	sudD suppressor of bimD6 homolog	270	Protein kinase.				chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CATGCATATGGAGGGAGGTAA	0.363													17	64					7.05477e-17	7.72784e-17	1	0	T	21047484	T	T	21047484	3	4	93	1	0	0	0	0	1	0	0	0	13444	1174	41	2	835	2	RIOK3	18	21047484	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08		21047484	57029764	215	18130											
FAM108A1	81926	broad.mit.edu	37	chr19	1877366	1877366	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgcgagaagtcgatcacctCgtcctccgtgccgtggatga	7	9	13	12	5	1	2	1	1	0	1	5	5	3	3	4	1	2	0	4	1	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:1877366C>T	uc002lug.2	-	5	1172	c.766G>A	c.(766-768)GAG>AAG	p.E256K	FAM108A1_uc002lud.2_Silent_p.T224T|FAM108A1_uc002lue.2_3'UTR|FAM108A1_uc002luf.2_Missense_Mutation_p.E307K	NM_001130111	NP_001123583	Q96GS6	F18A1_HUMAN	hypothetical protein LOC81926 isoform 2	256						extracellular region	hydrolase activity				0		Ovarian(11;0.000137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGATCACCTCGTCCTCCGTG	0.622													3	17					0	0	0	0	T	1877366	T	T	1877366	3	4	93	1	0	0	0	0	1	0	0	0	5419	893	31	1	170	1	FAM108A1	19	1877366	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		1877366	57251617	216	18131											
TJP3	27134	broad.mit.edu	37	chr19	3747947	3747947	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagggctacacagacggcgaGggggggccctacacggatgt	9	4	18	10	3	0	1	0	0	0	1	0	4	0	2	1	6	2	1	1	6	2	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:3747947G>T	uc010xhv.1	+	18	2577	c.2577G>T	c.(2575-2577)GAG>GAT	p.E859D	TJP3_uc010xhs.1_Missense_Mutation_p.E826D|TJP3_uc010xht.1_Missense_Mutation_p.E790D|TJP3_uc010xhu.1_Missense_Mutation_p.E835D|TJP3_uc010xhw.1_Missense_Mutation_p.E845D	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	840						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGACGGCGAGGGGGGGCCCT	0.697													10	16					1.58986e-06	1.67639e-06	1	0	T	3747947	T	T	3747947	3	4	93	1	0	0	0	0	1	0	0	0	15997	991	35	4	2647	4	TJP3	19	3747947	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1870581	3747947	55381036	217	18132											
COL5A3	50509	broad.mit.edu	37	chr19	10090691	10090691	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggggggccctttggcccaggGaatcctggagggccttgcag	5	7	18	11	0	0	0	0	0	0	0	1	2	1	2	4	7	1	1	4	7	1	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:10090691G>A	uc002mmq.1	-	36	2723	c.2637C>T	c.(2635-2637)TTC>TTT	p.F879F		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	879	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TTGGCCCAGGGAATCCTGGAG	0.612													5	19					0	0	0	0	A	10090691	A	A	10090691	2	1	93	1	0	0	0	0	0	0	0	1	3713	1165	41	2		2	COL5A3	19	10090691	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	6342744	10090691	49038292	218	18133											
COL5A3	50509	broad.mit.edu	37	chr19	10090711	10090711	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatcctggagggccttgcaGaccagggaggccctgaaatg	10	6	15	10	0	0	2	0	1	0	1	1	5	1	4	4	4	1	1	4	4	2	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:10090711G>A	uc002mmq.1	-	36	2703	c.2617C>T	c.(2617-2619)CTG>TTG	p.L873L		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	873	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GGGCCTTGCAGACCAGGGAGG	0.602													6	16					0	0	0	0	A	10090711	A	A	10090711	2	1	93	1	0	0	0	0	0	0	0	1	3713	933	33	2		2	COL5A3	19	10090711	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	20	10090711	49038272	219	18134											
SMARCA4	6597	broad.mit.edu	37	chr19	11145805	11145805	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgacggagaagcagtggctCaaggtacatgctggagaggc	11	6	16	8	1	1	3	1	1	0	2	1	5	1	3	0	5	3	4	0	5	3	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:11145805C>G	uc002mqf.3	+	29	4451	c.4167C>G	c.(4165-4167)CTC>CTG	p.L1389L	SMARCA4_uc010dxp.2_Silent_p.L1389L|SMARCA4_uc010dxo.2_Silent_p.L1389L|SMARCA4_uc010dxq.2_Silent_p.L1356L|SMARCA4_uc010dxr.2_Silent_p.L1356L|SMARCA4_uc002mqj.3_Silent_p.L1356L|SMARCA4_uc010dxs.2_Silent_p.L1356L|SMARCA4_uc010dxt.1_Silent_p.L576L|SMARCA4_uc002mqh.3_Silent_p.L479L|SMARCA4_uc002mqi.1_Silent_p.L559L	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1389					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AGCAGTGGCTCAAGGTACATG	0.657			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				26	25					0	0	0	0	G	11145805	G	G	11145805	2	3	93	1	0	0	0	0	0	0	0	1	14834	813	29	2		2	SMARCA4	19	11145805	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	1055094	11145805	47983178	220	18135											
SMARCA4	6597	broad.mit.edu	37	chr19	11152041	11152041	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtccggcagaagaaatcatCacggaagcgcaagcgagaca	15	3	13	10	4	2	3	2	0	0	3	3	5	3	4	1	3	2	2	1	3	4	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:11152041C>T	uc002mqf.3	+	30	4513	c.4229C>T	c.(4228-4230)TCA>TTA	p.S1410L	SMARCA4_uc010dxp.2_Missense_Mutation_p.S1410L|SMARCA4_uc010dxo.2_Missense_Mutation_p.S1442L|SMARCA4_uc010dxq.2_Missense_Mutation_p.S1377L|SMARCA4_uc010dxr.2_Missense_Mutation_p.S1377L|SMARCA4_uc002mqj.3_Missense_Mutation_p.S1380L|SMARCA4_uc010dxs.2_Missense_Mutation_p.S1380L|SMARCA4_uc002mqh.3_Missense_Mutation_p.S500L	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1410					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AAGAAATCATCACGGAAGCGC	0.607			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				105	61					0	0	0	0	T	11152041	T	T	11152041	3	4	93	1	0	0	0	0	1	0	0	0	14834	838	29	2	4452	2	SMARCA4	19	11152041	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	6236	11152041	47976942	221	18136											
ZNF439	90594	broad.mit.edu	37	chr19	11978656	11978656	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttagttattctgctacccatCgaatacatgaaagaactcac	14	12	5	10	1	2	2	1	1	1	1	3	3	2	2	1	0	4	2	1	0	7	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:11978656C>T	uc002mss.2	+	3	900	c.772C>T	c.(772-774)CGA>TGA	p.R258*	ZNF439_uc002msr.2_Nonsense_Mutation_p.R122*	NM_152262	NP_689475	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	258	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TGCTACCCATCGAATACATGA	0.383													64	67					0	0	0	0	T	11978656	T	T	11978656	4	4	93	1	0	0	0	0	0	1	0	0	17978	876	31	1	782	1	ZNF439	19	11978656	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	826615	11978656	47150327	222	18137											
ZNF791	163049	broad.mit.edu	37	chr19	12739575	12739575	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaatcacactggagaaaaacCctatgagtgtaaggaatgtg	17	8	10	6	0	1	2	1	1	0	1	1	4	1	3	1	2	1	1	1	2	6	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:12739575C>T	uc002mua.2	+	4	1394	c.1232C>T	c.(1231-1233)CCC>CTC	p.P411L	ZNF791_uc010xml.1_Missense_Mutation_p.P379L|ZNF791_uc010dyu.1_Missense_Mutation_p.P302L|ZNF791_uc010xmm.1_Missense_Mutation_p.P302L	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	411					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGAGAAAAACCCTATGAGTGT	0.393													38	162					0	0	0	0	T	12739575	T	T	12739575	3	4	93	1	0	0	0	0	1	0	0	0	18230	623	22	4	1246	4	ZNF791	19	12739575	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	760919	12739575	46389408	223	18138											
CYP4F3	4051	broad.mit.edu	37	chr19	15769192	15769192	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acattgtgctcccagacggcCgggtcatccccaaaggtgcc	8	7	11	15	2	1	1	1	0	0	1	3	1	3	1	5	3	2	1	5	3	1	1	rs142036643	byFrequency	TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:15769192C>A	uc002nbj.2	+	10	1284	c.1234C>A	c.(1234-1236)CGG>AGG	p.R412R	CYP4F3_uc010xok.1_Silent_p.R412R|CYP4F3_uc010xol.1_Silent_p.R412R|CYP4F3_uc010xom.1_Silent_p.R263R|CYP4F3_uc002nbk.2_Silent_p.R412R|CYP4F3_uc010xon.1_Silent_p.R122R	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	412					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						CCCAGACGGCCGGGTCATCCC	0.642													14	85					0.00185496	0.00191042	1	0	A	15769192	A	A	15769192	2	1	93	1	0	0	0	0	0	0	0	1	4207	643	23	3		3	CYP4F3	19	15769192	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	3029617	15769192	43359791	224	18139											
TMEM59L	25789	broad.mit.edu	37	chr19	18729056	18729056	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtctgaagagccacaggaCaatgacttcctcagttgcat	12	9	10	10	0	2	3	1	2	1	1	3	5	3	4	2	1	2	2	2	1	2	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:18729056C>T	uc002njy.3	+	6	843	c.756C>T	c.(754-756)GAC>GAT	p.D252D		NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	252						Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						AGCCACAGGACAATGACTTCC	0.627													6	42					0	0	0	0	T	18729056	T	T	18729056	2	4	93	1	0	0	0	0	0	0	0	1	16252	477	17	4		4	TMEM59L	19	18729056	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	2959864	18729056	40399927	225	18140											
ZNF208	7757	broad.mit.edu	37	chr19	22156015	22156015	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattcttcacatttgtagggTttctcaccagtatgaattct	9	17	6	9	0	4	1	2	1	3	0	5	1	4	1	1	1	0	3	1	1	3	7			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:22156015T>C	uc002nqp.2	-	5	1670	c.1521A>G	c.(1519-1521)AAA>AAG	p.K507K	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATTTGTAGGGTTTCTCACCAG	0.368													8	74					0	0	0	0	C	22156015	C	C	22156015	2	2	93	1	0	0	0	0	0	0	0	1	17833	1722	60	5		5	ZNF208	19	22156015	Silent	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	3426959	22156015	36972968	226	18141											
YIF1B	90522	broad.mit.edu	37	chr19	38800243	38800243	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgaaaagctggtgggggtcGgccatgcccggctgggacac	7	6	17	11	3	0	0	0	0	0	0	2	2	0	1	2	6	2	2	2	6	2	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:38800243G>A	uc002ohz.2	-	2	148	c.99C>T	c.(97-99)GCC>GCT	p.A33A	YIF1B_uc002ohw.2_Silent_p.A2A|YIF1B_uc002ohx.2_Silent_p.A18A|YIF1B_uc010xtx.1_Silent_p.A16A|YIF1B_uc010xty.1_Silent_p.A2A|YIF1B_uc002oia.2_Silent_p.A30A|YIF1B_uc002ohy.2_Silent_p.A30A|YIF1B_uc002oib.2_Silent_p.A30A	NM_001039672	NP_001034761	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B isoform 5	33	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GGTGGGGGTCGGCCATGCCCG	0.642													4	11					0	0	0	0	A	38800243	A	A	38800243	2	1	93	1	0	0	0	0	0	0	0	1	17544	1103	39	1		1	YIF1B	19	38800243	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	16644228	38800243	20328740	227	18142											
CYP2A7	1549	broad.mit.edu	37	chr19	41387649	41387649	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacacggggccatagcacTcactgaactgatggaggcga	12	6	13	10	2	1	3	1	3	0	0	1	5	1	4	1	4	3	1	1	4	3	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:41387649T>A	uc002opm.2	-	2	730	c.188A>T	c.(187-189)GAG>GTG	p.E63V	CYP2A7_uc002opo.2_Missense_Mutation_p.E63V|CYP2A7_uc002opn.2_Intron	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	63						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GCCATAGCACTCACTGAACTG	0.622													3	15					0	0	0	0	A	41387649	A	A	41387649	3	1	93	1	0	0	0	0	1	0	0	0	4180	1551	54	5	1328	5	CYP2A7	19	41387649	Missense_Mutation	SNP	T	TCGA-CQ-5326-01A-01D-1870-08	2587406	41387649	17741334	228	18143											
CIC	23152	broad.mit.edu	37	chr19	42799110	42799110	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagcagccccctggagctGaggctcctctccctgtaccg	5	7	12	17	2	1	1	0	1	1	0	3	3	2	3	5	3	4	4	5	3	1	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:42799110G>T	uc002otf.1	+	20	4634	c.4594G>T	c.(4594-4596)GAG>TAG	p.E1532*		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	1532	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CCCTGGAGCTGAGGCTCCTCT	0.343			T	DUX4	soft tissue sarcoma								7	37					0.00448238	0.00460112	1	0	T	42799110	T	T	42799110	4	4	93	1	0	0	0	0	0	1	0	0	3439	1291	45	2	4672	2	CIC	19	42799110	Nonsense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1411461	42799110	16329873	229	18144											
SIGLEC9	27180	broad.mit.edu	37	chr19	51630370	51630370	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtgcagttgatgcagttGacagcaatccccctgccagg	8	10	11	12	0	1	2	0	2	1	0	2	2	2	2	3	1	4	5	3	1	1	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:51630370G>T	uc002pvu.2	+	4	899	c.832G>T	c.(832-834)GAC>TAC	p.D278Y	SIGLEC9_uc010yct.1_Missense_Mutation_p.D278Y	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	278	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		TGATGCAGTTGACAGCAATCC	0.572													16	124					9.16793e-09	9.8002e-09	1	0	T	51630370	T	T	51630370	3	4	93	1	0	0	0	0	1	0	0	0	14380	1290	45	2	846	2	SIGLEC9	19	51630370	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	8831260	51630370	7498613	230	18145											
LENG1	79165	broad.mit.edu	37	chr19	54662148	54662148	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcctctgctgcttcaagctCaggcagtgagttctgatgtc	6	12	11	12	1	4	2	2	2	2	0	5	2	4	2	1	1	3	5	1	1	1	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr19:54662148C>T	uc002qdm.2	-	2	197	c.184G>A	c.(184-186)GAG>AAG	p.E62K		NM_024316	NP_077292	Q96BZ8	LENG1_HUMAN	leukocyte receptor cluster (LRC) member 1	62										ovary(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCTTCAAGCTCAGGCAGTGAG	0.527													19	118					0	0	0	0	T	54662148	T	T	54662148	3	4	93	1	0	0	0	0	1	0	0	0	8763	835	29	2	622	2	LENG1	19	54662148	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	3031778	54662148	4466835	231	18146											
MCM8	84515	broad.mit.edu	37	chr20	5932702	5932702	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaggatttggacgaggaaGatttcaaagctggaaaaggg	15	7	15	4	1	1	2	1	0	0	2	1	7	1	6	0	5	1	1	0	5	4	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr20:5932702G>A	uc002wmi.2	+	2	418	c.41G>A	c.(40-42)AGA>AAA	p.R14K	TRMT6_uc002wmh.1_5'Flank|TRMT6_uc010zra.1_5'Flank|TRMT6_uc010gbn.1_5'Flank|TRMT6_uc010gbo.1_5'Flank|MCM8_uc002wmj.2_Missense_Mutation_p.R14K|MCM8_uc002wmk.2_Missense_Mutation_p.R14K|MCM8_uc002wml.2_Missense_Mutation_p.R14K|MCM8_uc010gbp.2_Missense_Mutation_p.R14K	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	14					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						GGACGAGGAAGATTTCAAAGC	0.413													17	47					0	0	0	0	A	5932702	A	A	5932702	3	1	93	1	0	0	0	0	1	0	0	0	9446	942	33	2	43	2	MCM8	20	5932702	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08		5932702	57092818	232	18147											
RIN2	54453	broad.mit.edu	37	chr20	19937330	19937330	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgtgcccgggactcaggctAtgacagcctctccaacaggc	8	7	11	15	1	2	1	1	1	1	0	3	2	2	2	3	3	3	1	3	3	2	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr20:19937330A>G	uc002wro.1	+	3	266	c.230A>G	c.(229-231)TAT>TGT	p.Y77C	RIN2_uc010gcu.1_Missense_Mutation_p.Y77C|RIN2_uc010gcv.1_5'UTR	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	77					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						GACTCAGGCTATGACAGCCTC	0.587													6	21					0	0	0	0	G	19937330	G	G	19937330	3	3	93	1	0	0	0	0	1	0	0	0	13437	449	16	5	240	5	RIN2	20	19937330	Missense_Mutation	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	14004628	19937330	43088190	233	18148											
DNMT3B	1789	broad.mit.edu	37	chr20	31380492	31380492	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggagactcattggaggacCagctgaagcccatgttggag	10	8	14	9	0	1	2	1	1	0	1	1	6	1	5	2	4	2	2	2	4	1	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr20:31380492C>G	uc002wyc.2	+	9	1303	c.982C>G	c.(982-984)CAG>GAG	p.Q328E	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_Intron|DNMT3B_uc002wyd.2_Missense_Mutation_p.Q328E|DNMT3B_uc002wye.2_Missense_Mutation_p.Q328E|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.Q286E|DNMT3B_uc010zua.1_Missense_Mutation_p.Q252E|DNMT3B_uc002wyf.2_Missense_Mutation_p.Q340E|DNMT3B_uc002wyg.2_Missense_Mutation_p.Q27E	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	328					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						ATTGGAGGACCAGCTGAAGCC	0.612													22	64					0	0	0	0	G	31380492	G	G	31380492	3	3	93	1	0	0	0	0	1	0	0	0	4699	595	21	4	1052	4	DNMT3B	20	31380492	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	11443162	31380492	31645028	234	18149											
RBL1	5933	broad.mit.edu	37	chr20	35695270	35695270	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccgtaaagtcagcagtatGaaaatcagatggtaaaccta	17	8	9	7	1	2	2	2	1	0	1	2	2	2	2	2	1	3	4	2	1	8	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr20:35695270G>A	uc002xgi.2	-	6	782	c.703C>T	c.(703-705)CAT>TAT	p.H235Y	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.H235Y|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	235					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				TCAGCAGTATGAAAATCAGAT	0.383													20	72					0	0	0	0	A	35695270	A	A	35695270	3	1	93	1	0	0	0	0	1	0	0	0	13174	1290	45	2	2580	2	RBL1	20	35695270	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	4314778	35695270	27330250	235	18150											
NCOA3	8202	broad.mit.edu	37	chr20	46265274	46265274	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacaccagcagtataacttCttgtggggacggaaatgttg	12	10	12	7	1	1	1	0	0	1	1	1	3	1	3	1	3	2	3	1	3	3	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr20:46265274C>T	uc002xtk.2	+	12	2349	c.2144C>T	c.(2143-2145)TCT>TTT	p.S715F	NCOA3_uc010ght.1_Missense_Mutation_p.S725F|NCOA3_uc002xtl.2_Missense_Mutation_p.S715F|NCOA3_uc002xtm.2_Missense_Mutation_p.S715F|NCOA3_uc002xtn.2_Missense_Mutation_p.S715F|NCOA3_uc010zyc.1_Missense_Mutation_p.S510F	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	715					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						AGTATAACTTCTTGTGGGGAC	0.473													22	64					0	0	0	0	T	46265274	T	T	46265274	3	4	93	1	0	0	0	0	1	0	0	0	10284	913	32	2	2212	2	NCOA3	20	46265274	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	10570004	46265274	16760246	236	18151											
PPP1R3D	5509	broad.mit.edu	37	chr20	58514189	58514189	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggtggtcgttgttgtcccaGtactcggcacccgccacttg	4	11	12	14	4	0	0	0	0	0	0	3	0	1	0	3	3	1	4	3	3	1	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr20:58514189G>C	uc002ybb.2	-	1	1164	c.798C>G	c.(796-798)TAC>TAG	p.Y266*	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	266	CBM21.				glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			TGTTGTCCCAGTACTCGGCAC	0.617													20	35					0	0	0	0	C	58514189	C	C	58514189	4	2	93	1	0	0	0	0	0	1	0	0	12434	1024	36	4	105	4	PPP1R3D	20	58514189	Nonsense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	12248915	58514189	4511331	237	18152											
NTSR1	4923	broad.mit.edu	37	chr20	61386205	61386205	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggccatcgagcctggcaggGtccaggccctgcggcacggc	5	5	16	15	3	0	0	0	0	0	0	2	1	1	0	4	6	2	2	4	6	0	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr20:61386205G>A	uc002ydf.2	+	2	1254	c.883G>A	c.(883-885)GTC>ATC	p.V295I		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	295	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			GCCTGGCAGGGTCCAGGCCCT	0.692													9	28					0	0	0	0	A	61386205	A	A	61386205	3	1	93	1	0	0	0	0	1	0	0	0	10764	1261	44	4	889	4	NTSR1	20	61386205	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	2872016	61386205	1639315	238	18153											
ARFGAP1	55738	broad.mit.edu	37	chr20	61917778	61917778	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttttttcggggaaagcaGagggccccttggacaggtat	8	11	13	9	1	0	1	0	0	0	1	1	3	0	3	3	5	1	2	3	5	2	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr20:61917778G>C	uc002yem.2	+	12	1007	c.895G>C	c.(895-897)GAG>CAG	p.E299Q	ARFGAP1_uc011aas.1_Missense_Mutation_p.E254Q|ARFGAP1_uc011aat.1_Missense_Mutation_p.E186Q|ARFGAP1_uc002yel.2_Missense_Mutation_p.E307Q|ARFGAP1_uc002yen.2_Missense_Mutation_p.Q378H|ARFGAP1_uc002yeo.1_RNA|hsa-mir-4326|MI0015866_5'Flank	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	299					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					GGGGAAAGCAGAGGGCCCCTT	0.627													5	32					0	0	0	0	C	61917778	C	C	61917778	3	2	93	1	0	0	0	0	1	0	0	0	849	943	33	2	971	2	ARFGAP1	20	61917778	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	531573	61917778	1107742	239	18154											
NPBWR2	2832	broad.mit.edu	37	chr20	62738005	62738005	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgacggccgtgttgccagtCagccccacagcacagatccc	9	6	10	16	2	1	2	1	1	0	1	2	2	2	2	5	1	3	2	5	1	0	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr20:62738005C>G	uc011abt.1	-	1	180	c.180G>C	c.(178-180)CTG>CTC	p.L60L		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	60	Helical; Name=1; (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					TGTTGCCAGTCAGCCCCACAG	0.607													17	35					0	0	0	0	G	62738005	G	G	62738005	2	3	93	1	0	0	0	0	0	0	0	1	10623	813	29	2		2	NPBWR2	20	62738005	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	820227	62738005	287515	240	18155											
GART	2618	broad.mit.edu	37	chr21	34903798	34903798	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatgaatatacataccgaCacctcttctccgtcaagaag	15	9	6	11	2	3	3	1	1	2	2	4	4	3	3	3	0	2	0	3	0	7	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr21:34903798C>T	uc002yrx.2	-	6	729	c.594G>A	c.(592-594)GTG>GTA	p.V198V	GART_uc002yrz.2_Silent_p.V198V|GART_uc010gmd.2_5'UTR|GART_uc002yry.2_Silent_p.V198V|GART_uc002ysa.2_Silent_p.V198V	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	198	ATP (By similarity).|ATP-grasp.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	TACATACCGACACCTCTTCTC	0.363													39	195					0	0	0	0	T	34903798	T	T	34903798	2	4	93	1	0	0	0	0	0	0	0	1	6278	465	17	4		4	GART	21	34903798	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08		34903798	13226097	241	18156											
ITSN1	6453	broad.mit.edu	37	chr21	35093561	35093561	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatagtttaaagccaatatCtggattcattactggtaatc	13	14	6	8	0	2	0	1	0	1	0	3	1	2	1	2	2	2	2	2	2	7	7			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr21:35093561C>G	uc002yta.1	+	3	375	c.107C>G	c.(106-108)TCT>TGT	p.S36C	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.S36C|ITSN1_uc010gmg.2_Missense_Mutation_p.S36C|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.S36C|ITSN1_uc010gmi.2_Missense_Mutation_p.S36C|ITSN1_uc010gmj.2_Translation_Start_Site|ITSN1_uc002ysy.2_Missense_Mutation_p.S36C|ITSN1_uc002ysx.2_Missense_Mutation_p.S36C|ITSN1_uc002ytb.1_Missense_Mutation_p.S36C|ITSN1_uc002ytc.1_Missense_Mutation_p.S36C|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.S36C|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.S36C|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_5'Flank	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	36	EH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						AAGCCAATATCTGGATTCATT	0.398													19	68					0	0	0	0	G	35093561	G	G	35093561	3	3	93	1	0	0	0	0	1	0	0	0	7965	913	32	2	113	2	ITSN1	21	35093561	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	189763	35093561	13036334	242	18157											
LSS	4047	broad.mit.edu	37	chr21	47626622	47626623	+	Frame_Shift_Ins	INS	-	C	C																															ttcagcagctccagcaagtgINSccccccacgcttggtctcat																										TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr21:47626622_47626623insC	uc002zij.2	-	16	1606_1607	c.1527_1528insG	c.(1525-1530)GGGCACfs	p.G509fs	LSS_uc011afv.1_Frame_Shift_Ins_p.G498fs|LSS_uc002zil.2_Frame_Shift_Ins_p.G509fs|LSS_uc002zik.2_Frame_Shift_Ins_p.G429fs	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	509_510	PFTB 2.				cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					TCCAGCAAGTGCCCCCCACGCT	0.599													---	---	---								C	47626623	C	C	47626622	7	5	93	1	0	1	1	0	0	0	0	0	9115	1319	46	0	698	0	LSS	21	47626622	Frame_Shift_Ins	INS	-	TCGA-CQ-5326-01A-01D-1870-08	12533061	47626622	503273	243	18158											
SERPIND1	3053	broad.mit.edu	37	chr22	21133697	21133697	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atcagctagagaaaggagggGaaactgctcagtctgcagat	14	7	13	7	0	3	2	2	0	1	2	3	5	3	4	0	3	4	3	0	3	3	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr22:21133697G>C	uc002ztb.1	+	2	164	c.97G>C	c.(97-99)GAA>CAA	p.E33Q	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.E61Q	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	33					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	GAAAGGAGGGGAAACTGCTCA	0.493													9	65					0	0	0	0	C	21133697	C	C	21133697	3	2	93	1	0	0	0	0	1	0	0	0	14175	1175	41	2	99	2	SERPIND1	22	21133697	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08		21133697	30170869	244	18159											
RNF185	91445	broad.mit.edu	37	chr22	31592944	31592944	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaagacccctcctcgtcctCaaggacagaggccagagccg	11	4	11	15	2	1	4	1	0	0	4	4	5	3	5	6	2	1	0	6	2	2	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr22:31592944C>G	uc003akb.2	+	5	531	c.331C>G	c.(331-333)CAA>GAA	p.Q111E	RNF185_uc010gwh.2_RNA|RNF185_uc011alm.1_Missense_Mutation_p.Q49E|RNF185_uc003akc.2_Missense_Mutation_p.Q49E|RNF185_uc003ake.2_Intron	NM_152267	NP_689480	Q96GF1	RN185_HUMAN	ring finger protein 185 isoform 1	111						integral to membrane	zinc ion binding				0						TCCTCGTCCTCAAGGACAGAG	0.458													14	104					0	0	0	0	G	31592944	G	G	31592944	3	3	93	1	0	0	0	0	1	0	0	0	13533	827	29	2	345	2	RNF185	22	31592944	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	10459247	31592944	19711622	245	18160											
DEPDC5	9681	broad.mit.edu	37	chr22	32289694	32289694	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaatgcagcctttgagatcaAgctgcactggatggcggtga	10	9	14	8	1	1	2	1	2	0	1	1	5	1	3	1	3	4	3	1	3	2	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr22:32289694A>T	uc003als.2	+	38	4209	c.4067A>T	c.(4066-4068)AAG>ATG	p.K1356M	DEPDC5_uc011als.1_Missense_Mutation_p.K1287M|DEPDC5_uc011alu.1_Missense_Mutation_p.K1387M|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.K1378M|DEPDC5_uc003alu.2_Missense_Mutation_p.K805M|DEPDC5_uc003alv.2_RNA|DEPDC5_uc003alw.2_Missense_Mutation_p.K654M|DEPDC5_uc011alx.1_Missense_Mutation_p.K204M|DEPDC5_uc010gwk.2_Missense_Mutation_p.K382M|DEPDC5_uc011aly.1_Missense_Mutation_p.K204M	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1356					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						TTTGAGATCAAGCTGCACTGG	0.537													29	61					0	0	0	0	T	32289694	T	T	32289694	3	4	93	1	0	0	0	0	1	0	0	0	4464	72	3	5	4301	5	DEPDC5	22	32289694	Missense_Mutation	SNP	A	TCGA-CQ-5326-01A-01D-1870-08	696750	32289694	19014872	246	18161											
MGAT3	4248	broad.mit.edu	37	chr22	39883475	39883475	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccgagaactggcctccctCagccctaacctggtgtccag	7	7	9	18	1	1	1	1	0	0	1	3	2	3	1	7	2	3	0	7	2	2	1	rs145462426	byFrequency	TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr22:39883475C>T	uc003axv.3	+	2	362	c.123C>T	c.(121-123)CTC>CTT	p.L41L	MGAT3_uc010gxy.2_Silent_p.L41L	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	41	Lumenal (Potential).|Pro-rich.				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					TGGCCTCCCTCAGCCCTAACC	0.602													66	300					0	0	0	0	T	39883475	T	T	39883475	2	4	93	1	0	0	0	0	0	0	0	1	9597	813	29	2		2	MGAT3	22	39883475	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	7593781	39883475	11421091	247	18162											
MGAT3	4248	broad.mit.edu	37	chr22	39884111	39884111	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagccgcggccgctcaagttCcgggagatgctgaccaatgg	8	6	15	12	4	1	2	1	1	0	1	2	4	2	2	4	3	2	3	4	3	2	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr22:39884111C>G	uc003axv.3	+	2	998	c.759C>G	c.(757-759)TTC>TTG	p.F253L	MGAT3_uc010gxy.2_Missense_Mutation_p.F253L	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	253	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					CGCTCAAGTTCCGGGAGATGC	0.642													16	81					0	0	0	0	G	39884111	G	G	39884111	3	3	93	1	0	0	0	0	1	0	0	0	9597	854	30	2	761	2	MGAT3	22	39884111	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	636	39884111	11420455	248	18163											
EP300	2033	broad.mit.edu	37	chr22	41553402	41553402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaagccttggatactgttGtggcagaaaggtaagaaatg	14	9	13	5	0	0	2	0	0	0	2	0	3	0	3	1	3	2	4	1	3	5	4			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr22:41553402G>A	uc003azl.3	+	18	3886	c.3491G>A	c.(3490-3492)TGT>TAT	p.C1164Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1164					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGATACTGTTGTGGCAGAAAG	0.393			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				35	108					0	0	0	0	A	41553402	A	A	41553402	3	1	93	1	0	0	0	0	1	0	0	0	5172	1377	48	4	3561	4	EP300	22	41553402	Missense_Mutation	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	1669291	41553402	9751164	249	18164											
PKDREJ	10343	broad.mit.edu	37	chr22	46657755	46657755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattgaccatttatagaaatCacggcttgcacaatttgtgc	13	13	7	8	1	1	2	1	1	0	1	1	2	1	2	1	1	2	2	1	1	5	6			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr22:46657755C>T	uc003bhh.2	-	1	1465	c.1465G>A	c.(1465-1467)GAT>AAT	p.D489N		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	489	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TTATAGAAATCACGGCTTGCA	0.378													59	293					0	0	0	0	T	46657755	T	T	46657755	3	4	93	1	0	0	0	0	1	0	0	0	12025	826	29	2	5300	2	PKDREJ	22	46657755	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	5104353	46657755	4646811	250	18165											
TBC1D22A	25771	broad.mit.edu	37	chr22	47193380	47193380	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctctgcagaggtcccagtCtctcccacactcggccaccg	6	7	8	20	2	2	1	0	0	2	1	6	1	4	1	5	2	1	1	5	2	0	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr22:47193380C>G	uc003bib.2	+	4	635	c.500C>G	c.(499-501)TCT>TGT	p.S167C	TBC1D22A_uc010haf.2_Missense_Mutation_p.S137C|TBC1D22A_uc003bic.2_Intron|TBC1D22A_uc003bie.2_Intron|TBC1D22A_uc003bid.2_RNA|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_Missense_Mutation_p.S120C	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	167						intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		AGGTCCCAGTCTCTCCCACAC	0.652											OREG0026659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	92					0	0	0	0	G	47193380	G	G	47193380	3	3	93	1	0	0	0	0	1	0	0	0	15677	913	32	2	514	2	TBC1D22A	22	47193380	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	535625	47193380	4111186	251	18166											
SHANK3	85358	broad.mit.edu	37	chr22	51137179	51137179	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaaggccgcacgggctggttCccggccgactgcgtggagga	7	5	17	12	5	0	0	0	0	0	0	1	3	1	2	3	6	1	3	3	6	1	1			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chr22:51137179C>T	uc003bne.1	+	13	1608	c.1608C>T	c.(1606-1608)TTC>TTT	p.F536F	SHANK3_uc003bnf.1_5'UTR	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	536										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CGGGCTGGTTCCCGGCCGACT	0.667													10	48					0	0	0	0	T	51137179	T	T	51137179	2	4	93	1	0	0	0	0	0	0	0	1	14331	854	30	2		2	SHANK3	22	51137179	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	3943799	51137179	167387	252	18167											
ARSD	414	broad.mit.edu	37	chrX	2838724	2838724	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggagtccacctgagcctgcGttccactgaagggcccggta	7	7	14	13	2	0	2	0	2	0	0	2	3	2	3	5	3	2	2	5	3	2	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chrX:2838724G>A	uc004cqy.2	-	4	433	c.357C>T	c.(355-357)AAC>AAT	p.N119N	ARSD_uc004cqz.1_Intron|ARSD_uc004cra.1_Silent_p.N119N|ARSD_uc004crb.3_Silent_p.N119N	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	119						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTGAGCCTGCGTTCCACTGAA	0.527													18	17					0	0	0	0	A	2838724	A	A	2838724	2	1	93	1	0	0	0	0	0	0	0	1	991	1136	40	1		1	ARSD	23	2838724	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08		2838724	152431836	253	18168											
GPKOW	27238	broad.mit.edu	37	chrX	48979986	48979986	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cccgagtcggccagccgcctCcgtgcggacgtgcgagtgaa	6	5	15	15	7	0	1	0	1	0	0	2	4	1	2	5	2	3	0	5	2	1	0			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chrX:48979986C>G	uc004dmr.2	-	1	94	c.87G>C	c.(85-87)CGG>CGC	p.R29R		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	29						nucleus	nucleic acid binding			ovary(2)	2						CCAGCCGCCTCCGTGCGGACG	0.622													6	6					0	0	0	0	G	48979986	G	G	48979986	2	3	93	1	0	0	0	0	0	0	0	1	6651	842	30	2		2	GPKOW	23	48979986	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	46141262	48979986	106290574	254	18169											
PGK1	5230	broad.mit.edu	37	chrX	77365367	77365367	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcatctttcttttttagagtCgacttcaatgttcctatgaa	9	18	6	8	1	3	2	1	1	2	1	5	3	4	2	1	0	0	2	1	0	4	7			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chrX:77365367C>G	uc004ecz.3	+	2	241	c.69C>G	c.(67-69)GTC>GTG	p.V23V	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_5'UTR	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	23					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						TTTTTAGAGTCGACTTCAATG	0.383													29	47					0	0	0	0	G	77365367	G	G	77365367	2	3	93	1	0	0	0	0	0	0	0	1	11845	871	31	3		3	PGK1	23	77365367	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	28385381	77365367	77905193	255	18170											
DIAPH2	1730	broad.mit.edu	37	chrX	95993660	95993660	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaacatcctattgattctCaagtcgcgatgagtgagttt	10	15	8	8	2	2	3	2	3	1	0	5	4	3	3	1	0	1	1	1	0	3	5			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chrX:95993660C>G	uc004efu.3	+	3	637	c.241C>G	c.(241-243)CAA>GAA	p.Q81E	DIAPH2_uc004eft.3_Missense_Mutation_p.Q81E|DIAPH2_uc004efs.2_Missense_Mutation_p.Q81E	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	81					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						TATTGATTCTCAAGTCGCGAT	0.323													20	28					0	0	0	0	G	95993660	G	G	95993660	3	3	93	1	0	0	0	0	1	0	0	0	4541	827	29	2	251	2	DIAPH2	23	95993660	Missense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	18628293	95993660	59276900	256	18171											
NUP62CL	54830	broad.mit.edu	37	chrX	106391016	106391016	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggagtccatatgggcattCagaattctgcagatctggtg	10	11	13	7	0	3	2	1	0	2	2	4	3	4	3	1	3	1	2	1	3	2	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chrX:106391016C>T	uc004ena.2	-	8	813	c.554G>A	c.(553-555)TGA>TAA	p.*185*	NUP62CL_uc004enb.2_RNA	NM_017681	NP_060151	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like	185					protein transport	nuclear pore	structural constituent of nuclear pore				0						TATGGGCATTCAGAATTCTGC	0.358													39	48					0	0	0	0	T	106391016	T	T	106391016	2	4	93	1	0	0	0	0	0	0	0	1	10823	837	29	2		2	NUP62CL	23	106391016	Silent	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	10397356	106391016	48879544	257	18172											
DCAF12L1	139170	broad.mit.edu	37	chrX	125685629	125685629	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggaatgggagcccacggcGtacacagacatatcatcaca	13	6	11	11	2	2	1	2	0	0	1	2	3	2	3	1	3	2	1	1	3	3	2			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chrX:125685629G>A	uc004eul.2	-	1	1214	c.963C>T	c.(961-963)TAC>TAT	p.Y321Y		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	321										skin(3)|ovary(1)	4						AGCCCACGGCGTACACAGACA	0.597													14	29					0	0	0	0	A	125685629	A	A	125685629	2	1	93	1	0	0	0	0	0	0	0	1	4281	1140	40	1		1	DCAF12L1	23	125685629	Silent	SNP	G	TCGA-CQ-5326-01A-01D-1870-08	19294613	125685629	29584931	258	18173											
OCRL	4952	broad.mit.edu	37	chrX	128710497	128710497	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgtatgaaaagaccaatcCgagaagttcctgttaccaaa	15	8	8	10	2	0	3	0	1	0	2	2	4	2	3	5	0	1	3	5	0	7	3			TCGA-CQ-5326-01A-01D-1870-08	TCGA-CQ-5326-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	199249f9-808d-4565-bb6b-82724f61edaa	1e880285-c636-4204-87bc-1e9d0bb69355	g.chrX:128710497C>T	uc004euq.2	+	18	2248	c.2083C>T	c.(2083-2085)CGA>TGA	p.R695*	OCRL_uc004eur.2_Nonsense_Mutation_p.R695*	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	695					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						AAGACCAATCCGAGAAGTTCC	0.403													12	22					0	0	0	0	T	128710497	T	T	128710497	4	4	93	1	0	0	0	0	0	1	0	0	10877	644	23	1	2153	1	OCRL	23	128710497	Nonsense_Mutation	SNP	C	TCGA-CQ-5326-01A-01D-1870-08	3024868	128710497	26560063	259	18174											
MTOR	2475	broad.mit.edu	37	chr1	11187151	11187151	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccttgacattccctgatttCatgtacttcctgcaccactc	7	15	4	15	0	1	2	1	2	0	0	5	2	4	2	4	0	2	2	4	0	1	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:11187151C>T	uc001asd.2	-	45	6388	c.6267G>A	c.(6265-6267)ATG>ATA	p.M2089I	MTOR_uc001asc.2_Missense_Mutation_p.M294I	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	2089					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TCCCTGATTTCATGTACTTCC	0.488													8	38					0	0	0	0	T	11187151	T	T	11187151	3	4	94	1	0	0	0	0	1	0	0	0	10007	826	29	2	1438	2	MTOR	1	11187151	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08		11187151	238063470	1	18175											
EPHA2	1969	broad.mit.edu	37	chr1	16475129	16475130	+	Frame_Shift_Del	DEL	CA	-	-																															acacggacggagagcagcgcCacacaggcaccgatatcctg																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:16475129_16475130delCA	uc001aya.1	-	3	703_704	c.566_567delTG	c.(565-567)GTGfs	p.V189fs	EPHA2_uc010oca.1_Frame_Shift_Del_p.V189fs	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	189	Extracellular (Potential).|Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	AGAGCAGCGCCACACAGGCACC	0.644													---	---	---								-	16475130	-	-	16475129	7	5	94	1	0	1	0	1	0	0	0	0	5191	581	21	0	2423	0	EPHA2	1	16475129	Frame_Shift_Del	DEL	CA	TCGA-CQ-5327-01A-01D-1683-08	5287978	16475129	232775492	2	18176											
PTPRU	10076	broad.mit.edu	37	chr1	29602008	29602008	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgctgagatccaggcccGtcagctgaccctgcagtggg	6	10	13	12	1	1	2	1	2	0	1	2	3	2	2	3	2	3	3	3	2	0	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:29602008G>A	uc001bru.2	+	8	1303	c.1193G>A	c.(1192-1194)CGT>CAT	p.R398H	PTPRU_uc001brv.2_Missense_Mutation_p.R398H|PTPRU_uc001brw.2_Missense_Mutation_p.R398H|PTPRU_uc009vtq.2_Missense_Mutation_p.R398H|PTPRU_uc009vtr.2_Missense_Mutation_p.R398H	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	398	Fibronectin type-III 2.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		ATCCAGGCCCGTCAGCTGACC	0.483													21	18					0	0	0	0	A	29602008	A	A	29602008	3	1	94	1	0	0	0	0	1	0	0	0	12878	1145	40	1	1223	1	PTPRU	1	29602008	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	13126879	29602008	219648613	3	18177											
CSMD2	114784	broad.mit.edu	37	chr1	34049245	34049245	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatttgactgacttaccatCaaaaatctcaaactcatcat	15	12	3	11	0	4	2	4	2	1	0	5	2	4	2	1	0	2	1	1	0	4	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:34049245C>G	uc001bxn.1	-	48	7272	c.7243G>C	c.(7243-7245)GAT>CAT	p.D2415H	CSMD2_uc001bxm.1_Missense_Mutation_p.D2413H	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2415	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GACTTACCATCAAAAATCTCA	0.328													20	98					0	0	0	0	G	34049245	G	G	34049245	3	3	94	1	0	0	0	0	1	0	0	0	3962	826	29	2	3308	2	CSMD2	1	34049245	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	4447237	34049245	215201376	4	18178											
EBNA1BP2	10969	broad.mit.edu	37	chr1	43630162	43630162	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgttcgttttccaggtctCttctacagaaaaagacatac	11	14	6	10	1	2	2	0	0	2	2	5	2	3	2	1	1	2	2	1	1	4	7			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:43630162C>T	uc001cin.2	-	9	1070	c.873G>A	c.(871-873)AAG>AAA	p.K291K	EBNA1BP2_uc001cio.2_Silent_p.K346K|EBNA1BP2_uc001cim.2_Silent_p.K186K|EBNA1BP2_uc010ojx.1_Silent_p.K346K	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	291					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTCCAGGTCTCTTCTACAGAA	0.448													12	66					0	0	0	0	T	43630162	T	T	43630162	2	4	94	1	0	0	0	0	0	0	0	1	4907	912	32	2		2	EBNA1BP2	1	43630162	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	9580917	43630162	205620459	5	18179											
CYP4B1	1580	broad.mit.edu	37	chr1	47278285	47278285	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtgttcactgagtctacacGtatcatgctggtgagctccc	7	12	10	12	2	3	2	2	2	1	0	4	2	4	2	1	1	3	4	1	1	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:47278285G>A	uc001cqm.3	+	4	569	c.485G>A	c.(484-486)CGT>CAT	p.R162H	CYP4B1_uc009vyl.1_5'UTR|CYP4B1_uc001cqn.3_Missense_Mutation_p.R162H|CYP4B1_uc009vym.2_Missense_Mutation_p.R147H|CYP4B1_uc010omk.1_5'UTR|CYP4B1_uc010oml.1_5'UTR	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	162					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					GAGTCTACACGTATCATGCTG	0.572													20	46					0	0	0	0	A	47278285	A	A	47278285	3	1	94	1	0	0	0	0	1	0	0	0	4202	1145	40	1	499	1	CYP4B1	1	47278285	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	3648123	47278285	201972336	6	18180											
GBP2	2634	broad.mit.edu	37	chr1	89579771	89579771	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagacttcaatggcctctctCtcactgtccctgtgcaggtc	7	12	8	14	0	3	1	2	0	2	1	7	1	4	1	2	2	1	1	2	2	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:89579771C>T	uc001dmz.1	-	7	1348	c.1077G>A	c.(1075-1077)GAG>GAA	p.E359E	GBP2_uc001dmy.1_RNA	NM_004120	NP_004111	P32456	GBP2_HUMAN	guanylate binding protein 2,	359					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)	1		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		TGGCCTCTCTCTCACTGTCCC	0.502													23	97					0	0	0	0	T	89579771	T	T	89579771	2	4	94	1	0	0	0	0	0	0	0	1	6309	912	32	2		2	GBP2	1	89579771	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	42301486	89579771	159670850	7	18181											
SPAG17	200162	broad.mit.edu	37	chr1	118583431	118583431	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaatttgaccctgagatttGagtgggtatatttcccatat	10	16	9	6	0	0	3	0	3	0	1	1	4	1	3	2	1	0	2	2	1	4	7			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:118583431G>C	uc001ehk.2	-	22	3156	c.3088C>G	c.(3088-3090)CAA>GAA	p.Q1030E		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1030						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CCTGAGATTTGAGTGGGTATA	0.363													8	44					0	0	0	0	C	118583431	C	C	118583431	3	2	94	1	0	0	0	0	1	0	0	0	15045	1299	45	2	3691	2	SPAG17	1	118583431	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	29003660	118583431	130667190	8	18182											
PDE4DIP	9659	broad.mit.edu	37	chr1	145015938	145015938	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaggaatatgtctgcacaaaCgggaccttttcaccacttct	12	11	7	11	1	3	0	1	0	2	0	3	2	3	2	2	2	2	1	2	2	4	4	rs144857876	byFrequency	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:145015938C>T	uc001elx.3	-	3	485	c.150G>A	c.(148-150)CCG>CCA	p.P50P	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elm.3_5'UTR|PDE4DIP_uc001eln.3_Silent_p.P50P|PDE4DIP_uc001elo.2_Silent_p.P121P|PDE4DIP_uc001emh.2_Silent_p.P121P|uc001emj.2_Intron	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:Variant_position_missing_in_Q5VU43_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTGCACAAACGGGACCTTTT	0.443			T	PDGFRB	MPD								29	492					0	0	0	0	T	145015938	T	T	145015938	2	4	94	1	0	0	0	0	0	0	0	1	11697	523	19	1		1	PDE4DIP	1	145015938	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	26432507	145015938	104234683	9	18183											
TCHH	7062	broad.mit.edu	37	chr1	152083791	152083791	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctcctgctcctcgctcttCagcagctgctggcgcctctc	2	12	8	19	2	3	0	1	0	2	0	8	0	6	0	4	1	4	5	4	1	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:152083791C>T	uc001ezp.2	-	2	1902	c.1902G>A	c.(1900-1902)CTG>CTA	p.L634L	TCHH_uc009wne.1_Silent_p.L634L	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	634	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCGCTCTTCAGCAGCTGCT	0.672													22	46					0	0	0	0	T	152083791	T	T	152083791	2	4	94	1	0	0	0	0	0	0	0	1	15766	813	29	2		2	TCHH	1	152083791	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	7067853	152083791	97166830	10	18184											
FLG	2312	broad.mit.edu	37	chr1	152277136	152277136	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtggtgggatccttgtcttCgtccagtgctggtcctggtc	2	14	14	11	2	1	0	0	0	1	0	6	1	4	1	3	4	1	1	3	4	0	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:152277136C>T	uc001ezu.1	-	3	10262	c.10226G>A	c.(10225-10227)CGA>CAA	p.R3409Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3409	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTTGTCTTCGTCCAGTGCT	0.602									Ichthyosis				53	169					0	0	0	0	T	152277136	T	T	152277136	3	4	94	1	0	0	0	0	1	0	0	0	5954	884	31	1	1963	1	FLG	1	152277136	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	193345	152277136	96973485	11	18185											
SMG5	23381	broad.mit.edu	37	chr1	156233278	156233278	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accttcggccatcaggacctGaagcttctcctggatgctgc	7	10	10	14	1	2	1	1	1	1	0	4	3	2	3	4	3	3	2	4	3	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:156233278G>A	uc001foc.3	-	13	2088	c.1939C>T	c.(1939-1941)CAG>TAG	p.Q647*	SMG5_uc009wrv.2_Nonsense_Mutation_p.Q132*	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	647					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					ATCAGGACCTGAAGCTTCTCC	0.602													11	97					0	0	0	0	A	156233278	A	A	156233278	4	1	94	1	0	0	0	0	0	1	0	0	14860	1299	45	2	1151	2	SMG5	1	156233278	Nonsense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	3956142	156233278	93017343	12	18186											
ARHGAP30	257106	broad.mit.edu	37	chr1	161024455	161024455	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccgaagcacctctaggatcTtgaccaagcgctcaggttcc	9	8	9	15	2	3	1	1	1	2	0	4	3	4	2	4	2	2	3	4	2	3	3	rs146389701	byFrequency	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:161024455T>C	uc001fxl.2	-	4	732	c.386A>G	c.(385-387)AAG>AGG	p.K129R	ARHGAP30_uc001fxk.2_Missense_Mutation_p.K129R|ARHGAP30_uc001fxm.2_5'UTR|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_5'UTR	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	129	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CTCTAGGATCTTGACCAAGCG	0.527													15	60					0	0	0	0	C	161024455	C	C	161024455	3	2	94	1	0	0	0	0	1	0	0	0	879	1609	56	5	2955	5	ARHGAP30	1	161024455	Missense_Mutation	SNP	T	TCGA-CQ-5327-01A-01D-1683-08	4791177	161024455	88226166	13	18187											
NOS1AP	9722	broad.mit.edu	37	chr1	162326887	162326887	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagctcctccagcagctcctCcagcagcagcagcagcagac	10	4	9	18	0	0	1	0	0	0	1	4	1	4	1	4	0	8	8	4	0	0	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:162326887C>G	uc001gbv.2	+	8	1287	c.900C>G	c.(898-900)CTC>CTG	p.L300L	NOS1AP_uc010pkr.1_Silent_p.L295L|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Silent_p.L295L	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	300					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			agcagctcctccagcagcAGC	0.517													13	45					0	0	0	0	G	162326887	G	G	162326887	2	3	94	1	0	0	0	0	0	0	0	1	10596	842	30	2		2	NOS1AP	1	162326887	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	1302432	162326887	86923734	14	18188											
ABL2	27	broad.mit.edu	37	chr1	179084052	179084052	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccttaggggggcatccctCaggctgttccattcgatatc	8	11	10	12	1	1	0	1	0	0	0	5	1	3	0	3	4	1	3	3	4	3	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:179084052C>T	uc001gmj.3	-	9	1809	c.1522G>A	c.(1522-1524)GAG>AAG	p.E508K	ABL2_uc010pnf.1_Missense_Mutation_p.E508K|ABL2_uc010png.1_Missense_Mutation_p.E487K|ABL2_uc010pnh.1_Missense_Mutation_p.E487K|ABL2_uc009wxe.2_Missense_Mutation_p.E487K|ABL2_uc001gmg.3_Missense_Mutation_p.E493K|ABL2_uc001gmi.3_Missense_Mutation_p.E493K|ABL2_uc001gmh.3_Missense_Mutation_p.E472K|ABL2_uc010pne.1_Missense_Mutation_p.E472K	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	508	Protein kinase.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.H508L(1)		lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GGGCATCCCTCAGGCTGTTCC	0.403			T	ETV6	AML								22	72					0	0	0	0	T	179084052	T	T	179084052	3	4	94	1	0	0	0	0	1	0	0	0	93	835	29	2	2087	2	ABL2	1	179084052	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	16757165	179084052	70166569	15	18189											
TMEM183A	92703	broad.mit.edu	37	chr1	202992016	202992016	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagcacggacatgcggcatCatcgagtgagactggtgttc	9	9	14	9	3	1	2	1	2	0	1	3	5	1	3	0	3	2	3	0	3	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:202992016C>T	uc001gyu.1	+	8	1037	c.979C>T	c.(979-981)CAT>TAT	p.H327Y	TMEM183A_uc001gyv.1_RNA|TMEM183A_uc001gyw.1_Missense_Mutation_p.H326Y|TMEM183A_uc001gyx.1_Missense_Mutation_p.S323L|TMEM183A_uc001gyy.2_5'Flank	NM_001079809	NP_001073277	Q8IXX5	T183A_HUMAN	transmembrane protein 183B	327						integral to membrane					0			BRCA - Breast invasive adenocarcinoma(75;0.18)			CATGCGGCATCATCGAGTGAG	0.488													31	114					0	0	0	0	T	202992016	T	T	202992016	3	4	94	1	0	0	0	0	1	0	0	0	16168	826	29	2	1009	2	TMEM183A	1	202992016	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	23907964	202992016	46258605	16	18190											
AVPR1B	553	broad.mit.edu	37	chr1	206224835	206224835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggccatgacgctggaccGctacctggctgtctgtcacc	5	9	12	15	2	2	1	1	1	1	0	2	2	2	2	4	3	1	4	4	3	1	1	rs41314448		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:206224835G>A	uc001hds.2	+	1	553	c.395G>A	c.(394-396)CGC>CAC	p.R132H		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	132	Cytoplasmic (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	ACGCTGGACCGCTACCTGGCT	0.657													15	62					0	0	0	0	A	206224835	A	A	206224835	3	1	94	1	0	0	0	0	1	0	0	0	1234	1087	38	1	397	1	AVPR1B	1	206224835	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	3232819	206224835	43025786	17	18191											
PTPN14	5784	broad.mit.edu	37	chr1	214556663	214556663	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggacactcaccctgatcatCatctctctctctataatgct	10	13	4	14	0	6	1	3	1	3	0	8	2	6	2	1	1	1	1	1	1	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:214556663C>T	uc001hkk.1	-	13	2806	c.2535G>A	c.(2533-2535)ATG>ATA	p.M845I	PTPN14_uc010pty.1_Missense_Mutation_p.M746I	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	845					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CCCTGATCATCATCTCTCTCT	0.512													18	61					0	0	0	0	T	214556663	T	T	214556663	3	4	94	1	0	0	0	0	1	0	0	0	12846	826	29	2	1056	2	PTPN14	1	214556663	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	8331828	214556663	34693958	18	18192											
IRF2BP2	359948	broad.mit.edu	37	chr1	234743542	234743543	+	Frame_Shift_Ins	INS	-	CC	CC																															tctccgttgatcttagggggINScccgacttcaccttctggtt																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:234743542_234743543insCC	uc001hwg.2	-	2	1135_1136	c.1104_1105insGG	c.(1102-1107)GGGCCCfs	p.G368fs	IRF2BP2_uc009xfw.2_5'UTR|IRF2BP2_uc001hwf.2_Frame_Shift_Ins_p.G352fs	NM_182972	NP_892017	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	368_369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			ATCTTAGGGGGCCCGACTTCAC	0.52													---	---	---								CC	234743543	CC	CC	234743542	7	5	94	1	0	1	1	0	0	0	0	0	7869	1203	42	0	662	0	IRF2BP2	1	234743542	Frame_Shift_Ins	INS	-	TCGA-CQ-5327-01A-01D-1683-08	20186879	234743542	14507079	19	18193											
WDR64	128025	broad.mit.edu	37	chr1	241850813	241850813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgaaaattagatatatttCagccctaaattgttttggat	14	17	6	4	0	1	2	1	1	0	1	1	3	1	3	1	1	1	1	1	1	8	9			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:241850813C>T	uc001hze.1	+	7	1067	c.860C>T	c.(859-861)TCA>TTA	p.S287L	WDR64_uc001hzf.1_Missense_Mutation_p.S7L			B1ANS9	WDR64_HUMAN	RecName: Full=WD repeat-containing protein 64;	287										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			AGATATATTTCAGCCCTAAAT	0.343													20	83					0	0	0	0	T	241850813	T	T	241850813	3	4	94	1	0	0	0	0	1	0	0	0	17383	838	29	2	886	2	WDR64	1	241850813	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	7107271	241850813	7399808	20	18194											
ZNF496	84838	broad.mit.edu	37	chr1	247492661	247492661	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctccttggtgtgcctctCaggccgcagccagcccccgc	3	8	11	19	2	1	0	1	0	1	0	3	0	2	0	6	2	4	2	6	2	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:247492661C>T	uc001ico.2	-	3	685	c.220G>A	c.(220-222)GAG>AAG	p.E74K	ZNF496_uc009xgv.2_Missense_Mutation_p.E74K|ZNF496_uc001icp.2_Missense_Mutation_p.E74K|ZNF496_uc010pyv.1_Missense_Mutation_p.E74K	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	74	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			GTGTGCCTCTCAGGCCGCAGC	0.711													8	29					0	0	0	0	T	247492661	T	T	247492661	3	4	94	1	0	0	0	0	1	0	0	0	18012	835	29	2	1571	2	ZNF496	1	247492661	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	5641848	247492661	1757960	21	18195											
RSAD2	91543	broad.mit.edu	37	chr2	7035928	7035928	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgcgctttctgaactgtaGaaagggacggaaggaccctt	11	9	13	8	2	1	2	0	1	1	1	1	6	1	5	1	3	2	2	1	3	4	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:7035928G>A	uc002qyp.1	+	6	1077	c.941G>A	c.(940-942)AGA>AAA	p.R314K		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	314					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		CTGAACTGTAGAAAGGGACGG	0.378													12	50					0	0	0	0	A	7035928	A	A	7035928	3	1	94	1	0	0	0	0	1	0	0	0	13760	942	33	2	963	2	RSAD2	2	7035928	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		7035928	236163445	22	18196											
NBAS	51594	broad.mit.edu	37	chr2	15519752	15519752	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatccatgcagctatcagtGaggttggtagaagaattgaa	14	10	12	5	0	1	5	1	2	0	3	2	5	2	5	1	2	2	4	1	2	5	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:15519752G>C	uc002rcc.1	-	30	3590	c.3564C>G	c.(3562-3564)CTC>CTG	p.L1188L	NBAS_uc010exl.1_Silent_p.L260L|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1188										ovary(2)|liver(1)|skin(1)	4						AGCTATCAGTGAGGTTGGTAG	0.428													18	49					0	0	0	0	C	15519752	C	C	15519752	2	2	94	1	0	0	0	0	0	0	0	1	10239	1277	45	2		2	NBAS	2	15519752	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	8483824	15519752	227679621	23	18197											
GPR113	165082	broad.mit.edu	37	chr2	26533572	26533572	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacctacctggagggtgttGagaatggtgaagatgtaatg	11	11	14	5	0	1	3	1	2	0	2	1	5	1	4	2	3	1	2	2	3	4	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:26533572G>C	uc002rhe.3	-	11	3024	c.3024C>G	c.(3022-3024)CTC>CTG	p.L1008L	GPR113_uc010yky.1_Silent_p.L939L|GPR113_uc002rhb.1_Silent_p.L611L|GPR113_uc010eyk.1_Silent_p.L809L|GPR113_uc002rhc.1_Silent_p.L611L|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	1008	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGGGTGTTGAGAATGGTGA	0.473													6	10					0	0	0	0	C	26533572	C	C	26533572	2	2	94	1	0	0	0	0	0	0	0	1	6668	1277	45	2		2	GPR113	2	26533572	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	11013820	26533572	216665801	24	18198											
GPR113	165082	broad.mit.edu	37	chr2	26533788	26533788	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagcccattcacgcctatGatggccagcactggccccac	9	6	8	18	1	1	1	1	1	0	0	1	1	1	1	6	2	2	1	6	2	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:26533788G>A	uc002rhe.3	-	11	2808	c.2808C>T	c.(2806-2808)ATC>ATT	p.I936I	GPR113_uc010yky.1_Silent_p.I867I|GPR113_uc002rhb.1_Silent_p.I539I|GPR113_uc010eyk.1_Silent_p.I737I|GPR113_uc002rhc.1_Silent_p.I539I|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	936	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCACGCCTATGATGGCCAGCA	0.597													9	12					0	0	0	0	A	26533788	A	A	26533788	2	1	94	1	0	0	0	0	0	0	0	1	6668	1280	45	2		2	GPR113	2	26533788	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	216	26533788	216665585	25	18199											
SLC4A1AP	22950	broad.mit.edu	37	chr2	27907945	27907945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaactccctccaactctaatGagaatgaaagatgagcctga	15	8	8	10	0	1	5	0	4	1	2	3	7	3	5	3	0	3	0	3	0	5	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:27907945G>A	uc002rlk.3	+	10	2199	c.1917G>A	c.(1915-1917)ATG>ATA	p.M639I		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	639						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					CAACTCTAATGAGAATGAAAG	0.299													18	46					0	0	0	0	A	27907945	A	A	27907945	3	1	94	1	0	0	0	0	1	0	0	0	14717	1290	45	2	1955	2	SLC4A1AP	2	27907945	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1374157	27907945	215291428	26	18200											
SLC4A1AP	22950	broad.mit.edu	37	chr2	27907958	27907958	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctaatgagaatgaaagatGagcctgaagtagaagaggag	17	7	13	4	0	1	7	0	4	1	4	1	9	1	8	1	1	1	1	1	1	6	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:27907958G>A	uc002rlk.3	+	10	2212	c.1930G>A	c.(1930-1932)GAG>AAG	p.E644K		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	644	Glu-rich.					cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					AATGAAAGATGAGCCTGAAGT	0.328													21	42					0	0	0	0	A	27907958	A	A	27907958	3	1	94	1	0	0	0	0	1	0	0	0	14717	1291	45	2	1968	2	SLC4A1AP	2	27907958	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	13	27907958	215291415	27	18201											
LRPPRC	10128	broad.mit.edu	37	chr2	44128664	44128664	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcagtgttgtcacagcctCtaaaatacaagagcaggaga	14	10	9	8	0	3	2	2	0	1	2	3	3	3	2	1	1	3	2	1	1	4	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:44128664C>G	uc002rtr.2	-	32	3423	c.3365_splice	c.e32-1	p.E1122_splice	LRPPRC_uc010yob.1_Intron	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein						mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTCACAGCCTCTAAAATACAA	0.433													8	31					0	0	0	0	G	44128664	G	G	44128664	5	3	94	1	0	0	0	0	0	0	1	0	9015	927	32	2	848	2	LRPPRC	2	44128664	Splice_Site	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	16220706	44128664	199070709	28	18202											
CCDC88A	55704	broad.mit.edu	37	chr2	55561402	55561402	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttcacattattttcttctAatgtggtatctttaatttct	8	23	3	7	0	6	0	1	0	5	0	6	0	6	0	0	1	0	1	0	1	4	10			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:55561402A>T	uc002ryv.2	-	15	3397	c.2555T>A	c.(2554-2556)TTA>TAA	p.L852*	CCDC88A_uc010yoz.1_Nonsense_Mutation_p.L852*|CCDC88A_uc010ypa.1_Nonsense_Mutation_p.L852*|CCDC88A_uc010ypb.1_Nonsense_Mutation_p.L754*|CCDC88A_uc002ryu.2_Nonsense_Mutation_p.L135*|CCDC88A_uc002ryw.2_Nonsense_Mutation_p.L135*	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	852	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						ATTTTCTTCTAATGTGGTATC	0.323													15	70					0	0	0	0	T	55561402	T	T	55561402	4	4	94	1	0	0	0	0	0	1	0	0	2876	372	13	5	3132	5	CCDC88A	2	55561402	Nonsense_Mutation	SNP	A	TCGA-CQ-5327-01A-01D-1683-08	11432738	55561402	187637971	29	18203											
PCBP1	5093	broad.mit.edu	37	chr2	70315832	70315832	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaaaattgccaacccagtGgaaggctcctctggtaggca	12	8	10	11	0	2	0	1	0	1	0	3	1	3	1	3	4	2	3	3	4	5	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:70315832G>A	uc002sgf.2	+	1	1248	c.957G>A	c.(955-957)GTG>GTA	p.V319V	ASPRV1_uc002sga.2_5'Flank|uc002sgb.1_5'Flank|uc002sgd.2_5'Flank|uc002sge.1_5'Flank	NM_006196	NP_006187	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	319	KH 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding				0						CCAACCCAGTGGAAGGCTCCT	0.512													15	34					0	0	0	0	A	70315832	A	A	70315832	2	1	94	1	0	0	0	0	0	0	0	1	11554	1335	47	4		4	PCBP1	2	70315832	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	14754430	70315832	172883541	30	18204											
FBXO41	150726	broad.mit.edu	37	chr2	73492491	73492491	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgggccctcagcctctgactCagtggttcgggagccaacgt	6	8	13	14	3	3	1	2	1	1	0	4	2	3	2	3	3	3	1	3	3	1	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:73492491C>T	uc002sjb.1	-	5	1666	c.1666G>A	c.(1666-1668)GAG>AAG	p.E556K		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	F-box protein 41	495						intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3						GCCTCTGACTCAGTGGTTCGG	0.687													13	40					0	0	0	0	T	73492491	T	T	73492491	3	4	94	1	0	0	0	0	1	0	0	0	5782	835	29	2	1180	2	FBXO41	2	73492491	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	3176659	73492491	169706882	31	18205											
NCAPH	23397	broad.mit.edu	37	chr2	97035190	97035190	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgtcatggctcagaacctCtccatacctctggcttttgc	6	13	7	15	0	4	1	2	0	2	1	5	1	4	1	4	2	3	2	4	2	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:97035190C>G	uc002svz.1	+	17	2202	c.2118C>G	c.(2116-2118)CTC>CTG	p.L706L	NCAPH_uc010yum.1_Silent_p.L682L|NCAPH_uc010fhw.1_Silent_p.L695L|NCAPH_uc010yun.1_Silent_p.L570L|NCAPH_uc002swa.1_Silent_p.L301L	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	706					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				CTCAGAACCTCTCCATACCTC	0.433													33	100					0	0	0	0	G	97035190	G	G	97035190	2	3	94	1	0	0	0	0	0	0	0	1	10263	900	32	2		2	NCAPH	2	97035190	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	23542699	97035190	146164183	32	18206											
NCAPH	23397	broad.mit.edu	37	chr2	97035215	97035215	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacctctggcttttgcctgtCtcctacatttagccaatgaa	8	15	6	12	0	2	1	0	1	2	0	3	1	2	1	4	1	4	1	4	1	5	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:97035215C>G	uc002svz.1	+	17	2227	c.2143C>G	c.(2143-2145)CTC>GTC	p.L715V	NCAPH_uc010yum.1_Missense_Mutation_p.L691V|NCAPH_uc010fhw.1_Missense_Mutation_p.L704V|NCAPH_uc010yun.1_Missense_Mutation_p.L579V|NCAPH_uc002swa.1_Missense_Mutation_p.L310V	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	715					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				TTTTGCCTGTCTCCTACATTT	0.428													34	105					0	0	0	0	G	97035215	G	G	97035215	3	3	94	1	0	0	0	0	1	0	0	0	10263	913	32	2	2209	2	NCAPH	2	97035215	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	25	97035215	146164158	33	18207											
TBC1D8	11138	broad.mit.edu	37	chr2	101624355	101624355	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttttgagattgtactgattGatcttggcattttcaagttt	8	20	9	4	0	2	3	1	3	1	1	2	4	2	3	0	1	1	4	0	1	2	9			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:101624355G>A	uc010fiv.2	-	20	3482	c.3351C>T	c.(3349-3351)ATC>ATT	p.I1117I	RPL31_uc010yvu.1_Intron|RPL31_uc010yvv.1_Intron|RPL31_uc010fiu.1_Intron|TBC1D8_uc002tau.3_Silent_p.I874I	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	1117				I -> T (in Ref. 4; BAF85515).	blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						TGTACTGATTGATCTTGGCAT	0.383													39	129					0	0	0	0	A	101624355	A	A	101624355	2	1	94	1	0	0	0	0	0	0	0	1	15691	1280	45	2		2	TBC1D8	2	101624355	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	4589140	101624355	141575018	34	18208											
LCT	3938	broad.mit.edu	37	chr2	136590728	136590728	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagcaggagctccgggatatCttcagctcgcaggacaacag	11	7	12	11	2	2	0	1	0	1	0	4	3	3	3	1	3	4	4	1	3	3	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:136590728C>G	uc002tuu.1	-	2	684	c.673G>C	c.(673-675)GAT>CAT	p.D225H		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	225	Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCCGGGATATCTTCAGCTCGC	0.517													33	115					0	0	0	0	G	136590728	G	G	136590728	3	3	94	1	0	0	0	0	1	0	0	0	8733	913	32	2	5174	2	LCT	2	136590728	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	34966373	136590728	106608645	35	18209											
KYNU	8942	broad.mit.edu	37	chr2	143799685	143799685	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataattctttccatgatgttTataaatttaccaatctgctc	12	18	3	8	0	2	1	0	1	2	0	4	1	3	1	2	0	2	2	2	0	6	8			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:143799685T>C	uc002tvl.2	+	14	1472	c.1342T>C	c.(1342-1344)TAT>CAT	p.Y448H	KYNU_uc010fnm.2_Missense_Mutation_p.Y448H	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	448					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	ccatgatgtttataaaTTTAC	0.284													13	63					0	0	0	0	C	143799685	C	C	143799685	3	2	94	1	0	0	0	0	1	0	0	0	8627	1754	61	5	1418	5	KYNU	2	143799685	Missense_Mutation	SNP	T	TCGA-CQ-5327-01A-01D-1683-08	7208957	143799685	99399688	36	18210											
PLA2R1	22925	broad.mit.edu	37	chr2	160826691	160826692	+	Frame_Shift_Ins	INS	-	C	C																															tggctctttcttcttgaagtINSccaatccaccaacttgcacc																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:160826691_160826692insC	uc002ube.1	-	18	2834_2835	c.2627_2628insG	c.(2626-2628)GGAfs	p.G876fs	PLA2R1_uc010zcp.1_Frame_Shift_Ins_p.G876fs|PLA2R1_uc002ubf.2_Frame_Shift_Ins_p.G876fs	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	876	Extracellular (Potential).|C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CTTCTTGAAGTCCAATCCACCA	0.322													---	---	---								C	160826692	C	C	160826691	7	5	94	1	0	1	1	0	0	0	0	0	12065	1654	58	0	1823	0	PLA2R1	2	160826691	Frame_Shift_Ins	INS	-	TCGA-CQ-5327-01A-01D-1683-08	17027006	160826691	82372682	37	18211											
SLC4A10	57282	broad.mit.edu	37	chr2	162820729	162820729	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcacgtaccgcttcgaaaaGtgcatctcttcacaattatt	11	12	7	11	3	2	0	1	0	1	0	4	1	2	0	1	1	2	4	1	1	5	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:162820729G>T	uc002ubx.3	+	22	3131	c.2947G>T	c.(2947-2949)GTG>TTG	p.V983L	SLC4A10_uc002uby.3_Missense_Mutation_p.V953L|SLC4A10_uc010zcs.1_Missense_Mutation_p.V964L	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	983	Extracellular (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						GCTTCGAAAAGTGCATCTCTT	0.378													8	25					1.06961e-07	1.12943e-07	1	0	T	162820729	T	T	162820729	3	4	94	1	0	0	0	0	1	0	0	0	14715	1029	36	4	3118	4	SLC4A10	2	162820729	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1994038	162820729	80378644	38	18212											
KBTBD10	10324	broad.mit.edu	37	chr2	170377507	170377507	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcacccactgaagtcaatGacatatggaagtaagttctc	13	11	8	9	0	2	2	1	2	1	0	3	3	2	3	1	1	1	3	1	1	5	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:170377507G>C	uc002ueu.1	+	5	1776	c.1699G>C	c.(1699-1701)GAC>CAC	p.D567H	KBTBD10_uc010zdh.1_Missense_Mutation_p.D505H	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	567	Kelch 5.				striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						TGAAGTCAATGACATATGGAA	0.338													8	62					0	0	0	0	C	170377507	C	C	170377507	3	2	94	1	0	0	0	0	1	0	0	0	8029	1290	45	2	1717	2	KBTBD10	2	170377507	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	7556778	170377507	72821866	39	18213											
TTN	7273	broad.mit.edu	37	chr2	179427277	179427277	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggtgggaggggtggttcaGacactttaacgggttctgtt	7	12	16	6	1	2	1	1	0	1	1	2	2	2	2	0	6	1	3	0	6	1	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:179427277G>C	uc010zfg.1	-	275	76102	c.75878C>G	c.(75877-75879)TCT>TGT	p.S25293C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S18988C|TTN_uc010zfi.1_Missense_Mutation_p.S18921C|TTN_uc010zfj.1_Missense_Mutation_p.S18796C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26220							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTGGTTCAGACACTTTAAC	0.443													10	48					0	0	0	0	C	179427277	C	C	179427277	3	2	94	1	0	0	0	0	1	0	0	0	16803	942	33	2	24545	2	TTN	2	179427277	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	9049770	179427277	63772096	40	18214											
TTN	7273	broad.mit.edu	37	chr2	179638442	179638442	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatcttttagaggtgttatCacgtccacacctgcaaaatc	12	12	6	11	1	2	1	1	0	1	1	4	1	3	1	2	1	1	2	2	1	4	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:179638442C>G	uc010zfg.1	-	32	7565	c.7341G>C	c.(7339-7341)GTG>GTC	p.V2447V	TTN_uc010zfh.1_Silent_p.V2401V|TTN_uc010zfi.1_Silent_p.V2401V|TTN_uc010zfj.1_Silent_p.V2401V|TTN_uc002unb.2_Silent_p.V2447V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2447							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGGTGTTATCACGTCCACAC	0.373													8	53					0	0	0	0	G	179638442	G	G	179638442	2	3	94	1	0	0	0	0	0	0	0	1	16803	813	29	2		2	TTN	2	179638442	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	211165	179638442	63560931	41	18215											
ZNF804A	91752	broad.mit.edu	37	chr2	185801352	185801352	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tactgaagaggttaacataaCtatacataagaaaacaaatt	21	10	5	5	0	0	3	0	1	0	2	0	3	0	3	0	1	5	1	0	1	10	7			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:185801352C>A	uc002uph.2	+	4	1823	c.1229C>A	c.(1228-1230)ACT>AAT	p.T410N		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	410						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GTTAACATAACTATACATAAG	0.383													23	68					4.54149e-19	4.95856e-19	1	0	A	185801352	A	A	185801352	3	1	94	1	0	0	0	0	1	0	0	0	18237	565	20	4	1243	4	ZNF804A	2	185801352	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	6162910	185801352	57398021	42	18216											
HIBCH	26275	broad.mit.edu	37	chr2	191155142	191155142	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacacataccaacagcattaTtcagcatatattcttctctg	13	14	3	11	0	3	0	1	0	2	0	4	0	3	0	1	0	5	2	1	0	6	8			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:191155142T>C	uc002uru.2	-	5	457	c.374A>G	c.(373-375)AAT>AGT	p.N125S	HIBCH_uc002urv.2_Missense_Mutation_p.N125S	NM_014362	NP_055177	Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-Coenzyme A hydrolase isoform	125					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			AACAGCATTATTCAGCATATA	0.343													15	28					0	0	0	0	C	191155142	C	C	191155142	3	2	94	1	0	0	0	0	1	0	0	0	7139	1493	52	5	826	5	HIBCH	2	191155142	Missense_Mutation	SNP	T	TCGA-CQ-5327-01A-01D-1683-08	5353790	191155142	52044231	43	18217											
SGOL2	151246	broad.mit.edu	37	chr2	201436564	201436564	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagaaaagaataacaaatGagcaagaggaaacatactct	22	5	9	5	0	1	4	0	1	1	3	1	6	1	5	0	2	4	1	0	2	8	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:201436564G>A	uc002uvw.2	+	7	1608	c.1495G>A	c.(1495-1497)GAG>AAG	p.E499K	SGOL2_uc010zhd.1_Missense_Mutation_p.E499K|SGOL2_uc010zhe.1_Missense_Mutation_p.E499K	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	499					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						AATAACAAATGAGCAAGAGGA	0.338													23	129					0	0	0	0	A	201436564	A	A	201436564	3	1	94	1	0	0	0	0	1	0	0	0	14282	1291	45	2	1517	2	SGOL2	2	201436564	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	10281422	201436564	41762809	44	18218											
CASP8	841	broad.mit.edu	37	chr2	202131502	202131505	+	Frame_Shift_Del	DEL	TTTC	-	-																															gacaccaggcagggctcaaaTttctgcctacaggtgggtgg																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:202131502_202131505delTTTC	uc002uxr.1	+	3	502_505	c.293_296delTTTC	c.(292-297)ATTTCTfs	p.I98fs	CASP8_uc010ftc.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxo.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxp.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxq.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxs.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxt.1_Frame_Shift_Del_p.I157fs|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxw.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxy.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxx.1_Frame_Shift_Del_p.I98fs|CASP8_uc010ftf.2_Frame_Shift_Del_p.I98fs	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	98_99					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						AGGGCTCAAATTTCTGCCTACAGG	0.495										HNSCC(4;0.00038)			---	---	---								-	202131505	-	-	202131502	7	5	94	1	0	1	0	1	0	0	0	0	2689	1493	52	0	476	0	CASP8	2	202131502	Frame_Shift_Del	DEL	TTTC	TCGA-CQ-5327-01A-01D-1683-08	694938	202131502	41067871	45	18219											
ANKZF1	55139	broad.mit.edu	37	chr2	220098944	220098944	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaagaagcctactgaggaaGaaataagaaagatctgcagg	19	5	12	5	0	1	5	0	1	1	4	1	7	1	6	1	2	3	1	1	2	7	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:220098944G>A	uc002vkg.2	+	9	1312	c.1138G>A	c.(1138-1140)GAA>AAA	p.E380K	ANKZF1_uc010zkv.1_Missense_Mutation_p.E324K|ANKZF1_uc010zkw.1_Missense_Mutation_p.E170K|ANKZF1_uc002vkh.2_Missense_Mutation_p.E170K|ANKZF1_uc002vki.2_Missense_Mutation_p.E380K|ANKZF1_uc002vkj.1_Missense_Mutation_p.E368K	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	380						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TACTGAGGAAGAAATAAGAAA	0.468													9	51					0	0	0	0	A	220098944	A	A	220098944	3	1	94	1	0	0	0	0	1	0	0	0	693	943	33	2	1168	2	ANKZF1	2	220098944	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	17967442	220098944	23100429	46	18220											
SH3BP4	23677	broad.mit.edu	37	chr2	235962446	235962446	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcagccctgcggaccaggacGacttcgtgatttgaatgggt	8	10	13	10	3	1	2	1	2	0	0	2	5	1	4	2	3	2	0	2	3	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:235962446G>A	uc002vvp.2	+	6	3271	c.2878G>A	c.(2878-2880)GAC>AAC	p.D960N	SH3BP4_uc010fym.2_Missense_Mutation_p.D942N|SH3BP4_uc002vvq.2_Missense_Mutation_p.D960N	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	960					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GGACCAGGACGACTTCGTGAT	0.622													10	72					0	0	0	0	A	235962446	A	A	235962446	3	1	94	1	0	0	0	0	1	0	0	0	14311	1058	37	1	2892	1	SH3BP4	2	235962446	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	15863502	235962446	7236927	47	18221											
BHLHE40	8553	broad.mit.edu	37	chr3	5025027	5025027	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accggatgcagctttcggatGatgaaggccatttcactagc	10	10	11	10	2	1	2	1	2	0	0	2	4	1	4	2	3	3	2	2	3	2	3	rs141865687		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:5025027G>A	uc003bqf.2	+	5	1196	c.889G>A	c.(889-891)GAT>AAT	p.D297N	BHLHE40_uc011asw.1_Missense_Mutation_p.D157N	NM_003670	NP_003661	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	297						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCTTTCGGATGATGAAGGCCA	0.562													9	62					0	0	0	0	A	5025027	A	A	5025027	3	1	94	1	0	0	0	0	1	0	0	0	1426	1290	45	2	907	2	BHLHE40	3	5025027	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		5025027	192997403	48	18222											
FBLN2	2199	broad.mit.edu	37	chr3	13655526	13655526	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggcctccgcgtgcgggccGagggccagtcgtgtgagtcc	3	7	18	13	5	0	1	0	1	0	0	3	2	2	1	5	3	1	0	5	3	0	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:13655526G>A	uc011avb.1	+	5	1716	c.1591G>A	c.(1591-1593)GAG>AAG	p.E531K	FBLN2_uc011auz.1_Missense_Mutation_p.E557K|FBLN2_uc011ava.1_Missense_Mutation_p.E531K|FBLN2_uc011avc.1_Missense_Mutation_p.E531K|uc003byc.1_5'Flank	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	531	Anaphylatoxin-like 3.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CGTGCGGGCCGAGGGCCAGTC	0.597													12	41					0	0	0	0	A	13655526	A	A	13655526	3	1	94	1	0	0	0	0	1	0	0	0	5731	1059	37	1	295	1	FBLN2	3	13655526	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	8630499	13655526	184366904	49	18223											
EPM2AIP1	9852	broad.mit.edu	37	chr3	37034418	37034418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggcgcctgacgtcgcgttCgcgggtagctacgatgaggc	5	8	17	11	7	0	2	0	2	0	0	2	3	0	2	1	3	2	3	1	3	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:37034418C>T	uc003cgk.2	-	1	378	c.151G>A	c.(151-153)GAA>AAA	p.E51K	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	51						endoplasmic reticulum					0						ACGTCGCGTTCGCGGGTAGCT	0.677													9	30					0	0	0	0	T	37034418	T	T	37034418	3	4	94	1	0	0	0	0	1	0	0	0	5208	893	31	1	1676	1	EPM2AIP1	3	37034418	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	23378892	37034418	160988012	50	18224											
OXSR1	9943	broad.mit.edu	37	chr3	38266161	38266161	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatcatttagaaaaatgAtttcattgtgccttcaaaaa	18	13	5	5	0	3	2	3	1	0	1	3	3	3	2	1	0	1	0	1	0	7	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:38266161A>C	uc003chy.2	+	8	1144	c.802A>C	c.(802-804)ATT>CTT	p.I268L	OXSR1_uc010hhb.2_Missense_Mutation_p.I202L|OXSR1_uc010hha.1_Missense_Mutation_p.I200L	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	268	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TAGAAAAATGATTTCATTGTG	0.313													13	24					0	0	0	0	C	38266161	C	C	38266161	3	2	94	1	0	0	0	0	1	0	0	0	11390	333	12	5	832	5	OXSR1	3	38266161	Missense_Mutation	SNP	A	TCGA-CQ-5327-01A-01D-1683-08	1231743	38266161	159756269	51	18225											
XIRP1	165904	broad.mit.edu	37	chr3	39228921	39228921	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggccgtcttccacagggacgGcctgaggcctgaagaggctc	7	6	15	13	2	1	3	0	2	1	1	3	4	2	4	4	5	0	1	4	5	1	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:39228921G>A	uc003cjk.1	-	2	2237	c.2016C>T	c.(2014-2016)GGC>GGT	p.G672G	XIRP1_uc003cji.2_Silent_p.G672G|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	672							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CACAGGGACGGCCTGAGGCCT	0.612													12	54					0	0	0	0	A	39228921	A	A	39228921	2	1	94	1	0	0	0	0	0	0	0	1	17497	1190	42	4		4	XIRP1	3	39228921	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	962760	39228921	158793509	52	18226											
CCDC51	79714	broad.mit.edu	37	chr3	48475178	48475178	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgtcctccctggagacaCggtccaagcggtccctcacc	7	7	10	17	2	1	1	1	0	0	1	5	3	5	1	5	3	1	0	5	3	1	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:48475178C>A	uc003csz.2	-	3	537	c.416G>T	c.(415-417)CGT>CTT	p.R139L	CCDC51_uc003cta.2_Missense_Mutation_p.R30L|CCDC51_uc003ctb.2_Missense_Mutation_p.R30L|CCDC51_uc003ctc.2_Missense_Mutation_p.R139L|CCDC51_uc003ctd.2_Missense_Mutation_p.R30L	NM_024661	NP_078937	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	139	Potential.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CCTGGAGACACGGTCCAAGCG	0.597													35	88					3.90053e-15	4.2443e-15	1	0	A	48475178	A	A	48475178	3	1	94	1	0	0	0	0	1	0	0	0	2834	536	19	3	827	3	CCDC51	3	48475178	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	9246257	48475178	149547252	53	18227											
CACNA1D	776	broad.mit.edu	37	chr3	53839030	53839030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaaaactatggctactacaGcagatacccaggcagaaaca	17	5	8	11	0	0	2	0	0	0	2	0	2	0	2	1	2	6	4	1	2	7	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:53839030G>A	uc003dgv.3	+	45	5769	c.5606G>A	c.(5605-5607)AGC>AAC	p.S1869N	CACNA1D_uc003dgu.3_Missense_Mutation_p.S1889N|CACNA1D_uc003dgy.3_Missense_Mutation_p.S1845N|CACNA1D_uc003dgw.3_Missense_Mutation_p.S1536N|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1869	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGCTACTACAGCAGATACCCA	0.522													14	42					0	0	0	0	A	53839030	A	A	53839030	3	1	94	1	0	0	0	0	1	0	0	0	2553	971	34	4	5956	4	CACNA1D	3	53839030	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	5363852	53839030	144183400	54	18228											
PRICKLE2	166336	broad.mit.edu	37	chr3	64084754	64084754	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatacagtttttgctcttCtgtcttttcctgctgtgcaa	6	19	7	9	0	3	1	0	1	3	0	4	1	4	1	1	0	4	4	1	0	2	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:64084754C>A	uc003dmf.2	-	8	3094	c.2508G>T	c.(2506-2508)CAG>CAT	p.Q836H		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	836						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		TTTTGCTCTTCTGTCTTTTCC	0.438													29	72					9.39395e-14	1.01531e-13	1	0	A	64084754	A	A	64084754	3	1	94	1	0	0	0	0	1	0	0	0	12549	912	32	2	30	2	PRICKLE2	3	64084754	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	10245724	64084754	133937676	55	18229											
ADAMTS9	56999	broad.mit.edu	37	chr3	64619398	64619398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actgtatttagggacccagcGcacattgggaagcagaccgt	11	8	12	10	2	0	1	0	0	0	1	0	3	0	3	2	2	2	3	2	2	3	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:64619398G>A	uc003dmg.2	-	13	2046	c.2014C>T	c.(2014-2016)CGC>TGC	p.R672C	ADAMTS9_uc011bfo.1_Missense_Mutation_p.R644C|ADAMTS9_uc003dmh.1_Missense_Mutation_p.R501C|ADAMTS9_uc003dmk.1_Missense_Mutation_p.R672C	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	672	Cys-rich.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGGACCCAGCGCACATTGGGA	0.512													43	225					0	0	0	0	A	64619398	A	A	64619398	3	1	94	1	0	0	0	0	1	0	0	0	273	1087	38	1	3901	1	ADAMTS9	3	64619398	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	534644	64619398	133403032	56	18230											
POLQ	10721	broad.mit.edu	37	chr3	121207251	121207251	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgaaggaaggggttctttCatttgcatatcaggtaattg	10	15	11	5	0	4	1	2	1	2	0	4	2	4	2	0	4	1	3	0	4	4	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:121207251C>T	uc003eee.3	-	16	4656	c.4527G>A	c.(4525-4527)ATG>ATA	p.M1509I	POLQ_uc003eed.2_Missense_Mutation_p.M681I	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1509					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		GGGGTTCTTTCATTTGCATAT	0.318								DNA_polymerases_(catalytic_subunits)					18	58					0	0	0	0	T	121207251	T	T	121207251	3	4	94	1	0	0	0	0	1	0	0	0	12263	826	29	2	3305	2	POLQ	3	121207251	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	56587853	121207251	76815179	57	18231											
POLQ	10721	broad.mit.edu	37	chr3	121207996	121207996	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcactgggtatcacagttCtgcttatatcatctcctaat	9	16	5	11	0	5	0	3	0	2	0	6	0	5	0	1	1	1	3	1	1	4	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:121207996C>T	uc003eee.3	-	16	3911	c.3782G>A	c.(3781-3783)AGA>AAA	p.R1261K	POLQ_uc003eed.2_Missense_Mutation_p.R433K	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1261					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TATCACAGTTCTGCTTATATC	0.343								DNA_polymerases_(catalytic_subunits)					38	151					0	0	0	0	T	121207996	T	T	121207996	3	4	94	1	0	0	0	0	1	0	0	0	12263	913	32	2	4050	2	POLQ	3	121207996	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	745	121207996	76814434	58	18232											
KALRN	8997	broad.mit.edu	37	chr3	123987636	123987636	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacaaagctggtggacccctCccagctgacggaggagtttg	9	7	13	12	1	0	1	0	1	0	0	1	4	1	4	3	4	2	3	3	4	1	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:123987636C>T	uc003ehg.2	+	5	624	c.497C>T	c.(496-498)TCC>TTC	p.S166F	KALRN_uc010hrv.1_Missense_Mutation_p.S166F|KALRN_uc003ehf.1_Missense_Mutation_p.S166F|KALRN_uc011bjy.1_Missense_Mutation_p.S166F	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	166	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GTGGACCCCTCCCAGCTGACG	0.577													8	47					0	0	0	0	T	123987636	T	T	123987636	3	4	94	1	0	0	0	0	1	0	0	0	8014	855	30	2	515	2	KALRN	3	123987636	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	2779640	123987636	74034794	59	18233											
KALRN	8997	broad.mit.edu	37	chr3	124380748	124380748	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaacgctgcaatgacatgatGaatctaggacgtctgcaggg	13	8	12	8	2	2	3	0	3	2	0	2	4	2	4	0	2	3	3	0	2	4	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:124380748G>A	uc003ehg.2	+	45	6442	c.6315G>A	c.(6313-6315)ATG>ATA	p.M2105I	KALRN_uc003ehi.2_Missense_Mutation_p.M446I|KALRN_uc003ehk.2_Missense_Mutation_p.M408I|KALRN_uc011bjz.1_Missense_Mutation_p.M197I	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2104					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ATGACATGATGAATCTAGGAC	0.507													28	89					0	0	0	0	A	124380748	A	A	124380748	3	1	94	1	0	0	0	0	1	0	0	0	8014	1290	45	2	6649	2	KALRN	3	124380748	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	393112	124380748	73641682	60	18234											
ARMC8	25852	broad.mit.edu	37	chr3	137942337	137942337	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaaaacaatgtcaagtctCtactggactgccatattatc	13	12	6	10	0	2	1	1	1	1	0	4	2	2	2	1	1	3	0	1	1	7	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:137942337C>G	uc003esa.1	+	5	626	c.259C>G	c.(259-261)CTA>GTA	p.L87V	ARMC8_uc003erw.2_Missense_Mutation_p.L87V|ARMC8_uc003erx.2_Missense_Mutation_p.L87V|ARMC8_uc003ery.2_Missense_Mutation_p.L59V|ARMC8_uc003erz.2_Missense_Mutation_p.L59V|ARMC8_uc011bmf.1_Missense_Mutation_p.L101V|ARMC8_uc011bmg.1_Missense_Mutation_p.L101V|ARMC8_uc011bmh.1_Missense_Mutation_p.L59V|ARMC8_uc003esb.1_Missense_Mutation_p.L59V	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	101	ARM 2.						binding				0						TGTCAAGTCTCTACTGGACTG	0.413													20	78					0	0	0	0	G	137942337	G	G	137942337	3	3	94	1	0	0	0	0	1	0	0	0	959	912	32	2	273	2	ARMC8	3	137942337	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	13561589	137942337	60080093	61	18235											
CPB1	1360	broad.mit.edu	37	chr3	148563304	148563304	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccctggctgatttcatccGcaacaaactctcttccatca	9	11	6	15	1	3	1	2	1	1	0	6	1	5	1	3	2	2	2	3	2	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:148563304G>A	uc003ewl.2	+	9	895	c.872G>A	c.(871-873)CGC>CAC	p.R291H		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	291					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			GATTTCATCCGCAACAAACTC	0.463													27	70					0	0	0	0	A	148563304	A	A	148563304	3	1	94	1	0	0	0	0	1	0	0	0	3811	1087	38	1	906	1	CPB1	3	148563304	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	10620967	148563304	49459126	62	18236											
SOX2	6657	broad.mit.edu	37	chr3	181430864	181430864	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccctggcatggctcttggctCcatgggttcggtggtcaagt	4	12	14	11	1	2	0	1	0	1	0	4	0	3	0	2	6	0	4	2	6	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:181430864C>A	uc003fkx.2	+	1	1143	c.716C>A	c.(715-717)TCC>TAC	p.S239Y	SOX2OT_uc003fkv.2_Intron|SOX2OT_uc003fkw.3_Intron	NM_003106	NP_003097	P48431	SOX2_HUMAN	sex-determining region Y-box 2	239					cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			GCTCTTGGCTCCATGGGTTCG	0.652			A		NSCLC|oesophageal squamous carcinoma		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						18	61					9.16793e-09	9.71256e-09	1	0	A	181430864	A	A	181430864	3	1	94	1	0	0	0	0	1	0	0	0	15013	855	30	2	718	2	SOX2	3	181430864	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	32867560	181430864	16591566	63	18237											
ABCF3	55324	broad.mit.edu	37	chr3	183910898	183910898	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccttttccagggcggcctGaggaggagtaccgtcaccag	7	8	14	12	2	1	1	1	1	0	0	3	3	3	3	5	4	1	1	5	4	1	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:183910898G>A	uc003fmz.2	+	19	1892	c.1759G>A	c.(1759-1761)GAG>AAG	p.E587K	ABCF3_uc003fna.2_Missense_Mutation_p.E581K|ABCF3_uc003fnb.2_Missense_Mutation_p.E268K	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	587	ABC transporter 2.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGGCGGCCTGAGGAGGAGTA	0.632													12	39					0	0	0	0	A	183910898	A	A	183910898	3	1	94	1	0	0	0	0	1	0	0	0	67	1291	45	2	1833	2	ABCF3	3	183910898	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	2480034	183910898	14111532	64	18238											
CHRD	8646	broad.mit.edu	37	chr3	184100495	184100495	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcatcaccctgctcactctCagtgacacagaggactcctt	9	9	8	15	0	3	2	3	1	1	1	5	3	4	3	2	2	1	2	2	2	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:184100495C>T	uc003fov.2	+	8	1161	c.915C>T	c.(913-915)CTC>CTT	p.L305L	CHRD_uc003fow.2_5'UTR|CHRD_uc003fox.2_Silent_p.L305L|CHRD_uc003foy.2_5'UTR|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'UTR	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	305	CHRD 2.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCTCACTCTCAGTGACACAG	0.592													24	93					0	0	0	0	T	184100495	T	T	184100495	2	4	94	1	0	0	0	0	0	0	0	1	3387	813	29	2		2	CHRD	3	184100495	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	189597	184100495	13921935	65	18239											
LSG1	55341	broad.mit.edu	37	chr3	194362875	194362875	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttttttccagggcttcccCgccccgttctcagagctcgc	3	13	9	16	3	1	1	1	0	1	1	5	1	3	1	5	1	1	4	5	1	0	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:194362875C>T	uc003fui.2	-	14	2214	c.1899G>A	c.(1897-1899)GCG>GCA	p.A633A		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	633					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		AGGGCTTCCCCGCCCCGTTCT	0.498													21	74					0	0	0	0	T	194362875	T	T	194362875	2	4	94	1	0	0	0	0	0	0	0	1	9099	639	23	1		1	LSG1	3	194362875	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	10262380	194362875	3659555	66	18240											
NCBP2	22916	broad.mit.edu	37	chr3	196664450	196664450	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgtcccagtctgtgcgaatGattcggtcatccagacgcgt	7	10	12	12	5	2	2	1	1	1	1	5	3	4	2	2	1	1	0	2	1	1	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:196664450G>C	uc003fxd.1	-	3	420	c.330C>G	c.(328-330)ATC>ATG	p.I110M	NCBP2_uc003fxb.1_Missense_Mutation_p.I40M|NCBP2_uc011btz.1_Missense_Mutation_p.I92M|NCBP2_uc003fxc.1_RNA|NCBP2_uc003fxe.1_Missense_Mutation_p.I57M|NCBP2_uc003fxf.2_3'UTR	NM_007362	NP_031388	P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	110	RRM.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding				0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		CTGTGCGAATGATTCGGTCAT	0.532													25	69					0	0	0	0	C	196664450	C	C	196664450	3	2	94	1	0	0	0	0	1	0	0	0	10266	1280	45	2	148	2	NCBP2	3	196664450	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	2301575	196664450	1357980	67	18241											
SH3TC1	54436	broad.mit.edu	37	chr4	8230222	8230222	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaggccgtgcggctgttctCgaggctgccccttggggagt	3	9	18	11	3	1	0	0	0	1	0	2	3	1	2	3	6	2	3	3	6	0	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:8230222C>T	uc003gkv.3	+	12	2902	c.2801C>T	c.(2800-2802)TCG>TTG	p.S934L	SH3TC1_uc003gkw.3_Missense_Mutation_p.S858L|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	934							binding			large_intestine(2)|pancreas(1)	3						CGGCTGTTCTCGAGGCTGCCC	0.711													12	27					0	0	0	0	T	8230222	T	T	8230222	3	4	94	1	0	0	0	0	1	0	0	0	14326	893	31	1	2843	1	SH3TC1	4	8230222	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08		8230222	182924054	68	18242											
LCORL	254251	broad.mit.edu	37	chr4	17847407	17847407	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcgttagagatgctgttgtCaaattcagattccattcaat	11	15	7	8	1	3	2	3	0	0	2	5	3	4	2	1	0	1	3	1	0	3	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:17847407C>G	uc003gpq.2	-	7	905	c.894G>C	c.(892-894)TTG>TTC	p.L298F	LCORL_uc011bxk.1_3'UTR	NM_153686	NP_710153	Q8N3X6	LCORL_HUMAN	ligand dependent nuclear receptor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						ATGCTGTTGTCAAATTCAGAT	0.383													30	71					0	0	0	0	G	17847407	G	G	17847407	3	3	94	1	0	0	0	0	1	0	0	0	8730	825	29	2	66	2	LCORL	4	17847407	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	9617185	17847407	173306869	69	18243											
ARAP2	116984	broad.mit.edu	37	chr4	36230305	36230305	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaacttgctacgacttctCacaggtgctaggattggtga	10	11	10	10	1	1	1	1	1	1	0	2	3	1	2	1	3	4	2	1	3	3	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:36230305C>G	uc003gsq.1	-	2	1142	c.804G>C	c.(802-804)GTG>GTC	p.V268V	ARAP2_uc003gsr.1_Silent_p.V268V	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	268					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TACGACTTCTCACAGGTGCTA	0.418													24	91					0	0	0	0	G	36230305	G	G	36230305	2	3	94	1	0	0	0	0	0	0	0	1	839	813	29	2		2	ARAP2	4	36230305	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	18382898	36230305	154923971	70	18244											
GABRG1	2565	broad.mit.edu	37	chr4	46043203	46043203	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacactgatacccataatcAtcttcttgcggcacagaaat	15	10	5	11	1	3	2	1	1	2	1	3	2	3	2	1	1	3	1	1	1	4	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:46043203A>G	uc003gxb.2	-	9	1352	c.1200T>C	c.(1198-1200)GAT>GAC	p.D400D		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	400	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		ACCCATAATCATCTTCTTGCG	0.423													16	37					0	0	0	0	G	46043203	G	G	46043203	2	3	94	1	0	0	0	0	0	0	0	1	6205	214	8	5		5	GABRG1	4	46043203	Silent	SNP	A	TCGA-CQ-5327-01A-01D-1683-08	9812898	46043203	145111073	71	18245											
KDR	3791	broad.mit.edu	37	chr4	55968137	55968137	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcaggtgtagaggccttcGtcctccttcctcactctgcg	4	12	11	14	2	2	1	1	0	1	1	6	1	5	1	4	3	1	2	4	3	1	3	rs138304068		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:55968137G>A	uc003has.2	-	15	2495	c.2193C>T	c.(2191-2193)GAC>GAT	p.D731D	KDR_uc003hat.1_Silent_p.D731D	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	731	Ig-like C2-type 7.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGAGGCCTTCGTCCTCCTTCC	0.418			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			18	65					0	0	0	0	A	55968137	A	A	55968137	2	1	94	1	0	0	0	0	0	0	0	1	8178	1136	40	1		1	KDR	4	55968137	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	9924934	55968137	135186139	72	18246											
CLOCK	9575	broad.mit.edu	37	chr4	56310880	56310880	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgccgatgaatatttgcttCtatcatgcgtgtccgttgtt	6	18	9	8	3	2	1	1	1	1	0	3	2	3	1	2	0	3	3	2	0	3	7			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:56310880C>G	uc003haz.1	-	20	2538	c.1612G>C	c.(1612-1614)GAA>CAA	p.E538Q	CLOCK_uc003hba.1_Missense_Mutation_p.E538Q|CLOCK_uc010igu.1_RNA	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	538	Implicated in the circadian rhythmicity (By similarity).				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			ATATTTGCTTCTATCATGCGT	0.388													13	50					0	0	0	0	G	56310880	G	G	56310880	3	3	94	1	0	0	0	0	1	0	0	0	3564	922	32	2	948	2	CLOCK	4	56310880	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	342743	56310880	134843396	73	18247											
ADAMTS3	9508	broad.mit.edu	37	chr4	73414358	73414358	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatattcccaggcaccagaGatgtctcatgccactccaca	11	10	6	14	0	1	1	1	0	1	1	4	2	3	1	4	1	1	1	4	1	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:73414358G>C	uc003hgk.1	-	3	378	c.341C>G	c.(340-342)TCT>TGT	p.S114C		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	114					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGGCACCAGAGATGTCTCATG	0.463													29	102					0	0	0	0	C	73414358	C	C	73414358	3	2	94	1	0	0	0	0	1	0	0	0	267	942	33	2	3356	2	ADAMTS3	4	73414358	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	17103478	73414358	117739918	74	18248											
BANK1	55024	broad.mit.edu	37	chr4	102751026	102751026	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggaatgggctctgtacttGacagaagtatttttacatgt	11	14	11	5	0	1	2	0	1	1	1	1	4	1	3	0	2	2	3	0	2	5	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:102751026G>C	uc003hvy.3	+	2	406	c.132G>C	c.(130-132)TTG>TTC	p.L44F	BANK1_uc003hvx.3_Missense_Mutation_p.L29F|BANK1_uc010ill.2_Intron|BANK1_uc003hvz.3_Missense_Mutation_p.L14F	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	44	Interaction with ITPR2.				B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		CTCTGTACTTGACAGAAGTAT	0.333													4	47					0	0	0	0	C	102751026	C	C	102751026	3	2	94	1	0	0	0	0	1	0	0	0	1311	1281	45	2	138	2	BANK1	4	102751026	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	29336668	102751026	88403250	75	18249											
TACR3	6870	broad.mit.edu	37	chr4	104640753	104640753	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggccgccccggcagctagcGaggcggtcaggttcacggcg	5	5	17	14	6	2	0	2	0	0	0	2	1	2	0	3	6	2	3	3	6	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:104640753G>A	uc003hxe.1	-	1	223	c.80C>T	c.(79-81)TCG>TTG	p.S27L		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	27	Extracellular (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGCAGCTAGCGAGGCGGTCAG	0.682													10	35					0	0	0	0	A	104640753	A	A	104640753	3	1	94	1	0	0	0	0	1	0	0	0	15573	1059	37	1	1337	1	TACR3	4	104640753	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1889727	104640753	86513523	76	18250											
PCDH10	57575	broad.mit.edu	37	chr4	134076091	134076091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttctgcattccaggaagccGacatagtaagctctaaggac	12	9	10	10	1	2	0	0	0	2	0	3	3	3	2	2	2	3	4	2	2	4	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:134076091G>A	uc003iha.2	+	3	3536	c.2710G>A	c.(2710-2712)GAC>AAC	p.D904N		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	904	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CCAGGAAGCCGACATAGTAAG	0.433													12	26					0	0	0	0	A	134076091	A	A	134076091	3	1	94	1	0	0	0	0	1	0	0	0	11561	1058	37	1	2780	1	PCDH10	4	134076091	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	29435338	134076091	57078185	77	18251											
FBXW7	55294	broad.mit.edu	37	chr4	153247366	153247366	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaaccctaagagtggcatctCgagaaccgctaacaactctg	14	7	8	12	2	2	2	0	0	2	2	3	3	2	2	2	1	4	2	2	1	5	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:153247366C>T	uc003ims.2	-	10	1585	c.1436G>A	c.(1435-1437)CGA>CAA	p.R479Q	FBXW7_uc011cii.1_Missense_Mutation_p.R479Q|FBXW7_uc003imt.2_Missense_Mutation_p.R479Q|FBXW7_uc011cih.1_Missense_Mutation_p.R303Q|FBXW7_uc003imq.2_Missense_Mutation_p.R399Q|FBXW7_uc003imr.2_Missense_Mutation_p.R361Q	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	479	WD 3.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R479Q(31)|p.R479L(7)|p.R479G(3)|p.R399Q(2)|p.R240L(1)|p.R399L(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403			Mis|N|D|F		colorectal|endometrial|T-ALL								12	38					0	0	0	0	T	153247366	T	T	153247366	3	4	94	1	0	0	0	0	1	0	0	0	5801	884	31	1	699	1	FBXW7	4	153247366	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	19171275	153247366	37906910	78	18252											
MORF4	10934	broad.mit.edu	37	chr4	174537509	174537509	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacattcttctcggcaggaaGatagaagagctgtttttgcc	10	12	10	9	1	2	3	0	0	2	3	3	4	2	4	1	2	2	3	1	2	3	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:174537509G>T	uc011cke.1	-	1	286	c.286C>A	c.(286-288)CTT>ATT	p.L96I		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TCGGCAGGAAGATAGAAGAGC	0.378													29	146					1.39806e-14	1.51613e-14	1	0	T	174537509	T	T	174537509	3	4	94	1	0	0	0	0	1	0	0	0	9758	942	33	2	424	2	MORF4	4	174537509	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	21290143	174537509	16616767	79	18253											
NEIL3	55247	broad.mit.edu	37	chr4	178272586	178272586	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggacatctagcagggtggatCatgttatggactccgtggct	8	11	14	8	1	2	0	1	0	1	0	3	3	3	3	1	5	1	3	1	5	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:178272586C>T	uc003iut.2	+	7	1039	c.922C>T	c.(922-924)CAT>TAT	p.H308Y	NEIL3_uc010irs.2_Intron	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	308					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		CAGGGTGGATCATGTTATGGA	0.398								BER_DNA_glycosylases					34	75					0	0	0	0	T	178272586	T	T	178272586	3	4	94	1	0	0	0	0	1	0	0	0	10374	826	29	2	948	2	NEIL3	4	178272586	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	3735077	178272586	12881690	80	18254											
CDKN2AIP	55602	broad.mit.edu	37	chr4	184367411	184367411	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagagagtgggaactcagctCggagctctggcatctccagt	9	8	13	11	1	3	1	1	0	2	1	5	4	3	3	1	3	3	3	1	3	1	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:184367411C>T	uc003ivp.1	+	3	736	c.574C>T	c.(574-576)CGG>TGG	p.R192W	CDKN2AIP_uc003ivq.1_5'UTR	NM_017632	NP_060102	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	192	Ser-rich.				negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding				0		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GAACTCAGCTCGGAGCTCTGG	0.512													6	44					0	0	0	0	T	184367411	T	T	184367411	3	4	94	1	0	0	0	0	1	0	0	0	3177	875	31	1	584	1	CDKN2AIP	4	184367411	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	6094825	184367411	6786865	81	18255											
FAT1	2195	broad.mit.edu	37	chr4	187531171	187531171	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaatgataaatacggccccTgaatagaaatcaaaattact	18	10	5	8	1	2	3	2	2	0	1	2	3	2	3	2	1	2	0	2	1	10	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:187531171T>A	uc003izf.2	-	15	10042	c.9854_splice	c.e15-1	p.G3285_splice		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATACGGCCCCTGAATAGAAAT	0.413										HNSCC(5;0.00058)			5	12					0	0	0	0	A	187531171	A	A	187531171	5	1	94	1	0	0	0	0	0	0	1	0	5721	1594	55	5	3966	5	FAT1	4	187531171	Splice_Site	SNP	T	TCGA-CQ-5327-01A-01D-1683-08	3163760	187531171	3623105	82	18256											
FAT1	2195	broad.mit.edu	37	chr4	187541129	187541129	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccgggctgttagcctgcAcgtggaccacagggctgtgc	5	9	14	13	2	0	0	0	0	0	0	1	1	1	1	3	3	3	4	3	3	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:187541129A>C	uc003izf.2	-	10	6799	c.6611T>G	c.(6610-6612)GTG>GGG	p.V2204G		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2204	Extracellular (Potential).|Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTTAGCCTGCACGTGGACCAC	0.483										HNSCC(5;0.00058)			29	102					0	0	0	0	C	187541129	C	C	187541129	3	2	94	1	0	0	0	0	1	0	0	0	5721	159	6	5	7227	5	FAT1	4	187541129	Missense_Mutation	SNP	A	TCGA-CQ-5327-01A-01D-1683-08	9958	187541129	3613147	83	18257											
FAT1	2195	broad.mit.edu	37	chr4	187541201	187541201	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaaaggtttttcaaacacaGgcatggctttattcatgaca	14	12	8	7	0	2	2	2	1	0	1	2	2	2	2	0	3	1	3	0	3	3	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:187541201G>A	uc003izf.2	-	10	6727	c.6539C>T	c.(6538-6540)CCT>CTT	p.P2180L		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2180	Extracellular (Potential).|Cadherin 19.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTCAAACACAGGCATGGCTTT	0.483										HNSCC(5;0.00058)			9	51					0	0	0	0	A	187541201	A	A	187541201	3	1	94	1	0	0	0	0	1	0	0	0	5721	1000	35	4	7299	4	FAT1	4	187541201	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	72	187541201	3613075	84	18258											
SLC9A3	6550	broad.mit.edu	37	chr5	482690	482690	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atgacggtgaagaacactacGatgatggtggtgctgacgaa	13	8	14	6	3	0	5	0	4	0	1	0	7	0	5	0	3	3	1	0	3	4	1	rs141238439		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:482690G>C	uc003jbe.2	-	7	1441	c.1329C>G	c.(1327-1329)ATC>ATG	p.I443M	SLC9A3_uc011clx.1_Missense_Mutation_p.I443M	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	443	Helical; Name=M/M10; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AGAACACTACGATGATGGTGG	0.662													15	66					0	0	0	0	C	482690	C	C	482690	3	2	94	1	0	0	0	0	1	0	0	0	14777	1048	37	3	1219	3	SLC9A3	5	482690	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		482690	180432570	85	18259											
GHR	2690	broad.mit.edu	37	chr5	42718786	42718786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaccagctgttgtgaacctGacattctggagactgatttc	9	13	10	9	0	1	4	0	3	1	1	2	5	1	4	2	1	3	3	2	1	2	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:42718786G>A	uc003jmt.2	+	10	1220	c.1177G>A	c.(1177-1179)GAC>AAC	p.D393N	GHR_uc011cpq.1_Missense_Mutation_p.D206N	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	393	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTGTGAACCTGACATTCTGGA	0.473													20	76					0	0	0	0	A	42718786	A	A	42718786	3	1	94	1	0	0	0	0	1	0	0	0	6408	1290	45	2	1211	2	GHR	5	42718786	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	42236096	42718786	138196474	86	18260											
C5orf39	389289	broad.mit.edu	37	chr5	43040059	43040060	+	Frame_Shift_Ins	INS	-	GAAC	GAAC																															gccacggcccacgatcttctINSgaactcacaataggtggagg																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:43040059_43040060insGAAC	uc003jnf.2	-	1	388_389	c.89_90insGTTC	c.(88-90)TCAfs	p.S30fs	C5orf39_uc010ivj.1_RNA|LOC153684_uc003jng.2_5'Flank|LOC153684_uc003jni.2_5'Flank	NM_001014279	NP_001014301	Q3ZCQ2	AX2R_HUMAN	annexin II receptor	30							receptor activity				0						CACGATCTTCTGAACTCACAAT	0.569											OREG0016598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								GAAC	43040060	GAAC	GAAC	43040059	7	5	94	1	0	1	1	0	0	0	0	0	2307	1567	55	0	495	0	C5orf39	5	43040059	Frame_Shift_Ins	INS	-	TCGA-CQ-5327-01A-01D-1683-08	321273	43040059	137875201	87	18261											
PARP8	79668	broad.mit.edu	37	chr5	50055555	50055555	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aataccagtaatttttcataGaatagcaacaggtaatagta	18	12	6	5	0	1	1	1	0	0	1	1	1	1	1	1	1	3	4	1	1	10	9			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:50055555G>A	uc003jon.3	+	5	445	c.263G>A	c.(262-264)AGA>AAA	p.R88K	PARP8_uc011cpz.1_Intron|PARP8_uc003joo.2_Missense_Mutation_p.R88K|PARP8_uc003jop.2_Missense_Mutation_p.R88K	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	88						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				ATTTTTCATAGAATAGCAACA	0.259													9	48					0	0	0	0	A	50055555	A	A	50055555	3	1	94	1	0	0	0	0	1	0	0	0	11519	942	33	2	277	2	PARP8	5	50055555	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	7015496	50055555	130859705	88	18262											
PDE4D	5144	broad.mit.edu	37	chr5	58289223	58289223	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatgtgtttgatataaactCtgacacttgatttccagacc	12	14	7	8	0	1	4	0	3	1	1	2	5	2	4	2	0	1	1	2	0	4	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:58289223C>G	uc003jsa.2	-	7	1163	c.991G>C	c.(991-993)GAG>CAG	p.E331Q	PDE4D_uc003jrx.2_Missense_Mutation_p.E195Q|PDE4D_uc003jry.2_Missense_Mutation_p.E29Q|PDE4D_uc003jrz.2_Missense_Mutation_p.E267Q|PDE4D_uc003jsb.2_Missense_Mutation_p.E270Q|PDE4D_uc003jrt.2_Missense_Mutation_p.E29Q|PDE4D_uc003jru.2_Missense_Mutation_p.E107Q|PDE4D_uc003jrv.2_Missense_Mutation_p.E201Q|PDE4D_uc003jrw.2_Missense_Mutation_p.E209Q|PDE4D_uc010iwi.1_3'UTR|PDE4D_uc003jrs.2_Missense_Mutation_p.E40Q	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	331					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GATATAAACTCTGACACTTGA	0.343													12	41					0	0	0	0	G	58289223	G	G	58289223	3	3	94	1	0	0	0	0	1	0	0	0	11696	922	32	2	1474	2	PDE4D	5	58289223	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	8233668	58289223	122626037	89	18263											
ERBB2IP	55914	broad.mit.edu	37	chr5	65339965	65339965	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tacttattttatttctctagGagggaaatttaaaaagatat	15	17	6	3	0	1	1	0	0	1	1	2	3	1	3	0	2	1	0	0	2	9	9			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:65339965G>A	uc003juk.1	+	17	1737	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K	ERBB2IP_uc003juh.1_Missense_Mutation_p.E477K|ERBB2IP_uc003jui.1_Missense_Mutation_p.E477K|ERBB2IP_uc003juj.1_Missense_Mutation_p.E477K|ERBB2IP_uc011cqx.1_Missense_Mutation_p.E477K|ERBB2IP_uc011cqy.1_Missense_Mutation_p.E477K|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.E477K|ERBB2IP_uc003jul.1_Missense_Mutation_p.E477K	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	477					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		ATTTCTCTAGGAGGGAAATTT	0.284													10	37					0	0	0	0	A	65339965	A	A	65339965	3	1	94	1	0	0	0	0	1	0	0	0	5231	1188	41	2	1487	2	ERBB2IP	5	65339965	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	7050742	65339965	115575295	90	18264											
GPR98	84059	broad.mit.edu	37	chr5	90103466	90103466	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggaaaggagttttcctgTggacgtttcctagccctggt	9	12	12	8	1	0	0	0	0	0	0	2	3	2	3	3	4	1	2	3	4	3	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:90103466T>C	uc003kju.2	+	73	14980	c.14884T>C	c.(14884-14886)TGG>CGG	p.W4962R	GPR98_uc003kjt.2_Missense_Mutation_p.W2668R|GPR98_uc003kjw.2_Missense_Mutation_p.W623R	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4962	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGTTTTCCTGTGGACGTTTCC	0.468													10	28					0	0	0	0	C	90103466	C	C	90103466	3	2	94	1	0	0	0	0	1	0	0	0	6760	1696	59	5	15174	5	GPR98	5	90103466	Missense_Mutation	SNP	T	TCGA-CQ-5327-01A-01D-1683-08	24763501	90103466	90811794	91	18265											
SHROOM1	134549	broad.mit.edu	37	chr5	132159668	132159668	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtggctctgggctgggctggGaagcaagagggtcacataga	9	7	18	7	0	2	2	1	0	1	2	2	3	2	3	0	5	1	4	0	5	3	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:132159668G>A	uc003kxx.2	-	7	2490	c.1685C>T	c.(1684-1686)TCC>TTC	p.S562F	SHROOM1_uc003kxy.1_Missense_Mutation_p.S562F	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	562	ASD2.				actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCTGGGCTGGGAAGCAAGAGG	0.632													18	32					0	0	0	0	A	132159668	A	A	132159668	3	1	94	1	0	0	0	0	1	0	0	0	14358	1174	41	2	889	2	SHROOM1	5	132159668	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	42056202	132159668	48755592	92	18266											
CTNNA1	1495	broad.mit.edu	37	chr5	138266343	138266343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagatgacagactttacccGgtgagcagcaccccggcccc	9	5	12	15	2	0	4	0	2	0	2	0	5	0	4	5	3	3	2	5	3	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:138266343G>A	uc003ldh.2	+	15	2287	c.2192G>A	c.(2191-2193)CGA>CAA	p.R731Q	CTNNA1_uc011cyx.1_Missense_Mutation_p.R628Q|CTNNA1_uc011cyy.1_Missense_Mutation_p.R608Q|CTNNA1_uc003ldi.2_Missense_Mutation_p.R429Q|CTNNA1_uc003ldj.2_Missense_Mutation_p.R731Q|CTNNA1_uc003ldl.2_Missense_Mutation_p.R361Q	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	731					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GACTTTACCCGGTGAGCAGCA	0.577													19	78					0	0	0	0	A	138266343	A	A	138266343	3	1	94	1	0	0	0	0	1	0	0	0	4029	1130	39	1	2246	1	CTNNA1	5	138266343	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	6106675	138266343	42648917	93	18267											
PCDHGA11	56105	broad.mit.edu	37	chr5	140800862	140800862	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtgcattttcctggggaCgctgcgggggttccgggcca	3	10	17	11	3	0	0	0	0	0	0	2	1	2	1	3	5	2	4	3	5	0	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:140800862C>T	uc003lkq.1	+	1	326	c.68C>T	c.(67-69)ACG>ATG	p.T23M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.T23M|PCDHGA11_uc003lkp.1_Missense_Mutation_p.T23M	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	23					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCTGGGGACGCTGCGGGGG	0.622													4	25					0	0	0	0	T	140800862	T	T	140800862	3	4	94	1	0	0	0	0	1	0	0	0	11606	536	19	1	70	1	PCDHGA11	5	140800862	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	2534519	140800862	40114398	94	18268											
ARSI	340075	broad.mit.edu	37	chr5	149677914	149677914	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctcaccctcgtgcaggtcGaagccgcacacgcctgggcc	6	7	11	17	4	1	0	1	0	1	0	4	1	1	0	4	2	2	2	4	2	1	1	rs150264448	byFrequency	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:149677914G>A	uc003lrv.2	-	2	1162	c.573C>T	c.(571-573)TTC>TTT	p.F191F		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	191						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGTGCAGGTCGAAGCCGCACA	0.627													5	23					0	0	0	0	A	149677914	A	A	149677914	2	1	94	1	0	0	0	0	0	0	0	1	996	1049	37	1		1	ARSI	5	149677914	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	8877052	149677914	31237346	95	18269											
FAT2	2196	broad.mit.edu	37	chr5	150946494	150946494	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgttttatcacatgttacagGaacttcaaaatgagggtcct	12	14	8	7	0	2	1	2	1	0	0	3	2	3	2	1	2	2	2	1	2	5	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:150946494G>T	uc003lue.3	-	1	2012	c.1999C>A	c.(1999-2001)CCT>ACT	p.P667T	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.P667T	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	667	Extracellular (Potential).|Cadherin 5.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATGTTACAGGAACTTCAAAA	0.423													22	99					3.62473e-10	3.86558e-10	1	0	T	150946494	T	T	150946494	3	4	94	1	0	0	0	0	1	0	0	0	5722	1174	41	2	11142	2	FAT2	5	150946494	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1268580	150946494	29968766	96	18270											
FAT2	2196	broad.mit.edu	37	chr5	150946976	150946976	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccccaggtaggggtcaataGaaaatggcaaagcttttggt	12	10	12	7	0	1	1	1	0	0	1	2	1	2	1	2	5	1	3	2	5	6	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:150946976G>A	uc003lue.3	-	1	1530	c.1517C>T	c.(1516-1518)TCT>TTT	p.S506F	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.S506F	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	506	Cadherin 4.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGGTCAATAGAAAATGGCAA	0.483													10	59					0	0	0	0	A	150946976	A	A	150946976	3	1	94	1	0	0	0	0	1	0	0	0	5722	942	33	2	11624	2	FAT2	5	150946976	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	482	150946976	29968284	97	18271											
C1QTNF2	114898	broad.mit.edu	37	chr5	159776351	159776351	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggccacatcgtggttgcCggtgttggcatcaaaggtcc	7	10	14	10	2	1	1	1	1	0	0	3	1	2	1	3	5	1	3	3	5	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:159776351C>T	uc003lyd.2	-	3	821	c.817G>A	c.(817-819)GGC>AGC	p.G273S		NM_031908	NP_114114	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	228	C1q.					collagen				skin(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCGTGGTTGCCGGTGTTGGCA	0.577													4	91					0	0	0	0	T	159776351	T	T	159776351	3	4	94	1	0	0	0	0	1	0	0	0	1972	652	23	1	179	1	C1QTNF2	5	159776351	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	8829375	159776351	21138909	98	18272											
WWC1	23286	broad.mit.edu	37	chr5	167812240	167812240	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactcagattgaggatcctcGagtacaatggcggcgggagc	10	7	14	10	3	1	2	1	1	0	1	3	5	2	4	1	4	2	1	1	4	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:167812240G>A	uc003lzu.2	+	3	347	c.254G>A	c.(253-255)CGA>CAA	p.R85Q	WWC1_uc003lzv.2_Missense_Mutation_p.R85Q|WWC1_uc011den.1_Missense_Mutation_p.R85Q	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	85	WW 2.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GAGGATCCTCGAGTACAATGG	0.527													5	23					0	0	0	0	A	167812240	A	A	167812240	3	1	94	1	0	0	0	0	1	0	0	0	17479	1058	37	1	264	1	WWC1	5	167812240	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	8035889	167812240	13103020	99	18273											
DOCK2	1794	broad.mit.edu	37	chr5	169503008	169503008	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagggtgtcagataacttgCgacccttccatgaccggatg	11	9	11	10	2	1	2	1	1	0	1	2	4	2	3	3	2	2	0	3	2	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:169503008C>T	uc003maf.2	+	47	4866	c.4786C>T	c.(4786-4788)CGA>TGA	p.R1596*	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Nonsense_Mutation_p.R1088*|DOCK2_uc003mah.2_Nonsense_Mutation_p.R152*	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1596	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATAACTTGCGACCCTTCCA	0.502													34	86					0	0	0	0	T	169503008	T	T	169503008	4	4	94	1	0	0	0	0	0	1	0	0	4709	760	27	1	4972	1	DOCK2	5	169503008	Nonsense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	1690768	169503008	11412252	100	18274											
CNOT6	57472	broad.mit.edu	37	chr5	179998330	179998330	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acaaacttcagctgtcatggGaagaatggaaccaccaatgg	15	7	10	9	0	2	1	2	0	0	1	2	3	2	3	2	3	3	1	2	3	5	1	rs34154769		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:179998330G>A	uc003mlx.2	+	11	1708	c.1359G>A	c.(1357-1359)GGG>GGA	p.G453G	CNOT6_uc010jld.2_Silent_p.G453G|CNOT6_uc010jle.2_Silent_p.G448G	NM_015455	NP_056270	Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	453					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding				0	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)		GCTGTCATGGGAAGAATGGAA	0.403													26	51					0	0	0	0	A	179998330	A	A	179998330	2	1	94	1	0	0	0	0	0	0	0	1	3637	1161	41	2		2	CNOT6	5	179998330	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	10495322	179998330	916930	101	18275											
BTN3A3	10384	broad.mit.edu	37	chr6	26452578	26452578	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccaccctggagctgaggtctCcccttctgcaacaaccaatc	9	8	7	17	0	2	1	0	1	2	0	4	2	2	2	5	2	4	2	5	2	3	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:26452578C>T	uc003nhz.2	+	11	1874	c.1694C>T	c.(1693-1695)TCC>TTC	p.S565F	BTN3A3_uc003nia.2_Missense_Mutation_p.S523F|BTN3A3_uc011dkn.1_Missense_Mutation_p.S516F	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	565	Cytoplasmic (Potential).					integral to membrane					0						GCTGAGGTCTCCCCTTCTGCA	0.383													9	19					0	0	0	0	T	26452578	T	T	26452578	3	4	94	1	0	0	0	0	1	0	0	0	1569	855	30	2	1728	2	BTN3A3	6	26452578	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08		26452578	144662489	102	18276											
PPP1R11	6992	broad.mit.edu	37	chr6	30037047	30037047	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acccctccccagcctcctgaCccttcccagccccctccagg	5	6	5	25	0	0	1	0	1	0	0	4	1	4	1	11	1	2	0	11	1	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:30037047C>G	uc003npb.2	+	3	601	c.345C>G	c.(343-345)GAC>GAG	p.D115E	PPP1R11_uc010jrw.2_RNA|PPP1R11_uc003npc.2_RNA	NM_021959	NP_068778	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor)	115	Pro-rich.					soluble fraction	protein binding|protein phosphatase inhibitor activity			ovary(1)|lung(1)|skin(1)	3						AGCCTCCTGACCCTTCCCAGC	0.597													19	88					0	0	0	0	G	30037047	G	G	30037047	3	3	94	1	0	0	0	0	1	0	0	0	12413	506	18	4	355	4	PPP1R11	6	30037047	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	3584469	30037047	141078020	103	18277											
ITPR3	3710	broad.mit.edu	37	chr6	33636878	33636878	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaagagtgtgaggcagctgGcccaggaggcgcgggccggc	8	3	20	10	3	0	3	0	1	0	2	0	4	0	4	2	6	1	2	2	6	1	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:33636878G>A	uc011drk.1	+	18	2353	c.2134G>A	c.(2134-2136)GCC>ACC	p.A712T		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	712	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GAGGCAGCTGGCCCAGGAGGC	0.602													7	82					0	0	0	0	A	33636878	A	A	33636878	3	1	94	1	0	0	0	0	1	0	0	0	7961	1203	42	4	2204	4	ITPR3	6	33636878	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	3599831	33636878	137478189	104	18278											
TTBK1	84630	broad.mit.edu	37	chr6	43230734	43230734	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgacagcaaagagtgggtCatcatcgacaaggagacgga	14	6	13	8	3	2	2	2	0	0	2	4	6	2	3	0	3	1	1	0	3	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:43230734C>A	uc003ouq.1	+	13	1911	c.1632C>A	c.(1630-1632)GTC>GTA	p.V544V	TTBK1_uc011dvg.1_Silent_p.V67V	NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	544						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			AAGAGTGGGTCATCATCGACA	0.642													10	10					1.58986e-06	1.66237e-06	1	0	A	43230734	A	A	43230734	2	1	94	1	0	0	0	0	0	0	0	1	16744	813	29	2		2	TTBK1	6	43230734	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	9593856	43230734	127884333	105	18279											
ABCC10	89845	broad.mit.edu	37	chr6	43400148	43400148	+	Frame_Shift_Del	DEL	G	-	-																															ccctggtagccttgctgccaGctccagccctagtgctgacc																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:43400148delG	uc003ouy.1	+	3	645	c.430delG	c.(430-432)GCTfs	p.A144fs	ABCC10_uc003ouz.1_Frame_Shift_Del_p.A101fs	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	144	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CTTGCTGCCAGCTCCAGCCCT	0.652													---	---	---								-	43400148	-	-	43400148	7	5	94	1	0	1	0	1	0	0	0	0	50	971	34	0	303	0	ABCC10	6	43400148	Frame_Shift_Del	DEL	G	TCGA-CQ-5327-01A-01D-1683-08	169414	43400148	127714919	106	18280											
LRRC1	55227	broad.mit.edu	37	chr6	53761313	53761313	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagtctttataacctggcttCactggaactgagagagaatc	12	12	9	8	0	2	2	1	1	1	2	3	5	2	3	1	2	2	1	1	2	5	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:53761313C>T	uc003pcd.1	+	5	741	c.464C>T	c.(463-465)TCA>TTA	p.S155L		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	155	LRR 7.					cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		AACCTGGCTTCACTGGAACTG	0.368													14	51					0	0	0	0	T	53761313	T	T	53761313	3	4	94	1	0	0	0	0	1	0	0	0	9016	838	29	2	482	2	LRRC1	6	53761313	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	10361165	53761313	117353754	107	18281											
HTR1E	3354	broad.mit.edu	37	chr6	87725456	87725456	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaatacgccaggaagaggaCggccaagagggccgcgctga	12	3	16	10	4	0	4	0	2	0	2	0	6	0	6	3	4	1	1	3	4	4	1	rs143974435		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:87725456C>T	uc003pli.2	+	2	1107	c.404C>T	c.(403-405)ACG>ATG	p.T135M		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	135	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	AGGAAGAGGACGGCCAAGAGG	0.577													19	44					0	0	0	0	T	87725456	T	T	87725456	3	4	94	1	0	0	0	0	1	0	0	0	7478	536	19	1	406	1	HTR1E	6	87725456	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	33964143	87725456	83389611	108	18282											
REV3L	5980	broad.mit.edu	37	chr6	111678329	111678329	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggagtctgatatctgatatCtaaaaaacaaacaaaatgtc	18	11	6	6	0	3	2	0	2	3	0	4	3	3	3	0	1	2	0	0	1	8	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:111678329C>G	uc003puy.3	-	18	7396	c.7073_splice	c.e18-1	p.D2358_splice	REV3L_uc003pux.3_Splice_Site_p.D2280_splice|REV3L_uc003puz.3_Splice_Site_p.D2280_splice|REV3L_uc003pva.1_Splice_Site	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta						DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TATCTGATATCTAAAAAACAA	0.264								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					10	35					0	0	0	0	G	111678329	G	G	111678329	5	3	94	1	0	0	0	0	0	0	1	0	13305	927	32	2	2380	2	REV3L	6	111678329	Splice_Site	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	23952873	111678329	59436738	109	18283											
KPNA5	3841	broad.mit.edu	37	chr6	117047696	117047696	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttttcctgttttgattgaGattcttcagaaagcagagtt	10	18	8	5	0	2	4	1	2	1	3	3	5	3	4	1	0	1	3	1	0	1	8			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:117047696G>C	uc003pxh.2	+	12	1295	c.1164G>C	c.(1162-1164)GAG>GAC	p.E388D		NM_002269	NP_002260	O15131	IMA5_HUMAN	karyopherin alpha 5	385	NLS binding site (minor) (By similarity).|ARM 8.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		TTTTGATTGAGATTCTTCAGA	0.338													22	67					0	0	0	0	C	117047696	C	C	117047696	3	2	94	1	0	0	0	0	1	0	0	0	8472	933	33	2	1210	2	KPNA5	6	117047696	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	5369367	117047696	54067371	110	18284											
AGPAT4	56895	broad.mit.edu	37	chr6	161575246	161575246	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaccgtcttgcgatcctgctCccacttgcgcgaacagaaga	10	8	9	14	4	1	2	0	0	1	2	3	4	3	2	3	0	5	1	3	0	3	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:161575246C>G	uc003qtr.1	-	4	672	c.445G>C	c.(445-447)GAG>CAG	p.E149Q	AGPAT4_uc003qts.1_Missense_Mutation_p.E9Q|AGPAT4_uc011egb.1_Intron|AGPAT4_uc003qtt.1_RNA|AGPAT4_uc011egc.1_Missense_Mutation_p.E149Q|AGPAT4_uc011egd.1_Missense_Mutation_p.E87Q|AGPAT4_uc011ege.1_Missense_Mutation_p.G92A	NM_020133	NP_064518	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	149					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding				0		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		CGATCCTGCTCCCACTTGCGC	0.562													11	62					0	0	0	0	G	161575246	G	G	161575246	3	3	94	1	0	0	0	0	1	0	0	0	389	864	30	2	715	2	AGPAT4	6	161575246	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	44527550	161575246	9539821	111	18285											
T	6862	broad.mit.edu	37	chr6	166580264	166580264	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagcggtggttgtccgccGccacgaagtccagcaggaag	8	6	14	13	4	0	0	0	0	0	0	3	2	3	1	5	3	2	2	5	3	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:166580264G>A	uc003quu.1	-	3	780	c.287C>T	c.(286-288)GCG>GTG	p.A96V	T_uc003qut.1_Missense_Mutation_p.A96V|T_uc003quv.1_Missense_Mutation_p.A96V	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	96	T-box.				anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		GTTGTCCGCCGCCACGAAGTC	0.657									Chordoma_Familial_Clustering_of				5	51					0	0	0	0	A	166580264	A	A	166580264	3	1	94	1	0	0	0	0	1	0	0	0	15554	1087	38	1	1048	1	T	6	166580264	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	5005018	166580264	4534803	112	18286											
DLL1	28514	broad.mit.edu	37	chr6	170592567	170592569	+	In_Frame_Del	DEL	CTT	-	-																															atgatgctgactgagatgtcCttctcacgctggcagttggc																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:170592567_170592569delCTT	uc003qxm.2	-	9	2268_2270	c.1798_1800delAAG	c.(1798-1800)AAGdel	p.K600del		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	600	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CTGAGATGTCCTTCTCACGCTGG	0.631													---	---	---								-	170592569	-	-	170592567	7	5	94	1	0	1	0	1	0	0	0	0	4588	680	24	0	383	0	DLL1	6	170592567	In_Frame_Del	DEL	CTT	TCGA-CQ-5327-01A-01D-1683-08	4012303	170592567	522500	113	18287											
COX19	90639	broad.mit.edu	37	chr7	1012890	1012890	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaaaattattgttatgaaGacacttcatgaatttctctt	13	18	4	6	0	3	3	2	2	1	1	4	3	3	3	0	0	0	1	0	0	6	7			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:1012890G>A	uc003sjp.1	-	2	211	c.121C>T	c.(121-123)CTT>TTT	p.L41F	ADAP1_uc010ksc.2_5'UTR	NM_001031617	NP_001026788	Q49B96	COX19_HUMAN	COX19 cytochrome c oxidase assembly homolog	41	CHCH.					cytosol					0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;2.15e-15)		TTGTTATGAAGACACTTCATG	0.343													9	56					0	0	0	0	A	1012890	A	A	1012890	3	1	94	1	0	0	0	0	1	0	0	0	3783	942	33	2	159	2	COX19	7	1012890	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		1012890	158125773	114	18288											
DNAH11	8701	broad.mit.edu	37	chr7	21750198	21750198	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactcttattttataggtctCttctcatccattctacgaga	9	18	4	10	1	4	1	1	0	4	1	7	2	5	1	1	1	2	0	1	1	5	8			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:21750198C>G	uc003svc.2	+	42	6763	c.6732C>G	c.(6730-6732)CTC>CTG	p.L2244L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2244	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TTATAGGTCTCTTCTCATCCA	0.348									Kartagener_syndrome				4	19					0	0	0	0	G	21750198	G	G	21750198	2	3	94	1	0	0	0	0	0	0	0	1	4621	900	32	2		2	DNAH11	7	21750198	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	20737308	21750198	137388465	115	18289											
RAPGEF5	9771	broad.mit.edu	37	chr7	22259497	22259499	+	In_Frame_Del	DEL	CTC	-	-																															aggcttacgtgttcagacttCtcctgttcttttttgtccgt																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:22259497_22259499delCTC	uc003svg.2	-	9	836_838	c.523_525delGAG	c.(523-525)GAGdel	p.E175del		NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	Error:Variant_position_missing_in_Q92565_after_alignment					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						GTTCAGACTTCTCCTGTTCTTTT	0.419													---	---	---								-	22259499	-	-	22259497	7	5	94	1	0	1	0	1	0	0	0	0	13112	912	32	0	1739	0	RAPGEF5	7	22259497	In_Frame_Del	DEL	CTC	TCGA-CQ-5327-01A-01D-1683-08	509299	22259497	136879166	116	18290											
FAM188B	84182	broad.mit.edu	37	chr7	30830790	30830790	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actccctttaggattcttttCacagacactatctgagacgg	10	13	7	11	1	3	2	1	1	2	2	4	4	4	3	1	2	0	0	1	2	2	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:30830790C>T	uc003tbt.2	+	5	750	c.673C>T	c.(673-675)CAC>TAC	p.H225Y	FAM188B_uc010kwe.2_Missense_Mutation_p.H196Y	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	225											0						GGATTCTTTTCACAGACACTA	0.438													48	149					0	0	0	0	T	30830790	T	T	30830790	3	4	94	1	0	0	0	0	1	0	0	0	5543	826	29	2	691	2	FAM188B	7	30830790	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	8571293	30830790	128307873	117	18291											
PDE1C	5137	broad.mit.edu	37	chr7	31918650	31918650	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcactgcgtgaacgatgctCttgaaccggggcttctcgtc	6	11	12	12	4	2	2	0	2	2	0	4	3	2	2	1	2	5	3	1	2	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:31918650C>G	uc003tcm.1	-	4	853	c.384G>C	c.(382-384)AAG>AAC	p.K128N	PDE1C_uc003tcn.1_Missense_Mutation_p.K128N|PDE1C_uc003tco.1_Missense_Mutation_p.K188N|PDE1C_uc003tcr.2_Missense_Mutation_p.K128N|PDE1C_uc003tcs.2_Missense_Mutation_p.K128N	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	128					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			GAACGATGCTCTTGAACCGGG	0.532													21	62					0	0	0	0	G	31918650	G	G	31918650	3	3	94	1	0	0	0	0	1	0	0	0	11689	912	32	2	1576	2	PDE1C	7	31918650	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	1087860	31918650	127220013	118	18292											
ABCA13	154664	broad.mit.edu	37	chr7	48237849	48237849	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctaggttatttgcagccccGagatctacccagctgtggtg	7	12	11	11	1	2	1	0	0	2	1	2	2	2	1	3	2	4	3	3	2	3	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:48237849G>A	uc003toq.2	+	3	204	c.179G>A	c.(178-180)CGA>CAA	p.R60Q	ABCA13_uc003top.2_Missense_Mutation_p.R60Q|ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	60					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTGCAGCCCCGAGATCTACCC	0.408													6	18					0	0	0	0	A	48237849	A	A	48237849	3	1	94	1	0	0	0	0	1	0	0	0	31	1058	37	1	18	1	ABCA13	7	48237849	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	16319199	48237849	110900814	119	18293											
ABCA13	154664	broad.mit.edu	37	chr7	48284261	48284261	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttcagcttgatggagctCtcagaaatgcgatagctcag	10	12	10	9	1	4	2	3	1	2	1	5	4	4	3	0	1	4	3	0	1	2	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:48284261C>G	uc003toq.2	+	11	1376	c.1351C>G	c.(1351-1353)CTC>GTC	p.L451V	ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	451					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TGATGGAGCTCTCAGAAATGC	0.428													11	53					0	0	0	0	G	48284261	G	G	48284261	3	3	94	1	0	0	0	0	1	0	0	0	31	913	32	2	1222	2	ABCA13	7	48284261	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	46412	48284261	110854402	120	18294											
PEX1	5189	broad.mit.edu	37	chr7	92146808	92146808	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tttactttgctgttgctttgGagaaagtagcttaactagct	9	17	9	6	0	0	1	0	0	0	1	0	2	0	1	0	1	6	6	0	1	5	8	rs137856931		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:92146808G>C	uc003uly.2	-	5	1117	c.1021C>G	c.(1021-1023)CCA>GCA	p.P341A	PEX1_uc011khr.1_Missense_Mutation_p.P133A|PEX1_uc010ley.2_Missense_Mutation_p.P341A|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	341					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TGTTGCTTTGGAGAAAGTAGC	0.368													13	39					0	0	0	0	C	92146808	C	C	92146808	3	2	94	1	0	0	0	0	1	0	0	0	11790	1174	41	2	2910	2	PEX1	7	92146808	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	43862547	92146808	66991855	121	18295											
ZAN	7455	broad.mit.edu	37	chr7	100345237	100345237	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactggcaggctgtttctgtCaattacacagccgtgggacg	9	10	12	10	2	2	0	1	0	1	0	2	1	2	1	1	3	3	3	1	3	3	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:100345237C>G	uc003uwj.2	+	9	1161	c.996C>G	c.(994-996)GTC>GTG	p.V332V	ZAN_uc003uwk.2_Silent_p.V332V|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	332	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTGTTTCTGTCAATTACACAG	0.488													14	45					0	0	0	0	G	100345237	G	G	100345237	2	3	94	1	0	0	0	0	0	0	0	1	17581	813	29	2		2	ZAN	7	100345237	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	8198429	100345237	58793426	122	18296											
ZAN	7455	broad.mit.edu	37	chr7	100346010	100346010	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgtgactgggtccagacttCcggggatggtggacactggg	6	9	17	9	1	0	2	0	1	0	1	2	4	2	4	2	6	0	0	2	6	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:100346010C>T	uc003uwj.2	+	11	1331	c.1166C>T	c.(1165-1167)TCC>TTC	p.S389F	ZAN_uc003uwk.2_Missense_Mutation_p.S389F|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	389	MAM 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GTCCAGACTTCCGGGGATGGT	0.537													12	47					0	0	0	0	T	100346010	T	T	100346010	3	4	94	1	0	0	0	0	1	0	0	0	17581	855	30	2	1204	2	ZAN	7	100346010	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	773	100346010	58792653	123	18297											
RELN	5649	broad.mit.edu	37	chr7	103151303	103151303	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcataacatttcaccttgaAttgcataatccagccttcag	13	13	4	11	0	3	1	3	1	0	0	4	1	4	1	3	0	3	1	3	0	3	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:103151303A>G	uc003vca.2	-	51	8429	c.8269T>C	c.(8269-8271)TTC>CTC	p.F2757L	RELN_uc010liz.2_Missense_Mutation_p.F2757L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2757					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCACCTTGAATTGCATAATC	0.388													8	28					0	0	0	0	G	103151303	G	G	103151303	3	3	94	1	0	0	0	0	1	0	0	0	13285	101	4	5	2173	5	RELN	7	103151303	Missense_Mutation	SNP	A	TCGA-CQ-5327-01A-01D-1683-08	2805293	103151303	55987360	124	18298											
RINT1	60561	broad.mit.edu	37	chr7	105183014	105183014	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcaaccttggatggacgatCttggaaccatgattagccag	11	9	11	10	2	1	1	0	1	1	0	1	5	1	4	3	3	3	1	3	3	3	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:105183014C>G	uc003vda.1	+	4	664	c.433C>G	c.(433-435)CTT>GTT	p.L145V	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	145					cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						GATGGACGATCTTGGAACCAT	0.413													19	34					0	0	0	0	G	105183014	G	G	105183014	3	3	94	1	0	0	0	0	1	0	0	0	13441	913	32	2	447	2	RINT1	7	105183014	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	2031711	105183014	53955649	125	18299											
NRCAM	4897	broad.mit.edu	37	chr7	107875082	107875082	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacaatattctcccgagggtCaataatgtaatcttttggag	12	14	8	7	1	3	0	1	0	2	0	4	2	3	1	1	2	1	1	1	2	6	7			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:107875082C>T	uc003vfb.2	-	6	646	c.175G>A	c.(175-177)GAC>AAC	p.D59N	NRCAM_uc003vfc.2_Missense_Mutation_p.D53N|NRCAM_uc011kmk.1_Missense_Mutation_p.D54N|NRCAM_uc003vfd.2_Missense_Mutation_p.D54N|NRCAM_uc003vfe.2_Missense_Mutation_p.D54N	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	59	Ig-like 1.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TCCCGAGGGTCAATAATGTAA	0.358													20	55					0	0	0	0	T	107875082	T	T	107875082	3	4	94	1	0	0	0	0	1	0	0	0	10698	826	29	2	3881	2	NRCAM	7	107875082	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	2692068	107875082	51263581	126	18300											
CFTR	1080	broad.mit.edu	37	chr7	117227829	117227829	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagaaagacaatatagttCttggagaaggtggaatcaca	17	8	11	5	0	2	3	1	0	1	3	2	6	2	4	0	3	0	1	0	3	6	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:117227829C>A	uc003vjd.2	+	12	1753	c.1621C>A	c.(1621-1623)CTT>ATT	p.L541I	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	541	Cytoplasmic (Potential).|ABC transporter 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CAATATAGTTCTTGGAGAAGG	0.358									Cystic_Fibrosis				18	29					5.35356e-11	5.72831e-11	1	0	A	117227829	A	A	117227829	3	1	94	1	0	0	0	0	1	0	0	0	3309	913	32	2	1667	2	CFTR	7	117227829	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	9352747	117227829	41910834	127	18301											
NUP205	23165	broad.mit.edu	37	chr7	135292096	135292096	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcggtgcgagaatctcctCagctggctgagctatgttac	7	11	13	10	2	2	2	1	1	1	1	3	3	2	2	1	3	4	4	1	3	3	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:135292096C>T	uc003vsw.2	+	22	3203	c.3172C>T	c.(3172-3174)CAG>TAG	p.Q1058*		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1058					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						AGAATCTCCTCAGCTGGCTGA	0.498													21	38					0	0	0	0	T	135292096	T	T	135292096	4	4	94	1	0	0	0	0	0	1	0	0	10813	827	29	2	3258	2	NUP205	7	135292096	Nonsense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	18064267	135292096	23846567	128	18302											
TMUB1	83590	broad.mit.edu	37	chr7	150779330	150779330	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgaatcattgaggaatttCagccgtagcacgaggggctc	10	10	12	9	2	3	2	2	2	1	0	4	4	3	3	1	3	2	3	1	3	3	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:150779330C>T	uc003wjb.2	-	1	436	c.321G>A	c.(319-321)CTG>CTA	p.L107L	FASTK_uc003wiw.1_5'Flank|FASTK_uc003wix.1_5'Flank|FASTK_uc003wiy.1_5'Flank|FASTK_uc003wiz.1_5'Flank|FASTK_uc003wja.1_5'Flank|TMUB1_uc003wjc.2_Silent_p.L107L|TMUB1_uc003wjd.2_Silent_p.L107L	NM_031434	NP_113622	Q9BVT8	TMUB1_HUMAN	transmembrane and ubiquitin-like domain	107	Ubiquitin-like.					cytoplasm|integral to membrane|nucleus					0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGAGGAATTTCAGCCGTAGCA	0.597													68	200					0	0	0	0	T	150779330	T	T	150779330	2	4	94	1	0	0	0	0	0	0	0	1	16330	813	29	2		2	TMUB1	7	150779330	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	15487234	150779330	8359333	129	18303											
MTMR9	66036	broad.mit.edu	37	chr8	11152790	11152790	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctggaatggaggaatgcttGaatatagccagttccattga	12	11	11	7	0	0	2	0	2	0	0	1	5	1	5	3	3	2	2	3	3	5	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:11152790G>A	uc003wtm.2	+	2	668	c.270G>A	c.(268-270)TTG>TTA	p.L90L	MTMR9_uc010lrx.2_5'UTR|MTMR9_uc011kxa.1_Silent_p.L5L	NM_015458	NP_056273	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	90						cytoplasm	phosphatase activity|protein binding				0			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		AGGAATGCTTGAATATAGCCA	0.323													16	115					0	0	0	0	A	11152790	A	A	11152790	2	1	94	1	0	0	0	0	0	0	0	1	10003	1281	45	2		2	MTMR9	8	11152790	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		11152790	135211232	130	18304											
ADAMDEC1	27299	broad.mit.edu	37	chr8	24256527	24256527	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttctaacctggggaaaaaGatccacgaccatgctcagct	13	8	9	11	1	2	1	1	0	1	1	3	3	3	2	3	2	3	3	3	2	3	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:24256527G>T	uc003xdz.2	+	9	1123	c.903G>T	c.(901-903)AAG>AAT	p.K301N	ADAMDEC1_uc010lub.2_Missense_Mutation_p.K222N|ADAMDEC1_uc011lab.1_Missense_Mutation_p.K222N	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	301	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		TGGGGAAAAAGATCCACGACC	0.512													7	25					3.09899e-07	3.26155e-07	1	0	T	24256527	T	T	24256527	3	4	94	1	0	0	0	0	1	0	0	0	254	933	33	2	937	2	ADAMDEC1	8	24256527	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	13103737	24256527	122107495	131	18305											
MOS	4342	broad.mit.edu	37	chr8	57025568	57025568	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcgctcggcctctgcgccGcgctgggtctccagcagcgc	2	6	15	18	7	2	0	0	0	2	0	4	0	2	0	3	2	3	3	3	2	0	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:57025568G>A	uc011leb.1	-	1	974	c.974C>T	c.(973-975)GCG>GTG	p.A325V		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	325	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			CCTCTGCGCCGCGCTGGGTCT	0.627													8	32					0	0	0	0	A	57025568	A	A	57025568	3	1	94	1	0	0	0	0	1	0	0	0	9765	1087	38	1	69	1	MOS	8	57025568	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	32769041	57025568	89338454	132	18306											
C8orf45	157777	broad.mit.edu	37	chr8	67808488	67808488	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacagatgacttttccagttCagtgcagtttttggtctttt	8	18	8	7	0	2	2	1	1	1	1	3	2	3	2	1	1	2	3	1	1	1	7			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:67808488C>T	uc003xwz.3	+	11	1534	c.1363C>T	c.(1363-1365)CAG>TAG	p.Q455*	C8orf45_uc011lev.1_Nonsense_Mutation_p.Q455*|C8orf45_uc011lew.1_Nonsense_Mutation_p.Q386*|C8orf45_uc011lex.1_Nonsense_Mutation_p.Q213*|C8orf45_uc003xwy.3_Nonsense_Mutation_p.Q455*	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	455					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TTTTCCAGTTCAGTGCAGTTT	0.388													14	69					0	0	0	0	T	67808488	T	T	67808488	4	4	94	1	0	0	0	0	0	1	0	0	2442	827	29	2	1401	2	C8orf45	8	67808488	Nonsense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	10782920	67808488	78555534	133	18307											
CCNE2	9134	broad.mit.edu	37	chr8	95902690	95902690	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcatctgtggttccaagtCagaatgcagaacttcaaaat	13	11	7	10	0	4	2	3	0	1	2	5	2	5	2	2	1	2	2	2	1	5	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:95902690C>T	uc003yhc.2	-	6	515	c.406G>A	c.(406-408)GAC>AAC	p.D136N	CCNE2_uc003yhd.2_Missense_Mutation_p.D136N	NM_057749	NP_477097	O96020	CCNE2_HUMAN	cyclin E2	136					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding				0	Breast(36;8.75e-07)					GGTTCCAAGTCAGAATGCAGA	0.373													45	190					0	0	0	0	T	95902690	T	T	95902690	3	4	94	1	0	0	0	0	1	0	0	0	2936	826	29	2	836	2	CCNE2	8	95902690	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	28094202	95902690	50461332	134	18308											
COL14A1	7373	broad.mit.edu	37	chr8	121381598	121381598	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggagagtcggcctggcagcCctgggccccctggctctcct	3	7	15	16	1	1	1	0	0	1	1	3	2	1	1	5	5	1	2	5	5	0	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:121381598C>T	uc003yox.2	+	47	5450	c.5185C>T	c.(5185-5187)CCT>TCT	p.P1729S	COL14A1_uc003yoz.2_Missense_Mutation_p.P694S	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1729	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GCCTGGCAGCCCTGGGCCCCC	0.582													18	56					0	0	0	0	T	121381598	T	T	121381598	3	4	94	1	0	0	0	0	1	0	0	0	3686	623	22	4	5367	4	COL14A1	8	121381598	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	25478908	121381598	24982424	135	18309											
PLEC	5339	broad.mit.edu	37	chr8	144997457	144997457	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcggcctccgtggcctccgCcttcagccgctgcagctcct	2	9	11	19	4	1	0	1	0	0	0	4	0	4	0	7	2	4	3	7	2	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:144997457C>T	uc003zaf.1	-	31	7221	c.7051G>A	c.(7051-7053)GCG>ACG	p.A2351T	PLEC_uc003zab.1_Missense_Mutation_p.A2214T|PLEC_uc003zac.1_Missense_Mutation_p.A2218T|PLEC_uc003zad.2_Missense_Mutation_p.A2214T|PLEC_uc003zae.1_Missense_Mutation_p.A2182T|PLEC_uc003zag.1_Missense_Mutation_p.A2192T|PLEC_uc003zah.2_Missense_Mutation_p.A2200T|PLEC_uc003zaj.2_Missense_Mutation_p.A2241T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2351	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTGGCCTCCGCCTTCAGCCGC	0.662													5	11					0	0	0	0	T	144997457	T	T	144997457	3	4	94	1	0	0	0	0	1	0	0	0	12107	739	26	4	7011	4	PLEC	8	144997457	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	23615859	144997457	1366565	136	18310											
KIF24	347240	broad.mit.edu	37	chr9	34286638	34286638	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	taagaggagctccacactgtCcacctgaagctcttgcagtc	10	9	9	13	0	1	2	0	1	1	1	4	3	3	3	3	1	3	3	3	1	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:34286638C>G	uc003zua.3	-	6	1312	c.1192G>C	c.(1192-1194)GAC>CAC	p.D398H	KIF24_uc010mkb.2_Missense_Mutation_p.D429H	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	398	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			TCCACACTGTCCACCTGAAGC	0.443													9	55					0	0	0	0	G	34286638	G	G	34286638	3	3	94	1	0	0	0	0	1	0	0	0	8331	855	30	2	2946	2	KIF24	9	34286638	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08		34286638	106926793	137	18311											
KIAA1045	23349	broad.mit.edu	37	chr9	34976157	34976157	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttattttcaggacaacatCaacttgctgcttactgagga	11	13	7	10	0	2	1	2	1	0	0	2	3	2	3	1	2	5	2	1	2	4	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:34976157C>T	uc003zvq.2	+	4	751	c.573C>T	c.(571-573)ATC>ATT	p.I191I	KIAA1045_uc003zvr.2_Silent_p.I191I	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	191							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			AGGACAACATCAACTTGCTGC	0.458													14	36					0	0	0	0	T	34976157	T	T	34976157	2	4	94	1	0	0	0	0	0	0	0	1	8246	816	29	2		2	KIAA1045	9	34976157	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	689519	34976157	106237274	138	18312											
ANKRD20A4	728747	broad.mit.edu	37	chr9	69420272	69420272	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttattaaaggtcaaagaaGgaaataatacaaacaaaagt	22	10	6	3	0	1	1	1	0	0	1	1	2	1	2	0	2	2	0	0	2	11	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:69420272G>A	uc004afn.2	+	13	1274	c.1162G>A	c.(1162-1164)GGA>AGA	p.G388R		NM_001098805	NP_001092275	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	388											0						GGTCAAAGAAGGAAATAATAC	0.259													3	45					0	0	0	0	A	69420272	A	A	69420272	3	1	94	1	0	0	0	0	1	0	0	0	650	1001	35	4	1212	4	ANKRD20A4	9	69420272	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	34444115	69420272	71793159	139	18313											
TRPM3	80036	broad.mit.edu	37	chr9	73225627	73225627	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaacttcctcttcatccttCttcctggaggactccccgtt	5	15	6	15	1	3	1	1	1	2	0	7	3	7	3	5	2	1	1	5	2	1	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:73225627C>G	uc004aid.2	-	18	2773	c.2529G>C	c.(2527-2529)AAG>AAC	p.K843N	TRPM3_uc004ahu.2_Missense_Mutation_p.K673N|TRPM3_uc004ahv.2_Missense_Mutation_p.K645N|TRPM3_uc004ahw.2_Missense_Mutation_p.K715N|TRPM3_uc004ahx.2_Missense_Mutation_p.K702N|TRPM3_uc004ahy.2_Missense_Mutation_p.K705N|TRPM3_uc004ahz.2_Missense_Mutation_p.K692N|TRPM3_uc004aia.2_Missense_Mutation_p.K690N|TRPM3_uc004aib.2_Missense_Mutation_p.K680N|TRPM3_uc004aic.2_Missense_Mutation_p.K843N	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	868	Extracellular (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CTTCATCCTTCTTCCTGGAGG	0.388													12	94					0	0	0	0	G	73225627	G	G	73225627	3	3	94	1	0	0	0	0	1	0	0	0	16654	912	32	2	2626	2	TRPM3	9	73225627	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	3805355	73225627	67987804	140	18314											
GOLM1	51280	broad.mit.edu	37	chr9	88650317	88650317	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgctcctcctcctgtccGtcggggatgacaagctggtc	4	11	11	15	2	0	1	0	1	0	0	7	2	5	2	5	3	2	2	5	3	1	0	rs147755244		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:88650317G>A	uc004aol.2	-	8	1179	c.981C>T	c.(979-981)GAC>GAT	p.D327D	GOLM1_uc004aom.2_Silent_p.D327D	NM_016548	NP_057632	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1	327	Lumenal (Potential).					Golgi apparatus|integral to plasma membrane					0						CCTCCTGTCCGTCGGGGATGA	0.637											OREG0019278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	66					0	0	0	0	A	88650317	A	A	88650317	2	1	94	1	0	0	0	0	0	0	0	1	6604	1136	40	1		1	GOLM1	9	88650317	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	15424690	88650317	52563114	141	18315											
GSN	2934	broad.mit.edu	37	chr9	124091231	124091231	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccccacggctgaaggacAagaagatggatgcccatcct	12	6	10	13	1	0	3	0	1	0	2	2	5	2	5	4	3	1	1	4	3	3	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:124091231A>G	uc004blf.1	+	14	2039	c.1978A>G	c.(1978-1980)AAG>GAG	p.K660E	GSN_uc004bld.1_Missense_Mutation_p.K609E|GSN_uc010mvq.1_Missense_Mutation_p.K620E|GSN_uc010mvr.1_Missense_Mutation_p.K620E|GSN_uc010mvu.1_Missense_Mutation_p.K609E|GSN_uc010mvt.1_Missense_Mutation_p.K609E|GSN_uc010mvs.1_Missense_Mutation_p.K609E|GSN_uc004ble.1_Missense_Mutation_p.K609E|GSN_uc010mvv.1_Missense_Mutation_p.K609E|GSN_uc011lyh.1_Missense_Mutation_p.K626E|GSN_uc011lyi.1_Missense_Mutation_p.K609E|GSN_uc011lyj.1_Missense_Mutation_p.K633E|GSN_uc004blg.1_Missense_Mutation_p.K391E	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	660	Actin-binding, Ca-sensitive (Potential).				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						GCTGAAGGACAAGAAGATGGA	0.622													6	25					0	0	0	0	G	124091231	G	G	124091231	3	3	94	1	0	0	0	0	1	0	0	0	6864	131	5	5	2060	5	GSN	9	124091231	Missense_Mutation	SNP	A	TCGA-CQ-5327-01A-01D-1683-08	35440914	124091231	17122200	142	18316											
BAT2L1	84726	broad.mit.edu	37	chr9	134351594	134351594	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtgggccgcaggtcccctGagctctcctaccagaactcc	6	8	10	17	1	1	2	0	1	1	1	4	2	3	2	6	2	3	2	6	2	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:134351594G>C	uc004can.3	+	15	4133	c.4078G>C	c.(4078-4080)GAG>CAG	p.E1360Q	BAT2L1_uc010mzj.1_Missense_Mutation_p.E943Q|BAT2L1_uc004cao.3_Missense_Mutation_p.E718Q	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1360							protein binding				0						CAGGTCCCCTGAGCTCTCCTA	0.672											OREG0019561	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	19					0	0	0	0	C	134351594	C	C	134351594	3	2	94	1	0	0	0	0	1	0	0	0	1322	1291	45	2	4136	2	BAT2L1	9	134351594	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	10260363	134351594	6861837	143	18317											
ZMYND11	10771	broad.mit.edu	37	chr10	267290	267290	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtccctggcagtgcccagtTtgcagggtgagtacctatga	8	10	13	10	0	0	2	0	2	0	0	1	2	1	2	3	2	3	4	3	2	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:267290T>C	uc010pzt.1	+	4	860	c.432T>C	c.(430-432)GTT>GTC	p.V144V	ZMYND11_uc001ifk.2_Silent_p.V144V|ZMYND11_uc010pzu.1_Silent_p.V144V|ZMYND11_uc010pzv.1_Intron|ZMYND11_uc010pzw.1_Intron|ZMYND11_uc001ifm.2_Intron|ZMYND11_uc010pzx.1_Silent_p.V144V|ZMYND11_uc001ifn.2_Intron|ZMYND11_uc009xhg.2_Silent_p.V127V|ZMYND11_uc009xhh.2_Intron|ZMYND11_uc010pzy.1_Intron	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	104	PHD-type.				cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		AGTGCCCAGTTTGCAGGGTGA	0.453													14	78					0	0	0	0	C	267290	C	C	267290	2	2	94	1	0	0	0	0	0	0	0	1	17773	1828	64	5		5	ZMYND11	10	267290	Silent	SNP	T	TCGA-CQ-5327-01A-01D-1683-08		267290	135267457	144	18318											
C10orf18	54906	broad.mit.edu	37	chr10	5781788	5781788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacttcttccacaccagtatCtgaggctagaaatcttcact	11	13	5	12	0	4	2	1	1	3	1	5	2	5	2	2	1	1	2	2	1	4	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:5781788C>T	uc001iij.2	+	13	2280	c.1655C>T	c.(1654-1656)TCT>TTT	p.S552F	C10orf18_uc001iik.2_Intron	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	552										ovary(1)|central_nervous_system(1)	2						ACACCAGTATCTGAGGCTAGA	0.403													29	78					0	0	0	0	T	5781788	T	T	5781788	3	4	94	1	0	0	0	0	1	0	0	0	1602	913	32	2	1693	2	C10orf18	10	5781788	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	5514498	5781788	129752959	145	18319											
PHYH	5264	broad.mit.edu	37	chr10	13323083	13323083	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacgtcaatgtagtggcaatCggcactggcgaaatggcagg	11	7	14	9	3	1	0	1	0	0	0	2	1	1	0	0	5	0	4	0	5	4	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:13323083C>T	uc001imf.2	-	8	944	c.856G>A	c.(856-858)GAT>AAT	p.D286N	PHYH_uc001ime.2_Missense_Mutation_p.D186N|PHYH_uc001img.2_Missense_Mutation_p.D269N	NM_006214	NP_006205	O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase isoform a precursor	286					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding				0		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	TAGTGGCAATCGGCACTGGCG	0.433													15	58					0	0	0	0	T	13323083	T	T	13323083	3	4	94	1	0	0	0	0	1	0	0	0	11919	884	31	1	168	1	PHYH	10	13323083	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	7541295	13323083	122211664	146	18320											
FZD8	8325	broad.mit.edu	37	chr10	35928655	35928655	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgcaggtcccgcaggcacGggcagttgtgcgtggcctcc	4	7	16	14	3	0	0	0	0	0	0	2	0	2	0	3	4	2	6	3	4	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:35928655G>A	uc001iyz.1	-	1	1708	c.1703C>T	c.(1702-1704)CCG>CTG	p.P568L		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	568	Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						CCGCAGGCACGGGCAGTTGTG	0.672													12	35					0	0	0	0	A	35928655	A	A	35928655	3	1	94	1	0	0	0	0	1	0	0	0	6170	1116	39	1	385	1	FZD8	10	35928655	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	22605572	35928655	99606092	147	18321											
BTAF1	9044	broad.mit.edu	37	chr10	93719794	93719794	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgtggttttaaaacacatGaacgaaacaggagttcataa	16	10	10	5	1	1	1	1	1	0	0	1	3	1	2	0	3	3	2	0	3	5	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:93719794G>C	uc001khr.2	+	11	1244	c.1146G>C	c.(1144-1146)ATG>ATC	p.M382I	BTAF1_uc001khs.1_Missense_Mutation_p.M52I	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	382					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TAAAACACATGAACGAAACAG	0.383													29	87					0	0	0	0	C	93719794	C	C	93719794	3	2	94	1	0	0	0	0	1	0	0	0	1541	1290	45	2	1188	2	BTAF1	10	93719794	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	57791139	93719794	41814953	148	18322											
PLCE1	51196	broad.mit.edu	37	chr10	95791053	95791053	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagaaaatagtgagtgatGagaacagtaatgaaaaatgt	19	8	13	1	0	0	5	0	4	0	2	0	7	0	5	0	1	1	1	0	1	7	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:95791053G>C	uc001kjk.2	+	2	884	c.250G>C	c.(250-252)GAG>CAG	p.E84Q	PLCE1_uc010qnx.1_Missense_Mutation_p.E84Q	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	84					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				AGTGAGTGATGAGAACAGTAA	0.383													25	58					0	0	0	0	C	95791053	C	C	95791053	3	2	94	1	0	0	0	0	1	0	0	0	12089	1291	45	2	252	2	PLCE1	10	95791053	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	2071259	95791053	39743694	149	18323											
LOC729020	729020	broad.mit.edu	37	chr10	105005975	105005975	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatgcacatgatggtgtcCaagccagaacagtgggtaaa	14	7	12	8	0	0	2	0	1	0	1	1	3	1	2	2	2	3	2	2	2	4	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:105005975C>A	uc009xxi.2	+	1	332	c.222C>A	c.(220-222)TCC>TCA	p.S74S	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	74					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						TGATGGTGTCCAAGCCAGAAC	0.488													8	113					7.93312e-07	8.322e-07	1	0	A	105005975	A	A	105005975	2	1	94	1	0	0	0	0	0	0	0	1	8938	581	21	4		4	LOC729020	10	105005975	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	9214922	105005975	30528772	150	18324											
COL17A1	1308	broad.mit.edu	37	chr10	105796297	105796297	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagctctgcatagtccaaaGacaggagggacccatctcca	12	7	9	13	0	3	1	1	0	2	1	5	3	4	3	3	2	2	2	3	2	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:105796297G>C	uc001kxr.2	-	48	3540	c.3371C>G	c.(3370-3372)TCT>TGT	p.S1124C		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1124	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		ATAGTCCAAAGACAGGAGGGA	0.592													7	25					0	0	0	0	C	105796297	C	C	105796297	3	2	94	1	0	0	0	0	1	0	0	0	3689	942	33	2	1158	2	COL17A1	10	105796297	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	790322	105796297	29738450	151	18325											
EMX2	2018	broad.mit.edu	37	chr10	119303110	119303110	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccacaccccctattcgcctCgcagcagcgggatccgtcca	7	6	9	19	4	0	0	0	0	0	0	4	1	2	1	6	1	2	2	6	1	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:119303110C>T	uc001ldh.3	+	1	1155	c.332C>T	c.(331-333)TCG>TTG	p.S111L	EMX2OS_uc001ldf.2_5'Flank|EMX2OS_uc001ldg.2_Intron|EMX2_uc001ldi.3_Missense_Mutation_p.S111L	NM_004098	NP_004089	Q04743	EMX2_HUMAN	empty spiracles homeobox 2 isoform 1	111						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		CTATTCGCCTCGCAGCAGCGG	0.697													17	46					0	0	0	0	T	119303110	T	T	119303110	3	4	94	1	0	0	0	0	1	0	0	0	5132	893	31	1	334	1	EMX2	10	119303110	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	13506813	119303110	16231637	152	18326											
C10orf120	399814	broad.mit.edu	37	chr10	124457552	124457553	+	Frame_Shift_Ins	INS	-	T	T																															ttatttctcgtctttttgtgINSttttttccctctgcctcctc																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:124457552_124457553insT	uc001lgn.2	-	3	736_737	c.704_705insA	c.(703-705)AACfs	p.N235fs		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	235										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				GTCTTTTTGTGTTTTTTCCCTC	0.371													---	---	---								T	124457553	T	T	124457552	7	5	94	1	0	1	1	0	0	0	0	0	1596	1368	48	0	306	0	C10orf120	10	124457552	Frame_Shift_Ins	INS	-	TCGA-CQ-5327-01A-01D-1683-08	5154442	124457552	11077195	153	18327											
NLRP6	171389	broad.mit.edu	37	chr11	280967	280967	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcgggacctgtcgcgcacGtccaagaccaccacgtcagt	8	6	12	15	5	1	1	1	0	0	1	4	2	2	2	4	2	0	1	4	2	1	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:280967G>A	uc010qvs.1	+	4	1233	c.1233G>A	c.(1231-1233)ACG>ACA	p.T411T	NLRP6_uc010qvt.1_Silent_p.T411T	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	411	NACHT.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		TGTCGCGCACGTCCAAGACCA	0.652													43	134					0	0	0	0	A	280967	A	A	280967	2	1	94	1	0	0	0	0	0	0	0	1	10535	1132	40	1		1	NLRP6	11	280967	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		280967	134725549	154	18328											
OR51M1	390059	broad.mit.edu	37	chr11	5411115	5411115	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcctaattgtcatcttcCggggacctgtggccactatc	7	11	10	13	1	2	0	1	0	1	0	4	1	3	1	4	4	0	0	4	4	2	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:5411115C>T	uc010qzc.1	+	1	487	c.487C>T	c.(487-489)CGG>TGG	p.R163W	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	163						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTCATCTTCCGGGGACCTGT	0.542													42	180					0	0	0	0	T	5411115	T	T	5411115	3	4	94	1	0	0	0	0	1	0	0	0	11157	643	23	1	489	1	OR51M1	11	5411115	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	5130148	5411115	129595401	155	18329											
ST5	6764	broad.mit.edu	37	chr11	8751512	8751512	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attacctgctctgggacttgCggtgaccacgcatgtccttc	6	12	10	13	2	1	1	0	1	1	0	3	2	2	2	3	2	3	2	3	2	1	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:8751512C>T	uc001mgt.2	-	3	1511	c.1325G>A	c.(1324-1326)CGC>CAC	p.R442H	ST5_uc009yfr.2_Intron|ST5_uc001mgu.2_Intron|ST5_uc001mgv.2_Missense_Mutation_p.R442H|ST5_uc010rbq.1_Intron|ST5_uc001mgw.1_Missense_Mutation_p.R442H	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	442	Interaction with ABL1.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CTGGGACTTGCGGTGACCACG	0.577													6	409					0	0	0	0	T	8751512	T	T	8751512	3	4	94	1	0	0	0	0	1	0	0	0	15286	768	27	1	2160	1	ST5	11	8751512	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	3340397	8751512	126255004	156	18330											
USP47	55031	broad.mit.edu	37	chr11	11964241	11964241	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgaaaacatcgaatcaccTctcaatgagagggactcttc	13	11	7	10	1	3	2	2	2	2	1	6	5	3	3	1	1	1	0	1	1	4	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:11964241T>C	uc001mjq.1	+	21	3496	c.2733T>C	c.(2731-2733)CCT>CCC	p.P911P	USP47_uc001mjr.2_Silent_p.P823P|USP47_uc001mjs.2_Silent_p.P891P|USP47_uc001mjt.1_Silent_p.P197P	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	911				P -> S (in Ref. 1; BAG54467).	base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TCGAATCACCTCTCAATGAGA	0.413													4	57					0	0	0	0	C	11964241	C	C	11964241	2	2	94	1	0	0	0	0	0	0	0	1	17146	1538	54	5		5	USP47	11	11964241	Silent	SNP	T	TCGA-CQ-5327-01A-01D-1683-08	3212729	11964241	123042275	157	18331											
SPTY2D1	144108	broad.mit.edu	37	chr11	18633881	18633881	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttttcggtcataaccaaaGatttctctaatgtgcttgga	10	17	7	7	1	2	1	1	0	1	1	4	2	2	2	1	2	2	1	1	2	3	7			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:18633881G>A	uc001moy.2	-	4	2082	c.1866C>T	c.(1864-1866)ATC>ATT	p.I622I	SPTY2D1_uc010rdi.1_Silent_p.I622I	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	622										breast(1)	1						CATAACCAAAGATTTCTCTAA	0.323													16	64					0	0	0	0	A	18633881	A	A	18633881	2	1	94	1	0	0	0	0	0	0	0	1	15192	932	33	2		2	SPTY2D1	11	18633881	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	6669640	18633881	116372635	158	18332											
ZNF408	79797	broad.mit.edu	37	chr11	46726882	46726882	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaactgcggcgccatctcatCtcacacaccggggaggccca	9	5	11	16	3	2	0	2	0	2	0	4	2	2	1	3	4	2	0	3	4	1	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:46726882C>G	uc001nde.1	+	5	1862	c.1632C>G	c.(1630-1632)ATC>ATG	p.I544M	ZNF408_uc010rgw.1_Missense_Mutation_p.I536M	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	544	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						GCCATCTCATCTCACACACCG	0.677													10	24					0	0	0	0	G	46726882	G	G	46726882	3	3	94	1	0	0	0	0	1	0	0	0	17955	903	32	2	1682	2	ZNF408	11	46726882	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	28093001	46726882	88279634	159	18333											
OR4C11	219429	broad.mit.edu	37	chr11	55371308	55371308	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgcaggcaagtttcaacaagGgctgcaaatcacagcaataa	16	7	9	9	0	2	0	2	0	0	0	2	0	2	0	0	2	4	6	0	2	6	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:55371308G>A	uc010rii.1	-	1	542	c.542C>T	c.(541-543)CCC>CTC	p.P181L		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTTCAACAAGGGCTGCAAATC	0.403													16	14					0	0	0	0	A	55371308	A	A	55371308	3	1	94	1	0	0	0	0	1	0	0	0	11099	1232	43	4	392	4	OR4C11	11	55371308	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	8644426	55371308	79635208	160	18334											
OR5R1	219479	broad.mit.edu	37	chr11	56185150	56185150	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtgtgtctgagcaggacaGagctaagaaggggaggtcat	11	8	17	5	0	2	3	1	1	1	2	2	5	2	5	0	4	2	2	0	4	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:56185150G>C	uc010rji.1	-	1	559	c.559C>G	c.(559-561)CTG>GTG	p.L187V		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAGCAGGACAGAGCTAAGAAG	0.448													15	54					0	0	0	0	C	56185150	C	C	56185150	3	2	94	1	0	0	0	0	1	0	0	0	11234	933	33	2	417	2	OR5R1	11	56185150	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	813842	56185150	78821366	161	18335											
AHNAK	79026	broad.mit.edu	37	chr11	62289230	62289230	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caatgtccaccttgggtcctGagacgtcaaggtcagccttg	8	10	11	12	1	2	1	2	1	0	1	4	2	4	1	4	2	1	0	4	2	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:62289230G>C	uc001ntl.2	-	5	12959	c.12659C>G	c.(12658-12660)TCA>TGA	p.S4220*	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4220					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTTGGGTCCTGAGACGTCAAG	0.483													72	245					0	0	0	0	C	62289230	C	C	62289230	4	2	94	1	0	0	0	0	0	1	0	0	414	1294	45	2	5133	2	AHNAK	11	62289230	Nonsense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	6104080	62289230	72717286	162	18336											
FERMT3	83706	broad.mit.edu	37	chr11	63990638	63990638	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcaacatgcgccagtggAatgtcaactgggacatccgg	11	7	12	11	2	2	0	2	0	0	0	3	2	3	2	2	3	4	1	2	3	3	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:63990638A>T	uc001nyl.2	+	14	1950	c.1801A>T	c.(1801-1803)AAT>TAT	p.N601Y	FERMT3_uc001nym.2_Missense_Mutation_p.N597Y	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	601					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						GCGCCAGTGGAATGTCAACTG	0.637													24	70					0	0	0	0	T	63990638	T	T	63990638	3	4	94	1	0	0	0	0	1	0	0	0	5851	246	9	5	1851	5	FERMT3	11	63990638	Missense_Mutation	SNP	A	TCGA-CQ-5327-01A-01D-1683-08	1701408	63990638	71015878	163	18337											
PYGM	5837	broad.mit.edu	37	chr11	64521495	64521495	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctcactgtcacatcccaCgcctggcacacggggtgggc	6	7	12	16	2	2	0	2	0	0	0	4	0	4	0	3	4	0	1	3	4	0	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:64521495C>T	uc001oax.3	-	10	1912	c.1095G>A	c.(1093-1095)GCG>GCA	p.A365A	PYGM_uc001oay.3_Silent_p.A277A	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	365					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	TCACATCCCACGCCTGGCACA	0.672													4	11					0	0	0	0	T	64521495	T	T	64521495	2	4	94	1	0	0	0	0	0	0	0	1	12927	523	19	1		1	PYGM	11	64521495	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	530857	64521495	70485021	164	18338											
C11orf80	79703	broad.mit.edu	37	chr11	66568153	66568154	+	Frame_Shift_Del	DEL	CA	-	-																															aaggtaaatggaatcctctcCacagagatctttgggtaagt																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:66568153_66568154delCA	uc001ojf.2	+	7	766_767	c.759_760delCA	c.(757-762)TCCACAfs	p.S253fs	C11orf80_uc001ojg.2_Frame_Shift_Del_p.S19fs|C11orf80_uc001ojh.2_Frame_Shift_Del_p.S19fs|C11orf80_uc001oji.2_Frame_Shift_Del_p.S19fs|C11orf80_uc010rpk.1_Frame_Shift_Del_p.S87fs	NM_024650	NP_078926	Q8N6T0	CK080_HUMAN	hypothetical protein LOC79703	98_99											0						GAATCCTCTCCACAGAGATCTT	0.356													---	---	---								-	66568154	-	-	66568153	7	5	94	1	0	1	0	1	0	0	0	0	1670	581	21	0	785	0	C11orf80	11	66568153	Frame_Shift_Del	DEL	CA	TCGA-CQ-5327-01A-01D-1683-08	2046658	66568153	68438363	165	18339											
PC	5091	broad.mit.edu	37	chr11	66617476	66617476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgcaggaactccaccaCggagcggggaaaggacagct	11	3	14	13	2	0	0	0	0	0	0	1	4	1	4	3	5	4	2	3	5	2	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:66617476C>T	uc001ojn.1	-	18	2879	c.2830G>A	c.(2830-2832)GTG>ATG	p.V944M	PC_uc001ojo.1_Missense_Mutation_p.V944M|PC_uc001ojp.1_Missense_Mutation_p.V944M|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	944					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	AACTCCACCACGGAGCGGGGA	0.627													9	70					0	0	0	0	T	66617476	T	T	66617476	3	4	94	1	0	0	0	0	1	0	0	0	11551	536	19	1	722	1	PC	11	66617476	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	49323	66617476	68389040	166	18340											
SHANK2	22941	broad.mit.edu	37	chr11	70331881	70331881	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtggagatagtgctggtcGtctcgaggtggtggtcgctg	4	11	19	7	4	1	1	0	0	1	1	4	3	1	1	0	6	1	2	0	6	1	1	rs146717159		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:70331881G>A	uc001oqc.2	-	21	4595	c.4517C>T	c.(4516-4518)ACG>ATG	p.T1506M	SHANK2_uc010rqn.1_Missense_Mutation_p.T918M|SHANK2_uc001opz.2_Missense_Mutation_p.T911M|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1127					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			AGTGCTGGTCGTCTCGAGGTG	0.587													27	51					0	0	0	0	A	70331881	A	A	70331881	3	1	94	1	0	0	0	0	1	0	0	0	14330	1145	40	1	1040	1	SHANK2	11	70331881	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	3714405	70331881	64674635	167	18341											
OR2AT4	341152	broad.mit.edu	37	chr11	74799942	74799942	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccatgatatggaagtcaaGgggcaggtcagccctgtagg	10	7	15	9	0	2	1	2	1	0	0	2	2	2	2	2	5	1	2	2	5	4	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:74799942G>A	uc010rro.1	-	1	817	c.817C>T	c.(817-819)CTT>TTT	p.L273F		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	273	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGGAAGTCAAGGGGCAGGTCA	0.522													19	62					0	0	0	0	A	74799942	A	A	74799942	3	1	94	1	0	0	0	0	1	0	0	0	11041	1000	35	4	148	4	OR2AT4	11	74799942	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	4468061	74799942	60206574	168	18342											
DGAT2	84649	broad.mit.edu	37	chr11	75508295	75508295	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgtggtcgggggtgcggctGagtctctgagctccatgcct	3	11	16	11	3	1	2	0	2	1	0	5	2	2	2	2	4	3	2	2	4	0	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:75508295G>C	uc001oxa.2	+	6	986	c.727G>C	c.(727-729)GAG>CAG	p.E243Q	DGAT2_uc001oxb.2_Missense_Mutation_p.E200Q	NM_032564	NP_115953	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	243	Cytoplasmic (Potential).				glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity				0	Ovarian(111;0.103)					GGGTGCGGCTGAGTCTCTGAG	0.572													24	68					0	0	0	0	C	75508295	C	C	75508295	3	2	94	1	0	0	0	0	1	0	0	0	4480	1291	45	2	749	2	DGAT2	11	75508295	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	708353	75508295	59498221	169	18343											
PICALM	8301	broad.mit.edu	37	chr11	85779727	85779727	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttgggccccatgatctcGtgggtcgtggccttgcatac	4	13	12	12	2	2	1	0	1	2	0	4	1	2	1	3	3	2	1	3	3	1	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:85779727G>A	uc001pbm.2	-	1	382	c.96C>T	c.(94-96)CAC>CAT	p.H32H	PICALM_uc001pbl.2_Silent_p.H32H|PICALM_uc001pbn.2_Silent_p.H32H|PICALM_uc010rtl.1_Intron	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly	32	ENTH.				clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				CCATGATCTCGTGGGTCGTGG	0.468			T	MLLT10|MLL	TALL|AML|								3	22					0	0	0	0	A	85779727	A	A	85779727	2	1	94	1	0	0	0	0	0	0	0	1	11935	1136	40	1		1	PICALM	11	85779727	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	10271432	85779727	49226789	170	18344											
TMEM135	65084	broad.mit.edu	37	chr11	86868385	86868385	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttttttaatttacaggcCacagaaacactattcagaat	14	16	4	7	0	1	2	1	0	0	2	1	2	1	2	1	1	2	0	1	1	5	9			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:86868385C>T	uc001pch.2	+	5	422	c.399C>T	c.(397-399)GCC>GCT	p.A133A	TMEM135_uc010rtt.1_5'UTR|TMEM135_uc001pci.2_Intron|TMEM135_uc001pcg.1_Intron	NM_022918	NP_075069	Q86UB9	TM135_HUMAN	transmembrane protein 135	133						integral to membrane					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ATTTACAGGCCACAGAAACAC	0.303													15	57					0	0	0	0	T	86868385	T	T	86868385	2	4	94	1	0	0	0	0	0	0	0	1	16117	581	21	4		4	TMEM135	11	86868385	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	1088658	86868385	48138131	171	18345											
UBTFL1	642623	broad.mit.edu	37	chr11	89819202	89819202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagaataatcgcccatctGatgacaacagcacgtttagc	13	9	9	10	2	1	3	0	2	1	1	2	4	1	3	1	1	3	2	1	1	4	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:89819202G>A	uc010rub.1	+	1	85	c.85G>A	c.(85-87)GAT>AAT	p.D29N		NM_001143975	NP_001137447	P0CB47	UBFL1_HUMAN	upstream binding transcription factor, RNA	29					multicellular organismal development	cytoplasm|nucleus	DNA binding				0						TCGCCCATCTGATGACAACAG	0.428													31	101					0	0	0	0	A	89819202	A	A	89819202	3	1	94	1	0	0	0	0	1	0	0	0	16978	1290	45	2	87	2	UBTFL1	11	89819202	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	2950817	89819202	45187314	172	18346											
TAGLN	6876	broad.mit.edu	37	chr11	117075058	117075058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgacaggctacggacgacctCggcagatcatcagttagagc	11	7	12	11	3	2	3	2	1	0	2	3	5	2	4	1	3	2	3	1	3	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:117075058C>T	uc001pqm.2	+	5	710	c.589C>T	c.(589-591)CGG>TGG	p.R197W	uc001pqk.1_5'Flank|TAGLN_uc001pql.1_Intron|TAGLN_uc001pqn.2_Missense_Mutation_p.R197W|TAGLN_uc001pqo.2_Missense_Mutation_p.R197W|TAGLN_uc001pqp.2_Missense_Mutation_p.R197W|uc001pqq.1_5'Flank	NM_003186	NP_003177	Q01995	TAGL_HUMAN	transgelin	197	Calponin-like.				muscle organ development	cytoplasm	actin binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|Epithelial(105;5.49e-05)|all cancers(92;0.000435)		CGGACGACCTCGGCAGATCAT	0.647													16	49					0	0	0	0	T	117075058	T	T	117075058	3	4	94	1	0	0	0	0	1	0	0	0	15604	875	31	1	603	1	TAGLN	11	117075058	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	27255856	117075058	17931458	173	18347											
IL10RA	3587	broad.mit.edu	37	chr11	117869847	117869847	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgacttagttcaaaactctGagggccgggctggggacaca	10	9	13	9	1	2	2	1	2	1	0	2	3	2	3	1	4	1	2	1	4	3	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:117869847G>A	uc001prv.2	+	7	1305	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	IL10RA_uc010rxl.1_Missense_Mutation_p.E390K|IL10RA_uc010rxm.1_Missense_Mutation_p.E390K|IL10RA_uc010rxn.1_Missense_Mutation_p.E261K|IL10RA_uc001prw.2_Missense_Mutation_p.E261K	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	410	Cytoplasmic (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		TCAAAACTCTGAGGGCCGGGC	0.652													10	41					0	0	0	0	A	117869847	A	A	117869847	3	1	94	1	0	0	0	0	1	0	0	0	7659	1291	45	2	1254	2	IL10RA	11	117869847	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	794789	117869847	17136669	174	18348											
MCAM	4162	broad.mit.edu	37	chr11	119181849	119181849	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggactggcagtggaagtgctGaggccagtggttgtgttgga	7	10	19	5	0	0	1	0	1	0	0	0	4	0	4	1	6	1	4	1	6	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:119181849G>A	uc001pwf.2	-	13	1625	c.1596C>T	c.(1594-1596)CTC>CTT	p.L532L	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	532	Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		TGGAAGTGCTGAGGCCAGTGG	0.577													26	145					0	0	0	0	A	119181849	A	A	119181849	2	1	94	1	0	0	0	0	0	0	0	1	9421	1277	45	2		2	MCAM	11	119181849	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1312002	119181849	15824667	175	18349											
TECTA	7007	broad.mit.edu	37	chr11	120979983	120979983	+	Frame_Shift_Del	DEL	C	-	-																															agttcacgccagaatcctttCccctgacagatgggagagcc																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:120979983delC	uc010rzo.1	+	3	262	c.262delC	c.(262-264)CCCfs	p.P88fs		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	88					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGAATCCTTTCCCCTGACAGA	0.488													---	---	---								-	120979983	-	-	120979983	7	5	94	1	0	1	0	1	0	0	0	0	15813	855	30	0	272	0	TECTA	11	120979983	Frame_Shift_Del	DEL	C	TCGA-CQ-5327-01A-01D-1683-08	1798134	120979983	14026533	176	18350											
CDON	50937	broad.mit.edu	37	chr11	125891182	125891182	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggccactcacaatggcacCgatgctattgttggcaaggc	10	8	12	11	1	1	0	1	0	0	0	1	1	1	0	2	4	1	4	2	4	3	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:125891182C>T	uc009zbw.2	-	3	438	c.310G>A	c.(310-312)GGT>AGT	p.G104S	CDON_uc001qdc.3_Missense_Mutation_p.G104S|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.G104S	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	104	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		ACAATGGCACCGATGCTATTG	0.433													5	31					0	0	0	0	T	125891182	T	T	125891182	3	4	94	1	0	0	0	0	1	0	0	0	3185	652	23	1	3556	1	CDON	11	125891182	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	4911199	125891182	9115334	177	18351											
PRDM10	56980	broad.mit.edu	37	chr11	129772280	129772280	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgatgatgtactgtgtggtCtgctgttggctgttggtctg	3	17	16	5	0	2	2	0	2	2	0	2	2	2	2	0	3	2	5	0	3	1	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:129772280C>T	uc001qfm.2	-	22	3643	c.3411G>A	c.(3409-3411)CAG>CAA	p.Q1137Q	PRDM10_uc001qfj.2_Silent_p.Q1038Q|PRDM10_uc001qfk.2_Silent_p.Q1000Q|PRDM10_uc001qfl.2_Silent_p.Q1051Q|PRDM10_uc010sbx.1_Silent_p.Q1047Q|PRDM10_uc001qfn.2_Silent_p.Q1133Q	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	1124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		ACTGTGTGGTCTGCTGTTGGC	0.547													37	100					0	0	0	0	T	129772280	T	T	129772280	2	4	94	1	0	0	0	0	0	0	0	1	12513	912	32	2		2	PRDM10	11	129772280	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	3881098	129772280	5234236	178	18352											
APLP2	334	broad.mit.edu	37	chr11	129999970	129999970	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccttacggcgttatgtccGtgctgagaacaaagatcgct	9	10	12	10	4	0	2	0	1	0	2	2	3	1	2	2	2	3	3	2	2	4	2	rs140505383	byFrequency	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:129999970G>A	uc010sby.1	+	11	1650	c.1493G>A	c.(1492-1494)CGT>CAT	p.R498H	APLP2_uc001qfp.2_Missense_Mutation_p.R498H|APLP2_uc001qfq.2_Missense_Mutation_p.R442H|APLP2_uc010sbz.1_Missense_Mutation_p.R286H|APLP2_uc001qfr.2_Missense_Mutation_p.R264H|APLP2_uc001qfs.2_Missense_Mutation_p.R269H|APLP2_uc001qfv.2_Missense_Mutation_p.R389H	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	498	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		CGTTATGTCCGTGCTGAGAAC	0.468													4	124					0	0	0	0	A	129999970	A	A	129999970	3	1	94	1	0	0	0	0	1	0	0	0	779	1145	40	1	1535	1	APLP2	11	129999970	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	227690	129999970	5006546	179	18353											
CD163	9332	broad.mit.edu	37	chr12	7639395	7639395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctcctccatttaccaggcGaagttgaccactctctgcaa	10	10	6	15	1	1	1	0	1	1	0	4	2	3	1	5	1	2	2	5	1	3	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:7639395G>A	uc001qsz.3	-	10	2286	c.2158C>T	c.(2158-2160)CGC>TGC	p.R720C	CD163_uc001qta.3_Missense_Mutation_p.R720C|CD163_uc009zfw.2_Missense_Mutation_p.R753C	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	720	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TTTACCAGGCGAAGTTGACCA	0.448													20	67					0	0	0	0	A	7639395	A	A	7639395	3	1	94	1	0	0	0	0	1	0	0	0	2982	1058	37	1	1340	1	CD163	12	7639395	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		7639395	126212500	180	18354											
LDHB	3945	broad.mit.edu	37	chr12	21794926	21794926	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccaaaatccatccatggcaGctgctgggatgaatgccaag	12	7	10	12	0	0	1	0	1	0	0	2	2	2	2	4	2	3	3	4	2	4	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:21794926G>A	uc001rfc.2	-	4	573	c.555C>T	c.(553-555)AGC>AGT	p.S185S	LDHB_uc001rfd.2_Silent_p.S185S|LDHB_uc001rfe.2_Silent_p.S185S	NM_002300	NP_002291	P07195	LDHB_HUMAN	L-lactate dehydrogenase B	185					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity			breast(2)|ovary(1)	3					NADH(DB00157)	ATCCATGGCAGCTGCTGGGAT	0.408													13	56					0	0	0	0	A	21794926	A	A	21794926	2	1	94	1	0	0	0	0	0	0	0	1	8741	962	34	4		4	LDHB	12	21794926	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	14155531	21794926	112056969	181	18355											
ABCD2	225	broad.mit.edu	37	chr12	40013386	40013386	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcgatctggtccatttcactCgatcagctgctgcatttagc	7	14	8	12	2	3	0	2	0	1	0	6	2	4	0	1	1	4	3	1	1	1	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:40013386C>G	uc001rmb.2	-	1	458	c.32G>C	c.(31-33)CGA>CCA	p.R11P		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	11	Interaction with PEX19.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						CCATTTCACTCGATCAGCTGC	0.473													4	39					0	0	0	0	G	40013386	G	G	40013386	3	3	94	1	0	0	0	0	1	0	0	0	61	884	31	3	2230	3	ABCD2	12	40013386	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	18218460	40013386	93838509	182	18356											
CNTN1	1272	broad.mit.edu	37	chr12	41374736	41374736	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaggccctccaggtggtctGagaatagaagacattagagc	12	7	12	10	0	1	4	0	1	1	4	2	5	2	4	3	3	1	0	3	3	4	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:41374736G>C	uc001rmm.1	+	16	1943	c.1830G>C	c.(1828-1830)CTG>CTC	p.L610L	CNTN1_uc001rmn.1_Silent_p.L599L	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	610	Fibronectin type-III 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CAGGTGGTCTGAGAATAGAAG	0.413													30	130					0	0	0	0	C	41374736	C	C	41374736	2	2	94	1	0	0	0	0	0	0	0	1	3655	1277	45	2		2	CNTN1	12	41374736	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1361350	41374736	92477159	183	18357											
RACGAP1	29127	broad.mit.edu	37	chr12	50392997	50392997	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacactgtctgtctcagttCttggctccagctgcctgctg	4	13	9	15	0	3	0	1	0	3	0	5	0	4	0	3	1	3	4	3	1	0	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:50392997C>G	uc001rvt.2	-	11	1116	c.806G>C	c.(805-807)AGA>ACA	p.R269T	RACGAP1_uc009zlm.1_Missense_Mutation_p.R269T|RACGAP1_uc001rvs.2_Missense_Mutation_p.R269T|RACGAP1_uc001rvu.2_Missense_Mutation_p.R269T	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	269	Interaction with SLC26A8.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						TGTCTCAGTTCTTGGCTCCAG	0.443													10	36					0	0	0	0	G	50392997	G	G	50392997	3	3	94	1	0	0	0	0	1	0	0	0	13042	913	32	2	1128	2	RACGAP1	12	50392997	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	9018261	50392997	83458898	184	18358											
KRT2	3849	broad.mit.edu	37	chr12	53040579	53040579	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcgatctccacatctagggCcagcttcacgttcatcagct	8	10	9	14	2	5	0	3	0	2	0	6	1	5	0	2	2	2	3	2	2	1	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:53040579C>G	uc001sat.2	-	7	1447	c.1414G>C	c.(1414-1416)GCC>CCC	p.A472P		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	472	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		ACATCTAGGGCCAGCTTCACG	0.622													21	68					0	0	0	0	G	53040579	G	G	53040579	3	3	94	1	0	0	0	0	1	0	0	0	8496	739	26	4	517	4	KRT2	12	53040579	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	2647582	53040579	80811316	185	18359											
ESPL1	9700	broad.mit.edu	37	chr12	53664560	53664560	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctgtcgggccaagagctGacggaccacatggggatgac	9	5	16	11	2	0	3	0	2	0	1	1	5	0	5	3	5	1	1	3	5	1	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:53664560G>A	uc001sck.2	+	5	1438	c.1347G>A	c.(1345-1347)CTG>CTA	p.L449L	ESPL1_uc001scj.2_Silent_p.L124L	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	449					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GCCAAGAGCTGACGGACCACA	0.547													20	61					0	0	0	0	A	53664560	A	A	53664560	2	1	94	1	0	0	0	0	0	0	0	1	5277	1277	45	2		2	ESPL1	12	53664560	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	623981	53664560	80187335	186	18360											
MBD6	114785	broad.mit.edu	37	chr12	57919424	57919424	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgctatcagcctcaatgctCcctcatacaactggggagct	9	10	8	14	0	3	0	3	0	0	0	4	1	4	1	2	2	6	3	2	2	4	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:57919424C>A	uc001soj.1	+	6	897	c.673C>A	c.(673-675)CCC>ACC	p.P225T	MBD6_uc001sok.1_Missense_Mutation_p.P92T|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	225	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCTCAATGCTCCCTCATACAA	0.652													40	163					2.66277e-13	2.86828e-13	1	0	A	57919424	A	A	57919424	3	1	94	1	0	0	0	0	1	0	0	0	9401	855	30	2	687	2	MBD6	12	57919424	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	4254864	57919424	75932471	187	18361											
USP15	9958	broad.mit.edu	37	chr12	62708688	62708688	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcgaagatttagcaaagctGacacaataggtaatgcaaga	17	8	9	7	1	0	3	0	1	0	2	1	4	0	3	0	1	3	4	0	1	7	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:62708688G>A	uc001src.1	+	4	475	c.466G>A	c.(466-468)GAC>AAC	p.D156N	USP15_uc001srb.1_Missense_Mutation_p.D156N|USP15_uc001sra.2_Missense_Mutation_p.D156N	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	156					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TAGCAAAGCTGACACAATAGG	0.308													34	137					0	0	0	0	A	62708688	A	A	62708688	3	1	94	1	0	0	0	0	1	0	0	0	17114	1290	45	2	480	2	USP15	12	62708688	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	4789264	62708688	71143207	188	18362											
MYBPC1	4604	broad.mit.edu	37	chr12	102025384	102025384	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatagccaaagtcaaggctGaagatcttctgagaaaaccc	15	8	8	10	0	4	3	2	2	2	2	4	4	4	3	2	1	2	1	2	1	6	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:102025384G>A	uc001tii.2	+	5	352	c.250G>A	c.(250-252)GAA>AAA	p.E84K	MYBPC1_uc001tif.1_Missense_Mutation_p.E97K|MYBPC1_uc001tig.2_Missense_Mutation_p.E109K|MYBPC1_uc010svq.1_Missense_Mutation_p.E71K|MYBPC1_uc001tih.2_Missense_Mutation_p.E109K|MYBPC1_uc001tij.2_Missense_Mutation_p.E84K|MYBPC1_uc010svr.1_Missense_Mutation_p.E84K|MYBPC1_uc010svs.1_Missense_Mutation_p.E84K|MYBPC1_uc010svt.1_Missense_Mutation_p.E72K|MYBPC1_uc010svu.1_Missense_Mutation_p.E84K|MYBPC1_uc001tik.2_Missense_Mutation_p.E58K	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	84	Ig-like C2-type 1.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						AGTCAAGGCTGAAGATCTTCT	0.438													15	79					0	0	0	0	A	102025384	A	A	102025384	3	1	94	1	0	0	0	0	1	0	0	0	10064	1291	45	2	351	2	MYBPC1	12	102025384	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	39316696	102025384	31826511	189	18363											
C12orf51	283450	broad.mit.edu	37	chr12	112703016	112703016	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttttgaaaatcatctttaGagacagtttggcacttggtg	10	15	10	6	0	2	2	1	1	1	1	2	3	2	2	0	2	0	3	0	2	3	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:112703016G>C	uc009zwc.2	-	9	1304	c.1286C>G	c.(1285-1287)TCT>TGT	p.S429C	C12orf51_uc010syk.1_Missense_Mutation_p.S252C|C12orf51_uc001tts.2_Missense_Mutation_p.S252C|C12orf51_uc001ttt.3_Missense_Mutation_p.S252C	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						ATCATCTTTAGAGACAGTTTG	0.313													13	40					0	0	0	0	C	112703016	C	C	112703016	3	2	94	1	0	0	0	0	1	0	0	0	1702	942	33	2	10948	2	C12orf51	12	112703016	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	10677632	112703016	21148879	190	18364											
ZMYM2	7750	broad.mit.edu	37	chr13	20601408	20601408	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataccaagccacaatgcctGatggaaaactgtacaacttt	16	9	6	10	0	0	1	0	1	0	0	0	2	0	2	3	1	6	1	3	1	8	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr13:20601408G>C	uc001umr.2	+	10	2099	c.1801G>C	c.(1801-1803)GAT>CAT	p.D601H	ZMYM2_uc001ums.2_Missense_Mutation_p.D601H|ZMYM2_uc001umt.2_Missense_Mutation_p.D601H|ZMYM2_uc010tco.1_RNA|ZMYM2_uc001umv.2_5'UTR|ZMYM2_uc001umw.2_Missense_Mutation_p.D54H	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	601					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CACAATGCCTGATGGAAAACT	0.358													3	3					0	0	0	0	C	20601408	C	C	20601408	3	2	94	1	0	0	0	0	1	0	0	0	17767	1290	45	2	1827	2	ZMYM2	13	20601408	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		20601408	94568470	191	18365											
ATP8A2	51761	broad.mit.edu	37	chr13	26436529	26436529	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggcccaccattcccattgctCcagatatgagaggacaggta	11	8	10	12	0	0	2	0	1	0	2	2	4	2	3	4	3	1	2	4	3	2	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr13:26436529C>G	uc001uqk.2	+	33	3308	c.3166C>G	c.(3166-3168)CCA>GCA	p.P1056A	ATP8A2_uc010tdi.1_Missense_Mutation_p.P991A|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.P606A	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	1016	Extracellular (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TCCCATTGCTCCAGATATGAG	0.532													7	40					0	0	0	0	G	26436529	G	G	26436529	3	3	94	1	0	0	0	0	1	0	0	0	1195	855	30	2	3296	2	ATP8A2	13	26436529	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	5835121	26436529	88733349	192	18366											
STARD13	90627	broad.mit.edu	37	chr13	33701584	33701584	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cggagcagtgagaagcgctgGagcaggctcagctggctggc	8	5	18	10	2	1	1	1	1	0	1	1	4	1	3	0	5	4	6	0	5	1	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr13:33701584G>A	uc001uuw.2	-	6	1974	c.1848C>T	c.(1846-1848)CTC>CTT	p.L616L	STARD13_uc001uuu.2_Silent_p.L608L|STARD13_uc001uuv.2_Silent_p.L498L|STARD13_uc001uux.2_Silent_p.L581L|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Silent_p.L601L	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	616					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AGAAGCGCTGGAGCAGGCTCA	0.642													5	15					0	0	0	0	A	33701584	A	A	33701584	2	1	94	1	0	0	0	0	0	0	0	1	15322	1161	41	2		2	STARD13	13	33701584	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	7265055	33701584	81468294	193	18367											
RB1	5925	broad.mit.edu	37	chr13	48881435	48881435	+	Frame_Shift_Del	DEL	G	-	-																															ggcttgagtttgaagaaacaGaagaacctgattttactgca																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr13:48881435delG	uc001vcb.2	+	2	323	c.157delG	c.(157-159)GAAfs	p.E53fs	RB1_uc010acs.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	53					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(13)|p.?(3)|p.E53K(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGAAGAAACAGAAGAACCTGA	0.328		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			---	---	---								-	48881435	-	-	48881435	7	5	94	1	0	1	0	1	0	0	0	0	13163	943	33	0	163	0	RB1	13	48881435	Frame_Shift_Del	DEL	G	TCGA-CQ-5327-01A-01D-1683-08	15179851	48881435	66288443	194	18368											
GPC5	2262	broad.mit.edu	37	chr13	92101090	92101090	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaggagagatatcagattgCggctcgccaggatatgcagc	11	7	15	8	2	1	2	1	0	0	2	2	6	1	5	1	4	3	2	1	4	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr13:92101090C>T	uc010tif.1	+	2	605	c.239C>T	c.(238-240)GCG>GTG	p.A80V		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	80						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TATCAGATTGCGGCTCGCCAG	0.433													17	50					0	0	0	0	T	92101090	T	T	92101090	3	4	94	1	0	0	0	0	1	0	0	0	6639	768	27	1	245	1	GPC5	13	92101090	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	43219655	92101090	23068788	195	18369											
JUB	84962	broad.mit.edu	37	chr14	23451250	23451250	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcctcaaaggagccgcgctGatttcgctcagcgtccaggg	7	7	13	14	5	2	1	2	1	0	0	4	2	3	2	3	2	2	2	3	2	1	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:23451250G>A	uc001whz.2	-	1	602	c.226C>T	c.(226-228)CAG>TAG	p.Q76*		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	76	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		GAGCCGCGCTGATTTCGCTCA	0.687													5	13					0	0	0	0	A	23451250	A	A	23451250	4	1	94	1	0	0	0	0	0	1	0	0	8007	1299	45	2	1422	2	JUB	14	23451250	Nonsense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		23451250	83898290	196	18370											
JUB	84962	broad.mit.edu	37	chr14	23451383	23451383	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggcgccccttgcccggcccGggggtcccgtcagacccaga	5	4	14	18	4	1	2	1	0	0	2	2	2	2	2	6	4	1	0	6	4	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:23451383G>A	uc001whz.2	-	1	469	c.93C>T	c.(91-93)CCC>CCT	p.P31P		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	31	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		TGCCCGGCCCGGGGGTCCCGT	0.677													7	24					0	0	0	0	A	23451383	A	A	23451383	2	1	94	1	0	0	0	0	0	0	0	1	8007	1103	39	1		1	JUB	14	23451383	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	133	23451383	83898157	197	18371											
IRF9	10379	broad.mit.edu	37	chr14	24633337	24633337	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggagtttctgcttcctccaGagccaggtacgtggcatttc	6	13	11	11	1	1	1	0	0	1	1	4	2	3	2	3	3	3	4	3	3	1	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:24633337G>C	uc001wmq.2	+	6	770	c.643G>C	c.(643-645)GAG>CAG	p.E215Q	RNF31_uc001wmp.2_RNA|IRF9_uc010alj.2_Missense_Mutation_p.E113Q	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	215					interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)		GCTTCCTCCAGAGCCAGGTAC	0.522													36	113					0	0	0	0	C	24633337	C	C	24633337	3	2	94	1	0	0	0	0	1	0	0	0	7876	943	33	2	661	2	IRF9	14	24633337	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1181954	24633337	82716203	198	18372											
AKAP6	9472	broad.mit.edu	37	chr14	33291002	33291002	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagagtctcagtaaagactCttcattttcatctaccaaat	14	14	4	9	0	5	2	3	0	3	2	6	2	5	2	1	0	1	1	1	0	5	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:33291002C>T	uc001wrq.2	+	13	4153	c.3983C>T	c.(3982-3984)TCT>TTT	p.S1328F		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1328					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AGTAAAGACTCTTCATTTTCA	0.428													3	58					0	0	0	0	T	33291002	T	T	33291002	3	4	94	1	0	0	0	0	1	0	0	0	455	913	32	2	4029	2	AKAP6	14	33291002	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	8657665	33291002	74058538	199	18373											
SFRS5	6430	broad.mit.edu	37	chr14	70237755	70237755	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgacttaaagaatgctattGaaaaactttctggaaaggaa	17	11	9	4	0	1	3	0	2	1	1	1	5	1	5	0	2	2	1	0	2	8	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:70237755G>A	uc001xll.2	+	8	1935	c.484G>A	c.(484-486)GAA>AAA	p.E162K	SFRS5_uc001xlm.2_RNA|SFRS5_uc001xlo.2_Missense_Mutation_p.E162K|SFRS5_uc001xlp.2_Missense_Mutation_p.E162K|SFRS5_uc001xlq.2_Missense_Mutation_p.E159K	NM_006925	NP_008856	Q13243	SRSF5_HUMAN	splicing factor, arginine/serine-rich 5	162	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding				0				all cancers(60;0.00144)|BRCA - Breast invasive adenocarcinoma(234;0.0132)|OV - Ovarian serous cystadenocarcinoma(108;0.0154)		GAATGCTATTGAAAAACTTTC	0.328													14	51					0	0	0	0	A	70237755	A	A	70237755	3	1	94	1	0	0	0	0	1	0	0	0	14245	1291	45	2	506	2	SFRS5	14	70237755	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	36946753	70237755	37111785	200	18374											
CKB	1152	broad.mit.edu	37	chr14	103986629	103986629	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatgaactcatagtccttaGacttgaagagagtttcaatc	14	12	7	8	0	2	4	2	2	0	2	4	5	3	4	1	0	1	1	1	0	5	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:103986629G>A	uc001ynf.1	-	7	877	c.797C>T	c.(796-798)TCT>TTT	p.S266F	CKB_uc001yne.1_Missense_Mutation_p.S88F|CKB_uc010awr.1_Missense_Mutation_p.S197F	NM_001823	NP_001814	P12277	KCRB_HUMAN	brain creatine kinase	266	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity				0		Melanoma(154;0.155)	Epithelial(46;0.14)		Creatine(DB00148)	ATAGTCCTTAGACTTGAAGAG	0.567													8	35					0	0	0	0	A	103986629	A	A	103986629	3	1	94	1	0	0	0	0	1	0	0	0	3461	942	33	2	356	2	CKB	14	103986629	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	33748874	103986629	3362911	201	18375											
INF2	64423	broad.mit.edu	37	chr14	105174903	105174903	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccaccatggtggccccccgGgccaggaaggagcccaagga	9	2	14	16	1	0	0	0	0	0	0	0	3	0	3	7	6	1	0	7	6	2	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:105174903G>A	uc001ypb.2	+	9	2009	c.1866G>A	c.(1864-1866)CGG>CGA	p.R622R	INF2_uc010tyi.1_Silent_p.R622R|INF2_uc001ypc.2_Silent_p.R622R|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	622	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		TGGCCCCCCGGGCCAGGAAGG	0.697											OREG0022959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	28					0	0	0	0	A	105174903	A	A	105174903	2	1	94	1	0	0	0	0	0	0	0	1	7773	1219	43	4		4	INF2	14	105174903	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1188274	105174903	2174637	202	18376											
TPM1	7168	broad.mit.edu	37	chr15	63336307	63336307	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatactctgaggctctcaaaGatgcccaggagaagctggag	13	7	12	9	0	2	3	1	1	2	2	3	5	2	4	1	3	3	2	1	3	4	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr15:63336307G>C	uc002alg.2	+	2	387	c.196G>C	c.(196-198)GAT>CAT	p.D66H	TPM1_uc002alh.2_Missense_Mutation_p.D66H|TPM1_uc010bgn.2_RNA|TPM1_uc002ali.2_Missense_Mutation_p.D66H|TPM1_uc002alj.2_Intron|TPM1_uc002alk.2_Missense_Mutation_p.D66H|TPM1_uc002all.2_Intron|TPM1_uc002alm.2_Missense_Mutation_p.D108H|TPM1_uc010uie.1_Intron|TPM1_uc002alp.2_Missense_Mutation_p.D66H	NM_001018005	NP_001018005	P09493	TPM1_HUMAN	tropomyosin 1 alpha chain isoform 1	66	By similarity.				cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle				0						GGCTCTCAAAGATGCCCAGGA	0.567													10	38					0	0	0	0	C	63336307	C	C	63336307	3	2	94	1	0	0	0	0	1	0	0	0	16472	942	33	2	332	2	TPM1	15	63336307	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		63336307	39195085	203	18377											
ADPGK	83440	broad.mit.edu	37	chr15	73048650	73048650	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctccatcatgtgcaatccaGagaggaccaccaggtctggc	10	7	10	14	0	2	1	1	0	1	1	4	3	4	2	5	3	1	1	5	3	1	0	rs142833607	by1000genomes	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr15:73048650G>C	uc002avg.3	-	5	876	c.782C>G	c.(781-783)TCT>TGT	p.S261C	ADPGK_uc002ave.3_5'UTR|ADPGK_uc010ukw.1_Missense_Mutation_p.S203C|ADPGK_uc002avf.3_Missense_Mutation_p.S261C|ADPGK_uc002avi.3_Missense_Mutation_p.S139C|ADPGK_uc002avh.3_Missense_Mutation_p.S22C	NM_031284	NP_112574	Q9BRR6	ADPGK_HUMAN	ADP-dependent glucokinase	261	ADPK.				glycolysis	extracellular region	ADP-specific glucokinase activity|metal ion binding				0						GTGCAATCCAGAGAGGACCAC	0.517													14	67					0	0	0	0	C	73048650	C	C	73048650	3	2	94	1	0	0	0	0	1	0	0	0	330	942	33	2	720	2	ADPGK	15	73048650	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	9712343	73048650	29482742	204	18378											
MESDC1	59274	broad.mit.edu	37	chr15	81295306	81295306	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcggcgctgctggcctgcGtgcgcgaggtgaaggtggcg	3	7	20	11	7	0	1	0	1	0	0	1	2	0	1	1	5	3	2	1	5	1	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr15:81295306G>A	uc002bfz.2	+	1	2012	c.694G>A	c.(694-696)GTG>ATG	p.V232M		NM_022566	NP_072088	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	232											0						GCTGGCCTGCGTGCGCGAGGT	0.697													4	16					0	0	0	0	A	81295306	A	A	81295306	3	1	94	1	0	0	0	0	1	0	0	0	9533	1145	40	1	696	1	MESDC1	15	81295306	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	8246656	81295306	21236086	205	18379											
HN1L	90861	broad.mit.edu	37	chr16	1741947	1741947	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacatttttgggtctccggtCactgccacttcacgcttggc	5	13	10	13	2	3	0	2	0	1	0	4	1	3	0	2	3	1	1	2	3	0	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:1741947C>T	uc002cmg.2	+	3	333	c.297C>T	c.(295-297)GTC>GTT	p.V99V	HN1L_uc010uvi.1_Silent_p.V127V|HN1L_uc010brt.2_RNA|HN1L_uc010bru.2_Intron|HN1L_uc010uvj.1_Intron|HN1L_uc010uvk.1_Silent_p.V86V	NM_144570	NP_653171	Q9H910	HN1L_HUMAN	hematological and neurological expressed 1-like	99						cytoplasm|nucleus				upper_aerodigestive_tract(1)	1						GGTCTCCGGTCACTGCCACTT	0.542													15	46					0	0	0	0	T	1741947	T	T	1741947	2	4	94	1	0	0	0	0	0	0	0	1	7289	813	29	2		2	HN1L	16	1741947	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08		1741947	88612806	206	18380											
CP110	9738	broad.mit.edu	37	chr16	19548342	19548342	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaatacatctgaagtcaaaGaagatgtggttttaggtaaa	18	11	9	3	0	2	3	1	1	1	2	2	3	2	3	0	2	1	2	0	2	9	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:19548342G>A	uc002dgl.3	+	4	1598	c.1351G>A	c.(1351-1353)GAA>AAA	p.E451K	CP110_uc002dgk.3_Missense_Mutation_p.E451K			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	451	Interaction with CEP76.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						TGAAGTCAAAGAAGATGTGGT	0.358													13	70					0	0	0	0	A	19548342	A	A	19548342	3	1	94	1	0	0	0	0	1	0	0	0	3803	943	33	2	1361	2	CP110	16	19548342	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	17806395	19548342	70806411	207	18381											
DNAH3	55567	broad.mit.edu	37	chr16	21011751	21011751	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagtgcctgtgggacccacGaacagcattggaatctcatg	10	8	11	12	1	1	0	1	0	1	0	2	3	1	2	3	2	3	1	3	2	2	1	rs138378920		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:21011751G>A	uc010vbe.1	-	43	6216	c.6216C>T	c.(6214-6216)TTC>TTT	p.F2072F		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2072	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TGGGACCCACGAACAGCATTG	0.493													14	32					0	0	0	0	A	21011751	A	A	21011751	2	1	94	1	0	0	0	0	0	0	0	1	4625	1049	37	1		1	DNAH3	16	21011751	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1463409	21011751	69343002	208	18382											
UBFD1	56061	broad.mit.edu	37	chr16	23570850	23570850	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccccgaggataaaacattGagagaaataaaagtgaccag	18	6	10	7	1	0	3	0	2	0	1	1	6	1	4	3	1	1	0	3	1	5	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:23570850G>A	uc002dlv.2	+	3	619	c.417G>A	c.(415-417)TTG>TTA	p.L139L	EARS2_uc002dls.3_5'Flank|EARS2_uc002dlt.3_5'Flank|EARS2_uc002dlu.2_5'Flank	NM_019116	NP_061989	O14562	UBFD1_HUMAN	ubiquitin-binding protein homolog	139	Ubiquitin-like.										0				GBM - Glioblastoma multiforme(48;0.0331)		ATAAAACATTGAGAGAAATAA	0.483													5	27					0	0	0	0	A	23570850	A	A	23570850	2	1	94	1	0	0	0	0	0	0	0	1	16952	1281	45	2		2	UBFD1	16	23570850	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	2559099	23570850	66783903	209	18383											
NKD1	85407	broad.mit.edu	37	chr16	50667367	50667367	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtgtgggccacgtggccaGaggggcaagaaacaagcccc	10	3	17	11	1	0	2	0	0	0	2	0	2	0	2	4	5	2	1	4	5	3	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:50667367G>C	uc002egg.1	+	10	1312	c.1088G>C	c.(1087-1089)AGA>ACA	p.R363T		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	363					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		CACGTGGCCAGAGGGGCAAGA	0.711													8	30					0	0	0	0	C	50667367	C	C	50667367	3	2	94	1	0	0	0	0	1	0	0	0	10495	942	33	2	1126	2	NKD1	16	50667367	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	27096517	50667367	39687386	210	18384											
CES3	23491	broad.mit.edu	37	chr16	67005131	67005131	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatacctaggaagcaactcGgacgcacaagccaaatgcca	16	4	9	12	2	0	0	0	0	0	0	1	3	0	2	3	2	5	2	3	2	7	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:67005131G>T	uc002eqt.2	+	10	1273	c.1200G>T	c.(1198-1200)TCG>TCT	p.S400S	CES3_uc010cdz.2_Silent_p.S400S|CES3_uc010cea.2_Intron|CES3_uc010viw.1_Silent_p.S39S	NM_024922	NP_079198	Q6UWW8	EST3_HUMAN	carboxylesterase 3 precursor	400						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			ovary(3)|central_nervous_system(2)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GAAGCAACTCGGACGCACAAG	0.537													16	33					2.32078e-09	2.46679e-09	1	0	T	67005131	T	T	67005131	2	4	94	1	0	0	0	0	0	0	0	1	3286	1103	39	3		3	CES3	16	67005131	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	16337764	67005131	23349622	211	18385											
CTCF	10664	broad.mit.edu	37	chr16	67662366	67662366	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttccgccagaagcagcttCtcgacatgcacttcaagcgc	9	8	8	16	3	2	1	1	0	1	1	4	2	3	1	3	0	4	3	3	0	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:67662366C>G	uc002etl.2	+	9	1902	c.1612C>G	c.(1612-1614)CTC>GTC	p.L538V	CTCF_uc010cek.2_Missense_Mutation_p.L210V|CTCF_uc002etm.1_Missense_Mutation_p.L27V	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	538	C2H2-type 10.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		GAAGCAGCTTCTCGACATGCA	0.547													34	62					0	0	0	0	G	67662366	G	G	67662366	3	3	94	1	0	0	0	0	1	0	0	0	4017	913	32	2	1638	2	CTCF	16	67662366	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	657235	67662366	22692387	212	18386											
CTCF	10664	broad.mit.edu	37	chr16	67662427	67662427	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctgcggcttttgtctgttCtaagtgtgggaaaacattta	8	15	10	8	1	2	0	0	0	2	0	2	1	2	1	1	2	2	2	1	2	4	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:67662427C>G	uc002etl.2	+	9	1963	c.1673C>G	c.(1672-1674)TCT>TGT	p.S558C	CTCF_uc010cek.2_Missense_Mutation_p.S230C|CTCF_uc002etm.1_Missense_Mutation_p.S47C	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	558	C2H2-type 11; atypical.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		TTTGTCTGTTCTAAGTGTGGG	0.483													37	76					0	0	0	0	G	67662427	G	G	67662427	3	3	94	1	0	0	0	0	1	0	0	0	4017	913	32	2	1699	2	CTCF	16	67662427	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	61	67662427	22692326	213	18387											
EDC4	23644	broad.mit.edu	37	chr16	67912724	67912724	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagcagaatacctgattctCagcgatgtgcaacggaaggt	12	9	11	9	2	2	2	2	1	1	1	3	4	2	3	1	2	5	2	1	2	4	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:67912724C>T	uc002eur.2	+	11	1435	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L	EDC4_uc010cer.2_Silent_p.L42L|EDC4_uc010vkg.1_Silent_p.L355L|EDC4_uc010ces.1_Silent_p.L266L|EDC4_uc002eus.2_Silent_p.L153L	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	423					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		ACCTGATTCTCAGCGATGTGC	0.567													38	106					0	0	0	0	T	67912724	T	T	67912724	2	4	94	1	0	0	0	0	0	0	0	1	4930	813	29	2		2	EDC4	16	67912724	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	250297	67912724	22442029	214	18388											
MYO15A	51168	broad.mit.edu	37	chr17	18045516	18045516	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaagcggcgattccgctctCtgcgccacaagatcatcctg	8	10	9	14	4	2	1	1	0	1	1	5	2	4	1	3	1	2	1	3	1	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:18045516C>T	uc010vxh.1	+	23	6111	c.5773C>T	c.(5773-5775)CTG>TTG	p.L1925L		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1925	Neck or regulatory domain.|IQ 2.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					ATTCCGCTCTCTGCGCCACAA	0.592													8	24					0	0	0	0	T	18045516	T	T	18045516	2	4	94	1	0	0	0	0	0	0	0	1	10116	912	32	2		2	MYO15A	17	18045516	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08		18045516	63149694	215	18389											
SARM1	23098	broad.mit.edu	37	chr17	26715421	26715421	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcagtgtcttcattgatgtgGagaagctggaagcaggcaag	11	10	14	6	0	3	2	2	1	1	1	3	4	3	3	0	3	2	3	0	3	3	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:26715421G>A	uc010crl.1	+	10	1853	c.1786G>A	c.(1786-1788)GAG>AAG	p.E596K	SARM1_uc010waj.1_RNA|SARM1_uc002hbe.1_Missense_Mutation_p.E140K	NM_015077	NP_055892	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	596	TIR.				innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CATTGATGTGGAGAAGCTGGA	0.552													14	70					0	0	0	0	A	26715421	A	A	26715421	3	1	94	1	0	0	0	0	1	0	0	0	13907	1175	41	2	1810	2	SARM1	17	26715421	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	8669905	26715421	54479789	216	18390											
NR1D1	9572	broad.mit.edu	37	chr17	38251870	38251870	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtaggaggagggagcctggcGcagaccatttagggcctcgt	8	7	17	9	2	0	1	0	0	0	1	1	4	0	4	3	5	1	2	3	5	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:38251870G>A	uc002htz.1	-	5	1701	c.1075C>T	c.(1075-1077)CGC>TGC	p.R359C	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_Intron	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	359					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					GGAGCCTGGCGCAGACCATTT	0.637													4	84					0	0	0	0	A	38251870	A	A	38251870	3	1	94	1	0	0	0	0	1	0	0	0	10669	1087	38	1	785	1	NR1D1	17	38251870	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	11536449	38251870	42943340	217	18391											
KRT37	8688	broad.mit.edu	37	chr17	39580458	39580458	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcattcaggaacttcatggtCtccttctcatggccattcag	8	14	7	12	0	6	0	5	0	2	0	8	1	6	1	2	3	1	0	2	3	1	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:39580458C>T	uc002hwp.1	-	1	365	c.318G>A	c.(316-318)GAG>GAA	p.E106E	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	106	Coil 1A.|Rod.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				ACTTCATGGTCTCCTTCTCAT	0.572													13	54					0	0	0	0	T	39580458	T	T	39580458	2	4	94	1	0	0	0	0	0	0	0	1	8513	912	32	2		2	KRT37	17	39580458	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	1328588	39580458	41614752	218	18392											
ACLY	47	broad.mit.edu	37	chr17	40063716	40063716	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctggatatgcctcccgcccGaaggggggagggaactcgat	8	7	15	11	3	1	0	0	0	1	0	3	5	2	3	3	5	2	0	3	5	3	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:40063716G>A	uc002hyg.2	-	7	889	c.726C>T	c.(724-726)TTC>TTT	p.F242F	ACLY_uc002hyh.2_Silent_p.F242F|ACLY_uc002hyi.2_Silent_p.F296F|ACLY_uc010wfx.1_Silent_p.F296F|ACLY_uc010wfy.1_Intron	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	242					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CCTCCCGCCCGAAGGGGGGAG	0.582													4	72					0	0	0	0	A	40063716	A	A	40063716	2	1	94	1	0	0	0	0	0	0	0	1	143	1049	37	1		1	ACLY	17	40063716	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	483258	40063716	41131494	219	18393											
MAPT	4137	broad.mit.edu	37	chr17	44061080	44061080	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccccctggagttcacgtttCacgtggaaatcacacccaac	10	8	7	16	2	3	0	3	0	0	0	3	2	3	2	4	2	1	2	4	2	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:44061080C>G	uc002ijr.3	+	6	1230	c.910C>G	c.(910-912)CAC>GAC	p.H304D	MAPT_uc010dau.2_Missense_Mutation_p.H304D|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	304					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				GTTCACGTTTCACGTGGAAAT	0.622													12	61					0	0	0	0	G	44061080	G	G	44061080	3	3	94	1	0	0	0	0	1	0	0	0	9350	826	29	2	928	2	MAPT	17	44061080	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	3997364	44061080	37134130	220	18394											
CA4	762	broad.mit.edu	37	chr17	58235751	58235751	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactcaccacaccgacctgcGatgagaaggtcgtctggact	10	7	10	14	3	2	1	1	1	1	1	3	5	2	2	3	2	1	0	3	2	1	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:58235751G>A	uc002iym.3	+	7	782	c.688G>A	c.(688-690)GAT>AAT	p.D230N	CA4_uc010wou.1_RNA	NM_000717	NP_000708	P22748	CAH4_HUMAN	carbonic anhydrase IV precursor	230					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	ACCGACCTGCGATGAGAAGGT	0.612													11	32					0	0	0	0	A	58235751	A	A	58235751	3	1	94	1	0	0	0	0	1	0	0	0	2530	1058	37	1	714	1	CA4	17	58235751	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	14174671	58235751	22959459	221	18395											
UNC13D	201294	broad.mit.edu	37	chr17	73831829	73831829	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacactacatcacccacaacCgtcgtgtggtcctgcacccg	9	7	8	17	3	1	0	1	0	0	0	3	1	2	0	4	1	3	1	4	1	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:73831829C>T	uc002jpp.2	-	19	2006	c.1626G>A	c.(1624-1626)ACG>ACA	p.T542T	UNC13D_uc010wsk.1_Silent_p.T542T|UNC13D_uc002jpq.1_Silent_p.T192T	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	542	Interaction with RAB27A.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			CACCCACAACCGTCGTGTGGT	0.622									Familial_Hemophagocytic_Lymphohistiocytosis				30	69					0	0	0	0	T	73831829	T	T	73831829	2	4	94	1	0	0	0	0	0	0	0	1	17055	639	23	1		1	UNC13D	17	73831829	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	15596078	73831829	7363381	222	18396											
CDK3	1018	broad.mit.edu	37	chr17	73998157	73998157	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatctggtgtttgagttcctCagccaggacctgaagaagta	10	12	11	8	0	2	3	1	2	1	1	3	4	3	4	3	2	1	3	3	2	4	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:73998157C>T	uc010dgt.2	+	4	325	c.249C>T	c.(247-249)CTC>CTT	p.L83L	CDK3_uc002jqg.3_Silent_p.L111L	NM_001258	NP_001249	Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	83	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						TTGAGTTCCTCAGCCAGGACC	0.572													14	54					0	0	0	0	T	73998157	T	T	73998157	2	4	94	1	0	0	0	0	0	0	0	1	3155	813	29	2		2	CDK3	17	73998157	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	166328	73998157	7197053	223	18397											
ENGASE	64772	broad.mit.edu	37	chr17	77070997	77070998	+	5'Flank	INS	-	A	A																															ggggcgggcccgggcctgcgINSattgcctctcggcgtgcgcg																										TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:77070997_77070998insA	uc002jwv.2	+						ENGASE_uc002jwu.1_5'Flank|ENGASE_uc010wtz.1_5'Flank	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase							cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						ccgggccTGCGATTGCCTCTCG	0.366													---	---	---								A	77070998	A	A	77070997	6	5	94	0	1	1	1	0	0	0	0	0	5142	1073	37	0		0	ENGASE	17	77070997	5'Flank	INS	-	TCGA-CQ-5327-01A-01D-1683-08	3072840	77070997	4124213	224	18398											
MYOM1	8736	broad.mit.edu	37	chr18	3129359	3129359	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctgtttggcccaggttttGagagctactgggtagtgaag	7	14	14	6	0	1	2	0	2	1	1	1	3	1	2	1	3	2	4	1	3	3	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr18:3129359G>C	uc002klp.2	-	18	2999	c.2665C>G	c.(2665-2667)CAA>GAA	p.Q889E	MYOM1_uc002klq.2_Intron	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	889						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CCCAGGTTTTGAGAGCTACTG	0.532											OREG0024838	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	114					0	0	0	0	C	3129359	C	C	3129359	3	2	94	1	0	0	0	0	1	0	0	0	10144	1299	45	2	2476	2	MYOM1	18	3129359	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		3129359	74947889	225	18399											
PTPRM	5797	broad.mit.edu	37	chr18	7955287	7955287	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcagccagtcgattccaCgagctataaaattggacacc	12	7	9	13	3	0	0	0	0	0	0	2	3	1	1	4	2	2	2	4	2	3	4	rs150274533	by1000genomes	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr18:7955287C>T	uc002knn.3	+	7	1510	c.1007C>T	c.(1006-1008)ACG>ATG	p.T336M	PTPRM_uc010dkv.2_Missense_Mutation_p.T336M|PTPRM_uc010wzl.1_Missense_Mutation_p.T123M	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	336	Fibronectin type-III 1.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GTCGATTCCACGAGCTATAAA	0.572													6	30					0	0	0	0	T	7955287	T	T	7955287	3	4	94	1	0	0	0	0	1	0	0	0	12871	536	19	1	1033	1	PTPRM	18	7955287	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	4825928	7955287	70121961	226	18400											
MC4R	4160	broad.mit.edu	37	chr18	58039474	58039474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctcgtagcaccctccatCagagtagccttttccaaggg	8	11	9	13	1	1	1	1	0	0	1	4	1	3	1	4	1	3	4	4	1	3	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr18:58039474C>T	uc002lie.1	-	1	528	c.109G>A	c.(109-111)GAT>AAT	p.D37N		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	37	Extracellular (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				CACCCTCCATCAGAGTAGCCT	0.512													15	44					0	0	0	0	T	58039474	T	T	58039474	3	4	94	1	0	0	0	0	1	0	0	0	9419	826	29	2	893	2	MC4R	18	58039474	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	50084187	58039474	20037774	227	18401											
CDH19	28513	broad.mit.edu	37	chr18	64176484	64176484	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaatgacagctgtgttatCtaaaacaaaaatccatgtgc	17	10	6	8	0	1	1	0	1	1	0	2	1	2	1	1	0	3	2	1	0	7	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr18:64176484C>G	uc002lkc.1	-	11	1715	c.1577_splice	c.e11-1	p.D526_splice	CDH19_uc010dql.1_Intron|CDH19_uc010xey.1_Intron	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				GCTGTGTTATCTAAAACAAAA	0.343													9	17					0	0	0	0	G	64176484	G	G	64176484	5	3	94	1	0	0	0	0	0	0	1	0	3119	927	32	2	750	2	CDH19	18	64176484	Splice_Site	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	6137010	64176484	13900764	228	18402											
CNDP2	55748	broad.mit.edu	37	chr18	72180833	72180833	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggggaacatcctgatccccgGcattaacgaggccgtggccg	8	6	14	13	4	0	1	0	1	0	0	2	3	2	2	5	5	2	1	5	5	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr18:72180833G>A	uc002llm.1	+	8	944	c.782G>A	c.(781-783)GGC>GAC	p.G261D	CNDP2_uc002lln.1_Missense_Mutation_p.G177D|CNDP2_uc010dqs.2_Intron	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	261						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		CTGATCCCCGGCATTAACGAG	0.607													3	30					0	0	0	0	A	72180833	A	A	72180833	3	1	94	1	0	0	0	0	1	0	0	0	3609	1203	42	4	808	4	CNDP2	18	72180833	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	8004349	72180833	5896415	229	18403											
TICAM1	148022	broad.mit.edu	37	chr19	4817044	4817044	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagtaggatgatgaaagctGagtggtctatggcgtcctgc	10	10	15	6	1	1	3	0	3	1	0	2	5	2	4	1	3	2	2	1	3	4	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:4817044G>A	uc002mbi.2	-	2	1597	c.1346C>T	c.(1345-1347)TCA>TTA	p.S449L		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	449	TIR.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GATGAAAGCTGAGTGGTCTAT	0.632													8	57					0	0	0	0	A	4817044	A	A	4817044	3	1	94	1	0	0	0	0	1	0	0	0	15958	1294	45	2	796	2	TICAM1	19	4817044	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		4817044	54311939	230	18404											
KDM4B	23030	broad.mit.edu	37	chr19	5131326	5131326	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgcccagtgaggagctaGaggccaagcctcggcccatc	9	5	14	13	1	0	2	0	1	0	1	2	3	0	3	4	4	3	1	4	4	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:5131326G>A	uc002mbq.3	+	12	1781	c.1555G>A	c.(1555-1557)GAG>AAG	p.E519K	KDM4B_uc010xim.1_Missense_Mutation_p.E553K|KDM4B_uc002mbr.3_Missense_Mutation_p.E277K	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	519	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						TGAGGAGCTAGAGGCCAAGCC	0.687													8	26					0	0	0	0	A	5131326	A	A	5131326	3	1	94	1	0	0	0	0	1	0	0	0	8168	943	33	2	1593	2	KDM4B	19	5131326	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	314282	5131326	53997657	231	18405											
TUBB4	10382	broad.mit.edu	37	chr19	6495568	6495568	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgcggccccggaacacggcGgccacggtcaggtagcggcc	7	3	16	15	6	1	0	1	0	0	0	1	1	1	1	4	7	3	1	4	7	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:6495568G>A	uc002mfg.1	-	4	1049	c.942C>T	c.(940-942)GCC>GCT	p.A314A	TUBB4_uc002mff.1_Silent_p.A242A|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	314					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		GGAACACGGCGGCCACGGTCA	0.647													24	99					0	0	0	0	A	6495568	A	A	6495568	2	1	94	1	0	0	0	0	0	0	0	1	16826	1103	39	1		1	TUBB4	19	6495568	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1364242	6495568	52633415	232	18406											
MAP2K7	5609	broad.mit.edu	37	chr19	7968931	7968931	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgacctcaacctggatatCagcccccagcggcccaggcc	9	5	9	18	2	2	0	2	0	0	0	3	2	2	1	6	3	3	0	6	3	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:7968931C>T	uc002mit.2	+	1	167	c.102C>T	c.(100-102)ATC>ATT	p.I34I	MAP2K7_uc002mis.1_Silent_p.I34I|MAP2K7_uc002miv.2_Silent_p.I34I|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Silent_p.I34I|MAP2K7_uc010dvv.2_5'UTR	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	34					activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	ACCTGGATATCAGCCCCCAGC	0.398													5	12					0	0	0	0	T	7968931	T	T	7968931	2	4	94	1	0	0	0	0	0	0	0	1	9295	816	29	2		2	MAP2K7	19	7968931	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	1473363	7968931	51160052	233	18407											
MUC16	94025	broad.mit.edu	37	chr19	9066948	9066948	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaggctaggggtgagcagtGaggtcataggagaaggagtg	11	7	19	4	0	1	3	1	2	0	1	1	5	1	4	0	6	1	2	0	6	4	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:9066948G>A	uc002mkp.2	-	3	20702	c.20498C>T	c.(20497-20499)TCA>TTA	p.S6833L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6835	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGAGCAGTGAGGTCATAGG	0.502													10	62					0	0	0	0	A	9066948	A	A	9066948	3	1	94	1	0	0	0	0	1	0	0	0	10026	1294	45	2	23353	2	MUC16	19	9066948	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1098017	9066948	50062035	234	18408											
SLC44A2	57153	broad.mit.edu	37	chr19	10747142	10747142	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcttctggttggccaacttCgtgctggcgctgggccaggt	3	13	14	11	2	2	0	0	0	2	0	3	0	2	0	2	5	2	3	2	5	1	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:10747142C>T	uc002mpf.2	+	15	1516	c.1377C>T	c.(1375-1377)TTC>TTT	p.F459F	SLC44A2_uc002mpe.3_Silent_p.F457F|SLC44A2_uc002mpg.1_Silent_p.F179F|SLC44A2_uc002mph.2_Silent_p.F8F	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	459	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	TGGCCAACTTCGTGCTGGCGC	0.647													34	76					0	0	0	0	T	10747142	T	T	10747142	2	4	94	1	0	0	0	0	0	0	0	1	14700	883	31	1		1	SLC44A2	19	10747142	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	1680194	10747142	48381841	235	18409											
ZNF490	57474	broad.mit.edu	37	chr19	12721450	12721450	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgctctggacttgctcctcGaggggtcgctccatctggaa	5	12	12	12	2	2	0	0	0	2	0	6	3	4	2	2	4	2	3	2	4	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:12721450G>A	uc002mtz.2	-	1	174	c.45C>T	c.(43-45)CTC>CTT	p.L15L	ZNF791_uc002mua.2_5'Flank|ZNF791_uc010xml.1_5'Flank|ZNF791_uc010dyu.1_5'Flank|ZNF791_uc010xmm.1_5'Flank	NM_020714	NP_065765	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTGCTCCTCGAGGGGTCGCT	0.567													14	30					0	0	0	0	A	12721450	A	A	12721450	2	1	94	1	0	0	0	0	0	0	0	1	18008	1045	37	1		1	ZNF490	19	12721450	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1974308	12721450	46407533	236	18410											
ZSWIM4	65249	broad.mit.edu	37	chr19	13915816	13915816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggagctgcggctgcccatctCcgagacgctctcccagatga	7	7	12	15	3	2	3	0	1	2	2	4	5	2	4	3	2	3	3	3	2	0	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:13915816C>T	uc002mxh.1	+	3	755	c.566C>T	c.(565-567)TCC>TTC	p.S189F	ZSWIM4_uc010xng.1_5'UTR	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	189							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CTGCCCATCTCCGAGACGCTC	0.637											OREG0025298	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	39					0	0	0	0	T	13915816	T	T	13915816	3	4	94	1	0	0	0	0	1	0	0	0	18310	855	30	2	576	2	ZSWIM4	19	13915816	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	1194366	13915816	45213167	237	18411											
SAMD1	90378	broad.mit.edu	37	chr19	14199324	14199324	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcagggctggcccgaggcGgatggacaggccggtgagca	7	6	18	10	3	1	1	1	1	0	0	1	4	1	3	2	7	1	2	2	7	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:14199324G>A	uc010xnl.1	-	7	1522	c.1522C>T	c.(1522-1524)CGC>TGC	p.R508C		NM_138352	NP_612361	Q6SPF0	SAMD1_HUMAN	sterile alpha motif domain containing 1	508	SAM.					cytoplasm|extracellular region					0		Renal(1328;0.00183)|Hepatocellular(1079;0.00826)		GBM - Glioblastoma multiforme(1328;0.000411)|STAD - Stomach adenocarcinoma(1328;0.00644)|Lung(535;0.199)		GGCCCGAGGCGGATGGACAGG	0.577													10	36					0	0	0	0	A	14199324	A	A	14199324	3	1	94	1	0	0	0	0	1	0	0	0	13879	1116	39	1	97	1	SAMD1	19	14199324	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	283508	14199324	44929659	238	18412											
SIN3B	23309	broad.mit.edu	37	chr19	16980676	16980676	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccccgcacaagcccctggacGatgtctacagcctatttttt	8	11	7	15	2	1	0	0	0	1	0	1	2	1	1	5	1	3	1	5	1	3	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:16980676G>A	uc002ney.1	+	14	2322	c.2308G>A	c.(2308-2310)GAT>AAT	p.D770N	SIN3B_uc002nez.1_Missense_Mutation_p.D738N|SIN3B_uc010xpi.1_Missense_Mutation_p.D328N	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	770					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						GCCCCTGGACGATGTCTACAG	0.642													7	25					0	0	0	0	A	16980676	A	A	16980676	3	1	94	1	0	0	0	0	1	0	0	0	14391	1058	37	1	2362	1	SIN3B	19	16980676	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	2781352	16980676	42148307	239	18413											
KIRREL2	84063	broad.mit.edu	37	chr19	36357325	36357325	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcccccagatctggccccCgggactccccccttcccata	5	6	9	21	1	1	1	0	0	1	1	3	2	3	2	8	3	0	0	8	3	1	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:36357325C>T	uc002ocb.3	+	15	2270	c.2058C>T	c.(2056-2058)CCC>CCT	p.P686P	KIRREL2_uc002obz.3_Intron|KIRREL2_uc002oca.3_Intron|KIRREL2_uc002occ.3_Silent_p.P633P|KIRREL2_uc002ocd.3_Silent_p.P648P|APLP1_uc010xsz.1_5'Flank|APLP1_uc002oce.2_5'Flank|APLP1_uc002ocf.2_5'Flank|APLP1_uc002ocg.2_5'Flank	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	686	Pro-rich.|Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATCTGGCCCCCGGGACTCCCC	0.592													26	71					0	0	0	0	T	36357325	T	T	36357325	2	4	94	1	0	0	0	0	0	0	0	1	8364	639	23	1		1	KIRREL2	19	36357325	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	19376649	36357325	22771658	240	18414											
WDR62	284403	broad.mit.edu	37	chr19	36558321	36558321	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgccatgtgaggttctggttCttggaagtctccactgagac	7	12	12	10	1	3	2	0	2	3	1	4	4	3	3	2	3	0	2	2	3	1	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:36558321C>T	uc002odc.2	+	6	766	c.675C>T	c.(673-675)TTC>TTT	p.F225F	WDR62_uc002odd.2_Silent_p.F225F|WDR62_uc002odb.2_Silent_p.F225F	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	225	WD 3.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGTTCTGGTTCTTGGAAGTCT	0.532													8	56					0	0	0	0	T	36558321	T	T	36558321	2	4	94	1	0	0	0	0	0	0	0	1	17381	912	32	2		2	WDR62	19	36558321	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	200996	36558321	22570662	241	18415											
ZNF568	374900	broad.mit.edu	37	chr19	37440743	37440743	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtaatcagtgtggacaaGacttcagtcataaatttgac	14	12	9	6	0	3	2	3	1	0	1	3	3	3	3	0	1	0	1	0	1	4	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:37440743G>T	uc002ofc.2	+	7	1203	c.688G>T	c.(688-690)GAC>TAC	p.D230Y	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.D154Y|ZNF568_uc010efe.2_Missense_Mutation_p.D154Y|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	230	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTGTGGACAAGACTTCAGTCA	0.398													14	72					2.61681e-11	2.80936e-11	1	0	T	37440743	T	T	37440743	3	4	94	1	0	0	0	0	1	0	0	0	18066	942	33	2	706	2	ZNF568	19	37440743	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	882422	37440743	21688240	242	18416											
LGALS4	3960	broad.mit.edu	37	chr19	39299490	39299490	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacttcccgccctgcaacGtgttgaagaccaccttgtcc	7	9	7	18	2	0	2	0	1	0	1	2	2	2	2	6	0	2	2	6	0	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:39299490G>A	uc002ojg.2	-	3	447	c.233C>T	c.(232-234)ACG>ATG	p.T78M	LGALS4_uc010xuj.1_Missense_Mutation_p.T78M	NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	78	Galectin 1.				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GCCCTGCAACGTGTTGAAGAC	0.582													11	37					0	0	0	0	A	39299490	A	A	39299490	3	1	94	1	0	0	0	0	1	0	0	0	8785	1145	40	1	770	1	LGALS4	19	39299490	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1858747	39299490	19829493	243	18417											
PSG6	5675	broad.mit.edu	37	chr19	43421931	43421931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgagtgcagggaggggctGagaggggtcccatggtctct	6	8	19	8	0	1	2	0	2	1	1	3	4	2	3	1	6	1	3	1	6	0	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:43421931G>A	uc002ovj.1	-	1	66	c.14C>T	c.(13-15)TCA>TTA	p.S5L	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ovf.1_Missense_Mutation_p.S5L|PSG6_uc002ovg.1_Missense_Mutation_p.S5L	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	5					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GGGAGGGGCTGAGAGGGGTCC	0.597													31	101					0	0	0	0	A	43421931	A	A	43421931	3	1	94	1	0	0	0	0	1	0	0	0	12721	1294	45	2	1356	2	PSG6	19	43421931	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	4122441	43421931	15707052	244	18418											
CD3EAP	10849	broad.mit.edu	37	chr19	45910392	45910392	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccccaactttaccgcgaaGcccccagcctcagagtcccc	8	5	6	22	2	1	1	1	0	0	1	2	2	2	1	9	0	4	0	9	0	3	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:45910392G>A	uc002pbq.1	+	2	551	c.63G>A	c.(61-63)AAG>AAA	p.K21K	PPP1R13L_uc002pbn.2_5'Flank|PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Silent_p.K23K	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	21					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		TTACCGCGAAGCCCCCAGCCT	0.597													17	60					0	0	0	0	A	45910392	A	A	45910392	2	1	94	1	0	0	0	0	0	0	0	1	3027	962	34	4		4	CD3EAP	19	45910392	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	2488461	45910392	13218591	245	18419											
FUT2	2524	broad.mit.edu	37	chr19	49206875	49206875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggggtggtggccgaccggcGatacctacagcaggccctgg	6	5	18	12	3	0	0	0	0	0	0	0	2	0	0	4	7	3	1	4	7	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:49206875G>A	uc002pke.3	+	2	773	c.662G>A	c.(661-663)CGA>CAA	p.R221Q	FUT2_uc010emc.2_Missense_Mutation_p.R221Q	NM_001097638	NP_001091107	Q10981	FUT2_HUMAN	fucosyltransferase 2	221	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity	p.R221*(1)		central_nervous_system(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		GCCGACCGGCGATACCTACAG	0.607													23	95					0	0	0	0	A	49206875	A	A	49206875	3	1	94	1	0	0	0	0	1	0	0	0	6138	1058	37	1	664	1	FUT2	19	49206875	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	3296483	49206875	9922108	246	18420											
SIGLEC6	946	broad.mit.edu	37	chr19	52033148	52033148	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaccagctcaggtgtgcaGgggggttgccgtcagcatca	8	7	16	10	1	3	0	3	0	0	0	3	1	3	1	2	5	5	4	2	5	1	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:52033148G>A	uc002pwy.2	-	5	1004	c.842C>T	c.(841-843)CCT>CTT	p.P281L	SIGLEC6_uc002pwz.2_Missense_Mutation_p.P265L|SIGLEC6_uc002pxa.2_Missense_Mutation_p.P281L|SIGLEC6_uc010ydb.1_Missense_Mutation_p.P218L|SIGLEC6_uc010ydc.1_Missense_Mutation_p.P281L|SIGLEC6_uc010eoz.1_Missense_Mutation_p.P259L|SIGLEC6_uc010epb.1_Missense_Mutation_p.P234L|SIGLEC6_uc010epa.1_Missense_Mutation_p.P270L	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	281	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CAGGTGTGCAGGGGGGTTGCC	0.617													18	70					0	0	0	0	A	52033148	A	A	52033148	3	1	94	1	0	0	0	0	1	0	0	0	14377	1000	35	4	535	4	SIGLEC6	19	52033148	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	2826273	52033148	7095835	247	18421											
FPR2	2358	broad.mit.edu	37	chr19	52272800	52272800	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccttcttcaacagctgcCtcaaccccatgctttacgtc	7	12	6	16	1	3	0	2	0	1	0	4	0	3	0	4	1	6	2	4	1	3	4			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:52272800C>T	uc002pxr.2	+	2	934	c.889C>T	c.(889-891)CTC>TTC	p.L297F	FPR2_uc002pxs.3_Missense_Mutation_p.L297F|FPR2_uc010epf.2_Missense_Mutation_p.L297F	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	297	Helical; Name=7; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						CAACAGCTGCCTCAACCCCAT	0.542													23	52					0	0	0	0	T	52272800	T	T	52272800	3	4	94	1	0	0	0	0	1	0	0	0	6073	681	24	4	891	4	FPR2	19	52272800	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	239652	52272800	6856183	248	18422											
ZNF580	51157	broad.mit.edu	37	chr19	56154207	56154207	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcggctgcagagccaccgCgtgtcgcactcggacctcaa	7	6	12	16	5	1	1	1	0	0	1	3	2	1	2	3	2	3	3	3	2	1	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:56154207C>T	uc002qlo.2	+	2	503	c.333C>T	c.(331-333)CGC>CGT	p.R111R	ZNF580_uc002qlm.2_Silent_p.R124R|ZNF581_uc002qln.2_Intron|ZNF580_uc002qlp.2_Silent_p.R111R|ZNF580_uc010ygd.1_Silent_p.R111R|ZNF581_uc002qlq.2_5'Flank	NM_207115	NP_996998	Q9UK33	ZN580_HUMAN	zinc finger protein 580	111	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		AGAGCCACCGCGTGTCGCACT	0.692													3	17					0	0	0	0	T	56154207	T	T	56154207	2	4	94	1	0	0	0	0	0	0	0	1	18079	755	27	1		1	ZNF580	19	56154207	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	3881407	56154207	2974776	249	18423											
PDYN	5173	broad.mit.edu	37	chr20	1961196	1961196	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctcctcttggggtatttgcGcaaaaagcccccatagcgtt	8	11	10	12	2	1	0	0	0	1	0	2	0	2	0	3	2	3	4	3	2	4	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:1961196G>A	uc010gaj.2	-	3	780	c.538C>T	c.(538-540)CGC>TGC	p.R180C	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.R180C|PDYN_uc010zpt.1_Missense_Mutation_p.R25C	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	180					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity	p.R180C(1)		upper_aerodigestive_tract(1)|ovary(1)	2						GGGTATTTGCGCAAAAAGCCC	0.602													26	66					0	0	0	0	A	1961196	A	A	1961196	3	1	94	1	0	0	0	0	1	0	0	0	11753	1087	38	1	230	1	PDYN	20	1961196	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		1961196	61064324	250	18424											
TGM6	343641	broad.mit.edu	37	chr20	2375141	2375141	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcagcggtcgaggaatggCgctgcccaccacacccagga	9	4	14	14	3	0	0	0	0	0	0	1	3	0	2	3	5	2	2	3	5	1	0	rs147506152	by1000genomes	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:2375141C>T	uc002wfy.1	+	2	112	c.51C>T	c.(49-51)GGC>GGT	p.G17G	TGM6_uc010gal.1_Silent_p.G17G	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	17					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CGAGGAATGGCGCTGCCCACC	0.647													3	28					0	0	0	0	T	2375141	T	T	2375141	2	4	94	1	0	0	0	0	0	0	0	1	15900	755	27	1		1	TGM6	20	2375141	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	413945	2375141	60650379	251	18425											
PAK7	57144	broad.mit.edu	37	chr20	9547019	9547019	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgaggaccatctgtgctcGatcgtaatccacctgggaag	9	9	12	11	2	1	1	0	1	1	0	4	4	2	3	3	2	1	3	3	2	2	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:9547019G>A	uc002wnl.2	-	6	1548	c.1003C>T	c.(1003-1005)CGA>TGA	p.R335*	PAK7_uc002wnk.2_Nonsense_Mutation_p.R335*|PAK7_uc002wnj.2_Nonsense_Mutation_p.R335*|PAK7_uc010gby.1_Nonsense_Mutation_p.R335*	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	335	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ATCTGTGCTCGATCGTAATCC	0.537													23	90					0	0	0	0	A	9547019	A	A	9547019	4	1	94	1	0	0	0	0	0	1	0	0	11459	1066	37	1	1180	1	PAK7	20	9547019	Nonsense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	7171878	9547019	53478501	252	18426											
NCOA6	23054	broad.mit.edu	37	chr20	33329679	33329679	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggatccgaaggctgcccatCctttttggactgatcttcag	8	12	10	11	1	2	1	1	1	1	0	4	4	4	3	3	3	1	1	3	3	1	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:33329679C>T	uc002xav.2	-	12	6952	c.4381G>A	c.(4381-4383)GAT>AAT	p.D1461N	NCOA6_uc002xaw.2_Missense_Mutation_p.D1461N	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1461					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						GGCTGCCCATCCTTTTTGGAC	0.448													19	67					0	0	0	0	T	33329679	T	T	33329679	3	4	94	1	0	0	0	0	1	0	0	0	10287	855	30	2	1830	2	NCOA6	20	33329679	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	23782660	33329679	29695841	253	18427											
NCOA3	8202	broad.mit.edu	37	chr20	46256365	46256365	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagccatacatttaattgccGtatgttgatgaaaacaccac	15	11	6	9	1	0	2	0	2	0	0	0	2	0	2	3	0	4	2	3	0	6	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:46256365G>A	uc002xtk.2	+	7	798	c.593G>A	c.(592-594)CGT>CAT	p.R198H	NCOA3_uc010ght.1_Missense_Mutation_p.R198H|NCOA3_uc002xtl.2_Missense_Mutation_p.R198H|NCOA3_uc002xtm.2_Missense_Mutation_p.R198H|NCOA3_uc002xtn.2_Missense_Mutation_p.R198H|NCOA3_uc010zyc.1_5'UTR	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	198					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TTTAATTGCCGTATGTTGATG	0.383													24	60					0	0	0	0	A	46256365	A	A	46256365	3	1	94	1	0	0	0	0	1	0	0	0	10284	1145	40	1	611	1	NCOA3	20	46256365	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	12926686	46256365	16769155	254	18428											
ADRM1	11047	broad.mit.edu	37	chr20	60883183	60883183	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatctggggagtcgctgccGcagaccgcggatgagatcca	8	6	14	13	4	1	2	0	1	1	2	3	5	2	4	4	3	1	2	4	3	0	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:60883183G>A	uc002ycn.2	+	8	1043	c.963G>A	c.(961-963)CCG>CCA	p.P321P	ADRM1_uc002yco.2_Silent_p.P321P	NM_007002	NP_008933	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1 precursor	321					proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			AGTCGCTGCCGCAGACCGCGG	0.647													6	17					0	0	0	0	A	60883183	A	A	60883183	2	1	94	1	0	0	0	0	0	0	0	1	345	1074	38	1		1	ADRM1	20	60883183	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	14626818	60883183	2142337	255	18429											
KRTAP15-1	254950	broad.mit.edu	37	chr21	31812666	31812666	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtcttacaactgcagctcTggaaacttctcctcctgctg	8	13	7	13	0	3	0	0	0	3	0	5	1	4	1	2	1	6	3	2	1	3	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr21:31812666T>A	uc002yod.2	+	1	21	c.21T>A	c.(19-21)TCT>TCA	p.S7S		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	7						intermediate filament					0						ACTGCAGCTCTGGAAACTTCT	0.438													14	62					0	0	0	0	A	31812666	A	A	31812666	2	1	94	1	0	0	0	0	0	0	0	1	8565	1567	55	5		5	KRTAP15-1	21	31812666	Silent	SNP	T	TCGA-CQ-5327-01A-01D-1683-08		31812666	16317229	256	18430											
SFRS15	57466	broad.mit.edu	37	chr21	33067131	33067131	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaataaagttttacctgctGatgcggcttctgtgtaagtg	10	14	11	6	1	1	2	0	1	1	1	1	2	1	2	1	1	3	4	1	1	5	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr21:33067131G>A	uc002ypd.2	-	10	1657	c.1231C>T	c.(1231-1233)CAG>TAG	p.Q411*	SFRS15_uc002ype.2_Nonsense_Mutation_p.Q411*|SFRS15_uc010glu.2_Nonsense_Mutation_p.Q396*|SFRS15_uc002ypf.1_Nonsense_Mutation_p.Q85*	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	411						nucleus	nucleotide binding|RNA binding				0						TTTACCTGCTGATGCGGCTTC	0.408													12	40					0	0	0	0	A	33067131	A	A	33067131	4	1	94	1	0	0	0	0	0	1	0	0	14236	1299	45	2	2256	2	SFRS15	21	33067131	Nonsense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	1254465	33067131	15062764	257	18431											
KCNJ15	3772	broad.mit.edu	37	chr21	39671493	39671493	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccggtgagcccatttcaaatCataccccctgcatcatgaaa	12	9	6	14	1	3	2	3	2	0	0	3	2	3	2	4	1	3	1	4	1	3	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr21:39671493C>G	uc002ywv.2	+	4	612	c.310C>G	c.(310-312)CAT>GAT	p.H104D	KCNJ15_uc002yww.2_Missense_Mutation_p.H104D|KCNJ15_uc002ywx.2_Missense_Mutation_p.H104D	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	104	Extracellular (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						CATTTCAAATCATACCCCCTG	0.493													20	73					0	0	0	0	G	39671493	G	G	39671493	3	3	94	1	0	0	0	0	1	0	0	0	8088	826	29	2	312	2	KCNJ15	21	39671493	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	6604362	39671493	8458402	258	18432											
ADRBK2	157	broad.mit.edu	37	chr22	26118286	26118286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtttgtgcagtggaagaaaGagttgaacgaaaccttcaag	15	9	12	5	1	1	3	1	1	0	2	1	5	1	4	1	1	3	3	1	1	5	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:26118286G>A	uc003abx.3	+	21	2083	c.1936G>A	c.(1936-1938)GAG>AAG	p.E646K	ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	646	PH.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	GTGGAAGAAAGAGTTGAACGA	0.552													23	84					0	0	0	0	A	26118286	A	A	26118286	3	1	94	1	0	0	0	0	1	0	0	0	344	943	33	2	2018	2	ADRBK2	22	26118286	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		26118286	25186280	259	18433											
TST	7263	broad.mit.edu	37	chr22	37407206	37407206	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggccacgtggcaggcggtGactcccttgcggcacgtggc	6	6	16	13	4	0	1	0	1	0	0	1	1	1	1	2	6	1	2	2	6	1	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:37407206G>A	uc003aqg.2	-	2	1456	c.756C>T	c.(754-756)GTC>GTT	p.V252V	TST_uc003aqh.2_Silent_p.V252V	NM_003312	NP_003303	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase	252	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity				0						GGCAGGCGGTGACTCCCTTGC	0.642													5	30					0	0	0	0	A	37407206	A	A	37407206	2	1	94	1	0	0	0	0	0	0	0	1	16740	1277	45	2		2	TST	22	37407206	Silent	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	11288920	37407206	13897360	260	18434											
EP300	2033	broad.mit.edu	37	chr22	41547912	41547912	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagcacagaagtgaattctCaggccattgctgagaagcag	13	8	12	8	0	1	3	1	2	1	2	2	4	1	3	1	1	3	4	1	1	4	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:41547912C>T	uc003azl.3	+	15	3288	c.2893C>T	c.(2893-2895)CAG>TAG	p.Q965*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	965					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AGTGAATTCTCAGGCCATTGC	0.478			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				11	84					0	0	0	0	T	41547912	T	T	41547912	4	4	94	1	0	0	0	0	0	1	0	0	5172	827	29	2	2951	2	EP300	22	41547912	Nonsense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	4140706	41547912	9756654	261	18435											
EFCAB6	64800	broad.mit.edu	37	chr22	43924776	43924776	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtcgttgtaggagatttttGaagacagcgtcttatcgtaa	11	14	11	5	3	1	3	0	1	1	2	3	4	1	3	0	1	1	3	0	1	4	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:43924776G>C	uc003bdy.1	-	32	4678	c.4463C>G	c.(4462-4464)TCA>TGA	p.S1488*	EFCAB6_uc003bdz.1_Nonsense_Mutation_p.S1336*|EFCAB6_uc010gzi.1_Nonsense_Mutation_p.S1336*	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1488	Interaction with AR.|Interaction with PARK7.|EF-hand 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				GGAGATTTTTGAAGACAGCGT	0.512													8	91					0	0	0	0	C	43924776	C	C	43924776	4	2	94	1	0	0	0	0	0	1	0	0	4961	1294	45	2	46	2	EFCAB6	22	43924776	Nonsense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	2376864	43924776	7379790	262	18436											
TUBGCP6	85378	broad.mit.edu	37	chr22	50659487	50659487	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atggatgttccaccgtggccGagtgggagccacatctgaca	9	8	13	11	2	1	1	0	1	1	0	2	4	2	3	4	3	1	1	4	3	0	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:50659487G>A	uc003bkb.1	-	16	3813	c.3301C>T	c.(3301-3303)CGG>TGG	p.R1101W	TUBGCP6_uc003bka.1_Missense_Mutation_p.R188W|TUBGCP6_uc010har.1_Missense_Mutation_p.R1093W|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1101	9 X 27 AA tandem repeats.|3.				G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CACCGTGGCCGAGTGGGAGCC	0.597													20	111					0	0	0	0	A	50659487	A	A	50659487	3	1	94	1	0	0	0	0	1	0	0	0	16838	1057	37	1	2198	1	TUBGCP6	22	50659487	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	6734711	50659487	645079	263	18437											
PFKFB1	5207	broad.mit.edu	37	chrX	54971913	54971913	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgatatttatcttggtctcGcagtgcaaattcttcagggt	8	15	10	8	2	4	0	1	0	3	0	5	1	4	0	0	2	1	2	0	2	3	6			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:54971913G>A	uc004dty.1	-	10	1128	c.1057C>T	c.(1057-1059)CGA>TGA	p.R353*	PFKFB1_uc010nkd.1_Nonsense_Mutation_p.R161*|PFKFB1_uc011mol.1_Nonsense_Mutation_p.R288*	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	353	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						TCTTGGTCTCGCAGTGCAAAT	0.473													7	19					0	0	0	0	A	54971913	A	A	54971913	4	1	94	1	0	0	0	0	0	1	0	0	11815	1095	38	1	378	1	PFKFB1	23	54971913	Nonsense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08		54971913	100298647	264	18438											
EFNB1	1947	broad.mit.edu	37	chrX	68058611	68058611	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcctgtagcacagttctcGaccccaacgtgttggtcacc	7	10	9	15	2	2	0	1	0	1	0	3	1	2	0	4	1	3	4	4	1	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:68058611G>A	uc004dxd.3	+	2	1060	c.280G>A	c.(280-282)GAC>AAC	p.D94N	EFNB1_uc004dxe.2_Missense_Mutation_p.D94N	NM_004429	NP_004420	P98172	EFNB1_HUMAN	ephrin-B1 precursor	94	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding				0						CACAGTTCTCGACCCCAACGT	0.567													6	12					0	0	0	0	A	68058611	A	A	68058611	3	1	94	1	0	0	0	0	1	0	0	0	4977	1058	37	1	286	1	EFNB1	23	68058611	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	13086698	68058611	87211949	265	18439											
CYLC1	1538	broad.mit.edu	37	chrX	83127918	83127918	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgacaaaagaaaactagaaGaaggccagaaaccagctcat	21	4	8	8	0	1	5	1	1	0	4	1	5	1	5	2	1	3	1	2	1	8	1			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:83127918G>C	uc004eei.1	+	4	223	c.202G>C	c.(202-204)GAA>CAA	p.E68Q	CYLC1_uc004eeh.1_Missense_Mutation_p.E67Q	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	68					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						AAAACTAGAAGAAGGCCAGAA	0.343													3	19					0	0	0	0	C	83127918	C	C	83127918	3	2	94	1	0	0	0	0	1	0	0	0	4158	943	33	2	216	2	CYLC1	23	83127918	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	15069307	83127918	72142642	266	18440											
LHFPL1	340596	broad.mit.edu	37	chrX	111874751	111874751	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtttcttccagcaaagcaaGagagccaggtgcagatcaac	13	7	11	10	0	2	2	1	0	1	2	3	3	3	2	2	2	5	4	2	2	3	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:111874751G>C	uc004epq.2	-	4	893	c.560C>G	c.(559-561)TCT>TGT	p.S187C	LHFPL1_uc004epp.2_Missense_Mutation_p.S210C|LHFPL1_uc010nqa.2_RNA|LHFPL1_uc010nqb.2_Missense_Mutation_p.S154C	NM_178175	NP_835469	Q86WI0	LHPL1_HUMAN	lipoma HMGIC fusion partner-like 1 precursor	187						integral to membrane					0						AGCAAAGCAAGAGAGCCAGGT	0.512													21	74					0	0	0	0	C	111874751	C	C	111874751	3	2	94	1	0	0	0	0	1	0	0	0	8805	942	33	2	106	2	LHFPL1	23	111874751	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	28746833	111874751	43395809	267	18441											
RHOXF2B	727940	broad.mit.edu	37	chrX	119293055	119293055	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaaggcggagaagaaaaaGatggcggcggagaagaaaaa	19	1	15	6	3	0	5	0	0	0	5	0	7	0	5	1	5	0	0	1	5	7	0			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:119293055G>T	uc004esl.3	+	2	404	c.214G>T	c.(214-216)GAT>TAT	p.D72Y		NM_001099685	NP_001093155	P0C7M4	RHF2B_HUMAN	Rhox homeobox family, member 2B	72						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGAAGAAAAAGATGGCGGCGG	0.592													5	55					0.000151284	0.00015716	1	0	T	119293055	T	T	119293055	3	4	94	1	0	0	0	0	1	0	0	0	13414	942	33	2	1103	2	RHOXF2B	23	119293055	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	7418304	119293055	35977505	268	18442											
ODZ1	10178	broad.mit.edu	37	chrX	123554626	123554626	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	catcaggcgacactgctaagGaggaaggggctttcatcttt	10	10	12	9	1	3	0	2	0	1	0	3	3	3	2	0	5	1	2	0	5	2	3			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:123554626G>C	uc004euj.2	-	24	4560	c.4496C>G	c.(4495-4497)TCC>TGC	p.S1499C	ODZ1_uc011muj.1_Missense_Mutation_p.S1505C|ODZ1_uc010nqy.2_Missense_Mutation_p.S1506C	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1499	Extracellular (Potential).|NHL 5.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CACTGCTAAGGAGGAAGGGGC	0.463													22	61					0	0	0	0	C	123554626	C	C	123554626	3	2	94	1	0	0	0	0	1	0	0	0	10888	1174	41	2	3713	2	ODZ1	23	123554626	Missense_Mutation	SNP	G	TCGA-CQ-5327-01A-01D-1683-08	4261571	123554626	31715934	269	18443											
GPR50	9248	broad.mit.edu	37	chrX	150349840	150349840	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccctactgtagtcactacCagtaccaatgattaccatga	13	10	6	12	0	1	2	1	2	0	0	1	3	1	2	4	0	4	2	4	0	6	5			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:150349840C>G	uc010ntg.1	+	2	1920	c.1785C>G	c.(1783-1785)ACC>ACG	p.T595T		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	595	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TAGTCACTACCAGTACCAATG	0.537													23	157					0	0	0	0	G	150349840	G	G	150349840	2	3	94	1	0	0	0	0	0	0	0	1	6735	581	21	4		4	GPR50	23	150349840	Silent	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	26795214	150349840	4920720	270	18444											
MAGEA10	4109	broad.mit.edu	37	chrX	151303720	151303720	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgggtaaagactcactgtCtggcaggacctgtagggtgc	8	10	14	9	0	3	1	1	0	2	1	3	2	3	2	1	4	1	3	1	4	3	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:151303720C>T	uc004ffk.2	-	5	781	c.373G>A	c.(373-375)GAC>AAC	p.D125N	MAGEA10_uc004ffl.2_Missense_Mutation_p.D125N	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	125											0	Acute lymphoblastic leukemia(192;6.56e-05)					GACTCACTGTCTGGCAGGACC	0.502													47	146					0	0	0	0	T	151303720	T	T	151303720	3	4	94	1	0	0	0	0	1	0	0	0	9215	913	32	2	740	2	MAGEA10	23	151303720	Missense_Mutation	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	953880	151303720	3966840	271	18445											
DNASE1L1	1774	broad.mit.edu	37	chrX	153640369	153640369	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttagggtgggggacgccgCggccccgacctagcgggcga	6	4	18	13	6	0	0	0	0	0	0	0	3	0	1	4	5	1	0	4	5	2	2			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:153640369C>T	uc004fks.1	-						DNASE1L1_uc004fkt.1_5'Flank|DNASE1L1_uc004fku.1_5'UTR|DNASE1L1_uc004fkv.1_5'UTR|DNASE1L1_uc004fkw.1_5'UTR|TAZ_uc004fkx.2_Intron|TAZ_uc004fky.2_Intron|TAZ_uc004fkz.2_Intron|TAZ_uc004fla.2_Intron|TAZ_uc004flb.2_Intron|TAZ_uc010nuy.2_Intron|TAZ_uc004flc.3_Intron	NM_006730	NP_006721	P49184	DNSL1_HUMAN	deoxyribonuclease I-like 1 precursor						DNA catabolic process	endoplasmic reticulum	DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGGACGCCGCGGCCCCGACC	0.701											OREG0003602	type=REGULATORY REGION|Gene=DNASE1L1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	14					0	0	0	0	T	153640369	T	T	153640369	1	4	94	0	1	0	0	0	0	0	0	0	4683	783	27	1		1	DNASE1L1	23	153640369	5'Flank	SNP	C	TCGA-CQ-5327-01A-01D-1683-08	2336649	153640369	1630191	272	18446											
DOCK7	85440	broad.mit.edu	37	chr1	63027310	63027310	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtatggatagacgaaacaGcaacaacttcaacattaaaa	19	8	7	7	1	1	1	1	0	0	1	1	3	1	2	0	1	5	2	0	1	8	4			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr1:63027310G>A	uc001daq.2	-	19	2211	c.2177C>T	c.(2176-2178)GCT>GTT	p.A726V	DOCK7_uc001dan.2_Missense_Mutation_p.A618V|DOCK7_uc001dao.2_Missense_Mutation_p.A618V|DOCK7_uc001dap.2_Missense_Mutation_p.A726V	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	726	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AGACGAAACAGCAACAACTTC	0.289													3	56					0	0	0	0	A	63027310	A	A	63027310	3	1	95	1	0	0	0	0	1	0	0	0	4714	971	34	4	4276	4	DOCK7	1	63027310	Missense_Mutation	SNP	G	TCGA-CQ-5329-01A-01D-1683-08		63027310	186223311	1	18447											
ADCY10	55811	broad.mit.edu	37	chr1	167868860	167868860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgctgatgtggccagcaGccagtcctggcaagaaggca	11	6	13	11	0	0	2	0	1	0	1	1	2	1	2	3	3	3	4	3	3	2	0			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr1:167868860G>A	uc001ger.2	-	6	741	c.443C>T	c.(442-444)GCT>GTT	p.A148V	ADCY10_uc009wvk.2_Missense_Mutation_p.A56V|ADCY10_uc010plj.1_5'UTR|ADCY10_uc009wvl.2_Missense_Mutation_p.A147V|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	148	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						GTGGCCAGCAGCCAGTCCTGG	0.493													9	20					0	0	0	0	A	167868860	A	A	167868860	3	1	95	1	0	0	0	0	1	0	0	0	293	971	34	4	4501	4	ADCY10	1	167868860	Missense_Mutation	SNP	G	TCGA-CQ-5329-01A-01D-1683-08	104841550	167868860	81381761	2	18448											
ZNF512	84450	broad.mit.edu	37	chr2	27822848	27822848	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttatgtcagggaggaagcaaCggcctaaaactcagcccaat	14	7	10	10	1	2	0	2	0	0	0	2	2	2	2	2	3	4	1	2	3	6	2			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr2:27822848C>T	uc002rla.2	+	5	472	c.385C>T	c.(385-387)CGG>TGG	p.R129W	ZNF512_uc010ylv.1_Missense_Mutation_p.R50W|ZNF512_uc010ylw.1_Intron|ZNF512_uc002rlb.2_Missense_Mutation_p.R50W|ZNF512_uc010ylx.1_Missense_Mutation_p.R50W|ZNF512_uc002rlc.2_Missense_Mutation_p.R50W|ZNF512_uc010yly.1_RNA|ZNF512_uc010ylz.1_Intron	NM_032434	NP_115810	Q96ME7	ZN512_HUMAN	zinc finger protein 512	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GAGGAAGCAACGGCCTAAAAC	0.478													15	15					0	0	0	0	T	27822848	T	T	27822848	3	4	95	1	0	0	0	0	1	0	0	0	18023	527	19	1	403	1	ZNF512	2	27822848	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08		27822848	215376525	3	18449											
SATB2	23314	broad.mit.edu	37	chr2	200298060	200298060	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agaggggagaggcattaataCcttgggcctgggccgcagag	10	6	17	8	1	0	3	0	0	0	3	0	4	0	3	3	5	1	2	3	5	2	3			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr2:200298060C>A	uc002uuy.1	-	3	1163	c.346_splice	c.e3+1	p.G116_splice	SATB2_uc010fsq.1_Splice_Site_p.V116_splice|SATB2_uc002uuz.1_Splice_Site_p.G116_splice|SATB2_uc002uva.1_Splice_Site_p.G116_splice	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2							cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCATTAATACCTTGGGCCTG	0.498													12	27					0.00136819	0.00167915	1	0	A	200298060	A	A	200298060	5	1	95	1	0	0	0	0	0	0	1	0	13919	521	18	4	1890	4	SATB2	2	200298060	Splice_Site	SNP	C	TCGA-CQ-5329-01A-01D-1683-08	172475212	200298060	42901313	4	18450											
KIAA1486	57624	broad.mit.edu	37	chr2	226447697	226447697	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcctcttctcctccggcCgcagcctgctgcgcaagtcg	4	8	10	19	4	2	0	0	0	2	0	5	0	3	0	6	1	4	3	6	1	1	1			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr2:226447697C>T	uc002voe.2	+	4	1739	c.1564C>T	c.(1564-1566)CGC>TGC	p.R522C	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.R292C	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	522										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		CTCCTCCGGCCGCAGCCTGCT	0.701													6	10					0	0	0	0	T	226447697	T	T	226447697	3	4	95	1	0	0	0	0	1	0	0	0	8276	652	23	1	1574	1	KIAA1486	2	226447697	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08	26149637	226447697	16751676	5	18451											
MAGEF1	64110	broad.mit.edu	37	chr3	184428979	184428983	+	Frame_Shift_Del	DEL	TCGGA	-	-																															atcttccataataagcctctTcggatacccaaagaggaaat																										TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr3:184428979_184428983delTCGGA	uc003fpa.2	-	1	854_858	c.627_631delTCCGA	c.(625-633)TATCCGAAGfs	p.Y209fs		NM_022149	NP_071432	Q9HAY2	MAGF1_HUMAN	melanoma antigen family F, 1	209_211	MAGE.									ovary(1)	1	all_cancers(143;4.61e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;5.64e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.56e-22)			ATAAGCCTCTTCGGATACCCAAAGA	0.507													---	---	---								-	184428983	-	-	184428979	7	5	95	1	0	1	0	1	0	0	0	0	9240	1792	62	0	296	0	MAGEF1	3	184428979	Frame_Shift_Del	DEL	TCGGA	TCGA-CQ-5329-01A-01D-1683-08		184428979	13593451	6	18452											
PDHA2	5161	broad.mit.edu	37	chr4	96761394	96761394	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccgtaactcctcaaatgaCgctacatttgaaattaagaa	15	11	5	10	2	1	3	1	2	0	1	3	3	3	3	2	0	2	2	2	0	6	4	rs143281239		TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr4:96761394C>T	uc003htr.3	+	1	156	c.93C>T	c.(91-93)GAC>GAT	p.D31D		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	31					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CCTCAAATGACGCTACATTTG	0.502													4	21					0	0	0	0	T	96761394	T	T	96761394	2	4	95	1	0	0	0	0	0	0	0	1	11719	535	19	1		1	PDHA2	4	96761394	Silent	SNP	C	TCGA-CQ-5329-01A-01D-1683-08		96761394	94392882	7	18453											
PCDHGA5	56110	broad.mit.edu	37	chr5	140745185	140745185	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgtcatggaccatggaaccCcgcccctctctacagaaagc	10	6	8	17	2	2	1	1	0	1	1	3	3	2	3	6	2	3	0	6	2	3	1			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr5:140745185C>A	uc003lju.1	+	1	1288	c.1288C>A	c.(1288-1290)CCG>ACG	p.P430T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.P430T	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	430	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATGGAACCCCGCCCCTCTC	0.458													25	62					6.32553e-13	8.75843e-13	1	0	A	140745185	A	A	140745185	3	1	95	1	0	0	0	0	1	0	0	0	11611	623	22	4	1290	4	PCDHGA5	5	140745185	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08		140745185	40170075	8	18454											
KCNK17	89822	broad.mit.edu	37	chr6	39271892	39271892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagagcccgccagccaccGcgccttgtcaggatcctgtg	6	6	12	17	3	1	1	1	0	0	1	2	2	2	2	7	1	2	0	7	1	0	1			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr6:39271892G>A	uc003ooo.2	-	4	669	c.529C>T	c.(529-531)CGG>TGG	p.R177W	KCNK17_uc003oop.2_Missense_Mutation_p.R177W	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	177	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						GCCAGCCACCGCGCCTTGTCA	0.672													8	32					0	0	0	0	A	39271892	A	A	39271892	3	1	95	1	0	0	0	0	1	0	0	0	8103	1086	38	1	609	1	KCNK17	6	39271892	Missense_Mutation	SNP	G	TCGA-CQ-5329-01A-01D-1683-08		39271892	131843175	9	18455											
TJAP1	93643	broad.mit.edu	37	chr6	43471425	43471425	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgcaacaagtcccacttccGaaaccacaagtttgccgatg	12	8	8	13	2	0	0	0	0	0	0	2	2	2	0	4	0	4	2	4	0	4	2			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr6:43471425G>A	uc003ovd.2	+	10	936	c.560G>A	c.(559-561)CGA>CAA	p.R187Q	TJAP1_uc003ovf.2_Missense_Mutation_p.R177Q|TJAP1_uc003ove.2_Missense_Mutation_p.R177Q|TJAP1_uc003ovc.2_Missense_Mutation_p.R177Q|TJAP1_uc010jyp.2_Missense_Mutation_p.R146Q|TJAP1_uc011dvh.1_Missense_Mutation_p.R177Q|TJAP1_uc003ovg.2_Missense_Mutation_p.R53Q|TJAP1_uc011dvi.1_Missense_Mutation_p.R187Q|TJAP1_uc011dvj.1_5'UTR|TJAP1_uc003ovi.2_Missense_Mutation_p.R53Q	NM_001146016	NP_001139488	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 isoform a	187						Golgi apparatus|tight junction	protein binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TCCCACTTCCGAAACCACAAG	0.562													8	36					0	0	0	0	A	43471425	A	A	43471425	3	1	95	1	0	0	0	0	1	0	0	0	15994	1058	37	1	586	1	TJAP1	6	43471425	Missense_Mutation	SNP	G	TCGA-CQ-5329-01A-01D-1683-08	4199533	43471425	127643642	10	18456											
FILIP1	27145	broad.mit.edu	37	chr6	76023395	76023395	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtacttcggcttttaagtctCgacttttagcttcttccaac	7	17	6	11	2	2	0	0	0	2	0	5	1	3	0	1	1	3	3	1	1	4	8			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr6:76023395C>T	uc003pia.2	-	5	2526	c.2153G>A	c.(2152-2154)CGA>CAA	p.R718Q	FILIP1_uc003phy.1_Missense_Mutation_p.R718Q|FILIP1_uc003phz.2_Missense_Mutation_p.R619Q|FILIP1_uc010kbe.2_Missense_Mutation_p.R721Q|FILIP1_uc003pib.1_Missense_Mutation_p.R470Q	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	718	Potential.									skin(3)|ovary(1)	4						TTTTAAGTCTCGACTTTTAGC	0.403													36	77					0	0	0	0	T	76023395	T	T	76023395	3	4	95	1	0	0	0	0	1	0	0	0	5926	884	31	1	1496	1	FILIP1	6	76023395	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08	32551970	76023395	95091672	11	18457											
FNDC1	84624	broad.mit.edu	37	chr6	159653380	159653380	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcagccccgcccaggggcGcccccctcggcttcggcctc	3	4	12	22	5	0	0	0	0	0	0	3	0	0	0	7	4	1	2	7	4	0	1			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr6:159653380G>A	uc010kjv.2	+	11	2036	c.1836G>A	c.(1834-1836)GCG>GCA	p.A612A	FNDC1_uc010kjw.1_Silent_p.A497A	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	612						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCCCAGGGGCGCCCCCCTCGG	0.687													11	28					0	0	0	0	A	159653380	A	A	159653380	2	1	95	1	0	0	0	0	0	0	0	1	6000	1074	38	1		1	FNDC1	6	159653380	Silent	SNP	G	TCGA-CQ-5329-01A-01D-1683-08	83629985	159653380	11461687	12	18458											
PION	54103	broad.mit.edu	37	chr7	76984647	76984647	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aataaagacgactggctgagCagtgctctatagagctttcc	12	10	10	9	1	1	3	0	1	1	2	2	4	2	3	1	1	3	4	1	1	5	4			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr7:76984647C>A	uc003ugf.2	-	16	1300	c.1221G>T	c.(1219-1221)CTG>CTT	p.L407L	PION_uc003ugg.1_Silent_p.L192L	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	407					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						ACTGGCTGAGCAGTGCTCTAT	0.473													21	70					3.10358e-05	3.89752e-05	1	0	A	76984647	A	A	76984647	2	1	95	1	0	0	0	0	0	0	0	1	11989	697	25	4		4	PION	7	76984647	Silent	SNP	C	TCGA-CQ-5329-01A-01D-1683-08		76984647	82154016	13	18459											
PRSS1	5644	broad.mit.edu	37	chr7	142459656	142459656	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagactgggagagcacaacAtcgaagtcctggaggggaat	13	6	15	7	1	0	2	0	1	0	2	2	7	1	4	1	4	2	1	1	4	3	0			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr7:142459656A>G	uc003wak.2	+	3	249	c.232A>G	c.(232-234)ATC>GTC	p.I78V	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.I18V	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	78	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			AGAGCACAACATCGAAGTCCT	0.552									Hereditary_Pancreatitis				7	132					0	0	0	0	G	142459656	G	G	142459656	3	3	95	1	0	0	0	0	1	0	0	0	12676	217	8	5	242	5	PRSS1	7	142459656	Missense_Mutation	SNP	A	TCGA-CQ-5329-01A-01D-1683-08	65475009	142459656	16679007	14	18460											
FRMD3	257019	broad.mit.edu	37	chr9	85950554	85950554	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatcgtaatcaccaagctcaGctgtaatgagtgaaaaaata	17	9	8	7	1	2	2	2	2	0	0	3	3	2	2	1	0	2	4	1	0	7	3			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr9:85950554G>A	uc004ams.1	-	6	675	c.473C>T	c.(472-474)GCT>GTT	p.A158V	FRMD3_uc004amr.1_Missense_Mutation_p.A144V	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	158	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						ACCAAGCTCAGCTGTAATGAG	0.413													10	23					0	0	0	0	A	85950554	A	A	85950554	3	1	95	1	0	0	0	0	1	0	0	0	6084	985	34	4	1356	4	FRMD3	9	85950554	Missense_Mutation	SNP	G	TCGA-CQ-5329-01A-01D-1683-08		85950554	55262877	15	18461											
LPPR1	54886	broad.mit.edu	37	chr9	104048520	104048520	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatcataagattcacaggTgagtacaagatggtgctgaa	15	9	12	5	0	2	4	2	2	0	2	2	5	2	5	0	3	2	2	0	3	4	3			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr9:104048520T>A	uc004bbb.2	+	4	784	c.385_splice	c.e4+2	p.G129_splice	LPPR1_uc011lvi.1_Splice_Site_p.G105_splice|LPPR1_uc004bbc.2_Splice_Site_p.G129_splice|LPPR1_uc010mtc.2_Splice_Site_p.G113_splice	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3							integral to membrane	catalytic activity				0						GATTCACAGGTGAGTACAAGA	0.373													13	38					0	0	0	0	A	104048520	A	A	104048520	5	1	95	1	0	0	0	0	0	0	1	0	8974	1710	59	5	397	5	LPPR1	9	104048520	Splice_Site	SNP	T	TCGA-CQ-5329-01A-01D-1683-08	18097966	104048520	37164911	16	18462											
NOTCH1	4851	broad.mit.edu	37	chr9	139393579	139393579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacccaggtcatctacggCgttgacgtcggcgtgtgagt	6	10	13	12	5	3	2	2	2	1	0	4	2	3	2	1	3	1	1	1	3	1	2			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr9:139393579C>T	uc004chz.2	-	32	6067	c.6067G>A	c.(6067-6069)GCC>ACC	p.A2023T		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2023	ANK 3.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TCATCTACGGCGTTGACGTCG	0.682			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			44	33					0	0	0	0	T	139393579	T	T	139393579	3	4	95	1	0	0	0	0	1	0	0	0	10601	768	27	1	1612	1	NOTCH1	9	139393579	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08	35345059	139393579	1819852	17	18463											
ADAM12	8038	broad.mit.edu	37	chr10	127724762	127724762	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcaggggtctggcagggaCgctaggtgcacgtggagccc	6	6	19	10	2	1	0	0	0	1	0	1	2	1	2	1	7	2	4	1	7	1	1			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr10:127724762C>T	uc001ljk.2	-	21	2904	c.2491G>A	c.(2491-2493)GTC>ATC	p.V831I	ADAM12_uc010qul.1_Missense_Mutation_p.V782I	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	831	SH3-binding; class II (By similarity).|Cytoplasmic (Potential).				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CTGGCAGGGACGCTAGGTGCA	0.522													4	43					0	0	0	0	T	127724762	T	T	127724762	3	4	95	1	0	0	0	0	1	0	0	0	236	536	19	1	250	1	ADAM12	10	127724762	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08		127724762	7809985	18	18464											
OR52N1	79473	broad.mit.edu	37	chr11	5809766	5809766	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgaggcaggctttaaaatcaAtctccttgagattaaaccac	14	10	7	10	1	2	1	1	1	1	1	3	3	2	1	2	2	1	2	2	2	5	4			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr11:5809766A>G	uc010qzo.1	-	1	281	c.281T>C	c.(280-282)ATT>ACT	p.I94T	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		TTTAAAATCAATCTCCTTGAG	0.502													24	95					0	0	0	0	G	5809766	G	G	5809766	3	3	95	1	0	0	0	0	1	0	0	0	11181	101	4	5	684	5	OR52N1	11	5809766	Missense_Mutation	SNP	A	TCGA-CQ-5329-01A-01D-1683-08		5809766	129196750	19	18465											
MICAL2	9645	broad.mit.edu	37	chr11	12278373	12278373	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccccttaacctgggaggcagCgacacgtgttacttctgtaa	9	10	10	12	2	1	0	0	0	1	0	1	2	1	1	3	2	3	3	3	2	3	4			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr11:12278373C>T	uc001mjz.2	+	24	3285	c.2997C>T	c.(2995-2997)AGC>AGT	p.S999S	MICAL2_uc010rch.1_Silent_p.S809S|MICAL2_uc001mka.2_Silent_p.S999S|MICAL2_uc010rci.1_Silent_p.S978S|MICAL2_uc001mkb.2_Silent_p.S773S|MICAL2_uc001mkc.2_Silent_p.S752S|MICAL2_uc001mkd.2_Silent_p.S581S|MICAL2_uc010rcj.1_Silent_p.S211S|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	999						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TGGGAGGCAGCGACACGTGTT	0.537													11	43					0	0	0	0	T	12278373	T	T	12278373	2	4	95	1	0	0	0	0	0	0	0	1	9623	767	27	1		1	MICAL2	11	12278373	Silent	SNP	C	TCGA-CQ-5329-01A-01D-1683-08	6468607	12278373	122728143	20	18466											
KCNA4	3739	broad.mit.edu	37	chr11	30032556	30032556	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taaagttagagacaatcactGgcactggcaaagcaatggtt	15	9	10	7	0	1	1	1	0	0	1	1	2	1	1	0	3	1	5	0	3	6	3			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr11:30032556G>A	uc001msk.2	-	2	2822	c.1670C>T	c.(1669-1671)CCA>CTA	p.P557L		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	557	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GACAATCACTGGCACTGGCAA	0.498													25	25					0	0	0	0	A	30032556	A	A	30032556	3	1	95	1	0	0	0	0	1	0	0	0	8044	1348	47	4	295	4	KCNA4	11	30032556	Missense_Mutation	SNP	G	TCGA-CQ-5329-01A-01D-1683-08	17754183	30032556	104973960	21	18467											
SIDT2	51092	broad.mit.edu	37	chr11	117054508	117054508	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgcagcgcaaagacttccCcagcaacagcttttatgtgg	10	9	9	13	1	0	1	0	0	0	1	1	1	1	1	3	1	5	4	3	1	3	3			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr11:117054508C>T	uc001pqh.1	+	7	757	c.716C>T	c.(715-717)CCC>CTC	p.P239L	SIDT2_uc010rxe.1_Missense_Mutation_p.P239L|SIDT2_uc001pqg.2_Missense_Mutation_p.P239L|SIDT2_uc001pqi.1_Missense_Mutation_p.P239L	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	239	Extracellular (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		AAAGACTTCCCCAGCAACAGC	0.403													12	37					0	0	0	0	T	117054508	T	T	117054508	3	4	95	1	0	0	0	0	1	0	0	0	14368	623	22	4	742	4	SIDT2	11	117054508	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08	87021952	117054508	17952008	22	18468											
SORL1	6653	broad.mit.edu	37	chr11	121445040	121445050	+	Frame_Shift_Del	DEL	ACTGTGGAGAC	-	-																															taaatgtgaccttgaggatgActgtggagacaacagtgatg																										TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr11:121445040_121445050delACTGTGGAGAC	uc001pxx.2	+	24	3508_3518	c.3428_3438delACTGTGGAGAC	c.(3427-3438)GACTGTGGAGACfs	p.D1143fs	SORL1_uc010rzp.1_5'Flank	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1143_1146	Extracellular (Potential).|LDL-receptor class A 2.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CTTGAGGATGACTGTGGAGACAACAGTGATG	0.512													---	---	---								-	121445050	-	-	121445040	7	5	95	1	0	1	0	1	0	0	0	0	14998	275	10	0	3522	0	SORL1	11	121445040	Frame_Shift_Del	DEL	ACTGTGGAGAC	TCGA-CQ-5329-01A-01D-1683-08	4390532	121445040	13561476	23	18469											
KRT85	3891	broad.mit.edu	37	chr12	52758101	52758101	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcccctcaccttctttagaaCgacaaactcattctctgctg	9	12	5	15	1	4	1	2	0	2	1	5	2	4	1	3	0	3	1	3	0	3	4	rs141072357	byFrequency	TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr12:52758101C>T	uc001sag.2	-	3	799	c.679G>A	c.(679-681)GTT>ATT	p.V227I		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	227	Rod.|Coil 1B.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TTCTTTAGAACGACAAACTCA	0.572													14	44					0	0	0	0	T	52758101	T	T	52758101	3	4	95	1	0	0	0	0	1	0	0	0	8538	536	19	1	872	1	KRT85	12	52758101	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08		52758101	81093794	24	18470											
KRT77	374454	broad.mit.edu	37	chr12	53097339	53097340	+	5'Flank	DEL	AC	-	-																															ggctccggctctatatatatAcacacacacacacattactg																										TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr12:53097339_53097340delAC	uc001saw.2	-						KRT77_uc009zmi.2_5'Flank	NM_175078	NP_778253	Q7Z794	K2C1B_HUMAN	keratin 77							keratin filament	structural molecule activity			ovary(1)	1						CTATATATATACACACACACAC	0.47													---	---	---								-	53097340	-	-	53097339	6	5	95	0	1	1	0	1	0	0	0	0	8529	406	14	0		0	KRT77	12	53097339	5'Flank	DEL	AC	TCGA-CQ-5329-01A-01D-1683-08	339238	53097339	80754556	25	18471											
CCDC38	120935	broad.mit.edu	37	chr12	96288808	96288808	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatatttgctttactttttGatgcctgtgctctttttagt	5	23	7	6	0	1	2	0	2	1	0	1	2	1	2	1	0	4	2	1	0	3	9			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr12:96288808G>T	uc001tek.1	-	8	965	c.731C>A	c.(730-732)TCA>TAA	p.S244*		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	244										skin(1)	1						TTTACTTTTTGATGCCTGTGC	0.343													46	82					1.61004e-24	2.28795e-24	1	0	T	96288808	T	T	96288808	4	4	95	1	0	0	0	0	0	1	0	0	2823	1294	45	2	996	2	CCDC38	12	96288808	Nonsense_Mutation	SNP	G	TCGA-CQ-5329-01A-01D-1683-08	43191469	96288808	37563087	26	18472											
NALCN	259232	broad.mit.edu	37	chr13	101759893	101759893	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttctgaacctgtgttctcGcccgacaatgaacagtggct	8	12	10	11	2	2	2	0	2	2	0	3	3	2	2	2	1	2	3	2	1	3	2			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr13:101759893G>A	uc001vox.1	-	22	2713	c.2524C>T	c.(2524-2526)CGA>TGA	p.R842*		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	842	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTGTGTTCTCGCCCGACAATG	0.498													15	35					0	0	0	0	A	101759893	A	A	101759893	4	1	95	1	0	0	0	0	0	1	0	0	10201	1095	38	1	2784	1	NALCN	13	101759893	Nonsense_Mutation	SNP	G	TCGA-CQ-5329-01A-01D-1683-08		101759893	13409985	27	18473											
OR4K15	81127	broad.mit.edu	37	chr14	20444186	20444186	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtatgtgttgtgctcgtccTcatttcatggtttgtgggct	3	19	12	7	1	2	0	2	0	0	0	4	0	3	0	1	2	1	5	1	2	1	4			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr14:20444186T>C	uc010tkx.1	+	1	509	c.509T>C	c.(508-510)CTC>CCC	p.L170P		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	170	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGCTCGTCCTCATTTCATGG	0.448													3	93					0	0	0	0	C	20444186	C	C	20444186	3	2	95	1	0	0	0	0	1	0	0	0	11124	1551	54	5	511	5	OR4K15	14	20444186	Missense_Mutation	SNP	T	TCGA-CQ-5329-01A-01D-1683-08		20444186	86905354	28	18474											
ITFG3	83986	broad.mit.edu	37	chr16	312195	312195	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccttcacgtcaccaggaCaggtgcccactacatcctct	8	9	6	18	1	3	0	2	0	1	0	5	1	5	1	5	2	2	0	5	2	1	2			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr16:312195C>A	uc002cgf.2	+	7	1007	c.812C>A	c.(811-813)ACA>AAA	p.T271K	ITFG3_uc010bqr.2_RNA|ITFG3_uc002cgg.2_Missense_Mutation_p.T271K|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.T271K	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	271	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				GTCACCAGGACAGGTGCCCAC	0.622													3	26					1.024e-07	1.31657e-07	1	0	A	312195	A	A	312195	3	1	95	1	0	0	0	0	1	0	0	0	7910	478	17	4	830	4	ITFG3	16	312195	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08		312195	90042558	29	18475											
SERPINF1	5176	broad.mit.edu	37	chr17	1675210	1675210	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggcacctctggaaaagtcaTatgggaccaggcccagagtc	11	7	12	11	0	2	1	1	0	1	1	3	3	2	3	3	4	0	1	3	4	3	1			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr17:1675210T>C	uc002ftl.2	+	5	641	c.484T>C	c.(484-486)TAT>CAT	p.Y162H	SERPINF1_uc010cjw.2_5'UTR	NM_002615	NP_002606	P36955	PEDF_HUMAN	serine (or cysteine) proteinase inhibitor, clade	162					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			ovary(1)	1						GGAAAAGTCATATGGGACCAG	0.567													7	33					0	0	0	0	C	1675210	C	C	1675210	3	2	95	1	0	0	0	0	1	0	0	0	14179	1406	49	5	498	5	SERPINF1	17	1675210	Missense_Mutation	SNP	T	TCGA-CQ-5329-01A-01D-1683-08		1675210	79520000	30	18476											
OR3A2	4995	broad.mit.edu	37	chr17	3181737	3181737	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccacagtgtgggtcagtgCgttggtgaaggcacaagcca	9	7	16	9	1	1	1	1	1	0	0	1	1	1	1	2	4	2	2	2	4	2	1			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr17:3181737C>T	uc002fvg.2	-	1	532	c.493G>A	c.(493-495)GCA>ACA	p.A165T		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	165	Helical; Name=4; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						TGGGTCAGTGCGTTGGTGAAG	0.582													21	89					0	0	0	0	T	3181737	T	T	3181737	3	4	95	1	0	0	0	0	1	0	0	0	11092	768	27	1	476	1	OR3A2	17	3181737	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08	1506527	3181737	78013473	31	18477											
ATP2A3	489	broad.mit.edu	37	chr17	3850835	3850835	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccagtgccaggcatgtagtGatgacagccgggaggccctc	8	6	14	13	1	0	2	0	2	0	0	1	3	0	3	4	3	2	2	4	3	1	1			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr17:3850835G>A	uc002fxb.1	-	8	1096	c.945C>T	c.(943-945)ATC>ATT	p.I315I	ATP2A3_uc002fwx.1_Silent_p.I315I|ATP2A3_uc002fwy.1_Silent_p.I315I|ATP2A3_uc002fwz.1_Silent_p.I315I|ATP2A3_uc002fxa.1_Silent_p.I315I|ATP2A3_uc002fxc.1_Silent_p.I315I|ATP2A3_uc002fxd.1_Silent_p.I315I	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	315	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GGCATGTAGTGATGACAGCCG	0.682													53	28					0	0	0	0	A	3850835	A	A	3850835	2	1	95	1	0	0	0	0	0	0	0	1	1140	1280	45	2		2	ATP2A3	17	3850835	Silent	SNP	G	TCGA-CQ-5329-01A-01D-1683-08	669098	3850835	77344375	32	18478											
DVL2	1856	broad.mit.edu	37	chr17	7132326	7132326	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctcagcacccgcacagcGtcatcgttgctcatgttctc	6	11	7	17	3	4	0	3	0	1	0	7	0	5	0	2	0	3	5	2	0	0	2	rs141544993		TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr17:7132326G>A	uc002gez.1	-	9	1278	c.996C>T	c.(994-996)GAC>GAT	p.D332D	DVL2_uc010vtr.1_Silent_p.D326D	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	332	PDZ.				canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						CCCGCACAGCGTCATCGTTGC	0.547													46	21					0	0	0	0	A	7132326	A	A	7132326	2	1	95	1	0	0	0	0	0	0	0	1	4858	1136	40	1		1	DVL2	17	7132326	Silent	SNP	G	TCGA-CQ-5329-01A-01D-1683-08	3281491	7132326	74062884	33	18479											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	12	6	8	15	2	1	0	1	0	0	0	3	1	3	1	3	2	2	4	3	2	2	1	rs28934576	by1000genomes	TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	16					0	0	0	0	T	7577120	T	T	7577120	3	4	95	1	0	0	0	0	1	0	0	0	16448	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08	444794	7577120	73618090	34	18480											
GUCY2D	3000	broad.mit.edu	37	chr17	7910382	7910382	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcactgtcccttcaggactGgagccgggcctcgtctttct	4	12	11	14	2	4	0	2	0	2	0	6	2	5	2	3	3	1	0	3	3	0	2			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr17:7910382G>A	uc002gjt.2	+	5	1457	c.1383G>A	c.(1381-1383)CTG>CTA	p.L461L		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	461	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				CTTCAGGACTGGAGCCGGGCC	0.602													14	59					0	0	0	0	A	7910382	A	A	7910382	2	1	95	1	0	0	0	0	0	0	0	1	6936	1335	47	4		4	GUCY2D	17	7910382	Silent	SNP	G	TCGA-CQ-5329-01A-01D-1683-08	333262	7910382	73284828	35	18481											
DCC	1630	broad.mit.edu	37	chr18	50832067	50832067	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggaaacactggagccaaaCaacctctggtacctattcac	14	8	7	12	0	2	0	1	0	1	0	2	2	2	2	3	3	5	1	3	3	5	3			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr18:50832067C>A	uc002lfe.1	+	13	2618	c.2031C>A	c.(2029-2031)AAC>AAA	p.N677K	DCC_uc010xdr.1_Missense_Mutation_p.N525K|DCC_uc010dpf.1_Missense_Mutation_p.N332K	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	677	Extracellular (Potential).|Fibronectin type-III 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGGAGCCAAACAACCTCTGGT	0.423													15	49					9.16793e-09	1.20748e-08	1	0	A	50832067	A	A	50832067	3	1	95	1	0	0	0	0	1	0	0	0	4299	477	17	4	2081	4	DCC	18	50832067	Missense_Mutation	SNP	C	TCGA-CQ-5329-01A-01D-1683-08		50832067	27245181	36	18482											
EMR1	2015	broad.mit.edu	37	chr19	6908712	6908712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggacgcaggtctccttttgtGcacaaataaataacatcttc	12	12	7	10	1	2	0	0	0	2	0	4	1	2	1	1	2	2	2	1	2	4	5			TCGA-CQ-5329-01A-01D-1683-08	TCGA-CQ-5329-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa9b6fc-4169-4346-98fb-4c711d08d701	fc065f6a-8d73-4f13-9be4-076b7b6ffe71	g.chr19:6908712G>A	uc002mfw.2	+	10	1089	c.1051G>A	c.(1051-1053)GCA>ACA	p.A351T	EMR1_uc010dvc.2_Missense_Mutation_p.A351T|EMR1_uc010dvb.2_Missense_Mutation_p.A299T|EMR1_uc010xji.1_Missense_Mutation_p.A210T|EMR1_uc010xjj.1_Missense_Mutation_p.A174T	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	351	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					CTCCTTTTGTGCACAAATAAA	0.368													15	42					0	0	0	0	A	6908712	A	A	6908712	3	1	95	1	0	0	0	0	1	0	0	0	5128	1319	46	4	1089	4	EMR1	19	6908712	Missense_Mutation	SNP	G	TCGA-CQ-5329-01A-01D-1683-08		6908712	52220271	37	18483											
CACHD1	57685	broad.mit.edu	37	chr1	65047921	65047921	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agttgtagaagcatcctataCggctcacctaacctctcccc	10	10	6	15	1	2	1	1	0	1	1	4	1	3	1	5	1	3	4	5	1	5	5			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:65047921C>T	uc001dbo.1	+	3	296	c.191C>T	c.(190-192)ACG>ATG	p.T64M	CACHD1_uc001dbp.1_Translation_Start_Site|CACHD1_uc001dbq.1_Translation_Start_Site	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	115	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						GCATCCTATACGGCTCACCTA	0.428													29	70					0	0	0	0	T	65047921	T	T	65047921	3	4	96	1	0	0	0	0	1	0	0	0	2549	536	19	1	201	1	CACHD1	1	65047921	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08		65047921	184202700	1	18484											
AHCYL1	10768	broad.mit.edu	37	chr1	110563392	110563392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcatctgccatcatttgatgCccaccttacagagctgacag	10	10	8	13	0	2	3	1	2	1	1	2	3	2	3	3	0	4	2	3	0	1	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:110563392C>T	uc001dyx.2	+	16	1872	c.1505C>T	c.(1504-1506)GCC>GTC	p.A502V	AHCYL1_uc010ovw.1_Missense_Mutation_p.A455V|AHCYL1_uc001dyy.2_Missense_Mutation_p.A455V|AHCYL1_uc010ovx.1_Missense_Mutation_p.A455V	NM_006621	NP_006612	O43865	SAHH2_HUMAN	S-adenosylhomocysteine hydrolase-like 1	502					one-carbon metabolic process	endoplasmic reticulum	adenosylhomocysteinase activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0259)|Colorectal(144;0.123)|all cancers(265;0.134)|Epithelial(280;0.141)|LUSC - Lung squamous cell carcinoma(189;0.143)		TCATTTGATGCCCACCTTACA	0.433													4	153					0	0	0	0	T	110563392	T	T	110563392	3	4	96	1	0	0	0	0	1	0	0	0	410	739	26	4	1567	4	AHCYL1	1	110563392	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	45515471	110563392	138687229	2	18485											
SPAG17	200162	broad.mit.edu	37	chr1	118629569	118629569	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgattctgtggtctagcccGtctgctctgggggatggctc	3	12	15	11	2	4	0	0	0	4	0	5	2	4	1	1	4	2	2	1	4	1	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:118629569G>A	uc001ehk.2	-	11	1490	c.1422C>T	c.(1420-1422)GAC>GAT	p.D474D		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	474						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GGTCTAGCCCGTCTGCTCTGG	0.517													28	59					0	0	0	0	A	118629569	A	A	118629569	2	1	96	1	0	0	0	0	0	0	0	1	15045	1136	40	1		1	SPAG17	1	118629569	Silent	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	8066177	118629569	130621052	3	18486											
ADAMTS4	9507	broad.mit.edu	37	chr1	161160954	161160954	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcccgcccaggggcgccGccgaaggatctccagaatct	7	5	12	17	4	2	1	0	0	2	1	3	3	2	2	6	3	1	0	6	3	2	0	rs114728887	by1000genomes	TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:161160954G>A	uc001fyt.3	-	9	2916	c.2488C>T	c.(2488-2490)CGG>TGG	p.R830W		NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	830	Spacer.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CAGGGGCGCCGCCGAAGGATC	0.637													11	26					0	0	0	0	A	161160954	A	A	161160954	3	1	96	1	0	0	0	0	1	0	0	0	268	1086	38	1	29	1	ADAMTS4	1	161160954	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	42531385	161160954	88089667	4	18487											
TNR	7143	broad.mit.edu	37	chr1	175375720	175375720	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctccctcctcctccactGactgtctctggaccctttct	3	14	5	19	0	2	1	0	1	2	0	7	2	6	2	6	1	1	0	6	1	0	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:175375720G>A	uc001gkp.1	-	1	212	c.131C>T	c.(130-132)TCA>TTA	p.S44L	TNR_uc009wwu.1_Missense_Mutation_p.S44L|TNR_uc010pmz.1_Missense_Mutation_p.S44L	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	44					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CTCCTCCACTGACTGTCTCTG	0.517													19	115					0	0	0	0	A	175375720	A	A	175375720	3	1	96	1	0	0	0	0	1	0	0	0	16404	1294	45	2	4029	2	TNR	1	175375720	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	14214766	175375720	73874901	5	18488											
ACTA1	58	broad.mit.edu	37	chr1	229568748	229568748	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgacctggtgtcgggggcGgcccacgatggacgggaaca	7	5	17	12	4	0	1	0	1	0	0	1	4	0	3	3	6	1	0	3	6	1	0			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:229568748G>A	uc001htm.2	-	2	220	c.115C>T	c.(115-117)CGC>TGC	p.R39C		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	39					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	TGTCGGGGGCGGCCCACGATG	0.726													5	33					0	0	0	0	A	229568748	A	A	229568748	3	1	96	1	0	0	0	0	1	0	0	0	191	1116	39	1	1042	1	ACTA1	1	229568748	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	54193028	229568748	19681873	6	18489											
CKAP2L	150468	broad.mit.edu	37	chr2	113514030	113514030	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtctttcatattgactcctAttaacctttatatctttgat	9	20	4	8	0	3	2	1	2	2	0	4	2	4	2	2	1	1	0	2	1	5	9			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr2:113514030A>G	uc002tie.2	-	4	997	c.918T>C	c.(916-918)AAT>AAC	p.N306N	CKAP2L_uc002tif.2_Intron|CKAP2L_uc010yxp.1_Silent_p.N141N|CKAP2L_uc010yxq.1_Silent_p.N141N	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	306						centrosome					0						ATTGACTCCTATTAACCTTTA	0.408													22	72					0	0	0	0	G	113514030	G	G	113514030	2	3	96	1	0	0	0	0	0	0	0	1	3458	446	16	5		5	CKAP2L	2	113514030	Silent	SNP	A	TCGA-CQ-5330-01A-01D-1683-08		113514030	129685343	7	18490											
OBSL1	23363	broad.mit.edu	37	chr2	220422717	220422717	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acgggcctcccattgtggctCcagaccacgggggcgccagc	6	5	14	16	3	0	1	0	0	0	1	2	1	2	1	5	4	1	1	5	4	0	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr2:220422717C>T	uc010fwk.2	-	11	3675	c.3618G>A	c.(3616-3618)TGG>TGA	p.W1206*	OBSL1_uc002vmh.1_Nonsense_Mutation_p.W197*|OBSL1_uc010zli.1_Nonsense_Mutation_p.W105*|OBSL1_uc010fwl.1_Nonsense_Mutation_p.W681*	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1206	Ig-like 10.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CATTGTGGCTCCAGACCACGG	0.687													4	12					0	0	0	0	T	220422717	T	T	220422717	4	4	96	1	0	0	0	0	0	1	0	0	10867	856	30	2	2139	2	OBSL1	2	220422717	Nonsense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	106908687	220422717	22776656	8	18491											
WDFY1	57590	broad.mit.edu	37	chr2	224749380	224749380	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcacttgtcttagccccagCgtcttggtgtcccacatctg	5	13	8	15	1	4	0	1	0	3	0	5	0	5	0	3	1	2	0	3	1	1	3	rs140777534		TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr2:224749380C>G	uc002vnq.2	-	9	969	c.918G>C	c.(916-918)ACG>ACC	p.T306T		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	306	FYVE-type.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		TTAGCCCCAGCGTCTTGGTGT	0.453													57	208					0	0	0	0	G	224749380	G	G	224749380	2	3	96	1	0	0	0	0	0	0	0	1	17336	755	27	3		3	WDFY1	2	224749380	Silent	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	4326663	224749380	18449993	9	18492											
SP110	3431	broad.mit.edu	37	chr2	231067413	231067413	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatccacccttttgagcttCttttggattccgtgtctaga	6	17	8	10	1	2	3	0	2	2	1	4	4	4	4	3	1	1	1	3	1	1	7			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr2:231067413C>T	uc002vqh.3	-	9	1170	c.930G>A	c.(928-930)AAG>AAA	p.K310K	SP110_uc002vqg.3_Silent_p.K310K|SP110_uc002vqi.3_Silent_p.K310K|SP110_uc010fxk.2_Silent_p.K308K|SP110_uc010fxj.2_Intron	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	310					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		TTTTGAGCTTCTTTTGGATTC	0.458													27	84					0	0	0	0	T	231067413	T	T	231067413	2	4	96	1	0	0	0	0	0	0	0	1	15025	912	32	2		2	SP110	2	231067413	Silent	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	6318033	231067413	12131960	10	18493											
FGD5	152273	broad.mit.edu	37	chr3	14862067	14862067	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggctatgtcccagaaaccGtccctgaagaaaccggacct	11	6	9	15	3	0	3	0	1	0	2	2	4	2	4	6	2	2	1	6	2	4	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr3:14862067G>A	uc003bzc.2	+	1	1599	c.1489G>A	c.(1489-1491)GTC>ATC	p.V497I	FGD5_uc011avk.1_Missense_Mutation_p.V497I	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	497					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CCCAGAAACCGTCCCTGAAGA	0.642													5	36					0	0	0	0	A	14862067	A	A	14862067	3	1	96	1	0	0	0	0	1	0	0	0	5868	1145	40	1	1491	1	FGD5	3	14862067	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08		14862067	183160363	11	18494											
SENP7	57337	broad.mit.edu	37	chr3	101066766	101066766	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggtctgaatctcttgaagaTaatctgaagagacccagaag	14	9	11	7	0	3	6	0	3	3	3	4	7	3	6	1	1	0	0	1	1	5	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr3:101066766T>C	uc003dut.2	-	13	1898	c.1787A>G	c.(1786-1788)TAT>TGT	p.Y596C	SENP7_uc003duu.2_Missense_Mutation_p.Y531C|SENP7_uc003duv.2_Missense_Mutation_p.Y563C|SENP7_uc003duw.2_Missense_Mutation_p.Y530C|SENP7_uc003dux.2_Missense_Mutation_p.Y432C	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	596					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						CTCTTGAAGATAATCTGAAGA	0.338													19	71					0	0	0	0	C	101066766	C	C	101066766	3	2	96	1	0	0	0	0	1	0	0	0	14116	1406	49	5	1413	5	SENP7	3	101066766	Missense_Mutation	SNP	T	TCGA-CQ-5330-01A-01D-1683-08	86204699	101066766	96955664	12	18495											
EPHB1	2047	broad.mit.edu	37	chr3	134880873	134880873	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttaggaacacaatgagtTcaactcctccatggccagga	12	10	8	11	0	1	1	1	1	0	0	3	3	3	3	3	3	2	1	3	3	4	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr3:134880873T>G	uc003eqt.2	+	7	1656	c.1436T>G	c.(1435-1437)TTC>TGC	p.F479C	EPHB1_uc003equ.2_Missense_Mutation_p.F40C	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	479	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CACAATGAGTTCAACTCCTCC	0.547													3	73					0	0	0	0	G	134880873	G	G	134880873	3	3	96	1	0	0	0	0	1	0	0	0	5198	1783	62	5	1462	5	EPHB1	3	134880873	Missense_Mutation	SNP	T	TCGA-CQ-5330-01A-01D-1683-08	33814107	134880873	63141557	13	18496											
ZIC4	84107	broad.mit.edu	37	chr3	147113851	147113851	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggccgccgacgtgctccacgGtgacgtgcgtgaccagctcg	5	6	15	15	7	0	2	0	2	0	0	2	3	1	2	4	2	3	2	4	2	0	0			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr3:147113851G>A	uc003ewd.1	-	3	749	c.476C>T	c.(475-477)ACC>ATC	p.T159I	ZIC4_uc003ewc.1_Missense_Mutation_p.T89I|ZIC4_uc011bno.1_Missense_Mutation_p.T209I	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	159	C2H2-type 1; atypical.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GTGCTCCACGGTGACGTGCGT	0.612													4	128					0	0	0	0	A	147113851	A	A	147113851	3	1	96	1	0	0	0	0	1	0	0	0	17748	1261	44	4	540	4	ZIC4	3	147113851	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	12232978	147113851	50908579	14	18497											
NCBP2	22916	broad.mit.edu	37	chr3	196669371	196669371	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccttcaggaggccacccgAcatagtgcagagaagcggac	11	4	13	13	3	1	1	1	0	0	1	1	5	1	3	3	3	2	1	3	3	2	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr3:196669371A>T	uc003fxd.1	-	1	94	c.4T>A	c.(4-6)TCG>ACG	p.S2T	NCBP2_uc003fxb.1_5'Flank|NCBP2_uc011btz.1_5'Flank|NCBP2_uc003fxc.1_RNA|NCBP2_uc003fxe.1_Missense_Mutation_p.S2T|NCBP2_uc003fxf.2_Missense_Mutation_p.S2T|LOC152217_uc003fxg.3_5'Flank	NM_007362	NP_031388	P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	2					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding				0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		AGGCCACCCGACATAGTGCAG	0.682											OREG0016012	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	14					0	0	0	0	T	196669371	T	T	196669371	3	4	96	1	0	0	0	0	1	0	0	0	10266	275	10	5	482	5	NCBP2	3	196669371	Missense_Mutation	SNP	A	TCGA-CQ-5330-01A-01D-1683-08	49555520	196669371	1353059	15	18498											
NCAPG	64151	broad.mit.edu	37	chr4	17827167	17827167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagcaacttgaaattaaaGaagtccacatagagaaggta	19	7	9	6	0	0	4	0	1	0	3	1	5	1	4	1	1	2	2	1	1	8	4			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr4:17827167G>A	uc003gpp.2	+	11	1812	c.1636G>A	c.(1636-1638)GAA>AAA	p.E546K	NCAPG_uc011bxj.1_Missense_Mutation_p.E55K	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	546					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		TGAAATTAAAGAAGTCCACAT	0.308													6	48					0	0	0	0	A	17827167	A	A	17827167	3	1	96	1	0	0	0	0	1	0	0	0	10261	943	33	2	1678	2	NCAPG	4	17827167	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08		17827167	173327109	16	18499											
RBM47	54502	broad.mit.edu	37	chr4	40440251	40440251	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgatctggtggccccacagCtggatgcggccaggcatgag	7	6	16	12	2	1	1	0	1	1	0	1	3	1	2	3	5	2	2	3	5	0	0			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr4:40440251C>T	uc003gvc.2	-	4	1370	c.660G>A	c.(658-660)CAG>CAA	p.Q220Q	RBM47_uc003gvd.2_Silent_p.Q220Q|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Silent_p.Q182Q|RBM47_uc003gvg.1_Silent_p.Q220Q	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	220	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(3)	3						GGCCCCACAGCTGGATGCGGC	0.647													26	44					0	0	0	0	T	40440251	T	T	40440251	2	4	96	1	0	0	0	0	0	0	0	1	13206	796	28	4		4	RBM47	4	40440251	Silent	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	22613084	40440251	150714025	17	18500											
TLL1	7092	broad.mit.edu	37	chr4	167020437	167020437	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcctgggcagagtgtggcGgacgattgaaagcagaatca	11	9	14	7	2	1	3	1	1	0	2	2	5	2	4	1	3	1	2	1	3	2	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr4:167020437G>A	uc003irh.1	+	20	3312	c.2665G>A	c.(2665-2667)GGA>AGA	p.G889R	TLL1_uc011cjn.1_Missense_Mutation_p.G912R|TLL1_uc011cjo.1_Missense_Mutation_p.G713R	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	889	CUB 5.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AGAGTGTGGCGGACGATTGAA	0.418													12	48					0	0	0	0	A	167020437	A	A	167020437	3	1	96	1	0	0	0	0	1	0	0	0	16011	1117	39	1	2743	1	TLL1	4	167020437	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	126580186	167020437	24133839	18	18501											
DNAH5	1767	broad.mit.edu	37	chr5	13701428	13701428	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taaaaatccctgggggttaaAaaaacccgtcatccaaaagc	17	7	7	10	1	1	0	1	0	0	0	3	0	3	0	3	2	2	1	3	2	9	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:13701428A>T	uc003jfd.2	-	77	13498	c.13456T>A	c.(13456-13458)TTT>ATT	p.F4486I	DNAH5_uc003jfc.2_Missense_Mutation_p.F654I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4486					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGGGGGTTAAAAAAACCCGTC	0.423									Kartagener_syndrome				63	84					0	0	0	0	T	13701428	T	T	13701428	3	4	96	1	0	0	0	0	1	0	0	0	4626	14	1	5	430	5	DNAH5	5	13701428	Missense_Mutation	SNP	A	TCGA-CQ-5330-01A-01D-1683-08		13701428	167213832	19	18502											
LIFR	3977	broad.mit.edu	37	chr5	38506632	38506632	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaagtgtagcttgtagcaCgtgggcccaccaacgctgtc	9	9	11	12	2	0	0	0	0	0	0	1	0	0	0	2	1	3	5	2	1	5	4			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:38506632C>T	uc010ive.1	-	8	1426	c.1094G>A	c.(1093-1095)CGT>CAT	p.R365H	LIFR_uc003jli.2_Missense_Mutation_p.R365H	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	365	Fibronectin type-III 2.|Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					GCTTGTAGCACGTGGGCCCAC	0.423			T	PLAG1	salivary adenoma								31	51					0	0	0	0	T	38506632	T	T	38506632	3	4	96	1	0	0	0	0	1	0	0	0	8821	536	19	1	2251	1	LIFR	5	38506632	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	24805204	38506632	142408628	20	18503											
MAP1B	4131	broad.mit.edu	37	chr5	71492289	71492289	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagaggaggaatatgagcCggaaaaaatggaagctgaag	18	4	15	4	1	0	3	0	2	0	1	0	8	0	7	1	4	2	1	1	4	7	1	rs145156470	byFrequency	TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:71492289C>T	uc003kbw.3	+	5	3348	c.3107C>T	c.(3106-3108)CCG>CTG	p.P1036L	MAP1B_uc010iyw.1_Missense_Mutation_p.P1053L|MAP1B_uc010iyx.1_Missense_Mutation_p.P910L|MAP1B_uc010iyy.1_Missense_Mutation_p.P910L	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1036						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GAATATGAGCCGGAAAAAATG	0.522													21	49					0	0	0	0	T	71492289	T	T	71492289	3	4	96	1	0	0	0	0	1	0	0	0	9281	652	23	1	3125	1	MAP1B	5	71492289	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	32985657	71492289	109422971	21	18504											
CHD1	1105	broad.mit.edu	37	chr5	98233025	98233025	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggcctttgttttaatacCtttagtagaaataaacatta	13	17	5	6	0	0	1	0	0	0	1	0	1	0	1	2	1	2	2	2	1	8	10			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:98233025C>T	uc003knf.2	-	10	1514	c.1366_splice	c.e10-1	p.V456_splice		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	GTTTTAATACCTTTAGTAGAA	0.308													17	54					0	0	0	0	T	98233025	T	T	98233025	5	4	96	1	0	0	0	0	0	0	1	0	3338	695	24	4	3871	4	CHD1	5	98233025	Splice_Site	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	26740736	98233025	82682235	22	18505											
PCDHA13	56136	broad.mit.edu	37	chr5	140264049	140264049	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgcccaccgagggcgcgtgCgcgccgggcaagcccactct	5	3	14	19	7	1	0	0	0	1	0	1	1	1	0	5	2	2	1	5	2	1	0			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:140264049C>T	uc003lif.2	+	1	2196	c.2196C>T	c.(2194-2196)TGC>TGT	p.C732C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.C732C|PCDHA13_uc003lid.2_Silent_p.C732C	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	732	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGGCGCGTGCGCGCCGGGCA	0.672													28	64					0	0	0	0	T	140264049	T	T	140264049	2	4	96	1	0	0	0	0	0	0	0	1	11577	776	27	1		1	PCDHA13	5	140264049	Silent	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	42031024	140264049	40651211	23	18506											
DUSP22	56940	broad.mit.edu	37	chr6	348266	348266	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggagtttgagaagcatgagGtccatcaggtaagcagttct	12	10	13	6	0	2	2	1	2	1	1	3	4	3	3	1	3	2	5	1	3	2	3	rs147464089	byFrequency	TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr6:348266G>T	uc003msx.2	+	6	866	c.427G>T	c.(427-429)GTC>TTC	p.V143F	DUSP22_uc011dhn.1_Missense_Mutation_p.V143F|DUSP22_uc003msy.1_Missense_Mutation_p.V100F	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	143					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		GAAGCATGAGGTCCATCAGGT	0.582													4	46					2.56e-06	2.88e-06	1	0	T	348266	T	T	348266	3	4	96	1	0	0	0	0	1	0	0	0	4843	1261	44	4	449	4	DUSP22	6	348266	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08		348266	170766801	24	18507											
SLC26A8	116369	broad.mit.edu	37	chr6	35919019	35919019	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggagcctatgaccttcCttgacaaggcaaacagcacg	13	6	10	12	1	0	3	0	2	0	1	1	4	1	4	3	2	3	2	3	2	3	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr6:35919019C>A	uc003olm.2	-	19	2504	c.2393G>T	c.(2392-2394)AGG>ATG	p.R798M	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.R380M|SLC26A8_uc003oln.2_Missense_Mutation_p.R798M|SLC26A8_uc003oll.2_Missense_Mutation_p.R693M	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	798	Interaction with RACGAP1.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						TATGACCTTCCTTGACAAGGC	0.493													15	43					4.14922e-12	4.77642e-12	1	0	A	35919019	A	A	35919019	3	1	96	1	0	0	0	0	1	0	0	0	14587	681	24	4	527	4	SLC26A8	6	35919019	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	35570753	35919019	135196048	25	18508											
RSPO3	84870	broad.mit.edu	37	chr6	127476478	127476478	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggactgaaacacgggtcCgagaaataatacagcatcct	15	6	11	9	2	0	2	0	1	0	1	2	5	2	3	2	2	3	1	2	2	4	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr6:127476478C>T	uc003qar.2	+	4	819	c.529C>T	c.(529-531)CGA>TGA	p.R177*	RSPO3_uc003qas.1_Nonsense_Mutation_p.R177*	NM_032784	NP_116173	Q9BXY4	RSPO3_HUMAN	R-spondin 3 precursor	177	TSP type-1.					extracellular region	heparin binding				0				GBM - Glioblastoma multiforme(226;0.0555)		AACACGGGTCCGAGAAATAAT	0.463													28	58					0	0	0	0	T	127476478	T	T	127476478	4	4	96	1	0	0	0	0	0	1	0	0	13776	644	23	1	543	1	RSPO3	6	127476478	Nonsense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	91557459	127476478	43638589	26	18509											
ACTB	60	broad.mit.edu	37	chr7	5567491	5567491	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatggagccgccgatccacAcggagtacttgcgctcagga	9	6	14	12	4	1	0	1	0	0	0	2	5	2	4	3	4	3	2	3	4	1	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr7:5567491A>G	uc003sos.3	-	5	1052	c.1016T>C	c.(1015-1017)GTG>GCG	p.V339A	ACTB_uc003sor.3_Missense_Mutation_p.V217A|ACTB_uc003sot.3_Missense_Mutation_p.V339A|ACTB_uc003soq.3_Missense_Mutation_p.V217A|ACTB_uc010ksy.2_Missense_Mutation_p.V217A	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	339					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		GCCGATCCACACGGAGTACTT	0.622													9	36					0	0	0	0	G	5567491	G	G	5567491	3	3	96	1	0	0	0	0	1	0	0	0	193	159	6	5	115	5	ACTB	7	5567491	Missense_Mutation	SNP	A	TCGA-CQ-5330-01A-01D-1683-08		5567491	153571172	27	18510											
SAMD9L	219285	broad.mit.edu	37	chr7	92762359	92762359	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtatctcccatattctgcaaCttctgtttttattagaagtg	9	18	6	8	0	3	1	0	0	3	1	4	1	3	1	1	0	2	3	1	0	6	8			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr7:92762359C>T	uc003umh.1	-	5	4142	c.2926G>A	c.(2926-2928)GTT>ATT	p.V976I	SAMD9L_uc003umj.1_Missense_Mutation_p.V976I|SAMD9L_uc003umi.1_Missense_Mutation_p.V976I|SAMD9L_uc010lfb.1_Missense_Mutation_p.V976I|SAMD9L_uc003umk.1_Missense_Mutation_p.V976I|SAMD9L_uc010lfc.1_Missense_Mutation_p.V976I|SAMD9L_uc010lfd.1_Missense_Mutation_p.V976I|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	976										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TATTCTGCAACTTCTGTTTTT	0.383													18	47					0	0	0	0	T	92762359	T	T	92762359	3	4	96	1	0	0	0	0	1	0	0	0	13892	565	20	4	1832	4	SAMD9L	7	92762359	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	87194868	92762359	66376304	28	18511											
TUSC3	7991	broad.mit.edu	37	chr8	15601052	15601052	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgacaactactgcagatgccGctatcaccatggggatggtt	10	10	11	10	1	1	2	1	1	0	1	1	3	1	3	2	3	4	3	2	3	3	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:15601052G>A	uc003wwt.2	+	8	1078	c.868G>A	c.(868-870)GCT>ACT	p.A290T	TUSC3_uc003wwu.2_Missense_Mutation_p.A290T|TUSC3_uc003wwv.2_Missense_Mutation_p.A290T|TUSC3_uc003www.2_Missense_Mutation_p.A290T|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Silent_p.P268P	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	290	Helical; (Potential).				cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		TGCAGATGCCGCTATCACCAT	0.393													45	46					0	0	0	0	A	15601052	A	A	15601052	3	1	96	1	0	0	0	0	1	0	0	0	16846	1087	38	1	898	1	TUSC3	8	15601052	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08		15601052	130762970	29	18512											
RP1	6101	broad.mit.edu	37	chr8	55539978	55539978	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagaggaagctgatgactTgaaagctgctgttgccaatt	12	10	11	8	0	0	4	0	3	0	1	0	5	0	5	1	1	4	4	1	1	3	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:55539978T>C	uc003xsd.1	+	4	3684	c.3536T>C	c.(3535-3537)TTG>TCG	p.L1179S	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1179					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GCTGATGACTTGAAAGCTGCT	0.408													3	176					0	0	0	0	C	55539978	C	C	55539978	3	2	96	1	0	0	0	0	1	0	0	0	13597	1821	63	5	3546	5	RP1	8	55539978	Missense_Mutation	SNP	T	TCGA-CQ-5330-01A-01D-1683-08	39938926	55539978	90824044	30	18513											
ZFHX4	79776	broad.mit.edu	37	chr8	77775641	77775641	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctctttcagtgttgggcAaagttgtaggtgaaacacat	10	13	11	7	0	2	1	1	1	1	0	2	1	2	1	0	2	2	5	0	2	3	4			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:77775641A>G	uc003yav.2	+	11	9943	c.9556A>G	c.(9556-9558)AAA>GAA	p.K3186E		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3182						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGTGTTGGGCAAAGTTGTAGG	0.438										HNSCC(33;0.089)			13	144					0	0	0	0	G	77775641	G	G	77775641	3	3	96	1	0	0	0	0	1	0	0	0	17702	131	5	5	9729	5	ZFHX4	8	77775641	Missense_Mutation	SNP	A	TCGA-CQ-5330-01A-01D-1683-08	22235663	77775641	68588381	31	18514											
RALYL	138046	broad.mit.edu	37	chr8	85799858	85799858	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagctcagaagaagcaattGgaagagagtctagtgctgat	15	8	13	5	0	2	4	1	1	1	3	2	7	2	5	0	1	3	3	0	1	6	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:85799858G>A	uc003ycq.3	+	9	1121	c.705G>A	c.(703-705)TTG>TTA	p.L235L	RALYL_uc003ycr.3_Silent_p.L235L|RALYL_uc003ycs.3_Silent_p.L235L|RALYL_uc010lzy.2_Silent_p.L224L|RALYL_uc003yct.3_Silent_p.L248L|RALYL_uc003ycu.3_Silent_p.L162L|RALYL_uc003ycv.3_Intron	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	235	Potential.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						AGAAGCAATTGGAAGAGAGTC	0.488													10	108					0	0	0	0	A	85799858	A	A	85799858	2	1	96	1	0	0	0	0	0	0	0	1	13085	1339	47	4		4	RALYL	8	85799858	Silent	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	8024217	85799858	60564164	32	18515											
CYP11B1	1584	broad.mit.edu	37	chr8	143957228	143957228	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcggccaggctctcctggcGcagggcctgctgcacgttgg	3	7	17	14	3	1	0	0	0	1	0	2	0	1	0	3	6	2	5	3	6	0	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:143957228G>A	uc003yxi.2	-	6	1028	c.1021C>T	c.(1021-1023)CGC>TGC	p.R341C	CYP11B1_uc010mex.2_Missense_Mutation_p.R17C|CYP11B1_uc003yxh.2_Missense_Mutation_p.R57C|CYP11B1_uc003yxj.2_Missense_Mutation_p.R341C|CYP11B1_uc010mey.2_Missense_Mutation_p.R412C	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	341					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CTCTCCTGGCGCAGGGCCTGC	0.642									Familial_Hyperaldosteronism_type_I				93	81					0	0	0	0	A	143957228	A	A	143957228	3	1	96	1	0	0	0	0	1	0	0	0	4162	1087	38	1	506	1	CYP11B1	8	143957228	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	58157370	143957228	2406794	33	18516											
NAPRT1	93100	broad.mit.edu	37	chr8	144657851	144657851	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccacactggtgccaatgcCaatgacattcacctcactgc	11	8	7	15	0	2	1	2	1	0	0	2	2	2	1	4	1	3	0	4	1	2	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:144657851C>T	uc003yym.3	-	9	1154	c.1129G>A	c.(1129-1131)GGC>AGC	p.G377S	C8orf73_uc010mff.2_5'Flank|C8orf73_uc010mfg.1_5'Flank|NAPRT1_uc003yyn.3_Missense_Mutation_p.G377S|NAPRT1_uc011lkh.1_Missense_Mutation_p.G377S|NAPRT1_uc003yyo.3_Missense_Mutation_p.G377S	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	377					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GTGCCAATGCCAATGACATTC	0.667													5	7					0	0	0	0	T	144657851	T	T	144657851	3	4	96	1	0	0	0	0	1	0	0	0	10218	594	21	4	507	4	NAPRT1	8	144657851	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	700623	144657851	1706171	34	18517											
CDKN2A	1029	broad.mit.edu	37	chr9	21971045	21971059	+	In_Frame_Del	DEL	CCAGCCGCGCCCCGG	-	-																															gccccaggcatcgcgcacgtCcagccgcgccccggcccggt																								rs143282362		TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr9:21971045_21971059delCCAGCCGCGCCCCGG	uc003zpk.2	-	2	511_525	c.299_313delCCGGGGCGCGGCTGG	c.(298-315)GCCGGGGCGCGGCTGGAC>GAC	p.AGARL100del	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_In_Frame_Del_p.155_160GRGAAG>G	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	100_104	ANK 3.		Missing.		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.G101G(3)|p.A100S(3)|p.A102V(3)|p.L104fs*42(2)|p.D105fs*41(2)|p.A102A(2)|p.A102E(2)|p.A100P(2)|p.H83fs*2(2)|p.R103Q(1)|p.R103R(1)|p.T93_D105del(1)|p.A100V(1)|p.G101fs*17(1)|p.A68fs*3(1)|p.A102fs*18(1)|p.R103fs*43(1)|p.G101W(1)|p.D105N(1)|p.A102P(1)|p.A102T(1)|p.A102fs*42(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCGCGCACGTCCAGCCGCGCCCCGGCCCGGTGCAG	0.758		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---								-	21971059	-	-	21971045	7	5	96	1	0	1	0	1	0	0	0	0	3176	855	30	0	165	0	CDKN2A	9	21971045	In_Frame_Del	DEL	CCAGCCGCGCCCCGG	TCGA-CQ-5330-01A-01D-1683-08		21971045	119242386	35	18518											
AGTPBP1	23287	broad.mit.edu	37	chr9	88203249	88203249	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctggatttaacatagggAcaattttaaaaatataagat	18	13	6	4	0	1	1	0	0	1	1	1	3	1	3	0	2	1	0	0	2	8	7			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr9:88203249A>C	uc011ltd.1	-	20	2900	c.2867T>G	c.(2866-2868)GTC>GGC	p.V956G	AGTPBP1_uc004aod.3_Missense_Mutation_p.V582G|AGTPBP1_uc011ltc.1_Intron|AGTPBP1_uc010mqc.2_Missense_Mutation_p.V916G|AGTPBP1_uc011lte.1_Missense_Mutation_p.V968G	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	956					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						TAACATAGGGACAATTTTAAA	0.348													13	30					0	0	0	0	C	88203249	C	C	88203249	3	2	96	1	0	0	0	0	1	0	0	0	400	275	10	5	837	5	AGTPBP1	9	88203249	Missense_Mutation	SNP	A	TCGA-CQ-5330-01A-01D-1683-08	66232204	88203249	53010182	36	18519											
OMD	4958	broad.mit.edu	37	chr9	95177520	95177520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgagcattgtcaggatcatCgtgatcttcactttcatcat	10	15	7	9	1	6	2	5	2	1	0	7	3	6	3	0	1	1	1	0	1	0	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr9:95177520C>T	uc004asd.3	-	3	1549	c.1180G>A	c.(1180-1182)GAT>AAT	p.D394N	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron	NM_005014	NP_005005	Q99983	OMD_HUMAN	osteomodulin precursor	394	Asp/Glu-rich (acidic).				cell adhesion	proteinaceous extracellular matrix				ovary(2)	2						TCAGGATCATCGTGATCTTCA	0.368			T	USP6	aneurysmal bone cysts								26	38					0	0	0	0	T	95177520	T	T	95177520	3	4	96	1	0	0	0	0	1	0	0	0	10919	884	31	1	89	1	OMD	9	95177520	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	6974271	95177520	46035911	37	18520											
BSPRY	54836	broad.mit.edu	37	chr9	116132021	116132021	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagatggcccggagcgcttcGaccactggcccaatgccctg	7	6	12	16	3	0	1	0	0	0	1	1	3	0	2	4	3	2	1	4	3	1	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr9:116132021G>A	uc004bhg.3	+	6	856	c.808G>A	c.(808-810)GAC>AAC	p.D270N	BSPRY_uc010muw.2_3'UTR	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	270	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						GGAGCGCTTCGACCACTGGCC	0.577													15	51					0	0	0	0	A	116132021	A	A	116132021	3	1	96	1	0	0	0	0	1	0	0	0	1537	1058	37	1	830	1	BSPRY	9	116132021	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	20954501	116132021	25081410	38	18521											
SEC16A	9919	broad.mit.edu	37	chr9	139371059	139371059	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggctatctccccgggcgaGggggttcacaagagcagagg	8	6	17	10	2	2	2	1	0	1	2	3	3	2	2	2	5	1	3	2	5	2	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr9:139371059G>A	uc004chx.2	-	3	1318	c.1009C>T	c.(1009-1011)CTC>TTC	p.L337F	SEC16A_uc004chv.3_5'Flank|SEC16A_uc004chw.2_Missense_Mutation_p.L337F|SEC16A_uc010nbn.2_Missense_Mutation_p.L337F|SEC16A_uc010nbo.1_Missense_Mutation_p.L337F	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	159					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CCCCGGGCGAGGGGGTTCACA	0.617													7	39					0	0	0	0	A	139371059	A	A	139371059	3	1	96	1	0	0	0	0	1	0	0	0	14051	1000	35	4	6184	4	SEC16A	9	139371059	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	23239038	139371059	1842372	39	18522											
TMEM72	643236	broad.mit.edu	37	chr10	45430313	45430313	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcccttttcatccacatgAagagtatcctgaaggggact	10	11	9	11	0	1	3	1	2	0	1	4	4	4	4	3	2	0	2	3	2	3	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr10:45430313A>G	uc001jbn.2	+	5	756	c.559A>G	c.(559-561)AAG>GAG	p.K187E	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Missense_Mutation_p.K69E	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	187						integral to membrane					0						CATCCACATGAAGAGTATCCT	0.602													46	156					0	0	0	0	G	45430313	G	G	45430313	3	3	96	1	0	0	0	0	1	0	0	0	16267	247	9	5	577	5	TMEM72	10	45430313	Missense_Mutation	SNP	A	TCGA-CQ-5330-01A-01D-1683-08		45430313	90104434	40	18523											
PSAP	5660	broad.mit.edu	37	chr10	73578462	73578462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaacaagggcttatgggccGaggggcaggctccaattttc	9	8	13	11	1	0	0	0	0	0	0	2	1	1	0	3	5	1	3	3	5	4	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr10:73578462G>A	uc001jsm.2	-	13	1555	c.1451C>T	c.(1450-1452)TCG>TTG	p.S484L	PSAP_uc001jsl.2_Missense_Mutation_p.S208L	NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	484	Saposin B-type 4.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						CTTATGGGCCGAGGGGCAGGC	0.488													8	125					0	0	0	0	A	73578462	A	A	73578462	3	1	96	1	0	0	0	0	1	0	0	0	12705	1059	37	1	131	1	PSAP	10	73578462	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	28148149	73578462	61956285	41	18524											
ARL3	403	broad.mit.edu	37	chr10	104445679	104445679	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagaggcaggggctgctGtgagcaaatcctgcttatta	9	12	12	8	0	1	2	1	1	0	1	2	2	2	2	1	3	3	5	1	3	3	3	rs150077149		TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr10:104445679G>A	uc001kwa.2	-	5	553	c.395C>T	c.(394-396)ACA>ATA	p.T132I		NM_004311	NP_004302	P36405	ARL3_HUMAN	ADP-ribosylation factor-like 3	132					cell cycle|cytokinesis|small GTPase mediated signal transduction	centrosome|cytoplasmic microtubule|Golgi membrane|midbody|nucleus|photoreceptor connecting cilium|spindle microtubule	GDP binding|GTP binding|metal ion binding|microtubule binding				0		Colorectal(252;0.122)		Epithelial(162;4.88e-09)|all cancers(201;1.29e-07)|BRCA - Breast invasive adenocarcinoma(275;0.22)		AGGGGCTGCTGTGAGCAAATC	0.507													15	43					0	0	0	0	A	104445679	A	A	104445679	3	1	96	1	0	0	0	0	1	0	0	0	937	1377	48	4	161	4	ARL3	10	104445679	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	30867217	104445679	31089068	42	18525											
TH	7054	broad.mit.edu	37	chr11	2191095	2191095	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctgcgcccaatgaaccGcggggactgtggggacaagg	8	5	16	12	3	0	1	0	1	0	0	0	3	0	3	3	5	3	0	3	5	3	0			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr11:2191095G>A	uc001lvq.2	-	3	209	c.190C>T	c.(190-192)CGG>TGG	p.R64W	TH_uc001lvp.2_Missense_Mutation_p.R60W|TH_uc001lvr.2_Missense_Mutation_p.R33W|TH_uc010qxj.1_Missense_Mutation_p.R37W|TH_uc001lvs.2_Missense_Mutation_p.R33W|TH_uc001lvt.2_Missense_Mutation_p.R37W|TH_uc009ydh.1_5'Flank	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	64					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	CCAATGAACCGCGGGGACTGT	0.721													3	10					0	0	0	0	A	2191095	A	A	2191095	3	1	96	1	0	0	0	0	1	0	0	0	15904	1086	38	1	1444	1	TH	11	2191095	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08		2191095	132815421	43	18526											
AHNAK	79026	broad.mit.edu	37	chr11	62290908	62290908	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgatgttcatctcaggcaTcttgaacttggggcccttca	7	15	9	10	0	4	2	3	2	2	0	5	2	4	2	1	3	1	2	1	3	1	5			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr11:62290908T>C	uc001ntl.2	-	5	11281	c.10981A>G	c.(10981-10983)ATG>GTG	p.M3661V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3661					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATCTCAGGCATCTTGAACTTG	0.468													55	177					0	0	0	0	C	62290908	C	C	62290908	3	2	96	1	0	0	0	0	1	0	0	0	414	1435	50	5	6811	5	AHNAK	11	62290908	Missense_Mutation	SNP	T	TCGA-CQ-5330-01A-01D-1683-08	60099813	62290908	72715608	44	18527											
PYGM	5837	broad.mit.edu	37	chr11	64521023	64521023	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatctcggagtggatgcgCgccacgccgttgacggcgtg	6	7	17	11	7	1	1	0	1	1	0	2	4	1	4	2	4	1	1	2	4	0	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr11:64521023C>T	uc001oax.3	-	11	2188	c.1371G>A	c.(1369-1371)GCG>GCA	p.A457A	PYGM_uc001oay.3_Silent_p.A369A	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	457					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	AGTGGATGCGCGCCACGCCGT	0.652													3	5					0	0	0	0	T	64521023	T	T	64521023	2	4	96	1	0	0	0	0	0	0	0	1	12927	755	27	1		1	PYGM	11	64521023	Silent	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	2230115	64521023	70485493	45	18528											
FEZ1	9638	broad.mit.edu	37	chr11	125359382	125359382	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcctcgtcctgaagggtctCctcctcctcttggatctgta	4	14	8	15	1	3	1	0	1	3	0	9	2	7	2	5	2	0	1	5	2	2	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr11:125359382C>A	uc001qbx.2	-	2	444	c.292G>T	c.(292-294)GAG>TAG	p.E98*	FEZ1_uc010sbc.1_Nonsense_Mutation_p.E98*|FEZ1_uc001qby.1_Nonsense_Mutation_p.E98*	NM_005103	NP_005094	Q99689	FEZ1_HUMAN	zygin 1 isoform 1	98	Poly-Glu.				axon guidance|cell adhesion|transport	microtubule|plasma membrane				central_nervous_system(3)|ovary(1)	4	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		TGAAGGGTCTCCTCCTCCTCT	0.493													7	61					0.00198382	0.00215822	1	0	A	125359382	A	A	125359382	4	1	96	1	0	0	0	0	0	1	0	0	5855	864	30	2	926	2	FEZ1	11	125359382	Nonsense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	60838359	125359382	9647134	46	18529											
HSP90B1	7184	broad.mit.edu	37	chr12	104340443	104340443	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaattaatcccagacaccCgctgatcagagacatgcttc	13	9	7	12	1	1	4	1	2	0	2	3	5	2	4	2	0	1	2	2	0	2	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr12:104340443C>T	uc001tkb.1	+	15	2180	c.2075C>T	c.(2074-2076)CCG>CTG	p.P692L	HSP90B1_uc010swg.1_Missense_Mutation_p.P357L|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	692					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CCCAGACACCCGCTGATCAGA	0.323													14	60					0	0	0	0	T	104340443	T	T	104340443	3	4	96	1	0	0	0	0	1	0	0	0	7442	652	23	1	2133	1	HSP90B1	12	104340443	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08		104340443	29511452	47	18530											
KSR2	283455	broad.mit.edu	37	chr12	118199176	118199176	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagtggggctggtgtgacaaTagtgctggacgcacttggac	8	9	17	7	1	0	1	0	1	0	0	0	4	0	3	0	5	1	3	0	5	2	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr12:118199176T>C	uc001two.2	-	4	594	c.539A>G	c.(538-540)TAT>TGT	p.Y180C		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	209	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGTGACAATAGTGCTGGAC	0.687													7	19					0	0	0	0	C	118199176	C	C	118199176	3	2	96	1	0	0	0	0	1	0	0	0	8622	1406	49	5	2294	5	KSR2	12	118199176	Missense_Mutation	SNP	T	TCGA-CQ-5330-01A-01D-1683-08	13858733	118199176	15652719	48	18531											
GCN1L1	10985	broad.mit.edu	37	chr12	120621395	120621395	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgttccagatgtctccttGtcgcttggctctcgatggaa	5	16	10	10	2	2	1	0	0	2	1	6	3	3	2	2	2	0	3	2	2	1	4			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr12:120621395G>T	uc001txo.2	-	5	416	c.403C>A	c.(403-405)CAA>AAA	p.Q135K		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	135					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ATGTCTCCTTGTCGCTTGGCT	0.542													3	73					0.00909568	0.0096825	1	0	T	120621395	T	T	120621395	3	4	96	1	0	0	0	0	1	0	0	0	6334	1386	48	4	7828	4	GCN1L1	12	120621395	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	2422219	120621395	13230500	49	18532											
FEM1B	10116	broad.mit.edu	37	chr15	68582025	68582025	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttaaacttctagtcagccAtggagccaacgtgaaccata	13	10	8	10	1	2	1	1	1	1	0	2	2	2	2	3	1	5	1	3	1	6	4			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr15:68582025A>G	uc002arg.2	+	2	944	c.329A>G	c.(328-330)CAT>CGT	p.H110R	FEM1B_uc002arh.2_Missense_Mutation_p.H30R	NM_015322	NP_056137	Q9UK73	FEM1B_HUMAN	fem-1 homolog b	110	ANK 2.				apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity				0						CTAGTCAGCCATGGAGCCAAC	0.448													10	24					0	0	0	0	G	68582025	G	G	68582025	3	3	96	1	0	0	0	0	1	0	0	0	5842	217	8	5	335	5	FEM1B	15	68582025	Missense_Mutation	SNP	A	TCGA-CQ-5330-01A-01D-1683-08		68582025	33949367	50	18533											
DNAH3	55567	broad.mit.edu	37	chr16	20999384	20999384	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tattcagatggcgagtgaatCgtcctggggaatacaacaca	13	9	11	8	2	1	2	1	1	0	1	3	4	2	3	1	3	2	0	1	3	5	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr16:20999384C>T	uc010vbe.1	-	45	6605	c.6605G>A	c.(6604-6606)CGA>CAA	p.R2202Q	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2202	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCGAGTGAATCGTCCTGGGGA	0.453													14	46					0	0	0	0	T	20999384	T	T	20999384	3	4	96	1	0	0	0	0	1	0	0	0	4625	884	31	1	5816	1	DNAH3	16	20999384	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08		20999384	69355369	51	18534											
PHKB	5257	broad.mit.edu	37	chr16	47644777	47644777	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagacattgatcctgtccaGcgctatgtcccactaaagga	13	9	8	11	1	0	2	0	1	0	1	3	3	3	3	3	1	1	1	3	1	4	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr16:47644777G>A	uc002eev.3	+	14	1456	c.1404G>A	c.(1402-1404)CAG>CAA	p.Q468Q	PHKB_uc002eeu.3_Silent_p.Q461Q	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	468					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				ATCCTGTCCAGCGCTATGTCC	0.338													13	34					0	0	0	0	A	47644777	A	A	47644777	2	1	96	1	0	0	0	0	0	0	0	1	11900	962	34	4		4	PHKB	16	47644777	Silent	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	26645393	47644777	42709976	52	18535											
RPGRIP1L	23322	broad.mit.edu	37	chr16	53686477	53686477	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtacaaaatattcggcCgcttttttcaagaatttcgt	10	16	7	8	3	1	1	1	0	0	1	3	1	1	1	1	1	2	3	1	1	6	7			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr16:53686477C>A	uc002ehp.2	-	15	2186	c.2122G>T	c.(2122-2124)GGC>TGC	p.G708C	RPGRIP1L_uc002eho.3_Missense_Mutation_p.G708C|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.G708C|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.G708C|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.G708C	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	708	C2 1.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				AATATTCGGCCGCTTTTTTCA	0.348													14	38					0.00316338	0.00340407	1	0	A	53686477	A	A	53686477	3	1	96	1	0	0	0	0	1	0	0	0	13615	652	23	3	1877	3	RPGRIP1L	16	53686477	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	6041700	53686477	36668276	53	18536											
CBFA2T3	863	broad.mit.edu	37	chr16	88958773	88958773	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgccgggccccgcaggctGggggcaggtgctgtgtggac	3	6	20	12	2	0	0	0	0	0	0	0	1	0	1	3	6	2	5	3	6	0	0			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr16:88958773G>T	uc002fmm.1	-	4	686	c.500C>A	c.(499-501)CCA>CAA	p.P167Q	CBFA2T3_uc002fml.1_Missense_Mutation_p.P81Q|CBFA2T3_uc010cif.1_Missense_Mutation_p.P106Q|CBFA2T3_uc002fmn.1_Missense_Mutation_p.P142Q	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	167	Mediates localization to the nucleus (By similarity).|Mediates interaction with PDE7A (in isoform 2).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CCCGCAGGCTGGGGGCAGGTG	0.647			T	RUNX1	AML								18	23					4.35082e-09	4.95093e-09	1	0	T	88958773	T	T	88958773	3	4	96	1	0	0	0	0	1	0	0	0	2710	1348	47	4	1497	4	CBFA2T3	16	88958773	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	35272296	88958773	1395980	54	18537											
POLR2A	5430	broad.mit.edu	37	chr17	7399844	7399844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgtctacgacctttgcaaggGcaaaaacatatgcgagggtg	12	9	12	8	2	1	0	0	0	1	0	1	2	1	0	1	2	4	2	1	2	5	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr17:7399844G>A	uc002ghf.3	+	4	683	c.449G>A	c.(448-450)GGC>GAC	p.G150D	POLR2A_uc002ghe.2_Missense_Mutation_p.G150D	NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	150					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				CTTTGCAAGGGCAAAAACATA	0.537													4	158					0	0	0	0	A	7399844	A	A	7399844	3	1	96	1	0	0	0	0	1	0	0	0	12269	1203	42	4	463	4	POLR2A	17	7399844	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08		7399844	73795366	55	18538											
TP53	7157	broad.mit.edu	37	chr17	7577142	7577142	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cacctcaaagctgttccgtcCcagtagattaccactactca	11	10	5	15	1	2	1	2	0	0	1	4	1	4	1	4	0	3	3	4	0	4	4			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr17:7577142C>T	uc002gim.2	-	8	990	c.796G>A	c.(796-798)GGA>AGA	p.G266R	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.G266R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G134R|TP53_uc010cng.1_Missense_Mutation_p.G134R|TP53_uc002gii.1_Missense_Mutation_p.G134R|TP53_uc010cnh.1_Missense_Mutation_p.G266R|TP53_uc010cni.1_Missense_Mutation_p.G266R|TP53_uc002gij.2_Missense_Mutation_p.G266R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	266	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G266E(45)|p.G266R(42)|p.G266V(31)|p.G266*(12)|p.0?(7)|p.G266fs*79(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266G(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.G266T(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.G266fs*9(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTGTTCCGTCCCAGTAGATTA	0.517		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	11					0	0	0	0	T	7577142	T	T	7577142	3	4	96	1	0	0	0	0	1	0	0	0	16448	632	22	4	490	4	TP53	17	7577142	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	177298	7577142	73618068	56	18539											
PSMD11	5717	broad.mit.edu	37	chr17	30796051	30796051	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggagttgaaaaagatggaCgacaaagctcttttggtgga	13	9	14	5	2	1	2	0	1	1	1	1	6	1	5	0	4	1	2	0	4	3	3			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr17:30796051C>T	uc010cta.1	+	6	523	c.483C>T	c.(481-483)GAC>GAT	p.D161D	PSMD11_uc010wbz.1_Silent_p.D161D|PSMD11_uc002hhm.2_Silent_p.D161D	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	161					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			AAAAGATGGACGACAAAGCTC	0.448													14	33					0	0	0	0	T	30796051	T	T	30796051	2	4	96	1	0	0	0	0	0	0	0	1	12756	535	19	1		1	PSMD11	17	30796051	Silent	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	23218909	30796051	50399159	57	18540											
NAGS	162417	broad.mit.edu	37	chr17	42083499	42083499	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacggccgcgcgccgctccgTgcttctcgactccctggagg	3	7	14	17	7	1	0	0	0	1	0	4	3	3	1	4	3	1	2	4	3	0	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr17:42083499T>A	uc002ies.2	+	3	809	c.809T>A	c.(808-810)GTG>GAG	p.V270E	PYY_uc002ieq.2_5'Flank|NAGS_uc010czn.2_Missense_Mutation_p.V270E|NAGS_uc002iet.2_5'UTR	NM_153006	NP_694551	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	270					arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity				0		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	CGCCGCTCCGTGCTTCTCGAC	0.667													10	16					0	0	0	0	A	42083499	A	A	42083499	3	1	96	1	0	0	0	0	1	0	0	0	10198	1696	59	5	819	5	NAGS	17	42083499	Missense_Mutation	SNP	T	TCGA-CQ-5330-01A-01D-1683-08	11287448	42083499	39111711	58	18541											
LRRC30	339291	broad.mit.edu	37	chr18	7231400	7231400	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctccgggttctccctccCgaggtggggaaactgacccg	6	7	13	15	3	1	1	0	1	1	0	4	3	3	2	4	4	2	2	4	4	1	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr18:7231400C>T	uc010wzk.1	+	1	264	c.264C>T	c.(262-264)CCC>CCT	p.P88P		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	88	LRR 1.									ovary(1)|liver(1)	2						TTCTCCCTCCCGAGGTGGGGA	0.587													9	24					0	0	0	0	T	7231400	T	T	7231400	2	4	96	1	0	0	0	0	0	0	0	1	9035	639	23	1		1	LRRC30	18	7231400	Silent	SNP	C	TCGA-CQ-5330-01A-01D-1683-08		7231400	70845848	59	18542											
DSG1	1828	broad.mit.edu	37	chr18	28934345	28934345	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catcgaaggtgtaggttcccCtgctggctctgtgggttgtt	4	14	14	9	1	1	0	0	0	1	0	3	1	2	0	2	4	1	6	2	4	2	4			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr18:28934345C>T	uc002kwp.2	+	15	2398	c.2186C>T	c.(2185-2187)CCT>CTT	p.P729L	DSG1_uc010xbp.1_Missense_Mutation_p.P88L	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	729	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GTAGGTTCCCCTGCTGGCTCT	0.453													32	54					0	0	0	0	T	28934345	T	T	28934345	3	4	96	1	0	0	0	0	1	0	0	0	4798	681	24	4	2244	4	DSG1	18	28934345	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	21702945	28934345	49142903	60	18543											
C18orf54	162681	broad.mit.edu	37	chr18	51892104	51892104	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagcaaatctcctgttccCgttaactctgatgatagtcc	9	15	6	11	1	2	2	0	2	2	0	5	2	4	2	3	0	2	3	3	0	4	5			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr18:51892104C>T	uc002lfn.3	+	5	872	c.756C>T	c.(754-756)CCC>CCT	p.P252P	C18orf54_uc002lfo.3_Silent_p.P413P	NM_173529	NP_775800	Q8IYD9	CR054_HUMAN	hypothetical protein LOC162681 precursor	252						extracellular region				ovary(1)|skin(1)	2				Colorectal(16;0.0206)|READ - Rectum adenocarcinoma(59;0.186)		CTCCTGTTCCCGTTAACTCTG	0.333													39	120					0	0	0	0	T	51892104	T	T	51892104	2	4	96	1	0	0	0	0	0	0	0	1	1913	639	23	1		1	C18orf54	18	51892104	Silent	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	22957759	51892104	26185144	61	18544											
TSHZ1	10194	broad.mit.edu	37	chr18	72999367	72999367	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agaagagctccctggccaagGctgcgtcccccatagcaaaa	12	5	10	14	1	0	2	0	0	0	2	2	2	2	2	4	2	3	3	4	2	5	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr18:72999367G>A	uc002lly.2	+	2	2433	c.1870G>A	c.(1870-1872)GCT>ACT	p.A624T		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	669						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CCTGGCCAAGGCTGCGTCCCC	0.572													14	31					0	0	0	0	A	72999367	A	A	72999367	3	1	96	1	0	0	0	0	1	0	0	0	16690	1203	42	4	1872	4	TSHZ1	18	72999367	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	21107263	72999367	5077881	62	18545											
MUC16	94025	broad.mit.edu	37	chr19	9010979	9010979	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgaatactcactgctggtgGgggccacagagctccgatgg	8	9	14	10	1	1	2	1	1	0	1	2	3	2	2	2	4	3	2	2	4	2	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:9010979G>T	uc002mkp.2	-	37	39143	c.38939C>A	c.(38938-38940)CCC>CAC	p.P12980H	MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACTGCTGGTGGGGGCCACAGA	0.517													25	66					6.12954e-19	7.13911e-19	1	0	T	9010979	T	T	9010979	3	4	96	1	0	0	0	0	1	0	0	0	10026	1232	43	4	4776	4	MUC16	19	9010979	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08		9010979	50118004	63	18546											
ILF3	3609	broad.mit.edu	37	chr19	10791116	10791116	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagatatcacacagagtgcGcaggtatagtcatcgccatt	13	9	10	9	2	2	2	2	0	0	2	3	3	2	2	1	1	1	2	1	1	4	4	rs150021624	byFrequency	TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:10791116G>A	uc002mpn.2	+	9	1271	c.954G>A	c.(952-954)GCG>GCA	p.A318A	ILF3_uc002mpm.2_Silent_p.A318A|ILF3_uc002mpl.2_Silent_p.A318A|ILF3_uc002mpk.2_Silent_p.A318A|ILF3_uc010xli.1_Intron|ILF3_uc002mpo.2_Silent_p.A318A|ILF3_uc002mpp.2_Silent_p.A139A	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	318	DZF.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CACAGAGTGCGCAGGTATAGT	0.507													5	33					0	0	0	0	A	10791116	A	A	10791116	2	1	96	1	0	0	0	0	0	0	0	1	7751	1074	38	1		1	ILF3	19	10791116	Silent	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	1780137	10791116	48337867	64	18547											
ZNF208	7757	broad.mit.edu	37	chr19	22157207	22157207	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taagggttgaggaccagttaAaagctttgccaccttcttca	11	12	9	9	0	2	1	1	1	1	0	2	2	2	2	3	2	2	3	3	2	3	6			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:22157207A>G	uc002nqp.2	-	4	778	c.629T>C	c.(628-630)TTT>TCT	p.F210S	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGACCAGTTAAAAGCTTTGCC	0.368													18	49					0	0	0	0	G	22157207	G	G	22157207	3	3	96	1	0	0	0	0	1	0	0	0	17833	14	1	5	3217	5	ZNF208	19	22157207	Missense_Mutation	SNP	A	TCGA-CQ-5330-01A-01D-1683-08	11366091	22157207	36971776	65	18548											
GGN	199720	broad.mit.edu	37	chr19	38877088	38877088	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaagaggccgccgcctcCgccgccccccagcgaagctt	8	3	11	19	5	0	1	0	0	0	1	1	2	1	1	8	1	3	2	8	1	2	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:38877088C>T	uc002oij.1	-	3	949	c.814G>A	c.(814-816)GGA>AGA	p.G272R	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Missense_Mutation_p.G189R	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	272	Interaction with GGNBP1 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCGCCGCCTCCGCCGCCCCCC	0.647													8	41					0	0	0	0	T	38877088	T	T	38877088	3	4	96	1	0	0	0	0	1	0	0	0	6395	661	23	1	1152	1	GGN	19	38877088	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	16719881	38877088	20251895	66	18549											
PPP5C	5536	broad.mit.edu	37	chr19	46879819	46879819	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaagaaactgcaccggaaAtgtgcctaccaggtaatgca	15	6	10	10	1	0	2	0	0	0	2	0	3	0	3	3	2	5	3	3	2	5	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:46879819A>G	uc002pem.2	+	4	681	c.621A>G	c.(619-621)AAA>AAG	p.K207K	PPP5C_uc010xya.1_Silent_p.K74K|PPP5C_uc002pen.2_Silent_p.K207K	NM_006247	NP_006238	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	207	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		TGCACCGGAAATGTGCCTACC	0.547													10	25					0	0	0	0	G	46879819	G	G	46879819	2	3	96	1	0	0	0	0	0	0	0	1	12466	98	4	5		5	PPP5C	19	46879819	Silent	SNP	A	TCGA-CQ-5330-01A-01D-1683-08	8002731	46879819	12249164	67	18550											
ZNF616	90317	broad.mit.edu	37	chr19	52619805	52619805	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctctgtagtatgtatcctCtgatgattaataaggctgga	10	16	9	6	0	2	2	0	2	2	0	4	3	3	3	1	2	0	4	1	2	5	6			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:52619805C>T	uc002pym.2	-	4	895	c.612G>A	c.(610-612)CAG>CAA	p.Q204Q	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	204	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TATGTATCCTCTGATGATTAA	0.393													42	93					0	0	0	0	T	52619805	T	T	52619805	2	4	96	1	0	0	0	0	0	0	0	1	18108	912	32	2		2	ZNF616	19	52619805	Silent	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	5739986	52619805	6509178	68	18551											
ATRN	8455	broad.mit.edu	37	chr20	3543984	3543984	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatggcgccaaatgcttctCttcagatttcatggcctatg	8	13	8	12	1	3	1	2	0	1	1	4	1	3	1	3	2	1	1	3	2	2	4			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr20:3543984C>T	uc002wim.2	+	10	1850	c.1760C>T	c.(1759-1761)TCT>TTT	p.S587F	ATRN_uc002wil.2_Missense_Mutation_p.S587F	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	587	Extracellular (Potential).|Kelch 5.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						AAATGCTTCTCTTCAGATTTC	0.428													9	163					0	0	0	0	T	3543984	T	T	3543984	3	4	96	1	0	0	0	0	1	0	0	0	1208	913	32	2	1798	2	ATRN	20	3543984	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08		3543984	59481536	69	18552											
ZNF335	63925	broad.mit.edu	37	chr20	44581029	44581029	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagctctgggagtcccctacGcagtgggtcttggctggaga	6	9	16	10	1	2	1	0	0	2	1	3	4	3	2	2	4	2	3	2	4	1	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr20:44581029G>A	uc002xqw.2	-	20	3069	c.2946C>T	c.(2944-2946)TGC>TGT	p.C982C	ZNF335_uc002xqv.2_Silent_p.C94C|ZNF335_uc010zxk.1_Silent_p.C827C	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	982					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				AGTCCCCTACGCAGTGGGTCT	0.662													20	39					0	0	0	0	A	44581029	A	A	44581029	2	1	96	1	0	0	0	0	0	0	0	1	17919	1079	38	1		1	ZNF335	20	44581029	Silent	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	41037045	44581029	18444491	70	18553											
TSSK2	23617	broad.mit.edu	37	chr22	19119046	19119046	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctgtcaagatcatcgaccGcaagaaaacacctactgact	14	7	8	12	2	2	3	2	1	0	2	3	4	2	3	2	1	2	2	2	1	5	1			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr22:19119046G>A	uc002zow.2	+	1	726	c.134G>A	c.(133-135)CGC>CAC	p.R45H	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	45	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					ATCATCGACCGCAAGAAAACA	0.488													3	31					0	0	0	0	A	19119046	A	A	19119046	3	1	96	1	0	0	0	0	1	0	0	0	16736	1087	38	1	136	1	TSSK2	22	19119046	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08		19119046	32185520	71	18554											
SUV39H1	6839	broad.mit.edu	37	chrX	48558589	48558589	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcctcaagcagttccacaaGgacttagaaagggagctgct	13	8	10	10	0	1	1	1	0	0	1	3	3	3	3	2	2	3	4	2	2	4	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:48558589G>A	uc004dkn.2	+	3	318	c.273G>A	c.(271-273)AAG>AAA	p.K91K	SUV39H1_uc011mmf.1_Silent_p.K102K|SUV39H1_uc011mmg.1_RNA	NM_003173	NP_003164	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1	91	Chromo.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding				0						AGTTCCACAAGGACTTAGAAA	0.567													3	9					0	0	0	0	A	48558589	A	A	48558589	2	1	96	1	0	0	0	0	0	0	0	1	15478	991	35	4		4	SUV39H1	23	48558589	Silent	SNP	G	TCGA-CQ-5330-01A-01D-1683-08		48558589	106711971	72	18555											
HUWE1	10075	broad.mit.edu	37	chrX	53562382	53562384	+	In_Frame_Del	DEL	CTT	-	-																															cataccaggtgtacatactcCttcttattctcctctgttac																										TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:53562382_53562384delCTT	uc004dsp.2	-	81	13012_13014	c.12610_12612delAAG	c.(12610-12612)AAGdel	p.K4204del	HUWE1_uc004dsn.2_In_Frame_Del_p.K3012del	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4204	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity	p.K4094del(1)		ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GTACATACTCCTTCTTATTCTCC	0.438													---	---	---								-	53562384	-	-	53562382	7	5	96	1	0	1	0	1	0	0	0	0	7500	680	24	0	528	0	HUWE1	23	53562382	In_Frame_Del	DEL	CTT	TCGA-CQ-5330-01A-01D-1683-08	5003793	53562382	101708178	73	18556											
ZNF711	7552	broad.mit.edu	37	chrX	84523345	84523345	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtatgaagattgtcaagcatCaggtaagagagcattgtata	15	11	11	4	0	2	3	2	1	0	2	2	4	2	3	0	1	2	5	0	1	6	6			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:84523345C>T	uc004eeo.2	+	7	1309	c.962C>T	c.(961-963)TCA>TTA	p.S321L	ZNF711_uc004eep.2_Missense_Mutation_p.S321L|ZNF711_uc004eeq.2_Missense_Mutation_p.S367L|ZNF711_uc011mqy.1_5'UTR	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	321					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						TGTCAAGCATCAGGTAAGAGA	0.303													14	26					0	0	0	0	T	84523345	T	T	84523345	3	4	96	1	0	0	0	0	1	0	0	0	18183	838	29	2	980	2	ZNF711	23	84523345	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	30960963	84523345	70747215	74	18557											
ZBTB33	10009	broad.mit.edu	37	chrX	119388776	119388776	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtattgtatgcaaaaggtcAtatgtctgtctgacaagctt	11	15	9	6	0	3	1	1	1	2	0	3	1	3	1	0	1	2	4	0	1	6	5			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:119388776A>G	uc004esn.1	+	2	1734	c.1506A>G	c.(1504-1506)TCA>TCG	p.S502S	ZBTB33_uc010nqm.1_Silent_p.S502S	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	502	Interaction with CTNND1 (By similarity).|C2H2-type 1.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						GCAAAAGGTCATATGTCTGTC	0.383													12	115					0	0	0	0	G	119388776	G	G	119388776	2	3	96	1	0	0	0	0	0	0	0	1	17603	204	8	5		5	ZBTB33	23	119388776	Silent	SNP	A	TCGA-CQ-5330-01A-01D-1683-08	34865431	119388776	35881784	75	18558											
MST4	51765	broad.mit.edu	37	chrX	131205199	131205199	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atcgttttaagagatggaagGcagaaggacacagtgatgat	15	9	13	4	1	0	4	0	2	0	2	1	7	0	6	0	3	0	2	0	3	3	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:131205199G>A	uc004ewk.1	+	8	1187	c.886G>A	c.(886-888)GCA>ACA	p.A296T	MST4_uc004ewl.1_Missense_Mutation_p.A219T|MST4_uc011mux.1_Missense_Mutation_p.A318T|MST4_uc010nrj.1_Missense_Mutation_p.A296T|MST4_uc004ewm.1_Missense_Mutation_p.A234T	NM_016542	NP_057626	Q9P289	MST4_HUMAN	serine/threonine protein kinase MST4 isoform 1	296					cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(3)|stomach(2)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(192;0.000127)					GAGATGGAAGGCAGAAGGACA	0.328													35	97					0	0	0	0	A	131205199	A	A	131205199	3	1	96	1	0	0	0	0	1	0	0	0	9945	1203	42	4	912	4	MST4	23	131205199	Missense_Mutation	SNP	G	TCGA-CQ-5330-01A-01D-1683-08	11816423	131205199	24065361	76	18559											
FGF13	2258	broad.mit.edu	37	chrX	137791006	137791006	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgctgtcctcatctttggtgCcatcaatggttccatccgcc	5	14	8	14	1	3	0	2	0	1	0	6	0	6	0	5	2	2	2	5	2	1	2			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:137791006C>T	uc004fam.2	-	2	934	c.272G>A	c.(271-273)GGC>GAC	p.G91D	FGF13_uc004fan.2_Missense_Mutation_p.G38D|FGF13_uc011mwi.1_Missense_Mutation_p.G72D|FGF13_uc004faq.2_Missense_Mutation_p.G101D|FGF13_uc004far.2_Missense_Mutation_p.G72D|FGF13_uc011mwj.1_Missense_Mutation_p.G101D|FGF13_uc011mwk.1_Missense_Mutation_p.G45D	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	91					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					ATCTTTGGTGCCATCAATGGT	0.393													38	167					0	0	0	0	T	137791006	T	T	137791006	3	4	96	1	0	0	0	0	1	0	0	0	5874	739	26	4	481	4	FGF13	23	137791006	Missense_Mutation	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	6585807	137791006	17479554	77	18560											
PLXNA3	55558	broad.mit.edu	37	chrX	153696765	153696765	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttctccatgcgcgaccgCggcaccgtggcctcgctcac	5	7	11	18	6	2	0	1	0	1	0	4	1	2	0	4	2	2	3	4	2	0	1	rs140160422	byFrequency	TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:153696765C>T	uc004flm.2	+	23	4256	c.4083C>T	c.(4081-4083)CGC>CGT	p.R1361R		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1361	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGCGCGACCGCGGCACCGTGG	0.667													9	24					0	0	0	0	T	153696765	T	T	153696765	2	4	96	1	0	0	0	0	0	0	0	1	12176	755	27	1		1	PLXNA3	23	153696765	Silent	SNP	C	TCGA-CQ-5330-01A-01D-1683-08	15905759	153696765	1573795	78	18561											
PLOD1	5351	broad.mit.edu	37	chr1	12012751	12012751	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccaggacagcgacagcgatCagctgttttacaccaagatc	12	7	10	12	2	1	1	1	0	0	1	2	4	1	2	2	1	4	2	2	1	2	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:12012751C>G	uc001atm.2	+	5	629	c.538C>G	c.(538-540)CAG>GAG	p.Q180E	PLOD1_uc010obb.1_Missense_Mutation_p.Q227E	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	180					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	CGACAGCGATCAGCTGTTTTA	0.617													9	69					0	0	0	0	G	12012751	G	G	12012751	3	3	97	1	0	0	0	0	1	0	0	0	12156	827	29	2	556	2	PLOD1	1	12012751	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		12012751	237237870	1	18562											
GRIK3	2899	broad.mit.edu	37	chr1	37324810	37324810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgcccgctggtagcacaCggacacgatatggacggcgt	8	7	15	11	5	0	0	0	0	0	0	0	3	0	2	1	5	2	3	1	5	2	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:37324810C>T	uc001caz.2	-	7	1138	c.1003G>A	c.(1003-1005)GTG>ATG	p.V335M	GRIK3_uc001cba.1_Missense_Mutation_p.V335M	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	335	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGGTAGCACACGGACACGATA	0.622													11	112					0	0	0	0	T	37324810	T	T	37324810	3	4	97	1	0	0	0	0	1	0	0	0	6814	536	19	1	1796	1	GRIK3	1	37324810	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	25312059	37324810	211925811	2	18563											
LEPR	3953	broad.mit.edu	37	chr1	66102651	66102651	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattccaaacttgttctactCagactcataagatcatggaa	15	12	5	9	0	4	2	3	0	1	2	5	3	5	3	1	1	2	1	1	1	5	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:66102651C>T	uc001dci.2	+	20	3653	c.3451C>T	c.(3451-3453)CAG>TAG	p.Q1151*	LEPR_uc009waq.2_3'UTR	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	1151	Cytoplasmic (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TTGTTCTACTCAGACTCATAA	0.338													5	91					0	0	0	0	T	66102651	T	T	66102651	4	4	97	1	0	0	0	0	0	1	0	0	8768	827	29	2	3751	2	LEPR	1	66102651	Nonsense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	28777841	66102651	183147970	3	18564											
CHI3L2	1117	broad.mit.edu	37	chr1	111778658	111778658	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactttagagatctggatttCatcaacctcctgtcctttga	9	15	6	11	0	3	2	2	1	1	1	5	4	5	3	3	1	1	0	3	1	2	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:111778658C>T	uc001eam.2	+	7	689	c.618C>T	c.(616-618)TTC>TTT	p.F206F	CHI3L2_uc001ean.2_Silent_p.F196F|CHI3L2_uc001eao.2_Silent_p.F127F|CHI3L2_uc009wga.2_Silent_p.F127F	NM_004000	NP_003991	Q15782	CH3L2_HUMAN	chitinase 3-like 2 isoform a	206					chitin catabolic process	extracellular space	cation binding|chitinase activity			central_nervous_system(1)	1		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		ATCTGGATTTCATCAACCTCC	0.473													49	269					0	0	0	0	T	111778658	T	T	111778658	2	4	97	1	0	0	0	0	0	0	0	1	3356	825	29	2		2	CHI3L2	1	111778658	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	45676007	111778658	137471963	4	18565											
ZNF697	90874	broad.mit.edu	37	chr1	120168657	120168657	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcctcagagtcctcaaaatCagaacccatccctttgtctt	10	12	5	14	0	4	2	3	0	1	2	7	2	7	2	4	0	1	0	4	0	3	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:120168657C>G	uc001ehy.1	-	2	181	c.67G>C	c.(67-69)GAT>CAT	p.D23H		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	23					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		TCCTCAAAATCAGAACCCATC	0.498													23	209					0	0	0	0	G	120168657	G	G	120168657	3	3	97	1	0	0	0	0	1	0	0	0	18167	826	29	2	1578	2	ZNF697	1	120168657	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	8389999	120168657	129081964	5	18566											
S100A8	6279	broad.mit.edu	37	chr1	153362715	153362715	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaaccagacgtctgcacccTttttctgtcaagattgagga	10	12	9	10	1	3	4	1	2	2	2	3	5	3	5	2	1	2	1	2	1	2	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:153362715T>C	uc001fbs.2	-	3	201	c.146A>G	c.(145-147)AAG>AGG	p.K49R		NM_002964	NP_002955	P05109	S10A8_HUMAN	S100 calcium-binding protein A8	49	EF-hand 2.				chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCTGCACCCTTTTTCTGTCA	0.507													3	151					0	0	0	0	C	153362715	C	C	153362715	3	2	97	1	0	0	0	0	1	0	0	0	13851	1609	56	5	139	5	S100A8	1	153362715	Missense_Mutation	SNP	T	TCGA-CQ-5331-01A-02D-1870-08	33194058	153362715	95887906	6	18567											
MTX1	4580	broad.mit.edu	37	chr1	155178627	155178627	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggacccccccgcagtccccGctcggggacgagccccaagg	6	2	14	19	4	0	0	0	0	0	0	2	3	1	2	7	4	1	2	7	4	1	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:155178627G>A	uc001fjb.2	+	1	138	c.32G>A	c.(31-33)CGC>CAC	p.R11H	RAG1AP1_uc010pey.1_Intron|THBS3_uc001fix.2_5'Flank|THBS3_uc009wqi.2_5'Flank|THBS3_uc001fiz.2_5'Flank|THBS3_uc001fiy.2_5'Flank|THBS3_uc010pfu.1_5'Flank|THBS3_uc010pfv.1_5'Flank|THBS3_uc001fja.2_Intron|THBS3_uc009wqj.1_Intron|MTX1_uc001fjc.2_Missense_Mutation_p.R11H	NM_002455	NP_002446	Q13505	MTX1_HUMAN	metaxin 1 isoform 1	11					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	protein binding			skin(1)	1	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CGCAGTCCCCGCTCGGGGACG	0.647													3	20					0	0	0	0	A	155178627	A	A	155178627	3	1	97	1	0	0	0	0	1	0	0	0	10020	1087	38	1	34	1	MTX1	1	155178627	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	1815912	155178627	94071994	7	18568											
PCP4L1	654790	broad.mit.edu	37	chr1	161254169	161254169	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggcggaggaggaggaggaGattgacattgatctgacagc	13	6	17	5	1	1	4	0	3	1	1	1	9	1	8	0	6	1	0	0	6	1	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:161254169G>A	uc001gad.2	+	3	353	c.105G>A	c.(103-105)GAG>GAA	p.E35E		NM_001102566	NP_001096036	A6NKN8	PC4L1_HUMAN	Purkinje cell protein 4 like 1	35											0	all_cancers(52;4.16e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGGAGGAGGAGATTGACATTG	0.488													9	93					0	0	0	0	A	161254169	A	A	161254169	2	1	97	1	0	0	0	0	0	0	0	1	11653	933	33	2		2	PCP4L1	1	161254169	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	6075542	161254169	87996452	8	18569											
CACNA1S	779	broad.mit.edu	37	chr1	201047194	201047194	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtacatcttcatcagcatctCagtggtgaagagggacagca	12	9	11	9	0	4	2	3	1	2	1	5	3	4	3	0	2	3	3	0	2	2	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:201047194C>T	uc001gvv.2	-	11	1659	c.1432G>A	c.(1432-1434)GAG>AAG	p.E478K		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	478	Helical; Name=S2 of repeat II; (Potential).|II.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATCAGCATCTCAGTGGTGAAG	0.567													22	100					0	0	0	0	T	201047194	T	T	201047194	3	4	97	1	0	0	0	0	1	0	0	0	2559	835	29	2	4325	2	CACNA1S	1	201047194	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	39793025	201047194	48203427	9	18570											
C1orf107	27042	broad.mit.edu	37	chr1	210012455	210012455	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtatttgtgggcaatattGatgaccacttcaggattggt	9	14	11	7	1	1	2	1	2	0	0	1	3	1	3	2	3	0	2	2	3	3	6			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:210012455G>A	uc001hhr.1	+	7	1340	c.1264G>A	c.(1264-1266)GAT>AAT	p.D422N	C1orf107_uc009xcu.1_Missense_Mutation_p.D137N	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	422					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		GGGCAATATTGATGACCACTT	0.428													11	87					0	0	0	0	A	210012455	A	A	210012455	3	1	97	1	0	0	0	0	1	0	0	0	1990	1290	45	2	1290	2	C1orf107	1	210012455	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	8965261	210012455	39238166	10	18571											
CAPN2	824	broad.mit.edu	37	chr1	223957578	223957578	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctggggctgaaggagttCtacattctctggacgaagat	11	10	13	7	1	2	2	0	1	2	1	3	5	2	4	0	4	2	3	0	4	4	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:223957578C>G	uc001hob.3	+	17	2015	c.1791C>G	c.(1789-1791)TTC>TTG	p.F597L	CAPN2_uc010puy.1_Missense_Mutation_p.F519L|CAPN2_uc001hoc.2_Missense_Mutation_p.F178L	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	597	Domain IV.|EF-hand 1.				proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		TGAAGGAGTTCTACATTCTCT	0.478													2	5					0	0	0	0	G	223957578	G	G	223957578	3	3	97	1	0	0	0	0	1	0	0	0	2639	912	32	2	1864	2	CAPN2	1	223957578	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	13945123	223957578	25293043	11	18572											
OBSCN	84033	broad.mit.edu	37	chr1	228433261	228433261	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaagctgagctccagctCaaaagtacgcatggaggtca	14	6	12	9	1	2	2	2	1	0	1	3	4	3	3	1	2	4	5	1	2	5	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:228433261C>G	uc009xez.1	+	12	3673	c.3629C>G	c.(3628-3630)TCA>TGA	p.S1210*	OBSCN_uc001hsn.2_Nonsense_Mutation_p.S1210*	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1210	Poly-Ser.|Ig-like 12.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGCTCCAGCTCAAAAGTACGC	0.627													16	102					0	0	0	0	G	228433261	G	G	228433261	4	3	97	1	0	0	0	0	0	1	0	0	10866	838	29	2	3671	2	OBSCN	1	228433261	Nonsense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	4475683	228433261	20817360	12	18573											
TARBP1	6894	broad.mit.edu	37	chr1	234529206	234529206	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaacgagcactgaagcccCaaatacctcacaggtcctgc	14	5	7	15	1	1	1	1	1	0	0	2	2	2	1	4	1	6	1	4	1	5	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:234529206C>A	uc001hwd.2	-	28	4462	c.4462G>T	c.(4462-4464)GGG>TGG	p.G1488W		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	1488					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			ACTGAAGCCCCAAATACCTCA	0.498													14	74					4.36969e-10	4.89314e-10	1	0	A	234529206	A	A	234529206	3	1	97	1	0	0	0	0	1	0	0	0	15621	594	21	4	415	4	TARBP1	1	234529206	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	6095945	234529206	14721415	13	18574											
RGS7	6000	broad.mit.edu	37	chr1	241261998	241261998	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taggtatcttggaaagaaagCttttgaccgtacgaatagga	14	11	11	5	2	1	2	0	1	1	1	1	5	1	4	1	3	2	3	1	3	7	7			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr1:241261998C>A	uc001hyv.2	-	3	473	c.143G>T	c.(142-144)AGC>ATC	p.S48I	RGS7_uc010pyh.1_Missense_Mutation_p.S22I|RGS7_uc010pyj.1_5'UTR|RGS7_uc001hyu.2_Missense_Mutation_p.S48I|RGS7_uc009xgn.1_Missense_Mutation_p.S48I|RGS7_uc001hyw.2_Missense_Mutation_p.S48I	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	48	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GGAAAGAAAGCTTTTGACCGT	0.363													10	51					1.08611e-07	1.17343e-07	1	0	A	241261998	A	A	241261998	3	1	97	1	0	0	0	0	1	0	0	0	13375	797	28	4	1384	4	RGS7	1	241261998	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	6732792	241261998	7988623	14	18575											
FAM179A	165186	broad.mit.edu	37	chr2	29240094	29240094	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaggagatggagctgcttcgGaggctggaggagcccaggac	10	5	18	8	1	0	1	0	0	0	1	1	7	0	6	1	7	3	3	1	7	1	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:29240094G>A	uc010ezl.2	+	9	1470	c.1119G>A	c.(1117-1119)CGG>CGA	p.R373R	FAM179A_uc010ymm.1_Silent_p.R373R|FAM179A_uc002rmr.3_Intron	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	373							binding			ovary(3)|skin(1)	4						AGCTGCTTCGGAGGCTGGAGG	0.577													14	76					0	0	0	0	A	29240094	A	A	29240094	2	1	97	1	0	0	0	0	0	0	0	1	5533	1161	41	2		2	FAM179A	2	29240094	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08		29240094	213959279	15	18576											
SOCS5	9655	broad.mit.edu	37	chr2	46986940	46986940	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagcttccgccgctacaacaGatccctgcatgcccgaattg	9	8	9	15	3	0	1	0	0	0	1	2	3	2	1	4	0	5	3	4	0	3	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:46986940G>C	uc002rvf.2	+	2	1435	c.1271G>C	c.(1270-1272)AGA>ACA	p.R424T	SOCS5_uc010yoe.1_Missense_Mutation_p.R393T|SOCS5_uc002rvg.2_Missense_Mutation_p.R424T	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	424	SH2.				cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CGCTACAACAGATCCCTGCAT	0.517													16	94					0	0	0	0	C	46986940	C	C	46986940	3	2	97	1	0	0	0	0	1	0	0	0	14981	942	33	2	1273	2	SOCS5	2	46986940	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	17746846	46986940	196212433	16	18577											
PDCL3	79031	broad.mit.edu	37	chr2	101188255	101188255	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcggcatgaacctgacaaGagatggtaagggctctggga	11	7	16	7	1	1	3	0	2	1	1	1	5	1	4	1	5	1	3	1	5	3	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:101188255G>C	uc002tao.2	+	5	684	c.572G>C	c.(571-573)AGA>ACA	p.R191T		NM_024065	NP_076970	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	191					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding				0						AACCTGACAAGAGATGGTAAG	0.502													30	162					0	0	0	0	C	101188255	C	C	101188255	3	2	97	1	0	0	0	0	1	0	0	0	11682	942	33	2	590	2	PDCL3	2	101188255	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	54201315	101188255	142011118	17	18578											
POTEE	445582	broad.mit.edu	37	chr2	132021797	132021797	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgctatgttgccctggacttCgagcaggagatggccacggc	7	9	14	11	2	0	1	0	0	0	1	1	4	0	2	2	4	3	3	2	4	1	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:132021797C>G	uc002tsn.2	+	15	2821	c.2769C>G	c.(2767-2769)TTC>TTG	p.F923L	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Missense_Mutation_p.F523L|POTEE_uc002tsl.2_Missense_Mutation_p.F505L|POTEE_uc010fmy.1_Missense_Mutation_p.F387L	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	923	Actin-like.						ATP binding				0						CCCTGGACTTCGAGCAGGAGA	0.597													17	383					0	0	0	0	G	132021797	G	G	132021797	3	3	97	1	0	0	0	0	1	0	0	0	12319	883	31	3	2827	3	POTEE	2	132021797	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	30833542	132021797	111177576	18	18579											
GPR39	2863	broad.mit.edu	37	chr2	133174980	133174980	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgaggcctgcagctacgctaCgctgctgcacgtgctgacac	7	7	12	15	4	0	1	0	1	0	0	0	2	0	1	1	1	7	7	1	1	2	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:133174980C>T	uc002ttl.2	+	1	834	c.365C>T	c.(364-366)ACG>ATG	p.T122M		NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	122	Helical; Name=3; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						AGCTACGCTACGCTGCTGCAC	0.572													17	61					0	0	0	0	T	133174980	T	T	133174980	3	4	97	1	0	0	0	0	1	0	0	0	6731	536	19	1	367	1	GPR39	2	133174980	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	1153183	133174980	110024393	19	18580											
NEB	4703	broad.mit.edu	37	chr2	152383461	152383461	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattaaagtattcctgagggCgagcaccgtgtttttgtcat	9	15	10	7	2	1	1	1	1	0	0	2	2	2	1	2	1	1	3	2	1	4	6			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:152383461C>A	uc010fnx.2	-	120	17004	c.16813G>T	c.(16813-16815)GCC>TCC	p.A5605S	NEB_uc002txr.2_Missense_Mutation_p.A2028S|NEB_uc002txt.3_Missense_Mutation_p.A110S	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5605	Nebulin 153.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCCTGAGGGCGAGCACCGTG	0.463													4	20					4.096e-09	4.5161e-09	1	0	A	152383461	A	A	152383461	3	1	97	1	0	0	0	0	1	0	0	0	10356	768	27	3	3801	3	NEB	2	152383461	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	19208481	152383461	90815912	20	18581											
TTN	7273	broad.mit.edu	37	chr2	179529384	179529384	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccagcaagatataccttCatcaggaaggacttcaggct	12	10	8	11	0	3	1	3	0	0	1	4	3	4	3	2	3	2	2	2	3	4	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:179529384C>A	uc010zfk.1	-	12	1185	c.637G>T	c.(637-639)GAA>TAA	p.E213*	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATATACCTTCATCAGGAAGG	0.378													11	69					4.68919e-08	5.11764e-08	1	0	A	179529384	A	A	179529384	4	1	97	1	0	0	0	0	0	1	0	0	16803	841	29	2		2	TTN	2	179529384	Nonsense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	27145923	179529384	63669989	21	18582											
TTN	7273	broad.mit.edu	37	chr2	179611406	179611406	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttttgaatgttagaaatttCcagtgaacacacattaccca	14	14	5	8	0	0	3	0	2	0	1	1	3	1	3	2	0	2	1	2	0	5	5	rs147119153		TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:179611406C>G	uc002unb.2	-	46	15945	c.15721G>C	c.(15721-15723)GAA>CAA	p.E5241Q	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	8760							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E5241K(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAGAAATTTCCAGTGAACAC	0.393													10	155					0	0	0	0	G	179611406	G	G	179611406	3	3	97	1	0	0	0	0	1	0	0	0	16803	864	30	2	94576	2	TTN	2	179611406	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	82022	179611406	63587967	22	18583											
TTN	7273	broad.mit.edu	37	chr2	179611715	179611715	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgtaccgtcttccctttCtatttttgatggatatgttt	5	21	8	7	1	2	1	0	1	2	0	3	2	3	2	2	2	1	2	2	2	3	8			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:179611715C>T	uc002unb.2	-	46	15636	c.15412G>A	c.(15412-15414)GAA>AAA	p.E5138K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	1039							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCCCTTTCTATTTTTGAT	0.443													36	141					0	0	0	0	T	179611715	T	T	179611715	3	4	97	1	0	0	0	0	1	0	0	0	16803	922	32	2	94885	2	TTN	2	179611715	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	309	179611715	63587658	23	18584											
AOX1	316	broad.mit.edu	37	chr2	201485524	201485524	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttttgtgactagttcaaGagctcatgctaagattgtgt	10	15	10	6	0	2	3	2	1	0	2	2	4	2	3	0	0	2	3	0	0	3	6			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:201485524G>C	uc002uvx.2	+	17	1957	c.1856G>C	c.(1855-1857)AGA>ACA	p.R619T	AOX1_uc010zhf.1_Missense_Mutation_p.R175T|AOX1_uc010fsu.2_Intron	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	619					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	ACTAGTTCAAGAGCTCATGCT	0.423													9	35					0	0	0	0	C	201485524	C	C	201485524	3	2	97	1	0	0	0	0	1	0	0	0	729	942	33	2	1922	2	AOX1	2	201485524	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	21873809	201485524	41713849	24	18585											
CASP8	841	broad.mit.edu	37	chr2	202131505	202131505	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaggcagggctcaaatttCtgcctacaggtgggtggaaa	11	8	13	9	0	2	0	1	0	1	0	2	1	2	1	2	5	2	2	2	5	3	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:202131505C>T	uc002uxr.1	+	3	505	c.296C>T	c.(295-297)TCT>TTT	p.S99F	CASP8_uc010ftc.1_Missense_Mutation_p.S99F|CASP8_uc002uxo.1_Missense_Mutation_p.S99F|CASP8_uc002uxp.1_Missense_Mutation_p.S99F|CASP8_uc002uxq.1_Missense_Mutation_p.S99F|CASP8_uc002uxs.1_Missense_Mutation_p.S99F|CASP8_uc002uxt.1_Missense_Mutation_p.S158F|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.S99F|CASP8_uc002uxw.1_Missense_Mutation_p.S99F|CASP8_uc002uxy.1_Missense_Mutation_p.S99F|CASP8_uc002uxx.1_Missense_Mutation_p.S99F|CASP8_uc010ftf.2_Missense_Mutation_p.S99F	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	99					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GCTCAAATTTCTGCCTACAGG	0.493										HNSCC(4;0.00038)			5	42					0	0	0	0	T	202131505	T	T	202131505	3	4	97	1	0	0	0	0	1	0	0	0	2689	913	32	2	479	2	CASP8	2	202131505	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	645981	202131505	41067868	25	18586											
ARPC2	10109	broad.mit.edu	37	chr2	219082227	219082227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtgaacaaccgcatcatcGaggagacgctcgcgctcaag	12	5	12	12	5	2	2	2	1	0	1	4	4	2	2	1	2	2	3	1	2	3	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:219082227G>A	uc002vhd.2	+	2	146	c.34G>A	c.(34-36)GAG>AAG	p.E12K	ARPC2_uc002vhe.2_Missense_Mutation_p.E12K	NM_152862	NP_690601	O15144	ARPC2_HUMAN	actin related protein 2/3 complex subunit 2	12					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		CCGCATCATCGAGGAGACGCT	0.473													6	36					0	0	0	0	A	219082227	A	A	219082227	3	1	97	1	0	0	0	0	1	0	0	0	973	1059	37	1	36	1	ARPC2	2	219082227	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	16950722	219082227	24117146	26	18587											
NMUR1	10316	broad.mit.edu	37	chr2	232392867	232392867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacttgtctccggccccgatCgtgctgctggagcctgcagg	4	9	13	15	3	1	0	0	0	1	0	3	2	1	1	4	3	4	3	4	3	0	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr2:232392867C>T	uc002vry.3	-	2	975	c.865G>A	c.(865-867)GAT>AAT	p.D289N		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	289	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CGGCCCCGATCGTGCTGCTGG	0.652													11	74					0	0	0	0	T	232392867	T	T	232392867	3	4	97	1	0	0	0	0	1	0	0	0	10560	884	31	1	423	1	NMUR1	2	232392867	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	13310640	232392867	10806506	27	18588											
CLEC3B	7123	broad.mit.edu	37	chr3	45077267	45077267	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaccggcgcccgcatcgccTacaagaactgggagactgag	10	5	13	13	4	0	4	0	2	0	2	1	5	0	4	3	2	2	1	3	2	3	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:45077267T>C	uc003cok.3	+	3	556	c.460T>C	c.(460-462)TAC>CAC	p.Y154H	CLEC3B_uc003col.2_Missense_Mutation_p.Y112H	NM_003278	NP_003269	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	154	C-type lectin.				skeletal system development	extracellular space	protein binding|sugar binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCGCATCGCCTACAAGAACTG	0.667													3	73					0	0	0	0	C	45077267	C	C	45077267	3	2	97	1	0	0	0	0	1	0	0	0	3526	1522	53	5	470	5	CLEC3B	3	45077267	Missense_Mutation	SNP	T	TCGA-CQ-5331-01A-02D-1870-08		45077267	152945163	28	18589											
MST1R	4486	broad.mit.edu	37	chr3	49927421	49927421	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccaggaagtgggtaaggtCaaaagggtcaatgtggcggt	11	7	18	5	1	2	0	2	0	0	0	2	1	2	1	1	7	0	1	1	7	5	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:49927421C>T	uc003cxy.3	-	19	4147	c.3883G>A	c.(3883-3885)GAC>AAC	p.D1295N	MST1R_uc011bdc.1_Missense_Mutation_p.D174N	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1295	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGGGTAAGGTCAAAAGGGTCA	0.532													11	83					0	0	0	0	T	49927421	T	T	49927421	3	4	97	1	0	0	0	0	1	0	0	0	9944	826	29	2	327	2	MST1R	3	49927421	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	4850154	49927421	148095009	29	18590											
DNAH1	25981	broad.mit.edu	37	chr3	52394093	52394093	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccagtggatctcacagctGaggtgaggacatggggggcg	8	8	17	8	1	1	2	1	2	1	0	3	4	2	4	1	6	1	1	1	6	0	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:52394093G>A	uc011bef.1	+	27	4830	c.4569G>A	c.(4567-4569)CTG>CTA	p.L1523L		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1523	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCTCACAGCTGAGGTGAGGAC	0.562													20	93					0	0	0	0	A	52394093	A	A	52394093	2	1	97	1	0	0	0	0	0	0	0	1	4619	1277	45	2		2	DNAH1	3	52394093	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	2466672	52394093	145628337	30	18591											
CCDC66	285331	broad.mit.edu	37	chr3	56605280	56605280	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgatccttggaaaaaatctGaaagtgataaaataatatgg	19	11	8	3	0	1	3	0	3	1	0	2	4	2	4	1	2	0	0	1	2	8	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:56605280G>A	uc003dhz.2	+	7	973	c.886G>A	c.(886-888)GAA>AAA	p.E296K	CCDC66_uc003dhy.2_5'UTR|CCDC66_uc003dhu.2_Missense_Mutation_p.E262K|CCDC66_uc003dhx.2_RNA	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	296										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		GAAAAAATCTGAAAGTGATAA	0.269													15	89					0	0	0	0	A	56605280	A	A	56605280	3	1	97	1	0	0	0	0	1	0	0	0	2851	1291	45	2	912	2	CCDC66	3	56605280	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	4211187	56605280	141417150	31	18592											
ROBO2	6092	broad.mit.edu	37	chr3	77666886	77666886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggctcacctggatgagttGacaagagcctatcagtttga	11	10	11	9	0	2	4	2	3	0	1	2	5	2	5	2	2	1	3	2	2	2	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:77666886G>C	uc003dpy.3	+	22	4159	c.3516G>C	c.(3514-3516)TTG>TTC	p.L1172F	ROBO2_uc003dpz.2_Missense_Mutation_p.L1176F|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.L1176F|ROBO2_uc003dqa.2_Missense_Mutation_p.L299F	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1172	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TGGATGAGTTGACAAGAGCCT	0.433													10	65					0	0	0	0	C	77666886	C	C	77666886	3	2	97	1	0	0	0	0	1	0	0	0	13579	1281	45	2	3604	2	ROBO2	3	77666886	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	21061606	77666886	120355544	32	18593											
ROBO1	6091	broad.mit.edu	37	chr3	78656171	78656171	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgactttatagcaggtggcgGcacaggaggtggtggaagat	10	9	17	5	1	0	2	0	1	0	1	0	4	0	4	0	7	1	2	0	7	3	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:78656171G>A	uc003dqe.2	-	29	4664	c.4456C>T	c.(4456-4458)CCG>TCG	p.P1486S	ROBO1_uc003dqb.2_Missense_Mutation_p.P1447S|ROBO1_uc003dqc.2_Missense_Mutation_p.P1386S|ROBO1_uc003dqd.2_Missense_Mutation_p.P1441S|ROBO1_uc010hoh.2_Missense_Mutation_p.P678S|ROBO1_uc011bgl.1_Missense_Mutation_p.P1058S	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1486	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GCAGGTGGCGGCACAGGAGGT	0.423													4	75					0	0	0	0	A	78656171	A	A	78656171	3	1	97	1	0	0	0	0	1	0	0	0	13578	1203	42	4	511	4	ROBO1	3	78656171	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	989285	78656171	119366259	33	18594											
DRD3	1814	broad.mit.edu	37	chr3	113850003	113850003	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgggttgccttcttctccCgaagtggcactccccgaggt	4	13	11	13	2	2	0	0	0	2	0	4	2	3	0	4	3	1	2	4	3	1	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:113850003C>A	uc003ebd.2	-	7	1391	c.968G>T	c.(967-969)CGG>CTG	p.R323L	DRD3_uc010hqn.1_Missense_Mutation_p.R323L|DRD3_uc003ebb.1_Missense_Mutation_p.R290L|DRD3_uc003ebc.1_Missense_Mutation_p.R323L	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	323	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	CTTCTTCTCCCGAAGTGGCAC	0.403													22	109					7.41877e-09	8.13794e-09	1	0	A	113850003	A	A	113850003	3	1	97	1	0	0	0	0	1	0	0	0	4780	652	23	3	242	3	DRD3	3	113850003	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	35193832	113850003	84172427	34	18595											
ACPP	55	broad.mit.edu	37	chr3	132047150	132047150	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaagtcccattgacacctttCccactgaccccataaaggaa	13	8	6	14	0	0	2	0	2	0	0	2	4	2	3	5	1	0	0	5	1	4	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:132047150C>A	uc010htp.2	+	2	250	c.160C>A	c.(160-162)CCC>ACC	p.P54T	ACPP_uc003eon.3_Missense_Mutation_p.P54T|ACPP_uc003eop.3_Missense_Mutation_p.P54T	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	54						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						TGACACCTTTCCCACTGACCC	0.443													7	80					1.26484e-09	1.40176e-09	1	0	A	132047150	A	A	132047150	3	1	97	1	0	0	0	0	1	0	0	0	167	855	30	2	166	2	ACPP	3	132047150	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	18197147	132047150	65975280	35	18596											
GPR149	344758	broad.mit.edu	37	chr3	154146734	154146734	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctggtagttggagtggagtCtcggcggctcctccgaacac	6	9	14	12	3	1	0	0	0	1	0	4	3	3	2	3	5	1	3	3	5	2	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:154146734C>T	uc003faa.2	-	1	771	c.671G>A	c.(670-672)AGA>AAA	p.R224K		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	224	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GGAGTGGAGTCTCGGCGGCTC	0.577													10	84					0	0	0	0	T	154146734	T	T	154146734	3	4	97	1	0	0	0	0	1	0	0	0	6692	913	32	2	1540	2	GPR149	3	154146734	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	22099584	154146734	43875696	36	18597											
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	17	7	10	7	0	1	2	1	2	0	0	1	4	1	3	0	3	3	2	0	3	5	0	rs121913279		TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			7	53					0	0	0	0	G	178952085	G	G	178952085	3	3	97	1	0	0	0	0	1	0	0	0	11968	217	8	5	3218	5	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-CQ-5331-01A-02D-1870-08	24805351	178952085	19070345	37	18598											
GP5	2814	broad.mit.edu	37	chr3	194118459	194118459	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaagcaaccccttgggcaGgtgggtcaggttgtttcccg	6	10	13	12	1	1	0	1	0	0	0	3	0	3	0	4	4	2	4	4	4	2	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr3:194118459G>T	uc003ftv.1	-	2	584	c.553C>A	c.(553-555)CTG>ATG	p.L185M		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	185	Extracellular (Potential).|LRR 5.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		CCCTTGGGCAGGTGGGTCAGG	0.542													19	83					9.7654e-05	0.000102418	1	0	T	194118459	T	T	194118459	3	4	97	1	0	0	0	0	1	0	0	0	6621	991	35	4	1133	4	GP5	3	194118459	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	15166374	194118459	3903971	38	18599											
ZNF141	7700	broad.mit.edu	37	chr4	337651	337651	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaccctgaccagcagaatttGtatagagatgtgatgttgga	12	11	12	6	0	0	4	0	2	0	2	0	7	0	5	2	1	1	3	2	1	3	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr4:337651G>A	uc003gaa.2	+	3	262	c.84G>A	c.(82-84)TTG>TTA	p.L28L	ZNF141_uc003fzz.2_Silent_p.L28L|ZNF141_uc003gab.2_Silent_p.L28L	NM_003441	NP_003432	Q15928	ZN141_HUMAN	zinc finger protein 141	28	KRAB.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0						AGCAGAATTTGTATAGAGATG	0.388													4	145					0	0	0	0	A	337651	A	A	337651	2	1	97	1	0	0	0	0	0	0	0	1	17797	1368	48	4		4	ZNF141	4	337651	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08		337651	190816625	39	18600											
WHSC2	7469	broad.mit.edu	37	chr4	1985396	1985396	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgttggccgtcttgaacatCtcctgggcagcgaacatctg	7	12	11	11	2	3	1	0	1	3	0	4	2	3	1	2	2	3	2	2	2	2	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr4:1985396C>G	uc003gem.2	-	10	1602	c.1362G>C	c.(1360-1362)GAG>GAC	p.E454D	WHSC2_uc003gek.2_Missense_Mutation_p.E180D|WHSC2_uc003gel.2_Missense_Mutation_p.E368D|WHSC2_uc003gen.2_Missense_Mutation_p.E308D	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	443					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)			TCTTGAACATCTCCTGGGCAG	0.657													12	61					0	0	0	0	G	1985396	G	G	1985396	3	3	97	1	0	0	0	0	1	0	0	0	17432	912	32	2	265	2	WHSC2	4	1985396	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	1647745	1985396	189168880	40	18601											
WHSC2	7469	broad.mit.edu	37	chr4	1985419	1985419	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgggcagcgaacatctgctCtctctacagcggggagaggg	8	7	15	11	2	3	1	0	0	3	1	4	3	3	1	0	4	5	2	0	4	2	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr4:1985419C>G	uc003gem.2	-	10	1579	c.1339G>C	c.(1339-1341)GAG>CAG	p.E447Q	WHSC2_uc003gek.2_Missense_Mutation_p.E173Q|WHSC2_uc003gel.2_Missense_Mutation_p.E361Q|WHSC2_uc003gen.2_Missense_Mutation_p.E301Q	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	436					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)			AACATCTGCTCTCTCTACAGC	0.667													8	47					0	0	0	0	G	1985419	G	G	1985419	3	3	97	1	0	0	0	0	1	0	0	0	17432	922	32	2	288	2	WHSC2	4	1985419	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	23	1985419	189168857	41	18602											
DCAF16	54876	broad.mit.edu	37	chr4	17805653	17805653	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcaccatagagtcctcttCttcagaggaatcccactctt	9	11	8	13	0	4	2	1	0	3	2	6	3	6	3	3	2	0	1	3	2	2	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr4:17805653C>T	uc003gpn.2	-	3	1173	c.112G>A	c.(112-114)GAA>AAA	p.E38K	DCAF16_uc003gpo.2_RNA	NM_017741	NP_060211	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	38						CUL4 RING ubiquitin ligase complex				ovary(1)	1						GAGTCCTCTTCTTCAGAGGAA	0.423													13	103					0	0	0	0	T	17805653	T	T	17805653	3	4	97	1	0	0	0	0	1	0	0	0	4285	922	32	2	542	2	DCAF16	4	17805653	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	15820234	17805653	173348623	42	18603											
CWH43	80157	broad.mit.edu	37	chr4	49052833	49052833	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaagtggtcatagaccacaGagaagtttctgagaaaattc	16	9	10	6	0	2	3	1	1	1	3	3	6	2	3	1	1	0	1	1	1	5	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr4:49052833G>C	uc003gyv.2	+	15	2170	c.1988G>C	c.(1987-1989)AGA>ACA	p.R663T	CWH43_uc011bzl.1_Missense_Mutation_p.R636T	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	663					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						ATAGACCACAGAGAAGTTTCT	0.398													5	51					0	0	0	0	C	49052833	C	C	49052833	3	2	97	1	0	0	0	0	1	0	0	0	4090	942	33	2	2046	2	CWH43	4	49052833	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	31247180	49052833	142101443	43	18604											
SCLT1	132320	broad.mit.edu	37	chr4	129857913	129857913	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgctaggagatgcctcagttCaacaatggaatttctattac	12	12	8	9	1	3	1	2	0	1	1	3	3	3	2	1	2	3	2	1	2	6	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr4:129857913C>G	uc003igp.2	-	18	2232	c.1726G>C	c.(1726-1728)GAA>CAA	p.E576Q	SCLT1_uc003ign.2_Missense_Mutation_p.E240Q|SCLT1_uc003igo.2_Missense_Mutation_p.E186Q|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	576	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						TGCCTCAGTTCAACAATGGAA	0.363													7	35					0	0	0	0	G	129857913	G	G	129857913	3	3	97	1	0	0	0	0	1	0	0	0	13971	835	29	2	356	2	SCLT1	4	129857913	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	80805080	129857913	61296363	44	18605											
MARCH11	441061	broad.mit.edu	37	chr5	16067874	16067874	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcgcttaaacactctgtaAactgcagctccttcatgaac	12	10	6	13	1	2	1	1	1	1	0	3	1	3	1	1	0	6	4	1	0	5	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:16067874A>T	uc003jfo.2	-	4	1128	c.915T>A	c.(913-915)GTT>GTA	p.V305V	MARCH11_uc010itw.1_Silent_p.V61V	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	305						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						ACACTCTGTAAACTGCAGCTC	0.408													6	46					0	0	0	0	T	16067874	T	T	16067874	2	4	97	1	0	0	0	0	0	0	0	1	9353	1	1	5		5	MARCH11	5	16067874	Silent	SNP	A	TCGA-CQ-5331-01A-02D-1870-08		16067874	164847386	45	18606											
MGC42105	167359	broad.mit.edu	37	chr5	43246074	43246074	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggtggtgagggagatcaCgctggggaaacggataggct	11	6	19	5	2	1	2	1	1	0	1	1	6	1	4	0	7	1	2	0	7	3	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:43246074C>T	uc003jno.2	+	2	1078	c.197C>T	c.(196-198)ACG>ATG	p.T66M		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	66							ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						AGGGAGATCACGCTGGGGAAA	0.552													14	102					0	0	0	0	T	43246074	T	T	43246074	3	4	97	1	0	0	0	0	1	0	0	0	9605	536	19	1	199	1	MGC42105	5	43246074	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	27178200	43246074	137669186	46	18607											
CWC27	10283	broad.mit.edu	37	chr5	64267529	64267529	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatattctactattctttaGaggaagaagcccctccagat	14	12	6	9	0	2	3	0	0	2	3	3	4	3	4	3	1	2	0	3	1	7	7			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:64267529G>C	uc003jtn.1	+	12	1262	c.1043_splice	c.e12-1	p.E348_splice	CWC27_uc010iwt.1_Splice_Site_p.E348_splice	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10						protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						CTATTCTTTAGAGGAAGAAGC	0.418													7	92					0	0	0	0	C	64267529	C	C	64267529	5	2	97	1	0	0	0	0	0	0	1	0	4087	956	33	2	1088	2	CWC27	5	64267529	Splice_Site	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	21021455	64267529	116647731	47	18608											
MARVELD2	153562	broad.mit.edu	37	chr5	68715437	68715437	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagctatagcgccagatctCaaaccagtaaggcgctttgt	11	9	9	12	2	1	1	1	0	1	1	2	1	1	1	3	1	3	3	3	1	4	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:68715437C>G	uc003jwq.2	+	2	284	c.225C>G	c.(223-225)CTC>CTG	p.L75L	MARVELD2_uc010ixf.2_Silent_p.L75L|MARVELD2_uc003jwr.1_Silent_p.L75L|MARVELD2_uc003jws.1_RNA	NM_001038603	NP_001033692	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2 isoform 1	75	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane|tight junction					0		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		CGCCAGATCTCAAACCAGTAA	0.522													9	66					0	0	0	0	G	68715437	G	G	68715437	2	3	97	1	0	0	0	0	0	0	0	1	9371	813	29	2		2	MARVELD2	5	68715437	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	4447908	68715437	112199823	48	18609											
ZNF366	167465	broad.mit.edu	37	chr5	71757020	71757020	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccgtggtttttgttctcctCtgagtggagggcgagggtga	4	13	17	7	2	2	2	0	2	2	0	3	4	2	3	2	4	0	2	2	4	0	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:71757020C>G	uc003kce.1	-	2	490	c.304G>C	c.(304-306)GAG>CAG	p.E102Q		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		TTGTTCTCCTCTGAGTGGAGG	0.582													54	232					0	0	0	0	G	71757020	G	G	71757020	3	3	97	1	0	0	0	0	1	0	0	0	17937	922	32	2	1946	2	ZNF366	5	71757020	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	3041583	71757020	109158240	49	18610											
KIF3A	11127	broad.mit.edu	37	chr5	132051521	132051521	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagcatcctttggatcttCattaattctagctttatttt	10	19	4	8	0	3	0	1	0	2	0	4	1	4	1	1	1	2	2	1	1	4	9			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:132051521C>G	uc003kxo.2	-	8	1211	c.1057G>C	c.(1057-1059)GAA>CAA	p.E353Q	KIF3A_uc003kxn.2_Missense_Mutation_p.E312Q|KIF3A_uc011cxf.1_Missense_Mutation_p.E353Q|KIF3A_uc003kxp.2_Missense_Mutation_p.E353Q	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	353					blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTTGGATCTTCATTAATTCTA	0.333													9	48					0	0	0	0	G	132051521	G	G	132051521	3	3	97	1	0	0	0	0	1	0	0	0	8339	835	29	2	1082	2	KIF3A	5	132051521	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	60294501	132051521	48863739	50	18611											
PCDHA10	56139	broad.mit.edu	37	chr5	140237074	140237074	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacggtgtctgcgtgggacGcggacgcgcaggagaacgcc	7	5	17	12	7	2	1	1	0	1	1	2	4	2	3	1	4	2	1	1	4	1	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:140237074G>A	uc003lhx.2	+	1	1441	c.1441G>A	c.(1441-1443)GCG>ACG	p.A481T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.A481T|PCDHA10_uc011dad.1_Missense_Mutation_p.A481T	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	481	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGTGGGACGCGGACGCGCA	0.662													24	142					0	0	0	0	A	140237074	A	A	140237074	3	1	97	1	0	0	0	0	1	0	0	0	11574	1087	38	1	1443	1	PCDHA10	5	140237074	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	8185553	140237074	40678186	51	18612											
SH3TC2	79628	broad.mit.edu	37	chr5	148427536	148427536	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggagcggctctttacacaGaaggagagtgtcaggtctta	10	10	13	8	1	3	2	1	0	2	2	3	4	3	3	0	4	2	1	0	4	3	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:148427536G>A	uc003lpu.2	-	3	320	c.168C>T	c.(166-168)TTC>TTT	p.F56F	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Silent_p.F56F|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_5'UTR|SH3TC2_uc003lpw.1_Silent_p.F56F	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	56							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTTACACAGAAGGAGAGTG	0.502													20	171					0	0	0	0	A	148427536	A	A	148427536	2	1	97	1	0	0	0	0	0	0	0	1	14327	933	33	2		2	SH3TC2	5	148427536	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	8190462	148427536	32487724	52	18613											
C5orf41	153222	broad.mit.edu	37	chr5	172550143	172550143	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaaaccgggtacagaatcCaagagatgagagaggaccca	16	5	12	8	1	0	4	0	1	0	3	1	7	1	5	3	2	2	2	3	2	5	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:172550143C>T	uc003mch.2	+	8	2046	c.1742C>T	c.(1741-1743)CCA>CTA	p.P581L	C5orf41_uc011dfd.1_Missense_Mutation_p.P581L	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	581							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GTACAGAATCCAAGAGATGAG	0.363													14	103					0	0	0	0	T	172550143	T	T	172550143	3	4	97	1	0	0	0	0	1	0	0	0	2310	594	21	4	1800	4	C5orf41	5	172550143	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	24122607	172550143	8365117	53	18614											
ZNF354A	6940	broad.mit.edu	37	chr5	178152447	178152447	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttgctgcaacagggagatCacttttggtttggtaaatgg	9	13	12	7	0	1	1	1	0	0	1	1	2	1	1	1	4	3	4	1	4	3	5	rs146853988	by1000genomes	TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:178152447C>T	uc003mjj.2	-	4	384	c.186G>A	c.(184-186)GTG>GTA	p.V62V		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	62	KRAB.				regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		ACAGGGAGATCACTTTTGGTT	0.468													15	113					0	0	0	0	T	178152447	T	T	178152447	2	4	97	1	0	0	0	0	0	0	0	1	17931	813	29	2		2	ZNF354A	5	178152447	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	5602304	178152447	2762813	54	18615											
ADAMTS2	9509	broad.mit.edu	37	chr5	178563011	178563011	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccacctccccggtctcccTggactcgcagtacaggtggc	6	7	10	18	2	1	0	0	0	1	0	4	1	2	1	5	4	1	2	5	4	1	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr5:178563011T>C	uc003mjw.2	-	13	1984	c.1984A>G	c.(1984-1986)AGG>GGG	p.R662G		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	662	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCGGTCTCCCTGGACTCGCAG	0.632													5	144					0	0	0	0	C	178563011	C	C	178563011	3	2	97	1	0	0	0	0	1	0	0	0	265	1579	55	5	1691	5	ADAMTS2	5	178563011	Missense_Mutation	SNP	T	TCGA-CQ-5331-01A-02D-1870-08	410564	178563011	2352249	55	18616											
HSPA1L	3305	broad.mit.edu	37	chr6	31779660	31779660	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgccctggtcgttggcgatGatctccaccttgccgtgctg	3	13	12	13	3	1	1	0	1	1	0	3	2	1	1	4	2	3	2	4	2	0	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:31779660G>A	uc003nxh.2	-	2	273	c.90C>T	c.(88-90)ATC>ATT	p.I30I	HSPA1L_uc010jte.2_Silent_p.I30I	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	30					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						CGTTGGCGATGATCTCCACCT	0.607													8	120					0	0	0	0	A	31779660	A	A	31779660	2	1	97	1	0	0	0	0	0	0	0	1	7449	1280	45	2		2	HSPA1L	6	31779660	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08		31779660	139335407	56	18617											
CYP21A2	1589	broad.mit.edu	37	chr6	31975160	31975160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggaagggcacttgcacatgGctgcagtggacctcctgatc	8	9	13	11	0	0	1	0	1	0	0	2	3	1	3	2	4	2	4	2	4	1	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:31975160G>A	uc010jtp.2	+	8	971	c.853G>A	c.(853-855)GCT>ACT	p.A285T	CYP21A2_uc011dpb.1_Missense_Mutation_p.A255T			P08686	CP21A_HUMAN	SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2; SubName: Full=Cytochrome P450 21-hydroxylase; SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_b; SubName: Full=DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B)); SubName: Full=cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNA;	284					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						CTTGCACATGGCTGCAGTGGA	0.607													35	187					0	0	0	0	A	31975160	A	A	31975160	3	1	97	1	0	0	0	0	1	0	0	0	4170	1203	42	4	871	4	CYP21A2	6	31975160	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	195500	31975160	139139907	57	18618											
ZNF318	24149	broad.mit.edu	37	chr6	43323487	43323487	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcctcatcttcaatgtcggGaaagctacgtcgcctttttt	7	15	7	12	3	3	0	2	0	1	0	6	1	4	1	2	1	2	1	2	1	3	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:43323487G>A	uc003oux.2	-	4	1663	c.1585C>T	c.(1585-1587)CCC>TCC	p.P529S	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	529					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TCAATGTCGGGAAAGCTACGT	0.488													87	334					0	0	0	0	A	43323487	A	A	43323487	3	1	97	1	0	0	0	0	1	0	0	0	17903	1174	41	2	5282	2	ZNF318	6	43323487	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	11348327	43323487	127791580	58	18619											
TFAP2D	83741	broad.mit.edu	37	chr6	50740385	50740385	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actcatggctttgggactccGgcaatatgtgcagctctaag	9	11	11	10	1	2	0	1	0	1	0	3	1	3	1	1	3	2	4	1	3	3	3	rs149503577		TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:50740385G>A	uc003paf.2	+	8	1679	c.1167G>A	c.(1165-1167)CCG>CCA	p.P389P	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	389	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity	p.P389L(1)		ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					TTGGGACTCCGGCAATATGTG	0.428													12	69					0	0	0	0	A	50740385	A	A	50740385	2	1	97	1	0	0	0	0	0	0	0	1	15856	1103	39	1		1	TFAP2D	6	50740385	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	7416898	50740385	120374682	59	18620											
PKHD1	5314	broad.mit.edu	37	chr6	51612823	51612823	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgaattcctaagcacaatCtgcacttttttgacggaatt	12	14	6	9	1	1	2	0	2	1	0	2	3	2	3	1	1	2	2	1	1	4	6			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:51612823C>G	uc003pah.1	-	58	9867	c.9591G>C	c.(9589-9591)CAG>CAC	p.Q3197H	PKHD1_uc010jzn.1_Missense_Mutation_p.Q1180H|PKHD1_uc003pai.2_Missense_Mutation_p.Q3197H	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3197	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TAAGCACAATCTGCACTTTTT	0.423													27	164					0	0	0	0	G	51612823	G	G	51612823	3	3	97	1	0	0	0	0	1	0	0	0	12026	912	32	2	2712	2	PKHD1	6	51612823	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	872438	51612823	119502244	60	18621											
PKHD1	5314	broad.mit.edu	37	chr6	51934279	51934279	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtgtctggtataggaaaaGatcctgtttagcactgatca	11	13	11	6	0	2	2	1	1	1	1	3	3	3	3	1	2	1	3	1	2	5	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:51934279G>C	uc003pah.1	-	11	1030	c.754C>G	c.(754-756)CTT>GTT	p.L252V	PKHD1_uc003pai.2_Missense_Mutation_p.L252V	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	252	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TATAGGAAAAGATCCTGTTTA	0.453													42	247					0	0	0	0	C	51934279	C	C	51934279	3	2	97	1	0	0	0	0	1	0	0	0	12026	942	33	2	11737	2	PKHD1	6	51934279	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	321456	51934279	119180788	61	18622											
MCM3	4172	broad.mit.edu	37	chr6	52129419	52129419	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatgccctcagacaccatGacctgattgtcatcctgcat	10	11	7	13	0	2	4	2	3	0	1	3	4	3	4	4	0	2	1	4	0	0	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:52129419G>T	uc003pan.1	-	17	2504	c.2394C>A	c.(2392-2394)GTC>GTA	p.V798V	MCM3_uc011dwu.1_Silent_p.V752V	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	798					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					CAGACACCATGACCTGATTGT	0.532													11	139					0.000978159	0.00101596	1	0	T	52129419	T	T	52129419	2	4	97	1	0	0	0	0	0	0	0	1	9440	1277	45	2		2	MCM3	6	52129419	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	195140	52129419	118985648	62	18623											
SYNCRIP	10492	broad.mit.edu	37	chr6	86346765	86346765	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	attgagaccagtgagtggatCcatcattagacgaagatccc	13	9	10	9	1	1	4	1	2	0	3	3	7	3	5	3	1	0	0	3	1	2	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:86346765C>G	uc003pla.2	-	6	1127	c.586G>C	c.(586-588)GAT>CAT	p.D196H	SYNCRIP_uc003pku.2_Missense_Mutation_p.D196H|SYNCRIP_uc003pkw.2_Missense_Mutation_p.D196H|SYNCRIP_uc003pky.2_Missense_Mutation_p.D98H|SYNCRIP_uc003pkv.2_Missense_Mutation_p.D196H|SYNCRIP_uc003pkx.2_Missense_Mutation_p.D44H|SYNCRIP_uc003pkz.2_Missense_Mutation_p.D196H	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	196	RRM 1.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		GTGAGTGGATCCATCATTAGA	0.403													9	69					0	0	0	0	G	86346765	G	G	86346765	3	3	97	1	0	0	0	0	1	0	0	0	15510	855	30	2	1355	2	SYNCRIP	6	86346765	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	34217346	86346765	84768302	63	18624											
BACH2	60468	broad.mit.edu	37	chr6	90660199	90660199	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcgaggaggagaactcacaGagagggaggctgcagggtga	12	3	20	6	1	1	3	1	1	0	2	1	8	1	5	0	6	2	2	0	6	1	0	rs142894061	by1000genomes	TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:90660199G>C	uc011eab.1	-	7	2435	c.1626C>G	c.(1624-1626)CTC>CTG	p.L542L	BACH2_uc003pnw.2_Silent_p.L542L|BACH2_uc010kch.2_Silent_p.L542L	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	542						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		AGAACTCACAGAGAGGGAGGC	0.607													26	55					0	0	0	0	C	90660199	C	C	90660199	2	2	97	1	0	0	0	0	0	0	0	1	1286	929	33	2		2	BACH2	6	90660199	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	4313434	90660199	80454868	64	18625											
KIAA1919	91749	broad.mit.edu	37	chr6	111587118	111587118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggctatttggggggacaaagGagccccacatatgcaggcct	10	7	14	10	0	0	0	0	0	0	0	0	2	0	2	3	6	2	2	3	6	3	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:111587118G>A	uc003puv.3	+	4	775	c.353G>A	c.(352-354)GGA>GAA	p.G118E		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	118	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		GGGGACAAAGGAGCCCCACAT	0.433													27	70					0	0	0	0	A	111587118	A	A	111587118	3	1	97	1	0	0	0	0	1	0	0	0	8301	1174	41	2	367	2	KIAA1919	6	111587118	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	20926919	111587118	59527949	65	18626											
UTRN	7402	broad.mit.edu	37	chr6	144780337	144780337	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacaaatcttcttggccttCaccccaaaattgaaatggct	12	12	6	11	0	3	2	1	2	2	0	3	2	3	2	3	2	0	1	3	2	4	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr6:144780337C>T	uc003qkt.2	+	20	2646	c.2554C>T	c.(2554-2556)CAC>TAC	p.H852Y	UTRN_uc010khq.1_Missense_Mutation_p.H852Y	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	852	Interaction with SYNM.|Spectrin 6.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TCTTGGCCTTCACCCCAAAAT	0.507													4	54					0	0	0	0	T	144780337	T	T	144780337	3	4	97	1	0	0	0	0	1	0	0	0	17171	826	29	2	2632	2	UTRN	6	144780337	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	33193219	144780337	26334730	66	18627											
C1GALT1	56913	broad.mit.edu	37	chr7	7278194	7278194	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgacacgtatgtcatactaGacaatttgaggtggcttctt	11	14	9	7	1	2	3	1	2	1	1	2	3	2	3	0	2	1	2	0	2	4	6			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr7:7278194G>C	uc010ktn.2	+	3	752	c.529G>C	c.(529-531)GAC>CAC	p.D177H	C1GALT1_uc003sra.2_Missense_Mutation_p.D177H|C1GALT1_uc010kto.1_Missense_Mutation_p.D177H	NM_020156	NP_064541	Q9NS00	C1GLT_HUMAN	core 1 synthase,	177	Lumenal (Potential).				angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		TGTCATACTAGACAATTTGAG	0.368													8	69					0	0	0	0	C	7278194	C	C	7278194	3	2	97	1	0	0	0	0	1	0	0	0	1961	942	33	2	535	2	C1GALT1	7	7278194	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08		7278194	151860469	67	18628											
DNAH11	8701	broad.mit.edu	37	chr7	21939660	21939660	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataaaacgcgcttgactgctGatgttaccaaaaaaacaaag	18	8	7	8	2	0	2	0	2	0	0	0	2	0	2	1	0	4	3	1	0	7	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr7:21939660G>A	uc003svc.2	+	82	13277	c.13246G>A	c.(13246-13248)GAT>AAT	p.D4416N		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4416					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTTGACTGCTGATGTTACCAA	0.448									Kartagener_syndrome				13	48					0	0	0	0	A	21939660	A	A	21939660	3	1	97	1	0	0	0	0	1	0	0	0	4621	1290	45	2	13569	2	DNAH11	7	21939660	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	14661466	21939660	137199003	68	18629											
ZNF735	730291	broad.mit.edu	37	chr7	63680190	63680190	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagcctttaggtggccctCaaaccttactagacataaga	14	9	7	11	0	1	2	1	0	0	2	1	2	1	2	3	2	3	0	3	2	6	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr7:63680190C>G	uc011kdn.1	+	4	761	c.761C>G	c.(760-762)TCA>TGA	p.S254*		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	254	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGTGGCCCTCAAACCTTACT	0.453													4	17					0	0	0	0	G	63680190	G	G	63680190	4	3	97	1	0	0	0	0	0	1	0	0	18191	838	29	2	775	2	ZNF735	7	63680190	Nonsense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	41740530	63680190	95458473	69	18630											
ABCB1	5243	broad.mit.edu	37	chr7	87148696	87148696	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccaagtaggctccaaacCggaaacatccagcataggaa	16	4	8	13	1	0	0	0	0	0	0	2	2	2	2	5	3	3	3	5	3	6	2	rs144369247		TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr7:87148696C>T	uc003uiz.1	-	24	3291	c.2873G>A	c.(2872-2874)CGG>CAG	p.R958Q	ABCB1_uc011khc.1_Missense_Mutation_p.R894Q	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	958	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GGCTCCAAACCGGAAACATCC	0.323													10	60					0	0	0	0	T	87148696	T	T	87148696	3	4	97	1	0	0	0	0	1	0	0	0	40	652	23	1	993	1	ABCB1	7	87148696	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	23468506	87148696	71989967	70	18631											
ADAM22	53616	broad.mit.edu	37	chr7	87782587	87782587	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaactgaatattgaagggaCggagaagggtaactgtggga	15	7	16	3	1	0	3	0	2	0	1	0	7	0	5	0	4	2	1	0	4	6	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr7:87782587C>T	uc003ujn.2	+	21	1812	c.1733C>T	c.(1732-1734)ACG>ATG	p.T578M	ADAM22_uc003ujk.1_Missense_Mutation_p.T578M|ADAM22_uc003ujl.1_Missense_Mutation_p.T578M|ADAM22_uc003ujm.2_Missense_Mutation_p.T578M|ADAM22_uc003ujo.2_Missense_Mutation_p.T578M|ADAM22_uc003ujp.1_Missense_Mutation_p.T630M	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	578	Cys-rich.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			ATTGAAGGGACGGAGAAGGGT	0.433													6	46					0	0	0	0	T	87782587	T	T	87782587	3	4	97	1	0	0	0	0	1	0	0	0	244	536	19	1	1815	1	ADAM22	7	87782587	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	633891	87782587	71356076	71	18632											
OR2AE1	81392	broad.mit.edu	37	chr7	99474426	99474426	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtagccatcttcaggatGattgtggagacatgcatcag	10	12	12	7	0	3	2	2	1	1	1	3	4	3	3	1	3	2	2	1	3	1	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr7:99474426G>A	uc003usc.1	-	1	231	c.231C>T	c.(229-231)ATC>ATT	p.I77I		NM_001005276	NP_001005276	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					TCTTCAGGATGATTGTGGAGA	0.483													16	71					0	0	0	0	A	99474426	A	A	99474426	2	1	97	1	0	0	0	0	0	0	0	1	11037	1280	45	2		2	OR2AE1	7	99474426	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	11691839	99474426	59664237	72	18633											
MUC17	140453	broad.mit.edu	37	chr7	100676143	100676143	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgttgactccaaaactcaGgtgaccacttctactgaagc	11	10	7	13	0	2	3	1	3	1	0	3	3	3	3	3	1	3	1	3	1	4	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr7:100676143G>A	uc003uxp.1	+	3	1499	c.1446G>A	c.(1444-1446)CAG>CAA	p.Q482Q	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	482	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|6.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAAAACTCAGGTGACCACTT	0.473													60	407					0	0	0	0	A	100676143	A	A	100676143	2	1	97	1	0	0	0	0	0	0	0	1	10027	991	35	4		4	MUC17	7	100676143	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	1201717	100676143	58462520	73	18634											
SYPL1	6856	broad.mit.edu	37	chr7	105752650	105752650	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgaggttgatctggaagccgGacatcctctgaggaaaggag	11	8	15	7	1	2	3	0	3	2	0	3	7	3	7	2	5	1	1	2	5	2	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr7:105752650G>A	uc003vdp.2	-	2	141	c.59C>T	c.(58-60)TCC>TTC	p.S20F	SYPL1_uc003vdo.2_Missense_Mutation_p.S2F	NM_006754	NP_006745	Q16563	SYPL1_HUMAN	synaptophysin-like 1 isoform a	20	Cytoplasmic (Potential).				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity				0						CTGGAAGCCGGACATCCTCTG	0.557													7	53					0	0	0	0	A	105752650	A	A	105752650	3	1	97	1	0	0	0	0	1	0	0	0	15528	1174	41	2	740	2	SYPL1	7	105752650	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	5076507	105752650	53386013	74	18635											
CNOT4	4850	broad.mit.edu	37	chr7	135098284	135098284	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcctcatcccccaattcatGaagatacatgcagtcaggtt	11	10	7	13	1	3	2	3	1	0	1	4	2	4	2	3	1	2	2	3	1	3	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr7:135098284G>A	uc003vsv.1	-	6	947	c.640C>T	c.(640-642)CAT>TAT	p.H214Y	CNOT4_uc003vss.2_Missense_Mutation_p.H214Y|CNOT4_uc011kpz.1_Missense_Mutation_p.H214Y|CNOT4_uc003vst.2_Missense_Mutation_p.H214Y|CNOT4_uc003vsu.1_Missense_Mutation_p.H214Y|CNOT4_uc011kpy.1_Missense_Mutation_p.H214Y	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	214	C3H1-type.				nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						CCCAATTCATGAAGATACATG	0.408													12	84					0	0	0	0	A	135098284	A	A	135098284	3	1	97	1	0	0	0	0	1	0	0	0	3636	1290	45	2	1408	2	CNOT4	7	135098284	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	29345634	135098284	24040379	75	18636											
ATP6V0A4	50617	broad.mit.edu	37	chr7	138418934	138418934	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	accatctggacaattcccagGatcaccgacatcttcatttt	11	12	5	13	1	4	0	2	0	2	0	5	3	5	2	3	2	0	0	3	2	1	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr7:138418934G>A	uc003vuf.2	-	15	1876	c.1638C>T	c.(1636-1638)ATC>ATT	p.I546I	ATP6V0A4_uc003vug.2_Silent_p.I546I|ATP6V0A4_uc003vuh.2_Silent_p.I546I	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	546	Helical; (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						CAATTCCCAGGATCACCGACA	0.428													7	49					0	0	0	0	A	138418934	A	A	138418934	2	1	97	1	0	0	0	0	0	0	0	1	1172	1164	41	2		2	ATP6V0A4	7	138418934	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	3320650	138418934	20719729	76	18637											
MTMR7	9108	broad.mit.edu	37	chr8	17157648	17157648	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctatgctgttgtctgaggtaGaaaaccctgagtgcttgctg	8	13	12	8	0	1	3	0	2	1	1	1	3	1	3	1	1	4	5	1	1	4	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr8:17157648G>C	uc003wxm.2	-	14	1945	c.1706C>G	c.(1705-1707)TCT>TGT	p.S569C	MTMR7_uc011kya.1_Missense_Mutation_p.S203C|MTMR7_uc011kyb.1_Missense_Mutation_p.S160C	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	569							protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		GTCTGAGGTAGAAAACCCTGA	0.438													25	155					0	0	0	0	C	17157648	C	C	17157648	3	2	97	1	0	0	0	0	1	0	0	0	10001	942	33	2	280	2	MTMR7	8	17157648	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08		17157648	129206374	77	18638											
IDO1	3620	broad.mit.edu	37	chr8	39781060	39781060	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaaggcgctgttggaaataGcttcttgcttggagaaagcc	11	11	12	7	1	1	1	0	0	1	1	1	3	1	2	1	3	3	4	1	3	5	6			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr8:39781060G>C	uc003xnm.2	+	7	724	c.610G>C	c.(610-612)GCT>CCT	p.A204P	IDO1_uc003xnn.2_RNA	NM_002164	NP_002155	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	204					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)	2					L-Tryptophan(DB00150)	GTTGGAAATAGCTTCTTGCTT	0.423													6	45					0	0	0	0	C	39781060	C	C	39781060	3	2	97	1	0	0	0	0	1	0	0	0	7540	971	34	4	636	4	IDO1	8	39781060	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	22623412	39781060	106582962	78	18639											
RB1CC1	9821	broad.mit.edu	37	chr8	53570373	53570373	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatcctgaacagtcagtggTggaggagttctcggtgaggt	8	10	17	6	1	2	2	1	2	1	0	4	5	3	5	1	6	1	1	1	6	1	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr8:53570373T>A	uc003xre.3	-	15	2574	c.2016A>T	c.(2014-2016)CCA>CCT	p.P672P	RB1CC1_uc003xrf.3_Silent_p.P672P	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	672					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CAGTCAGTGGTGGAGGAGTTC	0.443													10	70					0	0	0	0	A	53570373	A	A	53570373	2	1	97	1	0	0	0	0	0	0	0	1	13164	1683	59	5		5	RB1CC1	8	53570373	Silent	SNP	T	TCGA-CQ-5331-01A-02D-1870-08	13789313	53570373	92793649	79	18640											
EYA1	2138	broad.mit.edu	37	chr8	72267089	72267089	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggggccactgggggattCactactaccactcagacggc	8	9	12	12	1	2	1	2	0	0	1	2	2	2	2	2	5	2	0	2	5	2	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr8:72267089C>T	uc003xys.3	-	2	339	c.52G>A	c.(52-54)GAA>AAA	p.E18K	EYA1_uc003xyr.3_Missense_Mutation_p.E18K|EYA1_uc003xyt.3_Intron|EYA1_uc010lzf.2_5'UTR|EYA1_uc003xyu.2_Missense_Mutation_p.E18K|EYA1_uc011lfe.1_Missense_Mutation_p.E18K|EYA1_uc003xyv.2_5'UTR	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	18					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CTGGGGGATTCACTACTACCA	0.453													29	188					0	0	0	0	T	72267089	T	T	72267089	3	4	97	1	0	0	0	0	1	0	0	0	5353	835	29	2	1790	2	EYA1	8	72267089	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	18696716	72267089	74096933	80	18641											
E2F5	1875	broad.mit.edu	37	chr8	86114424	86114424	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaaaaaaggagaatttatGatatcaccaatgtcttagag	17	10	9	5	0	2	3	1	1	1	2	2	4	2	3	1	2	0	1	1	2	8	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr8:86114424G>A	uc003ycz.3	+	2	314	c.277G>A	c.(277-279)GAT>AAT	p.D93N	E2F5_uc003yda.3_Missense_Mutation_p.D93N|E2F5_uc010mab.2_5'UTR	NM_001951	NP_001942	Q15329	E2F5_HUMAN	E2F transcription factor 5 isoform 1	93	Potential.|DEF box.|Leucine-zipper.				G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1						GAGAATTTATGATATCACCAA	0.383													6	35					0	0	0	0	A	86114424	A	A	86114424	3	1	97	1	0	0	0	0	1	0	0	0	4892	1290	45	2	283	2	E2F5	8	86114424	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	13847335	86114424	60249598	81	18642											
FZD6	8323	broad.mit.edu	37	chr8	104336827	104336827	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattttggtgtccaaggcatCttaagacttctgggggacaa	10	12	12	7	0	2	1	0	0	2	1	3	3	3	2	1	4	0	1	1	4	3	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr8:104336827C>G	uc003ylh.2	+	4	777	c.493C>G	c.(493-495)CTT>GTT	p.L165V	FZD6_uc003yli.2_Missense_Mutation_p.L165V|FZD6_uc003ylj.2_Missense_Mutation_p.L165V|FZD6_uc011lhn.1_Missense_Mutation_p.L131V|FZD6_uc011lho.1_Intron|FZD6_uc011lhp.1_Missense_Mutation_p.L110V	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	165	Extracellular (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			TCCAAGGCATCTTAAGACTTC	0.428													22	139					0	0	0	0	G	104336827	G	G	104336827	3	3	97	1	0	0	0	0	1	0	0	0	6168	913	32	2	503	2	FZD6	8	104336827	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	18222403	104336827	42027195	82	18643											
HAS2	3037	broad.mit.edu	37	chr8	122626357	122626358	+	Frame_Shift_Ins	INS	-	AA	AA																															aacatggaagatcatacatcINSaagcaccatgtcatattgtt																										TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr8:122626357_122626358insAA	uc003yph.2	-	4	2188_2189	c.1650_1651insTT	c.(1648-1653)CTTGATfs	p.L550fs		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	550_551	Extracellular (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			GATCATACATCAAGCACCATGT	0.446													---	---	---								AA	122626358	AA	AA	122626357	7	5	97	1	0	1	1	0	0	0	0	0	7001	826	29	0	11	0	HAS2	8	122626357	Frame_Shift_Ins	INS	-	TCGA-CQ-5331-01A-02D-1870-08	18289530	122626357	23737665	83	18644											
TG	7038	broad.mit.edu	37	chr8	133885398	133885398	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcggagggagagtttatGcctgtccagtgcaaatttgt	8	13	13	7	1	1	1	0	0	1	1	2	3	2	2	2	2	3	2	2	2	2	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr8:133885398G>C	uc003ytw.2	+	5	611	c.570G>C	c.(568-570)ATG>ATC	p.M190I		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	190	Thyroglobulin type-1 3.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GAGAGTTTATGCCTGTCCAGT	0.502													8	55					0	0	0	0	C	133885398	C	C	133885398	3	2	97	1	0	0	0	0	1	0	0	0	15879	1319	46	4	588	4	TG	8	133885398	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	11259041	133885398	12478624	84	18645											
CDKN2A	1029	broad.mit.edu	37	chr9	21971029	21971029	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccacgggcagacggcccCaggcatcgcgcacgtccagc	7	3	14	17	5	0	1	0	0	0	1	3	1	2	1	4	4	1	3	4	4	0	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr9:21971029C>T	uc003zpk.2	-	2	541	c.329G>A	c.(328-330)TGG>TAG	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.L165L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGACGGCCCCAGGCATCGCG	0.731		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			5	25					0	0	0	0	T	21971029	T	T	21971029	4	4	97	1	0	0	0	0	0	1	0	0	3176	595	21	4	149	4	CDKN2A	9	21971029	Nonsense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		21971029	119242402	85	18646											
SPAG8	26206	broad.mit.edu	37	chr9	35810671	35810671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcatctccagcatggcttCacgcttccctgtgagagagt	8	10	11	12	1	2	2	1	1	1	1	4	4	3	2	2	1	2	4	2	1	0	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr9:35810671C>T	uc003zye.2	-	4	1163	c.1048G>A	c.(1048-1050)GAA>AAA	p.E350K	SPAG8_uc003zyf.2_Missense_Mutation_p.E267K|SPAG8_uc003zyg.2_Missense_Mutation_p.E350K	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	350						acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			AGCATGGCTTCACGCTTCCCT	0.527													5	48					0	0	0	0	T	35810671	T	T	35810671	3	4	97	1	0	0	0	0	1	0	0	0	15050	835	29	2	676	2	SPAG8	9	35810671	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	13839642	35810671	105402760	86	18647											
PRUNE2	158471	broad.mit.edu	37	chr9	79318700	79318700	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagaagacattttctctgcaGagagaccttttctttcattt	10	17	6	8	0	3	4	1	0	2	4	4	5	3	4	1	0	1	1	1	0	2	7			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr9:79318700G>A	uc010mpk.2	-	9	7953	c.7829C>T	c.(7828-7830)TCT>TTT	p.S2610F	PRUNE2_uc004akj.3_Missense_Mutation_p.S63F|PRUNE2_uc010mpl.1_Missense_Mutation_p.S63F	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2610					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TTTCTCTGCAGAGAGACCTTT	0.453													13	90					0	0	0	0	A	79318700	A	A	79318700	3	1	97	1	0	0	0	0	1	0	0	0	12703	942	33	2	1481	2	PRUNE2	9	79318700	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	43508029	79318700	61894731	87	18648											
TRUB2	26995	broad.mit.edu	37	chr9	131084698	131084698	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaccccatacttgaagatCacagcacccgctggacctgg	11	6	9	15	1	1	3	1	1	0	2	1	4	1	4	4	2	2	2	4	2	2	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr9:131084698C>A	uc004buq.1	-	1	1	c.-9_splice	c.e1-1		COQ4_uc011max.1_5'Flank|COQ4_uc004bur.3_5'Flank|COQ4_uc004bus.2_5'Flank|COQ4_uc010mxy.2_5'Flank	NM_015679	NP_056494	O95900	TRUB2_HUMAN	TruB pseudouridine (psi) synthase homolog 2						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(1)	1						ACTTGAAGATCACAGCACCCG	0.622													13	49					0.000151284	0.000157894	1	0	A	131084698	A	A	131084698	5	1	97	1	0	0	0	0	0	0	1	0	16670	841	29	2		2	TRUB2	9	131084698	Splice_Site	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	51765998	131084698	10128733	88	18649											
EDF1	8721	broad.mit.edu	37	chr9	139757370	139757370	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acactcaccaatggcccgctCgattttgccaagcacctggt	9	9	8	15	2	1	0	1	0	0	0	2	1	1	0	4	2	2	2	4	2	2	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr9:139757370C>G	uc004cjt.1	-	4	401	c.373G>C	c.(373-375)GAG>CAG	p.E125Q	EDF1_uc004cju.1_Missense_Mutation_p.E125Q	NM_003792	NP_003783	O60869	EDF1_HUMAN	endothelial differentiation-related factor 1	125	HTH cro/C1-type.				endothelial cell differentiation|multicellular organismal development|positive regulation of DNA binding|positive regulation of transcription, DNA-dependent|regulation of lipid metabolic process|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleolus|nucleus	calmodulin binding|protein binding|protein binding|sequence-specific DNA binding|transcription coactivator activity				0	all_cancers(76;0.0841)|all_epithelial(76;0.217)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		ATGGCCCGCTCGATTTTGCCA	0.582													12	83					0	0	0	0	G	139757370	G	G	139757370	3	3	97	1	0	0	0	0	1	0	0	0	4936	893	31	3	116	3	EDF1	9	139757370	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	8672672	139757370	1456061	89	18650											
KLF6	1316	broad.mit.edu	37	chr10	3823969	3823969	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttgtcacctggcttcccCgaagtcccgctgcgcacctt	4	10	8	19	3	1	0	1	0	0	0	3	1	3	0	6	1	1	3	6	1	1	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr10:3823969C>G	uc001iha.2	-	2	807	c.540G>C	c.(538-540)TCG>TCC	p.S180S	KLF6_uc010qaj.1_Silent_p.S180S|KLF6_uc010qak.1_Intron|KLF6_uc010qal.1_Silent_p.S180S|KLF6_uc001ihb.2_Silent_p.S180S	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	180			S -> L (found in gastric cancer samples; somatic mutation).		B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		CTGGCTTCCCCGAAGTCCCGC	0.627											OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	79					0	0	0	0	G	3823969	G	G	3823969	2	3	97	1	0	0	0	0	0	0	0	1	8389	639	23	3		3	KLF6	10	3823969	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		3823969	131710778	90	18651											
SUPV3L1	6832	broad.mit.edu	37	chr10	70940261	70940261	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcccctgactgtgaaacctCagggccccagcgccgacggc	7	5	12	17	3	1	2	1	2	0	0	1	3	1	2	6	2	3	0	6	2	1	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr10:70940261C>T	uc001jpe.1	+	1	269	c.214C>T	c.(214-216)CAG>TAG	p.Q72*	SUPV3L1_uc010qjd.1_5'UTR	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	72					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						TGTGAAACCTCAGGGCCCCAG	0.637													24	108					0	0	0	0	T	70940261	T	T	70940261	4	4	97	1	0	0	0	0	0	1	0	0	15468	827	29	2	216	2	SUPV3L1	10	70940261	Nonsense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	67116292	70940261	64594486	91	18652											
MYST4	23522	broad.mit.edu	37	chr10	76788729	76788729	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaatgtagaaaaagatccaGatggtgctaaaagccaagaa	20	6	10	5	0	0	4	0	0	0	4	1	5	1	4	2	1	2	2	2	1	8	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr10:76788729G>C	uc001jwn.1	+	18	4640	c.4147G>C	c.(4147-4149)GAT>CAT	p.D1383H	MYST4_uc001jwo.1_Missense_Mutation_p.D1091H|MYST4_uc001jwp.1_Missense_Mutation_p.D1200H	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1383					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					aaaagaTCCAGATGGTGCTAA	0.249			T	CREBBP	AML								7	46					0	0	0	0	C	76788729	C	C	76788729	3	2	97	1	0	0	0	0	1	0	0	0	10158	942	33	2	4209	2	MYST4	10	76788729	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	5848468	76788729	58746018	92	18653											
WDR11	55717	broad.mit.edu	37	chr10	122619653	122619653	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggaatcaagatgcttccCgcgatttactgcttgctatc	8	14	9	10	2	1	1	1	0	0	1	3	3	2	2	1	1	4	3	1	1	4	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr10:122619653C>T	uc010qtf.1	+	4	623	c.385C>T	c.(385-387)CGC>TGC	p.R129C	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	129	WD 2.					integral to membrane					0						AGATGCTTCCCGCGATTTACT	0.448													26	89					0	0	0	0	T	122619653	T	T	122619653	3	4	97	1	0	0	0	0	1	0	0	0	17341	652	23	1	399	1	WDR11	10	122619653	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	45830924	122619653	12915094	93	18654											
DPYSL4	10570	broad.mit.edu	37	chr10	134008424	134008424	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgggagcgggcggacagcgCggcctgctgcgactactccc	5	4	17	15	6	0	0	0	0	0	0	1	3	1	2	2	4	5	1	2	4	1	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr10:134008424C>T	uc009ybb.2	+	4	543	c.389C>T	c.(388-390)GCG>GTG	p.A130V		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	130					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GCGGACAGCGCGGCCTGCTGC	0.662													13	81					0	0	0	0	T	134008424	T	T	134008424	3	4	97	1	0	0	0	0	1	0	0	0	4771	768	27	1	403	1	DPYSL4	10	134008424	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	11388771	134008424	1526323	94	18655											
MRGPRE	116534	broad.mit.edu	37	chr11	3249416	3249416	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgggggccgctgggggcctCgctccacccgcagcagcagc	4	4	17	16	3	0	0	0	0	0	0	2	0	1	0	4	4	3	5	4	4	0	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr11:3249416C>T	uc001lxq.3	-	2	921	c.611G>A	c.(610-612)CGA>CAA	p.R204Q		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	204	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGGGGGCCTCGCTCCACCCG	0.682													3	8					0	0	0	0	T	3249416	T	T	3249416	3	4	97	1	0	0	0	0	1	0	0	0	9817	884	31	1	328	1	MRGPRE	11	3249416	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		3249416	131757100	95	18656											
IPO7	10527	broad.mit.edu	37	chr11	9456494	9456494	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatacagatatgatgcccctCcttcataattatgtaacagt	14	13	5	9	0	1	2	1	1	0	1	2	2	2	2	3	0	3	1	3	0	6	6			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr11:9456494C>T	uc001mho.2	+	19	2230	c.2088C>T	c.(2086-2088)CTC>CTT	p.L696L		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	696					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TGATGCCCCTCCTTCATAATT	0.313													9	81					0	0	0	0	T	9456494	T	T	9456494	2	4	97	1	0	0	0	0	0	0	0	1	7836	842	30	2		2	IPO7	11	9456494	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	6207078	9456494	125550022	96	18657											
TP53I11	9537	broad.mit.edu	37	chr11	44956498	44956498	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgctgatgacgacaaaaagGaggcggctgaccaggagcag	14	4	15	8	2	0	3	0	3	0	0	0	6	0	5	1	4	2	3	1	4	2	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr11:44956498G>T	uc001myi.2	-	10	1112	c.507C>A	c.(505-507)CTC>CTA	p.L169L	TP53I11_uc001myf.1_Intron|TP53I11_uc001myj.2_Silent_p.L169L|TP53I11_uc001myk.2_Silent_p.L169L|TP53I11_uc001myl.2_Silent_p.L169L|TP53I11_uc001mym.2_Silent_p.L116L	NM_006034	NP_006025	O14683	P5I11_HUMAN	p53-induced protein	169	Helical; (Potential).				negative regulation of cell proliferation|response to stress	integral to membrane				ovary(1)	1						CGACAAAAAGGAGGCGGCTGA	0.617													19	137					7.92952e-12	8.9259e-12	1	0	T	44956498	T	T	44956498	2	4	97	1	0	0	0	0	0	0	0	1	16452	1161	41	2		2	TP53I11	11	44956498	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	35500004	44956498	90050018	97	18658											
ZBTB3	79842	broad.mit.edu	37	chr11	62520951	62520951	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattgtgaatacacaccagAtccctcttgtccaattcccg	10	12	5	14	1	2	2	1	1	1	1	5	2	5	2	4	0	1	0	4	0	3	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr11:62520951A>T	uc001nuz.2	-	2	458	c.336T>A	c.(334-336)GAT>GAA	p.D112E		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	112	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						TACACACCAGATCCCTCTTGT	0.547													16	71					0	0	0	0	T	62520951	T	T	62520951	3	4	97	1	0	0	0	0	1	0	0	0	17601	330	12	5	1392	5	ZBTB3	11	62520951	Missense_Mutation	SNP	A	TCGA-CQ-5331-01A-02D-1870-08	17564453	62520951	72485565	98	18659											
CDCA5	113130	broad.mit.edu	37	chr11	64846603	64846603	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaaccaggagatcaaactgCtcagcagcttcaaactcggc	13	7	8	13	1	4	1	4	0	0	1	5	2	4	1	1	2	6	3	1	2	3	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr11:64846603C>G	uc001ocp.2	-	6	900	c.735G>C	c.(733-735)GAG>GAC	p.E245D		NM_080668	NP_542399	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	245					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding				0						GATCAAACTGCTCAGCAGCTT	0.552													4	34					0	0	0	0	G	64846603	G	G	64846603	3	3	97	1	0	0	0	0	1	0	0	0	3104	796	28	4	27	4	CDCA5	11	64846603	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	2325652	64846603	70159913	99	18660											
RSF1	51773	broad.mit.edu	37	chr11	77412091	77412091	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgatgccctctttctgcCtttcagaggttatctctgta	6	18	7	10	0	4	2	1	1	3	1	5	2	4	2	2	1	2	2	2	1	2	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr11:77412091C>A	uc001oyn.2	-	6	2303	c.2183G>T	c.(2182-2184)AGG>ATG	p.R728M	RSF1_uc001oym.2_Missense_Mutation_p.R476M	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	728					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			CTCTTTCTGCCTTTCAGAGGT	0.398													27	157					7.07758e-08	7.68525e-08	1	0	A	77412091	A	A	77412091	3	1	97	1	0	0	0	0	1	0	0	0	13764	681	24	4	2186	4	RSF1	11	77412091	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	12565488	77412091	57594425	100	18661											
USP28	57646	broad.mit.edu	37	chr11	113670017	113670017	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actccatgacagctgcaaatCggctacataggtcataggga	13	8	10	10	1	1	1	1	1	0	0	3	2	2	2	1	3	3	3	1	3	4	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr11:113670017C>A	uc001poh.2	-	25	3212	c.3179G>T	c.(3178-3180)CGA>CTA	p.R1060L	USP28_uc001pog.2_Missense_Mutation_p.R736L|USP28_uc010rwy.1_Missense_Mutation_p.R903L|USP28_uc001poi.2_Missense_Mutation_p.R383L	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	1060					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		AGCTGCAAATCGGCTACATAG	0.483													27	137					7.38237e-10	8.22388e-10	1	0	A	113670017	A	A	113670017	3	1	97	1	0	0	0	0	1	0	0	0	17126	884	31	3	58	3	USP28	11	113670017	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	36257926	113670017	21336499	101	18662											
RIMKLB	57494	broad.mit.edu	37	chr12	8926332	8926332	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctcccagggggcctgttCaacatgaaccagctgctagc	10	7	11	13	0	1	1	1	1	0	0	2	1	2	1	3	2	6	4	3	2	4	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr12:8926332C>G	uc001quu.2	+	6	1364	c.1113C>G	c.(1111-1113)TTC>TTG	p.F371L	RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_Missense_Mutation_p.F371L|RIMKLB_uc010sgl.1_Missense_Mutation_p.F371L|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	371					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						GGGGCCTGTTCAACATGAACC	0.483													18	128					0	0	0	0	G	8926332	G	G	8926332	3	3	97	1	0	0	0	0	1	0	0	0	13431	825	29	2	1131	2	RIMKLB	12	8926332	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		8926332	124925563	102	18663											
EPS8	2059	broad.mit.edu	37	chr12	15784565	15784565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatggagcagggggagtatCagctggtcttgggccatact	8	10	16	7	0	2	1	1	1	1	0	2	3	2	3	1	5	3	3	1	5	2	3	rs145919374		TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr12:15784565C>T	uc009zif.2	-	18	1949	c.1855G>A	c.(1855-1857)GAT>AAT	p.D619N	EPS8_uc001rdb.2_Missense_Mutation_p.D619N|EPS8_uc009zig.2_Missense_Mutation_p.D359N|EPS8_uc010shv.1_Missense_Mutation_p.D359N	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	619	Pro-rich.				cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		GGGGGAGTATCAGCTGGTCTT	0.433													7	67					0	0	0	0	T	15784565	T	T	15784565	3	4	97	1	0	0	0	0	1	0	0	0	5218	826	29	2	629	2	EPS8	12	15784565	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	6858233	15784565	118067330	103	18664											
STK38L	23012	broad.mit.edu	37	chr12	27461352	27461352	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagacttggcttggatgaCtttgagtctctgaaagttat	10	14	10	7	0	1	4	0	3	1	1	2	5	1	5	1	2	0	2	1	2	2	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr12:27461352C>G	uc001rhr.2	+	4	466	c.267C>G	c.(265-267)GAC>GAG	p.D89E	STK38L_uc001rhs.2_RNA|STK38L_uc010sjm.1_Intron	NM_015000	NP_055815	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	89					intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|kidney(1)	5	Colorectal(261;0.0847)					GCTTGGATGACTTTGAGTCTC	0.353													33	133					0	0	0	0	G	27461352	G	G	27461352	3	3	97	1	0	0	0	0	1	0	0	0	15370	564	20	4	277	4	STK38L	12	27461352	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	11676787	27461352	106390543	104	18665											
BICD1	636	broad.mit.edu	37	chr12	32369283	32369283	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcgaaggaggcttactatCtggggaagatcttggagatg	11	10	14	6	1	2	2	0	0	2	2	3	6	2	4	0	5	1	1	0	5	4	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr12:32369283C>G	uc001rku.2	+	2	397	c.316C>G	c.(316-318)CTG>GTG	p.L106V	BICD1_uc001rkv.2_Missense_Mutation_p.L106V|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	106	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			GGCTTACTATCTGGGGAAGAT	0.542													14	69					0	0	0	0	G	32369283	G	G	32369283	3	3	97	1	0	0	0	0	1	0	0	0	1431	912	32	2	322	2	BICD1	12	32369283	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	4907931	32369283	101482612	105	18666											
ASB8	140461	broad.mit.edu	37	chr12	48545077	48545077	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgtgccatgagtgcagttCacatctgctccctgtgggca	7	11	12	11	0	2	1	1	1	1	0	3	1	3	1	2	1	3	4	2	1	0	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr12:48545077C>G	uc001rrh.2	-	3	310	c.141G>C	c.(139-141)GTG>GTC	p.V47V	ASB8_uc010slr.1_Silent_p.V43V	NM_024095	NP_077000	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box-containing 8	47					intracellular signal transduction	cytoplasm|nucleus				kidney(1)	1						GAGTGCAGTTCACATCTGCTC	0.522													12	46					0	0	0	0	G	48545077	G	G	48545077	2	3	97	1	0	0	0	0	0	0	0	1	1031	813	29	2		2	ASB8	12	48545077	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	16175794	48545077	85306818	106	18667											
KRT74	121391	broad.mit.edu	37	chr12	52962128	52962128	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcatccttcagggcattgtCtccccgctgctcagcgtcag	5	10	11	15	2	4	0	3	0	1	0	6	0	5	0	3	2	2	4	3	2	0	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr12:52962128C>G	uc001sap.1	-	7	1228	c.1180G>C	c.(1180-1182)GAC>CAC	p.D394H		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	394	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		AGGGCATTGTCTCCCCGCTGC	0.597													10	62					0	0	0	0	G	52962128	G	G	52962128	3	3	97	1	0	0	0	0	1	0	0	0	8526	913	32	2	421	2	KRT74	12	52962128	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	4417051	52962128	80889767	107	18668											
R3HDM2	22864	broad.mit.edu	37	chr12	57660580	57660580	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaggcatctggtactgctCagagccagggggttgcagaa	9	8	15	9	0	2	3	1	1	1	2	2	3	2	3	1	4	4	5	1	4	2	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr12:57660580C>G	uc009zpm.1	-	17	2058	c.2023G>C	c.(2023-2025)GAG>CAG	p.E675Q	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_Missense_Mutation_p.E370Q|R3HDM2_uc001snr.2_Missense_Mutation_p.E402Q|R3HDM2_uc001sns.2_Missense_Mutation_p.E675Q|R3HDM2_uc001snt.2_Missense_Mutation_p.E689Q|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	675	Gln-rich.					nucleus	nucleic acid binding			ovary(2)	2						TGGTACTGCTCAGAGCCAGGG	0.552													8	42					0	0	0	0	G	57660580	G	G	57660580	3	3	97	1	0	0	0	0	1	0	0	0	12953	835	29	2	931	2	R3HDM2	12	57660580	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	4698452	57660580	76191315	108	18669											
GNPTAB	79158	broad.mit.edu	37	chr12	102153834	102153834	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggatcatagtaggattcctGagttggtggaatattattta	11	15	12	3	0	1	1	1	1	0	0	2	4	2	4	1	4	0	2	1	4	6	8			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr12:102153834G>A	uc001tit.2	-	16	3402	c.3223C>T	c.(3223-3225)CAG>TAG	p.Q1075*		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	1075					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity	p.Q1075*(1)		ovary(1)|skin(1)	2						TAGGATTCCTGAGTTGGTGGA	0.368													13	89					0	0	0	0	A	102153834	A	A	102153834	4	1	97	1	0	0	0	0	0	1	0	0	6582	1299	45	2	571	2	GNPTAB	12	102153834	Nonsense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	44493254	102153834	31698061	109	18670											
PDS5B	23047	broad.mit.edu	37	chr13	33344579	33344579	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaacttctaaaaaaggaagCaaaaaaaaatctggacctcc	22	6	5	8	0	2	0	0	0	2	0	3	2	3	2	2	2	2	1	2	2	10	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr13:33344579C>G	uc010abf.2	+	32	4103	c.3945C>G	c.(3943-3945)AGC>AGG	p.S1315R	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	1315					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		AAAAAGGAAGCAAAAAAAAAT	0.438													4	34					0	0	0	0	G	33344579	G	G	33344579	3	3	97	1	0	0	0	0	1	0	0	0	11746	709	25	4	4067	4	PDS5B	13	33344579	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		33344579	81825299	110	18671											
FAM124A	220108	broad.mit.edu	37	chr13	51854623	51854623	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagtttcctaaacctggcaGagtacatcatgcctccgaga	12	9	9	11	1	1	2	1	0	0	2	3	4	3	2	4	1	3	3	4	1	4	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr13:51854623G>C	uc001vfg.1	+	4	1003	c.872G>C	c.(871-873)AGA>ACA	p.R291T	FAM124A_uc001vff.1_Missense_Mutation_p.R327T	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	291										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		AAACCTGGCAGAGTACATCAT	0.517													8	46					0	0	0	0	C	51854623	C	C	51854623	3	2	97	1	0	0	0	0	1	0	0	0	5453	942	33	2	998	2	FAM124A	13	51854623	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	18510044	51854623	63315255	111	18672											
C13orf34	79866	broad.mit.edu	37	chr13	73327930	73327930	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcacaaacatgtgaagttGagagtaaatctcaagcattt	16	11	8	6	0	1	2	1	2	1	1	2	3	1	2	0	0	3	4	0	0	5	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr13:73327930G>A	uc001viv.1	+	11	1704	c.1585G>A	c.(1585-1587)GAG>AAG	p.E529K	C13orf34_uc010aen.1_Missense_Mutation_p.E604K|C13orf34_uc010thr.1_Missense_Mutation_p.E459K|C13orf34_uc001viw.1_Missense_Mutation_p.E478K	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	529					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		ATGTGAAGTTGAGAGTAAATC	0.313													6	70					0	0	0	0	A	73327930	A	A	73327930	3	1	97	1	0	0	0	0	1	0	0	0	1734	1291	45	2	1623	2	C13orf34	13	73327930	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	21473307	73327930	41841948	112	18673											
ING1	3621	broad.mit.edu	37	chr13	111372242	111372242	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaccatggacaaagcccTggagaaatccaaaaaagaga	20	3	10	8	0	0	3	0	0	0	3	1	7	1	4	3	2	1	0	3	2	6	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr13:111372242T>G	uc001vri.2	+	2	1664	c.1232T>G	c.(1231-1233)CTG>CGG	p.L411R	ING1_uc001vrf.2_Missense_Mutation_p.L224R|ING1_uc001vrg.2_Missense_Mutation_p.L199R|ING1_uc001vrh.2_Missense_Mutation_p.L268R	NM_005537	NP_005528	Q9UK53	ING1_HUMAN	inhibitor of growth family, member 1 isoform D	411					cell cycle|negative regulation of cell growth|negative regulation of cell proliferation	nucleus	zinc ion binding			ovary(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.188)			GACAAAGCCCTGGAGAAATCC	0.507													8	26					0	0	0	0	G	111372242	G	G	111372242	3	3	97	1	0	0	0	0	1	0	0	0	7774	1580	55	5	1386	5	ING1	13	111372242	Missense_Mutation	SNP	T	TCGA-CQ-5331-01A-02D-1870-08	38044312	111372242	3797636	113	18674											
ATP11A	23250	broad.mit.edu	37	chr13	113478732	113478732	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatctcagaagcgatctgccGtggaaaagtaaggctggatg	13	8	13	7	2	2	1	1	0	2	1	3	4	2	3	1	3	2	2	1	3	5	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr13:113478732G>A	uc001vsi.3	+	10	953	c.865G>A	c.(865-867)GTG>ATG	p.V289M	ATP11A_uc001vsj.3_Missense_Mutation_p.V289M|ATP11A_uc001vsm.1_Missense_Mutation_p.V165M	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	289	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GCGATCTGCCGTGGAAAAGTA	0.443													13	85					0	0	0	0	A	113478732	A	A	113478732	3	1	97	1	0	0	0	0	1	0	0	0	1121	1145	40	1	903	1	ATP11A	13	113478732	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	2106490	113478732	1691146	114	18675											
MMP14	4323	broad.mit.edu	37	chr14	23313957	23313957	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctctcttctggatgccCaatggaaagacctacttctt	8	13	8	12	0	3	1	0	0	3	1	4	3	3	3	2	2	3	2	2	2	3	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr14:23313957C>T	uc001whc.2	+	8	1503	c.1269C>T	c.(1267-1269)CCC>CCT	p.P423P		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	423	Hemopexin-like 3.|Extracellular (Potential).					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TCTGGATGCCCAATGGAAAGA	0.547													18	137					0	0	0	0	T	23313957	T	T	23313957	2	4	97	1	0	0	0	0	0	0	0	1	9706	581	21	4		4	MMP14	14	23313957	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		23313957	84035583	115	18676											
DAAM1	23002	broad.mit.edu	37	chr14	59820601	59820601	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgctcttacagaattaatCactatcagcaaaggttgcaa	14	13	6	8	0	3	1	2	0	1	1	3	1	3	1	0	1	4	4	0	1	6	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr14:59820601C>T	uc001xdz.1	+	20	2430	c.2305C>T	c.(2305-2307)CAC>TAC	p.H769Y	DAAM1_uc001xea.1_Missense_Mutation_p.H759Y|DAAM1_uc001xec.1_5'Flank	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	769	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CAGAATTAATCACTATCAGCA	0.378													3	25					0	0	0	0	T	59820601	T	T	59820601	3	4	97	1	0	0	0	0	1	0	0	0	4232	826	29	2	2379	2	DAAM1	14	59820601	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	36506644	59820601	47528939	116	18677											
RPS6KL1	83694	broad.mit.edu	37	chr14	75376489	75376489	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggaacccaagtgagcccccGagggggcccagcgtctgagt	9	4	15	13	2	1	2	0	2	1	0	1	4	1	3	4	3	3	0	4	3	2	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr14:75376489G>A	uc010tux.1	-	7	1555	c.1027C>T	c.(1027-1029)CGG>TGG	p.R343W	RPS6KL1_uc001xqx.1_Missense_Mutation_p.R95W|RPS6KL1_uc001xqw.2_Missense_Mutation_p.R312W|RPS6KL1_uc010asd.1_RNA	NM_031464	NP_113652	Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	343	Protein kinase.					ribosome	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00658)		GTGAGCCCCCGAGGGGGCCCA	0.697													7	36					0	0	0	0	A	75376489	A	A	75376489	3	1	97	1	0	0	0	0	1	0	0	0	13724	1057	37	1	715	1	RPS6KL1	14	75376489	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	15555888	75376489	31973051	117	18678											
RPS6KA5	9252	broad.mit.edu	37	chr14	91389537	91389537	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaaaaggaatatgctctttCagtcttgaacaaacaaacaa	19	9	5	8	0	3	1	1	1	2	0	3	2	3	2	0	1	4	1	0	1	8	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr14:91389537C>G	uc001xys.2	-	6	837	c.622G>C	c.(622-624)GAA>CAA	p.E208Q	RPS6KA5_uc010twi.1_Missense_Mutation_p.E129Q|RPS6KA5_uc001xyt.2_Missense_Mutation_p.E208Q|RPS6KA5_uc010att.1_RNA	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	208	Protein kinase 1.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		TATGCTCTTTCAGTCTTGAAC	0.353													6	37					0	0	0	0	G	91389537	G	G	91389537	3	3	97	1	0	0	0	0	1	0	0	0	13719	835	29	2	1840	2	RPS6KA5	14	91389537	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	16013048	91389537	15960003	118	18679											
BEGAIN	57596	broad.mit.edu	37	chr14	101012923	101012923	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggcgcgtggagtcgaactCggtctcgagcttctcgagct	5	10	15	11	6	2	0	0	0	2	0	6	4	2	1	0	3	3	2	0	3	1	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr14:101012923C>T	uc010txa.1	-	2	237	c.91G>A	c.(91-93)GAG>AAG	p.E31K	BEGAIN_uc001yhp.2_5'UTR|BEGAIN_uc001yhq.2_Missense_Mutation_p.E31K	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	31						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)				GAGTCGAACTCGGTCTCGAGC	0.562													9	51					0	0	0	0	T	101012923	T	T	101012923	3	4	97	1	0	0	0	0	1	0	0	0	1399	893	31	1	1710	1	BEGAIN	14	101012923	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	9623386	101012923	6336617	119	18680											
DISP2	85455	broad.mit.edu	37	chr15	40661167	40661167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttggttcactagccgtctaGagctgtatagcctgcagcac	8	11	11	11	1	2	1	1	0	1	1	2	1	2	1	2	1	5	6	2	1	4	6			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr15:40661167G>A	uc001zlk.1	+	8	2943	c.2854G>A	c.(2854-2856)GAG>AAG	p.E952K		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	952					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TAGCCGTCTAGAGCTGTATAG	0.632													19	103					0	0	0	0	A	40661167	A	A	40661167	3	1	97	1	0	0	0	0	1	0	0	0	4562	943	33	2	2884	2	DISP2	15	40661167	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08		40661167	61870225	120	18681											
SPINT1	6692	broad.mit.edu	37	chr15	41145359	41145359	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctgggcaggcatagacttGaaggtacaaccccaggaacc	12	5	12	12	0	0	2	0	1	0	1	0	3	0	3	4	4	3	3	4	4	5	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr15:41145359G>C	uc001zna.2	+	3	717	c.513G>C	c.(511-513)TTG>TTC	p.L171F	SPINT1_uc001znb.2_Missense_Mutation_p.L171F|SPINT1_uc001znc.2_Missense_Mutation_p.L171F|SPINT1_uc010ucs.1_Missense_Mutation_p.L171F	NM_181642	NP_857593	O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	171						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GCATAGACTTGAAGGTACAAC	0.557													25	150					0	0	0	0	C	41145359	C	C	41145359	3	2	97	1	0	0	0	0	1	0	0	0	15134	1281	45	2	519	2	SPINT1	15	41145359	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	484192	41145359	61386033	121	18682											
UBR1	197131	broad.mit.edu	37	chr15	43351984	43351984	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatctctgagtgtaatacttCtacatgaagtggatgttgag	12	14	10	5	0	2	3	0	3	2	0	3	4	2	4	0	1	2	2	0	1	5	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr15:43351984C>G	uc001zqq.2	-	8	967	c.901G>C	c.(901-903)GAA>CAA	p.E301Q	UBR1_uc010udk.1_Missense_Mutation_p.E301Q	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	301					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		TGTAATACTTCTACATGAAGT	0.353													8	49					0	0	0	0	G	43351984	G	G	43351984	3	3	97	1	0	0	0	0	1	0	0	0	16969	922	32	2	4508	2	UBR1	15	43351984	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	2206625	43351984	59179408	122	18683											
LCMT2	9836	broad.mit.edu	37	chr15	43622444	43622444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagagacaagatctgcgcgcGaagcgcggcctggggcgcgc	8	3	18	12	7	1	2	0	0	1	2	1	5	1	2	1	3	2	0	1	3	2	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr15:43622444G>A	uc001zrg.2	-	1	448	c.244C>T	c.(244-246)CGC>TGC	p.R82C	LCMT2_uc010udn.1_Intron|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	82					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	ATCTGCGCGCGAAGCGCGGCC	0.652													5	48					0	0	0	0	A	43622444	A	A	43622444	3	1	97	1	0	0	0	0	1	0	0	0	8719	1058	37	1	1820	1	LCMT2	15	43622444	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	270460	43622444	58908948	123	18684											
MAP1A	4130	broad.mit.edu	37	chr15	43814803	43814803	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagaagcctgccaagcctGagagggtgaagacagagtca	14	4	14	9	0	1	5	1	2	0	4	1	7	1	5	3	1	3	0	3	1	3	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr15:43814803G>A	uc001zrt.2	+	4	1599	c.1132G>A	c.(1132-1134)GAG>AAG	p.E378K		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	378	Lys-rich (basic).					cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TGCCAAGCCTGAGAGGGTGAA	0.493													4	29					0	0	0	0	A	43814803	A	A	43814803	3	1	97	1	0	0	0	0	1	0	0	0	9280	1291	45	2	1134	2	MAP1A	15	43814803	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	192359	43814803	58716589	124	18685											
SLC12A1	6557	broad.mit.edu	37	chr15	48500096	48500096	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcagaaaagactcagaatCagctttaggcctgggaatca	14	8	10	9	0	4	3	4	0	0	3	4	4	4	4	1	2	1	2	1	2	5	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr15:48500096C>T	uc001zwn.3	+	2	396	c.180C>T	c.(178-180)ATC>ATT	p.I60I	SLC12A1_uc010uew.1_Intron|SLC12A1_uc010bem.2_Silent_p.I60I|SLC12A1_uc010uex.1_Silent_p.I60I	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	60	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GACTCAGAATCAGCTTTAGGC	0.438													9	62					0	0	0	0	T	48500096	T	T	48500096	2	4	97	1	0	0	0	0	0	0	0	1	14447	816	29	2		2	SLC12A1	15	48500096	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	4685293	48500096	54031296	125	18686											
SLC27A2	11001	broad.mit.edu	37	chr15	50519205	50519205	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggacttctggtttgcaaaatCacacaacttacaccatttaa	14	12	5	10	0	2	0	1	0	1	0	2	1	2	1	1	2	3	2	1	2	5	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr15:50519205C>T	uc001zxw.2	+	7	1519	c.1287C>T	c.(1285-1287)ATC>ATT	p.I429I	SLC27A2_uc010bes.2_Silent_p.I376I|SLC27A2_uc001zxx.2_Silent_p.I194I	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	429	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		TTTGCAAAATCACACAACTTA	0.358													5	43					0	0	0	0	T	50519205	T	T	50519205	2	4	97	1	0	0	0	0	0	0	0	1	14590	816	29	2		2	SLC27A2	15	50519205	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	2019109	50519205	52012187	126	18687											
CPEB1	64506	broad.mit.edu	37	chr15	83215266	83215266	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttctaggtaggggtcaatCtgaacctgcacaaaggcaaa	13	9	10	9	0	4	1	1	1	3	0	4	1	4	1	1	4	2	3	1	4	6	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr15:83215266C>G	uc002bit.2	-	11	1832	c.1695G>C	c.(1693-1695)CAG>CAC	p.Q565H	CPEB1_uc002biq.2_Missense_Mutation_p.Q425H|CPEB1_uc002bir.2_Missense_Mutation_p.Q430H|CPEB1_uc002bis.2_Missense_Mutation_p.Q425H|CPEB1_uc010uod.1_Missense_Mutation_p.Q274H|CPEB1_uc010uoe.1_Missense_Mutation_p.Q503H|CPEB1_uc002biu.2_Missense_Mutation_p.Q527H|CPEB1_uc010uof.1_Missense_Mutation_p.Q425H|CPEB1_uc002biv.2_Missense_Mutation_p.Q500H|CPEB1_uc002bip.2_Missense_Mutation_p.Q274H	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	505	RRM 2.|Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			AGGGGTCAATCTGAACCTGCA	0.483													8	74					0	0	0	0	G	83215266	G	G	83215266	3	3	97	1	0	0	0	0	1	0	0	0	3815	912	32	2	193	2	CPEB1	15	83215266	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	32696061	83215266	19316126	127	18688											
IQGAP1	8826	broad.mit.edu	37	chr15	90934036	90934036	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatgaaagacttactgcagAggagatggatgaaaggagac	17	7	13	4	0	0	6	0	2	0	4	0	9	0	7	0	3	2	1	0	3	4	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr15:90934036A>T	uc002bpl.1	+	2	187	c.86A>T	c.(85-87)GAG>GTG	p.E29V		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	29					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CTTACTGCAGAGGAGATGGAT	0.423													10	103					0	0	0	0	T	90934036	T	T	90934036	3	4	97	1	0	0	0	0	1	0	0	0	7853	304	11	5	92	5	IQGAP1	15	90934036	Missense_Mutation	SNP	A	TCGA-CQ-5331-01A-02D-1870-08	7718770	90934036	11597356	128	18689											
STUB1	10273	broad.mit.edu	37	chr16	731286	731286	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtctgtgaaggcgcacttCttcctggggcagtgccagct	6	10	13	12	1	2	1	0	1	2	0	3	1	3	1	2	3	2	3	2	3	1	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr16:731286C>T	uc002cit.2	+	2	705	c.294C>T	c.(292-294)TTC>TTT	p.F98F	STUB1_uc002ciu.2_Silent_p.F26F|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	98	TPR 3.				cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				AGGCGCACTTCTTCCTGGGGC	0.652													3	27					0	0	0	0	T	731286	T	T	731286	2	4	97	1	0	0	0	0	0	0	0	1	15401	912	32	2		2	STUB1	16	731286	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		731286	89623467	129	18690											
ZC3H7A	29066	broad.mit.edu	37	chr16	11862205	11862205	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagatctggcaagcttgtctCaattcatgggttccttcgag	8	13	10	10	1	3	1	2	0	2	1	6	2	4	1	1	2	1	3	1	2	2	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr16:11862205C>G	uc002dbk.2	-	11	1524	c.1326G>C	c.(1324-1326)TTG>TTC	p.L442F	ZC3H7A_uc002dbj.2_5'Flank|ZC3H7A_uc002dbl.2_Missense_Mutation_p.L442F|ZC3H7A_uc002dbm.1_Missense_Mutation_p.L352F	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	442						nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						AAGCTTGTCTCAATTCATGGG	0.413													38	181					0	0	0	0	G	11862205	G	G	11862205	3	3	97	1	0	0	0	0	1	0	0	0	17639	825	29	2	1637	2	ZC3H7A	16	11862205	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	11130919	11862205	78492548	130	18691											
DCUN1D3	123879	broad.mit.edu	37	chr16	20871316	20871316	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactccacaaaggtgtcaaaGagacttggccaggcctcatc	12	7	9	13	0	2	1	2	0	0	1	4	2	3	1	3	3	0	0	3	3	2	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr16:20871316G>C	uc002dhz.2	-	3	948	c.807C>G	c.(805-807)CTC>CTG	p.L269L	ERI2_uc002dht.3_Intron	NM_173475	NP_775746	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain	269	DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				ovary(2)	2				GBM - Glioblastoma multiforme(48;0.249)		AGGTGTCAAAGAGACTTGGCC	0.552													7	39					0	0	0	0	C	20871316	C	C	20871316	2	2	97	1	0	0	0	0	0	0	0	1	4332	929	33	2		2	DCUN1D3	16	20871316	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	9009111	20871316	69483437	131	18692											
USP31	57478	broad.mit.edu	37	chr16	23116891	23116891	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatacactacagtgacataGagaggcctgtacagatcaaa	16	8	9	8	0	1	4	1	2	0	2	1	5	1	4	1	1	3	1	1	1	5	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr16:23116891G>A	uc002dll.2	-	5	960	c.960C>T	c.(958-960)CTC>CTT	p.L320L		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	320					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		CAGTGACATAGAGAGGCCTGT	0.418													11	52					0	0	0	0	A	23116891	A	A	23116891	2	1	97	1	0	0	0	0	0	0	0	1	17130	929	33	2		2	USP31	16	23116891	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	2245575	23116891	67237862	132	18693											
TNRC6A	27327	broad.mit.edu	37	chr16	24800705	24800705	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cagcccctggcagtgatccgGagttggcttcagaatgtatg	8	10	13	10	1	1	2	1	1	0	1	2	3	2	3	3	3	1	4	3	3	2	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr16:24800705G>C	uc002dmm.2	+	6	856	c.742G>C	c.(742-744)GAG>CAG	p.E248Q	TNRC6A_uc010bxs.2_5'UTR|TNRC6A_uc010vcc.1_5'UTR|TNRC6A_uc002dmn.2_5'UTR|TNRC6A_uc002dmo.2_5'UTR	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	248	Ser-rich.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		CAGTGATCCGGAGTTGGCTTC	0.458													10	122					0	0	0	0	C	24800705	C	C	24800705	3	2	97	1	0	0	0	0	1	0	0	0	16406	1175	41	2	764	2	TNRC6A	16	24800705	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	1683814	24800705	65554048	133	18694											
CCDC135	84229	broad.mit.edu	37	chr16	57741450	57741450	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgtgctatcggggaagcgcGaggtgcctgagaacttcttc	7	11	14	9	3	1	1	0	1	1	1	3	4	1	2	1	3	4	1	1	3	3	4	rs116219187	by1000genomes	TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr16:57741450G>A	uc002emi.2	+	7	1026	c.937G>A	c.(937-939)GAG>AAG	p.E313K	CCDC135_uc002emj.2_Missense_Mutation_p.E313K|CCDC135_uc002emk.2_Missense_Mutation_p.E248K	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	313						cytoplasm				central_nervous_system(1)	1						GGGGAAGCGCGAGGTGCCTGA	0.587													10	52					0	0	0	0	A	57741450	A	A	57741450	3	1	97	1	0	0	0	0	1	0	0	0	2781	1059	37	1	959	1	CCDC135	16	57741450	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	32940745	57741450	32613303	134	18695											
TMED6	146456	broad.mit.edu	37	chr16	69385485	69385485	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtctggtgggcaaattGccaaaagcattccgtgcctc	9	10	10	12	1	1	0	0	0	1	0	4	0	3	0	4	2	3	2	4	2	3	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr16:69385485G>T	uc002exc.1	-	1	205	c.172C>A	c.(172-174)CAA>AAA	p.Q58K		NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain	58	Lumenal (Potential).|GOLD.				transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1						TGGGCAAATTGCCAAAAGCAT	0.483													17	131					5.35267e-07	5.72549e-07	1	0	T	69385485	T	T	69385485	3	4	97	1	0	0	0	0	1	0	0	0	16074	1328	46	4	566	4	TMED6	16	69385485	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	11644035	69385485	20969268	135	18696											
WWP2	11060	broad.mit.edu	37	chr16	69969816	69969816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccctttctacaagcggatgCtcaataagagaccaaccctg	12	9	7	13	1	2	1	1	0	1	1	3	3	3	2	3	1	4	1	3	1	5	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr16:69969816C>T	uc002exu.1	+	19	1992	c.1903C>T	c.(1903-1905)CTC>TTC	p.L635F	WWP2_uc002exv.1_Missense_Mutation_p.L635F|WWP2_uc010vlm.1_Missense_Mutation_p.L519F|WWP2_uc010vln.1_Missense_Mutation_p.L253F|WWP2_uc002exw.1_Missense_Mutation_p.L196F	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	635	HECT.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						CAAGCGGATGCTCAATAAGAG	0.547													32	157					0	0	0	0	T	69969816	T	T	69969816	3	4	97	1	0	0	0	0	1	0	0	0	17484	797	28	4	1973	4	WWP2	16	69969816	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	584331	69969816	20384937	136	18697											
ZFHX3	463	broad.mit.edu	37	chr16	72830136	72830136	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcatctgtgatcctggtgcGaggcctcttgttctgctgct	4	15	11	11	1	4	1	1	1	3	0	5	2	5	1	2	2	3	3	2	2	0	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr16:72830136G>A	uc002fck.2	-	9	7118	c.6445C>T	c.(6445-6447)CGC>TGC	p.R2149C	ZFHX3_uc002fcl.2_Missense_Mutation_p.R1235C	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2149	Homeobox 1.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				ATCCTGGTGCGAGGCCTCTTG	0.547													12	64					0	0	0	0	A	72830136	A	A	72830136	3	1	97	1	0	0	0	0	1	0	0	0	17701	1058	37	1	4674	1	ZFHX3	16	72830136	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	2860320	72830136	17524617	137	18698											
TSR1	55720	broad.mit.edu	37	chr17	2234280	2234280	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcttcaacctctttaaaGatgcttttcctagtgttagt	8	20	5	8	0	3	1	1	0	2	1	4	1	4	1	2	0	2	2	2	0	5	9			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:2234280G>T	uc002fuj.2	-	9	2577	c.1620C>A	c.(1618-1620)ATC>ATA	p.I540I	SNORD91B_uc002fuk.1_5'Flank|SNORD91A_uc002ful.1_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	540					ribosome assembly	nucleolus	protein binding			ovary(1)	1						CCTCTTTAAAGATGCTTTTCC	0.393													7	66					2.0095e-06	2.13882e-06	1	0	T	2234280	T	T	2234280	2	4	97	1	0	0	0	0	0	0	0	1	16731	932	33	2		2	TSR1	17	2234280	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08		2234280	78960930	138	18699											
CAMKK1	84254	broad.mit.edu	37	chr17	3783646	3783646	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccccgcactcacagtactCgaggcccaggatgacgtccc	8	6	10	17	3	1	1	1	1	0	0	3	3	2	2	4	2	2	2	4	2	1	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:3783646C>T	uc002fwt.2	-	9	884	c.790G>A	c.(790-792)GAG>AAG	p.E264K	CAMKK1_uc002fwu.2_Missense_Mutation_p.E264K|CAMKK1_uc002fwv.2_Missense_Mutation_p.E302K	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	264	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		TCACAGTACTCGAGGCCCAGG	0.652													7	38					0	0	0	0	T	3783646	T	T	3783646	3	4	97	1	0	0	0	0	1	0	0	0	2618	893	31	1	763	1	CAMKK1	17	3783646	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	1549366	3783646	77411564	139	18700											
TP53	7157	broad.mit.edu	37	chr17	7576927	7576927	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctggtgttgttgggcagtgCtaggaaagaggcaaggaaag	11	8	18	4	0	0	1	0	0	0	1	0	3	0	3	0	5	1	6	0	5	4	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:7576927C>G	uc002gim.2	-	9	1114	c.920_splice	c.e9-1	p.A307_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.A307_splice|TP53_uc010cne.1_Splice_Site|TP53_uc010cnf.1_Splice_Site_p.A175_splice|TP53_uc010cng.1_Splice_Site_p.A175_splice|TP53_uc002gii.1_Splice_Site_p.A175_splice|TP53_uc010cnh.1_Splice_Site_p.A307_splice|TP53_uc010cni.1_Splice_Site_p.A307_splice|TP53_uc002gij.2_Splice_Site_p.A307_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(16)|p.0?(7)|p.A307fs*34(1)|p.L308fs*31(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGGCAGTGCTAGGAAAGAG	0.493		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	73					0	0	0	0	G	7576927	G	G	7576927	5	3	97	1	0	0	0	0	0	0	1	0	16448	811	28	4	363	4	TP53	17	7576927	Splice_Site	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	3793281	7576927	73618283	140	18701											
TP53	7157	broad.mit.edu	37	chr17	7577099	7577099	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcctctgtgcgccggtctCtcccaggacaggcacaaaca	8	8	9	16	2	2	0	0	0	2	0	5	1	4	1	3	3	2	1	3	3	1	1	rs121912660		TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:7577099C>G	uc002gim.2	-	8	1033	c.839G>C	c.(838-840)AGA>ACA	p.R280T	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148T|TP53_uc010cng.1_Missense_Mutation_p.R148T|TP53_uc002gii.1_Missense_Mutation_p.R148T|TP53_uc010cnh.1_Missense_Mutation_p.R280T|TP53_uc010cni.1_Missense_Mutation_p.R280T|TP53_uc002gij.2_Missense_Mutation_p.R280T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			3	28					0	0	0	0	G	7577099	G	G	7577099	3	3	97	1	0	0	0	0	1	0	0	0	16448	913	32	2	447	2	TP53	17	7577099	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	172	7577099	73618111	141	18702											
NCOR1	9611	broad.mit.edu	37	chr17	16089965	16089965	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgatgcctgactcacttCaagatgagaggaacgataat	13	10	10	8	1	2	4	2	3	0	2	2	7	2	5	1	1	2	0	1	1	3	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:16089965C>T	uc002gpo.2	-	3	385	c.145G>A	c.(145-147)GAA>AAA	p.E49K	NCOR1_uc002gpn.2_Missense_Mutation_p.E49K|NCOR1_uc002gpp.1_Intron|NCOR1_uc002gpr.2_Intron|NCOR1_uc002gps.1_Missense_Mutation_p.E49K|NCOR1_uc010coz.1_5'UTR|NCOR1_uc010cpb.1_Missense_Mutation_p.E49K|NCOR1_uc010cpa.1_Missense_Mutation_p.E49K|NCOR1_uc002gpu.2_Missense_Mutation_p.E49K	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	49	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TGACTCACTTCAAGATGAGAG	0.408													6	80					0	0	0	0	T	16089965	T	T	16089965	3	4	97	1	0	0	0	0	1	0	0	0	10289	835	29	2	7353	2	NCOR1	17	16089965	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	8512866	16089965	65105245	142	18703											
LUC7L3	51747	broad.mit.edu	37	chr17	48827881	48827882	+	Frame_Shift_Ins	INS	-	A	A																															aaaagaggggatctgatgatINSaaaaaaagtagtgtgaagtc																										TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:48827881_48827882insA	uc002isr.2	+	10	1275_1276	c.1158_1159insA	c.(1156-1161)GATAAAfs	p.D386fs	LUC7L3_uc010wmw.1_Frame_Shift_Ins_p.D310fs|LUC7L3_uc002isq.2_Frame_Shift_Ins_p.D386fs|LUC7L3_uc002iss.2_Frame_Shift_Ins_p.D386fs|uc002ist.1_5'Flank	NM_006107	NP_006098	O95232	LC7L3_HUMAN	LUC7-like 3	386_387	Arg/Ser-rich.				apoptosis|mRNA processing|response to stress|RNA splicing	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding				0						GATCTGATGATAAAAAAAGTAG	0.356													---	---	---								A	48827882	A	A	48827881	7	5	97	1	0	1	1	0	0	0	0	0	9134	1403	49	0	1196	0	LUC7L3	17	48827881	Frame_Shift_Ins	INS	-	TCGA-CQ-5331-01A-02D-1870-08	32737916	48827881	32367329	143	18704											
MKS1	54903	broad.mit.edu	37	chr17	56289744	56289744	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccaagctactcaccatctCaaagtcggtgcctacgaggc	11	7	9	14	2	2	0	2	0	1	0	4	1	2	0	3	2	5	1	3	2	4	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:56289744C>G	uc002ivr.1	-	9	985	c.910G>C	c.(910-912)GAG>CAG	p.E304Q	MKS1_uc010wnq.1_Missense_Mutation_p.E101Q|MKS1_uc002ivs.1_Missense_Mutation_p.E304Q	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	304					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1						CTCACCATCTCAAAGTCGGTG	0.502													18	84					0	0	0	0	G	56289744	G	G	56289744	3	3	97	1	0	0	0	0	1	0	0	0	9662	835	29	2	809	2	MKS1	17	56289744	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	7461863	56289744	24905466	144	18705											
LPO	4025	broad.mit.edu	37	chr17	56345268	56345268	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtcccacgggacccattCtgggccaacagctaccccta	10	6	9	16	1	1	0	0	0	1	0	2	1	2	1	5	3	3	1	5	3	4	3	rs3744104		TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:56345268C>T	uc002ivt.2	+	13	2368	c.2052C>T	c.(2050-2052)TTC>TTT	p.F684F	LPO_uc010wns.1_Silent_p.F625F|LPO_uc010dcp.2_Silent_p.F601F|LPO_uc010dcq.2_Silent_p.F355F|LPO_uc010dcr.2_Silent_p.F247F	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	684					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						GGGACCCATTCTGGGCCAACA	0.572													18	104					0	0	0	0	T	56345268	T	T	56345268	2	4	97	1	0	0	0	0	0	0	0	1	8972	912	32	2		2	LPO	17	56345268	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	55524	56345268	24849942	145	18706											
ICAM2	3384	broad.mit.edu	37	chr17	62081150	62081150	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgtggctgtggcctcctgcGgagcaggggctgccttcccg	3	9	16	13	2	0	0	0	0	0	0	2	1	2	1	4	5	3	3	4	5	0	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:62081150G>A	uc002jdu.3	-	3	735	c.503C>T	c.(502-504)CCG>CTG	p.P168L	C17orf72_uc002jdt.3_3'UTR|C17orf72_uc010wpu.1_3'UTR|C17orf72_uc010wpv.1_3'UTR|C17orf72_uc010wpw.1_3'UTR|ICAM2_uc002jdw.3_Missense_Mutation_p.P168L|ICAM2_uc010ded.2_Missense_Mutation_p.P168L|ICAM2_uc002jdx.3_Missense_Mutation_p.P168L|ICAM2_uc002jdv.3_Missense_Mutation_p.P168L	NM_000873	NP_000864	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2 precursor	168	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			ovary(1)	1						GGCCTCCTGCGGAGCAGGGGC	0.627													16	74					0	0	0	0	A	62081150	A	A	62081150	3	1	97	1	0	0	0	0	1	0	0	0	7519	1116	39	1	332	1	ICAM2	17	62081150	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	5735882	62081150	19114060	146	18707											
AXIN2	8313	broad.mit.edu	37	chr17	63537611	63537611	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttggccattggccttcaCactgcgatgcatttctctct	6	14	7	14	1	3	0	1	0	2	0	4	1	3	0	2	2	2	1	2	2	0	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:63537611C>A	uc002jfi.2	-	4	1310	c.1021G>T	c.(1021-1023)GTG>TTG	p.V341L	AXIN2_uc010den.1_Missense_Mutation_p.V341L|AXIN2_uc002jfh.2_Missense_Mutation_p.V341L	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	341	Interaction with GSK3B (By similarity).				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						TTGGCCTTCACACTGCGATGC	0.473									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				15	117					5.35267e-07	5.72549e-07	1	0	A	63537611	A	A	63537611	3	1	97	1	0	0	0	0	1	0	0	0	1239	478	17	4	1542	4	AXIN2	17	63537611	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	1456461	63537611	17657599	147	18708											
APOH	350	broad.mit.edu	37	chr17	64216816	64216816	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctgatggcttataaacacGaagtgttgcaaacgtaggta	14	10	11	6	2	0	1	0	1	0	0	0	2	0	1	0	2	4	6	0	2	7	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:64216816G>A	uc002jfn.3	-	5	519	c.460C>T	c.(460-462)CGT>TGT	p.R154C		NM_000042	NP_000033	P02749	APOH_HUMAN	apolipoprotein H precursor	154	Sushi 3.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding				0			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			TTATAAACACGAAGTGTTGCA	0.383													14	96					0	0	0	0	A	64216816	A	A	64216816	3	1	97	1	0	0	0	0	1	0	0	0	804	1058	37	1	593	1	APOH	17	64216816	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	679205	64216816	16978394	148	18709											
NPTX1	4884	broad.mit.edu	37	chr17	78444754	78444754	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtacacctccccgggggtCagcttgcggtcccagatgtt	5	11	12	13	2	1	1	1	0	0	1	3	1	3	1	4	3	3	3	4	3	1	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr17:78444754C>T	uc002jyp.1	-	5	1316	c.1158G>A	c.(1156-1158)CTG>CTA	p.L386L		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	neuronal pentraxin I precursor	386	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			CCCCGGGGGTCAGCTTGCGGT	0.592													14	84					0	0	0	0	T	78444754	T	T	78444754	2	4	97	1	0	0	0	0	0	0	0	1	10656	813	29	2		2	NPTX1	17	78444754	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	14227938	78444754	2750456	149	18710											
ARHGAP28	79822	broad.mit.edu	37	chr18	6890002	6890002	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcagtagaagcaaacactCtgattatgaagaattactgt	15	12	7	7	0	2	4	1	2	1	2	2	4	2	4	0	0	3	2	0	0	7	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr18:6890002C>G	uc010wzi.1	+	12	1359	c.1121C>G	c.(1120-1122)TCT>TGT	p.S374C	ARHGAP28_uc002knc.2_Missense_Mutation_p.S499C|ARHGAP28_uc002knd.2_Missense_Mutation_p.S392C|ARHGAP28_uc002kne.2_Missense_Mutation_p.S392C|ARHGAP28_uc002knf.2_Missense_Mutation_p.S383C			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	374					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				AGCAAACACTCTGATTATGAA	0.398													12	85					0	0	0	0	G	6890002	G	G	6890002	3	3	97	1	0	0	0	0	1	0	0	0	877	913	32	2	1217	2	ARHGAP28	18	6890002	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		6890002	71187246	150	18711											
THEG	51298	broad.mit.edu	37	chr19	362264	362264	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgggggtggcaagctcataGaggcgaggggacgcctgtcg	7	7	19	8	3	1	1	1	0	0	1	2	3	1	2	1	6	1	2	1	6	2	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr19:362264G>A	uc002lol.2	-	8	1115	c.1076C>T	c.(1075-1077)TCT>TTT	p.S359F	THEG_uc002lom.2_Missense_Mutation_p.S335F	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1	359					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAGCTCATAGAGGCGAGGGG	0.602													24	152					0	0	0	0	A	362264	A	A	362264	3	1	97	1	0	0	0	0	1	0	0	0	15923	942	33	2	67	2	THEG	19	362264	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08		362264	58766719	151	18712											
HAUS8	93323	broad.mit.edu	37	chr19	17170416	17170416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgttgactcaggtttctttGatattgtttttgctaactgt	7	21	8	5	0	2	2	1	2	1	0	2	2	2	2	0	1	2	4	0	1	2	8			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr19:17170416G>A	uc002nfe.2	-	6	482	c.371C>T	c.(370-372)TCA>TTA	p.S124L	HAUS8_uc002nff.2_Missense_Mutation_p.S123L|HAUS8_uc002nfg.1_Missense_Mutation_p.S63L|HAUS8_uc002nfh.1_Missense_Mutation_p.S124L	NM_033417	NP_219485	Q9BT25	HAUS8_HUMAN	sarcoma antigen NY-SAR-48 isoform a	124					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0						AGGTTTCTTTGATATTGTTTT	0.428													13	78					0	0	0	0	A	17170416	A	A	17170416	3	1	97	1	0	0	0	0	1	0	0	0	7011	1294	45	2	885	2	HAUS8	19	17170416	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	16808152	17170416	41958567	152	18713											
ZNF208	7757	broad.mit.edu	37	chr19	22154039	22154039	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttatgtttactgaagactGataaccagctgaaggctttg	11	14	9	7	0	1	4	0	3	1	1	1	4	1	4	1	1	3	3	1	1	5	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr19:22154039G>C	uc002nqp.2	-	6	3562	c.3413C>G	c.(3412-3414)TCA>TGA	p.S1138*	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACTGAAGACTGATAACCAGCT	0.388													6	56					0	0	0	0	C	22154039	C	C	22154039	4	2	97	1	0	0	0	0	0	1	0	0	17833	1294	45	2	49	2	ZNF208	19	22154039	Nonsense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	4983623	22154039	36974944	153	18714											
RYR1	6261	broad.mit.edu	37	chr19	38959733	38959733	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caatggcgaggtcctcatgtCtgactcaggctccgaaacag	10	8	11	12	2	3	1	2	1	1	0	5	3	5	1	2	3	1	1	2	3	2	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr19:38959733C>G	uc002oit.2	+	26	3639	c.3509C>G	c.(3508-3510)TCT>TGT	p.S1170C	RYR1_uc002oiu.2_Missense_Mutation_p.S1170C	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1170	6 X approximate repeats.|Cytoplasmic.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTCCTCATGTCTGACTCAGGC	0.468													10	100					0	0	0	0	G	38959733	G	G	38959733	3	3	97	1	0	0	0	0	1	0	0	0	13833	913	32	2	3611	2	RYR1	19	38959733	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	16805694	38959733	20169250	154	18715											
ZNF221	7638	broad.mit.edu	37	chr19	44470712	44470712	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttcgtcagagatcagcacTtaatagtcattccatggtcc	10	13	7	11	1	3	1	3	0	0	1	6	2	5	1	2	1	1	1	2	1	2	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr19:44470712T>A	uc002oxx.2	+	6	1386	c.1058T>A	c.(1057-1059)CTT>CAT	p.L353H	ZNF221_uc010ejb.1_Missense_Mutation_p.L353H|ZNF221_uc010xws.1_Missense_Mutation_p.L353H	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	353	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				AGATCAGCACTTAATAGTCAT	0.403													18	121					0	0	0	0	A	44470712	A	A	44470712	3	1	97	1	0	0	0	0	1	0	0	0	17842	1609	56	5	1072	5	ZNF221	19	44470712	Missense_Mutation	SNP	T	TCGA-CQ-5331-01A-02D-1870-08	5510979	44470712	14658271	155	18716											
SNRNP70	6625	broad.mit.edu	37	chr19	49610936	49610936	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatgtgaacatccggcattCaggccgcgatgacacctccc	9	8	10	14	3	1	3	1	3	0	0	3	4	3	3	4	2	1	1	4	2	1	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr19:49610936C>T	uc002pmk.2	+	9	1071	c.632C>T	c.(631-633)TCA>TTA	p.S211L	SNRNP70_uc002pmh.1_RNA|SNRNP70_uc002pmi.1_Missense_Mutation_p.S211L|SNRNP70_uc002pml.2_5'UTR|SNRNP70_uc002pmm.2_RNA	NM_003089	NP_003080	P08621	RU17_HUMAN	U1 small nuclear ribonucleoprotein 70 kDa	211					nuclear mRNA splicing, via spliceosome|regulation of RNA splicing	nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						ATCCGGCATTCAGGCCGCGAT	0.657													12	63					0	0	0	0	T	49610936	T	T	49610936	3	4	97	1	0	0	0	0	1	0	0	0	14922	838	29	2	662	2	SNRNP70	19	49610936	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	5140224	49610936	9518047	156	18717											
LILRB3	11025	broad.mit.edu	37	chr19	54724540	54724540	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcctggtacttatgagctccGtacattgatctcagacgcag	9	11	10	11	2	1	3	1	2	1	1	3	3	2	3	2	1	3	4	2	1	3	4			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr19:54724540G>A	uc002qef.1	-	6	1227	c.1116C>T	c.(1114-1116)TAC>TAT	p.Y372Y	LILRB3_uc002qee.1_Silent_p.Y372Y|LILRB3_uc002qeh.1_Silent_p.Y372Y|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Silent_p.Y372Y|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Silent_p.Y372Y|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Silent_p.Y372Y|LILRB3_uc002qep.1_Silent_p.Y372Y|LILRB3_uc002qeq.1_Silent_p.Y372Y|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Silent_p.Y372Y|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	372	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity	p.Y372Y(1)		skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TATGAGCTCCGTACATTGATC	0.567													20	49					0	0	0	0	A	54724540	A	A	54724540	2	1	97	1	0	0	0	0	0	0	0	1	8833	1140	40	1		1	LILRB3	19	54724540	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	5113604	54724540	4404443	157	18718											
ACSS1	84532	broad.mit.edu	37	chr20	24989982	24989982	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcctgcaccaccacatctGagtcacccgcactatctttc	8	10	5	18	1	3	1	1	1	2	0	5	1	4	1	4	0	1	3	4	0	1	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr20:24989982G>C	uc002wub.2	-	13	2692	c.1814C>G	c.(1813-1815)TCA>TGA	p.S605*	ACSS1_uc002wuc.2_Nonsense_Mutation_p.S603*|ACSS1_uc010gdc.2_Nonsense_Mutation_p.S400*|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Nonsense_Mutation_p.S522*	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	605					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CACCACATCTGAGTCACCCGC	0.502													36	190					0	0	0	0	C	24989982	C	C	24989982	4	2	97	1	0	0	0	0	0	1	0	0	188	1294	45	2	263	2	ACSS1	20	24989982	Nonsense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08		24989982	38035538	158	18719											
UBASH3A	53347	broad.mit.edu	37	chr21	43862566	43862566	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attctgttgaatccagaactCaaactggagaaaaaaatcaa	19	9	6	7	0	3	3	2	1	1	2	4	4	4	3	1	1	2	1	1	1	7	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr21:43862566C>G	uc002zbe.2	+	12	1527	c.1491C>G	c.(1489-1491)CTC>CTG	p.L497L	UBASH3A_uc002zbf.2_Silent_p.L459L|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Silent_p.L459L	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	497	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						ATCCAGAACTCAAACTGGAGA	0.428													19	113					0	0	0	0	G	43862566	G	G	43862566	2	3	97	1	0	0	0	0	0	0	0	1	16907	813	29	2		2	UBASH3A	21	43862566	Silent	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		43862566	4267329	159	18720											
DGCR6L	85359	broad.mit.edu	37	chr22	20307265	20307265	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atttcgaacacggtgccgtcGagaagcgccagggccaggtc	9	6	14	12	5	0	1	0	0	0	1	3	3	0	1	3	3	3	0	3	3	2	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr22:20307265G>C	uc002zrx.2	-	2	265	c.168C>G	c.(166-168)CTC>CTG	p.L56L	DGCR6L_uc010gsb.2_RNA|DGCR6L_uc010gsc.2_Silent_p.L56L	NM_033257	NP_150282	Q9BY27	DGC6L_HUMAN	DiGeorge syndrome critical region gene 6 like	56						nucleus					0	Colorectal(54;0.0993)					CGGTGCCGTCGAGAAGCGCCA	0.652													6	22					0	0	0	0	C	20307265	C	C	20307265	2	2	97	1	0	0	0	0	0	0	0	1	4485	1045	37	3		3	DGCR6L	22	20307265	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08		20307265	30997301	160	18721											
CSNK1E	1454	broad.mit.edu	37	chr22	38698935	38698935	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagaagttgaacaggtcctcGaggctaggccccagcagctc	10	6	12	13	1	0	2	0	1	0	1	3	3	1	2	3	3	3	4	3	3	3	2			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr22:38698935G>C	uc003avj.2	-	4	528	c.267C>G	c.(265-267)CTC>CTG	p.L89L	CSNK1E_uc003avk.2_Silent_p.L89L|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Silent_p.L89L|CSNK1E_uc003avo.2_Silent_p.L89L|CSNK1E_uc003avp.1_Silent_p.L89L|CSNK1E_uc003avq.1_Silent_p.L89L|LOC400927_uc010gxm.2_RNA	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	89	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)					ACAGGTCCTCGAGGCTAGGCC	0.622													16	89					0	0	0	0	C	38698935	C	C	38698935	2	2	97	1	0	0	0	0	0	0	0	1	3970	1045	37	3		3	CSNK1E	22	38698935	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	18391670	38698935	12605631	161	18722											
EP300	2033	broad.mit.edu	37	chr22	41556666	41556666	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtatcatttctgtgagaagtGtttcaatgagatccaagggg	11	13	12	5	0	3	2	2	2	1	2	4	4	4	2	1	2	0	2	1	2	4	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chr22:41556666G>A	uc003azl.3	+	20	4006	c.3611G>A	c.(3610-3612)TGT>TAT	p.C1204Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1204					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.Y1198_L1243del(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGTGAGAAGTGTTTCAATGAG	0.468			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				19	85					0	0	0	0	A	41556666	A	A	41556666	3	1	97	1	0	0	0	0	1	0	0	0	5172	1377	48	4	3689	4	EP300	22	41556666	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	2857731	41556666	9747900	162	18723											
DMD	1756	broad.mit.edu	37	chrX	31986458	31986458	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagatctgtcgccctacctCttttttctgtctgacagctg	5	17	7	12	1	4	2	0	1	4	1	5	2	4	2	2	0	2	1	2	0	2	5			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chrX:31986458C>G	uc004dda.1	-	45	6856	c.6612G>C	c.(6610-6612)AAG>AAC	p.K2204N	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.K860N|DMD_uc004dcx.2_Missense_Mutation_p.K863N|DMD_uc004dcz.2_Missense_Mutation_p.K2081N|DMD_uc004dcy.1_Missense_Mutation_p.K2200N|DMD_uc004ddb.1_Missense_Mutation_p.K2196N|DMD_uc010ngo.1_Missense_Mutation_p.K113N|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2204	Spectrin 15.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CGCCCTACCTCTTTTTTCTGT	0.398													17	180					0	0	0	0	G	31986458	G	G	31986458	3	3	97	1	0	0	0	0	1	0	0	0	4602	912	32	2	4733	2	DMD	23	31986458	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08		31986458	123284102	163	18724											
ZNF182	7569	broad.mit.edu	37	chrX	47837082	47837082	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccaaactcatgacagtcaCgagcactcttggtgataatt	12	12	7	10	1	3	2	2	2	1	0	4	3	4	2	1	1	2	1	1	1	2	4	rs140603964		TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chrX:47837082C>G	uc004dir.2	-	7	750	c.404G>C	c.(403-405)CGT>CCT	p.R135P	ZNF182_uc004dis.2_Missense_Mutation_p.R116P|ZNF182_uc004dit.2_Missense_Mutation_p.R135P|ZNF182_uc011mlu.1_Missense_Mutation_p.R115P	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						ATGACAGTCACGAGCACTCTT	0.378													14	85					0	0	0	0	G	47837082	G	G	47837082	3	3	97	1	0	0	0	0	1	0	0	0	17817	536	19	3	1519	3	ZNF182	23	47837082	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	15850624	47837082	107433478	164	18725											
TBC1D25	4943	broad.mit.edu	37	chrX	48417355	48417355	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgacgtgttgctggctgaGaaacggtcatcactgacgac	9	9	12	11	4	2	2	2	2	0	1	3	5	3	2	1	2	2	3	1	2	1	1			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chrX:48417355G>C	uc004dka.1	+	4	570	c.459G>C	c.(457-459)GAG>GAC	p.E153D	TBC1D25_uc011mly.1_Missense_Mutation_p.E95D|TBC1D25_uc004dkb.1_5'UTR|TBC1D25_uc011mlz.1_5'UTR|TBC1D25_uc011mma.1_Intron|TBC1D25_uc004dkc.1_5'UTR|TBC1D25_uc011mmb.1_Missense_Mutation_p.E157D|TBC1D25_uc011mmc.1_5'UTR|TBC1D25_uc011mmd.1_Intron	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	153						intracellular	Rab GTPase activator activity			ovary(1)	1						TGCTGGCTGAGAAACGGTCAT	0.537													6	68					0	0	0	0	C	48417355	C	C	48417355	3	2	97	1	0	0	0	0	1	0	0	0	15681	933	33	2	473	2	TBC1D25	23	48417355	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	580273	48417355	106853205	165	18726											
FAM123B	139285	broad.mit.edu	37	chrX	63412536	63412536	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcagggcacctgaggggCtgagctcacgtgctcatgag	10	6	15	10	1	2	3	2	3	0	0	2	3	2	3	1	3	3	5	1	3	1	0			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chrX:63412536C>A	uc004dvo.2	-	2	904	c.631G>T	c.(631-633)GCC>TCC	p.A211S		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	211					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						ACCTGAGGGGCTGAGCTCACG	0.597													13	89					1.49906e-05	1.57989e-05	1	0	A	63412536	A	A	63412536	3	1	97	1	0	0	0	0	1	0	0	0	5451	797	28	4	2780	4	FAM123B	23	63412536	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	14995181	63412536	91858024	166	18727											
MED12	9968	broad.mit.edu	37	chrX	70346843	70346843	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaatgaactgagtgtagttGaggctgagctgcttctcaaa	11	12	12	6	0	1	5	1	5	1	0	2	5	1	5	0	1	3	5	0	1	4	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chrX:70346843G>C	uc004dyy.2	+	20	2909	c.2710G>C	c.(2710-2712)GAG>CAG	p.E904Q	MED12_uc011mpq.1_Missense_Mutation_p.E904Q|MED12_uc004dyz.2_Missense_Mutation_p.E904Q|MED12_uc004dza.2_Missense_Mutation_p.E751Q|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	904					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GAGTGTAGTTGAGGCTGAGCT	0.542													10	102					0	0	0	0	C	70346843	C	C	70346843	3	2	97	1	0	0	0	0	1	0	0	0	9481	1291	45	2	2788	2	MED12	23	70346843	Missense_Mutation	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	6934307	70346843	84923717	167	18728											
NAP1L2	4674	broad.mit.edu	37	chrX	72433878	72433878	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcattgatgatctgacgtcTtttttccagtaagggttggt	7	17	11	6	1	2	3	0	3	2	0	3	3	3	3	1	2	1	3	1	2	1	6			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chrX:72433878T>C	uc004ebi.2	-	1	807	c.451A>G	c.(451-453)AGA>GGA	p.R151G	NAP1L2_uc011mqj.1_Missense_Mutation_p.R9G	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	151					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					ATCTGACGTCTTTTTTCCAGT	0.383													3	205					0	0	0	0	C	72433878	C	C	72433878	3	2	97	1	0	0	0	0	1	0	0	0	10210	1617	56	5	935	5	NAP1L2	23	72433878	Missense_Mutation	SNP	T	TCGA-CQ-5331-01A-02D-1870-08	2087035	72433878	82836682	168	18729											
MAGEC1	9947	broad.mit.edu	37	chrX	140996182	140996182	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagggcatgtcccagaacCgcctcctgattcttattctg	8	11	9	13	1	2	2	0	1	2	1	4	2	4	2	4	1	2	2	4	1	2	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chrX:140996182C>A	uc004fbt.2	+	4	3278	c.2992C>A	c.(2992-2994)CGC>AGC	p.R998S	MAGEC1_uc010nsl.1_Missense_Mutation_p.R65S	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	998	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GTCCCAGAACCGCCTCCTGAT	0.512										HNSCC(15;0.026)			20	185					2.37509e-13	2.6876e-13	1	0	A	140996182	A	A	140996182	3	1	97	1	0	0	0	0	1	0	0	0	9233	652	23	3	2998	3	MAGEC1	23	140996182	Missense_Mutation	SNP	C	TCGA-CQ-5331-01A-02D-1870-08	68562304	140996182	14274378	169	18730											
FAM3A	60343	broad.mit.edu	37	chrX	153735817	153735817	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataaacttcaacaggtcgttGacatctgggggggcaggtgc	10	9	14	8	1	2	1	1	1	1	0	3	1	2	1	0	5	3	2	0	5	3	3			TCGA-CQ-5331-01A-02D-1870-08	TCGA-CQ-5331-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d2c2d3db-dbc0-44f1-b625-17f3f819c122	9aeca350-ffd8-4c58-a7b9-0bc09da94ca1	g.chrX:153735817G>C	uc004fls.1	-	7	667	c.390C>G	c.(388-390)GTC>GTG	p.V130V	FAM3A_uc004flt.1_Silent_p.V144V|FAM3A_uc011mzp.1_Silent_p.V113V|FAM3A_uc004flu.1_Silent_p.V127V|FAM3A_uc011mzq.1_Silent_p.V130V|FAM3A_uc004flw.1_Silent_p.V130V	NM_021806	NP_068578	P98173	FAM3A_HUMAN	family 3, member A protein precursor	130						extracellular region				large_intestine(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACAGGTCGTTGACATCTGGGG	0.582													7	31					0	0	0	0	C	153735817	C	C	153735817	2	2	97	1	0	0	0	0	0	0	0	1	5588	1277	45	2		2	FAM3A	23	153735817	Silent	SNP	G	TCGA-CQ-5331-01A-02D-1870-08	12739635	153735817	1534743	170	18731											
CAMTA1	23261	broad.mit.edu	37	chr1	7724919	7724919	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttgacatctccttcagcaAccagttctccgacctgatca	9	12	5	15	1	4	2	2	2	2	0	6	3	4	2	4	0	2	2	4	0	1	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:7724919A>T	uc001aoi.2	+	9	2519	c.2312A>T	c.(2311-2313)AAC>ATC	p.N771I		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	771					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCCTTCAGCAACCAGTTCTCC	0.627													141	77					0	0	0	0	T	7724919	T	T	7724919	3	4	98	1	0	0	0	0	1	0	0	0	2625	43	2	5	2346	5	CAMTA1	1	7724919	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08		7724919	241525702	1	18732											
SERINC2	347735	broad.mit.edu	37	chr1	31896555	31896555	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcaggcgtcctgcctctgcGgctctgccccctgcatcctg	2	9	11	19	3	2	0	0	0	2	0	4	0	4	0	5	2	4	3	5	2	0	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:31896555G>A	uc010ogh.1	+	2	268	c.67G>A	c.(67-69)GGC>AGC	p.G23S	SERINC2_uc010ogg.1_Missense_Mutation_p.G20S|SERINC2_uc009vtw.1_Missense_Mutation_p.G19S|SERINC2_uc001bst.2_Missense_Mutation_p.G19S|SERINC2_uc001bsu.2_5'UTR|SERINC2_uc001bsv.2_5'UTR	NM_178865	NP_849196	Q96SA4	SERC2_HUMAN	tumor differentially expressed 2-like	19	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0541)|READ - Rectum adenocarcinoma(331;0.151)		CTGCCTCTGCGGCTCTGCCCC	0.677													43	10					0	0	0	0	A	31896555	A	A	31896555	3	1	98	1	0	0	0	0	1	0	0	0	14145	1116	39	1	61	1	SERINC2	1	31896555	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	24171636	31896555	217354066	2	18733											
ZMYM1	79830	broad.mit.edu	37	chr1	35580081	35580081	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagcttcaaaataaaaccAtagacattttttctttgtct	15	15	4	7	0	3	2	1	0	2	2	3	2	3	2	1	0	2	1	1	0	6	7			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:35580081A>G	uc001bym.2	+	11	2798	c.2650A>G	c.(2650-2652)ATA>GTA	p.I884V	ZMYM1_uc001byn.2_Missense_Mutation_p.I884V|ZMYM1_uc010ohu.1_Missense_Mutation_p.I865V|ZMYM1_uc001byo.2_Missense_Mutation_p.I524V|ZMYM1_uc009vut.2_Missense_Mutation_p.I809V	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	884						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAATAAAACCATAGACATTTT	0.313													13	7					0	0	0	0	G	35580081	G	G	35580081	3	3	98	1	0	0	0	0	1	0	0	0	17766	217	8	5	2684	5	ZMYM1	1	35580081	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	3683526	35580081	213670540	3	18734											
HIST2H2BE	8349	broad.mit.edu	37	chr1	149858147	149858147	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctttggtgacggctttcttgGagccctttttaggggccgga	4	14	14	9	2	1	1	0	1	1	0	1	3	1	3	2	6	1	1	2	6	1	6			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:149858147G>C	uc001etc.2	-	1	86	c.44C>G	c.(43-45)TCC>TGC	p.S15C	HIST2H2AC_uc001etd.2_5'Flank	NM_003528	NP_003519	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	15					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGCTTTCTTGGAGCCCTTTTT	0.537													37	63					0	0	0	0	C	149858147	C	C	149858147	3	2	98	1	0	0	0	0	1	0	0	0	7218	1174	41	2	340	2	HIST2H2BE	1	149858147	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	114278066	149858147	99392474	4	18735											
LINGO4	339398	broad.mit.edu	37	chr1	151774826	151774826	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggccccatgattctgagccGattgccctgcagcctcaggg	7	8	12	14	1	2	2	1	2	1	0	2	3	2	2	5	2	4	1	5	2	0	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:151774826G>A	uc001ezf.1	-	2	545	c.355C>T	c.(355-357)CGG>TGG	p.R119W		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	119	LRR 3.|Extracellular (Potential).					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ATTCTGAGCCGATTGCCCTGC	0.577													17	109					0	0	0	0	A	151774826	A	A	151774826	3	1	98	1	0	0	0	0	1	0	0	0	8859	1057	37	1	1430	1	LINGO4	1	151774826	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	1916679	151774826	97475795	5	18736											
IGSF9	57549	broad.mit.edu	37	chr1	159904572	159904572	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaacatcctgggaggcattGactgtgctgttcttgggggg	7	11	16	7	0	1	1	0	1	1	0	2	3	2	2	1	5	2	3	1	5	1	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:159904572G>A	uc001fur.2	-	7	912	c.714C>T	c.(712-714)GTC>GTT	p.V238V	IGSF9_uc001fuq.2_Silent_p.V238V|IGSF9_uc001fup.2_5'Flank	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	238	Ig-like 3.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GGGAGGCATTGACTGTGCTGT	0.562													6	65					0	0	0	0	A	159904572	A	A	159904572	2	1	98	1	0	0	0	0	0	0	0	1	7644	1277	45	2		2	IGSF9	1	159904572	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	8129746	159904572	89346049	6	18737											
C1orf9	51430	broad.mit.edu	37	chr1	172555026	172555026	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatatctgagaatgccacTgccacagctgcacctaaaat	14	9	7	11	0	1	1	0	1	1	1	1	2	1	1	3	0	4	3	3	0	5	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:172555026T>G	uc001giq.3	+	17	1912	c.1596T>G	c.(1594-1596)ACT>ACG	p.T532T	C1orf9_uc010pmm.1_Silent_p.T532T|C1orf9_uc009wwd.2_Silent_p.T488T|C1orf9_uc010pmn.1_Silent_p.T495T|C1orf9_uc010pmo.1_Intron	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	532					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		AGAATGCCACTGCCACAGCTG	0.244													62	143					0	0	0	0	G	172555026	G	G	172555026	2	3	98	1	0	0	0	0	0	0	0	1	2077	1567	55	5		5	C1orf9	1	172555026	Silent	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	12650454	172555026	76695595	7	18738											
NPHS2	7827	broad.mit.edu	37	chr1	179544828	179544828	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccgtggcggcgggcgctcGgggctcccccggggtccccg	1	4	18	18	7	0	0	0	0	0	0	3	0	2	0	5	7	0	2	5	7	0	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:179544828G>C	uc001gmq.3	-	1	257	c.172C>G	c.(172-174)CGA>GGA	p.R58G	NPHS2_uc009wxi.2_Missense_Mutation_p.R58G	NM_014625	NP_055440	Q9NP85	PODO_HUMAN	podocin	58	Cytoplasmic (Potential).				excretion	integral to plasma membrane	protein binding				0						GCGGGCGCTCGGGGCTCCCCC	0.776													5	11					0	0	0	0	C	179544828	C	C	179544828	3	2	98	1	0	0	0	0	1	0	0	0	10637	1124	39	3	1011	3	NPHS2	1	179544828	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	6989802	179544828	69705793	8	18739											
CENPF	1063	broad.mit.edu	37	chr1	214825109	214825109	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgaagaagagcctagattgCatgcacaaagaccaggtgga	15	7	12	7	0	0	5	0	1	0	4	0	6	0	6	2	2	3	2	2	2	4	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:214825109C>T	uc001hkm.2	+	15	8214	c.8040C>T	c.(8038-8040)TGC>TGT	p.C2680C		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2776	Potential.|Sufficient for self-association.|Sufficient for centromere localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GCCTAGATTGCATGCACAAAG	0.388													18	36					0	0	0	0	T	214825109	T	T	214825109	2	4	98	1	0	0	0	0	0	0	0	1	3246	718	25	4		4	CENPF	1	214825109	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	35280281	214825109	34425512	9	18740											
KCTD3	51133	broad.mit.edu	37	chr1	215775490	215775490	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaactgaactgtatcatgAtccttcaaatgatgctatta	13	15	6	7	0	2	3	2	3	0	0	3	3	3	3	1	0	3	3	1	0	6	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:215775490A>T	uc001hks.2	+	12	1379	c.1085A>T	c.(1084-1086)GAT>GTT	p.D362V	KCTD3_uc001hkt.2_Missense_Mutation_p.D362V|KCTD3_uc010pub.1_Missense_Mutation_p.D260V|KCTD3_uc009xdn.2_Missense_Mutation_p.D114V	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	362						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		CTGTATCATGATCCTTCAAAT	0.303													19	45					0	0	0	0	T	215775490	T	T	215775490	3	4	98	1	0	0	0	0	1	0	0	0	8149	333	12	5	1131	5	KCTD3	1	215775490	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	950381	215775490	33475131	10	18741											
KCTD3	51133	broad.mit.edu	37	chr1	215792410	215792410	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggttaacaaaagtgaagataAgggtaggttctcatacagaa	17	9	11	4	0	1	3	1	1	1	2	2	3	1	3	0	3	2	3	0	3	8	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:215792410A>G	uc001hks.2	+	16	2039	c.1745A>G	c.(1744-1746)AAG>AGG	p.K582R	KCTD3_uc001hkt.2_Missense_Mutation_p.K582R|KCTD3_uc010pub.1_Missense_Mutation_p.K480R|KCTD3_uc009xdn.2_Missense_Mutation_p.K306R	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	582						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		AGTGAAGATAAGGGTAGGTTC	0.393													19	69					0	0	0	0	G	215792410	G	G	215792410	3	3	98	1	0	0	0	0	1	0	0	0	8149	72	3	5	1807	5	KCTD3	1	215792410	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	16920	215792410	33458211	11	18742											
SIPA1L2	57568	broad.mit.edu	37	chr1	232561495	232561495	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcctgttgctgcagatgctCtcgtcagacagcgtgcggta	6	11	12	12	3	2	2	1	0	1	2	4	2	3	2	1	1	5	5	1	1	1	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:232561495C>G	uc001hvg.2	-	16	4628	c.4470G>C	c.(4468-4470)GAG>GAC	p.E1490D	SIPA1L2_uc001hvf.2_Missense_Mutation_p.E564D	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1490					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TGCAGATGCTCTCGTCAGACA	0.552													7	20					0	0	0	0	G	232561495	G	G	232561495	3	3	98	1	0	0	0	0	1	0	0	0	14395	912	32	2	722	2	SIPA1L2	1	232561495	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	16769085	232561495	16689126	12	18743											
PCNXL2	80003	broad.mit.edu	37	chr1	233394939	233394939	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctttcctttaccattgatGagagtttctgtggcaactgg	7	16	9	9	0	1	2	0	2	1	1	3	3	3	2	3	2	2	2	3	2	2	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:233394939G>A	uc001hvl.2	-	5	904	c.669C>T	c.(667-669)CTC>CTT	p.L223L	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	223						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TACCATTGATGAGAGTTTCTG	0.498													12	111					0	0	0	0	A	233394939	A	A	233394939	2	1	98	1	0	0	0	0	0	0	0	1	11646	1277	45	2		2	PCNXL2	1	233394939	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	833444	233394939	15855682	13	18744											
EDARADD	128178	broad.mit.edu	37	chr1	236572548	236572548	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaaccagtggaagacacaGaccctagcactttatccttt	13	9	8	11	0	0	2	0	0	0	2	1	4	1	4	3	2	2	1	3	2	4	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr1:236572548G>A	uc001hxu.1	+	2	159	c.94G>A	c.(94-96)GAC>AAC	p.D32N	EDARADD_uc001hxv.1_Missense_Mutation_p.D22N	NM_145861	NP_665860	Q8WWZ3	EDAD_HUMAN	EDAR-associated death domain isoform A	32					cell differentiation|signal transduction	cytoplasm					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.0232)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			GGAAGACACAGACCCTAGCAC	0.308													24	55					0	0	0	0	A	236572548	A	A	236572548	3	1	98	1	0	0	0	0	1	0	0	0	4928	942	33	2	135	2	EDARADD	1	236572548	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	3177609	236572548	12678073	14	18745											
NLRC4	58484	broad.mit.edu	37	chr2	32476104	32476104	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactcagtggtagtggtgaCgatgaccatgttcttgaagc	9	11	13	8	1	2	3	1	3	1	0	2	4	2	3	1	2	1	3	1	2	2	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:32476104C>T	uc002roi.2	-	4	1075	c.829G>A	c.(829-831)GTC>ATC	p.V277I	NLRC4_uc002roj.1_Missense_Mutation_p.V277I|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	277	LRR 2.|NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GTAGTGGTGACGATGACCATG	0.522													54	88					0	0	0	0	T	32476104	T	T	32476104	3	4	98	1	0	0	0	0	1	0	0	0	10523	536	19	1	2269	1	NLRC4	2	32476104	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08		32476104	210723269	15	18746											
LTBP1	4052	broad.mit.edu	37	chr2	33500893	33500893	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgaatgcctgaggccggaCgtctgtggggaggggcactg	7	6	19	9	3	1	1	0	1	1	0	1	5	1	3	2	6	1	1	2	6	1	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:33500893C>G	uc002ros.2	+	18	2898	c.2898C>G	c.(2896-2898)GAC>GAG	p.D966E	LTBP1_uc002rot.2_Missense_Mutation_p.D640E|LTBP1_uc002rou.2_Missense_Mutation_p.D639E|LTBP1_uc002rov.2_Missense_Mutation_p.D586E|LTBP1_uc010ymz.1_Missense_Mutation_p.D639E|LTBP1_uc010yna.1_Missense_Mutation_p.D586E	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	965	EGF-like 6; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGAGGCCGGACGTCTGTGGGG	0.532													32	134					0	0	0	0	G	33500893	G	G	33500893	3	3	98	1	0	0	0	0	1	0	0	0	9123	535	19	3	3020	3	LTBP1	2	33500893	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	1024789	33500893	209698480	16	18747											
MTA3	57504	broad.mit.edu	37	chr2	42836652	42836652	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgacttgaccgataagcAgaaacatcagttgaaacata	16	8	9	8	1	1	4	1	3	0	1	1	5	1	4	1	1	3	3	1	1	4	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:42836652A>G	uc002rso.1	+	5	747	c.77A>G	c.(76-78)CAG>CGG	p.Q26R	MTA3_uc002rsp.1_Missense_Mutation_p.Q26R|MTA3_uc002rsq.2_Missense_Mutation_p.Q82R|MTA3_uc002rsr.2_Missense_Mutation_p.Q82R	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	82	BAH.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						ACCGATAAGCAGAAACATCAG	0.358													8	95					0	0	0	0	G	42836652	G	G	42836652	3	3	98	1	0	0	0	0	1	0	0	0	9963	188	7	5	259	5	MTA3	2	42836652	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	9335759	42836652	200362721	17	18748											
NRXN1	9378	broad.mit.edu	37	chr2	50318532	50318532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccaccactcctcgtgaaaCgaactacatggtatttccca	11	10	6	14	2	0	1	0	1	0	0	3	2	2	1	4	1	4	1	4	1	4	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:50318532C>T	uc010fbp.2	-	3	1349	c.542G>A	c.(541-543)CGT>CAT	p.R181H	NRXN1_uc002rxb.3_Missense_Mutation_p.R888H|NRXN1_uc010fbq.2_Missense_Mutation_p.R1256H|NRXN1_uc002rxe.3_Missense_Mutation_p.R1216H	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	181	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCTCGTGAAACGAACTACATG	0.473													69	193					0	0	0	0	T	50318532	T	T	50318532	3	4	98	1	0	0	0	0	1	0	0	0	10719	536	19	1	896	1	NRXN1	2	50318532	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	7481880	50318532	192880841	18	18749											
XPO1	7514	broad.mit.edu	37	chr2	61719576	61719576	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgatgcaataatagctttaTtatctttgcctcttttctgt	8	21	5	7	0	3	1	0	1	3	0	3	1	3	1	1	0	3	2	1	0	5	9			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:61719576T>G	uc002sbj.2	-	15	2335	c.1607A>C	c.(1606-1608)AAT>ACT	p.N536T	XPO1_uc010fcl.2_Missense_Mutation_p.N532T|XPO1_uc010ypn.1_Missense_Mutation_p.N532T|XPO1_uc002sbk.2_Missense_Mutation_p.N97T|XPO1_uc002sbh.2_Missense_Mutation_p.N183T	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	536	Necessary for HTLV-1 Rex-mediated mRNA export.|HEAT 4.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			AATAGCTTTATTATCTTTGCC	0.299													7	40					0	0	0	0	G	61719576	G	G	61719576	3	3	98	1	0	0	0	0	1	0	0	0	17513	1493	52	5	1652	5	XPO1	2	61719576	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	11401044	61719576	181479797	19	18750											
SNRNP200	23020	broad.mit.edu	37	chr2	96970578	96970578	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggtccggtcaatgagagaaCggtcagcttggagcacaaga	12	6	15	8	2	2	3	2	1	0	2	3	5	3	4	1	4	3	2	1	4	3	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:96970578C>T	uc002svu.2	-	2	160	c.74G>A	c.(73-75)CGT>CAT	p.R25H		NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	25						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						AATGAGAGAACGGTCAGCTTG	0.522													11	31					0	0	0	0	T	96970578	T	T	96970578	3	4	98	1	0	0	0	0	1	0	0	0	14916	536	19	1	6512	1	SNRNP200	2	96970578	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	35251002	96970578	146228795	20	18751											
C2orf40	84417	broad.mit.edu	37	chr2	106690370	106690370	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaactaagactaaagtggcCgttgatgagaataaagccaa	17	7	9	8	1	0	3	0	2	0	2	0	4	0	3	3	1	2	1	3	1	8	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:106690370C>T	uc010fjf.2	+	3	264	c.156C>T	c.(154-156)GCC>GCT	p.A52A		NM_032411	NP_115787	Q9H1Z8	AUGN_HUMAN	esophageal cancer related gene 4 protein	52						extracellular region|transport vesicle					0						CTAAAGTGGCCGTTGATGAGA	0.527													66	116					0	0	0	0	T	106690370	T	T	106690370	2	4	98	1	0	0	0	0	0	0	0	1	2175	639	23	1		1	C2orf40	2	106690370	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	9719792	106690370	136509003	21	18752											
UBXN4	23190	broad.mit.edu	37	chr2	136528287	136528287	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggcagctcgagaacgtatAaaacagcagattgcattggt	14	8	12	7	2	0	2	0	0	0	2	1	3	0	2	0	2	5	5	0	2	4	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:136528287A>G	uc002tur.2	+	8	1115	c.804A>G	c.(802-804)ATA>ATG	p.I268M	UBXN4_uc002tus.2_Missense_Mutation_p.I34M	NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	268	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						GAGAACGTATAAAACAGCAGA	0.373													13	14					0	0	0	0	G	136528287	G	G	136528287	3	3	98	1	0	0	0	0	1	0	0	0	16984	352	13	5	834	5	UBXN4	2	136528287	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	29837917	136528287	106671086	22	18753											
C2orf77	129881	broad.mit.edu	37	chr2	170510628	170510628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttccccatttgtataagacGcttttttgctttgatgaatt	8	20	6	7	1	0	3	0	2	0	1	1	3	1	3	2	0	1	3	2	0	3	9			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:170510628G>A	uc002ufe.2	-	6	1010	c.916C>T	c.(916-918)CGT>TGT	p.R306C		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	306	Potential.										0						TGTATAAGACGCTTTTTTGCT	0.323													6	12					0	0	0	0	A	170510628	A	A	170510628	3	1	98	1	0	0	0	0	1	0	0	0	2204	1087	38	1	758	1	C2orf77	2	170510628	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	33982341	170510628	72688745	23	18754											
TTN	7273	broad.mit.edu	37	chr2	179616133	179616133	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acatgtaatctgttttcttgGcagaactcattgtcttaaaa	12	16	6	7	0	4	1	1	0	3	1	4	1	4	1	0	1	1	3	0	1	4	6			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:179616133G>A	uc002unb.2	-	46	11218	c.10994C>T	c.(10993-10995)GCC>GTC	p.A3665V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTTTCTTGGCAGAACTCAT	0.363													176	45					0	0	0	0	A	179616133	A	A	179616133	3	1	98	1	0	0	0	0	1	0	0	0	16803	1203	42	4	99303	4	TTN	2	179616133	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	9105505	179616133	63583240	24	18755											
INO80D	54891	broad.mit.edu	37	chr2	206869901	206869901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtaaggccaacgttggctgGggcagagaactgcccctgga	10	6	15	10	1	0	1	0	0	0	1	0	3	0	2	3	5	3	4	3	5	3	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:206869901G>A	uc002vaz.3	-	11	2680	c.2275C>T	c.(2275-2277)CCA>TCA	p.P759S		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	759					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						ACGTTGGCTGGGGCAGAGAAC	0.557													25	39					0	0	0	0	A	206869901	A	A	206869901	3	1	98	1	0	0	0	0	1	0	0	0	7788	1232	43	4	812	4	INO80D	2	206869901	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	27253768	206869901	36329472	25	18756											
SLC4A3	6508	broad.mit.edu	37	chr2	220501041	220501041	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggagagaagaccgaggggCtgatgggcgtgtccgagctg	9	5	19	8	3	0	3	0	1	0	2	1	7	1	4	2	4	1	2	2	4	1	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr2:220501041C>A	uc002vmp.3	+	15	2478	c.2209C>A	c.(2209-2211)CTG>ATG	p.L737M	SLC4A3_uc002vmo.3_Missense_Mutation_p.L764M|SLC4A3_uc010fwm.2_Missense_Mutation_p.L287M|SLC4A3_uc010fwn.1_Missense_Mutation_p.L246M	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	737	Helical; (Potential).|Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GACCGAGGGGCTGATGGGCGT	0.617													46	31					1.35964e-18	1.52236e-18	1	0	A	220501041	A	A	220501041	3	1	98	1	0	0	0	0	1	0	0	0	14719	796	28	4	2344	4	SLC4A3	2	220501041	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	13631140	220501041	22698332	26	18757											
KLF15	28999	broad.mit.edu	37	chr3	126062647	126062647	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggagaggtggtcgctccGcgcgaacttcttctcgcaca	6	10	12	13	5	2	1	0	0	2	1	5	3	3	1	1	3	1	2	1	3	1	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr3:126062647G>A	uc011bkk.1	-	3	1356	c.1174C>T	c.(1174-1176)CGG>TGG	p.R392W		NM_014079	NP_054798	Q9UIH9	KLF15_HUMAN	Kruppel-like factor 15	392	C2H2-type 3.					nucleus	DNA binding|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(114;0.147)		TGGTCGCTCCGCGCGAACTTC	0.652													10	22					0	0	0	0	A	126062647	A	A	126062647	3	1	98	1	0	0	0	0	1	0	0	0	8382	1086	38	1	80	1	KLF15	3	126062647	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08		126062647	71959783	27	18758											
ZIC4	84107	broad.mit.edu	37	chr3	147114186	147114186	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggcctggggaggctcctcGtggaggcccgggaacaccga	7	4	18	12	3	0	0	0	0	0	0	2	5	1	3	4	7	1	1	4	7	1	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr3:147114186G>A	uc003ewd.1	-	3	414	c.141C>T	c.(139-141)CAC>CAT	p.H47H	ZIC4_uc003ewc.1_Translation_Start_Site|ZIC4_uc011bno.1_Silent_p.H97H	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	47						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GAGGCTCCTCGTGGAGGCCCG	0.672													14	25					0	0	0	0	A	147114186	A	A	147114186	2	1	98	1	0	0	0	0	0	0	0	1	17748	1136	40	1		1	ZIC4	3	147114186	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	21051539	147114186	50908244	28	18759											
SLC2A2	6514	broad.mit.edu	37	chr3	170716163	170716163	+	Missense_Mutation	SNP	T	A	A																															agatggctatcatgctcacaTaactcatccaagagaactta																										TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr3:170716163T>A	uc003fhe.1	-	10	1502	c.1193A>T	c.(1192-1194)TAT>TTT	p.Y398F	SLC2A2_uc003fhf.1_Missense_Mutation_p.Y225F|SLC2A2_uc011bpu.1_Missense_Mutation_p.Y271F	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	398	Extracellular (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			CATGCTCACATAACTCATCCA	0.433													15	23					0	0	0	0	A	170716163	A	A	170716163	3	1	98	1	0	0	0	0	1	0	0	0	14608	1406	49	5	389	5	SLC2A2	3	170716163	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	23601977	170716163	27306267	29	18760	38	2									
SLC2A2	6514	broad.mit.edu	37	chr3	170716165	170716165	+	Silent	SNP	A	G	G																															atggctatcatgctcacataActcatccaagagaacttatt																										TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr3:170716165A>G	uc003fhe.1	-	10	1500	c.1191T>C	c.(1189-1191)AGT>AGC	p.S397S	SLC2A2_uc003fhf.1_Silent_p.S224S|SLC2A2_uc011bpu.1_Silent_p.S270S	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	397	Extracellular (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			TGCTCACATAACTCATCCAAG	0.433													13	21					0	0	0	0	G	170716165	G	G	170716165	2	3	98	1	0	0	0	0	0	0	0	1	14608	40	2	5		5	SLC2A2	3	170716165	Silent	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	2	170716165	27306265	30	18761	38	2									
STK32B	55351	broad.mit.edu	37	chr4	5170173	5170173	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaccccttcctggtcaatCtgtggtgagtgtggctccat	6	12	11	12	0	2	1	1	1	1	0	4	1	4	1	4	3	1	2	4	3	1	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:5170173C>A	uc003gih.1	+	3	320	c.256C>A	c.(256-258)CTG>ATG	p.L86M	STK32B_uc010ida.1_Missense_Mutation_p.L39M	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	86	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						CCTGGTCAATCTGTGGTGAGT	0.552													6	13					3.59834e-05	3.70738e-05	1	0	A	5170173	A	A	5170173	3	1	98	1	0	0	0	0	1	0	0	0	15364	912	32	2	266	2	STK32B	4	5170173	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08		5170173	185984103	31	18762											
KIAA1211	57482	broad.mit.edu	37	chr4	57182512	57182512	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaccccggctccggagcaCgacaaggcagcaaacaaaat	15	2	10	14	3	0	1	0	0	0	1	1	3	1	2	3	3	3	4	3	3	4	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:57182512C>T	uc003hbk.2	+	8	3235	c.2844C>T	c.(2842-2844)CAC>CAT	p.H948H	KIAA1211_uc010iha.2_Silent_p.H941H|KIAA1211_uc011bzz.1_Silent_p.H858H|KIAA1211_uc003hbm.1_Silent_p.H834H	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	948	Pro-rich.									ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CTCCGGAGCACGACAAGGCAG	0.642													9	23					0	0	0	0	T	57182512	T	T	57182512	2	4	98	1	0	0	0	0	0	0	0	1	8254	535	19	1		1	KIAA1211	4	57182512	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	52012339	57182512	133971764	32	18763											
RASGEF1B	153020	broad.mit.edu	37	chr4	82369372	82369372	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccaggacttcttcgtactGgctgagcgcagcaagcttgc	7	10	12	12	2	1	1	0	1	1	0	2	2	1	2	1	2	6	5	1	2	2	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:82369372G>A	uc003hmi.1	-	5	649	c.505C>T	c.(505-507)CAG>TAG	p.Q169*	RASGEF1B_uc003hmj.1_Nonsense_Mutation_p.Q168*|RASGEF1B_uc010ijq.1_Nonsense_Mutation_p.Q127*	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	169					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						TCTTCGTACTGGCTGAGCGCA	0.463													76	105					0	0	0	0	A	82369372	A	A	82369372	4	1	98	1	0	0	0	0	0	1	0	0	13135	1357	47	4	956	4	RASGEF1B	4	82369372	Nonsense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	25186860	82369372	108784904	33	18764											
NDST4	64579	broad.mit.edu	37	chr4	115891710	115891710	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catccacagaccgaagtaaaAggtcatctccttcatcttcc	12	10	5	14	1	4	1	2	0	2	1	7	2	6	1	4	1	0	1	4	1	3	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:115891710A>T	uc003ibu.2	-	4	1776	c.1097T>A	c.(1096-1098)CTT>CAT	p.L366H	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	366	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CCGAAGTAAAAGGTCATCTCC	0.393													17	17					0	0	0	0	T	115891710	T	T	115891710	3	4	98	1	0	0	0	0	1	0	0	0	10312	72	3	5	1565	5	NDST4	4	115891710	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	33522338	115891710	75262566	34	18765											
FBXW7	55294	broad.mit.edu	37	chr4	153247244	153247244	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacacctttaccataaaatCatatgctccactaacaaccc	15	9	1	16	0	1	0	1	0	0	0	2	0	2	0	5	0	4	1	5	0	6	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:153247244C>G	uc003ims.2	-	10	1707	c.1558G>C	c.(1558-1560)GAT>CAT	p.D520H	FBXW7_uc011cii.1_Missense_Mutation_p.D520H|FBXW7_uc003imt.2_Missense_Mutation_p.D520H|FBXW7_uc011cih.1_Missense_Mutation_p.D344H|FBXW7_uc003imq.2_Missense_Mutation_p.D440H|FBXW7_uc003imr.2_Missense_Mutation_p.D402H	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	520	WD 4.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.D520N(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACCATAAAATCATATGCTCCA	0.433			Mis|N|D|F		colorectal|endometrial|T-ALL								102	35					0	0	0	0	G	153247244	G	G	153247244	3	3	98	1	0	0	0	0	1	0	0	0	5801	826	29	2	577	2	FBXW7	4	153247244	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	37355534	153247244	37907032	35	18766											
PLRG1	5356	broad.mit.edu	37	chr4	155459166	155459166	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttaccgtcaatgtgttaaTaatagcattatgaccggaaa	15	13	7	6	2	1	1	1	1	0	0	1	2	1	2	2	1	2	2	2	1	7	6			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:155459166T>C	uc003iny.2	-	13	1309	c.1246A>G	c.(1246-1248)ATT>GTT	p.I416V	PLRG1_uc003inz.2_Missense_Mutation_p.I407V	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	416	WD 6.					catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)				AATGTGTTAATAATAGCATTA	0.308													50	17					0	0	0	0	C	155459166	C	C	155459166	3	2	98	1	0	0	0	0	1	0	0	0	12161	1406	49	5	310	5	PLRG1	4	155459166	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	2211922	155459166	35695110	36	18767											
GRIA2	2891	broad.mit.edu	37	chr4	158254041	158254041	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcaacctaaggaagcaaaGaattgaaatctcccgaaggg	16	5	10	10	2	1	2	0	1	1	1	2	4	1	3	3	2	2	2	3	2	7	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr4:158254041G>T	uc003ipm.3	+	7	1412	c.953G>T	c.(952-954)AGA>ATA	p.R318I	GRIA2_uc011cit.1_Missense_Mutation_p.R271I|GRIA2_uc003ipl.3_Missense_Mutation_p.R318I|GRIA2_uc003ipk.3_Missense_Mutation_p.R271I|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	318	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AGGAAGCAAAGAATTGAAATC	0.483													26	39					9.78306e-22	1.11494e-21	1	0	T	158254041	T	T	158254041	3	4	98	1	0	0	0	0	1	0	0	0	6807	942	33	2	979	2	GRIA2	4	158254041	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	2794875	158254041	32900235	37	18768											
ADAMTS16	170690	broad.mit.edu	37	chr5	5319209	5319209	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgtgcagccacaagttctaCggcaagcagtgctgcaagac	12	7	11	11	1	1	1	0	0	1	1	1	1	1	1	1	1	6	6	1	1	4	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:5319209C>T	uc003jdl.2	+	23	3771	c.3633C>T	c.(3631-3633)TAC>TAT	p.Y1211Y		NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1211	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ACAAGTTCTACGGCAAGCAGT	0.522													7	7					0	0	0	0	T	5319209	T	T	5319209	2	4	98	1	0	0	0	0	0	0	0	1	261	547	19	1		1	ADAMTS16	5	5319209	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08		5319209	175596051	38	18769											
SEMA5A	9037	broad.mit.edu	37	chr5	9050539	9050539	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctccacaccttttctctTctacgctactggatcttgcc	6	15	4	16	1	3	0	0	0	3	0	5	1	4	1	4	1	4	1	4	1	3	7			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:9050539T>C	uc003jek.2	-	21	3588	c.2876A>G	c.(2875-2877)GAA>GGA	p.E959G		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	959	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CCTTTTCTCTTCTACGCTACT	0.363													14	31					0	0	0	0	C	9050539	C	C	9050539	3	2	98	1	0	0	0	0	1	0	0	0	14102	1783	62	5	360	5	SEMA5A	5	9050539	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	3731330	9050539	171864721	39	18770											
PDE4D	5144	broad.mit.edu	37	chr5	59284494	59284494	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaagatagggttccattccGcggaaagggtcttcctcttc	9	11	10	11	2	2	1	0	0	2	1	6	2	5	2	3	3	0	1	3	3	3	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:59284494G>A	uc003jsb.2	-	3	306	c.93C>T	c.(91-93)CGC>CGT	p.R31R	PDE4D_uc010iwj.1_Silent_p.R31R|PDE4D_uc003jse.1_Silent_p.R43R	NM_006203	NP_006194	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 2	Error:Variant_position_missing_in_Q08499_after_alignment					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GTTCCATTCCGCGGAAAGGGT	0.428													38	30					0	0	0	0	A	59284494	A	A	59284494	2	1	98	1	0	0	0	0	0	0	0	1	11696	1074	38	1		1	PDE4D	5	59284494	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	50233955	59284494	121630766	40	18771											
C5orf44	80006	broad.mit.edu	37	chr5	64946652	64946652	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagcttggtatgtgctgtGagttatacaactcaggctgg	8	14	12	7	0	2	1	2	1	0	0	2	1	2	1	0	3	4	5	0	3	4	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:64946652G>A	uc003jtz.3	+	6	774	c.444G>A	c.(442-444)GTG>GTA	p.V148V	C5orf44_uc003jua.3_Silent_p.V148V|C5orf44_uc003juc.3_Silent_p.V148V|C5orf44_uc010iwv.2_Silent_p.V148V	NM_024941	NP_079217	A5PLN9	CE044_HUMAN	hypothetical protein LOC80006 isoform 2	148										ovary(1)	1						TATGTGCTGTGAGTTATACAA	0.289													15	7					0	0	0	0	A	64946652	A	A	64946652	2	1	98	1	0	0	0	0	0	0	0	1	2313	1277	45	2		2	C5orf44	5	64946652	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	5662158	64946652	115968608	41	18772											
PCDHA2	56146	broad.mit.edu	37	chr5	140176805	140176805	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggagctggtcttactcgcaGcagaggcggcagagggtgtg	7	7	19	8	2	1	2	0	0	1	2	2	3	1	3	0	5	3	4	0	5	1	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:140176805G>T	uc003lhd.2	+	1	2362	c.2256G>T	c.(2254-2256)CAG>CAT	p.Q752H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.Q752H|PCDHA2_uc011czy.1_Missense_Mutation_p.Q752H	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	752	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTACTCGCAGCAGAGGCGGC	0.672													38	30					1.30998e-17	1.45237e-17	1	0	T	140176805	T	T	140176805	3	4	98	1	0	0	0	0	1	0	0	0	11578	962	34	4	2258	4	PCDHA2	5	140176805	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	75230153	140176805	40738455	42	18773											
KCNMB1	3779	broad.mit.edu	37	chr5	169805970	169805970	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtccacgctgcctgggatgTaggagcactgtggggagaaa	9	8	16	8	1	0	1	0	0	0	1	1	4	1	3	2	4	2	3	2	4	2	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:169805970T>A	uc003maq.1	-	4	714	c.314A>T	c.(313-315)TAC>TTC	p.Y105F	KCNIP1_uc003map.2_Intron	NM_004137	NP_004128	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated	105	Extracellular (Potential).				platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			ovary(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		GCCTGGGATGTAGGAGCACTG	0.478													18	17					0	0	0	0	A	169805970	A	A	169805970	3	1	98	1	0	0	0	0	1	0	0	0	8113	1638	57	5	265	5	KCNMB1	5	169805970	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	29629165	169805970	11109290	43	18774											
ZNF354A	6940	broad.mit.edu	37	chr5	178139206	178139206	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgatgagctttgtctaaaaGtttttccacatgtattacat	11	17	7	6	0	1	2	0	2	1	0	2	2	2	2	1	0	2	3	1	0	4	6			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr5:178139206G>C	uc003mjj.2	-	5	1871	c.1673C>G	c.(1672-1674)ACT>AGT	p.T558S		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	558	C2H2-type 12.				regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		TTGTCTAAAAGTTTTTCCACA	0.373													30	25					0	0	0	0	C	178139206	C	C	178139206	3	2	98	1	0	0	0	0	1	0	0	0	17931	1029	36	4	148	4	ZNF354A	5	178139206	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	8333236	178139206	2776054	44	18775											
DNAH8	1769	broad.mit.edu	37	chr6	38862507	38862507	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgccaactccttctaaatttCattacatcttcaatcttcga	11	16	2	12	1	5	0	2	0	3	0	7	1	6	0	2	0	3	0	2	0	5	6			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr6:38862507C>T	uc003ooe.1	+	57	8563	c.7963C>T	c.(7963-7965)CAT>TAT	p.H2655Y		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTCTAAATTTCATTACATCTT	0.363													19	10					0	0	0	0	T	38862507	T	T	38862507	3	4	98	1	0	0	0	0	1	0	0	0	4629	826	29	2	8181	2	DNAH8	6	38862507	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08		38862507	132252560	45	18776											
DNAH8	1769	broad.mit.edu	37	chr6	38890944	38890944	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acccagcaaagtaaagaattCaaagctcagattaataggtg	18	8	8	7	0	2	2	2	0	0	2	2	2	2	2	1	1	2	3	1	1	7	4	rs147574550	byFrequency	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr6:38890944C>G	uc003ooe.1	+	70	10722	c.10122C>G	c.(10120-10122)TTC>TTG	p.F3374L	uc003oof.1_RNA	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GTAAAGAATTCAAAGCTCAGA	0.443													3	29					0	0	0	0	G	38890944	G	G	38890944	3	3	98	1	0	0	0	0	1	0	0	0	4629	825	29	2	10392	2	DNAH8	6	38890944	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	28437	38890944	132224123	46	18777											
KLHL31	401265	broad.mit.edu	37	chr6	53519694	53519694	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctttccagtgtaggcatatGcaatgacagtggccaggcct	9	10	12	10	0	0	1	0	1	0	0	1	1	1	1	3	3	1	4	3	3	3	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr6:53519694G>A	uc003pcb.3	-	2	518	c.377C>T	c.(376-378)GCA>GTA	p.A126V		NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	126	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					GTAGGCATATGCAATGACAGT	0.413													56	229					0	0	0	0	A	53519694	A	A	53519694	3	1	98	1	0	0	0	0	1	0	0	0	8424	1319	46	4	1535	4	KLHL31	6	53519694	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	14628750	53519694	117595373	47	18778											
SLC35F1	222553	broad.mit.edu	37	chr6	118596680	118596680	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagccacactctatggtatTtctaacgtctgggaagaata	12	11	10	8	1	3	1	0	0	3	1	3	3	3	3	1	3	2	1	1	3	6	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr6:118596680T>G	uc003pxx.3	+	5	897	c.696T>G	c.(694-696)ATT>ATG	p.I232M	SLC35F1_uc003pxy.1_Missense_Mutation_p.I37M	NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	232	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		TCTATGGTATTTCTAACGTCT	0.443													25	44					0	0	0	0	G	118596680	G	G	118596680	3	3	98	1	0	0	0	0	1	0	0	0	14652	1829	64	5	714	5	SLC35F1	6	118596680	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	65076986	118596680	52518387	48	18779											
RADIL	55698	broad.mit.edu	37	chr7	4917507	4917507	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccttcaccagctcacgggcGctggaggtgccggtggccag	5	7	15	14	3	2	0	2	0	0	0	3	1	3	1	4	5	2	2	4	5	0	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:4917507G>A	uc003snj.1	-	2	437	c.264C>T	c.(262-264)AGC>AGT	p.S88S	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	88	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GCTCACGGGCGCTGGAGGTGC	0.672													7	53					0	0	0	0	A	4917507	A	A	4917507	2	1	98	1	0	0	0	0	0	0	0	1	13062	1078	38	1		1	RADIL	7	4917507	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08		4917507	154221156	49	18780											
EPDR1	54749	broad.mit.edu	37	chr7	37988563	37988563	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttgacattcctcaaaacTccacctttgaagaccagtac	12	11	4	14	0	2	3	1	2	1	1	4	3	4	3	4	0	2	1	4	0	4	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:37988563T>A	uc003tfp.2	+	2	770	c.751T>A	c.(751-753)TCC>ACC	p.S251T	EPDR1_uc003tfq.2_Intron|EPDR1_uc010kxh.2_Missense_Mutation_p.S70T	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	131					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						TCCTCAAAACTCCACCTTTGA	0.512													7	82					0	0	0	0	A	37988563	A	A	37988563	3	1	98	1	0	0	0	0	1	0	0	0	5187	1551	54	5	757	5	EPDR1	7	37988563	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	33071056	37988563	121150100	50	18781											
TNS3	64759	broad.mit.edu	37	chr7	47342762	47342762	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccctgcaggcctggactGtggtggctgctgtgtccagg	3	10	17	11	0	0	0	0	0	0	0	1	1	1	1	3	6	2	3	3	6	0	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:47342762G>A	uc003tnv.2	-	22	3610	c.3243C>T	c.(3241-3243)CAC>CAT	p.H1081H	TNS3_uc003tnw.2_Silent_p.H1081H	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	1081						focal adhesion	protein binding			ovary(4)	4						GGCCTGGACTGTGGTGGCTGC	0.667													7	32					0	0	0	0	A	47342762	A	A	47342762	2	1	98	1	0	0	0	0	0	0	0	1	16410	1368	48	4		4	TNS3	7	47342762	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	9354199	47342762	111795901	51	18782											
ABHD11	83451	broad.mit.edu	37	chr7	73152999	73152999	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctcggcgccccctcggccGccgctgctgctgctgggtgc	0	7	16	18	5	0	0	0	0	0	0	2	0	0	0	4	4	4	5	4	4	0	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:73152999G>A	uc003tzb.2	-	1	186	c.129C>T	c.(127-129)GGC>GGT	p.G43G	RFC2_uc011kfa.1_Intron|ABHD11_uc011kfb.1_Silent_p.G43G|ABHD11_uc003tzc.2_Silent_p.G43G|ABHD11_uc003tza.2_5'UTR|ABHD11_uc003tzf.2_Silent_p.G43G|ABHD11_uc011kfc.1_Silent_p.G43G	NM_148912	NP_683710	Q8NFV4	ABHDB_HUMAN	abhydrolase domain containing 11 isoform 1	43							hydrolase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CCCCTCGGCCGCCGCTGCTGC	0.741													4	4					0	0	0	0	A	73152999	A	A	73152999	2	1	98	1	0	0	0	0	0	0	0	1	75	1074	38	1		1	ABHD11	7	73152999	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	25810237	73152999	85985664	52	18783											
PION	54103	broad.mit.edu	37	chr7	76984631	76984631	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttctgcagaagctgtaataAagacgactggctgagcagtg	12	9	13	7	1	1	3	0	1	1	2	1	4	1	3	0	1	3	6	0	1	4	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:76984631A>T	uc003ugf.2	-	16	1316	c.1237T>A	c.(1237-1239)TTA>ATA	p.L413I	PION_uc003ugg.1_Missense_Mutation_p.L198I	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	413					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						AGCTGTAATAAAGACGACTGG	0.502													34	74					0	0	0	0	T	76984631	T	T	76984631	3	4	98	1	0	0	0	0	1	0	0	0	11989	11	1	5	1391	5	PION	7	76984631	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	3831632	76984631	82154032	53	18784											
PCLO	27445	broad.mit.edu	37	chr7	82581457	82581457	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaccacatcacagcacacagCtcttctccctgcggttaaat	12	9	5	15	1	3	0	1	0	2	0	4	0	3	0	2	1	4	3	2	1	3	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:82581457C>G	uc003uhx.2	-	5	9101	c.8812G>C	c.(8812-8814)GCT>CCT	p.A2938P	PCLO_uc003uhv.2_Missense_Mutation_p.A2938P|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2869					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CAGCACACAGCTCTTCTCCCT	0.433													8	91					0	0	0	0	G	82581457	G	G	82581457	3	3	98	1	0	0	0	0	1	0	0	0	11637	797	28	4	6717	4	PCLO	7	82581457	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	5596826	82581457	76557206	54	18785											
ZNF804B	219578	broad.mit.edu	37	chr7	88963672	88963672	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caccactcttcaatggcctaCggaacttctgctctttacaa	10	12	5	14	1	4	0	1	0	3	0	4	1	4	1	2	2	4	1	2	2	5	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:88963672C>T	uc011khi.1	+	4	1914	c.1376C>T	c.(1375-1377)ACG>ATG	p.T459M		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	459						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CAATGGCCTACGGAACTTCTG	0.428										HNSCC(36;0.09)			23	52					0	0	0	0	T	88963672	T	T	88963672	3	4	98	1	0	0	0	0	1	0	0	0	18238	536	19	1	1390	1	ZNF804B	7	88963672	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	6382215	88963672	70174991	55	18786											
CUX1	1523	broad.mit.edu	37	chr7	101740740	101740740	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaaacttagggaaactcTggaagaatacaacaaggaat	19	6	9	7	0	1	2	0	0	1	2	1	5	1	5	1	3	4	0	1	3	9	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:101740740T>G	uc003uyx.3	+	5	403	c.365T>G	c.(364-366)CTG>CGG	p.L122R	CUX1_uc003uys.3_Missense_Mutation_p.L133R|CUX1_uc003uyt.2_Missense_Mutation_p.L133R|CUX1_uc011kkn.1_Missense_Mutation_p.L96R|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Missense_Mutation_p.L117R|CUX1_uc003uyu.2_Missense_Mutation_p.L133R	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	122	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						AGGGAAACTCTGGAAGAATAC	0.378													6	64					0	0	0	0	G	101740740	G	G	101740740	3	3	98	1	0	0	0	0	1	0	0	0	4081	1580	55	5	450	5	CUX1	7	101740740	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	12777068	101740740	57397923	56	18787											
C7orf58	79974	broad.mit.edu	37	chr7	120737809	120737809	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atcagggaatgcaattaaagCcgagtacttcgagtcacctt	13	10	9	9	2	2	0	2	0	0	0	3	3	2	1	2	1	3	2	2	1	5	4	rs144805034	byFrequency	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:120737809C>T	uc003vjq.3	+	6	1120	c.673C>T	c.(673-675)CCG>TCG	p.P225S	C7orf58_uc003vjr.1_Missense_Mutation_p.P225S|C7orf58_uc003vjs.3_Missense_Mutation_p.P225S|C7orf58_uc003vjt.3_Missense_Mutation_p.P5S|C7orf58_uc010lkk.1_Missense_Mutation_p.P5S	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	225						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					GCAATTAAAGCCGAGTACTTC	0.428													6	109					0	0	0	0	T	120737809	T	T	120737809	3	4	98	1	0	0	0	0	1	0	0	0	2416	739	26	4	691	4	C7orf58	7	120737809	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	18997069	120737809	38400854	57	18788											
LMOD2	442721	broad.mit.edu	37	chr7	123302785	123302785	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taggaccaaagtctggcaaaGaggaacacctagctcttcac	14	7	9	11	0	3	1	1	0	2	1	3	3	3	3	2	3	2	2	2	3	5	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:123302785G>C	uc003vky.2	+	2	1302	c.1145G>C	c.(1144-1146)AGA>ACA	p.R382T		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	382						cytoskeleton	actin binding|tropomyosin binding				0						GTCTGGCAAAGAGGAACACCT	0.488													32	47					0	0	0	0	C	123302785	C	C	123302785	3	2	98	1	0	0	0	0	1	0	0	0	8899	942	33	2	1151	2	LMOD2	7	123302785	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	2564976	123302785	35835878	58	18789											
PARP12	64761	broad.mit.edu	37	chr7	139741483	139741483	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caagaaccaaactcatcactCcagtaccaaatccagtcagt	16	7	4	14	0	3	1	3	0	0	1	5	1	5	1	4	0	3	1	4	0	5	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:139741483C>A	uc003vvl.1	-	6	2017	c.1143G>T	c.(1141-1143)TGG>TGT	p.W381C	PARP12_uc003vvk.1_Missense_Mutation_p.W167C|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	381	WWE 2.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					ACTCATCACTCCAGTACCAAA	0.512													74	125					1.36236e-49	1.5791e-49	1	0	A	139741483	A	A	139741483	3	1	98	1	0	0	0	0	1	0	0	0	11511	856	30	2	990	2	PARP12	7	139741483	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	16438698	139741483	19397180	59	18790											
WEE2	494551	broad.mit.edu	37	chr7	141408764	141408764	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtgcatgagctcgacacatCttcggaaaaagacaaagaaa	17	6	9	9	3	1	3	0	1	1	2	3	5	1	4	0	1	2	2	0	1	4	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:141408764C>T	uc003vwn.2	+	1	612	c.206C>T	c.(205-207)TCT>TTT	p.S69F	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	69					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					CTCGACACATCTTCGGAAAAA	0.522													15	191					0	0	0	0	T	141408764	T	T	141408764	3	4	98	1	0	0	0	0	1	0	0	0	17413	913	32	2	208	2	WEE2	7	141408764	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	1667281	141408764	17729899	60	18791											
PRSS37	136242	broad.mit.edu	37	chr7	141537030	141537030	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggggcctccaggttctgcCgcaagtcagggtgtcggcct	4	8	16	13	3	2	0	1	0	1	0	4	0	3	0	4	5	1	2	4	5	1	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr7:141537030C>T	uc003vws.1	-	4	821	c.449G>A	c.(448-450)CGG>CAG	p.R150Q	PRSS37_uc011krk.1_Missense_Mutation_p.R137Q|PRSS37_uc011krl.1_Missense_Mutation_p.R149Q|PRSS37_uc003vwt.1_Missense_Mutation_p.R137Q	NM_001008270	NP_001008271	A4D1T9	PRS37_HUMAN	protease, serine, 37 precursor	150	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			skin(1)	1						CAGGTTCTGCCGCAAGTCAGG	0.458													24	60					0	0	0	0	T	141537030	T	T	141537030	3	4	98	1	0	0	0	0	1	0	0	0	12688	652	23	1	266	1	PRSS37	7	141537030	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	128266	141537030	17601633	61	18792											
IMPA1	3612	broad.mit.edu	37	chr8	82572902	82572902	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gctgttccaacactccggatCctaacaaatagaatttagaa	15	10	6	10	1	0	2	0	0	0	2	3	3	3	3	3	1	2	2	3	1	7	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr8:82572902C>G	uc003ych.2	-	8	694	c.567G>C	c.(565-567)GGG>GGC	p.G189G	IMPA1_uc011lfq.1_Silent_p.G248G|IMPA1_uc011lfr.1_Missense_Mutation_p.G153A	NM_005536	NP_005527	P29218	IMPA1_HUMAN	inositol(myo)-1(or 4)-monophosphatase 1 isoform	189					inositol phosphate dephosphorylation|phosphatidylinositol biosynthetic process|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(1)	1					Lithium(DB01356)	CACTCCGGATCCTAACAAATA	0.378													10	35					0	0	0	0	G	82572902	G	G	82572902	2	3	98	1	0	0	0	0	0	0	0	1	7761	869	30	2		2	IMPA1	8	82572902	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08		82572902	63791120	62	18793											
CNBD1	168975	broad.mit.edu	37	chr8	87951834	87951834	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttgttcagggaactcaatGaaggcaaagaggaaagtcaa	16	8	11	6	0	4	2	3	1	1	1	4	4	4	4	0	3	1	2	0	3	6	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr8:87951834G>A	uc003ydy.2	+	4	331	c.283G>A	c.(283-285)GAA>AAA	p.E95K		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	95										ovary(3)	3						GGAACTCAATGAAGGCAAAGA	0.338													12	62					0	0	0	0	A	87951834	A	A	87951834	3	1	98	1	0	0	0	0	1	0	0	0	3606	1291	45	2	297	2	CNBD1	8	87951834	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	5378932	87951834	58412188	63	18794											
FAM49B	51571	broad.mit.edu	37	chr8	130854420	130854420	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggatttaatttgcttggaggTagtctcatcattcaaatgtt	10	17	9	5	0	3	0	3	0	1	0	4	2	3	2	0	3	1	3	0	3	3	7			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr8:130854420T>C	uc003yss.2	-	15	1492	c.943A>G	c.(943-945)ACC>GCC	p.T315A	FAM49B_uc003yst.2_Missense_Mutation_p.T315A|FAM49B_uc003ysu.2_Missense_Mutation_p.T315A|FAM49B_uc003ysv.2_Missense_Mutation_p.T169A|FAM49B_uc003ysw.2_Missense_Mutation_p.T315A|FAM49B_uc003ysx.2_Missense_Mutation_p.T315A	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	hypothetical protein LOC51571	315											0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TGCTTGGAGGTAGTCTCATCA	0.328													5	47					0	0	0	0	C	130854420	C	C	130854420	3	2	98	1	0	0	0	0	1	0	0	0	5608	1638	57	5	35	5	FAM49B	8	130854420	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	42902586	130854420	15509602	64	18795											
ADCY8	114	broad.mit.edu	37	chr8	131964216	131964216	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatttccaggacaacaaacCgggggagcacagaaagcacg	15	4	11	11	2	1	1	1	0	0	1	2	3	2	3	2	3	4	2	2	3	3	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr8:131964216C>T	uc003ytd.3	-	3	1395	c.1139G>A	c.(1138-1140)CGG>CAG	p.R380Q	ADCY8_uc010mds.2_Missense_Mutation_p.R380Q	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	380	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GACAACAAACCGGGGGAGCAC	0.547										HNSCC(32;0.087)			21	21					0	0	0	0	T	131964216	T	T	131964216	3	4	98	1	0	0	0	0	1	0	0	0	300	652	23	1	2680	1	ADCY8	8	131964216	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	1109796	131964216	14399806	65	18796											
COL22A1	169044	broad.mit.edu	37	chr8	139706770	139706770	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggtggtccagtgggtcccTgaggccccaattctccagga	6	8	13	14	1	1	1	0	1	1	0	4	2	3	2	6	5	0	0	6	5	1	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr8:139706770T>A	uc003yvd.2	-	34	3128	c.2681A>T	c.(2680-2682)CAG>CTG	p.Q894L	COL22A1_uc011ljo.1_Missense_Mutation_p.Q194L	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	894	Pro-rich.|Gly-rich.|Collagen-like 7.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AGTGGGTCCCTGAGGCCCCAA	0.612										HNSCC(7;0.00092)			58	59					0	0	0	0	A	139706770	A	A	139706770	3	1	98	1	0	0	0	0	1	0	0	0	3696	1580	55	5	2327	5	COL22A1	8	139706770	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	7742554	139706770	6657252	66	18797											
UHRF2	115426	broad.mit.edu	37	chr9	6460622	6460622	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtcaaggatcttagaccaCgagctagaaccattttgaaa	15	10	8	8	1	2	3	1	1	1	2	2	5	2	4	2	1	2	1	2	1	5	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:6460622C>T	uc003zjy.2	+	4	1034	c.694C>T	c.(694-696)CGA>TGA	p.R232*	UHRF2_uc003zjz.2_RNA|UHRF2_uc003zka.1_Nonsense_Mutation_p.R9*	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains	232	Interaction with PCNP.				cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		TCTTAGACCACGAGCTAGAAC	0.373													30	34					0	0	0	0	T	6460622	T	T	6460622	4	4	98	1	0	0	0	0	0	1	0	0	17038	528	19	1	708	1	UHRF2	9	6460622	Nonsense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08		6460622	134752809	67	18798											
PRKACG	5568	broad.mit.edu	37	chr9	71628058	71628058	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccccagggcctgtgtacttCgggatgaagggagcttccac	7	9	13	12	1	0	1	0	1	0	0	3	3	2	3	4	3	2	2	4	3	2	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:71628058C>T	uc004agy.2	-	1	982	c.951G>A	c.(949-951)CCG>CCA	p.P317P		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	317	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						CTGTGTACTTCGGGATGAAGG	0.532													40	11					0	0	0	0	T	71628058	T	T	71628058	2	4	98	1	0	0	0	0	0	0	0	1	12561	871	31	1		1	PRKACG	9	71628058	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	65167436	71628058	69585373	68	18799											
TLE1	7088	broad.mit.edu	37	chr9	84202720	84202720	+	Frame_Shift_Del	DEL	C	-	-																															aaatgtcaatacagctggctCcgtctgtgtggccctggaat																										TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:84202720delC	uc004aly.2	-	17	2294	c.1853delG	c.(1852-1854)GGAfs	p.G618fs	TLE1_uc004alz.2_Frame_Shift_Del_p.G628fs|TLE1_uc011lsr.1_Frame_Shift_Del_p.G603fs	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	618	WD 4.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						ACAGCTGGCTCCGTCTGTGTG	0.502													---	---	---								-	84202720	-	-	84202720	7	5	98	1	0	1	0	1	0	0	0	0	16004	855	30	0	475	0	TLE1	9	84202720	Frame_Shift_Del	DEL	C	TCGA-CQ-5332-01A-01D-1683-08	12574662	84202720	57010711	69	18800											
PAPPA	5069	broad.mit.edu	37	chr9	118973944	118973944	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgtcttgaacccatctttcTatggcatgcctgggcacacc	7	13	8	13	0	3	1	0	1	3	0	3	1	3	1	3	2	2	2	3	2	2	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:118973944T>C	uc004bjn.2	+	4	2032	c.1651T>C	c.(1651-1653)TAT>CAT	p.Y551H	PAPPA_uc011lxp.1_Intron|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	551	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CCCATCTTTCTATGGCATGCC	0.517													26	49					0	0	0	0	C	118973944	C	C	118973944	3	2	98	1	0	0	0	0	1	0	0	0	11486	1522	53	5	1665	5	PAPPA	9	118973944	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	34771224	118973944	22239487	70	18801											
FPGS	2356	broad.mit.edu	37	chr9	130566689	130566689	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacctggcacggagtgggctGcaggtaaggtagagagggcc	9	6	18	8	1	0	1	0	0	0	1	0	3	0	2	2	6	2	5	2	6	3	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:130566689G>T	uc004bsg.1	+	2	314	c.264G>T	c.(262-264)CTG>CTT	p.L88L	FPGS_uc004bsf.1_RNA|FPGS_uc004bsh.1_5'UTR|FPGS_uc011mal.1_Silent_p.L88L|FPGS_uc004bsi.1_Silent_p.L38L	NM_004957	NP_004948	Q05932	FOLC_HUMAN	folylpolyglutamate synthase isoform a precursor	88					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity				0					L-Glutamic Acid(DB00142)	GGAGTGGGCTGCAGGTAAGGT	0.607													22	32					1.36565e-18	1.52236e-18	1	0	T	130566689	T	T	130566689	2	4	98	1	0	0	0	0	0	0	0	1	6070	1306	46	4		4	FPGS	9	130566689	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	11592745	130566689	10646742	71	18802											
WDR34	89891	broad.mit.edu	37	chr9	131396039	131396039	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccctcaggccgccacctctGctgccaggcagtccaggtcc	5	6	10	20	1	2	0	1	0	1	0	4	0	4	0	8	3	2	2	8	3	0	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr9:131396039G>T	uc004bvq.1	-	9	1719	c.1595C>A	c.(1594-1596)GCA>GAA	p.A532E	WDR34_uc004bvs.1_Missense_Mutation_p.A523E|WDR34_uc004bvr.1_Missense_Mutation_p.A504E	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	532						cytoplasm				central_nervous_system(2)|skin(1)	3						CGCCACCTCTGCTGCCAGGCA	0.627													122	166					1.61494e-73	1.89337e-73	1	0	T	131396039	T	T	131396039	3	4	98	1	0	0	0	0	1	0	0	0	17356	1319	46	4	19	4	WDR34	9	131396039	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	829350	131396039	9817392	72	18803											
MLLT10	8028	broad.mit.edu	37	chr10	21823717	21823717	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcgacgggcacggctgcagCgtcgcggtgcatcaaggtaa	8	6	16	11	6	1	0	1	0	0	0	2	1	1	0	0	4	4	5	0	4	2	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr10:21823717C>G	uc001iqs.2	+	2	492	c.144C>G	c.(142-144)AGC>AGG	p.S48R	MLLT10_uc001iqt.2_Missense_Mutation_p.S48R|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.S48R|MLLT10_uc001iqr.1_Missense_Mutation_p.S48R|MLLT10_uc001iqq.1_Missense_Mutation_p.S48R|MLLT10_uc001iqu.1_Missense_Mutation_p.S48R|MLLT10_uc009xke.1_RNA|MLLT10_uc001iqw.1_Missense_Mutation_p.S48R|MLLT10_uc001iqx.1_RNA|MLLT10_uc009xkf.1_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	48	PHD-type 1.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						ACGGCTGCAGCGTCGCGGTGC	0.408			T	MLL|PICALM|CDK6	AL								4	37					0	0	0	0	G	21823717	G	G	21823717	3	3	98	1	0	0	0	0	1	0	0	0	9679	767	27	3	146	3	MLLT10	10	21823717	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08		21823717	113711030	73	18804											
ITGB1	3688	broad.mit.edu	37	chr10	33217097	33217097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actttttacattctccaaatCgtctttcattgagtaagaca	12	16	4	9	1	3	2	1	1	2	1	5	2	3	2	1	0	1	1	1	0	3	7			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr10:33217097C>T	uc001iws.3	-	5	608	c.472G>A	c.(472-474)GAT>AAT	p.D158N	ITGB1_uc001iwp.3_Missense_Mutation_p.D158N|ITGB1_uc001iwq.3_Missense_Mutation_p.D158N|ITGB1_uc001iwr.3_Missense_Mutation_p.D158N|ITGB1_uc001iwt.3_Missense_Mutation_p.D158N|ITGB1_uc001iwu.1_Missense_Mutation_p.D158N	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	158	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TTCTCCAAATCGTCTTTCATT	0.373													52	87					0	0	0	0	T	33217097	T	T	33217097	3	4	98	1	0	0	0	0	1	0	0	0	7929	884	31	1	2210	1	ITGB1	10	33217097	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	11393380	33217097	102317650	74	18805											
NOC3L	64318	broad.mit.edu	37	chr10	96097619	96097620	+	Frame_Shift_Ins	INS	-	A	A																															gcaaatctctgcactatgggINSatgataatgcctctgaaggg																										TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr10:96097619_96097620insA	uc001kjq.1	-	19	2191_2192	c.2103_2104insT	c.(2101-2106)CATCCCfs	p.H701fs		NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	701_702						nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				TGCACTATGGGATGATAATGCC	0.431													---	---	---								A	96097620	A	A	96097619	7	5	98	1	0	1	1	0	0	0	0	0	10568	1174	41	0	310	0	NOC3L	10	96097619	Frame_Shift_Ins	INS	-	TCGA-CQ-5332-01A-01D-1683-08	62880522	96097619	39437128	75	18806											
NRAP	4892	broad.mit.edu	37	chr10	115393949	115393949	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagctgtacttcaacttgtcGatgctctgcctataattggc	8	14	9	10	1	2	0	1	0	1	0	3	2	2	0	1	1	5	3	1	1	4	6	rs141308047		TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr10:115393949G>A	uc001laj.2	-	15	1613	c.1449C>T	c.(1447-1449)ATC>ATT	p.I483I	NRAP_uc001lak.2_Silent_p.I448I|NRAP_uc001lal.3_Silent_p.I483I	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	483						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TCAACTTGTCGATGCTCTGCC	0.458													34	43					0	0	0	0	A	115393949	A	A	115393949	2	1	98	1	0	0	0	0	0	0	0	1	10692	1048	37	1		1	NRAP	10	115393949	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	19296330	115393949	20140798	76	18807											
C10orf137	26098	broad.mit.edu	37	chr10	127438083	127438083	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaaagatgctccctgcgaaCtgcttagagtacagctagag	12	9	11	9	1	0	4	0	1	0	3	1	5	1	4	1	0	6	4	1	0	5	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr10:127438083C>T	uc001liq.1	+	22	3519	c.3226C>T	c.(3226-3228)CTG>TTG	p.L1076L	C10orf137_uc001lio.1_Silent_p.L1042L|C10orf137_uc001lip.1_Silent_p.L780L|C10orf137_uc001lis.1_Silent_p.L402L|C10orf137_uc001lit.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	1076					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TCCCTGCGAACTGCTTAGAGT	0.443													27	22					0	0	0	0	T	127438083	T	T	127438083	2	4	98	1	0	0	0	0	0	0	0	1	1600	564	20	4		4	C10orf137	10	127438083	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	12044134	127438083	8096664	77	18808											
RAG2	5897	broad.mit.edu	37	chr11	36614176	36614176	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggatttcttggcaggagTcaagatttttccagaacctt	12	13	9	7	0	2	2	1	0	1	2	3	4	3	4	2	3	1	1	2	3	3	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:36614176T>G	uc001mwv.3	-	2	1731	c.1543A>C	c.(1543-1545)ACT>CCT	p.T515P	RAG1_uc001mwt.2_Intron|C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	515					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TTGGCAGGAGTCAAGATTTTT	0.373									Familial_Hemophagocytic_Lymphohistiocytosis				17	15					0	0	0	0	G	36614176	G	G	36614176	3	3	98	1	0	0	0	0	1	0	0	0	13070	1667	58	5	44	5	RAG2	11	36614176	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08		36614176	98392340	78	18809											
OR5L2	26338	broad.mit.edu	37	chr11	55594934	55594934	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcaataattgtgccaaaGatgttggctaatatctttaa	13	15	6	7	0	2	1	1	0	1	1	3	1	3	1	2	1	1	2	2	1	6	7			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:55594934G>T	uc001nhy.1	+	1	240	c.240G>T	c.(238-240)AAG>AAT	p.K80N		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TTGTGCCAAAGATGTTGGCTA	0.463										HNSCC(27;0.073)			51	110					6.08268e-21	6.8937e-21	1	0	T	55594934	T	T	55594934	3	4	98	1	0	0	0	0	1	0	0	0	11225	933	33	2	242	2	OR5L2	11	55594934	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	18980758	55594934	79411582	79	18810											
OR5AR1	219493	broad.mit.edu	37	chr11	56431630	56431630	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggctggtctagtgagtttaGtagcccacactaccctcacc	8	11	9	13	0	2	1	1	1	1	0	2	1	2	1	3	2	2	3	3	2	4	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:56431630G>T	uc010rjm.1	+	1	469	c.469G>T	c.(469-471)GTA>TTA	p.V157L		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGTGAGTTTAGTAGCCCACAC	0.512													65	74					5.82089e-37	6.70882e-37	1	0	T	56431630	T	T	56431630	3	4	98	1	0	0	0	0	1	0	0	0	11199	1029	36	4	471	4	OR5AR1	11	56431630	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	836696	56431630	78574886	80	18811											
INPPL1	3636	broad.mit.edu	37	chr11	71942214	71942214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgggggcctcaaggagcttaCggatctggattaccgcccgg	7	7	15	12	4	2	0	1	0	1	0	2	3	2	3	3	6	3	1	3	6	3	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:71942214C>T	uc001osf.2	+	12	1625	c.1478C>T	c.(1477-1479)ACG>ATG	p.T493M	INPPL1_uc001osg.2_Missense_Mutation_p.T251M	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	493					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						AAGGAGCTTACGGATCTGGAT	0.592													12	196					0	0	0	0	T	71942214	T	T	71942214	3	4	98	1	0	0	0	0	1	0	0	0	7800	536	19	1	1524	1	INPPL1	11	71942214	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	15510584	71942214	63064302	81	18812											
GRIK4	2900	broad.mit.edu	37	chr11	120776051	120776051	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggagatggaaggcaatgAccgctacgagggcttctgtg	10	7	15	9	2	1	2	0	1	1	1	1	5	1	3	2	4	1	3	2	4	3	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:120776051A>G	uc001pxn.2	+	13	1612	c.1325A>G	c.(1324-1326)GAC>GGC	p.D442G	GRIK4_uc009zav.1_Missense_Mutation_p.D442G|GRIK4_uc009zaw.1_Missense_Mutation_p.D442G|GRIK4_uc009zax.1_Missense_Mutation_p.D442G	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	442	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GAAGGCAATGACCGCTACGAG	0.537													62	93					0	0	0	0	G	120776051	G	G	120776051	3	3	98	1	0	0	0	0	1	0	0	0	6815	275	10	5	1367	5	GRIK4	11	120776051	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	48833837	120776051	14230465	82	18813											
TECTA	7007	broad.mit.edu	37	chr11	121008284	121008284	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcagccagtgtgtcacGcggagtgagtgtggctgcaa	7	8	17	9	2	1	1	1	1	0	0	1	2	1	2	1	3	2	3	1	3	1	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:121008284G>A	uc010rzo.1	+	10	3096	c.3096G>A	c.(3094-3096)ACG>ACA	p.T1032T		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1032	TIL 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGTGTGTCACGCGGAGTGAGT	0.577													30	24					0	0	0	0	A	121008284	A	A	121008284	2	1	98	1	0	0	0	0	0	0	0	1	15813	1074	38	1		1	TECTA	11	121008284	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	232233	121008284	13998232	83	18814											
OR8B8	26493	broad.mit.edu	37	chr11	124310617	124310617	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggttacagatggccacatagCggtcatacgccattgctgac	10	9	11	11	2	1	2	1	1	0	1	1	2	1	2	2	3	4	2	2	3	3	4	rs144609364	byFrequency	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:124310617C>T	uc010sal.1	-	1	365	c.365G>A	c.(364-366)CGC>CAC	p.R122H		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GGCCACATAGCGGTCATACGC	0.488													6	24					0	0	0	0	T	124310617	T	T	124310617	3	4	98	1	0	0	0	0	1	0	0	0	11284	768	27	1	573	1	OR8B8	11	124310617	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	3302333	124310617	10695899	84	18815											
KCNJ1	3758	broad.mit.edu	37	chr11	128709340	128709340	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaagtcctgctggagaaGggtctccgctgccatgtgga	8	10	13	10	1	2	1	1	0	1	1	4	3	3	2	3	3	2	2	3	3	2	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr11:128709340G>A	uc001qeo.1	-	2	907	c.856C>T	c.(856-858)CTT>TTT	p.L286F	KCNJ1_uc001qep.1_Missense_Mutation_p.L267F|KCNJ1_uc001qeq.1_Missense_Mutation_p.L267F|KCNJ1_uc001qer.1_Missense_Mutation_p.L267F|KCNJ1_uc001qes.1_Missense_Mutation_p.L267F	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	286	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	TGCTGGAGAAGGGTCTCCGCT	0.478													14	40					0	0	0	0	A	128709340	A	A	128709340	3	1	98	1	0	0	0	0	1	0	0	0	8082	1000	35	4	323	4	KCNJ1	11	128709340	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	4398723	128709340	6297176	85	18816											
AKAP3	10566	broad.mit.edu	37	chr12	4737262	4737262	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catcaggcctttcctgccctCgaaacctctttctctcccga	6	12	5	18	2	3	0	1	0	2	0	7	2	5	0	5	1	2	0	5	1	1	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:4737262C>T	uc001qnb.3	-	4	1035	c.806G>A	c.(805-807)CGA>CAA	p.R269Q		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	269					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						TTCCTGCCCTCGAAACCTCTT	0.443													50	43					0	0	0	0	T	4737262	T	T	4737262	3	4	98	1	0	0	0	0	1	0	0	0	452	884	31	1	1763	1	AKAP3	12	4737262	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08		4737262	129114633	86	18817											
GALNT8	26290	broad.mit.edu	37	chr12	4835920	4835920	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcggcccaggacctcttccGgaagtttggttacaacgcgt	7	9	13	12	4	1	0	0	0	1	0	2	2	2	2	3	5	2	2	3	5	3	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:4835920G>A	uc001qne.1	+	2	526	c.434G>A	c.(433-435)CGG>CAG	p.R145Q		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	145	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						GACCTCTTCCGGAAGTTTGGT	0.562													16	50					0	0	0	0	A	4835920	A	A	4835920	3	1	98	1	0	0	0	0	1	0	0	0	6254	1116	39	1	440	1	GALNT8	12	4835920	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	98658	4835920	129015975	87	18818											
MANSC1	54682	broad.mit.edu	37	chr12	12483418	12483418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactgtagaaatgagggtcGtgggaggctgagaagtgaca	14	7	16	4	1	0	4	0	3	0	2	1	6	0	5	0	3	1	2	0	3	4	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:12483418G>A	uc001rai.1	-	4	1097	c.839C>T	c.(838-840)ACG>ATG	p.T280M	MANSC1_uc010shm.1_Missense_Mutation_p.T214M|MANSC1_uc001raj.1_Missense_Mutation_p.T246M|MANSC1_uc009zht.1_Missense_Mutation_p.T199M	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	280	Thr-rich.|Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		AATGAGGGTCGTGGGAGGCTG	0.547													31	31					0	0	0	0	A	12483418	A	A	12483418	3	1	98	1	0	0	0	0	1	0	0	0	9277	1145	40	1	460	1	MANSC1	12	12483418	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	7647498	12483418	121368477	88	18819											
SLCO1B3	28234	broad.mit.edu	37	chr12	21028240	21028240	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtttccttgtgtctggaCtattttccattatttcttcc	4	22	6	9	0	2	0	0	0	2	0	5	1	5	1	3	2	0	1	3	2	2	9			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:21028240C>A	uc001rek.2	+	8	925	c.799C>A	c.(799-801)CTA>ATA	p.L267I	SLCO1B3_uc001rel.2_Missense_Mutation_p.L267I|SLCO1B3_uc010sil.1_Missense_Mutation_p.L267I|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.L92I	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	267	Helical; Name=6; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TGTGTCTGGACTATTTTCCAT	0.378													24	191					2.39556e-15	2.62739e-15	1	0	A	21028240	A	A	21028240	3	1	98	1	0	0	0	0	1	0	0	0	14788	564	20	4	825	4	SLCO1B3	12	21028240	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	8544822	21028240	112823655	89	18820											
CAPRIN2	65981	broad.mit.edu	37	chr12	30881780	30881780	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacacatgggagtggtccaTgacttggtggtgttctgttc	6	14	13	8	0	2	1	1	1	1	0	4	2	3	2	1	4	0	2	1	4	0	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:30881780T>C	uc001rji.1	-	8	2335	c.1584A>G	c.(1582-1584)TCA>TCG	p.S528S	CAPRIN2_uc001rjf.1_Silent_p.S325S|CAPRIN2_uc001rjg.1_Silent_p.S195S|CAPRIN2_uc001rjh.1_Silent_p.S528S|CAPRIN2_uc001rjj.1_Silent_p.S195S|CAPRIN2_uc001rjk.3_Silent_p.S528S|CAPRIN2_uc001rjl.3_Silent_p.S528S|CAPRIN2_uc001rjm.1_Silent_p.S195S|CAPRIN2_uc001rjn.1_Silent_p.S195S	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	528					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GAGTGGTCCATGACTTGGTGG	0.453													84	236					0	0	0	0	C	30881780	C	C	30881780	2	2	98	1	0	0	0	0	0	0	0	1	2648	1451	51	5		5	CAPRIN2	12	30881780	Silent	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	9853540	30881780	102970115	90	18821											
LRRK2	120892	broad.mit.edu	37	chr12	40681307	40681307	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgactcttctatggacagTgtgtttgctcaaagtgatga	9	14	10	8	0	3	3	1	3	2	0	3	4	3	4	1	1	1	2	1	1	2	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:40681307T>C	uc001rmg.3	+	20	2776	c.2655T>C	c.(2653-2655)AGT>AGC	p.S885S	LRRK2_uc001rmh.1_Silent_p.S507S	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	885					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTATGGACAGTGTGTTTGCTC	0.373													6	36					0	0	0	0	C	40681307	C	C	40681307	2	2	98	1	0	0	0	0	0	0	0	1	9083	1693	59	5		5	LRRK2	12	40681307	Silent	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	9799527	40681307	93170588	91	18822											
KRT81	3887	broad.mit.edu	37	chr12	52685196	52685196	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcggccgggccgcggcccGcaggccgagatgcagctgaa	7	2	17	15	6	0	2	0	1	0	1	0	3	0	2	4	4	3	3	4	4	1	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:52685196G>A	uc001sab.2	-	1	104	c.54C>T	c.(52-54)TGC>TGT	p.C18C	KRT86_uc010snq.1_Intron|KRT86_uc009zmg.2_Intron|KRT81_uc001sac.2_Intron	NM_002281	NP_002272	Q14533	KRT81_HUMAN	keratin, hair, basic, 1	18	Head.					keratin filament	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCGCGGCCCGCAGGCCGAGA	0.692													10	9					0	0	0	0	A	52685196	A	A	52685196	2	1	98	1	0	0	0	0	0	0	0	1	8534	1079	38	1		1	KRT81	12	52685196	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	12003889	52685196	81166699	92	18823											
PCBP2	5094	broad.mit.edu	37	chr12	53849719	53849719	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattgtcctgagagaattatCactttggctggacccactaa	12	12	8	9	0	1	2	1	1	0	1	2	4	2	3	2	2	0	1	2	2	4	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:53849719C>T	uc001sdl.3	+	5	527	c.177C>T	c.(175-177)ATC>ATT	p.I59I	PCBP2_uc001sdc.3_Silent_p.I59I|PCBP2_uc001sdb.3_Silent_p.I59I|PCBP2_uc001sde.3_Silent_p.I59I|PCBP2_uc001sdi.3_Silent_p.I59I|PCBP2_uc001sdd.3_Silent_p.I59I|PCBP2_uc001sdf.3_Silent_p.I59I|PCBP2_uc009zna.2_Intron|PCBP2_uc010soh.1_Silent_p.I59I|PCBP2_uc009zmz.1_Intron	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	59	KH 1.				innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						AGAGAATTATCACTTTGGCTG	0.403													47	137					0	0	0	0	T	53849719	T	T	53849719	2	4	98	1	0	0	0	0	0	0	0	1	11555	816	29	2		2	PCBP2	12	53849719	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	1164523	53849719	80002176	93	18824											
ITGA5	3678	broad.mit.edu	37	chr12	54797970	54797970	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctgcagctccgctcctcTgggttgaacatggcggggaa	8	8	14	11	2	1	1	0	1	1	0	3	2	3	2	2	4	4	5	2	4	3	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:54797970T>A	uc001sga.2	-	15	1592	c.1524A>T	c.(1522-1524)CCA>CCT	p.P508P		NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	508	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						TCCGCTCCTCTGGGTTGAACA	0.612											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	48					0	0	0	0	A	54797970	A	A	54797970	2	1	98	1	0	0	0	0	0	0	0	1	7918	1567	55	5		5	ITGA5	12	54797970	Silent	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	948251	54797970	79053925	94	18825											
LRP1	4035	broad.mit.edu	37	chr12	57588203	57588203	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcttccagccctgcgagcGgacctcactctgctacgcac	6	8	9	18	3	3	0	1	0	2	0	4	2	4	1	3	1	5	3	3	1	1	2	rs146710883	by1000genomes	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:57588203G>T	uc001snd.2	+	49	8451	c.7985G>T	c.(7984-7986)CGG>CTG	p.R2662L	MIR1228_hsa-mir-1228|MI0006318_5'Flank	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2662	LDL-receptor class A 14.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCTGCGAGCGGACCTCACTC	0.662													61	71					1.53716e-24	1.76168e-24	1	0	T	57588203	T	T	57588203	3	4	98	1	0	0	0	0	1	0	0	0	9001	1116	39	3	8179	3	LRP1	12	57588203	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	2790233	57588203	76263692	95	18826											
PTPRB	5787	broad.mit.edu	37	chr12	70954686	70954686	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctgtcgtgttccgattggaCcccctgagatgactcacaga	8	11	10	12	2	2	3	1	2	1	2	4	6	3	4	3	1	0	1	3	1	0	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:70954686C>A	uc001swb.3	-	15	3573	c.3543G>T	c.(3541-3543)GGG>GGT	p.G1181G	PTPRB_uc010sto.1_Silent_p.G1091G|PTPRB_uc010stp.1_Silent_p.G1091G|PTPRB_uc001swc.3_Silent_p.G1399G|PTPRB_uc001swa.3_Silent_p.G1311G|PTPRB_uc001swd.3_Silent_p.G1398G|PTPRB_uc009zrr.1_Silent_p.G1278G	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1181	Fibronectin type-III 14.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCCGATTGGACCCCCTGAGAT	0.458													23	63					2.44723e-14	2.65551e-14	1	0	A	70954686	A	A	70954686	2	1	98	1	0	0	0	0	0	0	0	1	12861	494	18	4		4	PTPRB	12	70954686	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	13366483	70954686	62897209	96	18827											
TRHDE	29953	broad.mit.edu	37	chr12	72866930	72866930	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cactactttgaatttgttggTacagactacctctatcctgg	9	15	7	10	0	1	2	0	1	1	1	2	2	2	2	2	2	3	2	2	2	5	7			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:72866930T>C	uc001sxa.2	+	5	1449	c.1419T>C	c.(1417-1419)GGT>GGC	p.G473G		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	473	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						AATTTGTTGGTACAGACTACC	0.423													37	36					0	0	0	0	C	72866930	C	C	72866930	2	2	98	1	0	0	0	0	0	0	0	1	16546	1625	57	5		5	TRHDE	12	72866930	Silent	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	1912244	72866930	60984965	97	18828											
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100441863	100441865	+	In_Frame_Del	DEL	AAT	-	-																															tttctatgtggcactgcagaAatccatttttttctgcaagt																										TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:100441863_100441865delAAT	uc001tgq.2	-	18	4057_4059	c.3828_3830delATT	c.(3826-3831)GGATTT>GGT	p.F1277del	UHRF1BP1L_uc001tgp.2_In_Frame_Del_p.F927del	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	1277										ovary(2)	2						GCACTGCAGAAATCCATTTTTTT	0.365													---	---	---								-	100441865	-	-	100441863	7	5	98	1	0	1	0	1	0	0	0	0	17037	14	1	0	580	0	UHRF1BP1L	12	100441863	In_Frame_Del	DEL	AAT	TCGA-CQ-5332-01A-01D-1683-08	27574933	100441863	33410032	98	18829											
PAH	5053	broad.mit.edu	37	chr12	103248914	103248914	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccctgatgtggacttacTctgcaggaactgagaaacgt	11	10	11	9	1	1	3	0	3	1	1	1	6	1	5	1	2	4	1	1	2	3	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:103248914T>A	uc001tjq.1	-	7	1178	c.706A>T	c.(706-708)ACT>TCT	p.T236S	PAH_uc010swc.1_Missense_Mutation_p.S236C	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	236					catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	GTGGACTTACTCTGCAGGAAC	0.468													15	22					0	0	0	0	A	103248914	A	A	103248914	3	1	98	1	0	0	0	0	1	0	0	0	11448	1565	54	5	684	5	PAH	12	103248914	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	2807051	103248914	30602981	99	18830											
TBX3	6926	broad.mit.edu	37	chr12	115109730	115109730	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcagttcgctggtggcCgcctctttctccgcgcagag	3	11	12	15	4	3	1	0	0	3	1	5	1	3	1	3	2	1	4	3	2	0	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:115109730C>T	uc001tvt.1	-	8	3112	c.2148G>A	c.(2146-2148)GCG>GCA	p.A716A	TBX3_uc001tvu.1_Silent_p.A696A	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	716					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		CGCTGGTGGCCGCCTCTTTCT	0.652													4	5					0	0	0	0	T	115109730	T	T	115109730	2	4	98	1	0	0	0	0	0	0	0	1	15725	639	23	1		1	TBX3	12	115109730	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	11860816	115109730	18742165	100	18831											
RFC5	5985	broad.mit.edu	37	chr12	118456893	118456893	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcagggttgaaaaataccggCcacagaccctgaatgatctc	13	8	9	11	1	2	4	1	3	1	1	3	4	2	4	3	2	1	1	3	2	4	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr12:118456893C>A	uc001twq.2	+	2	207	c.82C>A	c.(82-84)CCA>ACA	p.P28T	RFC5_uc010syx.1_Missense_Mutation_p.P7T|RFC5_uc010syy.1_Missense_Mutation_p.P7T|RFC5_uc010syz.1_5'UTR|RFC5_uc009zwr.2_Missense_Mutation_p.P28T	NM_007370	NP_031396	P40937	RFC5_HUMAN	replication factor C 5 isoform 1	28					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAAATACCGGCCACAGACCCT	0.338													25	38					1.1804e-14	1.28771e-14	1	0	A	118456893	A	A	118456893	3	1	98	1	0	0	0	0	1	0	0	0	13313	739	26	4	94	4	RFC5	12	118456893	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	3347163	118456893	15395002	101	18832											
SACS	26278	broad.mit.edu	37	chr13	23905170	23905170	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagtcttgtggctctctctaCcagagaaaagaggaggaatg	13	9	12	7	0	3	2	0	0	3	2	4	5	3	4	1	3	1	1	1	3	5	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr13:23905170C>G	uc001uon.2	-	10	13434	c.12845G>C	c.(12844-12846)GGT>GCT	p.G4282A	SACS_uc001uoo.2_Missense_Mutation_p.G4135A|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4282					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GCTCTCTCTACCAGAGAAAAG	0.478													44	37					0	0	0	0	G	23905170	G	G	23905170	3	3	98	1	0	0	0	0	1	0	0	0	13869	507	18	4	898	4	SACS	13	23905170	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08		23905170	91264708	102	18833											
SACS	26278	broad.mit.edu	37	chr13	23915744	23915744	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgaacaatcaattctctGccaggccagaatgtattcat	13	12	6	10	0	3	2	2	1	1	1	4	2	3	2	2	1	2	1	2	1	5	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr13:23915744G>C	uc001uon.2	-	10	2860	c.2271C>G	c.(2269-2271)GGC>GGG	p.G757G	SACS_uc001uoo.2_Silent_p.G610G|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Silent_p.G610G	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	757					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TCAATTCTCTGCCAGGCCAGA	0.363													14	73					0	0	0	0	C	23915744	C	C	23915744	2	2	98	1	0	0	0	0	0	0	0	1	13869	1306	46	4		4	SACS	13	23915744	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	10574	23915744	91254134	103	18834											
KLF12	11278	broad.mit.edu	37	chr13	74420023	74420023	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caatagtgttgttcacatttCcaggtgaccttacagctgtg	9	14	9	9	0	1	1	1	1	0	0	2	1	2	1	2	1	2	3	2	1	3	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr13:74420023C>G	uc001vjf.2	-	4	833	c.611G>C	c.(610-612)GGA>GCA	p.G204A	KLF12_uc010aeq.2_Missense_Mutation_p.G204A|KLF12_uc001vjg.3_Missense_Mutation_p.G204A	NM_007249	NP_009180	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	204					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		GTTCACATTTCCAGGTGACCT	0.468													26	34					0	0	0	0	G	74420023	G	G	74420023	3	3	98	1	0	0	0	0	1	0	0	0	8379	855	30	2	617	2	KLF12	13	74420023	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	50504279	74420023	40749855	104	18835											
LMO7	4008	broad.mit.edu	37	chr13	76395471	76395471	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagcaacttatccttcagAaattcccaaagaagattcta	15	10	7	9	0	2	3	1	0	1	3	4	4	4	4	2	1	2	1	2	1	6	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr13:76395471A>G	uc001vjv.2	+	11	2427	c.1667A>G	c.(1666-1668)GAA>GGA	p.E556G	LMO7_uc010thv.1_Missense_Mutation_p.E507G|LMO7_uc001vjt.1_Missense_Mutation_p.E455G|LMO7_uc010thw.1_Missense_Mutation_p.E406G|LMO7_uc001vjw.1_Missense_Mutation_p.E462G	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	841						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TATCCTTCAGAAATTCCCAAA	0.448													12	37					0	0	0	0	G	76395471	G	G	76395471	3	3	98	1	0	0	0	0	1	0	0	0	8897	246	9	5	2580	5	LMO7	13	76395471	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	1975448	76395471	38774407	105	18836											
HS6ST3	266722	broad.mit.edu	37	chr13	97485361	97485361	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaggagcggaggctgcagcGagagcacagggaccaccagt	11	2	18	10	2	0	1	0	0	0	1	0	6	0	5	2	5	4	3	2	5	0	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr13:97485361G>A	uc001vmw.2	+	2	1349	c.1325G>A	c.(1324-1326)CGA>CAA	p.R442Q		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	442	Lumenal (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					AGGCTGCAGCGAGAGCACAGG	0.612													18	32					0	0	0	0	A	97485361	A	A	97485361	3	1	98	1	0	0	0	0	1	0	0	0	7411	1058	37	1	1331	1	HS6ST3	13	97485361	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	21089890	97485361	17684517	106	18837											
OR4K15	81127	broad.mit.edu	37	chr14	20444015	20444015	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcagactttctggttgagcGcaagactatttcttttgatg	8	16	10	7	1	2	4	0	2	2	2	2	4	2	4	0	1	2	3	0	1	2	6	rs139377821	by1000genomes	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:20444015G>A	uc010tkx.1	+	1	338	c.338G>A	c.(337-339)CGC>CAC	p.R113H		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	113	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGGTTGAGCGCAAGACTATT	0.453													36	41					0	0	0	0	A	20444015	A	A	20444015	3	1	98	1	0	0	0	0	1	0	0	0	11124	1087	38	1	340	1	OR4K15	14	20444015	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08		20444015	86905525	107	18838											
SPTB	6710	broad.mit.edu	37	chr14	65260353	65260353	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaaggccttgtgcttgcgCtgtaagatgagcacactggt	9	11	12	9	1	1	2	1	1	0	1	1	2	1	2	1	2	3	4	1	2	2	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:65260353C>T	uc001xht.2	-	13	2082	c.2028G>A	c.(2026-2028)CAG>CAA	p.Q676Q	SPTB_uc001xhr.2_Silent_p.Q676Q|SPTB_uc001xhs.2_Silent_p.Q676Q|SPTB_uc001xhu.2_Silent_p.Q676Q	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	676	Spectrin 4.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGTGCTTGCGCTGTAAGATGA	0.547													19	20					0	0	0	0	T	65260353	T	T	65260353	2	4	98	1	0	0	0	0	0	0	0	1	15184	796	28	4		4	SPTB	14	65260353	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	44816338	65260353	42089187	108	18839											
COX16	51241	broad.mit.edu	37	chr14	70795912	70795912	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatattccgactctaaagaTattttattctctttcagttt	10	20	3	8	1	4	1	2	0	2	1	6	2	5	1	1	0	0	1	1	0	5	9			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:70795912T>C	uc001xmb.2	-	3	323	c.183A>G	c.(181-183)ATA>ATG	p.I61M		NM_016468	NP_057552	Q9P0S2	COX16_HUMAN	COX16 cytochrome c oxidase assembly homolog	61						integral to membrane|mitochondrial membrane					0						ACTCTAAAGATATTTTATTCT	0.303													8	17					0	0	0	0	C	70795912	C	C	70795912	3	2	98	1	0	0	0	0	1	0	0	0	3780	1396	49	5	145	5	COX16	14	70795912	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	5535559	70795912	36553628	109	18840											
BATF	10538	broad.mit.edu	37	chr14	76012935	76012935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggtgctggccgccagcaCgccctcgccccccgaggtgg	3	5	14	19	5	0	0	0	0	0	0	2	1	0	0	6	4	2	2	6	4	0	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:76012935C>T	uc001xrr.2	+	3	541	c.299C>T	c.(298-300)ACG>ATG	p.T100M		NM_006399	NP_006390	Q16520	BATF_HUMAN	basic leucine zipper transcription factor,	100						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.028)		GCCGCCAGCACGCCCTCGCCC	0.642													8	9					0	0	0	0	T	76012935	T	T	76012935	3	4	98	1	0	0	0	0	1	0	0	0	1327	536	19	1	309	1	BATF	14	76012935	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	5217023	76012935	31336605	110	18841											
TC2N	123036	broad.mit.edu	37	chr14	92249476	92249476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taatttgtgccacctgataaCaaccttttctggatttatta	11	17	5	8	0	1	1	0	1	1	0	1	2	1	2	3	1	3	0	3	1	5	8			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:92249476C>T	uc001xzu.3	-	12	1632	c.1441G>A	c.(1441-1443)GTT>ATT	p.V481I	TC2N_uc001xzt.3_Missense_Mutation_p.V481I|TC2N_uc010auc.2_Missense_Mutation_p.V417I|TC2N_uc001xzv.3_Missense_Mutation_p.V481I	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	481						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		CACCTGATAACAACCTTTTCT	0.328													32	113					0	0	0	0	T	92249476	T	T	92249476	3	4	98	1	0	0	0	0	1	0	0	0	15731	478	17	4	35	4	TC2N	14	92249476	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	16236541	92249476	15100064	111	18842											
KIAA1409	57578	broad.mit.edu	37	chr14	94088956	94088956	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctcctcaaagttcccgaaGatgcagagaaccccacagaa	14	6	7	14	1	1	3	1	0	0	3	4	5	4	3	5	0	2	2	5	0	4	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr14:94088956G>C	uc001ybv.1	+	28	4995	c.4912G>C	c.(4912-4914)GAT>CAT	p.D1638H	KIAA1409_uc001ybs.1_Missense_Mutation_p.D1616H	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1793						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AGTTCCCGAAGATGCAGAGAA	0.542													25	41					0	0	0	0	C	94088956	C	C	94088956	3	2	98	1	0	0	0	0	1	0	0	0	8269	942	33	2	4952	2	KIAA1409	14	94088956	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	1839480	94088956	13260584	112	18843											
HERC2	8924	broad.mit.edu	37	chr15	28419625	28419625	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggccacatccacagttgTccacgccacactgtgggacg	8	7	11	15	3	0	0	0	0	0	0	2	1	2	1	4	2	0	1	4	2	0	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr15:28419625T>G	uc001zbj.2	-	65	10079	c.9973A>C	c.(9973-9975)ACA>CCA	p.T3325P		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3325	RCC1 12.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TCCACAGTTGTCCACGCCACA	0.557													14	29					0	0	0	0	G	28419625	G	G	28419625	3	3	98	1	0	0	0	0	1	0	0	0	7097	1667	58	5	4647	5	HERC2	15	28419625	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08		28419625	74111767	113	18844											
PLA2G4F	255189	broad.mit.edu	37	chr15	42439887	42439887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaaggccgagctcctgcaacCctgccaggctgccgtacaga	9	5	12	15	2	0	1	0	0	0	1	1	3	1	1	5	2	6	4	5	2	3	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr15:42439887C>T	uc001zoz.2	-	12	1196	c.1133G>A	c.(1132-1134)GGG>GAG	p.G378E	PLA2G4F_uc010bcq.2_5'Flank|PLA2G4F_uc001zoy.2_Missense_Mutation_p.G10E|PLA2G4F_uc010bcr.2_Missense_Mutation_p.G129E|PLA2G4F_uc001zpa.2_Missense_Mutation_p.G129E|PLA2G4F_uc010bcs.2_Missense_Mutation_p.G165E	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	378	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CTCCTGCAACCCTGCCAGGCT	0.577													27	76					0	0	0	0	T	42439887	T	T	42439887	3	4	98	1	0	0	0	0	1	0	0	0	12061	623	22	4	1452	4	PLA2G4F	15	42439887	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	14020262	42439887	60091505	114	18845											
ATP8B4	79895	broad.mit.edu	37	chr15	50211036	50211036	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatccattttcaagttacCttgtttgtctcctgttagga	9	17	6	9	0	2	0	1	0	1	0	4	1	3	1	3	1	2	3	3	1	4	6			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr15:50211036C>A	uc001zxu.2	-	19	2177	c.2035G>T	c.(2035-2037)GAA>TAA	p.E679*	ATP8B4_uc010ber.2_Nonsense_Mutation_p.E552*|ATP8B4_uc010ufd.1_Nonsense_Mutation_p.E489*|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	679	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTCAAGTTACCTTGTTTGTCT	0.318													15	56					1.15088e-07	1.20399e-07	1	0	A	50211036	A	A	50211036	4	1	98	1	0	0	0	0	0	1	0	0	1199	695	24	4	1583	4	ATP8B4	15	50211036	Nonsense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	7771149	50211036	52320356	115	18846											
IL16	3603	broad.mit.edu	37	chr15	81591957	81591957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaccaaagctggacaccGccaatggcactcccaaagtt	12	5	7	17	1	0	0	0	0	0	0	1	1	1	1	6	2	1	3	6	2	3	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr15:81591957G>A	uc002bgh.3	+	14	2666	c.2290G>A	c.(2290-2292)GCC>ACC	p.A764T	IL16_uc010blq.1_Missense_Mutation_p.A718T|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.A806T|IL16_uc002bgg.2_Missense_Mutation_p.A764T|IL16_uc002bgi.1_Missense_Mutation_p.A154T|IL16_uc002bgj.2_Missense_Mutation_p.A258T|IL16_uc002bgk.2_Missense_Mutation_p.A63T|IL16_uc002bgl.1_Missense_Mutation_p.A63T|IL16_uc010unq.1_Missense_Mutation_p.A63T	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	764					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GCTGGACACCGCCAATGGCAC	0.557													30	22					0	0	0	0	A	81591957	A	A	81591957	3	1	98	1	0	0	0	0	1	0	0	0	7672	1087	38	1	2340	1	IL16	15	81591957	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	31380921	81591957	20939435	116	18847											
TMEM8A	58986	broad.mit.edu	37	chr16	424221	424221	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggaggggccagcctacCgtggagaagaacatggtgta	11	6	16	8	1	0	2	0	0	0	2	0	4	0	3	3	5	4	2	3	5	4	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:424221C>T	uc002cgu.3	-	10	1884	c.1755G>A	c.(1753-1755)ACG>ACA	p.T585T	TMEM8A_uc002cgv.3_Silent_p.T392T	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	585	Helical; (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3						GCCAGCCTACCGTGGAGAAGA	0.662											OREG0003702	type=REGULATORY REGION|Gene=TMEM8|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	15	34					0	0	0	0	T	424221	T	T	424221	2	4	98	1	0	0	0	0	0	0	0	1	16280	666	23	1		1	TMEM8A	16	424221	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08		424221	89930532	117	18848											
NOXO1	124056	broad.mit.edu	37	chr16	2031220	2031220	+	5'Flank	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagattcctgaaatgggcgaGgacccttctgcctccccgtg	7	9	11	14	2	1	2	0	1	1	1	3	4	3	3	5	2	1	0	5	2	1	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:2031220G>T	uc002cnx.2	-						NOXO1_uc002cnz.2_5'UTR|NOXO1_uc002coa.2_5'UTR|NOXO1_uc002cny.2_5'Flank|GFER_uc002cob.2_5'Flank	NM_172168	NP_751908	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1 isoform c						cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity				0						AAATGGGCGAGGACCCTTCTG	0.617													13	21					1.3612e-06	1.40957e-06	1	0	T	2031220	T	T	2031220	1	4	98	0	1	0	0	0	0	0	0	0	10615	1015	35	4		4	NOXO1	16	2031220	5'Flank	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	1606999	2031220	88323533	118	18849											
CARHSP1	23589	broad.mit.edu	37	chr16	8952230	8952230	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagatgtgcaggaagatgtcGgggccgccatcagctggagt	9	7	17	8	2	1	2	1	0	0	2	2	5	1	4	2	4	2	2	2	4	1	0	rs141833541	byFrequency	TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:8952230G>A	uc002czh.1	-	3	608	c.258C>T	c.(256-258)CCC>CCT	p.P86P	PMM2_uc002czg.1_Intron|CARHSP1_uc002czi.1_Silent_p.P86P	NM_001042476	NP_001035941	Q9Y2V2	CHSP1_HUMAN	calcium-regulated heat-stable protein 1	86	CSD.				intracellular signal transduction|regulation of mRNA stability|regulation of transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|P granule	DNA binding|mRNA 3'-UTR binding|phosphatase binding				0						GGAAGATGTCGGGGCCGCCAT	0.632													10	21					0	0	0	0	A	8952230	A	A	8952230	2	1	98	1	0	0	0	0	0	0	0	1	2665	1103	39	1		1	CARHSP1	16	8952230	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	6921010	8952230	81402523	119	18850											
ACSM2B	348158	broad.mit.edu	37	chr16	20570634	20570634	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactgccacacgatccccacGctgcaggccacaggctcccg	8	4	9	20	3	0	0	0	0	0	0	2	1	2	0	5	2	2	3	5	2	0	0	rs141121285		TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:20570634G>A	uc002dhj.3	-	4	523	c.313C>T	c.(313-315)CGT>TGT	p.R105C	ACSM2B_uc002dhk.3_Missense_Mutation_p.R105C|ACSM2B_uc010bwf.1_Missense_Mutation_p.R105C	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	105					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CGATCCCCACGCTGCAGGCCA	0.567													16	18					0	0	0	0	A	20570634	A	A	20570634	3	1	98	1	0	0	0	0	1	0	0	0	184	1087	38	1	1468	1	ACSM2B	16	20570634	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	11618404	20570634	69784119	120	18851											
IL21R	50615	broad.mit.edu	37	chr16	27460487	27460487	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttgtgggctctgactgcagCagccctgtggagtgtgactt	5	13	14	9	0	1	2	0	2	1	0	1	3	1	3	1	2	3	3	1	2	0	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:27460487C>A	uc002doq.1	+	9	1733	c.1500C>A	c.(1498-1500)AGC>AGA	p.S500R	IL21R_uc002dor.1_Missense_Mutation_p.S500R|IL21R_uc002dos.1_Missense_Mutation_p.S500R|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	500	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						CTGACTGCAGCAGCCCTGTGG	0.657			T	BCL6	NHL								16	59					4.7546e-09	5.05177e-09	1	0	A	27460487	A	A	27460487	3	1	98	1	0	0	0	0	1	0	0	0	7710	709	25	4	1530	4	IL21R	16	27460487	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	6889853	27460487	62894266	121	18852											
CNOT1	23019	broad.mit.edu	37	chr16	58571071	58571071	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttgggcctccatgagcaCgatcaatcattgcttcatag	10	12	9	10	1	3	1	3	1	0	0	4	2	4	1	2	1	2	3	2	1	2	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:58571071C>T	uc002env.2	-	39	5761	c.5468G>A	c.(5467-5469)CGT>CAT	p.R1823H	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.R1818H|CNOT1_uc010vik.1_Missense_Mutation_p.R780H	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1823					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TCCATGAGCACGATCAATCAT	0.468													9	95					0	0	0	0	T	58571071	T	T	58571071	3	4	98	1	0	0	0	0	1	0	0	0	3632	536	19	1	1706	1	CNOT1	16	58571071	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	31110584	58571071	31783682	122	18853											
LRRC36	55282	broad.mit.edu	37	chr16	67409205	67409205	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctggaaaccacagtccccCcatctctgccagaacccccc	9	5	7	20	0	1	1	0	0	1	1	3	2	2	2	8	2	3	1	8	2	2	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:67409205C>A	uc002esv.2	+	10	1569	c.1550C>A	c.(1549-1551)CCC>CAC	p.P517H	LRRC36_uc002esw.2_Intron|LRRC36_uc002esx.2_Missense_Mutation_p.P396H|LRRC36_uc010vjk.1_Intron|LRRC36_uc010vjl.1_Missense_Mutation_p.P38T|LRRC36_uc002esy.2_Missense_Mutation_p.P27H	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	517											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		CACAGTCCCCCCATCTCTGCC	0.512													111	194					9.1649e-64	1.06837e-63	1	0	A	67409205	A	A	67409205	3	1	98	1	0	0	0	0	1	0	0	0	9040	623	22	4	1616	4	LRRC36	16	67409205	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	8838134	67409205	22945548	123	18854											
ADAMTS18	170692	broad.mit.edu	37	chr16	77327019	77327019	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagccggctgttcttggggCatcgtccaagcacacagccc	7	8	12	14	2	1	0	0	0	1	0	3	0	2	0	3	3	3	5	3	3	2	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr16:77327019C>A	uc002ffc.3	-	20	3562	c.3143G>T	c.(3142-3144)TGC>TTC	p.C1048F	ADAMTS18_uc010chc.1_Missense_Mutation_p.C636F	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1048	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GTTCTTGGGGCATCGTCCAAG	0.507													30	78					5.09552e-08	5.35818e-08	1	0	A	77327019	A	A	77327019	3	1	98	1	0	0	0	0	1	0	0	0	263	710	25	4	538	4	ADAMTS18	16	77327019	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	9917814	77327019	13027734	124	18855											
KIAA0753	9851	broad.mit.edu	37	chr17	6493123	6493139	+	Frame_Shift_Del	DEL	AAGGAGCCTACAGCCTC	-	-																															cagctatcagccacgggttgAaggagcctacagcctcatga																										TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:6493123_6493139delAAGGAGCCTACAGCCTC	uc002gde.3	-	18	3105_3121	c.2746_2762delGAGGCTGTAGGCTCCTT	c.(2746-2763)GAGGCTGTAGGCTCCTTCfs	p.E916fs	KIAA0753_uc010vtd.1_Frame_Shift_Del_p.E372fs|KIAA0753_uc010clo.2_Frame_Shift_Del_p.E617fs|KIAA0753_uc010vte.1_Frame_Shift_Del_p.E617fs	NM_014804	NP_055619	Q2KHM9	K0753_HUMAN	hypothetical protein LOC9851	916_921						centrosome					0				COAD - Colon adenocarcinoma(228;0.157)		CCACGGGTTGAAGGAGCCTACAGCCTCATGAGATATG	0.47													---	---	---								-	6493139	-	-	6493123	7	5	98	1	0	1	0	1	0	0	0	0	8230	246	9	0	149	0	KIAA0753	17	6493123	Frame_Shift_Del	DEL	AAGGAGCCTACAGCCTC	TCGA-CQ-5332-01A-01D-1683-08		6493123	74702087	125	18856											
DLG4	1742	broad.mit.edu	37	chr17	7122262	7122262	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgtgagtaaagtaggccGtctctgagccgaccagctgt	9	9	13	10	2	1	2	0	2	1	0	2	3	1	2	3	1	3	4	3	1	3	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:7122262G>A	uc002get.3	-	1	1108	c.-93C>T	c.(-95--91)GACGG>GATGG		DLG4_uc010cly.2_5'Flank|DLG4_uc010vto.1_Translation_Start_Site|DLG4_uc002geu.2_5'Flank|ACADVL_uc010vtp.1_Intron|ACADVL_uc010vtq.1_5'Flank|ACADVL_uc002gev.2_5'Flank|ACADVL_uc002gew.2_5'Flank|ACADVL_uc002gex.2_5'Flank	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1						axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						AAAGTAGGCCGTCTCTGAGCC	0.567													5	10					0	0	0	0	A	7122262	A	A	7122262	1	1	98	1	0	0	0	0	0	0	0	0	4579	1160	40	1		1	DLG4	17	7122262	Translation_Start_Site	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	629139	7122262	74072948	126	18857											
TP53	7157	broad.mit.edu	37	chr17	7578479	7578479	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gacgcgggtgccgggcggggGtgtggaatcaacccacagct	7	5	18	11	4	1	0	1	0	0	0	1	2	1	1	2	5	3	1	2	5	2	0	rs28934874		TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:7578479G>A	uc002gim.2	-	5	645	c.451C>T	c.(451-453)CCC>TCC	p.P151S	TP53_uc002gig.1_Missense_Mutation_p.P151S|TP53_uc002gih.2_Missense_Mutation_p.P151S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P19S|TP53_uc010cng.1_Missense_Mutation_p.P19S|TP53_uc002gii.1_Missense_Mutation_p.P19S|TP53_uc010cnh.1_Missense_Mutation_p.P151S|TP53_uc010cni.1_Missense_Mutation_p.P151S|TP53_uc002gij.2_Missense_Mutation_p.P151S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P58S|TP53_uc002gio.2_Missense_Mutation_p.P19S|TP53_uc010vug.1_Missense_Mutation_p.P112S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	151	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.P151H(25)|p.P151T(13)|p.P151P(12)|p.P151A(10)|p.P152fs*18(9)|p.0?(7)|p.P151fs*30(7)|p.P151L(6)|p.P151R(6)|p.T150fs*16(3)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P58A(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P19A(1)|p.P152fs*14(1)|p.T150_P151delTP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGGCGGGGGTGTGGAATCA	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			52	21					0	0	0	0	A	7578479	A	A	7578479	3	1	98	1	0	0	0	0	1	0	0	0	16448	1261	44	4	847	4	TP53	17	7578479	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	456217	7578479	73616731	127	18858											
MYH4	4622	broad.mit.edu	37	chr17	10368799	10368799	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcattgtcagagatggagaaGatatggggtggggcctcctg	9	9	17	6	0	1	3	1	0	0	3	2	5	2	3	2	5	0	1	2	5	2	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:10368799G>A	uc002gmn.2	-	5	576	c.465C>T	c.(463-465)ATC>ATT	p.I155I	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	155	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AGATGGAGAAGATATGGGGTG	0.478													54	107					0	0	0	0	A	10368799	A	A	10368799	2	1	98	1	0	0	0	0	0	0	0	1	10090	932	33	2		2	MYH4	17	10368799	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	2790320	10368799	70826411	128	18859											
ADAP2	55803	broad.mit.edu	37	chr17	29253865	29253865	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttatgatccacaatggaaaCctccgtgtgaaggccaagtt	12	11	9	9	1	0	2	0	2	0	0	2	3	2	3	4	2	1	1	4	2	5	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:29253865C>T	uc002hfx.2	+	3	525	c.246C>T	c.(244-246)AAC>AAT	p.N82N	ADAP2_uc010csk.2_Silent_p.N88N|ADAP2_uc002hfy.2_Silent_p.N82N|ADAP2_uc010csl.2_RNA	NM_018404	NP_060874	Q9NPF8	ADAP2_HUMAN	centaurin-alpha 2 protein	82	Arf-GAP.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		ovary(1)	1						ACAATGGAAACCTCCGTGTGA	0.478													21	41					0	0	0	0	T	29253865	T	T	29253865	2	4	98	1	0	0	0	0	0	0	0	1	280	506	18	4		4	ADAP2	17	29253865	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	18885066	29253865	51941345	129	18860											
SAMD14	201191	broad.mit.edu	37	chr17	48192980	48192980	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgtgtttaggggagcaggtgGgggaggtggtgctacccgag	6	8	21	6	2	0	0	0	0	0	0	0	3	0	2	1	7	3	3	1	7	2	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:48192980G>T	uc002iqg.2	-	7	1069	c.770C>A	c.(769-771)CCC>CAC	p.P257H	SAMD14_uc002iqd.2_Missense_Mutation_p.P40H|SAMD14_uc002iqe.2_Missense_Mutation_p.P40H|SAMD14_uc002iqf.2_Missense_Mutation_p.P257H	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	257											0						GGAGCAGGTGGGGGAGGTGGT	0.622													52	118					9.55421e-19	1.07683e-18	1	0	T	48192980	T	T	48192980	3	4	98	1	0	0	0	0	1	0	0	0	13884	1232	43	4	587	4	SAMD14	17	48192980	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	18939115	48192980	33002230	130	18861											
RNF213	57674	broad.mit.edu	37	chr17	78355470	78355470	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccgacgagaccatcggcGtggtccacctcgtcctgcgc	5	7	13	16	6	0	1	0	0	0	1	4	3	2	1	5	2	2	0	5	2	0	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr17:78355470G>A	uc002jyh.1	+	32	8363	c.8140G>A	c.(8140-8142)GTG>ATG	p.V2714M	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.V1096M	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GACCATCGGCGTGGTCCACCT	0.597													7	32					0	0	0	0	A	78355470	A	A	78355470	3	1	98	1	0	0	0	0	1	0	0	0	13542	1145	40	1	14462	1	RNF213	17	78355470	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	30162490	78355470	2839740	131	18862											
LAMA1	284217	broad.mit.edu	37	chr18	7050890	7050890	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caaaatccagtttccaggtcGaggggcattggcagctttaa	11	10	11	9	1	0	0	0	0	0	0	3	1	2	0	2	4	1	4	2	4	3	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr18:7050890G>A	uc002knm.2	-	4	485	c.391C>T	c.(391-393)CGA>TGA	p.R131*	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	131	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTCCAGGTCGAGGGGCATTG	0.423													21	45					0	0	0	0	A	7050890	A	A	7050890	4	1	98	1	0	0	0	0	0	1	0	0	8645	1066	37	1	9076	1	LAMA1	18	7050890	Nonsense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08		7050890	71026358	132	18863											
SETBP1	26040	broad.mit.edu	37	chr18	42532422	42532422	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccttttttacaagggttcagCtaccctattcccagtggaag	9	13	8	11	0	1	0	1	0	0	0	2	1	2	1	3	2	3	2	3	2	5	7			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr18:42532422C>G	uc010dni.2	+	4	3413	c.3117C>G	c.(3115-3117)AGC>AGG	p.S1039R		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1039						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AAGGGTTCAGCTACCCTATTC	0.448									Schinzel-Giedion_syndrome				12	34					0	0	0	0	G	42532422	G	G	42532422	3	3	98	1	0	0	0	0	1	0	0	0	14194	796	28	4	3320	4	SETBP1	18	42532422	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	35481532	42532422	35544826	133	18864											
CDH7	1005	broad.mit.edu	37	chr18	63481745	63481745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcagtggtacaagtgacagCgacggatgctgatgatccta	11	9	12	9	2	1	3	1	3	0	0	2	5	2	4	1	2	3	2	1	2	3	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr18:63481745C>T	uc002ljz.2	+	4	855	c.530C>T	c.(529-531)GCG>GTG	p.A177V	CDH7_uc002lka.2_Missense_Mutation_p.A177V|CDH7_uc002lkb.2_Missense_Mutation_p.A177V	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	177	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CAAGTGACAGCGACGGATGCT	0.438													28	89					0	0	0	0	T	63481745	T	T	63481745	3	4	98	1	0	0	0	0	1	0	0	0	3130	768	27	1	540	1	CDH7	18	63481745	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	20949323	63481745	14595503	134	18865											
SLC39A3	29985	broad.mit.edu	37	chr19	2733161	2733161	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcaaagaccgagtgggccGacagcgcgaaggccaggctg	10	3	15	13	4	1	1	1	0	0	1	1	4	1	1	4	3	1	1	4	3	2	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:2733161G>A	uc002lwg.2	-	3	787	c.533C>T	c.(532-534)TCG>TTG	p.S178L	SLC39A3_uc010xgy.1_Missense_Mutation_p.S178L	NM_144564	NP_653165	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter),	178	Helical; (Potential).					integral to membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGAGTGGGCCGACAGCGCGAA	0.721													18	47					0	0	0	0	A	2733161	A	A	2733161	3	1	98	1	0	0	0	0	1	0	0	0	14683	1059	37	1	415	1	SLC39A3	19	2733161	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08		2733161	56395822	135	18866											
MAP2K2	5605	broad.mit.edu	37	chr19	4117549	4117549	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttggctttctgggtgagAaaggcttccagccgcttctt	6	13	11	11	1	2	1	0	1	2	1	3	2	3	1	3	3	1	3	3	3	1	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:4117549A>C	uc002lzk.2	-	2	425	c.171T>G	c.(169-171)TTT>TTG	p.F57L		NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	57			F -> C (in CFC syndrome).		activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGGGTGAGAAAGGCTTCCA	0.597									Cardiofaciocutaneous_syndrome				28	46					0	0	0	0	C	4117549	C	C	4117549	3	2	98	1	0	0	0	0	1	0	0	0	9290	243	9	5	1071	5	MAP2K2	19	4117549	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	1384388	4117549	55011434	136	18867											
DENND1C	79958	broad.mit.edu	37	chr19	6468392	6468392	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctccagaccccaagaagctGctgtccagagcttcttctgc	8	10	8	15	0	3	3	0	0	3	3	5	3	4	3	4	0	4	3	4	0	2	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:6468392G>T	uc002mfe.2	-	22	1736	c.1644C>A	c.(1642-1644)AGC>AGA	p.S548R	DENND1C_uc002mfb.2_Missense_Mutation_p.S98R|DENND1C_uc002mfc.2_Missense_Mutation_p.S98R|DENND1C_uc002mfd.2_Missense_Mutation_p.S98R|DENND1C_uc010xje.1_Missense_Mutation_p.S504R	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	548						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						CCAAGAAGCTGCTGTCCAGAG	0.587													11	15					2.27111e-07	2.36381e-07	1	0	T	6468392	T	T	6468392	3	4	98	1	0	0	0	0	1	0	0	0	4450	1310	46	4	769	4	DENND1C	19	6468392	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	2350843	6468392	52660591	137	18868											
MUC16	94025	broad.mit.edu	37	chr19	9011414	9011414	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcccagtacagctgctctCtgttgagtccagggcttttg	5	13	11	12	0	1	1	0	1	1	0	4	1	3	1	2	1	3	6	2	1	1	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:9011414C>G	uc002mkp.2	-	36	39023	c.38819G>C	c.(38818-38820)AGA>ACA	p.R12940T	MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12942	SEA 6.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGCTGCTCTCTGTTGAGTCC	0.577													10	204					0	0	0	0	G	9011414	G	G	9011414	3	3	98	1	0	0	0	0	1	0	0	0	10026	913	32	2	4900	2	MUC16	19	9011414	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	2543022	9011414	50117569	138	18869											
CPAMD8	27151	broad.mit.edu	37	chr19	17088276	17088276	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcaggcgaccaagggggaCcatgctgggggtcacggcca	9	3	17	12	2	1	0	1	0	0	0	1	2	1	1	3	6	2	2	3	6	1	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:17088276C>G	uc002nfb.2	-	15	1833	c.1801G>C	c.(1801-1803)GTC>CTC	p.V601L		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	554						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CCAAGGGGGACCATGCTGGGG	0.587													13	34					0	0	0	0	G	17088276	G	G	17088276	3	3	98	1	0	0	0	0	1	0	0	0	3810	507	18	4	4109	4	CPAMD8	19	17088276	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	8076862	17088276	42040707	139	18870											
ZNF569	148266	broad.mit.edu	37	chr19	37904369	37904369	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgacttctcatatgtacagtAagggctgagctttgagagaa	12	12	11	6	0	1	4	1	3	1	1	2	5	1	4	0	1	2	4	0	1	4	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:37904369A>T	uc002ogi.2	-	6	1749	c.1191T>A	c.(1189-1191)CTT>CTA	p.L397L	ZNF569_uc002ogh.2_Silent_p.L238L|ZNF569_uc002ogj.2_Silent_p.L421L	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	397	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATGTACAGTAAGGGCTGAGC	0.383													9	77					0	0	0	0	T	37904369	T	T	37904369	2	4	98	1	0	0	0	0	0	0	0	1	18067	349	13	5		5	ZNF569	19	37904369	Silent	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	20816093	37904369	21224614	140	18871											
ZNF569	148266	broad.mit.edu	37	chr19	37917207	37917207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcacattccggtacagttttCtctgagcaggatccaatctc	9	13	7	12	1	3	1	1	1	2	0	7	2	5	2	2	2	2	3	2	2	2	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:37917207C>T	uc002ogi.2	-	4	647	c.89G>A	c.(88-90)AGA>AAA	p.R30K	ZNF569_uc002ogh.2_Intron|ZNF569_uc002ogj.2_Missense_Mutation_p.R54K	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	30	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTACAGTTTTCTCTGAGCAGG	0.388													27	36					0	0	0	0	T	37917207	T	T	37917207	3	4	98	1	0	0	0	0	1	0	0	0	18067	913	32	2	1983	2	ZNF569	19	37917207	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	12838	37917207	21211776	141	18872											
CYP2B6	1555	broad.mit.edu	37	chr19	41510326	41510326	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggaggaggctcagtgtctGatagaggagcttcggaaatc	11	8	15	7	1	2	2	1	1	1	1	4	6	2	6	0	5	1	2	0	5	2	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:41510326G>A	uc002opr.1	+	3	466	c.459G>A	c.(457-459)CTG>CTA	p.L153L	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Silent_p.L113L	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	153					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CTCAGTGTCTGATAGAGGAGC	0.517													13	13					0	0	0	0	A	41510326	A	A	41510326	2	1	98	1	0	0	0	0	0	0	0	1	4181	1277	45	2		2	CYP2B6	19	41510326	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	3593119	41510326	17618657	142	18873											
PSG7	5676	broad.mit.edu	37	chr19	43433689	43433689	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagtatagtttgtgacaccaAataggtagagggtcctgttg	11	12	12	6	0	0	2	0	1	0	1	1	2	1	2	2	2	0	4	2	2	5	6			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:43433689A>T	uc002ovl.3	-	4	716	c.614T>A	c.(613-615)TTT>TAT	p.F205Y	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_5'Flank|PSG7_uc002out.1_Missense_Mutation_p.F24Y|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.F83Y	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	205	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TGTGACACCAAATAGGTAGAG	0.522													151	242					0	0	0	0	T	43433689	T	T	43433689	3	4	98	1	0	0	0	0	1	0	0	0	12722	14	1	5	661	5	PSG7	19	43433689	Missense_Mutation	SNP	A	TCGA-CQ-5332-01A-01D-1683-08	1923363	43433689	15695294	143	18874											
ZNF549	256051	broad.mit.edu	37	chr19	58049113	58049114	+	Nonsense_Mutation	DNP	TA	AG	AG																															cacactggagaaaaagcttaTaagcgtagggaatatgggaa																										TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr19:58049113_58049114TA>AG	uc002qpb.1	+	4	990_991	c.741_742TA>AG	c.(739-744)TATAAG>TAAGAG	p.247_248YK>*E	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Nonsense_Mutation_p.234_235YK>*E	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	247_248	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAAAAGCTTATAAGCGTAGGGA	0.386													26	58					0	0	0	0	AG	58049114	AG	AG	58049113	4	1	98	1	0	0	0	0	0	1	0	0	18048	1413	49	5	712	5	ZNF549	19	58049113	Nonsense_Mutation	DNP	TA	TCGA-CQ-5332-01A-01D-1683-08	14615424	58049113	1079870	144	18875											
NKX2-2	4821	broad.mit.edu	37	chr20	21492699	21492699	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaaaagggaatgcccgcctgGaaggtggcggctgccaggtc	9	5	17	10	2	0	0	0	0	0	0	1	3	0	2	3	6	2	1	3	6	4	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:21492699G>T	uc002wsi.2	-	2	1041	c.684C>A	c.(682-684)TTC>TTA	p.F228L		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	228					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						TGCCCGCCTGGAAGGTGGCGG	0.682													27	42					1.16021e-09	1.23918e-09	1	0	T	21492699	T	T	21492699	3	4	98	1	0	0	0	0	1	0	0	0	10504	1165	41	2	141	2	NKX2-2	20	21492699	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08		21492699	41532821	145	18876											
NDRG3	57446	broad.mit.edu	37	chr20	35317165	35317165	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtgacgtggaccacaccaTgagttgtttctatatcatgt	10	14	9	8	1	2	2	1	2	1	0	2	3	2	3	2	1	0	2	2	1	3	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:35317165T>C	uc002xfw.2	-	4	198	c.116A>G	c.(115-117)CAT>CGT	p.H39R	NDRG3_uc002xfx.2_Missense_Mutation_p.H27R|NDRG3_uc010zvq.1_Intron|NDRG3_uc010zvr.1_Intron	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	39					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)				GACCACACCATGAGTTGTTTC	0.378													8	118					0	0	0	0	C	35317165	C	C	35317165	3	2	98	1	0	0	0	0	1	0	0	0	10307	1464	51	5	1063	5	NDRG3	20	35317165	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	13824466	35317165	27708355	146	18877											
SRC	6714	broad.mit.edu	37	chr20	36024685	36024685	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccgcacccagttcaacaGcctgcagcagctggtggcct	7	7	10	17	1	1	0	1	0	0	0	2	0	2	0	4	2	5	5	4	2	1	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:36024685G>T	uc002xgx.2	+	8	1123	c.674G>T	c.(673-675)AGC>ATC	p.S225I	SRC_uc002xgy.2_Missense_Mutation_p.S225I	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	225	SH2.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	CAGTTCAACAGCCTGCAGCAG	0.637													9	68					1.76689e-08	1.8676e-08	1	0	T	36024685	T	T	36024685	3	4	98	1	0	0	0	0	1	0	0	0	15200	971	34	4	692	4	SRC	20	36024685	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	707520	36024685	27000835	147	18878											
TP53RK	112858	broad.mit.edu	37	chr20	45315483	45315483	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttggaggaggtggagtagCtcttcagaaaggcttcaaac	11	11	13	6	0	3	1	2	0	1	1	3	4	3	4	0	5	2	3	0	5	3	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:45315483C>G	uc002xsk.2	-	2	894	c.671G>C	c.(670-672)AGC>ACC	p.S224T	SLC13A3_uc002xsg.1_5'Flank|SLC13A3_uc010gho.1_5'Flank|TP53RK_uc002xsj.2_3'UTR	NM_033550	NP_291028	Q96S44	PRPK_HUMAN	p53-related protein kinase	224	Protein kinase.				lipopolysaccharide biosynthetic process	membrane|nucleus	ATP binding|p53 binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Myeloproliferative disorder(115;0.0122)				GGTGGAGTAGCTCTTCAGAAA	0.488													44	80					0	0	0	0	G	45315483	G	G	45315483	3	3	98	1	0	0	0	0	1	0	0	0	16457	797	28	4	94	4	TP53RK	20	45315483	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	9290798	45315483	17710037	148	18879											
PREX1	57580	broad.mit.edu	37	chr20	47266017	47266017	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgccatcatggagaccctgGccttggggatcaccctctgc	6	9	11	15	0	3	1	2	0	1	1	3	3	3	2	4	4	2	0	4	4	0	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:47266017G>A	uc002xtw.1	-	25	3149	c.3126C>T	c.(3124-3126)GGC>GGT	p.G1042G	PREX1_uc002xtv.1_Silent_p.G339G	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1042					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GGAGACCCTGGCCTTGGGGAT	0.627													20	31					0	0	0	0	A	47266017	A	A	47266017	2	1	98	1	0	0	0	0	0	0	0	1	12538	1190	42	4		4	PREX1	20	47266017	Silent	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	1950534	47266017	15759503	149	18880											
CDH4	1002	broad.mit.edu	37	chr20	60485513	60485513	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgaaaaccgcgtggagacCgtggtcgcaaacctcacggt	10	5	12	14	6	1	1	1	0	0	1	2	3	1	1	4	3	2	1	4	3	3	0	rs148334531		TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:60485513C>T	uc002ybn.1	+	9	1238	c.1224C>T	c.(1222-1224)ACC>ACT	p.T408T	CDH4_uc002ybp.1_Silent_p.T334T	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	408	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GCGTGGAGACCGTGGTCGCAA	0.478													18	15					0	0	0	0	T	60485513	T	T	60485513	2	4	98	1	0	0	0	0	0	0	0	1	3127	639	23	1		1	CDH4	20	60485513	Silent	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	13219496	60485513	2540007	150	18881											
NPBWR2	2832	broad.mit.edu	37	chr20	62737451	62737451	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctagagccttggctccagagCggagccgcacggcccgcagc	7	4	14	16	4	0	2	0	0	0	2	1	3	1	3	4	3	4	3	4	3	1	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr20:62737451C>T	uc011abt.1	-	1	734	c.734G>A	c.(733-735)CGC>CAC	p.R245H		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	245	Cytoplasmic (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					GGCTCCAGAGCGGAGCCGCAC	0.667													9	13					0	0	0	0	T	62737451	T	T	62737451	3	4	98	1	0	0	0	0	1	0	0	0	10623	768	27	1	270	1	NPBWR2	20	62737451	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	2251938	62737451	288069	151	18882											
DIP2A	23181	broad.mit.edu	37	chr21	47971553	47971553	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcccccgtttctagaggttgGaccagcctcaatgatcgtgg	7	11	11	12	2	2	2	1	1	1	1	4	3	3	3	4	3	1	2	4	3	2	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr21:47971553G>T	uc002zjo.2	+	24	3029	c.2846G>T	c.(2845-2847)GGA>GTA	p.G949V	DIP2A_uc011afy.1_Missense_Mutation_p.G885V|DIP2A_uc011afz.1_Missense_Mutation_p.G945V	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	949					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CTAGAGGTTGGACCAGCCTCA	0.478													13	7					9.05144e-12	9.76981e-12	1	0	T	47971553	T	T	47971553	3	4	98	1	0	0	0	0	1	0	0	0	4549	1174	41	2	3022	2	DIP2A	21	47971553	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08		47971553	158342	152	18883											
PLXNB2	23654	broad.mit.edu	37	chr22	50728272	50728272	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtcttctctgcacatgcGtgccagcagcgtgcggttcc	4	10	14	13	3	2	0	0	0	2	0	4	0	3	0	2	3	6	3	2	3	0	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chr22:50728272G>A	uc003bkv.3	-	3	848	c.742C>T	c.(742-744)CGC>TGC	p.R248C		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	248	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTGCACATGCGTGCCAGCAGC	0.637													39	42					0	0	0	0	A	50728272	A	A	50728272	3	1	98	1	0	0	0	0	1	0	0	0	12179	1145	40	1	4914	1	PLXNB2	22	50728272	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08		50728272	576294	153	18884											
FAM47C	442444	broad.mit.edu	37	chrX	37028771	37028771	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactcgcgtatctcatctccGcccggagcctcctgagactg	6	9	10	16	4	2	1	1	1	2	1	6	4	3	2	4	1	1	1	4	1	1	1			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:37028771G>A	uc004ddl.1	+	1	2302	c.2288G>A	c.(2287-2289)CGC>CAC	p.R763H		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	763										ovary(3)	3						TCTCATCTCCGCCCGGAGCCT	0.627													15	8					0	0	0	0	A	37028771	A	A	37028771	3	1	98	1	0	0	0	0	1	0	0	0	5603	1087	38	1	2290	1	FAM47C	23	37028771	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08		37028771	118241789	154	18885											
CCNB3	85417	broad.mit.edu	37	chrX	50053854	50053854	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagaccatcttcaaggagtcTttggacttgcaagagaagcc	12	9	11	9	0	3	2	1	0	2	2	3	6	3	4	2	2	2	1	2	2	3	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:50053854T>G	uc004dox.3	+	6	2983	c.2685T>G	c.(2683-2685)TCT>TCG	p.S895S	CCNB3_uc004doy.2_Silent_p.S895S|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	895					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TCAAGGAGTCTTTGGACTTGC	0.502													7	8					0	0	0	0	G	50053854	G	G	50053854	2	3	98	1	0	0	0	0	0	0	0	1	2929	1596	56	5		5	CCNB3	23	50053854	Silent	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	13025083	50053854	105216706	155	18886											
DGKK	139189	broad.mit.edu	37	chrX	50121103	50121103	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttcccccttacccgatcTcttgtcagcatctgggcagc	6	13	7	15	1	3	0	1	0	2	0	5	1	4	0	3	1	3	2	3	1	1	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:50121103T>A	uc010njr.1	-	23	3165	c.3105A>T	c.(3103-3105)AGA>AGT	p.R1035S		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	1035					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TTACCCGATCTCTTGTCAGCA	0.453													20	16					0	0	0	0	A	50121103	A	A	50121103	3	1	98	1	0	0	0	0	1	0	0	0	4494	1551	54	5	738	5	DGKK	23	50121103	Missense_Mutation	SNP	T	TCGA-CQ-5332-01A-01D-1683-08	67249	50121103	105149457	156	18887											
HUWE1	10075	broad.mit.edu	37	chrX	53622348	53622348	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atagctcagcaagtgctcggCctaatctggaggaagctgaa	12	8	12	9	1	2	1	1	1	1	0	3	3	2	3	1	3	4	4	1	3	5	2			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:53622348C>T	uc004dsp.2	-	30	3581	c.3179G>A	c.(3178-3180)GGC>GAC	p.G1060D	HUWE1_uc004dsn.2_5'Flank	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1060					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AAGTGCTCGGCCTAATCTGGA	0.423													12	2					0	0	0	0	T	53622348	T	T	53622348	3	4	98	1	0	0	0	0	1	0	0	0	7500	739	26	4	10165	4	HUWE1	23	53622348	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	3501245	53622348	101648212	157	18888											
MAGED2	10916	broad.mit.edu	37	chrX	54836452	54836452	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aacagaatgctgacccgcagGctgtgacaatgcctgccact	11	7	10	13	1	0	3	0	2	0	1	0	3	0	3	3	1	4	3	3	1	3	0			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:54836452G>C	uc004dtk.1	+	3	437	c.343G>C	c.(343-345)GCT>CCT	p.A115P	MAGED2_uc004dtl.1_Missense_Mutation_p.A115P|MAGED2_uc004dtm.1_Missense_Mutation_p.A77P|MAGED2_uc010nkc.1_Missense_Mutation_p.A115P|MAGED2_uc004dtn.1_Missense_Mutation_p.A115P|MAGED2_uc004dto.1_Missense_Mutation_p.A89P	NM_177433	NP_803182	Q9UNF1	MAGD2_HUMAN	melanoma antigen family D, 2	115										ovary(2)|breast(1)	3						TGACCCGCAGGCTGTGACAAT	0.527													3	13					0	0	0	0	C	54836452	C	C	54836452	3	2	98	1	0	0	0	0	1	0	0	0	9237	1203	42	4	349	4	MAGED2	23	54836452	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	1214104	54836452	100434108	158	18889											
KIAA2022	340533	broad.mit.edu	37	chrX	73962753	73962753	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttcttctcacctttaaagcGattaatgatgatatatttga	12	17	6	6	1	2	3	1	3	2	0	3	4	2	3	1	0	1	1	1	0	5	8			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:73962753G>A	uc004eby.2	-	3	2256	c.1639C>T	c.(1639-1641)CGC>TGC	p.R547C		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	547					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CCTTTAAAGCGATTAATGATG	0.403													29	22					0	0	0	0	A	73962753	A	A	73962753	3	1	98	1	0	0	0	0	1	0	0	0	8308	1058	37	1	2919	1	KIAA2022	23	73962753	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	19126301	73962753	81307807	159	18890											
CXorf57	55086	broad.mit.edu	37	chrX	105881011	105881011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcatagaggccagccgtataCgtatgatgccaaggtaaaaa	15	8	10	8	2	1	2	1	1	0	1	1	2	1	2	3	2	3	3	3	2	8	5			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:105881011C>T	uc004emi.3	+	8	1581	c.1430C>T	c.(1429-1431)ACG>ATG	p.T477M	CXorf57_uc004emj.3_Missense_Mutation_p.T477M|CXorf57_uc004emh.2_Missense_Mutation_p.T477M	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	477								p.T477M(1)		ovary(1)|lung(1)|breast(1)	3						CAGCCGTATACGTATGATGCC	0.373													4	47					0	0	0	0	T	105881011	T	T	105881011	3	4	98	1	0	0	0	0	1	0	0	0	4130	536	19	1	1460	1	CXorf57	23	105881011	Missense_Mutation	SNP	C	TCGA-CQ-5332-01A-01D-1683-08	31918258	105881011	49389549	160	18891											
RGAG1	57529	broad.mit.edu	37	chrX	109694160	109694160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactttccccattgctaatGccagcctcagactctggggc	7	10	9	15	0	2	1	1	0	1	1	3	1	3	1	4	2	3	2	4	2	1	3			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:109694160G>A	uc004eor.1	+	3	561	c.315G>A	c.(313-315)ATG>ATA	p.M105I	RGAG1_uc011msr.1_Missense_Mutation_p.M105I	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	105										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CATTGCTAATGCCAGCCTCAG	0.527													89	44					0	0	0	0	A	109694160	A	A	109694160	3	1	98	1	0	0	0	0	1	0	0	0	13339	1319	46	4	317	4	RGAG1	23	109694160	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	3813149	109694160	45576400	161	18892											
DDX26B	203522	broad.mit.edu	37	chrX	134714085	134714085	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaagttcgaaagtttggtcGaagtaagtagtgaaagaaca	16	9	13	3	2	0	2	0	1	0	1	2	5	0	3	0	2	1	4	0	2	7	4			TCGA-CQ-5332-01A-01D-1683-08	TCGA-CQ-5332-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fdf4f0d-0a55-4b5e-8545-65f1aad37c10	55e19ee2-02cb-4f91-9108-1a71faad685d	g.chrX:134714085G>A	uc004eyw.3	+	15	2744	c.2381G>A	c.(2380-2382)CGA>CAA	p.R794Q	DDX26B_uc004eyx.3_Missense_Mutation_p.R395Q	NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	794											0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGTTTGGTCGAAGTAAGTAG	0.388													6	37					0	0	0	0	A	134714085	A	A	134714085	3	1	98	1	0	0	0	0	1	0	0	0	4370	1058	37	1	2439	1	DDX26B	23	134714085	Missense_Mutation	SNP	G	TCGA-CQ-5332-01A-01D-1683-08	25019925	134714085	20556475	162	18893											
CLCNKA	1187	broad.mit.edu	37	chr1	16359745	16359745	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctgtgggctgcgtgtcctgGgtggaggtaccagggtcccg	3	9	19	10	2	0	0	0	0	0	0	2	1	2	1	3	5	2	3	3	5	1	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:16359745G>C	uc001axu.2	+	19	2090	c.2010G>C	c.(2008-2010)TGG>TGC	p.W670C	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.W669C|CLCNKA_uc010obw.1_Missense_Mutation_p.W627C|CLCNKB_uc001axw.3_Intron	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	670	CBS 2.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	GCGTGTCCTGGGTGGAGGTAC	0.617											OREG0013132	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	136					0	0	0	0	C	16359745	C	C	16359745	3	2	99	1	0	0	0	0	1	0	0	0	3484	1241	43	4	2080	4	CLCNKA	1	16359745	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08		16359745	232890876	1	18894											
EPHA2	1969	broad.mit.edu	37	chr1	16464347	16464347	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgccacccctggacctcaCctgtctggttgatgctgaca	6	10	10	15	0	2	2	1	2	1	0	2	3	2	3	5	2	2	3	5	2	0	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:16464347C>A	uc001aya.1	-	5	1449	c.1312_splice	c.e5+1	p.E438_splice	EPHA2_uc010oca.1_Splice_Site_p.E438_splice	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor						activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CTGGACCTCACCTGTCTGGTT	0.607													25	35					0.00106085	0.00110347	1	0	A	16464347	A	A	16464347	5	1	99	1	0	0	0	0	0	0	1	0	5191	521	18	4	1669	4	EPHA2	1	16464347	Splice_Site	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	104602	16464347	232786274	2	18895											
PADI4	23569	broad.mit.edu	37	chr1	17674531	17674531	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcctgaaggagtttcccatCaaacgcgtgatggtacctgc	9	9	12	11	2	1	2	1	2	0	0	2	3	2	3	3	3	3	2	3	3	3	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:17674531C>G	uc001baj.2	+	10	1171	c.1143C>G	c.(1141-1143)ATC>ATG	p.I381M	PADI4_uc009vpc.2_Missense_Mutation_p.I381M	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	381					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	AGTTTCCCATCAAACGCGTGA	0.587													7	23					0	0	0	0	G	17674531	G	G	17674531	3	3	99	1	0	0	0	0	1	0	0	0	11434	816	29	2	1181	2	PADI4	1	17674531	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	1210184	17674531	231576090	3	18896											
HMGN2	3151	broad.mit.edu	37	chr1	26801616	26801616	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttttaggcacagaaagctGaaggtgctggagatgccaag	12	9	13	7	0	1	3	0	1	1	2	1	4	1	3	1	3	3	3	1	3	4	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:26801616G>A	uc001bmp.3	+	6	452	c.250G>A	c.(250-252)GAA>AAA	p.E84K	HMGN2_uc009vsk.2_Missense_Mutation_p.E69K|HMGN2_uc001bmq.3_Silent_p.L117L	NM_005517	NP_005508	P05204	HMGN2_HUMAN	high-mobility group nucleosomal binding domain	84					chromatin organization|regulation of transcription, DNA-dependent	chromatin|cytoplasm|nucleus	DNA binding|protein binding				0		all_cancers(24;1.9e-24)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.38e-49)|OV - Ovarian serous cystadenocarcinoma(117;5.38e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.026)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		ACAGAAAGCTGAAGGTGCTGG	0.368													14	66					0	0	0	0	A	26801616	A	A	26801616	3	1	99	1	0	0	0	0	1	0	0	0	7274	1291	45	2	272	2	HMGN2	1	26801616	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	9127085	26801616	222449005	4	18897											
CSMD2	114784	broad.mit.edu	37	chr1	34003072	34003072	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgccactccatgtcccatCtgactggcaaaacctgcgtg	8	9	10	14	1	1	1	0	1	1	0	3	1	3	1	4	2	3	1	4	2	2	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:34003072C>G	uc001bxn.1	-	60	9366	c.9337G>C	c.(9337-9339)GAT>CAT	p.D3113H	CSMD2_uc001bxm.1_Missense_Mutation_p.D3257H	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3113	Extracellular (Potential).|Sushi 24.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CATGTCCCATCTGACTGGCAA	0.607													15	110					0	0	0	0	G	34003072	G	G	34003072	3	3	99	1	0	0	0	0	1	0	0	0	3962	913	32	2	1166	2	CSMD2	1	34003072	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	7201456	34003072	215247549	5	18898											
EPHA10	284656	broad.mit.edu	37	chr1	38227248	38227248	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtgtggagaaggcgctctCggctgcggtggctgggaacg	6	7	19	9	4	1	1	0	0	1	1	2	3	1	2	0	6	2	3	0	6	2	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:38227248C>T	uc009vvi.2	-	3	765	c.679G>A	c.(679-681)GAG>AAG	p.E227K	EPHA10_uc001cbw.3_Missense_Mutation_p.E227K	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	227	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AAGGCGCTCTCGGCTGCGGTG	0.716													9	10					0	0	0	0	T	38227248	T	T	38227248	3	4	99	1	0	0	0	0	1	0	0	0	5190	893	31	1	2445	1	EPHA10	1	38227248	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	4224176	38227248	211023373	6	18899											
TMEM59	9528	broad.mit.edu	37	chr1	54513022	54513022	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaaacagcctgcaacctctCtgacatgcgtacaactcctc	12	8	6	15	1	1	1	0	1	1	0	4	2	2	1	3	0	7	2	3	0	5	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:54513022C>G	uc001cwp.2	-	2	463	c.213G>C	c.(211-213)CAG>CAC	p.Q71H	TMEM59_uc001cwo.2_5'UTR|TMEM59_uc001cwq.2_Missense_Mutation_p.Q71H|TMEM59_uc001cwr.2_Intron|TMEM59_uc001cws.1_Missense_Mutation_p.Q82H	NM_004872	NP_004863	Q9BXS4	TMM59_HUMAN	thymic dendritic cell-derived factor 1	71	Extracellular (Potential).					Golgi membrane|integral to membrane					0						TGCAACCTCTCTGACATGCGT	0.388													11	54					0	0	0	0	G	54513022	G	G	54513022	3	3	99	1	0	0	0	0	1	0	0	0	16251	912	32	2	786	2	TMEM59	1	54513022	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	16285774	54513022	194737599	7	18900											
EFCAB7	84455	broad.mit.edu	37	chr1	64034060	64034060	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccatatggaggcatgtagtgGacaacttgagaaggccattt	12	10	12	7	0	0	1	0	1	0	1	0	4	0	3	2	4	1	2	2	4	4	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:64034060G>T	uc001dbf.2	+	12	1871	c.1577G>T	c.(1576-1578)GGA>GTA	p.G526V		NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	526							calcium ion binding				0						GCATGTAGTGGACAACTTGAG	0.368													11	31					6.42651e-13	7.26882e-13	1	0	T	64034060	T	T	64034060	3	4	99	1	0	0	0	0	1	0	0	0	4962	1174	41	2	1619	2	EFCAB7	1	64034060	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	9521038	64034060	185216561	8	18901											
DIRAS3	9077	broad.mit.edu	37	chr1	68512777	68512777	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtaggtattttcaatggtCggcaggtactcatgacggaa	11	11	12	7	2	2	1	2	1	0	0	3	2	2	2	0	5	1	4	0	5	5	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:68512777C>T	uc001ded.2	-	2	499	c.204G>A	c.(202-204)CCG>CCA	p.P68P	uc001deb.1_Intron|uc001dec.1_Intron	NM_004675	NP_004666	O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	68	Effector region (Potential).				regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						TTTCAATGGTCGGCAGGTACT	0.597													25	73					0	0	0	0	T	68512777	T	T	68512777	2	4	99	1	0	0	0	0	0	0	0	1	4554	871	31	1		1	DIRAS3	1	68512777	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	4478717	68512777	180737844	9	18902											
DEPDC1	55635	broad.mit.edu	37	chr1	68948554	68948554	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtatcccactggatctatCtgaaactgtgatgtagccac	11	12	8	10	0	2	2	0	2	2	0	3	3	3	3	2	1	2	2	2	1	4	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:68948554C>G	uc001dem.3	-	8	1054	c.937G>C	c.(937-939)GAT>CAT	p.D313H	DEPDC1_uc001dej.3_5'Flank|DEPDC1_uc001dek.3_RNA|DEPDC1_uc001del.3_Intron	NM_001114120	NP_001107592	Q5TB30	DEP1A_HUMAN	DEP domain containing 1 isoform a	313	Rho-GAP.				intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		CTGGATCTATCTGAAACTGTG	0.328													13	66					0	0	0	0	G	68948554	G	G	68948554	3	3	99	1	0	0	0	0	1	0	0	0	4461	913	32	2	1518	2	DEPDC1	1	68948554	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	435777	68948554	180302067	10	18903											
AGL	178	broad.mit.edu	37	chr1	100387120	100387120	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggacttccagaactgacCaatgagaatgcccagtactg	15	7	9	10	0	0	3	0	2	0	2	1	5	1	4	3	1	3	1	3	1	5	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:100387120C>A	uc001dsi.1	+	34	4912	c.4512C>A	c.(4510-4512)ACC>ACA	p.T1504T	AGL_uc001dsj.1_Silent_p.T1504T|AGL_uc001dsk.1_Silent_p.T1504T|AGL_uc001dsl.1_Silent_p.T1504T|AGL_uc001dsm.1_Silent_p.T1488T|AGL_uc001dsn.1_Silent_p.T1487T	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1504	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CAGAACTGACCAATGAGAATG	0.353													3	56					0.00909568	0.00933609	1	0	A	100387120	A	A	100387120	2	1	99	1	0	0	0	0	0	0	0	1	384	581	21	4		4	AGL	1	100387120	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	31438566	100387120	148863501	11	18904											
PHGDH	26227	broad.mit.edu	37	chr1	120283058	120283059	+	Nonsense_Mutation	DNP	GG	AA	AA																															ctctccacacaccaagccttGgattggtctggcagaagctc																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:120283058_120283059GG>AA	uc001ehz.2	+	9	1222_1223	c.995_996GG>AA	c.(994-996)TGG>TAA	p.W332*	PHGDH_uc009whm.2_Nonsense_Mutation_p.W230*|PHGDH_uc001eia.2_Nonsense_Mutation_p.W331*|PHGDH_uc009whn.2_Nonsense_Mutation_p.W332*|PHGDH_uc001eib.2_Nonsense_Mutation_p.W298*|PHGDH_uc001eic.2_5'Flank	NM_006623	NP_006614	O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	332					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			ovary(1)	1	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	ACCAAGCCTTGGATTGGTCTGG	0.609													8	7					0	0	0	0	AA	120283059	AA	AA	120283058	4	1	99	1	0	0	0	0	0	1	0	0	11896	1357	47	4	1029	4	PHGDH	1	120283058	Nonsense_Mutation	DNP	GG	TCGA-CQ-5334-01A-01D-1683-08	19895938	120283058	128967563	12	18905											
BCL9	607	broad.mit.edu	37	chr1	147091006	147091006	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacactgggagagaatcccGatggcctatctcaggagcag	11	6	12	12	1	1	1	1	0	1	1	3	5	2	3	3	3	1	1	3	3	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:147091006G>A	uc001epq.2	+	8	1785	c.1045G>A	c.(1045-1047)GAT>AAT	p.D349N	BCL9_uc010ozr.1_Missense_Mutation_p.D275N	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	349	CTNNB1-binding.|Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					AGAGAATCCCGATGGCCTATC	0.577			T	IGH@|IGL@	B-ALL								15	76					0	0	0	0	A	147091006	A	A	147091006	3	1	99	1	0	0	0	0	1	0	0	0	1383	1058	37	1	1063	1	BCL9	1	147091006	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	26807948	147091006	102159615	13	18906											
THEM4	117145	broad.mit.edu	37	chr1	151861698	151861699	+	Frame_Shift_Ins	INS	-	C	C																															atcattcttacccaggtggtINSccttccaggtaagggcctcc																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:151861698_151861699insC	uc001ezj.1	-	3	616_617	c.437_438insG	c.(436-438)GGAfs	p.G146fs	THEM4_uc001ezk.1_RNA	NM_053055	NP_444283	Q5T1C6	THEM4_HUMAN	thioesterase superfamily member 4	146					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|ruffle membrane					0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACCCAGGTGGTCCTTCCAGGTA	0.416													---	---	---								C	151861699	C	C	151861698	7	5	99	1	0	1	1	0	0	0	0	0	15924	1654	58	0	300	0	THEM4	1	151861698	Frame_Shift_Ins	INS	-	TCGA-CQ-5334-01A-01D-1683-08	4770692	151861698	97388923	14	18907											
SPRR2B	6701	broad.mit.edu	37	chr1	153043109	153043109	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaagctgttacttgctcttCggtggatactttggctggca	6	15	12	8	1	1	1	0	1	1	0	2	2	1	2	0	4	4	5	0	4	3	5	rs143849195	byFrequency	TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:153043109C>T	uc001fbg.2	-	2	270	c.207G>A	c.(205-207)CCG>CCA	p.P69P	SPRR2D_uc009wnz.2_Intron|SPRR2A_uc001fbf.2_Intron|SPRR2A_uc009woa.2_Intron	NM_001017418	NP_001017418	P35325	SPR2B_HUMAN	small proline-rich protein 2B	69					keratinization	cornified envelope|cytoplasm					0	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACTTGCTCTTCGGTGGATACT	0.532													22	114					0	0	0	0	T	153043109	T	T	153043109	2	4	99	1	0	0	0	0	0	0	0	1	15164	871	31	1		1	SPRR2B	1	153043109	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	1181411	153043109	96207512	15	18908											
S100A3	6274	broad.mit.edu	37	chr1	153520180	153520180	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgggagcaggggggctctGaggggcagtccttgaagtac	8	7	18	8	0	1	2	0	2	1	0	2	3	2	3	1	6	2	4	1	6	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:153520180G>C	uc001fca.1	-	3	367	c.284C>G	c.(283-285)TCA>TGA	p.S95*	S100A4_uc001fby.2_5'Flank|S100A4_uc001fbz.2_5'Flank|uc009wog.1_Intron	NM_002960	NP_002951	P33764	S10A3_HUMAN	S100 calcium binding protein A3	95							calcium ion binding|protein binding				0	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGGGGCTCTGAGGGGCAGTC	0.627													20	84					0	0	0	0	C	153520180	C	C	153520180	4	2	99	1	0	0	0	0	0	1	0	0	13844	1294	45	2	25	2	S100A3	1	153520180	Nonsense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	477071	153520180	95730441	16	18909											
S100A3	6274	broad.mit.edu	37	chr1	153520231	153520231	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagacagaggcaggcaagtGagcgcacatactccacaaag	16	3	12	10	1	0	3	0	1	0	2	1	4	1	3	1	2	2	3	1	2	3	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:153520231G>C	uc001fca.1	-	3	316	c.233C>G	c.(232-234)TCA>TGA	p.S78*	S100A4_uc001fby.2_5'Flank|S100A4_uc001fbz.2_5'Flank|uc009wog.1_Intron	NM_002960	NP_002951	P33764	S10A3_HUMAN	S100 calcium binding protein A3	78	EF-hand 2.						calcium ion binding|protein binding				0	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAGGCAAGTGAGCGCACATA	0.562													23	102					0	0	0	0	C	153520231	C	C	153520231	4	2	99	1	0	0	0	0	0	1	0	0	13844	1294	45	2	76	2	S100A3	1	153520231	Nonsense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	51	153520231	95730390	17	18910											
CD1E	913	broad.mit.edu	37	chr1	158325689	158325689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagcttgtgtgccatgtctCaggattctacccaaagcccg	8	10	10	13	1	2	0	1	0	2	0	3	1	2	1	3	1	4	2	3	1	2	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:158325689C>T	uc001fse.2	+	4	937	c.698C>T	c.(697-699)TCA>TTA	p.S233L	CD1E_uc010pid.1_Missense_Mutation_p.S231L|CD1E_uc010pie.1_Missense_Mutation_p.S134L|CD1E_uc010pif.1_Missense_Mutation_p.S44L|CD1E_uc001fsd.2_Missense_Mutation_p.S233L|CD1E_uc001fsk.2_Missense_Mutation_p.S143L|CD1E_uc001fsj.2_Missense_Mutation_p.S143L|CD1E_uc001fsc.2_Missense_Mutation_p.S44L|CD1E_uc010pig.1_RNA|CD1E_uc001fsa.2_Missense_Mutation_p.S44L|CD1E_uc001fsf.2_Missense_Mutation_p.S233L|CD1E_uc001fry.2_Missense_Mutation_p.S233L|CD1E_uc001fsg.2_Missense_Mutation_p.S44L|CD1E_uc001fsh.2_Missense_Mutation_p.S44L|CD1E_uc001fsi.2_Missense_Mutation_p.S233L|CD1E_uc009wsv.2_Missense_Mutation_p.S134L|CD1E_uc001frz.2_Missense_Mutation_p.S143L|CD1E_uc009wsw.2_5'UTR	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	233	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					TGCCATGTCTCAGGATTCTAC	0.587													7	55					0	0	0	0	T	158325689	T	T	158325689	3	4	99	1	0	0	0	0	1	0	0	0	2993	838	29	2	712	2	CD1E	1	158325689	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	4805458	158325689	90924932	18	18911											
IGSF8	93185	broad.mit.edu	37	chr1	160063016	160063016	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacagagtatgcagcatgaCggcctgctgggggaagtgcc	9	7	15	10	1	0	2	0	1	0	1	0	3	0	3	2	3	5	4	2	3	3	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:160063016C>T	uc001fva.2	-	4	1055	c.1010G>A	c.(1009-1011)CGT>CAT	p.R337H	IGSF8_uc001fuz.2_Missense_Mutation_p.R337H|IGSF8_uc009wtf.2_Missense_Mutation_p.R337H	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	337	Ig-like C2-type 3.|Extracellular (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGCAGCATGACGGCCTGCTGG	0.667													8	25					0	0	0	0	T	160063016	T	T	160063016	3	4	99	1	0	0	0	0	1	0	0	0	7643	536	19	1	843	1	IGSF8	1	160063016	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	1737327	160063016	89187605	19	18912											
VANGL2	57216	broad.mit.edu	37	chr1	160389273	160389273	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgccgtgtcgctggtggacgCccttcttttcgtgcactacc	3	12	11	15	5	1	0	0	0	1	0	3	1	1	1	3	2	2	2	3	2	1	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:160389273C>A	uc001fwb.1	+	5	973	c.674C>A	c.(673-675)GCC>GAC	p.A225D	VANGL2_uc001fwc.1_Missense_Mutation_p.A225D	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	225	Helical; Name=4; (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTGGTGGACGCCCTTCTTTTC	0.652													17	67					4.96729e-08	5.35823e-08	1	0	A	160389273	A	A	160389273	3	1	99	1	0	0	0	0	1	0	0	0	17188	739	26	4	684	4	VANGL2	1	160389273	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	326257	160389273	88861348	20	18913											
LY9	4063	broad.mit.edu	37	chr1	160793987	160793987	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagggaaagaccccagtttCtcagaaggaagagagctcag	15	5	12	9	0	2	3	2	0	1	3	3	6	2	5	2	2	1	2	2	2	3	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:160793987C>G	uc001fwu.2	+	9	1897	c.1847C>G	c.(1846-1848)TCT>TGT	p.S616C	LY9_uc001fwv.2_Missense_Mutation_p.S602C|LY9_uc001fww.2_Missense_Mutation_p.S526C|LY9_uc001fwx.2_Intron|LY9_uc001fwz.2_Intron	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	616	Cytoplasmic (Potential).				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ACCCCAGTTTCTCAGAAGGAA	0.498													33	100					0	0	0	0	G	160793987	G	G	160793987	3	3	99	1	0	0	0	0	1	0	0	0	9152	913	32	2	2013	2	LY9	1	160793987	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	404714	160793987	88456634	21	18914											
LAMC1	3915	broad.mit.edu	37	chr1	183086470	183086470	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagatgaggatgggtggcGtgcggaacagagagatggct	10	7	19	5	2	0	4	0	1	0	3	0	7	0	6	0	5	3	2	0	5	1	0	rs148393996	byFrequency	TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:183086470G>A	uc001gpy.3	+	9	1837	c.1580G>A	c.(1579-1581)CGT>CAT	p.R527H		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	527	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GATGGGTGGCGTGCGGAACAG	0.463													3	27					0	0	0	0	A	183086470	A	A	183086470	3	1	99	1	0	0	0	0	1	0	0	0	8654	1145	40	1	1614	1	LAMC1	1	183086470	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	22292483	183086470	66164151	22	18915											
CENPF	1063	broad.mit.edu	37	chr1	214818774	214818774	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgccttgaagaagaactctCagtggtcacaagtgagagaa	14	8	11	8	0	2	5	2	2	1	3	3	6	2	5	1	1	2	0	1	1	5	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:214818774C>T	uc001hkm.2	+	13	6035	c.5861C>T	c.(5860-5862)TCA>TTA	p.S1954L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2050	Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GAAGAACTCTCAGTGGTCACA	0.393													13	51					0	0	0	0	T	214818774	T	T	214818774	3	4	99	1	0	0	0	0	1	0	0	0	3246	838	29	2	5907	2	CENPF	1	214818774	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	31732304	214818774	34431847	23	18916											
OR2L13	284521	broad.mit.edu	37	chr1	248263205	248263205	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctagggctattgaccatttCttctgcgatgtcccagccat	7	14	8	12	1	3	1	0	1	3	0	4	2	4	1	3	1	2	1	3	1	2	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr1:248263205C>A	uc001ids.2	+	3	865	c.528C>A	c.(526-528)TTC>TTA	p.F176L		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TTGACCATTTCTTCTGCGATG	0.463													26	135					4.7796e-09	5.25305e-09	1	0	A	248263205	A	A	248263205	3	1	99	1	0	0	0	0	1	0	0	0	11060	912	32	2	530	2	OR2L13	1	248263205	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	33444431	248263205	987416	24	18917											
HADHB	3032	broad.mit.edu	37	chr2	26502944	26502945	+	Missense_Mutation	DNP	GC	TA	TA																															ctaaaacctgcattcatcaaGccctacggcacagtgacagc																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:26502944_26502945GC>TA	uc002rgz.2	+	10	1145_1146	c.894_895GC>TA	c.(892-897)AAGCCC>AATACC	p.298_299KP>NT	HADHB_uc010ykv.1_Missense_Mutation_p.276_277KP>NT|HADHB_uc010ykw.1_Missense_Mutation_p.283_284KP>NT|HADHB_uc002rha.2_Missense_Mutation_p.175_176KP>NT|HADHB_uc010ykx.1_Missense_Mutation_p.224_225KP>NT	NM_000183	NP_000174	P55084	ECHB_HUMAN	mitochondrial trifunctional protein, beta	298_299					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATTCATCAAGCCCTACGGCAC	0.371													18	82					0	0	0	0	TA	26502945	TA	TA	26502944	3	4	99	1	0	0	0	0	1	0	0	0	6983	962	34	4	928	4	HADHB	2	26502944	Missense_Mutation	DNP	GC	TCGA-CQ-5334-01A-01D-1683-08		26502944	216696429	25	18918											
FOSL2	2355	broad.mit.edu	37	chr2	28634936	28634949	+	Frame_Shift_Del	DEL	CCCCAGCCCCTGGG	-	-																															ccccgaggagcgccgatcgcCcccagcccctgggctgcagc																								rs112106981		TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:28634936_28634949delCCCCAGCCCCTGGG	uc002rma.2	+	4	1411_1424	c.602_615delCCCCAGCCCCTGGG	c.(601-615)CCCCCAGCCCCTGGGfs	p.P201fs	FOSL2_uc010ymi.1_Frame_Shift_Del_p.P162fs	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	201_205					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					CGCCGATCGCCCCCAGCCCCTGGGCTGCAGCCCA	0.654													---	---	---								-	28634949	-	-	28634936	7	5	99	1	0	1	0	1	0	0	0	0	6020	623	22	0	616	0	FOSL2	2	28634936	Frame_Shift_Del	DEL	CCCCAGCCCCTGGG	TCGA-CQ-5334-01A-01D-1683-08	2131992	28634936	214564437	26	18919											
SMEK2	57223	broad.mit.edu	37	chr2	55825607	55825607	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaataaaagacgtaagagtaGaaagaaaattctcttcaaaa	23	8	6	4	1	2	4	1	0	1	4	3	4	2	4	0	0	0	2	0	0	10	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:55825607G>A	uc002rzc.2	-	4	1241	c.866C>T	c.(865-867)TCT>TTT	p.S289F	SMEK2_uc002rzb.2_Missense_Mutation_p.S289F|SMEK2_uc002rzd.2_Missense_Mutation_p.S289F|SMEK2_uc002rza.2_Missense_Mutation_p.S165F	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	289						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CGTAAGAGTAGAAAGAAAATT	0.343													9	37					0	0	0	0	A	55825607	A	A	55825607	3	1	99	1	0	0	0	0	1	0	0	0	14858	942	33	2	1739	2	SMEK2	2	55825607	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	27190671	55825607	187373766	27	18920											
LOXL3	84695	broad.mit.edu	37	chr2	74763429	74763429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccacctcaccctgccccatgCgagcgccactcagagcttct	7	7	7	20	2	3	1	2	0	1	1	3	2	3	1	6	0	4	1	6	0	0	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:74763429C>T	uc002smp.1	-	6	1154	c.1082G>A	c.(1081-1083)CGC>CAC	p.R361H	LOXL3_uc002smo.1_5'UTR|LOXL3_uc010ffm.1_Missense_Mutation_p.R361H|LOXL3_uc002smq.1_Missense_Mutation_p.R216H|LOXL3_uc010ffn.1_Missense_Mutation_p.R216H	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	361	SRCR 3.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						CTGCCCCATGCGAGCGCCACT	0.642													33	130					0	0	0	0	T	74763429	T	T	74763429	3	4	99	1	0	0	0	0	1	0	0	0	8951	768	27	1	1215	1	LOXL3	2	74763429	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	18937822	74763429	168435944	28	18921											
TMEM131	23505	broad.mit.edu	37	chr2	98430838	98430838	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaataatgttgcagcatgatCaaatcccaaataactattaa	19	11	4	7	0	1	1	1	1	0	0	2	1	2	1	1	0	3	3	1	0	7	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:98430838C>G	uc002syh.3	-	14	1535	c.1306G>C	c.(1306-1308)GAT>CAT	p.D436H	TMEM131_uc010yvg.1_RNA	NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	436						integral to membrane				ovary(4)|central_nervous_system(2)	6						GCAGCATGATCAAATCCCAAA	0.323													5	22					0	0	0	0	G	98430838	G	G	98430838	3	3	99	1	0	0	0	0	1	0	0	0	16110	826	29	2	4457	2	TMEM131	2	98430838	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	23667409	98430838	144768535	29	18922											
RPL31	6160	broad.mit.edu	37	chr2	101622470	101622470	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtccagaaaacgtaatgagGatgaagattcaccaaataag	18	8	9	6	1	1	4	1	2	0	2	2	5	2	5	2	1	1	1	2	1	6	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:101622470G>A	uc002taq.3	+	4	370	c.283G>A	c.(283-285)GAT>AAT	p.D95N	RPL31_uc002tar.3_Missense_Mutation_p.D95N|RPL31_uc010yvu.1_Missense_Mutation_p.D95N|RPL31_uc010yvv.1_Missense_Mutation_p.D95N|RPL31_uc010fiu.1_Missense_Mutation_p.D95N|RPL31_uc002tas.1_Missense_Mutation_p.D95N|RPL31_uc002tat.1_3'UTR	NM_000993	NP_000984	P62899	RL31_HUMAN	ribosomal protein L31 isoform 1	95					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						ACGTAATGAGGATGAAGATTC	0.378													8	30					0	0	0	0	A	101622470	A	A	101622470	3	1	99	1	0	0	0	0	1	0	0	0	13646	1174	41	2	293	2	RPL31	2	101622470	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	3191632	101622470	141576903	30	18923											
ST6GAL2	84620	broad.mit.edu	37	chr2	107460350	107460350	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggttgctgtcggtgaagtaGatgaaaatcagcaaaaagag	15	8	14	4	1	1	4	1	2	0	2	2	4	1	4	0	2	2	4	0	2	6	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:107460350G>C	uc002tdq.2	-	2	203	c.84C>G	c.(82-84)ATC>ATG	p.I28M	ST6GAL2_uc002tdr.2_Missense_Mutation_p.I28M|ST6GAL2_uc002tds.3_Missense_Mutation_p.I28M	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	28	Helical; Signal-anchor for type II membrane protein; (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CGGTGAAGTAGATGAAAATCA	0.562													7	24					0	0	0	0	C	107460350	C	C	107460350	3	2	99	1	0	0	0	0	1	0	0	0	15288	932	33	2	1612	2	ST6GAL2	2	107460350	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	5837880	107460350	135739023	31	18924											
PCDP1	200373	broad.mit.edu	37	chr2	120373262	120373262	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaggtccagggcacaaaaaCggtttcaacaagtagcacgc	14	5	11	11	2	1	0	1	0	0	0	2	0	2	0	1	3	3	5	1	3	5	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:120373262C>T	uc002tmb.2	+	15	1621	c.529C>T	c.(529-531)CGG>TGG	p.R177W	PCDP1_uc010yyq.1_Missense_Mutation_p.R307W	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	463						cilium	calmodulin binding				0	Colorectal(110;0.196)					GGCACAAAAACGGTTTCAACA	0.388													3	24					0	0	0	0	T	120373262	T	T	120373262	3	4	99	1	0	0	0	0	1	0	0	0	11626	527	19	1	551	1	PCDP1	2	120373262	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	12912912	120373262	122826111	32	18925											
LRP1B	53353	broad.mit.edu	37	chr2	141115599	141115599	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgcagtcatcaagtcgatCacactggagatccataggga	12	8	10	11	2	3	1	3	0	0	1	6	4	5	2	2	2	0	1	2	2	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:141115599C>A	uc002tvj.1	-	74	12316	c.11344G>T	c.(11344-11346)GAT>TAT	p.D3782Y		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3782	Extracellular (Potential).|LDL-receptor class A 32.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCAAGTCGATCACACTGGAGA	0.413										TSP Lung(27;0.18)			21	56					3.5997e-14	4.11142e-14	1	0	A	141115599	A	A	141115599	3	1	99	1	0	0	0	0	1	0	0	0	9005	826	29	2	2527	2	LRP1B	2	141115599	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	20742337	141115599	102083774	33	18926											
ACVR1	90	broad.mit.edu	37	chr2	158595074	158595074	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaacggtggcttgtaatcctCcactatacctgcacacaagg	11	9	9	12	1	0	0	0	0	0	0	2	1	2	0	3	3	3	3	3	3	5	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:158595074C>G	uc002tzm.3	-	11	1612	c.1273G>C	c.(1273-1275)GAG>CAG	p.E425Q	ACVR1_uc002tzn.3_Missense_Mutation_p.E425Q|ACVR1_uc010fog.2_Missense_Mutation_p.E425Q	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	425	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	TTGTAATCCTCCACTATACCT	0.453													15	78					0	0	0	0	G	158595074	G	G	158595074	3	3	99	1	0	0	0	0	1	0	0	0	220	864	30	2	264	2	ACVR1	2	158595074	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	17479475	158595074	84604299	34	18927											
PLCL1	5334	broad.mit.edu	37	chr2	198949131	198949131	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggaaaaactaaccacccGcgtgaccgaagaggaatttt	16	6	9	10	3	0	2	0	1	0	1	0	5	0	4	3	2	2	0	3	2	6	3	rs140990771		TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:198949131G>A	uc010fsp.2	+	2	1181	c.890G>A	c.(889-891)CGC>CAC	p.R297H	PLCL1_uc002uuv.3_Missense_Mutation_p.R218H	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	297					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CTAACCACCCGCGTGACCGAA	0.373													19	73					0	0	0	0	A	198949131	A	A	198949131	3	1	99	1	0	0	0	0	1	0	0	0	12094	1087	38	1	896	1	PLCL1	2	198949131	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	40354057	198949131	44250242	35	18928											
FAM126B	285172	broad.mit.edu	37	chr2	201846381	201846381	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catactgcttgcgaactactGaatctcgagggctctcactg	9	11	9	12	2	2	1	1	1	2	0	4	3	2	1	0	1	5	2	0	1	4	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:201846381G>A	uc002uws.3	-	12	1393	c.1205C>T	c.(1204-1206)TCA>TTA	p.S402L	FAM126B_uc002uwu.2_Missense_Mutation_p.S376L|FAM126B_uc002uwv.2_Missense_Mutation_p.S402L	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	402						intracellular				ovary(1)	1						GCGAACTACTGAATCTCGAGG	0.488													5	33					0	0	0	0	A	201846381	A	A	201846381	3	1	99	1	0	0	0	0	1	0	0	0	5458	1294	45	2	391	2	FAM126B	2	201846381	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	2897250	201846381	41352992	36	18929											
FAM126B	285172	broad.mit.edu	37	chr2	201846438	201846438	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtttctttatccttggctGaacgcccagttgctactttc	5	17	7	12	1	1	1	0	1	1	0	3	1	2	1	2	1	3	4	2	1	3	7			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:201846438G>A	uc002uws.3	-	12	1336	c.1148C>T	c.(1147-1149)TCA>TTA	p.S383L	FAM126B_uc002uwu.2_Missense_Mutation_p.S357L|FAM126B_uc002uwv.2_Missense_Mutation_p.S383L	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	383						intracellular				ovary(1)	1						ATCCTTGGCTGAACGCCCAGT	0.493													7	34					0	0	0	0	A	201846438	A	A	201846438	3	1	99	1	0	0	0	0	1	0	0	0	5458	1294	45	2	448	2	FAM126B	2	201846438	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	57	201846438	41352935	37	18930											
CASP8	841	broad.mit.edu	37	chr2	202131210	202131210	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcctgccttttaaaaagAtggacttcagcagaaatctt	12	14	6	9	0	3	2	1	0	2	2	4	3	3	3	2	1	2	1	2	1	4	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:202131210A>G	uc002uxr.1	+	3	210	c.1A>G	c.(1-3)ATG>GTG	p.M1V	CASP8_uc010ftc.1_Missense_Mutation_p.M1V|CASP8_uc002uxo.1_Missense_Mutation_p.M1V|CASP8_uc002uxp.1_Missense_Mutation_p.M1V|CASP8_uc002uxq.1_Missense_Mutation_p.M1V|CASP8_uc002uxs.1_Missense_Mutation_p.M1V|CASP8_uc002uxt.1_Missense_Mutation_p.M60V|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.M1V|CASP8_uc002uxw.1_Missense_Mutation_p.M1V|CASP8_uc002uxy.1_Missense_Mutation_p.M1V|CASP8_uc002uxx.1_Missense_Mutation_p.M1V|CASP8_uc010ftf.2_Missense_Mutation_p.M1V	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	1					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TTTTAAAAAGATGGACTTCAG	0.398										HNSCC(4;0.00038)			8	28					0	0	0	0	G	202131210	G	G	202131210	3	3	99	1	0	0	0	0	1	0	0	0	2689	347	12	5	184	5	CASP8	2	202131210	Missense_Mutation	SNP	A	TCGA-CQ-5334-01A-01D-1683-08	284772	202131210	41068163	38	18931											
PIKFYVE	200576	broad.mit.edu	37	chr2	209194623	209194623	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acattaggaatatttttagaGagatactgtttcaggtaaga	15	14	9	3	0	1	3	1	0	0	3	1	5	1	4	0	2	1	2	0	2	6	8			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:209194623G>C	uc002vcz.2	+	22	3935	c.3777G>C	c.(3775-3777)GAG>GAC	p.E1259D	PIKFYVE_uc002vcy.1_Missense_Mutation_p.E1203D	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1259					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TATTTTTAGAGAGATACTGTT	0.318													7	28					0	0	0	0	C	209194623	C	C	209194623	3	2	99	1	0	0	0	0	1	0	0	0	11979	933	33	2	3870	2	PIKFYVE	2	209194623	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	7063413	209194623	34004750	39	18932											
SLC23A3	151295	broad.mit.edu	37	chr2	220029051	220029051	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactaagtgagccacttgctGagatccagcctgcatgaaga	12	8	10	11	0	0	4	0	3	0	2	1	5	1	4	3	0	4	2	3	0	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:220029051G>C	uc010zks.1	-	9	1288	c.1177C>G	c.(1177-1179)CAG>GAG	p.Q393E	NHEJ1_uc002vjq.3_Intron|SLC23A3_uc010zkr.1_Missense_Mutation_p.Q401E|SLC23A3_uc010fwb.2_Missense_Mutation_p.Q276E	NM_001144889	NP_001138361	Q6PIS1	S23A3_HUMAN	solute carrier family 23 (nucleobase	393	Cytoplasmic (Potential).				transmembrane transport	integral to membrane	protein binding|transporter activity				0		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCACTTGCTGAGATCCAGCC	0.438													2	7					0	0	0	0	C	220029051	C	C	220029051	3	2	99	1	0	0	0	0	1	0	0	0	14528	1299	45	2	671	2	SLC23A3	2	220029051	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	10834428	220029051	23170322	40	18933											
SPEG	10290	broad.mit.edu	37	chr2	220344508	220344508	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccactatttccacagatcCgggcctatatgcggcaggtg	8	9	11	13	2	0	1	0	0	0	1	2	1	2	1	4	3	1	1	4	3	3	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:220344508C>T	uc010fwg.2	+	24	5089	c.5089C>T	c.(5089-5091)CGG>TGG	p.R1697W		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1697	Protein kinase 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCCACAGATCCGGGCCTATAT	0.602													5	30					0	0	0	0	T	220344508	T	T	220344508	3	4	99	1	0	0	0	0	1	0	0	0	15102	643	23	1	5195	1	SPEG	2	220344508	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	315457	220344508	22854865	41	18934											
FARSB	10056	broad.mit.edu	37	chr2	223494891	223494891	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataatatcaagaactattttTgcctgcaaagaaaagaaaaa	21	10	5	5	0	1	3	1	0	0	3	1	3	1	3	1	0	3	1	1	0	10	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:223494891T>G	uc002vne.1	-	9	824	c.789A>C	c.(787-789)GCA>GCC	p.A263A	FARSB_uc010zlq.1_Silent_p.A283A|FARSB_uc002vnf.1_Silent_p.A164A	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	263					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	GAACTATTTTTGCCTGCAAAG	0.299													10	39					0	0	0	0	G	223494891	G	G	223494891	2	3	99	1	0	0	0	0	0	0	0	1	5712	1799	63	5		5	FARSB	2	223494891	Silent	SNP	T	TCGA-CQ-5334-01A-01D-1683-08	3150383	223494891	19704482	42	18935											
ARMC9	80210	broad.mit.edu	37	chr2	232081419	232081419	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaccaaaggggcagccttGagccagaccacagagtttct	12	6	12	11	0	1	4	0	1	1	3	1	5	1	4	4	2	2	2	4	2	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:232081419G>C	uc002vrq.3	+	5	529	c.417G>C	c.(415-417)TTG>TTC	p.L139F	ARMC9_uc002vrp.3_Missense_Mutation_p.L139F	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	139							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		GGGCAGCCTTGAGCCAGACCA	0.458													20	95					0	0	0	0	C	232081419	C	C	232081419	3	2	99	1	0	0	0	0	1	0	0	0	960	1281	45	2	431	2	ARMC9	2	232081419	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	8586528	232081419	11117954	43	18936											
AGAP1	116987	broad.mit.edu	37	chr2	236957775	236957775	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agggatccaccggaatcttgGcacccacctttcccgagtcc	8	8	9	16	2	1	0	0	0	1	0	4	3	4	2	6	3	0	1	6	3	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr2:236957775G>A	uc002vvs.2	+	16	2559	c.1964G>A	c.(1963-1965)GGC>GAC	p.G655D	AGAP1_uc002vvt.2_Missense_Mutation_p.G602D	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	655	Arf-GAP.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						CGGAATCTTGGCACCCACCTT	0.557													3	59					0	0	0	0	A	236957775	A	A	236957775	3	1	99	1	0	0	0	0	1	0	0	0	366	1203	42	4	2026	4	AGAP1	2	236957775	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	4876356	236957775	6241598	44	18937											
LZTFL1	54585	broad.mit.edu	37	chr3	45879466	45879466	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatctacagttttgagtctCaagcctctctttgaacgagc	10	13	8	10	1	3	2	1	2	3	0	5	4	3	2	1	0	4	1	1	0	4	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:45879466C>A	uc003cox.1	-	2	219	c.81G>T	c.(79-81)TTG>TTT	p.L27F	LZTFL1_uc003coy.1_Missense_Mutation_p.L10F|LZTFL1_uc011bak.1_Intron	NM_020347	NP_065080	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	27											0				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		TTTTGAGTCTCAAGCCTCTCT	0.403													6	51					0.00198382	0.00205435	1	0	A	45879466	A	A	45879466	3	1	99	1	0	0	0	0	1	0	0	0	9187	825	29	2	854	2	LZTFL1	3	45879466	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		45879466	152142964	45	18938											
PTH1R	5745	broad.mit.edu	37	chr3	46937282	46937282	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccacatcagggaagcccaGgaaagataaggcatctggga	14	5	13	9	0	2	1	1	0	1	1	3	4	3	4	2	4	1	1	2	4	3	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:46937282G>A	uc003cqm.2	+	5	439	c.236G>A	c.(235-237)AGG>AAG	p.R79K	PTH1R_uc003cqn.2_Missense_Mutation_p.R79K	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	79	Extracellular (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						GGGAAGCCCAGGAAAGATAAG	0.547									Ollier_disease_/_Maffuci_syndrome		OREG0015543	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	23					0	0	0	0	A	46937282	A	A	46937282	3	1	99	1	0	0	0	0	1	0	0	0	12821	1000	35	4	246	4	PTH1R	3	46937282	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	1057816	46937282	151085148	46	18939											
SCAP	22937	broad.mit.edu	37	chr3	47469138	47469138	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cacttgcagacacaactcctCcaagctcctgatcccagagc	11	7	6	17	0	0	3	0	1	0	2	4	3	4	3	4	0	4	2	4	0	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:47469138C>G	uc003crh.1	-	5	685	c.430G>C	c.(430-432)GAG>CAG	p.E144Q	SCAP_uc011baz.1_Intron|SCAP_uc003crg.2_Intron	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	144	Lumenal (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		CACAACTCCTCCAAGCTCCTG	0.587													8	25					0	0	0	0	G	47469138	G	G	47469138	3	3	99	1	0	0	0	0	1	0	0	0	13942	864	30	2	3485	2	SCAP	3	47469138	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	531856	47469138	150553292	47	18940											
CELSR3	1951	broad.mit.edu	37	chr3	48680426	48680426	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgctggccttgcctcctCaggcgctgccttcctgccca	3	10	11	17	1	1	0	1	0	0	0	3	0	3	0	6	3	4	2	6	3	0	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:48680426C>T	uc003cul.2	-	29	8661	c.8380G>A	c.(8380-8382)GAG>AAG	p.E2794K	CELSR3_uc003cuf.1_Missense_Mutation_p.E2892K|CELSR3_uc010hkf.2_Missense_Mutation_p.E84K|CELSR3_uc010hkg.2_Missense_Mutation_p.E777K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2794	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTTGCCTCCTCAGGCGCTGCC	0.627													19	64					0	0	0	0	T	48680426	T	T	48680426	3	4	99	1	0	0	0	0	1	0	0	0	3238	835	29	2	1586	2	CELSR3	3	48680426	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	1211288	48680426	149342004	48	18941											
GNAT1	2779	broad.mit.edu	37	chr3	50230738	50230738	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	actcgctggaagagtgcctcGagtttatcgccatcatctac	9	11	9	12	3	2	1	1	0	1	1	5	3	2	2	2	1	2	2	2	1	3	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:50230738G>C	uc003cym.2	+	3	306	c.190G>C	c.(190-192)GAG>CAG	p.E64Q	GNAT1_uc003cyl.2_Missense_Mutation_p.E64Q	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	64					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		AGAGTGCCTCGAGTTTATCGC	0.587											OREG0015579	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	50					0	0	0	0	C	50230738	C	C	50230738	3	2	99	1	0	0	0	0	1	0	0	0	6548	1059	37	3	200	3	GNAT1	3	50230738	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	1550312	50230738	147791692	49	18942											
CACNA1D	776	broad.mit.edu	37	chr3	53769529	53769529	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccactccttccggaacaCggtaagtccccagggtgggg	8	6	13	14	2	0	0	0	0	0	0	3	1	3	1	5	5	2	1	5	5	2	2	rs145327253		TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:53769529C>T	uc003dgv.3	+	20	2913	c.2750C>T	c.(2749-2751)ACG>ATG	p.T917M	CACNA1D_uc003dgu.3_Missense_Mutation_p.T937M|CACNA1D_uc003dgy.3_Missense_Mutation_p.T917M|CACNA1D_uc003dgw.3_Missense_Mutation_p.T584M|CACNA1D_uc003dgx.1_Missense_Mutation_p.T65M	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	917	Extracellular (Potential).|III.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TTCCGGAACACGGTAAGTCCC	0.622													4	26					0	0	0	0	T	53769529	T	T	53769529	3	4	99	1	0	0	0	0	1	0	0	0	2553	550	19	1	3000	1	CACNA1D	3	53769529	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	3538791	53769529	144252901	50	18943											
CACNA1D	776	broad.mit.edu	37	chr3	53839052	53839052	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agatacccaggcagaaacatCgactctgagaggccccgagg	13	4	12	12	2	1	3	0	1	1	3	2	6	1	3	3	3	2	1	3	3	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:53839052C>G	uc003dgv.3	+	45	5791	c.5628C>G	c.(5626-5628)ATC>ATG	p.I1876M	CACNA1D_uc003dgu.3_Missense_Mutation_p.I1896M|CACNA1D_uc003dgy.3_Missense_Mutation_p.I1852M|CACNA1D_uc003dgw.3_Missense_Mutation_p.I1543M|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1876	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GCAGAAACATCGACTCTGAGA	0.537													15	36					0	0	0	0	G	53839052	G	G	53839052	3	3	99	1	0	0	0	0	1	0	0	0	2553	874	31	3	5978	3	CACNA1D	3	53839052	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	69523	53839052	144183378	51	18944											
MITF	4286	broad.mit.edu	37	chr3	70014097	70014097	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggatcatcaagcaagaacccGttcttgagaactgcagccaa	14	7	9	11	1	3	2	2	1	1	2	3	4	3	3	2	1	5	3	2	1	5	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:70014097G>A	uc003dnz.2	+	10	1377	c.1261G>A	c.(1261-1263)GTT>ATT	p.V421I	MITF_uc011bgb.1_Missense_Mutation_p.V369I|MITF_uc003doa.2_Missense_Mutation_p.V420I|MITF_uc003dob.2_Missense_Mutation_p.V405I|MITF_uc003dod.2_Missense_Mutation_p.V396I|MITF_uc003doe.2_Missense_Mutation_p.V314I|MITF_uc003dof.2_Missense_Mutation_p.V320I	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	427	DNA binding regulation.				melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		GCAAGAACCCGTTCTTGAGAA	0.493			A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						13	43					0	0	0	0	A	70014097	A	A	70014097	3	1	99	1	0	0	0	0	1	0	0	0	9649	1145	40	1	1538	1	MITF	3	70014097	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	16175045	70014097	128008333	52	18945											
EPHA3	2042	broad.mit.edu	37	chr3	89390977	89390977	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tatcctggactggagttggcCcctggacacaggaggccgga	8	7	15	11	1	0	0	0	0	0	0	1	5	1	5	4	7	0	1	4	7	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:89390977C>T	uc003dqy.2	+	5	1268	c.1043C>T	c.(1042-1044)CCC>CTC	p.P348L	EPHA3_uc003dqx.1_Missense_Mutation_p.P348L|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	348	Extracellular (Potential).|Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGGAGTTGGCCCCTGGACACA	0.433										TSP Lung(6;0.00050)			14	36					0	0	0	0	T	89390977	T	T	89390977	3	4	99	1	0	0	0	0	1	0	0	0	5192	623	22	4	1061	4	EPHA3	3	89390977	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	19376880	89390977	108631453	53	18946											
TAGLN3	29114	broad.mit.edu	37	chr3	111732320	111732320	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgccagggacagaacgtaatAggcctgcagatgggcagcaa	13	4	14	10	2	0	2	0	0	0	2	0	3	0	3	2	3	3	4	2	3	4	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:111732320A>C	uc003dym.2	+	5	900	c.522A>C	c.(520-522)ATA>ATC	p.I174I	TAGLN3_uc003dyl.2_Silent_p.I174I|TAGLN3_uc003dyn.2_Silent_p.I174I|TAGLN3_uc003dyo.2_Silent_p.I174I	NM_001008272	NP_001008273	Q9UI15	TAGL3_HUMAN	transgelin 3	174	Calponin-like.				central nervous system development|muscle organ development						0						AGAACGTAATAGGCCTGCAGA	0.577													22	68					0	0	0	0	C	111732320	C	C	111732320	2	2	99	1	0	0	0	0	0	0	0	1	15606	410	15	5		5	TAGLN3	3	111732320	Silent	SNP	A	TCGA-CQ-5334-01A-01D-1683-08	22341343	111732320	86290110	54	18947											
SLC41A3	54946	broad.mit.edu	37	chr3	125786954	125786954	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggggccctgagagctccatCttctgaggctacagggagtc	8	8	14	11	0	2	2	0	2	2	1	4	4	3	3	2	4	2	2	2	4	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:125786954C>T	uc003eij.2	-	2	335	c.109G>A	c.(109-111)GAT>AAT	p.D37N	SLC41A3_uc003eil.2_Missense_Mutation_p.D37N|SLC41A3_uc003eik.2_Missense_Mutation_p.D37N|SLC41A3_uc011bkh.1_Intron|SLC41A3_uc010hsd.1_Missense_Mutation_p.D37N	NM_001008485	NP_001008485	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3 isoform 1	37						integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(114;0.167)		AGAGCTCCATCTTCTGAGGCT	0.642													26	98					0	0	0	0	T	125786954	T	T	125786954	3	4	99	1	0	0	0	0	1	0	0	0	14695	913	32	2	1755	2	SLC41A3	3	125786954	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	14054634	125786954	72235476	55	18948											
EIF2A	83939	broad.mit.edu	37	chr3	150290245	150290245	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccaagtgaagtacccaatGaggaacctaaagttgcaaca	16	8	8	9	0	0	2	0	2	0	0	1	3	1	3	3	1	4	3	3	1	8	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:150290245G>C	uc003eya.2	+	10	1328	c.1312G>C	c.(1312-1314)GAG>CAG	p.E438Q	SERP1_uc003exz.2_Intron|EIF2A_uc003eyb.2_Missense_Mutation_p.E311Q|EIF2A_uc003eyc.2_Missense_Mutation_p.E311Q|EIF2A_uc011bnv.1_Missense_Mutation_p.E413Q|EIF2A_uc011bnw.1_Missense_Mutation_p.E377Q|EIF2A_uc003eyd.2_Missense_Mutation_p.E213Q|uc003eye.1_Intron	NM_032025	NP_114414	Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A	438					regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding				0		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AGTACCCAATGAGGAACCTAA	0.358													17	62					0	0	0	0	C	150290245	C	C	150290245	3	2	99	1	0	0	0	0	1	0	0	0	5017	1291	45	2	1350	2	EIF2A	3	150290245	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	24503291	150290245	47732185	56	18949											
YEATS2	55689	broad.mit.edu	37	chr3	183433041	183433041	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataagcggcataaagcaattGagaattcaggtagaaatcct	17	9	9	6	1	1	2	1	1	0	2	2	3	2	2	1	2	2	3	1	2	7	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr3:183433041G>A	uc003fly.2	+	2	286	c.91G>A	c.(91-93)GAG>AAG	p.E31K		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	31					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TAAAGCAATTGAGAATTCAGG	0.398													13	40					0	0	0	0	A	183433041	A	A	183433041	3	1	99	1	0	0	0	0	1	0	0	0	17540	1291	45	2	93	2	YEATS2	3	183433041	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	33142796	183433041	14589389	57	18950											
SH3BP2	6452	broad.mit.edu	37	chr4	2831567	2831567	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagccctggacccctggcCacggggcctgctccacttcc	4	6	12	19	2	0	0	0	0	0	0	2	2	2	2	7	5	2	1	7	5	0	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr4:2831567C>T	uc003gfi.3	+	8	1054	c.934C>T	c.(934-936)CAC>TAC	p.H312Y	SH3BP2_uc011bvp.1_Missense_Mutation_p.H340Y|SH3BP2_uc003gfj.3_Missense_Mutation_p.H369Y|SH3BP2_uc003gfk.3_Missense_Mutation_p.H312Y|SH3BP2_uc003gfl.3_Missense_Mutation_p.H245Y|SH3BP2_uc003gfm.3_Missense_Mutation_p.H287Y	NM_001122681	NP_001116153	P78314	3BP2_HUMAN	SH3-domain binding protein 2 isoform a	312					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		GACCCCTGGCCACGGGGCCTG	0.672									Cherubism				15	72					0	0	0	0	T	2831567	T	T	2831567	3	4	99	1	0	0	0	0	1	0	0	0	14310	594	21	4	1219	4	SH3BP2	4	2831567	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		2831567	188322709	58	18951											
FNIP2	57600	broad.mit.edu	37	chr4	159789364	159789364	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtcctgacctactttctcCgttgctctgagctacaagag	8	13	8	12	1	2	3	0	2	2	1	4	3	3	3	3	0	4	3	3	0	3	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr4:159789364C>T	uc003iqe.3	+	13	1759	c.1576C>T	c.(1576-1578)CGT>TGT	p.R526C		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	526					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CTACTTTCTCCGTTGCTCTGA	0.498													19	76					0	0	0	0	T	159789364	T	T	159789364	3	4	99	1	0	0	0	0	1	0	0	0	6008	652	23	1	1626	1	FNIP2	4	159789364	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	156957797	159789364	31364912	59	18952											
TARS	6897	broad.mit.edu	37	chr5	33453512	33453512	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtttgaggatgaggaagctCaggcagtaagttgctgatta	12	11	14	4	0	1	3	1	3	0	0	1	5	1	5	0	3	2	6	0	3	3	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr5:33453512C>G	uc003jhy.2	+	4	743	c.448C>G	c.(448-450)CAG>GAG	p.Q150E	TARS_uc011cob.1_Missense_Mutation_p.Q138E|TARS_uc010iup.1_Missense_Mutation_p.Q91E|TARS_uc011coc.1_Missense_Mutation_p.Q171E|TARS_uc003jhz.2_Missense_Mutation_p.Q46E|TARS_uc011cod.1_Intron	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	150					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	TGAGGAAGCTCAGGCAGTAAG	0.438													28	84					0	0	0	0	G	33453512	G	G	33453512	3	3	99	1	0	0	0	0	1	0	0	0	15625	827	29	2	462	2	TARS	5	33453512	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		33453512	147461748	60	18953											
SLC25A46	91137	broad.mit.edu	37	chr5	110097165	110097165	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagtatgttggatgcttatTttccagaacttattgctaac	11	16	8	6	0	0	2	0	0	0	2	1	3	1	3	1	1	4	4	1	1	5	8			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr5:110097165T>C	uc003koz.2	+	8	1007	c.940T>C	c.(940-942)TTT>CTT	p.F314L	SLC25A46_uc011cvi.1_Missense_Mutation_p.F223L	NM_138773	NP_620128	Q96AG3	S2546_HUMAN	solute carrier family 25, member 46	314	Solcar 2.|Helical; Name=5; (Potential).				transport	integral to membrane|mitochondrial inner membrane					0		all_cancers(142;0.00203)|all_epithelial(76;4.52e-05)|Prostate(80;0.0115)|Colorectal(57;0.0676)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;2.58e-09)|Epithelial(69;7.29e-08)|all cancers(49;9.35e-06)|COAD - Colon adenocarcinoma(37;0.211)		GGATGCTTATTTTCCAGAACT	0.408													41	180					0	0	0	0	C	110097165	C	C	110097165	3	2	99	1	0	0	0	0	1	0	0	0	14575	1841	64	5	970	5	SLC25A46	5	110097165	Missense_Mutation	SNP	T	TCGA-CQ-5334-01A-01D-1683-08	76643653	110097165	70818095	61	18954											
BRD8	10902	broad.mit.edu	37	chr5	137500615	137500615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaggttccaccttgatctCtgcactgggctccctgatgt	5	13	10	13	0	1	2	0	2	1	0	4	2	3	2	3	2	2	4	3	2	0	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr5:137500615C>T	uc003lcf.1	-	12	1574	c.1519G>A	c.(1519-1521)GAG>AAG	p.E507K	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Missense_Mutation_p.E286K|BRD8_uc003lcg.2_Missense_Mutation_p.E580K|BRD8_uc003lci.2_Missense_Mutation_p.E510K|BRD8_uc003lch.2_Missense_Mutation_p.E401K|BRD8_uc011cym.1_Missense_Mutation_p.E491K|BRD8_uc010jer.1_Missense_Mutation_p.E476K|BRD8_uc011cyn.1_Missense_Mutation_p.E466K	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	507					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ACCTTGATCTCTGCACTGGGC	0.512													18	85					0	0	0	0	T	137500615	T	T	137500615	3	4	99	1	0	0	0	0	1	0	0	0	1511	922	32	2	2316	2	BRD8	5	137500615	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	27403450	137500615	43414645	62	18955											
PCDHA4	56144	broad.mit.edu	37	chr5	140188125	140188125	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggctgatgtgaacgacaaCgctccggcgttcgcgcagcc	7	7	14	13	6	0	2	0	2	0	0	2	3	1	2	2	2	3	4	2	2	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr5:140188125C>T	uc003lhi.2	+	1	1454	c.1353C>T	c.(1351-1353)AAC>AAT	p.N451N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.N451N|PCDHA4_uc011daa.1_Silent_p.N451N	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACAACGCTCCGGCGT	0.647													23	74					0	0	0	0	T	140188125	T	T	140188125	2	4	99	1	0	0	0	0	0	0	0	1	11580	535	19	1		1	PCDHA4	5	140188125	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	2687510	140188125	40727135	63	18956											
ATP10B	23120	broad.mit.edu	37	chr5	160059205	160059205	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atagacctttgccggtagtgGccctggatgggcacccgggc	6	8	15	12	2	0	1	0	0	0	1	0	2	0	2	4	5	1	2	4	5	2	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr5:160059205G>T	uc003lym.1	-	13	2398	c.1551C>A	c.(1549-1551)GGC>GGA	p.G517G	ATP10B_uc003lyn.2_Silent_p.G75G	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	517	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCCGGTAGTGGCCCTGGATGG	0.567													7	43					2.7689e-08	3.00071e-08	1	0	T	160059205	T	T	160059205	2	4	99	1	0	0	0	0	0	0	0	1	1119	1190	42	4		4	ATP10B	5	160059205	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	19871080	160059205	20856055	64	18957											
GPRIN1	114787	broad.mit.edu	37	chr5	176025708	176025708	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgaggaggcagggtccatCtttcccaggaaccgggagtc	8	7	14	12	1	1	1	0	1	1	0	4	4	3	4	4	5	1	1	4	5	1	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr5:176025708C>G	uc003meo.1	-	2	1303	c.1128G>C	c.(1126-1128)AAG>AAC	p.K376N		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	376						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGGGTCCATCTTTCCCAGGA	0.542													9	48					0	0	0	0	G	176025708	G	G	176025708	3	3	99	1	0	0	0	0	1	0	0	0	6768	912	32	2	1902	2	GPRIN1	5	176025708	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	15966503	176025708	4889552	65	18958											
GCM2	9247	broad.mit.edu	37	chr6	10876748	10876748	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atccgctgtgccctcgacaaGgaatcaactccaaagcagaa	14	6	8	13	2	1	1	1	0	0	1	4	3	3	2	3	1	3	2	3	1	5	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:10876748G>C	uc003mzn.3	-	3	458	c.386C>G	c.(385-387)CCT>CGT	p.P129R	SYCP2L_uc011dim.1_Intron	NM_004752	NP_004743	O75603	GCM2_HUMAN	glial cells missing homolog 2	129	GCM.				cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				CCCTCGACAAGGAATCAACTC	0.493													16	18					0	0	0	0	C	10876748	C	C	10876748	3	2	99	1	0	0	0	0	1	0	0	0	6333	1000	35	4	1146	4	GCM2	6	10876748	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08		10876748	160238319	66	18959											
HIST1H3J	8356	broad.mit.edu	37	chr6	27858539	27858539	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggtgccttgccgccggtaGacttgcgagctgtctgcttc	3	11	14	13	4	1	1	0	0	1	1	2	2	1	1	3	2	5	3	3	2	1	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:27858539G>T	uc003nka.2	-	1	32	c.32C>A	c.(31-33)TCT>TAT	p.S11Y	HIST1H2BO_uc003nkc.1_5'Flank	NM_003535	NP_003526	P68431	H31_HUMAN	histone cluster 1, H3j	11					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GCCGCCGGTAGACTTGCGAGC	0.582													5	34					8.12818e-05	8.49268e-05	1	0	T	27858539	T	T	27858539	3	4	99	1	0	0	0	0	1	0	0	0	7203	942	33	2	382	2	HIST1H3J	6	27858539	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	16981791	27858539	143256528	67	18960											
NOTCH4	4855	broad.mit.edu	37	chr6	32166457	32166457	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctccctcctcagggcctGagcacatcacaactccatcc	8	8	5	20	0	3	1	2	1	1	0	7	1	6	1	6	1	2	1	6	1	1	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:32166457G>C	uc003obb.2	-	25	4725	c.4586C>G	c.(4585-4587)TCA>TGA	p.S1529*	NOTCH4_uc011dpt.1_5'Flank|NOTCH4_uc003oba.2_Nonsense_Mutation_p.S192*|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_5'Flank	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1529	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CTCAGGGCCTGAGCACATCAC	0.542													6	27					0	0	0	0	C	32166457	C	C	32166457	4	2	99	1	0	0	0	0	0	1	0	0	10605	1294	45	2	1449	2	NOTCH4	6	32166457	Nonsense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	4307918	32166457	138948610	68	18961											
ZBTB22	9278	broad.mit.edu	37	chr6	33283438	33283442	+	Frame_Shift_Del	DEL	AAGGG	-	-																															tctggttgccctgcatgtccAagggaaggagcggtcgagga																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:33283438_33283442delAAGGG	uc003oeb.2	-	2	1404_1408	c.1252_1256delCCCTT	c.(1252-1257)CCCTTGfs	p.P418fs	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Frame_Shift_Del_p.P418fs	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	418_419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTGCATGTCCAAGGGAAGGAGCGGT	0.62													---	---	---								-	33283442	-	-	33283438	7	5	99	1	0	1	0	1	0	0	0	0	17597	131	5	0	652	0	ZBTB22	6	33283438	Frame_Shift_Del	DEL	AAGGG	TCGA-CQ-5334-01A-01D-1683-08	1116981	33283438	137831629	69	18962											
PHF1	5252	broad.mit.edu	37	chr6	33382536	33382536	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagattaagaagaggaaaTgtttgtttggtctccatgct	12	13	12	4	0	1	3	0	0	1	3	2	6	1	4	1	2	1	3	1	2	3	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:33382536T>A	uc003oeh.2	+	11	1215	c.979T>A	c.(979-981)TGT>AGT	p.C327S	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Missense_Mutation_p.C327S|PHF1_uc010jux.2_Missense_Mutation_p.C127S	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	327					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				GAAGAGGAAATGTTTGTTTGG	0.512											OREG0017346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	115					0	0	0	0	A	33382536	A	A	33382536	3	1	99	1	0	0	0	0	1	0	0	0	11875	1464	51	5	1017	5	PHF1	6	33382536	Missense_Mutation	SNP	T	TCGA-CQ-5334-01A-01D-1683-08	99098	33382536	137732531	70	18963											
SYNGAP1	8831	broad.mit.edu	37	chr6	33403058	33403058	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aagccagtgcacagctccatCctgggccaggagttctgttt	8	10	11	12	0	1	0	0	0	1	0	3	1	3	1	4	2	3	4	4	2	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:33403058C>G	uc011dri.1	+	6	834	c.639C>G	c.(637-639)ATC>ATG	p.I213M	SYNGAP1_uc003oeo.1_Missense_Mutation_p.I198M|SYNGAP1_uc010juy.2_Missense_Mutation_p.I198M|SYNGAP1_uc010juz.2_5'Flank	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	213	PH.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						ACAGCTCCATCCTGGGCCAGG	0.552													24	43					0	0	0	0	G	33403058	G	G	33403058	3	3	99	1	0	0	0	0	1	0	0	0	15513	845	30	2	661	2	SYNGAP1	6	33403058	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	20522	33403058	137712009	71	18964											
PPP2R5D	5528	broad.mit.edu	37	chr6	42975737	42975737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctcaagaccattttgcatcGcatctatggcaagtttttgg	9	14	8	10	1	2	1	1	0	1	1	3	1	2	1	2	2	1	4	2	2	3	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:42975737G>A	uc003oth.2	+	7	877	c.791G>A	c.(790-792)CGC>CAC	p.R264H	MEA1_uc010jyc.1_Intron|PPP2R5D_uc003otg.2_Missense_Mutation_p.R232H|PPP2R5D_uc010jyd.2_Missense_Mutation_p.R158H|PPP2R5D_uc011dva.1_Missense_Mutation_p.R113H|PPP2R5D_uc003oti.2_Missense_Mutation_p.R113H|PPP2R5D_uc003otj.2_Missense_Mutation_p.R113H	NM_006245	NP_006236	Q14738	2A5D_HUMAN	delta isoform of regulatory subunit B56, protein	264					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			breast(1)|central_nervous_system(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			ATTTTGCATCGCATCTATGGC	0.542													21	97					0	0	0	0	A	42975737	A	A	42975737	3	1	99	1	0	0	0	0	1	0	0	0	12455	1087	38	1	817	1	PPP2R5D	6	42975737	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	9572679	42975737	128139330	72	18965											
PTK7	5754	broad.mit.edu	37	chr6	43109979	43109979	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggactcaggccgctacacCtgcattgcaggcaacagctg	10	6	12	13	1	1	0	1	0	0	0	1	2	1	1	2	3	5	5	2	3	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:43109979C>T	uc003oub.1	+	13	2187	c.1989C>T	c.(1987-1989)ACC>ACT	p.T663T	PTK7_uc003ouc.1_Intron|PTK7_uc003oud.1_Silent_p.T623T|PTK7_uc003oue.1_Silent_p.T533T|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Silent_p.T671T|PTK7_uc010jyj.1_Intron	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	663	Ig-like C2-type 7.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GCCGCTACACCTGCATTGCAG	0.607													24	26					0	0	0	0	T	43109979	T	T	43109979	2	4	99	1	0	0	0	0	0	0	0	1	12828	668	24	4		4	PTK7	6	43109979	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	134242	43109979	128005088	73	18966											
CUL9	23113	broad.mit.edu	37	chr6	43173028	43173028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagtttgccaggtacattGaccaacagatccagggtggc	11	8	12	10	0	0	2	0	1	0	1	1	2	1	2	3	3	4	3	3	3	2	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:43173028G>A	uc003ouk.2	+	24	4735	c.4660G>A	c.(4660-4662)GAC>AAC	p.D1554N	CUL9_uc003oul.2_Missense_Mutation_p.D1554N|CUL9_uc010jyk.2_Missense_Mutation_p.D706N	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1554					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CAGGTACATTGACCAACAGAT	0.567													43	215					0	0	0	0	A	43173028	A	A	43173028	3	1	99	1	0	0	0	0	1	0	0	0	4078	1290	45	2	4750	2	CUL9	6	43173028	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	63049	43173028	127942039	74	18967											
MCM9	254394	broad.mit.edu	37	chr6	119245037	119245037	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggagacgaagacaagcctGagaggcaagtgaatttagag	15	7	14	5	1	0	5	0	2	0	4	0	8	0	5	1	2	1	1	1	2	5	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:119245037G>C	uc003pyh.2	-	3	823	c.560C>G	c.(559-561)TCA>TGA	p.S187*		NM_153255	NP_694987	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	187					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			ovary(1)	1		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		AGACAAGCCTGAGAGGCAAGT	0.418													14	57					0	0	0	0	C	119245037	C	C	119245037	4	2	99	1	0	0	0	0	0	1	0	0	9447	1294	45	2	635	2	MCM9	6	119245037	Nonsense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	76072009	119245037	51870030	75	18968											
NKAIN2	154215	broad.mit.edu	37	chr6	124676415	124676415	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcttgcttctctacagtaTgctgtctggctagtcctctg	4	17	8	12	0	4	0	0	0	4	0	7	0	5	0	1	1	3	4	1	1	3	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:124676415T>C	uc003pzo.2	+	3	472	c.195T>C	c.(193-195)TAT>TAC	p.Y65Y	NKAIN2_uc003pzn.1_Silent_p.Y65Y|NKAIN2_uc003pzp.2_Silent_p.Y64Y|NKAIN2_uc010keq.2_Silent_p.Y65Y|NKAIN2_uc010ker.2_5'UTR	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	65	Helical; (Potential).					integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		CTCTACAGTATGCTGTCTGGC	0.373													30	140					0	0	0	0	C	124676415	C	C	124676415	2	2	99	1	0	0	0	0	0	0	0	1	10490	1471	51	5		5	NKAIN2	6	124676415	Silent	SNP	T	TCGA-CQ-5334-01A-01D-1683-08	5431378	124676415	46438652	76	18969											
SHPRH	257218	broad.mit.edu	37	chr6	146247400	146247400	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgggtgcctggctatcaaCaattccatcaagttatgggt	9	12	10	10	0	2	0	2	0	0	0	3	0	3	0	3	3	2	2	3	3	5	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:146247400C>T	uc003qlf.2	-	16	3633	c.3234G>A	c.(3232-3234)TTG>TTA	p.L1078L	SHPRH_uc003qld.2_Silent_p.L1087L|SHPRH_uc003qle.2_Silent_p.L1087L|SHPRH_uc003qlg.1_Silent_p.L634L|SHPRH_uc003qlh.2_Silent_p.L3L|SHPRH_uc003qli.1_Silent_p.L3L	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1078					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TGGCTATCAACAATTCCATCA	0.383													15	73					0	0	0	0	T	146247400	T	T	146247400	2	4	99	1	0	0	0	0	0	0	0	1	14356	477	17	4		4	SHPRH	6	146247400	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	21570985	146247400	24867667	77	18970											
CNKSR3	154043	broad.mit.edu	37	chr6	154727688	154727688	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accccggaccagatgccgctCggtcgtgggtctggagaacc	7	6	14	14	4	1	2	0	0	1	2	3	4	1	3	5	4	2	1	5	4	1	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr6:154727688C>T	uc003qpy.2	-	13	1973	c.1468G>A	c.(1468-1470)GAG>AAG	p.E490K		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	490	DUF1170.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		AGATGCCGCTCGGTCGTGGGT	0.582													15	77					0	0	0	0	T	154727688	T	T	154727688	3	4	99	1	0	0	0	0	1	0	0	0	3623	893	31	1	203	1	CNKSR3	6	154727688	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	8480288	154727688	16387379	78	18971											
SNX8	29886	broad.mit.edu	37	chr7	2296548	2296548	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgagagttgacgaaggcgcgGaggatgtgggaggtgagggg	9	6	23	3	3	0	3	0	3	0	1	0	8	0	6	0	7	0	1	0	7	1	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr7:2296548G>A	uc003slw.2	-	10	1288	c.1245C>T	c.(1243-1245)CTC>CTT	p.L415L		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	415					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CGAAGGCGCGGAGGATGTGGG	0.627													9	33					0	0	0	0	A	2296548	A	A	2296548	2	1	99	1	0	0	0	0	0	0	0	1	14972	1161	41	2		2	SNX8	7	2296548	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08		2296548	156842115	79	18972											
CREB5	9586	broad.mit.edu	37	chr7	28844023	28844023	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcacaccatcctcaccctCaaccccatcaccagcagaac	13	4	3	21	0	3	1	3	0	0	1	4	1	4	1	6	0	4	2	6	0	2	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr7:28844023C>G	uc003szq.2	+	8	1300	c.910C>G	c.(910-912)CAA>GAA	p.Q304E	CREB5_uc003szo.2_Missense_Mutation_p.Q271E|CREB5_uc003szr.2_Missense_Mutation_p.Q297E|CREB5_uc003szs.2_Missense_Mutation_p.Q165E	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	304					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						tcctcaccctcaaccccatca	0.124													11	25					0	0	0	0	G	28844023	G	G	28844023	3	3	99	1	0	0	0	0	1	0	0	0	3875	827	29	2	991	2	CREB5	7	28844023	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	26547475	28844023	130294640	80	18973											
CCDC129	223075	broad.mit.edu	37	chr7	31683179	31683179	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttggggactggtcccagagGaacatctttagaatgcactg	10	10	12	9	0	1	2	0	0	1	2	2	4	2	4	1	4	2	1	1	4	3	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr7:31683179G>T	uc003tcj.1	+	11	3188	c.2195G>T	c.(2194-2196)GGA>GTA	p.G732V	CCDC129_uc011kad.1_Missense_Mutation_p.G742V|CCDC129_uc003tci.1_Missense_Mutation_p.G583V|CCDC129_uc011kae.1_Missense_Mutation_p.G758V|CCDC129_uc003tck.1_Missense_Mutation_p.G640V	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	732											0						GGTCCCAGAGGAACATCTTTA	0.507													14	62					4.93089e-13	5.60438e-13	1	0	T	31683179	T	T	31683179	3	4	99	1	0	0	0	0	1	0	0	0	2776	1174	41	2	2233	2	CCDC129	7	31683179	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	2839156	31683179	127455484	81	18974											
MYO1G	64005	broad.mit.edu	37	chr7	45005749	45005749	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaccagtgtccggggtgagcGgatgaacagcttgctgtggc	7	8	17	9	2	0	2	0	2	0	0	1	4	1	3	2	4	4	2	2	4	1	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr7:45005749G>A	uc003tmh.2	-	16	2224	c.2080C>T	c.(2080-2082)CGC>TGC	p.R694C	MYO1G_uc003tmf.2_Missense_Mutation_p.R137C|MYO1G_uc003tmg.2_Missense_Mutation_p.R456C|MYO1G_uc010kym.2_Missense_Mutation_p.R579C|MYO1G_uc003tmi.1_3'UTR	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	694						myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						CGGGGTGAGCGGATGAACAGC	0.647													8	37					0	0	0	0	A	45005749	A	A	45005749	3	1	99	1	0	0	0	0	1	0	0	0	10127	1116	39	1	1004	1	MYO1G	7	45005749	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	13322570	45005749	114132914	82	18975											
GTF2I	2969	broad.mit.edu	37	chr7	74114630	74114630	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taccatatgagaagatgctgCgagaccagtcggctgtggta	11	9	13	8	2	0	3	0	1	0	3	1	5	0	3	2	2	3	3	2	2	4	3	rs1064765	byFrequency	TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr7:74114630C>T	uc003uau.2	+	5	797	c.427C>T	c.(427-429)CGA>TGA	p.R143*	GTF2I_uc003uat.2_Nonsense_Mutation_p.R143*|GTF2I_uc003uav.2_Nonsense_Mutation_p.R143*|GTF2I_uc003uaw.2_Nonsense_Mutation_p.R143*|GTF2I_uc003uay.2_Nonsense_Mutation_p.R143*|GTF2I_uc003uax.2_Nonsense_Mutation_p.R143*|uc003uaz.2_RNA	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	143	GTF2I-like 1.				negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						GAAGATGCTGCGAGACCAGTC	0.478													11	72					0	0	0	0	T	74114630	T	T	74114630	4	4	99	1	0	0	0	0	0	1	0	0	6906	760	27	1	441	1	GTF2I	7	74114630	Nonsense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	29108881	74114630	85024033	83	18976											
PLOD3	8985	broad.mit.edu	37	chr7	100849690	100849690	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggggaggagatcacacagtCgtagcgcaggaagcggcagc	11	3	17	10	4	1	1	1	0	0	1	2	4	1	3	0	5	3	3	0	5	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr7:100849690C>T	uc003uyd.2	-	19	2545	c.2089G>A	c.(2089-2091)GAC>AAC	p.D697N	PLOD3_uc010lhs.2_Missense_Mutation_p.D262N	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	697	Fe2OG dioxygenase.				protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	ATCACACAGTCGTAGCGCAGG	0.652													7	19					0	0	0	0	T	100849690	T	T	100849690	3	4	99	1	0	0	0	0	1	0	0	0	12158	884	31	1	131	1	PLOD3	7	100849690	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	26735060	100849690	58288973	84	18977											
LMOD2	442721	broad.mit.edu	37	chr7	123301995	123301997	+	In_Frame_Del	DEL	GAG	-	-																															tttctgaggaagtgtatacaGaggaggaggaggaggagtcc																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr7:123301995_123301997delGAG	uc003vky.2	+	2	512_514	c.355_357delGAG	c.(355-357)GAGdel	p.E124del		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	124	Glu-rich.|Potential.					cytoskeleton	actin binding|tropomyosin binding				0						AGTGTATACAgaggaggaggagg	0.281													---	---	---								-	123301997	-	-	123301995	7	5	99	1	0	1	0	1	0	0	0	0	8899	943	33	0	361	0	LMOD2	7	123301995	In_Frame_Del	DEL	GAG	TCGA-CQ-5334-01A-01D-1683-08	22452305	123301995	35836668	85	18978											
SSPO	23145	broad.mit.edu	37	chr7	149493600	149493600	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggagctgctgggctgcgagCcaggtacaggttgcgcaggg	6	7	19	9	2	0	0	0	0	0	0	0	2	0	1	1	5	6	6	1	5	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr7:149493600C>T	uc010lpk.2	+	45	6676	c.6676C>T	c.(6676-6678)CCA>TCA	p.P2226S		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2226					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGGCTGCGAGCCAGGTACAGG	0.672													15	68					0	0	0	0	T	149493600	T	T	149493600	3	4	99	1	0	0	0	0	1	0	0	0	15255	739	26	4	6846	4	SSPO	7	149493600	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	26191605	149493600	9645063	86	18979											
UBR5	51366	broad.mit.edu	37	chr8	103305964	103305964	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacgagcaatccccattctGacaggaacaatcagtgactc	13	7	9	12	1	2	2	1	2	1	0	4	5	3	4	2	2	2	1	2	2	3	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr8:103305964G>C	uc003ykr.1	-	34	4491	c.4458C>G	c.(4456-4458)GTC>GTG	p.V1486V	UBR5_uc003yks.1_Silent_p.V1486V	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1486					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TCCCCATTCTGACAGGAACAA	0.463													4	21					0	0	0	0	C	103305964	C	C	103305964	2	2	99	1	0	0	0	0	0	0	0	1	16973	1277	45	2		2	UBR5	8	103305964	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08		103305964	43058058	87	18980											
BAI1	575	broad.mit.edu	37	chr8	143562715	143562715	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgactacagaaacatccaGatgatggtgagggccagttc	13	9	11	8	0	0	5	0	3	0	2	2	5	1	5	2	2	2	1	2	2	2	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr8:143562715G>C	uc003ywm.2	+	9	2112	c.1929G>C	c.(1927-1929)CAG>CAC	p.Q643H		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	643	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GAAACATCCAGATGATGGTGA	0.607													16	66					0	0	0	0	C	143562715	C	C	143562715	3	2	99	1	0	0	0	0	1	0	0	0	1300	933	33	2	1963	2	BAI1	8	143562715	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	40256751	143562715	2801307	88	18981											
LY6D	8581	broad.mit.edu	37	chr8	143866646	143866646	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggggggaaggtcacaggctGggggctaagatgacggccag	9	5	20	7	1	1	2	1	1	0	1	1	3	1	3	1	8	0	2	1	8	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr8:143866646G>A	uc003yxf.1	-	3	454	c.378C>T	c.(376-378)CCC>CCT	p.P126P		NM_003695	NP_003686	Q14210	LY6D_HUMAN	lymphocyte antigen 6 complex, locus D precursor	126					cell adhesion	anchored to membrane|membrane fraction|plasma membrane	protein binding				0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GTCACAGGCTGGGGGCTAAGA	0.667													5	21					0	0	0	0	A	143866646	A	A	143866646	2	1	99	1	0	0	0	0	0	0	0	1	9141	1335	47	4		4	LY6D	8	143866646	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	303931	143866646	2497376	89	18982											
EPPK1	83481	broad.mit.edu	37	chr8	144940413	144940413	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatctgggcctccagcaggcGgatgccgtgctcccggacga	6	6	15	14	4	1	0	0	0	1	0	3	4	3	2	4	4	3	2	4	4	0	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr8:144940413G>A	uc003zaa.1	-	2	15032	c.15019C>T	c.(15019-15021)CGC>TGC	p.R5007C		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5007	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCCAGCAGGCGGATGCCGTGC	0.701													9	397					0	0	0	0	A	144940413	A	A	144940413	3	1	99	1	0	0	0	0	1	0	0	0	5214	1116	39	1	257	1	EPPK1	8	144940413	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	1073767	144940413	1423609	90	18983											
NFKBIL2	4796	broad.mit.edu	37	chr8	145661383	145661383	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggctttgctgtggccccgCggtgggccaggccccagccg	3	6	17	15	3	0	0	0	0	0	0	0	0	0	0	6	5	2	2	6	5	0	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr8:145661383C>T	uc011llg.1	-	17	2448	c.2433G>A	c.(2431-2433)CCG>CCA	p.P811P	uc011llh.1_Intron	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	811					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TGTGGCCCCGCGGTGGGCCAG	0.721													6	13					0	0	0	0	T	145661383	T	T	145661383	2	4	99	1	0	0	0	0	0	0	0	1	10436	755	27	1		1	NFKBIL2	8	145661383	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	720970	145661383	702639	91	18984											
ALDH1B1	219	broad.mit.edu	37	chr9	38396723	38396723	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgctggctcccggaccttCgtggaagaatccatctacaa	9	10	10	12	2	1	1	0	0	1	1	4	3	3	3	3	3	2	2	3	3	4	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr9:38396723C>T	uc004aay.2	+	2	1090	c.978C>T	c.(976-978)TTC>TTT	p.F326F		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	326					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	CCCGGACCTTCGTGGAAGAAT	0.577													8	33					0	0	0	0	T	38396723	T	T	38396723	2	4	99	1	0	0	0	0	0	0	0	1	493	883	31	1		1	ALDH1B1	9	38396723	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		38396723	102816708	92	18985											
TRPM6	140803	broad.mit.edu	37	chr9	77343238	77343238	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcttcccccaaattggccGgtccaaacaccattcctctt	9	11	4	17	1	2	0	0	0	2	0	5	0	5	0	6	2	1	0	6	2	2	4	rs143161006		TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr9:77343238G>A	uc004ajl.1	-	38	6090	c.5852C>T	c.(5851-5853)CCG>CTG	p.P1951L	TRPM6_uc004ajk.1_Missense_Mutation_p.P1946L|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.P902L|TRPM6_uc010mpd.1_Missense_Mutation_p.P784L|TRPM6_uc010mpe.1_Missense_Mutation_p.P498L|TRPM6_uc004ajj.1_Missense_Mutation_p.P907L	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1951	ATP (By similarity).|Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CAAATTGGCCGGTCCAAACAC	0.428													12	33					0	0	0	0	A	77343238	A	A	77343238	3	1	99	1	0	0	0	0	1	0	0	0	16657	1116	39	1	224	1	TRPM6	9	77343238	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	38946515	77343238	63870193	93	18986											
ABCA1	19	broad.mit.edu	37	chr9	107571747	107571747	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggctaaagtggcactcacGggattgggtttccttccata	9	12	11	9	1	1	0	1	0	0	0	3	1	3	1	2	4	0	3	2	4	3	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr9:107571747G>A	uc004bcl.2	-	30	4587	c.4274C>T	c.(4273-4275)CCA>CTA	p.P1425L		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1425	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGGCACTCACGGGATTGGGTT	0.512													10	25					0	0	0	0	A	107571747	A	A	107571747	3	1	99	1	0	0	0	0	1	0	0	0	28	1130	39	1	2595	1	ABCA1	9	107571747	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	30228509	107571747	33641684	94	18987											
FNBP1	23048	broad.mit.edu	37	chr9	132687418	132687418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaccctgatttataagcttCtattaccagctgtgaatcct	12	14	5	10	0	1	2	0	2	1	0	2	2	2	2	3	0	4	2	3	0	6	6			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr9:132687418C>T	uc004byw.1	-	9	1027	c.808G>A	c.(808-810)GAA>AAA	p.E270K	FNBP1_uc011mbv.1_Missense_Mutation_p.E270K|FNBP1_uc011mbw.1_Missense_Mutation_p.E270K|FNBP1_uc004bza.2_Missense_Mutation_p.E270K|FNBP1_uc004byz.1_Missense_Mutation_p.E270K|FNBP1_uc004byx.1_Missense_Mutation_p.E191K|FNBP1_uc004byy.1_Missense_Mutation_p.E191K	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	270	Interaction with microtubules (By similarity).|Required for self-association and induction of membrane tubulation.|Self-association, lipid-binding and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		TTATAAGCTTCTATTACCAGC	0.343			T	MLL	AML								13	46					0	0	0	0	T	132687418	T	T	132687418	3	4	99	1	0	0	0	0	1	0	0	0	5997	922	32	2	1081	2	FNBP1	9	132687418	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	25115671	132687418	8526013	95	18988											
DBH	1621	broad.mit.edu	37	chr9	136522324	136522326	+	In_Frame_Del	DEL	CAA	-	-																															gcgcccatctccatgcactgCaacaagtcctcagccgtccg																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr9:136522324_136522326delCAA	uc004cel.2	+	11	1704_1706	c.1695_1697delCAA	c.(1693-1698)TGCAAC>TGC	p.N566del	uc010nao.1_In_Frame_Del_p.L19del	NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	566	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CCATGCACTGCAACAAGTCCTCA	0.64													---	---	---								-	136522326	-	-	136522324	7	5	99	1	0	1	0	1	0	0	0	0	4267	718	25	0	1737	0	DBH	9	136522324	In_Frame_Del	DEL	CAA	TCGA-CQ-5334-01A-01D-1683-08	3834906	136522324	4691107	96	18989											
NOTCH1	4851	broad.mit.edu	37	chr9	139402562	139402562	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgtccacacagagccctcCatgctggcacaggcgggcaa	9	4	12	16	3	0	1	0	0	0	1	2	1	2	1	3	3	2	3	3	3	1	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr9:139402562C>A	uc004chz.2	-	21	3355	c.3355G>T	c.(3355-3357)GGA>TGA	p.G1119*	NOTCH1_uc004cia.1_Nonsense_Mutation_p.G349*	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1119	Extracellular (Potential).|EGF-like 29.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CAGAGCCCTCCATGCTGGCAC	0.672			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			10	25					2.17888e-05	2.28684e-05	1	0	A	139402562	A	A	139402562	4	1	99	1	0	0	0	0	0	1	0	0	10601	603	21	4	4368	4	NOTCH1	9	139402562	Nonsense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	2880238	139402562	1810869	97	18990											
ITGB1	3688	broad.mit.edu	37	chr10	33211192	33211193	+	Missense_Mutation	DNP	GC	AA	AA																															aagatgtactcacattgtatGcatcaatgatcaactgaatt																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr10:33211192_33211193GC>AA	uc001iws.3	-	9	1256_1257	c.1120_1121GC>TT	c.(1120-1122)GCA>TTA	p.A374L	ITGB1_uc001iwp.3_Missense_Mutation_p.A374L|ITGB1_uc001iwq.3_Missense_Mutation_p.A374L|ITGB1_uc001iwr.3_Missense_Mutation_p.A374L|ITGB1_uc001iwt.3_Missense_Mutation_p.A374L|ITGB1_uc001iwu.1_Missense_Mutation_p.A374L	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	374	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				CACATTGTATGCATCAATGATC	0.327													12	52					0	0	0	0	AA	33211193	AA	AA	33211192	3	1	99	1	0	0	0	0	1	0	0	0	7929	1319	46	4	1545	4	ITGB1	10	33211192	Missense_Mutation	DNP	GC	TCGA-CQ-5334-01A-01D-1683-08		33211192	102323555	98	18991											
FAM13C	220965	broad.mit.edu	37	chr10	61112119	61112119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcccatgctgggtcgcaataCgctgtccaccagcacggtcg	7	7	12	15	4	0	0	0	0	0	0	3	0	1	0	3	2	3	4	3	2	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr10:61112119C>T	uc001jkn.2	-	4	369	c.235G>A	c.(235-237)GTA>ATA	p.V79I	FAM13C_uc001jko.2_Missense_Mutation_p.V79I|FAM13C_uc010qid.1_5'UTR|FAM13C_uc010qie.1_5'UTR|FAM13C_uc010qif.1_Missense_Mutation_p.V101I|FAM13C_uc001jkp.2_5'UTR	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	79										ovary(2)	2						GGTCGCAATACGCTGTCCACC	0.607													5	28					0	0	0	0	T	61112119	T	T	61112119	3	4	99	1	0	0	0	0	1	0	0	0	5482	536	19	1	1570	1	FAM13C	10	61112119	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	27900927	61112119	74422628	99	18992											
FAM13C	220965	broad.mit.edu	37	chr10	61112150	61112150	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcacggtcgcctctacattCtgctgctgcggctcccaaga	7	9	10	15	3	2	1	0	0	2	1	4	1	3	1	2	2	5	4	2	2	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr10:61112150C>T	uc001jkn.2	-	4	338	c.204G>A	c.(202-204)CAG>CAA	p.Q68Q	FAM13C_uc001jko.2_Silent_p.Q68Q|FAM13C_uc010qid.1_5'UTR|FAM13C_uc010qie.1_5'UTR|FAM13C_uc010qif.1_Silent_p.Q90Q|FAM13C_uc001jkp.2_5'UTR	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	68										ovary(2)	2						CCTCTACATTCTGCTGCTGCG	0.562													3	19					0	0	0	0	T	61112150	T	T	61112150	2	4	99	1	0	0	0	0	0	0	0	1	5482	912	32	2		2	FAM13C	10	61112150	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	31	61112150	74422597	100	18993											
VCL	7414	broad.mit.edu	37	chr10	75856965	75856965	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaacaatgtttttaaggatCtaaaagctcggatgcaggag	15	11	10	5	1	1	0	0	0	1	0	2	3	1	3	0	3	3	3	0	3	6	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr10:75856965C>A	uc001jwd.2	+	13	1841	c.1747C>A	c.(1747-1749)CTA>ATA	p.L583I	VCL_uc009xrr.2_Missense_Mutation_p.L332I|VCL_uc010qky.1_Missense_Mutation_p.L490I|VCL_uc001jwe.2_Missense_Mutation_p.L583I|VCL_uc010qkz.1_Intron	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	583	N-terminal globular head.|3.|3 X 112 AA tandem repeats.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					TTTTAAGGATCTAAAAGCTCG	0.438													16	94					1.52009e-12	1.71102e-12	1	0	A	75856965	A	A	75856965	3	1	99	1	0	0	0	0	1	0	0	0	17207	912	32	2	1797	2	VCL	10	75856965	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	14744815	75856965	59677782	101	18994											
VCL	7414	broad.mit.edu	37	chr10	75857067	75857067	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagtggcagccacggcgcctCctgatgcgcctaacagggaa	9	5	13	14	3	0	1	0	1	0	0	1	2	1	2	4	3	3	1	4	3	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr10:75857067C>T	uc001jwd.2	+	13	1943	c.1849C>T	c.(1849-1851)CCT>TCT	p.P617S	VCL_uc009xrr.2_Missense_Mutation_p.P366S|VCL_uc010qky.1_Missense_Mutation_p.P524S|VCL_uc001jwe.2_Missense_Mutation_p.P617S|VCL_uc010qkz.1_Intron	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	617	N-terminal globular head.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					CACGGCGCCTCCTGATGCGCC	0.502													16	75					0	0	0	0	T	75857067	T	T	75857067	3	4	99	1	0	0	0	0	1	0	0	0	17207	855	30	2	1899	2	VCL	10	75857067	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	102	75857067	59677680	102	18995											
IFIT3	3437	broad.mit.edu	37	chr10	91099031	91099031	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagctgagtcctgataacCaatacgtcaaggttctcttg	10	13	9	9	1	2	3	1	3	1	0	4	3	3	3	2	1	3	2	2	1	4	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr10:91099031C>T	uc001kgf.2	+	2	848	c.619C>T	c.(619-621)CAA>TAA	p.Q207*	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron|IFIT3_uc001kgg.2_Nonsense_Mutation_p.Q207*	NM_001549	NP_001540	O14879	IFIT3_HUMAN	interferon-induced protein with	207	TPR 5.				type I interferon-mediated signaling pathway		protein binding			central_nervous_system(1)	1						TCCTGATAACCAATACGTCAA	0.453													11	33					0	0	0	0	T	91099031	T	T	91099031	4	4	99	1	0	0	0	0	0	1	0	0	7563	595	21	4	634	4	IFIT3	10	91099031	Nonsense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	15241964	91099031	44435716	103	18996											
BTRC	8945	broad.mit.edu	37	chr10	103190136	103190136	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtctctgtggctgggctgctCcagcctggcggacagcatgc	4	9	15	13	1	1	0	0	0	1	0	3	1	2	1	2	4	4	4	2	4	0	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr10:103190136C>G	uc001kta.2	+	2	196	c.83C>G	c.(82-84)TCC>TGC	p.S28C	BTRC_uc001ksz.1_Intron|BTRC_uc001ktb.2_Intron|BTRC_uc001ktc.2_Missense_Mutation_p.S28C	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	28					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CTGGGCTGCTCCAGCCTGGCG	0.537													3	31					0	0	0	0	G	103190136	G	G	103190136	3	3	99	1	0	0	0	0	1	0	0	0	1574	855	30	2	89	2	BTRC	10	103190136	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	12091105	103190136	32344611	104	18997											
FGF8	2253	broad.mit.edu	37	chr10	103530279	103530279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccggcccttgcgggtgaagGccatgtaccagccctcgtac	6	7	13	15	3	0	1	0	1	0	0	1	1	0	1	5	3	4	2	5	3	3	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr10:103530279G>A	uc001ktp.1	-	6	679	c.509C>T	c.(508-510)GCC>GTC	p.A170V	FGF8_uc001ktq.1_Missense_Mutation_p.A181V|FGF8_uc001ktr.1_Missense_Mutation_p.A152V|FGF8_uc001kts.1_Missense_Mutation_p.A141V|FGF8_uc009xwr.1_Missense_Mutation_p.A77V	NM_033164	NP_149354	P55075	FGF8_HUMAN	fibroblast growth factor 8 isoform E precursor	170					bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		GCGGGTGAAGGCCATGTACCA	0.632													9	36					0	0	0	0	A	103530279	A	A	103530279	3	1	99	1	0	0	0	0	1	0	0	0	5890	1203	42	4	196	4	FGF8	10	103530279	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	340143	103530279	32004468	105	18998											
SYT9	143425	broad.mit.edu	37	chr11	7324466	7324466	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcaggagaacagtgaggaCttcctagatcctcccacgcc	11	6	11	13	1	0	3	0	1	0	2	3	6	3	4	4	2	2	1	4	2	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:7324466C>T	uc001mfe.2	+	2	579	c.342C>T	c.(340-342)GAC>GAT	p.D114D	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	114	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		ACAGTGAGGACTTCCTAGATC	0.577													15	49					0	0	0	0	T	7324466	T	T	7324466	2	4	99	1	0	0	0	0	0	0	0	1	15547	564	20	4		4	SYT9	11	7324466	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		7324466	127682050	106	18999											
SLC6A5	9152	broad.mit.edu	37	chr11	20658775	20658775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgagtttcccaagtacctaCgcacacacaagccagtgttt	12	9	7	13	2	0	0	0	0	0	0	1	1	1	0	3	0	3	4	3	0	4	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:20658775C>T	uc001mqd.2	+	12	2068	c.1795C>T	c.(1795-1797)CGC>TGC	p.R599C	SLC6A5_uc009yic.2_Missense_Mutation_p.R364C	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	599					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	CAAGTACCTACGCACACACAA	0.483													25	51					0	0	0	0	T	20658775	T	T	20658775	3	4	99	1	0	0	0	0	1	0	0	0	14751	536	19	1	1841	1	SLC6A5	11	20658775	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	13334309	20658775	114347741	107	19000											
LGR4	55366	broad.mit.edu	37	chr11	27389780	27389780	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacaaccaccttggctactGatggaaactgaaactgatcc	14	8	8	11	0	0	4	0	3	0	1	1	5	1	5	3	2	4	1	3	2	4	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:27389780G>A	uc001mrj.3	-	18	2975	c.2490C>T	c.(2488-2490)ATC>ATT	p.I830I	LGR4_uc001mrk.3_Silent_p.I806I	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	830	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						CTTGGCTACTGATGGAAACTG	0.448													29	142					0	0	0	0	A	27389780	A	A	27389780	2	1	99	1	0	0	0	0	0	0	0	1	8797	1280	45	2		2	LGR4	11	27389780	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	6731005	27389780	107616736	108	19001											
PACSIN3	29763	broad.mit.edu	37	chr11	47200778	47200778	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaccagcgcagatcctcttCgtcactggctgcctcaatgc	7	9	8	17	2	3	1	2	0	1	1	5	1	4	1	4	1	3	2	4	1	1	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:47200778C>T	uc001ndw.2	-	8	1170	c.832G>A	c.(832-834)GAA>AAA	p.E278K	ARFGAP2_uc001ndt.2_5'Flank|ARFGAP2_uc010rhb.1_5'Flank|ARFGAP2_uc001ndu.2_5'Flank|ARFGAP2_uc010rhc.1_5'Flank|ARFGAP2_uc010rhd.1_5'Flank|ARFGAP2_uc001ndv.1_5'Flank|PACSIN3_uc001ndx.2_Missense_Mutation_p.E278K|PACSIN3_uc001ndy.2_Missense_Mutation_p.E278K|PACSIN3_uc001ndz.2_RNA|PACSIN3_uc001nea.2_RNA	NM_016223	NP_057307	Q9UKS6	PACN3_HUMAN	protein kinase C and casein kinase substrate in	278					endocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis	cytoplasm|plasma membrane	cytoskeletal protein binding				0						AGATCCTCTTCGTCACTGGCT	0.612													51	109					0	0	0	0	T	47200778	T	T	47200778	3	4	99	1	0	0	0	0	1	0	0	0	11430	893	31	1	458	1	PACSIN3	11	47200778	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	19810998	47200778	87805738	109	19002											
UBE2L6	9246	broad.mit.edu	37	chr11	57319916	57319916	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattctgtgtcagcaggtcaGcgaggtccatccgcaggggc	7	8	15	11	2	3	0	2	0	1	0	5	2	5	0	2	4	2	2	2	4	0	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:57319916G>A	uc001nkn.1	-	4	473	c.377C>T	c.(376-378)GCT>GTT	p.A126V	UBE2L6_uc001nko.1_Missense_Mutation_p.A60V	NM_004223	NP_004214	O14933	UB2L6_HUMAN	ubiquitin-conjugating enzyme E2L 6 isoform 1	126					negative regulation of type I interferon production	cytosol	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						CAGCAGGTCAGCGAGGTCCAT	0.572													36	166					0	0	0	0	A	57319916	A	A	57319916	3	1	99	1	0	0	0	0	1	0	0	0	16932	971	34	4	88	4	UBE2L6	11	57319916	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	10119138	57319916	77686600	110	19003											
C11orf9	745	broad.mit.edu	37	chr11	61541579	61541579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagcccaagtacgtcaagaCgcccgagggcctcaagcccc	10	3	11	17	4	2	1	2	0	0	1	2	3	2	1	5	1	3	1	5	1	4	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:61541579C>T	uc001nsc.1	+	8	1352	c.1256C>T	c.(1255-1257)ACG>ATG	p.T419M	C11orf9_uc001nse.1_Missense_Mutation_p.T410M	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	419	NDT80.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						TACGTCAAGACGCCCGAGGGC	0.587													5	18					0	0	0	0	T	61541579	T	T	61541579	3	4	99	1	0	0	0	0	1	0	0	0	1677	536	19	1	1309	1	C11orf9	11	61541579	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	4221663	61541579	73464937	111	19004											
DKFZp761E198	91056	broad.mit.edu	37	chr11	65545479	65545480	+	Frame_Shift_Ins	INS	-	G	G																															ggcaggtggattgctacacaINSgtagctggtaggaggctggg																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:65545479_65545480insG	uc001ofo.3	-	1	2343_2344	c.2313_2314insC	c.(2311-2316)TACTGTfs	p.Y771fs		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	771_772							protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		ATTGCTACACAGTAGCTGGTAG	0.658													---	---	---								G	65545480	G	G	65545479	7	5	99	1	0	1	1	0	0	0	0	0	4565	188	7	0	155	0	DKFZp761E198	11	65545479	Frame_Shift_Ins	INS	-	TCGA-CQ-5334-01A-01D-1683-08	4003900	65545479	69461037	112	19005											
BACE1	23621	broad.mit.edu	37	chr11	117161343	117161343	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtaacagtcgtcttgggaCgtggccacatcttccactgg	7	12	11	11	2	2	0	0	0	2	0	4	1	3	1	2	3	1	1	2	3	1	4	rs75519595	by1000genomes	TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:117161343C>T	uc001pqz.2	-	8	1586	c.1125G>A	c.(1123-1125)ACG>ACA	p.T375T	BACE1_uc001pqw.2_Silent_p.T350T|BACE1_uc001pqx.2_Silent_p.T306T|BACE1_uc001pqy.2_Silent_p.T331T|BACE1_uc010rxg.1_Silent_p.T250T|BACE1_uc010rxh.1_Silent_p.T275T|BACE1_uc009yzo.1_Missense_Mutation_p.R43H|uc010rxi.1_5'Flank	NM_012104	NP_036236	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1 isoform A	375	Extracellular (Potential).				beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			ovary(1)	1	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		CGTCTTGGGACGTGGCCACAT	0.532													8	17					0	0	0	0	T	117161343	T	T	117161343	2	4	99	1	0	0	0	0	0	0	0	1	1283	523	19	1		1	BACE1	11	117161343	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	51615864	117161343	17845173	113	19006											
DDX6	1656	broad.mit.edu	37	chr11	118630664	118630664	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acactaagagggaaagtagcGgaatatagtaaaatctgcct	17	8	10	6	1	1	1	0	0	1	1	1	3	1	3	1	2	2	2	1	2	8	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:118630664G>A	uc001pub.2	-	8	1192	c.831C>T	c.(829-831)TCC>TCT	p.S277S	DDX6_uc001pua.2_5'Flank|DDX6_uc001puc.2_Silent_p.S277S	NM_004397	NP_004388	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	277	Helicase ATP-binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		GGAAAGTAGCGGAATATAGTA	0.383			T	IGH@	B-NHL								17	33					0	0	0	0	A	118630664	A	A	118630664	2	1	99	1	0	0	0	0	0	0	0	1	4394	1103	39	1		1	DDX6	11	118630664	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	1469321	118630664	16375852	114	19007											
ARHGAP32	9743	broad.mit.edu	37	chr11	128846491	128846491	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagagatgtaagagactcctCacttttagctgaacggaggg	12	9	13	7	1	1	3	1	1	0	2	2	7	2	4	1	2	2	2	1	2	3	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:128846491C>G	uc009zcp.2	-	19	2119	c.2119G>C	c.(2119-2121)GAG>CAG	p.E707Q	ARHGAP32_uc009zcq.1_Missense_Mutation_p.E667Q|ARHGAP32_uc009zco.2_5'UTR|ARHGAP32_uc001qez.2_Missense_Mutation_p.E358Q	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	707					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						AGAGACTCCTCACTTTTAGCT	0.363													17	77					0	0	0	0	G	128846491	G	G	128846491	3	3	99	1	0	0	0	0	1	0	0	0	881	835	29	2	4160	2	ARHGAP32	11	128846491	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	10215827	128846491	6160025	115	19008											
ACAD8	27034	broad.mit.edu	37	chr11	134128424	134128424	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcagcatgtgtgcctggatGattgatagcttcggaaatga	11	12	12	6	1	1	3	1	3	0	0	2	5	1	5	1	2	3	2	1	2	2	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr11:134128424G>A	uc001qhk.2	+	4	457	c.396G>A	c.(394-396)ATG>ATA	p.M132I	ACAD8_uc009zdc.2_Missense_Mutation_p.M34I|ACAD8_uc010sco.1_Missense_Mutation_p.M34I|ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Missense_Mutation_p.M55I|ACAD8_uc001qhl.2_Intron|ACAD8_uc010scr.1_Missense_Mutation_p.M94I|ACAD8_uc009zde.1_Missense_Mutation_p.M5I	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	132					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		GTGCCTGGATGATTGATAGCT	0.313													10	18					0	0	0	0	A	134128424	A	A	134128424	3	1	99	1	0	0	0	0	1	0	0	0	110	1290	45	2	410	2	ACAD8	11	134128424	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	5281933	134128424	878092	116	19009											
CD163L1	283316	broad.mit.edu	37	chr12	7526210	7526210	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagctctctgtttcagtttCactgtagagcctcaaggctg	8	13	9	11	0	4	1	3	0	1	1	5	1	4	1	1	1	2	5	1	1	2	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:7526210C>T	uc001qsy.2	-	14	3462	c.3436G>A	c.(3436-3438)GAA>AAA	p.E1146K	CD163L1_uc010sge.1_Missense_Mutation_p.E1156K	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1146	SRCR 11.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GTTTCAGTTTCACTGTAGAGC	0.458													26	179					0	0	0	0	T	7526210	T	T	7526210	3	4	99	1	0	0	0	0	1	0	0	0	2983	835	29	2	949	2	CD163L1	12	7526210	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		7526210	126325685	117	19010											
SLCO1B3	28234	broad.mit.edu	37	chr12	21015468	21015468	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acattgatgattttgcaaaaGaaggacattcttccttgtat	13	15	7	6	0	1	3	0	2	1	1	2	4	2	4	1	1	1	2	1	1	4	7			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:21015468G>C	uc001rek.2	+	6	730	c.604G>C	c.(604-606)GAA>CAA	p.E202Q	SLCO1B3_uc001rel.2_Missense_Mutation_p.E202Q|SLCO1B3_uc010sil.1_Missense_Mutation_p.E202Q|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.E27Q	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	202	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TTTTGCAAAAGAAGGACATTC	0.353													8	42					0	0	0	0	C	21015468	C	C	21015468	3	2	99	1	0	0	0	0	1	0	0	0	14788	943	33	2	622	2	SLCO1B3	12	21015468	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	13489258	21015468	112836427	118	19011											
CCDC91	55297	broad.mit.edu	37	chr12	28458663	28458663	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccattggctgcctctcttCtgatgccattatttcatcac	6	17	5	13	0	4	1	2	1	2	0	6	1	5	1	3	1	2	1	3	1	1	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:28458663C>G	uc001riq.2	+	3	207	c.191C>G	c.(190-192)TCT>TGT	p.S64C	CCDC91_uc001rio.2_Missense_Mutation_p.S34C|CCDC91_uc009zjk.2_RNA|CCDC91_uc001rip.1_Missense_Mutation_p.S64C|CCDC91_uc001rir.2_5'UTR|CCDC91_uc009zjl.2_5'Flank	NM_018318	NP_060788	Q7Z6B0	CCD91_HUMAN	GGA binding partner	64					protein transport	Golgi apparatus|membrane				central_nervous_system(1)	1	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					TGCCTCTCTTCTGATGCCATT	0.393													34	136					0	0	0	0	G	28458663	G	G	28458663	3	3	99	1	0	0	0	0	1	0	0	0	2883	913	32	2	201	2	CCDC91	12	28458663	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	7443195	28458663	105393232	119	19012											
TMTC1	83857	broad.mit.edu	37	chr12	29920863	29920863	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aataggatgtacagcaaaaaGcaatgccgttacaaaagcaa	20	6	8	7	1	0	0	0	0	0	0	0	1	0	1	1	1	6	5	1	1	10	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:29920863G>C	uc001rjb.2	-	2	598	c.124C>G	c.(124-126)CTT>GTT	p.L42V	TMTC1_uc001rjc.1_Missense_Mutation_p.L42V	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	150						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					ACAGCAAAAAGCAATGCCGTT	0.308													11	36					0	0	0	0	C	29920863	C	C	29920863	3	2	99	1	0	0	0	0	1	0	0	0	16326	971	34	4	2268	4	TMTC1	12	29920863	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	1462200	29920863	103931032	120	19013											
DGKA	1606	broad.mit.edu	37	chr12	56334131	56334131	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggtgcgaggaggctgtGagtccgggcgctgcgaccgc	4	7	20	10	5	0	1	0	1	0	0	1	4	1	2	2	4	2	2	2	4	0	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:56334131G>T	uc001sij.2	+	11	1096	c.832G>T	c.(832-834)GAG>TAG	p.E278*	DGKA_uc009zoc.1_Nonsense_Mutation_p.E278*|DGKA_uc001sih.1_Nonsense_Mutation_p.E166*|DGKA_uc001sii.1_Nonsense_Mutation_p.E136*|DGKA_uc009zod.1_Nonsense_Mutation_p.E197*|DGKA_uc009zoe.1_3'UTR|DGKA_uc001sik.2_Nonsense_Mutation_p.E278*|DGKA_uc001sil.2_Nonsense_Mutation_p.E278*|DGKA_uc001sim.2_Nonsense_Mutation_p.E278*|DGKA_uc001sin.2_Nonsense_Mutation_p.E278*|DGKA_uc009zof.2_5'UTR|DGKA_uc001sio.2_Nonsense_Mutation_p.E20*	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	278	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	AGGAGGCTGTGAGTCCGGGCG	0.597											OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	89					1.56452e-12	1.75257e-12	1	0	T	56334131	T	T	56334131	4	4	99	1	0	0	0	0	0	1	0	0	4487	1291	45	2	870	2	DGKA	12	56334131	Nonsense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	26413268	56334131	77517764	121	19014											
ERBB3	2065	broad.mit.edu	37	chr12	56486845	56486845	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caatttgacaaccattggagGcagaagcctctacaagtgag	14	8	10	9	0	1	3	0	2	1	1	1	4	1	4	2	2	3	1	2	2	5	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:56486845G>C	uc001sjh.2	+	11	1452	c.1259G>C	c.(1258-1260)GGC>GCC	p.G420A	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.G361A|ERBB3_uc009zok.2_5'Flank|ERBB3_uc001sjk.2_5'Flank|ERBB3_uc001sjj.1_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	420	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			ACCATTGGAGGCAGAAGCCTC	0.468													7	24					0	0	0	0	C	56486845	C	C	56486845	3	2	99	1	0	0	0	0	1	0	0	0	5232	1203	42	4	1432	4	ERBB3	12	56486845	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	152714	56486845	77365050	122	19015											
FGD6	55785	broad.mit.edu	37	chr12	95501371	95501371	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcgaggttgcatcactttccGagacagcttcatcagaattc	10	12	8	11	2	3	2	3	0	0	2	6	4	4	2	1	1	2	3	1	1	1	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:95501371G>C	uc001tdp.3	-	12	3525	c.3301C>G	c.(3301-3303)CGG>GGG	p.R1101G	FGD6_uc009zsx.2_Missense_Mutation_p.R234G|FGD6_uc001tdq.1_Missense_Mutation_p.R137G	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1101	PH 1.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						ATCACTTTCCGAGACAGCTTC	0.418													9	37					0	0	0	0	C	95501371	C	C	95501371	3	2	99	1	0	0	0	0	1	0	0	0	5869	1057	37	3	1031	3	FGD6	12	95501371	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	39014526	95501371	38350524	123	19016											
RIC8B	55188	broad.mit.edu	37	chr12	107236437	107236437	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatttgtccgttaacccatGaagaaacagcccaagaggca	14	8	8	11	1	1	3	1	1	0	2	2	3	2	3	3	1	3	2	3	1	4	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:107236437G>C	uc001tlx.2	+	5	1032	c.907G>C	c.(907-909)GAA>CAA	p.E303Q	RIC8B_uc001tlw.2_Missense_Mutation_p.E303Q|RIC8B_uc001tly.2_Missense_Mutation_p.E263Q|RIC8B_uc001tlz.2_RNA|RIC8B_uc009zur.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	303					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						GTTAACCCATGAAGAAACAGC	0.363													8	39					0	0	0	0	C	107236437	C	C	107236437	3	2	99	1	0	0	0	0	1	0	0	0	13421	1291	45	2	925	2	RIC8B	12	107236437	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	11735066	107236437	26615458	124	19017											
NCOR2	9612	broad.mit.edu	37	chr12	124839420	124839420	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgggcaggggcagccccatGgtgacagggcccaccggggc	7	3	18	13	1	0	1	0	1	0	0	0	1	0	1	4	7	1	2	4	7	0	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:124839420G>A	uc010tba.1	-	25	3588	c.3471C>T	c.(3469-3471)ACC>ACT	p.T1157T	NCOR2_uc010tay.1_Silent_p.T1156T|NCOR2_uc010taz.1_Silent_p.T1140T|NCOR2_uc010tbb.1_Silent_p.T1149T|NCOR2_uc010tbc.1_Silent_p.T1139T|NCOR2_uc001ugj.1_Silent_p.T1157T	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1157					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCAGCCCCATGGTGACAGGGC	0.672													11	48					0	0	0	0	A	124839420	A	A	124839420	2	1	99	1	0	0	0	0	0	0	0	1	10290	1335	47	4		4	NCOR2	12	124839420	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	17602983	124839420	9012475	125	19018											
TMEM132B	114795	broad.mit.edu	37	chr12	126139056	126139056	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agaaagaaattaaaaatgaaCctatgaattcttcgggccca	18	9	7	7	1	1	4	0	2	1	2	2	4	1	4	2	1	1	0	2	1	8	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:126139056C>T	uc001uhe.1	+	9	3045	c.3037C>T	c.(3037-3039)CCT>TCT	p.P1013S	TMEM132B_uc001uhf.1_Missense_Mutation_p.P525S	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	1013	Cytoplasmic (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TAAAAATGAACCTATGAATTC	0.463													5	26					0	0	0	0	T	126139056	T	T	126139056	3	4	99	1	0	0	0	0	1	0	0	0	16112	507	18	4	3071	4	TMEM132B	12	126139056	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	1299636	126139056	7712839	126	19019											
TMEM132D	121256	broad.mit.edu	37	chr12	130185047	130185047	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcccgtagctggcattgagGacaggcagcctcctggattt	7	9	14	11	1	0	1	0	1	0	0	1	3	1	3	3	5	2	4	3	5	1	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:130185047G>A	uc009zyl.1	-	2	604	c.276C>T	c.(274-276)GTC>GTT	p.V92V		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	92	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TGGCATTGAGGACAGGCAGCC	0.502													7	27					0	0	0	0	A	130185047	A	A	130185047	2	1	99	1	0	0	0	0	0	0	0	1	16113	1161	41	2		2	TMEM132D	12	130185047	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	4045991	130185047	3666848	127	19020											
RAN	5901	broad.mit.edu	37	chr12	131359130	131359133	+	Frame_Shift_Del	DEL	TTAC	-	-																															gtttgatgtaacatcgagagTtacttacaagaatgtgccta																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr12:131359130_131359133delTTAC	uc001uir.2	+	5	352_355	c.287_290delTTAC	c.(286-291)GTTACTfs	p.V96fs	RAN_uc010tbk.1_Frame_Shift_Del_p.V8fs|RAN_uc010tbl.1_Frame_Shift_Del_p.V8fs|RAN_uc001uis.2_Frame_Shift_Del_p.V116fs	NM_006325	NP_006316	P62826	RAN_HUMAN	ras-related nuclear protein	96_97					androgen receptor signaling pathway|cell division|DNA metabolic process|mitosis|mitotic spindle organization|positive regulation of transcription, DNA-dependent|protein export from nucleus|RNA export from nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|melanosome|nuclear pore|nucleoplasm	androgen receptor binding|chromatin binding|GTP binding|GTPase activity|transcription coactivator activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	Lung NSC(355;7.46e-07)|all_epithelial(31;7.36e-06)		OV - Ovarian serous cystadenocarcinoma(86;9.18e-49)|Epithelial(86;1.42e-45)|all cancers(50;6.28e-40)		ACATCGAGAGTTACTTACAAGAAT	0.407													---	---	---								-	131359133	-	-	131359130	7	5	99	1	0	1	0	1	0	0	0	0	13089	1725	60	0	301	0	RAN	12	131359130	Frame_Shift_Del	DEL	TTAC	TCGA-CQ-5334-01A-01D-1683-08	1174083	131359130	2492765	128	19021											
RASL11A	387496	broad.mit.edu	37	chr13	27845676	27845676	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagactatgaaccgaatacAggtgagaatactttcacgct	14	9	10	8	2	1	3	1	2	0	2	1	6	1	3	1	2	3	1	1	2	6	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr13:27845676A>G	uc001urd.1	+	2	798	c.180A>G	c.(178-180)ACA>ACG	p.T60T		NM_206827	NP_996563	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	60	Small GTPase-like.				positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(1)	1		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		AACCGAATACAGGTGAGAATA	0.418											OREG0022312	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	110					0	0	0	0	G	27845676	G	G	27845676	2	3	99	1	0	0	0	0	0	0	0	1	13146	202	7	5		5	RASL11A	13	27845676	Silent	SNP	A	TCGA-CQ-5334-01A-01D-1683-08		27845676	87324202	129	19022											
C13orf33	84935	broad.mit.edu	37	chr13	31495735	31495736	+	Frame_Shift_Ins	INS	-	A	A																															gtgaagaatttcttccccccINSaggaaatgaagtggttaatg																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr13:31495735_31495736insA	uc001uth.3	+	4	880_881	c.539_540insA	c.(538-540)CCAfs	p.P180fs	uc001utg.1_Intron	NM_032849	NP_116238	Q5VYS4	CM033_HUMAN	hypothetical protein LOC84935	180											0		Lung SC(185;0.0281)		all cancers(112;0.00914)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.0559)|GBM - Glioblastoma multiforme(144;0.244)		TTCTTCCCCCCAGGAAATGAAG	0.361													---	---	---								A	31495736	A	A	31495735	7	5	99	1	0	1	1	0	0	0	0	0	1733	594	21	0	553	0	C13orf33	13	31495735	Frame_Shift_Ins	INS	-	TCGA-CQ-5334-01A-01D-1683-08	3650059	31495735	83674143	130	19023											
N4BP2L1	90634	broad.mit.edu	37	chr13	32977300	32977300	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcataccgttctttcattcGgtggattttttctcttgaga	6	20	7	8	2	4	1	2	1	2	1	6	3	4	2	1	2	1	1	1	2	1	9			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr13:32977300G>A	uc001uuc.2	-	5	607	c.511C>T	c.(511-513)CGA>TGA	p.R171*	N4BP2L1_uc001uud.2_Missense_Mutation_p.P168L|N4BP2L1_uc010tdy.1_Nonsense_Mutation_p.R171*	NM_052818	NP_438169	Q5TBK1	N42L1_HUMAN	NEDD4 binding protein 2-like 1 isoform 1	171					cell killing		ATP binding			ovary(1)	1		Lung SC(185;0.0262)		all cancers(112;6.3e-06)|Epithelial(112;3.51e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00607)|BRCA - Breast invasive adenocarcinoma(63;0.0171)		TCTTTCATTCGGTGGATTTTT	0.363													18	65					0	0	0	0	A	32977300	A	A	32977300	4	1	99	1	0	0	0	0	0	1	0	0	10164	1125	39	1	224	1	N4BP2L1	13	32977300	Nonsense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	1481565	32977300	82192578	131	19024											
CCNA1	8900	broad.mit.edu	37	chr13	37007189	37007189	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcagcccgtggagtctgAagcaatgcactgcagcaacc	11	5	12	13	1	1	1	0	1	1	0	1	2	1	2	2	1	7	6	2	1	3	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr13:37007189A>G	uc001uvr.3	+	2	478	c.128A>G	c.(127-129)GAA>GGA	p.E43G	CCNA1_uc010teo.1_5'UTR|CCNA1_uc010abq.2_5'UTR|CCNA1_uc010abp.2_5'UTR|CCNA1_uc001uvs.3_Missense_Mutation_p.E42G|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	43				EAMHC -> SS (in Ref. 2; AAV38384).	cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		GTGGAGTCTGAAGCAATGCAC	0.587													21	87					0	0	0	0	G	37007189	G	G	37007189	3	3	99	1	0	0	0	0	1	0	0	0	2924	246	9	5	134	5	CCNA1	13	37007189	Missense_Mutation	SNP	A	TCGA-CQ-5334-01A-01D-1683-08	4029889	37007189	78162689	132	19025											
LMO7	4008	broad.mit.edu	37	chr13	76287355	76287355	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgaaacaaaagattttcGagcctctctagaaaatggtg	14	13	8	6	1	1	3	0	1	1	2	3	4	1	3	1	1	2	0	1	1	6	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr13:76287355G>T	uc010thv.1	+	3	1523	c.263G>T	c.(262-264)CGA>CTA	p.R88L	LMO7_uc001vjt.1_Missense_Mutation_p.R36L	NM_005358	NP_005349	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 1	88	CH.					cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AAAGATTTTCGAGCCTCTCTA	0.343													4	31					2.56e-06	2.73615e-06	1	0	T	76287355	T	T	76287355	3	4	99	1	0	0	0	0	1	0	0	0	8897	1058	37	3	273	3	LMO7	13	76287355	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	39280166	76287355	38882523	133	19026											
MYO16	23026	broad.mit.edu	37	chr13	109496715	109496715	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctggtgttaccaattgcCaagcaagacagtttgttgga	10	11	10	10	0	0	1	0	0	0	1	0	2	0	2	4	2	3	4	4	2	4	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr13:109496715C>T	uc001vqt.1	+	10	1182	c.1056C>T	c.(1054-1056)GCC>GCT	p.A352A	MYO16_uc010agk.1_Silent_p.A374A|MYO16_uc001vqu.1_Silent_p.A152A	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	352					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TACCAATTGCCAAGCAAGACA	0.378													6	42					0	0	0	0	T	109496715	T	T	109496715	2	4	99	1	0	0	0	0	0	0	0	1	10117	581	21	4		4	MYO16	13	109496715	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	33209360	109496715	5673163	134	19027											
DHRS2	10202	broad.mit.edu	37	chr14	24108117	24108117	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctaccagggctggtttcatcCctgtgctaggctttctgtga	5	14	11	11	0	2	1	1	1	1	0	3	1	3	1	2	3	2	4	2	3	2	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr14:24108117C>T	uc001wkt.3	+	2	491	c.44C>T	c.(43-45)CCC>CTC	p.P15L	DHRS2_uc010aku.1_Missense_Mutation_p.P15L|DHRS2_uc001wku.3_Missense_Mutation_p.P15L|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Missense_Mutation_p.P15L	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	Error:Variant_position_missing_in_Q13268_after_alignment					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		TGGTTTCATCCCTGTGCTAGG	0.582													43	74					0	0	0	0	T	24108117	T	T	24108117	3	4	99	1	0	0	0	0	1	0	0	0	4512	623	22	4	46	4	DHRS2	14	24108117	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		24108117	83241423	135	19028											
HECTD1	25831	broad.mit.edu	37	chr14	31588931	31588931	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtacctgggggtggtatttCtagatcagttgtctgctgga	6	15	14	6	0	3	1	1	0	2	1	3	2	3	2	1	4	2	4	1	4	3	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr14:31588931C>G	uc001wrc.1	-	29	5869	c.5380G>C	c.(5380-5382)GAA>CAA	p.E1794Q	HECTD1_uc001wra.1_5'UTR|HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Missense_Mutation_p.E1262Q	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1794					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GGTGGTATTTCTAGATCAGTT	0.378													19	51					0	0	0	0	G	31588931	G	G	31588931	3	3	99	1	0	0	0	0	1	0	0	0	7078	922	32	2	2512	2	HECTD1	14	31588931	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	7480814	31588931	75760609	136	19029											
SYNE2	23224	broad.mit.edu	37	chr14	64560106	64560106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaatgggatgaagaaataGaaaatttgaaacagatctta	20	10	9	2	0	1	6	0	3	1	3	1	7	1	7	0	1	1	0	0	1	8	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr14:64560106G>A	uc001xgm.2	+	61	12246	c.12016G>A	c.(12016-12018)GAA>AAA	p.E4006K	SYNE2_uc001xgl.2_Missense_Mutation_p.E4006K|SYNE2_uc010apy.2_Missense_Mutation_p.E391K|SYNE2_uc010apx.1_Missense_Mutation_p.E398K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4006	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGAAGAAATAGAAAATTTGAA	0.343													32	60					0	0	0	0	A	64560106	A	A	64560106	3	1	99	1	0	0	0	0	1	0	0	0	15512	943	33	2	12254	2	SYNE2	14	64560106	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	32971175	64560106	42789434	137	19030											
EIF2S1	1965	broad.mit.edu	37	chr14	67850070	67850070	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acagatgagactgaacttgcGaggcagatggagaggcttga	13	7	15	6	1	0	6	0	3	0	4	0	9	0	6	0	3	2	2	0	3	1	2	rs55950335		TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr14:67850070G>A	uc001xjg.2	+	8	1002	c.861G>A	c.(859-861)GCG>GCA	p.A287A		NM_004094	NP_004085	P05198	IF2A_HUMAN	eukaryotic translation initiation factor 2,	287						cytosol|eukaryotic translation initiation factor 2 complex|polysome|stress granule	protein binding|ribosome binding|translation initiation factor activity			ovary(1)	1				all cancers(60;0.000683)|OV - Ovarian serous cystadenocarcinoma(108;0.00579)|BRCA - Breast invasive adenocarcinoma(234;0.00937)		CTGAACTTGCGAGGCAGATGG	0.398													4	35					0	0	0	0	A	67850070	A	A	67850070	2	1	99	1	0	0	0	0	0	0	0	1	5031	1045	37	1		1	EIF2S1	14	67850070	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	3289964	67850070	39499470	138	19031											
AHSA1	10598	broad.mit.edu	37	chr14	77930945	77930945	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattttatcttttcagagttCacccagggcatgatcttacc	10	15	6	10	0	4	2	2	1	2	1	4	2	4	2	2	1	1	2	2	1	3	6			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr14:77930945C>A	uc001xtw.2	+	5	637	c.477C>A	c.(475-477)TTC>TTA	p.F159L	AHSA1_uc010tvk.1_Missense_Mutation_p.F159L	NM_012111	NP_036243	O95433	AHSA1_HUMAN	activator of heat shock 90kDa protein ATPase	159					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		TTTCAGAGTTCACCCAGGGCA	0.458													13	25					5.50884e-06	5.80796e-06	1	0	A	77930945	A	A	77930945	3	1	99	1	0	0	0	0	1	0	0	0	418	825	29	2	495	2	AHSA1	14	77930945	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	10080875	77930945	29418595	139	19032											
CLMN	79789	broad.mit.edu	37	chr14	95677035	95677035	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actgctaccttctggctccaGgagcctggggatgtgcaggg	6	9	15	11	0	1	0	0	0	1	0	2	2	2	2	3	5	4	3	3	5	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr14:95677035G>A	uc001yef.2	-	7	906	c.790C>T	c.(790-792)CTG>TTG	p.L264L		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	264	Actin-binding.|CH 2.					integral to membrane	actin binding				0				Epithelial(152;0.193)		TCTGGCTCCAGGAGCCTGGGG	0.363													7	85					0	0	0	0	A	95677035	A	A	95677035	2	1	99	1	0	0	0	0	0	0	0	1	3557	991	35	4		4	CLMN	14	95677035	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	17746090	95677035	11672505	140	19033											
EIF5	1983	broad.mit.edu	37	chr14	103802212	103802212	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccaaaatgtctgtcaatgtCaaccgcagcgtgtcagacca	12	8	9	12	2	4	1	3	0	1	1	4	1	4	1	3	0	2	1	3	0	4	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr14:103802212C>G	uc001ymq.2	+	3	537	c.15C>G	c.(13-15)GTC>GTG	p.V5V	EIF5_uc001ymr.2_Silent_p.V5V|EIF5_uc001yms.2_Silent_p.V5V|EIF5_uc001ymt.2_Silent_p.V5V|EIF5_uc001ymu.2_Silent_p.V5V|SNORA28_uc001ymv.1_5'Flank	NM_001969	NP_001960	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	5					regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			pancreas(1)|breast(1)|skin(1)	3		Melanoma(154;0.155)	Epithelial(46;0.182)			CTGTCAATGTCAACCGCAGCG	0.403													31	102					0	0	0	0	G	103802212	G	G	103802212	2	3	99	1	0	0	0	0	0	0	0	1	5064	813	29	2		2	EIF5	14	103802212	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	8125177	103802212	3547328	141	19034											
PACS2	23241	broad.mit.edu	37	chr14	105849196	105849196	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccgtggtgtgcacgtgctCtcctgcggacgtccaggcgg	3	8	15	15	5	1	0	0	0	1	0	3	1	2	1	4	4	3	2	4	4	0	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr14:105849196C>T	uc001yqt.2	+	15	1734	c.1559C>T	c.(1558-1560)TCT>TTT	p.S520F	PACS2_uc001yqs.2_Missense_Mutation_p.S445F|PACS2_uc001yqv.2_Missense_Mutation_p.S524F|PACS2_uc001yqu.2_Missense_Mutation_p.S524F	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	520					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		TGCACGTGCTCTCCTGCGGAC	0.637													5	17					0	0	0	0	T	105849196	T	T	105849196	3	4	99	1	0	0	0	0	1	0	0	0	11427	913	32	2	1629	2	PACS2	14	105849196	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	2046984	105849196	1500344	142	19035											
MKRN3	7681	broad.mit.edu	37	chr15	23811463	23811463	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggctcggctgctgaaaggggTttctttgaagccgagagaga	9	9	16	7	2	1	4	0	2	1	2	2	6	1	4	1	4	2	4	1	4	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr15:23811463T>G	uc001ywh.3	+	1	1010	c.534T>G	c.(532-534)GGT>GGG	p.G178G	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Silent_p.G178G	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	178						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CTGAAAGGGGTTTCTTTGAAG	0.612													4	22					0	0	0	0	G	23811463	G	G	23811463	2	3	99	1	0	0	0	0	0	0	0	1	9661	1712	60	5		5	MKRN3	15	23811463	Silent	SNP	T	TCGA-CQ-5334-01A-01D-1683-08		23811463	78719929	143	19036											
PGBD4	161779	broad.mit.edu	37	chr15	34395158	34395158	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggtccgaaaggattttcGcgaatggataaatggaaaga	14	8	13	6	4	0	1	0	0	0	1	2	6	1	4	2	4	0	0	2	4	5	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr15:34395158G>A	uc001zho.2	+	1	885	c.426G>A	c.(424-426)TCG>TCA	p.S142S	C15orf24_uc001zhm.2_5'Flank|C15orf24_uc001zhn.2_5'Flank	NM_152595	NP_689808	Q96DM1	PGBD4_HUMAN	piggyBac transposable element derived 4	142											0		all_lung(180;1.76e-08)		all cancers(64;1.22e-17)|GBM - Glioblastoma multiforme(113;1.78e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0242)		AAGGATTTTCGCGAATGGATA	0.413													18	61					0	0	0	0	A	34395158	A	A	34395158	2	1	99	1	0	0	0	0	0	0	0	1	11838	1074	38	1		1	PGBD4	15	34395158	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	10583695	34395158	68136234	144	19037											
MAPK6	5597	broad.mit.edu	37	chr15	52356502	52356502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagaaaaatctgataagaaaGgcaaatcaaaatgtgaaagg	23	6	9	3	0	2	4	1	2	1	2	2	4	2	4	0	2	0	1	0	2	9	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr15:52356502G>A	uc002abp.2	+	6	2265	c.1471G>A	c.(1471-1473)GGC>AGC	p.G491S		NM_002748	NP_002739	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	491					cell cycle		ATP binding|MAP kinase activity			lung(3)|ovary(1)	4				all cancers(107;0.0028)		TGATAAGAAAGGCAAATCAAA	0.383													5	21					0	0	0	0	A	52356502	A	A	52356502	3	1	99	1	0	0	0	0	1	0	0	0	9334	1000	35	4	1489	4	MAPK6	15	52356502	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	17961344	52356502	50174890	145	19038											
ITGA11	22801	broad.mit.edu	37	chr15	68695271	68695271	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcaccacttattgccactGatgtcgtgctgctgcactgt	7	13	8	13	1	1	1	1	1	0	0	2	1	1	1	2	0	4	3	2	0	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr15:68695271G>C	uc002ari.2	-	2	237	c.150C>G	c.(148-150)ATC>ATG	p.I50M	ITGA11_uc010bib.2_Missense_Mutation_p.I50M	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	50	FG-GAP 1.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	TATTGCCACTGATGTCGTGCT	0.632													4	11					0	0	0	0	C	68695271	C	C	68695271	3	2	99	1	0	0	0	0	1	0	0	0	7913	1280	45	2	3532	2	ITGA11	15	68695271	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	16338769	68695271	33836121	146	19039											
PAQR5	54852	broad.mit.edu	37	chr15	69689821	69689821	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttaggtttcttgaaatccAgaagcccagactctgtaagg	12	12	9	8	0	2	3	0	1	2	2	3	3	3	3	2	2	1	2	2	2	4	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr15:69689821A>G	uc002arz.2	+	7	905	c.527A>G	c.(526-528)CAG>CGG	p.Q176R	PAQR5_uc002asa.2_Missense_Mutation_p.Q176R	NM_017705	NP_060175	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	176	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			ovary(2)	2						CTTGAAATCCAGAAGCCCAGA	0.507													8	62					0	0	0	0	G	69689821	G	G	69689821	3	3	99	1	0	0	0	0	1	0	0	0	11492	188	7	5	545	5	PAQR5	15	69689821	Missense_Mutation	SNP	A	TCGA-CQ-5334-01A-01D-1683-08	994550	69689821	32841571	147	19040											
ACAN	176	broad.mit.edu	37	chr15	89400924	89400924	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccagtgagctggacattaGtgggagagctagtggactcc	9	9	14	9	0	0	2	0	1	0	1	2	5	2	4	2	3	2	2	2	3	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr15:89400924G>A	uc010upo.1	+	12	5482	c.5108G>A	c.(5107-5109)AGT>AAT	p.S1703N	ACAN_uc010upp.1_Missense_Mutation_p.S1703N|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1703					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGGACATTAGTGGGAGAGCT	0.537													5	172					0	0	0	0	A	89400924	A	A	89400924	3	1	99	1	0	0	0	0	1	0	0	0	117	1029	36	4	5150	4	ACAN	15	89400924	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	19711103	89400924	13130468	148	19041											
CRTC3	64784	broad.mit.edu	37	chr15	91181798	91181798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccctcctgcagcagcccCgcgcccctgaggcccctgcc	4	4	10	23	2	0	1	0	1	0	0	1	1	1	1	10	1	5	2	10	1	0	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr15:91181798C>T	uc002bpp.2	+	12	1493	c.1387C>T	c.(1387-1389)CGC>TGC	p.R463C	CRTC3_uc002bpo.2_Missense_Mutation_p.R463C	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	463					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			GCAGCAGCCCCGCGCCCCTGA	0.672			T	MAML2	salivary gland mucoepidermoid								15	56					0	0	0	0	T	91181798	T	T	91181798	3	4	99	1	0	0	0	0	1	0	0	0	3916	652	23	1	1433	1	CRTC3	15	91181798	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	1780874	91181798	11349594	149	19042											
IGF1R	3480	broad.mit.edu	37	chr15	99251204	99251204	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtgtccaataactacattGtggggaataagcccccaaag	13	8	10	10	1	0	0	0	0	0	0	1	1	1	1	3	3	3	0	3	3	6	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr15:99251204G>T	uc002bul.2	+	2	558	c.508G>T	c.(508-510)GTG>TTG	p.V170L	IGF1R_uc010urq.1_Missense_Mutation_p.V170L|IGF1R_uc010bon.2_Missense_Mutation_p.V170L	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	170					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TAACTACATTGTGGGGAATAA	0.517													9	95					7.48243e-07	8.03413e-07	1	0	T	99251204	T	T	99251204	3	4	99	1	0	0	0	0	1	0	0	0	7610	1377	48	4	514	4	IGF1R	15	99251204	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	8069406	99251204	3280188	150	19043											
C16orf90	646174	broad.mit.edu	37	chr16	3546141	3546141	+	5'Flank	DEL	A	-	-																															gcagagcgagactccgtctcAaaaaaaaaaaaaagttaaac																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:3546141delA	uc002cvi.2	-							NM_001080524	NP_001073993	A8MZG2	CP090_HUMAN	hypothetical protein LOC646174												0						actccgtctcaaaaaaaaaaa	0.234													---	---	---								-	3546141	-	-	3546141	6	5	99	0	1	1	0	1	0	0	0	0	1849	145	5	0		0	C16orf90	16	3546141	5'Flank	DEL	A	TCGA-CQ-5334-01A-01D-1683-08		3546141	86808612	151	19044											
UBN1	29855	broad.mit.edu	37	chr16	4909145	4909145	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttcattaaagaaaagaaGaaaaaatctccaaaggttag	21	8	7	5	0	2	3	1	0	1	3	3	4	2	3	1	1	0	1	1	1	10	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:4909145G>C	uc002cyb.2	+	5	891	c.552G>C	c.(550-552)AAG>AAC	p.K184N	UBN1_uc010uxw.1_Missense_Mutation_p.K184N|UBN1_uc002cyc.2_Missense_Mutation_p.K184N	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	184	Lys-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						AAGAAAAGAAGAAAAAATCTC	0.393													18	43					0	0	0	0	C	4909145	C	C	4909145	3	2	99	1	0	0	0	0	1	0	0	0	16960	933	33	2	566	2	UBN1	16	4909145	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	1363004	4909145	85445608	152	19045											
OTOA	146183	broad.mit.edu	37	chr16	21698871	21698871	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccctggagtgtgtggagatCctgggcaaggtgctgagggg	6	9	19	7	0	0	2	0	1	0	1	2	4	2	3	2	6	1	2	2	6	1	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:21698871C>T	uc002djh.2	+	7	538	c.537C>T	c.(535-537)ATC>ATT	p.I179I	uc002diq.3_Intron|OTOA_uc010vbj.1_Silent_p.I100I	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	179					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		GTGTGGAGATCCTGGGCAAGG	0.592													9	43					0	0	0	0	T	21698871	T	T	21698871	2	4	99	1	0	0	0	0	0	0	0	1	11356	845	30	2		2	OTOA	16	21698871	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	16789726	21698871	68655882	153	19046											
PPP4C	5531	broad.mit.edu	37	chr16	30093814	30093814	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgttccccaggtgtgcggcGacatccatggacaattctat	8	11	10	12	2	1	0	0	0	1	0	3	2	3	1	3	3	1	1	3	3	2	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:30093814G>A	uc002dwe.2	+	4	304	c.160G>A	c.(160-162)GAC>AAC	p.D54N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|PPP4C_uc002dwf.2_Missense_Mutation_p.D54N|PPP4C_uc002dwg.2_RNA|PPP4C_uc002dwh.2_5'UTR	NM_002720	NP_002711	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	54		Iron (By similarity).			microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			skin(1)	1						GGTGTGCGGCGACATCCATGG	0.522													4	45					0	0	0	0	A	30093814	A	A	30093814	3	1	99	1	0	0	0	0	1	0	0	0	12462	1058	37	1	170	1	PPP4C	16	30093814	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	8394943	30093814	60260939	154	19047											
NOD2	64127	broad.mit.edu	37	chr16	50745595	50745595	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggtgcgtgccaaaggtgtCgtgccagggagtacggcgcc	6	7	17	11	4	0	0	0	0	0	0	1	1	0	1	3	4	4	1	3	4	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:50745595C>T	uc002egm.1	+	4	1878	c.1773C>T	c.(1771-1773)GTC>GTT	p.V591V	NOD2_uc010cbk.1_Silent_p.V564V|NOD2_uc002egl.1_Silent_p.V369V|NOD2_uc010cbl.1_Silent_p.V369V|NOD2_uc010cbm.1_Silent_p.V369V|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	591	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CCAAAGGTGTCGTGCCAGGGA	0.577													5	21					0	0	0	0	T	50745595	T	T	50745595	2	4	99	1	0	0	0	0	0	0	0	1	10571	871	31	1		1	NOD2	16	50745595	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	20651781	50745595	39609158	155	19048											
CETP	1071	broad.mit.edu	37	chr16	57015105	57015105	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccaggcctcctattctaaGaaaaagctcttcttaagcct	11	12	6	12	0	3	1	0	0	3	1	5	1	5	1	4	1	2	1	4	1	5	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:57015105G>C	uc002eki.2	+	12	1239	c.1182G>C	c.(1180-1182)AAG>AAC	p.K394N	CETP_uc002ekj.2_Missense_Mutation_p.K334N	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	394					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						CCTATTCTAAGAAAAAGCTCT	0.537													21	65					0	0	0	0	C	57015105	C	C	57015105	3	2	99	1	0	0	0	0	1	0	0	0	3292	933	33	2	1228	2	CETP	16	57015105	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	6269510	57015105	33339648	156	19049											
CES2	8824	broad.mit.edu	37	chr16	66973244	66973244	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacgccggcccatagccatGaaggctctaacctgccggtg	9	6	11	15	3	1	1	0	1	1	0	1	1	1	1	5	3	3	1	5	3	3	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:66973244G>C	uc002eqr.2	+	3	1598	c.598G>C	c.(598-600)GAA>CAA	p.E200Q	CES2_uc002eqq.2_Missense_Mutation_p.E200Q|CES2_uc002eqs.2_Missense_Mutation_p.E43Q	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	136					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CCATAGCCATGAAGGCTCTAA	0.542													25	88					0	0	0	0	C	66973244	C	C	66973244	3	2	99	1	0	0	0	0	1	0	0	0	3285	1291	45	2	608	2	CES2	16	66973244	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	9958139	66973244	23381509	157	19050											
LRRC36	55282	broad.mit.edu	37	chr16	67418858	67418858	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaagcgctcctgcctcctGagaagggtcatcatctgggg	8	8	14	11	1	3	1	2	1	1	1	5	3	5	2	3	4	2	1	3	4	2	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:67418858G>A	uc002esv.2	+	14	2150	c.2131G>A	c.(2131-2133)GAG>AAG	p.E711K	LRRC36_uc002esw.2_RNA|LRRC36_uc002esx.2_Missense_Mutation_p.E590K|LRRC36_uc010vjk.1_Missense_Mutation_p.E486K|LRRC36_uc010vjl.1_Missense_Mutation_p.E183K|LRRC36_uc002esy.2_Missense_Mutation_p.E221K	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	711											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		CCTGCCTCCTGAGAAGGGTCA	0.517													13	44					0	0	0	0	A	67418858	A	A	67418858	3	1	99	1	0	0	0	0	1	0	0	0	9040	1291	45	2	2213	2	LRRC36	16	67418858	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	445614	67418858	22935895	158	19051											
CTCF	10664	broad.mit.edu	37	chr16	67650751	67650751	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccacgagaagccattcaaGtgttccatgtgcgattacgc	11	9	9	12	3	1	1	1	0	0	1	2	3	2	1	3	0	3	1	3	0	3	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:67650751G>A	uc002etl.2	+	5	1346	c.1056G>A	c.(1054-1056)AAG>AAA	p.K352K	CTCF_uc010cek.2_Silent_p.K24K	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	352	C2H2-type 4.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		AGCCATTCAAGTGTTCCATGT	0.463													16	181					0	0	0	0	A	67650751	A	A	67650751	2	1	99	1	0	0	0	0	0	0	0	1	4017	1020	36	4		4	CTCF	16	67650751	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	231893	67650751	22704002	159	19052											
CTCF	10664	broad.mit.edu	37	chr16	67655479	67655479	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtgacacagtcatagccCgaaaaagtgatttgggtaag	14	9	11	7	1	1	2	1	2	0	0	1	3	1	2	1	1	1	1	1	1	4	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:67655479C>T	uc002etl.2	+	7	1632	c.1342C>T	c.(1342-1344)CGA>TGA	p.R448*	CTCF_uc010cek.2_Nonsense_Mutation_p.R120*	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	448	C2H2-type 7.		R -> Q (in a Wilms' tumor).		chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		AGTCATAGCCCGAAAAAGTGA	0.368													5	25					0	0	0	0	T	67655479	T	T	67655479	4	4	99	1	0	0	0	0	0	1	0	0	4017	644	23	1	1360	1	CTCF	16	67655479	Nonsense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	4728	67655479	22699274	160	19053											
SMPD3	55512	broad.mit.edu	37	chr16	68405851	68405851	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagaagagaaagccgagaaaCgcaaagggcagcgaggccac	17	0	14	10	3	0	3	0	0	0	3	0	6	0	3	2	2	3	2	2	2	4	0	rs147838351		TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:68405851C>T	uc002ewa.2	-	3	656	c.234G>A	c.(232-234)GCG>GCA	p.A78A	SMPD3_uc010cfe.2_Silent_p.A78A|SMPD3_uc010vlh.1_Silent_p.A78A	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	78	Helical; (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	AGCCGAGAAACGCAAAGGGCA	0.672													4	14					0	0	0	0	T	68405851	T	T	68405851	2	4	99	1	0	0	0	0	0	0	0	1	14870	523	19	1		1	SMPD3	16	68405851	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	750372	68405851	21948902	161	19054											
TMED6	146456	broad.mit.edu	37	chr16	69381705	69381705	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttacctcaattgcatccaGagtatcattcagttgttttc	9	16	5	11	0	3	1	3	0	0	1	5	1	4	1	3	0	2	4	3	0	3	7	rs117823350	byFrequency	TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:69381705G>C	uc002exc.1	-	3	508	c.475C>G	c.(475-477)CTG>GTG	p.L159V		NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain	159	Lumenal (Potential).				transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1						ATTGCATCCAGAGTATCATTC	0.413													28	149					0	0	0	0	C	69381705	C	C	69381705	3	2	99	1	0	0	0	0	1	0	0	0	16074	933	33	2	255	2	TMED6	16	69381705	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	975854	69381705	20973048	162	19055											
TMED6	146456	broad.mit.edu	37	chr16	69383442	69383442	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagacctgtctcttgggtaGagaagttaatctggccccga	10	10	11	10	1	2	2	0	0	2	2	3	4	2	2	3	2	0	2	3	2	3	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:69383442G>C	uc002exc.1	-	2	359	c.326C>G	c.(325-327)TCT>TGT	p.S109C		NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain	109	Lumenal (Potential).|GOLD.				transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1						CTCTTGGGTAGAGAAGTTAAT	0.443													33	137					0	0	0	0	C	69383442	C	C	69383442	3	2	99	1	0	0	0	0	1	0	0	0	16074	942	33	2	408	2	TMED6	16	69383442	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	1737	69383442	20971311	163	19056											
ADAMTS18	170692	broad.mit.edu	37	chr16	77465453	77465453	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccgttgtgcaaaatgtcGtgtgaaatatatgacccggc	10	11	11	9	3	0	2	0	2	0	0	1	2	0	2	2	1	2	2	2	1	5	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:77465453G>A	uc002ffc.3	-	3	653	c.234C>T	c.(232-234)CAC>CAT	p.H78H	ADAMTS18_uc002ffe.1_Translation_Start_Site|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	78					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GCAAAATGTCGTGTGAAATAT	0.488													16	249					0	0	0	0	A	77465453	A	A	77465453	2	1	99	1	0	0	0	0	0	0	0	1	263	1136	40	1		1	ADAMTS18	16	77465453	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	8082011	77465453	12889300	164	19057											
SLC7A5	8140	broad.mit.edu	37	chr16	87874057	87874057	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaggggttgatcatttcctCtgtgacgaaattcaagtaat	11	14	10	6	1	3	2	2	2	1	0	4	3	4	2	1	2	0	3	1	2	4	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr16:87874057C>T	uc002fkm.2	-	4	865	c.793G>A	c.(793-795)GAG>AAG	p.E265K		NM_003486	NP_003477	Q01650	LAT1_HUMAN	solute carrier family 7 (cationic amino acid	265					blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding				0				BRCA - Breast invasive adenocarcinoma(80;0.049)		ATCATTTCCTCTGTGACGAAA	0.423													10	66					0	0	0	0	T	87874057	T	T	87874057	3	4	99	1	0	0	0	0	1	0	0	0	14764	922	32	2	758	2	SLC7A5	16	87874057	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	10408604	87874057	2480696	165	19058											
RABEP1	9135	broad.mit.edu	37	chr17	5264712	5264712	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatctgctggaaacctggaCgagtcagattttggaccact	12	10	10	9	1	2	1	1	0	1	1	2	5	2	4	2	3	2	1	2	3	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:5264712C>A	uc002gbm.3	+	9	1529	c.1305C>A	c.(1303-1305)GAC>GAA	p.D435E	RABEP1_uc010clc.1_Missense_Mutation_p.D428E|RABEP1_uc010cld.1_Missense_Mutation_p.D392E|RABEP1_uc010vsw.1_Missense_Mutation_p.D392E|RABEP1_uc002gbl.3_Missense_Mutation_p.D435E|NUP88_uc002gbn.2_RNA	NM_004703	NP_004694	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	435					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2						GAAACCTGGACGAGTCAGATT	0.468													8	45					5.18039e-06	5.48651e-06	1	0	A	5264712	A	A	5264712	3	1	99	1	0	0	0	0	1	0	0	0	13026	535	19	3	1339	3	RABEP1	17	5264712	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		5264712	75930498	166	19059											
TP53	7157	broad.mit.edu	37	chr17	7578433	7578433	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacctccgtcatgtgctgtGactgcttgtagatggccatg	7	12	11	11	1	1	2	1	1	0	1	2	2	2	2	3	1	3	3	3	1	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:7578433G>C	uc002gim.2	-	5	691	c.497C>G	c.(496-498)TCA>TGA	p.S166*	TP53_uc002gig.1_Nonsense_Mutation_p.S166*|TP53_uc002gih.2_Nonsense_Mutation_p.S166*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.S34*|TP53_uc010cng.1_Nonsense_Mutation_p.S34*|TP53_uc002gii.1_Nonsense_Mutation_p.S34*|TP53_uc010cnh.1_Nonsense_Mutation_p.S166*|TP53_uc010cni.1_Nonsense_Mutation_p.S166*|TP53_uc002gij.2_Nonsense_Mutation_p.S166*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.S73*|TP53_uc002gio.2_Nonsense_Mutation_p.S34*|TP53_uc010vug.1_Nonsense_Mutation_p.S127*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	166	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		S -> T (in sporadic cancers; somatic mutation).|S -> L (in sporadic cancers; somatic mutation).|S -> A (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> G (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S166*(19)|p.0?(7)|p.S166P(5)|p.S166L(4)|p.Q167fs*14(4)|p.S166A(2)|p.S166fs*15(2)|p.S166S(2)|p.K164fs*3(2)|p.V157_C176del20(1)|p.Y163fs*1(1)|p.P151_V173del23(1)|p.K164_P219del(1)|p.S166T(1)|p.Q165_S166insYKQ(1)|p.Q165_M169delQSQHM(1)|p.Y163fs*14(1)|p.S149fs*72(1)|p.A159_Q167delAMAIYKQSQ(1)|p.S166G(1)|p.Q165_S166insXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGTGCTGTGACTGCTTGTA	0.632		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	44					0	0	0	0	C	7578433	C	C	7578433	4	2	99	1	0	0	0	0	0	1	0	0	16448	1294	45	2	801	2	TP53	17	7578433	Nonsense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	2313721	7578433	73616777	167	19060											
TP53	7157	broad.mit.edu	37	chr17	7578457	7578457	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgtagatggccatggcgCggacgcgggtgccgggcggg	4	6	21	10	6	0	1	0	0	0	1	0	2	0	2	2	6	1	2	2	6	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:7578457C>T	uc002gim.2	-	5	667	c.473G>A	c.(472-474)CGC>CAC	p.R158H	TP53_uc002gig.1_Missense_Mutation_p.R158H|TP53_uc002gih.2_Missense_Mutation_p.R158H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26H|TP53_uc010cng.1_Missense_Mutation_p.R26H|TP53_uc002gii.1_Missense_Mutation_p.R26H|TP53_uc010cnh.1_Missense_Mutation_p.R158H|TP53_uc010cni.1_Missense_Mutation_p.R158H|TP53_uc002gij.2_Missense_Mutation_p.R158H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65H|TP53_uc002gio.2_Missense_Mutation_p.R26H|TP53_uc010vug.1_Missense_Mutation_p.R119H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	54					0	0	0	0	T	7578457	T	T	7578457	3	4	99	1	0	0	0	0	1	0	0	0	16448	768	27	1	825	1	TP53	17	7578457	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	24	7578457	73616753	168	19061											
PFAS	5198	broad.mit.edu	37	chr17	8159892	8159892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acggcctgaggaccccacacGgccaagccgcttccagcaac	10	3	10	18	3	0	1	0	1	0	0	1	2	1	2	6	3	3	2	6	3	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:8159892G>A	uc002gkr.2	+	8	1013	c.872G>A	c.(871-873)CGG>CAG	p.R291Q	PFAS_uc010vuv.1_5'UTR	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	291					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GACCCCACACGGCCAAGCCGC	0.547													7	27					0	0	0	0	A	8159892	A	A	8159892	3	1	99	1	0	0	0	0	1	0	0	0	11809	1116	39	1	898	1	PFAS	17	8159892	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	581435	8159892	73035318	169	19062											
NT5M	56953	broad.mit.edu	37	chr17	17248203	17248203	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgctgaccttctcatagaCgaccggccggacatcacagg	9	8	10	14	3	3	2	2	1	2	1	4	4	3	3	3	3	1	1	3	3	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:17248203C>T	uc002grf.2	+	4	710	c.525C>T	c.(523-525)GAC>GAT	p.D175D	NT5M_uc002gre.2_Silent_p.D175D|NT5M_uc002grg.2_Silent_p.D175D	NM_020201	NP_064586	Q9NPB1	NT5M_HUMAN	5',3'-nucleotidase, mitochondrial precursor	175					DNA replication|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	5'-nucleotidase activity|metal ion binding|nucleotide binding				0						TTCTCATAGACGACCGGCCGG	0.602													12	34					0	0	0	0	T	17248203	T	T	17248203	2	4	99	1	0	0	0	0	0	0	0	1	10748	535	19	1		1	NT5M	17	17248203	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	9088311	17248203	63947007	170	19063											
ALDH3A2	224	broad.mit.edu	37	chr17	19555870	19555870	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttatttaggaaatgctgtGattataaagccttctgaact	12	16	7	6	0	1	2	0	2	1	0	1	3	1	3	1	1	3	1	1	1	7	7			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:19555870G>C	uc002gwb.1	+	3	617	c.396G>C	c.(394-396)GTG>GTC	p.V132V	ALDH3A2_uc002gwa.1_Silent_p.V132V|ALDH3A2_uc010cqr.1_5'UTR|ALDH3A2_uc002gwc.1_Silent_p.V132V	NM_000382	NP_000373	P51648	AL3A2_HUMAN	aldehyde dehydrogenase 3A2 isoform 2	132	Cytoplasmic.				cellular aldehyde metabolic process|central nervous system development|epidermis development|lipid metabolic process|peripheral nervous system development	endoplasmic reticulum membrane|integral to membrane	3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(2)	2	all_cancers(12;1.39e-05)|all_epithelial(12;0.00158)|Breast(13;0.245)				NADH(DB00157)	GAAATGCTGTGATTATAAAGC	0.353													10	53					0	0	0	0	C	19555870	C	C	19555870	2	2	99	1	0	0	0	0	0	0	0	1	498	1277	45	2		2	ALDH3A2	17	19555870	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	2307667	19555870	61639340	171	19064											
RUNDC1	146923	broad.mit.edu	37	chr17	41143656	41143656	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgccctcaacctgctcagtCgcctcagcagcctcaagttt	7	10	8	16	1	4	0	4	0	0	0	5	0	4	0	4	0	5	3	4	0	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:41143656C>T	uc002ici.1	+	5	1777	c.1765C>T	c.(1765-1767)CGC>TGC	p.R589C	RUNDC1_uc010whi.1_Missense_Mutation_p.R359C	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	589	RUN.										0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CCTGCTCAGTCGCCTCAGCAG	0.547													9	23					0	0	0	0	T	41143656	T	T	41143656	3	4	99	1	0	0	0	0	1	0	0	0	13807	884	31	1	1783	1	RUNDC1	17	41143656	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	21587786	41143656	40051554	172	19065											
IMP5	162540	broad.mit.edu	37	chr17	43923775	43923775	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagatgggccaacctgccttGctctacctagtgtccagcac	8	9	9	15	0	1	1	0	0	1	1	2	1	2	1	5	1	5	2	5	1	3	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:43923775G>T	uc010wka.1	+	1	1503	c.1503G>T	c.(1501-1503)TTG>TTT	p.L501F	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	501	Helical; (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		AACCTGCCTTGCTCTACCTAG	0.612													18	83					1.33834e-09	1.47788e-09	1	0	T	43923775	T	T	43923775	3	4	99	1	0	0	0	0	1	0	0	0	7760	1310	46	4	1505	4	IMP5	17	43923775	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	2780119	43923775	37271435	173	19066											
INTS2	57508	broad.mit.edu	37	chr17	59999129	59999129	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgcagcttcctccaaataTactggactctcaaaaagttc	12	12	5	12	0	2	0	1	0	2	0	6	1	4	1	2	1	3	3	2	1	5	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:59999129T>C	uc002izn.2	-	4	592	c.516A>G	c.(514-516)GTA>GTG	p.V172V	INTS2_uc002izm.2_Silent_p.V164V	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	172					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						CCTCCAAATATACTGGACTCT	0.313													6	28					0	0	0	0	C	59999129	C	C	59999129	2	2	99	1	0	0	0	0	0	0	0	1	7817	1393	49	5		5	INTS2	17	59999129	Silent	SNP	T	TCGA-CQ-5334-01A-01D-1683-08	16075354	59999129	21196081	174	19067											
PSMC5	5705	broad.mit.edu	37	chr17	61908892	61908892	+	Frame_Shift_Del	DEL	T	-	-																															ctggacattttgaagattcaTtctcggaagatgaacctgac																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:61908892delT	uc002jcb.2	+	10	1037	c.996delT	c.(994-996)CATfs	p.H332fs	PSMC5_uc010ddy.2_Frame_Shift_Del_p.H309fs|PSMC5_uc010ddz.2_Frame_Shift_Del_p.H253fs|PSMC5_uc002jcc.2_Frame_Shift_Del_p.H324fs|PSMC5_uc002jcd.2_Frame_Shift_Del_p.H324fs	NM_002805	NP_002796	P62195	PRS8_HUMAN	proteasome 26S ATPase subunit 5	332					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of programmed cell death|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|thyrotropin-releasing hormone receptor binding|transcription cofactor activity|transcription factor binding			large_intestine(1)	1						TGAAGATTCATTCTCGGAAGA	0.547													---	---	---								-	61908892	-	-	61908892	7	5	99	1	0	1	0	1	0	0	0	0	12752	1490	52	0	1034	0	PSMC5	17	61908892	Frame_Shift_Del	DEL	T	TCGA-CQ-5334-01A-01D-1683-08	1909763	61908892	19286318	175	19068											
PRKCA	5578	broad.mit.edu	37	chr17	64299053	64299053	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcaaaggggcgctgaggcaGaagaacgtgcacgaggtgaa	13	3	17	8	4	0	4	0	2	0	2	0	5	0	4	0	4	2	4	0	4	4	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:64299053G>A	uc002jfp.1	+	1	128	c.84G>A	c.(82-84)CAG>CAA	p.Q28Q	PRKCA_uc002jfo.1_5'UTR	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	28					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	CGCTGAGGCAGAAGAACGTGC	0.627													24	34					0	0	0	0	A	64299053	A	A	64299053	2	1	99	1	0	0	0	0	0	0	0	1	12569	933	33	2		2	PRKCA	17	64299053	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	2390161	64299053	16896157	176	19069											
UBE2O	63893	broad.mit.edu	37	chr17	74392877	74392877	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatcgtagtctgactcctcaAtctcagactctatgttgtac	10	14	6	11	1	4	2	2	1	3	1	7	2	5	2	1	0	1	3	1	0	5	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:74392877A>G	uc002jrm.3	-	14	2206	c.2141T>C	c.(2140-2142)ATT>ACT	p.I714T	UBE2O_uc002jrn.3_Missense_Mutation_p.I714T|UBE2O_uc002jrl.3_Missense_Mutation_p.I318T	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	714							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						TGACTCCTCAATCTCAGACTC	0.557													23	86					0	0	0	0	G	74392877	G	G	74392877	3	3	99	1	0	0	0	0	1	0	0	0	16936	101	4	5	1757	5	UBE2O	17	74392877	Missense_Mutation	SNP	A	TCGA-CQ-5334-01A-01D-1683-08	10093824	74392877	6802333	177	19070											
SLC25A10	1468	broad.mit.edu	37	chr17	79686897	79686897	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtggagacagcgaagctcGggcctctggccttttacaag	8	8	13	12	3	1	1	0	0	1	1	2	3	1	1	3	3	3	1	3	3	3	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr17:79686897G>A	uc002kbi.2	+	10	828	c.742G>A	c.(742-744)GGG>AGG	p.G248R	SLC25A10_uc010wut.1_Missense_Mutation_p.G403R|SLC25A10_uc010dif.2_Missense_Mutation_p.G257R|SLC25A10_uc010wuu.1_Missense_Mutation_p.G202R	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier;	248	Solcar 3.				gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	AGCGAAGCTCGGGCCTCTGGC	0.577													57	201					0	0	0	0	A	79686897	A	A	79686897	3	1	99	1	0	0	0	0	1	0	0	0	14536	1116	39	1	780	1	SLC25A10	17	79686897	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	5294020	79686897	1508313	178	19071											
ADCYAP1	116	broad.mit.edu	37	chr18	909477	909477	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggcggcgcgggggacgaCgcggagccgctctccaagcg	5	2	20	14	9	1	0	0	0	1	0	2	3	1	2	2	6	2	1	2	6	1	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr18:909477C>T	uc010dkg.2	+	5	491	c.372C>T	c.(370-372)GAC>GAT	p.D124D	ADCYAP1_uc010dkh.2_Silent_p.D124D	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	124					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						CGGGGGACGACGCGGAGCCGC	0.672													19	53					0	0	0	0	T	909477	T	T	909477	2	4	99	1	0	0	0	0	0	0	0	1	302	535	19	1		1	ADCYAP1	18	909477	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		909477	77167771	179	19072											
EPB41L3	23136	broad.mit.edu	37	chr18	5415859	5415859	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggtcattgtctagggaggcGctcaaggaggccgccttggg	6	8	18	9	2	3	0	2	0	1	0	3	2	3	2	2	6	0	1	2	6	2	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr18:5415859G>A	uc002kmt.1	-	13	2111	c.2025C>T	c.(2023-2025)AGC>AGT	p.S675S	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Intron|EPB41L3_uc010wzf.1_Intron|EPB41L3_uc010wzg.1_Intron|EPB41L3_uc010dkr.2_Intron	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	675	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CTAGGGAGGCGCTCAAGGAGG	0.577													10	37					0	0	0	0	A	5415859	A	A	5415859	2	1	99	1	0	0	0	0	0	0	0	1	5178	1078	38	1		1	EPB41L3	18	5415859	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	4506382	5415859	72661389	180	19073											
DSG1	1828	broad.mit.edu	37	chr18	28923432	28923432	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtcccatttttgatgatCtgttgtgattgtggaggtgc	5	17	14	5	0	1	3	0	3	1	0	2	4	2	4	1	3	1	1	1	3	0	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr18:28923432C>T	uc002kwp.2	+	12	1919	c.1707C>T	c.(1705-1707)ATC>ATT	p.I569I	DSG1_uc010xbp.1_5'Flank	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	569	Helical; (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TTTTGATGATCTGTTGTGATT	0.438													29	129					0	0	0	0	T	28923432	T	T	28923432	2	4	99	1	0	0	0	0	0	0	0	1	4798	903	32	2		2	DSG1	18	28923432	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	23507573	28923432	49153816	181	19074											
FHOD3	80206	broad.mit.edu	37	chr18	34156443	34156443	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agattatgttgtatgtggatGgaatgaatggagtaataaac	15	13	12	1	0	0	2	0	1	0	1	0	5	0	5	0	3	1	3	0	3	7	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr18:34156443G>A	uc002kzt.1	+	6	638	c.541G>A	c.(541-543)GGA>AGA	p.G181R	FHOD3_uc002kzr.1_Missense_Mutation_p.G181R|FHOD3_uc002kzs.1_Missense_Mutation_p.G181R|FHOD3_uc002kzu.1_Missense_Mutation_p.G6R	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	181	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				GTATGTGGATGGAATGAATGG	0.368													11	42					0	0	0	0	A	34156443	A	A	34156443	3	1	99	1	0	0	0	0	1	0	0	0	5915	1349	47	4	563	4	FHOD3	18	34156443	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	5233011	34156443	43920805	182	19075											
C18orf32	497661	broad.mit.edu	37	chr18	47015908	47015908	+	5'Flank	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgctcaatgaccagagaatCtacatctaaaccctggggaa	15	8	8	10	0	3	2	1	1	2	1	3	4	3	3	2	2	3	1	2	2	6	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr18:47015908C>G	uc002ldk.1	-						C18orf32_uc002ldl.2_5'Flank|C18orf32_uc002ldm.1_Missense_Mutation_p.D110H|RPL17_uc002ldn.2_Missense_Mutation_p.D72H|RPL17_uc002ldo.2_Missense_Mutation_p.D110H|RPL17_uc002ldp.2_Missense_Mutation_p.D110H|RPL17_uc002ldq.2_Missense_Mutation_p.D110H|RPL17_uc010xdg.1_Missense_Mutation_p.D72H|SNORD58C_uc002ldr.2_5'Flank	NM_001035005	NP_001030177	Q8TCD1	CR032_HUMAN	hypothetical protein LOC497661						positive regulation of I-kappaB kinase/NF-kappaB cascade		signal transducer activity				0						ACCAGAGAATCTACATCTAAA	0.438													11	24					0	0	0	0	G	47015908	G	G	47015908	1	3	99	0	1	0	0	0	0	0	0	0	1910	913	32	2		2	C18orf32	18	47015908	5'Flank	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	12859465	47015908	31061340	183	19076											
C19orf26	255057	broad.mit.edu	37	chr19	1235906	1235906	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acgtagttgtccaggatgggGtctggctctgcctgcgggtg	4	11	17	9	2	2	0	0	0	2	0	3	1	3	1	2	5	2	3	2	5	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:1235906G>A	uc002lrm.2	-	3	374	c.99C>T	c.(97-99)GAC>GAT	p.D33D		NM_152769	NP_689982	Q8N350	DOS_HUMAN	downstream of Stk11	33						integral to membrane					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGGATGGGGTCTGGCTCTG	0.682										HNSCC(14;0.022)			24	72					0	0	0	0	A	1235906	A	A	1235906	2	1	99	1	0	0	0	0	0	0	0	1	1925	1252	44	4		4	C19orf26	19	1235906	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08		1235906	57893077	184	19077											
TMEM146	257062	broad.mit.edu	37	chr19	5749165	5749165	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataatttgtattatggcaatCtgggcatcgtgccaagttcc	10	14	9	8	1	1	0	0	0	1	0	3	0	2	0	2	2	1	4	2	2	5	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:5749165C>T	uc002mda.2	+	11	1019	c.958C>T	c.(958-960)CTG>TTG	p.L320L	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	320	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTATGGCAATCTGGGCATCGT	0.264													13	34					0	0	0	0	T	5749165	T	T	5749165	2	4	99	1	0	0	0	0	0	0	0	1	16126	912	32	2		2	TMEM146	19	5749165	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	4513259	5749165	53379818	185	19078											
TRMT1	55621	broad.mit.edu	37	chr19	13220597	13220598	+	Frame_Shift_Del	DEL	CA	-	-																															ccctacctggtgtcgttgccCacagtgttcacactcggggg																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:13220597_13220598delCA	uc002mwj.2	-	9	1411_1412	c.1161_1162delTG	c.(1159-1164)TGTGGGfs	p.C387fs	TRMT1_uc010xmy.1_5'Flank|TRMT1_uc002mwk.2_Frame_Shift_Del_p.C358fs|TRMT1_uc002mwl.3_Frame_Shift_Del_p.C387fs|TRMT1_uc010xmz.1_Frame_Shift_Del_p.C173fs	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	387_388							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		TGTCGTTGCCCACAGTGTTCAC	0.624													---	---	---								-	13220598	-	-	13220597	7	5	99	1	0	1	0	1	0	0	0	0	16628	594	21	0	849	0	TRMT1	19	13220597	Frame_Shift_Del	DEL	CA	TCGA-CQ-5334-01A-01D-1683-08	7471432	13220597	45908386	186	19079											
LPHN1	22859	broad.mit.edu	37	chr19	14262302	14262302	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcggctaggttccggcctcGgggcggctcagggcccccat	4	7	15	15	4	1	0	1	0	0	0	4	0	2	0	4	7	0	3	4	7	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:14262302G>A	uc010xnn.1	-	24	4104	c.3808C>T	c.(3808-3810)CGA>TGA	p.R1270*	LPHN1_uc010xno.1_Nonsense_Mutation_p.R1265*|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	1270	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						TTCCGGCCTCGGGGCGGCTCA	0.637													12	47					0	0	0	0	A	14262302	A	A	14262302	4	1	99	1	0	0	0	0	0	1	0	0	8965	1124	39	1	620	1	LPHN1	19	14262302	Nonsense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	1041705	14262302	44866681	187	19080											
MLL4	9757	broad.mit.edu	37	chr19	36214893	36214894	+	Frame_Shift_Ins	INS	-	C	C																															ccctgctcctcggcgtcggaINSccccccgagaaaatggtgcg																										TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:36214893_36214894insC	uc010eei.2	+	9	3319_3320	c.3319_3320insC	c.(3319-3321)ACCfs	p.T1107fs		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1107					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCGGCGTCGGACCCCCCGAGAA	0.564													---	---	---								C	36214894	C	C	36214893	7	5	99	1	0	1	1	0	0	0	0	0	9676	275	10	0	3349	0	MLL4	19	36214893	Frame_Shift_Ins	INS	-	TCGA-CQ-5334-01A-01D-1683-08	21952591	36214893	22914090	188	19081											
RYR1	6261	broad.mit.edu	37	chr19	39019003	39019003	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaagcttttgtccaaacagCgccggcgggcagtcgtggcc	8	7	13	13	4	0	0	0	0	0	0	2	0	1	0	3	3	3	2	3	3	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:39019003C>T	uc002oit.2	+	74	11012	c.10882C>T	c.(10882-10884)CGC>TGC	p.R3628C	RYR1_uc002oiu.2_Missense_Mutation_p.R3623C|RYR1_uc002oiv.1_Missense_Mutation_p.R543C|RYR1_uc010xuf.1_Missense_Mutation_p.R548C	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3628					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTCCAAACAGCGCCGGCGGGC	0.612													14	28					0	0	0	0	T	39019003	T	T	39019003	3	4	99	1	0	0	0	0	1	0	0	0	13833	768	27	1	11176	1	RYR1	19	39019003	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	2804110	39019003	20109980	189	19082											
MAP4K1	11184	broad.mit.edu	37	chr19	39103292	39103292	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggtggctgtagctcggcCagttcgatggccgtgatgcc	5	9	16	11	4	0	1	0	1	0	0	2	2	0	1	3	4	3	4	3	4	1	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:39103292C>A	uc002oix.1	-	9	732	c.624G>T	c.(622-624)CTG>CTT	p.L208L	MAP4K1_uc002oiy.1_Silent_p.L208L|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	208	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GTAGCTCGGCCAGTTCGATGG	0.632													14	47					6.72482e-11	7.49705e-11	1	0	A	39103292	A	A	39103292	2	1	99	1	0	0	0	0	0	0	0	1	9312	581	21	4		4	MAP4K1	19	39103292	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	84289	39103292	20025691	190	19083											
ZC3H4	23211	broad.mit.edu	37	chr19	47589696	47589696	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgggtggtctcctcccataGagcctctgcccctgcctcgg	3	9	11	18	2	2	1	0	0	2	1	5	1	3	1	7	3	3	0	7	3	1	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:47589696G>C	uc002pga.3	-	6	853	c.815C>G	c.(814-816)TCT>TGT	p.S272C	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	272	Gly-rich.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TCCTCCCATAGAGCCTCTGCC	0.687													10	52					0	0	0	0	C	47589696	C	C	47589696	3	2	99	1	0	0	0	0	1	0	0	0	17637	942	33	2	3136	2	ZC3H4	19	47589696	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	8486404	47589696	11539287	191	19084											
ATF5	22809	broad.mit.edu	37	chr19	50436276	50436276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgggcagagtccgtggagcGcgagatccagtacgtcaagg	10	5	16	10	5	1	2	1	0	0	2	3	4	3	3	2	3	2	2	2	3	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:50436276G>A	uc010enq.1	+	4	1343	c.776G>A	c.(775-777)CGC>CAC	p.R259H	ATF5_uc002prd.2_Missense_Mutation_p.R259H	NM_012068	NP_036200	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5	259					regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			skin(2)	2		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		TCCGTGGAGCGCGAGATCCAG	0.667													6	24					0	0	0	0	A	50436276	A	A	50436276	3	1	99	1	0	0	0	0	1	0	0	0	1085	1087	38	1	782	1	ATF5	19	50436276	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	2846580	50436276	8692707	192	19085											
ZSCAN5B	342933	broad.mit.edu	37	chr19	56703265	56703265	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggcaggatctgctgctctCggcgggcctggcctgtcccc	2	9	15	15	2	2	0	0	0	2	0	4	1	3	1	4	5	2	3	4	5	0	0			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:56703265C>T	uc010ygh.1	-	2	542	c.542G>A	c.(541-543)CGA>CAA	p.R181Q		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	181					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CTGCTGCTCTCGGCGGGCCTG	0.642													5	19					0	0	0	0	T	56703265	T	T	56703265	3	4	99	1	0	0	0	0	1	0	0	0	18306	884	31	1	957	1	ZSCAN5B	19	56703265	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	6266989	56703265	2425718	193	19086											
ZSCAN18	65982	broad.mit.edu	37	chr19	58596360	58596360	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaggcatagggcttcccgcGggacaagcccggctcgtcag	7	5	15	14	4	1	0	1	0	0	0	3	1	2	1	2	4	1	4	2	4	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr19:58596360G>A	uc002qri.2	-	7	1534	c.1225C>T	c.(1225-1227)CGC>TGC	p.R409C	ZSCAN18_uc002qrj.3_Missense_Mutation_p.R408C|ZSCAN18_uc010yhs.1_Missense_Mutation_p.R273C|ZSCAN18_uc002qrh.2_Missense_Mutation_p.R409C|ZSCAN18_uc010yht.1_Missense_Mutation_p.R465C|ZSCAN18_uc002qrk.1_3'UTR|ZSCAN18_uc002qrl.2_3'UTR	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	409					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGCTTCCCGCGGGACAAGCCC	0.731													4	4					0	0	0	0	A	58596360	A	A	58596360	3	1	99	1	0	0	0	0	1	0	0	0	18297	1116	39	1	311	1	ZSCAN18	19	58596360	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	1893095	58596360	532623	194	19087											
FOXA2	3170	broad.mit.edu	37	chr20	22563766	22563766	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgttcatccccaggccggcGttcatgttgctcacggagga	6	9	12	14	4	3	0	3	0	0	0	4	2	4	2	4	4	1	4	4	4	0	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr20:22563766G>A	uc002wsn.2	-	3	286	c.96C>T	c.(94-96)AAC>AAT	p.N32N	FOXA2_uc002wsm.2_Silent_p.N38N	NM_153675	NP_710141	Q9Y261	FOXA2_HUMAN	forkhead box A2 isoform 2	32	Transactivation domain 1 (By similarity).				cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|kidney(1)|central_nervous_system(1)	4	Lung NSC(19;0.188)					CCAGGCCGGCGTTCATGTTGC	0.667													20	79					0	0	0	0	A	22563766	A	A	22563766	2	1	99	1	0	0	0	0	0	0	0	1	6022	1136	40	1		1	FOXA2	20	22563766	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08		22563766	40461754	195	19088											
BPIL3	128859	broad.mit.edu	37	chr20	31620810	31620810	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtccagagcgccatggatGagagtcatatcctggagaag	12	7	14	8	1	1	3	1	1	0	3	3	6	3	4	3	3	1	0	3	3	2	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr20:31620810G>A	uc010zuc.1	+	2	118	c.118G>A	c.(118-120)GAG>AAG	p.E40K	BPIL3_uc010zud.1_5'UTR	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	40						extracellular region	lipid binding			ovary(1)|pancreas(1)	2						CGCCATGGATGAGAGTCATAT	0.537													10	50					0	0	0	0	A	31620810	A	A	31620810	3	1	99	1	0	0	0	0	1	0	0	0	1498	1291	45	2	124	2	BPIL3	20	31620810	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	9057044	31620810	31404710	196	19089											
PHF20	51230	broad.mit.edu	37	chr20	34430552	34430552	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaaagtactcatccatttCaagcgttggaaccatcgtta	13	11	8	9	2	2	0	2	0	0	0	4	2	3	2	2	2	3	3	2	2	6	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr20:34430552C>G	uc002xek.1	+	3	252	c.141C>G	c.(139-141)TTC>TTG	p.F47L	PHF20_uc002xei.1_Missense_Mutation_p.F47L|PHF20_uc010gfo.1_Missense_Mutation_p.F47L|PHF20_uc002xej.1_5'UTR|PHF20_uc002xel.1_5'UTR	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					TCATCCATTTCAAGCGTTGGA	0.423													14	79					0	0	0	0	G	34430552	G	G	34430552	3	3	99	1	0	0	0	0	1	0	0	0	11886	825	29	2	147	2	PHF20	20	34430552	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	2809742	34430552	28594968	197	19090											
SLC32A1	140679	broad.mit.edu	37	chr20	37356976	37356976	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcccggcctgctacagcggCgacgggcgcctgaagtcctg	5	7	14	15	5	0	1	0	1	0	0	2	2	2	1	4	3	3	1	4	3	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr20:37356976C>T	uc002xjc.2	+	2	1535	c.1272C>T	c.(1270-1272)GGC>GGT	p.G424G		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	424	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GCTACAGCGGCGACGGGCGCC	0.632													8	19					0	0	0	0	T	37356976	T	T	37356976	2	4	99	1	0	0	0	0	0	0	0	1	14629	755	27	1		1	SLC32A1	20	37356976	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	2926424	37356976	25668544	198	19091											
SERINC3	10955	broad.mit.edu	37	chr20	43129936	43129936	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttggctattagtggaagtgCggatgctggaaagtgatccc	9	11	14	7	1	0	1	0	1	0	0	1	4	1	4	1	4	2	2	1	4	4	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr20:43129936C>T	uc002xme.2	-	9	1195	c.1061G>A	c.(1060-1062)CGC>CAC	p.R354H	SERINC3_uc002xmf.1_Missense_Mutation_p.R354H|SERINC3_uc010ggs.1_Missense_Mutation_p.R347H|SERINC3_uc010zwp.1_Missense_Mutation_p.R299H	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	354	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			AGTGGAAGTGCGGATGCTGGA	0.493													12	66					0	0	0	0	T	43129936	T	T	43129936	3	4	99	1	0	0	0	0	1	0	0	0	14146	768	27	1	368	1	SERINC3	20	43129936	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	5772960	43129936	19895584	199	19092											
NFATC2	4773	broad.mit.edu	37	chr20	50158922	50158922	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccgaccttcgttcggattCaaatactcatagtcgaagag	12	10	8	11	4	2	1	2	0	0	1	5	4	2	2	2	1	1	1	2	1	4	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr20:50158922C>T	uc002xwd.2	-	1	337	c.117G>A	c.(115-117)TTG>TTA	p.L39L	NFATC2_uc002xwc.2_Silent_p.L39L|NFATC2_uc010zyv.1_5'UTR|NFATC2_uc010zyw.1_5'UTR|NFATC2_uc010zyx.1_Intron|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Intron	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	39					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					CGTTCGGATTCAAATACTCAT	0.672													6	27					0	0	0	0	T	50158922	T	T	50158922	2	4	99	1	0	0	0	0	0	0	0	1	10416	825	29	2		2	NFATC2	20	50158922	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	7028986	50158922	12866598	200	19093											
ZNF831	128611	broad.mit.edu	37	chr20	57766301	57766301	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcctccagccccgcgcccCgctagtgacgggcagcctag	5	4	14	18	4	0	1	0	1	0	0	1	1	1	1	7	2	2	2	7	2	2	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr20:57766301C>T	uc002yan.2	+	1	227	c.227C>T	c.(226-228)CCG>CTG	p.P76L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	76	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CCCCGCGCCCCGCTAGTGACG	0.716													3	13					0	0	0	0	T	57766301	T	T	57766301	3	4	99	1	0	0	0	0	1	0	0	0	18252	652	23	1	229	1	ZNF831	20	57766301	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	7607379	57766301	5259219	201	19094											
SON	6651	broad.mit.edu	37	chr21	34925097	34925097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcattgcccactgagcagtCagcattaacagctgaaaata	15	8	8	10	0	1	2	1	2	0	0	1	2	1	2	1	0	6	4	1	0	4	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr21:34925097C>T	uc002yse.1	+	3	3609	c.3560C>T	c.(3559-3561)TCA>TTA	p.S1187L	SON_uc002ysb.1_Missense_Mutation_p.S1187L|SON_uc002ysc.2_Missense_Mutation_p.S1187L|SON_uc002ysd.2_Missense_Mutation_p.S178L|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.S178L	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1187					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						ACTGAGCAGTCAGCATTAACA	0.537													21	83					0	0	0	0	T	34925097	T	T	34925097	3	4	99	1	0	0	0	0	1	0	0	0	14990	838	29	2	3570	2	SON	21	34925097	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		34925097	13204798	202	19095											
PCNT	5116	broad.mit.edu	37	chr21	47831965	47831965	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatgctgctttggagccggTtgtccctgacccacaggtgg	5	11	14	11	1	0	2	0	2	0	0	1	3	1	3	3	4	3	3	3	4	0	2			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr21:47831965T>A	uc002zji.3	+	28	6085	c.5978T>A	c.(5977-5979)GTT>GAT	p.V1993D	PCNT_uc002zjj.2_Missense_Mutation_p.V1875D	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1993					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TTGGAGCCGGTTGTCCCTGAC	0.627													9	34					0	0	0	0	A	47831965	A	A	47831965	3	1	99	1	0	0	0	0	1	0	0	0	11644	1725	60	5	6088	5	PCNT	21	47831965	Missense_Mutation	SNP	T	TCGA-CQ-5334-01A-01D-1683-08	12906868	47831965	297930	203	19096											
MAPK1	5594	broad.mit.edu	37	chr22	22127164	22127164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggaacatgagctcttacctCgtcactcgggtcgtaatact	10	11	9	11	3	2	1	1	1	1	0	5	2	2	2	1	2	4	2	1	2	4	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr22:22127164C>T	uc002zvn.2	-	7	1204	c.964G>A	c.(964-966)GAG>AAG	p.E322K	MAPK1_uc002zvo.2_Missense_Mutation_p.E322K|MAPK1_uc010gtk.1_Missense_Mutation_p.E278K	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	322					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	GCTCTTACCTCGTCACTCGGG	0.478													10	46					0	0	0	0	T	22127164	T	T	22127164	3	4	99	1	0	0	0	0	1	0	0	0	9324	893	31	1	126	1	MAPK1	22	22127164	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		22127164	29177402	204	19097											
AP1B1	162	broad.mit.edu	37	chr22	29738276	29738276	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaggttggggcacccacctGagtggccaaactgaggacct	9	6	15	11	0	0	2	0	2	0	0	0	4	0	4	4	6	1	2	4	6	1	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr22:29738276G>A	uc003afj.2	-	12	1718	c.1534C>T	c.(1534-1536)CAG>TAG	p.Q512*	AP1B1_uc003afi.2_Nonsense_Mutation_p.Q512*|AP1B1_uc003afk.2_Nonsense_Mutation_p.Q512*|AP1B1_uc003afl.2_Nonsense_Mutation_p.Q512*|AP1B1_uc011ako.1_Nonsense_Mutation_p.Q65*	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	512					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GCACCCACCTGAGTGGCCAAA	0.592													3	18					0	0	0	0	A	29738276	A	A	29738276	4	1	99	1	0	0	0	0	0	1	0	0	731	1299	45	2	1363	2	AP1B1	22	29738276	Nonsense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	7611112	29738276	21566290	205	19098											
LARGE	9215	broad.mit.edu	37	chr22	33733713	33733713	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtcatactccaggaaggtCaggtagaggttgcgaaaaaa	14	7	12	8	2	2	1	2	0	0	1	3	3	3	2	2	4	2	2	2	4	6	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr22:33733713C>T	uc003and.3	-	11	1785	c.1206G>A	c.(1204-1206)CTG>CTA	p.L402L	LARGE_uc011amd.1_Silent_p.L201L|LARGE_uc003ane.3_Silent_p.L402L|LARGE_uc010gwp.2_Intron|LARGE_uc011ame.1_Silent_p.L334L|LARGE_uc011amf.1_Silent_p.L402L|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	402	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				CCAGGAAGGTCAGGTAGAGGT	0.527													15	25					0	0	0	0	T	33733713	T	T	33733713	2	4	99	1	0	0	0	0	0	0	0	1	8667	813	29	2		2	LARGE	22	33733713	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	3995437	33733713	17570853	206	19099											
SREBF2	6721	broad.mit.edu	37	chr22	42269956	42269956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccataatatcattgagaaacGatatcgctcctccatcaatg	14	11	5	11	2	2	1	2	1	0	1	5	3	4	1	3	0	1	1	3	0	5	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr22:42269956G>A	uc003bbi.2	+	5	1191	c.1022G>A	c.(1021-1023)CGA>CAA	p.R341Q	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	341	Interaction with LMNA (By similarity).|Cytoplasmic (Potential).|Basic motif.				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						ATTGAGAAACGATATCGCTCC	0.478													6	24					0	0	0	0	A	42269956	A	A	42269956	3	1	99	1	0	0	0	0	1	0	0	0	15208	1058	37	1	1040	1	SREBF2	22	42269956	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	8536243	42269956	9034610	207	19100											
CYB5R3	1727	broad.mit.edu	37	chr22	43019858	43019858	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agaatgtttgttcctgagttCctccagctcaggtcgcagca	8	12	10	11	1	1	2	1	1	0	1	5	2	4	2	3	1	2	6	3	1	1	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr22:43019858C>T	uc003bcz.2	-	8	754	c.670G>A	c.(670-672)GAA>AAA	p.E224K	CYB5R3_uc010gzc.1_Missense_Mutation_p.E98K|CYB5R3_uc003bcw.2_Missense_Mutation_p.E214K|CYB5R3_uc011aps.1_Missense_Mutation_p.E257K|CYB5R3_uc003bcy.2_Missense_Mutation_p.E201K|CYB5R3_uc003bcx.2_Missense_Mutation_p.E201K	NM_000398	NP_000389	P00387	NB5R3_HUMAN	cytochrome b5 reductase 3 isoform m	224					blood circulation|cholesterol biosynthetic process|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|hemoglobin complex|mitochondrial outer membrane	cytochrome-b5 reductase activity			skin(1)	1					NADH(DB00157)	TTCCTGAGTTCCTCCAGCTCA	0.612													21	55					0	0	0	0	T	43019858	T	T	43019858	3	4	99	1	0	0	0	0	1	0	0	0	4145	864	30	2	243	2	CYB5R3	22	43019858	Missense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	749902	43019858	8284708	208	19101											
LMF2	91289	broad.mit.edu	37	chr22	50941937	50941937	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctgcgcttctccccgctGactggtgccagcggggagga	4	7	16	14	3	1	1	0	1	1	0	2	3	1	3	4	5	3	2	4	5	0	1			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chr22:50941937G>A	uc003blp.2	-	14	2038	c.2007C>T	c.(2005-2007)GTC>GTT	p.V669V	LMF2_uc010hba.2_Silent_p.V491V|LMF2_uc003blo.2_Silent_p.V644V	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	669						endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCTCCCCGCTGACTGGTGCCA	0.672													9	24					0	0	0	0	A	50941937	A	A	50941937	2	1	99	1	0	0	0	0	0	0	0	1	8888	1277	45	2		2	LMF2	22	50941937	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	7922079	50941937	362629	209	19102											
FAM48B1	100130302	broad.mit.edu	37	chrX	24382304	24382304	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctcaggaaagatttcctCaggtaacagttttcccccac	12	10	7	12	0	2	1	2	0	0	1	4	2	4	2	3	2	2	3	3	2	3	4			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chrX:24382304C>G	uc011mjx.1	+	1	1427	c.1427C>G	c.(1426-1428)TCA>TGA	p.S476*		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						AAGATTTCCTCAGGTAACAGT	0.413													2	5					0	0	0	0	G	24382304	G	G	24382304	4	3	99	1	0	0	0	0	0	1	0	0	5605	838	29	2	1429	2	FAM48B1	23	24382304	Nonsense_Mutation	SNP	C	TCGA-CQ-5334-01A-01D-1683-08		24382304	130888256	210	19103											
SMC1A	8243	broad.mit.edu	37	chrX	53439161	53439161	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggtgttctccttggctttGatgtactgaggccgcttctg	4	15	13	9	1	2	2	0	2	2	0	3	3	2	2	2	3	1	4	2	3	1	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chrX:53439161G>C	uc004dsg.2	-	6	966	c.897C>G	c.(895-897)ATC>ATG	p.I299M	SMC1A_uc011moe.1_Missense_Mutation_p.I277M|SMC1A_uc011mof.1_Intron	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	299	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						CCTTGGCTTTGATGTACTGAG	0.502													12	15					0	0	0	0	C	53439161	C	C	53439161	3	2	99	1	0	0	0	0	1	0	0	0	14845	1280	45	2	2884	2	SMC1A	23	53439161	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	29056857	53439161	101831399	211	19104											
HUWE1	10075	broad.mit.edu	37	chrX	53573400	53573400	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttacttctgctattacctaTttgtttacaaagggtataac	11	18	5	7	0	1	0	0	0	1	0	1	0	1	0	1	1	5	3	1	1	8	11			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chrX:53573400T>C	uc004dsp.2	-	70	11314	c.10912A>G	c.(10912-10914)ATA>GTA	p.I3638V	HUWE1_uc004dsn.2_Missense_Mutation_p.I2446V|HUWE1_uc004dsq.1_5'Flank	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3638					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CTATTACCTATTTGTTTACAA	0.318													3	6					0	0	0	0	C	53573400	C	C	53573400	3	2	99	1	0	0	0	0	1	0	0	0	7500	1493	52	5	2272	5	HUWE1	23	53573400	Missense_Mutation	SNP	T	TCGA-CQ-5334-01A-01D-1683-08	134239	53573400	101697160	212	19105											
CHIC1	53344	broad.mit.edu	37	chrX	72797282	72797282	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgatactgaatttccctcCgttctaacagggaaggtaag	11	13	9	8	1	1	2	0	2	1	0	3	3	3	3	2	2	2	2	2	2	5	6			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chrX:72797282C>G	uc004ebk.3	+	2	473	c.336C>G	c.(334-336)TCC>TCG	p.S112S	CHIC1_uc010nlo.2_RNA|CHIC1_uc011mql.1_Silent_p.S112S|CHIC1_uc004ebl.3_Silent_p.S112S	NM_001039840	NP_001034929	Q5VXU3	CHIC1_HUMAN	cysteine-rich hydrophobic domain 1	112						cytoplasmic membrane-bounded vesicle|plasma membrane					0	Renal(35;0.156)					AATTTCCCTCCGTTCTAACAG	0.343													22	54					0	0	0	0	G	72797282	G	G	72797282	2	3	99	1	0	0	0	0	0	0	0	1	3358	639	23	3		3	CHIC1	23	72797282	Silent	SNP	C	TCGA-CQ-5334-01A-01D-1683-08	19223882	72797282	82473278	213	19106											
PHF6	84295	broad.mit.edu	37	chrX	133549100	133549100	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcaagagcagaatttggaGactttgatattaaaactgta	16	12	8	5	0	1	4	1	1	0	3	1	5	1	4	0	1	2	2	0	1	6	5			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chrX:133549100G>A	uc004exj.2	+	8	986	c.784G>A	c.(784-786)GAC>AAC	p.D262N	PHF6_uc004exk.2_Missense_Mutation_p.D262N|PHF6_uc011mvk.1_Missense_Mutation_p.D228N|PHF6_uc004exh.2_Missense_Mutation_p.D263N|PHF6_uc010nrr.2_Missense_Mutation_p.D262N|PHF6_uc004exi.2_Missense_Mutation_p.D263N	NM_001015877	NP_001015877	Q8IWS0	PHF6_HUMAN	PHD finger protein 6 isoform 1	262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AGAATTTGGAGACTTTGATAT	0.338													13	17					0	0	0	0	A	133549100	A	A	133549100	3	1	99	1	0	0	0	0	1	0	0	0	11893	942	33	2	813	2	PHF6	23	133549100	Missense_Mutation	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	60751818	133549100	21721460	214	19107											
SOX3	6658	broad.mit.edu	37	chrX	139586794	139586794	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgggaccataccatgaaggcGttcatgggccgtttcacacg	9	8	12	12	4	2	1	2	1	0	0	2	2	2	2	3	3	1	2	3	3	2	3			TCGA-CQ-5334-01A-01D-1683-08	TCGA-CQ-5334-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	39978192-2119-4910-a2f6-53834a2b1bf2	9ee54e26-5fd6-4d41-ac47-b95609d09cfc	g.chrX:139586794G>A	uc004fbd.1	-	1	432	c.432C>T	c.(430-432)AAC>AAT	p.N144N		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	144	HMG box.				face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					CCATGAAGGCGTTCATGGGCC	0.667													11	16					0	0	0	0	A	139586794	A	A	139586794	2	1	99	1	0	0	0	0	0	0	0	1	15015	1136	40	1		1	SOX3	23	139586794	Silent	SNP	G	TCGA-CQ-5334-01A-01D-1683-08	6037694	139586794	15683766	215	19108											
PRAMEF1	65121	broad.mit.edu	37	chr1	12854235	12854235	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaaaggtgttcatagacatCtgcctcaaggaaatacccca	14	10	7	10	0	3	1	2	0	1	1	3	2	3	2	3	2	2	1	3	2	6	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:12854235C>T	uc001auj.1	+	3	562	c.459C>T	c.(457-459)ATC>ATT	p.I153I		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	153											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCATAGACATCTGCCTCAAGG	0.522													71	273					0	0	0	0	T	12854235	T	T	12854235	2	4	100	1	0	0	0	0	0	0	0	1	12485	903	32	2		2	PRAMEF1	1	12854235	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08		12854235	236396386	1	19109											
NBPF1	55672	broad.mit.edu	37	chr1	16907926	16907926	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgttacctgggggcagaTgattccagtactttctcagc	8	12	11	10	0	1	2	1	1	1	1	3	2	2	2	2	2	3	3	2	2	2	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:16907926T>A	uc009vos.1	-	15	2256	c.1368A>T	c.(1366-1368)TCA>TCT	p.S456S	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Intron|NBPF1_uc010oce.1_Silent_p.S185S	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	456	NBPF 2.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGGGGGCAGATGATTCCAGTA	0.433													17	482					0	0	0	0	A	16907926	A	A	16907926	2	1	100	1	0	0	0	0	0	0	0	1	10245	1451	51	5		5	NBPF1	1	16907926	Silent	SNP	T	TCGA-CQ-6218-01A-11D-1912-08	4053691	16907926	232342695	2	19110											
EXTL1	2134	broad.mit.edu	37	chr1	26349593	26349593	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcagctcaatgcctctgcaAtggaacaggggcaggaacca	12	6	12	11	0	2	0	1	0	1	0	2	2	2	2	2	4	6	4	2	4	4	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:26349593A>G	uc001blf.2	+	1	1323	c.456A>G	c.(454-456)CAA>CAG	p.Q152Q		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	152	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCTCTGCAATGGAACAGGG	0.647													13	53					0	0	0	0	G	26349593	G	G	26349593	2	3	100	1	0	0	0	0	0	0	0	1	5350	98	4	5		5	EXTL1	1	26349593	Silent	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	9441667	26349593	222901028	3	19111											
KIAA0754	643314	broad.mit.edu	37	chr1	39876055	39876055	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccacaacggtctatatatGatacgatgaggataaatgag	15	11	9	6	2	1	3	0	3	1	0	2	5	2	4	1	2	2	0	1	2	7	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:39876055G>C	uc009vvt.1	+	1	880	c.118G>C	c.(118-120)GAT>CAT	p.D40H	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	Error:Variant_position_missing_in_O94854_after_alignment											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTCTATATATGATACGATGAG	0.463													15	46					0	0	0	0	C	39876055	C	C	39876055	3	2	100	1	0	0	0	0	1	0	0	0	8231	1290	45	2	120	2	KIAA0754	1	39876055	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	13526462	39876055	209374566	4	19112											
LRRC7	57554	broad.mit.edu	37	chr1	70144160	70144160	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggaagaggcctgaagaggaGtgtaagtatgtttaatagga	14	9	15	3	1	0	3	0	1	0	2	0	6	0	6	1	4	0	3	1	4	6	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:70144160G>C	uc001deo.1	+	2	1554	c.99G>C	c.(97-99)GAG>GAC	p.E33D				Q96NW7	LRRC7_HUMAN	SubName: Full=Leucine rich repeat containing 7; SubName: Full=cDNA FLJ54846, highly similar to Leucine-rich repeat-containing protein 7;	Error:Variant_position_missing_in_Q96NW7_after_alignment						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CTGAAGAGGAGTGTAAGTATG	0.408													5	12					0	0	0	0	C	70144160	C	C	70144160	3	2	100	1	0	0	0	0	1	0	0	0	9070	1044	36	4		4	LRRC7	1	70144160	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	30268105	70144160	179106461	5	19113											
C1orf173	127254	broad.mit.edu	37	chr1	75038225	75038225	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctttccttcgctctcttgCtaaatctaattccttgggta	7	17	6	11	1	2	0	0	0	2	0	6	0	4	0	2	1	2	4	2	1	4	8			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:75038225C>A	uc001dgg.2	-	14	3388	c.3169G>T	c.(3169-3171)GCA>TCA	p.A1057S		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1057	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CGCTCTCTTGCTAAATCTAAT	0.443													51	131					2.0833e-19	2.91662e-19	1	0	A	75038225	A	A	75038225	3	1	100	1	0	0	0	0	1	0	0	0	2023	797	28	4	1427	4	C1orf173	1	75038225	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	4894065	75038225	174212396	6	19114											
ABCA4	24	broad.mit.edu	37	chr1	94526180	94526180	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccaaatcactgcattggaGacaccctgatttttcaaggt	12	11	7	11	0	2	2	2	1	0	1	2	3	2	2	2	2	1	1	2	2	2	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:94526180G>A	uc001dqh.2	-	14	2177	c.2073C>T	c.(2071-2073)GTC>GTT	p.V691V	ABCA4_uc010otn.1_Silent_p.V691V	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	691					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CTGCATTGGAGACACCCTGAT	0.483													20	54					0	0	0	0	A	94526180	A	A	94526180	2	1	100	1	0	0	0	0	0	0	0	1	34	929	33	2		2	ABCA4	1	94526180	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	19487955	94526180	154724441	7	19115											
DRAM2	128338	broad.mit.edu	37	chr1	111660792	111660792	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatcctttcatcaaatatctCtggaaagtagccgtgttcgt	10	15	7	9	2	3	0	2	0	1	0	6	1	4	1	2	1	1	2	2	1	5	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:111660792C>T	uc001ead.3	-	9	1048	c.791G>A	c.(790-792)AGA>AAA	p.R264K	DRAM2_uc001eae.3_Missense_Mutation_p.R264K|DRAM2_uc009wfy.2_RNA|DRAM2_uc001eaf.3_Missense_Mutation_p.R134K	NM_178454	NP_848549	Q6UX65	DRAM2_HUMAN	transmembrane protein 77	264					apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane					0						TCAAATATCTCTGGAAAGTAG	0.368													10	53					0	0	0	0	T	111660792	T	T	111660792	3	4	100	1	0	0	0	0	1	0	0	0	4776	913	32	2	13	2	DRAM2	1	111660792	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	17134612	111660792	137589829	8	19116											
PEX19	5824	broad.mit.edu	37	chr1	160253344	160253344	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagtgtctcctggcgatctCttctggggccccgaagcatc	5	10	12	14	2	3	0	0	0	3	0	6	2	3	0	3	3	1	2	3	3	1	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:160253344C>T	uc001fvs.2	-	2	183	c.156G>A	c.(154-156)AAG>AAA	p.K52K	DCAF8_uc010pjc.1_Intron|PEX19_uc010pje.1_RNA|PEX19_uc001fvt.2_Intron	NM_002857	NP_002848	P40855	PEX19_HUMAN	peroxisomal biogenesis factor 19 isoform a	52	Necessary for PEX19 function on peroxisome biogenesis.|Docking to the peroxisome membrane and binding to PEX3.				peroxisome membrane biogenesis|peroxisome organization|protein targeting to peroxisome|transmembrane transport	brush border membrane|cytosol|integral to membrane|nucleus|peroxisomal membrane	protein binding|protein N-terminus binding				0	all_cancers(52;1.27e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTGGCGATCTCTTCTGGGGCC	0.577													21	50					0	0	0	0	T	160253344	T	T	160253344	2	4	100	1	0	0	0	0	0	0	0	1	11799	912	32	2		2	PEX19	1	160253344	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	48592552	160253344	88997277	9	19117											
UAP1	6675	broad.mit.edu	37	chr1	162536139	162536139	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccaggcctgggaaagtgaagGtactgggcatgtacatattt	11	10	13	7	0	0	1	0	1	0	0	0	2	0	2	2	4	2	3	2	4	5	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:162536139G>T	uc001gce.3	+	2	609	c.280_splice	c.e2+1	p.G94_splice		NM_003115	NP_003106	Q16222	UAP1_HUMAN	UDP-N-acetylglucosamine pyrophosphorylase 1						dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			ovary(2)|skin(2)|kidney(1)	5	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			GAAAGTGAAGGTACTGGGCAT	0.408													12	31					2.68362e-12	3.71338e-12	1	0	T	162536139	T	T	162536139	5	4	100	1	0	0	0	0	0	0	1	0	16893	1275	44	4	283	4	UAP1	1	162536139	Splice_Site	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	2282795	162536139	86714482	10	19118											
TMCO1	54499	broad.mit.edu	37	chr1	165712477	165712477	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtgtcatctcccagcagaTttcgatgagacagtccttgg	8	12	11	10	1	2	2	1	1	1	2	5	4	3	2	2	2	1	1	2	2	0	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:165712477T>C	uc001gdj.3	-	6	544	c.395A>G	c.(394-396)AAT>AGT	p.N132S	TMCO1_uc001gdl.3_Missense_Mutation_p.N48S|TMCO1_uc001gdm.3_Missense_Mutation_p.N48S|TMCO1_uc001gdk.3_Missense_Mutation_p.N120S|TMCO1_uc001gdn.3_RNA	NM_019026	NP_061899	Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1	132						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					TCCCAGCAGATTTCGATGAGA	0.378													14	43					0	0	0	0	C	165712477	C	C	165712477	3	2	100	1	0	0	0	0	1	0	0	0	16061	1493	52	5	179	5	TMCO1	1	165712477	Missense_Mutation	SNP	T	TCGA-CQ-6218-01A-11D-1912-08	3176338	165712477	83538144	11	19119											
DNM3	26052	broad.mit.edu	37	chr1	172011156	172011156	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaacaattacaggatggttCagcaatttgctgtggacttt	11	15	9	6	0	1	0	1	0	0	0	1	2	1	2	0	3	4	3	0	3	4	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:172011156C>T	uc001gie.2	+	8	1176	c.1000C>T	c.(1000-1002)CAG>TAG	p.Q334*	DNM3_uc001gid.3_Nonsense_Mutation_p.Q334*|DNM3_uc009wwb.2_Nonsense_Mutation_p.Q334*|DNM3_uc001gif.2_Nonsense_Mutation_p.Q334*	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	334					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						CAGGATGGTTCAGCAATTTGC	0.368													23	87					0	0	0	0	T	172011156	T	T	172011156	4	4	100	1	0	0	0	0	0	1	0	0	4695	827	29	2	1030	2	DNM3	1	172011156	Nonsense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	6298679	172011156	77239465	12	19120											
F13B	2165	broad.mit.edu	37	chr1	197030149	197030149	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tactttgtccttcactttgaAtgttttctgtgttgtggaat	6	21	8	6	0	2	1	1	1	1	0	3	2	3	2	1	1	1	2	1	1	3	7			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:197030149A>T	uc001gtt.1	-	4	552	c.508T>A	c.(508-510)TTC>ATC	p.F170I		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	170	Sushi 3.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTCACTTTGAATGTTTTCTGT	0.318													13	61					0	0	0	0	T	197030149	T	T	197030149	3	4	100	1	0	0	0	0	1	0	0	0	5366	101	4	5	1513	5	F13B	1	197030149	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	25018993	197030149	52220472	13	19121											
ADORA1	134	broad.mit.edu	37	chr1	203097989	203097989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgccgccctccatctcagCtttccaggccgcctacatcg	6	9	7	19	3	1	0	1	0	1	0	5	0	3	0	6	1	3	1	6	1	1	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:203097989C>T	uc001gze.1	+	3	453	c.20C>T	c.(19-21)GCT>GTT	p.A7V	ADORA1_uc001gzf.1_Missense_Mutation_p.A7V|ADORA1_uc010pqg.1_5'UTR|ADORA1_uc009xak.1_5'UTR|ADORA1_uc010pqh.1_Missense_Mutation_p.A40V	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	7	Extracellular (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	TCCATCTCAGCTTTCCAGGCC	0.657													18	81					0	0	0	0	T	203097989	T	T	203097989	3	4	100	1	0	0	0	0	1	0	0	0	326	797	28	4	22	4	ADORA1	1	203097989	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	6067840	203097989	46152632	14	19122											
TP53BP2	7159	broad.mit.edu	37	chr1	223984132	223984132	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagtaatttagttgggctGagtggccgaggaattctttc	8	13	14	6	1	1	1	0	1	1	0	2	3	1	2	1	4	0	4	1	4	3	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr1:223984132G>C	uc010pvb.1	-	13	2401	c.2109C>G	c.(2107-2109)CTC>CTG	p.L703L	TP53BP2_uc001hod.2_Silent_p.L574L|TP53BP2_uc010puz.1_5'UTR|TP53BP2_uc010pva.1_Silent_p.L342L	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	697					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		TAGTTGGGCTGAGTGGCCGAG	0.468													45	122					0	0	0	0	C	223984132	C	C	223984132	2	2	100	1	0	0	0	0	0	0	0	1	16451	1277	45	2		2	TP53BP2	1	223984132	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	20886143	223984132	25266489	15	19123											
SLC8A1	6546	broad.mit.edu	37	chr2	40366549	40366549	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtaatttgtacctggcactGatgttccaagtgcgacgaac	10	12	10	9	2	0	1	0	1	0	0	1	3	1	1	2	1	3	4	2	1	4	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr2:40366549G>C	uc002rrx.2	-	9	2561	c.2537C>G	c.(2536-2538)TCA>TGA	p.S846*	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Nonsense_Mutation_p.S841*|SLC8A1_uc002rrz.2_Nonsense_Mutation_p.S833*|SLC8A1_uc002rsa.2_Nonsense_Mutation_p.S810*|SLC8A1_uc002rsd.3_Nonsense_Mutation_p.S810*	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	846	Extracellular (Potential).|Alpha-2.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ACCTGGCACTGATGTTCCAAG	0.453													10	20					0	0	0	0	C	40366549	C	C	40366549	4	2	100	1	0	0	0	0	0	1	0	0	14770	1294	45	2	392	2	SLC8A1	2	40366549	Nonsense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		40366549	202832824	16	19124											
INPP4A	3631	broad.mit.edu	37	chr2	99154409	99154409	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agaccaacggccccctgtgaCccggtctgtggacactgtca	8	7	11	15	2	2	2	1	1	1	1	2	3	2	3	4	3	1	0	4	3	1	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr2:99154409C>T	uc002syy.2	+	8	944	c.551C>T	c.(550-552)ACC>ATC	p.T184I	INPP4A_uc010yvj.1_Missense_Mutation_p.T184I|INPP4A_uc010yvk.1_Missense_Mutation_p.T184I|INPP4A_uc002syx.2_Missense_Mutation_p.T184I|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	184					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						CCCCCTGTGACCCGGTCTGTG	0.522													5	16					0	0	0	0	T	99154409	T	T	99154409	3	4	100	1	0	0	0	0	1	0	0	0	7791	507	18	4	573	4	INPP4A	2	99154409	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	58787860	99154409	144044964	17	19125											
IL1R2	7850	broad.mit.edu	37	chr2	102638648	102638649	+	Splice_Site	INS	-	A	A																															tttccttacatctttctcagINSaaaaaaaagaagagaccatt																										TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr2:102638648_102638649insA	uc002tbm.2	+	6	918	c.689_splice	c.e6-1	p.K230_splice	IL1R2_uc002tbn.2_Splice_Site_p.K230_splice|IL1R2_uc002tbo.1_Splice_Site_p.K230_splice	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor						immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	ATCTTTCTCAGAAAAAAAAGAA	0.441													---	---	---								A	102638649	A	A	102638648	8	5	100	1	0	1	1	0	0	0	1	0	7698	956	33	0	706	0	IL1R2	2	102638648	Splice_Site	INS	-	TCGA-CQ-6218-01A-11D-1912-08	3484239	102638648	140560725	18	19126											
ACVR2A	92	broad.mit.edu	37	chr2	148653878	148653878	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attatcttataggtgctataCttggtagatcagaaactcag	13	14	8	6	0	3	2	2	0	1	2	3	2	3	2	0	2	3	2	0	2	7	7			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr2:148653878C>G	uc002twg.2	+	3	333	c.64C>G	c.(64-66)CTT>GTT	p.L22V	ACVR2A_uc010zbn.1_Intron|ACVR2A_uc002twh.2_Missense_Mutation_p.L22V	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	22	Extracellular (Potential).				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)		AGGTGCTATACTTGGTAGATC	0.328													7	49					0	0	0	0	G	148653878	G	G	148653878	3	3	100	1	0	0	0	0	1	0	0	0	223	565	20	4	70	4	ACVR2A	2	148653878	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	46015230	148653878	94545495	19	19127											
BAZ2B	29994	broad.mit.edu	37	chr2	160243034	160243034	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaaactttaccaaagtttcGtaagaactgcaccaccatga	16	9	5	11	1	0	2	0	1	0	1	1	2	0	2	3	0	4	3	3	0	6	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr2:160243034G>A	uc002uao.2	-	22	3653	c.3301C>T	c.(3301-3303)CGA>TGA	p.R1101*	BAZ2B_uc002uap.2_Nonsense_Mutation_p.R1065*	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1101	DDT.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CCAAAGTTTCGTAAGAACTGC	0.408													13	45					0	0	0	0	A	160243034	A	A	160243034	4	1	100	1	0	0	0	0	0	1	0	0	1334	1153	40	1	3269	1	BAZ2B	2	160243034	Nonsense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	11589156	160243034	82956339	20	19128											
FYCO1	79443	broad.mit.edu	37	chr3	46008282	46008282	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtgccccttcacgctccgaGcattgcagcagctcctggac	7	8	10	16	2	1	0	1	0	0	0	3	2	3	1	4	1	5	5	4	1	0	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:46008282G>A	uc003cpb.3	-	8	2750	c.2544C>T	c.(2542-2544)TGC>TGT	p.C848C	FYCO1_uc011bal.1_Silent_p.C848C	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	848	Potential.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CACGCTCCGAGCATTGCAGCA	0.627													11	24					0	0	0	0	A	46008282	A	A	46008282	2	1	100	1	0	0	0	0	0	0	0	1	6159	963	34	4		4	FYCO1	3	46008282	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		46008282	152014148	21	19129											
CELSR3	1951	broad.mit.edu	37	chr3	48697921	48697921	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtaatgctccacagactcaCggtccaggggaccactcaca	12	6	9	14	1	2	1	2	0	0	1	4	2	4	2	3	3	1	2	3	3	1	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:48697921C>T	uc003cul.2	-	1	2428	c.2147G>A	c.(2146-2148)CGT>CAT	p.R716H	CELSR3_uc003cuf.1_Missense_Mutation_p.R786H	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	716	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CACAGACTCACGGTCCAGGGG	0.557													12	26					0	0	0	0	T	48697921	T	T	48697921	3	4	100	1	0	0	0	0	1	0	0	0	3238	536	19	1	7931	1	CELSR3	3	48697921	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	2689639	48697921	149324509	22	19130											
OR5H6	79295	broad.mit.edu	37	chr3	97983471	97983471	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tatctctctctgaatgcatgGtacaatttttttcccttgta	8	19	5	9	0	2	1	0	1	2	0	5	1	3	1	1	1	2	3	1	1	5	7			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:97983471G>C	uc003dsi.1	+	1	343	c.343G>C	c.(343-345)GTA>CTA	p.V115L		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	115	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						TGAATGCATGGTACAATTTTT	0.388													23	113					0	0	0	0	C	97983471	C	C	97983471	3	2	100	1	0	0	0	0	1	0	0	0	11217	1261	44	4	345	4	OR5H6	3	97983471	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	49285550	97983471	100038959	23	19131											
GTPBP8	29083	broad.mit.edu	37	chr3	112718380	112718380	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatttgttaacatgaaaactCaaggatgttttcctcagttg	13	15	7	6	0	2	1	2	1	0	0	3	2	3	2	1	1	2	3	1	1	5	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:112718380C>G	uc003dzn.2	+	5	801	c.754C>G	c.(754-756)CAA>GAA	p.Q252E	GTPBP8_uc011bhy.1_RNA|GTPBP8_uc003dzp.2_RNA|GTPBP8_uc003dzo.2_Missense_Mutation_p.Q219E	NM_014170	NP_054889	Q8N3Z3	GTPB8_HUMAN	GTP-binding protein 8 isoform 1	252					barrier septum formation		GTP binding				0						CATGAAAACTCAAGGATGTTT	0.289													14	65					0	0	0	0	G	112718380	G	G	112718380	3	3	100	1	0	0	0	0	1	0	0	0	6923	827	29	2	772	2	GTPBP8	3	112718380	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	14734909	112718380	85304050	24	19132											
FSTL1	11167	broad.mit.edu	37	chr3	120130792	120130792	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttgaggtaggtcttgccAttactgccacacacaggcct	8	11	11	11	0	1	1	0	1	1	0	1	1	1	1	3	4	3	2	3	4	2	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:120130792A>C	uc003eds.2	-	4	382	c.207T>G	c.(205-207)AAT>AAG	p.N69K	FSTL1_uc011bjh.1_Missense_Mutation_p.N34K|FSTL1_uc010hrb.2_Missense_Mutation_p.N69K	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	follistatin-like 1 precursor	69	Kazal-like.				BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.189)		AGGTCTTGCCATTACTGCCAC	0.433													25	81					0	0	0	0	C	120130792	C	C	120130792	3	2	100	1	0	0	0	0	1	0	0	0	6111	214	8	5	751	5	FSTL1	3	120130792	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	7412412	120130792	77891638	25	19133											
ATR	545	broad.mit.edu	37	chr3	142185265	142185265	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgatggaagtgtaggtatCatgactgattgtagaggaat	13	13	13	2	0	1	4	1	3	0	1	1	6	1	6	0	3	0	3	0	3	5	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:142185265C>G	uc003eux.3	-	40	6920	c.6798G>C	c.(6796-6798)ATG>ATC	p.M2266I	ATR_uc003euy.1_Missense_Mutation_p.M152I	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2266					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						GTGTAGGTATCATGACTGATT	0.403								Other_conserved_DNA_damage_response_genes					9	49					0	0	0	0	G	142185265	G	G	142185265	3	3	100	1	0	0	0	0	1	0	0	0	1206	826	29	2	1168	2	ATR	3	142185265	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	22054473	142185265	55837165	26	19134											
TBL1XR1	79718	broad.mit.edu	37	chr3	176765338	176765338	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctagaagtgtaccttcactCtgccagagaaaaacatttct	13	11	7	10	0	3	2	1	0	2	2	3	3	3	2	2	0	3	2	2	0	5	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:176765338C>G	uc003fiw.3	-	8	963	c.703_splice	c.e8-1	p.S235_splice	TBL1XR1_uc003fix.3_Splice_Site_p.S235_splice|TBL1XR1_uc011bpz.1_Splice_Site	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1						canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			TACCTTCACTCTGCCAGAGAA	0.328													8	29					0	0	0	0	G	176765338	G	G	176765338	5	3	100	1	0	0	0	0	0	0	1	0	15706	927	32	2	878	2	TBL1XR1	3	176765338	Splice_Site	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	34580073	176765338	21257092	27	19135											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			11	43					0	0	0	0	A	178936082	A	A	178936082	3	1	100	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	2170744	178936082	19086348	28	19136											
EPHB3	2049	broad.mit.edu	37	chr3	184294876	184294876	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatctgctggcccacacgcGctacacctttgaggtgcagg	7	8	11	15	2	1	1	0	1	1	0	1	1	1	1	3	3	3	3	3	3	1	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr3:184294876G>A	uc003foz.2	+	5	1696	c.1259G>A	c.(1258-1260)CGC>CAC	p.R420H		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	420	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCCCACACGCGCTACACCTTT	0.627													19	40					0	0	0	0	A	184294876	A	A	184294876	3	1	100	1	0	0	0	0	1	0	0	0	5200	1087	38	1	1277	1	EPHB3	3	184294876	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	5358794	184294876	13727554	29	19137											
ADD1	118	broad.mit.edu	37	chr4	2930158	2930158	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgccgcggaccctggcagcGatgggtctccaggcaagtcc	6	5	14	16	4	1	0	0	0	1	0	3	2	2	1	5	4	1	2	5	4	1	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:2930158G>A	uc003gfr.2	+	15	2310	c.2122G>A	c.(2122-2124)GAT>AAT	p.D708N	ADD1_uc003gfn.2_RNA|ADD1_uc003gfo.2_3'UTR|ADD1_uc003gfp.2_3'UTR|ADD1_uc003gfq.2_Missense_Mutation_p.D739N|ADD1_uc003gfs.2_3'UTR	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	708					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCCTGGCAGCGATGGGTCTCC	0.632													28	99					0	0	0	0	A	2930158	A	A	2930158	3	1	100	1	0	0	0	0	1	0	0	0	304	1058	37	1	2307	1	ADD1	4	2930158	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		2930158	188224118	30	19138											
AFM	173	broad.mit.edu	37	chr4	74350097	74350097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagacgctcccagagtgttCaaaattacctgtaagtaaat	15	10	7	9	1	1	2	1	0	0	2	2	2	2	2	2	0	1	4	2	0	7	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:74350097C>T	uc003hhb.2	+	3	291	c.260C>T	c.(259-261)TCA>TTA	p.S87L		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	87	Albumin 1.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCAGAGTGTTCAAAATTACCT	0.279													12	32					0	0	0	0	T	74350097	T	T	74350097	3	4	100	1	0	0	0	0	1	0	0	0	361	838	29	2	270	2	AFM	4	74350097	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	71419939	74350097	116804179	31	19139											
FNIP2	57600	broad.mit.edu	37	chr4	159753081	159753081	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctcagttgccatgagttaCaaaggctccaccttaaagat	12	10	9	10	0	1	2	1	1	0	1	2	2	2	2	3	2	2	4	3	2	4	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:159753081C>T	uc003iqe.3	+	4	633	c.450C>T	c.(448-450)TAC>TAT	p.Y150Y	FNIP2_uc003iqd.2_Silent_p.Y150Y	NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	150					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CCATGAGTTACAAAGGCTCCA	0.408													5	15					0	0	0	0	T	159753081	T	T	159753081	2	4	100	1	0	0	0	0	0	0	0	1	6008	489	17	4		4	FNIP2	4	159753081	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	85402984	159753081	31401195	32	19140											
WDR17	116966	broad.mit.edu	37	chr4	177071078	177071078	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataaatattctggcagacaGatcttgggaagaaattattg	16	12	9	4	0	2	3	0	0	2	3	2	4	2	4	0	2	0	1	0	2	7	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:177071078G>C	uc003iuj.2	+	15	2246	c.2090G>C	c.(2089-2091)AGA>ACA	p.R697T	WDR17_uc003iuk.2_Missense_Mutation_p.R673T|WDR17_uc003ium.3_Missense_Mutation_p.R673T|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_5'Flank	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	697										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CTGGCAGACAGATCTTGGGAA	0.383													3	83					0	0	0	0	C	177071078	C	C	177071078	3	2	100	1	0	0	0	0	1	0	0	0	17345	942	33	2	2144	2	WDR17	4	177071078	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	17317997	177071078	14083198	33	19141											
FAT1	2195	broad.mit.edu	37	chr4	187522449	187522449	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatgctatagtcagttcctcGagcatacatgacaaccgcat	12	10	8	11	2	1	1	1	1	0	0	3	3	2	1	2	0	4	4	2	0	4	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:187522449G>A	uc003izf.2	-	21	11802	c.11614C>T	c.(11614-11616)CGA>TGA	p.R3872*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3872	Extracellular (Potential).|Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TCAGTTCCTCGAGCATACATG	0.393										HNSCC(5;0.00058)			11	27					0	0	0	0	A	187522449	A	A	187522449	4	1	100	1	0	0	0	0	0	1	0	0	5721	1066	37	1	2180	1	FAT1	4	187522449	Nonsense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	10451371	187522449	3631827	34	19142											
FAT1	2195	broad.mit.edu	37	chr4	187540720	187540742	+	Frame_Shift_Del	DEL	GCCAGTGCTGCTGTCTACATGAA	-	-																															gttctgagtagtgagatgagGccagtgctgctgtctacatg																										TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr4:187540720_187540742delGCCAGTGCTGCTGTCTACATGAA	uc003izf.2	-	10	7186_7208	c.6998_7020delTTCATGTAGACAGCAGCACTGGC	c.(6997-7020)TTTCATGTAGACAGCAGCACTGGCfs	p.F2333fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2333_2340	Extracellular (Potential).|Cadherin 21.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTGAGATGAGGCCAGTGCTGCTGTCTACATGAAAATGATCATG	0.48										HNSCC(5;0.00058)			---	---	---								-	187540742	-	-	187540720	7	5	100	1	0	1	0	1	0	0	0	0	5721	1190	42	0	6818	0	FAT1	4	187540720	Frame_Shift_Del	DEL	GCCAGTGCTGCTGTCTACATGAA	TCGA-CQ-6218-01A-11D-1912-08	18271	187540720	3613556	35	19143											
NUP155	9631	broad.mit.edu	37	chr5	37303483	37303483	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgatcaactttggccattcGgactagatgtggctccagaa	10	12	10	9	1	1	3	1	1	0	2	3	4	2	4	2	3	1	1	2	3	3	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:37303483G>A	uc003jku.1	-	28	3314	c.3196C>T	c.(3196-3198)CGA>TGA	p.R1066*	NUP155_uc003jkt.1_Nonsense_Mutation_p.R1007*|NUP155_uc010iuz.1_Nonsense_Mutation_p.R1002*	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	1066					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGGCCATTCGGACTAGATGT	0.378													13	37					0	0	0	0	A	37303483	A	A	37303483	4	1	100	1	0	0	0	0	0	1	0	0	10810	1124	39	1	1011	1	NUP155	5	37303483	Nonsense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		37303483	143611777	36	19144											
C7	730	broad.mit.edu	37	chr5	40936557	40936557	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctgtgatatcgataaacCtcctcctaacatagaactta	13	13	4	11	1	0	2	0	1	0	1	4	3	3	2	4	0	3	0	4	0	7	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:40936557C>A	uc003jmh.2	+	5	512	c.398C>A	c.(397-399)CCT>CAT	p.P133H	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	133	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				ATCGATAAACCTCCTCCTAAC	0.403													17	26					6.94344e-10	9.38943e-10	1	0	A	40936557	A	A	40936557	3	1	100	1	0	0	0	0	1	0	0	0	2386	681	24	4	416	4	C7	5	40936557	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	3633074	40936557	139978703	37	19145											
CCDC125	202243	broad.mit.edu	37	chr5	68581236	68581236	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcttagaactgttttctgaAgggagcatacccaacagtct	11	12	8	10	0	3	2	0	1	3	1	3	3	3	3	1	1	4	2	1	1	5	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:68581236A>G	uc003jvv.1	-	10	1201	c.1158T>C	c.(1156-1158)CCT>CCC	p.P386P	CCDC125_uc003jvx.1_Missense_Mutation_p.L327P|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_Silent_p.P261P	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	386						cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		TGTTTTCTGAAGGGAGCATAC	0.418													17	57					0	0	0	0	G	68581236	G	G	68581236	2	3	100	1	0	0	0	0	0	0	0	1	2773	59	3	5		5	CCDC125	5	68581236	Silent	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	27644679	68581236	112334024	38	19146											
SPATA9	83890	broad.mit.edu	37	chr5	94994576	94994576	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggattcttcttcctggaaGatgttctttaccttcttcag	7	18	7	9	0	5	1	1	0	4	1	6	3	6	3	2	2	1	1	2	2	2	8			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:94994576G>C	uc003klj.1	-	5	672	c.516C>G	c.(514-516)ATC>ATG	p.I172M	SPATA9_uc010jbh.1_RNA|SPATA9_uc003klh.1_RNA|SPATA9_uc003kli.1_RNA	NM_031952	NP_114158	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	172					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane					0		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		CTTCCTGGAAGATGTTCTTTA	0.383													12	53					0	0	0	0	C	94994576	C	C	94994576	3	2	100	1	0	0	0	0	1	0	0	0	15082	932	33	2	252	2	SPATA9	5	94994576	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	26413340	94994576	85920684	39	19147											
KCNN2	3781	broad.mit.edu	37	chr5	113831673	113831673	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaggattgttaccctggaaAcaaaactagagactttgatt	15	11	9	6	0	0	3	0	1	0	2	0	6	0	5	1	2	3	1	1	2	5	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:113831673A>G	uc003kqo.2	+	8	1991	c.1534A>G	c.(1534-1536)ACA>GCA	p.T512A	KCNN2_uc003kqp.2_Missense_Mutation_p.T164A|KCNN2_uc010jcg.2_RNA|uc003kqr.1_Intron	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	512						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TACCCTGGAAACAAAACTAGA	0.448													20	116					0	0	0	0	G	113831673	G	G	113831673	3	3	100	1	0	0	0	0	1	0	0	0	8118	43	2	5	1564	5	KCNN2	5	113831673	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	18837097	113831673	67083587	40	19148											
PCDHB4	56131	broad.mit.edu	37	chr5	140501700	140501700	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgttggaggaaacagagagCggctcctttgtagcccatct	9	10	13	9	1	1	1	0	0	1	1	2	4	2	3	2	3	3	3	2	3	2	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:140501700C>T	uc003lip.1	+	1	120	c.120C>T	c.(118-120)AGC>AGT	p.S40S		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	40	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAACAGAGAGCGGCTCCTTTG	0.537													11	57					0	0	0	0	T	140501700	T	T	140501700	2	4	100	1	0	0	0	0	0	0	0	1	11598	767	27	1		1	PCDHB4	5	140501700	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	26670027	140501700	40413560	41	19149											
PCDHGB2	56103	broad.mit.edu	37	chr5	140741612	140741612	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccttgggcgacagggacgCggcccgccagcgcctgctgg	4	5	17	15	5	0	0	0	0	0	0	0	2	0	1	4	4	3	1	4	4	0	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:140741612C>T	uc003ljs.1	+	1	1910	c.1910C>T	c.(1909-1911)GCG>GTG	p.A637V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.A637V|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	637	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAGGGACGCGGCCCGCCAG	0.692													8	17					0	0	0	0	T	140741612	T	T	140741612	3	4	100	1	0	0	0	0	1	0	0	0	11617	768	27	1	1912	1	PCDHGB2	5	140741612	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	239912	140741612	40173648	42	19150											
SH3TC2	79628	broad.mit.edu	37	chr5	148386619	148386619	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagccaggcggtgaaaggccAccagctcttgcctctgatct	8	9	11	13	1	3	2	0	2	3	0	3	2	3	2	4	3	3	1	4	3	2	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:148386619A>G	uc003lpu.2	-	16	3652	c.3500T>C	c.(3499-3501)GTG>GCG	p.V1167A	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.V811A|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Missense_Mutation_p.V714A|SH3TC2_uc010jgx.2_Missense_Mutation_p.V1160A	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1167	TPR 7.						binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAAAGGCCACCAGCTCTTG	0.458													18	80					0	0	0	0	G	148386619	G	G	148386619	3	3	100	1	0	0	0	0	1	0	0	0	14327	159	6	5	374	5	SH3TC2	5	148386619	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	7645007	148386619	32528641	43	19151											
ARSI	340075	broad.mit.edu	37	chr5	149677008	149677008	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggctgtgcggttatattcGgccaggcgagccagcagggt	7	9	16	9	3	0	0	0	0	0	0	1	1	0	0	2	5	3	3	2	5	2	3	rs141146390		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr5:149677008G>A	uc003lrv.2	-	2	2068	c.1479C>T	c.(1477-1479)GCC>GCT	p.A493A		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	493						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTTATATTCGGCCAGGCGAG	0.632													25	95					0	0	0	0	A	149677008	A	A	149677008	2	1	100	1	0	0	0	0	0	0	0	1	996	1103	39	1		1	ARSI	5	149677008	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	1290389	149677008	31238252	44	19152											
HIST1H2BG	8339	broad.mit.edu	37	chr6	26216707	26216707	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcccatggccttggatgaGatgccagtatcggggtgaac	9	9	14	9	1	0	2	0	2	0	1	1	4	0	3	3	4	3	1	3	4	2	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:26216707G>C	uc003ngz.2	-	1	166	c.165C>G	c.(163-165)ATC>ATG	p.I55M	HIST1H2AE_uc003nha.1_5'Flank	NM_003518	NP_003509	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	55					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				CCTTGGATGAGATGCCAGTAT	0.537													39	206					0	0	0	0	C	26216707	C	C	26216707	3	2	100	1	0	0	0	0	1	0	0	0	7185	932	33	2	219	2	HIST1H2BG	6	26216707	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		26216707	144898360	45	19153											
OR2J2	26707	broad.mit.edu	37	chr6	29142034	29142034	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggtcatgagctccatttttGttctcatacctctcattctc	6	18	5	12	0	4	1	3	1	3	0	8	1	5	1	2	1	2	2	2	1	1	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:29142034G>T	uc011dlm.1	+	1	724	c.622G>T	c.(622-624)GTT>TTT	p.V208F		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTCCATTTTTGTTCTCATACC	0.468													43	109					2.26627e-22	3.21056e-22	1	0	T	29142034	T	T	29142034	3	4	100	1	0	0	0	0	1	0	0	0	11057	1377	48	4	624	4	OR2J2	6	29142034	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	2925327	29142034	141973033	46	19154											
MCCD1	401250	broad.mit.edu	37	chr6	31495806	31495810	+	5'Flank	DEL	AAAAA	-	-																															acagagcgagactccgtctcAaaaaaaaaaaaaaaaaaaaa																								rs147277013		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:31495806_31495810delAAAAA	uc003ntp.1	+							NM_001011700	NP_001011700	P59942	MCCD1_HUMAN	mitochondrial coiled-coil domain 1 precursor							mitochondrion					0						actccgtctcaaaaaaaaaaaaaaa	0.2													---	---	---								-	31495810	-	-	31495806	6	5	100	0	1	1	0	1	0	0	0	0	9429	145	5	0		0	MCCD1	6	31495806	5'Flank	DEL	AAAAA	TCGA-CQ-6218-01A-11D-1912-08	2353772	31495806	139619261	47	19155											
KCNK5	8645	broad.mit.edu	37	chr6	39158824	39158824	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagccccctgctgggggcTctcctcccctgccaagttgt	3	11	10	17	0	2	0	1	0	1	0	4	0	3	0	6	2	3	3	6	2	1	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:39158824T>C	uc003oon.2	-	5	1706	c.1342A>G	c.(1342-1344)AGC>GGC	p.S448G		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	448					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						TGCTGGGGGCTCTCCTCCCCT	0.627													4	12					0	0	0	0	C	39158824	C	C	39158824	3	2	100	1	0	0	0	0	1	0	0	0	8108	1551	54	5	161	5	KCNK5	6	39158824	Missense_Mutation	SNP	T	TCGA-CQ-6218-01A-11D-1912-08	7663018	39158824	131956243	48	19156											
LGSN	51557	broad.mit.edu	37	chr6	63989944	63989944	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctaaataaaatactctaaGaatttatttctctctgcagc	14	16	3	8	0	4	1	0	0	4	1	5	1	4	1	0	0	3	1	0	0	8	8			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:63989944G>A	uc003peh.2	-	4	1546	c.1512C>T	c.(1510-1512)TTC>TTT	p.F504F	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	504					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	AATACTCTAAGAATTTATTTC	0.328													9	55					0	0	0	0	A	63989944	A	A	63989944	2	1	100	1	0	0	0	0	0	0	0	1	8800	933	33	2		2	LGSN	6	63989944	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	24831120	63989944	107125123	49	19157											
MYO6	4646	broad.mit.edu	37	chr6	76591501	76591501	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcacatgcagtcgctggaaGaaagttcagtggtgctcact	10	10	11	10	1	3	1	3	0	0	1	4	2	3	2	0	2	2	4	0	2	2	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:76591501G>A	uc003pih.1	+	23	2661	c.2382G>A	c.(2380-2382)AAG>AAA	p.K794K	MYO6_uc003pig.1_Silent_p.K794K|MYO6_uc003pii.1_Silent_p.K794K	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	794	Required for binding calmodulin (By similarity).				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GTCGCTGGAAGAAAGTTCAGT	0.418													23	77					0	0	0	0	A	76591501	A	A	76591501	2	1	100	1	0	0	0	0	0	0	0	1	10134	933	33	2		2	MYO6	6	76591501	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	12601557	76591501	94523566	50	19158											
MDN1	23195	broad.mit.edu	37	chr6	90392899	90392899	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctccctcagtgccctgttCagattctgaatggaagacag	9	11	10	11	0	4	3	2	1	2	2	5	4	4	4	2	1	1	1	2	1	2	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:90392899C>T	uc003pnn.1	-	73	12170	c.12054G>A	c.(12052-12054)CTG>CTA	p.L4018L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4018					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTGCCCTGTTCAGATTCTGAA	0.547													18	47					0	0	0	0	T	90392899	T	T	90392899	2	4	100	1	0	0	0	0	0	0	0	1	9468	813	29	2		2	MDN1	6	90392899	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	13801398	90392899	80722168	51	19159											
RFX6	222546	broad.mit.edu	37	chr6	117246698	117246698	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagcatggtttccagcgaCgctgtgaagaatgaaagcca	12	7	14	8	2	0	3	0	2	0	1	1	5	1	4	2	2	3	3	2	2	3	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:117246698C>T	uc003pxm.2	+	16	1824	c.1761C>T	c.(1759-1761)GAC>GAT	p.D587D		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	587					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TTTCCAGCGACGCTGTGAAGA	0.517													30	95					0	0	0	0	T	117246698	T	T	117246698	2	4	100	1	0	0	0	0	0	0	0	1	13332	535	19	1		1	RFX6	6	117246698	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	26853799	117246698	53868369	52	19160											
CLVS2	134829	broad.mit.edu	37	chr6	123319045	123319045	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agggatatggtcatcaccagGccggacattggctttctgcg	8	10	13	10	2	3	0	2	0	1	0	3	2	3	2	2	5	1	1	2	5	1	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:123319045G>C	uc003pzi.1	+	2	992	c.123G>C	c.(121-123)AGG>AGC	p.R41S		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	41					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TCATCACCAGGCCGGACATTG	0.567													19	53					0	0	0	0	C	123319045	C	C	123319045	3	2	100	1	0	0	0	0	1	0	0	0	3587	1194	42	4	125	4	CLVS2	6	123319045	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	6072347	123319045	47796022	53	19161											
AKAP7	9465	broad.mit.edu	37	chr6	131540807	131540807	+	Frame_Shift_Del	DEL	A	-	-																															tttttcatttcaagggagtgAaaaaaatagatcctgattta																										TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:131540807delA	uc003qck.2	+	7	742	c.709delA	c.(709-711)AAAfs	p.K237fs	AKAP7_uc011ebz.1_Frame_Shift_Del_p.K215fs|AKAP7_uc003qcl.1_Frame_Shift_Del_p.K118fs	NM_016377	NP_057461	O43687	AKA7A_HUMAN	A-kinase anchor protein 7 isoform gamma	Error:Variant_position_missing_in_O43687_after_alignment					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			ovary(2)	2	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)		CAAGGGAGTGAAAAAAATAGA	0.308													---	---	---								-	131540807	-	-	131540807	7	5	100	1	0	1	0	1	0	0	0	0	456	247	9	0	665	0	AKAP7	6	131540807	Frame_Shift_Del	DEL	A	TCGA-CQ-6218-01A-11D-1912-08	8221762	131540807	39574260	54	19162											
C6orf118	168090	broad.mit.edu	37	chr6	165706919	165706919	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctgatcgttcctttgcaGactgcagcaatgccacctcc	7	11	8	15	1	0	2	0	1	0	1	3	2	2	2	5	0	5	4	5	0	1	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr6:165706919G>A	uc003qum.3	-	6	1139	c.1103C>T	c.(1102-1104)TCT>TTT	p.S368F	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	368	Potential.										0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TTCCTTTGCAGACTGCAGCAA	0.453													39	109					0	0	0	0	A	165706919	A	A	165706919	3	1	100	1	0	0	0	0	1	0	0	0	2333	942	33	2	322	2	C6orf118	6	165706919	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	34166112	165706919	5408148	55	19163											
DNAH11	8701	broad.mit.edu	37	chr7	21882167	21882167	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgctccgtttaggtataTcaggattggagataaagaat	12	15	10	4	1	1	2	1	0	0	2	2	4	2	3	1	3	1	3	1	3	6	8			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:21882167T>A	uc003svc.2	+	67	10749	c.10718T>A	c.(10717-10719)ATC>AAC	p.I3573N		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3573	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TTTAGGTATATCAGGATTGGA	0.388									Kartagener_syndrome				8	39					0	0	0	0	A	21882167	A	A	21882167	3	1	100	1	0	0	0	0	1	0	0	0	4621	1435	50	5	10981	5	DNAH11	7	21882167	Missense_Mutation	SNP	T	TCGA-CQ-6218-01A-11D-1912-08		21882167	137256496	56	19164											
C7orf30	115416	broad.mit.edu	37	chr7	23339007	23339007	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtgtggcgcggctgctcgcCccactaatgtggcgcagggc	4	7	16	14	5	0	0	0	0	0	0	1	0	0	0	2	4	1	3	2	4	1	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:23339007C>T	uc003swd.1	+	1	68	c.36C>T	c.(34-36)GCC>GCT	p.A12A		NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	12						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			GGCTGCTCGCCCCACTAATGT	0.716													4	15					0	0	0	0	T	23339007	T	T	23339007	2	4	100	1	0	0	0	0	0	0	0	1	2397	610	22	4		4	C7orf30	7	23339007	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	1456840	23339007	135799656	57	19165											
TBX20	57057	broad.mit.edu	37	chr7	35244106	35244106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttggggttgtctgactctCatcccccaagacatcttctt	7	15	7	12	0	4	2	1	1	4	1	6	2	5	2	2	2	0	1	2	2	1	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:35244106C>T	uc011kas.1	-	7	990	c.979G>A	c.(979-981)GAG>AAG	p.E327K		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	327						nucleus	DNA binding			central_nervous_system(1)	1						GTCTGACTCTCATCCCCCAAG	0.512													10	36					0	0	0	0	T	35244106	T	T	35244106	3	4	100	1	0	0	0	0	1	0	0	0	15722	835	29	2	371	2	TBX20	7	35244106	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	11905099	35244106	123894557	58	19166											
ABCA13	154664	broad.mit.edu	37	chr7	48284272	48284272	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatggagctctcagaaatgcGatagctcagaatttacattt	13	12	9	7	1	2	2	2	0	1	2	3	5	2	3	0	1	4	2	0	1	4	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:48284272G>A	uc003toq.2	+	11	1387	c.1362G>A	c.(1360-1362)GCG>GCA	p.A454A	ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	454					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TCAGAAATGCGATAGCTCAGA	0.418													18	53					0	0	0	0	A	48284272	A	A	48284272	2	1	100	1	0	0	0	0	0	0	0	1	31	1045	37	1		1	ABCA13	7	48284272	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	13040166	48284272	110854391	59	19167											
SEMA3A	10371	broad.mit.edu	37	chr7	83764187	83764187	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aacatacagcctactccgttCctcatccaaaaggaaggtat	14	9	6	12	1	1	0	1	0	0	0	4	1	4	1	4	2	4	2	4	2	7	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr7:83764187C>T	uc003uhz.2	-	2	508	c.193G>A	c.(193-195)GAA>AAA	p.E65K		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	65	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						CTACTCCGTTCCTCATCCAAA	0.383													17	40					0	0	0	0	T	83764187	T	T	83764187	3	4	100	1	0	0	0	0	1	0	0	0	14089	864	30	2	2186	2	SEMA3A	7	83764187	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	35479915	83764187	75374476	60	19168											
ASAH1	427	broad.mit.edu	37	chr8	17918918	17918918	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tccagaactgttctagtgagGaaccctatccacatgacatc	12	10	7	12	0	1	3	0	2	1	1	4	4	3	4	3	1	2	1	3	1	4	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:17918918G>C	uc003wyl.2	-	10	1065	c.753C>G	c.(751-753)TTC>TTG	p.F251L	ASAH1_uc010ltb.1_RNA|ASAH1_uc003wym.2_Missense_Mutation_p.F226L|ASAH1_uc003wyn.2_Missense_Mutation_p.F267L|ASAH1_uc003wyo.2_Missense_Mutation_p.F245L	NM_177924	NP_808592	Q13510	ASAH1_HUMAN	N-acylsphingosine amidohydrolase 1 isoform a	251					ceramide metabolic process	lysosome	ceramidase activity				0				Colorectal(111;0.0646)|COAD - Colon adenocarcinoma(73;0.228)		TTCTAGTGAGGAACCCTATCC	0.318													12	48					0	0	0	0	C	17918918	C	C	17918918	3	2	100	1	0	0	0	0	1	0	0	0	1008	1165	41	2	454	2	ASAH1	8	17918918	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		17918918	128445104	61	19169											
ENTPD4	9583	broad.mit.edu	37	chr8	23306270	23306270	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacctttgaaatttcttgTctctggttagtcgcccatac	7	17	6	11	1	2	1	0	1	2	0	4	1	2	1	2	1	2	1	2	1	4	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:23306270T>C	uc003xdl.2	-	3	355	c.191A>G	c.(190-192)GAC>GGC	p.D64G	ENTPD4_uc011kzu.1_Missense_Mutation_p.D64G|ENTPD4_uc003xdm.2_Missense_Mutation_p.D64G|ENTPD4_uc011kzv.1_Missense_Mutation_p.D64G|ENTPD4_uc011kzw.1_Missense_Mutation_p.D30G	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	64	Lumenal (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		AAATTTCTTGTCTCTGGTTAG	0.299													17	58					0	0	0	0	C	23306270	C	C	23306270	3	2	100	1	0	0	0	0	1	0	0	0	5165	1667	58	5	1703	5	ENTPD4	8	23306270	Missense_Mutation	SNP	T	TCGA-CQ-6218-01A-11D-1912-08	5387352	23306270	123057752	62	19170											
DOCK5	80005	broad.mit.edu	37	chr8	25267635	25267635	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctccccatcgttgcagacaGatggaatcgcggccactcct	8	8	10	15	3	0	2	0	0	0	2	4	3	2	3	4	2	1	3	4	2	1	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:25267635G>A	uc003xeg.2	+	51	5562	c.5425G>A	c.(5425-5427)GAT>AAT	p.D1809N	PPP2R2A_uc003xek.2_Intron|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1809	Pro-rich.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GTTGCAGACAGATGGAATCGC	0.552													9	17					0	0	0	0	A	25267635	A	A	25267635	3	1	100	1	0	0	0	0	1	0	0	0	4712	942	33	2	5627	2	DOCK5	8	25267635	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	1961365	25267635	121096387	63	19171											
CSPP1	79848	broad.mit.edu	37	chr8	68028171	68028171	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatagactaaagcagtttaGtgtggcaccaagacactttg	13	11	10	7	0	0	3	0	1	0	2	0	3	0	3	1	1	1	3	1	1	5	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:68028171G>T	uc003xxi.2	+	13	1431	c.1400G>T	c.(1399-1401)AGT>ATT	p.S467I	CSPP1_uc003xxg.1_Missense_Mutation_p.S459I|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.S432I|CSPP1_uc003xxk.2_Missense_Mutation_p.S138I	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	467						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAGCAGTTTAGTGTGGCACCA	0.413													14	81					4.3838e-07	5.82874e-07	1	0	T	68028171	T	T	68028171	3	4	100	1	0	0	0	0	1	0	0	0	3979	1029	36	4	1450	4	CSPP1	8	68028171	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	42760536	68028171	78335851	64	19172											
SLCO5A1	81796	broad.mit.edu	37	chr8	70585257	70585257	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaattctccctgggtgctGaaagctgggcaagatctagt	9	11	13	8	0	2	2	0	1	2	1	3	3	2	3	1	3	2	3	1	3	4	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:70585257G>A	uc003xyl.2	-	10	3101	c.2394C>T	c.(2392-2394)TTC>TTT	p.F798F	SLCO5A1_uc010lzb.2_Silent_p.F743F|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	798	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCTGGGTGCTGAAAGCTGGGC	0.577													26	120					0	0	0	0	A	70585257	A	A	70585257	2	1	100	1	0	0	0	0	0	0	0	1	14795	1281	45	2		2	SLCO5A1	8	70585257	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	2557086	70585257	75778765	65	19173											
RUNX1T1	862	broad.mit.edu	37	chr8	93026818	93026818	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgcttaccactagtcccaGaacgagggtgcgaactcttt	9	12	9	11	2	1	1	0	0	1	1	2	3	2	1	2	1	5	1	2	1	4	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:93026818G>A	uc003yfd.2	-	3	541	c.457C>T	c.(457-459)CTG>TTG	p.L153L	RUNX1T1_uc003yfc.1_Silent_p.L126L|RUNX1T1_uc003yfe.1_Silent_p.L116L|RUNX1T1_uc010mao.2_Silent_p.L126L|RUNX1T1_uc011lgi.1_Silent_p.L164L|RUNX1T1_uc003yfh.1_Silent_p.L116L|RUNX1T1_uc003yfb.1_Silent_p.L116L|RUNX1T1_uc003yff.1_Silent_p.L116L|RUNX1T1_uc003yfg.1_Silent_p.L116L	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	153	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			ACTAGTCCCAGAACGAGGGTG	0.493													41	74					0	0	0	0	A	93026818	A	A	93026818	2	1	100	1	0	0	0	0	0	0	0	1	13812	933	33	2		2	RUNX1T1	8	93026818	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	22441561	93026818	53337204	66	19174											
CSMD3	114788	broad.mit.edu	37	chr8	113564847	113564847	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatatttccaggatctaccTcaatcatccacatgcaacgc	13	10	4	14	1	3	0	2	0	1	0	5	1	5	1	3	1	3	1	3	1	5	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:113564847T>A	uc003ynu.2	-	26	4496	c.4337A>T	c.(4336-4338)GAG>GTG	p.E1446V	CSMD3_uc003yns.2_Missense_Mutation_p.E718V|CSMD3_uc003ynt.2_Missense_Mutation_p.E1406V|CSMD3_uc011lhx.1_Missense_Mutation_p.E1342V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1446	Extracellular (Potential).|CUB 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGGATCTACCTCAATCATCCA	0.373										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	34					0	0	0	0	A	113564847	A	A	113564847	3	1	100	1	0	0	0	0	1	0	0	0	3963	1551	54	5	6970	5	CSMD3	8	113564847	Missense_Mutation	SNP	T	TCGA-CQ-6218-01A-11D-1912-08	20538029	113564847	32799175	67	19175											
FER1L6	654463	broad.mit.edu	37	chr8	125094566	125094566	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacattcccaaaagagtccCtgctctccatcctgatctat	10	11	4	16	0	2	2	0	1	2	1	6	2	5	2	5	0	1	1	5	0	3	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:125094566C>T	uc003yqw.2	+	33	4464	c.4258C>T	c.(4258-4260)CTG>TTG	p.L1420L	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1420	C2 5.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAAAGAGTCCCTGCTCTCCAT	0.488													43	149					0	0	0	0	T	125094566	T	T	125094566	2	4	100	1	0	0	0	0	0	0	0	1	5847	680	24	4		4	FER1L6	8	125094566	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	11529719	125094566	21269456	68	19176											
LRRC6	23639	broad.mit.edu	37	chr8	133622423	133622423	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacctaccttgggcatgcAgatgaccaaatgacccgttg	11	9	10	11	1	0	4	0	3	0	1	0	4	0	4	4	1	2	3	4	1	2	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr8:133622423A>T	uc003ytk.2	-	10	1203	c.1129T>A	c.(1129-1131)TGC>AGC	p.C377S	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	377	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTGGGCATGCAGATGACCAAA	0.433													12	78					0	0	0	0	T	133622423	T	T	133622423	3	4	100	1	0	0	0	0	1	0	0	0	9066	188	7	5	283	5	LRRC6	8	133622423	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	8527857	133622423	12741599	69	19177											
KIAA2026	158358	broad.mit.edu	37	chr9	5922609	5922609	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caatgttgttctgtacctttCtgttgaagtggtggcacttc	6	17	10	8	0	2	1	0	1	2	0	3	1	2	1	1	2	1	5	1	2	3	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:5922609C>T	uc003zjq.3	-	8	3603	c.3387G>A	c.(3385-3387)CAG>CAA	p.Q1129Q	KIAA2026_uc010mht.2_Silent_p.Q304Q	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1129										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CTGTACCTTTCTGTTGAAGTG	0.368													4	83					0	0	0	0	T	5922609	T	T	5922609	2	4	100	1	0	0	0	0	0	0	0	1	8309	912	32	2		2	KIAA2026	9	5922609	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08		5922609	135290822	70	19178											
TRPM3	80036	broad.mit.edu	37	chr9	73457992	73457992	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctatggtgcatatctttcctCgagacttagaggcatgatcc	9	13	9	10	1	1	3	0	1	1	2	4	4	3	3	2	2	1	2	2	2	3	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:73457992C>G	uc004aid.2	-	5	972	c.728G>C	c.(727-729)CGA>CCA	p.R243P	TRPM3_uc004ahu.2_Missense_Mutation_p.R73P|TRPM3_uc004ahv.2_Missense_Mutation_p.R73P|TRPM3_uc004ahw.2_Missense_Mutation_p.R90P|TRPM3_uc004ahx.2_Missense_Mutation_p.R90P|TRPM3_uc004ahy.2_Missense_Mutation_p.R90P|TRPM3_uc004ahz.2_Missense_Mutation_p.R90P|TRPM3_uc004aia.2_Missense_Mutation_p.R90P|TRPM3_uc004aib.2_Missense_Mutation_p.R90P|TRPM3_uc004aic.2_Missense_Mutation_p.R243P|TRPM3_uc010mor.2_Missense_Mutation_p.R243P|TRPM3_uc004aie.2_Missense_Mutation_p.R90P|TRPM3_uc004aif.2_Missense_Mutation_p.R90P|TRPM3_uc004aig.2_Missense_Mutation_p.R90P|TRPM3_uc004aii.2_Missense_Mutation_p.R245P	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	243	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TATCTTTCCTCGAGACTTAGA	0.423													7	38					0	0	0	0	G	73457992	G	G	73457992	3	3	100	1	0	0	0	0	1	0	0	0	16654	884	31	3	4602	3	TRPM3	9	73457992	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	67535383	73457992	67755439	71	19179											
TRPM6	140803	broad.mit.edu	37	chr9	77377455	77377455	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagaacctcagtctggatgtCctgttcagttgccagcacat	10	11	9	11	0	3	1	2	0	1	1	4	2	4	2	3	1	3	3	3	1	2	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:77377455C>T	uc004ajl.1	-	26	4370	c.4132G>A	c.(4132-4134)GAC>AAC	p.D1378N	TRPM6_uc004ajk.1_Missense_Mutation_p.D1373N|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.D334N	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1378	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTCTGGATGTCCTGTTCAGTT	0.512													26	89					0	0	0	0	T	77377455	T	T	77377455	3	4	100	1	0	0	0	0	1	0	0	0	16657	855	30	2	1992	2	TRPM6	9	77377455	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	3919463	77377455	63835976	72	19180											
C9orf3	84909	broad.mit.edu	37	chr9	97522832	97522832	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aactaaacctgaagggcgatCggttacatggacctcagacc	13	7	10	11	2	1	2	1	1	0	1	2	4	1	3	3	3	3	1	3	3	5	2	rs145414026		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:97522832C>T	uc004ava.2	+	1	902	c.767C>T	c.(766-768)TCG>TTG	p.S256L	C9orf3_uc011lui.1_RNA|C9orf3_uc004aux.1_Missense_Mutation_p.S256L|C9orf3_uc004auy.2_Missense_Mutation_p.S256L|C9orf3_uc004auz.1_Missense_Mutation_p.S256L	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	256					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		GAAGGGCGATCGGTTACATGG	0.488													5	18					0	0	0	0	T	97522832	T	T	97522832	3	4	100	1	0	0	0	0	1	0	0	0	2489	893	31	1	769	1	C9orf3	9	97522832	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	20145377	97522832	43690599	73	19181											
DBC1	1620	broad.mit.edu	37	chr9	121929788	121929788	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtaggtagccgagtccgactAcgtaggtagatgtggaccgt	9	9	15	8	4	0	1	0	0	0	1	1	4	1	2	3	3	2	4	3	3	5	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:121929788A>T	uc004bkc.2	-	8	2316	c.1860T>A	c.(1858-1860)CGT>CGA	p.R620R		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	620					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GAGTCCGACTACGTAGGTAGA	0.537													33	107					0	0	0	0	T	121929788	T	T	121929788	2	4	100	1	0	0	0	0	0	0	0	1	4264	378	14	5		5	DBC1	9	121929788	Silent	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	24406956	121929788	19283643	74	19182											
OBP2A	29991	broad.mit.edu	37	chr9	138439759	138439759	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcaggagctgcccgggaCggacgactacgtcttttact	7	9	12	13	4	1	0	0	0	1	0	1	4	1	3	2	3	5	2	2	3	2	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:138439759C>T	uc004cgb.2	+	4	362	c.320C>T	c.(319-321)ACG>ATG	p.T107M	OBP2A_uc004cgc.2_Missense_Mutation_p.T107M|OBP2A_uc010nau.2_RNA|OBP2A_uc010nav.2_Silent_p.D62D	NM_014582	NP_055397	Q9NY56	OBP2A_HUMAN	odorant binding protein 2A precursor	107					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		CTGCCCGGGACGGACGACTAC	0.607													10	26					0	0	0	0	T	138439759	T	T	138439759	3	4	100	1	0	0	0	0	1	0	0	0	10864	536	19	1	334	1	OBP2A	9	138439759	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	16509971	138439759	2773672	75	19183											
PNPLA7	375775	broad.mit.edu	37	chr9	140437130	140437130	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctccagccgcccgtcctgCaccacacagatgctggggtc	7	6	10	18	2	0	1	0	0	0	1	3	1	2	1	6	2	3	2	6	2	0	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr9:140437130C>T	uc004cnf.2	-	6	892	c.555G>A	c.(553-555)GTG>GTA	p.V185V	PNPLA7_uc010ncj.1_Silent_p.V210V	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	185	cNMP 1.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GCCCGTCCTGCACCACACAGA	0.642													17	40					0	0	0	0	T	140437130	T	T	140437130	2	4	100	1	0	0	0	0	0	0	0	1	12225	697	25	4		4	PNPLA7	9	140437130	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	1997371	140437130	776301	76	19184											
KIF5B	3799	broad.mit.edu	37	chr10	32329357	32329357	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatgtttgtccatatgcaaaTattgttccattatatccttc	10	18	5	8	0	0	0	0	0	0	0	4	1	3	0	3	0	1	3	3	0	5	8	rs147256984		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:32329357T>C	uc001iwe.3	-	3	713	c.243A>G	c.(241-243)ATA>ATG	p.I81M		NM_004521	NP_004512	P33176	KINH_HUMAN	kinesin family member 5B	81	Kinesin-motor.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)				CATATGCAAATATTGTTCCAT	0.328													13	43					0	0	0	0	C	32329357	C	C	32329357	3	2	100	1	0	0	0	0	1	0	0	0	8345	1396	49	5	2740	5	KIF5B	10	32329357	Missense_Mutation	SNP	T	TCGA-CQ-6218-01A-11D-1912-08		32329357	103205390	77	19185											
POLR3A	11128	broad.mit.edu	37	chr10	79737376	79737376	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattcccatgatgatgcactCagacacccctgaaaccaacc	13	7	6	15	0	1	4	1	3	0	1	2	5	2	4	5	0	3	1	5	0	2	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:79737376C>A	uc001jzn.2	-	31	4127	c.4033G>T	c.(4033-4035)GAG>TAG	p.E1345*		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	1345					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			ATGATGCACTCAGACACCCCT	0.423													17	59					0.00074312	0.00096121	1	0	A	79737376	A	A	79737376	4	1	100	1	0	0	0	0	0	1	0	0	12283	835	29	2	143	2	POLR3A	10	79737376	Nonsense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	47408019	79737376	55797371	78	19186											
GRID1	2894	broad.mit.edu	37	chr10	87898641	87898641	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcgcggcgaagcgtgtcccGgtagcgattcagctcctctg	5	8	15	13	6	2	0	1	0	1	0	4	2	4	0	2	3	3	2	2	3	2	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:87898641G>A	uc001kdl.1	-	4	762	c.661C>T	c.(661-663)CGG>TGG	p.R221W	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	221	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGCGTGTCCCGGTAGCGATTC	0.592										Multiple Myeloma(13;0.14)			41	133					0	0	0	0	A	87898641	A	A	87898641	3	1	100	1	0	0	0	0	1	0	0	0	6810	1115	39	1	2420	1	GRID1	10	87898641	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	8161265	87898641	47636106	79	19187											
AGAP11	119385	broad.mit.edu	37	chr10	88768495	88768495	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaagcttaggtgattatatGaagaatattcataaaaaaga	19	12	7	3	0	2	4	2	2	0	2	2	4	2	4	0	1	1	1	0	1	10	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:88768495G>A	uc001kee.2	+	12	1690	c.486G>A	c.(484-486)ATG>ATA	p.M162I	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	162	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						GTGATTATATGAAGAATATTC	0.443													55	197					0	0	0	0	A	88768495	A	A	88768495	3	1	100	1	0	0	0	0	1	0	0	0	367	1290	45	2	500	2	AGAP11	10	88768495	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	869854	88768495	46766252	80	19188											
CHUK	1147	broad.mit.edu	37	chr10	101953836	101953836	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgatattactgagggccaCttccaccttagggagtagat	10	13	10	8	0	0	3	0	2	0	1	1	4	1	4	3	2	1	1	3	2	4	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:101953836C>A	uc001kqp.2	-	18	1934	c.1879G>T	c.(1879-1881)GTG>TTG	p.V627L		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	627					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		CTGAGGGCCACTTCCACCTTA	0.423													13	52					0.00010058	0.000132254	1	0	A	101953836	A	A	101953836	3	1	100	1	0	0	0	0	1	0	0	0	3431	565	20	4	374	4	CHUK	10	101953836	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	13185341	101953836	33580911	81	19189											
ABLIM1	3983	broad.mit.edu	37	chr10	116251550	116251550	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcttgagtccacctcacCttgaagatacatttcctctc	8	15	5	13	0	3	3	1	2	2	1	6	3	5	3	4	0	1	1	4	0	2	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:116251550C>T	uc010qsg.1	-	7	1081	c.982G>A	c.(982-984)GGC>AGC	p.G328S	ABLIM1_uc010qsh.1_Missense_Mutation_p.G268S|ABLIM1_uc010qsi.1_Missense_Mutation_p.G268S|ABLIM1_uc010qsk.1_Missense_Mutation_p.G252S|ABLIM1_uc009xyp.2_Missense_Mutation_p.G262S|ABLIM1_uc010qsf.1_Missense_Mutation_p.G12S|ABLIM1_uc009xyn.2_Missense_Mutation_p.G5S|ABLIM1_uc010qsj.1_Missense_Mutation_p.G5S|ABLIM1_uc009xyo.2_Missense_Mutation_p.G176S	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	328	LIM zinc-binding 4.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		TCCACCTCACCTTGAAGATAC	0.438													25	94					0	0	0	0	T	116251550	T	T	116251550	3	4	100	1	0	0	0	0	1	0	0	0	94	695	24	4	1506	4	ABLIM1	10	116251550	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	14297714	116251550	19283197	82	19190											
KCNK18	338567	broad.mit.edu	37	chr10	118969311	118969311	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaacttggcacatgtccttCacgcccaagctgcagcatgg	10	8	9	14	1	1	0	1	0	0	0	2	0	2	0	2	2	4	4	2	2	2	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:118969311C>G	uc010qsr.1	+	3	656	c.656C>G	c.(655-657)TCA>TGA	p.S219*		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	219	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		ACATGTCCTTCACGCCCAAGC	0.532													14	51					0	0	0	0	G	118969311	G	G	118969311	4	3	100	1	0	0	0	0	0	1	0	0	8104	838	29	2	666	2	KCNK18	10	118969311	Nonsense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	2717761	118969311	16565436	83	19191											
PDZD8	118987	broad.mit.edu	37	chr10	119043299	119043299	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttggaccacagacctccGtgtcactgccttcgttgtct	5	14	9	13	2	2	1	1	0	1	1	4	2	3	2	4	1	1	2	4	1	0	3	rs148717941		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr10:119043299G>A	uc001lde.1	-	5	3144	c.2945C>T	c.(2944-2946)ACG>ATG	p.T982M		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	982					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		ACAGACCTCCGTGTCACTGCC	0.478													79	257					0	0	0	0	A	119043299	A	A	119043299	3	1	100	1	0	0	0	0	1	0	0	0	11759	1145	40	1	523	1	PDZD8	10	119043299	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	73988	119043299	16491448	84	19192											
IRF7	3665	broad.mit.edu	37	chr11	613301	613301	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcggagcctgggggtccgCccacctcccagtacaccttg	5	7	13	16	2	0	0	0	0	0	0	2	1	2	1	6	4	2	1	6	4	1	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:613301C>T	uc001lqh.2	-	9	1512	c.1142G>A	c.(1141-1143)GGC>GAC	p.G381D	IRF7_uc009ycb.2_Missense_Mutation_p.G275D|IRF7_uc010qwf.1_Missense_Mutation_p.G380D|IRF7_uc001lqf.2_Missense_Mutation_p.G88D|IRF7_uc010qwg.1_Missense_Mutation_p.G88D|IRF7_uc001lqg.2_Missense_Mutation_p.G394D|IRF7_uc001lqi.2_Missense_Mutation_p.G352D|IRF7_uc010qwh.1_Missense_Mutation_p.G88D	NM_001572	NP_001563	Q92985	IRF7_HUMAN	interferon regulatory factor 7 isoform a	381					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGGGGTCCGCCCACCTCCCA	0.672													7	27					0	0	0	0	T	613301	T	T	613301	3	4	100	1	0	0	0	0	1	0	0	0	7874	739	26	4	381	4	IRF7	11	613301	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08		613301	134393215	85	19193											
OR51Q1	390061	broad.mit.edu	37	chr11	5444060	5444060	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgccttgctcattattatCgtggatcctctgctcattgt	5	18	7	11	1	3	0	2	0	1	0	5	1	4	1	2	1	3	2	2	1	2	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:5444060C>T	uc010qzd.1	+	1	630	c.630C>T	c.(628-630)ATC>ATT	p.I210I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCATTATTATCGTGGATCCTC	0.502													39	119					0	0	0	0	T	5444060	T	T	5444060	2	4	100	1	0	0	0	0	0	0	0	1	11158	874	31	1		1	OR51Q1	11	5444060	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	4830759	5444060	129562456	86	19194											
DNHD1	144132	broad.mit.edu	37	chr11	6588430	6588430	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcatgaagccacgtgagatTaatcacggggaggacctggc	12	6	14	9	2	1	2	1	2	0	1	1	5	1	4	2	4	2	1	2	4	2	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:6588430T>G	uc001mdw.3	+	36	12255	c.11691T>G	c.(11689-11691)ATT>ATG	p.I3897M	DNHD1_uc001mea.3_Missense_Mutation_p.I166M|DNHD1_uc001meb.2_Missense_Mutation_p.I165M|DNHD1_uc001mec.2_Missense_Mutation_p.I165M|DNHD1_uc010rao.1_Missense_Mutation_p.I155M|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	3897					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CACGTGAGATTAATCACGGGG	0.572													35	89					0	0	0	0	G	6588430	G	G	6588430	3	3	100	1	0	0	0	0	1	0	0	0	4690	1742	61	5	11834	5	DNHD1	11	6588430	Missense_Mutation	SNP	T	TCGA-CQ-6218-01A-11D-1912-08	1144370	6588430	128418086	87	19195											
TMEM41B	440026	broad.mit.edu	37	chr11	9321190	9321190	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaaaagctgcagataagaaAatggacaccaatataaggag	21	5	9	6	0	0	2	0	0	0	2	0	4	0	4	1	2	2	2	1	2	8	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:9321190A>G	uc001mhm.2	-	2	488	c.180T>C	c.(178-180)ATT>ATC	p.I60I	TMEM41B_uc001mhn.1_Silent_p.I60I	NM_015012	NP_055827	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B isoform 1	60	Helical; (Potential).					integral to membrane					0				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		CAGATAAGAAAATGGACACCA	0.299													11	42					0	0	0	0	G	9321190	G	G	9321190	2	3	100	1	0	0	0	0	0	0	0	1	16231	10	1	5		5	TMEM41B	11	9321190	Silent	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	2732760	9321190	125685326	88	19196											
CD82	3732	broad.mit.edu	37	chr11	44640601	44640601	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccgcctctccccacagctCctggggatggtcctgtccat	4	10	9	18	1	1	0	0	0	1	0	6	1	5	1	7	3	1	1	7	3	0	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:44640601C>A	uc001myc.2	+	10	977	c.729C>A	c.(727-729)CTC>CTA	p.L243L	CD82_uc001myd.2_Silent_p.L218L	NM_002231	NP_002222	P27701	CD82_HUMAN	CD82 antigen isoform 1	243	Helical; (Potential).					integral to plasma membrane	protein binding			ovary(1)	1						CCCCACAGCTCCTGGGGATGG	0.557													14	57					6.94344e-10	9.38943e-10	1	0	A	44640601	A	A	44640601	2	1	100	1	0	0	0	0	0	0	0	1	3055	842	30	2		2	CD82	11	44640601	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	35319411	44640601	90365915	89	19197											
ATG2A	23130	broad.mit.edu	37	chr11	64679357	64679357	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccggcgggaggccatgtcGctgcgcacagaggaggccag	8	3	18	12	4	0	1	0	0	0	1	1	3	0	3	3	5	2	2	3	5	0	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:64679357G>A	uc001obx.2	-	9	1300	c.1185C>T	c.(1183-1185)AGC>AGT	p.S395S		NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	395							protein binding			ovary(1)|central_nervous_system(1)	2						AGGCCATGTCGCTGCGCACAG	0.637													5	24					0	0	0	0	A	64679357	A	A	64679357	2	1	100	1	0	0	0	0	0	0	0	1	1095	1078	38	1		1	ATG2A	11	64679357	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	20038756	64679357	70327159	90	19198											
PCNXL3	399909	broad.mit.edu	37	chr11	65397860	65397860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgaggtggaggctatcaccGagggtgtggaggaggacgag	9	5	21	6	3	1	0	1	0	0	0	1	7	1	4	1	7	0	1	1	7	1	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:65397860G>A	uc001oey.2	+	27	4255	c.4255G>A	c.(4255-4257)GAG>AAG	p.E1419K	PCNXL3_uc001oez.2_Missense_Mutation_p.E306K	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1419						integral to membrane					0						GGCTATCACCGAGGGTGTGGA	0.637													24	67					0	0	0	0	A	65397860	A	A	65397860	3	1	100	1	0	0	0	0	1	0	0	0	11647	1059	37	1	4361	1	PCNXL3	11	65397860	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	718503	65397860	69608656	91	19199											
SUV420H1	51111	broad.mit.edu	37	chr11	67925548	67925548	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agctttgctacatagagattGttatcgttgtcatggtcttt	8	18	9	6	1	2	1	1	0	1	1	3	2	2	1	0	1	3	4	0	1	3	7			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:67925548G>A	uc001onm.1	-	11	2521	c.2265C>T	c.(2263-2265)AAC>AAT	p.N755N	SUV420H1_uc009yse.1_Silent_p.N341N|SUV420H1_uc001onn.1_Silent_p.N583N|SUV420H1_uc009ysf.2_Silent_p.N515N	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	755					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CATAGAGATTGTTATCGTTGT	0.368													58	152					0	0	0	0	A	67925548	A	A	67925548	2	1	100	1	0	0	0	0	0	0	0	1	15480	1368	48	4		4	SUV420H1	11	67925548	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	2527688	67925548	67080968	92	19200											
CWF19L2	143884	broad.mit.edu	37	chr11	107197637	107197637	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaaaatggaaggtacacctCaatagtttttacttttggtg	12	16	8	5	0	1	0	1	0	0	0	1	1	1	1	1	3	2	2	1	3	7	8			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr11:107197637C>T	uc010rvp.1	-	18	2714	c.2684G>A	c.(2683-2685)TGA>TAA	p.*895*	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	895							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		AGGTACACCTCAATAGTTTTT	0.408													11	42					0	0	0	0	T	107197637	T	T	107197637	2	4	100	1	0	0	0	0	0	0	0	1	4089	837	29	2		2	CWF19L2	11	107197637	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	39272089	107197637	27808879	93	19201											
GRIN2B	2904	broad.mit.edu	37	chr12	13715886	13715886	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgaagggccgagaccaccGgcttgttggtgacaagggcc	9	6	15	11	2	0	3	0	2	0	1	0	4	0	3	4	4	0	2	4	4	2	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:13715886G>A	uc001rbt.2	-	13	4465	c.4286C>T	c.(4285-4287)CCG>CTG	p.P1429L		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1429	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGAGACCACCGGCTTGTTGGT	0.607													16	54					0	0	0	0	A	13715886	A	A	13715886	3	1	100	1	0	0	0	0	1	0	0	0	6819	1116	39	1	172	1	GRIN2B	12	13715886	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		13715886	120136009	94	19202											
PUS7L	83448	broad.mit.edu	37	chr12	44148421	44148421	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaatgcttcctcttcagataCcaaatgacaaagttctttat	14	14	4	9	0	3	2	1	1	2	1	4	2	4	2	2	0	2	2	2	0	5	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:44148421C>G	uc001rnq.3	-	2	1117	c.628G>C	c.(628-630)GTA>CTA	p.V210L	PUS7L_uc001rnr.3_Missense_Mutation_p.V210L|PUS7L_uc001rns.3_Missense_Mutation_p.V210L|PUS7L_uc009zkb.2_Intron	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	210					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TCTTCAGATACCAAATGACAA	0.299													4	24					0	0	0	0	G	44148421	G	G	44148421	3	3	100	1	0	0	0	0	1	0	0	0	12899	507	18	4	1509	4	PUS7L	12	44148421	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	30432535	44148421	89703474	95	19203											
KRT74	121391	broad.mit.edu	37	chr12	52965209	52965209	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccactttggcctgaagctcCaccttgactgcgtaggctgc	6	11	10	14	1	0	2	0	2	0	0	2	2	2	2	4	2	3	3	4	2	2	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:52965209C>A	uc001sap.1	-	4	825	c.777G>T	c.(775-777)GTG>GTT	p.V259V		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	259	Coil 1B.|Rod.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		CCTGAAGCTCCACCTTGACTG	0.567													16	54					1.99824e-07	2.6718e-07	1	0	A	52965209	A	A	52965209	2	1	100	1	0	0	0	0	0	0	0	1	8526	581	21	4		4	KRT74	12	52965209	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	8816788	52965209	80886686	96	19204											
COPZ1	22818	broad.mit.edu	37	chr12	54718955	54718956	+	In_Frame_Ins	INS	-	GCG	GCG																															ctgcggggcaagatggaggcINSgctgattttggtaggagctg																										TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:54718955_54718956insGCG	uc001sfs.1	+	1	45_46	c.8_9insGCG	c.(7-9)GCG>GCGCGG	p.3_4insR	COPZ1_uc001sft.2_5'UTR|COPZ1_uc009znm.1_5'UTR|COPZ1_uc010sot.1_In_Frame_Ins_p.3_4insR	NM_016057	NP_057141	P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	3_4					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol					0						AAGATGGAGGCGCTGATTTTGG	0.619											OREG0021891	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								GCG	54718956	GCG	GCG	54718955	7	5	100	1	0	1	1	0	0	0	0	0	3756	768	27	0	10	0	COPZ1	12	54718955	In_Frame_Ins	INS	-	TCGA-CQ-6218-01A-11D-1912-08	1753746	54718955	79132940	97	19205											
TRHDE	29953	broad.mit.edu	37	chr12	72955951	72955951	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttatattcttgtaggattatTtaaccattcataagtatggt	12	19	6	4	0	2	0	1	0	1	0	2	1	2	1	1	2	1	2	1	2	7	11			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:72955951T>G	uc001sxa.2	+	8	1690	c.1660T>G	c.(1660-1662)TTA>GTA	p.L554V		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	554	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GTAGGATTATTTAACCATTCA	0.274													4	14					0	0	0	0	G	72955951	G	G	72955951	3	3	100	1	0	0	0	0	1	0	0	0	16546	1838	64	5	1690	5	TRHDE	12	72955951	Missense_Mutation	SNP	T	TCGA-CQ-6218-01A-11D-1912-08	18236996	72955951	60895944	98	19206											
GPR133	283383	broad.mit.edu	37	chr12	131476850	131476850	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaaaccttccaaagtccCggagtgatactgagttacct	14	9	8	10	1	0	3	0	2	0	1	2	4	2	4	4	1	3	1	4	1	5	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:131476850C>T	uc001uit.3	+	8	1438	c.879C>T	c.(877-879)CCC>CCT	p.P293P	GPR133_uc010tbm.1_Silent_p.P325P	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	293	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TCCAAAGTCCCGGAGTGATAC	0.458													45	129					0	0	0	0	T	131476850	T	T	131476850	2	4	100	1	0	0	0	0	0	0	0	1	6681	639	23	1		1	GPR133	12	131476850	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	58520899	131476850	2375045	99	19207											
MMP17	4326	broad.mit.edu	37	chr12	132323155	132323155	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctccatgctttccctgcAgacgaggccaccctggccct	6	8	10	17	1	0	1	0	0	0	1	2	3	2	1	5	2	3	3	5	2	0	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr12:132323155A>G	uc001ujc.1	+	3	392	c.293_splice	c.e3-2	p.D98_splice	MMP17_uc001ujd.1_Splice_Site_p.D14_splice	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein						proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		CTTTCCCTGCAGACGAGGCCA	0.667													4	13					0	0	0	0	G	132323155	G	G	132323155	5	3	100	1	0	0	0	0	0	0	1	0	9709	202	7	5	301	5	MMP17	12	132323155	Splice_Site	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	846305	132323155	1528740	100	19208											
FAM123A	219287	broad.mit.edu	37	chr13	25744231	25744231	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcctgctgctccttctcCgggtgcttgggctcctcctt	0	15	9	17	1	1	0	0	0	1	0	6	0	5	0	6	2	3	4	6	2	0	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr13:25744231C>T	uc001uqb.2	-	1	1627	c.1527G>A	c.(1525-1527)CCG>CCA	p.P509P	FAM123A_uc001uqa.2_Silent_p.P390P|FAM123A_uc001uqc.2_Silent_p.P390P	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	509										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GCTCCTTCTCCGGGTGCTTGG	0.652													18	65					0	0	0	0	T	25744231	T	T	25744231	2	4	100	1	0	0	0	0	0	0	0	1	5450	639	23	1		1	FAM123A	13	25744231	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08		25744231	89425647	101	19209											
ATP8A2	51761	broad.mit.edu	37	chr13	26104781	26104781	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taacaattgcaggcatcaaaGagattgtagaagattttgta	16	12	9	4	0	1	3	1	0	0	3	1	4	1	3	0	1	2	4	0	1	6	7			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr13:26104781G>A	uc001uqk.2	+	4	545	c.403G>A	c.(403-405)GAG>AAG	p.E135K	ATP8A2_uc010tdi.1_Missense_Mutation_p.E95K|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.E95K	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	95	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGGCATCAAAGAGATTGTAGA	0.353													4	16					0	0	0	0	A	26104781	A	A	26104781	3	1	100	1	0	0	0	0	1	0	0	0	1195	943	33	2	417	2	ATP8A2	13	26104781	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	360550	26104781	89065097	102	19210											
CHD8	57680	broad.mit.edu	37	chr14	21881157	21881157	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gattaaagggctcttcatccTagatgagttaggaaaccaaa	15	10	9	7	0	2	2	1	1	1	1	3	4	3	3	2	2	1	2	2	2	6	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr14:21881157T>C	uc001was.1	-	10	1400	c.1306_splice	c.e10-1	p.D436_splice	CHD8_uc001war.1_Splice_Site_p.D332_splice	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8						ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CTCTTCATCCTAGATGAGTTA	0.323													6	20					0	0	0	0	C	21881157	C	C	21881157	5	2	100	1	0	0	0	0	0	0	1	0	3346	1536	53	5	5720	5	CHD8	14	21881157	Splice_Site	SNP	T	TCGA-CQ-6218-01A-11D-1912-08		21881157	85468383	103	19211											
DHRS7	51635	broad.mit.edu	37	chr14	60616104	60616104	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagttctcaatccttttcttCcccatcttgttggttatcca	7	18	4	12	0	3	0	1	0	3	0	7	0	6	0	4	1	0	3	4	1	3	7			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr14:60616104C>T	uc001xes.2	-	6	1123	c.939G>A	c.(937-939)GGG>GGA	p.G313G	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Silent_p.G263G|DHRS7_uc001xeu.2_Silent_p.G313G	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	313							binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		TCCTTTTCTTCCCCATCTTGT	0.383													15	56					0	0	0	0	T	60616104	T	T	60616104	2	4	100	1	0	0	0	0	0	0	0	1	4517	842	30	2		2	DHRS7	14	60616104	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	38734947	60616104	46733436	104	19212											
SYNE2	23224	broad.mit.edu	37	chr14	64518705	64518705	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctgaacttcagatgaagAggatttggggagaaaaagaa	18	7	13	3	0	1	6	1	2	0	4	1	8	1	7	0	3	2	1	0	3	6	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr14:64518705A>G	uc001xgm.2	+	48	8304	c.8074A>G	c.(8074-8076)AGG>GGG	p.R2692G	SYNE2_uc001xgl.2_Missense_Mutation_p.R2692G	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2692	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCAGATGAAGAGGATTTGGGG	0.418													15	87					0	0	0	0	G	64518705	G	G	64518705	3	3	100	1	0	0	0	0	1	0	0	0	15512	295	11	5	8260	5	SYNE2	14	64518705	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	3902601	64518705	42830835	105	19213											
ATG2B	55102	broad.mit.edu	37	chr14	96756776	96756776	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcagtctaaaaagatacctgTatggtttgaaccattctgtt	12	14	8	7	0	2	2	0	1	2	1	2	2	2	2	2	1	2	4	2	1	6	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr14:96756776T>C	uc001yfi.2	-	40	6218	c.5853A>G	c.(5851-5853)ATA>ATG	p.I1951M		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1951										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AAGATACCTGTATGGTTTGAA	0.423													23	65					0	0	0	0	C	96756776	C	C	96756776	3	2	100	1	0	0	0	0	1	0	0	0	1096	1628	57	5	395	5	ATG2B	14	96756776	Missense_Mutation	SNP	T	TCGA-CQ-6218-01A-11D-1912-08	32238071	96756776	10592764	106	19214											
SPESP1	246777	broad.mit.edu	37	chr15	69238803	69238803	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtaattctagatctaaactCtatgaatatttagatattaa	16	17	4	4	0	3	3	0	1	3	2	3	3	3	3	0	0	1	1	0	0	10	10			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr15:69238803C>G	uc002arn.1	+	2	1058	c.930C>G	c.(928-930)CTC>CTG	p.L310L	NOX5_uc002arp.1_Intron|NOX5_uc002arq.1_Intron|NOX5_uc010bid.1_Intron|NOX5_uc002aro.2_Intron	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	310					multicellular organismal development	acrosomal vesicle					0						GATCTAAACTCTATGAATATT	0.318													15	42					0	0	0	0	G	69238803	G	G	69238803	2	3	100	1	0	0	0	0	0	0	0	1	15106	900	32	2		2	SPESP1	15	69238803	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08		69238803	33292589	107	19215											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84651117	84651117	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcagacaagggaagagaagCgtattaacctgaccattggt	14	9	11	7	1	1	3	1	1	0	2	1	5	1	4	2	2	2	1	2	2	5	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr15:84651117C>T	uc002bjz.3	+	21	2961	c.2737C>T	c.(2737-2739)CGT>TGT	p.R913C	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.R913C|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.R913C	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	913	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGAAGAGAAGCGTATTAACCT	0.473													18	84					0	0	0	0	T	84651117	T	T	84651117	3	4	100	1	0	0	0	0	1	0	0	0	276	768	27	1	2815	1	ADAMTSL3	15	84651117	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	15412314	84651117	17880275	108	19216											
NTRK3	4916	broad.mit.edu	37	chr15	88799155	88799155	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatggaagtgatattccttGagatgtccgtgatgttgata	11	14	11	5	1	0	4	0	4	0	1	2	6	2	5	2	1	0	1	2	1	3	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr15:88799155G>C	uc002bme.1	-	2	392	c.230C>G	c.(229-231)TCA>TGA	p.S77*	NTRK3_uc002bmh.2_Nonsense_Mutation_p.S77*|NTRK3_uc002bmf.1_Nonsense_Mutation_p.S77*|NTRK3_uc010bnh.1_Nonsense_Mutation_p.S77*|NTRK3_uc002bmg.2_Nonsense_Mutation_p.S77*	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	77	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			GATATTCCTTGAGATGTCCGT	0.547			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			19	60					0	0	0	0	C	88799155	C	C	88799155	4	2	100	1	0	0	0	0	0	1	0	0	10762	1294	45	2	2623	2	NTRK3	15	88799155	Nonsense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	4148038	88799155	13732237	109	19217											
ZNF710	374655	broad.mit.edu	37	chr15	90611533	90611533	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacttctgcggccgcggcttCgcctaccccagcgagctcaa	6	7	10	18	5	2	0	1	0	1	0	3	1	2	0	4	2	4	2	4	2	2	3	rs144375764		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr15:90611533C>T	uc002bov.1	+	2	1287	c.1164C>T	c.(1162-1164)TTC>TTT	p.F388F		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	388	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			GCCGCGGCTTCGCCTACCCCA	0.642													13	46					0	0	0	0	T	90611533	T	T	90611533	2	4	100	1	0	0	0	0	0	0	0	1	18182	883	31	1		1	ZNF710	15	90611533	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	1812378	90611533	11919859	110	19218											
PDILT	204474	broad.mit.edu	37	chr16	20371931	20371931	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttttgatgtggctttccaGgaagtcagagaagcccttca	10	12	11	8	0	2	2	2	1	0	1	3	4	3	3	2	2	1	2	2	2	2	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr16:20371931G>A	uc002dhc.1	-	11	1688	c.1465C>T	c.(1465-1467)CTG>TTG	p.L489L		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	489					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TGGCTTTCCAGGAAGTCAGAG	0.473													50	190					0	0	0	0	A	20371931	A	A	20371931	2	1	100	1	0	0	0	0	0	0	0	1	11728	991	35	4		4	PDILT	16	20371931	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		20371931	69982822	111	19219											
TNRC6A	27327	broad.mit.edu	37	chr16	24801451	24801451	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcctcagatgcaggctccAtcaggtatgaatggcacttc	10	10	9	12	0	2	2	2	1	0	1	5	2	4	2	2	3	1	4	2	3	2	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr16:24801451A>T	uc002dmm.2	+	6	1602	c.1488A>T	c.(1486-1488)CCA>CCT	p.P496P	TNRC6A_uc010bxs.2_Silent_p.P243P|TNRC6A_uc010vcc.1_Silent_p.P243P|TNRC6A_uc002dmn.2_Silent_p.P243P|TNRC6A_uc002dmo.2_Silent_p.P243P	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	496	Sufficient for interaction with EIF2C1, EIF2C3 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TGCAGGCTCCATCAGGTATGA	0.473													13	91					0	0	0	0	T	24801451	T	T	24801451	2	4	100	1	0	0	0	0	0	0	0	1	16406	204	8	5		5	TNRC6A	16	24801451	Silent	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	4429520	24801451	65553302	112	19220											
ATP2A1	487	broad.mit.edu	37	chr16	28912067	28912067	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcgaattggcatctttgggGagaacgaggaggtggccgat	9	8	18	6	3	1	1	0	0	1	1	1	6	1	2	1	7	1	1	1	7	2	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr16:28912067G>A	uc002dro.1	+	15	2114	c.1930G>A	c.(1930-1932)GAG>AAG	p.E644K	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.E644K|ATP2A1_uc002drp.1_Missense_Mutation_p.E519K	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	644	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CATCTTTGGGGAGAACGAGGA	0.642													15	64					0	0	0	0	A	28912067	A	A	28912067	3	1	100	1	0	0	0	0	1	0	0	0	1138	1175	41	2	1988	2	ATP2A1	16	28912067	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	4110616	28912067	61442686	113	19221											
WSCD1	23302	broad.mit.edu	37	chr17	5993711	5993711	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accggctgccagcggtgagcGtggggctggaagagtgtaac	8	6	18	9	3	0	2	0	1	0	1	0	3	0	3	2	5	4	3	2	5	2	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:5993711G>A	uc010cli.2	+	4	992	c.613G>A	c.(613-615)GTG>ATG	p.V205M	WSCD1_uc002gcn.2_Missense_Mutation_p.V205M|WSCD1_uc002gco.2_Missense_Mutation_p.V205M|WSCD1_uc010clj.2_Translation_Start_Site	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	205	WSC 1.					integral to membrane	sulfotransferase activity				0						AGCGGTGAGCGTGGGGCTGGA	0.662													17	59					0	0	0	0	A	5993711	A	A	5993711	3	1	100	1	0	0	0	0	1	0	0	0	17474	1145	40	1	623	1	WSCD1	17	5993711	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		5993711	75201499	114	19222											
TP53	7157	broad.mit.edu	37	chr17	7578196	7578196	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaggcggctcatagggcAccaccacactatgtcgaaaa	12	6	9	14	2	2	0	2	0	0	0	3	1	2	0	3	3	0	2	3	3	4	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:7578196A>C	uc002gim.2	-	6	847	c.653T>G	c.(652-654)GTG>GGG	p.V218G	TP53_uc002gig.1_Missense_Mutation_p.V218G|TP53_uc002gih.2_Missense_Mutation_p.V218G|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V86G|TP53_uc010cng.1_Missense_Mutation_p.V86G|TP53_uc002gii.1_Missense_Mutation_p.V86G|TP53_uc010cnh.1_Missense_Mutation_p.V218G|TP53_uc010cni.1_Missense_Mutation_p.V218G|TP53_uc002gij.2_Missense_Mutation_p.V218G|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.V125G|TP53_uc002gio.2_Missense_Mutation_p.V86G|TP53_uc010vug.1_Missense_Mutation_p.V179G	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	218	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> A (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V218E(8)|p.V218M(7)|p.0?(7)|p.V218G(5)|p.V218del(5)|p.V218A(3)|p.D208fs*1(1)|p.V216fs*28(1)|p.V218fs*26(1)|p.?(1)|p.S215_V218>R(1)|p.T211fs*28(1)|p.V218_P219insX(1)|p.V218L(1)|p.V218V(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.K164_P219del(1)|p.S215fs*27(1)|p.V218_Y220delVPY(1)|p.V216_Y220delVVVPY(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCATAGGGCACCACCACACT	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	26					0	0	0	0	C	7578196	C	C	7578196	3	2	100	1	0	0	0	0	1	0	0	0	16448	159	6	5	641	5	TP53	17	7578196	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	1584485	7578196	73617014	115	19223											
TP53	7157	broad.mit.edu	37	chr17	7578267	7578267	+	Frame_Shift_Del	DEL	A	-	-																															aaatttccttccactcggatAagatgctgaggaggggccag																										TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:7578267delA	uc002gim.2	-	6	776	c.582delT	c.(580-582)CTTfs	p.L194fs	TP53_uc002gig.1_Frame_Shift_Del_p.L194fs|TP53_uc002gih.2_Frame_Shift_Del_p.L194fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.L62fs|TP53_uc010cng.1_Frame_Shift_Del_p.L62fs|TP53_uc002gii.1_Frame_Shift_Del_p.L62fs|TP53_uc010cnh.1_Frame_Shift_Del_p.L194fs|TP53_uc010cni.1_Frame_Shift_Del_p.L194fs|TP53_uc002gij.2_Frame_Shift_Del_p.L194fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.L101fs|TP53_uc002gio.2_Frame_Shift_Del_p.L62fs|TP53_uc010vug.1_Frame_Shift_Del_p.L155fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	194	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> H (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L194R(31)|p.L194F(16)|p.L194P(8)|p.0?(7)|p.L194H(5)|p.L194L(4)|p.A189_V197delAPPQHLIRV(4)|p.L194fs*15(2)|p.K164_P219del(1)|p.I195fs*14(1)|p.L194fs*52(1)|p.L194V(1)|p.I195fs*50(1)|p.L194fs*14(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.L194I(1)|p.I195fs*12(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCACTCGGATAAGATGCTGAG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578267	-	-	7578267	7	5	100	1	0	1	0	1	0	0	0	0	16448	349	13	0	712	0	TP53	17	7578267	Frame_Shift_Del	DEL	A	TCGA-CQ-6218-01A-11D-1912-08	71	7578267	73616943	116	19224											
MYH13	8735	broad.mit.edu	37	chr17	10248895	10248895	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atccacaggaacatcttctcGtagacggctttggccagagc	10	9	10	12	2	2	2	0	0	2	2	4	3	3	3	2	3	2	2	2	3	2	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:10248895G>A	uc002gmk.1	-	14	1392	c.1302C>T	c.(1300-1302)TAC>TAT	p.Y434Y	MYH13_uc010vvf.1_Silent_p.Y109Y	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	434	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						ACATCTTCTCGTAGACGGCTT	0.517													36	125					0	0	0	0	A	10248895	A	A	10248895	2	1	100	1	0	0	0	0	0	0	0	1	10085	1140	40	1		1	MYH13	17	10248895	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	2670628	10248895	70946315	117	19225											
ABHD15	116236	broad.mit.edu	37	chr17	27889938	27889938	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagatacacagcacaggcaCggctgcctcatcgacatccc	11	5	9	16	2	1	1	1	0	0	1	3	2	2	1	2	2	3	4	2	2	1	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:27889938C>A	uc002hed.1	-	2	1112	c.1048G>T	c.(1048-1050)GTG>TTG	p.V350L		NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	350						extracellular region	carboxylesterase activity				0						AGCACAGGCACGGCTGCCTCA	0.582													7	47					0.000673444	0.000875845	1	0	A	27889938	A	A	27889938	3	1	100	1	0	0	0	0	1	0	0	0	81	536	19	3	362	3	ABHD15	17	27889938	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	17641043	27889938	53305272	118	19226											
TMEM132E	124842	broad.mit.edu	37	chr17	32953441	32953441	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacatccccgagcgcctgacGgtgaactggaaggtgcgggc	8	5	16	12	4	0	2	0	2	0	0	1	5	1	3	3	4	3	0	3	4	2	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:32953441G>A	uc002hif.2	+	2	691	c.363G>A	c.(361-363)ACG>ACA	p.T121T		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	121	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		AGCGCCTGACGGTGAACTGGA	0.697													6	25					0	0	0	0	A	32953441	A	A	32953441	2	1	100	1	0	0	0	0	0	0	0	1	16114	1103	39	1		1	TMEM132E	17	32953441	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	5063503	32953441	48241769	119	19227											
CCDC45	90799	broad.mit.edu	37	chr17	62533807	62533807	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgataacacagaatgatgaTgatgttttcttccgggaact	13	13	9	6	1	1	5	0	4	1	1	2	6	2	6	1	1	2	1	1	1	3	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:62533807T>C	uc002jem.2	+	20	2434	c.2376T>C	c.(2374-2376)GAT>GAC	p.D792D	CCDC45_uc002jen.2_RNA|CCDC45_uc010wqb.1_Silent_p.D628D	NM_138363	NP_612372	Q96GE4	CEP95_HUMAN	coiled-coil domain containing 45	792	Potential.					centrosome|spindle pole	protein binding				0	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			AGAATGATGATGATGTTTTCT	0.458													6	27					0	0	0	0	C	62533807	C	C	62533807	2	2	100	1	0	0	0	0	0	0	0	1	2829	1461	51	5		5	CCDC45	17	62533807	Silent	SNP	T	TCGA-CQ-6218-01A-11D-1912-08	29580366	62533807	18661403	120	19228											
CDK3	1018	broad.mit.edu	37	chr17	74001438	74001438	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagactgccctggcccacccGtacttctcatcccctgagcc	7	8	7	19	1	1	2	1	1	1	1	3	2	2	2	6	1	3	1	6	1	2	2	rs150329289		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr17:74001438G>A	uc010dgt.2	+	8	928	c.852G>A	c.(850-852)CCG>CCA	p.P284P	CDK3_uc002jqg.3_Silent_p.P312P	NM_001258	NP_001249	Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	284	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						TGGCCCACCCGTACTTCTCAT	0.582													12	53					0	0	0	0	A	74001438	A	A	74001438	2	1	100	1	0	0	0	0	0	0	0	1	3155	1132	40	1		1	CDK3	17	74001438	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	11467631	74001438	7193772	121	19229											
POTEC	388468	broad.mit.edu	37	chr18	14530502	14530502	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggattgctgttttcagaaGagatttttagcatctgtttt	8	19	9	5	0	2	2	1	0	1	2	2	4	2	3	0	1	2	4	0	1	2	8			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr18:14530502G>C	uc010dln.2	-	6	1560	c.1106C>G	c.(1105-1107)TCT>TGT	p.S369C	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	369	ANK 7.									skin(3)	3						GTTTTCAGAAGAGATTTTTAG	0.189													3	27					0	0	0	0	C	14530502	C	C	14530502	3	2	100	1	0	0	0	0	1	0	0	0	12317	942	33	2	546	2	POTEC	18	14530502	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		14530502	63546746	122	19230											
ROCK1	6093	broad.mit.edu	37	chr18	18622625	18622625	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttaatacttcaggggaaaTataatcaggtgttccaaccg	13	13	8	7	1	2	0	2	0	0	0	3	1	3	1	2	3	2	1	2	3	6	7			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr18:18622625T>C	uc002kte.2	-	7	1662	c.721A>G	c.(721-723)ATT>GTT	p.I241V		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	241	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TCAGGGGAAATATAATCAGGT	0.393													10	32					0	0	0	0	C	18622625	C	C	18622625	3	2	100	1	0	0	0	0	1	0	0	0	13582	1406	49	5	3451	5	ROCK1	18	18622625	Missense_Mutation	SNP	T	TCGA-CQ-6218-01A-11D-1912-08	4092123	18622625	59454623	123	19231											
MIB1	57534	broad.mit.edu	37	chr18	19429197	19429197	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccttctatgattagtaatGattctgaaaccttagaagag	13	14	8	6	0	2	5	0	3	2	2	3	5	3	5	2	0	1	1	2	0	6	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr18:19429197G>C	uc002ktq.2	+	17	2434	c.2434G>C	c.(2434-2436)GAT>CAT	p.D812H	MIB1_uc002ktp.2_Missense_Mutation_p.D451H	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	812					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			GATTAGTAATGATTCTGAAAC	0.348													47	198					0	0	0	0	C	19429197	C	C	19429197	3	2	100	1	0	0	0	0	1	0	0	0	9619	1290	45	2	2500	2	MIB1	18	19429197	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	806572	19429197	58648051	124	19232											
CREB3L3	84699	broad.mit.edu	37	chr19	4164536	4164536	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggcctcctacctcctgcgaCctggggctgggcactgtcag	4	8	14	15	1	1	0	1	0	0	0	3	1	3	0	5	4	2	2	5	4	1	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:4164536C>T	uc002lzl.2	+	5	729	c.613C>T	c.(613-615)CCT>TCT	p.P205S	CREB3L3_uc002lzm.2_Missense_Mutation_p.P195S|CREB3L3_uc010xib.1_Missense_Mutation_p.P194S|CREB3L3_uc010xic.1_Missense_Mutation_p.P196S	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	205	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCCTGCGACCTGGGGCTGG	0.582													19	94					0	0	0	0	T	4164536	T	T	4164536	3	4	100	1	0	0	0	0	1	0	0	0	3873	507	18	4	631	4	CREB3L3	19	4164536	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08		4164536	54964447	125	19233											
KHSRP	8570	broad.mit.edu	37	chr19	6422368	6422368	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctccatcttccaactgtCtcttttggcccccaaaacca	9	12	3	17	0	2	0	0	0	2	0	5	0	4	0	6	1	3	0	6	1	4	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:6422368C>T	uc002mer.3	-	2	439	c.329G>A	c.(328-330)AGA>AAA	p.R110K		NM_003685	NP_003676	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	110	Gly-rich.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			skin(1)	1						TTCCAACTGTCTCTTTTGGCC	0.493													19	96					0	0	0	0	T	6422368	T	T	6422368	3	4	100	1	0	0	0	0	1	0	0	0	8190	913	32	2	1882	2	KHSRP	19	6422368	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	2257832	6422368	52706615	126	19234											
MYO9B	4650	broad.mit.edu	37	chr19	17270248	17270248	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggttctgaccaaaagaaaaaCggtgaccgtcaacgacaagc	16	5	10	10	3	2	3	1	2	1	1	2	4	2	3	2	2	3	1	2	2	6	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:17270248C>T	uc010eak.2	+	8	1525	c.1373C>T	c.(1372-1374)ACG>ATG	p.T458M	MYO9B_uc002nfi.2_Missense_Mutation_p.T458M|MYO9B_uc002nfj.1_Missense_Mutation_p.T458M	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	458	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						AAAAGAAAAACGGTGACCGTC	0.522													6	13					0	0	0	0	T	17270248	T	T	17270248	3	4	100	1	0	0	0	0	1	0	0	0	10138	536	19	1	1399	1	MYO9B	19	17270248	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	10847880	17270248	41858735	127	19235											
ITPKC	80271	broad.mit.edu	37	chr19	41223543	41223543	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagcccctggacacagccagGggttcatgggccctggacag	8	5	14	14	0	1	0	1	0	0	0	1	2	1	2	4	5	2	1	4	5	0	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:41223543G>T	uc002oot.2	+	1	536	c.503G>T	c.(502-504)GGG>GTG	p.G168V	ADCK4_uc002ooq.1_5'Flank|ADCK4_uc002oor.2_5'Flank|ADCK4_uc002oos.2_5'Flank	NM_025194	NP_079470	Q96DU7	IP3KC_HUMAN	inositol 1,4,5-trisphosphate 3-kinase C	168						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			ACACAGCCAGGGGTTCATGGG	0.607													19	40					1.15919e-05	1.5327e-05	1	0	T	41223543	T	T	41223543	3	4	100	1	0	0	0	0	1	0	0	0	7958	1232	43	4	505	4	ITPKC	19	41223543	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	23953295	41223543	17905440	128	19236											
LMTK3	114783	broad.mit.edu	37	chr19	49013282	49013282	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catggcgtggggcagtacctGagtgtgaaggctgcggggca	7	7	19	8	2	0	2	0	2	0	0	0	2	0	2	1	6	2	4	1	6	2	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:49013282G>A	uc002pjk.2	-	4	446	c.446C>T	c.(445-447)TCA>TTA	p.S149L		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGCAGTACCTGAGTGTGAAGG	0.622													10	33					0	0	0	0	A	49013282	A	A	49013282	3	1	100	1	0	0	0	0	1	0	0	0	8902	1294	45	2	4075	2	LMTK3	19	49013282	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	7789739	49013282	10115701	129	19237											
ZNF432	9668	broad.mit.edu	37	chr19	52537191	52537191	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgtaaagcaagctctgtttCcttggcaaagcctcttccac	10	12	7	12	0	2	0	0	0	2	0	4	0	4	0	3	1	3	5	3	1	4	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:52537191C>A	uc002pyk.2	-	5	2059	c.1741G>T	c.(1741-1743)GAA>TAA	p.E581*		NM_014650	NP_055465	O94892	ZN432_HUMAN	zinc finger protein 432	581	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|pancreas(1)	3		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		AGCTCTGTTTCCTTGGCAAAG	0.378													28	63					9.39395e-14	1.30746e-13	1	0	A	52537191	A	A	52537191	4	1	100	1	0	0	0	0	0	1	0	0	17973	864	30	2	221	2	ZNF432	19	52537191	Nonsense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	3523909	52537191	6591792	130	19238											
KIR2DL1	3802	broad.mit.edu	37	chr19	55281317	55281317	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcaccatgtcgctcttggtCgtcagcatggcgtgtgttgg	5	12	14	10	3	2	0	1	0	1	0	4	0	2	0	1	3	2	4	1	3	0	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:55281317C>T	uc002qhb.1	+	1	53	c.15C>T	c.(13-15)GTC>GTT	p.V5V	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_RNA|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Silent_p.V5V	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	5					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		CGCTCTTGGTCGTCAGCATGG	0.602											OREG0003674	type=REGULATORY REGION|Gene=KIR2DL1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	32	37					0	0	0	0	T	55281317	T	T	55281317	2	4	100	1	0	0	0	0	0	0	0	1	8355	871	31	1		1	KIR2DL1	19	55281317	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	2744126	55281317	3847666	131	19239											
PEG3	5178	broad.mit.edu	37	chr19	57326231	57326231	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaccatcatcacaccccttCatggaatacaactggtcttg	13	10	5	13	0	4	0	3	0	1	0	4	1	4	1	3	2	3	0	3	2	4	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:57326231C>A	uc002qnu.2	-	7	3930	c.3579G>T	c.(3577-3579)ATG>ATT	p.M1193I	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.M1164I|PEG3_uc002qnv.2_Missense_Mutation_p.M1193I|PEG3_uc002qnw.2_Missense_Mutation_p.M1069I|PEG3_uc002qnx.2_Missense_Mutation_p.M1067I|PEG3_uc010etr.2_Missense_Mutation_p.M1193I	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1193					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CACACCCCTTCATGGAATACA	0.473													21	93					1.50039e-11	2.06412e-11	1	0	A	57326231	A	A	57326231	3	1	100	1	0	0	0	0	1	0	0	0	11774	826	29	2	1191	2	PEG3	19	57326231	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	2044914	57326231	1802752	132	19240											
USP29	57663	broad.mit.edu	37	chr19	57640945	57640945	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacatgaatgcagttttacAatcgctatttgcaattccat	12	16	5	8	1	0	1	0	1	0	0	2	1	1	1	1	0	4	4	1	0	6	6			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:57640945A>C	uc002qny.2	+	4	1258	c.902A>C	c.(901-903)CAA>CCA	p.Q301P		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	301					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCAGTTTTACAATCGCTATTT	0.448													7	58					0	0	0	0	C	57640945	C	C	57640945	3	2	100	1	0	0	0	0	1	0	0	0	17127	130	5	5	904	5	USP29	19	57640945	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	314714	57640945	1488038	133	19241											
ZNF530	348327	broad.mit.edu	37	chr19	58117555	58117555	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaatccaggaaatcttttaGagagaaatctgtattcattc	14	14	7	6	0	3	3	1	1	2	2	5	5	4	4	1	1	0	1	1	1	5	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:58117555G>C	uc002qpk.2	+	3	882	c.662G>C	c.(661-663)AGA>ACA	p.R221T	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAATCTTTTAGAGAGAAATCT	0.438													3	69					0	0	0	0	C	58117555	C	C	58117555	3	2	100	1	0	0	0	0	1	0	0	0	18038	942	33	2	672	2	ZNF530	19	58117555	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	476610	58117555	1011428	134	19242											
ZSCAN1	284312	broad.mit.edu	37	chr19	58565265	58565265	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccccggagcaagggcccccGggagtccgtcccacccaggg	6	2	14	19	3	0	0	0	0	0	0	2	2	2	2	7	4	1	1	7	4	1	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr19:58565265G>A	uc002qrc.1	+	6	1320	c.1073G>A	c.(1072-1074)CGG>CAG	p.R358Q		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	358					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AAGGGCCCCCGGGAGTCCGTC	0.662													10	37					0	0	0	0	A	58565265	A	A	58565265	3	1	100	1	0	0	0	0	1	0	0	0	18293	1116	39	1	1087	1	ZSCAN1	19	58565265	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	447710	58565265	563718	135	19243											
FAM113A	64773	broad.mit.edu	37	chr20	2819570	2819570	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctcttccagaacatcctcAaggtactcggagtaaacacg	13	8	8	12	2	2	1	1	0	1	1	5	2	4	2	2	2	4	3	2	2	5	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr20:2819570A>C	uc002wgz.1	-	4	860	c.363T>G	c.(361-363)CTT>CTG	p.L121L	FAM113A_uc002whb.1_Intron|FAM113A_uc002wha.1_5'UTR|FAM113A_uc010zqa.1_5'UTR|FAM113A_uc002whc.1_Silent_p.L70L|VPS16_uc002whe.2_5'Flank|VPS16_uc002whf.2_5'Flank|VPS16_uc002whd.2_5'Flank	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773	121							hydrolase activity|protein binding			ovary(2)	2						GAACATCCTCAAGGTACTCGG	0.577													5	94					0	0	0	0	C	2819570	C	C	2819570	2	2	100	1	0	0	0	0	0	0	0	1	5429	117	5	5		5	FAM113A	20	2819570	Silent	SNP	A	TCGA-CQ-6218-01A-11D-1912-08		2819570	60205950	136	19244											
CRLS1	54675	broad.mit.edu	37	chr20	5990553	5990553	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgctttagctggactaacaGatttggtaagttgtaaatgc	11	15	10	5	0	0	1	0	0	0	1	0	2	0	2	0	2	4	5	0	2	5	8	rs59962100		TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr20:5990553G>C	uc002wmn.3	+	2	593	c.439G>C	c.(439-441)GAT>CAT	p.D147H	CRLS1_uc010gbq.2_RNA|CRLS1_uc010gbr.2_Missense_Mutation_p.D48H|CRLS1_uc010gbs.1_Missense_Mutation_p.D36H	NM_019095	NP_061968	Q9UJA2	CRLS1_HUMAN	cardiolipin synthase 1 isoform 1	147	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphotransferase activity, for other substituted phosphate groups				0						TGGACTAACAGATTTGGTAAG	0.413													5	51					0	0	0	0	C	5990553	C	C	5990553	3	2	100	1	0	0	0	0	1	0	0	0	3904	942	33	2	458	2	CRLS1	20	5990553	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	3170983	5990553	57034967	137	19245											
DNTTIP1	116092	broad.mit.edu	37	chr20	44422617	44422617	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgtcctgcagcccagcatCaacgaggagatccagactgt	10	7	11	13	1	1	2	1	0	0	2	3	4	3	2	3	1	4	3	3	1	1	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr20:44422617C>T	uc002xpk.2	+	3	302	c.234C>T	c.(232-234)ATC>ATT	p.I78I	WFDC3_uc002xpf.1_5'Flank|WFDC3_uc002xpj.1_5'Flank|WFDC3_uc002xph.1_5'Flank|WFDC3_uc010ghh.1_5'Flank	NM_052951	NP_443183	Q9H147	TDIF1_HUMAN	terminal deoxynucleotidyltransferase interacting	78						nucleus				ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.0122)				AGCCCAGCATCAACGAGGAGA	0.522													19	65					0	0	0	0	T	44422617	T	T	44422617	2	4	100	1	0	0	0	0	0	0	0	1	4703	816	29	2		2	DNTTIP1	20	44422617	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	38432064	44422617	18602903	138	19246											
NFATC2	4773	broad.mit.edu	37	chr20	50007976	50007976	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctgaaaactccttcctgAtaatttcattaactacaaaa	15	13	3	10	0	1	2	1	2	0	0	4	2	4	2	3	0	3	0	3	0	7	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr20:50007976A>G	uc002xwd.2	-	10	2955	c.2735T>C	c.(2734-2736)ATC>ACC	p.I912T	NFATC2_uc002xwc.2_3'UTR|NFATC2_uc010zyv.1_3'UTR|NFATC2_uc010zyw.1_Missense_Mutation_p.I693T|NFATC2_uc010zyx.1_3'UTR|NFATC2_uc010zyy.1_3'UTR|NFATC2_uc010zyz.1_Missense_Mutation_p.I693T|NFATC2_uc002xwe.2_Missense_Mutation_p.I892T	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	912	Nuclear export signal.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					CTCCTTCCTGATAATTTCATT	0.483													25	63					0	0	0	0	G	50007976	G	G	50007976	3	3	100	1	0	0	0	0	1	0	0	0	10416	333	12	5	46	5	NFATC2	20	50007976	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	5585359	50007976	13017544	139	19247											
SRMS	6725	broad.mit.edu	37	chr20	62178520	62178520	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggtgatgggcacgagcccGgcgctgggctggcccgaaag	6	5	19	11	4	0	1	0	1	0	0	0	3	0	1	2	5	1	3	2	5	1	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr20:62178520G>A	uc002yfi.1	-	1	338	c.297C>T	c.(295-297)GCC>GCT	p.A99A		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	99	SH3.						ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GCACGAGCCCGGCGCTGGGCT	0.697													25	48					0	0	0	0	A	62178520	A	A	62178520	2	1	100	1	0	0	0	0	0	0	0	1	15218	1103	39	1		1	SRMS	20	62178520	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	12170544	62178520	847000	140	19248											
GRIK1	2897	broad.mit.edu	37	chr21	31311810	31311810	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgggcgaggagtgtgccGtgctccatcttcctagcttc	4	11	14	12	2	1	0	0	0	1	0	4	2	3	1	3	3	3	3	3	3	1	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr21:31311810G>A	uc002yno.1	-	1	473	c.9C>T	c.(7-9)CAC>CAT	p.H3H	GRIK1_uc002ynn.2_Silent_p.H3H|GRIK1_uc011acs.1_Silent_p.H3H|GRIK1_uc011act.1_Silent_p.H3H|GRIK1_uc010glq.1_Silent_p.H3H|GRIK1_uc002ynr.2_Silent_p.H3H	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	3					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GGAGTGTGCCGTGCTCCATCT	0.622													4	10					0	0	0	0	A	31311810	A	A	31311810	2	1	100	1	0	0	0	0	0	0	0	1	6812	1136	40	1		1	GRIK1	21	31311810	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		31311810	16818085	141	19249											
COL6A1	1291	broad.mit.edu	37	chr21	47404294	47404294	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggcggccgcgacgcactCaaaagcagcgtggacgcggt	8	4	15	14	7	1	0	1	0	0	0	1	2	1	1	2	4	2	2	2	4	2	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr21:47404294C>G	uc002zhu.1	+	3	441	c.339C>G	c.(337-339)CTC>CTG	p.L113L		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	113	VWFA 1.|N-terminal globular domain.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GCGACGCACTCAAAAGCAGCG	0.632													7	20					0	0	0	0	G	47404294	G	G	47404294	2	3	100	1	0	0	0	0	0	0	0	1	3714	813	29	2		2	COL6A1	21	47404294	Silent	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	16092484	47404294	725601	142	19250											
MED15	51586	broad.mit.edu	37	chr22	20940876	20940876	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgccaaccccttcctccagtCggtgcaccgctgcatgacct	6	8	8	19	3	0	1	0	1	0	0	3	1	2	1	7	1	3	3	7	1	1	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:20940876C>T	uc002zsp.2	+	18	2332	c.2252C>T	c.(2251-2253)TCG>TTG	p.S751L	MED15_uc002zsq.2_Missense_Mutation_p.S711L|MED15_uc010gso.2_Missense_Mutation_p.S694L|MED15_uc002zsr.2_Missense_Mutation_p.S685L|MED15_uc011ahs.1_Missense_Mutation_p.S685L|MED15_uc002zss.2_Missense_Mutation_p.S630L|MED15_uc011ahu.1_Missense_Mutation_p.S461L|MED15_uc002zst.2_Missense_Mutation_p.S367L|MED15_uc002zsu.2_Missense_Mutation_p.S356L	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	751					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			TTCCTCCAGTCGGTGCACCGC	0.677													27	65					0	0	0	0	T	20940876	T	T	20940876	3	4	100	1	0	0	0	0	1	0	0	0	9486	893	31	1	2322	1	MED15	22	20940876	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08		20940876	30363690	143	19251											
CRYBB3	1417	broad.mit.edu	37	chr22	25601219	25601219	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaagctgcatctgtttgaGaacccagctttcagtggccg	9	10	10	12	1	2	1	1	1	1	1	2	2	2	1	2	1	4	4	2	1	2	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:25601219G>A	uc003abo.1	+	5	432	c.360G>A	c.(358-360)GAG>GAA	p.E120E		NM_004076	NP_004067	P26998	CRBB3_HUMAN	crystallin, beta B3	120	Beta/gamma crystallin 'Greek key' 3.				visual perception		protein binding|structural constituent of eye lens				0						ATCTGTTTGAGAACCCAGCTT	0.567													14	49					0	0	0	0	A	25601219	A	A	25601219	2	1	100	1	0	0	0	0	0	0	0	1	3927	933	33	2		2	CRYBB3	22	25601219	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	4660343	25601219	25703347	144	19252											
PLA2G6	8398	broad.mit.edu	37	chr22	38508233	38508233	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgctcatagatgtagacctCggtctcccagagggcgttga	8	10	13	10	2	2	4	1	1	1	3	4	4	2	4	2	2	1	3	2	2	2	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:38508233C>T	uc003auy.1	-	17	2492	c.2356G>A	c.(2356-2358)GAG>AAG	p.E786K	PLA2G6_uc003auz.1_Missense_Mutation_p.E732K|PLA2G6_uc003ava.1_Missense_Mutation_p.E786K|PLA2G6_uc003avb.2_Missense_Mutation_p.E732K|BAIAP2L2_uc003auw.2_5'Flank|PLA2G6_uc003aux.1_3'UTR	NM_003560	NP_003551	O60733	PA2G6_HUMAN	phospholipase A2, group VI isoform a	786					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				ovary(1)	1	Melanoma(58;0.045)				Quinacrine(DB01103)	ATGTAGACCTCGGTCTCCCAG	0.622													4	14					0	0	0	0	T	38508233	T	T	38508233	3	4	100	1	0	0	0	0	1	0	0	0	12063	893	31	1	68	1	PLA2G6	22	38508233	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	12907014	38508233	12796333	145	19253											
PLXNB2	23654	broad.mit.edu	37	chr22	50716549	50716549	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacccatgggggcccaccttGactgagagcagccgcgtcag	8	5	13	15	2	1	2	1	2	0	1	1	3	1	2	4	2	2	1	4	2	0	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:50716549G>A	uc003bkv.3	-	31	4990	c.4884C>T	c.(4882-4884)GTC>GTT	p.V1628V	PLXNB2_uc003bkt.1_Silent_p.V420V|PLXNB2_uc003bku.1_Silent_p.V613V	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1628	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGCCCACCTTGACTGAGAGCA	0.687													7	25					0	0	0	0	A	50716549	A	A	50716549	2	1	100	1	0	0	0	0	0	0	0	1	12179	1277	45	2		2	PLXNB2	22	50716549	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	12208316	50716549	588017	146	19254											
CPT1B	1375	broad.mit.edu	37	chr22	51010715	51010715	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccattcttgaaggaaatgaGagtgaaggatttgtcaaacc	14	10	11	6	0	2	3	1	3	1	1	2	6	2	5	2	2	1	0	2	2	4	3			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chr22:51010715G>C	uc003bmk.3	-	11	1537	c.1375C>G	c.(1375-1377)CTC>GTC	p.L459V	CPT1B_uc003bml.2_Missense_Mutation_p.L459V|CPT1B_uc003bmm.2_Missense_Mutation_p.L459V|CPT1B_uc003bmo.2_Missense_Mutation_p.L459V|CPT1B_uc011asa.1_Missense_Mutation_p.L425V|CPT1B_uc003bmn.2_Missense_Mutation_p.L459V|CPT1B_uc011asb.1_Missense_Mutation_p.L378V|CHKB-CPT1B_uc003bmp.2_Missense_Mutation_p.L256V|uc003bmr.1_RNA	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	459	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		AAGGAAATGAGAGTGAAGGAT	0.478													8	39					0	0	0	0	C	51010715	C	C	51010715	3	2	100	1	0	0	0	0	1	0	0	0	3847	942	33	2	975	2	CPT1B	22	51010715	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	294166	51010715	293851	147	19255											
DDX53	168400	broad.mit.edu	37	chrX	23019111	23019111	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagagttggctcttcacgtgGaagctgaatgttcaaagtat	11	12	12	6	1	3	2	2	1	1	1	3	4	3	3	0	2	1	5	0	2	4	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:23019111G>T	uc004daj.2	+	1	1025	c.937G>T	c.(937-939)GAA>TAA	p.E313*		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	313	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						TCTTCACGTGGAAGCTGAATG	0.398													24	49					5.24475e-26	7.47456e-26	1	0	T	23019111	T	T	23019111	4	4	100	1	0	0	0	0	0	1	0	0	4388	1175	41	2	939	2	DDX53	23	23019111	Nonsense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08		23019111	132251449	148	19256											
CXorf22	170063	broad.mit.edu	37	chrX	35989886	35989886	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaagagtctgtgagaagAaaggcacgtgcaatgtttta	14	9	14	4	1	1	3	0	1	1	3	1	6	1	4	0	2	1	3	0	2	5	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:35989886A>C	uc004ddj.2	+	12	2213	c.2154A>C	c.(2152-2154)AGA>AGC	p.R718S	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	718										large_intestine(1)|lung(1)|ovary(1)	3						CTGTGAGAAGAAAGGCACGTG	0.363													16	20					0	0	0	0	C	35989886	C	C	35989886	3	2	100	1	0	0	0	0	1	0	0	0	4119	243	9	5	2200	5	CXorf22	23	35989886	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	12970775	35989886	119280674	149	19257											
RIBC1	158787	broad.mit.edu	37	chrX	53455530	53455530	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggtacaacttggaaaggCaacagcaggagcaacagcaa	17	4	11	9	0	1	0	1	0	0	0	1	2	1	2	0	4	7	5	0	4	6	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:53455530C>T	uc004dsk.2	+	5	652	c.499C>T	c.(499-501)CAA>TAA	p.Q167*	RIBC1_uc004dsj.1_Nonsense_Mutation_p.Q167*|RIBC1_uc011mog.1_Intron	NM_001031745	NP_001026915	Q8N443	RIBC1_HUMAN	RIB43A domain with coiled-coils 1 isoform 1	167											0						CTTGGAAAGGCAACAGCAGGA	0.562													15	9					0	0	0	0	T	53455530	T	T	53455530	4	4	100	1	0	0	0	0	0	1	0	0	13417	711	25	4	509	4	RIBC1	23	53455530	Nonsense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	17465644	53455530	101815030	150	19258											
OGT	8473	broad.mit.edu	37	chrX	70787355	70787355	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttccctattttagattctGaagcgtgttcccaatagtgt	8	18	7	8	1	1	2	0	1	1	1	3	2	3	2	2	0	1	1	2	0	5	8			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:70787355G>A	uc004eaa.1	+	20	2812	c.2595G>A	c.(2593-2595)CTG>CTA	p.L865L	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.L855L|OGT_uc004eac.2_Silent_p.L726L|OGT_uc004ead.2_Silent_p.L484L	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	865					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					TTTAGATTCTGAAGCGTGTTC	0.398													18	40					0	0	0	0	A	70787355	A	A	70787355	2	1	100	1	0	0	0	0	0	0	0	1	10901	1277	45	2		2	OGT	23	70787355	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	17331825	70787355	84483205	151	19259											
NAP1L2	4674	broad.mit.edu	37	chrX	72433920	72433920	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catttcagcaaactttctttCaatgtcatgaaattccctca	12	15	3	11	0	5	1	4	1	1	0	6	1	6	1	1	0	2	1	1	0	3	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:72433920C>T	uc004ebi.2	-	1	765	c.409G>A	c.(409-411)GAA>AAA	p.E137K	NAP1L2_uc011mqj.1_5'UTR	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	137					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					AACTTTCTTTCAATGTCATGA	0.373													29	99					0	0	0	0	T	72433920	T	T	72433920	3	4	100	1	0	0	0	0	1	0	0	0	10210	835	29	2	977	2	NAP1L2	23	72433920	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	1646565	72433920	82836640	152	19260											
KIAA2022	340533	broad.mit.edu	37	chrX	73960449	73960449	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggacaagatataggaaggctCctgaaattcccgttggtcat	12	10	11	8	1	1	2	1	1	0	1	3	4	3	4	2	4	0	2	2	4	5	4			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:73960449C>A	uc004eby.2	-	3	4560	c.3943G>T	c.(3943-3945)GAG>TAG	p.E1315*		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1315					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TAGGAAGGCTCCTGAAATTCC	0.532													37	110					6.99958e-10	9.41186e-10	1	0	A	73960449	A	A	73960449	4	1	100	1	0	0	0	0	0	1	0	0	8308	864	30	2	615	2	KIAA2022	23	73960449	Nonsense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	1526529	73960449	81310111	153	19261											
TBX22	50945	broad.mit.edu	37	chrX	79281179	79281179	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattcctagattctatgttcAcccggactcaccctgctcgg	7	12	7	15	2	3	1	2	0	1	1	5	2	4	2	3	2	1	2	3	2	2	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:79281179A>T	uc010nmg.1	+	5	670	c.536A>T	c.(535-537)CAC>CTC	p.H179L	TBX22_uc004edi.1_Missense_Mutation_p.H59L|TBX22_uc004edj.1_Missense_Mutation_p.H179L	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	179	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						TTCTATGTTCACCCGGACTCA	0.488													25	71					0	0	0	0	T	79281179	T	T	79281179	3	4	100	1	0	0	0	0	1	0	0	0	15724	159	6	5	550	5	TBX22	23	79281179	Missense_Mutation	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	5320730	79281179	75989381	154	19262											
BRWD3	254065	broad.mit.edu	37	chrX	79946660	79946660	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatccactggaacagcaaaaGggctggcaaaatctacaaaa	18	5	9	9	0	1	0	0	0	1	0	2	2	2	1	1	3	3	3	1	3	8	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:79946660G>C	uc004edt.2	-	31	3757	c.3494C>G	c.(3493-3495)CCT>CGT	p.P1165R	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.P761R|BRWD3_uc004edp.2_Missense_Mutation_p.P994R|BRWD3_uc004edq.2_Missense_Mutation_p.P761R|BRWD3_uc010nmj.1_Missense_Mutation_p.P761R|BRWD3_uc004edr.2_Missense_Mutation_p.P835R|BRWD3_uc004eds.2_Missense_Mutation_p.P761R|BRWD3_uc004edu.2_Missense_Mutation_p.P835R|BRWD3_uc004edv.2_Missense_Mutation_p.P761R|BRWD3_uc004edw.2_Missense_Mutation_p.P761R|BRWD3_uc004edx.2_Missense_Mutation_p.P761R|BRWD3_uc004edy.2_Missense_Mutation_p.P761R|BRWD3_uc004edz.2_Missense_Mutation_p.P835R|BRWD3_uc004eea.2_Missense_Mutation_p.P835R|BRWD3_uc004eeb.2_Missense_Mutation_p.P761R	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1165	Bromo 1.									ovary(4)	4						AACAGCAAAAGGGCTGGCAAA	0.373													14	30					0	0	0	0	C	79946660	C	C	79946660	3	2	100	1	0	0	0	0	1	0	0	0	1531	1000	35	4	1958	4	BRWD3	23	79946660	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	665481	79946660	75323900	155	19263											
SLC25A43	203427	broad.mit.edu	37	chrX	118586008	118586008	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccacacagtggaggagtaGatgtccatttctcaggagca	11	9	11	10	0	1	1	1	0	1	1	4	4	3	4	2	3	1	2	2	3	1	2			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:118586008G>C	uc004erd.2	+	4	1071	c.727G>C	c.(727-729)GAT>CAT	p.D243H	SLC25A43_uc004erc.1_RNA|SLC25A43_uc011mtt.1_Missense_Mutation_p.R185T	NM_145305	NP_660348	Q8WUT9	S2543_HUMAN	mitochondrial solute carrier protein	243	Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			skin(1)	1						TGGAGGAGTAGATGTCCATTT	0.512													32	112					0	0	0	0	C	118586008	C	C	118586008	3	2	100	1	0	0	0	0	1	0	0	0	14572	942	33	2	741	2	SLC25A43	23	118586008	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	38639348	118586008	36684552	156	19264											
F9	2158	broad.mit.edu	37	chrX	138612944	138612944	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcagcgcgtgaacatgatCatggcagaatcaccaggcct	12	7	11	11	2	2	3	2	2	0	1	2	3	2	3	2	2	3	2	2	2	2	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:138612944C>G	uc004fas.1	+	1	50	c.21C>G	c.(19-21)ATC>ATG	p.I7M	F9_uc004fat.1_Missense_Mutation_p.I7M	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	7			I -> F.		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGAACATGATCATGGCAGAAT	0.413													13	144					0	0	0	0	G	138612944	G	G	138612944	3	3	100	1	0	0	0	0	1	0	0	0	5379	816	29	2	23	2	F9	23	138612944	Missense_Mutation	SNP	C	TCGA-CQ-6218-01A-11D-1912-08	20026936	138612944	16657616	157	19265											
AFF2	2334	broad.mit.edu	37	chrX	148037550	148037550	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagcactcccaaagaaaaaGaaagtgtggagcttcatgac	16	6	10	9	0	1	3	1	1	0	2	2	4	2	4	1	1	2	3	1	1	4	1			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:148037550G>C	uc004fcp.2	+	11	2454	c.1975G>C	c.(1975-1977)GAA>CAA	p.E659Q	AFF2_uc004fcq.2_Missense_Mutation_p.E649Q|AFF2_uc004fcr.2_Missense_Mutation_p.E620Q|AFF2_uc011mxb.1_Missense_Mutation_p.E624Q|AFF2_uc004fcs.2_Missense_Mutation_p.E626Q|AFF2_uc011mxc.1_Missense_Mutation_p.E300Q	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	659					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CAAAGAAAAAGAAAGTGTGGA	0.483													39	159					0	0	0	0	C	148037550	C	C	148037550	3	2	100	1	0	0	0	0	1	0	0	0	357	943	33	2	2072	2	AFF2	23	148037550	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	9424606	148037550	7233010	158	19266											
MAGEA11	4110	broad.mit.edu	37	chrX	148797305	148797305	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctggaggacaggagtcccagGagaacccagaggatcactgg	12	4	15	10	0	1	2	1	0	0	2	2	7	2	6	2	6	1	0	2	6	1	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:148797305G>T	uc004fdq.2	+	4	336	c.234G>T	c.(232-234)AGG>AGT	p.R78S	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.R49S	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	78						cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GGAGTCCCAGGAGAACCCAGA	0.502													31	124					1.99505e-19	2.8096e-19	1	0	T	148797305	T	T	148797305	3	4	100	1	0	0	0	0	1	0	0	0	9216	1165	41	2	257	2	MAGEA11	23	148797305	Missense_Mutation	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	759755	148797305	6473255	159	19267											
PNMA5	114824	broad.mit.edu	37	chrX	152159807	152159807	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtcatacttcggccctcAtctttcaggaagtagttcag	8	14	8	11	1	6	0	4	0	2	0	7	1	6	1	1	2	1	2	1	2	3	5			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:152159807A>G	uc010ntw.2	-	3	675	c.336T>C	c.(334-336)GAT>GAC	p.D112D	PNMA5_uc004fha.3_Silent_p.D112D|PNMA5_uc010ntx.2_Silent_p.D112D|PNMA5_uc004fgy.3_Silent_p.D112D	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	112					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ttcggccctcatctttcagga	0.09													46	241					0	0	0	0	G	152159807	G	G	152159807	2	3	100	1	0	0	0	0	0	0	0	1	12211	214	8	5		5	PNMA5	23	152159807	Silent	SNP	A	TCGA-CQ-6218-01A-11D-1912-08	3362502	152159807	3110753	160	19268											
LAGE3	8270	broad.mit.edu	37	chrX	153706741	153706741	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagggggtcgggaaaggcacGctgagggtgctgggggtcat	8	6	21	6	2	1	1	1	1	0	0	2	2	1	2	0	7	1	3	0	7	2	0			TCGA-CQ-6218-01A-11D-1912-08	TCGA-CQ-6218-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	d3717097-7cdb-446f-a020-78c770362656	8e02ba07-6e8c-4016-af03-7601c57fbc9a	g.chrX:153706741G>A	uc004fln.1	-	2	540	c.198C>T	c.(196-198)AGC>AGT	p.S66S		NM_006014	NP_006005	Q14657	LAGE3_HUMAN	L antigen family, member 3	66							protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGAAAGGCACGCTGAGGGTGC	0.602													24	110					0	0	0	0	A	153706741	A	A	153706741	2	1	100	1	0	0	0	0	0	0	0	1	8641	1078	38	1		1	LAGE3	23	153706741	Silent	SNP	G	TCGA-CQ-6218-01A-11D-1912-08	1546934	153706741	1563819	161	19269											
PABPC4	8761	broad.mit.edu	37	chr1	40036937	40036937	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgaggagcatgccattcaTcttctcgatggccttgtcgg	7	13	11	10	2	3	1	1	1	2	0	5	3	3	2	2	3	2	1	2	3	0	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr1:40036937T>C	uc010oiv.1	-	3	1370	c.472A>G	c.(472-474)ATG>GTG	p.M158V	PABPC4_uc001cdl.2_Missense_Mutation_p.M158V|PABPC4_uc001cdm.2_Missense_Mutation_p.M158V	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	158	RRM 2.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			ATGCCATTCATCTTCTCGATG	0.552													21	160					0	0	0	0	C	40036937	C	C	40036937	3	2	101	1	0	0	0	0	1	0	0	0	11420	1435	50	5	1562	5	PABPC4	1	40036937	Missense_Mutation	SNP	T	TCGA-CQ-6219-01A-11D-1912-08		40036937	209213684	1	19270											
MYCL1	4610	broad.mit.edu	37	chr1	40366859	40366859	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgatggaggcgtagttcctgCcccagcctttcgagtggccc	5	10	13	13	2	0	1	0	1	0	0	2	3	1	2	5	3	2	2	5	3	1	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr1:40366859C>A	uc001cer.1	-	2	465	c.248G>T	c.(247-249)GGC>GTC	p.G83V	MYCL1_uc001ces.1_Missense_Mutation_p.G83V|MYCL1_uc001cet.1_Missense_Mutation_p.G83V	NM_001033082	NP_001028254	P12524	MYCL1_HUMAN	l-myc-1 proto-oncogene isoform 1	83						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|liver(1)	2	all_cancers(7;1.73e-14)|all_lung(5;2.77e-17)|all_epithelial(6;6.81e-17)|Lung SC(1;2.85e-13)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.51e-19)|Epithelial(16;3.36e-18)|all cancers(16;8.43e-17)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GTAGTTCCTGCCCCAGCCTTT	0.711			A		small cell lung 								5	28					0.00116845	0.00143034	1	0	A	40366859	A	A	40366859	3	1	101	1	0	0	0	0	1	0	0	0	10073	739	26	4	979	4	MYCL1	1	40366859	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	329922	40366859	208883762	2	19271											
KANK4	163782	broad.mit.edu	37	chr1	62740512	62740512	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	accacgggagaccagttttgGaggggcggggctgcaggggg	7	5	21	8	2	0	1	0	0	0	1	0	3	0	2	2	8	1	3	2	8	0	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr1:62740512G>A	uc001dah.3	-	3	641	c.264C>T	c.(262-264)CTC>CTT	p.L88L	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	88										ovary(3)|skin(2)|lung(1)	6						ACCAGTTTTGGAGGGGCGGGG	0.602													6	153					0	0	0	0	A	62740512	A	A	62740512	2	1	101	1	0	0	0	0	0	0	0	1	8018	1161	41	2		2	KANK4	1	62740512	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	22373653	62740512	186510109	3	19272											
ZNF326	284695	broad.mit.edu	37	chr1	90459479	90459479	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggtgatttccatattgctCaggtcacatgctacctctgc	7	14	8	12	1	3	1	2	1	1	0	5	1	4	1	2	2	4	2	2	2	2	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr1:90459479C>T	uc001dnq.2	+						GEMIN8P4_uc001dno.2_RNA|ZNF326_uc001dnp.3_5'Flank|ZNF326_uc009wda.1_5'Flank|ZNF326_uc001dnr.2_5'Flank	NM_182976	NP_892021	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			ovary(1)	1		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		CCATATTGCTCAGGTCACATG	0.542													11	100					0	0	0	0	T	90459479	T	T	90459479	1	4	101	0	1	0	0	0	0	0	0	0	17913	841	29	2		2	ZNF326	1	90459479	5'Flank	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	27718967	90459479	158791142	4	19273											
HRNR	388697	broad.mit.edu	37	chr1	152191918	152191918	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgtcctgacctagagccGtgttttctgtagccggagga	7	11	13	10	2	1	2	0	1	1	1	2	5	2	4	4	2	2	2	4	2	2	4	rs146453724	byFrequency	TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr1:152191918G>A	uc001ezt.1	-	3	2263	c.2187C>T	c.(2185-2187)CAC>CAT	p.H729H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	729	7.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTAGAGCCGTGTTTTCTGT	0.537													20	248					0	0	0	0	A	152191918	A	A	152191918	2	1	101	1	0	0	0	0	0	0	0	1	7398	1136	40	1		1	HRNR	1	152191918	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	61732439	152191918	97058703	5	19274											
COPA	1314	broad.mit.edu	37	chr1	160276272	160276272	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgatctcattcttcagattCttgatcagaagctgcaataa	12	14	7	8	0	5	4	3	2	3	2	6	4	5	4	0	0	2	2	0	0	3	5			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr1:160276272C>T	uc009wti.2	-	15	1708	c.1314G>A	c.(1312-1314)AAG>AAA	p.K438K	COPA_uc001fvv.3_Silent_p.K438K|COPA_uc009wtj.1_Silent_p.K384K	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	438					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCTTCAGATTCTTGATCAGAA	0.413													7	59					0	0	0	0	T	160276272	T	T	160276272	2	4	101	1	0	0	0	0	0	0	0	1	3742	912	32	2		2	COPA	1	160276272	Silent	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	8084354	160276272	88974349	6	19275											
ARHGAP30	257106	broad.mit.edu	37	chr1	161017681	161017681	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caggcagctaaggggccgagGagaatgggcagagatcatgc	12	4	17	8	1	1	2	1	0	0	2	1	5	1	2	1	5	2	3	1	5	2	1			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr1:161017681G>A	uc001fxl.2	-	12	3476	c.3130C>T	c.(3130-3132)CCT>TCT	p.P1044S	USF1_uc001fxi.2_5'Flank|USF1_uc001fxj.2_5'Flank|ARHGAP30_uc001fxk.2_Missense_Mutation_p.P833S|ARHGAP30_uc001fxm.2_Missense_Mutation_p.P890S|ARHGAP30_uc009wtx.2_Missense_Mutation_p.P717S	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	1044					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			AGGGGCCGAGGAGAATGGGCA	0.592													12	62					0	0	0	0	A	161017681	A	A	161017681	3	1	101	1	0	0	0	0	1	0	0	0	879	1174	41	2	179	2	ARHGAP30	1	161017681	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	741409	161017681	88232940	7	19276											
NBAS	51594	broad.mit.edu	37	chr2	15374713	15374713	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attgcactctgcactatatcCttgggtgagatgtcaagagg	10	12	11	8	0	2	2	1	1	1	2	3	3	3	2	1	2	2	2	1	2	3	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr2:15374713C>T	uc002rcc.1	-	46	6128	c.6102G>A	c.(6100-6102)AAG>AAA	p.K2034K	NBAS_uc002rcb.1_5'UTR|NBAS_uc010exl.1_Silent_p.K1106K|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	2034										ovary(2)|liver(1)|skin(1)	4						GCACTATATCCTTGGGTGAGA	0.443													5	69					0	0	0	0	T	15374713	T	T	15374713	2	4	101	1	0	0	0	0	0	0	0	1	10239	680	24	4		4	NBAS	2	15374713	Silent	SNP	C	TCGA-CQ-6219-01A-11D-1912-08		15374713	227824660	8	19277											
NT5C1B	93034	broad.mit.edu	37	chr2	18736913	18736913	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagaaactaccacaatcctGctgggagctgaacttttgag	13	9	10	9	0	0	3	0	2	0	1	1	5	1	4	2	1	5	2	2	1	5	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr2:18736913G>A	uc010exr.2	-	9	1601	c.1497C>T	c.(1495-1497)AGC>AGT	p.S499S	NT5C1B_uc002rcy.2_3'UTR|RDH14_uc002rcx.3_Silent_p.S185S	NM_033253	NP_150278	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 2	Error:Variant_position_missing_in_Q96P26_after_alignment					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				CCACAATCCTGCTGGGAGCTG	0.408													6	68					0	0	0	0	A	18736913	A	A	18736913	2	1	101	1	0	0	0	0	0	0	0	1	10740	1310	46	4		4	NT5C1B	2	18736913	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	3362200	18736913	224462460	9	19278											
SLC30A3	7781	broad.mit.edu	37	chr2	27480185	27480186	+	Frame_Shift_Ins	INS	-	G	G																															tcccctagacccgtggctgtINSgggggggcccagcctggtgc																								rs148758588		TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr2:27480185_27480186insG	uc002rjk.2	-	5	799_800	c.613_614insC	c.(613-615)CACfs	p.H205fs	SLC30A3_uc002rjj.2_Frame_Shift_Ins_p.P50fs|SLC30A3_uc010ylh.1_Frame_Shift_Ins_p.H200fs	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	205	Cytoplasmic (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCGTGGCTGTGGGGGGGCCCA	0.658													---	---	---								G	27480186	G	G	27480185	7	5	101	1	0	1	1	0	0	0	0	0	14620	1696	59	0	568	0	SLC30A3	2	27480185	Frame_Shift_Ins	INS	-	TCGA-CQ-6219-01A-11D-1912-08	8743272	27480185	215719188	10	19279											
CTNNA2	1496	broad.mit.edu	37	chr2	80085227	80085227	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atggtacgggcggcaagggcTttgctctccgcggtgacacg	6	8	16	11	5	1	1	0	1	1	0	2	1	1	1	1	5	2	4	1	5	2	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr2:80085227T>G	uc010ysh.1	+	3	392	c.387T>G	c.(385-387)GCT>GCG	p.A129A	CTNNA2_uc010yse.1_Silent_p.A129A|CTNNA2_uc010ysf.1_Silent_p.A129A|CTNNA2_uc010ysg.1_Silent_p.A129A	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	129					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CGGCAAGGGCTTTGCTCTCCG	0.532													7	97					0	0	0	0	G	80085227	G	G	80085227	2	3	101	1	0	0	0	0	0	0	0	1	4030	1596	56	5		5	CTNNA2	2	80085227	Silent	SNP	T	TCGA-CQ-6219-01A-11D-1912-08	52605042	80085227	163114146	11	19280											
RIF1	55183	broad.mit.edu	37	chr2	152319685	152319685	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccccataccctacaagtcgGaggcaaacctttattacttt	11	11	5	14	1	0	0	0	0	0	0	1	1	0	1	4	2	4	1	4	2	6	6			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr2:152319685G>A	uc002txm.2	+	30	3781	c.3651G>A	c.(3649-3651)CGG>CGA	p.R1217R	RIF1_uc002txl.2_Silent_p.R1217R|RIF1_uc002txn.2_Silent_p.R1217R|RIF1_uc002txo.2_Silent_p.R1217R|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1217					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		CTACAAGTCGGAGGCAAACCT	0.388													11	64					0	0	0	0	A	152319685	A	A	152319685	2	1	101	1	0	0	0	0	0	0	0	1	13424	1161	41	2		2	RIF1	2	152319685	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	72234458	152319685	90879688	12	19281											
KCNJ3	3760	broad.mit.edu	37	chr2	155566303	155566303	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacagttcgagattgtcgtCatcctagaaggcattgtgga	11	11	12	7	2	1	2	1	0	0	2	4	5	2	3	1	2	1	2	1	2	3	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr2:155566303C>T	uc002tyv.1	+	2	1086	c.891C>T	c.(889-891)GTC>GTT	p.V297V	KCNJ3_uc010zce.1_Intron	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	297	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	AGATTGTCGTCATCCTAGAAG	0.413													4	55					0	0	0	0	T	155566303	T	T	155566303	2	4	101	1	0	0	0	0	0	0	0	1	8091	813	29	2		2	KCNJ3	2	155566303	Silent	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	3246618	155566303	87633070	13	19282											
ITGAV	3685	broad.mit.edu	37	chr2	187529348	187529348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactgcaggctgatttcatcGgggttgtccgaaacaatgaa	11	10	11	9	2	1	2	1	2	0	0	3	3	2	2	1	3	2	3	1	3	3	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr2:187529348G>A	uc002upq.2	+	20	2329	c.2053G>A	c.(2053-2055)GGG>AGG	p.G685R	ITGAV_uc010frs.2_Missense_Mutation_p.G649R|ITGAV_uc010zfv.1_Missense_Mutation_p.G639R	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	685	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TGATTTCATCGGGGTTGTCCG	0.433													14	137					0	0	0	0	A	187529348	A	A	187529348	3	1	101	1	0	0	0	0	1	0	0	0	7927	1116	39	1	2182	1	ITGAV	2	187529348	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	31963045	187529348	55670025	14	19283											
PLCL1	5334	broad.mit.edu	37	chr2	198948736	198948736	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatttctgccataaaagaGatcagactggggaaaaacac	17	8	9	7	0	2	2	1	0	1	2	2	5	2	3	1	2	2	0	1	2	5	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr2:198948736G>T	uc010fsp.2	+	2	786	c.495G>T	c.(493-495)GAG>GAT	p.E165D	PLCL1_uc002uuv.3_Missense_Mutation_p.E86D	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	165	PH.|Interaction with PPP1C.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CCATAAAAGAGATCAGACTGG	0.453													23	67					2.70639e-06	3.46223e-06	1	0	T	198948736	T	T	198948736	3	4	101	1	0	0	0	0	1	0	0	0	12094	933	33	2	501	2	PLCL1	2	198948736	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	11419388	198948736	44250637	15	19284											
PAX3	5077	broad.mit.edu	37	chr2	223066811	223066811	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgactgcagctggccgacacCgtggtggtaggttccagacc	7	8	14	12	2	0	2	0	1	0	1	1	3	1	2	4	4	2	4	4	4	1	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr2:223066811C>T	uc010fwo.2	-	8	1638	c.1272G>A	c.(1270-1272)ACG>ACA	p.T424T	PAX3_uc002vmt.1_Silent_p.T424T|PAX3_uc002vmy.1_Silent_p.T423T|PAX3_uc002vmv.1_Silent_p.T424T|PAX3_uc002vmw.1_Intron|PAX3_uc002vmx.1_Intron	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	424					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGCCGACACCGTGGTGGTAG	0.577			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						6	40					0	0	0	0	T	223066811	T	T	223066811	2	4	101	1	0	0	0	0	0	0	0	1	11534	639	23	1		1	PAX3	2	223066811	Silent	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	24118075	223066811	20132562	16	19285											
TRIP12	9320	broad.mit.edu	37	chr2	230650483	230650483	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaagctcacctcattttcaTactggatttctaacatggcc	10	13	5	13	0	4	0	3	0	1	0	4	1	4	1	3	2	3	1	3	2	3	5			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr2:230650483T>A	uc002vpw.1	-	33	4968	c.4859A>T	c.(4858-4860)TAT>TTT	p.Y1620F	TRIP12_uc002vpx.1_Missense_Mutation_p.Y1668F|TRIP12_uc002vpy.1_Missense_Mutation_p.Y1350F	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1620					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CTCATTTTCATACTGGATTTC	0.438													7	89					0	0	0	0	A	230650483	A	A	230650483	3	1	101	1	0	0	0	0	1	0	0	0	16623	1406	49	5	1155	5	TRIP12	2	230650483	Missense_Mutation	SNP	T	TCGA-CQ-6219-01A-11D-1912-08	7583672	230650483	12548890	17	19286											
ABHD10	55347	broad.mit.edu	37	chr3	111710339	111710340	+	Frame_Shift_Ins	INS	-	A	A																															gctgaacatcactgcttgttINSacatagcccaattcctgtga																										TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr3:111710339_111710340insA	uc003dyk.3	+	5	773_774	c.692_693insA	c.(691-693)TTAfs	p.L231fs	ABHD10_uc011bhq.1_Frame_Shift_Ins_p.L74fs	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	231						mitochondrion	serine-type peptidase activity				0						CACTGCTTGTTACATAGCCCAA	0.431													---	---	---								A	111710340	A	A	111710339	7	5	101	1	0	1	1	0	0	0	0	0	74	1764	61	0	710	0	ABHD10	3	111710339	Frame_Shift_Ins	INS	-	TCGA-CQ-6219-01A-11D-1912-08		111710339	86312091	18	19287											
POLQ	10721	broad.mit.edu	37	chr3	121206259	121206259	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaccgccactccttaatgAatgtttggaaaagattttgg	11	13	9	8	1	0	2	0	1	0	1	1	3	1	3	3	2	1	2	3	2	4	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr3:121206259A>T	uc003eee.3	-	16	5648	c.5519T>A	c.(5518-5520)TTC>TAC	p.F1840Y	POLQ_uc003eed.2_Missense_Mutation_p.F1012Y	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1840					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CTCCTTAATGAATGTTTGGAA	0.393								DNA_polymerases_(catalytic_subunits)					9	82					0	0	0	0	T	121206259	T	T	121206259	3	4	101	1	0	0	0	0	1	0	0	0	12263	246	9	5	2313	5	POLQ	3	121206259	Missense_Mutation	SNP	A	TCGA-CQ-6219-01A-11D-1912-08	9495920	121206259	76816171	19	19288											
DHX36	170506	broad.mit.edu	37	chr3	154027540	154027540	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaaatgaactgagtaacttGagtggttttgccacaaccag	14	10	9	8	0	0	3	0	3	0	0	0	3	0	3	2	1	4	2	2	1	5	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr3:154027540G>A	uc003ezy.3	-	5	796	c.715C>T	c.(715-717)CAA>TAA	p.Q239*	DHX36_uc010hvq.2_Nonsense_Mutation_p.Q239*|DHX36_uc003ezz.3_Nonsense_Mutation_p.Q239*	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	239	Helicase ATP-binding.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGAGTAACTTGAGTGGTTTTG	0.338													5	29					0	0	0	0	A	154027540	A	A	154027540	4	1	101	1	0	0	0	0	0	1	0	0	4531	1299	45	2	2395	2	DHX36	3	154027540	Nonsense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	32821281	154027540	43994890	20	19289											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			7	53					0	0	0	0	A	178936091	A	A	178936091	3	1	101	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	24908551	178936091	19086339	21	19290											
PSMD2	5708	broad.mit.edu	37	chr3	184025484	184025484	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaacaacctcttcatggtGcgcttggcacaggtaaagaa	13	8	9	11	1	2	1	1	0	1	1	2	1	2	1	2	3	3	3	2	3	5	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr3:184025484G>A	uc003fnn.1	+	18	2319	c.2286G>A	c.(2284-2286)GTG>GTA	p.V762V	PSMD2_uc011brj.1_Silent_p.V603V|PSMD2_uc011brk.1_Silent_p.V632V	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	762					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	TCTTCATGGTGCGCTTGGCAC	0.507													7	46					0	0	0	0	A	184025484	A	A	184025484	2	1	101	1	0	0	0	0	0	0	0	1	12760	1306	46	4		4	PSMD2	3	184025484	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	5089393	184025484	13996946	22	19291											
LGI2	55203	broad.mit.edu	37	chr4	25005706	25005706	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacaaagaacgtctcgtcGtcgatctgaaacagctcgat	13	9	9	10	5	2	3	0	2	2	1	6	5	2	3	0	0	3	1	0	0	3	0			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr4:25005706G>A	uc003grf.2	-	8	1104	c.1005C>T	c.(1003-1005)GAC>GAT	p.D335D		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	335	EAR 3.					extracellular region					0		Breast(46;0.173)				ACGTCTCGTCGTCGATCTGAA	0.443													14	81					0	0	0	0	A	25005706	A	A	25005706	2	1	101	1	0	0	0	0	0	0	0	1	8793	1136	40	1		1	LGI2	4	25005706	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08		25005706	166148570	23	19292											
WDFY3	23001	broad.mit.edu	37	chr4	85701359	85701359	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatataacccttccacatCagaggccatggccaccaggc	11	7	8	15	0	1	1	1	0	0	1	2	1	2	1	5	3	2	1	5	3	2	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr4:85701359C>A	uc003hpd.2	-	26	4675	c.4267G>T	c.(4267-4269)GAT>TAT	p.D1423Y		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1423						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CCTTCCACATCAGAGGCCATG	0.507													23	123					3.62473e-10	4.6792e-10	1	0	A	85701359	A	A	85701359	3	1	101	1	0	0	0	0	1	0	0	0	17338	826	29	2	6485	2	WDFY3	4	85701359	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	60695653	85701359	105452917	24	19293											
CENPE	1062	broad.mit.edu	37	chr4	104082361	104082361	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcctccaactggctttgataTaactgaatatcattttccat	11	15	5	10	0	1	2	1	2	0	0	3	2	3	2	3	1	2	1	3	1	5	6			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr4:104082361T>A	uc003hxb.1	-	20	2103	c.2013A>T	c.(2011-2013)TTA>TTT	p.L671F	CENPE_uc003hxc.1_Missense_Mutation_p.L646F	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	671	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GGCTTTGATATAACTGAATAT	0.323													5	32					0	0	0	0	A	104082361	A	A	104082361	3	1	101	1	0	0	0	0	1	0	0	0	3245	1403	49	5	6212	5	CENPE	4	104082361	Missense_Mutation	SNP	T	TCGA-CQ-6219-01A-11D-1912-08	18381002	104082361	87071915	25	19294											
CFI	3426	broad.mit.edu	37	chr4	110670474	110670474	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccacctgccatgggaggtCtccctgtaaaagacatttgt	9	11	10	11	0	1	1	0	0	1	1	2	2	1	2	4	2	2	1	4	2	2	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr4:110670474C>A	uc003hzr.3	-	10	1256	c.1048G>T	c.(1048-1050)GAC>TAC	p.D350Y	CFI_uc003hzq.2_Missense_Mutation_p.D147Y|CFI_uc011cft.1_Missense_Mutation_p.D358Y|CFI_uc003hzs.3_Missense_Mutation_p.D343Y	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	350	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		CATGGGAGGTCTCCCTGTAAA	0.458													16	160					6.72482e-11	8.76078e-11	1	0	A	110670474	A	A	110670474	3	1	101	1	0	0	0	0	1	0	0	0	3304	913	32	2	719	2	CFI	4	110670474	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	6588113	110670474	80483802	26	19295											
RASA1	5921	broad.mit.edu	37	chr5	86658371	86658371	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttttttaaaattcaggatCaagaacaagtactcaatgac	16	13	6	6	0	3	2	3	1	0	1	3	3	3	3	0	1	2	2	0	1	7	5			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr5:86658371C>G	uc003kiw.2	+	10	1454	c.1336C>G	c.(1336-1338)CAA>GAA	p.Q446E	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.Q269E|RASA1_uc011ctv.1_Missense_Mutation_p.Q279E|RASA1_uc011ctw.1_Missense_Mutation_p.Q280E|RASA1_uc010jaw.2_Missense_Mutation_p.Q268E	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	446					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		AATTCAGGATCAAGAACAAGT	0.294													6	61					0	0	0	0	G	86658371	G	G	86658371	3	3	101	1	0	0	0	0	1	0	0	0	13125	827	29	2	1386	2	RASA1	5	86658371	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08		86658371	94256889	27	19296											
PAM	5066	broad.mit.edu	37	chr5	102296933	102296933	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagaagaagtgttagaccagGgtatgtatgcttatttctat	13	14	10	4	0	1	3	0	0	1	3	1	3	1	3	1	1	1	4	1	1	8	6			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr5:102296933G>C	uc003knw.2	+	13	1535	c.1162G>C	c.(1162-1164)GGT>CGT	p.G388R	PAM_uc003kns.2_Missense_Mutation_p.D388H|PAM_uc003knt.2_Missense_Mutation_p.G388R|PAM_uc003knu.2_Missense_Mutation_p.G388R|PAM_uc003knv.2_Missense_Mutation_p.G388R|PAM_uc011cuz.1_Missense_Mutation_p.G291R|PAM_uc003knx.1_Missense_Mutation_p.A80P	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	388	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	GTTAGACCAGGGTATGTATGC	0.333													4	59					0	0	0	0	C	102296933	C	C	102296933	3	2	101	1	0	0	0	0	1	0	0	0	11466	1246	43	4	1212	4	PAM	5	102296933	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	15638562	102296933	78618327	28	19297											
RBM27	54439	broad.mit.edu	37	chr5	145651234	145651234	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagacttgcttcagcatttCtcagtaagtttttaaaatag	13	15	7	6	0	2	1	2	0	1	1	3	2	2	1	0	0	2	4	0	0	5	8			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr5:145651234C>T	uc003lnz.3	+	19	3151	c.2985C>T	c.(2983-2985)TTC>TTT	p.F995F		NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	995					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAGCATTTCTCAGTAAGTT	0.383													5	32					0	0	0	0	T	145651234	T	T	145651234	2	4	101	1	0	0	0	0	0	0	0	1	13192	912	32	2		2	RBM27	5	145651234	Silent	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	43354301	145651234	35264026	29	19298											
VPS52	6293	broad.mit.edu	37	chr6	33237326	33237326	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgctatattctcactctCttgaatatctgatccacaaa	13	14	4	10	0	3	3	1	2	3	1	6	3	4	3	1	0	1	1	1	0	5	5			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr6:33237326C>G	uc003odm.1	-	5	523	c.313G>C	c.(313-315)GAG>CAG	p.E105Q	VPS52_uc003odn.1_5'UTR|VPS52_uc003odo.1_Missense_Mutation_p.E30Q|VPS52_uc011dqy.1_5'UTR|VPS52_uc011dqz.1_5'UTR|RPS18_uc003odp.1_5'Flank|RPS18_uc010jum.1_5'Flank	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	105					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						TTCTCACTCTCTTGAATATCT	0.428													6	88					0	0	0	0	G	33237326	G	G	33237326	3	3	101	1	0	0	0	0	1	0	0	0	17282	922	32	2	1922	2	VPS52	6	33237326	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08		33237326	137877741	30	19299											
TTBK1	84630	broad.mit.edu	37	chr6	43220516	43220516	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggggctttggtgagatctacGaggccatggacctgctgacc	7	9	15	10	1	1	2	0	2	1	1	1	5	1	3	3	5	2	2	3	5	1	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr6:43220516G>A	uc003ouq.1	+	3	427	c.148G>A	c.(148-150)GAG>AAG	p.E50K		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	50	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TGAGATCTACGAGGCCATGGA	0.592													7	77					0	0	0	0	A	43220516	A	A	43220516	3	1	101	1	0	0	0	0	1	0	0	0	16744	1059	37	1	154	1	TTBK1	6	43220516	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	9983190	43220516	127894551	31	19300											
HSP90AB1	3326	broad.mit.edu	37	chr6	44217204	44217204	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgacatcatccccaaccctCaggaacgtaccctgactttg	10	10	6	15	1	2	2	2	2	0	0	3	3	3	3	4	1	3	1	4	1	3	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr6:44217204C>T	uc003oxa.1	+	3	322	c.238C>T	c.(238-240)CAG>TAG	p.Q80*	HSP90AB1_uc011dvr.1_Nonsense_Mutation_p.Q80*|HSP90AB1_uc003oxb.1_Nonsense_Mutation_p.Q80*|HSP90AB1_uc011dvs.1_5'UTR|HSP90AB1_uc003oxc.1_5'Flank	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	80					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCCCAACCCTCAGGAACGTAC	0.458													11	70					0	0	0	0	T	44217204	T	T	44217204	4	4	101	1	0	0	0	0	0	1	0	0	7441	827	29	2	244	2	HSP90AB1	6	44217204	Nonsense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	996688	44217204	126897863	32	19301											
HSP90AB1	3326	broad.mit.edu	37	chr6	44221083	44221083	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatccccagacccactccaAccgcatctatcgcatgatca	11	7	6	17	2	2	2	1	1	1	1	5	3	4	3	5	1	1	2	5	1	2	1			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr6:44221083A>T	uc003oxa.1	+	11	2117	c.2033A>T	c.(2032-2034)AAC>ATC	p.N678I	HSP90AB1_uc011dvr.1_Missense_Mutation_p.N668I|HSP90AB1_uc003oxb.1_Missense_Mutation_p.N678I|HSP90AB1_uc011dvs.1_Missense_Mutation_p.N498I|HSP90AB1_uc003oxc.1_Missense_Mutation_p.N316I	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	678					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACCCACTCCAACCGCATCTAT	0.488													37	331					0	0	0	0	T	44221083	T	T	44221083	3	4	101	1	0	0	0	0	1	0	0	0	7441	43	2	5	2071	5	HSP90AB1	6	44221083	Missense_Mutation	SNP	A	TCGA-CQ-6219-01A-11D-1912-08	3879	44221083	126893984	33	19302											
EYS	346007	broad.mit.edu	37	chr6	66044987	66044987	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgagaaaacatagatacCgatattcctgactgtcttct	13	13	6	9	1	3	3	0	2	3	2	4	5	4	3	2	0	2	0	2	0	5	5			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr6:66044987C>T	uc011dxu.1	-	11	2190	c.1652G>A	c.(1651-1653)CGG>CAG	p.R551Q	EYS_uc003peq.2_Missense_Mutation_p.R551Q|EYS_uc003per.1_Missense_Mutation_p.R551Q	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	551			R -> L.		response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						ACATAGATACCGATATTCCTG	0.358													9	47					0	0	0	0	T	66044987	T	T	66044987	3	4	101	1	0	0	0	0	1	0	0	0	5357	652	23	1	7876	1	EYS	6	66044987	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	21823904	66044987	105070080	34	19303											
FILIP1	27145	broad.mit.edu	37	chr6	76022996	76022996	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggatacctgtctagaacaGaagatctttccacgggtttc	11	11	10	9	1	2	3	0	0	2	3	4	5	3	4	2	2	2	1	2	2	4	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr6:76022996G>A	uc003pia.2	-	5	2925	c.2552C>T	c.(2551-2553)TCT>TTT	p.S851F	FILIP1_uc003phy.1_Missense_Mutation_p.S851F|FILIP1_uc003phz.2_Missense_Mutation_p.S752F|FILIP1_uc010kbe.2_Missense_Mutation_p.S854F|FILIP1_uc003pib.1_Missense_Mutation_p.S603F	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	851										skin(3)|ovary(1)	4						GTCTAGAACAGAAGATCTTTC	0.453													9	214					0	0	0	0	A	76022996	A	A	76022996	3	1	101	1	0	0	0	0	1	0	0	0	5926	942	33	2	1097	2	FILIP1	6	76022996	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	9978009	76022996	95092071	35	19304											
THSD7A	221981	broad.mit.edu	37	chr7	11676026	11676026	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccacatgcaggctgtacctGagctcctcggcctcgcatgg	6	8	11	16	2	0	1	0	1	0	0	3	1	1	1	4	3	3	5	4	3	1	1			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr7:11676026G>C	uc003ssf.3	-	2	1005	c.753C>G	c.(751-753)CTC>CTG	p.L251L		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	251	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GGCTGTACCTGAGCTCCTCGG	0.607										HNSCC(18;0.044)			15	54					0	0	0	0	C	11676026	C	C	11676026	2	2	101	1	0	0	0	0	0	0	0	1	15945	1277	45	2		2	THSD7A	7	11676026	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08		11676026	147462637	36	19305											
DNAH11	8701	broad.mit.edu	37	chr7	21721264	21721264	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccatagatgtccatgccaGagacgtggtggcaaaactta	13	9	10	9	1	0	2	0	0	0	2	1	3	1	2	3	2	3	1	3	2	5	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr7:21721264G>A	uc003svc.2	+	31	5475	c.5444G>A	c.(5443-5445)AGA>AAA	p.R1815K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1815	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTCCATGCCAGAGACGTGGTG	0.388									Kartagener_syndrome				11	118					0	0	0	0	A	21721264	A	A	21721264	3	1	101	1	0	0	0	0	1	0	0	0	4621	942	33	2	5566	2	DNAH11	7	21721264	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	10045238	21721264	137417399	37	19306											
MRPS33	51650	broad.mit.edu	37	chr7	140710224	140710224	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgtttgtcatcacctgtaGagtccaagaaatcggagcgt	10	12	11	8	2	2	2	2	0	0	2	4	3	3	3	2	1	1	2	2	1	3	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr7:140710224G>C	uc003vwd.3	-	2	366	c.210C>G	c.(208-210)CTC>CTG	p.L70L	MRPS33_uc003vwe.3_Silent_p.L70L	NM_016071	NP_057155	Q9Y291	RT33_HUMAN	mitochondrial ribosomal protein S33	70					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0	Melanoma(164;0.00956)					ATCACCTGTAGAGTCCAAGAA	0.408													13	85					0	0	0	0	C	140710224	C	C	140710224	2	2	101	1	0	0	0	0	0	0	0	1	9895	929	33	2		2	MRPS33	7	140710224	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	118988960	140710224	18428439	38	19307											
PRKDC	5591	broad.mit.edu	37	chr8	48815268	48815268	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcctgctgctgtggtgttaTttgcttaatggaccatttaa	7	17	9	8	0	0	0	0	0	0	0	1	1	1	1	2	2	3	4	2	2	3	5	rs67228297		TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr8:48815268T>C	uc003xqi.2	-	27	3187	c.3130A>G	c.(3130-3132)ATA>GTA	p.I1044V	PRKDC_uc003xqj.2_Missense_Mutation_p.I1044V|PRKDC_uc011ldh.1_Missense_Mutation_p.I1044V	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1044					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGTGGTGTTATTTGCTTAATG	0.433								NHEJ					3	52					0	0	0	0	C	48815268	C	C	48815268	3	2	101	1	0	0	0	0	1	0	0	0	12583	1493	52	5	9495	5	PRKDC	8	48815268	Missense_Mutation	SNP	T	TCGA-CQ-6219-01A-11D-1912-08		48815268	97548754	39	19308											
PHF20L1	51105	broad.mit.edu	37	chr8	133823320	133823320	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catccaaagctgttggggttGatggtgctgaaaaaaaggaa	14	9	13	5	0	0	2	0	2	0	0	1	3	1	3	1	4	2	4	1	4	5	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr8:133823320G>C	uc003ytt.2	+	9	1202	c.877G>C	c.(877-879)GAT>CAT	p.D293H	PHF20L1_uc003ytr.2_Missense_Mutation_p.D267H|PHF20L1_uc010mdv.2_Missense_Mutation_p.D267H|PHF20L1_uc003yts.2_Missense_Mutation_p.D293H|PHF20L1_uc011lja.1_Missense_Mutation_p.D267H|PHF20L1_uc003ytu.1_RNA|PHF20L1_uc003ytv.2_Missense_Mutation_p.D132H	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	293							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGTTGGGGTTGATGGTGCTGA	0.363													29	88					0	0	0	0	C	133823320	C	C	133823320	3	2	101	1	0	0	0	0	1	0	0	0	11887	1290	45	2	907	2	PHF20L1	8	133823320	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	85008052	133823320	12540702	40	19309											
UBAP2	55833	broad.mit.edu	37	chr9	33932597	33932597	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggagagggctgcatgtgcaGagaggctgctctggtggctg	7	8	19	7	0	1	2	0	0	1	2	1	4	1	2	0	5	3	6	0	5	0	0			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr9:33932597G>C	uc003ztq.1	-	19	2251	c.2138C>G	c.(2137-2139)TCT>TGT	p.S713C	UBAP2_uc011loc.1_Missense_Mutation_p.S622C|UBAP2_uc011lod.1_Missense_Mutation_p.S446C|UBAP2_uc011loe.1_Missense_Mutation_p.S468C|UBAP2_uc011lof.1_Missense_Mutation_p.S638C|UBAP2_uc011log.1_Intron|UBAP2_uc003zto.1_5'UTR|UBAP2_uc003ztp.1_5'UTR|SNORD121B_uc011loh.1_5'Flank	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	713										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TGCATGTGCAGAGAGGCTGCT	0.567													3	30					0	0	0	0	C	33932597	C	C	33932597	3	2	101	1	0	0	0	0	1	0	0	0	16905	942	33	2	1265	2	UBAP2	9	33932597	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08		33932597	107280834	41	19310											
CCIN	881	broad.mit.edu	37	chr9	36170053	36170053	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatctttggccgcctgctccGtgatgaaaaccttcacgtgc	7	12	9	13	3	2	2	1	2	1	0	3	2	3	2	4	1	3	1	4	1	3	3	rs142822017		TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr9:36170053G>A	uc003zzb.3	+	1	665	c.554G>A	c.(553-555)CGT>CAT	p.R185H		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	185	BACK.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			CGCCTGCTCCGTGATGAAAAC	0.537													7	45					0	0	0	0	A	36170053	A	A	36170053	3	1	101	1	0	0	0	0	1	0	0	0	2891	1145	40	1	556	1	CCIN	9	36170053	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	2237456	36170053	105043378	42	19311											
FAM120AOS	158293	broad.mit.edu	37	chr9	96214605	96214605	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcaccccgccgccaaaggtCtggttcctgccgcccgtctg	4	7	12	18	4	2	0	0	0	2	0	3	0	3	0	7	3	1	2	7	3	1	1			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr9:96214605C>G	uc004atu.3	-	1	1270	c.387G>C	c.(385-387)CAG>CAC	p.Q129H	FAM120AOS_uc004atm.2_5'Flank|FAM120AOS_uc004atn.3_5'Flank|FAM120AOS_uc004ato.3_5'Flank|FAM120AOS_uc004atp.3_5'Flank|FAM120AOS_uc004atq.3_5'Flank|FAM120AOS_uc004atr.3_5'Flank|FAM120AOS_uc004ats.3_Intron|FAM120AOS_uc004att.3_Intron|FAM120A_uc004atv.2_Silent_p.V136V|FAM120A_uc004atw.2_Silent_p.V136V	NM_198841	NP_942138	Q5T036	F120S_HUMAN	hypothetical protein LOC158293	129											0						CGCCAAAGGTCTGGTTCCTGC	0.607													4	29					0	0	0	0	G	96214605	G	G	96214605	3	3	101	1	0	0	0	0	1	0	0	0	5444	912	32	2	395	2	FAM120AOS	9	96214605	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	60044552	96214605	44998826	43	19312											
COL15A1	1306	broad.mit.edu	37	chr9	101748163	101748163	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggatcatcctctactacacGgagccaggctcccatgtgtc	8	9	9	15	2	2	0	1	0	1	0	5	2	4	2	3	3	3	1	3	3	2	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr9:101748163G>A	uc004azb.1	+	3	623	c.417G>A	c.(415-417)ACG>ACA	p.T139T	COL15A1_uc004aza.2_Silent_p.T139T	NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	139	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TCTACTACACGGAGCCAGGCT	0.607													29	87					0	0	0	0	A	101748163	A	A	101748163	2	1	101	1	0	0	0	0	0	0	0	1	3687	1103	39	1		1	COL15A1	9	101748163	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	5533558	101748163	39465268	44	19313											
SMC2	10592	broad.mit.edu	37	chr9	106896745	106896745	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tactcttttgcctggtgctaAtgctatgcttgcaccaccag	7	14	8	12	0	1	0	0	0	1	0	1	0	1	0	3	1	6	4	3	1	3	6			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr9:106896745A>G	uc004bbv.2	+	23	3446	c.3158A>G	c.(3157-3159)AAT>AGT	p.N1053S	SMC2_uc004bbw.2_Missense_Mutation_p.N1053S|SMC2_uc011lvl.1_Missense_Mutation_p.N1053S|SMC2_uc004bbx.2_Missense_Mutation_p.N1053S|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	1053					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						CCTGGTGCTAATGCTATGCTT	0.393													5	54					0	0	0	0	G	106896745	G	G	106896745	3	3	101	1	0	0	0	0	1	0	0	0	14847	101	4	5	3244	5	SMC2	9	106896745	Missense_Mutation	SNP	A	TCGA-CQ-6219-01A-11D-1912-08	5148582	106896745	34316686	45	19314											
DAB2IP	153090	broad.mit.edu	37	chr9	124522377	124522377	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtcactgtccacctgtacCgggagaccgacaagaagaag	12	5	12	12	3	1	3	1	0	0	3	2	5	2	3	4	2	1	1	4	2	4	1			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr9:124522377C>T	uc004bln.2	+	6	814	c.745C>T	c.(745-747)CGG>TGG	p.R249W	DAB2IP_uc004blo.2_Missense_Mutation_p.R153W	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	277	C2.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						CCACCTGTACCGGGAGACCGA	0.612													12	80					0	0	0	0	T	124522377	T	T	124522377	3	4	101	1	0	0	0	0	1	0	0	0	4236	643	23	1	767	1	DAB2IP	9	124522377	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	17625632	124522377	16691054	46	19315											
NOTCH1	4851	broad.mit.edu	37	chr9	139413084	139413084	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagtagaaggaggccacaCggtcatggcaggtggcgccg	9	4	17	11	4	1	1	1	0	0	1	1	2	1	2	2	6	0	3	2	6	2	1			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr9:139413084C>T	uc004chz.2	-	6	1058	c.1058G>A	c.(1057-1059)CGT>CAT	p.R353H		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	353	Extracellular (Potential).|EGF-like 9; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.R353H(2)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGAGGCCACACGGTCATGGCA	0.647			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			5	15					0	0	0	0	T	139413084	T	T	139413084	3	4	101	1	0	0	0	0	1	0	0	0	10601	536	19	1	6725	1	NOTCH1	9	139413084	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	14890707	139413084	1800347	47	19316											
TSPAN14	81619	broad.mit.edu	37	chr10	82264528	82264528	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcgggctgtgggcatggagCgaaaaggtaggtgtaactgt	9	9	18	5	2	0	0	0	0	0	0	1	2	0	1	0	5	2	4	0	5	4	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr10:82264528C>T	uc001kcj.3	+	3	233	c.126C>T	c.(124-126)AGC>AGT	p.S42S	TSPAN14_uc009xss.2_Intron|TSPAN14_uc001kci.3_Intron	NM_030927	NP_112189	Q8NG11	TSN14_HUMAN	tetraspanin 14 isoform 1	42						integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)			GGGCATGGAGCGAAAAGGTAG	0.517													16	86					0	0	0	0	T	82264528	T	T	82264528	2	4	101	1	0	0	0	0	0	0	0	1	16705	767	27	1		1	TSPAN14	10	82264528	Silent	SNP	C	TCGA-CQ-6219-01A-11D-1912-08		82264528	53270219	48	19317											
MICALCL	84953	broad.mit.edu	37	chr11	12313774	12313774	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccttcatcgtcttcccattCatcttccccaccatcttctt	5	17	1	18	1	6	0	2	0	4	0	10	0	9	0	5	0	0	0	5	0	0	6			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr11:12313774C>T	uc001mkg.1	+	2	350	c.59C>T	c.(58-60)TCA>TTA	p.S20L		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	20	Ser-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		tcttcccattcatcttcccca	0.363													10	49					0	0	0	0	T	12313774	T	T	12313774	3	4	101	1	0	0	0	0	1	0	0	0	9625	838	29	2	61	2	MICALCL	11	12313774	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08		12313774	122692742	49	19318											
ABTB2	25841	broad.mit.edu	37	chr11	34182611	34182611	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagagactcgatccagatgtGcagcttccaggggactcctg	9	8	12	12	1	0	2	0	0	0	2	4	5	3	3	3	2	2	2	3	2	0	1			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr11:34182611G>A	uc001mvl.1	-	11	1908	c.1678C>T	c.(1678-1680)CAC>TAC	p.H560Y		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	560							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				ATCCAGATGTGCAGCTTCCAG	0.622													4	17					0	0	0	0	A	34182611	A	A	34182611	3	1	101	1	0	0	0	0	1	0	0	0	103	1319	46	4	869	4	ABTB2	11	34182611	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	21868837	34182611	100823905	50	19319											
SIDT2	51092	broad.mit.edu	37	chr11	117056884	117056884	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatgctcttttgcctgggtAtatttctctccttttacctg	4	19	8	10	0	2	0	0	0	2	0	4	1	3	1	3	2	3	2	3	2	3	7			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr11:117056884A>G	uc001pqh.1	+	9	948	c.907A>G	c.(907-909)ATA>GTA	p.I303V	SIDT2_uc010rxe.1_Missense_Mutation_p.I303V|SIDT2_uc001pqg.2_Missense_Mutation_p.I303V|SIDT2_uc001pqi.1_Missense_Mutation_p.I303V	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	303	Helical; (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		TTGCCTGGGTATATTTCTCTC	0.557													18	93					0	0	0	0	G	117056884	G	G	117056884	3	3	101	1	0	0	0	0	1	0	0	0	14368	449	16	5	941	5	SIDT2	11	117056884	Missense_Mutation	SNP	A	TCGA-CQ-6219-01A-11D-1912-08	82874273	117056884	17949632	51	19320											
HIST4H4	121504	broad.mit.edu	37	chr12	14923813	14923813	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccgtgtaagtcaccgcgTcacggatcacgttctccagg	7	9	11	14	5	4	0	3	0	1	0	6	1	5	1	3	2	0	3	3	2	1	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr12:14923813T>C	uc001rcf.3	-	1	253	c.206A>G	c.(205-207)GAC>GGC	p.D69G	HIST4H4_uc001rce.2_RNA	NM_175054	NP_778224	P62805	H4_HUMAN	histone cluster 4, H4	69					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						AGTCACCGCGTCACGGATCAC	0.617											OREG0021698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	85					0	0	0	0	C	14923813	C	C	14923813	3	2	101	1	0	0	0	0	1	0	0	0	7224	1667	58	5	109	5	HIST4H4	12	14923813	Missense_Mutation	SNP	T	TCGA-CQ-6219-01A-11D-1912-08		14923813	118928082	52	19321											
KRT6A	3853	broad.mit.edu	37	chr12	52886867	52886867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggagcgggacacggagaCgctgctgaagccagagcggc	9	3	17	12	4	0	3	0	1	0	2	0	6	0	5	2	4	4	2	2	4	1	0			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr12:52886867C>T	uc001sam.2	-	1	315	c.106G>A	c.(106-108)GTC>ATC	p.V36I		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	36	Head.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		GACACGGAGACGCTGCTGAAG	0.667													5	105					0	0	0	0	T	52886867	T	T	52886867	3	4	101	1	0	0	0	0	1	0	0	0	8519	536	19	1	1624	1	KRT6A	12	52886867	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	37963054	52886867	80965028	53	19322											
COG3	83548	broad.mit.edu	37	chr13	46070356	46070356	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtacaggagcggctcgtctAccgaacccacatctatattc	10	10	8	13	3	2	0	0	0	2	0	4	2	2	1	2	2	4	2	2	2	5	5			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr13:46070356A>T	uc001vak.2	+	13	1498	c.1397A>T	c.(1396-1398)TAC>TTC	p.Y466F	COG3_uc001vaj.1_Missense_Mutation_p.Y466F|COG3_uc010tfv.1_Missense_Mutation_p.Y303F|COG3_uc010aci.2_Missense_Mutation_p.Y242F	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	466					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		CGGCTCGTCTACCGAACCCAC	0.468													6	30					0	0	0	0	T	46070356	T	T	46070356	3	4	101	1	0	0	0	0	1	0	0	0	3674	391	14	5	1447	5	COG3	13	46070356	Missense_Mutation	SNP	A	TCGA-CQ-6219-01A-11D-1912-08		46070356	69099522	54	19323											
RPGRIP1	57096	broad.mit.edu	37	chr14	21795832	21795832	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacccaacggatctattcaaGtgcaactggattggaagttt	13	11	9	8	1	2	0	1	0	1	0	2	3	2	3	1	3	4	2	1	3	6	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr14:21795832G>A	uc001wag.2	+	17	2761	c.2761G>A	c.(2761-2763)GTG>ATG	p.V921M	RPGRIP1_uc001wah.2_Missense_Mutation_p.V563M|RPGRIP1_uc001wai.2_Missense_Mutation_p.V247M|RPGRIP1_uc001wak.2_Missense_Mutation_p.V396M|RPGRIP1_uc010aim.2_Missense_Mutation_p.V304M|RPGRIP1_uc001wal.2_Missense_Mutation_p.V280M|RPGRIP1_uc001wam.2_Missense_Mutation_p.V238M	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	921					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		ATCTATTCAAGTGCAACTGGA	0.433													12	55					0	0	0	0	A	21795832	A	A	21795832	3	1	101	1	0	0	0	0	1	0	0	0	13614	1029	36	4	2827	4	RPGRIP1	14	21795832	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08		21795832	85553708	55	19324											
ATP5S	27109	broad.mit.edu	37	chr14	50798919	50798919	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagccacaactgccatcctCaagtctagattccaactctc	13	9	4	15	0	3	1	1	0	2	1	6	1	5	1	4	0	4	0	4	0	5	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr14:50798919C>G	uc010ant.1	+	5	666	c.666C>G	c.(664-666)CTC>CTG	p.L222L	CDKL1_uc001wxz.2_Intron	NM_001003803	NP_001003803	Q99766	ATP5S_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	Error:Variant_position_missing_in_Q99766_after_alignment					ATP biosynthetic process	mitochondrial inner membrane|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			ovary(1)|skin(1)	2	all_epithelial(31;0.000636)|Breast(41;0.0102)			OV - Ovarian serous cystadenocarcinoma(311;0.0685)		CTGCCATCCTCAAGTCTAGAT	0.483													4	71					0	0	0	0	G	50798919	G	G	50798919	2	3	101	1	0	0	0	0	0	0	0	1	1165	841	29	2		2	ATP5S	14	50798919	Silent	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	29003087	50798919	56550621	56	19325											
EML5	161436	broad.mit.edu	37	chr14	89124674	89124674	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctgtcatcataagtccagCgaacatttgtgacatgtgta	11	13	9	8	1	2	1	2	1	0	0	3	2	3	1	1	0	3	2	1	0	3	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr14:89124674C>T	uc001xxg.2	-	27	3920	c.3734G>A	c.(3733-3735)CGC>CAC	p.R1245H	EML5_uc001xxf.2_Missense_Mutation_p.R40H|EML5_uc001xxh.1_Missense_Mutation_p.R384H	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1245	WD 19.					cytoplasm|microtubule				ovary(3)	3						ATAAGTCCAGCGAACATTTGT	0.398													7	135					0	0	0	0	T	89124674	T	T	89124674	3	4	101	1	0	0	0	0	1	0	0	0	5124	768	27	1	2271	1	EML5	14	89124674	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	38325755	89124674	18224866	57	19326											
KLHL25	64410	broad.mit.edu	37	chr15	86312762	86312762	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagctccagcacctccgggtGcaggttgtcctggaagttga	7	9	13	12	1	0	1	0	1	0	0	3	2	3	2	4	3	3	5	4	3	1	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr15:86312762G>T	uc002bly.2	-	2	483	c.280C>A	c.(280-282)CAC>AAC	p.H94N		NM_022480	NP_071925	Q9H0H3	ENC2_HUMAN	BTB/POZ KELCH domain protein	94	BTB.					cytoplasm				ovary(2)	2						ACCTCCGGGTGCAGGTTGTCC	0.612													4	73					0.00024832	0.000309311	1	0	T	86312762	T	T	86312762	3	4	101	1	0	0	0	0	1	0	0	0	8419	1319	46	4	1493	4	KLHL25	15	86312762	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08		86312762	16218630	58	19327											
MEFV	4210	broad.mit.edu	37	chr16	3293648	3293648	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acactcttcagatcatcagaGaagatgaggttggggtaagc	13	9	12	7	0	4	4	3	1	1	3	4	5	4	4	0	3	1	2	0	3	2	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr16:3293648G>C	uc002cun.1	-	10	1879	c.1839C>G	c.(1837-1839)TTC>TTG	p.F613L		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	613	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	GATCATCAGAGAAGATGAGGT	0.473													42	282					0	0	0	0	C	3293648	C	C	3293648	3	2	101	1	0	0	0	0	1	0	0	0	9512	933	33	2	510	2	MEFV	16	3293648	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08		3293648	87061105	59	19328											
BTBD12	84464	broad.mit.edu	37	chr16	3640079	3640079	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaaaacagctcacaggacCtagggctaatttctagagct	13	9	10	9	0	2	1	1	0	1	1	2	3	2	3	1	3	3	3	1	3	5	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr16:3640079C>A	uc002cvp.2	-	12	4187	c.3560G>T	c.(3559-3561)AGG>ATG	p.R1187M		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1187	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CTCACAGGACCTAGGGCTAAT	0.483								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				15	117					2.31682e-05	2.9374e-05	1	0	A	3640079	A	A	3640079	3	1	101	1	0	0	0	0	1	0	0	0	1545	681	24	4	1960	4	BTBD12	16	3640079	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	346431	3640079	86714674	60	19329											
TRAP1	10131	broad.mit.edu	37	chr16	3724418	3724418	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtgtagcggggcttgtcGtgagcctgcgcgacgtagcg	5	8	19	9	6	0	1	0	1	0	0	1	2	0	1	1	3	4	3	1	3	2	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr16:3724418G>A	uc002cvt.3	-	9	1055	c.966C>T	c.(964-966)CAC>CAT	p.H322H	TRAP1_uc002cvs.2_Silent_p.H113H|TRAP1_uc010uxf.1_Silent_p.H269H	NM_016292	NP_057376	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1 precursor	322					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(1)	1		Ovarian(90;0.0261)				GGGGCTTGTCGTGAGCCTGCG	0.602													5	61					0	0	0	0	A	3724418	A	A	3724418	2	1	101	1	0	0	0	0	0	0	0	1	16522	1136	40	1		1	TRAP1	16	3724418	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	84339	3724418	86630335	61	19330											
ITGAX	3687	broad.mit.edu	37	chr16	31373519	31373520	+	Frame_Shift_Ins	INS	-	A	A																															tgtggacatgagggactcttINSacctgggtgagaaacagcca																										TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr16:31373519_31373520insA	uc002ebu.1	+	11	1277_1278	c.1210_1211insA	c.(1210-1212)TACfs	p.Y404fs	ITGAX_uc002ebt.2_Frame_Shift_Ins_p.Y404fs|ITGAX_uc010vfk.1_Frame_Shift_Ins_p.Y54fs	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	404	FG-GAP 4.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GAGGGACTCTTACCTGGGTGAG	0.599													---	---	---								A	31373520	A	A	31373519	7	5	101	1	0	1	1	0	0	0	0	0	7928	1754	61	0	1252	0	ITGAX	16	31373519	Frame_Shift_Ins	INS	-	TCGA-CQ-6219-01A-11D-1912-08	27649101	31373519	58981234	62	19331											
CDT1	81620	broad.mit.edu	37	chr16	88871192	88871192	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccatctctgagcttgcgtCatgcctgcaacgggcccggg	6	8	12	15	3	2	1	1	1	1	0	3	1	2	1	3	2	5	2	3	2	1	1			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr16:88871192C>T	uc002flu.2	+	3	428	c.374C>T	c.(373-375)TCA>TTA	p.S125L		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	125					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		GAGCTTGCGTCATGCCTGCAA	0.706													4	32					0	0	0	0	T	88871192	T	T	88871192	3	4	101	1	0	0	0	0	1	0	0	0	3195	838	29	2	384	2	CDT1	16	88871192	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	57497673	88871192	1483561	63	19332											
RPA1	6117	broad.mit.edu	37	chr17	1782859	1782859	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcatgtgttttagacatcAtcgggatctgcaagagctat	10	13	11	7	1	2	2	1	0	1	2	3	3	2	3	0	1	3	4	0	1	3	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr17:1782859A>G	uc002fto.2	+	11	1073	c.958A>G	c.(958-960)ATC>GTC	p.I320V		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	320					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TTTAGACATCATCGGGATCTG	0.493								NER					52	91					0	0	0	0	G	1782859	G	G	1782859	3	3	101	1	0	0	0	0	1	0	0	0	13601	217	8	5	1000	5	RPA1	17	1782859	Missense_Mutation	SNP	A	TCGA-CQ-6219-01A-11D-1912-08		1782859	79412351	64	19333											
TP53	7157	broad.mit.edu	37	chr17	7578211	7578211	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agggcaccaccacactatgtCgaaaagtgtttctgtcatcc	11	10	8	12	1	2	0	1	0	1	0	4	1	3	0	3	1	0	2	3	1	3	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr17:7578211C>G	uc002gim.2	-	6	832	c.638G>C	c.(637-639)CGA>CCA	p.R213P	TP53_uc002gig.1_Missense_Mutation_p.R213P|TP53_uc002gih.2_Missense_Mutation_p.R213P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R81P|TP53_uc010cng.1_Missense_Mutation_p.R81P|TP53_uc002gii.1_Missense_Mutation_p.R81P|TP53_uc010cnh.1_Missense_Mutation_p.R213P|TP53_uc010cni.1_Missense_Mutation_p.R213P|TP53_uc002gij.2_Missense_Mutation_p.R213P|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.R120P|TP53_uc002gio.2_Missense_Mutation_p.R81P|TP53_uc010vug.1_Missense_Mutation_p.R174P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(182)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACACTATGTCGAAAAGTGTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	31					0	0	0	0	G	7578211	G	G	7578211	3	3	101	1	0	0	0	0	1	0	0	0	16448	884	31	3	656	3	TP53	17	7578211	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	5795352	7578211	73616999	65	19334											
FLII	2314	broad.mit.edu	37	chr17	18156755	18156755	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacagcttcttcagcttgctCagcttgcaaatggctgactg	8	13	9	11	0	3	1	2	1	1	0	3	1	3	1	0	1	6	6	0	1	2	5			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr17:18156755C>G	uc002gsr.1	-	9	924	c.873G>C	c.(871-873)CTG>CTC	p.L291L	FLII_uc002gsq.1_Silent_p.L163L|FLII_uc010cpy.1_Silent_p.L280L|FLII_uc010vxn.1_Silent_p.L260L|FLII_uc010vxo.1_Silent_p.L237L|FLII_uc002gss.1_Silent_p.L291L	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	291	LRR 12.|Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					TCAGCTTGCTCAGCTTGCAAA	0.602													3	102					0	0	0	0	G	18156755	G	G	18156755	2	3	101	1	0	0	0	0	0	0	0	1	5957	813	29	2		2	FLII	17	18156755	Silent	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	10578544	18156755	63038455	66	19335											
MYO1D	4642	broad.mit.edu	37	chr17	31099821	31099821	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actaacctgatagaaagaatGaaagcttctttctcctggct	13	12	7	9	0	2	4	0	2	2	2	3	4	2	4	2	1	2	2	2	1	5	4	rs140725997		TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr17:31099821G>T	uc002hho.1	-	5	616	c.604C>A	c.(604-606)CAT>AAT	p.H202N	MYO1D_uc002hhp.1_Missense_Mutation_p.H202N|MYO1D_uc010wcb.1_Missense_Mutation_p.H202N	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	202	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			TAGAAAGAATGAAAGCTTCTT	0.388													19	157					1.40151e-16	1.84273e-16	1	0	T	31099821	T	T	31099821	3	4	101	1	0	0	0	0	1	0	0	0	10124	1290	45	2	2488	2	MYO1D	17	31099821	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	12943066	31099821	50095389	67	19336											
ACACA	31	broad.mit.edu	37	chr17	35545260	35545260	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccttgtataggctgataTccaagtaatagccagactcg	11	12	8	10	1	0	2	0	1	0	1	3	2	2	2	3	1	1	3	3	1	6	7			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr17:35545260T>C	uc002hnm.2	-	39	4813	c.4622A>G	c.(4621-4623)GAT>GGT	p.D1541G	ACACA_uc002hnk.2_Missense_Mutation_p.D1463G|ACACA_uc002hnl.2_Missense_Mutation_p.D1483G|ACACA_uc002hnn.2_Missense_Mutation_p.D1541G|ACACA_uc002hno.2_Missense_Mutation_p.D1578G|ACACA_uc010cuy.2_Missense_Mutation_p.D235G	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1541					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TAGGCTGATATCCAAGTAATA	0.468													3	46					0	0	0	0	C	35545260	C	C	35545260	3	2	101	1	0	0	0	0	1	0	0	0	106	1435	50	5	2490	5	ACACA	17	35545260	Missense_Mutation	SNP	T	TCGA-CQ-6219-01A-11D-1912-08	4445439	35545260	45649950	68	19337											
MED1	5469	broad.mit.edu	37	chr17	37571363	37571363	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttacagctcacatgtgttGagtcctgcacatccattacc	9	13	7	12	0	1	1	1	1	0	0	3	1	3	1	3	0	4	4	3	0	2	4	rs1139821		TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr17:37571363G>C	uc002hrv.3	-	16	1627	c.1415C>G	c.(1414-1416)TCA>TGA	p.S472*	MED1_uc010wee.1_Nonsense_Mutation_p.S300*|MED1_uc002hru.2_Nonsense_Mutation_p.S472*	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	472	Interaction with ESR1.|Interaction with THRA.|Interaction with the Mediator complex and THRA.			DS -> GL (in Ref. 1; CAA73867).	androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		CACATGTGTTGAGTCCTGCAC	0.418										HNSCC(31;0.082)			23	286					0	0	0	0	C	37571363	C	C	37571363	4	2	101	1	0	0	0	0	0	1	0	0	9478	1294	45	2	3338	2	MED1	17	37571363	Nonsense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	2026103	37571363	43623847	69	19338											
HOXB2	3212	broad.mit.edu	37	chr17	46622170	46622170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtcgactccttgattgatGaagtttgaaatgtctccaag	11	14	9	7	1	1	4	0	4	1	0	4	5	2	4	2	0	0	1	2	0	3	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr17:46622170G>A	uc002inm.2	-	1	224	c.104C>T	c.(103-105)TCA>TTA	p.S35L		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	35					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTTGATTGATGAAGTTTGAAA	0.527													13	86					0	0	0	0	A	46622170	A	A	46622170	3	1	101	1	0	0	0	0	1	0	0	0	7340	1294	45	2	974	2	HOXB2	17	46622170	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	9050807	46622170	34573040	70	19339											
BPTF	2186	broad.mit.edu	37	chr17	65889610	65889610	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaagtatcgcgtctaccacaAtcaatactccaccaattcat	14	10	4	13	2	3	0	2	0	1	0	5	1	4	0	3	0	2	1	3	0	7	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr17:65889610A>G	uc002jgf.2	+	6	2241	c.2180A>G	c.(2179-2181)AAT>AGT	p.N727S	BPTF_uc002jge.2_Missense_Mutation_p.N853S|BPTF_uc010wqm.1_Missense_Mutation_p.N790S	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	853	Interaction with MAZ.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GTCTACCACAATCAATACTCC	0.393													5	55					0	0	0	0	G	65889610	G	G	65889610	3	3	101	1	0	0	0	0	1	0	0	0	1500	101	4	5	2588	5	BPTF	17	65889610	Missense_Mutation	SNP	A	TCGA-CQ-6219-01A-11D-1912-08	19267440	65889610	15305600	71	19340											
KCNJ2	3759	broad.mit.edu	37	chr17	68172279	68172279	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acttagcagaaaagaaatatAtcctctcaaatgcaaattca	19	10	4	8	0	2	2	2	0	1	2	4	2	3	2	1	0	2	2	1	0	8	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr17:68172279A>G	uc010dfg.2	+	2	1500	c.1099A>G	c.(1099-1101)ATC>GTC	p.I367V	KCNJ2_uc002jir.2_Missense_Mutation_p.I367V	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	367	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					AAAGAAATATATCCTCTCAAA	0.413													20	123					0	0	0	0	G	68172279	G	G	68172279	3	3	101	1	0	0	0	0	1	0	0	0	8090	449	16	5	1101	5	KCNJ2	17	68172279	Missense_Mutation	SNP	A	TCGA-CQ-6219-01A-11D-1912-08	2282669	68172279	13022931	72	19341											
RNF157	114804	broad.mit.edu	37	chr17	74161588	74161588	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctaaagtcactcaccttctCaaaagtacccagcagtacat	14	10	4	13	0	4	0	3	0	2	0	5	0	4	0	2	0	3	3	2	0	6	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr17:74161588C>G	uc002jqz.2	-	7	736	c.667G>C	c.(667-669)GAG>CAG	p.E223Q	RNF157_uc002jra.2_Missense_Mutation_p.E223Q	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	223							zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			CTCACCTTCTCAAAAGTACCC	0.483													12	144					0	0	0	0	G	74161588	G	G	74161588	3	3	101	1	0	0	0	0	1	0	0	0	13519	835	29	2	1424	2	RNF157	17	74161588	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	5989309	74161588	7033622	73	19342											
DLGAP1	9229	broad.mit.edu	37	chr18	3879519	3879519	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccgcgcgccgctccttgcTcttgctgcgtttgccatagc	2	12	10	17	5	1	0	0	0	1	0	3	0	3	0	4	0	5	4	4	0	1	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr18:3879519T>G	uc002kmf.2	-	1	617	c.550A>C	c.(550-552)AGC>CGC	p.S184R	DLGAP1_uc010wyz.1_Missense_Mutation_p.S184R|DLGAP1_uc002kmk.2_Missense_Mutation_p.S184R|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	184					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CGCTCCTTGCTCTTGCTGCGT	0.697													12	120					0	0	0	0	G	3879519	G	G	3879519	3	3	101	1	0	0	0	0	1	0	0	0	4581	1551	54	5	2478	5	DLGAP1	18	3879519	Missense_Mutation	SNP	T	TCGA-CQ-6219-01A-11D-1912-08		3879519	74197729	74	19343											
ANKRD12	23253	broad.mit.edu	37	chr18	9257921	9257921	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatacttttgtcctaggAgatgttcaaaaaacagatgc	16	11	8	6	0	1	2	1	0	0	2	2	4	2	2	1	1	3	1	1	1	7	5			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr18:9257921A>T	uc002knv.2	+	9	4913	c.4656A>T	c.(4654-4656)GGA>GGT	p.G1552G	ANKRD12_uc002knw.2_Silent_p.G1529G|ANKRD12_uc002knx.2_Silent_p.G1529G|ANKRD12_uc010dkx.1_Silent_p.G1259G	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1552						nucleus				ovary(2)|central_nervous_system(1)	3						TTGTCCTAGGAGATGTTCAAA	0.338													10	30					0	0	0	0	T	9257921	T	T	9257921	2	4	101	1	0	0	0	0	0	0	0	1	640	291	11	5		5	ANKRD12	18	9257921	Silent	SNP	A	TCGA-CQ-6219-01A-11D-1912-08	5378402	9257921	68819327	75	19344											
MALT1	10892	broad.mit.edu	37	chr18	56400691	56400691	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagcttcatggtccccgttGatgctccaaatccatatagg	10	11	8	12	1	1	1	1	1	0	0	4	1	4	1	4	2	2	3	4	2	3	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr18:56400691G>A	uc002lhm.1	+	11	1543	c.1285G>A	c.(1285-1287)GAT>AAT	p.D429N	MALT1_uc002lhn.1_Missense_Mutation_p.D418N	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	429	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						GGTCCCCGTTGATGCTCCAAA	0.343			T	BIRC3	MALT								7	85					0	0	0	0	A	56400691	A	A	56400691	3	1	101	1	0	0	0	0	1	0	0	0	9255	1290	45	2	1327	2	MALT1	18	56400691	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	47142770	56400691	21676557	76	19345											
INSR	3643	broad.mit.edu	37	chr19	7184590	7184590	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaacagttgcccaggcactcGctgtggcaacagaggccttc	9	7	12	13	1	0	1	0	0	0	1	2	2	0	1	2	3	3	4	2	3	2	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr19:7184590G>A	uc002mgd.1	-	3	820	c.711C>T	c.(709-711)AGC>AGT	p.S237S	INSR_uc002mge.1_Silent_p.S237S|INSR_uc002mgf.2_Silent_p.S237S	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	237	Cys-rich.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCAGGCACTCGCTGTGGCAAC	0.522													4	42					0	0	0	0	A	7184590	A	A	7184590	2	1	101	1	0	0	0	0	0	0	0	1	7812	1078	38	1		1	INSR	19	7184590	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08		7184590	51944393	77	19346											
CCDC130	81576	broad.mit.edu	37	chr19	13873753	13873753	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agcccgagggggcaggaaggGagccgtcaggacaagcccct	10	2	17	12	2	1	0	1	0	0	0	1	4	1	3	4	5	3	1	4	5	2	0			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr19:13873753G>C	uc002mxb.1	+	11	1565	c.1062G>C	c.(1060-1062)GGG>GGC	p.G354G	CCDC130_uc002mxc.1_Silent_p.G354G|CCDC130_uc002mxd.1_Silent_p.G209G|CCDC130_uc010dzf.1_Silent_p.G248G|MRI1_uc002mxe.2_5'Flank|MRI1_uc002mxf.2_5'Flank	NM_030818	NP_110445	P13994	CC130_HUMAN	coiled-coil domain containing 130	354					response to virus		protein binding				0			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			GGCAGGAAGGGAGCCGTCAGG	0.692													6	21					0	0	0	0	C	13873753	C	C	13873753	2	2	101	1	0	0	0	0	0	0	0	1	2778	1161	41	2		2	CCDC130	19	13873753	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	6689163	13873753	45255230	78	19347											
MRI1	84245	broad.mit.edu	37	chr19	13879659	13879659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtcgtgggagctgaccGcgtggttgccaacggcgaca	6	8	17	10	5	0	1	0	1	0	0	1	3	0	2	2	4	3	2	2	4	1	1			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr19:13879659G>A	uc002mxe.2	+	5	812	c.746G>A	c.(745-747)CGC>CAC	p.R249H	MRI1_uc002mxf.2_Missense_Mutation_p.R202H	NM_001031727	NP_001026897	Q9BV20	MTNA_HUMAN	translation initiation factor eIF-2B subunit	249					L-methionine salvage from methylthioadenosine	cell projection|cytoplasm|nucleus	identical protein binding|S-methyl-5-thioribose-1-phosphate isomerase activity			ovary(1)	1						GGAGCTGACCGCGTGGTTGCC	0.652													6	33					0	0	0	0	A	13879659	A	A	13879659	3	1	101	1	0	0	0	0	1	0	0	0	9823	1087	38	1	857	1	MRI1	19	13879659	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	5906	13879659	45249324	79	19348											
ZNF430	80264	broad.mit.edu	37	chr19	21239599	21239599	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taatctgcacaaagaatgttAtgatgaactaaaccagtgtt	16	12	7	6	0	1	3	0	2	1	1	1	3	1	3	1	0	3	3	1	0	7	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr19:21239599A>T	uc002npj.2	+	5	595	c.485A>T	c.(484-486)TAT>TTT	p.Y162F	ZNF430_uc002npk.2_Missense_Mutation_p.Y161F	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						AAAGAATGTTATGATGAACTA	0.303													4	31					0	0	0	0	T	21239599	T	T	21239599	3	4	101	1	0	0	0	0	1	0	0	0	17971	449	16	5	503	5	ZNF430	19	21239599	Missense_Mutation	SNP	A	TCGA-CQ-6219-01A-11D-1912-08	7359940	21239599	37889384	80	19349											
PAK7	57144	broad.mit.edu	37	chr20	9520158	9520158	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggacgatgcaagacggtggaCctgctagttttaagaatgga	12	9	14	6	2	0	2	0	0	0	2	0	6	0	5	1	4	2	3	1	4	4	3			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr20:9520158C>A	uc002wnl.2	-	11	2656	c.2111G>T	c.(2110-2112)GGT>GTT	p.G704V	PAK7_uc002wnk.2_Missense_Mutation_p.G704V|PAK7_uc002wnj.2_Missense_Mutation_p.G704V|PAK7_uc010gby.1_Missense_Mutation_p.G617V	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	704			G -> S (in a metastatic melanoma sample; somatic mutation).				ATP binding|protein binding|protein serine/threonine kinase activity	p.G704S(1)		lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			AGACGGTGGACCTGCTAGTTT	0.512													23	186					3.10358e-05	3.90007e-05	1	0	A	9520158	A	A	9520158	3	1	101	1	0	0	0	0	1	0	0	0	11459	507	18	4	52	4	PAK7	20	9520158	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08		9520158	53505362	81	19350											
TM9SF4	9777	broad.mit.edu	37	chr20	30723921	30723921	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acccagctaccttatgaataCtattcactgcccttctgcca	10	12	4	15	0	2	1	1	1	1	0	2	1	2	1	4	0	5	1	4	0	5	6			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr20:30723921C>G	uc002wxj.2	+	3	409	c.174C>G	c.(172-174)TAC>TAG	p.Y58*	TM9SF4_uc010ztr.1_5'UTR|TM9SF4_uc010zts.1_5'UTR|TM9SF4_uc002wxk.2_Nonsense_Mutation_p.Y41*	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	58						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTTATGAATACTATTCACTGC	0.512													13	68					0	0	0	0	G	30723921	G	G	30723921	4	3	101	1	0	0	0	0	0	1	0	0	16046	576	20	4	184	4	TM9SF4	20	30723921	Nonsense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	21203763	30723921	32301599	82	19351											
GGT7	2686	broad.mit.edu	37	chr20	33451191	33451191	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaggtgagacaggccgtgacGatgaccgtgagcccatcctg	10	6	14	11	3	0	4	0	4	0	1	1	6	1	4	4	2	1	0	4	2	1	0			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr20:33451191G>A	uc002xay.2	-	2	373	c.330C>T	c.(328-330)ATC>ATT	p.I110I	GGT7_uc002xaz.1_Silent_p.I127I|GGT7_uc002xba.1_Silent_p.I110I	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	110	Helical; Signal-anchor for type II membrane protein; (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						AGGCCGTGACGATGACCGTGA	0.677													9	72					0	0	0	0	A	33451191	A	A	33451191	2	1	101	1	0	0	0	0	0	0	0	1	6401	1048	37	1		1	GGT7	20	33451191	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	2727270	33451191	29574329	83	19352											
RBL1	5933	broad.mit.edu	37	chr20	35695243	35695243	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaatgatgcagggtggctCttcagaagccgtaaagtcag	12	8	13	8	1	3	2	2	1	1	1	3	2	3	2	1	2	3	4	1	2	4	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr20:35695243C>G	uc002xgi.2	-	6	809	c.730G>C	c.(730-732)GAG>CAG	p.E244Q	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.E244Q|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	244					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				CAGGGTGGCTCTTCAGAAGCC	0.388													6	131					0	0	0	0	G	35695243	G	G	35695243	3	3	101	1	0	0	0	0	1	0	0	0	13174	922	32	2	2553	2	RBL1	20	35695243	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	2244052	35695243	27330277	84	19353											
PFKL	5211	broad.mit.edu	37	chr21	45744411	45744411	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagtctgcctcggggaccaAgcgccgtgtgttcatcgtgg	6	9	14	12	4	2	0	1	0	1	0	4	1	2	1	3	3	2	1	3	3	1	1			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr21:45744411A>G	uc002zel.2	+	17	1747	c.1688A>G	c.(1687-1689)AAG>AGG	p.K563R	PFKL_uc002zek.2_Missense_Mutation_p.K610R|PFKL_uc002zem.2_Missense_Mutation_p.K150R|PFKL_uc002zen.2_Missense_Mutation_p.K150R	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	563					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		TCGGGGACCAAGCGCCGTGTG	0.662													13	51					0	0	0	0	G	45744411	G	G	45744411	3	3	101	1	0	0	0	0	1	0	0	0	11819	72	3	5	1754	5	PFKL	21	45744411	Missense_Mutation	SNP	A	TCGA-CQ-6219-01A-11D-1912-08		45744411	2385484	85	19354											
PCNT	5116	broad.mit.edu	37	chr21	47836599	47836599	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agccctgagcctgtgcagtgCcgacacatccctgggggaca	8	6	13	14	1	0	1	0	1	0	0	1	3	1	2	4	2	4	1	4	2	0	0			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr21:47836599C>T	uc002zji.3	+	30	6874	c.6767C>T	c.(6766-6768)GCC>GTC	p.A2256V	PCNT_uc002zjj.2_Missense_Mutation_p.A2138V	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2256					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CTGTGCAGTGCCGACACATCC	0.692													5	53					0	0	0	0	T	47836599	T	T	47836599	3	4	101	1	0	0	0	0	1	0	0	0	11644	739	26	4	6885	4	PCNT	21	47836599	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	2092188	47836599	293296	86	19355											
THAP7	80764	broad.mit.edu	37	chr22	21354371	21354371	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catcaagggctgcctcggctCgccgcttccagagtaaggcg	7	7	13	14	4	1	1	1	0	0	1	4	1	2	1	3	3	1	4	3	3	2	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chr22:21354371C>T	uc002ztr.1	-	5	758	c.728G>A	c.(727-729)CGA>CAA	p.R243Q	THAP7_uc002zts.1_Missense_Mutation_p.R243Q|FLJ39582_uc002ztt.1_5'Flank|FLJ39582_uc002ztu.1_5'Flank|FLJ39582_uc002ztv.2_5'Flank	NM_001008695	NP_001008695	Q9BT49	THAP7_HUMAN	THAP domain containing 7 isoform 2	243					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding				0	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGCCTCGGCTCGCCGCTTCCA	0.662													4	31					0	0	0	0	T	21354371	T	T	21354371	3	4	101	1	0	0	0	0	1	0	0	0	15915	884	31	1	205	1	THAP7	22	21354371	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08		21354371	29950195	87	19356											
DMD	1756	broad.mit.edu	37	chrX	31792157	31792157	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttataacttgatcaagcaGagaaagccagtcggtaagtt	14	12	9	6	1	1	2	1	1	0	1	2	3	1	2	1	1	3	3	1	1	5	6			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chrX:31792157G>A	uc004dda.1	-	51	7706	c.7462C>T	c.(7462-7464)CTG>TTG	p.L2488L	DMD_uc004dcr.1_Silent_p.L28L|DMD_uc004dcs.1_Silent_p.L28L|DMD_uc004dct.1_Silent_p.L28L|DMD_uc004dcu.1_Silent_p.L28L|DMD_uc004dcv.1_Silent_p.L28L|DMD_uc004dcw.2_Silent_p.L1144L|DMD_uc004dcx.2_Silent_p.L1147L|DMD_uc004dcz.2_Silent_p.L2365L|DMD_uc004dcy.1_Silent_p.L2484L|DMD_uc004ddb.1_Silent_p.L2480L|DMD_uc004ddd.1_Silent_p.L28L	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2488	Spectrin 17.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGATCAAGCAGAGAAAGCCAG	0.438													10	81					0	0	0	0	A	31792157	A	A	31792157	2	1	101	1	0	0	0	0	0	0	0	1	4602	933	33	2		2	DMD	23	31792157	Silent	SNP	G	TCGA-CQ-6219-01A-11D-1912-08		31792157	123478403	88	19357											
WNK3	65267	broad.mit.edu	37	chrX	54324751	54324751	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatgaatttgagcaatcatCttcttctgctaactccaccc	10	13	6	12	0	4	2	1	2	3	0	5	3	5	3	2	1	3	2	2	1	3	4			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chrX:54324751C>G	uc004dtd.1	-	7	1694	c.1255G>C	c.(1255-1257)GAT>CAT	p.D419H	WNK3_uc004dtc.1_Missense_Mutation_p.D419H	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	419					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GAGCAATCATCTTCTTCTGCT	0.363													6	48					0	0	0	0	G	54324751	G	G	54324751	3	3	101	1	0	0	0	0	1	0	0	0	17447	913	32	2	4219	2	WNK3	23	54324751	Missense_Mutation	SNP	C	TCGA-CQ-6219-01A-11D-1912-08	22532594	54324751	100945809	89	19358											
AVPR2	554	broad.mit.edu	37	chrX	153172115	153172115	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggggacgcaccccacccaGcctgggtccccaagatgagt	8	4	12	17	2	0	2	0	1	0	1	1	3	1	3	7	3	1	1	7	3	1	0			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chrX:153172115G>C	uc004fjh.3	+	3	1120	c.1049G>C	c.(1048-1050)AGC>ACC	p.S350T	AVPR2_uc004fjg.3_Missense_Mutation_p.S139T|AVPR2_uc004fji.2_3'UTR	NM_000054	NP_000045	P30518	V2R_HUMAN	arginine vasopressin receptor 2 isoform 1	350	Cytoplasmic (Potential).				activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	ACCCCACCCAGCCTGGGTCCC	0.607													5	86					0	0	0	0	C	153172115	C	C	153172115	3	2	101	1	0	0	0	0	1	0	0	0	1235	971	34	4	1079	4	AVPR2	23	153172115	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	98847364	153172115	2098445	90	19359											
HCFC1	3054	broad.mit.edu	37	chrX	153218117	153218117	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatgagggtggtggtgccaGcttgggcctcggccattagc	5	9	16	11	1	0	1	0	1	0	0	1	1	0	1	4	5	3	1	4	5	1	2			TCGA-CQ-6219-01A-11D-1912-08	TCGA-CQ-6219-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c6263b94-0ffe-40e7-9184-deb427c67802	266b5bc3-c9cf-433b-9ddd-eb2da0dcabfd	g.chrX:153218117G>A	uc004fjp.2	-	19	5318	c.4790C>T	c.(4789-4791)GCT>GTT	p.A1597V		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1597					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGTGGTGCCAGCTTGGGCCTC	0.652													4	61					0	0	0	0	A	153218117	A	A	153218117	3	1	101	1	0	0	0	0	1	0	0	0	7030	971	34	4	1349	4	HCFC1	23	153218117	Missense_Mutation	SNP	G	TCGA-CQ-6219-01A-11D-1912-08	46002	153218117	2052443	91	19360											
RERE	473	broad.mit.edu	37	chr1	8421141	8421142	+	Frame_Shift_Ins	INS	-	G	G																															atgcggtgagggcggccgctINSgggggtgcaaggccggtgcc																										TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr1:8421141_8421142insG	uc001ape.2	-	19	3235_3236	c.2425_2426insC	c.(2425-2427)CAGfs	p.Q809fs	RERE_uc001apf.2_Frame_Shift_Ins_p.Q809fs|RERE_uc010nzx.1_Frame_Shift_Ins_p.Q541fs|RERE_uc001apd.2_Frame_Shift_Ins_p.Q255fs	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	809	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		gggCGGCCGCTGGGGGTGCAAG	0.574													---	---	---								G	8421142	G	G	8421141	7	5	102	1	0	1	1	0	0	0	0	0	13296	1580	55	0	2298	0	RERE	1	8421141	Frame_Shift_Ins	INS	-	TCGA-CQ-6220-01A-11D-1912-08		8421141	240829480	1	19361											
CGN	57530	broad.mit.edu	37	chr1	151491340	151491340	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagggatttcctgccccctcGcagagcagcacatctgatga	10	8	10	13	1	1	3	0	2	1	1	3	4	2	4	3	1	3	3	3	1	1	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr1:151491340G>A	uc009wmw.2	+	2	489	c.345G>A	c.(343-345)TCG>TCA	p.S115S		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	109	Interacts with ZO-2.|Head.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTGCCCCCTCGCAGAGCAGCA	0.602													6	16					0	0	0	0	A	151491340	A	A	151491340	2	1	102	1	0	0	0	0	0	0	0	1	3318	1074	38	1		1	CGN	1	151491340	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	143070199	151491340	97759281	2	19362											
MEF2D	4209	broad.mit.edu	37	chr1	156450662	156450662	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcccgtcgagctcctcgctGgcgcgtcggtacttgtcctc	3	10	12	16	6	0	0	0	0	0	0	6	1	2	0	3	2	3	3	3	2	1	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr1:156450662G>T	uc001fpc.2	-	4	750	c.360C>A	c.(358-360)GCC>GCA	p.A120A	MEF2D_uc001fpb.2_Silent_p.A120A|MEF2D_uc001fpd.2_Silent_p.A120A|MEF2D_uc001fpe.1_Silent_p.A120A|MEF2D_uc009wsa.2_RNA	NM_005920	NP_005911	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	120					apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCTCCTCGCTGGCGCGTCGGT	0.692											OREG0013874	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	55					2.75727e-19	3.56297e-19	1	0	T	156450662	T	T	156450662	2	4	102	1	0	0	0	0	0	0	0	1	9511	1335	47	4		4	MEF2D	1	156450662	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	4959322	156450662	92799959	3	19363											
SPTA1	6708	broad.mit.edu	37	chr1	158607998	158607998	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcccgctggagagcaaatCttcagccaatgtattcaggt	11	10	10	10	1	3	1	2	0	1	1	4	2	4	1	2	2	2	3	2	2	3	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr1:158607998C>A	uc001fst.1	-	36	5213	c.5014G>T	c.(5014-5016)GAT>TAT	p.D1672Y		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1672	Spectrin 16.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GAGAGCAAATCTTCAGCCAAT	0.418													15	24					3.41278e-10	4.35349e-10	1	0	A	158607998	A	A	158607998	3	1	102	1	0	0	0	0	1	0	0	0	15182	913	32	2	2313	2	SPTA1	1	158607998	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	2157336	158607998	90642623	4	19364											
ITLN1	55600	broad.mit.edu	37	chr1	160853237	160853237	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaatgcactaggacattcGtctttgatttccttgcagct	9	14	7	11	1	1	1	0	1	1	0	3	2	2	2	2	1	3	3	2	1	2	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr1:160853237G>A	uc001fxc.2	-	3	254	c.138C>T	c.(136-138)GAC>GAT	p.D46D		NM_017625	NP_060095	Q8WWA0	ITLN1_HUMAN	intelectin precursor	46	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)	7	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TAGGACATTCGTCTTTGATTT	0.423													21	35					0	0	0	0	A	160853237	A	A	160853237	2	1	102	1	0	0	0	0	0	0	0	1	7949	1136	40	1		1	ITLN1	1	160853237	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	2245239	160853237	88397384	5	19365											
PRRX1	5396	broad.mit.edu	37	chr1	170695426	170695426	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccatgctagccaataaaaaCgcttccctcctcaaatccta	13	9	4	15	1	1	0	1	0	0	0	4	0	4	0	5	0	3	2	5	0	7	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr1:170695426C>T	uc001ghf.2	+	3	530	c.483C>T	c.(481-483)AAC>AAT	p.N161N	PRRX1_uc001ghe.2_Silent_p.N161N	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	161						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCAATAAAAACGCTTCCCTCC	0.537													16	27					0	0	0	0	T	170695426	T	T	170695426	2	4	102	1	0	0	0	0	0	0	0	1	12674	535	19	1		1	PRRX1	1	170695426	Silent	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	9842189	170695426	78555195	6	19366											
KIF21B	23046	broad.mit.edu	37	chr1	200959778	200959778	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacgatgtcaatgatccgtcGctccagggactgccacttga	9	9	11	12	3	1	2	1	2	0	0	4	5	3	3	3	1	1	1	3	1	1	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr1:200959778G>A	uc001gvs.1	-	19	3078	c.2761C>T	c.(2761-2763)CGA>TGA	p.R921*	KIF21B_uc001gvr.1_Nonsense_Mutation_p.R921*|KIF21B_uc009wzl.1_Nonsense_Mutation_p.R921*|KIF21B_uc010ppn.1_Nonsense_Mutation_p.R921*	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	921					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						ATGATCCGTCGCTCCAGGGAC	0.562													6	41					0	0	0	0	A	200959778	A	A	200959778	4	1	102	1	0	0	0	0	0	1	0	0	8328	1095	38	1	2177	1	KIF21B	1	200959778	Nonsense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	30264352	200959778	48290843	7	19367											
ARV1	64801	broad.mit.edu	37	chr1	231131561	231131562	+	Missense_Mutation	DNP	GA	AC	AC																															ctgtgggtagaacggcccatGacggcaaaaaaaaagcccaa																										TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr1:231131561_231131562GA>AC	uc009xfl.1	+	4	533_534	c.504_505GA>AC	c.(502-507)ATGACG>ATACCG	p.168_169MT>IP	ARV1_uc001huh.2_Missense_Mutation_p.168_169MT>IP	NM_022786	NP_073623	Q9H2C2	ARV1_HUMAN	ARV1 homolog	168_169					sphingolipid metabolic process	integral to membrane				breast(2)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		AACGGCCCATGACGGCAAAAAA	0.381													8	37					0	0	0	0	AC	231131562	AC	AC	231131561	3	1	102	1	0	0	0	0	1	0	0	0	1004	1290	45	2	518	2	ARV1	1	231131561	Missense_Mutation	DNP	GA	TCGA-CQ-6220-01A-11D-1912-08	30171783	231131561	18119060	8	19368											
ALK	238	broad.mit.edu	37	chr2	29474101	29474101	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggtggggccatggggccCgctggccccacatgtggtga	4	7	18	12	1	0	1	0	1	0	0	0	1	0	1	4	7	0	1	4	7	0	0			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:29474101C>T	uc002rmy.2	-	12	2981	c.2074G>A	c.(2074-2076)GGG>AGG	p.G692R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	692	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCATGGGGCCCGCTGGCCCCA	0.647			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				4	24					0	0	0	0	T	29474101	T	T	29474101	3	4	102	1	0	0	0	0	1	0	0	0	525	652	23	1	2860	1	ALK	2	29474101	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08		29474101	213725272	9	19369											
RNF103	7844	broad.mit.edu	37	chr2	86832193	86832193	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatatatgccaatatctgtCatataactcttgttgtccca	11	17	4	9	0	3	0	1	0	2	0	4	0	4	0	2	0	2	1	2	0	7	8			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:86832193C>G	uc002srn.2	-	4	1800	c.831G>C	c.(829-831)ATG>ATC	p.M277I	VPS24_uc010ytl.1_Intron|RNF103_uc002srm.2_Missense_Mutation_p.M138I|uc002sro.2_Intron	NM_005667	NP_005658	O00237	RN103_HUMAN	ring finger protein 103	277					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)	1						CAATATCTGTCATATAACTCT	0.363													5	30					0	0	0	0	G	86832193	G	G	86832193	3	3	102	1	0	0	0	0	1	0	0	0	13488	826	29	2	1230	2	RNF103	2	86832193	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	57358092	86832193	156367180	10	19370											
KYNU	8942	broad.mit.edu	37	chr2	143643039	143643039	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggtggctctccacctagatGaggaagataagctgaggcac	11	7	14	9	0	1	4	0	2	1	2	2	5	1	5	2	4	1	3	2	4	3	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:143643039G>A	uc002tvl.2	+	2	233	c.103G>A	c.(103-105)GAG>AAG	p.E35K	KYNU_uc002tvk.2_Missense_Mutation_p.E35K|KYNU_uc010fnm.2_Missense_Mutation_p.E35K	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	35					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	CCACCTAGATGAGGAAGATAA	0.488													12	35					0	0	0	0	A	143643039	A	A	143643039	3	1	102	1	0	0	0	0	1	0	0	0	8627	1291	45	2	105	2	KYNU	2	143643039	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	56810846	143643039	99556334	11	19371											
NEB	4703	broad.mit.edu	37	chr2	152512971	152512971	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttttcataattgtacttgTatttatactgtgaagaaaat	13	19	5	4	0	1	2	1	1	0	1	1	2	1	2	0	0	2	2	0	0	8	10			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:152512971T>C	uc010fnx.2	-	49	6382	c.6191A>G	c.(6190-6192)TAC>TGC	p.Y2064C		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2064	Nebulin 54.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATTGTACTTGTATTTATACTG	0.328													27	60					0	0	0	0	C	152512971	C	C	152512971	3	2	102	1	0	0	0	0	1	0	0	0	10356	1638	57	5	20031	5	NEB	2	152512971	Missense_Mutation	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	8869932	152512971	90686402	12	19372											
LRP2	4036	broad.mit.edu	37	chr2	170009349	170009349	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tattccatctggctgcattaCgtatttcagtttcaggtcaa	9	16	7	9	1	4	0	3	0	1	0	5	0	5	0	1	2	2	4	1	2	4	6	rs150382715	byFrequency	TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:170009349C>A	uc002ues.2	-	67	12634	c.12421G>T	c.(12421-12423)GTA>TTA	p.V4141L		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4141	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGCTGCATTACGTATTTCAGT	0.468													62	185					1.41401e-22	1.83913e-22	1	0	A	170009349	A	A	170009349	3	1	102	1	0	0	0	0	1	0	0	0	9006	536	19	3	1598	3	LRP2	2	170009349	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	17496378	170009349	73190024	13	19373											
TTN	7273	broad.mit.edu	37	chr2	179426874	179426874	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtctgaccatcttttctccaGttcacagtagcttgaggtct	7	15	8	11	0	5	2	1	2	4	0	6	2	5	2	2	1	1	3	2	1	1	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:179426874G>T	uc010zfg.1	-	275	76505	c.76281C>A	c.(76279-76281)AAC>AAA	p.N25427K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N19122K|TTN_uc010zfi.1_Missense_Mutation_p.N19055K|TTN_uc010zfj.1_Missense_Mutation_p.N18930K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26354							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTTCTCCAGTTCACAGTAG	0.383													8	15					5.18039e-06	6.40309e-06	1	0	T	179426874	T	T	179426874	3	4	102	1	0	0	0	0	1	0	0	0	16803	1020	36	4	24142	4	TTN	2	179426874	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	9417525	179426874	63772499	14	19374											
CASP8	841	broad.mit.edu	37	chr2	202131421	202131421	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgctcttccgaattaataGactggatttgctgattacct	9	15	8	9	1	1	2	0	1	1	1	2	4	2	3	2	1	3	3	2	1	4	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:202131421G>C	uc002uxr.1	+	3	421	c.212G>C	c.(211-213)AGA>ACA	p.R71T	CASP8_uc010ftc.1_Missense_Mutation_p.R71T|CASP8_uc002uxo.1_Missense_Mutation_p.R71T|CASP8_uc002uxp.1_Missense_Mutation_p.R71T|CASP8_uc002uxq.1_Missense_Mutation_p.R71T|CASP8_uc002uxs.1_Missense_Mutation_p.R71T|CASP8_uc002uxt.1_Missense_Mutation_p.R130T|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.R71T|CASP8_uc002uxw.1_Missense_Mutation_p.R71T|CASP8_uc002uxy.1_Missense_Mutation_p.R71T|CASP8_uc002uxx.1_Missense_Mutation_p.R71T|CASP8_uc010ftf.2_Missense_Mutation_p.R71T	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	71	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CGAATTAATAGACTGGATTTG	0.458										HNSCC(4;0.00038)			18	37					0	0	0	0	C	202131421	C	C	202131421	3	2	102	1	0	0	0	0	1	0	0	0	2689	942	33	2	395	2	CASP8	2	202131421	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	22704547	202131421	41067952	15	19375											
ABCB6	10058	broad.mit.edu	37	chr2	220077120	220077120	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caaccctacctgtgaaatgtCctgcccatctattcggatgc	9	11	7	14	1	1	1	0	1	1	0	3	2	2	2	4	1	4	0	4	1	4	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:220077120C>G	uc002vkc.1	-	14	2234	c.1957G>C	c.(1957-1959)GAC>CAC	p.D653H	ABCB6_uc010fwe.1_Missense_Mutation_p.D607H	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	653	ABC transporter.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGTGAAATGTCCTGCCCATCT	0.552													8	54					0	0	0	0	G	220077120	G	G	220077120	3	3	102	1	0	0	0	0	1	0	0	0	45	855	30	2	595	2	ABCB6	2	220077120	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	17945699	220077120	23122253	16	19376											
EPHA4	2043	broad.mit.edu	37	chr2	222347096	222347096	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggttggtggtcacagtgaCagaaactgattggtctgggt	8	13	15	5	0	2	3	1	2	1	1	2	3	2	3	0	5	1	1	0	5	1	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:222347096C>G	uc002vmq.2	-	5	1336	c.1294G>C	c.(1294-1296)GTC>CTC	p.V432L	EPHA4_uc002vmr.2_Missense_Mutation_p.V432L|EPHA4_uc010zlm.1_Missense_Mutation_p.V373L|EPHA4_uc010zln.1_Missense_Mutation_p.V432L	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	432	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GTCACAGTGACAGAAACTGAT	0.378													14	140					0	0	0	0	G	222347096	G	G	222347096	3	3	102	1	0	0	0	0	1	0	0	0	5193	478	17	4	1718	4	EPHA4	2	222347096	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	2269976	222347096	20852277	17	19377											
UGT1A3	54659	broad.mit.edu	37	chr2	234637859	234637859	+	Silent	SNP	A	G	G																															cagccctgggctgagagtggAaaggtgttggtggtgcccat																										TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:234637859A>G	uc002vuy.2	+	1	87	c.87A>G	c.(85-87)GGA>GGG	p.G29G	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Silent_p.G29G	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	29					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTGAGAGTGGAAAGGTGTTGG	0.632													7	50					0	0	0	0	G	234637859	G	G	234637859	2	3	102	1	0	0	0	0	0	0	0	1	17014	233	9	5		5	UGT1A3	2	234637859	Silent	SNP	A	TCGA-CQ-6220-01A-11D-1912-08	12290763	234637859	8561514	18	19378	39	2									
UGT1A3	54659	broad.mit.edu	37	chr2	234637866	234637866	+	Silent	SNP	T	C	C																															gggctgagagtggaaaggtgTtggtggtgcccattgatggc																										TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr2:234637866T>C	uc002vuy.2	+	1	94	c.94T>C	c.(94-96)TTG>CTG	p.L32L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Silent_p.L32L	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	32					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TGGAAAGGTGTTGGTGGTGCC	0.637													6	55					0	0	0	0	C	234637866	C	C	234637866	2	2	102	1	0	0	0	0	0	0	0	1	17014	1722	60	5		5	UGT1A3	2	234637866	Silent	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	7	234637866	8561507	19	19379	39	2									
GRM7	2917	broad.mit.edu	37	chr3	7188209	7188209	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctatgacttcttctctcGcgtggtgccacccgattcct	4	13	9	15	4	2	1	0	1	2	0	5	2	3	1	3	1	1	1	3	1	1	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr3:7188209G>A	uc003bqm.2	+	2	864	c.590G>A	c.(589-591)CGC>CAC	p.R197H	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.R197H|GRM7_uc003bql.2_Missense_Mutation_p.R197H	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	197	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TTCTTCTCTCGCGTGGTGCCA	0.522													16	57					0	0	0	0	A	7188209	A	A	7188209	3	1	102	1	0	0	0	0	1	0	0	0	6841	1087	38	1	596	1	GRM7	3	7188209	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		7188209	190834221	20	19380											
TRANK1	9881	broad.mit.edu	37	chr3	36872599	36872599	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acttgctgcctctggtggtgTtctagatggatatgctgctc	5	15	12	9	0	2	1	0	0	2	1	3	2	2	2	1	3	4	4	1	3	2	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr3:36872599T>C	uc003cgj.2	-	12	6995	c.6693A>G	c.(6691-6693)GAA>GAG	p.E2231E		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2781					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TCTGGTGGTGTTCTAGATGGA	0.552													38	65					0	0	0	0	C	36872599	C	C	36872599	2	2	102	1	0	0	0	0	0	0	0	1	16521	1722	60	5		5	TRANK1	3	36872599	Silent	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	29684390	36872599	161149831	21	19381											
COL6A6	131873	broad.mit.edu	37	chr3	130285812	130285812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgggaatacaaacacaggcGcagcactgaatttcacactg	14	7	10	10	1	1	1	1	1	0	0	1	2	1	2	0	2	3	2	0	2	4	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr3:130285812G>A	uc010htl.2	+	4	1580	c.1549G>A	c.(1549-1551)GCA>ACA	p.A517T		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	517	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AAACACAGGCGCAGCACTGAA	0.448													27	93					0	0	0	0	A	130285812	A	A	130285812	3	1	102	1	0	0	0	0	1	0	0	0	3718	1087	38	1	1563	1	COL6A6	3	130285812	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	93413213	130285812	67736618	22	19382											
GC	2638	broad.mit.edu	37	chr4	72623827	72623827	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgttagtaatatcttcagCtagtggcaaaacatcctcca	13	12	7	9	0	2	0	1	0	1	0	4	1	4	0	2	1	2	4	2	1	6	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr4:72623827C>T	uc003hge.2	-	7	916	c.763G>A	c.(763-765)GCT>ACT	p.A255T	GC_uc003hgd.2_Missense_Mutation_p.A133T|GC_uc010iie.2_Missense_Mutation_p.A255T|GC_uc010iif.2_Missense_Mutation_p.A274T	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	255	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	ATATCTTCAGCTAGTGGCAAA	0.373													13	62					0	0	0	0	T	72623827	T	T	72623827	3	4	102	1	0	0	0	0	1	0	0	0	6317	797	28	4	685	4	GC	4	72623827	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08		72623827	118530449	23	19383											
DCHS2	54798	broad.mit.edu	37	chr4	155158175	155158175	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgaattcaggggcataattGttcatatcttctattcctat	10	17	7	7	0	4	1	2	1	2	0	5	1	5	1	1	2	0	2	1	2	5	9	rs141912971		TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr4:155158175G>A	uc003inw.2	-	25	6264	c.6264C>T	c.(6262-6264)AAC>AAT	p.N2088N		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2088	Cadherin 18.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GGGCATAATTGTTCATATCTT	0.398													18	67					0	0	0	0	A	155158175	A	A	155158175	2	1	102	1	0	0	0	0	0	0	0	1	4305	1368	48	4		4	DCHS2	4	155158175	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	82534348	155158175	35996101	24	19384											
CTSO	1519	broad.mit.edu	37	chr4	156860670	156860670	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccactgcccccaccacgctGaaggcccagcatcctccaca	9	5	6	21	1	0	1	0	1	0	0	3	1	3	1	7	1	2	2	7	1	1	0			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr4:156860670G>A	uc003ipg.2	-	4	454	c.405C>T	c.(403-405)TTC>TTT	p.F135F		NM_001334	NP_001325	P43234	CATO_HUMAN	cathepsin O preproprotein	135					proteolysis	lysosome	cysteine-type endopeptidase activity				0	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		CCACCACGCTGAAGGCCCAGC	0.433													15	87					0	0	0	0	A	156860670	A	A	156860670	2	1	102	1	0	0	0	0	0	0	0	1	4057	1281	45	2		2	CTSO	4	156860670	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	1702495	156860670	34293606	25	19385											
RICTOR	253260	broad.mit.edu	37	chr5	38950723	38950723	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttatcctttatgggtccaGatcggtcataaaatgttggc	9	16	9	7	1	1	1	1	0	0	1	4	1	3	1	2	3	0	1	2	3	4	6			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr5:38950723G>C	uc003jlp.2	-	31	3251	c.3227C>G	c.(3226-3228)TCT>TGT	p.S1076C	RICTOR_uc003jlo.2_Missense_Mutation_p.S1076C|RICTOR_uc010ivf.2_Missense_Mutation_p.S791C	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1076					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TATGGGTCCAGATCGGTCATA	0.368													16	93					0	0	0	0	C	38950723	C	C	38950723	3	2	102	1	0	0	0	0	1	0	0	0	13423	942	33	2	1931	2	RICTOR	5	38950723	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		38950723	141964537	26	19386											
ITGA2	3673	broad.mit.edu	37	chr5	52366018	52366018	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttatttaaagaaaacaaTgaaaggtgcctgcagaagaa	18	8	11	4	0	0	4	0	1	0	3	0	4	0	4	1	2	3	2	1	2	9	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr5:52366018T>C	uc003joy.2	+	17	2306	c.2163T>C	c.(2161-2163)AAT>AAC	p.N721N	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Silent_p.N645N|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	721	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AAGAAAACAATGAAAGGTGCC	0.383													3	83					0	0	0	0	C	52366018	C	C	52366018	2	2	102	1	0	0	0	0	0	0	0	1	7914	1461	51	5		5	ITGA2	5	52366018	Silent	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	13415295	52366018	128549242	27	19387											
HTR1A	3350	broad.mit.edu	37	chr5	63257091	63257091	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgagatgagcgcagcggcGcgccggggcgtcctcttgtt	5	7	17	12	7	1	2	0	1	1	1	2	3	2	2	2	3	3	2	2	3	0	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr5:63257091G>A	uc011cqt.1	-	1	456	c.456C>T	c.(454-456)CGC>CGT	p.R152R		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	152	Cytoplasmic (By similarity).			RAA -> PR (in Ref. 1; AAA36440/CAA31908).	behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GCGCAGCGGCGCGCCGGGGCG	0.652													22	84					0	0	0	0	A	63257091	A	A	63257091	2	1	102	1	0	0	0	0	0	0	0	1	7475	1074	38	1		1	HTR1A	5	63257091	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	10891073	63257091	117658169	28	19388											
THBS4	7060	broad.mit.edu	37	chr5	79375854	79375854	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggctggaaggacaaggtgTcctaccgctggttcctacag	8	9	14	10	1	0	0	0	0	0	0	2	2	2	2	3	5	2	3	3	5	4	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr5:79375854T>C	uc003kgh.2	+	21	2961	c.2638T>C	c.(2638-2640)TCC>CCC	p.S880P	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	880	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GGACAAGGTGTCCTACCGCTG	0.587													4	26					0	0	0	0	C	79375854	C	C	79375854	3	2	102	1	0	0	0	0	1	0	0	0	15922	1667	58	5	2716	5	THBS4	5	79375854	Missense_Mutation	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	16118763	79375854	101539406	29	19389											
PCDHGC4	56098	broad.mit.edu	37	chr5	140865546	140865546	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagctcaatgcctcagaccCggacctgggtcccagtggta	8	7	11	15	1	2	1	2	0	0	1	3	2	3	2	5	3	2	2	5	3	2	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr5:140865546C>T	uc003lky.1	+	1	806	c.806C>T	c.(805-807)CCG>CTG	p.P269L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Missense_Mutation_p.P269L	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	269	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCTCAGACCCGGACCTGGGT	0.542													9	80					0	0	0	0	T	140865546	T	T	140865546	3	4	102	1	0	0	0	0	1	0	0	0	11624	652	23	1	808	1	PCDHGC4	5	140865546	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	61489692	140865546	40049714	30	19390											
CAMK2A	815	broad.mit.edu	37	chr5	149636340	149636340	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacactcacctggcatccgcCtcactgtaatactcccgggc	8	8	8	17	2	2	0	2	0	0	0	4	1	4	0	4	2	1	2	4	2	2	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr5:149636340C>T	uc003lru.2	-	5	542	c.327G>A	c.(325-327)GAG>GAA	p.E109E	CAMK2A_uc003lrt.2_Silent_p.E109E|CAMK2A_uc010jhe.2_Silent_p.E89E|CAMK2A_uc010jhf.1_5'Flank	NM_171825	NP_741960	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II	109	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGCATCCGCCTCACTGTAAT	0.602													16	34					0	0	0	0	T	149636340	T	T	149636340	2	4	102	1	0	0	0	0	0	0	0	1	2611	680	24	4		4	CAMK2A	5	149636340	Silent	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	8770794	149636340	31278920	31	19391											
GABRA1	2554	broad.mit.edu	37	chr5	161277887	161277887	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgagcacactgactggaaGaaggtggggacactttttta	11	11	12	7	0	1	3	0	2	1	1	1	5	1	5	0	4	1	1	0	4	3	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr5:161277887G>T	uc010jiw.2	+	3	539	c.71G>T	c.(70-72)AGA>ATA	p.R24I	GABRA1_uc010jix.2_Missense_Mutation_p.R24I|GABRA1_uc010jiy.2_Missense_Mutation_p.R24I|GABRA1_uc003lyx.3_Missense_Mutation_p.R24I|GABRA1_uc010jiz.2_Missense_Mutation_p.R24I|GABRA1_uc010jja.2_Missense_Mutation_p.R24I|GABRA1_uc010jjb.2_Missense_Mutation_p.R24I	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	24					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CTGACTGGAAGAAGGTGGGGA	0.413													14	72					1.37285e-15	1.76257e-15	1	0	T	161277887	T	T	161277887	3	4	102	1	0	0	0	0	1	0	0	0	6194	942	33	2	73	2	GABRA1	5	161277887	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	11641547	161277887	19637373	32	19392											
HIST1H3I	8354	broad.mit.edu	37	chr6	27839968	27839968	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agggccacggtgccggggcgGtagcggtggggcttcttgac	4	7	20	10	4	1	1	0	1	1	0	1	1	1	1	2	8	2	2	2	8	1	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr6:27839968G>A	uc003njy.2	-	1	132	c.126C>T	c.(124-126)TAC>TAT	p.Y42Y		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	42					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						TGCCGGGGCGGTAGCGGTGGG	0.682													35	78					0	0	0	0	A	27839968	A	A	27839968	2	1	102	1	0	0	0	0	0	0	0	1	7202	1256	44	4		4	HIST1H3I	6	27839968	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		27839968	143275099	33	19393											
OR2H1	26716	broad.mit.edu	37	chr6	29430027	29430027	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatagtccagacaccatccAccctccacttgcccttctgt	8	10	5	18	1	1	1	0	0	1	1	4	2	4	1	6	0	1	0	6	0	1	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr6:29430027A>G	uc003nmi.2	+	3	924	c.481A>G	c.(481-483)ACC>GCC	p.T161A	OR2H1_uc003nmj.1_Missense_Mutation_p.T161A|OR2H1_uc010jri.1_Missense_Mutation_p.T83A	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GACACCATCCACCCTCCACTT	0.537													26	208					0	0	0	0	G	29430027	G	G	29430027	3	3	102	1	0	0	0	0	1	0	0	0	11055	159	6	5	483	5	OR2H1	6	29430027	Missense_Mutation	SNP	A	TCGA-CQ-6220-01A-11D-1912-08	1590059	29430027	141685040	34	19394											
GABRR2	2570	broad.mit.edu	37	chr6	89978925	89978925	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctctcatccttccagtaaTgccgcaggtacagggtcata	9	10	9	13	1	2	0	2	0	1	0	5	0	4	0	4	2	2	3	4	2	3	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr6:89978925T>C	uc003pnb.2	-	4	400	c.392A>G	c.(391-393)CAT>CGT	p.H131R	GABRR2_uc011dzx.1_Missense_Mutation_p.H7R	NM_002043	NP_002034	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 2	131	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		CTTCCAGTAATGCCGCAGGTA	0.522													39	113					0	0	0	0	C	89978925	C	C	89978925	3	2	102	1	0	0	0	0	1	0	0	0	6211	1464	51	5	1104	5	GABRR2	6	89978925	Missense_Mutation	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	60548898	89978925	81136142	35	19395											
FAM26D	221301	broad.mit.edu	37	chr6	116879126	116879126	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaatgagagagaactctttGaacaagcagcagagcagcac	17	5	11	8	0	1	5	0	2	1	4	1	7	1	5	0	0	6	4	0	0	4	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr6:116879126G>C	uc003pxa.2	+	4	567	c.268G>C	c.(268-270)GAA>CAA	p.E90Q	FAM26D_uc003pwz.2_Missense_Mutation_p.E47Q|FAM26D_uc010ked.2_Missense_Mutation_p.E89Q	NM_153036	NP_694581	Q5JW98	FA26D_HUMAN	hypothetical protein LOC221301	233						integral to membrane					0		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0458)|OV - Ovarian serous cystadenocarcinoma(136;0.0694)|Epithelial(106;0.222)		AGAACTCTTTGAACAAGCAGC	0.517													22	86					0	0	0	0	C	116879126	C	C	116879126	3	2	102	1	0	0	0	0	1	0	0	0	5581	1291	45	2	141	2	FAM26D	6	116879126	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	26900201	116879126	54235941	36	19396											
CENPW	387103	broad.mit.edu	37	chr6	126661543	126661543	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggagaaaagtggtgacttaTtggtgagattccatcccttc	10	13	11	7	0	0	3	0	2	0	2	3	5	2	3	2	3	0	0	2	3	3	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr6:126661543T>C	uc003qao.2	+	1	291	c.124T>C	c.(124-126)TTG>CTG	p.L42L	CENPW_uc003qap.3_RNA	NM_001012507	NP_001012525	Q5EE01	CENPW_HUMAN	hypothetical protein LOC387103	42						chromosome, centromeric region|nucleus	DNA binding				0						TGGTGACTTATTGGTGAGATT	0.512													16	78					0	0	0	0	C	126661543	C	C	126661543	2	2	102	1	0	0	0	0	0	0	0	1	3259	1490	52	5		5	CENPW	6	126661543	Silent	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	9782417	126661543	44453524	37	19397											
SF3B5	83443	broad.mit.edu	37	chr6	144416375	144416375	+	Nonstop_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggtggtaaggcagagtctCagttctcctcgggcttgtcg	5	11	15	10	3	2	1	1	0	2	1	6	1	2	1	1	4	0	4	1	4	1	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr6:144416375C>G	uc003qkr.1	-	1	380	c.260G>C	c.(259-261)TGA>TCA	p.*87S		NM_031287	NP_112577	Q9BWJ5	SF3B5_HUMAN	SF3b10	87					nuclear mRNA splicing, via spliceosome	nucleoplasm|U12-type spliceosomal complex					0				OV - Ovarian serous cystadenocarcinoma(155;1.68e-06)|GBM - Glioblastoma multiforme(68;0.0638)		GGCAGAGTCTCAGTTCTCCTC	0.567													21	133					0	0	0	0	G	144416375	G	G	144416375	4	3	102	1	0	0	0	0	0	0	0	0	14219	837	29	2	4	2	SF3B5	6	144416375	Nonstop_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	17754832	144416375	26698692	38	19398											
C6orf70	55780	broad.mit.edu	37	chr6	170155405	170155405	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctggattactggggaagcGtgaggctgctgggccctgtg	5	10	18	8	1	1	1	0	1	1	0	1	3	1	3	1	5	3	2	1	5	2	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr6:170155405G>A	uc003qxg.1	+	3	235	c.202G>A	c.(202-204)GTG>ATG	p.V68M	C6orf70_uc011ehb.1_Translation_Start_Site|C6orf70_uc003qxh.1_Missense_Mutation_p.V68M|C6orf70_uc010kky.1_Translation_Start_Site	NM_018341	NP_060811	Q5T6L9	CF070_HUMAN	hypothetical protein LOC55780	68						integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		CTGGGGAAGCGTGAGGCTGCT	0.443													16	132					0	0	0	0	A	170155405	A	A	170155405	3	1	102	1	0	0	0	0	1	0	0	0	2380	1145	40	1	212	1	C6orf70	6	170155405	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	25739030	170155405	959662	39	19399											
ETV1	2115	broad.mit.edu	37	chr7	13950933	13950933	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagtggcagctaggcacttCtgaaagaggaaacaatattg	14	8	13	6	0	1	2	0	1	1	1	1	4	1	4	0	4	2	3	0	4	5	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr7:13950933C>G	uc011jxq.1	-	10	1542	c.803_splice	c.e10-1	p.E268_splice	ETV1_uc011jxn.1_Splice_Site_p.E228_splice|ETV1_uc011jxo.1_Splice_Site_p.E165_splice|ETV1_uc011jxp.1_Splice_Site_p.E210_splice|ETV1_uc003ssw.3_Intron|ETV1_uc003ssx.2_Splice_Site|ETV1_uc011jxr.1_Splice_Site_p.E250_splice|ETV1_uc011jxs.1_Splice_Site_p.E250_splice|ETV1_uc010ktv.2_Splice_Site_p.E137_splice	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a						transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						CTAGGCACTTCTGAAAGAGGA	0.463			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								7	26					0	0	0	0	G	13950933	G	G	13950933	5	3	102	1	0	0	0	0	0	0	1	0	5301	927	32	2	651	2	ETV1	7	13950933	Splice_Site	SNP	C	TCGA-CQ-6220-01A-11D-1912-08		13950933	145187730	40	19400											
RNF148	378925	broad.mit.edu	37	chr7	122342351	122342351	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggttgcttatcatcaccgCgactatattttccgtcccct	7	14	6	14	3	2	0	2	0	0	0	4	1	4	0	4	1	1	2	4	1	3	6			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr7:122342351C>T	uc003vkk.1	-	1	671	c.454G>A	c.(454-456)GCG>ACG	p.A152T	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron|RNF148_uc010lkr.1_Missense_Mutation_p.A54T	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	ring finger protein 148 precursor	152	PA.					integral to membrane	zinc ion binding				0						ATCATCACCGCGACTATATTT	0.463													92	223					0	0	0	0	T	122342351	T	T	122342351	3	4	102	1	0	0	0	0	1	0	0	0	13514	768	27	1	467	1	RNF148	7	122342351	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	108391418	122342351	36796312	41	19401											
EXOC4	60412	broad.mit.edu	37	chr7	133682292	133682292	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaacacggatctccccccaGtgtcagagcagatcatgcag	11	6	10	14	2	3	2	2	0	1	2	4	4	3	3	3	1	3	2	3	1	1	0			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr7:133682292G>C	uc003vrk.2	+	15	2289	c.2254G>C	c.(2254-2256)GTG>CTG	p.V752L	EXOC4_uc011kpo.1_Missense_Mutation_p.V651L|EXOC4_uc003vrl.2_Missense_Mutation_p.V362L|EXOC4_uc011kpp.1_Missense_Mutation_p.V284L|EXOC4_uc011kpq.1_Missense_Mutation_p.V40L	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	752					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				TCTCCCCCCAGTGTCAGAGCA	0.463													14	36					0	0	0	0	C	133682292	C	C	133682292	3	2	102	1	0	0	0	0	1	0	0	0	5330	1029	36	4	2321	4	EXOC4	7	133682292	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	11339941	133682292	25456371	42	19402											
OR2A2	442361	broad.mit.edu	37	chr7	143807496	143807496	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggagcaggagaaaatgctgtCcctgtttcacagtgtcttta	10	12	11	8	0	2	1	1	0	1	1	3	3	3	2	1	2	2	3	1	2	3	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr7:143807496C>G	uc011ktz.1	+	1	821	c.821C>G	c.(820-822)TCC>TGC	p.S274C		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					AAAATGCTGTCCCTGTTTCAC	0.512													64	153					0	0	0	0	G	143807496	G	G	143807496	3	3	102	1	0	0	0	0	1	0	0	0	11031	855	30	2	823	2	OR2A2	7	143807496	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	10125204	143807496	15331167	43	19403											
XRCC2	7516	broad.mit.edu	37	chr7	152346214	152346214	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtgggtgctactactgcagTacaccaaaaaaaatcttccc	14	9	7	11	0	1	0	0	0	1	0	2	0	2	0	2	1	5	3	2	1	7	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr7:152346214T>A	uc003wld.2	-	3	442	c.356A>T	c.(355-357)TAC>TTC	p.Y119F		NM_005431	NP_005422	O43543	XRCC2_HUMAN	X-ray repair cross complementing protein 2	119					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			breast(1)|liver(1)	2		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		ACTACTGCAGTACACCAAAAA	0.398								Homologous_recombination					5	53					0	0	0	0	A	152346214	A	A	152346214	3	1	102	1	0	0	0	0	1	0	0	0	17521	1638	57	5	490	5	XRCC2	7	152346214	Missense_Mutation	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	8538718	152346214	6792449	44	19404											
NCAPG2	54892	broad.mit.edu	37	chr7	158476042	158476042	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctcggaaggtgtatcccgtGgaacatgaagtcctggatgc	9	9	13	10	2	0	1	0	1	0	0	3	4	2	4	3	4	2	1	3	4	4	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr7:158476042G>A	uc003wnv.1	-	9	1019	c.874C>T	c.(874-876)CAC>TAC	p.H292Y	NCAPG2_uc010lqu.1_Missense_Mutation_p.H84Y|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Missense_Mutation_p.H292Y|NCAPG2_uc011kwe.1_Missense_Mutation_p.H292Y	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	292					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		TGTATCCCGTGGAACATGAAG	0.438													18	117					0	0	0	0	A	158476042	A	A	158476042	3	1	102	1	0	0	0	0	1	0	0	0	10262	1348	47	4	2637	4	NCAPG2	7	158476042	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	6129828	158476042	662621	45	19405											
TUSC3	7991	broad.mit.edu	37	chr8	15517104	15517104	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttttgacctccaaagaattgGatttgcagctgagcaactag	12	12	9	8	0	0	3	0	2	0	1	1	4	1	4	2	1	4	3	2	1	4	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr8:15517104G>A	uc003wwt.2	+	4	725	c.515G>A	c.(514-516)GGA>GAA	p.G172E	TUSC3_uc003wwr.2_Missense_Mutation_p.G172E|TUSC3_uc003wws.2_Missense_Mutation_p.G172E|TUSC3_uc003wwu.2_Missense_Mutation_p.G172E|TUSC3_uc003wwv.2_Missense_Mutation_p.G172E|TUSC3_uc003www.2_Missense_Mutation_p.G172E|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.G172E	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	172					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		CAAAGAATTGGATTTGCAGCT	0.393													12	77					0	0	0	0	A	15517104	A	A	15517104	3	1	102	1	0	0	0	0	1	0	0	0	16846	1174	41	2	529	2	TUSC3	8	15517104	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		15517104	130846918	46	19406											
ANK1	286	broad.mit.edu	37	chr8	41581097	41581097	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccccgatccagcagcagccGcaccatgatcacgttgcccc	8	6	8	19	3	1	1	1	1	0	0	3	2	3	1	7	0	4	4	7	0	0	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr8:41581097G>T	uc003xok.2	-	8	850	c.766C>A	c.(766-768)CGG>AGG	p.R256R	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Silent_p.R256R|ANK1_uc003xoj.2_Silent_p.R256R|ANK1_uc003xol.2_Silent_p.R256R|ANK1_uc003xom.2_Silent_p.R289R	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	256	ANK 7.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			AGCAGCAGCCGCACCATGATC	0.647													24	65					5.49717e-05	6.71127e-05	1	0	T	41581097	T	T	41581097	2	4	102	1	0	0	0	0	0	0	0	1	620	1086	38	3		3	ANK1	8	41581097	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	26063993	41581097	104782925	47	19407											
MATN2	4147	broad.mit.edu	37	chr8	99040003	99040003	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagcagccattgtgttcaccGacggacgggctcaggatgac	9	7	14	11	3	2	1	2	1	0	0	2	5	2	3	2	3	2	3	2	3	0	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr8:99040003G>A	uc003yic.2	+	14	2533	c.2302G>A	c.(2302-2304)GAC>AAC	p.D768N	MATN2_uc010mbh.1_Missense_Mutation_p.D727N|MATN2_uc003yid.2_Missense_Mutation_p.D768N|MATN2_uc003yie.1_Missense_Mutation_p.D768N|MATN2_uc010mbi.1_Missense_Mutation_p.D601N|MATN2_uc010mbj.1_Intron|RPL30_uc010mbk.1_Intron	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	768	VWFA 2.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TGTGTTCACCGACGGACGGGC	0.562													9	60					0	0	0	0	A	99040003	A	A	99040003	3	1	102	1	0	0	0	0	1	0	0	0	9387	1058	37	1	2352	1	MATN2	8	99040003	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	57458906	99040003	47324019	48	19408											
CSMD3	114788	broad.mit.edu	37	chr8	113259313	113259313	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggtgcgtgttgtagacccTtggagaaggtgtcctttttt	6	15	13	7	1	0	2	0	0	0	2	1	3	1	2	2	3	1	2	2	3	2	6			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr8:113259313T>A	uc003ynu.2	-	64	10317	c.10158A>T	c.(10156-10158)CAA>CAT	p.Q3386H	CSMD3_uc003yns.2_Missense_Mutation_p.Q2588H|CSMD3_uc003ynt.2_Missense_Mutation_p.Q3346H|CSMD3_uc011lhx.1_Missense_Mutation_p.Q3217H	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3386	Extracellular (Potential).|Sushi 27.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTGTAGACCCTTGGAGAAGGT	0.408										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	38					0	0	0	0	A	113259313	A	A	113259313	3	1	102	1	0	0	0	0	1	0	0	0	3963	1606	56	5	997	5	CSMD3	8	113259313	Missense_Mutation	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	14219310	113259313	33104709	49	19409											
CSMD3	114788	broad.mit.edu	37	chr8	113585877	113585877	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagtcgttttatcttttcCatcataaatctgcaaaatat	13	17	4	7	1	3	1	1	1	2	0	5	1	4	1	1	0	1	2	1	0	6	6			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr8:113585877C>G	uc003ynu.2	-	24	4054	c.3895G>C	c.(3895-3897)GGA>CGA	p.G1299R	CSMD3_uc003yns.2_Missense_Mutation_p.G571R|CSMD3_uc003ynt.2_Missense_Mutation_p.G1259R|CSMD3_uc011lhx.1_Missense_Mutation_p.G1195R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1299	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTATCTTTTCCATCATAAATC	0.308										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	44					0	0	0	0	G	113585877	G	G	113585877	3	3	102	1	0	0	0	0	1	0	0	0	3963	603	21	4	7420	4	CSMD3	8	113585877	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	326564	113585877	32778145	50	19410											
EXT1	2131	broad.mit.edu	37	chr8	119122780	119122780	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcaaattgtgcacatacTgaggtgacaactggtctctg	11	12	9	9	0	2	2	1	2	2	0	4	2	2	2	0	2	3	1	0	2	3	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr8:119122780T>C	uc003yok.1	-	1	1279	c.506A>G	c.(505-507)CAG>CGG	p.Q169R		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	169	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			GTGCACATACTGAGGTGACAA	0.488			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				27	177					0	0	0	0	C	119122780	C	C	119122780	3	2	102	1	0	0	0	0	1	0	0	0	5348	1580	55	5	1778	5	EXT1	8	119122780	Missense_Mutation	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	5536903	119122780	27241242	51	19411											
ENPP2	5168	broad.mit.edu	37	chr8	120629779	120629779	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggaagccatccacggagaaGatgattaatggagggcgaac	14	5	14	8	3	0	3	0	1	0	2	1	7	1	5	2	4	2	0	2	4	4	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr8:120629779G>C	uc003yot.1	-	6	590	c.504C>G	c.(502-504)ATC>ATG	p.I168M	ENPP2_uc003yos.1_Missense_Mutation_p.I168M|ENPP2_uc010mdd.1_Missense_Mutation_p.I168M	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	168					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CCACGGAGAAGATGATTAATG	0.373													8	18					0	0	0	0	C	120629779	C	C	120629779	3	2	102	1	0	0	0	0	1	0	0	0	5154	932	33	2	2406	2	ENPP2	8	120629779	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	1506999	120629779	25734243	52	19412											
FAM135B	51059	broad.mit.edu	37	chr8	139164784	139164784	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agggctccctcagggtagaaCttagtggatcacagggctca	10	8	13	10	0	3	1	3	0	0	1	4	2	4	2	1	4	1	3	1	4	3	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr8:139164784C>T	uc003yuy.2	-	13	2105	c.1934G>A	c.(1933-1935)AGT>AAT	p.S645N	FAM135B_uc003yux.2_Missense_Mutation_p.S546N|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.S207N|FAM135B_uc003yvb.2_Missense_Mutation_p.S207N	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	645										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAGGGTAGAACTTAGTGGATC	0.488										HNSCC(54;0.14)			14	66					0	0	0	0	T	139164784	T	T	139164784	3	4	102	1	0	0	0	0	1	0	0	0	5477	565	20	4	2318	4	FAM135B	8	139164784	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	18535005	139164784	7199238	53	19413											
KCNK9	51305	broad.mit.edu	37	chr8	140630759	140630759	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagactgcaggtccgggacGtccgccttgtacctgggccg	6	7	14	14	4	0	1	0	0	0	1	2	2	2	2	5	3	2	2	5	3	1	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr8:140630759G>A	uc003yvf.1	-	2	931	c.867C>T	c.(865-867)GAC>GAT	p.D289D	KCNK9_uc003yvg.1_Silent_p.D289D|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	289	Cytoplasmic (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			GGTCCGGGACGTCCGCCTTGT	0.657													12	75					0	0	0	0	A	140630759	A	A	140630759	2	1	102	1	0	0	0	0	0	0	0	1	8111	1136	40	1		1	KCNK9	8	140630759	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	1465975	140630759	5733263	54	19414											
CDKN2A	1029	broad.mit.edu	37	chr9	21974703	21974703	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcctccgaccgtaactatTcggtgcgttgggcagcgccc	5	8	13	15	6	0	0	0	0	0	0	2	1	1	0	4	3	3	3	4	3	2	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr9:21974703T>G	uc003zpk.2	-	1	336	c.124A>C	c.(124-126)AAT>CAT	p.N42H	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Missense_Mutation_p.N42H|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	42					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(23)|p.N42Y(1)|p.V28_V51del(1)|p.N42T(1)|p.N42D(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCGTAACTATTCGGTGCGTTG	0.692		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			76	55					0	0	0	0	G	21974703	G	G	21974703	3	3	102	1	0	0	0	0	1	0	0	0	3176	1783	62	5	559	5	CDKN2A	9	21974703	Missense_Mutation	SNP	T	TCGA-CQ-6220-01A-11D-1912-08		21974703	119238728	55	19415											
TXNDC8	255220	broad.mit.edu	37	chr9	113096542	113096542	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggaccacaccgtttcgaaGaaaattgaaccactgcgagt	14	7	10	10	3	0	2	0	1	0	1	1	5	0	3	3	1	2	1	3	1	4	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr9:113096542G>C	uc004bes.2	-	2	132	c.83C>G	c.(82-84)TCT>TGT	p.S28C	TXNDC8_uc011lwl.1_Missense_Mutation_p.S28C	NM_001003936	NP_001003936	Q6A555	TXND8_HUMAN	thioredoxin domain containing 8	28	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	Golgi apparatus	electron carrier activity|protein disulfide oxidoreductase activity				0						CCGTTTCGAAGAAAATTGAAC	0.363													7	30					0	0	0	0	C	113096542	C	C	113096542	3	2	102	1	0	0	0	0	1	0	0	0	16869	942	33	2	284	2	TXNDC8	9	113096542	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	91121839	113096542	28116889	56	19416											
NOTCH1	4851	broad.mit.edu	37	chr9	139412593	139412594	+	Frame_Shift_Ins	INS	-	GA	GA																															tgtgctggcacctacccagcINSgagcactcatccacgtcctg																										TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr9:139412593_139412594insGA	uc004chz.2	-	7	1250_1251	c.1250_1251insTC	c.(1249-1251)TCGfs	p.S417fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	417	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACCTACCCAGCGAGCACTCATC	0.663			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								GA	139412594	GA	GA	139412593	7	5	102	1	0	1	1	0	0	0	0	0	10601	755	27	0	6528	0	NOTCH1	9	139412593	Frame_Shift_Ins	INS	-	TCGA-CQ-6220-01A-11D-1912-08	26316051	139412593	1800838	57	19417											
DNAJC1	64215	broad.mit.edu	37	chr10	22209789	22209789	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acccactgtgagaataatgaAcaagagtaatgccagctcag	16	7	9	9	0	1	3	1	2	0	2	1	4	1	3	2	0	3	2	2	0	5	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr10:22209789A>G	uc001irc.2	-	4	762	c.475T>C	c.(475-477)TTC>CTC	p.F159L	DNAJC1_uc001ird.2_Missense_Mutation_p.F45L	NM_022365	NP_071760	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	159	Helical; (Potential).				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			lung(1)	1		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				AGAATAATGAACAAGAGTAAT	0.408													3	85					0	0	0	0	G	22209789	G	G	22209789	3	3	102	1	0	0	0	0	1	0	0	0	4650	43	2	5	1225	5	DNAJC1	10	22209789	Missense_Mutation	SNP	A	TCGA-CQ-6220-01A-11D-1912-08		22209789	113324958	58	19418											
PPA1	5464	broad.mit.edu	37	chr10	71974336	71974336	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atcattgtgccctgggtcttCccaagtctaaaaatataaga	13	12	7	9	0	3	1	1	0	2	1	4	1	4	1	2	1	1	0	2	1	6	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr10:71974336C>A	uc001jqv.1	-	5	411	c.304G>T	c.(304-306)GAA>TAA	p.E102*		NM_021129	NP_066952	Q15181	IPYR_HUMAN	pyrophosphatase 1	102					diphosphate metabolic process|tRNA aminoacylation for protein translation	cytosol	inorganic diphosphatase activity|magnesium ion binding			breast(1)	1						CCTGGGTCTTCCCAAGTCTAA	0.363													10	43					2.17888e-05	2.67652e-05	1	0	A	71974336	A	A	71974336	4	1	102	1	0	0	0	0	0	1	0	0	12341	864	30	2	593	2	PPA1	10	71974336	Nonsense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	49764547	71974336	63560411	59	19419											
SFTPA1	653509	broad.mit.edu	37	chr10	81373513	81373513	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcagtctgcagggctccAtaatgacagtaggagagaag	12	7	12	10	0	2	2	1	1	1	1	3	4	3	3	2	2	1	3	2	2	3	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr10:81373513A>G	uc001kap.2	+	6	512	c.391A>G	c.(391-393)ATA>GTA	p.I131V	SFTPA1_uc001kaq.2_Missense_Mutation_p.I131V|SFTPA1_uc009xry.2_Missense_Mutation_p.I146V|SFTPA1_uc001kar.2_Missense_Mutation_p.I131V|SFTPA1_uc010qlt.1_Missense_Mutation_p.I72V|SFTPA1_uc009xrz.2_Missense_Mutation_p.I61V|SFTPA1_uc009xsa.2_Missense_Mutation_p.I131V|SFTPA1_uc009xsf.2_RNA	NM_005411	NP_005402	Q8IWL2	SFTA1_HUMAN	surfactant protein A1 isoform 1	131					cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			GCAGGGCTCCATAATGACAGT	0.572													24	146					0	0	0	0	G	81373513	G	G	81373513	3	3	102	1	0	0	0	0	1	0	0	0	14254	217	8	5	454	5	SFTPA1	10	81373513	Missense_Mutation	SNP	A	TCGA-CQ-6220-01A-11D-1912-08	9399177	81373513	54161234	60	19420											
ACTA2	59	broad.mit.edu	37	chr10	90707026	90707026	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcccataccttttccatgtCgtcccagttggtgatgatgc	6	14	8	13	1	0	2	0	2	0	0	4	2	3	2	4	1	2	1	4	1	1	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr10:90707026C>T	uc001kfp.2	-	3	363	c.247G>A	c.(247-249)GAC>AAC	p.D83N	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Missense_Mutation_p.D38N|ACTA2_uc001kfq.2_Missense_Mutation_p.D83N|ACTA2_uc010qmz.1_Missense_Mutation_p.D83N	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	83					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		TTTTCCATGTCGTCCCAGTTG	0.502													28	141					0	0	0	0	T	90707026	T	T	90707026	3	4	102	1	0	0	0	0	1	0	0	0	192	884	31	1	914	1	ACTA2	10	90707026	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	9333513	90707026	44827721	61	19421											
PDE6C	5146	broad.mit.edu	37	chr10	95415576	95415576	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaacagttattcatttgttCgaggtcgcaataatagcaac	14	12	8	7	2	1	0	1	0	0	0	3	2	1	0	0	1	3	4	0	1	6	6			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr10:95415576C>T	uc001kiu.3	+	16	2133	c.1995C>T	c.(1993-1995)TTC>TTT	p.F665F		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	665					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				TTCATTTGTTCGAGGTCGCAA	0.348													52	113					0	0	0	0	T	95415576	T	T	95415576	2	4	102	1	0	0	0	0	0	0	0	1	11701	883	31	1		1	PDE6C	10	95415576	Silent	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	4708550	95415576	40119171	62	19422											
RRP12	23223	broad.mit.edu	37	chr10	99130758	99130758	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaggtggctctgcacgaaGagggccccggggccctgagg	6	5	17	13	2	1	2	0	1	1	1	2	3	2	2	4	6	1	2	4	6	1	0			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr10:99130758G>C	uc001knf.2	-	21	2563	c.2424C>G	c.(2422-2424)CTC>CTG	p.L808L	RRP12_uc009xvl.2_5'UTR|RRP12_uc009xvm.2_Silent_p.L526L|RRP12_uc010qou.1_Silent_p.L747L|RRP12_uc009xvn.2_Silent_p.L708L	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	808						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TCTGCACGAAGAGGGCCCCGG	0.667													8	30					0	0	0	0	C	99130758	C	C	99130758	2	2	102	1	0	0	0	0	0	0	0	1	13751	929	33	2		2	RRP12	10	99130758	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	3715182	99130758	36403989	63	19423											
SORCS3	22986	broad.mit.edu	37	chr10	106960922	106960922	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggaaaatattcaagaaacgTaagccaggagctcagtgtgc	16	7	11	7	1	2	1	2	0	0	1	2	3	2	3	1	2	4	2	1	2	6	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr10:106960922T>A	uc001kyi.1	+	16	2399	c.2172T>A	c.(2170-2172)CGT>CGA	p.R724R	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	724	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCAAGAAACGTAAGCCAGGAG	0.468													10	71					0	0	0	0	A	106960922	A	A	106960922	2	1	102	1	0	0	0	0	0	0	0	1	14996	1625	57	5		5	SORCS3	10	106960922	Silent	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	7830164	106960922	28573825	64	19424											
VWA2	340706	broad.mit.edu	37	chr10	116045996	116045996	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcggcaggcggcagagcgTggcttcgggagcgccaccag	6	5	18	12	5	0	1	0	0	0	1	1	2	0	2	2	5	3	3	2	5	0	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr10:116045996T>C	uc001lbl.1	+	11	1617	c.1296T>C	c.(1294-1296)CGT>CGC	p.R432R	VWA2_uc001lbk.1_Silent_p.R432R|VWA2_uc009xyf.1_Silent_p.R128R	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	432	VWFA 2.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		CGGCAGAGCGTGGCTTCGGGA	0.662													13	90					0	0	0	0	C	116045996	C	C	116045996	2	2	102	1	0	0	0	0	0	0	0	1	17307	1683	59	5		5	VWA2	10	116045996	Silent	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	9085074	116045996	19488751	65	19425											
OR51I2	390064	broad.mit.edu	37	chr11	5475596	5475596	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcaaccctctcatttataGcgccaagacaaaggaaatcc	14	8	6	13	1	2	1	2	0	1	1	4	2	3	2	3	1	2	1	3	1	6	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:5475596G>C	uc010qzf.1	+	1	878	c.878G>C	c.(877-879)AGC>ACC	p.S293T	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	293	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCATTTATAGCGCCAAGACA	0.443													8	151					0	0	0	0	C	5475596	C	C	5475596	3	2	102	1	0	0	0	0	1	0	0	0	11155	971	34	4	880	4	OR51I2	11	5475596	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		5475596	129530920	66	19426											
CNGA4	1262	broad.mit.edu	37	chr11	6261383	6261383	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtttcttcttggacctggCttccctgatgcccacagatg	6	13	10	12	0	2	2	0	1	2	1	3	4	3	3	3	2	1	2	3	2	0	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:6261383C>T	uc001mco.2	+	4	466	c.359C>T	c.(358-360)GCT>GTT	p.A120V	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.A80V	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	120	Helical; Name=H3; (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTGGACCTGGCTTCCCTGATG	0.627													56	141					0	0	0	0	T	6261383	T	T	6261383	3	4	102	1	0	0	0	0	1	0	0	0	3614	797	28	4	373	4	CNGA4	11	6261383	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	785787	6261383	128745133	67	19427											
OR10A6	390093	broad.mit.edu	37	chr11	7949672	7949672	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctaacactgctggggtttCacaagatatatggttaattt	11	16	8	6	0	2	1	1	0	1	1	2	1	2	1	0	3	2	3	0	3	5	7	rs145835770		TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:7949672C>T	uc010rbh.1	-	1	538	c.538G>A	c.(538-540)GAA>AAA	p.E180K		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E180K(1)		ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCTGGGGTTTCACAAGATATA	0.363													6	33					0	0	0	0	T	7949672	T	T	7949672	3	4	102	1	0	0	0	0	1	0	0	0	10948	835	29	2	409	2	OR10A6	11	7949672	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	1688289	7949672	127056844	68	19428											
OSBP	5007	broad.mit.edu	37	chr11	59376031	59376031	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgatcttttcattgctctCagcaggcaacttcagggact	8	15	8	10	0	4	1	3	1	2	0	5	2	4	2	0	2	3	3	0	2	1	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:59376031C>G	uc001noc.1	-	3	1228	c.748G>C	c.(748-750)GAG>CAG	p.E250Q		NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	250					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TCATTGCTCTCAGCAGGCAAC	0.488													29	65					0	0	0	0	G	59376031	G	G	59376031	3	3	102	1	0	0	0	0	1	0	0	0	11327	835	29	2	1723	2	OSBP	11	59376031	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	51426359	59376031	75630485	69	19429											
MS4A5	64232	broad.mit.edu	37	chr11	60197290	60197290	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attatttgctagaaaaatgaAaatcttaggggtaagtaaga	18	12	9	2	0	1	3	0	1	1	2	1	3	1	3	0	2	1	3	0	2	9	6			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:60197290A>T	uc001npo.2	+	1	229	c.143A>T	c.(142-144)AAA>ATA	p.K48I		NM_023945	NP_076434	Q9H3V2	MS4A5_HUMAN	membrane-spanning 4-domains, subfamily A, member	48	Cytoplasmic (Potential).					integral to membrane	receptor activity			large_intestine(1)|ovary(1)	2						AGAAAAATGAAAATCTTAGGG	0.418													4	73					0	0	0	0	T	60197290	T	T	60197290	3	4	102	1	0	0	0	0	1	0	0	0	9916	14	1	5	145	5	MS4A5	11	60197290	Missense_Mutation	SNP	A	TCGA-CQ-6220-01A-11D-1912-08	821259	60197290	74809226	70	19430											
AHNAK	79026	broad.mit.edu	37	chr11	62286423	62286423	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggcctttcaggtcaccctCtatttttggcactgagatgt	6	14	11	10	0	3	1	2	1	1	1	3	2	3	1	2	4	0	1	2	4	1	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:62286423C>G	uc001ntl.2	-	5	15766	c.15466G>C	c.(15466-15468)GAG>CAG	p.E5156Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5156					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGGTCACCCTCTATTTTTGGC	0.507													11	68					0	0	0	0	G	62286423	G	G	62286423	3	3	102	1	0	0	0	0	1	0	0	0	414	922	32	2	2326	2	AHNAK	11	62286423	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	2089133	62286423	72720093	71	19431											
ANO1	55107	broad.mit.edu	37	chr11	69933944	69933944	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cggcgcaaggtggactacatCctggtgtaccatcacaagag	11	7	12	11	2	1	1	1	0	0	1	2	2	2	2	2	4	2	2	2	4	4	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:69933944C>T	uc001opj.2	+	2	500	c.195C>T	c.(193-195)ATC>ATT	p.I65I	ANO1_uc001opk.1_Silent_p.I37I|ANO1_uc001opl.1_RNA	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	65	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						TGGACTACATCCTGGTGTACC	0.617													6	27					0	0	0	0	T	69933944	T	T	69933944	2	4	102	1	0	0	0	0	0	0	0	1	695	845	30	2		2	ANO1	11	69933944	Silent	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	7647521	69933944	65072572	72	19432											
FCHSD2	9873	broad.mit.edu	37	chr11	72554523	72554523	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcttccatatctccatcttCaatcacttctaacacctcat	10	15	1	15	0	7	0	3	0	4	0	9	0	8	0	3	0	1	0	3	0	3	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:72554523C>T	uc009ytl.2	-	15	1719	c.1498G>A	c.(1498-1500)GAA>AAA	p.E500K	FCHSD2_uc010rrg.1_Missense_Mutation_p.E364K|FCHSD2_uc001oth.3_Missense_Mutation_p.E444K|FCHSD2_uc001oti.2_Missense_Mutation_p.E459K|ATG16L2_uc009ytj.1_3'UTR	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	500	SH3 1.						protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			TCTCCATCTTCAATCACTTCT	0.403													19	98					0	0	0	0	T	72554523	T	T	72554523	3	4	102	1	0	0	0	0	1	0	0	0	5822	835	29	2	748	2	FCHSD2	11	72554523	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	2620579	72554523	62451993	73	19433											
FAM181B	220382	broad.mit.edu	37	chr11	82444469	82444469	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaggccgctgcagcgcttGatctgcttctgcaggtactt	6	12	12	11	2	2	2	0	2	2	0	2	2	2	2	1	2	5	6	1	2	1	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:82444469G>C	uc001ozp.2	-	1	438	c.303C>G	c.(301-303)ATC>ATG	p.I101M		NM_175885	NP_787081	A6NEQ2	F181B_HUMAN	hypothetical protein LOC220382	101										large_intestine(1)	1						TGCAGCGCTTGATCTGCTTCT	0.507													4	10					0	0	0	0	C	82444469	C	C	82444469	3	2	102	1	0	0	0	0	1	0	0	0	5537	1280	45	2	981	2	FAM181B	11	82444469	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	9889946	82444469	52562047	74	19434											
FAT3	120114	broad.mit.edu	37	chr11	92085885	92085885	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actttaaaaataaagttgatCtcttttcagttcaccccacg	13	14	4	10	1	3	1	2	1	1	0	4	1	3	1	2	0	0	2	2	0	5	7			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:92085885C>T	uc001pdj.3	+	1	624	c.607C>T	c.(607-609)CTC>TTC	p.L203F		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	203	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TAAAGTTGATCTCTTTTCAGT	0.408										TCGA Ovarian(4;0.039)			14	76					0	0	0	0	T	92085885	T	T	92085885	3	4	102	1	0	0	0	0	1	0	0	0	5723	913	32	2	609	2	FAT3	11	92085885	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	9641416	92085885	42920631	75	19435											
OAF	220323	broad.mit.edu	37	chr11	120082137	120082137	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accgaggagagcctgcaggcGgacagcgacgcggacagcat	11	2	16	12	5	0	1	0	0	0	1	0	6	0	3	2	4	4	2	2	4	0	0			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:120082137G>A	uc001pxb.2	+	1	391	c.150G>A	c.(148-150)GCG>GCA	p.A50A		NM_178507	NP_848602	Q86UD1	OAF_HUMAN	OAF homolog precursor	50											0		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)		GCCTGCAGGCGGACAGCGACG	0.637													3	13					0	0	0	0	A	120082137	A	A	120082137	2	1	102	1	0	0	0	0	0	0	0	1	10852	1103	39	1		1	OAF	11	120082137	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	27996252	120082137	14924379	76	19436											
ARHGAP32	9743	broad.mit.edu	37	chr11	128839602	128839602	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atagaagcggtcctctccctCgggactgatggccttggctg	6	10	13	12	2	1	2	0	1	1	1	4	3	2	3	3	4	1	1	3	4	2	2	rs138669502		TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr11:128839602C>T	uc009zcp.2	-	22	5464	c.5464G>A	c.(5464-5466)GAG>AAG	p.E1822K	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.E781K|ARHGAP32_uc001qez.2_Missense_Mutation_p.E1473K	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1822	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						TCCTCTCCCTCGGGACTGATG	0.577													17	69					0	0	0	0	T	128839602	T	T	128839602	3	4	102	1	0	0	0	0	1	0	0	0	881	893	31	1	803	1	ARHGAP32	11	128839602	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	8757465	128839602	6166914	77	19437											
CACNA2D4	93589	broad.mit.edu	37	chr12	1993939	1993939	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgggagggtcaccttacAgtctggccagttatacttct	7	12	11	11	1	3	0	1	0	2	0	3	1	3	1	3	3	2	1	3	3	3	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:1993939A>T	uc001qjp.2	-	11	1498	c.1267T>A	c.(1267-1269)TGT>AGT	p.C423S	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.C342S	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	423	VWFA.|Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GTCACCTTACAGTCTGGCCAG	0.582													7	20					0	0	0	0	T	1993939	T	T	1993939	3	4	102	1	0	0	0	0	1	0	0	0	2563	188	7	5	2258	5	CACNA2D4	12	1993939	Missense_Mutation	SNP	A	TCGA-CQ-6220-01A-11D-1912-08		1993939	131857956	78	19438											
SLC38A1	81539	broad.mit.edu	37	chr12	46591510	46591510	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaagagacatacccaaattCtttgagttcctttatctcca	12	13	5	11	0	2	2	0	1	2	1	4	3	3	2	3	0	1	2	3	0	4	6			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:46591510C>G	uc001rpa.2	-	16	1613	c.1355G>C	c.(1354-1356)AGA>ACA	p.R452T	SLC38A1_uc001rpb.2_Missense_Mutation_p.R452T|SLC38A1_uc001rpc.2_Missense_Mutation_p.R452T|SLC38A1_uc001rpd.2_Missense_Mutation_p.R452T|SLC38A1_uc001rpe.2_Missense_Mutation_p.R452T|SLC38A1_uc009zkj.1_Missense_Mutation_p.R452T	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	452	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			TACCCAAATTCTTTGAGTTCC	0.328													19	60					0	0	0	0	G	46591510	G	G	46591510	3	3	102	1	0	0	0	0	1	0	0	0	14665	913	32	2	116	2	SLC38A1	12	46591510	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	44597571	46591510	87260385	79	19439											
SLC11A2	4891	broad.mit.edu	37	chr12	51382165	51382165	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcctttagagatgcttacCgtatgcccacagtccaggaa	11	9	10	11	1	0	1	0	0	0	1	1	3	1	2	4	2	3	2	4	2	4	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:51382165C>T	uc001rxe.3	-	16	1726	c.1629G>A	c.(1627-1629)ACG>ACA	p.T543T	SLC11A2_uc001rxd.3_Silent_p.T392T|SLC11A2_uc001rxc.3_Silent_p.T543T|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_Silent_p.T156T|SLC11A2_uc010smx.1_Silent_p.T539T|SLC11A2_uc001rxh.1_Silent_p.T543T|SLC11A2_uc001rxj.1_Silent_p.T543T|SLC11A2_uc001rxi.2_Silent_p.T543T|SLC11A2_uc001rxk.1_Silent_p.T572T|SLC11A2_uc010smy.1_Silent_p.T506T	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	543	Cytoplasmic (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						AGATGCTTACCGTATGCCCAC	0.493													5	75					0	0	0	0	T	51382165	T	T	51382165	2	4	102	1	0	0	0	0	0	0	0	1	14446	666	23	1		1	SLC11A2	12	51382165	Silent	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	4790655	51382165	82469730	80	19440											
DNAJC14	85406	broad.mit.edu	37	chr12	56221128	56221128	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaagggtttagctcatcctCaggaaccccagccatggtca	11	8	10	12	0	3	0	3	0	0	0	4	2	4	1	4	3	3	2	4	3	3	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:56221128C>T	uc001shx.1	-	2	1519	c.1315G>A	c.(1315-1317)GAG>AAG	p.E439K	DNAJC14_uc001shu.1_Missense_Mutation_p.E439K|DNAJC14_uc009zob.1_Missense_Mutation_p.E439K|DNAJC14_uc001shy.1_Missense_Mutation_p.E439K	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	439					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						AGCTCATCCTCAGGAACCCCA	0.527													12	172					0	0	0	0	T	56221128	T	T	56221128	3	4	102	1	0	0	0	0	1	0	0	0	4655	835	29	2	817	2	DNAJC14	12	56221128	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	4838963	56221128	77630767	81	19441											
CS	1431	broad.mit.edu	37	chr12	56677625	56677625	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaccaatcccttcatgcctCtcatgccaccatacatctaa	12	10	3	16	0	3	1	2	0	2	1	5	1	4	1	5	0	3	0	5	0	3	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:56677625C>G	uc001sks.1	-	4	408	c.218G>C	c.(217-219)AGA>ACA	p.R73T	CS_uc010sql.1_Missense_Mutation_p.R60T|CS_uc001skr.1_Missense_Mutation_p.R7T|CS_uc001skt.1_Missense_Mutation_p.R28T|CS_uc010sqm.1_Missense_Mutation_p.R7T	NM_004077	NP_004068	O75390	CISY_HUMAN	citrate synthase precursor	73					cellular carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	citrate (Si)-synthase activity				0		Myeloproliferative disorder(1001;0.000374)		BRCA - Breast invasive adenocarcinoma(357;6.17e-07)		CTTCATGCCTCTCATGCCACC	0.373													5	25					0	0	0	0	G	56677625	G	G	56677625	3	3	102	1	0	0	0	0	1	0	0	0	3939	913	32	2	1214	2	CS	12	56677625	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	456497	56677625	77174270	82	19442											
OS9	10956	broad.mit.edu	37	chr12	58113926	58113926	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtccgggtcaccaagctcCgtctcggaggccctaatcag	7	7	13	14	3	3	0	2	0	1	0	6	1	5	1	4	4	1	1	4	4	2	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:58113926C>T	uc001spj.2	+	13	1704	c.1645C>T	c.(1645-1647)CGT>TGT	p.R549C	OS9_uc010srx.1_Intron|OS9_uc001spk.2_Missense_Mutation_p.R534C|OS9_uc001spl.2_Intron|OS9_uc001spm.2_Intron|OS9_uc001spn.2_Intron|OS9_uc010sry.1_Intron|OS9_uc010srz.1_Intron	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	549					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CACCAAGCTCCGTCTCGGAGG	0.572													29	103					0	0	0	0	T	58113926	T	T	58113926	3	4	102	1	0	0	0	0	1	0	0	0	11326	652	23	1	1695	1	OS9	12	58113926	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	1436301	58113926	75737969	83	19443											
C12orf56	115749	broad.mit.edu	37	chr12	64746823	64746823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggcgaactcaaaaattccGggtaatcatcaatctggaaa	15	9	8	9	2	4	0	3	0	1	0	5	2	5	1	1	3	1	1	1	3	6	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:64746823G>A	uc001ssa.3	-	2	266	c.266C>T	c.(265-267)CCG>CTG	p.P89L	uc001srx.2_Intron	NM_001099676	NP_001093146	Q8IXR9	CL056_HUMAN	hypothetical protein LOC115749	89											0			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		CAAAAATTCCGGGTAATCATC	0.343													6	65					0	0	0	0	A	64746823	A	A	64746823	3	1	102	1	0	0	0	0	1	0	0	0	1706	1116	39	1	1650	1	C12orf56	12	64746823	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	6632897	64746823	69105072	84	19444											
CPSF6	11052	broad.mit.edu	37	chr12	69652600	69652600	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctacggcccccctcctggcCcaccacctccacaacaggga	8	4	8	21	1	0	0	0	0	0	0	2	1	2	1	8	3	2	1	8	3	2	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:69652600C>T	uc001sut.3	+	6	1035	c.925C>T	c.(925-927)CCA>TCA	p.P309S	CPSF6_uc001suu.3_Missense_Mutation_p.P346S|CPSF6_uc010stk.1_5'UTR	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	309	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			CCCTCCTGGCCCACCACCTCC	0.632													20	90					0	0	0	0	T	69652600	T	T	69652600	3	4	102	1	0	0	0	0	1	0	0	0	3844	623	22	4	947	4	CPSF6	12	69652600	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	4905777	69652600	64199295	85	19445											
RILPL2	196383	broad.mit.edu	37	chr12	123915096	123915096	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcctgcaccaccaggagctgCgacttgagtttgttgcgttc	6	12	11	12	2	0	1	0	1	0	0	2	3	1	2	3	1	4	5	3	1	0	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:123915096C>T	uc001uey.1	-	2	747	c.450G>A	c.(448-450)TCG>TCA	p.S150S		NM_145058	NP_659495	Q969X0	RIPL2_HUMAN	Rab interacting lysosomal protein-like 2	150	Potential.|RILP-like.					cytosol|plasma membrane	identical protein binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000546)|Epithelial(86;0.00179)|all cancers(50;0.0168)		CCAGGAGCTGCGACTTGAGTT	0.582													9	155					0	0	0	0	T	123915096	T	T	123915096	2	4	102	1	0	0	0	0	0	0	0	1	13427	755	27	1		1	RILPL2	12	123915096	Silent	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	54262496	123915096	9936799	86	19446											
EP400	57634	broad.mit.edu	37	chr12	132514446	132514446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggctggtgcagttcgactCaggtatgcggcagttggggg	6	9	19	7	2	1	0	1	0	0	0	2	2	1	0	0	6	2	6	0	6	1	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:132514446C>T	uc001ujn.2	+	27	5617	c.5582C>T	c.(5581-5583)TCA>TTA	p.S1861L	EP400_uc001ujl.2_Missense_Mutation_p.S1860L|EP400_uc001ujm.2_Missense_Mutation_p.S1780L|SNORA49_uc001ujo.2_5'Flank	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1897					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CAGTTCGACTCAGGTATGCGG	0.647													9	36					0	0	0	0	T	132514446	T	T	132514446	3	4	102	1	0	0	0	0	1	0	0	0	5173	838	29	2	5685	2	EP400	12	132514446	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	8599350	132514446	1337449	87	19447											
ANKLE2	23141	broad.mit.edu	37	chr12	133306539	133306539	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attttgcaaattcagtttatCaaactcaacagtcaaatccg	15	13	4	9	1	4	0	4	0	0	0	5	0	5	0	1	0	3	2	1	0	5	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr12:133306539C>G	uc001ukx.2	-	11	2276	c.2209G>C	c.(2209-2211)GAT>CAT	p.D737H	ANKLE2_uc009zyw.1_Missense_Mutation_p.D92H	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	737						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TTCAGTTTATCAAACTCAACA	0.473													9	124					0	0	0	0	G	133306539	G	G	133306539	3	3	102	1	0	0	0	0	1	0	0	0	633	826	29	2	619	2	ANKLE2	12	133306539	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	792093	133306539	545356	88	19448											
COL4A2	1284	broad.mit.edu	37	chr13	111111187	111111187	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcttccgggactgccaggacCcaagggcttcgcaggcatca	8	7	12	14	2	2	0	1	0	1	0	4	2	3	2	3	4	1	3	3	4	1	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr13:111111187C>A	uc001vqx.2	+	22	1791	c.1502C>A	c.(1501-1503)CCC>CAC	p.P501H		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	501	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CTGCCAGGACCCAAGGGCTTC	0.637													13	89					7.93312e-07	9.86682e-07	1	0	A	111111187	A	A	111111187	3	1	102	1	0	0	0	0	1	0	0	0	3705	623	22	4	1584	4	COL4A2	13	111111187	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08		111111187	4058691	89	19449											
MYH6	4624	broad.mit.edu	37	chr14	23858093	23858093	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcttcgagctcctcagtccGctgaatggcgtccgtctcat	5	12	9	15	4	3	1	2	1	2	0	8	2	6	1	3	1	1	2	3	1	1	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr14:23858093G>A	uc001wjv.2	-	29	4217	c.4150C>T	c.(4150-4152)CGG>TGG	p.R1384W	uc010tnn.1_5'Flank|MIR208A_hsa-mir-208a|MI0000251_5'Flank	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1384	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCCTCAGTCCGCTGAATGGCG	0.622													45	88					0	0	0	0	A	23858093	A	A	23858093	3	1	102	1	0	0	0	0	1	0	0	0	10091	1086	38	1	1713	1	MYH6	14	23858093	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		23858093	83491447	90	19450											
NUMB	8650	broad.mit.edu	37	chr14	73743879	73743879	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcagctgaggcctggggctGctgagcccggacgctcttag	6	7	16	12	2	1	2	0	2	1	0	1	3	1	3	2	4	4	5	2	4	1	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr14:73743879G>A	uc001xny.1	-	13	1683	c.1363C>T	c.(1363-1365)CAG>TAG	p.Q455*	NUMB_uc010aro.1_Nonsense_Mutation_p.Q260*|NUMB_uc010arp.1_Nonsense_Mutation_p.Q249*|NUMB_uc010arq.1_Nonsense_Mutation_p.Q309*|NUMB_uc010arr.1_Nonsense_Mutation_p.Q298*|NUMB_uc001xoa.1_Nonsense_Mutation_p.Q407*|NUMB_uc001xnz.1_Nonsense_Mutation_p.Q444*|NUMB_uc001xob.1_Nonsense_Mutation_p.Q396*|NUMB_uc001xod.1_Nonsense_Mutation_p.Q407*|NUMB_uc001xoc.1_Nonsense_Mutation_p.Q455*|NUMB_uc010ars.1_Nonsense_Mutation_p.Q444*|NUMB_uc010ttz.1_Nonsense_Mutation_p.Q153*|NUMB_uc001xoe.2_RNA	NM_001005743	NP_001005743	P49757	NUMB_HUMAN	numb homolog isoform 1	455					axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				ovary(2)|central_nervous_system(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		GCCTGGGGCTGCTGAGCCCGG	0.607													15	39					0	0	0	0	A	73743879	A	A	73743879	4	1	102	1	0	0	0	0	0	1	0	0	10805	1328	46	4	596	4	NUMB	14	73743879	Nonsense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	49885786	73743879	33605661	91	19451											
DYNC1H1	1778	broad.mit.edu	37	chr14	102506067	102506067	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaaactgaagggcaccgtGgggtaagagcactcacgccc	12	5	12	12	2	2	2	2	1	0	1	2	2	2	2	2	3	2	3	2	3	3	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr14:102506067G>T	uc001yks.2	+	62	11852	c.11688G>T	c.(11686-11688)GTG>GTT	p.V3896V		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3896					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						AGGGCACCGTGGGGTAAGAGC	0.483													15	84					1.05317e-09	1.33491e-09	1	0	T	102506067	T	T	102506067	2	4	102	1	0	0	0	0	0	0	0	1	4863	1335	47	4		4	DYNC1H1	14	102506067	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	28762188	102506067	4843473	92	19452											
ASPG	374569	broad.mit.edu	37	chr14	104571696	104571696	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccttcggggggagatgaCgccaccctcggtggaagagc	8	5	17	11	3	0	3	0	1	0	2	2	6	0	5	3	6	1	0	3	6	1	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr14:104571696C>T	uc001yoq.1	+	10	1142	c.1082C>T	c.(1081-1083)ACG>ATG	p.T361M	ASPG_uc001yoo.1_Missense_Mutation_p.T389M|ASPG_uc001yop.1_Missense_Mutation_p.T361M|ASPG_uc001yor.1_Missense_Mutation_p.T361M	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	361					lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						GGGGAGATGACGCCACCCTCG	0.672													5	43					0	0	0	0	T	104571696	T	T	104571696	3	4	102	1	0	0	0	0	1	0	0	0	1054	536	19	1	1120	1	ASPG	14	104571696	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	2065629	104571696	2777844	93	19453											
GABRB3	2562	broad.mit.edu	37	chr15	26825502	26825502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attcctcgagaccagacggtGctccacgatggagaactgcg	10	7	12	12	4	0	3	0	0	0	3	3	6	2	3	3	2	3	1	3	2	1	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr15:26825502G>A	uc001zaz.2	-	6	788	c.646C>T	c.(646-648)CAC>TAC	p.H216Y	GABRB3_uc010uae.1_Missense_Mutation_p.H131Y|GABRB3_uc001zba.2_Missense_Mutation_p.H216Y|GABRB3_uc001zbb.2_Missense_Mutation_p.H272Y	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	216	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACCAGACGGTGCTCCACGATG	0.567													15	81					0	0	0	0	A	26825502	A	A	26825502	3	1	102	1	0	0	0	0	1	0	0	0	6202	1319	46	4	791	4	GABRB3	15	26825502	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		26825502	75705890	94	19454											
CTDSPL2	51496	broad.mit.edu	37	chr15	44816367	44816367	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcatgatttgctgcccccaGattaagtacaaagacttgtc	11	12	8	10	0	0	3	0	1	0	2	1	3	0	3	2	0	4	3	2	0	3	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr15:44816367G>C	uc001ztr.2	+	13	1812	c.1396G>C	c.(1396-1398)GAT>CAT	p.D466H	CTDSPL2_uc001zts.2_Missense_Mutation_p.D466H|CTDSPL2_uc001ztt.2_Missense_Mutation_p.D466H|CTDSPL2_uc010bdv.2_Missense_Mutation_p.D394H	NM_016396	NP_057480	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	466							phosphoprotein phosphatase activity				0		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		GCTGCCCCCAGATTAAGTACA	0.383													3	37					0	0	0	0	C	44816367	C	C	44816367	3	2	102	1	0	0	0	0	1	0	0	0	4023	942	33	2	1442	2	CTDSPL2	15	44816367	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	17990865	44816367	57715025	95	19455											
MYO9A	4649	broad.mit.edu	37	chr15	72190735	72190735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcactgagggcattgtccCgtgaatcaaattttggactg	10	11	12	8	1	1	2	1	2	0	0	2	3	2	3	1	3	0	2	1	3	2	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr15:72190735C>T	uc002atl.3	-	25	4582	c.4109G>A	c.(4108-4110)CGG>CAG	p.R1370Q	MYO9A_uc010biq.2_Missense_Mutation_p.R990Q|MYO9A_uc002atn.1_Missense_Mutation_p.R1351Q|MYO9A_uc002atk.2_Missense_Mutation_p.R94Q|MYO9A_uc002atm.1_Missense_Mutation_p.R94Q	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1370	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GGCATTGTCCCGTGAATCAAA	0.443													17	96					0	0	0	0	T	72190735	T	T	72190735	3	4	102	1	0	0	0	0	1	0	0	0	10137	652	23	1	3609	1	MYO9A	15	72190735	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	27374368	72190735	30340657	96	19456											
C15orf42	90381	broad.mit.edu	37	chr15	90168550	90168550	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggggttccttggacaccatCccccaagcacagtgggaaga	10	7	12	12	0	0	1	0	0	0	1	2	3	2	3	4	4	1	2	4	4	2	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr15:90168550C>T	uc002boe.2	+	20	5009	c.5009C>T	c.(5008-5010)TCC>TTC	p.S1670F	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1670					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TGGACACCATCCCCCAAGCAC	0.607													12	57					0	0	0	0	T	90168550	T	T	90168550	3	4	102	1	0	0	0	0	1	0	0	0	1802	855	30	2	5087	2	C15orf42	15	90168550	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	17977815	90168550	12362842	97	19457											
C15orf42	90381	broad.mit.edu	37	chr15	90169002	90169002	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccctccacgggagacgaaGaggtgtttgtttccggtgag	8	10	14	9	3	0	3	0	1	0	2	2	5	2	3	3	3	1	2	3	3	2	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr15:90169002G>C	uc002boe.2	+	20	5461	c.5461G>C	c.(5461-5463)GAG>CAG	p.E1821Q	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1821					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GGGAGACGAAGAGGTGTTTGT	0.478													22	145					0	0	0	0	C	90169002	C	C	90169002	3	2	102	1	0	0	0	0	1	0	0	0	1802	943	33	2	5539	2	C15orf42	15	90169002	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	452	90169002	12362390	98	19458											
CLCN7	1186	broad.mit.edu	37	chr16	1510884	1510884	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgtcaatgaagcaggccacGaggcccgtgaggatcccaat	12	6	12	11	2	1	2	1	2	0	0	2	4	2	3	3	3	1	1	3	3	3	0			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr16:1510884G>A	uc002clv.2	-	5	527	c.417C>T	c.(415-417)CTC>CTT	p.L139L	CLCN7_uc002clw.2_Silent_p.L115L	NM_001287	NP_001278	P51798	CLCN7_HUMAN	chloride channel 7 isoform a	139	Helical; (By similarity).					integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Hepatocellular(780;0.0893)				AGCAGGCCACGAGGCCCGTGA	0.642													18	50					0	0	0	0	A	1510884	A	A	1510884	2	1	102	1	0	0	0	0	0	0	0	1	3483	1045	37	1		1	CLCN7	16	1510884	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		1510884	88843869	99	19459											
CLDN9	9080	broad.mit.edu	37	chr16	3063471	3063471	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggaaggtgaccgccttcatCggcaacagcatcgtggtggc	8	8	14	11	3	1	1	1	1	0	0	3	2	1	2	2	5	2	2	2	5	2	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr16:3063471C>T	uc010uwo.1	+	1	1015	c.108C>T	c.(106-108)ATC>ATT	p.I36I		NM_020982	NP_066192	O95484	CLD9_HUMAN	claudin 9	36	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						CCGCCTTCATCGGCAACAGCA	0.657													18	81					0	0	0	0	T	3063471	T	T	3063471	2	4	102	1	0	0	0	0	0	0	0	1	3507	874	31	1		1	CLDN9	16	3063471	Silent	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	1552587	3063471	87291282	100	19460											
A2BP1	54715	broad.mit.edu	37	chr16	7568266	7568266	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcccctcatccccaccccGcgccagagtacacaggccag	8	3	9	21	3	1	1	1	0	0	1	2	1	2	1	8	2	1	1	8	2	1	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr16:7568266G>A	uc002cys.2	+	5	1133	c.145G>A	c.(145-147)GCG>ACG	p.A49T	A2BP1_uc010buf.1_Missense_Mutation_p.A49T|A2BP1_uc002cyr.1_Missense_Mutation_p.A49T|A2BP1_uc002cyt.2_Missense_Mutation_p.A49T|A2BP1_uc010uxz.1_Missense_Mutation_p.A92T|A2BP1_uc010uya.1_Missense_Mutation_p.A85T|A2BP1_uc002cyv.1_Missense_Mutation_p.A49T|A2BP1_uc010uyb.1_Missense_Mutation_p.A49T|A2BP1_uc002cyw.2_Missense_Mutation_p.A69T|A2BP1_uc002cyy.2_Missense_Mutation_p.A69T|A2BP1_uc002cyx.2_Missense_Mutation_p.A69T|A2BP1_uc010uyc.1_Missense_Mutation_p.A69T	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	49					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TCCCCACCCCGCGCCAGAGTA	0.662													52	134					0	0	0	0	A	7568266	A	A	7568266	3	1	102	1	0	0	0	0	1	0	0	0	3	1087	38	1	242	1	A2BP1	16	7568266	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	4504795	7568266	82786487	101	19461											
ABCC1	4363	broad.mit.edu	37	chr16	16184309	16184309	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctacttgccgcaggtggaCgtcatcatcgtcatgagtgg	8	10	13	10	3	3	1	3	1	0	0	4	2	3	2	1	3	3	2	1	3	1	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr16:16184309C>T	uc010bvi.2	+	19	2683	c.2508C>T	c.(2506-2508)GAC>GAT	p.D836D	ABCC1_uc010bvj.2_Silent_p.D777D|ABCC1_uc010bvk.2_Silent_p.D780D|ABCC1_uc010bvl.2_Silent_p.D836D|ABCC1_uc010bvm.2_Silent_p.D721D|ABCC1_uc002del.3_Silent_p.D720D	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	836	ABC transporter 1.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CGCAGGTGGACGTCATCATCG	0.602													5	39					0	0	0	0	T	16184309	T	T	16184309	2	4	102	1	0	0	0	0	0	0	0	1	49	535	19	1		1	ABCC1	16	16184309	Silent	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	8616043	16184309	74170444	102	19462											
DNAH3	55567	broad.mit.edu	37	chr16	20999081	20999081	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaagtcccgcaggttaaaGacgtaatgtgacttcgaggg	12	8	14	7	3	0	3	0	1	0	2	2	5	1	3	1	2	0	3	1	2	4	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr16:20999081G>C	uc010vbe.1	-	46	6816	c.6816C>G	c.(6814-6816)GTC>GTG	p.V2272V	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2272	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCAGGTTAAAGACGTAATGTG	0.483													8	60					0	0	0	0	C	20999081	C	C	20999081	2	2	102	1	0	0	0	0	0	0	0	1	4625	929	33	2		2	DNAH3	16	20999081	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	4814772	20999081	69355672	103	19463											
SPN	6693	broad.mit.edu	37	chr16	29675887	29675887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcctgctgtggcgccggCggcagaagcggcggactggg	4	6	19	12	5	0	1	0	0	0	1	1	2	1	2	2	6	3	3	2	6	1	0			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr16:29675887C>T	uc002dtm.2	+	2	974	c.838C>T	c.(838-840)CGG>TGG	p.R280W	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Missense_Mutation_p.R280W|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	280	Cytoplasmic (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						GTGGCGCCGGCGGCAGAAGCG	0.687													6	27					0	0	0	0	T	29675887	T	T	29675887	3	4	102	1	0	0	0	0	1	0	0	0	15139	759	27	1	840	1	SPN	16	29675887	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	8676806	29675887	60678866	104	19464											
TP53	7157	broad.mit.edu	37	chr17	7577100	7577100	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctctgtgcgccggtctcTcccaggacaggcacaaacac	8	8	9	16	2	2	0	0	0	2	0	5	1	4	1	3	3	2	1	3	3	1	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr17:7577100T>C	uc002gim.2	-	8	1032	c.838A>G	c.(838-840)AGA>GGA	p.R280G	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280G|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148G|TP53_uc010cng.1_Missense_Mutation_p.R148G|TP53_uc002gii.1_Missense_Mutation_p.R148G|TP53_uc010cnh.1_Missense_Mutation_p.R280G|TP53_uc010cni.1_Missense_Mutation_p.R280G|TP53_uc002gij.2_Missense_Mutation_p.R280G	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.G279fs*65(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGCCGGTCTCTCCCAGGACAG	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	13					0	0	0	0	C	7577100	C	C	7577100	3	2	102	1	0	0	0	0	1	0	0	0	16448	1559	54	5	448	5	TP53	17	7577100	Missense_Mutation	SNP	T	TCGA-CQ-6220-01A-11D-1912-08		7577100	73618110	105	19465											
GUCY2D	3000	broad.mit.edu	37	chr17	7916484	7916484	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggagcgccggggaacgctggCcggcgacgtctttagcttgg	5	7	18	11	6	1	0	0	0	1	0	1	3	1	2	2	6	3	2	2	6	2	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr17:7916484C>T	uc002gjt.2	+	11	2251	c.2177C>T	c.(2176-2178)GCC>GTC	p.A726V		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	726	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				GGAACGCTGGCCGGCGACGTC	0.657													4	20					0	0	0	0	T	7916484	T	T	7916484	3	4	102	1	0	0	0	0	1	0	0	0	6936	739	26	4	2215	4	GUCY2D	17	7916484	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	339384	7916484	73278726	106	19466											
HAP1	9001	broad.mit.edu	37	chr17	39881315	39881315	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccgcaggcgtgaaatcttCcccccgcatgatatccgctg	7	9	9	16	4	1	2	0	2	1	0	4	2	4	2	5	1	0	3	5	1	2	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr17:39881315C>A	uc002hxm.1	-	12	1666	c.1654G>T	c.(1654-1656)GAA>TAA	p.E552*	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Nonsense_Mutation_p.E500*|HAP1_uc002hxo.1_Nonsense_Mutation_p.E483*|HAP1_uc002hxp.1_Nonsense_Mutation_p.E475*	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	552	Glu-rich.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			GTGAAATCTTCCCCCCGCATG	0.617													43	297					2.62258e-09	3.28235e-09	1	0	A	39881315	A	A	39881315	4	1	102	1	0	0	0	0	0	1	0	0	6992	864	30	2	365	2	HAP1	17	39881315	Nonsense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	31964831	39881315	41313895	107	19467											
GDPD1	284161	broad.mit.edu	37	chr17	57350187	57350187	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtttgaccacctaactgctcGaggcattcaagtaagtttct	10	13	8	10	1	2	1	1	1	1	0	3	2	2	1	2	1	2	5	2	1	3	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr17:57350187G>A	uc002ixk.1	+	9	949	c.812G>A	c.(811-813)CGA>CAA	p.R271Q	GDPD1_uc002ixj.2_Missense_Mutation_p.R271Q	NM_182569	NP_872375	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain	271	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					CTAACTGCTCGAGGCATTCAA	0.353													46	61					0	0	0	0	A	57350187	A	A	57350187	3	1	102	1	0	0	0	0	1	0	0	0	6360	1058	37	1	846	1	GDPD1	17	57350187	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	17468872	57350187	23845023	108	19468											
BCAS3	54828	broad.mit.edu	37	chr17	59112065	59112065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaaatttcacccagcaaatCgatgggcggagaattttgtg	13	10	10	8	2	1	1	1	0	0	1	2	3	1	1	1	2	1	1	1	2	3	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr17:59112065C>T	uc002iyv.3	+	18	1830	c.1721C>T	c.(1720-1722)TCG>TTG	p.S574L	BCAS3_uc010wow.1_Missense_Mutation_p.S346L|BCAS3_uc002iyu.3_Missense_Mutation_p.S559L|BCAS3_uc002iyw.3_Missense_Mutation_p.S555L|BCAS3_uc002iyy.3_Missense_Mutation_p.S330L|BCAS3_uc002iyz.3_Missense_Mutation_p.S128L|BCAS3_uc002iza.3_Missense_Mutation_p.S113L	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	574						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			CCCAGCAAATCGATGGGCGGA	0.348													16	55					0	0	0	0	T	59112065	T	T	59112065	3	4	102	1	0	0	0	0	1	0	0	0	1354	893	31	1	1787	1	BCAS3	17	59112065	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	1761878	59112065	22083145	109	19469											
SRP68	6730	broad.mit.edu	37	chr17	74060213	74060213	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttcagctgcatggcgtagctCcaggctctttcagcatccat	7	12	9	13	1	3	0	2	0	1	0	5	0	5	0	2	2	4	6	2	2	1	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr17:74060213C>G	uc002jqk.1	-	4	440	c.405G>C	c.(403-405)TGG>TGC	p.W135C	SRP68_uc010wsu.1_Missense_Mutation_p.W34C|SRP68_uc002jql.1_Missense_Mutation_p.W97C	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	135					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						TGGCGTAGCTCCAGGCTCTTT	0.493													16	130					0	0	0	0	G	74060213	G	G	74060213	3	3	102	1	0	0	0	0	1	0	0	0	15222	856	30	2	1530	2	SRP68	17	74060213	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	14948148	74060213	7134997	110	19470											
CBX4	8535	broad.mit.edu	37	chr17	77808429	77808429	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccggcatcctggggctgcgGatcgctaaccccggacacct	6	6	13	16	4	0	0	0	0	0	0	2	2	1	2	5	5	2	3	5	5	1	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr17:77808429G>A	uc002jxe.2	-	5	1175	c.1012C>T	c.(1012-1014)CCG>TCG	p.P338S		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	338	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TGGGGCTGCGGATCGCTAACC	0.662											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	39					0	0	0	0	A	77808429	A	A	77808429	3	1	102	1	0	0	0	0	1	0	0	0	2732	1174	41	2	674	2	CBX4	17	77808429	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	3748216	77808429	3386781	111	19471											
CBX4	8535	broad.mit.edu	37	chr17	77808470	77808470	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctcctccctcctcttgggcGgcgcctccaccttcttctcc	1	12	6	22	2	3	0	0	0	3	0	8	0	7	0	8	2	0	0	8	2	0	3	rs150413647		TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr17:77808470G>A	uc002jxe.2	-	5	1134	c.971C>T	c.(970-972)CCG>CTG	p.P324L		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	324	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity	p.P324L(1)|p.P324S(1)		skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CCTCTTGGGCGGCGCCTCCAC	0.672											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	54					0	0	0	0	A	77808470	A	A	77808470	3	1	102	1	0	0	0	0	1	0	0	0	2732	1116	39	1	715	1	CBX4	17	77808470	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	41	77808470	3386740	112	19472											
CABYR	26256	broad.mit.edu	37	chr18	21723218	21723218	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttcaagaacttactatgtAtagaggtttgttattccttt	10	20	6	5	0	1	2	1	0	0	2	2	2	2	2	1	1	2	3	1	1	7	10			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr18:21723218A>G	uc002kux.2	+	2	292	c.140A>G	c.(139-141)TAT>TGT	p.Y47C	CABYR_uc010xbb.1_Intron|CABYR_uc002kuy.2_Missense_Mutation_p.Y47C|CABYR_uc002kuz.2_Missense_Mutation_p.Y47C|CABYR_uc002kva.2_Missense_Mutation_p.Y47C|CABYR_uc002kvb.2_Intron|CABYR_uc002kvc.2_Missense_Mutation_p.Y47C	NM_012189	NP_036321	O75952	CABYR_HUMAN	calcium-binding tyrosine	47	RIIa.				ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding				0	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					CTTACTATGTATAGAGGTTTG	0.343													7	28					0	0	0	0	G	21723218	G	G	21723218	3	3	102	1	0	0	0	0	1	0	0	0	2548	449	16	5	142	5	CABYR	18	21723218	Missense_Mutation	SNP	A	TCGA-CQ-6220-01A-11D-1912-08		21723218	56354030	113	19473											
TCF4	6925	broad.mit.edu	37	chr18	52896157	52896157	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtctggggcttgtcactCttgaggtggagctgcaccat	5	13	14	9	0	3	1	1	1	2	0	3	2	3	2	1	5	2	3	1	5	0	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr18:52896157C>G	uc002lfz.2	-	18	2400	c.1788G>C	c.(1786-1788)AAG>AAC	p.K596N	TCF4_uc002lfw.3_Missense_Mutation_p.K440N|TCF4_uc010xdu.1_Missense_Mutation_p.K466N|TCF4_uc010xdv.1_Missense_Mutation_p.K466N|TCF4_uc002lfx.2_Missense_Mutation_p.K529N|TCF4_uc010xdw.1_Missense_Mutation_p.K466N|TCF4_uc002lfy.2_Missense_Mutation_p.K554N|TCF4_uc010xdx.1_Missense_Mutation_p.K572N|TCF4_uc010dph.1_Missense_Mutation_p.K600N|TCF4_uc010xdy.1_Missense_Mutation_p.K576N|TCF4_uc002lga.2_Missense_Mutation_p.K702N|TCF4_uc002lgb.1_Missense_Mutation_p.K436N|TCF4_uc010dpi.2_Missense_Mutation_p.K606N|TCF4_uc002lfv.2_Missense_Mutation_p.K379N	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	596	Helix-loop-helix motif.				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		GCTTGTCACTCTTGAGGTGGA	0.622													21	83					0	0	0	0	G	52896157	G	G	52896157	3	3	102	1	0	0	0	0	1	0	0	0	15761	912	32	2	223	2	TCF4	18	52896157	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	31172939	52896157	25181091	114	19474											
ILVBL	10994	broad.mit.edu	37	chr19	15226688	15226688	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgacgaatgtatcaaattcGatgaggctgtagccaaaagc	14	9	10	8	2	1	2	1	2	0	0	2	4	1	2	1	1	2	3	1	1	6	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr19:15226688G>A	uc002nam.2	-	14	1708	c.1587C>T	c.(1585-1587)ATC>ATT	p.I529I	ILVBL_uc010xof.1_Silent_p.I170I|ILVBL_uc010dzw.2_Silent_p.I422I	NM_006844	NP_006835	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	529	Thiamine pyrophosphate binding (By similarity).					integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			ovary(2)	2						TATCAAATTCGATGAGGCTGT	0.582													17	29					0	0	0	0	A	15226688	A	A	15226688	2	1	102	1	0	0	0	0	0	0	0	1	7754	1048	37	1		1	ILVBL	19	15226688	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		15226688	43902295	115	19475											
CPAMD8	27151	broad.mit.edu	37	chr19	17010309	17010309	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaaagtagaagagcactcGgcgtccagccacttcatacc	13	7	8	13	2	2	2	2	0	0	2	4	2	3	2	3	1	3	2	3	1	4	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr19:17010309G>A	uc002nfb.2	-	37	4998	c.4966C>T	c.(4966-4968)CGA>TGA	p.R1656*	CPAMD8_uc010xpj.1_5'Flank|CPAMD8_uc002nfd.1_Nonsense_Mutation_p.R121*	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1609						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						AAGAGCACTCGGCGTCCAGCC	0.577													7	48					0	0	0	0	A	17010309	A	A	17010309	4	1	102	1	0	0	0	0	0	1	0	0	3810	1124	39	1	856	1	CPAMD8	19	17010309	Nonsense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	1783621	17010309	42118674	116	19476											
MAST3	23031	broad.mit.edu	37	chr19	18232697	18232697	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatagtcctcggaatttctcGgctgcctctgccctaaattt	7	14	8	12	2	2	0	0	0	2	0	5	2	3	1	3	2	2	1	3	2	4	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr19:18232697G>A	uc002nhz.3	+	4	198	c.198G>A	c.(196-198)TCG>TCA	p.S66S		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	66							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						GGAATTTCTCGGCTGCCTCTG	0.642													12	40					0	0	0	0	A	18232697	A	A	18232697	2	1	102	1	0	0	0	0	0	0	0	1	9379	1103	39	1		1	MAST3	19	18232697	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	1222388	18232697	40896286	117	19477											
ZFP112	7771	broad.mit.edu	37	chr19	44901376	44901376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taacttacctggaacttaatCataccgtcttccttttggaa	11	15	5	10	1	2	0	1	0	1	0	3	2	3	2	3	2	4	0	3	2	6	7			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr19:44901376C>T	uc010xwz.1	-	2	90	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ZNF285_uc010xxa.1_Missense_Mutation_p.M1I|ZNF285_uc002ozd.3_Missense_Mutation_p.M1I	NM_013380	NP_037512	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 2	1					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						GGAACTTAATCATACCGTCTT	0.373													8	161					0	0	0	0	T	44901376	T	T	44901376	3	4	102	1	0	0	0	0	1	0	0	0	17705	826	29	2		2	ZFP112	19	44901376	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	26668679	44901376	14227607	118	19478											
SHANK1	50944	broad.mit.edu	37	chr19	51218989	51218989	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgggtcttgtatcggaacTgaggtcaagggtagggtagt	8	11	16	6	2	2	1	1	1	1	0	4	2	2	2	0	5	1	3	0	5	5	4			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr19:51218989T>A	uc002psx.1	-	3	479	c.460_splice	c.e3-1	p.F154_splice		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1						cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GTATCGGAACTGAGGTCAAGG	0.532													58	70					0	0	0	0	A	51218989	A	A	51218989	5	1	102	1	0	0	0	0	0	0	1	0	14329	1594	55	5	6111	5	SHANK1	19	51218989	Splice_Site	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	6317613	51218989	7909994	119	19479											
NLRP2	55655	broad.mit.edu	37	chr19	55493937	55493937	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttcgtgattgacggctttGatgagctgggagccgcacct	6	12	14	9	3	0	4	0	4	0	0	1	5	0	5	2	2	2	4	2	2	0	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr19:55493937G>C	uc002qij.2	+	6	957	c.871G>C	c.(871-873)GAT>CAT	p.D291H	NLRP2_uc010yfp.1_Missense_Mutation_p.D268H|NLRP2_uc010esn.2_Missense_Mutation_p.D267H|NLRP2_uc010eso.2_Missense_Mutation_p.D288H|NLRP2_uc010esp.2_Missense_Mutation_p.D269H	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	291	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		TGACGGCTTTGATGAGCTGGG	0.567													7	72					0	0	0	0	C	55493937	C	C	55493937	3	2	102	1	0	0	0	0	1	0	0	0	10531	1290	45	2	889	2	NLRP2	19	55493937	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	4274948	55493937	3635046	120	19480											
ZNF418	147686	broad.mit.edu	37	chr19	58438123	58438123	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatggcctttctccagtgtGaactctctggtgttcaatga	8	15	9	9	0	3	2	1	2	2	0	5	2	3	2	2	2	1	1	2	2	3	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr19:58438123G>C	uc002qqs.1	-	4	1718	c.1426C>G	c.(1426-1428)CAC>GAC	p.H476D	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.H391D	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	476	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TCTCCAGTGTGAACTCTCTGG	0.448													49	80					0	0	0	0	C	58438123	C	C	58438123	3	2	102	1	0	0	0	0	1	0	0	0	17962	1290	45	2	608	2	ZNF418	19	58438123	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	2944186	58438123	690860	121	19481											
SLC4A11	83959	broad.mit.edu	37	chr20	3211607	3211607	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtctgtgttctcgtcattGagagacccgaaagcgatggt	8	11	12	10	4	3	2	1	1	2	1	4	5	3	2	2	1	1	1	2	1	1	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr20:3211607G>A	uc002wig.2	-	9	1236	c.1188C>T	c.(1186-1188)CTC>CTT	p.L396L	SLC4A11_uc010zqe.1_Silent_p.L423L|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Silent_p.L380L	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	396	Helical; (Potential).|Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						TCTCGTCATTGAGAGACCCGA	0.627													11	101					0	0	0	0	A	3211607	A	A	3211607	2	1	102	1	0	0	0	0	0	0	0	1	14716	1277	45	2		2	SLC4A11	20	3211607	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		3211607	59813913	122	19482											
CENPB	1059	broad.mit.edu	37	chr20	3766629	3766629	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcgccaaccagtagtgcTcccgccactgccctccgagg	7	5	11	18	4	0	0	0	0	0	0	2	1	2	0	6	1	4	2	6	1	2	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr20:3766629T>C	uc002wjk.2	-	1	709	c.502A>G	c.(502-504)AGC>GGC	p.S168G	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	168					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						CCAGTAGTGCTCCCGCCACTG	0.756													2	4					0	0	0	0	C	3766629	C	C	3766629	3	2	102	1	0	0	0	0	1	0	0	0	3242	1551	54	5	1301	5	CENPB	20	3766629	Missense_Mutation	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	555022	3766629	59258891	123	19483											
ESF1	51575	broad.mit.edu	37	chr20	13763716	13763716	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgatccttttctggcattTcccaaaatctcgggtccttt	6	17	6	12	2	2	0	0	0	2	0	7	1	5	0	3	2	0	1	3	2	2	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr20:13763716T>G	uc002woj.2	-	2	179	c.71A>C	c.(70-72)GAA>GCA	p.E24A	ESF1_uc002wok.1_Missense_Mutation_p.E24A|C20orf7_uc002wol.1_5'Flank|C20orf7_uc002wom.2_5'Flank|C20orf7_uc002won.2_5'Flank|C20orf7_uc002woo.2_5'Flank	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						TTCTGGCATTTCCCAAAATCT	0.398													14	77					0	0	0	0	G	13763716	G	G	13763716	3	3	102	1	0	0	0	0	1	0	0	0	5275	1783	62	5	2536	5	ESF1	20	13763716	Missense_Mutation	SNP	T	TCGA-CQ-6220-01A-11D-1912-08	9997087	13763716	49261804	124	19484											
MYH7B	57644	broad.mit.edu	37	chr20	33582110	33582110	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcgggggttgcgaggggCgctggctgcggccgaggcca	3	5	22	11	5	0	0	0	0	0	0	0	2	0	0	2	7	3	4	2	7	0	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr20:33582110C>T	uc002xbi.1	+	25	2824	c.2732C>T	c.(2731-2733)GCG>GTG	p.A911V		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	869	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TTGCGAGGGGCGCTGGCTGCG	0.662													12	186					0	0	0	0	T	33582110	T	T	33582110	3	4	102	1	0	0	0	0	1	0	0	0	10093	768	27	1	2830	1	MYH7B	20	33582110	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	19818394	33582110	29443410	125	19485											
SULF2	55959	broad.mit.edu	37	chr20	46386015	46386015	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccctctgaaacctgcctttCaggcggtggtgcgacaggaa	8	9	12	12	2	2	1	1	1	1	0	3	3	3	2	3	4	3	0	3	4	2	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr20:46386015C>G	uc002xto.2	-	2	423	c.93G>C	c.(91-93)CTG>CTC	p.L31L	SULF2_uc002xtr.2_Silent_p.L31L|SULF2_uc002xtq.2_Silent_p.L31L|SULF2_uc010ghv.1_Silent_p.L31L	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	31					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						ACCTGCCTTTCAGGCGGTGGT	0.627													9	10					0	0	0	0	G	46386015	G	G	46386015	2	3	102	1	0	0	0	0	0	0	0	1	15437	813	29	2		2	SULF2	20	46386015	Silent	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	12803905	46386015	16639505	126	19486											
PRIC285	85441	broad.mit.edu	37	chr20	62198219	62198219	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcaccgtgggaaacgacaCagatgcacctctgctcgcgg	9	5	14	13	4	1	1	0	0	1	1	2	3	1	2	2	3	3	3	2	3	1	0			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr20:62198219C>G	uc002yfm.2	-	7	3384	c.2492G>C	c.(2491-2493)TGT>TCT	p.C831S	PRIC285_uc002yfl.1_Missense_Mutation_p.C262S	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	831					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GGAAACGACACAGATGCACCT	0.692													10	68					0	0	0	0	G	62198219	G	G	62198219	3	3	102	1	0	0	0	0	1	0	0	0	12547	478	17	4	5513	4	PRIC285	20	62198219	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	15812204	62198219	827301	127	19487											
GGT5	2687	broad.mit.edu	37	chr22	24621019	24621019	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgctgttgacatgcaggatgGgggctgcaatggccgctctc	6	10	15	10	1	1	1	0	1	1	0	2	2	1	2	1	4	3	6	1	4	1	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr22:24621019G>A	uc002zzo.3	-	11	1976	c.1559C>T	c.(1558-1560)CCC>CTC	p.P520L	GGT5_uc002zzp.3_Missense_Mutation_p.P521L|GGT5_uc002zzr.3_Missense_Mutation_p.P488L|GGT5_uc002zzq.3_Missense_Mutation_p.P488L|GGT5_uc011ajm.1_Missense_Mutation_p.P444L	NM_004121	NP_004112	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5 isoform b	520	Extracellular (Potential).				glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(2)|skin(1)	3						ATGCAGGATGGGGGCTGCAAT	0.612													3	8					0	0	0	0	A	24621019	A	A	24621019	3	1	102	1	0	0	0	0	1	0	0	0	6399	1232	43	4	209	4	GGT5	22	24621019	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		24621019	26683547	128	19488											
ZNRF3	84133	broad.mit.edu	37	chr22	29446049	29446049	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgccctgtgcttcgagggctCcccgcctcccgaggagctcc	3	8	12	18	3	0	0	0	0	0	0	4	3	3	1	6	2	3	3	6	2	0	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr22:29446049C>G	uc003aeg.2	+	8	1745	c.1580C>G	c.(1579-1581)TCC>TGC	p.S527C	ZNRF3_uc003aeh.1_Missense_Mutation_p.S527C	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	627	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						TTCGAGGGCTCCCCGCCTCCC	0.731													19	40					0	0	0	0	G	29446049	G	G	29446049	3	3	102	1	0	0	0	0	1	0	0	0	18280	855	30	2	1606	2	ZNRF3	22	29446049	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	4825030	29446049	21858517	129	19489											
APOBEC3H	164668	broad.mit.edu	37	chr22	39497291	39497291	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taacgagatcaagtccatggGactggacgaaacgcagtgct	13	7	12	9	3	1	1	1	0	0	1	2	5	2	3	1	2	3	2	1	2	3	1			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr22:39497291G>A	uc011aoh.1	+	3	266	c.200G>A	c.(199-201)GGA>GAA	p.G67E	APOBEC3H_uc011aoi.1_5'Flank|APOBEC3H_uc003axa.3_5'Flank	NM_181773	NP_861438	Q6NTF7	ABC3H_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	67					DNA cytosine deamination|negative regulation of retroviral genome replication|negative regulation of transposition	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Melanoma(58;0.04)					AAGTCCATGGGACTGGACGAA	0.542													24	60					0	0	0	0	A	39497291	A	A	39497291	3	1	102	1	0	0	0	0	1	0	0	0	795	1174	41	2	206	2	APOBEC3H	22	39497291	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	10051242	39497291	11807275	130	19490											
HDAC10	83933	broad.mit.edu	37	chr22	50687866	50687866	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccatgctcatagcggtgcCaggagaagtaaaggacgctg	11	6	14	10	2	1	1	1	0	0	1	1	3	1	2	2	3	3	3	2	3	4	2			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chr22:50687866C>T	uc003bkg.2	-	7	954	c.581G>A	c.(580-582)TGG>TAG	p.W194*	HDAC10_uc003bke.2_5'UTR|HDAC10_uc003bkf.2_5'UTR|HDAC10_uc010hav.2_Nonsense_Mutation_p.W194*|HDAC10_uc003bkh.2_Missense_Mutation_p.G23S|HDAC10_uc003bki.2_Nonsense_Mutation_p.W194*|HDAC10_uc003bkj.2_Intron|HDAC10_uc003bkk.1_5'Flank	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	194	Histone deacetylase.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ATAGCGGTGCCAGGAGAAGTA	0.617													4	46					0	0	0	0	T	50687866	T	T	50687866	4	4	102	1	0	0	0	0	0	1	0	0	7044	595	21	4	1484	4	HDAC10	22	50687866	Nonsense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	11190575	50687866	616700	131	19491											
PPP2R3B	28227	broad.mit.edu	37	chrX	295163	295163	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaggtccacggcgcccagcGgtgagggcgcctcgaagaag	9	3	16	13	5	0	2	0	1	0	1	2	3	1	2	3	4	1	0	3	4	2	0	rs143642265	byFrequency	TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chrX:295163G>A	uc004cpg.2	-	13	1868	c.1667C>T	c.(1666-1668)CCG>CTG	p.P556L	PPP2R3B_uc004cpf.2_Missense_Mutation_p.P157L	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	556					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCGCCCAGCGGTGAGGGCGC	0.726													6	42					0	0	0	0	A	295163	A	A	295163	3	1	102	1	0	0	0	0	1	0	0	0	12449	1116	39	1	64	1	PPP2R3B	23	295163	Missense_Mutation	SNP	G	TCGA-CQ-6220-01A-11D-1912-08		295163	154975397	132	19492											
DIAPH2	1730	broad.mit.edu	37	chrX	96136646	96136646	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgttcatgaattacgatcGggtatatcagatgagaaact	14	13	9	5	2	2	3	2	2	0	2	3	5	2	3	0	1	2	2	0	1	6	5			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chrX:96136646G>C	uc004efu.3	+	5	912	c.516G>C	c.(514-516)TCG>TCC	p.S172S	DIAPH2_uc004eft.3_Silent_p.S172S|DIAPH2_uc004efs.2_Silent_p.S179S|RPA4_uc004efv.3_5'Flank	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	172	GBD/FH3.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						AATTACGATCGGGTATATCAG	0.383													15	14					0	0	0	0	C	96136646	C	C	96136646	2	2	102	1	0	0	0	0	0	0	0	1	4541	1103	39	3		3	DIAPH2	23	96136646	Silent	SNP	G	TCGA-CQ-6220-01A-11D-1912-08	95841483	96136646	59133914	133	19493											
AIFM1	9131	broad.mit.edu	37	chrX	129281541	129281541	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcatctgaaaaccacagttCttttgaaagaggaggtcgca	13	10	10	8	1	3	3	1	2	2	1	4	4	3	4	1	2	1	2	1	2	3	3			TCGA-CQ-6220-01A-11D-1912-08	TCGA-CQ-6220-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e67eda-16a4-4dfd-94a9-546c76d94a02	7a2a9850-af1f-4b45-a5da-5d1952c42558	g.chrX:129281541C>G	uc004evg.2	-	5	710	c.532G>C	c.(532-534)GAA>CAA	p.E178Q	AIFM1_uc011mus.1_Missense_Mutation_p.E178Q|AIFM1_uc004evh.2_Missense_Mutation_p.E174Q|AIFM1_uc004evi.2_Intron|AIFM1_uc004evk.2_RNA	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	178	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5						AACCACAGTTCTTTTGAAAGA	0.413													20	51					0	0	0	0	G	129281541	G	G	129281541	3	3	102	1	0	0	0	0	1	0	0	0	426	922	32	2	1369	2	AIFM1	23	129281541	Missense_Mutation	SNP	C	TCGA-CQ-6220-01A-11D-1912-08	33144895	129281541	25989019	134	19494											
PLEKHN1	84069	broad.mit.edu	37	chr1	906212	906212	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggggcctgccctgtggctGcggagcacgtgtgtgtatgt	4	10	18	9	2	0	0	0	0	0	0	0	2	0	1	2	4	3	3	2	4	1	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:906212G>T	uc001ace.2	+	5	593	c.558G>T	c.(556-558)CTG>CTT	p.L186L	PLEKHN1_uc001acd.2_Intron|PLEKHN1_uc001acf.2_Intron	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	186	PH 1.										0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CCCTGTGGCTGCGGAGCACGT	0.692													13	23					9.31168e-06	1.02233e-05	1	0	T	906212	T	T	906212	2	4	103	1	0	0	0	0	0	0	0	1	12138	1334	46	4		4	PLEKHN1	1	906212	Silent	SNP	G	TCGA-CQ-6221-01A-11D-2078-08		906212	248344409	1	19495											
CHD5	26038	broad.mit.edu	37	chr1	6209356	6209356	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agccttctccagctctgggtCcaggcatacgagatggtagg	8	9	13	11	1	2	1	0	0	2	1	4	2	3	1	3	4	3	3	3	4	2	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:6209356C>G	uc001amb.1	-	8	1211	c.1111G>C	c.(1111-1113)GAC>CAC	p.D371H	CHD5_uc001amc.1_5'Flank	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	371	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AGCTCTGGGTCCAGGCATACG	0.657													3	21					0	0	0	0	G	6209356	G	G	6209356	3	3	103	1	0	0	0	0	1	0	0	0	3343	855	30	2	4889	2	CHD5	1	6209356	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	5303144	6209356	243041265	2	19496											
CAMTA1	23261	broad.mit.edu	37	chr1	7724545	7724545	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcaccttcgtgatgcccacGgtgaaaacggaggcctcgtc	8	7	13	13	4	0	2	0	2	0	0	3	3	0	3	3	4	2	1	3	4	2	1	rs142993717		TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:7724545G>C	uc001aoi.2	+	9	2145	c.1938G>C	c.(1936-1938)ACG>ACC	p.T646T		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TGATGCCCACGGTGAAAACGG	0.637													54	167					0	0	0	0	C	7724545	C	C	7724545	2	2	103	1	0	0	0	0	0	0	0	1	2625	1103	39	3		3	CAMTA1	1	7724545	Silent	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	1515189	7724545	241526076	3	19497											
KIF1B	23095	broad.mit.edu	37	chr1	10318626	10318626	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgctcttacacgcctttGagggatataatgtctgtatt	11	15	8	7	1	2	1	0	1	2	0	2	2	2	2	1	1	2	2	1	1	5	6			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:10318626G>C	uc001aqx.3	+	4	461	c.259G>C	c.(259-261)GAG>CAG	p.E87Q	KIF1B_uc001aqv.3_Missense_Mutation_p.E87Q|KIF1B_uc001aqw.3_Missense_Mutation_p.E87Q|KIF1B_uc001aqy.2_Missense_Mutation_p.E87Q|KIF1B_uc001aqz.2_Missense_Mutation_p.E87Q|KIF1B_uc001ara.2_Missense_Mutation_p.E87Q|KIF1B_uc001arb.2_Missense_Mutation_p.E87Q|KIF1B_uc009vmt.2_RNA	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	87	Kinesin-motor.			E -> G (in Ref. 7; BAA25517).	anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ACACGCCTTTGAGGGATATAA	0.418													21	47					0	0	0	0	C	10318626	C	C	10318626	3	2	103	1	0	0	0	0	1	0	0	0	8323	1291	45	2	269	2	KIF1B	1	10318626	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	2594081	10318626	238931995	4	19498											
VPS13D	55187	broad.mit.edu	37	chr1	12443180	12443180	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctggaatgttatccatcaGagtcatcccagatggaccaa	12	11	8	10	0	3	2	2	0	1	2	5	4	5	4	3	2	0	1	3	2	3	2	rs140461198		TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:12443180G>C	uc001atv.2	+	58	11477	c.11336G>C	c.(11335-11337)AGA>ACA	p.R3779T	VPS13D_uc001atw.2_Missense_Mutation_p.R3754T|VPS13D_uc001atx.2_Missense_Mutation_p.R2966T|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3778					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTATCCATCAGAGTCATCCCA	0.433													9	45					0	0	0	0	C	12443180	C	C	12443180	3	2	103	1	0	0	0	0	1	0	0	0	17260	942	33	2	11562	2	VPS13D	1	12443180	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	2124554	12443180	236807441	5	19499											
HTR6	3362	broad.mit.edu	37	chr1	19992252	19992252	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaccctcggtcctcatggtCccagagccgggcccaaccgc	6	5	10	20	3	1	1	1	0	0	1	4	1	3	1	7	3	2	0	7	3	1	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:19992252C>A	uc001bcl.2	+	1	473	c.6C>A	c.(4-6)GTC>GTA	p.V2V		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	2	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	TCCTCATGGTCCCAGAGCCGG	0.468													4	13					0.00024832	0.000261653	1	0	A	19992252	A	A	19992252	2	1	103	1	0	0	0	0	0	0	0	1	7490	842	30	2		2	HTR6	1	19992252	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	7549072	19992252	229258369	6	19500											
C1orf201	90529	broad.mit.edu	37	chr1	24706250	24706250	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtctctcttggaaataaaatCcgatgggatagtgtatgcat	12	13	10	6	1	2	0	0	0	2	0	4	3	3	2	1	2	1	2	1	2	5	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:24706250C>G	uc001bjc.2	-	5	490	c.355G>C	c.(355-357)GAT>CAT	p.D119H	C1orf201_uc001bja.2_Missense_Mutation_p.D72H|C1orf201_uc001bjb.2_Missense_Mutation_p.D27H|C1orf201_uc001bjd.2_Missense_Mutation_p.D119H|C1orf201_uc001bje.1_Missense_Mutation_p.D72H|C1orf201_uc001bjf.2_5'UTR			Q5TH74	CA201_HUMAN	RecName: Full=UPF0490 protein C1orf201;	119										ovary(1)|breast(1)	2		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.0191)|all_lung(284;0.0251)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.056)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.48e-25)|Colorectal(126;7.29e-08)|COAD - Colon adenocarcinoma(152;3.85e-06)|GBM - Glioblastoma multiforme(114;0.000399)|BRCA - Breast invasive adenocarcinoma(304;0.00107)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00393)|READ - Rectum adenocarcinoma(331;0.0672)|Lung(427;0.145)		GAAATAAAATCCGATGGGATA	0.428													6	35					0	0	0	0	G	24706250	G	G	24706250	3	3	103	1	0	0	0	0	1	0	0	0	2036	855	30	2	669	2	C1orf201	1	24706250	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	4713998	24706250	224544371	7	19501											
GRIK3	2899	broad.mit.edu	37	chr1	37291332	37291332	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccattgggctttcgatacagGatgctcacaccaagtgtcat	10	11	9	11	1	2	0	2	0	0	0	3	2	2	1	2	2	2	2	2	2	2	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:37291332G>T	uc001caz.2	-	11	1761	c.1626C>A	c.(1624-1626)ATC>ATA	p.I542I	GRIK3_uc001cba.1_Silent_p.I542I	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	542	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TTCGATACAGGATGCTCACAC	0.572													22	34					1.28384e-07	1.45009e-07	1	0	T	37291332	T	T	37291332	2	4	103	1	0	0	0	0	0	0	0	1	6814	1164	41	2		2	GRIK3	1	37291332	Silent	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	12585082	37291332	211959289	8	19502											
MTF1	4520	broad.mit.edu	37	chr1	38280845	38280845	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgaggcccatctcctccTccccctgcagtagtgcttca	5	11	9	16	0	2	1	1	1	1	0	5	1	4	1	5	2	2	3	5	2	1	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:38280845T>C	uc001cce.1	-	11	2366	c.2225A>G	c.(2224-2226)GAG>GGG	p.E742G		NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	742						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CATCTCCTCCTCCCCCTGCAG	0.547													7	77					0	0	0	0	C	38280845	C	C	38280845	3	2	103	1	0	0	0	0	1	0	0	0	9975	1551	54	5	40	5	MTF1	1	38280845	Missense_Mutation	SNP	T	TCGA-CQ-6221-01A-11D-2078-08	989513	38280845	210969776	9	19503											
KIAA0494	9813	broad.mit.edu	37	chr1	47183657	47183657	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagtctgagtcgggaggctCagtgcgaagcaggcggtgac	9	6	18	8	3	2	3	1	2	1	1	3	5	2	4	0	4	2	2	0	4	1	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:47183657C>G	uc001cqk.3	-	1	1080	c.103G>C	c.(103-105)GAG>CAG	p.E35Q	KIAA0494_uc010omh.1_Missense_Mutation_p.E35Q|KIAA0494_uc001cql.1_Missense_Mutation_p.E35Q	NM_014774	NP_055589	O75071	K0494_HUMAN	hypothetical protein LOC9813	35							calcium ion binding				0	Acute lymphoblastic leukemia(166;0.155)					TCGGGAGGCTCAGTGCGAAGC	0.542													20	49					0	0	0	0	G	47183657	G	G	47183657	3	3	103	1	0	0	0	0	1	0	0	0	8218	835	29	2	1428	2	KIAA0494	1	47183657	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	8902812	47183657	202066964	10	19504											
GBP7	388646	broad.mit.edu	37	chr1	89616257	89616257	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttggatttggggattcttGcctgcagaattagtgaaaaa	11	15	11	4	0	1	2	0	1	1	1	1	4	1	4	1	3	2	1	1	3	4	6			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:89616257G>A	uc001dna.2	-	6	766	c.627C>T	c.(625-627)GGC>GGT	p.G209G	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	209						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		GGGGATTCTTGCCTGCAGAAT	0.403													11	67					0	0	0	0	A	89616257	A	A	89616257	2	1	103	1	0	0	0	0	0	0	0	1	6314	1333	46	4		4	GBP7	1	89616257	Silent	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	42432600	89616257	159634364	11	19505											
CELSR2	1952	broad.mit.edu	37	chr1	109810498	109810498	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggctacagcggaatgagtCaggcctagactcagggcgct	9	6	15	11	3	2	2	2	1	0	1	2	3	2	3	1	4	2	2	1	4	3	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:109810498C>G	uc001dxa.3	+	17	6195	c.6134C>G	c.(6133-6135)TCA>TGA	p.S2045*		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2045	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CGGAATGAGTCAGGCCTAGAC	0.632													3	31					0	0	0	0	G	109810498	G	G	109810498	4	3	103	1	0	0	0	0	0	1	0	0	3237	838	29	2	6200	2	CELSR2	1	109810498	Nonsense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	20194241	109810498	139440123	12	19506											
SORT1	6272	broad.mit.edu	37	chr1	109897086	109897086	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtttgcacaaaattcttcGcaaaatctgatgatctaaag	14	13	6	8	1	3	2	0	2	3	0	4	2	3	2	0	0	1	3	0	0	6	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:109897086G>A	uc001dxm.1	-	5	660	c.611C>T	c.(610-612)GCG>GTG	p.A204V	SORT1_uc010ovi.1_Missense_Mutation_p.A68V|SORT1_uc009wfb.2_Missense_Mutation_p.A68V	NM_002959	NP_002950	Q99523	SORT_HUMAN	sortilin 1 preproprotein	204	Extracellular (Potential).|BNR 2.				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		AAAATTCTTCGCAAAATCTGA	0.418													30	77					0	0	0	0	A	109897086	A	A	109897086	3	1	103	1	0	0	0	0	1	0	0	0	14999	1087	38	1	1948	1	SORT1	1	109897086	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	86588	109897086	139353535	13	19507											
ATP8B2	57198	broad.mit.edu	37	chr1	154306629	154306629	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacaaactggacaaattcagCggaaccctctactggaagga	16	6	9	10	1	2	0	1	0	1	0	2	4	2	4	1	4	5	0	1	4	6	2	rs142408071	by1000genomes	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:154306629C>T	uc001fey.1	+	9	882	c.693C>T	c.(691-693)AGC>AGT	p.S231S	ATP8B2_uc001few.2_Silent_p.S212S|ATP8B2_uc001fex.2_Silent_p.S245S	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	231	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACAAATTCAGCGGAACCCTCT	0.517													104	167					0	0	0	0	T	154306629	T	T	154306629	2	4	103	1	0	0	0	0	0	0	0	1	1197	767	27	1		1	ATP8B2	1	154306629	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	44409543	154306629	94943992	14	19508											
PIK3C2B	5287	broad.mit.edu	37	chr1	204413526	204413526	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccaatccactgcacagccAtacgacgcacctcctggtcc	10	6	7	18	2	0	0	0	0	0	0	3	1	3	0	6	1	4	2	6	1	2	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:204413526A>T	uc001haw.2	-	18	3184	c.2705T>A	c.(2704-2706)ATG>AAG	p.M902K	PIK3C2B_uc010pqv.1_Missense_Mutation_p.M874K	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	902					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			CTGCACAGCCATACGACGCAC	0.587													4	15					0	0	0	0	T	204413526	T	T	204413526	3	4	103	1	0	0	0	0	1	0	0	0	11965	217	8	5	2267	5	PIK3C2B	1	204413526	Missense_Mutation	SNP	A	TCGA-CQ-6221-01A-11D-2078-08	50106897	204413526	44837095	15	19509											
NLRP3	114548	broad.mit.edu	37	chr1	247587937	247587937	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagccagggcagccttcagtCtgattcaggagaacgaggtc	11	7	13	10	1	3	2	2	1	1	1	4	4	3	2	2	3	3	1	2	3	2	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:247587937C>G	uc001icr.2	+	5	1330	c.1192C>G	c.(1192-1194)CTG>GTG	p.L398V	NLRP3_uc001ics.2_Missense_Mutation_p.L398V|NLRP3_uc001icu.2_Missense_Mutation_p.L398V|NLRP3_uc001icw.2_Missense_Mutation_p.L398V|NLRP3_uc001icv.2_Missense_Mutation_p.L398V|NLRP3_uc010pyw.1_Missense_Mutation_p.L396V|NLRP3_uc001ict.1_Missense_Mutation_p.L396V	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	398	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGCCTTCAGTCTGATTCAGGA	0.537													23	42					0	0	0	0	G	247587937	G	G	247587937	3	3	103	1	0	0	0	0	1	0	0	0	10532	912	32	2	1202	2	NLRP3	1	247587937	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	43174411	247587937	1662684	16	19510											
ADAM17	6868	broad.mit.edu	37	chr2	9642395	9642395	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtttttacagcaaggacTgttcctgtcactggagaaga	12	11	10	8	0	1	2	1	0	0	2	2	4	2	3	1	2	2	3	1	2	3	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:9642395T>A	uc002qzu.2	-	13	1738	c.1555A>T	c.(1555-1557)AGT>TGT	p.S519C	ADAM17_uc010ewy.2_Missense_Mutation_p.S519C|ADAM17_uc010ewz.2_Intron	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	519	Disintegrin.|Extracellular (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		CAGCAAGGACTGTTCCTGTCA	0.468													43	40					0	0	0	0	A	9642395	A	A	9642395	3	1	103	1	0	0	0	0	1	0	0	0	238	1580	55	5	947	5	ADAM17	2	9642395	Missense_Mutation	SNP	T	TCGA-CQ-6221-01A-11D-2078-08		9642395	233556978	17	19511											
YWHAQ	10971	broad.mit.edu	37	chr2	9728378	9728378	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttaagagcaagccccaggcgGattgggtgtgtgggttgcat	8	10	16	7	1	0	1	0	0	0	1	0	2	0	2	2	4	3	3	2	4	2	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:9728378G>C	uc002qzw.2	-	3	662	c.498C>G	c.(496-498)ATC>ATG	p.I166M	YWHAQ_uc002qzx.2_Missense_Mutation_p.I166M	NM_006826	NP_006817	P27348	1433T_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	166					negative regulation of transcription, DNA-dependent	centrosome|nucleus	protein N-terminus binding			breast(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.241)		GCCCCAGGCGGATTGGGTGTG	0.428													26	21					0	0	0	0	C	9728378	C	C	9728378	3	2	103	1	0	0	0	0	1	0	0	0	17573	1164	41	2	251	2	YWHAQ	2	9728378	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	85983	9728378	233470995	18	19512											
C2orf16	84226	broad.mit.edu	37	chr2	27803934	27803934	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaaatgaaacctccagccagGagtctaagaacttgtccaca	15	7	8	11	0	1	2	0	1	1	1	3	4	3	3	4	1	3	0	4	1	4	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:27803934G>C	uc002rkz.3	+	1	4546	c.4495G>C	c.(4495-4497)GAG>CAG	p.E1499Q	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1499										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CTCCAGCCAGGAGTCTAAGAA	0.478													34	71					0	0	0	0	C	27803934	C	C	27803934	3	2	103	1	0	0	0	0	1	0	0	0	2167	1175	41	2	4497	2	C2orf16	2	27803934	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	18075556	27803934	215395439	19	19513											
ALK	238	broad.mit.edu	37	chr2	30143411	30143411	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgagtggctcccggggctGcagcggcggccccgcagctg	3	5	18	15	4	0	1	0	1	0	0	1	1	1	1	3	5	3	6	3	5	0	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:30143411G>A	uc002rmy.2	-	1	1022	c.115C>T	c.(115-117)CAG>TAG	p.Q39*		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	39	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TCCCGGGGCTGCAGCGGCGGC	0.706			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				4	12					0	0	0	0	A	30143411	A	A	30143411	4	1	103	1	0	0	0	0	0	1	0	0	525	1328	46	4	4863	4	ALK	2	30143411	Nonsense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	2339477	30143411	213055962	20	19514											
HEATR5B	54497	broad.mit.edu	37	chr2	37310507	37310507	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actggtctttttgcttcggtGatttgagccaaagcttcttc	6	17	9	9	1	2	2	0	2	2	0	4	2	2	2	1	2	3	2	1	2	1	6			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:37310507G>A	uc002rpp.1	-	2	147	c.51C>T	c.(49-51)ATC>ATT	p.I17I	CCDC75_uc010ezz.2_5'Flank|CCDC75_uc002rpr.3_5'Flank	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	17							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				TTGCTTCGGTGATTTGAGCCA	0.363													14	38					0	0	0	0	A	37310507	A	A	37310507	2	1	103	1	0	0	0	0	0	0	0	1	7071	1280	45	2		2	HEATR5B	2	37310507	Silent	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	7167096	37310507	205888866	21	19515											
GPR39	2863	broad.mit.edu	37	chr2	133402786	133402786	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctacttccgggcgtacatGatcctcctccccttctcgga	5	12	7	17	3	1	1	0	1	1	0	7	2	6	2	6	2	2	1	6	2	2	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:133402786G>T	uc002ttl.2	+	2	1438	c.969G>T	c.(967-969)ATG>ATT	p.M323I	LYPD1_uc002ttm.3_3'UTR|LYPD1_uc002ttn.2_3'UTR|LYPD1_uc002tto.2_3'UTR	NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	323	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						GGGCGTACATGATCCTCCTCC	0.587													21	45					1.9806e-07	2.2211e-07	1	0	T	133402786	T	T	133402786	3	4	103	1	0	0	0	0	1	0	0	0	6731	1290	45	2	975	2	GPR39	2	133402786	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	96092279	133402786	109796587	22	19516											
SCRN3	79634	broad.mit.edu	37	chr2	175263019	175263019	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagttaaaaaaaatggaacCtttttcctgtgacactttcg	13	15	6	7	1	0	1	0	1	0	0	2	2	1	2	2	1	1	1	2	1	6	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:175263019C>A	uc002uiq.2	+	2	96	c.8C>A	c.(7-9)CCT>CAT	p.P3H	CIR1_uc002uim.2_5'Flank|CIR1_uc002uin.2_5'Flank|CIR1_uc002uio.2_5'Flank|CIR1_uc002uip.2_5'Flank|SCRN3_uc010zen.1_Intron|SCRN3_uc010zeo.1_5'UTR|SCRN3_uc002uir.1_RNA	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	3					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			AAAATGGAACCTTTTTCCTGT	0.289													6	55					0.00116845	0.00121487	1	0	A	175263019	A	A	175263019	3	1	103	1	0	0	0	0	1	0	0	0	14005	681	24	4	10	4	SCRN3	2	175263019	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	41860233	175263019	67936354	23	19517											
GPR155	151556	broad.mit.edu	37	chr2	175330545	175330545	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggtgctatagagggagctgTacaatagaacaaacaccaaa	18	6	10	7	0	0	2	0	0	0	2	0	3	0	3	1	2	5	3	1	2	8	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:175330545T>C	uc002uit.2	-	8	1743	c.1352A>G	c.(1351-1353)TAC>TGC	p.Y451C	GPR155_uc002uiu.2_Missense_Mutation_p.Y451C|GPR155_uc002uiv.2_Missense_Mutation_p.Y451C|GPR155_uc010fqs.2_Missense_Mutation_p.Y423C	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	451	Helical; (Potential).				intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						GAGGGAGCTGTACAATAGAAC	0.388													5	15					0	0	0	0	C	175330545	C	C	175330545	3	2	103	1	0	0	0	0	1	0	0	0	6698	1638	57	5	1300	5	GPR155	2	175330545	Missense_Mutation	SNP	T	TCGA-CQ-6221-01A-11D-2078-08	67526	175330545	67868828	24	19518											
MSTN	2660	broad.mit.edu	37	chr2	190927237	190927237	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttttccacattttcttttTgctcactgttctcatttaga	6	22	3	10	0	3	1	2	0	2	1	5	1	4	1	1	0	1	2	1	0	1	9			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:190927237T>C	uc002urp.2	-	1	219	c.86A>G	c.(85-87)CAA>CGA	p.Q29R		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	29					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			ATTTTCTTTTTGCTCACTGTT	0.348													35	74					0	0	0	0	C	190927237	C	C	190927237	3	2	103	1	0	0	0	0	1	0	0	0	9946	1812	63	5	1053	5	MSTN	2	190927237	Missense_Mutation	SNP	T	TCGA-CQ-6221-01A-11D-2078-08	15596692	190927237	52272136	25	19519											
CLK1	1195	broad.mit.edu	37	chr2	201726085	201726085	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctttcatggtctctttggCgatgtccaggttcacatcct	5	15	10	11	1	3	0	2	0	1	0	6	1	5	0	2	4	0	2	2	4	0	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:201726085C>G	uc002uwe.2	-	3	447	c.266G>C	c.(265-267)CGC>CCC	p.R89P	CLK1_uc010zhi.1_Missense_Mutation_p.R131P|CLK1_uc002uwf.2_5'UTR|CLK1_uc002uwg.2_5'UTR|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	89					cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						GTCTCTTTGGCGATGTCCAGG	0.403													50	101					0	0	0	0	G	201726085	G	G	201726085	3	3	103	1	0	0	0	0	1	0	0	0	3551	768	27	3	1232	3	CLK1	2	201726085	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	10798848	201726085	41473288	26	19520											
USP37	57695	broad.mit.edu	37	chr2	219362475	219362475	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acattctgcatataaccagaGaatctctctgctgtagctga	12	12	7	10	0	3	2	0	1	3	1	4	3	3	2	1	0	4	4	1	0	4	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:219362475G>C	uc002vie.2	-	13	1716	c.1263C>G	c.(1261-1263)TTC>TTG	p.F421L	USP37_uc010fvs.1_Missense_Mutation_p.F421L|USP37_uc010zkf.1_Missense_Mutation_p.F421L|USP37_uc002vif.2_Missense_Mutation_p.F421L|USP37_uc002vig.2_Missense_Mutation_p.F349L	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	421					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TATAACCAGAGAATCTCTCTG	0.244													21	38					0	0	0	0	C	219362475	C	C	219362475	3	2	103	1	0	0	0	0	1	0	0	0	17136	933	33	2	1732	2	USP37	2	219362475	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	17636390	219362475	23836898	27	19521											
C2orf83	56918	broad.mit.edu	37	chr2	228476316	228476316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtcagcccgcatgtctgtaCggtaagtttcctcatccctg	6	12	10	13	2	3	0	2	0	1	0	5	0	5	0	3	2	2	4	3	2	2	3	rs111332429	byFrequency	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:228476316C>T	uc002vph.2	-	3	482	c.247G>A	c.(247-249)GTA>ATA	p.V83I	C2orf83_uc010zlu.1_3'UTR	NM_020161	NP_064546	Q53S99	CB083_HUMAN	hypothetical protein LOC56918 isoform 1	83						membrane	folic acid binding|reduced folate carrier activity				0						CATGTCTGTACGGTAAGTTTC	0.468													22	38					0	0	0	0	T	228476316	T	T	228476316	3	4	103	1	0	0	0	0	1	0	0	0	2208	536	19	1	209	1	C2orf83	2	228476316	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	9113841	228476316	14723057	28	19522											
DNER	92737	broad.mit.edu	37	chr2	230272008	230272008	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgctgtcacaggtggctcCgttcagacagctgacgttag	7	10	13	11	3	2	2	2	1	0	1	4	2	3	2	1	2	1	5	1	2	1	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:230272008C>G	uc002vpv.2	-	10	1810	c.1663G>C	c.(1663-1665)GGA>CGA	p.G555R		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	555	Extracellular (Potential).|Follistatin-like.|EGF-like 9.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		CAGGTGGCTCCGTTCAGACAG	0.512													18	79					0	0	0	0	G	230272008	G	G	230272008	3	3	103	1	0	0	0	0	1	0	0	0	4689	661	23	3	566	3	DNER	2	230272008	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	1795692	230272008	12927365	29	19523											
STK25	10494	broad.mit.edu	37	chr2	242441064	242441064	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccttgtagacctccccaaaCgagcccttgccaatgcggtc	8	8	8	17	2	0	1	0	0	0	1	2	2	1	1	6	1	4	1	6	1	3	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:242441064C>T	uc002wbm.2	-	2	361	c.90G>A	c.(88-90)TCG>TCA	p.S30S	STK25_uc002wbk.2_5'Flank|STK25_uc002wbl.2_5'Flank|STK25_uc002wbn.2_Silent_p.S30S|STK25_uc002wbo.2_Intron|STK25_uc010zos.1_5'UTR|STK25_uc010zot.1_5'UTR|STK25_uc002wbp.2_Silent_p.S30S|STK25_uc010fzo.2_Intron|STK25_uc010zou.1_5'UTR|STK25_uc010zov.1_5'UTR|STK25_uc010zow.1_Silent_p.S30S	NM_006374	NP_006365	O00506	STK25_HUMAN	serine/threonine kinase 25	30	ATP (By similarity).|Protein kinase.				response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		CCTCCCCAAACGAGCCCTTGC	0.612													5	73					0	0	0	0	T	242441064	T	T	242441064	2	4	103	1	0	0	0	0	0	0	0	1	15360	523	19	1		1	STK25	2	242441064	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	12169056	242441064	758309	30	19524											
TTC14	151613	broad.mit.edu	37	chr3	180328289	180328289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaatatatttaatcagataGctgaatttgaaaaagaaaaa	21	12	6	2	0	1	5	1	3	0	2	1	5	1	5	0	0	1	1	0	0	10	6			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:180328289G>A	uc003fkk.2	+	12	2404	c.2272G>A	c.(2272-2274)GCT>ACT	p.A758T	TTC14_uc003fkl.2_3'UTR|TTC14_uc003fkm.2_Intron	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	758							RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TAATCAGATAGCTGAATTTGA	0.313													8	86					0	0	0	0	A	180328289	A	A	180328289	3	1	103	1	0	0	0	0	1	0	0	0	16749	971	34	4	2348	4	TTC14	3	180328289	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08		180328289	17694141	31	19525											
MCF2L2	23101	broad.mit.edu	37	chr3	183006931	183006931	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttcaaatttagtctcatCatcttcctttccccgggagt	8	15	6	12	1	4	0	3	0	2	0	7	2	6	1	3	1	0	0	3	1	2	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:183006931C>T	uc003fli.1	-	14	1843	c.1753G>A	c.(1753-1755)GAT>AAT	p.D585N	MCF2L2_uc003flj.1_Missense_Mutation_p.D585N|MCF2L2_uc011bqr.1_RNA|uc003fln.1_Intron	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	585					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TTAGTCTCATCATCTTCCTTT	0.403													21	33					0	0	0	0	T	183006931	T	T	183006931	3	4	103	1	0	0	0	0	1	0	0	0	9433	826	29	2	1659	2	MCF2L2	3	183006931	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	2678642	183006931	15015499	32	19526											
HTR3D	200909	broad.mit.edu	37	chr3	183756319	183756329	+	Frame_Shift_Del	DEL	CTGCTGCTGCA	-	-																															tgcctcggtggctccactccCtgctgctgcactgcaccggc																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:183756319_183756329delCTGCTGCTGCA	uc011bqv.1	+	7	1042_1052	c.1042_1052delCTGCTGCTGCA	c.(1042-1053)CTGCTGCTGCACfs	p.L348fs	HTR3D_uc003fmj.2_Frame_Shift_Del_p.L173fs|HTR3D_uc011bqu.1_Frame_Shift_Del_p.L298fs|HTR3D_uc010hxp.2_Frame_Shift_Del_p.L127fs	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	348_351	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCTCCACTCCCTGCTGCTGCACTGCACCGGC	0.649													---	---	---								-	183756329	-	-	183756319	7	5	103	1	0	1	0	1	0	0	0	0	7486	680	24	0	1238	0	HTR3D	3	183756319	Frame_Shift_Del	DEL	CTGCTGCTGCA	TCGA-CQ-6221-01A-11D-2078-08	749388	183756319	14266111	33	19527											
EHHADH	1962	broad.mit.edu	37	chr3	184910480	184910493	+	Frame_Shift_Del	DEL	CCTAATTCACAGAG	-	-																															ctgtcttctggccaaatcgtCctaattcacagagcacatca																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:184910480_184910493delCCTAATTCACAGAG	uc003fpf.2	-	7	1720_1733	c.1693_1706delCTCTGTGAATTAGG	c.(1693-1707)CTCTGTGAATTAGGAfs	p.L565fs	EHHADH_uc011brs.1_Frame_Shift_Del_p.L469fs	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	565_569	3-hydroxyacyl-CoA dehydrogenase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	GCCAAATCGTCCTAATTCACAGAGCACATCAGGA	0.472													---	---	---								-	184910493	-	-	184910480	7	5	103	1	0	1	0	1	0	0	0	0	5004	855	30	0	469	0	EHHADH	3	184910480	Frame_Shift_Del	DEL	CCTAATTCACAGAG	TCGA-CQ-6221-01A-11D-2078-08	1154161	184910480	13111950	34	19528											
MUC4	4585	broad.mit.edu	37	chr3	195516484	195516484	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcttggtgtcagtcatggggGagacggacctcgtggtttgt	5	13	16	7	2	3	1	2	0	1	1	4	3	3	2	1	5	0	1	1	5	0	2	rs3749330	by1000genomes	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:195516484G>C	uc011bto.1	-	2	2427	c.1967C>G	c.(1966-1968)TCC>TGC	p.S656C	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.S538C	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	661					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGTCATGGGGGAGACGGACCT	0.562													12	172					0	0	0	0	C	195516484	C	C	195516484	3	2	103	1	0	0	0	0	1	0	0	0	10031	1174	41	2		2	MUC4	3	195516484	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	10606004	195516484	2505946	35	19529											
FAM193A	8603	broad.mit.edu	37	chr4	2717749	2717749	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttctcttttgttttacaGatgatgtctttctacctaaa	8	20	5	8	0	3	2	0	1	3	1	4	2	3	2	1	0	3	2	1	0	4	8			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:2717749G>C	uc010icl.2	+	19	3974	c.3623_splice	c.e19-1	p.D1208_splice	FAM193A_uc010ick.2_Splice_Site_p.D1367_splice|FAM193A_uc003gfd.2_Splice_Site_p.D1167_splice|FAM193A_uc011bvm.1_Splice_Site_p.D1189_splice|FAM193A_uc011bvn.1_Splice_Site_p.D1167_splice|FAM193A_uc011bvo.1_Splice_Site|FAM193A_uc010icm.2_Splice_Site	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603											ovary(3)	3						TTGTTTTACAGATGATGTCTT	0.378													28	52					0	0	0	0	C	2717749	C	C	2717749	5	2	103	1	0	0	0	0	0	0	1	0	5552	956	33	2	3561	2	FAM193A	4	2717749	Splice_Site	SNP	G	TCGA-CQ-6221-01A-11D-2078-08		2717749	188436527	36	19530											
RBPJ	3516	broad.mit.edu	37	chr4	26432465	26432465	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacctttacctacacaccaGaaccagggccgcggccacat	11	7	7	16	2	0	1	0	0	0	1	0	1	0	1	6	2	4	0	6	2	4	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:26432465G>C	uc003grx.1	+	12	1575	c.1339G>C	c.(1339-1341)GAA>CAA	p.E447Q	RBPJ_uc003gry.1_Missense_Mutation_p.E432Q|RBPJ_uc003grz.1_Missense_Mutation_p.E447Q|RBPJ_uc003gsa.1_Missense_Mutation_p.E433Q|RBPJ_uc003gsb.1_Missense_Mutation_p.E434Q|RBPJ_uc003gsc.1_3'UTR|uc003gsd.2_5'Flank	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	447					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				CTACACACCAGAACCAGGGCC	0.527													17	41					0	0	0	0	C	26432465	C	C	26432465	3	2	103	1	0	0	0	0	1	0	0	0	13226	943	33	2	1444	2	RBPJ	4	26432465	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	23714716	26432465	164721811	37	19531											
LPHN3	23284	broad.mit.edu	37	chr4	62849282	62849282	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcactcattgtggctgtgtCagctgcagtagactacagga	9	11	12	9	0	2	1	2	0	0	1	2	2	2	2	0	2	4	5	0	2	2	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:62849282C>T	uc010ihh.2	+	16	3166	c.2993C>T	c.(2992-2994)TCA>TTA	p.S998L	LPHN3_uc003hcq.3_Missense_Mutation_p.S998L|LPHN3_uc003hct.2_Missense_Mutation_p.S391L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	985	Helical; Name=4; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GTGGCTGTGTCAGCTGCAGTA	0.383													36	90					0	0	0	0	T	62849282	T	T	62849282	3	4	103	1	0	0	0	0	1	0	0	0	8967	838	29	2	3055	2	LPHN3	4	62849282	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	36416817	62849282	128304994	38	19532											
UGT2B4	7363	broad.mit.edu	37	chr4	70360953	70360953	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagatcatattttttaccctCtctatgaaagtcatttggtc	10	18	5	8	0	3	2	2	1	1	1	5	2	3	2	1	1	1	0	1	1	5	7			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:70360953C>T	uc003hek.3	-	1	674	c.627G>A	c.(625-627)GAG>GAA	p.E209E	UGT2B4_uc011cap.1_Silent_p.E73E|UGT2B4_uc003hel.3_Silent_p.E209E	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	209					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TTTTTACCCTCTCTATGAAAG	0.378													11	29					0	0	0	0	T	70360953	T	T	70360953	2	4	103	1	0	0	0	0	0	0	0	1	17029	912	32	2		2	UGT2B4	4	70360953	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	7511671	70360953	120793323	39	19533											
ENAM	10117	broad.mit.edu	37	chr4	71509483	71509483	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggcagagagaaagaaggccGtattttaacagaaatatctg	16	8	12	5	1	1	4	0	0	1	4	1	5	1	4	1	2	1	2	1	2	6	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:71509483G>A	uc011caw.1	+	9	2621	c.2340G>A	c.(2338-2340)CCG>CCA	p.P780P		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	780					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AAAGAAGGCCGTATTTTAACA	0.473													20	35					0	0	0	0	A	71509483	A	A	71509483	2	1	103	1	0	0	0	0	0	0	0	1	5136	1132	40	1		1	ENAM	4	71509483	Silent	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	1148530	71509483	119644793	40	19534											
FBXW7	55294	broad.mit.edu	37	chr4	153247255	153247255	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccataaaatcatatgctccaCtaacaaccctcctgccatca	14	9	2	16	0	2	0	2	0	0	0	4	0	4	0	5	0	4	1	5	0	5	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:153247255C>T	uc003ims.2	-	10	1696	c.1547G>A	c.(1546-1548)AGT>AAT	p.S516N	FBXW7_uc011cii.1_Missense_Mutation_p.S516N|FBXW7_uc003imt.2_Missense_Mutation_p.S516N|FBXW7_uc011cih.1_Missense_Mutation_p.S340N|FBXW7_uc003imq.2_Missense_Mutation_p.S436N|FBXW7_uc003imr.2_Missense_Mutation_p.S398N	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	516	WD 4.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ATATGCTCCACTAACAACCCT	0.443			Mis|N|D|F		colorectal|endometrial|T-ALL								22	122					0	0	0	0	T	153247255	T	T	153247255	3	4	103	1	0	0	0	0	1	0	0	0	5801	565	20	4	588	4	FBXW7	4	153247255	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	81737772	153247255	37907021	41	19535											
FBXL7	23194	broad.mit.edu	37	chr5	15937151	15937151	+	Frame_Shift_Del	DEL	G	-	-																															tgcgagagcatcaccggccaGggcttgcagatcgtggccgc																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr5:15937151delG	uc003jfn.1	+	4	1813	c.1332delG	c.(1330-1332)CAGfs	p.Q444fs		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	444	LRR 11.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						TCACCGGCCAGGGCTTGCAGA	0.612													---	---	---								-	15937151	-	-	15937151	7	5	103	1	0	1	0	1	0	0	0	0	5756	991	35	0	1346	0	FBXL7	5	15937151	Frame_Shift_Del	DEL	G	TCGA-CQ-6221-01A-11D-2078-08		15937151	164978109	42	19536											
HSPA4	3308	broad.mit.edu	37	chr5	132427046	132427046	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagccaatggaaacagatCagaatgcaaaggaggaagag	19	3	14	5	0	1	3	1	0	0	3	1	7	1	7	1	4	3	1	1	4	5	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr5:132427046C>T	uc003kyj.2	+	12	1821	c.1540C>T	c.(1540-1542)CAG>TAG	p.Q514*		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	514					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGAAACAGATCAGAATGCAAA	0.438													11	13					0	0	0	0	T	132427046	T	T	132427046	4	4	103	1	0	0	0	0	0	1	0	0	7451	827	29	2	1586	2	HSPA4	5	132427046	Nonsense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	116489895	132427046	48488214	43	19537											
HIST1H1D	3007	broad.mit.edu	37	chr6	26234945	26234945	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgttgtttttttctacatCgtagccagcagccgcaagcg	7	13	10	11	3	1	0	0	0	1	0	2	0	1	0	2	0	5	6	2	0	3	6			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:26234945C>T	uc003nhd.2	-	1	272	c.217G>A	c.(217-219)GAT>AAT	p.D73N		NM_005320	NP_005311	P16402	H13_HUMAN	histone cluster 1, H1d	73	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TTTTCTACATCGTAGCCAGCA	0.542													34	80					0	0	0	0	T	26234945	T	T	26234945	3	4	103	1	0	0	0	0	1	0	0	0	7164	884	31	1	452	1	HIST1H1D	6	26234945	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08		26234945	144880122	44	19538											
SH3BGRL2	83699	broad.mit.edu	37	chr6	80383466	80383466	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccggaaaagaaacccactCagggcaaccccctgccacct	12	3	7	19	1	1	1	1	0	0	1	1	2	1	2	7	2	3	1	7	2	4	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:80383466C>G	uc003piz.1	+	2	360	c.181C>G	c.(181-183)CAG>GAG	p.Q61E		NM_031469	NP_113657	Q9UJC5	SH3L2_HUMAN	SH3 domain binding glutamic acid-rich protein	61	SH3-binding (Potential).					nucleus	SH3 domain binding				0		all_cancers(76;0.00188)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.174)		BRCA - Breast invasive adenocarcinoma(397;0.0278)		GAAACCCACTCAGGGCAACCC	0.458													27	60					0	0	0	0	G	80383466	G	G	80383466	3	3	103	1	0	0	0	0	1	0	0	0	14307	827	29	2	187	2	SH3BGRL2	6	80383466	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	54148521	80383466	90731601	45	19539											
MAP3K7	6885	broad.mit.edu	37	chr6	91246083	91246083	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttctgttccagttacagtCaagtcttggatggatctacg	8	14	11	8	1	4	0	1	0	3	0	5	2	5	2	1	3	2	3	1	3	3	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:91246083C>G	uc003pnz.1	-	13	1491	c.1329G>C	c.(1327-1329)TTG>TTC	p.L443F	MAP3K7_uc003pny.1_5'UTR|MAP3K7_uc003poa.1_Missense_Mutation_p.L443F|MAP3K7_uc003pob.1_Missense_Mutation_p.L416F|MAP3K7_uc003poc.1_Missense_Mutation_p.L416F	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	443					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CAGTTACAGTCAAGTCTTGGA	0.343													13	28					0	0	0	0	G	91246083	G	G	91246083	3	3	103	1	0	0	0	0	1	0	0	0	9308	825	29	2	511	2	MAP3K7	6	91246083	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	10862617	91246083	79868984	46	19540											
REV3L	5980	broad.mit.edu	37	chr6	111680071	111680071	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaatcactattacacctgtGagttctgttttttctgtatc	8	19	5	9	0	4	1	2	1	2	0	5	1	4	1	1	0	1	3	1	0	4	7			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:111680071G>A	uc003puy.3	-	17	7349	c.7026C>T	c.(7024-7026)CTC>CTT	p.L2342L	REV3L_uc003pux.3_Silent_p.L2264L|REV3L_uc003puz.3_Silent_p.L2264L|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2342					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TTACACCTGTGAGTTCTGTTT	0.398								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					26	58					0	0	0	0	A	111680071	A	A	111680071	2	1	103	1	0	0	0	0	0	0	0	1	13305	1277	45	2		2	REV3L	6	111680071	Silent	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	20433988	111680071	59434996	47	19541											
ROS1	6098	broad.mit.edu	37	chr6	117708099	117708099	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaactctcctgggccaaagCtatttaatggtttactccaa	12	12	7	10	0	1	1	0	0	1	1	3	1	2	1	3	2	3	2	3	2	6	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:117708099C>T	uc003pxp.1	-	14	2277	c.2078G>A	c.(2077-2079)AGC>AAC	p.S693N	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	693	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGGGCCAAAGCTATTTAATGG	0.383			T	GOPC|ROS1	glioblastoma|NSCLC								29	50					0	0	0	0	T	117708099	T	T	117708099	3	4	103	1	0	0	0	0	1	0	0	0	13596	797	28	4	5085	4	ROS1	6	117708099	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	6028028	117708099	53406968	48	19542											
RAB32	10981	broad.mit.edu	37	chr6	146865145	146865145	+	Frame_Shift_Del	DEL	C	-	-																															agcatcatcaagcgctacgtCcaccagctcttctcccagca																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:146865145delC	uc003qln.1	+	1	318	c.138delC	c.(136-138)GTCfs	p.V46fs		NM_006834	NP_006825	Q13637	RAB32_HUMAN	RAB32, member RAS oncogene family	46					protein transport|small GTPase mediated signal transduction	mitochondrion	GTP binding				0		Ovarian(120;0.142)		OV - Ovarian serous cystadenocarcinoma(155;2.68e-09)|GBM - Glioblastoma multiforme(68;0.00608)		AGCGCTACGTCCACCAGCTCT	0.562													---	---	---								-	146865145	-	-	146865145	7	5	103	1	0	1	0	1	0	0	0	0	12986	842	30	0	140	0	RAB32	6	146865145	Frame_Shift_Del	DEL	C	TCGA-CQ-6221-01A-11D-2078-08	29157046	146865145	24249922	49	19543											
SNX9	51429	broad.mit.edu	37	chr6	158330947	158330947	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccttattttgtagaacactaAtcgatctgtaaaccacaggt	13	13	6	9	1	1	1	0	0	1	1	2	2	1	1	2	1	2	2	2	1	6	6			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:158330947A>G	uc003qqv.1	+	9	1012	c.839A>G	c.(838-840)AAT>AGT	p.N280S		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	280	PX.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		TAGAACACTAATCGATCTGTA	0.393													32	56					0	0	0	0	G	158330947	G	G	158330947	3	3	103	1	0	0	0	0	1	0	0	0	14973	101	4	5	873	5	SNX9	6	158330947	Missense_Mutation	SNP	A	TCGA-CQ-6221-01A-11D-2078-08	11465802	158330947	12784120	50	19544											
WTAP	9589	broad.mit.edu	37	chr6	160176488	160176488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagactctcccacgggcagtGaaaactctctcacacaccaa	13	7	6	15	1	3	2	1	1	2	1	5	2	3	2	2	1	1	1	2	1	4	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:160176488G>A	uc003qsl.2	+	8	1258	c.1036G>A	c.(1036-1038)GAA>AAA	p.E346K	WTAP_uc003qso.2_Missense_Mutation_p.E227K	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	346					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		CACGGGCAGTGAAAACTCTCT	0.507													24	41					0	0	0	0	A	160176488	A	A	160176488	3	1	103	1	0	0	0	0	1	0	0	0	17477	1291	45	2	1066	2	WTAP	6	160176488	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	1845541	160176488	10938579	51	19545											
ZNF735	730291	broad.mit.edu	37	chr7	63667602	63667603	+	Frame_Shift_Ins	INS	-	T	T																															ggctaaaagaccgggaccccINSctggaagccgagaaatggtg																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr7:63667602_63667603insT	uc011kdn.1	+	1	22_23	c.22_23insT	c.(22-24)CCTfs	p.P8fs		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACCGGGACCCCCTGGAAGCCGA	0.564													---	---	---								T	63667603	T	T	63667602	7	5	103	1	0	1	1	0	0	0	0	0	18191	623	22	0	24	0	ZNF735	7	63667602	Frame_Shift_Ins	INS	-	TCGA-CQ-6221-01A-11D-2078-08		63667602	95471061	52	19546											
MSRA	4482	broad.mit.edu	37	chr8	10285683	10285683	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcagagcacggcttcggccCcatcactaccgacatccggg	8	7	10	16	4	2	1	2	0	0	1	4	2	3	1	4	3	2	2	4	3	1	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:10285683C>T	uc003wsx.2	+	6	766	c.569C>T	c.(568-570)CCC>CTC	p.P190L	MSRA_uc011kwx.1_Missense_Mutation_p.P150L|MSRA_uc003wsz.2_Missense_Mutation_p.P147L|MSRA_uc003wsy.2_Missense_Mutation_p.P124L	NM_012331	NP_036463	Q9UJ68	MSRA_HUMAN	methionine sulfoxide reductase A isoform a	190					methionine metabolic process|protein modification process|response to oxidative stress	mitochondrion|nucleus	peptide-methionine-(S)-S-oxide reductase activity				0		Myeloproliferative disorder(644;0.178)			L-Methionine(DB00134)	GGCTTCGGCCCCATCACTACC	0.597													14	26					0	0	0	0	T	10285683	T	T	10285683	3	4	103	1	0	0	0	0	1	0	0	0	9940	623	22	4	608	4	MSRA	8	10285683	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08		10285683	136078339	53	19547											
FAM160B2	64760	broad.mit.edu	37	chr8	21958395	21958395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acttcaccgacagcttcctgGattccggctttcaaactccc	8	11	6	16	2	2	0	2	0	0	0	5	2	5	1	4	2	2	2	4	2	1	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:21958395G>A	uc011kyx.1	+	12	1579	c.1528G>A	c.(1528-1530)GAT>AAT	p.D510N	FAM160B2_uc011kyy.1_RNA	NM_022749	NP_073586	Q86V87	F16B2_HUMAN	retinoic acid induced 16	510											0						CAGCTTCCTGGATTCCGGCTT	0.572													34	78					0	0	0	0	A	21958395	A	A	21958395	3	1	103	1	0	0	0	0	1	0	0	0	5499	1174	41	2	1373	2	FAM160B2	8	21958395	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	11672712	21958395	124405627	54	19548											
ADAM7	8756	broad.mit.edu	37	chr8	24326281	24326281	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	attttccctaactttacaggGcatccatgatgaaaagtatg	13	13	7	8	0	0	2	0	2	0	0	2	2	2	2	2	1	2	2	2	1	5	6			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:24326281G>A	uc003xeb.2	+	7	694	c.581G>A	c.(580-582)GGC>GAC	p.G194D		NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	194	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		ACTTTACAGGGCATCCATGAT	0.308													3	41					0	0	0	0	A	24326281	A	A	24326281	3	1	103	1	0	0	0	0	1	0	0	0	251	1217	42	4	607	4	ADAM7	8	24326281	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	2367886	24326281	122037741	55	19549											
IKBKB	3551	broad.mit.edu	37	chr8	42176820	42176820	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccgaaacaacagctgcctctCcaaaatgaagaattccatgg	15	7	7	12	1	1	2	0	1	1	1	3	3	2	2	4	1	4	1	4	1	6	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:42176820C>G	uc003xow.1	+	14	1574	c.1397C>G	c.(1396-1398)TCC>TGC	p.S466C	IKBKB_uc010lxh.1_Missense_Mutation_p.S361C|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.S243C|IKBKB_uc003xox.1_Missense_Mutation_p.S187C|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.S464C|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.S407C	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	466	Leucine-zipper.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	AGCTGCCTCTCCAAAATGAAG	0.473											OREG0018747	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	93					0	0	0	0	G	42176820	G	G	42176820	3	3	103	1	0	0	0	0	1	0	0	0	7650	855	30	2	1447	2	IKBKB	8	42176820	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	17850539	42176820	104187202	56	19550											
PAG1	55824	broad.mit.edu	37	chr8	81897257	81897257	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tggggccctgggagctctttCgaggcagaagtagattttgc	7	11	15	8	1	1	2	0	0	1	2	2	4	1	3	1	4	2	3	1	4	2	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:81897257C>G	uc003ybz.2	-	7	1341	c.630G>C	c.(628-630)TCG>TCC	p.S210S		NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid	210	Cytoplasmic (Potential).				epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			GGAGCTCTTTCGAGGCAGAAG	0.488													23	49					0	0	0	0	G	81897257	G	G	81897257	2	3	103	1	0	0	0	0	0	0	0	1	11442	871	31	3		3	PAG1	8	81897257	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	39720437	81897257	64466765	57	19551											
UBR5	51366	broad.mit.edu	37	chr8	103301699	103301699	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acctcttccacatctgctgaAacaatatcatcctgttcttc	10	14	3	14	0	4	1	1	1	3	0	7	1	6	1	3	0	2	2	3	0	3	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:103301699A>T	uc003ykr.1	-	35	4728	c.4695T>A	c.(4693-4695)GTT>GTA	p.V1565V	UBR5_uc003yks.1_Silent_p.V1565V	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1565					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CATCTGCTGAAACAATATCAT	0.403													16	61					0	0	0	0	T	103301699	T	T	103301699	2	4	103	1	0	0	0	0	0	0	0	1	16973	1	1	5		5	UBR5	8	103301699	Silent	SNP	A	TCGA-CQ-6221-01A-11D-2078-08	21404442	103301699	43062323	58	19552											
EIF3E	3646	broad.mit.edu	37	chr8	109254111	109254111	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatcactaagaaggtccaatTtaccttgtaataattccttt	13	16	4	8	0	1	1	1	0	0	1	3	1	3	1	3	1	1	1	3	1	7	9			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:109254111T>G	uc003ymu.2	-	2	150	c.122A>C	c.(121-123)AAA>ACA	p.K41T	EIF3E_uc003ymt.2_5'UTR|EIF3E_uc003ymv.2_Intron|EIF3E_uc010mci.1_Missense_Mutation_p.K41T|EIF3E_uc010mcj.1_Missense_Mutation_p.K41T	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	41	Sufficient for interaction with TRIM27.|Sufficient for interaction with EPAS1.				negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			AAGGTCCAATTTACCTTGTAA	0.284													10	41					0	0	0	0	G	109254111	G	G	109254111	3	3	103	1	0	0	0	0	1	0	0	0	5039	1841	64	5	1263	5	EIF3E	8	109254111	Missense_Mutation	SNP	T	TCGA-CQ-6221-01A-11D-2078-08	5952412	109254111	37109911	59	19553											
OPLAH	26873	broad.mit.edu	37	chr8	145107094	145107094	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctccaggatctcagggtCggtgatgcgtgtgttggtca	5	12	15	9	2	3	1	2	1	2	0	6	2	3	2	1	4	1	2	1	4	0	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:145107094C>A	uc003zar.3	-	24	3521	c.3439G>T	c.(3439-3441)GAC>TAC	p.D1147Y		NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1147							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	ATCTCAGGGTCGGTGATGCGT	0.622													6	6					3.59834e-05	3.86944e-05	1	0	A	145107094	A	A	145107094	3	1	103	1	0	0	0	0	1	0	0	0	10930	884	31	3	445	3	OPLAH	8	145107094	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	35852983	145107094	1256928	60	19554											
ABCA2	20	broad.mit.edu	37	chr9	139907546	139907546	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atggggcgggcgagggtgggGgtggcacgaaattggacagt	8	6	22	5	3	0	0	0	0	0	0	0	3	0	1	0	8	0	1	0	8	1	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr9:139907546G>C	uc011mem.1	-	29	4920	c.4772C>G	c.(4771-4773)CCC>CGC	p.P1591R	ABCA2_uc011mel.1_Missense_Mutation_p.P1592R|ABCA2_uc004ckl.1_Missense_Mutation_p.P1522R|ABCA2_uc004ckm.1_Missense_Mutation_p.P1622R|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1591					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGAGGGTGGGGGTGGCACGAA	0.677													13	1					0	0	0	0	C	139907546	C	C	139907546	3	2	103	1	0	0	0	0	1	0	0	0	32	1232	43	4	2615	4	ABCA2	9	139907546	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08		139907546	1305885	61	19555											
CUBN	8029	broad.mit.edu	37	chr10	16873286	16873286	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagatgatttcatatccaCgatcagaagttacactatca	14	12	5	10	1	3	3	3	1	0	2	5	4	5	3	2	0	1	1	2	0	4	4	rs143300012	byFrequency	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr10:16873286C>T	uc001ioo.2	-	65	10545	c.10493G>A	c.(10492-10494)CGT>CAT	p.R3498H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3498	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTCATATCCACGATCAGAAGT	0.393													20	24					0	0	0	0	T	16873286	T	T	16873286	3	4	103	1	0	0	0	0	1	0	0	0	4068	536	19	1	390	1	CUBN	10	16873286	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08		16873286	118661461	62	19556											
ARMC4	55130	broad.mit.edu	37	chr10	28272787	28272787	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacaccatttaaaaatacTcctcctgcactgcaagtaat	14	12	3	12	0	0	0	0	0	0	0	2	0	2	0	3	0	4	3	3	0	7	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr10:28272787T>A	uc009xky.2	-	6	902	c.804A>T	c.(802-804)GGA>GGT	p.G268G	ARMC4_uc010qds.1_5'Flank|ARMC4_uc010qdt.1_5'Flank|ARMC4_uc001itz.2_Silent_p.G268G|ARMC4_uc010qdu.1_5'Flank	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	268							binding			ovary(4)|skin(2)	6						TTAAAAATACTCCTCCTGCAC	0.433													12	26					0	0	0	0	A	28272787	A	A	28272787	2	1	103	1	0	0	0	0	0	0	0	1	955	1538	54	5		5	ARMC4	10	28272787	Silent	SNP	T	TCGA-CQ-6221-01A-11D-2078-08	11399501	28272787	107261960	63	19557											
OR13A1	79290	broad.mit.edu	37	chr10	45799323	45799323	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggggccacagaaatccaagCgcagcatcagccccgtgtgg	10	5	13	13	2	1	1	1	0	0	1	2	1	2	1	4	3	3	2	4	3	2	0	rs116633831	byFrequency	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr10:45799323C>G	uc001jcc.1	-	4	857	c.548G>C	c.(547-549)CGC>CCC	p.R183P	OR13A1_uc001jcd.1_Missense_Mutation_p.R179P	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GAAATCCAAGCGCAGCATCAG	0.592													20	48					0	0	0	0	G	45799323	G	G	45799323	3	3	103	1	0	0	0	0	1	0	0	0	10987	768	27	3	442	3	OR13A1	10	45799323	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	17526536	45799323	89735424	64	19558											
MYPN	84665	broad.mit.edu	37	chr10	69881386	69881386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatgaccttccagatctttCagcctttctgagccaagaag	11	11	8	11	0	3	5	1	2	2	3	4	5	4	5	4	0	2	0	4	0	2	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr10:69881386C>T	uc001jnm.3	+	3	376	c.191C>T	c.(190-192)TCA>TTA	p.S64L	MYPN_uc001jnl.1_Missense_Mutation_p.S64L|MYPN_uc001jnn.3_Intron|MYPN_uc001jno.3_Missense_Mutation_p.S64L|MYPN_uc001jnp.1_Missense_Mutation_p.S64L|MYPN_uc009xps.2_Missense_Mutation_p.S64L|MYPN_uc009xpt.2_Missense_Mutation_p.S64L|MYPN_uc010qit.1_5'UTR|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	64	Interaction with CARP.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CCAGATCTTTCAGCCTTTCTG	0.527													19	53					0	0	0	0	T	69881386	T	T	69881386	3	4	103	1	0	0	0	0	1	0	0	0	10151	838	29	2	193	2	MYPN	10	69881386	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	24082063	69881386	65653361	65	19559											
CALHM2	51063	broad.mit.edu	37	chr10	105207026	105207026	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccctggttctcacggtacaaGtagacgccggtgatggcatt	8	10	12	11	3	1	2	1	1	1	1	2	2	1	2	2	4	1	4	2	4	3	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr10:105207026G>C	uc001kwz.2	-	3	1241	c.855C>G	c.(853-855)TAC>TAG	p.Y285*	CALHM2_uc001kxa.2_Nonsense_Mutation_p.Y285*|CALHM2_uc001kxc.2_3'UTR|CALHM2_uc001kxb.2_Nonsense_Mutation_p.Y285*	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	285						integral to membrane				skin(1)	1						CACGGTACAAGTAGACGCCGG	0.617													19	43					0	0	0	0	C	105207026	C	C	105207026	4	2	103	1	0	0	0	0	0	1	0	0	2595	1024	36	4	120	4	CALHM2	10	105207026	Nonsense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	35325640	105207026	30327721	66	19560											
FXC1	26515	broad.mit.edu	37	chr11	6503307	6503307	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagctgtgctgggaagctGatccattccaaccaccgcct	9	8	9	15	1	0	1	0	1	0	0	2	2	2	2	5	1	4	3	5	1	2	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:6503307G>C	uc001mdn.3	+	3	238	c.168G>C	c.(166-168)CTG>CTC	p.L56L	ARFIP2_uc001mdk.2_5'Flank|ARFIP2_uc001mdl.2_5'Flank|ARFIP2_uc010ral.1_5'Flank|ARFIP2_uc010ram.1_5'Flank|ARFIP2_uc010ran.1_5'Flank|ARFIP2_uc001mdm.2_5'Flank|ARFIP2_uc009yfe.1_5'Flank|FXC1_uc001mdo.3_RNA	NM_012192	NP_036324	Q9Y5J6	TIM9B_HUMAN	mitochondrial import inner membrane translocase	56					cell-matrix adhesion|protein import into mitochondrial inner membrane|transmembrane transport	mitochondrial inner membrane|mitochondrial intermembrane space protein transporter complex	metal ion binding				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;3.26e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTGGGAAGCTGATCCATTCCA	0.602													21	58					0	0	0	0	C	6503307	C	C	6503307	2	2	103	1	0	0	0	0	0	0	0	1	6147	1277	45	2		2	FXC1	11	6503307	Silent	SNP	G	TCGA-CQ-6221-01A-11D-2078-08		6503307	128503209	67	19561											
FIBIN	387758	broad.mit.edu	37	chr11	27016191	27016191	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgcaccactacttcgtgcccGatggggactatgaggagaac	10	8	12	11	2	0	2	0	1	0	1	1	5	0	3	2	3	4	1	2	3	3	3	rs144159497		TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:27016191G>C	uc001mrd.2	+	1	564	c.118G>C	c.(118-120)GAT>CAT	p.D40H		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	40						extracellular region|Golgi apparatus					0						CTTCGTGCCCGATGGGGACTA	0.592													18	17					0	0	0	0	C	27016191	C	C	27016191	3	2	103	1	0	0	0	0	1	0	0	0	5917	1058	37	3	120	3	FIBIN	11	27016191	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	20512884	27016191	107990325	68	19562											
PDHX	8050	broad.mit.edu	37	chr11	34978997	34978997	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatagtagaagaaggagaaGattggaaacatgttgaaatt	18	10	12	1	0	0	6	0	2	0	4	0	8	0	7	0	2	1	2	0	2	7	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:34978997G>C	uc001mvt.2	+	4	935	c.409G>C	c.(409-411)GAT>CAT	p.D137H	PDHX_uc010rep.1_Missense_Mutation_p.D122H|PDHX_uc010req.1_Intron	NM_003477	NP_003468	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	137					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			kidney(1)	1	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			AGAAGGAGAAGATTGGAAACA	0.403													20	55					0	0	0	0	C	34978997	C	C	34978997	3	2	103	1	0	0	0	0	1	0	0	0	11721	942	33	2	542	2	PDHX	11	34978997	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	7962806	34978997	100027519	69	19563											
RAG1	5896	broad.mit.edu	37	chr11	36595094	36595094	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagtcccaactcagccattGttaaaagcccaccctaagtt	12	9	5	15	0	1	0	1	0	0	0	2	0	2	0	5	0	3	2	5	0	4	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:36595094G>C	uc001mwu.3	+	2	364	c.240G>C	c.(238-240)TTG>TTC	p.L80F	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	80	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				CTCAGCCATTGTTAAAAGCCC	0.488									Familial_Hemophagocytic_Lymphohistiocytosis				17	108					0	0	0	0	C	36595094	C	C	36595094	3	2	103	1	0	0	0	0	1	0	0	0	13068	1368	48	4	242	4	RAG1	11	36595094	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	1616097	36595094	98411422	70	19564											
AHNAK	79026	broad.mit.edu	37	chr11	62291028	62291028	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggagggtaacatcgacttCagggccttctcctttgaagc	9	10	12	10	1	2	1	1	1	1	0	4	3	2	2	2	3	2	1	2	3	2	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62291028C>T	uc001ntl.2	-	5	11161	c.10861G>A	c.(10861-10863)GAA>AAA	p.E3621K	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3621					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACATCGACTTCAGGGCCTTCT	0.483													78	81					0	0	0	0	T	62291028	T	T	62291028	3	4	103	1	0	0	0	0	1	0	0	0	414	835	29	2	6931	2	AHNAK	11	62291028	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	25695934	62291028	72715488	71	19565			1	23		8	8	8804	N	C	2.475996e-14
AHNAK	79026	broad.mit.edu	37	chr11	62291184	62291184	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggccctttcagatccccttCaagtttgggaagagaaatat	11	12	9	9	0	2	2	2	0	0	2	3	4	3	3	3	2	0	1	3	2	4	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62291184C>T	uc001ntl.2	-	5	11005	c.10705G>A	c.(10705-10707)GAA>AAA	p.E3569K	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3569					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGATCCCCTTCAAGTTTGGGA	0.458													83	55					0	0	0	0	T	62291184	T	T	62291184	3	4	103	1	0	0	0	0	1	0	0	0	414	835	29	2	7087	2	AHNAK	11	62291184	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	156	62291184	72715332	72	19566			1	23		8	8	8804	N	C	2.475996e-14
AHNAK	79026	broad.mit.edu	37	chr11	62292529	62292529	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatccacgtcaggaactttCatgtcaccttccacttttgg	9	14	6	12	1	3	0	3	0	0	0	5	1	5	1	3	2	1	0	3	2	2	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62292529C>T	uc001ntl.2	-	5	9660	c.9360G>A	c.(9358-9360)ATG>ATA	p.M3120I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3120					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CAGGAACTTTCATGTCACCTT	0.468													92	99					0	0	0	0	T	62292529	T	T	62292529	3	4	103	1	0	0	0	0	1	0	0	0	414	826	29	2	8432	2	AHNAK	11	62292529	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	1345	62292529	72713987	73	19567			1	23		8	8	8804	N	C	2.475996e-14
AHNAK	79026	broad.mit.edu	37	chr11	62292958	62292958	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaatatccacatcgcccttCaccttgggacctttcagatg	10	11	7	13	1	2	1	2	0	0	1	4	3	3	2	4	1	0	0	4	1	2	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62292958C>T	uc001ntl.2	-	5	9231	c.8931G>A	c.(8929-8931)GTG>GTA	p.V2977V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2977					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CATCGCCCTTCACCTTGGGAC	0.507													66	67					0	0	0	0	T	62292958	T	T	62292958	2	4	103	1	0	0	0	0	0	0	0	1	414	813	29	2		2	AHNAK	11	62292958	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	429	62292958	72713558	74	19568			1	23		8	8	8804	N	C	2.475996e-14
AHNAK	79026	broad.mit.edu	37	chr11	62294979	62294979	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggggtcttgaagtgcatctCaggcatcttaaacttggggc	8	11	14	8	0	3	1	1	1	3	0	4	1	3	1	0	5	2	2	0	5	3	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62294979C>G	uc001ntl.2	-	5	7210	c.6910G>C	c.(6910-6912)GAG>CAG	p.E2304Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2304					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AAGTGCATCTCAGGCATCTTA	0.478													80	87					0	0	0	0	G	62294979	G	G	62294979	3	3	103	1	0	0	0	0	1	0	0	0	414	835	29	2	10882	2	AHNAK	11	62294979	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	2021	62294979	72711537	75	19569			1	23		8	8	8804	N	C	2.475996e-14
AHNAK	79026	broad.mit.edu	37	chr11	62295736	62295736	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctgaacttgggcattttCatcttgggcatcttcaggtg	7	15	11	8	0	4	1	2	1	2	0	4	1	4	1	0	3	2	3	0	3	1	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62295736C>A	uc001ntl.2	-	5	6453	c.6153G>T	c.(6151-6153)ATG>ATT	p.M2051I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2051					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGCATTTTCATCTTGGGCA	0.512													137	127					7.45053e-56	8.66469e-56	1	0	A	62295736	A	A	62295736	3	1	103	1	0	0	0	0	1	0	0	0	414	826	29	2	11639	2	AHNAK	11	62295736	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	757	62295736	72710780	76	19570			1	23		8	8	8804	N	C	2.475996e-14
AHNAK	79026	broad.mit.edu	37	chr11	62296638	62296638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatatccaaatcaggagcatCagtgtccacactgggtccag	13	8	9	11	0	2	0	2	0	0	0	5	1	5	1	3	2	1	1	3	2	3	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62296638C>T	uc001ntl.2	-	5	5551	c.5251G>A	c.(5251-5253)GAT>AAT	p.D1751N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1751					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCAGGAGCATCAGTGTCCACA	0.483													76	62					0	0	0	0	T	62296638	T	T	62296638	3	4	103	1	0	0	0	0	1	0	0	0	414	826	29	2	12541	2	AHNAK	11	62296638	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	902	62296638	72709878	77	19571			1	23		8	8	8804	N	C	2.475996e-14
AHNAK	79026	broad.mit.edu	37	chr11	62299831	62299831	+	Frame_Shift_Del	DEL	C	-	-																															ttgacactcatatcaggcagCttaacatcggggcctttaag																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62299831delC	uc001ntl.2	-	5	2358	c.2058delG	c.(2056-2058)AAGfs	p.K686fs	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	686					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TATCAGGCAGCTTAACATCGG	0.473													---	---	---								-	62299831	-	-	62299831	7	5	103	1	0	1	0	1	0	0	0	0	414	796	28	0	15734	0	AHNAK	11	62299831	Frame_Shift_Del	DEL	C	TCGA-CQ-6221-01A-11D-2078-08	3193	62299831	72706685	78	19572			1	23		8	8	8804	N	C	2.475996e-14
FAT3	120114	broad.mit.edu	37	chr11	92523229	92523229	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctgcagattgaagccacaGatagagatgagaagcacaag	16	6	11	8	0	0	5	0	2	0	4	1	7	1	5	2	0	3	2	2	0	4	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:92523229G>C	uc001pdj.3	+	7	4473	c.4456G>C	c.(4456-4458)GAT>CAT	p.D1486H		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1486	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAAGCCACAGATAGAGATGA	0.468										TCGA Ovarian(4;0.039)			41	44					0	0	0	0	C	92523229	C	C	92523229	3	2	103	1	0	0	0	0	1	0	0	0	5723	942	33	2	4482	2	FAT3	11	92523229	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	30223398	92523229	42483287	79	19573											
SLC6A13	6540	broad.mit.edu	37	chr12	332337	332337	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggactcgaagatggccaCgaacaggaggcacatgccac	13	3	14	11	2	0	1	0	0	0	1	1	6	0	3	2	4	2	1	2	4	2	0	rs145396701	by1000genomes	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:332337C>A	uc001qic.1	-	12	1428	c.1375G>T	c.(1375-1377)GTG>TTG	p.V459L	SLC6A13_uc009zdj.1_Missense_Mutation_p.V449L|SLC6A13_uc010sdl.1_Missense_Mutation_p.V367L	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	459	Helical; Name=10; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			AAGATGGCCACGAACAGGAGG	0.522													7	22					7.48243e-07	8.27283e-07	1	0	A	332337	A	A	332337	3	1	103	1	0	0	0	0	1	0	0	0	14740	536	19	3	449	3	SLC6A13	12	332337	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08		332337	133519558	80	19574											
NINJ2	4815	broad.mit.edu	37	chr12	675268	675268	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacagggccacgtccagcAtgctctccgccacgctcttc	7	8	9	17	3	2	1	0	1	2	0	5	1	3	1	4	1	3	3	4	1	1	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:675268A>G	uc001qil.2	-	2	339	c.248T>C	c.(247-249)ATG>ACG	p.M83T	NINJ2_uc010sdr.1_Missense_Mutation_p.M1T|NINJ2_uc010sds.1_Missense_Mutation_p.M83T	NM_016533	NP_057617	Q9NZG7	NINJ2_HUMAN	ninjurin 2	37	Extracellular (Potential).				nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				ovary(2)	2	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			CACGTCCAGCATGCTCTCCGC	0.602													11	34					0	0	0	0	G	675268	G	G	675268	3	3	103	1	0	0	0	0	1	0	0	0	10473	217	8	5	326	5	NINJ2	12	675268	Missense_Mutation	SNP	A	TCGA-CQ-6221-01A-11D-2078-08	342931	675268	133176627	81	19575											
LALBA	3906	broad.mit.edu	37	chr12	48962875	48962875	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctactcactgtcacaggaGatgtcacagatgttccttga	10	11	10	10	0	3	3	3	1	0	2	4	4	4	3	1	2	1	2	1	2	1	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:48962875G>C	uc001rrt.2	-	2	308	c.282C>G	c.(280-282)ATC>ATG	p.I94M		NM_002289	NP_002280	P00709	LALBA_HUMAN	lactalbumin, alpha- precursor	94					cell-cell signaling|defense response to bacterium|induction of apoptosis|lactose biosynthetic process|signal transduction	extracellular space	calcium ion binding|lactose synthase activity				0						TGTCACAGGAGATGTCACAGA	0.468													19	76					0	0	0	0	C	48962875	C	C	48962875	3	2	103	1	0	0	0	0	1	0	0	0	8644	932	33	2	158	2	LALBA	12	48962875	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	48287607	48962875	84889020	82	19576											
MLL2	8085	broad.mit.edu	37	chr12	49443703	49443703	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagagcccaggaggggctctGagccaggaaaactggcactg	11	4	16	10	0	1	2	0	1	1	1	1	5	1	4	2	5	3	2	2	5	2	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:49443703G>C	uc001rta.3	-	11	3668	c.3668C>G	c.(3667-3669)TCA>TGA	p.S1223*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1223					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GAGGGGCTCTGAGCCAGGAAA	0.612			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			29	42					0	0	0	0	C	49443703	C	C	49443703	4	2	103	1	0	0	0	0	0	1	0	0	9674	1294	45	2	13121	2	MLL2	12	49443703	Nonsense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	480828	49443703	84408192	83	19577											
METTL1	4234	broad.mit.edu	37	chr12	58162860	58162879	+	Frame_Shift_Del	DEL	CTTCCCTCCATTACGTAGAA	-	-																															cggaagatggctgggaaattCttccctccattacgtagaac																								rs140194153	byFrequency	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:58162860_58162879delCTTCCCTCCATTACGTAGAA	uc010ssd.1	-	6	779_798	c.731_750delTTCTACGTAATGGAGGGAAG	c.(730-750)GTTCTACGTAATGGAGGGAAGfs	p.V244fs	CYP27B1_uc001spz.1_5'Flank|CYP27B1_uc001sqa.1_5'Flank|METTL1_uc009zqc.2_3'UTR	NM_005371	NP_005362	Q9UBP6	TRMB_HUMAN	methyltransferase-like protein 1 isoform a	244_250						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding				0	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			CTGGGAAATTCTTCCCTCCATTACGTAGAACTTTCTTCCC	0.527													---	---	---								-	58162879	-	-	58162860	7	5	103	1	0	1	0	1	0	0	0	0	9546	912	32	0	84	0	METTL1	12	58162860	Frame_Shift_Del	DEL	CTTCCCTCCATTACGTAGAA	TCGA-CQ-6221-01A-11D-2078-08	8719157	58162860	75689035	84	19578											
OAS2	4939	broad.mit.edu	37	chr12	113442855	113442855	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgagcggcacaaaatcgtCaaggaaatccatgaacagct	17	5	9	10	3	1	1	1	1	0	0	3	3	2	2	1	2	4	2	1	2	6	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:113442855C>A	uc001tuj.2	+	7	1436	c.1296C>A	c.(1294-1296)GTC>GTA	p.V432V	OAS2_uc001tui.1_Silent_p.V432V	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	432	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						ACAAAATCGTCAAGGAAATCC	0.507													4	27					0.00024832	0.000261653	1	0	A	113442855	A	A	113442855	2	1	103	1	0	0	0	0	0	0	0	1	10854	813	29	2		2	OAS2	12	113442855	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	55279995	113442855	20409040	85	19579											
NOS1	4842	broad.mit.edu	37	chr12	117703229	117703230	+	Frame_Shift_Ins	INS	-	C	C																															acacccagtcggcagggcagINScccccccggcagcggtactc																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:117703229_117703230insC	uc001twm.1	-	12	2713_2714	c.2027_2028insG	c.(2026-2028)GGCfs	p.G676fs		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	676					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CGGCAGGGCAGCCCCCCCGGCA	0.604													---	---	---								C	117703230	C	C	117703229	7	5	103	1	0	1	1	0	0	0	0	0	10595	958	34	0	2348	0	NOS1	12	117703229	Frame_Shift_Ins	INS	-	TCGA-CQ-6221-01A-11D-2078-08	4260374	117703229	16148666	86	19580											
BRCA2	675	broad.mit.edu	37	chr13	32903578	32903578	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacataaatttttatcttacAgtcagaaatgaagaagcatc	17	12	5	7	0	2	3	1	1	1	2	3	3	2	3	0	0	2	1	0	0	7	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr13:32903578A>C	uc001uub.1	+	8	859	c.632_splice	c.e8-2	p.V211_splice	BRCA2_uc001uua.1_Splice_Site_p.V88_splice	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset						cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding	p.?(1)		ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TTTATCTTACAGTCAGAAATG	0.284			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			5	2					0	0	0	0	C	32903578	C	C	32903578	5	2	103	1	0	0	0	0	0	0	1	0	1504	202	7	5	656	5	BRCA2	13	32903578	Splice_Site	SNP	A	TCGA-CQ-6221-01A-11D-2078-08		32903578	82266300	87	19581											
C13orf23	80209	broad.mit.edu	37	chr13	39587551	39587551	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaggccgagggagtaggaCttgtgggctcagttttgatc	8	11	16	6	1	1	2	1	2	0	0	2	5	1	4	1	4	0	3	1	4	2	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr13:39587551C>A	uc001uwy.2	-	11	2711	c.1838G>T	c.(1837-1839)AGT>ATT	p.S613I	C13orf23_uc001uwz.2_Missense_Mutation_p.S591I	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	613	Ser-rich.									ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		GGGAGTAGGACTTGTGGGCTC	0.502													37	50					1.30998e-17	1.51226e-17	1	0	A	39587551	A	A	39587551	3	1	103	1	0	0	0	0	1	0	0	0	1727	565	20	4	1008	4	C13orf23	13	39587551	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	6683973	39587551	75582327	88	19582											
UTP14C	9724	broad.mit.edu	37	chr13	52603224	52603229	+	In_Frame_Del	DEL	CTTCAT	-	-																															tctgcttgagcccgttaaaaCttcatcttctttggccactg																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr13:52603224_52603229delCTTCAT	uc001vgb.2	+	2	819_824	c.284_289delCTTCAT	c.(283-291)ACTTCATCT>ACT	p.SS96del	UTP14C_uc001vga.2_3'UTR|UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	96_97					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		CCCGTTAAAACTTCATCTTCTTTGGC	0.427													---	---	---								-	52603229	-	-	52603224	7	5	103	1	0	1	0	1	0	0	0	0	17164	565	20	0	286	0	UTP14C	13	52603224	In_Frame_Del	DEL	CTTCAT	TCGA-CQ-6221-01A-11D-2078-08	13015673	52603224	62566654	89	19583											
PCDH8	5100	broad.mit.edu	37	chr13	53419750	53419750	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccggctcctttccaaaaccCggggaggcaccgtagggctg	7	6	14	14	3	0	0	0	0	0	0	2	1	2	1	5	5	1	4	5	5	3	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr13:53419750C>T	uc001vhi.2	-	2	2852	c.2649G>A	c.(2647-2649)CCG>CCA	p.P883P	PCDH8_uc001vhj.2_Silent_p.P786P	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	883	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TTCCAAAACCCGGGGAGGCAC	0.557													4	32					0	0	0	0	T	53419750	T	T	53419750	2	4	103	1	0	0	0	0	0	0	0	1	11571	639	23	1		1	PCDH8	13	53419750	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	816526	53419750	61750128	90	19584											
GPC5	2262	broad.mit.edu	37	chr13	92051386	92051386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgcagcgagggcgtgcagaCctgcgaagaagttcggaaac	11	4	15	11	5	0	2	0	0	0	2	1	5	0	3	2	2	4	3	2	2	3	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr13:92051386C>T	uc010tif.1	+	1	452	c.86C>T	c.(85-87)ACC>ATC	p.T29I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	29						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GGCGTGCAGACCTGCGAAGAA	0.672													14	5					0	0	0	0	T	92051386	T	T	92051386	3	4	103	1	0	0	0	0	1	0	0	0	6639	507	18	4	88	4	GPC5	13	92051386	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	38631636	92051386	23118492	91	19585											
SLC22A17	51310	broad.mit.edu	37	chr14	23821365	23821365	+	Frame_Shift_Del	DEL	A	-	-																															agccagaggcattaggggggAaggccccgtagtggcaatgc																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr14:23821365delA	uc001wjl.2	-	1	115	c.59delT	c.(58-60)TTCfs	p.F20fs	SLC22A17_uc010akk.2_5'UTR|SLC22A17_uc001wjn.2_RNA|SLC22A17_uc001wjm.2_Frame_Shift_Del_p.F20fs|SLC22A17_uc010akl.1_Frame_Shift_Del_p.F20fs	NM_020372	NP_065105	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17 isoform a	20					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity				0	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		ATTAGGGGGGAAGGCCCCGTA	0.711													---	---	---								-	23821365	-	-	23821365	7	5	103	1	0	1	0	1	0	0	0	0	14513	246	9	0	1593	0	SLC22A17	14	23821365	Frame_Shift_Del	DEL	A	TCGA-CQ-6221-01A-11D-2078-08		23821365	83528175	92	19586											
SPG11	80208	broad.mit.edu	37	chr15	44862786	44862786	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcatgtgggcggcctgtagGactcggatgatgccctccat	7	9	14	11	2	0	1	0	1	0	0	2	3	1	3	3	4	2	2	3	4	1	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:44862786G>A	uc001ztx.2	-	34	6445	c.6414C>T	c.(6412-6414)GTC>GTT	p.V2138V	SPG11_uc010bdw.2_Silent_p.V268V|SPG11_uc010ueh.1_Silent_p.V2025V|SPG11_uc010uei.1_Silent_p.V2138V	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	2138	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CGGCCTGTAGGACTCGGATGA	0.592													4	20					0	0	0	0	A	44862786	A	A	44862786	2	1	103	1	0	0	0	0	0	0	0	1	15107	1161	41	2		2	SPG11	15	44862786	Silent	SNP	G	TCGA-CQ-6221-01A-11D-2078-08		44862786	57668606	93	19587											
SEMA6D	80031	broad.mit.edu	37	chr15	48060877	48060877	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctaaactgacaagctctcGgaaatttgtagttcaagatg	14	11	8	8	1	2	2	1	1	1	1	3	3	2	3	1	1	2	3	1	1	6	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:48060877G>A	uc010bek.2	+	18	2225	c.1865G>A	c.(1864-1866)CGG>CAG	p.R622Q	SEMA6D_uc001zvw.2_Intron|SEMA6D_uc001zvy.2_Missense_Mutation_p.R622Q|SEMA6D_uc001zvz.2_Intron|SEMA6D_uc001zwa.2_Intron|SEMA6D_uc001zwb.2_Intron|SEMA6D_uc001zwc.2_Intron	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	622	Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		ACAAGCTCTCGGAAATTTGTA	0.428													13	60					0	0	0	0	A	48060877	A	A	48060877	3	1	103	1	0	0	0	0	1	0	0	0	14107	1116	39	1	1974	1	SEMA6D	15	48060877	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	3198091	48060877	54470515	94	19588											
TEX9	374618	broad.mit.edu	37	chr15	56719843	56719843	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaaaaaattgaagtgttaaAatcagaaaacaagaagctag	23	7	7	4	0	1	3	1	1	0	2	1	3	1	3	0	0	2	2	0	0	11	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:56719843A>T	uc002adp.2	+	11	1009	c.1004A>T	c.(1003-1005)AAA>ATA	p.K335I	TEX9_uc010ugl.1_Missense_Mutation_p.K260I	NM_198524	NP_940926	Q8N6V9	TEX9_HUMAN	testis expressed 9	335	Potential.										0				all cancers(107;0.0394)|GBM - Glioblastoma multiforme(80;0.056)		GAAGTGTTAAAATCAGAAAAC	0.279													10	42					0	0	0	0	T	56719843	T	T	56719843	3	4	103	1	0	0	0	0	1	0	0	0	15850	14	1	5	1046	5	TEX9	15	56719843	Missense_Mutation	SNP	A	TCGA-CQ-6221-01A-11D-2078-08	8658966	56719843	45811549	95	19589											
ALDH1A2	8854	broad.mit.edu	37	chr15	58306120	58306120	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaacagacgtcccctttctGaagcatccatccttctccac	9	10	4	18	1	2	2	0	1	2	1	6	2	5	2	6	0	2	1	6	0	2	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:58306120G>C	uc002aex.2	-	3	357	c.299C>G	c.(298-300)TCA>TGA	p.S100*	ALDH1A2_uc002aey.2_Nonsense_Mutation_p.S100*|ALDH1A2_uc010ugv.1_Nonsense_Mutation_p.S79*|ALDH1A2_uc010ugw.1_Nonsense_Mutation_p.S71*|ALDH1A2_uc002aew.2_Nonsense_Mutation_p.S4*	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	100					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TCCCCTTTCTGAAGCATCCAT	0.488													47	149					0	0	0	0	C	58306120	C	C	58306120	4	2	103	1	0	0	0	0	0	1	0	0	491	1294	45	2	1301	2	ALDH1A2	15	58306120	Nonsense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	1586277	58306120	44225272	96	19590											
CSNK1G1	53944	broad.mit.edu	37	chr15	64495283	64495283	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaggatcaacacatacctGatttcgaagaggctgctgtt	11	11	11	8	1	1	2	1	1	0	1	2	5	1	4	1	3	3	3	1	3	3	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:64495283G>C	uc002anf.2	-	10	1585	c.1105C>G	c.(1105-1107)CAG>GAG	p.Q369E	CSNK1G1_uc002ane.2_RNA|CSNK1G1_uc002ang.1_Missense_Mutation_p.Q369E|CSNK1G1_uc002anh.1_Missense_Mutation_p.Q369E|CSNK1G1_uc002anj.2_Missense_Mutation_p.Q351E	NM_022048	NP_071331	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	369					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0						ACACATACCTGATTTCGAAGA	0.443													6	10					0	0	0	0	C	64495283	C	C	64495283	3	2	103	1	0	0	0	0	1	0	0	0	3971	1299	45	2	175	2	CSNK1G1	15	64495283	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	6189163	64495283	38036109	97	19591											
AEN	64782	broad.mit.edu	37	chr15	89169569	89169569	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caccagcggttcatggcccgGaaggccttgctgcaggagca	8	6	14	13	2	1	0	1	0	0	0	1	2	1	2	3	5	4	4	3	5	1	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:89169569G>A	uc002bmt.2	+	2	280	c.129G>A	c.(127-129)CGG>CGA	p.R43R	AEN_uc010bnl.2_Silent_p.R43R|AEN_uc010bnm.1_Silent_p.R43R	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	43					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						TCATGGCCCGGAAGGCCTTGC	0.627													22	5					0	0	0	0	A	89169569	A	A	89169569	2	1	103	1	0	0	0	0	0	0	0	1	351	1161	41	2		2	AEN	15	89169569	Silent	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	24674286	89169569	13361823	98	19592											
SEMA4B	10509	broad.mit.edu	37	chr15	90771754	90771754	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agacagccccccggggtcccGagtcttcactgagtcagaga	9	6	12	14	2	3	3	2	1	1	2	4	5	4	3	4	2	1	0	4	2	0	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:90771754G>C	uc002boy.2	+	15	2676	c.2393G>C	c.(2392-2394)CGA>CCA	p.R798P	SEMA4B_uc002boz.2_Missense_Mutation_p.R798P|SEMA4B_uc010uqd.1_Missense_Mutation_p.R636P|SEMA4B_uc002bpa.2_Missense_Mutation_p.R636P|SEMA4B_uc010bnv.1_Intron	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			CCGGGGTCCCGAGTCTTCACT	0.677													10	12					0	0	0	0	C	90771754	C	C	90771754	3	2	103	1	0	0	0	0	1	0	0	0	14097	1058	37	3	2447	3	SEMA4B	15	90771754	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	1602185	90771754	11759638	99	19593											
ABCA3	21	broad.mit.edu	37	chr16	2333284	2333284	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatgaggtaggcgcaccctGaggcggccatggaggccaca	9	4	17	11	2	0	2	0	2	0	0	0	4	0	4	3	7	0	2	3	7	1	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:2333284G>C	uc002cpy.1	-	26	4650	c.3938C>G	c.(3937-3939)TCA>TGA	p.S1313*	ABCA3_uc010bsk.1_Nonsense_Mutation_p.S1255*	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1313	Helical; (Potential).				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				GGCGCACCCTGAGGCGGCCAT	0.647													12	27					0	0	0	0	C	2333284	C	C	2333284	4	2	103	1	0	0	0	0	0	1	0	0	33	1294	45	2	1208	2	ABCA3	16	2333284	Nonsense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08		2333284	88021469	100	19594											
ACSM1	116285	broad.mit.edu	37	chr16	20673130	20673130	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccatacctggtgaaatcctgCtgcagaatcattcgatatat	12	12	7	10	1	1	2	1	1	0	1	3	3	2	2	3	1	3	2	3	1	5	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:20673130C>T	uc002dhm.1	-	6	1046	c.978G>A	c.(976-978)CAG>CAA	p.Q326Q	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Silent_p.Q326Q	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	326					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						TGAAATCCTGCTGCAGAATCA	0.368													18	26					0	0	0	0	T	20673130	T	T	20673130	2	4	103	1	0	0	0	0	0	0	0	1	182	796	28	4		4	ACSM1	16	20673130	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	18339846	20673130	69681623	101	19595											
DNAH3	55567	broad.mit.edu	37	chr16	21086866	21086878	+	Frame_Shift_Del	DEL	CACCAATGGGCTC	-	-																															gtattccttgctggcagctgCaccaatgggctccaatctaa																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:21086866_21086878delCACCAATGGGCTC	uc010vbe.1	-	21	2974_2986	c.2974_2986delGAGCCCATTGGTG	c.(2974-2988)GAGCCCATTGGTGCAfs	p.E992fs		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	992_996	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTGGCAGCTGCACCAATGGGCTCCAATCTAAAG	0.399													---	---	---								-	21086878	-	-	21086866	7	5	103	1	0	1	0	1	0	0	0	0	4625	710	25	0	9531	0	DNAH3	16	21086866	Frame_Shift_Del	DEL	CACCAATGGGCTC	TCGA-CQ-6221-01A-11D-2078-08	413736	21086866	69267887	102	19596											
ITGAX	3687	broad.mit.edu	37	chr16	31374532	31374532	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctacggggagcagggccAcccctggggtcgctttgggg	4	8	17	12	2	1	0	0	0	1	0	3	1	1	1	3	7	2	2	3	7	1	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:31374532A>T	uc002ebu.1	+	14	1614	c.1547A>T	c.(1546-1548)CAC>CTC	p.H516L	ITGAX_uc002ebt.2_Missense_Mutation_p.H516L|ITGAX_uc010vfk.1_Missense_Mutation_p.H166L	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	516	Extracellular (Potential).|FG-GAP 6.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GAGCAGGGCCACCCCTGGGGT	0.632													19	80					0	0	0	0	T	31374532	T	T	31374532	3	4	103	1	0	0	0	0	1	0	0	0	7928	159	6	5	1601	5	ITGAX	16	31374532	Missense_Mutation	SNP	A	TCGA-CQ-6221-01A-11D-2078-08	10287666	31374532	58980221	103	19597											
ZNF319	57567	broad.mit.edu	37	chr16	58031375	58031375	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagagcggtgcttgaaggtCttctcgcagactgcgcactt	7	11	13	10	3	2	3	0	2	2	2	3	4	2	3	0	2	3	3	0	2	1	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:58031375C>A	uc002emx.1	-	2	1418	c.795G>T	c.(793-795)AAG>AAT	p.K265N		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	265	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCTTGAAGGTCTTCTCGCAGA	0.612													9	37					3.09899e-07	3.45064e-07	1	0	A	58031375	A	A	58031375	3	1	103	1	0	0	0	0	1	0	0	0	17904	912	32	2	957	2	ZNF319	16	58031375	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	26656843	58031375	32323378	104	19598											
TERF2	7014	broad.mit.edu	37	chr16	69400835	69400843	+	In_Frame_Del	DEL	GACCAATCT	-	-																															ctctggctgtcctcctccaaGaccaatctgcttattgtcat																										TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:69400835_69400843delGACCAATCT	uc002exd.2	-	7	1206_1214	c.1081_1089delAGATTGGTC	c.(1081-1089)AGATTGGTCdel	p.RLV361del		NM_005652	NP_005643	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	361_363					age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			lung(1)	1		Ovarian(137;0.101)				CCTCCTCCAAGACCAATCTGCTTATTGTC	0.569													---	---	---								-	69400843	-	-	69400835	7	5	103	1	0	1	0	1	0	0	0	0	15828	929	33	0	429	0	TERF2	16	69400835	In_Frame_Del	DEL	GACCAATCT	TCGA-CQ-6221-01A-11D-2078-08	11369460	69400835	20953918	105	19599											
HYDIN	54768	broad.mit.edu	37	chr16	70843707	70843707	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcagtagtattctgtcctCtgccgtgtgtaattgatgaa	8	15	10	8	1	2	2	0	2	2	0	3	2	3	2	2	0	2	4	2	0	4	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:70843707C>G	uc002ezr.2	-	85	14987	c.14859G>C	c.(14857-14859)CAG>CAC	p.Q4953H	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4954										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ATTCTGTCCTCTGCCGTGTGT	0.517													58	94					0	0	0	0	G	70843707	G	G	70843707	3	3	103	1	0	0	0	0	1	0	0	0	7506	912	32	2	511	2	HYDIN	16	70843707	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	1442872	70843707	19511046	106	19600											
TP53	7157	broad.mit.edu	37	chr17	7577124	7577124	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggacaggcacaaacacgcaCctcaaagctgttccgtccca	13	5	8	15	2	1	0	1	0	0	0	3	1	3	1	3	2	2	4	3	2	2	1	rs121912657		TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:7577124C>T	uc002gim.2	-	8	1008	c.814G>A	c.(814-816)GTG>ATG	p.V272M	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.V272M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V140M|TP53_uc010cng.1_Missense_Mutation_p.V140M|TP53_uc002gii.1_Missense_Mutation_p.V140M|TP53_uc010cnh.1_Missense_Mutation_p.V272M|TP53_uc010cni.1_Missense_Mutation_p.V272M|TP53_uc002gij.2_Missense_Mutation_p.V272M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	272	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in sporadic cancers; somatic mutation).|V -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> A (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V272M(67)|p.V272L(24)|p.V272E(8)|p.0?(7)|p.V272A(7)|p.V272G(4)|p.V272fs*73(4)|p.V272V(3)|p.?(2)|p.F270fs*72(1)|p.E271fs*73(1)|p.V272fs*34(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.G266_E271delGRNSFE(1)|p.V272fs*74(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAACACGCACCTCAAAGCTG	0.527		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	8					0	0	0	0	T	7577124	T	T	7577124	3	4	103	1	0	0	0	0	1	0	0	0	16448	507	18	4	472	4	TP53	17	7577124	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08		7577124	73618086	107	19601											
ALOXE3	59344	broad.mit.edu	37	chr17	8017844	8017844	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgagatcgtcttggtggctGagtatcgaacattgggctcc	7	11	14	9	3	1	2	0	1	1	1	4	4	2	2	1	3	1	3	1	3	2	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:8017844G>C	uc010cnr.2	-	6	1008	c.638C>G	c.(637-639)TCA>TGA	p.S213*	ALOXE3_uc002gka.2_Nonsense_Mutation_p.S369*|ALOXE3_uc010vuo.1_Nonsense_Mutation_p.S345*|ALOXE3_uc010vup.1_RNA	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	213	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						CTTGGTGGCTGAGTATCGAAC	0.502													21	44					0	0	0	0	C	8017844	C	C	8017844	4	2	103	1	0	0	0	0	0	1	0	0	542	1294	45	2	1541	2	ALOXE3	17	8017844	Nonsense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	440720	8017844	73177366	108	19602											
MYOCD	93649	broad.mit.edu	37	chr17	12655998	12655998	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccccagcctcctctgacCtgtcagtcgctgggtccctg	3	11	9	18	1	3	1	1	1	2	0	7	1	5	1	6	1	1	1	6	1	0	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:12655998C>T	uc002gnn.2	+	10	1692	c.1393C>T	c.(1393-1395)CTG>TTG	p.L465L	MYOCD_uc002gno.2_Silent_p.L465L|MYOCD_uc002gnp.1_Silent_p.L369L|MYOCD_uc002gnq.2_Silent_p.L184L	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	465	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CTCCTCTGACCTGTCAGTCGC	0.612													18	79					0	0	0	0	T	12655998	T	T	12655998	2	4	103	1	0	0	0	0	0	0	0	1	10140	680	24	4		4	MYOCD	17	12655998	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	4638154	12655998	68539212	109	19603											
ULK2	9706	broad.mit.edu	37	chr17	19698941	19698941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tacatttttcttacctatatCcattggtcgttctgtattta	8	21	4	8	1	2	0	0	0	2	0	4	0	3	0	2	1	2	2	2	1	6	11			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:19698941C>G	uc002gwm.3	-	20	2604	c.2095G>C	c.(2095-2097)GAT>CAT	p.D699H	ULK2_uc002gwn.2_Missense_Mutation_p.D699H	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	699					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					TTACCTATATCCATTGGTCGT	0.294													43	65					0	0	0	0	G	19698941	G	G	19698941	3	3	103	1	0	0	0	0	1	0	0	0	17044	855	30	2	1047	2	ULK2	17	19698941	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	7042943	19698941	61496269	110	19604											
ULK2	9706	broad.mit.edu	37	chr17	19699443	19699443	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctctgctgctcggcccgCtgcctctcacttccttgcac	2	13	8	18	2	2	0	1	0	2	0	5	0	3	0	3	1	5	5	3	1	0	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:19699443C>T	uc002gwm.3	-	19	2471	c.1962G>A	c.(1960-1962)CAG>CAA	p.Q654Q	ULK2_uc002gwn.2_Silent_p.Q654Q	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	654					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GCTCGGCCCGCTGCCTCTCAC	0.473													37	47					0	0	0	0	T	19699443	T	T	19699443	2	4	103	1	0	0	0	0	0	0	0	1	17044	796	28	4		4	ULK2	17	19699443	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	502	19699443	61495767	111	19605											
DHRS13	147015	broad.mit.edu	37	chr17	27228113	27228113	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcagcatatgcccgcagctCctgccgccagcccaccactg	7	6	9	19	2	1	0	1	0	0	0	2	0	2	0	6	0	5	3	6	0	1	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:27228113C>A	uc002hde.3	-	4	704	c.577G>T	c.(577-579)GAG>TAG	p.E193*	DHRS13_uc002hdd.3_Nonsense_Mutation_p.E143*|DHRS13_uc010wba.1_Nonsense_Mutation_p.E112*	NM_144683	NP_653284	Q6UX07	DHR13_HUMAN	dehydrogenase/reductase (SDR family) member 13	193						extracellular region	binding|oxidoreductase activity				0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.59e-06)|all cancers(11;9.27e-06)|BRCA - Breast invasive adenocarcinoma(11;5.78e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			GCCCGCAGCTCCTGCCGCCAG	0.632													18	39					4.35082e-09	4.98597e-09	1	0	A	27228113	A	A	27228113	4	1	103	1	0	0	0	0	0	1	0	0	4511	864	30	2	564	2	DHRS13	17	27228113	Nonsense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	7528670	27228113	53967097	112	19606											
MMP28	79148	broad.mit.edu	37	chr17	34093598	34093598	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagcggcccgaggtggttGcctgcagtttggcctggtcg	3	9	16	13	3	0	0	0	0	0	0	1	1	0	0	4	5	3	3	4	5	0	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:34093598G>C	uc002hjy.1	-	10	1743	c.1484C>G	c.(1483-1485)GCA>GGA	p.A495G	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	495	Hemopexin-like 4.				proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CGAGGTGGTTGCCTGCAGTTT	0.662													3	12					0	0	0	0	C	34093598	C	C	34093598	3	2	103	1	0	0	0	0	1	0	0	0	9718	1319	46	4	82	4	MMP28	17	34093598	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	6865485	34093598	47101612	113	19607											
DDX52	11056	broad.mit.edu	37	chr17	35986901	35986901	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgatttggagtagtcacaaGaatatctataggaaaaacaa	18	10	8	5	1	2	1	1	0	1	1	3	4	2	3	0	2	1	1	0	2	9	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:35986901G>C	uc002hoi.1	-	7	903	c.865C>G	c.(865-867)CTT>GTT	p.L289V	DDX52_uc002hoh.1_Missense_Mutation_p.L181V	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a	289	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				GTAGTCACAAGAATATCTATA	0.358													9	34					0	0	0	0	C	35986901	C	C	35986901	3	2	103	1	0	0	0	0	1	0	0	0	4387	942	33	2	970	2	DDX52	17	35986901	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	1893303	35986901	45208309	114	19608											
ZPBP2	124626	broad.mit.edu	37	chr17	38032946	38032946	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cctctgcagtggtttgtagtCctgcgacttttagtcctgat	5	16	10	10	1	1	1	0	1	1	0	3	2	3	1	3	1	2	3	3	1	2	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:38032946C>G	uc002hte.2	+	8	1054	c.901C>G	c.(901-903)CCT>GCT	p.P301A	ZPBP2_uc002htf.2_Missense_Mutation_p.P279A	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	301					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			GGTTTGTAGTCCTGCGACTTT	0.373													24	89					0	0	0	0	G	38032946	G	G	38032946	3	3	103	1	0	0	0	0	1	0	0	0	18287	855	30	2	931	2	ZPBP2	17	38032946	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	2046045	38032946	43162264	115	19609											
KRT10	3858	broad.mit.edu	37	chr17	38976763	38976763	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtataacttttgtgtcacCtcctcgtggttcttcttcag	7	17	7	10	1	4	0	2	0	2	0	6	0	5	0	2	1	1	2	2	1	3	7			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:38976763C>G	uc002hvi.2	-	3	893	c.867G>C	c.(865-867)GAG>GAC	p.E289D	KRT10_uc010cxd.2_5'Flank|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	289	Coil 1B.|Rod.|Gly-rich.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				TTTGTGTCACCTCCTCGTGGT	0.468													9	67					0	0	0	0	G	38976763	G	G	38976763	3	3	103	1	0	0	0	0	1	0	0	0	8487	695	24	4	911	4	KRT10	17	38976763	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	943817	38976763	42218447	116	19610											
FZD2	2535	broad.mit.edu	37	chr17	42636331	42636331	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgctcttcgtgtacctgttCatcggcacgtccttcctcct	3	14	7	17	4	2	0	1	0	1	0	7	0	5	0	5	1	1	4	5	1	1	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:42636331C>G	uc002igx.1	+	1	1407	c.1275C>G	c.(1273-1275)TTC>TTG	p.F425L		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	425	Helical; Name=5; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGTACCTGTTCATCGGCACGT	0.637													12	51					0	0	0	0	G	42636331	G	G	42636331	3	3	103	1	0	0	0	0	1	0	0	0	6164	825	29	2	1277	2	FZD2	17	42636331	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	3659568	42636331	38558879	117	19611											
INTS2	57508	broad.mit.edu	37	chr17	59962319	59962319	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggaatttgataggaatctGatccattaaagaagaagaat	19	10	9	3	0	1	5	0	2	1	3	2	7	2	7	1	2	0	0	1	2	9	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:59962319G>C	uc002izn.2	-	16	2132	c.2056C>G	c.(2056-2058)CAG>GAG	p.Q686E	INTS2_uc002izm.2_Missense_Mutation_p.Q678E	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	686					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						ATAGGAATCTGATCCATTAAA	0.333													7	7					0	0	0	0	C	59962319	C	C	59962319	3	2	103	1	0	0	0	0	1	0	0	0	7817	1299	45	2	1598	2	INTS2	17	59962319	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	17325988	59962319	21232891	118	19612											
SGSH	6448	broad.mit.edu	37	chr17	78184560	78184560	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtgagacgtagaagtcCtggtcgatgggaaagggcat	10	8	18	5	2	0	2	0	1	0	2	2	5	1	3	1	4	0	2	1	4	3	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:78184560C>T	uc002jxz.3	-	8	1287	c.1200G>A	c.(1198-1200)CAG>CAA	p.Q400Q	SGSH_uc002jya.3_Silent_p.Q197Q|SGSH_uc002jxy.2_3'UTR	NM_000199	NP_000190	P51688	SPHM_HUMAN	N-sulfoglucosamine sulfohydrolase precursor	400					proteoglycan metabolic process	lysosome	metal ion binding|N-sulfoglucosamine sulfohydrolase activity|sulfuric ester hydrolase activity			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CGTAGAAGTCCTGGTCGATGG	0.602													25	46					0	0	0	0	T	78184560	T	T	78184560	2	4	103	1	0	0	0	0	0	0	0	1	14286	680	24	4		4	SGSH	17	78184560	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	18222241	78184560	3010650	119	19613											
FBN3	84467	broad.mit.edu	37	chr19	8154783	8154783	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgaggggctcaccttctCgggagtcatccgggcctggg	4	8	18	11	2	3	1	2	1	1	0	5	2	4	2	3	6	0	1	3	6	0	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:8154783C>A	uc002mjf.2	-	49	6266	c.6245G>T	c.(6244-6246)CGA>CTA	p.R2082L	FBN3_uc002mje.2_5'UTR	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2082						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CTCACCTTCTCGGGAGTCATC	0.647													5	3					1.23904e-05	1.3509e-05	1	0	A	8154783	A	A	8154783	3	1	103	1	0	0	0	0	1	0	0	0	5736	884	31	3	2244	3	FBN3	19	8154783	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08		8154783	50974200	120	19614											
CACNA1A	773	broad.mit.edu	37	chr19	13409899	13409899	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctcggcgcgctgctggcCgaggcgctggtccacggtgg	2	7	18	14	6	0	0	0	0	0	0	3	1	2	0	3	6	1	3	3	6	0	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:13409899C>T	uc010dze.2	-	19	2787	c.2551G>A	c.(2551-2553)GGC>AGC	p.G851S	CACNA1A_uc010dzc.2_Missense_Mutation_p.G376S|CACNA1A_uc002mwy.3_Missense_Mutation_p.G850S|CACNA1A_uc010xne.1_Missense_Mutation_p.G379S	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	851	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGCTGCTGGCCGAGGCGCTGG	0.721													10	10					0	0	0	0	T	13409899	T	T	13409899	3	4	103	1	0	0	0	0	1	0	0	0	2550	652	23	1	5190	1	CACNA1A	19	13409899	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	5255116	13409899	45719084	121	19615											
BRD4	23476	broad.mit.edu	37	chr19	15355574	15355574	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttgacttcggagccatctCtgcagaggaaaagagaaggt	12	10	12	7	1	1	3	0	1	1	2	3	6	1	5	1	3	2	1	1	3	3	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:15355574C>T	uc002nar.2	-	12	2381	c.2159_splice	c.e12-1	p.E720_splice		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long						interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GGAGCCATCTCTGCAGAGGAA	0.547			T	NUT|C15orf55	lethal midline carcinoma of young people								37	75					0	0	0	0	T	15355574	T	T	15355574	5	4	103	1	0	0	0	0	0	0	1	0	1509	927	32	2	1966	2	BRD4	19	15355574	Splice_Site	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	1945675	15355574	43773409	122	19616											
ZNF382	84911	broad.mit.edu	37	chr19	37117054	37117054	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagatgggaaaactgaagaTgtcttagtgaagttcaaaga	17	9	12	3	0	2	5	1	2	1	3	2	7	2	6	0	1	1	1	0	1	7	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:37117054T>C	uc002oek.2	+	5	368	c.255T>C	c.(253-255)GAT>GAC	p.D85D	ZNF382_uc010efa.2_Silent_p.D36D|ZNF382_uc010efb.2_Silent_p.D84D|ZNF382_uc002oel.2_Silent_p.D84D	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	85	Mediates interaction with TRIM28 (By similarity).|Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AAACTGAAGATGTCTTAGTGA	0.343													16	36					0	0	0	0	C	37117054	C	C	37117054	2	2	103	1	0	0	0	0	0	0	0	1	17940	1461	51	5		5	ZNF382	19	37117054	Silent	SNP	T	TCGA-CQ-6221-01A-11D-2078-08	21761480	37117054	22011929	123	19617											
EPN1	29924	broad.mit.edu	37	chr19	56203256	56203256	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacccctggggcggcccccCtgtccctccagctgctgatc	3	7	12	19	1	0	1	0	1	0	0	3	2	2	2	7	4	2	2	7	4	0	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:56203256C>T	uc002qlw.2	+	7	1241	c.899C>T	c.(898-900)CCT>CTT	p.P300L	EPN1_uc002qlv.2_Missense_Mutation_p.P275L|EPN1_uc010etd.2_Missense_Mutation_p.P300L|EPN1_uc002qlx.2_Missense_Mutation_p.P386L	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	300	Ala/Gly/Pro-rich.|8 X 3 AA repeats of [ED]-P-W.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		GGCGGCCCCCCTGTCCCTCCA	0.751													12	37					0	0	0	0	T	56203256	T	T	56203256	3	4	103	1	0	0	0	0	1	0	0	0	5209	681	24	4	1262	4	EPN1	19	56203256	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	19086202	56203256	2925727	124	19618											
ZNF324B	388569	broad.mit.edu	37	chr19	58965127	58965127	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtgggggctcctggacaCagcgcagagggccctgtacc	7	5	17	12	1	0	1	0	0	0	1	1	3	1	3	3	5	2	3	3	5	1	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:58965127C>G	uc002qsv.1	+	2	166	c.59C>G	c.(58-60)ACA>AGA	p.T20R	ZNF324B_uc002qsu.1_5'UTR|ZNF324B_uc010euq.1_Missense_Mutation_p.T20R	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CTCCTGGACACAGCGCAGAGG	0.572													21	49					0	0	0	0	G	58965127	G	G	58965127	3	3	103	1	0	0	0	0	1	0	0	0	17912	478	17	4	61	4	ZNF324B	19	58965127	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	2761871	58965127	163856	125	19619											
C20orf117	140710	broad.mit.edu	37	chr20	35444329	35444329	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctctgccaagctctcccCgcactctccgccacccagcg	6	6	7	22	3	3	0	0	0	3	0	5	0	3	0	6	0	4	3	6	0	1	0			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr20:35444329C>G	uc002xgd.1	-	5	1129	c.802G>C	c.(802-804)GGG>CGG	p.G268R	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	268											0		Myeloproliferative disorder(115;0.00874)				AAGCTCTCCCCGCACTCTCCG	0.662													4	5					0	0	0	0	G	35444329	G	G	35444329	3	3	103	1	0	0	0	0	1	0	0	0	2093	652	23	3	3575	3	C20orf117	20	35444329	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08		35444329	27581191	126	19620											
PRDM15	63977	broad.mit.edu	37	chr21	43258051	43258051	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggacttactttggaacCgagctggtgtcagtggtggt	7	11	16	7	1	1	0	1	0	0	0	1	3	1	2	1	6	3	2	1	6	2	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr21:43258051C>T	uc002yzq.1	-	15	2202	c.2091G>A	c.(2089-2091)TCG>TCA	p.S697S	PRDM15_uc002yzo.2_Silent_p.S368S|PRDM15_uc002yzp.2_Silent_p.S368S|PRDM15_uc002yzr.1_Silent_p.S368S	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	697					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTTTGGAACCGAGCTGGTGT	0.627													23	52					0	0	0	0	T	43258051	T	T	43258051	2	4	103	1	0	0	0	0	0	0	0	1	12518	639	23	1		1	PRDM15	21	43258051	Silent	SNP	C	TCGA-CQ-6221-01A-11D-2078-08		43258051	4871844	127	19621											
POTEH	23784	broad.mit.edu	37	chr22	16279217	16279217	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccatatctatccagtgcatTtaaatttgcttttttcttga	9	20	4	8	0	2	1	0	1	2	0	4	1	4	1	2	0	2	2	2	0	4	9			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr22:16279217T>A	uc010gqp.2	-	4	1058	c.1006A>T	c.(1006-1008)AAT>TAT	p.N336Y	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.N55Y|POTEH_uc002zlj.1_Missense_Mutation_p.N171Y	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	336	ANK 5.									skin(1)	1						TCCAGTGCATTTAAATTTGCT	0.313													29	221					0	0	0	0	A	16279217	A	A	16279217	3	1	103	1	0	0	0	0	1	0	0	0	12322	1841	64	5	659	5	POTEH	22	16279217	Missense_Mutation	SNP	T	TCGA-CQ-6221-01A-11D-2078-08		16279217	35025349	128	19622											
ZDHHC8	29801	broad.mit.edu	37	chr22	20130547	20130547	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacgccccaccgtagcatttTtgccccccatgcactgccca	7	8	6	20	2	0	0	0	0	0	0	0	0	0	0	7	0	4	3	7	0	1	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr22:20130547T>C	uc002zrq.2	+	10	1500	c.1394T>C	c.(1393-1395)TTT>TCT	p.F465S	ZDHHC8_uc002zrr.1_Missense_Mutation_p.F465S|ZDHHC8_uc010gsa.2_Missense_Mutation_p.F271S	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	465	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					CGTAGCATTTTTGCCCCCCAT	0.701													6	62					0	0	0	0	C	20130547	C	C	20130547	3	2	103	1	0	0	0	0	1	0	0	0	17688	1841	64	5	1432	5	ZDHHC8	22	20130547	Missense_Mutation	SNP	T	TCGA-CQ-6221-01A-11D-2078-08	3851330	20130547	31174019	129	19623											
LIF	3976	broad.mit.edu	37	chr22	30639706	30639706	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggagttgacagcccagcttCttcttctggaagacatcctt	9	12	9	11	0	3	2	0	1	3	1	4	4	4	4	2	2	2	2	2	2	1	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr22:30639706C>G	uc003agz.2	-	3	655	c.543G>C	c.(541-543)AAG>AAC	p.K181N	LIF_uc011aks.1_3'UTR|uc003aha.2_5'Flank	NM_002309	NP_002300	P15018	LIF_HUMAN	leukemia inhibitory factor (cholinergic	181					immune response|leukemia inhibitory factor signaling pathway|negative regulation of hormone secretion|positive regulation of cell proliferation|positive regulation of macrophage differentiation|positive regulation of MAPKKK cascade|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of metanephric nephron tubule epithelial cell differentiation		cytokine activity|growth factor activity|leukemia inhibitory factor receptor binding				0			Epithelial(10;0.171)			AGCCCAGCTTCTTCTTCTGGA	0.572													30	87					0	0	0	0	G	30639706	G	G	30639706	3	3	103	1	0	0	0	0	1	0	0	0	8820	912	32	2	69	2	LIF	22	30639706	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	10509159	30639706	20664860	130	19624											
GGA1	26088	broad.mit.edu	37	chr22	38016337	38016337	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgcccgaggaggtgaaaatCgcagaggcctaccagatgct	11	6	13	11	2	0	3	0	1	0	2	1	5	0	4	3	3	3	2	3	3	3	1			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr22:38016337C>G	uc003atc.2	+	5	761	c.396C>G	c.(394-396)ATC>ATG	p.I132M	GGA1_uc003atd.2_Missense_Mutation_p.I132M|GGA1_uc003ate.2_Missense_Mutation_p.I132M|GGA1_uc003atf.2_Missense_Mutation_p.I59M	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	132	Interaction with ARF3.|VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					AGGTGAAAATCGCAGAGGCCT	0.612													24	84					0	0	0	0	G	38016337	G	G	38016337	3	3	103	1	0	0	0	0	1	0	0	0	6389	874	31	3	480	3	GGA1	22	38016337	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	7376631	38016337	13288229	131	19625											
CSNK1E	1454	broad.mit.edu	37	chr22	38694865	38694865	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaggttgcggaagagctGacgtaggtaagagtagtcgg	12	7	18	4	3	0	4	0	1	0	3	1	6	0	5	0	4	2	5	0	4	5	4			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr22:38694865G>C	uc003avj.2	-	7	1072	c.811C>G	c.(811-813)CAG>GAG	p.Q271E	CSNK1E_uc003avk.2_Missense_Mutation_p.Q271E|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Missense_Mutation_p.Q271E|CSNK1E_uc003avo.2_Missense_Mutation_p.Q271E|CSNK1E_uc003avp.1_Missense_Mutation_p.Q271E|CSNK1E_uc003avq.1_Missense_Mutation_p.Q271E	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	271	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)					CGGAAGAGCTGACGTAGGTAA	0.547											OREG0026559	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	122					0	0	0	0	C	38694865	C	C	38694865	3	2	103	1	0	0	0	0	1	0	0	0	3970	1299	45	2	455	2	CSNK1E	22	38694865	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	678528	38694865	12609701	132	19626											
FAM123B	139285	broad.mit.edu	37	chrX	63412439	63412439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagctggtggagaaggttctGgtgttggagaaacttttggc	8	13	16	4	0	1	2	0	0	1	2	1	4	1	2	0	6	2	3	0	6	3	5			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chrX:63412439G>A	uc004dvo.2	-	2	1001	c.728C>T	c.(727-729)CCA>CTA	p.P243L		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	243					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						AGAAGGTTCTGGTGTTGGAGA	0.542													47	30					0	0	0	0	A	63412439	A	A	63412439	3	1	103	1	0	0	0	0	1	0	0	0	5451	1348	47	4	2683	4	FAM123B	23	63412439	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08		63412439	91858121	133	19627											
MED12	9968	broad.mit.edu	37	chrX	70338616	70338616	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgggcaagatggcggccttCgggatcttgagctacgaaca	9	8	14	10	3	1	2	0	1	1	1	2	4	1	3	1	4	3	2	1	4	3	3			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chrX:70338616C>G	uc004dyy.2	+	1	211	c.12C>G	c.(10-12)TTC>TTG	p.F4L	MED12_uc011mpq.1_Missense_Mutation_p.F4L|MED12_uc004dyz.2_Missense_Mutation_p.F4L|MED12_uc004dza.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	4					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGGCGGCCTTCGGGATCTTGA	0.672													8	4					0	0	0	0	G	70338616	G	G	70338616	3	3	103	1	0	0	0	0	1	0	0	0	9481	883	31	3	14	3	MED12	23	70338616	Missense_Mutation	SNP	C	TCGA-CQ-6221-01A-11D-2078-08	6926177	70338616	84931944	134	19628											
MID2	11043	broad.mit.edu	37	chrX	107084609	107084609	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgaatgatcgatttgagaaActcaaggtaagggatctggg	13	10	13	5	1	2	3	1	3	1	1	3	6	2	4	0	3	1	1	0	3	4	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chrX:107084609A>G	uc004enl.2	+	2	1287	c.714A>G	c.(712-714)AAA>AAG	p.K238K	MID2_uc004enk.2_Silent_p.K238K	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	238	Potential.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						GATTTGAGAAACTCAAGGTAA	0.433													13	14					0	0	0	0	G	107084609	G	G	107084609	2	3	103	1	0	0	0	0	0	0	0	1	9631	40	2	5		5	MID2	23	107084609	Silent	SNP	A	TCGA-CQ-6221-01A-11D-2078-08	36745993	107084609	48185951	135	19629											
FRMD7	90167	broad.mit.edu	37	chrX	131212868	131212868	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctggtttggaatgctccaGctcagttgcaaatgtcacct	8	13	9	11	0	3	0	2	0	1	0	4	1	4	1	2	2	3	5	2	2	2	2			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chrX:131212868G>C	uc004ewn.2	-	12	1355	c.1177C>G	c.(1177-1179)CTG>GTG	p.L393V	FRMD7_uc011muy.1_Missense_Mutation_p.L378V	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	393					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GAatgctccagctcagttgca	0.284													71	38					0	0	0	0	C	131212868	C	C	131212868	3	2	103	1	0	0	0	0	1	0	0	0	6089	962	34	4	971	4	FRMD7	23	131212868	Missense_Mutation	SNP	G	TCGA-CQ-6221-01A-11D-2078-08	24128259	131212868	24057692	136	19630											
LIN28A	79727	broad.mit.edu	37	chr1	26751932	26751932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtattgggagtgagaggCggccaaaaggaaagagcatg	13	7	16	5	1	1	2	0	1	1	2	1	5	1	4	1	4	1	2	1	4	4	2			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:26751932C>T	uc001bmj.2	+	3	481	c.367C>T	c.(367-369)CGG>TGG	p.R123W	LIN28A_uc001bmi.1_RNA	NM_024674	NP_078950	Q9H9Z2	LN28A_HUMAN	lin-28 homolog	123					miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)	1						GAGTGAGAGGCGGCCAAAAGG	0.522													9	108					0	0	0	0	T	26751932	T	T	26751932	3	4	104	1	0	0	0	0	1	0	0	0	8847	759	27	1	377	1	LIN28A	1	26751932	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08		26751932	222498689	1	19631											
PUM1	9698	broad.mit.edu	37	chr1	31437649	31437650	+	Frame_Shift_Ins	INS	-	A	A																															ggaaaagctaaggccgttatINSaaaaactgtgtccaatgggg																										TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:31437649_31437650insA	uc001bsi.1	-	14	2307_2308	c.2194_2195insT	c.(2194-2196)TATfs	p.Y732fs	PUM1_uc001bsf.1_Frame_Shift_Ins_p.Y398fs|PUM1_uc001bsg.1_Intron|PUM1_uc001bsh.1_Frame_Shift_Ins_p.Y732fs|PUM1_uc001bsj.1_Frame_Shift_Ins_p.Y706fs|PUM1_uc010oga.1_Frame_Shift_Ins_p.Y588fs|PUM1_uc001bsk.1_Frame_Shift_Ins_p.Y768fs|PUM1_uc010ogb.1_Frame_Shift_Ins_p.Y673fs	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	732	Ser-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		AAGGCCGTTATAAAAACTGTGT	0.559													---	---	---								A	31437650	A	A	31437649	7	5	104	1	0	1	1	0	0	0	0	0	12890	1406	49	0	1407	0	PUM1	1	31437649	Frame_Shift_Ins	INS	-	TCGA-CQ-6222-01A-11D-1912-08	4685717	31437649	217812972	2	19632											
GSTM2	2946	broad.mit.edu	37	chr1	110211933	110211933	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccctacttgattgatgggActcacaagatcacccagagc	11	9	9	12	0	2	4	2	2	0	2	2	5	2	5	2	1	3	0	2	1	2	3	rs2227960	byFrequency	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:110211933A>G	uc001dyi.2	+	4	513	c.199A>G	c.(199-201)ACT>GCT	p.T67A	GSTM2_uc001dyj.2_Missense_Mutation_p.T67A|GSTM2_uc010ovt.1_Missense_Mutation_p.T67A|GSTM2_uc009wfk.2_RNA	NM_000848	NP_000839	P28161	GSTM2_HUMAN	glutathione S-transferase mu 2 isoform 1	67	GST N-terminal.				glutathione metabolic process|xenobiotic catabolic process	cytoplasm	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	GATTGATGGGACTCACAAGAT	0.572													23	221					0	0	0	0	G	110211933	G	G	110211933	3	3	104	1	0	0	0	0	1	0	0	0	6877	275	10	5	213	5	GSTM2	1	110211933	Missense_Mutation	SNP	A	TCGA-CQ-6222-01A-11D-1912-08	78774284	110211933	139038688	3	19633											
C1orf103	55791	broad.mit.edu	37	chr1	111494604	111494604	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taacaggaacaagagatggcGtaaaaggctgtagattatct	16	9	11	5	1	1	2	0	0	1	2	1	4	1	3	0	3	2	3	0	3	7	4			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:111494604G>A	uc001eaa.2	-	2	1158	c.902C>T	c.(901-903)ACG>ATG	p.T301M	C1orf103_uc001dzz.2_Intron|C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		AAGAGATGGCGTAAAAGGCTG	0.343													6	66					0	0	0	0	A	111494604	A	A	111494604	3	1	104	1	0	0	0	0	1	0	0	0	1986	1145	40	1	1419	1	C1orf103	1	111494604	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	1282671	111494604	137756017	4	19634											
REG4	83998	broad.mit.edu	37	chr1	120337248	120337248	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgattcttgctctatggtCggtacttgcacaggaagtgt	7	15	11	8	1	2	1	0	1	2	0	3	2	2	2	0	3	3	3	0	3	3	6			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:120337248C>T	uc001eig.2	-	7	910	c.470G>A	c.(469-471)CGA>CAA	p.R157Q	REG4_uc001eif.2_Missense_Mutation_p.R157Q	NM_001159352	NP_001152824	Q9BYZ8	REG4_HUMAN	regenerating islet-derived family, member 4	157						extracellular region	sugar binding	p.R157*(1)		ovary(1)	1	all_cancers(5;4.81e-10)|all_epithelial(5;7.98e-11)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;8.1e-07)|Lung NSC(69;5.89e-06)|all_epithelial(167;0.000959)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0588)		GCTCTATGGTCGGTACTTGCA	0.428													14	195					0	0	0	0	T	120337248	T	T	120337248	3	4	104	1	0	0	0	0	1	0	0	0	13279	884	31	1	10	1	REG4	1	120337248	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08	8842644	120337248	128913373	5	19635											
VPS72	6944	broad.mit.edu	37	chr1	151156861	151156861	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcctcctgggttagtggcCgctcacagtggggccccttt	3	12	13	13	1	1	0	1	0	0	0	3	0	3	0	5	4	0	3	5	4	1	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:151156861C>T	uc001exe.1	-	4	537	c.494G>A	c.(493-495)CGG>CAG	p.R165Q	VPS72_uc001exf.1_Missense_Mutation_p.R165Q	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	165	Potential.				chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGTTAGTGGCCGCTCACAGTG	0.537													12	157					0	0	0	0	T	151156861	T	T	151156861	3	4	104	1	0	0	0	0	1	0	0	0	17285	652	23	1	612	1	VPS72	1	151156861	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08	30819613	151156861	98093760	6	19636											
LCE2D	353141	broad.mit.edu	37	chr1	152636834	152636834	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgtctcttccaccggcgcCggcaccagagccccgattgc	5	6	10	20	5	1	1	0	0	1	1	3	2	2	1	7	2	2	1	7	2	0	2			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:152636834C>T	uc001fag.2	+	2	308	c.253C>T	c.(253-255)CGG>TGG	p.R85W		NM_178430	NP_848517	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	85	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCACCGGCGCCGGCACCAGAG	0.682													8	86					0	0	0	0	T	152636834	T	T	152636834	3	4	104	1	0	0	0	0	1	0	0	0	8708	643	23	1	255	1	LCE2D	1	152636834	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08	1479973	152636834	96613787	7	19637											
KCNH1	3756	broad.mit.edu	37	chr1	210857106	210857106	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttgcgcttggcacaatcGcccccgccccccttggggcc	3	9	10	19	3	0	0	0	0	0	0	1	0	0	0	6	3	1	2	6	3	1	4			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:210857106G>A	uc001hib.2	-	11	2657	c.2487C>T	c.(2485-2487)GGC>GGT	p.G829G	KCNH1_uc001hic.2_Silent_p.G802G	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	829	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TGGCACAATCGCCCCCGCCCC	0.642													13	89					0	0	0	0	A	210857106	A	A	210857106	2	1	104	1	0	0	0	0	0	0	0	1	8070	1074	38	1		1	KCNH1	1	210857106	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	58220272	210857106	38393515	8	19638											
AKT3	10000	broad.mit.edu	37	chr1	243736284	243736284	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atagtccaaggcagagacaaTttctgcaccatagaaacgtg	15	8	9	9	1	1	2	0	0	1	2	2	3	2	2	2	1	2	2	2	1	5	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:243736284T>C	uc001iab.1	-	8	844	c.763A>G	c.(763-765)ATT>GTT	p.I255V	AKT3_uc001hzz.1_Missense_Mutation_p.I255V	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	255	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GCAGAGACAATTTCTGCACCA	0.413													12	40					0	0	0	0	C	243736284	C	C	243736284	3	2	104	1	0	0	0	0	1	0	0	0	481	1493	52	5	748	5	AKT3	1	243736284	Missense_Mutation	SNP	T	TCGA-CQ-6222-01A-11D-1912-08	32879178	243736284	5514337	9	19639											
PSME4	23198	broad.mit.edu	37	chr2	54119989	54119989	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctctgattaaaccagctaTaatttctgcaacacatcgct	13	12	4	12	1	2	1	0	1	2	0	3	1	2	1	2	0	4	3	2	0	5	4			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:54119989T>C	uc002rxp.2	-	36	4203	c.4147A>G	c.(4147-4149)ATA>GTA	p.I1383V	PSME4_uc010yop.1_Missense_Mutation_p.I1269V|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Missense_Mutation_p.I758V|PSME4_uc010fbv.1_Missense_Mutation_p.I527V	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1383	HEAT 4.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AAACCAGCTATAATTTCTGCA	0.383													4	69					0	0	0	0	C	54119989	C	C	54119989	3	2	104	1	0	0	0	0	1	0	0	0	12771	1406	49	5	1428	5	PSME4	2	54119989	Missense_Mutation	SNP	T	TCGA-CQ-6222-01A-11D-1912-08		54119989	189079384	10	19640											
RGPD4	285190	broad.mit.edu	37	chr2	108488296	108488297	+	Frame_Shift_Ins	INS	-	A	A																															ttggcaagtagccctgtgagINSaaaaaatcttttccattttg																										TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:108488296_108488297insA	uc010ywk.1	+	20	3918_3919	c.3836_3837insA	c.(3835-3837)AGAfs	p.R1279fs	RGPD4_uc002tdu.2_Frame_Shift_Ins_p.R466fs|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1279					intracellular transport		binding			skin(2)	2						AGCCCTGTGAGAAAAAATCTTT	0.396													---	---	---								A	108488297	A	A	108488296	7	5	104	1	0	1	1	0	0	0	0	0	13353	942	33	0	3914	0	RGPD4	2	108488296	Frame_Shift_Ins	INS	-	TCGA-CQ-6222-01A-11D-1912-08	54368307	108488296	134711077	11	19641											
MARCO	8685	broad.mit.edu	37	chr2	119726797	119726797	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgtggtggtcatctacctGatcctgctcaccgctggcgc	4	11	12	14	2	3	1	2	1	1	0	4	1	4	1	3	3	2	3	3	3	1	1			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:119726797G>A	uc002tln.1	+	2	291	c.159G>A	c.(157-159)CTG>CTA	p.L53L	MARCO_uc010yyf.1_5'UTR	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	53	Helical; Signal-anchor for type II membrane protein; (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TCATCTACCTGATCCTGCTCA	0.597													9	73					0	0	0	0	A	119726797	A	A	119726797	2	1	104	1	0	0	0	0	0	0	0	1	9364	1277	45	2		2	MARCO	2	119726797	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	11238501	119726797	123472576	12	19642											
RAB3GAP1	22930	broad.mit.edu	37	chr2	135920601	135920601	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggaagctctcattgccagaGctcggtcactaaaagccaag	12	8	10	11	1	2	1	2	0	1	1	4	2	2	2	2	2	4	2	2	2	4	2			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:135920601G>T	uc002tuj.2	+	22	2561	c.2536G>T	c.(2536-2538)GCT>TCT	p.A846S	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.A846S|RAB3GAP1_uc010fng.2_Missense_Mutation_p.A671S|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	846						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		CATTGCCAGAGCTCGGTCACT	0.423													11	110					7.03913e-09	3.97945e-08	1	0	T	135920601	T	T	135920601	3	4	104	1	0	0	0	0	1	0	0	0	13000	971	34	4	2622	4	RAB3GAP1	2	135920601	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	16193804	135920601	107278772	13	19643											
MYL1	4632	broad.mit.edu	37	chr2	211179749	211179749	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccacaggtttcttcacGtctttctttggtgccatttt	5	17	8	11	1	4	0	1	0	3	0	4	0	4	0	2	2	2	2	2	2	0	6			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:211179749G>A	uc002vec.2	-	1	147	c.18C>T	c.(16-18)GAC>GAT	p.D6D		NM_079420	NP_524144	P05976	MYL1_HUMAN	fast skeletal myosin alkali light chain 1	6					muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			ovary(1)	1				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GTTTCTTCACGTCTTTCTTTG	0.323													29	234					0	0	0	0	A	211179749	A	A	211179749	2	1	104	1	0	0	0	0	0	0	0	1	10096	1136	40	1		1	MYL1	2	211179749	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	75259148	211179749	32019624	14	19644											
ANKZF1	55139	broad.mit.edu	37	chr2	220098566	220098566	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agggagcacccctgcaaaggGgggatccccgactttgggat	9	6	15	11	1	0	0	0	0	0	0	1	4	1	3	4	5	2	2	4	5	1	1			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:220098566G>A	uc002vkg.2	+	8	1123	c.949G>A	c.(949-951)GGG>AGG	p.G317R	ANKZF1_uc010zkv.1_Missense_Mutation_p.G261R|ANKZF1_uc010zkw.1_Missense_Mutation_p.G107R|ANKZF1_uc002vkh.2_Missense_Mutation_p.G107R|ANKZF1_uc002vki.2_Missense_Mutation_p.G317R|ANKZF1_uc002vkj.1_Missense_Mutation_p.G305R	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	317						intracellular	zinc ion binding	p.G317V(1)		ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTGCAAAGGGGGGATCCCCG	0.597													7	60					0	0	0	0	A	220098566	A	A	220098566	3	1	104	1	0	0	0	0	1	0	0	0	693	1232	43	4	975	4	ANKZF1	2	220098566	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	8918817	220098566	23100807	15	19645											
GLB1	2720	broad.mit.edu	37	chr3	33038739	33038739	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggtgatggtgtttggggccGaggtcatcaggatgtgctgg	5	11	19	6	2	2	1	2	1	0	0	2	3	2	2	1	7	1	2	1	7	0	1			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr3:33038739G>A	uc003cfi.1	-	16	1949	c.1832C>T	c.(1831-1833)TCG>TTG	p.S611L	GLB1_uc003cfh.1_Missense_Mutation_p.S581L|GLB1_uc003cfj.1_Missense_Mutation_p.S480L|GLB1_uc011axk.1_Missense_Mutation_p.S659L	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	611					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				GTTTGGGGCCGAGGTCATCAG	0.572													7	66					0	0	0	0	A	33038739	A	A	33038739	3	1	104	1	0	0	0	0	1	0	0	0	6464	1059	37	1	205	1	GLB1	3	33038739	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08		33038739	164983691	16	19646											
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	17	7	10	7	0	1	2	1	2	0	0	1	4	1	3	0	3	3	2	0	3	5	0	rs121913279		TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	50					0	0	0	0	G	178952085	G	G	178952085	3	3	104	1	0	0	0	0	1	0	0	0	11968	217	8	5	3218	5	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-CQ-6222-01A-11D-1912-08	145913346	178952085	19070345	17	19647											
MUC4	4585	broad.mit.edu	37	chr3	195517442	195517442	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgttgagggtgttgatttGagatactctggtggtctcca	6	15	15	5	0	2	3	0	3	2	1	3	4	2	3	1	4	1	2	1	4	1	4			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr3:195517442G>C	uc011bto.1	-	2	1469	c.1009C>G	c.(1009-1011)CAA>GAA	p.Q337E	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.Q219E	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	342					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTGTTGATTTGAGATACTCTG	0.458													17	215					0	0	0	0	C	195517442	C	C	195517442	3	2	104	1	0	0	0	0	1	0	0	0	10031	1299	45	2		2	MUC4	3	195517442	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	16565357	195517442	2504988	18	19648											
DRD5	1816	broad.mit.edu	37	chr4	9784380	9784380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccgttgccatcatgatcGtgacctacacgcgcatctac	8	10	7	16	4	2	2	1	2	1	0	4	2	3	2	4	0	3	2	4	0	2	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr4:9784380G>A	uc003gmb.3	+	1	1123	c.727G>A	c.(727-729)GTG>ATG	p.V243M		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	243	Helical; Name=5; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CATCATGATCGTGACCTACAC	0.607													8	45					0	0	0	0	A	9784380	A	A	9784380	3	1	104	1	0	0	0	0	1	0	0	0	4782	1145	40	1	729	1	DRD5	4	9784380	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08		9784380	181369896	19	19649											
FAT1	2195	broad.mit.edu	37	chr4	187560905	187560905	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgttcatcttgctgttctcGgtctagcttccttgacgtag	4	17	10	10	2	4	1	1	1	3	0	6	1	5	1	1	1	2	5	1	1	2	7			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr4:187560905G>A	uc003izf.2	-	4	3801	c.3613C>T	c.(3613-3615)CGA>TGA	p.R1205*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1205	Extracellular (Potential).|Cadherin 10.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGCTGTTCTCGGTCTAGCTTC	0.308										HNSCC(5;0.00058)			12	76					0	0	0	0	A	187560905	A	A	187560905	4	1	104	1	0	0	0	0	0	1	0	0	5721	1124	39	1	10249	1	FAT1	4	187560905	Nonsense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	177776525	187560905	3593371	20	19650											
PARP8	79668	broad.mit.edu	37	chr5	50057654	50057654	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcttactttattattttaaGgaatcaagacagaatagtac	15	16	5	5	0	2	2	1	0	1	2	2	3	2	3	0	1	2	1	0	1	9	9			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr5:50057654G>T	uc003jon.3	+	7	528	c.346_splice	c.e7-1	p.E116_splice	PARP8_uc011cpz.1_Splice_Site_p.E8_splice|PARP8_uc003joo.2_Splice_Site_p.E116_splice|PARP8_uc003jop.2_Splice_Site_p.E116_splice	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				ATTATTTTAAGGAATCAAGAC	0.333													6	62					2.0095e-06	1.09234e-05	1	0	T	50057654	T	T	50057654	5	4	104	1	0	0	0	0	0	0	1	0	11519	1014	35	4	367	4	PARP8	5	50057654	Splice_Site	SNP	G	TCGA-CQ-6222-01A-11D-1912-08		50057654	130857606	21	19651											
SLC36A1	206358	broad.mit.edu	37	chr5	150867642	150867642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcatcatcccaccgctcctgGaggtcaccaccttctactca	8	10	5	18	1	5	0	4	0	1	0	7	1	7	1	5	2	1	1	5	2	1	2			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr5:150867642G>A	uc003luc.2	+	11	1475	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K	GM2A_uc011dcs.1_Intron	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	420	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	ACCGCTCCTGGAGGTCACCAC	0.627													4	38					0	0	0	0	A	150867642	A	A	150867642	3	1	104	1	0	0	0	0	1	0	0	0	14657	1175	41	2	1296	2	SLC36A1	5	150867642	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	100809988	150867642	30047618	22	19652											
FAT2	2196	broad.mit.edu	37	chr5	150921902	150921902	+	Frame_Shift_Del	DEL	T	-	-																															aaatgtcagcatccagggtcTttagagtcgccaccagttcg																										TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr5:150921902delT	uc003lue.3	-	9	8799	c.8786delA	c.(8785-8787)AAGfs	p.K2929fs	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2929	Extracellular (Potential).|Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCCAGGGTCTTTAGAGTCGC	0.493													---	---	---								-	150921902	-	-	150921902	7	5	104	1	0	1	0	1	0	0	0	0	5722	1609	56	0	4323	0	FAT2	5	150921902	Frame_Shift_Del	DEL	T	TCGA-CQ-6222-01A-11D-1912-08	54260	150921902	29993358	23	19653											
EEF1E1	9521	broad.mit.edu	37	chr6	8080226	8080226	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacaaaaccagcgagacacaTtaagatatttctccttttct	14	12	5	10	1	2	2	0	0	2	2	3	4	2	2	2	0	2	0	2	0	4	5			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:8080226T>C	uc003mxz.2	-	4	496	c.422A>G	c.(421-423)AAT>AGT	p.N141S	EEF1E1_uc011dic.1_Intron	NM_004280	NP_004271	O43324	MCA3_HUMAN	eukaryotic translation elongation factor 1	141	GST C-terminal.				negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of DNA damage response, signal transduction by p53 class mediator|tRNA aminoacylation for protein translation	cytosol|nucleus					0	Ovarian(93;0.0398)					GCGAGACACATTAAGATATTT	0.368													3	70					0	0	0	0	C	8080226	C	C	8080226	3	2	104	1	0	0	0	0	1	0	0	0	4949	1493	52	5	146	5	EEF1E1	6	8080226	Missense_Mutation	SNP	T	TCGA-CQ-6222-01A-11D-1912-08		8080226	163034841	24	19654											
HIVEP1	3096	broad.mit.edu	37	chr6	12161735	12161735	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagaatctgatggcccagAtgaggatgacaatgaaaatg	16	8	12	5	0	1	7	0	5	1	2	1	8	1	8	1	2	0	0	1	2	5	0			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:12161735A>G	uc003nac.2	+	8	6730	c.6551A>G	c.(6550-6552)GAT>GGT	p.D2184G	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2184					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GATGGCCCAGATGAGGATGAC	0.453													9	74					0	0	0	0	G	12161735	G	G	12161735	3	3	104	1	0	0	0	0	1	0	0	0	7225	333	12	5	6577	5	HIVEP1	6	12161735	Missense_Mutation	SNP	A	TCGA-CQ-6222-01A-11D-1912-08	4081509	12161735	158953332	25	19655											
HIST1H1C	3006	broad.mit.edu	37	chr6	26056552	26056552	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgacaccgggggaccagaCgccttacgaggcgtaccccc	8	5	12	16	4	1	2	0	1	1	1	1	4	1	3	5	3	2	1	5	3	2	2	rs139532972	byFrequency	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:26056552C>T	uc003nfw.2	-	1	148	c.105G>A	c.(103-105)GCG>GCA	p.A35A		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	35					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GGGGACCAGACGCCTTACGAG	0.632													9	91					0	0	0	0	T	26056552	T	T	26056552	2	4	104	1	0	0	0	0	0	0	0	1	7163	523	19	1		1	HIST1H1C	6	26056552	Silent	SNP	C	TCGA-CQ-6222-01A-11D-1912-08	13894817	26056552	145058515	26	19656											
MDN1	23195	broad.mit.edu	37	chr6	90380712	90380712	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actacggtgagttgctaaagAcatggtcaggaagaagagga	15	7	14	5	1	1	4	1	1	0	3	1	6	1	6	0	4	2	2	0	4	5	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:90380712A>G	uc003pnn.1	-	83	13998	c.13882T>C	c.(13882-13884)TCT>CCT	p.S4628P		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4628					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTTGCTAAAGACATGGTCAGG	0.532													4	81					0	0	0	0	G	90380712	G	G	90380712	3	3	104	1	0	0	0	0	1	0	0	0	9468	275	10	5	2988	5	MDN1	6	90380712	Missense_Mutation	SNP	A	TCGA-CQ-6222-01A-11D-1912-08	64324160	90380712	80734355	27	19657											
PLAGL1	5325	broad.mit.edu	37	chr6	144263171	144263171	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggactgagggtgaggctaTggacctcagctggcaagcta	9	7	17	8	0	1	2	1	2	0	0	1	4	1	4	1	6	2	4	1	6	3	2			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:144263171T>C	uc003qjv.2	-	3	2048	c.782A>G	c.(781-783)CAT>CGT	p.H261R	PLAGL1_uc003qjx.2_Missense_Mutation_p.H261R|PLAGL1_uc003qjy.2_Missense_Mutation_p.H261R|PLAGL1_uc010khl.2_Missense_Mutation_p.H261R|PLAGL1_uc010khm.2_Missense_Mutation_p.H261R|PLAGL1_uc003qjz.2_Missense_Mutation_p.H261R|PLAGL1_uc003qka.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkb.2_Missense_Mutation_p.H209R|PLAGL1_uc003qkc.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkd.2_Missense_Mutation_p.H209R|PLAGL1_uc003qke.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkf.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkg.2_Missense_Mutation_p.H209R|PLAGL1_uc003qkh.2_Missense_Mutation_p.H261R|PLAGL1_uc003qki.2_Missense_Mutation_p.H209R|PLAGL1_uc003qkj.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkk.2_Missense_Mutation_p.H209R|PLAGL1_uc003qkl.2_Missense_Mutation_p.H209R|PLAGL1_uc003qkm.2_Missense_Mutation_p.H261R|PLAGL1_uc010khn.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkn.2_Missense_Mutation_p.H209R|PLAGL1_uc003qko.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkp.2_Missense_Mutation_p.H209R|PLAGL1_uc003qjw.2_Missense_Mutation_p.H209R	NM_002656	NP_002647	Q9UM63	PLAL1_HUMAN	pleiomorphic adenoma gene-like 1 isoform 1	261					cell cycle arrest|induction of apoptosis|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.74e-07)|GBM - Glioblastoma multiforme(68;0.0885)		GGTGAGGCTATGGACCTCAGC	0.612											OREG0017707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	123					0	0	0	0	C	144263171	C	C	144263171	3	2	104	1	0	0	0	0	1	0	0	0	12074	1464	51	5	613	5	PLAGL1	6	144263171	Missense_Mutation	SNP	T	TCGA-CQ-6222-01A-11D-1912-08	53882459	144263171	26851896	28	19658											
VIP	7432	broad.mit.edu	37	chr6	153073384	153073384	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgctcttctcacagacttcGgcatggcctctttacagggc	6	12	10	13	1	3	1	1	0	3	1	5	1	3	1	1	3	2	2	1	3	1	4			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:153073384G>A	uc003qpe.2	+	2	244	c.72G>A	c.(70-72)TCG>TCA	p.S24S	VIP_uc003qpf.2_Silent_p.S24S|VIP_uc010kjd.2_Silent_p.S24S	NM_003381	NP_003372	P01282	VIP_HUMAN	vasoactive intestinal peptide isoform 1	24					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity				0		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		CACAGACTTCGGCATGGCCTC	0.463													8	44					0	0	0	0	A	153073384	A	A	153073384	2	1	104	1	0	0	0	0	0	0	0	1	17235	1103	39	1		1	VIP	6	153073384	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	8810213	153073384	18041683	29	19659											
TIAM2	26230	broad.mit.edu	37	chr6	155565824	155565824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttggaagtttgccagagatGcttgagtttcagaaggtgtt	9	15	13	4	0	1	3	1	1	0	2	1	5	1	4	1	2	2	4	1	2	2	5			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:155565824G>A	uc003qqb.2	+	20	4723	c.3450G>A	c.(3448-3450)ATG>ATA	p.M1150I	TIAM2_uc003qqe.2_Missense_Mutation_p.M1150I|TIAM2_uc010kjj.2_Missense_Mutation_p.M683I|TIAM2_uc003qqf.2_Missense_Mutation_p.M526I|TIAM2_uc011efl.1_Missense_Mutation_p.M486I|TIAM2_uc003qqg.2_Missense_Mutation_p.M462I|TIAM2_uc003qqh.2_Missense_Mutation_p.M75I	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1150	DH.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGCCAGAGATGCTTGAGTTTC	0.438													8	104					0	0	0	0	A	155565824	A	A	155565824	3	1	104	1	0	0	0	0	1	0	0	0	15957	1319	46	4	3508	4	TIAM2	6	155565824	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	2492440	155565824	15549243	30	19660											
MLLT4	4301	broad.mit.edu	37	chr6	168352492	168352492	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccacaggaaacagtcattcgGgagctgcagcctcagcagca	12	5	11	13	1	2	0	2	0	0	0	3	2	2	2	2	2	6	4	2	2	1	1			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:168352492G>A	uc003qwd.2	+	29	4576	c.4434G>A	c.(4432-4434)CGG>CGA	p.R1478R	MLLT4_uc003qwb.1_Silent_p.R1463R|MLLT4_uc003qwc.1_Silent_p.R1479R|MLLT4_uc003qwg.1_Silent_p.R788R	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1479					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CAGTCATTCGGGAGCTGCAGC	0.577			T	MLL	AL								8	81					0	0	0	0	A	168352492	A	A	168352492	2	1	104	1	0	0	0	0	0	0	0	1	9682	1219	43	4		4	MLLT4	6	168352492	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	12786668	168352492	2762575	31	19661											
RAPGEF5	9771	broad.mit.edu	37	chr7	22190088	22190088	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgcctcgagggatttggaGatgactaagtcatttggctg	9	12	14	6	1	1	2	1	1	0	1	2	6	1	3	1	3	1	1	1	3	1	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr7:22190088G>A	uc003svg.2	-	18	1675	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I	RAPGEF5_uc011jyl.1_Silent_p.I135I	NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	304					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						GGGATTTGGAGATGACTAAGT	0.378													4	90					0	0	0	0	A	22190088	A	A	22190088	2	1	104	1	0	0	0	0	0	0	0	1	13112	932	33	2		2	RAPGEF5	7	22190088	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08		22190088	136948575	32	19662											
AEBP1	165	broad.mit.edu	37	chr7	44151908	44151908	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccctgaacgctacctttcGccagatgccacggtgaggct	8	9	10	14	3	0	3	0	2	0	1	2	3	1	3	4	2	3	2	4	2	2	2			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr7:44151908G>A	uc003tkb.2	+	17	2510	c.2205G>A	c.(2203-2205)TCG>TCA	p.S735S	AEBP1_uc003tkc.3_Silent_p.S310S|AEBP1_uc003tkd.2_5'UTR	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	735	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCTACCTTTCGCCAGATGCCA	0.622													5	42					0	0	0	0	A	44151908	A	A	44151908	2	1	104	1	0	0	0	0	0	0	0	1	349	1074	38	1		1	AEBP1	7	44151908	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	21961820	44151908	114986755	33	19663											
PTPN12	5782	broad.mit.edu	37	chr7	77256908	77256908	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttctgctgccactagtactGaaagcatttctactaggaaa	12	13	7	9	0	2	1	0	1	2	0	2	2	2	2	1	1	5	3	1	1	6	6			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr7:77256908G>A	uc003ugh.2	+	13	2003	c.1912G>A	c.(1912-1914)GAA>AAA	p.E638K	PTPN12_uc011kgp.1_Missense_Mutation_p.E519K|PTPN12_uc011kgq.1_Missense_Mutation_p.E508K|PTPN12_uc010lds.2_Missense_Mutation_p.E370K	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	638						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						CACTAGTACTGAAAGCATTTC	0.373													4	47					0	0	0	0	A	77256908	A	A	77256908	3	1	104	1	0	0	0	0	1	0	0	0	12844	1291	45	2	1962	2	PTPN12	7	77256908	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	33105000	77256908	81881755	34	19664											
PPP1R9A	55607	broad.mit.edu	37	chr7	94539551	94539551	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaacccaagtcagatggggaAcaaaaaacaaaagaaggtga	22	3	10	6	0	1	3	1	1	0	2	1	4	1	4	1	3	3	0	1	3	9	0			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr7:94539551A>G	uc003unp.2	+	2	408	c.126A>G	c.(124-126)GAA>GAG	p.E42E	PPP1R9A_uc010lfj.2_Silent_p.E42E|PPP1R9A_uc011kif.1_Silent_p.E42E|PPP1R9A_uc003unq.2_Silent_p.E42E|PPP1R9A_uc011kig.1_Silent_p.E42E	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	42	Actin-binding.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CAGATGGGGAACAAAAAACAA	0.453										HNSCC(28;0.073)			4	32					0	0	0	0	G	94539551	G	G	94539551	2	3	104	1	0	0	0	0	0	0	0	1	12438	40	2	5		5	PPP1R9A	7	94539551	Silent	SNP	A	TCGA-CQ-6222-01A-11D-1912-08	17282643	94539551	64599112	35	19665											
XPO7	23039	broad.mit.edu	37	chr8	21857170	21857170	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctctcttccatttctgaaGgacttactgcacttggtaag	8	16	7	10	0	3	1	0	1	3	0	5	2	4	2	1	2	2	2	1	2	3	6			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr8:21857170G>T	uc003xaa.3	+	24	2869	c.2767G>T	c.(2767-2769)GGA>TGA	p.G923*	XPO7_uc010lti.2_Nonsense_Mutation_p.G932*|XPO7_uc010ltk.2_Nonsense_Mutation_p.G924*	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	923					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		CATTTCTGAAGGACTTACTGC	0.433													5	45					3.59834e-05	0.000193126	1	0	T	21857170	T	T	21857170	4	4	104	1	0	0	0	0	0	1	0	0	17517	1001	35	4	2913	4	XPO7	8	21857170	Nonsense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08		21857170	124506852	36	19666											
YTHDF3	253943	broad.mit.edu	37	chr8	64099642	64099642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaatcgctgggtagctcctcGtaacaggggagcaggcttca	9	8	14	10	2	1	0	1	0	0	0	4	2	2	1	1	4	3	6	1	4	3	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr8:64099642G>A	uc003xuy.2	+	5	1389	c.1073G>A	c.(1072-1074)CGT>CAT	p.R358H	YTHDF3_uc010lys.2_Missense_Mutation_p.R302H|YTHDF3_uc003xuz.2_Missense_Mutation_p.R302H|YTHDF3_uc003xva.2_Missense_Mutation_p.R302H|YTHDF3_uc011len.1_Missense_Mutation_p.R302H	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	358											0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			GTAGCTCCTCGTAACAGGGGA	0.547													7	18					0	0	0	0	A	64099642	A	A	64099642	3	1	104	1	0	0	0	0	1	0	0	0	17568	1145	40	1	1086	1	YTHDF3	8	64099642	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	42242472	64099642	82264380	37	19667											
COL22A1	169044	broad.mit.edu	37	chr8	139635989	139635989	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctttaccggctctccaggggGacccggctttccatctctgc	4	11	10	16	2	2	0	0	0	2	0	5	1	3	1	4	4	2	2	4	4	1	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr8:139635989G>C	uc003yvd.2	-	52	4204	c.3757C>G	c.(3757-3759)CCC>GCC	p.P1253A	COL22A1_uc011ljo.1_Missense_Mutation_p.P533A	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1253	Pro-rich.|Gly-rich.|Collagen-like 12.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCTCCAGGGGGACCCGGCTTT	0.388										HNSCC(7;0.00092)			53	171					0	0	0	0	C	139635989	C	C	139635989	3	2	104	1	0	0	0	0	1	0	0	0	3696	1174	41	2	1179	2	COL22A1	8	139635989	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	75536347	139635989	6728033	38	19668											
KDM4C	23081	broad.mit.edu	37	chr9	6893144	6893144	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactttcccatatggctaccAtgctggttttaatcatggtt	8	16	7	10	0	1	0	1	0	0	0	2	0	2	0	2	3	2	4	2	3	3	6			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr9:6893144A>T	uc003zkh.2	+	8	1413	c.833A>T	c.(832-834)CAT>CTT	p.H278L	KDM4C_uc010mhu.2_Missense_Mutation_p.H300L|KDM4C_uc010mhw.2_Missense_Mutation_p.H278L|KDM4C_uc011lmi.1_Missense_Mutation_p.H278L|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.H278L|KDM4C_uc011lmk.1_Missense_Mutation_p.H97L	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	278	JmjC.	Iron; catalytic (By similarity).			positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						TATGGCTACCATGCTGGTTTT	0.368													7	80					0	0	0	0	T	6893144	T	T	6893144	3	4	104	1	0	0	0	0	1	0	0	0	8169	217	8	5	929	5	KDM4C	9	6893144	Missense_Mutation	SNP	A	TCGA-CQ-6222-01A-11D-1912-08		6893144	134320287	39	19669											
RUSC2	9853	broad.mit.edu	37	chr9	35555624	35555624	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgcctctgggctcctggcGatctggcctcagccgagcag	4	7	14	16	3	3	0	1	0	2	0	4	2	4	0	5	3	2	2	5	3	0	0			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr9:35555624G>A	uc003zww.2	+	3	2837	c.2582G>A	c.(2581-2583)CGA>CAA	p.R861Q	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.R861Q	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	861						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GGCTCCTGGCGATCTGGCCTC	0.637													6	50					0	0	0	0	A	35555624	A	A	35555624	3	1	104	1	0	0	0	0	1	0	0	0	13816	1058	37	1	2588	1	RUSC2	9	35555624	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	28662480	35555624	105657807	40	19670											
FLJ46321	389763	broad.mit.edu	37	chr9	84606763	84606763	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atatgttaacctcaattgctGttaagcatgacttggcagaa	13	13	8	7	0	1	2	1	1	0	1	1	2	1	2	1	1	3	5	1	1	5	5			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr9:84606763G>T	uc004amn.2	+	4	1425	c.1378G>T	c.(1378-1380)GTT>TTT	p.V460F		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	460						integral to membrane					0						CTCAATTGCTGTTAAGCATGA	0.418													11	73					3.86212e-05	0.000204692	1	0	T	84606763	T	T	84606763	3	4	104	1	0	0	0	0	1	0	0	0	5964	1377	48	4	1392	4	FLJ46321	9	84606763	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	49051139	84606763	56606668	41	19671											
IARS	3376	broad.mit.edu	37	chr9	95004546	95004546	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggctttcaataacactatTcagatatgttccttcagact	11	15	6	9	0	3	2	3	0	0	2	4	2	4	2	1	1	1	2	1	1	4	7			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr9:95004546T>A	uc004art.1	-	29	3324	c.3067A>T	c.(3067-3069)AAT>TAT	p.N1023Y	IARS_uc004ars.1_Missense_Mutation_p.N868Y|IARS_uc004aru.3_Missense_Mutation_p.N1023Y|IARS_uc010mqr.2_Missense_Mutation_p.N913Y|IARS_uc010mqt.2_Missense_Mutation_p.N246Y	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	1023					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	ATAACACTATTCAGATATGTT	0.368													7	33					0	0	0	0	A	95004546	A	A	95004546	3	1	104	1	0	0	0	0	1	0	0	0	7512	1783	62	5	745	5	IARS	9	95004546	Missense_Mutation	SNP	T	TCGA-CQ-6222-01A-11D-1912-08	10397783	95004546	46208885	42	19672											
MUSK	4593	broad.mit.edu	37	chr9	113563104	113563104	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggaggtcatttactacgtgCgagatggcaacatcctctcc	10	10	10	11	2	2	1	1	0	1	1	4	3	3	2	2	3	4	1	2	3	3	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr9:113563104C>T	uc004bey.2	+	14	2544	c.2446C>T	c.(2446-2448)CGA>TGA	p.R816*	MUSK_uc004bez.1_Nonsense_Mutation_p.R396*	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	816	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						TTACTACGTGCGAGATGGCAA	0.557													4	34					0	0	0	0	T	113563104	T	T	113563104	4	4	104	1	0	0	0	0	0	1	0	0	10042	760	27	1	2536	1	MUSK	9	113563104	Nonsense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08	18558558	113563104	27650327	43	19673											
PIP4K2A	5305	broad.mit.edu	37	chr10	22898587	22898587	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccacctttatttttgaataGgctttgaagtcatctggcat	9	17	7	8	0	2	2	1	2	1	0	3	2	3	2	2	2	0	2	2	2	4	6			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:22898587G>A	uc001irl.3	-	2	452	c.204C>T	c.(202-204)GCC>GCT	p.A68A		NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	68	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						TTTTTGAATAGGCTTTGAAGT	0.353													7	53					0	0	0	0	A	22898587	A	A	22898587	2	1	104	1	0	0	0	0	0	0	0	1	11991	987	35	4		4	PIP4K2A	10	22898587	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08		22898587	112636160	44	19674											
KIAA1462	57608	broad.mit.edu	37	chr10	30315782	30315782	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctccggatgcccggcaggaGggactccaccgccacctcaa	8	5	11	17	3	2	0	1	0	1	0	4	3	3	3	6	4	1	1	6	4	1	0			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:30315782G>A	uc001iux.2	-	2	3354	c.3295C>T	c.(3295-3297)CTC>TTC	p.L1099F	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.L961F|KIAA1462_uc009xle.1_Missense_Mutation_p.L1099F	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1099										ovary(4)	4						CCCGGCAGGAGGGACTCCACC	0.627													9	105					0	0	0	0	A	30315782	A	A	30315782	3	1	104	1	0	0	0	0	1	0	0	0	8273	1000	35	4	792	4	KIAA1462	10	30315782	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	7417195	30315782	105218965	45	19675											
ANK3	288	broad.mit.edu	37	chr10	62023666	62023666	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtgtcgtcttttcgggccGcgatatgaagagctgggaga	7	11	15	8	5	1	3	0	1	1	2	4	5	1	3	1	2	1	1	1	2	2	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:62023666G>A	uc001jky.2	-	6	818	c.626C>T	c.(625-627)GCG>GTG	p.A209V	ANK3_uc010qih.1_Missense_Mutation_p.A192V|ANK3_uc001jkz.3_Missense_Mutation_p.A203V|ANK3_uc001jlb.1_5'UTR	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	209	ANK 5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTTTCGGGCCGCGATATGAAG	0.552													12	51					0	0	0	0	A	62023666	A	A	62023666	3	1	104	1	0	0	0	0	1	0	0	0	622	1087	38	1	12992	1	ANK3	10	62023666	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	31707884	62023666	73511081	46	19676											
C10orf54	64115	broad.mit.edu	37	chr10	73521632	73521632	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgagcaggtctgcacctcGcccctcgagctgcggtacca	6	8	11	16	3	2	1	0	1	2	0	4	2	2	1	4	2	5	4	4	2	1	1			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:73521632G>T	uc001jsd.2	-	2	375	c.234C>A	c.(232-234)GGC>GGA	p.G78G	CDH23_uc001jrx.3_Intron|C10orf54_uc001jse.2_5'UTR|C10orf54_uc009xqm.2_Intron|C10orf54_uc001jsf.1_Silent_p.G78G	NM_022153	NP_071436	Q9H7M9	GI24_HUMAN	platelet receptor Gi24 precursor	78	Ig-like.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TCTGCACCTCGCCCCTCGAGC	0.647													5	47					0.000602214	0.00315233	1	0	T	73521632	T	T	73521632	2	4	104	1	0	0	0	0	0	0	0	1	1613	1074	38	3		3	C10orf54	10	73521632	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	11497966	73521632	62013115	47	19677											
PSD	5662	broad.mit.edu	37	chr10	104164346	104164346	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagcttgggctacctgggaGaggcgggtggcagcgctggg	6	6	21	8	2	0	2	0	0	0	2	0	3	0	2	1	6	3	4	1	6	1	2			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:104164346G>C	uc001kvg.1	-	15	3221	c.2694C>G	c.(2692-2694)CTC>CTG	p.L898L	PSD_uc001kve.1_Silent_p.L106L|PSD_uc001kvf.1_Silent_p.L267L|PSD_uc001kvh.1_Silent_p.L519L|PSD_uc009xxd.1_Silent_p.L898L	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	898	Potential.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CTACCTGGGAGAGGCGGGTGG	0.532													3	66					0	0	0	0	C	104164346	C	C	104164346	2	2	104	1	0	0	0	0	0	0	0	1	12708	929	33	2		2	PSD	10	104164346	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	30642714	104164346	31370401	48	19678											
ZNF143	7702	broad.mit.edu	37	chr11	9500065	9500065	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggctgatgggacagtggcaGgtctgcacactggggatgct	8	8	17	8	0	1	1	0	1	1	0	1	3	1	3	0	6	2	4	0	6	0	0			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr11:9500065G>A	uc001mhr.2	+	6	620	c.502G>A	c.(502-504)GGT>AGT	p.G168S	ZNF143_uc009yfu.2_Missense_Mutation_p.G167S|ZNF143_uc010rby.1_Missense_Mutation_p.G137S	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	168					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		GACAGTGGCAGGTCTGCACAC	0.493													8	90					0	0	0	0	A	9500065	A	A	9500065	3	1	104	1	0	0	0	0	1	0	0	0	17799	1000	35	4	520	4	ZNF143	11	9500065	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08		9500065	125506451	49	19679											
LRP4	4038	broad.mit.edu	37	chr11	46898166	46898166	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggccaatggcatcaaccgcGagcccatctgtggtctgtag	8	8	12	13	3	3	0	1	0	2	0	3	1	3	0	3	3	2	2	3	3	3	1			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr11:46898166G>A	uc001ndn.3	-	25	3533	c.3387C>T	c.(3385-3387)CTC>CTT	p.L1129L		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1129	Extracellular (Potential).|LDL-receptor class B 11.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CATCAACCGCGAGCCCATCTG	0.537													11	85					0	0	0	0	A	46898166	A	A	46898166	2	1	104	1	0	0	0	0	0	0	0	1	9009	1045	37	1		1	LRP4	11	46898166	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	37398101	46898166	88108350	50	19680											
ADAMTS8	11095	broad.mit.edu	37	chr11	130278733	130278733	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acttgcagcggtcccgggggGacaccccagcatacttgggg	7	6	15	13	2	0	0	0	0	0	0	1	1	1	1	3	6	4	2	3	6	1	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr11:130278733G>T	uc001qgg.3	-	7	2211	c.1853C>A	c.(1852-1854)TCC>TAC	p.S618Y	ADAMTS8_uc001qgf.2_Missense_Mutation_p.S99Y	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	618	Cys-rich.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GTCCCGGGGGGACACCCCAGC	0.562													14	111					2.32078e-09	1.32975e-08	1	0	T	130278733	T	T	130278733	3	4	104	1	0	0	0	0	1	0	0	0	272	1174	41	2	828	2	ADAMTS8	11	130278733	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	83380567	130278733	4727783	51	19681											
TULP3	7289	broad.mit.edu	37	chr12	3048518	3048518	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggacgtgtggcagatgacGtgttcacactggattacaac	10	11	12	8	2	1	2	1	1	0	1	1	4	1	4	0	3	2	2	0	3	2	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr12:3048518G>A	uc010seh.1	+	11	1318	c.1237G>A	c.(1237-1239)GTG>ATG	p.V413M	TULP3_uc009zec.1_Missense_Mutation_p.V140M|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Missense_Mutation_p.V413M|TULP3_uc010sei.1_Missense_Mutation_p.V237M	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	413					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GGCAGATGACGTGTTCACACT	0.428													11	112					0	0	0	0	A	3048518	A	A	3048518	3	1	104	1	0	0	0	0	1	0	0	0	16843	1145	40	1	1279	1	TULP3	12	3048518	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08		3048518	130803377	52	19682											
SPRYD3	84926	broad.mit.edu	37	chr12	53471030	53471030	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggttgaggtcatccatcttGttcatgagaacaaacctgcc	11	11	9	10	0	3	2	2	2	1	1	4	3	4	2	3	2	3	2	3	2	2	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr12:53471030G>T	uc001sbt.1	-	2	60	c.39C>A	c.(37-39)AAC>AAA	p.N13K	SPRYD3_uc010snw.1_5'UTR	NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	13										central_nervous_system(1)	1						CATCCATCTTGTTCATGAGAA	0.547													7	26					1.06961e-07	5.88982e-07	1	0	T	53471030	T	T	53471030	3	4	104	1	0	0	0	0	1	0	0	0	15175	1368	48	4	1329	4	SPRYD3	12	53471030	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	50422512	53471030	80380865	53	19683											
SSH1	54434	broad.mit.edu	37	chr12	109194621	109194621	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtctgtggtctcttcatcGtagactcggatgttatgata	8	15	11	7	2	3	2	1	1	2	1	6	3	3	3	0	3	0	2	0	3	3	4			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr12:109194621G>A	uc001tnm.2	-	12	1170	c.1083C>T	c.(1081-1083)TAC>TAT	p.Y361Y	SSH1_uc001tnl.2_Silent_p.Y49Y|SSH1_uc010sxg.1_Silent_p.Y372Y|SSH1_uc001tnn.3_Silent_p.Y361Y	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	361	Tyrosine-protein phosphatase.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						TCTCTTCATCGTAGACTCGGA	0.398													14	114					0	0	0	0	A	109194621	A	A	109194621	2	1	104	1	0	0	0	0	0	0	0	1	15250	1140	40	1		1	SSH1	12	109194621	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	55723591	109194621	24657274	54	19684											
ACACB	32	broad.mit.edu	37	chr12	109617746	109617746	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatccgcctggccaagaccGtgggctatgtgagtgcaggg	7	7	15	12	2	0	2	0	1	0	1	1	2	1	2	5	3	1	2	5	3	2	1			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr12:109617746G>A	uc001tob.2	+	11	1791	c.1672G>A	c.(1672-1674)GTG>ATG	p.V558M	ACACB_uc001toc.2_Missense_Mutation_p.V558M	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	558	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGCCAAGACCGTGGGCTATGT	0.527													6	53					0	0	0	0	A	109617746	A	A	109617746	3	1	104	1	0	0	0	0	1	0	0	0	107	1145	40	1	1710	1	ACACB	12	109617746	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	423125	109617746	24234149	55	19685											
ATP12A	479	broad.mit.edu	37	chr13	25265211	25265211	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagttggaaatgagaagacGcccattgccattgagatcga	13	8	13	7	2	0	3	0	2	0	3	1	8	0	5	2	2	1	1	2	2	2	3	rs61739266	byFrequency	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr13:25265211G>A	uc001upp.2	+	8	1078	c.891G>A	c.(889-891)ACG>ACA	p.T297T	ATP12A_uc010aaa.2_Silent_p.T303T	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	297	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ATGAGAAGACGCCCATTGCCA	0.522													9	69					0	0	0	0	A	25265211	A	A	25265211	2	1	104	1	0	0	0	0	0	0	0	1	1124	1074	38	1		1	ATP12A	13	25265211	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08		25265211	89904667	56	19686											
SLITRK5	26050	broad.mit.edu	37	chr13	88328670	88328670	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacccaacaagcccagggtgCgccccacctctcggcagccc	9	3	9	20	2	1	0	0	0	1	0	2	0	1	0	6	2	5	1	6	2	3	0			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr13:88328670C>T	uc001vln.2	+	2	1246	c.1027C>T	c.(1027-1029)CGC>TGC	p.R343C	SLITRK5_uc010tic.1_Missense_Mutation_p.R102C	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	343	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCCCAGGGTGCGCCCCACCTC	0.597													8	93					0	0	0	0	T	88328670	T	T	88328670	3	4	104	1	0	0	0	0	1	0	0	0	14810	768	27	1	1029	1	SLITRK5	13	88328670	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08	63063459	88328670	26841208	57	19687											
EML5	161436	broad.mit.edu	37	chr14	89206756	89206756	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggctccttgtattgttcgtAtaagattgattcctttccaa	8	17	8	8	1	0	2	0	1	0	1	4	2	3	2	3	1	0	4	3	1	4	9			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr14:89206756A>G	uc001xxg.2	-	6	872	c.686T>C	c.(685-687)ATA>ACA	p.I229T		NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	229	WD 4.					cytoplasm|microtubule				ovary(3)	3						TATTGTTCGTATAAGATTGAT	0.363													5	47					0	0	0	0	G	89206756	G	G	89206756	3	3	104	1	0	0	0	0	1	0	0	0	5124	449	16	5	5403	5	EML5	14	89206756	Missense_Mutation	SNP	A	TCGA-CQ-6222-01A-11D-1912-08		89206756	18142784	58	19688											
PKD1	5310	broad.mit.edu	37	chr16	2153543	2153543	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagacggtgtagttgctgaTatagccaaagggaaagggat	13	8	16	4	1	0	2	0	1	0	1	0	5	0	4	1	4	2	3	1	4	5	4			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr16:2153543T>C	uc002cos.1	-	23	8724	c.8515A>G	c.(8515-8517)ATC>GTC	p.I2839V	PKD1_uc002cot.1_Missense_Mutation_p.I2839V|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2839	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TAGTTGCTGATATAGCCAAAG	0.612													7	86					0	0	0	0	C	2153543	C	C	2153543	3	2	104	1	0	0	0	0	1	0	0	0	12018	1406	49	5	4492	5	PKD1	16	2153543	Missense_Mutation	SNP	T	TCGA-CQ-6222-01A-11D-1912-08		2153543	88201210	59	19689											
ABCC1	4363	broad.mit.edu	37	chr16	16205306	16205306	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctcagcatcttccttttCatgtgtaaccatgtgtccgc	6	16	6	13	1	3	0	2	0	1	0	6	0	6	0	4	0	2	2	4	0	1	5			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr16:16205306C>T	uc010bvi.2	+	22	3121	c.2946C>T	c.(2944-2946)TTC>TTT	p.F982F	ABCC1_uc010bvj.2_Silent_p.F923F|ABCC1_uc010bvk.2_Silent_p.F926F|ABCC1_uc010bvl.2_Silent_p.F982F|ABCC1_uc010bvm.2_Silent_p.F867F|ABCC1_uc002del.3_Silent_p.F876F	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	982	Helical; Name=12.|ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCTTCCTTTTCATGTGTAACC	0.537													13	135					0	0	0	0	T	16205306	T	T	16205306	2	4	104	1	0	0	0	0	0	0	0	1	49	825	29	2		2	ABCC1	16	16205306	Silent	SNP	C	TCGA-CQ-6222-01A-11D-1912-08	14051763	16205306	74149447	60	19690											
CHST6	4166	broad.mit.edu	37	chr16	75512895	75512895	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttctgccagcggctcccGcgccaggtcctcgaagcgca	6	7	12	16	5	1	0	0	0	1	0	4	2	3	0	4	2	3	2	4	2	1	1			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr16:75512895G>A	uc002fef.2	-	3	1012	c.832C>T	c.(832-834)CGG>TGG	p.R278W	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.R278W	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	278	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGCGGCTCCCGCGCCAGGTCC	0.667													6	51					0	0	0	0	A	75512895	A	A	75512895	3	1	104	1	0	0	0	0	1	0	0	0	3423	1086	38	1	359	1	CHST6	16	75512895	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	59307589	75512895	14841858	61	19691											
JPH3	57338	broad.mit.edu	37	chr16	87678468	87678468	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacggctgcatgaccttcccGgacggcaccaaggaggaggg	9	5	15	12	3	0	1	0	1	0	0	1	4	1	4	3	6	2	3	3	6	2	2	rs150628659		TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr16:87678468G>A	uc002fkd.2	+	2	1241	c.987G>A	c.(985-987)CCG>CCA	p.P329P	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	329	Cytoplasmic (Potential).|MORN 8.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		TGACCTTCCCGGACGGCACCA	0.662													5	60					0	0	0	0	A	87678468	A	A	87678468	2	1	104	1	0	0	0	0	0	0	0	1	8001	1103	39	1		1	JPH3	16	87678468	Silent	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	12165573	87678468	2676285	62	19692											
P2RX1	5023	broad.mit.edu	37	chr17	3819509	3819509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggccagctcctcctggaacCgccgtgccatggtgggccgg	4	6	15	16	4	0	0	0	0	0	0	2	1	2	1	7	5	3	1	7	5	1	0			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr17:3819509C>T	uc002fww.2	-	1	452	c.11G>A	c.(10-12)CGG>CAG	p.R4Q	P2RX1_uc010ckm.1_5'UTR	NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	4	Cytoplasmic (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		CTCCTGGAACCGCCGTGCCAT	0.642													17	108					0	0	0	0	T	3819509	T	T	3819509	3	4	104	1	0	0	0	0	1	0	0	0	11393	652	23	1	1236	1	P2RX1	17	3819509	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08		3819509	77375701	63	19693											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	5	11	9	16	2	3	0	0	0	3	0	7	1	5	1	3	3	1	1	3	3	0	2	rs28934574		TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	30					0	0	0	0	A	7577094	A	A	7577094	3	1	104	1	0	0	0	0	1	0	0	0	16448	1115	39	1	442	1	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	3757585	7577094	73618116	64	19694											
TP53	7157	broad.mit.edu	37	chr17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcaccaccacactatgtcGaaaagtgtttctgtcatcca	11	10	8	12	1	2	0	1	0	1	0	4	1	3	0	3	1	0	2	3	1	3	2			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	28					0	0	0	0	A	7578212	A	A	7578212	4	1	104	1	0	0	0	0	0	1	0	0	16448	1066	37	1	657	1	TP53	17	7578212	Nonsense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	1118	7578212	73616998	65	19695											
COASY	80347	broad.mit.edu	37	chr17	40714773	40714773	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttcacctgcagccgggcAtgagcctggagggcccggct	6	7	15	13	2	1	1	1	1	0	0	1	2	1	2	4	4	3	4	4	4	0	1			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr17:40714773A>G	uc002hzz.2	+	2	290	c.133A>G	c.(133-135)ATG>GTG	p.M45V	COASY_uc010cyj.2_Missense_Mutation_p.M74V|COASY_uc002iab.2_Intron|COASY_uc002iad.2_Missense_Mutation_p.M45V|COASY_uc002iac.2_Missense_Mutation_p.M45V|COASY_uc002iae.2_5'Flank	NM_001042529	NP_001035994	Q13057	COASY_HUMAN	coenzyme A synthase isoform a	45					coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity				0		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		GCAGCCGGGCATGAGCCTGGA	0.662													5	86					0	0	0	0	G	40714773	G	G	40714773	3	3	104	1	0	0	0	0	1	0	0	0	3667	217	8	5	226	5	COASY	17	40714773	Missense_Mutation	SNP	A	TCGA-CQ-6222-01A-11D-1912-08	33136561	40714773	40480437	66	19696											
AXIN2	8313	broad.mit.edu	37	chr17	63537655	63537655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtttcttactgcccacaCgataaggaggaattccatct	10	12	8	11	1	2	0	0	0	2	0	3	3	3	2	2	2	2	2	2	2	3	4			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr17:63537655C>T	uc002jfi.2	-	4	1266	c.977G>A	c.(976-978)CGT>CAT	p.R326H	AXIN2_uc010den.1_Missense_Mutation_p.R326H|AXIN2_uc002jfh.2_Missense_Mutation_p.R326H	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	326					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						ACTGCCCACACGATAAGGAGG	0.478									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				11	85					0	0	0	0	T	63537655	T	T	63537655	3	4	104	1	0	0	0	0	1	0	0	0	1239	536	19	1	1586	1	AXIN2	17	63537655	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08	22822882	63537655	17657555	67	19697											
SMAD4	4089	broad.mit.edu	37	chr18	48581208	48581208	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgactttgagggacagccatCgttgtccactgaaggacatt	10	11	11	9	1	0	3	0	3	0	0	2	5	1	5	2	2	1	1	2	2	1	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr18:48581208C>T	uc010xdp.1	+	5	1050	c.512C>T	c.(511-513)TCG>TTG	p.S171L	SMAD4_uc010xdo.1_RNA|SMAD4_uc002lfb.3_Missense_Mutation_p.S16L	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	171					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(3)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GGACAGCCATCGTTGTCCACT	0.398									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				5	51					0	0	0	0	T	48581208	T	T	48581208	3	4	104	1	0	0	0	0	1	0	0	0	14824	893	31	1	526	1	SMAD4	18	48581208	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08		48581208	29496040	68	19698											
SMAD4	4089	broad.mit.edu	37	chr18	48581281	48581281	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtgcatcgacagagacataCagcaccccagctctgttagc	11	7	9	14	2	1	1	0	0	1	1	2	3	1	1	2	0	5	4	2	0	2	2			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr18:48581281C>G	uc010xdp.1	+	5	1123	c.585C>G	c.(583-585)TAC>TAG	p.Y195*	SMAD4_uc010xdo.1_RNA|SMAD4_uc002lfb.3_Nonsense_Mutation_p.Y40*	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	195					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(3)|p.Y195fs*1(1)|p.Y195*(1)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CAGAGACATACAGCACCCCAG	0.483									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				10	88					0	0	0	0	G	48581281	G	G	48581281	4	3	104	1	0	0	0	0	0	1	0	0	14824	489	17	4	599	4	SMAD4	18	48581281	Nonsense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08	73	48581281	29495967	69	19699											
RPS28	6234	broad.mit.edu	37	chr19	8386936	8386936	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcacccttttggagtcagagCgagaagcccggaggttgcgc	8	8	14	11	3	2	2	2	0	0	2	2	5	2	4	2	3	3	1	2	3	1	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr19:8386936C>G	uc002mjn.2	+	3	218	c.187C>G	c.(187-189)CGA>GGA	p.R63G	NDUFA7_uc002mjm.1_5'Flank	NM_001031	NP_001022	P62857	RS28_HUMAN	ribosomal protein S28	63					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome				0						GGAGTCAGAGCGAGAAGCCCG	0.592													3	17					0	0	0	0	G	8386936	G	G	8386936	3	3	104	1	0	0	0	0	1	0	0	0	13706	760	27	3	197	3	RPS28	19	8386936	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08		8386936	50742047	70	19700											
CYP4F8	11283	broad.mit.edu	37	chr19	15739591	15739591	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctatgaccccttccgcttCgacccagaaaacgcccagaa	11	7	7	16	3	1	3	0	1	1	2	3	4	2	3	5	0	1	1	5	0	4	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr19:15739591C>A	uc002nbi.2	+	14	1399	c.1335C>A	c.(1333-1335)TTC>TTA	p.F445L	CYP4F8_uc010xoj.1_Missense_Mutation_p.F257L	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	445					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						CCTTCCGCTTCGACCCAGAAA	0.602													10	59					4.84862e-15	2.81618e-14	1	0	A	15739591	A	A	15739591	3	1	104	1	0	0	0	0	1	0	0	0	4208	883	31	3	1376	3	CYP4F8	19	15739591	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08	7352655	15739591	43389392	71	19701											
ZNF30	90075	broad.mit.edu	37	chr19	35435248	35435248	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaaaccctatgagtgtaagGaatgtggcaaggccttcaga	14	8	12	7	0	1	3	1	1	0	2	1	4	1	4	2	3	1	2	2	3	5	3			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr19:35435248G>T	uc010edp.1	+	5	1756	c.1378G>T	c.(1378-1380)GAA>TAA	p.E460*	ZNF30_uc002nxf.2_Nonsense_Mutation_p.E379*|ZNF30_uc010edq.1_Nonsense_Mutation_p.E461*|ZNF30_uc010edr.1_Nonsense_Mutation_p.E461*	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	460	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		TGAGTGTAAGGAATGTGGCAA	0.428													7	41					2.7689e-08	1.54475e-07	1	0	T	35435248	T	T	35435248	4	4	104	1	0	0	0	0	0	1	0	0	17897	1175	41	2	1395	2	ZNF30	19	35435248	Nonsense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	19695657	35435248	23693735	72	19702											
PIH1D1	55011	broad.mit.edu	37	chr19	49949860	49949860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgagagttgatctgcagcGggatataagcgtctagatga	12	10	13	6	2	2	4	0	3	2	2	2	6	2	5	0	1	3	2	0	1	3	4			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr19:49949860G>A	uc002pns.2	-	8	1063	c.779C>T	c.(778-780)CCG>CTG	p.P260L	uc002pnr.1_5'Flank	NM_017916	NP_060386	Q9NWS0	PIHD1_HUMAN	NOP17	260					box C/D snoRNP assembly	pre-snoRNP complex					0		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		GATCTGCAGCGGGATATAAGC	0.632													10	101					0	0	0	0	A	49949860	A	A	49949860	3	1	104	1	0	0	0	0	1	0	0	0	11961	1116	39	1	101	1	PIH1D1	19	49949860	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	14514612	49949860	9179123	73	19703											
NRIP1	8204	broad.mit.edu	37	chr21	16339480	16339480	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacccattggattttgaaacActgtagcactacttttgcta	11	15	6	9	0	0	1	0	1	0	0	0	2	0	2	1	1	5	3	1	1	5	9			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr21:16339480A>G	uc002yjx.2	-	4	1632	c.1034T>C	c.(1033-1035)GTG>GCG	p.V345A		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	345					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		ATTTTGAAACACTGTAGCACT	0.393													12	73					0	0	0	0	G	16339480	G	G	16339480	3	3	104	1	0	0	0	0	1	0	0	0	10706	159	6	5	2446	5	NRIP1	21	16339480	Missense_Mutation	SNP	A	TCGA-CQ-6222-01A-11D-1912-08		16339480	31790415	74	19704											
INPP5J	27124	broad.mit.edu	37	chr22	31522415	31522415	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgcccccagacgatgtcaCatccctcctccacctgggcg	7	7	8	19	2	1	1	1	0	0	1	4	2	4	1	6	1	1	0	6	1	0	0			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr22:31522415C>T	uc003aju.3	+	3	1417	c.1325C>T	c.(1324-1326)ACA>ATA	p.T442I	INPP5J_uc010gwf.2_Missense_Mutation_p.T442I|INPP5J_uc003ajv.3_Missense_Mutation_p.T75I|INPP5J_uc003ajs.3_Missense_Mutation_p.T75I|INPP5J_uc011alk.1_Missense_Mutation_p.T375I|INPP5J_uc010gwg.2_Missense_Mutation_p.T7I|INPP5J_uc003ajw.2_5'UTR|INPP5J_uc003ajt.3_Missense_Mutation_p.T74I|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	442	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						GACGATGTCACATCCCTCCTC	0.637													10	141					0	0	0	0	T	31522415	T	T	31522415	3	4	104	1	0	0	0	0	1	0	0	0	7798	478	17	4	231	4	INPP5J	22	31522415	Missense_Mutation	SNP	C	TCGA-CQ-6222-01A-11D-1912-08		31522415	19782151	75	19705											
SFI1	9814	broad.mit.edu	37	chr22	32007798	32007798	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctggcacagagactcagccGgacctgcttccgccagtgga	8	6	13	14	2	1	1	1	0	0	1	2	4	2	3	4	3	2	3	4	3	0	1			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr22:32007798G>A	uc003ale.2	+	24	2855	c.2462G>A	c.(2461-2463)CGG>CAG	p.R821Q	SFI1_uc003alf.2_Missense_Mutation_p.R790Q|SFI1_uc003alg.2_Missense_Mutation_p.R739Q|SFI1_uc011alp.1_Missense_Mutation_p.R727Q|SFI1_uc011alq.1_Missense_Mutation_p.R766Q|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA|SFI1_uc003ali.2_5'Flank|SFI1_uc003alj.2_5'Flank	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	821					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						AGACTCAGCCGGACCTGCTTC	0.617													5	39					0	0	0	0	A	32007798	A	A	32007798	3	1	104	1	0	0	0	0	1	0	0	0	14221	1116	39	1	2552	1	SFI1	22	32007798	Missense_Mutation	SNP	G	TCGA-CQ-6222-01A-11D-1912-08	485383	32007798	19296768	76	19706											
OPN1LW	5956	broad.mit.edu	37	chrX	153421950	153421950	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatggctgccctgccggcctActttgccaaaagtgccacta	8	9	10	14	1	0	0	0	0	0	0	0	1	0	0	5	2	5	1	5	2	4	3	rs145631912	byFrequency	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chrX:153421950A>T	uc004fjz.3	+	5	959	c.926A>T	c.(925-927)TAC>TTC	p.Y309F		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	309	Helical; Name=7; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGCCGGCCTACTTTGCCAAA	0.537													45	416					0	0	0	0	T	153421950	T	T	153421950	3	4	104	1	0	0	0	0	1	0	0	0	10931	391	14	5	944	5	OPN1LW	23	153421950	Missense_Mutation	SNP	A	TCGA-CQ-6222-01A-11D-1912-08		153421950	1848610	77	19707											
HSPG2	3339	broad.mit.edu	37	chr1	22199894	22199894	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atggctggccctggctggggTtgccatagtagccaggggcg	5	8	18	10	1	0	0	0	0	0	0	0	0	0	0	3	7	2	4	3	7	2	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:22199894T>C	uc001bfj.2	-	30	3807	c.3767A>G	c.(3766-3768)AAC>AGC	p.N1256S	HSPG2_uc009vqd.2_Missense_Mutation_p.N1257S	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	1256	Laminin EGF-like 7.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CTGGCTGGGGTTGCCATAGTA	0.587													17	95					0	0	0	0	C	22199894	C	C	22199894	3	2	105	1	0	0	0	0	1	0	0	0	7469	1725	60	5	9680	5	HSPG2	1	22199894	Missense_Mutation	SNP	T	TCGA-CQ-6223-01A-11D-1912-08		22199894	227050727	1	19708											
COL16A1	1307	broad.mit.edu	37	chr1	32154663	32154663	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctcaccttctctcctttGatgccttggatgccagggtc	4	14	8	15	0	2	1	1	1	1	0	6	2	4	2	5	2	2	0	5	2	0	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:32154663G>T	uc001btk.1	-	24	2009	c.1644C>A	c.(1642-1644)ATC>ATA	p.I548I	COL16A1_uc001btj.1_Silent_p.I377I|COL16A1_uc001btl.3_Silent_p.I548I	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	548	Triple-helical region 8 (COL8) with 1 imperfection.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TCTCTCCTTTGATGCCTTGGA	0.592													34	72					3.6622e-26	1.67253e-25	1	0	T	32154663	T	T	32154663	2	4	105	1	0	0	0	0	0	0	0	1	3688	1280	45	2		2	COL16A1	1	32154663	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	9954769	32154663	217095958	2	19709											
INADL	10207	broad.mit.edu	37	chr1	62293185	62293185	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttactttggtttgctgtcGgaggttgtttgatgatgaag	6	19	13	3	1	0	3	0	3	0	0	1	4	0	4	0	3	2	4	0	3	2	6			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:62293185G>A	uc001dab.2	+	16	2024	c.1910G>A	c.(1909-1911)CGG>CAG	p.R637Q	INADL_uc009waf.1_Missense_Mutation_p.R637Q|INADL_uc001daa.2_Missense_Mutation_p.R637Q|INADL_uc001dad.3_Missense_Mutation_p.R334Q|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	637	PDZ 4.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						GTTTGCTGTCGGAGGTTGTTT	0.443													40	129					0	0	0	0	A	62293185	A	A	62293185	3	1	105	1	0	0	0	0	1	0	0	0	7770	1116	39	1	1968	1	INADL	1	62293185	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	30138522	62293185	186957436	3	19710											
L1TD1	54596	broad.mit.edu	37	chr1	62672650	62672650	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acaaaaaacagggatggtagGgaaaatagaaggagaaaact	22	4	12	3	0	0	2	0	0	0	2	0	5	0	4	0	4	2	1	0	4	10	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:62672650G>A	uc001dae.3	+	3	652	c.350G>A	c.(349-351)GGG>GAG	p.G117E		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	117										ovary(1)|skin(1)	2						gggatggtagggaaaatagaa	0.05													17	78					0	0	0	0	A	62672650	A	A	62672650	3	1	105	1	0	0	0	0	1	0	0	0	8629	1232	43	4	352	4	L1TD1	1	62672650	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	379465	62672650	186577971	4	19711											
ALG6	29929	broad.mit.edu	37	chr1	63879798	63879798	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaggatattttgccacgtCacatccaattaataatgagg	14	13	7	7	1	1	1	1	1	0	0	2	2	2	2	2	2	1	0	2	2	5	6			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:63879798C>A	uc010oow.1	+	10	1188	c.883C>A	c.(883-885)CAC>AAC	p.H295N	ALG6_uc001daz.2_RNA|ALG6_uc009waj.2_Intron|ALG6_uc010oox.1_Missense_Mutation_p.H94N	NM_013339	NP_037471	Q9Y672	ALG6_HUMAN	dolichyl pyrophosphate Man9GlcNAc2	295					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity				0						TTTGCCACGTCACATCCAATT	0.269													18	41					6.94344e-10	2.87472e-09	1	0	A	63879798	A	A	63879798	3	1	105	1	0	0	0	0	1	0	0	0	522	826	29	2	917	2	ALG6	1	63879798	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	1207148	63879798	185370823	5	19712											
ECM1	1893	broad.mit.edu	37	chr1	150485926	150485926	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaatatcagctccacctctGagcccaaggaagaatgagtc	14	7	8	12	0	2	3	1	2	1	1	4	4	3	4	3	1	2	1	3	1	5	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:150485926G>C	uc001eus.2	+	10	1805	c.1606G>C	c.(1606-1608)GAG>CAG	p.E536Q	ECM1_uc001eut.2_Missense_Mutation_p.E411Q|ECM1_uc001euu.2_Missense_Mutation_p.E565Q|ECM1_uc001euv.2_Missense_Mutation_p.E563Q|ECM1_uc009wlu.2_Missense_Mutation_p.E296Q	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	536					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTCCACCTCTGAGCCCAAGGA	0.562													4	48					0	0	0	0	C	150485926	C	C	150485926	3	2	105	1	0	0	0	0	1	0	0	0	4919	1291	45	2	1644	2	ECM1	1	150485926	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	86606128	150485926	98764695	6	19713											
TRIM46	80128	broad.mit.edu	37	chr1	155152365	155152365	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgcaacaaggccggctacGgcgaatacagtgaagatgtg	12	6	14	9	3	0	2	0	1	0	1	0	3	0	2	1	3	4	3	1	3	6	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:155152365G>A	uc001fhs.1	+	8	1626	c.1543G>A	c.(1543-1545)GGC>AGC	p.G515S	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Missense_Mutation_p.G515S|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Missense_Mutation_p.G389S|TRIM46_uc001fhu.1_Missense_Mutation_p.G492S|TRIM46_uc009wpg.1_Missense_Mutation_p.G502S|TRIM46_uc001fhv.3_Missense_Mutation_p.G502S|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	515	Fibronectin type-III.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGCCGGCTACGGCGAATACAG	0.657													13	34					0	0	0	0	A	155152365	A	A	155152365	3	1	105	1	0	0	0	0	1	0	0	0	16588	1116	39	1	1573	1	TRIM46	1	155152365	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	4666439	155152365	94098256	7	19714											
CACNA1E	777	broad.mit.edu	37	chr1	181767596	181767596	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccacctgctgatggaagcGaggagggctccccgctgacc	7	6	13	15	2	0	2	0	2	0	0	2	5	2	4	5	3	2	3	5	3	1	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:181767596G>A	uc001gow.2	+	47	6604	c.6439G>A	c.(6439-6441)GAG>AAG	p.E2147K	CACNA1E_uc009wxs.2_Missense_Mutation_p.E2035K|CACNA1E_uc009wxt.2_Missense_Mutation_p.E1416K	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2190	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TGATGGAAGCGAGGAGGGCTC	0.642													23	50					0	0	0	0	A	181767596	A	A	181767596	3	1	105	1	0	0	0	0	1	0	0	0	2554	1059	37	1	6625	1	CACNA1E	1	181767596	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	26615231	181767596	67483025	8	19715											
PROX1	5629	broad.mit.edu	37	chr1	214171226	214171226	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgcaaaaactcctctgacCagtctgcctccggccctgcc	7	8	7	19	2	2	1	0	1	2	0	5	1	5	1	7	1	3	1	7	1	2	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:214171226C>A	uc001hkh.2	+	2	1620	c.1348C>A	c.(1348-1350)CAG>AAG	p.Q450K	PROX1_uc001hkg.1_Missense_Mutation_p.Q450K	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	450					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CTCCTCTGACCAGTCTGCCTC	0.642													32	71					6.38683e-12	2.69463e-11	1	0	A	214171226	A	A	214171226	3	1	105	1	0	0	0	0	1	0	0	0	12622	595	21	4	1350	4	PROX1	1	214171226	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	32403630	214171226	35079395	9	19716											
OBSCN	84033	broad.mit.edu	37	chr1	228437860	228437860	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcacacggaggctggtggtgCagcaggcatgccaggcggac	8	4	18	11	2	0	0	0	0	0	0	0	2	0	2	1	7	3	5	1	7	0	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:228437860C>T	uc009xez.1	+	14	4272	c.4228C>T	c.(4228-4230)CAG>TAG	p.Q1410*	OBSCN_uc001hsn.2_Nonsense_Mutation_p.Q1410*	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1410	Ig-like 14.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCTGGTGGTGCAGCAGGCATG	0.647													41	92					0	0	0	0	T	228437860	T	T	228437860	4	4	105	1	0	0	0	0	0	1	0	0	10866	711	25	4	4278	4	OBSCN	1	228437860	Nonsense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	14266634	228437860	20812761	10	19717											
CEP170	9859	broad.mit.edu	37	chr1	243333053	243333053	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttccagatgaagatgtgcCttcctaaaggagaaaaataa	16	9	9	7	0	0	4	0	1	0	3	2	5	2	4	3	1	1	1	3	1	6	4			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:243333053C>T	uc001hzs.2	-	12	2128	c.1720G>A	c.(1720-1722)GGC>AGC	p.G574S	CEP170_uc001hzt.2_Missense_Mutation_p.G476S|CEP170_uc001hzu.2_Missense_Mutation_p.G476S	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	574						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GAAGATGTGCCTTCCTAAAGG	0.383													6	20					0	0	0	0	T	243333053	T	T	243333053	3	4	105	1	0	0	0	0	1	0	0	0	3265	681	24	4	3100	4	CEP170	1	243333053	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	14895193	243333053	5917568	11	19718											
NLRP3	114548	broad.mit.edu	37	chr1	247588449	247588449	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggaaaactatggcaaattCgaaaaggggtatttgatttt	14	13	10	4	1	0	1	0	1	0	0	1	3	0	2	0	4	1	2	0	4	7	6			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr1:247588449C>T	uc001icr.2	+	5	1842	c.1704C>T	c.(1702-1704)TTC>TTT	p.F568F	NLRP3_uc001ics.2_Silent_p.F568F|NLRP3_uc001icu.2_Silent_p.F568F|NLRP3_uc001icw.2_Silent_p.F568F|NLRP3_uc001icv.2_Silent_p.F568F|NLRP3_uc010pyw.1_Silent_p.F566F|NLRP3_uc001ict.1_Silent_p.F566F	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	568					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ATGGCAAATTCGAAAAGGGGT	0.463													16	34					0	0	0	0	T	247588449	T	T	247588449	2	4	105	1	0	0	0	0	0	0	0	1	10532	883	31	1		1	NLRP3	1	247588449	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	4255396	247588449	1662172	12	19719											
GRHL1	29841	broad.mit.edu	37	chr2	10104143	10104143	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggaggtgagcagcagtgaagGaatccatcatcccatcagca	13	6	12	10	0	2	2	2	2	0	0	4	4	4	4	2	3	3	3	2	3	2	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr2:10104143G>A	uc002raa.2	+	6	1046	c.875G>A	c.(874-876)GGA>GAA	p.G292E	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.G103E|GRHL1_uc010yjb.1_Missense_Mutation_p.G141E	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	292					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		AGCAGTGAAGGAATCCATCAT	0.473													8	55					0	0	0	0	A	10104143	A	A	10104143	3	1	105	1	0	0	0	0	1	0	0	0	6802	1174	41	2	897	2	GRHL1	2	10104143	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08		10104143	233095230	13	19720											
DNMT3A	1788	broad.mit.edu	37	chr2	25469959	25469959	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctttgcggtacatgggctgCttgttgtacgtggcctggtg	3	14	16	8	2	0	0	0	0	0	0	0	0	0	0	1	4	4	6	1	4	2	5			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr2:25469959C>T	uc002rgc.2	-	9	1340	c.1083G>A	c.(1081-1083)AAG>AAA	p.K361K	DNMT3A_uc002rgd.2_Silent_p.K361K|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.K172K	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	361	Interaction with DNMT1 and DNMT3B.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACATGGGCTGCTTGTTGTACG	0.597			Mis|F|N|S		AML								16	26					0	0	0	0	T	25469959	T	T	25469959	2	4	105	1	0	0	0	0	0	0	0	1	4698	796	28	4		4	DNMT3A	2	25469959	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	15365816	25469959	217729414	14	19721											
SLC5A6	8884	broad.mit.edu	37	chr2	27430151	27430151	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcactggtgagatgcaggCggtagaaaacggggatgaag	13	5	18	5	2	0	3	0	2	0	2	0	5	0	4	0	6	2	3	0	6	4	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr2:27430151C>T	uc002rjd.2	-	3	759	c.368G>A	c.(367-369)CGC>CAC	p.R123H	SLC5A6_uc010eyv.1_Missense_Mutation_p.R123H|SLC5A6_uc002rje.1_Missense_Mutation_p.R123H	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	123					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	GAGATGCAGGCGGTAGAAAAC	0.557													14	29					0	0	0	0	T	27430151	T	T	27430151	3	4	105	1	0	0	0	0	1	0	0	0	14733	768	27	1	1599	1	SLC5A6	2	27430151	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	1960192	27430151	215769222	15	19722											
SCN1A	6323	broad.mit.edu	37	chr2	166904235	166904235	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcttgtgtagccataattggGatttctaccagctttcacac	9	14	8	10	0	2	0	1	0	1	0	2	1	2	1	2	1	3	3	2	1	3	7	rs121917923		TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr2:166904235G>T	uc010zcz.1	-	8	1090	c.1072C>A	c.(1072-1074)CCC>ACC	p.P358T	SCN1A_uc002udo.3_Missense_Mutation_p.P227T|SCN1A_uc010fpk.2_Missense_Mutation_p.P227T	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	358	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCATAATTGGGATTTCTACCA	0.408													24	68					9.86323e-18	4.36941e-17	1	0	T	166904235	T	T	166904235	3	4	105	1	0	0	0	0	1	0	0	0	13979	1174	41	2	5033	2	SCN1A	2	166904235	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	139474084	166904235	76295138	16	19723											
SCN7A	6332	broad.mit.edu	37	chr2	167298060	167298060	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaagtcatgcatgtgccagCgtgggagttgacagtctttg	10	11	13	7	1	2	1	1	1	1	0	2	2	2	2	1	1	3	2	1	1	2	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr2:167298060C>A	uc002udu.1	-	14	2130	c.2003G>T	c.(2002-2004)CGC>CTC	p.R668L	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	668					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						CATGTGCCAGCGTGGGAGTTG	0.458													15	46					6.49762e-13	2.79461e-12	1	0	A	167298060	A	A	167298060	3	1	105	1	0	0	0	0	1	0	0	0	13988	768	27	3	3093	3	SCN7A	2	167298060	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	393825	167298060	75901313	17	19724											
TTN	7273	broad.mit.edu	37	chr2	179474008	179474008	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgatcatatacagaccatgGtcaggtcggagagaatctcg	12	10	11	8	2	3	3	2	1	1	2	5	5	3	4	1	3	1	0	1	3	3	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr2:179474008G>C	uc010zfg.1	-	222	44549	c.44325C>G	c.(44323-44325)GAC>GAG	p.D14775E	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D8470E|TTN_uc010zfi.1_Missense_Mutation_p.D8403E|TTN_uc010zfj.1_Missense_Mutation_p.D8278E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15702							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGACCATGGTCAGGTCGGA	0.433													11	23					0	0	0	0	C	179474008	C	C	179474008	3	2	105	1	0	0	0	0	1	0	0	0	16803	1252	44	4	56024	4	TTN	2	179474008	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	12175948	179474008	63725365	18	19725											
TMEFF2	23671	broad.mit.edu	37	chr2	192922424	192922424	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagacatcctcggcatcttCgtcacattctgcaccaaact	10	10	5	16	2	3	1	1	0	2	1	6	1	4	1	3	1	2	2	3	1	1	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr2:192922424C>T	uc002utc.2	-	5	911	c.517G>A	c.(517-519)GAA>AAA	p.E173K		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	173	Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			TCGGCATCTTCGTCACATTCT	0.378													24	43					0	0	0	0	T	192922424	T	T	192922424	3	4	105	1	0	0	0	0	1	0	0	0	16080	893	31	1	631	1	TMEFF2	2	192922424	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	13448416	192922424	50276949	19	19726											
FN1	2335	broad.mit.edu	37	chr2	216240367	216240367	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttaccagtggaggcgtcgaTgaccacaggggagctccgag	9	6	16	10	3	0	1	0	1	0	0	2	5	1	3	3	4	2	2	3	4	1	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr2:216240367T>G	uc002vfa.2	-	37	6228	c.5962A>C	c.(5962-5964)ATC>CTC	p.I1988L	FN1_uc002vfb.2_Missense_Mutation_p.I1807L|FN1_uc002vfc.2_Missense_Mutation_p.I1807L|FN1_uc002vfd.2_Missense_Mutation_p.I1988L|FN1_uc002vfe.2_Missense_Mutation_p.I1897L|FN1_uc002vff.2_Missense_Mutation_p.I1897L|FN1_uc002vfg.2_Missense_Mutation_p.I1807L|FN1_uc002vfh.2_Missense_Mutation_p.I1807L|FN1_uc002vfi.2_Missense_Mutation_p.I1988L|FN1_uc002vfj.2_Missense_Mutation_p.I1898L|FN1_uc002vez.2_Missense_Mutation_p.I182L|FN1_uc010zjp.1_Missense_Mutation_p.I525L|FN1_uc002vfk.1_RNA|FN1_uc010fva.1_RNA|FN1_uc010fvb.1_RNA|FN1_uc010fvc.1_Missense_Mutation_p.I350L|FN1_uc010fvd.1_Intron	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1897	Binds to FBLN1.|Heparin-binding 2.|Fibronectin type-III 14.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGGCGTCGATGACCACAGGG	0.428													27	48					0	0	0	0	G	216240367	G	G	216240367	3	3	105	1	0	0	0	0	1	0	0	0	5994	1464	51	5	1511	5	FN1	2	216240367	Missense_Mutation	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	23317943	216240367	26959006	20	19727											
OR5H2	79310	broad.mit.edu	37	chr3	98002593	98002593	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcttttatacaatcataattCctttgctaaatcccattatc	12	18	1	10	0	2	0	1	0	1	0	5	0	4	0	2	0	2	1	2	0	7	8			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr3:98002593C>G	uc003dsj.1	+	1	862	c.862C>G	c.(862-864)CCT>GCT	p.P288A		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						AATCATAATTCCTTTGCTAAA	0.318													12	46					0	0	0	0	G	98002593	G	G	98002593	3	3	105	1	0	0	0	0	1	0	0	0	11216	855	30	2	864	2	OR5H2	3	98002593	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08		98002593	100019837	21	19728											
COPG	22820	broad.mit.edu	37	chr3	128993713	128993713	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagttactgtagctgatcaCattcaaaaggtcatgaaact	15	11	8	7	0	3	2	3	2	0	0	3	3	3	2	0	1	3	3	0	1	6	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr3:128993713C>T	uc003els.2	+	22	2389	c.2289C>T	c.(2287-2289)CAC>CAT	p.H763H	COPG_uc010htb.2_Silent_p.H669H	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	763	Interaction with ZNF289/ARFGAP2.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						TAGCTGATCACATTCAAAAGG	0.483													100	85					0	0	0	0	T	128993713	T	T	128993713	2	4	105	1	0	0	0	0	0	0	0	1	3746	477	17	4		4	COPG	3	128993713	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	30991120	128993713	69028717	22	19729											
COL6A6	131873	broad.mit.edu	37	chr3	130292872	130292872	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattcagccaaatgacttcaAgaaaatgaaggaatttctgg	16	10	8	7	0	3	3	2	2	1	1	3	4	3	4	1	2	1	0	1	2	6	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr3:130292872A>C	uc010htl.2	+	7	3081	c.3050A>C	c.(3049-3051)AAG>ACG	p.K1017T		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1017	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AATGACTTCAAGAAAATGAAG	0.408													11	47					0	0	0	0	C	130292872	C	C	130292872	3	2	105	1	0	0	0	0	1	0	0	0	3718	72	3	5	3076	5	COL6A6	3	130292872	Missense_Mutation	SNP	A	TCGA-CQ-6223-01A-11D-1912-08	1299159	130292872	67729558	23	19730											
TNK2	10188	broad.mit.edu	37	chr3	195594350	195594350	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccctgggttgctgttgttgGtggagaagttggccttgggg	3	13	18	7	0	0	1	0	0	0	1	0	2	0	1	3	6	1	5	3	6	1	5			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr3:195594350G>C	uc003fvu.1	-	12	3317	c.2774C>G	c.(2773-2775)ACC>AGC	p.T925S	TNK2_uc003fvq.1_Missense_Mutation_p.T332S|TNK2_uc003fvr.1_Missense_Mutation_p.T450S|TNK2_uc003fvs.1_Missense_Mutation_p.T957S|TNK2_uc003fvt.1_Missense_Mutation_p.T1003S|TNK2_uc010hzw.1_RNA	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	925	Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GCTGTTGTTGGTGGAGAAGTT	0.537													14	12					0	0	0	0	C	195594350	C	C	195594350	3	2	105	1	0	0	0	0	1	0	0	0	16384	1261	44	4	358	4	TNK2	3	195594350	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	65301478	195594350	2428080	24	19731											
LIMCH1	22998	broad.mit.edu	37	chr4	41699182	41699182	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgttttaatcacaggtgccGggcagcctacaacattgtga	10	12	10	9	1	1	1	1	1	0	0	1	1	1	1	2	2	4	2	2	2	3	5	rs142431467		TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr4:41699182G>T	uc003gvu.3	+	27	3286	c.3232G>T	c.(3232-3234)GGG>TGG	p.G1078W	LIMCH1_uc003gvv.3_Missense_Mutation_p.G1052W|LIMCH1_uc003gvw.3_Missense_Mutation_p.G1051W|LIMCH1_uc003gvx.3_Missense_Mutation_p.G1064W|LIMCH1_uc003gwe.3_Missense_Mutation_p.G975W|LIMCH1_uc003gvy.3_Missense_Mutation_p.G880W|LIMCH1_uc003gwa.3_Missense_Mutation_p.G892W|LIMCH1_uc003gvz.3_Missense_Mutation_p.G1462W|LIMCH1_uc011byu.1_Missense_Mutation_p.G911W|LIMCH1_uc003gwc.3_Missense_Mutation_p.G897W|LIMCH1_uc003gwd.3_Missense_Mutation_p.G885W|LIMCH1_uc011byv.1_Missense_Mutation_p.G828W|LIMCH1_uc011byw.1_Missense_Mutation_p.G351W|LIMCH1_uc010ifv.2_RNA	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	1078					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						CACAGGTGCCGGGCAGCCTAC	0.453													21	71					7.88262e-20	3.56327e-19	1	0	T	41699182	T	T	41699182	3	4	105	1	0	0	0	0	1	0	0	0	8838	1116	39	3	3366	3	LIMCH1	4	41699182	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08		41699182	149455094	25	19732											
EPHA5	2044	broad.mit.edu	37	chr4	66361109	66361109	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgtgggtttccttacttgTgcatgccattgtgggtggat	4	16	13	8	1	0	0	0	0	0	0	2	1	2	1	3	3	3	2	3	3	1	4			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr4:66361109T>C	uc003hcy.2	-	4	1256	c.1063A>G	c.(1063-1065)ACA>GCA	p.T355A	EPHA5_uc003hcx.2_Missense_Mutation_p.T286A|EPHA5_uc003hcz.2_Missense_Mutation_p.T355A|EPHA5_uc011cah.1_Missense_Mutation_p.T355A|EPHA5_uc011cai.1_Missense_Mutation_p.T355A|EPHA5_uc003hda.2_Missense_Mutation_p.T355A	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	355	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TCCTTACTTGTGCATGCCATT	0.438										TSP Lung(17;0.13)			62	87					0	0	0	0	C	66361109	C	C	66361109	3	2	105	1	0	0	0	0	1	0	0	0	5194	1696	59	5	2110	5	EPHA5	4	66361109	Missense_Mutation	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	24661927	66361109	124793167	26	19733											
ANTXR2	118429	broad.mit.edu	37	chr4	80993706	80993706	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgggccggggaccgctcCgccaccatcctgcggccggg	3	4	16	18	6	0	0	0	0	0	0	2	1	2	1	7	5	2	1	7	5	0	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr4:80993706C>T	uc003hlz.3	-	1	772	c.9G>A	c.(7-9)GCG>GCA	p.A3A	ANTXR2_uc003hly.3_Silent_p.A3A|ANTXR2_uc003hlx.1_5'Flank|ANTXR2_uc010ijn.2_Silent_p.A3A	NM_001145794	NP_001139266	P58335	ANTR2_HUMAN	anthrax toxin receptor 2 isoform 2	3						endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			ovary(1)	1						GGGACCGCTCCGCCACCATCC	0.746									Juvenile_Hyaline_Fibromatosis				5	5					0	0	0	0	T	80993706	T	T	80993706	2	4	105	1	0	0	0	0	0	0	0	1	712	639	23	1		1	ANTXR2	4	80993706	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	14632597	80993706	110160570	27	19734											
UNC5C	8633	broad.mit.edu	37	chr4	96141216	96141216	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatatctgactcaaagtcaCgatgattcttccgatacaca	14	12	5	10	2	4	2	2	2	2	0	5	4	5	2	1	0	1	0	1	0	4	5	rs150089453		TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr4:96141216C>T	uc003htp.1	-	8	1374	c.1220G>A	c.(1219-1221)CGT>CAT	p.R407H	UNC5C_uc010ilc.1_Missense_Mutation_p.R426H|UNC5C_uc003htq.2_Missense_Mutation_p.R426H	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	407	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CTCAAAGTCACGATGATTCTT	0.458													20	44					0	0	0	0	T	96141216	T	T	96141216	3	4	105	1	0	0	0	0	1	0	0	0	17061	536	19	1	1611	1	UNC5C	4	96141216	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	15147510	96141216	95013060	28	19735											
FAT1	2195	broad.mit.edu	37	chr4	187584693	187584693	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaaagaggcacgacaccctGatcggttgcaaagactgtta	13	8	11	9	2	0	4	0	2	0	2	1	5	0	4	1	2	1	4	1	2	3	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr4:187584693G>A	uc003izf.2	-	3	3528	c.3340C>T	c.(3340-3342)CAG>TAG	p.Q1114*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1114	Extracellular (Potential).|Cadherin 9.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACGACACCCTGATCGGTTGCA	0.448										HNSCC(5;0.00058)			27	53					0	0	0	0	A	187584693	A	A	187584693	4	1	105	1	0	0	0	0	0	1	0	0	5721	1299	45	2	10526	2	FAT1	4	187584693	Nonsense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	91443477	187584693	3569583	29	19736											
RAB3C	115827	broad.mit.edu	37	chr5	57913562	57913562	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttactcatcatcggcaatagCagtgtggggaaaacatcttt	12	12	9	8	1	3	0	2	0	1	0	4	1	3	1	0	3	3	2	0	3	5	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr5:57913562C>A	uc003jrp.2	+	2	214	c.117C>A	c.(115-117)AGC>AGA	p.S39R		NM_138453	NP_612462	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	39	GTP (By similarity).				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)|central_nervous_system(1)	2		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		TCGGCAATAGCAGTGTGGGGA	0.428													12	41					0.000978159	0.00364138	1	0	A	57913562	A	A	57913562	3	1	105	1	0	0	0	0	1	0	0	0	12998	709	25	4	123	4	RAB3C	5	57913562	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08		57913562	123001698	30	19737											
ANKRD32	84250	broad.mit.edu	37	chr5	94027884	94027884	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtagatctgctcactcaagTggacggggtgactcctttgc	7	11	13	10	1	3	2	2	1	1	1	4	3	4	3	1	4	2	2	1	4	2	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr5:94027884T>C	uc003kkr.3	+	20	2698	c.2618T>C	c.(2617-2619)GTG>GCG	p.V873A	ANKRD32_uc003kks.2_Missense_Mutation_p.V237A	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	873										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CTCACTCAAGTGGACGGGGTG	0.493													23	61					0	0	0	0	C	94027884	C	C	94027884	3	2	105	1	0	0	0	0	1	0	0	0	660	1696	59	5	2692	5	ANKRD32	5	94027884	Missense_Mutation	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	36114322	94027884	86887376	31	19738											
SMAD5	4090	broad.mit.edu	37	chr5	135513140	135513140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttactcagatgggctcccCtctgaaccccatatcttctg	7	12	6	16	0	4	2	1	1	3	1	5	2	5	2	5	1	2	1	5	1	3	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr5:135513140C>T	uc003lbj.1	+	11	1814	c.1370C>T	c.(1369-1371)CCT>CTT	p.P457L	SMAD5_uc003lbk.1_Missense_Mutation_p.P457L|SMAD5_uc003lbl.1_Missense_Mutation_p.P457L	NM_001001419	NP_001001419	Q99717	SMAD5_HUMAN	SMAD family member 5	457	MH2.				BMP signaling pathway|embryonic pattern specification|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATGGGCTCCCCTCTGAACCCC	0.398													5	12					0	0	0	0	T	135513140	T	T	135513140	3	4	105	1	0	0	0	0	1	0	0	0	14825	681	24	4	1391	4	SMAD5	5	135513140	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	41485256	135513140	45402120	32	19739											
PCDHGA9	56107	broad.mit.edu	37	chr5	140784241	140784241	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccactgatggttctactggTgtggagctggcaccccgctc	5	10	12	14	1	1	1	0	1	1	0	2	2	1	2	3	4	2	4	3	4	1	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr5:140784241T>C	uc003lkh.1	+	1	1722	c.1722T>C	c.(1720-1722)GGT>GGC	p.G574G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Silent_p.G574G	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	574	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCTACTGGTGTGGAGCTGG	0.562													43	114					0	0	0	0	C	140784241	C	C	140784241	2	2	105	1	0	0	0	0	0	0	0	1	11615	1683	59	5		5	PCDHGA9	5	140784241	Silent	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	5271101	140784241	40131019	33	19740											
CSNK1A1	1452	broad.mit.edu	37	chr5	148899953	148899953	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcaattctactgatcatcTggaaaaaaaagaagggagag	18	9	9	5	0	4	3	2	1	2	2	4	5	4	4	0	2	1	0	0	2	7	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr5:148899953T>C	uc003lqx.1	-	4	838	c.358_splice	c.e4-1	p.M120_splice	CSNK1A1_uc011dcb.1_Splice_Site_p.M1_splice|CSNK1A1_uc011dcc.1_Splice_Site_p.M31_splice|CSNK1A1_uc003lqv.1_Splice_Site_p.M31_splice|CSNK1A1_uc003lqw.1_Splice_Site_p.M120_splice|CSNK1A1_uc003lqy.1_Splice_Site_p.M120_splice|CSNK1A1_uc010jha.1_Splice_Site_p.M120_splice	NM_001892	NP_001883	P48729	KC1A_HUMAN	casein kinase 1, alpha 1 isoform 2						cell division|mitosis|Wnt receptor signaling pathway	centrosome|condensed chromosome kinetochore|cytosol|nuclear speck	ATP binding|protein binding|protein binding|protein serine/threonine kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		ACTGATCATCTGGAAAAAAAA	0.303													20	28					0	0	0	0	C	148899953	C	C	148899953	5	2	105	1	0	0	0	0	0	0	1	0	3967	1594	55	5	773	5	CSNK1A1	5	148899953	Splice_Site	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	8115712	148899953	32015307	34	19741											
GALNT10	55568	broad.mit.edu	37	chr5	153789255	153789255	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtttcaagtggtttatgaCgaagatagcctgggacctgc	10	11	13	7	1	1	2	1	1	0	1	1	5	1	3	2	2	2	2	2	2	4	4	rs147745456		TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr5:153789255C>T	uc003lvh.2	+	9	1451	c.1319C>T	c.(1318-1320)ACG>ATG	p.T440M	GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Missense_Mutation_p.T281M|uc003lvi.2_Intron|GALNT10_uc003lvj.2_Missense_Mutation_p.T111M	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	440	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			tggTTTATGACGAAGATAGCC	0.303													35	81					0	0	0	0	T	153789255	T	T	153789255	3	4	105	1	0	0	0	0	1	0	0	0	6243	536	19	1	1353	1	GALNT10	5	153789255	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	4889302	153789255	27126005	35	19742											
DOCK2	1794	broad.mit.edu	37	chr5	169474561	169474561	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatgaaaatcctcaggccCaaaccagactactttgctgt	13	10	6	12	0	2	2	2	1	0	1	3	2	3	2	3	1	3	1	3	1	4	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr5:169474561C>A	uc003maf.2	+	40	4094	c.4014C>A	c.(4012-4014)CCC>CCA	p.P1338P	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.P830P	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1338	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTCAGGCCCAAACCAGACT	0.498													10	45					0.000673444	0.00254988	1	0	A	169474561	A	A	169474561	2	1	105	1	0	0	0	0	0	0	0	1	4709	581	21	4		4	DOCK2	5	169474561	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	15685306	169474561	11440699	36	19743											
SH3PXD2B	285590	broad.mit.edu	37	chr5	171809084	171809084	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtcttgtctcaaagaactgCagcacctcatcacactgaga	12	9	8	12	0	4	2	3	1	2	2	5	3	4	2	1	1	3	2	1	1	2	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr5:171809084C>A	uc003mbr.2	-	5	528	c.357G>T	c.(355-357)CTG>CTT	p.L119L	SH3PXD2B_uc003mbs.1_Silent_p.L119L	NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	119	PX.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAAAGAACTGCAGCACCTCAT	0.547													9	14					0.000978159	0.00364138	1	0	A	171809084	A	A	171809084	2	1	105	1	0	0	0	0	0	0	0	1	14322	697	25	4		4	SH3PXD2B	5	171809084	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	2334523	171809084	9106176	37	19744											
RREB1	6239	broad.mit.edu	37	chr6	7229324	7229324	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttccccatgctctgctcacTggctctgcacaagcagaccc	7	9	8	17	0	3	1	1	0	2	1	4	1	4	1	3	1	4	6	3	1	1	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr6:7229324T>G	uc003mxc.2	+	10	1382	c.992T>G	c.(991-993)CTG>CGG	p.L331R	RREB1_uc003mxb.2_Missense_Mutation_p.L331R|RREB1_uc010jnx.2_Missense_Mutation_p.L331R	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	331	C2H2-type 6.				multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CTCTGCTCACTGGCTCTGCAC	0.607													16	21					0	0	0	0	G	7229324	G	G	7229324	3	3	105	1	0	0	0	0	1	0	0	0	13744	1580	55	5	1018	5	RREB1	6	7229324	Missense_Mutation	SNP	T	TCGA-CQ-6223-01A-11D-1912-08		7229324	163885743	38	19745											
ZNRD1	30834	broad.mit.edu	37	chr6	30029436	30029436	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcgctgtggcttcaacatCaacgttcggggtgagaggct	8	11	13	9	3	2	1	2	1	0	1	4	2	2	1	0	4	2	4	0	4	2	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr6:30029436C>A	uc003noz.2	+	2	285	c.135C>A	c.(133-135)ATC>ATA	p.I45I	NCRNA00171_uc011dme.1_5'Flank|NCRNA00171_uc003nox.1_5'Flank|NCRNA00171_uc003rto.2_5'Flank|ZNRD1_uc003npa.2_Silent_p.I45I	NM_014596	NP_055411	Q9P1U0	RPA12_HUMAN	zinc ribbon domain containing 1	45						nucleolus	DNA-directed RNA polymerase activity|nucleic acid binding|zinc ion binding				0						GCTTCAACATCAACGTTCGGG	0.602													14	68					6.31663e-08	2.54388e-07	1	0	A	30029436	A	A	30029436	2	1	105	1	0	0	0	0	0	0	0	1	18277	816	29	2		2	ZNRD1	6	30029436	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	22800112	30029436	141085631	39	19746											
CSNK2B	1460	broad.mit.edu	37	chr6	31636415	31636415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctacatccttaccaaccGtggcatcgcccagatggtga	9	8	9	15	3	0	2	0	1	0	1	2	2	1	2	5	2	3	2	5	2	3	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr6:31636415G>A	uc003nvr.1	+	4	615	c.275G>A	c.(274-276)CGT>CAT	p.R92H	BAT4_uc003nvo.3_5'Flank|BAT4_uc003nvp.3_5'Flank|BAT4_uc003nvq.2_5'Flank|CSNK2B_uc010jta.1_3'UTR|CSNK2B_uc003nvs.1_Missense_Mutation_p.R92H|LY6G5B_uc003nvt.1_5'Flank	NM_001320	NP_001311	P67870	CSK2B_HUMAN	casein kinase 2, beta polypeptide	92					adiponectin-mediated signaling pathway|axon guidance|cellular protein complex assembly|negative regulation of cell proliferation|regulation of DNA binding|Wnt receptor signaling pathway	cytosol|nucleus|protein kinase CK2 complex	identical protein binding|protein domain specific binding|protein kinase regulator activity|receptor binding|transcription factor binding				0						CTTACCAACCGTGGCATCGCC	0.537													21	35					0	0	0	0	A	31636415	A	A	31636415	3	1	105	1	0	0	0	0	1	0	0	0	3976	1145	40	1	285	1	CSNK2B	6	31636415	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	1606979	31636415	139478652	40	19747											
KIAA1919	91749	broad.mit.edu	37	chr6	111583600	111583600	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgattggtggatttcttgtCgatgtcatgaattatttttt	7	21	10	3	1	2	2	1	2	1	0	3	4	2	3	0	2	0	0	0	2	2	7			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr6:111583600C>A	uc003puv.3	+	2	590	c.168C>A	c.(166-168)GTC>GTA	p.V56V		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	56	Helical; (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		GATTTCTTGTCGATGTCATGA	0.348													39	85					1.15505e-17	5.0662e-17	1	0	A	111583600	A	A	111583600	2	1	105	1	0	0	0	0	0	0	0	1	8301	871	31	3		3	KIAA1919	6	111583600	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	79947185	111583600	59531467	41	19748											
RAC1	5879	broad.mit.edu	37	chr7	6426850	6426850	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctttctctttagagctgtaGgtaaaacttgcctactgatc	9	16	7	9	0	2	2	0	1	2	1	4	2	2	2	1	1	4	3	1	1	5	7			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr7:6426850G>A	uc003spx.2	+	2	284	c.43G>A	c.(43-45)GGT>AGT	p.G15S	RAC1_uc003spw.2_Missense_Mutation_p.G15S	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	15	GTP (By similarity).				actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	TAGAGCTGTAGGTAAAACTTG	0.318													23	70					0	0	0	0	A	6426850	A	A	6426850	3	1	105	1	0	0	0	0	1	0	0	0	13039	1000	35	4	49	4	RAC1	7	6426850	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08		6426850	152711813	42	19749											
CPVL	54504	broad.mit.edu	37	chr7	29035468	29035468	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tctcagaggctggtcataggGtaaaatatgtcctccacctc	10	11	9	11	0	2	1	2	0	1	1	6	1	4	1	3	3	0	2	3	3	4	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr7:29035468G>A	uc003szv.2	-	13	1470	c.1351C>T	c.(1351-1353)CCC>TCC	p.P451S	CPVL_uc003szw.2_Missense_Mutation_p.P451S|CPVL_uc003szx.2_Missense_Mutation_p.P451S	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	451					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						TGGTCATAGGGTAAAATATGT	0.333													14	21					0	0	0	0	A	29035468	A	A	29035468	3	1	105	1	0	0	0	0	1	0	0	0	3850	1261	44	4	83	4	CPVL	7	29035468	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	22608618	29035468	130103195	43	19750											
LMTK2	22853	broad.mit.edu	37	chr7	97821070	97821070	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtggaacgctctgaagccGaacacaaacagcagagactc	15	4	10	12	2	1	2	0	1	1	1	2	5	1	3	1	1	5	2	1	1	4	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr7:97821070G>A	uc003upd.1	+	11	1586	c.1293G>A	c.(1291-1293)CCG>CCA	p.P431P		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	431					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CTCTGAAGCCGAACACAAACA	0.577													14	40					0	0	0	0	A	97821070	A	A	97821070	2	1	105	1	0	0	0	0	0	0	0	1	8901	1045	37	1		1	LMTK2	7	97821070	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	68785602	97821070	61317593	44	19751											
SERPINE1	5054	broad.mit.edu	37	chr7	100777046	100777047	+	Frame_Shift_Ins	INS	-	A	A																															accacggggacaccctcagcINSatgttcattgctgcccctta																										TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr7:100777046_100777047insA	uc003uxt.2	+	5	919_920	c.771_772insA	c.(769-774)AGCATGfs	p.S257fs	SERPINE1_uc011kkj.1_Frame_Shift_Ins_p.S242fs|SERPINE1_uc003uxu.1_Frame_Shift_Ins_p.S88fs	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	257_258					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	ACACCCTCAGCATGTTCATTGC	0.54													---	---	---								A	100777047	A	A	100777046	7	5	105	1	0	1	1	0	0	0	0	0	14176	709	25	0	785	0	SERPINE1	7	100777046	Frame_Shift_Ins	INS	-	TCGA-CQ-6223-01A-11D-1912-08	2955976	100777046	58361617	45	19752											
FSCN3	29999	broad.mit.edu	37	chr7	127235813	127235813	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctctacacaccacttcttGtcccatgtagaccggctgtt	8	12	6	15	1	2	1	0	0	2	1	3	1	3	1	4	1	1	3	4	1	2	5	rs150163324		TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr7:127235813G>C	uc003vmd.1	+	2	816	c.597G>C	c.(595-597)TTG>TTC	p.L199F	FSCN3_uc003vmc.1_Missense_Mutation_p.L154F|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_Missense_Mutation_p.L65F|FSCN3_uc010llc.1_Missense_Mutation_p.L199F	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	199						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						ACCACTTCTTGTCCCATGTAG	0.562													21	61					0	0	0	0	C	127235813	C	C	127235813	3	2	105	1	0	0	0	0	1	0	0	0	6103	1368	48	4	603	4	FSCN3	7	127235813	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	26458767	127235813	31902850	46	19753											
C7orf49	78996	broad.mit.edu	37	chr7	134853603	134853603	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttcattggtgccacattCtttgtagccacctgggctgt	5	14	10	12	0	2	0	1	0	1	0	2	0	2	0	4	2	2	2	4	2	1	5			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr7:134853603C>G	uc003vsl.2	-	2	339	c.72G>C	c.(70-72)AAG>AAC	p.K24N	C7orf49_uc003vsh.2_Missense_Mutation_p.E10Q|C7orf49_uc003vsj.2_5'Flank|C7orf49_uc003vsk.2_RNA|C7orf49_uc003vsm.2_RNA|C7orf49_uc003vsn.2_Missense_Mutation_p.E10Q|C7orf49_uc003vso.2_Intron	NM_024033	NP_076938	Q9BWK5	MRI_HUMAN	modulator of retrovirus infection	24						cytoplasm				large_intestine(1)|ovary(1)	2						GTGCCACATTCTTTGTAGCCA	0.532											OREG0018340	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	134					0	0	0	0	G	134853603	G	G	134853603	3	3	105	1	0	0	0	0	1	0	0	0	2409	912	32	2	413	2	C7orf49	7	134853603	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	7617790	134853603	24285060	47	19754											
FGFR1	2260	broad.mit.edu	37	chr8	38283759	38283759	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgatgctccaggtggcataaCggacctgaggggaaatgcca	11	7	14	9	1	0	2	0	2	0	0	1	4	1	4	3	5	3	2	3	5	2	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr8:38283759C>T	uc003xlp.2	-	6	1568	c.626G>A	c.(625-627)CGT>CAT	p.R209H	FGFR1_uc011lbo.1_Missense_Mutation_p.R207H|FGFR1_uc011lbp.1_Missense_Mutation_p.R120H|FGFR1_uc011lbq.1_Missense_Mutation_p.R118H|FGFR1_uc010lwk.2_Missense_Mutation_p.R201H|FGFR1_uc011lbr.1_RNA|FGFR1_uc011lbs.1_Missense_Mutation_p.R49H|FGFR1_uc011lbt.1_Missense_Mutation_p.R118H|FGFR1_uc011lbu.1_Missense_Mutation_p.R240H|FGFR1_uc011lbv.1_Missense_Mutation_p.R207H|FGFR1_uc011lbw.1_Missense_Mutation_p.R120H|FGFR1_uc011lbx.1_Missense_Mutation_p.R120H|FGFR1_uc003xlv.2_Missense_Mutation_p.R120H|FGFR1_uc003xlu.2_Missense_Mutation_p.R118H|FGFR1_uc003xlw.1_RNA	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	209	Extracellular (Potential).|Ig-like C2-type 2.				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	GGTGGCATAACGGACCTGAGG	0.542		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						49	143					0	0	0	0	T	38283759	T	T	38283759	3	4	105	1	0	0	0	0	1	0	0	0	5895	536	19	1	2134	1	FGFR1	8	38283759	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08		38283759	108080263	48	19755											
ADAM2	2515	broad.mit.edu	37	chr8	39624564	39624564	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctttcttttgacataaacTgatgggatgaggtaaatgat	12	16	9	4	0	2	4	0	4	2	0	2	5	2	5	0	2	1	1	0	2	4	6			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr8:39624564T>C	uc003xnj.2	-	14	1387	c.1312_splice	c.e14-1	p.F438_splice	ADAM2_uc003xnk.2_Splice_Site_p.F419_splice|ADAM2_uc011lck.1_Splice_Site_p.F438_splice|ADAM2_uc003xnl.2_Splice_Site_p.F312_splice	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein						cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TGACATAAACTGATGGGATGA	0.333													31	60					0	0	0	0	C	39624564	C	C	39624564	5	2	105	1	0	0	0	0	0	0	1	0	241	1594	55	5	925	5	ADAM2	8	39624564	Splice_Site	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	1340805	39624564	106739458	49	19756											
ST18	9705	broad.mit.edu	37	chr8	53055565	53055565	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagaggcctctccaggaaacTttttttcctctaaattttct	9	17	5	10	0	3	1	0	0	3	1	5	2	4	2	3	2	1	0	3	2	4	7			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr8:53055565T>A	uc003xqz.2	-	12	2249	c.2093A>T	c.(2092-2094)AAG>ATG	p.K698M	ST18_uc011ldq.1_Missense_Mutation_p.K345M|ST18_uc011ldr.1_Missense_Mutation_p.K663M|ST18_uc011lds.1_Missense_Mutation_p.K603M|ST18_uc003xra.2_Missense_Mutation_p.K698M	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	698						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCCAGGAAACTTTTTTTCCTC	0.408													20	53					0	0	0	0	A	53055565	A	A	53055565	3	1	105	1	0	0	0	0	1	0	0	0	15278	1609	56	5	1090	5	ST18	8	53055565	Missense_Mutation	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	13431001	53055565	93308457	50	19757											
GLI4	2738	broad.mit.edu	37	chr8	144358450	144358450	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctgctcctgaagcaccagCgcatccacacgggcgagaag	10	4	12	15	4	0	2	0	1	0	1	2	3	2	2	3	1	3	4	3	1	2	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr8:144358450C>T	uc003yxx.2	+	4	692	c.607C>T	c.(607-609)CGC>TGC	p.R203C	ZFP41_uc003yxv.2_RNA	NM_138465	NP_612474	P10075	GLI4_HUMAN	GLI-Kruppel family member GLI4	203	C2H2-type 1.					nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GAAGCACCAGCGCATCCACAC	0.687													6	15					0	0	0	0	T	144358450	T	T	144358450	3	4	105	1	0	0	0	0	1	0	0	0	6477	768	27	1	617	1	GLI4	8	144358450	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	91302885	144358450	2005572	51	19758											
C9orf150	286343	broad.mit.edu	37	chr9	12775787	12775787	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaagtacccgagagtctaGtgcgctctctccgtggggag	8	8	14	11	3	2	1	0	0	2	1	4	3	3	2	2	2	2	3	2	2	3	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr9:12775787G>T	uc003zkw.2	+	1	776	c.73G>T	c.(73-75)GTG>TTG	p.V25L		NM_203403	NP_981948	Q8IV03	CI150_HUMAN	hypothetical protein LOC286343	25											0				GBM - Glioblastoma multiforme(1;1.64e-13)		CGAGAGTCTAGTGCGCTCTCT	0.498													7	22					0.00198382	0.00726307	1	0	T	12775787	T	T	12775787	3	4	105	1	0	0	0	0	1	0	0	0	2474	1029	36	4	75	4	C9orf150	9	12775787	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08		12775787	128437644	52	19759											
DRGX	644168	broad.mit.edu	37	chr10	50594749	50594749	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgggcctccagcgcctcCttcttactccgggcttggtc	2	12	11	16	2	1	0	0	0	1	0	5	0	4	0	5	3	3	2	5	3	1	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr10:50594749C>G	uc010qgq.1	-	4	405	c.405G>C	c.(403-405)AAG>AAC	p.K135N		NM_001080520	NP_001073989	A6NNA5	DRGX_HUMAN	dorsal root ganglia homeobox	135					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCAGCGCCTCCTTCTTACTCC	0.642													20	33					0	0	0	0	G	50594749	G	G	50594749	3	3	105	1	0	0	0	0	1	0	0	0	4785	680	24	4	412	4	DRGX	10	50594749	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08		50594749	84939998	53	19760											
AGAP7	653268	broad.mit.edu	37	chr10	51464881	51464881	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgggttttgtccgcccctgGctgctcccttcccagatgct	2	13	11	15	1	0	1	0	0	0	1	3	1	3	1	5	2	2	4	5	2	0	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr10:51464881G>A	uc001jio.2	-	7	1701	c.1575C>T	c.(1573-1575)AGC>AGT	p.S525S	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron	NM_001077685	NP_001071153	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	525	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						TCCGCCCCTGGCTGCTCCCTT	0.537													6	193					0	0	0	0	A	51464881	A	A	51464881	2	1	105	1	0	0	0	0	0	0	0	1	373	1194	42	4		4	AGAP7	10	51464881	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	870132	51464881	84069866	54	19761											
PRF1	5551	broad.mit.edu	37	chr10	72358804	72358804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccacccagctccacagcccGgatgaagtgggtgccgtagt	8	6	13	14	2	0	1	0	1	0	0	1	2	1	2	5	2	3	2	5	2	2	1	rs28933973		TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr10:72358804G>A	uc009xqg.2	-	3	834	c.673C>T	c.(673-675)CGG>TGG	p.R225W	PRF1_uc001jrf.3_Missense_Mutation_p.R225W	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	225	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TCCACAGCCCGGATGAAGTGG	0.657			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				13	35					0	0	0	0	A	72358804	A	A	72358804	3	1	105	1	0	0	0	0	1	0	0	0	12540	1115	39	1	998	1	PRF1	10	72358804	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	20893923	72358804	63175943	55	19762											
NOC3L	64318	broad.mit.edu	37	chr10	96122691	96122693	+	5'Flank	DEL	ACT	-	-																															acacgtgccgaagtccctacActaccagagccggaaacggc																										TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr10:96122691_96122693delACT	uc001kjq.1	-						NOC3L_uc009xuk.1_5'Flank	NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog							nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				AAGTCCCTACACTACCAGAGCCG	0.591											OREG0020385	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	96122693	-	-	96122691	6	5	105	0	1	1	0	1	0	0	0	0	10568	174	6	0		0	NOC3L	10	96122691	5'Flank	DEL	ACT	TCGA-CQ-6223-01A-11D-1912-08	23763887	96122691	39412056	56	19763											
TMEM180	79847	broad.mit.edu	37	chr10	104229810	104229810	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggttggctcagtgaccggCagttcctcagctcccagccc	5	9	11	16	2	2	1	2	1	0	0	5	1	4	1	4	3	2	5	4	3	0	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr10:104229810C>A	uc001kvt.2	+	4	448	c.229C>A	c.(229-231)CAG>AAG	p.Q77K	TMEM180_uc001kvs.2_Missense_Mutation_p.Q77K|TMEM180_uc010qql.1_5'UTR|TMEM180_uc010qqm.1_Missense_Mutation_p.Q77K|TMEM180_uc001kvu.2_Missense_Mutation_p.Q77K	NM_024789	NP_079065	Q14CX5	TM180_HUMAN	transmembrane protein 180	77						integral to membrane				ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CAGTGACCGGCAGTTCCTCAG	0.592													20	20					1.37657e-19	6.15978e-19	1	0	A	104229810	A	A	104229810	3	1	105	1	0	0	0	0	1	0	0	0	16165	711	25	4	235	4	TMEM180	10	104229810	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	8107119	104229810	31304937	57	19764											
CDHR5	53841	broad.mit.edu	37	chr11	621590	621590	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcctggagggtgtagaacAgaatgtcgtccttgtcgcgg	7	12	14	8	3	0	2	0	0	0	2	4	3	2	3	2	3	1	1	2	3	3	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr11:621590A>C	uc001lqj.2	-	5	584	c.479T>G	c.(478-480)CTG>CGG	p.L160R	CDHR5_uc001lqk.2_Missense_Mutation_p.L160R|CDHR5_uc009ycc.2_5'UTR|CDHR5_uc009ycd.2_Missense_Mutation_p.L160R|CDHR5_uc001lql.2_Missense_Mutation_p.L160R|CDHR5_uc001lqm.2_5'UTR|CDHR5_uc009yce.1_Missense_Mutation_p.L129R	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	160	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						GGTGTAGAACAGAATGTCGTC	0.647													23	73					0	0	0	0	C	621590	C	C	621590	3	2	105	1	0	0	0	0	1	0	0	0	3137	188	7	5	2102	5	CDHR5	11	621590	Missense_Mutation	SNP	A	TCGA-CQ-6223-01A-11D-1912-08		621590	134384926	58	19765											
CPT1A	1374	broad.mit.edu	37	chr11	68562283	68562283	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttgcctactggtttgatttCctcccggtccagtttgcgcc	3	16	9	13	2	0	1	0	1	0	0	3	1	3	1	5	2	3	2	5	2	1	5			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr11:68562283C>T	uc001oog.3	-	8	1038	c.868G>A	c.(868-870)GAA>AAA	p.E290K	CPT1A_uc001oof.3_Missense_Mutation_p.E290K|CPT1A_uc009ysj.2_Missense_Mutation_p.E290K	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	290	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GGTTTGATTTCCTCCCGGTCC	0.328													32	66					0	0	0	0	T	68562283	T	T	68562283	3	4	105	1	0	0	0	0	1	0	0	0	3846	864	30	2	1541	2	CPT1A	11	68562283	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	67940693	68562283	66444233	59	19766											
ABCG4	64137	broad.mit.edu	37	chr11	119029297	119029297	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctacggttcatgtcccacGtggttattggcgtgctcatc	6	13	10	12	3	2	0	2	0	0	0	4	0	3	0	2	3	2	3	2	3	2	4			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr11:119029297G>A	uc001pvs.2	+	11	1534	c.1198G>A	c.(1198-1200)GTG>ATG	p.V400M	ABCG4_uc009zar.2_Missense_Mutation_p.V400M	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	400	ABC transmembrane type-2.|Helical; Name=1; (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CATGTCCCACGTGGTTATTGG	0.562													57	156					0	0	0	0	A	119029297	A	A	119029297	3	1	105	1	0	0	0	0	1	0	0	0	70	1145	40	1	1236	1	ABCG4	11	119029297	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	50467014	119029297	15977219	60	19767											
CBL	867	broad.mit.edu	37	chr11	119169109	119169109	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccatgccaacactggtcccGaggagtcagaaaatgaggat	13	6	11	11	1	1	2	1	1	0	1	2	5	2	4	3	3	2	0	3	3	3	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr11:119169109G>A	uc001pwe.2	+	15	2431	c.2293G>A	c.(2293-2295)GAG>AAG	p.E765K		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	765	Interaction with CD2AP.|Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CACTGGTCCCGAGGAGTCAGA	0.507									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				14	64					0	0	0	0	A	119169109	A	A	119169109	3	1	105	1	0	0	0	0	1	0	0	0	2712	1059	37	1	2351	1	CBL	11	119169109	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	139812	119169109	15837407	61	19768											
OR6T1	219874	broad.mit.edu	37	chr11	123813951	123813951	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caacgtagagagcatgaaagCcaccagtttcagcaggtggg	13	6	13	9	1	1	2	1	1	0	1	1	3	1	2	2	2	4	4	2	2	3	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr11:123813951C>A	uc010sab.1	-	1	595	c.595G>T	c.(595-597)GCT>TCT	p.A199S		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		AGCATGAAAGCCACCAGTTTC	0.547													23	45					2.21704e-12	9.44372e-12	1	0	A	123813951	A	A	123813951	3	1	105	1	0	0	0	0	1	0	0	0	11264	739	26	4	379	4	OR6T1	11	123813951	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	4644842	123813951	11192565	62	19769											
VWA5A	4013	broad.mit.edu	37	chr11	123993788	123993788	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgctcgggaagtatgcagagCcccatgagtagccaggatac	11	6	13	11	2	0	2	0	1	0	1	1	4	0	4	3	2	4	4	3	2	4	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr11:123993788C>T	uc001pzu.2	+	8	1091	c.882C>T	c.(880-882)AGC>AGT	p.S294S	VWA5A_uc001pzr.2_Silent_p.S294S|VWA5A_uc001pzs.2_Silent_p.S294S|VWA5A_uc010sae.1_Silent_p.S310S|VWA5A_uc001pzt.2_Silent_p.S294S	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	294	VWFA.									upper_aerodigestive_tract(1)|ovary(1)	2						GTATGCAGAGCCCCATGAGTA	0.463													7	21					0	0	0	0	T	123993788	T	T	123993788	2	4	105	1	0	0	0	0	0	0	0	1	17310	738	26	4		4	VWA5A	11	123993788	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	179837	123993788	11012728	63	19770											
SYT10	341359	broad.mit.edu	37	chr12	33559823	33559823	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttccccaatcatgtcatgTctagaaaatctgtcaaaatc	14	12	4	11	0	5	1	3	0	2	1	7	1	6	1	2	0	0	0	2	0	6	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr12:33559823T>C	uc001rll.1	-	3	1275	c.978A>G	c.(976-978)AGA>AGG	p.R326R	SYT10_uc009zju.1_Silent_p.R136R	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	326	Cytoplasmic (Potential).|C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TCATGTCATGTCTAGAAAATC	0.368													19	30					0	0	0	0	C	33559823	C	C	33559823	2	2	105	1	0	0	0	0	0	0	0	1	15532	1664	58	5		5	SYT10	12	33559823	Silent	SNP	T	TCGA-CQ-6223-01A-11D-1912-08		33559823	100292072	64	19771											
SFRS2IP	9169	broad.mit.edu	37	chr12	46326990	46326990	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgcctaatcaatgcactgaTttcactggcttctataaatt	11	15	5	10	0	3	1	2	1	1	0	3	1	3	1	1	1	2	2	1	1	5	6			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr12:46326990T>C	uc001rox.2	-	9	945	c.658A>G	c.(658-660)ATC>GTC	p.I220V	SFRS2IP_uc001roy.1_Missense_Mutation_p.I294V	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	220					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		AATGCACTGATTTCACTGGCT	0.308													12	42					0	0	0	0	C	46326990	C	C	46326990	3	2	105	1	0	0	0	0	1	0	0	0	14242	1493	52	5	3761	5	SFRS2IP	12	46326990	Missense_Mutation	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	12767167	46326990	87524905	65	19772											
ASB8	140461	broad.mit.edu	37	chr12	48543326	48543326	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catagctgcgggtctctggcCacctctcgtggcatggtgcc	4	10	13	14	2	2	0	0	0	2	0	4	0	2	0	3	4	3	2	3	4	1	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr12:48543326C>T	uc001rrh.2	-	4	859	c.690G>A	c.(688-690)GTG>GTA	p.V230V	ASB8_uc010slr.1_Silent_p.V226V	NM_024095	NP_077000	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box-containing 8	230					intracellular signal transduction	cytoplasm|nucleus				kidney(1)	1						GGTCTCTGGCCACCTCTCGTG	0.532													19	44					0	0	0	0	T	48543326	T	T	48543326	2	4	105	1	0	0	0	0	0	0	0	1	1031	581	21	4		4	ASB8	12	48543326	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	2216336	48543326	85308569	66	19773											
ACACB	32	broad.mit.edu	37	chr12	109634899	109634899	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caccggctgaatgatgggggGctcctgctctcctacaatgg	7	9	13	12	1	1	2	0	2	1	0	3	2	2	2	3	5	2	3	3	5	3	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr12:109634899G>A	uc001tob.2	+	17	2687	c.2568G>A	c.(2566-2568)GGG>GGA	p.G856G	ACACB_uc001toc.2_Silent_p.G856G	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	856					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	ATGATGGGGGGCTCCTGCTCT	0.587													20	31					0	0	0	0	A	109634899	A	A	109634899	2	1	105	1	0	0	0	0	0	0	0	1	107	1190	42	4		4	ACACB	12	109634899	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	61091573	109634899	24216996	67	19774											
RIMBP2	23504	broad.mit.edu	37	chr12	130912862	130912862	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctctctgtgtggtactcGtctccatggcaacagtgcgg	5	12	12	12	2	2	0	0	0	2	0	5	0	2	0	1	3	4	3	1	3	2	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr12:130912862G>A	uc001uil.2	-	12	2387	c.2223C>T	c.(2221-2223)GAC>GAT	p.D741D		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	741						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGTGGTACTCGTCTCCATGGC	0.587													28	54					0	0	0	0	A	130912862	A	A	130912862	2	1	105	1	0	0	0	0	0	0	0	1	13428	1136	40	1		1	RIMBP2	12	130912862	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	21277963	130912862	2939033	68	19775											
FREM2	341640	broad.mit.edu	37	chr13	39265021	39265021	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagagagacagttcttcccCattgtaatcattcccaccaa	12	11	5	13	0	3	2	2	0	1	2	5	3	5	2	4	0	0	2	4	0	2	5			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr13:39265021C>T	uc001uwv.2	+	1	3849	c.3540C>T	c.(3538-3540)CCC>CCT	p.P1180P		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1180	CSPG 8.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AGTTCTTCCCCATTGTAATCA	0.423													67	103					0	0	0	0	T	39265021	T	T	39265021	2	4	105	1	0	0	0	0	0	0	0	1	6079	581	21	4		4	FREM2	13	39265021	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08		39265021	75904857	69	19776											
PCDH20	64881	broad.mit.edu	37	chr13	61986231	61986231	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccatccatttcgtccagcGtcagcatctgttacactaat	10	12	5	14	2	2	0	1	0	1	0	5	0	4	0	3	0	3	2	3	0	2	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr13:61986231G>A	uc001vid.3	-	2	2365	c.2001C>T	c.(1999-2001)GAC>GAT	p.D667D	PCDH20_uc010thj.1_Silent_p.D667D	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	640	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TTCGTCCAGCGTCAGCATCTG	0.448													29	49					0	0	0	0	A	61986231	A	A	61986231	2	1	105	1	0	0	0	0	0	0	0	1	11569	1136	40	1		1	PCDH20	13	61986231	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	22721210	61986231	53183647	70	19777											
KLHL1	57626	broad.mit.edu	37	chr13	70456525	70456525	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgcatggaagatggtttCttcatcaggaacattgacat	13	12	9	7	0	3	2	2	1	1	1	3	4	3	4	0	3	2	2	0	3	3	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr13:70456525C>A	uc001vip.2	-	5	1911	c.1117G>T	c.(1117-1119)GAA>TAA	p.E373*	KLHL1_uc010thm.1_Nonsense_Mutation_p.E312*	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	373					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AAGATGGTTTCTTCATCAGGA	0.418													9	43					0.000274275	0.00104745	1	0	A	70456525	A	A	70456525	4	1	105	1	0	0	0	0	0	1	0	0	8404	922	32	2	1157	2	KLHL1	13	70456525	Nonsense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	8470294	70456525	44713353	71	19778											
TPPP2	122664	broad.mit.edu	37	chr14	21500154	21500154	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggcaagggcaagggcattgCgggacgggaagagatgactg	11	5	19	6	2	0	2	0	1	0	1	0	5	0	4	0	5	1	3	0	5	3	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr14:21500154C>A	uc001vzh.2	+	4	619	c.431C>A	c.(430-432)GCG>GAG	p.A144E	NDRG2_uc010tll.1_Intron	NM_173846	NP_776245	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family	144						cytoplasm					0	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		AAGGGCATTGCGGGACGGGAA	0.537													18	45					1.33834e-09	5.4393e-09	1	0	A	21500154	A	A	21500154	3	1	105	1	0	0	0	0	1	0	0	0	16481	768	27	3	441	3	TPPP2	14	21500154	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08		21500154	85849386	72	19779											
MUDENG	55745	broad.mit.edu	37	chr14	57741500	57741500	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaactgggacgtacaaaGgaaaaccacaagtttctatt	17	8	9	7	1	1	0	0	0	1	0	1	3	1	3	1	3	3	2	1	3	8	4			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr14:57741500G>A	uc001xcv.2	+	2	1040	c.613G>A	c.(613-615)GGA>AGA	p.G205R	MUDENG_uc001xcu.3_Missense_Mutation_p.G205R|MUDENG_uc010tri.1_Intron|MUDENG_uc010trj.1_Missense_Mutation_p.G102R	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	205	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1						GACGTACAAAGGAAAACCACA	0.373													13	37					0	0	0	0	A	57741500	A	A	57741500	3	1	105	1	0	0	0	0	1	0	0	0	10036	1001	35	4	619	4	MUDENG	14	57741500	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	36241346	57741500	49608040	73	19780											
TRIP11	9321	broad.mit.edu	37	chr14	92470836	92470836	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctcgaatgatacgtgataAattctgaatagtttctctaa	13	16	6	6	2	3	3	0	3	3	0	5	4	3	3	0	0	1	1	0	0	7	7			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr14:92470836A>C	uc001xzy.2	-	11	4272	c.3484T>G	c.(3484-3486)TTA>GTA	p.L1162V	TRIP11_uc010auf.1_Missense_Mutation_p.L898V	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1162	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		ATACGTGATAAATTCTGAATA	0.343			T	PDGFRB	AML								20	23					0	0	0	0	C	92470836	C	C	92470836	3	2	105	1	0	0	0	0	1	0	0	0	16622	11	1	5	2499	5	TRIP11	14	92470836	Missense_Mutation	SNP	A	TCGA-CQ-6223-01A-11D-1912-08	34729336	92470836	14878704	74	19781											
PPP1R13B	23368	broad.mit.edu	37	chr14	104206647	104206647	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgcgctttttcaggggccgGggcgcgttggccagcttcct	2	11	15	13	4	1	0	1	0	0	0	2	0	2	0	3	5	2	3	3	5	0	4			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr14:104206647G>C	uc001yof.1	-	12	2389	c.2106C>G	c.(2104-2106)CCC>CCG	p.P702P	PPP1R13B_uc010awv.1_RNA|PPP1R13B_uc001yog.1_Silent_p.P569P	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	702	Pro-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				TCAGGGGCCGGGGCGCGTTGG	0.667													40	92					0	0	0	0	C	104206647	C	C	104206647	2	2	105	1	0	0	0	0	0	0	0	1	12417	1219	43	4		4	PPP1R13B	14	104206647	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	11735811	104206647	3142893	75	19782											
HERC2	8924	broad.mit.edu	37	chr15	28483835	28483835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagtccagaagcctccatCtttattatggttctccaaat	11	13	5	12	0	2	1	0	0	2	1	5	1	4	1	4	1	1	1	4	1	4	4			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr15:28483835C>T	uc001zbj.2	-	24	3767	c.3661G>A	c.(3661-3663)GAT>AAT	p.D1221N		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1221	Cytochrome b5 heme-binding.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AAGCCTCCATCTTTATTATGG	0.378													22	36					0	0	0	0	T	28483835	T	T	28483835	3	4	105	1	0	0	0	0	1	0	0	0	7097	913	32	2	11123	2	HERC2	15	28483835	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08		28483835	74047557	76	19783											
SPTBN5	51332	broad.mit.edu	37	chr15	42150939	42150939	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggttcttctccctcagccacGcagccacctgggcacatggg	6	8	11	16	1	3	0	1	0	2	0	4	0	3	0	4	3	2	3	4	3	0	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr15:42150939G>A	uc001zos.2	-	49	8315	c.7982C>T	c.(7981-7983)GCG>GTG	p.A2661V		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2696	Spectrin 24.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CCTCAGCCACGCAGCCACCTG	0.622													6	7					0	0	0	0	A	42150939	A	A	42150939	3	1	105	1	0	0	0	0	1	0	0	0	15188	1087	38	1	3017	1	SPTBN5	15	42150939	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	13667104	42150939	60380453	77	19784											
PLA2G4F	255189	broad.mit.edu	37	chr15	42437772	42437772	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctcggggtcgctaccctcaCctgtgatattcacactgcct	6	11	9	15	2	2	1	2	1	0	0	4	1	2	1	3	2	2	2	3	2	2	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr15:42437772C>A	uc001zoz.2	-	16	1843	c.1780_splice	c.e16+1	p.D594_splice	PLA2G4F_uc010bcq.2_Intron|PLA2G4F_uc001zoy.2_Splice_Site_p.D226_splice|PLA2G4F_uc010bcr.2_Splice_Site_p.D345_splice|PLA2G4F_uc001zpa.2_Splice_Site_p.D345_splice|PLA2G4F_uc010bcs.2_Splice_Site_p.D381_splice	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF						phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GCTACCCTCACCTGTGATATT	0.602													17	102					5.35267e-07	2.11717e-06	1	0	A	42437772	A	A	42437772	5	1	105	1	0	0	0	0	0	0	1	0	12061	521	18	4	788	4	PLA2G4F	15	42437772	Splice_Site	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	286833	42437772	60093620	78	19785											
PTPN9	5780	broad.mit.edu	37	chr15	75798125	75798125	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccaccaactcttggatggTcatagcatggggacctggaa	10	9	12	10	0	2	0	1	0	1	0	3	3	3	3	3	5	2	1	3	5	3	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr15:75798125T>C	uc002bal.2	-	7	1367	c.859A>G	c.(859-861)ACC>GCC	p.T287A		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	287						cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						TCTTGGATGGTCATAGCATGG	0.502													3	65					0	0	0	0	C	75798125	C	C	75798125	3	2	105	1	0	0	0	0	1	0	0	0	12859	1667	58	5	950	5	PTPN9	15	75798125	Missense_Mutation	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	33360353	75798125	26733267	79	19786											
RASGRF1	5923	broad.mit.edu	37	chr15	79317766	79317766	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagggagagagaccccaggcGccccctggtgatcttgccct	7	7	13	14	1	1	3	0	1	1	2	1	5	1	3	5	3	1	0	5	3	1	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr15:79317766G>A	uc002beq.2	-	10	1807	c.1432C>T	c.(1432-1434)CGC>TGC	p.R478C	RASGRF1_uc002bep.2_Missense_Mutation_p.R478C|RASGRF1_uc010blm.1_Missense_Mutation_p.R400C|RASGRF1_uc002ber.3_Missense_Mutation_p.R478C	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	478	PH 2.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GACCCCAGGCGCCCCCTGGTG	0.557													25	43					0	0	0	0	A	79317766	A	A	79317766	3	1	105	1	0	0	0	0	1	0	0	0	13137	1087	38	1	2465	1	RASGRF1	15	79317766	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	3519641	79317766	23213626	80	19787											
AEN	64782	broad.mit.edu	37	chr15	89169644	89169644	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccccactgcccacccctttCggggcagcgacagcaactga	8	6	9	18	2	0	1	0	1	0	0	2	2	1	1	5	2	4	2	5	2	1	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr15:89169644C>T	uc002bmt.2	+	2	355	c.204C>T	c.(202-204)TTC>TTT	p.F68F	AEN_uc010bnl.2_Silent_p.F68F|AEN_uc010bnm.1_Silent_p.F68F	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	68					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						CCACCCCTTTCGGGGCAGCGA	0.652													7	18					0	0	0	0	T	89169644	T	T	89169644	2	4	105	1	0	0	0	0	0	0	0	1	351	883	31	1		1	AEN	15	89169644	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	9851878	89169644	13361748	81	19788											
CHD2	1106	broad.mit.edu	37	chr15	93563349	93563349	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgagcagcactggtacaagGaccaccattatggggaccgg	12	6	13	10	1	0	1	0	1	0	0	0	3	0	3	3	5	3	3	3	5	3	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr15:93563349G>T	uc002bsp.2	+	38	5589	c.5014G>T	c.(5014-5016)GAC>TAC	p.D1672Y	CHD2_uc002bso.1_Missense_Mutation_p.D1672Y	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1672					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CTGGTACAAGGACCACCATTA	0.527													11	27					1.05317e-09	4.31995e-09	1	0	T	93563349	T	T	93563349	3	4	105	1	0	0	0	0	1	0	0	0	3340	1174	41	2	5164	2	CHD2	15	93563349	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	4393705	93563349	8968043	82	19789											
NKD1	85407	broad.mit.edu	37	chr16	50667423	50667423	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctgcggtgtccccctccGcccacctggctgccagcccg	2	7	10	22	3	0	0	0	0	0	0	3	0	3	0	8	2	3	1	8	2	0	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr16:50667423G>A	uc002egg.1	+	10	1368	c.1144G>A	c.(1144-1146)GCC>ACC	p.A382T		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	382					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		GTCCCCCTCCGCCCACCTGGC	0.716													7	15					0	0	0	0	A	50667423	A	A	50667423	3	1	105	1	0	0	0	0	1	0	0	0	10495	1087	38	1	1182	1	NKD1	16	50667423	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08		50667423	39687330	83	19790											
CSNK2A2	1459	broad.mit.edu	37	chr16	58202514	58202514	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctggctgtaatggtacCtttttctgttggtgatctat	5	18	10	8	0	2	1	0	1	2	0	2	1	2	1	2	3	2	4	2	3	3	6			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr16:58202514C>T	uc002enc.2	-	6	655	c.513G>A	c.(511-513)AAG>AAA	p.K171K		NM_001896	NP_001887	P19784	CSK22_HUMAN	casein kinase 2, alpha prime polypeptide	171	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|nucleus	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						GTAATGGTACCTTTTTCTGTT	0.463													23	27					0	0	0	0	T	58202514	T	T	58202514	2	4	105	1	0	0	0	0	0	0	0	1	3975	695	24	4		4	CSNK2A2	16	58202514	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	7535091	58202514	32152239	84	19791											
BCMO1	53630	broad.mit.edu	37	chr16	81301576	81301576	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttctgctccatcccatcccGctccctgctctccccaagct	4	11	5	21	1	2	0	0	0	2	0	7	0	6	0	6	0	3	5	6	0	1	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr16:81301576G>A	uc002fgn.1	+	6	901	c.683G>A	c.(682-684)CGC>CAC	p.R228H	BCMO1_uc010vnp.1_Missense_Mutation_p.R159H	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	228					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						ATCCCATCCCGCTCCCTGCTC	0.527													27	48					0	0	0	0	A	81301576	A	A	81301576	3	1	105	1	0	0	0	0	1	0	0	0	1386	1087	38	1	705	1	BCMO1	16	81301576	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	23099062	81301576	9053177	85	19792											
ZC3H18	124245	broad.mit.edu	37	chr16	88643837	88643837	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgcgaggaggagggggaCgaaggggaggaagaccggac	11	1	21	8	3	0	1	0	0	0	1	0	9	0	7	2	8	1	0	2	8	2	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr16:88643837C>T	uc002fky.2	+	2	506	c.306C>T	c.(304-306)GAC>GAT	p.D102D	ZC3H18_uc010voy.1_Intron|ZC3H18_uc010voz.1_Silent_p.D102D|ZC3H18_uc010vpa.1_Silent_p.D102D	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	102						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		AGGAGGGGGACGAAGGGGAGG	0.617													11	17					0	0	0	0	T	88643837	T	T	88643837	2	4	105	1	0	0	0	0	0	0	0	1	17635	535	19	1		1	ZC3H18	16	88643837	Silent	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	7342261	88643837	1710916	86	19793											
TP53	7157	broad.mit.edu	37	chr17	7578454	7578454	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	actgcttgtagatggccatgGcgcggacgcgggtgccgggc	5	7	18	11	5	0	1	0	0	0	1	0	2	0	2	2	5	2	2	2	5	1	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr17:7578454G>A	uc002gim.2	-	5	670	c.476C>T	c.(475-477)GCC>GTC	p.A159V	TP53_uc002gig.1_Missense_Mutation_p.A159V|TP53_uc002gih.2_Missense_Mutation_p.A159V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A27V|TP53_uc010cng.1_Missense_Mutation_p.A27V|TP53_uc002gii.1_Missense_Mutation_p.A27V|TP53_uc010cnh.1_Missense_Mutation_p.A159V|TP53_uc010cni.1_Missense_Mutation_p.A159V|TP53_uc002gij.2_Missense_Mutation_p.A159V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A66V|TP53_uc002gio.2_Missense_Mutation_p.A27V|TP53_uc010vug.1_Missense_Mutation_p.A120V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	159	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> G (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(30)|p.A159P(13)|p.A159A(8)|p.A159T(7)|p.A159D(7)|p.0?(7)|p.A159fs*11(5)|p.A159S(4)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.A159fs*21(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGCCATGGCGCGGACGCG	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	22					0	0	0	0	A	7578454	A	A	7578454	3	1	105	1	0	0	0	0	1	0	0	0	16448	1203	42	4	822	4	TP53	17	7578454	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08		7578454	73616756	87	19794											
KRT33B	3884	broad.mit.edu	37	chr17	39521652	39521652	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagatgcccacctgcgtggCgaaccattgctccacttccc	7	10	8	16	2	0	1	0	0	0	1	2	2	2	1	5	1	4	1	5	1	2	3	rs148300082	byFrequency	TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr17:39521652C>T	uc002hwl.2	-	4	787	c.742G>A	c.(742-744)GCC>ACC	p.A248T		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	248	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				ACCTGCGTGGCGAACCATTGC	0.627													7	41					0	0	0	0	T	39521652	T	T	39521652	3	4	105	1	0	0	0	0	1	0	0	0	8509	768	27	1	488	1	KRT33B	17	39521652	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	31943198	39521652	41673558	88	19795											
SDK2	54549	broad.mit.edu	37	chr17	71395327	71395327	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcttccaccagccagcGggagatggaggttttcccat	7	9	13	12	1	0	1	0	0	0	1	2	3	2	2	4	4	2	2	4	4	0	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr17:71395327G>A	uc010dfm.2	-	22	3073	c.3073C>T	c.(3073-3075)CGC>TGC	p.R1025C	SDK2_uc002jjt.3_Missense_Mutation_p.R184C|SDK2_uc010dfn.2_Missense_Mutation_p.R704C	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1025	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						ACCAGCCAGCGGGAGATGGAG	0.632													15	24					0	0	0	0	A	71395327	A	A	71395327	3	1	105	1	0	0	0	0	1	0	0	0	14034	1116	39	1	3541	1	SDK2	17	71395327	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	31873675	71395327	9799883	89	19796											
RBBP8	5932	broad.mit.edu	37	chr18	20555133	20555133	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtgaatgaaaggaatactCtacaggaagaaaataaaaag	23	6	9	3	0	1	3	0	2	1	1	1	5	1	5	0	2	2	0	0	2	12	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr18:20555133C>G	uc002ktw.2	+	6	710	c.379C>G	c.(379-381)CTA>GTA	p.L127V	RBBP8_uc002kty.2_Missense_Mutation_p.L127V|RBBP8_uc002ktz.2_Missense_Mutation_p.L127V|RBBP8_uc002kua.2_Missense_Mutation_p.L127V|RBBP8_uc002ktx.1_Missense_Mutation_p.L127V	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	127	Potential.				cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			AAGGAATACTCTACAGGAAGA	0.269								Direct_reversal_of_damage|Homologous_recombination					5	11					0	0	0	0	G	20555133	G	G	20555133	3	3	105	1	0	0	0	0	1	0	0	0	13170	912	32	2	397	2	RBBP8	18	20555133	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08		20555133	57522115	90	19797											
PPAN-P2RY11	692312	broad.mit.edu	37	chr19	10225151	10225152	+	Frame_Shift_Del	DEL	AT	-	-																															gctgcccgagctttgcagacAtagcccaggccacagcagcc																								rs151191595		TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:10225151_10225152delAT	uc002mna.2	+	13	2122_2123	c.2122_2123delAT	c.(2122-2124)ATAfs	p.I708fs	PPAN-P2RY11_uc010xla.1_3'UTR|P2RY11_uc002mnc.2_Frame_Shift_Del_p.I288fs	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	Error:Variant_position_missing_in_Q9NQ55_after_alignment					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			CTTTGCAGACATAGCCCAGGCC	0.658													---	---	---								-	10225152	-	-	10225151	7	5	105	1	0	1	0	1	0	0	0	0	12344	217	8	0		0	PPAN-P2RY11	19	10225151	Frame_Shift_Del	DEL	AT	TCGA-CQ-6223-01A-11D-1912-08		10225151	48903832	91	19798											
PDE4C	5143	broad.mit.edu	37	chr19	18329002	18329002	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaccccaggatggtccacGtcgtggatggcgcttgcaaa	9	7	14	11	3	0	1	0	0	0	1	2	4	1	3	3	4	1	2	3	4	1	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:18329002G>A	uc010xqc.1	-	11	1767	c.1287C>T	c.(1285-1287)GAC>GAT	p.D429D	PDE4C_uc002nik.3_Silent_p.D429D|PDE4C_uc002nil.3_Silent_p.D429D|PDE4C_uc002nif.3_Silent_p.D198D|PDE4C_uc002nig.3_Silent_p.D144D|PDE4C_uc002nih.3_Silent_p.D199D|PDE4C_uc010ebk.2_Silent_p.D323D|PDE4C_uc002nii.3_Silent_p.D397D|PDE4C_uc010ebl.2_Silent_p.D143D|PDE4C_uc010xqd.1_Silent_p.D198D	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	429		Divalent metal cation 1.|cAMP (By similarity).|Divalent metal cation 2.			signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	GATGGTCCACGTCGTGGATGG	0.592													20	41					0	0	0	0	A	18329002	A	A	18329002	2	1	105	1	0	0	0	0	0	0	0	1	11695	1136	40	1		1	PDE4C	19	18329002	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	8103851	18329002	40799981	92	19799											
MLL4	9757	broad.mit.edu	37	chr19	36217142	36217142	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccctgctcccccagatctgTtcagcctgtgtgcgctgtaa	5	11	10	15	1	2	1	1	0	1	1	3	1	3	1	4	0	3	4	4	0	1	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:36217142T>C	uc010eei.2	+	15	3891	c.3891T>C	c.(3889-3891)TGT>TGC	p.C1297C		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1297	PHD-type 2.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCAGATCTGTTCAGCCTGTG	0.597													5	32					0	0	0	0	C	36217142	C	C	36217142	2	2	105	1	0	0	0	0	0	0	0	1	9676	1731	60	5		5	MLL4	19	36217142	Silent	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	17888140	36217142	22911841	93	19800											
ZNF829	374899	broad.mit.edu	37	chr19	37382576	37382576	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtttttcatctgtatggaTtctctgatgttgaataagtt	8	20	9	4	0	3	2	1	2	2	0	4	3	3	3	0	2	0	4	0	2	3	7			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:37382576T>C	uc002ofa.1	-	6	1479	c.1117A>G	c.(1117-1119)ATC>GTC	p.I373V	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	373	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTGTATGGATTCTCTGATGT	0.373													9	19					0	0	0	0	C	37382576	C	C	37382576	3	2	105	1	0	0	0	0	1	0	0	0	18249	1493	52	5	185	5	ZNF829	19	37382576	Missense_Mutation	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	1165434	37382576	21746407	94	19801											
CEACAM5	1048	broad.mit.edu	37	chr19	42224848	42224848	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctttgttccagatgggcCggacacccccatcatttccc	6	12	7	16	1	2	1	1	0	1	1	5	2	4	2	5	2	0	1	5	2	0	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:42224848C>A	uc002ork.2	+	8	1899	c.1778C>A	c.(1777-1779)CCG>CAG	p.P593Q	CEACAM5_uc002orj.1_Missense_Mutation_p.P592Q|CEACAM5_uc002orl.2_Missense_Mutation_p.P593Q	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	593	Ig-like 6.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CCAGATGGGCCGGACACCCCC	0.552													33	141					2.80507e-11	1.17231e-10	1	0	A	42224848	A	A	42224848	3	1	105	1	0	0	0	0	1	0	0	0	3210	652	23	3	1808	3	CEACAM5	19	42224848	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	4842272	42224848	16904135	95	19802											
SULT2A1	6822	broad.mit.edu	37	chr19	48374806	48374806	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggccactgtgaagtgatttTtccagtccccagatacacct	9	11	9	12	0	0	3	0	2	0	1	2	3	2	3	5	1	1	0	5	1	2	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:48374806T>G	uc002phr.2	-	6	904	c.764A>C	c.(763-765)AAA>ACA	p.K255T		NM_003167	NP_003158	Q06520	ST2A1_HUMAN	bile-salt sulfotransferase 2A1	255					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			ovary(1)|pancreas(1)	2		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		GAAGTGATTTTTCCAGTCCCC	0.478													3	58					0	0	0	0	G	48374806	G	G	48374806	3	3	105	1	0	0	0	0	1	0	0	0	15447	1841	64	5	97	5	SULT2A1	19	48374806	Missense_Mutation	SNP	T	TCGA-CQ-6223-01A-11D-1912-08	6149958	48374806	10754177	96	19803											
MYBPC2	4606	broad.mit.edu	37	chr19	50958379	50958379	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctccagggtacctcgtagagCggaagaagaagggctctcag	11	6	14	10	2	1	3	1	0	1	3	4	4	2	4	2	3	2	3	2	3	5	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:50958379C>T	uc002psf.2	+	19	2080	c.2029C>T	c.(2029-2031)CGG>TGG	p.R677W		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	677	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CCTCGTAGAGCGGAAGAAGAA	0.572													11	27					0	0	0	0	T	50958379	T	T	50958379	3	4	105	1	0	0	0	0	1	0	0	0	10065	759	27	1	2103	1	MYBPC2	19	50958379	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	2583573	50958379	8170604	97	19804											
TMEM150B	284417	broad.mit.edu	37	chr19	55824407	55824407	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagacgctacgcagcgagcaGgcgtggaggacgatcactgc	10	4	16	11	5	1	1	1	0	0	1	1	6	1	3	0	3	4	3	0	3	1	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:55824407G>T	uc010esw.1	-	8	695	c.522C>A	c.(520-522)GCC>GCA	p.A174A	TMEM150B_uc010yfu.1_Silent_p.A174A|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	174	Helical; (Potential).					integral to membrane					0						GCAGCGAGCAGGCGTGGAGGA	0.677													8	9					5.18039e-06	2.01308e-05	1	0	T	55824407	T	T	55824407	2	4	105	1	0	0	0	0	0	0	0	1	16134	987	35	4		4	TMEM150B	19	55824407	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	4866028	55824407	3304576	98	19805			1	24		2	2	13	G		4.14764e-05
TMEM150B	284417	broad.mit.edu	37	chr19	55824419	55824419	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgagcaggcgtggaggacGatcactgccccagggtcaag	10	4	16	11	3	2	0	2	0	0	0	2	4	2	2	2	4	3	1	2	4	1	0			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:55824419G>A	uc010esw.1	-	8	683	c.510C>T	c.(508-510)ATC>ATT	p.I170I	TMEM150B_uc010yfu.1_Silent_p.I170I|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	170	Helical; (Potential).					integral to membrane					0						CGTGGAGGACGATCACTGCCC	0.677													6	7					0	0	0	0	A	55824419	A	A	55824419	2	1	105	1	0	0	0	0	0	0	0	1	16134	1048	37	1		1	TMEM150B	19	55824419	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	12	55824419	3304564	99	19806			1	24		2	2	13	G		4.14764e-05
ZNF835	90485	broad.mit.edu	37	chr19	57175695	57175695	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccggtgctgggtcaggtgcGcgatctgcgcgaaggccttg	4	8	18	11	5	2	0	1	0	1	0	2	2	2	0	2	4	3	1	2	4	1	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:57175695G>A	uc010ygo.1	-	2	938	c.938C>T	c.(937-939)GCG>GTG	p.A313V	ZNF835_uc010ygn.1_Missense_Mutation_p.A291V	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GGTCAGGTGCGCGATCTGCGC	0.697													6	9					0	0	0	0	A	57175695	A	A	57175695	3	1	105	1	0	0	0	0	1	0	0	0	18253	1087	38	1	743	1	ZNF835	19	57175695	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	1351276	57175695	1953288	100	19807											
USP29	57663	broad.mit.edu	37	chr19	57640091	57640091	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccaaatttggagccagaaGactgggatgactaagctgaa	15	8	11	7	0	0	4	0	2	0	2	1	6	1	6	2	2	2	1	2	2	4	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr19:57640091G>T	uc002qny.2	+	4	404	c.48G>T	c.(46-48)AAG>AAT	p.K16N		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	16					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGAGCCAGAAGACTGGGATGA	0.348													9	21					7.48243e-07	2.93338e-06	1	0	T	57640091	T	T	57640091	3	4	105	1	0	0	0	0	1	0	0	0	17127	933	33	2	50	2	USP29	19	57640091	Missense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	464396	57640091	1488892	101	19808											
C20orf12	55184	broad.mit.edu	37	chr20	18433269	18433269	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaagttacctgggactggCgggtgggtggtctagaacct	8	10	16	7	1	1	2	0	0	1	2	1	3	1	3	2	5	2	1	2	5	5	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr20:18433269C>T	uc010zsa.1	-	6	799	c.590G>A	c.(589-591)CGC>CAC	p.R197H	C20orf12_uc002wqr.3_RNA|C20orf12_uc002wqs.3_Missense_Mutation_p.A28T|C20orf12_uc002wqq.3_Missense_Mutation_p.R178H|C20orf12_uc002wqu.1_Intron|C20orf12_uc010gct.1_Intron	NM_001099407	NP_001092877	Q9NVP4	CT012_HUMAN	hypothetical protein LOC55184	Error:Variant_position_missing_in_Q9NVP4_after_alignment						intracellular	zinc ion binding			ovary(1)	1		Myeloproliferative disorder(85;0.0122)				CTGGGACTGGCGGGTGGGTGG	0.433													3	5					0	0	0	0	T	18433269	T	T	18433269	3	4	105	1	0	0	0	0	1	0	0	0	2095	768	27	1	1789	1	C20orf12	20	18433269	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08		18433269	44592251	102	19809											
SPATA2	9825	broad.mit.edu	37	chr20	48523004	48523004	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggcttgtagtagtccttggCcgcccgctcgctggccgact	3	10	14	14	4	0	0	0	0	0	0	2	1	1	0	4	3	0	5	4	3	2	4			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chr20:48523004C>T	uc010gie.2	-	3	1065	c.715G>A	c.(715-717)GCC>ACC	p.A239T	SPATA2_uc002xuw.2_Missense_Mutation_p.A239T|SPATA2_uc010zyn.1_Missense_Mutation_p.A102T	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	239					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TAGTCCTTGGCCGCCCGCTCG	0.677													17	35					0	0	0	0	T	48523004	T	T	48523004	3	4	105	1	0	0	0	0	1	0	0	0	15071	739	26	4	851	4	SPATA2	20	48523004	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	30089735	48523004	14502516	103	19810											
MXRA5	25878	broad.mit.edu	37	chrX	3228388	3228388	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgtgtggccagcggcattgCgggccacgcagcggtaggcc	5	5	17	14	5	0	0	0	0	0	0	0	0	0	0	4	5	3	3	4	5	1	2			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chrX:3228388C>A	uc004crg.3	-	7	8013	c.7856G>T	c.(7855-7857)CGC>CTC	p.R2619L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2619	Ig-like C2-type 10.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AGCGGCATTGCGGGCCACGCA	0.597													22	6					2.98393e-07	1.19088e-06	1	0	A	3228388	A	A	3228388	3	1	105	1	0	0	0	0	1	0	0	0	10056	768	27	3	634	3	MXRA5	23	3228388	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08		3228388	152042172	104	19811											
GRPR	2925	broad.mit.edu	37	chrX	16168686	16168686	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctacgtcattccactgtcGatcatctctgtttactacta	8	17	4	12	2	4	0	2	0	2	0	7	1	5	0	1	0	3	1	1	0	4	7			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chrX:16168686G>A	uc004cxj.2	+	2	1325	c.672G>A	c.(670-672)TCG>TCA	p.S224S		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	224	Helical; Name=5; (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity	p.S224S(1)		ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					TTCCACTGTCGATCATCTCTG	0.438													5	48					0	0	0	0	A	16168686	A	A	16168686	2	1	105	1	0	0	0	0	0	0	0	1	6847	1045	37	1		1	GRPR	23	16168686	Silent	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	12940298	16168686	139101874	105	19812											
SLC25A14	9016	broad.mit.edu	37	chrX	129479183	129479183	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtaccactgtaagtcatGagatgtctggtctgaattgg	12	12	11	6	0	3	2	1	2	2	1	3	3	3	2	1	2	1	2	1	2	4	3			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chrX:129479183G>T	uc004evn.1	+	3	316	c.103G>T	c.(103-105)GAG>TAG	p.E35*	SLC25A14_uc011mut.1_5'UTR|SLC25A14_uc011muu.1_Nonsense_Mutation_p.E35*|SLC25A14_uc010nrg.2_Nonsense_Mutation_p.E32*|SLC25A14_uc004evo.1_5'UTR|SLC25A14_uc004evp.1_Nonsense_Mutation_p.E35*|SLC25A14_uc004evq.1_Nonsense_Mutation_p.E32*|SLC25A14_uc004evr.1_Nonsense_Mutation_p.E32*	NM_003951	NP_003942	O95258	UCP5_HUMAN	solute carrier family 25, member 14 isoform	35					aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			ovary(1)	1						TGTAAGTCATGAGATGTCTGG	0.388													35	19					1.26612e-14	5.49892e-14	1	0	T	129479183	T	T	129479183	4	4	105	1	0	0	0	0	0	1	0	0	14540	1291	45	2	109	2	SLC25A14	23	129479183	Nonsense_Mutation	SNP	G	TCGA-CQ-6223-01A-11D-1912-08	113310497	129479183	25791377	106	19813											
FGF13	2258	broad.mit.edu	37	chrX	137715118	137715118	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgggagaactccgtgagatCgtgcagtgatggctccttgt	7	11	14	9	3	0	3	0	2	0	2	4	5	2	3	2	2	2	2	2	2	1	1			TCGA-CQ-6223-01A-11D-1912-08	TCGA-CQ-6223-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	be7cb5b4-1d09-479c-8bf2-a9e7abde575f	2e4128e2-7d9d-4ef1-a2ad-d8eb0a570045	g.chrX:137715118C>T	uc004fam.2	-	5	1293	c.631G>A	c.(631-633)GAT>AAT	p.D211N	FGF13_uc004fan.2_Missense_Mutation_p.D158N|FGF13_uc011mwi.1_Missense_Mutation_p.D192N|FGF13_uc004faq.2_Missense_Mutation_p.D221N|FGF13_uc004far.2_Missense_Mutation_p.D192N|FGF13_uc011mwj.1_Missense_Mutation_p.D221N|FGF13_uc011mwk.1_Missense_Mutation_p.D165N	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	211					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TCCGTGAGATCGTGCAGTGAT	0.468													40	14					0	0	0	0	T	137715118	T	T	137715118	3	4	105	1	0	0	0	0	1	0	0	0	5874	884	31	1	110	1	FGF13	23	137715118	Missense_Mutation	SNP	C	TCGA-CQ-6223-01A-11D-1912-08	8235935	137715118	17555442	107	19814											
SFRS4	6429	broad.mit.edu	37	chr1	29508253	29508253	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagctcaggcggccgatgtaCacccgcggcatcccggcaac	8	5	12	16	5	1	0	1	0	0	0	2	1	2	0	3	4	3	4	3	4	3	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:29508253C>T	uc001bro.2	-	1	385	c.12G>A	c.(10-12)GTG>GTA	p.V4V	SFRS4_uc010ofy.1_Silent_p.V4V|SFRS4_uc009vtp.2_RNA	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	4	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		GGCCGATGTACACCCGCGGCA	0.612													5	36					0	0	0	0	T	29508253	T	T	29508253	2	4	106	1	0	0	0	0	0	0	0	1	14244	465	17	4		4	SFRS4	1	29508253	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08		29508253	219742368	1	19815											
GRIK3	2899	broad.mit.edu	37	chr1	37346378	37346378	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagcgggtggtgcttccaaCgcagctggatgtggggcacc	6	7	16	12	2	0	0	0	0	0	0	1	1	1	1	3	5	4	4	3	5	1	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:37346378C>T	uc001caz.2	-	3	542	c.407G>A	c.(406-408)CGT>CAT	p.R136H	GRIK3_uc001cba.1_Missense_Mutation_p.R136H	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	136	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GTGCTTCCAACGCAGCTGGAT	0.622													4	84					0	0	0	0	T	37346378	T	T	37346378	3	4	106	1	0	0	0	0	1	0	0	0	6814	536	19	1	2408	1	GRIK3	1	37346378	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	7838125	37346378	211904243	2	19816											
TCTEX1D4	343521	broad.mit.edu	37	chr1	45271807	45271807	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacgccctggcccgcgcgCggccccagcaccacactgca	7	3	11	20	5	0	1	0	1	0	0	0	1	0	1	5	2	3	2	5	2	1	0			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:45271807C>T	uc001cmp.2	-	2	1043	c.534G>A	c.(532-534)CCG>CCA	p.P178P	BTBD19_uc010old.1_5'Flank|BTBD19_uc010ole.1_5'Flank	NM_001013632	NP_001013654	Q5JR98	TC1D4_HUMAN	Tctex1 domain containing 4	178										pancreas(1)	1	Acute lymphoblastic leukemia(166;0.155)					GGCCCGCGCGCGGCCCCAGCA	0.716													6	6					0	0	0	0	T	45271807	T	T	45271807	2	4	106	1	0	0	0	0	0	0	0	1	15787	755	27	1		1	TCTEX1D4	1	45271807	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	7925429	45271807	203978814	3	19817											
AKNAD1	254268	broad.mit.edu	37	chr1	109369904	109369904	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agttgatccttccgtggcccTttttctccacgttttgcttc	3	18	7	13	2	1	1	0	1	1	0	5	1	3	1	4	1	1	3	4	1	0	7			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:109369904T>C	uc001dwa.2	-	11	2128	c.1859A>G	c.(1858-1860)AAG>AGG	p.K620R	AKNAD1_uc010ovb.1_Missense_Mutation_p.K327R|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	620										ovary(3)	3						TCCGTGGCCCTTTTTCTCCAC	0.413													3	185					0	0	0	0	C	109369904	C	C	109369904	3	2	106	1	0	0	0	0	1	0	0	0	464	1609	56	5	675	5	AKNAD1	1	109369904	Missense_Mutation	SNP	T	TCGA-CQ-6224-01A-11D-1912-08	64098097	109369904	139880717	4	19818											
FCRL4	83417	broad.mit.edu	37	chr1	157551405	157551405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctccagtggctcccgcggCgacaaggccatctctgttgc	5	8	11	17	3	1	0	0	0	1	0	4	1	3	0	4	3	1	2	4	3	1	1	rs143188744	byFrequency	TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:157551405C>T	uc001fqw.2	-	7	1301	c.1165G>A	c.(1165-1167)GCC>ACC	p.A389T	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	389	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GCTCCCGCGGCGACAAGGCCA	0.572													5	21					0	0	0	0	T	157551405	T	T	157551405	3	4	106	1	0	0	0	0	1	0	0	0	5829	768	27	1	406	1	FCRL4	1	157551405	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	48181501	157551405	91699216	5	19819											
HMCN1	83872	broad.mit.edu	37	chr1	186106021	186106021	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgaatttgaatgtgttgctCgaaacttaatgggttctgtc	9	16	10	6	1	1	2	0	2	1	0	3	3	1	2	0	1	2	3	0	1	4	4			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:186106021C>T	uc001grq.1	+	87	13763	c.13534C>T	c.(13534-13536)CGA>TGA	p.R4512*	HMCN1_uc001grs.1_Nonsense_Mutation_p.R81*	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4512	Ig-like C2-type 44.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATGTGTTGCTCGAAACTTAAT	0.428													29	71					0	0	0	0	T	186106021	T	T	186106021	4	4	106	1	0	0	0	0	0	1	0	0	7259	876	31	1	13880	1	HMCN1	1	186106021	Nonsense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	28554616	186106021	63144600	6	19820											
DEGS1	8560	broad.mit.edu	37	chr1	224377307	224377307	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagagataaagtccttgatGaaacctgatcccaatttgat	14	11	7	9	0	0	5	0	4	0	1	2	6	2	5	4	0	1	0	4	0	4	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:224377307G>A	uc001hoj.2	+	2	222	c.111G>A	c.(109-111)ATG>ATA	p.M37I	DEGS1_uc001hoi.2_Missense_Mutation_p.M16I	NM_144780	NP_659004	O15121	DEGS1_HUMAN	degenerative spermatocyte homolog 1, lipid	37					sphingolipid metabolic process|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	electron carrier activity|protein binding|sphingolipid delta-4 desaturase activity				0	Breast(184;0.193)			GBM - Glioblastoma multiforme(131;0.00643)		AGTCCTTGATGAAACCTGATC	0.313													12	63					0	0	0	0	A	224377307	A	A	224377307	3	1	106	1	0	0	0	0	1	0	0	0	4444	1290	45	2	117	2	DEGS1	1	224377307	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	38271286	224377307	24873314	7	19821											
OBSCN	84033	broad.mit.edu	37	chr1	228468013	228468013	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacgggatgcccctgtacaaCgacagcttccatgagatctc	11	8	9	13	2	1	1	0	1	1	1	3	4	2	2	3	1	5	2	3	1	3	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr1:228468013C>T	uc009xez.1	+	29	7841	c.7797C>T	c.(7795-7797)AAC>AAT	p.N2599N	OBSCN_uc001hsn.2_Silent_p.N2599N|OBSCN_uc001hsp.1_Silent_p.N298N|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2599	Ig-like 25.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCCTGTACAACGACAGCTTCC	0.627													3	16					0	0	0	0	T	228468013	T	T	228468013	2	4	106	1	0	0	0	0	0	0	0	1	10866	535	19	1		1	OBSCN	1	228468013	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	4090706	228468013	20782608	8	19822											
CCDC85A	114800	broad.mit.edu	37	chr2	56420192	56420192	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagcaccacaaacccttgtGcaagggcagccccgaacagc	12	3	11	15	1	0	0	0	0	0	0	0	2	0	1	4	2	6	3	4	2	3	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:56420192G>T	uc002rzn.2	+	2	1359	c.857G>T	c.(856-858)TGC>TTC	p.C286F		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	286	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AAACCCTTGTGCAAGGGCAGC	0.632													16	84					4.14922e-12	4.60563e-12	1	0	T	56420192	T	T	56420192	3	4	106	1	0	0	0	0	1	0	0	0	2872	1319	46	4	863	4	CCDC85A	2	56420192	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08		56420192	186779181	9	19823											
TTN	7273	broad.mit.edu	37	chr2	179433038	179433038	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctagcaacagtagcagaaaCaacatcccatactgtggtgg	14	8	9	10	0	1	1	0	0	1	1	2	1	2	1	1	2	6	3	1	2	6	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:179433038C>T	uc010zfg.1	-	275	70341	c.70117G>A	c.(70117-70119)GTT>ATT	p.V23373I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V17068I|TTN_uc010zfi.1_Missense_Mutation_p.V17001I|TTN_uc010zfj.1_Missense_Mutation_p.V16876I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24300							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAGCAGAAACAACATCCCAT	0.383													18	58					0	0	0	0	T	179433038	T	T	179433038	3	4	106	1	0	0	0	0	1	0	0	0	16803	478	17	4	30306	4	TTN	2	179433038	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	123012846	179433038	63766335	10	19824											
TTN	7273	broad.mit.edu	37	chr2	179587178	179587178	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagcacacttggatgggtgCagagccatttaatcgacaag	12	8	11	10	1	0	1	0	0	0	1	1	3	0	2	2	2	3	2	2	2	2	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:179587178C>A	uc010zfg.1	-	74	18828	c.18604G>T	c.(18604-18606)GCA>TCA	p.A6202S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A2863S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7129							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGATGGGTGCAGAGCCATTT	0.393													14	69					1.5842e-08	1.72398e-08	1	0	A	179587178	A	A	179587178	3	1	106	1	0	0	0	0	1	0	0	0	16803	710	25	4	82337	4	TTN	2	179587178	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	154140	179587178	63612195	11	19825											
NEUROD1	4760	broad.mit.edu	37	chr2	182542610	182542610	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atattgtctatggggatctcGcagcgaggggcagcggtgcc	7	9	16	9	3	2	0	0	0	2	0	3	2	2	1	1	5	3	2	1	5	2	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:182542610G>A	uc002uof.2	-	2	1214	c.978C>T	c.(976-978)TGC>TGT	p.C326C	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	326					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TGGGGATCTCGCAGCGAGGGG	0.502													10	102					0	0	0	0	A	182542610	A	A	182542610	2	1	106	1	0	0	0	0	0	0	0	1	10402	1079	38	1		1	NEUROD1	2	182542610	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	2955432	182542610	60656763	12	19826											
SPAG16	79582	broad.mit.edu	37	chr2	214878680	214878680	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttctctctttatagtgaaaGatgcagatgtactttgtatg	10	18	8	5	0	2	3	0	1	2	2	3	3	2	3	0	0	2	3	0	0	5	7			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:214878680G>A	uc002veq.2	+	13	1498	c.1406G>A	c.(1405-1407)AGA>AAA	p.R469K	SPAG16_uc010fuz.1_Missense_Mutation_p.R320K|SPAG16_uc002ver.2_Missense_Mutation_p.R415K|SPAG16_uc010zjk.1_Missense_Mutation_p.R375K	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	469	WD 3.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TATAGTGAAAGATGCAGATGT	0.338													10	73					0	0	0	0	A	214878680	A	A	214878680	3	1	106	1	0	0	0	0	1	0	0	0	15044	942	33	2	1472	2	SPAG16	2	214878680	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	32336070	214878680	28320693	13	19827											
UGT1A1	54658	broad.mit.edu	37	chr2	234669125	234669125	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtcctagcacctgacgcCtcgttgtacatcagagacgg	8	10	11	12	3	1	2	1	1	0	1	3	3	2	2	3	1	2	4	3	1	2	4			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr2:234669125C>T	uc002vvb.2	+	1	207	c.192C>T	c.(190-192)GCC>GCT	p.A64A	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Silent_p.A64A	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	64					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CACCTGACGCCTCGTTGTACA	0.522													11	88					0	0	0	0	T	234669125	T	T	234669125	2	4	106	1	0	0	0	0	0	0	0	1	17012	668	24	4		4	UGT1A1	2	234669125	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	19790445	234669125	8530248	14	19828											
TOP2B	7155	broad.mit.edu	37	chr3	25639860	25639860	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agactctgcaaaatattttaCttctttcctagcccgaccgg	10	13	6	12	2	2	1	0	0	2	1	3	2	3	1	3	1	3	1	3	1	5	6			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr3:25639860C>T	uc003cdj.2	-	36	4804	c.4804G>A	c.(4804-4806)GTA>ATA	p.V1602I	TOP2B_uc011awm.1_Missense_Mutation_p.V459I|TOP2B_uc010hff.1_Missense_Mutation_p.V468I	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	1607					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AAATATTTTACTTCTTTCCTA	0.403													11	43					0	0	0	0	T	25639860	T	T	25639860	3	4	106	1	0	0	0	0	1	0	0	0	16433	565	20	4	65	4	TOP2B	3	25639860	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08		25639860	172382570	15	19829											
SLC7A14	57709	broad.mit.edu	37	chr3	170198808	170198808	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaagacacagacagagacCaaggtgtaggccaggagcgt	15	3	14	9	1	0	3	0	0	0	3	0	5	0	4	2	3	2	2	2	3	3	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr3:170198808C>T	uc003fgz.2	-	7	1579	c.1263G>A	c.(1261-1263)TTG>TTA	p.L421L	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	421	Helical; (Potential).					integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AGACAGAGACCAAGGTGTAGG	0.532													14	91					0	0	0	0	T	170198808	T	T	170198808	2	4	106	1	0	0	0	0	0	0	0	1	14760	593	21	4		4	SLC7A14	3	170198808	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	144558948	170198808	27823622	16	19830											
INTS12	57117	broad.mit.edu	37	chr4	106621141	106621141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caaaaaaatgggatcaagttCcaagttcacagtagcagcca	17	7	8	9	0	2	0	2	0	0	0	3	1	3	1	2	1	2	4	2	1	6	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr4:106621141C>T	uc003hxw.2	-	3	280	c.22G>A	c.(22-24)GAA>AAA	p.E8K	INTS12_uc010ilr.2_Missense_Mutation_p.E8K	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	8					snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		GGATCAAGTTCCAAGTTCACA	0.358													37	85					0	0	0	0	T	106621141	T	T	106621141	3	4	106	1	0	0	0	0	1	0	0	0	7816	864	30	2	1390	2	INTS12	4	106621141	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08		106621141	84533135	17	19831											
ENPP6	133121	broad.mit.edu	37	chr4	185012424	185012424	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccttcagcatgcacatcAccctggaccaggatccgttg	8	8	10	15	1	2	0	2	0	0	0	3	2	3	2	4	3	2	3	4	3	0	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr4:185012424A>C	uc003iwc.2	-	8	1371	c.1229T>G	c.(1228-1230)GTG>GGG	p.V410G		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	410	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		CATGCACATCACCCTGGACCA	0.587													6	76					0	0	0	0	C	185012424	C	C	185012424	3	2	106	1	0	0	0	0	1	0	0	0	5158	159	6	5	97	5	ENPP6	4	185012424	Missense_Mutation	SNP	A	TCGA-CQ-6224-01A-11D-1912-08	78391283	185012424	6141852	18	19832											
KLKB1	3818	broad.mit.edu	37	chr4	187172684	187172684	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggagttgactttggaggAgaagaattgaatgtgacttt	11	12	14	4	1	0	5	0	3	0	2	0	8	0	7	1	3	0	1	1	3	3	4			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr4:187172684A>G	uc003iyy.2	+	9	983	c.912A>G	c.(910-912)GGA>GGG	p.G304G	KLKB1_uc011clc.1_Silent_p.G102G|KLKB1_uc011cld.1_Silent_p.G266G	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	304	Apple 4.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		ACTTTGGAGGAGAAGAATTGA	0.373													3	73					0	0	0	0	G	187172684	G	G	187172684	2	3	106	1	0	0	0	0	0	0	0	1	8451	291	11	5		5	KLKB1	4	187172684	Silent	SNP	A	TCGA-CQ-6224-01A-11D-1912-08	2160260	187172684	3981592	19	19833											
RASA1	5921	broad.mit.edu	37	chr5	86674234	86674234	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaagccactaccctatttcGagccacaacacttgcaagca	13	8	6	14	1	0	1	0	1	0	0	1	2	0	1	3	0	6	2	3	0	5	4			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr5:86674234G>A	uc003kiw.2	+	18	2484	c.2366G>A	c.(2365-2367)CGA>CAA	p.R789Q	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.R612Q|RASA1_uc011ctv.1_Missense_Mutation_p.R622Q|RASA1_uc011ctw.1_Missense_Mutation_p.R623Q|RASA1_uc010jaw.2_Missense_Mutation_p.R611Q	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	789	Ras-GAP.			R -> A (in Ref. 4; AA sequence).	cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		ACCCTATTTCGAGCCACAACA	0.353													13	32					0	0	0	0	A	86674234	A	A	86674234	3	1	106	1	0	0	0	0	1	0	0	0	13125	1058	37	1	2448	1	RASA1	5	86674234	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08		86674234	94241026	20	19834											
GPR98	84059	broad.mit.edu	37	chr5	90079036	90079036	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatctctcagagctcctctGccagtcccggaggtgttgat	6	12	10	13	1	4	2	2	1	2	1	7	3	6	3	3	2	2	2	3	2	0	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr5:90079036G>A	uc003kju.2	+	66	13423	c.13327G>A	c.(13327-13329)GCC>ACC	p.A4443T	GPR98_uc003kjt.2_Missense_Mutation_p.A2149T|GPR98_uc003kjw.2_Missense_Mutation_p.A104T	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4443	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GAGCTCCTCTGCCAGTCCCGG	0.443													27	113					0	0	0	0	A	90079036	A	A	90079036	3	1	106	1	0	0	0	0	1	0	0	0	6760	1319	46	4	13589	4	GPR98	5	90079036	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	3404802	90079036	90836224	21	19835											
PSD2	84249	broad.mit.edu	37	chr5	139201499	139201499	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acattcttgaaggccttcccGctgatgggggagacacaaga	11	8	12	10	1	1	4	0	2	1	2	2	5	2	4	2	3	0	1	2	3	2	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr5:139201499G>A	uc003leu.1	+	6	1324	c.1119G>A	c.(1117-1119)CCG>CCA	p.P373P		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	373	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCCTTCCCGCTGATGGGGG	0.587													7	64					0	0	0	0	A	139201499	A	A	139201499	2	1	106	1	0	0	0	0	0	0	0	1	12709	1074	38	1		1	PSD2	5	139201499	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	49122463	139201499	41713761	22	19836											
ABLIM3	22885	broad.mit.edu	37	chr5	148590346	148590346	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtttggcattaaatgtgaGacttgtgaccgatacatcag	12	12	10	7	1	1	2	1	2	0	1	1	4	1	2	1	1	1	2	1	1	3	4			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr5:148590346G>A	uc003lpy.2	+	7	884	c.633G>A	c.(631-633)GAG>GAA	p.E211E	ABLIM3_uc003lpz.1_Silent_p.E211E|ABLIM3_uc003lqa.1_Silent_p.E219E|ABLIM3_uc003lqb.2_Silent_p.E211E|ABLIM3_uc003lqc.1_Silent_p.E211E|ABLIM3_uc003lqd.1_Silent_p.E211E|ABLIM3_uc003lqf.2_Silent_p.E211E|ABLIM3_uc003lqe.1_Silent_p.E211E	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	211	LIM zinc-binding 4.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAAATGTGAGACTTGTGACC	0.478													41	115					0	0	0	0	A	148590346	A	A	148590346	2	1	106	1	0	0	0	0	0	0	0	1	96	933	33	2		2	ABLIM3	5	148590346	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	9388847	148590346	32324914	23	19837											
ATXN1	6310	broad.mit.edu	37	chr6	16328463	16328463	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagggtaggggccttctcctCggaggaccggctggtggcgg	4	7	19	11	3	1	0	0	0	1	0	3	2	1	2	3	9	0	2	3	9	1	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:16328463C>T	uc003nbt.2	-	8	1050	c.79G>A	c.(79-81)GAG>AAG	p.E27K	ATXN1_uc010jpi.2_Missense_Mutation_p.E27K|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	27					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GCCTTCTCCTCGGAGGACCGG	0.687													6	70					0	0	0	0	T	16328463	T	T	16328463	3	4	106	1	0	0	0	0	1	0	0	0	1211	893	31	1	2376	1	ATXN1	6	16328463	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08		16328463	154786604	24	19838											
PRL	5617	broad.mit.edu	37	chr6	22294767	22294767	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagatgggcaagggggccacGctctggcacaggagcaggtt	9	5	17	10	1	1	1	0	0	1	1	1	2	1	2	1	6	1	5	1	6	1	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:22294767G>A	uc003ndp.2	-	2	594	c.75C>T	c.(73-75)AGC>AGT	p.S25S	PRL_uc003ndo.2_Silent_p.S26S|PRL_uc003ndq.2_Silent_p.S25S|PRL_uc003ndr.1_RNA	NM_000948	NP_000939	P01236	PRL_HUMAN	prolactin precursor	25					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding				0	Ovarian(93;0.163)					AGGGGGCCACGCTCTGGCACA	0.592													4	26					0	0	0	0	A	22294767	A	A	22294767	2	1	106	1	0	0	0	0	0	0	0	1	12590	1078	38	1		1	PRL	6	22294767	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	5966304	22294767	148820300	25	19839											
KAAG1	353219	broad.mit.edu	37	chr6	24357907	24357907	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccgcgtagaaggggtccccGttgcggtacacaagcacgct	8	6	13	14	5	0	1	0	0	0	1	1	1	1	1	3	3	3	5	3	3	4	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:24357907G>A	uc003ndz.1	+	1	777	c.40G>A	c.(40-42)GTT>ATT	p.V14I	DCDC2_uc003ndx.2_Silent_p.N24N|DCDC2_uc003ndy.2_Silent_p.N24N	NM_181337	NP_851854	Q9UBP8	KAAG1_HUMAN	kidney associated antigen 1	14					immune response						0						AGGGGTCCCCGTTGCGGTACA	0.662													9	59					0	0	0	0	A	24357907	A	A	24357907	3	1	106	1	0	0	0	0	1	0	0	0	8012	1145	40	1	42	1	KAAG1	6	24357907	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	2063140	24357907	146757160	26	19840											
PKHD1	5314	broad.mit.edu	37	chr6	51875151	51875151	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtatctcagtaatcttgaCggtaattggctgattgggcg	8	13	12	8	3	2	2	1	2	2	0	3	2	2	2	1	3	0	4	1	3	3	6			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:51875151C>T	uc003pah.1	-	35	5983	c.5707G>A	c.(5707-5709)GTC>ATC	p.V1903I	PKHD1_uc003pai.2_Missense_Mutation_p.V1903I	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1903	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GTAATCTTGACGGTAATTGGC	0.393													6	37					0	0	0	0	T	51875151	T	T	51875151	3	4	106	1	0	0	0	0	1	0	0	0	12026	536	19	1	6688	1	PKHD1	6	51875151	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	27517244	51875151	119239916	27	19841											
KIAA1919	91749	broad.mit.edu	37	chr6	111588141	111588141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggattttgaaatgattgaaaCgaatgatacaatgaggcatt	16	12	10	3	1	0	5	0	5	0	0	0	7	0	6	0	2	2	1	0	2	5	5			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr6:111588141C>T	uc003puv.3	+	4	1798	c.1376C>T	c.(1375-1377)ACG>ATG	p.T459M		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	459	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		ATGATTGAAACGAATGATACA	0.398													5	50					0	0	0	0	T	111588141	T	T	111588141	3	4	106	1	0	0	0	0	1	0	0	0	8301	536	19	1	1390	1	KIAA1919	6	111588141	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	59712990	111588141	59526926	28	19842											
EPDR1	54749	broad.mit.edu	37	chr7	37988474	37988474	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tattttgctgtataaggatgGagtgatgtttcagattgacc	10	16	11	4	0	1	3	1	2	0	1	1	5	1	5	1	2	1	3	1	2	3	7			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:37988474G>C	uc003tfp.2	+	2	681	c.662G>C	c.(661-663)GGA>GCA	p.G221A	EPDR1_uc003tfq.2_Intron|EPDR1_uc010kxh.2_Missense_Mutation_p.G40A	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	101					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						TATAAGGATGGAGTGATGTTT	0.423													4	51					0	0	0	0	C	37988474	C	C	37988474	3	2	106	1	0	0	0	0	1	0	0	0	5187	1174	41	2	668	2	EPDR1	7	37988474	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08		37988474	121150189	29	19843											
ZNF716	441234	broad.mit.edu	37	chr7	57522286	57522286	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaactacagaaacctggtcTccctgggtgaggaaaacttc	13	8	10	10	0	1	3	0	1	1	2	3	4	1	4	2	3	4	0	2	3	5	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:57522286T>C	uc011kdi.1	+	2	272	c.160T>C	c.(160-162)TCC>CCC	p.S54P		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						AAACCTGGTCTCCCTGGGTGA	0.368													4	64					0	0	0	0	C	57522286	C	C	57522286	3	2	106	1	0	0	0	0	1	0	0	0	18186	1551	54	5	166	5	ZNF716	7	57522286	Missense_Mutation	SNP	T	TCGA-CQ-6224-01A-11D-1912-08	19533812	57522286	101616377	30	19844											
LHFPL3	375612	broad.mit.edu	37	chr7	104377219	104377219	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacagacaagtacactctTggggcttgctcagtccgctg	10	9	11	11	1	2	2	1	0	1	2	3	2	3	2	1	2	2	4	1	2	3	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:104377219T>C	uc003vce.2	+	2	667	c.543T>C	c.(541-543)CTT>CTC	p.L181L	LHFPL3_uc003vcf.2_Silent_p.L181L	NM_199000	NP_945351	Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	167						integral to membrane					0						AGTACACTCTTGGGGCTTGCT	0.473													7	25					0	0	0	0	C	104377219	C	C	104377219	2	2	106	1	0	0	0	0	0	0	0	1	8807	1799	63	5		5	LHFPL3	7	104377219	Silent	SNP	T	TCGA-CQ-6224-01A-11D-1912-08	46854933	104377219	54761444	31	19845											
LRRN3	54674	broad.mit.edu	37	chr7	110764283	110764283	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaacactagatataaatggCgtaactcccaaagaaggggg	16	6	12	7	1	0	2	0	0	0	2	1	3	1	3	1	4	2	1	1	4	8	4			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:110764283C>T	uc003vft.3	+	4	2501	c.1455C>T	c.(1453-1455)GGC>GGT	p.G485G	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Silent_p.G485G|LRRN3_uc003vfs.3_Silent_p.G485G	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	485	Extracellular (Potential).|Ig-like C2-type.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ATATAAATGGCGTAACTCCCA	0.408													8	71					0	0	0	0	T	110764283	T	T	110764283	2	4	106	1	0	0	0	0	0	0	0	1	9086	755	27	1		1	LRRN3	7	110764283	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	6387064	110764283	48374380	32	19846											
TAS2R60	338398	broad.mit.edu	37	chr7	143141158	143141158	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaatgattacttggacaatgCccactgctgtctttttcatt	10	16	6	9	0	2	1	1	1	1	0	2	2	2	2	1	1	3	1	1	1	3	5			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:143141158C>T	uc011ktg.1	+	1	613	c.613C>T	c.(613-615)CCC>TCC	p.P205S	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	205	Cytoplasmic (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					TTGGACAATGCCCACTGCTGT	0.448													4	152					0	0	0	0	T	143141158	T	T	143141158	3	4	106	1	0	0	0	0	1	0	0	0	15651	739	26	4	615	4	TAS2R60	7	143141158	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	32376875	143141158	15997505	33	19847											
TMEM176A	55365	broad.mit.edu	37	chr7	150500820	150500820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttattacaacagtgcctgccGcatctccagctcgagtgact	9	11	8	13	2	1	1	0	1	1	0	3	2	1	1	3	0	5	2	3	0	3	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:150500820G>A	uc003whx.1	+	5	533	c.455G>A	c.(454-456)CGC>CAC	p.R152H	TMEM176B_uc003whw.3_5'Flank	NM_018487	NP_060957	Q96HP8	T176A_HUMAN	hepatocellular carcinoma-associated antigen 112	152						integral to membrane				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGTGCCTGCCGCATCTCCAGC	0.512													29	74					0	0	0	0	A	150500820	A	A	150500820	3	1	106	1	0	0	0	0	1	0	0	0	16158	1087	38	1	469	1	TMEM176A	7	150500820	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	7359662	150500820	8637843	34	19848											
MLL3	58508	broad.mit.edu	37	chr7	151949691	151949691	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggatgataacacttcccaCagaagggacataagttatcc	14	9	8	10	0	0	2	0	1	0	1	2	4	2	4	2	2	1	1	2	2	4	4			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr7:151949691C>T	uc003wla.2	-	10	1628	c.1409G>A	c.(1408-1410)TGT>TAT	p.C470Y		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	470	DHHC-type.|PHD-type 3.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACACTTCCCACAGAAGGGACA	0.388			N		medulloblastoma								5	26					0	0	0	0	T	151949691	T	T	151949691	3	4	106	1	0	0	0	0	1	0	0	0	9675	478	17	4	13526	4	MLL3	7	151949691	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	1448871	151949691	7188972	35	19849											
EXTL3	2137	broad.mit.edu	37	chr8	28573798	28573798	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgggtggggaacgagctgtgCgaggtgaagcacgtgctgga	8	6	20	7	4	0	1	0	1	0	0	0	5	0	3	0	5	5	3	0	5	2	0			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:28573798C>T	uc003xgz.1	+	3	815	c.222C>T	c.(220-222)TGC>TGT	p.C74C		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	74	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		ACGAGCTGTGCGAGGTGAAGC	0.602													12	55					0	0	0	0	T	28573798	T	T	28573798	2	4	106	1	0	0	0	0	0	0	0	1	5352	776	27	1		1	EXTL3	8	28573798	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08		28573798	117790224	36	19850											
UNC5D	137970	broad.mit.edu	37	chr8	35606140	35606140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctttgcattgaccatccCgcactgtgcagatgtcagtt	7	13	8	13	1	1	2	1	1	0	1	3	2	3	2	3	0	2	4	3	0	0	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:35606140C>T	uc003xjr.1	+	12	2190	c.1862C>T	c.(1861-1863)CCG>CTG	p.P621L	UNC5D_uc003xjs.1_Missense_Mutation_p.P616L|UNC5D_uc003xju.1_Missense_Mutation_p.P197L	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	621	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTGACCATCCCGCACTGTGCA	0.493													5	116					0	0	0	0	T	35606140	T	T	35606140	3	4	106	1	0	0	0	0	1	0	0	0	17063	652	23	1	1908	1	UNC5D	8	35606140	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	7032342	35606140	110757882	37	19851											
OPRK1	4986	broad.mit.edu	37	chr8	54141973	54141973	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttcagtggaaagcagaagtCccggaaacaccgcttgaagt	13	7	11	10	2	1	2	1	1	0	1	2	4	2	4	2	2	2	2	2	2	4	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:54141973C>T	uc003xrh.1	-	3	1402	c.1027G>A	c.(1027-1029)GAC>AAC	p.D343N	OPRK1_uc003xri.1_Missense_Mutation_p.D343N|OPRK1_uc010lyc.1_Missense_Mutation_p.D254N	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	343	Cytoplasmic (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	AAGCAGAAGTCCCGGAAACAC	0.493													6	59					0	0	0	0	T	54141973	T	T	54141973	3	4	106	1	0	0	0	0	1	0	0	0	10939	855	30	2	119	2	OPRK1	8	54141973	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	18535833	54141973	92222049	38	19852											
TOP1MT	116447	broad.mit.edu	37	chr8	144392336	144392336	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggcctgcacactcagctgCgccagctgctcctgcagctt	5	9	11	16	1	1	0	1	0	0	0	2	0	2	0	3	1	7	6	3	1	0	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:144392336C>T	uc003yxz.2	-	13	1624	c.1605G>A	c.(1603-1605)GCG>GCA	p.A535A	TOP1MT_uc011lkd.1_Silent_p.A437A|TOP1MT_uc011lke.1_Silent_p.A437A|TOP1MT_uc010mfb.2_Silent_p.A437A|TOP1MT_uc011lkf.1_Silent_p.A330A	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	535					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	CACTCAGCTGCGCCAGCTGCT	0.642													4	23					0	0	0	0	T	144392336	T	T	144392336	2	4	106	1	0	0	0	0	0	0	0	1	16431	755	27	1		1	TOP1MT	8	144392336	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	90250363	144392336	1971686	39	19853											
SHARPIN	81858	broad.mit.edu	37	chr8	145154029	145154029	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcagctggctgggggcctggGggtagccccaatgatggggg	5	6	21	9	0	0	1	0	1	0	0	0	1	0	1	3	7	2	4	3	7	2	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:145154029G>A	uc003zba.2	-	7	1486	c.1002C>T	c.(1000-1002)CCC>CCT	p.P334P	SHARPIN_uc003zbb.2_Intron	NM_030974	NP_112236	Q9H0F6	SHRPN_HUMAN	shank-interacting protein-like 1	334					negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			ovary(1)	1	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGGGCCTGGGGGTAGCCCCA	0.662													3	41					0	0	0	0	A	145154029	A	A	145154029	2	1	106	1	0	0	0	0	0	0	0	1	14332	1219	43	4		4	SHARPIN	8	145154029	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	761693	145154029	1209993	40	19854											
GPR172A	79581	broad.mit.edu	37	chr8	145584283	145584283	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcggcctctctctgctGggcgtgttctgtgggggcta	1	12	17	11	2	3	0	0	0	3	0	4	0	3	0	1	5	1	3	1	5	1	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr8:145584283G>A	uc003zcc.1	+	4	1192	c.1035G>A	c.(1033-1035)CTG>CTA	p.L345L	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Silent_p.L345L|GPR172A_uc003zce.1_Silent_p.L345L|GPR172A_uc010mfy.1_Silent_p.L345L|GPR172A_uc003zcf.1_Silent_p.L345L|GPR172A_uc011llc.1_Silent_p.L257L	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	345	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			TCTCTCTGCTGGGCGTGTTCT	0.692													24	112					0	0	0	0	A	145584283	A	A	145584283	2	1	106	1	0	0	0	0	0	0	0	1	6707	1335	47	4		4	GPR172A	8	145584283	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	430254	145584283	779739	41	19855											
CDKN2A	1029	broad.mit.edu	37	chr9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcagctccgccactcGggcgctgcccatcatcatga	8	6	10	17	3	2	1	2	1	0	0	4	1	3	1	3	1	4	4	3	1	0	0	rs121913387		TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			4	14					0	0	0	0	A	21971186	A	A	21971186	4	1	106	1	0	0	0	0	0	1	0	0	3176	1125	39	1	306	1	CDKN2A	9	21971186	Nonsense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08		21971186	119242245	42	19856											
KLF9	687	broad.mit.edu	37	chr9	73002724	73002724	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccagcgcctttttcgatcGcttgatcatgctggggtgga	5	12	14	10	3	1	1	1	1	0	0	3	3	1	2	2	4	2	2	2	4	0	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr9:73002724G>A	uc004aht.2	-	2	1997	c.703C>T	c.(703-705)CGA>TGA	p.R235*		NM_001206	NP_001197	Q13886	KLF9_HUMAN	Kruppel-like factor 9	235					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTTTTCGATCGCTTGATCATG	0.597													14	69					0	0	0	0	A	73002724	A	A	73002724	4	1	106	1	0	0	0	0	0	1	0	0	8392	1095	38	1	35	1	KLF9	9	73002724	Nonsense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	51031538	73002724	68210707	43	19857											
PTPDC1	138639	broad.mit.edu	37	chr9	96863938	96863938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcttgatgtggtcttgggtgGagcaactgaaggagcctgta	8	11	16	6	0	1	2	0	2	1	0	1	4	1	4	1	4	3	3	1	4	3	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr9:96863938G>A	uc004auf.1	+	8	2282	c.1942G>A	c.(1942-1944)GAG>AAG	p.E648K	PTPDC1_uc004aug.1_Missense_Mutation_p.E643K|PTPDC1_uc004auh.1_Missense_Mutation_p.E700K|PTPDC1_uc010mrj.1_Missense_Mutation_p.E702K	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	648							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1						GTCTTGGGTGGAGCAACTGAA	0.463													14	88					0	0	0	0	A	96863938	A	A	96863938	3	1	106	1	0	0	0	0	1	0	0	0	12836	1175	41	2	2210	2	PTPDC1	9	96863938	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	23861214	96863938	44349493	44	19858											
ASTN2	23245	broad.mit.edu	37	chr9	119903652	119903652	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctgccgatgtgctgcgcAggggtggttgcagctgaccg	4	9	16	12	3	0	1	0	1	0	0	1	2	1	1	3	3	5	5	3	3	0	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr9:119903652A>G	uc004bjs.1	-	4	1222	c.1121T>C	c.(1120-1122)CTG>CCG	p.L374P	ASTN2_uc004bjr.1_Missense_Mutation_p.L374P|ASTN2_uc004bjt.1_Intron	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	374	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TGTGCTGCGCAGGGGTGGTTG	0.592													3	49					0	0	0	0	G	119903652	G	G	119903652	3	3	106	1	0	0	0	0	1	0	0	0	1067	203	7	5		5	ASTN2	9	119903652	Missense_Mutation	SNP	A	TCGA-CQ-6224-01A-11D-1912-08	23039714	119903652	21309779	45	19859											
SAR1A	56681	broad.mit.edu	37	chr10	71921643	71921643	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagcacactgctgaagccaTtgtagatccactcaaagatg	13	8	10	10	0	1	3	1	1	0	2	2	4	2	4	2	1	3	3	2	1	3	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr10:71921643T>C	uc010qjh.1	-	3	232	c.29A>G	c.(28-30)AAT>AGT	p.N10S	SAR1A_uc010qji.1_Missense_Mutation_p.N10S|SAR1A_uc010qjj.1_Intron	NM_001142648	NP_001136120	Q9NR31	SAR1A_HUMAN	SAR1a gene homolog 1	10					ER to Golgi vesicle-mediated transport|intracellular protein transport	Golgi apparatus	GTP binding|GTPase activity				0						GCTGAAGCCATTGTAGATCCA	0.358													4	31					0	0	0	0	C	71921643	C	C	71921643	3	2	106	1	0	0	0	0	1	0	0	0	13904	1493	52	5	591	5	SAR1A	10	71921643	Missense_Mutation	SNP	T	TCGA-CQ-6224-01A-11D-1912-08		71921643	63613104	46	19860											
EXOC6	54536	broad.mit.edu	37	chr10	94818062	94818062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagaagttgatagagacaGtcgtgaaacagctgagaagt	17	7	12	5	1	0	5	0	3	0	3	1	7	0	5	0	0	3	2	0	0	5	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr10:94818062G>A	uc001kig.2	+	22	2431	c.2365G>A	c.(2365-2367)GTC>ATC	p.V789I	EXOC6_uc010qnr.1_Missense_Mutation_p.V805I|EXOC6_uc001kie.2_Missense_Mutation_p.V784I|EXOC6_uc009xub.2_Missense_Mutation_p.V788I|EXOC6_uc009xuc.2_Missense_Mutation_p.V686I|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Missense_Mutation_p.V363I|CYP26C1_uc010qns.1_5'Flank|CYP26C1_uc009xud.2_5'Flank	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	789					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				GATAGAGACAGTCGTGAAACA	0.398													8	43					0	0	0	0	A	94818062	A	A	94818062	3	1	106	1	0	0	0	0	1	0	0	0	5332	1029	36	4	2541	4	EXOC6	10	94818062	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	22896419	94818062	40716685	47	19861											
PYROXD2	84795	broad.mit.edu	37	chr10	100148126	100148126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttacctctgtctgcataagCgtctctctcctgctcgtccc	4	15	6	16	2	4	0	0	0	4	0	8	0	5	0	3	0	4	2	3	0	2	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr10:100148126C>T	uc001kpc.2	-	13	1518	c.1432G>A	c.(1432-1434)GCT>ACT	p.A478T	PYROXD2_uc001kpb.2_Intron|PYROXD2_uc001kpd.2_Intron	NM_032709	NP_116098	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase	478							oxidoreductase activity			central_nervous_system(1)	1						TCTGCATAAGCGTCTCTCTCC	0.612													8	26					0	0	0	0	T	100148126	T	T	100148126	3	4	106	1	0	0	0	0	1	0	0	0	12932	768	27	1	329	1	PYROXD2	10	100148126	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	5330064	100148126	35386621	48	19862											
DMBT1	1755	broad.mit.edu	37	chr10	124339094	124339094	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gttcttgtgttcccctgtagGatctgaatccagtttggccc	5	15	10	11	0	2	1	0	1	2	0	4	2	4	2	4	2	0	4	4	2	2	5			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr10:124339094G>T	uc001lgk.1	+	10	786	c.680G>T	c.(679-681)GGA>GTA	p.G227V	DMBT1_uc001lgl.1_Missense_Mutation_p.G227V|DMBT1_uc001lgm.1_Missense_Mutation_p.G227V|DMBT1_uc009xzz.1_Missense_Mutation_p.G227V|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Missense_Mutation_p.G79V	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	227					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TCCCCTGTAGGATCTGAATCC	0.527													39	391					6.19805e-25	6.94933e-25	1	0	T	124339094	T	T	124339094	3	4	106	1	0	0	0	0	1	0	0	0	4599	1188	41	2	718	2	DMBT1	10	124339094	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	24190968	124339094	11195653	49	19863											
DBX1	120237	broad.mit.edu	37	chr11	20177857	20177857	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gactgctcgagtgcgcgggcGaggggggcagcggccctggc	4	4	21	12	5	0	0	0	0	0	0	1	3	0	0	1	6	3	2	1	6	0	0			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:20177857G>A	uc001mpw.1	-	4	1052	c.1052C>T	c.(1051-1053)TCG>TTG	p.S351L		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	312					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTGCGCGGGCGAGGGGGGCAG	0.701													10	68					0	0	0	0	A	20177857	A	A	20177857	3	1	106	1	0	0	0	0	1	0	0	0	4276	1059	37	1	100	1	DBX1	11	20177857	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08		20177857	114828659	50	19864											
HIPK3	10114	broad.mit.edu	37	chr11	33308667	33308667	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatcatccttcttatgcccGtcaaggtcaaatagaagtga	13	11	8	9	1	4	2	3	1	1	1	5	3	5	2	2	1	1	0	2	1	6	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:33308667G>A	uc001mul.1	+	2	977	c.707G>A	c.(706-708)CGT>CAT	p.R236H	HIPK3_uc001mum.1_Missense_Mutation_p.R236H|HIPK3_uc009yjv.1_Missense_Mutation_p.R236H	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	236	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						TCTTATGCCCGTCAAGGTCAA	0.398													3	32					0	0	0	0	A	33308667	A	A	33308667	3	1	106	1	0	0	0	0	1	0	0	0	7157	1145	40	1	709	1	HIPK3	11	33308667	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	13130810	33308667	101697849	51	19865											
MRPL21	219927	broad.mit.edu	37	chr11	68658835	68658835	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcaatctcaatgctgtttatCcggaggacagtctgcggggt	8	11	13	9	2	2	0	1	0	2	0	4	2	3	2	1	4	2	3	1	4	3	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:68658835C>T	uc001ooi.2	-	7	607	c.582G>A	c.(580-582)CGG>CGA	p.R194R	MRPL21_uc001ooh.2_Silent_p.R109R	NM_181514	NP_852615	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21 isoform d	194					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGCTGTTTATCCGGAGGACAG	0.473													12	235					0	0	0	0	T	68658835	T	T	68658835	2	4	106	1	0	0	0	0	0	0	0	1	9840	842	30	2		2	MRPL21	11	68658835	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	35350168	68658835	66347681	52	19866											
GAB2	9846	broad.mit.edu	37	chr11	77991788	77991788	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cacaaaactatcctgcagctCcttcttgttaaaggtcaggc	11	11	7	12	0	2	0	1	0	1	0	4	0	4	0	2	2	3	3	2	2	5	4			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:77991788C>G	uc001ozh.2	-	2	235	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	GAB2_uc001ozg.2_Missense_Mutation_p.E41Q	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	79	PH.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TCCTGCAGCTCCTTCTTGTTA	0.473													19	136					0	0	0	0	G	77991788	G	G	77991788	3	3	106	1	0	0	0	0	1	0	0	0	6183	864	30	2	1831	2	GAB2	11	77991788	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	9332953	77991788	57014728	53	19867											
ST14	6768	broad.mit.edu	37	chr11	130078332	130078332	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccccacgcagtggacggcCttcctgggcttgcacgacca	7	6	12	16	3	0	0	0	0	0	0	1	3	1	1	5	3	1	3	5	3	0	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr11:130078332C>T	uc001qfw.2	+	17	2215	c.2022C>T	c.(2020-2022)GCC>GCT	p.A674A		NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	674	Extracellular (Potential).|Peptidase S1.			A -> V (in Ref. 3; BAB20376).	proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	AGTGGACGGCCTTCCTGGGCT	0.662													12	36					0	0	0	0	T	130078332	T	T	130078332	2	4	106	1	0	0	0	0	0	0	0	1	15277	668	24	4		4	ST14	11	130078332	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	52086544	130078332	4928184	54	19868											
TENC1	23371	broad.mit.edu	37	chr12	53447568	53447568	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccctctagcggcgaaacaCggccccagtcaggcgcatag	9	5	11	16	4	2	0	1	0	1	0	3	1	3	0	3	3	2	1	3	3	3	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr12:53447568C>A	uc001sbp.2	+	5	407	c.272C>A	c.(271-273)ACG>AAG	p.T91K	uc001sbk.1_Intron|TENC1_uc001sbl.2_5'UTR|TENC1_uc001sbm.2_Missense_Mutation_p.T101K|TENC1_uc001sbn.2_Missense_Mutation_p.T101K|TENC1_uc001sbo.1_Missense_Mutation_p.T91K	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	91					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						CGGCGAAACACGGCCCCAGTC	0.567											OREG0021855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	35					0.000978159	0.001044	1	0	A	53447568	A	A	53447568	3	1	106	1	0	0	0	0	1	0	0	0	15824	536	19	3	399	3	TENC1	12	53447568	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08		53447568	80404327	55	19869											
STAB2	55576	broad.mit.edu	37	chr12	104089380	104089380	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttaccaaacctgctcatgcGgctggaacagatgcctgact	10	9	9	13	1	1	2	1	1	0	1	1	3	1	3	3	2	6	2	3	2	3	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr12:104089380G>C	uc001tjw.2	+	32	3614	c.3428G>C	c.(3427-3429)CGG>CCG	p.R1143P		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1143	Extracellular (Potential).|FAS1 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CTGCTCATGCGGCTGGAACAG	0.502													28	99					0	0	0	0	C	104089380	C	C	104089380	3	2	106	1	0	0	0	0	1	0	0	0	15304	1116	39	3	3554	3	STAB2	12	104089380	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	50641812	104089380	29762515	56	19870											
ATP8A2	51761	broad.mit.edu	37	chr13	26343230	26343230	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagtggatgtggtgaagaagCgggtgaaggccatcaccctc	10	8	15	8	1	1	3	1	2	0	1	2	4	1	4	2	4	1	0	2	4	4	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr13:26343230C>T	uc001uqk.2	+	26	2573	c.2431C>T	c.(2431-2433)CGG>TGG	p.R811W	ATP8A2_uc010tdi.1_Missense_Mutation_p.R771W|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.R361W	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	771	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GGTGAAGAAGCGGGTGAAGGC	0.537													22	62					0	0	0	0	T	26343230	T	T	26343230	3	4	106	1	0	0	0	0	1	0	0	0	1195	759	27	1	2533	1	ATP8A2	13	26343230	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08		26343230	88826648	57	19871											
CCNA1	8900	broad.mit.edu	37	chr13	37011811	37011811	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggatcagaaaatgccttcCctccagctggaaagaaagca	14	7	9	11	0	1	2	1	0	0	2	3	4	3	4	3	2	3	2	3	2	4	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr13:37011811C>G	uc001uvr.3	+	3	693	c.343C>G	c.(343-345)CCT>GCT	p.P115A	CCNA1_uc010teo.1_Missense_Mutation_p.P71A|CCNA1_uc010abq.2_Missense_Mutation_p.P71A|CCNA1_uc010abp.2_Missense_Mutation_p.P71A|CCNA1_uc001uvs.3_Missense_Mutation_p.P114A|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	115					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		AAATGCCTTCCCTCCAGCTGG	0.478													6	92					0	0	0	0	G	37011811	G	G	37011811	3	3	106	1	0	0	0	0	1	0	0	0	2924	623	22	4	353	4	CCNA1	13	37011811	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	10668581	37011811	78158067	58	19872											
GALNTL1	57452	broad.mit.edu	37	chr14	69787431	69787431	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgaccttcatctcaggtgAcaggaactccctcgaaaggc	10	8	10	13	1	2	2	2	2	1	0	5	4	3	3	2	3	1	1	2	3	2	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr14:69787431A>T	uc010aqu.1	+	2	274	c.181A>T	c.(181-183)ACA>TCA	p.T61S	GALNTL1_uc001xla.1_Missense_Mutation_p.T61S|GALNTL1_uc001xlb.1_Missense_Mutation_p.T61S	NM_020692	NP_065743	Q8N428	GLTL1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	61	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)		ATCTCAGGTGACAGGAACTCC	0.607													7	86					0	0	0	0	T	69787431	T	T	69787431	3	4	106	1	0	0	0	0	1	0	0	0	6256	275	10	5	187	5	GALNTL1	14	69787431	Missense_Mutation	SNP	A	TCGA-CQ-6224-01A-11D-1912-08		69787431	37562109	59	19873											
SYNJ2BP	55333	broad.mit.edu	37	chr14	70842394	70842394	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctcaaagtgatacctaccCtgtgctgcactctcagagac	10	9	9	13	0	2	2	2	1	1	1	3	3	2	2	2	1	4	3	2	1	3	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr14:70842394C>T	uc001xmc.3	-	3	423	c.296G>A	c.(295-297)AGG>AAG	p.R99K	SYNJ2BP_uc010arc.2_RNA	NM_018373	NP_060843	P57105	SYJ2B_HUMAN	synaptojanin 2 binding protein	99	PDZ.|Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane					0				all cancers(60;0.00367)|BRCA - Breast invasive adenocarcinoma(234;0.00716)|OV - Ovarian serous cystadenocarcinoma(108;0.0377)		GATACCTACCCTGTGCTGCAC	0.463													22	112					0	0	0	0	T	70842394	T	T	70842394	3	4	106	1	0	0	0	0	1	0	0	0	15520	695	24	4	149	4	SYNJ2BP	14	70842394	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	1054963	70842394	36507146	60	19874											
TC2N	123036	broad.mit.edu	37	chr14	92258736	92258736	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttgaaggtggtgttataTccaaagagtaatccatttcc	11	16	8	6	0	0	2	0	1	0	1	3	2	3	2	3	2	0	2	3	2	5	6			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr14:92258736T>A	uc001xzu.3	-	9	1213	c.1022A>T	c.(1021-1023)GAT>GTT	p.D341V	TC2N_uc001xzt.3_Missense_Mutation_p.D341V|TC2N_uc010auc.2_Intron|TC2N_uc001xzv.3_Missense_Mutation_p.D341V	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	341						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		TGGTGTTATATCCAAAGAGTA	0.363													22	69					0	0	0	0	A	92258736	A	A	92258736	3	1	106	1	0	0	0	0	1	0	0	0	15731	1435	50	5	466	5	TC2N	14	92258736	Missense_Mutation	SNP	T	TCGA-CQ-6224-01A-11D-1912-08	21416342	92258736	15090804	61	19875											
CHGA	1113	broad.mit.edu	37	chr14	93397703	93397703	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccaggccccaggccctccCggagcccatgcaggagtcca	8	3	12	18	1	0	0	0	0	0	0	2	2	2	2	7	4	3	1	7	4	0	0			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr14:93397703C>A	uc001ybc.3	+	6	724	c.464C>A	c.(463-465)CCG>CAG	p.P155Q	CHGA_uc010aum.2_RNA|CHGA_uc001ybd.3_Intron	NM_001275	NP_001266	P10645	CMGA_HUMAN	chromogranin A precursor	155					regulation of blood pressure	extracellular region|stored secretory granule				skin(2)	2		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		CAGGCCCTCCCGGAGCCCATG	0.522													3	36					0.004672	0.00493897	1	0	A	93397703	A	A	93397703	3	1	106	1	0	0	0	0	1	0	0	0	3353	652	23	3	486	3	CHGA	14	93397703	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	1138967	93397703	13951837	62	19876											
NDNL2	56160	broad.mit.edu	37	chr15	29561416	29561416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttggtcacccctcatctcgGcatcctcctccacaggctcc	5	10	6	20	1	3	0	2	0	1	0	8	0	7	0	6	3	0	2	6	3	0	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr15:29561416G>A	uc001zco.2	-	1	602	c.494C>T	c.(493-495)GCC>GTC	p.A165V	FAM189A1_uc010azk.1_Intron	NM_138704	NP_619649	Q96MG7	MAGG1_HUMAN	necdin-like 2	165	MAGE.				regulation of growth	cytoplasm|nucleus					0		all_lung(180;4.69e-11)|Breast(32;0.0013)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00736)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CCTCATCTCGGCATCCTCCTC	0.547													4	111					0	0	0	0	A	29561416	A	A	29561416	3	1	106	1	0	0	0	0	1	0	0	0	10302	1203	42	4	424	4	NDNL2	15	29561416	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08		29561416	72969976	63	19877											
EIF2AK4	440275	broad.mit.edu	37	chr15	40293317	40293317	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatgaagtgctgcaccaCacgctgaccaacgtggatgg	10	7	12	12	2	0	2	0	2	0	0	0	3	0	3	2	2	4	4	2	2	2	0			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr15:40293317C>A	uc001zkm.1	+	21	3101	c.3051C>A	c.(3049-3051)CAC>CAA	p.H1017Q	EIF2AK4_uc010bbj.1_Missense_Mutation_p.H718Q|EIF2AK4_uc001zkn.1_Missense_Mutation_p.H117Q|EIF2AK4_uc001zko.1_5'Flank	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	1017					translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TGCTGCACCACACGCTGACCA	0.587													6	39					3.59834e-05	3.87782e-05	1	0	A	40293317	A	A	40293317	3	1	106	1	0	0	0	0	1	0	0	0	5021	477	17	4	3133	4	EIF2AK4	15	40293317	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	10731901	40293317	62238075	64	19878											
IRX5	10265	broad.mit.edu	37	chr16	54966559	54966559	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accctcaaggcctggctcaaCgagcaccgcaagaaccccta	12	4	8	17	2	2	1	2	0	0	1	2	2	2	1	5	2	3	3	5	2	5	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr16:54966559C>T	uc002ehv.2	+	2	399	c.399C>T	c.(397-399)AAC>AAT	p.N133N	IRX5_uc010cca.1_Silent_p.N185N|IRX5_uc002ehw.2_Silent_p.N67N	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	133	Homeobox; TALE-type.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						CCTGGCTCAACGAGCACCGCA	0.627													18	88					0	0	0	0	T	54966559	T	T	54966559	2	4	106	1	0	0	0	0	0	0	0	1	7886	535	19	1		1	IRX5	16	54966559	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08		54966559	35388194	65	19879											
C16orf48	84080	broad.mit.edu	37	chr16	67700077	67700077	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atctctccggcaccgggaccGatgcaggggccacggggagc	7	4	16	14	4	1	0	0	0	1	0	3	3	2	2	4	6	2	2	4	6	0	0			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr16:67700077G>A	uc002etw.1	-	2	460	c.177C>T	c.(175-177)ATC>ATT	p.I59I	C16orf48_uc002etv.1_5'Flank|C16orf48_uc010cem.1_Silent_p.I59I|C16orf86_uc002etx.1_5'Flank|C16orf86_uc002ety.2_5'Flank|C16orf86_uc002etz.2_5'Flank	NM_032140	NP_115516	Q9H0I2	CP048_HUMAN	hypothetical protein LOC84080	59						microtubule cytoskeleton	protein binding				0		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CACCGGGACCGATGCAGGGGC	0.697													5	59					0	0	0	0	A	67700077	A	A	67700077	2	1	106	1	0	0	0	0	0	0	0	1	1822	1048	37	1		1	C16orf48	16	67700077	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	12733518	67700077	22654676	66	19880											
ZFPM1	161882	broad.mit.edu	37	chr16	88601287	88601287	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgcccaacggcaaccaccGgtactgccgtctttgcaaca	9	7	9	16	3	1	0	0	0	1	0	1	0	1	0	4	2	7	4	4	2	4	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr16:88601287G>C	uc002fkv.2	+	10	2954	c.2921G>C	c.(2920-2922)CGG>CCG	p.R974P		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	974	C2HC-type 5.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GGCAACCACCGGTACTGCCGT	0.527													7	40					0	0	0	0	C	88601287	C	C	88601287	3	2	106	1	0	0	0	0	1	0	0	0	17724	1116	39	3	2959	3	ZFPM1	16	88601287	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	20901210	88601287	1753466	67	19881											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	6	9	15	11	2	1	2	1	2	0	0	2	3	2	3	4	4	2	2	4	4	0	1	rs11540652		TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	63					0	0	0	0	T	7577538	T	T	7577538	3	4	106	1	0	0	0	0	1	0	0	0	16448	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08		7577538	73617672	68	19882											
DNAH2	146754	broad.mit.edu	37	chr17	7734412	7734412	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgactccctaggttgtcagCactggagacttatttcatcc	9	13	8	11	0	2	2	2	1	0	1	4	3	4	2	2	2	1	2	2	2	2	4			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:7734412C>G	uc002giu.1	+	79	12253	c.12239C>G	c.(12238-12240)GCA>GGA	p.A4080G	DNAH2_uc010cnm.1_Missense_Mutation_p.A1018G	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4080	TPR 4.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGGTTGTCAGCACTGGAGACT	0.517													4	301					0	0	0	0	G	7734412	G	G	7734412	3	3	106	1	0	0	0	0	1	0	0	0	4624	710	25	4	12553	4	DNAH2	17	7734412	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	156874	7734412	73460798	69	19883											
KCNH4	23415	broad.mit.edu	37	chr17	40322231	40322231	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttagagtgaagtacagtgcCgcgatgtaggcgctgcgccg	8	8	15	10	5	0	2	0	1	0	1	0	3	0	2	2	1	3	3	2	1	4	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:40322231C>T	uc002hzb.2	-	8	1617	c.1284G>A	c.(1282-1284)GCG>GCA	p.A428A		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	428					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGTACAGTGCCGCGATGTAGG	0.602													15	27					0	0	0	0	T	40322231	T	T	40322231	2	4	106	1	0	0	0	0	0	0	0	1	8073	639	23	1		1	KCNH4	17	40322231	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	32587819	40322231	40872979	70	19884											
OR4D1	26689	broad.mit.edu	37	chr17	56232955	56232955	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgggcctggtagtagcCgcctgggtggggggctttgt	2	12	20	7	1	0	0	0	0	0	0	0	0	0	0	3	6	1	3	3	6	2	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:56232955C>T	uc010wno.1	+	1	441	c.441C>T	c.(439-441)GCC>GCT	p.A147A	MSX2P1_uc002ivn.2_5'Flank	NM_012374	NP_036506	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGGTAGTAGCCGCCTGGGTGG	0.532													21	59					0	0	0	0	T	56232955	T	T	56232955	2	4	106	1	0	0	0	0	0	0	0	1	11107	639	23	1		1	OR4D1	17	56232955	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	15910724	56232955	24962255	71	19885											
RGS9	8787	broad.mit.edu	37	chr17	63206625	63206625	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctccaccctcccttttatgCggcgtcacctgcgctccagc	4	10	8	19	3	1	0	1	0	0	0	4	0	4	0	5	1	3	2	5	1	1	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:63206625C>T	uc002jfe.2	+	17	1419	c.1309C>T	c.(1309-1311)CGG>TGG	p.R437W	RGS9_uc010dem.2_Missense_Mutation_p.R434W|RGS9_uc002jfd.2_Missense_Mutation_p.R434W|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.R208W	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	437					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						CCCTTTTATGCGGCGTCACCT	0.572													4	128					0	0	0	0	T	63206625	T	T	63206625	3	4	106	1	0	0	0	0	1	0	0	0	13378	759	27	1	1375	1	RGS9	17	63206625	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	6973670	63206625	17988585	72	19886											
PCYT2	5833	broad.mit.edu	37	chr17	79866789	79866789	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcacagttgtatttgtccagGgtctctagtgtagtgacgta	8	15	11	7	1	2	1	1	1	1	0	4	1	3	1	1	1	0	4	1	1	4	6			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr17:79866789G>A	uc002kcf.1	-	3	366	c.303C>T	c.(301-303)ACC>ACT	p.T101T	PCYT2_uc010wva.1_Silent_p.T69T|PCYT2_uc010wvb.1_Silent_p.T69T|PCYT2_uc002kce.1_Silent_p.T23T|PCYT2_uc002kcg.1_Silent_p.T112T|PCYT2_uc002kch.1_Silent_p.T101T|PCYT2_uc002kci.1_Silent_p.T42T|PCYT2_uc010dii.1_Silent_p.T101T|PCYT2_uc010wvc.1_Silent_p.T23T	NM_002861	NP_002852	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	101	Catalytic 1 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			ATTTGTCCAGGGTCTCTAGTG	0.587													10	84					0	0	0	0	A	79866789	A	A	79866789	2	1	106	1	0	0	0	0	0	0	0	1	11666	1219	43	4		4	PCYT2	17	79866789	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	16660164	79866789	1328421	73	19887											
EPB41L3	23136	broad.mit.edu	37	chr18	5396229	5396229	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcatatgtgatggttttggTttcggtgtgaactactggca	7	17	12	5	1	1	2	1	2	0	0	2	2	1	2	0	4	2	3	0	4	3	6			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr18:5396229T>G	uc002kmt.1	-	19	3030	c.2944A>C	c.(2944-2946)ACC>CCC	p.T982P	EPB41L3_uc010wzh.1_Missense_Mutation_p.T813P|EPB41L3_uc002kmu.1_Missense_Mutation_p.T760P|EPB41L3_uc010dkq.1_Missense_Mutation_p.T651P|EPB41L3_uc002kms.1_Missense_Mutation_p.T217P|EPB41L3_uc010wze.1_Missense_Mutation_p.T287P|EPB41L3_uc010wzf.1_Missense_Mutation_p.T279P|EPB41L3_uc010wzg.1_Missense_Mutation_p.T254P|EPB41L3_uc010dkr.2_Missense_Mutation_p.T374P	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	982	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						ATGGTTTTGGTTTCGGTGTGA	0.458													5	187					0	0	0	0	G	5396229	G	G	5396229	3	3	106	1	0	0	0	0	1	0	0	0	5178	1725	60	5	335	5	EPB41L3	18	5396229	Missense_Mutation	SNP	T	TCGA-CQ-6224-01A-11D-1912-08		5396229	72681019	74	19888											
TCEB3B	51224	broad.mit.edu	37	chr18	44561118	44561118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccggaggggagctgtgcgcGttggagaggcccgatagcgg	6	6	20	9	5	0	1	0	0	0	1	1	5	1	3	2	6	3	2	2	6	1	2			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr18:44561118G>A	uc002lcr.1	-	1	871	c.518C>T	c.(517-519)ACG>ATG	p.T173M	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	173					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						AGCTGTGCGCGTTGGAGAGGC	0.687													7	71					0	0	0	0	A	44561118	A	A	44561118	3	1	106	1	0	0	0	0	1	0	0	0	15748	1145	40	1	1747	1	TCEB3B	18	44561118	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	39164889	44561118	33516130	75	19889											
ICAM5	7087	broad.mit.edu	37	chr19	10404565	10404565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgcgggcacttaccgctgcGaagccaccaaccctcggggc	8	5	12	16	4	0	0	0	0	0	0	1	1	0	0	4	3	5	2	4	3	3	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:10404565G>A	uc002mnu.3	+	7	1722	c.1657G>A	c.(1657-1659)GAA>AAA	p.E553K	ICAM5_uc002mnv.3_Missense_Mutation_p.E428K	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	553	Extracellular (Potential).|Ig-like C2-type 6.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			TTACCGCTGCGAAGCCACCAA	0.652													12	42					0	0	0	0	A	10404565	A	A	10404565	3	1	106	1	0	0	0	0	1	0	0	0	7522	1059	37	1	1683	1	ICAM5	19	10404565	Missense_Mutation	SNP	G	TCGA-CQ-6224-01A-11D-1912-08		10404565	48724418	76	19890											
DCAF15	90379	broad.mit.edu	37	chr19	14070879	14070879	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccactgaggagggccagctCcggtgagcgcggggatcctg	6	5	17	13	3	0	2	0	2	0	0	2	4	2	4	4	5	2	1	4	5	0	0			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:14070879C>T	uc002mxt.2	+	10	1530	c.1524C>T	c.(1522-1524)CTC>CTT	p.L508L	DCAF15_uc002mxu.2_RNA	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	508										central_nervous_system(1)	1						AGGGCCAGCTCCGGTGAGCGC	0.667											OREG0025301	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	25					0	0	0	0	T	14070879	T	T	14070879	2	4	106	1	0	0	0	0	0	0	0	1	4284	842	30	2		2	DCAF15	19	14070879	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	3666314	14070879	45058104	77	19891											
CD97	976	broad.mit.edu	37	chr19	14517888	14517888	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcagggcgctgaccatcacGgccatcgcgcagctcttcct	6	7	11	17	5	2	1	1	1	1	0	4	1	3	1	3	2	1	4	3	2	0	1	rs141170739	byFrequency	TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:14517888G>A	uc002myl.2	+	18	2346	c.2223G>A	c.(2221-2223)ACG>ACA	p.T741T	CD97_uc002mym.2_Silent_p.T692T|CD97_uc002myn.2_Silent_p.T648T	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	741	Helical; Name=6; (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						TGACCATCACGGCCATCGCGC	0.637													11	68					0	0	0	0	A	14517888	A	A	14517888	2	1	106	1	0	0	0	0	0	0	0	1	3064	1103	39	1		1	CD97	19	14517888	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	447009	14517888	44611095	78	19892											
SPTBN4	57731	broad.mit.edu	37	chr19	41073713	41073714	+	Frame_Shift_Ins	INS	-	C	C																															aaggggcttggagcccctggINScccgccgagcctcggacacg																										TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:41073713_41073714insC	uc002ony.2	+	31	6567_6568	c.6481_6482insC	c.(6481-6483)GCCfs	p.A2161fs	SPTBN4_uc002onz.2_Frame_Shift_Ins_p.A2161fs|SPTBN4_uc010egx.2_Frame_Shift_Ins_p.A904fs	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	2161					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGAGCCCCTGGCCCGCCGAGCC	0.718													---	---	---								C	41073714	C	C	41073713	7	5	106	1	0	1	1	0	0	0	0	0	15187	1203	42	0	6693	0	SPTBN4	19	41073713	Frame_Shift_Ins	INS	-	TCGA-CQ-6224-01A-11D-1912-08	26555825	41073713	18055270	79	19893											
PTOV1	53635	broad.mit.edu	37	chr19	50357788	50357788	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggcttggagcggcgtcctCgagtggcaggaggtgagtct	5	9	18	9	3	1	1	0	1	1	0	3	4	2	3	1	6	1	2	1	6	0	1			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:50357788C>T	uc002pqf.1	+	2	467	c.297C>T	c.(295-297)CTC>CTT	p.L99L	uc002ppy.3_5'Flank|PTOV1_uc010ybf.1_Silent_p.L67L|PTOV1_uc002ppz.3_RNA|PTOV1_uc002pqb.3_Silent_p.L67L|PTOV1_uc002pqa.2_RNA|PTOV1_uc002pqc.1_RNA|PTOV1_uc002pqd.2_RNA|PTOV1_uc002pqe.1_RNA	NM_017432	NP_059128	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		GCGGCGTCCTCGAGTGGCAGG	0.672													5	64					0	0	0	0	T	50357788	T	T	50357788	2	4	106	1	0	0	0	0	0	0	0	1	12832	871	31	1		1	PTOV1	19	50357788	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	9284075	50357788	8771195	80	19894											
TMEM190	147744	broad.mit.edu	37	chr19	55889198	55889198	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggaggaagcacatgtgggcGctggtctggacgtgcagcgg	7	6	19	9	4	1	0	0	0	1	0	1	3	1	3	0	6	3	3	0	6	1	0			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:55889198G>A	uc002qkt.1	+	4	267	c.249G>A	c.(247-249)GCG>GCA	p.A83A		NM_139172	NP_631911	Q8WZ59	TM190_HUMAN	transmembrane protein 190 precursor	83	Helical; (Potential).					integral to membrane					0	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		ACATGTGGGCGCTGGTCTGGA	0.692													5	64					0	0	0	0	A	55889198	A	A	55889198	2	1	106	1	0	0	0	0	0	0	0	1	16180	1074	38	1		1	TMEM190	19	55889198	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08	5531410	55889198	3239785	81	19895											
ZNF549	256051	broad.mit.edu	37	chr19	58049987	58049987	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaatgtggaaaagtcttcAgccaccaaaaaagacttctt	16	10	7	8	0	3	2	1	1	2	1	3	3	3	3	2	1	1	0	2	1	6	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr19:58049987A>G	uc002qpb.1	+	4	1864	c.1615A>G	c.(1615-1617)AGC>GGC	p.S539G	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Missense_Mutation_p.S526G	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	539	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAAAGTCTTCAGCCACCAAAA	0.443													4	56					0	0	0	0	G	58049987	G	G	58049987	3	3	106	1	0	0	0	0	1	0	0	0	18048	188	7	5	1586	5	ZNF549	19	58049987	Missense_Mutation	SNP	A	TCGA-CQ-6224-01A-11D-1912-08	2160789	58049987	1078996	82	19896											
GDF5	8200	broad.mit.edu	37	chr20	34022565	34022565	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtacctctgcttcctgacCacgggacctcggtcatctag	7	10	9	15	3	3	1	1	1	2	0	5	2	4	2	4	2	2	2	4	2	2	3			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chr20:34022565C>T	uc010gfc.1	-	2	889	c.648G>A	c.(646-648)GTG>GTA	p.V216V	uc002xcj.2_Missense_Mutation_p.H326Y|GDF5_uc002xck.1_Silent_p.V216V|GDF5_uc010zvc.1_Silent_p.V216V	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	216					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GCTTCCTGACCACGGGACCTC	0.612													38	151					0	0	0	0	T	34022565	T	T	34022565	2	4	106	1	0	0	0	0	0	0	0	1	6353	581	21	4		4	GDF5	20	34022565	Silent	SNP	C	TCGA-CQ-6224-01A-11D-1912-08		34022565	29002955	83	19897											
USP9X	8239	broad.mit.edu	37	chrX	41077799	41077799	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttattgcacatttttccttGcaagatgggccatgtccttc	7	17	7	10	0	0	1	0	0	0	1	3	1	2	1	3	1	2	2	3	1	2	7			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chrX:41077799G>A	uc004dfb.2	+	37	7017	c.6384G>A	c.(6382-6384)TTG>TTA	p.L2128L	USP9X_uc004dfc.2_Silent_p.L2128L	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2128					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						ATTTTTCCTTGCAAGATGGGC	0.413													37	44					0	0	0	0	A	41077799	A	A	41077799	2	1	106	1	0	0	0	0	0	0	0	1	17158	1310	46	4		4	USP9X	23	41077799	Silent	SNP	G	TCGA-CQ-6224-01A-11D-1912-08		41077799	114192761	84	19898											
OGT	8473	broad.mit.edu	37	chrX	70776891	70776891	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggagccttgcagtgttataCgcgtgccatccaaattaatc	10	11	10	10	2	0	0	0	0	0	0	2	1	1	1	3	1	4	2	3	1	4	4			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chrX:70776891C>T	uc004eaa.1	+	10	1473	c.1256C>T	c.(1255-1257)ACG>ATG	p.T419M	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.T409M|OGT_uc004eac.2_Missense_Mutation_p.T280M|OGT_uc004ead.2_Missense_Mutation_p.T38M	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	419	TPR 11.				cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					CAGTGTTATACGCGTGCCATC	0.403													3	17					0	0	0	0	T	70776891	T	T	70776891	3	4	106	1	0	0	0	0	1	0	0	0	10901	536	19	1	1294	1	OGT	23	70776891	Missense_Mutation	SNP	C	TCGA-CQ-6224-01A-11D-1912-08	29699092	70776891	84493669	85	19899											
ATRX	546	broad.mit.edu	37	chrX	76937546	76937546	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaactatctcctttccctgTtgacttctcagcataatcag	10	14	4	13	0	3	1	2	1	2	0	6	1	4	1	2	0	2	2	2	0	3	5			TCGA-CQ-6224-01A-11D-1912-08	TCGA-CQ-6224-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	c03d51a0-8731-430d-a792-280e01629e8f	7c72a2dd-0b25-41a1-be66-a691196e57d0	g.chrX:76937546T>C	uc004ecp.3	-	9	3434	c.3202A>G	c.(3202-3204)ACA>GCA	p.T1068A	ATRX_uc004ecq.3_Missense_Mutation_p.T1030A|ATRX_uc004eco.3_Missense_Mutation_p.T853A|ATRX_uc004ecr.2_Missense_Mutation_p.T1000A|ATRX_uc010nlx.1_Missense_Mutation_p.T1039A|ATRX_uc010nly.1_Missense_Mutation_p.T1013A	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1068					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CCTTTCCCTGTTGACTTCTCA	0.338			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						32	151					0	0	0	0	C	76937546	C	C	76937546	3	2	106	1	0	0	0	0	1	0	0	0	1210	1725	60	5	4384	5	ATRX	23	76937546	Missense_Mutation	SNP	T	TCGA-CQ-6224-01A-11D-1912-08	6160655	76937546	78333014	86	19900											
PRAMEF18	391003	broad.mit.edu	37	chr1	13475012	13475012	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggttggagcagcggctcaGggcaggcaggatgaccctga	9	5	18	9	1	1	2	1	2	0	0	1	5	1	4	1	6	2	5	1	6	0	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:13475012G>T	uc009vnu.1	-	3	1164	c.1117C>A	c.(1117-1119)CTG>ATG	p.L373M		NM_001099850	NP_001093320	Q5VWM3	PRA18_HUMAN	PRAME family member 18	373											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CAGCGGCTCAGGGCAGGCAGG	0.572													6	179					0.00307968	0.00348408	1	0	T	13475012	T	T	13475012	3	4	107	1	0	0	0	0	1	0	0	0	12493	991	35	4	326	4	PRAMEF18	1	13475012	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08		13475012	235775609	1	19901											
CLCNKB	1188	broad.mit.edu	37	chr1	16375690	16375690	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggggcttctttgcggccaCctgcggggccttcatgttcc	3	11	14	13	2	2	0	1	0	1	0	3	1	3	0	4	5	2	2	4	5	0	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:16375690C>T	uc001axw.3	+	8	811	c.731C>T	c.(730-732)ACC>ATC	p.T244I	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.T244I|CLCNKB_uc001axy.3_Missense_Mutation_p.T75I	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	244	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TTTGCGGCCACCTGCGGGGCC	0.657													60	16					0	0	0	0	T	16375690	T	T	16375690	3	4	107	1	0	0	0	0	1	0	0	0	3485	507	18	4	905	4	CLCNKB	1	16375690	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	2900678	16375690	232874931	2	19902											
PTCH2	8643	broad.mit.edu	37	chr1	45293266	45293266	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtacctgagctgggcgctcaGgaaggcatgctccttggtgc	6	9	15	11	1	1	1	1	1	0	0	2	2	2	2	2	4	4	5	2	4	2	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:45293266G>A	uc010olf.1	-	15	2191	c.2179C>T	c.(2179-2181)CTG>TTG	p.L727L	PTCH2_uc010olg.1_Silent_p.L425L	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	727	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					TGGGCGCTCAGGAAGGCATGC	0.637									Basal_Cell_Nevus_syndrome				32	8					0	0	0	0	A	45293266	A	A	45293266	2	1	107	1	0	0	0	0	0	0	0	1	12793	991	35	4		4	PTCH2	1	45293266	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	28917576	45293266	203957355	3	19903											
WDR78	79819	broad.mit.edu	37	chr1	67292683	67292683	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatctgcagaacagcttaaaAatacatcatgacaaaatgga	20	8	6	7	0	2	2	1	1	1	1	2	3	2	3	0	1	4	2	0	1	8	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:67292683A>G	uc001dcx.2	-	15	2215	c.2159T>C	c.(2158-2160)TTT>TCT	p.F720S	WDR78_uc009waw.2_Missense_Mutation_p.F433S|WDR78_uc009wax.2_RNA	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	720	WD 4.									ovary(2)	2						ACAGCTTAAAAATACATCATG	0.313													31	40					0	0	0	0	G	67292683	G	G	67292683	3	3	107	1	0	0	0	0	1	0	0	0	17396	14	1	5	399	5	WDR78	1	67292683	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	21999417	67292683	181957938	4	19904											
WDR3	10885	broad.mit.edu	37	chr1	118497948	118497948	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcctttatagccttcagcttAtgtattagagatttttaaag	11	18	6	6	0	1	1	1	0	0	1	2	2	2	1	2	0	2	2	2	0	7	10			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:118497948A>T	uc010oxe.1	+	24	2486	c.2420A>T	c.(2419-2421)TAT>TTT	p.Y807F	WDR3_uc001ehi.2_Intron|SPAG17_uc001ehk.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	807						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		CCTTCAGCTTATGTATTAGAG	0.358													23	3					0	0	0	0	T	118497948	T	T	118497948	3	4	107	1	0	0	0	0	1	0	0	0	17353	449	16	5	2510	5	WDR3	1	118497948	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	51205265	118497948	130752673	5	19905											
WARS2	10352	broad.mit.edu	37	chr1	119619197	119619197	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggaggattcctgtaggttGaatgccggaaaatactcgct	10	11	13	7	2	0	1	0	1	0	0	2	4	1	4	2	4	2	3	2	4	5	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:119619197G>T	uc001ehn.2	-	2	152	c.124C>A	c.(124-126)CAA>AAA	p.Q42K	WARS2_uc010oxf.1_5'UTR|WARS2_uc001ehm.2_Missense_Mutation_p.Q42K|WARS2_uc010oxg.1_Missense_Mutation_p.Q42K|WARS2_uc010oxh.1_Missense_Mutation_p.Q42K|WARS2_uc010oxi.1_5'UTR	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	42					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	CCTGTAGGTTGAATGCCGGAA	0.438													87	22					3.99893e-49	5.11862e-49	1	0	T	119619197	T	T	119619197	3	4	107	1	0	0	0	0	1	0	0	0	17318	1299	45	2	1007	2	WARS2	1	119619197	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	1121249	119619197	129631424	6	19906											
LOC200030	200030	broad.mit.edu	37	chr1	148017570	148017570	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgtgctgctgtaagacttgTacgaggccaacatttcagga	11	11	11	8	1	1	1	1	0	0	1	1	3	1	2	1	2	4	4	1	2	3	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:148017570T>A	uc001eqf.2	-	12	1768	c.1733A>T	c.(1732-1734)TAC>TTC	p.Y578F	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc009wkf.1_RNA|NBPF14_uc001eqq.2_Missense_Mutation_p.Y238F|NBPF14_uc001eqs.1_Missense_Mutation_p.Y117F	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	578	NBPF 3.					cytoplasm					0						GTAAGACTTGTACGAGGCCAA	0.478													8	401					0	0	0	0	A	148017570	A	A	148017570	3	1	107	1	0	0	0	0	1	0	0	0	8917	1638	57	5		5	LOC200030	1	148017570	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	28398373	148017570	101233051	7	19907											
LCE1E	353135	broad.mit.edu	37	chr1	152759999	152759999	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagctctgggggaggtggctGctgcctgagccaccacaggc	6	6	16	13	0	1	1	0	1	1	0	1	2	1	2	3	5	4	3	3	5	0	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:152759999G>C	uc001fan.2	+	2	277	c.224G>C	c.(223-225)TGC>TCC	p.C75S		NM_178353	NP_848130	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	75	Cys-rich.				keratinization						0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGGTGGCTGCTGCCTGAGC	0.687													4	117					0	0	0	0	C	152759999	C	C	152759999	3	2	107	1	0	0	0	0	1	0	0	0	8703	1319	46	4	226	4	LCE1E	1	152759999	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	4742429	152759999	96490622	8	19908											
SMG5	23381	broad.mit.edu	37	chr1	156233237	156233237	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccgaagccagtccaggaaGactttcacagcaggaagcag	13	5	12	11	1	1	1	1	0	0	1	3	4	3	3	3	2	3	2	3	2	3	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:156233237G>C	uc001foc.3	-	13	2129	c.1980C>G	c.(1978-1980)GTC>GTG	p.V660V	SMG5_uc009wrv.2_Silent_p.V145V	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	660					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					AGTCCAGGAAGACTTTCACAG	0.597													52	67					0	0	0	0	C	156233237	C	C	156233237	2	2	107	1	0	0	0	0	0	0	0	1	14860	929	33	2		2	SMG5	1	156233237	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	3473238	156233237	93017384	9	19909											
PVRL4	81607	broad.mit.edu	37	chr1	161049448	161049448	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgacccggcactcgtacTcgccctcatccgcctgcact	5	9	8	19	4	1	1	1	1	0	0	4	1	2	1	4	1	3	4	4	1	1	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:161049448T>C	uc001fxo.2	-	2	670	c.371A>G	c.(370-372)GAG>GGG	p.E124G		NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	124	Ig-like V-type 1.|Extracellular (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			GCACTCGTACTCGCCCTCATC	0.716													6	13					0	0	0	0	C	161049448	C	C	161049448	3	2	107	1	0	0	0	0	1	0	0	0	12907	1551	54	5	1193	5	PVRL4	1	161049448	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	4816211	161049448	88201173	10	19910											
KIF21B	23046	broad.mit.edu	37	chr1	200956237	200956237	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atctcaacgagggaggccagGgacttggtgatgttcttggt	8	11	15	7	1	2	1	1	1	2	0	3	4	2	3	1	5	1	1	1	5	1	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:200956237G>A	uc001gvs.1	-	25	3818	c.3501C>T	c.(3499-3501)TCC>TCT	p.S1167S	KIF21B_uc001gvr.1_Silent_p.S1167S|KIF21B_uc009wzl.1_Silent_p.S1167S|KIF21B_uc010ppn.1_Silent_p.S1167S	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1167					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGGAGGCCAGGGACTTGGTGA	0.592													9	178					0	0	0	0	A	200956237	A	A	200956237	2	1	107	1	0	0	0	0	0	0	0	1	8328	1219	43	4		4	KIF21B	1	200956237	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	39906789	200956237	48294384	11	19911											
MYOG	4656	broad.mit.edu	37	chr1	203054717	203054717	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctcgatgtactggatggCactgcgcaggatctccacct	7	9	12	13	3	1	0	0	0	1	0	3	3	1	2	2	3	2	4	2	3	1	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:203054717C>T	uc001gzd.2	-	1	661	c.373G>A	c.(373-375)GCC>ACC	p.A125T		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	125	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2						TACTGGATGGCACTGCGCAGG	0.672													10	55					0	0	0	0	T	203054717	T	T	203054717	3	4	107	1	0	0	0	0	1	0	0	0	10143	710	25	4	313	4	MYOG	1	203054717	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	2098480	203054717	46195904	12	19912											
CABC1	56997	broad.mit.edu	37	chr1	227174248	227174250	+	In_Frame_Del	DEL	AGA	-	-																															tggcactcagagcaccaccgAgaagatccacaacctgattc																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:227174248_227174250delAGA	uc001hqm.1	+	20	5173_5175	c.1754_1756delAGA	c.(1753-1758)GAGAAG>GAG	p.K586del	CABC1_uc001hqn.1_In_Frame_Del_p.K586del|CABC1_uc009xeq.1_In_Frame_Del_p.K534del|CABC1_uc010pvq.1_In_Frame_Del_p.K307del|CABC1_uc010pvr.1_In_Frame_Del_p.K260del|CABC1_uc001hqo.1_In_Frame_Del_p.K307del|CABC1_uc009xer.1_In_Frame_Del_p.K102del	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	586					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				AGCACCACCGAGAAGATCCACAA	0.591													---	---	---								-	227174250	-	-	227174248	7	5	107	1	0	1	0	1	0	0	0	0	2539	304	11	0	1808	0	CABC1	1	227174248	In_Frame_Del	DEL	AGA	TCGA-CQ-6225-01A-11D-1912-08	24119531	227174248	22076373	13	19913											
SIPA1L2	57568	broad.mit.edu	37	chr1	232650590	232650590	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcggcatcaatgtcactgaTagtgacatcactattgctcc	10	13	7	11	1	3	2	3	2	0	0	5	2	4	2	1	1	1	2	1	1	3	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr1:232650590T>C	uc001hvg.2	-	1	654	c.496A>G	c.(496-498)ATC>GTC	p.I166V		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	166					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				ATGTCACTGATAGTGACATCA	0.502													130	19					0	0	0	0	C	232650590	C	C	232650590	3	2	107	1	0	0	0	0	1	0	0	0	14395	1406	49	5	4756	5	SIPA1L2	1	232650590	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	5476342	232650590	16600031	14	19914											
RRM2	6241	broad.mit.edu	37	chr2	10267005	10267006	+	Frame_Shift_Ins	INS	-	T	T																															cgtatgtgcctactagggaaINStttctcttcaatgccattga																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:10267005_10267006insT	uc002rah.2	+	6	764_765	c.573_574insT	c.(571-576)GAATTTfs	p.E191fs		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	191_192					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		CTACTAGGGAATTTCTCTTCAA	0.465													---	---	---								T	10267006	T	T	10267005	7	5	107	1	0	1	1	0	0	0	0	0	13747	98	4	0	775	0	RRM2	2	10267005	Frame_Shift_Ins	INS	-	TCGA-CQ-6225-01A-11D-1912-08		10267005	232932368	15	19915											
ATP6V1C2	245973	broad.mit.edu	37	chr2	10908907	10908908	+	Frame_Shift_Del	DEL	AA	-	-																															gcctacaacactctgaagacAaacctggagaacctggaaaa																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:10908907_10908908delAA	uc002ras.2	+	6	550_551	c.441_442delAA	c.(439-444)ACAAACfs	p.T147fs	ATP6V1C2_uc002rat.2_Frame_Shift_Del_p.T147fs	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	vacuolar H+ ATPase C2 isoform a	147_148					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		CTCTGAAGACAAACCTGGAGAA	0.569													---	---	---								-	10908908	-	-	10908907	7	5	107	1	0	1	0	1	0	0	0	0	1183	117	5	0	459	0	ATP6V1C2	2	10908907	Frame_Shift_Del	DEL	AA	TCGA-CQ-6225-01A-11D-1912-08	641902	10908907	232290466	16	19916											
CRIM1	51232	broad.mit.edu	37	chr2	36691694	36691694	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagatgcgagtgtctctctgGcttatgtggtttccccgtgt	4	15	12	10	2	2	1	0	0	2	1	4	2	3	1	2	2	1	2	2	2	1	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:36691694G>C	uc002rpd.2	+	5	926	c.887G>C	c.(886-888)GGC>GCC	p.G296A		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	296	Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				TGTCTCTCTGGCTTATGTGGT	0.493													67	106					0	0	0	0	C	36691694	C	C	36691694	3	2	107	1	0	0	0	0	1	0	0	0	3888	1203	42	4	905	4	CRIM1	2	36691694	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	25782787	36691694	206507679	17	19917											
PRKD3	23683	broad.mit.edu	37	chr2	37520323	37520323	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcatgtatttcatctgctGaggtaatcagctgcaaaatg	11	14	8	8	0	4	1	3	1	1	0	4	1	4	1	0	1	3	5	0	1	4	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:37520323G>A	uc002rqd.2	-	2	935	c.380C>T	c.(379-381)TCA>TTA	p.S127L	PRKD3_uc002rqf.1_Missense_Mutation_p.S127L	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	127					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				TTCATCTGCTGAGGTAATCAG	0.408													23	60					0	0	0	0	A	37520323	A	A	37520323	3	1	107	1	0	0	0	0	1	0	0	0	12582	1294	45	2	2360	2	PRKD3	2	37520323	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	828629	37520323	205679050	18	19918											
NRXN1	9378	broad.mit.edu	37	chr2	50149151	50149151	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgcactgctgggttgtttCtcctttacaacagccccatt	6	15	7	13	1	1	0	0	0	1	0	3	0	1	0	3	1	4	4	3	1	2	6			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:50149151C>A	uc010fbp.2	-	6	2067	c.1260G>T	c.(1258-1260)GAG>GAT	p.E420D	NRXN1_uc002rxb.3_Missense_Mutation_p.E1154D|NRXN1_uc010fbq.2_Missense_Mutation_p.E1525D|NRXN1_uc002rxe.3_Missense_Mutation_p.E1455D|NRXN1_uc010yon.1_Missense_Mutation_p.E120D|NRXN1_uc002rxa.3_Missense_Mutation_p.E117D	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	420	Cytoplasmic (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TGGGTTGTTTCTCCTTTACAA	0.413													33	47					8.16721e-17	9.88894e-17	1	0	A	50149151	A	A	50149151	3	1	107	1	0	0	0	0	1	0	0	0	10719	912	32	2	72	2	NRXN1	2	50149151	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	12628828	50149151	193050222	19	19919											
SPTBN1	6711	broad.mit.edu	37	chr2	54891603	54891603	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctagatggcagaaacggTggacacaagcgaaatggtca	14	6	12	9	2	1	2	1	0	0	2	2	4	2	3	1	4	2	1	1	4	4	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:54891603T>G	uc002rxu.2	+	33	6683	c.6434T>G	c.(6433-6435)GTG>GGG	p.V2145G	SPTBN1_uc010you.1_Missense_Mutation_p.V135G	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	2145					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GCAGAAACGGTGGACACAAGC	0.562													42	219					0	0	0	0	G	54891603	G	G	54891603	3	3	107	1	0	0	0	0	1	0	0	0	15185	1696	59	5	6760	5	SPTBN1	2	54891603	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	4742452	54891603	188307770	20	19920											
DYSF	8291	broad.mit.edu	37	chr2	71780158	71780158	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagtaccttaggaggcgCaagtactccctgtttgcggc	9	9	12	11	2	0	1	0	0	0	1	1	2	1	2	2	3	3	4	2	3	5	4	rs34644852		TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:71780158C>G	uc002sie.2	+	20	2146	c.1770C>G	c.(1768-1770)CGC>CGG	p.R590R	DYSF_uc010feg.2_Silent_p.R621R|DYSF_uc010feh.2_Silent_p.R576R|DYSF_uc002sig.3_Silent_p.R576R|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.R590R|DYSF_uc010fef.2_Silent_p.R607R|DYSF_uc010fei.2_Silent_p.R607R|DYSF_uc010fek.2_Silent_p.R608R|DYSF_uc010fej.2_Silent_p.R577R|DYSF_uc010fel.2_Silent_p.R577R|DYSF_uc010feo.2_Silent_p.R622R|DYSF_uc010fem.2_Silent_p.R591R|DYSF_uc010fen.2_Silent_p.R608R|DYSF_uc002sif.2_Silent_p.R591R	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	590	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TTAGGAGGCGCAAGTACTCCC	0.567													3	55					0	0	0	0	G	71780158	G	G	71780158	2	3	107	1	0	0	0	0	0	0	0	1	4881	697	25	4		4	DYSF	2	71780158	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	16888555	71780158	171419215	21	19921											
C1QL2	165257	broad.mit.edu	37	chr2	119915824	119915824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagcagcagcggcacggCgatgagcagcccgagcgcca	9	2	15	15	5	0	1	0	1	0	0	0	3	0	1	2	2	7	5	2	2	0	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:119915824C>T	uc002tlo.2	-	1	648	c.22G>A	c.(22-24)GCC>ACC	p.A8T		NM_182528	NP_872334	Q7Z5L3	C1QL2_HUMAN	complement component 1, q subcomponent-like 2	8						collagen				pancreas(1)	1						AGCGGCACGGCGATGAGCAGC	0.741										HNSCC(49;0.14)			3	10					0	0	0	0	T	119915824	T	T	119915824	3	4	107	1	0	0	0	0	1	0	0	0	1968	768	27	1	849	1	C1QL2	2	119915824	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	48135666	119915824	123283549	22	19922											
ACMSD	130013	broad.mit.edu	37	chr2	135596266	135596266	+	Frame_Shift_Del	DEL	T	-	-																															tgtggagatgaaaattgacaTccatagtcatattctaccaa																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:135596266delT	uc002ttz.2	+	1	81	c.14delT	c.(13-15)ATCfs	p.I5fs	ACMSD_uc002tua.2_5'UTR	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	5					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		AAAATTGACATCCATAGTCAT	0.343													---	---	---								-	135596266	-	-	135596266	7	5	107	1	0	1	0	1	0	0	0	0	144	1435	50	0	16	0	ACMSD	2	135596266	Frame_Shift_Del	DEL	T	TCGA-CQ-6225-01A-11D-1912-08	15680442	135596266	107603107	23	19923											
LRP1B	53353	broad.mit.edu	37	chr2	141359174	141359174	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtacagtgtatcccaggcTctgtgataggcaagtccttc	9	11	10	11	0	1	1	0	1	1	0	4	1	3	1	2	2	1	4	2	2	4	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:141359174T>A	uc002tvj.1	-	42	7806	c.6834A>T	c.(6832-6834)AGA>AGT	p.R2278S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2278	Extracellular (Potential).|LDL-receptor class B 23.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATCCCAGGCTCTGTGATAGG	0.448										TSP Lung(27;0.18)			6	47					0	0	0	0	A	141359174	A	A	141359174	3	1	107	1	0	0	0	0	1	0	0	0	9005	1548	54	5	7165	5	LRP1B	2	141359174	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	5762908	141359174	101840199	24	19924											
TNFAIP6	7130	broad.mit.edu	37	chr2	152226607	152226607	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcttcccaaatgagtacgaAgataaccaaatctgctactg	14	9	8	10	1	1	2	0	1	1	1	2	3	2	2	2	1	4	3	2	1	6	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:152226607A>T	uc002txk.2	+	4	544	c.468A>T	c.(466-468)GAA>GAT	p.E156D		NM_007115	NP_009046	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	156	CUB.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		ATGAGTACGAAGATAACCAAA	0.398													64	69					0	0	0	0	T	152226607	T	T	152226607	3	4	107	1	0	0	0	0	1	0	0	0	16341	69	3	5	482	5	TNFAIP6	2	152226607	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	10867433	152226607	90972766	25	19925											
GALNT5	11227	broad.mit.edu	37	chr2	158162305	158162305	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcatttccattgaaaacacTacagtcattctggaagactg	13	12	7	9	0	2	2	1	1	1	1	3	3	3	3	1	1	3	1	1	1	4	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:158162305T>C	uc002tzg.2	+	8	2739	c.2484T>C	c.(2482-2484)ACT>ACC	p.T828T	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	828	Lumenal (Potential).|Ricin B-type lectin.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						TTGAAAACACTACAGTCATTC	0.358													6	46					0	0	0	0	C	158162305	C	C	158162305	2	2	107	1	0	0	0	0	0	0	0	1	6251	1509	53	5		5	GALNT5	2	158162305	Silent	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	5935698	158162305	85037068	26	19926											
MARCH7	64844	broad.mit.edu	37	chr2	160619499	160619499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaatgaaccaagcacacgtGtccgagtaagtaataatgaa	18	7	8	8	2	0	2	0	2	0	0	1	3	1	2	2	0	2	3	2	0	7	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:160619499G>A	uc002uax.2	+	8	2124	c.2002G>A	c.(2002-2004)GTC>ATC	p.V668I	MARCH7_uc010foq.2_Missense_Mutation_p.V668I|MARCH7_uc010zcn.1_Missense_Mutation_p.V612I|MARCH7_uc010for.2_Missense_Mutation_p.V630I|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	668							ligase activity|zinc ion binding				0						AAGCACACGTGTCCGAGTAAG	0.413													5	41					0	0	0	0	A	160619499	A	A	160619499	3	1	107	1	0	0	0	0	1	0	0	0	9359	1377	48	4	2028	4	MARCH7	2	160619499	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	2457194	160619499	82579874	27	19927											
SLC4A10	57282	broad.mit.edu	37	chr2	162661031	162661031	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcgacgtcacaggcatcGtggtcataaacacagaaaga	15	6	9	11	3	2	2	2	0	0	2	4	3	2	2	1	2	1	1	1	2	3	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:162661031G>A	uc002ubx.3	+	3	387	c.203G>A	c.(202-204)CGT>CAT	p.R68H	SLC4A10_uc010fpa.1_Missense_Mutation_p.R80H|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.R68H|SLC4A10_uc010zcs.1_Missense_Mutation_p.R79H	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	68	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CACAGGCATCGTGGTCATAAA	0.418													22	21					0	0	0	0	A	162661031	A	A	162661031	3	1	107	1	0	0	0	0	1	0	0	0	14715	1145	40	1	298	1	SLC4A10	2	162661031	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	2041532	162661031	80538342	28	19928											
KCNH7	90134	broad.mit.edu	37	chr2	163280005	163280005	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccgagtatagtctttggatAattgcagatacattcccaaa	13	12	7	9	1	1	1	0	0	1	1	2	3	2	2	2	1	2	2	2	1	5	7			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:163280005A>T	uc002uch.1	-	9	2207	c.1995T>A	c.(1993-1995)ATT>ATA	p.I665I	KCNH7_uc002uci.2_Silent_p.I658I	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	665	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	GTCTTTGGATAATTGCAGATA	0.418													51	57					0	0	0	0	T	163280005	T	T	163280005	2	4	107	1	0	0	0	0	0	0	0	1	8076	358	13	5		5	KCNH7	2	163280005	Silent	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	618974	163280005	79919368	29	19929											
TTN	7273	broad.mit.edu	37	chr2	179587427	179587427	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagaagaagcagttcctataCtattttctgctttgcatgtg	10	16	8	7	0	1	2	0	0	1	2	2	2	2	2	1	0	4	4	1	0	6	8			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:179587427C>G	uc010zfg.1	-	73	18691	c.18467G>C	c.(18466-18468)AGT>ACT	p.S6156T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S2817T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7083							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTCCTATACTATTTTCTGC	0.328													14	14					0	0	0	0	G	179587427	G	G	179587427	3	3	107	1	0	0	0	0	1	0	0	0	16803	565	20	4	82478	4	TTN	2	179587427	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	16307422	179587427	63611946	30	19930											
ZNF804A	91752	broad.mit.edu	37	chr2	185800683	185800683	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taccactgttgctgaagatcCagaaagtgcaaataattata	16	11	7	7	0	0	3	0	1	0	2	1	3	1	3	2	0	3	3	2	0	7	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:185800683C>A	uc002uph.2	+	4	1154	c.560C>A	c.(559-561)CCA>CAA	p.P187Q		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	187						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GCTGAAGATCCAGAAAGTGCA	0.368													20	28					1.15919e-05	1.34538e-05	1	0	A	185800683	A	A	185800683	3	1	107	1	0	0	0	0	1	0	0	0	18237	594	21	4	574	4	ZNF804A	2	185800683	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	6213256	185800683	57398690	31	19931											
ZNF804A	91752	broad.mit.edu	37	chr2	185803540	185803540	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaaatcccagctctcacCagaacctcattacctcagct	11	9	3	18	0	3	1	3	0	1	1	6	1	5	1	5	0	4	2	5	0	3	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:185803540C>G	uc002uph.2	+	4	4011	c.3417C>G	c.(3415-3417)ACC>ACG	p.T1139T		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1139						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CAGCTCTCACCAGAACCTCAT	0.393													43	66					0	0	0	0	G	185803540	G	G	185803540	2	3	107	1	0	0	0	0	0	0	0	1	18237	581	21	4		4	ZNF804A	2	185803540	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	2857	185803540	57395833	32	19932											
PTH2R	5746	broad.mit.edu	37	chr2	209308082	209308082	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctctccgtagacgattgcaTtgcactaggaactatatcca	11	12	7	11	2	1	1	0	0	1	1	4	3	3	2	2	1	3	3	2	1	5	6			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr2:209308082T>C	uc002vdb.2	+	6	732	c.519T>C	c.(517-519)CAT>CAC	p.H173H	PTH2R_uc010zjb.1_Silent_p.H184H	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	173	Cytoplasmic (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		GACGATTGCATTGCACTAGGA	0.423													19	6					0	0	0	0	C	209308082	C	C	209308082	2	2	107	1	0	0	0	0	0	0	0	1	12823	1490	52	5		5	PTH2R	2	209308082	Silent	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	23504542	209308082	33891291	33	19933											
TOMM70A	9868	broad.mit.edu	37	chr3	100093900	100093900	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacatctgcattctgaggatCgatgtcagcagccatgttaa	12	11	9	9	1	3	1	1	1	2	0	4	3	3	2	1	1	4	3	1	1	2	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:100093900C>T	uc003dtw.2	-	7	1621	c.1189G>A	c.(1189-1191)GAT>AAT	p.D397N		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	397	Cytoplasmic (Potential).|TPR 5.				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						TTCTGAGGATCGATGTCAGCA	0.443													47	84					0	0	0	0	T	100093900	T	T	100093900	3	4	107	1	0	0	0	0	1	0	0	0	16429	884	31	1	661	1	TOMM70A	3	100093900	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08		100093900	97928530	34	19934											
LNP1	348801	broad.mit.edu	37	chr3	100170729	100170729	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggaagatcccattccaaaaTtgagaaattttcagagtcct	15	11	7	8	0	1	3	1	1	0	3	4	5	4	4	3	1	0	0	3	1	4	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:100170729T>C	uc003dtx.3	+	3	1603	c.323T>C	c.(322-324)ATT>ACT	p.I108T	LNP1_uc003dty.3_RNA|LNP1_uc011bhb.1_RNA	NM_001085451	NP_001078920	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	108											0						CATTCCAAAATTGAGAAATTT	0.428													82	39					0	0	0	0	C	100170729	C	C	100170729	3	2	107	1	0	0	0	0	1	0	0	0	8905	1493	52	5	329	5	LNP1	3	100170729	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	76829	100170729	97851701	35	19935											
TMEM45A	55076	broad.mit.edu	37	chr3	100275788	100275788	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgtgtccttaaccaagttAatgttgtcaaatgccttatt	10	16	6	9	0	1	0	1	0	0	0	2	0	2	0	4	0	2	2	4	0	5	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:100275788A>G	uc003dtz.1	+	3	688	c.375A>G	c.(373-375)TTA>TTG	p.L125L	TMEM45A_uc003dua.1_Silent_p.L141L	NM_018004	NP_060474	Q9NWC5	TM45A_HUMAN	transmembrane protein 45A	125						integral to membrane				skin(2)|ovary(1)	3						TAACCAAGTTAATGTTGTCAA	0.378													12	240					0	0	0	0	G	100275788	G	G	100275788	2	3	107	1	0	0	0	0	0	0	0	1	16235	359	13	5		5	TMEM45A	3	100275788	Silent	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	105059	100275788	97746642	36	19936											
SR140	23350	broad.mit.edu	37	chr3	142740399	142740399	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggaaacattaatccacaggTaatattaagtaagatgaatg	18	11	8	4	0	0	2	0	1	0	1	1	3	1	3	1	2	1	2	1	2	7	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:142740399T>C	uc003evh.1	+	10	951	c.852_splice	c.e10+2	p.Q284_splice	SR140_uc003evi.1_Splice_Site|SR140_uc011bnj.1_Splice_Site_p.Q284_splice|SR140_uc003evj.1_Splice_Site|SR140_uc003evk.1_Splice_Site_p.Q283_splice	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein						RNA processing	nucleus	nucleotide binding|RNA binding				0						AATCCACAGGTAATATTAAGT	0.343													8	37					0	0	0	0	C	142740399	C	C	142740399	5	2	107	1	0	0	0	0	0	0	1	0	15197	1652	57	5	892	5	SR140	3	142740399	Splice_Site	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	42464611	142740399	55282031	37	19937											
SUCNR1	56670	broad.mit.edu	37	chr3	151597696	151597696	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acgacatgctggggatcatgGtatgtttagagacacaaaag	14	9	12	6	1	1	1	1	0	0	1	1	4	1	2	0	3	1	3	0	3	4	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:151597696G>A	uc003ezf.1	+	2	114	c.15_splice	c.e2+1	p.M5_splice		NM_033050	NP_149039	Q9BXA5	SUCR1_HUMAN	succinate receptor 1							integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)		Succinic acid(DB00139)	GGGGATCATGGTATGTTTAGA	0.224													28	65					0	0	0	0	A	151597696	A	A	151597696	5	1	107	1	0	0	0	0	0	0	1	0	15432	1275	44	4	18	4	SUCNR1	3	151597696	Splice_Site	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	8857297	151597696	46424734	38	19938											
MFSD1	64747	broad.mit.edu	37	chr3	158539427	158539427	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggattttcttcccaggcagCaagtgcaattaacaggtatt	11	13	9	8	0	1	0	0	0	1	0	2	1	2	1	1	3	3	4	1	3	4	6			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:158539427C>A	uc003fcl.1	+	10	935	c.905C>A	c.(904-906)GCA>GAA	p.A302E	MFSD1_uc003fcm.1_RNA|MFSD1_uc003fcn.1_Missense_Mutation_p.A205E|MFSD1_uc011bow.1_Missense_Mutation_p.A263E|MFSD1_uc011box.1_Missense_Mutation_p.A229E	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	302					transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TCCCAGGCAGCAAGTGCAATT	0.294													12	129					1.5739e-10	1.88531e-10	1	0	A	158539427	A	A	158539427	3	1	107	1	0	0	0	0	1	0	0	0	9580	710	25	4	1090	4	MFSD1	3	158539427	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	6941731	158539427	39483003	39	19939											
NLGN1	22871	broad.mit.edu	37	chr3	173322668	173322668	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccccaccaacaggggaacgtCgttttcagcctccagaacca	11	6	8	16	2	1	1	1	0	0	1	3	2	2	2	6	2	4	1	6	2	3	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:173322668C>G	uc003fio.1	+	3	703	c.280C>G	c.(280-282)CGT>GGT	p.R94G	NLGN1_uc010hww.1_Missense_Mutation_p.R94G|NLGN1_uc003fip.1_Missense_Mutation_p.R94G	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	94	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			AGGGGAACGTCGTTTTCAGCC	0.453													5	251					0	0	0	0	G	173322668	G	G	173322668	3	3	107	1	0	0	0	0	1	0	0	0	10515	884	31	3	282	3	NLGN1	3	173322668	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	14783241	173322668	24699762	40	19940											
KCNMB2	10242	broad.mit.edu	37	chr3	178546115	178546115	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgacttcttccggggaaaAgctcctcctctaccacacag	9	9	7	16	1	2	1	0	1	2	0	5	2	5	2	5	2	2	1	5	2	3	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:178546115A>G	uc003fjd.2	+	4	720	c.377A>G	c.(376-378)AAG>AGG	p.K126R	uc003fjb.1_Intron|uc003fjc.1_Intron|KCNMB2_uc003fje.2_Missense_Mutation_p.K126R|KCNMB2_uc003fjf.2_Missense_Mutation_p.K126R|KCNMB2_uc011bqa.1_Intron|KCNMB2_uc011bqb.1_Intron	NM_181361	NP_852006	Q9Y691	KCMB2_HUMAN	calcium-activated potassium channel beta 2	126	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(1)	1	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			TCCGGGGAAAAGCTCCTCCTC	0.478													22	41					0	0	0	0	G	178546115	G	G	178546115	3	3	107	1	0	0	0	0	1	0	0	0	8114	72	3	5	387	5	KCNMB2	3	178546115	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	5223447	178546115	19476315	41	19941											
PEX5L	51555	broad.mit.edu	37	chr3	179615940	179615940	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgcccacctgtgatgtcAtagtaaggaggggcttttct	7	13	12	9	0	3	1	1	1	2	0	3	2	3	2	2	3	1	2	2	3	2	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:179615940A>C	uc003fki.1	-	3	318	c.188T>G	c.(187-189)ATG>AGG	p.M63R	PEX5L_uc011bqd.1_Missense_Mutation_p.M20R|PEX5L_uc011bqe.1_Intron|PEX5L_uc011bqf.1_Missense_Mutation_p.M20R|PEX5L_uc003fkj.1_Intron|PEX5L_uc010hxd.1_Missense_Mutation_p.M61R|PEX5L_uc011bqg.1_Missense_Mutation_p.M39R|PEX5L_uc011bqh.1_Intron	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	63					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CTGTGATGTCATAGTAAGGAG	0.428													9	123					0	0	0	0	C	179615940	C	C	179615940	3	2	107	1	0	0	0	0	1	0	0	0	11804	217	8	5	1744	5	PEX5L	3	179615940	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	1069825	179615940	18406490	42	19942											
HTR3D	200909	broad.mit.edu	37	chr3	183756634	183756634	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggcccagcgggaacacgaGgcccagaagcagcactcggt	11	2	15	13	3	0	1	0	0	0	1	1	3	0	2	2	4	4	2	2	4	2	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:183756634G>C	uc011bqv.1	+	8	1236	c.1236G>C	c.(1234-1236)GAG>GAC	p.E412D	HTR3D_uc003fmj.2_Missense_Mutation_p.E237D|HTR3D_uc011bqu.1_Missense_Mutation_p.E362D|HTR3D_uc010hxp.2_Missense_Mutation_p.E191D	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	412	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GGGAACACGAGGCCCAGAAGC	0.637													42	115					0	0	0	0	C	183756634	C	C	183756634	3	2	107	1	0	0	0	0	1	0	0	0	7486	991	35	4	1436	4	HTR3D	3	183756634	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	4140694	183756634	14265796	43	19943											
HRG	3273	broad.mit.edu	37	chr3	186386805	186386805	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggaaatactggaatgacTgtgagccacctgattccaga	13	8	10	10	0	0	4	0	3	0	1	1	6	1	6	4	2	2	0	4	2	3	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr3:186386805T>C	uc003fqq.2	+	2	288	c.265T>C	c.(265-267)TGT>CGT	p.C89R		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	89	Cystatin 1.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CTGGAATGACTGTGAGCCACC	0.413													4	137					0	0	0	0	C	186386805	C	C	186386805	3	2	107	1	0	0	0	0	1	0	0	0	7393	1580	55	5	271	5	HRG	3	186386805	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	2630171	186386805	11635625	44	19944											
RFC1	5981	broad.mit.edu	37	chr4	39290414	39290414	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttttccttttccttttctGggctccttatctttttctgg	1	24	5	11	0	3	0	0	0	3	0	6	0	6	0	3	2	0	1	3	2	1	9			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr4:39290414G>A	uc003gty.1	-	25	3548	c.3414C>T	c.(3412-3414)CCC>CCT	p.P1138P	RFC1_uc003gtx.1_Silent_p.P1137P	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	1138					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						TTCCTTTTCTGGGCTCCTTAT	0.378													26	12					0	0	0	0	A	39290414	A	A	39290414	2	1	107	1	0	0	0	0	0	0	0	1	13309	1335	47	4		4	RFC1	4	39290414	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08		39290414	151863862	45	19945											
ATP8A1	10396	broad.mit.edu	37	chr4	42524198	42524198	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttcaatcaactcataactCtcttcgagtttgagtagcct	10	16	5	10	1	4	1	3	1	1	0	6	2	4	1	1	0	3	2	1	0	4	6			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr4:42524198C>G	uc003gwr.2	-	22	2158	c.1926G>C	c.(1924-1926)GAG>GAC	p.E642D	ATP8A1_uc003gws.2_Missense_Mutation_p.E627D	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	642	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	ACTCATAACTCTCTTCGAGTT	0.433													87	13					0	0	0	0	G	42524198	G	G	42524198	3	3	107	1	0	0	0	0	1	0	0	0	1194	912	32	2	1632	2	ATP8A1	4	42524198	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	3233784	42524198	148630078	46	19946											
NFXL1	152518	broad.mit.edu	37	chr4	47853112	47853112	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtattttgtttggttacCtgttgtcttcgtttttcttc	2	24	9	6	1	2	0	0	0	2	0	4	0	2	0	1	2	1	5	1	2	2	10			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr4:47853112C>A	uc010igh.2	-	22	2739	c.2562G>T	c.(2560-2562)CAG>CAT	p.Q854H	NFXL1_uc003gxo.2_Missense_Mutation_p.Q179H|NFXL1_uc003gxp.2_Missense_Mutation_p.Q854H|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Missense_Mutation_p.Q854H	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	854	Potential.					integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GTTTGGTTACCTGTTGTCTTC	0.353													8	21					0.000978159	0.0011179	1	0	A	47853112	A	A	47853112	3	1	107	1	0	0	0	0	1	0	0	0	10442	695	24	4	181	4	NFXL1	4	47853112	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	5328914	47853112	143301164	47	19947											
POLR2B	5431	broad.mit.edu	37	chr4	57852522	57852522	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atatttttgtttttacagatAtgcaatatgatgaggatgat	13	18	8	2	0	0	4	0	3	0	1	0	5	0	5	0	1	2	2	0	1	5	8			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr4:57852522A>G	uc003hcl.1	+	2	65	c.22A>G	c.(22-24)ATG>GTG	p.M8V	POLR2B_uc011cae.1_Missense_Mutation_p.M1V|POLR2B_uc011caf.1_Translation_Start_Site	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	8					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					TTTTACAGATATGCAATATGA	0.358													38	23					0	0	0	0	G	57852522	G	G	57852522	3	3	107	1	0	0	0	0	1	0	0	0	12270	449	16	5	28	5	POLR2B	4	57852522	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	9999410	57852522	133301754	48	19948											
TECRL	253017	broad.mit.edu	37	chr4	65175550	65175550	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaagcatcctcaccattatCaaatttttcaaaggtgtgtg	13	13	6	9	0	3	0	3	0	0	0	4	0	4	0	2	1	1	1	2	1	4	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr4:65175550C>T	uc003hcv.2	-	6	760	c.651G>A	c.(649-651)TTG>TTA	p.L217L	TECRL_uc003hcw.2_Silent_p.L217L	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	217	Helical; (Potential).				lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						TCACCATTATCAAATTTTTCA	0.338													18	56					0	0	0	0	T	65175550	T	T	65175550	2	4	107	1	0	0	0	0	0	0	0	1	15812	825	29	2		2	TECRL	4	65175550	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	7323028	65175550	125978726	49	19949											
C5orf38	153571	broad.mit.edu	37	chr5	2752514	2752514	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgcctacccctcgcggtcCactccgcccagcatggacct	5	7	9	20	4	0	0	0	0	0	0	4	1	2	1	7	2	2	1	7	2	1	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:2752514C>T	uc003jdc.2	+	1	253	c.136C>T	c.(136-138)CAC>TAC	p.H46Y	C5orf38_uc011cmg.1_Missense_Mutation_p.H46Y|C5orf38_uc011cmh.1_RNA|C5orf38_uc011cmi.1_RNA|C5orf38_uc011cmj.1_RNA	NM_178569	NP_848664	Q86SI9	CEI_HUMAN	hypothetical protein LOC153571 precursor	46						extracellular region					0				GBM - Glioblastoma multiforme(108;0.205)		CCTCGCGGTCCACTCCGCCCA	0.701													9	4					0	0	0	0	T	2752514	T	T	2752514	3	4	107	1	0	0	0	0	1	0	0	0	2306	594	21	4	138	4	C5orf38	5	2752514	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08		2752514	178162746	50	19950											
PRDM9	56979	broad.mit.edu	37	chr5	23526667	23526667	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggggagctgtagagtgggAaaaagaataatggaagaaga	18	6	16	1	0	0	4	0	0	0	4	0	7	0	7	0	4	1	2	0	4	7	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:23526667A>T	uc003jgo.2	+	11	1652	c.1470A>T	c.(1468-1470)GGA>GGT	p.G490G		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	490					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GTAGAGTGGGAAAAAGAATAA	0.443										HNSCC(3;0.000094)			12	11					0	0	0	0	T	23526667	T	T	23526667	2	4	107	1	0	0	0	0	0	0	0	1	12525	233	9	5		5	PRDM9	5	23526667	Silent	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	20774153	23526667	157388593	51	19951											
CDH10	1008	broad.mit.edu	37	chr5	24488021	24488021	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaatcccggacgtccgtgttAtctggagctgtaggagtcct	8	11	12	10	3	1	0	0	0	1	0	4	3	4	3	3	3	1	3	3	3	3	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:24488021A>T	uc003jgr.1	-	12	2450	c.2118T>A	c.(2116-2118)GAT>GAA	p.D706E	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	706	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		CGTCCGTGTTATCTGGAGCTG	0.488										HNSCC(23;0.051)			49	46					0	0	0	0	T	24488021	T	T	24488021	3	4	107	1	0	0	0	0	1	0	0	0	3111	446	16	5	252	5	CDH10	5	24488021	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	961354	24488021	156427239	52	19952											
FYB	2533	broad.mit.edu	37	chr5	39127888	39127888	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccatcataaatgtcatcaTctggtggtggagggaatatc	11	12	10	8	0	4	0	3	0	1	0	6	2	5	2	1	4	0	0	1	4	4	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:39127888T>C	uc003jls.2	-	10	1929	c.1862A>G	c.(1861-1863)GAT>GGT	p.D621G	FYB_uc003jlt.2_Missense_Mutation_p.D621G|FYB_uc003jlu.2_Missense_Mutation_p.D621G|FYB_uc011cpl.1_Missense_Mutation_p.D631G	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	621					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			AATGTCATCATCTGGTGGTGG	0.323													13	18					0	0	0	0	C	39127888	C	C	39127888	3	2	107	1	0	0	0	0	1	0	0	0	6158	1435	50	5	663	5	FYB	5	39127888	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	14639867	39127888	141787372	53	19953											
CHSY3	337876	broad.mit.edu	37	chr5	129520027	129520027	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taacacttcatcccaacaaaAggcctgcataccaatacagg	16	7	5	13	0	1	0	1	0	0	0	2	0	2	0	3	2	5	1	3	2	7	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:129520027A>G	uc003kvd.2	+	3	1192	c.1192A>G	c.(1192-1194)AGG>GGG	p.R398G		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	398	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		TCCCAACAAAAGGCCTGCATA	0.448													3	56					0	0	0	0	G	129520027	G	G	129520027	3	3	107	1	0	0	0	0	1	0	0	0	3428	63	3	5	1202	5	CHSY3	5	129520027	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	90392139	129520027	51395233	54	19954											
PCDHA7	56141	broad.mit.edu	37	chr5	140215088	140215088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcatcacattgattagcGtgtttgaccgagattttgga	9	14	10	8	3	2	3	2	2	0	1	2	5	2	4	2	1	1	1	2	1	1	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:140215088G>A	uc003lhq.2	+	1	1120	c.1120G>A	c.(1120-1122)GTG>ATG	p.V374M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.V374M	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	374	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGATTAGCGTGTTTGACCG	0.493													87	20					0	0	0	0	A	140215088	A	A	140215088	3	1	107	1	0	0	0	0	1	0	0	0	11583	1145	40	1	1122	1	PCDHA7	5	140215088	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	10695061	140215088	40700172	55	19955											
PCDHA13	56136	broad.mit.edu	37	chr5	140264051	140264051	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccaccgagggcgcgtgcgCgccgggcaagcccactctag	6	3	15	17	6	1	0	0	0	1	0	1	1	1	0	4	2	2	1	4	2	2	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:140264051C>T	uc003lif.2	+	1	2198	c.2198C>T	c.(2197-2199)GCG>GTG	p.A733V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.A733V|PCDHA13_uc003lid.2_Missense_Mutation_p.A733V	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	733	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGCGTGCGCGCCGGGCAAG	0.672													57	9					0	0	0	0	T	140264051	T	T	140264051	3	4	107	1	0	0	0	0	1	0	0	0	11577	768	27	1	2200	1	PCDHA13	5	140264051	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	48963	140264051	40651209	56	19956											
PCDHGA1	56114	broad.mit.edu	37	chr5	140710805	140710805	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctccctggatgtgcaacaggGagccgatgggcctcaacatc	9	7	12	13	1	1	0	1	0	0	0	3	3	2	2	3	3	4	1	3	3	2	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:140710805G>T	uc003lji.1	+	1	554	c.554G>T	c.(553-555)GGA>GTA	p.G185V	PCDHGA1_uc011dan.1_Missense_Mutation_p.G185V	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	185	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCAACAGGGAGCCGATGGG	0.527													60	9					1.1362e-29	1.44607e-29	1	0	T	140710805	T	T	140710805	3	4	107	1	0	0	0	0	1	0	0	0	11604	1174	41	2	556	2	PCDHGA1	5	140710805	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	446754	140710805	40204455	57	19957											
ABLIM3	22885	broad.mit.edu	37	chr5	148626086	148626086	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtctggaggagaggaggatGattttgaccgcagcatgcac	10	8	15	8	2	1	3	0	2	1	1	1	7	1	6	1	4	2	3	1	4	0	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:148626086G>C	uc003lpy.2	+	17	1779	c.1528G>C	c.(1528-1530)GAT>CAT	p.D510H	ABLIM3_uc003lpz.1_Missense_Mutation_p.D510H|ABLIM3_uc003lqa.1_Missense_Mutation_p.D407H|ABLIM3_uc003lqb.2_Missense_Mutation_p.D399H|ABLIM3_uc003lqc.1_Missense_Mutation_p.D477H|ABLIM3_uc003lqd.1_Missense_Mutation_p.D415H|ABLIM3_uc003lqf.2_Missense_Mutation_p.D399H|ABLIM3_uc003lqe.1_Missense_Mutation_p.D399H	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	510					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGGAGGATGATTTTGACCG	0.443													20	3					0	0	0	0	C	148626086	C	C	148626086	3	2	107	1	0	0	0	0	1	0	0	0	96	1290	45	2	1590	2	ABLIM3	5	148626086	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	7915281	148626086	32289174	58	19958											
RANBP17	64901	broad.mit.edu	37	chr5	170395247	170395247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttattttcccttcatgaagaGtttttcagcttatatcttta	9	21	4	7	0	3	2	2	1	1	1	4	2	4	2	1	0	1	2	1	0	5	10			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:170395247G>A	uc003mba.2	+	14	1592	c.1576G>A	c.(1576-1578)GTT>ATT	p.V526I	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	526					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTCATGAAGAGTTTTTCAGCT	0.289			T	TRD@	ALL								24	9					0	0	0	0	A	170395247	A	A	170395247	3	1	107	1	0	0	0	0	1	0	0	0	13092	1043	36	4	1630	4	RANBP17	5	170395247	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	21769161	170395247	10520013	59	19959											
STK10	6793	broad.mit.edu	37	chr5	171583735	171583735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagtcctccagctcctcctCactcttggtttcaatgactt	6	15	6	14	0	3	1	2	1	1	0	7	1	7	1	4	1	1	3	4	1	2	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:171583735C>T	uc003mbo.1	-	2	514	c.214G>A	c.(214-216)GAG>AAG	p.E72K		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	72	Protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGCTCCTCCTCACTCTTGGTT	0.547													54	16					0	0	0	0	T	171583735	T	T	171583735	3	4	107	1	0	0	0	0	1	0	0	0	15352	835	29	2	2764	2	STK10	5	171583735	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	1188488	171583735	9331525	60	19960											
RMND5B	64777	broad.mit.edu	37	chr5	177574774	177574774	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctggtaccactccgtgttCgcttgccccatcctccgcca	4	11	8	18	3	0	0	0	0	0	0	4	0	3	0	7	1	3	4	7	1	1	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:177574774C>T	uc003mim.2	+	10	1188	c.1008C>T	c.(1006-1008)TTC>TTT	p.F336F	RMND5B_uc003min.2_Silent_p.F336F|RMND5B_uc003mio.2_Silent_p.F323F|RMND5B_uc003mip.2_Silent_p.F336F|RMND5B_uc011dgf.1_Silent_p.F377F|RMND5B_uc003miq.2_Silent_p.F276F	NM_022762	NP_073599	Q96G75	RMD5B_HUMAN	required for meiotic nuclear division 5 homolog	336										ovary(1)|skin(1)	2	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACTCCGTGTTCGCTTGCCCCA	0.542													75	17					0	0	0	0	T	177574774	T	T	177574774	2	4	107	1	0	0	0	0	0	0	0	1	13463	883	31	1		1	RMND5B	5	177574774	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	5991039	177574774	3340486	61	19961											
ADAMTS2	9509	broad.mit.edu	37	chr5	178552137	178552137	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcacctgcatgcctgtcCgcccacaggtctggctacat	7	8	10	16	2	1	0	0	0	1	0	2	0	2	0	4	2	4	3	4	2	1	1	rs140022033	byFrequency	TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr5:178552137C>T	uc003mjw.2	-	19	2795	c.2795G>A	c.(2794-2796)CGG>CAG	p.R932Q		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	932	TSP type-1 3.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CATGCCTGTCCGCCCACAGGT	0.667													25	54					0	0	0	0	T	178552137	T	T	178552137	3	4	107	1	0	0	0	0	1	0	0	0	265	652	23	1	856	1	ADAMTS2	5	178552137	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	977363	178552137	2363123	62	19962											
RNF182	221687	broad.mit.edu	37	chr6	13977531	13977531	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggggactccccacaaggtGtcattgtctgtcctttctgc	5	14	10	12	0	3	0	1	0	2	0	5	1	5	1	3	3	1	0	3	3	1	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:13977531G>T	uc003nbe.2	+	3	599	c.181G>T	c.(181-183)GTC>TTC	p.V61F	RNF182_uc003nbf.2_Missense_Mutation_p.V61F|RNF182_uc003nbg.2_Missense_Mutation_p.V61F	NM_152737	NP_689950	Q8N6D2	RN182_HUMAN	ring finger protein 182	61	RING-type.					cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			CCCACAAGGTGTCATTGTCTG	0.473													8	116					0.00621372	0.00699433	1	0	T	13977531	T	T	13977531	3	4	107	1	0	0	0	0	1	0	0	0	13531	1377	48	4	183	4	RNF182	6	13977531	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08		13977531	157137536	63	19963											
HIST1H3C	8352	broad.mit.edu	37	chr6	26045748	26045748	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccggccaccggtggcgtgaAgaaacctcatcgctaccgcc	8	6	11	16	5	1	2	1	1	0	1	3	2	2	2	6	3	2	1	6	3	3	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:26045748A>T	uc003nfv.2	+	1	110	c.110A>T	c.(109-111)AAG>ATG	p.K37M	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	37					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GGTGGCGTGAAGAAACCTCAT	0.632													21	40					0	0	0	0	T	26045748	T	T	26045748	3	4	107	1	0	0	0	0	1	0	0	0	7196	72	3	5	112	5	HIST1H3C	6	26045748	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	12068217	26045748	145069319	64	19964											
HIST1H4G	8369	broad.mit.edu	37	chr6	26246938	26246938	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttccctggcgtttgagcaCgtagaccacggccatggcgg	6	9	13	13	4	1	2	0	1	1	1	2	2	2	2	3	4	1	3	3	4	1	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:26246938C>T	uc003nhf.2	-	1	268	c.268G>A	c.(268-270)GTG>ATG	p.V90M		NM_003547	NP_003538	Q99525	H4G_HUMAN	histone cluster 1, H4g	90					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				CGTTTGAGCACGTAGACCACG	0.572													12	44					0	0	0	0	T	26246938	T	T	26246938	3	4	107	1	0	0	0	0	1	0	0	0	7210	536	19	1	32	1	HIST1H4G	6	26246938	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	201190	26246938	144868129	65	19965											
OR2B6	26212	broad.mit.edu	37	chr6	27925114	27925114	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccactccttgtggtcttcttGatttcttacactgtgaccat	6	17	6	12	0	3	2	0	2	3	0	4	2	4	2	3	1	1	0	3	1	1	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:27925114G>C	uc011dkx.1	+	1	96	c.96G>C	c.(94-96)TTG>TTC	p.L32F		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGGTCTTCTTGATTTCTTACA	0.418													9	88					0	0	0	0	C	27925114	C	C	27925114	3	2	107	1	0	0	0	0	1	0	0	0	11045	1281	45	2	98	2	OR2B6	6	27925114	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	1678176	27925114	143189953	66	19966											
HSD17B8	7923	broad.mit.edu	37	chr6	33173441	33173442	+	Frame_Shift_Del	DEL	TA	-	-																															ggaacgtggggcagacaaacTatgcagcatccaaggctgga																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:33173441_33173442delTA	uc003odi.1	+	5	532_533	c.505_506delTA	c.(505-507)TATfs	p.Y169fs	uc003odj.1_5'Flank|MIR219-1_hsa-mir-219-1|MI0000296_5'Flank|RING1_uc011dqw.1_5'Flank|RING1_uc011dqx.1_5'Flank|RING1_uc003odk.2_5'Flank	NM_014234	NP_055049	Q92506	DHB8_HUMAN	estradiol 17 beta-dehydrogenase 8	169	NAD.	Proton acceptor (By similarity).			estrogen biosynthetic process|fatty acid biosynthetic process	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(1)|central_nervous_system(1)	2					NADH(DB00157)	GCAGACAAACTATGCAGCATCC	0.589													---	---	---								-	33173442	-	-	33173441	7	5	107	1	0	1	0	1	0	0	0	0	7428	1522	53	0	523	0	HSD17B8	6	33173441	Frame_Shift_Del	DEL	TA	TCGA-CQ-6225-01A-11D-1912-08	5248327	33173441	137941626	67	19967											
DNAH8	1769	broad.mit.edu	37	chr6	38899605	38899605	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggtgaaagtcggtgataagGaatgtgatatcatggataca	15	10	13	3	1	1	3	1	3	0	0	2	5	1	5	0	4	1	0	0	4	5	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:38899605G>A	uc003ooe.1	+	74	11242	c.10642G>A	c.(10642-10644)GAA>AAA	p.E3548K	DNAH8_uc003oog.1_5'UTR|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CGGTGATAAGGAATGTGATAT	0.234													37	107					0	0	0	0	A	38899605	A	A	38899605	3	1	107	1	0	0	0	0	1	0	0	0	4629	1175	41	2	10928	2	DNAH8	6	38899605	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	5726164	38899605	132215462	68	19968											
SLC35B2	347734	broad.mit.edu	37	chr6	44222449	44222451	+	In_Frame_Del	DEL	CTT	-	-																															ggccctttccaccctcaaacCttctgcacaggagactcaac																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:44222449_44222451delCTT	uc003oxd.2	-	4	1427_1429	c.1291_1293delAAG	c.(1291-1293)AAGdel	p.K431del	SLC35B2_uc011dvt.1_In_Frame_Del_p.K334del|SLC35B2_uc011dvu.1_In_Frame_Del_p.K298del	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	431					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACCCTCAAACCTTCTGCACAGGA	0.576													---	---	---								-	44222451	-	-	44222449	7	5	107	1	0	1	0	1	0	0	0	0	14640	680	24	0	9	0	SLC35B2	6	44222449	In_Frame_Del	DEL	CTT	TCGA-CQ-6225-01A-11D-1912-08	5322844	44222449	126892618	69	19969											
TDRD6	221400	broad.mit.edu	37	chr6	46658979	46658979	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcccttgaaccctggaacCttgtgccttgccaagtatac	8	12	7	14	0	1	1	0	1	1	0	2	2	1	2	5	1	5	1	5	1	5	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:46658979C>T	uc003oyj.2	+	1	3114	c.3114C>T	c.(3112-3114)ACC>ACT	p.T1038T	TDRD6_uc010jze.2_Silent_p.T1032T	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1038	Tudor 5.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			ACCCTGGAACCTTGTGCCTTG	0.348													5	63					0	0	0	0	T	46658979	T	T	46658979	2	4	107	1	0	0	0	0	0	0	0	1	15800	668	24	4		4	TDRD6	6	46658979	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	2436530	46658979	124456088	70	19970											
C6orf167	253714	broad.mit.edu	37	chr6	97676903	97676903	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacaagcaatagctggtctCaaacacttcttgaacaccat	15	10	5	11	0	2	1	1	1	2	0	3	1	2	1	1	1	5	2	1	1	6	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:97676903C>G	uc003ppb.2	-	14	2172	c.1906G>C	c.(1906-1908)GAG>CAG	p.E636Q	C6orf167_uc011eaf.1_Missense_Mutation_p.E596Q	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	636					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		TAGCTGGTCTCAAACACTTCT	0.398													34	36					0	0	0	0	G	97676903	G	G	97676903	3	3	107	1	0	0	0	0	1	0	0	0	2352	835	29	2	1873	2	C6orf167	6	97676903	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	51017924	97676903	73438164	71	19971											
C6orf167	253714	broad.mit.edu	37	chr6	97694537	97694537	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gactttttcagcagttcttcTacaaagttccaatttgattc	10	17	5	9	0	3	1	1	1	2	0	5	2	4	1	1	0	2	3	1	0	3	8			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:97694537T>C	uc003ppb.2	-	11	1415	c.1149A>G	c.(1147-1149)GTA>GTG	p.V383V	C6orf167_uc011eaf.1_Silent_p.V383V|C6orf167_uc010kcn.1_Silent_p.V157V|C6orf167_uc010kco.1_Silent_p.V119V	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	383					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		GCAGTTCTTCTACAAAGTTCC	0.289													18	15					0	0	0	0	C	97694537	C	C	97694537	2	2	107	1	0	0	0	0	0	0	0	1	2352	1509	53	5		5	C6orf167	6	97694537	Silent	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	17634	97694537	73420530	72	19972											
AKD1	221264	broad.mit.edu	37	chr6	109867278	109867279	+	Frame_Shift_Del	DEL	AT	-	-																															ctgccaactgtcttccacacAtagttttgccagagccctgg																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:109867278_109867279delAT	uc003ptn.2	-	26	3093_3094	c.3016_3017delAT	c.(3016-3018)ATGfs	p.M1006fs	AKD1_uc011eat.1_Frame_Shift_Del_p.M85fs	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1006					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						TCTTCCACACATAGTTTTGCCA	0.45													---	---	---								-	109867279	-	-	109867278	7	5	107	1	0	1	0	1	0	0	0	0	460	217	8	0	2782	0	AKD1	6	109867278	Frame_Shift_Del	DEL	AT	TCGA-CQ-6225-01A-11D-1912-08	12172741	109867278	61247789	73	19973											
GPR6	2830	broad.mit.edu	37	chr6	110301053	110301053	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatgctgcacctgtacgtGcgcatctgccaggtggtctg	6	11	12	12	2	3	0	1	0	2	0	3	0	3	0	2	2	5	4	2	2	1	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:110301053G>A	uc011eaw.1	+	2	918	c.738G>A	c.(736-738)GTG>GTA	p.V246V	GPR6_uc011eav.1_Silent_p.V261V|GPR6_uc003ptu.2_Silent_p.V246V	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	246	Helical; Name=5; (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		ACCTGTACGTGCGCATCTGCC	0.687													17	12					0	0	0	0	A	110301053	A	A	110301053	2	1	107	1	0	0	0	0	0	0	0	1	6739	1306	46	4		4	GPR6	6	110301053	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	433775	110301053	60814014	74	19974											
COL10A1	1300	broad.mit.edu	37	chr6	116443007	116443007	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcaaccctggctctcctTggagtccaggacttccgtag	6	10	11	14	1	1	0	0	0	1	0	4	2	3	2	4	4	1	3	4	4	2	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:116443007T>G	uc003pwm.2	-	3	368	c.272A>C	c.(271-273)CAA>CCA	p.Q91P	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	91	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		TGGCTCTCCTTGGAGTCCAGG	0.607													8	66					0	0	0	0	G	116443007	G	G	116443007	3	3	107	1	0	0	0	0	1	0	0	0	3681	1812	63	5	1774	5	COL10A1	6	116443007	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	6141954	116443007	54672060	75	19975											
FAM184A	79632	broad.mit.edu	37	chr6	119295637	119295637	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttgagtagctcgttagtCttattaaaatctgcccgcat	9	15	7	10	2	2	1	0	1	2	0	4	1	3	1	2	0	2	4	2	0	5	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:119295637C>A	uc003pyj.2	-	14	3219	c.2871G>T	c.(2869-2871)AAG>AAT	p.K957N	FAM184A_uc003pyk.3_Intron|FAM184A_uc003pyl.3_Intron|FAM184A_uc003pyi.2_RNA	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	957										ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						GCTCGTTAGTCTTATTAAAAT	0.348													47	132					1.07234e-20	1.33447e-20	1	0	A	119295637	A	A	119295637	3	1	107	1	0	0	0	0	1	0	0	0	5539	912	32	2	571	2	FAM184A	6	119295637	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	2852630	119295637	51819430	76	19976											
GRM1	2911	broad.mit.edu	37	chr6	146755396	146755396	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaagggcttgccccctcctCtccagcagcagcagcaaccc	8	5	8	20	0	1	0	0	0	1	0	3	0	2	0	6	1	6	5	6	1	2	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr6:146755396C>T	uc010khw.1	+	9	3519	c.3049C>T	c.(3049-3051)CTC>TTC	p.L1017F	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1017	Gln/Pro-rich.|Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GCCCCCTCCTCTCCAGCAGCA	0.652													36	64					0	0	0	0	T	146755396	T	T	146755396	3	4	107	1	0	0	0	0	1	0	0	0	6835	913	32	2	3144	2	GRM1	6	146755396	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	27459759	146755396	24359671	77	19977											
DAGLB	221955	broad.mit.edu	37	chr7	6452649	6452649	+	Frame_Shift_Del	DEL	A	-	-																															cacgatgaagctctgagaatAttcctgcagagctttgctga																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:6452649delA	uc003sqa.2	-	12	1614	c.1444delT	c.(1444-1446)TATfs	p.Y482fs	DAGLB_uc003spy.2_Frame_Shift_Del_p.Y28fs|DAGLB_uc003spz.2_Frame_Shift_Del_p.Y179fs|DAGLB_uc011jwt.1_Frame_Shift_Del_p.Y296fs|DAGLB_uc011jwu.1_Frame_Shift_Del_p.Y353fs|DAGLB_uc003sqb.2_Frame_Shift_Del_p.Y201fs|DAGLB_uc003sqc.2_Frame_Shift_Del_p.Y201fs|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Frame_Shift_Del_p.Y441fs|DAGLB_uc011jww.1_RNA	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	482	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		CTCTGAGAATATTCCTGCAGA	0.517													---	---	---								-	6452649	-	-	6452649	7	5	107	1	0	1	0	1	0	0	0	0	4244	449	16	0	590	0	DAGLB	7	6452649	Frame_Shift_Del	DEL	A	TCGA-CQ-6225-01A-11D-1912-08		6452649	152686014	78	19978											
PDE1C	5137	broad.mit.edu	37	chr7	31917639	31917639	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaaccatgtttgatgtccGtctatacattctgaaaagcc	11	13	6	11	1	2	2	0	2	2	0	4	2	4	2	4	0	3	1	4	0	5	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:31917639G>A	uc003tcm.1	-	5	905	c.436C>T	c.(436-438)CGG>TGG	p.R146W	PDE1C_uc003tcn.1_Missense_Mutation_p.R146W|PDE1C_uc003tco.1_Missense_Mutation_p.R206W|PDE1C_uc003tcr.2_Missense_Mutation_p.R146W|PDE1C_uc003tcs.2_Missense_Mutation_p.R146W	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	146					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TTTGATGTCCGTCTATACATT	0.343													8	35					0	0	0	0	A	31917639	A	A	31917639	3	1	107	1	0	0	0	0	1	0	0	0	11689	1144	40	1	1520	1	PDE1C	7	31917639	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	25464990	31917639	127221024	79	19979											
EIF4H	7458	broad.mit.edu	37	chr7	73604163	73604171	+	In_Frame_Del	DEL	TCGGTCACT	-	-																															tatcattagctgttgggcgaTcggtcacttcgtgtggacat																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:73604163_73604171delTCGGTCACT	uc003uad.1	+	4	332_340	c.324_332delTCGGTCACT	c.(322-333)GATCGGTCACTT>GAT	p.RSL109del	RFC2_uc011kfa.1_Intron|EIF4H_uc011kfg.1_In_Frame_Del_p.RSL109del|EIF4H_uc010lbm.2_In_Frame_Del_p.RSL109del|EIF4H_uc003uae.1_In_Frame_Del_p.RSL109del|EIF4H_uc003uaf.1_RNA|MIR590_hsa-mir-590|MI0003602_5'Flank	NM_022170	NP_071496	Q15056	IF4H_HUMAN	eukaryotic translation initiation factor 4H	109_111	RRM.				interspecies interaction between organisms|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0						TGTTGGGCGATCGGTCACTTCGTGTGGAC	0.426													---	---	---								-	73604171	-	-	73604163	7	5	107	1	0	1	0	1	0	0	0	0	5063	1432	50	0	338	0	EIF4H	7	73604163	In_Frame_Del	DEL	TCGGTCACT	TCGA-CQ-6225-01A-11D-1912-08	41686524	73604163	85534500	80	19980											
STEAP4	79689	broad.mit.edu	37	chr7	87908901	87908907	+	Frame_Shift_Del	DEL	TGTGGGC	-	-																															cttcccaccgtacaccagggTgtgggctgtacacaagatca																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:87908901_87908907delTGTGGGC	uc003ujs.2	-	5	1291_1297	c.1186_1192delGCCCACA	c.(1186-1194)GCCCACACCfs	p.A396fs	STEAP4_uc010lek.2_Frame_Shift_Del_p.A220fs	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	396_398	Helical; (Potential).				fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					TACACCAGGGTGTGGGCTGTACACAAG	0.411													---	---	---								-	87908907	-	-	87908901	7	5	107	1	0	1	0	1	0	0	0	0	15346	1696	59	0	191	0	STEAP4	7	87908901	Frame_Shift_Del	DEL	TGTGGGC	TCGA-CQ-6225-01A-11D-1912-08	14304738	87908901	71229762	81	19981											
AZGP1	563	broad.mit.edu	37	chr7	99565809	99565809	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatatttttgctgtatttCaggtatttccgcagagtcgc	8	16	10	7	2	1	1	1	0	0	1	3	2	2	2	1	2	1	4	1	2	3	7			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:99565809C>A	uc003ush.2	-	3	626	c.582G>T	c.(580-582)CTG>CTT	p.L194L		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	194					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					TGCTGTATTTCAGGTATTTCC	0.547													37	44					1.836e-18	2.25969e-18	1	0	A	99565809	A	A	99565809	2	1	107	1	0	0	0	0	0	0	0	1	1241	813	29	2		2	AZGP1	7	99565809	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	11656908	99565809	59572854	82	19982											
RELN	5649	broad.mit.edu	37	chr7	103143679	103143679	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttacatccaactgagatcTaataaacagaaaaacaagat	20	8	4	9	0	1	3	0	1	1	3	2	4	2	3	2	0	4	0	2	0	8	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:103143679T>A	uc003vca.2	-	52	8435	c.8275_splice	c.e52-1	p.I2759_splice	RELN_uc010liz.2_Splice_Site_p.I2759_splice	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a						axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AACTGAGATCTAATAAACAGA	0.368													13	38					0	0	0	0	A	103143679	A	A	103143679	5	1	107	1	0	0	0	0	0	0	1	0	13285	1536	53	5	2165	5	RELN	7	103143679	Splice_Site	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	3577870	103143679	55994984	83	19983											
ASB15	142685	broad.mit.edu	37	chr7	123267298	123267298	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctaaccgagcaggacatCttcctatacaccgagctgcc	11	8	7	15	2	1	0	0	0	1	0	2	3	2	1	5	1	6	2	5	1	4	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:123267298C>A	uc003vku.1	+	9	1124	c.832C>A	c.(832-834)CTT>ATT	p.L278I	ASB15_uc003vkv.1_Missense_Mutation_p.L278I|ASB15_uc003vkw.1_Missense_Mutation_p.L278I	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	278					intracellular signal transduction					skin(2)|lung(1)	3						AGCAGGACATCTTCCTATACA	0.438													18	23					1.33834e-09	1.59461e-09	1	0	A	123267298	A	A	123267298	3	1	107	1	0	0	0	0	1	0	0	0	1021	913	32	2	854	2	ASB15	7	123267298	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	20123619	123267298	35871365	84	19984											
ASB15	142685	broad.mit.edu	37	chr7	123269291	123269291	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttattttatgcatgtgaatGacactcgtttccccagtgtc	8	16	8	9	1	0	2	0	2	0	0	3	2	1	2	2	0	1	3	2	0	3	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:123269291G>C	uc003vku.1	+	10	1535	c.1243G>C	c.(1243-1245)GAC>CAC	p.D415H	ASB15_uc003vkw.1_Missense_Mutation_p.D415H	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	415					intracellular signal transduction					skin(2)|lung(1)	3						GCATGTGAATGACACTCGTTT	0.418													25	83					0	0	0	0	C	123269291	C	C	123269291	3	2	107	1	0	0	0	0	1	0	0	0	1021	1290	45	2	1269	2	ASB15	7	123269291	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	1993	123269291	35869372	85	19985											
HIPK2	28996	broad.mit.edu	37	chr7	139258060	139258060	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgttgtgcgggaaggagtaCggagcctgggccatggtggg	6	8	20	7	2	0	0	0	0	0	0	0	3	0	3	2	6	3	2	2	6	2	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:139258060C>T	uc003vvf.3	-	15	3384	c.3210G>A	c.(3208-3210)CCG>CCA	p.P1070P	HIPK2_uc003vvd.3_Silent_p.P1043P	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	1070	Autoinhibitory domain (AID).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					GGAAGGAGTACGGAGCCTGGG	0.682													47	77					0	0	0	0	T	139258060	T	T	139258060	2	4	107	1	0	0	0	0	0	0	0	1	7156	523	19	1		1	HIPK2	7	139258060	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	15988769	139258060	19880603	86	19986											
MGAM	8972	broad.mit.edu	37	chr7	141722076	141722076	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctgtgtctaggtttgactCgagcattgggcccctactgt	6	13	11	11	1	1	1	0	1	1	0	2	2	1	1	3	2	2	2	3	2	2	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:141722076C>T	uc003vwy.2	+	7	773	c.719C>T	c.(718-720)TCG>TTG	p.S240L		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	240	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AGGTTTGACTCGAGCATTGGG	0.522													30	52					0	0	0	0	T	141722076	T	T	141722076	3	4	107	1	0	0	0	0	1	0	0	0	9594	893	31	1	741	1	MGAM	7	141722076	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	2464016	141722076	17416587	87	19987											
ZNF212	7988	broad.mit.edu	37	chr7	148947393	148947393	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtggagaagaagatggaGtcccaggctgcccggctaca	10	6	15	10	1	0	3	0	0	0	3	1	5	1	4	2	4	2	3	2	4	3	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:148947393G>A	uc003wfp.2	+	2	264	c.168G>A	c.(166-168)GAG>GAA	p.E56E		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	56					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			AGAAGATGGAGTCCCAGGCTG	0.582													6	80					0	0	0	0	A	148947393	A	A	148947393	2	1	107	1	0	0	0	0	0	0	0	1	17835	1020	36	4		4	ZNF212	7	148947393	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	7225317	148947393	10191270	88	19988											
HTR5A	3361	broad.mit.edu	37	chr7	154862705	154862705	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagacgacctgcgccccagCtcgcccctgctctcggtctt	6	8	9	18	4	2	1	0	0	2	1	4	2	2	1	5	1	3	2	5	1	1	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr7:154862705C>T	uc003wlu.1	+	1	160	c.96C>T	c.(94-96)AGC>AGT	p.S32S	uc011kvt.1_Intron|uc003wlt.2_Intron	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	32	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TGCGCCCCAGCTCGCCCCTGC	0.607													23	87					0	0	0	0	T	154862705	T	T	154862705	2	4	107	1	0	0	0	0	0	0	0	1	7489	796	28	4		4	HTR5A	7	154862705	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	5915312	154862705	4275958	89	19989											
SGK223	157285	broad.mit.edu	37	chr8	8185978	8185978	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccagctcagacgagggacCtgaagaggagagacagaaac	16	2	14	9	1	1	5	1	1	0	4	1	9	1	7	2	2	3	1	2	2	2	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr8:8185978C>G	uc003wsh.3	-	4	2315	c.2315_splice	c.e4-1	p.G772_splice		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin								ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GACGAGGGACCTGAAGAGGAG	0.522													8	6					0	0	0	0	G	8185978	G	G	8185978	5	3	107	1	0	0	0	0	0	0	1	0	14275	695	24	4	1902	4	SGK223	8	8185978	Splice_Site	SNP	C	TCGA-CQ-6225-01A-11D-1912-08		8185978	138178044	90	19990											
GSR	2936	broad.mit.edu	37	chr8	30557645	30557645	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatcgctggttattcctaaGctggcacctatgtagaaaaa	12	11	8	10	1	0	1	0	0	0	1	2	1	1	1	3	2	1	5	3	2	6	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr8:30557645G>A	uc003xih.1	-	6	739	c.648C>T	c.(646-648)AGC>AGT	p.S216S		NM_000637	NP_000628	P00390	GSHR_HUMAN	glutathione reductase precursor	216					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			ovary(2)|pancreas(2)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TTATTCCTAAGCTGGCACCTA	0.433													41	12					0	0	0	0	A	30557645	A	A	30557645	2	1	107	1	0	0	0	0	0	0	0	1	6867	962	34	4		4	GSR	8	30557645	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	22371667	30557645	115806377	91	19991											
PXDNL	137902	broad.mit.edu	37	chr8	52320696	52320696	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaaagttcttaactgaaGtcaaattacagaaaactctg	16	11	5	9	0	4	2	2	1	2	1	4	2	4	2	1	0	3	1	1	0	7	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr8:52320696G>A	uc003xqu.3	-	17	3589	c.3488C>T	c.(3487-3489)ACT>ATT	p.T1163I	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1163					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTTAACTGAAGTCAAATTACA	0.403													4	82					0	0	0	0	A	52320696	A	A	52320696	3	1	107	1	0	0	0	0	1	0	0	0	12913	1029	36	4	931	4	PXDNL	8	52320696	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	21763051	52320696	94043326	92	19992											
PCMTD1	115294	broad.mit.edu	37	chr8	52773448	52773448	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttaaatatccggttccactTcccaggttaagaaaagacaa	15	10	6	10	1	0	2	0	0	0	2	3	2	3	2	3	2	0	2	3	2	7	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr8:52773448T>C	uc003xqx.3	-	2	605	c.264A>G	c.(262-264)GGA>GGG	p.G88G	PCMTD1_uc003xqw.3_Silent_p.G88G|PCMTD1_uc011ldn.1_Intron|PCMTD1_uc010lya.2_Intron|PCMTD1_uc011ldo.1_Silent_p.G88G	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	88						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				CGGTTCCACTTCCCAGGTTAA	0.323													3	36					0	0	0	0	C	52773448	C	C	52773448	2	2	107	1	0	0	0	0	0	0	0	1	11640	1770	62	5		5	PCMTD1	8	52773448	Silent	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	452752	52773448	93590574	93	19993											
ST18	9705	broad.mit.edu	37	chr8	53126796	53126796	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagcgagtacgcagcgtttTatcttcagcctctgcatcca	9	11	9	12	3	3	1	1	0	2	1	4	2	4	1	2	0	5	4	2	0	2	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr8:53126796T>C	uc003xqz.2	-	2	178	c.22A>G	c.(22-24)AAA>GAA	p.K8E	ST18_uc011ldq.1_Translation_Start_Site|ST18_uc011ldr.1_Translation_Start_Site|ST18_uc011lds.1_Translation_Start_Site|ST18_uc003xra.2_Missense_Mutation_p.K8E|ST18_uc003xrb.2_Missense_Mutation_p.K8E|ST18_uc010lyb.2_RNA	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	8						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CGCAGCGTTTTATCTTCAGCC	0.428													58	68					0	0	0	0	C	53126796	C	C	53126796	3	2	107	1	0	0	0	0	1	0	0	0	15278	1763	61	5	3201	5	ST18	8	53126796	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	353348	53126796	93237226	94	19994											
MOS	4342	broad.mit.edu	37	chr8	57025569	57025569	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgctcggcctctgcgccgCgctgggtctccagcagcgct	2	7	14	18	7	2	0	0	0	2	0	4	0	2	0	3	2	3	4	3	2	0	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr8:57025569C>T	uc011leb.1	-	1	973	c.973G>A	c.(973-975)GCG>ACG	p.A325T		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	325	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			CTCTGCGCCGCGCTGGGTCTC	0.632													18	25					0	0	0	0	T	57025569	T	T	57025569	3	4	107	1	0	0	0	0	1	0	0	0	9765	768	27	1	70	1	MOS	8	57025569	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	3898773	57025569	89338453	95	19995											
SGK3	23678	broad.mit.edu	37	chr8	67740926	67740926	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacatcaacctgggaccgtCtggaaatcctcagtatgttt	11	11	9	10	1	3	0	2	0	1	0	4	3	4	2	3	2	2	2	3	2	4	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr8:67740926C>A	uc003xwr.2	+	7	754	c.455C>A	c.(454-456)TCT>TAT	p.S152Y	SGK3_uc003xwp.2_Missense_Mutation_p.S146Y|SGK3_uc003xwt.2_Missense_Mutation_p.S152Y|SGK3_uc003xwu.2_Missense_Mutation_p.S152Y	NM_001033578	NP_001028750	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase 3 isoform	152					cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			ovary(1)|large_intestine(1)|lung(1)|breast(1)	4	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CTGGGACCGTCTGGAAATCCT	0.328													45	81					2.48909e-17	3.04675e-17	1	0	A	67740926	A	A	67740926	3	1	107	1	0	0	0	0	1	0	0	0	14277	913	32	2	477	2	SGK3	8	67740926	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	10715357	67740926	78623096	96	19996											
TRAM1	23471	broad.mit.edu	37	chr8	71487192	71487192	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatttctcttttttattcCggggagagtctgctacattt	8	18	8	7	1	2	2	0	0	2	2	4	3	3	2	1	2	2	1	1	2	3	7			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr8:71487192C>T	uc003xyo.1	-	11	1270	c.1100G>A	c.(1099-1101)CGG>CAG	p.R367Q	TRAM1_uc011lfc.1_Missense_Mutation_p.R336Q	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	367	Cytoplasmic (Potential).				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			TTTTTTATTCCGGGGAGAGTC	0.294													18	14					0	0	0	0	T	71487192	T	T	71487192	3	4	107	1	0	0	0	0	1	0	0	0	16518	652	23	1	28	1	TRAM1	8	71487192	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	3746266	71487192	74876830	97	19997											
ZFPM2	23414	broad.mit.edu	37	chr8	106815640	106815640	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atagcaaaaggtgtgaatggTtccagccaggctccaaccag	13	7	11	10	0	0	1	0	1	0	0	2	1	2	1	4	3	3	3	4	3	5	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr8:106815640T>C	uc003ymd.2	+	8	3353	c.3330T>C	c.(3328-3330)GGT>GGC	p.G1110G	ZFPM2_uc011lhs.1_Silent_p.G841G	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	1110					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GTGTGAATGGTTCCAGCCAGG	0.438													21	22					0	0	0	0	C	106815640	C	C	106815640	2	2	107	1	0	0	0	0	0	0	0	1	17725	1712	60	5		5	ZFPM2	8	106815640	Silent	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	35328448	106815640	39548382	98	19998											
FAM83H	286077	broad.mit.edu	37	chr8	144808950	144808950	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgctcgataaatcctgtaGttggacttcctcttcgagtg	7	15	9	10	2	2	0	0	0	2	0	6	3	4	1	2	1	1	3	2	1	3	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr8:144808950G>C	uc003yzk.2	-	5	2750	c.2681C>G	c.(2680-2682)ACT>AGT	p.T894S	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	894					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AAATCCTGTAGTTGGACTTCC	0.637													20	22					0	0	0	0	C	144808950	C	C	144808950	3	2	107	1	0	0	0	0	1	0	0	0	5672	1029	36	4	862	4	FAM83H	8	144808950	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	37993310	144808950	1555072	99	19999											
WNK2	65268	broad.mit.edu	37	chr9	96055448	96055448	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaaggagctgcagagtctgCgggagaagtaggtcctgcgg	10	6	18	7	2	1	3	0	0	1	3	2	5	2	4	1	4	4	3	1	4	3	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr9:96055448C>T	uc004ati.1	+	23	5812	c.5812C>T	c.(5812-5814)CGG>TGG	p.R1938W	WNK2_uc011lud.1_Missense_Mutation_p.R1901W|WNK2_uc004atj.2_Missense_Mutation_p.R1901W|WNK2_uc004atk.2_Missense_Mutation_p.R1538W|WNK2_uc004atl.1_Missense_Mutation_p.R495W	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1938					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						GCAGAGTCTGCGGGAGAAGTA	0.607													7	6					0	0	0	0	T	96055448	T	T	96055448	3	4	107	1	0	0	0	0	1	0	0	0	17446	759	27	1	5787	1	WNK2	9	96055448	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08		96055448	45157983	100	20000											
FAM22G	441457	broad.mit.edu	37	chr9	99694193	99694193	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctctagtggcaggacaggAtggccgcggcccaagtgggg	7	5	17	12	2	1	0	0	0	1	0	1	2	1	2	3	7	0	1	3	7	2	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr9:99694193A>C	uc004awq.1	+	2	921	c.206A>C	c.(205-207)GAT>GCT	p.D69A		NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	69										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)				GCAGGACAGGATGGCCGCGGC	0.647													12	16					0	0	0	0	C	99694193	C	C	99694193	3	2	107	1	0	0	0	0	1	0	0	0	5574	333	12	5	212	5	FAM22G	9	99694193	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	3638745	99694193	41519238	101	20001											
DBC1	1620	broad.mit.edu	37	chr9	121929496	121929496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagcatacaggagaacaagtCcagctggggtttccccgggg	10	6	14	11	1	0	1	0	0	0	1	2	2	2	1	3	5	4	3	3	5	3	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr9:121929496C>T	uc004bkc.2	-	8	2608	c.2152G>A	c.(2152-2154)GAC>AAC	p.D718N		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	718					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GAGAACAAGTCCAGCTGGGGT	0.542													6	117					0	0	0	0	T	121929496	T	T	121929496	3	4	107	1	0	0	0	0	1	0	0	0	4264	855	30	2	137	2	DBC1	9	121929496	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	22235303	121929496	19283935	102	20002											
GPR21	2844	broad.mit.edu	37	chr9	125797792	125797792	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtattccaaagaggactaaAgcgcctctcaggggctatgt	11	10	11	9	1	1	1	1	0	1	1	3	2	2	2	2	3	1	2	2	3	5	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr9:125797792A>G	uc011lzk.1	+	1	947	c.947A>G	c.(946-948)AAG>AGG	p.K316R	RABGAP1_uc004bnl.3_Intron|RABGAP1_uc011lzh.1_Intron|RABGAP1_uc011lzj.1_Intron|GPR21_uc011lzi.1_RNA	NM_005294	NP_005285	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	316	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1						AGAGGACTAAAGCGCCTCTCA	0.453													51	41					0	0	0	0	G	125797792	G	G	125797792	3	3	107	1	0	0	0	0	1	0	0	0	6719	72	3	5	949	5	GPR21	9	125797792	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	3868296	125797792	15415639	103	20003											
ST6GALNAC6	30815	broad.mit.edu	37	chr9	130653215	130653215	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagtggtgggtgcatcattCatgcggattgtacactcagc	8	11	12	10	1	3	0	3	0	0	0	3	1	3	1	1	3	4	2	1	3	1	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr9:130653215C>T	uc004bso.1	-	5	524	c.405G>A	c.(403-405)ATG>ATA	p.M135I	ST6GALNAC6_uc004bsn.1_Missense_Mutation_p.M101I|ST6GALNAC6_uc011man.1_Intron|ST6GALNAC6_uc004bsp.1_Missense_Mutation_p.M135I|ST6GALNAC6_uc004bsq.1_Missense_Mutation_p.M101I|ST6GALNAC6_uc004bsr.2_Missense_Mutation_p.M101I|ST6GALNAC6_uc010mxp.1_RNA	NM_013443	NP_038471	Q969X2	SIA7F_HUMAN	sialytransferase 7F	135	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane|plasma membrane					0						GTGCATCATTCATGCGGATTG	0.617													14	33					0	0	0	0	T	130653215	T	T	130653215	3	4	107	1	0	0	0	0	1	0	0	0	15294	826	29	2	608	2	ST6GALNAC6	9	130653215	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	4855423	130653215	10560216	104	20004											
ST6GALNAC6	30815	broad.mit.edu	37	chr9	130653241	130653241	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gattgtacactcagcccgctCgatctcagggcccagcttgg	7	9	11	14	2	2	0	2	0	1	0	4	2	2	0	2	2	3	3	2	2	1	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr9:130653241C>G	uc004bso.1	-	5	498	c.379G>C	c.(379-381)GAG>CAG	p.E127Q	ST6GALNAC6_uc004bsn.1_Missense_Mutation_p.E93Q|ST6GALNAC6_uc011man.1_Intron|ST6GALNAC6_uc004bsp.1_Missense_Mutation_p.E127Q|ST6GALNAC6_uc004bsq.1_Missense_Mutation_p.E93Q|ST6GALNAC6_uc004bsr.2_Missense_Mutation_p.E93Q|ST6GALNAC6_uc010mxp.1_RNA	NM_013443	NP_038471	Q969X2	SIA7F_HUMAN	sialytransferase 7F	127	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane|plasma membrane					0						TCAGCCCGCTCGATCTCAGGG	0.592													15	28					0	0	0	0	G	130653241	G	G	130653241	3	3	107	1	0	0	0	0	1	0	0	0	15294	893	31	3	634	3	ST6GALNAC6	9	130653241	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	26	130653241	10560190	105	20005											
CDH23	64072	broad.mit.edu	37	chr10	73405728	73405728	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacgagaccgtggaccgctaCgactttgatgtaaggcccca	10	8	11	12	4	0	2	0	1	0	1	0	5	0	3	4	2	2	2	4	2	3	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr10:73405728C>T	uc001jrx.3	+	12	1658	c.1281C>T	c.(1279-1281)TAC>TAT	p.Y427Y	CDH23_uc001jrw.3_Silent_p.Y427Y|CDH23_uc001jry.2_Silent_p.Y43Y|CDH23_uc001jrz.2_Silent_p.Y43Y	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	427	Cadherin 4.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						TGGACCGCTACGACTTTGATG	0.587													17	2					0	0	0	0	T	73405728	T	T	73405728	2	4	107	1	0	0	0	0	0	0	0	1	3123	547	19	1		1	CDH23	10	73405728	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08		73405728	62129019	106	20006											
AGAP5	729092	broad.mit.edu	37	chr10	75435138	75435138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcatcccgctcctcatacGtcgtggcttcaaagtgccat	8	10	9	14	3	2	0	2	0	0	0	5	0	4	0	3	2	2	3	3	2	2	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr10:75435138G>A	uc009xri.2	-	8	1321	c.1280C>T	c.(1279-1281)ACG>ATG	p.T427M	AGAP5_uc001juu.3_Missense_Mutation_p.T388M	NM_001144000	NP_001137472	A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	427	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						CTCCTCATACGTCGTGGCTTC	0.512													125	30					0	0	0	0	A	75435138	A	A	75435138	3	1	107	1	0	0	0	0	1	0	0	0	371	1145	40	1	784	1	AGAP5	10	75435138	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	2029410	75435138	60099609	107	20007											
PIK3AP1	118788	broad.mit.edu	37	chr10	98469638	98469638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgagtcagtatcttctggCtgcggacctgccgactggac	6	11	13	11	2	3	1	1	1	2	0	3	4	3	3	2	3	2	2	2	3	1	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr10:98469638C>T	uc001kmq.2	-	2	244	c.116G>A	c.(115-117)AGC>AAC	p.S39N		NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	39						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		TATCTTCTGGCTGCGGACCTG	0.622													20	16					0	0	0	0	T	98469638	T	T	98469638	3	4	107	1	0	0	0	0	1	0	0	0	11963	797	28	4	2365	4	PIK3AP1	10	98469638	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	23034500	98469638	37065109	108	20008											
ATRNL1	26033	broad.mit.edu	37	chr10	117001476	117001476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacttccttgagtaacggtgCaaaatgtttttctgccgatt	9	15	8	9	2	1	1	0	1	1	0	2	2	2	1	2	1	3	3	2	1	3	6			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr10:117001476C>T	uc001lcg.2	+	10	2035	c.1649C>T	c.(1648-1650)GCA>GTA	p.A550V		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	550	Kelch 5.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGTAACGGTGCAAAATGTTTT	0.363													28	3					0	0	0	0	T	117001476	T	T	117001476	3	4	107	1	0	0	0	0	1	0	0	0	1209	710	25	4	1687	4	ATRNL1	10	117001476	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	18531838	117001476	18533271	109	20009											
MGMT	4255	broad.mit.edu	37	chr10	131565232	131565232	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaagggagcgggagctaccTcgggctccccgcctgctggc	5	6	15	15	3	1	0	1	0	0	0	3	2	2	2	4	4	4	3	4	4	2	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr10:131565232T>G	uc001lkh.2	+	5	714	c.688T>G	c.(688-690)TCG>GCG	p.S230A		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	199										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		GGGAGCTACCTCGGGCTCCCC	0.637								Direct_reversal_of_damage					9	31					0	0	0	0	G	131565232	G	G	131565232	3	3	107	1	0	0	0	0	1	0	0	0	9610	1551	54	5	706	5	MGMT	10	131565232	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	14563756	131565232	3969515	110	20010											
OR56A1	120796	broad.mit.edu	37	chr11	6048216	6048216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcagggccttcactgccGccccctctgctttgaatcta	5	12	8	16	1	4	1	2	1	2	0	4	1	4	1	4	1	3	2	4	1	2	3	rs139301829		TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr11:6048216G>A	uc010qzw.1	-	1	719	c.719C>T	c.(718-720)GCG>GTG	p.A240V		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	240	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCACTGCCGCCCCCTCTGC	0.498													27	20					0	0	0	0	A	6048216	A	A	6048216	3	1	107	1	0	0	0	0	1	0	0	0	11187	1087	38	1	241	1	OR56A1	11	6048216	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08		6048216	128958300	111	20011											
MMP20	9313	broad.mit.edu	37	chr11	102479679	102479679	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatcttaccgtataatgccTggatccctttcacatcatct	10	15	4	12	1	4	0	2	0	2	0	5	1	5	1	3	1	2	1	3	1	4	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr11:102479679T>G	uc001phc.2	-	5	813	c.800A>C	c.(799-801)CAG>CCG	p.Q267P		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	267					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GTATAATGCCTGGATCCCTTT	0.433													23	67					0	0	0	0	G	102479679	G	G	102479679	3	3	107	1	0	0	0	0	1	0	0	0	9712	1580	55	5	675	5	MMP20	11	102479679	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	96431463	102479679	32526837	112	20012											
USP28	57646	broad.mit.edu	37	chr11	113712437	113712437	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggagactccagtagactcaAagcaatggcagcctgaagat	14	6	12	9	0	1	4	1	1	0	3	2	5	2	4	2	2	2	3	2	2	4	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr11:113712437A>G	uc001poh.2	-	4	355	c.322T>C	c.(322-324)TTG>CTG	p.L108L	USP28_uc010rwy.1_5'UTR|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Silent_p.L108L|USP28_uc010rwz.1_Silent_p.L108L	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	108	UIM.				cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		AGTAGACTCAAAGCAATGGCA	0.348													55	48					0	0	0	0	G	113712437	G	G	113712437	2	3	107	1	0	0	0	0	0	0	0	1	17126	11	1	5		5	USP28	11	113712437	Silent	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	11232758	113712437	21294079	113	20013											
ABCG4	64137	broad.mit.edu	37	chr11	119027587	119027587	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	actctgtgtccccagtcatcGaggtggcctctggcgagtat	6	11	12	12	2	3	0	1	0	2	0	5	2	4	0	3	3	0	1	3	3	1	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr11:119027587G>C	uc001pvs.2	+	9	1267	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	ABCG4_uc009zar.2_Missense_Mutation_p.E311Q	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	311	Cytoplasmic (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CCCAGTCATCGAGGTGGCCTC	0.577													21	101					0	0	0	0	C	119027587	C	C	119027587	3	2	107	1	0	0	0	0	1	0	0	0	70	1059	37	3	961	3	ABCG4	11	119027587	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	5315150	119027587	15978929	114	20014											
TECTA	7007	broad.mit.edu	37	chr11	121016697	121016697	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccccaccttcttctataagaActgcctgtttgactcttgca	8	14	5	14	0	3	2	0	1	3	1	3	2	3	2	4	0	3	2	4	0	3	6			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr11:121016697A>G	uc010rzo.1	+	11	3977	c.3977A>G	c.(3976-3978)AAC>AGC	p.N1326S		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1326					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TTCTATAAGAACTGCCTGTTT	0.567													73	103					0	0	0	0	G	121016697	G	G	121016697	3	3	107	1	0	0	0	0	1	0	0	0	15813	43	2	5	4019	5	TECTA	11	121016697	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	1989110	121016697	13989819	115	20015											
IFFO1	25900	broad.mit.edu	37	chr12	6659050	6659050	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcctggatcttggtgtccaGctccgacaggttctgtccag	5	12	11	13	1	2	0	0	0	2	0	6	2	6	1	4	3	1	2	4	3	0	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:6659050G>T	uc001qpd.1	-	4	977	c.943C>A	c.(943-945)CTG>ATG	p.L315M	IFFO1_uc001qoy.2_RNA|IFFO1_uc001qpa.1_5'Flank|IFFO1_uc001qpb.1_Translation_Start_Site|IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_Missense_Mutation_p.L315M|IFFO1_uc001qpf.1_Missense_Mutation_p.L315M|IFFO1_uc001qoz.1_5'Flank|IFFO1_uc001qpc.1_Missense_Mutation_p.L315M|IFFO1_uc001qpg.2_5'Flank	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	315						intermediate filament					0						TTGGTGTCCAGCTCCGACAGG	0.587													9	9					1.12685e-05	1.31466e-05	1	0	T	6659050	T	T	6659050	3	4	107	1	0	0	0	0	1	0	0	0	7549	962	34	4	776	4	IFFO1	12	6659050	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08		6659050	127192845	116	20016											
SLCO1B1	10599	broad.mit.edu	37	chr12	21325613	21325613	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcagctctgtcactcagcttTattgctaagacactaggtgc	9	12	9	11	0	3	1	2	0	1	1	3	1	3	1	0	1	4	4	0	1	3	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:21325613T>C	uc001req.3	+	3	218	c.114T>C	c.(112-114)TTT>TTC	p.F38F		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	38	Helical; Name=1; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CACTCAGCTTTATTGCTAAGA	0.368													11	58					0	0	0	0	C	21325613	C	C	21325613	2	2	107	1	0	0	0	0	0	0	0	1	14787	1751	61	5		5	SLCO1B1	12	21325613	Silent	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	14666563	21325613	112526282	117	20017											
C12orf72	254013	broad.mit.edu	37	chr12	31820646	31820646	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atccttttcctattttaatcCaaaacattttgaatttggaa	13	18	3	7	0	0	1	0	1	0	0	3	2	3	2	3	1	1	0	3	1	6	8			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:31820646C>T	uc009zjr.2	+	4	720	c.511C>T	c.(511-513)CAA>TAA	p.Q171*	C12orf72_uc001rkl.2_Nonsense_Mutation_p.Q171*|C12orf72_uc001rkm.2_Nonsense_Mutation_p.Q171*	NM_001135864	NP_001129336	Q8IXQ9	MET20_HUMAN	hypothetical protein LOC254013	171						cytoplasm	protein methyltransferase activity				0						TATTTTAATCCAAAACATTTT	0.328													25	19					0	0	0	0	T	31820646	T	T	31820646	4	4	107	1	0	0	0	0	0	1	0	0	1719	595	21	4	521	4	C12orf72	12	31820646	Nonsense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	10495033	31820646	102031249	118	20018											
PRICKLE1	144165	broad.mit.edu	37	chr12	42858530	42858530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtgctcactggctcgaatatCcatctcattgggctgtggct	6	13	11	11	1	2	0	2	0	1	0	5	1	3	0	1	3	1	4	1	3	2	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:42858530C>G	uc010skv.1	-	7	1593	c.1306G>C	c.(1306-1308)GAT>CAT	p.D436H	PRICKLE1_uc001rnl.2_Missense_Mutation_p.D436H|PRICKLE1_uc010skw.1_Missense_Mutation_p.D436H|PRICKLE1_uc001rnm.2_Missense_Mutation_p.D436H	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	436					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GCTCGAATATCCATCTCATTG	0.423													25	52					0	0	0	0	G	42858530	G	G	42858530	3	3	107	1	0	0	0	0	1	0	0	0	12548	855	30	2	1197	2	PRICKLE1	12	42858530	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	11037884	42858530	90993365	119	20019											
MLL2	8085	broad.mit.edu	37	chr12	49425072	49425073	+	Frame_Shift_Del	DEL	CA	-	-																															ccccgcccagtgctgagttgCacattctttgcccggagtag																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:49425072_49425073delCA	uc001rta.3	-	39	13415_13416	c.13415_13416delTG	c.(13414-13416)GTGfs	p.V4472fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4472					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGCTGAGTTGCACATTCTTTGC	0.614			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								-	49425073	-	-	49425072	7	5	107	1	0	1	0	1	0	0	0	0	9674	697	25	0	3261	0	MLL2	12	49425072	Frame_Shift_Del	DEL	CA	TCGA-CQ-6225-01A-11D-1912-08	6566542	49425072	84426823	120	20020											
MLL2	8085	broad.mit.edu	37	chr12	49448535	49448535	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgccgcaccggacccccaCtgtggacacacaagcatcag	12	3	9	17	3	1	0	1	0	0	0	1	2	1	2	4	2	2	2	4	2	2	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:49448535C>T	uc001rta.3	-	3	177	c.177_splice	c.e3-1	p.S59_splice		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2						chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CGGACCCCCACTGTGGACACA	0.587			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			29	18					0	0	0	0	T	49448535	T	T	49448535	5	4	107	1	0	0	0	0	0	0	1	0	9674	579	20	4	16645	4	MLL2	12	49448535	Splice_Site	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	23463	49448535	84403360	121	20021											
OR6C2	341416	broad.mit.edu	37	chr12	55846799	55846802	+	Frame_Shift_Del	DEL	ATAA	-	-																															ctgcaaaagatgaggtggccAtaaataaaggagtttcagtt																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:55846799_55846802delATAA	uc001sgz.1	+	1	802_805	c.802_805delATAA	c.(802-807)ATAAATfs	p.I268fs		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	268_269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TGAGGTGGCCATAAATAAAGGAGT	0.436													---	---	---								-	55846802	-	-	55846799	7	5	107	1	0	1	0	1	0	0	0	0	11245	217	8	0	804	0	OR6C2	12	55846799	Frame_Shift_Del	DEL	ATAA	TCGA-CQ-6225-01A-11D-1912-08	6398264	55846799	78005096	122	20022											
CAND1	55832	broad.mit.edu	37	chr12	67699816	67699816	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttactctcagagcacagctCttactcataagcagtcttat	11	14	5	11	0	4	1	2	0	3	1	5	1	4	1	0	0	5	3	0	0	4	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:67699816C>G	uc001stn.2	+	10	2805	c.2368C>G	c.(2368-2370)CTT>GTT	p.L790V	CAND1_uc001sto.2_Missense_Mutation_p.L300V	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	790	HEAT 18.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		GAGCACAGCTCTTACTCATAA	0.433													50	44					0	0	0	0	G	67699816	G	G	67699816	3	3	107	1	0	0	0	0	1	0	0	0	2627	913	32	2	2406	2	CAND1	12	67699816	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	11853017	67699816	66152079	123	20023											
ACSS3	79611	broad.mit.edu	37	chr12	81532986	81532986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtaccacttgtagaagaagCgctaaaaataggacaacaca	18	6	8	9	2	0	2	0	0	0	2	0	3	0	3	1	1	3	3	1	1	9	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:81532986C>T	uc001szl.1	+	4	813	c.722C>T	c.(721-723)GCG>GTG	p.A241V	ACSS3_uc001szm.1_Missense_Mutation_p.A240V	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	241						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GTAGAAGAAGCGCTAAAAATA	0.353													24	13					0	0	0	0	T	81532986	T	T	81532986	3	4	107	1	0	0	0	0	1	0	0	0	190	768	27	1	736	1	ACSS3	12	81532986	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	13833170	81532986	52318909	124	20024											
SLC41A2	84102	broad.mit.edu	37	chr12	105238389	105238389	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtagaacttgagcagacttaTtatttactcctgtaatataa	14	15	6	6	0	0	3	0	1	0	2	1	3	1	3	1	0	3	3	1	0	8	9			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:105238389T>A	uc001tla.2	-	9	1564	c.1397A>T	c.(1396-1398)AAT>ATT	p.N466I		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	466	Extracellular.					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						AGCAGACTTATTATTTACTCC	0.254													4	58					0	0	0	0	A	105238389	A	A	105238389	3	1	107	1	0	0	0	0	1	0	0	0	14694	1493	52	5	332	5	SLC41A2	12	105238389	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	23705403	105238389	28613506	125	20025											
PLBD2	196463	broad.mit.edu	37	chr12	113810606	113810606	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aacccagactcaccttactgGcaccaggtgagtcctgctgc	9	8	9	15	0	1	2	1	1	0	1	2	2	2	2	4	2	4	2	4	2	2	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:113810606G>C	uc001tve.2	+	3	572	c.537G>C	c.(535-537)TGG>TGC	p.W179C	PLBD2_uc001tvf.2_Missense_Mutation_p.W179C	NM_173542	NP_775813	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2 isoform 1	179					lipid catabolic process	lysosomal lumen	hydrolase activity				0						CACCTTACTGGCACCAGGTGA	0.587													36	29					0	0	0	0	C	113810606	C	C	113810606	3	2	107	1	0	0	0	0	1	0	0	0	12081	1212	42	4	547	4	PLBD2	12	113810606	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	8572217	113810606	20041289	126	20026											
UBC	7316	broad.mit.edu	37	chr12	125397972	125397972	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcaaagatcaacctctgctGgtcaggaggaatgccttcct	10	9	11	11	0	3	1	2	0	1	1	4	3	4	3	3	4	3	2	3	4	3	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr12:125397972G>A	uc001ugs.3	-	2	794	c.346C>T	c.(346-348)CAG>TAG	p.Q116*	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Nonsense_Mutation_p.Q116*|UBC_uc001ugt.2_Nonsense_Mutation_p.Q116*|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_5'UTR	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	116	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		AACCTCTGCTGGTCAGGAGGA	0.547													41	129					0	0	0	0	A	125397972	A	A	125397972	4	1	107	1	0	0	0	0	0	1	0	0	16910	1357	47	4	1715	4	UBC	12	125397972	Nonsense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	11587366	125397972	8453923	127	20027											
KIAA0831	22863	broad.mit.edu	37	chr14	55878478	55878478	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccaccaggtcccgggcgagCggccggggcccgcagccagg	5	2	17	17	5	0	0	0	0	0	0	2	1	2	0	6	6	2	1	6	6	0	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr14:55878478C>A	uc001xbx.1	-	1	99	c.63G>T	c.(61-63)CCG>CCT	p.P21P	FBXO34_uc001xbv.2_Intron	NM_014924	NP_055739	Q6ZNE5	BAKOR_HUMAN	Barkor	21					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding				0						CCCGGGCGAGCGGCCGGGGCC	0.701													7	8					8.12818e-05	9.33699e-05	1	0	A	55878478	A	A	55878478	2	1	107	1	0	0	0	0	0	0	0	1	8234	755	27	3		3	KIAA0831	14	55878478	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08		55878478	51471062	128	20028											
ADCK1	57143	broad.mit.edu	37	chr14	78325478	78325478	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgccaaccggggcaccttCatcaaggtgggccagcacct	8	7	12	14	1	2	0	2	0	0	0	2	0	2	0	5	4	3	2	5	4	2	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr14:78325478C>A	uc001xui.2	+	4	378	c.279C>A	c.(277-279)TTC>TTA	p.F93L	ADCK1_uc010tvo.1_RNA|ADCK1_uc001xuj.2_Intron|ADCK1_uc001xuk.1_5'UTR	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	100						extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		GGGGCACCTTCATCAAGGTGG	0.622													51	48					9.52127e-25	1.19818e-24	1	0	A	78325478	A	A	78325478	3	1	107	1	0	0	0	0	1	0	0	0	288	825	29	2	289	2	ADCK1	14	78325478	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	22447000	78325478	29024062	129	20029											
EML5	161436	broad.mit.edu	37	chr14	89082514	89082514	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcacctccagcactaacaaCatgtcgatcaccactggtaa	14	8	5	14	1	2	0	2	0	0	0	4	1	3	0	3	1	3	2	3	1	3	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr14:89082514C>T	uc001xxg.2	-	43	6055	c.5869G>A	c.(5869-5871)GTT>ATT	p.V1957I	EML5_uc001xxf.2_Missense_Mutation_p.V744I|EML5_uc001xxd.2_Missense_Mutation_p.V122I|EML5_uc001xxe.2_Missense_Mutation_p.V306I	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1949	WD 29.					cytoplasm|microtubule				ovary(3)	3						GCACTAACAACATGTCGATCA	0.418													53	81					0	0	0	0	T	89082514	T	T	89082514	3	4	107	1	0	0	0	0	1	0	0	0	5124	478	17	4	72	4	EML5	14	89082514	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	10757036	89082514	18267026	130	20030											
MOAP1	64112	broad.mit.edu	37	chr14	93649974	93649974	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgaaggctctctagcaatCgccttctcttctctacatct	7	14	5	15	2	4	0	0	0	4	0	9	1	4	0	1	1	2	2	1	1	4	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr14:93649974C>A	uc001ybj.2	-	3	984	c.614G>T	c.(613-615)CGA>CTA	p.R205L	C14orf109_uc001ybk.3_5'Flank|C14orf109_uc010auo.2_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	205	RASSF1-binding.			KRRR->AAAA: Loss of RASSF1-binding; interacts with BAX in the absence of RASSF1.	activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			skin(2)|ovary(1)	3		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		ctctagcaatcgccttctctt	0													25	72					3.6726e-16	4.42292e-16	1	0	A	93649974	A	A	93649974	3	1	107	1	0	0	0	0	1	0	0	0	9733	884	31	3	445	3	MOAP1	14	93649974	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	4567460	93649974	13699566	131	20031											
CYP46A1	10858	broad.mit.edu	37	chr14	100182184	100182184	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagcagctccgggaggtccGggagagcattcgcttcctgc	7	7	15	12	3	0	1	0	0	0	1	4	4	3	2	3	3	4	4	3	3	1	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr14:100182184G>A	uc001ygo.2	+	8	731	c.731G>A	c.(730-732)CGG>CAG	p.R244Q	CYP46A1_uc001ygp.2_Missense_Mutation_p.R91Q	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	244					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CGGGAGGTCCGGGAGAGCATT	0.632													26	38					0	0	0	0	A	100182184	A	A	100182184	3	1	107	1	0	0	0	0	1	0	0	0	4199	1116	39	1	761	1	CYP46A1	14	100182184	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	6532210	100182184	7167356	132	20032											
HERC2	8924	broad.mit.edu	37	chr15	28413737	28413737	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggccccgacaacagcatctCtgtcaggacacaaagccagg	12	4	11	14	1	2	0	1	0	1	0	3	2	2	1	3	3	3	1	3	3	2	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr15:28413737C>G	uc001zbj.2	-	67	10336	c.10230_splice	c.e67-1	p.R3410_splice		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AACAGCATCTCTGTCAGGACA	0.647													12	14					0	0	0	0	G	28413737	G	G	28413737	5	3	107	1	0	0	0	0	0	0	1	0	7097	927	32	2	4383	2	HERC2	15	28413737	Splice_Site	SNP	C	TCGA-CQ-6225-01A-11D-1912-08		28413737	74117655	133	20033											
TRPM1	4308	broad.mit.edu	37	chr15	31354781	31354781	+	Splice_Site	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaataaattcaagacacttaCgagttctttcttcttcatgc	13	15	4	9	1	5	1	2	0	3	1	5	2	5	1	0	0	2	1	0	0	5	7			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr15:31354781C>G	uc001zfm.2	-	8	1151	c.1023_splice	c.e8+1	p.L341_splice	TRPM1_uc010azy.2_Splice_Site_p.L248_splice|TRPM1_uc001zfl.2_Splice_Site	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,						cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AAGACACTTACGAGTTCTTTC	0.348													4	94					0	0	0	0	G	31354781	G	G	31354781	5	3	107	1	0	0	0	0	0	0	1	0	16652	550	19	3	3867	3	TRPM1	15	31354781	Splice_Site	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	2941044	31354781	71176611	134	20034											
SLC12A1	6557	broad.mit.edu	37	chr15	48500015	48500015	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgagaaccatgagagcagTgcagctgcagatgacaatac	16	6	11	8	0	0	4	0	3	0	3	0	6	0	4	1	0	6	4	1	0	4	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr15:48500015T>C	uc001zwn.3	+	2	315	c.99T>C	c.(97-99)AGT>AGC	p.S33S	SLC12A1_uc010uew.1_Intron|SLC12A1_uc010bem.2_Silent_p.S33S|SLC12A1_uc010uex.1_Silent_p.S33S	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	33	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	ATGAGAGCAGTGCAGCTGCAG	0.428													17	22					0	0	0	0	C	48500015	C	C	48500015	2	2	107	1	0	0	0	0	0	0	0	1	14447	1693	59	5		5	SLC12A1	15	48500015	Silent	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	17145234	48500015	54031377	135	20035											
DMXL2	23312	broad.mit.edu	37	chr15	51809332	51809333	+	Missense_Mutation	DNP	GC	AT	AT																															ggtcgagcagtagactgttgGctcacaatattaaacacttc																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr15:51809332_51809333GC>AT	uc002abf.2	-	14	2693_2694	c.2468_2469GC>AT	c.(2467-2469)AGC>AAT	p.S823N	DMXL2_uc010ufy.1_Missense_Mutation_p.S823N|DMXL2_uc010bfa.2_Missense_Mutation_p.S823N	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	823						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TAGACTGTTGGCTCACAATATT	0.337													6	136					0	0	0	0	AT	51809333	AT	AT	51809332	3	1	107	1	0	0	0	0	1	0	0	0	4617	1194	42	4	6764	4	DMXL2	15	51809332	Missense_Mutation	DNP	GC	TCGA-CQ-6225-01A-11D-1912-08	3309317	51809332	50722060	136	20036											
UNC13C	440279	broad.mit.edu	37	chr15	54305278	54305278	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaaattttcttacacttttAaaagcactgtaaagaagatt	16	14	4	7	0	1	2	0	0	1	2	1	2	1	2	1	0	2	2	1	0	7	7			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr15:54305278A>T	uc002ack.2	+	1	178	c.178A>T	c.(178-180)AAA>TAA	p.K60*		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	60					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TTACACTTTTAAAAGCACTGT	0.418													37	51					0	0	0	0	T	54305278	T	T	54305278	4	4	107	1	0	0	0	0	0	1	0	0	17054	363	13	5	180	5	UNC13C	15	54305278	Nonsense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	2495946	54305278	48226114	137	20037											
RFX7	64864	broad.mit.edu	37	chr15	56386608	56386608	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtctggattgagactgataAgactgtccaggcacagcaaa	13	9	11	8	0	1	3	0	2	1	2	2	5	2	4	1	2	1	2	1	2	2	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr15:56386608A>C	uc010bfn.2	-	9	3318	c.3318T>G	c.(3316-3318)TCT>TCG	p.S1106S	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Silent_p.S920S	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	1009					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						GAGACTGATAAGACTGTCCAG	0.448													35	88					0	0	0	0	C	56386608	C	C	56386608	2	2	107	1	0	0	0	0	0	0	0	1	13333	59	3	5		5	RFX7	15	56386608	Silent	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	2081330	56386608	46144784	138	20038											
LARP6	55323	broad.mit.edu	37	chr15	71125421	71125421	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgaatacttcaaagcatgtGctgtggttctccagtcccgt	8	13	9	11	1	2	1	1	1	1	0	4	1	3	1	2	1	3	3	2	1	3	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr15:71125421G>T	uc002ass.2	-	3	517	c.446C>A	c.(445-447)GCA>GAA	p.A149E		NM_018357	NP_060827	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	149	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0						CAAAGCATGTGCTGTGGTTCT	0.483													36	65					2.75727e-19	3.41232e-19	1	0	T	71125421	T	T	71125421	3	4	107	1	0	0	0	0	1	0	0	0	8672	1319	46	4	1033	4	LARP6	15	71125421	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	14738813	71125421	31405971	139	20039											
DECR2	26063	broad.mit.edu	37	chr16	457468	457471	+	Frame_Shift_Del	DEL	CTCT	-	-																															caccggccggcgctgcctccCtctctctatggacgtccgag																								rs145497745		TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr16:457468_457471delCTCT	uc002chb.2	+	4	351_354	c.245_248delCTCT	c.(244-249)CCTCTCfs	p.P82fs	DECR2_uc002chc.2_5'UTR|DECR2_uc010bqv.2_5'UTR|DECR2_uc002chd.2_5'UTR|DECR2_uc002che.1_RNA	NM_020664	NP_065715	Q9NUI1	DECR2_HUMAN	2,4-dienoyl CoA reductase 2	82_83						peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity|binding				0		Hepatocellular(16;0.00015)				CGCTGCCTCCCTCTCTCTATGGAC	0.632													---	---	---								-	457471	-	-	457468	7	5	107	1	0	1	0	1	0	0	0	0	4400	681	24	0	259	0	DECR2	16	457468	Frame_Shift_Del	DEL	CTCT	TCGA-CQ-6225-01A-11D-1912-08		457468	89897285	140	20040											
SCNN1B	6338	broad.mit.edu	37	chr16	23382771	23382771	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcggggacagagacgtccatCggggtactcgtggtatggcc	7	8	16	10	4	0	1	0	0	0	1	4	3	1	2	2	6	1	2	2	6	2	2	rs148438164	byFrequency	TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr16:23382771C>T	uc002dln.2	+	6	1208	c.1032C>T	c.(1030-1032)ATC>ATT	p.I344I		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	344	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	AGACGTCCATCGGGGTACTCG	0.642													9	23					0	0	0	0	T	23382771	T	T	23382771	2	4	107	1	0	0	0	0	0	0	0	1	13993	874	31	1		1	SCNN1B	16	23382771	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	22925303	23382771	66971982	141	20041											
ARHGAP17	55114	broad.mit.edu	37	chr16	24990293	24990293	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctatattttgttacctgtaaTagatcttcactaaggacttc	11	17	5	8	0	2	1	1	0	1	1	3	2	2	2	1	1	1	2	1	1	6	10			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr16:24990293T>C	uc002dnb.2	-	2	180	c.87A>G	c.(85-87)CTA>CTG	p.L29L	ARHGAP17_uc002dnc.2_Silent_p.L29L|ARHGAP17_uc010vcf.1_Intron|ARHGAP17_uc002dng.1_Silent_p.L29L	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	29	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		TTACCTGTAATAGATCTTCAC	0.303													12	19					0	0	0	0	C	24990293	C	C	24990293	2	2	107	1	0	0	0	0	0	0	0	1	867	1393	49	5		5	ARHGAP17	16	24990293	Silent	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	1607522	24990293	65364460	142	20042											
ZNF629	23361	broad.mit.edu	37	chr16	30793689	30793689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggaggacagcagcccccGcctctggctgaagccctcct	6	7	11	17	1	1	1	0	1	1	0	2	3	2	3	5	3	3	2	5	3	1	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr16:30793689G>A	uc002dzs.1	-	3	2168	c.1960C>T	c.(1960-1962)CGG>TGG	p.R654W		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	654					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			AGCAGCCCCCGCCTCTGGCTG	0.657													3	7					0	0	0	0	A	30793689	A	A	30793689	3	1	107	1	0	0	0	0	1	0	0	0	18120	1086	38	1	653	1	ZNF629	16	30793689	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	5803396	30793689	59561064	143	20043											
PLLP	51090	broad.mit.edu	37	chr16	57290897	57290897	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgccaggcctggtagctgaaGaaggcactcactccataggc	10	6	12	13	1	1	2	1	1	0	1	2	2	2	2	3	4	1	3	3	4	4	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr16:57290897G>A	uc002elg.1	-	4	605	c.477C>T	c.(475-477)TTC>TTT	p.F159F		NM_015993	NP_057077	Q9Y342	PLLP_HUMAN	plasmolipin	159	Helical; (Potential).|MARVEL.					integral to membrane	ion channel activity				0						GGTAGCTGAAGAAGGCACTCA	0.582													36	32					0	0	0	0	A	57290897	A	A	57290897	2	1	107	1	0	0	0	0	0	0	0	1	12154	933	33	2		2	PLLP	16	57290897	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	26497208	57290897	33063856	144	20044											
DOK4	55715	broad.mit.edu	37	chr16	57509863	57509863	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaacaccagccagcacctccGgtagatctgtggagcgagat	11	6	12	12	2	1	2	0	0	1	2	2	5	2	3	4	2	4	2	4	2	2	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr16:57509863G>A	uc010cdb.2	-	2	371	c.73C>T	c.(73-75)CGG>TGG	p.R25W	DOK4_uc002elu.1_Missense_Mutation_p.R25W|DOK4_uc002elv.3_Missense_Mutation_p.R25W	NM_018110	NP_060580	Q8TEW6	DOK4_HUMAN	docking protein 4	25	PH.						insulin receptor binding			skin(1)	1						CAGCACCTCCGGTAGATCTGT	0.667													10	10					0	0	0	0	A	57509863	A	A	57509863	3	1	107	1	0	0	0	0	1	0	0	0	4721	1115	39	1	935	1	DOK4	16	57509863	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	218966	57509863	32844890	145	20045											
TP53	7157	broad.mit.edu	37	chr17	7578403	7578403	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagcgctcatggtgggggCagcgcctcacaacctccgtc	7	6	13	15	3	2	0	2	0	0	0	4	0	3	0	3	3	4	3	3	3	1	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr17:7578403C>G	uc002gim.2	-	5	721	c.527G>C	c.(526-528)TGC>TCC	p.C176S	TP53_uc002gig.1_Missense_Mutation_p.C176S|TP53_uc002gih.2_Missense_Mutation_p.C176S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C44S|TP53_uc010cng.1_Missense_Mutation_p.C44S|TP53_uc002gii.1_Missense_Mutation_p.C44S|TP53_uc010cnh.1_Missense_Mutation_p.C176S|TP53_uc010cni.1_Missense_Mutation_p.C176S|TP53_uc002gij.2_Missense_Mutation_p.C176S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C83S|TP53_uc002gio.2_Missense_Mutation_p.C44S|TP53_uc010vug.1_Missense_Mutation_p.C137S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	176	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	CP -> FS (in a sporadic cancer; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C176F(102)|p.C176Y(56)|p.C176S(19)|p.C176W(11)|p.C176R(8)|p.C176fs*71(7)|p.0?(7)|p.C176*(6)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.C176G(3)|p.C176fs*5(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.C44Y(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R42fs*24(1)|p.C83Y(1)|p.C176fs*72(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.C176del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.C176fs*6(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGTGGGGGCAGCGCCTCAC	0.652		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	8					0	0	0	0	G	7578403	G	G	7578403	3	3	107	1	0	0	0	0	1	0	0	0	16448	710	25	4	771	4	TP53	17	7578403	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08		7578403	73616807	146	20046											
PFAS	5198	broad.mit.edu	37	chr17	8172074	8172074	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacaacctgtctgggcgctaCgagtctcgctgggccagcgt	6	8	13	14	4	2	0	0	0	2	0	3	1	2	0	2	2	3	2	2	2	2	1	rs150119860		TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr17:8172074C>T	uc002gkr.2	+	27	3747	c.3606C>T	c.(3604-3606)TAC>TAT	p.Y1202Y	PFAS_uc010vuv.1_Silent_p.Y778Y|PFAS_uc002gks.2_Silent_p.Y281Y	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	1202	Glutamine amidotransferase type-1.				'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTGGGCGCTACGAGTCTCGCT	0.701													38	5					0	0	0	0	T	8172074	T	T	8172074	2	4	107	1	0	0	0	0	0	0	0	1	11809	547	19	1		1	PFAS	17	8172074	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	593671	8172074	73023136	147	20047											
KRT33A	3883	broad.mit.edu	37	chr17	39504890	39504890	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagggacagctcggtctcatAtctgtgatcacaggagggtc	9	9	13	10	1	3	1	2	1	2	0	6	3	3	3	0	4	1	1	0	4	1	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr17:39504890A>G	uc002hwk.1	-	3	470	c.433T>C	c.(433-435)TAT>CAT	p.Y145H		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	145	Rod.|Coil 1B.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				TCGGTCTCATATCTGTGATCA	0.572													158	42					0	0	0	0	G	39504890	G	G	39504890	3	3	107	1	0	0	0	0	1	0	0	0	8508	463	16	5	801	5	KRT33A	17	39504890	Missense_Mutation	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	31332816	39504890	41690320	148	20048											
TBKBP1	9755	broad.mit.edu	37	chr17	45774515	45774516	+	Frame_Shift_Del	DEL	CT	-	-																															tgatccaggcctacgagaaaCtctgcgtggagaagagtgac																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr17:45774515_45774516delCT	uc002ilu.2	+	3	1258_1259	c.409_410delCT	c.(409-411)CTCfs	p.L137fs		NM_014726	NP_055541	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	137	Potential.				innate immune response						0						CTACGAGAAACTCTGCGTGGAG	0.569													---	---	---								-	45774516	-	-	45774515	7	5	107	1	0	1	0	1	0	0	0	0	15704	565	20	0	419	0	TBKBP1	17	45774515	Frame_Shift_Del	DEL	CT	TCGA-CQ-6225-01A-11D-1912-08	6269625	45774515	35420695	149	20049											
EME1	146956	broad.mit.edu	37	chr17	48453432	48453432	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttccatctgttgcagtgctcTtacagatggaaggtgggggc	7	12	14	8	0	2	1	0	0	2	1	3	2	3	2	1	4	3	3	1	4	2	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr17:48453432T>G	uc002iqs.1	+	3	854	c.781T>G	c.(781-783)TTA>GTA	p.L261V	MRPL27_uc002iqq.2_5'Flank|MRPL27_uc002iqr.2_5'Flank|EME1_uc010dbp.1_Missense_Mutation_p.L261V	NM_152463	NP_689676	Q96AY2	EME1_HUMAN	essential meiotic endonuclease 1 homolog 1	261					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding				0	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			TGCAGTGCTCTTACAGATGGA	0.567								Direct_reversal_of_damage|Homologous_recombination					5	73					0	0	0	0	G	48453432	G	G	48453432	3	3	107	1	0	0	0	0	1	0	0	0	5112	1606	56	5	787	5	EME1	17	48453432	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	2678917	48453432	32741778	150	20050											
SPAG9	9043	broad.mit.edu	37	chr17	49074037	49074037	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttttgttctctgcgtgaGgctaaactagcttcagttct	6	17	8	10	1	4	1	1	1	3	0	5	1	4	1	0	1	3	4	0	1	3	7			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr17:49074037G>T	uc002itc.2	-	16	2066	c.1857C>A	c.(1855-1857)GCC>GCA	p.A619A	SPAG9_uc002itb.2_Silent_p.A605A|SPAG9_uc002itd.2_Silent_p.A609A|SPAG9_uc002itf.2_Silent_p.A440A|SPAG9_uc002ita.2_Silent_p.A462A|SPAG9_uc002ite.2_Silent_p.A449A	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	619					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			CTCTGCGTGAGGCTAAACTAG	0.408													18	29					4.63292e-17	5.64008e-17	1	0	T	49074037	T	T	49074037	2	4	107	1	0	0	0	0	0	0	0	1	15051	987	35	4		4	SPAG9	17	49074037	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	620605	49074037	32121173	151	20051											
STXBP4	252983	broad.mit.edu	37	chr17	53111543	53111543	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttagattttgtccaggttGccagaaacttgttttgcttg	7	19	9	6	0	0	2	0	0	0	2	1	2	1	2	2	1	3	3	2	1	2	9			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr17:53111543G>A	uc002iuf.1	+	10	985	c.778G>A	c.(778-780)GCC>ACC	p.A260T	STXBP4_uc010dcc.1_Missense_Mutation_p.A185T|STXBP4_uc010dcd.1_Missense_Mutation_p.A260T	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	260						cytoplasm	calcium ion binding			ovary(1)	1						TGTCCAGGTTGCCAGAAACTT	0.338													38	52					0	0	0	0	A	53111543	A	A	53111543	3	1	107	1	0	0	0	0	1	0	0	0	15421	1319	46	4	808	4	STXBP4	17	53111543	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	4037506	53111543	28083667	152	20052											
BCAS3	54828	broad.mit.edu	37	chr17	58967054	58967054	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgccatttgaaatttttcAggctgctatccatgtccagg	9	14	9	9	0	1	1	1	1	0	0	3	1	3	1	3	2	2	2	3	2	2	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr17:58967054A>G	uc002iyv.3	+	10	771	c.662_splice	c.e10-2	p.S221_splice	BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Splice_Site_p.S221_splice|BCAS3_uc002iyw.3_Splice_Site_p.S217_splice|BCAS3_uc002iyx.1_Splice_Site_p.G36_splice|BCAS3_uc002iyy.3_Splice_Site	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1							nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			GAAATTTTTCAGGCTGCTATC	0.398													3	118					0	0	0	0	G	58967054	G	G	58967054	5	3	107	1	0	0	0	0	0	0	1	0	1354	202	7	5	694	5	BCAS3	17	58967054	Splice_Site	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	5855511	58967054	22228156	153	20053											
BIRC5	332	broad.mit.edu	37	chr17	76212844	76212844	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttttgaaactggacagagaAagagccaagaacaaaattgt	18	9	9	5	0	0	4	0	1	0	3	0	6	0	5	1	1	3	0	1	1	6	3			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr17:76212844A>G	uc002jvg.2	+	3	442	c.321A>G	c.(319-321)GAA>GAG	p.E107E	BIRC5_uc002jve.1_Intron|BIRC5_uc002jvd.1_Silent_p.E130E|BIRC5_uc010dhk.1_RNA|BIRC5_uc010dhl.1_Silent_p.E155E|BIRC5_uc002jvf.2_Silent_p.E130E|BIRC5_uc002jvh.2_Intron|BIRC5_uc002jvi.2_RNA|EPR1_uc002jvj.1_RNA	NM_001168	NP_001159	O15392	BIRC5_HUMAN	baculoviral IAP repeat-containing protein 5	107					anti-apoptosis|apoptosis|cell division|chromosome segregation|cytokinesis|establishment of chromosome localization|G2/M transition of mitotic cell cycle|mitosis|mitotic prometaphase|positive regulation of exit from mitosis|positive regulation of mitotic cell cycle|protein complex localization|spindle checkpoint	centriole|chromosome passenger complex|chromosome, centromeric region|cytoplasm|cytoplasmic microtubule|cytosol|interphase microtubule organizing center|midbody|midbody|nuclear chromosome|spindle|spindle microtubule	caspase inhibitor activity|chaperone binding|cobalt ion binding|cofactor binding|cysteine-type endopeptidase inhibitor activity|metal ion binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|Ran GTPase binding|zinc ion binding			kidney(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.153)			TGGACAGAGAAAGAGCCAAGA	0.403													30	53					0	0	0	0	G	76212844	G	G	76212844	2	3	107	1	0	0	0	0	0	0	0	1	1440	11	1	5		5	BIRC5	17	76212844	Silent	SNP	A	TCGA-CQ-6225-01A-11D-1912-08	17245790	76212844	4982366	154	20054											
DNAH17	8632	broad.mit.edu	37	chr17	76424609	76424611	+	In_Frame_Del	DEL	CTC	-	-																															agtttcaaagatcctgccttCtcctcgcgggacactcccgt																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr17:76424609_76424611delCTC	uc010dhp.1	-	22	3805_3807	c.3583_3585delGAG	c.(3583-3585)GAGdel	p.E1195del	DNAH17_uc002jvq.2_In_Frame_Del_p.E480del|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATCCTGCCTTCTCCTCGCGGGAC	0.532													---	---	---								-	76424611	-	-	76424609	7	5	107	1	0	1	0	1	0	0	0	0	4623	912	32	0	823	0	DNAH17	17	76424609	In_Frame_Del	DEL	CTC	TCGA-CQ-6225-01A-11D-1912-08	211765	76424609	4770601	155	20055											
RAB12	201475	broad.mit.edu	37	chr18	8633275	8633277	+	In_Frame_Del	DEL	AAG	-	-																															tattagtatatgatatcactAagaaggagacatttgatgat																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr18:8633275_8633277delAAG	uc002knp.2	+	3	659_661	c.376_378delAAG	c.(376-378)AAGdel	p.K127del		NM_001025300	NP_001020471	Q6IQ22	RAB12_HUMAN	RAB12, member RAS oncogene family	127					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding				0						TGATATCACTAAGAAGGAGACAT	0.384													---	---	---								-	8633277	-	-	8633275	7	5	107	1	0	1	0	1	0	0	0	0	12963	363	13	0	386	0	RAB12	18	8633275	In_Frame_Del	DEL	AAG	TCGA-CQ-6225-01A-11D-1912-08		8633275	69443973	156	20056											
RNMT	8731	broad.mit.edu	37	chr18	13737130	13737130	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaattaacaagctagtttgTactggtaagataaataatga	18	12	8	3	0	0	3	0	1	0	2	0	3	0	3	0	1	3	4	0	1	9	7			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr18:13737130T>A	uc002ksk.1	+	4	742	c.675T>A	c.(673-675)TGT>TGA	p.C225*	RNMT_uc002ksl.1_Nonsense_Mutation_p.C225*|RNMT_uc002ksm.1_Nonsense_Mutation_p.C225*|RNMT_uc010dlk.2_Nonsense_Mutation_p.C225*|RNMT_uc010xae.1_RNA	NM_003799	NP_003790	O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	225					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding				0						AGCTAGTTTGTACTGGTAAGA	0.343													17	15					0	0	0	0	A	13737130	A	A	13737130	4	1	107	1	0	0	0	0	0	1	0	0	13571	1644	57	5	685	5	RNMT	18	13737130	Nonsense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	5103855	13737130	64340118	157	20057											
PARD6G	84552	broad.mit.edu	37	chr18	77917976	77917976	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgaagcccgcggtgccgtccGagggcggtcccgagctgccc	4	4	16	17	7	0	0	0	0	0	0	2	3	2	0	5	3	4	1	5	3	1	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr18:77917976G>A	uc002lny.2	-	3	975	c.809C>T	c.(808-810)TCG>TTG	p.S270L	LOC100130522_uc002lnx.2_Intron|LOC100130522_uc010xfn.1_Intron|LOC100130522_uc010xfo.1_Intron	NM_032510	NP_115899	Q9BYG4	PAR6G_HUMAN	PAR-6 gamma protein	270					cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding				0		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)		GGTGCCGTCCGAGGGCGGTCC	0.701													5	5					0	0	0	0	A	77917976	A	A	77917976	3	1	107	1	0	0	0	0	1	0	0	0	11501	1059	37	1	325	1	PARD6G	18	77917976	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	64180846	77917976	159272	158	20058											
CACNA1A	773	broad.mit.edu	37	chr19	13411468	13411468	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcttcttcctcttgctcGtcctaaaaggcacgtggaat	7	14	8	12	2	3	0	0	0	3	0	6	1	5	1	2	2	1	3	2	2	3	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:13411468G>A	uc010dze.2	-	18	2414	c.2178C>T	c.(2176-2178)GAC>GAT	p.D726D	CACNA1A_uc010dzc.2_Silent_p.D251D|CACNA1A_uc002mwy.3_Silent_p.D725D|CACNA1A_uc010xne.1_Silent_p.D254D	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	726	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCTCTTGCTCGTCCTAAAAGG	0.493													5	65					0	0	0	0	A	13411468	A	A	13411468	2	1	107	1	0	0	0	0	0	0	0	1	2550	1136	40	1		1	CACNA1A	19	13411468	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08		13411468	45717515	159	20059											
FAM125A	93343	broad.mit.edu	37	chr19	17535470	17535470	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaccatcaagtctctggCggacattgaggaggaggtgg	9	8	15	9	1	2	2	1	2	1	0	3	5	2	5	2	6	0	0	2	6	1	1	rs143800574		TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:17535470C>T	uc002ngo.1	+	8	776	c.743C>T	c.(742-744)GCG>GTG	p.A248V	FAM125A_uc002ngp.1_Missense_Mutation_p.A156V|FAM125A_uc002ngq.1_Missense_Mutation_p.A144V	NM_138401	NP_612410	Q96EY5	F125A_HUMAN	family with sequence similarity 125, member A	248	UMA.|Interaction with TSG101, VPS37B and VPS28.				protein transport	late endosome membrane|microtubule organizing center|nucleus	SH3 domain binding				0						AAGTCTCTGGCGGACATTGAG	0.662													7	0					0	0	0	0	T	17535470	T	T	17535470	3	4	107	1	0	0	0	0	1	0	0	0	5455	768	27	1	773	1	FAM125A	19	17535470	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	4124002	17535470	41593513	160	20060											
ZNF536	9745	broad.mit.edu	37	chr19	30936464	30936464	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgaggaggatgggctgcaCgtgggcctggatgagcggcg	6	5	22	8	4	0	1	0	1	0	0	0	5	0	4	1	7	2	2	1	7	0	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:30936464C>T	uc002nsu.1	+	2	2133	c.1995C>T	c.(1993-1995)CAC>CAT	p.H665H	ZNF536_uc010edd.1_Silent_p.H665H	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	665					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					ATGGGCTGCACGTGGGCCTGG	0.692													10	46					0	0	0	0	T	30936464	T	T	30936464	2	4	107	1	0	0	0	0	0	0	0	1	18041	535	19	1		1	ZNF536	19	30936464	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	13400994	30936464	28192519	161	20061											
KIAA0355	9710	broad.mit.edu	37	chr19	34833300	34833300	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaataacacctggcccaacCgtgaccaaagtgatggagtc	14	6	10	11	1	0	2	0	2	0	0	1	4	0	3	4	2	2	0	4	2	4	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:34833300C>T	uc002nvd.3	+	10	3320	c.2461C>T	c.(2461-2463)CGT>TGT	p.R821C		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	821										ovary(1)	1	Esophageal squamous(110;0.162)					CTGGCCCAACCGTGACCAAAG	0.522													62	84					0	0	0	0	T	34833300	T	T	34833300	3	4	107	1	0	0	0	0	1	0	0	0	8209	652	23	1	2495	1	KIAA0355	19	34833300	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	3896836	34833300	24295683	162	20062											
FAM187B	148109	broad.mit.edu	37	chr19	35719283	35719283	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcatactgcaccacttggcGgccattcttgttccagcagt	7	13	8	13	1	2	0	1	0	1	0	3	0	3	0	3	2	3	3	3	2	1	6			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:35719283G>T	uc002nyk.1	-	1	346	c.301C>A	c.(301-303)CGC>AGC	p.R101S		NM_152481	NP_689694	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	101	Extracellular (Potential).					integral to membrane				ovary(2)	2						ACCACTTGGCGGCCATTCTTG	0.512													43	64					3.54561e-26	4.48709e-26	1	0	T	35719283	T	T	35719283	3	4	107	1	0	0	0	0	1	0	0	0	5541	1116	39	3	816	3	FAM187B	19	35719283	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	885983	35719283	23409700	163	20063											
ZNF382	84911	broad.mit.edu	37	chr19	37118397	37118397	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagttcttcagttgtaagtCaaacctcattgtccatcaga	12	13	7	9	0	5	1	4	0	1	1	6	2	6	1	2	0	1	3	2	0	3	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:37118397C>G	uc002oek.2	+	5	1711	c.1598C>G	c.(1597-1599)TCA>TGA	p.S533*	ZNF382_uc010efa.2_Nonsense_Mutation_p.S484*|ZNF382_uc010efb.2_Nonsense_Mutation_p.S532*|ZNF382_uc002oel.2_Nonsense_Mutation_p.S532*	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	533	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).|C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGTTGTAAGTCAAACCTCATT	0.383													16	26					0	0	0	0	G	37118397	G	G	37118397	4	3	107	1	0	0	0	0	0	1	0	0	17940	838	29	2	1608	2	ZNF382	19	37118397	Nonsense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	1399114	37118397	22010586	164	20064											
DEDD2	162989	broad.mit.edu	37	chr19	42719365	42719374	+	Frame_Shift_Del	DEL	GAAGAGCTGG	-	-																															agctaccctctgtcctctttGaagagctggaggtgccatag																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:42719365_42719374delGAAGAGCTGG	uc002osu.1	-	3	427_436	c.359_368delCCAGCTCTTC	c.(358-369)TCCAGCTCTTCAfs	p.S120fs	DEDD2_uc002osv.1_RNA|DEDD2_uc002osw.1_Frame_Shift_Del_p.S120fs|DEDD2_uc002osx.1_Frame_Shift_Del_p.P4fs|DEDD2_uc002osy.1_Frame_Shift_Del_p.S120fs	NM_133328	NP_579874	Q8WXF8	DEDD2_HUMAN	death effector domain-containing  DNA binding	120_123					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity				0		Prostate(69;0.0704)				TGTCCTCTTTGAAGAGCTGGAGGTGCCATA	0.567													---	---	---								-	42719374	-	-	42719365	7	5	107	1	0	1	0	1	0	0	0	0	4402	1294	45	0	624	0	DEDD2	19	42719365	Frame_Shift_Del	DEL	GAAGAGCTGG	TCGA-CQ-6225-01A-11D-1912-08	5600968	42719365	16409618	165	20065											
ZNF229	7772	broad.mit.edu	37	chr19	44933285	44933285	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctgatggatgtggaggtcGgagctccggccaaagctctt	7	10	14	10	2	2	1	0	1	2	0	4	4	3	4	2	5	2	2	2	5	1	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:44933285G>T	uc002oze.1	-	6	2105	c.1671C>A	c.(1669-1671)TCC>TCA	p.S557S	ZNF229_uc010ejk.1_Silent_p.S211S|ZNF229_uc010ejl.1_Silent_p.S551S	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	557	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				TGTGGAGGTCGGAGCTCCGGC	0.542													45	28					2.13384e-23	2.67028e-23	1	0	T	44933285	T	T	44933285	2	4	107	1	0	0	0	0	0	0	0	1	17849	1103	39	3		3	ZNF229	19	44933285	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	2213920	44933285	14195698	166	20066											
POLD1	5424	broad.mit.edu	37	chr19	50906794	50906794	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggaccccgacgtgatcacCggttacaacatccagaactt	12	8	8	13	3	1	2	1	1	0	1	2	4	2	3	4	2	3	1	4	2	3	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:50906794C>G	uc002psb.3	+	10	1238	c.1182C>G	c.(1180-1182)ACC>ACG	p.T394T	POLD1_uc002psc.3_Silent_p.T394T|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Silent_p.T394T	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	394					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		ACGTGATCACCGGTTACAACA	0.617								DNA_polymerases_(catalytic_subunits)					55	82					0	0	0	0	G	50906794	G	G	50906794	2	3	107	1	0	0	0	0	0	0	0	1	12245	639	23	3		3	POLD1	19	50906794	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	5973509	50906794	8222189	167	20067											
ZNF845	91664	broad.mit.edu	37	chr19	53854072	53854072	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtgtttatattttctagaTatctcttccaaatgcatgat	10	19	6	6	0	2	2	0	1	2	1	4	2	3	2	1	1	1	2	1	1	5	8			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:53854072T>A	uc010ydv.1	+	4	261	c.144T>A	c.(142-144)GAT>GAA	p.D48E	ZNF845_uc010ydw.1_Missense_Mutation_p.D48E	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	48	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTTCTAGATATCTCTTCCA	0.338													12	92					0	0	0	0	A	53854072	A	A	53854072	3	1	107	1	0	0	0	0	1	0	0	0	18258	1420	49	5	154	5	ZNF845	19	53854072	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	2947278	53854072	5274911	168	20068											
CNOT3	4849	broad.mit.edu	37	chr19	54656721	54656721	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgagacactcttcttcatCttctactatctggaggtaca	10	13	6	12	1	6	1	1	0	5	1	6	3	6	2	1	2	2	1	1	2	3	6			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr19:54656721C>G	uc002qdj.1	+	16	2333	c.2022C>G	c.(2020-2022)ATC>ATG	p.I674M	CNOT3_uc010yel.1_Missense_Mutation_p.I674M|CNOT3_uc002qdi.2_Missense_Mutation_p.S586C|CNOT3_uc002qdk.1_Missense_Mutation_p.I674M|CNOT3_uc010ere.1_RNA|CNOT3_uc002qdl.2_Missense_Mutation_p.I129M	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	674					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCTTCTTCATCTTCTACTATC	0.682													42	129					0	0	0	0	G	54656721	G	G	54656721	3	3	107	1	0	0	0	0	1	0	0	0	3635	903	32	2	2080	2	CNOT3	19	54656721	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	802649	54656721	4472262	169	20069											
RBCK1	10616	broad.mit.edu	37	chr20	408138	408138	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caactgcctgctctgcaaggTggggcctgcagggactcccc	6	7	13	15	0	1	0	0	0	1	0	2	1	2	1	4	4	5	3	4	4	2	0			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr20:408138T>C	uc002wdp.3	+	9	1902	c.1209_splice	c.e9+2	p.K403_splice	RBCK1_uc010zpm.1_Splice_Site|RBCK1_uc002wdq.3_Splice_Site_p.K361_splice|RBCK1_uc010fzy.2_Splice_Site|RBCK1_uc002wdr.3_Splice_Site_p.K233_splice	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing						interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				CTCTGCAAGGTGGGGCCTGCA	0.572													4	74					0	0	0	0	C	408138	C	C	408138	5	2	107	1	0	0	0	0	0	0	1	0	13172	1710	59	5	1264	5	RBCK1	20	408138	Splice_Site	SNP	T	TCGA-CQ-6225-01A-11D-1912-08		408138	62617382	170	20070											
SIRPB1	10326	broad.mit.edu	37	chr20	1559072	1559072	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcacacagtagtaggtgccGgcgtctgctggggtgatgtt	6	12	15	8	2	2	1	1	1	1	0	2	1	2	1	1	4	2	4	1	4	2	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr20:1559072G>C	uc010gai.2	-	2	444	c.345C>G	c.(343-345)GCC>GCG	p.A115A	SIRPB1_uc002wfk.3_Silent_p.A115A	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	115	Extracellular (Potential).|Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						AGTAGGTGCCGGCGTCTGCTG	0.532													42	196					0	0	0	0	C	1559072	C	C	1559072	2	2	107	1	0	0	0	0	0	0	0	1	14398	1103	39	3		3	SIRPB1	20	1559072	Silent	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	1150934	1559072	61466448	171	20071											
SEC23B	10483	broad.mit.edu	37	chr20	18485750	18485751	+	5'Flank	INS	-	A	A																															taatacattgcctcattcagINSaaaaaaaaaaaaaaattagg																								rs74180905		TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr20:18485750_18485751insA	uc002wqz.1	+						SEC23B_uc002wra.1_5'Flank|SEC23B_uc002wrb.1_5'Flank|SEC23B_uc010zsb.1_5'Flank|SEC23B_uc002wrc.1_5'Flank	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B						ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						GCCTCATTCAGAAAAAAAAAAA	0.371													---	---	---								A	18485751	A	A	18485750	6	5	107	0	1	1	1	0	0	0	0	0	14057	957	33	0		0	SEC23B	20	18485750	5'Flank	INS	-	TCGA-CQ-6225-01A-11D-1912-08	16926678	18485750	44539770	172	20072											
DEFB123	245936	broad.mit.edu	37	chr20	30028525	30028525	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctccttttgctgactttGactgtgctgctgctcttatc	5	17	8	11	0	1	2	0	2	1	0	3	2	2	2	1	0	5	5	1	0	2	4			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr20:30028525G>C	uc002wvy.2	+	1	115	c.24G>C	c.(22-24)TTG>TTC	p.L8F		NM_153324	NP_697019	Q8N688	DB123_HUMAN	defensin, beta 123 precursor	8					defense response to bacterium	extracellular region					0	Lung NSC(7;0.000139)|all_lung(7;0.000197)|all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TGCTGACTTTGACTGTGCTGC	0.542													147	232					0	0	0	0	C	30028525	C	C	30028525	3	2	107	1	0	0	0	0	1	0	0	0	4430	1281	45	2	26	2	DEFB123	20	30028525	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	11542775	30028525	32996995	173	20073											
XKR7	343702	broad.mit.edu	37	chr20	30584797	30584797	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtagtggcctccagctttgCgctgggcatattcttcatgt	5	14	11	11	2	2	0	1	0	1	0	3	0	3	0	2	2	2	4	2	2	2	5			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr20:30584797C>T	uc002wxe.2	+	3	1451	c.1277C>T	c.(1276-1278)GCG>GTG	p.A426V		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	426	Helical; (Potential).					integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TCCAGCTTTGCGCTGGGCATA	0.582													39	40					0	0	0	0	T	30584797	T	T	30584797	3	4	107	1	0	0	0	0	1	0	0	0	17504	768	27	1	1287	1	XKR7	20	30584797	Missense_Mutation	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	556272	30584797	32440723	174	20074											
CDK5RAP1	51654	broad.mit.edu	37	chr20	31980046	31980046	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatggtctgctcagccttcTccctagagagatcaaaggag	11	9	11	10	0	4	3	2	0	2	3	5	5	4	4	2	2	2	1	2	2	2	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr20:31980046T>C	uc010gek.2	-	5	570	c.446A>G	c.(445-447)GAG>GGG	p.E149G	CDK5RAP1_uc002wyy.2_Missense_Mutation_p.E59G|CDK5RAP1_uc002wyz.2_Missense_Mutation_p.E149G|CDK5RAP1_uc002wza.2_Missense_Mutation_p.E149G|CDK5RAP1_uc010gel.2_Missense_Mutation_p.E58G|CDK5RAP1_uc010gem.2_Missense_Mutation_p.E149G|CDK5RAP1_uc002wzc.1_Missense_Mutation_p.E149G|CDK5RAP1_uc010gen.2_Missense_Mutation_p.E149G	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	149	MTTase N-terminal.|CDK5 activation inhibition.				brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						CTCAGCCTTCTCCCTAGAGAG	0.478													4	86					0	0	0	0	C	31980046	C	C	31980046	3	2	107	1	0	0	0	0	1	0	0	0	3160	1551	54	5	1357	5	CDK5RAP1	20	31980046	Missense_Mutation	SNP	T	TCGA-CQ-6225-01A-11D-1912-08	1395249	31980046	31045474	175	20075											
RPN2	6185	broad.mit.edu	37	chr20	35852325	35852326	+	Missense_Mutation	DNP	TC	GT	GT																															gttggcatcacaaatgttgaTctttccaccgtggataagga																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr20:35852325_35852326TC>GT	uc002xgp.2	+	10	1441_1442	c.1137_1138TC>GT	c.(1135-1140)GATCTT>GAGTTT	p.379_380DL>EF	RPN2_uc002xgo.3_Missense_Mutation_p.379_380DL>EF|RPN2_uc010gfw.2_Missense_Mutation_p.222_223DL>EF|RPN2_uc002xgq.2_Missense_Mutation_p.347_348DL>EF	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	379_380	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CAAATGTTGATCTTTCCACCGT	0.49													3	66					0	0	0	0	GT	35852326	GT	GT	35852325	3	3	107	1	0	0	0	0	1	0	0	0	13673	1432	50	5	1175	5	RPN2	20	35852325	Missense_Mutation	DNP	TC	TCGA-CQ-6225-01A-11D-1912-08	3872279	35852325	27173195	176	20076											
SRC	6714	broad.mit.edu	37	chr20	36012655	36012655	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggcgggggcgctttcccCgcctcgcagacccccagcaa	5	5	13	18	4	0	1	0	0	0	1	2	1	1	1	5	3	1	4	5	3	1	1			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr20:36012655C>T	uc002xgx.2	+	4	548	c.99C>T	c.(97-99)CCC>CCT	p.P33P	SRC_uc002xgy.2_Silent_p.P33P	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	33					axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	GCGCTTTCCCCGCCTCGCAGA	0.751													11	6					0	0	0	0	T	36012655	T	T	36012655	2	4	107	1	0	0	0	0	0	0	0	1	15200	639	23	1		1	SRC	20	36012655	Silent	SNP	C	TCGA-CQ-6225-01A-11D-1912-08	160330	36012655	27012865	177	20077											
ELMO2	63916	broad.mit.edu	37	chr20	45003021	45003021	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcattttggtgagctcaatgGcactgcggccaaaggggcat	9	9	14	9	1	1	1	1	1	0	0	1	1	1	1	1	5	2	4	1	5	2	2			TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr20:45003021G>A	uc002xrt.1	-	15	1439	c.1229C>T	c.(1228-1230)GCC>GTC	p.A410V	ELMO2_uc010zxq.1_Missense_Mutation_p.A142V|ELMO2_uc002xrs.1_Missense_Mutation_p.A157V|ELMO2_uc002xru.1_Missense_Mutation_p.A410V|ELMO2_uc010zxr.1_Missense_Mutation_p.A422V|ELMO2_uc010zxs.1_Missense_Mutation_p.A227V|ELMO2_uc002xrv.1_Missense_Mutation_p.A129V|ELMO2_uc002xrw.2_Missense_Mutation_p.A227V	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	410	ELMO.				apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GAGCTCAATGGCACTGCGGCC	0.512													36	45					0	0	0	0	A	45003021	A	A	45003021	3	1	107	1	0	0	0	0	1	0	0	0	5090	1203	42	4	965	4	ELMO2	20	45003021	Missense_Mutation	SNP	G	TCGA-CQ-6225-01A-11D-1912-08	8990366	45003021	18022499	178	20078											
ITSN1	6453	broad.mit.edu	37	chr21	35208857	35208859	+	In_Frame_Del	DEL	AGG	-	-																															gaggaccctgactggtggaaAggagaagtcaatggacaagt																										TCGA-CQ-6225-01A-11D-1912-08	TCGA-CQ-6225-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	cd311590-3c69-4ff2-8fbd-cb5b0f21975e	b9418a2e-bc40-4513-ae79-d62a4f886576	g.chr21:35208857_35208859delAGG	uc002yta.1	+	29	3850_3852	c.3582_3584delAGG	c.(3580-3585)AAAGGA>AAA	p.G1195del	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_In_Frame_Del_p.G1119del|ITSN1_uc010gmg.2_In_Frame_Del_p.G1082del|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_In_Frame_Del_p.G1195del|ITSN1_uc010gmi.2_In_Frame_Del_p.G1158del|ITSN1_uc010gmj.2_In_Frame_Del_p.G1074del|ITSN1_uc002ysy.2_In_Frame_Del_p.G1190del|ITSN1_uc002ysx.2_In_Frame_Del_p.G1153del|ITSN1_uc002ytb.1_In_Frame_Del_p.G1190del|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_In_Frame_Del_p.G1087del|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_In_Frame_Del_p.G1190del|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_In_Frame_Del_p.G1058del|ITSN1_uc002yti.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1195	SH3 5.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						ACTGGTGGAAAGGAGAAGTCAAT	0.532													---	---	---								-	35208859	-	-	35208857	7	5	107	1	0	1	0	1	0	0	0	0	7965	69	3	0	3692	0	ITSN1	21	35208857	In_Frame_Del	DEL	AGG	TCGA-CQ-6225-01A-11D-1912-08		35208857	12921038	179	20079											
DVL1	1855	broad.mit.edu	37	chr1	1273937	1273937	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatggtgatcttgagccacAtgcggtcgcggatctccagt	7	10	13	11	4	2	2	0	2	2	0	4	4	2	3	2	3	2	0	2	3	0	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:1273937A>C	uc001aer.3	-	12	1276	c.1229T>G	c.(1228-1230)ATG>AGG	p.M410R	DVL1_uc002quu.2_Missense_Mutation_p.M152R|DVL1_uc009vka.2_Missense_Mutation_p.M93R|DVL1_uc001aeu.1_Missense_Mutation_p.M169R	NM_004421	NP_004412	O14640	DVL1_HUMAN	dishevelled 1	435	DEP.				canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CTTGAGCCACATGCGGTCGCG	0.672													10	41					0	0	0	0	C	1273937	C	C	1273937	3	2	108	1	0	0	0	0	1	0	0	0	4857	217	8	5	799	5	DVL1	1	1273937	Missense_Mutation	SNP	A	TCGA-CQ-6227-01A-11D-1912-08		1273937	247976684	1	20080											
DNAJC11	55735	broad.mit.edu	37	chr1	6699997	6699997	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaggtatggtttgatgatCagacggtgcatggcaaagta	11	11	14	5	1	1	4	1	3	0	1	1	4	1	4	0	4	1	5	0	4	3	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:6699997C>G	uc001aof.2	-	11	1324	c.1218G>C	c.(1216-1218)CTG>CTC	p.L406L	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Intron|DNAJC11_uc010nzu.1_Silent_p.L316L	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	406					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		GTTTGATGATCAGACGGTGCA	0.393													6	27					0	0	0	0	G	6699997	G	G	6699997	2	3	108	1	0	0	0	0	0	0	0	1	4652	813	29	2		2	DNAJC11	1	6699997	Silent	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	5426060	6699997	242550624	2	20081											
UBIAD1	29914	broad.mit.edu	37	chr1	11345928	11345928	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacgctggccatcctcatcGgccccacgttctcctacatt	6	11	6	18	3	3	0	2	0	1	0	6	0	4	0	5	2	1	2	5	2	1	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:11345928G>A	uc001asg.2	+	2	1091	c.757G>A	c.(757-759)GGC>AGC	p.G253S		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	253	Helical; (Potential).				menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		CATCCTCATCGGCCCCACGTT	0.607													13	93					0	0	0	0	A	11345928	A	A	11345928	3	1	108	1	0	0	0	0	1	0	0	0	16953	1116	39	1	763	1	UBIAD1	1	11345928	Missense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	4645931	11345928	237904693	3	20082											
HSPG2	3339	broad.mit.edu	37	chr1	22169810	22169810	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caggaatgggtcctgggctgGagggctcaattgtgaccagg	8	8	17	8	0	1	1	1	1	0	0	2	3	2	3	2	6	0	2	2	6	2	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:22169810G>A	uc001bfj.2	-	66	8778	c.8738C>T	c.(8737-8739)TCC>TTC	p.S2913F	HSPG2_uc009vqd.2_Missense_Mutation_p.S2914F	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2913	Ig-like C2-type 14.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TCCTGGGCTGGAGGGCTCAAT	0.632													10	46					0	0	0	0	A	22169810	A	A	22169810	3	1	108	1	0	0	0	0	1	0	0	0	7469	1174	41	2	4565	2	HSPG2	1	22169810	Missense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	10823882	22169810	227080811	4	20083											
CDC7	8317	broad.mit.edu	37	chr1	91978847	91978847	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgcacaaattcagattaaaCaaggaaaagacggaaaggtt	20	7	9	5	1	1	2	1	0	0	2	1	4	1	4	0	3	2	2	0	3	7	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:91978847C>A	uc001doe.2	+	7	970	c.805C>A	c.(805-807)CAA>AAA	p.Q269K	CDC7_uc001dof.2_Missense_Mutation_p.Q269K|CDC7_uc010osw.1_Missense_Mutation_p.Q241K|CDC7_uc009wdc.2_Missense_Mutation_p.Q269K|CDC7_uc009wdd.2_5'Flank	NM_003503	NP_003494	O00311	CDC7_HUMAN	cell division cycle 7	269	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	5		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		TCAGATTAAACAAGGAAAAGA	0.403													4	29					1.23904e-05	4.06243e-05	1	0	A	91978847	A	A	91978847	3	1	108	1	0	0	0	0	1	0	0	0	3099	479	17	4	827	4	CDC7	1	91978847	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	69809037	91978847	157271774	5	20084											
LAD1	3898	broad.mit.edu	37	chr1	201358343	201358343	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgagcctgggagcctcatCgtccgtggtggagctcaggt	5	9	16	11	2	2	1	2	1	0	0	4	3	3	3	3	4	3	2	3	4	0	0	rs138881525		TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:201358343C>T	uc001gwm.2	-	2	362	c.127G>A	c.(127-129)GAT>AAT	p.D43N	LAD1_uc009wzu.1_Missense_Mutation_p.D65N	NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	43						basement membrane	structural molecule activity				0						GGAGCCTCATCGTCCGTGGTG	0.642													8	34					0	0	0	0	T	201358343	T	T	201358343	3	4	108	1	0	0	0	0	1	0	0	0	8639	884	31	1	1462	1	LAD1	1	201358343	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	109379496	201358343	47892278	6	20085											
CYP1B1	1545	broad.mit.edu	37	chr2	38302533	38302533	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctgaggctggtgcccatgCtggggacagagaggagaagg	9	5	20	7	0	0	3	0	1	0	2	0	6	0	4	1	7	2	3	1	7	1	0			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr2:38302533C>T	uc002rqo.2	-	3	403	c.0_splice	c.e3-1			NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,						visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	GGTGCCCATGCTGGGGACAGA	0.667													7	40					0	0	0	0	T	38302533	T	T	38302533	5	4	108	1	0	0	0	0	0	0	1	0	4168	811	28	4	1640	4	CYP1B1	2	38302533	Splice_Site	SNP	C	TCGA-CQ-6227-01A-11D-1912-08		38302533	204896840	7	20086											
DUSP2	1844	broad.mit.edu	37	chr2	96809654	96809654	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccggcgctgcttaacgaagtCaaaggcctcgtccagccgca	9	6	11	15	5	1	0	1	0	0	0	3	1	2	0	4	2	3	3	4	2	3	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr2:96809654C>T	uc002svk.3	-	4	939	c.853G>A	c.(853-855)GAC>AAC	p.D285N		NM_004418	NP_004409	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	285	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			breast(1)	1		Ovarian(717;0.0228)				TTAACGAAGTCAAAGGCCTCG	0.622													7	21					0	0	0	0	T	96809654	T	T	96809654	3	4	108	1	0	0	0	0	1	0	0	0	4841	826	29	2	95	2	DUSP2	2	96809654	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	58507121	96809654	146389719	8	20087											
DNAH7	56171	broad.mit.edu	37	chr2	196729451	196729451	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aaacaagacaaggttcatggGttttttgcttatattgttgt	11	17	9	4	0	1	1	1	0	0	1	1	1	1	1	0	2	2	4	0	2	5	8			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr2:196729451G>C	uc002utj.3	-	41	7029	c.6928C>G	c.(6928-6930)CCC>GCC	p.P2310A		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2310	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGGTTCATGGGTTTTTTGCTT	0.433													7	104					0	0	0	0	C	196729451	C	C	196729451	3	2	108	1	0	0	0	0	1	0	0	0	4628	1261	44	4	5246	4	DNAH7	2	196729451	Missense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	99919797	196729451	46469922	9	20088											
PARP3	10039	broad.mit.edu	37	chr3	51978492	51978492	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaatttcgggaaaagacCaagaacaactgggcagagcg	18	4	12	7	2	0	4	0	0	0	4	1	5	0	5	1	2	3	1	1	2	7	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr3:51978492C>A	uc003dby.2	+	4	770	c.399C>A	c.(397-399)ACC>ACA	p.T133T	RRP9_uc003dbw.1_5'Flank|PARP3_uc003dbz.2_Silent_p.T140T	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	133					DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GGGAAAAGACCAAGAACAACT	0.517													29	107					7.01153e-11	2.46019e-10	1	0	A	51978492	A	A	51978492	2	1	108	1	0	0	0	0	0	0	0	1	11516	581	21	4		4	PARP3	3	51978492	Silent	SNP	C	TCGA-CQ-6227-01A-11D-1912-08		51978492	146043938	10	20089											
TRIM42	287015	broad.mit.edu	37	chr3	140401851	140401851	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatccaccacccatccagcCgcatcatcgagtactgccgc	9	6	7	19	3	1	0	1	0	0	0	4	1	3	0	6	0	3	3	6	0	1	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr3:140401851C>T	uc003eto.1	+	2	1080	c.889C>T	c.(889-891)CGC>TGC	p.R297C		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	297	B box-type 2.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CCCATCCAGCCGCATCATCGA	0.552													7	39					0	0	0	0	T	140401851	T	T	140401851	3	4	108	1	0	0	0	0	1	0	0	0	16584	652	23	1	895	1	TRIM42	3	140401851	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	88423359	140401851	57620579	11	20090											
BCHE	590	broad.mit.edu	37	chr3	165547361	165547361	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatctactcaaaatttcctcGgcttttgtgtaattatctct	9	18	5	9	1	3	0	1	0	2	0	6	1	4	0	1	1	1	2	1	1	5	6	rs74458984		TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr3:165547361G>A	uc003fem.3	-	2	1621	c.1461C>T	c.(1459-1461)GCC>GCT	p.A487A	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	487					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAATTTCCTCGGCTTTTGTGT	0.403													20	53					0	0	0	0	A	165547361	A	A	165547361	2	1	108	1	0	0	0	0	0	0	0	1	1360	1103	39	1		1	BCHE	3	165547361	Silent	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	25145510	165547361	32475069	12	20091											
CCKAR	886	broad.mit.edu	37	chr4	26483643	26483643	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttggccatcaggttggctgCggagctgttactccggatgc	5	11	14	11	2	1	0	1	0	0	0	2	2	2	2	2	5	4	4	2	5	1	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr4:26483643C>T	uc003gse.1	-	5	1057	c.904G>A	c.(904-906)GCA>ACA	p.A302T		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	302	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	AGGTTGGCTGCGGAGCTGTTA	0.612													25	123					0	0	0	0	T	26483643	T	T	26483643	3	4	108	1	0	0	0	0	1	0	0	0	2893	768	27	1	386	1	CCKAR	4	26483643	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08		26483643	164670633	13	20092											
ODZ3	55714	broad.mit.edu	37	chr4	183721257	183721257	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccctggacgaggagaaggCgcgcatcctggagcaggcgc	9	3	17	12	4	0	1	0	0	0	1	1	6	1	3	2	5	1	2	2	5	1	0			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr4:183721257C>T	uc003ivd.1	+	27	7890	c.7853C>T	c.(7852-7854)GCG>GTG	p.A2618V		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2618	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GAGGAGAAGGCGCGCATCCTG	0.751													4	11					0	0	0	0	T	183721257	T	T	183721257	3	4	108	1	0	0	0	0	1	0	0	0	10890	768	27	1	7959	1	ODZ3	4	183721257	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	157237614	183721257	7433019	14	20093											
HIST1H2AM	8336	broad.mit.edu	37	chr6	27860847	27860847	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcggtgcactcgtcctacAggaaattggagcccagctct	9	8	12	12	2	1	0	0	0	1	0	3	2	2	2	2	4	4	2	2	4	2	2			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr6:27860847A>G	uc003nkb.1	-	1	117	c.81T>C	c.(79-81)CCT>CCC	p.P27P	HIST1H3J_uc003nka.2_5'Flank|HIST1H2BO_uc003nkc.1_5'Flank	NM_003514	NP_003505	P0C0S8	H2A1_HUMAN	histone cluster 1, H2am	27					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			ovary(2)	2						CTCGTCCTACAGGAAATTGGA	0.647													12	54					0	0	0	0	G	27860847	G	G	27860847	2	3	108	1	0	0	0	0	0	0	0	1	7178	175	7	5		5	HIST1H2AM	6	27860847	Silent	SNP	A	TCGA-CQ-6227-01A-11D-1912-08		27860847	143254220	15	20094											
IP6K3	117283	broad.mit.edu	37	chr6	33690810	33690810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taatgacagagaggagggccCggagctggtgcaggatgggc	10	5	19	7	1	0	2	0	1	0	1	0	6	0	5	1	6	2	2	1	6	1	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr6:33690810C>T	uc010jvf.2	-	7	1456	c.920G>A	c.(919-921)CGG>CAG	p.R307Q	IP6K3_uc003ofb.2_Missense_Mutation_p.R307Q	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	307					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						GAGGAGGGCCCGGAGCTGGTG	0.552													4	38					0	0	0	0	T	33690810	T	T	33690810	3	4	108	1	0	0	0	0	1	0	0	0	7829	652	23	1	316	1	IP6K3	6	33690810	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	5829963	33690810	137424257	16	20095											
AQP1	358	broad.mit.edu	37	chr7	30951738	30951738	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagtgtgggccacatcagcGgcgcccacctcaacccggct	8	5	12	16	3	2	1	2	0	0	1	2	1	2	1	4	3	2	1	4	3	1	0			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr7:30951738G>A	uc003tbv.1	+	1	271	c.214G>A	c.(214-216)GGC>AGC	p.G72S	AQP1_uc011kac.1_Missense_Mutation_p.G132S	NM_198098	NP_932766	P29972	AQP1_HUMAN	aquaporin 1	72					ammonium transport|cell volume homeostasis|cellular hyperosmotic response|cellular response to cAMP|cellular response to copper ion|cellular response to dexamethasone stimulus|cellular response to hydrogen peroxide|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to mercury ion|cellular response to nitric oxide|cellular response to retinoic acid|cellular response to salt stress|cellular response to UV|cerebrospinal fluid secretion|cGMP biosynthetic process|establishment or maintenance of actin cytoskeleton polarity|lateral ventricle development|maintenance of symbiont-containing vacuole via substance secreted by host|negative regulation of apoptosis|odontogenesis|pancreatic juice secretion|positive regulation of angiogenesis|positive regulation of fibroblast proliferation|positive regulation of saliva secretion|renal water transport|response to drug|transepithelial water transport	apical plasma membrane|basal plasma membrane|brush border membrane|cytoplasm|integral to plasma membrane|nuclear membrane|sarcolemma|symbiont-containing vacuole	ammonia transmembrane transporter activity|carbon dioxide transmembrane transporter activity|glycerol transmembrane transporter activity|intracellular cGMP activated cation channel activity|nitric oxide transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|protein binding|water channel activity				0		Melanoma(862;0.16)			Acetazolamide(DB00819)	CCACATCAGCGGCGCCCACCT	0.657													6	50					0	0	0	0	A	30951738	A	A	30951738	3	1	108	1	0	0	0	0	1	0	0	0	821	1116	39	1	216	1	AQP1	7	30951738	Missense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08		30951738	128186925	17	20096											
TRIM50	135892	broad.mit.edu	37	chr7	72730600	72730600	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagagccttttccacacggTcagcttgatgtcagcctggt	8	11	11	11	1	2	2	2	1	0	1	3	3	3	2	3	2	3	1	3	2	1	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr7:72730600T>C	uc010lbd.1	-	6	963	c.838A>G	c.(838-840)ACC>GCC	p.T280A	FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Missense_Mutation_p.T280A|TRIM50_uc003txz.1_Missense_Mutation_p.T279A	NM_178125	NP_835226	Q86XT4	TRI50_HUMAN	tripartite motif protein 50A	280	B30.2/SPRY.					cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1						TTCCACACGGTCAGCTTGATG	0.617													8	42					0	0	0	0	C	72730600	C	C	72730600	3	2	108	1	0	0	0	0	1	0	0	0	16593	1667	58	5	633	5	TRIM50	7	72730600	Missense_Mutation	SNP	T	TCGA-CQ-6227-01A-11D-1912-08	41778862	72730600	86408063	18	20097											
SLC13A4	26266	broad.mit.edu	37	chr7	135390963	135390963	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgcagcacggcctccaCgatgggcatcaccatggcgg	7	6	12	16	3	1	0	1	0	0	0	3	1	3	0	4	4	2	3	4	4	0	0			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr7:135390963C>T	uc003vta.2	-	4	1140	c.451G>A	c.(451-453)GTG>ATG	p.V151M	SLC13A4_uc003vtb.2_Missense_Mutation_p.V151M	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	151						integral to plasma membrane	sodium:sulfate symporter activity				0						ACGGCCTCCACGATGGGCATC	0.612													10	59					0	0	0	0	T	135390963	T	T	135390963	3	4	108	1	0	0	0	0	1	0	0	0	14459	536	19	1	1481	1	SLC13A4	7	135390963	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	62660363	135390963	23747700	19	20098											
KIAA0196	9897	broad.mit.edu	37	chr8	126067886	126067886	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagatgccttcagtaaaaaTggaaatagcatgagtaagct	17	10	9	5	0	1	2	1	1	0	1	1	3	1	3	1	1	3	4	1	1	7	5			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr8:126067886T>C	uc003yrt.2	-	17	2373	c.2044A>G	c.(2044-2046)ATT>GTT	p.I682V	KIAA0196_uc011lir.1_Missense_Mutation_p.I534V|KIAA0196_uc003yru.1_Missense_Mutation_p.I256V	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	682					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TCAGTAAAAATGGAAATAGCA	0.383													29	113					0	0	0	0	C	126067886	C	C	126067886	3	2	108	1	0	0	0	0	1	0	0	0	8200	1464	51	5	1487	5	KIAA0196	8	126067886	Missense_Mutation	SNP	T	TCGA-CQ-6227-01A-11D-1912-08		126067886	20296136	20	20099											
TEK	7010	broad.mit.edu	37	chr9	27220064	27220064	+	Frame_Shift_Del	DEL	G	-	-																															caggaggcacaccctactgcGggatgacttgtgcagaactc																										TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr9:27220064delG	uc003zqi.3	+	21	3563	c.3121delG	c.(3121-3123)GGGfs	p.G1041fs	TEK_uc011lno.1_Frame_Shift_Del_p.G998fs|TEK_uc011lnp.1_Frame_Shift_Del_p.G893fs	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	1041	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ACCCTACTGCGGGATGACTTG	0.527													---	---	---								-	27220064	-	-	27220064	7	5	108	1	0	1	0	1	0	0	0	0	15817	1116	39	0	3203	0	TEK	9	27220064	Frame_Shift_Del	DEL	G	TCGA-CQ-6227-01A-11D-1912-08		27220064	113993367	21	20100											
ZNF618	114991	broad.mit.edu	37	chr9	116750680	116750680	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccgaggcctcgctgagtgccGagcaaggaacgatgacggag	10	4	16	11	5	0	2	0	2	0	0	1	7	0	4	3	3	3	2	3	3	2	0			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr9:116750680G>C	uc004bid.2	+	3	256	c.157G>C	c.(157-159)GAG>CAG	p.E53Q	ZNF618_uc004bib.1_Missense_Mutation_p.E53Q|ZNF618_uc004bic.2_Missense_Mutation_p.E53Q|ZNF618_uc011lxi.1_Missense_Mutation_p.E53Q|ZNF618_uc011lxj.1_Missense_Mutation_p.E53Q	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCTGAGTGCCGAGCAAGGAAC	0.612													6	22					0	0	0	0	C	116750680	C	C	116750680	3	2	108	1	0	0	0	0	1	0	0	0	18109	1059	37	3	167	3	ZNF618	9	116750680	Missense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	89530616	116750680	24462751	22	20101											
CEP110	11064	broad.mit.edu	37	chr9	123860779	123860779	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccattttccacctccgttCattggaaagtttggaaggtc	9	14	8	10	1	1	0	1	0	0	0	4	2	3	2	4	3	1	2	4	3	3	6			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr9:123860779C>T	uc004bkx.1	+	5	768	c.737C>T	c.(736-738)TCA>TTA	p.S246L	CEP110_uc004bkw.2_Missense_Mutation_p.S246L	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	246	LRRCT.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						CACCTCCGTTCATTGGAAAGT	0.373													8	27					0	0	0	0	T	123860779	T	T	123860779	3	4	108	1	0	0	0	0	1	0	0	0	3260	838	29	2	755	2	CEP110	9	123860779	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	7110099	123860779	17352652	23	20102											
FGF19	9965	broad.mit.edu	37	chr11	69518109	69518109	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatggccacggtccgcagagCgactgccttgatctccagca	8	7	12	14	3	1	2	0	1	1	1	3	4	2	2	4	2	3	2	4	2	0	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr11:69518109C>T	uc001opf.2	-	2	719	c.256G>A	c.(256-258)GCT>ACT	p.A86T		NM_005117	NP_005108	O95750	FGF19_HUMAN	fibroblast growth factor 19 precursor	86					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of bile acid biosynthetic process|nervous system development|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import|positive regulation of JNK cascade	extracellular region	fibroblast growth factor receptor binding|growth factor activity			skin(1)	1	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;3.05e-56)|all cancers(3;2.69e-50)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			GTCCGCAGAGCGACTGCCTTG	0.677													5	19					0	0	0	0	T	69518109	T	T	69518109	3	4	108	1	0	0	0	0	1	0	0	0	5879	768	27	1	402	1	FGF19	11	69518109	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08		69518109	65488407	24	20103											
CLPB	81570	broad.mit.edu	37	chr11	72145270	72145270	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtccccaagtggcagccgcGaggcatttggtatcgaagcg	8	7	14	12	5	0	0	0	0	0	0	2	2	1	0	3	3	2	3	3	3	3	2			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr11:72145270G>T	uc001osj.2	-	1	299	c.249C>A	c.(247-249)CTC>CTA	p.L83L	CLPB_uc010rqx.1_Missense_Mutation_p.R3S|CLPB_uc010rqy.1_Silent_p.L83L|CLPB_uc001osk.2_Silent_p.L83L|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_5'UTR	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	83					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						TGGCAGCCGCGAGGCATTTGG	0.692											OREG0021194	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	45					1.10923e-09	3.76011e-09	1	0	T	72145270	T	T	72145270	2	4	108	1	0	0	0	0	0	0	0	1	3566	1045	37	3		3	CLPB	11	72145270	Silent	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	2627161	72145270	62861246	25	20104											
SLCO2B1	11309	broad.mit.edu	37	chr11	74904300	74904300	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagaccctacgccacccCatcttcctgctggtggtcct	5	10	8	18	1	1	1	0	0	1	1	3	1	3	1	6	2	3	2	6	2	1	2			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr11:74904300C>T	uc001owb.2	+	9	1500	c.1113C>T	c.(1111-1113)CCC>CCT	p.P371P	SLCO2B1_uc010rrq.1_Silent_p.P116P|SLCO2B1_uc010rrr.1_Silent_p.P227P|SLCO2B1_uc010rrs.1_Silent_p.P255P|SLCO2B1_uc001owc.2_Silent_p.P144P|SLCO2B1_uc001owd.2_Silent_p.P349P	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	371	Helical; Name=7; (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	TACGCCACCCCATCTTCCTGC	0.627													19	80					0	0	0	0	T	74904300	T	T	74904300	2	4	108	1	0	0	0	0	0	0	0	1	14791	581	21	4		4	SLCO2B1	11	74904300	Silent	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	2759030	74904300	60102216	26	20105											
GPRC5A	9052	broad.mit.edu	37	chr12	13061574	13061574	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggaggaagcccctttccCtgttggtgattctgggtctg	4	12	16	9	0	2	1	0	1	2	0	3	3	3	3	3	5	1	1	3	5	1	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr12:13061574C>T	uc001rba.2	+	2	1041	c.391C>T	c.(391-393)CTG>TTG	p.L131L	GPRC5A_uc001raz.2_Silent_p.L131L	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	131	Helical; Name=4; (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	GCCCCTTTCCCTGTTGGTGAT	0.522													48	183					0	0	0	0	T	13061574	T	T	13061574	2	4	108	1	0	0	0	0	0	0	0	1	6763	680	24	4		4	GPRC5A	12	13061574	Silent	SNP	C	TCGA-CQ-6227-01A-11D-1912-08		13061574	120790321	27	20106											
OR10AD1	121275	broad.mit.edu	37	chr12	48596393	48596393	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacctgaggaggaggctttgCtgaggatggtggccaggatg	8	8	19	6	0	0	2	0	2	0	0	0	7	0	6	2	7	1	2	2	7	0	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr12:48596393C>T	uc001rrl.1	-	1	683	c.683G>A	c.(682-684)AGC>AAC	p.S228N		NM_001004134	NP_001004134	Q8NGE0	O10AD_HUMAN	olfactory receptor, family 10, subfamily AD,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGAGGCTTTGCTGAGGATGGT	0.507													7	41					0	0	0	0	T	48596393	T	T	48596393	3	4	108	1	0	0	0	0	1	0	0	0	10950	797	28	4	274	4	OR10AD1	12	48596393	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	35534819	48596393	85255502	28	20107											
HOXC6	3223	broad.mit.edu	37	chr12	54422634	54422634	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttagttctgagcagggcaGgactgcgccccaggaccaga	9	8	13	11	1	1	2	0	1	1	1	1	4	1	4	3	3	2	3	3	3	1	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr12:54422634G>T	uc001sev.2	+	1	441	c.329G>T	c.(328-330)AGG>ATG	p.R110M	HOXC6_uc001ses.2_Missense_Mutation_p.R28M|HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron	NM_004503	NP_004494	P09630	HXC6_HUMAN	homeobox C6 isoform 1	110					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|upper_aerodigestive_tract(1)	3						GAGCAGGGCAGGACTGCGCCC	0.468													10	110					2.74318e-10	9.45924e-10	1	0	T	54422634	T	T	54422634	3	4	108	1	0	0	0	0	1	0	0	0	7354	1000	35	4	331	4	HOXC6	12	54422634	Missense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	5826241	54422634	79429261	29	20108											
ACIN1	22985	broad.mit.edu	37	chr14	23532678	23532678	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgctctgcaggtgggggcaAggccacctctactgacacct	8	8	12	13	0	2	1	0	1	2	0	2	1	2	1	3	4	3	3	3	4	2	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr14:23532678A>T	uc001wit.3	-	13	3206	c.2878T>A	c.(2878-2880)TTG>ATG	p.L960M	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.L202M|ACIN1_uc001wiq.3_Missense_Mutation_p.L202M|ACIN1_uc001wir.3_Missense_Mutation_p.L233M|ACIN1_uc001wis.3_Missense_Mutation_p.L641M|ACIN1_uc010akg.2_Missense_Mutation_p.L947M	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	960					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGTGGGGGCAAGGCCACCTCT	0.517													18	44					0	0	0	0	T	23532678	T	T	23532678	3	4	108	1	0	0	0	0	1	0	0	0	142	69	3	5	1175	5	ACIN1	14	23532678	Missense_Mutation	SNP	A	TCGA-CQ-6227-01A-11D-1912-08		23532678	83816862	30	20109											
SLC7A8	23428	broad.mit.edu	37	chr14	23609754	23609754	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taggcaaaggagccctgaagGaaagccagtgcgacgaggcc	13	3	15	10	2	0	1	0	1	0	0	0	5	0	3	3	4	3	1	3	4	4	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr14:23609754G>A	uc001wiz.2	-	5	1440	c.714C>T	c.(712-714)TTC>TTT	p.F238F	SLC7A8_uc001wix.2_Silent_p.F35F|SLC7A8_uc010tnk.1_Intron|SLC7A8_uc010tnl.1_Silent_p.F133F|SLC7A8_uc001wiy.2_RNA|SLC7A8_uc010akj.2_Silent_p.F238F	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	238	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	AGCCCTGAAGGAAAGCCAGTG	0.502													13	164					0	0	0	0	A	23609754	A	A	23609754	2	1	108	1	0	0	0	0	0	0	0	1	14768	1165	41	2		2	SLC7A8	14	23609754	Silent	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	77076	23609754	83739786	31	20110											
KCNH5	27133	broad.mit.edu	37	chr14	63468148	63468148	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgttcatttcttattggtgCaatttgcatataaaaccaaa	14	16	5	6	0	2	0	1	0	1	0	2	0	2	0	1	1	3	3	1	1	6	7			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr14:63468148C>T	uc001xfx.2	-	4	385	c.334G>A	c.(334-336)GCA>ACA	p.A112T	KCNH5_uc001xfy.2_Missense_Mutation_p.A112T|KCNH5_uc001xfz.1_Missense_Mutation_p.A54T|KCNH5_uc001xga.2_Missense_Mutation_p.A54T	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	112	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CTTATTGGTGCAATTTGCATA	0.423													4	20					0	0	0	0	T	63468148	T	T	63468148	3	4	108	1	0	0	0	0	1	0	0	0	8074	710	25	4	2698	4	KCNH5	14	63468148	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	39858394	63468148	43881392	32	20111											
EXD2	55218	broad.mit.edu	37	chr14	69701570	69701570	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccagggtgtggtcgacatcCcatttcgaagcaaaggaatg	11	8	13	9	2	0	0	0	0	0	0	3	3	1	1	2	3	1	1	2	3	3	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr14:69701570C>G	uc001xkt.2	+	7	1155	c.496C>G	c.(496-498)CCA>GCA	p.P166A	EXD2_uc001xku.2_Missense_Mutation_p.P36A|EXD2_uc001xkv.2_Missense_Mutation_p.P291A|EXD2_uc001xkw.2_Missense_Mutation_p.P166A|EXD2_uc010aqt.2_Missense_Mutation_p.P291A|EXD2_uc010tte.1_Missense_Mutation_p.P291A|EXD2_uc001xky.2_Missense_Mutation_p.P166A	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	166					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						GGTCGACATCCCATTTCGAAG	0.443													9	45					0	0	0	0	G	69701570	G	G	69701570	3	3	108	1	0	0	0	0	1	0	0	0	5322	623	22	4	506	4	EXD2	14	69701570	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	6233422	69701570	37647970	33	20112											
DMXL2	23312	broad.mit.edu	37	chr15	51741321	51741321	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gactccagccccaatgtttcGaaatatggactgcttagcat	11	11	8	11	1	0	0	0	0	0	0	2	3	1	1	3	1	3	3	3	1	4	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr15:51741321G>A	uc002abf.2	-	43	9196	c.8971C>T	c.(8971-8973)CGA>TGA	p.R2991*	DMXL2_uc002abd.2_Nonsense_Mutation_p.R1083*|DMXL2_uc010ufy.1_Nonsense_Mutation_p.R2992*|DMXL2_uc010bfa.2_Nonsense_Mutation_p.R2355*|DMXL2_uc002abc.2_RNA	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2991						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CCAATGTTTCGAAATATGGAC	0.438													6	43					0	0	0	0	A	51741321	A	A	51741321	4	1	108	1	0	0	0	0	0	1	0	0	4617	1066	37	1	143	1	DMXL2	15	51741321	Nonsense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08		51741321	50790071	34	20113											
SLC28A1	9154	broad.mit.edu	37	chr15	85488064	85488064	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctcagcagcagtagctttGagatttaccagtgctgccgt	8	11	10	12	1	1	1	1	1	0	1	1	2	1	1	3	0	6	5	3	0	2	4			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr15:85488064G>C	uc002blg.2	+	18	2042	c.1840G>C	c.(1840-1842)GAG>CAG	p.E614Q	SLC28A1_uc010bnb.2_Missense_Mutation_p.E614Q|SLC28A1_uc010upe.1_Missense_Mutation_p.E448Q|SLC28A1_uc010upf.1_Missense_Mutation_p.E614Q|SLC28A1_uc010upg.1_Intron	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	614					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGTAGCTTTGAGATTTACCA	0.592													14	48					0	0	0	0	C	85488064	C	C	85488064	3	2	108	1	0	0	0	0	1	0	0	0	14595	1291	45	2	1973	2	SLC28A1	15	85488064	Missense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	33746743	85488064	17043328	35	20114											
MYLK3	91807	broad.mit.edu	37	chr16	46766444	46766444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggggcttggaggcagcGcccggtcccaggtgggccct	4	5	17	15	2	0	0	0	0	0	0	1	1	1	1	4	7	1	2	4	7	0	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr16:46766444G>A	uc002eei.3	-	4	1254	c.1138C>T	c.(1138-1140)CGC>TGC	p.R380C	MYLK3_uc010vge.1_Missense_Mutation_p.R39C|MYLK3_uc002eej.1_Missense_Mutation_p.R39C	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	380					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TGGAGGCAGCGCCCGGTCCCA	0.687													7	25					0	0	0	0	A	46766444	A	A	46766444	3	1	108	1	0	0	0	0	1	0	0	0	10111	1087	38	1	1361	1	MYLK3	16	46766444	Missense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08		46766444	43588309	36	20115											
KIAA1609	57707	broad.mit.edu	37	chr16	84520478	84520478	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatgctctcaaaacccctGccctggtccacttgacgctc	8	9	8	16	1	1	1	1	1	1	0	4	2	2	2	4	2	3	2	4	2	2	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr16:84520478G>T	uc002fib.2	-	5	824	c.717C>A	c.(715-717)GGC>GGA	p.G239G	KIAA1609_uc010vod.1_Silent_p.G212G|KIAA1609_uc002fic.2_RNA	NM_020947	NP_065998	Q6P9B6	K1609_HUMAN	hypothetical protein LOC57707	239							protein binding			ovary(2)	2						CAAAACCCCTGCCCTGGTCCA	0.567													9	32					0.000274275	0.000884758	1	0	T	84520478	T	T	84520478	2	4	108	1	0	0	0	0	0	0	0	1	8286	1306	46	4		4	KIAA1609	16	84520478	Silent	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	37754034	84520478	5834275	37	20116											
KIAA0100	9703	broad.mit.edu	37	chr17	26968962	26968962	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctggcacagcagttggctCtggaagaggccctcatgcag	8	7	13	13	0	2	1	1	0	1	1	2	2	2	2	2	4	2	5	2	4	1	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr17:26968962C>G	uc002hbu.2	-	7	810	c.711G>C	c.(709-711)CAG>CAC	p.Q237H	KIAA0100_uc002hbv.2_Missense_Mutation_p.Q237H|KIAA0100_uc010crr.1_Missense_Mutation_p.Q94H	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	237						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GCAGTTGGCTCTGGAAGAGGC	0.547													15	63					0	0	0	0	G	26968962	G	G	26968962	3	3	108	1	0	0	0	0	1	0	0	0	8193	912	32	2	6128	2	KIAA0100	17	26968962	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08		26968962	54226248	38	20117											
EVPL	2125	broad.mit.edu	37	chr17	74006565	74006565	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactctctccctgcttgggcAgggctctcggagccctgctt	3	11	12	15	1	2	0	0	0	2	0	5	2	3	1	2	3	3	4	2	3	0	2			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr17:74006565A>G	uc002jqi.2	-	22	2949	c.2721T>C	c.(2719-2721)CCT>CCC	p.P907P	EVPL_uc010wss.1_Silent_p.P929P|EVPL_uc010wst.1_Silent_p.P377P	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	907	Central fibrous rod domain.|Potential.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						CTGCTTGGGCAGGGCTCTCGG	0.642													10	34					0	0	0	0	G	74006565	G	G	74006565	2	3	108	1	0	0	0	0	0	0	0	1	5316	175	7	5		5	EVPL	17	74006565	Silent	SNP	A	TCGA-CQ-6227-01A-11D-1912-08	47037603	74006565	7188645	39	20118											
B3GNT3	10331	broad.mit.edu	37	chr19	17918902	17918902	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccgccactttcccctgctgCaggacgtgcccccctctaag	5	8	9	19	2	1	0	0	0	1	0	2	1	2	1	7	1	3	2	7	1	1	2			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr19:17918902C>T	uc002nhk.1	+	2	371	c.286C>T	c.(286-288)CAG>TAG	p.Q96*	B3GNT3_uc002nhl.1_Nonsense_Mutation_p.Q96*|B3GNT3_uc010ebd.1_Nonsense_Mutation_p.Q96*|B3GNT3_uc010ebe.1_Nonsense_Mutation_p.Q96*	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	96	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						TCCCCTGCTGCAGGACGTGCC	0.637													4	27					0	0	0	0	T	17918902	T	T	17918902	4	4	108	1	0	0	0	0	0	1	0	0	1260	711	25	4	288	4	B3GNT3	19	17918902	Nonsense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08		17918902	41210081	40	20119											
ZNF568	374900	broad.mit.edu	37	chr19	37440779	37440779	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgacctcattagacatgagCgaattcatgctggagagaaa	14	10	10	7	1	2	4	2	2	0	2	2	7	2	5	1	1	2	1	1	1	3	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr19:37440779C>T	uc002ofc.2	+	7	1239	c.724C>T	c.(724-726)CGA>TGA	p.R242*	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Nonsense_Mutation_p.R166*|ZNF568_uc010efe.2_Nonsense_Mutation_p.R166*|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	242	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TAGACATGAGCGAATTCATGC	0.378													7	46					0	0	0	0	T	37440779	T	T	37440779	4	4	108	1	0	0	0	0	0	1	0	0	18066	760	27	1	742	1	ZNF568	19	37440779	Nonsense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	19521877	37440779	21688204	41	20120											
TBC1D17	79735	broad.mit.edu	37	chr19	50385367	50385367	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctctctccaactccttccaCcacctgcagctctttgacca	7	11	4	19	0	2	1	0	1	2	0	6	1	5	1	6	0	3	3	6	0	1	2			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr19:50385367C>T	uc002pqo.2	+	6	749	c.597C>T	c.(595-597)CAC>CAT	p.H199H	TBC1D17_uc010enn.1_RNA|TBC1D17_uc010ybg.1_Silent_p.H166H|TBC1D17_uc002pqp.2_5'UTR|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_5'UTR|TBC1D17_uc002pqs.2_5'Flank	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	199						intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		ACTCCTTCCACCACCTGCAGC	0.647													12	260					0	0	0	0	T	50385367	T	T	50385367	2	4	108	1	0	0	0	0	0	0	0	1	15672	506	18	4		4	TBC1D17	19	50385367	Silent	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	12944588	50385367	8743616	42	20121											
SHANK1	50944	broad.mit.edu	37	chr19	51200915	51200915	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctctttgccttgtcactgCggctttctgcagggtgacaa	5	14	11	11	1	3	1	1	1	2	0	4	1	3	1	1	2	3	2	1	2	1	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr19:51200915C>T	uc002psx.1	-	13	1887	c.1868G>A	c.(1867-1869)CGC>CAC	p.R623H		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	623					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CTTGTCACTGCGGCTTTCTGC	0.547													11	82					0	0	0	0	T	51200915	T	T	51200915	3	4	108	1	0	0	0	0	1	0	0	0	14329	768	27	1	4661	1	SHANK1	19	51200915	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	815548	51200915	7928068	43	20122											
ZNF17	7565	broad.mit.edu	37	chr19	57931031	57931031	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catggagccaaggatgaggaGgcaccttccaagcaatgtgt	12	7	13	9	0	0	1	0	1	0	0	1	4	1	4	3	4	2	2	3	4	3	1			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr19:57931031G>A	uc002qoo.1	+	3	402	c.171G>A	c.(169-171)GAG>GAA	p.E57E	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Silent_p.E59E	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	57	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		AGGATGAGGAGGCACCTTCCA	0.493													16	65					0	0	0	0	A	57931031	A	A	57931031	2	1	108	1	0	0	0	0	0	0	0	1	17810	991	35	4		4	ZNF17	19	57931031	Silent	SNP	G	TCGA-CQ-6227-01A-11D-1912-08	6730116	57931031	1197952	44	20123											
WFDC8	90199	broad.mit.edu	37	chr20	44180733	44180733	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccaccaatgggcactcctCatcctgcaggcacttgggtt	7	11	9	14	0	1	0	1	0	0	0	4	0	4	0	4	3	1	4	4	3	1	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr20:44180733C>G	uc002xow.2	-	6	737	c.658G>C	c.(658-660)GAG>CAG	p.E220Q	WFDC8_uc002xox.2_Missense_Mutation_p.E220Q	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	220	WAP 3.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GGGCACTCCTCATCCTGCAGG	0.423													13	89					0	0	0	0	G	44180733	G	G	44180733	3	3	108	1	0	0	0	0	1	0	0	0	17424	835	29	2	71	2	WFDC8	20	44180733	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08		44180733	18844787	45	20124											
GRIK1	2897	broad.mit.edu	37	chr21	30934006	30934006	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccccgatctgagtgaggttGcagtttctctgcgtcacata	7	12	10	12	2	3	2	1	2	2	0	4	3	3	2	2	1	2	3	2	1	1	3			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr21:30934006G>T	uc002yno.1	-	15	2759	c.2295C>A	c.(2293-2295)TGC>TGA	p.C765*	GRIK1_uc002ynn.2_Nonsense_Mutation_p.C750*|GRIK1_uc011acs.1_Nonsense_Mutation_p.C765*|GRIK1_uc011act.1_Nonsense_Mutation_p.C626*	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	765	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GAGTGAGGTTGCAGTTTCTCT	0.507													11	58					7.03913e-09	2.34638e-08	1	0	T	30934006	T	T	30934006	4	4	108	1	0	0	0	0	0	1	0	0	6812	1311	46	4	633	4	GRIK1	21	30934006	Nonsense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08		30934006	17195889	46	20125											
MX2	4600	broad.mit.edu	37	chr21	42754440	42754440	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaccatcattgaccttccCggcatcaccagggtggctgt	7	10	10	14	1	2	2	2	2	0	0	3	2	3	2	4	3	0	2	4	3	0	2	rs145539486	byFrequency	TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr21:42754440C>T	uc002yzf.1	+	5	785	c.681C>T	c.(679-681)CCC>CCT	p.P227P	MX2_uc011aer.1_RNA	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	227	GTP (Potential).				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				TTGACCTTCCCGGCATCACCA	0.602													9	78					0	0	0	0	T	42754440	T	T	42754440	2	4	108	1	0	0	0	0	0	0	0	1	10051	639	23	1		1	MX2	21	42754440	Silent	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	11820434	42754440	5375455	47	20126											
CABP7	164633	broad.mit.edu	37	chr22	30125152	30125152	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acatcatcatgacggaggagGagagccacctgggcacagcc	12	4	13	12	1	2	2	2	1	0	1	2	5	2	4	3	4	2	1	3	4	0	0			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr22:30125152G>A	uc003agl.2	+	4	545	c.475G>A	c.(475-477)GAG>AAG	p.E159K		NM_182527	NP_872333	Q86V35	CABP7_HUMAN	calcium binding protein 7	159	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding				0			OV - Ovarian serous cystadenocarcinoma(5;0.00442)|Epithelial(10;0.215)|all cancers(5;0.233)			GACGGAGGAGGAGAGCCACCT	0.617													6	21					0	0	0	0	A	30125152	A	A	30125152	3	1	108	1	0	0	0	0	1	0	0	0	2547	1175	41	2	489	2	CABP7	22	30125152	Missense_Mutation	SNP	G	TCGA-CQ-6227-01A-11D-1912-08		30125152	21179414	48	20127											
MICALL1	85377	broad.mit.edu	37	chr22	38328571	38328571	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttgggcaggtccaggctgaCcagtacatccctgaggagga	9	7	15	10	0	0	2	0	2	0	0	2	4	2	4	3	5	1	4	3	5	1	2			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr22:38328571C>G	uc003aui.2	+	11	2112	c.2028C>G	c.(2026-2028)GAC>GAG	p.D676E		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	676						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					TCCAGGCTGACCAGTACATCC	0.632													14	70					0	0	0	0	G	38328571	G	G	38328571	3	3	108	1	0	0	0	0	1	0	0	0	9626	506	18	4	2070	4	MICALL1	22	38328571	Missense_Mutation	SNP	C	TCGA-CQ-6227-01A-11D-1912-08	8203419	38328571	12975995	49	20128											
AR	367	broad.mit.edu	37	chrX	66765161	66765161	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccagtttgctgctgctgcAgcagcagcagcagcagcagc	8	6	13	14	1	0	0	0	0	0	0	0	0	0	0	1	0	11	11	1	0	0	1	rs5902610		TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chrX:66765161A>T	uc004dwu.1	+	1	1288	c.173A>T	c.(172-174)CAG>CTG	p.Q58L	AR_uc011mpd.1_Missense_Mutation_p.Q58L|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.Q58L	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	58	Modulating.|Poly-Gln.|Gln-rich.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CTGCTGCTgcagcagcagcag	0.328									Androgen_Insensitivity_Syndrome				3	11					0	0	0	0	T	66765161	T	T	66765161	3	4	108	1	0	0	0	0	1	0	0	0	836	188	7	5	175	5	AR	23	66765161	Missense_Mutation	SNP	A	TCGA-CQ-6227-01A-11D-1912-08		66765161	88505399	50	20129											
UBR4	23352	broad.mit.edu	37	chr1	19524242	19524242	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaactgcatcttggaacCgattgatatagcgtaggaaa	15	10	9	7	2	1	1	0	1	1	0	1	4	1	3	1	2	4	2	1	2	7	6			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:19524242C>T	uc001bbi.2	-	7	819	c.815G>A	c.(814-816)CGG>CAG	p.R272Q		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	272					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ATCTTGGAACCGATTGATATA	0.443													47	22					0	0	0	0	T	19524242	T	T	19524242	3	4	109	1	0	0	0	0	1	0	0	0	16972	652	23	1	15136	1	UBR4	1	19524242	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08		19524242	229726379	1	20130											
AKR7A2	8574	broad.mit.edu	37	chr1	19633547	19633547	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagaagcggcccacaggcTgtttcccgtccttgtcctca	8	9	9	15	2	1	1	1	0	0	1	4	1	4	1	4	2	1	2	4	2	2	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:19633547T>C	uc001bbw.2	-	5	759	c.737A>G	c.(736-738)CAG>CGG	p.Q246R	AKR7A2_uc001bbx.2_Missense_Mutation_p.Q211R	NM_003689	NP_003680	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2	246					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCACAGGCTGTTTCCCGTC	0.622													3	70					0	0	0	0	C	19633547	C	C	19633547	3	2	109	1	0	0	0	0	1	0	0	0	475	1580	55	5	354	5	AKR7A2	1	19633547	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	109305	19633547	229617074	2	20131											
INADL	10207	broad.mit.edu	37	chr1	62234980	62234980	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaaattgaatatatagataTagaacggccttcaactggag	16	10	9	6	1	1	3	1	1	0	2	1	4	1	4	1	2	2	1	1	2	9	7			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:62234980T>C	uc001dab.2	+	5	524	c.410T>C	c.(409-411)ATA>ACA	p.I137T	INADL_uc009waf.1_Missense_Mutation_p.I137T|INADL_uc001daa.2_Missense_Mutation_p.I137T|INADL_uc001dad.3_5'Flank	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	137	PDZ 1.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						TATATAGATATAGAACGGCCT	0.428													9	32					0	0	0	0	C	62234980	C	C	62234980	3	2	109	1	0	0	0	0	1	0	0	0	7770	1406	49	5	424	5	INADL	1	62234980	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	42601433	62234980	187015641	3	20132											
MCOLN2	255231	broad.mit.edu	37	chr1	85403472	85403472	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctaagacaatccagccaCagaatgtgtaacccagataa	16	7	7	11	0	0	3	0	0	0	3	2	3	2	3	4	0	2	1	4	0	5	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:85403472C>T	uc001dkm.2	-	11	1542	c.1301G>A	c.(1300-1302)TGT>TAT	p.C434Y	MCOLN2_uc001dkn.2_RNA	NM_153259	NP_694991	Q8IZK6	MCLN2_HUMAN	mucolipin 2	434	Helical; (Potential).					integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		AATCCAGCCACAGAATGTGTA	0.463													16	7					0	0	0	0	T	85403472	T	T	85403472	3	4	109	1	0	0	0	0	1	0	0	0	9449	478	17	4	415	4	MCOLN2	1	85403472	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	23168492	85403472	163847149	4	20133											
CELSR2	1952	broad.mit.edu	37	chr1	109801082	109801082	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacagcgtgaccgcccagtgCgcgctgcgtgtgaccatcat	7	7	12	15	5	1	2	1	2	0	0	1	2	1	2	3	0	3	1	3	0	0	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:109801082C>T	uc001dxa.3	+	2	3400	c.3339C>T	c.(3337-3339)TGC>TGT	p.C1113C		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1113	Cadherin 9.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCGCCCAGTGCGCGCTGCGTG	0.622													3	5					0	0	0	0	T	109801082	T	T	109801082	2	4	109	1	0	0	0	0	0	0	0	1	3237	776	27	1		1	CELSR2	1	109801082	Silent	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	24397610	109801082	139449539	5	20134											
RBM15	64783	broad.mit.edu	37	chr1	110884036	110884036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaacgtcactgcgctccttCtcctgaccgcagtccagaat	10	9	7	15	3	2	2	1	1	1	1	5	2	4	2	4	0	2	2	4	0	3	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:110884036C>T	uc001dzl.1	+	1	2092	c.2009C>T	c.(2008-2010)TCT>TTT	p.S670F	RBM15_uc001dzm.1_Missense_Mutation_p.S670F|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	670	Arg-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGCGCTCCTTCTCCTGACCGC	0.557			T	MKL1	acute megakaryocytic leukemia								19	29					0	0	0	0	T	110884036	T	T	110884036	3	4	109	1	0	0	0	0	1	0	0	0	13181	913	32	2	2011	2	RBM15	1	110884036	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	1082954	110884036	138366585	6	20135											
HRNR	388697	broad.mit.edu	37	chr1	152188022	152188022	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagctccatgttggccacagCtcgatgactgtcctgatgca	8	11	10	12	1	0	2	0	2	0	0	3	3	2	2	3	1	3	4	3	1	1	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:152188022C>G	uc001ezt.1	-	3	6159	c.6083G>C	c.(6082-6084)AGC>ACC	p.S2028T		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2028	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGGCCACAGCTCGATGACTG	0.562													60	858					0	0	0	0	G	152188022	G	G	152188022	3	3	109	1	0	0	0	0	1	0	0	0	7398	797	28	4	2473	4	HRNR	1	152188022	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	41303986	152188022	97062599	7	20136											
UBAP2L	9898	broad.mit.edu	37	chr1	154223543	154223543	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacccaagtgattcagcaGtgcacagcccctttacaaag	14	7	8	12	0	1	2	1	1	0	1	1	2	1	2	3	0	5	2	3	0	4	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:154223543G>A	uc001fep.3	+	13	1407	c.1240G>A	c.(1240-1242)GTG>ATG	p.V414M	UBAP2L_uc009wot.2_Missense_Mutation_p.V414M|UBAP2L_uc010pek.1_Missense_Mutation_p.V406M|UBAP2L_uc010pel.1_Missense_Mutation_p.V424M|UBAP2L_uc010pen.1_Missense_Mutation_p.V328M	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	414					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGATTCAGCAGTGCACAGCCC	0.483													32	54					0	0	0	0	A	154223543	A	A	154223543	3	1	109	1	0	0	0	0	1	0	0	0	16906	1029	36	4	1286	4	UBAP2L	1	154223543	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	2035521	154223543	95027078	8	20137											
IQGAP3	128239	broad.mit.edu	37	chr1	156510539	156510539	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaccagcaggccaatcttGatgtccatgatgttgaggtc	9	12	10	10	0	2	3	1	3	1	0	4	3	3	3	3	2	1	2	3	2	1	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:156510539G>T	uc001fpf.2	-	23	2775	c.2700C>A	c.(2698-2700)ATC>ATA	p.I900I		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	900					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGCCAATCTTGATGTCCATGA	0.562													30	31					3.73148e-12	6.88074e-12	1	0	T	156510539	T	T	156510539	2	4	109	1	0	0	0	0	0	0	0	1	7855	1280	45	2		2	IQGAP3	1	156510539	Silent	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	2286996	156510539	92740082	9	20138											
FCRL4	83417	broad.mit.edu	37	chr1	157559108	157559108	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggggtcagggtcaacttttCtccccagtagtgccgatgat	7	12	12	10	1	3	1	2	1	1	0	4	2	3	1	3	3	2	1	3	3	2	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:157559108C>T	uc001fqw.2	-	3	329	c.193G>A	c.(193-195)GAA>AAA	p.E65K	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	65	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GTCAACTTTTCTCCCCAGTAG	0.517													8	53					0	0	0	0	T	157559108	T	T	157559108	3	4	109	1	0	0	0	0	1	0	0	0	5829	922	32	2	1394	2	FCRL4	1	157559108	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	1048569	157559108	91691513	10	20139											
CD5L	922	broad.mit.edu	37	chr1	157805833	157805833	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcacaacacagccacgtcCttaatgtcccagccgtcatc	10	7	7	17	3	1	0	1	0	0	0	4	0	3	0	4	1	3	1	4	1	2	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:157805833C>A	uc001frk.3	-	3	311	c.168G>T	c.(166-168)AAG>AAT	p.K56N		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	56	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CAGCCACGTCCTTAATGTCCC	0.612													6	167					0.00116845	0.00199866	1	0	A	157805833	A	A	157805833	3	1	109	1	0	0	0	0	1	0	0	0	3042	680	24	4	891	4	CD5L	1	157805833	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	246725	157805833	91444788	11	20140											
ADAMTS4	9507	broad.mit.edu	37	chr1	161163765	161163765	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccatgtggaggcagcgaccaCccatgcaggcctgtgcgggc	7	5	15	14	2	0	0	0	0	0	0	0	2	0	1	4	4	3	2	4	4	0	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:161163765C>T	uc001fyt.3	-	5	1936	c.1508G>A	c.(1507-1509)GGT>GAT	p.G503D		NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	503	Disintegrin.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GCAGCGACCACCCATGCAGGC	0.652													20	21					0	0	0	0	T	161163765	T	T	161163765	3	4	109	1	0	0	0	0	1	0	0	0	268	507	18	4	1025	4	ADAMTS4	1	161163765	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	3357932	161163765	88086856	12	20141											
RC3H1	149041	broad.mit.edu	37	chr1	173915954	173915954	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaagctccccagccaccgtGggttccatatggactataat	11	9	9	12	1	0	1	0	0	0	1	2	2	2	2	5	2	2	2	5	2	4	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:173915954G>A	uc001gju.3	-	15	2845	c.2758C>T	c.(2758-2760)CAC>TAC	p.H920Y	RC3H1_uc010pms.1_Missense_Mutation_p.H920Y|RC3H1_uc001gjv.2_Missense_Mutation_p.H920Y|RC3H1_uc010pmt.1_Missense_Mutation_p.H920Y	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	920					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CAGCCACCGTGGGTTCCATAT	0.368													16	35					0	0	0	0	A	173915954	A	A	173915954	3	1	109	1	0	0	0	0	1	0	0	0	13231	1348	47	4	663	4	RC3H1	1	173915954	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	12752189	173915954	75334667	13	20142											
PLEKHA6	22874	broad.mit.edu	37	chr1	204226792	204226792	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccttccactctcgcagctGgtaggcagggccacccccat	6	8	9	18	1	1	0	0	0	1	0	4	0	3	0	5	3	1	4	5	3	1	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:204226792G>A	uc001hau.2	-	9	1530	c.1213C>T	c.(1213-1215)CAG>TAG	p.Q405*	PLEKHA6_uc009xaw.1_Nonsense_Mutation_p.Q29*|PLEKHA6_uc009xax.1_Nonsense_Mutation_p.Q29*|PLEKHA6_uc009xay.1_Nonsense_Mutation_p.Q29*|PLEKHA6_uc009xaz.1_Nonsense_Mutation_p.Q29*|PLEKHA6_uc009xba.1_Nonsense_Mutation_p.Q29*|PLEKHA6_uc009xbb.1_Nonsense_Mutation_p.Q29*|PLEKHA6_uc009xbc.1_Nonsense_Mutation_p.Q29*	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	405										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TCTCGCAGCTGGTAGGCAGGG	0.652													8	11					0	0	0	0	A	204226792	A	A	204226792	4	1	109	1	0	0	0	0	0	1	0	0	12115	1357	47	4	1989	4	PLEKHA6	1	204226792	Nonsense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	30310838	204226792	45023829	14	20143											
SLC41A1	254428	broad.mit.edu	37	chr1	205779508	205779508	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccatctgaagagcagggaGaggcagaagggccagtcccg	11	3	17	10	1	1	4	0	1	1	3	2	5	2	4	3	4	1	2	3	4	2	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:205779508G>A	uc001hdh.1	-	2	934	c.62C>T	c.(61-63)TCT>TTT	p.S21F		NM_173854	NP_776253	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 member 1	21						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			skin(2)	2	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			AGAGCAGGGAGAGGCAGAAGG	0.612											OREG0014163	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	39					0	0	0	0	A	205779508	A	A	205779508	3	1	109	1	0	0	0	0	1	0	0	0	14693	942	33	2	1519	2	SLC41A1	1	205779508	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	1552716	205779508	43471113	15	20144											
OR2AK2	391191	broad.mit.edu	37	chr1	248128809	248128809	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctctgacaggaaatatcaTgctgatccacctcattcgac	11	11	7	12	1	3	2	2	2	1	0	5	4	4	3	2	1	2	2	2	1	2	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr1:248128809T>C	uc010pzd.1	+	1	176	c.176T>C	c.(175-177)ATG>ACG	p.M59T	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	59	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GGAAATATCATGCTGATCCAC	0.448													18	221					0	0	0	0	C	248128809	C	C	248128809	3	2	109	1	0	0	0	0	1	0	0	0	11040	1464	51	5	178	5	OR2AK2	1	248128809	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	42349301	248128809	1121812	16	20145											
PRKD3	23683	broad.mit.edu	37	chr2	37501741	37501741	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accaacgaagtataccatagTatcagtaatgatttcaaaac	18	10	5	8	1	2	1	2	1	0	0	2	2	2	1	2	0	3	3	2	0	9	6			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:37501741T>A	uc002rqd.2	-	10	2029	c.1474A>T	c.(1474-1476)ACT>TCT	p.T492S	PRKD3_uc002rqe.1_Missense_Mutation_p.T92S|PRKD3_uc002rqf.1_Missense_Mutation_p.T492S	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	492	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				TATACCATAGTATCAGTAATG	0.423													26	28					0	0	0	0	A	37501741	A	A	37501741	3	1	109	1	0	0	0	0	1	0	0	0	12582	1638	57	5	1234	5	PRKD3	2	37501741	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08		37501741	205697632	17	20146											
ZNF638	27332	broad.mit.edu	37	chr2	71629115	71629115	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaatgtgtgtgatgcttgtCtctaatttgcctaataaagg	11	15	10	5	0	1	1	0	1	1	0	2	2	1	1	1	1	2	1	1	1	5	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:71629115C>G	uc002shx.2	+	16	3046	c.2727C>G	c.(2725-2727)GTC>GTG	p.V909V	ZNF638_uc010yqw.1_Silent_p.V488V|ZNF638_uc002shy.2_Silent_p.V909V|ZNF638_uc002shz.2_Silent_p.V909V|ZNF638_uc002sia.2_Silent_p.V909V|ZNF638_uc002sib.1_Silent_p.V909V|ZNF638_uc010fed.2_RNA|ZNF638_uc002sic.2_Silent_p.V6V	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	909	RRM 2.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TGATGCTTGTCTCTAATTTGC	0.269													18	34					0	0	0	0	G	71629115	G	G	71629115	2	3	109	1	0	0	0	0	0	0	0	1	18122	900	32	2		2	ZNF638	2	71629115	Silent	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	34127374	71629115	171570258	18	20147											
DYSF	8291	broad.mit.edu	37	chr2	71901427	71901427	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcctttgatgattttctggGtaagcgctattgctagaatc	8	16	9	8	1	1	3	0	2	1	1	3	3	2	3	1	1	2	3	1	1	4	7			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:71901427G>A	uc002sie.2	+	51	6143	c.5767_splice	c.e51+1	p.G1923_splice	DYSF_uc010feg.2_Splice_Site_p.G1954_splice|DYSF_uc010feh.2_Splice_Site_p.G1930_splice|DYSF_uc002sig.3_Splice_Site_p.G1909_splice|DYSF_uc010yqx.1_Splice_Site|DYSF_uc010fee.2_Splice_Site_p.G1944_splice|DYSF_uc010fef.2_Splice_Site_p.G1961_splice|DYSF_uc010fei.2_Splice_Site_p.G1940_splice|DYSF_uc010fek.2_Splice_Site_p.G1941_splice|DYSF_uc010fej.2_Splice_Site_p.G1931_splice|DYSF_uc010fel.2_Splice_Site_p.G1910_splice|DYSF_uc010feo.2_Splice_Site_p.G1955_splice|DYSF_uc010fem.2_Splice_Site_p.G1945_splice|DYSF_uc010fen.2_Splice_Site_p.G1962_splice|DYSF_uc002sif.2_Splice_Site_p.G1924_splice|DYSF_uc010yqy.1_Splice_Site_p.G804_splice|DYSF_uc010yqz.1_Splice_Site_p.G684_splice	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8							cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GATTTTCTGGGTAAGCGCTAT	0.522													15	28					0	0	0	0	A	71901427	A	A	71901427	5	1	109	1	0	0	0	0	0	0	1	0	4881	1275	44	4	6229	4	DYSF	2	71901427	Splice_Site	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	272312	71901427	171297946	19	20148											
TUBA3E	112714	broad.mit.edu	37	chr2	130949610	130949610	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcccaggcctccgcaatggCcgtggtgttgctcagcatgc	5	8	14	14	2	1	0	1	0	0	0	2	0	2	0	4	4	3	4	4	4	1	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:130949610C>T	uc002tqv.2	-	5	1248	c.1147G>A	c.(1147-1149)GCC>ACC	p.A383T		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	383					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					TCCGCAATGGCCGTGGTGTTG	0.632													48	84					0	0	0	0	T	130949610	T	T	130949610	3	4	109	1	0	0	0	0	1	0	0	0	16816	739	26	4	209	4	TUBA3E	2	130949610	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	59048183	130949610	112249763	20	20149											
RIF1	55183	broad.mit.edu	37	chr2	152266962	152266962	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggccaggggtcagagccccCtcgcgccgctgttggagact	5	6	15	15	4	1	2	1	0	0	2	2	3	1	2	4	4	1	2	4	4	0	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:152266962C>T	uc002txm.2	+	2	155	c.25C>T	c.(25-27)CTC>TTC	p.L9F	RIF1_uc002txl.2_Missense_Mutation_p.L9F|RIF1_uc010fnv.1_Intron|RIF1_uc002txn.2_Missense_Mutation_p.L9F|RIF1_uc002txo.2_Missense_Mutation_p.L9F|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	9					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TCAGAGCCCCCTCGCGCCGCT	0.652											OREG0015013	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	53					0	0	0	0	T	152266962	T	T	152266962	3	4	109	1	0	0	0	0	1	0	0	0	13424	681	24	4	27	4	RIF1	2	152266962	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	21317352	152266962	90932411	21	20150											
TTC21B	79809	broad.mit.edu	37	chr2	166764213	166764213	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtaatgcagtgatcgcatcaCcaagtttttccattttacta	11	15	6	9	1	1	1	1	1	0	0	3	1	2	1	2	0	2	4	2	0	4	6			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:166764213C>T	uc002udk.2	-	19	2676	c.2543G>A	c.(2542-2544)GGT>GAT	p.G848D		NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	848	TPR 12.					cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						GATCGCATCACCAAGTTTTTC	0.393													17	19					0	0	0	0	T	166764213	T	T	166764213	3	4	109	1	0	0	0	0	1	0	0	0	16756	507	18	4	1451	4	TTC21B	2	166764213	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	14497251	166764213	76435160	22	20151											
HECW2	57520	broad.mit.edu	37	chr2	197081812	197081812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattacaatatgattgtcatGgtatcctatcaaaccaatca	16	13	4	8	0	3	1	3	1	0	0	4	1	4	1	2	1	2	1	2	1	8	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:197081812G>A	uc002utm.1	-	27	4597	c.4414C>T	c.(4414-4416)CAT>TAT	p.H1472Y	HECW2_uc002utl.1_Missense_Mutation_p.H1116Y	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1472	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						TGATTGTCATGGTATCCTATC	0.388													11	100					0	0	0	0	A	197081812	A	A	197081812	3	1	109	1	0	0	0	0	1	0	0	0	7082	1348	47	4	316	4	HECW2	2	197081812	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	30317599	197081812	46117561	23	20152											
C2orf62	375307	broad.mit.edu	37	chr2	219221907	219221907	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcgacttcctcagctccCtccgtgagctcagacagtgt	7	10	8	16	2	2	2	2	1	0	1	6	3	5	2	4	0	2	2	4	0	0	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:219221907C>T	uc002vhr.2	+	2	144	c.115C>T	c.(115-117)CTC>TTC	p.L39F	C2orf62_uc002vhs.2_5'Flank	NM_198559	NP_940961	Q7Z7H3	CB062_HUMAN	hypothetical protein LOC375307	39											0		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTCAGCTCCCTCCGTGAGCT	0.547													23	38					0	0	0	0	T	219221907	T	T	219221907	3	4	109	1	0	0	0	0	1	0	0	0	2191	681	24	4	121	4	C2orf62	2	219221907	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	22140095	219221907	23977466	24	20153											
BCS1L	617	broad.mit.edu	37	chr2	219526164	219526164	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gattcgggtagaacgaagtcGagagatgcagatgatagact	14	8	14	5	3	0	5	0	1	0	4	2	9	0	5	0	1	2	2	0	1	4	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:219526164G>A	uc002vio.2	+	3	774	c.356G>A	c.(355-357)CGA>CAA	p.R119Q	ZNF142_uc002vin.2_5'Flank|ZNF142_uc010fvt.2_5'Flank|ZNF142_uc002vim.2_5'Flank|BCS1L_uc002vip.2_Missense_Mutation_p.R119Q|BCS1L_uc002viq.2_Missense_Mutation_p.R119Q|BCS1L_uc010fvu.2_Missense_Mutation_p.R119Q|BCS1L_uc010fvv.2_Missense_Mutation_p.R119Q|BCS1L_uc002vir.2_Missense_Mutation_p.R119Q|BCS1L_uc002vis.2_Missense_Mutation_p.R119Q	NM_004328	NP_004319	Q9Y276	BCS1_HUMAN	BCS1-like	119	Mitochondrial matrix (Potential).				mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAACGAAGTCGAGAGATGCAG	0.493													76	56					0	0	0	0	A	219526164	A	A	219526164	3	1	109	1	0	0	0	0	1	0	0	0	1391	1058	37	1	362	1	BCS1L	2	219526164	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	304257	219526164	23673209	25	20154											
STK36	27148	broad.mit.edu	37	chr2	219543897	219543897	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttctctctgtagaacttcCtgcagggactgctcaccaaa	9	13	7	12	0	3	1	1	0	2	1	5	2	4	2	2	1	3	3	2	1	3	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:219543897C>T	uc002viu.2	+	7	957	c.691C>T	c.(691-693)CTG>TTG	p.L231L	STK36_uc002viv.2_Silent_p.L231L	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	231	Protein kinase.				cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GTAGAACTTCCTGCAGGGACT	0.478													39	85					0	0	0	0	T	219543897	T	T	219543897	2	4	109	1	0	0	0	0	0	0	0	1	15368	680	24	4		4	STK36	2	219543897	Silent	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	17733	219543897	23655476	26	20155											
CHRND	1144	broad.mit.edu	37	chr2	233399048	233399048	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagggaccagaacaattacaAtgaggtaagggaccacagga	17	4	13	7	0	0	2	0	1	0	1	0	6	0	5	2	4	2	1	2	4	5	2	rs144433265		TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:233399048A>C	uc002vsw.2	+	11	1371	c.1367A>C	c.(1366-1368)AAT>ACT	p.N456T	CHRND_uc010zmg.1_Missense_Mutation_p.N441T|CHRND_uc010fyc.2_Missense_Mutation_p.N329T|CHRND_uc010zmh.1_Missense_Mutation_p.N262T	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	456	Cytoplasmic (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		AACAATTACAATGAGGTAAGG	0.488													7	98					0	0	0	0	C	233399048	C	C	233399048	3	2	109	1	0	0	0	0	1	0	0	0	3409	101	4	5	1409	5	CHRND	2	233399048	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	13855151	233399048	9800325	27	20156											
USP40	55230	broad.mit.edu	37	chr2	234460155	234460155	+	Nonsense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaaaggaggcagcttacgtAatttggccgactgttaaaag	14	9	12	6	2	0	0	0	0	0	0	0	3	0	1	1	3	2	4	1	3	6	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr2:234460155A>C	uc010zmu.1	-	7	822	c.704T>G	c.(703-705)TTA>TGA	p.L235*	USP40_uc010zmr.1_Nonsense_Mutation_p.L247*|USP40_uc010zmt.1_5'Flank			Q9NVE5	UBP40_HUMAN	SubName: Full=cDNA FLJ56772, highly similar to Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15);	235					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CAGCTTACGTAATTTGGCCGA	0.308													11	9					0	0	0	0	C	234460155	C	C	234460155	4	2	109	1	0	0	0	0	0	1	0	0	17140	372	13	5	3107	5	USP40	2	234460155	Nonsense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	1061107	234460155	8739218	28	20157											
CAMK1	8536	broad.mit.edu	37	chr3	9807481	9807481	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattctccatgctgccttcCttgccctccagggcctcctt	3	14	6	18	0	2	0	1	0	1	0	6	0	5	0	7	1	3	1	7	1	0	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr3:9807481C>T	uc003bst.2	-	3	355	c.177G>A	c.(175-177)AAG>AAA	p.K59K	OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|CAMK1_uc003bsu.2_RNA	NM_003656	NP_003647	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	59	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|skin(1)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		TGCTGCCTTCCTTGCCCTCCA	0.527													29	6					0	0	0	0	T	9807481	T	T	9807481	2	4	109	1	0	0	0	0	0	0	0	1	2608	680	24	4		4	CAMK1	3	9807481	Silent	SNP	C	TCGA-CQ-6228-01A-11D-1912-08		9807481	188214949	29	20158											
IMPDH2	3615	broad.mit.edu	37	chr3	49063994	49063999	+	In_Frame_Del	DEL	TGTACT	-	-																															attagggtatttgtctttgaTgtacttgatcatattgatct																										TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr3:49063994_49063999delTGTACT	uc003cvt.2	-	8	955_960	c.863_868delAGTACA	c.(862-870)AAGTACATC>ATC	p.KY288del		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	288_289					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	TTGTCTTTGATGTACTTGATCATATT	0.485													---	---	---								-	49063999	-	-	49063994	7	5	109	1	0	1	0	1	0	0	0	0	7766	1464	51	0	704	0	IMPDH2	3	49063994	In_Frame_Del	DEL	TGTACT	TCGA-CQ-6228-01A-11D-1912-08	39256513	49063994	148958436	30	20159											
USP19	10869	broad.mit.edu	37	chr3	49151435	49151435	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaaagatacctccgccaaaCgcaggttctcaggcttcaca	13	7	7	14	2	2	1	2	0	1	1	4	1	3	1	3	2	2	3	3	2	3	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr3:49151435C>T	uc003cwd.1	-	16	2347	c.2186G>A	c.(2185-2187)CGT>CAT	p.R729H	USP19_uc003cwa.2_Missense_Mutation_p.R537H|USP19_uc003cvz.3_Missense_Mutation_p.R832H|USP19_uc011bcg.1_Missense_Mutation_p.R820H|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_Missense_Mutation_p.R487H|USP19_uc011bch.1_Missense_Mutation_p.R830H	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	729	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTCCGCCAAACGCAGGTTCTC	0.512													7	21					0	0	0	0	T	49151435	T	T	49151435	3	4	109	1	0	0	0	0	1	0	0	0	17118	536	19	1	1814	1	USP19	3	49151435	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	87441	49151435	148870995	31	20160											
USP19	10869	broad.mit.edu	37	chr3	49154907	49154907	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgagcataggcacctttttgGgcagtgtcaggtgcaggaga	9	10	15	7	0	1	2	1	1	0	1	1	3	1	2	1	4	2	4	1	4	1	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr3:49154907G>T	uc003cwd.1	-	5	730	c.569C>A	c.(568-570)CCC>CAC	p.P190H	USP19_uc003cwa.2_5'UTR|USP19_uc003cvz.3_Missense_Mutation_p.P190H|USP19_uc011bcg.1_Missense_Mutation_p.P190H|USP19_uc003cwb.2_Missense_Mutation_p.P175H|USP19_uc003cwc.1_5'Flank|USP19_uc011bch.1_Missense_Mutation_p.P190H|USP19_uc011bci.1_Missense_Mutation_p.P175H	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	190	Cytoplasmic (Potential).|CS 1.				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CACCTTTTTGGGCAGTGTCAG	0.552													31	10					1.75199e-13	3.25369e-13	1	0	T	49154907	T	T	49154907	3	4	109	1	0	0	0	0	1	0	0	0	17118	1232	43	4	3475	4	USP19	3	49154907	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	3472	49154907	148867523	32	20161											
PLA1A	51365	broad.mit.edu	37	chr3	119331938	119331938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctggagatgccctcttcGtggaagccatccacacagac	10	8	10	13	1	1	2	0	0	1	2	3	4	2	3	3	2	3	1	3	2	1	1	rs140761557		TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr3:119331938G>A	uc003ecu.2	+	5	676	c.637G>A	c.(637-639)GTG>ATG	p.V213M	PLA1A_uc003ecv.2_Missense_Mutation_p.V197M|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_Missense_Mutation_p.V40M	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	213				V -> T (in Ref. 4; BAD96425).	lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						TGCCCTCTTCGTGGAAGCCAT	0.572													11	11					0	0	0	0	A	119331938	A	A	119331938	3	1	109	1	0	0	0	0	1	0	0	0	12043	1145	40	1	655	1	PLA1A	3	119331938	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	70177031	119331938	78690492	33	20162											
GOLGB1	2804	broad.mit.edu	37	chr3	121410533	121410533	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctgaagttgaacttcaaGaagctgcttttgttggctgt	8	16	11	6	0	1	3	1	2	0	1	1	3	1	3	0	1	4	6	0	1	4	6			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr3:121410533G>T	uc003eei.3	-	14	7789	c.7663C>A	c.(7663-7665)CTT>ATT	p.L2555I	GOLGB1_uc010hrc.2_Missense_Mutation_p.L2560I|GOLGB1_uc003eej.3_Missense_Mutation_p.L2521I	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2555	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TGAACTTCAAGAAGCTGCTTT	0.388													88	66					3.1376e-36	6.08789e-36	1	0	T	121410533	T	T	121410533	3	4	109	1	0	0	0	0	1	0	0	0	6602	942	33	2	2152	2	GOLGB1	3	121410533	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	2078595	121410533	76611897	34	20163											
DNAJC13	23317	broad.mit.edu	37	chr3	132185174	132185174	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctggcatacttggaaagctCagatctcgtacctgagaagg	11	9	12	9	1	2	2	1	1	1	2	3	4	2	3	1	3	3	4	1	3	4	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr3:132185174C>G	uc003eor.2	+	19	2065	c.2000C>G	c.(1999-2001)TCA>TGA	p.S667*	DNAJC13_uc010htq.1_Nonsense_Mutation_p.S667*	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	667							heat shock protein binding			ovary(1)|breast(1)	2						TTGGAAAGCTCAGATCTCGTA	0.378													21	57					0	0	0	0	G	132185174	G	G	132185174	4	3	109	1	0	0	0	0	0	1	0	0	4654	838	29	2	2070	2	DNAJC13	3	132185174	Nonsense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	10774641	132185174	65837256	35	20164											
C4orf50	389197	broad.mit.edu	37	chr4	5961272	5961272	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccgcctttttcttgcagacGttgtgcggggagacctggtt	4	14	13	10	3	1	2	0	0	1	2	2	3	2	2	3	3	2	3	3	3	0	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr4:5961272G>A	uc003git.1	-	7	751	c.661C>T	c.(661-663)CGT>TGT	p.R221C		NM_207405	NP_997288	Q6ZRC1	CD050_HUMAN	hypothetical protein LOC389197	221										pancreas(2)|breast(1)	3						TCTTGCAGACGTTGTGCGGGG	0.587													21	32					0	0	0	0	A	5961272	A	A	5961272	3	1	109	1	0	0	0	0	1	0	0	0	2286	1145	40	1	173	1	C4orf50	4	5961272	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08		5961272	185193004	36	20165											
SLC34A2	10568	broad.mit.edu	37	chr4	25676210	25676210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccaccgccatcctggccGccttagccagccctggcaat	7	6	8	20	2	0	0	0	0	0	0	1	0	1	0	9	2	2	1	9	2	2	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr4:25676210G>A	uc003grr.2	+	12	1498	c.1417G>A	c.(1417-1419)GCC>ACC	p.A473T	SLC34A2_uc003grs.2_Missense_Mutation_p.A472T|SLC34A2_uc010iev.2_Missense_Mutation_p.A472T	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	473	Extracellular (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				CATCCTGGCCGCCTTAGCCAG	0.607													49	60					0	0	0	0	A	25676210	A	A	25676210	3	1	109	1	0	0	0	0	1	0	0	0	14632	1087	38	1	1459	1	SLC34A2	4	25676210	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	19714938	25676210	165478066	37	20166											
NPFFR2	10886	broad.mit.edu	37	chr4	72994497	72994497	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttttgtgcatgatgggaaaTactgtggtttgctttattgt	7	20	11	3	0	0	1	0	1	0	0	0	2	0	2	0	2	3	3	0	2	3	7			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr4:72994497T>G	uc003hgg.2	+	2	593	c.495T>G	c.(493-495)AAT>AAG	p.N165K	NPFFR2_uc010iig.1_Intron|NPFFR2_uc003hgi.2_Missense_Mutation_p.N66K|NPFFR2_uc003hgh.2_Missense_Mutation_p.N63K	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	165	Helical; Name=1; (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TGATGGGAAATACTGTGGTTT	0.358													40	51					0	0	0	0	G	72994497	G	G	72994497	3	3	109	1	0	0	0	0	1	0	0	0	10632	1403	49	5	507	5	NPFFR2	4	72994497	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	47318287	72994497	118159779	38	20167											
PRMT10	90826	broad.mit.edu	37	chr4	148559781	148559781	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgggattatctaaaacaaCtgcagcttgtttccagtggg	11	12	11	7	0	1	0	0	0	1	0	2	2	2	1	1	2	4	3	1	2	4	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr4:148559781C>T	uc003ilc.2	-	12	2582	c.2440G>A	c.(2440-2442)GTT>ATT	p.V814I	PRMT10_uc003ilb.2_Missense_Mutation_p.V458I|PRMT10_uc003ild.2_Missense_Mutation_p.V701I	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	814						cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						TCTAAAACAACTGCAGCTTGT	0.413													20	20					0	0	0	0	T	148559781	T	T	148559781	3	4	109	1	0	0	0	0	1	0	0	0	12598	565	20	4	101	4	PRMT10	4	148559781	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	75565284	148559781	42594495	39	20168											
KLHL2	11275	broad.mit.edu	37	chr4	166238995	166238995	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggagtttgtgcagttaatGgtctgttatatgttgttgga	9	17	13	2	0	1	0	0	0	1	0	1	2	1	2	0	3	1	6	0	3	4	6			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr4:166238995G>T	uc003irb.2	+	14	1886	c.1627G>T	c.(1627-1629)GGT>TGT	p.G543C	KLHL2_uc011cjm.1_Missense_Mutation_p.G547C|KLHL2_uc003irc.2_Missense_Mutation_p.G455C|KLHL2_uc010ira.2_Missense_Mutation_p.G196C	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	543	Kelch 5.				intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		TGCAGTTAATGGTCTGTTATA	0.348													26	12					5.61819e-17	1.06623e-16	1	0	T	166238995	T	T	166238995	3	4	109	1	0	0	0	0	1	0	0	0	8413	1348	47	4	1723	4	KLHL2	4	166238995	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	17679214	166238995	24915281	40	20169											
IRX4	50805	broad.mit.edu	37	chr5	1879828	1879828	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgatgatggccagcatgaTcttctcgcccttggtggggt	5	12	15	9	1	2	3	0	3	2	0	3	3	2	3	2	5	1	1	2	5	0	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr5:1879828T>C	uc003jcz.2	-	4	645	c.526A>G	c.(526-528)ATC>GTC	p.I176V	IRX4_uc011cmf.1_Missense_Mutation_p.I37V	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	176	Homeobox; TALE-type.				heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		GCCAGCATGATCTTCTCGCCC	0.642													35	53					0	0	0	0	C	1879828	C	C	1879828	3	2	109	1	0	0	0	0	1	0	0	0	7885	1435	50	5	1041	5	IRX4	5	1879828	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08		1879828	179035432	41	20170											
DNAH5	1767	broad.mit.edu	37	chr5	13830247	13830247	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaataatggaaatttgctggGctgcaaccgagagaactggt	13	9	13	6	1	0	1	0	0	0	1	0	5	0	2	1	3	4	3	1	3	5	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr5:13830247G>C	uc003jfd.2	-	37	6179	c.6137C>G	c.(6136-6138)GCC>GGC	p.A2046G		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2046	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AATTTGCTGGGCTGCAACCGA	0.383									Kartagener_syndrome				20	20					0	0	0	0	C	13830247	C	C	13830247	3	2	109	1	0	0	0	0	1	0	0	0	4626	1203	42	4	7909	4	DNAH5	5	13830247	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	11950419	13830247	167085013	42	20171											
IL7R	3575	broad.mit.edu	37	chr5	35876219	35876219	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caactagaagaatctgagaaGcagaggcttggaggggatgt	14	7	15	5	0	1	4	0	1	1	4	1	7	1	6	0	4	2	2	0	4	5	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr5:35876219G>T	uc003jjs.2	+	8	1100	c.1011G>T	c.(1009-1011)AAG>AAT	p.K337N	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	337	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AATCTGAGAAGCAGAGGCTTG	0.488													15	38					4.14922e-12	7.59716e-12	1	0	T	35876219	T	T	35876219	3	4	109	1	0	0	0	0	1	0	0	0	7744	962	34	4	1041	4	IL7R	5	35876219	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	22045972	35876219	145039041	43	20172											
ELL2	22936	broad.mit.edu	37	chr5	95242283	95242283	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgattgacaccatctttctGgagtctagcaagtagctccg	9	13	9	10	1	3	2	0	2	3	0	4	3	4	3	2	1	2	3	2	1	3	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr5:95242283G>T	uc003klr.3	-	5	1035	c.685C>A	c.(685-687)CAG>AAG	p.Q229K		NM_012081	NP_036213	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	229					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		CCATCTTTCTGGAGTCTAGCA	0.502													14	122					4.3838e-07	7.70127e-07	1	0	T	95242283	T	T	95242283	3	4	109	1	0	0	0	0	1	0	0	0	5087	1357	47	4	1269	4	ELL2	5	95242283	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	59366064	95242283	85672977	44	20173											
FBN2	2201	broad.mit.edu	37	chr5	127670501	127670501	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctcacattccccaaacaTgcagatatttgaatttaggt	12	14	6	9	0	1	2	1	1	1	1	3	2	2	2	2	1	2	2	2	1	4	6			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr5:127670501T>A	uc003kuu.2	-	31	4448	c.4009A>T	c.(4009-4011)ATG>TTG	p.M1337L	FBN2_uc003kuv.2_Missense_Mutation_p.M1304L	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1337	EGF-like 21; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCCCCAAACATGCAGATATTT	0.378													27	37					0	0	0	0	A	127670501	A	A	127670501	3	1	109	1	0	0	0	0	1	0	0	0	5735	1464	51	5	4869	5	FBN2	5	127670501	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	32428218	127670501	53244759	45	20174											
PCDHB6	56130	broad.mit.edu	37	chr5	140529803	140529803	+	5'Flank	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtggtgattgggagctgAaaaggatttttcttccgtat	9	15	13	4	1	1	2	0	2	1	0	2	5	2	4	1	3	1	2	1	3	3	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr5:140529803A>C	uc003lir.2	+						PCDHB6_uc011dah.1_5'UTR	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor						calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTGGGAGCTGAAAAGGATTTT	0.413													11	14					0	0	0	0	C	140529803	C	C	140529803	1	2	109	0	1	0	0	0	0	0	0	0	11600	261	9	5		5	PCDHB6	5	140529803	5'Flank	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	12859302	140529803	40385457	46	20175											
PRELID1	27166	broad.mit.edu	37	chr5	176732933	176732933	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtggctggactgaaatccGccgggaagcctgggtctcct	7	8	14	12	2	1	1	0	1	1	0	3	3	2	3	4	4	1	1	4	4	2	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr5:176732933G>T	uc003mfx.2	+	3	532	c.380G>T	c.(379-381)CGC>CTC	p.R127L	RAB24_uc003mfu.2_5'Flank|RAB24_uc003mfv.2_5'Flank|RAB24_uc003mfw.2_5'Flank|PRELID1_uc003mfy.2_Missense_Mutation_p.R127L|MXD3_uc010jkk.2_3'UTR	NM_013237	NP_037369	Q9Y255	PRLD1_HUMAN	PRELI domain containing 1 precursor	127	PRELI/MSF1.			R -> H (in Ref. 1; AAF09255).	immune response|multicellular organismal development	mitochondrion|nucleus					0	all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACTGAAATCCGCCGGGAAGCC	0.547													24	36					3.6726e-16	6.9194e-16	1	0	T	176732933	T	T	176732933	3	4	109	1	0	0	0	0	1	0	0	0	12533	1087	38	3	390	3	PRELID1	5	176732933	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	36203130	176732933	4182327	47	20176											
HIST1H2BD	3017	broad.mit.edu	37	chr6	26158375	26158375	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctcaggtgtttgcaacaGtgttctaactattaacgcta	10	16	7	8	1	2	0	1	0	2	0	3	0	2	0	0	1	4	4	0	1	5	7			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr6:26158375G>A	uc003ngr.2	+	1	27	c.-22G>A	c.(-24--20)CAGTG>CAATG		HIST1H2BD_uc003ngs.2_Translation_Start_Site	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd						nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						GTTTGCAACAGTGTTCTAACT	0.458													34	32					0	0	0	0	A	26158375	A	A	26158375	1	1	109	1	0	0	0	0	0	0	0	0	7182	1044	36	4		4	HIST1H2BD	6	26158375	Translation_Start_Site	SNP	G	TCGA-CQ-6228-01A-11D-1912-08		26158375	144956692	48	20177											
TDRD6	221400	broad.mit.edu	37	chr6	46656253	46656253	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcggaagtgctgggctgcGtgctagcgggcctggtgccg	3	8	18	12	4	0	0	0	0	0	0	1	1	0	1	3	4	5	3	3	4	2	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr6:46656253G>A	uc003oyj.2	+	1	388	c.388G>A	c.(388-390)GTG>ATG	p.V130M	TDRD6_uc010jze.2_Missense_Mutation_p.V124M	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	130					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GCTGGGCTGCGTGCTAGCGGG	0.706													5	6					0	0	0	0	A	46656253	A	A	46656253	3	1	109	1	0	0	0	0	1	0	0	0	15800	1145	40	1	390	1	TDRD6	6	46656253	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	20497878	46656253	124458814	49	20178											
SFRS18	25957	broad.mit.edu	37	chr6	99848618	99848618	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtagtacttttcttactaTcctgtctagaatcatgtctt	8	19	6	8	0	4	1	1	0	3	1	5	1	5	1	1	1	2	2	1	1	6	8			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr6:99848618T>A	uc003ppo.3	-	12	2444	c.2216A>T	c.(2215-2217)GAT>GTT	p.D739V	SFRS18_uc003ppl.2_Missense_Mutation_p.D285V|SFRS18_uc003ppp.3_Missense_Mutation_p.D739V|SFRS18_uc011eag.1_Missense_Mutation_p.D739V	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	739	Ser-rich.					nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)		TTTCTTACTATCCTGTCTAGA	0.353													44	80					0	0	0	0	A	99848618	A	A	99848618	3	1	109	1	0	0	0	0	1	0	0	0	14239	1435	50	5	205	5	SFRS18	6	99848618	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	53192365	99848618	71266449	50	20179											
C6orf170	221322	broad.mit.edu	37	chr6	121615732	121615732	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttactgcaatgctttgaatgTcccaaagtttcatcagcttt	10	16	6	9	0	2	1	2	1	0	0	3	1	3	1	1	0	4	4	1	0	4	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr6:121615732T>C	uc003pyo.1	-	11	1283	c.1215A>G	c.(1213-1215)GGA>GGG	p.G405G	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_5'Flank	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	405					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		GCTTTGAATGTCCCAAAGTTT	0.279													58	74					0	0	0	0	C	121615732	C	C	121615732	2	2	109	1	0	0	0	0	0	0	0	1	2354	1654	58	5		5	C6orf170	6	121615732	Silent	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	21767114	121615732	49499335	51	20180											
MTHFD1L	25902	broad.mit.edu	37	chr6	151293090	151293090	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcacttctctaggggacacCtgtgttcgtgcatgcgggcc	5	12	12	12	2	2	0	1	0	1	0	4	1	2	1	2	3	2	2	2	3	1	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr6:151293090C>A	uc003qob.2	+	20	2289	c.2021C>A	c.(2020-2022)CCT>CAT	p.P674H	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Missense_Mutation_p.P675H|MTHFD1L_uc003qoc.2_Missense_Mutation_p.P622H	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	674	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		TAGGGGACACCTGTGTTCGTG	0.443													17	76					1.50039e-11	2.72798e-11	1	0	A	151293090	A	A	151293090	3	1	109	1	0	0	0	0	1	0	0	0	9981	681	24	4	2099	4	MTHFD1L	6	151293090	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	29677358	151293090	19821977	52	20181											
TMEM195	392636	broad.mit.edu	37	chr7	15584411	15584411	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttaccatgagccatacgaTggaaccagtagtagccaaag	14	7	10	10	1	0	1	0	1	0	0	0	3	0	2	4	1	5	3	4	1	6	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr7:15584411T>G	uc003stb.1	-	3	565	c.395A>C	c.(394-396)CAT>CCT	p.H132P		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	132	Histidine box-1.			H->A: Loss of function; when associated with A-136; A-145; A-148; A-149; A-221; A-224 and A-225.	ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						AGCCATACGATGGAACCAGTA	0.318													6	100					0	0	0	0	G	15584411	G	G	15584411	3	3	109	1	0	0	0	0	1	0	0	0	16183	1464	51	5	986	5	TMEM195	7	15584411	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08		15584411	143554252	53	20182											
PRPS1L1	221823	broad.mit.edu	37	chr7	18067176	18067176	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctagctgaagcaatcttgCaggcattaatcatgatcaaa	14	10	9	8	0	3	2	2	2	1	0	3	2	3	2	0	2	3	5	0	2	5	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr7:18067176C>A	uc003stz.2	-	1	311	c.230G>T	c.(229-231)TGC>TTC	p.C77F		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	77					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					AGCAATCTTGCAGGCATTAAT	0.483													110	164					5.77253e-36	1.11175e-35	1	0	A	18067176	A	A	18067176	3	1	109	1	0	0	0	0	1	0	0	0	12641	710	25	4	730	4	PRPS1L1	7	18067176	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	2482765	18067176	141071487	54	20183											
POU6F2	11281	broad.mit.edu	37	chr7	39472771	39472771	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgcagccaatcaccccccaGctcctcacaaacgcccaggg	10	4	8	19	1	2	0	2	0	0	0	3	0	3	0	6	1	4	2	6	1	2	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr7:39472771G>A	uc003thb.1	+	7	1164	c.1122G>A	c.(1120-1122)CAG>CAA	p.Q374Q		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	374	Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						TCACCCCCCAGCTCCTCACAA	0.587													5	59					0	0	0	0	A	39472771	A	A	39472771	2	1	109	1	0	0	0	0	0	0	0	1	12340	962	34	4		4	POU6F2	7	39472771	Silent	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	21405595	39472771	119665892	55	20184											
NPC1L1	29881	broad.mit.edu	37	chr7	44578580	44578580	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtccggattgaggggggcGtagcagatgtcctgcaggga	7	9	18	7	2	0	2	0	1	0	1	2	4	2	4	2	5	2	3	2	5	1	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr7:44578580G>A	uc003tlb.2	-	2	1472	c.1416C>T	c.(1414-1416)TAC>TAT	p.Y472Y	NPC1L1_uc003tlc.2_Silent_p.Y472Y|NPC1L1_uc011kbw.1_Silent_p.Y472Y|NPC1L1_uc003tld.2_Silent_p.Y472Y	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	472	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	TGAGGGGGGCGTAGCAGATGT	0.592													12	26					0	0	0	0	A	44578580	A	A	44578580	2	1	109	1	0	0	0	0	0	0	0	1	10625	1140	40	1		1	NPC1L1	7	44578580	Silent	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	5105809	44578580	114560083	56	20185											
ELN	2006	broad.mit.edu	37	chr7	73480043	73480043	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtatacctccagctgcagcCgctaaagcagctaaatacgg	12	7	10	12	2	0	0	0	0	0	0	1	0	1	0	3	2	7	6	3	2	7	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr7:73480043C>T	uc003tzw.2	+	30	2122	c.2031C>T	c.(2029-2031)GCC>GCT	p.A677A	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Silent_p.A671A|ELN_uc003tzz.2_Silent_p.A590A|ELN_uc003tzo.2_Silent_p.A623A|ELN_uc003tzp.2_Silent_p.A582A|ELN_uc003tzq.2_Silent_p.A535A|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_Silent_p.A652A|ELN_uc003tzt.2_Silent_p.A676A|ELN_uc003tzu.2_Silent_p.A657A|ELN_uc003tzv.2_Silent_p.A642A|ELN_uc003tzx.2_Silent_p.A661A|ELN_uc011kff.1_Silent_p.A671A|ELN_uc003tzy.2_Silent_p.A647A	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	733	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CAGCTGCAGCCGCTAAAGCAG	0.547			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						15	24					0	0	0	0	T	73480043	T	T	73480043	2	4	109	1	0	0	0	0	0	0	0	1	5095	639	23	1		1	ELN	7	73480043	Silent	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	28901463	73480043	85658620	57	20186											
MAGI2	9863	broad.mit.edu	37	chr7	77885383	77885383	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaacaatgaggtcgccttCacacaggccagggcatccct	10	7	9	15	1	2	1	2	1	0	0	4	1	3	1	3	3	1	1	3	3	2	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr7:77885383C>T	uc003ugx.2	-	10	2178	c.1924G>A	c.(1924-1926)GAA>AAA	p.E642K	MAGI2_uc003ugy.2_Missense_Mutation_p.E642K|MAGI2_uc010ldx.1_Missense_Mutation_p.E251K|MAGI2_uc010ldy.1_Missense_Mutation_p.E251K|MAGI2_uc011kgr.1_Missense_Mutation_p.E474K|MAGI2_uc011kgs.1_Missense_Mutation_p.E479K	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	642	PDZ 3.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AGGTCGCCTTCACACAGGCCA	0.493													10	12					0	0	0	0	T	77885383	T	T	77885383	3	4	109	1	0	0	0	0	1	0	0	0	9244	835	29	2	2495	2	MAGI2	7	77885383	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	4405340	77885383	81253280	58	20187											
PDK4	5166	broad.mit.edu	37	chr7	95224465	95224465	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaagaagttctttcacatgCattttctgaacctataataa	16	14	4	7	0	3	2	1	1	2	1	3	2	3	2	1	0	2	2	1	0	7	7			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr7:95224465C>A	uc003uoa.2	-	2	462	c.142G>T	c.(142-144)GCA>TCA	p.A48S	PDK4_uc003unz.2_5'Flank	NM_002612	NP_002603	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase 4 precursor	48					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity				0	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			CTTTCACATGCATTTTCTGAA	0.318													10	25					0.000442599	0.000762092	1	0	A	95224465	A	A	95224465	3	1	109	1	0	0	0	0	1	0	0	0	11732	710	25	4	1133	4	PDK4	7	95224465	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	17339082	95224465	63914198	59	20188											
RELN	5649	broad.mit.edu	37	chr7	103179606	103179606	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcacggcaacgtctgtgcTgaccacgtaacgggtgctgg	8	9	13	11	4	2	1	1	1	1	0	2	1	2	1	1	3	4	4	1	3	2	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr7:103179606T>C	uc003vca.2	-	45	7259	c.7099A>G	c.(7099-7101)AGC>GGC	p.S2367G	RELN_uc010liz.2_Missense_Mutation_p.S2367G	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2367					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACGTCTGTGCTGACCACGTAA	0.542													3	45					0	0	0	0	C	103179606	C	C	103179606	3	2	109	1	0	0	0	0	1	0	0	0	13285	1580	55	5	3367	5	RELN	7	103179606	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	7955141	103179606	55959057	60	20189											
NRCAM	4897	broad.mit.edu	37	chr7	107880402	107880402	+	Splice_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctttaaaacgttaatacttaCgatcaagaggtacttccagt	14	13	6	8	2	1	1	1	0	0	1	2	2	2	1	1	1	4	2	1	1	7	7			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr7:107880402C>T	uc003vfb.2	-	4	577	c.106_splice	c.e4+1	p.P36_splice	NRCAM_uc003vfc.2_Splice_Site_p.L36_splice|NRCAM_uc011kmk.1_Splice_Site_p.P31_splice|NRCAM_uc003vfd.2_Splice_Site_p.P31_splice|NRCAM_uc003vfe.2_Splice_Site_p.P31_splice	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A						angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TTAATACTTACGATCAAGAGG	0.453													28	42					0	0	0	0	T	107880402	T	T	107880402	5	4	109	1	0	0	0	0	0	0	1	0	10698	550	19	1	3957	1	NRCAM	7	107880402	Splice_Site	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	4700796	107880402	51258261	61	20190											
LGI3	203190	broad.mit.edu	37	chr8	22009005	22009005	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agattgggcgcaggtacctgGgattctatcatagtctcgaa	10	11	12	8	2	3	1	1	0	2	1	4	3	3	2	1	3	1	2	1	3	4	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr8:22009005G>T	uc003xav.2	-	7	1115	c.826C>A	c.(826-828)CCA>ACA	p.P276T	LGI3_uc010ltu.2_Missense_Mutation_p.P252T	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	276	EAR 2.				exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CAGGTACCTGGGATTCTATCA	0.522													5	96					2.0095e-06	3.50651e-06	1	0	T	22009005	T	T	22009005	3	4	109	1	0	0	0	0	1	0	0	0	8794	1232	43	4	828	4	LGI3	8	22009005	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08		22009005	124355017	62	20191											
TRIM55	84675	broad.mit.edu	37	chr8	67039641	67039641	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccttgtcagcacaacctGtgtaggaaatgtgccagtga	10	10	10	11	0	1	1	1	1	0	0	2	2	2	2	3	1	3	2	3	1	3	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr8:67039641G>T	uc003xvv.2	+	1	364	c.138G>T	c.(136-138)CTG>CTT	p.L46L	TRIM55_uc003xvu.2_Silent_p.L46L|TRIM55_uc003xvw.2_Silent_p.L46L|TRIM55_uc003xvx.2_Silent_p.L46L	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	46	RING-type.					cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			AGCACAACCTGTGTAGGAAAT	0.463													5	206					2.7689e-08	4.93091e-08	1	0	T	67039641	T	T	67039641	2	4	109	1	0	0	0	0	0	0	0	1	16596	1364	48	4		4	TRIM55	8	67039641	Silent	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	45030636	67039641	79324381	63	20192											
CSMD3	114788	broad.mit.edu	37	chr8	113304927	113304927	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaattggactaccagggtgaCcacagctaacagctaataag	16	7	9	9	0	0	1	0	1	0	0	0	2	0	2	2	2	4	2	2	2	5	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr8:113304927C>T	uc003ynu.2	-	55	8786	c.8627G>A	c.(8626-8628)GGT>GAT	p.G2876D	CSMD3_uc003yns.2_Missense_Mutation_p.G2078D|CSMD3_uc003ynt.2_Missense_Mutation_p.G2836D|CSMD3_uc011lhx.1_Missense_Mutation_p.G2707D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2876	Extracellular (Potential).|Sushi 19.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACCAGGGTGACCACAGCTAAC	0.363										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	74					0	0	0	0	T	113304927	T	T	113304927	3	4	109	1	0	0	0	0	1	0	0	0	3963	507	18	4	2564	4	CSMD3	8	113304927	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	46265286	113304927	33059095	64	20193											
TAF1L	138474	broad.mit.edu	37	chr9	32631631	32631631	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaactcctcctcctgctctTctgtcatggcaacaggtttc	6	13	6	16	0	3	0	1	0	2	0	7	0	6	0	4	2	3	3	4	2	2	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr9:32631631T>A	uc003zrg.1	-	1	4037	c.3947A>T	c.(3946-3948)GAA>GTA	p.E1316V	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1316					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CTCCTGCTCTTCTGTCATGGC	0.428													119	39					0	0	0	0	A	32631631	A	A	32631631	3	1	109	1	0	0	0	0	1	0	0	0	15589	1783	62	5	1537	5	TAF1L	9	32631631	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08		32631631	108581800	65	20194											
ZBTB6	10773	broad.mit.edu	37	chr9	125673155	125673155	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccatggacagaggttaagtgCtttttgagagcagacttgtg	10	12	13	6	0	0	3	0	1	0	3	0	5	0	4	1	2	2	3	1	2	1	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr9:125673155C>G	uc004bnh.2	-	2	1286	c.1197G>C	c.(1195-1197)AAG>AAC	p.K399N		NM_006626	NP_006617	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	399	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGTTAAGTGCTTTTTGAGAG	0.413													4	37					0	0	0	0	G	125673155	G	G	125673155	3	3	109	1	0	0	0	0	1	0	0	0	17619	796	28	4	81	4	ZBTB6	9	125673155	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	93041524	125673155	15540276	66	20195											
C9orf7	11094	broad.mit.edu	37	chr9	136333048	136333048	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctttccccccaggatggCggtcgttcccatcgtcatca	5	11	9	16	3	2	0	2	0	0	0	6	1	4	1	4	3	1	2	4	3	0	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr9:136333048C>T	uc011mdg.1	+	4	428	c.326C>T	c.(325-327)GCG>GTG	p.A109V	C9orf7_uc004cec.2_Missense_Mutation_p.A67V|C9orf7_uc011mdh.1_Missense_Mutation_p.A109V|C9orf7_uc011mdi.1_Missense_Mutation_p.A67V|C9orf7_uc010nan.2_RNA	NM_017586	NP_060056	Q9UGQ2	FLOWR_HUMAN	hypothetical protein LOC11094 isoform a	109	Helical; (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(294;5.7e-39)|all cancers(34;1.83e-23)|OV - Ovarian serous cystadenocarcinoma(145;8.94e-08)|Epithelial(140;1.01e-06)		CCCAGGATGGCGGTCGTTCCC	0.637													36	5					0	0	0	0	T	136333048	T	T	136333048	3	4	109	1	0	0	0	0	1	0	0	0	2505	768	27	1	340	1	C9orf7	9	136333048	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	10659893	136333048	4880383	67	20196											
UPF2	26019	broad.mit.edu	37	chr10	12001352	12001352	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgcttctttctcatcatttGctcctgaaataaaaagtcca	11	16	4	10	0	3	1	2	1	2	0	6	1	5	1	2	0	2	2	2	0	4	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr10:12001352G>T	uc001ila.2	-	11	2662	c.2188C>A	c.(2188-2190)CAA>AAA	p.Q730K	UPF2_uc001ilb.2_Missense_Mutation_p.Q730K|UPF2_uc001ilc.2_Missense_Mutation_p.Q730K|UPF2_uc009xiz.1_Missense_Mutation_p.Q730K	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	730	MIF4G 2.|Sufficient for interaction with UPF3A and UPF3B.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				CTCATCATTTGCTCCTGAAAT	0.363													9	27					3.09899e-07	5.4812e-07	1	0	T	12001352	T	T	12001352	3	4	109	1	0	0	0	0	1	0	0	0	17072	1328	46	4	1674	4	UPF2	10	12001352	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08		12001352	123533395	68	20197											
DHTKD1	55526	broad.mit.edu	37	chr10	12126710	12126710	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggagacgtttaccacagAagagcgaaaacatctgtcga	17	6	10	8	3	1	3	0	0	1	3	2	6	1	3	1	1	3	1	1	1	5	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr10:12126710A>C	uc001ild.3	+	3	581	c.482A>C	c.(481-483)GAA>GCA	p.E161A		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	161					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			TTTACCACAGAAGAGCGAAAA	0.353													45	92					0	0	0	0	C	12126710	C	C	12126710	3	2	109	1	0	0	0	0	1	0	0	0	4522	246	9	5	492	5	DHTKD1	10	12126710	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	125358	12126710	123408037	69	20198											
RET	5979	broad.mit.edu	37	chr10	43604571	43604571	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacttccagggcccaggaGcgggcgtcctcttgctccac	6	7	12	16	2	1	1	0	0	1	1	4	2	4	2	4	3	2	1	4	3	0	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr10:43604571G>A	uc001jal.2	+	6	1346	c.1156G>A	c.(1156-1158)GCG>ACG	p.A386T	RET_uc001jak.1_Missense_Mutation_p.A386T|RET_uc010qez.1_Missense_Mutation_p.A132T	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	386	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	GGGCCCAGGAGCGGGCGTCCT	0.632		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				20	23					0	0	0	0	A	43604571	A	A	43604571	3	1	109	1	0	0	0	0	1	0	0	0	13300	971	34	4	1178	4	RET	10	43604571	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	31477861	43604571	91930176	70	20199											
PCDH15	65217	broad.mit.edu	37	chr10	55849763	55849763	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtttctgaaagattaaaaaCtctctgaggatctccattct	12	14	6	9	1	4	3	0	2	4	1	6	4	4	4	1	1	1	1	1	1	4	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr10:55849763C>A	uc001jju.1	-	16	2373	c.1978G>T	c.(1978-1980)GTT>TTT	p.V660F	PCDH15_uc010qhq.1_Missense_Mutation_p.V665F|PCDH15_uc010qhr.1_Missense_Mutation_p.V660F|PCDH15_uc010qhs.1_Missense_Mutation_p.V672F|PCDH15_uc010qht.1_Missense_Mutation_p.V667F|PCDH15_uc010qhu.1_Missense_Mutation_p.V660F|PCDH15_uc001jjv.1_Missense_Mutation_p.V638F|PCDH15_uc010qhv.1_Missense_Mutation_p.V660F|PCDH15_uc010qhw.1_Missense_Mutation_p.V623F|PCDH15_uc010qhx.1_Intron|PCDH15_uc010qhy.1_Missense_Mutation_p.V665F|PCDH15_uc010qhz.1_Missense_Mutation_p.V660F|PCDH15_uc010qia.1_Missense_Mutation_p.V638F|PCDH15_uc010qib.1_Missense_Mutation_p.V638F|PCDH15_uc001jjw.2_Missense_Mutation_p.V660F	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	660	Cadherin 6.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AGATTAAAAACTCTCTGAGGA	0.338										HNSCC(58;0.16)			29	94					8.88839e-20	1.69925e-19	1	0	A	55849763	A	A	55849763	3	1	109	1	0	0	0	0	1	0	0	0	11565	565	20	4	5580	4	PCDH15	10	55849763	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	12245192	55849763	79684984	71	20200											
FAM22D	728130	broad.mit.edu	37	chr10	89118157	89118157	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccagacagcggtagtcagTgcccagcctgaggggatggc	8	6	16	11	1	1	2	1	1	0	1	1	3	1	3	3	4	4	1	3	4	1	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr10:89118157T>C	uc001kes.2	+	1	681	c.135T>C	c.(133-135)AGT>AGC	p.S45S	FAM22D_uc009xte.1_Silent_p.S45S	NM_001009610	NP_001009610	Q5VT03	FA22D_HUMAN	hypothetical protein LOC728130	45											0						CGGTAGTCAGTGCCCAGCCTG	0.512													17	443					0	0	0	0	C	89118157	C	C	89118157	2	2	109	1	0	0	0	0	0	0	0	1	5572	1693	59	5		5	FAM22D	10	89118157	Silent	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	33268394	89118157	46416590	72	20201											
DRD4	1815	broad.mit.edu	37	chr11	639780	639780	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcggcctcaacgacgtGcgcggccgcgaccccgccgt	4	5	14	18	9	1	0	1	0	0	0	1	2	1	0	5	2	3	0	5	2	1	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr11:639780G>A	uc001lqp.1	+	3	531	c.531G>A	c.(529-531)GTG>GTA	p.V177V		NM_000797	NP_000788	P21917	DRD4_HUMAN	dopamine receptor D4	177	Extracellular (Potential).				activation of MAPK activity|adult locomotory behavior|arachidonic acid secretion|behavioral fear response|behavioral response to cocaine|behavioral response to ethanol|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of protein secretion|positive regulation of sodium:hydrogen antiporter activity|regulation of dopamine metabolic process|regulation of inhibitory postsynaptic membrane potential|response to amphetamine|response to histamine|social behavior	integral to plasma membrane	dopamine D4 receptor activity|drug binding|potassium channel regulator activity|SH3 domain binding				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.36e-28)|Epithelial(43;2.59e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Apomorphine(DB00714)|Clozapine(DB00363)|Olanzapine(DB00334)|Pramipexole(DB00413)|Promazine(DB00420)|Propiomazine(DB00777)|Ropinirole(DB00268)|Thiethylperazine(DB00372)|Ziprasidone(DB00246)	TCAACGACGTGCGCGGCCGCG	0.726													7	7					0	0	0	0	A	639780	A	A	639780	2	1	109	1	0	0	0	0	0	0	0	1	4781	1306	46	4		4	DRD4	11	639780	Silent	SNP	G	TCGA-CQ-6228-01A-11D-1912-08		639780	134366736	73	20202											
OR51E2	81285	broad.mit.edu	37	chr11	4703785	4703785	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacatcggagcgtgcaggcTgcgttccgtccttacgatga	7	10	13	11	5	0	1	0	1	0	0	3	3	2	2	2	2	5	4	2	2	2	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr11:4703785T>C	uc001lzk.2	-	2	401	c.157A>G	c.(157-159)AGC>GGC	p.S53G		NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(3)|ovary(2)	5		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GCGTGCAGGCTGCGTTCCGTC	0.512													3	77					0	0	0	0	C	4703785	C	C	4703785	3	2	109	1	0	0	0	0	1	0	0	0	11149	1580	55	5	809	5	OR51E2	11	4703785	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	4064005	4703785	130302731	74	20203											
PTPRJ	5795	broad.mit.edu	37	chr11	48158579	48158579	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcaatgtgtccaacattgAtgtaagtaccaacaccacag	15	8	7	11	0	0	1	0	1	0	0	1	1	1	1	3	0	4	3	3	0	5	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr11:48158579A>C	uc001ngp.3	+	10	2253	c.1898A>C	c.(1897-1899)GAT>GCT	p.D633A	PTPRJ_uc010rhr.1_Missense_Mutation_p.D78A	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	633	Extracellular (Potential).|Fibronectin type-III 7.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						TCCAACATTGATGTAAGTACC	0.398													12	87					0	0	0	0	C	48158579	C	C	48158579	3	2	109	1	0	0	0	0	1	0	0	0	12869	333	12	5	1945	5	PTPRJ	11	48158579	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	43454794	48158579	86847937	75	20204											
MED17	9440	broad.mit.edu	37	chr11	93527025	93527025	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttagaggggtctgcatatAtcaaggtatttgtcaaaata	14	14	9	4	0	3	1	2	0	1	1	3	1	3	1	0	3	1	2	0	3	8	7			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr11:93527025A>G	uc001pem.3	+	4	1044	c.769A>G	c.(769-771)ATC>GTC	p.I257V		NM_004268	NP_004259	Q9NVC6	MED17_HUMAN	mediator complex subunit 17	257					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GTCTGCATATATCAAGGTATT	0.299													14	407					0	0	0	0	G	93527025	G	G	93527025	3	3	109	1	0	0	0	0	1	0	0	0	9488	449	16	5	783	5	MED17	11	93527025	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	45368446	93527025	41479491	76	20205											
TMPRSS13	84000	broad.mit.edu	37	chr11	117789522	117789522	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atgcctgggctggagatgctCcagctgaaggtgttcttgct	6	12	14	9	0	1	2	0	1	1	1	2	3	2	2	2	3	4	5	2	3	1	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr11:117789522C>G	uc001prs.1	-	2	146	c.53G>C	c.(52-54)GGA>GCA	p.G18A	TMPRSS13_uc009yzr.1_5'UTR|TMPRSS13_uc001prt.1_5'UTR|TMPRSS13_uc001pru.1_Missense_Mutation_p.G18A	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	18	4 X 5 AA repeats of T-P-P-G-R.|2-1; approximate.|12 X 5 AA repeats of A-S-P-A-[GLQR].|Cytoplasmic (Potential).|Ala-rich.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			pancreas(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		TGGAGATGCTCCAGCTGAAGG	0.617													13	24					0	0	0	0	G	117789522	G	G	117789522	3	3	109	1	0	0	0	0	1	0	0	0	16311	855	30	2	1698	2	TMPRSS13	11	117789522	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	24262497	117789522	17216994	77	20206											
ZNF384	171017	broad.mit.edu	37	chr12	6788350	6788350	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaacattgtgttctcgatCtaagagaaaaggaaggggac	15	9	12	5	1	2	2	0	1	2	1	3	6	2	4	0	3	1	1	0	3	5	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr12:6788350C>G	uc010sfh.1	-	4	275	c.67_splice	c.e4-1	p.I23_splice	ZNF384_uc001qpz.2_Splice_Site_p.I23_splice|ZNF384_uc001qqa.2_Splice_Site_p.I23_splice|ZNF384_uc001qqb.2_Splice_Site_p.I23_splice|ZNF384_uc001qqc.2_Splice_Site_p.I23_splice|ZNF384_uc001qqd.2_Splice_Site_p.I23_splice|ZNF384_uc001qqe.2_Splice_Site_p.I23_splice|ZNF384_uc009zew.1_5'Flank	NM_001135734	NP_001129206	Q8TF68	ZN384_HUMAN	nuclear matrix transcription factor 4 isoform d						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	haematopoietic_and_lymphoid_tissue(4)|central_nervous_system(3)|kidney(1)	8						TGTTCTCGATCTAAGAGAAAA	0.532			T	EWSR1|TAF15 	ALL								26	47					0	0	0	0	G	6788350	G	G	6788350	5	3	109	1	0	0	0	0	0	0	1	0	17942	927	32	2	1699	2	ZNF384	12	6788350	Splice_Site	SNP	C	TCGA-CQ-6228-01A-11D-1912-08		6788350	127063545	78	20207											
ALG10B	144245	broad.mit.edu	37	chr12	38712166	38712166	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtctgaacatgttgtctgctCcattgggatgctcagatttg	7	15	11	8	0	3	2	1	1	2	1	4	3	4	3	1	1	3	3	1	1	1	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr12:38712166C>T	uc001rln.3	+	2	414	c.275C>T	c.(274-276)TCC>TTC	p.S92F	ALG10B_uc001rlo.3_Missense_Mutation_p.S62F|ALG10B_uc010skk.1_Missense_Mutation_p.S32F	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	92	Cytoplasmic (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				GTTGTCTGCTCCATTGGGATG	0.418													7	98					0	0	0	0	T	38712166	T	T	38712166	3	4	109	1	0	0	0	0	1	0	0	0	512	855	30	2	281	2	ALG10B	12	38712166	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	31923816	38712166	95139729	79	20208			1	25		3	3	2597	C		5.453677e-05
ALG10B	144245	broad.mit.edu	37	chr12	38714315	38714315	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcagtttcttttggcttattCcatgtcctttaaaaacttga	9	19	5	8	0	2	1	1	1	1	0	4	1	4	1	2	1	1	2	2	1	4	8			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr12:38714315C>G	uc001rln.3	+	3	861	c.722C>G	c.(721-723)TCC>TGC	p.S241C	ALG10B_uc001rlo.3_Missense_Mutation_p.S211C|ALG10B_uc010skk.1_Missense_Mutation_p.S181C	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	241	Cytoplasmic (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TTGGCTTATTCCATGTCCTTT	0.368													9	114					0	0	0	0	G	38714315	G	G	38714315	3	3	109	1	0	0	0	0	1	0	0	0	512	855	30	2	732	2	ALG10B	12	38714315	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	2149	38714315	95137580	80	20209			1	25		3	3	2597	C		5.453677e-05
ALG10B	144245	broad.mit.edu	37	chr12	38714762	38714762	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatagctgactcattgaaatCaaagccaattttttggaatt	14	15	6	6	0	2	2	2	2	0	0	2	3	2	3	1	1	2	1	1	1	6	7			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr12:38714762C>G	uc001rln.3	+	3	1308	c.1169C>G	c.(1168-1170)TCA>TGA	p.S390*	ALG10B_uc001rlo.3_Nonsense_Mutation_p.S360*|ALG10B_uc010skk.1_Nonsense_Mutation_p.S330*	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	390	Cytoplasmic (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TCATTGAAATCAAAGCCAATT	0.313													6	59					0	0	0	0	G	38714762	G	G	38714762	4	3	109	1	0	0	0	0	0	1	0	0	512	838	29	2	1179	2	ALG10B	12	38714762	Nonsense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	447	38714762	95137133	81	20210			1	25		3	3	2597	C		5.453677e-05
NAV3	89795	broad.mit.edu	37	chr12	78513391	78513391	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccctacaatatcgcagcttgCcccgcccttcaaaatccagc	10	8	5	18	2	1	0	1	0	0	0	3	0	2	0	5	0	4	2	5	0	5	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr12:78513391C>A	uc001syp.2	+	15	3588	c.3415C>A	c.(3415-3417)CCC>ACC	p.P1139T	NAV3_uc001syo.2_Missense_Mutation_p.P1139T|NAV3_uc010sub.1_Missense_Mutation_p.P639T|NAV3_uc009zsf.2_Missense_Mutation_p.P147T	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1139	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCGCAGCTTGCCCCGCCCTTC	0.512										HNSCC(70;0.22)			23	51					3.01185e-09	5.43806e-09	1	0	A	78513391	A	A	78513391	3	1	109	1	0	0	0	0	1	0	0	0	10238	739	26	4	3473	4	NAV3	12	78513391	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	39798629	78513391	55338504	82	20211											
NR2C1	7181	broad.mit.edu	37	chr12	95442958	95442958	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atgcccgctactgagctctgGcaggctgtgctctctccagg	5	10	12	14	1	2	1	0	1	2	0	4	1	3	1	2	3	4	5	2	3	1	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr12:95442958G>A	uc001tdm.3	-	9	1273	c.1017C>T	c.(1015-1017)TGC>TGT	p.C339C	NR2C1_uc010suu.1_Silent_p.C339C|NR2C1_uc001tdo.3_Silent_p.C339C|NR2C1_uc001tdn.3_Silent_p.C339C	NM_003297	NP_003288	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	339					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1						CTGAGCTCTGGCAGGCTGTGC	0.468													44	78					0	0	0	0	A	95442958	A	A	95442958	2	1	109	1	0	0	0	0	0	0	0	1	10676	1195	42	4		4	NR2C1	12	95442958	Silent	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	16929567	95442958	38408937	83	20212											
NEDD1	121441	broad.mit.edu	37	chr12	97337517	97337517	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaatatatatgggaaaacagGaatctaaagactccttcaaa	20	9	6	6	0	2	1	1	0	1	1	3	3	3	3	1	2	1	0	1	2	10	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr12:97337517G>T	uc001teu.3	+	12	1813	c.1474G>T	c.(1474-1476)GAA>TAA	p.E492*	NEDD1_uc001tev.3_Nonsense_Mutation_p.E492*|NEDD1_uc010svc.1_Nonsense_Mutation_p.E403*|NEDD1_uc001tew.2_Nonsense_Mutation_p.E499*|NEDD1_uc001tex.2_Nonsense_Mutation_p.E403*	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	492					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						GGGAAAACAGGAATCTAAAGA	0.383													12	22					7.03913e-09	1.26219e-08	1	0	T	97337517	T	T	97337517	4	4	109	1	0	0	0	0	0	1	0	0	10363	1175	41	2	1537	2	NEDD1	12	97337517	Nonsense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	1894559	97337517	36514378	84	20213											
EDNRB	1910	broad.mit.edu	37	chr13	78493512	78493512	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatcaatgattttaattcaaCaccaagcccgaatgtttacc	15	12	4	10	1	2	1	2	1	0	0	2	2	2	1	3	0	3	1	3	0	7	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr13:78493512C>T	uc001vko.2	-						uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Intron|EDNRB_uc010aez.1_5'Flank|EDNRB_uc001vkp.1_Intron|EDNRB_uc010afa.1_5'UTR	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor						activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	TTTAATTCAACACCAAGCCCG	0.458											OREG0022452	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	28					0	0	0	0	T	78493512	T	T	78493512	1	4	109	0	1	0	0	0	0	0	0	0	4942	493	17	4		4	EDNRB	13	78493512	5'Flank	SNP	C	TCGA-CQ-6228-01A-11D-1912-08		78493512	36676366	85	20214											
CATSPER2	117155	broad.mit.edu	37	chr15	43939610	43939610	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacgctgaggctttatagaGaaacgcactagctggtgttg	11	11	12	7	2	0	2	0	1	0	1	0	3	0	2	0	2	3	5	0	2	5	6			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr15:43939610G>C	uc001zsh.2	-	3	416	c.201C>G	c.(199-201)TTC>TTG	p.F67L	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Missense_Mutation_p.F67L|CATSPER2_uc001zsj.2_Missense_Mutation_p.F67L|CATSPER2_uc001zsk.2_Missense_Mutation_p.F67L|CATSPER2_uc001zsl.1_RNA	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	67	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GCTTTATAGAGAAACGCACTA	0.443													52	59					0	0	0	0	C	43939610	C	C	43939610	3	2	109	1	0	0	0	0	1	0	0	0	2700	933	33	2	1474	2	CATSPER2	15	43939610	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08		43939610	58591782	86	20215											
UNC13C	440279	broad.mit.edu	37	chr15	54305533	54305533	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaaaaccaggcacaatcaAcacacacaatgccagttaga	19	4	6	12	0	1	2	1	0	0	2	1	2	1	2	2	1	3	2	2	1	6	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr15:54305533A>G	uc002ack.2	+	1	433	c.433A>G	c.(433-435)ACA>GCA	p.T145A		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	145					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGCACAATCAACACACACAAT	0.458													4	87					0	0	0	0	G	54305533	G	G	54305533	3	3	109	1	0	0	0	0	1	0	0	0	17054	43	2	5	435	5	UNC13C	15	54305533	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	10365923	54305533	48225859	87	20216											
PIGB	9488	broad.mit.edu	37	chr15	55626120	55626120	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taattcgtcccacagctgtcAttctgtggacacctttgctc	7	14	7	13	1	2	0	1	0	1	0	5	1	3	1	2	1	2	2	2	1	1	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr15:55626120A>C	uc002act.2	+	6	1025	c.709A>C	c.(709-711)ATT>CTT	p.I237L	PIGB_uc010ugg.1_Missense_Mutation_p.I42L	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	237	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		CACAGCTGTCATTCTGTGGAC	0.398													7	43					0	0	0	0	C	55626120	C	C	55626120	3	2	109	1	0	0	0	0	1	0	0	0	11940	217	8	5	731	5	PIGB	15	55626120	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	1320587	55626120	46905272	88	20217											
AP3B2	8120	broad.mit.edu	37	chr15	83349371	83349371	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgttgcgcagcagcagcCggtggtcggggtccatgaca	6	8	17	10	3	0	1	0	1	0	0	2	1	1	1	2	5	4	4	2	5	0	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr15:83349371C>T	uc010uoh.1	-	8	1085	c.908G>A	c.(907-909)CGG>CAG	p.R303Q	AP3B2_uc010uoi.1_Missense_Mutation_p.R303Q|AP3B2_uc010uoj.1_Missense_Mutation_p.R271Q|AP3B2_uc010uog.1_5'Flank	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	303					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			CAGCAGCAGCCGGTGGTCGGG	0.706													4	29					0	0	0	0	T	83349371	T	T	83349371	3	4	109	1	0	0	0	0	1	0	0	0	745	652	23	1	2340	1	AP3B2	15	83349371	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	27723251	83349371	19182021	89	20218											
TM6SF1	53346	broad.mit.edu	37	chr15	83796130	83796130	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgctggcatatatgttctaTtctgttccttactttgtgac	7	19	7	8	0	2	1	0	1	2	0	3	1	3	1	1	1	2	4	1	1	4	8			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr15:83796130T>C	uc002bjp.2	+	9	931	c.822T>C	c.(820-822)TAT>TAC	p.Y274Y	TM6SF1_uc010bmq.2_Silent_p.Y243Y|TM6SF1_uc002bjq.2_Missense_Mutation_p.F168L|TM6SF1_uc010bmr.2_RNA|TM6SF1_uc002bjr.2_Silent_p.Y126Y	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	274	Helical; (Potential).					integral to membrane				ovary(1)	1						ATATGTTCTATTCTGTTCCTT	0.408													132	113					0	0	0	0	C	83796130	C	C	83796130	2	2	109	1	0	0	0	0	0	0	0	1	16038	1500	52	5		5	TM6SF1	15	83796130	Silent	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	446759	83796130	18735262	90	20219											
ZNF592	9640	broad.mit.edu	37	chr15	85333936	85333936	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttggtgttctttcctagAcctgccaggtatgccaaatg	7	15	9	10	0	2	1	0	0	2	1	3	1	3	1	4	2	2	2	4	2	3	6			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr15:85333936A>G	uc002bld.2	+	5	2557	c.2221A>G	c.(2221-2223)ACC>GCC	p.T741A	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	741	C2H2-type 4.				cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCTTTCCTAGACCTGCCAGGT	0.552													29	64					0	0	0	0	G	85333936	G	G	85333936	3	3	109	1	0	0	0	0	1	0	0	0	18089	289	10	5	2227	5	ZNF592	15	85333936	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	1537806	85333936	17197456	91	20220											
DNAH3	55567	broad.mit.edu	37	chr16	20944608	20944608	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagggttcctctgcgggcActtgttttgtagactggaca	7	12	14	8	1	1	2	0	0	1	2	2	4	2	3	1	3	1	4	1	3	1	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr16:20944608A>T	uc010vbe.1	-	62	12219	c.12219T>A	c.(12217-12219)AGT>AGA	p.S4073R	DNAH3_uc010vbd.1_Missense_Mutation_p.S1508R	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	4073					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTCTGCGGGCACTTGTTTTGT	0.512													58	104					0	0	0	0	T	20944608	T	T	20944608	3	4	109	1	0	0	0	0	1	0	0	0	4625	156	6	5	134	5	DNAH3	16	20944608	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08		20944608	69410145	92	20221											
GGA2	23062	broad.mit.edu	37	chr16	23480233	23480233	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggattgtcaagcagcagcaTctgagatatcacagctggag	12	9	12	8	0	3	1	2	1	1	1	3	4	3	3	0	2	4	4	0	2	2	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr16:23480233T>C	uc002dlq.2	-	16	1781	c.1705A>G	c.(1705-1707)ATG>GTG	p.M569V		NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	569	GAE.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		AGCAGCAGCATCTGAGATATC	0.512													29	39					0	0	0	0	C	23480233	C	C	23480233	3	2	109	1	0	0	0	0	1	0	0	0	6390	1435	50	5	144	5	GGA2	16	23480233	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	2535625	23480233	66874520	93	20222											
KIF22	3835	broad.mit.edu	37	chr16	29814096	29814096	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttttctgctcagccccctAcagaagctaagcagcatgga	10	10	8	13	0	2	1	1	0	1	1	2	2	2	2	2	1	6	4	2	1	3	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr16:29814096A>G	uc002dts.3	+	9	1311	c.1287A>G	c.(1285-1287)CTA>CTG	p.L429L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KIF22_uc010vdv.1_Silent_p.L361L|KIF22_uc010vdw.1_Silent_p.L361L|KIF22_uc010bzf.2_Silent_p.L361L|KIF22_uc002dtt.1_5'Flank|KIF22_uc002frc.1_5'Flank	NM_007317	NP_015556	Q14807	KIF22_HUMAN	kinesin family member 22	429				APASASQKLSPLQKLSSMDPAMLERLLSLDRLLASQGSQ -> SSSLCLPETQPPTEAKAAWTRPCGAPPQLGPSACLPGE P (in Ref. 2; BAA33063).	blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding				0						TCAGCCCCCTACAGAAGCTAA	0.592													3	93					0	0	0	0	G	29814096	G	G	29814096	2	3	109	1	0	0	0	0	0	0	0	1	8329	378	14	5		5	KIF22	16	29814096	Silent	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	6333863	29814096	60540657	94	20223											
ASPHD1	253982	broad.mit.edu	37	chr16	29913176	29913176	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgccggcttttccgttcTcctgcctggggcccggctcg	2	11	12	16	4	1	0	0	0	1	0	4	0	2	0	5	4	2	3	5	4	1	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr16:29913176T>C	uc002dut.2	+	1	1030	c.884T>C	c.(883-885)CTC>CCC	p.L295P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_5'Flank|SEZ6L2_uc002dur.3_5'Flank|SEZ6L2_uc002duq.3_5'Flank|SEZ6L2_uc002dus.3_5'Flank|SEZ6L2_uc010vec.1_5'Flank|SEZ6L2_uc010ved.1_5'Flank|ASPHD1_uc002duu.3_RNA|ASPHD1_uc010bzi.2_RNA	NM_181718	NP_859069	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	295	Lumenal (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity				0						TTTTCCGTTCTCCTGCCTGGG	0.657													14	16					0	0	0	0	C	29913176	C	C	29913176	3	2	109	1	0	0	0	0	1	0	0	0	1056	1551	54	5	886	5	ASPHD1	16	29913176	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	99080	29913176	60441577	95	20224											
ZNF646	9726	broad.mit.edu	37	chr16	31089215	31089215	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctcgccgaagtgcagacAtcggggctgagggtgccccc	6	6	15	14	3	0	2	0	1	0	1	2	3	0	2	3	3	3	3	3	3	1	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr16:31089215A>T	uc002eap.2	+	2	1859	c.1570A>T	c.(1570-1572)ATC>TTC	p.I524F		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						AAGTGCAGACATCGGGGCTGA	0.622													10	16					0	0	0	0	T	31089215	T	T	31089215	3	4	109	1	0	0	0	0	1	0	0	0	18129	217	8	5	1572	5	ZNF646	16	31089215	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	1176039	31089215	59265538	96	20225											
SNX20	124460	broad.mit.edu	37	chr16	50707787	50707787	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggcccaggtactcctgcaGggcgcgccgacgctcacaga	8	4	13	16	4	1	1	1	0	0	1	2	2	2	1	3	3	2	3	3	3	1	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr16:50707787G>A	uc002egk.2	-	4	654	c.481C>T	c.(481-483)CTG>TTG	p.L161L	SNX20_uc010vgp.1_Intron|SNX20_uc002egi.3_Intron	NM_182854	NP_878274	Q7Z614	SNX20_HUMAN	sorting nexin 20 isoform 1	161	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			ovary(1)	1						TACTCCTGCAGGGCGCGCCGA	0.647													5	25					0	0	0	0	A	50707787	A	A	50707787	2	1	109	1	0	0	0	0	0	0	0	1	14956	991	35	4		4	SNX20	16	50707787	Silent	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	19618572	50707787	39646966	97	20226											
CTCF	10664	broad.mit.edu	37	chr16	67670700	67670700	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccagccccaccacccgccAagaagcggagaggacgaccc	11	0	10	20	3	0	2	0	0	0	2	0	5	0	3	8	2	2	0	8	2	2	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr16:67670700A>T	uc002etl.2	+	11	2235	c.1945A>T	c.(1945-1947)AAG>TAG	p.K649*	CTCF_uc010cek.2_Nonsense_Mutation_p.K321*|CTCF_uc002etm.1_Nonsense_Mutation_p.K138*	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	649					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		ACCACCCGCCAAGAAGCGGAG	0.587													79	135					0	0	0	0	T	67670700	T	T	67670700	4	4	109	1	0	0	0	0	0	1	0	0	4017	131	5	5	1979	5	CTCF	16	67670700	Nonsense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	16962913	67670700	22684053	98	20227											
TSNAXIP1	55815	broad.mit.edu	37	chr16	67861219	67861219	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggagctgatggaggcagggGgctggcatcccagcagcagc	9	4	18	10	0	0	1	0	1	0	0	1	3	1	3	1	6	4	6	1	6	0	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr16:67861219G>A	uc002euj.2	+	14	1964	c.1570G>A	c.(1570-1572)GGC>AGC	p.G524S	TSNAXIP1_uc010vjz.1_Missense_Mutation_p.G401S|TSNAXIP1_uc002euf.3_Missense_Mutation_p.G257S|TSNAXIP1_uc010vka.1_Missense_Mutation_p.G578S|TSNAXIP1_uc010vkb.1_Missense_Mutation_p.G509S|TSNAXIP1_uc002eug.3_Missense_Mutation_p.G232S|TSNAXIP1_uc002euh.3_Missense_Mutation_p.G232S|TSNAXIP1_uc002eui.3_Missense_Mutation_p.G232S|TSNAXIP1_uc002euk.2_Missense_Mutation_p.G257S	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	524					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		GGAGGCAGGGGGCTGGCATCC	0.597													32	36					0	0	0	0	A	67861219	A	A	67861219	3	1	109	1	0	0	0	0	1	0	0	0	16699	1232	43	4	1616	4	TSNAXIP1	16	67861219	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	190519	67861219	22493534	99	20228											
TP53	7157	broad.mit.edu	37	chr17	7579386	7579386	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagctgccctggtaggtttTctgggaagggacagaagatg	9	10	16	6	0	1	2	0	0	1	2	1	4	1	4	1	4	2	4	1	4	4	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr17:7579386T>A	uc002gim.2	-	4	495	c.301A>T	c.(301-303)AAA>TAA	p.K101*	TP53_uc002gig.1_Nonsense_Mutation_p.K101*|TP53_uc002gih.2_Nonsense_Mutation_p.K101*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.K101*|TP53_uc010cni.1_Nonsense_Mutation_p.K101*|TP53_uc002gij.2_Nonsense_Mutation_p.K101*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.K62*|TP53_uc010cnk.1_Nonsense_Mutation_p.K116*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	101	Interaction with HIPK1 (By similarity).|Interaction with WWOX.		K -> R (in sporadic cancers; somatic mutation).|K -> N (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.K101R(3)|p.G59fs*23(3)|p.T102fs*21(2)|p.V73fs*9(1)|p.K101fs*48(1)|p.K101N(1)|p.W91fs*13(1)|p.K101*(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGTAGGTTTTCTGGGAAGGG	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			33	8					0	0	0	0	A	7579386	A	A	7579386	4	1	109	1	0	0	0	0	0	1	0	0	16448	1792	62	5	1001	5	TP53	17	7579386	Nonsense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08		7579386	73615824	100	20229											
SEZ6	124925	broad.mit.edu	37	chr17	27308731	27308731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggggctgagtgggtaccgCagccatggctggagtggggc	5	7	20	9	1	0	1	0	1	0	0	0	2	0	2	2	7	2	4	2	7	1	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr17:27308731C>T	uc002hdp.2	-	2	576	c.382G>A	c.(382-384)GCG>ACG	p.A128T	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.A128T|SEZ6_uc002hdq.1_Missense_Mutation_p.A3T|SEZ6_uc010crz.1_Missense_Mutation_p.A128T	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	128	Pro-rich.|Extracellular (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			GTGGGTACCGCAGCCATGGCT	0.652													13	21					0	0	0	0	T	27308731	T	T	27308731	3	4	109	1	0	0	0	0	1	0	0	0	14207	710	25	4	2679	4	SEZ6	17	27308731	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	19729345	27308731	53886479	101	20230											
RFFL	117584	broad.mit.edu	37	chr17	33343508	33343508	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagatctctttcagctgcCgcactgtcaggccttcaatg	8	11	8	14	1	4	1	3	0	1	1	5	1	4	1	3	1	2	2	3	1	2	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr17:33343508C>T	uc002hin.1	-	5	940	c.767G>A	c.(766-768)CGG>CAG	p.R256Q	RFFL_uc002hiq.2_Missense_Mutation_p.R173Q|RFFL_uc002him.1_Missense_Mutation_p.R256Q|RFFL_uc010cti.1_Missense_Mutation_p.R262Q|RFFL_uc002hip.1_Missense_Mutation_p.R228Q|RFFL_uc002hio.1_Missense_Mutation_p.R256Q	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	256	SAP 2.				apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TTTCAGCTGCCGCACTGTCAG	0.537													10	163					0	0	0	0	T	33343508	T	T	33343508	3	4	109	1	0	0	0	0	1	0	0	0	13315	652	23	1	336	1	RFFL	17	33343508	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	6034777	33343508	47851702	102	20231											
DUSP14	11072	broad.mit.edu	37	chr17	35872374	35872375	+	Translation_Start_Site	INS	-	A	A																															gtgtgactgctggcgtcttcINSatgagctccagaggtcacag																										TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr17:35872374_35872375insA	uc002hnx.2	+	3					DUSP14_uc002hny.2_Translation_Start_Site|DUSP14_uc002hnz.2_Translation_Start_Site	NM_007026	NP_008957	O95147	DUS14_HUMAN	dual specificity phosphatase 14								MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Breast(25;0.00637)|Ovarian(249;0.15)				CTGGCGTCTTCATGAGCTCCAG	0.505													---	---	---								A	35872375	A	A	35872374	6	5	109	1	0	1	1	0	0	0	0	0	4836	841	29	0		0	DUSP14	17	35872374	Translation_Start_Site	INS	-	TCGA-CQ-6228-01A-11D-1912-08	2528866	35872374	45322836	103	20232											
KRT26	353288	broad.mit.edu	37	chr17	38926053	38926053	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccagggtttgcagattgcGttttaattcggtcagctcat	7	16	10	8	2	2	1	2	0	0	1	4	1	3	1	1	2	3	4	1	2	1	6			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr17:38926053G>A	uc002hvf.2	-	5	968	c.922C>T	c.(922-924)CGC>TGC	p.R308C		NM_181539	NP_853517	Q7Z3Y9	K1C26_HUMAN	keratin 26	308	Rod.|Coil 2.					intermediate filament	structural molecule activity				0		Breast(137;0.00526)				TGCAGATTGCGTTTTAATTCG	0.438													45	20					0	0	0	0	A	38926053	A	A	38926053	3	1	109	1	0	0	0	0	1	0	0	0	8502	1145	40	1	500	1	KRT26	17	38926053	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	3053679	38926053	42269157	104	20233											
H3F3B	3021	broad.mit.edu	37	chr17	73775146	73775146	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctgtagcgatgaggcttcTtcaccccgccggtagaggga	8	8	13	12	3	2	2	1	1	1	1	2	4	2	3	4	3	1	3	4	3	2	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr17:73775146T>A	uc002jpl.2	-	2	243	c.110A>T	c.(109-111)AAG>ATG	p.K37M		NM_005324	NP_005315	P84243	H33_HUMAN	H3 histone, family 3B	37					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			ovary(1)	1	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			ATGAGGCTTCTTCACCCCGCC	0.662											OREG0024740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	19					0	0	0	0	A	73775146	A	A	73775146	3	1	109	1	0	0	0	0	1	0	0	0	6973	1609	56	5	312	5	H3F3B	17	73775146	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	34849093	73775146	7420064	105	20234											
ANGPTL6	83854	broad.mit.edu	37	chr19	10204170	10204170	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agggagaagccatcatagtgGgcacgtgctccacggccccc	9	5	13	14	2	1	1	1	0	0	1	2	2	2	1	4	3	2	2	4	3	2	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr19:10204170G>A	uc002mmx.1	-	5	1195	c.1077C>T	c.(1075-1077)GCC>GCT	p.A359A	ANGPTL6_uc002mmy.1_Silent_p.A359A	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	359	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			CATCATAGTGGGCACGTGCTC	0.612													15	31					0	0	0	0	A	10204170	A	A	10204170	2	1	109	1	0	0	0	0	0	0	0	1	618	1219	43	4		4	ANGPTL6	19	10204170	Silent	SNP	G	TCGA-CQ-6228-01A-11D-1912-08		10204170	48924813	106	20235											
CCDC105	126402	broad.mit.edu	37	chr19	15132682	15132682	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagacccctggttcgcatgtAccagagacacgtgggcaccc	9	6	11	15	2	0	2	0	0	0	2	1	3	0	2	4	2	1	4	4	2	1	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr19:15132682A>G	uc002nae.2	+	6	1301	c.1202A>G	c.(1201-1203)TAC>TGC	p.Y401C		NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	401					microtubule cytoskeleton organization	microtubule				ovary(1)	1						GTTCGCATGTACCAGAGACAC	0.632													15	34					0	0	0	0	G	15132682	G	G	15132682	3	3	109	1	0	0	0	0	1	0	0	0	2752	391	14	5	1224	5	CCDC105	19	15132682	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	4928512	15132682	43996301	107	20236											
C19orf50	79036	broad.mit.edu	37	chr19	18675832	18675832	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcatcttccgccgtatcagGtgggtgctcagtgccacccc	6	9	11	15	2	3	0	2	0	1	0	4	0	4	0	5	2	3	3	5	2	1	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr19:18675832G>A	uc002njo.2	+	3	396	c.254_splice	c.e3+1	p.R85_splice	C19orf50_uc002njp.2_Splice_Site|C19orf50_uc002njq.2_Splice_Site_p.R85_splice	NM_024069	NP_076974	Q9BQD3	CS050_HUMAN	hypothetical protein LOC79036								protein binding				0						GCCGTATCAGGTGGGTGCTCA	0.587													32	44					0	0	0	0	A	18675832	A	A	18675832	5	1	109	1	0	0	0	0	0	0	1	0	1941	1275	44	4	261	4	C19orf50	19	18675832	Splice_Site	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	3543150	18675832	40453151	108	20237											
NUDT19	390916	broad.mit.edu	37	chr19	33200149	33200149	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaaagaaatttggttgccacCcccacagttctacgaagtga	14	9	8	10	1	1	2	0	1	1	1	1	3	1	2	3	1	2	2	3	1	5	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr19:33200149C>G	uc010edf.2	+	2	773	c.773C>G	c.(772-774)CCC>CGC	p.P258R		NM_001105570	NP_001099040	A8MXV4	NUD19_HUMAN	nudix (nucleoside diphosphate linked moiety	258	Nudix hydrolase.					mitochondrion|peroxisome	hydrolase activity|metal ion binding				0	Esophageal squamous(110;0.137)					TGGTTGCCACCCCCACAGTTC	0.433													29	229					0	0	0	0	G	33200149	G	G	33200149	3	3	109	1	0	0	0	0	1	0	0	0	10790	623	22	4	779	4	NUDT19	19	33200149	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	14524317	33200149	25928834	109	20238											
DKKL1	27120	broad.mit.edu	37	chr19	49867878	49867878	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcggcatctgctggtccTgctgctgctcctctctaccc	4	11	10	16	1	2	0	0	0	2	0	5	0	4	0	3	3	5	5	3	3	2	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr19:49867878T>C	uc002pnk.2	+	2	264	c.50T>C	c.(49-51)CTG>CCG	p.L17P	TEAD2_uc002pni.2_5'Flank|TEAD2_uc002pnj.2_5'Flank|TEAD2_uc010yao.1_5'Flank|TEAD2_uc010emw.2_5'Flank	NM_014419	NP_055234	Q9UK85	DKKL1_HUMAN	dickkopf-like 1 precursor	17					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity				0		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		CTGCTGGTCCTGCTGCTGCTC	0.677													3	55					0	0	0	0	C	49867878	C	C	49867878	3	2	109	1	0	0	0	0	1	0	0	0	4570	1580	55	5	56	5	DKKL1	19	49867878	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	16667729	49867878	9261105	110	20239											
TBC1D20	128637	broad.mit.edu	37	chr20	428589	428589	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggagcttgggccacacttttCgtctgatctcatcagtcagg	7	12	11	11	1	4	1	3	1	2	0	6	2	4	2	1	3	1	1	1	3	0	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr20:428589C>T	uc002wds.2	-	2	338	c.200G>A	c.(199-201)CGA>CAA	p.R67Q	TBC1D20_uc002wdv.2_5'UTR|TBC1D20_uc002wdt.2_RNA|TBC1D20_uc002wdu.2_RNA	NM_144628	NP_653229	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	67	Rab-GAP TBC.				interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)	1		all_epithelial(17;0.228)|Breast(17;0.231)				CCACACTTTTCGTCTGATCTC	0.537													8	60					0	0	0	0	T	428589	T	T	428589	3	4	109	1	0	0	0	0	1	0	0	0	15675	884	31	1	1039	1	TBC1D20	20	428589	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08		428589	62596931	111	20240											
PAX1	5075	broad.mit.edu	37	chr20	21695341	21695341	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagtgccggcccgcggggtgCacgcccagccagcccccagg	5	2	15	19	4	0	0	0	0	0	0	0	0	0	0	6	4	4	1	6	4	0	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr20:21695341C>T	uc002wsj.2	+	5	1559	c.1505C>T	c.(1504-1506)GCA>GTA	p.A502V	PAX1_uc010zsl.1_3'UTR|PAX1_uc010zsm.1_3'UTR	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	502					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						CCGCGGGGTGCACGCCCAGCC	0.687													13	24					0	0	0	0	T	21695341	T	T	21695341	3	4	109	1	0	0	0	0	1	0	0	0	11532	710	25	4	1523	4	PAX1	20	21695341	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	21266752	21695341	41330179	112	20241											
RALGAPB	57148	broad.mit.edu	37	chr20	37199442	37199442	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctcagagctgatgacagAgatcagtactggtgtggaaa	12	9	12	8	0	2	4	2	2	1	2	3	6	2	5	1	2	2	2	1	2	2	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr20:37199442A>T	uc002xiw.2	+	28	4351	c.4094A>T	c.(4093-4095)GAG>GTG	p.E1365V	RALGAPB_uc002xix.2_Missense_Mutation_p.E1362V|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Missense_Mutation_p.E1144V	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1365	Rap-GAP.				activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						CTGATGACAGAGATCAGTACT	0.358													22	29					0	0	0	0	T	37199442	T	T	37199442	3	4	109	1	0	0	0	0	1	0	0	0	13080	304	11	5	4200	5	RALGAPB	20	37199442	Missense_Mutation	SNP	A	TCGA-CQ-6228-01A-11D-1912-08	15504101	37199442	25826078	113	20242											
GRIK1	2897	broad.mit.edu	37	chr21	30934039	30934039	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcacatactcaatgctggtGgactccatcagcagcgcgta	10	9	10	12	2	3	0	3	0	0	0	4	1	4	1	1	2	4	3	1	2	3	2			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr21:30934039G>T	uc002yno.1	-	15	2726	c.2262C>A	c.(2260-2262)TCC>TCA	p.S754S	GRIK1_uc002ynn.2_Silent_p.S739S|GRIK1_uc011acs.1_Silent_p.S754S|GRIK1_uc011act.1_Silent_p.S615S	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	754	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CAATGCTGGTGGACTCCATCA	0.542													19	36					2.39187e-15	4.47401e-15	1	0	T	30934039	T	T	30934039	2	4	109	1	0	0	0	0	0	0	0	1	6812	1335	47	4		4	GRIK1	21	30934039	Silent	SNP	G	TCGA-CQ-6228-01A-11D-1912-08		30934039	17195856	114	20243											
HUNK	30811	broad.mit.edu	37	chr21	33296871	33296871	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtcagatccagcagatgaTccgccaccccaatatcactc	11	7	8	15	1	2	3	2	1	0	2	5	3	4	3	5	1	1	1	5	1	2	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr21:33296871T>C	uc002yph.2	+	2	713	c.353T>C	c.(352-354)ATC>ACC	p.I118T		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	118	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						CAGCAGATGATCCGCCACCCC	0.493													21	23					0	0	0	0	C	33296871	C	C	33296871	3	2	109	1	0	0	0	0	1	0	0	0	7497	1435	50	5	359	5	HUNK	21	33296871	Missense_Mutation	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	2362832	33296871	14833024	115	20244											
TCP10L	140290	broad.mit.edu	37	chr21	33951084	33951084	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttgtggccagcgtatttggGtattgtctcttcatcagctg	5	16	11	9	1	3	0	2	0	1	0	4	0	3	0	1	2	2	3	1	2	2	6			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr21:33951084G>A	uc002ypw.3	-	4	534	c.418C>T	c.(418-420)CCC>TCC	p.P140S		NM_144659	NP_653260	Q9NV44	CU077_HUMAN	T-complex 10A-2	Error:Variant_position_missing_in_Q9NV44_after_alignment											0						GCGTATTTGGGTATTGTCTCT	0.433													56	64					0	0	0	0	A	33951084	A	A	33951084	3	1	109	1	0	0	0	0	1	0	0	0	15777	1261	44	4	237	4	TCP10L	21	33951084	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	654213	33951084	14178811	116	20245											
MORC3	23515	broad.mit.edu	37	chr21	37736544	37736544	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagttccacctcagtctgaaCctgagagcaacaggtcagtg	12	8	10	11	0	3	2	2	2	1	1	4	3	4	2	3	1	3	2	3	1	3	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr21:37736544C>G	uc002yvi.2	+	14	1682	c.1606C>G	c.(1606-1608)CCT>GCT	p.P536A		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	536					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						TCAGTCTGAACCTGAGAGCAA	0.398													12	28					0	0	0	0	G	37736544	G	G	37736544	3	3	109	1	0	0	0	0	1	0	0	0	9756	507	18	4	1660	4	MORC3	21	37736544	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08	3785460	37736544	10393351	117	20246											
TMPRSS3	64699	broad.mit.edu	37	chr21	43795867	43795873	+	Frame_Shift_Del	DEL	GGTGTAC	-	-																															tccaggaaggaggtgacacgGgtgtacaccccaggcttgtt																										TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr21:43795867_43795873delGGTGTAC	uc002zbb.2	-	12	1500_1506	c.1299_1305delGTACACC	c.(1297-1305)GTGTACACCfs	p.V433fs	TMPRSS3_uc002zay.2_Frame_Shift_Del_p.V190fs|TMPRSS3_uc002zaz.2_Frame_Shift_Del_p.V306fs|TMPRSS3_uc002zba.2_Frame_Shift_Del_p.V306fs|TMPRSS3_uc002zbc.2_Frame_Shift_Del_p.V432fs	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	433_435	Peptidase S1.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						AGGTGACACGGGTGTACACCCCAGGCT	0.628													---	---	---								-	43795873	-	-	43795867	7	5	109	1	0	1	0	1	0	0	0	0	16314	1219	43	0	67	0	TMPRSS3	21	43795867	Frame_Shift_Del	DEL	GGTGTAC	TCGA-CQ-6228-01A-11D-1912-08	6059323	43795867	4334028	118	20247											
CLTCL1	8218	broad.mit.edu	37	chr22	19209568	19209568	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aatcacttcctcagaacaatCcacatcaagcagccctccaa	15	7	3	16	0	3	1	3	0	0	1	6	1	6	1	4	0	3	1	4	0	5	1			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chr22:19209568C>G	uc002zpb.2	-	16	2542	c.2467G>C	c.(2467-2469)GAT>CAT	p.D823H	CLTCL1_uc011agv.1_Missense_Mutation_p.D823H|CLTCL1_uc011agw.1_Missense_Mutation_p.D823H	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	823	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TCAGAACAATCCACATCAAGC	0.443			T	?	ALCL								43	84					0	0	0	0	G	19209568	G	G	19209568	3	3	109	1	0	0	0	0	1	0	0	0	3582	855	30	2	2523	2	CLTCL1	22	19209568	Missense_Mutation	SNP	C	TCGA-CQ-6228-01A-11D-1912-08		19209568	32094998	119	20248											
NR0B1	190	broad.mit.edu	37	chrX	30326947	30326947	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctttaccccctggcctctgCgcgaagtaggagcggtccca	6	9	11	15	3	2	0	0	0	2	0	3	2	3	1	4	3	3	1	4	3	3	3			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chrX:30326947C>T	uc004dcf.3	-	1	549	c.534G>A	c.(532-534)GCG>GCA	p.A178A		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	178	4 X 67 AA tandem repeats.|3.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	CTGGCCTCTGCGCGAAGTAGG	0.677											OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	9					0	0	0	0	T	30326947	T	T	30326947	2	4	109	1	0	0	0	0	0	0	0	1	10667	755	27	1		1	NR0B1	23	30326947	Silent	SNP	C	TCGA-CQ-6228-01A-11D-1912-08		30326947	124943613	120	20249											
UBQLN2	29978	broad.mit.edu	37	chrX	56591210	56591210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggggagtagttcctcctctGgggaaggtacgcagccttcc	6	10	14	11	1	1	0	0	0	1	0	4	2	4	2	4	5	2	4	4	5	3	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chrX:56591210G>A	uc004dus.2	+	1	1139	c.904G>A	c.(904-906)GGG>AGG	p.G302R	UBQLN2_uc011moq.1_Missense_Mutation_p.G302R	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	302						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						TTCCTCCTCTGGGGAAGGTAC	0.567													22	25					0	0	0	0	A	56591210	A	A	56591210	3	1	109	1	0	0	0	0	1	0	0	0	16965	1348	47	4	906	4	UBQLN2	23	56591210	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	26264263	56591210	98679350	121	20250											
GPRASP1	9737	broad.mit.edu	37	chrX	101912582	101912582	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgaggaaacccttgcttaTagcgtggattccccggaaca	10	10	11	10	2	0	1	0	1	0	0	1	4	1	4	3	3	4	1	3	3	4	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chrX:101912582T>C	uc004ejj.3	+	5	4542	c.3741T>C	c.(3739-3741)TAT>TAC	p.Y1247Y	GPRASP1_uc004eji.3_Silent_p.Y1247Y|GPRASP1_uc010nod.2_Silent_p.Y1247Y	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1247	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2						CCCTTGCTTATAGCGTGGATT	0.408													27	61					0	0	0	0	C	101912582	C	C	101912582	2	2	109	1	0	0	0	0	0	0	0	1	6761	1413	49	5		5	GPRASP1	23	101912582	Silent	SNP	T	TCGA-CQ-6228-01A-11D-1912-08	45321372	101912582	53357978	122	20251											
MST4	51765	broad.mit.edu	37	chrX	131197495	131197495	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gataataatggaatacctggGcggtggttcagcactggatc	11	10	13	7	1	1	0	1	0	0	0	2	3	1	2	1	5	2	2	1	5	4	4			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chrX:131197495G>A	uc004ewk.1	+	4	609	c.308G>A	c.(307-309)GGC>GAC	p.G103D	MST4_uc004ewl.1_Missense_Mutation_p.G26D|MST4_uc011mux.1_Missense_Mutation_p.G125D|MST4_uc010nrj.1_Missense_Mutation_p.G103D|MST4_uc004ewm.1_Missense_Mutation_p.G103D	NM_016542	NP_057626	Q9P289	MST4_HUMAN	serine/threonine protein kinase MST4 isoform 1	103	Protein kinase.				cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(3)|stomach(2)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(192;0.000127)					GAATACCTGGGCGGTGGTTCA	0.318													30	64					0	0	0	0	A	131197495	A	A	131197495	3	1	109	1	0	0	0	0	1	0	0	0	9945	1203	42	4	318	4	MST4	23	131197495	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	29284913	131197495	24073065	123	20252											
FAM58A	92002	broad.mit.edu	37	chrX	152860037	152860037	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggaaggagacctggaagcGcagaactctcagcatgagaa	14	5	13	9	1	1	3	1	1	1	3	2	7	1	5	1	3	3	2	1	3	4	0			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chrX:152860037G>T	uc010nug.2	-	2	314	c.211C>A	c.(211-213)CGC>AGC	p.R71S				Q8N1B3	FA58A_HUMAN	RecName: Full=Cyclin-related protein FAM58B;	133					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACCTGGAAGCGCAGAACTCTC	0.537													8	98					5.18039e-06	8.97935e-06	1	0	T	152860037	T	T	152860037	3	4	109	1	0	0	0	0	1	0	0	0	5622	1087	38	3	361	3	FAM58A	23	152860037	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	21662542	152860037	2410523	124	20253											
SSR4	6748	broad.mit.edu	37	chrX	153063240	153063240	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctatgaggttagattcttcGacgaggagtcctacagcctc	9	11	10	11	2	1	2	0	1	1	1	4	5	2	3	3	2	2	1	3	2	3	5			TCGA-CQ-6228-01A-11D-1912-08	TCGA-CQ-6228-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	655e502b-1a6e-4eab-a948-4120d6c31c29	4ce6601d-842c-4551-8a3e-a8892f66e1ed	g.chrX:153063240G>A	uc004fiw.2	+	4	371	c.322G>A	c.(322-324)GAC>AAC	p.D108N	SSR4_uc004fiv.2_Missense_Mutation_p.D119N	NM_006280	NP_006271	P51571	SSRD_HUMAN	signal sequence receptor, delta precursor	108	Lumenal (Potential).				intracellular protein transport	integral to membrane|Sec61 translocon complex	calcium ion binding|protein binding				0	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TAGATTCTTCGACGAGGAGTC	0.617													6	15					0	0	0	0	A	153063240	A	A	153063240	3	1	109	1	0	0	0	0	1	0	0	0	15259	1058	37	1	336	1	SSR4	23	153063240	Missense_Mutation	SNP	G	TCGA-CQ-6228-01A-11D-1912-08	203203	153063240	2207320	125	20254											
HRNR	388697	broad.mit.edu	37	chr1	152188526	152188527	+	Frame_Shift_Ins	INS	-	G	G																															acctgagccagacccatgtcINSggccactgctggaagaccaa																								rs145041332		TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr1:152188526_152188527insG	uc001ezt.1	-	3	5654_5655	c.5578_5579insC	c.(5578-5580)CGAfs	p.R1860fs		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1860	20.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGACCCATGTCGGCCACTGCTG	0.594													---	---	---								G	152188527	G	G	152188526	7	5	110	1	0	1	1	0	0	0	0	0	7398	884	31	0	2977	0	HRNR	1	152188526	Frame_Shift_Ins	INS	-	TCGA-CQ-6229-01A-11D-1912-08		152188526	97062095	1	20255											
TNR	7143	broad.mit.edu	37	chr1	175334302	175334302	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctcttcctcctcatcccTggggctgtagttaagaatga	8	13	8	12	0	2	2	1	1	1	1	6	2	5	2	3	2	0	3	3	2	3	3			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr1:175334302T>G	uc001gkp.1	-	10	2512	c.2431A>C	c.(2431-2433)AGG>CGG	p.R811R	TNR_uc009wwu.1_Silent_p.R811R	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	811	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCCTCATCCCTGGGGCTGTAG	0.522													17	48					0	0	0	0	G	175334302	G	G	175334302	2	3	110	1	0	0	0	0	0	0	0	1	16404	1579	55	5		5	TNR	1	175334302	Silent	SNP	T	TCGA-CQ-6229-01A-11D-1912-08	23145776	175334302	73916319	2	20256											
NUAK2	81788	broad.mit.edu	37	chr1	205290569	205290569	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccttcttcaccttcccgtagGtgcctttgcccagggtctcc	3	13	8	17	1	3	0	1	0	2	0	5	0	4	0	6	2	2	1	6	2	1	5			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr1:205290569G>A	uc001hce.2	-	1	315	c.188C>T	c.(187-189)ACC>ATC	p.T63I		NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	63	Protein kinase.|ATP (By similarity).				actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CTTCCCGTAGGTGCCTTTGCC	0.697													7	42					0	0	0	0	A	205290569	A	A	205290569	3	1	110	1	0	0	0	0	1	0	0	0	10767	1261	44	4	1726	4	NUAK2	1	205290569	Missense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08	29956267	205290569	43960052	3	20257											
KIF1A	547	broad.mit.edu	37	chr2	241658530	241658530	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttgtacatgtaggcataggGgcgccgcaccaccacgaagc	10	6	13	12	3	0	0	0	0	0	0	0	1	0	0	3	3	2	5	3	3	4	4			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr2:241658530G>T	uc002vzy.2	-	45	4950	c.4804C>A	c.(4804-4806)CCC>ACC	p.P1602T	KIF1A_uc010fzk.2_Missense_Mutation_p.P1703T|KIF1A_uc002vzw.2_Missense_Mutation_p.P263T|KIF1A_uc002vzx.2_Missense_Mutation_p.P329T	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1602	PH.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TAGGCATAGGGGCGCCGCACC	0.617													8	93					1.12685e-05	1.98424e-05	1	0	T	241658530	T	T	241658530	3	4	110	1	0	0	0	0	1	0	0	0	8322	1232	43	4	280	4	KIF1A	2	241658530	Missense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08		241658530	1540843	4	20258											
PLXNA1	5361	broad.mit.edu	37	chr3	126707784	126707784	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtactgacaacgtcaacaaGctgctgctgctggactatgc	11	9	10	11	1	1	1	1	1	0	0	1	2	1	2	0	1	8	5	0	1	5	2			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr3:126707784G>T	uc003ejg.2	+	1	283	c.279G>T	c.(277-279)AAG>AAT	p.K93N		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	116	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		ACGTCAACAAGCTGCTGCTGC	0.647													8	55					1.12685e-05	1.98424e-05	1	0	T	126707784	T	T	126707784	3	4	110	1	0	0	0	0	1	0	0	0	12174	962	34	4	350	4	PLXNA1	3	126707784	Missense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08		126707784	71314646	5	20259											
UGT2B4	7363	broad.mit.edu	37	chr4	70355227	70355227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgatgtgttactgaccatcGaccccagagaaaacaccaca	14	7	7	13	1	0	3	0	2	0	1	1	5	0	3	4	0	2	1	4	0	3	1			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr4:70355227G>A	uc003hek.3	-	3	979	c.932C>T	c.(931-933)TCG>TTG	p.S311L	UGT2B4_uc011cap.1_Missense_Mutation_p.S175L|UGT2B4_uc003hel.3_Missense_Mutation_p.S311L	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	311					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						ACTGACCATCGACCCCAGAGA	0.373													40	166					0	0	0	0	A	70355227	A	A	70355227	3	1	110	1	0	0	0	0	1	0	0	0	17029	1059	37	1	670	1	UGT2B4	4	70355227	Missense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08		70355227	120799049	6	20260											
STC2	8614	broad.mit.edu	37	chr5	172755126	172755126	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgggttggtggcgtcggtcCcccgcgccgggtcaaaggtg	3	8	19	11	5	1	0	1	0	0	0	3	0	2	0	3	6	0	1	3	6	1	1			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr5:172755126C>A	uc003mco.1	-	1	1381	c.71G>T	c.(70-72)GGG>GTG	p.G24V	STC2_uc003mcn.1_5'Flank	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	24					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GGCGTCGGTCCCCCGCGCCGG	0.637													18	78					3.32936e-07	6.12905e-07	1	0	A	172755126	A	A	172755126	3	1	110	1	0	0	0	0	1	0	0	0	15342	623	22	4	853	4	STC2	5	172755126	Missense_Mutation	SNP	C	TCGA-CQ-6229-01A-11D-1912-08		172755126	8160134	7	20261											
SKIV2L	6499	broad.mit.edu	37	chr6	31928456	31928456	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcccaggggggatggatgaAcccaccataacagatctgaa	13	7	11	10	0	1	3	0	2	1	1	2	5	2	5	3	4	2	0	3	4	3	2			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr6:31928456A>G	uc003nyn.1	+	6	872	c.483A>G	c.(481-483)GAA>GAG	p.E161E	RDBP_uc003nyk.2_5'Flank|RDBP_uc011dot.1_5'Flank|RDBP_uc003nyl.1_5'Flank|RDBP_uc003nym.1_5'Flank|SKIV2L_uc011dou.1_Silent_p.E3E|SKIV2L_uc011dov.1_Intron	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	161						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						GGATGGATGAACCCACCATAA	0.527													36	127					0	0	0	0	G	31928456	G	G	31928456	2	3	110	1	0	0	0	0	0	0	0	1	14424	40	2	5		5	SKIV2L	6	31928456	Silent	SNP	A	TCGA-CQ-6229-01A-11D-1912-08		31928456	139186611	8	20262											
SKIV2L	6499	broad.mit.edu	37	chr6	31931705	31931705	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggaccgcggagtgtacCtgtccctcctggcctccctc	4	9	10	18	2	0	0	0	0	0	0	5	2	4	2	7	3	1	1	7	3	1	1			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr6:31931705C>T	uc003nyn.1	+	16	2052	c.1663C>T	c.(1663-1665)CTG>TTG	p.L555L	SKIV2L_uc011dou.1_Silent_p.L397L|SKIV2L_uc011dov.1_Silent_p.L362L	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	555						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CGGAGTGTACCTGTCCCTCCT	0.622													66	165					0	0	0	0	T	31931705	T	T	31931705	2	4	110	1	0	0	0	0	0	0	0	1	14424	680	24	4		4	SKIV2L	6	31931705	Silent	SNP	C	TCGA-CQ-6229-01A-11D-1912-08	3249	31931705	139183362	9	20263											
SCUBE3	222663	broad.mit.edu	37	chr6	35209013	35209013	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgcccagcaggccagggtCggctgcactggaatggcaaa	9	5	14	13	1	0	0	0	0	0	0	1	1	0	1	3	5	3	4	3	5	2	0			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr6:35209013C>T	uc003okf.1	+	10	1171	c.1165C>T	c.(1165-1167)CGG>TGG	p.R389W	SCUBE3_uc003okg.1_Missense_Mutation_p.R388W|SCUBE3_uc003okh.1_Missense_Mutation_p.R276W	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	389	EGF-like 9; calcium-binding (Potential).				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						AGGCCAGGGTCGGCTGCACTG	0.582											OREG0017372	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	99					0	0	0	0	T	35209013	T	T	35209013	3	4	110	1	0	0	0	0	1	0	0	0	14011	875	31	1	1203	1	SCUBE3	6	35209013	Missense_Mutation	SNP	C	TCGA-CQ-6229-01A-11D-1912-08	3277308	35209013	135906054	10	20264											
FAM188B	84182	broad.mit.edu	37	chr7	30830851	30830851	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccaaccccaagaagagaGccggaaggtccctgagctct	12	4	10	15	1	1	3	0	1	1	2	2	5	2	4	5	2	3	1	5	2	4	0			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr7:30830851G>A	uc003tbt.2	+	5	811	c.734G>A	c.(733-735)AGC>AAC	p.S245N	FAM188B_uc010kwe.2_Missense_Mutation_p.S216N	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	245											0						CAAGAAGAGAGCCGGAAGGTC	0.547													16	133					0	0	0	0	A	30830851	A	A	30830851	3	1	110	1	0	0	0	0	1	0	0	0	5543	971	34	4	752	4	FAM188B	7	30830851	Missense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08		30830851	128307812	11	20265											
ABCA13	154664	broad.mit.edu	37	chr7	48390325	48390325	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttggtcaatctctcttcctgCgtggcactgaaccgtttcca	6	14	8	13	2	3	1	1	1	2	0	6	1	5	1	3	2	2	2	3	2	2	3			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr7:48390325C>T	uc003toq.2	+	30	10315	c.10290C>T	c.(10288-10290)TGC>TGT	p.C3430C	ABCA13_uc010kys.1_Silent_p.C504C|ABCA13_uc003tos.1_Silent_p.C256C	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3430					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TCTCTTCCTGCGTGGCACTGA	0.522													34	70					0	0	0	0	T	48390325	T	T	48390325	2	4	110	1	0	0	0	0	0	0	0	1	31	776	27	1		1	ABCA13	7	48390325	Silent	SNP	C	TCGA-CQ-6229-01A-11D-1912-08	17559474	48390325	110748338	12	20266											
SEMA3D	223117	broad.mit.edu	37	chr7	84651711	84651711	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctagttttagcttacctgtTccaagaaacattacatcgta	12	15	5	9	1	1	1	0	0	1	1	3	1	2	1	2	0	4	4	2	0	7	7			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr7:84651711T>G	uc003uic.2	-	11	1450	c.1410A>C	c.(1408-1410)GGA>GGC	p.G470G	SEMA3D_uc010led.2_Silent_p.G470G|SEMA3D_uc003uib.2_Silent_p.G109G	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	470	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						GCTTACCTGTTCCAAGAAACA	0.333													20	124					0	0	0	0	G	84651711	G	G	84651711	2	3	110	1	0	0	0	0	0	0	0	1	14092	1770	62	5		5	SEMA3D	7	84651711	Silent	SNP	T	TCGA-CQ-6229-01A-11D-1912-08	36261386	84651711	74486952	13	20267											
ERICH1	157697	broad.mit.edu	37	chr8	642491	642491	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attttaccttctgtgtcatcCccgctggaggcgttctcggg	4	14	11	12	3	3	0	1	0	2	0	5	1	4	1	3	3	1	2	3	3	1	4			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr8:642491C>G	uc003wph.2	-	3	356	c.291G>C	c.(289-291)GGG>GGC	p.G97G	ERICH1_uc011kwh.1_Silent_p.G97G|ERICH1_uc003wpe.1_Intron	NM_207332	NP_997215	Q86X53	ERIC1_HUMAN	glutamate-rich 1	97										large_intestine(2)	2		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		CTGTGTCATCCCCGCTGGAGG	0.557													6	88					0	0	0	0	G	642491	G	G	642491	2	3	110	1	0	0	0	0	0	0	0	1	5254	610	22	4		4	ERICH1	8	642491	Silent	SNP	C	TCGA-CQ-6229-01A-11D-1912-08		642491	145721531	14	20268											
RUNX1T1	862	broad.mit.edu	37	chr8	92988161	92988161	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccagatctcctctggcacGtatccagacgcaggcctgtg	7	10	10	14	2	2	2	0	0	2	2	5	2	4	2	4	2	0	3	4	2	1	2			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr8:92988161G>A	uc003yfd.2	-	9	1404	c.1320C>T	c.(1318-1320)TAC>TAT	p.Y440Y	RUNX1T1_uc003yfc.1_Silent_p.Y413Y|RUNX1T1_uc003yfe.1_Silent_p.Y403Y|RUNX1T1_uc010mao.2_Silent_p.Y413Y|RUNX1T1_uc011lgi.1_Silent_p.Y451Y|RUNX1T1_uc010man.1_Silent_p.Y65Y|RUNX1T1_uc003yfb.1_Silent_p.Y403Y	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	440					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CCTCTGGCACGTATCCAGACG	0.483													25	143					0	0	0	0	A	92988161	A	A	92988161	2	1	110	1	0	0	0	0	0	0	0	1	13812	1140	40	1		1	RUNX1T1	8	92988161	Silent	SNP	G	TCGA-CQ-6229-01A-11D-1912-08	92345670	92988161	53375861	15	20269											
CDKN2A	1029	broad.mit.edu	37	chr9	21971048	21971058	+	Frame_Shift_Del	DEL	GCCGCGCCCCG	-	-																															ccaggcatcgcgcacgtccaGccgcgccccggcccggtgca																								rs143282362		TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr9:21971048_21971058delGCCGCGCCCCG	uc003zpk.2	-	2	512_522	c.300_310delCGGGGCGCGGC	c.(298-312)GCCGGGGCGCGGCTGfs	p.A100fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Frame_Shift_Del_p.R156fs	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	100_104	ANK 3.		Missing.		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.G101G(3)|p.A100S(3)|p.A102V(3)|p.L104fs*42(2)|p.A102A(2)|p.A102E(2)|p.A100P(2)|p.H83fs*2(2)|p.R103Q(1)|p.R103R(1)|p.T93_D105del(1)|p.A100V(1)|p.G101fs*17(1)|p.A68fs*3(1)|p.A102fs*18(1)|p.R103fs*43(1)|p.G101W(1)|p.A102P(1)|p.A102T(1)|p.A102fs*42(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGCACGTCCAGCCGCGCCCCGGCCCGGTGCA	0.758		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---								-	21971058	-	-	21971048	7	5	110	1	0	1	0	1	0	0	0	0	3176	971	34	0	168	0	CDKN2A	9	21971048	Frame_Shift_Del	DEL	GCCGCGCCCCG	TCGA-CQ-6229-01A-11D-1912-08		21971048	119242383	16	20270											
NR6A1	2649	broad.mit.edu	37	chr9	127287138	127287138	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccagctgtgaggcactggTcagacccctgatatctgtgg	7	11	12	11	0	2	3	1	2	1	1	3	3	3	3	3	3	1	2	3	3	1	2			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr9:127287138T>G	uc004bor.1	-	9	1394	c.1216A>C	c.(1216-1218)ACC>CCC	p.T406P	NR6A1_uc004boq.1_Missense_Mutation_p.T401P|NR6A1_uc010mwq.1_Missense_Mutation_p.T402P	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	406					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GAGGCACTGGTCAGACCCCTG	0.413													11	22					0	0	0	0	G	127287138	G	G	127287138	3	3	110	1	0	0	0	0	1	0	0	0	10691	1667	58	5	234	5	NR6A1	9	127287138	Missense_Mutation	SNP	T	TCGA-CQ-6229-01A-11D-1912-08	105316090	127287138	13926293	17	20271											
EFCAB4A	283229	broad.mit.edu	37	chr11	828915	828915	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtttgaaagtctggacCgggctcacactggcttcctc	6	12	11	12	1	2	1	1	1	1	0	4	2	3	2	2	3	0	3	2	3	1	2			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr11:828915C>T	uc001lrv.2	+	2	607	c.229C>T	c.(229-231)CGG>TGG	p.R77W	EFCAB4A_uc010qwt.1_Missense_Mutation_p.R77W|EFCAB4A_uc009ycm.1_Missense_Mutation_p.R77W|EFCAB4A_uc001lrw.2_5'Flank			Q8N4Y2	EFC4A_HUMAN	RecName: Full=EF-hand calcium-binding domain-containing protein 4A;	77	EF-hand 2.				store-operated calcium entry		calcium ion binding				0		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAGTCTGGACCGGGCTCACAC	0.657													7	91					0	0	0	0	T	828915	T	T	828915	3	4	110	1	0	0	0	0	1	0	0	0	4958	643	23	1	235	1	EFCAB4A	11	828915	Missense_Mutation	SNP	C	TCGA-CQ-6229-01A-11D-1912-08		828915	134177601	18	20272											
CPT1A	1374	broad.mit.edu	37	chr11	68548198	68548198	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgaagacaacaaacgtgaaCgacttgtcaaaccacctacg	16	7	7	11	3	1	3	1	2	0	1	1	4	1	3	2	0	5	0	2	0	6	3			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr11:68548198C>T	uc001oog.3	-	12	1538	c.1368G>A	c.(1366-1368)TCG>TCA	p.S456S	CPT1A_uc001oof.3_Silent_p.S456S|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	456	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CAAACGTGAACGACTTGTCAA	0.493													15	53					0	0	0	0	T	68548198	T	T	68548198	2	4	110	1	0	0	0	0	0	0	0	1	3846	523	19	1		1	CPT1A	11	68548198	Silent	SNP	C	TCGA-CQ-6229-01A-11D-1912-08	67719283	68548198	66458318	19	20273											
UCP3	7352	broad.mit.edu	37	chr11	73717220	73717220	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctggtcactcactgtccgCgcctttgggggtgtacacct	5	11	11	14	2	2	0	2	0	0	0	3	0	3	0	4	3	1	1	4	3	1	2			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr11:73717220C>T	uc001our.2	-	3	686	c.331G>A	c.(331-333)GCG>ACG	p.A111T	UCP3_uc001ous.2_Missense_Mutation_p.A111T	NM_003356	NP_003347	P55916	UCP3_HUMAN	uncoupling protein 3 isoform UCP3L	111					mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			pancreas(1)	1	Breast(11;2.08e-05)					TCACTGTCCGCGCCTTTGGGG	0.612													15	34					0	0	0	0	T	73717220	T	T	73717220	3	4	110	1	0	0	0	0	1	0	0	0	17000	768	27	1	631	1	UCP3	11	73717220	Missense_Mutation	SNP	C	TCGA-CQ-6229-01A-11D-1912-08	5169022	73717220	61289296	20	20274											
UPF3A	65110	broad.mit.edu	37	chr13	115048325	115048325	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttcagtctttatcctcatCtctactcaagagcatacatt	11	16	3	11	0	5	1	3	0	2	1	7	1	6	1	1	0	3	1	1	0	4	6			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr13:115048325C>T	uc001vup.2	+	3	365	c.328C>T	c.(328-330)CTC>TTC	p.L110F	UPF3A_uc010tkn.1_Missense_Mutation_p.L110F|UPF3A_uc001vuq.2_Missense_Mutation_p.L110F|UPF3A_uc001vus.2_Intron|UPF3A_uc001vur.2_RNA	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	110	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		TTATCCTCATCTCTACTCAAG	0.343													8	45					0	0	0	0	T	115048325	T	T	115048325	3	4	110	1	0	0	0	0	1	0	0	0	17073	913	32	2	338	2	UPF3A	13	115048325	Missense_Mutation	SNP	C	TCGA-CQ-6229-01A-11D-1912-08		115048325	121553	21	20275											
ZSCAN2	54993	broad.mit.edu	37	chr15	85165178	85165178	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaatccacactggggagaaGccctacaaatgccccgagtg	12	5	11	13	2	0	1	0	0	0	1	1	4	1	1	4	2	3	0	4	2	4	1			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr15:85165178G>A	uc002bkr.2	+	3	1978	c.1752G>A	c.(1750-1752)AAG>AAA	p.K584K	ZSCAN2_uc010bmz.1_Silent_p.K582K|ZSCAN2_uc010bna.2_Silent_p.K434K|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	584					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		CTGGGGAGAAGCCCTACAAAT	0.483													10	71					0	0	0	0	A	85165178	A	A	85165178	2	1	110	1	0	0	0	0	0	0	0	1	18298	962	34	4		4	ZSCAN2	15	85165178	Silent	SNP	G	TCGA-CQ-6229-01A-11D-1912-08		85165178	17366214	22	20276											
C15orf32	145858	broad.mit.edu	37	chr15	93015669	93015669	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgagtggatggtttgatgctGaagccaacattgttaacacc	11	11	11	8	1	0	2	0	2	0	0	0	4	0	3	2	2	4	3	2	2	3	3			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr15:93015669G>A	uc002brc.1	+	1	763	c.291G>A	c.(289-291)CTG>CTA	p.L97L	C15orf32_uc010bod.1_RNA	NM_153040	NP_694585	Q32M92	CO032_HUMAN	hypothetical protein LOC145858	97										ovary(1)	1	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			GTTTGATGCTGAAGCCAACAT	0.294													4	75					0	0	0	0	A	93015669	A	A	93015669	2	1	110	1	0	0	0	0	0	0	0	1	1796	1277	45	2		2	C15orf32	15	93015669	Silent	SNP	G	TCGA-CQ-6229-01A-11D-1912-08	7850491	93015669	9515723	23	20277											
ZNF434	54925	broad.mit.edu	37	chr16	3433182	3433182	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacaatgaggctggaactCtggttgaagcttttcccaca	10	11	11	9	0	1	2	0	2	1	0	2	4	2	4	1	4	2	3	1	4	3	3			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr16:3433182C>A	uc002cuz.2	-	6	1930	c.1128G>T	c.(1126-1128)CAG>CAT	p.Q376H	ZNF434_uc002cux.3_Missense_Mutation_p.Q587H|ZNF434_uc010uwx.1_Missense_Mutation_p.Q299H|ZNF434_uc002cuy.3_Missense_Mutation_p.Q299H	NM_017810	NP_060280	Q9NX65	ZN434_HUMAN	zinc finger protein 434	376	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGCTGGAACTCTGGTTGAAGC	0.532													18	61					7.07596e-05	0.000121947	1	0	A	3433182	A	A	3433182	3	1	110	1	0	0	0	0	1	0	0	0	17975	912	32	2	333	2	ZNF434	16	3433182	Missense_Mutation	SNP	C	TCGA-CQ-6229-01A-11D-1912-08		3433182	86921571	24	20278											
TP53	7157	broad.mit.edu	37	chr17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcaccaccacactatgtcGaaaagtgtttctgtcatcca	11	10	8	12	1	2	0	1	0	1	0	4	1	3	0	3	1	0	2	3	1	3	2			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	9					0	0	0	0	A	7578212	A	A	7578212	4	1	110	1	0	0	0	0	0	1	0	0	16448	1066	37	1	657	1	TP53	17	7578212	Nonsense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08		7578212	73616998	25	20279											
ALOXE3	59344	broad.mit.edu	37	chr17	8000028	8000028	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctggttccgctcctggatgtCccttgagatctgggccaggc	4	11	13	13	1	1	1	0	1	1	1	4	3	4	2	4	4	0	2	4	4	0	2			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr17:8000028C>T	uc010cnr.2	-	16	2423	c.2053G>A	c.(2053-2055)GAC>AAC	p.D685N	ALOXE3_uc002gka.2_Missense_Mutation_p.D841N|ALOXE3_uc010vuo.1_Missense_Mutation_p.D817N	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	685	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						TCCTGGATGTCCCTTGAGATC	0.632													7	138					0	0	0	0	T	8000028	T	T	8000028	3	4	110	1	0	0	0	0	1	0	0	0	542	855	30	2	86	2	ALOXE3	17	8000028	Missense_Mutation	SNP	C	TCGA-CQ-6229-01A-11D-1912-08	421816	8000028	73195182	26	20280											
CCL3	6348	broad.mit.edu	37	chr17	34416628	34416628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgaagcagcaggcggtcGgcgtgtcagcagcaactgtg	9	6	16	10	3	1	1	1	1	0	0	2	1	1	1	0	3	6	5	0	3	2	0			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr17:34416628G>A	uc002hkv.2	-	2	191	c.89C>T	c.(88-90)CCG>CTG	p.P30L		NM_002983	NP_002974	P10147	CCL3_HUMAN	chemokine (C-C motif) ligand 3	30					cell-cell signaling|cellular calcium ion homeostasis|cellular component movement|cytoskeleton organization|exocytosis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|regulation of viral genome replication	extracellular space|soluble fraction	chemoattractant activity|chemokine activity|signal transducer activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCAGGCGGTCGGCGTGTCAGC	0.552													14	147					0	0	0	0	A	34416628	A	A	34416628	3	1	110	1	0	0	0	0	1	0	0	0	2914	1116	39	1	197	1	CCL3	17	34416628	Missense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08	26416600	34416628	46778582	27	20281											
KRT28	162605	broad.mit.edu	37	chr17	38950249	38950249	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctggatctgcgccagctgcGtacagtagttgctctcggtc	5	11	12	13	3	2	0	0	0	2	0	4	1	2	1	2	2	5	5	2	2	2	3			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr17:38950249G>A	uc002hvh.1	-	6	1094	c.1028C>T	c.(1027-1029)ACG>ATG	p.T343M		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	343	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CGCCAGCTGCGTACAGTAGTT	0.572													39	154					0	0	0	0	A	38950249	A	A	38950249	3	1	110	1	0	0	0	0	1	0	0	0	8504	1145	40	1	378	1	KRT28	17	38950249	Missense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08	4533621	38950249	42244961	28	20282											
SEPT4	5414	broad.mit.edu	37	chr17	56604314	56604314	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcagttctccatcatccGtggtgtcctccaggaaacgc	7	11	9	14	2	3	0	2	0	1	0	7	1	6	1	4	2	2	2	4	2	1	1			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr17:56604314G>A	uc002iwm.1	-	2	214	c.86C>T	c.(85-87)ACG>ATG	p.T29M	SEPT4_uc002iwk.1_Translation_Start_Site|SEPT4_uc010wnw.1_Translation_Start_Site|SEPT4_uc002iwl.1_Translation_Start_Site|SEPT4_uc002iwn.1_Intron|SEPT4_uc002iwo.1_Missense_Mutation_p.T10M|SEPT4_uc002iwp.1_Missense_Mutation_p.T10M|SEPT4_uc010wnx.1_Missense_Mutation_p.T44M|SEPT4_uc010wny.1_Missense_Mutation_p.T21M|SEPT4_uc010dcy.1_Intron	NM_004574	NP_004565	O43236	SEPT4_HUMAN	septin 4 isoform 1	29					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCCATCATCCGTGGTGTCCTC	0.478													13	129					0	0	0	0	A	56604314	A	A	56604314	3	1	110	1	0	0	0	0	1	0	0	0	14131	1145	40	1	1479	1	SEPT4	17	56604314	Missense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08	17654065	56604314	24590896	29	20283											
PIAS4	51588	broad.mit.edu	37	chr19	4013192	4013192	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcgctgtgcccaggactcCgctggcaggccccaatattg	6	7	13	15	3	0	0	0	0	0	0	1	1	1	1	4	4	1	3	4	4	2	2	rs2289867		TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr19:4013192C>T	uc002lzg.2	+	2	309	c.299C>T	c.(298-300)CCG>CTG	p.P100L		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	100					positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGGACTCCGCTGGCAGGC	0.652													5	88					0	0	0	0	T	4013192	T	T	4013192	3	4	110	1	0	0	0	0	1	0	0	0	11933	652	23	1	305	1	PIAS4	19	4013192	Missense_Mutation	SNP	C	TCGA-CQ-6229-01A-11D-1912-08		4013192	55115791	30	20284											
CLC	1178	broad.mit.edu	37	chr19	40224981	40224981	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	attcttggccatcctgaaagGgcatattcttggattccacc	9	13	8	11	0	2	1	0	1	2	0	4	2	4	2	4	3	0	1	4	3	2	6			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr19:40224981G>A	uc002omh.2	-	3	321	c.245C>T	c.(244-246)CCC>CTC	p.P82L		NM_001828	NP_001819	Q05315	LPPL_HUMAN	Charcot-Leyden crystal protein	82	Galectin.				lipid catabolic process|multicellular organismal development		carboxylesterase activity|lysophospholipase activity|sugar binding				0	all_cancers(60;2.99e-06)|all_lung(34;4.7e-08)|Lung NSC(34;5.46e-08)|Ovarian(47;0.06)	Renal(1328;0.000147)|Hepatocellular(1079;0.0202)|Myeloproliferative disorder(2;0.0255)	Epithelial(26;6.43e-25)|OV - Ovarian serous cystadenocarcinoma(5;1.07e-24)|all cancers(26;8.38e-23)	GBM - Glioblastoma multiforme(1328;4.97e-06)|STAD - Stomach adenocarcinoma(1328;0.00655)		ATCCTGAAAGGGCATATTCTT	0.537													9	90					0	0	0	0	A	40224981	A	A	40224981	3	1	110	1	0	0	0	0	1	0	0	0	3471	1232	43	4	191	4	CLC	19	40224981	Missense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08	36211789	40224981	18904002	31	20285											
MAPRE1	22919	broad.mit.edu	37	chr20	31424527	31424528	+	Frame_Shift_Del	DEL	TA	-	-																															agaagtttttcgatgcaaacTatgatggaaaagactatgac																								rs142135206		TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr20:31424527_31424528delTA	uc002wyh.2	+	4	494_495	c.355_356delTA	c.(355-357)TATfs	p.Y119fs		NM_012325	NP_036457	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family,	119					cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding				0						CGATGCAAACTATGATGGAAAA	0.411													---	---	---								-	31424528	-	-	31424527	7	5	110	1	0	1	0	1	0	0	0	0	9347	1522	53	0	365	0	MAPRE1	20	31424527	Frame_Shift_Del	DEL	TA	TCGA-CQ-6229-01A-11D-1912-08		31424527	31600993	32	20286											
APCDD1L	164284	broad.mit.edu	37	chr20	57035926	57035926	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgaagaccccctgtgctggGgtgcttctgcagcgatggcc	5	9	15	12	1	1	2	0	1	1	1	1	3	1	2	3	3	4	3	3	3	1	1			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr20:57035926G>C	uc002xze.1	-	4	1612	c.1426C>G	c.(1426-1428)CCC>GCC	p.P476A	APCDD1L_uc010zzp.1_Missense_Mutation_p.P487A	NM_153360	NP_699191	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated	476						integral to membrane				ovary(1)	1	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			CCTGTGCTGGGGTGCTTCTGC	0.612													12	55					0	0	0	0	C	57035926	C	C	57035926	3	2	110	1	0	0	0	0	1	0	0	0	766	1232	43	4	83	4	APCDD1L	20	57035926	Missense_Mutation	SNP	G	TCGA-CQ-6229-01A-11D-1912-08	25611399	57035926	5989594	33	20287											
MORC2	22880	broad.mit.edu	37	chr22	31328614	31328614	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaatgcggaggcattcggAagtggagggctctgcgacag	9	7	16	9	3	2	0	1	0	1	0	3	4	2	3	0	5	2	2	0	5	2	1			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr22:31328614A>C	uc003aje.1	-	24	3843	c.2479T>G	c.(2479-2481)TCC>GCC	p.S827A		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	889							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						AGGCATTCGGAAGTGGAGGGC	0.592													8	62					0	0	0	0	C	31328614	C	C	31328614	3	2	110	1	0	0	0	0	1	0	0	0	9755	246	9	5	449	5	MORC2	22	31328614	Missense_Mutation	SNP	A	TCGA-CQ-6229-01A-11D-1912-08		31328614	19975952	34	20288											
ZNF185	7739	broad.mit.edu	37	chrX	152083334	152083334	+	Frame_Shift_Del	DEL	A	-	-																															gaaccacgctgaagggggacAagagctggattaccaagcag																										TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chrX:152083334delA	uc010ntv.1	+	2	152	c.115delA	c.(115-117)AAGfs	p.K39fs	ZNF185_uc011myg.1_Frame_Shift_Del_p.K39fs|ZNF185_uc011myh.1_Frame_Shift_Del_p.K39fs|ZNF185_uc011myi.1_Frame_Shift_Del_p.K39fs|ZNF185_uc011myj.1_Frame_Shift_Del_p.K39fs|ZNF185_uc011myk.1_Frame_Shift_Del_p.K39fs	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	39						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGGGGGACAAGAGCTGGAT	0.607													---	---	---								-	152083334	-	-	152083334	7	5	110	1	0	1	0	1	0	0	0	0	17819	131	5	0	121	0	ZNF185	23	152083334	Frame_Shift_Del	DEL	A	TCGA-CQ-6229-01A-11D-1912-08		152083334	3187226	35	20289											
C1orf159	54991	broad.mit.edu	37	chr1	1019763	1019763	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggcggggggatcattgcagCcttgaaaaggagagaaaggc	12	6	17	6	1	1	2	1	1	0	1	1	5	1	4	1	6	2	1	1	6	3	2			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr1:1019763C>T	uc001act.2	-	11	1066	c.580G>A	c.(580-582)GCT>ACT	p.A194T	C1orf159_uc001acu.2_Missense_Mutation_p.A158T|C1orf159_uc001acr.2_RNA|C1orf159_uc001acs.2_RNA|C1orf159_uc010nyd.1_RNA|C1orf159_uc001acm.2_Intron|C1orf159_uc009vju.1_Missense_Mutation_p.A136T|C1orf159_uc001acn.2_Missense_Mutation_p.A158T|C1orf159_uc001acp.2_Missense_Mutation_p.A158T	NM_017891	NP_060361	Q96HA4	CA159_HUMAN	hypothetical protein LOC54991	194						integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		ATCATTGCAGCCTTGAAAAGG	0.622													7	16					0	0	0	0	T	1019763	T	T	1019763	3	4	111	1	0	0	0	0	1	0	0	0	2017	753	26	4	132	4	C1orf159	1	1019763	Missense_Mutation	SNP	C	TCGA-CQ-7065-01A-11D-2078-08		1019763	248230858	1	20290											
SLC8A1	6546	broad.mit.edu	37	chr2	40655955	40655955	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagatgcacaaggaaatttTcatcctcctcaaagatatca	15	11	6	9	0	3	2	3	1	0	2	5	4	5	3	2	1	1	1	2	1	4	3			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr2:40655955T>C	uc002rrx.2	-	1	1490	c.1466A>G	c.(1465-1467)GAA>GGA	p.E489G	SLC8A1_uc002rry.2_Missense_Mutation_p.E489G|SLC8A1_uc002rrz.2_Missense_Mutation_p.E489G|SLC8A1_uc002rsa.2_Missense_Mutation_p.E489G|SLC8A1_uc002rsd.3_Missense_Mutation_p.E489G|SLC8A1_uc002rsb.1_Missense_Mutation_p.E489G|SLC8A1_uc010fan.1_Missense_Mutation_p.E489G|SLC8A1_uc002rsc.1_Missense_Mutation_p.E489G	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	489	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AAGGAAATTTTCATCCTCCTC	0.408													24	43					0	0	0	0	C	40655955	C	C	40655955	3	2	111	1	0	0	0	0	1	0	0	0	14770	1783	62	5	1603	5	SLC8A1	2	40655955	Missense_Mutation	SNP	T	TCGA-CQ-7065-01A-11D-2078-08		40655955	202543418	2	20291											
ERCC3	2071	broad.mit.edu	37	chr2	128046236	128046236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaactctggtaccacttacCgcagggaagaacaatgaccc	13	8	8	12	1	1	2	0	1	1	1	1	3	1	3	3	2	4	2	3	2	6	3	rs138897577		TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr2:128046236C>T	uc002toh.1	-	7	1122	c.1027G>A	c.(1027-1029)GGT>AGT	p.G343S	ERCC3_uc002toe.1_Missense_Mutation_p.G98S|ERCC3_uc002tof.1_Missense_Mutation_p.G279S|ERCC3_uc002tog.1_Missense_Mutation_p.G279S|ERCC3_uc010flx.1_Missense_Mutation_p.G98S	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	343	Helicase ATP-binding.|ATP (By similarity).				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TACCACTTACCGCAGGGAAGA	0.532			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				138	291					0	0	0	0	T	128046236	T	T	128046236	3	4	111	1	0	0	0	0	1	0	0	0	5238	666	23	1	1357	1	ERCC3	2	128046236	Missense_Mutation	SNP	C	TCGA-CQ-7065-01A-11D-2078-08	87390281	128046236	115153137	3	20292											
LRP1B	53353	broad.mit.edu	37	chr2	141806669	141806669	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcgtgaaagtctaaagcacGagggtttaccagattttcta	12	12	10	7	2	2	2	0	1	2	1	2	3	2	2	1	1	3	2	1	1	5	6			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr2:141806669G>A	uc002tvj.1	-	11	2647	c.1675C>T	c.(1675-1677)CGT>TGT	p.R559C	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	559	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTAAAGCACGAGGGTTTACC	0.433										TSP Lung(27;0.18)			42	111					0	0	0	0	A	141806669	A	A	141806669	3	1	111	1	0	0	0	0	1	0	0	0	9005	1058	37	1	12448	1	LRP1B	2	141806669	Missense_Mutation	SNP	G	TCGA-CQ-7065-01A-11D-2078-08	13760433	141806669	101392704	4	20293											
SCN2A	6326	broad.mit.edu	37	chr2	166245201	166245201	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaccctgttccgagtgatcCgtcttgccaggattggccga	6	11	11	13	3	1	1	0	1	1	0	3	4	3	2	5	2	2	1	5	2	1	4			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr2:166245201C>T	uc002udc.2	+	27	5175	c.4885C>T	c.(4885-4887)CGT>TGT	p.R1629C	SCN2A_uc002udd.2_Missense_Mutation_p.R1629C|SCN2A_uc002ude.2_Missense_Mutation_p.R1629C	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1629	Helical; Voltage-sensor; Name=S4 of repeat IV; (Potential).|IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	CCGAGTGATCCGTCTTGCCAG	0.433													19	59					0	0	0	0	T	166245201	T	T	166245201	3	4	111	1	0	0	0	0	1	0	0	0	13981	652	23	1	5083	1	SCN2A	2	166245201	Missense_Mutation	SNP	C	TCGA-CQ-7065-01A-11D-2078-08	24438532	166245201	76954172	5	20294											
TTN	7273	broad.mit.edu	37	chr2	179596537	179596537	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcaggctaaccagatgatCctgaatgaaagtcttatact	13	11	8	9	0	1	4	0	3	1	1	2	4	2	4	2	1	3	2	2	1	5	3			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr2:179596537C>A	uc010zfg.1	-	55	13557	c.13333G>T	c.(13333-13335)GAT>TAT	p.D4445Y	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D1106Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5372							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCAGATGATCCTGAATGAAA	0.502													38	97					6.33695e-27	7.22412e-27	1	0	A	179596537	A	A	179596537	3	1	111	1	0	0	0	0	1	0	0	0	16803	855	30	2	87684	2	TTN	2	179596537	Missense_Mutation	SNP	C	TCGA-CQ-7065-01A-11D-2078-08	13351336	179596537	63602836	6	20295											
IGFBP5	3488	broad.mit.edu	37	chr2	217543684	217543684	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctttctgcggtccttcttCactgcttcagccttcagctc	3	17	6	15	1	6	0	3	0	3	0	8	0	7	0	2	1	4	2	2	1	0	6			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr2:217543684C>T	uc002vgj.3	-	2	1230	c.456G>A	c.(454-456)GTG>GTA	p.V152V		NM_000599	NP_000590	P24593	IBP5_HUMAN	insulin-like growth factor binding protein 5	152					negative regulation of insulin-like growth factor receptor signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of translation|signal transduction		insulin-like growth factor I binding				0		Renal(323;0.0822)		Epithelial(149;2.1e-06)|all cancers(144;0.000165)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTCCTTCTTCACTGCTTCAG	0.597													29	37					0	0	0	0	T	217543684	T	T	217543684	2	4	111	1	0	0	0	0	0	0	0	1	7621	813	29	2		2	IGFBP5	2	217543684	Silent	SNP	C	TCGA-CQ-7065-01A-11D-2078-08	37947147	217543684	25655689	7	20296											
TWF2	11344	broad.mit.edu	37	chr3	52269072	52269072	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatcacaaccttgatgagccGcacagagccagcccgtgcct	11	6	9	15	2	1	3	1	2	0	1	1	3	1	3	5	0	5	1	5	0	2	1			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr3:52269072G>A	uc003ddd.2	-	2	227	c.76C>T	c.(76-78)CGG>TGG	p.R26W	TWF2_uc010hmc.2_Missense_Mutation_p.R26W	NM_007284	NP_009215	Q6IBS0	TWF2_HUMAN	twinfilin-like protein	26	ADF-H 1.					cytoskeleton|perinuclear region of cytoplasm	actin binding|ATP binding			stomach(1)|ovary(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;2.43e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TTGATGAGCCGCACAGAGCCA	0.582													24	19					0	0	0	0	A	52269072	A	A	52269072	3	1	111	1	0	0	0	0	1	0	0	0	16850	1086	38	1	1005	1	TWF2	3	52269072	Missense_Mutation	SNP	G	TCGA-CQ-7065-01A-11D-2078-08		52269072	145753358	8	20297											
MFN1	55669	broad.mit.edu	37	chr3	179080166	179080166	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagttaatcaactggcccaTgcccttcacatggacaaaga	14	8	7	12	0	2	1	2	0	0	1	2	2	2	2	2	2	2	1	2	2	3	2			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr3:179080166T>A	uc003fjs.2	+	5	558	c.432T>A	c.(430-432)CAT>CAA	p.H144Q	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.H172Q|MFN1_uc010hxc.2_5'UTR	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	144	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			AACTGGCCCATGCCCTTCACA	0.368													47	34					0	0	0	0	A	179080166	A	A	179080166	3	1	111	1	0	0	0	0	1	0	0	0	9576	1461	51	5	446	5	MFN1	3	179080166	Missense_Mutation	SNP	T	TCGA-CQ-7065-01A-11D-2078-08	126811094	179080166	18942264	9	20298											
TFRC	7037	broad.mit.edu	37	chr3	195789750	195789750	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccattcagtggcaccaaccGatccaaagtctccagcactc	11	7	7	16	1	2	0	1	0	1	0	5	1	3	0	5	1	2	2	5	1	2	1			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr3:195789750G>A	uc003fvz.3	-	12	1662	c.1379C>T	c.(1378-1380)TCG>TTG	p.S460L	TFRC_uc003fwa.3_Missense_Mutation_p.S460L|TFRC_uc010hzy.2_Missense_Mutation_p.S379L|TFRC_uc011btr.1_Missense_Mutation_p.S178L	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	460	Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		GGCACCAACCGATCCAAAGTC	0.448			T	BCL6	NHL								26	53					0	0	0	0	A	195789750	A	A	195789750	3	1	111	1	0	0	0	0	1	0	0	0	15878	1059	37	1	935	1	TFRC	3	195789750	Missense_Mutation	SNP	G	TCGA-CQ-7065-01A-11D-2078-08	16709584	195789750	2232680	10	20299											
SLIT2	9353	broad.mit.edu	37	chr4	20544192	20544192	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttggatacagtcgtccgatGtagcaacaagggtttgaagg	11	10	13	7	2	0	1	0	1	0	0	2	3	1	2	1	3	3	3	1	3	5	4			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr4:20544192G>A	uc003gpr.1	+	21	2423	c.2219G>A	c.(2218-2220)TGT>TAT	p.C740Y	SLIT2_uc003gps.1_Missense_Mutation_p.C732Y	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	740	LRRNT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						GTCGTCCGATGTAGCAACAAG	0.418													91	158					0	0	0	0	A	20544192	A	A	20544192	3	1	111	1	0	0	0	0	1	0	0	0	14804	1377	48	4	2301	4	SLIT2	4	20544192	Missense_Mutation	SNP	G	TCGA-CQ-7065-01A-11D-2078-08		20544192	170610084	11	20300											
ASB5	140458	broad.mit.edu	37	chr4	177136850	177136850	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tagcttcggatacagagtcgGcaaagttggtaaagagagct	13	9	13	6	2	0	2	0	0	0	2	2	4	0	3	0	3	3	5	0	3	5	5			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr4:177136850G>A	uc003iuq.1	-	7	907	c.891C>T	c.(889-891)TGC>TGT	p.C297C	ASB5_uc003iup.1_Silent_p.C244C	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	297	SOCS box.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TACAGAGTCGGCAAAGTTGGT	0.358													3	30					0	0	0	0	A	177136850	A	A	177136850	2	1	111	1	0	0	0	0	0	0	0	1	1028	1195	42	4		4	ASB5	4	177136850	Silent	SNP	G	TCGA-CQ-7065-01A-11D-2078-08	156592658	177136850	14017426	12	20301											
KCNN2	3781	broad.mit.edu	37	chr5	113829157	113829157	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaccaagcaaacactttggtGgacttggcaaaggtaagcct	13	8	11	9	0	0	0	0	0	0	0	0	2	0	1	2	4	3	3	2	4	4	3			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr5:113829157G>A	uc003kqo.2	+	7	1897	c.1440G>A	c.(1438-1440)GTG>GTA	p.V480V	KCNN2_uc003kqp.2_Silent_p.V132V|KCNN2_uc010jcg.2_RNA|uc003kqr.1_Intron	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	480	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		ACACTTTGGTGGACTTGGCAA	0.408													8	19					0	0	0	0	A	113829157	A	A	113829157	2	1	111	1	0	0	0	0	0	0	0	1	8118	1335	47	4		4	KCNN2	5	113829157	Silent	SNP	G	TCGA-CQ-7065-01A-11D-2078-08		113829157	67086103	13	20302											
CEP120	153241	broad.mit.edu	37	chr5	122725742	122725742	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacactgttggtgattttggCccagtaagtgtcttctcctt	6	16	10	9	0	2	1	0	1	2	0	3	2	2	1	2	2	0	2	2	2	1	6			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr5:122725742C>T	uc003ktk.2	-	9	1213	c.1131G>A	c.(1129-1131)GGG>GGA	p.G377G	CEP120_uc011cwq.1_Silent_p.G186G|CEP120_uc010jcz.1_Silent_p.G351G	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	377						centrosome				ovary(1)	1						GTGATTTTGGCCCAGTAAGTG	0.393													3	41					0	0	0	0	T	122725742	T	T	122725742	2	4	111	1	0	0	0	0	0	0	0	1	3261	726	26	4		4	CEP120	5	122725742	Silent	SNP	C	TCGA-CQ-7065-01A-11D-2078-08	8896585	122725742	58189518	14	20303											
PCDHA4	56144	broad.mit.edu	37	chr5	140189040	140189040	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tactcgcagcagaggaggccGagggtgtgctctggtgaggg	7	7	19	8	2	1	2	0	1	1	1	2	4	1	3	1	5	3	3	1	5	1	1	rs146943849	byFrequency	TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr5:140189040G>A	uc003lhi.2	+	1	2369	c.2268G>A	c.(2266-2268)CCG>CCA	p.P756P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.P756P|PCDHA4_uc011daa.1_Silent_p.P756P	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	756	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGGAGGCCGAGGGTGTGCT	0.652													4	56					0	0	0	0	A	140189040	A	A	140189040	2	1	111	1	0	0	0	0	0	0	0	1	11580	1045	37	1		1	PCDHA4	5	140189040	Silent	SNP	G	TCGA-CQ-7065-01A-11D-2078-08	17463298	140189040	40726220	15	20304											
PCDHA12	56137	broad.mit.edu	37	chr5	140255408	140255408	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gacaggccgctgcaggttttCcatgtggacgtggaggtgaa	8	9	16	8	2	0	1	0	1	0	0	1	4	1	3	2	5	1	3	2	5	1	2			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr5:140255408C>T	uc003lic.2	+	1	478	c.351C>T	c.(349-351)TTC>TTT	p.F117F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.F117F	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	117	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGGTTTTCCATGTGGACG	0.562													6	133					0	0	0	0	T	140255408	T	T	140255408	2	4	111	1	0	0	0	0	0	0	0	1	11576	854	30	2		2	PCDHA12	5	140255408	Silent	SNP	C	TCGA-CQ-7065-01A-11D-2078-08	66368	140255408	40659852	16	20305											
OCM	654231	broad.mit.edu	37	chr7	5920406	5920406	+	5'Flank	DEL	T	-	-																															tcttaatttaaaaaaaaaaaTaatctagacacacatacagt																								rs10235465		TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr7:5920406delT	uc003spe.3	+							NM_001097622	NP_001091091	P0CE72	ONCO_HUMAN	oncomodulin								calcium ion binding				0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		aaaaaaaaaaTAATCTAGACA	0.229													---	---	---								-	5920406	-	-	5920406	6	5	111	0	1	1	0	1	0	0	0	0	10875	1421	49	0		0	OCM	7	5920406	5'Flank	DEL	T	TCGA-CQ-7065-01A-11D-2078-08		5920406	153218257	17	20306											
EPHB4	2050	broad.mit.edu	37	chr7	100420084	100420084	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggcacagtctccgggaatCgagtcaggttcacagtcagc	10	7	13	11	2	4	0	3	0	1	0	6	3	4	1	1	3	1	2	1	3	1	1			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr7:100420084C>T	uc003uwn.1	-	4	1108	c.617G>A	c.(616-618)CGA>CAA	p.R206Q	EPHB4_uc003uwm.1_Missense_Mutation_p.R113Q|EPHB4_uc010lhj.1_Missense_Mutation_p.R206Q|EPHB4_uc011kkf.1_Missense_Mutation_p.R206Q|EPHB4_uc011kkg.1_Missense_Mutation_p.R206Q|EPHB4_uc011kkh.1_Missense_Mutation_p.R206Q	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	206	Extracellular (Potential).|Cys-rich.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					CTCCGGGAATCGAGTCAGGTT	0.652													5	14					0	0	0	0	T	100420084	T	T	100420084	3	4	111	1	0	0	0	0	1	0	0	0	5201	884	31	1	2402	1	EPHB4	7	100420084	Missense_Mutation	SNP	C	TCGA-CQ-7065-01A-11D-2078-08	94499678	100420084	58718579	18	20307											
CNBD1	168975	broad.mit.edu	37	chr8	87917339	87917339	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaatatcttatcagctcaCgatacatttatgaagcaata	16	12	5	8	1	3	1	2	1	1	0	3	2	3	1	0	0	4	3	0	0	8	6			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr8:87917339C>T	uc003ydy.2	+	3	237	c.189C>T	c.(187-189)CAC>CAT	p.H63H		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	63										ovary(3)	3						TATCAGCTCACGATACATTTA	0.343													6	20					0	0	0	0	T	87917339	T	T	87917339	2	4	111	1	0	0	0	0	0	0	0	1	3606	535	19	1		1	CNBD1	8	87917339	Silent	SNP	C	TCGA-CQ-7065-01A-11D-2078-08		87917339	58446683	19	20308											
RBP3	5949	broad.mit.edu	37	chr10	48383918	48383918	+	Frame_Shift_Del	DEL	G	-	-																															agatcttgtccagcagaactGgagggccttcatcaaagaag																										TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr10:48383918delG	uc001jez.2	-	3	3428	c.3314delC	c.(3313-3315)CCAfs	p.P1105fs		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	1105	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CAGCAGAACTGGAGGGCCTTC	0.537													---	---	---								-	48383918	-	-	48383918	7	5	111	1	0	1	0	1	0	0	0	0	13222	1348	47	0	437	0	RBP3	10	48383918	Frame_Shift_Del	DEL	G	TCGA-CQ-7065-01A-11D-2078-08		48383918	87150829	20	20309											
SLC25A22	79751	broad.mit.edu	37	chr11	791950	791950	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagcagccccagcagggActccgcgatgcccaggaagt	9	4	13	15	2	0	0	0	0	0	0	1	3	1	2	4	2	5	3	4	2	1	0			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr11:791950A>G	uc001lri.2	-	10	1279	c.937T>C	c.(937-939)TCC>CCC	p.S313P	CEND1_uc001lrh.1_5'Flank|SLC25A22_uc009yci.2_Missense_Mutation_p.S313P|SLC25A22_uc001lrj.2_Missense_Mutation_p.S313P	NM_024698	NP_078974	Q9H936	GHC1_HUMAN	mitochondrial glutamate carrier 1	313						integral to membrane|mitochondrial inner membrane|nucleus	L-glutamate transmembrane transporter activity|protein binding|symporter activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	L-Glutamic Acid(DB00142)	CCCAGCAGGGACTCCGCGATG	0.716													12	15					0	0	0	0	G	791950	G	G	791950	3	3	111	1	0	0	0	0	1	0	0	0	14549	275	10	5	38	5	SLC25A22	11	791950	Missense_Mutation	SNP	A	TCGA-CQ-7065-01A-11D-2078-08		791950	134214566	21	20310											
KCNJ1	3758	broad.mit.edu	37	chr11	128710112	128710112	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcccaaaaaagcgagtgacGacccatttccgaagatgttt	13	9	9	10	3	0	2	0	1	0	1	1	5	1	2	3	0	2	1	3	0	4	2			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr11:128710112G>A	uc001qeo.1	-	2	135	c.84C>T	c.(82-84)GTC>GTT	p.V28V	KCNJ1_uc001qep.1_Silent_p.V9V|KCNJ1_uc001qeq.1_Silent_p.V9V|KCNJ1_uc001qer.1_Silent_p.V9V|KCNJ1_uc001qes.1_Silent_p.V9V	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	28	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	AGCGAGTGACGACCCATTTCC	0.408													36	122					0	0	0	0	A	128710112	A	A	128710112	2	1	111	1	0	0	0	0	0	0	0	1	8082	1045	37	1		1	KCNJ1	11	128710112	Silent	SNP	G	TCGA-CQ-7065-01A-11D-2078-08	127918162	128710112	6296404	22	20311											
KRT5	3852	broad.mit.edu	37	chr12	52911705	52911706	+	Frame_Shift_Ins	INS	-	T	T																															caaagaacatcttcatgaagINSttaatctcatccatcagtgc																										TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr12:52911705_52911706insT	uc001san.2	-	4	1065_1066	c.902_903insA	c.(901-903)AACfs	p.N301fs	KRT5_uc009zmh.2_Frame_Shift_Ins_p.N301fs	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	301	Rod.|Coil 1B.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCTTCATGAAGTTAATCTCATC	0.421													---	---	---								T	52911706	T	T	52911705	7	5	111	1	0	1	1	0	0	0	0	0	8518	1020	36	0	893	0	KRT5	12	52911705	Frame_Shift_Ins	INS	-	TCGA-CQ-7065-01A-11D-2078-08		52911705	80940190	23	20312											
ITGA7	3679	broad.mit.edu	37	chr12	56079057	56079057	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcctcggggtgcttcgcccGtttgaagaatcccatctata	7	11	11	12	3	1	2	0	1	1	1	4	2	2	2	3	3	1	2	3	3	4	4			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr12:56079057G>A	uc001shh.2	-	25	3431	c.3211C>T	c.(3211-3213)CGG>TGG	p.R1071W	ITGA7_uc001shg.2_Missense_Mutation_p.R1067W|ITGA7_uc010sps.1_Missense_Mutation_p.R974W|ITGA7_uc001shf.2_Silent_p.N82N|ITGA7_uc009znw.2_Missense_Mutation_p.R314W|ITGA7_uc009znx.2_Missense_Mutation_p.R948W	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	1111	GFFKR motif.|Cytoplasmic (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						TGCTTCGCCCGTTTGAAGAAT	0.607													17	26					0	0	0	0	A	56079057	A	A	56079057	3	1	111	1	0	0	0	0	1	0	0	0	7920	1144	40	1	218	1	ITGA7	12	56079057	Missense_Mutation	SNP	G	TCGA-CQ-7065-01A-11D-2078-08	3167352	56079057	77772838	24	20313											
ARHGAP9	64333	broad.mit.edu	37	chr12	57871047	57871047	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtcccctccatggagccAgggttctgggttaggggagg	5	10	17	9	0	1	0	0	0	1	0	3	2	3	2	4	6	1	2	4	6	1	2			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr12:57871047A>T	uc001sod.2	-	8	1168	c.975T>A	c.(973-975)CCT>CCA	p.P325P	ARHGAP9_uc001sny.2_5'Flank|ARHGAP9_uc001snz.2_Silent_p.P70P|ARHGAP9_uc001soa.2_5'UTR|ARHGAP9_uc001sob.2_Silent_p.P254P|ARHGAP9_uc001soc.2_Silent_p.P254P|ARHGAP9_uc001soe.1_Silent_p.P333P|ARHGAP9_uc010sro.1_Silent_p.P254P	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	254					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			CCATGGAGCCAGGGTTCTGGG	0.527													14	36					0	0	0	0	T	57871047	T	T	57871047	2	4	111	1	0	0	0	0	0	0	0	1	889	175	7	5		5	ARHGAP9	12	57871047	Silent	SNP	A	TCGA-CQ-7065-01A-11D-2078-08	1791990	57871047	75980848	25	20314											
GPR109B	8843	broad.mit.edu	37	chr12	123200127	123200127	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgagtccagtgacattactcGatgcaacagcccaactgttt	11	10	8	12	2	0	1	0	1	0	0	2	3	1	1	2	0	5	2	2	0	3	2			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr12:123200127G>A	uc001ucy.3	-	1	1313	c.1158C>T	c.(1156-1158)ATC>ATT	p.I386I	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	386	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	GACATTACTCGATGCAACAGC	0.488													37	73					0	0	0	0	A	123200127	A	A	123200127	2	1	111	1	0	0	0	0	0	0	0	1	6664	1048	37	1		1	GPR109B	12	123200127	Silent	SNP	G	TCGA-CQ-7065-01A-11D-2078-08	65329080	123200127	10651768	26	20315											
FRY	10129	broad.mit.edu	37	chr13	32783208	32783208	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggctctccagaagccacgTcactggtcctgaacaacctc	9	7	10	15	1	2	2	1	1	1	1	5	2	3	2	4	3	3	1	4	3	3	0			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr13:32783208T>C	uc001utx.2	+	32	4733	c.4237T>C	c.(4237-4239)TCA>CCA	p.S1413P	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AGAAGCCACGTCACTGGTCCT	0.542													29	23					0	0	0	0	C	32783208	C	C	32783208	3	2	111	1	0	0	0	0	1	0	0	0	6097	1667	58	5	4363	5	FRY	13	32783208	Missense_Mutation	SNP	T	TCGA-CQ-7065-01A-11D-2078-08		32783208	82386670	27	20316											
PCDH17	27253	broad.mit.edu	37	chr13	58206802	58206802	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcgggaacatcggcagggAtgctcgactgcagcctgggc	8	6	16	11	3	0	0	0	0	0	0	3	4	0	2	1	4	4	3	1	4	1	0			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr13:58206802A>C	uc001vhq.1	+	1	1014	c.122A>C	c.(121-123)GAT>GCT	p.D41A	PCDH17_uc010aec.1_Missense_Mutation_p.D41A	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	41	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATCGGCAGGGATGCTCGACTG	0.662													3	25					0	0	0	0	C	58206802	C	C	58206802	3	2	111	1	0	0	0	0	1	0	0	0	11566	333	12	5	124	5	PCDH17	13	58206802	Missense_Mutation	SNP	A	TCGA-CQ-7065-01A-11D-2078-08	25423594	58206802	56963076	28	20317											
OR4Q3	441669	broad.mit.edu	37	chr14	20216210	20216210	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaacagtggtctgctgtcTcttgtctgcttcttggtctt	3	17	10	11	0	5	0	0	0	5	0	6	0	5	0	1	2	3	2	1	2	1	4			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr14:20216210T>C	uc010tkt.1	+	1	624	c.624T>C	c.(622-624)TCT>TCC	p.S208S		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTCTGCTGTCTCTTGTCTGCT	0.493													18	39					0	0	0	0	C	20216210	C	C	20216210	2	2	111	1	0	0	0	0	0	0	0	1	11135	1538	54	5		5	OR4Q3	14	20216210	Silent	SNP	T	TCGA-CQ-7065-01A-11D-2078-08		20216210	87133330	29	20318											
SDCCAG1	9147	broad.mit.edu	37	chr14	50255970	50255970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagaccctctgtccacctCtaggtttctggggctgtttc	5	13	10	13	0	3	1	0	0	3	1	5	2	4	1	3	3	0	3	3	3	1	3			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr14:50255970C>T	uc001wxc.2	-	28	2857	c.2789G>A	c.(2788-2790)AGA>AAA	p.R930K	SDCCAG1_uc010anj.1_Missense_Mutation_p.R930K|SDCCAG1_uc001wwz.2_Missense_Mutation_p.R130K|SDCCAG1_uc001wxa.2_Missense_Mutation_p.R210K|SDCCAG1_uc010tqi.1_Missense_Mutation_p.R909K|SDCCAG1_uc001wxe.2_Missense_Mutation_p.R888K	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	930						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		CTGTCCACCTCTAGGTTTCTG	0.413													46	101					0	0	0	0	T	50255970	T	T	50255970	3	4	111	1	0	0	0	0	1	0	0	0	14022	913	32	2	465	2	SDCCAG1	14	50255970	Missense_Mutation	SNP	C	TCGA-CQ-7065-01A-11D-2078-08	30039760	50255970	57093570	30	20319											
PPP4C	5531	broad.mit.edu	37	chr16	30096327	30096327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcatcatctttgaggctgctCcccaagagacacggggcatc	9	9	10	13	1	3	2	2	1	1	1	5	3	4	2	2	3	1	3	2	3	1	1			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr16:30096327C>T	uc002dwe.2	+	9	1012	c.868C>T	c.(868-870)CCC>TCC	p.P290S	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|PPP4C_uc002dwf.2_Missense_Mutation_p.P290S|PPP4C_uc002dwg.2_RNA|PPP4C_uc002dwh.2_Missense_Mutation_p.P211S	NM_002720	NP_002711	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	290					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			skin(1)	1						TGAGGCTGCTCCCCAAGAGAC	0.632													41	67					0	0	0	0	T	30096327	T	T	30096327	3	4	111	1	0	0	0	0	1	0	0	0	12462	855	30	2	898	2	PPP4C	16	30096327	Missense_Mutation	SNP	C	TCGA-CQ-7065-01A-11D-2078-08		30096327	60258426	31	20320											
TP53	7157	broad.mit.edu	37	chr17	7578394	7578394	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctatctgagcagcgctcaTggtgggggcagcgcctcaca	7	7	14	13	3	3	1	2	1	1	0	3	1	3	1	1	3	3	4	1	3	1	1			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr17:7578394T>G	uc002gim.2	-	5	730	c.536A>C	c.(535-537)CAT>CCT	p.H179P	TP53_uc002gig.1_Missense_Mutation_p.H179P|TP53_uc002gih.2_Missense_Mutation_p.H179P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47P|TP53_uc010cng.1_Missense_Mutation_p.H47P|TP53_uc002gii.1_Missense_Mutation_p.H47P|TP53_uc010cnh.1_Missense_Mutation_p.H179P|TP53_uc010cni.1_Missense_Mutation_p.H179P|TP53_uc002gij.2_Missense_Mutation_p.H179P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86P|TP53_uc002gio.2_Missense_Mutation_p.H47P|TP53_uc010vug.1_Missense_Mutation_p.H140P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	37					0	0	0	0	G	7578394	G	G	7578394	3	3	111	1	0	0	0	0	1	0	0	0	16448	1464	51	5	762	5	TP53	17	7578394	Missense_Mutation	SNP	T	TCGA-CQ-7065-01A-11D-2078-08		7578394	73616816	32	20321											
SLC47A1	55244	broad.mit.edu	37	chr17	19459314	19459314	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttcttcaccaggcatccTcggcatggtggagctgggcg	5	11	13	12	2	3	0	1	0	2	0	5	1	4	1	2	5	1	3	2	5	0	2			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr17:19459314T>C	uc002gvy.1	+	10	946	c.860T>C	c.(859-861)CTC>CCC	p.L287P	SLC47A1_uc010vyy.1_RNA|SLC47A1_uc002gvx.2_Missense_Mutation_p.L287P|SLC47A1_uc010vyz.1_Missense_Mutation_p.L264P|SLC47A1_uc010cqp.1_Intron|SLC47A1_uc010cqq.1_Missense_Mutation_p.L92P|SLC47A1_uc010vza.1_5'UTR|SLC47A1_uc010vzb.1_Missense_Mutation_p.L21P|SLC47A1_uc010vzc.1_5'UTR|SNORA59B_uc002gvz.1_5'Flank	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	287	Extracellular (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					CCAGGCATCCTCGGCATGGTG	0.592													21	31					0	0	0	0	C	19459314	C	C	19459314	3	2	111	1	0	0	0	0	1	0	0	0	14711	1551	54	5	898	5	SLC47A1	17	19459314	Missense_Mutation	SNP	T	TCGA-CQ-7065-01A-11D-2078-08	11880920	19459314	61735896	33	20322											
MUC16	94025	broad.mit.edu	37	chr19	9085093	9085093	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatactctcagccccatctGaaggtgtgtcaattacatct	11	12	7	11	0	4	1	2	1	3	0	5	2	4	1	2	1	3	0	2	1	5	2			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr19:9085093G>T	uc002mkp.2	-	1	6926	c.6722C>A	c.(6721-6723)TCA>TAA	p.S2241*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2241	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCCCCATCTGAAGGTGTGTC	0.468													13	24					0.000151284	0.000162702	1	0	T	9085093	T	T	9085093	4	4	111	1	0	0	0	0	0	1	0	0	10026	1294	45	2	37137	2	MUC16	19	9085093	Nonsense_Mutation	SNP	G	TCGA-CQ-7065-01A-11D-2078-08		9085093	50043890	34	20323											
CYTSA	23384	broad.mit.edu	37	chr22	24665426	24665428	+	5'Flank	DEL	CTT	-	-																															caccagggggcacagcactcCttctgtaggtatctctgtcg																										TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chr22:24665426_24665428delCTT	uc002zzw.2	+						CYTSA_uc002zzv.3_5'Flank|CYTSA_uc011ajq.1_5'Flank	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A						cell cycle|cell division						0						CACAGCACTCCTTCTGTAGGTAT	0.596													---	---	---								-	24665428	-	-	24665426	6	5	111	0	1	1	0	1	0	0	0	0	4226	696	24	0		0	CYTSA	22	24665426	5'Flank	DEL	CTT	TCGA-CQ-7065-01A-11D-2078-08		24665426	26639140	35	20324											
MAGEB2	4113	broad.mit.edu	37	chrX	30236705	30236705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacccagccatcatgcctcGtggtcagaagagtaagctcc	10	9	9	13	1	2	2	2	0	0	2	4	2	3	2	4	1	4	2	4	1	3	2			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chrX:30236705G>A	uc004dbz.2	+	2	111	c.8G>A	c.(7-9)CGT>CAT	p.R3H		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	3							protein binding			ovary(1)	1						ATCATGCCTCGTGGTCAGAAG	0.527													28	5					0	0	0	0	A	30236705	A	A	30236705	3	1	111	1	0	0	0	0	1	0	0	0	9229	1145	40	1	10	1	MAGEB2	23	30236705	Missense_Mutation	SNP	G	TCGA-CQ-7065-01A-11D-2078-08		30236705	125033855	36	20325											
MAGEC3	139081	broad.mit.edu	37	chrX	140985590	140985590	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccagtgcaagccccagtgTcatgtccaccaacttctgtc	8	9	9	15	0	2	0	1	0	1	0	4	0	3	0	5	1	3	1	5	1	2	1			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chrX:140985590T>C	uc011mwp.1	+	8	1904	c.1904T>C	c.(1903-1905)GTC>GCC	p.V635A	MAGEC3_uc004fbs.2_3'UTR|MAGEC3_uc010nsj.2_3'UTR	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	635	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGCCCCAGTGTCATGTCCACC	0.517													24	43					0	0	0	0	C	140985590	C	C	140985590	3	2	111	1	0	0	0	0	1	0	0	0	9235	1667	58	5	2301	5	MAGEC3	23	140985590	Missense_Mutation	SNP	T	TCGA-CQ-7065-01A-11D-2078-08	110748885	140985590	14284970	37	20326											
MAGEC1	9947	broad.mit.edu	37	chrX	140994879	140994879	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gactccctatctcctcactaCtttcctcagagccctcctca	7	12	3	19	0	4	1	3	0	1	1	8	2	7	1	5	0	2	0	5	0	2	3			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chrX:140994879C>G	uc004fbt.2	+	4	1975	c.1689C>G	c.(1687-1689)TAC>TAG	p.Y563*	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	563							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCTCACTACTTTCCTCAGA	0.572										HNSCC(15;0.026)			12	457					0	0	0	0	G	140994879	G	G	140994879	4	3	111	1	0	0	0	0	0	1	0	0	9233	576	20	4	1695	4	MAGEC1	23	140994879	Nonsense_Mutation	SNP	C	TCGA-CQ-7065-01A-11D-2078-08	9289	140994879	14275681	38	20327											
G6PD	2539	broad.mit.edu	37	chrX	153763390	153763390	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcaagccttacatctggcTcatgcaggactcgtgaatgt	9	10	11	11	2	2	1	1	1	1	0	3	2	2	2	1	3	3	3	1	3	3	1			TCGA-CQ-7065-01A-11D-2078-08	TCGA-CQ-7065-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	64c422bb-a531-4636-8e68-bdaf212df6dc	d1cb757d-641c-488c-a845-ee4a1075a662	g.chrX:153763390T>G	uc004fly.1	-	5	591	c.478A>C	c.(478-480)AGC>CGC	p.S160R	G6PD_uc004flx.1_Missense_Mutation_p.S190R	NM_001042351	NP_001035810	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase isoform b	160					cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			ovary(4)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TACATCTGGCTCATGCAGGAC	0.652													43	40					0	0	0	0	G	153763390	G	G	153763390	3	3	111	1	0	0	0	0	1	0	0	0	6180	1551	54	5	1105	5	G6PD	23	153763390	Missense_Mutation	SNP	T	TCGA-CQ-7065-01A-11D-2078-08	12768511	153763390	1507170	39	20328											
C1orf187	374946	broad.mit.edu	37	chr1	11779671	11779671	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctatgccaaattccaccggaAccgcagggttacacggagga	12	6	11	12	3	0	0	0	0	0	0	1	3	1	3	4	4	3	2	4	4	4	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:11779671A>G	uc001asr.1	+	7	1108	c.968A>G	c.(967-969)AAC>AGC	p.N323S	uc001ass.1_5'Flank	NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor	323					axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		TTCCACCGGAACCGCAGGGTT	0.682											OREG0013102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	22					0	0	0	0	G	11779671	G	G	11779671	3	3	112	1	0	0	0	0	1	0	0	0	2030	43	2	5	990	5	C1orf187	1	11779671	Missense_Mutation	SNP	A	TCGA-CQ-7067-01A-11D-2229-08		11779671	237470950	1	20329											
SLFNL1	200172	broad.mit.edu	37	chr1	41486124	41486124	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcatctccagccgctccaggGtgtctcgcagcaggcaggca	7	6	13	15	2	2	0	0	0	2	0	5	0	3	0	3	3	2	6	3	3	0	0			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:41486124G>A	uc001cgm.1	-	2	429	c.209C>T	c.(208-210)ACC>ATC	p.T70I	SLFNL1_uc009vwf.1_Missense_Mutation_p.T70I|SLFNL1_uc001cgn.1_Missense_Mutation_p.T70I|SLFNL1_uc009vwg.1_Missense_Mutation_p.T70I	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	70							ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				CCGCTCCAGGGTGTCTCGCAG	0.647													57	121					0	0	0	0	A	41486124	A	A	41486124	3	1	112	1	0	0	0	0	1	0	0	0	14802	1261	44	4	1030	4	SLFNL1	1	41486124	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	29706453	41486124	207764497	2	20330											
LRRIQ3	127255	broad.mit.edu	37	chr1	74507481	74507481	+	Frame_Shift_Del	DEL	A	-	-																															attggctgaggatatgcaggAaaaaaatgttgttttttctc																										TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:74507481delA	uc001dfy.3	-	7	1326	c.1134delT	c.(1132-1134)TTTfs	p.F378fs	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	378										ovary(2)	2						GATATGCAGGAAAAAAATGTT	0.348													---	---	---								-	74507481	-	-	74507481	7	5	112	1	0	1	0	1	0	0	0	0	9080	243	9	0	748	0	LRRIQ3	1	74507481	Frame_Shift_Del	DEL	A	TCGA-CQ-7067-01A-11D-2229-08	33021357	74507481	174743140	3	20331											
ZNF687	57592	broad.mit.edu	37	chr1	151261985	151261985	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtcttgtcctctgctctttgCccaaaaaaggaccatgctgg	8	12	9	12	0	3	0	0	0	3	0	4	1	4	1	3	2	3	2	3	2	3	2			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:151261985C>T	uc001exq.2	+	5	2701	c.2603C>T	c.(2602-2604)GCC>GTC	p.A868V	ZNF687_uc009wmo.2_Missense_Mutation_p.A868V|ZNF687_uc009wmp.2_Missense_Mutation_p.A868V	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	868	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTGCTCTTTGCCCAAAAAAGG	0.547													25	47					0	0	0	0	T	151261985	T	T	151261985	3	4	112	1	0	0	0	0	1	0	0	0	18159	739	26	4	2617	4	ZNF687	1	151261985	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	76754504	151261985	97988636	4	20332											
RYR2	6262	broad.mit.edu	37	chr1	237754082	237754082	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcggaggtcttctccaagaCggtggctggagggctccctg	5	8	16	12	3	2	1	0	0	2	1	4	3	3	3	2	6	0	2	2	6	1	1			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:237754082C>T	uc001hyl.1	+	31	4070	c.3950C>T	c.(3949-3951)ACG>ATG	p.T1317M		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1317	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCTCCAAGACGGTGGCTGGA	0.502													38	67					0	0	0	0	T	237754082	T	T	237754082	3	4	112	1	0	0	0	0	1	0	0	0	13834	536	19	1	4072	1	RYR2	1	237754082	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	86492097	237754082	11496539	5	20333											
RYR2	6262	broad.mit.edu	37	chr1	237947222	237947222	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatttcttttgtcttgtgcGgagacggatgagaatgaaac	11	13	12	5	2	2	3	0	2	2	2	2	7	2	4	0	2	2	0	0	2	3	4			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:237947222G>A	uc001hyl.1	+	90	12330	c.12210G>A	c.(12208-12210)GCG>GCA	p.A4070A	RYR2_uc010pya.1_Silent_p.A485A	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4070					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTCTTGTGCGGAGACGGATG	0.512													3	12					0	0	0	0	A	237947222	A	A	237947222	2	1	112	1	0	0	0	0	0	0	0	1	13834	1103	39	1		1	RYR2	1	237947222	Silent	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	193140	237947222	11303399	6	20334											
SLC5A7	60482	broad.mit.edu	37	chr2	108622601	108622601	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtccttcctggcagctttcGggtgcctggtgatggccatc	3	13	13	12	1	0	1	0	1	0	0	4	1	2	1	4	4	2	2	4	4	0	2			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr2:108622601G>A	uc002tdv.2	+	7	1114	c.838G>A	c.(838-840)GGG>AGG	p.G280R	SLC5A7_uc010ywm.1_Missense_Mutation_p.G33R|SLC5A7_uc010fjj.2_Missense_Mutation_p.G280R|SLC5A7_uc010ywn.1_Missense_Mutation_p.G167R	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	280	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GGCAGCTTTCGGGTGCCTGGT	0.522													13	77					0	0	0	0	A	108622601	A	A	108622601	3	1	112	1	0	0	0	0	1	0	0	0	14734	1116	39	1	860	1	SLC5A7	2	108622601	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08		108622601	134576772	7	20335											
SCN3A	6328	broad.mit.edu	37	chr2	165987867	165987867	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccagccttcttggaaatagtAataaggatccatggcaatga	14	10	9	8	0	1	1	0	1	1	0	2	3	2	3	3	3	1	2	3	3	5	5			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr2:165987867A>G	uc002ucx.2	-	16	2944	c.2452T>C	c.(2452-2454)TAC>CAC	p.Y818H	SCN3A_uc002ucy.2_Missense_Mutation_p.Y769H|SCN3A_uc002ucz.2_Missense_Mutation_p.Y769H|SCN3A_uc002uda.1_Missense_Mutation_p.Y638H|SCN3A_uc002udb.1_Missense_Mutation_p.Y638H	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	818						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TGGAAATAGTAATAAGGATCC	0.398													22	59					0	0	0	0	G	165987867	G	G	165987867	3	3	112	1	0	0	0	0	1	0	0	0	13983	362	13	5	3602	5	SCN3A	2	165987867	Missense_Mutation	SNP	A	TCGA-CQ-7067-01A-11D-2229-08	57365266	165987867	77211506	8	20336											
SCN1A	6323	broad.mit.edu	37	chr2	166900348	166900348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcatccgggatgacctactgGtctgactcaggttgctgttg	6	12	13	10	1	2	2	1	2	1	0	3	3	3	3	2	3	2	4	2	3	1	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr2:166900348G>A	uc010zcz.1	-	11	1892	c.1874C>T	c.(1873-1875)ACC>ATC	p.T625I	SCN1A_uc002udo.3_Missense_Mutation_p.T494I|SCN1A_uc010fpk.2_Missense_Mutation_p.T494I	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	625						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGACCTACTGGTCTGACTCAG	0.532													10	33					0	0	0	0	A	166900348	A	A	166900348	3	1	112	1	0	0	0	0	1	0	0	0	13979	1261	44	4	4219	4	SCN1A	2	166900348	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	912481	166900348	76299025	9	20337											
SCN1A	6323	broad.mit.edu	37	chr2	166911191	166911191	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagccagttccatggatcccGaaggaaagtaaaatcttcta	14	9	9	9	1	2	0	0	0	2	0	4	4	4	2	3	2	1	2	3	2	5	4			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr2:166911191G>A	uc010zcz.1	-	4	577	c.559C>T	c.(559-561)CGG>TGG	p.R187W	SCN1A_uc002udo.3_Missense_Mutation_p.R56W|SCN1A_uc010fpk.2_Missense_Mutation_p.R56W	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	187	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CATGGATCCCGAAGGAAAGTA	0.353													7	33					0	0	0	0	A	166911191	A	A	166911191	3	1	112	1	0	0	0	0	1	0	0	0	13979	1057	37	1	5562	1	SCN1A	2	166911191	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	10843	166911191	76288182	10	20338											
EXOSC7	23016	broad.mit.edu	37	chr3	45017687	45017688	+	5'Flank	INS	-	GG	GG																															atgacgcgctgacgcggggcINSgggggggggtgggacgtggg																										TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr3:45017687_45017688insGG	uc003coi.2	+						ZDHHC3_uc003cod.2_5'Flank|ZDHHC3_uc003cog.2_5'Flank|ZDHHC3_uc011bad.1_5'Flank|EXOSC7_uc003coh.1_Intron|EXOSC7_uc011bae.1_5'Flank|EXOSC7_uc010his.1_5'Flank|EXOSC7_uc003coj.2_5'Flank	NM_015004	NP_055819	Q15024	EXOS7_HUMAN	exosome component 7						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		TGACGCGGGGCGGGGGGGGGTG	0.767													---	---	---								GG	45017688	GG	GG	45017687	6	5	112	0	1	1	1	0	0	0	0	0	5344	783	27	0		0	EXOSC7	3	45017687	5'Flank	INS	-	TCGA-CQ-7067-01A-11D-2229-08		45017687	153004743	11	20339											
FAM194A	131831	broad.mit.edu	37	chr3	150387211	150387211	+	Frame_Shift_Del	DEL	A	-	-																															tttaccttgttgggcactcgAatgatggctaggtttccaga																										TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr3:150387211delA	uc003eyg.2	-	12	1428	c.1371delT	c.(1369-1371)ATTfs	p.I457fs	FAM194A_uc003eyh.2_Frame_Shift_Del_p.I311fs	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	457										skin(2)|ovary(1)	3						TGGGCACTCGAATGATGGCTA	0.408													---	---	---								-	150387211	-	-	150387211	7	5	112	1	0	1	0	1	0	0	0	0	5554	242	9	0	632	0	FAM194A	3	150387211	Frame_Shift_Del	DEL	A	TCGA-CQ-7067-01A-11D-2229-08	105369524	150387211	47635219	12	20340											
PTPN13	5783	broad.mit.edu	37	chr4	87731008	87731008	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaccagatgatctgcttacTtttatctcctacatgagaca	12	13	5	11	0	2	3	0	2	2	2	3	4	2	3	2	0	4	1	2	0	4	4	rs140778130	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr4:87731008T>C	uc003hpz.2	+	46	7650	c.7170T>C	c.(7168-7170)ACT>ACC	p.T2390T	PTPN13_uc003hpy.2_Silent_p.T2395T|PTPN13_uc003hqa.2_Silent_p.T2371T|PTPN13_uc003hqb.2_Silent_p.T2199T	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2390	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		ATCTGCTTACTTTTATCTCCT	0.463													9	54					0	0	0	0	C	87731008	C	C	87731008	2	2	112	1	0	0	0	0	0	0	0	1	12845	1596	56	5		5	PTPN13	4	87731008	Silent	SNP	T	TCGA-CQ-7067-01A-11D-2229-08		87731008	103423268	13	20341											
IRX2	153572	broad.mit.edu	37	chr5	2748946	2748946	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggggctcagcagcggcgcCtccaagccggtaagcggcga	7	3	18	13	5	1	0	1	0	0	0	2	1	2	0	3	6	4	3	3	6	2	1			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr5:2748946C>T	uc003jda.2	-	3	1118	c.876G>A	c.(874-876)GAG>GAA	p.E292E	IRX2_uc003jdb.2_Silent_p.E292E	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	292						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		GCAGCGGCGCCTCCAAGCCGG	0.537													3	13					0	0	0	0	T	2748946	T	T	2748946	2	4	112	1	0	0	0	0	0	0	0	1	7883	680	24	4		4	IRX2	5	2748946	Silent	SNP	C	TCGA-CQ-7067-01A-11D-2229-08		2748946	178166314	14	20342											
HOMER1	9456	broad.mit.edu	37	chr5	78742906	78742906	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtactggtaagttccatcttCtcttgtgatttttcctttgc	5	20	7	9	0	2	1	0	1	2	0	5	1	4	1	2	1	2	3	2	1	2	8			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr5:78742906C>G	uc003kfy.2	-	4	1460	c.357G>C	c.(355-357)GAG>GAC	p.E119D	HOMER1_uc010jab.2_Missense_Mutation_p.E119D|HOMER1_uc010jac.2_Intron|HOMER1_uc010jad.2_Intron	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	119					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		GTTCCATCTTCTCTTGTGATT	0.333													13	27					0	0	0	0	G	78742906	G	G	78742906	3	3	112	1	0	0	0	0	1	0	0	0	7317	912	32	2	731	2	HOMER1	5	78742906	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	75993960	78742906	102172354	15	20343											
GEMIN5	25929	broad.mit.edu	37	chr5	154270961	154270961	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacagttctctgtgagttttGgagactggcatgcttttctg	7	16	11	7	0	2	2	0	1	2	1	3	3	2	2	0	2	2	4	0	2	1	5	rs145603479	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr5:154270961G>C	uc003lvx.3	-	26	4185	c.4102C>G	c.(4102-4104)CAA>GAA	p.Q1368E	GEMIN5_uc011ddk.1_Missense_Mutation_p.Q1367E	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	1368	Potential.				ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGTGAGTTTTGGAGACTGGCA	0.453													13	72					0	0	0	0	C	154270961	C	C	154270961	3	2	112	1	0	0	0	0	1	0	0	0	6368	1357	47	4	436	4	GEMIN5	5	154270961	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	75528055	154270961	26644299	16	20344											
C6orf168	84553	broad.mit.edu	37	chr6	99729296	99729296	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaaaatttcctccttatcCtctcacagtacatggcaagg	11	11	6	13	0	1	0	1	0	1	0	5	0	4	0	4	2	1	2	4	2	5	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr6:99729296C>G	uc003ppj.3	-	6	1257	c.974G>C	c.(973-975)AGG>ACG	p.R325T	C6orf168_uc003ppi.3_Missense_Mutation_p.R45T	NM_032511	NP_115900	Q5TGI0	CF168_HUMAN	hypothetical protein LOC84553	325										ovary(2)|central_nervous_system(1)	3		all_cancers(76;1.63e-06)|Acute lymphoblastic leukemia(125;5.12e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00898)|Colorectal(196;0.0699)|Lung NSC(302;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.073)		CCTCCTTATCCTCTCACAGTA	0.483													61	66					0	0	0	0	G	99729296	G	G	99729296	3	3	112	1	0	0	0	0	1	0	0	0	2353	681	24	4	259	4	C6orf168	6	99729296	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08		99729296	71385771	17	20345											
KIAA1244	57221	broad.mit.edu	37	chr6	138584716	138584716	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagaggaggtggacaccgCtctgcagaactttgcctcta	9	10	12	10	1	2	2	0	0	2	2	2	4	2	4	2	3	3	3	2	3	3	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr6:138584716C>T	uc003qhu.2	+	12	2096	c.2096C>T	c.(2095-2097)GCT>GTT	p.A699V		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	699	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GTGGACACCGCTCTGCAGAAC	0.507													15	73					0	0	0	0	T	138584716	T	T	138584716	3	4	112	1	0	0	0	0	1	0	0	0	8256	797	28	4	2142	4	KIAA1244	6	138584716	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	38855420	138584716	32530351	18	20346											
KBTBD2	25948	broad.mit.edu	37	chr7	32909544	32909544	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtcatcacataaatgcagtCatgaaccacaactgctgcac	14	9	6	12	0	3	1	3	1	0	0	3	1	3	1	1	0	5	3	1	0	4	1			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr7:32909544C>T	uc003tdb.2	-	4	1944	c.1285G>A	c.(1285-1287)GAC>AAC	p.D429N	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	429	Kelch 2.										0			GBM - Glioblastoma multiforme(11;0.0499)			TAAATGCAGTCATGAACCACA	0.463													26	81					0	0	0	0	T	32909544	T	T	32909544	3	4	112	1	0	0	0	0	1	0	0	0	8032	826	29	2	590	2	KBTBD2	7	32909544	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08		32909544	126229119	19	20347											
GPR141	353345	broad.mit.edu	37	chr7	37780629	37780629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgttgatggtgcagaagctaCgccactctttactatcccac	9	12	8	12	1	1	2	0	1	1	1	2	2	2	2	2	1	4	3	2	1	4	5			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr7:37780629C>T	uc003tfm.1	+	1	634	c.634C>T	c.(634-636)CGC>TGC	p.R212C	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	212	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						GCAGAAGCTACGCCACTCTTT	0.413													29	90					0	0	0	0	T	37780629	T	T	37780629	3	4	112	1	0	0	0	0	1	0	0	0	6687	536	19	1	636	1	GPR141	7	37780629	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	4871085	37780629	121358034	20	20348											
GLI3	2737	broad.mit.edu	37	chr7	42262781	42262781	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgctcacatctgttcgagtGgagcacttcactatggaatt	9	13	9	10	2	3	0	2	0	1	0	5	3	3	2	0	2	1	3	0	2	2	4			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr7:42262781G>A	uc011kbh.1	-	2	163	c.72C>T	c.(70-72)TCC>TCT	p.S24S		NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	24					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTGTTCGAGTGGAGCACTTCA	0.502									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				35	108					0	0	0	0	A	42262781	A	A	42262781	2	1	112	1	0	0	0	0	0	0	0	1	6476	1335	47	4		4	GLI3	7	42262781	Silent	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	4482152	42262781	116875882	21	20349											
ABCB4	5244	broad.mit.edu	37	chr7	87051439	87051439	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaatcatgggtacctacctGaaggaagaaagtaaaaaaag	20	6	9	6	0	1	2	1	1	0	1	1	3	1	3	2	2	2	2	2	2	10	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr7:87051439G>A	uc003uiv.1	-	18	2390	c.2314C>T	c.(2314-2316)CAG>TAG	p.Q772*	ABCB4_uc003uiw.1_Nonsense_Mutation_p.Q772*|ABCB4_uc003uix.1_Nonsense_Mutation_p.Q772*	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	772	Helical; (By similarity).|ABC transmembrane type-1 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GTACCTACCTGAAGGAAGAAA	0.323													7	13					0	0	0	0	A	87051439	A	A	87051439	4	1	112	1	0	0	0	0	0	1	0	0	43	1299	45	2	1590	2	ABCB4	7	87051439	Nonsense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	44788658	87051439	72087224	22	20350											
SPAM1	6677	broad.mit.edu	37	chr7	123594394	123594394	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggttgtggaatgaaagcaCtgctctttacccatccattt	9	14	8	10	0	1	1	0	1	1	0	2	2	2	2	2	2	3	3	2	2	3	4			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr7:123594394C>T	uc003vld.2	+	4	1172	c.770C>T	c.(769-771)ACT>ATT	p.T257I	SPAM1_uc003vle.2_Missense_Mutation_p.T257I|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.T257I|SPAM1_uc010lku.2_Missense_Mutation_p.T257I	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	257					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	AATGAAAGCACTGCTCTTTAC	0.413													37	90					0	0	0	0	T	123594394	T	T	123594394	3	4	112	1	0	0	0	0	1	0	0	0	15052	565	20	4	772	4	SPAM1	7	123594394	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	36542955	123594394	35544269	23	20351											
DLC1	10395	broad.mit.edu	37	chr8	12952314	12952314	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagtttgttcgtcattagTggctcaggaagatctcgaaa	11	12	12	6	2	3	2	2	0	1	2	5	5	3	3	0	2	0	3	0	2	3	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr8:12952314T>A	uc003wwm.2	-	12	3924	c.3480A>T	c.(3478-3480)CCA>CCT	p.P1160P	DLC1_uc003wwk.1_Silent_p.P723P|DLC1_uc003wwl.1_Silent_p.P757P|DLC1_uc011kxx.1_Silent_p.P649P	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1160	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TCGTCATTAGTGGCTCAGGAA	0.438													11	38					0	0	0	0	A	12952314	A	A	12952314	2	1	112	1	0	0	0	0	0	0	0	1	4572	1683	59	5		5	DLC1	8	12952314	Silent	SNP	T	TCGA-CQ-7067-01A-11D-2229-08		12952314	133411708	24	20352											
PKHD1L1	93035	broad.mit.edu	37	chr8	110445406	110445406	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagttcagctgtaacagtcTcagttggaccagtaggttgt	9	13	11	8	0	2	0	2	0	1	0	3	1	2	1	1	2	2	6	1	2	3	6			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr8:110445406T>A	uc003yne.2	+	28	3405	c.3301T>A	c.(3301-3303)TCA>ACA	p.S1101T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1101	Extracellular (Potential).|IPT/TIG 4.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGTAACAGTCTCAGTTGGACC	0.348										HNSCC(38;0.096)			79	134					0	0	0	0	A	110445406	A	A	110445406	3	1	112	1	0	0	0	0	1	0	0	0	12027	1551	54	5	3411	5	PKHD1L1	8	110445406	Missense_Mutation	SNP	T	TCGA-CQ-7067-01A-11D-2229-08	97493092	110445406	35918616	25	20353											
MTSS1	9788	broad.mit.edu	37	chr8	125565241	125565241	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttcttgtgaacctaagaaaAgcgaggggctgagcgatcgt	11	10	13	7	3	1	3	0	2	1	1	2	5	1	3	1	2	3	1	1	2	4	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr8:125565241A>C	uc003yrk.2	-	14	2794	c.2260T>G	c.(2260-2262)TTT>GTT	p.F754V	NDUFB9_uc011lim.1_Intron|MTSS1_uc003yrh.2_Missense_Mutation_p.F403V|MTSS1_uc011lin.1_Missense_Mutation_p.F528V|MTSS1_uc011lio.1_Missense_Mutation_p.F644V|MTSS1_uc003yri.2_Missense_Mutation_p.F472V|MTSS1_uc003yrj.2_Missense_Mutation_p.F729V|MTSS1_uc003yrl.2_Missense_Mutation_p.F758V	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	754					actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			ACCTAAGAAAAGCGAGGGGCT	0.453													13	64					0	0	0	0	C	125565241	C	C	125565241	3	2	112	1	0	0	0	0	1	0	0	0	10015	72	3	5	11	5	MTSS1	8	125565241	Missense_Mutation	SNP	A	TCGA-CQ-7067-01A-11D-2229-08	15119835	125565241	20798781	26	20354											
RASEF	158158	broad.mit.edu	37	chr9	85615351	85615351	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctcggagaccacctacctgGggcgagagtgctgagatggg	8	7	16	10	2	1	3	0	1	1	3	2	6	1	3	3	4	2	1	3	4	1	1			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr9:85615351G>A	uc004amo.1	-	11	1833	c.1572C>T	c.(1570-1572)CCC>CCT	p.P524P		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	524					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						CACCTACCTGGGGCGAGAGTG	0.458													15	55					0	0	0	0	A	85615351	A	A	85615351	2	1	112	1	0	0	0	0	0	0	0	1	13133	1219	43	4		4	RASEF	9	85615351	Silent	SNP	G	TCGA-CQ-7067-01A-11D-2229-08		85615351	55598080	27	20355											
C9orf47	286223	broad.mit.edu	37	chr9	91605923	91605923	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaagaaatggtcaggatcTggacaacgataatgatagta	18	8	10	5	1	2	2	1	1	1	1	2	5	2	4	0	3	1	1	0	3	7	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr9:91605923T>C	uc004aqd.2	+	1	146	c.13T>C	c.(13-15)TGG>CGG	p.W5R	S1PR3_uc004aqe.2_5'Flank|C9orf47_uc004aqc.1_Missense_Mutation_p.W5R	NM_001001938	NP_001001938	Q6ZRZ4	CI047_HUMAN	hypothetical protein LOC286223 isoform 1	5						extracellular region					0						GGTCAGGATCTGGACAACGAT	0.552													4	14					0	0	0	0	C	91605923	C	C	91605923	3	2	112	1	0	0	0	0	1	0	0	0	2497	1580	55	5	15	5	C9orf47	9	91605923	Missense_Mutation	SNP	T	TCGA-CQ-7067-01A-11D-2229-08	5990572	91605923	49607508	28	20356											
DBH	1621	broad.mit.edu	37	chr9	136518097	136518097	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcctgcacgtacaacacAgaagaccgggagctggccac	12	4	10	15	2	0	2	0	0	0	2	1	3	1	3	4	2	4	3	4	2	3	1	rs77905	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr9:136518097A>G	uc004cel.2	+	9	1419	c.1410A>G	c.(1408-1410)ACA>ACG	p.T470T		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	470	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding	p.T470T(1)		ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CGTACAACACAGAAGACCGGG	0.612													11	61					0	0	0	0	G	136518097	G	G	136518097	2	3	112	1	0	0	0	0	0	0	0	1	4267	175	7	5		5	DBH	9	136518097	Silent	SNP	A	TCGA-CQ-7067-01A-11D-2229-08	44912174	136518097	4695334	29	20357											
NAT10	55226	broad.mit.edu	37	chr11	34139988	34139988	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggagctgagggagttgaagGagagcttgcaggacacccag	11	6	17	7	0	0	3	0	2	0	1	0	7	0	6	1	4	3	4	1	4	1	2			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr11:34139988G>A	uc001mvk.2	+	8	962	c.718G>A	c.(718-720)GAG>AAG	p.E240K	NAT10_uc010ren.1_Missense_Mutation_p.E168K	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	240						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				GGAGTTGAAGGAGAGCTTGCA	0.532													8	29					0	0	0	0	A	34139988	A	A	34139988	3	1	112	1	0	0	0	0	1	0	0	0	10227	1175	41	2	744	2	NAT10	11	34139988	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08		34139988	100866528	30	20358											
ACRBP	84519	broad.mit.edu	37	chr12	6753392	6753392	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gctgatcgaatgagctcctgGatgttctccattatcatagg	9	13	10	9	1	2	2	1	2	1	0	5	4	3	3	2	2	1	3	2	2	3	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr12:6753392G>C	uc001qpu.1	-	5	903	c.855C>G	c.(853-855)ATC>ATG	p.I285M	ACRBP_uc010sfg.1_Missense_Mutation_p.I252M	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	285						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						TGAGCTCCTGGATGTTCTCCA	0.438													19	82					0	0	0	0	C	6753392	C	C	6753392	3	2	112	1	0	0	0	0	1	0	0	0	170	1164	41	2	800	2	ACRBP	12	6753392	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08		6753392	127098503	31	20359											
LST-3TM12	338821	broad.mit.edu	37	chr12	21196320	21196320	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggttggagcttggtggctTggtttccttgtgtctggaat	3	17	16	5	0	1	0	0	0	1	0	2	2	2	2	1	6	1	4	1	6	1	5			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr12:21196320T>C	uc010sin.1	+	6	639	c.639T>C	c.(637-639)CTT>CTC	p.L213L	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Silent_p.L260L	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	213						membrane	transporter activity				0						CTTGGTGGCTTGGTTTCCTTG	0.363													23	72					0	0	0	0	C	21196320	C	C	21196320	2	2	112	1	0	0	0	0	0	0	0	1	9116	1799	63	5		5	LST-3TM12	12	21196320	Silent	SNP	T	TCGA-CQ-7067-01A-11D-2229-08	14442928	21196320	112655575	32	20360											
MYO16	23026	broad.mit.edu	37	chr13	109550386	109550386	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtgtgcatcttagaagcctTtggacatgccaagaccacac	11	9	9	12	1	1	2	0	0	1	2	1	3	1	3	3	1	3	1	3	1	3	2			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr13:109550386T>A	uc001vqt.1	+	15	1742	c.1616T>A	c.(1615-1617)TTT>TAT	p.F539Y	MYO16_uc010agk.1_Missense_Mutation_p.F561Y|MYO16_uc001vqu.1_Missense_Mutation_p.F339Y|MYO16_uc010tjh.1_Missense_Mutation_p.F51Y	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	539	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTAGAAGCCTTTGGACATGCC	0.408													28	45					0	0	0	0	A	109550386	A	A	109550386	3	1	112	1	0	0	0	0	1	0	0	0	10117	1841	64	5	1670	5	MYO16	13	109550386	Missense_Mutation	SNP	T	TCGA-CQ-7067-01A-11D-2229-08		109550386	5619492	33	20361											
SERPINA12	145264	broad.mit.edu	37	chr14	94986237	94986245	+	5'Flank	DEL	GGTGGTGAC	-	-																															gtggtgatggaggtggtgatGgtggtgacggaggtggtggt																								rs147168993	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr14:94986237_94986245delGGTGGTGAC	uc001ydj.2	-							NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade						regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		aggtggtgatggtggtgacggaggtggtg	0.072													---	---	---								-	94986245	-	-	94986237	6	5	112	0	1	1	0	1	0	0	0	0	14154	1363	47	0		0	SERPINA12	14	94986237	5'Flank	DEL	GGTGGTGAC	TCGA-CQ-7067-01A-11D-2229-08		94986237	12363303	34	20362											
RYR3	6263	broad.mit.edu	37	chr15	33955106	33955106	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cggcaaggaggctcctgtcaAaggcttgttgcagactcgat	9	9	13	10	2	1	1	1	0	0	1	3	3	2	2	1	4	1	5	1	4	2	2			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr15:33955106A>C	uc001zhi.2	+	35	5445	c.5375A>C	c.(5374-5376)AAA>ACA	p.K1792T	RYR3_uc010bar.2_Missense_Mutation_p.K1792T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1792	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCTCCTGTCAAAGGCTTGTTG	0.547													74	105					0	0	0	0	C	33955106	C	C	33955106	3	2	112	1	0	0	0	0	1	0	0	0	13835	14	1	5	5513	5	RYR3	15	33955106	Missense_Mutation	SNP	A	TCGA-CQ-7067-01A-11D-2229-08		33955106	68576286	35	20363											
C15orf29	79768	broad.mit.edu	37	chr15	34434542	34434542	+	Nonstop_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagtagatgaaatctctcAatgtaactgtaataaataag	17	14	6	4	0	2	2	1	1	1	1	3	2	2	2	0	0	1	3	0	0	9	7			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr15:34434542A>C	uc001zhp.2	-	10	1073	c.913T>G	c.(913-915)TGA>GGA	p.*305G		NM_024713	NP_078989	Q9H079	CO029_HUMAN	hypothetical protein LOC79768	305						nucleolus				ovary(1)	1		all_lung(180;1.86e-06)		all cancers(64;5.49e-18)|GBM - Glioblastoma multiforme(113;8.91e-07)|BRCA - Breast invasive adenocarcinoma(123;0.026)|Lung(196;0.229)		GAAATCTCTCAATGTAACTGT	0.284													6	6					0	0	0	0	C	34434542	C	C	34434542	4	2	112	1	0	0	0	0	0	0	0	0	1795	143	5	5	5	5	C15orf29	15	34434542	Nonstop_Mutation	SNP	A	TCGA-CQ-7067-01A-11D-2229-08	479436	34434542	68096850	36	20364											
SEMA6D	80031	broad.mit.edu	37	chr15	48056383	48056383	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttcagcatccctggttcTgctgtctgtgcatttagcat	5	17	8	11	0	3	0	1	0	2	0	4	0	4	0	1	1	4	5	1	1	1	5			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr15:48056383T>C	uc010bek.2	+	11	1338	c.978T>C	c.(976-978)TCT>TCC	p.S326S	SEMA6D_uc001zvw.2_Silent_p.S326S|SEMA6D_uc001zvx.1_Silent_p.S326S|SEMA6D_uc001zvy.2_Silent_p.S326S|SEMA6D_uc001zvz.2_Silent_p.S326S|SEMA6D_uc001zwa.2_Silent_p.S326S|SEMA6D_uc001zwb.2_Silent_p.S326S|SEMA6D_uc001zwc.2_Silent_p.S326S	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	326	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TCCCTGGTTCTGCTGTCTGTG	0.448													27	39					0	0	0	0	C	48056383	C	C	48056383	2	2	112	1	0	0	0	0	0	0	0	1	14107	1567	55	5		5	SEMA6D	15	48056383	Silent	SNP	T	TCGA-CQ-7067-01A-11D-2229-08	13621841	48056383	54475009	37	20365											
ITPRIPL2	162073	broad.mit.edu	37	chr16	19126861	19126861	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaggagcagaagctgctgAgttggctgcaggaacgggca	10	5	17	9	1	0	2	0	1	0	1	0	4	0	4	1	4	5	7	1	4	2	1			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr16:19126861A>G	uc002dfu.3	+	1	1608	c.1078A>G	c.(1078-1080)AGT>GGT	p.S360G	ITPRIPL2_uc002dft.2_Missense_Mutation_p.S56G	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	360	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						GAAGCTGCTGAGTTGGCTGCA	0.667													20	56					0	0	0	0	G	19126861	G	G	19126861	3	3	112	1	0	0	0	0	1	0	0	0	7964	304	11	5	1080	5	ITPRIPL2	16	19126861	Missense_Mutation	SNP	A	TCGA-CQ-7067-01A-11D-2229-08		19126861	71227892	38	20366											
FUS	2521	broad.mit.edu	37	chr16	31193979	31193979	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attcttcttatggccagagcCagaacagtgagtctttctca	10	13	8	10	0	4	3	1	1	4	2	5	3	4	3	2	1	2	0	2	1	2	4			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr16:31193979C>T	uc002ebf.2	+	3	267	c.184C>T	c.(184-186)CAG>TAG	p.Q62*	FUS_uc002ebe.1_Nonsense_Mutation_p.Q62*|FUS_uc002ebh.2_Nonsense_Mutation_p.Q62*|FUS_uc002ebg.2_5'UTR|FUS_uc002ebi.2_Nonsense_Mutation_p.Q62*|FUS_uc002ebj.2_5'UTR|FUS_uc010vfi.1_Nonsense_Mutation_p.Q62*	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	62	Gln/Gly/Ser/Tyr-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		TGGCCAGAGCCAGAACAGTGA	0.398			T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								23	74					0	0	0	0	T	31193979	T	T	31193979	4	4	112	1	0	0	0	0	0	1	0	0	6134	595	21	4	194	4	FUS	16	31193979	Nonsense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	12067118	31193979	59160774	39	20367											
FANCA	2175	broad.mit.edu	37	chr16	89842188	89842188	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagcagagcaggcctggcagTaggtggagtacagagatggg	11	5	18	7	0	0	2	0	0	0	2	0	4	0	3	1	5	3	5	1	5	2	2			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr16:89842188T>C	uc002fou.1	-	21	1904	c.1862A>G	c.(1861-1863)TAC>TGC	p.Y621C	FANCA_uc010vpn.1_Missense_Mutation_p.Y621C	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	621					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GGCCTGGCAGTAGGTGGAGTA	0.458			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				6	19					0	0	0	0	C	89842188	C	C	89842188	3	2	112	1	0	0	0	0	1	0	0	0	5694	1638	57	5	2597	5	FANCA	16	89842188	Missense_Mutation	SNP	T	TCGA-CQ-7067-01A-11D-2229-08	58648209	89842188	512565	40	20368											
USP6	9098	broad.mit.edu	37	chr17	5041493	5041493	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgatacctgggccatgaacGatgacaccgtgctcaagcat	11	8	10	12	3	1	2	1	2	0	0	2	4	1	2	3	1	4	2	3	1	3	1	rs145087393	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:5041493G>A	uc002gau.1	+	21	3233	c.1003G>A	c.(1003-1005)GAT>AAT	p.D335N	USP6_uc002gav.1_Missense_Mutation_p.D335N|USP6_uc010ckz.1_5'UTR|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	335					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						GGCCATGAACGATGACACCGT	0.577			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								21	80					0	0	0	0	A	5041493	A	A	5041493	3	1	112	1	0	0	0	0	1	0	0	0	17154	1058	37	1	1049	1	USP6	17	5041493	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08		5041493	76153717	41	20369											
TP53	7157	broad.mit.edu	37	chr17	7576852	7576852	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agaggtcccaagacttagtaCctgaagggtgaaatattctc	13	10	10	8	0	1	4	0	2	1	2	3	4	2	4	2	2	1	1	2	2	6	4	rs11575997		TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:7576852C>T	uc002gim.2	-	9	1187	c.993_splice	c.e9+1	p.Q331_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.Q331_splice|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_Splice_Site_p.Q199_splice|TP53_uc010cng.1_Splice_Site_p.Q199_splice|TP53_uc002gii.1_Splice_Site_p.Q199_splice|TP53_uc010cnh.1_Splice_Site_p.Q331_splice|TP53_uc010cni.1_Splice_Site_p.Q331_splice|TP53_uc002gij.2_Splice_Site_p.Q331_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(16)|p.0?(7)|p.I332fs*49(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGACTTAGTACCTGAAGGGTG	0.458		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	43					0	0	0	0	T	7576852	T	T	7576852	5	4	112	1	0	0	0	0	0	0	1	0	16448	521	18	4	288	4	TP53	17	7576852	Splice_Site	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	2535359	7576852	73618358	42	20370											
CDRT15	146822	broad.mit.edu	37	chr17	14140168	14140168	+	5'Flank	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcttgctctcttgagcgaCtcccaccaagtgagctgttt	7	13	8	13	1	2	2	0	2	2	0	4	3	3	2	2	0	3	3	2	0	1	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:14140168C>A	uc010vvu.1	-						CDRT15_uc010coq.2_RNA	NM_001007530	NP_001007531	Q96T59	CDRTF_HUMAN	CMT1A duplicated region transcript 15												0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		TCTTGAGCGACTCCCACCAAG	0.527													11	24					0.000151284	0.000155319	1	0	A	14140168	A	A	14140168	1	1	112	0	1	0	0	0	0	0	0	0	3190	580	20	4		4	CDRT15	17	14140168	5'Flank	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	6563316	14140168	67055042	43	20371											
NF1	4763	broad.mit.edu	37	chr17	29685568	29685568	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atccaaatttgttaaatccaAtccatggaattgtgcagagt	14	13	7	7	0	0	1	0	0	0	1	3	2	3	2	3	1	1	2	3	1	5	3	rs146315101		TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:29685568A>G	uc002hgg.2	+	55	8374	c.8041A>G	c.(8041-8043)ATC>GTC	p.I2681V	NF1_uc002hgh.2_Missense_Mutation_p.I2660V|NF1_uc010cso.2_Missense_Mutation_p.I869V|NF1_uc010wbt.1_Missense_Mutation_p.I159V|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2681					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GTTAAATCCAATCCATGGAAT	0.378			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			9	41					0	0	0	0	G	29685568	G	G	29685568	3	3	112	1	0	0	0	0	1	0	0	0	10410	101	4	5	8320	5	NF1	17	29685568	Missense_Mutation	SNP	A	TCGA-CQ-7067-01A-11D-2229-08	15545400	29685568	51509642	44	20372											
SLFN12L	342615	broad.mit.edu	37	chr17	33806812	33806812	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtacaaactggagctcaaCgtggcaatctgcggaccaga	12	8	11	10	2	2	1	1	0	1	1	2	3	2	3	1	3	5	3	1	3	4	2	rs12451876	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:33806812C>T	uc002hjn.2	-	3	1383	c.504G>A	c.(502-504)ACG>ACA	p.T168T		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						TGGAGCTCAACGTGGCAATCT	0.433													4	8					0	0	0	0	T	33806812	T	T	33806812	2	4	112	1	0	0	0	0	0	0	0	1	14799	523	19	1		1	SLFN12L	17	33806812	Silent	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	4121244	33806812	47388398	45	20373											
HNF1B	6928	broad.mit.edu	37	chr17	36104708	36104708	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggaagaccggcttggtgtcGggctcggccccgctgccagg	4	7	17	13	4	0	1	0	0	0	1	2	2	0	2	4	6	1	3	4	6	1	1			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:36104708G>A	uc002hok.3	-	1	389	c.168C>T	c.(166-168)CCC>CCT	p.P56P	HNF1B_uc010wdi.1_Silent_p.P56P	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	56					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GCTTGGTGTCGGGCTCGGCCC	0.667									Hereditary_Prostate_Cancer				25	35					0	0	0	0	A	36104708	A	A	36104708	2	1	112	1	0	0	0	0	0	0	0	1	7291	1103	39	1		1	HNF1B	17	36104708	Silent	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	2297896	36104708	45090502	46	20374											
STARD3	10948	broad.mit.edu	37	chr17	37814249	37814249	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgacgctggtgtccagtgcAttcctcattgtcaaggtcat	8	12	10	11	2	3	0	3	0	0	0	5	1	5	0	2	2	1	2	2	2	1	2			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:37814249A>G	uc002hsd.2	+	5	523	c.399A>G	c.(397-399)GCA>GCG	p.A133A	STARD3_uc010weg.1_Missense_Mutation_p.H129R|STARD3_uc010weh.1_Intron|STARD3_uc002hse.2_Intron|STARD3_uc010wei.1_Missense_Mutation_p.H129R|STARD3_uc002hsf.2_5'UTR|STARD3_uc002hsg.2_5'UTR	NM_006804	NP_006795	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain	133	Helical; (Potential).|MENTAL.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TGTCCAGTGCATTCCTCATTG	0.592													4	9					0	0	0	0	G	37814249	G	G	37814249	2	3	112	1	0	0	0	0	0	0	0	1	15323	217	8	5		5	STARD3	17	37814249	Silent	SNP	A	TCGA-CQ-7067-01A-11D-2229-08	1709541	37814249	43380961	47	20375											
MUC16	94025	broad.mit.edu	37	chr19	9065802	9065802	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgtatcctcctgggtggagGtaataaacattggtgatgtg	9	14	13	5	0	0	1	0	1	0	0	2	2	2	2	2	4	1	2	2	4	4	5			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:9065802G>T	uc002mkp.2	-	3	21848	c.21644C>A	c.(21643-21645)ACC>AAC	p.T7215N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7217	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGGGTGGAGGTAATAAACAT	0.483													40	129					4.65455e-14	4.97778e-14	1	0	T	9065802	T	T	9065802	3	4	112	1	0	0	0	0	1	0	0	0	10026	1261	44	4	22207	4	MUC16	19	9065802	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08		9065802	50063181	48	20376											
ZNF91	7644	broad.mit.edu	37	chr19	23543330	23543330	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctctccagtatgaattgtCttatgcttagtaagggttga	9	17	9	6	0	2	2	0	2	2	0	4	2	3	2	1	1	1	4	1	1	5	7			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:23543330C>G	uc002nre.2	-	4	2564	c.2451G>C	c.(2449-2451)AAG>AAC	p.K817N	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.K785N	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	817	C2H2-type 24.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TATGAATTGTCTTATGCTTAG	0.408													9	23					0	0	0	0	G	23543330	G	G	23543330	3	3	112	1	0	0	0	0	1	0	0	0	18267	912	32	2	1128	2	ZNF91	19	23543330	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	14477528	23543330	35585653	49	20377											
DMKN	93099	broad.mit.edu	37	chr19	36003975	36003975	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcaccattgtggccaggcaCcccctgccaggagccgcgga	8	4	13	16	2	0	0	0	0	0	0	0	2	0	2	6	4	3	2	6	4	0	1	rs78344601	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:36003975C>A	uc002nzm.3	-	1	586	c.403G>T	c.(403-405)GTG>TTG	p.V135L	DMKN_uc002nzj.2_5'Flank|DMKN_uc002nzk.3_5'Flank|DMKN_uc002nzl.3_5'Flank|DMKN_uc002nzo.3_Missense_Mutation_p.V135L|DMKN_uc002nzn.3_Missense_Mutation_p.V135L|DMKN_uc002nzw.2_5'Flank|DMKN_uc002nzr.2_5'Flank|DMKN_uc002nzp.2_5'Flank|DMKN_uc002nzq.2_5'Flank|DMKN_uc002nzt.2_5'Flank|DMKN_uc002nzs.2_5'Flank|DMKN_uc002nzu.2_5'Flank|DMKN_uc002nzv.2_5'Flank|DMKN_uc010xsv.1_5'Flank|DMKN_uc010xsw.1_5'Flank|DMKN_uc002nzx.3_5'Flank|DMKN_uc002nzy.3_5'Flank|DMKN_uc002nzz.2_5'Flank|DMKN_uc002oac.3_Missense_Mutation_p.V135L|DMKN_uc010eeb.2_Missense_Mutation_p.V135L|DMKN_uc002oaa.3_Missense_Mutation_p.V135L|DMKN_uc002oab.3_Missense_Mutation_p.V135L	NM_033317	NP_201574	Q6E0U4	DMKN_HUMAN	dermokine isoform 2 precursor	135	Gly-rich.					extracellular region				large_intestine(1)|ovary(1)|skin(1)	3	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TGGCCAGGCACCCCCTGCCAG	0.597													13	67					1.90627e-21	2.09689e-21	1	0	A	36003975	A	A	36003975	3	1	112	1	0	0	0	0	1	0	0	0	4604	507	18	4	1408	4	DMKN	19	36003975	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	12460645	36003975	23125008	50	20378											
ARHGEF1	9138	broad.mit.edu	37	chr19	42400458	42400459	+	Frame_Shift_Ins	INS	-	C	C																															ccaccccacaggtgctgacgINScccccctggagctgggggac																										TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:42400458_42400459insC	uc002orx.2	+	13	1133_1134	c.1024_1025insC	c.(1024-1026)GCCfs	p.A342fs	ARHGEF1_uc002orw.1_Frame_Shift_Ins_p.A342fs|ARHGEF1_uc002ory.2_Frame_Shift_Ins_p.A309fs|ARHGEF1_uc002orz.2_Frame_Shift_Ins_p.A180fs|ARHGEF1_uc002osa.2_Frame_Shift_Ins_p.A357fs|ARHGEF1_uc002osb.2_Frame_Shift_Ins_p.A324fs|ARHGEF1_uc002osc.2_Frame_Shift_Ins_p.A36fs|ARHGEF1_uc002osd.2_5'Flank	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	342					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		AGGTGCTGACGCCCCCCTGGAG	0.688													---	---	---								C	42400459	C	C	42400458	7	5	112	1	0	1	1	0	0	0	0	0	893	1087	38	0	1119	0	ARHGEF1	19	42400458	Frame_Shift_Ins	INS	-	TCGA-CQ-7067-01A-11D-2229-08	6396483	42400458	16728525	51	20379											
GPR77	27202	broad.mit.edu	37	chr19	47844786	47844786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattgtggtggggttttttGtctgctgggcaccctaccac	4	14	12	11	0	1	0	0	0	1	0	1	0	1	0	3	4	2	3	3	4	1	5			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:47844786G>A	uc010ela.1	+	2	948	c.730G>A	c.(730-732)GTC>ATC	p.V244I	GPR77_uc002pgk.1_Missense_Mutation_p.V244I	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	244	Helical; Name=6; (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		GGGGTTTTTTGTCTGCTGGGC	0.706													14	30					0	0	0	0	A	47844786	A	A	47844786	3	1	112	1	0	0	0	0	1	0	0	0	6747	1377	48	4	732	4	GPR77	19	47844786	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	5444328	47844786	11284197	52	20380											
ZNF551	90233	broad.mit.edu	37	chr19	58199337	58199337	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttatgaatgtagtgaatgtgGaaagtcttttagccaaagtg	13	14	11	3	0	1	2	0	2	1	0	1	3	1	3	1	1	1	1	1	1	7	4			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:58199337G>A	uc002qpw.3	+	3	1869	c.1646G>A	c.(1645-1647)GGA>GAA	p.G549E	ZNF551_uc002qpv.3_Missense_Mutation_p.G492E|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	565	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AGTGAATGTGGAAAGTCTTTT	0.453													9	45					0	0	0	0	A	58199337	A	A	58199337	3	1	112	1	0	0	0	0	1	0	0	0	18050	1174	41	2	1656	2	ZNF551	19	58199337	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	10354551	58199337	929646	53	20381											
PAK7	57144	broad.mit.edu	37	chr20	9561228	9561228	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcggatttcaaaggcttcAcctcagaatagtaggcctcc	12	10	8	11	1	3	1	3	0	0	1	5	2	4	2	3	3	0	2	3	3	5	4			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr20:9561228A>G	uc002wnl.2	-	5	1099	c.554T>C	c.(553-555)GTG>GCG	p.V185A	PAK7_uc002wnk.2_Missense_Mutation_p.V185A|PAK7_uc002wnj.2_Missense_Mutation_p.V185A|PAK7_uc010gby.1_Missense_Mutation_p.V185A	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	185	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			CAAAGGCTTCACCTCAGAATA	0.463													15	87					0	0	0	0	G	9561228	G	G	9561228	3	3	112	1	0	0	0	0	1	0	0	0	11459	159	6	5	1633	5	PAK7	20	9561228	Missense_Mutation	SNP	A	TCGA-CQ-7067-01A-11D-2229-08		9561228	53464292	54	20382											
ZNF217	7764	broad.mit.edu	37	chr20	52198810	52198810	+	Frame_Shift_Del	DEL	T	-	-																															caagccttgctgcagtttgcTtctggcccccgatttgccat																										TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr20:52198810delT	uc002xwq.3	-	1	827	c.556delA	c.(556-558)AGCfs	p.S186fs	ZNF217_uc010gij.1_Frame_Shift_Del_p.S178fs	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	186					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			TGCAGTTTGCTTCTGGCCCCC	0.498													---	---	---								-	52198810	-	-	52198810	7	5	112	1	0	1	0	1	0	0	0	0	17839	1609	56	0	2606	0	ZNF217	20	52198810	Frame_Shift_Del	DEL	T	TCGA-CQ-7067-01A-11D-2229-08	42637582	52198810	10826710	55	20383											
IL10RB	3588	broad.mit.edu	37	chr21	34655489	34655489	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagttcgagggtttcttcctGatcggaacaaagctggggaa	11	10	13	7	2	1	1	0	1	1	0	4	4	2	3	1	4	2	3	1	4	4	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr21:34655489G>T	uc002yrk.1	+	5	688	c.589G>T	c.(589-591)GAT>TAT	p.D197Y	IL10RB_uc002yrh.1_Missense_Mutation_p.D267Y|IL10RB_uc002yri.1_Missense_Mutation_p.D150Y|IL10RB_uc002yrl.1_Missense_Mutation_p.D199Y	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	197	Fibronectin type-III.|Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						GTTTCTTCCTGATCGGAACAA	0.478													21	40					1.28384e-07	1.35419e-07	1	0	T	34655489	T	T	34655489	3	4	112	1	0	0	0	0	1	0	0	0	7660	1290	45	2	607	2	IL10RB	21	34655489	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08		34655489	13474406	56	20384											
SLC25A1	6576	broad.mit.edu	37	chr22	19164358	19164358	+	Splice_Site	DEL	C	-	-																															ggccctgtgatgcagacacaCctcggtaccagttgcgcagg																										TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr22:19164358delC	uc002zoz.2	-	6	746	c.631_splice	c.e6+1	p.G211_splice	SLC25A1_uc002zoy.2_Splice_Site_p.G108_splice|SLC25A1_uc002zpa.2_Splice_Site_p.G159_splice	NM_005984	NP_005975	P53007	TXTP_HUMAN	solute carrier family 25 (mitochondrial carrier;						gluconeogenesis|long-chain fatty-acyl-CoA biosynthetic process|mitochondrial citrate transport|triglyceride biosynthetic process	integral to membrane|mitochondrial inner membrane	citrate transmembrane transporter activity|protein binding				0	Colorectal(54;0.0993)	all_lung(157;9.94e-09)		Lung(27;0.124)		TGCAGACACACCTCGGTACCA	0.627													---	---	---								-	19164358	-	-	19164358	8	5	112	1	0	1	0	1	0	0	1	0	14535	521	18	0	319	0	SLC25A1	22	19164358	Splice_Site	DEL	C	TCGA-CQ-7067-01A-11D-2229-08		19164358	32140208	57	20385											
MYH9	4627	broad.mit.edu	37	chr22	36708210	36708210	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccacgaagctcttgtcggTggctttggggaaccagcact	7	10	12	12	2	1	0	0	0	1	0	3	2	2	1	2	4	3	3	2	4	2	2			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr22:36708210T>G	uc003apg.2	-	14	1843	c.1612A>C	c.(1612-1614)ACC>CCC	p.T538P	MYH9_uc003aph.1_Missense_Mutation_p.T402P	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	538	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CTCTTGTCGGTGGCTTTGGGG	0.602			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				15	56					0	0	0	0	G	36708210	G	G	36708210	3	3	112	1	0	0	0	0	1	0	0	0	10095	1696	59	5	4382	5	MYH9	22	36708210	Missense_Mutation	SNP	T	TCGA-CQ-7067-01A-11D-2229-08	17543852	36708210	14596356	58	20386											
CDKL5	6792	broad.mit.edu	37	chrX	18622375	18622375	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagatctcagcagaaccGccactcattcatggaaagct	13	7	8	13	1	3	2	3	0	1	2	4	3	3	3	2	1	4	3	2	1	2	1			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:18622375G>A	uc004cym.2	+	12	1584	c.1331G>A	c.(1330-1332)CGC>CAC	p.R444H	CDKL5_uc004cyn.2_Missense_Mutation_p.R444H	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	444			R -> C.		neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					CAGCAGAACCGCCACTCATTC	0.463													66	112					0	0	0	0	A	18622375	A	A	18622375	3	1	112	1	0	0	0	0	1	0	0	0	3172	1087	38	1	1373	1	CDKL5	23	18622375	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08		18622375	136648185	59	20387											
HDAC6	10013	broad.mit.edu	37	chrX	48672857	48672857	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgcccccagtgtcctctatTtctccatccaccgctacgag	6	11	6	18	2	2	0	0	0	2	0	5	1	4	0	6	0	2	1	6	0	2	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:48672857T>G	uc011mmi.1	+	11	912	c.817T>G	c.(817-819)TTC>GTC	p.F273V	HDAC6_uc004dks.1_Missense_Mutation_p.F273V|HDAC6_uc010nig.1_Missense_Mutation_p.F121V|HDAC6_uc004dkt.1_Missense_Mutation_p.F273V|HDAC6_uc011mmj.1_Missense_Mutation_p.F218V|HDAC6_uc011mmk.1_Missense_Mutation_p.F254V|HDAC6_uc004dkv.1_Translation_Start_Site|HDAC6_uc004dkw.1_Translation_Start_Site	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	273	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	TGTCCTCTATTTCTCCATCCA	0.532													74	91					0	0	0	0	G	48672857	G	G	48672857	3	3	112	1	0	0	0	0	1	0	0	0	7050	1841	64	5	855	5	HDAC6	23	48672857	Missense_Mutation	SNP	T	TCGA-CQ-7067-01A-11D-2229-08	30050482	48672857	106597703	60	20388											
GPR173	54328	broad.mit.edu	37	chrX	53105971	53105971	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcgtgccctgcacaaggcTccttactacttcctgctgga	7	10	10	14	1	0	0	0	0	0	0	2	2	2	1	3	2	6	3	3	2	3	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:53105971T>A	uc004dru.2	+	2	426	c.168T>A	c.(166-168)GCT>GCA	p.A56A		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	56	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						TGCACAAGGCTCCTTACTACT	0.592													27	32					0	0	0	0	A	53105971	A	A	53105971	2	1	112	1	0	0	0	0	0	0	0	1	6709	1538	54	5		5	GPR173	23	53105971	Silent	SNP	T	TCGA-CQ-7067-01A-11D-2229-08	4433114	53105971	102164589	61	20389											
FAAH2	158584	broad.mit.edu	37	chrX	57337038	57337038	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttcttaggtttgaggaagcGatgaaggaggctcatgctgt	9	12	14	6	1	2	2	1	2	1	0	2	5	2	4	0	4	2	3	0	4	3	3	rs56161888	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:57337038G>A	uc004dvc.2	+	3	437	c.288G>A	c.(286-288)GCG>GCA	p.A96A		NM_174912	NP_777572	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	96						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3						TTGAGGAAGCGATGAAGGAGG	0.388										HNSCC(52;0.14)			10	11					0	0	0	0	A	57337038	A	A	57337038	2	1	112	1	0	0	0	0	0	0	0	1	5382	1045	37	1		1	FAAH2	23	57337038	Silent	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	4231067	57337038	97933522	62	20390											
ZXDB	158586	broad.mit.edu	37	chrX	57620204	57620204	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggttaaaaggcataaggtgGgccaggatctcttagctcag	11	10	13	7	0	2	0	1	0	1	0	3	1	2	1	1	5	1	3	1	5	4	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:57620204G>T	uc004dvd.2	+	1	1936	c.1723G>T	c.(1723-1725)GGC>TGC	p.G575C		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	575	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						GCATAAGGTGGGCCAGGATCT	0.473													17	98					2.32416e-17	2.52057e-17	1	0	T	57620204	T	T	57620204	3	4	112	1	0	0	0	0	1	0	0	0	18318	1232	43	4	1725	4	ZXDB	23	57620204	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	283166	57620204	97650356	63	20391											
FAM123B	139285	broad.mit.edu	37	chrX	63411090	63411090	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acggaagtccctccagtctgGctcgctgcttgcagtggtgg	5	10	14	12	2	1	0	0	0	1	0	4	1	3	1	2	4	2	4	2	4	1	1			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:63411090G>A	uc004dvo.2	-	2	2350	c.2077C>T	c.(2077-2079)CCA>TCA	p.P693S		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	693					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CTCCAGTCTGGCTCGCTGCTT	0.562													5	15					0	0	0	0	A	63411090	A	A	63411090	3	1	112	1	0	0	0	0	1	0	0	0	5451	1203	42	4	1334	4	FAM123B	23	63411090	Missense_Mutation	SNP	G	TCGA-CQ-7067-01A-11D-2229-08	5790886	63411090	91859470	64	20392											
MED12	9968	broad.mit.edu	37	chrX	70348273	70348275	+	In_Frame_Del	DEL	CTC	-	-																															gcacttgtggtttcaacgatCtcctctgcaatgttgatgtg																										TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:70348273_70348275delCTC	uc004dyy.2	+	23	3536_3538	c.3337_3339delCTC	c.(3337-3339)CTCdel	p.L1114del	MED12_uc011mpq.1_In_Frame_Del_p.L1114del|MED12_uc004dyz.2_In_Frame_Del_p.L1114del|MED12_uc004dza.2_In_Frame_Del_p.L961del|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1114					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TTTCAACGATCTCCTCTGCAATG	0.542													---	---	---								-	70348275	-	-	70348273	7	5	112	1	0	1	0	1	0	0	0	0	9481	913	32	0	3427	0	MED12	23	70348273	In_Frame_Del	DEL	CTC	TCGA-CQ-7067-01A-11D-2229-08	6937183	70348273	84922287	65	20393											
CXorf57	55086	broad.mit.edu	37	chrX	105882883	105882883	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtatatcccccatagcagtgCgactgaaagtgcctcagcat	11	9	9	12	1	1	1	1	1	0	0	2	2	2	1	3	0	4	3	3	0	4	3			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:105882883C>T	uc004emi.3	+	9	1851	c.1700C>T	c.(1699-1701)GCG>GTG	p.A567V	CXorf57_uc004emj.3_Intron	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	567										ovary(1)|lung(1)|breast(1)	3						CATAGCAGTGCGACTGAAAGT	0.418													37	100					0	0	0	0	T	105882883	T	T	105882883	3	4	112	1	0	0	0	0	1	0	0	0	4130	768	27	1	1734	1	CXorf57	23	105882883	Missense_Mutation	SNP	C	TCGA-CQ-7067-01A-11D-2229-08	35534610	105882883	49387677	66	20394											
TNFRSF25	8718	broad.mit.edu	37	chr1	6524760	6524760	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcggccactgctgaacagttCtccagcgccacctgggaggc	7	7	12	15	2	1	1	0	1	1	0	3	2	1	2	4	3	3	2	4	3	1	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:6524760C>G	uc001ane.2	-	4	403	c.315G>C	c.(313-315)GAG>GAC	p.E105D	TNFRSF25_uc001ana.2_Intron|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_5'UTR|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Missense_Mutation_p.E105D|TNFRSF25_uc001ang.2_Missense_Mutation_p.E60D|TNFRSF25_uc001anh.2_Missense_Mutation_p.E105D|TNFRSF25_uc001ani.1_Missense_Mutation_p.E105D	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	105	TNFR-Cys 2.|Extracellular (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CTGAACAGTTCTCCAGCGCCA	0.607													17	24					0	0	0	0	G	6524760	G	G	6524760	3	3	113	1	0	0	0	0	1	0	0	0	16362	912	32	2	997	2	TNFRSF25	1	6524760	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08		6524760	242725861	1	20395											
BAI2	576	broad.mit.edu	37	chr1	32207757	32207757	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttccggctgcgctgttgggtCccattggcacaggacgtgga	5	10	15	11	3	0	0	0	0	0	0	2	2	2	2	2	5	1	4	2	5	0	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:32207757C>T	uc001btn.2	-	8	1668	c.1314G>A	c.(1312-1314)GGG>GGA	p.G438G	BAI2_uc010ogo.1_Silent_p.G80G|BAI2_uc010ogp.1_Silent_p.G371G|BAI2_uc010ogq.1_Silent_p.G438G|BAI2_uc001bto.2_Silent_p.G438G|BAI2_uc001btq.1_Silent_p.G371G|BAI2_uc010ogr.1_Silent_p.G371G	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	438	TSP type-1 3.|Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GCTGTTGGGTCCCATTGGCAC	0.662													18	30					0	0	0	0	T	32207757	T	T	32207757	2	4	113	1	0	0	0	0	0	0	0	1	1301	842	30	2		2	BAI2	1	32207757	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	25682997	32207757	217042864	2	20396											
LEPR	3953	broad.mit.edu	37	chr1	66070790	66070790	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccaaagattgctatttgcaGagtgatggtttttatgaatg	11	15	10	5	0	0	4	0	2	0	2	0	4	0	4	1	1	2	3	1	1	4	6			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:66070790G>C	uc001dci.2	+	11	1675	c.1473G>C	c.(1471-1473)CAG>CAC	p.Q491H	LEPR_uc001dcg.2_Missense_Mutation_p.Q491H|LEPR_uc001dch.2_Missense_Mutation_p.Q491H|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.Q491H|LEPR_uc001dck.2_Missense_Mutation_p.Q491H	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	491	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GCTATTTGCAGAGTGATGGTT	0.368													25	61					0	0	0	0	C	66070790	C	C	66070790	3	2	113	1	0	0	0	0	1	0	0	0	8768	933	33	2	1507	2	LEPR	1	66070790	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	33863033	66070790	183179831	3	20397											
UBL4B	164153	broad.mit.edu	37	chr1	110655410	110655410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctaaaggaggcccaccagcCgcagacccagcccctgtggc	9	3	12	17	1	0	1	0	0	0	1	0	2	0	2	6	3	2	2	6	3	2	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:110655410C>T	uc001dzc.2	+	1	349	c.254C>T	c.(253-255)CCG>CTG	p.P85L		NM_203412	NP_981957	Q8N7F7	UBL4B_HUMAN	ubiquitin-like 4B	85						cytoplasm				ovary(1)	1		all_cancers(81;1.14e-05)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0236)|all cancers(265;0.0823)|Epithelial(280;0.0917)|Colorectal(144;0.109)|LUSC - Lung squamous cell carcinoma(189;0.134)		GCCCACCAGCCGCAGACCCAG	0.577													14	36					0	0	0	0	T	110655410	T	T	110655410	3	4	113	1	0	0	0	0	1	0	0	0	16956	652	23	1	256	1	UBL4B	1	110655410	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	44584620	110655410	138595211	4	20398											
PIP5K1A	8394	broad.mit.edu	37	chr1	151204248	151204248	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgtcctcatgcaagatttCtacgtggttgagagtatctt	9	15	10	7	1	3	2	1	1	2	2	4	4	4	2	1	1	2	3	1	1	3	5			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:151204248C>G	uc001exj.2	+	5	791	c.339C>G	c.(337-339)TTC>TTG	p.F113L	PIP5K1A_uc001exi.2_Missense_Mutation_p.F100L|PIP5K1A_uc010pcu.1_Missense_Mutation_p.F101L|PIP5K1A_uc001exk.2_Missense_Mutation_p.F100L|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	113	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGCAAGATTTCTACGTGGTTG	0.483													27	54					0	0	0	0	G	151204248	G	G	151204248	3	3	113	1	0	0	0	0	1	0	0	0	11994	912	32	2	357	2	PIP5K1A	1	151204248	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	40548838	151204248	98046373	5	20399											
CELF3	11189	broad.mit.edu	37	chr1	151688428	151688428	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactgttcgaagatgggcttCaggtccttctcctccagatg	8	12	10	11	1	2	2	1	0	1	2	6	3	4	2	3	2	1	2	3	2	2	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:151688428C>G	uc001eys.1	-	1	863	c.69G>C	c.(67-69)CTG>CTC	p.L23L	CELF3_uc001eyr.2_Silent_p.L23L|CELF3_uc009wmy.2_Silent_p.L23L|CELF3_uc009wmx.1_Silent_p.L23L|CELF3_uc001eyt.2_5'UTR|CELF3_uc010pdi.1_Silent_p.L23L|C1orf230_uc001eyu.2_Intron	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4	23	RRM 1.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2						AGATGGGCTTCAGGTCCTTCT	0.597													4	28					0	0	0	0	G	151688428	G	G	151688428	2	3	113	1	0	0	0	0	0	0	0	1	3232	813	29	2		2	CELF3	1	151688428	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	484180	151688428	97562193	6	20400											
OR6K2	81448	broad.mit.edu	37	chr1	158669812	158669812	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgaagatgagcatcacagCtgtaataatctccactgcat	14	10	7	10	0	2	3	1	2	1	1	3	3	2	3	1	0	3	4	1	0	3	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:158669812C>T	uc001fsu.1	-	1	631	c.631G>A	c.(631-633)GCT>ACT	p.A211T		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGCATCACAGCTGTAATAATC	0.502													19	42					0	0	0	0	T	158669812	T	T	158669812	3	4	113	1	0	0	0	0	1	0	0	0	11256	797	28	4	347	4	OR6K2	1	158669812	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	6981384	158669812	90580809	7	20401											
CADM3	57863	broad.mit.edu	37	chr1	159162470	159162470	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgagggcgagtacacctgctCaatcttcactatgcctgtgc	8	10	10	13	2	3	0	2	0	1	0	3	2	3	0	2	1	4	2	2	1	3	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:159162470C>G	uc001ftl.2	+	3	474	c.332C>G	c.(331-333)TCA>TGA	p.S111*	CADM3_uc009wsx.1_Nonsense_Mutation_p.S145*|CADM3_uc009wsy.1_Nonsense_Mutation_p.S111*|CADM3_uc001ftk.2_Nonsense_Mutation_p.S145*	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	111	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					TACACCTGCTCAATCTTCACT	0.537													26	45					0	0	0	0	G	159162470	G	G	159162470	4	3	113	1	0	0	0	0	0	1	0	0	2580	838	29	2	448	2	CADM3	1	159162470	Nonsense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	492658	159162470	90088151	8	20402											
HMCN1	83872	broad.mit.edu	37	chr1	185815164	185815164	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttttatcttcacagaaattgGcccagtgacaattaccacag	13	12	6	10	0	2	2	1	1	1	1	2	2	2	2	2	1	1	0	2	1	4	5			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:185815164G>T	uc001grq.1	+	2	504	c.275G>T	c.(274-276)GGC>GTC	p.G92V		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	92	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACAGAAATTGGCCCAGTGACA	0.368													7	35					1.12685e-05	1.18279e-05	1	0	T	185815164	T	T	185815164	3	4	113	1	0	0	0	0	1	0	0	0	7259	1203	42	4	281	4	HMCN1	1	185815164	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	26652694	185815164	63435457	9	20403											
OPTC	26254	broad.mit.edu	37	chr1	203467831	203467831	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcccacctgcctggtctgCgtgtgcctcggttcctctgt	1	13	11	16	2	2	0	0	0	2	0	4	0	3	0	5	2	4	1	5	2	0	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:203467831C>T	uc001gzu.1	+	4	509	c.393C>T	c.(391-393)TGC>TGT	p.C131C		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	131	LRRNT.|Cys-rich.					proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCCTGGTCTGCGTGTGCCTCG	0.582													3	51					0	0	0	0	T	203467831	T	T	203467831	2	4	113	1	0	0	0	0	0	0	0	1	10942	776	27	1		1	OPTC	1	203467831	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	17652667	203467831	45782790	10	20404											
IRF6	3664	broad.mit.edu	37	chr1	209969813	209969813	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaattctctgctcttattgaGagcacagcgcagctgggcct	8	11	11	11	1	2	1	0	1	2	1	3	3	2	1	1	1	4	4	1	1	2	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:209969813G>A	uc001hhq.1	-	4	522	c.259C>T	c.(259-261)CTC>TTC	p.L87F	IRF6_uc010psm.1_5'UTR|IRF6_uc009xct.1_Missense_Mutation_p.L87F	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	87	IRF tryptophan pentad repeat.				cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CTCTTATTGAGAGCACAGCGC	0.527										HNSCC(57;0.16)			18	35					0	0	0	0	A	209969813	A	A	209969813	3	1	113	1	0	0	0	0	1	0	0	0	7873	942	33	2	1168	2	IRF6	1	209969813	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	6501982	209969813	39280808	11	20405											
MRPL55	128308	broad.mit.edu	37	chr1	228295553	228295553	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caggtccggtggccttcacgGtgctctgcctcagccggctg	3	9	14	15	3	3	0	2	0	1	0	4	0	4	0	4	5	3	2	4	5	0	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:228295553G>A	uc001hry.2	-	2	788	c.44C>T	c.(43-45)ACC>ATC	p.T15I	MRPL55_uc001hrz.3_Missense_Mutation_p.T51I|MRPL55_uc009xex.2_Missense_Mutation_p.T15I|MRPL55_uc001hsa.3_Missense_Mutation_p.T15I|MRPL55_uc001hsb.3_Missense_Mutation_p.T15I|MRPL55_uc001hsc.3_Missense_Mutation_p.T15I|MRPL55_uc001hsd.3_Missense_Mutation_p.T15I|MRPL55_uc001hse.3_Missense_Mutation_p.T15I|MRPL55_uc001hsf.3_Missense_Mutation_p.T15I|MRPL55_uc001hsg.3_Missense_Mutation_p.T15I	NM_181465	NP_852130	Q7Z7F7	RM55_HUMAN	mitochondrial ribosomal protein L55 isoform a	15					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			central_nervous_system(1)	1		Prostate(94;0.0405)				GGCCTTCACGGTGCTCTGCCT	0.617													9	26					0	0	0	0	A	228295553	A	A	228295553	3	1	113	1	0	0	0	0	1	0	0	0	9872	1261	44	4	350	4	MRPL55	1	228295553	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	18325740	228295553	20955068	12	20406											
LYST	1130	broad.mit.edu	37	chr1	235973499	235973499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgttctttggttgctaagcGgtcaagtttagctttggggt	5	17	13	6	1	2	0	1	0	1	0	2	0	2	0	0	4	3	5	0	4	3	7			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:235973499G>A	uc001hxj.2	-	5	794	c.619C>T	c.(619-621)CGC>TGC	p.R207C	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.R207C	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	207					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GTTGCTAAGCGGTCAAGTTTA	0.413									Chediak-Higashi_syndrome				5	135					0	0	0	0	A	235973499	A	A	235973499	3	1	113	1	0	0	0	0	1	0	0	0	9179	1116	39	1	10982	1	LYST	1	235973499	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	7677946	235973499	13277122	13	20407											
OR2T33	391195	broad.mit.edu	37	chr1	248436971	248436971	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgtggagccggtggtccCagtgaatcaggagaatcatg	9	8	16	8	2	2	2	2	1	0	1	3	4	3	3	2	4	1	0	2	4	2	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr1:248436971C>A	uc010pzi.1	-	1	146	c.146G>T	c.(145-147)TGG>TTG	p.W49L		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCGGTGGTCCCAGTGAATCAG	0.522													18	49					1.30998e-17	1.43613e-17	1	0	A	248436971	A	A	248436971	3	1	113	1	0	0	0	0	1	0	0	0	11078	595	21	4	819	4	OR2T33	1	248436971	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	12463472	248436971	813650	14	20408											
APOB	338	broad.mit.edu	37	chr2	21233458	21233458	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcttcaggtttctctgtacGttttccagtacaactataat	9	17	6	9	1	2	0	1	0	1	0	4	0	3	0	1	1	4	5	1	1	5	8			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:21233458G>A	uc002red.2	-	26	6410	c.6282C>T	c.(6280-6282)AAC>AAT	p.N2094N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2094	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCTCTGTACGTTTTCCAGTA	0.363													10	40					0	0	0	0	A	21233458	A	A	21233458	2	1	113	1	0	0	0	0	0	0	0	1	785	1136	40	1		1	APOB	2	21233458	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08		21233458	221965915	15	20409											
UBXN2A	165324	broad.mit.edu	37	chr2	24222567	24222567	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccatatcaaagacttcattGaaaaataccaaggatctcaa	18	9	5	9	0	3	2	3	1	1	1	4	3	3	3	2	1	1	0	2	1	7	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:24222567G>A	uc010exy.2	+	8	1078	c.610G>A	c.(610-612)GAA>AAA	p.E204K	UBXN2A_uc002rem.2_RNA|UBXN2A_uc002ren.2_Missense_Mutation_p.E204K|UBXN2A_uc010ykj.1_Missense_Mutation_p.E151K	NM_181713	NP_859064	P68543	UBX2A_HUMAN	UBX domain containing 4	204	UBX.										0						AGACTTCATTGAAAAATACCA	0.363													19	36					0	0	0	0	A	24222567	A	A	24222567	3	1	113	1	0	0	0	0	1	0	0	0	16982	1291	45	2	632	2	UBXN2A	2	24222567	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	2989109	24222567	218976806	16	20410											
DHX57	90957	broad.mit.edu	37	chr2	39065051	39065051	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagattcaccttttcaaaatCcatgatggacattgttttga	13	15	6	7	0	2	3	2	2	0	1	3	4	3	4	2	1	0	1	2	1	3	6			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:39065051C>T	uc002rrf.2	-	13	2563	c.2464G>A	c.(2464-2466)GAT>AAT	p.D822N	DHX57_uc002rrd.3_Missense_Mutation_p.D206N|DHX57_uc002rre.2_Missense_Mutation_p.D255N	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	822							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				TTTTCAAAATCCATGATGGAC	0.358													20	34					0	0	0	0	T	39065051	T	T	39065051	3	4	113	1	0	0	0	0	1	0	0	0	4535	855	30	2	1744	2	DHX57	2	39065051	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	14842484	39065051	204134322	17	20411											
BUB1	699	broad.mit.edu	37	chr2	111419371	111419371	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actggaagacatggcgctctCagttcctgctgggagcctac	8	9	12	12	1	1	1	1	0	1	1	3	3	2	3	2	3	3	3	2	3	2	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:111419371C>T	uc002tgc.2	-	10	1117	c.1005G>A	c.(1003-1005)CTG>CTA	p.L335L	BUB1_uc010yxh.1_Silent_p.L315L|BUB1_uc010fkb.2_Silent_p.L335L|BUB1_uc002tgd.2_Silent_p.L335L	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	335					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATGGCGCTCTCAGTTCCTGCT	0.453													25	48					0	0	0	0	T	111419371	T	T	111419371	2	4	113	1	0	0	0	0	0	0	0	1	1575	813	29	2		2	BUB1	2	111419371	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	72354320	111419371	131780002	18	20412											
IWS1	55677	broad.mit.edu	37	chr2	128262665	128262665	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actttccgaatcactgattcGgggtttgggaagctcttcat	8	14	10	9	2	3	1	2	1	1	0	5	3	4	2	1	3	1	2	1	3	2	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:128262665G>A	uc002ton.2	-	3	1117	c.814C>T	c.(814-816)CGA>TGA	p.R272*	IWS1_uc010yzl.1_RNA|uc002too.1_5'Flank|IWS1_uc010fma.2_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	272	Glu-rich.|2.|3 X approximate tandem repeats.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TCACTGATTCGGGGTTTGGGA	0.522													75	153					0	0	0	0	A	128262665	A	A	128262665	4	1	113	1	0	0	0	0	0	1	0	0	7970	1124	39	1	1693	1	IWS1	2	128262665	Nonsense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	16843294	128262665	114936708	19	20413											
XIRP2	129446	broad.mit.edu	37	chr2	168103818	168103818	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caggttgctgtccagaggaaCaaaaatagtcttcttcagcc	12	10	9	10	0	3	1	1	0	2	1	4	2	4	2	2	2	3	2	2	2	4	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:168103818C>A	uc002udx.2	+	8	5934	c.5916C>A	c.(5914-5916)AAC>AAA	p.N1972K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.N1797K|XIRP2_uc010fpq.2_Missense_Mutation_p.N1750K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1797					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCCAGAGGAACAAAAATAGTC	0.458													13	23					9.05144e-12	9.8501e-12	1	0	A	168103818	A	A	168103818	3	1	113	1	0	0	0	0	1	0	0	0	17498	477	17	4	5946	4	XIRP2	2	168103818	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	39841153	168103818	75095555	20	20414											
TTN	7273	broad.mit.edu	37	chr2	179529198	179529198	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaatgtacctttgacaggtAcaacttcagccctttgggga	11	11	10	9	0	1	2	1	1	0	1	1	3	1	3	2	3	4	2	2	3	4	5			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:179529198A>G	uc010zfk.1	-	13	1255	c.707T>C	c.(706-708)GTA>GCA	p.V236A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGACAGGTACAACTTCAGC	0.403													33	72					0	0	0	0	G	179529198	G	G	179529198	3	3	113	1	0	0	0	0	1	0	0	0	16803	406	14	5		5	TTN	2	179529198	Missense_Mutation	SNP	A	TCGA-CQ-7068-01A-11D-2078-08	11425380	179529198	63670175	21	20415											
TTN	7273	broad.mit.edu	37	chr2	179549471	179549471	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactggtttctttggctcttCtggcacttaaaagataccag	10	14	8	9	0	3	1	0	0	3	1	3	1	3	1	1	3	2	3	1	3	4	5			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:179549471C>T	uc010zfg.1	-	128	29052	c.28828G>A	c.(28828-28830)GAA>AAA	p.E9610K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E6271K|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10537							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGCTCTTCTGGCACTTAA	0.388													12	26					0	0	0	0	T	179549471	T	T	179549471	3	4	113	1	0	0	0	0	1	0	0	0	16803	922	32	2	71897	2	TTN	2	179549471	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	20273	179549471	63649902	22	20416											
CASP8	841	broad.mit.edu	37	chr2	202149659	202149659	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggaccacagtaacatggActgcttcatctgctgtatcc	10	11	8	12	0	2	0	1	0	1	0	3	2	3	2	2	2	3	4	2	2	2	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:202149659A>G	uc002uxr.1	+	9	1132	c.923A>G	c.(922-924)GAC>GGC	p.D308G	CASP8_uc002uxp.1_Missense_Mutation_p.D325G|CASP8_uc002uxq.1_Missense_Mutation_p.D293G|CASP8_uc002uxt.1_Missense_Mutation_p.D367G|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Missense_Mutation_p.D293G|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Missense_Mutation_p.D224G	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	308					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						AGTAACATGGACTGCTTCATC	0.468										HNSCC(4;0.00038)			62	38					0	0	0	0	G	202149659	G	G	202149659	3	3	113	1	0	0	0	0	1	0	0	0	2689	275	10	5	1230	5	CASP8	2	202149659	Missense_Mutation	SNP	A	TCGA-CQ-7068-01A-11D-2078-08	22600188	202149659	41049714	23	20417											
INHA	3623	broad.mit.edu	37	chr2	220439822	220439822	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcggaccagaccacccagTggaggggagagagcccgacg	11	2	15	13	3	0	2	0	0	0	2	1	7	0	5	4	4	1	0	4	4	0	0	rs139608664	byFrequency	TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:220439822T>C	uc002vmk.1	+	2	819	c.675T>C	c.(673-675)AGT>AGC	p.S225S		NM_002191	NP_002182	P05111	INHA_HUMAN	inhibin alpha subunit precursor	225					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GACCACCCAGTGGAGGGGAGA	0.692													26	13					0	0	0	0	C	220439822	C	C	220439822	2	2	113	1	0	0	0	0	0	0	0	1	7779	1693	59	5		5	INHA	2	220439822	Silent	SNP	T	TCGA-CQ-7068-01A-11D-2078-08	18290163	220439822	22759551	24	20418											
ESPNL	339768	broad.mit.edu	37	chr2	239040266	239040266	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcacagcggctggggtccCgctcccagcagggcagcttc	6	5	14	16	2	0	0	0	0	0	0	3	0	2	0	2	4	4	6	2	4	0	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr2:239040266C>G	uc002vxq.3	+	9	3021	c.2911C>G	c.(2911-2913)CGC>GGC	p.R971G	ESPNL_uc010fyw.2_Missense_Mutation_p.R667G	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	971										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GCTGGGGTCCCGCTCCCAGCA	0.652													19	10					0	0	0	0	G	239040266	G	G	239040266	3	3	113	1	0	0	0	0	1	0	0	0	5279	652	23	3	2945	3	ESPNL	2	239040266	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	18600444	239040266	4159107	25	20419											
TTC21A	199223	broad.mit.edu	37	chr3	39178436	39178436	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagttcctgaacaaggcaCgcaaggacagcacttggggc	13	6	12	10	1	0	1	0	1	0	0	1	2	1	2	1	4	2	4	1	4	5	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:39178436C>T	uc003cjc.2	+	24	3340	c.3163C>T	c.(3163-3165)CGC>TGC	p.R1055C	TTC21A_uc003cje.2_Missense_Mutation_p.R1056C|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.R1007C|TTC21A_uc003cjf.2_Missense_Mutation_p.R176C	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	1055	TPR 16.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GAACAAGGCACGCAAGGACAG	0.478													10	58					0	0	0	0	T	39178436	T	T	39178436	3	4	113	1	0	0	0	0	1	0	0	0	16755	536	19	1	3260	1	TTC21A	3	39178436	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08		39178436	158843994	26	20420											
MAP4	4134	broad.mit.edu	37	chr3	47912526	47912526	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaaccacccctgcagcggggGctgtcccactgagagtggtg	7	6	15	13	1	0	1	0	1	0	1	1	3	1	1	4	3	3	2	4	3	1	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:47912526G>A	uc003csb.2	-	13	3162	c.2636C>T	c.(2635-2637)GCC>GTC	p.A879V	MAP4_uc003csc.3_Missense_Mutation_p.A879V|MAP4_uc003crw.2_Missense_Mutation_p.A11V|MAP4_uc003crx.2_Missense_Mutation_p.A139V|MAP4_uc011bbe.1_Missense_Mutation_p.A630V|MAP4_uc003cry.2_Missense_Mutation_p.A614V|MAP4_uc003csa.3_Missense_Mutation_p.A614V|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Missense_Mutation_p.A614V	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	879					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGCAGCGGGGGCTGTCCCACT	0.587													18	41					0	0	0	0	A	47912526	A	A	47912526	3	1	113	1	0	0	0	0	1	0	0	0	9311	1203	42	4	1001	4	MAP4	3	47912526	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	8734090	47912526	150109904	27	20421											
EPHA3	2042	broad.mit.edu	37	chr3	89498433	89498433	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatagcctaccgcaagttcaCgtcagccagcgatgtatgga	11	9	10	11	3	2	0	2	0	0	0	2	2	2	1	3	1	4	3	3	1	5	5			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:89498433C>G	uc003dqy.2	+	14	2630	c.2405C>G	c.(2404-2406)ACG>AGG	p.T802R	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	802	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CGCAAGTTCACGTCAGCCAGC	0.438										TSP Lung(6;0.00050)			25	71					0	0	0	0	G	89498433	G	G	89498433	3	3	113	1	0	0	0	0	1	0	0	0	5192	536	19	3	2485	3	EPHA3	3	89498433	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	41585907	89498433	108523997	28	20422											
GAP43	2596	broad.mit.edu	37	chr3	115395076	115395076	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggggtggagaagaagggaGaaggcaccactactgccgaa	14	4	16	7	1	0	3	0	0	0	3	0	6	0	3	2	5	2	1	2	5	5	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:115395076G>C	uc003ebq.2	+	2	633	c.247G>C	c.(247-249)GAA>CAA	p.E83Q	GAP43_uc003ebr.2_Missense_Mutation_p.E119Q	NM_002045	NP_002036	P17677	NEUM_HUMAN	growth associated protein 43 isoform 2	83					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)		GAAGAAGGGAGAAGGCACCAC	0.562													10	21					0	0	0	0	C	115395076	C	C	115395076	3	2	113	1	0	0	0	0	1	0	0	0	6270	943	33	2	395	2	GAP43	3	115395076	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	25896643	115395076	82627354	29	20423											
DNAJB8	165721	broad.mit.edu	37	chr3	128181438	128181438	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttgccgttcacagtcacCgacttgagctgcccgtcttc	5	12	8	16	3	3	1	2	1	1	0	5	2	4	1	4	0	3	2	4	0	0	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:128181438C>T	uc003ekk.1	-	3	2312	c.651G>A	c.(649-651)TCG>TCA	p.S217S	uc003ekl.1_5'Flank	NM_153330	NP_699161	Q8NHS0	DNJB8_HUMAN	DnaJ homolog, subfamily B, member 8	217					protein folding		heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(114;0.177)		TCACAGTCACCGACTTGAGCT	0.632													28	67					0	0	0	0	T	128181438	T	T	128181438	2	4	113	1	0	0	0	0	0	0	0	1	4648	639	23	1		1	DNAJB8	3	128181438	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	12786362	128181438	69840992	30	20424											
LSG1	55341	broad.mit.edu	37	chr3	194392825	194392825	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgacgatggcttcggctccGctgagtctgatggcgcataa	7	10	14	10	4	1	3	0	3	1	0	3	4	2	3	1	3	0	4	1	3	1	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr3:194392825G>A	uc003fui.2	-	1	382	c.67C>T	c.(67-69)CGG>TGG	p.R23W		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	23					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		CTTCGGCTCCGCTGAGTCTGA	0.597													13	24					0	0	0	0	A	194392825	A	A	194392825	3	1	113	1	0	0	0	0	1	0	0	0	9099	1086	38	1	1965	1	LSG1	3	194392825	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	66211387	194392825	3629605	31	20425											
AFAP1	60312	broad.mit.edu	37	chr4	7795475	7795475	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaatgtagtcatagtgcaGagcctccgggtctgtggacg	9	10	13	9	2	3	1	2	0	1	1	4	2	4	2	2	2	2	2	2	2	3	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:7795475G>A	uc003gkg.1	-	11	1618	c.1345C>T	c.(1345-1347)CTG>TTG	p.L449L	AFAP1_uc011bwk.1_Silent_p.L449L	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	449						actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						TCATAGTGCAGAGCCTCCGGG	0.498													23	74					0	0	0	0	A	7795475	A	A	7795475	2	1	113	1	0	0	0	0	0	0	0	1	353	933	33	2		2	AFAP1	4	7795475	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08		7795475	183358801	32	20426											
SLIT2	9353	broad.mit.edu	37	chr4	20258327	20258327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaataacatcacaagaattaCgaagacagattttgctggtc	17	10	7	7	1	1	3	1	0	0	3	2	4	1	3	0	1	3	1	0	1	6	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:20258327C>T	uc003gpr.1	+	2	416	c.212C>T	c.(211-213)ACG>ATG	p.T71M	SLIT2_uc003gps.1_Missense_Mutation_p.T71M	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	71	LRR 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ACAAGAATTACGAAGACAGAT	0.294													14	28					0	0	0	0	T	20258327	T	T	20258327	3	4	113	1	0	0	0	0	1	0	0	0	14804	536	19	1	218	1	SLIT2	4	20258327	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	12462852	20258327	170895949	33	20427											
PCDH7	5099	broad.mit.edu	37	chr4	30726069	30726069	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcctactgttcagcttcatCcccagtcaccaactgcagga	9	10	7	15	0	3	0	3	0	0	0	4	1	4	1	4	1	5	3	4	1	2	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:30726069C>T	uc003gsk.1	+	1	4033	c.3025C>T	c.(3025-3027)CCC>TCC	p.P1009S	PCDH7_uc011bxw.1_Missense_Mutation_p.P962S|PCDH7_uc011bxx.1_Missense_Mutation_p.P1009S	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	1009	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						TCAGCTTCATCCCCAGTCACC	0.507													13	29					0	0	0	0	T	30726069	T	T	30726069	3	4	113	1	0	0	0	0	1	0	0	0	11570	855	30	2	3027	2	PCDH7	4	30726069	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	10467742	30726069	160428207	34	20428											
GYPA	2993	broad.mit.edu	37	chr4	145035857	145035857	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaacctggattttctatttCaacagaacttaaaggcacgt	13	12	6	10	1	2	1	1	0	1	1	2	2	2	2	2	2	3	1	2	2	6	5			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:145035857C>T	uc003ijo.3	-	6	537	c.421G>A	c.(421-423)GAA>AAA	p.E141K	GYPA_uc003ijn.2_Intron|GYPA_uc011cia.1_RNA|GYPA_uc011cib.1_Missense_Mutation_p.E108K|GYPA_uc003ijp.3_Missense_Mutation_p.E109K|GYPA_uc010ioq.2_Missense_Mutation_p.E128K|GYPA_uc010ior.2_Missense_Mutation_p.E76K|GYPA_uc010ios.1_RNA	NM_002099	NP_002090	P02724	GLPA_HUMAN	glycophorin A precursor	141	Cytoplasmic.				interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)	2	all_hematologic(180;0.15)					TTTTCTATTTCAACAGAACTT	0.353													11	26					0	0	0	0	T	145035857	T	T	145035857	3	4	113	1	0	0	0	0	1	0	0	0	6947	835	29	2	39	2	GYPA	4	145035857	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	114309788	145035857	46118419	35	20429											
TLL1	7092	broad.mit.edu	37	chr4	166929097	166929097	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttatccctggttcttaggtCaagagtacaattttctgaag	10	16	8	7	0	3	2	1	1	2	1	4	2	4	2	1	2	1	2	1	2	6	7			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:166929097C>G	uc003irh.1	+	7	1461	c.814C>G	c.(814-816)CAA>GAA	p.Q272E	TLL1_uc011cjn.1_Missense_Mutation_p.Q272E|TLL1_uc011cjo.1_Missense_Mutation_p.Q96E	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	272	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GTTCTTAGGTCAAGAGTACAA	0.408													17	39					0	0	0	0	G	166929097	G	G	166929097	3	3	113	1	0	0	0	0	1	0	0	0	16011	827	29	2	840	2	TLL1	4	166929097	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	21893240	166929097	24225179	36	20430											
FAM149A	25854	broad.mit.edu	37	chr4	187086549	187086549	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggttcaaacgtcacggagCaggttccccccgctagtcac	8	8	10	15	3	3	0	3	0	0	0	4	1	4	1	3	3	2	4	3	3	2	3	rs34360147		TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr4:187086549C>A	uc003iyt.3	+	11	1674	c.1095C>A	c.(1093-1095)AGC>AGA	p.S365R	FAM149A_uc011cla.1_Missense_Mutation_p.S365R|FAM149A_uc003iyu.3_Missense_Mutation_p.S365R|FAM149A_uc010isl.2_Missense_Mutation_p.S365R|FAM149A_uc011clb.1_Missense_Mutation_p.S365R	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	656										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		CGTCACGGAGCAGGTTCCCCC	0.542													10	33					6.40141e-05	6.62524e-05	1	0	A	187086549	A	A	187086549	3	1	113	1	0	0	0	0	1	0	0	0	5483	709	25	4	1125	4	FAM149A	4	187086549	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	20157452	187086549	4067727	37	20431											
ADCY2	108	broad.mit.edu	37	chr5	7773108	7773108	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttcctgcgggtaaactatGagctgaagatgttgatcatg	10	13	12	6	1	1	4	1	3	0	1	2	4	2	4	1	1	3	4	1	1	4	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr5:7773108G>C	uc003jdz.1	+	18	2345	c.2278G>C	c.(2278-2280)GAG>CAG	p.E760Q	ADCY2_uc011cmo.1_Missense_Mutation_p.E580Q	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	760					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGTAAACTATGAGCTGAAGAT	0.502													30	75					0	0	0	0	C	7773108	C	C	7773108	3	2	113	1	0	0	0	0	1	0	0	0	294	1291	45	2	2348	2	ADCY2	5	7773108	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08		7773108	173142152	38	20432											
GPBP1	65056	broad.mit.edu	37	chr5	56546873	56546873	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaaatgaaattcctcaagaGaatggcaatgcctcagtgat	16	9	9	7	0	2	3	2	2	0	1	3	5	3	3	2	1	1	1	2	1	6	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr5:56546873G>C	uc003jrh.3	+	10	2339	c.1065G>C	c.(1063-1065)GAG>GAC	p.E355D	GPBP1_uc010iwg.2_Missense_Mutation_p.E375D|GPBP1_uc003jri.3_Missense_Mutation_p.E184D|GPBP1_uc003jrj.3_Missense_Mutation_p.E347D|GPBP1_uc003jrk.3_Missense_Mutation_p.E362D|GPBP1_uc003jrl.3_RNA	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		TTCCTCAAGAGAATGGCAATG	0.398													12	38					0	0	0	0	C	56546873	C	C	56546873	3	2	113	1	0	0	0	0	1	0	0	0	6633	933	33	2	1120	2	GPBP1	5	56546873	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	48773765	56546873	124368387	39	20433											
CTNNA1	1495	broad.mit.edu	37	chr5	138260216	138260216	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagagaatcacattttggaaGatgtgaacaaatgtgtcatt	15	12	9	5	0	2	3	2	1	0	2	2	5	2	4	0	1	1	0	0	1	4	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr5:138260216G>C	uc003ldh.2	+	12	1659	c.1564G>C	c.(1564-1566)GAT>CAT	p.D522H	CTNNA1_uc011cyx.1_Missense_Mutation_p.D419H|CTNNA1_uc011cyy.1_Missense_Mutation_p.D399H|CTNNA1_uc003ldi.2_Missense_Mutation_p.D220H|CTNNA1_uc003ldj.2_Missense_Mutation_p.D522H|CTNNA1_uc003ldl.2_Missense_Mutation_p.D152H	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	522					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CATTTTGGAAGATGTGAACAA	0.463													5	17					0	0	0	0	C	138260216	C	C	138260216	3	2	113	1	0	0	0	0	1	0	0	0	4029	942	33	2	1606	2	CTNNA1	5	138260216	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	81713343	138260216	42655044	40	20434											
SLC36A2	153201	broad.mit.edu	37	chr5	150723750	150723750	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctcttaccaggatgcccgcGttcttcacagcgaggggtag	7	10	12	12	3	3	0	1	0	2	0	4	2	3	1	2	3	3	2	2	3	2	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr5:150723750G>A	uc003lty.2	-	2	373	c.243C>T	c.(241-243)AAC>AAT	p.N81N	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Translation_Start_Site|SLC36A2_uc010jhv.2_Silent_p.N81N|SLC36A2_uc011dct.1_Silent_p.N81N	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	81	Extracellular (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGATGCCCGCGTTCTTCACAG	0.547													5	17					0	0	0	0	A	150723750	A	A	150723750	2	1	113	1	0	0	0	0	0	0	0	1	14658	1136	40	1		1	SLC36A2	5	150723750	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	12463534	150723750	30191510	41	20435											
TRIM27	5987	broad.mit.edu	37	chr6	28871933	28871933	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catggggcagatgatcagagGagctgcacttttccctcccg	8	9	12	12	1	1	3	1	1	0	2	3	4	3	4	2	3	2	3	2	3	0	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr6:28871933G>A	uc003nlr.2	-	8	1815	c.1456C>T	c.(1456-1458)CCT>TCT	p.P486S	TRIM27_uc003nls.2_3'UTR|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	486	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						ATGATCAGAGGAGCTGCACTT	0.522			T	RET	papillary thyroid								22	69					0	0	0	0	A	28871933	A	A	28871933	3	1	113	1	0	0	0	0	1	0	0	0	16568	1174	41	2	89	2	TRIM27	6	28871933	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08		28871933	142243134	42	20436											
TRERF1	55809	broad.mit.edu	37	chr6	42224469	42224469	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttcatggttccttaccatCacatcacctttggcctcaaa	9	15	4	13	0	4	0	4	0	0	0	5	0	5	0	4	2	1	1	4	2	2	5			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr6:42224469C>T	uc003osd.2	-	12	3140	c.2577G>A	c.(2575-2577)GTG>GTA	p.V859V	TRERF1_uc011duq.1_Silent_p.V776V|TRERF1_uc003osb.2_Silent_p.V615V|TRERF1_uc003osc.2_Silent_p.V615V|TRERF1_uc003ose.2_Silent_p.V879V	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	859	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TCCTTACCATCACATCACCTT	0.403													14	37					0	0	0	0	T	42224469	T	T	42224469	2	4	113	1	0	0	0	0	0	0	0	1	16542	813	29	2		2	TRERF1	6	42224469	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	13352536	42224469	128890598	43	20437											
RIMS1	22999	broad.mit.edu	37	chr6	72889449	72889449	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaaagcacgactccaagagCgatcgcggtctcagacaccc	13	4	10	14	4	1	3	1	0	1	3	4	5	2	3	2	1	2	1	2	1	2	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr6:72889449C>T	uc003pga.2	+	5	720	c.643C>T	c.(643-645)CGA>TGA	p.R215*	RIMS1_uc011dyb.1_5'Flank|RIMS1_uc003pgc.2_5'Flank|RIMS1_uc003pgb.3_5'Flank	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	215					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				ACTCCAAGAGCGATCGCGGTC	0.587													12	40					0	0	0	0	T	72889449	T	T	72889449	4	4	113	1	0	0	0	0	0	1	0	0	13432	760	27	1	661	1	RIMS1	6	72889449	Nonsense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	30664980	72889449	98225618	44	20438											
BEND3	57673	broad.mit.edu	37	chr6	107390676	107390676	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcaccagcaggcgcgaggcGaagttgccgatggacaggct	9	5	16	11	4	0	0	0	0	0	0	0	4	0	1	2	4	3	4	2	4	1	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr6:107390676G>A	uc003prs.2	-	5	2369	c.1719C>T	c.(1717-1719)TTC>TTT	p.F573F		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	573	BEN 3.									ovary(3)	3						GGCGCGAGGCGAAGTTGCCGA	0.637													27	40					0	0	0	0	A	107390676	A	A	107390676	2	1	113	1	0	0	0	0	0	0	0	1	1401	1049	37	1		1	BEND3	6	107390676	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	34501227	107390676	63724391	45	20439											
MAP7	9053	broad.mit.edu	37	chr6	136687111	136687111	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgggtggcaaggaggatgtCggtctgggtgtgccaggcaa	7	7	19	8	2	1	0	0	0	1	0	2	2	1	2	2	7	1	2	2	7	2	0	rs143331676	byFrequency	TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr6:136687111C>T	uc003qgz.2	-	10	1281	c.1035G>A	c.(1033-1035)CCG>CCA	p.P345P	MAP7_uc011edf.1_Silent_p.P330P|MAP7_uc011edg.1_Silent_p.P375P|MAP7_uc010kgu.2_Silent_p.P367P|MAP7_uc011edh.1_Silent_p.P330P|MAP7_uc010kgv.2_Silent_p.P367P|MAP7_uc010kgs.2_Silent_p.P199P|MAP7_uc011edi.1_Silent_p.P199P|MAP7_uc010kgq.1_Silent_p.P251P|MAP7_uc003qha.1_Silent_p.P308P|MAP7_uc010kgr.2_Silent_p.P199P	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	345	Pro-rich.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		AGGAGGATGTCGGTCTGGGTG	0.592													15	42					0	0	0	0	T	136687111	T	T	136687111	2	4	113	1	0	0	0	0	0	0	0	1	9319	871	31	1		1	MAP7	6	136687111	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	29296435	136687111	34427956	46	20440											
GTF2IRD2	84163	broad.mit.edu	37	chr7	74239555	74239556	+	In_Frame_Ins	INS	-	TAC	TAC																															ttcacagggcagggaggtttINScacctcacacagtccctctg																										TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr7:74239555_74239556insTAC	uc003ubd.1	-	4	448_449	c.264_265insGTA	c.(262-267)insGTA	p.88_89insV	GTF2IRD2_uc011kfi.1_In_Frame_Ins_p.88_89insV|GTF2IRD2_uc003ubf.1_In_Frame_Ins_p.88_89insV|GTF2IRD2_uc003ubg.1_In_Frame_Ins_p.88_89insV	NM_173537	NP_775808	Q86UP8	GTD2A_HUMAN	GTF2I repeat domain containing 2	88_89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAGGGAGGTTTCACCTCACACA	0.485													---	---	---								TAC	74239556	TAC	TAC	74239555	7	5	113	1	0	1	1	0	0	0	0	0	6908	1792	62	0	2636	0	GTF2IRD2	7	74239555	In_Frame_Ins	INS	-	TCGA-CQ-7068-01A-11D-2078-08		74239555	84899108	47	20441											
HBP1	26959	broad.mit.edu	37	chr7	106826299	106826299	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtttacattcctatgcacGccctccaccagtgtcctctt	8	13	5	15	1	1	0	0	0	1	0	4	0	4	0	5	0	2	2	5	0	3	5	rs151293151	by1000genomes	TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr7:106826299G>A	uc003vdy.2	+	4	638	c.452G>A	c.(451-453)CGC>CAC	p.R151H	HBP1_uc011klv.1_Missense_Mutation_p.R161H|HBP1_uc003vdz.2_Missense_Mutation_p.R151H|HBP1_uc003vea.2_Missense_Mutation_p.R151H|HBP1_uc003veb.1_Missense_Mutation_p.R151H	NM_012257	NP_036389	O60381	HBP1_HUMAN	HMG-box transcription factor 1	151					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			skin(1)	1						TCCTATGCACGCCCTCCACCA	0.423													39	61					0	0	0	0	A	106826299	A	A	106826299	3	1	113	1	0	0	0	0	1	0	0	0	7024	1087	38	1	462	1	HBP1	7	106826299	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	32586744	106826299	52312364	48	20442											
NOS3	4846	broad.mit.edu	37	chr7	150695737	150695737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagcaggatggctctgtgcGgggggacccagccaacgtgg	7	5	18	11	2	1	0	0	0	1	0	1	2	1	2	2	6	4	3	2	6	1	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr7:150695737G>A	uc003wif.2	+	7	1081	c.785G>A	c.(784-786)CGG>CAG	p.R262Q	NOS3_uc011kuy.1_Missense_Mutation_p.R56Q|NOS3_uc011kuz.1_Missense_Mutation_p.R262Q|NOS3_uc011kva.1_Missense_Mutation_p.R262Q|NOS3_uc011kvb.1_Missense_Mutation_p.R262Q	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	262	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GGCTCTGTGCGGGGGGACCCA	0.652													3	8					0	0	0	0	A	150695737	A	A	150695737	3	1	113	1	0	0	0	0	1	0	0	0	10598	1116	39	1	807	1	NOS3	7	150695737	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	43869438	150695737	8442926	49	20443											
SHH	6469	broad.mit.edu	37	chr7	155599120	155599120	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgtggtgatgtccactgcGcggccctcgtagtgcagaga	7	8	15	11	4	0	2	0	1	0	1	2	4	1	2	2	2	2	2	2	2	1	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr7:155599120G>A	uc003wmk.1	-	2	583	c.432C>T	c.(430-432)CGC>CGT	p.R144R	SHH_uc003wmh.1_RNA|SHH_uc003wmi.1_Silent_p.R57R|SHH_uc003wmj.1_Silent_p.R57R	NM_000193	NP_000184	Q15465	SHH_HUMAN	sonic hedgehog preproprotein	144			R -> P (in HPE3).		androgen metabolic process|axon guidance|branching involved in ureteric bud morphogenesis|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|embryonic digit morphogenesis|hindbrain development|intein-mediated protein splicing|lymphoid progenitor cell differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|midbrain development|negative regulation of cell migration|negative regulation of kidney smooth muscle cell differentiation|negative regulation of ureter smooth muscle cell differentiation|negative thymic T cell selection|neural crest cell migration|neuroblast proliferation|patterning of blood vessels|positive regulation of alpha-beta T cell differentiation|positive regulation of immature T cell proliferation in thymus|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of T cell differentiation in thymus|positive regulation of ureter smooth muscle cell differentiation|positive thymic T cell selection|proteolysis|sclerotome development|stem cell development|thymus development|vasculogenesis|ventral midline development	cell surface|extracellular space|membrane raft|plasma membrane	calcium ion binding|laminin-1 binding|peptidase activity|signal transducer activity|zinc ion binding			central_nervous_system(3)|lung(1)	4	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00882)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGTCCACTGCGCGGCCCTCGT	0.642													13	18					0	0	0	0	A	155599120	A	A	155599120	2	1	113	1	0	0	0	0	0	0	0	1	14344	1074	38	1		1	SHH	7	155599120	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	4903383	155599120	3539543	50	20444											
TNKS	8658	broad.mit.edu	37	chr8	9564372	9564372	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcagtttactccactgcacGaggctgcttccaagaaccgt	9	9	10	13	2	0	1	0	0	0	1	2	2	2	1	3	2	4	5	3	2	3	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:9564372G>A	uc003wss.2	+	8	1326	c.1321G>A	c.(1321-1323)GAG>AAG	p.E441K	TNKS_uc011kwv.1_Missense_Mutation_p.E441K|TNKS_uc011kww.1_Missense_Mutation_p.E204K	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	441	ANK 6.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		TCCACTGCACGAGGCTGCTTC	0.438													20	66					0	0	0	0	A	9564372	A	A	9564372	3	1	113	1	0	0	0	0	1	0	0	0	16385	1059	37	1	1351	1	TNKS	8	9564372	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08		9564372	136799650	51	20445											
SLC26A7	115111	broad.mit.edu	37	chr8	92350418	92350418	+	Frame_Shift_Del	DEL	A	-	-																															ttgttattgcaccaatatggAaaacacatatggattagaag																										TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:92350418delA	uc003yex.2	+	8	1114	c.836delA	c.(835-837)GAAfs	p.E279fs	SLC26A7_uc003yey.2_Intron|SLC26A7_uc003yez.2_Frame_Shift_Del_p.E279fs|SLC26A7_uc003yfa.2_Frame_Shift_Del_p.E279fs	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	279	Cytoplasmic (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			ACCAATATGGAAAACACATAT	0.303													---	---	---								-	92350418	-	-	92350418	7	5	113	1	0	1	0	1	0	0	0	0	14586	246	9	0	858	0	SLC26A7	8	92350418	Frame_Shift_Del	DEL	A	TCGA-CQ-7068-01A-11D-2078-08	82786046	92350418	54013604	52	20446											
DPYS	1807	broad.mit.edu	37	chr8	105393527	105393527	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atagggtgcacgctccacagGggtaggtgtgcaagtctgaa	10	8	15	8	1	1	1	0	1	1	0	2	1	2	1	1	4	2	4	1	4	4	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:105393527G>C	uc003yly.3	-	9	1588	c.1459C>G	c.(1459-1461)CCT>GCT	p.P487A	DPYS_uc010mcf.1_Missense_Mutation_p.P57A	NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	487					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CGCTCCACAGGGGTAGGTGTG	0.473													13	53					0	0	0	0	C	105393527	C	C	105393527	3	2	113	1	0	0	0	0	1	0	0	0	4768	1232	43	4	104	4	DPYS	8	105393527	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	13043109	105393527	40970495	53	20447											
EXT1	2131	broad.mit.edu	37	chr8	119123160	119123160	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggtggtgcaagccattcctAccgctgtgttcttctctccg	4	13	11	13	2	2	0	0	0	2	0	5	0	4	0	4	2	3	3	4	2	2	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:119123160A>T	uc003yok.1	-	1	899	c.126T>A	c.(124-126)GGT>GGA	p.G42G		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	42	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			AGCCATTCCTACCGCTGTGTT	0.562			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				7	30					0	0	0	0	T	119123160	T	T	119123160	2	4	113	1	0	0	0	0	0	0	0	1	5348	378	14	5		5	EXT1	8	119123160	Silent	SNP	A	TCGA-CQ-7068-01A-11D-2078-08	13729633	119123160	27240862	54	20448											
FAM135B	51059	broad.mit.edu	37	chr8	139268962	139268962	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccgtaaagtgcagatccAccttgagttgaaaatctact	12	12	8	9	1	1	3	0	2	1	1	3	3	3	3	3	0	2	3	3	0	5	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:139268962A>G	uc003yuy.2	-	5	509	c.338T>C	c.(337-339)GTG>GCG	p.V113A	FAM135B_uc003yux.2_Missense_Mutation_p.V14A|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	113										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTGCAGATCCACCTTGAGTTG	0.438										HNSCC(54;0.14)			3	25					0	0	0	0	G	139268962	G	G	139268962	3	3	113	1	0	0	0	0	1	0	0	0	5477	159	6	5	3946	5	FAM135B	8	139268962	Missense_Mutation	SNP	A	TCGA-CQ-7068-01A-11D-2078-08	20145802	139268962	7095060	55	20449											
TRAPPC9	83696	broad.mit.edu	37	chr8	141370156	141370156	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagctcactcaccctgatcCgacaagaagtccagcatggt	11	8	9	13	1	2	3	2	2	0	1	4	4	4	3	3	1	2	2	3	1	2	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:141370156C>G	uc003yvj.2	-	9	1622	c.1488G>C	c.(1486-1488)TCG>TCC	p.S496S	TRAPPC9_uc003yvh.2_Silent_p.S594S|TRAPPC9_uc003yvi.1_Silent_p.S487S	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	496					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						CACCCTGATCCGACAAGAAGT	0.498													18	64					0	0	0	0	G	141370156	G	G	141370156	2	3	113	1	0	0	0	0	0	0	0	1	16532	639	23	3		3	TRAPPC9	8	141370156	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	2101194	141370156	4993866	56	20450											
PLEC	5339	broad.mit.edu	37	chr8	144992793	144992793	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccttcaccgggtccagcagGaagcctgtggctgcctgtgc	5	8	13	15	1	1	0	1	0	0	0	2	1	2	1	5	3	4	2	5	3	1	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr8:144992793G>A	uc003zaf.1	-	32	11777	c.11607C>T	c.(11605-11607)TTC>TTT	p.F3869F	PLEC_uc003zab.1_Silent_p.F3732F|PLEC_uc003zac.1_Silent_p.F3736F|PLEC_uc003zad.2_Silent_p.F3732F|PLEC_uc003zae.1_Silent_p.F3700F|PLEC_uc003zag.1_Silent_p.F3710F|PLEC_uc003zah.2_Silent_p.F3718F|PLEC_uc003zaj.2_Silent_p.F3759F	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3869	Globular 2.|Plectin 18.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GGTCCAGCAGGAAGCCTGTGG	0.672													10	33					0	0	0	0	A	144992793	A	A	144992793	2	1	113	1	0	0	0	0	0	0	0	1	12107	1165	41	2		2	PLEC	8	144992793	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	3622637	144992793	1371229	57	20451											
TLN1	7094	broad.mit.edu	37	chr9	35720835	35720835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggatgatatcgatgtagcCggcaatgagctgtgcaatct	11	10	12	8	2	1	2	0	2	1	0	2	4	1	3	1	2	3	4	1	2	4	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:35720835C>T	uc003zxt.2	-	11	1534	c.1180G>A	c.(1180-1182)GGC>AGC	p.G394S		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	394	FERM.|Interaction with LAYN (By similarity).				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCGATGTAGCCGGCAATGAGC	0.512													9	95					0	0	0	0	T	35720835	T	T	35720835	3	4	113	1	0	0	0	0	1	0	0	0	16013	652	23	1	6633	1	TLN1	9	35720835	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08		35720835	105492596	58	20452											
FLJ46321	389763	broad.mit.edu	37	chr9	84605930	84605930	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctcagcaacccctccagAagacctaatactgtcccctc	10	7	4	20	0	1	2	1	0	0	2	4	2	3	2	8	0	3	1	8	0	4	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:84605930A>T	uc004amn.2	+	4	592	c.545A>T	c.(544-546)GAA>GTA	p.E182V		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	182	Pro-rich.					integral to membrane					0						ACCCCTCCAGAAGACCTAATA	0.547													20	59					0	0	0	0	T	84605930	T	T	84605930	3	4	113	1	0	0	0	0	1	0	0	0	5964	246	9	5	559	5	FLJ46321	9	84605930	Missense_Mutation	SNP	A	TCGA-CQ-7068-01A-11D-2078-08	48885095	84605930	56607501	59	20453											
FBP1	2203	broad.mit.edu	37	chr9	97369181	97369181	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgttaaggctgtagattttAcctttcttttttatcttcac	7	21	5	8	1	3	1	1	0	2	1	4	1	3	1	1	1	1	3	1	1	4	9			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:97369181A>G	uc004auw.3	-	5	952	c.621T>C	c.(619-621)GGT>GGC	p.G207G	FBP1_uc010mrl.2_Silent_p.G207G	NM_000507	NP_000498	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	207					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	TGTAGATTTTACCTTTCTTTT	0.512													39	45					0	0	0	0	G	97369181	G	G	97369181	2	3	113	1	0	0	0	0	0	0	0	1	5737	378	14	5		5	FBP1	9	97369181	Silent	SNP	A	TCGA-CQ-7068-01A-11D-2078-08	12763251	97369181	43844250	60	20454											
KIAA1529	57653	broad.mit.edu	37	chr9	100071844	100071844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcagaagtggatgcacaGcctccccaacgactggatca	13	5	10	13	1	1	1	1	0	0	1	2	4	2	3	3	2	4	2	3	2	2	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:100071844G>A	uc011lut.1	+	15	1540	c.767G>A	c.(766-768)AGC>AAC	p.S256N	KIAA1529_uc004axe.1_Missense_Mutation_p.S256N|KIAA1529_uc004axg.1_Missense_Mutation_p.S117N|KIAA1529_uc011lus.1_Missense_Mutation_p.S117N|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.S117N|KIAA1529_uc011luv.1_Missense_Mutation_p.S117N	NM_020893	NP_065944			hypothetical protein LOC57653									p.S256R(1)		ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TGGATGCACAGCCTCCCCAAC	0.547													13	38					0	0	0	0	A	100071844	A	A	100071844	3	1	113	1	0	0	0	0	1	0	0	0	8279	971	34	4	789	4	KIAA1529	9	100071844	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	2702663	100071844	41141587	61	20455											
ZBTB43	23099	broad.mit.edu	37	chr9	129596134	129596134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttccaccggcatgtgacttCttgtactaagtcctacgaag	9	13	8	11	2	1	1	0	1	1	0	3	2	3	1	3	1	2	2	3	1	4	6			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:129596134C>T	uc004bql.2	+	3	1619	c.1346C>T	c.(1345-1347)TCT>TTT	p.S449F	ZBTB43_uc010mxf.2_Missense_Mutation_p.S449F	NM_014007	NP_054726	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	449	C2H2-type 3; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATGTGACTTCTTGTACTAAG	0.443													37	127					0	0	0	0	T	129596134	T	T	129596134	3	4	113	1	0	0	0	0	1	0	0	0	17611	913	32	2	1348	2	ZBTB43	9	129596134	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	29524290	129596134	11617297	62	20456											
PMPCA	23203	broad.mit.edu	37	chr9	139311437	139311437	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaacacagttggcctccaccGtttctgccccacagaaaacg	11	7	8	15	2	1	1	0	0	1	1	2	2	2	1	5	1	3	2	5	1	3	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:139311437G>A	uc004chl.2	+	7	673	c.668G>A	c.(667-669)CGT>CAT	p.R223H	PMPCA_uc010nbl.2_Missense_Mutation_p.R123H|PMPCA_uc011mdz.1_Missense_Mutation_p.R92H|PMPCA_uc004chm.1_5'UTR|PMPCA_uc004chn.1_5'Flank	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	223					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		GGCCTCCACCGTTTCTGCCCC	0.562													7	32					0	0	0	0	A	139311437	A	A	139311437	3	1	113	1	0	0	0	0	1	0	0	0	12195	1145	40	1	694	1	PMPCA	9	139311437	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	9715303	139311437	1901994	63	20457											
ABCA2	20	broad.mit.edu	37	chr9	139912245	139912245	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccggcccgcgcacctccttGagccggtgctccttctccgc	2	8	10	21	5	1	1	0	1	1	0	4	1	3	1	7	2	2	2	7	2	0	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr9:139912245G>C	uc011mem.1	-	15	2350	c.2202C>G	c.(2200-2202)CTC>CTG	p.L734L	ABCA2_uc011mel.1_Silent_p.L735L|ABCA2_uc004ckl.1_Silent_p.L665L|ABCA2_uc004ckm.1_Silent_p.L765L|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	734					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCACCTCCTTGAGCCGGTGCT	0.692													5	15					0	0	0	0	C	139912245	C	C	139912245	2	2	113	1	0	0	0	0	0	0	0	1	32	1277	45	2		2	ABCA2	9	139912245	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	600808	139912245	1301186	64	20458											
ITIH5	80760	broad.mit.edu	37	chr10	7618752	7618752	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttccctgccttctgaggccGcacaggcacatctgtcttca	6	12	8	15	1	4	1	1	1	3	0	5	1	5	1	3	2	1	2	3	2	0	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:7618752G>A	uc001ijq.2	-	10	1721	c.1642C>T	c.(1642-1644)CGG>TGG	p.R548W	ITIH5_uc001ijp.2_Missense_Mutation_p.R334W|ITIH5_uc001ijr.1_Missense_Mutation_p.R548W	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	548					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TTCTGAGGCCGCACAGGCACA	0.587													3	29					0	0	0	0	A	7618752	A	A	7618752	3	1	113	1	0	0	0	0	1	0	0	0	7946	1086	38	1	1329	1	ITIH5	10	7618752	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08		7618752	127915995	65	20459											
KIAA1217	56243	broad.mit.edu	37	chr10	24834871	24834871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaagcagttctctgccctCttctagtggtgacagctcta	9	12	9	11	0	4	1	0	1	4	0	5	2	4	1	1	1	3	3	1	1	4	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:24834871C>T	uc001iru.3	+	21	5853	c.5450C>T	c.(5449-5451)TCT>TTT	p.S1817F	KIAA1217_uc001irs.2_Missense_Mutation_p.S1138F|KIAA1217_uc001irt.3_Missense_Mutation_p.S1183F|KIAA1217_uc010qcy.1_Missense_Mutation_p.S1248F|KIAA1217_uc010qcz.1_Missense_Mutation_p.S1223F|KIAA1217_uc001irw.2_3'UTR|KIAA1217_uc001irz.2_3'UTR|KIAA1217_uc001irx.2_3'UTR|KIAA1217_uc001iry.2_3'UTR	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1817	Ser-rich.				embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						TCTCTGCCCTCTTCTAGTGGT	0.512													43	91					0	0	0	0	T	24834871	T	T	24834871	3	4	113	1	0	0	0	0	1	0	0	0	8255	913	32	2	5532	2	KIAA1217	10	24834871	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	17216119	24834871	110699876	66	20460											
ARID5B	84159	broad.mit.edu	37	chr10	63759861	63759861	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tttgtctaggggaggacgagGaagaaacgaacgtgatagtt	13	9	15	4	3	1	2	0	1	1	1	1	7	1	5	0	4	2	1	0	4	5	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:63759861G>A	uc001jlt.1	+	4	540	c.514G>A	c.(514-516)GAA>AAA	p.E172K	ARID5B_uc010qil.1_Missense_Mutation_p.E172K	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	172					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GGAGGACGAGGAAGAAACGAA	0.473													8	22					0	0	0	0	A	63759861	A	A	63759861	3	1	113	1	0	0	0	0	1	0	0	0	922	1175	41	2	528	2	ARID5B	10	63759861	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	38924990	63759861	71774886	67	20461											
ANKRD1	27063	broad.mit.edu	37	chr10	92678707	92678707	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagagcagccttcagaaacGtaggcacatccacaggttcc	12	6	9	14	1	1	2	1	0	0	2	3	2	3	2	4	2	3	4	4	2	2	3	rs145387010		TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:92678707G>A	uc001khe.1	-	4	616	c.368C>T	c.(367-369)ACG>ATG	p.T123M		NM_014391	NP_055206	Q15327	ANKR1_HUMAN	cardiac ankyrin repeat protein	123					cellular lipid metabolic process|defense response|signal transduction		DNA binding				0		Colorectal(252;0.0475)				CTTCAGAAACGTAGGCACATC	0.368													8	35					0	0	0	0	A	92678707	A	A	92678707	3	1	113	1	0	0	0	0	1	0	0	0	637	1145	40	1	615	1	ANKRD1	10	92678707	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	28918846	92678707	42856040	68	20462											
MGEA5	10724	broad.mit.edu	37	chr10	103569963	103569963	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccaatttacgtttcaatGtggatacttccttggggtta	8	16	10	7	1	1	0	1	0	0	0	3	1	3	1	2	4	2	2	2	4	5	7			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:103569963G>A	uc001ktv.2	-	4	901	c.458C>T	c.(457-459)ACA>ATA	p.T153I	MGEA5_uc010qqe.1_Missense_Mutation_p.T153I|MGEA5_uc009xws.2_Missense_Mutation_p.T153I|MGEA5_uc001ktw.2_Missense_Mutation_p.T153I|MGEA5_uc009xwt.2_Intron|MGEA5_uc010qqf.1_RNA	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	153					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		ACGTTTCAATGTGGATACTTC	0.373													5	63					0	0	0	0	A	103569963	A	A	103569963	3	1	113	1	0	0	0	0	1	0	0	0	9608	1377	48	4	2344	4	MGEA5	10	103569963	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	10891256	103569963	31964784	69	20463											
TRIM8	81603	broad.mit.edu	37	chr10	104416918	104416918	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcggccaccagccctaccCccgctccggccactttccct	4	7	8	22	3	0	0	0	0	0	0	2	0	2	0	8	3	2	1	8	3	1	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr10:104416918C>T	uc001kvz.2	+	6	1586	c.1463C>T	c.(1462-1464)CCC>CTC	p.P488L		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	488						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CAGCCCTACCCCCGCTCCGGC	0.657													10	26					0	0	0	0	T	104416918	T	T	104416918	3	4	113	1	0	0	0	0	1	0	0	0	16615	623	22	4	1485	4	TRIM8	10	104416918	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	846955	104416918	31117829	70	20464											
HRAS	3265	broad.mit.edu	37	chr11	534285	534285	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcagcgcactcttgcccacaCcgccggcgcccaccaccacc	7	4	7	23	4	2	0	1	0	1	0	2	0	2	0	7	1	2	1	7	1	0	1	rs104894226		TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:534285C>A	uc001lpv.2	-	2	226	c.38G>T	c.(37-39)GGT>GTT	p.G13V	HRAS_uc010qvw.1_Missense_Mutation_p.G13V|HRAS_uc010qvx.1_Missense_Mutation_p.G13V|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	13	GTP.		G -> D (in FCSS).|G -> C (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(33)|p.G13V(10)|p.G13D(9)|p.G13S(9)|p.G13C(6)|p.G13G(1)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CTTGCCCACACCGCCGGCGCC	0.642		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			10	14					4.68919e-08	4.99281e-08	1	0	A	534285	A	A	534285	3	1	113	1	0	0	0	0	1	0	0	0	7387	507	18	4	614	4	HRAS	11	534285	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08		534285	134472231	71	20465											
MUC2	4583	broad.mit.edu	37	chr11	1093601	1093601	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgcaaccccaacacccaccgGcacacagaccccaaccatga	14	1	5	21	2	0	2	0	1	0	1	0	2	0	2	7	1	3	2	7	1	3	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:1093601G>A	uc001lsx.1	+	31	12533	c.12506G>A	c.(12505-12507)GGC>GAC	p.G4169D		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4169						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ACACCCACCGGCACACAGACC	0.408													3	23					0	0	0	0	A	1093601	A	A	1093601	3	1	113	1	0	0	0	0	1	0	0	0	10028	1203	42	4	5538	4	MUC2	11	1093601	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	559316	1093601	133912915	72	20466											
OR51I1	390063	broad.mit.edu	37	chr11	5462199	5462199	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	actttcatgagatctggatgGagacagtaggagtgatgcaa	13	10	13	5	0	2	3	1	2	1	2	2	7	2	5	0	3	1	2	0	3	2	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:5462199G>C	uc010qze.1	-	1	546	c.546C>G	c.(544-546)CTC>CTG	p.L182L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATCTGGATGGAGACAGTAGG	0.433													14	22					0	0	0	0	C	5462199	C	C	5462199	2	2	113	1	0	0	0	0	0	0	0	1	11154	1161	41	2		2	OR51I1	11	5462199	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	4368598	5462199	129544317	73	20467											
OR6A2	8590	broad.mit.edu	37	chr11	6816910	6816910	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagcaacacaaactcactCactctcccactatggttccg	11	8	4	18	1	3	0	2	0	1	0	5	0	4	0	3	1	3	2	3	1	3	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:6816910C>G	uc001mes.1	-	1	230	c.30G>C	c.(28-30)GTG>GTC	p.V10V		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAAACTCACTCACTCTCCCAC	0.512													13	41					0	0	0	0	G	6816910	G	G	6816910	2	3	113	1	0	0	0	0	0	0	0	1	11240	813	29	2		2	OR6A2	11	6816910	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	1354711	6816910	128189606	74	20468											
OR10A2	341276	broad.mit.edu	37	chr11	6891679	6891679	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctacatgttcctcacacCtccttgttgtctctcttttc	4	20	3	14	0	4	0	1	0	3	0	8	0	6	0	3	0	1	2	3	0	1	7			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:6891679C>T	uc001meu.1	+	1	694	c.694C>T	c.(694-696)CTC>TTC	p.L232F		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	232	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TTCCTCACACCTCCTTGTTGT	0.423													109	46					0	0	0	0	T	6891679	T	T	6891679	3	4	113	1	0	0	0	0	1	0	0	0	10944	681	24	4	696	4	OR10A2	11	6891679	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	74769	6891679	128114837	75	20469											
ZNF215	7762	broad.mit.edu	37	chr11	6977464	6977464	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggagattcttcaaccgacGtacaaaccttactaagcatc	13	10	7	11	2	2	1	1	0	1	1	3	3	2	1	2	1	5	2	2	1	5	5	rs139686178		TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:6977464G>A	uc001mey.2	+	7	1844	c.1256G>A	c.(1255-1257)CGT>CAT	p.R419H	ZNF215_uc010raw.1_3'UTR|ZNF215_uc010rax.1_Missense_Mutation_p.R181H|ZNF215_uc001mez.1_Intron	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	419	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		TTCAACCGACGTACAAACCTT	0.408													20	30					0	0	0	0	A	6977464	A	A	6977464	3	1	113	1	0	0	0	0	1	0	0	0	17838	1145	40	1	1274	1	ZNF215	11	6977464	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	85785	6977464	128029052	76	20470											
ABCC8	6833	broad.mit.edu	37	chr11	17428294	17428294	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcccaggctgcagagcacCgtgaacaccatggcatagac	12	5	11	13	1	0	3	0	1	0	2	0	3	0	3	3	2	4	4	3	2	2	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:17428294C>T	uc001mnc.2	-	26	3330	c.3204G>A	c.(3202-3204)ACG>ACA	p.T1068T		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1068	ABC transmembrane type-1 2.|Extracellular (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGCAGAGCACCGTGAACACCA	0.602													28	18					0	0	0	0	T	17428294	T	T	17428294	2	4	113	1	0	0	0	0	0	0	0	1	58	639	23	1		1	ABCC8	11	17428294	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	10450830	17428294	117578222	77	20471											
CHST1	8534	broad.mit.edu	37	chr11	45671567	45671567	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agggttccgagccaggtcctCgtagcgcaccaacatgtact	9	8	11	13	3	0	0	0	0	0	0	3	1	2	0	4	2	4	4	4	2	3	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:45671567C>T	uc001mys.1	-	4	1578	c.907G>A	c.(907-909)GAG>AAG	p.E303K		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	303	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		GCCAGGTCCTCGTAGCGCACC	0.627													35	23					0	0	0	0	T	45671567	T	T	45671567	3	4	113	1	0	0	0	0	1	0	0	0	3412	893	31	1	332	1	CHST1	11	45671567	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	28243273	45671567	89334949	78	20472											
OR5T1	390155	broad.mit.edu	37	chr11	56043262	56043262	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttagcaatctatctattcActctaataggcaatttaggg	12	16	6	7	0	4	0	1	0	3	0	4	0	4	0	0	2	1	2	0	2	8	9			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:56043262A>G	uc001nio.1	+	1	148	c.148A>G	c.(148-150)ACT>GCT	p.T50A		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	50	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					CTATCTATTCACTCTAATAGG	0.338													19	49					0	0	0	0	G	56043262	G	G	56043262	3	3	113	1	0	0	0	0	1	0	0	0	11235	159	6	5	150	5	OR5T1	11	56043262	Missense_Mutation	SNP	A	TCGA-CQ-7068-01A-11D-2078-08	10371695	56043262	78963254	79	20473											
PC	5091	broad.mit.edu	37	chr11	66618354	66618354	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcccggagggagctgaccAgcatggtgcaggccgtgggc	6	5	19	11	2	0	1	0	1	0	0	1	3	1	3	3	6	3	3	3	6	0	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:66618354A>G	uc001ojn.1	-	16	2313	c.2264T>C	c.(2263-2265)CTG>CCG	p.L755P	PC_uc001ojo.1_Missense_Mutation_p.L755P|PC_uc001ojp.1_Missense_Mutation_p.L755P|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	755	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GGAGCTGACCAGCATGGTGCA	0.662													7	13					0	0	0	0	G	66618354	G	G	66618354	3	3	113	1	0	0	0	0	1	0	0	0	11551	188	7	5	1296	5	PC	11	66618354	Missense_Mutation	SNP	A	TCGA-CQ-7068-01A-11D-2078-08	10575092	66618354	68388162	80	20474											
ZBTB16	7704	broad.mit.edu	37	chr11	113934865	113934865	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaggcaaagaggggcctggGaccccgactcgaagcagcgt	11	3	16	11	3	0	2	0	0	0	2	1	5	0	3	3	4	2	2	3	4	2	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr11:113934865G>T	uc001pop.2	+	2	1107	c.843G>T	c.(841-843)GGG>GGT	p.G281G	ZBTB16_uc001poo.1_Silent_p.G281G|ZBTB16_uc001poq.2_Silent_p.G281G	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	281					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		AGGGGCCTGGGACCCCGACTC	0.647													7	21					0.000274275	0.00027995	1	0	T	113934865	T	T	113934865	2	4	113	1	0	0	0	0	0	0	0	1	17593	1161	41	2		2	ZBTB16	11	113934865	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	47316511	113934865	21071651	81	20475											
KRT78	196374	broad.mit.edu	37	chr12	53238435	53238435	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agtgatgatgctgctgaagtCcaggtagcggttgttgtcca	8	12	14	7	1	0	3	0	3	0	0	2	3	2	3	2	2	3	5	2	2	2	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr12:53238435C>G	uc001sbc.1	-	5	893	c.829G>C	c.(829-831)GAC>CAC	p.D277H		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	277	Linker 12.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						CTGCTGAAGTCCAGGTAGCGG	0.627													23	39					0	0	0	0	G	53238435	G	G	53238435	3	3	113	1	0	0	0	0	1	0	0	0	8530	855	30	2	753	2	KRT78	12	53238435	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08		53238435	80613460	82	20476											
C12orf51	283450	broad.mit.edu	37	chr12	112602002	112602002	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgcagcagggcttgttgggGctgtcagggctctccgtggc	3	10	17	11	1	2	0	1	0	1	0	3	0	2	0	1	5	2	6	1	5	0	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr12:112602002G>A	uc009zwc.2	-	66	11364	c.11346C>T	c.(11344-11346)AGC>AGT	p.S3782S		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GCTTGTTGGGGCTGTCAGGGC	0.652													16	33					0	0	0	0	A	112602002	A	A	112602002	2	1	113	1	0	0	0	0	0	0	0	1	1702	1194	42	4		4	C12orf51	12	112602002	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	59363567	112602002	21249893	83	20477											
FBXO21	23014	broad.mit.edu	37	chr12	117595803	117595803	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctctagagtgtgctgcacCaggtagcccaccgccccgtg	6	8	12	15	2	1	1	0	0	1	1	1	1	1	1	5	1	4	4	5	1	2	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr12:117595803C>A	uc001twk.2	-	10	1452	c.1413G>T	c.(1411-1413)CTG>CTT	p.L471L	FBXO21_uc001twj.2_Silent_p.L464L|FBXO21_uc009zwq.2_Silent_p.L404L|FBXO21_uc001twl.1_Silent_p.L84L	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	471					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		TGTGCTGCACCAGGTAGCCCA	0.532													61	166					1.08141e-31	1.19439e-31	1	0	A	117595803	A	A	117595803	2	1	113	1	0	0	0	0	0	0	0	1	5765	581	21	4		4	FBXO21	12	117595803	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	4993801	117595803	16256092	84	20478											
ATP12A	479	broad.mit.edu	37	chr13	25266965	25266965	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctaggacttgggcctccttAtccaagataataacattgtg	11	13	8	9	0	1	1	0	0	1	1	3	2	3	2	3	2	1	0	3	2	5	6			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr13:25266965A>G	uc001upp.2	+	10	1495	c.1308A>G	c.(1306-1308)TTA>TTG	p.L436L	ATP12A_uc010aaa.2_Silent_p.L442L	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	436	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GGGCCTCCTTATCCAAGATAA	0.483													57	147					0	0	0	0	G	25266965	G	G	25266965	2	3	113	1	0	0	0	0	0	0	0	1	1124	446	16	5		5	ATP12A	13	25266965	Silent	SNP	A	TCGA-CQ-7068-01A-11D-2078-08		25266965	89902913	85	20479											
MTUS2	23281	broad.mit.edu	37	chr13	29855999	29855999	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaaatccacttccacacccGctggtaagactttgtgcctt	10	11	6	14	1	0	1	0	0	0	1	2	1	2	1	4	1	1	2	4	1	3	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr13:29855999G>A	uc001usl.3	+	4	2891	c.2833G>A	c.(2833-2835)GCT>ACT	p.A945T		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	935	Localization to the growing distal tip of microtubules.|Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TTCCACACCCGCTGGTAAGAC	0.542													16	43					0	0	0	0	A	29855999	A	A	29855999	3	1	113	1	0	0	0	0	1	0	0	0	10019	1087	38	1	2847	1	MTUS2	13	29855999	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	4589034	29855999	85313879	86	20480											
SLITRK1	114798	broad.mit.edu	37	chr13	84453669	84453669	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagggaattaatctcggaCgcggaggagttggcatctcg	9	10	15	7	4	2	0	0	0	2	0	4	4	2	4	0	5	0	3	0	5	3	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr13:84453669C>T	uc001vlk.2	-	1	2860	c.1974G>A	c.(1972-1974)GCG>GCA	p.A658A		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	658	Cytoplasmic (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TAATCTCGGACGCGGAGGAGT	0.552													9	20					0	0	0	0	T	84453669	T	T	84453669	2	4	113	1	0	0	0	0	0	0	0	1	14806	523	19	1		1	SLITRK1	13	84453669	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	54597670	84453669	30716209	87	20481											
SLITRK5	26050	broad.mit.edu	37	chr13	88329806	88329806	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgtgtacggcggcggcggCggcacgggcggccacccaca	6	2	18	15	8	0	0	0	0	0	0	0	0	0	0	2	7	2	2	2	7	1	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr13:88329806C>T	uc001vln.2	+	2	2382	c.2163C>T	c.(2161-2163)GGC>GGT	p.G721G	SLITRK5_uc010tic.1_Silent_p.G480G	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	721	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCGGCGGCGGCGGCACGGGCG	0.652													16	33					0	0	0	0	T	88329806	T	T	88329806	2	4	113	1	0	0	0	0	0	0	0	1	14810	755	27	1		1	SLITRK5	13	88329806	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	3876137	88329806	26840072	88	20482											
NAA30	122830	broad.mit.edu	37	chr14	57857726	57857726	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcccaccaccagcaccTccggccccggcggcggtcga	5	4	10	22	5	0	0	0	0	0	0	4	1	3	0	8	4	1	1	8	4	0	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr14:57857726T>G	uc001xcx.3	+	2	205	c.51T>G	c.(49-51)CCT>CCG	p.P17P	NAA30_uc010trk.1_Intron|NAA30_uc010aow.2_Intron	NM_001011713	NP_001011713	Q147X3	NAA30_HUMAN	N-acetyltransferase 12	17	Pro-rich.					cytoplasm	peptide alpha-N-acetyltransferase activity			skin(1)	1						CACCAGCACCTCCGGCCCCGG	0.721													4	10					0	0	0	0	G	57857726	G	G	57857726	2	3	113	1	0	0	0	0	0	0	0	1	10175	1538	54	5		5	NAA30	14	57857726	Silent	SNP	T	TCGA-CQ-7068-01A-11D-2078-08		57857726	49491814	89	20483											
CPSF2	53981	broad.mit.edu	37	chr14	92628079	92628079	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttatatgaacaatatgcCattgtataaaggacatgatg	15	14	7	5	0	0	2	0	2	0	0	0	3	0	3	1	1	2	1	1	1	8	7			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr14:92628079C>T	uc001yah.1	+	16	2577	c.2340C>T	c.(2338-2340)GCC>GCT	p.A780A		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	780					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		AACAATATGCCATTGTATAAA	0.338													4	18					0	0	0	0	T	92628079	T	T	92628079	2	4	113	1	0	0	0	0	0	0	0	1	3840	581	21	4		4	CPSF2	14	92628079	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	34770353	92628079	14721461	90	20484											
ATP8B4	79895	broad.mit.edu	37	chr15	50190329	50190329	+	Frame_Shift_Del	DEL	C	-	-																															gtaacagcatttctgtacttCttcaccagctctaccacttg																										TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr15:50190329delC	uc001zxu.2	-	22	2551	c.2409delG	c.(2407-2409)AAGfs	p.K803fs	ATP8B4_uc010ber.2_Frame_Shift_Del_p.K676fs|ATP8B4_uc010ufd.1_Frame_Shift_Del_p.K613fs|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxv.1_Frame_Shift_Del_p.K101fs	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	803	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTCTGTACTTCTTCACCAGCT	0.433													---	---	---								-	50190329	-	-	50190329	7	5	113	1	0	1	0	1	0	0	0	0	1199	912	32	0	1197	0	ATP8B4	15	50190329	Frame_Shift_Del	DEL	C	TCGA-CQ-7068-01A-11D-2078-08		50190329	52341063	91	20485											
CGNL1	84952	broad.mit.edu	37	chr15	57731561	57731561	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggagcagcgcacggggcttCatgtgcccactccaggcctc	6	6	14	15	2	1	0	1	0	0	0	3	1	2	1	3	4	3	3	3	4	0	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr15:57731561C>T	uc002aeg.2	+	2	1440	c.1364C>T	c.(1363-1365)TCA>TTA	p.S455L	CGNL1_uc010bfw.2_Missense_Mutation_p.S455L	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	455	Head.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		CACGGGGCTTCATGTGCCCAC	0.622													13	23					0	0	0	0	T	57731561	T	T	57731561	3	4	113	1	0	0	0	0	1	0	0	0	3319	838	29	2	1366	2	CGNL1	15	57731561	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	7541232	57731561	44799831	92	20486											
KIAA0101	9768	broad.mit.edu	37	chr15	64669065	64669065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgccacttgggagttgggCgcacgcaaacggggttccct	6	10	14	11	3	0	0	0	0	0	0	1	1	1	1	2	4	2	4	2	4	1	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr15:64669065C>T	uc002ank.2	-	3	299	c.167G>A	c.(166-168)CGC>CAC	p.R56H	KIAA0101_uc002anl.2_Intron	NM_014736	NP_055551	Q15004	PAF_HUMAN	hypothetical protein LOC9768 isoform 1	56						mitochondrion|nucleus				central_nervous_system(1)	1						GGGAGTTGGGCGCACGCAAAC	0.393													13	28					0	0	0	0	T	64669065	T	T	64669065	3	4	113	1	0	0	0	0	1	0	0	0	8194	768	27	1	201	1	KIAA0101	15	64669065	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	6937504	64669065	37862327	93	20487											
KIAA1199	57214	broad.mit.edu	37	chr15	81181917	81181917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggaaaaatatgcaatcGtcccattgatatacaggtac	15	9	7	10	1	0	1	0	1	0	0	2	2	1	2	2	2	3	2	2	2	7	5			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr15:81181917G>A	uc002bfw.1	+	9	1330	c.1070G>A	c.(1069-1071)CGT>CAT	p.R357H	KIAA1199_uc010unn.1_Missense_Mutation_p.R357H	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	357										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						ATATGCAATCGTCCCATTGAT	0.348													13	41					0	0	0	0	A	81181917	A	A	81181917	3	1	113	1	0	0	0	0	1	0	0	0	8252	1145	40	1	1100	1	KIAA1199	15	81181917	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	16512852	81181917	21349475	94	20488											
IFT140	9742	broad.mit.edu	37	chr16	1657244	1657244	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcatccggggcttctatCtggtggtcataatagagggc	7	11	14	9	1	3	1	1	0	2	1	4	1	4	1	1	5	1	3	1	5	3	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:1657244C>A	uc002cmb.2	-	3	386	c.24G>T	c.(22-24)CAG>CAT	p.Q8H		NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	8										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				GGGCTTCTATCTGGTGGTCAT	0.488													19	72					1.15919e-05	1.20817e-05	1	0	A	1657244	A	A	1657244	3	1	113	1	0	0	0	0	1	0	0	0	7595	912	32	2	4480	2	IFT140	16	1657244	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08		1657244	88697509	95	20489											
NUBP2	10101	broad.mit.edu	37	chr16	1836869	1836869	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcacccgtcttcctggacCgggagcagagcatctcgctc	6	7	13	15	3	2	1	0	0	2	1	5	3	3	3	3	3	2	4	3	3	0	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:1836869C>T	uc002cmw.3	+	3	336	c.247C>T	c.(247-249)CGG>TGG	p.R83W	NUBP2_uc002cmx.3_Intron|NUBP2_uc010brx.2_Missense_Mutation_p.R23W	NM_012225	NP_036357	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2 (MinD homolog, E.	83						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding				0						CTTCCTGGACCGGGAGCAGAG	0.677													8	29					0	0	0	0	T	1836869	T	T	1836869	3	4	113	1	0	0	0	0	1	0	0	0	10770	643	23	1	257	1	NUBP2	16	1836869	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	179625	1836869	88517884	96	20490											
GPT2	84706	broad.mit.edu	37	chr16	46934667	46934667	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatgctaagaaacgtgcccGgcggatcctgcaggcttgtg	9	8	14	10	3	0	2	0	0	0	2	1	3	1	3	2	3	4	3	2	3	2	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:46934667G>T	uc002eel.2	+	4	501	c.407G>T	c.(406-408)CGG>CTG	p.R136L	GPT2_uc002eem.2_Missense_Mutation_p.R36L	NM_133443	NP_597700	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase 2 isoform 1	136					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AAACGTGCCCGGCGGATCCTG	0.617													11	25					2.80697e-09	3.01038e-09	1	0	T	46934667	T	T	46934667	3	4	113	1	0	0	0	0	1	0	0	0	6777	1116	39	3	417	3	GPT2	16	46934667	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	45097798	46934667	43420086	97	20491											
SALL1	6299	broad.mit.edu	37	chr16	51175913	51175913	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaggctggattttcatttaCgattaaaactaattgatttt	12	17	8	4	1	1	1	1	1	0	0	1	4	1	3	0	3	2	1	0	3	4	9			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:51175913C>T	uc010vgs.1	-	2	251	c.220G>A	c.(220-222)GTA>ATA	p.V74I	SALL1_uc010vgr.1_5'UTR|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	74					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TTTTCATTTACGATTAAAACT	0.448													27	57					0	0	0	0	T	51175913	T	T	51175913	3	4	113	1	0	0	0	0	1	0	0	0	13875	536	19	1	3762	1	SALL1	16	51175913	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	4241246	51175913	39178840	98	20492											
ZNF319	57567	broad.mit.edu	37	chr16	58031659	58031659	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtggctggctccgctgcctCagctggcttgtaggtctttt	2	14	14	11	1	2	0	1	0	1	0	3	0	3	0	2	5	2	6	2	5	1	4			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:58031659C>T	uc002emx.1	-	2	1134	c.511G>A	c.(511-513)GAG>AAG	p.E171K		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCGCTGCCTCAGCTGGCTTG	0.622													46	88					0	0	0	0	T	58031659	T	T	58031659	3	4	113	1	0	0	0	0	1	0	0	0	17904	835	29	2	1241	2	ZNF319	16	58031659	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	6855746	58031659	32323094	99	20493											
CDH11	1009	broad.mit.edu	37	chr16	65006889	65006889	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagttttaataaaaccatcCtctggattaatagtgaaaaa	17	13	6	5	0	1	1	0	1	1	0	2	2	2	2	2	1	1	2	2	1	8	6			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr16:65006889C>T	uc002eoi.2	-	9	1742	c.1308G>A	c.(1306-1308)GAG>GAA	p.E436E	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Silent_p.E436E|CDH11_uc010vin.1_Silent_p.E310E	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	436	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TAAAACCATCCTCTGGATTAA	0.413			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			10	44					0	0	0	0	T	65006889	T	T	65006889	2	4	113	1	0	0	0	0	0	0	0	1	3112	680	24	4		4	CDH11	16	65006889	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	6975230	65006889	25347864	100	20494											
OR1D2	4991	broad.mit.edu	37	chr17	2995717	2995717	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgtgtgattaatctgaaTgttggaacatgccatcctca	11	13	8	9	0	2	2	1	2	1	0	3	3	3	3	2	1	2	1	2	1	3	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr17:2995717T>C	uc010vrb.1	-	1	574	c.574A>G	c.(574-576)ATT>GTT	p.I192V		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	192	Extracellular (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						TTAATCTGAATGTTGGAACAT	0.448													14	39					0	0	0	0	C	2995717	C	C	2995717	3	2	113	1	0	0	0	0	1	0	0	0	11007	1464	51	5	367	5	OR1D2	17	2995717	Missense_Mutation	SNP	T	TCGA-CQ-7068-01A-11D-2078-08		2995717	78199493	101	20495											
SPNS3	201305	broad.mit.edu	37	chr17	4351571	4351571	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcttcaggagcagctggtGtgaggacgtcagatacctgg	9	8	16	8	1	2	2	2	1	0	1	2	4	2	4	1	5	3	3	1	5	1	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr17:4351571G>A	uc002fxt.2	+	6	787	c.743G>A	c.(742-744)TGT>TAT	p.C248Y	SPNS3_uc002fxu.2_Missense_Mutation_p.C121Y	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	248					lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						AGCAGCTGGTGTGAGGACGTC	0.612													13	13					0	0	0	0	A	4351571	A	A	4351571	3	1	113	1	0	0	0	0	1	0	0	0	15142	1377	48	4	765	4	SPNS3	17	4351571	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	1355854	4351571	76843639	102	20496											
KRT14	3861	broad.mit.edu	37	chr17	39739633	39739633	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctcctccacgctgccaatCatctcctggatctgggccag	6	10	9	16	1	3	0	1	0	2	0	6	1	5	1	5	2	2	2	5	2	1	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr17:39739633C>T	uc002hxf.1	-	6	1189	c.1128G>A	c.(1126-1128)ATG>ATA	p.M376I	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Intron	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	376	Rod.|Coil 2.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				CGCTGCCAATCATCTCCTGGA	0.597													12	27					0	0	0	0	T	39739633	T	T	39739633	3	4	113	1	0	0	0	0	1	0	0	0	8490	826	29	2	302	2	KRT14	17	39739633	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	35388062	39739633	41455577	103	20497											
BAIAP2	10458	broad.mit.edu	37	chr17	79073793	79073793	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtccgacggctacaagacCgcactgacagaggagcgcag	11	4	14	12	4	0	3	0	1	0	2	1	5	1	4	2	2	2	3	2	2	2	1	rs146015006	byFrequency	TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr17:79073793C>T	uc002jzg.2	+	7	663	c.555C>T	c.(553-555)ACC>ACT	p.T185T	BAIAP2_uc002jyz.3_Silent_p.T185T|BAIAP2_uc002jza.2_Silent_p.T185T|BAIAP2_uc002jzc.2_Silent_p.T185T|BAIAP2_uc002jzb.2_5'UTR|BAIAP2_uc002jzd.2_Silent_p.T185T|BAIAP2_uc002jzf.2_Silent_p.T185T|BAIAP2_uc002jze.2_Silent_p.T218T|BAIAP2_uc010wuh.1_Silent_p.T107T|BAIAP2_uc002jzh.2_Silent_p.T186T|BAIAP2_uc010wui.1_Silent_p.T48T	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	185	IMD.				axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GCTACAAGACCGCACTGACAG	0.617													3	39					0	0	0	0	T	79073793	T	T	79073793	2	4	113	1	0	0	0	0	0	0	0	1	1303	639	23	1		1	BAIAP2	17	79073793	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	39334160	79073793	2121417	104	20498											
ZNF532	55205	broad.mit.edu	37	chr18	56620896	56620896	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaaagagaaattggaaaaGaaatctccatctcctgtgaa	17	8	10	6	0	2	3	0	1	2	2	4	6	2	5	2	2	0	0	2	2	6	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr18:56620896G>A	uc002lho.2	+	8	3562	c.3015G>A	c.(3013-3015)AAG>AAA	p.K1005K	ZNF532_uc002lhp.2_Silent_p.K1003K|ZNF532_uc010xeg.1_Silent_p.K1003K|ZNF532_uc002lhr.2_Silent_p.K1003K|ZNF532_uc002lhs.2_Silent_p.K1003K|ZNF532_uc010xeh.1_Silent_p.K97K	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1005					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AATTGGAAAAGAAATCTCCAT	0.428													24	49					0	0	0	0	A	56620896	A	A	56620896	2	1	113	1	0	0	0	0	0	0	0	1	18039	933	33	2		2	ZNF532	18	56620896	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08		56620896	21456352	105	20499											
ODF3L2	284451	broad.mit.edu	37	chr19	463990	463990	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctgctctgggcagtgggCgccagggccgggggtctcct	3	7	18	13	2	2	0	0	0	2	0	3	1	2	0	4	5	1	2	4	5	0	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:463990C>T	uc002lor.2	-	4	960	c.724G>A	c.(724-726)GCC>ACC	p.A242T	SHC2_uc002loq.3_5'Flank|ODF3L2_uc010drp.2_Missense_Mutation_p.A206T	NM_182577	NP_872383	Q3SX64	OD3L2_HUMAN	outer dense fiber of sperm tails 3-like 2	242	DUF1309 3.|Pro-rich.										0						GGGCAGTGGGCGCCAGGGCCG	0.607													4	13					0	0	0	0	T	463990	T	T	463990	3	4	113	1	0	0	0	0	1	0	0	0	10886	768	27	1	149	1	ODF3L2	19	463990	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08		463990	58664993	106	20500											
OR1M1	125963	broad.mit.edu	37	chr19	9204511	9204511	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacacctctgtgaataggatCttcatcctcattgtggcagg	9	12	10	10	0	4	1	2	1	2	0	5	3	5	2	2	3	0	1	2	3	2	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:9204511C>T	uc010xkj.1	+	1	591	c.591C>T	c.(589-591)ATC>ATT	p.I197I		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	197	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						TGAATAGGATCTTCATCCTCA	0.567													19	57					0	0	0	0	T	9204511	T	T	9204511	2	4	113	1	0	0	0	0	0	0	0	1	11022	903	32	2		2	OR1M1	19	9204511	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	8740521	9204511	49924472	107	20501											
ILVBL	10994	broad.mit.edu	37	chr19	15230101	15230101	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcagggaacacccaaggtCtccacggcagccctgggagt	11	4	13	13	1	1	0	0	0	1	0	2	2	1	2	3	4	3	2	3	4	3	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:15230101C>G	uc002nam.2	-	9	1048	c.927G>C	c.(925-927)GAG>GAC	p.E309D	ILVBL_uc010xof.1_5'Flank|ILVBL_uc010dzw.2_Missense_Mutation_p.E202D	NM_006844	NP_006835	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	309						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			ovary(2)	2						CACCCAAGGTCTCCACGGCAG	0.672													10	36					0	0	0	0	G	15230101	G	G	15230101	3	3	113	1	0	0	0	0	1	0	0	0	7754	912	32	2	1003	2	ILVBL	19	15230101	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	6025590	15230101	43898882	108	20502											
ZNF43	7594	broad.mit.edu	37	chr19	21992490	21992491	+	Frame_Shift_Ins	INS	-	T	T																															tcatccacacttttatggtcINStttttttaaatgtacatttt																										TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:21992490_21992491insT	uc002nqj.2	-	4	478_479	c.348_349insA	c.(346-351)AAAGACfs	p.K116fs	ZNF43_uc010ecv.2_Frame_Shift_Ins_p.K110fs|ZNF43_uc002nql.2_Frame_Shift_Ins_p.K110fs|ZNF43_uc002nqm.2_Frame_Shift_Ins_p.K110fs|ZNF43_uc002nqk.2_Frame_Shift_Ins_p.K46fs	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	116_117					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		CTTTTATGGTCTTTTTTTAAAT	0.351													---	---	---								T	21992491	T	T	21992490	7	5	113	1	0	1	1	0	0	0	0	0	17970	913	32	0	2084	0	ZNF43	19	21992490	Frame_Shift_Ins	INS	-	TCGA-CQ-7068-01A-11D-2078-08	6762389	21992490	37136493	109	20503											
ZNF382	84911	broad.mit.edu	37	chr19	37118156	37118156	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaaaagacaaccctcactCtccaccagagaattcacacg	15	5	5	16	1	3	2	2	0	1	2	4	3	3	2	4	0	1	0	4	0	4	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:37118156C>T	uc002oek.2	+	5	1470	c.1357C>T	c.(1357-1359)CTC>TTC	p.L453F	ZNF382_uc010efa.2_Missense_Mutation_p.L404F|ZNF382_uc010efb.2_Missense_Mutation_p.L452F|ZNF382_uc002oel.2_Missense_Mutation_p.L452F	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	453	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).|C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AACCCTCACTCTCCACCAGAG	0.453													9	35					0	0	0	0	T	37118156	T	T	37118156	3	4	113	1	0	0	0	0	1	0	0	0	17940	913	32	2	1367	2	ZNF382	19	37118156	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	15125666	37118156	22010827	110	20504											
AXL	558	broad.mit.edu	37	chr19	41726662	41726662	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gagccccccgaggtacattgGcttcgggatggacagatcct	8	8	13	12	2	0	1	0	0	0	1	2	5	1	3	4	4	2	2	4	4	1	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:41726662G>A	uc010ehj.2	+	2	397	c.207G>A	c.(205-207)TGG>TGA	p.W69*	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Nonsense_Mutation_p.W69*|AXL_uc010ehk.2_Nonsense_Mutation_p.W69*	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	69	Extracellular (Potential).|Interaction with GAS6.|Ig-like C2-type 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						AGGTACATTGGCTTCGGGATG	0.627													12	28					0	0	0	0	A	41726662	A	A	41726662	4	1	113	1	0	0	0	0	0	1	0	0	1240	1212	42	4	213	4	AXL	19	41726662	Nonsense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	4608506	41726662	17402321	111	20505											
DMRTC2	63946	broad.mit.edu	37	chr19	42351824	42351824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcgccgcagggtcatggCtgcccaggtggccttgcgta	5	7	17	12	3	1	0	1	0	0	0	1	1	1	1	3	5	3	3	3	5	1	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:42351824C>T	uc002ors.2	+	3	328	c.245C>T	c.(244-246)GCT>GTT	p.A82V	DMRTC2_uc002orr.1_5'UTR|DMRTC2_uc010xwe.1_Missense_Mutation_p.A82V	NM_001040283	NP_001035373	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	82	DM.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						AGGGTCATGGCTGCCCAGGTG	0.592													5	4					0	0	0	0	T	42351824	T	T	42351824	3	4	113	1	0	0	0	0	1	0	0	0	4613	797	28	4	251	4	DMRTC2	19	42351824	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	625162	42351824	16777159	112	20506											
ZC3H4	23211	broad.mit.edu	37	chr19	47575163	47575163	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggagtctccagggccgtagGgcatcattggagggccgcca	7	6	17	11	2	2	0	1	0	1	0	3	2	2	2	4	5	0	2	4	5	1	2	rs149041592		TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:47575163G>T	uc002pga.3	-	13	2056	c.2018C>A	c.(2017-2019)CCC>CAC	p.P673H	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	673	Pro-rich.						nucleic acid binding|zinc ion binding	p.P673L(1)		skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		AGGGCCGTAGGGCATCATTGG	0.493													6	16					0.00116845	0.00118445	1	0	T	47575163	T	T	47575163	3	4	113	1	0	0	0	0	1	0	0	0	17637	1232	43	4	1905	4	ZC3H4	19	47575163	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	5223339	47575163	11553820	113	20507											
SPHK2	56848	broad.mit.edu	37	chr19	49132292	49132292	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaccccagacccagccccGcccatggcccactcacccct	8	4	5	24	1	1	1	1	0	0	1	1	1	1	1	9	1	2	0	9	1	1	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:49132292G>A	uc002pjr.2	+	7	1593	c.1227G>A	c.(1225-1227)CCG>CCA	p.P409P	SPHK2_uc010xzt.1_Silent_p.P350P|SPHK2_uc002pjs.2_Silent_p.P409P|SPHK2_uc002pjt.2_Silent_p.P203P|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Silent_p.P373P|SPHK2_uc002pjw.2_Silent_p.P471P	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	409					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		Acccagccccgcccatggccc	0.343													8	22					0	0	0	0	A	49132292	A	A	49132292	2	1	113	1	0	0	0	0	0	0	0	1	15113	1074	38	1		1	SPHK2	19	49132292	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	1557129	49132292	9996691	114	20508											
TULP2	7288	broad.mit.edu	37	chr19	49399725	49399725	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctcctcccgcagacaagagCgccaaagccacggggaagcg	11	2	13	15	4	0	2	0	0	0	2	2	3	2	3	4	2	3	2	4	2	3	0			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr19:49399725C>T	uc002pkz.2	-	4	324	c.173G>A	c.(172-174)CGC>CAC	p.R58H		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	58					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		CAGACAAGAGCGCCAAAGCCA	0.637													17	29					0	0	0	0	T	49399725	T	T	49399725	3	4	113	1	0	0	0	0	1	0	0	0	16842	768	27	1	1429	1	TULP2	19	49399725	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	267433	49399725	9729258	115	20509											
BCAS1	8537	broad.mit.edu	37	chr20	52644969	52644969	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcggactgccctgataagcCaggaacctcatccaccttgt	10	9	8	14	1	1	1	1	1	0	0	3	3	2	3	5	2	3	0	5	2	2	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr20:52644969C>T	uc002xws.2	-	4	1023	c.685G>A	c.(685-687)GGC>AGC	p.G229S	BCAS1_uc010zzb.1_Missense_Mutation_p.G132S|BCAS1_uc010gim.2_Missense_Mutation_p.G132S|BCAS1_uc002xwt.2_Missense_Mutation_p.G229S|BCAS1_uc010gil.1_Missense_Mutation_p.G229S|BCAS1_uc010zzc.1_Missense_Mutation_p.G132S	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	229						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CCTGATAAGCCAGGAACCTCA	0.532													52	144					0	0	0	0	T	52644969	T	T	52644969	3	4	113	1	0	0	0	0	1	0	0	0	1352	594	21	4	1105	4	BCAS1	20	52644969	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08		52644969	10380551	116	20510											
RGL4	266747	broad.mit.edu	37	chr22	24035110	24035110	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtaaagaaccaacccagtGaggagctgcctgacatgacg	13	6	11	11	1	0	4	0	3	0	1	0	5	0	5	3	1	4	2	3	1	4	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr22:24035110G>A	uc002zxn.2	+	3	1798	c.628G>A	c.(628-630)GAG>AAG	p.E210K	LOC91316_uc002zxh.3_RNA|LOC91316_uc002zxi.3_RNA|LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Missense_Mutation_p.E210K|RGL4_uc002zxp.1_Missense_Mutation_p.E74K|RGL4_uc002zxq.2_Missense_Mutation_p.E74K	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	210	Pro-rich.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						CCAACCCAGTGAGGAGCTGCC	0.622													8	31					0	0	0	0	A	24035110	A	A	24035110	3	1	113	1	0	0	0	0	1	0	0	0	13344	1291	45	2	638	2	RGL4	22	24035110	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08		24035110	27269456	117	20511											
C22orf13	83606	broad.mit.edu	37	chr22	24943916	24943916	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgacacccagggtctgggtaCagaagcggtgcctcacgcca	9	5	13	14	3	2	1	1	0	1	1	2	2	2	1	3	3	3	1	3	3	2	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chr22:24943916C>A	uc003aah.2	-	3	570	c.254G>T	c.(253-255)TGT>TTT	p.C85F	C22orf13_uc003aal.2_Missense_Mutation_p.C141F|C22orf13_uc003aai.3_Missense_Mutation_p.C85F|C22orf13_uc003aaj.3_Missense_Mutation_p.C85F|C22orf13_uc003aak.3_Missense_Mutation_p.C141F	NM_031444	NP_113632	Q96NT3	CV013_HUMAN	chromosome 22 open reading frame 13	85											0						GGTCTGGGTACAGAAGCGGTG	0.602													19	35					5.35267e-07	5.65853e-07	1	0	A	24943916	A	A	24943916	3	1	113	1	0	0	0	0	1	0	0	0	2145	478	17	4	484	4	C22orf13	22	24943916	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	908806	24943916	26360650	118	20512											
FAM47C	442444	broad.mit.edu	37	chrX	37026576	37026576	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgccttccaagtacttcgcGaagcgcaagcacaggcgcct	9	6	10	16	5	0	0	0	0	0	0	2	1	1	0	4	1	3	3	4	1	4	3			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:37026576G>A	uc004ddl.1	+	1	107	c.93G>A	c.(91-93)GCG>GCA	p.A31A		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	31										ovary(3)	3						AGTACTTCGCGAAGCGCAAGC	0.642													12	10					0	0	0	0	A	37026576	A	A	37026576	2	1	113	1	0	0	0	0	0	0	0	1	5603	1045	37	1		1	FAM47C	23	37026576	Silent	SNP	G	TCGA-CQ-7068-01A-11D-2078-08		37026576	118243984	119	20513											
SPANXN5	494197	broad.mit.edu	37	chrX	52825613	52825613	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atactgttgaatattctgatGttttcatctttttcaaactc	10	20	4	7	0	4	2	2	2	2	0	5	2	4	2	0	0	2	2	0	0	4	8			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:52825613G>C	uc004drc.1	-	2	134	c.134C>G	c.(133-135)ACA>AGA	p.T45R		NM_001009616	NP_001009616	Q5MJ07	SPXN5_HUMAN	SPANX family, member N5	45											0	Ovarian(276;0.236)					ATATTCTGATGTTTTCATCTT	0.393													3	47					0	0	0	0	C	52825613	C	C	52825613	3	2	113	1	0	0	0	0	1	0	0	0	15060	1377	48	4	88	4	SPANXN5	23	52825613	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	15799037	52825613	102444947	120	20514											
HUWE1	10075	broad.mit.edu	37	chrX	53563194	53563194	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtagaagtggtaatcttCactctccatatctgtatatc	10	16	7	8	0	4	1	1	0	3	1	6	1	4	1	1	2	0	3	1	2	6	7			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:53563194C>T	uc004dsp.2	-	80	12847	c.12445G>A	c.(12445-12447)GAA>AAA	p.E4149K	HUWE1_uc004dsn.2_Missense_Mutation_p.E2957K	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4149	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TGGTAATCTTCACTCTCCATA	0.448													11	22					0	0	0	0	T	53563194	T	T	53563194	3	4	113	1	0	0	0	0	1	0	0	0	7500	835	29	2	699	2	HUWE1	23	53563194	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	737581	53563194	101707366	121	20515											
ZXDA	7789	broad.mit.edu	37	chrX	57935195	57935196	+	Frame_Shift_Del	DEL	AG	-	-																															catgctgtgcttggatgtgaAgagtttattacaagaggaga																										TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:57935195_57935196delAG	uc004dve.2	-	1	1872_1873	c.1659_1660delCT	c.(1657-1662)CTCTTCfs	p.L553fs		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	553_554	C2H2-type 10.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TTGGATGTGAAGAGTTTATTAC	0.485													---	---	---								-	57935196	-	-	57935195	7	5	113	1	0	1	0	1	0	0	0	0	18317	72	3	0	743	0	ZXDA	23	57935195	Frame_Shift_Del	DEL	AG	TCGA-CQ-7068-01A-11D-2078-08	4372001	57935195	97335365	122	20516											
CHM	1121	broad.mit.edu	37	chrX	85302517	85302517	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttacgatcacatcaaactccGaagggagagtatccgccatc	13	8	8	12	3	2	1	2	0	0	1	5	4	4	1	3	1	2	1	3	1	4	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:85302517G>A	uc004eet.2	-	1	50	c.20C>T	c.(19-21)TCG>TTG	p.S7L	CHM_uc011mqz.1_5'UTR|CHM_uc004eeu.3_5'Flank|CHM_uc004eev.3_Missense_Mutation_p.S7L	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	7					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				ATCAAACTCCGAAGGGAGAGT	0.468													7	4					0	0	0	0	A	85302517	A	A	85302517	3	1	113	1	0	0	0	0	1	0	0	0	3365	1059	37	1	2024	1	CHM	23	85302517	Missense_Mutation	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	27367322	85302517	69968043	123	20517											
IGSF1	3547	broad.mit.edu	37	chrX	130416550	130416550	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagaatgatgtgttgtcatCgatgctggtggcatccaaaa	12	11	12	6	1	1	2	1	1	0	1	3	4	2	2	1	2	1	3	1	2	4	1			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:130416550C>T	uc004ewd.2	-	7	1352	c.1114G>A	c.(1114-1116)GAT>AAT	p.D372N	IGSF1_uc004ewe.3_Missense_Mutation_p.D361N|IGSF1_uc004ewf.2_Missense_Mutation_p.D352N	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	372	Ig-like C2-type 4.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GTGTTGTCATCGATGCTGGTG	0.468													38	28					0	0	0	0	T	130416550	T	T	130416550	3	4	113	1	0	0	0	0	1	0	0	0	7635	884	31	1	2967	1	IGSF1	23	130416550	Missense_Mutation	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	45114033	130416550	24854010	124	20518											
MAGEA12	4111	broad.mit.edu	37	chrX	151896334	151896334	+	RNA	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgggtccctgttcccttccGggttgtcttggcaacctgga	4	12	12	13	2	1	0	0	0	1	0	4	1	4	1	4	4	1	3	4	4	1	4	rs2515828	by1000genomes	TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:151896334G>A	uc004fgb.2	-	4		c.433C>T						P43365	MAGAC_HUMAN	Homo sapiens melanoma antigen family A, 12, mRNA (cDNA clone MGC:4914 IMAGE:3450217), complete cds.											skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GTTCCCTTCCGGGTTGTCTTG	0.527													4	50					0	0	0	0	A	151896334	A	A	151896334	1	1	113	0	1	0	0	0	0	0	0	0	9217	1131	39	1		1	MAGEA12	23	151896334	RNA	SNP	G	TCGA-CQ-7068-01A-11D-2078-08	21479784	151896334	3374226	125	20519											
ATP2B3	492	broad.mit.edu	37	chrX	152813447	152813447	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaaagctagccgtgcagatCgggaaagcaggtagggacag	14	4	15	8	2	0	1	0	0	0	1	1	3	0	3	1	3	4	4	1	3	4	2			TCGA-CQ-7068-01A-11D-2078-08	TCGA-CQ-7068-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	97a96e61-f2dc-4af4-807a-3925c1ffbf43	526c06c6-9eb5-4273-a2cb-0162444e9d46	g.chrX:152813447C>T	uc004fht.1	+	7	1239	c.1113C>T	c.(1111-1113)ATC>ATT	p.I371I	ATP2B3_uc004fhs.1_Silent_p.I371I	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	371	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGTGCAGATCGGGAAAGCAG	0.597													12	22					0	0	0	0	T	152813447	T	T	152813447	2	4	113	1	0	0	0	0	0	0	0	1	1143	874	31	1		1	ATP2B3	23	152813447	Silent	SNP	C	TCGA-CQ-7068-01A-11D-2078-08	917113	152813447	2457113	126	20520											
IL22RA1	58985	broad.mit.edu	37	chr1	24465129	24465129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccggcccgctgtcccacGtcaggatgttttcaaagttg	6	11	10	14	3	2	0	2	0	0	0	4	1	4	1	4	2	0	3	4	2	1	3			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:24465129G>A	uc001biq.1	-	2	158	c.119C>T	c.(118-120)ACG>ATG	p.T40M	IL22RA1_uc010oeg.1_5'Flank|IL22RA1_uc009vrb.1_Translation_Start_Site|IL22RA1_uc010oeh.1_Missense_Mutation_p.T40M	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	40	Extracellular (Potential).|Fibronectin type-III 1.					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GCTGTCCCACGTCAGGATGTT	0.582													14	84					0	0	0	0	A	24465129	A	A	24465129	3	1	114	1	0	0	0	0	1	0	0	0	7712	1145	40	1	1629	1	IL22RA1	1	24465129	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08		24465129	224785492	1	20521											
AIM1L	55057	broad.mit.edu	37	chr1	26671979	26671979	+	5'Flank	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acgggcccgtccttttttttAgggggcagaacaaggggagt	8	10	15	8	2	0	1	0	0	0	1	1	2	1	2	2	5	1	1	2	5	3	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:26671979A>T	uc001bmd.3	-						uc009vsi.1_Silent_p.P390P	NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like								sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		CCTTTTTTTTAGGGGGCAGAA	0.642													4	71					0	0	0	0	T	26671979	T	T	26671979	1	4	114	0	1	0	0	0	0	0	0	0	431	435	15	5		5	AIM1L	1	26671979	5'Flank	SNP	A	TCGA-CR-5243-01A-01D-1512-08	2206850	26671979	222578642	2	20522											
EIF2C3	192669	broad.mit.edu	37	chr1	36474311	36474311	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttgaaggttgaagtgactCattgtggaacaatgagacgg	12	11	14	4	1	1	4	1	4	0	1	1	6	1	5	0	3	1	2	0	3	4	3			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:36474311C>G	uc001bzp.2	+	7	1070	c.814C>G	c.(814-816)CAT>GAT	p.H272D	EIF2C3_uc001bzq.2_Missense_Mutation_p.H38D	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	272	PAZ.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGAAGTGACTCATTGTGGAAC	0.393													39	100					0	0	0	0	G	36474311	G	G	36474311	3	3	114	1	0	0	0	0	1	0	0	0	5029	826	29	2	840	2	EIF2C3	1	36474311	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	9802332	36474311	212776310	3	20523											
LRRC41	10489	broad.mit.edu	37	chr1	46745880	46745880	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaccttgcagagtcagattCtgtagcaaaaagagcacctc	13	10	8	10	0	2	3	1	0	1	3	3	3	2	3	2	0	4	4	2	0	4	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:46745880C>T	uc001cpn.2	-	7	2048	c.2004G>A	c.(2002-2004)CAG>CAA	p.Q668Q	LRRC41_uc010omb.1_Silent_p.Q668Q	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	668										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					GAGTCAGATTCTGTAGCAAAA	0.303													25	67					0	0	0	0	T	46745880	T	T	46745880	2	4	114	1	0	0	0	0	0	0	0	1	9049	912	32	2		2	LRRC41	1	46745880	Silent	SNP	C	TCGA-CR-5243-01A-01D-1512-08	10271569	46745880	202504741	4	20524											
HFM1	164045	broad.mit.edu	37	chr1	91727872	91727872	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttataatttgaagaatttggGtttttttcagagaaagtaaa	15	17	8	1	0	1	3	1	1	0	2	1	4	1	3	0	1	0	2	0	1	7	8			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:91727872G>T	uc001doa.3	-	38	4264	c.4164C>A	c.(4162-4164)AAC>AAA	p.N1388K	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.N1067K|HFM1_uc001dob.3_Missense_Mutation_p.N576K	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1388							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AAGAATTTGGGTTTTTTTCAG	0.284													50	83					4.00472e-15	4.48528e-15	1	0	T	91727872	T	T	91727872	3	4	114	1	0	0	0	0	1	0	0	0	7122	1252	44	4	151	4	HFM1	1	91727872	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	44981992	91727872	157522749	5	20525											
CSDE1	7812	broad.mit.edu	37	chr1	115261328	115261328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcaagcgattgaccaacCgatcaggtcgaggagctgca	11	8	11	11	3	3	1	2	1	1	0	4	5	3	2	2	2	4	2	2	2	2	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:115261328C>T	uc001efk.2	-	19	2721	c.2255G>A	c.(2254-2256)CGG>CAG	p.R752Q	NRAS_uc009wgu.2_5'Flank|CSDE1_uc001efi.2_Missense_Mutation_p.R798Q|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.R721Q|CSDE1_uc001efm.2_Missense_Mutation_p.R767Q|CSDE1_uc009wgv.2_Missense_Mutation_p.R752Q|CSDE1_uc001efn.2_Missense_Mutation_p.R721Q	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	752					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATTGACCAACCGATCAGGTCG	0.498													3	71					0	0	0	0	T	115261328	T	T	115261328	3	4	114	1	0	0	0	0	1	0	0	0	3946	652	23	1	149	1	CSDE1	1	115261328	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	23533456	115261328	133989293	6	20526											
RORC	6097	broad.mit.edu	37	chr1	151804261	151804261	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcagctcccttggtgccGtcctggctgccctggctgcc	1	9	15	16	1	0	0	0	0	0	0	2	0	2	0	5	5	4	4	5	5	0	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:151804261G>A	uc001ezh.2	-	1	88	c.-20C>T	c.(-22--18)GACGG>GATGG		RORC_uc010pdo.1_Translation_Start_Site|RORC_uc010pdp.1_Translation_Start_Site	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CCTTGGTGCCGTCCTGGCTGC	0.711													45	78					0	0	0	0	A	151804261	A	A	151804261	1	1	114	1	0	0	0	0	0	0	0	0	13595	1160	40	1		1	RORC	1	151804261	Translation_Start_Site	SNP	G	TCGA-CR-5243-01A-01D-1512-08	36542933	151804261	97446360	7	20527											
TMEM79	84283	broad.mit.edu	37	chr1	156255560	156255560	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgaggcagtggtgaggccGcctggctgttcctgtggggg	3	9	20	9	1	0	2	0	2	0	0	1	2	1	2	3	6	0	4	3	6	0	1	rs140033065	byFrequency	TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:156255560G>A	uc010phi.1	+	2	739	c.543G>A	c.(541-543)CCG>CCA	p.P181P	SMG5_uc001foc.3_5'Flank|TMEM79_uc001fod.2_Silent_p.P22P|TMEM79_uc009wrw.2_Silent_p.P181P	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	181						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					TGGTGAGGCCGCCTGGCTGTT	0.682													35	52					0	0	0	0	A	156255560	A	A	156255560	2	1	114	1	0	0	0	0	0	0	0	1	16269	1074	38	1		1	TMEM79	1	156255560	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08	4451299	156255560	92995061	8	20528											
AKT3	10000	broad.mit.edu	37	chr1	243727052	243727052	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatattctggagtgccacaGaatgtcttcatggtggctgc	9	12	12	8	0	3	2	1	0	2	2	3	3	3	3	1	3	2	1	1	3	2	3			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr1:243727052G>A	uc001iab.1	-	9	999	c.918C>T	c.(916-918)TTC>TTT	p.F306F	AKT3_uc001hzz.1_Silent_p.F306F	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	306	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GAGTGCCACAGAATGTCTTCA	0.398													38	131					0	0	0	0	A	243727052	A	A	243727052	2	1	114	1	0	0	0	0	0	0	0	1	481	933	33	2		2	AKT3	1	243727052	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08	87471492	243727052	5523569	9	20529											
YWHAQ	10971	broad.mit.edu	37	chr2	9770492	9770492	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacagctcggcgccctgctcGgtcactgccttcatgcaggt	5	9	12	15	3	2	0	2	0	0	0	4	1	2	0	2	3	4	3	2	3	0	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:9770492G>C	uc002qzw.2	-	1	254	c.90C>G	c.(88-90)ACC>ACG	p.T30T	YWHAQ_uc002qzx.2_Silent_p.T30T	NM_006826	NP_006817	P27348	1433T_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	30					negative regulation of transcription, DNA-dependent	centrosome|nucleus	protein N-terminus binding			breast(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.241)		CGCCCTGCTCGGTCACTGCCT	0.607													25	28					0	0	0	0	C	9770492	C	C	9770492	2	2	114	1	0	0	0	0	0	0	0	1	17573	1103	39	3		3	YWHAQ	2	9770492	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08		9770492	233428881	10	20530											
REG1B	5968	broad.mit.edu	37	chr2	79313560	79313560	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tactctccttaatcagtgagGccacgaaggcaccctccgcc	9	8	8	16	2	2	1	1	1	1	0	4	2	3	1	5	2	1	1	5	2	3	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:79313560G>T	uc002sny.2	-	4	366	c.254C>A	c.(253-255)GCC>GAC	p.A85D	REG1B_uc010ffv.1_Missense_Mutation_p.A85D|REG1B_uc010ffw.2_3'UTR	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	85	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						AATCAGTGAGGCCACGAAGGC	0.502													56	66					2.5401e-28	2.96345e-28	1	0	T	79313560	T	T	79313560	3	4	114	1	0	0	0	0	1	0	0	0	13276	1203	42	4	258	4	REG1B	2	79313560	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	69543068	79313560	163885813	11	20531											
ACTR1B	10120	broad.mit.edu	37	chr2	98274472	98274472	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtccggcgcaggtccatgtCggacttgtgtatggcgaagg	6	9	16	10	5	0	0	0	0	0	0	3	2	2	1	2	5	0	2	2	5	2	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:98274472C>T	uc002syb.2	-	8	1067	c.859G>A	c.(859-861)GAC>AAC	p.D287N		NM_005735	NP_005726	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B,	287						centrosome|dynactin complex	ATP binding|protein binding			skin(1)	1						AGGTCCATGTCGGACTTGTGT	0.607													5	128					0	0	0	0	T	98274472	T	T	98274472	3	4	114	1	0	0	0	0	1	0	0	0	210	884	31	1	287	1	ACTR1B	2	98274472	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	18960912	98274472	144924901	12	20532											
HS6ST1	9394	broad.mit.edu	37	chr2	129026403	129026403	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccgccactcgctcaggtagCgggacacggggtctcgtagc	6	6	15	14	5	2	0	1	0	1	0	4	1	2	1	2	4	2	3	2	4	2	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:129026403C>G	uc002tpt.3	-	2	603	c.569G>C	c.(568-570)CGC>CCC	p.R190P		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	190	Lumenal (Potential).|3'-phosphate binding (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		GCTCAGGTAGCGGGACACGGG	0.642													19	53					0	0	0	0	G	129026403	G	G	129026403	3	3	114	1	0	0	0	0	1	0	0	0	7409	768	27	3	670	3	HS6ST1	2	129026403	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	30751931	129026403	114172970	13	20533											
GMPPA	29926	broad.mit.edu	37	chr2	220368880	220368880	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatctacctcttttctcctGaagccttgaagcctcttcgg	6	14	7	14	1	4	2	0	2	4	0	6	2	4	2	4	1	3	1	4	1	3	5			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:220368880G>A	uc002vlr.2	+	7	633	c.565G>A	c.(565-567)GAA>AAA	p.E189K	GMPPA_uc002vls.2_Missense_Mutation_p.E189K|GMPPA_uc002vlt.2_Missense_Mutation_p.E189K|GMPPA_uc002vlu.2_Missense_Mutation_p.E189K|GMPPA_uc002vlv.2_Missense_Mutation_p.E189K|GMPPA_uc002vlw.2_RNA|GMPPA_uc002vlx.2_Missense_Mutation_p.E189K	NM_013335	NP_037467	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	189					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		CTTTTCTCCTGAAGCCTTGAA	0.527													5	128					0	0	0	0	A	220368880	A	A	220368880	3	1	114	1	0	0	0	0	1	0	0	0	6531	1291	45	2	587	2	GMPPA	2	220368880	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	91342477	220368880	22830493	14	20534											
HTR2B	3357	broad.mit.edu	37	chr2	231973477	231973477	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtttttactgactttgtggcCcggtaattgcaggtgatata	8	16	11	6	1	0	2	0	2	0	0	0	2	0	2	1	3	2	3	1	3	4	8			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr2:231973477C>A	uc002vro.2	-	4	1705	c.1200G>T	c.(1198-1200)CGG>CGT	p.R400R	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Silent_p.R333R	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	400	Cytoplasmic (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	ACTTTGTGGCCCGGTAATTGC	0.428													4	147					0.00909568	0.00952071	1	0	A	231973477	A	A	231973477	2	1	114	1	0	0	0	0	0	0	0	1	7481	610	22	4		4	HTR2B	2	231973477	Silent	SNP	C	TCGA-CR-5243-01A-01D-1512-08	11604597	231973477	11225896	15	20535											
FGD5	152273	broad.mit.edu	37	chr3	14960293	14960293	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgatggagaaagtgccctaCgctctaaagattgagacttc	12	10	11	8	1	1	4	0	2	1	3	2	6	1	4	1	1	2	1	1	1	4	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:14960293C>A	uc003bzc.2	+	13	3632	c.3522C>A	c.(3520-3522)TAC>TAA	p.Y1174*	FGD5_uc011avk.1_Nonsense_Mutation_p.Y1174*|FGD5_uc003bzd.2_Nonsense_Mutation_p.Y252*	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1174	PH 1.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						AAGTGCCCTACGCTCTAAAGA	0.602													19	9					3.5997e-14	3.99175e-14	1	0	A	14960293	A	A	14960293	4	1	114	1	0	0	0	0	0	1	0	0	5868	547	19	3	3572	3	FGD5	3	14960293	Nonsense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08		14960293	183062137	16	20536											
KIAA1524	57650	broad.mit.edu	37	chr3	108285471	108285471	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatgcatttttagtgtatCatctccacagagaggttaag	13	14	8	6	0	2	1	1	0	1	1	3	2	2	1	1	1	1	3	1	1	5	6			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:108285471C>A	uc003dxb.3	-	11	1557	c.1288G>T	c.(1288-1290)GAT>TAT	p.D430Y	KIAA1524_uc010hpv.1_5'UTR	NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	430						cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						TTTAGTGTATCATCTCCACAG	0.303													4	172					0.00909568	0.00952071	1	0	A	108285471	A	A	108285471	3	1	114	1	0	0	0	0	1	0	0	0	8278	826	29	2	1473	2	KIAA1524	3	108285471	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	93325178	108285471	89736959	17	20537											
GK5	256356	broad.mit.edu	37	chr3	141884548	141884548	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatattcttgacatttcttCtgtggcttgaaaaccacttc	9	17	5	10	0	4	2	1	2	3	0	5	2	4	2	1	1	1	1	1	1	3	7			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:141884548C>A	uc003euq.1	-	16	1637	c.1506G>T	c.(1504-1506)CAG>CAT	p.Q502H	GK5_uc003eup.1_Missense_Mutation_p.Q223H|GK5_uc010hus.1_RNA	NM_001039547	NP_001034636	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	502					glycerol metabolic process		ATP binding|glycerol kinase activity				0						GACATTTCTTCTGTGGCTTGA	0.353													87	209					9.1841e-55	1.08276e-54	1	0	A	141884548	A	A	141884548	3	1	114	1	0	0	0	0	1	0	0	0	6459	912	32	2	87	2	GK5	3	141884548	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	33599077	141884548	56137882	18	20538											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			41	85					0	0	0	0	A	178936082	A	A	178936082	3	1	114	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	37051534	178936082	19086348	19	20539											
EIF2B5	8893	broad.mit.edu	37	chr3	183855991	183855991	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagtgatggagtggaggttcGatatgatttactggattgtc	9	15	14	3	1	0	2	0	2	0	0	2	6	0	5	0	4	1	1	0	4	3	6			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:183855991G>A	uc003fmp.2	+	5	1086	c.722G>A	c.(721-723)CGA>CAA	p.R241Q	EIF2B5_uc003fmq.2_5'UTR	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,	241					astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GTGGAGGTTCGATATGATTTA	0.483													46	117					0	0	0	0	A	183855991	A	A	183855991	3	1	114	1	0	0	0	0	1	0	0	0	5026	1058	37	1	740	1	EIF2B5	3	183855991	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	4919909	183855991	14166439	20	20540											
IL1RAP	3556	broad.mit.edu	37	chr3	190366168	190366168	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcattcagaaaagcagaCgcctcctggttgttctaagc	10	11	9	11	1	3	2	2	0	1	2	4	2	4	2	2	1	2	4	2	1	3	5			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:190366168C>T	uc003fsm.1	+	12	1593	c.1387C>T	c.(1387-1389)CGC>TGC	p.R463C	IL1RAP_uc010hzg.1_Missense_Mutation_p.R463C|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Missense_Mutation_p.R463C|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Intron	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	463	Cytoplasmic (Potential).|TIR.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		GAAAAGCAGACGCCTCCTGGT	0.502													120	343					0	0	0	0	T	190366168	T	T	190366168	3	4	114	1	0	0	0	0	1	0	0	0	7699	536	19	1	1445	1	IL1RAP	3	190366168	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	6510177	190366168	7656262	21	20541											
HRASLS	57110	broad.mit.edu	37	chr3	192980878	192980878	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acagaataaacaataaatacGatgaaacgtacccccctctc	18	7	4	12	2	1	2	0	1	1	1	2	3	1	2	3	0	4	1	3	0	9	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr3:192980878G>C	uc003fta.2	+	3	664	c.259G>C	c.(259-261)GAT>CAT	p.D87H		NM_020386	NP_065119	Q9HDD0	HRSL1_HUMAN	HRAS-like suppressor	87											0	all_cancers(143;9.1e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000159)		CAATAAATACGATGAAACGTA	0.433													78	203					0	0	0	0	C	192980878	C	C	192980878	3	2	114	1	0	0	0	0	1	0	0	0	7388	1058	37	3	265	3	HRASLS	3	192980878	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	2614710	192980878	5041552	22	20542											
EVC2	132884	broad.mit.edu	37	chr4	5664846	5664846	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcttactcttctaaggctTgaagcatgctcccagggtcc	8	13	8	12	0	3	1	0	1	3	0	5	1	5	1	2	2	3	3	2	2	3	5			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:5664846T>G	uc003gij.2	-	9	1187	c.1133A>C	c.(1132-1134)CAA>CCA	p.Q378P	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.Q298P	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	378						integral to membrane				large_intestine(3)|ovary(2)	5						TTCTAAGGCTTGAAGCATGCT	0.428													37	133					0	0	0	0	G	5664846	G	G	5664846	3	3	114	1	0	0	0	0	1	0	0	0	5310	1812	63	5	2849	5	EVC2	4	5664846	Missense_Mutation	SNP	T	TCGA-CR-5243-01A-01D-1512-08		5664846	185489430	23	20543											
CD38	952	broad.mit.edu	37	chr4	15818249	15818249	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaagttgggaactcagaccGtaccttgcaacaaggtaatt	13	10	10	8	1	1	2	1	1	0	1	1	3	1	3	2	2	4	4	2	2	6	5			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:15818249G>A	uc011bxc.1	+	2	456	c.349G>A	c.(349-351)GTA>ATA	p.V117I	CD38_uc003goj.1_Missense_Mutation_p.V117I|CD38_uc003gol.1_Missense_Mutation_p.V117I	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	117	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						AACTCAGACCGTACCTTGCAA	0.378													4	152					0	0	0	0	A	15818249	A	A	15818249	3	1	114	1	0	0	0	0	1	0	0	0	3024	1145	40	1	355	1	CD38	4	15818249	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	10153403	15818249	175336027	24	20544											
PTPN13	5783	broad.mit.edu	37	chr4	87653773	87653773	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agggaagaatgaggataaccGaaggaaagtaaacataatgc	20	5	12	4	1	0	2	0	1	0	1	0	6	0	5	1	3	3	1	1	3	8	3			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:87653773G>A	uc003hpz.2	+	12	2192	c.1712G>A	c.(1711-1713)CGA>CAA	p.R571Q	PTPN13_uc003hpy.2_Missense_Mutation_p.R571Q|PTPN13_uc003hqa.2_Missense_Mutation_p.R571Q|PTPN13_uc003hqb.2_Missense_Mutation_p.R571Q	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	571						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		GAGGATAACCGAAGGAAAGTA	0.328													30	68					0	0	0	0	A	87653773	A	A	87653773	3	1	114	1	0	0	0	0	1	0	0	0	12845	1058	37	1	1754	1	PTPN13	4	87653773	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	71835524	87653773	103500503	25	20545											
PKD2	5311	broad.mit.edu	37	chr4	88973183	88973183	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattaacatatacagaacatCaaatgtggaggtgctactac	17	10	7	7	0	1	1	1	0	0	1	1	2	1	2	0	2	6	1	0	2	8	5			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:88973183C>G	uc003hre.2	+	7	1655	c.1589C>G	c.(1588-1590)TCA>TGA	p.S530*	PKD2_uc011cdf.1_Translation_Start_Site|PKD2_uc011cdg.1_Translation_Start_Site|PKD2_uc011cdh.1_Translation_Start_Site	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	530	Extracellular (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		TACAGAACATCAAATGTGGAG	0.333													18	80					0	0	0	0	G	88973183	G	G	88973183	4	3	114	1	0	0	0	0	0	1	0	0	12021	838	29	2	1615	2	PKD2	4	88973183	Nonsense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	1319410	88973183	102181093	26	20546											
PHF17	79960	broad.mit.edu	37	chr4	129792809	129792809	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaagacctttgcagaagcaCgtctcatatcagcacaacag	16	7	7	11	1	2	2	2	0	1	2	3	2	2	2	1	0	4	3	1	0	5	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:129792809C>T	uc003igk.2	+	11	2201	c.1921C>T	c.(1921-1923)CGT>TGT	p.R641C	PHF17_uc003igl.2_Missense_Mutation_p.R629C|PHF17_uc011cgy.1_Missense_Mutation_p.R641C	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	641					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						TGCAGAAGCACGTCTCATATC	0.458													42	70					0	0	0	0	T	129792809	T	T	129792809	3	4	114	1	0	0	0	0	1	0	0	0	11883	536	19	1	1986	1	PHF17	4	129792809	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	40819626	129792809	61361467	27	20547											
ASB5	140458	broad.mit.edu	37	chr4	177142616	177142616	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttacctttactggcggcctCatgcgttggggatggaagac	7	11	14	9	2	1	1	1	0	0	1	1	3	1	3	2	5	3	2	2	5	3	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr4:177142616C>T	uc003iuq.1	-	4	536	c.520G>A	c.(520-522)GAG>AAG	p.E174K	ASB5_uc003iup.1_Missense_Mutation_p.E121K	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	174	ANK 4.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		CTGGCGGCCTCATGCGTTGGG	0.488													68	106					0	0	0	0	T	177142616	T	T	177142616	3	4	114	1	0	0	0	0	1	0	0	0	1028	835	29	2	485	2	ASB5	4	177142616	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	47349807	177142616	14011660	28	20548											
DNAH5	1767	broad.mit.edu	37	chr5	13871017	13871017	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcttcaataagcataaaaatGttttccatctcactccggta	13	14	4	10	1	3	0	2	0	2	0	6	0	5	0	2	1	1	3	2	1	6	6			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr5:13871017G>A	uc003jfd.2	-	24	3735	c.3693C>T	c.(3691-3693)AAC>AAT	p.N1231N		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1231	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCATAAAAATGTTTTCCATCT	0.408									Kartagener_syndrome				37	191					0	0	0	0	A	13871017	A	A	13871017	2	1	114	1	0	0	0	0	0	0	0	1	4626	1368	48	4		4	DNAH5	5	13871017	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08		13871017	167044243	29	20549											
FNIP1	96459	broad.mit.edu	37	chr5	130987626	130987626	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggctactggccacttgaaCagtccatttatccatgtcag	9	12	8	12	0	1	1	1	1	0	0	3	1	3	1	3	2	2	1	3	2	3	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr5:130987626C>G	uc003kvs.1	-	16	3317	c.3175G>C	c.(3175-3177)GTT>CTT	p.V1059L	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.V1031L	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	1059					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		GCCACTTGAACAGTCCATTTA	0.383													30	67					0	0	0	0	G	130987626	G	G	130987626	3	3	114	1	0	0	0	0	1	0	0	0	6007	478	17	4	337	4	FNIP1	5	130987626	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	117116609	130987626	49927634	30	20550											
SLC22A5	6584	broad.mit.edu	37	chr5	131721136	131721136	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacttcatccgagactggCggatgctgctggtggcgctg	5	11	14	11	3	1	1	1	0	0	1	2	3	2	2	1	4	3	3	1	4	1	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr5:131721136C>T	uc003kww.3	+	4	1033	c.769C>T	c.(769-771)CGG>TGG	p.R257W	SLC22A5_uc003kwx.3_Missense_Mutation_p.R281W|SLC22A5_uc010jdr.1_5'UTR	NM_003060	NP_003051	O76082	S22A5_HUMAN	solute carrier family 22 member 5	257	Extracellular (Potential).		R -> W (in CDSP).		positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity				0		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CCGAGACTGGCGGATGCTGCT	0.522											OREG0016766	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	87					0	0	0	0	T	131721136	T	T	131721136	3	4	114	1	0	0	0	0	1	0	0	0	14521	759	27	1	783	1	SLC22A5	5	131721136	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	733510	131721136	49194124	31	20551											
FSTL4	23105	broad.mit.edu	37	chr5	132736645	132736645	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcagaacttcttcccgCaggaggccagcagctcgttg	7	8	13	13	2	1	1	0	0	1	1	3	2	2	2	2	3	4	6	2	3	1	3			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr5:132736645C>A	uc003kyn.1	-	4	412	c.194G>T	c.(193-195)TGC>TTC	p.C65F		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	65						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTCTTCCCGCAGGAGGCCAG	0.627													12	26					3.27435e-08	3.56046e-08	1	0	A	132736645	A	A	132736645	3	1	114	1	0	0	0	0	1	0	0	0	6113	710	25	4	2386	4	FSTL4	5	132736645	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	1015509	132736645	48178615	32	20552											
DOCK2	1794	broad.mit.edu	37	chr5	169508958	169508958	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gacaagaagacactcacacgGaagaaggtcaatcagttctt	16	7	9	9	1	4	3	3	0	1	3	4	5	4	4	0	2	0	1	0	2	5	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr5:169508958G>A	uc003maf.2	+	51	5480	c.5400G>A	c.(5398-5400)CGG>CGA	p.R1800R	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.R1292R|DOCK2_uc003mah.2_Silent_p.R356R	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1800					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CACTCACACGGAAGAAGGTCA	0.527													31	49					0	0	0	0	A	169508958	A	A	169508958	2	1	114	1	0	0	0	0	0	0	0	1	4709	1161	41	2		2	DOCK2	5	169508958	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08	36772313	169508958	11406302	33	20553											
HIST1H4C	8364	broad.mit.edu	37	chr6	26104203	26104203	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcgcggcaaaggcggaaaaGgcttggggaagggtggtgct	9	6	20	6	3	0	0	0	0	0	0	1	2	0	2	0	8	1	3	0	8	4	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr6:26104203G>C	uc003ngi.2	+	1	28	c.28G>C	c.(28-30)GGC>CGC	p.G10R		NM_003542	NP_003533	P62805	H4_HUMAN	histone cluster 1, H4c	10					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						AGGCGGAAAAGGCTTGGGGAA	0.527													33	67					0	0	0	0	C	26104203	C	C	26104203	3	2	114	1	0	0	0	0	1	0	0	0	7206	1000	35	4	30	4	HIST1H4C	6	26104203	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08		26104203	145010864	34	20554											
KIAA0776	23376	broad.mit.edu	37	chr6	96990812	96990812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaggtgggggcaatgccaGagagtacaaaattaaaaaag	18	5	14	4	0	0	1	0	0	0	1	0	3	0	2	1	4	2	2	1	4	7	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr6:96990812G>A	uc003por.2	+	12	1370	c.1322G>A	c.(1321-1323)AGA>AAA	p.R441K	KIAA0776_uc010kck.2_RNA	NM_015323	NP_056138	O94874	UFL1_HUMAN	hypothetical protein LOC23376	441					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)		GGCAATGCCAGAGAGTACAAA	0.378													37	53					0	0	0	0	A	96990812	A	A	96990812	3	1	114	1	0	0	0	0	1	0	0	0	8232	942	33	2	1368	2	KIAA0776	6	96990812	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	70886609	96990812	74124255	35	20555											
RBM16	22828	broad.mit.edu	37	chr6	155145427	155145427	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaccagcatttcctgtgtcGatgccggttcctcctcctgg	4	12	9	16	2	0	0	0	0	0	0	5	1	4	0	7	2	2	2	7	2	0	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr6:155145427G>A	uc003qqa.2	+	18	2218	c.1986G>A	c.(1984-1986)TCG>TCA	p.S662S	RBM16_uc011efj.1_Silent_p.S728S|RBM16_uc011efk.1_Silent_p.S707S|RBM16_uc003qpz.2_Silent_p.S662S|RBM16_uc010kji.2_Silent_p.S683S	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	662	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		TTCCTGTGTCGATGCCGGTTC	0.458													89	202					0	0	0	0	A	155145427	A	A	155145427	2	1	114	1	0	0	0	0	0	0	0	1	13183	1045	37	1		1	RBM16	6	155145427	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08	58154615	155145427	15969640	36	20556											
SLC29A4	222962	broad.mit.edu	37	chr7	5338650	5338650	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggccctggcccccaacgAgtccccaaaggacagcccag	9	2	10	20	2	0	0	0	0	0	0	1	2	1	1	7	3	2	0	7	3	2	0			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr7:5338650A>G	uc003sod.2	+	8	1075	c.914A>G	c.(913-915)GAG>GGG	p.E305G	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Missense_Mutation_p.E305G|SLC29A4_uc003soe.2_Missense_Mutation_p.E291G|SLC29A4_uc010ksw.2_RNA	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	305	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		GCCCCCAACGAGTCCCCAAAG	0.692													4	45					0	0	0	0	G	5338650	G	G	5338650	3	3	114	1	0	0	0	0	1	0	0	0	14601	304	11	5	940	5	SLC29A4	7	5338650	Missense_Mutation	SNP	A	TCGA-CR-5243-01A-01D-1512-08		5338650	153800013	37	20557											
GLI3	2737	broad.mit.edu	37	chr7	42005532	42005532	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgggccgcgtgtaattctGaagcacgagactgcgcttct	7	10	12	12	5	2	2	0	1	2	1	3	3	2	2	1	1	2	3	1	1	2	3			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr7:42005532G>T	uc011kbh.1	-	15	3230	c.3139C>A	c.(3139-3141)CAG>AAG	p.Q1047K	GLI3_uc011kbg.1_Missense_Mutation_p.Q988K	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1047					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GTGTAATTCTGAAGCACGAGA	0.672									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				16	22					1.15088e-07	1.23941e-07	1	0	T	42005532	T	T	42005532	3	4	114	1	0	0	0	0	1	0	0	0	6476	1299	45	2	1607	2	GLI3	7	42005532	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	36666882	42005532	117133131	38	20558											
CLDN15	24146	broad.mit.edu	37	chr7	100877667	100877667	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctatgcctagcaagaggcCgaggaagcccaggaggatgg	11	4	16	10	2	0	1	0	0	0	1	0	5	0	4	3	5	3	2	3	5	4	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr7:100877667C>T	uc003uyg.1	-	2	528	c.274G>A	c.(274-276)GGC>AGC	p.G92S	CLDN15_uc003uyh.1_Missense_Mutation_p.G92S|CLDN15_uc003uyi.2_3'UTR	NM_014343	NP_055158	P56746	CLD15_HUMAN	claudin 15	92	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					AGCAAGAGGCCGAGGAAGCCC	0.647													27	71					0	0	0	0	T	100877667	T	T	100877667	3	4	114	1	0	0	0	0	1	0	0	0	3491	652	23	1	428	1	CLDN15	7	100877667	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	58872135	100877667	58260996	39	20559											
OR2F1	26211	broad.mit.edu	37	chr7	143657530	143657530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtcagtggcttcatcagctCtcctgtgcagactgctatca	7	12	10	12	0	5	1	4	0	1	1	6	1	5	1	1	2	3	4	1	2	1	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr7:143657530C>G	uc003wds.1	+	1	511	c.467C>G	c.(466-468)TCT>TGT	p.S156C		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					TTCATCAGCTCTCCTGTGCAG	0.522													38	68					0	0	0	0	G	143657530	G	G	143657530	3	3	114	1	0	0	0	0	1	0	0	0	11050	913	32	2	469	2	OR2F1	7	143657530	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	42779863	143657530	15481133	40	20560											
OR2A7	401427	broad.mit.edu	37	chr7	143956023	143956023	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtgcagaaggctttcctCtgaacttcccttgattggat	8	13	10	10	0	1	3	0	2	1	1	3	4	3	4	2	3	2	2	2	3	2	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr7:143956023C>T	uc011kuc.1	-	1	699	c.699G>A	c.(697-699)CAG>CAA	p.Q233Q	OR2A9P_uc003wec.1_Intron|uc003wed.2_5'Flank	NM_001005328	NP_001005328	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.14)					AGGCTTTCCTCTGAACTTCCC	0.483													47	268					0	0	0	0	T	143956023	T	T	143956023	2	4	114	1	0	0	0	0	0	0	0	1	11036	912	32	2		2	OR2A7	7	143956023	Silent	SNP	C	TCGA-CR-5243-01A-01D-1512-08	298493	143956023	15182640	41	20561											
C9orf131	138724	broad.mit.edu	37	chr9	35044336	35044336	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacccccagctcttgcaccGgagctgctcagagttagatc	8	8	9	16	1	2	2	1	0	1	2	3	3	2	3	4	1	4	5	4	1	1	2	rs115027328	by1000genomes	TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr9:35044336G>A	uc003zvw.2	+	2	1739	c.1710G>A	c.(1708-1710)CCG>CCA	p.P570P	C9orf131_uc003zvu.2_Silent_p.P522P|C9orf131_uc003zvv.2_Silent_p.P497P|C9orf131_uc003zvx.2_Silent_p.P535P	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	570											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CTCTTGCACCGGAGCTGCTCA	0.527													4	264					0	0	0	0	A	35044336	A	A	35044336	2	1	114	1	0	0	0	0	0	0	0	1	2469	1103	39	1		1	C9orf131	9	35044336	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08		35044336	106169095	42	20562											
FAM120A	23196	broad.mit.edu	37	chr9	96291641	96291641	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctctgcactgtaggcagaaGgctcgtccactgcctcttca	7	11	9	14	1	3	1	1	0	2	1	6	1	4	1	2	2	2	4	2	2	2	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr9:96291641G>A	uc004atw.2	+	9	1538	c.1513G>A	c.(1513-1515)GGC>AGC	p.G505S	FAM120A_uc004atv.2_Missense_Mutation_p.G505S|FAM120A_uc004atx.2_Missense_Mutation_p.G287S|FAM120A_uc004aty.2_Missense_Mutation_p.G286S|FAM120A_uc004atz.2_Missense_Mutation_p.G154S|FAM120A_uc010mrf.1_RNA|FAM120A_uc010mrg.2_5'Flank	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	505						cytoplasm|plasma membrane	RNA binding				0						GTAGGCAGAAGGCTCGTCCAC	0.537													33	37					0	0	0	0	A	96291641	A	A	96291641	3	1	114	1	0	0	0	0	1	0	0	0	5443	1000	35	4	1547	4	FAM120A	9	96291641	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	61247305	96291641	44921790	43	20563											
NOTCH1	4851	broad.mit.edu	37	chr9	139402754	139402754	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggccggtccagccgctgggGcactcgcagcggtactgggt	5	6	17	13	4	0	0	0	0	0	0	2	0	1	0	3	6	3	4	3	6	1	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr9:139402754G>C	uc004chz.2	-	20	3255	c.3255C>G	c.(3253-3255)TGC>TGG	p.C1085W	NOTCH1_uc004cia.1_Missense_Mutation_p.C315W	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1085	Extracellular (Potential).|EGF-like 28.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGCCGCTGGGGCACTCGCAGC	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			36	65					0	0	0	0	C	139402754	C	C	139402754	3	2	114	1	0	0	0	0	1	0	0	0	10601	1195	42	4	4472	4	NOTCH1	9	139402754	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	43111113	139402754	1810677	44	20564											
ARID5B	84159	broad.mit.edu	37	chr10	63852287	63852287	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggaggatttggaccttgTgattgcagggaaaaaggccc	10	9	14	8	0	0	1	0	1	0	0	0	5	0	5	3	5	1	1	3	5	2	3			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr10:63852287T>C	uc001jlt.1	+	10	3091	c.3065T>C	c.(3064-3066)GTG>GCG	p.V1022A		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1022					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					TTGGACCTTGTGATTGCAGGG	0.587													72	113					0	0	0	0	C	63852287	C	C	63852287	3	2	114	1	0	0	0	0	1	0	0	0	922	1696	59	5	3103	5	ARID5B	10	63852287	Missense_Mutation	SNP	T	TCGA-CR-5243-01A-01D-1512-08		63852287	71682460	45	20565											
BTAF1	9044	broad.mit.edu	37	chr10	93719841	93719841	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggatgtgctgctaaaattacTtacacaagaacaatgggaag	16	9	10	6	0	0	1	0	0	0	1	0	3	0	3	0	2	5	2	0	2	8	3			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr10:93719841T>G	uc001khr.2	+	11	1291	c.1193T>G	c.(1192-1194)CTT>CGT	p.L398R	BTAF1_uc001khs.1_Missense_Mutation_p.L68R	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	398	HEAT 1.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				CTAAAATTACTTACACAAGAA	0.393													61	111					0	0	0	0	G	93719841	G	G	93719841	3	3	114	1	0	0	0	0	1	0	0	0	1541	1609	56	5	1235	5	BTAF1	10	93719841	Missense_Mutation	SNP	T	TCGA-CR-5243-01A-01D-1512-08	29867554	93719841	41814906	46	20566											
LDB1	8861	broad.mit.edu	37	chr10	103867955	103867955	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtgcaggggagttgttaaaGctgtcctcgtcgtcaatgcc	8	11	13	9	2	1	0	1	0	0	0	4	1	2	1	2	2	3	4	2	2	3	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr10:103867955G>A	uc009xwz.2	-	11	1474	c.1131C>T	c.(1129-1131)AGC>AGT	p.S377S	LDB1_uc001kuk.3_Silent_p.S341S	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	377					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		AGTTGTTAAAGCTGTCCTCGT	0.622													71	117					0	0	0	0	A	103867955	A	A	103867955	2	1	114	1	0	0	0	0	0	0	0	1	8735	962	34	4		4	LDB1	10	103867955	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08	10148114	103867955	31666792	47	20567											
SLC6A5	9152	broad.mit.edu	37	chr11	20622730	20622730	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccaacagcccggaggcggCggcggcgcagggccacccgg	7	0	18	16	6	0	0	0	0	0	0	0	1	0	1	4	7	3	1	4	7	1	0			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr11:20622730C>T	uc001mqd.2	+	2	332	c.59C>T	c.(58-60)GCG>GTG	p.A20V	SLC6A5_uc009yic.2_5'UTR	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	20	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	CCGGAGGCGGCGGCGGCGCAG	0.652													8	7					0	0	0	0	T	20622730	T	T	20622730	3	4	114	1	0	0	0	0	1	0	0	0	14751	768	27	1	65	1	SLC6A5	11	20622730	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08		20622730	114383786	48	20568											
CD163	9332	broad.mit.edu	37	chr12	7639365	7639365	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatagatctctactctccCagcacagcgacctcctccat	10	10	5	16	1	2	2	0	1	2	1	6	3	4	2	4	0	3	1	4	0	2	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr12:7639365C>A	uc001qsz.3	-	10	2316	c.2188G>T	c.(2188-2190)GGG>TGG	p.G730W	CD163_uc001qta.3_Missense_Mutation_p.G730W|CD163_uc009zfw.2_Missense_Mutation_p.G763W	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	730	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TCTACTCTCCCAGCACAGCGA	0.483													9	205					0.00448238	0.00478121	1	0	A	7639365	A	A	7639365	3	1	114	1	0	0	0	0	1	0	0	0	2982	594	21	4	1310	4	CD163	12	7639365	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08		7639365	126212530	49	20569											
MLL2	8085	broad.mit.edu	37	chr12	49418485	49418485	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttgacagctctccacccCgggcagctgtgggcacagtt	6	10	12	13	1	1	1	0	1	1	0	2	1	1	1	3	2	2	6	3	2	0	3			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr12:49418485C>T	uc001rta.3	-	50	15928	c.15928G>A	c.(15928-15930)GGG>AGG	p.G5310R		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5310	FYR C-terminal.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTCTCCACCCCGGGCAGCTGT	0.582			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			16	20					0	0	0	0	T	49418485	T	T	49418485	3	4	114	1	0	0	0	0	1	0	0	0	9674	652	23	1	705	1	MLL2	12	49418485	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	41779120	49418485	84433410	50	20570											
DIP2B	57609	broad.mit.edu	37	chr12	51072578	51072578	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcttgaatctgccctgcagCgctggggtaccactcaagca	8	9	10	14	1	3	1	1	1	2	0	3	1	3	1	2	2	5	4	2	2	3	2	rs145274091		TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr12:51072578C>T	uc001rwv.2	+	8	1189	c.1033C>T	c.(1033-1035)CGC>TGC	p.R345C	DIP2B_uc001rwu.2_Missense_Mutation_p.R345C|DIP2B_uc009zls.1_Missense_Mutation_p.R227C	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	345						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TGCCCTGCAGCGCTGGGGTAC	0.532													36	64					0	0	0	0	T	51072578	T	T	51072578	3	4	114	1	0	0	0	0	1	0	0	0	4550	768	27	1	1063	1	DIP2B	12	51072578	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	1654093	51072578	82779317	51	20571											
ACVRL1	94	broad.mit.edu	37	chr12	52307464	52307464	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcctgtggcatgtccgacgGaggcaggagaagcagcgtgg	8	5	19	9	3	0	1	0	0	0	1	1	4	1	2	2	6	2	3	2	6	1	0			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr12:52307464G>A	uc001rzj.2	+	4	718	c.435G>A	c.(433-435)CGG>CGA	p.R145R	ACVRL1_uc001rzk.2_Silent_p.R145R|ACVRL1_uc010snm.1_Intron	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	145	Cytoplasmic (Potential).				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	ATGTCCGACGGAGGCAGGAGA	0.662									Hereditary_Hemorrhagic_Telangiectasia				20	28					0	0	0	0	A	52307464	A	A	52307464	2	1	114	1	0	0	0	0	0	0	0	1	225	1161	41	2		2	ACVRL1	12	52307464	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08	1234886	52307464	81544431	52	20572											
MAP3K12	7786	broad.mit.edu	37	chr12	53876860	53876860	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccttgcggtgacgggtcttgCcacggcgactccgtcctggt	3	10	14	14	5	1	1	0	1	1	0	3	2	3	1	4	4	2	0	4	4	0	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr12:53876860C>A	uc001sdm.1	-	12	1726	c.1628G>T	c.(1627-1629)GGC>GTC	p.G543V	MAP3K12_uc001sdn.1_Missense_Mutation_p.G576V	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	543					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						ACGGGTCTTGCCACGGCGACT	0.647													36	40					1.42033e-22	1.63997e-22	1	0	A	53876860	A	A	53876860	3	1	114	1	0	0	0	0	1	0	0	0	9299	739	26	4	967	4	MAP3K12	12	53876860	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	1569396	53876860	79975035	53	20573											
PARP4	143	broad.mit.edu	37	chr13	25068806	25068806	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagttcttcaatgtaattttCaaagtattcacttgcatctt	11	18	4	8	0	5	0	3	0	2	0	5	0	5	0	0	0	1	4	0	0	4	9	rs145170390		TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr13:25068806C>G	uc001upl.2	-	7	752	c.646G>C	c.(646-648)GAA>CAA	p.E216Q	PARP4_uc010tdc.1_Missense_Mutation_p.E216Q	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	216					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		ATGTAATTTTCAAAGTATTCA	0.338													43	17					0	0	0	0	G	25068806	G	G	25068806	3	3	114	1	0	0	0	0	1	0	0	0	11517	835	29	2	4640	2	PARP4	13	25068806	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08		25068806	90101072	54	20574											
SLITRK5	26050	broad.mit.edu	37	chr13	88328310	88328310	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctacgtggggctcttgcagCacatggataaagttgtggag	9	10	14	8	1	1	0	0	0	1	0	1	2	1	2	1	4	3	4	1	4	3	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr13:88328310C>G	uc001vln.2	+	2	886	c.667C>G	c.(667-669)CAC>GAC	p.H223D	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	223	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCTCTTGCAGCACATGGATAA	0.498													4	137					0	0	0	0	G	88328310	G	G	88328310	3	3	114	1	0	0	0	0	1	0	0	0	14810	710	25	4	669	4	SLITRK5	13	88328310	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	63259504	88328310	26841568	55	20575											
ATP11A	23250	broad.mit.edu	37	chr13	113530144	113530144	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcatccagatgctgtccagCgggcccgcctggctggccat	5	9	12	15	2	1	1	1	0	0	1	3	1	3	1	5	3	2	2	5	3	0	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr13:113530144C>T	uc001vsi.3	+	28	3304	c.3216C>T	c.(3214-3216)AGC>AGT	p.S1072S	ATP11A_uc001vsj.3_Silent_p.S1072S|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	1072	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TGCTGTCCAGCGGGCCCGCCT	0.612													69	23					0	0	0	0	T	113530144	T	T	113530144	2	4	114	1	0	0	0	0	0	0	0	1	1121	767	27	1		1	ATP11A	13	113530144	Silent	SNP	C	TCGA-CR-5243-01A-01D-1512-08	25201834	113530144	1639734	56	20576											
CLEC14A	161198	broad.mit.edu	37	chr14	38724510	38724510	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagggacacaacacatcgcCcgagagtttgtcccagcgag	11	5	12	13	3	0	1	0	0	0	1	2	4	1	2	2	1	2	2	2	1	1	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr14:38724510C>A	uc001wum.1	-	1	1065	c.718G>T	c.(718-720)GGC>TGC	p.G240C		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	240	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		AACACATCGCCCGAGAGTTTG	0.622													21	338					6.44725e-10	7.07934e-10	1	0	A	38724510	A	A	38724510	3	1	114	1	0	0	0	0	1	0	0	0	3514	623	22	4	758	4	CLEC14A	14	38724510	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08		38724510	68625030	57	20577											
FSCB	84075	broad.mit.edu	37	chr14	44976120	44976120	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacgatgggtagctttggggCtagatgattttggtatggcc	7	14	15	5	1	0	2	0	1	0	1	0	3	0	2	1	5	2	4	1	5	4	7			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr14:44976120C>A	uc001wvn.2	-	1	380	c.71G>T	c.(70-72)AGC>ATC	p.S24I		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	24						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		AGCTTTGGGGCTAGATGATTT	0.423													145	202					2.99446e-77	3.56786e-77	1	0	A	44976120	A	A	44976120	3	1	114	1	0	0	0	0	1	0	0	0	6100	797	28	4	2410	4	FSCB	14	44976120	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	6251610	44976120	62373420	58	20578											
PELI2	57161	broad.mit.edu	37	chr14	56755238	56755238	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacacggacgaagcccagatCacacagagcaccatatccag	16	3	8	14	2	1	2	1	0	0	2	2	4	2	3	3	1	3	1	3	1	3	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr14:56755238C>T	uc001xch.2	+	4	679	c.393C>T	c.(391-393)ATC>ATT	p.I131I		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	131					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						AAGCCCAGATCACACAGAGCA	0.502													16	26					0	0	0	0	T	56755238	T	T	56755238	2	4	114	1	0	0	0	0	0	0	0	1	11776	816	29	2		2	PELI2	14	56755238	Silent	SNP	C	TCGA-CR-5243-01A-01D-1512-08	11779118	56755238	50594302	59	20579											
LGMN	5641	broad.mit.edu	37	chr14	93182496	93182496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attacctcttcaggactttgCcggatcctatgcccttcact	7	14	6	14	1	3	0	2	0	1	0	4	2	4	2	4	2	3	0	4	2	2	5			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr14:93182496C>T	uc001yav.2	-	6	715	c.389G>A	c.(388-390)GGC>GAC	p.G130D	LGMN_uc001yat.2_Missense_Mutation_p.G130D|LGMN_uc001yau.2_Missense_Mutation_p.G130D|LGMN_uc001yaw.2_Missense_Mutation_p.G130D|LGMN_uc010aul.2_Intron|LGMN_uc001yax.2_Missense_Mutation_p.G130D|LGMN_uc001yay.2_Missense_Mutation_p.G130D	NM_001008530	NP_001008530	Q99538	LGMN_HUMAN	legumain preproprotein	130					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			skin(1)	1		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		CAGGACTTTGCCGGATCCTAT	0.468													4	198					0	0	0	0	T	93182496	T	T	93182496	3	4	114	1	0	0	0	0	1	0	0	0	8796	739	26	4	952	4	LGMN	14	93182496	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	36427258	93182496	14167044	60	20580											
TRAF3	7187	broad.mit.edu	37	chr14	103371927	103371927	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgatggatcaggggtcctctCgacgtcatttgggagatgca	8	11	14	8	2	3	2	2	1	1	1	5	5	4	3	1	4	1	1	1	4	0	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr14:103371927C>T	uc001ymc.1	+	12	1866	c.1513C>T	c.(1513-1515)CGA>TGA	p.R505*	TRAF3_uc001yme.1_Nonsense_Mutation_p.R480*|TRAF3_uc001ymd.1_Nonsense_Mutation_p.R505*|TRAF3_uc010txy.1_Nonsense_Mutation_p.R422*	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	505	MATH.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		GGGGTCCTCTCGACGTCATTT	0.517													161	36					0	0	0	0	T	103371927	T	T	103371927	4	4	114	1	0	0	0	0	0	1	0	0	16506	876	31	1	1551	1	TRAF3	14	103371927	Nonsense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	10189431	103371927	3977613	61	20581											
B2M	567	broad.mit.edu	37	chr15	45003781	45003782	+	Frame_Shift_Del	DEL	CT	-	-																															ccttagctgtgctcgcgctaCtctctctttctggcctggag																										TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr15:45003781_45003782delCT	uc001zuc.2	+	1	97_98	c.37_38delCT	c.(37-39)CTCfs	p.L13fs	B2M_uc010uek.1_Frame_Shift_Del_p.L13fs|B2M_uc010bdx.1_Frame_Shift_Del_p.L13fs	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	13					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GCTCGCGCTACTCTCTCTTTCT	0.614													---	---	---								-	45003782	-	-	45003781	7	5	114	1	0	1	0	1	0	0	0	0	1246	565	20	0	39	0	B2M	15	45003781	Frame_Shift_Del	DEL	CT	TCGA-CR-5243-01A-01D-1512-08		45003781	57527611	62	20582											
MLST8	64223	broad.mit.edu	37	chr16	2258607	2258607	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgggggactcccagtacatCgtcactggtgagccccgccc	6	7	12	16	3	1	1	1	1	0	0	4	2	2	2	4	3	2	1	4	3	1	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr16:2258607C>T	uc002coz.2	+	8	974	c.855C>T	c.(853-855)ATC>ATT	p.I285I	MLST8_uc002coy.2_Silent_p.I285I|MLST8_uc002cpa.2_Silent_p.I101I|MLST8_uc002cpb.2_Silent_p.I284I|MLST8_uc010uvx.1_Silent_p.I219I|MLST8_uc002cpc.2_Silent_p.I285I|MLST8_uc002cpd.2_Silent_p.I219I|MLST8_uc002cpe.2_Silent_p.I285I|MLST8_uc002cpg.2_Silent_p.I304I|MLST8_uc002cph.2_RNA|MLST8_uc002cpf.2_Silent_p.I285I	NM_022372	NP_071767	Q9BVC4	LST8_HUMAN	G protein beta subunit-like	285	WD 7.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding				0						CCCAGTACATCGTCACTGGTG	0.711													46	70					0	0	0	0	T	2258607	T	T	2258607	2	4	114	1	0	0	0	0	0	0	0	1	9687	874	31	1		1	MLST8	16	2258607	Silent	SNP	C	TCGA-CR-5243-01A-01D-1512-08		2258607	88096146	63	20583											
RFWD3	55159	broad.mit.edu	37	chr16	74695298	74695298	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caggagctggctgttgttcgGcatgatttaactgcacctga	8	12	12	9	1	0	2	0	2	0	0	1	3	0	3	1	3	3	6	1	3	1	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr16:74695298G>A	uc002fda.2	-	2	148	c.50C>T	c.(49-51)GCC>GTC	p.A17V	RFWD3_uc010cgq.2_Missense_Mutation_p.A17V	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	17					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						CTGTTGTTCGGCATGATTTAA	0.478													4	224					0	0	0	0	A	74695298	A	A	74695298	3	1	114	1	0	0	0	0	1	0	0	0	13326	1203	42	4	2322	4	RFWD3	16	74695298	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	72436691	74695298	15659455	64	20584											
KDM6B	23135	broad.mit.edu	37	chr17	7751611	7751611	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctgcctgcccgaggccctCgactctttgattttcccccc	4	11	8	18	2	1	1	0	1	1	0	3	3	2	1	6	1	3	1	6	1	0	3			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr17:7751611C>T	uc002giw.1	+	11	2381	c.2005C>T	c.(2005-2007)CGA>TGA	p.R669*	KDM6B_uc002gix.2_5'UTR	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	669	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCGAGGCCCTCGACTCTTTGA	0.647													61	79					0	0	0	0	T	7751611	T	T	7751611	4	4	114	1	0	0	0	0	0	1	0	0	8177	876	31	1	2035	1	KDM6B	17	7751611	Nonsense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08		7751611	73443599	65	20585											
HNF1B	6928	broad.mit.edu	37	chr17	36091723	36091723	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaatgcctcctccttcctgCggtttgcaaaccagttgtag	7	12	10	12	1	0	0	0	0	0	0	3	1	3	1	5	2	4	4	5	2	3	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr17:36091723C>T	uc002hok.3	-	4	1129	c.908G>A	c.(907-909)CGC>CAC	p.R303H	HNF1B_uc010wdi.1_Missense_Mutation_p.R277H|HNF1B_uc010cve.1_Missense_Mutation_p.R111H	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	303	Homeobox; HNF1-type.				endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			CTCCTTCCTGCGGTTTGCAAA	0.607									Hereditary_Prostate_Cancer				59	100					0	0	0	0	T	36091723	T	T	36091723	3	4	114	1	0	0	0	0	1	0	0	0	7291	768	27	1	789	1	HNF1B	17	36091723	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	28340112	36091723	45103487	66	20586											
GRN	2896	broad.mit.edu	37	chr17	42427094	42427094	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttccactgcagtgcagaCgggcgatcctgcttccaaag	8	8	12	13	2	0	1	0	0	0	1	3	2	3	1	3	2	3	4	3	2	1	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr17:42427094C>T	uc002igp.1	+	4	543	c.324C>T	c.(322-324)GAC>GAT	p.D108D	GRN_uc002igq.1_3'UTR|GRN_uc002igr.1_5'Flank	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	108					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GCAGTGCAGACGGGCGATCCT	0.637													18	36					0	0	0	0	T	42427094	T	T	42427094	2	4	114	1	0	0	0	0	0	0	0	1	6843	535	19	1		1	GRN	17	42427094	Silent	SNP	C	TCGA-CR-5243-01A-01D-1512-08	6335371	42427094	38768116	67	20587											
TIMP2	7077	broad.mit.edu	37	chr17	76851860	76851860	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagaacttggcctggtgcccGttgatgttcttctctgtgac	6	14	11	10	1	2	3	0	2	2	1	3	3	2	3	2	2	2	2	2	2	2	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr17:76851860G>A	uc002jwf.2	-	5	854	c.552C>T	c.(550-552)AAC>AAT	p.N184N	TIMP2_uc002jwe.2_Silent_p.N107N|TIMP2_uc010wty.1_Silent_p.N107N	NM_003255	NP_003246	P16035	TIMP2_HUMAN	TIMP metallopeptidase inhibitor 2 precursor	184							metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)			CCTGGTGCCCGTTGATGTTCT	0.632													43	65					0	0	0	0	A	76851860	A	A	76851860	2	1	114	1	0	0	0	0	0	0	0	1	15984	1136	40	1		1	TIMP2	17	76851860	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08	34424766	76851860	4343350	68	20588											
FLJ35220	284131	broad.mit.edu	37	chr17	78389501	78389501	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaccgggacaccgaggcgtgGcagcgagaccccgccttctc	7	4	14	16	5	1	1	0	0	1	1	2	5	1	2	5	3	1	1	5	3	0	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr17:78389501G>A	uc002jym.1	+	2	136	c.108G>A	c.(106-108)TGG>TGA	p.W36*	uc002jyi.1_5'Flank|FLJ35220_uc002jyj.1_Nonsense_Mutation_p.W36*|FLJ35220_uc002jyk.2_Nonsense_Mutation_p.W36*|FLJ35220_uc002jyl.1_Nonsense_Mutation_p.W36*|FLJ35220_uc002jyn.2_5'UTR	NM_173627	NP_775898	Q8N8Q3	ENDOV_HUMAN	hypothetical protein LOC284131 isoform 1	36					DNA repair		endodeoxyribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			CCGAGGCGTGGCAGCGAGACC	0.642								Direct_reversal_of_damage|Editing_and_processing_nucleases					3	20					0	0	0	0	A	78389501	A	A	78389501	4	1	114	1	0	0	0	0	0	1	0	0	5959	1212	42	4	114	4	FLJ35220	17	78389501	Nonsense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	1537641	78389501	2805709	69	20589											
RALBP1	10928	broad.mit.edu	37	chr18	9535827	9535827	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgggggtgccgtccagccGcccagagacggcgtccttga	5	5	16	15	6	0	2	0	1	0	1	2	3	2	2	5	3	2	0	5	3	0	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr18:9535827G>A	uc002kob.2	+	10	2083	c.1860G>A	c.(1858-1860)CCG>CCA	p.P620P	RALBP1_uc002koc.2_Silent_p.P620P	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	620					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1						CCGTCCAGCCGCCCAGAGACG	0.667													6	11					0	0	0	0	A	9535827	A	A	9535827	2	1	114	1	0	0	0	0	0	0	0	1	13077	1074	38	1		1	RALBP1	18	9535827	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08		9535827	68541421	70	20590											
ROCK1	6093	broad.mit.edu	37	chr18	18547018	18547018	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgaagctcattcctatgtGcacattcttctaccaattgc	9	15	5	12	0	4	1	1	1	3	0	5	1	5	1	2	0	4	2	2	0	4	6			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr18:18547018G>A	uc002kte.2	-	27	4153	c.3212C>T	c.(3211-3213)GCA>GTA	p.A1071V		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1071	Potential.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					ATTCCTATGTGCACATTCTTC	0.333													63	96					0	0	0	0	A	18547018	A	A	18547018	3	1	114	1	0	0	0	0	1	0	0	0	13582	1319	46	4	880	4	ROCK1	18	18547018	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	9011191	18547018	59530230	71	20591											
DNM2	1785	broad.mit.edu	37	chr19	10887831	10887831	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcatcaccaagcttgacctGatggacgagggcaccgacgc	10	6	12	13	3	2	2	2	2	0	0	2	5	2	3	3	2	1	2	3	2	1	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:10887831G>C	uc002mps.1	+	5	791	c.627G>C	c.(625-627)CTG>CTC	p.L209L	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.L209L|DNM2_uc002mpv.1_Silent_p.L209L|DNM2_uc002mpu.1_Silent_p.L209L|DNM2_uc010dxl.1_Silent_p.L209L	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	209					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			AGCTTGACCTGATGGACGAGG	0.532													27	60					0	0	0	0	C	10887831	C	C	10887831	2	2	114	1	0	0	0	0	0	0	0	1	4694	1277	45	2		2	DNM2	19	10887831	Silent	SNP	G	TCGA-CR-5243-01A-01D-1512-08		10887831	48241152	72	20592											
ZNF433	163059	broad.mit.edu	37	chr19	12126251	12126251	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccataacccttacattcataCggcttctcttctctgtgcat	8	15	4	14	1	3	0	1	0	2	0	5	0	3	0	2	1	4	2	2	1	3	6			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:12126251C>T	uc002msy.1	-	4	1602	c.1431G>A	c.(1429-1431)CCG>CCA	p.P477P	uc002msx.1_Intron|ZNF433_uc002msz.1_Silent_p.P442P	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	477					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACATTCATACGGCTTCTCTT	0.388													19	41					0	0	0	0	T	12126251	T	T	12126251	2	4	114	1	0	0	0	0	0	0	0	1	17974	523	19	1		1	ZNF433	19	12126251	Silent	SNP	C	TCGA-CR-5243-01A-01D-1512-08	1238420	12126251	47002732	73	20593											
ZNF90	7643	broad.mit.edu	37	chr19	20228642	20228642	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccagagcagagcctaaaagaTtccttccaaaaagtgatagt	16	8	8	9	0	0	4	0	1	0	3	2	4	2	4	4	0	2	1	4	0	5	4			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:20228642T>C	uc002nor.2	+	4	418	c.279T>C	c.(277-279)GAT>GAC	p.D93D	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	93						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GCCTAAAAGATTCCTTCCAAA	0.343													5	24					0	0	0	0	C	20228642	C	C	20228642	2	2	114	1	0	0	0	0	0	0	0	1	18266	1490	52	5		5	ZNF90	19	20228642	Silent	SNP	T	TCGA-CR-5243-01A-01D-1512-08	8102391	20228642	38900341	74	20594											
MAG	4099	broad.mit.edu	37	chr19	35800939	35800939	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagttcgtgtactcggagcGcagcggcctcgtgctcacca	6	8	14	13	5	1	0	1	0	0	0	4	2	1	2	2	3	4	4	2	3	1	2	rs147583558		TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:35800939G>A	uc002nyy.1	+	8	1543	c.1394G>A	c.(1393-1395)CGC>CAC	p.R465H	MAG_uc002nyx.1_Missense_Mutation_p.R465H|MAG_uc010eds.1_Missense_Mutation_p.R440H|MAG_uc002nyz.1_Missense_Mutation_p.R465H	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	465	Ig-like C2-type 4.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TACTCGGAGCGCAGCGGCCTC	0.677													36	64					0	0	0	0	A	35800939	A	A	35800939	3	1	114	1	0	0	0	0	1	0	0	0	9213	1087	38	1	1416	1	MAG	19	35800939	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	15572297	35800939	23328044	75	20595											
ZNF221	7638	broad.mit.edu	37	chr19	44470025	44470025	+	Frame_Shift_Del	DEL	A	-	-																															tgaagagtggtcctgtcagcAaatatgggaacaaattgcaa																										TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:44470025delA	uc002oxx.2	+	6	699	c.371delA	c.(370-372)CAAfs	p.Q124fs	ZNF221_uc010ejb.1_Frame_Shift_Del_p.Q124fs|ZNF221_uc010xws.1_Frame_Shift_Del_p.Q124fs	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				TCCTGTCAGCAAATATGGGAA	0.443													---	---	---								-	44470025	-	-	44470025	7	5	114	1	0	1	0	1	0	0	0	0	17842	130	5	0	385	0	ZNF221	19	44470025	Frame_Shift_Del	DEL	A	TCGA-CR-5243-01A-01D-1512-08	8669086	44470025	14658958	76	20596											
CPT1C	126129	broad.mit.edu	37	chr19	50216294	50216294	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcatgatcaccttccacatCtccagcaaaaaatcaagcac	15	7	5	14	0	3	1	2	1	1	0	5	1	4	1	3	1	2	3	3	1	4	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:50216294C>G	uc002ppj.2	+	18	2404	c.2199C>G	c.(2197-2199)ATC>ATG	p.I733M	CPT1C_uc002ppi.2_Missense_Mutation_p.I650M|CPT1C_uc002ppk.2_Missense_Mutation_p.I722M|CPT1C_uc010eng.2_Missense_Mutation_p.I733M|CPT1C_uc010enh.2_Missense_Mutation_p.I733M|CPT1C_uc010eni.1_Missense_Mutation_p.I301M	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	733	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CCTTCCACATCTCCAGCAAAA	0.313													121	214					0	0	0	0	G	50216294	G	G	50216294	3	3	114	1	0	0	0	0	1	0	0	0	3848	903	32	2	2265	2	CPT1C	19	50216294	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	5746269	50216294	8912689	77	20597											
MYH14	79784	broad.mit.edu	37	chr19	50720993	50720993	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgccaccccacgtgtacgCagtgaccgagggggcctatc	7	6	14	14	3	0	1	0	1	0	0	1	2	0	1	5	3	2	2	5	3	2	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:50720993C>A	uc002prr.1	+	3	574	c.527C>A	c.(526-528)GCA>GAA	p.A176E	MYH14_uc010enu.1_Missense_Mutation_p.A176E|MYH14_uc002prq.1_Missense_Mutation_p.A176E	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	176	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CACGTGTACGCAGTGACCGAG	0.637													42	71					2.56175e-15	2.89814e-15	1	0	A	50720993	A	A	50720993	3	1	114	1	0	0	0	0	1	0	0	0	10086	710	25	4	533	4	MYH14	19	50720993	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	504699	50720993	8407990	78	20598											
ZNF845	91664	broad.mit.edu	37	chr19	53856710	53856710	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaaccttccgtcacaatTcagtccttgtaattcataag	13	12	5	11	1	3	0	3	0	0	0	5	0	5	0	3	0	1	2	3	0	5	6			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr19:53856710T>G	uc010ydv.1	+	4	2899	c.2782T>G	c.(2782-2784)TCA>GCA	p.S928A	ZNF845_uc010ydw.1_Missense_Mutation_p.S928A	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	928	C2H2-type 26.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGTCACAATTCAGTCCTTGT	0.373													14	21					0	0	0	0	G	53856710	G	G	53856710	3	3	114	1	0	0	0	0	1	0	0	0	18258	1783	62	5	2792	5	ZNF845	19	53856710	Missense_Mutation	SNP	T	TCGA-CR-5243-01A-01D-1512-08	3135717	53856710	5272273	79	20599											
ADAM33	80332	broad.mit.edu	37	chr20	3652265	3652265	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtgcctggctctaccaggCccaggccaagcaggtccagc	7	5	14	15	0	1	0	0	0	1	0	2	0	2	0	5	5	4	2	5	5	2	1			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:3652265C>T	uc002wit.2	-	16	1955	c.1868G>A	c.(1867-1869)GGC>GAC	p.G623D	ADAM33_uc002wiq.1_5'Flank|ADAM33_uc002wir.1_Missense_Mutation_p.G623D|ADAM33_uc002wis.2_Missense_Mutation_p.G145D|ADAM33_uc002wiu.2_Missense_Mutation_p.G623D|uc002wiv.1_5'Flank|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Missense_Mutation_p.G139D	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	623	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						CTCTACCAGGCCCAGGCCAAG	0.632													3	29					0	0	0	0	T	3652265	T	T	3652265	3	4	114	1	0	0	0	0	1	0	0	0	250	739	26	4	601	4	ADAM33	20	3652265	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08		3652265	59373255	80	20600											
CDC25B	994	broad.mit.edu	37	chr20	3781917	3781917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acagtgtctcagtcctgaccGgaagatggaagtggaggagc	11	7	15	8	1	1	2	1	1	1	1	3	6	2	6	2	4	1	0	2	4	2	0			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:3781917G>A	uc002wjn.2	+	8	1500	c.722G>A	c.(721-723)CGG>CAG	p.R241Q	CDC25B_uc010zqk.1_Missense_Mutation_p.R177Q|CDC25B_uc010zql.1_Missense_Mutation_p.R163Q|CDC25B_uc010zqm.1_Missense_Mutation_p.R177Q|CDC25B_uc002wjl.2_Missense_Mutation_p.R129Q|CDC25B_uc002wjm.2_Missense_Mutation_p.R129Q|CDC25B_uc002wjo.2_Missense_Mutation_p.R227Q|CDC25B_uc002wjp.2_Missense_Mutation_p.R200Q|CDC25B_uc002wjq.2_Missense_Mutation_p.R41Q|CDC25B_uc010gbc.2_5'Flank	NM_021873	NP_068659	P30305	MPIP2_HUMAN	cell division cycle 25B isoform 1	241					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|ovary(2)	5						AGTCCTGACCGGAAGATGGAA	0.562													5	238					0	0	0	0	A	3781917	A	A	3781917	3	1	114	1	0	0	0	0	1	0	0	0	3078	1116	39	1	752	1	CDC25B	20	3781917	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	129652	3781917	59243603	81	20601											
HAO1	54363	broad.mit.edu	37	chr20	7920988	7920988	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatcatttgccccagaccTgtaatagtcatatatagact	12	14	5	10	0	3	2	3	0	0	2	3	2	3	2	3	0	1	1	3	0	5	7			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:7920988T>C	uc002wmw.1	-	1	106	c.82A>G	c.(82-84)AGG>GGG	p.R28G	HAO1_uc010gbu.2_Missense_Mutation_p.R28G	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	28	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						GCCCCAGACCTGTAATAGTCA	0.313													3	186					0	0	0	0	C	7920988	C	C	7920988	3	2	114	1	0	0	0	0	1	0	0	0	6990	1579	55	5	1062	5	HAO1	20	7920988	Missense_Mutation	SNP	T	TCGA-CR-5243-01A-01D-1512-08	4139071	7920988	55104532	82	20602											
BCL2L1	598	broad.mit.edu	37	chr20	30310086	30310086	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctcactcactgagtctcGtctctggttagtgattctct	5	16	8	12	1	5	2	2	2	3	0	8	2	5	2	0	1	1	2	0	1	1	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:30310086G>A	uc002wwl.2	-	2	302	c.-64C>T	c.(-66--62)GACGA>GATGA		BCL2L1_uc002wwk.2_RNA|BCL2L1_uc002wwm.2_Translation_Start_Site|BCL2L1_uc002wwn.2_Translation_Start_Site|BCL2L1_uc002wwo.1_Translation_Start_Site	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	BCL2-like 1 isoform 1						induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			lung(1)|central_nervous_system(1)	2	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			ACTGAGTCTCGTCTCTGGTTA	0.418													18	68					0	0	0	0	A	30310086	A	A	30310086	1	1	114	1	0	0	0	0	0	0	0	0	1369	1160	40	1		1	BCL2L1	20	30310086	Translation_Start_Site	SNP	G	TCGA-CR-5243-01A-01D-1512-08	22389098	30310086	32715434	83	20603											
PLAGL2	5326	broad.mit.edu	37	chr20	30784277	30784277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actggaatgcttgatggaaaCgaggcagggtggtgctactc	10	9	15	7	1	0	1	0	1	0	0	1	4	0	3	0	5	4	3	0	5	3	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:30784277C>T	uc002wxn.2	-	3	1686	c.1469G>A	c.(1468-1470)CGT>CAT	p.R490H		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	490						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TTGATGGAAACGAGGCAGGGT	0.577													20	142					0	0	0	0	T	30784277	T	T	30784277	3	4	114	1	0	0	0	0	1	0	0	0	12075	536	19	1	25	1	PLAGL2	20	30784277	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	474191	30784277	32241243	84	20604											
PRPF6	24148	broad.mit.edu	37	chr20	62660835	62660835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgacccccatgtgctcctggCcgtggccaagtgagtggggc	5	8	15	13	1	0	2	0	2	0	0	1	2	1	2	5	4	1	1	5	4	1	0			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr20:62660835C>T	uc002yho.2	+	19	2705	c.2537C>T	c.(2536-2538)GCC>GTC	p.A846V	PRPF6_uc002yhp.2_Missense_Mutation_p.A806V	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	846					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GTGCTCCTGGCCGTGGCCAAG	0.587													4	187					0	0	0	0	T	62660835	T	T	62660835	3	4	114	1	0	0	0	0	1	0	0	0	12636	739	26	4	2611	4	PRPF6	20	62660835	Missense_Mutation	SNP	C	TCGA-CR-5243-01A-01D-1512-08	31876558	62660835	364685	85	20605											
TRIOBP	11078	broad.mit.edu	37	chr22	38154082	38154082	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcccctcactgccctgctCaaccaaagccgcggagagcg	8	5	11	17	3	2	1	2	0	0	1	2	2	2	1	5	1	6	1	5	1	2	0			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr22:38154082C>G	uc003atr.2	+	16	6421	c.6150C>G	c.(6148-6150)CTC>CTG	p.L2050L	TRIOBP_uc003atu.2_Silent_p.L1878L|TRIOBP_uc003atv.2_Silent_p.L337L|TRIOBP_uc003atw.2_Silent_p.L337L|TRIOBP_uc003atx.1_5'UTR|TRIOBP_uc010gxh.2_5'UTR	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	2050					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CTGCCCTGCTCAACCAAAGCC	0.642													10	16					0	0	0	0	G	38154082	G	G	38154082	2	3	114	1	0	0	0	0	0	0	0	1	16620	813	29	2		2	TRIOBP	22	38154082	Silent	SNP	C	TCGA-CR-5243-01A-01D-1512-08		38154082	13150484	86	20606											
NCAPH2	29781	broad.mit.edu	37	chr22	50961570	50961570	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccggccttcgaggtgtgtcGttccatgctggcctccctgc	2	11	13	15	3	0	0	0	0	0	0	4	1	2	0	5	3	2	2	5	3	0	2			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chr22:50961570G>C	uc003blr.3	+	19	1774	c.1652G>C	c.(1651-1653)CGT>CCT	p.R551P	NCAPH2_uc003blv.2_Missense_Mutation_p.R551P|NCAPH2_uc010hbb.2_Intron|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Missense_Mutation_p.R552P|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	551					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		GAGGTGTGTCGTTCCATGCTG	0.647													10	14					0	0	0	0	C	50961570	C	C	50961570	3	2	114	1	0	0	0	0	1	0	0	0	10264	1145	40	3	1768	3	NCAPH2	22	50961570	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08	12807488	50961570	342996	87	20607											
PTCHD1	139411	broad.mit.edu	37	chrX	23411520	23411520	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aattttcacattttcaagagGacatcatcttctctaaaaaa	16	14	3	8	0	5	1	3	0	2	1	6	2	5	2	0	1	0	0	0	1	5	6			TCGA-CR-5243-01A-01D-1512-08	TCGA-CR-5243-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	297e8b35-5b8b-4d5b-b812-86165f949a20	20992f4c-7762-48d2-8fb2-8f6eb1763134	g.chrX:23411520G>A	uc004dal.3	+	3	1893	c.1885G>A	c.(1885-1887)GAC>AAC	p.D629N		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	629					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						TTTTCAAGAGGACATCATCTT	0.398													37	64					0	0	0	0	A	23411520	A	A	23411520	3	1	114	1	0	0	0	0	1	0	0	0	12794	1174	41	2	1895	2	PTCHD1	23	23411520	Missense_Mutation	SNP	G	TCGA-CR-5243-01A-01D-1512-08		23411520	131859040	88	20608											
CHD5	26038	broad.mit.edu	37	chr1	6202630	6202632	+	In_Frame_Del	DEL	GAT	-	-																															agtgtgccgcctgtggagtcGatgtaccatggctgcttgtc																										TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:6202630_6202632delGAT	uc001amb.1	-	14	2177_2179	c.2077_2079delATC	c.(2077-2079)ATCdel	p.I693del	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	693					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CTGTGGAGTCGATGTACCATGGC	0.616													---	---	---								-	6202632	-	-	6202630	7	5	115	1	0	1	0	1	0	0	0	0	3343	1048	37	0	3897	0	CHD5	1	6202630	In_Frame_Del	DEL	GAT	TCGA-CR-5247-01A-01D-2012-08		6202630	243047991	1	20609											
HCRTR1	3061	broad.mit.edu	37	chr1	32089283	32089283	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaggaagacagccaagatgCtgatggtggtgctgctggtc	9	8	17	7	0	0	3	0	1	0	2	1	5	0	5	1	5	4	3	1	5	2	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:32089283C>T	uc009vtx.2	+	7	1283	c.898C>T	c.(898-900)CTG>TTG	p.L300L	HCRTR1_uc001btb.2_Silent_p.L125L|HCRTR1_uc001btc.3_Silent_p.L214L|HCRTR1_uc001btd.2_Silent_p.L300L|HCRTR1_uc010ogl.1_Silent_p.L300L	NM_001525	NP_001516	O43613	OX1R_HUMAN	orexin receptor 1	300	Helical; Name=6; (Potential).				feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				ovary(1)	1		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		AGCCAAGATGCTGATGGTGGT	0.632													8	46					0	0	0	0	T	32089283	T	T	32089283	2	4	115	1	0	0	0	0	0	0	0	1	7040	796	28	4		4	HCRTR1	1	32089283	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08	25886653	32089283	217161338	2	20610											
SPOCD1	90853	broad.mit.edu	37	chr1	32263807	32263824	+	Splice_Site	DEL	CCCTTTTCTCCTCCTGGT	-	-																															ccgactgggctcagcactcaCccttttctcctcctggtccc																										TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:32263807_32263824delCCCTTTTCTCCTCCTGGT	uc001bts.1	-	9	2203	c.2145_splice	c.e9+1	p.R715_splice	SPOCD1_uc001btt.2_Splice_Site_p.R21_splice|SPOCD1_uc001btu.2_Splice_Site_p.R715_splice|SPOCD1_uc001btv.2_Splice_Site_p.R208_splice|SPOCD1_uc001btw.1_Splice_Site_p.R59_splice	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1						transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TCAGCACTCACCCTTTTCTCCTCCTGGTCCCGCCAGCG	0.385													---	---	---								-	32263824	-	-	32263807	8	5	115	1	0	1	0	1	0	0	1	0	15144	521	18	0	1536	0	SPOCD1	1	32263807	Splice_Site	DEL	CCCTTTTCTCCTCCTGGT	TCGA-CR-5247-01A-01D-2012-08	174524	32263807	216986814	3	20611											
DLGAP3	58512	broad.mit.edu	37	chr1	35365842	35365842	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctccccatccttgccaccGgtggggtaacccccccagtc	6	8	8	19	1	1	0	0	0	1	0	4	0	2	0	8	3	2	1	8	3	1	2	rs149715442		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:35365842G>A	uc001byc.2	-	2	1140	c.1140C>T	c.(1138-1140)ACC>ACT	p.T380T		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	380					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				CCTTGCCACCGGTGGGGTAAC	0.612													34	122					0	0	0	0	A	35365842	A	A	35365842	2	1	115	1	0	0	0	0	0	0	0	1	4583	1103	39	1		1	DLGAP3	1	35365842	Silent	SNP	G	TCGA-CR-5247-01A-01D-2012-08	3102035	35365842	213884779	4	20612											
LRIG2	9860	broad.mit.edu	37	chr1	113661886	113661886	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acccgggtgatttgctcagaTtgttatgacaatgccaacat	11	12	9	9	1	1	3	1	2	0	1	1	3	1	3	2	1	3	2	2	1	3	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:113661886T>G	uc001edf.1	+	17	2910	c.2712T>G	c.(2710-2712)GAT>GAG	p.D904E	LRIG2_uc009wgn.1_Missense_Mutation_p.D801E	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	904	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TTTGCTCAGATTGTTATGACA	0.413													23	80					0	0	0	0	G	113661886	G	G	113661886	3	3	115	1	0	0	0	0	1	0	0	0	8995	1490	52	5	2778	5	LRIG2	1	113661886	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	78296044	113661886	135588735	5	20613											
SPTA1	6708	broad.mit.edu	37	chr1	158596754	158596754	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttttcattcagagcctctAtcttggaagaaatctctttg	9	17	6	9	0	6	2	2	0	4	2	7	3	6	3	1	1	1	0	1	1	3	6			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:158596754A>G	uc001fst.1	-	41	5907	c.5708T>C	c.(5707-5709)ATA>ACA	p.I1903T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1903	Spectrin 18.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CAGAGCCTCTATCTTGGAAGA	0.428													29	97					0	0	0	0	G	158596754	G	G	158596754	3	3	115	1	0	0	0	0	1	0	0	0	15182	449	16	5	1599	5	SPTA1	1	158596754	Missense_Mutation	SNP	A	TCGA-CR-5247-01A-01D-2012-08	44934868	158596754	90653867	6	20614											
TNFSF4	7292	broad.mit.edu	37	chr1	173155865	173155865	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctggtaatgaaggctaatGttgacttcctgggagaagta	11	13	12	5	0	1	3	0	2	1	1	2	4	2	3	1	3	0	4	1	3	5	6			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:173155865G>A	uc001giw.2	-	3	498	c.342C>T	c.(340-342)AAC>AAT	p.N114N	TNFSF4_uc001giv.2_Silent_p.N64N	NM_003326	NP_003317	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily,	114	Extracellular (Potential).				acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			central_nervous_system(1)	1						GAAGGCTAATGTTGACTTCCT	0.468													13	48					0	0	0	0	A	173155865	A	A	173155865	2	1	115	1	0	0	0	0	0	0	0	1	16376	1368	48	4		4	TNFSF4	1	173155865	Silent	SNP	G	TCGA-CR-5247-01A-01D-2012-08	14559111	173155865	76094756	7	20615											
ASTN1	460	broad.mit.edu	37	chr1	176998825	176998825	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaaaggtcagctgggggtcGttttctgcctctgtgccaga	7	12	13	9	1	3	1	1	0	2	1	4	1	3	1	2	3	3	2	2	3	2	3	rs61758728		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:176998825G>A	uc001glc.2	-	5	1277	c.1065C>T	c.(1063-1065)AAC>AAT	p.N355N	ASTN1_uc001glb.1_Silent_p.N355N|ASTN1_uc001gld.1_Silent_p.N355N|ASTN1_uc009wwx.1_Silent_p.N355N|ASTN1_uc001gle.3_RNA|MIR488_hsa-mir-488|MI0003123_5'Flank	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	355					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GCTGGGGGTCGTTTTCTGCCT	0.507													17	13					0	0	0	0	A	176998825	A	A	176998825	2	1	115	1	0	0	0	0	0	0	0	1	1066	1136	40	1		1	ASTN1	1	176998825	Silent	SNP	G	TCGA-CR-5247-01A-01D-2012-08	3842960	176998825	72251796	8	20616											
FAM5C	339479	broad.mit.edu	37	chr1	190129849	190129849	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgacacctcttgctaaggCtaaaaagcttgtgtacaatt	13	13	7	8	0	1	1	0	1	1	0	1	1	1	1	1	1	3	4	1	1	7	7			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:190129849C>A	uc001gse.1	-	7	1365	c.1133G>T	c.(1132-1134)AGC>ATC	p.S378I	FAM5C_uc010pot.1_Missense_Mutation_p.S276I	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	378						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CTTGCTAAGGCTAAAAAGCTT	0.393													39	44					9.84934e-19	1.1474e-18	1	0	A	190129849	A	A	190129849	3	1	115	1	0	0	0	0	1	0	0	0	5626	797	28	4	1175	4	FAM5C	1	190129849	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	13131024	190129849	59120772	9	20617											
EPHX1	2052	broad.mit.edu	37	chr1	226027611	226027611	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcctcctgggacagcgtttCgggaggtttcttggcctcac	4	12	12	13	2	2	0	1	0	1	0	5	2	4	2	3	4	1	2	3	4	0	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:226027611C>T	uc001hpk.2	+	6	884	c.804C>T	c.(802-804)TTC>TTT	p.F268F	EPHX1_uc001hpl.2_Silent_p.F268F	NM_001136018	NP_001129490	P07099	HYEP_HUMAN	epoxide hydrolase 1	268					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			ovary(3)|lung(1)	4	Breast(184;0.197)					GACAGCGTTTCGGGAGGTTTC	0.552													41	147					0	0	0	0	T	226027611	T	T	226027611	2	4	115	1	0	0	0	0	0	0	0	1	5203	883	31	1		1	EPHX1	1	226027611	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08	35897762	226027611	23223010	10	20618											
DPYSL5	56896	broad.mit.edu	37	chr2	27121496	27121496	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggtgggccgcgagctcatGatccctggcggggccaaggt	6	6	17	12	3	1	1	1	1	0	0	2	2	2	1	3	6	1	1	3	6	1	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:27121496G>C	uc002rhu.3	+	2	287	c.129G>C	c.(127-129)ATG>ATC	p.M43I	DPYSL5_uc002rhv.3_Missense_Mutation_p.M43I	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	43					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGAGCTCATGATCCCTGGCG	0.577													11	90					0	0	0	0	C	27121496	C	C	27121496	3	2	115	1	0	0	0	0	1	0	0	0	4772	1290	45	2	131	2	DPYSL5	2	27121496	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08		27121496	216077877	11	20619											
TSPYL6	388951	broad.mit.edu	37	chr2	54483229	54483229	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgggacctctggccctggtgCgggtcttccagagcatagtc	5	9	14	13	2	2	1	0	0	2	1	4	2	3	2	3	4	2	1	3	4	1	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:54483229C>T	uc002rxr.2	-	1	181	c.60G>A	c.(58-60)CCG>CCA	p.P20P	ACYP2_uc002rxq.3_Intron	NM_001003937	NP_001003937	Q8N831	TSYL6_HUMAN	TSPY-like 6	20					nucleosome assembly	nucleus					0						GGCCCTGGTGCGGGTCTTCCA	0.622													28	124					0	0	0	0	T	54483229	T	T	54483229	2	4	115	1	0	0	0	0	0	0	0	1	16730	755	27	1		1	TSPYL6	2	54483229	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08	27361733	54483229	188716144	12	20620											
REG3G	130120	broad.mit.edu	37	chr2	79254230	79254230	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggctgagggatccttcgtgtCctccctggtgaggagcatta	6	11	14	10	1	0	2	0	2	0	0	4	4	3	4	3	4	1	2	3	4	1	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:79254230C>T	uc002snw.2	+	4	351	c.266C>T	c.(265-267)TCC>TTC	p.S89F	REG3G_uc002snx.2_Missense_Mutation_p.S89F|REG3G_uc010ffu.2_Intron	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	89	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						TCCTTCGTGTCCTCCCTGGTG	0.537													21	106					0	0	0	0	T	79254230	T	T	79254230	3	4	115	1	0	0	0	0	1	0	0	0	13278	855	30	2	276	2	REG3G	2	79254230	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	24771001	79254230	163945143	13	20621											
REV1	51455	broad.mit.edu	37	chr2	100055565	100055565	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaccaagcaatcctgtgtCtttaaggcaccattagagct	11	10	9	11	0	1	1	0	0	1	1	2	1	2	1	3	2	2	4	3	2	4	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:100055565C>T	uc002tad.2	-	6	923	c.711G>A	c.(709-711)AAG>AAA	p.K237K	REV1_uc002tac.2_Silent_p.K237K|REV1_uc002tae.1_Silent_p.K216K	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	237					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						AATCCTGTGTCTTTAAGGCAC	0.512								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					4	34					0	0	0	0	T	100055565	T	T	100055565	2	4	115	1	0	0	0	0	0	0	0	1	13304	912	32	2		2	REV1	2	100055565	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08	20801335	100055565	143143808	14	20622											
IL1R2	7850	broad.mit.edu	37	chr2	102636165	102636165	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agggggaccactcacttactCgtacacgatgtggccctgga	9	8	12	12	2	1	0	1	0	0	0	2	3	1	2	2	4	2	1	2	4	2	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:102636165C>T	uc002tbm.2	+	5	808	c.579C>T	c.(577-579)CTC>CTT	p.L193L	IL1R2_uc002tbn.2_Silent_p.L193L|IL1R2_uc002tbo.1_Silent_p.L193L	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	193	Extracellular (Potential).|Ig-like C2-type 2.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	CTCACTTACTCGTACACGATG	0.418													9	21					0	0	0	0	T	102636165	T	T	102636165	2	4	115	1	0	0	0	0	0	0	0	1	7698	871	31	1		1	IL1R2	2	102636165	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08	2580600	102636165	140563208	15	20623											
RGPD4	285190	broad.mit.edu	37	chr2	108478175	108478175	+	Frame_Shift_Del	DEL	A	-	-																															attttagatgacagtgattcAaatctttcagtggtcaagaa																										TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:108478175delA	uc010ywk.1	+	15	2266	c.2184delA	c.(2182-2184)TCAfs	p.S728fs	RGPD4_uc002tdu.2_5'UTR|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	728					intracellular transport		binding			skin(2)	2						ACAGTGATTCAAATCTTTCAG	0.373													---	---	---								-	108478175	-	-	108478175	7	5	115	1	0	1	0	1	0	0	0	0	13353	117	5	0	2242	0	RGPD4	2	108478175	Frame_Shift_Del	DEL	A	TCGA-CR-5247-01A-01D-2012-08	5842010	108478175	134721198	16	20624											
LCT	3938	broad.mit.edu	37	chr2	136566782	136566782	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtctggaaacaaaagtctgcGtagctgtcaaacaagtcaat	15	9	9	8	1	4	0	2	0	2	0	4	1	4	1	0	1	4	2	0	1	7	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:136566782G>A	uc002tuu.1	-	8	3146	c.3135C>T	c.(3133-3135)TAC>TAT	p.Y1045Y		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1045	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		AAAAGTCTGCGTAGCTGTCAA	0.493													28	55					0	0	0	0	A	136566782	A	A	136566782	2	1	115	1	0	0	0	0	0	0	0	1	8733	1140	40	1		1	LCT	2	136566782	Silent	SNP	G	TCGA-CR-5247-01A-01D-2012-08	28088607	136566782	106632591	17	20625											
MCM6	4175	broad.mit.edu	37	chr2	136610440	136610440	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcaattgattcctcaattcTtgaatgcaaatctactatgc	13	15	4	9	0	4	2	2	2	2	0	5	2	5	2	1	0	3	1	1	0	6	6			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:136610440T>C	uc002tuw.2	-	12	1748	c.1672A>G	c.(1672-1674)AGA>GGA	p.R558G		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	558					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TCCTCAATTCTTGAATGCAAA	0.368													22	38					0	0	0	0	C	136610440	C	C	136610440	3	2	115	1	0	0	0	0	1	0	0	0	9444	1617	56	5	817	5	MCM6	2	136610440	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	43658	136610440	106588933	18	20626											
COL4A4	1286	broad.mit.edu	37	chr2	227966581	227966581	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctataatgaggtacatttacCtttaatcctggaaaacctgg	13	13	7	8	0	0	1	0	1	0	0	1	2	1	2	3	3	3	1	3	3	7	7			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:227966581C>A	uc010zlt.1	-	16	1629	c.975G>T	c.(973-975)AAG>AAT	p.K325N		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	325	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GTACATTTACCTTTAATCCTG	0.318													5	7					0.00116845	0.00132034	1	0	A	227966581	A	A	227966581	3	1	115	1	0	0	0	0	1	0	0	0	3708	695	24	4	4229	4	COL4A4	2	227966581	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	91356141	227966581	15232792	19	20627											
NCL	4691	broad.mit.edu	37	chr2	232326373	232326378	+	In_Frame_Del	DEL	TCCTCG	-	-																															caatttcatcttcatcctcaTcctcgtcctcgtcatcctcc																								rs151176710	byFrequency	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:232326373_232326378delTCCTCG	uc002vru.2	-	3	627_632	c.486_491delCGAGGA	c.(484-492)GACGAGGAT>GAT	p.162_164DED>D	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	162_164	Asp/Glu-rich (acidic).				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		ttcatcctcatcctcgtcctcgtcat	0.262													---	---	---								-	232326378	-	-	232326373	7	5	115	1	0	1	0	1	0	0	0	0	10280	1435	50	0	1689	0	NCL	2	232326373	In_Frame_Del	DEL	TCCTCG	TCGA-CR-5247-01A-01D-2012-08	4359792	232326373	10873000	20	20628											
BSN	8927	broad.mit.edu	37	chr3	49700618	49700618	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacgctcgggacctgggtcGccatgaggcccggccccact	6	5	13	17	4	0	1	0	1	0	0	2	2	0	2	5	4	0	1	5	4	0	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr3:49700618G>T	uc003cxe.3	+	7	11141	c.11027G>T	c.(11026-11028)CGC>CTC	p.R3676L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3676					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GACCTGGGTCGCCATGAGGCC	0.667													8	26					0.00307968	0.0034118	1	0	T	49700618	T	T	49700618	3	4	115	1	0	0	0	0	1	0	0	0	1535	1087	38	3	11053	3	BSN	3	49700618	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08		49700618	148321812	21	20629											
KLHL24	54800	broad.mit.edu	37	chr3	183368865	183368865	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcgttgggtctatcgtgccGttgatctgagaagaccactg	7	12	13	9	3	2	3	0	2	2	2	3	4	2	3	2	1	2	2	2	1	2	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr3:183368865G>A	uc003flv.2	+	3	1016	c.721G>A	c.(721-723)GTT>ATT	p.V241I	KLHL24_uc003flw.2_Missense_Mutation_p.V241I|KLHL24_uc003flx.2_Missense_Mutation_p.V241I	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	241	BACK.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CTATCGTGCCGTTGATCTGAG	0.418													13	53					0	0	0	0	A	183368865	A	A	183368865	3	1	115	1	0	0	0	0	1	0	0	0	8418	1145	40	1	723	1	KLHL24	3	183368865	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	133668247	183368865	14653565	22	20630											
GABRA2	2555	broad.mit.edu	37	chr4	46334667	46334667	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagggccaaaactggtcaCgtagatgttagtgaagactt	13	9	12	7	1	1	3	1	1	0	2	1	4	1	3	1	2	1	2	1	2	5	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:46334667C>T	uc003gxc.3	-	3	893	c.220G>A	c.(220-222)GTG>ATG	p.V74M	GABRA2_uc010igc.2_Missense_Mutation_p.V74M|GABRA2_uc011bzc.1_Intron|GABRA2_uc003gxe.2_Missense_Mutation_p.V74M	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	74	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAACTGGTCACGTAGATGTTA	0.343													14	34					0	0	0	0	T	46334667	T	T	46334667	3	4	115	1	0	0	0	0	1	0	0	0	6195	536	19	1	1163	1	GABRA2	4	46334667	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08		46334667	144819609	23	20631											
LRRC66	339977	broad.mit.edu	37	chr4	52862054	52862054	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaacactgacaggcacacCgccagagccaggtcctgggg	11	4	13	13	1	0	3	0	2	0	1	1	3	1	3	4	4	2	1	4	4	1	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:52862054C>T	uc003gzi.2	-	4	1147	c.1134G>A	c.(1132-1134)GCG>GCA	p.A378A		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	378	Helical; (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						ACAGGCACACCGCCAGAGCCA	0.562													32	59					0	0	0	0	T	52862054	T	T	52862054	2	4	115	1	0	0	0	0	0	0	0	1	9068	639	23	1		1	LRRC66	4	52862054	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08	6527387	52862054	138292222	24	20632											
PCDH10	57575	broad.mit.edu	37	chr4	134071659	134071659	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttaatgacaaccccccctctTtcccggagccagacctgacg	9	8	7	17	2	1	3	0	2	1	1	2	4	2	4	6	1	2	0	6	1	2	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:134071659T>C	uc003iha.2	+	1	1190	c.364T>C	c.(364-366)TTC>CTC	p.F122L	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.F122L	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	122	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CCCCCCCTCTTTCCCGGAGCC	0.612													16	86					0	0	0	0	C	134071659	C	C	134071659	3	2	115	1	0	0	0	0	1	0	0	0	11561	1841	64	5	366	5	PCDH10	4	134071659	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	81209605	134071659	57082617	25	20633											
NPY5R	4889	broad.mit.edu	37	chr4	164271702	164271702	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgatatcttggttgtgctgTtttgctcacctttcacactg	5	18	8	10	0	3	1	2	1	1	0	3	1	3	1	1	1	2	4	1	1	1	6			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:164271702T>C	uc003iqn.2	+	4	459	c.277T>C	c.(277-279)TTT>CTT	p.F93L		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	93	Helical; Name=2; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				GGTTGTGCTGTTTTGCTCACC	0.403													66	148					0	0	0	0	C	164271702	C	C	164271702	3	2	115	1	0	0	0	0	1	0	0	0	10664	1725	60	5	279	5	NPY5R	4	164271702	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	30200043	164271702	26882574	26	20634											
MTRR	4552	broad.mit.edu	37	chr5	7873624	7873624	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgatttctttgctcacctgCggtatgggttactgggtaat	6	17	11	7	1	2	1	1	1	1	0	2	1	2	1	1	3	3	4	1	3	3	6			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:7873624C>T	uc003jed.2	+	3	379	c.349C>T	c.(349-351)CGG>TGG	p.R117W	MTRR_uc010itn.1_Intron|MTRR_uc003jee.3_Missense_Mutation_p.R90W|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_Intron|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	117	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TGCTCACCTGCGGTATGGGTT	0.448													17	69					0	0	0	0	T	7873624	T	T	7873624	3	4	115	1	0	0	0	0	1	0	0	0	10014	759	27	1	359	1	MTRR	5	7873624	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08		7873624	173041636	27	20635											
RNF14	9604	broad.mit.edu	37	chr5	141359811	141359811	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgccagctgcctgtgatgCaggaacctggctgcaccatg	7	8	13	13	0	0	1	0	1	0	0	0	2	0	2	4	2	6	5	4	2	1	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:141359811C>G	uc003lly.2	+	5	997	c.958C>G	c.(958-960)CAG>GAG	p.Q320E	RNF14_uc003llz.2_Missense_Mutation_p.Q320E|RNF14_uc003lma.2_Missense_Mutation_p.Q320E|RNF14_uc003lmb.2_Missense_Mutation_p.Q194E|RNF14_uc003lmc.2_Missense_Mutation_p.Q320E|RNF14_uc011dbg.1_Missense_Mutation_p.Q144E|RNF14_uc011dbh.1_Intron|RNF14_uc003lmd.2_Missense_Mutation_p.Q320E	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	320	IBR-type.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GCCTGTGATGCAGGAACCTGG	0.567													59	31					0	0	0	0	G	141359811	G	G	141359811	3	3	115	1	0	0	0	0	1	0	0	0	13508	711	25	4	972	4	RNF14	5	141359811	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	133486187	141359811	39555449	28	20636											
NSD1	64324	broad.mit.edu	37	chr5	176709563	176709563	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acatgatatcactaatttctAtatgctcaccctagacaaag	15	12	4	10	0	3	2	2	1	1	1	3	2	3	2	1	0	1	1	1	0	6	6			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:176709563A>G	uc003mfr.3	+	19	6128	c.5990A>G	c.(5989-5991)TAT>TGT	p.Y1997C	NSD1_uc003mft.3_Missense_Mutation_p.Y1728C|NSD1_uc011dfx.1_Missense_Mutation_p.Y1645C	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1997	S-adenosyl-L-methionine binding.|SET.		Y -> C (in WES).		negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ACTAATTTCTATATGCTCACC	0.373			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			50	21					0	0	0	0	G	176709563	G	G	176709563	3	3	115	1	0	0	0	0	1	0	0	0	10723	449	16	5	6060	5	NSD1	5	176709563	Missense_Mutation	SNP	A	TCGA-CR-5247-01A-01D-2012-08	35349752	176709563	4205697	29	20637											
HIST1H4E	8367	broad.mit.edu	37	chr6	26204885	26204885	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttggtcatgtctggtcgcGgcaaaggcggaaagggactg	8	9	17	7	3	2	0	1	0	1	0	3	2	2	2	0	6	0	2	0	6	2	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:26204885G>A	uc003ngy.2	+	1	13	c.13G>A	c.(13-15)GGC>AGC	p.G5S		NM_003545	NP_003536	P62805	H4_HUMAN	histone cluster 1, H4e	5					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				GTCTGGTCGCGGCAAAGGCGG	0.517													30	63					0	0	0	0	A	26204885	A	A	26204885	3	1	115	1	0	0	0	0	1	0	0	0	7208	1116	39	1	15	1	HIST1H4E	6	26204885	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08		26204885	144910182	30	20638											
ABCF1	23	broad.mit.edu	37	chr6	30546133	30546133	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtcatttcagtacccgccCcaaaaccccgcggagggaag	10	6	10	15	3	2	0	2	0	0	0	2	2	2	2	5	2	2	1	5	2	4	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:30546133C>A	uc003nql.2	+	5	447	c.352C>A	c.(352-354)CCA>ACA	p.P118T	ABCF1_uc003nqk.2_Missense_Mutation_p.P119T|ABCF1_uc003nqm.2_Missense_Mutation_p.P118T|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	118					inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						AGTACCCGCCCCAAAACCCCG	0.498													4	78					0.00909568	0.00988281	1	0	A	30546133	A	A	30546133	3	1	115	1	0	0	0	0	1	0	0	0	65	623	22	4	370	4	ABCF1	6	30546133	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	4341248	30546133	140568934	31	20639											
AKD1	221264	broad.mit.edu	37	chr6	109962806	109962806	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttaggttcagatatttaagtCgatccataacaatctagatt	14	15	6	6	1	2	2	1	0	1	2	4	3	3	2	1	1	1	1	1	1	6	8	rs148448147	byFrequency	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:109962806C>T	uc003ptn.2	-	10	925	c.848G>A	c.(847-849)CGA>CAA	p.R283Q	AKD1_uc003ptr.3_Missense_Mutation_p.R283Q	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	283					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						ATATTTAAGTCGATCCATAAC	0.348													18	30					0	0	0	0	T	109962806	T	T	109962806	3	4	115	1	0	0	0	0	1	0	0	0	460	884	31	1	5027	1	AKD1	6	109962806	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	79416673	109962806	61152261	32	20640											
TIAM2	26230	broad.mit.edu	37	chr6	155485661	155485661	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaacccaaagagtctccttgCagccgccagccgcccctcca	9	5	8	19	2	1	1	0	0	1	1	3	2	2	1	8	0	4	1	8	0	2	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:155485661C>A	uc003qqb.2	+	10	3414	c.2141C>A	c.(2140-2142)GCA>GAA	p.A714E	TIAM2_uc003qqe.2_Missense_Mutation_p.A714E|TIAM2_uc010kjj.2_Missense_Mutation_p.A247E|TIAM2_uc003qqf.2_Missense_Mutation_p.A66E|TIAM2_uc011efl.1_Missense_Mutation_p.A26E|TIAM2_uc003qqg.2_Missense_Mutation_p.A26E	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	714					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGTCTCCTTGCAGCCGCCAGC	0.552													80	148					5.82419e-33	6.92772e-33	1	0	A	155485661	A	A	155485661	3	1	115	1	0	0	0	0	1	0	0	0	15957	710	25	4	2159	4	TIAM2	6	155485661	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	45522855	155485661	15629406	33	20641											
INTS1	26173	broad.mit.edu	37	chr7	1523641	1523641	+	Missense_Mutation	SNP	A	G	G																															agacctcctcgccctcacccAgctgtagacctcctcgccct																										TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:1523641A>G	uc003skn.2	-	25	3528	c.3427T>C	c.(3427-3429)TGG>CGG	p.W1143R	INTS1_uc003skp.1_Missense_Mutation_p.W490R	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1143					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GCCCTCACCCAGCTGTAGACC	0.687													14	55					0	0	0	0	G	1523641	G	G	1523641	3	3	115	1	0	0	0	0	1	0	0	0	7814	188	7	5	3241	5	INTS1	7	1523641	Missense_Mutation	SNP	A	TCGA-CR-5247-01A-01D-2012-08		1523641	157615022	34	20642	40	2									
INTS1	26173	broad.mit.edu	37	chr7	1523644	1523644	+	Missense_Mutation	SNP	T	C	C																															cctcctcgccctcacccagcTgtagacctcctcgccctcct																										TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:1523644T>C	uc003skn.2	-	25	3525	c.3424A>G	c.(3424-3426)AGC>GGC	p.S1142G	INTS1_uc003skp.1_Missense_Mutation_p.S489G	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1142					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTCACCCAGCTGTAGACCTCC	0.687													14	55					0	0	0	0	C	1523644	C	C	1523644	3	2	115	1	0	0	0	0	1	0	0	0	7814	1580	55	5	3244	5	INTS1	7	1523644	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	3	1523644	157615019	35	20643	40	2									
AHR	196	broad.mit.edu	37	chr7	17382646	17382646	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccacttcatcatccgtcagaAgccagaccttttcctgattt	9	13	5	14	1	3	3	3	1	0	2	5	3	5	3	5	0	1	0	5	0	1	4	rs146912085		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:17382646A>T	uc011jxz.1	+	11	3118	c.2505A>T	c.(2503-2505)GAA>GAT	p.E835D	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	835				LNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGF L -> FK (in Ref. 1; BAA03857).	apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					ATCCGTCAGAAGCCAGACCTT	0.373													77	87					0	0	0	0	T	17382646	T	T	17382646	3	4	115	1	0	0	0	0	1	0	0	0	416	69	3	5	2547	5	AHR	7	17382646	Missense_Mutation	SNP	A	TCGA-CR-5247-01A-01D-2012-08	15859002	17382646	141756017	36	20644											
HDAC9	9734	broad.mit.edu	37	chr7	18975526	18975526	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatctcacagccatctgtgaTgcatcagaagcctgtgtaaa	12	10	9	10	0	3	2	2	1	2	1	4	3	3	2	2	0	3	2	2	0	3	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:18975526T>G	uc003suh.2	+	22	2930	c.2889T>G	c.(2887-2889)GAT>GAG	p.D963E	HDAC9_uc003sue.2_Missense_Mutation_p.D963E|HDAC9_uc003sui.2_Missense_Mutation_p.D966E|HDAC9_uc003suj.2_Missense_Mutation_p.D922E|HDAC9_uc003suk.2_Missense_Mutation_p.D211E	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	963	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CCATCTGTGATGCATCAGAAG	0.438													36	96					0	0	0	0	G	18975526	G	G	18975526	3	3	115	1	0	0	0	0	1	0	0	0	7053	1461	51	5	3097	5	HDAC9	7	18975526	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	1592880	18975526	140163137	37	20645											
KLHL7	55975	broad.mit.edu	37	chr7	23213806	23213806	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacattctcgaatataatacCgaaacagacaaatgggttgc	16	9	7	9	2	1	1	0	0	1	1	2	3	1	1	1	1	3	1	1	1	6	5	rs142565112		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:23213806C>T	uc003svs.3	+	11	1943	c.1650C>T	c.(1648-1650)ACC>ACT	p.T550T	KLHL7_uc003svr.3_Silent_p.T528T|KLHL7_uc011jys.1_Silent_p.T474T|KLHL7_uc011jyt.1_Silent_p.T325T|KLHL7_uc003svt.2_Silent_p.T502T|KLHL7_uc011jyv.1_Silent_p.T280T	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	550	Kelch 6.					Golgi apparatus|nucleolus|plasma membrane					0						AATATAATACCGAAACAGACA	0.423													27	46					0	0	0	0	T	23213806	T	T	23213806	2	4	115	1	0	0	0	0	0	0	0	1	8433	639	23	1		1	KLHL7	7	23213806	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08	4238280	23213806	135924857	38	20646											
ZNF735	730291	broad.mit.edu	37	chr7	63667461	63667461	+	5'Flank	DEL	A	-	-																															caggacgcctccgtaattttAccgggccttttgtgtttctc																										TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:63667461delA	uc011kdn.1	+							NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGTAATTTTACCGGGCCTTT	0.517													---	---	---								-	63667461	-	-	63667461	6	5	115	0	1	1	0	1	0	0	0	0	18191	406	14	0		0	ZNF735	7	63667461	5'Flank	DEL	A	TCGA-CR-5247-01A-01D-2012-08	40453655	63667461	95471202	39	20647											
SRRT	51593	broad.mit.edu	37	chr7	100484575	100484575	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatcaacgtggagcgggatGagaagttgattaaggtgcca	13	8	15	5	2	1	3	1	2	0	2	1	6	1	5	1	3	3	1	1	3	3	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:100484575G>A	uc003uwy.2	+	15	2075	c.1807G>A	c.(1807-1809)GAG>AAG	p.E603K	SRRT_uc010lhl.1_Missense_Mutation_p.E602K|SRRT_uc003uxa.2_Missense_Mutation_p.E602K|SRRT_uc003uwz.2_Missense_Mutation_p.E603K	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	603					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GGAGCGGGATGAGAAGTTGAT	0.647													30	196					0	0	0	0	A	100484575	A	A	100484575	3	1	115	1	0	0	0	0	1	0	0	0	15238	1291	45	2	1857	2	SRRT	7	100484575	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	36817114	100484575	58654088	40	20648											
CUX1	1523	broad.mit.edu	37	chr7	101844779	101844779	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttaaagcaggcaccactgtcCcagagtgacatcaccatcct	12	8	7	14	0	1	2	1	1	0	1	3	2	3	2	4	1	1	2	4	1	2	1	rs150235372		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:101844779C>T	uc003uyx.3	+	18	2240	c.2202C>T	c.(2200-2202)TCC>TCT	p.S734S	CUX1_uc003uys.3_Silent_p.S745S|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	734					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S734S(1)		ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CACCACTGTCCCAGAGTGACA	0.632													22	318					0	0	0	0	T	101844779	T	T	101844779	2	4	115	1	0	0	0	0	0	0	0	1	4081	610	22	4		4	CUX1	7	101844779	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08	1360204	101844779	57293884	41	20649											
TRPS1	7227	broad.mit.edu	37	chr8	116430580	116430580	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtgaagcttctggtagaggCcacacgcgttgcatacatat	11	10	11	9	2	1	2	0	1	1	1	1	2	1	2	1	2	3	4	1	2	4	5			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr8:116430580C>G	uc003ynz.2	-	5	3221	c.2762G>C	c.(2761-2763)GGC>GCC	p.G921A	TRPS1_uc011lhy.1_Missense_Mutation_p.G925A|TRPS1_uc003yny.2_Missense_Mutation_p.G934A|TRPS1_uc010mcy.2_Missense_Mutation_p.G921A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	921					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTGGTAGAGGCCACACGCGTT	0.483									Langer-Giedion_syndrome				137	31					0	0	0	0	G	116430580	G	G	116430580	3	3	115	1	0	0	0	0	1	0	0	0	16660	739	26	4	1091	4	TRPS1	8	116430580	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08		116430580	29933442	42	20650											
FLJ43860	389690	broad.mit.edu	37	chr8	142445304	142445304	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagagggtgtgcagtagccGccagcggagcagcacagcac	11	3	16	11	2	0	1	0	0	0	1	0	3	0	2	2	2	6	5	2	2	2	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr8:142445304G>A	uc003ywi.2	-	29	3682	c.3601C>T	c.(3601-3603)CGG>TGG	p.R1201W	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	1201							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TGCAGTAGCCGCCAGCGGAGC	0.667													56	18					0	0	0	0	A	142445304	A	A	142445304	3	1	115	1	0	0	0	0	1	0	0	0	5962	1086	38	1	371	1	FLJ43860	8	142445304	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	26014724	142445304	3918718	43	20651											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18777750	18777750	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaagatctcagcggcccagCagctctcagcctcggaggtg	8	6	13	14	2	2	1	2	0	2	1	5	2	2	2	2	3	4	3	2	3	1	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:18777750C>A	uc003zne.3	+	19	3650	c.3523C>A	c.(3523-3525)CAG>AAG	p.Q1175K		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1175	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		AGCGGCCCAGCAGCTCTCAGC	0.692													13	15					0.00136819	0.00153075	1	0	A	18777750	A	A	18777750	3	1	115	1	0	0	0	0	1	0	0	0	274	711	25	4	3601	4	ADAMTSL1	9	18777750	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08		18777750	122435681	44	20652											
CDKN2A	1029	broad.mit.edu	37	chr9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcagctccgccactcGggcgctgcccatcatcatga	8	6	10	17	3	2	1	2	1	0	0	4	1	3	1	3	1	4	4	3	1	0	0	rs121913387		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	6					0	0	0	0	A	21971186	A	A	21971186	4	1	115	1	0	0	0	0	0	1	0	0	3176	1125	39	1	306	1	CDKN2A	9	21971186	Nonsense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	3193436	21971186	119242245	45	20653											
GDA	9615	broad.mit.edu	37	chr9	74834409	74834409	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagatttgtgtcagaaaTgctccaaaagaacgtgagta	14	12	9	6	1	2	4	2	1	0	3	3	4	3	4	1	0	2	2	1	0	5	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:74834409T>A	uc004aiq.2	+	6	776	c.593T>A	c.(592-594)ATG>AAG	p.M198K	GDA_uc011lse.1_Missense_Mutation_p.M124K|GDA_uc011lsf.1_Missense_Mutation_p.M124K|GDA_uc004air.2_Missense_Mutation_p.M198K|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Missense_Mutation_p.M156K|GDA_uc004ait.1_Missense_Mutation_p.M124K	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	198					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GTGTCAGAAATGCTCCAAAAG	0.284													10	15					0	0	0	0	A	74834409	A	A	74834409	3	1	115	1	0	0	0	0	1	0	0	0	6342	1464	51	5	615	5	GDA	9	74834409	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	52863223	74834409	66379022	46	20654											
DOLK	22845	broad.mit.edu	37	chr9	131708963	131708963	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagagagcgcttgatgagcTggttgaggacaaagctaatg	12	9	14	6	1	1	4	1	3	0	1	1	6	1	5	0	2	3	4	0	2	2	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:131708963T>G	uc004bwr.2	-	1	1050	c.620A>C	c.(619-621)CAG>CCG	p.Q207P	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	dolichol kinase	207	Helical; (Potential).				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity				0						CTTGATGAGCTGGTTGAGGAC	0.542													40	35					0	0	0	0	G	131708963	G	G	131708963	3	3	115	1	0	0	0	0	1	0	0	0	4725	1580	55	5	1000	5	DOLK	9	131708963	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	56874554	131708963	9504468	47	20655											
FIBCD1	84929	broad.mit.edu	37	chr9	133805423	133805423	+	Frame_Shift_Del	DEL	C	-	-																															cggtgcacagcacgtagccgCagctcggccgctgcaggccc																										TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:133805423delC	uc004bzz.2	-	2	328	c.83delG	c.(82-84)TGCfs	p.C28fs	FIBCD1_uc011mcc.1_Frame_Shift_Del_p.C28fs|FIBCD1_uc011mcd.1_Frame_Shift_Del_p.C36fs	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	28	Cytoplasmic (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CACGTAGCCGCAGCTCGGCCG	0.682													---	---	---								-	133805423	-	-	133805423	7	5	115	1	0	1	0	1	0	0	0	0	5916	710	25	0	1326	0	FIBCD1	9	133805423	Frame_Shift_Del	DEL	C	TCGA-CR-5247-01A-01D-2012-08	2096460	133805423	7408008	48	20656											
TUBAL3	79861	broad.mit.edu	37	chr10	5435651	5435651	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgggcccaggcctccacaatCgccgtggtgttgctcagcat	6	8	12	15	3	1	0	1	0	0	0	3	0	2	0	4	3	2	3	4	3	1	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:5435651C>T	uc001ihy.2	-	4	1210	c.1170G>A	c.(1168-1170)GCG>GCA	p.A390A	TUBAL3_uc001ihz.2_Silent_p.A350A	NM_024803	NP_079079	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	390					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1						CCTCCACAATCGCCGTGGTGT	0.592													31	46					0	0	0	0	T	5435651	T	T	5435651	2	4	115	1	0	0	0	0	0	0	0	1	16819	871	31	1		1	TUBAL3	10	5435651	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08		5435651	130099096	49	20657											
BICC1	80114	broad.mit.edu	37	chr10	60549208	60549208	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtctcagaataacactagtGctgtgaaggtaaattattca	14	12	9	6	0	2	2	2	1	1	1	3	2	2	2	0	2	2	2	0	2	7	5			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:60549208G>A	uc001jki.1	+	7	787	c.787G>A	c.(787-789)GCT>ACT	p.A263T		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	263					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						TAACACTAGTGCTGTGAAGGT	0.328													31	36					0	0	0	0	A	60549208	A	A	60549208	3	1	115	1	0	0	0	0	1	0	0	0	1430	1319	46	4	813	4	BICC1	10	60549208	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	55113557	60549208	74985539	50	20658											
LRRTM3	347731	broad.mit.edu	37	chr10	68686715	68686715	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctactgagcggatcagctgTagcactggttatagccccca	9	9	11	12	1	1	1	1	1	0	0	1	2	1	2	2	2	5	5	2	2	4	4			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:68686715T>C	uc001jmz.1	+	2	591	c.41T>C	c.(40-42)GTA>GCA	p.V14A	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.V14A	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	14						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GGATCAGCTGTAGCACTGGTT	0.413													22	28					0	0	0	0	C	68686715	C	C	68686715	3	2	115	1	0	0	0	0	1	0	0	0	9091	1638	57	5	47	5	LRRTM3	10	68686715	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	8137507	68686715	66848032	51	20659											
OR4C16	219428	broad.mit.edu	37	chr11	55339991	55339991	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatctgtaagcccctgcacTacatgaccatcataagccag	13	8	6	14	0	2	1	1	1	1	0	2	1	2	1	4	0	4	2	4	0	3	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:55339991T>A	uc010rih.1	+	1	388	c.388T>A	c.(388-390)TAC>AAC	p.Y130N		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GCCCCTGCACTACATGACCAT	0.502													61	95					0	0	0	0	A	55339991	A	A	55339991	3	1	115	1	0	0	0	0	1	0	0	0	11103	1522	53	5	390	5	OR4C16	11	55339991	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08		55339991	79666525	52	20660											
OR5L2	26338	broad.mit.edu	37	chr11	55594850	55594850	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actgcactgattcaggtcagCtctcggctccacacccccgt	7	9	8	17	2	3	1	2	1	1	0	5	1	4	1	3	2	2	3	3	2	0	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:55594850C>A	uc001nhy.1	+	1	156	c.156C>A	c.(154-156)AGC>AGA	p.S52R		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TTCAGGTCAGCTCTCGGCTCC	0.478										HNSCC(27;0.073)			101	220					4.49162e-49	5.39951e-49	1	0	A	55594850	A	A	55594850	3	1	115	1	0	0	0	0	1	0	0	0	11225	796	28	4	158	4	OR5L2	11	55594850	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	254859	55594850	79411666	53	20661											
OR8H2	390151	broad.mit.edu	37	chr11	55872323	55872323	+	5'Flank	DEL	G	-	-																															taaacagaaagtttttttttGtttgttttttgttttttgag																								rs113669153		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:55872323delG	uc010riy.1	+							NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					Gtttttttttgtttgtttttt	0.109										HNSCC(53;0.14)			---	---	---								-	55872323	-	-	55872323	6	5	115	0	1	1	0	1	0	0	0	0	11292	1392	48	0		0	OR8H2	11	55872323	5'Flank	DEL	G	TCGA-CR-5247-01A-01D-2012-08	277473	55872323	79134193	54	20662											
MTA2	9219	broad.mit.edu	37	chr11	62362870	62362870	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaagcaggaaagtttgtctgTtcttagccagtagcttggcc	9	12	12	8	0	2	0	0	0	2	0	2	2	2	1	2	2	3	5	2	2	4	5			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:62362870T>C	uc001ntq.1	-	14	1730	c.1349A>G	c.(1348-1350)AAC>AGC	p.N450S	MTA2_uc010rlx.1_Missense_Mutation_p.N277S	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	450					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AGTTTGTCTGTTCTTAGCCAG	0.537													69	71					0	0	0	0	C	62362870	C	C	62362870	3	2	115	1	0	0	0	0	1	0	0	0	9962	1725	60	5	677	5	MTA2	11	62362870	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	6490547	62362870	72643646	55	20663											
FOLR1	2348	broad.mit.edu	37	chr11	71903251	71903253	+	In_Frame_Del	DEL	CTT	-	-																															tgacaacacagctgctgctcCttctagtgtgggtggctgta																										TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:71903251_71903253delCTT	uc001orz.1	+	3	172_174	c.34_36delCTT	c.(34-36)CTTdel	p.L13del	FOLR1_uc001osa.1_In_Frame_Del_p.L13del|FOLR1_uc001osb.1_In_Frame_Del_p.L13del|FOLR1_uc001osc.1_In_Frame_Del_p.L13del|FOLR1_uc001osd.1_In_Frame_Del_p.L13del	NM_016724	NP_057936	P15328	FOLR1_HUMAN	folate receptor 1 precursor	13					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			ovary(1)	1						GCTGCTGCTCCTTCTAGTGTGGG	0.547													---	---	---								-	71903253	-	-	71903251	7	5	115	1	0	1	0	1	0	0	0	0	6013	681	24	0	36	0	FOLR1	11	71903251	In_Frame_Del	DEL	CTT	TCGA-CR-5247-01A-01D-2012-08	9540381	71903251	63103265	56	20664											
PRKRIR	5612	broad.mit.edu	37	chr11	76061960	76061960	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taggaagctctgacttacttGtatagagtttaatatatgtg	12	16	9	4	0	1	2	0	1	1	1	1	3	1	3	0	1	2	3	0	1	8	9			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:76061960G>C	uc001oxh.1	-	5	2234	c.2234C>G	c.(2233-2235)ACA>AGA	p.T745R	PRKRIR_uc010rrz.1_Missense_Mutation_p.T570R	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	745					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity	p.T745R(1)		ovary(2)|pancreas(1)	3						TGACTTACTTGTATAGAGTTT	0.313													6	23					0	0	0	0	C	76061960	C	C	76061960	3	2	115	1	0	0	0	0	1	0	0	0	12588	1377	48	4	55	4	PRKRIR	11	76061960	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	4158709	76061960	58944556	57	20665											
DYNC2H1	79659	broad.mit.edu	37	chr11	102988373	102988373	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttattaggtggttcatttggAaggtttgttcagaaaaagtt	11	17	11	2	0	2	1	2	0	0	1	2	2	2	2	0	4	0	4	0	4	5	7			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:102988373A>T	uc001pho.2	+	6	924	c.780A>T	c.(778-780)GGA>GGT	p.G260G	DYNC2H1_uc001phn.1_Silent_p.G260G|DYNC2H1_uc009yxe.1_Silent_p.G260G	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	260	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GTTCATTTGGAAGGTTTGTTC	0.279													11	356					0	0	0	0	T	102988373	T	T	102988373	2	4	115	1	0	0	0	0	0	0	0	1	4868	233	9	5		5	DYNC2H1	11	102988373	Silent	SNP	A	TCGA-CR-5247-01A-01D-2012-08	26926413	102988373	32018143	58	20666											
H2AFJ	55766	broad.mit.edu	37	chr12	14927722	14927722	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtgaccatcgctcagggCggcgtcctgcccaacatcca	10	6	10	15	3	1	1	1	1	0	0	4	1	3	1	4	2	2	1	4	2	2	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr12:14927722C>T	uc009zia.2	+	1	453	c.318C>T	c.(316-318)GGC>GGT	p.G106G	H2AFJ_uc001rch.3_RNA	NM_177925	NP_808760	Q9BTM1	H2AJ_HUMAN	H2A histone family, member J	106					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1						TCGCTCAGGGCGGCGTCCTGC	0.597													4	108					0	0	0	0	T	14927722	T	T	14927722	2	4	115	1	0	0	0	0	0	0	0	1	6965	755	27	1		1	H2AFJ	12	14927722	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08		14927722	118924173	59	20667											
HELB	92797	broad.mit.edu	37	chr12	66717930	66717930	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcttcctgattttgctaaaaAtaagcgtgactttgaaagta	13	14	8	6	1	0	3	0	3	0	0	1	3	1	3	1	0	2	3	1	0	6	7			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr12:66717930A>G	uc001sti.2	+	10	2493	c.2465A>G	c.(2464-2466)AAT>AGT	p.N822S	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	822					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		TTTGCTAAAAATAAGCGTGAC	0.333													11	42					0	0	0	0	G	66717930	G	G	66717930	3	3	115	1	0	0	0	0	1	0	0	0	7084	101	4	5	2503	5	HELB	12	66717930	Missense_Mutation	SNP	A	TCGA-CR-5247-01A-01D-2012-08	51790208	66717930	67133965	60	20668											
TMEM132D	121256	broad.mit.edu	37	chr12	130185156	130185156	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggaagaaggagacgtccGcgttgttgatgtggtaggtc	9	10	16	6	3	1	3	1	1	0	2	3	5	2	4	1	4	0	3	1	4	3	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr12:130185156G>A	uc009zyl.1	-	2	495	c.167C>T	c.(166-168)GCG>GTG	p.A56V		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	56	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGAGACGTCCGCGTTGTTGAT	0.557													27	36					0	0	0	0	A	130185156	A	A	130185156	3	1	115	1	0	0	0	0	1	0	0	0	16113	1087	38	1	3164	1	TMEM132D	12	130185156	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	63467226	130185156	3666739	61	20669											
PCK2	5106	broad.mit.edu	37	chr14	24572431	24572431	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtttgtgggcagcgccatgCgctctgagtccactgctgca	5	11	13	12	2	1	1	0	1	1	0	2	1	2	1	2	1	4	5	2	1	0	1	rs145351624		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr14:24572431C>T	uc001wlt.2	+	9	1567	c.1435C>T	c.(1435-1437)CGC>TGC	p.R479C	NRL_uc001wlq.2_Intron|PCK2_uc001wlr.1_Missense_Mutation_p.R491C|PCK2_uc010tnw.1_Missense_Mutation_p.R345C|PCK2_uc010tnx.1_Missense_Mutation_p.R345C|PCK2_uc001wlu.3_Intron	NM_004563	NP_004554	Q16822	PCKGM_HUMAN	mitochondrial phosphoenolpyruvate carboxykinase	479					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0184)		CAGCGCCATGCGCTCTGAGTC	0.572													3	26					0	0	0	0	T	24572431	T	T	24572431	3	4	115	1	0	0	0	0	1	0	0	0	11636	768	27	1	1561	1	PCK2	14	24572431	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08		24572431	82777109	62	20670											
NFATC4	4776	broad.mit.edu	37	chr14	24842446	24842446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagatgaaaggaacctgCggcctcatgccttctatcag	10	9	10	12	1	3	2	2	1	1	1	3	3	3	3	3	2	4	1	3	2	3	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr14:24842446C>T	uc001wpc.2	+	4	1750	c.1429C>T	c.(1429-1431)CGG>TGG	p.R477W	NFATC4_uc010tok.1_Missense_Mutation_p.R540W|NFATC4_uc010tol.1_Missense_Mutation_p.R540W|NFATC4_uc010alr.2_Missense_Mutation_p.R540W|NFATC4_uc010als.2_Missense_Mutation_p.R490W|NFATC4_uc010tom.1_Missense_Mutation_p.R490W|NFATC4_uc010ton.1_Missense_Mutation_p.R490W|NFATC4_uc010too.1_Missense_Mutation_p.R490W|NFATC4_uc010alt.2_Missense_Mutation_p.R509W|NFATC4_uc010top.1_Missense_Mutation_p.R509W|NFATC4_uc010toq.1_Missense_Mutation_p.R509W|NFATC4_uc010alu.2_Missense_Mutation_p.R169W|NFATC4_uc010tor.1_Missense_Mutation_p.R477W|NFATC4_uc010tos.1_Missense_Mutation_p.R407W|NFATC4_uc010tot.1_Missense_Mutation_p.R465W|NFATC4_uc010tou.1_Missense_Mutation_p.R407W|NFATC4_uc010tov.1_Missense_Mutation_p.R465W|NFATC4_uc010tow.1_Missense_Mutation_p.R407W|NFATC4_uc010alv.2_Missense_Mutation_p.R465W|NFATC4_uc010tox.1_Missense_Mutation_p.R407W|NFATC4_uc001wpd.2_Missense_Mutation_p.R12W|NFATC4_uc010toy.1_Missense_Mutation_p.R12W|NFATC4_uc010toz.1_Missense_Mutation_p.R12W|NFATC4_uc010tpa.1_5'Flank|NFATC4_uc010tpb.1_5'Flank	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	477	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		AAGGAACCTGCGGCCTCATGC	0.567													12	42					0	0	0	0	T	24842446	T	T	24842446	3	4	115	1	0	0	0	0	1	0	0	0	10419	759	27	1	1636	1	NFATC4	14	24842446	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	270015	24842446	82507094	63	20671											
C14orf49	161176	broad.mit.edu	37	chr14	95921839	95921839	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagctcagcctccagctgctTaatctgctgctcccaggctc	6	10	9	16	0	2	0	1	0	1	0	5	1	4	0	3	1	6	6	3	1	1	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr14:95921839T>G	uc001yei.3	-	5	1027	c.1012A>C	c.(1012-1014)AAG>CAG	p.K338Q	C14orf49_uc010avi.2_Missense_Mutation_p.K338Q|C14orf49_uc001yej.1_Missense_Mutation_p.K338Q	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	338	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		TCCAGCTGCTTAATCTGCTGC	0.667													3	114					0	0	0	0	G	95921839	G	G	95921839	3	3	115	1	0	0	0	0	1	0	0	0	1782	1763	61	5	1967	5	C14orf49	14	95921839	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	71079393	95921839	11427701	64	20672											
HERC2	8924	broad.mit.edu	37	chr15	28389924	28389924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcccctgggatgcgcagctCgctggaccagtcggaccact	7	7	12	15	3	0	0	0	0	0	0	3	3	1	3	4	3	2	3	4	3	0	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr15:28389924C>T	uc001zbj.2	-	72	11141	c.11035G>A	c.(11035-11037)GAG>AAG	p.E3679K		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3679					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATGCGCAGCTCGCTGGACCAG	0.572													15	34					0	0	0	0	T	28389924	T	T	28389924	3	4	115	1	0	0	0	0	1	0	0	0	7097	893	31	1	3557	1	HERC2	15	28389924	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08		28389924	74141468	65	20673											
PPL	5493	broad.mit.edu	37	chr16	4945271	4945272	+	Frame_Shift_Ins	INS	-	T	T																															ccccacgcacctgctcccccINStcaaagtcacagagtgcctc																										TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr16:4945271_4945272insT	uc002cyd.1	-	11	1322_1323	c.1232_1233insA	c.(1231-1233)GAGfs	p.E411fs		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	411	Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						CCTGCTCCCCCTCAAAGTCACA	0.495													---	---	---								T	4945272	T	T	4945271	7	5	115	1	0	1	1	0	0	0	0	0	12394	680	24	0	4085	0	PPL	16	4945271	Frame_Shift_Ins	INS	-	TCGA-CR-5247-01A-01D-2012-08		4945271	85409482	66	20674											
DHX33	56919	broad.mit.edu	37	chr17	5357145	5357145	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcaactggtgcctacctctGgatctctggcacggtcatct	7	11	10	13	1	4	0	1	0	3	0	5	1	4	1	2	4	4	2	2	4	2	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:5357145G>A	uc002gca.2	-	7	1305	c.1303C>T	c.(1303-1305)CAG>TAG	p.Q435*	DHX33_uc002gbz.2_Nonsense_Mutation_p.Q206*|DHX33_uc002gcb.2_Nonsense_Mutation_p.Q262*|DHX33_uc010clf.2_Nonsense_Mutation_p.Q211*	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	435	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						GCCTACCTCTGGATCTCTGGC	0.562													5	41					0	0	0	0	A	5357145	A	A	5357145	4	1	115	1	0	0	0	0	0	1	0	0	4528	1357	47	4	844	4	DHX33	17	5357145	Nonsense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08		5357145	75838065	67	20675											
EPN2	22905	broad.mit.edu	37	chr17	19188962	19188962	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcgctgtgcccccagcacCgcacaggggccccgctgggt	4	5	13	19	3	0	0	0	0	0	0	1	0	0	0	6	3	2	4	6	3	0	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:19188962C>T	uc002gvd.3	+	4	1073	c.625C>T	c.(625-627)CGC>TGC	p.R209C	EPN2_uc010cql.1_Intron|EPN2_uc002gve.3_Intron|EPN2_uc002gvf.3_Intron|EPN2_uc010vyo.1_Intron|EPN2_uc002gvg.1_Intron|EPN2_uc010vyp.1_Intron|EPN2_uc010vyq.1_Intron|EPN2_uc002gvh.1_Missense_Mutation_p.R209C	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	209					endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					cccccagcaccgcacaggggc	0.284													3	10					0	0	0	0	T	19188962	T	T	19188962	3	4	115	1	0	0	0	0	1	0	0	0	5210	652	23	1	631	1	EPN2	17	19188962	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	13831817	19188962	62006248	68	20676											
TLCD1	116238	broad.mit.edu	37	chr17	27051713	27051713	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaatgggtgaggtaggcctGaggggccaggcggaagagaa	12	4	20	5	1	0	3	0	2	0	1	0	6	0	4	2	7	0	1	2	7	4	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:27051713G>C	uc002hco.2	-	4	674	c.559C>G	c.(559-561)CAG>GAG	p.Q187E	TLCD1_uc010waw.1_Missense_Mutation_p.Q140E	NM_138463	NP_612472	Q96CP7	TLCD1_HUMAN	TLC domain containing 1 isoform 1	187	TLC.|Helical; (Potential).					integral to membrane					0	Lung NSC(42;0.00431)					AGGTAGGCCTGAGGGGCCAGG	0.502													7	108					0	0	0	0	C	27051713	C	C	27051713	3	2	115	1	0	0	0	0	1	0	0	0	16003	1299	45	2	188	2	TLCD1	17	27051713	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	7862751	27051713	54143497	69	20677											
AATK	9625	broad.mit.edu	37	chr17	79108261	79108261	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaagacacagccaccacggcGagggaggatggccaggacag	14	1	15	11	2	0	1	0	0	0	1	0	5	0	4	3	5	1	0	3	5	1	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:79108261G>A	uc010dia.2	-	2	176	c.96C>T	c.(94-96)CTC>CTT	p.L32L	MIR1250_hsa-mir-1250|MI0006385_5'Flank	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	32	Helical; (Potential).					integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CCACCACGGCGAGGGAGGATG	0.677													16	25					0	0	0	0	A	79108261	A	A	79108261	2	1	115	1	0	0	0	0	0	0	0	1	26	1045	37	1		1	AATK	17	79108261	Silent	SNP	G	TCGA-CR-5247-01A-01D-2012-08	52056548	79108261	2086949	70	20678											
ZNF24	7572	broad.mit.edu	37	chr18	32917689	32917689	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attctaatgctgaaggaagcTcctgctttggagctagtgct	9	13	11	8	0	1	1	0	1	1	0	2	3	2	3	1	2	5	5	1	2	4	4			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr18:32917689T>C	uc002kyt.2	-	4	771	c.614A>G	c.(613-615)GAG>GGG	p.E205G	ZNF24_uc002kys.2_Missense_Mutation_p.E205G	NM_006965	NP_008896	P17028	ZNF24_HUMAN	zinc finger protein 24	205					myelination|negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGAAGGAAGCTCCTGCTTTGG	0.388													56	42					0	0	0	0	C	32917689	C	C	32917689	3	2	115	1	0	0	0	0	1	0	0	0	17859	1551	54	5	496	5	ZNF24	18	32917689	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08		32917689	45159559	71	20679											
NEDD4L	23327	broad.mit.edu	37	chr18	55996286	55996286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaccaggaggcagcacaccGgcgcttccgctcccgcaggc	8	3	12	18	4	0	0	0	0	0	0	2	1	2	1	4	4	2	5	4	4	1	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr18:55996286G>A	uc002lgy.2	+	10	1014	c.740G>A	c.(739-741)CGG>CAG	p.R247Q	NEDD4L_uc002lgz.2_Missense_Mutation_p.R247Q|NEDD4L_uc002lgx.2_Missense_Mutation_p.R247Q|NEDD4L_uc010xee.1_Missense_Mutation_p.R126Q|NEDD4L_uc002lhc.2_Missense_Mutation_p.R239Q|NEDD4L_uc002lhd.2_Missense_Mutation_p.R126Q|NEDD4L_uc002lhb.2_Missense_Mutation_p.R126Q|NEDD4L_uc002lhe.2_Missense_Mutation_p.R239Q|NEDD4L_uc002lhf.2_Missense_Mutation_p.R126Q|NEDD4L_uc002lhg.2_Missense_Mutation_p.R126Q|NEDD4L_uc002lhh.2_Missense_Mutation_p.R126Q|NEDD4L_uc010dpm.1_Missense_Mutation_p.R98Q	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	247					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						GCAGCACACCGGCGCTTCCGC	0.602													22	14					0	0	0	0	A	55996286	A	A	55996286	3	1	115	1	0	0	0	0	1	0	0	0	10365	1116	39	1	806	1	NEDD4L	18	55996286	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	23078597	55996286	22080962	72	20680											
TLE6	79816	broad.mit.edu	37	chr19	2987144	2987144	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacccagctgttctgggacaAggagccttggttttggcacg	7	10	14	10	1	1	0	0	0	1	0	1	3	1	2	2	4	2	4	2	4	1	4			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:2987144A>G	uc002lwu.2	+	6	480	c.80A>G	c.(79-81)AAG>AGG	p.K27R	TLE6_uc002lwt.2_Missense_Mutation_p.K150R|TLE6_uc010dtg.2_Missense_Mutation_p.K150R|TLE6_uc002lwv.2_5'Flank	NM_024760	NP_079036	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 isoform 2	27					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTGGGACAAGGAGCCTTGG	0.597													19	89					0	0	0	0	G	2987144	G	G	2987144	3	3	115	1	0	0	0	0	1	0	0	0	16008	72	3	5	471	5	TLE6	19	2987144	Missense_Mutation	SNP	A	TCGA-CR-5247-01A-01D-2012-08		2987144	56141839	73	20681											
CCDC124	115098	broad.mit.edu	37	chr19	18053527	18053529	+	In_Frame_Del	DEL	GGA	-	-																															aaggagacgcagcgcctactGgaggaggaggactccaagct																										TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:18053527_18053529delGGA	uc010xpz.1	+	3	267_269	c.222_224delGGA	c.(220-225)CTGGAG>CTG	p.E77del	CCDC124_uc002nhs.2_In_Frame_Del_p.E77del	NM_001136203	NP_001129675	Q96CT7	CC124_HUMAN	coiled-coil domain containing 124	77	Potential.						DNA binding				0						AGCGCCTACTGGAGGAGGAGGAC	0.675													---	---	---								-	18053529	-	-	18053527	7	5	115	1	0	1	0	1	0	0	0	0	2772	1335	47	0	228	0	CCDC124	19	18053527	In_Frame_Del	DEL	GGA	TCGA-CR-5247-01A-01D-2012-08	15066383	18053527	41075456	74	20682											
ZNF208	7757	broad.mit.edu	37	chr19	22156143	22156143	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgataactaagggttgaggAccacttataggctttgccac	12	11	10	8	0	0	2	0	2	0	0	0	3	0	3	2	3	2	2	2	3	4	6	rs112237751		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:22156143A>G	uc002nqp.2	-	5	1542	c.1393T>C	c.(1393-1395)TCC>CCC	p.S465P	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGGGTTGAGGACCACTTATAG	0.348													3	56					0	0	0	0	G	22156143	G	G	22156143	3	3	115	1	0	0	0	0	1	0	0	0	17833	275	10	5	2153	5	ZNF208	19	22156143	Missense_Mutation	SNP	A	TCGA-CR-5247-01A-01D-2012-08	4102616	22156143	36972840	75	20683											
WDR62	284403	broad.mit.edu	37	chr19	36550887	36550887	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctgtgtggtggtgatttTggaccccaaggagaacaagc	10	9	14	8	0	0	2	0	1	0	1	0	4	0	3	2	4	3	1	2	4	3	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:36550887T>G	uc002odc.2	+	3	378	c.287T>G	c.(286-288)TTG>TGG	p.L96W	WDR62_uc002odd.2_Missense_Mutation_p.L96W|WDR62_uc010eer.2_Missense_Mutation_p.L96W|WDR62_uc002odb.2_Missense_Mutation_p.L96W	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	96					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GTGGTGATTTTGGACCCCAAG	0.582													3	156					0	0	0	0	G	36550887	G	G	36550887	3	3	115	1	0	0	0	0	1	0	0	0	17381	1821	63	5	297	5	WDR62	19	36550887	Missense_Mutation	SNP	T	TCGA-CR-5247-01A-01D-2012-08	14394744	36550887	22578096	76	20684											
ZNF420	147923	broad.mit.edu	37	chr19	37619779	37619780	+	Frame_Shift_Ins	INS	-	T	T																															gcctttactcagagttcacaINStctttctcggcatcagagaa																								rs142983916	by1000genomes	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:37619779_37619780insT	uc002ofl.2	+	5	2101_2102	c.1886_1887insT	c.(1885-1887)CATfs	p.H629fs		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	629	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGAGTTCACATCTTTCTCGGC	0.426													---	---	---								T	37619780	T	T	37619779	7	5	115	1	0	1	1	0	0	0	0	0	17964	217	8	0	1896	0	ZNF420	19	37619779	Frame_Shift_Ins	INS	-	TCGA-CR-5247-01A-01D-2012-08	1068892	37619779	21509204	77	20685											
EID2	163126	broad.mit.edu	37	chr19	40030302	40030302	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtgggtggcggagacggaGatagggcaacgcagccaggc	11	3	19	8	3	0	2	0	0	0	2	0	4	0	2	1	6	2	2	1	6	3	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:40030302G>A	uc002oma.2	-	1	537	c.418C>T	c.(418-420)CTC>TTC	p.L140F		NM_153232	NP_694964	Q8N6I1	EID2_HUMAN	CREBBP/EP300 inhibitor 2	140					cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding				0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CGGAGACGGAGATAGGGCAAC	0.602													24	102					0	0	0	0	A	40030302	A	A	40030302	3	1	115	1	0	0	0	0	1	0	0	0	5009	942	33	2	296	2	EID2	19	40030302	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	2410523	40030302	19098681	78	20686											
ZNF780A	284323	broad.mit.edu	37	chr19	40581529	40581529	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttacattcatatggttttaCaccagaatgaatactctgat	13	15	5	8	0	2	3	1	2	1	1	2	3	2	3	1	1	3	1	1	1	6	6			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:40581529C>T	uc002omy.2	-	6	1045	c.820G>A	c.(820-822)GTA>ATA	p.V274I	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.V274I|ZNF780A_uc010xvh.1_Missense_Mutation_p.V275I	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TATGGTTTTACACCAGAATGA	0.388													5	219					0	0	0	0	T	40581529	T	T	40581529	3	4	115	1	0	0	0	0	1	0	0	0	18219	478	17	4	1236	4	ZNF780A	19	40581529	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	551227	40581529	18547454	79	20687											
POLD1	5424	broad.mit.edu	37	chr19	50906777	50906777	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccaccttcatccgtatcatgGaccccgacgtgatcaccggt	8	9	8	16	4	3	1	3	1	0	0	4	3	4	2	6	2	0	1	6	2	1	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:50906777G>C	uc002psb.3	+	10	1221	c.1165G>C	c.(1165-1167)GAC>CAC	p.D389H	POLD1_uc002psc.3_Missense_Mutation_p.D389H|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.D389H	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	389					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CCGTATCATGGACCCCGACGT	0.597								DNA_polymerases_(catalytic_subunits)					19	138					0	0	0	0	C	50906777	C	C	50906777	3	2	115	1	0	0	0	0	1	0	0	0	12245	1174	41	2	1199	2	POLD1	19	50906777	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	10325248	50906777	8222206	80	20688											
LILRB4	11006	broad.mit.edu	37	chr19	55175317	55175317	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggaggctcgggagtaccGtctggataaagaggaaagcc	11	6	15	9	2	1	1	0	0	1	1	2	5	1	5	3	5	2	2	3	5	4	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:55175317G>C	uc002qgp.2	+	3	538	c.176G>C	c.(175-177)CGT>CCT	p.R59P	LILRB4_uc002qgo.1_Missense_Mutation_p.R100P|LILRB4_uc002qgq.2_Missense_Mutation_p.R59P|LILRB4_uc010ers.1_5'UTR|LILRB4_uc002qgr.2_Missense_Mutation_p.R100P|LILRB4_uc010ert.2_Missense_Mutation_p.R100P|LILRB4_uc010eru.2_Missense_Mutation_p.R88P	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	59	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		CGGGAGTACCGTCTGGATAAA	0.587													37	118					0	0	0	0	C	55175317	C	C	55175317	3	2	115	1	0	0	0	0	1	0	0	0	8834	1145	40	3	186	3	LILRB4	19	55175317	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	4268540	55175317	3953666	81	20689											
TBC1D20	128637	broad.mit.edu	37	chr20	420957	420957	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtcatataaccgcacgaCgtgcctgaagtcagacagga	14	6	11	10	3	2	2	2	1	0	1	2	5	2	3	2	1	2	1	2	1	4	2			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr20:420957C>T	uc002wds.2	-	6	841	c.703G>A	c.(703-705)GTC>ATC	p.V235I	TBC1D20_uc002wdv.2_Missense_Mutation_p.V58I|TBC1D20_uc002wdt.2_RNA|TBC1D20_uc002wdu.2_RNA	NM_144628	NP_653229	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	235	Rab-GAP TBC.				interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)	1		all_epithelial(17;0.228)|Breast(17;0.231)				AACCGCACGACGTGCCTGAAG	0.557													8	48					0	0	0	0	T	420957	T	T	420957	3	4	115	1	0	0	0	0	1	0	0	0	15675	536	19	1	520	1	TBC1D20	20	420957	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08		420957	62604563	82	20690											
SIRPG	55423	broad.mit.edu	37	chr20	1629753	1629753	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aactccacgttctcagggctCccttttcgaaacttcacaca	10	11	5	15	2	2	0	2	0	1	0	6	1	4	0	2	1	2	2	2	1	2	4			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr20:1629753C>T	uc002wfm.1	-	2	440	c.375G>A	c.(373-375)GGG>GGA	p.G125G	SIRPG_uc002wfn.1_Silent_p.G125G|SIRPG_uc002wfo.1_Silent_p.G125G	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	125	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						TCTCAGGGCTCCCTTTTCGAA	0.498													55	83					0	0	0	0	T	1629753	T	T	1629753	2	4	115	1	0	0	0	0	0	0	0	1	14401	842	30	2		2	SIRPG	20	1629753	Silent	SNP	C	TCGA-CR-5247-01A-01D-2012-08	1208796	1629753	61395767	83	20691											
ZBP1	81030	broad.mit.edu	37	chr20	56191333	56191333	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccagctctgcaggaccctCgccttcaggatcagtcccgc	6	7	11	17	2	3	0	2	0	1	0	5	2	4	2	4	3	2	2	4	3	0	1			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr20:56191333C>T	uc002xyo.2	-	2	507	c.226G>A	c.(226-228)GAG>AAG	p.E76K	ZBP1_uc010gjm.2_Missense_Mutation_p.E76K|ZBP1_uc002xyp.2_Intron|ZBP1_uc010zzn.1_Missense_Mutation_p.E76K	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	76						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GCAGGACCCTCGCCTTCAGGA	0.527													15	43					0	0	0	0	T	56191333	T	T	56191333	3	4	115	1	0	0	0	0	1	0	0	0	17588	893	31	1	1168	1	ZBP1	20	56191333	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	54561580	56191333	6834187	84	20692											
DMD	1756	broad.mit.edu	37	chrX	31838157	31838157	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccctcagctcttgaagtaaaCggtttaccgccttccactca	9	11	6	15	2	3	1	2	1	1	0	4	1	4	1	4	1	3	3	4	1	4	5			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:31838157C>T	uc004dda.1	-	50	7488	c.7244G>A	c.(7243-7245)CGT>CAT	p.R2415H	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.R1071H|DMD_uc004dcx.2_Missense_Mutation_p.R1074H|DMD_uc004dcz.2_Missense_Mutation_p.R2292H|DMD_uc004dcy.1_Missense_Mutation_p.R2411H|DMD_uc004ddb.1_Missense_Mutation_p.R2407H|DMD_uc004ddd.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2415					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTGAAGTAAACGGTTTACCGC	0.428													20	12					0	0	0	0	T	31838157	T	T	31838157	3	4	115	1	0	0	0	0	1	0	0	0	4602	536	19	1	4081	1	DMD	23	31838157	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08		31838157	123432403	85	20693											
PCDH11X	27328	broad.mit.edu	37	chrX	91873697	91873697	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccacaggttattgccctcCatcgtagtcaggcccaatca	9	10	8	14	1	2	0	2	0	0	0	4	0	3	0	4	2	2	2	4	2	3	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:91873697C>A	uc004efk.1	+	7	4647	c.3802C>A	c.(3802-3804)CAT>AAT	p.H1268N	PCDH11X_uc004efl.1_Missense_Mutation_p.H1258N|PCDH11X_uc004efo.1_Missense_Mutation_p.H1231N|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.H1260N|PCDH11X_uc004efn.1_Missense_Mutation_p.H1250N	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1268	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TATTGCCCTCCATCGTAGTCA	0.562													73	83					2.81854e-13	3.24994e-13	1	0	A	91873697	A	A	91873697	3	1	115	1	0	0	0	0	1	0	0	0	11562	594	21	4	3950	4	PCDH11X	23	91873697	Missense_Mutation	SNP	C	TCGA-CR-5247-01A-01D-2012-08	60035540	91873697	63396863	86	20694											
CHRDL1	91851	broad.mit.edu	37	chrX	109943927	109943927	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagatatcaccatcagaatgTtcccatgacagttctccatc	13	11	5	12	0	3	3	2	1	1	2	6	3	4	3	3	0	0	2	3	0	3	3			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:109943927T>C	uc004eou.3	-	7	913	c.564A>G	c.(562-564)GAA>GAG	p.E188E	CHRDL1_uc004eov.2_Silent_p.E182E|CHRDL1_uc004eow.2_Silent_p.E187E|CHRDL1_uc010nps.2_Silent_p.E187E|CHRDL1_uc004eot.2_Silent_p.E108E|CHRDL1_uc011mss.1_Silent_p.E102E	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	181					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						CATCAGAATGTTCCCATGACA	0.403													12	28					0	0	0	0	C	109943927	C	C	109943927	2	2	115	1	0	0	0	0	0	0	0	1	3388	1722	60	5		5	CHRDL1	23	109943927	Silent	SNP	T	TCGA-CR-5247-01A-01D-2012-08	18070230	109943927	45326633	87	20695											
ARHGAP36	158763	broad.mit.edu	37	chrX	130218231	130218231	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctgagctggaagacggaGccctgctgctgcagaccctg	7	7	15	12	1	0	3	0	1	0	2	0	5	0	5	2	3	5	5	2	3	1	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:130218231G>T	uc004evz.2	+	5	943	c.598G>T	c.(598-600)GCC>TCC	p.A200S	ARHGAP36_uc004ewa.2_Missense_Mutation_p.A188S|ARHGAP36_uc004ewb.2_Missense_Mutation_p.A169S|ARHGAP36_uc004ewc.2_Missense_Mutation_p.A64S	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	200					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						GGAAGACGGAGCCCTGCTGCT	0.463													13	9					1.5842e-08	1.80823e-08	1	0	T	130218231	T	T	130218231	3	4	115	1	0	0	0	0	1	0	0	0	883	971	34	4	612	4	ARHGAP36	23	130218231	Missense_Mutation	SNP	G	TCGA-CR-5247-01A-01D-2012-08	20274304	130218231	25052329	88	20696											
IL9R	3581	broad.mit.edu	37	chrX	155233408	155233408	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgcaccgtcgtgctgccAcctgaggcagtgctcgtgcc	5	8	14	14	3	0	1	0	1	0	0	2	2	0	1	4	1	5	4	4	1	0	0			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:155233408A>G	uc004fnv.1	+	4	500	c.321A>G	c.(319-321)CCA>CCG	p.P107P	IL9R_uc010nvn.2_Silent_p.P86P|IL9R_uc004fnu.1_Missense_Mutation_p.H152R	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	107	Extracellular (Potential).				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TCGTGCTGCCACCTGAGGCAG	0.607													9	19					0	0	0	0	G	155233408	G	G	155233408	2	3	115	1	0	0	0	0	0	0	0	1	7747	146	6	5		5	IL9R	23	155233408	Silent	SNP	A	TCGA-CR-5247-01A-01D-2012-08	25015177	155233408	37152	89	20697											
MRPL20	55052	broad.mit.edu	37	chr1	1341194	1341194	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catactcacccataccttaaCtaaattcccaatgagcgctg	13	10	4	14	1	1	1	1	1	0	0	2	1	2	1	3	0	4	1	3	0	6	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:1341194C>G	uc001afo.3	-	3	367	c.271G>C	c.(271-273)GTT>CTT	p.V91L	MRPL20_uc010nyn.1_Missense_Mutation_p.V91L	NM_017971	NP_060441	Q9BYC9	RM20_HUMAN	mitochondrial ribosomal protein L20 precursor	91							protein binding|rRNA binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CATACCTTAACTAAATTCCCA	0.333													40	130					0	0	0	0	G	1341194	G	G	1341194	3	3	116	1	0	0	0	0	1	0	0	0	9839	565	20	4	186	4	MRPL20	1	1341194	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		1341194	247909427	1	20698											
UTS2	10911	broad.mit.edu	37	chr1	7913473	7913473	+	5'Flank	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgacgcagagcataagatGaaatacgttggtttccattt	13	12	10	6	2	0	4	0	2	0	2	1	4	1	4	1	1	2	4	1	1	3	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:7913473G>T	uc001aor.2	-						UTS2_uc001aoq.2_5'UTR|UTS2_uc001aos.2_Missense_Mutation_p.H7N	NM_006786	NP_006777	O95399	UTS2_HUMAN	urotensin 2 isoform b preproprotein						muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity				0	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		AGCATAAGATGAAATACGTTG	0.413													6	46					3.09899e-07	4.2785e-07	1	0	T	7913473	T	T	7913473	1	4	116	0	1	0	0	0	0	0	0	0	17172	1290	45	2		2	UTS2	1	7913473	5'Flank	SNP	G	TCGA-CR-5248-01A-01D-2012-08	6572279	7913473	241337148	2	20699											
SPEN	23013	broad.mit.edu	37	chr1	16261424	16261424	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cccagacatataatgcctctCctgtgatttcgtctgtgaag	9	13	8	11	1	2	3	0	2	2	1	4	3	2	3	3	0	1	0	3	0	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:16261424C>G	uc001axk.1	+	11	8893	c.8689C>G	c.(8689-8691)CCT>GCT	p.P2897A	SPEN_uc010obp.1_Missense_Mutation_p.P2856A	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2897					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TAATGCCTCTCCTGTGATTTC	0.582													9	42					0	0	0	0	G	16261424	G	G	16261424	3	3	116	1	0	0	0	0	1	0	0	0	15104	855	30	2	8731	2	SPEN	1	16261424	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	8347951	16261424	232989197	3	20700											
UBR4	23352	broad.mit.edu	37	chr1	19451151	19451151	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccatttctgttagaagctGagtataggcctcaaacacat	13	12	7	9	0	2	2	1	1	1	1	2	2	2	2	2	1	3	3	2	1	6	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:19451151G>C	uc001bbi.2	-	65	9476	c.9472C>G	c.(9472-9474)CAG>GAG	p.Q3158E	UBR4_uc001bbk.1_Missense_Mutation_p.Q805E	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3158					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GTTAGAAGCTGAGTATAGGCC	0.428													11	58					0	0	0	0	C	19451151	C	C	19451151	3	2	116	1	0	0	0	0	1	0	0	0	16972	1299	45	2	6247	2	UBR4	1	19451151	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3189727	19451151	229799470	4	20701											
UBR4	23352	broad.mit.edu	37	chr1	19453067	19453067	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttccaatattccagcagtGatttgagcacgtgcaggcag	10	11	10	10	1	1	2	0	2	1	0	3	2	3	2	2	1	3	4	2	1	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:19453067G>C	uc001bbi.2	-	64	9315	c.9311C>G	c.(9310-9312)TCA>TGA	p.S3104*	UBR4_uc001bbk.1_Nonsense_Mutation_p.S751*	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3104					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TTCCAGCAGTGATTTGAGCAC	0.537													39	124					0	0	0	0	C	19453067	C	C	19453067	4	2	116	1	0	0	0	0	0	1	0	0	16972	1294	45	2	6412	2	UBR4	1	19453067	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1916	19453067	229797554	5	20702											
HTR6	3362	broad.mit.edu	37	chr1	19992627	19992627	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcctggaccgctacctgctCatcctctcgccgctgcgcta	5	9	9	18	4	2	0	1	0	1	0	4	1	3	1	5	1	4	4	5	1	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:19992627C>G	uc001bcl.2	+	1	848	c.381C>G	c.(379-381)CTC>CTG	p.L127L		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	127	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	GCTACCTGCTCATCCTCTCGC	0.687													8	102					0	0	0	0	G	19992627	G	G	19992627	2	3	116	1	0	0	0	0	0	0	0	1	7490	813	29	2		2	HTR6	1	19992627	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	539560	19992627	229257994	6	20703											
CLIC4	25932	broad.mit.edu	37	chr1	25153552	25153552	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaatactgctggaatggaCatctttgccaaattctctgc	11	13	7	10	0	3	0	1	0	2	0	4	2	3	2	1	2	4	1	1	2	4	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:25153552C>T	uc001bjo.2	+	4	645	c.360C>T	c.(358-360)GAC>GAT	p.D120D	CLIC4_uc001bjn.2_RNA|CLIC4_uc001bjp.1_Silent_p.D100D	NM_013943	NP_039234	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	120	GST C-terminal.				cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)		CTGGAATGGACATCTTTGCCA	0.333													16	143					0	0	0	0	T	25153552	T	T	25153552	2	4	116	1	0	0	0	0	0	0	0	1	3543	477	17	4		4	CLIC4	1	25153552	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	5160925	25153552	224097069	7	20704											
KIAA0319L	79932	broad.mit.edu	37	chr1	35917293	35917293	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctcatctttgacagtcaaGgtgaacacataggtccccac	11	10	7	13	0	3	2	2	2	2	0	5	2	4	2	2	2	1	0	2	2	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:35917293G>T	uc001byx.2	-	13	2256	c.1998C>A	c.(1996-1998)ACC>ACA	p.T666T	KIAA0319L_uc001byw.2_Silent_p.T108T|KIAA0319L_uc010ohv.1_Silent_p.T308T	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	666	PKD 4.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGACAGTCAAGGTGAACACAT	0.498											OREG0013354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	129					1.61572e-30	2.3356e-30	1	0	T	35917293	T	T	35917293	2	4	116	1	0	0	0	0	0	0	0	1	8208	987	35	4		4	KIAA0319L	1	35917293	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	10763741	35917293	213333328	8	20705											
EIF2C4	192670	broad.mit.edu	37	chr1	36291379	36291379	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggttttcatcagtctgtGagacctgccatgtggaatat	8	16	10	7	0	3	1	2	1	1	1	3	3	3	2	2	2	1	1	2	2	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:36291379G>T	uc001bzj.1	+	5	778	c.588G>T	c.(586-588)GTG>GTT	p.V196V		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	196					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATCAGTCTGTGAGACCTGCCA	0.483													42	132					1.32136e-16	1.88673e-16	1	0	T	36291379	T	T	36291379	2	4	116	1	0	0	0	0	0	0	0	1	5030	1277	45	2		2	EIF2C4	1	36291379	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	374086	36291379	212959242	9	20706											
EIF2C3	192669	broad.mit.edu	37	chr1	36474571	36474571	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttcagagaaaagtatactCttcagctgaagtacccgcac	14	10	7	10	1	3	2	2	1	1	1	3	3	3	2	1	0	3	4	1	0	6	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:36474571C>G	uc001bzp.2	+	8	1211	c.955C>G	c.(955-957)CTT>GTT	p.L319V	EIF2C3_uc001bzq.2_Missense_Mutation_p.L85V	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	319	PAZ.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAAGTATACTCTTCAGCTGAA	0.438													10	63					0	0	0	0	G	36474571	G	G	36474571	3	3	116	1	0	0	0	0	1	0	0	0	5029	913	32	2	985	2	EIF2C3	1	36474571	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	183192	36474571	212776050	10	20707											
GJA9	81025	broad.mit.edu	37	chr1	39340782	39340782	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taagtgtggaaatctcattaGaaagtacagtttcctgttca	13	14	8	6	0	2	1	2	0	1	1	4	2	3	2	1	1	1	3	1	1	5	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:39340782G>C	uc001cct.1	-	2	1270	c.989C>G	c.(988-990)TCT>TGT	p.S330C	RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399	P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	330	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			AATCTCATTAGAAAGTACAGT	0.313													21	48					0	0	0	0	C	39340782	C	C	39340782	3	2	116	1	0	0	0	0	1	0	0	0	6443	942	33	2	562	2	GJA9	1	39340782	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2866211	39340782	209909839	11	20708											
BMP8B	656	broad.mit.edu	37	chr1	40230448	40230448	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgttgggagcgtggggcccGttgacccagcaggccggcca	5	6	17	13	3	0	1	0	1	0	0	0	2	0	2	4	5	2	3	4	5	0	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:40230448G>A	uc001cdz.1	-	4	1091	c.715C>T	c.(715-717)CGG>TGG	p.R239W	BMP8B_uc001cea.1_Intron	NM_001720	NP_001711	P34820	BMP8B_HUMAN	bone morphogenetic protein 8B preproprotein	239					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity				0	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CGTGGGGCCCGTTGACCCAGC	0.657													8	103					0	0	0	0	A	40230448	A	A	40230448	3	1	116	1	0	0	0	0	1	0	0	0	1470	1144	40	1	509	1	BMP8B	1	40230448	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	889666	40230448	209020173	12	20709											
MFSD2A	84879	broad.mit.edu	37	chr1	40433512	40433512	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcatcttggtggccctcatgGagagtaacctcatcattaca	10	12	8	11	0	5	1	4	0	1	1	5	2	5	1	2	3	2	1	2	3	2	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:40433512G>A	uc001cev.2	+	11	1352	c.1171G>A	c.(1171-1173)GAG>AAG	p.E391K	MFSD2A_uc010ojb.1_Missense_Mutation_p.E339K|MFSD2A_uc001ceu.2_Missense_Mutation_p.E378K|MFSD2A_uc010ojc.1_Missense_Mutation_p.E222K|MFSD2A_uc009vvy.2_Intron|MFSD2A_uc001cex.2_Missense_Mutation_p.E42K	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	391	Helical; (Potential).				transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						GGCCCTCATGGAGAGTAACCT	0.542													11	69					0	0	0	0	A	40433512	A	A	40433512	3	1	116	1	0	0	0	0	1	0	0	0	9583	1175	41	2	1213	2	MFSD2A	1	40433512	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	203064	40433512	208817109	13	20710											
ZNF643	65243	broad.mit.edu	37	chr1	40928626	40928626	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccaaagttcatctcttattCcgcatcagagaattcatact	12	13	5	11	1	4	1	3	0	1	1	6	2	5	1	2	0	1	2	2	0	4	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:40928626C>T	uc001cfn.1	+	5	1267	c.970C>T	c.(970-972)CCG>TCG	p.P324S	ZNF643_uc001cfl.1_Missense_Mutation_p.P222S|ZNF643_uc001cfm.1_Missense_Mutation_p.P190S	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	324	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			ATCTCTTATTCCGCATCAGAG	0.403													9	48					0	0	0	0	T	40928626	T	T	40928626	3	4	116	1	0	0	0	0	1	0	0	0	18126	855	30	2	988	2	ZNF643	1	40928626	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	495114	40928626	208321995	14	20711											
TIE1	7075	broad.mit.edu	37	chr1	43778211	43778211	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccagctggatgtgcagctCtaccactgcaccctcctggg	7	9	10	15	0	1	0	0	0	1	0	2	1	2	1	4	2	6	4	4	2	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:43778211C>G	uc001ciu.2	+	12	1945	c.1866C>G	c.(1864-1866)CTC>CTG	p.L622L	TIE1_uc010okd.1_Silent_p.L622L|TIE1_uc010oke.1_Silent_p.L577L|TIE1_uc009vwq.2_Silent_p.L578L|TIE1_uc010okf.1_Silent_p.L267L|TIE1_uc010okg.1_Silent_p.L267L	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	622	Fibronectin type-III 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.L622L(1)		lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ATGTGCAGCTCTACCACTGCA	0.692													5	86					0	0	0	0	G	43778211	G	G	43778211	2	3	116	1	0	0	0	0	0	0	0	1	15959	900	32	2		2	TIE1	1	43778211	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2849585	43778211	205472410	15	20712											
ZSWIM5	57643	broad.mit.edu	37	chr1	45671764	45671764	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacgggctccgggatccgctCgaagcgctcctccacccgtt	5	7	11	18	6	0	0	0	0	0	0	5	2	4	1	5	2	1	4	5	2	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:45671764C>G	uc001cnd.2	-	1	487	c.259G>C	c.(259-261)GAG>CAG	p.E87Q		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	87							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					GGGATCCGCTCGAAGCGCTCC	0.627													11	36					0	0	0	0	G	45671764	G	G	45671764	3	3	116	1	0	0	0	0	1	0	0	0	18311	893	31	3	3354	3	ZSWIM5	1	45671764	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1893553	45671764	203578857	16	20713											
C1orf163	65260	broad.mit.edu	37	chr1	53153466	53153466	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctcgattttttagcacctCggccttggcctcatccttat	5	15	8	13	2	1	0	1	0	0	0	4	1	2	0	4	3	1	2	4	3	2	5	rs141260822		TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:53153466C>T	uc001cui.1	-	3	662	c.622G>A	c.(622-624)GAG>AAG	p.E208K		NM_023077	NP_075565	Q96BR5	SELR1_HUMAN	hypothetical protein LOC65260	208	Sel1-like 5.						binding				0						TTTAGCACCTCGGCCTTGGCC	0.532													25	76					0	0	0	0	T	53153466	T	T	53153466	3	4	116	1	0	0	0	0	1	0	0	0	2020	893	31	1	77	1	C1orf163	1	53153466	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	7481702	53153466	196097155	17	20714											
SSX2IP	117178	broad.mit.edu	37	chr1	85127939	85127939	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttttggggagaaagaagaGaaatcatttcctttttcatt	12	16	8	5	0	3	3	2	0	1	3	4	5	4	3	1	2	0	0	1	2	3	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:85127939G>A	uc001dkh.2	-	9	1144	c.869C>T	c.(868-870)TCT>TTT	p.S290F	SSX2IP_uc001dkf.2_Missense_Mutation_p.S263F|SSX2IP_uc001dkg.2_RNA|SSX2IP_uc010orz.1_Missense_Mutation_p.S263F|SSX2IP_uc001dki.2_Missense_Mutation_p.S290F|SSX2IP_uc010osa.1_Missense_Mutation_p.S263F|SSX2IP_uc001dkj.2_Missense_Mutation_p.S290F|SSX2IP_uc009wci.2_Intron|SSX2IP_uc001dkk.1_Missense_Mutation_p.S286F	NM_014021	NP_054740	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting	290	Potential.				cell adhesion	nucleus|protein complex				ovary(2)	2				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AGAAAGAAGAGAAATCATTTC	0.338													13	122					0	0	0	0	A	85127939	A	A	85127939	3	1	116	1	0	0	0	0	1	0	0	0	15270	942	33	2	1003	2	SSX2IP	1	85127939	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	31974473	85127939	164122682	18	20715											
ABCA4	24	broad.mit.edu	37	chr1	94512578	94512578	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctggccggccacagggctCaaaaatctttaccagattct	11	9	9	12	1	3	1	1	0	2	1	3	1	3	1	3	3	2	2	3	3	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:94512578C>G	uc001dqh.2	-	19	2919	c.2815G>C	c.(2815-2817)GAG>CAG	p.E939Q	ABCA4_uc010otn.1_Missense_Mutation_p.E865Q	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	939	Cytoplasmic.|ABC transporter 1.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CCACAGGGCTCAAAAATCTTT	0.507													15	236					0	0	0	0	G	94512578	G	G	94512578	3	3	116	1	0	0	0	0	1	0	0	0	34	835	29	2	4134	2	ABCA4	1	94512578	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	9384639	94512578	154738043	19	20716											
ABCD3	5825	broad.mit.edu	37	chr1	94955518	94955518	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggagaaatcattattgcaGataacattataaagtacgta	17	12	7	5	1	1	2	1	0	0	2	1	3	1	2	0	1	3	3	0	1	8	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:94955518G>C	uc001dqn.3	+	15	1411	c.1309G>C	c.(1309-1311)GAT>CAT	p.D437H	ABCD3_uc010oto.1_Missense_Mutation_p.D461H|ABCD3_uc010otp.1_Missense_Mutation_p.D364H|ABCD3_uc009wdr.2_Missense_Mutation_p.D327H|ABCD3_uc001dqo.3_Missense_Mutation_p.D125H	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	437					peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		CATTATTGCAGATAACATTAT	0.323													14	88					0	0	0	0	C	94955518	C	C	94955518	3	2	116	1	0	0	0	0	1	0	0	0	62	942	33	2	1398	2	ABCD3	1	94955518	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	442940	94955518	154295103	20	20717											
KCNC4	3749	broad.mit.edu	37	chr1	110754320	110754320	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgcctcgcctggctggccGaccccgacggcgggggccgg	2	3	17	19	7	0	0	0	0	0	0	1	2	0	0	7	6	0	1	7	6	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:110754320G>A	uc001dzh.2	+	1	256	c.199G>A	c.(199-201)GAC>AAC	p.D67N	KCNC4_uc001dzf.2_Missense_Mutation_p.D67N|KCNC4_uc009wfr.2_Missense_Mutation_p.D67N|KCNC4_uc001dzg.2_Missense_Mutation_p.D67N|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	67	Cytoplasmic (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTGGCTGGCCGACCCCGACGG	0.522													6	25					0	0	0	0	A	110754320	A	A	110754320	3	1	116	1	0	0	0	0	1	0	0	0	8056	1058	37	1	201	1	KCNC4	1	110754320	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	15798802	110754320	138496301	21	20718											
KCND3	3752	broad.mit.edu	37	chr1	112524371	112524371	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgatggccatggtgagggaGaagagaagaaagcccagttc	14	6	15	6	0	0	5	0	2	0	3	1	7	0	5	2	3	1	1	2	3	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:112524371G>A	uc001ebu.1	-	2	1458	c.978C>T	c.(976-978)TTC>TTT	p.F326F	KCND3_uc001ebv.1_Silent_p.F326F	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	326	Helical; Name=Segment S5; (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		TGGTGAGGGAGAAGAGAAGAA	0.552													9	47					0	0	0	0	A	112524371	A	A	112524371	2	1	116	1	0	0	0	0	0	0	0	1	8059	933	33	2		2	KCND3	1	112524371	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1770051	112524371	136726250	22	20719											
AP4B1	10717	broad.mit.edu	37	chr1	114442908	114442908	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacctgggctactgctcttGaggaaactatccaacagatt	12	10	8	11	0	1	2	0	1	1	1	2	3	2	3	2	2	4	2	2	2	4	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:114442908G>C	uc001eeb.2	-	5	875	c.732C>G	c.(730-732)CTC>CTG	p.L244L	uc001edv.1_RNA|AP4B1_uc001eec.2_Silent_p.L76L|AP4B1_uc001eed.2_Silent_p.L244L|AP4B1_uc010owp.1_Silent_p.L145L|AP4B1_uc001eea.1_Silent_p.L38L|AP4B1_uc010owq.1_Silent_p.L151L	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	244					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTGCTCTTGAGGAAACTAT	0.473													5	56					0	0	0	0	C	114442908	C	C	114442908	2	2	116	1	0	0	0	0	0	0	0	1	751	1277	45	2		2	AP4B1	1	114442908	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1918537	114442908	134807713	23	20720											
FAM46C	54855	broad.mit.edu	37	chr1	118166279	118166279	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccacagaccaggaagaaatCaaaactctagagcgctacat	17	5	7	12	1	2	3	1	0	1	3	2	4	2	4	2	1	3	1	2	1	6	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:118166279C>G	uc001ehe.2	+	2	988	c.789C>G	c.(787-789)ATC>ATG	p.I263M		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	263											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		AGGAAGAAATCAAAACTCTAG	0.507										Multiple Myeloma(3;1.13e-06)			14	38					0	0	0	0	G	118166279	G	G	118166279	3	3	116	1	0	0	0	0	1	0	0	0	5599	816	29	2	791	2	FAM46C	1	118166279	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3723371	118166279	131084342	24	20721											
PDE4DIP	9659	broad.mit.edu	37	chr1	144952223	144952223	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccctctgggccagggcctCagtgtattggtcgggcttga	4	11	15	11	1	2	1	1	1	1	0	4	1	3	1	3	4	0	2	3	4	1	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:144952223C>T	uc001elw.3	-	4	787	c.496G>A	c.(496-498)GAG>AAG	p.E166K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.E232K|PDE4DIP_uc001emc.1_Missense_Mutation_p.E166K|PDE4DIP_uc001emd.1_Missense_Mutation_p.E166K|PDE4DIP_uc001emg.1_Missense_Mutation_p.E166K|PDE4DIP_uc001emh.2_Missense_Mutation_p.E303K	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	166	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCCAGGGCCTCAGTGTATTGG	0.522			T	PDGFRB	MPD								15	157					0	0	0	0	T	144952223	T	T	144952223	3	4	116	1	0	0	0	0	1	0	0	0	11697	835	29	2	7851	2	PDE4DIP	1	144952223	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	26785944	144952223	104298398	25	20722											
RPRD2	23248	broad.mit.edu	37	chr1	150437148	150437148	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggtggagatcaccccagaGagcattctgtctgcactttc	10	10	10	11	0	3	2	1	0	2	2	4	4	3	2	2	2	2	2	2	2	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:150437148G>C	uc009wlr.2	+	10	1758	c.1557G>C	c.(1555-1557)GAG>GAC	p.E519D	RPRD2_uc010pcc.1_Missense_Mutation_p.E493D|RPRD2_uc001eup.3_Missense_Mutation_p.E493D	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	519	Ser-rich.						protein binding			ovary(1)	1						TCACCCCAGAGAGCATTCTGT	0.517											OREG0013786	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	19					0	0	0	0	C	150437148	C	C	150437148	3	2	116	1	0	0	0	0	1	0	0	0	13682	933	33	2	1595	2	RPRD2	1	150437148	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5484925	150437148	98813473	26	20723											
GOLPH3L	55204	broad.mit.edu	37	chr1	150636160	150636160	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgggggttccagatagattCgaccccgcatggccagctct	7	9	12	13	3	1	2	0	0	1	2	4	3	2	2	4	3	1	3	4	3	1	3	rs150623963		TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:150636160C>T	uc001evj.2	-	3	480	c.263G>A	c.(262-264)CGA>CAA	p.R88Q	GOLPH3L_uc010pci.1_Intron	NM_018178	NP_060648	Q9H4A5	GLP3L_HUMAN	Golgi phosphoprotein 3-like	88						Golgi cisterna membrane				ovary(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			CAGATAGATTCGACCCCGCAT	0.502													23	61					0	0	0	0	T	150636160	T	T	150636160	3	4	116	1	0	0	0	0	1	0	0	0	6606	884	31	1	606	1	GOLPH3L	1	150636160	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	199012	150636160	98614461	27	20724											
FLG	2312	broad.mit.edu	37	chr1	152277823	152277823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaagcttcatggtgacgtGacactgagtgcctggagctg	8	10	15	8	1	1	3	1	3	0	0	1	5	1	5	1	3	3	2	1	3	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:152277823G>A	uc001ezu.1	-	3	9575	c.9539C>T	c.(9538-9540)TCA>TTA	p.S3180L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3180	Filaggrin 19.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGTGACGTGACACTGAGTG	0.562									Ichthyosis				100	139					0	0	0	0	A	152277823	A	A	152277823	3	1	116	1	0	0	0	0	1	0	0	0	5954	1294	45	2	2650	2	FLG	1	152277823	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1641663	152277823	96972798	28	20725											
FLG2	388698	broad.mit.edu	37	chr1	152327869	152327870	+	Missense_Mutation	DNP	CC	AT	AT																															tggattgacttgagcctgacCcatgttgtccaaagccagat																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:152327869_152327870CC>AT	uc001ezw.3	-	3	2465_2466	c.2392_2393GG>AT	c.(2392-2394)GGG>ATG	p.G798M	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	798	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGCCTGACCCATGTTGTCCA	0.52													43	409					0	0	0	0	AT	152327870	AT	AT	152327869	3	1	116	1	0	0	0	0	1	0	0	0	5955	623	22	4	4786	4	FLG2	1	152327869	Missense_Mutation	DNP	CC	TCGA-CR-5248-01A-01D-2012-08	50046	152327869	96922752	29	20726											
CLK2	1196	broad.mit.edu	37	chr1	155238104	155238104	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgcgatggtcaacacattgTacaactcggccgaaggtccc	10	8	10	13	3	1	0	1	0	0	0	3	2	2	0	2	3	4	1	2	3	4	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:155238104T>C	uc001fjy.2	-	5	824	c.534A>G	c.(532-534)GTA>GTG	p.V178V	RAG1AP1_uc010pey.1_Intron|CLK2_uc001fjw.2_Silent_p.V177V|CLK2_uc001fjx.2_5'UTR|CLK2_uc009wqm.2_Silent_p.V178V	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	178	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CAACACATTGTACAACTCGGC	0.502								Other_conserved_DNA_damage_response_genes					15	51					0	0	0	0	C	155238104	C	C	155238104	2	2	116	1	0	0	0	0	0	0	0	1	3552	1625	57	5		5	CLK2	1	155238104	Silent	SNP	T	TCGA-CR-5248-01A-01D-2012-08	2910235	155238104	94012517	30	20727											
RUSC1	23623	broad.mit.edu	37	chr1	155292421	155292421	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacacaagaataactgattCtggctcgaaaacagatgcag	17	7	8	9	1	1	3	0	1	1	2	2	4	1	3	0	1	4	2	0	1	6	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:155292421C>G	uc001fkj.2	+	2	1086	c.857C>G	c.(856-858)TCT>TGT	p.S286C	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_5'Flank|C1orf104_uc001fki.2_Intron|RUSC1_uc001fkk.2_Missense_Mutation_p.S286C|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank|RUSC1_uc001fkn.2_5'Flank|RUSC1_uc001fko.2_5'Flank|RUSC1_uc001fkr.2_5'Flank|RUSC1_uc001fks.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	286						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			ATAACTGATTCTGGCTCGAAA	0.478													36	120					0	0	0	0	G	155292421	G	G	155292421	3	3	116	1	0	0	0	0	1	0	0	0	13815	913	32	2	859	2	RUSC1	1	155292421	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	54317	155292421	93958200	31	20728											
DAP3	7818	broad.mit.edu	37	chr1	155699156	155699156	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaagagaagataaaagccCggtaggaaaactgggtgtct	17	6	13	5	1	1	2	0	0	1	2	1	5	1	3	1	3	2	1	1	3	8	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:155699156C>G	uc001flq.2	+	9	1011	c.842C>G	c.(841-843)CCG>CGG	p.P281R	DAP3_uc001flr.2_Missense_Mutation_p.P281R|DAP3_uc001fls.2_Missense_Mutation_p.P281R|DAP3_uc010pgl.1_Missense_Mutation_p.P240R|DAP3_uc001flt.2_Missense_Mutation_p.P247R|DAP3_uc001flu.2_Missense_Mutation_p.P254R|DAP3_uc010pgm.1_Missense_Mutation_p.P247R	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	281					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GATAAAAGCCCGGTAGGAAAA	0.438													18	59					0	0	0	0	G	155699156	G	G	155699156	3	3	116	1	0	0	0	0	1	0	0	0	4251	666	23	3	872	3	DAP3	1	155699156	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	406735	155699156	93551465	32	20729											
IGSF9	57549	broad.mit.edu	37	chr1	159912846	159912846	+	Frame_Shift_Del	DEL	G	-	-																															cagccactcgatgacatgcaGggggggccggccggccgggg																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:159912846delG	uc001fur.2	-	3	352	c.154delC	c.(154-156)CTGfs	p.L52fs	IGSF9_uc001fuq.2_Frame_Shift_Del_p.L52fs	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	52	Ig-like 1.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			ATGACATGCAgggggggccgg	0.522													---	---	---								-	159912846	-	-	159912846	7	5	116	1	0	1	0	1	0	0	0	0	7644	991	35	0	3461	0	IGSF9	1	159912846	Frame_Shift_Del	DEL	G	TCGA-CR-5248-01A-01D-2012-08	4213690	159912846	89337775	33	20730											
HSPA6	3310	broad.mit.edu	37	chr1	161494658	161494658	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aacccccacaacaccgtgttCgatgccaagcggctgatcgg	10	6	10	15	4	0	1	0	1	0	0	2	2	0	1	4	2	4	2	4	2	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:161494658C>G	uc001gap.2	+	2	870	c.210C>G	c.(208-210)TTC>TTG	p.F70L	HSPA6_uc001gaq.2_Missense_Mutation_p.F70L	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	70					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			ACACCGTGTTCGATGCCAAGC	0.687													8	28					0	0	0	0	G	161494658	G	G	161494658	3	3	116	1	0	0	0	0	1	0	0	0	7454	883	31	3	212	3	HSPA6	1	161494658	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1581812	161494658	87755963	34	20731											
POGK	57645	broad.mit.edu	37	chr1	166819358	166819358	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcgtggtctacaagccactGaatgacagtgtgcgggccca	9	8	13	11	2	1	2	0	2	1	0	2	2	1	2	2	2	3	0	2	2	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:166819358G>C	uc001gdt.1	+	5	1662	c.1542G>C	c.(1540-1542)CTG>CTC	p.L514L	POGK_uc010ple.1_Silent_p.L429L|POGK_uc010plf.1_Silent_p.L396L	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	514	DDE.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						acaagccactgaatgacagtg	0.05													4	12					0	0	0	0	C	166819358	C	C	166819358	2	2	116	1	0	0	0	0	0	0	0	1	12240	1277	45	2		2	POGK	1	166819358	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5324700	166819358	82431263	35	20732											
TNN	63923	broad.mit.edu	37	chr1	175046766	175046766	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcagtgacgatggggcttCgctcttggccctgggggagg	4	9	17	11	2	2	1	1	1	1	0	3	3	2	2	2	6	0	2	2	6	0	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:175046766C>T	uc001gkl.1	+	2	325	c.212C>T	c.(211-213)TCG>TTG	p.S71L	TNN_uc010pmx.1_Missense_Mutation_p.S71L	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	71					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GATGGGGCTTCGCTCTTGGCC	0.587													10	33					0	0	0	0	T	175046766	T	T	175046766	3	4	116	1	0	0	0	0	1	0	0	0	16389	893	31	1	214	1	TNN	1	175046766	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	8227408	175046766	74203855	36	20733											
GLT25D2	23127	broad.mit.edu	37	chr1	184006371	184006371	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccgggaaaaccaccggctCctctccgtcgtcctccgagt	6	8	9	18	5	1	0	0	0	1	0	7	2	5	1	7	2	1	1	7	2	2	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:184006371C>T	uc001gqr.2	-	1	493	c.121G>A	c.(121-123)GAG>AAG	p.E41K	GLT25D2_uc010poj.1_Missense_Mutation_p.E41K|GLT25D2_uc001gqs.2_Intron	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	41					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						ACCACCGGCTCCTCTCCGTCG	0.721													4	14					0	0	0	0	T	184006371	T	T	184006371	3	4	116	1	0	0	0	0	1	0	0	0	6504	864	30	2	1807	2	GLT25D2	1	184006371	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	8959605	184006371	65244250	37	20734											
KCNT2	343450	broad.mit.edu	37	chr1	196309572	196309572	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcttggtttttaaatgctGaattctcttctttggtaata	8	20	8	5	0	3	1	0	1	3	0	4	1	3	1	0	3	1	3	0	3	5	9			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:196309572G>T	uc001gtd.1	-	16	1742	c.1682C>A	c.(1681-1683)TCA>TAA	p.S561*	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Nonsense_Mutation_p.S511*|KCNT2_uc001gtf.1_Nonsense_Mutation_p.S561*|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Nonsense_Mutation_p.S561*|KCNT2_uc001gth.1_Nonsense_Mutation_p.S82*	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	561	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TTTAAATGCTGAATTCTCTTC	0.358													8	37					3.09899e-07	4.2785e-07	1	0	T	196309572	T	T	196309572	4	4	116	1	0	0	0	0	0	1	0	0	8131	1294	45	2	1777	2	KCNT2	1	196309572	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	12303201	196309572	52941049	38	20735											
LGR6	59352	broad.mit.edu	37	chr1	202245595	202245595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgaccctggccctcaaccGcatcagccacatccccgact	9	6	6	20	2	2	1	2	1	0	0	3	2	3	1	6	1	2	1	6	1	1	0	rs142083498		TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:202245595G>A	uc001gxu.2	+	5	590	c.590G>A	c.(589-591)CGC>CAC	p.R197H	LGR6_uc001gxv.2_Missense_Mutation_p.R145H|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Intron|LGR6_uc009xac.1_RNA	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	197	LRR 5.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						GCCCTCAACCGCATCAGCCAC	0.637													9	33					0	0	0	0	A	202245595	A	A	202245595	3	1	116	1	0	0	0	0	1	0	0	0	8799	1087	38	1	755	1	LGR6	1	202245595	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5936023	202245595	47005026	39	20736											
G0S2	50486	broad.mit.edu	37	chr1	209849324	209849324	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggccgggccctgtccaacCggcagcacgcctcctaggaa	7	4	13	17	4	0	0	0	0	0	0	2	1	2	1	6	4	2	2	6	4	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:209849324C>T	uc001hhi.3	+	2	552	c.295C>T	c.(295-297)CGG>TGG	p.R99W		NM_015714	NP_056529	P27469	G0S2_HUMAN	G0/G1switch 2	99					cell cycle						0				OV - Ovarian serous cystadenocarcinoma(81;0.041)		CCTGTCCAACCGGCAGCACGC	0.662													9	30					0	0	0	0	T	209849324	T	T	209849324	3	4	116	1	0	0	0	0	1	0	0	0	6173	643	23	1	297	1	G0S2	1	209849324	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	7603729	209849324	39401297	40	20737											
OR2L8	391190	broad.mit.edu	37	chr1	248112521	248112521	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcatctatggcctatgatcGttacattgctatttgctttc	7	17	8	9	1	1	1	0	1	1	0	3	1	1	1	1	2	3	4	1	2	4	7	rs148005952	byFrequency	TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr1:248112521G>A	uc001idt.1	+	1	362	c.362G>A	c.(361-363)CGT>CAT	p.R121H	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GCCTATGATCGTTACATTGCT	0.443													38	153					0	0	0	0	A	248112521	A	A	248112521	3	1	116	1	0	0	0	0	1	0	0	0	11063	1145	40	1	364	1	OR2L8	1	248112521	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	38263197	248112521	1138100	41	20738											
ATP6V1C2	245973	broad.mit.edu	37	chr2	10917766	10917766	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caccttcccggaccacaaggTtaaggtaaccccgctaggta	11	7	9	14	2	0	0	0	0	0	0	1	1	1	1	5	4	1	4	5	4	5	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:10917766T>C	uc002ras.2	+	11	990	c.881T>C	c.(880-882)GTT>GCT	p.V294A	ATP6V1C2_uc002rat.2_Intron	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	vacuolar H+ ATPase C2 isoform a	294					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		GACCACAAGGTTAAGGTAACC	0.512													17	55					0	0	0	0	C	10917766	C	C	10917766	3	2	116	1	0	0	0	0	1	0	0	0	1183	1725	60	5	919	5	ATP6V1C2	2	10917766	Missense_Mutation	SNP	T	TCGA-CR-5248-01A-01D-2012-08		10917766	232281607	42	20739											
APOB	338	broad.mit.edu	37	chr2	21231537	21231537	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaattctggtatgtgaaggtCaggaacttgaaaatcattaa	15	12	10	4	0	3	2	2	2	1	0	3	4	3	3	0	3	1	1	0	3	7	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:21231537C>G	uc002red.2	-	26	8331	c.8203G>C	c.(8203-8205)GAC>CAC	p.D2735H		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2735				Missing (in Ref. 15; AAA51758).	cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGTGAAGGTCAGGAACTTGA	0.418													22	116					0	0	0	0	G	21231537	G	G	21231537	3	3	116	1	0	0	0	0	1	0	0	0	785	826	29	2	5504	2	APOB	2	21231537	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	10313771	21231537	221967836	43	20740											
GTF3C2	2976	broad.mit.edu	37	chr2	27559195	27559195	+	Frame_Shift_Del	DEL	C	-	-																															cacatattgcgaggctcctgCcccctctggcactgggcacc																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:27559195delC	uc002rjv.1	-	9	1588	c.1225delG	c.(1225-1227)GCAfs	p.A409fs	GTF3C2_uc010eyy.1_5'Flank|GTF3C2_uc002rju.1_Frame_Shift_Del_p.A420fs|GTF3C2_uc002rjw.1_Frame_Shift_Del_p.A409fs|GTF3C2_uc010eyz.1_Frame_Shift_Del_p.A409fs|uc002rjy.1_RNA	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	409						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGGCTCCTGCCCCCTCTGGC	0.592													---	---	---								-	27559195	-	-	27559195	7	5	116	1	0	1	0	1	0	0	0	0	6912	739	26	0	1558	0	GTF3C2	2	27559195	Frame_Shift_Del	DEL	C	TCGA-CR-5248-01A-01D-2012-08	6327658	27559195	215640178	44	20741											
THUMPD2	80745	broad.mit.edu	37	chr2	39997221	39997221	+	Missense_Mutation	SNP	C	T	T																															attcaaccaacttcctggatCttcatttataagtctttgca																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:39997221C>T	uc002rru.2	-	3	338	c.301G>A	c.(301-303)GAT>AAT	p.D101N	THUMPD2_uc002rrv.2_RNA|THUMPD2_uc010ynt.1_Missense_Mutation_p.D8N|THUMPD2_uc010ynu.1_Missense_Mutation_p.D101N	NM_025264	NP_079540	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	101							methyltransferase activity			skin(1)	1		all_hematologic(82;0.248)				CTTCCTGGATCTTCATTTATA	0.289													5	36					0	0	0	0	T	39997221	T	T	39997221	3	4	116	1	0	0	0	0	1	0	0	0	15949	913	32	2	1242	2	THUMPD2	2	39997221	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	12438026	39997221	203202152	45	20742	41	2									
THUMPD2	80745	broad.mit.edu	37	chr2	39997224	39997224	+	Missense_Mutation	SNP	C	T	T																															caaccaacttcctggatcttCatttataagtctttgcattt																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:39997224C>T	uc002rru.2	-	3	335	c.298G>A	c.(298-300)GAA>AAA	p.E100K	THUMPD2_uc002rrv.2_RNA|THUMPD2_uc010ynt.1_Missense_Mutation_p.E7K|THUMPD2_uc010ynu.1_Missense_Mutation_p.E100K	NM_025264	NP_079540	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	100							methyltransferase activity			skin(1)	1		all_hematologic(82;0.248)				CCTGGATCTTCATTTATAAGT	0.299													5	35					0	0	0	0	T	39997224	T	T	39997224	3	4	116	1	0	0	0	0	1	0	0	0	15949	835	29	2	1245	2	THUMPD2	2	39997224	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3	39997224	203202149	46	20743	41	2									
ZFP36L2	678	broad.mit.edu	37	chr2	43451806	43451806	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acggcggcaaagttgtgggtCtggatggcgagcggcgtgat	7	8	19	7	5	1	1	0	1	1	0	1	3	1	2	0	6	1	2	0	6	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:43451806C>T	uc002rsv.3	-	2	1428	c.1137G>A	c.(1135-1137)CAG>CAA	p.Q379Q	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	379					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				AGTTGTGGGTCTGGATGGCGA	0.393													6	14					0	0	0	0	T	43451806	T	T	43451806	2	4	116	1	0	0	0	0	0	0	0	1	17714	912	32	2		2	ZFP36L2	2	43451806	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3454582	43451806	199747567	47	20744											
SOCS5	9655	broad.mit.edu	37	chr2	46986960	46986960	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatccctgcatgcccgaattGagcagtggaatcacaacttt	11	10	9	11	1	1	1	1	1	0	0	2	4	2	2	2	1	4	2	2	1	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:46986960G>C	uc002rvf.2	+	2	1455	c.1291G>C	c.(1291-1293)GAG>CAG	p.E431Q	SOCS5_uc010yoe.1_Missense_Mutation_p.E400Q|SOCS5_uc002rvg.2_Missense_Mutation_p.E431Q	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	431	SH2.				cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TGCCCGAATTGAGCAGTGGAA	0.493													32	87					0	0	0	0	C	46986960	C	C	46986960	3	2	116	1	0	0	0	0	1	0	0	0	14981	1291	45	2	1293	2	SOCS5	2	46986960	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3535154	46986960	196212413	48	20745											
KLRAQ1	129285	broad.mit.edu	37	chr2	48687279	48687279	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagccaaggaatgtcgacttCgaacggaagaatggtatgtg	14	8	13	6	3	0	1	0	0	0	1	2	5	0	3	1	3	2	1	1	3	7	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:48687279C>T	uc002rwm.2	+	6	771	c.586C>T	c.(586-588)CGA>TGA	p.R196*	KLRAQ1_uc002rwi.1_Nonsense_Mutation_p.R196*|KLRAQ1_uc002rwj.2_Nonsense_Mutation_p.R196*|KLRAQ1_uc002rwl.2_Nonsense_Mutation_p.R150*|KLRAQ1_uc002rwk.2_Nonsense_Mutation_p.R196*|KLRAQ1_uc010yok.1_Nonsense_Mutation_p.R196*	NM_001135629	NP_001129101	Q6ZMI0	KLRAQ_HUMAN	KLRAQ motif containing 1 isoform 1	196	Potential.									ovary(1)	1						ATGTCGACTTCGAACGGAAGA	0.403													11	21					0	0	0	0	T	48687279	T	T	48687279	4	4	116	1	0	0	0	0	0	1	0	0	8452	876	31	1	608	1	KLRAQ1	2	48687279	Nonsense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1700319	48687279	194512094	49	20746											
NRXN1	9378	broad.mit.edu	37	chr2	50765639	50765639	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catagttgagcagagcagtcCacacctcggtggggaagaca	12	6	13	10	1	0	3	0	1	0	2	2	4	1	4	2	3	2	3	2	3	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:50765639C>A	uc010fbq.2	-	10	3492	c.2015G>T	c.(2014-2016)TGG>TTG	p.W672L	NRXN1_uc002rxb.3_Missense_Mutation_p.W304L|NRXN1_uc002rxe.3_Missense_Mutation_p.W632L|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CAGAGCAGTCCACACCTCGGT	0.517													15	186					1.05317e-09	1.4679e-09	1	0	A	50765639	A	A	50765639	3	1	116	1	0	0	0	0	1	0	0	0	10719	595	21	4	2947	4	NRXN1	2	50765639	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2078360	50765639	192433734	50	20747											
SMEK2	57223	broad.mit.edu	37	chr2	55792169	55792169	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatgggcagtaagagacttGatatcttcctgtataagcac	13	12	9	7	0	1	2	0	1	1	1	2	3	2	2	1	1	1	4	1	1	5	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:55792169G>C	uc002rzc.2	-	14	2319	c.1944C>G	c.(1942-1944)ATC>ATG	p.I648M	SMEK2_uc002rzb.2_Missense_Mutation_p.I563M|SMEK2_uc002rzd.2_Missense_Mutation_p.I616M|SMEK2_uc002ryz.2_Missense_Mutation_p.I82M|SMEK2_uc002rza.2_Missense_Mutation_p.I439M	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	648						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TAAGAGACTTGATATCTTCCT	0.279													2	9					0	0	0	0	C	55792169	C	C	55792169	3	2	116	1	0	0	0	0	1	0	0	0	14858	1280	45	2	621	2	SMEK2	2	55792169	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5026530	55792169	187407204	51	20748											
SMEK2	57223	broad.mit.edu	37	chr2	55806911	55806911	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atttagaaattcacttttttCggttttctgaaacatagaat	13	18	5	5	1	2	3	1	1	1	2	3	3	2	3	0	1	1	1	0	1	5	9			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:55806911C>T	uc002rzc.2	-	9	1747	c.1372G>A	c.(1372-1374)GAA>AAA	p.E458K	SMEK2_uc002rzb.2_Missense_Mutation_p.E458K|SMEK2_uc002rzd.2_Missense_Mutation_p.E458K|SMEK2_uc002rza.2_Missense_Mutation_p.E334K	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	458						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TCACTTTTTTCGGTTTTCTGA	0.308													10	25					0	0	0	0	T	55806911	T	T	55806911	3	4	116	1	0	0	0	0	1	0	0	0	14858	893	31	1	1213	1	SMEK2	2	55806911	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	14742	55806911	187392462	52	20749											
APLF	200558	broad.mit.edu	37	chr2	68805097	68805097	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaggaaaggaagatgaagaGaaggaagatgtggaagagct	18	4	16	3	0	0	5	0	1	0	4	0	10	0	9	1	4	1	1	1	4	6	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:68805097G>C	uc002sep.2	+	10	1652	c.1479G>C	c.(1477-1479)GAG>GAC	p.E493D	APLF_uc002seq.1_RNA|APLF_uc002ser.1_Missense_Mutation_p.E224D	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	493	Potential.				double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						AAGATGAAGAGAAGGAAGATG	0.373													9	36					0	0	0	0	C	68805097	C	C	68805097	3	2	116	1	0	0	0	0	1	0	0	0	776	933	33	2	1517	2	APLF	2	68805097	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	12998186	68805097	174394276	53	20750											
ANKRD53	79998	broad.mit.edu	37	chr2	71211740	71211740	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtgccctctgttgttgcaGaaagagcacaaaattctcag	11	12	9	9	0	2	2	1	0	2	2	3	2	2	2	1	0	3	4	1	0	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:71211740G>C	uc002shl.3	+	6	1105	c.904_splice	c.e6-1	p.K302_splice	ANKRD53_uc002shk.3_Splice_Site_p.*344_splice|ANKRD53_uc002shm.3_Splice_Site_p.*255_splice	NM_001115116	NP_001108588	Q8N9V6	ANR53_HUMAN	ankyrin repeat domain 53 isoform a												0						TGTTGTTGCAGAAAGAGCACA	0.547											OREG0014687	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	99					0	0	0	0	C	71211740	C	C	71211740	5	2	116	1	0	0	0	0	0	0	1	0	679	956	33	2	1056	2	ANKRD53	2	71211740	Splice_Site	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2406643	71211740	171987633	54	20751											
MPHOSPH10	10199	broad.mit.edu	37	chr2	71360440	71360440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaaagccccgttttcagtGatgaggattctgaccttgac	10	11	11	9	1	2	4	1	4	1	0	2	6	2	6	3	2	1	1	3	2	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:71360440G>A	uc002sht.1	+	2	854	c.502G>A	c.(502-504)GAT>AAT	p.D168N	MPHOSPH10_uc010feb.1_Missense_Mutation_p.D168N	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	168					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						CGTTTTCAGTGATGAGGATTC	0.443													7	70					0	0	0	0	A	71360440	A	A	71360440	3	1	116	1	0	0	0	0	1	0	0	0	9778	1290	45	2	508	2	MPHOSPH10	2	71360440	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	148700	71360440	171838933	55	20752											
AFF3	3899	broad.mit.edu	37	chr2	100625344	100625344	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgttgagtttcttgatttCttctttctcgttctttcctc	2	23	5	11	1	5	2	0	2	5	0	8	2	6	2	2	0	0	3	2	0	0	8			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:100625344C>T	uc002tag.2	-	4	340	c.104G>A	c.(103-105)AGA>AAA	p.R35K	AFF3_uc002taf.2_Missense_Mutation_p.R60K|AFF3_uc010fiq.1_Missense_Mutation_p.R35K|AFF3_uc010yvr.1_Missense_Mutation_p.R189K|AFF3_uc002tah.1_Missense_Mutation_p.R60K|AFF3_uc010fir.1_Missense_Mutation_p.R112K|AFF3_uc002tai.2_5'Flank	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	35					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TTCTTGATTTCTTCTTTCTCG	0.393													4	22					0	0	0	0	T	100625344	T	T	100625344	3	4	116	1	0	0	0	0	1	0	0	0	358	913	32	2	3660	2	AFF3	2	100625344	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	29264904	100625344	142574029	56	20753											
POTEF	728378	broad.mit.edu	37	chr2	130877784	130877784	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcaggggaagcagtggcagCaccacttgcccatcttgttc	9	8	12	12	0	1	0	0	0	1	0	2	1	1	1	2	3	4	5	2	3	1	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:130877784C>T	uc010fmh.2	-	3	705	c.305G>A	c.(304-306)TGC>TAC	p.C102Y		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	102						cell cortex	ATP binding			skin(3)|ovary(2)	5						GCAGTGGCAGCACCACTTGCC	0.607													36	258					0	0	0	0	T	130877784	T	T	130877784	3	4	116	1	0	0	0	0	1	0	0	0	12320	710	25	4	2982	4	POTEF	2	130877784	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	30252440	130877784	112321589	57	20754											
LRP1B	53353	broad.mit.edu	37	chr2	142004806	142004806	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataacttaccaattttagccTtgcaagatctgttgtctggc	10	15	7	9	0	2	1	0	0	2	1	2	1	2	1	2	1	4	2	2	1	5	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:142004806T>C	uc002tvj.1	-	5	1553	c.581A>G	c.(580-582)AAG>AGG	p.K194R	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	194	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATTTTAGCCTTGCAAGATCT	0.383										TSP Lung(27;0.18)			7	50					0	0	0	0	C	142004806	C	C	142004806	3	2	116	1	0	0	0	0	1	0	0	0	9005	1609	56	5	13566	5	LRP1B	2	142004806	Missense_Mutation	SNP	T	TCGA-CR-5248-01A-01D-2012-08	11127022	142004806	101194567	58	20755											
WDSUB1	151525	broad.mit.edu	37	chr2	160104982	160104982	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttaaccttggtcctgagctCttcaattttcctcagcactt	7	17	5	12	0	3	1	2	1	1	0	5	1	5	1	3	1	3	2	3	1	2	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:160104982C>T	uc002uaj.3	-	10	1323	c.1174G>A	c.(1174-1176)GAG>AAG	p.E392K	WDSUB1_uc002uak.3_Missense_Mutation_p.E392K|WDSUB1_uc002ual.3_Missense_Mutation_p.E392K|WDSUB1_uc002uam.3_Intron|WDSUB1_uc010foo.2_Missense_Mutation_p.E300K	NM_152528	NP_689741	Q8N9V3	WSDU1_HUMAN	WD repeat, sterile alpha motif and U-box domain	392	SAM.					ubiquitin ligase complex	ubiquitin-protein ligase activity				0						GTCCTGAGCTCTTCAATTTTC	0.388													7	53					0	0	0	0	T	160104982	T	T	160104982	3	4	116	1	0	0	0	0	1	0	0	0	17409	922	32	2	264	2	WDSUB1	2	160104982	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	18100176	160104982	83094391	59	20756											
KCNH7	90134	broad.mit.edu	37	chr2	163253401	163253401	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggctcttacatctgcattaGactttccaggtttggcataa	9	14	9	9	0	2	1	0	0	2	1	3	1	3	1	1	3	2	4	1	3	3	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:163253401G>C	uc002uch.1	-	11	2674	c.2462C>G	c.(2461-2463)TCT>TGT	p.S821C		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	821	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	ATCTGCATTAGACTTTCCAGG	0.373													15	31					0	0	0	0	C	163253401	C	C	163253401	3	2	116	1	0	0	0	0	1	0	0	0	8076	942	33	2	1152	2	KCNH7	2	163253401	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3148419	163253401	79945972	60	20757											
SCN3A	6328	broad.mit.edu	37	chr2	165986604	165986604	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagtcgttcatgtgccacCgtgggagcgtacagtcatca	10	9	12	10	3	3	1	3	0	0	1	4	2	3	2	2	1	3	2	2	1	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:165986604C>T	uc002ucx.2	-	17	3260	c.2768G>A	c.(2767-2769)CGG>CAG	p.R923Q	SCN3A_uc002ucy.2_Missense_Mutation_p.R874Q|SCN3A_uc002ucz.2_Missense_Mutation_p.R874Q|SCN3A_uc002uda.1_Missense_Mutation_p.R743Q|SCN3A_uc002udb.1_Missense_Mutation_p.R743Q	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	923						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CATGTGCCACCGTGGGAGCGT	0.512													49	179					0	0	0	0	T	165986604	T	T	165986604	3	4	116	1	0	0	0	0	1	0	0	0	13983	652	23	1	3282	1	SCN3A	2	165986604	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2733203	165986604	77212769	61	20758											
HOXD8	3234	broad.mit.edu	37	chr2	176996323	176996323	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctggaggaagacagagccGaaggcctgacaaattaactt	15	6	12	8	1	0	3	0	1	0	2	0	6	0	5	2	3	3	1	2	3	4	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:176996323G>A	uc002uko.2	+	2	1474	c.856G>A	c.(856-858)GAA>AAA	p.E286K	uc002ukm.1_5'Flank|HOXD8_uc002ukn.2_Missense_Mutation_p.E102K|HOXD8_uc002ukp.2_Missense_Mutation_p.E285K	NM_019558	NP_062458	P13378	HXD8_HUMAN	homeobox D8	286					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		AGACAGAGCCGAAGGCCTGAC	0.423													12	29					0	0	0	0	A	176996323	A	A	176996323	3	1	116	1	0	0	0	0	1	0	0	0	7364	1059	37	1	862	1	HOXD8	2	176996323	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	11009719	176996323	66203050	62	20759											
TTN	7273	broad.mit.edu	37	chr2	179403892	179403892	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgactctagaaccaccatCatctttgggccgggaccagg	9	9	11	12	1	3	2	1	1	2	1	3	3	3	3	4	3	1	0	4	3	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:179403892C>T	uc010zfg.1	-	302	91290	c.91066G>A	c.(91066-91068)GAT>AAT	p.D30356N	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D24051N|TTN_uc010zfi.1_Missense_Mutation_p.D23984N|TTN_uc010zfj.1_Missense_Mutation_p.D23859N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31283							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAACCACCATCATCTTTGGGC	0.468													16	60					0	0	0	0	T	179403892	T	T	179403892	3	4	116	1	0	0	0	0	1	0	0	0	16803	826	29	2	9249	2	TTN	2	179403892	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2407569	179403892	63795481	63	20760											
TTN	7273	broad.mit.edu	37	chr2	179554565	179554565	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgggggagcttcctttttCtttgcaacaggaacgggaat	8	12	13	8	1	1	0	0	0	1	0	2	3	2	3	1	4	4	3	1	4	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:179554565C>G	uc010zfg.1	-	119	28313	c.28089G>C	c.(28087-28089)AAG>AAC	p.K9363N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K6024N|TTN_uc010fre.1_Missense_Mutation_p.K474N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10290							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCCTTTTTCTTTGCAACAG	0.378													10	188					0	0	0	0	G	179554565	G	G	179554565	3	3	116	1	0	0	0	0	1	0	0	0	16803	912	32	2	72672	2	TTN	2	179554565	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	150673	179554565	63644808	64	20761											
TTN	7273	broad.mit.edu	37	chr2	179612368	179612368	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctggtctctggtgtctttaGtttcaggaacctcacgcttt	5	16	9	11	1	4	0	2	0	2	0	5	1	4	1	2	3	1	2	2	3	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:179612368G>C	uc002unb.2	-	46	14983	c.14759C>G	c.(14758-14760)ACT>AGT	p.T4920S	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	1043							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGTCTTTAGTTTCAGGAAC	0.428													7	55					0	0	0	0	C	179612368	C	C	179612368	3	2	116	1	0	0	0	0	1	0	0	0	16803	1029	36	4	95538	4	TTN	2	179612368	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	57803	179612368	63587005	65	20762											
PLCL1	5334	broad.mit.edu	37	chr2	198950579	198950579	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgataatcctatttttgatGaaacttttgagttccaagta	12	17	7	5	0	0	4	0	4	0	0	2	4	2	4	2	0	1	2	2	0	5	8			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:198950579G>A	uc010fsp.2	+	2	2629	c.2338G>A	c.(2338-2340)GAA>AAA	p.E780K	PLCL1_uc002uuv.3_Missense_Mutation_p.E701K	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	780	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TATTTTTGATGAAACTTTTGA	0.388													18	75					0	0	0	0	A	198950579	A	A	198950579	3	1	116	1	0	0	0	0	1	0	0	0	12094	1291	45	2	2344	2	PLCL1	2	198950579	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	19338211	198950579	44248794	66	20763											
BMPR2	659	broad.mit.edu	37	chr2	203397344	203397344	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatggcaccagaagtgctaGaaggagctgtgaacttgagg	13	8	14	6	0	0	4	0	2	0	2	0	5	0	5	1	3	3	3	1	3	5	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:203397344G>C	uc002uzf.3	+	9	2313	c.1165G>C	c.(1165-1167)GAA>CAA	p.E389Q	BMPR2_uc010ftr.2_Missense_Mutation_p.E389Q	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	389	Protein kinase.|Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						AGAAGTGCTAGAAGGAGCTGT	0.333													7	35					0	0	0	0	C	203397344	C	C	203397344	3	2	116	1	0	0	0	0	1	0	0	0	1474	943	33	2	1199	2	BMPR2	2	203397344	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	4446765	203397344	39802029	67	20764											
ANKZF1	55139	broad.mit.edu	37	chr2	220098917	220098917	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacactggaaaacagtaagaGaggagagaaagaagcctact	19	4	11	7	0	0	3	0	0	0	3	0	7	0	5	1	2	3	1	1	2	6	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:220098917G>C	uc002vkg.2	+	9	1285	c.1111G>C	c.(1111-1113)GAG>CAG	p.E371Q	ANKZF1_uc010zkv.1_Missense_Mutation_p.E315Q|ANKZF1_uc010zkw.1_Missense_Mutation_p.E161Q|ANKZF1_uc002vkh.2_Missense_Mutation_p.E161Q|ANKZF1_uc002vki.2_Missense_Mutation_p.E371Q|ANKZF1_uc002vkj.1_Missense_Mutation_p.E359Q	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	371						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AACAGTAAGAGAGGAGAGAAA	0.458													11	31					0	0	0	0	C	220098917	C	C	220098917	3	2	116	1	0	0	0	0	1	0	0	0	693	943	33	2	1141	2	ANKZF1	2	220098917	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	16701573	220098917	23100456	68	20765											
ANKZF1	55139	broad.mit.edu	37	chr2	220098992	220098992	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaagcgctggggcagaatGaggaatctcccaaacagggt	13	5	15	8	1	1	2	0	1	1	1	2	4	1	4	1	5	2	2	1	5	4	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:220098992G>A	uc002vkg.2	+	9	1360	c.1186G>A	c.(1186-1188)GAG>AAG	p.E396K	ANKZF1_uc010zkv.1_Missense_Mutation_p.E340K|ANKZF1_uc010zkw.1_Missense_Mutation_p.E186K|ANKZF1_uc002vkh.2_Missense_Mutation_p.E186K|ANKZF1_uc002vki.2_Missense_Mutation_p.E396K|ANKZF1_uc002vkj.1_Missense_Mutation_p.E384K	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	396						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGCAGAATGAGGAATCTCC	0.438													24	67					0	0	0	0	A	220098992	A	A	220098992	3	1	116	1	0	0	0	0	1	0	0	0	693	1291	45	2	1216	2	ANKZF1	2	220098992	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	75	220098992	23100381	69	20766											
CHPF	79586	broad.mit.edu	37	chr2	220408002	220408002	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtggtagggcaagacgcGcggctcccaattctccccgg	7	6	15	13	4	1	1	0	0	1	1	3	1	2	1	3	5	0	3	3	5	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:220408002G>A	uc002vmc.3	-	1	486	c.259C>T	c.(259-261)CGC>TGC	p.R87C	CHPF_uc010zlh.1_5'Flank|CHPF_uc002vmd.3_Missense_Mutation_p.R87C|TMEM198_uc002vme.2_5'Flank|TMEM198_uc002vmf.2_5'Flank	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	87	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GGCAAGACGCGCGGCTCCCAA	0.746													5	25					0	0	0	0	A	220408002	A	A	220408002	3	1	116	1	0	0	0	0	1	0	0	0	3383	1087	38	1	2084	1	CHPF	2	220408002	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	309010	220408002	22791371	70	20767											
CHPF	79586	broad.mit.edu	37	chr2	220408070	220408070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctccgctccgggctgcaccGagttgggccggcgcgccgcg	2	5	17	17	8	0	0	0	0	0	0	2	1	2	0	5	3	1	5	5	3	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:220408070G>A	uc002vmc.3	-	1	418	c.191C>T	c.(190-192)TCG>TTG	p.S64L	CHPF_uc010zlh.1_5'Flank|CHPF_uc002vmd.3_Missense_Mutation_p.S64L|TMEM198_uc002vme.2_5'Flank|TMEM198_uc002vmf.2_5'Flank	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	64	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GGGCTGCACCGAGTTGGGCCG	0.756													7	19					0	0	0	0	A	220408070	A	A	220408070	3	1	116	1	0	0	0	0	1	0	0	0	3383	1059	37	1	2152	1	CHPF	2	220408070	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	68	220408070	22791303	71	20768											
EPHA4	2043	broad.mit.edu	37	chr2	222428965	222428965	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctattgcagtccctcaaggtGaatttaatctcaatatacac	13	13	5	10	0	2	1	2	1	1	0	4	1	3	1	1	1	2	1	1	1	7	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:222428965G>A	uc002vmq.2	-	3	351	c.309C>T	c.(307-309)TTC>TTT	p.F103F	EPHA4_uc002vmr.2_Silent_p.F103F|EPHA4_uc010zlm.1_Silent_p.F44F|EPHA4_uc010zln.1_Silent_p.F103F	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	103	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CCCTCAAGGTGAATTTAATCT	0.473													19	87					0	0	0	0	A	222428965	A	A	222428965	2	1	116	1	0	0	0	0	0	0	0	1	5193	1281	45	2		2	EPHA4	2	222428965	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2020895	222428965	20770408	72	20769											
GPR55	9290	broad.mit.edu	37	chr2	231774833	231774833	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtagcagaaaacatccaggCagcagttgacgttggagaaa	16	6	12	7	1	0	3	0	1	0	2	1	4	1	3	1	2	3	6	1	2	4	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:231774833C>T	uc002vrg.2	-	2	1038	c.845G>A	c.(844-846)TGC>TAC	p.C282Y	GPR55_uc002vrf.2_RNA|GPR55_uc010fxs.1_Missense_Mutation_p.C282Y	NM_005683	NP_005674	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	282	Helical; Name=7; (Potential).				activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		AACATCCAGGCAGCAGTTGAC	0.512													24	80					0	0	0	0	T	231774833	T	T	231774833	3	4	116	1	0	0	0	0	1	0	0	0	6737	710	25	4	118	4	GPR55	2	231774833	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	9345868	231774833	11424540	73	20770											
B3GNT7	93010	broad.mit.edu	37	chr2	232262649	232262649	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtggctgcgcccacgccCatggcctctcaggggcccca	5	6	13	17	2	1	0	1	0	1	0	2	1	1	0	5	4	1	1	5	4	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:232262649C>T	uc002vrs.2	+	2	399	c.219C>T	c.(217-219)CCC>CCT	p.P73P		NM_145236	NP_660279	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal	73	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		CGCCCACGCCCATGGCCTCTC	0.617													15	54					0	0	0	0	T	232262649	T	T	232262649	2	4	116	1	0	0	0	0	0	0	0	1	1264	581	21	4		4	B3GNT7	2	232262649	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	487816	232262649	10936724	74	20771											
DIS3L2	129563	broad.mit.edu	37	chr2	233164768	233164768	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctaaagcttgctttcactCtggaccacgagaccggattg	10	10	10	11	2	2	1	1	0	1	1	2	4	2	3	2	2	3	3	2	2	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:233164768C>G	uc010fxz.2	+	14	1954	c.1678C>G	c.(1678-1680)CTG>GTG	p.L560V	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	560							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		TGCTTTCACTCTGGACCACGA	0.423													9	37					0	0	0	0	G	233164768	G	G	233164768	3	3	116	1	0	0	0	0	1	0	0	0	4559	912	32	2	1728	2	DIS3L2	2	233164768	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	902119	233164768	10034605	75	20772											
HES6	55502	broad.mit.edu	37	chr2	239148343	239148343	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccgcagctcctgcaggctctCgttgatccgcgcgcgccgct	3	8	12	18	7	1	1	0	1	1	0	4	1	3	1	4	1	2	6	4	1	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr2:239148343C>G	uc002vxz.2	-	2	262	c.127G>C	c.(127-129)GAG>CAG	p.E43Q	HES6_uc002vya.2_Missense_Mutation_p.E43Q|HES6_uc002vyb.2_Missense_Mutation_p.E43Q	NM_018645	NP_061115	Q96HZ4	HES6_HUMAN	hairy and enhancer of split 6 isoform a	43	Helix-loop-helix motif.				cell differentiation	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1		Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.23e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.29e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.19e-08)|BRCA - Breast invasive adenocarcinoma(100;5.98e-05)|Lung(119;0.0086)|LUSC - Lung squamous cell carcinoma(224;0.0148)		TGCAGGCTCTCGTTGATCCGC	0.512													2	9					0	0	0	0	G	239148343	G	G	239148343	3	3	116	1	0	0	0	0	1	0	0	0	7109	893	31	3	559	3	HES6	2	239148343	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	5983575	239148343	4051030	76	20773											
LMCD1	29995	broad.mit.edu	37	chr3	8607273	8607273	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttctggaaggatggtgcAccctggtgcggccgccatta	7	10	13	11	2	1	0	0	0	1	0	1	2	1	2	3	5	3	1	3	5	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:8607273A>C	uc003bqq.2	+	5	993	c.879A>C	c.(877-879)GCA>GCC	p.A293A	LMCD1_uc011atd.1_Silent_p.A220A|LMCD1_uc011ate.1_Silent_p.A181A	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	293	LIM zinc-binding 1.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		AGGATGGTGCACCCTGGTGCG	0.632													8	18					0	0	0	0	C	8607273	C	C	8607273	2	2	116	1	0	0	0	0	0	0	0	1	8886	146	6	5		5	LMCD1	3	8607273	Silent	SNP	A	TCGA-CR-5248-01A-01D-2012-08		8607273	189415157	77	20774											
RARB	5915	broad.mit.edu	37	chr3	25634998	25634998	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttttttccttccagattcTtagaatttgcaccaggtata	9	19	5	8	0	1	2	0	0	1	2	3	2	3	2	3	1	1	2	3	1	4	10			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:25634998T>G	uc011awl.1	+	6	878	c.812T>G	c.(811-813)CTT>CGT	p.L271R	RARB_uc003cdi.1_Missense_Mutation_p.L152R|RARB_uc003cdh.2_Missense_Mutation_p.L264R	NM_016152	NP_057236	P10826	RARB_HUMAN	retinoic acid receptor, beta isoform 2	271	Ligand-binding.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	TTCCAGATTCTTAGAATTTGC	0.408													14	26					0	0	0	0	G	25634998	G	G	25634998	3	3	116	1	0	0	0	0	1	0	0	0	13118	1609	56	5	813	5	RARB	3	25634998	Missense_Mutation	SNP	T	TCGA-CR-5248-01A-01D-2012-08	17027725	25634998	172387432	78	20775											
CMTM8	152189	broad.mit.edu	37	chr3	32398904	32398904	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacgcttattgctggaactGagtacttccgggtccccgca	7	10	12	12	3	0	1	0	1	0	0	2	3	2	3	3	3	3	4	3	3	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:32398904G>C	uc003cex.2	+	2	481	c.187G>C	c.(187-189)GAG>CAG	p.E63Q	CMTM8_uc010hfu.2_Intron	NM_178868	NP_849199	Q8IZV2	CKLF8_HUMAN	CKLF-like MARVEL transmembrane domain containing	63	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0						TGCTGGAACTGAGTACTTCCG	0.473													3	79					0	0	0	0	C	32398904	C	C	32398904	3	2	116	1	0	0	0	0	1	0	0	0	3604	1291	45	2	193	2	CMTM8	3	32398904	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	6763906	32398904	165623526	79	20776											
CRTAP	10491	broad.mit.edu	37	chr3	33171442	33171442	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtttcagatcattatgtaGaagttctggaatgcaaaata	14	15	8	4	0	3	2	2	0	1	2	3	3	3	3	0	1	1	4	0	1	7	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:33171442G>C	uc003cfl.3	+	4	925	c.805G>C	c.(805-807)GAA>CAA	p.E269Q	CRTAP_uc010hfz.2_Intron|CRTAP_uc003cfm.2_Missense_Mutation_p.E90Q|CRTAP_uc003cfn.2_Missense_Mutation_p.E90Q	NM_006371	NP_006362	O75718	CRTAP_HUMAN	cartilage associated protein precursor	269						proteinaceous extracellular matrix	binding				0						TCATTATGTAGAAGTTCTGGA	0.373													4	49					0	0	0	0	C	33171442	C	C	33171442	3	2	116	1	0	0	0	0	1	0	0	0	3913	943	33	2	819	2	CRTAP	3	33171442	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	772538	33171442	164850988	80	20777											
MLH1	4292	broad.mit.edu	37	chr3	37048481	37048481	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgttatattttctcattaGagcaagttactcagatggaa	12	17	7	5	0	2	2	2	0	1	2	3	3	2	3	0	1	2	3	0	1	6	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:37048481G>C	uc003cgl.2	+	5	441	c.381_splice	c.e5-1	p.R127_splice	MLH1_uc011aye.1_Splice_Site|MLH1_uc011ayb.1_Splice_Site|MLH1_uc010hge.2_Splice_Site_p.R127_splice|MLH1_uc003cgn.3_Splice_Site|MLH1_uc011ayc.1_Splice_Site_p.R29_splice|MLH1_uc011ayd.1_Splice_Site|MLH1_uc003cgo.2_Splice_Site	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1						mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						TTTCTCATTAGAGCAAGTTAC	0.368		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				13	21					0	0	0	0	C	37048481	C	C	37048481	5	2	116	1	0	0	0	0	0	0	1	0	9670	956	33	2	398	2	MLH1	3	37048481	Splice_Site	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3877039	37048481	160973949	81	20778											
GOLGA4	2803	broad.mit.edu	37	chr3	37367779	37367779	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaattgcagatccagcttGagttaaaatcaaaggaagct	17	9	9	6	0	1	3	1	1	0	2	2	4	2	4	1	1	3	4	1	1	6	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:37367779G>C	uc003cgv.2	+	14	4706	c.4402G>C	c.(4402-4404)GAG>CAG	p.E1468Q	GOLGA4_uc010hgr.1_Missense_Mutation_p.E1029Q|GOLGA4_uc003cgw.2_Missense_Mutation_p.E1490Q|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.E1349Q	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	1468	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GATCCAGCTTGAGTTAAAATC	0.343													4	45					0	0	0	0	C	37367779	C	C	37367779	3	2	116	1	0	0	0	0	1	0	0	0	6592	1291	45	2	4526	2	GOLGA4	3	37367779	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	319298	37367779	160654651	82	20779											
TDGF1	6997	broad.mit.edu	37	chr3	46620773	46620773	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcggggatacctggccttcaGagatgacagcatttggcccc	8	9	12	12	1	1	2	1	1	0	1	2	4	1	3	4	4	2	1	4	4	1	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:46620773G>C	uc003cpv.2	+	3	420	c.140G>C	c.(139-141)AGA>ACA	p.R47T	LRRC2_uc003cpu.3_Intron	NM_003212	NP_003203	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	47					activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		CTGGCCTTCAGAGATGACAGC	0.527													7	33					0	0	0	0	C	46620773	C	C	46620773	3	2	116	1	0	0	0	0	1	0	0	0	15792	942	33	2	150	2	TDGF1	3	46620773	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	9252994	46620773	151401657	83	20780											
MON1A	84315	broad.mit.edu	37	chr3	49948247	49948247	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgcgccagctcttgtgcCgactgccgcgtacgagccac	5	8	11	17	5	1	0	0	0	1	0	2	2	2	0	5	0	6	2	5	0	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:49948247C>T	uc003cxz.2	-	4	1101	c.975G>A	c.(973-975)TCG>TCA	p.S325S	MON1A_uc003cya.2_Silent_p.S163S|MON1A_uc003cyb.2_Silent_p.S163S	NM_032355	NP_115731	Q86VX9	MON1A_HUMAN	MON1 homolog A isoform a	228							protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCTCTTGTGCCGACTGCCGCG	0.582													7	19					0	0	0	0	T	49948247	T	T	49948247	2	4	116	1	0	0	0	0	0	0	0	1	9751	639	23	1		1	MON1A	3	49948247	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3327474	49948247	148074183	84	20781											
CISH	1154	broad.mit.edu	37	chr3	50645484	50645484	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgaacaggtagctggggtGcgtgctgtcacgtactaaga	9	9	15	8	3	1	2	1	1	0	1	1	2	1	2	0	3	5	4	0	3	4	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:50645484G>A	uc003dax.2	-	3	512	c.331C>T	c.(331-333)CAC>TAC	p.H111Y	CISH_uc010hlq.2_Missense_Mutation_p.H128Y	NM_145071	NP_659508	Q9NSE2	CISH_HUMAN	cytokine-inducible SH2-containing protein	111	SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of cell growth	intracellular					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		TAGCTGGGGTGCGTGCTGTCA	0.567													14	37					0	0	0	0	A	50645484	A	A	50645484	3	1	116	1	0	0	0	0	1	0	0	0	3452	1319	46	4	449	4	CISH	3	50645484	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	697237	50645484	147376946	85	20782											
PHF7	51533	broad.mit.edu	37	chr3	52454998	52454998	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagctgcatcttatgttgtGaagacttatcccaacagagt	13	12	8	8	0	1	3	0	1	1	2	2	3	2	3	1	0	3	3	1	0	5	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:52454998G>A	uc003ddy.2	+	7	1299	c.493G>A	c.(493-495)GAA>AAA	p.E165K	PHF7_uc003ddz.2_Missense_Mutation_p.E165K	NM_016483	NP_057567	Q9BWX1	PHF7_HUMAN	PHD finger protein 7 isoform 1	165	RING-type; degenerate.					nucleus	zinc ion binding			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		CTTATGTTGTGAAGACTTATC	0.493													32	80					0	0	0	0	A	52454998	A	A	52454998	3	1	116	1	0	0	0	0	1	0	0	0	11894	1291	45	2	515	2	PHF7	3	52454998	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1809514	52454998	145567432	86	20783											
OR5H6	79295	broad.mit.edu	37	chr3	97983934	97983934	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atctgtatctttatactatgGccccctcaccttcaaatatc	10	15	3	13	0	4	0	2	0	2	0	5	0	4	0	3	1	1	1	3	1	6	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:97983934G>A	uc003dsi.1	+	1	806	c.806G>A	c.(805-807)GGC>GAC	p.G269D		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	269	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						TTATACTATGGCCCCCTCACC	0.398													13	49					0	0	0	0	A	97983934	A	A	97983934	3	1	116	1	0	0	0	0	1	0	0	0	11217	1203	42	4	808	4	OR5H6	3	97983934	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	45528936	97983934	100038496	87	20784											
ZBTB11	27107	broad.mit.edu	37	chr3	101373663	101373663	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcaaaggtacttggactCtcctattagaaaaaattaaa	17	11	7	6	0	1	2	0	1	1	1	2	3	1	3	1	2	2	2	1	2	9	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:101373663C>A	uc003dve.3	-	8	2424	c.2194G>T	c.(2194-2196)GAG>TAG	p.E732*		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	732					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TACTTGGACTCTCCTATTAGA	0.343													5	54					0.000602214	0.000806636	1	0	A	101373663	A	A	101373663	4	1	116	1	0	0	0	0	0	1	0	0	17591	922	32	2	983	2	ZBTB11	3	101373663	Nonsense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3389729	101373663	96648767	88	20785											
ATP1B3	483	broad.mit.edu	37	chr3	141622545	141622545	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgggttatgcttcagactCtcaacgatgaggttccaaaa	11	12	10	8	1	2	2	2	1	1	1	4	3	3	2	1	2	2	3	1	2	4	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:141622545C>G	uc003eug.1	+	2	367	c.193C>G	c.(193-195)CTC>GTC	p.L65V	ATP1B3_uc011bne.1_RNA|ATP1B3_uc003euh.1_Missense_Mutation_p.L51V	NM_001679	NP_001670	P54709	AT1B3_HUMAN	Na+/K+ -ATPase beta 3 subunit	65	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity				0						GCTTCAGACTCTCAACGATGA	0.343													12	110					0	0	0	0	G	141622545	G	G	141622545	3	3	116	1	0	0	0	0	1	0	0	0	1136	913	32	2	199	2	ATP1B3	3	141622545	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	40248882	141622545	56399885	89	20786											
HPS3	84343	broad.mit.edu	37	chr3	148858878	148858878	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccctggaacttcttggtGaaaaaagtgaacagtctgga	13	9	11	8	0	2	2	0	2	2	0	2	4	2	4	2	3	3	0	2	3	5	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:148858878G>T	uc003ewu.1	+	3	927	c.787G>T	c.(787-789)GAA>TAA	p.E263*	HPS3_uc003ewt.1_Nonsense_Mutation_p.E263*|HPS3_uc011bnq.1_Nonsense_Mutation_p.E98*	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	263						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			ACTTCTTGGTGAAAAAAGTGA	0.383									Hermansky-Pudlak_syndrome				13	73					2.27111e-07	3.15042e-07	1	0	T	148858878	T	T	148858878	4	4	116	1	0	0	0	0	0	1	0	0	7379	1291	45	2	797	2	HPS3	3	148858878	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7236333	148858878	49163552	90	20787											
IGSF10	285313	broad.mit.edu	37	chr3	151154852	151154852	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatatagtttcctctgtcAtaagctgttgcttctttaat	9	18	6	8	0	3	1	1	0	2	1	4	1	4	1	1	0	2	4	1	0	4	8			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:151154852A>G	uc011bod.1	-	6	7497	c.7497T>C	c.(7495-7497)TAT>TAC	p.Y2499Y	IGSF10_uc011bob.1_Silent_p.Y526Y|IGSF10_uc011boc.1_Silent_p.Y478Y	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2499	Ig-like C2-type 11.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTCCTCTGTCATAAGCTGTTG	0.393													8	167					0	0	0	0	G	151154852	G	G	151154852	2	3	116	1	0	0	0	0	0	0	0	1	7636	224	8	5		5	IGSF10	3	151154852	Silent	SNP	A	TCGA-CR-5248-01A-01D-2012-08	2295974	151154852	46867578	91	20788											
LEKR1	389170	broad.mit.edu	37	chr3	156763471	156763471	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacatcctcccaggggtggaGcatcttcagcaaatgagact	11	8	10	12	0	2	1	1	1	1	1	4	3	4	2	2	3	2	2	2	3	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:156763471G>T	uc003fba.1	+	14	2434	c.1099G>T	c.(1099-1101)GCA>TCA	p.A367S		NM_001004316	NP_001004316	Q6ZMV7	LEKR1_HUMAN	leucine, glutamate and lysine rich 1	Error:Variant_position_missing_in_D3DNK7_after_alignment											0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CAGGGGTGGAGCATCTTCAGC	0.547													19	110					5.26018e-13	7.43812e-13	1	0	T	156763471	T	T	156763471	3	4	116	1	0	0	0	0	1	0	0	0	8757	971	34	4	2057	4	LEKR1	3	156763471	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5608619	156763471	41258959	92	20789											
VEPH1	79674	broad.mit.edu	37	chr3	157146231	157146231	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctattaattggctgaggCtgcttttcatacacagcagg	9	14	10	8	0	2	1	1	1	1	0	2	1	2	1	0	3	3	4	0	3	3	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:157146231C>T	uc003fbj.1	-	5	893	c.576G>A	c.(574-576)CAG>CAA	p.Q192Q	VEPH1_uc003fbk.1_Silent_p.Q192Q|VEPH1_uc010hvu.1_Silent_p.Q192Q	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	192						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TTGGCTGAGGCTGCTTTTCAT	0.458													19	59					0	0	0	0	T	157146231	T	T	157146231	2	4	116	1	0	0	0	0	0	0	0	1	17222	796	28	4		4	VEPH1	3	157146231	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	382760	157146231	40876199	93	20790											
SLITRK3	22865	broad.mit.edu	37	chr3	164908029	164908029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaggtccaaatgggttaaaGagacagccttaaataaattg	16	10	10	5	0	0	1	0	0	0	1	1	2	1	1	2	2	1	2	2	2	8	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:164908029G>C	uc003fej.3	-	2	1034	c.590C>G	c.(589-591)TCT>TGT	p.S197C	SLITRK3_uc003fek.2_Missense_Mutation_p.S197C	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	197	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						ATGGGTTAAAGAGACAGCCTT	0.413										HNSCC(40;0.11)			13	68					0	0	0	0	C	164908029	C	C	164908029	3	2	116	1	0	0	0	0	1	0	0	0	14808	942	33	2	2347	2	SLITRK3	3	164908029	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7761798	164908029	33114401	94	20791											
EIF2B5	8893	broad.mit.edu	37	chr3	183861986	183861986	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggacttcttcctagagcatGaagctcttggtatttccatg	9	14	9	9	0	2	2	0	1	2	1	4	3	4	3	2	2	2	3	2	2	3	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:183861986G>A	uc003fmp.2	+	14	2333	c.1969G>A	c.(1969-1971)GAA>AAA	p.E657K	EIF2B5_uc003fmq.2_Missense_Mutation_p.E378K|EIF2B5_uc003fmr.2_Missense_Mutation_p.E65K	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,	657	W2.				astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CCTAGAGCATGAAGCTCTTGG	0.502													30	171					0	0	0	0	A	183861986	A	A	183861986	3	1	116	1	0	0	0	0	1	0	0	0	5026	1291	45	2	2023	2	EIF2B5	3	183861986	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	18953957	183861986	14160444	95	20792											
FAM131A	131408	broad.mit.edu	37	chr3	184060556	184060556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgagcagtttgccatcgCggaagccaagctccgagcat	9	7	13	12	3	0	1	0	1	0	0	2	3	1	2	3	2	5	5	3	2	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:184060556C>T	uc003fog.2	+	2	1804	c.440C>T	c.(439-441)GCG>GTG	p.A147V	FAM131A_uc003fob.1_Missense_Mutation_p.A55V|FAM131A_uc003foc.2_Missense_Mutation_p.A93V|FAM131A_uc003foe.2_Missense_Mutation_p.A93V	NM_144635	NP_653236	Q6UXB0	F131A_HUMAN	hypothetical protein LOC131408 precursor	147						extracellular region				breast(1)	1	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTTGCCATCGCGGAAGCCAAG	0.557													12	40					0	0	0	0	T	184060556	T	T	184060556	3	4	116	1	0	0	0	0	1	0	0	0	5467	768	27	1	551	1	FAM131A	3	184060556	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	198570	184060556	13961874	96	20793											
LPP	4026	broad.mit.edu	37	chr3	188327198	188327198	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttaatgtgcaggtgaagTcagcccagcccagccctcat	9	9	9	14	0	2	1	2	1	0	0	2	1	2	1	4	1	4	1	4	1	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:188327198T>G	uc003frs.1	+	6	925	c.679T>G	c.(679-681)TCA>GCA	p.S227A	LPP_uc011bsg.1_Intron|LPP_uc011bsi.1_Missense_Mutation_p.S227A|LPP_uc003frt.2_Missense_Mutation_p.S227A|LPP_uc011bsj.1_Missense_Mutation_p.S64A	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	227	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GCAGGTGAAGTCAGCCCAGCC	0.562			T	HMGA2|MLL|C12orf9	lipoma|leukemia								11	92					0	0	0	0	G	188327198	G	G	188327198	3	3	116	1	0	0	0	0	1	0	0	0	8973	1667	58	5	693	5	LPP	3	188327198	Missense_Mutation	SNP	T	TCGA-CR-5248-01A-01D-2012-08	4266642	188327198	9695232	97	20794											
CPN2	1370	broad.mit.edu	37	chr3	194063020	194063020	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caggtgctggaaaagaccctCgggcagagcctccagcatgt	10	6	13	12	1	0	2	0	0	0	2	2	3	1	3	3	3	3	3	3	3	2	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr3:194063020C>G	uc003fts.2	-	2	502	c.412G>C	c.(412-414)GAG>CAG	p.E138Q		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	138	LRR 2.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		AAAAGACCCTCGGGCAGAGCC	0.607													5	89					0	0	0	0	G	194063020	G	G	194063020	3	3	116	1	0	0	0	0	1	0	0	0	3825	893	31	3	1229	3	CPN2	3	194063020	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	5735822	194063020	3959410	98	20795											
PCGF3	10336	broad.mit.edu	37	chr4	728799	728799	+	Frame_Shift_Del	DEL	C	-	-																															attgtgatccaccagagccaCcccctgcagtacatcgggtg																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:728799delC	uc011bva.1	+	6	664	c.189delC	c.(187-189)CACfs	p.H63fs	PCGF3_uc003gbc.1_RNA|PCGF3_uc003gbd.1_RNA|PCGF3_uc003gbe.2_Frame_Shift_Del_p.H63fs|PCGF3_uc010ibh.2_Frame_Shift_Del_p.H63fs|PCGF3_uc003gbg.1_Frame_Shift_Del_p.H29fs|PCGF3_uc003gbh.2_Frame_Shift_Del_p.H29fs	NM_006315	NP_006306	Q3KNV8	PCGF3_HUMAN	ring finger protein 3	63					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	zinc ion binding				0						ACCAGAGCCACCCCCTGCAGT	0.607													---	---	---								-	728799	-	-	728799	7	5	116	1	0	1	0	1	0	0	0	0	11630	506	18	0	195	0	PCGF3	4	728799	Frame_Shift_Del	DEL	C	TCGA-CR-5248-01A-01D-2012-08		728799	190425477	99	20796											
SLIT2	9353	broad.mit.edu	37	chr4	20530585	20530585	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaataggtacagaagattaTcgatcaaaattaagtggaga	18	10	9	4	1	2	3	2	0	0	3	3	5	2	3	0	2	1	1	0	2	8	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:20530585T>C	uc003gpr.1	+	16	1680	c.1476T>C	c.(1474-1476)TAT>TAC	p.Y492Y	SLIT2_uc003gps.1_Silent_p.Y484Y	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	492					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						CAGAAGATTATCGATCAAAAT	0.353													13	51					0	0	0	0	C	20530585	C	C	20530585	2	2	116	1	0	0	0	0	0	0	0	1	14804	1442	50	5		5	SLIT2	4	20530585	Silent	SNP	T	TCGA-CR-5248-01A-01D-2012-08	19801786	20530585	170623691	100	20797											
SEL1L3	23231	broad.mit.edu	37	chr4	25792177	25792177	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtatttcatcatcttttagtCtaattgtttcaacatatgcc	10	19	4	8	0	5	0	3	0	2	0	5	0	5	0	1	0	2	2	1	0	5	8			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:25792177C>G	uc003gru.3	-	12	2128	c.1976G>C	c.(1975-1977)AGA>ACA	p.R659T	SEL1L3_uc003grv.2_Missense_Mutation_p.R66T	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	659						integral to membrane	binding				0						ATCTTTTAGTCTAATTGTTTC	0.249													13	41					0	0	0	0	G	25792177	G	G	25792177	3	3	116	1	0	0	0	0	1	0	0	0	14077	913	32	2	1474	2	SEL1L3	4	25792177	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	5261592	25792177	165362099	101	20798											
FRYL	285527	broad.mit.edu	37	chr4	48608509	48608509	+	Frame_Shift_Del	DEL	A	-	-																															acaggatacatttttactcgAaaaaatttcattcccattat																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:48608509delA	uc003gyh.1	-	10	1292	c.687delT	c.(685-687)TTTfs	p.F229fs	FRYL_uc003gyk.2_Frame_Shift_Del_p.F229fs	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TTTTTACTCGAAAAAATTTCA	0.348													---	---	---								-	48608509	-	-	48608509	7	5	116	1	0	1	0	1	0	0	0	0	6098	243	9	0	8574	0	FRYL	4	48608509	Frame_Shift_Del	DEL	A	TCGA-CR-5248-01A-01D-2012-08	22816332	48608509	142545767	102	20799											
LRRC66	339977	broad.mit.edu	37	chr4	52861239	52861239	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacctcgctgtagtgggctGaaagcgcttcctcagccctt	7	10	11	13	2	1	1	1	1	0	0	3	2	2	1	3	1	3	4	3	1	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:52861239G>A	uc003gzi.2	-	4	1962	c.1949C>T	c.(1948-1950)TCA>TTA	p.S650L		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	650						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GTAGTGGGCTGAAAGCGCTTC	0.532													16	40					0	0	0	0	A	52861239	A	A	52861239	3	1	116	1	0	0	0	0	1	0	0	0	9068	1294	45	2	697	2	LRRC66	4	52861239	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	4252730	52861239	138293037	103	20800											
CLOCK	9575	broad.mit.edu	37	chr4	56301653	56301653	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgagttgctgctgttgctGagactgatgttgctggtgat	5	15	15	6	0	0	4	0	4	0	1	0	5	0	4	0	1	4	8	0	1	0	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:56301653G>A	uc003haz.1	-	24	3396	c.2470C>T	c.(2470-2472)CAG>TAG	p.Q824*	CLOCK_uc003hba.1_Nonsense_Mutation_p.Q824*|CLOCK_uc010igu.1_RNA	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	824	Poly-Gln.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			TGCTGTTGCTGAGACTGATGT	0.527													25	56					0	0	0	0	A	56301653	A	A	56301653	4	1	116	1	0	0	0	0	0	1	0	0	3564	1299	45	2	74	2	CLOCK	4	56301653	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3440414	56301653	134852623	104	20801											
TECRL	253017	broad.mit.edu	37	chr4	65274945	65274945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtcttagagggcccgctGagagtacaagttttgacaaa	11	11	12	7	1	1	3	0	2	1	2	1	4	1	3	1	2	1	3	1	2	4	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:65274945G>A	uc003hcv.2	-	1	234	c.125C>T	c.(124-126)TCA>TTA	p.S42L	TECRL_uc003hcw.2_Missense_Mutation_p.S42L	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	42					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						AGGGCCCGCTGAGAGTACAAG	0.393													8	28					0	0	0	0	A	65274945	A	A	65274945	3	1	116	1	0	0	0	0	1	0	0	0	15812	1294	45	2	1014	2	TECRL	4	65274945	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	8973292	65274945	125879331	105	20802											
FAM190A	401145	broad.mit.edu	37	chr4	91230678	91230678	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagggatccatcctatttcaGattcaaagataatacctact	15	12	5	9	0	2	2	2	0	0	2	4	3	4	3	3	1	2	0	3	1	6	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:91230678G>C	uc003hsv.3	+	2	1583	c.1243G>C	c.(1243-1245)GAT>CAT	p.D415H	FAM190A_uc003hsu.3_Missense_Mutation_p.D415H|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.D415H	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	415										large_intestine(1)|ovary(1)	2						TCCTATTTCAGATTCAAAGAT	0.363													22	34					0	0	0	0	C	91230678	C	C	91230678	3	2	116	1	0	0	0	0	1	0	0	0	5549	942	33	2	1245	2	FAM190A	4	91230678	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	25955733	91230678	99923598	106	20803											
SMARCAD1	56916	broad.mit.edu	37	chr4	95155231	95155231	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgctaaacttcagactttGaaggaactttttccacaaag	14	12	7	8	0	1	2	1	1	0	1	2	4	2	3	1	1	3	1	1	1	5	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:95155231G>C	uc003htc.3	+	4	750	c.495G>C	c.(493-495)TTG>TTC	p.L165F	SMARCAD1_uc003htb.3_Missense_Mutation_p.L165F|SMARCAD1_uc003htd.3_Missense_Mutation_p.L165F|SMARCAD1_uc010ila.2_Missense_Mutation_p.L28F	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	165	CUE 1.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		ttcagactttgaaggaacttt	0.134													8	18					0	0	0	0	C	95155231	C	C	95155231	3	2	116	1	0	0	0	0	1	0	0	0	14836	1281	45	2	505	2	SMARCAD1	4	95155231	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3924553	95155231	95999045	107	20804											
ANK2	287	broad.mit.edu	37	chr4	114195732	114195732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtacacaccactgcacatctCtgcccgggagggccaggtgg	8	6	13	14	1	1	0	0	0	1	0	2	1	1	1	3	4	3	2	3	4	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:114195732C>T	uc003ibe.3	+	15	1710	c.1610C>T	c.(1609-1611)TCT>TTT	p.S537F	ANK2_uc003ibd.3_Missense_Mutation_p.S516F|ANK2_uc003ibf.3_Missense_Mutation_p.S537F|ANK2_uc003ibc.2_Missense_Mutation_p.S513F|ANK2_uc011cgb.1_Missense_Mutation_p.S552F	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	537	ANK 16.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGCACATCTCTGCCCGGGAG	0.532													22	36					0	0	0	0	T	114195732	T	T	114195732	3	4	116	1	0	0	0	0	1	0	0	0	621	913	32	2	1693	2	ANK2	4	114195732	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	19040501	114195732	76958544	108	20805											
ANKRD50	57182	broad.mit.edu	37	chr4	125590572	125590572	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctgtgaagaattactttgtTtcgcttttttcccagctgat	7	18	8	8	1	0	3	0	2	0	1	2	3	1	3	1	0	2	4	1	0	3	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:125590572T>C	uc003ifg.3	-	3	4126	c.3860A>G	c.(3859-3861)AAA>AGA	p.K1287R	ANKRD50_uc011cgo.1_Missense_Mutation_p.K1108R|ANKRD50_uc010inw.2_Missense_Mutation_p.K1287R	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1287	Ser-rich.									central_nervous_system(1)	1						ATTACTTTGTTTCGCTTTTTT	0.418													4	126					0	0	0	0	C	125590572	C	C	125590572	3	2	116	1	0	0	0	0	1	0	0	0	677	1841	64	5	433	5	ANKRD50	4	125590572	Missense_Mutation	SNP	T	TCGA-CR-5248-01A-01D-2012-08	11394840	125590572	65563704	109	20806											
WDR17	116966	broad.mit.edu	37	chr4	177041161	177041161	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctcatagcttcttgtctGatatctgtatgttcagatgg	8	17	9	7	0	5	2	2	1	3	1	5	2	5	2	0	1	2	4	0	1	3	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr4:177041161G>T	uc003iuj.2	+	5	679	c.523G>T	c.(523-525)GAT>TAT	p.D175Y	WDR17_uc003iuk.2_Missense_Mutation_p.D151Y|WDR17_uc003ium.3_Missense_Mutation_p.D151Y|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	175	WD 3.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CTTCTTGTCTGATATCTGTAT	0.408													32	87					1.88708e-17	2.70776e-17	1	0	T	177041161	T	T	177041161	3	4	116	1	0	0	0	0	1	0	0	0	17345	1290	45	2	537	2	WDR17	4	177041161	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	51450589	177041161	14113115	110	20807											
PLEKHG4B	153478	broad.mit.edu	37	chr5	171516	171516	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctgcttccagctgcgtcAcggcaatgacctgctggcca	6	9	12	14	2	2	1	1	1	1	0	3	1	3	1	3	3	4	4	3	3	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:171516A>G	uc003jak.2	+	14	2989	c.2939A>G	c.(2938-2940)CAC>CGC	p.H980R		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	980	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CAGCTGCGTCACGGCAATGAC	0.667													4	30					0	0	0	0	G	171516	G	G	171516	3	3	116	1	0	0	0	0	1	0	0	0	12127	159	6	5	2993	5	PLEKHG4B	5	171516	Missense_Mutation	SNP	A	TCGA-CR-5248-01A-01D-2012-08		171516	180743744	111	20808											
ZDHHC11	79844	broad.mit.edu	37	chr5	801245	801245	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcttcactttcagcactgtCagttttcatgggctctgttg	5	17	9	10	0	6	0	4	0	2	0	6	0	6	0	0	1	1	4	0	1	0	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:801245C>T	uc011cma.1	-	12	1600	c.1216G>A	c.(1216-1218)GAC>AAC	p.D406N	ZDHHC11_uc010itc.2_RNA|ZDHHC11_uc003jbj.2_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	406						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			TCAGCACTGTCAGTTTTCATG	0.398													11	104					0	0	0	0	T	801245	T	T	801245	3	4	116	1	0	0	0	0	1	0	0	0	17668	826	29	2	26	2	ZDHHC11	5	801245	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	629729	801245	180114015	112	20809											
NSUN2	54888	broad.mit.edu	37	chr5	6605463	6605463	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagctgccttttcttcccttCtgtagtccgagttaacaaat	8	15	7	11	1	2	0	0	0	2	0	4	2	4	0	3	0	3	3	3	0	3	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:6605463C>T	uc003jdu.2	-	15	1725	c.1660G>A	c.(1660-1662)GAA>AAA	p.E554K	NSUN2_uc003jds.2_5'Flank|NSUN2_uc003jdt.2_Missense_Mutation_p.E318K|NSUN2_uc011cmk.1_Missense_Mutation_p.E519K|NSUN2_uc003jdv.2_Missense_Mutation_p.E318K	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	554						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						TTCTTCCCTTCTGTAGTCCGA	0.423													22	155					0	0	0	0	T	6605463	T	T	6605463	3	4	116	1	0	0	0	0	1	0	0	0	10732	922	32	2	663	2	NSUN2	5	6605463	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	5804218	6605463	174309797	113	20810											
DNAH5	1767	broad.mit.edu	37	chr5	13871062	13871062	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgttacagtggcgtccaatGacaaccatccaggcctttgt	9	12	9	11	1	0	1	0	1	0	0	2	1	2	1	4	2	2	1	4	2	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:13871062G>A	uc003jfd.2	-	24	3690	c.3648C>T	c.(3646-3648)GTC>GTT	p.V1216V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1216	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGCGTCCAATGACAACCATCC	0.388									Kartagener_syndrome				14	68					0	0	0	0	A	13871062	A	A	13871062	2	1	116	1	0	0	0	0	0	0	0	1	4626	1277	45	2		2	DNAH5	5	13871062	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7265599	13871062	167044198	114	20811											
TRIO	7204	broad.mit.edu	37	chr5	14291310	14291310	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggaccagtgcttccagctGaggctgtttgaacaggatgc	8	10	13	10	0	0	2	0	2	0	0	1	4	1	4	2	3	4	4	2	3	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:14291310G>A	uc003jff.2	+	5	1032	c.1026G>A	c.(1024-1026)CTG>CTA	p.L342L	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.L293L|TRIO_uc003jfh.1_5'Flank	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	342	Spectrin 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GCTTCCAGCTGAGGCTGTTTG	0.587													18	56					0	0	0	0	A	14291310	A	A	14291310	2	1	116	1	0	0	0	0	0	0	0	1	16619	1277	45	2		2	TRIO	5	14291310	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	420248	14291310	166623950	115	20812											
C1QTNF3	114899	broad.mit.edu	37	chr5	34033476	34033476	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	catgctgcccccgctcccctCgaggccccaggtcacctttg	4	8	9	20	2	1	0	1	0	0	0	3	1	2	0	7	2	2	2	7	2	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:34033476C>G	uc003jin.2	-	3	371	c.284G>C	c.(283-285)CGA>CCA	p.R95P	C1QTNF3_uc003jio.2_Missense_Mutation_p.R168P	NM_030945	NP_112207	Q9BXJ4	C1QT3_HUMAN	C1q and tumor necrosis factor related protein 3	95	Collagen-like.					collagen					0	all_lung(31;0.0207)					CCGCTCCCCTCGAGGCCCCAG	0.562													21	64					0	0	0	0	G	34033476	G	G	34033476	3	3	116	1	0	0	0	0	1	0	0	0	1973	884	31	3	472	3	C1QTNF3	5	34033476	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	19742166	34033476	146881784	116	20813											
PIK3R1	5295	broad.mit.edu	37	chr5	67576368	67576368	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acttgtagaagtacaaagctCcgaagaatatattcagctat	16	11	7	7	1	1	2	1	0	0	2	2	3	2	2	1	0	3	4	1	0	9	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:67576368C>G	uc003jva.2	+	6	1207	c.647C>G	c.(646-648)TCC>TGC	p.S216C	PIK3R1_uc003jvb.2_Missense_Mutation_p.S216C	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	216	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GTACAAAGCTCCGAAGAATAT	0.343			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			26	130					0	0	0	0	G	67576368	G	G	67576368	3	3	116	1	0	0	0	0	1	0	0	0	11973	855	30	2	665	2	PIK3R1	5	67576368	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	33542892	67576368	113338892	117	20814											
PTCD2	79810	broad.mit.edu	37	chr5	71654230	71654230	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtcgcaccttccagccactCagccagtccctgttggctga	6	9	9	17	2	1	1	1	1	0	0	4	1	3	1	5	1	2	3	5	1	0	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:71654230C>G	uc003kcb.2	+	10	1153	c.1143C>G	c.(1141-1143)CTC>CTG	p.L381L	PTCD2_uc011csf.1_Silent_p.L191L|PTCD2_uc003kcc.2_Silent_p.L229L|PTCD2_uc011csg.1_Silent_p.L209L|PTCD2_uc011csh.1_Silent_p.L272L|PTCD2_uc003kcd.2_RNA	NM_024754	NP_079030	Q8WV60	PTCD2_HUMAN	pentatricopeptide repeat domain 2	381											0		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.73e-53)		TCCAGCCACTCAGCCAGTCCC	0.517													5	15					0	0	0	0	G	71654230	G	G	71654230	2	3	116	1	0	0	0	0	0	0	0	1	12790	813	29	2		2	PTCD2	5	71654230	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	4077862	71654230	109261030	118	20815											
THBS4	7060	broad.mit.edu	37	chr5	79355723	79355723	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatcacctgtattgatgttGatgaggtaaaagttcactta	12	14	10	5	0	2	3	2	3	0	0	2	4	2	4	1	2	0	4	1	2	4	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:79355723G>A	uc003kgh.2	+	8	1305	c.982G>A	c.(982-984)GAT>AAT	p.D328N		NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	328	EGF-like 2; calcium-binding (Potential).				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		TATTGATGTTGATGAGGTAAA	0.507													41	102					0	0	0	0	A	79355723	A	A	79355723	3	1	116	1	0	0	0	0	1	0	0	0	15922	1290	45	2	1008	2	THBS4	5	79355723	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7701493	79355723	101559537	119	20816											
ERAP1	51752	broad.mit.edu	37	chr5	96130758	96130758	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctctaccttgtttgggtagGggatacggtatgctgaaata	9	14	12	6	1	1	1	0	1	1	0	2	2	1	2	1	4	3	4	1	4	6	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:96130758G>A	uc003kmm.2	-	5	1253	c.906C>T	c.(904-906)CCC>CCT	p.P302P	ERAP1_uc003kml.2_Silent_p.P302P|ERAP1_uc010jbm.1_Silent_p.P114P|ERAP1_uc003kmn.2_Silent_p.P302P	NM_001040458	NP_001035548	Q9NZ08	ERAP1_HUMAN	type 1 tumor necrosis factor receptor shedding	302	Lumenal (Potential).				angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		GTTTGGGTAGGGGATACGGTA	0.388													4	21					0	0	0	0	A	96130758	A	A	96130758	2	1	116	1	0	0	0	0	0	0	0	1	5227	1219	43	4		4	ERAP1	5	96130758	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	16775035	96130758	84784502	120	20817											
P4HA2	8974	broad.mit.edu	37	chr5	131530707	131530707	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaggttgtaccagaacacAgctgtaccctgggaaagaga	15	6	12	8	0	0	3	0	0	0	3	0	5	0	4	2	2	4	4	2	2	5	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:131530707A>C	uc003kwh.2	-	14	2013	c.1449T>G	c.(1447-1449)GCT>GCG	p.A483A	P4HA2_uc003kwg.2_Silent_p.A481A|P4HA2_uc003kwi.2_Silent_p.A481A|P4HA2_uc003kwk.2_Silent_p.A481A|P4HA2_uc003kwl.2_Silent_p.A483A|P4HA2_uc003kwj.2_Silent_p.A481A	NM_004199	NP_004190	O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha II subunit isoform 1	483	Fe2OG dioxygenase.					endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding				0		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	ACCAGAACACAGCTGTACCCT	0.542													19	52					0	0	0	0	C	131530707	C	C	131530707	2	2	116	1	0	0	0	0	0	0	0	1	11411	175	7	5		5	P4HA2	5	131530707	Silent	SNP	A	TCGA-CR-5248-01A-01D-2012-08	35399949	131530707	49384553	121	20818											
FAM53C	51307	broad.mit.edu	37	chr5	137680625	137680625	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcacctcagaccacccagtcGgggaaactcccccaaggagc	11	3	10	17	1	1	1	1	0	0	1	3	3	2	3	5	3	2	1	5	3	2	0	rs146380618	byFrequency	TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:137680625G>A	uc003lcv.2	+	4	718	c.248G>A	c.(247-249)CGG>CAG	p.R83Q	FAM53C_uc003lcw.2_Missense_Mutation_p.R83Q|FAM53C_uc011cyq.1_Intron|FAM53C_uc011cyr.1_Intron	NM_001135647	NP_001129119	Q9NYF3	FA53C_HUMAN	hypothetical protein LOC51307	83										ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCACCCAGTCGGGGAAACTCC	0.622													24	90					0	0	0	0	A	137680625	A	A	137680625	3	1	116	1	0	0	0	0	1	0	0	0	5613	1116	39	1	258	1	FAM53C	5	137680625	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	6149918	137680625	43234635	122	20819											
PCDHA6	56142	broad.mit.edu	37	chr5	140209601	140209601	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcctggacgaagcggactCtccgcgccaccggctgctgg	5	7	14	15	5	1	0	0	0	1	0	3	3	2	2	4	4	2	2	4	4	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:140209601C>G	uc003lho.2	+	1	1952	c.1925C>G	c.(1924-1926)TCT>TGT	p.S642C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.S642C	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	642	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGCGGACTCTCCGCGCCAC	0.672													25	60					0	0	0	0	G	140209601	G	G	140209601	3	3	116	1	0	0	0	0	1	0	0	0	11582	913	32	2	1927	2	PCDHA6	5	140209601	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2528976	140209601	40705659	123	20820											
PCDHB9	56127	broad.mit.edu	37	chr5	140568326	140568326	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtcagcgccacagacagaGactcaggcaccaacgcccag	12	3	11	15	2	2	2	2	0	0	2	2	3	2	2	3	1	2	1	3	1	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:140568326G>C	uc003liw.1	+	3	1435	c.1435G>C	c.(1435-1437)GAC>CAC	p.D479H		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	479	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACAGACAGAGACTCAGGCAC	0.652													33	236					0	0	0	0	C	140568326	C	C	140568326	3	2	116	1	0	0	0	0	1	0	0	0	11603	933	33	2	1436	2	PCDHB9	5	140568326	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	358725	140568326	40346934	124	20821											
PCDHB9	56127	broad.mit.edu	37	chr5	140568883	140568883	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcacgtgctcctggtggaCggcttctcccagccctacct	4	10	10	17	2	1	0	0	0	1	0	3	1	2	1	4	3	4	3	4	3	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr5:140568883C>T	uc003liw.1	+	3	1992	c.1992C>T	c.(1990-1992)GAC>GAT	p.D664D		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	664	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTGGTGGACGGCTTCTCCC	0.701													6	117					0	0	0	0	T	140568883	T	T	140568883	2	4	116	1	0	0	0	0	0	0	0	1	11603	536	19	1		1	PCDHB9	5	140568883	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	557	140568883	40346377	125	20822											
GFOD1	54438	broad.mit.edu	37	chr6	13487002	13487002	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actcatctccttggccagctCctccgcttcttcctgcgtgc	3	13	7	18	2	3	0	1	0	2	0	7	0	6	0	5	1	3	2	5	1	0	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:13487002C>A	uc003nat.1	-	1	786	c.121G>T	c.(121-123)GAG>TAG	p.E41*	GFOD1_uc003nas.1_5'Flank|C6orf114_uc003nav.2_5'Flank	NM_018988	NP_061861	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain	41						extracellular region	binding|oxidoreductase activity			ovary(2)	2	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			TTGGCCAGCTCCTCCGCTTCT	0.627													25	82					7.38237e-10	1.03141e-09	1	0	A	13487002	A	A	13487002	4	1	116	1	0	0	0	0	0	1	0	0	6380	864	30	2	1059	2	GFOD1	6	13487002	Nonsense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		13487002	157628065	126	20823											
HIST1H4C	8364	broad.mit.edu	37	chr6	26104378	26104378	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttcttagagaacgttattcGagacgccgtcacctatacgg	10	12	9	10	5	2	2	1	0	1	2	3	4	2	2	2	1	2	1	2	1	5	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:26104378G>C	uc003ngi.2	+	1	203	c.203G>C	c.(202-204)CGA>CCA	p.R68P		NM_003542	NP_003533	P62805	H4_HUMAN	histone cluster 1, H4c	68					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						AACGTTATTCGAGACGCCGTC	0.527													10	46					0	0	0	0	C	26104378	C	C	26104378	3	2	116	1	0	0	0	0	1	0	0	0	7206	1058	37	3	205	3	HIST1H4C	6	26104378	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	12617376	26104378	145010689	127	20824											
ZBTB12	221527	broad.mit.edu	37	chr6	31867996	31867996	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttgaactgcttgccacagcGagggcacatgaagatgaagt	12	8	13	8	1	0	4	0	3	0	1	0	5	0	4	1	1	4	3	1	1	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:31867996G>A	uc003nyd.1	-	2	1263	c.1087C>T	c.(1087-1089)CGC>TGC	p.R363C	EHMT2_uc003nxz.1_5'Flank|EHMT2_uc003nya.1_5'Flank|EHMT2_uc003nyb.1_5'Flank|C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_5'Flank	NM_181842	NP_862825	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	363	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGCCACAGCGAGGGCACATG	0.562													20	65					0	0	0	0	A	31867996	A	A	31867996	3	1	116	1	0	0	0	0	1	0	0	0	17592	1058	37	1	296	1	ZBTB12	6	31867996	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5763618	31867996	139247071	128	20825											
ZBTB12	221527	broad.mit.edu	37	chr6	31868111	31868111	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaaggggtttccacctgaGaagcccccaggcaggggtcc	8	8	13	12	0	0	1	0	1	0	1	2	2	2	1	5	5	1	2	5	5	2	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:31868111G>C	uc003nyd.1	-	2	1148	c.972C>G	c.(970-972)TTC>TTG	p.F324L	EHMT2_uc003nxz.1_5'Flank|EHMT2_uc003nya.1_5'Flank|EHMT2_uc003nyb.1_5'Flank|C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_5'Flank	NM_181842	NP_862825	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	324	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCCACCTGAGAAGCCCCCAG	0.483													7	35					0	0	0	0	C	31868111	C	C	31868111	3	2	116	1	0	0	0	0	1	0	0	0	17592	933	33	2	411	2	ZBTB12	6	31868111	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	115	31868111	139246956	129	20826											
KIF6	221458	broad.mit.edu	37	chr6	39330286	39330286	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagaggcacggccatgttttCcgagattcctgtagaaggaa	11	9	12	9	2	0	3	0	0	0	3	2	5	2	4	3	3	0	3	3	3	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:39330286C>T	uc003oot.2	-	17	1965	c.1870G>A	c.(1870-1872)GAA>AAA	p.E624K	KIF6_uc003oos.2_Missense_Mutation_p.E75K|KIF6_uc010jwz.1_5'UTR|KIF6_uc010jxa.1_Missense_Mutation_p.E415K|KIF6_uc011dua.1_Missense_Mutation_p.E607K|KIF6_uc010jxb.1_Missense_Mutation_p.E568K	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	624	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						GCCATGTTTTCCGAGATTCCT	0.512											OREG0017415	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	137					0	0	0	0	T	39330286	T	T	39330286	3	4	116	1	0	0	0	0	1	0	0	0	8347	864	30	2	602	2	KIF6	6	39330286	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	7462175	39330286	131784781	130	20827											
TREM2	54209	broad.mit.edu	37	chr6	41126780	41126780	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggatggaagtgggtgggaaGgggatttctccttccaagag	10	9	17	5	0	1	1	0	0	1	1	3	5	2	5	2	6	0	0	2	6	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:41126780G>A	uc003opy.2	-	4	609	c.507C>T	c.(505-507)CCC>CCT	p.P169P	TREM2_uc003opz.2_Missense_Mutation_p.L213F|TREM2_uc010jxl.1_Intron	NM_018965	NP_061838	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	169	Extracellular (Potential).				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGGTGGGAAGGGGATTTCTC	0.547													6	15					0	0	0	0	A	41126780	A	A	41126780	2	1	116	1	0	0	0	0	0	0	0	1	16538	987	35	4		4	TREM2	6	41126780	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1796494	41126780	129988287	131	20828											
YIPF3	25844	broad.mit.edu	37	chr6	43481162	43481162	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagtgaagaccagcatgaGaggtccatagagttcacctg	13	7	12	9	0	1	5	1	2	0	4	2	6	2	5	3	1	1	2	3	1	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:43481162G>A	uc003ovl.1	-	5	626	c.469C>T	c.(469-471)CTC>TTC	p.L157F	C6orf154_uc003ovk.1_5'Flank|YIPF3_uc011dvk.1_Missense_Mutation_p.L122F|YIPF3_uc010jyr.1_Missense_Mutation_p.L163F|YIPF3_uc010jys.1_5'UTR|YIPF3_uc003ovm.1_Missense_Mutation_p.L31F|YIPF3_uc010jyt.1_Missense_Mutation_p.L106F	NM_015388	NP_056203	Q9GZM5	YIPF3_HUMAN	natural killer cell-specific antigen KLIP1	157	Helical; (Potential).				cell differentiation	integral to membrane|plasma membrane|transport vesicle					0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			ACCAGCATGAGAGGTCCATAG	0.478													6	46					0	0	0	0	A	43481162	A	A	43481162	3	1	116	1	0	0	0	0	1	0	0	0	17547	942	33	2	603	2	YIPF3	6	43481162	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2354382	43481162	127633905	132	20829											
XPO5	57510	broad.mit.edu	37	chr6	43538730	43538730	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttccaaaatgttcaatgttCcctgaaaaagaacaagagat	17	10	6	8	0	1	3	1	1	0	2	3	4	3	3	2	0	1	2	2	0	7	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:43538730C>T	uc003ovp.2	-	4	513	c.302G>A	c.(301-303)GGA>GAA	p.G101E		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	101	Necessary for interaction with Ran.				gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			GTTCAATGTTCCCTGAAAAAG	0.408													5	127					0	0	0	0	T	43538730	T	T	43538730	3	4	116	1	0	0	0	0	1	0	0	0	17515	869	30	2	3428	2	XPO5	6	43538730	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	57568	43538730	127576337	133	20830											
TFAP2B	7021	broad.mit.edu	37	chr6	50803961	50803961	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcgccccctgaatgcctCaatgcatctctcctcggcgg	5	10	9	17	3	2	1	1	1	1	0	6	1	3	1	4	2	2	1	4	2	2	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:50803961C>T	uc003pag.2	+	4	955	c.789C>T	c.(787-789)CTC>CTT	p.L263L		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	263					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					CTGAATGCCTCAATGCATCTC	0.428													13	46					0	0	0	0	T	50803961	T	T	50803961	2	4	116	1	0	0	0	0	0	0	0	1	15854	813	29	2		2	TFAP2B	6	50803961	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	7265231	50803961	120311106	134	20831											
DST	667	broad.mit.edu	37	chr6	56437028	56437028	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagactatgcaaaacttcaaGatgtttcttgtgttctaaaa	14	14	7	6	0	3	2	1	0	2	2	3	3	3	2	0	0	2	3	0	0	6	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:56437028G>C	uc003pdf.2	-	47	7262	c.7234C>G	c.(7234-7236)CTT>GTT	p.L2412V	DST_uc003pcz.3_Missense_Mutation_p.L2234V|DST_uc011dxj.1_Missense_Mutation_p.L2263V|DST_uc011dxk.1_Missense_Mutation_p.L2274V|DST_uc003pcy.3_Missense_Mutation_p.L1908V|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4320					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AAAACTTCAAGATGTTTCTTG	0.333													5	11					0	0	0	0	C	56437028	C	C	56437028	3	2	116	1	0	0	0	0	1	0	0	0	4805	942	33	2	9997	2	DST	6	56437028	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5633067	56437028	114678039	135	20832											
ZNF451	26036	broad.mit.edu	37	chr6	57012646	57012646	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactgctaacaagccttcatCagctattactgttattgatc	11	14	6	10	0	2	1	2	1	0	0	3	2	2	1	1	0	5	3	1	0	5	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:57012646C>T	uc003pdm.1	+	10	1987	c.1763C>T	c.(1762-1764)TCA>TTA	p.S588L	ZNF451_uc003pdl.2_Missense_Mutation_p.S588L|ZNF451_uc003pdn.1_Missense_Mutation_p.S588L|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.S588L	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	588					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AAGCCTTCATCAGCTATTACT	0.393													15	62					0	0	0	0	T	57012646	T	T	57012646	3	4	116	1	0	0	0	0	1	0	0	0	17989	838	29	2	1801	2	ZNF451	6	57012646	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	575618	57012646	114102421	136	20833											
LMBRD1	55788	broad.mit.edu	37	chr6	70411789	70411789	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactgtacttactttgacaaGaagagagaaattacaaacag	18	10	7	6	0	0	4	0	1	0	3	0	5	0	4	0	0	5	1	0	0	8	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:70411789G>A	uc003pfa.2	-	10	1087	c.972C>T	c.(970-972)TTC>TTT	p.F324F	LMBRD1_uc003pey.2_Silent_p.F120F|LMBRD1_uc003pez.2_Silent_p.F251F|LMBRD1_uc010kal.2_Silent_p.F251F|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	324	Helical; Name=6; (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						ACTTTGACAAGAAGAGAGAAA	0.294													4	15					0	0	0	0	A	70411789	A	A	70411789	2	1	116	1	0	0	0	0	0	0	0	1	8884	933	33	2		2	LMBRD1	6	70411789	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	13399143	70411789	100703278	137	20834											
LMBRD1	55788	broad.mit.edu	37	chr6	70423682	70423682	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctggcaaaggtcgaccaTctttgctctgcaaataacag	11	11	9	10	1	2	0	0	0	2	0	3	1	2	0	1	2	4	4	1	2	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:70423682T>C	uc003pfa.2	-	9	885	c.770A>G	c.(769-771)GAT>GGT	p.D257G	LMBRD1_uc003pey.2_Missense_Mutation_p.D53G|LMBRD1_uc003pez.2_Missense_Mutation_p.D184G|LMBRD1_uc010kal.2_Missense_Mutation_p.D184G|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	257	Cytoplasmic (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						AGGTCGACCATCTTTGCTCTG	0.363													7	23					0	0	0	0	C	70423682	C	C	70423682	3	2	116	1	0	0	0	0	1	0	0	0	8884	1435	50	5	884	5	LMBRD1	6	70423682	Missense_Mutation	SNP	T	TCGA-CR-5248-01A-01D-2012-08	11893	70423682	100691385	138	20835											
BCKDHB	594	broad.mit.edu	37	chr6	81053418	81053418	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctagaggctcctatatcaaGagtatgtggttatgacacac	12	11	9	9	0	1	3	1	1	0	2	2	3	2	3	2	2	0	3	2	2	6	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:81053418G>C	uc003pjd.2	+	10	1143	c.1076G>C	c.(1075-1077)AGA>ACA	p.R359T	BCKDHB_uc003pje.2_Missense_Mutation_p.R359T	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta	359					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		CCTATATCAAGAGTATGTGGT	0.373													5	45					0	0	0	0	C	81053418	C	C	81053418	3	2	116	1	0	0	0	0	1	0	0	0	1362	942	33	2	1114	2	BCKDHB	6	81053418	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	10629736	81053418	90061649	139	20836											
MCM9	254394	broad.mit.edu	37	chr6	119252640	119252640	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acagcctcaggctgagaaagGgactggagaattgtcaaggc	13	6	14	8	0	2	2	2	1	0	2	2	5	2	3	1	4	1	1	1	4	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:119252640G>A	uc003pyh.2	-	2	512	c.249C>T	c.(247-249)TCC>TCT	p.S83S		NM_153255	NP_694987	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	83					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			ovary(1)	1		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		GCTGAGAAAGGGACTGGAGAA	0.423													7	28					0	0	0	0	A	119252640	A	A	119252640	2	1	116	1	0	0	0	0	0	0	0	1	9447	1219	43	4		4	MCM9	6	119252640	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	38199222	119252640	51862427	140	20837											
LAMA2	3908	broad.mit.edu	37	chr6	129687405	129687405	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gccttcttctcggtgacttgGctcgcctggagcagatggtc	4	12	13	12	2	2	2	0	1	2	1	5	3	2	3	2	4	1	2	2	4	0	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:129687405G>T	uc003qbn.2	+	33	4864	c.4759G>T	c.(4759-4761)GCT>TCT	p.A1587S	LAMA2_uc003qbo.2_Missense_Mutation_p.A1587S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1587	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CGGTGACTTGGCTCGCCTGGA	0.478													16	52					6.94344e-10	9.72415e-10	1	0	T	129687405	T	T	129687405	3	4	116	1	0	0	0	0	1	0	0	0	8646	1203	42	4	4889	4	LAMA2	6	129687405	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	10434765	129687405	41427662	141	20838											
MAP3K5	4217	broad.mit.edu	37	chr6	137019686	137019686	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgatccacaagaggtaagcaGatgggtccaagaagcagctc	14	5	12	10	1	0	3	0	0	0	3	3	4	2	3	2	2	3	4	2	2	4	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:137019686G>A	uc003qhc.2	-	4	1108	c.747C>T	c.(745-747)ATC>ATT	p.I249I	MAP3K5_uc011edk.1_Silent_p.I94I|MAP3K5_uc010kgw.1_Silent_p.I249I	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	249					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GAGGTAAGCAGATGGGTCCAA	0.413													6	23					0	0	0	0	A	137019686	A	A	137019686	2	1	116	1	0	0	0	0	0	0	0	1	9306	932	33	2		2	MAP3K5	6	137019686	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7332281	137019686	34095381	142	20839											
HIVEP2	3097	broad.mit.edu	37	chr6	143081778	143081778	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggacatgctatgcttctctgCtgctttgtgcaaatcttcca	7	15	8	11	0	2	0	0	0	2	0	4	1	3	1	1	1	5	5	1	1	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:143081778C>T	uc003qjd.2	-	9	6390	c.5647G>A	c.(5647-5649)GCA>ACA	p.A1883T		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1883					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TGCTTCTCTGCTGCTTTGTGC	0.294													4	14					0	0	0	0	T	143081778	T	T	143081778	3	4	116	1	0	0	0	0	1	0	0	0	7226	797	28	4	1701	4	HIVEP2	6	143081778	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	6062092	143081778	28033289	143	20840											
SASH1	23328	broad.mit.edu	37	chr6	148865685	148865685	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgaaaaggggcagccccGccagccccaccagccctagc	10	2	11	18	1	0	1	0	1	0	0	0	1	0	1	7	2	4	1	7	2	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:148865685G>A	uc003qme.1	+	18	3554	c.3079G>A	c.(3079-3081)GCC>ACC	p.A1027T	SASH1_uc011eeb.1_Missense_Mutation_p.A788T|SASH1_uc003qmf.1_Missense_Mutation_p.A437T	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	1027	Pro-rich.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GGGCAGCCCCGCCAGCCCCAC	0.701													5	37					0	0	0	0	A	148865685	A	A	148865685	3	1	116	1	0	0	0	0	1	0	0	0	13913	1087	38	1	3149	1	SASH1	6	148865685	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5783907	148865685	22249382	144	20841											
ZBTB2	57621	broad.mit.edu	37	chr6	151686993	151686993	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acacgtggcgggcagcctggTtggccctgcaaaagcttttg	7	9	14	11	2	0	0	0	0	0	0	0	0	0	0	2	4	3	4	2	4	2	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:151686993T>C	uc003qoh.2	-	3	1343	c.1208A>G	c.(1207-1209)AAC>AGC	p.N403S		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	403	C2H2-type 3; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		GGCAGCCTGGTTGGCCCTGCA	0.517													19	51					0	0	0	0	C	151686993	C	C	151686993	3	2	116	1	0	0	0	0	1	0	0	0	17595	1725	60	5	340	5	ZBTB2	6	151686993	Missense_Mutation	SNP	T	TCGA-CR-5248-01A-01D-2012-08	2821308	151686993	19428074	145	20842											
MLLT4	4301	broad.mit.edu	37	chr6	168226205	168226205	+	5'Flank	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgaagaattggcagataacGatgtgtctgagagaagaggc	14	7	15	5	2	1	5	0	1	1	4	1	8	1	5	0	2	1	1	0	2	4	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr6:168226205G>A	uc003qwd.2	+						MLLT4_uc003qwb.1_5'Flank|MLLT4_uc003qwc.1_5'Flank|C6orf124_uc003qwa.2_RNA	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia						adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GGCAGATAACGATGTGTCTGA	0.532			T	MLL	AL								4	11					0	0	0	0	A	168226205	A	A	168226205	1	1	116	0	1	0	0	0	0	0	0	0	9682	1073	37	1		1	MLLT4	6	168226205	5'Flank	SNP	G	TCGA-CR-5248-01A-01D-2012-08	16539212	168226205	2888862	146	20843											
WIPI2	26100	broad.mit.edu	37	chr7	5232766	5232766	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagagaagtgaaaggggcatCaagagcagctggtcttggcc	12	7	15	7	0	2	3	1	1	1	2	2	4	2	3	1	4	2	3	1	4	4	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:5232766C>G	uc003snv.2	+	2	308	c.92C>G	c.(91-93)TCA>TGA	p.S31*	WIPI2_uc003snw.2_Nonsense_Mutation_p.S31*|WIPI2_uc003snx.2_Intron|WIPI2_uc003sny.2_Intron|WIPI2_uc010ksv.2_Translation_Start_Site	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	31					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		AAAGGGGCATCAAGAGCAGCT	0.388													8	98					0	0	0	0	G	5232766	G	G	5232766	4	3	116	1	0	0	0	0	0	1	0	0	17439	838	29	2	98	2	WIPI2	7	5232766	Nonsense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		5232766	153905897	147	20844											
EIF2AK1	27102	broad.mit.edu	37	chr7	6086667	6086667	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttcctaagatggcaagttCttcaaattcatttaagtaac	13	16	5	7	0	3	1	2	0	1	1	4	1	4	1	1	1	1	3	1	1	5	9			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:6086667C>G	uc003spp.2	-	5	651	c.505G>C	c.(505-507)GAA>CAA	p.E169Q	EIF2AK1_uc003spq.2_Missense_Mutation_p.E169Q|EIF2AK1_uc011jwm.1_Missense_Mutation_p.E45Q|EIF2AK1_uc003spr.1_5'Flank	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	169	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		ATGGCAAGTTCTTCAAATTCA	0.348													7	23					0	0	0	0	G	6086667	G	G	6086667	3	3	116	1	0	0	0	0	1	0	0	0	5018	922	32	2	1431	2	EIF2AK1	7	6086667	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	853901	6086667	153051996	148	20845											
C7orf31	136895	broad.mit.edu	37	chr7	25218826	25218826	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagttgggcgagtaaccgtCtggagggggttgtgcaattc	7	10	17	7	2	1	0	0	0	1	0	2	2	1	1	1	4	2	5	1	4	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:25218826C>G	uc003sxn.1	-	2	663	c.102G>C	c.(100-102)CAG>CAC	p.Q34H		NM_138811	NP_620166	Q8N865	CG031_HUMAN	hypothetical protein LOC136895	34											0						GAGTAACCGTCTGGAGGGGGT	0.428													14	47					0	0	0	0	G	25218826	G	G	25218826	3	3	116	1	0	0	0	0	1	0	0	0	2398	912	32	2	1706	2	C7orf31	7	25218826	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	19132159	25218826	133919837	149	20846											
NFE2L3	9603	broad.mit.edu	37	chr7	26224729	26224729	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtaggtggctactacccaGaacccagtaagctttgtcac	10	10	9	12	0	1	1	1	0	0	1	1	1	1	1	2	2	4	4	2	2	5	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:26224729G>T	uc003sxq.2	+	4	1683	c.1411G>T	c.(1411-1413)GAA>TAA	p.E471*		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	471					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						CTACTACCCAGAACCCAGTAA	0.428													27	97					6.32553e-13	8.92297e-13	1	0	T	26224729	T	T	26224729	4	4	116	1	0	0	0	0	0	1	0	0	10423	943	33	2	1425	2	NFE2L3	7	26224729	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1005903	26224729	132913934	150	20847											
BMPER	168667	broad.mit.edu	37	chr7	34101656	34101656	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgctgtcctatttgcactGaaagtaagtttattcctttg	9	17	8	7	0	0	1	0	1	0	0	2	2	2	1	2	0	2	4	2	0	4	7	rs139550819		TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:34101656G>A	uc011kap.1	+	11	1189	c.1075G>A	c.(1075-1077)GAA>AAA	p.E359K		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	359					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						TATTTGCACTGAAAGTAAGTT	0.299													4	33					0	0	0	0	A	34101656	A	A	34101656	3	1	116	1	0	0	0	0	1	0	0	0	1471	1291	45	2	1117	2	BMPER	7	34101656	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7876927	34101656	125037007	151	20848											
AOAH	313	broad.mit.edu	37	chr7	36677476	36677476	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaatcggggacttcttgAcaatttgtcttgccttctgt	7	15	9	10	1	3	2	0	1	3	1	4	3	3	3	2	2	1	0	2	2	2	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:36677476A>T	uc003tfh.3	-	5	832	c.431T>A	c.(430-432)GTC>GAC	p.V144D	AOAH_uc010kxf.2_Missense_Mutation_p.V144D|AOAH_uc011kba.1_Missense_Mutation_p.V112D	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	144					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						GGACTTCTTGACAATTTGTCT	0.428													7	30					0	0	0	0	T	36677476	T	T	36677476	3	4	116	1	0	0	0	0	1	0	0	0	726	275	10	5	1705	5	AOAH	7	36677476	Missense_Mutation	SNP	A	TCGA-CR-5248-01A-01D-2012-08	2575820	36677476	122461187	152	20849											
ABCB4	5244	broad.mit.edu	37	chr7	87069132	87069132	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcagctgggcccctctctCtccaaccagggtgtcaaatt	8	10	8	15	0	4	0	2	0	2	0	6	0	4	0	4	2	2	1	4	2	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:87069132C>T	uc003uiv.1	-	14	1658	c.1582G>A	c.(1582-1584)GAG>AAG	p.E528K	ABCB4_uc003uiw.1_Missense_Mutation_p.E528K|ABCB4_uc003uix.1_Missense_Mutation_p.E528K	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	528	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GCCCCTCTCTCTCCAACCAGG	0.478													26	75					0	0	0	0	T	87069132	T	T	87069132	3	4	116	1	0	0	0	0	1	0	0	0	43	922	32	2	2338	2	ABCB4	7	87069132	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	50391656	87069132	72069531	153	20850											
ZNF804B	219578	broad.mit.edu	37	chr7	88956698	88956698	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgggaatttgctcgaaatgTagcttctaagtcatggaaag	13	11	11	6	2	2	0	1	0	1	0	3	3	2	2	0	2	2	3	0	2	5	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:88956698T>C	uc011khi.1	+	3	828	c.290T>C	c.(289-291)GTA>GCA	p.V97A		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	97						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GCTCGAAATGTAGCTTCTAAG	0.328										HNSCC(36;0.09)			7	50					0	0	0	0	C	88956698	C	C	88956698	3	2	116	1	0	0	0	0	1	0	0	0	18238	1638	57	5	300	5	ZNF804B	7	88956698	Missense_Mutation	SNP	T	TCGA-CR-5248-01A-01D-2012-08	1887566	88956698	70181965	154	20851											
MCM7	4176	broad.mit.edu	37	chr7	99696975	99696975	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agggtcccgactccgctgctCcatcattagccgatgctcaa	8	9	9	15	3	2	0	2	0	0	0	5	2	5	0	4	1	3	3	4	1	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:99696975C>T	uc003usw.1	-	4	838	c.328G>A	c.(328-330)GAG>AAG	p.E110K	MCM7_uc003usv.1_5'UTR|MCM7_uc003usx.1_5'UTR|AP4M1_uc011kjg.1_5'Flank|AP4M1_uc010lgl.1_5'Flank|AP4M1_uc003utb.3_5'Flank|AP4M1_uc003utc.3_5'Flank|AP4M1_uc010lgm.2_5'Flank|AP4M1_uc003utd.2_5'Flank|AP4M1_uc011kjh.1_5'Flank|AP4M1_uc003ute.3_5'Flank|AP4M1_uc003utf.3_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	110					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	CTCCGCTGCTCCATCATTAGC	0.483													23	100					0	0	0	0	T	99696975	T	T	99696975	3	4	116	1	0	0	0	0	1	0	0	0	9445	864	30	2	1879	2	MCM7	7	99696975	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	10740277	99696975	59441688	155	20852											
MUC17	140453	broad.mit.edu	37	chr7	100678577	100678577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacgctggtgaccagtcctGaggctagcacccttttaaca	9	9	9	14	1	0	2	0	2	0	0	1	2	1	2	4	2	2	3	4	2	2	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:100678577G>A	uc003uxp.1	+	3	3933	c.3880G>A	c.(3880-3882)GAG>AAG	p.E1294K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1294	Extracellular (Potential).|Ser-rich.|19.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GACCAGTCCTGAGGCTAGCAC	0.473													107	407					0	0	0	0	A	100678577	A	A	100678577	3	1	116	1	0	0	0	0	1	0	0	0	10027	1291	45	2	3890	2	MUC17	7	100678577	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	981602	100678577	58460086	156	20853											
RELN	5649	broad.mit.edu	37	chr7	103137182	103137182	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taacagaaatgtatttctggTaatccatctcatggagcaaa	15	12	7	7	0	2	1	1	0	2	1	4	2	3	2	1	2	2	3	1	2	5	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:103137182T>C	uc003vca.2	-	56	9144	c.8984A>G	c.(8983-8985)TAC>TGC	p.Y2995C	RELN_uc010liz.2_Missense_Mutation_p.Y2995C	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2995					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GTATTTCTGGTAATCCATCTC	0.418													12	47					0	0	0	0	C	103137182	C	C	103137182	3	2	116	1	0	0	0	0	1	0	0	0	13285	1638	57	5	1438	5	RELN	7	103137182	Missense_Mutation	SNP	T	TCGA-CR-5248-01A-01D-2012-08	2458605	103137182	56001481	157	20854											
TMEM168	64418	broad.mit.edu	37	chr7	112424433	112424433	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtggttagtaaagtgggccGatgacggacataaccagaaa	14	8	13	6	2	0	2	0	1	0	1	0	4	0	3	2	3	1	2	2	3	5	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:112424433G>A	uc003vgn.2	-	2	840	c.448C>T	c.(448-450)CGG>TGG	p.R150W	TMEM168_uc010lju.2_Missense_Mutation_p.R150W|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	150						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						AAAGTGGGCCGATGACGGACA	0.408													7	60					0	0	0	0	A	112424433	A	A	112424433	3	1	116	1	0	0	0	0	1	0	0	0	16149	1057	37	1	1661	1	TMEM168	7	112424433	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	9287251	112424433	46714230	158	20855											
CADPS2	93664	broad.mit.edu	37	chr7	121960236	121960236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atatcagccttcttcttcttCgtcactgtctttcatagtaa	8	18	4	11	1	7	0	3	0	4	0	8	0	7	0	1	0	1	1	1	0	3	8			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:121960236C>T	uc010lkp.2	-	29	4037	c.3874G>A	c.(3874-3876)GAA>AAA	p.E1292K	CADPS2_uc011knx.1_Missense_Mutation_p.E667K|CADPS2_uc003vkg.3_Missense_Mutation_p.E946K|CADPS2_uc010lkq.2_Missense_Mutation_p.E1251K	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	1292					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						TCTTCTTCTTCGTCACTGTCT	0.413													20	78					0	0	0	0	T	121960236	T	T	121960236	3	4	116	1	0	0	0	0	1	0	0	0	2583	893	31	1	20	1	CADPS2	7	121960236	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	9535803	121960236	37178427	159	20856											
GCC1	79571	broad.mit.edu	37	chr7	127222320	127222320	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcctcacgatgccgttcGccctcctccagcagccgatc	6	8	7	20	4	1	0	1	0	0	0	6	2	4	0	7	0	3	2	7	0	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:127222320G>A	uc003vma.2	-	2	2494	c.2076C>T	c.(2074-2076)GGC>GGT	p.G692G		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	692	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						GATGCCGTTCGCCCTCCTCCA	0.582													18	58					0	0	0	0	A	127222320	A	A	127222320	2	1	116	1	0	0	0	0	0	0	0	1	6320	1074	38	1		1	GCC1	7	127222320	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5262084	127222320	31916343	160	20857											
FLNC	2318	broad.mit.edu	37	chr7	128485033	128485033	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagcgcggcaaggtcggtGaggcagccaccttcactgtg	7	7	16	11	3	1	1	1	1	0	0	2	2	1	2	2	5	2	2	2	5	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:128485033G>A	uc003vnz.3	+	21	3723	c.3514G>A	c.(3514-3516)GAG>AAG	p.E1172K	FLNC_uc003voa.3_Missense_Mutation_p.E1172K	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1172	Filamin 10.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CAAGGTCGGTGAGGCAGCCAC	0.652													13	35					0	0	0	0	A	128485033	A	A	128485033	3	1	116	1	0	0	0	0	1	0	0	0	5967	1291	45	2	3596	2	FLNC	7	128485033	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1262713	128485033	30653630	161	20858											
STRA8	346673	broad.mit.edu	37	chr7	134916760	134916760	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgatgtggacaagatcctCtttttcaatcaagaaatcag	14	13	7	7	0	4	3	3	1	1	2	5	4	5	4	1	1	0	0	1	1	4	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:134916760C>G	uc011kpx.1	+	1	30	c.30C>G	c.(28-30)CTC>CTG	p.L10L		NM_182489	NP_872295	Q7Z7C7	STRA8_HUMAN	STRA8	10					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0						ACAAGATCCTCTTTTTCAATC	0.488													16	71					0	0	0	0	G	134916760	G	G	134916760	2	3	116	1	0	0	0	0	0	0	0	1	15389	900	32	2		2	STRA8	7	134916760	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	6431727	134916760	24221903	162	20859											
TRYX3	136541	broad.mit.edu	37	chr7	141952098	141952098	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtaaaaaattttggcataGatgccaacatcggctctcaa	15	11	7	8	1	1	1	1	0	1	1	3	1	1	1	1	2	2	3	1	2	7	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:141952098G>T	uc003vxb.2	-	5	989	c.669C>A	c.(667-669)ATC>ATA	p.I223I	TRYX3_uc003vxc.3_Silent_p.I223I	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	223	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					TTTTGGCATAGATGCCAACAT	0.458													7	19					0.00198382	0.00265114	1	0	T	141952098	T	T	141952098	2	4	116	1	0	0	0	0	0	0	0	1	16671	932	33	2		2	TRYX3	7	141952098	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7035338	141952098	17186565	163	20860											
TPK1	27010	broad.mit.edu	37	chr7	144245667	144245667	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacaccaatcaccctccattCcagtgtctacatgcaacctg	11	9	4	17	0	2	0	1	0	1	0	4	0	4	0	5	0	3	1	5	0	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:144245667C>T	uc003weq.2	-	8	633	c.530G>A	c.(529-531)GGA>GAA	p.G177E	TPK1_uc003weo.2_Missense_Mutation_p.G123E|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Missense_Mutation_p.G128E|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	177					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	ACCCTCCATTCCAGTGTCTAC	0.468													19	60					0	0	0	0	T	144245667	T	T	144245667	3	4	116	1	0	0	0	0	1	0	0	0	16471	855	30	2	209	2	TPK1	7	144245667	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2293569	144245667	14892996	164	20861											
ABCF2	10061	broad.mit.edu	37	chr7	150920888	150920888	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catctctgccttgtcggcatCcagctcctccaggcgctcgt	4	11	9	17	3	1	0	0	0	1	0	7	0	4	0	4	2	2	3	4	2	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:150920888C>T	uc003wjp.2	-	5	709	c.598G>A	c.(598-600)GAT>AAT	p.D200N	ABCF2_uc003wjo.1_Missense_Mutation_p.D200N	NM_007189	NP_009120	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F, member 2	200	ABC transporter 1.					ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTGTCGGCATCCAGCTCCTCC	0.602													10	14					0	0	0	0	T	150920888	T	T	150920888	3	4	116	1	0	0	0	0	1	0	0	0	66	855	30	2	1358	2	ABCF2	7	150920888	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	6675221	150920888	8217775	165	20862											
GALNTL5	168391	broad.mit.edu	37	chr7	151716792	151716792	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacggaaatattcgcgagcGtgttgagttaaggaaacgac	13	9	12	7	5	0	1	0	1	0	0	1	5	0	3	0	2	3	2	0	2	5	5	rs149825214	byFrequency	TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr7:151716792G>A	uc003wkp.2	+	9	1461	c.1238G>A	c.(1237-1239)CGT>CAT	p.R413H	GALNTL5_uc003wkq.2_Missense_Mutation_p.R164H|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.R302H	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	413	Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		ATTCGCGAGCGTGTTGAGTTA	0.423													6	53					0	0	0	0	A	151716792	A	A	151716792	3	1	116	1	0	0	0	0	1	0	0	0	6259	1145	40	1	1268	1	GALNTL5	7	151716792	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	795904	151716792	7421871	166	20863											
C8orf42	157695	broad.mit.edu	37	chr8	444518	444518	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggacttgggagatttacatCtttccaggagatgctgctca	9	13	11	8	0	2	2	1	0	1	2	3	5	3	3	1	3	3	2	1	3	1	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:444518C>G	uc003wpd.2	-	2	762	c.188G>C	c.(187-189)AGA>ACA	p.R63T	C8orf42_uc011kwg.1_Missense_Mutation_p.R63T	NM_175075	NP_778250	Q86YL5	CH042_HUMAN	hypothetical protein LOC157695	63											0		Ovarian(12;0.0481)|Colorectal(14;0.0815)|Hepatocellular(245;0.0968)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;5.16e-14)|OV - Ovarian serous cystadenocarcinoma(5;7.35e-07)|BRCA - Breast invasive adenocarcinoma(11;4.17e-06)|COAD - Colon adenocarcinoma(149;0.0255)		AGATTTACATCTTTCCAGGAG	0.398													5	47					0	0	0	0	G	444518	G	G	444518	3	3	116	1	0	0	0	0	1	0	0	0	2440	913	32	2	377	2	C8orf42	8	444518	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		444518	145919504	167	20864											
MTUS1	57509	broad.mit.edu	37	chr8	17532707	17532707	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcttacctagctctccccGgaggttaacaagttcttgag	8	12	9	12	1	3	1	0	1	3	0	4	2	3	2	3	2	3	4	3	2	4	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:17532707G>A	uc003wxv.2	-	8	3367	c.2893C>T	c.(2893-2895)CGG>TGG	p.R965W	MTUS1_uc003wxt.2_Missense_Mutation_p.R212W|MTUS1_uc011kyg.1_Missense_Mutation_p.R110W|MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.R911W|MTUS1_uc003wxs.2_Missense_Mutation_p.R131W	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	965	Potential.					Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		AGCTCTCCCCGGAGGTTAACA	0.463													10	42					0	0	0	0	A	17532707	A	A	17532707	3	1	116	1	0	0	0	0	1	0	0	0	10018	1115	39	1	951	1	MTUS1	8	17532707	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	17088189	17532707	128831315	168	20865											
CSGALNACT1	55790	broad.mit.edu	37	chr8	19363042	19363042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagacccaggccagcagcatCgctggcttggtactgcccat	8	7	11	15	1	0	1	0	0	0	1	1	1	0	1	3	3	4	5	3	3	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:19363042C>T	uc011kyn.1	-	4	1368	c.304G>A	c.(304-306)GAT>AAT	p.D102N	CSGALNACT1_uc011kyo.1_Missense_Mutation_p.D102N|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Missense_Mutation_p.D101N|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	102	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		CCAGCAGCATCGCTGGCTTGG	0.627													20	42					0	0	0	0	T	19363042	T	T	19363042	3	4	116	1	0	0	0	0	1	0	0	0	3955	884	31	1	1322	1	CSGALNACT1	8	19363042	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1830335	19363042	127000980	169	20866											
ATP6V1B2	526	broad.mit.edu	37	chr8	20074737	20074737	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcattctacccaagatttatCcacctatcaatgtgctgccc	10	13	4	14	0	3	1	2	0	1	1	4	1	4	1	4	0	3	1	4	0	5	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:20074737C>A	uc003wzp.2	+	12	1382	c.1168C>A	c.(1168-1170)CCA>ACA	p.P390T	ATP6V1B2_uc003wzq.1_5'Flank	NM_001693	NP_001684	P21281	VATB2_HUMAN	vacuolar H+ATPase B2	390					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		CAAGATTTATCCACCTATCAA	0.363													13	79					1.5842e-08	2.20279e-08	1	0	A	20074737	A	A	20074737	3	1	116	1	0	0	0	0	1	0	0	0	1181	855	30	2	1214	2	ATP6V1B2	8	20074737	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	711695	20074737	126289285	170	20867											
C8orf41	80185	broad.mit.edu	37	chr8	33357860	33357860	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttacctttacccgtccttGagaacagcggtccaggagaa	10	9	9	13	2	0	2	0	1	0	2	2	4	2	2	5	2	4	0	5	2	4	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:33357860G>A	uc003xjl.3	-	6	1933	c.1408C>T	c.(1408-1410)CAA>TAA	p.Q470*	C8orf41_uc010lvu.1_RNA|MAK16_uc003xjj.2_3'UTR|C8orf41_uc003xjk.3_Nonsense_Mutation_p.Q439*|C8orf41_uc010lvv.2_Intron|C8orf41_uc003xjm.3_Nonsense_Mutation_p.Q470*	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	470							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		ACCCGTCCTTGAGAACAGCGG	0.458													10	41					0	0	0	0	A	33357860	A	A	33357860	4	1	116	1	0	0	0	0	0	1	0	0	2439	1299	45	2	126	2	C8orf41	8	33357860	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	13283123	33357860	113006162	171	20868											
HGSNAT	138050	broad.mit.edu	37	chr8	43053070	43053070	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtggatgtgaaggggctgtgGacaggaaccccattctttta	9	11	14	7	0	1	1	0	1	1	0	1	4	1	4	2	5	1	1	2	5	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:43053070G>A	uc003xpx.3	+	17	1749	c.1701G>A	c.(1699-1701)TGG>TGA	p.W567*		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	595	Helical; (Potential).				lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			AGGGGCTGTGGACAGGAACCC	0.552													6	22					0	0	0	0	A	43053070	A	A	43053070	4	1	116	1	0	0	0	0	0	1	0	0	7127	1183	41	2	1767	2	HGSNAT	8	43053070	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	9695210	43053070	103310952	172	20869											
RP1	6101	broad.mit.edu	37	chr8	55539467	55539467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aagatctccatgagacacagGttggatctctgaatgatgct	12	11	10	8	0	2	4	0	3	2	2	4	6	2	5	1	2	1	2	1	2	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:55539467G>A	uc003xsd.1	+	4	3173	c.3025G>A	c.(3025-3027)GTT>ATT	p.V1009I	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1009					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGAGACACAGGTTGGATCTCT	0.383													44	193					0	0	0	0	A	55539467	A	A	55539467	3	1	116	1	0	0	0	0	1	0	0	0	13597	1261	44	4	3035	4	RP1	8	55539467	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	12486397	55539467	90824555	173	20870											
CYP7B1	9420	broad.mit.edu	37	chr8	65517375	65517375	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacaaaacgaatggtggttGaatatgaggacagtcgtaaa	17	8	11	5	2	0	2	0	2	0	0	1	4	0	3	0	3	2	2	0	3	8	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:65517375G>C	uc003xvj.2	-	5	1301	c.1097C>G	c.(1096-1098)TCA>TGA	p.S366*		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	366					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				AATGGTGGTTGAATATGAGGA	0.443													25	36					0	0	0	0	C	65517375	C	C	65517375	4	2	116	1	0	0	0	0	0	1	0	0	4214	1294	45	2	431	2	CYP7B1	8	65517375	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	9977908	65517375	80846647	174	20871											
GEM	2669	broad.mit.edu	37	chr8	95272531	95272531	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgttccctgactcagaggaGatgactgagtctgtggagtc	8	11	14	8	0	2	5	1	3	1	2	4	7	3	6	1	2	0	1	1	2	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:95272531G>C	uc003ygj.2	-	2	450	c.201C>G	c.(199-201)ATC>ATG	p.I67M	GEM_uc003ygi.2_Missense_Mutation_p.I67M	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein	67					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			ACTCAGAGGAGATGACTGAGT	0.587													11	53					0	0	0	0	C	95272531	C	C	95272531	3	2	116	1	0	0	0	0	1	0	0	0	6366	932	33	2	705	2	GEM	8	95272531	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	29755156	95272531	51091491	175	20872											
RNF19A	25897	broad.mit.edu	37	chr8	101287254	101287254	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacgtaagctctgggctctCtcttgtcgagcagcatcaca	10	10	9	12	2	4	0	1	0	3	0	6	1	4	0	0	1	4	5	0	1	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:101287254C>G	uc003yjj.1	-	4	1127	c.810G>C	c.(808-810)GAG>GAC	p.E270D	RNF19A_uc003yjk.1_Missense_Mutation_p.E270D	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	270					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			TCTGGGCTCTCTCTTGTCGAG	0.428													10	69					0	0	0	0	G	101287254	G	G	101287254	3	3	116	1	0	0	0	0	1	0	0	0	13535	912	32	2	1738	2	RNF19A	8	101287254	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	6014723	101287254	45076768	176	20873											
EPPK1	83481	broad.mit.edu	37	chr8	144942096	144942096	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagttctggattgcaacaCgtgtctcgtggcctcattga	7	13	11	10	2	3	1	1	1	2	0	4	2	3	2	1	2	3	3	1	2	1	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:144942096C>T	uc003zaa.1	-	1	5339	c.5326G>A	c.(5326-5328)GTG>ATG	p.V1776M		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1776						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GATTGCAACACGTGTCTCGTG	0.527													6	65					0	0	0	0	T	144942096	T	T	144942096	3	4	116	1	0	0	0	0	1	0	0	0	5214	536	19	1	1940	1	EPPK1	8	144942096	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	43654842	144942096	1421926	177	20874											
CPSF1	29894	broad.mit.edu	37	chr8	145623786	145623786	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accgtggggccctgagtggcGaagccactggtgtccagctc	6	7	15	13	2	0	1	0	1	0	0	2	2	1	1	4	4	2	1	4	4	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr8:145623786G>A	uc003zcj.2	-	19	1875	c.1800C>T	c.(1798-1800)TTC>TTT	p.F600F		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	600					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCTGAGTGGCGAAGCCACTGG	0.657													6	181					0	0	0	0	A	145623786	A	A	145623786	2	1	116	1	0	0	0	0	0	0	0	1	3839	1049	37	1		1	CPSF1	8	145623786	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	681690	145623786	740236	178	20875											
DOCK8	81704	broad.mit.edu	37	chr9	368027	368027	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttttccagaaaccttctCtatgtctacccacagaggct	9	14	5	13	0	3	2	0	0	3	2	5	2	4	2	3	1	2	1	3	1	3	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:368027C>G	uc003zgf.2	+	15	1801	c.1689C>G	c.(1687-1689)CTC>CTG	p.L563L	DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Silent_p.L495L|DOCK8_uc010mgw.1_5'UTR|DOCK8_uc003zgk.2_5'UTR|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	563	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GAAACCTTCTCTATGTCTACC	0.378													9	56					0	0	0	0	G	368027	G	G	368027	2	3	116	1	0	0	0	0	0	0	0	1	4715	900	32	2		2	DOCK8	9	368027	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08		368027	140845404	179	20876											
VLDLR	7436	broad.mit.edu	37	chr9	2645067	2645067	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatggatcttgctactggcGtgtgcaaggcagtaggtaaa	12	10	13	6	1	1	0	0	0	1	0	1	1	1	1	0	4	3	5	0	4	6	4	rs140062795	byFrequency	TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:2645067G>A	uc003zhk.1	+	9	1694	c.1297G>A	c.(1297-1299)GTG>ATG	p.V433M	VLDLR_uc003zhl.1_Missense_Mutation_p.V433M|VLDLR_uc003zhm.1_RNA|VLDLR_uc003zhn.1_Missense_Mutation_p.V392M	NM_003383	NP_003374	P98155	VLDLR_HUMAN	very low density lipoprotein receptor isoform a	433	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		TGCTACTGGCGTGTGCAAGGC	0.418													6	108					0	0	0	0	A	2645067	A	A	2645067	3	1	116	1	0	0	0	0	1	0	0	0	17242	1145	40	1	1331	1	VLDLR	9	2645067	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2277040	2645067	138568364	180	20877											
KIAA2026	158358	broad.mit.edu	37	chr9	5922659	5922659	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttttccttctttatgctGaatcacaaaattcttaggca	10	17	5	9	0	3	1	1	1	2	0	4	1	4	1	1	1	2	3	1	1	5	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:5922659G>A	uc003zjq.3	-	8	3553	c.3337C>T	c.(3337-3339)CAG>TAG	p.Q1113*	KIAA2026_uc010mht.2_Nonsense_Mutation_p.Q288*	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1113										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TCTTTATGCTGAATCACAAAA	0.373													27	100					0	0	0	0	A	5922659	A	A	5922659	4	1	116	1	0	0	0	0	0	1	0	0	8309	1299	45	2	2978	2	KIAA2026	9	5922659	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3277592	5922659	135290772	181	20878											
TESK1	7016	broad.mit.edu	37	chr9	35605991	35605991	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgcccccaggttcggcaccGacagtcagggcaagtcatgg	8	6	13	14	2	2	0	2	0	0	0	3	1	2	0	3	4	1	3	3	4	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:35605991G>C	uc003zxa.2	+	2	566	c.230G>C	c.(229-231)CGA>CCA	p.R77P	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_5'UTR	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	77	Protein kinase.				cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GTTCGGCACCGACAGTCAGGG	0.672													5	71					0	0	0	0	C	35605991	C	C	35605991	3	2	116	1	0	0	0	0	1	0	0	0	15833	1058	37	3	236	3	TESK1	9	35605991	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	29683332	35605991	105607440	182	20879											
TESK1	7016	broad.mit.edu	37	chr9	35606017	35606017	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggcaagtcatggtgctgAagatgaacaagctccccagt	12	7	12	10	0	1	3	1	2	0	1	2	3	2	3	2	2	3	3	2	2	4	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:35606017A>C	uc003zxa.2	+	2	592	c.256A>C	c.(256-258)AAG>CAG	p.K86Q	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_5'UTR	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	86	Protein kinase.	ATP (By similarity).			cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CATGGTGCTGAAGATGAACAA	0.657													5	70					0	0	0	0	C	35606017	C	C	35606017	3	2	116	1	0	0	0	0	1	0	0	0	15833	247	9	5	262	5	TESK1	9	35606017	Missense_Mutation	SNP	A	TCGA-CR-5248-01A-01D-2012-08	26	35606017	105607414	183	20880											
FBXO10	26267	broad.mit.edu	37	chr9	37531963	37531963	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccagcctctgcattgtggtaAatgttgttgccggcaatcaa	9	12	10	10	1	2	0	1	0	1	0	2	0	2	0	3	2	3	5	3	2	4	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:37531963A>C	uc004aab.2	-	4	1561	c.1512T>G	c.(1510-1512)ATT>ATG	p.I504M	FBXO10_uc004aac.2_Missense_Mutation_p.I520M|FBXO10_uc004aad.2_Missense_Mutation_p.I54M	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	504	PbH1 6.					ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		CATTGTGGTAAATGTTGTTGC	0.502													15	45					0	0	0	0	C	37531963	C	C	37531963	3	2	116	1	0	0	0	0	1	0	0	0	5758	10	1	5	1390	5	FBXO10	9	37531963	Missense_Mutation	SNP	A	TCGA-CR-5248-01A-01D-2012-08	1925946	37531963	103681468	184	20881											
TMC1	117531	broad.mit.edu	37	chr9	75441857	75441857	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaagctggatggcgaagatCttgagacagctttcaaaccc	12	8	10	11	1	2	2	1	1	1	2	2	5	2	3	2	2	3	2	2	2	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:75441857C>G	uc004aiz.1	+	21	2616	c.2076C>G	c.(2074-2076)ATC>ATG	p.I692M	TMC1_uc010moz.1_Missense_Mutation_p.I650M|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.I546M|TMC1_uc010mpa.1_Missense_Mutation_p.I546M	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	692	Extracellular (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						TGGCGAAGATCTTGAGACAGC	0.463													47	151					0	0	0	0	G	75441857	G	G	75441857	3	3	116	1	0	0	0	0	1	0	0	0	16050	903	32	2	2142	2	TMC1	9	75441857	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	37909894	75441857	65771574	185	20882											
FLJ46321	389763	broad.mit.edu	37	chr9	84607429	84607429	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagattttccactcagctctGaggtaaggaagaaactagag	14	9	11	7	0	2	4	1	1	1	3	3	6	3	5	1	2	2	2	1	2	4	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:84607429G>A	uc004amn.2	+	4	2091	c.2044G>A	c.(2044-2046)GAG>AAG	p.E682K		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	682						integral to membrane					0						ACTCAGCTCTGAGGTAAGGAA	0.507													15	85					0	0	0	0	A	84607429	A	A	84607429	3	1	116	1	0	0	0	0	1	0	0	0	5964	1291	45	2	2058	2	FLJ46321	9	84607429	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	9165572	84607429	56606002	186	20883											
AGTPBP1	23287	broad.mit.edu	37	chr9	88247624	88247624	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataggctctttgaatggaggCggaatgtgaccaaaataatc	14	10	11	6	1	1	2	0	2	1	0	2	4	1	4	1	4	0	1	1	4	6	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:88247624C>T	uc011ltd.1	-	13	2001	c.1968G>A	c.(1966-1968)CCG>CCA	p.P656P	AGTPBP1_uc004aod.3_Silent_p.P282P|AGTPBP1_uc011ltc.1_Silent_p.P554P|AGTPBP1_uc010mqc.2_Silent_p.P616P|AGTPBP1_uc011lte.1_Silent_p.P668P	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	656					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						TGAATGGAGGCGGAATGTGAC	0.403													11	56					0	0	0	0	T	88247624	T	T	88247624	2	4	116	1	0	0	0	0	0	0	0	1	400	755	27	1		1	AGTPBP1	9	88247624	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3640195	88247624	52965807	187	20884											
FAM75C1	441452	broad.mit.edu	37	chr9	90537484	90537484	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgctgttgtgctccttccaGatgggcaagcatctgttgtg	5	13	12	11	1	1	1	0	0	1	1	3	1	3	1	3	1	2	6	3	1	1	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:90537484G>C	uc010mqi.2	+	4	2691	c.2662G>C	c.(2662-2664)GAT>CAT	p.D888H	FAM75C1_uc004apq.3_Missense_Mutation_p.D871H	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GCTCCTTCCAGATGGGCAAGC	0.552													6	157					0	0	0	0	C	90537484	C	C	90537484	3	2	116	1	0	0	0	0	1	0	0	0	5655	942	33	2	2676	2	FAM75C1	9	90537484	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2289860	90537484	50675947	188	20885											
WDR31	114987	broad.mit.edu	37	chr9	116079162	116079162	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagaagtcaagggtcctgatCcatccagagacaaggtgaaa	15	6	12	8	0	1	4	1	2	0	2	4	6	4	4	3	2	0	0	3	2	4	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:116079162C>G	uc004bhe.2	-	11	1223	c.971G>C	c.(970-972)GGA>GCA	p.G324A	uc004bhb.2_5'Flank|WDR31_uc004bhc.2_Missense_Mutation_p.G323A|WDR31_uc004bhd.2_Missense_Mutation_p.G199A|WDR31_uc004bhf.2_RNA	NM_001012361	NP_001012361	Q8NA23	WDR31_HUMAN	WD repeat domain 31 isoform 1	324											0						GGGTCCTGATCCATCCAGAGA	0.483													17	32					0	0	0	0	G	116079162	G	G	116079162	3	3	116	1	0	0	0	0	1	0	0	0	17354	855	30	2	136	2	WDR31	9	116079162	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	25541678	116079162	25134269	189	20886											
ZNF618	114991	broad.mit.edu	37	chr9	116812166	116812166	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgccgtcgagaaccccGcagctcaggaagatgatcgg	9	6	13	13	4	1	3	1	1	0	2	3	5	1	4	3	2	4	3	3	2	2	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:116812166G>A	uc004bid.2	+	15	2683	c.2584G>A	c.(2584-2586)GCA>ACA	p.A862T	ZNF618_uc004bic.2_Missense_Mutation_p.A769T|ZNF618_uc011lxi.1_Missense_Mutation_p.A829T|ZNF618_uc011lxj.1_Missense_Mutation_p.A830T|ZNF618_uc010mvb.2_Missense_Mutation_p.A452T	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	862					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGAGAACCCCGCAGCTCAGGA	0.597													6	108					0	0	0	0	A	116812166	A	A	116812166	3	1	116	1	0	0	0	0	1	0	0	0	18109	1087	38	1	2359	1	ZNF618	9	116812166	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	733004	116812166	24401265	190	20887											
LRSAM1	90678	broad.mit.edu	37	chr9	130263293	130263293	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtctggtccccacagagctGaaaccaccaatgggtgaggt	10	8	12	11	0	1	3	0	2	1	1	2	3	2	3	4	3	2	1	4	3	2	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:130263293G>A	uc004brb.1	+	25	2262	c.1917G>A	c.(1915-1917)CTG>CTA	p.L639L	LRSAM1_uc010mxk.1_Silent_p.L612L|LRSAM1_uc004brc.1_Silent_p.L639L|LRSAM1_uc004brd.1_Silent_p.L639L|LRSAM1_uc004bre.1_Silent_p.L219L|LRSAM1_uc004brg.1_Silent_p.L70L	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	639					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						CCACAGAGCTGAAACCACCAA	0.647													20	71					0	0	0	0	A	130263293	A	A	130263293	2	1	116	1	0	0	0	0	0	0	0	1	9093	1277	45	2		2	LRSAM1	9	130263293	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	13451127	130263293	10950138	191	20888											
FAM129B	64855	broad.mit.edu	37	chr9	130270171	130270171	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggatgtccttcatgacggtCtgcagcaccacctcctcgta	8	10	9	14	2	2	1	1	1	1	0	5	2	4	2	4	2	2	3	4	2	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:130270171C>G	uc004brh.2	-	13	1831	c.1629G>C	c.(1627-1629)CAG>CAC	p.Q543H	FAM129B_uc004bri.2_Missense_Mutation_p.Q530H|FAM129B_uc004brj.3_3'UTR	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	543							protein binding				0						TCATGACGGTCTGCAGCACCA	0.642													13	95					0	0	0	0	G	130270171	G	G	130270171	3	3	116	1	0	0	0	0	1	0	0	0	5465	912	32	2	619	2	FAM129B	9	130270171	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	6878	130270171	10943260	192	20889											
C9orf96	169436	broad.mit.edu	37	chr9	136260786	136260786	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccaggcagcctgaaggcCgtcctgaagacaatggagga	12	4	14	11	1	0	3	0	2	0	1	1	5	1	5	4	4	2	1	4	4	3	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr9:136260786C>A	uc004cdk.2	+	9	823	c.762C>A	c.(760-762)GCC>GCA	p.A254A	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	254	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GCCTGAAGGCCGTCCTGAAGA	0.557													29	66					3.65163e-15	5.20134e-15	1	0	A	136260786	A	A	136260786	2	1	116	1	0	0	0	0	0	0	0	1	2520	639	23	3		3	C9orf96	9	136260786	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	5990615	136260786	4952645	193	20890											
FRMD4A	55691	broad.mit.edu	37	chr10	13698869	13698869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgccctcgcggcccagcgacGgagtccgcaggatctgcgat	6	5	14	16	7	1	0	0	0	1	0	3	4	2	2	3	3	2	1	3	3	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:13698869G>A	uc001ims.2	-	22	3072	c.2720C>T	c.(2719-2721)CCG>CTG	p.P907L	FRMD4A_uc009xjf.1_Missense_Mutation_p.P907L	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	907						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GCCCAGCGACGGAGTCCGCAG	0.751													6	10					0	0	0	0	A	13698869	A	A	13698869	3	1	116	1	0	0	0	0	1	0	0	0	6085	1116	39	1	411	1	FRMD4A	10	13698869	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08		13698869	121835878	194	20891											
MARCH8	220972	broad.mit.edu	37	chr10	45956749	45956749	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctcgcagcagcgcgtgtcgGagctcttgatccactgctgc	5	9	13	14	4	1	1	0	1	1	0	4	2	2	2	1	1	5	5	1	1	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:45956749G>A	uc001jci.1	-	5	592	c.353C>T	c.(352-354)TCC>TTC	p.S118F	MARCH8_uc001jch.2_Missense_Mutation_p.S400F|MARCH8_uc001jcj.1_Missense_Mutation_p.S118F|MARCH8_uc001jck.1_Missense_Mutation_p.S118F|MARCH8_uc001jcg.1_5'UTR	NM_001002266	NP_001002266	Q5T0T0	MARH8_HUMAN	cellular modulator of immune recognition isoform	118	RING-CH-type.					cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding				0						GCGCGTGTCGGAGCTCTTGAT	0.572													5	45					0	0	0	0	A	45956749	A	A	45956749	3	1	116	1	0	0	0	0	1	0	0	0	9360	1174	41	2	534	2	MARCH8	10	45956749	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	32257880	45956749	89577998	195	20892											
NDST2	8509	broad.mit.edu	37	chr10	75567373	75567373	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtgggaagccgggcccgAcgaagaactggtcctggcac	10	4	15	12	3	0	1	0	0	0	1	1	4	1	2	3	4	2	1	3	4	3	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:75567373A>G	uc001jvk.2	-	3	1578	c.774T>C	c.(772-774)CGT>CGC	p.R258R	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Silent_p.R135R|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_Silent_p.R135R	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	258	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					GCCGGGCCCGACGAAGAACTG	0.557													8	36					0	0	0	0	G	75567373	G	G	75567373	2	3	116	1	0	0	0	0	0	0	0	1	10310	262	10	5		5	NDST2	10	75567373	Silent	SNP	A	TCGA-CR-5248-01A-01D-2012-08	29610624	75567373	59967374	196	20893											
CAMK2G	818	broad.mit.edu	37	chr10	75608802	75608802	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgctgctctccctgtacttcGatggctaggccaaaatcagc	8	11	9	13	1	2	0	1	0	1	0	4	1	2	0	2	2	4	4	2	2	4	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:75608802G>C	uc001jvv.1	-	7	586	c.462C>G	c.(460-462)ATC>ATG	p.I154M	CAMK2G_uc001jvm.1_Missense_Mutation_p.I162M|CAMK2G_uc001jvo.1_Missense_Mutation_p.I162M|CAMK2G_uc001jvq.1_Missense_Mutation_p.I162M|CAMK2G_uc001jvr.1_Missense_Mutation_p.I162M|CAMK2G_uc001jvp.1_Missense_Mutation_p.I162M|CAMK2G_uc001jvs.1_Missense_Mutation_p.I162M|CAMK2G_uc001jvt.1_RNA|CAMK2G_uc001jvu.1_Missense_Mutation_p.I140M|CAMK2G_uc010qkv.1_Intron	NM_172171	NP_751911	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II	162	Protein kinase.				insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)					CCTGTACTTCGATGGCTAGGC	0.562											OREG0020267	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	111					0	0	0	0	C	75608802	C	C	75608802	3	2	116	1	0	0	0	0	1	0	0	0	2614	1048	37	3	1344	3	CAMK2G	10	75608802	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	41429	75608802	59925945	197	20894											
ZMIZ1	57178	broad.mit.edu	37	chr10	81063878	81063878	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtctctgaagtgccccatCacattccggcgcatccagct	7	10	9	15	2	2	1	1	1	1	0	5	1	4	1	4	1	2	2	4	1	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:81063878C>T	uc001kaf.2	+	19	2804	c.2232C>T	c.(2230-2232)ATC>ATT	p.I744I	ZMIZ1_uc001kag.2_Silent_p.I620I|ZMIZ1_uc010qlq.1_5'Flank	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	744	SP-RING-type.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AGTGCCCCATCACATTCCGGC	0.612													10	33					0	0	0	0	T	81063878	T	T	81063878	2	4	116	1	0	0	0	0	0	0	0	1	17763	816	29	2		2	ZMIZ1	10	81063878	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	5455076	81063878	54470869	198	20895											
PLCE1	51196	broad.mit.edu	37	chr10	96005912	96005912	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaccaggacacacacctctCtgcccgctgcttcctccagc	7	7	7	20	2	1	0	0	0	1	0	4	2	3	1	5	1	3	2	5	1	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:96005912C>G	uc001kjk.2	+	8	3264	c.2630C>G	c.(2629-2631)TCT>TGT	p.S877C	PLCE1_uc010qnx.1_Missense_Mutation_p.S877C|PLCE1_uc001kjm.2_Missense_Mutation_p.S569C	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	877					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				ACACACCTCTCTGCCCGCTGC	0.582													3	49					0	0	0	0	G	96005912	G	G	96005912	3	3	116	1	0	0	0	0	1	0	0	0	12089	913	32	2	2942	2	PLCE1	10	96005912	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	14942034	96005912	39528835	199	20896											
NOC3L	64318	broad.mit.edu	37	chr10	96109029	96109029	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggcctaacttcgtaatttCtgcccttcacaaaaccagaa	12	11	5	13	1	2	1	1	0	1	1	3	1	2	1	3	1	3	1	3	1	5	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:96109029C>G	uc001kjq.1	-	10	1323	c.1235G>C	c.(1234-1236)AGA>ACA	p.R412T	NOC3L_uc009xuk.1_Missense_Mutation_p.R197T	NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	412						nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				TTCGTAATTTCTGCCCTTCAC	0.328													13	45					0	0	0	0	G	96109029	G	G	96109029	3	3	116	1	0	0	0	0	1	0	0	0	10568	913	32	2	1215	2	NOC3L	10	96109029	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	103117	96109029	39425718	200	20897											
LCOR	84458	broad.mit.edu	37	chr10	98715469	98715469	+	Frame_Shift_Del	DEL	A	-	-																															atctcagtggttatgagtggAaaaatgagtgtttccaaagc																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:98715469delA	uc001kms.1	+	8	1613	c.1092delA	c.(1090-1092)GGAfs	p.G364fs	LCOR_uc001kmr.2_Frame_Shift_Del_p.G364fs|C10orf12_uc009xvg.1_Intron|LCOR_uc001kmt.1_Frame_Shift_Del_p.G364fs|LCOR_uc001kmu.1_Frame_Shift_Del_p.G364fs	NM_032440	NP_115816	Q96JN0	LCOR_HUMAN	ligand dependent nuclear receptor corepressor	364	HTH psq-type.					nucleus	DNA binding			ovary(3)	3		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		TTATGAGTGGAAAAATGAGTG	0.468													---	---	---								-	98715469	-	-	98715469	7	5	116	1	0	1	0	1	0	0	0	0	8729	233	9	0	1102	0	LCOR	10	98715469	Frame_Shift_Del	DEL	A	TCGA-CR-5248-01A-01D-2012-08	2606440	98715469	36819278	201	20898											
RRP12	23223	broad.mit.edu	37	chr10	99131844	99131844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcacctctaggtagggccGgatggtggagtatagcttac	8	10	14	9	1	2	0	1	0	1	0	2	2	2	2	2	5	2	4	2	5	5	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:99131844G>A	uc001knf.2	-	20	2468	c.2329C>T	c.(2329-2331)CGG>TGG	p.R777W	RRP12_uc009xvl.2_5'UTR|RRP12_uc009xvm.2_Missense_Mutation_p.R495W|RRP12_uc010qou.1_Missense_Mutation_p.R716W|RRP12_uc009xvn.2_Missense_Mutation_p.R677W	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	777						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		AGGTAGGGCCGGATGGTGGAG	0.622													12	41					0	0	0	0	A	99131844	A	A	99131844	3	1	116	1	0	0	0	0	1	0	0	0	13751	1115	39	1	1624	1	RRP12	10	99131844	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	416375	99131844	36402903	202	20899											
ADRA2A	150	broad.mit.edu	37	chr10	112837979	112837979	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtcatcatcgccgtgttcacGagccgcgcgctcaaggcgcc	6	7	12	16	7	4	0	4	0	0	0	5	1	4	0	3	1	1	2	3	1	1	1	rs12416313	byFrequency	TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:112837979G>C	uc001kzo.2	+	1	1190	c.225G>C	c.(223-225)ACG>ACC	p.T75T		NM_000681	NP_000672	P08913	ADA2A_HUMAN	alpha-2A-adrenergic receptor	60	Cytoplasmic (By similarity).				actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding				0		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	CCGTGTTCACGAGCCGCGCGC	0.647													6	48					0	0	0	0	C	112837979	C	C	112837979	2	2	116	1	0	0	0	0	0	0	0	1	337	1045	37	3		3	ADRA2A	10	112837979	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	13706135	112837979	22696768	203	20900											
HMX3	340784	broad.mit.edu	37	chr10	124896741	124896741	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggaaagcaaaaaggaaggcGaagcggcgccaggcgcggcc	14	0	17	10	5	0	0	0	0	0	0	0	3	0	2	2	6	2	1	2	6	5	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:124896741G>A	uc010quc.1	+	2	568	c.568G>A	c.(568-570)GAA>AAA	p.E190K		NM_001105574	NP_001099044	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	190					cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		AAAGGAAGGCGAAGCGGCGCC	0.652													4	10					0	0	0	0	A	124896741	A	A	124896741	3	1	116	1	0	0	0	0	1	0	0	0	7287	1059	37	1	574	1	HMX3	10	124896741	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	12058762	124896741	10638006	204	20901											
C10orf137	26098	broad.mit.edu	37	chr10	127409947	127409947	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccagcaggaactaccattCttggcaacagcaagaaaagc	15	5	10	11	0	1	1	0	0	1	1	1	2	1	2	2	3	6	3	2	3	6	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:127409947C>G	uc001liq.1	+	2	576	c.283C>G	c.(283-285)CTT>GTT	p.L95V	uc001lim.1_5'Flank|C10orf137_uc001lin.2_Missense_Mutation_p.L95V|C10orf137_uc001lio.1_Missense_Mutation_p.L95V|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	95			L -> F (in a colorectal cancer sample; somatic mutation).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding	p.L95F(1)		ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AACTACCATTCTTGGCAACAG	0.438													10	53					0	0	0	0	G	127409947	G	G	127409947	3	3	116	1	0	0	0	0	1	0	0	0	1600	913	32	2	289	2	C10orf137	10	127409947	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2513206	127409947	8124800	205	20902											
LRRC27	80313	broad.mit.edu	37	chr10	134165110	134165110	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaacactctgtaattttaGaaggaagacagcctcctcca	16	9	6	10	0	1	2	0	0	1	2	3	3	3	3	3	1	2	1	3	1	6	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr10:134165110G>A	uc010quw.1	+	7	1122	c.927_splice	c.e7-1	p.R309_splice	LRRC27_uc001llf.2_Splice_Site_p.E341_splice|LRRC27_uc010quv.1_Splice_Site_p.R309_splice|LRRC27_uc001llg.2_Splice_Site|LRRC27_uc001lli.2_Splice_Site_p.R309_splice|LRRC27_uc001llj.2_Splice_Site_p.R247_splice|LRRC27_uc001llk.3_Splice_Site_p.R182_splice	NM_030626	NP_085129	Q9C0I9	LRC27_HUMAN	leucine rich repeat containing 27 isoform a											ovary(1)	1		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		TGTAATTTTAGAAGGAAGACA	0.483													63	213					0	0	0	0	A	134165110	A	A	134165110	5	1	116	1	0	0	0	0	0	0	1	0	9031	956	33	2	1047	2	LRRC27	10	134165110	Splice_Site	SNP	G	TCGA-CR-5248-01A-01D-2012-08	6755163	134165110	1369637	206	20903											
SIRT3	23410	broad.mit.edu	37	chr11	236149	236149	+	Frame_Shift_Del	DEL	G	-	-																															aaggggcgcgccgggtccaaGggctcaccgcgggccccatg																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:236149delG	uc001lok.3	-	1	214	c.180delC	c.(178-180)CCCfs	p.P60fs	SIRT3_uc001loj.3_Intron|SIRT3_uc010qvm.1_Frame_Shift_Del_p.P60fs|SIRT3_uc010qvn.1_Intron|SIRT3_uc010qvo.1_Frame_Shift_Del_p.P60fs|SIRT3_uc010qvp.1_Frame_Shift_Del_p.P60fs|SIRT3_uc010qvq.1_Intron|SIRT3_uc009ybt.1_Intron|PSMD13_uc010qvr.1_5'Flank|PSMD13_uc001lol.2_5'Flank|PSMD13_uc001loo.2_5'Flank|PSMD13_uc001lon.2_5'Flank|PSMD13_uc001lom.2_5'Flank	NM_012239	NP_036371	Q9NTG7	SIRT3_HUMAN	sirtuin 3 isoform a	60					chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			urinary_tract(1)	1		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		CCGGGTCCAAGGGCTCACCGC	0.701													---	---	---								-	236149	-	-	236149	7	5	116	1	0	1	0	1	0	0	0	0	14404	987	35	0	1047	0	SIRT3	11	236149	Frame_Shift_Del	DEL	G	TCGA-CR-5248-01A-01D-2012-08		236149	134770367	207	20904											
MUC2	4583	broad.mit.edu	37	chr11	1096554	1096554	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgatcaagaccgtgcatatGatgcccatgcaggtgcaggt	10	9	12	10	1	1	3	1	2	0	1	1	3	1	3	2	2	4	3	2	2	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:1096554G>A	uc001lsx.1	+	37	13692	c.13665G>A	c.(13663-13665)ATG>ATA	p.M4555I		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4555	VWFD 4.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCGTGCATATGATGCCCATGC	0.637													5	20					0	0	0	0	A	1096554	A	A	1096554	3	1	116	1	0	0	0	0	1	0	0	0	10028	1290	45	2	6705	2	MUC2	11	1096554	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	860405	1096554	133909962	208	20905											
OR52K2	119774	broad.mit.edu	37	chr11	4470668	4470668	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctggatctccatccctttCtgcttagcatatacactggc	8	14	6	13	0	3	0	0	0	3	0	5	1	4	1	2	2	3	2	2	2	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:4470668C>G	uc001lyz.1	+	1	99	c.99C>G	c.(97-99)TTC>TTG	p.F33L		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATCCCTTTCTGCTTAGCAT	0.517													7	70					0	0	0	0	G	4470668	G	G	4470668	3	3	116	1	0	0	0	0	1	0	0	0	11178	912	32	2	101	2	OR52K2	11	4470668	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3374114	4470668	130535848	209	20906											
CNGA4	1262	broad.mit.edu	37	chr11	6262988	6262988	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagggctctactttggggaGatcagcatcatcaacatcaa	12	9	10	10	0	5	1	4	0	1	1	5	2	5	1	0	3	3	3	0	3	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:6262988G>A	uc001mco.2	+	5	1352	c.1245G>A	c.(1243-1245)GAG>GAA	p.E415E	CNGA4_uc010raa.1_Silent_p.E184E|CNGA4_uc001mcn.2_Silent_p.E375E	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	415	cNMP.|Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTTTGGGGAGATCAGCATCA	0.552													41	69					0	0	0	0	A	6262988	A	A	6262988	2	1	116	1	0	0	0	0	0	0	0	1	3614	933	33	2		2	CNGA4	11	6262988	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1792320	6262988	128743528	210	20907											
ILK	3611	broad.mit.edu	37	chr11	6629392	6629392	+	Frame_Shift_Del	DEL	C	-	-																															aatgaaccgtggggatgacaCccccctgcatctggcagcca																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:6629392delC	uc001mee.2	+	3	341	c.206delC	c.(205-207)ACCfs	p.T69fs	ILK_uc001mef.2_Frame_Shift_Del_p.T69fs|ILK_uc010rap.1_Intron|ILK_uc010raq.1_Frame_Shift_Del_p.T69fs|ILK_uc001meg.2_5'UTR|ILK_uc001meh.2_Frame_Shift_Del_p.T69fs|ILK_uc001mei.2_5'Flank	NM_001014794	NP_001014794	Q13418	ILK_HUMAN	integrin-linked kinase	69	Interaction with LIMS1.|ANK 3.				cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		GGGGATGACACCCCCCTGCAT	0.557													---	---	---								-	6629392	-	-	6629392	7	5	116	1	0	1	0	1	0	0	0	0	7752	507	18	0	212	0	ILK	11	6629392	Frame_Shift_Del	DEL	C	TCGA-CR-5248-01A-01D-2012-08	366404	6629392	128377124	211	20908											
SBF2	81846	broad.mit.edu	37	chr11	9810748	9810748	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggctccgtggcccagcttCtccagccaggtcagagtctt	5	10	11	15	1	3	1	1	0	2	1	5	1	4	1	4	3	2	2	4	3	0	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:9810748C>T	uc001mib.2	-	35	4978	c.4840G>A	c.(4840-4842)GAA>AAA	p.E1614K	uc001mhz.1_Intron|SBF2_uc001mid.2_Missense_Mutation_p.E258K|SBF2_uc001mic.2_5'Flank|uc001mie.3_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1614					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GGCCCAGCTTCTCCAGCCAGG	0.537													15	50					0	0	0	0	T	9810748	T	T	9810748	3	4	116	1	0	0	0	0	1	0	0	0	13924	922	32	2	733	2	SBF2	11	9810748	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3181356	9810748	125195768	212	20909											
SBF2	81846	broad.mit.edu	37	chr11	9810835	9810835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctgtggacagggtctcttCtatgtagtaatcccacttct	7	14	9	11	0	3	0	0	0	3	0	5	1	4	1	2	2	0	2	2	2	3	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:9810835C>T	uc001mib.2	-	35	4891	c.4753G>A	c.(4753-4755)GAA>AAA	p.E1585K	uc001mhz.1_Intron|SBF2_uc001mid.2_Missense_Mutation_p.E229K|SBF2_uc001mic.2_5'Flank|uc001mie.3_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1585					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		AGGGTCTCTTCTATGTAGTAA	0.488													19	75					0	0	0	0	T	9810835	T	T	9810835	3	4	116	1	0	0	0	0	1	0	0	0	13924	922	32	2	820	2	SBF2	11	9810835	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	87	9810835	125195681	213	20910											
CCDC73	493860	broad.mit.edu	37	chr11	32635181	32635181	+	Frame_Shift_Del	DEL	T	-	-																															gtatactggagttttctcagTttttttatctgaagttgaaa																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:32635181delT	uc001mtv.2	-	16	2727	c.2683delA	c.(2683-2685)ACTfs	p.T895fs		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	895										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					GTTTTCTCAGTTTTTTTATCT	0.403													---	---	---								-	32635181	-	-	32635181	7	5	116	1	0	1	0	1	0	0	0	0	2859	1725	60	0	568	0	CCDC73	11	32635181	Frame_Shift_Del	DEL	T	TCGA-CR-5248-01A-01D-2012-08	22824346	32635181	102371335	214	20911											
OR4C46	119749	broad.mit.edu	37	chr11	51515816	51515816	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagatcactttatgtgtgatCtgaaccctttgctcaacctc	9	15	6	11	0	3	3	2	2	1	1	4	3	3	3	2	0	3	1	2	0	4	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:51515816C>T	uc010ric.1	+	1	535	c.535C>T	c.(535-537)CTG>TTG	p.L179L		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TATGTGTGATCTGAACCCTTT	0.458													23	98					0	0	0	0	T	51515816	T	T	51515816	2	4	116	1	0	0	0	0	0	0	0	1	11105	912	32	2		2	OR4C46	11	51515816	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	18880635	51515816	83490700	215	20912											
APLNR	187	broad.mit.edu	37	chr11	57003609	57003609	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcaggtgcagtaggggaaGatgttcatgaggaagaggtc	12	8	17	4	0	1	3	1	1	0	2	2	5	1	5	0	5	2	4	0	5	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:57003609G>T	uc001njo.2	-	1	1319	c.870C>A	c.(868-870)ATC>ATA	p.I290I	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	290	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						AGTAGGGGAAGATGTTCATGA	0.587													5	46					1.23904e-05	1.68671e-05	1	0	T	57003609	T	T	57003609	2	4	116	1	0	0	0	0	0	0	0	1	777	932	33	2		2	APLNR	11	57003609	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5487793	57003609	78002907	216	20913											
OR5B17	219965	broad.mit.edu	37	chr11	58125821	58125821	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaaatggcaatgaggtgaGaaccacaggtagataaaggc	18	5	13	5	0	0	4	0	2	0	3	0	5	0	4	1	4	1	2	1	4	7	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:58125821G>C	uc010rke.1	-	1	722	c.722C>G	c.(721-723)TCT>TGT	p.S241C		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AATGAGGTGAGAACCACAGGT	0.393													8	29					0	0	0	0	C	58125821	C	C	58125821	3	2	116	1	0	0	0	0	1	0	0	0	11203	942	33	2	224	2	OR5B17	11	58125821	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1122212	58125821	76880695	217	20914											
DAGLA	747	broad.mit.edu	37	chr11	61511546	61511546	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caatgggcgcctgggggactCgcccagtcctcaggtgctgg	5	7	16	13	2	1	0	1	0	0	0	3	1	2	1	3	5	1	1	3	5	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:61511546C>T	uc001nsa.2	+	20	2825	c.2714C>T	c.(2713-2715)TCG>TTG	p.S905L		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	905	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		CTGGGGGACTCGCCCAGTCCT	0.652													9	37					0	0	0	0	T	61511546	T	T	61511546	3	4	116	1	0	0	0	0	1	0	0	0	4243	893	31	1	2788	1	DAGLA	11	61511546	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3385725	61511546	73494970	218	20915											
HNRNPUL2	221092	broad.mit.edu	37	chr11	62490138	62490138	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcctcaaattgtccattttCtgccttgagtcctcgtccat	6	17	5	13	1	2	1	1	1	1	0	7	1	6	1	5	0	1	0	5	0	1	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:62490138C>G	uc001nuw.2	-	6	1223	c.1030G>C	c.(1030-1032)GAA>CAA	p.E344Q	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	344	B30.2/SPRY.				cell killing	nucleus	ATP binding|nucleic acid binding				0						TGTCCATTTTCTGCCTTGAGT	0.428													13	55					0	0	0	0	G	62490138	G	G	62490138	3	3	116	1	0	0	0	0	1	0	0	0	7314	922	32	2	1249	2	HNRNPUL2	11	62490138	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	978592	62490138	72516378	219	20916											
FKBP2	2286	broad.mit.edu	37	chr11	64009964	64009964	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaagctgcagatcggggtCaagaagcgggtggaccactg	11	5	17	8	2	1	2	1	0	0	2	2	4	1	4	1	5	3	2	1	5	3	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:64009964C>G	uc001nyy.2	+	2	301	c.105C>G	c.(103-105)GTC>GTG	p.V35V	FKBP2_uc010rnh.1_Silent_p.V35V|FKBP2_uc001nyz.2_Silent_p.V35V	NM_004470	NP_004461	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa precursor	35					protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding				0						AGATCGGGGTCAAGAAGCGGG	0.632													7	76					0	0	0	0	G	64009964	G	G	64009964	2	3	116	1	0	0	0	0	0	0	0	1	5940	813	29	2		2	FKBP2	11	64009964	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1519826	64009964	70996552	220	20917											
CDCA5	113130	broad.mit.edu	37	chr11	64851416	64851416	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgctcaccggagcgctgaGcggctcctccggaccgcgtt	4	7	13	17	7	1	1	1	1	0	0	4	3	4	3	5	3	2	4	5	3	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:64851416G>C	uc001ocp.2	-	1	200	c.35C>G	c.(34-36)GCT>GGT	p.A12G	ZFPL1_uc009yqa.2_5'Flank|ZFPL1_uc001ocq.1_5'Flank|ZFPL1_uc010rnx.1_5'Flank	NM_080668	NP_542399	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	12					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding				0						GGAGCGCTGAGCGGCTCCTCC	0.602													14	51					0	0	0	0	C	64851416	C	C	64851416	3	2	116	1	0	0	0	0	1	0	0	0	3104	971	34	4	747	4	CDCA5	11	64851416	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	841452	64851416	70155100	221	20918											
MAP3K11	4296	broad.mit.edu	37	chr11	65380700	65380700	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacagccttgagggcaatGatgttggggtgtgccagcat	9	9	14	9	0	0	2	0	2	0	0	0	2	0	2	2	3	3	3	2	3	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:65380700G>T	uc001oew.2	-	1	1021	c.528C>A	c.(526-528)ATC>ATA	p.I176I	MAP3K11_uc010rol.1_5'Flank	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	176	Protein kinase.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6						TGAGGGCAATGATGTTGGGGT	0.667													7	51					0.00307968	0.00410624	1	0	T	65380700	T	T	65380700	2	4	116	1	0	0	0	0	0	0	0	1	9298	1280	45	2		2	MAP3K11	11	65380700	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	529284	65380700	69625816	222	20919											
RPS6KB2	6199	broad.mit.edu	37	chr11	67200087	67200087	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaggtggcgagctcttcacGcatctggagcgagagggcat	8	7	16	10	3	3	1	1	0	2	1	3	4	3	2	0	4	2	4	0	4	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:67200087G>A	uc001old.2	+	6	556	c.474G>A	c.(472-474)ACG>ACA	p.T158T	RPS6KB2_uc001olf.2_5'UTR|RPS6KB2_uc001olg.2_Silent_p.T158T|RPS6KB2_uc009yrq.2_5'UTR|RPS6KB2_uc001ole.2_RNA|RPS6KB2_uc001olh.2_RNA|RPS6KB2_uc009yrr.2_Missense_Mutation_p.R23H	NM_003952	NP_003943	Q9UBS0	KS6B2_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide	158	Protein kinase.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of translational initiation|translation	nucleoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|stomach(1)|lung(1)|salivary_gland(1)	7			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			AGCTCTTCACGCATCTGGAGC	0.468													22	74					0	0	0	0	A	67200087	A	A	67200087	2	1	116	1	0	0	0	0	0	0	0	1	13722	1074	38	1		1	RPS6KB2	11	67200087	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1819387	67200087	67806429	223	20920											
PPFIA1	8500	broad.mit.edu	37	chr11	70208451	70208451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgagcaaacgtgaaaagcGgggccatcatgtcggccctg	10	5	14	12	4	1	1	1	1	0	0	2	2	1	1	3	3	3	1	3	3	3	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:70208451G>A	uc001opo.2	+	21	2920	c.2722G>A	c.(2722-2724)GGG>AGG	p.G908R	PPFIA1_uc001opn.1_Missense_Mutation_p.G908R|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opr.2_Missense_Mutation_p.G16R	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	908	SAM 1.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CGTGAAAAGCGGGGCCATCAT	0.607													24	142					0	0	0	0	A	70208451	A	A	70208451	3	1	116	1	0	0	0	0	1	0	0	0	12364	1116	39	1	2800	1	PPFIA1	11	70208451	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3008364	70208451	64798065	224	20921											
FOLR1	2348	broad.mit.edu	37	chr11	71903275	71903275	+	Frame_Shift_Del	DEL	G	-	-																															tagtgtgggtggctgtagtaGgggaggctcagacaaggatt																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:71903275delG	uc001orz.1	+	3	196	c.58delG	c.(58-60)GGGfs	p.G20fs	FOLR1_uc001osa.1_Frame_Shift_Del_p.G20fs|FOLR1_uc001osb.1_Frame_Shift_Del_p.G20fs|FOLR1_uc001osc.1_Frame_Shift_Del_p.G20fs|FOLR1_uc001osd.1_Frame_Shift_Del_p.G20fs	NM_016724	NP_057936	P15328	FOLR1_HUMAN	folate receptor 1 precursor	20					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			ovary(1)	1						GGCTGTAGTAGGGGAGGCTCA	0.552													---	---	---								-	71903275	-	-	71903275	7	5	116	1	0	1	0	1	0	0	0	0	6013	1000	35	0	60	0	FOLR1	11	71903275	Frame_Shift_Del	DEL	G	TCGA-CR-5248-01A-01D-2012-08	1694824	71903275	63103241	225	20922											
YAP1	10413	broad.mit.edu	37	chr11	101981721	101981721	+	Frame_Shift_Del	DEL	C	-	-																															cccaggcggcgccgcaggcaCcccccgccgggcatcagatc																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:101981721delC	uc001pgt.2	+	1	512	c.142delC	c.(142-144)CCCfs	p.P48fs	YAP1_uc001pgs.2_Frame_Shift_Del_p.P48fs|YAP1_uc001pgu.2_Frame_Shift_Del_p.P48fs|YAP1_uc001pgv.2_Frame_Shift_Del_p.P48fs|YAP1_uc010ruo.1_5'Flank	NM_001130145	NP_001123617	P46937	YAP1_HUMAN	Yes-associated protein 1, 65kDa isoform 1	48	Pro-rich.				cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)		GCCGCAGGCACCCCCCGCCGG	0.761													---	---	---								-	101981721	-	-	101981721	7	5	116	1	0	1	0	1	0	0	0	0	17534	507	18	0	144	0	YAP1	11	101981721	Frame_Shift_Del	DEL	C	TCGA-CR-5248-01A-01D-2012-08	30078446	101981721	33024795	226	20923											
LAYN	143903	broad.mit.edu	37	chr11	111428359	111428359	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtatgttgggtttggatctGtagaaaaaggcaagtaaaac	14	12	12	3	0	1	1	0	0	1	1	1	2	1	2	0	3	1	6	0	3	7	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:111428359G>A	uc001plr.1	+	7	1112	c.776G>A	c.(775-777)TGT>TAT	p.C259Y	LAYN_uc001plp.1_Missense_Mutation_p.C251Y|LAYN_uc001plq.1_Missense_Mutation_p.C259Y|LAYN_uc001pls.1_Missense_Mutation_p.C251Y|LAYN_uc010rwg.1_Missense_Mutation_p.C106Y|LAYN_uc010rwh.1_Missense_Mutation_p.C107Y	NM_178834	NP_849156	Q6UX15	LAYN_HUMAN	layilin	259	Cytoplasmic (Potential).					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding				0		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		GTTTGGATCTGTAGAAAAAGG	0.433													40	422					0	0	0	0	A	111428359	A	A	111428359	3	1	116	1	0	0	0	0	1	0	0	0	8689	1377	48	4	774	4	LAYN	11	111428359	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	9446638	111428359	23578157	227	20924											
CRTAM	56253	broad.mit.edu	37	chr11	122720855	122720855	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaaagtgtgtcacttctctGaggaagaactcctccctcca	10	11	7	13	0	2	2	1	1	1	1	6	3	5	3	3	1	1	0	3	1	4	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr11:122720855G>A	uc001pyj.2	+	2	126	c.126G>A	c.(124-126)CTG>CTA	p.L42L		NM_019604	NP_062550	O95727	CRTAM_HUMAN	class-I MHC-restricted T cell associated	42	Ig-like V-type.|Extracellular (Potential).				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			ovary(1)	1		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TCACTTCTCTGAGGAAGAACT	0.483													22	29					0	0	0	0	A	122720855	A	A	122720855	2	1	116	1	0	0	0	0	0	0	0	1	3912	1277	45	2		2	CRTAM	11	122720855	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	11292496	122720855	12285661	228	20925											
C12orf4	57102	broad.mit.edu	37	chr12	4639069	4639069	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcagctccacatctctttCaccaatcagttctgagatac	10	14	4	13	0	5	1	3	1	2	1	7	2	6	1	2	0	2	2	2	0	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:4639069C>T	uc001qms.2	-	4	560	c.472G>A	c.(472-474)GAA>AAA	p.E158K	C12orf4_uc001qmt.2_Missense_Mutation_p.E158K	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	158											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		ACATCTCTTTCACCAATCAGT	0.343													12	59					0	0	0	0	T	4639069	T	T	4639069	3	4	116	1	0	0	0	0	1	0	0	0	1691	835	29	2	1230	2	C12orf4	12	4639069	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		4639069	129212826	229	20926											
SLC2A3	6515	broad.mit.edu	37	chr12	8074141	8074141	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcctcaaaagtcctgccacgGgtctcagggactttgaagaa	11	9	10	11	1	2	2	2	1	1	1	5	3	4	3	3	2	1	0	3	2	4	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:8074141G>A	uc001qtr.2	-	10	1621	c.1359C>T	c.(1357-1359)ACC>ACT	p.T453T		NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	453	Cytoplasmic (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		TCCTGCCACGGGTCTCAGGGA	0.488													21	79					0	0	0	0	A	8074141	A	A	8074141	2	1	116	1	0	0	0	0	0	0	0	1	14609	1219	43	4		4	SLC2A3	12	8074141	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3435072	8074141	125777754	230	20927											
ATF7IP	55729	broad.mit.edu	37	chr12	14578131	14578131	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatatcttagaaaatacaGactctatggagacagatgaa	19	9	8	5	0	2	6	0	1	2	5	2	7	2	6	0	1	1	0	0	1	8	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:14578131G>T	uc001rbw.2	+	2	1440	c.1282G>T	c.(1282-1284)GAC>TAC	p.D428Y	ATF7IP_uc010shs.1_Missense_Mutation_p.D428Y|ATF7IP_uc001rbu.2_Missense_Mutation_p.D428Y|ATF7IP_uc001rbv.1_Missense_Mutation_p.D428Y|ATF7IP_uc001rbx.2_Missense_Mutation_p.D428Y|ATF7IP_uc010sht.1_Missense_Mutation_p.D428Y|ATF7IP_uc001rby.3_Missense_Mutation_p.D428Y|ATF7IP_uc001rbz.1_Missense_Mutation_p.D428Y|ATF7IP_uc001rca.2_Missense_Mutation_p.D428Y|ATF7IP_uc001rcb.2_Missense_Mutation_p.D39Y	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	428	Glu-rich.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						AGAAAATACAGACTCTATGGA	0.333													9	49					0.00448238	0.00596289	1	0	T	14578131	T	T	14578131	3	4	116	1	0	0	0	0	1	0	0	0	1089	942	33	2	1284	2	ATF7IP	12	14578131	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	6503990	14578131	119273764	231	20928											
C12orf60	144608	broad.mit.edu	37	chr12	14976214	14976214	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtcagctaaagaagtattCaaaagtgcccatacgccagt	15	8	8	10	1	2	1	2	0	0	1	2	1	2	1	2	0	3	2	2	0	7	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:14976214C>G	uc001rcj.3	+	2	549	c.345C>G	c.(343-345)TTC>TTG	p.F115L		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	115										ovary(1)|central_nervous_system(1)	2						AAGAAGTATTCAAAAGTGCCC	0.433													25	75					0	0	0	0	G	14976214	G	G	14976214	3	3	116	1	0	0	0	0	1	0	0	0	1709	825	29	2	347	2	C12orf60	12	14976214	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	398083	14976214	118875681	232	20929											
ITPR2	3709	broad.mit.edu	37	chr12	26714879	26714879	+	Frame_Shift_Del	DEL	T	-	-																															ctggaatggcaattccacgaTtttttgctgaaaaagaaaga																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:26714879delT	uc001rhg.2	-	35	5054	c.4637delA	c.(4636-4638)AATfs	p.N1546fs		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1546	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AATTCCACGATTTTTTGCTGA	0.318													---	---	---								-	26714879	-	-	26714879	7	5	116	1	0	1	0	1	0	0	0	0	7960	1493	52	0	3560	0	ITPR2	12	26714879	Frame_Shift_Del	DEL	T	TCGA-CR-5248-01A-01D-2012-08	11738665	26714879	107137016	233	20930											
DDX11	1663	broad.mit.edu	37	chr12	31255377	31255377	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaggcctgtggccaggagaGaggccaggtgacaggggccc	9	3	18	11	0	0	2	0	1	0	1	0	4	0	3	4	7	0	0	4	7	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:31255377G>C	uc001rjt.1	+	23	2539	c.2288G>C	c.(2287-2289)AGA>ACA	p.R763T	DDX11_uc001rjr.1_Missense_Mutation_p.R763T|DDX11_uc001rjs.1_Missense_Mutation_p.R713T|DDX11_uc001rju.1_Missense_Mutation_p.R435T|DDX11_uc001rjv.1_Missense_Mutation_p.R763T|DDX11_uc001rjw.1_Missense_Mutation_p.R737T|DDX11_uc009zjn.1_RNA|DDX11_uc009zjo.1_5'UTR	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	763					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GGCCAGGAGAGAGGCCAGGTG	0.562										Multiple Myeloma(12;0.14)			28	98					0	0	0	0	C	31255377	C	C	31255377	3	2	116	1	0	0	0	0	1	0	0	0	4360	942	33	2	2374	2	DDX11	12	31255377	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	4540498	31255377	102596518	234	20931											
OR6C76	390326	broad.mit.edu	37	chr12	55820433	55820433	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctgcattatacaaccatCatgagtgacaggatctgtta	12	12	7	10	0	3	2	1	2	2	0	3	3	3	3	2	1	3	2	2	1	4	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:55820433C>A	uc010spm.1	+	1	396	c.396C>A	c.(394-396)ATC>ATA	p.I132I		NM_001005183	NP_001005183	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATACAACCATCATGAGTGACA	0.433													22	108					3.76869e-24	5.43436e-24	1	0	A	55820433	A	A	55820433	2	1	116	1	0	0	0	0	0	0	0	1	11254	816	29	2		2	OR6C76	12	55820433	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	24565056	55820433	78031462	235	20932											
ITGA7	3679	broad.mit.edu	37	chr12	56096885	56096885	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtctcctccaggctcaacGggcaagcgaagaggcctcca	10	5	11	15	2	2	1	1	0	1	1	5	2	4	1	4	3	2	2	4	3	3	0	rs143749139	byFrequency	TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:56096885G>A	uc001shh.2	-	2	504	c.284C>T	c.(283-285)CCG>CTG	p.P95L	ITGA7_uc001shg.2_Missense_Mutation_p.P95L|ITGA7_uc010sps.1_Intron|ITGA7_uc009znx.2_5'Flank	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	95	FG-GAP 1.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						CAGGCTCAACGGGCAAGCGAA	0.652													19	61					0	0	0	0	A	56096885	A	A	56096885	3	1	116	1	0	0	0	0	1	0	0	0	7920	1116	39	1	3403	1	ITGA7	12	56096885	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	276452	56096885	77755010	236	20933											
ESYT1	23344	broad.mit.edu	37	chr12	56522298	56522298	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggaggcggttgctggtgctGatacctgtgtatttggccgg	4	12	18	7	2	0	1	0	1	0	0	0	2	0	2	2	6	3	4	2	6	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:56522298G>C	uc001sjq.2	+	1	245	c.195G>C	c.(193-195)CTG>CTC	p.L65L	ESYT1_uc001sjr.2_Silent_p.L65L	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	65	Helical; (Potential).					integral to membrane				ovary(4)|skin(1)	5						TGCTGGTGCTGATACCTGTGT	0.672													5	15					0	0	0	0	C	56522298	C	C	56522298	2	2	116	1	0	0	0	0	0	0	0	1	5288	1277	45	2		2	ESYT1	12	56522298	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	425413	56522298	77329597	237	20934											
AGAP2	116986	broad.mit.edu	37	chr12	58128428	58128428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaggaatcggtggatgagcGatgacttcccactcctggca	9	9	12	11	2	1	2	1	2	0	0	4	5	3	4	2	4	1	1	2	4	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:58128428G>A	uc001spq.2	-	3	1262	c.1262C>T	c.(1261-1263)TCG>TTG	p.S421L	AGAP2_uc001spp.2_Missense_Mutation_p.S421L|AGAP2_uc001spr.2_Missense_Mutation_p.S85L	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	421	G domain.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						GTGGATGAGCGATGACTTCCC	0.537													51	151					0	0	0	0	A	58128428	A	A	58128428	3	1	116	1	0	0	0	0	1	0	0	0	368	1059	37	1	2384	1	AGAP2	12	58128428	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1606130	58128428	75723467	238	20935											
PTPRB	5787	broad.mit.edu	37	chr12	70963581	70963581	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacgtgcttgggaatagtctGagagtcaaccttttgactgt	9	13	12	7	1	2	2	1	2	1	1	2	5	2	3	1	1	2	1	1	1	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:70963581G>A	uc001swb.3	-	12	2884	c.2854C>T	c.(2854-2856)CAG>TAG	p.Q952*	PTPRB_uc010sto.1_Nonsense_Mutation_p.Q952*|PTPRB_uc010stp.1_Nonsense_Mutation_p.Q862*|PTPRB_uc001swc.3_Nonsense_Mutation_p.Q1170*|PTPRB_uc001swa.3_Nonsense_Mutation_p.Q1082*|PTPRB_uc001swd.3_Nonsense_Mutation_p.Q1169*|PTPRB_uc009zrr.1_Nonsense_Mutation_p.Q1049*	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	952	Fibronectin type-III 11.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGAATAGTCTGAGAGTCAACC	0.547													12	55					0	0	0	0	A	70963581	A	A	70963581	4	1	116	1	0	0	0	0	0	1	0	0	12861	1299	45	2	3223	2	PTPRB	12	70963581	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	12835153	70963581	62888314	239	20936											
NAV3	89795	broad.mit.edu	37	chr12	78574787	78574787	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggcagtcattaggactttCtctaaacaatttgaacatca	14	12	6	9	0	3	1	2	1	1	0	4	2	3	2	0	2	2	1	0	2	5	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:78574787C>G	uc001syp.2	+	30	5827	c.5654C>G	c.(5653-5655)TCT>TGT	p.S1885C	NAV3_uc001syo.2_Missense_Mutation_p.S1863C|NAV3_uc010sub.1_Missense_Mutation_p.S1342C|NAV3_uc009zsf.2_Missense_Mutation_p.S694C	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1885	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TTAGGACTTTCTCTAAACAAT	0.483										HNSCC(70;0.22)			21	89					0	0	0	0	G	78574787	G	G	78574787	3	3	116	1	0	0	0	0	1	0	0	0	10238	913	32	2	5702	2	NAV3	12	78574787	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	7611206	78574787	55277108	240	20937											
METAP2	10988	broad.mit.edu	37	chr12	95868071	95868071	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaagcagccaagaaaaaaaGacgaaagaagaagaagagca	24	0	12	5	1	0	6	0	0	0	6	0	8	0	7	1	1	3	2	1	1	9	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:95868071G>C	uc001tec.2	+	1	250	c.116G>C	c.(115-117)AGA>ACA	p.R39T	METAP2_uc010suv.1_Missense_Mutation_p.R39T|METAP2_uc009ztd.2_Missense_Mutation_p.R39T|METAP2_uc001ted.2_Missense_Mutation_p.R39T|METAP2_uc001tef.2_Missense_Mutation_p.R39T|METAP2_uc001tee.2_RNA	NM_006838	NP_006829	P50579	AMPM2_HUMAN	methionyl aminopeptidase 2	39	Arg/Lys-rich (basic).				N-terminal protein amino acid modification|peptidyl-methionine modification|protein processing|proteolysis	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0					L-Methionine(DB00134)	AAGAAAAAAAGACGAAAGAAG	0.557													15	68					0	0	0	0	C	95868071	C	C	95868071	3	2	116	1	0	0	0	0	1	0	0	0	9540	942	33	2	118	2	METAP2	12	95868071	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	17293284	95868071	37983824	241	20938											
C12orf63	374467	broad.mit.edu	37	chr12	97078851	97078851	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctcttgatgacatattcaGaaaaccagacgtgctacaca	15	9	7	10	1	2	4	1	2	1	2	2	4	2	4	1	0	4	2	1	0	4	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:97078851G>C	uc001tet.1	+	9	1202	c.1124G>C	c.(1123-1125)AGA>ACA	p.R375T		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	375										skin(6)|ovary(1)	7						GACATATTCAGAAAACCAGAC	0.433													8	32					0	0	0	0	C	97078851	C	C	97078851	3	2	116	1	0	0	0	0	1	0	0	0	1712	942	33	2	1154	2	C12orf63	12	97078851	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1210780	97078851	36773044	242	20939											
ANKS1B	56899	broad.mit.edu	37	chr12	99793498	99793498	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gactggcagtaaagcttgtgCaccctgtagatgtgttgatt	9	13	12	7	0	0	2	0	1	0	1	0	3	0	2	1	1	2	6	1	1	3	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:99793498C>T	uc001tge.1	-	12	2084	c.1667G>A	c.(1666-1668)TGC>TAC	p.C556Y	ANKS1B_uc001tgf.1_Missense_Mutation_p.C136Y|ANKS1B_uc009ztt.1_Missense_Mutation_p.C522Y	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	556						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		AAAGCTTGTGCACCCTGTAGA	0.428													25	74					0	0	0	0	T	99793498	T	T	99793498	3	4	116	1	0	0	0	0	1	0	0	0	689	710	25	4	2427	4	ANKS1B	12	99793498	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2714647	99793498	34058397	243	20940											
NAA25	80018	broad.mit.edu	37	chr12	112492367	112492367	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctgccacacagtggtctCatcacctagaaccaaaatac	13	7	7	14	0	2	1	2	0	1	1	3	1	2	1	4	2	3	0	4	2	5	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:112492367C>T	uc001ttm.2	-	14	1473	c.1453G>A	c.(1453-1455)GAG>AAG	p.E485K	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.E457K|NAA25_uc009zwa.1_Missense_Mutation_p.E485K	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	485						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						ACAGTGGTCTCATCACCTAGA	0.433													9	15					0	0	0	0	T	112492367	T	T	112492367	3	4	116	1	0	0	0	0	1	0	0	0	10174	835	29	2	1509	2	NAA25	12	112492367	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	12698869	112492367	21359528	244	20941											
C12orf51	283450	broad.mit.edu	37	chr12	112605283	112605283	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atccccagcagctgccccagGaagtgcagcagctgctcctc	8	6	10	17	0	0	0	0	0	0	0	3	1	2	1	5	1	7	6	5	1	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:112605283G>A	uc009zwc.2	-	65	11124	c.11106C>T	c.(11104-11106)TTC>TTT	p.F3702F		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GCTGCCCCAGGAAGTGCAGCA	0.662													14	43					0	0	0	0	A	112605283	A	A	112605283	2	1	116	1	0	0	0	0	0	0	0	1	1702	1165	41	2		2	C12orf51	12	112605283	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	112916	112605283	21246612	245	20942											
EP400	57634	broad.mit.edu	37	chr12	132554096	132554096	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagaaggttgcctacgccgcGcagccggcccttaagaccca	9	5	11	16	4	0	2	0	0	0	2	0	2	0	2	5	2	3	2	5	2	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr12:132554096G>A	uc001ujn.2	+	50	8966	c.8931G>A	c.(8929-8931)GCG>GCA	p.A2977A	EP400_uc001ujl.2_Silent_p.A2976A|EP400_uc001ujm.2_Silent_p.A2896A|EP400_uc001ujp.2_Silent_p.A187A	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	3013					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCTACGCCGCGCAGCCGGCCC	0.647													18	106					0	0	0	0	A	132554096	A	A	132554096	2	1	116	1	0	0	0	0	0	0	0	1	5173	1074	38	1		1	EP400	12	132554096	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	19948813	132554096	1297799	246	20943											
MPHOSPH8	54737	broad.mit.edu	37	chr13	20235942	20235942	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtgaacggtcggcagaaGaacgggaccaccgccctcat	13	4	12	12	4	1	3	1	1	0	2	2	4	1	4	3	3	2	1	3	3	4	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr13:20235942G>T	uc001umh.2	+	8	1905	c.1896G>T	c.(1894-1896)AAG>AAT	p.K632N	MPHOSPH8_uc001umg.2_Missense_Mutation_p.K632N	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	632					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		GTCGGCAGAAGAACGGGACCA	0.562													33	76					5.91797e-21	8.51254e-21	1	0	T	20235942	T	T	20235942	3	4	116	1	0	0	0	0	1	0	0	0	9780	933	33	2	1926	2	MPHOSPH8	13	20235942	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08		20235942	94933936	247	20944											
MTMR6	9107	broad.mit.edu	37	chr13	25840348	25840348	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattcctcagcgagatcaatGagctgccagccttgtagtcg	9	11	10	11	2	2	2	2	1	0	1	4	3	3	2	3	0	4	2	3	0	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr13:25840348G>C	uc001uqf.3	-	4	700	c.381C>G	c.(379-381)CTC>CTG	p.L127L	MTMR6_uc001uqe.1_Silent_p.L127L	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	127	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		CGAGATCAATGAGCTGCCAGC	0.393													12	23					0	0	0	0	C	25840348	C	C	25840348	2	2	116	1	0	0	0	0	0	0	0	1	10000	1277	45	2		2	MTMR6	13	25840348	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5604406	25840348	89329530	248	20945											
MTMR6	9107	broad.mit.edu	37	chr13	25842002	25842002	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgcacagttctgaagttCttgcactgtatcacaagggg	12	11	10	8	0	3	1	1	1	2	0	3	1	3	1	0	2	2	5	0	2	4	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr13:25842002C>G	uc001uqf.3	-	3	538	c.219G>C	c.(217-219)AAG>AAC	p.K73N	MTMR6_uc001uqe.1_Missense_Mutation_p.K73N	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	73						cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		TTCTGAAGTTCTTGCACTGTA	0.393													12	29					0	0	0	0	G	25842002	G	G	25842002	3	3	116	1	0	0	0	0	1	0	0	0	10000	912	32	2	1694	2	MTMR6	13	25842002	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1654	25842002	89327876	249	20946											
ELF1	1997	broad.mit.edu	37	chr13	41517197	41517197	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttaaaaatgcctttctctcGctgggtccacttgatgtatt	8	17	7	9	1	1	1	0	1	1	0	4	1	2	1	2	1	1	2	2	1	4	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr13:41517197G>A	uc001uxs.2	-	7	1070	c.697C>T	c.(697-699)CGA>TGA	p.R233*	ELF1_uc010tfc.1_Nonsense_Mutation_p.R209*|ELF1_uc010acd.2_Nonsense_Mutation_p.R126*	NM_172373	NP_758961	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription	233	ETS.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		CCTTTCTCTCGCTGGGTCCAC	0.408													16	46					0	0	0	0	A	41517197	A	A	41517197	4	1	116	1	0	0	0	0	0	1	0	0	5077	1095	38	1	1174	1	ELF1	13	41517197	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	15675195	41517197	73652681	250	20947											
ZNF828	283489	broad.mit.edu	37	chr13	115090767	115090767	+	Frame_Shift_Del	DEL	T	-	-																															ctgatctctggaagtcttccTtttttattgagcctcagaaa																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr13:115090767delT	uc010ahb.2	+	3	1779	c.1450delT	c.(1450-1452)TTTfs	p.F484fs	ZNF828_uc001vuv.2_Frame_Shift_Del_p.F484fs|ZNF828_uc010tko.1_Frame_Shift_Del_p.F484fs	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	484	Mediates localization to the spindle and the kinetochore and is required for the attachment of spindle microtubules to the kinetochore.|Mediates interaction with MAD2L2.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		GAAGTCTTCCTTTTTTATTGA	0.507													---	---	---								-	115090767	-	-	115090767	7	5	116	1	0	1	0	1	0	0	0	0	18248	1609	56	0	1452	0	ZNF828	13	115090767	Frame_Shift_Del	DEL	T	TCGA-CR-5248-01A-01D-2012-08	73573570	115090767	79111	251	20948											
RNASE9	390443	broad.mit.edu	37	chr14	21025129	21025129	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttatcttcttctgggaaatCaaaatctgtatccacctctt	10	17	4	10	0	6	0	1	0	5	0	7	1	7	1	2	1	0	1	2	1	5	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:21025129C>G	uc010aho.2	-	4	259	c.100G>C	c.(100-102)GAT>CAT	p.D34H	RNASE9_uc001vxq.3_Missense_Mutation_p.D39H|RNASE9_uc010ahp.2_Missense_Mutation_p.D39H|RNASE9_uc010ahq.2_Missense_Mutation_p.D39H|RNASE9_uc010ahr.2_Missense_Mutation_p.D39H|RNASE9_uc010ahs.2_Missense_Mutation_p.D34H|RNASE9_uc010aht.2_Missense_Mutation_p.D34H|RNASE9_uc010ahu.2_Missense_Mutation_p.D34H	NM_001110357	NP_001103827	P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	34						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(2)	2	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		TCTGGGAAATCAAAATCTGTA	0.438													14	45					0	0	0	0	G	21025129	G	G	21025129	3	3	116	1	0	0	0	0	1	0	0	0	13475	826	29	2	521	2	RNASE9	14	21025129	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		21025129	86324411	252	20949											
PSMB5	5693	broad.mit.edu	37	chr14	23495350	23495350	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gatcagccacattgtcactgGagactcggatccagccatcc	10	8	9	14	1	2	1	2	0	0	1	5	4	4	2	4	2	2	0	4	2	0	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:23495350G>C	uc001wii.2	-	3	1004	c.740C>G	c.(739-741)TCC>TGC	p.S247C	PSMB5_uc001wij.2_3'UTR|PSMB5_uc010tni.1_Missense_Mutation_p.S144C	NM_002797	NP_002788	P28074	PSB5_HUMAN	proteasome beta 5 subunit isoform 1	247					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus	protein binding|threonine-type endopeptidase activity			ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0121)	Bortezomib(DB00188)	ATTGTCACTGGAGACTCGGAT	0.552													4	158					0	0	0	0	C	23495350	C	C	23495350	3	2	116	1	0	0	0	0	1	0	0	0	12742	1174	41	2	55	2	PSMB5	14	23495350	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2470221	23495350	83854190	253	20950											
AKAP6	9472	broad.mit.edu	37	chr14	33147558	33147558	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggaagcacaaagagatgcTgttgagcagatgtccctcaa	13	8	11	9	0	1	3	1	1	0	2	2	5	2	4	1	1	3	4	1	1	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:33147558T>G	uc001wrq.2	+	8	2942	c.2772T>G	c.(2770-2772)GCT>GCG	p.A924A	AKAP6_uc010aml.2_Silent_p.A921A	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	924					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AAAGAGATGCTGTTGAGCAGA	0.438													4	23					0	0	0	0	G	33147558	G	G	33147558	2	3	116	1	0	0	0	0	0	0	0	1	455	1567	55	5		5	AKAP6	14	33147558	Silent	SNP	T	TCGA-CR-5248-01A-01D-2012-08	9652208	33147558	74201982	254	20951											
AKAP6	9472	broad.mit.edu	37	chr14	33293569	33293569	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaatctgcagttcccagcGaagctgcaatgccactacaa	13	8	8	12	1	1	1	0	1	1	0	2	2	2	1	2	0	6	4	2	0	5	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:33293569G>A	uc001wrq.2	+	13	6720	c.6550G>A	c.(6550-6552)GAA>AAA	p.E2184K		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2184					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AGTTCCCAGCGAAGCTGCAAT	0.458													8	22					0	0	0	0	A	33293569	A	A	33293569	3	1	116	1	0	0	0	0	1	0	0	0	455	1059	37	1	6596	1	AKAP6	14	33293569	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	146011	33293569	74055971	255	20952											
L2HGDH	79944	broad.mit.edu	37	chr14	50750625	50750625	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggactttctttagccatttCaataccttttacttcaaaat	12	17	3	9	0	3	0	2	0	1	0	3	1	3	1	2	1	3	0	2	1	6	8			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:50750625C>T	uc001wxu.2	-	5	746	c.667G>A	c.(667-669)GAA>AAA	p.E223K	L2HGDH_uc010tqn.1_Missense_Mutation_p.E223K|L2HGDH_uc010tqo.1_Missense_Mutation_p.E223K	NM_024884	NP_079160	Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase precursor	223					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)					TTAGCCATTTCAATACCTTTT	0.338													19	55					0	0	0	0	T	50750625	T	T	50750625	3	4	116	1	0	0	0	0	1	0	0	0	8630	835	29	2	748	2	L2HGDH	14	50750625	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	17457056	50750625	56598915	256	20953											
PYGL	5836	broad.mit.edu	37	chr14	51411035	51411035	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgccggttgaaactcttCttcagctctgccacgttctc	6	13	9	13	2	5	1	1	1	4	0	6	1	5	1	2	2	4	3	2	2	1	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:51411035C>T	uc001wyu.2	-	1	214	c.87G>A	c.(85-87)AAG>AAA	p.K29K	PYGL_uc010tqq.1_Silent_p.K29K|PYGL_uc001wyv.2_5'UTR|PYGL_uc001wyw.3_Silent_p.K29K	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	29					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TGAAACTCTTCTTCAGCTCTG	0.632													18	38					0	0	0	0	T	51411035	T	T	51411035	2	4	116	1	0	0	0	0	0	0	0	1	12926	912	32	2		2	PYGL	14	51411035	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	660410	51411035	55938505	257	20954											
ADAM20	8748	broad.mit.edu	37	chr14	70991263	70991263	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctcatgtggacaatgtatCtctgtcccccaaaccgcagg	9	9	8	15	1	2	0	1	0	1	0	4	1	3	1	4	2	1	2	4	2	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:70991263C>G	uc001xme.2	-	2	607	c.362G>C	c.(361-363)AGA>ACA	p.R121T		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	71					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GACAATGTATCTCTGTCCCCC	0.532													23	73					0	0	0	0	G	70991263	G	G	70991263	3	3	116	1	0	0	0	0	1	0	0	0	242	913	32	2	1972	2	ADAM20	14	70991263	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	19580228	70991263	36358277	258	20955											
ADAM20	8748	broad.mit.edu	37	chr14	70991307	70991307	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taggagagccatccaggagcCtttgcacctctgcccctgct	7	9	10	15	0	1	1	0	0	1	1	2	3	2	2	6	2	5	2	6	2	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:70991307C>A	uc001xme.2	-	2	563	c.318G>T	c.(316-318)AAG>AAT	p.K106N		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	56					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		ATCCAGGAGCCTTTGCACCTC	0.522													22	69					1.50039e-11	2.11139e-11	1	0	A	70991307	A	A	70991307	3	1	116	1	0	0	0	0	1	0	0	0	242	680	24	4	2016	4	ADAM20	14	70991307	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	44	70991307	36358233	259	20956											
PCNX	22990	broad.mit.edu	37	chr14	71576209	71576209	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctggaagggatcaacctgtCtaaaaggaaagagctacagt	15	8	11	7	0	3	1	1	0	2	1	3	4	3	4	1	3	3	1	1	3	6	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:71576209C>G	uc001xmo.2	+	35	7231	c.6785C>G	c.(6784-6786)TCT>TGT	p.S2262C	PCNX_uc010are.1_Missense_Mutation_p.S2151C|PCNX_uc010arf.1_Missense_Mutation_p.S1050C|PCNX_uc001xmp.2_Missense_Mutation_p.S346C	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	2262						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		ATCAACCTGTCTAAAAGGAAA	0.408													11	37					0	0	0	0	G	71576209	G	G	71576209	3	3	116	1	0	0	0	0	1	0	0	0	11645	913	32	2	6923	2	PCNX	14	71576209	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	584902	71576209	35773331	260	20957											
PCNX	22990	broad.mit.edu	37	chr14	71576247	71576247	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggcctgatgaaggaatcCggttaaaagctgggagaaat	14	8	14	5	1	0	3	0	2	0	1	1	5	1	4	2	4	1	2	2	4	5	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:71576247C>T	uc001xmo.2	+	35	7269	c.6823C>T	c.(6823-6825)CGG>TGG	p.R2275W	PCNX_uc010are.1_Missense_Mutation_p.R2164W|PCNX_uc010arf.1_Missense_Mutation_p.R1063W|PCNX_uc001xmp.2_Missense_Mutation_p.R359W	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	2275						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGAAGGAATCCGGTTAAAAGC	0.473													12	47					0	0	0	0	T	71576247	T	T	71576247	3	4	116	1	0	0	0	0	1	0	0	0	11645	643	23	1	6961	1	PCNX	14	71576247	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	38	71576247	35773293	261	20958											
SIPA1L1	26037	broad.mit.edu	37	chr14	72055532	72055532	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagtcatcagatcttgaaGataaccgatcagaagactct	15	9	9	8	1	5	5	3	1	2	4	5	7	5	6	1	1	1	0	1	1	4	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:72055532G>A	uc001xms.2	+	2	1291	c.943G>A	c.(943-945)GAT>AAT	p.D315N	SIPA1L1_uc001xmt.2_Missense_Mutation_p.D315N|SIPA1L1_uc001xmu.2_Missense_Mutation_p.D315N|SIPA1L1_uc001xmv.2_Missense_Mutation_p.D315N	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	315					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AGATCTTGAAGATAACCGATC	0.408													14	50					0	0	0	0	A	72055532	A	A	72055532	3	1	116	1	0	0	0	0	1	0	0	0	14394	942	33	2	945	2	SIPA1L1	14	72055532	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	479285	72055532	35294008	262	20959											
TMED10	10972	broad.mit.edu	37	chr14	75643164	75643164	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcacggaggcacttgcgaGagttaatgggcagatggaag	11	7	15	8	2	1	2	1	0	0	2	1	5	1	4	1	4	1	3	1	4	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:75643164G>C	uc001xrm.1	-	1	186	c.119C>G	c.(118-120)TCT>TGT	p.S40C	TMED10_uc010ash.1_RNA	NM_006827	NP_006818	P49755	TMEDA_HUMAN	transmembrane emp24 domain-containing protein 10	40	Lumenal (Potential).				protein transport|regulated secretory pathway|vesicle targeting, to, from or within Golgi	cis-Golgi network|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|melanosome|microsome|zymogen granule membrane	protein binding				0				BRCA - Breast invasive adenocarcinoma(234;0.0126)		GCACTTGCGAGAGTTAATGGG	0.622													5	100					0	0	0	0	C	75643164	C	C	75643164	3	2	116	1	0	0	0	0	1	0	0	0	16069	942	33	2	560	2	TMED10	14	75643164	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3587632	75643164	31706376	263	20960											
VASH1	22846	broad.mit.edu	37	chr14	77239553	77239553	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggaagccgtgatcctgggaAtgtatccttcctcacctgaa	9	11	10	11	1	1	2	1	2	0	0	4	4	4	4	5	2	1	1	5	2	4	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:77239553A>G	uc001xst.2	+	4	1459	c.529A>G	c.(529-531)ATT>GTT	p.I177V	VASH1_uc001xss.2_Missense_Mutation_p.M177V	NM_014909	NP_055724	Q7L8A9	VASH1_HUMAN	vasohibin 1	177					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		GATCCTGGGAATGTATCCTTC	0.388													12	35					0	0	0	0	G	77239553	G	G	77239553	3	3	116	1	0	0	0	0	1	0	0	0	17193	115	4	5	543	5	VASH1	14	77239553	Missense_Mutation	SNP	A	TCGA-CR-5248-01A-01D-2012-08	1596389	77239553	30109987	264	20961											
C14orf49	161176	broad.mit.edu	37	chr14	95932570	95932570	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagtgcagccacacccactCgatgcggctgtgggcacaga	9	5	12	15	2	0	1	0	0	0	1	1	2	0	1	3	2	3	3	3	2	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:95932570C>T	uc001yei.3	-	3	340	c.325G>A	c.(325-327)GAG>AAG	p.E109K	C14orf49_uc010avi.2_Missense_Mutation_p.E109K|C14orf49_uc001yej.1_Missense_Mutation_p.E109K	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	109	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		CACACCCACTCGATGCGGCTG	0.617													12	73					0	0	0	0	T	95932570	T	T	95932570	3	4	116	1	0	0	0	0	1	0	0	0	1782	893	31	1	2662	1	C14orf49	14	95932570	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	18693017	95932570	11416970	265	20962											
SETD3	84193	broad.mit.edu	37	chr14	99925500	99925500	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcattagcaattttcgtggaAcccataaaaacaattcttct	14	14	4	9	1	3	0	1	0	2	0	4	1	3	1	1	1	3	1	1	1	7	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:99925500A>G	uc001ygc.2	-	5	538	c.368T>C	c.(367-369)GTT>GCT	p.V123A	SETD3_uc001ygd.2_Missense_Mutation_p.V123A|SETD3_uc001ygf.2_Missense_Mutation_p.V123A	NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	123	SET.				peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				TTTTCGTGGAACCCATAAAAA	0.343													12	92					0	0	0	0	G	99925500	G	G	99925500	3	3	116	1	0	0	0	0	1	0	0	0	14197	43	2	5	1498	5	SETD3	14	99925500	Missense_Mutation	SNP	A	TCGA-CR-5248-01A-01D-2012-08	3992930	99925500	7424040	266	20963											
RAGE	5891	broad.mit.edu	37	chr14	102732245	102732245	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgtaggttgttgacttgctCaatactatcgtgtaggtaaa	10	15	10	6	2	1	1	1	1	0	0	3	1	1	1	0	2	2	6	0	2	7	8			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:102732245C>G	uc001ylm.2	-	3	353	c.127G>C	c.(127-129)GAG>CAG	p.E43Q	RAGE_uc010txv.1_Intron|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	43	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TTGACTTGCTCAATACTATCG	0.378													6	32					0	0	0	0	G	102732245	G	G	102732245	3	3	116	1	0	0	0	0	1	0	0	0	13071	835	29	2	1172	2	RAGE	14	102732245	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2806745	102732245	4617295	267	20964											
ZNF839	55778	broad.mit.edu	37	chr14	102805529	102805529	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaacagcagaggccgggaGaagcccaggcccttgcatgc	10	3	14	14	1	0	2	0	0	0	2	0	3	0	2	4	3	5	2	4	3	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:102805529G>A	uc001ylo.2	+	7	1898	c.1548G>A	c.(1546-1548)GAG>GAA	p.E516E	ZNF839_uc010awk.1_Silent_p.E632E|ZNF839_uc001ylp.2_RNA|ZNF839_uc001ylq.1_Silent_p.E516E|ZNF839_uc001ylr.2_Silent_p.E441E|ZNF839_uc001yls.2_Silent_p.E131E|ZNF839_uc001ylt.2_Silent_p.E106E	NM_018335	NP_060805	A8K0R7	ZN839_HUMAN	zinc finger protein 839	516						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GAGGCCGGGAGAAGCCCAGGC	0.582													6	23					0	0	0	0	A	102805529	A	A	102805529	2	1	116	1	0	0	0	0	0	0	0	1	18255	933	33	2		2	ZNF839	14	102805529	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	73284	102805529	4544011	268	20965											
TECPR2	9895	broad.mit.edu	37	chr14	102901519	102901519	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctgagccggctgggtgcaGaggacgccgggctgctcaag	7	5	17	12	3	1	2	1	1	0	1	1	3	1	3	3	4	3	4	3	4	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:102901519G>C	uc001ylw.1	+	9	2513	c.2365G>C	c.(2365-2367)GAG>CAG	p.E789Q	TECPR2_uc010awl.2_Missense_Mutation_p.E789Q|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	789							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						GCTGGGTGCAGAGGACGCCGG	0.552													19	92					0	0	0	0	C	102901519	C	C	102901519	3	2	116	1	0	0	0	0	1	0	0	0	15810	943	33	2	2395	2	TECPR2	14	102901519	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	95990	102901519	4448021	269	20966											
CKB	1152	broad.mit.edu	37	chr14	103986510	103986510	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcacctccgagaacttctCatgcttgcccaggttgggca	9	9	10	13	1	1	1	1	0	1	1	3	2	2	1	3	2	4	4	3	2	2	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:103986510C>T	uc001ynf.1	-	7	996	c.916G>A	c.(916-918)GAG>AAG	p.E306K	CKB_uc001yne.1_Missense_Mutation_p.E128K|CKB_uc010awr.1_Missense_Mutation_p.E237K	NM_001823	NP_001814	P12277	KCRB_HUMAN	brain creatine kinase	306	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity				0		Melanoma(154;0.155)	Epithelial(46;0.14)		Creatine(DB00148)	GAGAACTTCTCATGCTTGCCC	0.632													8	40					0	0	0	0	T	103986510	T	T	103986510	3	4	116	1	0	0	0	0	1	0	0	0	3461	835	29	2	237	2	CKB	14	103986510	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1084991	103986510	3363030	270	20967											
PPP1R13B	23368	broad.mit.edu	37	chr14	104209072	104209072	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgacagacccctccacgctCggatccttccagtctgcacc	7	9	7	18	2	1	2	0	1	1	1	5	3	4	3	6	1	1	2	6	1	0	2	rs12891833		TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:104209072C>T	uc001yof.1	-	10	1522	c.1239G>A	c.(1237-1239)CCG>CCA	p.P413P	PPP1R13B_uc010awv.1_RNA|PPP1R13B_uc001yog.1_Silent_p.P280P	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	413					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				CCTCCACGCTCGGATCCTTCC	0.552													9	69					0	0	0	0	T	104209072	T	T	104209072	2	4	116	1	0	0	0	0	0	0	0	1	12417	871	31	1		1	PPP1R13B	14	104209072	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	222562	104209072	3140468	271	20968											
AHNAK2	113146	broad.mit.edu	37	chr14	105414035	105414035	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggcccttgacatctagctGggggcccttgaggtccattt	5	11	14	11	0	1	2	0	2	1	0	2	2	2	2	3	5	1	1	3	5	1	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:105414035G>A	uc010axc.1	-	7	7873	c.7753C>T	c.(7753-7755)CAG>TAG	p.Q2585*	AHNAK2_uc001ypx.2_Nonsense_Mutation_p.Q2485*	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2585						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACATCTAGCTGGGGGCCCTTG	0.627													67	220					0	0	0	0	A	105414035	A	A	105414035	4	1	116	1	0	0	0	0	0	1	0	0	415	1357	47	4	9638	4	AHNAK2	14	105414035	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1204963	105414035	1935505	272	20969											
BRF1	2972	broad.mit.edu	37	chr14	105677498	105677498	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagggcactgacgcagggctCcccgtcctcctcgtcaggct	5	7	12	17	3	1	1	1	1	0	0	5	1	4	1	4	3	0	4	4	3	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr14:105677498C>T	uc001yqp.2	-	17	2320	c.1957G>A	c.(1957-1959)GAG>AAG	p.E653K	BRF1_uc010tyo.1_Missense_Mutation_p.E538K|BRF1_uc010typ.1_Missense_Mutation_p.E560K|BRF1_uc001yqk.2_Missense_Mutation_p.E179K|BRF1_uc001yql.2_Missense_Mutation_p.E449K|BRF1_uc001yqo.2_Missense_Mutation_p.E415K|BRF1_uc010axg.1_Missense_Mutation_p.E626K|BRF1_uc001yqn.2_Intron|BRF1_uc010axh.1_Intron|BRF1_uc010axi.1_3'UTR	NM_001519	NP_001510	Q92994	TF3B_HUMAN	transcription initiation factor IIIB isoform 1	653					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		ACGCAGGGCTCCCCGTCCTCC	0.667													28	99					0	0	0	0	T	105677498	T	T	105677498	3	4	116	1	0	0	0	0	1	0	0	0	1515	864	30	2	84	2	BRF1	14	105677498	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	263463	105677498	1672042	273	20970											
UBE3A	7337	broad.mit.edu	37	chr15	25620732	25620732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcttggagggatgaggatCacagagttttgcattaatct	10	15	11	5	0	3	2	1	1	2	1	3	5	3	5	0	3	1	2	0	3	1	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:25620732C>T	uc001zaq.2	-	3	250	c.250G>A	c.(250-252)GAT>AAT	p.D84N	UBE3A_uc001zar.2_Missense_Mutation_p.D61N|UBE3A_uc001zas.2_Missense_Mutation_p.D81N|UBE3A_uc001zat.2_Missense_Mutation_p.D61N	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	84					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		GGATGAGGATCACAGAGTTTT	0.423													12	42					0	0	0	0	T	25620732	T	T	25620732	3	4	116	1	0	0	0	0	1	0	0	0	16947	826	29	2	2413	2	UBE3A	15	25620732	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		25620732	76910660	274	20971											
FSIP1	161835	broad.mit.edu	37	chr15	40068622	40068622	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaaggatcctggttctgttGagagcacctccaaagaagca	12	9	11	9	0	1	3	0	2	1	2	3	5	3	4	3	2	2	4	3	2	3	2	rs148913803		TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:40068622G>A	uc001zki.2	-	2	322	c.104C>T	c.(103-105)TCA>TTA	p.S35L		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	35										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		TGGTTCTGTTGAGAGCACCTC	0.388													16	68					0	0	0	0	A	40068622	A	A	40068622	3	1	116	1	0	0	0	0	1	0	0	0	6108	1294	45	2	1685	2	FSIP1	15	40068622	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	14447890	40068622	62462770	275	20972											
INO80	54617	broad.mit.edu	37	chr15	41279293	41279293	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtttagagtacatacgtttCttctccaactcttcgtcgtc	7	16	7	11	3	3	1	0	0	3	1	7	1	3	1	1	1	3	3	1	1	4	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:41279293C>G	uc001zni.2	-	31	4041	c.3828G>C	c.(3826-3828)AAG>AAC	p.K1276N	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1276	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						ACATACGTTTCTTCTCCAACT	0.468													8	22					0	0	0	0	G	41279293	G	G	41279293	3	3	116	1	0	0	0	0	1	0	0	0	7785	912	32	2	866	2	INO80	15	41279293	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1210671	41279293	61252099	276	20973											
MAPKBP1	23005	broad.mit.edu	37	chr15	42109197	42109197	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctacagcagacgctggacGaacactcatcctccatcact	11	7	7	16	2	2	1	2	0	0	1	4	3	4	2	3	1	3	2	3	1	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:42109197G>A	uc001zok.3	+	15	1979	c.1693G>A	c.(1693-1695)GAA>AAA	p.E565K	MAPKBP1_uc001zoj.3_Missense_Mutation_p.E559K|MAPKBP1_uc010bcj.2_Missense_Mutation_p.E66K|MAPKBP1_uc010bci.2_Missense_Mutation_p.E559K|MAPKBP1_uc010udb.1_Missense_Mutation_p.E398K|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Missense_Mutation_p.E66K	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	565	WD 9.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GACGCTGGACGAACACTCATC	0.602													8	110					0	0	0	0	A	42109197	A	A	42109197	3	1	116	1	0	0	0	0	1	0	0	0	9345	1059	37	1	1747	1	MAPKBP1	15	42109197	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	829904	42109197	60422195	277	20974											
SPTBN5	51332	broad.mit.edu	37	chr15	42144929	42144929	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaactccacatctgacactGagtgctggggagaagcatgt	11	8	12	10	0	1	3	0	2	1	1	2	4	2	3	1	2	3	3	1	2	2	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:42144929G>A	uc001zos.2	-	61	10580	c.10247C>T	c.(10246-10248)TCA>TTA	p.S3416L		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3451	Spectrin 31.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		ATCTGACACTGAGTGCTGGGG	0.587													7	218					0	0	0	0	A	42144929	A	A	42144929	3	1	116	1	0	0	0	0	1	0	0	0	15188	1294	45	2	704	2	SPTBN5	15	42144929	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	35732	42144929	60386463	278	20975											
CAPN3	825	broad.mit.edu	37	chr15	42678467	42678467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttcatcgaaaactacgcagGgatcttccacttccaggtga	11	11	8	11	2	2	1	1	1	1	0	5	3	4	2	2	2	2	1	2	2	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:42678467G>A	uc001zpn.1	+	3	788	c.482G>A	c.(481-483)GGG>GAG	p.G161E	CAPN3_uc001zpk.1_5'UTR|CAPN3_uc001zpl.1_Missense_Mutation_p.G74E|CAPN3_uc010udf.1_Missense_Mutation_p.G74E|CAPN3_uc010udg.1_Missense_Mutation_p.G74E|CAPN3_uc001zpo.1_Missense_Mutation_p.G161E|CAPN3_uc001zpp.1_Missense_Mutation_p.G161E	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	161	Calpain catalytic.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		AACTACGCAGGGATCTTCCAC	0.547											OREG0023085	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	95					0	0	0	0	A	42678467	A	A	42678467	3	1	116	1	0	0	0	0	1	0	0	0	2640	1232	43	4	544	4	CAPN3	15	42678467	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	533538	42678467	59852925	279	20976											
STRC	161497	broad.mit.edu	37	chr15	43910158	43910158	+	Frame_Shift_Del	DEL	G	-	-																															atgggggccgagttggggtaGgggggcccccaggaactaag																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:43910158delG	uc001zsf.2	-	2	539	c.461delC	c.(460-462)CCTfs	p.P154fs	STRC_uc010bdl.2_5'UTR|STRC_uc010udz.1_RNA|STRC_uc001zsg.1_Frame_Shift_Del_p.P80fs	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	154					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		AGTTGGGGTAGGGGGGCCCCC	0.642													---	---	---								-	43910158	-	-	43910158	7	5	116	1	0	1	0	1	0	0	0	0	15394	1000	35	0	4978	0	STRC	15	43910158	Frame_Shift_Del	DEL	G	TCGA-CR-5248-01A-01D-2012-08	1231691	43910158	58621234	280	20977											
AP4E1	23431	broad.mit.edu	37	chr15	51226870	51226870	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaatccttacgaagagctGagttaaatcacaatgtcaca	16	10	7	8	1	2	3	2	2	0	1	3	4	3	3	1	0	2	2	1	0	6	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:51226870G>C	uc001zyx.1	+	8	949	c.919G>C	c.(919-921)GAG>CAG	p.E307Q	AP4E1_uc010ufi.1_Missense_Mutation_p.E307Q|AP4E1_uc010ufj.1_RNA|AP4E1_uc010ufk.1_Intron	NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	307					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		ACGAAGAGCTGAGTTAAATCA	0.274													6	22					0	0	0	0	C	51226870	C	C	51226870	3	2	116	1	0	0	0	0	1	0	0	0	752	1291	45	2	949	2	AP4E1	15	51226870	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7316712	51226870	51304522	281	20978											
MYO5A	4644	broad.mit.edu	37	chr15	52620057	52620057	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaggaactgaccttcaataCttttttgatgctgttaattg	11	16	7	7	0	1	2	1	2	0	0	1	3	1	3	1	1	3	2	1	1	4	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:52620057C>G	uc002aby.2	-	35	4871	c.4627G>C	c.(4627-4629)GTA>CTA	p.V1543L	MYO5A_uc002abx.3_Missense_Mutation_p.V1516L|MYO5A_uc010ugd.1_Missense_Mutation_p.V265L	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1543	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		ACCTTCAATACTTTTTTGATG	0.368													26	102					0	0	0	0	G	52620057	G	G	52620057	3	3	116	1	0	0	0	0	1	0	0	0	10131	565	20	4	968	4	MYO5A	15	52620057	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1393187	52620057	49911335	282	20979											
WDR72	256764	broad.mit.edu	37	chr15	53809925	53809925	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttgcaggggcagacctttgCtatccatgaatgatgccttg	8	12	11	10	0	0	3	0	2	0	1	1	3	1	3	3	2	3	3	3	2	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:53809925C>A	uc002acj.2	-	20	3322	c.3280G>T	c.(3280-3282)GCA>TCA	p.A1094S	WDR72_uc010bfh.1_RNA	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	1094										lung(1)|skin(1)	2				all cancers(107;0.0511)		CAGACCTTTGCTATCCATGAA	0.383													6	81					2.0095e-06	2.7548e-06	1	0	A	53809925	A	A	53809925	3	1	116	1	0	0	0	0	1	0	0	0	17390	797	28	4	32	4	WDR72	15	53809925	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1189868	53809925	48721467	283	20980											
GCNT3	9245	broad.mit.edu	37	chr15	59911580	59911580	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagggtgctccttatgctccCtgctctggaatccaccagcg	7	10	10	14	1	1	0	0	0	1	0	4	1	4	1	4	2	4	3	4	2	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:59911580C>G	uc002age.2	+	3	1592	c.1143C>G	c.(1141-1143)CCC>CCG	p.P381P	GCNT3_uc002agd.2_Silent_p.P381P	NM_004751	NP_004742	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin	381	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)	2						CTTATGCTCCCTGCTCTGGAA	0.522													37	122					0	0	0	0	G	59911580	G	G	59911580	2	3	116	1	0	0	0	0	0	0	0	1	6337	668	24	4		4	GCNT3	15	59911580	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	6101655	59911580	42619812	284	20981											
MTFMT	123263	broad.mit.edu	37	chr15	65316055	65316055	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttactccagtaactgtgtctCcgtgaagcactgtatggatt	9	14	9	9	1	1	1	0	1	1	0	3	2	2	2	2	1	3	3	2	1	4	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:65316055C>T	uc002aof.3	-	3	523	c.497G>A	c.(496-498)GGA>GAA	p.G166E		NM_139242	NP_640335	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	166						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			ovary(2)	2					Tetrahydrofolic acid(DB00116)	AACTGTGTCTCCGTGAAGCAC	0.398													6	27					0	0	0	0	T	65316055	T	T	65316055	3	4	116	1	0	0	0	0	1	0	0	0	9977	855	30	2	700	2	MTFMT	15	65316055	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	5404475	65316055	37215337	285	20982											
CYP11A1	1583	broad.mit.edu	37	chr15	74659879	74659879	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggggcactcagaaaggtctgGcagcctttgaccaggactga	10	7	14	10	0	2	3	1	2	1	1	2	4	2	4	2	5	1	2	2	5	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:74659879G>T	uc002axt.2	-	1	203	c.48C>A	c.(46-48)TGC>TGA	p.C16*	CYP11A1_uc002axs.2_5'Flank|CYP11A1_uc010bjm.1_5'Flank|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Nonsense_Mutation_p.C16*|CYP11A1_uc010ulj.1_5'UTR|CYP11A1_uc010bjq.2_Nonsense_Mutation_p.C16*	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	16				C -> Y (in Ref. 1; AAA52162).	C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	GAAAGGTCTGGCAGCCTTTGA	0.652													6	39					3.59834e-05	4.8757e-05	1	0	T	74659879	T	T	74659879	4	4	116	1	0	0	0	0	0	1	0	0	4161	1195	42	4	1553	4	CYP11A1	15	74659879	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	9343824	74659879	27871513	286	20983											
FANCI	55215	broad.mit.edu	37	chr15	89802003	89802003	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcactcctgagagccatcttCaaaggtaataataattaatg	15	11	7	8	0	2	1	1	1	1	1	3	2	3	1	2	1	1	2	2	1	5	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:89802003C>T	uc010bnp.1	+	3	243	c.153C>T	c.(151-153)TTC>TTT	p.F51F	FANCI_uc002bnm.1_Silent_p.F51F|FANCI_uc002bnn.1_RNA|FANCI_uc002bno.2_Silent_p.F51F	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	51					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					GAGCCATCTTCAAAGGTAATA	0.398								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				14	93					0	0	0	0	T	89802003	T	T	89802003	2	4	116	1	0	0	0	0	0	0	0	1	5701	825	29	2		2	FANCI	15	89802003	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	15142124	89802003	12729389	287	20984											
C15orf42	90381	broad.mit.edu	37	chr15	90135363	90135363	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggaaaagtggtttcctttCtgtaacatcagtggtgccag	9	13	12	7	0	2	0	1	0	1	0	3	1	3	1	2	3	2	2	2	3	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:90135363C>G	uc002boe.2	+	5	1497	c.1497C>G	c.(1495-1497)TTC>TTG	p.F499L		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	499					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GGTTTCCTTTCTGTAACATCA	0.443													3	45					0	0	0	0	G	90135363	G	G	90135363	3	3	116	1	0	0	0	0	1	0	0	0	1802	912	32	2	1515	2	C15orf42	15	90135363	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	333360	90135363	12396029	288	20985											
LRRC28	123355	broad.mit.edu	37	chr15	99903443	99903443	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagctctttcccttgagagAgacgccaatggcagggctgc	9	8	12	12	1	1	2	0	1	1	2	2	4	2	2	2	2	2	3	2	2	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr15:99903443A>T	uc002bva.1	+	9	1159	c.1004A>T	c.(1003-1005)GAG>GTG	p.E335V	LRRC28_uc010urs.1_RNA|LRRC28_uc002bvb.1_Missense_Mutation_p.E181V|LRRC28_uc010urt.1_Missense_Mutation_p.E149V|LRRC28_uc002bvc.1_Intron|LRRC28_uc010uru.1_Missense_Mutation_p.E266V|LRRC28_uc002bvd.1_Intron	NM_144598	NP_653199	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	335											0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			CCCTTGAGAGAGACGCCAATG	0.582													7	71					0	0	0	0	T	99903443	T	T	99903443	3	4	116	1	0	0	0	0	1	0	0	0	9032	304	11	5	1034	5	LRRC28	15	99903443	Missense_Mutation	SNP	A	TCGA-CR-5248-01A-01D-2012-08	9768080	99903443	2627949	289	20986											
SOLH	6650	broad.mit.edu	37	chr16	597026	597026	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caacttcctgggcaaggaggCctgcgaggtgtgcggcttca	7	8	15	11	2	1	0	1	0	0	0	2	2	2	1	2	5	3	2	2	5	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:597026C>T	uc002chi.2	+	4	551	c.188C>T	c.(187-189)GCC>GTC	p.A63V	SOLH_uc002chh.1_Missense_Mutation_p.A63V	NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	63	RanBP2-type 2.				proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				GGCAAGGAGGCCTGCGAGGTG	0.692													5	25					0	0	0	0	T	597026	T	T	597026	3	4	116	1	0	0	0	0	1	0	0	0	14989	739	26	4	190	4	SOLH	16	597026	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		597026	89757727	290	20987											
ZNF174	7727	broad.mit.edu	37	chr16	3452340	3452340	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcaggcatcgatgtccaatGagcagcaaggagattgtgac	12	8	13	8	1	1	3	1	2	0	1	3	5	2	3	1	2	2	3	1	2	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:3452340G>C	uc002cvc.2	+	1	1151	c.336G>C	c.(334-336)ATG>ATC	p.M112I	ZNF434_uc002cux.3_5'Flank|ZNF434_uc010uwx.1_5'Flank|ZNF434_uc002cuy.3_5'Flank|ZNF434_uc002cuz.2_5'Flank|ZNF434_uc010uwy.1_5'Flank|ZNF434_uc010uxa.1_5'Flank|ZNF174_uc002cva.2_Missense_Mutation_p.M112I|ZNF174_uc002cvb.2_Missense_Mutation_p.M112I	NM_003450	NP_003441	Q15697	ZN174_HUMAN	zinc finger protein 174 isoform a	112	SCAN box.				negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0						GATGTCCAATGAGCAGCAAGG	0.542													19	57					0	0	0	0	C	3452340	C	C	3452340	3	2	116	1	0	0	0	0	1	0	0	0	17811	1290	45	2	338	2	ZNF174	16	3452340	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2855314	3452340	86902413	291	20988											
PRM2	5620	broad.mit.edu	37	chr16	11370049	11370049	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggatccggtgcagcctccttCgagagcagtgtctgcgccta	6	9	13	13	3	1	1	0	0	1	1	4	3	3	2	4	2	4	2	4	2	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:11370049C>T	uc002dau.1	-	1	289	c.179G>A	c.(178-180)CGA>CAA	p.R60Q	C16orf75_uc002daq.1_Intron|PRM3_uc002dat.1_5'Flank|PRM2_uc010bus.1_Missense_Mutation_p.R60Q	NM_002762	NP_002753	P04554	PRM2_HUMAN	protamine 2	60					chromosome condensation|multicellular organismal development	nucleoplasm|nucleosome	DNA binding				0						CAGCCTCCTTCGAGAGCAGTG	0.642													25	76					0	0	0	0	T	11370049	T	T	11370049	3	4	116	1	0	0	0	0	1	0	0	0	12595	884	31	1	137	1	PRM2	16	11370049	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	7917709	11370049	78984704	292	20989											
ABCC6	368	broad.mit.edu	37	chr16	16255391	16255391	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctgcaaacaccaggccattCcccaggagctccacattggc	10	6	9	16	0	0	0	0	0	0	0	2	1	2	1	5	3	3	3	5	3	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:16255391C>T	uc002den.3	-	25	3574	c.3537G>A	c.(3535-3537)GGG>GGA	p.G1179G	ABCC6_uc010bvo.2_RNA	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	1179	Helical; Name=16; (By similarity).|ABC transmembrane type-1 2.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CCAGGCCATTCCCCAGGAGCT	0.602													9	54					0	0	0	0	T	16255391	T	T	16255391	2	4	116	1	0	0	0	0	0	0	0	1	57	842	30	2		2	ABCC6	16	16255391	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	4885342	16255391	74099362	293	20990											
ERN2	10595	broad.mit.edu	37	chr16	23706160	23706160	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagcaggcagcttcttgcaGaggccgaagtctgagagcac	10	6	13	12	1	2	2	0	1	2	2	2	4	2	2	2	2	4	5	2	2	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:23706160G>A	uc002dma.3	-	17	2302	c.2133C>T	c.(2131-2133)CTC>CTT	p.L711L	ERN2_uc010bxp.2_Silent_p.L659L	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	663	Protein kinase.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GCTTCTTGCAGAGGCCGAAGT	0.647													10	31					0	0	0	0	A	23706160	A	A	23706160	2	1	116	1	0	0	0	0	0	0	0	1	5262	929	33	2		2	ERN2	16	23706160	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7450769	23706160	66648593	294	20991											
GTF3C1	2975	broad.mit.edu	37	chr16	27480793	27480793	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcaggtttcacctccatgctCcggcgcttgccccctacacc	5	9	8	19	2	1	0	1	0	0	0	3	0	3	0	6	2	3	4	6	2	1	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:27480793C>G	uc002dov.1	-	32	4933	c.4893G>C	c.(4891-4893)CGG>CGC	p.R1631R	GTF3C1_uc002dou.2_Silent_p.R1631R	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1631						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CCTCCATGCTCCGGCGCTTGC	0.602													15	53					0	0	0	0	G	27480793	G	G	27480793	2	3	116	1	0	0	0	0	0	0	0	1	6911	842	30	2		2	GTF3C1	16	27480793	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3774633	27480793	62873960	295	20992											
ZNF629	23361	broad.mit.edu	37	chr16	30794731	30794731	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgtggatcttctggtgcttGaggaggttgtggttctggcc	3	14	17	7	1	3	1	0	1	3	0	3	3	3	3	1	6	1	3	1	6	0	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:30794731G>A	uc002dzs.1	-	3	1126	c.918C>T	c.(916-918)CTC>CTT	p.L306L		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	306	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			TCTGGTGCTTGAGGAGGTTGT	0.642													18	95					0	0	0	0	A	30794731	A	A	30794731	2	1	116	1	0	0	0	0	0	0	0	1	18120	1277	45	2		2	ZNF629	16	30794731	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3313938	30794731	59560022	296	20993											
CNOT1	23019	broad.mit.edu	37	chr16	58577583	58577583	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggttccctgcatgtaatCatagccattccagctgtcaa	12	11	7	11	0	2	0	2	0	0	0	4	0	4	0	3	1	3	4	3	1	4	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:58577583C>A	uc002env.2	-	31	4655	c.4362G>T	c.(4360-4362)ATG>ATT	p.M1454I	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.M1449I|CNOT1_uc002enx.2_Missense_Mutation_p.M1454I|CNOT1_uc010vik.1_Missense_Mutation_p.M411I	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1454					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TGCATGTAATCATAGCCATTC	0.438													11	27					6.40141e-05	8.65376e-05	1	0	A	58577583	A	A	58577583	3	1	116	1	0	0	0	0	1	0	0	0	3632	826	29	2	3066	2	CNOT1	16	58577583	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	27782852	58577583	31777170	297	20994											
CDH3	1001	broad.mit.edu	37	chr16	68712542	68712542	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ataagccactggaccgggagGagattgccaagtatgaggca	13	6	14	8	1	0	2	0	1	0	1	0	5	0	4	3	4	2	2	3	4	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:68712542G>T	uc002ewf.2	+	5	1661	c.529G>T	c.(529-531)GAG>TAG	p.E177*	CDH3_uc010vli.1_Nonsense_Mutation_p.E122*	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	177	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		GGACCGGGAGGAGATTGCCAA	0.582													17	83					2.48551e-13	3.52314e-13	1	0	T	68712542	T	T	68712542	4	4	116	1	0	0	0	0	0	1	0	0	3126	1175	41	2	547	2	CDH3	16	68712542	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	10134959	68712542	21642211	298	20995											
TMCO7	79613	broad.mit.edu	37	chr16	68877575	68877575	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggagacatgcggtctggatCggattttggaggcattgaag	10	10	16	5	2	1	2	0	1	1	1	2	6	1	5	0	6	1	1	0	6	1	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:68877575C>T	uc002ewi.3	+	1	67	c.55C>T	c.(55-57)CGG>TGG	p.R19W	TMCO7_uc002ewh.2_Missense_Mutation_p.R19W	NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	19						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		CGGTCTGGATCGGATTTTGGA	0.697													15	131					0	0	0	0	T	68877575	T	T	68877575	3	4	116	1	0	0	0	0	1	0	0	0	16067	875	31	1	57	1	TMCO7	16	68877575	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	165033	68877575	21477178	299	20996											
ZC3H18	124245	broad.mit.edu	37	chr16	88665043	88665043	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatagggtgggccggtagttGatgaaattttgcctccaccc	9	11	12	9	1	0	2	0	2	0	0	1	2	1	2	4	3	1	2	4	3	4	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:88665043G>A	uc002fky.2	+	5	1053	c.853G>A	c.(853-855)GAT>AAT	p.D285N	ZC3H18_uc010voy.1_Missense_Mutation_p.D168N|ZC3H18_uc010voz.1_Missense_Mutation_p.D309N	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	285	Pro-rich.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		GCCGGTAGTTGATGAAATTTT	0.468													5	13					0	0	0	0	A	88665043	A	A	88665043	3	1	116	1	0	0	0	0	1	0	0	0	17635	1290	45	2	867	2	ZC3H18	16	88665043	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	19787468	88665043	1689710	300	20997											
ANKRD11	29123	broad.mit.edu	37	chr16	89352507	89352508	+	Frame_Shift_Ins	INS	-	G	G																															aacaggaggttcaccatcgtINSgggggagttggccactttca																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr16:89352507_89352508insG	uc002fmx.1	-	8	1292_1293	c.831_832insC	c.(829-834)CCCACGfs	p.P277fs	ANKRD11_uc002fmy.1_Frame_Shift_Ins_p.P277fs|ANKRD11_uc002fnc.1_Frame_Shift_Ins_p.P277fs|ANKRD11_uc002fnb.1_Frame_Shift_Ins_p.P234fs	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	277_278	ANK 4.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTCACCATCGTGGGGGAGTTGG	0.574													---	---	---								G	89352508	G	G	89352507	7	5	116	1	0	1	1	0	0	0	0	0	639	1696	59	0	7183	0	ANKRD11	16	89352507	Frame_Shift_Ins	INS	-	TCGA-CR-5248-01A-01D-2012-08	687464	89352507	1002246	301	20998											
VPS53	55275	broad.mit.edu	37	chr17	530477	530477	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accactcacgtggaaacatgCggccgtatttctcctcatag	10	10	8	13	3	3	0	2	0	1	0	4	1	3	1	3	2	2	1	3	2	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:530477C>T	uc002frn.2	-	10	1058	c.911G>A	c.(910-912)CGC>CAC	p.R304H	VPS53_uc002frk.2_5'UTR|VPS53_uc010cjo.1_Missense_Mutation_p.R304H|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Missense_Mutation_p.R275H|VPS53_uc002fro.2_Missense_Mutation_p.R106H|VPS53_uc010cjp.1_Intron	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	304					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		TGGAAACATGCGGCCGTATTT	0.498													20	53					0	0	0	0	T	530477	T	T	530477	3	4	116	1	0	0	0	0	1	0	0	0	17283	768	27	1	1654	1	VPS53	17	530477	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		530477	80664733	302	20999											
ABR	29	broad.mit.edu	37	chr17	1028559	1028559	+	Frame_Shift_Del	DEL	C	-	-																															tggagtcggggagacgccatCccccccgccctggctgcggg																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:1028559delC	uc002fsd.2	-	2	315	c.205delG	c.(205-207)GATfs	p.D69fs	ABR_uc002fse.2_Frame_Shift_Del_p.D23fs|ABR_uc010cjq.1_Frame_Shift_Del_p.D81fs	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	69					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		GAGACGCCATCCCCCCCGCCC	0.677													---	---	---								-	1028559	-	-	1028559	7	5	116	1	0	1	0	1	0	0	0	0	99	855	30	0	2601	0	ABR	17	1028559	Frame_Shift_Del	DEL	C	TCGA-CR-5248-01A-01D-2012-08	498082	1028559	80166651	303	21000											
SLC25A11	8402	broad.mit.edu	37	chr17	4843164	4843164	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttaggggaggtacggggcttCccgtctatcccgccggcccc	4	8	14	15	4	1	0	0	0	1	0	3	1	3	1	5	6	1	2	5	6	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:4843164C>A	uc002fzo.1	-	1	155	c.42G>T	c.(40-42)GGG>GGT	p.G14G	SLC25A11_uc002fzp.1_5'UTR|RNF167_uc002fzq.2_5'Flank|RNF167_uc002fzr.2_5'Flank|RNF167_uc002fzs.2_5'Flank|RNF167_uc002fzt.2_5'Flank|RNF167_uc002fzu.2_5'Flank|RNF167_uc002fzv.2_5'Flank|RNF167_uc002fzw.1_5'Flank|RNF167_uc002fzx.2_5'Flank	NM_003562	NP_003553	Q02978	M2OM_HUMAN	solute carrier family 25 member 11 isoform 1	14					gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity				0						TACGGGGCTTCCCGTCTATCC	0.706													4	25					1.23904e-05	1.68671e-05	1	0	A	4843164	A	A	4843164	2	1	116	1	0	0	0	0	0	0	0	1	14537	842	30	2		2	SLC25A11	17	4843164	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3814605	4843164	76352046	304	21001											
C17orf74	201243	broad.mit.edu	37	chr17	7330298	7330298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccccctgcctcggtgtccCggaacgcccggcctgaggcc	3	5	13	20	4	0	1	0	1	0	0	2	2	1	2	8	4	2	0	8	4	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:7330298C>T	uc002ggw.2	+	3	1061	c.988C>T	c.(988-990)CGG>TGG	p.R330W	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	330						integral to membrane					0		Prostate(122;0.157)				CTCGGTGTCCCGGAACGCCCG	0.692													16	37					0	0	0	0	T	7330298	T	T	7330298	3	4	116	1	0	0	0	0	1	0	0	0	1887	643	23	1	998	1	C17orf74	17	7330298	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2487134	7330298	73864912	305	21002											
DNAH9	1770	broad.mit.edu	37	chr17	11584154	11584154	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gccagaggtgcacagccttcGatgcagaacagcagcaattc	12	6	11	12	1	0	2	0	0	0	2	2	3	0	2	2	1	6	4	2	1	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:11584154G>C	uc002gne.2	+	19	3759	c.3691G>C	c.(3691-3693)GAT>CAT	p.D1231H	DNAH9_uc010coo.2_Missense_Mutation_p.D525H	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1231	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CACAGCCTTCGATGCAGAACA	0.522													9	24					0	0	0	0	C	11584154	C	C	11584154	3	2	116	1	0	0	0	0	1	0	0	0	4630	1058	37	3	3765	3	DNAH9	17	11584154	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	4253856	11584154	69611056	306	21003											
RASD1	51655	broad.mit.edu	37	chr17	17399349	17399349	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtaggcgtgtaggcgtcctcGaagcggccggtgaggaagcg	7	6	19	9	6	0	1	0	1	0	0	2	3	1	2	2	5	2	2	2	5	4	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:17399349G>A	uc002gri.2	-	1	359	c.147C>T	c.(145-147)TTC>TTT	p.F49F		NM_016084	NP_057168	Q9Y272	RASD1_HUMAN	RAS, dexamethasone-induced 1 precursor	49					G-protein coupled receptor protein signaling pathway|small GTPase mediated signal transduction	nucleus|perinuclear region of cytoplasm|plasma membrane	GTP binding|GTPase activity				0						AGGCGTCCTCGAAGCGGCCGG	0.622													16	52					0	0	0	0	A	17399349	A	A	17399349	2	1	116	1	0	0	0	0	0	0	0	1	13131	1049	37	1		1	RASD1	17	17399349	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	5815195	17399349	63795861	307	21004											
CCDC144B	284047	broad.mit.edu	37	chr17	18525853	18525853	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactttcaggtgtctgttttTccttatattcaggaactagt	8	18	8	7	0	3	0	2	0	1	0	4	2	4	1	1	2	1	1	1	2	4	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:18525853T>C	uc002gub.1	-	2	459	c.374A>G	c.(373-375)GAA>GGA	p.E125G	CCDC144B_uc002gua.3_RNA|CCDC144B_uc010vyc.1_RNA|CCDC144B_uc002guc.1_Missense_Mutation_p.E125G	NM_182568	NP_872374			coiled-coil domain containing 144B											ovary(1)|skin(1)	2						TGTCTGTTTTTCCTTATATTC	0.274													15	19					0	0	0	0	C	18525853	C	C	18525853	3	2	116	1	0	0	0	0	1	0	0	0	2790	1783	62	5	1838	5	CCDC144B	17	18525853	Missense_Mutation	SNP	T	TCGA-CR-5248-01A-01D-2012-08	1126504	18525853	62669357	308	21005											
FAM83G	644815	broad.mit.edu	37	chr17	18881970	18881970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcttggccacagtgcccgCgggcaccagggggaccacag	7	5	14	15	2	1	0	0	0	1	0	1	1	1	1	4	4	1	1	4	4	0	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:18881970C>T	uc002guw.2	-	5	1176	c.1009G>A	c.(1009-1011)GCG>ACG	p.A337T	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	337										ovary(1)|central_nervous_system(1)	2						ACAGTGCCCGCGGGCACCAGG	0.597													40	148					0	0	0	0	T	18881970	T	T	18881970	3	4	116	1	0	0	0	0	1	0	0	0	5671	768	27	1	1470	1	FAM83G	17	18881970	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	356117	18881970	62313240	309	21006											
SARM1	23098	broad.mit.edu	37	chr17	26711532	26711532	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcccagctggaaggaggccGaggttcagacgtggctgcag	8	6	17	10	2	1	1	1	0	0	1	1	4	1	3	2	5	3	4	2	5	1	1	rs147156050	byFrequency	TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:26711532G>A	uc010crl.1	+	6	1313	c.1246G>A	c.(1246-1248)GAG>AAG	p.E416K	SARM1_uc010waj.1_RNA|SARM1_uc002hbe.1_5'Flank	NM_015077	NP_055892	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	416	SAM 1.				innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		GAAGGAGGCCGAGGTTCAGAC	0.677													7	30					0	0	0	0	A	26711532	A	A	26711532	3	1	116	1	0	0	0	0	1	0	0	0	13907	1059	37	1	1254	1	SARM1	17	26711532	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7829562	26711532	54483678	310	21007											
SARM1	23098	broad.mit.edu	37	chr17	26711577	26711577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcggtttctccaagtactgcGagagcttccgggtagagtcg	7	11	13	10	4	1	2	0	0	1	2	5	3	2	2	2	2	3	4	2	2	3	4	rs137938585	by1000genomes	TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:26711577G>A	uc010crl.1	+	6	1358	c.1291G>A	c.(1291-1293)GAG>AAG	p.E431K	SARM1_uc010waj.1_RNA|SARM1_uc002hbe.1_5'Flank	NM_015077	NP_055892	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	431	SAM 1.				innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CAAGTACTGCGAGAGCTTCCG	0.682													6	18					0	0	0	0	A	26711577	A	A	26711577	3	1	116	1	0	0	0	0	1	0	0	0	13907	1059	37	1	1299	1	SARM1	17	26711577	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	45	26711577	54483633	311	21008											
LRRC37B	114659	broad.mit.edu	37	chr17	30349151	30349151	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagtgacagttcaacctcCaggtgaggatcaagctcatt	12	10	10	9	0	3	3	3	3	0	0	4	4	4	4	2	2	2	2	2	2	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:30349151C>G	uc002hgu.2	+	1	997	c.986C>G	c.(985-987)CCA>CGA	p.P329R	LRRC37B_uc010wbx.1_Missense_Mutation_p.P247R|LRRC37B_uc010csu.2_Missense_Mutation_p.P329R	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	329	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				GTTCAACCTCCAGGTGAGGAT	0.473													34	132					0	0	0	0	G	30349151	G	G	30349151	3	3	116	1	0	0	0	0	1	0	0	0	9044	594	21	4	988	4	LRRC37B	17	30349151	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3637574	30349151	50846059	312	21009											
SLFN12	55106	broad.mit.edu	37	chr17	33738501	33738501	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggctttaaaaagggctttCagcaagtatttccttcttgt	11	15	8	7	0	2	0	1	0	1	0	3	0	3	0	1	2	1	4	1	2	6	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:33738501C>T	uc002hji.3	-	4	1970	c.1593G>A	c.(1591-1593)CTG>CTA	p.L531L	SLFN12_uc002hjj.3_Silent_p.L531L|SLFN12_uc010cts.2_Silent_p.L531L	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	531							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AAAGGGCTTTCAGCAAGTATT	0.388													15	60					0	0	0	0	T	33738501	T	T	33738501	2	4	116	1	0	0	0	0	0	0	0	1	14798	813	29	2		2	SLFN12	17	33738501	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3389350	33738501	47456709	313	21010											
GPR179	440435	broad.mit.edu	37	chr17	36486166	36486166	+	Frame_Shift_Del	DEL	G	-	-																															tctgtaggtgctccgagaacGggtcagagctttaatcgcca																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:36486166delG	uc002hpz.2	-	11	3307	c.3286delC	c.(3286-3288)CGTfs	p.R1096fs		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1096	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CTCCGAGAACGGGTCAGAGCT	0.612													---	---	---								-	36486166	-	-	36486166	7	5	116	1	0	1	0	1	0	0	0	0	6712	1116	39	0	3821	0	GPR179	17	36486166	Frame_Shift_Del	DEL	G	TCGA-CR-5248-01A-01D-2012-08	2747665	36486166	44709044	314	21011											
GSDMB	55876	broad.mit.edu	37	chr17	38066128	38066128	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcaccagatacaggttttCtctcgtattaattgatcgga	10	15	8	8	2	2	2	1	1	1	1	5	3	2	3	1	2	1	2	1	2	3	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:38066128C>G	uc010cwj.2	-	3	462	c.457G>C	c.(457-459)GAA>CAA	p.E153Q	GSDMB_uc010cwi.2_5'Flank|GSDMB_uc010cwk.2_RNA|GSDMB_uc010cwl.2_RNA|GSDMB_uc010cwm.2_Intron|GSDMB_uc002htg.2_Missense_Mutation_p.E153Q|GSDMB_uc002hth.2_Missense_Mutation_p.E153Q|GSDMB_uc010wem.1_Missense_Mutation_p.E153Q	NM_001042471	NP_001035936	Q8TAX9	GSDMB_HUMAN	gasdermin B isoform 1	153						cytoplasm				breast(1)|pancreas(1)	2						TACAGGTTTTCTCTCGTATTA	0.473													20	60					0	0	0	0	G	38066128	G	G	38066128	3	3	116	1	0	0	0	0	1	0	0	0	6856	922	32	2	825	2	GSDMB	17	38066128	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1579962	38066128	43129082	315	21012											
DGKE	8526	broad.mit.edu	37	chr17	54912414	54912414	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacattctgcagggcgccttCtgcgactgctgcgggctccg	4	9	13	15	4	2	0	0	0	2	0	3	1	3	0	2	2	4	3	2	2	0	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:54912414C>G	uc002iur.2	+	2	438	c.258C>G	c.(256-258)TTC>TTG	p.F86L	DGKE_uc002ius.1_Missense_Mutation_p.F86L|C17orf67_uc002iuq.2_5'Flank	NM_003647	NP_003638	P52429	DGKE_HUMAN	diacylglycerol kinase epsilon	86	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)					AGGGCGCCTTCTGCGACTGCT	0.627													11	43					0	0	0	0	G	54912414	G	G	54912414	3	3	116	1	0	0	0	0	1	0	0	0	4490	912	32	2	260	2	DGKE	17	54912414	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	16846286	54912414	26282796	316	21013											
SCPEP1	59342	broad.mit.edu	37	chr17	55075841	55075841	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagctcaaaattattcctGaggatcaatcctggggaggt	13	10	11	7	0	2	2	2	1	0	1	4	4	4	4	2	4	1	1	2	4	5	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:55075841G>T	uc002iuv.3	+	10	1029	c.976G>T	c.(976-978)GAG>TAG	p.E326*	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Nonsense_Mutation_p.E276*	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	326					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					AATTATTCCTGAGGATCAATC	0.438													23	59					5.35356e-11	7.51557e-11	1	0	T	55075841	T	T	55075841	4	4	116	1	0	0	0	0	0	1	0	0	14000	1291	45	2	1014	2	SCPEP1	17	55075841	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	163427	55075841	26119369	317	21014											
EPX	8288	broad.mit.edu	37	chr17	56276417	56276417	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaggtgacacccgatcaacGgaaacccccaaactggcagc	14	3	9	15	2	1	1	1	1	0	0	1	3	1	2	3	3	4	1	3	3	4	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:56276417G>A	uc002ivq.2	+	8	1223	c.1137G>A	c.(1135-1137)ACG>ACA	p.T379T		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	379					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						CCCGATCAACGGAAACCCCCA	0.567													8	20					0	0	0	0	A	56276417	A	A	56276417	2	1	116	1	0	0	0	0	0	0	0	1	5224	1103	39	1		1	EPX	17	56276417	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1200576	56276417	24918793	318	21015											
BZRAP1	9256	broad.mit.edu	37	chr17	56403660	56403660	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcctttcctcaccaccctCaggttcgtttcctgcagctt	4	14	5	18	1	2	0	2	0	0	0	6	0	5	0	6	1	2	4	6	1	0	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:56403660C>T	uc002ivx.3	-	3	1435	c.564G>A	c.(562-564)CTG>CTA	p.L188L	BZRAP1_uc010dcs.2_Silent_p.L188L|BZRAP1_uc010wnt.1_Silent_p.L188L|uc010dct.1_5'Flank|uc010dcu.1_5'Flank	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	188						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCACCACCCTCAGGTTCGTTT	0.637													23	48					0	0	0	0	T	56403660	T	T	56403660	2	4	116	1	0	0	0	0	0	0	0	1	1582	813	29	2		2	BZRAP1	17	56403660	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	127243	56403660	24791550	319	21016											
BRIP1	83990	broad.mit.edu	37	chr17	59885908	59885908	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggatggacacaagtatgatCcctgctggaaagaatagtca	15	8	11	7	0	1	2	1	1	0	1	2	5	2	5	1	3	1	2	1	3	5	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:59885908C>T	uc002izk.1	-	7	979	c.838G>A	c.(838-840)GAT>AAT	p.D280N		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	280	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						CAAGTATGATCCCTGCTGGAA	0.438			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				16	64					0	0	0	0	T	59885908	T	T	59885908	3	4	116	1	0	0	0	0	1	0	0	0	1519	855	30	2	2967	2	BRIP1	17	59885908	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	3482248	59885908	21309302	320	21017											
FDXR	2232	broad.mit.edu	37	chr17	72860147	72860147	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagcccacaagggaggtcttCcatgtctcccgtgggcactg	7	8	12	14	1	2	0	0	0	2	0	4	1	3	1	3	3	1	1	3	3	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:72860147C>G	uc002jly.2	-	10	1132	c.1045G>C	c.(1045-1047)GAA>CAA	p.E349Q	FDXR_uc010wri.1_Missense_Mutation_p.E297Q|FDXR_uc010wrj.1_Missense_Mutation_p.E347Q|FDXR_uc002jlw.2_Missense_Mutation_p.E106Q|FDXR_uc002jlx.2_Missense_Mutation_p.E355Q|FDXR_uc002jmc.2_Missense_Mutation_p.E321Q|FDXR_uc010wrk.1_Missense_Mutation_p.E380Q|FDXR_uc010wrl.1_Missense_Mutation_p.E392Q|FDXR_uc002jma.2_Missense_Mutation_p.E350Q|FDXR_uc010wrm.1_Missense_Mutation_p.E309Q|FDXR_uc002jlz.2_Missense_Mutation_p.E341Q|FDXR_uc002jmb.2_Intron	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	349					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					GGGAGGTCTTCCATGTCTCCC	0.632													8	75					0	0	0	0	G	72860147	G	G	72860147	3	3	116	1	0	0	0	0	1	0	0	0	5839	864	30	2	442	2	FDXR	17	72860147	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	12974239	72860147	8335063	321	21018											
ZACN	353174	broad.mit.edu	37	chr17	74077661	74077661	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acggcgctcaagtccatcatCgctctcttggtgcctgcaga	7	10	10	14	3	3	1	2	0	1	1	6	1	4	1	2	2	2	3	2	2	1	1	rs143332874		TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr17:74077661C>T	uc002jqn.2	+	7	788	c.705C>T	c.(703-705)ATC>ATT	p.I235I	ZACN_uc002jqo.2_RNA|ZACN_uc010dgu.2_Intron|EXOC7_uc002jqp.1_3'UTR|EXOC7_uc010dgv.1_3'UTR|EXOC7_uc002jqs.2_3'UTR|EXOC7_uc002jqq.2_3'UTR|EXOC7_uc010wsw.1_3'UTR|EXOC7_uc010wsx.1_3'UTR|EXOC7_uc002jqr.2_3'UTR|EXOC7_uc010wsv.1_3'UTR	NM_180990	NP_851321	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	235	Leu-rich.|Helical; Name=1; (Potential).				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity				0						AGTCCATCATCGCTCTCTTGG	0.642													31	98					0	0	0	0	T	74077661	T	T	74077661	2	4	116	1	0	0	0	0	0	0	0	1	17578	874	31	1		1	ZACN	17	74077661	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1217514	74077661	7117549	322	21019											
NDC80	10403	broad.mit.edu	37	chr18	2578095	2578096	+	Frame_Shift_Del	DEL	AC	-	-																															cccctcatacgaacttcctgAcacaaagtttgaagaagagg																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr18:2578095_2578096delAC	uc002kli.2	+	5	613_614	c.431_432delAC	c.(430-432)GACfs	p.D144fs		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	144	Interaction with the N-terminus of CDCA1.|Nuclear localization.|Interaction with RB1.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						GAACTTCCTGACACAAAGTTTG	0.386													---	---	---								-	2578096	-	-	2578095	7	5	116	1	0	1	0	1	0	0	0	0	10296	275	10	0	445	0	NDC80	18	2578095	Frame_Shift_Del	DEL	AC	TCGA-CR-5248-01A-01D-2012-08		2578095	75499153	323	21020											
PTPN2	5771	broad.mit.edu	37	chr18	12814324	12814325	+	Frame_Shift_Ins	INS	-	T	T																															ctcatgttcagtaacacttgINSttttatgttaatatcatctc																										TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr18:12814324_12814325insT	uc002krp.2	-	7	929_930	c.735_736insA	c.(733-738)AAACAAfs	p.K245fs	PTPN2_uc002krl.2_Frame_Shift_Ins_p.K245fs|PTPN2_uc002krn.2_Frame_Shift_Ins_p.K268fs|PTPN2_uc002kro.2_Frame_Shift_Ins_p.K245fs|PTPN2_uc002krm.2_Frame_Shift_Ins_p.K245fs	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	245_246	Tyrosine-protein phosphatase.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)				AGTAACACTTGTTTTATGTTAA	0.356													---	---	---								T	12814325	T	T	12814324	7	5	116	1	0	1	1	0	0	0	0	0	12848	1386	48	0	549	0	PTPN2	18	12814324	Frame_Shift_Ins	INS	-	TCGA-CR-5248-01A-01D-2012-08	10236229	12814324	65262924	324	21021											
ZNF521	25925	broad.mit.edu	37	chr18	22805237	22805237	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcagccgtacataggctcaGaggtgtcaacgtcttcttcg	8	10	11	12	4	4	1	2	0	2	1	5	1	4	1	1	2	3	3	1	2	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr18:22805237G>C	uc002kvk.2	-	4	2892	c.2645C>G	c.(2644-2646)TCT>TGT	p.S882C	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.S882C|ZNF521_uc002kvl.2_Missense_Mutation_p.S662C	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	882					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CATAGGCTCAGAGGTGTCAAC	0.532			T	PAX5	ALL								18	69					0	0	0	0	C	22805237	C	C	22805237	3	2	116	1	0	0	0	0	1	0	0	0	18032	942	33	2	1310	2	ZNF521	18	22805237	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	9990913	22805237	55272011	325	21022											
ASXL3	80816	broad.mit.edu	37	chr18	31320039	31320039	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcttttctgaagggacaGataataagggaaatgagctt	13	12	11	5	0	2	3	0	2	2	1	2	5	2	5	0	2	1	1	0	2	4	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr18:31320039G>A	uc010dmg.1	+	11	2726	c.2671G>A	c.(2671-2673)GAT>AAT	p.D891N	ASXL3_uc002kxq.2_Missense_Mutation_p.D598N	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	891					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TGAAGGGACAGATAATAAGGG	0.348													9	53					0	0	0	0	A	31320039	A	A	31320039	3	1	116	1	0	0	0	0	1	0	0	0	1070	942	33	2	2713	2	ASXL3	18	31320039	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	8514802	31320039	46757209	326	21023											
ZNF396	252884	broad.mit.edu	37	chr18	32954025	32954025	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccggcctcagccagagatGacaaagttcccagagccggc	10	6	11	14	2	1	3	1	1	0	2	3	4	3	3	5	2	2	1	5	2	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr18:32954025G>A	uc010xcf.1	-	2	364	c.232C>T	c.(232-234)CAT>TAT	p.H78Y		NM_145756	NP_665699	Q96N95	ZN396_HUMAN	zinc finger protein 396	78	SCAN box.				viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCCAGAGATGACAAAGTTCC	0.597													13	74					0	0	0	0	A	32954025	A	A	32954025	3	1	116	1	0	0	0	0	1	0	0	0	17949	1290	45	2	785	2	ZNF396	18	32954025	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1633986	32954025	45123223	327	21024											
SETBP1	26040	broad.mit.edu	37	chr18	42531993	42531993	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaggtactcttttgatttCtgctccctggacaacccgga	8	12	10	11	1	2	1	0	1	2	0	3	4	3	4	2	4	3	2	2	4	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr18:42531993C>T	uc010dni.2	+	4	2984	c.2688C>T	c.(2686-2688)TTC>TTT	p.F896F		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	896						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CTTTTGATTTCTGCTCCCTGG	0.557									Schinzel-Giedion_syndrome				12	24					0	0	0	0	T	42531993	T	T	42531993	2	4	116	1	0	0	0	0	0	0	0	1	14194	912	32	2		2	SETBP1	18	42531993	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	9577968	42531993	35545255	328	21025											
NETO1	81832	broad.mit.edu	37	chr18	70526106	70526106	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatcccatagattccagctCtccatcagcaaaaaatttaa	17	10	3	11	0	2	1	1	0	1	1	5	1	4	1	3	0	2	2	3	0	6	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr18:70526106C>G	uc002lkw.2	-	4	708	c.424G>C	c.(424-426)GAG>CAG	p.E142Q	NETO1_uc002lkx.1_Missense_Mutation_p.E141Q|NETO1_uc002lky.1_Missense_Mutation_p.E142Q|NETO1_uc002lkz.2_Missense_Mutation_p.E141Q	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	142	CUB 1.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GATTCCAGCTCTCCATCAGCA	0.338													14	37					0	0	0	0	G	70526106	G	G	70526106	3	3	116	1	0	0	0	0	1	0	0	0	10393	922	32	2	1214	2	NETO1	18	70526106	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	27994113	70526106	7551142	329	21026											
BSG	682	broad.mit.edu	37	chr19	579570	579570	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctgctccttgaatgacagCgccacagaggtcacagggca	11	6	11	13	1	1	3	1	2	0	1	2	3	2	3	3	2	2	2	3	2	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:579570C>T	uc002loz.2	+	3	584	c.486C>T	c.(484-486)AGC>AGT	p.S162S	BSG_uc002loy.2_Intron|BSG_uc002lpa.2_Silent_p.S46S|BSG_uc002lpb.2_RNA|BSG_uc010drr.2_Silent_p.S46S|BSG_uc002lpc.2_Silent_p.S209S|BSG_uc002lpd.2_5'Flank	NM_001728	NP_001719	P35613	BASI_HUMAN	basigin isoform 1 precursor	162	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|cell surface receptor linked signaling pathway|leukocyte migration|pyruvate metabolic process	Golgi membrane|integral to membrane|melanosome	lactate transmembrane transporter activity|mannose binding|protein binding				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAATGACAGCGCCACAGAGG	0.627													16	45					0	0	0	0	T	579570	T	T	579570	2	4	116	1	0	0	0	0	0	0	0	1	1534	767	27	1		1	BSG	19	579570	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08		579570	58549413	330	21027											
HCN2	610	broad.mit.edu	37	chr19	603773	603773	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agatcaagaagaagtatctgCgcacgtggttcgtggtggac	11	9	14	7	3	2	3	1	0	1	3	3	4	2	4	0	3	1	3	0	3	4	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:603773C>T	uc002lpe.2	+	2	915	c.862C>T	c.(862-864)CGC>TGC	p.R288C		NM_001194	NP_001185	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic	288	Cytoplasmic (Potential).				cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGTATCTGCGCACGTGGTT	0.547													7	66					0	0	0	0	T	603773	T	T	603773	3	4	116	1	0	0	0	0	1	0	0	0	7036	768	27	1	868	1	HCN2	19	603773	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	24203	603773	58525210	331	21028											
ATP8B3	148229	broad.mit.edu	37	chr19	1800407	1800407	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgactgagaaaccgaagccGaaggccaacaccaggcagac	15	3	11	12	2	0	3	0	2	0	2	0	6	0	3	4	2	3	1	4	2	4	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:1800407G>A	uc002ltw.2	-	13	1428	c.1194C>T	c.(1192-1194)TTC>TTT	p.F398F	ATP8B3_uc002ltv.2_Silent_p.F351F|ATP8B3_uc002ltx.2_RNA|ATP8B3_uc002lty.1_Silent_p.F146F|ATP8B3_uc002ltz.1_Silent_p.F345F	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	398	Helical; (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AACCGAAGCCGAAGGCCAACA	0.597													22	78					0	0	0	0	A	1800407	A	A	1800407	2	1	116	1	0	0	0	0	0	0	0	1	1198	1049	37	1		1	ATP8B3	19	1800407	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1196634	1800407	57328576	332	21029											
SEMA6B	10501	broad.mit.edu	37	chr19	4554425	4554425	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaggtagttaaactccatcGcaatctcccggaagaagaag	14	7	9	11	2	1	2	0	0	1	2	4	3	2	3	3	2	1	3	3	2	7	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:4554425G>A	uc010duc.1	-	8	784	c.746C>T	c.(745-747)GCG>GTG	p.A249V	SEMA6B_uc010dud.2_Missense_Mutation_p.A249V|SEMA6B_uc010xih.1_Missense_Mutation_p.A249V	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	249	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		AAACTCCATCGCAATCTCCCG	0.567													7	48					0	0	0	0	A	4554425	A	A	4554425	3	1	116	1	0	0	0	0	1	0	0	0	14105	1087	38	1	1956	1	SEMA6B	19	4554425	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2754018	4554425	54574558	333	21030											
GTF2F1	2962	broad.mit.edu	37	chr19	6389547	6389547	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtacttcttcctccgagcCtcctcccgaagcttgcggtt	4	12	8	17	4	1	0	0	0	1	0	5	2	5	0	6	1	4	3	6	1	2	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:6389547C>A	uc002meq.2	-	4	519	c.234G>T	c.(232-234)GAG>GAT	p.E78D	GTF2F1_uc010xjb.1_5'Flank|GTF2F1_uc010xjc.1_Missense_Mutation_p.E50D	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	78					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						TCCTCCGAGCCTCCTCCCGAA	0.607													35	166					2.42023e-17	3.46425e-17	1	0	A	6389547	A	A	6389547	3	1	116	1	0	0	0	0	1	0	0	0	6897	680	24	4	1359	4	GTF2F1	19	6389547	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1835122	6389547	52739436	334	21031											
EVI5L	115704	broad.mit.edu	37	chr19	7912766	7912766	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtggggccggatcgccaacGagtgggaggagtggcggcgc	6	5	21	9	5	0	0	0	0	0	0	1	4	0	3	2	7	1	0	2	7	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:7912766G>A	uc002min.2	+	3	440	c.286G>A	c.(286-288)GAG>AAG	p.E96K	EVI5L_uc010xjz.1_Missense_Mutation_p.E96K	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	96						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						GATCGCCAACGAGTGGGAGGA	0.697													4	7					0	0	0	0	A	7912766	A	A	7912766	3	1	116	1	0	0	0	0	1	0	0	0	5314	1059	37	1	292	1	EVI5L	19	7912766	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1523219	7912766	51216217	335	21032											
MUC16	94025	broad.mit.edu	37	chr19	9067629	9067629	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggctgggacagacgaataaGattccttttcagaagtggtg	12	10	13	6	1	1	3	1	0	0	3	2	5	2	4	1	3	0	1	1	3	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:9067629G>C	uc002mkp.2	-	3	20021	c.19817C>G	c.(19816-19818)TCT>TGT	p.S6606C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6608	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGACGAATAAGATTCCTTTTC	0.433													6	192					0	0	0	0	C	9067629	C	C	9067629	3	2	116	1	0	0	0	0	1	0	0	0	10026	942	33	2	24034	2	MUC16	19	9067629	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1154863	9067629	50061354	336	21033											
OR7G3	390883	broad.mit.edu	37	chr19	9237045	9237045	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatacaccaggatgttattGatgaggacatcagaacaggc	16	8	10	7	0	1	3	1	2	0	1	1	5	1	5	1	3	2	1	1	3	4	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:9237045G>A	uc010xkl.1	-	1	582	c.582C>T	c.(580-582)ATC>ATT	p.I194I		NM_001001958	NP_001001958	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGATGTTATTGATGAGGACAT	0.443													23	67					0	0	0	0	A	9237045	A	A	9237045	2	1	116	1	0	0	0	0	0	0	0	1	11278	1280	45	2		2	OR7G3	19	9237045	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	169416	9237045	49891938	337	21034											
AP1M1	8907	broad.mit.edu	37	chr19	16314374	16314374	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaggggatgctgtcgcccatCctggcccacgggggggtccg	4	6	18	13	3	0	0	0	0	0	0	3	2	2	1	4	6	1	1	4	6	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:16314374C>T	uc002ndu.2	+	2	320	c.147C>T	c.(145-147)ATC>ATT	p.I49I	AP1M1_uc002ndv.2_Silent_p.I49I|AP1M1_uc010xpd.1_Silent_p.I49I	NM_032493	NP_115882	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	49					cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(3)|breast(1)	4						TGTCGCCCATCCTGGCCCACG	0.592													20	44					0	0	0	0	T	16314374	T	T	16314374	2	4	116	1	0	0	0	0	0	0	0	1	734	845	30	2		2	AP1M1	19	16314374	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	7077329	16314374	42814609	338	21035											
ZNF253	56242	broad.mit.edu	37	chr19	20002713	20002713	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaaaccttactacacataaGagaattcataccggagagaa	18	7	7	9	1	1	2	1	0	0	2	1	5	1	3	2	1	4	1	2	1	7	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:20002713G>A	uc002noj.2	+	4	749	c.657G>A	c.(655-657)AAG>AAA	p.K219K	ZNF253_uc002nok.2_Silent_p.K143K|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	219	C2H2-type 2.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTACACATAAGAGAATTCATA	0.383													12	47					0	0	0	0	A	20002713	A	A	20002713	2	1	116	1	0	0	0	0	0	0	0	1	17864	933	33	2		2	ZNF253	19	20002713	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3688339	20002713	39126270	339	21036											
ZNF536	9745	broad.mit.edu	37	chr19	30934667	30934667	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccccgcatccctggaggaGaaggcccacgtgcccatgag	8	4	12	17	2	0	2	0	1	0	1	1	4	1	3	6	3	1	1	6	3	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:30934667G>A	uc002nsu.1	+	2	336	c.198G>A	c.(196-198)GAG>GAA	p.E66E	ZNF536_uc010edd.1_Silent_p.E66E	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	66					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCCTGGAGGAGAAGGCCCACG	0.687													14	48					0	0	0	0	A	30934667	A	A	30934667	2	1	116	1	0	0	0	0	0	0	0	1	18041	933	33	2		2	ZNF536	19	30934667	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	10931954	30934667	28194316	340	21037											
ZNF540	163255	broad.mit.edu	37	chr19	38102931	38102931	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatgtcaagaatgtgggaaGacctttactctttacccaca	13	11	8	9	0	2	2	1	0	1	2	2	4	2	3	2	1	2	0	2	1	6	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:38102931G>C	uc002ogq.2	+	5	1082	c.750G>C	c.(748-750)AAG>AAC	p.K250N	ZNF540_uc002ogu.2_Missense_Mutation_p.K250N|ZNF540_uc010efq.2_Missense_Mutation_p.K218N	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	250	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AATGTGGGAAGACCTTTACTC	0.353													7	34					0	0	0	0	C	38102931	C	C	38102931	3	2	116	1	0	0	0	0	1	0	0	0	18042	933	33	2	764	2	ZNF540	19	38102931	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7168264	38102931	21026052	341	21038											
SPRED3	399473	broad.mit.edu	37	chr19	38885397	38885397	+	Frame_Shift_Del	DEL	C	-	-																															caggcttcgggccgaccacgCccccccagcgccgccgctcc																								rs142553701	by1000genomes	TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:38885397delC	uc002oim.2	+	4	542	c.538delC	c.(538-540)CCCfs	p.P180fs		NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	180					multicellular organismal development					central_nervous_system(2)|lung(1)|skin(1)	4	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GCCGACCACGCCCCCCCAGCG	0.731													---	---	---								-	38885397	-	-	38885397	7	5	116	1	0	1	0	1	0	0	0	0	15160	739	26	0	592	0	SPRED3	19	38885397	Frame_Shift_Del	DEL	C	TCGA-CR-5248-01A-01D-2012-08	782466	38885397	20243586	342	21039											
FCGBP	8857	broad.mit.edu	37	chr19	40376432	40376432	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacccatctgggcactgcaGaggggcactgagagccgagc	10	4	14	13	1	1	2	0	1	1	2	1	4	1	2	2	3	3	3	2	3	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:40376432G>C	uc002omp.3	-	25	11880	c.11872C>G	c.(11872-11874)CTG>GTG	p.L3958V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	3958	TIL 9.|Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGGCACTGCAGAGGGGCACTG	0.632													5	29					0	0	0	0	C	40376432	C	C	40376432	3	2	116	1	0	0	0	0	1	0	0	0	5810	933	33	2	4393	2	FCGBP	19	40376432	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1491035	40376432	18752551	343	21040											
HIPK4	147746	broad.mit.edu	37	chr19	40889957	40889957	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagggcagccccagcaggatCtcaggggcccggtagaagcg	10	3	16	12	2	1	1	1	0	1	1	2	2	1	2	3	5	3	3	3	5	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:40889957C>G	uc002onp.2	-	2	840	c.555G>C	c.(553-555)GAG>GAC	p.E185D		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	185	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			CCAGCAGGATCTCAGGGGCCC	0.632													16	57					0	0	0	0	G	40889957	G	G	40889957	3	3	116	1	0	0	0	0	1	0	0	0	7158	912	32	2	1307	2	HIPK4	19	40889957	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	513525	40889957	18239026	344	21041											
PRX	57716	broad.mit.edu	37	chr19	40900746	40900746	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgctgaagggactgtactCtgagcctgctgccctggggt	5	11	14	11	0	2	2	0	2	2	0	2	3	2	3	2	3	5	3	2	3	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:40900746C>G	uc002onr.2	-	7	3782	c.3513G>C	c.(3511-3513)CAG>CAC	p.Q1171H	PRX_uc002onq.2_Missense_Mutation_p.Q1032H|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1171	Glu-rich (acidic).				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGACTGTACTCTGAGCCTGCT	0.662													4	132					0	0	0	0	G	40900746	G	G	40900746	3	3	116	1	0	0	0	0	1	0	0	0	12704	912	32	2	876	2	PRX	19	40900746	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	10789	40900746	18228237	345	21042											
ATP1A3	478	broad.mit.edu	37	chr19	42482830	42482830	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccttcatttcctcgtccaGaggctgctccttgccctgta	4	14	7	16	1	1	1	1	0	0	1	6	1	5	1	5	1	2	3	5	1	1	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:42482830G>A	uc002osg.2	-	12	1712	c.1558C>T	c.(1558-1560)CTG>TTG	p.L520L	ATP1A3_uc010xwf.1_Silent_p.L531L|ATP1A3_uc010xwg.1_Silent_p.L490L|ATP1A3_uc010xwh.1_Silent_p.L533L|ATP1A3_uc002osh.2_Silent_p.L520L	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	520	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						TCCTCGTCCAGAGGCTGCTCC	0.657													19	89					0	0	0	0	A	42482830	A	A	42482830	2	1	116	1	0	0	0	0	0	0	0	1	1132	933	33	2		2	ATP1A3	19	42482830	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1582084	42482830	16646153	346	21043											
ZNF284	342909	broad.mit.edu	37	chr19	44590114	44590114	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcttcagtgatgtctccatCcttgatcttcatcaacaatt	9	17	4	11	0	6	2	3	2	3	0	8	2	7	2	2	0	1	0	2	0	2	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:44590114C>A	uc002oyg.1	+	5	699	c.483C>A	c.(481-483)ATC>ATA	p.I161I	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	161	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				ATGTCTCCATCCTTGATCTTC	0.408													8	23					0.000157383	0.000212268	1	0	A	44590114	A	A	44590114	2	1	116	1	0	0	0	0	0	0	0	1	17888	845	30	2		2	ZNF284	19	44590114	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2107284	44590114	14538869	347	21044											
PVRL2	5819	broad.mit.edu	37	chr19	45391518	45391518	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctagaggatgaggagggggAggaggaggaagagtatctgg	12	6	21	2	0	2	3	0	1	2	2	2	9	2	9	0	8	0	1	0	8	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:45391518A>G	uc002ozw.1	+	9	1889	c.1499A>G	c.(1498-1500)GAG>GGG	p.E500G	TOMM40_uc002ozx.3_5'Flank|TOMM40_uc002ozy.3_5'Flank|TOMM40_uc002paa.3_5'Flank|TOMM40_uc002ozz.2_5'Flank	NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	500	Cytoplasmic (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		gaggagggggaggaggaggaa	0.483													10	49					0	0	0	0	G	45391518	G	G	45391518	3	3	116	1	0	0	0	0	1	0	0	0	12905	304	11	5	1935	5	PVRL2	19	45391518	Missense_Mutation	SNP	A	TCGA-CR-5248-01A-01D-2012-08	801404	45391518	13737465	348	21045											
SLC1A5	6510	broad.mit.edu	37	chr19	47290911	47290911	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcacaccaccagcggcaaGatgatcatccgcagcagacg	12	4	10	15	3	1	3	1	1	0	2	2	3	2	3	3	1	3	4	3	1	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:47290911G>C	uc002pfs.2	-	1	932	c.312C>G	c.(310-312)ATC>ATG	p.I104M	SLC1A5_uc010xyh.1_5'Flank|SLC1A5_uc002pfq.2_5'Flank|SLC1A5_uc002pfr.2_5'Flank	NM_005628	NP_005619	Q15758	AAAT_HUMAN	solute carrier family 1 member 5 isoform 1	104	Helical; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity				0		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	CCAGCGGCAAGATGATCATCC	0.721													4	13					0	0	0	0	C	47290911	C	C	47290911	3	2	116	1	0	0	0	0	1	0	0	0	14500	932	33	2	1352	2	SLC1A5	19	47290911	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1899393	47290911	11838072	349	21046											
CYTH2	9266	broad.mit.edu	37	chr19	48981790	48981790	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggtggagggaaaccacatGgtgtaccggatctcggcccc	8	7	15	11	2	1	0	0	0	1	0	2	3	1	3	4	6	2	1	4	6	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:48981790G>T	uc002pjj.3	+	12	1356	c.1056G>T	c.(1054-1056)ATG>ATT	p.M352I	CYTH2_uc002pji.2_RNA	NM_017457	NP_059431	Q99418	CYH2_HUMAN	cytohesin 2 isoform 1	352	PH.				actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GAAACCACATGGTGTACCGGA	0.458													9	60					0.000274275	0.000369071	1	0	T	48981790	T	T	48981790	3	4	116	1	0	0	0	0	1	0	0	0	4221	1348	47	4	1098	4	CYTH2	19	48981790	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1690879	48981790	10147193	350	21047											
CPT1C	126129	broad.mit.edu	37	chr19	50208329	50208329	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggaatgccgtccatgccctCctcctgtaccgccaccgcct	5	8	9	19	3	0	0	0	0	0	0	3	1	3	1	9	1	3	1	9	1	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:50208329C>T	uc002ppj.2	+	8	1042	c.837C>T	c.(835-837)CTC>CTT	p.L279L	CPT1C_uc002ppl.3_Silent_p.L245L|CPT1C_uc002ppi.2_Silent_p.L196L|CPT1C_uc002ppk.2_Silent_p.L268L|CPT1C_uc010eng.2_Silent_p.L279L|CPT1C_uc010enh.2_Silent_p.L279L|CPT1C_uc010ybc.1_Silent_p.L117L|CPT1C_uc010eni.1_5'Flank	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	279	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TCCATGCCCTCCTCCTGTACC	0.652													21	66					0	0	0	0	T	50208329	T	T	50208329	2	4	116	1	0	0	0	0	0	0	0	1	3848	842	30	2		2	CPT1C	19	50208329	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1226539	50208329	8920654	351	21048											
ZNF473	25888	broad.mit.edu	37	chr19	50549839	50549839	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcgggaaaacgttccgtcaGagctcatgcctttctaagca	10	10	10	11	3	3	1	2	0	1	1	4	2	4	2	2	1	5	3	2	1	3	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:50549839G>C	uc002prn.2	+	5	2376	c.2139G>C	c.(2137-2139)CAG>CAC	p.Q713H	ZNF473_uc002prm.2_Missense_Mutation_p.Q713H|ZNF473_uc010ybo.1_Missense_Mutation_p.Q701H	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	713	C2H2-type 15.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		CGTTCCGTCAGAGCTCATGCC	0.502											OREG0025632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	82					0	0	0	0	C	50549839	C	C	50549839	3	2	116	1	0	0	0	0	1	0	0	0	17998	933	33	2	2153	2	ZNF473	19	50549839	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	341510	50549839	8579144	352	21049											
MYBPC2	4606	broad.mit.edu	37	chr19	50951529	50951529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcgcggatctgacggtgaagGcctcagaacaagctgtgttc	9	9	13	10	3	2	3	1	2	1	1	4	4	2	4	1	3	2	2	1	3	3	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:50951529G>A	uc002psf.2	+	13	1405	c.1354G>A	c.(1354-1356)GCC>ACC	p.A452T		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	452	Ig-like C2-type 4.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GACGGTGAAGGCCTCAGAACA	0.507													5	53					0	0	0	0	A	50951529	A	A	50951529	3	1	116	1	0	0	0	0	1	0	0	0	10065	1203	42	4	1404	4	MYBPC2	19	50951529	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	401690	50951529	8177454	353	21050											
ZNF175	7728	broad.mit.edu	37	chr19	52090088	52090088	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcaacaagaaaacattgaaCacagaaagcaattgtgaata	21	8	6	6	0	1	4	1	2	0	2	1	4	1	4	0	0	4	1	0	0	9	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:52090088C>A	uc002pxb.2	+	5	882	c.504C>A	c.(502-504)AAC>AAA	p.N168K		NM_007147	NP_009078	Q9Y473	ZN175_HUMAN	zinc finger protein 175	168					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		AAACATTGAACACAGAAAGCA	0.413													18	49					3.32936e-07	4.58572e-07	1	0	A	52090088	A	A	52090088	3	1	116	1	0	0	0	0	1	0	0	0	17812	477	17	4	518	4	ZNF175	19	52090088	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1138559	52090088	7038895	354	21051											
NLRP12	91662	broad.mit.edu	37	chr19	54308652	54308652	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaattcttattggctatgaGagctgcagagaggtcctcgc	10	11	11	9	1	1	2	0	1	1	2	3	4	2	2	1	2	2	3	1	2	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:54308652G>C	uc002qch.3	-	5	2516	c.2296C>G	c.(2296-2298)CTC>GTC	p.L766V	NLRP12_uc010eqw.2_Missense_Mutation_p.L49V|NLRP12_uc002qci.3_Missense_Mutation_p.L766V|NLRP12_uc002qcj.3_Missense_Mutation_p.L767V|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.L767V	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	766					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TTGGCTATGAGAGCTGCAGAG	0.557													13	105					0	0	0	0	C	54308652	C	C	54308652	3	2	116	1	0	0	0	0	1	0	0	0	10528	942	33	2	913	2	NLRP12	19	54308652	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2218564	54308652	4820331	355	21052											
CACNG6	59285	broad.mit.edu	37	chr19	54496185	54496185	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccggcggcggggggccgcGggccggcggcgggcgcacgg	3	0	24	14	10	0	0	0	0	0	0	0	0	0	0	3	10	1	1	3	10	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:54496185G>A	uc002qct.2	+	1	644	c.54G>A	c.(52-54)GCG>GCA	p.A18A	CACNG6_uc002qcu.2_Silent_p.A18A|CACNG6_uc002qcv.2_Silent_p.A18A	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	18						voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		ggggggccgcgggccggcggc	0.567													4	18					0	0	0	0	A	54496185	A	A	54496185	2	1	116	1	0	0	0	0	0	0	0	1	2573	1103	39	1		1	CACNG6	19	54496185	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	187533	54496185	4632798	356	21053											
EPS8L1	54869	broad.mit.edu	37	chr19	55593493	55593493	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgcgggccaagccgccctCggaggccgagtacaccgacg	7	3	15	16	6	0	0	0	0	0	0	1	3	0	1	5	3	3	2	5	3	2	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:55593493C>T	uc002qis.3	+	10	1039	c.935C>T	c.(934-936)TCG>TTG	p.S312L	EPS8L1_uc010ess.1_Missense_Mutation_p.S294L|EPS8L1_uc010est.1_Missense_Mutation_p.S312L|EPS8L1_uc010yfr.1_Missense_Mutation_p.S248L|EPS8L1_uc010esu.1_RNA|EPS8L1_uc002qiu.2_Missense_Mutation_p.S185L|EPS8L1_uc002qiv.2_5'UTR|EPS8L1_uc002qiw.2_Missense_Mutation_p.S59L	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	epidermal growth factor receptor pathway	312						cytoplasm					0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		AAGCCGCCCTCGGAGGCCGAG	0.582													7	6					0	0	0	0	T	55593493	T	T	55593493	3	4	116	1	0	0	0	0	1	0	0	0	5219	893	31	1	1021	1	EPS8L1	19	55593493	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1097308	55593493	3535490	357	21054											
ZNF543	125919	broad.mit.edu	37	chr19	57840200	57840200	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctatgaatgcaaagaatgtgGaaaagcctttagtgataggg	15	10	12	4	0	0	3	0	2	0	1	0	4	0	4	1	2	2	1	1	2	8	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:57840200G>C	uc002qoi.1	+	4	1715	c.1370G>C	c.(1369-1371)GGA>GCA	p.G457A		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	457	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAAGAATGTGGAAAAGCCTTT	0.488													15	52					0	0	0	0	C	57840200	C	C	57840200	3	2	116	1	0	0	0	0	1	0	0	0	18043	1174	41	2	1384	2	ZNF543	19	57840200	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	2246707	57840200	1288783	358	21055											
ZNF446	55663	broad.mit.edu	37	chr19	58991811	58991811	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caccggacacacacgagtggGccaggtgtgcagtccccggg	8	4	15	14	3	0	0	0	0	0	0	1	2	1	1	4	4	1	1	4	4	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr19:58991811G>A	uc002qsz.2	+	7	1188	c.1071G>A	c.(1069-1071)GGG>GGA	p.G357G	ZNF446_uc002qta.2_Missense_Mutation_p.G329D|ZNF446_uc010eur.2_3'UTR|SLC27A5_uc002qtb.2_RNA	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	357	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		ACACGAGTGGGCCAGGTGTGC	0.662													11	40					0	0	0	0	A	58991811	A	A	58991811	2	1	116	1	0	0	0	0	0	0	0	1	17986	1190	42	4		4	ZNF446	19	58991811	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1151611	58991811	137172	359	21056											
FLRT3	23767	broad.mit.edu	37	chr20	14307152	14307152	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaccttttctggggcttggCacatgagcccacgcacgttg	7	10	12	12	2	1	1	0	1	1	0	1	2	1	1	2	3	2	4	2	3	1	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr20:14307152C>T	uc002wov.1	-	3	1468	c.1001G>A	c.(1000-1002)TGC>TAC	p.C334Y	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.C334Y	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	334	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TGGGGCTTGGCACATGAGCCC	0.473													22	87					0	0	0	0	T	14307152	T	T	14307152	3	4	116	1	0	0	0	0	1	0	0	0	5972	710	25	4	952	4	FLRT3	20	14307152	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		14307152	48718368	360	21057											
DNMT3B	1789	broad.mit.edu	37	chr20	31385005	31385005	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgccaggatcgcttccttGagctgttttacatgtatgat	7	15	10	9	1	0	2	0	2	0	0	2	3	1	3	2	1	3	5	2	1	2	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr20:31385005G>C	uc002wyc.2	+	14	1711	c.1390G>C	c.(1390-1392)GAG>CAG	p.E464Q	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Missense_Mutation_p.E444Q|DNMT3B_uc002wye.2_Missense_Mutation_p.E444Q|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.E402Q|DNMT3B_uc010zua.1_Missense_Mutation_p.E368Q|DNMT3B_uc002wyf.2_Missense_Mutation_p.E456Q|DNMT3B_uc002wyg.2_Missense_Mutation_p.E163Q	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	464	GATA-type; atypical.|ADD.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						TCGCTTCCTTGAGCTGTTTTA	0.572													23	119					0	0	0	0	C	31385005	C	C	31385005	3	2	116	1	0	0	0	0	1	0	0	0	4699	1291	45	2	1480	2	DNMT3B	20	31385005	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	17077853	31385005	31640515	361	21058											
RBL1	5933	broad.mit.edu	37	chr20	35696531	35696531	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctatacgttcacgaaattCttgtggtagatttgacatgt	10	17	8	6	2	3	2	1	1	2	1	3	3	3	2	0	1	1	2	0	1	4	8			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr20:35696531C>G	uc002xgi.2	-	3	428	c.349G>C	c.(349-351)GAA>CAA	p.E117Q	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.E117Q|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	117					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				TCACGAAATTCTTGTGGTAGA	0.279													7	16					0	0	0	0	G	35696531	G	G	35696531	3	3	116	1	0	0	0	0	1	0	0	0	13174	922	32	2	2946	2	RBL1	20	35696531	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	4311526	35696531	27328989	362	21059											
CHD6	84181	broad.mit.edu	37	chr20	40045305	40045305	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggctctgagaggctggttcGagaaccagcactgctggtta	8	9	14	10	2	1	2	0	1	1	2	2	4	1	2	1	4	3	6	1	4	2	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr20:40045305G>A	uc002xka.1	-	33	6587	c.6409C>T	c.(6409-6411)CGA>TGA	p.R2137*	CHD6_uc002xjz.1_5'Flank	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2137					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				AGGCTGGTTCGAGAACCAGCA	0.587													5	88					0	0	0	0	A	40045305	A	A	40045305	4	1	116	1	0	0	0	0	0	1	0	0	3344	1066	37	1	1758	1	CHD6	20	40045305	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	4348774	40045305	22980215	363	21060											
SLC2A10	81031	broad.mit.edu	37	chr20	45354422	45354422	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caactaacagggcagcccaaCgtgctgtgctatgcctccac	10	7	9	15	1	0	0	0	0	0	0	1	0	1	0	3	1	7	3	3	1	4	2	rs41283042		TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr20:45354422C>T	uc002xsl.2	+	2	844	c.747C>T	c.(745-747)AAC>AAT	p.N249N		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	249	Helical; Name=7; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GGCAGCCCAACGTGCTGTGCT	0.617													38	112					0	0	0	0	T	45354422	T	T	45354422	2	4	116	1	0	0	0	0	0	0	0	1	14603	535	19	1		1	SLC2A10	20	45354422	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	5309117	45354422	17671098	364	21061											
LAMA5	3911	broad.mit.edu	37	chr20	60897442	60897442	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggggtggcactcggagccctCggcggccggtccacaagcac	6	4	16	15	4	0	0	0	0	0	0	3	1	1	1	3	7	2	2	3	7	1	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr20:60897442C>T	uc002ycq.2	-	47	6296	c.6229G>A	c.(6229-6231)GAG>AAG	p.E2077K		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2077	Laminin EGF-like 21.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCGGAGCCCTCGGCGGCCGGT	0.706													4	14					0	0	0	0	T	60897442	T	T	60897442	3	4	116	1	0	0	0	0	1	0	0	0	8649	893	31	1	4994	1	LAMA5	20	60897442	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	15543020	60897442	2128078	365	21062											
PPDPF	79144	broad.mit.edu	37	chr20	62153084	62153084	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcgggaagtccaccctccCgttcatggccacggtgttgg	5	11	12	13	3	1	0	1	0	0	0	4	1	3	1	4	4	0	2	4	4	1	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr20:62153084C>T	uc002yff.2	+	4	337	c.197C>T	c.(196-198)CCG>CTG	p.P66L		NM_024299	NP_077275	Q9H3Y8	PPDPF_HUMAN	pancreatic progenitor cell differentiation and	66					cell differentiation|multicellular organismal development						0						TCCACCCTCCCGTTCATGGCC	0.642													15	42					0	0	0	0	T	62153084	T	T	62153084	3	4	116	1	0	0	0	0	1	0	0	0	12361	652	23	1	207	1	PPDPF	20	62153084	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	1255642	62153084	872436	366	21063											
ZNF512B	57473	broad.mit.edu	37	chr20	62597952	62597952	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgacaggtttgctcactccGatgggcttgctgaccccaac	7	10	11	13	1	1	2	1	2	0	0	2	3	2	2	3	2	3	4	3	2	1	2	rs143583869	byFrequency	TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr20:62597952G>A	uc002yhl.1	-	5	630	c.576C>T	c.(574-576)ATC>ATT	p.I192I		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TGCTCACTCCGATGGGCTTGC	0.612													43	105					0	0	0	0	A	62597952	A	A	62597952	2	1	116	1	0	0	0	0	0	0	0	1	18024	1048	37	1		1	ZNF512B	20	62597952	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	444868	62597952	427568	367	21064											
KRTAP19-1	337882	broad.mit.edu	37	chr21	31852536	31852536	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccacagccagaaccccgtCtgcagaagctgccacatcca	12	4	8	17	1	1	2	0	0	1	2	2	2	2	2	6	0	6	2	6	0	2	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr21:31852536C>T	uc011acx.1	-	1	101	c.101G>A	c.(100-102)AGA>AAA	p.R34K		NM_181607	NP_853638	Q8IUB9	KR191_HUMAN	keratin associated protein 19-1	34	26 X 2 AA repeats of G-[YCGS].					intermediate filament					0						AGAACCCCGTCTGCAGAAGCT	0.587													71	211					0	0	0	0	T	31852536	T	T	31852536	3	4	116	1	0	0	0	0	1	0	0	0	8567	913	32	2	173	2	KRTAP19-1	21	31852536	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08		31852536	16277359	368	21065											
TTC3	7267	broad.mit.edu	37	chr21	38520891	38520891	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtactgtaaaatagaatttCacatgaattgctggaagaag	17	11	9	4	0	1	3	1	1	0	2	1	4	1	4	0	1	2	3	0	1	8	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr21:38520891C>G	uc002yvz.2	+	23	2167	c.2062C>G	c.(2062-2064)CAC>GAC	p.H688D	TTC3_uc011aee.1_Missense_Mutation_p.H378D|TTC3_uc002ywa.2_Missense_Mutation_p.H688D|TTC3_uc002ywb.2_Missense_Mutation_p.H688D|TTC3_uc010gnf.2_Missense_Mutation_p.H453D|TTC3_uc002ywc.2_Missense_Mutation_p.H378D|TTC3_uc011aed.1_Missense_Mutation_p.H378D	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	688					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				AATAGAATTTCACATGAATTG	0.308													24	86					0	0	0	0	G	38520891	G	G	38520891	3	3	116	1	0	0	0	0	1	0	0	0	16765	826	29	2	2148	2	TTC3	21	38520891	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	6668355	38520891	9609004	369	21066											
DYRK1A	1859	broad.mit.edu	37	chr21	38862551	38862551	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgtcctacaacctctatGacttgctgagaaacaccaat	12	11	6	12	0	1	2	0	2	1	1	2	3	2	2	3	0	5	2	3	0	5	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr21:38862551G>A	uc002ywk.2	+	6	814	c.739G>A	c.(739-741)GAC>AAC	p.D247N	DYRK1A_uc002ywi.2_Missense_Mutation_p.D247N|DYRK1A_uc002ywj.2_Missense_Mutation_p.D238N|DYRK1A_uc002ywl.2_Missense_Mutation_p.D247N|DYRK1A_uc002ywm.2_Missense_Mutation_p.D247N|DYRK1A_uc011aei.1_Missense_Mutation_p.D8N	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	247	Protein kinase.				nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4						CAACCTCTATGACTTGCTGAG	0.413													18	66					0	0	0	0	A	38862551	A	A	38862551	3	1	116	1	0	0	0	0	1	0	0	0	4876	1290	45	2	761	2	DYRK1A	21	38862551	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	341660	38862551	9267344	370	21067											
ETS2	2114	broad.mit.edu	37	chr21	40193623	40193623	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtttaagctcgccgaccccGatgaggtatggccagagccc	9	7	12	13	3	0	2	0	1	0	1	1	4	0	2	5	2	2	3	5	2	2	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr21:40193623G>A	uc002yxg.2	+	9	1385	c.1189G>A	c.(1189-1191)GAT>AAT	p.D397N	ETS2_uc002yxf.2_Missense_Mutation_p.D537N	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	397	ETS.				positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				CGCCGACCCCGATGAGGTATG	0.507													34	88					0	0	0	0	A	40193623	A	A	40193623	3	1	116	1	0	0	0	0	1	0	0	0	5300	1058	37	1	1219	1	ETS2	21	40193623	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1331072	40193623	7936272	371	21068											
RIPK4	54101	broad.mit.edu	37	chr21	43165984	43165984	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtttctttcacttcgtcatCaggcttttcacacaggtcct	7	16	6	12	1	5	0	4	0	1	0	7	0	6	0	1	2	0	2	1	2	0	5			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr21:43165984C>T	uc002yzn.1	-	6	919	c.871G>A	c.(871-873)GAT>AAT	p.D291N		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	291						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						ACTTCGTCATCAGGCTTTTCA	0.522													31	68					0	0	0	0	T	43165984	T	T	43165984	3	4	116	1	0	0	0	0	1	0	0	0	13448	826	29	2	1495	2	RIPK4	21	43165984	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	2972361	43165984	4963911	372	21069											
ITGB2	3689	broad.mit.edu	37	chr21	46320373	46320373	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagcagccgcgtgacgttGcgccagccgatttcctcctg	6	8	11	16	5	0	1	0	1	0	0	2	2	2	1	6	0	4	2	6	0	0	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr21:46320373G>A	uc002zgd.2	-	6	803	c.759C>T	c.(757-759)CGC>CGT	p.R253R	ITGB2_uc002zge.2_Silent_p.R253R|ITGB2_uc002zgf.3_Silent_p.R253R|ITGB2_uc011afl.1_Silent_p.R175R|ITGB2_uc010gpw.2_Silent_p.R196R|ITGB2_uc002zgg.2_Silent_p.R253R	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	253	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GCGTGACGTTGCGCCAGCCGA	0.652													11	46					0	0	0	0	A	46320373	A	A	46320373	2	1	116	1	0	0	0	0	0	0	0	1	7933	1306	46	4		4	ITGB2	21	46320373	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	3154389	46320373	1809522	373	21070											
COL6A2	1292	broad.mit.edu	37	chr21	47536580	47536580	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacagggtgaatttggagccGacggtcgcaaggtaggctgg	9	7	17	8	3	0	1	0	1	0	0	1	3	0	2	1	6	1	3	1	6	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr21:47536580G>A	uc002zia.1	+	9	1025	c.943G>A	c.(943-945)GAC>AAC	p.D315N	COL6A2_uc002zhy.1_Missense_Mutation_p.D315N|COL6A2_uc002zhz.1_Missense_Mutation_p.D315N|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	315	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ATTTGGAGCCGACGGTCGCAA	0.617													13	32					0	0	0	0	A	47536580	A	A	47536580	3	1	116	1	0	0	0	0	1	0	0	0	3715	1058	37	1	973	1	COL6A2	21	47536580	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1216207	47536580	593315	374	21071											
SERPIND1	3053	broad.mit.edu	37	chr22	21134215	21134215	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cataatctcttccgtaagctGactcatcgcctcttcaggag	9	12	7	13	2	4	1	2	1	2	0	7	2	5	2	2	1	1	2	2	1	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr22:21134215G>A	uc002ztb.1	+	2	682	c.615G>A	c.(613-615)CTG>CTA	p.L205L	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Silent_p.L233L	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	205	Glycosaminoglycan-binding site.				blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	TCCGTAAGCTGACTCATCGCC	0.418													17	72					0	0	0	0	A	21134215	A	A	21134215	2	1	116	1	0	0	0	0	0	0	0	1	14175	1277	45	2		2	SERPIND1	22	21134215	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08		21134215	30170351	375	21072											
HIC2	23119	broad.mit.edu	37	chr22	21800507	21800507	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtcctacggggacaacttGtatgtgtgcattccctgcgc	6	12	12	11	2	0	0	0	0	0	0	2	1	2	1	2	2	4	2	2	2	3	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr22:21800507G>C	uc002zur.3	+	3	1553	c.1323G>C	c.(1321-1323)TTG>TTC	p.L441F	HIC2_uc002zus.3_Missense_Mutation_p.L441F	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	441					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GGGACAACTTGTATGTGTGCA	0.622													18	102					0	0	0	0	C	21800507	C	C	21800507	3	2	116	1	0	0	0	0	1	0	0	0	7141	1368	48	4	1329	4	HIC2	22	21800507	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	666292	21800507	29504059	376	21073											
GAS2L1	10634	broad.mit.edu	37	chr22	29706633	29706633	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcccacacctgcaggtgctGaggagccacgtgatggtgcg	7	7	15	12	2	0	2	0	2	0	0	0	3	0	3	3	3	5	2	3	3	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr22:29706633G>C	uc003afa.1	+	4	946	c.747G>C	c.(745-747)CTG>CTC	p.L249L	GAS2L1_uc010gvm.1_Silent_p.L249L|GAS2L1_uc003afb.1_Silent_p.L249L|GAS2L1_uc003afc.1_Silent_p.L249L|GAS2L1_uc003afd.1_Silent_p.L249L|GAS2L1_uc003afe.1_Silent_p.L249L	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	249	GAR.				cell cycle arrest	cytoplasm|cytoskeleton					0						TGCAGGTGCTGAGGAGCCACG	0.711													4	16					0	0	0	0	C	29706633	C	C	29706633	2	2	116	1	0	0	0	0	0	0	0	1	6281	1277	45	2		2	GAS2L1	22	29706633	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	7906126	29706633	21597933	377	21074											
MORC2	22880	broad.mit.edu	37	chr22	31333850	31333850	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggtgctcccccattgctcGgagcaggtgccggtactcct	5	9	12	15	2	0	0	0	0	0	0	3	1	2	1	4	4	5	4	4	4	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr22:31333850G>A	uc003aje.1	-	15	2499	c.1135C>T	c.(1135-1137)CGA>TGA	p.R379*		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	441							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						CCCATTGCTCGGAGCAGGTGC	0.567													12	63					0	0	0	0	A	31333850	A	A	31333850	4	1	116	1	0	0	0	0	0	1	0	0	9755	1124	39	1	1829	1	MORC2	22	31333850	Nonsense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	1627217	31333850	19970716	378	21075											
LIMK2	3985	broad.mit.edu	37	chr22	31654293	31654293	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcaggtgttcagaatgccagGattccctcaccaactggtac	10	10	9	12	0	3	1	3	0	0	1	4	2	4	2	3	3	3	2	3	3	3	3	rs35923988		TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr22:31654293G>A	uc003akh.2	+	3	278	c.133G>A	c.(133-135)GAT>AAT	p.D45N	LIMK2_uc003akg.2_5'UTR|LIMK2_uc003aki.2_Intron|LIMK2_uc003akj.2_Missense_Mutation_p.D24N|LIMK2_uc003akk.2_Missense_Mutation_p.D24N|LIMK2_uc011aln.1_5'UTR	NM_005569	NP_005560	P53671	LIMK2_HUMAN	LIM domain kinase 2 isoform 2a	45	LIM zinc-binding 1.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2						AGAATGCCAGGATTCCCTCAC	0.517													15	64					0	0	0	0	A	31654293	A	A	31654293	3	1	116	1	0	0	0	0	1	0	0	0	8843	1174	41	2	200	2	LIMK2	22	31654293	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	320443	31654293	19650273	379	21076											
LIMK2	3985	broad.mit.edu	37	chr22	31654368	31654368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actactgggggaagtttgggGagttctgtcatgggtgctcc	6	12	16	7	0	2	0	1	0	1	0	3	2	3	2	1	5	2	3	1	5	2	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr22:31654368G>A	uc003akh.2	+	3	353	c.208G>A	c.(208-210)GAG>AAG	p.E70K	LIMK2_uc003akg.2_5'UTR|LIMK2_uc003aki.2_Intron|LIMK2_uc003akj.2_Missense_Mutation_p.E49K|LIMK2_uc003akk.2_Missense_Mutation_p.E49K|LIMK2_uc011aln.1_5'UTR	NM_005569	NP_005560	P53671	LIMK2_HUMAN	LIM domain kinase 2 isoform 2a	70						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2						GAAGTTTGGGGAGTTCTGTCA	0.522													17	53					0	0	0	0	A	31654368	A	A	31654368	3	1	116	1	0	0	0	0	1	0	0	0	8843	1175	41	2	275	2	LIMK2	22	31654368	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	75	31654368	19650198	380	21077											
CACNG2	10369	broad.mit.edu	37	chr22	36960607	36960607	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgaagcccttgatgcccaCgggggaggcgtccctggagt	6	8	16	11	2	0	2	0	2	0	0	1	4	1	4	3	4	2	1	3	4	1	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr22:36960607C>T	uc003aps.1	-	4	1045	c.763G>A	c.(763-765)GTG>ATG	p.V255M		NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	255					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						TTGATGCCCACGGGGGAGGCG	0.687													32	91					0	0	0	0	T	36960607	T	T	36960607	3	4	116	1	0	0	0	0	1	0	0	0	2569	536	19	1	212	1	CACNG2	22	36960607	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	5306239	36960607	14343959	381	21078											
MLC1	23209	broad.mit.edu	37	chr22	50500060	50500060	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccaggctttctccttgtcGaactccttcagggggctcct	4	13	9	15	1	2	0	1	0	1	0	7	1	5	0	4	3	1	2	4	3	1	3			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr22:50500060G>A	uc003bjg.1	-	12	1359	c.1086C>T	c.(1084-1086)TTC>TTT	p.F362F	MLC1_uc011arl.1_Silent_p.F310F|MLC1_uc003bjh.1_Silent_p.F362F|MLC1_uc011arm.1_Silent_p.F332F|MLC1_uc011arn.1_Silent_p.F283F|MLC1_uc011aro.1_Silent_p.F328F	NM_139202	NP_631941	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with	362						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		TCTCCTTGTCGAACTCCTTCA	0.652													12	56					0	0	0	0	A	50500060	A	A	50500060	2	1	116	1	0	0	0	0	0	0	0	1	9665	1049	37	1		1	MLC1	22	50500060	Silent	SNP	G	TCGA-CR-5248-01A-01D-2012-08	13539453	50500060	804506	382	21079											
MIOX	55586	broad.mit.edu	37	chr22	50927676	50927676	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcacagagctcgggatgtatCagccccactgtgggctcgac	8	7	13	13	2	1	1	1	0	0	1	3	3	1	2	2	2	2	4	2	2	1	1			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chr22:50927676C>T	uc003bll.1	+	7	652	c.538C>T	c.(538-540)CAG>TAG	p.Q180*	MIOX_uc003blm.1_Nonsense_Mutation_p.Q180*|MIOX_uc003bln.1_Silent_p.I190I	NM_017584	NP_060054	Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	180					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGGGATGTATCAGCCCCACTG	0.562													4	17					0	0	0	0	T	50927676	T	T	50927676	4	4	116	1	0	0	0	0	0	1	0	0	9643	827	29	2	564	2	MIOX	22	50927676	Nonsense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	427616	50927676	376890	383	21080											
CXorf22	170063	broad.mit.edu	37	chrX	35974178	35974178	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttaattttaaaccttgtttCatgggtgaacgttcagaaat	12	16	7	6	1	2	2	2	1	0	1	2	2	2	2	1	1	2	2	1	1	5	6			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chrX:35974178C>T	uc004ddj.2	+	8	1334	c.1275C>T	c.(1273-1275)TTC>TTT	p.F425F	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	425										large_intestine(1)|lung(1)|ovary(1)	3						AACCTTGTTTCATGGGTGAAC	0.363													17	15					0	0	0	0	T	35974178	T	T	35974178	2	4	116	1	0	0	0	0	0	0	0	1	4119	825	29	2		2	CXorf22	23	35974178	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08		35974178	119296382	384	21081											
HUWE1	10075	broad.mit.edu	37	chrX	53618007	53618007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggtgggttaaaaggtactCtgtggcctgctccatggtgc	7	11	15	8	0	1	0	0	0	1	0	2	0	2	0	2	5	3	3	2	5	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chrX:53618007C>T	uc004dsp.2	-	34	4450	c.4048G>A	c.(4048-4050)GAG>AAG	p.E1350K	HUWE1_uc004dsn.2_Missense_Mutation_p.E175K	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1350	UBA.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AAAAGGTACTCTGTGGCCTGC	0.498													14	11					0	0	0	0	T	53618007	T	T	53618007	3	4	116	1	0	0	0	0	1	0	0	0	7500	922	32	2	9280	2	HUWE1	23	53618007	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	17643829	53618007	101652553	385	21082											
NHSL2	340527	broad.mit.edu	37	chrX	71359916	71359916	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaggtcggtcagcaagtctGagccggaagatgatattgag	11	9	15	6	2	2	5	1	4	1	1	3	6	2	6	1	3	2	1	1	3	3	2			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chrX:71359916G>C	uc011mqa.1	+	6	2518	c.2518G>C	c.(2518-2520)GAG>CAG	p.E840Q	NHSL2_uc004eak.1_Missense_Mutation_p.E474Q|NHSL2_uc010nli.2_Missense_Mutation_p.E609Q	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	840											0	Renal(35;0.156)					CAGCAAGTCTGAGCCGGAAGA	0.522													7	15					0	0	0	0	C	71359916	C	C	71359916	3	2	116	1	0	0	0	0	1	0	0	0	10466	1291	45	2	2540	2	NHSL2	23	71359916	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	17741909	71359916	83910644	386	21083											
ELF4	2000	broad.mit.edu	37	chrX	129201444	129201444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgtctgcagggtcagggccGagcccgaccccacgggggcc	5	4	16	16	4	2	0	1	0	1	0	3	2	2	0	5	4	2	1	5	4	0	0			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chrX:129201444G>A	uc004evd.3	-	9	1629	c.1244C>T	c.(1243-1245)TCG>TTG	p.S415L	ELF4_uc004eve.3_Missense_Mutation_p.S415L	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	415					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGTCAGGGCCGAGCCCGACCC	0.587			T	ERG	AML								25	38					0	0	0	0	A	129201444	A	A	129201444	3	1	116	1	0	0	0	0	1	0	0	0	5080	1059	37	1	751	1	ELF4	23	129201444	Missense_Mutation	SNP	G	TCGA-CR-5248-01A-01D-2012-08	57841528	129201444	26069116	387	21084											
ARHGEF6	9459	broad.mit.edu	37	chrX	135795499	135795499	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaagttctttagcatattCtttttcagtgtccaggatgt	8	18	8	7	0	3	1	1	1	2	0	4	2	4	2	1	1	1	2	1	1	3	7			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chrX:135795499C>T	uc004fab.2	-	7	1225	c.763G>A	c.(763-765)GAA>AAA	p.E255K	ARHGEF6_uc011mwd.1_Missense_Mutation_p.E128K|ARHGEF6_uc011mwe.1_Missense_Mutation_p.E101K	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	255	DH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					TTAGCATATTCTTTTTCAGTG	0.328													24	28					0	0	0	0	T	135795499	T	T	135795499	3	4	116	1	0	0	0	0	1	0	0	0	910	922	32	2	1631	2	ARHGEF6	23	135795499	Missense_Mutation	SNP	C	TCGA-CR-5248-01A-01D-2012-08	6594055	135795499	19475061	388	21085											
PNCK	139728	broad.mit.edu	37	chrX	152936781	152936781	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcccacacatctacggcCttcccgtagggtttctgctc	6	10	10	15	2	2	0	0	0	2	0	4	0	3	0	3	3	2	3	3	3	2	4			TCGA-CR-5248-01A-01D-2012-08	TCGA-CR-5248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e5af63d7-e8b2-4a76-8b39-6ee652ad8e5f	b9d347d7-5df5-4605-ba32-02b85ae3ecda	g.chrX:152936781C>T	uc011myu.1	-	7	1008	c.822G>A	c.(820-822)AAG>AAA	p.K274K	PNCK_uc011myt.1_Silent_p.K208K|PNCK_uc004fia.2_Silent_p.K226K|PNCK_uc004fhz.3_Silent_p.K89K|PNCK_uc010nuh.2_3'UTR|PNCK_uc011myv.1_3'UTR|PNCK_uc011myw.1_3'UTR	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	pregnancy upregulated non-ubiquitously expressed	191	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CATCTACGGCCTTCCCGTAGG	0.642													4	38					0	0	0	0	T	152936781	T	T	152936781	2	4	116	1	0	0	0	0	0	0	0	1	12200	680	24	4		4	PNCK	23	152936781	Silent	SNP	C	TCGA-CR-5248-01A-01D-2012-08	17141282	152936781	2333779	389	21086											
GPR153	387509	broad.mit.edu	37	chr1	6313858	6313858	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctgcagagaggttttggCgggctccgagccatcgatgg	6	9	17	9	3	1	1	0	0	1	1	3	4	2	1	2	5	2	3	2	5	0	2			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:6313858C>T	uc001amp.1	-	3	966	c.706G>A	c.(706-708)GCC>ACC	p.A236T		NM_207370	NP_997253	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	236	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)		GAGGTTTTGGCGGGCTCCGAG	0.677													3	61					0	0	0	0	T	6313858	T	T	6313858	3	4	117	1	0	0	0	0	1	0	0	0	6697	768	27	1	1139	1	GPR153	1	6313858	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08		6313858	242936763	1	21087											
LHX9	56956	broad.mit.edu	37	chr1	197896796	197896796	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcagaagaccaagcgcaTgcgaacctctttcaagcatc	12	7	8	14	3	2	2	1	0	1	2	4	3	2	2	2	0	4	3	2	0	4	1			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:197896796T>C	uc001guk.1	+	4	1246	c.809T>C	c.(808-810)ATG>ACG	p.M270T	LHX9_uc001gui.1_Missense_Mutation_p.M261T|LHX9_uc001guj.1_Missense_Mutation_p.M276T	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	270	Homeobox.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						ACCAAGCGCATGCGAACCTCT	0.522													9	348					0	0	0	0	C	197896796	C	C	197896796	3	2	117	1	0	0	0	0	1	0	0	0	8818	1464	51	5	855	5	LHX9	1	197896796	Missense_Mutation	SNP	T	TCGA-CR-5249-01A-01D-1512-08	191582938	197896796	51353825	2	21088											
LAX1	54900	broad.mit.edu	37	chr1	203743036	203743038	+	In_Frame_Del	DEL	ACA	-	-																															gcaatgccttccaggagcatAcagcccacatccatgccaca																										TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:203743036_203743038delACA	uc001haa.2	+	5	834_836	c.424_426delACA	c.(424-426)ACAdel	p.T142del	LAX1_uc010pql.1_In_Frame_Del_p.T126del|LAX1_uc001hab.2_In_Frame_Del_p.T66del	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a	142	Cytoplasmic (Potential).				B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCAGGAGCATACAGCCCACATCC	0.527													---	---	---								-	203743038	-	-	203743036	7	5	117	1	0	1	0	1	0	0	0	0	8688	391	14	0	487	0	LAX1	1	203743036	In_Frame_Del	DEL	ACA	TCGA-CR-5249-01A-01D-1512-08	5846240	203743036	45507585	3	21089											
CNTN2	6900	broad.mit.edu	37	chr1	205038678	205038678	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcccccggagagctcatcGtcaactggacggtaagctgc	9	6	13	13	3	2	1	2	0	0	1	3	4	2	2	2	3	5	3	2	3	2	1			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr1:205038678G>A	uc001hbr.2	+	17	2454	c.2185G>A	c.(2185-2187)GTC>ATC	p.V729I	CNTN2_uc001hbq.1_Missense_Mutation_p.V620I|CNTN2_uc001hbs.2_Missense_Mutation_p.V517I	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	729	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGAGCTCATCGTCAACTGGAC	0.612													3	34					0	0	0	0	A	205038678	A	A	205038678	3	1	117	1	0	0	0	0	1	0	0	0	3656	1145	40	1	2247	1	CNTN2	1	205038678	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08	1295642	205038678	44211943	4	21090											
RNASEH1	246243	broad.mit.edu	37	chr2	3608083	3608086	+	5'Flank	DEL	CTTC	-	-																															caaaaccctctctcttccttCttccttccttccttccttcc																								rs66797661		TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr2:3608083_3608086delCTTC	uc002qxs.2	-						RNASEH1_uc002qxt.2_5'Flank|uc002qxu.2_Intron|uc002qxv.2_Intron			O60930	RNH1_HUMAN	SubName: Full=cDNA FLJ39594 fis, clone SKNSH2001875, highly similar to Ribonuclease H1 (EC 3.1.26.4);						RNA catabolic process	cytoplasm	magnesium ion binding|ribonuclease H activity|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0713)|Epithelial(75;0.167)|all cancers(51;0.22)		TCTcttccttcttccttccttcct	0.225													---	---	---								-	3608086	-	-	3608083	6	5	117	0	1	1	0	1	0	0	0	0	13476	928	32	0		0	RNASEH1	2	3608083	5'Flank	DEL	CTTC	TCGA-CR-5249-01A-01D-1512-08		3608083	239591290	5	21091											
EMX1	2016	broad.mit.edu	37	chr2	73161022	73161022	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggctcccatcacatcaaccGgtggcgcattgccacgaagc	9	6	11	15	3	2	0	2	0	0	0	3	1	3	0	3	3	3	2	3	3	2	1			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr2:73161022G>T	uc002sin.1	+	3	1190	c.812G>T	c.(811-813)CGG>CTG	p.R271L	EMX1_uc002sim.1_3'UTR	NM_004097	NP_004088	Q04741	EMX1_HUMAN	empty spiracles homolog 1	238						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CACATCAACCGGTGGCGCATT	0.577													3	84					0.004672	0.00502594	1	0	T	73161022	T	T	73161022	3	4	117	1	0	0	0	0	1	0	0	0	5131	1116	39	3	822	3	EMX1	2	73161022	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08	69552939	73161022	170038351	6	21092											
SNRNP200	23020	broad.mit.edu	37	chr2	96970571	96970571	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccggcgggtccggtcaatGagagaacggtcagcttggag	8	7	16	10	4	2	2	2	1	0	1	4	4	4	3	2	5	2	1	2	5	2	1			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr2:96970571G>A	uc002svu.2	-	2	167	c.81C>T	c.(79-81)CTC>CTT	p.L27L		NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	27						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						TCCGGTCAATGAGAGAACGGT	0.507													22	45					0	0	0	0	A	96970571	A	A	96970571	2	1	117	1	0	0	0	0	0	0	0	1	14916	1277	45	2		2	SNRNP200	2	96970571	Silent	SNP	G	TCGA-CR-5249-01A-01D-1512-08	23809549	96970571	146228802	7	21093											
SLITRK3	22865	broad.mit.edu	37	chr3	164906486	164906486	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccaccaccacctccaccAtcctcaaacagcctgtggca	10	5	5	21	1	1	0	1	0	0	0	3	0	3	0	9	1	2	1	9	1	1	0			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr3:164906486A>G	uc003fej.3	-	2	2577	c.2133T>C	c.(2131-2133)GAT>GAC	p.D711D	SLITRK3_uc003fek.2_Silent_p.D711D	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	711	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						cacctccaccaTCCTCAAACA	0.458										HNSCC(40;0.11)			14	72					0	0	0	0	G	164906486	G	G	164906486	2	3	117	1	0	0	0	0	0	0	0	1	14808	214	8	5		5	SLITRK3	3	164906486	Silent	SNP	A	TCGA-CR-5249-01A-01D-1512-08		164906486	33115944	8	21094											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			139	67					0	0	0	0	A	178936082	A	A	178936082	3	1	117	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08	14029596	178936082	19086348	9	21095											
IQCG	84223	broad.mit.edu	37	chr3	197665623	197665623	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggaagtttgtctagattcGttccttctagattcatttct	7	20	7	7	1	4	2	1	0	3	2	6	3	5	3	1	1	0	2	1	1	3	9			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr3:197665623G>A	uc003fyo.2	-	4	457	c.311C>T	c.(310-312)ACG>ATG	p.T104M	IQCG_uc003fyn.2_Missense_Mutation_p.T6M|IQCG_uc003fyp.2_Missense_Mutation_p.T104M|IQCG_uc003fyq.3_Missense_Mutation_p.T104M	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	104											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		GTCTAGATTCGTTCCTTCTAG	0.358													24	827					0	0	0	0	A	197665623	A	A	197665623	3	1	117	1	0	0	0	0	1	0	0	0	7849	1145	40	1	1052	1	IQCG	3	197665623	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08	18729541	197665623	356807	10	21096											
THAP9	79725	broad.mit.edu	37	chr4	83827690	83827690	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaactacaggatgatcaagAagagaaagggtttacgatta	18	8	11	4	1	1	4	1	1	0	3	1	7	1	5	0	2	3	1	0	2	7	4			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr4:83827690A>G	uc003hnt.2	+	3	609	c.490A>G	c.(490-492)AAG>GAG	p.K164E	THAP9_uc003hns.1_Missense_Mutation_p.K20E|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_5'UTR	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	164							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				GATGATCAAGAAGAGAAAGGG	0.403													49	117					0	0	0	0	G	83827690	G	G	83827690	3	3	117	1	0	0	0	0	1	0	0	0	15917	247	9	5	500	5	THAP9	4	83827690	Missense_Mutation	SNP	A	TCGA-CR-5249-01A-01D-1512-08		83827690	107326586	11	21097											
CCDC110	256309	broad.mit.edu	37	chr4	186379447	186379447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatattctcgttgaagatgcCgcatctcaaattccaaggta	13	12	7	9	2	2	2	1	1	2	1	5	2	3	2	2	1	1	3	2	1	6	5			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr4:186379447C>T	uc003ixu.3	-	6	2370	c.2294G>A	c.(2293-2295)CGG>CAG	p.R765Q	CCDC110_uc003ixv.3_Missense_Mutation_p.R728Q|CCDC110_uc011ckt.1_Missense_Mutation_p.R765Q	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	765	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTGAAGATGCCGCATCTCAAA	0.308													18	46					0	0	0	0	T	186379447	T	T	186379447	3	4	117	1	0	0	0	0	1	0	0	0	2759	652	23	1	215	1	CCDC110	4	186379447	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08	102551757	186379447	4774829	12	21098											
CHD1	1105	broad.mit.edu	37	chr5	98237004	98237004	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaatctgaaccagactgaGatggagatcctgacccagac	13	7	10	11	0	1	7	0	4	1	4	2	9	2	7	3	1	1	0	3	1	2	0			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr5:98237004G>C	uc003knf.2	-	5	621	c.473C>G	c.(472-474)TCT>TGT	p.S158C		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	158					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ACCAGACTGAGATGGAGATCC	0.348													52	176					0	0	0	0	C	98237004	C	C	98237004	3	2	117	1	0	0	0	0	1	0	0	0	3338	942	33	2	4783	2	CHD1	5	98237004	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08		98237004	82678256	13	21099											
C6orf58	352999	broad.mit.edu	37	chr6	127911331	127911331	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcctacaaccttgattagAtcatataagttccagaaggg	13	13	7	8	0	1	3	1	1	0	2	3	3	3	3	3	1	2	1	3	1	6	7			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr6:127911331A>G	uc003qbh.2	+	5	786	c.774A>G	c.(772-774)AGA>AGG	p.R258R		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	258						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		CCTTGATTAGATCATATAAGT	0.408													68	145					0	0	0	0	G	127911331	G	G	127911331	2	3	117	1	0	0	0	0	0	0	0	1	2377	330	12	5		5	C6orf58	6	127911331	Silent	SNP	A	TCGA-CR-5249-01A-01D-1512-08		127911331	43203736	14	21100											
SYNE1	23345	broad.mit.edu	37	chr6	152461285	152461285	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcctggagaagctcccatcGgtcaatcacacctggcaaga	11	6	11	13	1	2	2	2	0	0	2	4	3	3	2	3	4	1	2	3	4	3	0			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr6:152461285G>A	uc010kiw.2	-	140	25860	c.25258C>T	c.(25258-25260)CGA>TGA	p.R8420*	SYNE1_uc010kiv.2_Nonsense_Mutation_p.R2944*|SYNE1_uc003qos.3_Nonsense_Mutation_p.R2944*|SYNE1_uc003qot.3_Nonsense_Mutation_p.R8372*|SYNE1_uc003qou.3_Nonsense_Mutation_p.R8420*|SYNE1_uc003qop.3_Nonsense_Mutation_p.R605*|SYNE1_uc011eez.1_Nonsense_Mutation_p.R622*|SYNE1_uc003qoq.3_Nonsense_Mutation_p.R622*|SYNE1_uc003qor.3_Nonsense_Mutation_p.R1343*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8420	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGCTCCCATCGGTCAATCACA	0.453										HNSCC(10;0.0054)			26	85					0	0	0	0	A	152461285	A	A	152461285	4	1	117	1	0	0	0	0	0	1	0	0	15511	1124	39	1	1163	1	SYNE1	6	152461285	Nonsense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08	24549954	152461285	18653782	15	21101											
DNAH11	8701	broad.mit.edu	37	chr7	21598482	21598482	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtcctgttttacttcacaAgatatggaatatcacataga	13	14	7	7	0	2	2	2	0	0	2	3	3	3	3	1	2	1	1	1	2	6	6			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr7:21598482A>T	uc003svc.2	+	3	589	c.558A>T	c.(556-558)CAA>CAT	p.Q186H		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	186	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TTACTTCACAAGATATGGAAT	0.333									Kartagener_syndrome				4	26					0	0	0	0	T	21598482	T	T	21598482	3	4	117	1	0	0	0	0	1	0	0	0	4621	69	3	5	568	5	DNAH11	7	21598482	Missense_Mutation	SNP	A	TCGA-CR-5249-01A-01D-1512-08		21598482	137540181	16	21102											
FZD1	8321	broad.mit.edu	37	chr7	90895605	90895605	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctgggccaggtggacggCgatgtgctgagcggagtgtg	5	7	21	8	4	0	1	0	1	0	0	0	4	0	3	1	5	2	2	1	5	0	0			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr7:90895605C>T	uc003ula.2	+	1	1823	c.1410C>T	c.(1408-1410)GGC>GGT	p.G470G		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	470	Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			AGGTGGACGGCGATGTGCTGA	0.622													5	209					0	0	0	0	T	90895605	T	T	90895605	2	4	117	1	0	0	0	0	0	0	0	1	6162	755	27	1		1	FZD1	7	90895605	Silent	SNP	C	TCGA-CR-5249-01A-01D-1512-08	69297123	90895605	68243058	17	21103											
C9orf102	375748	broad.mit.edu	37	chr9	98740378	98740378	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcttatattcactcaaacCagaatgtaattggatcgagc	13	12	8	8	1	2	1	2	0	0	1	3	3	2	2	1	2	2	2	1	2	5	5			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr9:98740378C>G	uc004avu.2	+	12	2491	c.1246C>G	c.(1246-1248)CAG>GAG	p.Q416E	uc010msa.1_Missense_Mutation_p.Q106E|uc011lun.1_Missense_Mutation_p.Q106E			Q5T890	RAD26_HUMAN	Homo sapiens cDNA, FLJ97452.	Error:Variant_position_missing_in_Q5T890_after_alignment					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				TCACTCAAACCAGAATGTAAT	0.388													20	67					0	0	0	0	G	98740378	G	G	98740378	3	3	117	1	0	0	0	0	1	0	0	0	2457	609	21	4		4	C9orf102	9	98740378	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08		98740378	42473053	18	21104											
BMS1	9790	broad.mit.edu	37	chr10	43318580	43318580	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtagggaatgtttaattcTgccttggaagtggccaaatt	10	14	11	6	0	1	0	0	0	1	0	1	2	1	2	2	3	1	2	2	3	5	6			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr10:43318580T>A	uc001jaj.2	+	20	3505	c.3147T>A	c.(3145-3147)TCT>TCA	p.S1049S		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	1049					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						TGTTTAATTCTGCCTTGGAAG	0.403													4	165					0	0	0	0	A	43318580	A	A	43318580	2	1	117	1	0	0	0	0	0	0	0	1	1475	1567	55	5		5	BMS1	10	43318580	Silent	SNP	T	TCGA-CR-5249-01A-01D-1512-08		43318580	92216167	19	21105											
HELLS	3070	broad.mit.edu	37	chr10	96348062	96348062	+	Frame_Shift_Del	DEL	T	-	-																															tcctaaacgagaagtagtcgTttatgctccactttcaaaga																										TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr10:96348062delT	uc001kjt.2	+	13	1508	c.1403delT	c.(1402-1404)GTTfs	p.V468fs	HELLS_uc001kjs.2_Frame_Shift_Del_p.V452fs|HELLS_uc009xul.2_Frame_Shift_Del_p.V370fs|HELLS_uc009xum.2_Frame_Shift_Del_p.V338fs|HELLS_uc009xun.2_Frame_Shift_Del_p.V344fs|HELLS_uc009xuo.2_Frame_Shift_Del_p.V514fs|HELLS_uc001kju.2_Frame_Shift_Del_p.V107fs|HELLS_uc009xup.2_RNA|HELLS_uc009xuq.2_Frame_Shift_Del_p.V330fs|HELLS_uc009xur.2_RNA	NM_018063	NP_060533	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	468					cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		GAAGTAGTCGTTTATGCTCCA	0.363													---	---	---								-	96348062	-	-	96348062	7	5	117	1	0	1	0	1	0	0	0	0	7085	1725	60	0	1453	0	HELLS	10	96348062	Frame_Shift_Del	DEL	T	TCGA-CR-5249-01A-01D-1512-08	53029482	96348062	39186685	20	21106											
SORCS1	114815	broad.mit.edu	37	chr10	108448071	108448071	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaatcttcttgttagccAagaacattccctttatccct	9	16	4	12	0	3	1	1	0	2	1	5	1	5	1	3	0	2	1	3	0	5	6			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr10:108448071A>G	uc001kym.2	-	10	1447	c.1439T>C	c.(1438-1440)TTG>TCG	p.L480S	SORCS1_uc001kyl.2_Missense_Mutation_p.L480S|SORCS1_uc009xxs.2_Missense_Mutation_p.L480S|SORCS1_uc001kyn.1_Missense_Mutation_p.L480S|SORCS1_uc001kyo.2_Missense_Mutation_p.L480S	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	480	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTTGTTAGCCAAGAACATTCC	0.403													3	96					0	0	0	0	G	108448071	G	G	108448071	3	3	117	1	0	0	0	0	1	0	0	0	14994	131	5	5	2369	5	SORCS1	10	108448071	Missense_Mutation	SNP	A	TCGA-CR-5249-01A-01D-1512-08	12100009	108448071	27086676	21	21107											
PTPRE	5791	broad.mit.edu	37	chr10	129877950	129877950	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttcagagaccacatatggtGcaaaccctggtaagaatctg	13	9	9	10	0	2	2	1	0	1	2	2	3	2	2	2	2	2	2	2	2	4	3			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr10:129877950G>A	uc001lkb.2	+	20	2298	c.2019G>A	c.(2017-2019)GTG>GTA	p.V673V	PTPRE_uc009yat.2_Silent_p.V684V|PTPRE_uc009yau.2_Silent_p.V673V|PTPRE_uc001lkd.2_Silent_p.V615V|PTPRE_uc010quq.1_Intron	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	673	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				CACATATGGTGCAAACCCTGG	0.383													27	100					0	0	0	0	A	129877950	A	A	129877950	2	1	117	1	0	0	0	0	0	0	0	1	12865	1306	46	4		4	PTPRE	10	129877950	Silent	SNP	G	TCGA-CR-5249-01A-01D-1512-08	21429879	129877950	5656797	22	21108											
KCNA4	3739	broad.mit.edu	37	chr11	30032800	30032800	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatcagaaggcccagttcccGcatgctggctctgagggtgt	7	9	14	11	1	2	2	1	1	1	1	3	3	3	2	2	3	1	4	2	3	1	1			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr11:30032800G>A	uc001msk.2	-	2	2578	c.1426C>T	c.(1426-1428)CGG>TGG	p.R476W		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	476						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCCAGTTCCCGCATGCTGGCT	0.522													8	79					0	0	0	0	A	30032800	A	A	30032800	3	1	117	1	0	0	0	0	1	0	0	0	8044	1086	38	1	539	1	KCNA4	11	30032800	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08		30032800	104973716	23	21109											
OR4A5	81318	broad.mit.edu	37	chr11	51411725	51411725	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccctcttttcctgactgtaaGttttaagggagcttaggatg	8	15	10	8	0	1	1	0	1	1	0	2	3	2	3	2	2	1	3	2	2	3	6			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr11:51411725G>A	uc001nhi.1	-	1	671	c.671C>T	c.(670-672)ACT>ATT	p.T224I		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				CTGACTGTAAGTTTTAAGGGA	0.413													13	102					0	0	0	0	A	51411725	A	A	51411725	3	1	117	1	0	0	0	0	1	0	0	0	11097	1029	36	4	280	4	OR4A5	11	51411725	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08	21378925	51411725	83594791	24	21110											
SLC22A25	387601	broad.mit.edu	37	chr11	62997044	62997044	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatggtatactatgacgttGaacattataaggaaaaccat	16	12	8	5	1	0	3	0	3	0	0	0	4	0	4	1	2	3	2	1	2	8	6			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr11:62997044G>C	uc001nwr.1	-	1	81	c.81C>G	c.(79-81)TTC>TTG	p.F27L	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA|SLC22A25_uc001nwt.1_Missense_Mutation_p.F27L	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	27	Helical; Name=1; (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						CTATGACGTTGAACATTATAA	0.463													5	123					0	0	0	0	C	62997044	C	C	62997044	3	2	117	1	0	0	0	0	1	0	0	0	14518	1281	45	2	1598	2	SLC22A25	11	62997044	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08	11585319	62997044	72009472	25	21111											
SC5DL	6309	broad.mit.edu	37	chr11	121178029	121178029	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagaccaccatatgttcttTgactataattatggacaata	15	13	5	8	0	1	2	0	1	1	1	1	3	1	3	2	1	0	1	2	1	6	7			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr11:121178029T>C	uc001pxu.2	+	5	856	c.708T>C	c.(706-708)TTT>TTC	p.F236F	SC5DL_uc001pxt.2_3'UTR|SC5DL_uc001pxv.2_Silent_p.F236F	NM_006918	NP_008849	O75845	SC5D_HUMAN	sterol-C5-desaturase	236				PQILQPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKN PSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTK TE -> RMKNYSMESLQRLNRLLPSYS (in Ref. 1; BAA18970).	fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	C-5 sterol desaturase activity|iron ion binding|lathosterol oxidase activity			ovary(1)	1		Breast(109;0.00328)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)	OV - Ovarian serous cystadenocarcinoma(1;0.0334)	BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		ATATGTTCTTTGACTATAATT	0.413													10	191					0	0	0	0	C	121178029	C	C	121178029	2	2	117	1	0	0	0	0	0	0	0	1	13931	1809	63	5		5	SC5DL	11	121178029	Silent	SNP	T	TCGA-CR-5249-01A-01D-1512-08	58180985	121178029	13828487	26	21112											
KRT7	3855	broad.mit.edu	37	chr12	52639289	52639289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaggaggagctggaagccGccctgcagcggggcaagcag	10	2	18	11	2	0	0	0	0	0	0	0	3	0	3	2	5	6	5	2	5	2	0			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr12:52639289G>A	uc001saa.1	+	7	1205	c.1078G>A	c.(1078-1080)GCC>ACC	p.A360T	KRT7_uc009zmf.1_Intron	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	360	Rod.|Coil 2.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		GCTGGAAGCCGCCCTGCAGCG	0.652													5	54					0	0	0	0	A	52639289	A	A	52639289	3	1	117	1	0	0	0	0	1	0	0	0	8522	1087	38	1	1104	1	KRT7	12	52639289	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08		52639289	81212606	27	21113											
HECTD1	25831	broad.mit.edu	37	chr14	31602803	31602803	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtttgtccactggcatttttCcccatctgtttaattctcac	6	18	5	12	0	2	0	1	0	2	0	5	0	4	0	3	1	0	3	3	1	1	6			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr14:31602803C>T	uc001wrc.1	-	23	4146	c.3657G>A	c.(3655-3657)GGG>GGA	p.G1219G	HECTD1_uc001wrd.1_Silent_p.G734G	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1219					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TGGCATTTTTCCCCATCTGTT	0.403													27	101					0	0	0	0	T	31602803	T	T	31602803	2	4	117	1	0	0	0	0	0	0	0	1	7078	842	30	2		2	HECTD1	14	31602803	Silent	SNP	C	TCGA-CR-5249-01A-01D-1512-08		31602803	75746737	28	21114											
SAMD4A	23034	broad.mit.edu	37	chr14	55168922	55168922	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatcctggctcactctatTgaacacaaccagcacattga	15	9	5	12	0	2	2	1	2	1	0	3	2	3	2	2	1	3	2	2	1	5	3			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr14:55168922T>C	uc001xbb.2	+	2	337	c.336T>C	c.(334-336)ATT>ATC	p.I112I	SAMD4A_uc001xba.2_Silent_p.I112I|SAMD4A_uc001xbc.2_Silent_p.I112I|SAMD4A_uc001xbf.1_RNA|SAMD4A_uc001xbe.2_Silent_p.I12I	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	113					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						CTCACTCTATTGAACACAACC	0.483													26	88					0	0	0	0	C	55168922	C	C	55168922	2	2	117	1	0	0	0	0	0	0	0	1	13886	1800	63	5		5	SAMD4A	14	55168922	Silent	SNP	T	TCGA-CR-5249-01A-01D-1512-08	23566119	55168922	52180618	29	21115											
TMEM202	338949	broad.mit.edu	37	chr15	72691006	72691006	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtagcctaccgtccctGccaagaaacatccaagtgcc	10	8	7	16	1	0	1	0	0	0	1	2	1	2	1	7	0	5	1	7	0	5	3			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr15:72691006G>A	uc002auq.2	+	2	94	c.94G>A	c.(94-96)GCC>ACC	p.A32T	TMEM202_uc002aur.2_Intron	NM_001080462	NP_001073931	A6NGA9	TM202_HUMAN	transmembrane protein 202	32						integral to membrane				central_nervous_system(1)|skin(1)	2						TACCGTCCCTGCCAAGAAACA	0.532													17	65					0	0	0	0	A	72691006	A	A	72691006	3	1	117	1	0	0	0	0	1	0	0	0	16193	1319	46	4	100	4	TMEM202	15	72691006	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08		72691006	29840386	30	21116											
CACNA1H	8912	broad.mit.edu	37	chr16	1250512	1250512	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccgctcgggtgactccaacCcccacaacggtgccatcaac	9	5	9	18	3	1	1	1	1	0	0	3	1	2	1	5	2	4	1	5	2	3	0			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr16:1250512C>T	uc002cks.2	+	7	1308	c.1060C>T	c.(1060-1062)CCC>TCC	p.P354S	CACNA1H_uc002ckt.2_Missense_Mutation_p.P354S	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	354	Extracellular (Potential).|I.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TGACTCCAACCCCCACAACGG	0.652													3	67					0	0	0	0	T	1250512	T	T	1250512	3	4	117	1	0	0	0	0	1	0	0	0	2557	623	22	4	1082	4	CACNA1H	16	1250512	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08		1250512	89104241	31	21117											
ABCC11	85320	broad.mit.edu	37	chr16	48221269	48221269	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctggtccagctgttccaagtCccctgcgaagcagttcaaaa	10	9	9	13	1	1	0	1	0	0	0	4	1	4	0	4	1	3	4	4	1	4	2			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr16:48221269C>T	uc002eff.1	-	20	3126	c.2776G>A	c.(2776-2778)GAC>AAC	p.D926N	ABCC11_uc002efg.1_Missense_Mutation_p.D926N|ABCC11_uc002efh.1_Missense_Mutation_p.D926N|ABCC11_uc010vgk.1_RNA|ABCC11_uc010cbg.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	926	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TGTTCCAAGTCCCCTGCGAAG	0.527									Cerumen_Type				21	37					0	0	0	0	T	48221269	T	T	48221269	3	4	117	1	0	0	0	0	1	0	0	0	51	855	30	2	1412	2	ABCC11	16	48221269	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08	46970757	48221269	42133484	32	21118											
VPS4A	27183	broad.mit.edu	37	chr16	69349972	69349972	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccaagaactacgaggaggCgctgcggctgtaccagcatg	11	5	14	11	3	0	1	0	0	0	1	0	3	0	2	2	3	6	4	2	3	4	2			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr16:69349972C>T	uc002eww.2	+	2	211	c.83C>T	c.(82-84)GCG>GTG	p.A28V		NM_013245	NP_037377	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting factor 4A	28	Interaction with CHMP1B.|MIT.				cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding				0		Ovarian(137;0.101)				TACGAGGAGGCGCTGCGGCTG	0.577													4	115					0	0	0	0	T	69349972	T	T	69349972	3	4	117	1	0	0	0	0	1	0	0	0	17280	768	27	1	89	1	VPS4A	16	69349972	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08	21128703	69349972	21004781	33	21119											
WWP2	11060	broad.mit.edu	37	chr16	69922039	69922039	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagtgtgaccccgaatccCaacacgacttctctccctgc	8	10	7	16	2	1	2	0	2	1	0	4	4	3	2	4	0	2	0	4	0	2	2			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr16:69922039C>A	uc002exu.1	+	9	890	c.801C>A	c.(799-801)CCC>CCA	p.P267P	WWP2_uc002ext.2_Silent_p.P267P|WWP2_uc002exv.1_Silent_p.P267P|WWP2_uc010vlm.1_Silent_p.P151P	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	267					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						CCCCGAATCCCAACACGACTT	0.617													20	78					4.35082e-09	4.82669e-09	1	0	A	69922039	A	A	69922039	2	1	117	1	0	0	0	0	0	0	0	1	17484	581	21	4		4	WWP2	16	69922039	Silent	SNP	C	TCGA-CR-5249-01A-01D-1512-08	572067	69922039	20432714	34	21120											
CHST6	4166	broad.mit.edu	37	chr16	75512887	75512887	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgcacggatttctgccagCggctcccgcgccaggtcctc	5	7	12	17	5	1	0	0	0	1	0	4	1	3	1	4	3	3	2	4	3	0	1			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr16:75512887C>T	uc002fef.2	-	3	1020	c.840G>A	c.(838-840)CCG>CCA	p.P280P	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.P280P	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	280	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						TTTCTGCCAGCGGCTCCCGCG	0.662													15	49					0	0	0	0	T	75512887	T	T	75512887	2	4	117	1	0	0	0	0	0	0	0	1	3423	755	27	1		1	CHST6	16	75512887	Silent	SNP	C	TCGA-CR-5249-01A-01D-1512-08	5590848	75512887	14841866	35	21121											
SLC13A5	284111	broad.mit.edu	37	chr17	6606290	6606290	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgcgaccaaggactcactCgttcatctggcccaggagca	9	7	12	13	2	3	0	2	0	1	0	4	3	3	2	2	4	2	2	2	4	1	1			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:6606290C>T	uc002gdj.2	-	5	803	c.715G>A	c.(715-717)GAG>AAG	p.E239K	SLC13A5_uc010vtf.1_Missense_Mutation_p.E239K|SLC13A5_uc010clq.2_Missense_Mutation_p.E196K|SLC13A5_uc002gdk.2_Missense_Mutation_p.E222K|SLC13A5_uc002gdl.1_Missense_Mutation_p.E221K	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	239						integral to membrane	citrate transmembrane transporter activity				0						AGGACTCACTCGTTCATCTGG	0.647													22	95					0	0	0	0	T	6606290	T	T	6606290	3	4	117	1	0	0	0	0	1	0	0	0	14460	898	31	1	1023	1	SLC13A5	17	6606290	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08		6606290	74588920	36	21122											
DLX3	1747	broad.mit.edu	37	chr17	48070809	48070809	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcggccagctcggcgcgctcGggcagcgccaggtactgggc	4	4	18	15	6	0	0	0	0	0	0	2	0	0	0	2	5	3	4	2	5	1	1			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:48070809G>A	uc002ipy.2	-	2	697	c.471C>T	c.(469-471)CCC>CCT	p.P157P		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	157	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGGCGCGCTCGGGCAGCGCCA	0.706													7	22					0	0	0	0	A	48070809	A	A	48070809	2	1	117	1	0	0	0	0	0	0	0	1	4594	1103	39	1		1	DLX3	17	48070809	Silent	SNP	G	TCGA-CR-5249-01A-01D-1512-08	41464519	48070809	33124401	37	21123											
GRIN2C	2905	broad.mit.edu	37	chr17	72840467	72840467	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagttgggcaccgagtggCgcagcttccagtagaccagg	9	7	15	10	2	0	2	0	1	0	1	1	3	1	2	3	3	1	5	3	3	1	3			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:72840467C>T	uc002jlt.1	-	12	2687	c.2531G>A	c.(2530-2532)CGC>CAC	p.R844H	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.R844H	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	844	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CACCGAGTGGCGCAGCTTCCA	0.617													4	110					0	0	0	0	T	72840467	T	T	72840467	3	4	117	1	0	0	0	0	1	0	0	0	6820	768	27	1	1178	1	GRIN2C	17	72840467	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08	24769658	72840467	8354743	38	21124											
SLC26A11	284129	broad.mit.edu	37	chr17	78195395	78195395	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acggcgctgggtcaggccagGtcctctggccccgggatggc	4	6	17	14	3	2	0	1	0	1	0	3	1	3	1	4	7	0	1	4	7	0	0			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr17:78195395G>T	uc002jyb.1	+	3	305	c.36G>T	c.(34-36)AGG>AGT	p.R12S	SGSH_uc002jxz.3_5'Flank|SGSH_uc002jya.3_5'Flank|SGSH_uc002jxy.2_5'Flank|SGSH_uc010wue.1_5'Flank|SLC26A11_uc002jyc.1_Missense_Mutation_p.R12S|SLC26A11_uc002jyd.1_Missense_Mutation_p.R12S|SLC26A11_uc010dhv.1_Missense_Mutation_p.R12S	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	12	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GTCAGGCCAGGTCCTCTGGCC	0.687													7	19					0.00621372	0.00658468	1	0	T	78195395	T	T	78195395	3	4	117	1	0	0	0	0	1	0	0	0	14580	1252	44	4	38	4	SLC26A11	17	78195395	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08	5354928	78195395	2999815	39	21125											
KIAA0802	23255	broad.mit.edu	37	chr18	8825333	8825333	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccccactgcacagcctggaGatgtccaagaacttgagtga	11	8	10	12	0	0	4	0	2	0	2	2	5	2	4	4	1	3	1	4	1	2	1			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr18:8825333G>A	uc002knr.2	+	15	3967	c.3825G>A	c.(3823-3825)GAG>GAA	p.E1275E	KIAA0802_uc002knq.2_Silent_p.E1234E|KIAA0802_uc002kns.2_Silent_p.E615E	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1585											0						ACAGCCTGGAGATGTCCAAGA	0.617													20	51					0	0	0	0	A	8825333	A	A	8825333	2	1	117	1	0	0	0	0	0	0	0	1	8233	933	33	2		2	KIAA0802	18	8825333	Silent	SNP	G	TCGA-CR-5249-01A-01D-1512-08		8825333	69251915	40	21126											
PNPLA6	10908	broad.mit.edu	37	chr19	7605584	7605584	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacagccttctcagcatcctGgatgtcatcaccgtgagtga	10	10	9	12	1	3	2	3	2	1	0	5	3	4	3	3	1	3	1	3	1	1	1			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:7605584G>A	uc010xjq.1	+	8	1005	c.810G>A	c.(808-810)CTG>CTA	p.L270L	PNPLA6_uc002mgq.1_Silent_p.L222L|PNPLA6_uc010xjp.1_Silent_p.L222L|PNPLA6_uc002mgr.1_Silent_p.L222L|PNPLA6_uc002mgs.2_Silent_p.L261L	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	261	cNMP 1.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						TCAGCATCCTGGATGTCATCA	0.587													5	127					0	0	0	0	A	7605584	A	A	7605584	2	1	117	1	0	0	0	0	0	0	0	1	12224	1335	47	4		4	PNPLA6	19	7605584	Silent	SNP	G	TCGA-CR-5249-01A-01D-1512-08		7605584	51523399	41	21127											
ILF3	3609	broad.mit.edu	37	chr19	10793296	10793296	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcggctgaggagaccgaggcGaagccagcagtggtggcccc	8	4	17	12	3	0	2	0	1	0	1	1	5	0	2	4	5	2	2	4	5	1	0			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:10793296G>A	uc002mpn.2	+	13	1781	c.1464G>A	c.(1462-1464)GCG>GCA	p.A488A	ILF3_uc002mpm.2_Silent_p.A488A|ILF3_uc002mpl.2_Silent_p.A488A|ILF3_uc002mpk.2_Silent_p.A488A|ILF3_uc010xli.1_Silent_p.A86A|ILF3_uc002mpo.2_Silent_p.A488A|ILF3_uc002mpp.2_Silent_p.A309A	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	488					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			AGACCGAGGCGAAGCCAGCAG	0.642													6	51					0	0	0	0	A	10793296	A	A	10793296	2	1	117	1	0	0	0	0	0	0	0	1	7751	1045	37	1		1	ILF3	19	10793296	Silent	SNP	G	TCGA-CR-5249-01A-01D-1512-08	3187712	10793296	48335687	42	21128											
QTRT1	81890	broad.mit.edu	37	chr19	10823854	10823854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgcttcccggacttcgtgCgggacttcatgggcgccatg	5	9	14	13	5	1	0	1	0	0	0	3	2	2	2	2	3	2	1	2	3	0	3			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:10823854C>T	uc002mpr.2	+	10	1145	c.1120C>T	c.(1120-1122)CGG>TGG	p.R374W	DNM2_uc010dxk.2_RNA	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	374					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			GGACTTCGTGCGGGACTTCAT	0.657													20	97					0	0	0	0	T	10823854	T	T	10823854	3	4	117	1	0	0	0	0	1	0	0	0	12950	759	27	1	1158	1	QTRT1	19	10823854	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08	30558	10823854	48305129	43	21129											
CACNA1A	773	broad.mit.edu	37	chr19	13368242	13368242	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatgatcaaggccacaaaGatattgacaaagaagaaggg	19	6	11	5	0	1	6	1	3	0	3	1	6	1	6	1	2	0	0	1	2	6	2			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:13368242G>T	uc010dze.2	-	28	4751	c.4515C>A	c.(4513-4515)ATC>ATA	p.I1505I	CACNA1A_uc010xnd.1_Silent_p.I210I|CACNA1A_uc002mwx.3_Silent_p.I210I|CACNA1A_uc010dzc.2_Silent_p.I1030I|CACNA1A_uc002mwy.3_Silent_p.I1504I|CACNA1A_uc010xne.1_Silent_p.I1033I|CACNA1A_uc002mwv.3_Silent_p.I21I	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1505	III.|Helical; Name=S6 of repeat III; (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AGGCCACAAAGATATTGACAA	0.502													14	31					2.61681e-11	2.94911e-11	1	0	T	13368242	T	T	13368242	2	4	117	1	0	0	0	0	0	0	0	1	2550	932	33	2		2	CACNA1A	19	13368242	Silent	SNP	G	TCGA-CR-5249-01A-01D-1512-08	2544388	13368242	45760741	44	21130											
ZNF569	148266	broad.mit.edu	37	chr19	37904081	37904081	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacattcattgcattcataGggtttctctccagaatgaat	11	14	6	10	0	3	2	2	1	1	1	5	2	4	2	2	1	1	2	2	1	3	5			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:37904081G>T	uc002ogi.2	-	6	2037	c.1479C>A	c.(1477-1479)CCC>CCA	p.P493P	ZNF569_uc002ogh.2_Silent_p.P334P|ZNF569_uc002ogj.2_Silent_p.P517P	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	493					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGCATTCATAGGGTTTCTCTC	0.353													31	92					2.65835e-16	3.04424e-16	1	0	T	37904081	T	T	37904081	2	4	117	1	0	0	0	0	0	0	0	1	18067	987	35	4		4	ZNF569	19	37904081	Silent	SNP	G	TCGA-CR-5249-01A-01D-1512-08	24535839	37904081	21224902	45	21131											
GYS1	2997	broad.mit.edu	37	chr19	49494659	49494659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacgccctgctccgtgtacGgccccaccaggaagtagttg	7	8	11	15	3	1	0	1	0	0	0	2	1	2	1	5	2	2	4	5	2	3	3			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:49494659G>A	uc002plp.2	-	2	441	c.200C>T	c.(199-201)CCG>CTG	p.P67L	GYS1_uc010xzy.1_Intron|GYS1_uc010emm.2_Missense_Mutation_p.P67L|GYS1_uc010xzz.1_Intron|GYS1_uc010yaa.1_Intron|RUVBL2_uc002plq.1_5'Flank|RUVBL2_uc010yab.1_5'Flank|RUVBL2_uc002plr.1_5'Flank|RUVBL2_uc002pls.1_5'Flank|RUVBL2_uc010emn.1_5'Flank	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	67					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		CTCCGTGTACGGCCCCACCAG	0.637													6	291					0	0	0	0	A	49494659	A	A	49494659	3	1	117	1	0	0	0	0	1	0	0	0	6951	1116	39	1	2073	1	GYS1	19	49494659	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08	11590578	49494659	9634324	46	21132											
ZNF320	162967	broad.mit.edu	37	chr19	53367199	53367199	+	RNA	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acatcaaaagcacgtatgggGcaaaatcacaaaagagaata	21	5	8	7	1	2	1	2	0	0	1	2	2	2	1	0	2	1	3	0	2	9	2			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr19:53367199G>A	uc010eqh.1	-	3		c.478C>T			ZNF320_uc010eqi.1_RNA			A2RRD8	ZN320_HUMAN	Homo sapiens full length insert cDNA clone ZD42C02.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		CACGTATGGGGCAAAATCACA	0.269													3	38					0	0	0	0	A	53367199	A	A	53367199	1	1	117	0	1	0	0	0	0	0	0	0	17906	1218	42	4		4	ZNF320	19	53367199	RNA	SNP	G	TCGA-CR-5249-01A-01D-1512-08	3872540	53367199	5761784	47	21133											
ZNF337	26152	broad.mit.edu	37	chr20	25657231	25657232	+	Frame_Shift_Del	DEL	TG	-	-																															cacacataggacttctctccTgtgtgtgtgttctggtgcaa																										TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr20:25657231_25657232delTG	uc002wva.2	-	4	1214_1215	c.692_693delCA	c.(691-693)ACAfs	p.T231fs	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Frame_Shift_Del_p.T199fs|ZNF337_uc002wvb.2_Frame_Shift_Del_p.T231fs|ZNF337_uc002wvc.2_Frame_Shift_Del_p.T231fs	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	231					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTTCTCTCCTGTGTGTGTGTT	0.51													---	---	---								-	25657232	-	-	25657231	7	5	117	1	0	1	0	1	0	0	0	0	17920	1567	55	0	1566	0	ZNF337	20	25657231	Frame_Shift_Del	DEL	TG	TCGA-CR-5249-01A-01D-1512-08		25657231	37368289	48	21134											
NCOA6	23054	broad.mit.edu	37	chr20	33345055	33345055	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtaaactctgtggccccTggtttggtggttgctgctgc	4	14	14	9	0	1	0	0	0	1	0	1	1	1	0	2	4	4	5	2	4	2	3			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr20:33345055T>C	uc002xav.2	-	8	4067	c.1496A>G	c.(1495-1497)CAG>CGG	p.Q499R	NCOA6_uc002xaw.2_Missense_Mutation_p.Q499R|NCOA6_uc010gew.1_Missense_Mutation_p.Q456R	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	499	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CTGTGGCCCCTGGTTTGGTGG	0.488													6	273					0	0	0	0	C	33345055	C	C	33345055	3	2	117	1	0	0	0	0	1	0	0	0	10287	1580	55	5	4731	5	NCOA6	20	33345055	Missense_Mutation	SNP	T	TCGA-CR-5249-01A-01D-1512-08	7687824	33345055	29680465	49	21135											
KCNB1	3745	broad.mit.edu	37	chr20	48098552	48098552	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcctcgccttcccgctcccGtagggtctcggcctcacgct	2	10	9	20	5	2	0	1	0	1	0	7	0	5	0	5	2	0	3	5	2	1	2			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr20:48098552G>A	uc002xur.1	-	1	630	c.466C>T	c.(466-468)CGG>TGG	p.R156W	KCNB1_uc002xus.1_Missense_Mutation_p.R156W	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	156	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCCCGCTCCCGTAGGGTCTCG	0.582													46	117					0	0	0	0	A	48098552	A	A	48098552	3	1	117	1	0	0	0	0	1	0	0	0	8051	1144	40	1	2118	1	KCNB1	20	48098552	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08	14753497	48098552	14926968	50	21136											
ZGPAT	84619	broad.mit.edu	37	chr20	62340307	62340307	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaggaagagggagaggaCgaggaagagctgagtgggac	14	2	22	3	1	0	4	0	1	0	3	0	12	0	9	0	6	1	1	0	6	2	0			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr20:62340307C>T	uc002ygk.2	+	2	553	c.375C>T	c.(373-375)GAC>GAT	p.D125D	ARFRP1_uc002yga.2_5'Flank|ARFRP1_uc002ygc.2_5'Flank|ARFRP1_uc002ygh.3_5'Flank|ARFRP1_uc011abf.1_5'Flank|ARFRP1_uc011abg.1_5'Flank|ARFRP1_uc002yge.2_5'Flank|ARFRP1_uc002ygd.2_5'Flank|ARFRP1_uc002ygf.2_5'Flank|ARFRP1_uc002ygg.2_5'Flank|ARFRP1_uc011abh.1_5'Flank|ZGPAT_uc002ygi.2_Silent_p.D125D|ZGPAT_uc002ygj.2_Silent_p.D125D|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Silent_p.D125D|ZGPAT_uc002ygm.2_Silent_p.D125D|ZGPAT_uc002ygn.3_RNA	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	125	Poly-Glu.				negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					agggagaggacgaggaagagC	0.542													5	70					0	0	0	0	T	62340307	T	T	62340307	2	4	117	1	0	0	0	0	0	0	0	1	17741	535	19	1		1	ZGPAT	20	62340307	Silent	SNP	C	TCGA-CR-5249-01A-01D-1512-08	14241755	62340307	685213	51	21137											
ABCG1	9619	broad.mit.edu	37	chr21	43708124	43708124	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgccgaggtgaacccttttCtttggcaccggccctctgaa	7	11	10	13	2	2	2	0	2	2	0	2	3	2	2	4	3	2	1	4	3	2	3			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chr21:43708124C>G	uc002zaq.2	+	9	1205	c.1099C>G	c.(1099-1101)CTT>GTT	p.L367V	ABCG1_uc002zan.2_Missense_Mutation_p.L369V|ABCG1_uc002zam.2_Missense_Mutation_p.L345V|ABCG1_uc002zao.2_Missense_Mutation_p.L364V|ABCG1_uc002zap.2_Missense_Mutation_p.L367V|ABCG1_uc002zar.2_Missense_Mutation_p.L378V|ABCG1_uc011aev.1_Missense_Mutation_p.L378V|ABCG1_uc010gpb.1_5'UTR	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	367	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	GAACCCTTTTCTTTGGCACCG	0.567													17	238					0	0	0	0	G	43708124	G	G	43708124	3	3	117	1	0	0	0	0	1	0	0	0	68	913	32	2	1301	2	ABCG1	21	43708124	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08		43708124	4421771	52	21138											
PDHA1	5160	broad.mit.edu	37	chrX	19369427	19369427	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgtgtgggcctggaggccgGcatcaaccccacagaccatc	8	6	12	15	1	1	1	1	0	0	1	2	2	1	2	5	4	1	1	5	4	1	0			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chrX:19369427G>A	uc004czg.3	+	4	465	c.320G>A	c.(319-321)GGC>GAC	p.G107D	PDHA1_uc004czh.3_Missense_Mutation_p.G142D|PDHA1_uc011mjc.1_Missense_Mutation_p.G111D|PDHA1_uc011mjd.1_Missense_Mutation_p.G104D|PDHA1_uc010nfk.2_Missense_Mutation_p.G104D	NM_000284	NP_000275	P08559	ODPA_HUMAN	pyruvate dehydrogenase E1 alpha 1 precursor	107					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)	1	Hepatocellular(33;0.183)				NADH(DB00157)	CTGGAGGCCGGCATCAACCCC	0.507													6	222					0	0	0	0	A	19369427	A	A	19369427	3	1	117	1	0	0	0	0	1	0	0	0	11718	1203	42	4	473	4	PDHA1	23	19369427	Missense_Mutation	SNP	G	TCGA-CR-5249-01A-01D-1512-08		19369427	135901133	53	21139											
PCDH11X	27328	broad.mit.edu	37	chrX	91642836	91642836	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagccttaccagcacatctCatggcctgccccttggctat	7	10	8	16	0	1	0	1	0	1	0	2	0	1	0	5	2	4	3	5	2	2	3			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chrX:91642836C>G	uc004efk.1	+	5	4092	c.3247C>G	c.(3247-3249)CAT>GAT	p.H1083D	PCDH11X_uc004efl.1_Missense_Mutation_p.H1073D|PCDH11X_uc004efo.1_Missense_Mutation_p.H1046D|PCDH11X_uc010nmv.1_Intron|PCDH11X_uc004efm.1_Missense_Mutation_p.H1083D|PCDH11X_uc004efn.1_Missense_Mutation_p.H1073D	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1083	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CAGCACATCTCATGGCCTGCC	0.552													38	134					0	0	0	0	G	91642836	G	G	91642836	3	3	117	1	0	0	0	0	1	0	0	0	11562	826	29	2	3387	2	PCDH11X	23	91642836	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08	72273409	91642836	63627724	54	21140											
WDR44	54521	broad.mit.edu	37	chrX	117532358	117532358	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttcttacagtaatgacgCggcacagtcagatgatgaag	12	9	10	10	2	2	4	1	3	1	1	2	4	2	4	1	1	1	2	1	1	3	3			TCGA-CR-5249-01A-01D-1512-08	TCGA-CR-5249-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	42bf9ca3-47d8-45ff-bccf-bda80af58d22	25a6fe65-a78b-4adc-8ce7-1bc2bc4bbf48	g.chrX:117532358C>T	uc004eqn.2	+	8	1624	c.1199C>T	c.(1198-1200)GCG>GTG	p.A400V	WDR44_uc004eqo.2_Missense_Mutation_p.A400V|WDR44_uc011mtr.1_Missense_Mutation_p.A375V|WDR44_uc010nqi.2_Missense_Mutation_p.A110V	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	400						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						AGTAATGACGCGGCACAGTCA	0.358													36	95					0	0	0	0	T	117532358	T	T	117532358	3	4	117	1	0	0	0	0	1	0	0	0	17364	768	27	1	1229	1	WDR44	23	117532358	Missense_Mutation	SNP	C	TCGA-CR-5249-01A-01D-1512-08	25889522	117532358	37738202	55	21141											
SLC4A1AP	22950	broad.mit.edu	37	chr2	27886558	27886558	+	Translation_Start_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcccgttgtaacctctaaatAtgtccccgttctgcacagca	9	12	6	14	2	2	0	0	0	2	0	4	0	4	0	4	0	3	5	4	0	4	5			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:27886558A>G	uc002rlk.3	+	1	221	c.-61A>G	c.(-63--59)ATATG>ATGTG		SUPT7L_uc002rlh.1_5'Flank|SUPT7L_uc002rli.1_5'Flank|SUPT7L_uc010ymf.1_5'Flank|SUPT7L_uc002rlj.1_5'Flank|SUPT7L_uc010ezh.1_5'Flank	NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),							cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					ACCTCTAAATATGTCCCCGTT	0.458													30	58					0	0	0	0	G	27886558	G	G	27886558	1	3	118	1	0	0	0	0	0	0	0	0	14717	464	16	5		5	SLC4A1AP	2	27886558	Translation_Start_Site	SNP	A	TCGA-CR-5250-01A-01D-1512-08		27886558	215312815	1	21142											
SPTBN1	6711	broad.mit.edu	37	chr2	54844759	54844759	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggcaggtaccccaatgtcaAcattcacaatttcaccacta	13	10	5	13	0	3	0	3	0	0	0	3	0	3	0	3	2	2	2	3	2	5	4			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:54844759A>G	uc002rxu.2	+	6	830	c.581A>G	c.(580-582)AAC>AGC	p.N194S	SPTBN1_uc002rxv.1_Missense_Mutation_p.N194S|SPTBN1_uc002rxx.2_Missense_Mutation_p.N181S	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	194	CH 2.|Actin-binding.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CCCAATGTCAACATTCACAAT	0.438													19	39					0	0	0	0	G	54844759	G	G	54844759	3	3	118	1	0	0	0	0	1	0	0	0	15185	43	2	5	712	5	SPTBN1	2	54844759	Missense_Mutation	SNP	A	TCGA-CR-5250-01A-01D-1512-08	26958201	54844759	188354614	2	21143											
THSD7B	80731	broad.mit.edu	37	chr2	137814582	137814582	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatatacatttagccttaaGgttggaccatggagtaaatg	14	12	10	5	0	0	0	0	0	0	0	0	3	0	2	2	3	2	2	2	3	7	7			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:137814582G>T	uc002tva.1	+	2	639	c.639G>T	c.(637-639)AAG>AAT	p.K213N	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.K103N	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTAGCCTTAAGGTTGGACCAT	0.423													86	190					8.6838e-40	9.95019e-40	1	0	T	137814582	T	T	137814582	3	4	118	1	0	0	0	0	1	0	0	0	15946	991	35	4	645	4	THSD7B	2	137814582	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08	82969823	137814582	105384791	3	21144											
XIRP2	129446	broad.mit.edu	37	chr2	168106779	168106779	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaactgcaacagattttgtcGagagtgaaacagtttgaagc	14	10	11	6	1	0	4	0	2	0	2	1	6	0	4	0	0	5	2	0	0	4	3			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:168106779G>A	uc002udx.2	+	8	8895	c.8877G>A	c.(8875-8877)TCG>TCA	p.S2959S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.S2784S|XIRP2_uc010fpq.2_Silent_p.S2737S|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Silent_p.S305S	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2784	Potential.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGATTTTGTCGAGAGTGAAAC	0.383													74	135					0	0	0	0	A	168106779	A	A	168106779	2	1	118	1	0	0	0	0	0	0	0	1	17498	1045	37	1		1	XIRP2	2	168106779	Silent	SNP	G	TCGA-CR-5250-01A-01D-1512-08	30292197	168106779	75092594	4	21145											
WIPF1	7456	broad.mit.edu	37	chr2	175446127	175446127	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggagagcatttctcccaGcctgctctgtcttattcaag	10	12	8	11	0	4	1	1	0	3	1	5	2	4	1	2	1	3	2	2	1	3	3			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:175446127G>C	uc002uiy.2	-	4	424	c.92C>G	c.(91-93)GCT>GGT	p.A31G	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.A31G|WIPF1_uc010fqt.1_Missense_Mutation_p.A31G|WIPF1_uc002ujc.1_Missense_Mutation_p.A31G|WIPF1_uc002uiz.2_Missense_Mutation_p.A31G|WIPF1_uc002ujb.1_Missense_Mutation_p.A31G|WIPF1_uc010zep.1_Missense_Mutation_p.A31G	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	31					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						ATTTCTCCCAGCCTGCTCTGT	0.418													118	198					0	0	0	0	C	175446127	C	C	175446127	3	2	118	1	0	0	0	0	1	0	0	0	17435	971	34	4	1443	4	WIPF1	2	175446127	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08	7339348	175446127	67753246	5	21146											
TTN	7273	broad.mit.edu	37	chr2	179401254	179401254	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggccacaacacaagaaTcttttgtgacagcagtaata	15	9	7	10	0	1	2	0	1	1	1	2	2	2	2	2	1	2	2	2	1	5	4			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:179401254T>C	uc010zfg.1	-	306	92740	c.92516A>G	c.(92515-92517)GAT>GGT	p.D30839G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D24534G|TTN_uc010zfi.1_Missense_Mutation_p.D24467G|TTN_uc010zfj.1_Missense_Mutation_p.D24342G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31766							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACACAAGAATCTTTTGTGAC	0.403													46	92					0	0	0	0	C	179401254	C	C	179401254	3	2	118	1	0	0	0	0	1	0	0	0	16803	1435	50	5	7783	5	TTN	2	179401254	Missense_Mutation	SNP	T	TCGA-CR-5250-01A-01D-1512-08	3955127	179401254	63798119	6	21147											
VGLL4	9686	broad.mit.edu	37	chr3	11600120	11600120	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgagaggcggactcagggctGctggatgctccgtccttggc	5	8	16	12	3	1	1	1	0	0	1	3	4	3	3	2	5	2	3	2	5	0	1			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr3:11600120G>A	uc003bwf.2	-	6	1149	c.783C>T	c.(781-783)AGC>AGT	p.S261S	VGLL4_uc010hdx.1_Silent_p.S267S|VGLL4_uc003bwg.2_Silent_p.S266S|VGLL4_uc010hdv.1_Silent_p.S177S|VGLL4_uc010hdw.1_Silent_p.S181S|VGLL4_uc011aun.1_Silent_p.S202S	NM_014667	NP_055482	Q14135	VGLL4_HUMAN	vestigial like 4 isoform b	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		ACTCAGGGCTGCTGGATGCTC	0.657													33	64					0	0	0	0	A	11600120	A	A	11600120	2	1	118	1	0	0	0	0	0	0	0	1	17229	1310	46	4		4	VGLL4	3	11600120	Silent	SNP	G	TCGA-CR-5250-01A-01D-1512-08		11600120	186422310	7	21148											
ALS2CL	259173	broad.mit.edu	37	chr3	46725326	46725326	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcttcttcgggcgtgaggagGtgaaacgtgcacctagacag	9	9	14	9	3	2	3	0	2	2	1	3	4	2	4	1	3	2	1	1	3	2	3			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr3:46725326G>C	uc003cqa.1	-	9	1048	c.858C>G	c.(856-858)CAC>CAG	p.H286Q	ALS2CL_uc003cpz.1_5'Flank|ALS2CL_uc003cqb.1_Missense_Mutation_p.H286Q|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	286					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GCGTGAGGAGGTGAAACGTGC	0.617													65	62					0	0	0	0	C	46725326	C	C	46725326	3	2	118	1	0	0	0	0	1	0	0	0	551	1252	44	4	2075	4	ALS2CL	3	46725326	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08	35125206	46725326	151297104	8	21149											
PDE12	201626	broad.mit.edu	37	chr3	57543283	57543283	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accgaaagtctaagttcagcCttcttagccagcatgacatt	12	11	7	11	1	3	1	1	1	2	0	3	2	3	1	3	0	3	2	3	0	3	5			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr3:57543283C>T	uc003diw.3	+	1	1303	c.1177C>T	c.(1177-1179)CTT>TTT	p.L393F	PDE12_uc003div.2_Missense_Mutation_p.L393F	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	393							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		TAAGTTCAGCCTTCTTAGCCA	0.532													34	21					0	0	0	0	T	57543283	T	T	57543283	3	4	118	1	0	0	0	0	1	0	0	0	11686	681	24	4	1179	4	PDE12	3	57543283	Missense_Mutation	SNP	C	TCGA-CR-5250-01A-01D-1512-08	10817957	57543283	140479147	9	21150											
TRA2B	6434	broad.mit.edu	37	chr3	185655648	185655648	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctcgccgctgtcgctcaTgactcctggctgctgtcgcc	2	11	11	17	4	1	1	1	1	0	0	5	1	2	1	3	1	2	5	3	1	0	0			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr3:185655648T>C	uc003fpv.2	-	1	277	c.1A>G	c.(1-3)ATG>GTG	p.M1V	TRA2B_uc003fpu.2_5'Flank|TRA2B_uc010hym.2_5'UTR|TRA2B_uc003fpw.2_Missense_Mutation_p.M1V|TRA2B_uc003fpx.2_RNA	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	1					nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2						CTGTCGCTCATGACTCCTGGC	0.632													26	37					0	0	0	0	C	185655648	C	C	185655648	3	2	118	1	0	0	0	0	1	0	0	0	16501	1464	51	5	901	5	TRA2B	3	185655648	Missense_Mutation	SNP	T	TCGA-CR-5250-01A-01D-1512-08	128112365	185655648	12366782	10	21151											
ACOX3	8310	broad.mit.edu	37	chr4	8376858	8376858	+	Frame_Shift_Del	DEL	C	-	-																															gagctccacgaaggccagcgCcaacggacggccgtgggaca																										TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr4:8376858delC	uc010idk.2	-	15	1820	c.1675delG	c.(1675-1677)GCGfs	p.A559fs	ACOX3_uc003glc.3_Frame_Shift_Del_p.A559fs|ACOX3_uc003gld.3_Frame_Shift_Del_p.A559fs|ACOX3_uc003gle.1_Frame_Shift_Del_p.A464fs	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	559					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						AAGGCCAGCGCCAACGGACGG	0.697													---	---	---								-	8376858	-	-	8376858	7	5	118	1	0	1	0	1	0	0	0	0	160	739	26	0	443	0	ACOX3	4	8376858	Frame_Shift_Del	DEL	C	TCGA-CR-5250-01A-01D-1512-08		8376858	182777418	11	21152											
UGT2B11	10720	broad.mit.edu	37	chr4	70079789	70079789	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaccaaaagtcaaaataaaGcacatagatcatatttttta	20	11	4	6	0	2	1	2	0	0	1	2	2	2	1	1	0	2	1	1	0	10	6			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr4:70079789G>T	uc003heh.2	-	1	661	c.652C>A	c.(652-654)CTT>ATT	p.L218I	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	218					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						TCAAAATAAAGCACATAGATC	0.338													31	96					4.65686e-17	4.92553e-17	1	0	T	70079789	T	T	70079789	3	4	118	1	0	0	0	0	1	0	0	0	17025	971	34	4	961	4	UGT2B11	4	70079789	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08	61702931	70079789	121074487	12	21153											
ODZ2	57451	broad.mit.edu	37	chr5	167645514	167645514	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagatgatgcctacgcgactGatgccatcttgaattcccca	10	10	9	12	2	1	4	0	3	1	1	2	6	2	4	4	0	3	0	4	0	2	3			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr5:167645514G>C	uc010jjd.2	+	23	4591	c.4591G>C	c.(4591-4593)GAT>CAT	p.D1531H	ODZ2_uc003lzr.3_Missense_Mutation_p.D1301H|ODZ2_uc003lzt.3_Missense_Mutation_p.D904H|ODZ2_uc010jje.2_Missense_Mutation_p.D795H	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CTACGCGACTGATGCCATCTT	0.498													86	212					0	0	0	0	C	167645514	C	C	167645514	3	2	118	1	0	0	0	0	1	0	0	0	10889	1290	45	2	4681	2	ODZ2	5	167645514	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08		167645514	13269746	13	21154											
RASGEF1C	255426	broad.mit.edu	37	chr5	179545821	179545821	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acttggccgtcctcactttgGcccaggtcttcttcagcctg	4	13	9	15	1	4	0	2	0	2	0	5	0	5	0	4	3	1	0	4	3	0	4			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr5:179545821G>T	uc003mlq.2	-	8	1250	c.953C>A	c.(952-954)GCC>GAC	p.A318D	RASGEF1C_uc003mlr.2_Missense_Mutation_p.A318D|RASGEF1C_uc003mlp.3_Missense_Mutation_p.A167D	NM_175062	NP_778232	Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	318	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTCACTTTGGCCCAGGTCTT	0.627													52	87					3.17154e-08	3.23028e-08	1	0	T	179545821	T	T	179545821	3	4	118	1	0	0	0	0	1	0	0	0	13136	1203	42	4	471	4	RASGEF1C	5	179545821	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08	11900307	179545821	1369439	14	21155											
KCNK16	83795	broad.mit.edu	37	chr6	39284101	39284101	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagccagagctggcagcatCtgtgcagaagcagggggccc	9	4	16	12	0	1	2	0	0	1	2	1	2	1	2	2	3	5	6	2	3	1	0			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr6:39284101C>T	uc003ooq.2	-	5	793	c.779G>A	c.(778-780)AGA>AAA	p.R260K	KCNK17_uc003ooo.2_5'Flank|KCNK17_uc003oop.2_5'Flank|KCNK16_uc003oor.3_Intron|KCNK16_uc010jwy.2_Intron|KCNK16_uc011dtz.1_Missense_Mutation_p.R260K	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	260	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						CTGGCAGCATCTGTGCAGAAG	0.637													10	20					0	0	0	0	T	39284101	T	T	39284101	3	4	118	1	0	0	0	0	1	0	0	0	8102	913	32	2	543	2	KCNK16	6	39284101	Missense_Mutation	SNP	C	TCGA-CR-5250-01A-01D-1512-08		39284101	131830966	15	21156											
RAC1	5879	broad.mit.edu	37	chr7	6426860	6426860	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagagctgtaggtaaaacttGcctactgatcagttacacaa	14	11	8	8	0	1	2	1	1	0	1	1	2	1	2	1	1	5	4	1	1	7	6			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr7:6426860G>T	uc003spx.2	+	2	294	c.53G>T	c.(52-54)TGC>TTC	p.C18F	RAC1_uc003spw.2_Missense_Mutation_p.C18F	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	18					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	GGTAAAACTTGCCTACTGATC	0.338													38	115					1.15505e-17	1.24564e-17	1	0	T	6426860	T	T	6426860	3	4	118	1	0	0	0	0	1	0	0	0	13039	1319	46	4	59	4	RAC1	7	6426860	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08		6426860	152711803	16	21157											
DBNL	28988	broad.mit.edu	37	chr7	44098509	44098509	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttccctccaggagtctgcCgtgcacccgagggagatttt	6	10	12	13	2	1	1	0	0	1	1	3	4	3	2	4	2	2	2	4	2	0	3	rs148365536	byFrequency	TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr7:44098509C>T	uc003tjp.3	+	9	860	c.762C>T	c.(760-762)GCC>GCT	p.A254A	DBNL_uc003tjn.2_Silent_p.A126A|DBNL_uc003tjo.3_Silent_p.A255A|DBNL_uc003tjr.3_Silent_p.A127A|DBNL_uc003tjq.3_Silent_p.A263A|DBNL_uc011kbm.1_Silent_p.A230A|DBNL_uc011kbn.1_Silent_p.A151A|DBNL_uc011kbo.1_Silent_p.A155A|DBNL_uc011kbp.1_Silent_p.A206A|DBNL_uc011kbq.1_Silent_p.A179A|DBNL_uc011kbr.1_Silent_p.A203A|DBNL_uc011kbs.1_Silent_p.A159A	NM_001014436	NP_001014436	Q9UJU6	DBNL_HUMAN	drebrin-like isoform b	254					activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			skin(1)	1						AGGAGTCTGCCGTGCACCCGA	0.612													29	49					0	0	0	0	T	44098509	T	T	44098509	2	4	118	1	0	0	0	0	0	0	0	1	4272	639	23	1		1	DBNL	7	44098509	Silent	SNP	C	TCGA-CR-5250-01A-01D-1512-08	37671649	44098509	115040154	17	21158											
COL1A2	1278	broad.mit.edu	37	chr7	94057678	94057678	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgtgatttctctactggCgaaacctgtatccgggccca	8	12	9	12	2	1	1	0	1	1	0	3	2	2	1	3	2	3	1	3	2	4	4			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr7:94057678C>T	uc003ung.1	+	50	4071	c.3600C>T	c.(3598-3600)GGC>GGT	p.G1200G	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1200	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCTCTACTGGCGAAACCTGTA	0.428										HNSCC(75;0.22)			65	152					0	0	0	0	T	94057678	T	T	94057678	2	4	118	1	0	0	0	0	0	0	0	1	3693	755	27	1		1	COL1A2	7	94057678	Silent	SNP	C	TCGA-CR-5250-01A-01D-1512-08	49959169	94057678	65080985	18	21159											
CSMD3	114788	broad.mit.edu	37	chr8	113332168	113332168	+	Frame_Shift_Del	DEL	T	-	-																															cttccgtcaaaatttcagcaTtgggcacaggtggtggaggt																										TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr8:113332168delT	uc003ynu.2	-	46	7367	c.7208delA	c.(7207-7209)AATfs	p.N2403fs	CSMD3_uc003yns.2_Frame_Shift_Del_p.N1605fs|CSMD3_uc003ynt.2_Frame_Shift_Del_p.N2363fs|CSMD3_uc011lhx.1_Frame_Shift_Del_p.N2299fs|CSMD3_uc003ynw.1_Frame_Shift_Del_p.N114fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2403	Extracellular (Potential).|Sushi 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATTTCAGCATTGGGCACAGG	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---								-	113332168	-	-	113332168	7	5	118	1	0	1	0	1	0	0	0	0	3963	1493	52	0	4019	0	CSMD3	8	113332168	Frame_Shift_Del	DEL	T	TCGA-CR-5250-01A-01D-1512-08		113332168	33031854	19	21160											
ZFAND5	7763	broad.mit.edu	37	chr9	74975552	74975552	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaataacttacccattgggCtcattctgccactattttgc	10	14	6	11	0	2	0	1	0	1	0	2	1	2	0	2	1	4	1	2	1	4	7			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr9:74975552C>T	uc004aiv.2	-	2	421	c.143G>A	c.(142-144)AGC>AAC	p.S48N	ZFAND5_uc010mox.1_5'Flank|ZFAND5_uc010moy.1_Missense_Mutation_p.S48N|ZFAND5_uc004aix.2_Missense_Mutation_p.S48N|ZFAND5_uc004aiw.2_Missense_Mutation_p.S48N|ZFAND5_uc004aiy.2_Missense_Mutation_p.S48N	NM_006007	NP_005998	O76080	ZFAN5_HUMAN	zinc finger, AN1-type domain 5	48							DNA binding|zinc ion binding				0						ACCCATTGGGCTCATTCTGCC	0.413													117	244					0	0	0	0	T	74975552	T	T	74975552	3	4	118	1	0	0	0	0	1	0	0	0	17697	797	28	4	518	4	ZFAND5	9	74975552	Missense_Mutation	SNP	C	TCGA-CR-5250-01A-01D-1512-08		74975552	66237879	20	21161											
SH2D3C	10044	broad.mit.edu	37	chr9	130504111	130504111	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccgccgcgaagctgaacaTgttgcccatagtcccccgca	9	6	10	16	4	0	1	0	1	0	0	1	3	1	1	5	0	3	3	5	0	3	2			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr9:130504111T>C	uc004bsc.2	-	9	2186	c.2044A>G	c.(2044-2046)ATG>GTG	p.M682V	SH2D3C_uc010mxo.2_Missense_Mutation_p.M522V|SH2D3C_uc004bry.2_Missense_Mutation_p.M524V|SH2D3C_uc004brz.3_Missense_Mutation_p.M328V|SH2D3C_uc011mak.1_Missense_Mutation_p.M328V|SH2D3C_uc004bsa.2_Missense_Mutation_p.M525V|SH2D3C_uc004bsb.2_Missense_Mutation_p.M614V	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	682	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						AAGCTGAACATGTTGCCCATA	0.672													14	36					0	0	0	0	C	130504111	C	C	130504111	3	2	118	1	0	0	0	0	1	0	0	0	14299	1464	51	5	554	5	SH2D3C	9	130504111	Missense_Mutation	SNP	T	TCGA-CR-5250-01A-01D-1512-08	55528559	130504111	10709320	21	21162											
PTGES2	80142	broad.mit.edu	37	chr9	130886072	130886072	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaactcggtcacctccttgcCctgctcgttcacagccttca	6	11	7	17	2	3	0	3	0	0	0	6	1	4	0	4	1	4	2	4	1	1	3			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr9:130886072C>T	uc004bti.2	-	4	1073	c.595G>A	c.(595-597)GGC>AGC	p.G199S	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_Missense_Mutation_p.G8S|PTGES2_uc004btl.2_Missense_Mutation_p.G8S|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	199	Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0						ACCTCCTTGCCCTGCTCGTTC	0.577													24	70					0	0	0	0	T	130886072	T	T	130886072	3	4	118	1	0	0	0	0	1	0	0	0	12810	623	22	4	554	4	PTGES2	9	130886072	Missense_Mutation	SNP	C	TCGA-CR-5250-01A-01D-1512-08	381961	130886072	10327359	22	21163											
IPO7	10527	broad.mit.edu	37	chr11	9466668	9466668	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caaaatgattgagaagcatgGaggatacaaattcagtgctc	16	9	10	6	0	1	2	1	2	0	1	2	5	1	4	0	2	3	2	0	2	5	3			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr11:9466668G>C	uc001mho.2	+	25	3186	c.3044G>C	c.(3043-3045)GGA>GCA	p.G1015A		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	1015					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		GAGAAGCATGGAGGATACAAA	0.378													11	135					0	0	0	0	C	9466668	C	C	9466668	3	2	118	1	0	0	0	0	1	0	0	0	7836	1174	41	2	3142	2	IPO7	11	9466668	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08		9466668	125539848	23	21164											
CKAP5	9793	broad.mit.edu	37	chr11	46810308	46810308	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcatggcatttcagttcggtCcattagctcaacagccttga	9	12	9	11	1	2	1	2	1	0	0	4	1	3	1	2	2	3	4	2	2	2	4			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr11:46810308C>T	uc001ndi.1	-	16	2001	c.1891G>A	c.(1891-1893)GAC>AAC	p.D631N	CKAP5_uc009ylg.1_Missense_Mutation_p.D517N|CKAP5_uc001ndj.1_Missense_Mutation_p.D631N	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	631					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TCAGTTCGGTCCATTAGCTCA	0.308													41	75					0	0	0	0	T	46810308	T	T	46810308	3	4	118	1	0	0	0	0	1	0	0	0	3460	855	30	2	4323	2	CKAP5	11	46810308	Missense_Mutation	SNP	C	TCGA-CR-5250-01A-01D-1512-08	37343640	46810308	88196208	24	21165											
USP35	57558	broad.mit.edu	37	chr11	77921098	77921098	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggctgagcaggaaaaggaaGaagacagcctgggagcgggg	14	2	19	6	1	0	3	0	1	0	2	0	6	0	6	1	6	3	2	1	6	4	0			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr11:77921098G>A	uc009yva.1	+	10	2443	c.2197G>A	c.(2197-2199)GAA>AAA	p.E733K	USP35_uc001oze.2_Missense_Mutation_p.E489K|USP35_uc001ozc.2_Missense_Mutation_p.E301K|USP35_uc010rsp.1_Missense_Mutation_p.E165K|USP35_uc001ozd.2_Missense_Mutation_p.E344K|USP35_uc001ozf.2_Missense_Mutation_p.E464K	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	733					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			ggaaaaggaagaagaCAGCCT	0.333													30	60					0	0	0	0	A	77921098	A	A	77921098	3	1	118	1	0	0	0	0	1	0	0	0	17134	943	33	2	2231	2	USP35	11	77921098	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08	31110790	77921098	57085418	25	21166											
GALNT6	11226	broad.mit.edu	37	chr12	51751183	51751183	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgatgaggggcttcccccCgcggttgttctcacccacat	6	10	10	15	2	1	2	1	2	1	0	3	2	2	2	4	3	0	3	4	3	0	3	rs142431103		TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr12:51751183C>T	uc001ryk.2	-	9	1777	c.1552G>A	c.(1552-1554)GGG>AGG	p.G518R	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Missense_Mutation_p.G518R|GALNT6_uc001ryj.1_Missense_Mutation_p.G83R	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	518	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GGCTTCCCCCCGCGGTTGTTC	0.612													21	57					0	0	0	0	T	51751183	T	T	51751183	3	4	118	1	0	0	0	0	1	0	0	0	6252	652	23	1	328	1	GALNT6	12	51751183	Missense_Mutation	SNP	C	TCGA-CR-5250-01A-01D-1512-08		51751183	82100712	26	21167											
STAB2	55576	broad.mit.edu	37	chr12	104107482	104107482	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggctgactgtaagagaacCaccccaggaaggcgagtgtg	13	5	14	9	1	0	2	0	1	0	1	0	5	0	3	3	3	1	2	3	3	4	1			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr12:104107482C>A	uc001tjw.2	+	42	4659	c.4473C>A	c.(4471-4473)ACC>ACA	p.T1491T	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1491	Extracellular (Potential).|EGF-like 12.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GTAAGAGAACCACCCCAGGAA	0.542													100	273					8.45e-40	9.8883e-40	1	0	A	104107482	A	A	104107482	2	1	118	1	0	0	0	0	0	0	0	1	15304	581	21	4		4	STAB2	12	104107482	Silent	SNP	C	TCGA-CR-5250-01A-01D-1512-08	52356299	104107482	29744413	27	21168											
CIT	11113	broad.mit.edu	37	chr12	120148383	120148383	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtgcagttcatgtctagacGgtcatcaccttccagtttca	8	13	8	12	2	5	1	4	0	1	1	6	1	6	1	2	1	1	3	2	1	1	4			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr12:120148383G>T	uc001txi.1	-	37	4824	c.4771C>A	c.(4771-4773)CGT>AGT	p.R1591S	CIT_uc001txh.1_Missense_Mutation_p.R1110S|CIT_uc001txj.1_Missense_Mutation_p.R1633S	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1591	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		ATGTCTAGACGGTCATCACCT	0.483													46	118					1.23103e-26	1.38177e-26	1	0	T	120148383	T	T	120148383	3	4	118	1	0	0	0	0	1	0	0	0	3453	1116	39	3	1356	3	CIT	12	120148383	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08	16040901	120148383	13703512	28	21169											
FNDC3A	22862	broad.mit.edu	37	chr13	49772367	49772367	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgggaaaggttacaagctatAttatcaacaatttgcaacca	16	11	7	7	0	1	0	1	0	0	0	1	1	1	1	1	2	5	3	1	2	9	5			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr13:49772367A>G	uc001vcm.2	+	22	3045	c.2740A>G	c.(2740-2742)ATT>GTT	p.I914V	FNDC3A_uc001vcn.2_Missense_Mutation_p.I914V|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Missense_Mutation_p.I858V	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	914	Fibronectin type-III 7.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TACAAGCTATATTATCAACAA	0.363													58	102					0	0	0	0	G	49772367	G	G	49772367	3	3	118	1	0	0	0	0	1	0	0	0	6001	449	16	5	2833	5	FNDC3A	13	49772367	Missense_Mutation	SNP	A	TCGA-CR-5250-01A-01D-1512-08		49772367	65397511	29	21170											
DLST	1743	broad.mit.edu	37	chr14	75361079	75361079	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaggcccagaatacatgtgCaatgctgacaacttttaatg	13	10	10	8	0	0	2	0	1	0	1	0	3	0	3	1	2	4	2	1	2	5	3			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr14:75361079C>T	uc001xqv.2	+	10	800	c.737C>T	c.(736-738)GCA>GTA	p.A246V	DLST_uc001xqu.2_Missense_Mutation_p.A158V|DLST_uc001xqt.2_Missense_Mutation_p.A162V|DLST_uc010tuw.1_Missense_Mutation_p.A160V|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Missense_Mutation_p.A246V	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	246					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		AATACATGTGCAATGCTGACA	0.468													79	65					0	0	0	0	T	75361079	T	T	75361079	3	4	118	1	0	0	0	0	1	0	0	0	4591	710	25	4	775	4	DLST	14	75361079	Missense_Mutation	SNP	C	TCGA-CR-5250-01A-01D-1512-08		75361079	31988461	30	21171											
TRAF3	7187	broad.mit.edu	37	chr14	103352585	103352585	+	Frame_Shift_Del	DEL	C	-	-																															tgccctcacaagtgcagcgtCcagactctcctgaggagcga																										TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr14:103352585delC	uc001ymc.1	+	7	983	c.630delC	c.(628-630)GTCfs	p.V210fs	TRAF3_uc001yme.1_Frame_Shift_Del_p.V210fs|TRAF3_uc001ymd.1_Frame_Shift_Del_p.V210fs|TRAF3_uc010txy.1_Intron	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	210	TRAF-type 2.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		AGTGCAGCGTCCAGACTCTCC	0.498													---	---	---								-	103352585	-	-	103352585	7	5	118	1	0	1	0	1	0	0	0	0	16506	842	30	0	648	0	TRAF3	14	103352585	Frame_Shift_Del	DEL	C	TCGA-CR-5250-01A-01D-1512-08	27991506	103352585	3996955	31	21172											
APBA2	321	broad.mit.edu	37	chr15	29346705	29346705	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggccaacgggaacaccggCgcctccccctaccgcctgag	8	3	12	18	4	0	1	0	1	0	0	1	3	1	2	7	3	3	0	7	3	3	1	rs111870710	byFrequency	TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr15:29346705C>T	uc001zck.2	+	3	825	c.618C>T	c.(616-618)GGC>GGT	p.G206G	APBA2_uc010azj.2_Silent_p.G206G|APBA2_uc010uat.1_Silent_p.G206G|APBA2_uc001zcl.2_Silent_p.G206G|APBA2_uc010uas.1_Silent_p.G206G	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	206	STXBP1-binding.			DEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPY RLRR -> MSPPSLRPMTRKKMVTMCQQRGLPGLLPRGGQR EHRRLPLPPEA (in Ref. 1; AAC39767).	nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGAACACCGGCGCCTCCCCCT	0.607													17	26					0	0	0	0	T	29346705	T	T	29346705	2	4	118	1	0	0	0	0	0	0	0	1	757	755	27	1		1	APBA2	15	29346705	Silent	SNP	C	TCGA-CR-5250-01A-01D-1512-08		29346705	73184687	32	21173											
MAP2K1	5604	broad.mit.edu	37	chr15	66729094	66729099	+	In_Frame_Del	DEL	TGGAGA	-	-																															ctttctccagctaattcatcTggagatcaaacccgcaatcc																										TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr15:66729094_66729099delTGGAGA	uc010bhq.2	+	3	777_782	c.302_307delTGGAGA	c.(301-309)CTGGAGATC>CTC	p.EI102del	MAP2K1_uc010ujp.1_In_Frame_Del_p.EI80del	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	102_103	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						CTAATTCATCTGGAGATCAAACCCGC	0.447									Cardiofaciocutaneous_syndrome				---	---	---								-	66729099	-	-	66729094	7	5	118	1	0	1	0	1	0	0	0	0	9289	1580	55	0	312	0	MAP2K1	15	66729094	In_Frame_Del	DEL	TGGAGA	TCGA-CR-5250-01A-01D-1512-08	37382389	66729094	35802298	33	21174											
CLN6	54982	broad.mit.edu	37	chr15	68504043	68504043	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcttgagattcttgatgatGgggttctcacggacagacag	9	11	14	7	1	2	4	1	3	2	2	3	6	2	5	0	4	0	2	0	4	0	4			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr15:68504043G>A	uc002arf.2	-	4	614	c.456C>T	c.(454-456)CCC>CCT	p.P152P	CLN6_uc010ujy.1_Intron|CLN6_uc010ujz.1_Silent_p.P184P	NM_017882	NP_060352	Q9NWW5	CLN6_HUMAN	CLN6 protein	152					cell death|cholesterol metabolic process|ganglioside metabolic process|glycosaminoglycan metabolic process|lysosomal lumen acidification|positive regulation of proteolysis|protein catabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	protein homodimerization activity				0						TCTTGATGATGGGGTTCTCAC	0.582													61	154					0	0	0	0	A	68504043	A	A	68504043	2	1	118	1	0	0	0	0	0	0	0	1	3560	1335	47	4		4	CLN6	15	68504043	Silent	SNP	G	TCGA-CR-5250-01A-01D-1512-08	1774949	68504043	34027349	34	21175											
MYO1C	4641	broad.mit.edu	37	chr17	1374583	1374583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcacagccaccccatcctgcGgccgtcctgcccacgtgggc	5	5	11	20	3	0	0	0	0	0	0	2	0	2	0	7	2	3	1	7	2	0	0			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr17:1374583G>A	uc002fsp.2	-	20	2289	c.2069C>T	c.(2068-2070)CCG>CTG	p.P690L	MYO1C_uc002fsn.2_Missense_Mutation_p.P671L|MYO1C_uc002fso.2_Missense_Mutation_p.P655L|MYO1C_uc010vqj.1_Missense_Mutation_p.P655L|MYO1C_uc010vqk.1_Missense_Mutation_p.P666L	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	690	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCCATCCTGCGGCCGTCCTGC	0.667													22	37					0	0	0	0	A	1374583	A	A	1374583	3	1	118	1	0	0	0	0	1	0	0	0	10123	1116	39	1	1174	1	MYO1C	17	1374583	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08		1374583	79820627	35	21176											
NCR1	9437	broad.mit.edu	37	chr19	55418074	55418074	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaattctacatcccggacatGaactcccgcatggcagggca	12	7	9	13	2	1	1	0	1	1	0	3	2	3	2	2	3	2	3	2	3	3	2			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr19:55418074G>A	uc002qib.2	+	3	302	c.264G>A	c.(262-264)ATG>ATA	p.M88I	NCR1_uc002qic.2_Missense_Mutation_p.M88I|NCR1_uc002qie.2_Missense_Mutation_p.M88I|NCR1_uc002qid.2_Intron|NCR1_uc002qif.2_Intron|NCR1_uc010esj.2_Intron	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	88	Ig-like 1.|Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		TCCCGGACATGAACTCCCGCA	0.517													39	74					0	0	0	0	A	55418074	A	A	55418074	3	1	118	1	0	0	0	0	1	0	0	0	10291	1290	45	2	274	2	NCR1	19	55418074	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08		55418074	3710909	36	21177											
MC3R	4159	broad.mit.edu	37	chr20	54824431	54824431	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctgcggcgtctgtggcgtgGtgttcatcgtctactcggag	3	12	16	10	5	3	0	1	0	2	0	5	1	3	1	0	4	2	2	0	4	1	2			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr20:54824431G>C	uc002xxb.2	+	1	644	c.532G>C	c.(532-534)GTG>CTG	p.V178L		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	215	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			CTGTGGCGTGGTGTTCATCGT	0.557													55	121					0	0	0	0	C	54824431	C	C	54824431	3	2	118	1	0	0	0	0	1	0	0	0	9418	1261	44	4	534	4	MC3R	20	54824431	Missense_Mutation	SNP	G	TCGA-CR-5250-01A-01D-1512-08		54824431	8201089	37	21178											
COL6A2	1292	broad.mit.edu	37	chr21	47545929	47545929	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtggtcatcacggacgggCgccacgaccctcgggacgat	7	5	15	14	7	2	0	2	0	0	0	3	4	2	2	2	5	0	0	2	5	0	0			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr21:47545929C>T	uc002zia.1	+	26	2282	c.2200C>T	c.(2200-2202)CGC>TGC	p.R734C	COL6A2_uc002zhy.1_Missense_Mutation_p.R734C|COL6A2_uc002zhz.1_Missense_Mutation_p.R734C|COL6A2_uc002zib.1_Missense_Mutation_p.R140C|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	734	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CACGGACGGGCGCCACGACCC	0.637													47	96					0	0	0	0	T	47545929	T	T	47545929	3	4	118	1	0	0	0	0	1	0	0	0	3715	768	27	1	2298	1	COL6A2	21	47545929	Missense_Mutation	SNP	C	TCGA-CR-5250-01A-01D-1512-08		47545929	583966	38	21179											
IL3RA	3563	broad.mit.edu	37	chrX	1471026	1471026	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcaggtgcggagaatctgaCctgctggattcatgacgtgg	8	9	16	8	2	2	3	1	2	1	1	2	5	2	4	1	5	2	2	1	5	1	1			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chrX:1471026C>T	uc004cps.2	+	5	681	c.332C>T	c.(331-333)ACC>ATC	p.T111I	IL3RA_uc011mhd.1_Missense_Mutation_p.T33I	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	111	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GAGAATCTGACCTGCTGGATT	0.493													25	37					0	0	0	0	T	1471026	T	T	1471026	3	4	118	1	0	0	0	0	1	0	0	0	7734	507	18	4	346	4	IL3RA	23	1471026	Missense_Mutation	SNP	C	TCGA-CR-5250-01A-01D-1512-08		1471026	153799534	39	21180											
ZNF449	203523	broad.mit.edu	37	chrX	134494851	134494851	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tttaaatgtaattattgtggGaaaagttttagacagagacc	15	14	9	3	0	0	2	0	0	0	2	0	4	0	3	1	1	0	2	1	1	7	7			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chrX:134494851G>A	uc004eys.2	+	5	1572	c.1407G>A	c.(1405-1407)GGG>GGA	p.G469G	ZNF449_uc004eyt.2_Silent_p.G349G|ZNF449_uc004eyu.2_Silent_p.G275G	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	469	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ATTATTGTGGGAAAAGTTTTA	0.388													91	54					0	0	0	0	A	134494851	A	A	134494851	2	1	118	1	0	0	0	0	0	0	0	1	17987	1161	41	2		2	ZNF449	23	134494851	Silent	SNP	G	TCGA-CR-5250-01A-01D-1512-08	133023825	134494851	20775709	40	21181											
USP9Y	8287	broad.mit.edu	37	chrY	14885611	14885611	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atgcagtttatctttgtgatCgtgaagcctgttttaagtgg	8	17	11	5	1	1	2	0	2	1	0	2	2	1	2	1	1	2	3	1	1	3	5			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chrY:14885611C>G	uc004fst.1	+	17	3028	c.2083C>G	c.(2083-2085)CGT>GGT	p.R695G	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	695					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						TCTTTGTGATCGTGAAGCCTG	0.398													76	36					0	0	0	0	G	14885611	G	G	14885611	3	3	118	1	0	0	0	0	1	0	0	0	17159	884	31	3	2141	3	USP9Y	24	14885611	Missense_Mutation	SNP	C	TCGA-CR-5250-01A-01D-1512-08		14885611	44487955	41	21182											
KLHL17	339451	broad.mit.edu	37	chr1	898584	898584	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctccatgtccacgcgccggGcccgggtgggagtggctgcg	3	6	17	15	5	0	0	0	0	0	0	2	1	2	1	5	4	1	1	5	4	0	0			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:898584G>T	uc001aca.1	+	7	1245	c.1138G>T	c.(1138-1140)GCC>TCC	p.A380S	KLHL17_uc001acc.1_RNA|KLHL17_uc010nyb.1_Silent_p.G128G	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	380	Interaction with F-actin (By similarity).|Kelch 1.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACGCGCCGGGCCCGGGTGGG	0.716													4	13					0.00024832	0.000258525	1	0	T	898584	T	T	898584	3	4	119	1	0	0	0	0	1	0	0	0	8411	1203	42	4	1164	4	KLHL17	1	898584	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08		898584	248352037	1	21183											
WDTC1	23038	broad.mit.edu	37	chr1	27632707	27632707	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcacaggccgagtcgtggaaGatatggagggtgcttcacag	10	8	15	8	2	2	1	2	0	0	1	3	4	2	3	1	4	1	1	1	4	2	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:27632707G>A	uc009vst.2	+	16	2402	c.1867G>A	c.(1867-1869)GAT>AAT	p.D623N	WDTC1_uc001bno.2_Missense_Mutation_p.D622N|WDTC1_uc001bnp.1_RNA|WDTC1_uc001bnq.2_Missense_Mutation_p.D301N	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	623							protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		AGTCGTGGAAGATATGGAGGG	0.607													19	36					0	0	0	0	A	27632707	A	A	27632707	3	1	119	1	0	0	0	0	1	0	0	0	17410	942	33	2	1922	2	WDTC1	1	27632707	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	26734123	27632707	221617914	2	21184											
KPRP	448834	broad.mit.edu	37	chr1	152732235	152732235	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcatgcccagttcaagtttgCcaggtgtcagaccaggctcc	8	10	10	13	0	3	1	3	0	0	1	4	1	4	1	4	2	2	3	4	2	1	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:152732235C>T	uc001fal.1	+	2	229	c.171C>T	c.(169-171)TGC>TGT	p.C57C		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	57	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCAAGTTTGCCAGGTGTCAG	0.547													30	79					0	0	0	0	T	152732235	T	T	152732235	2	4	119	1	0	0	0	0	0	0	0	1	8475	747	26	4		4	KPRP	1	152732235	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08	125099528	152732235	96518386	3	21185											
LRP1B	53353	broad.mit.edu	37	chr2	141267498	141267498	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccctggccagtgttcataccGcagcctgctgtggaaagctc	7	9	11	14	1	1	0	1	0	0	0	2	1	1	1	4	2	4	4	4	2	2	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:141267498G>A	uc002tvj.1	-	52	9369	c.8397C>T	c.(8395-8397)TGC>TGT	p.C2799C		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2799	Extracellular (Potential).|LDL-receptor class A 17.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTTCATACCGCAGCCTGCTG	0.507										TSP Lung(27;0.18)			4	110					0	0	0	0	A	141267498	A	A	141267498	2	1	119	1	0	0	0	0	0	0	0	1	9005	1101	38	1		1	LRP1B	2	141267498	Silent	SNP	G	TCGA-CR-6467-01A-11D-1870-08		141267498	101931875	4	21186											
OBSL1	23363	broad.mit.edu	37	chr2	220435109	220435109	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgggagcagcgggcggccCtcccagtgccattcgatctc	5	7	13	16	4	1	0	0	0	1	0	5	2	3	1	4	3	3	1	4	3	0	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:220435109C>T	uc010fwk.2	-	1	903	c.846G>A	c.(844-846)GAG>GAA	p.E282E	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Silent_p.E282E|OBSL1_uc002vmj.2_Intron|INHA_uc002vmk.1_5'Flank	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	282	Ig-like 3.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GCGGGCGGCCCTCCCAGTGCC	0.672													10	20					0	0	0	0	T	220435109	T	T	220435109	2	4	119	1	0	0	0	0	0	0	0	1	10867	680	24	4		4	OBSL1	2	220435109	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08	79167611	220435109	22764264	5	21187											
KIF1A	547	broad.mit.edu	37	chr2	241722504	241722504	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccttgcccagggtggtcagcGacttgttgatgttggccccc	4	11	13	13	1	1	1	1	1	0	0	1	2	1	1	4	3	2	2	4	3	0	4			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:241722504G>A	uc002vzy.2	-	9	967	c.821C>T	c.(820-822)TCG>TTG	p.S274L	KIF1A_uc010fzk.2_Missense_Mutation_p.S274L|KIF1A_uc002vzz.1_Missense_Mutation_p.S274L	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	274	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GGTGGTCAGCGACTTGTTGAT	0.657													24	40					0	0	0	0	A	241722504	A	A	241722504	3	1	119	1	0	0	0	0	1	0	0	0	8322	1059	37	1	4407	1	KIF1A	2	241722504	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	21287395	241722504	1476869	6	21188											
SLC4A7	9497	broad.mit.edu	37	chr3	27431585	27431585	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcattccaaataattttataCggtcaaataactacatatag	17	13	4	7	1	1	0	1	0	0	0	2	0	2	0	1	1	3	1	1	1	9	9			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr3:27431585C>T	uc003cdv.2	-	22	3241	c.3170G>A	c.(3169-3171)CGT>CAT	p.R1057H	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.R938H|SLC4A7_uc011aww.1_Missense_Mutation_p.R1066H|SLC4A7_uc011awx.1_Missense_Mutation_p.R1053H|SLC4A7_uc011awy.1_Missense_Mutation_p.R1049H|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.R938H|SLC4A7_uc011axb.1_Missense_Mutation_p.R1053H|SLC4A7_uc010hfl.2_Missense_Mutation_p.R607H|SLC4A7_uc003cdw.2_Missense_Mutation_p.R933H	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	1057	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						TAATTTTATACGGTCAAATAA	0.328													4	163					0	0	0	0	T	27431585	T	T	27431585	3	4	119	1	0	0	0	0	1	0	0	0	14722	536	19	1	490	1	SLC4A7	3	27431585	Missense_Mutation	SNP	C	TCGA-CR-6467-01A-11D-1870-08		27431585	170590845	7	21189											
ZCCHC4	29063	broad.mit.edu	37	chr4	25314436	25314436	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacggcggcgggaagatggCggcctccaggaatgggtttg	7	6	20	8	4	0	1	0	0	0	1	1	4	1	4	2	8	0	1	2	8	2	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:25314436C>T	uc003grl.3	+	1	41	c.5C>T	c.(4-6)GCG>GTG	p.A2V		NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	2							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				GGGAAGATGGCGGCCTCCAGG	0.652											OREG0016141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	174					0	0	0	0	T	25314436	T	T	25314436	3	4	119	1	0	0	0	0	1	0	0	0	17657	768	27	1	7	1	ZCCHC4	4	25314436	Missense_Mutation	SNP	C	TCGA-CR-6467-01A-11D-1870-08		25314436	165839840	8	21190											
NAA11	84779	broad.mit.edu	37	chr4	80247011	80247011	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atattcatcaggtcgtctggCtgagcgttgcggatgttcat	7	14	12	8	3	4	1	3	1	1	0	5	2	4	2	0	3	2	3	0	3	1	4			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:80247011C>T	uc003hlt.3	-	1	161	c.21G>A	c.(19-21)CAG>CAA	p.Q7Q		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	7	Interaction with NAA15 (By similarity).|N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						GGTCGTCTGGCTGAGCGTTGC	0.522													15	25					0	0	0	0	T	80247011	T	T	80247011	2	4	119	1	0	0	0	0	0	0	0	1	10170	796	28	4		4	NAA11	4	80247011	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08	54932575	80247011	110907265	9	21191											
EGF	1950	broad.mit.edu	37	chr4	110915936	110915936	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagatgaccaccactattccGtaagaaatagtgactctgaa	16	9	7	9	1	1	5	0	3	1	2	2	5	2	5	3	0	0	1	3	0	6	4			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:110915936G>A	uc003hzy.3	+	20	3357	c.2905G>A	c.(2905-2907)GTA>ATA	p.V969I	EGF_uc011cfu.1_Missense_Mutation_p.V927I|EGF_uc011cfv.1_Missense_Mutation_p.V928I|EGF_uc010imk.2_Missense_Mutation_p.V117I	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	969	Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CCACTATTCCGTAAGAAATAG	0.443													27	47					0	0	0	0	A	110915936	A	A	110915936	3	1	119	1	0	0	0	0	1	0	0	0	4984	1145	40	1	2983	1	EGF	4	110915936	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	30668925	110915936	80238340	10	21192											
C4orf31	79625	broad.mit.edu	37	chr4	121957686	121957686	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatccacttcttttttgtaGatgcaaaacttgttcctttc	8	19	4	10	0	2	1	1	0	1	1	5	1	4	1	2	0	2	3	2	0	3	8	rs146653001		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:121957686G>A	uc003idq.1	-	4	1967	c.1440C>T	c.(1438-1440)ATC>ATT	p.I480I		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	480	Fibronectin type-III 2.										0						CTTTTTTGTAGATGCAAAACT	0.433													24	67					0	0	0	0	A	121957686	A	A	121957686	2	1	119	1	0	0	0	0	0	0	0	1	2271	932	33	2		2	C4orf31	4	121957686	Silent	SNP	G	TCGA-CR-6467-01A-11D-1870-08	11041750	121957686	69196590	11	21193											
TBC1D9	23158	broad.mit.edu	37	chr4	141583131	141583131	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgcccatttcattctgaaaAgctgggtgttctggaaggga	10	12	12	7	0	3	1	1	1	2	0	3	3	3	3	1	3	2	2	1	3	3	3			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:141583131A>T	uc010ioj.2	-	10	1991	c.1719T>A	c.(1717-1719)GCT>GCA	p.A573A		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	573	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CATTCTGAAAAGCTGGGTGTT	0.468													24	58					0	0	0	0	T	141583131	T	T	141583131	2	4	119	1	0	0	0	0	0	0	0	1	15693	59	3	5		5	TBC1D9	4	141583131	Silent	SNP	A	TCGA-CR-6467-01A-11D-1870-08	19625445	141583131	49571145	12	21194											
FAM149A	25854	broad.mit.edu	37	chr4	187074901	187074901	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agacccccgctcagtgcctgCggacacagcagcaacatcag	11	4	10	16	2	2	1	2	0	0	1	2	2	2	2	3	1	5	3	3	1	1	0			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:187074901C>T	uc003iyt.3	+	5	768	c.189C>T	c.(187-189)TGC>TGT	p.C63C	FAM149A_uc011cla.1_Silent_p.C63C|FAM149A_uc010isj.2_Silent_p.C63C|FAM149A_uc010isk.2_RNA|FAM149A_uc003iyu.3_Silent_p.C63C|FAM149A_uc010isl.2_Silent_p.C63C|FAM149A_uc011clb.1_Silent_p.C63C	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	354										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		TCAGTGCCTGCGGACACAGCA	0.468													4	174					0	0	0	0	T	187074901	T	T	187074901	2	4	119	1	0	0	0	0	0	0	0	1	5483	776	27	1		1	FAM149A	4	187074901	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08	45491770	187074901	4079375	13	21195											
GPR98	84059	broad.mit.edu	37	chr5	89943471	89943471	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcctgttgaaaaaggagaaaCgctcatttttgaggttggaa	13	12	11	5	1	1	3	1	2	0	1	2	5	2	4	1	3	1	3	1	3	4	4			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr5:89943471C>T	uc003kju.2	+	17	3275	c.3179C>T	c.(3178-3180)ACG>ATG	p.T1060M	GPR98_uc003kjt.2_Translation_Start_Site	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1060	Calx-beta 8.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAAGGAGAAACGCTCATTTTT	0.413													33	139					0	0	0	0	T	89943471	T	T	89943471	3	4	119	1	0	0	0	0	1	0	0	0	6760	536	19	1	3245	1	GPR98	5	89943471	Missense_Mutation	SNP	C	TCGA-CR-6467-01A-11D-1870-08		89943471	90971789	14	21196											
TCERG1	10915	broad.mit.edu	37	chr5	145851099	145851099	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aagaaaaggctgcccagaagGcaaagccagttgctactgct	14	6	11	10	0	0	2	0	0	0	2	0	2	0	2	2	2	5	5	2	2	6	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr5:145851099G>A	uc003lob.2	+	9	1601	c.1561G>A	c.(1561-1563)GCA>ACA	p.A521T	TCERG1_uc003loc.2_Missense_Mutation_p.A500T|TCERG1_uc011dbt.1_Missense_Mutation_p.A500T	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	521					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCCCAGAAGGCAAAGCCAGT	0.333													74	67					0	0	0	0	A	145851099	A	A	145851099	3	1	119	1	0	0	0	0	1	0	0	0	15751	1203	42	4	1595	4	TCERG1	5	145851099	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	55907628	145851099	35064161	15	21197											
HLA-A	3105	broad.mit.edu	37	chr6	29911160	29911179	+	Frame_Shift_Del	DEL	CCTGCGCTCTTGGACCGCGG	-	-																															tacatcgccctgaacgaggaCctgcgctcttggaccgcggc																								rs41552413		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:29911160_29911179delCCTGCGCTCTTGGACCGCGG	uc003nol.2	+	3	459_478	c.459_478delCCTGCGCTCTTGGACCGCGG	c.(457-480)GACCTGCGCTCTTGGACCGCGGCGfs	p.D153fs	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_RNA|HLA-A_uc010jrq.2_Frame_Shift_Del_p.D32fs|HLA-A_uc003nok.2_Frame_Shift_Del_p.D32fs|HLA-A_uc003non.2_Frame_Shift_Del_p.D153fs|HLA-A_uc003noo.2_Frame_Shift_Del_p.D153fs|HLA-A_uc010jrr.2_Frame_Shift_Del_p.D153fs|HLA-A_uc003nom.2_Frame_Shift_Del_p.D32fs|HLA-A_uc010klp.2_Frame_Shift_Del_p.D125fs|HLA-A_uc011dmc.1_Frame_Shift_Del_p.D32fs|HLA-A_uc011dmd.1_Frame_Shift_Del_p.D32fs	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	153_160	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGC	0.655									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			---	---	---								-	29911179	-	-	29911160	7	5	119	1	0	1	0	1	0	0	0	0	7234	506	18	0	469	0	HLA-A	6	29911160	Frame_Shift_Del	DEL	CCTGCGCTCTTGGACCGCGG	TCGA-CR-6467-01A-11D-1870-08		29911160	141203907	16	21198											
PPP1R10	5514	broad.mit.edu	37	chr6	30571952	30571952	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatcatggctcagacgccgCgctgtctcaaatgcatgtcg	8	11	10	12	4	3	1	3	0	1	1	5	1	3	1	1	1	1	3	1	1	2	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:30571952C>T	uc003nqn.1	-	14	1893	c.1341G>A	c.(1339-1341)GCG>GCA	p.A447A	PPP1R10_uc010jsc.1_Silent_p.A101A	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	447	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						TCAGACGCCGCGCTGTCTCAA	0.552													109	45					0	0	0	0	T	30571952	T	T	30571952	2	4	119	1	0	0	0	0	0	0	0	1	12412	755	27	1		1	PPP1R10	6	30571952	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08	660792	30571952	140543115	17	21199											
SYNE1	23345	broad.mit.edu	37	chr6	152651634	152651634	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggttcagttcatccaccGcctccccaaggcccgccacc	6	8	7	20	2	3	0	2	0	1	0	5	0	5	0	8	2	0	2	8	2	1	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:152651634G>A	uc010kiw.2	-	78	14788	c.14186C>T	c.(14185-14187)GCG>GTG	p.A4729V	SYNE1_uc003qot.3_Missense_Mutation_p.A4658V|SYNE1_uc003qou.3_Missense_Mutation_p.A4729V|SYNE1_uc010kiz.2_Missense_Mutation_p.A484V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4729	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCATCCACCGCCTCCCCAAG	0.552										HNSCC(10;0.0054)			14	42					0	0	0	0	A	152651634	A	A	152651634	3	1	119	1	0	0	0	0	1	0	0	0	15511	1087	38	1	12556	1	SYNE1	6	152651634	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	122079682	152651634	18463433	18	21200											
TTLL2	83887	broad.mit.edu	37	chr6	167754366	167754367	+	Frame_Shift_Ins	INS	-	T	T																															gtaaatggacgctcagcagaINStttttttcctaccttcgtag																								rs150247166		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:167754366_167754367insT	uc003qvs.1	+	3	1066_1067	c.978_979insT	c.(976-981)AGATTTfs	p.R326fs	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	326_327	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CGCTCAGCAGATTTTTTTCCTA	0.446													---	---	---								T	167754367	T	T	167754366	7	5	119	1	0	1	1	0	0	0	0	0	16795	330	12	0	988	0	TTLL2	6	167754366	Frame_Shift_Ins	INS	-	TCGA-CR-6467-01A-11D-1870-08	15102732	167754366	3360701	19	21201											
EIF2AK1	27102	broad.mit.edu	37	chr7	6077066	6077066	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccacttaccttcagatctcGgtgcacaattcccatgttat	9	13	5	14	1	2	1	1	0	1	1	4	1	3	1	3	1	2	2	3	1	3	4			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr7:6077066G>A	uc003spp.2	-	11	1467	c.1321C>T	c.(1321-1323)CGA>TGA	p.R441*	EIF2AK1_uc003spq.2_Nonsense_Mutation_p.R440*|EIF2AK1_uc011jwm.1_Nonsense_Mutation_p.R317*	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	441	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		TTCAGATCTCGGTGCACAATT	0.378													32	45					0	0	0	0	A	6077066	A	A	6077066	4	1	119	1	0	0	0	0	0	1	0	0	5018	1124	39	1	591	1	EIF2AK1	7	6077066	Nonsense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08		6077066	153061597	20	21202											
EEPD1	80820	broad.mit.edu	37	chr7	36194642	36194642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acctggacctgccgccagggGggcccacccagattatctcc	7	6	11	17	1	1	1	0	0	1	1	2	2	1	2	7	4	1	0	7	4	1	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr7:36194642G>A	uc003tfa.2	+	2	1349	c.709G>A	c.(709-711)GGG>AGG	p.G237R		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	237					DNA repair		DNA binding				0						GCCGCCAGGGGGGCCCACCCA	0.662													8	28					0	0	0	0	A	36194642	A	A	36194642	3	1	119	1	0	0	0	0	1	0	0	0	4954	1232	43	4	711	4	EEPD1	7	36194642	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	30117576	36194642	122944021	21	21203											
POM121L12	285877	broad.mit.edu	37	chr7	53103445	53103445	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctgctgcaaggccccgaCgccctggcggctcccatgag	5	5	12	19	3	0	1	0	1	0	0	1	2	1	1	6	3	2	3	6	3	1	0			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr7:53103445C>T	uc003tpz.2	+	1	97	c.81C>T	c.(79-81)GAC>GAT	p.D27D		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	27											0						AAGGCCCCGACGCCCTGGCGG	0.701													7	13					0	0	0	0	T	53103445	T	T	53103445	2	4	119	1	0	0	0	0	0	0	0	1	12296	535	19	1		1	POM121L12	7	53103445	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08	16908803	53103445	106035218	22	21204											
XPO7	23039	broad.mit.edu	37	chr8	21851879	21851879	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccttctactacagcgaacTctagttggcctagtaagaga	11	11	9	10	1	2	1	0	0	2	1	2	3	2	1	2	1	5	2	2	1	6	7			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:21851879T>A	uc003xaa.3	+	20	2256	c.2154T>A	c.(2152-2154)ACT>ACA	p.T718T	XPO7_uc010lti.2_Silent_p.T727T|XPO7_uc010ltk.2_Silent_p.T719T	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	718					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		TACAGCGAACTCTAGTTGGCC	0.388													18	35					0	0	0	0	A	21851879	A	A	21851879	2	1	119	1	0	0	0	0	0	0	0	1	17517	1538	54	5		5	XPO7	8	21851879	Silent	SNP	T	TCGA-CR-6467-01A-11D-1870-08		21851879	124512143	23	21205											
ASH2L	9070	broad.mit.edu	37	chr8	37986388	37986388	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tactcttctggctatggacaGggagacgtcctgggatttta	8	13	12	8	1	2	1	0	0	2	1	3	4	3	3	1	4	1	1	1	4	3	5			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:37986388G>A	uc003xkt.3	+	12	1504	c.1446G>A	c.(1444-1446)CAG>CAA	p.Q482Q	ASH2L_uc011lbk.1_Silent_p.Q343Q|ASH2L_uc003xku.3_Silent_p.Q388Q|ASH2L_uc010lwa.2_Silent_p.Q388Q	NM_004674	NP_004665	Q9UBL3	ASH2L_HUMAN	ash2-like isoform a	482	B30.2/SPRY.				hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				GCTATGGACAGGGAGACGTCC	0.443													108	487					0	0	0	0	A	37986388	A	A	37986388	2	1	119	1	0	0	0	0	0	0	0	1	1044	991	35	4		4	ASH2L	8	37986388	Silent	SNP	G	TCGA-CR-6467-01A-11D-1870-08	16134509	37986388	108377634	24	21206											
PDE7A	5150	broad.mit.edu	37	chr8	66695027	66695027	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ataatgcttacctagcatacGaatgtataatgcagtctgat	14	13	7	7	1	1	1	0	1	1	0	1	2	1	1	1	0	5	4	1	0	7	6			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:66695027G>A	uc003xvq.2	-	2	202	c.190C>T	c.(190-192)CGT>TGT	p.R64C	PDE7A_uc003xvr.2_Missense_Mutation_p.R64C|PDE7A_uc003xvp.2_Missense_Mutation_p.R38C	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	64						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	CCTAGCATACGAATGTATAAT	0.284													11	15					0	0	0	0	A	66695027	A	A	66695027	3	1	119	1	0	0	0	0	1	0	0	0	11705	1058	37	1	1338	1	PDE7A	8	66695027	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	28708639	66695027	79668995	25	21207											
ZHX2	22882	broad.mit.edu	37	chr8	123966105	123966105	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccagggtagcgacgagaaCgaggagtcgagcgttgtgga	10	5	19	7	5	0	1	0	0	0	1	1	7	0	3	1	4	3	2	1	4	2	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:123966105C>T	uc003ypk.1	+	3	2922	c.2355C>T	c.(2353-2355)AAC>AAT	p.N785N		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	785						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GCGACGAGAACGAGGAGTCGA	0.612													9	31					0	0	0	0	T	123966105	T	T	123966105	2	4	119	1	0	0	0	0	0	0	0	1	17743	535	19	1		1	ZHX2	8	123966105	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08	57271078	123966105	22397917	26	21208											
SLC24A2	25769	broad.mit.edu	37	chr9	19619581	19619581	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaaccaaagcttgatgtttaCcttcggcgagtgggtcaagg	11	10	12	8	2	1	1	1	1	0	0	2	2	1	1	2	3	3	2	2	3	4	4			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:19619581C>T	uc003zoa.1	-	3	1140	c.1078_splice	c.e3+1	p.E360_splice	SLC24A2_uc003zob.1_Splice_Site_p.G360_splice	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24						visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TTGATGTTTACCTTCGGCGAG	0.512													46	155					0	0	0	0	T	19619581	T	T	19619581	5	4	119	1	0	0	0	0	0	0	1	0	14530	521	18	4	938	4	SLC24A2	9	19619581	Splice_Site	SNP	C	TCGA-CR-6467-01A-11D-1870-08		19619581	121593850	27	21209											
C9orf23	138716	broad.mit.edu	37	chr9	34610878	34610878	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcatggaacccaggccagggGgtgctcctgggggttggtaa	7	7	18	9	0	0	0	0	0	0	0	1	1	1	1	3	7	2	4	3	7	2	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:34610878G>C	uc003zuu.2	-	2	697	c.416C>G	c.(415-417)CCC>CGC	p.P139R	C9orf23_uc003zuv.2_Missense_Mutation_p.P139R	NM_148179	NP_680545	Q8N5L8	CI023_HUMAN	hypothetical protein LOC138716	139							nucleic acid binding				0	all_epithelial(49;0.0863)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.0385)		CAGGCCAGGGGGTGCTCCTGG	0.657													26	65					0	0	0	0	C	34610878	C	C	34610878	3	2	119	1	0	0	0	0	1	0	0	0	2486	1232	43	4	79	4	C9orf23	9	34610878	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	14991297	34610878	106602553	28	21210											
MAPKAP1	79109	broad.mit.edu	37	chr9	128347842	128347842	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaatggattacttgagcttCggctcccgtccttcgcttgt	6	14	10	11	3	0	2	0	1	0	1	4	3	2	3	2	2	2	3	2	2	2	5			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:128347842C>T	uc004bpv.2	-	5	996	c.663G>A	c.(661-663)CCG>CCA	p.P221P	MAPKAP1_uc011lzt.1_Silent_p.P24P|MAPKAP1_uc010mwz.2_RNA|MAPKAP1_uc011lzu.1_Silent_p.P24P|MAPKAP1_uc011lzv.1_Silent_p.P24P|MAPKAP1_uc004bpw.2_Silent_p.P29P|MAPKAP1_uc004bpx.2_Silent_p.P29P|MAPKAP1_uc004bpy.2_Silent_p.P221P|MAPKAP1_uc004bpz.2_Silent_p.P221P|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc010mxb.1_Silent_p.P24P|MAPKAP1_uc004bqa.2_Silent_p.P221P|MAPKAP1_uc010mxc.1_Silent_p.P93P	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	221					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						ACTTGAGCTTCGGCTCCCGTC	0.532													26	111					0	0	0	0	T	128347842	T	T	128347842	2	4	119	1	0	0	0	0	0	0	0	1	9341	871	31	1		1	MAPKAP1	9	128347842	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08	93736964	128347842	12865589	29	21211											
BAT2L1	84726	broad.mit.edu	37	chr9	134367624	134367624	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtcccttcaggaggcccCgtgccatcgccacagaccta	9	7	9	16	2	1	1	1	0	0	1	3	2	2	2	6	2	1	0	6	2	2	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:134367624C>T	uc004can.3	+	29	6505	c.6450C>T	c.(6448-6450)CCC>CCT	p.P2150P	BAT2L1_uc004cao.3_Silent_p.P1507P|BAT2L1_uc004cap.3_Silent_p.P296P|BAT2L1_uc011mch.1_Silent_p.P73P	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	2150							protein binding				0						CAGGAGGCCCCGTGCCATCGC	0.552													15	88					0	0	0	0	T	134367624	T	T	134367624	2	4	119	1	0	0	0	0	0	0	0	1	1322	639	23	1		1	BAT2L1	9	134367624	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08	6019782	134367624	6845807	30	21212											
MTPAP	55149	broad.mit.edu	37	chr10	30638194	30638194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggtcaagagccccacgccgGgaaccgccattgctaaaaaa	13	4	11	13	3	1	1	1	0	0	1	1	2	1	2	5	2	3	1	5	2	5	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr10:30638194G>A	uc001iva.3	-	1	74	c.11C>T	c.(10-12)CCC>CTC	p.P4L	MTPAP_uc001ivb.3_Intron|MTPAP_uc001ivc.2_Missense_Mutation_p.P4L	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor	4					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						CCCCACGCCGGGAACCGCCAT	0.567													3	31					0	0	0	0	A	30638194	A	A	30638194	3	1	119	1	0	0	0	0	1	0	0	0	10009	1232	43	4	1773	4	MTPAP	10	30638194	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08		30638194	104896553	31	21213											
TACC2	10579	broad.mit.edu	37	chr10	123989891	123989891	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttagagtttgccatcatgcGgatagaagccctgaagctgg	10	10	13	8	1	1	3	1	1	0	2	1	4	1	4	2	2	4	3	2	2	4	3			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr10:123989891G>A	uc001lfv.2	+	16	8423	c.8063G>A	c.(8062-8064)CGG>CAG	p.R2688Q	TACC2_uc001lfw.2_Missense_Mutation_p.R834Q|TACC2_uc009xzx.2_Intron|TACC2_uc010qtv.1_Intron|TACC2_uc001lfx.2_Intron|TACC2_uc001lfy.2_Intron|TACC2_uc001lfz.2_Missense_Mutation_p.R766Q|TACC2_uc001lga.2_Intron|TACC2_uc009xzy.2_Intron|TACC2_uc001lgb.2_Intron	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2688	Potential.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCCATCATGCGGATAGAAGCC	0.567													35	93					0	0	0	0	A	123989891	A	A	123989891	3	1	119	1	0	0	0	0	1	0	0	0	15568	1116	39	1	8193	1	TACC2	10	123989891	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	93351697	123989891	11544856	32	21214											
ILK	3611	broad.mit.edu	37	chr11	6630568	6630568	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggcaatgacattgtcgtGaaggtgctgaaggttcgaga	11	9	15	6	2	0	4	0	3	0	1	2	5	0	4	0	3	1	3	0	3	3	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr11:6630568G>A	uc001mee.2	+	8	792	c.657G>A	c.(655-657)GTG>GTA	p.V219V	ILK_uc001mef.2_Silent_p.V219V|ILK_uc010rap.1_Silent_p.V85V|ILK_uc010raq.1_Silent_p.V158V|ILK_uc001meg.2_Silent_p.V65V|ILK_uc001meh.2_Silent_p.V219V|ILK_uc001mei.2_5'Flank	NM_001014794	NP_001014794	Q13418	ILK_HUMAN	integrin-linked kinase	219	Protein kinase.				cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		ACATTGTCGTGAAGGTGCTGA	0.547													24	57					0	0	0	0	A	6630568	A	A	6630568	2	1	119	1	0	0	0	0	0	0	0	1	7752	1277	45	2		2	ILK	11	6630568	Silent	SNP	G	TCGA-CR-6467-01A-11D-1870-08		6630568	128375948	33	21215											
CKAP5	9793	broad.mit.edu	37	chr11	46800015	46800015	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagactggaacctacctgatCtccgtcctcggcaaaagatc	11	8	8	14	2	1	3	0	1	1	2	5	4	2	4	4	2	2	1	4	2	4	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr11:46800015C>G	uc001ndi.1	-	21	2678	c.2568G>C	c.(2566-2568)GAG>GAC	p.E856D	CKAP5_uc009ylg.1_Missense_Mutation_p.E742D|CKAP5_uc001ndj.1_Missense_Mutation_p.E856D	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	856	HEAT 5.				cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CCTACCTGATCTCCGTCCTCG	0.413													23	54					0	0	0	0	G	46800015	G	G	46800015	3	3	119	1	0	0	0	0	1	0	0	0	3460	912	32	2	3626	2	CKAP5	11	46800015	Missense_Mutation	SNP	C	TCGA-CR-6467-01A-11D-1870-08	40169447	46800015	88206501	34	21216											
AKAP3	10566	broad.mit.edu	37	chr12	4735774	4735774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcttgttctgaactgtgtccGttaggttgtgattgctgaca	6	16	12	7	1	1	3	0	3	1	0	2	3	2	3	1	1	2	5	1	1	2	5			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr12:4735774G>A	uc001qnb.3	-	4	2523	c.2294C>T	c.(2293-2295)ACG>ATG	p.T765M		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	765					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						AACTGTGTCCGTTAGGTTGTG	0.488													30	126					0	0	0	0	A	4735774	A	A	4735774	3	1	119	1	0	0	0	0	1	0	0	0	452	1145	40	1	275	1	AKAP3	12	4735774	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08		4735774	129116121	35	21217											
KRT6B	3854	broad.mit.edu	37	chr12	52843354	52843354	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgtccaggtccaggttgcGgttgttgtccatggatagca	6	12	14	9	1	0	0	0	0	0	0	3	1	3	1	3	4	2	5	3	4	1	4			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr12:52843354G>A	uc001sak.2	-	5	1024	c.976C>T	c.(976-978)CGC>TGC	p.R326C		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	326	Rod.|Linker 12.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		TCCAGGTTGCGGTTGTTGTCC	0.527													4	220					0	0	0	0	A	52843354	A	A	52843354	3	1	119	1	0	0	0	0	1	0	0	0	8520	1116	39	1	738	1	KRT6B	12	52843354	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	48107580	52843354	81008541	36	21218											
PCDH8	5100	broad.mit.edu	37	chr13	53420242	53420242	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctttgcgcacctccttcttgCggcggttgcaggtggtggcg	2	12	15	12	4	1	0	0	0	1	0	2	0	2	0	2	5	3	3	2	5	0	4			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr13:53420242C>T	uc001vhi.2	-	1	2533	c.2330G>A	c.(2329-2331)CGC>CAC	p.R777H	PCDH8_uc001vhj.2_Missense_Mutation_p.R777H	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	777	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CTCCTTCTTGCGGCGGTTGCA	0.622													15	17					0	0	0	0	T	53420242	T	T	53420242	3	4	119	1	0	0	0	0	1	0	0	0	11571	768	27	1	894	1	PCDH8	13	53420242	Missense_Mutation	SNP	C	TCGA-CR-6467-01A-11D-1870-08		53420242	61749636	37	21219											
GPC5	2262	broad.mit.edu	37	chr13	92345950	92345950	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatactgcctcaatgtcatgCgaggctgcctggcgcacatg	8	9	12	12	2	2	0	2	0	0	0	2	2	2	0	2	2	4	2	2	2	2	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr13:92345950C>T	uc010tif.1	+	3	1201	c.835C>T	c.(835-837)CGA>TGA	p.R279*		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	279						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CAATGTCATGCGAGGCTGCCT	0.542													22	27					0	0	0	0	T	92345950	T	T	92345950	4	4	119	1	0	0	0	0	0	1	0	0	6639	760	27	1	845	1	GPC5	13	92345950	Nonsense_Mutation	SNP	C	TCGA-CR-6467-01A-11D-1870-08	38925708	92345950	22823928	38	21220											
FSCB	84075	broad.mit.edu	37	chr14	44974032	44974032	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtcagaagcaaatcagctGgtggggaatgtttgtcaacg	12	9	13	7	1	3	1	3	0	0	1	3	2	3	2	0	3	3	3	0	3	4	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr14:44974032G>A	uc001wvn.2	-	1	2468	c.2159C>T	c.(2158-2160)CCA>CTA	p.P720L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	720						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CAAATCAGCTGGTGGGGAATG	0.522													11	30					0	0	0	0	A	44974032	A	A	44974032	3	1	119	1	0	0	0	0	1	0	0	0	6100	1348	47	4	322	4	FSCB	14	44974032	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08		44974032	62375508	39	21221											
RPL4	6124	broad.mit.edu	37	chr15	66795855	66795855	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggagtacaccgatatcagtgGgcgagcacacgcctaaagaa	14	5	12	10	3	1	1	1	0	0	1	1	4	1	2	2	2	2	2	2	2	5	3	rs142487012		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr15:66795855G>A	uc002apv.2	-	2	72	c.16C>T	c.(16-18)CCA>TCA	p.P6S	RPL4_uc010bhr.2_5'UTR|RPL4_uc002apw.2_5'UTR|RPL4_uc002apx.2_5'UTR|RPL4_uc010ujq.1_Missense_Mutation_p.P6S|SNORD18C_uc010bhs.1_5'Flank|SNORD18B_uc002apy.1_5'Flank|SNORD16_uc010bht.2_5'Flank|SNORD18A_uc002apz.1_5'Flank|ZWILCH_uc010bhu.1_5'Flank|ZWILCH_uc002aqb.2_5'Flank|ZWILCH_uc002aqa.2_5'Flank|ZWILCH_uc010bhv.2_5'Flank	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	6					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						GATATCAGTGGGCGAGCACAC	0.403													26	11					0	0	0	0	A	66795855	A	A	66795855	3	1	119	1	0	0	0	0	1	0	0	0	13660	1232	43	4	1303	4	RPL4	15	66795855	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08		66795855	35735537	40	21222											
XYLT1	64131	broad.mit.edu	37	chr16	17202658	17202658	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcatgaccgggcaggctGtggggcccgtggcacagatg	6	7	17	11	2	1	2	0	1	1	1	1	2	1	2	2	5	1	4	2	5	0	0			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr16:17202658G>C	uc002dfa.2	-	12	2859	c.2774C>G	c.(2773-2775)ACA>AGA	p.T925R		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	925	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CGGGCAGGCTGTGGGGCCCGT	0.677													9	19					0	0	0	0	C	17202658	C	C	17202658	3	2	119	1	0	0	0	0	1	0	0	0	17531	1377	48	4	109	4	XYLT1	16	17202658	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08		17202658	73152095	41	21223											
GLOD4	51031	broad.mit.edu	37	chr17	685428	685428	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatccccaggacgtcccgaTagaaacgcgccgtctggaag	10	6	11	14	5	2	1	1	0	1	1	4	4	4	3	4	2	1	0	4	2	3	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:685428T>C	uc002frv.2	-	1	144	c.68A>G	c.(67-69)TAT>TGT	p.Y23C	GLOD4_uc002fru.2_Missense_Mutation_p.Y23C|GLOD4_uc010vqc.1_5'UTR|RNMTL1_uc002frw.2_5'Flank	NM_016080	NP_057164	Q9HC38	GLOD4_HUMAN	glyoxalase domain containing 4	23						mitochondrion					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		GACGTCCCGATAGAAACGCGC	0.692													13	32					0	0	0	0	C	685428	C	C	685428	3	2	119	1	0	0	0	0	1	0	0	0	6487	1406	49	5	864	5	GLOD4	17	685428	Missense_Mutation	SNP	T	TCGA-CR-6467-01A-11D-1870-08		685428	80509782	42	21224											
DNAH2	146754	broad.mit.edu	37	chr17	7668743	7668743	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggacagtctcaacggggagtGggttgtcttccaacaaactc	10	9	12	10	1	2	0	1	0	2	0	5	2	3	2	1	4	3	1	1	4	3	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:7668743G>A	uc002giu.1	+	20	3385	c.3371G>A	c.(3370-3372)TGG>TAG	p.W1124*		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1124	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AACGGGGAGTGGGTTGTCTTC	0.537													28	74					0	0	0	0	A	7668743	A	A	7668743	4	1	119	1	0	0	0	0	0	1	0	0	4624	1357	47	4	3449	4	DNAH2	17	7668743	Nonsense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	6983315	7668743	73526467	43	21225											
TBC1D3B	414059	broad.mit.edu	37	chr17	34499240	34499240	+	Frame_Shift_Del	DEL	C	-	-																															ccgtatcgatccctgaagaaCatatgcttccttaatgtccc																										TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:34499240delC	uc002hky.2	-	7	621	c.471delG	c.(469-471)ATGfs	p.M157fs	uc002hla.1_5'Flank|uc002hlc.2_5'Flank	NM_001001417	NP_001001417	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3B	157	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCCTGAAGAACATATGCTTCC	0.562													---	---	---								-	34499240	-	-	34499240	7	5	119	1	0	1	0	1	0	0	0	0	15686	478	17	0	1210	0	TBC1D3B	17	34499240	Frame_Shift_Del	DEL	C	TCGA-CR-6467-01A-11D-1870-08	26830497	34499240	46695970	44	21226											
DHX58	79132	broad.mit.edu	37	chr17	40253880	40253880	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactttttggcctggatccGcccctgaggggtctccagca	5	10	11	15	1	1	1	0	1	1	0	3	2	2	2	6	4	1	1	6	4	0	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:40253880G>A	uc002hyw.3	-	14	2159	c.1936C>T	c.(1936-1938)CGG>TGG	p.R646W	DHX58_uc002hyv.3_RNA	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	646	RNA-binding.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GCCTGGATCCGCCCCTGAGGG	0.587											OREG0024418	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	68					0	0	0	0	A	40253880	A	A	40253880	3	1	119	1	0	0	0	0	1	0	0	0	4536	1086	38	1	104	1	DHX58	17	40253880	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	5754640	40253880	40941330	45	21227											
SPOP	8405	broad.mit.edu	37	chr17	47688665	47688665	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaagatagccttgtgagccTggaattcctggccggcaaca	10	9	11	11	1	0	2	0	1	0	1	1	3	1	3	4	3	3	1	4	3	4	4			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:47688665T>C	uc010dbk.2	-	7	1267	c.635A>G	c.(634-636)CAG>CGG	p.Q212R	SPOP_uc002ipb.2_Missense_Mutation_p.Q212R|SPOP_uc002ipc.2_Missense_Mutation_p.Q212R|SPOP_uc002ipd.2_Missense_Mutation_p.Q212R|SPOP_uc002ipe.2_Missense_Mutation_p.Q212R|SPOP_uc002ipf.2_Missense_Mutation_p.Q212R|SPOP_uc002ipg.2_Missense_Mutation_p.Q212R	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein	212	BTB.				mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						CTTGTGAGCCTGGAATTCCTG	0.448										Prostate(2;0.17)			4	201					0	0	0	0	C	47688665	C	C	47688665	3	2	119	1	0	0	0	0	1	0	0	0	15150	1580	55	5	509	5	SPOP	17	47688665	Missense_Mutation	SNP	T	TCGA-CR-6467-01A-11D-1870-08	7434785	47688665	33506545	46	21228											
ITGB4	3691	broad.mit.edu	37	chr17	73753345	73753345	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgctgcaaagcgagtacagCagcatcaccaccacccacac	13	3	7	18	2	1	0	1	0	0	0	1	1	1	0	4	0	5	5	4	0	2	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:73753345C>T	uc002jpg.2	+	39	5470	c.5283C>T	c.(5281-5283)AGC>AGT	p.S1761S	ITGB4_uc002jph.2_Silent_p.S1691S|ITGB4_uc002jpi.3_Silent_p.S1691S|ITGB4_uc002jpj.2_Silent_p.S1744S|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1761	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCGAGTACAGCAGCATCACCA	0.667													16	37					0	0	0	0	T	73753345	T	T	73753345	2	4	119	1	0	0	0	0	0	0	0	1	7936	709	25	4		4	ITGB4	17	73753345	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08	26064680	73753345	7441865	47	21229											
C18orf34	374864	broad.mit.edu	37	chr18	30969508	30969508	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacattcagtcctcaccttcAgtatttgtcattttactttc	8	19	3	11	0	4	0	4	0	0	0	6	0	5	0	2	0	2	1	2	0	3	8			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr18:30969508A>C	uc002kxn.2	-	4	346	c.204T>G	c.(202-204)ACT>ACG	p.T68T	C18orf34_uc010xbr.1_Silent_p.T68T|C18orf34_uc010dmf.1_Silent_p.T68T|C18orf34_uc002kxo.2_Silent_p.T68T|C18orf34_uc002kxp.2_Silent_p.T68T	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	68										ovary(1)	1						CCTCACCTTCAGTATTTGTCA	0.279													19	43					0	0	0	0	C	30969508	C	C	30969508	2	2	119	1	0	0	0	0	0	0	0	1	1911	175	7	5		5	C18orf34	18	30969508	Silent	SNP	A	TCGA-CR-6467-01A-11D-1870-08		30969508	47107740	48	21230											
ATP5A1	498	broad.mit.edu	37	chr18	43666161	43666161	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagcatcgaggtcagaaccGaactgggcaaaagcagcaac	15	3	12	11	2	1	1	1	0	0	1	2	3	1	1	1	2	6	5	1	2	5	0	rs141613719		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr18:43666161G>A	uc002lbr.1	-	10	1437	c.1347C>T	c.(1345-1347)TTC>TTT	p.F449F	ATP5A1_uc010dnl.1_Silent_p.F399F|ATP5A1_uc002lbs.1_Silent_p.F399F|ATP5A1_uc002lbt.1_Silent_p.F449F	NM_004046	NP_004037	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	449					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism				0						GGTCAGAACCGAACTGGGCAA	0.458													51	44					0	0	0	0	A	43666161	A	A	43666161	2	1	119	1	0	0	0	0	0	0	0	1	1149	1049	37	1		1	ATP5A1	18	43666161	Silent	SNP	G	TCGA-CR-6467-01A-11D-1870-08	12696653	43666161	34411087	49	21231											
APBA3	9546	broad.mit.edu	37	chr19	3752701	3752701	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acgcccaggccctcccctcgCcgcttctcgaggtgcacctg	4	7	10	20	4	1	0	0	0	1	0	4	1	2	0	6	2	1	2	6	2	0	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr19:3752701C>G	uc002lyp.1	-	8	1377	c.1200G>C	c.(1198-1200)CGG>CGC	p.R400R	APBA3_uc002lyo.1_Silent_p.R158R	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	400	PDZ 1.				intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCCCCTCGCCGCTTCTCGA	0.746													6	8					0	0	0	0	G	3752701	G	G	3752701	2	3	119	1	0	0	0	0	0	0	0	1	758	726	26	4		4	APBA3	19	3752701	Silent	SNP	C	TCGA-CR-6467-01A-11D-1870-08		3752701	55376282	50	21232											
DPP9	91039	broad.mit.edu	37	chr19	4684712	4684712	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccttcgaaccgaagccctCgctgacaggagcccctgccg	7	5	10	19	4	0	1	0	1	0	0	2	4	0	2	7	1	4	1	7	1	2	1			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr19:4684712C>A	uc002mba.2	-	18	2399	c.2141G>T	c.(2140-2142)CGA>CTA	p.R714L		NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	685					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		CCGAAGCCCTCGCTGACAGGA	0.582													7	15					1.26484e-09	1.37326e-09	1	0	A	4684712	A	A	4684712	3	1	119	1	0	0	0	0	1	0	0	0	4755	884	31	3	557	3	DPP9	19	4684712	Missense_Mutation	SNP	C	TCGA-CR-6467-01A-11D-1870-08	932011	4684712	54444271	51	21233											
ZSCAN5B	342933	broad.mit.edu	37	chr19	56703238	56703238	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcctcctggacagtgcaGcgaccctgggcaggatctgc	6	7	13	15	1	1	0	0	0	1	0	2	3	2	2	4	3	4	2	4	3	0	0			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr19:56703238G>C	uc010ygh.1	-	2	569	c.569C>G	c.(568-570)GCT>GGT	p.A190G		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	190					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGACAGTGCAGCGACCCTGGG	0.622													6	31					0	0	0	0	C	56703238	C	C	56703238	3	2	119	1	0	0	0	0	1	0	0	0	18306	971	34	4	930	4	ZSCAN5B	19	56703238	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	52018526	56703238	2425745	52	21234											
C20orf160	140706	broad.mit.edu	37	chr20	30617557	30617557	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtttgcgatgctgctgcggGagtaccggctggggctgccc	4	9	17	11	3	0	0	0	0	0	0	0	2	0	1	2	4	6	6	2	4	1	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr20:30617557G>A	uc002wxf.2	+	8	1267	c.1254G>A	c.(1252-1254)GGG>GGA	p.G418G	C20orf160_uc002wxg.2_Missense_Mutation_p.E22K	NM_080625	NP_542192	Q9NUG4	CT160_HUMAN	hypothetical protein LOC140706	Error:Variant_position_missing_in_Q9NUG4_after_alignment										central_nervous_system(3)|ovary(1)	4						GCTGCTGCGGGAGTACCGGCT	0.617													11	54					0	0	0	0	A	30617557	A	A	30617557	2	1	119	1	0	0	0	0	0	0	0	1	2103	1161	41	2		2	C20orf160	20	30617557	Silent	SNP	G	TCGA-CR-6467-01A-11D-1870-08		30617557	32407963	53	21235											
DSN1	79980	broad.mit.edu	37	chr20	35399490	35399490	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaattctttcctctgaaacGccttgattcatctccaggga	9	14	7	11	1	4	3	1	3	3	0	6	4	5	4	3	1	1	0	3	1	2	4	rs139234953		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr20:35399490G>A	uc010gfr.2	-	3	514	c.141C>T	c.(139-141)GGC>GGT	p.G47G	DSN1_uc002xfz.2_Silent_p.G47G|DSN1_uc002xfy.3_Intron|DSN1_uc002xga.2_Silent_p.G47G|DSN1_uc010zvs.1_Intron|DSN1_uc002xgc.2_Silent_p.G31G|DSN1_uc002xgb.2_Silent_p.G31G	NM_001145316	NP_001138788	Q9H410	DSN1_HUMAN	DSN1, MIND kinetochore complex component,	47					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			ovary(2)	2		Myeloproliferative disorder(115;0.00874)				CCTCTGAAACGCCTTGATTCA	0.448													53	205					0	0	0	0	A	35399490	A	A	35399490	2	1	119	1	0	0	0	0	0	0	0	1	4802	1074	38	1		1	DSN1	20	35399490	Silent	SNP	G	TCGA-CR-6467-01A-11D-1870-08	4781933	35399490	27626030	54	21236											
MC3R	4159	broad.mit.edu	37	chr20	54823948	54823948	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcagccaacactgcctaatGgctcggagcacctccaagcc	10	7	8	16	1	1	0	1	0	0	0	3	1	2	1	5	2	5	2	5	2	3	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr20:54823948G>A	uc002xxb.2	+	1	161	c.49G>A	c.(49-51)GGC>AGC	p.G17S		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	54	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			ACTGCCTAATGGCTCGGAGCA	0.582													56	153					0	0	0	0	A	54823948	A	A	54823948	3	1	119	1	0	0	0	0	1	0	0	0	9418	1348	47	4	51	4	MC3R	20	54823948	Missense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08	19424458	54823948	8201572	55	21237											
LSS	4047	broad.mit.edu	37	chr21	47626627	47626627	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagctccagcaagtgccccCcacgcttggtctcataggtg	7	8	11	15	1	1	0	1	0	1	0	3	0	2	0	4	2	3	4	4	2	2	2			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr21:47626627C>T	uc002zij.2	-	16	1602	c.1523G>A	c.(1522-1524)GGG>GAG	p.G508E	LSS_uc011afv.1_Missense_Mutation_p.G497E|LSS_uc002zil.2_Missense_Mutation_p.G508E|LSS_uc002zik.2_Missense_Mutation_p.G428E	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	508	PFTB 2.				cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					CAAGTGCCCCCCACGCTTGGT	0.602													20	56					0	0	0	0	T	47626627	T	T	47626627	3	4	119	1	0	0	0	0	1	0	0	0	9115	623	22	4	703	4	LSS	21	47626627	Missense_Mutation	SNP	C	TCGA-CR-6467-01A-11D-1870-08		47626627	503268	56	21238											
RIMBP3	85376	broad.mit.edu	37	chr22	20458538	20458538	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctccagagcttcatcctGccccgctgggagttgactgg	5	11	11	14	1	1	2	1	1	0	1	4	3	4	3	5	2	2	3	5	2	0	3			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr22:20458538G>A	uc002zsd.3	-	1	3249	c.2764C>T	c.(2764-2766)CAG>TAG	p.Q922*		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			GCTTCATCCTGCCCCGCTGGG	0.597													10	34					0	0	0	0	A	20458538	A	A	20458538	4	1	119	1	0	0	0	0	0	1	0	0	13429	1328	46	4	2159	4	RIMBP3	22	20458538	Nonsense_Mutation	SNP	G	TCGA-CR-6467-01A-11D-1870-08		20458538	30846028	57	21239											
LAPTM5	7805	broad.mit.edu	37	chr1	31212769	31212769	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagggacaggaagggcagcaGgtacttctcccggttctgaa	10	7	14	10	1	2	1	0	1	2	0	3	3	2	3	1	5	2	4	1	5	3	3			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:31212769G>A	uc001bsc.2	-	4	365	c.274C>T	c.(274-276)CTG>TTG	p.L92L		NM_006762	NP_006753	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	92	Helical; (Potential).				transport	integral to plasma membrane|lysosomal membrane					0		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		AAGGGCAGCAGGTACTTCTCC	0.592													9	17					0	0	0	0	A	31212769	A	A	31212769	2	1	120	1	0	0	0	0	0	0	0	1	8666	991	35	4		4	LAPTM5	1	31212769	Silent	SNP	G	TCGA-CR-6470-01A-11D-1870-08		31212769	218037852	1	21240											
MACF1	23499	broad.mit.edu	37	chr1	39749133	39749133	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtaatcacttatgtgtcttcGatttatgatgccttccctaa	9	17	6	9	1	2	1	1	1	1	0	4	2	3	1	2	0	1	1	2	0	4	7	rs150686066		TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:39749133G>A	uc010ois.1	+	10	1081	c.876G>A	c.(874-876)TCG>TCA	p.S292S	MACF1_uc001cda.1_Silent_p.S200S	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	292	Actin-binding.|CH 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATGTGTCTTCGATTTATGATG	0.408													16	48					0	0	0	0	A	39749133	A	A	39749133	2	1	120	1	0	0	0	0	0	0	0	1	9195	1045	37	1		1	MACF1	1	39749133	Silent	SNP	G	TCGA-CR-6470-01A-11D-1870-08	8536364	39749133	209501488	2	21241											
IPO13	9670	broad.mit.edu	37	chr1	44433110	44433117	+	Frame_Shift_Del	DEL	TTCCCCTC	-	-																															aggccctgcagccacctggtTtcccctctgcccgcctcagc																										TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:44433110_44433117delTTCCCCTC	uc001ckx.2	+	19	3532_3539	c.2737_2744delTTCCCCTC	c.(2737-2745)TTCCCCTCTfs	p.F913fs	IPO13_uc001cky.2_Frame_Shift_Del_p.F131fs	NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	913_915					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GCCACCTGGTTTCCCCTCTGCCCGCCTC	0.615													---	---	---								-	44433117	-	-	44433110	7	5	120	1	0	1	0	1	0	0	0	0	7833	1841	64	0	2811	0	IPO13	1	44433110	Frame_Shift_Del	DEL	TTCCCCTC	TCGA-CR-6470-01A-11D-1870-08	4683977	44433110	204817511	3	21242											
CYP4A22	284541	broad.mit.edu	37	chr1	47609516	47609516	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaatgcctttcatgagaatGacaccatctacagcctgacc	12	9	8	12	0	2	3	1	3	1	1	2	5	2	4	4	1	3	0	4	1	3	2	rs143425502	byFrequency	TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:47609516G>A	uc001cqv.1	+	6	769	c.718G>A	c.(718-720)GAC>AAC	p.D240N	CYP4A22_uc009vyo.2_Missense_Mutation_p.D240N|CYP4A22_uc009vyp.2_Intron	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	240						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						TCATGAGAATGACACCATCTA	0.537													31	87					0	0	0	0	A	47609516	A	A	47609516	3	1	120	1	0	0	0	0	1	0	0	0	4201	1290	45	2	740	2	CYP4A22	1	47609516	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08	3176406	47609516	201641105	4	21243											
SLC44A5	204962	broad.mit.edu	37	chr1	75685020	75685020	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatacaggtacccccgatgtCgccaagaaactgaataaact	15	8	7	11	2	0	2	0	1	0	1	1	3	0	2	3	1	4	1	3	1	8	4			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:75685020C>T	uc001dgu.2	-	16	1332	c.1188G>A	c.(1186-1188)GCG>GCA	p.A396A	SLC44A5_uc001dgt.2_Silent_p.A396A|SLC44A5_uc001dgs.2_Silent_p.A354A|SLC44A5_uc001dgr.2_Silent_p.A354A|SLC44A5_uc010oqz.1_Silent_p.A435A|SLC44A5_uc010ora.1_Silent_p.A390A|SLC44A5_uc010orb.1_Silent_p.A266A	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	396	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						CCCCCGATGTCGCCAAGAAAC	0.393													6	33					0	0	0	0	T	75685020	T	T	75685020	2	4	120	1	0	0	0	0	0	0	0	1	14703	871	31	1		1	SLC44A5	1	75685020	Silent	SNP	C	TCGA-CR-6470-01A-11D-1870-08	28075504	75685020	173565601	5	21244											
BCAR3	8412	broad.mit.edu	37	chr1	94140372	94140372	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacatcttgataggcatctgGgcgatgctcagcgagagggg	9	8	15	9	2	3	2	1	1	2	1	3	4	3	2	0	4	2	2	0	4	1	2			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:94140372G>A	uc001dpz.2	-	2	390	c.115C>T	c.(115-117)CCA>TCA	p.P39S	BCAR3_uc001dqa.2_Missense_Mutation_p.P39S|BCAR3_uc001dqb.2_Missense_Mutation_p.P39S	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	39					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		TAGGCATCTGGGCGATGCTCA	0.537													9	49					0	0	0	0	A	94140372	A	A	94140372	3	1	120	1	0	0	0	0	1	0	0	0	1351	1232	43	4	2406	4	BCAR3	1	94140372	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08	18455352	94140372	155110249	6	21245											
FNDC7	163479	broad.mit.edu	37	chr1	109271297	109271297	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgtttcaagggatgcattCtccatgattaatgtgcactg	11	14	9	7	0	2	1	1	1	1	0	3	2	2	2	1	1	2	3	1	1	3	3			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:109271297C>T	uc001dvx.2	+	8	1413	c.1413C>T	c.(1411-1413)TTC>TTT	p.F471F	FNDC7_uc010ova.1_Silent_p.F238F	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	472	Fibronectin type-III 6.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		GGGATGCATTCTCCATGATTA	0.428													14	59					0	0	0	0	T	109271297	T	T	109271297	2	4	120	1	0	0	0	0	0	0	0	1	6005	912	32	2		2	FNDC7	1	109271297	Silent	SNP	C	TCGA-CR-6470-01A-11D-1870-08	15130925	109271297	139979324	7	21246											
C1orf107	27042	broad.mit.edu	37	chr1	210024731	210024731	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccgtggttggtgtggagcGggcggcacagatgctacagt	6	9	18	8	3	0	1	0	0	0	1	0	2	0	2	1	5	4	3	1	5	1	2	rs141651647	by1000genomes	TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:210024731G>A	uc001hhr.1	+	12	2286	c.2210G>A	c.(2209-2211)CGG>CAG	p.R737Q	C1orf107_uc009xcu.1_Missense_Mutation_p.R452Q	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	737					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		GGTGTGGAGCGGGCGGCACAG	0.498													11	38					0	0	0	0	A	210024731	A	A	210024731	3	1	120	1	0	0	0	0	1	0	0	0	1990	1116	39	1	2256	1	C1orf107	1	210024731	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08	100753434	210024731	39225890	8	21247											
NID1	4811	broad.mit.edu	37	chr1	236195924	236195924	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacaaagatccttcctttCaccttgccattgactcgctg	8	12	5	16	1	1	2	1	1	0	1	4	2	3	2	5	0	1	1	5	0	1	4			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:236195924C>A	uc001hxo.2	-	6	1416	c.1314G>T	c.(1312-1314)GTG>GTT	p.V438V	NID1_uc009xgd.2_Silent_p.V438V	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	438	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TCCTTCCTTTCACCTTGCCAT	0.478													9	40					1.12685e-05	1.22235e-05	1	0	A	236195924	A	A	236195924	2	1	120	1	0	0	0	0	0	0	0	1	10468	813	29	2		2	NID1	1	236195924	Silent	SNP	C	TCGA-CR-6470-01A-11D-1870-08	26171193	236195924	13054697	9	21248											
HEATR1	55127	broad.mit.edu	37	chr1	236766584	236766584	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctttggtctgaacacttcGctccaaggtttttgctagct	6	16	9	10	1	1	1	0	1	1	0	3	1	2	1	1	2	4	5	1	2	3	5			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:236766584G>A	uc001hyd.1	-	3	360	c.235C>T	c.(235-237)CGA>TGA	p.R79*	HEATR1_uc001hye.1_Nonsense_Mutation_p.R79*	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	79					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TGAACACTTCGCTCCAAGGTT	0.418													11	64					0	0	0	0	A	236766584	A	A	236766584	4	1	120	1	0	0	0	0	0	1	0	0	7066	1095	38	1	6371	1	HEATR1	1	236766584	Nonsense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08	570660	236766584	12484037	10	21249											
NCAPH	23397	broad.mit.edu	37	chr2	97019076	97019076	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtgcagaagatcgccagAtctgcccttccctggccggg	7	8	13	13	2	1	3	0	0	1	3	3	3	2	3	4	2	2	1	4	2	1	1			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr2:97019076A>T	uc002svz.1	+	8	1027	c.943A>T	c.(943-945)ATC>TTC	p.I315F	NCAPH_uc010fhu.1_Missense_Mutation_p.I291F|NCAPH_uc010fhv.1_Missense_Mutation_p.I304F|NCAPH_uc010yum.1_Missense_Mutation_p.I291F|NCAPH_uc010fhw.1_Missense_Mutation_p.I304F|NCAPH_uc010yun.1_Missense_Mutation_p.I179F|NCAPH_uc002swa.1_5'UTR	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	315					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				AGATCGCCAGATCTGCCCTTC	0.502													16	36					0	0	0	0	T	97019076	T	T	97019076	3	4	120	1	0	0	0	0	1	0	0	0	10263	333	12	5	973	5	NCAPH	2	97019076	Missense_Mutation	SNP	A	TCGA-CR-6470-01A-11D-1870-08		97019076	146180297	11	21250											
SCN3A	6328	broad.mit.edu	37	chr2	165997340	165997340	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcgctctccatgtctgtgcgGcacaaacagtgagtctctcc	7	11	9	14	2	3	1	0	1	3	0	7	1	4	1	2	1	2	2	2	1	1	0			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr2:165997340G>A	uc002ucx.2	-	13	2332	c.1840C>T	c.(1840-1842)CCG>TCG	p.P614S	SCN3A_uc002ucy.2_Missense_Mutation_p.P614S|SCN3A_uc002ucz.2_Missense_Mutation_p.P614S|SCN3A_uc002uda.1_Missense_Mutation_p.P483S|SCN3A_uc002udb.1_Missense_Mutation_p.P483S	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	614						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TGTCTGTGCGGCACAAACAGT	0.507													4	59					0	0	0	0	A	165997340	A	A	165997340	3	1	120	1	0	0	0	0	1	0	0	0	13983	1203	42	4	4226	4	SCN3A	2	165997340	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08	68978264	165997340	77202033	12	21251											
SCN7A	6332	broad.mit.edu	37	chr2	167273486	167273486	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttgttttgatcaaagctcTcacaaccacctggtatatat	11	14	7	9	0	2	1	2	1	1	0	3	1	2	1	2	2	2	4	2	2	5	6			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr2:167273486T>C	uc002udu.1	-	20	3272	c.3145A>G	c.(3145-3147)AGA>GGA	p.R1049G	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1049					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						ATCAAAGCTCTCACAACCACC	0.323													4	15					0	0	0	0	C	167273486	C	C	167273486	3	2	120	1	0	0	0	0	1	0	0	0	13988	1559	54	5	1927	5	SCN7A	2	167273486	Missense_Mutation	SNP	T	TCGA-CR-6470-01A-11D-1870-08	1276146	167273486	75925887	13	21252											
TTN	7273	broad.mit.edu	37	chr2	179597035	179597035	+	Frame_Shift_Del	DEL	A	-	-																															tggcatctcccttctttaacAgctgtgatggctctaacttt																										TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr2:179597035delA	uc010zfg.1	-	54	13153	c.12929delT	c.(12928-12930)CTGfs	p.L4310fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.L971fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5237							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTTTAACAGCTGTGATGG	0.393													---	---	---								-	179597035	-	-	179597035	7	5	120	1	0	1	0	1	0	0	0	0	16803	188	7	0	88092	0	TTN	2	179597035	Frame_Shift_Del	DEL	A	TCGA-CR-6470-01A-11D-1870-08	12323549	179597035	63602338	14	21253											
TTN	7273	broad.mit.edu	37	chr2	179598097	179598097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cattgtttttaaaacttattCggtattttttactggcgacc	9	19	6	7	2	0	0	0	0	0	0	1	1	0	0	1	2	2	2	1	2	5	10	rs146847928	by1000genomes	TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr2:179598097C>T	uc010zfg.1	-	51	12415	c.12191G>A	c.(12190-12192)CGA>CAA	p.R4064Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R725Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4991							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAACTTATTCGGTATTTTTT	0.473													28	89					0	0	0	0	T	179598097	T	T	179598097	3	4	120	1	0	0	0	0	1	0	0	0	16803	884	31	1	88842	1	TTN	2	179598097	Missense_Mutation	SNP	C	TCGA-CR-6470-01A-11D-1870-08	1062	179598097	63601276	15	21254											
PFN2	5217	broad.mit.edu	37	chr3	149684321	149684321	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgccattgagtatgccttCttattcaatccgcctccatg	7	16	6	12	1	2	1	1	1	1	0	4	1	4	1	5	0	2	1	5	0	3	6			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr3:149684321C>T	uc003ext.1	-	3	476	c.378G>A	c.(376-378)AAG>AAA	p.K126K	PFN2_uc003exs.1_Intron|PFN2_uc003exu.1_Intron|PFN2_uc011bnu.1_Intron	NM_053024	NP_444252	P35080	PROF2_HUMAN	profilin 2 isoform a	126					actin cytoskeleton organization|regulation of actin polymerization or depolymerization	actin cytoskeleton|cytoplasm	actin binding|phosphatidylinositol-4,5-bisphosphate binding				0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AGTATGCCTTCTTATTCAATC	0.393													13	729					0	0	0	0	T	149684321	T	T	149684321	2	4	120	1	0	0	0	0	0	0	0	1	11823	912	32	2		2	PFN2	3	149684321	Silent	SNP	C	TCGA-CR-6470-01A-11D-1870-08		149684321	48338109	16	21255											
ECT2	1894	broad.mit.edu	37	chr3	172501696	172501696	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaagatttcatgcttttctCaaggtaatgtgtgtttcttt	8	19	7	7	0	3	1	2	0	2	1	4	1	3	1	1	1	1	3	1	1	3	6			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr3:172501696C>T	uc003fii.2	+	15	1770	c.1632C>T	c.(1630-1632)CTC>CTT	p.L544L	ECT2_uc010hwv.1_Silent_p.L575L|ECT2_uc003fih.2_Silent_p.L543L|ECT2_uc003fij.1_Silent_p.L544L|ECT2_uc003fik.1_Silent_p.L544L|ECT2_uc003fil.1_Silent_p.L575L	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	544	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			ATGCTTTTCTCAAGGTAATGT	0.269													12	156					0	0	0	0	T	172501696	T	T	172501696	2	4	120	1	0	0	0	0	0	0	0	1	4923	813	29	2		2	ECT2	3	172501696	Silent	SNP	C	TCGA-CR-6470-01A-11D-1870-08	22817375	172501696	25520734	17	21256											
SULT1B1	27284	broad.mit.edu	37	chr4	70615521	70615521	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggggtgatggattcttcTccaattgttctatacctgag	7	15	10	9	1	3	2	0	2	3	0	5	3	4	3	3	3	1	1	3	3	3	6			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr4:70615521T>C	uc003hen.2	-	4	591	c.293A>G	c.(292-294)GAG>GGG	p.E98G		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	98					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						TGGATTCTTCTCCAATTGTTC	0.383													17	72					0	0	0	0	C	70615521	C	C	70615521	3	2	120	1	0	0	0	0	1	0	0	0	15442	1551	54	5	617	5	SULT1B1	4	70615521	Missense_Mutation	SNP	T	TCGA-CR-6470-01A-11D-1870-08		70615521	120538755	18	21257											
HIST1H4D	8360	broad.mit.edu	37	chr6	26189157	26189157	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgagtttcctcataaatgaGgccagaaatacgcttgacgc	12	9	10	10	3	1	3	1	2	0	1	2	4	2	3	2	1	1	2	2	1	4	4			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr6:26189157G>A	uc003ngu.2	-	1	148	c.148C>T	c.(148-150)CTC>TTC	p.L50F		NM_003539	NP_003530	P62805	H4_HUMAN	histone cluster 1, H4d	50					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				TCATAAATGAGGCCAGAAATA	0.542													23	60					0	0	0	0	A	26189157	A	A	26189157	3	1	120	1	0	0	0	0	1	0	0	0	7207	1000	35	4	167	4	HIST1H4D	6	26189157	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08		26189157	144925910	19	21258											
TRDN	10345	broad.mit.edu	37	chr6	123869615	123869615	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacctttatcagtatcttcGtcaccatcatcatcttcttc	8	17	3	13	1	7	0	4	0	3	0	9	0	7	0	2	0	1	2	2	0	3	7			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr6:123869615G>A	uc003pzj.1	-	3	397	c.375C>T	c.(373-375)GAC>GAT	p.D125D	TRDN_uc003pzk.1_Silent_p.D125D|TRDN_uc003pzl.1_Silent_p.D125D|TRDN_uc010ken.2_Silent_p.D125D|TRDN_uc010keo.1_Silent_p.D125D	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	125	Lumenal.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		CAGTATCTTCGTCACCATCAT	0.363													4	13					0	0	0	0	A	123869615	A	A	123869615	2	1	120	1	0	0	0	0	0	0	0	1	16535	1136	40	1		1	TRDN	6	123869615	Silent	SNP	G	TCGA-CR-6470-01A-11D-1870-08	97680458	123869615	47245452	20	21259											
LFNG	3955	broad.mit.edu	37	chr7	2565945	2565945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcaccatcggctacatcGtggaggccctgctgggtgtg	6	9	14	12	2	0	0	0	0	0	0	2	1	0	1	2	4	3	3	2	4	1	1			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr7:2565945G>A	uc003smf.2	+	6	906	c.889G>A	c.(889-891)GTG>ATG	p.V297M	LFNG_uc003smg.2_Missense_Mutation_p.V297M	NM_001040167	NP_001035257	Q8NES3	LFNG_HUMAN	lunatic fringe isoform a	297	Lumenal (Potential).				organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		CGGCTACATCGTGGAGGCCCT	0.657													20	65					0	0	0	0	A	2565945	A	A	2565945	3	1	120	1	0	0	0	0	1	0	0	0	8777	1145	40	1	1187	1	LFNG	7	2565945	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08		2565945	156572718	21	21260											
ADCY1	107	broad.mit.edu	37	chr7	45743232	45743232	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcctactcccaggtgggcGtcatgtttgcctccatcccc	5	11	9	16	1	1	0	1	0	0	0	5	0	5	0	6	2	2	1	6	2	1	2			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr7:45743232G>A	uc003tne.3	+	16	2623	c.2605G>A	c.(2605-2607)GTC>ATC	p.V869I		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	869	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCAGGTGGGCGTCATGTTTGC	0.572													17	66					0	0	0	0	A	45743232	A	A	45743232	3	1	120	1	0	0	0	0	1	0	0	0	292	1145	40	1	2667	1	ADCY1	7	45743232	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08	43177287	45743232	113395431	22	21261											
CYP51A1	1595	broad.mit.edu	37	chr7	91758200	91758200	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagtgtcacctactggattAggcacatcgtatgcaactcc	11	10	8	12	1	1	0	1	0	0	0	3	1	2	1	2	2	3	3	2	2	4	3			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr7:91758200A>G	uc003ulm.3	-	3	624	c.462T>C	c.(460-462)CCT>CCC	p.P154P	CYP51A1_uc011khn.1_Silent_p.P49P|CYP51A1_uc003uln.3_Silent_p.P91P	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	148					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	CTACTGGATTAGGCACATCGT	0.363													3	184					0	0	0	0	G	91758200	G	G	91758200	2	3	120	1	0	0	0	0	0	0	0	1	4212	407	15	5		5	CYP51A1	7	91758200	Silent	SNP	A	TCGA-CR-6470-01A-11D-1870-08	46014968	91758200	67380463	23	21262											
MLL5	55904	broad.mit.edu	37	chr7	104752281	104752281	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctcttcatagcctggttcaCctggatctgtaattcctgct	6	16	7	12	0	4	0	2	0	2	0	6	1	5	1	3	2	2	3	3	2	2	5			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr7:104752281C>T	uc003vcm.2	+	27	4612	c.4078C>T	c.(4078-4080)CCT>TCT	p.P1360S	MLL5_uc010ljc.2_Missense_Mutation_p.P1360S|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.P94S	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1360					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCCTGGTTCACCTGGATCTGT	0.378													13	40					0	0	0	0	T	104752281	T	T	104752281	3	4	120	1	0	0	0	0	1	0	0	0	9677	507	18	4	4176	4	MLL5	7	104752281	Missense_Mutation	SNP	C	TCGA-CR-6470-01A-11D-1870-08	12994081	104752281	54386382	24	21263											
EXOC4	60412	broad.mit.edu	37	chr7	133689777	133689777	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtcaagctcaacaaagatAtcagcgccattgaagaggcc	14	7	10	10	1	3	3	3	1	0	2	3	3	3	3	2	2	3	1	2	2	5	2			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr7:133689777A>G	uc003vrk.2	+	16	2496	c.2461A>G	c.(2461-2463)ATC>GTC	p.I821V	EXOC4_uc011kpo.1_Missense_Mutation_p.I720V|EXOC4_uc003vrl.2_Missense_Mutation_p.I431V|EXOC4_uc011kpp.1_Missense_Mutation_p.I353V|EXOC4_uc011kpq.1_Missense_Mutation_p.I109V	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	821					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				CAACAAAGATATCAGCGCCAT	0.498													3	133					0	0	0	0	G	133689777	G	G	133689777	3	3	120	1	0	0	0	0	1	0	0	0	5330	449	16	5	2532	5	EXOC4	7	133689777	Missense_Mutation	SNP	A	TCGA-CR-6470-01A-11D-1870-08	28937496	133689777	25448886	25	21264											
SVIL	6840	broad.mit.edu	37	chr10	29801693	29801693	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagggaccgccctgcttcctGggtgtgcaggctgctggccg	3	8	17	13	2	0	0	0	0	0	0	1	2	1	1	4	4	3	4	4	4	0	1			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr10:29801693G>A	uc001iut.1	-	17	4240	c.3487C>T	c.(3487-3489)CAG>TAG	p.Q1163*	SVIL_uc010qdw.1_Nonsense_Mutation_p.Q61*|SVIL_uc001iuu.1_Nonsense_Mutation_p.Q737*	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1163					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CCTGCTTCCTGGGTGTGCAGG	0.542											OREG0020097	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	67					0	0	0	0	A	29801693	A	A	29801693	4	1	120	1	0	0	0	0	0	1	0	0	15487	1357	47	4	3245	4	SVIL	10	29801693	Nonsense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08		29801693	105733054	26	21265											
NRP1	8829	broad.mit.edu	37	chr10	33474639	33474639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtttccttttccgatttcgCcctcgaaaatcacctaacaa	10	13	5	13	3	1	0	1	0	0	0	5	2	3	0	4	1	1	1	4	1	4	5			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr10:33474639C>T	uc001iwx.3	-	15	2871	c.2348G>A	c.(2347-2349)GGC>GAC	p.G783D	NRP1_uc001iwv.3_Missense_Mutation_p.G783D|NRP1_uc009xlz.2_Missense_Mutation_p.G777D|NRP1_uc001iww.3_Missense_Mutation_p.G595D|NRP1_uc001iwy.3_Missense_Mutation_p.G776D	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	783	Extracellular (Potential).|MAM.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	TCCGATTTCGCCCTCGAAAAT	0.403													3	43					0	0	0	0	T	33474639	T	T	33474639	3	4	120	1	0	0	0	0	1	0	0	0	10714	739	26	4	435	4	NRP1	10	33474639	Missense_Mutation	SNP	C	TCGA-CR-6470-01A-11D-1870-08	3672946	33474639	102060108	27	21266											
FAM53B	9679	broad.mit.edu	37	chr10	126312097	126312097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctggtgttgctgacgtggCgggcgaaggggctctgggga	4	8	20	9	3	1	1	0	1	1	0	1	3	1	2	1	7	1	3	1	7	1	1			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr10:126312097C>T	uc001lhv.1	-	5	1506	c.983G>A	c.(982-984)CGC>CAC	p.R328H	FAM53B_uc001lhu.1_Intron	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	328										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		GCTGACGTGGCGGGCGAAGGG	0.697													7	5					0	0	0	0	T	126312097	T	T	126312097	3	4	120	1	0	0	0	0	1	0	0	0	5612	768	27	1	289	1	FAM53B	10	126312097	Missense_Mutation	SNP	C	TCGA-CR-6470-01A-11D-1870-08	92837458	126312097	9222650	28	21267											
SLC25A22	79751	broad.mit.edu	37	chr11	792587	792587	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgagtcccttgtagagacCggcaatgccacggctccgca	8	6	11	16	4	0	1	0	0	0	1	2	3	2	1	5	2	1	4	5	2	2	2			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr11:792587C>T	uc001lri.2	-	7	895	c.553G>A	c.(553-555)GGT>AGT	p.G185S	CEND1_uc001lrh.1_5'Flank|SLC25A22_uc009yci.2_Missense_Mutation_p.G185S|SLC25A22_uc001lrj.2_Missense_Mutation_p.G185S	NM_024698	NP_078974	Q9H936	GHC1_HUMAN	mitochondrial glutamate carrier 1	185	Solcar 2.					integral to membrane|mitochondrial inner membrane|nucleus	L-glutamate transmembrane transporter activity|protein binding|symporter activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	L-Glutamic Acid(DB00142)	TTGTAGAGACCGGCAATGCCA	0.736													7	18					0	0	0	0	T	792587	T	T	792587	3	4	120	1	0	0	0	0	1	0	0	0	14549	652	23	1	434	1	SLC25A22	11	792587	Missense_Mutation	SNP	C	TCGA-CR-6470-01A-11D-1870-08		792587	134213929	29	21268											
PTPRJ	5795	broad.mit.edu	37	chr11	48145371	48145371	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaacatcaacccgtatcttCtacaatcaaataagacaaag	19	8	3	11	1	4	1	2	0	2	1	4	1	4	1	1	0	3	1	1	0	8	4			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr11:48145371C>G	uc001ngp.3	+	5	1178	c.823C>G	c.(823-825)CTA>GTA	p.L275V	PTPRJ_uc001ngo.3_Missense_Mutation_p.L275V	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	275	Extracellular (Potential).|Fibronectin type-III 2.|Fibronectin type-III 3.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						CCCGTATCTTCTACAATCAAA	0.473													24	63					0	0	0	0	G	48145371	G	G	48145371	3	3	120	1	0	0	0	0	1	0	0	0	12869	912	32	2	841	2	PTPRJ	11	48145371	Missense_Mutation	SNP	C	TCGA-CR-6470-01A-11D-1870-08	47352784	48145371	86861145	30	21269											
SPTBN2	6712	broad.mit.edu	37	chr11	66457726	66457726	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgtaggccttctggagcCggtggccgtcgtcctgcacc	4	8	14	15	4	1	0	0	0	1	0	3	1	2	1	5	4	3	2	5	4	1	2			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr11:66457726C>T	uc001ojd.2	-	27	5666	c.5594G>A	c.(5593-5595)CGG>CAG	p.R1865Q	SPTBN2_uc001ojc.1_5'Flank	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1865	Spectrin 15.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CTTCTGGAGCCGGTGGCCGTC	0.701													5	10					0	0	0	0	T	66457726	T	T	66457726	3	4	120	1	0	0	0	0	1	0	0	0	15186	652	23	1	1622	1	SPTBN2	11	66457726	Missense_Mutation	SNP	C	TCGA-CR-6470-01A-11D-1870-08	18312355	66457726	68548790	31	21270											
ERC1	23085	broad.mit.edu	37	chr12	1553834	1553834	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agaccccctgatcctccgtgGactcactccaccagcttcct	7	9	6	19	1	1	2	1	1	0	1	5	3	5	3	7	1	1	1	7	1	0	1			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr12:1553834G>A	uc001qjb.2	+	18	3372	c.3131G>A	c.(3130-3132)GGA>GAA	p.G1044E	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.G1016E|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Missense_Mutation_p.G1044E|ERC1_uc010sdv.1_3'UTR|ERC1_uc001qje.2_RNA	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	1044					I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			ATCCTCCGTGGACTCACTCCA	0.522													29	95					0	0	0	0	A	1553834	A	A	1553834	3	1	120	1	0	0	0	0	1	0	0	0	5234	1174	41	2	3197	2	ERC1	12	1553834	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08		1553834	132298061	32	21271											
CTDSP2	10106	broad.mit.edu	37	chr12	58217826	58217826	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actcacggaataggcgggccCggaacaccccacaccggtcc	10	3	11	17	4	1	0	1	0	0	0	2	2	2	2	5	5	1	0	5	5	3	1			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr12:58217826C>T	uc001sqm.2	-	7	1080	c.551G>A	c.(550-552)CGG>CAG	p.R184Q	CTDSP2_uc010ssg.1_Missense_Mutation_p.R58Q|CTDSP2_uc009zqf.2_Missense_Mutation_p.R32Q|CTDSP2_uc009zqg.2_Intron	NM_005730	NP_005721	O14595	CTDS2_HUMAN	nuclear LIM interactor-interacting factor 2	184	FCP1 homology.				protein dephosphorylation	nucleus|soluble fraction	CTD phosphatase activity|metal ion binding			central_nervous_system(1)	1	all_neural(12;0.00559)|Glioma(12;0.0143)|Melanoma(17;0.122)					TAGGCGGGCCCGGAACACCCC	0.587													4	28					0	0	0	0	T	58217826	T	T	58217826	3	4	120	1	0	0	0	0	1	0	0	0	4021	652	23	1	272	1	CTDSP2	12	58217826	Missense_Mutation	SNP	C	TCGA-CR-6470-01A-11D-1870-08	56663992	58217826	75634069	33	21272											
CATSPERB	79820	broad.mit.edu	37	chr14	92136312	92136312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggcaatggcagttttcCtgacctaggtaaacaaagaa	15	8	10	8	0	0	3	0	1	0	2	1	3	1	3	2	3	1	4	2	3	6	4			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr14:92136312C>T	uc001xzs.1	-	14	1273	c.1133G>A	c.(1132-1134)AGG>AAG	p.R378K	CATSPERB_uc010aub.1_5'UTR	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	378					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				GGCAGTTTTCCTGACCTAGGT	0.358													21	42					0	0	0	0	T	92136312	T	T	92136312	3	4	120	1	0	0	0	0	1	0	0	0	2703	681	24	4	2273	4	CATSPERB	14	92136312	Missense_Mutation	SNP	C	TCGA-CR-6470-01A-11D-1870-08		92136312	15213228	34	21273											
CYLD	1540	broad.mit.edu	37	chr16	50818266	50818266	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttttagttctgttctggAcactgtgttacttagaccca	7	17	8	9	0	2	1	0	0	2	1	2	2	2	2	1	1	2	4	1	1	3	6			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr16:50818266A>C	uc002egp.1	+	12	2268	c.1853A>C	c.(1852-1854)GAC>GCC	p.D618A	CYLD_uc002ego.2_Missense_Mutation_p.D615A|CYLD_uc010cbs.1_Missense_Mutation_p.D615A|CYLD_uc002egq.1_Missense_Mutation_p.D615A|CYLD_uc002egr.1_Missense_Mutation_p.D615A|CYLD_uc002egs.1_Missense_Mutation_p.D615A	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	618					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TCTGTTCTGGACACTGTGTTA	0.318			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				18	56					0	0	0	0	C	50818266	C	C	50818266	3	2	120	1	0	0	0	0	1	0	0	0	4160	275	10	5	1891	5	CYLD	16	50818266	Missense_Mutation	SNP	A	TCGA-CR-6470-01A-11D-1870-08		50818266	39536487	35	21274											
CCDC113	29070	broad.mit.edu	37	chr16	58287951	58287951	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacaggtatggaccgtggggTaggcctgactgccgaccaaa	10	6	15	10	2	0	1	0	1	0	0	0	4	0	2	4	5	1	2	4	5	3	2			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr16:58287951T>C	uc002ene.2	+	3	357	c.278T>C	c.(277-279)GTA>GCA	p.V93A	CCDC113_uc010vid.1_Intron	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	93						protein complex					0						GACCGTGGGGTAGGCCTGACT	0.507													6	75					0	0	0	0	C	58287951	C	C	58287951	3	2	120	1	0	0	0	0	1	0	0	0	2762	1638	57	5	288	5	CCDC113	16	58287951	Missense_Mutation	SNP	T	TCGA-CR-6470-01A-11D-1870-08	7469685	58287951	32066802	36	21275											
RASL10B	91608	broad.mit.edu	37	chr17	34067531	34067531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagtacgtcaagaccatccGccagcagatcctggagacga	12	6	11	12	3	1	4	1	1	0	3	3	6	3	4	4	1	2	2	4	1	2	1			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr17:34067531G>A	uc002hju.2	+	3	686	c.320G>A	c.(319-321)CGC>CAC	p.R107H		NM_033315	NP_201572	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B precursor	107	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			lung(2)|breast(2)	4				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AAGACCATCCGCCAGCAGATC	0.577													21	43					0	0	0	0	A	34067531	A	A	34067531	3	1	120	1	0	0	0	0	1	0	0	0	13145	1087	38	1	326	1	RASL10B	17	34067531	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08		34067531	47127679	37	21276											
ABCA8	10351	broad.mit.edu	37	chr17	66898960	66898960	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggtgtaactgttttgataTattttcaccatggtatactc	10	17	7	7	0	1	1	1	1	0	0	2	1	1	1	1	2	2	3	1	2	5	9			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr17:66898960T>C	uc002jhp.2	-	19	2717	c.2538A>G	c.(2536-2538)ATA>ATG	p.I846M	ABCA8_uc002jhq.2_Missense_Mutation_p.I886M|ABCA8_uc010wqq.1_Missense_Mutation_p.I886M|ABCA8_uc010wqr.1_Missense_Mutation_p.I825M|ABCA8_uc002jhr.2_Missense_Mutation_p.I886M	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	846						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TGTTTTGATATATTTTCACCA	0.378													15	62					0	0	0	0	C	66898960	C	C	66898960	3	2	120	1	0	0	0	0	1	0	0	0	38	1396	49	5	2287	5	ABCA8	17	66898960	Missense_Mutation	SNP	T	TCGA-CR-6470-01A-11D-1870-08	32831429	66898960	14296250	38	21277											
ZCCHC2	54877	broad.mit.edu	37	chr18	60241452	60241452	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcccttaaactcacccaagtAtcagcatatttcttttatgc	11	15	3	12	0	3	0	2	0	1	0	4	0	4	0	2	0	3	2	2	0	6	6			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr18:60241452A>C	uc002lip.3	+	13	2138	c.2138A>C	c.(2137-2139)TAT>TCT	p.Y713S	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Missense_Mutation_p.Y183S	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	713					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						TCACCCAAGTATCAGCATATT	0.443													46	178					0	0	0	0	C	60241452	C	C	60241452	3	2	120	1	0	0	0	0	1	0	0	0	17654	449	16	5	2188	5	ZCCHC2	18	60241452	Missense_Mutation	SNP	A	TCGA-CR-6470-01A-11D-1870-08		60241452	17835796	39	21278											
DAPK3	1613	broad.mit.edu	37	chr19	3964913	3964913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccggctggatgacaggcggcGcttcttgatgaacttggctg	6	10	15	10	3	1	3	0	3	1	0	1	4	1	4	1	5	1	3	1	5	1	3			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr19:3964913G>A	uc002lzc.1	-	2	232	c.139C>T	c.(139-141)CGC>TGC	p.R47C	DAPK3_uc002lzd.1_Missense_Mutation_p.R47C	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	47	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GACAGGCGGCGCTTCTTGATG	0.572													24	73					0	0	0	0	A	3964913	A	A	3964913	3	1	120	1	0	0	0	0	1	0	0	0	4254	1087	38	1	1253	1	DAPK3	19	3964913	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08		3964913	55164070	40	21279											
DNMT1	1786	broad.mit.edu	37	chr19	10249194	10249194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gggagcaaacacgtgcagtgGctccgggaacagagggagct	11	4	17	9	2	0	1	0	0	0	1	1	4	1	4	1	4	5	4	1	4	2	0			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr19:10249194G>A	uc002mng.2	-	34	4168	c.3988C>T	c.(3988-3990)CCA>TCA	p.P1330S	DNMT1_uc002mne.2_RNA|DNMT1_uc002mnf.2_Missense_Mutation_p.P254S|DNMT1_uc010xlc.1_Missense_Mutation_p.P1346S|DNMT1_uc002mnh.2_Missense_Mutation_p.P1225S|DNMT1_uc010xld.1_Missense_Mutation_p.P1330S	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1330	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	ACGTGCAGTGGCTCCGGGAAC	0.652													12	57					0	0	0	0	A	10249194	A	A	10249194	3	1	120	1	0	0	0	0	1	0	0	0	4697	1203	42	4	890	4	DNMT1	19	10249194	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08	6284281	10249194	48879789	41	21280											
NOTCH3	4854	broad.mit.edu	37	chr19	15298078	15298078	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagctggcgatgccatccaCgcagcgaccatggtggcatg	9	6	14	12	3	0	0	0	0	0	0	1	3	1	0	3	3	3	3	3	3	1	0			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr19:15298078C>T	uc002nan.2	-	11	1754	c.1678G>A	c.(1678-1680)GTG>ATG	p.V560M	NOTCH3_uc002nao.1_Missense_Mutation_p.V560M	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	560	Extracellular (Potential).|EGF-like 14; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			ATGCCATCCACGCAGCGACCA	0.662													10	36					0	0	0	0	T	15298078	T	T	15298078	3	4	120	1	0	0	0	0	1	0	0	0	10604	536	19	1	5379	1	NOTCH3	19	15298078	Missense_Mutation	SNP	C	TCGA-CR-6470-01A-11D-1870-08	5048884	15298078	43830905	42	21281											
C20orf114	92747	broad.mit.edu	37	chr20	31890213	31890213	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagcatcgggctgatcaatGaaaaggttggtctgtttgcc	10	11	12	8	1	2	2	1	2	1	0	3	2	2	2	1	3	2	4	1	3	4	2			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr20:31890213G>A	uc002wyw.1	+	10	1137	c.976G>A	c.(976-978)GAA>AAA	p.E326K	C20orf114_uc002wyx.1_5'Flank	NM_033197	NP_149974	Q8TDL5	LPLC1_HUMAN	LPLUNC1 protein precursor	326						extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4						GCTGATCAATGAAAAGGTTGG	0.547													12	58					0	0	0	0	A	31890213	A	A	31890213	3	1	120	1	0	0	0	0	1	0	0	0	2092	1291	45	2	1010	2	C20orf114	20	31890213	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08		31890213	31135307	43	21282											
APOL5	80831	broad.mit.edu	37	chr22	36122860	36122860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcttcatgcctaccagatgGccaaatccaactctggcttc	10	11	6	14	0	3	1	1	0	2	1	5	1	4	1	4	2	3	1	4	2	3	3			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr22:36122860G>A	uc003aof.2	+	3	745	c.745G>A	c.(745-747)GCC>ACC	p.A249T		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	249					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						CTACCAGATGGCCAAATCCAA	0.483													4	207					0	0	0	0	A	36122860	A	A	36122860	3	1	120	1	0	0	0	0	1	0	0	0	809	1203	42	4	755	4	APOL5	22	36122860	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08		36122860	15181706	44	21283											
ENTHD1	150350	broad.mit.edu	37	chr22	40283603	40283603	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcatattcataatctctgaGagagaaattgtgttgaaagt	15	13	9	4	0	2	3	1	2	1	2	3	5	2	3	0	0	1	2	0	0	4	5			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr22:40283603G>C	uc003ayg.2	-	2	401	c.150C>G	c.(148-150)CTC>CTG	p.L50L		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	50	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					TAATCTCTGAGAGAGAAATTG	0.423													28	92					0	0	0	0	C	40283603	C	C	40283603	2	2	120	1	0	0	0	0	0	0	0	1	5161	929	33	2		2	ENTHD1	22	40283603	Silent	SNP	G	TCGA-CR-6470-01A-11D-1870-08	4160743	40283603	11020963	45	21284											
EP300	2033	broad.mit.edu	37	chr22	41565529	41565529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtatacatatcttacctcGatagtgttcatttcttccgt	9	17	6	9	2	3	0	1	0	2	0	5	2	4	0	2	0	2	2	2	0	5	8			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr22:41565529G>A	uc003azl.3	+	26	4590	c.4195G>A	c.(4195-4197)GAT>AAT	p.D1399N		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1399				D->Y: Does not interact with TFAP2A and inhibits transcriptional coactivation of TFAP2A by CITED2. Does not inhibit interaction with CITED2, DNA-binding of TFAP2A or nuclear localization of TFAP2A or CITED2.	apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.D1399Y(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ATCTTACCTCGATAGTGTTCA	0.338			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				21	77					0	0	0	0	A	41565529	A	A	41565529	3	1	120	1	0	0	0	0	1	0	0	0	5172	1058	37	1	4297	1	EP300	22	41565529	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08	1281926	41565529	9739037	46	21285											
BRWD3	254065	broad.mit.edu	37	chrX	79979296	79979296	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaaagcagcaaatgtccaTgagaatctgtgcaggcaaaa	18	6	9	8	0	1	1	0	1	1	1	2	2	2	1	1	1	3	4	1	1	6	0			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chrX:79979296T>C	uc004edt.2	-	16	1864	c.1601A>G	c.(1600-1602)CAT>CGT	p.H534R	BRWD3_uc004edo.2_Missense_Mutation_p.H130R|BRWD3_uc004edp.2_Missense_Mutation_p.H363R|BRWD3_uc004edq.2_Missense_Mutation_p.H130R|BRWD3_uc010nmj.1_Missense_Mutation_p.H130R|BRWD3_uc004edr.2_Missense_Mutation_p.H204R|BRWD3_uc004eds.2_Missense_Mutation_p.H130R|BRWD3_uc004edu.2_Missense_Mutation_p.H204R|BRWD3_uc004edv.2_Missense_Mutation_p.H130R|BRWD3_uc004edw.2_Missense_Mutation_p.H130R|BRWD3_uc004edx.2_Missense_Mutation_p.H130R|BRWD3_uc004edy.2_Missense_Mutation_p.H130R|BRWD3_uc004edz.2_Missense_Mutation_p.H204R|BRWD3_uc004eea.2_Missense_Mutation_p.H204R|BRWD3_uc004eeb.2_Missense_Mutation_p.H130R	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	534	WD 9.									ovary(4)	4						CAAATGTCCATGAGAATCTGT	0.303													13	19					0	0	0	0	C	79979296	C	C	79979296	3	2	120	1	0	0	0	0	1	0	0	0	1531	1464	51	5	3911	5	BRWD3	23	79979296	Missense_Mutation	SNP	T	TCGA-CR-6470-01A-11D-1870-08		79979296	75291264	47	21286											
RAB40AL	282808	broad.mit.edu	37	chrX	102192947	102192947	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctaagggcctgaatgccaGgatgatgcgaggcctctcct	8	8	14	11	1	1	2	0	2	1	0	2	4	1	3	4	4	2	1	4	4	2	1			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chrX:102192947G>A	uc004ejs.2	+	1	748	c.701G>A	c.(700-702)AGG>AAG	p.R234K		NM_001031834	NP_001027004	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	234					protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			ovary(2)	2						CTGAATGCCAGGATGATGCGA	0.587													48	49					0	0	0	0	A	102192947	A	A	102192947	3	1	120	1	0	0	0	0	1	0	0	0	13005	1000	35	4	703	4	RAB40AL	23	102192947	Missense_Mutation	SNP	G	TCGA-CR-6470-01A-11D-1870-08	22213651	102192947	53077613	48	21287											
PRAMEF10	343071	broad.mit.edu	37	chr1	12954578	12954578	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaaggctaaaaagagttcAcgaagattgctcatctggct	13	9	10	9	2	3	2	2	0	1	2	3	4	3	2	1	2	1	4	1	2	5	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:12954578A>G	uc001auo.2	-	3	778	c.705T>C	c.(703-705)CGT>CGC	p.R235R		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	235											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAAAGAGTTCACGAAGATTGC	0.488													3	130					0	0	0	0	G	12954578	G	G	12954578	2	3	121	1	0	0	0	0	0	0	0	1	12486	146	6	5		5	PRAMEF10	1	12954578	Silent	SNP	A	TCGA-CR-6471-01A-11D-1870-08		12954578	236296043	1	21288											
EPHA8	2046	broad.mit.edu	37	chr1	22923821	22923821	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcagcacccccacctgtcttCctgcctctgcatcacccccc	5	9	4	23	0	4	0	2	0	2	0	5	0	5	0	8	0	3	2	8	0	0	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:22923821C>T	uc001bfx.1	+	10	1907	c.1782C>T	c.(1780-1782)TTC>TTT	p.F594F		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	594	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CACCTGTCTTCCTGCCTCTGC	0.657													15	48					0	0	0	0	T	22923821	T	T	22923821	2	4	121	1	0	0	0	0	0	0	0	1	5197	854	30	2		2	EPHA8	1	22923821	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	9969243	22923821	226326800	2	21289											
ZBTB8A	653121	broad.mit.edu	37	chr1	33059296	33059296	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattgatgctgaaatggactCtactcctgttggctatcagt	9	14	10	8	0	2	2	1	2	1	0	3	4	3	3	1	2	2	3	1	2	3	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:33059296C>T	uc001bvn.2	+	3	1249	c.764C>T	c.(763-765)TCT>TTT	p.S255F	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_Missense_Mutation_p.S255F	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAATGGACTCTACTCCTGTT	0.438													16	45					0	0	0	0	T	33059296	T	T	33059296	3	4	121	1	0	0	0	0	1	0	0	0	17623	913	32	2	766	2	ZBTB8A	1	33059296	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	10135475	33059296	216191325	3	21290											
KIAA1522	57648	broad.mit.edu	37	chr1	33235677	33235677	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcgccacattgaccgtgtCtaccgggatgacacctttgt	8	10	10	13	3	1	2	0	2	1	0	1	3	1	3	4	1	2	0	4	1	1	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:33235677C>G	uc001bvv.2	+	6	856	c.720C>G	c.(718-720)GTC>GTG	p.V240V	KIAA1522_uc001bvu.1_Silent_p.V299V|KIAA1522_uc010ohm.1_Silent_p.V251V|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	240											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TTGACCGTGTCTACCGGGATG	0.682													19	47					0	0	0	0	G	33235677	G	G	33235677	2	3	121	1	0	0	0	0	0	0	0	1	8277	900	32	2		2	KIAA1522	1	33235677	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	176381	33235677	216014944	4	21291											
MFSD2A	84879	broad.mit.edu	37	chr1	40424394	40424394	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggccctttctctgcctccAtcatcctgtttgtgggccga	3	14	10	14	1	2	0	1	0	1	0	5	1	4	0	5	2	1	1	5	2	0	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:40424394A>G	uc001cev.2	+	3	470	c.289A>G	c.(289-291)ATC>GTC	p.I97V	MFSD2A_uc010ojb.1_Missense_Mutation_p.I47V|MFSD2A_uc001ceu.2_Missense_Mutation_p.I84V|MFSD2A_uc010ojc.1_Intron|MFSD2A_uc009vvy.2_RNA	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	97	Helical; (Potential).				transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						CTCTGCCTCCATCATCCTGTT	0.582													50	152					0	0	0	0	G	40424394	G	G	40424394	3	3	121	1	0	0	0	0	1	0	0	0	9583	217	8	5	299	5	MFSD2A	1	40424394	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	7188717	40424394	208826227	5	21292											
CPT2	1376	broad.mit.edu	37	chr1	53675843	53675843	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccggtttctgaagacacTccgggctggccttctggagc	6	10	12	13	2	2	2	0	1	2	1	4	3	4	3	3	4	1	2	3	4	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:53675843T>A	uc001cvb.3	+	4	1012	c.497T>A	c.(496-498)CTC>CAC	p.L166H		NM_000098	NP_000089	P23786	CPT2_HUMAN	carnitine O-palmitoyltransferase precursor	166	Mitochondrial matrix (By similarity).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity				0					L-Carnitine(DB00583)|Perhexiline(DB01074)	CTGAAGACACTCCGGGCTGGC	0.493													21	51					0	0	0	0	A	53675843	A	A	53675843	3	1	121	1	0	0	0	0	1	0	0	0	3849	1551	54	5	511	5	CPT2	1	53675843	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08	13251449	53675843	195574778	6	21293											
IGSF3	3321	broad.mit.edu	37	chr1	117142910	117142910	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgatacactgcaagtcaaagGagtcgctgtaggtcaccccc	11	8	10	12	1	2	1	2	1	0	0	3	2	2	2	2	2	2	3	2	2	4	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:117142910G>C	uc001egr.1	-	7	2387	c.1682C>G	c.(1681-1683)TCC>TGC	p.S561C	IGSF3_uc001egq.1_Missense_Mutation_p.S581C|IGSF3_uc001egs.1_Missense_Mutation_p.S234C	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	561	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CAAGTCAAAGGAGTCGCTGTA	0.592													18	68					0	0	0	0	C	117142910	C	C	117142910	3	2	121	1	0	0	0	0	1	0	0	0	7640	1174	41	2	1922	2	IGSF3	1	117142910	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	63467067	117142910	132107711	7	21294											
ADAM30	11085	broad.mit.edu	37	chr1	120436723	120436723	+	Frame_Shift_Del	DEL	G	-	-																															attcttcctgtccagtttttGttttagattcttcctgtaca																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:120436723delG	uc001eij.2	-	1	2391	c.2237delC	c.(2236-2238)ACAfs	p.T746fs		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	746	2.|5 X 9 AA approximate repeats.|Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TCCAGTTTTTGTTTTAGATTC	0.353													---	---	---								-	120436723	-	-	120436723	7	5	121	1	0	1	0	1	0	0	0	0	248	1377	48	0	139	0	ADAM30	1	120436723	Frame_Shift_Del	DEL	G	TCGA-CR-6471-01A-11D-1870-08	3293813	120436723	128813898	8	21295											
PDE4DIP	9659	broad.mit.edu	37	chr1	144859816	144859816	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgggaagttctggttaaTggaggaggggctgaggctgg	7	9	21	4	0	1	1	0	1	1	0	1	4	1	4	0	9	0	5	0	9	2	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:144859816T>C	uc001elw.3	-	38	6559	c.6268A>G	c.(6268-6270)ATT>GTT	p.I2090V	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.I1984V|PDE4DIP_uc001elv.3_Missense_Mutation_p.I1097V	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2090					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTCTGGTTAATGGAGGAGGGG	0.577			T	PDGFRB	MPD								7	98					0	0	0	0	C	144859816	C	C	144859816	3	2	121	1	0	0	0	0	1	0	0	0	11697	1464	51	5	800	5	PDE4DIP	1	144859816	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08	24423093	144859816	104390805	9	21296											
NBPF10	100132406	broad.mit.edu	37	chr1	145296440	145296440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaagggagagatgcctcccGctcattgtatgagcatctcc	9	9	12	11	1	2	2	1	1	1	1	4	5	3	4	3	2	2	3	3	2	2	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:145296440G>A	uc001end.3	+	3	397	c.362G>A	c.(361-363)CGC>CAC	p.R121H	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.R121H|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	121											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GATGCCTCCCGCTCATTGTAT	0.562													6	290					0	0	0	0	A	145296440	A	A	145296440	3	1	121	1	0	0	0	0	1	0	0	0	10246	1087	38	1	372	1	NBPF10	1	145296440	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	436624	145296440	103954181	10	21297											
IGSF9	57549	broad.mit.edu	37	chr1	159907550	159907550	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggtccaggaagaacacgCggcactcgtaccagccctgg	9	5	13	14	3	0	1	0	0	0	1	2	2	1	2	3	4	3	3	3	4	3	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:159907550C>T	uc001fur.2	-	4	524	c.326G>A	c.(325-327)CGC>CAC	p.R109H	IGSF9_uc001fuq.2_Missense_Mutation_p.R109H	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	109	Ig-like 1.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GAAGAACACGCGGCACTCGTA	0.602													18	60					0	0	0	0	T	159907550	T	T	159907550	3	4	121	1	0	0	0	0	1	0	0	0	7644	768	27	1	3285	1	IGSF9	1	159907550	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	14611110	159907550	89343071	11	21298											
DCAF6	55827	broad.mit.edu	37	chr1	168014380	168014380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgaagaaacatccaccaggGactctgctcttcaggacaca	14	7	8	12	0	3	2	1	1	2	1	4	4	4	4	2	2	2	1	2	2	2	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:168014380G>A	uc001gew.2	+	14	2184	c.1942G>A	c.(1942-1944)GAC>AAC	p.D648N	DCAF6_uc001gev.2_Missense_Mutation_p.D668N|DCAF6_uc001gex.2_Missense_Mutation_p.D725N|DCAF6_uc010plk.1_Missense_Mutation_p.D694N|DCAF6_uc001gey.2_Missense_Mutation_p.D521N|DCAF6_uc001gez.2_5'UTR	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	648					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ATCCACCAGGGACTCTGCTCT	0.483													13	28					0	0	0	0	A	168014380	A	A	168014380	3	1	121	1	0	0	0	0	1	0	0	0	4291	1174	41	2	2060	2	DCAF6	1	168014380	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	8106830	168014380	81236241	12	21299											
CACNA1E	777	broad.mit.edu	37	chr1	181702754	181702754	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgcagctagacatgggcCgggtcatcagccagagcgag	10	6	15	10	2	2	2	2	0	0	2	2	3	2	2	2	2	4	2	2	2	1	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:181702754C>T	uc001gow.2	+	21	3295	c.3130C>T	c.(3130-3132)CGG>TGG	p.R1044W	CACNA1E_uc009wxs.2_Missense_Mutation_p.R932W|CACNA1E_uc001gox.1_Missense_Mutation_p.R270W|CACNA1E_uc009wxt.2_Missense_Mutation_p.R270W	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1044	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AGACATGGGCCGGGTCATCAG	0.647													6	17					0	0	0	0	T	181702754	T	T	181702754	3	4	121	1	0	0	0	0	1	0	0	0	2554	643	23	1	3212	1	CACNA1E	1	181702754	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	13688374	181702754	67547867	13	21300											
KCNT2	343450	broad.mit.edu	37	chr1	196309633	196309633	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtagaattcataatgtatcGaggacctggattcagcaaaa	15	11	9	6	1	2	1	2	0	0	1	3	4	2	3	1	2	1	3	1	2	6	5			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:196309633G>A	uc001gtd.1	-	16	1681	c.1621C>T	c.(1621-1623)CGA>TGA	p.R541*	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Nonsense_Mutation_p.R491*|KCNT2_uc001gtf.1_Nonsense_Mutation_p.R541*|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Nonsense_Mutation_p.R541*|KCNT2_uc001gth.1_Nonsense_Mutation_p.R62*	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	541	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						ATAATGTATCGAGGACCTGGA	0.323													21	53					0	0	0	0	A	196309633	A	A	196309633	4	1	121	1	0	0	0	0	0	1	0	0	8131	1066	37	1	1838	1	KCNT2	1	196309633	Nonsense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	14606879	196309633	52940988	14	21301											
CACNA1S	779	broad.mit.edu	37	chr1	201042688	201042688	+	Frame_Shift_Del	DEL	T	-	-																															ggtgctcaccttggcagtggTggggatgccctcacccttgg																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:201042688delT	uc001gvv.2	-	15	2373	c.2146delA	c.(2146-2148)ACCfs	p.T716fs		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	716	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTGGCAGTGGTGGGGATGCCC	0.552													---	---	---								-	201042688	-	-	201042688	7	5	121	1	0	1	0	1	0	0	0	0	2559	1696	59	0	3595	0	CACNA1S	1	201042688	Frame_Shift_Del	DEL	T	TCGA-CR-6471-01A-11D-1870-08	4733055	201042688	48207933	15	21302											
FAM71A	149647	broad.mit.edu	37	chr1	212799632	212799632	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccacagagccaatagagaTgacaaaaaggagaaaggctg	19	3	12	7	0	0	4	0	1	0	3	0	6	0	4	2	2	2	1	2	2	5	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:212799632T>G	uc001hjk.2	+	1	1817	c.1413T>G	c.(1411-1413)GAT>GAG	p.D471E	uc010pth.1_RNA	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	471										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CCAATAGAGATGACAAAAAGG	0.557													20	44					0	0	0	0	G	212799632	G	G	212799632	3	3	121	1	0	0	0	0	1	0	0	0	5639	1461	51	5	1415	5	FAM71A	1	212799632	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08	11756944	212799632	36450989	16	21303											
MARK1	4139	broad.mit.edu	37	chr1	220805593	220805593	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgaaataaatgatgccttaAtaaatcagaagtatgatgaa	20	11	7	3	0	1	5	1	4	0	1	1	5	1	5	1	0	1	1	1	0	9	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:220805593A>G	uc001hmn.3	+	11	1657	c.1060A>G	c.(1060-1062)ATA>GTA	p.I354V	MARK1_uc009xdw.2_Missense_Mutation_p.I354V|MARK1_uc010pun.1_Missense_Mutation_p.I354V|MARK1_uc001hmm.3_Missense_Mutation_p.I332V	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	354	UBA.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		TGATGCCTTAATAAATCAGAA	0.299													70	218					0	0	0	0	G	220805593	G	G	220805593	3	3	121	1	0	0	0	0	1	0	0	0	9365	101	4	5	1102	5	MARK1	1	220805593	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	8005961	220805593	28445028	17	21304											
SNAP47	116841	broad.mit.edu	37	chr1	227935613	227935613	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catagttgagatcaagaaggAggcttcacattttatcttca	13	13	8	7	0	4	2	3	1	1	2	4	4	4	3	0	2	0	2	0	2	4	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:227935613A>T	uc001hrf.2	+	2	725	c.311A>T	c.(310-312)GAG>GTG	p.E104V	SNAP47_uc001hqz.2_Missense_Mutation_p.E59V|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_Missense_Mutation_p.E104V|SNAP47_uc001hre.2_Intron|SNAP47_uc001hrg.1_Missense_Mutation_p.E59V	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	104						endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						ATCAAGAAGGAGGCTTCACAT	0.527													20	48					0	0	0	0	T	227935613	T	T	227935613	3	4	121	1	0	0	0	0	1	0	0	0	14896	304	11	5	317	5	SNAP47	1	227935613	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	7130020	227935613	21315008	18	21305											
EXO1	9156	broad.mit.edu	37	chr1	242020736	242020736	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacaaagcgggaattgtgcaAgccataattacagaggactc	16	7	10	8	1	0	1	0	0	0	1	1	3	0	3	1	2	5	1	1	2	6	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:242020736A>G	uc001hzh.2	+	7	1035	c.495A>G	c.(493-495)CAA>CAG	p.Q165Q	EXO1_uc001hzi.2_Silent_p.Q165Q|EXO1_uc001hzj.2_Silent_p.Q165Q|EXO1_uc009xgq.2_Silent_p.Q165Q	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	165	I-domain.|Interaction with MSH3.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			GAATTGTGCAAGCCATAATTA	0.458								Direct_reversal_of_damage|Editing_and_processing_nucleases					20	59					0	0	0	0	G	242020736	G	G	242020736	2	3	121	1	0	0	0	0	0	0	0	1	5324	69	3	5		5	EXO1	1	242020736	Silent	SNP	A	TCGA-CR-6471-01A-11D-1870-08	14085123	242020736	7229885	19	21306											
OR2L13	284521	broad.mit.edu	37	chr1	248262997	248262997	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcttcttcctgaccatggCgtgttctgaaggcttactcc	5	15	8	13	1	3	2	0	2	3	0	5	2	5	2	3	2	1	2	3	2	2	5			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr1:248262997C>T	uc001ids.2	+	3	657	c.320C>T	c.(319-321)GCG>GTG	p.A107V		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding	p.A107V(1)		central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CTGACCATGGCGTGTTCTGAA	0.517													66	224					0	0	0	0	T	248262997	T	T	248262997	3	4	121	1	0	0	0	0	1	0	0	0	11060	768	27	1	322	1	OR2L13	1	248262997	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	6242261	248262997	987624	20	21307											
RBKS	64080	broad.mit.edu	37	chr2	28081341	28081341	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtcattgctccaagccgagCagcttggacacactggttgg	8	9	12	12	2	1	0	1	0	0	0	2	2	2	1	2	3	4	4	2	3	1	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:28081341C>A	uc002rlo.1	-	2	198	c.187G>T	c.(187-189)GCT>TCT	p.A63S	RBKS_uc010ezi.1_5'UTR|RBKS_uc010ymg.1_Missense_Mutation_p.A63S	NM_022128	NP_071411	Q9H477	RBSK_HUMAN	ribokinase	63					D-ribose metabolic process		ATP binding|ribokinase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)					CCAAGCCGAGCAGCTTGGACA	0.438													18	56					5.01169e-05	5.19634e-05	1	0	A	28081341	A	A	28081341	3	1	121	1	0	0	0	0	1	0	0	0	13173	710	25	4	809	4	RBKS	2	28081341	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08		28081341	215118032	21	21308											
XDH	7498	broad.mit.edu	37	chr2	31562418	31562418	+	Frame_Shift_Del	DEL	G	-	-																															agggacaccctgaactcaatGgggatgctgccaaatgccgg																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:31562418delG	uc002rnv.1	-	34	3790	c.3711delC	c.(3709-3711)CCCfs	p.P1237fs		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1237					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGAACTCAATGGGGATGCTGC	0.577													---	---	---								-	31562418	-	-	31562418	7	5	121	1	0	1	0	1	0	0	0	0	17494	1335	47	0	302	0	XDH	2	31562418	Frame_Shift_Del	DEL	G	TCGA-CR-6471-01A-11D-1870-08	3481077	31562418	211636955	22	21309											
LTBP1	4052	broad.mit.edu	37	chr2	33540271	33540271	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggagtgcctaaacacagAgggttctttccattgtgtct	9	12	12	8	0	2	1	0	0	2	1	3	2	3	2	2	3	2	1	2	3	2	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:33540271A>G	uc002ros.2	+	24	3668	c.3668A>G	c.(3667-3669)GAG>GGG	p.E1223G	LTBP1_uc002rot.2_Missense_Mutation_p.E897G|LTBP1_uc002rou.2_Missense_Mutation_p.E896G|LTBP1_uc002rov.2_Missense_Mutation_p.E843G|LTBP1_uc010ymz.1_Missense_Mutation_p.E896G|LTBP1_uc010yna.1_Missense_Mutation_p.E843G|LTBP1_uc010ynb.1_Missense_Mutation_p.E162G	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1222	EGF-like 12; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CTAAACACAGAGGGTTCTTTC	0.408													11	44					0	0	0	0	G	33540271	G	G	33540271	3	3	121	1	0	0	0	0	1	0	0	0	9123	304	11	5	3814	5	LTBP1	2	33540271	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	1977853	33540271	209659102	23	21310											
DPP10	57628	broad.mit.edu	37	chr2	116503737	116503737	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctcacactttggagctcatgCcacctgacagctttaaatca	11	11	6	13	0	3	1	3	1	0	0	3	2	3	2	2	1	3	2	2	1	2	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:116503737C>T	uc002tla.1	+	10	1385	c.928C>T	c.(928-930)CCA>TCA	p.P310S	DPP10_uc002tlb.1_Missense_Mutation_p.P260S|DPP10_uc002tlc.1_Missense_Mutation_p.P306S|DPP10_uc002tle.2_Missense_Mutation_p.P314S|DPP10_uc002tlf.1_Missense_Mutation_p.P303S	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	310	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						GGAGCTCATGCCACCTGACAG	0.343													3	40					0	0	0	0	T	116503737	T	T	116503737	3	4	121	1	0	0	0	0	1	0	0	0	4749	739	26	4	1137	4	DPP10	2	116503737	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	82963466	116503737	126695636	24	21311											
ARHGAP15	55843	broad.mit.edu	37	chr2	143913112	143913112	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaacactgaattctacccGccaaggcacaggagctgtgc	12	6	11	12	1	1	1	0	1	1	0	1	3	1	3	2	3	4	2	2	3	4	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:143913112G>A	uc002tvm.3	+	2	204	c.53G>A	c.(52-54)CGC>CAC	p.R18H	ARHGAP15_uc010zbl.1_Missense_Mutation_p.R18H	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	18					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		AATTCTACCCGCCAAGGCACA	0.398													9	23					0	0	0	0	A	143913112	A	A	143913112	3	1	121	1	0	0	0	0	1	0	0	0	866	1087	38	1	55	1	ARHGAP15	2	143913112	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	27409375	143913112	99286261	25	21312											
SLC4A10	57282	broad.mit.edu	37	chr2	162696359	162696359	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggatgatgacgaggaacacaTtcctcatgaccttttcacag	12	10	9	10	1	2	3	2	3	0	0	3	6	3	5	2	2	1	0	2	2	1	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:162696359T>A	uc002ubx.3	+	4	522	c.338T>A	c.(337-339)ATT>AAT	p.I113N	SLC4A10_uc010fpa.1_Missense_Mutation_p.I125N|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.I113N|SLC4A10_uc010zcs.1_Missense_Mutation_p.I124N	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	113	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						GAGGAACACATTCCTCATGAC	0.438													19	57					0	0	0	0	A	162696359	A	A	162696359	3	1	121	1	0	0	0	0	1	0	0	0	14715	1493	52	5	437	5	SLC4A10	2	162696359	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08	18783247	162696359	80503014	26	21313											
OSBPL6	114880	broad.mit.edu	37	chr2	179197685	179197685	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgaaattgtgagatcaccaAgagatgctagttttcacata	15	12	8	6	0	2	3	2	2	0	2	2	5	2	3	1	0	1	2	1	0	4	5			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:179197685A>T	uc002ulx.2	+	8	952	c.574A>T	c.(574-576)AGA>TGA	p.R192*	OSBPL6_uc002ulw.2_Nonsense_Mutation_p.R192*|OSBPL6_uc002uly.2_Nonsense_Mutation_p.R192*|OSBPL6_uc010zfe.1_Nonsense_Mutation_p.R192*|OSBPL6_uc002ulz.2_Nonsense_Mutation_p.R192*|OSBPL6_uc002uma.2_Nonsense_Mutation_p.R171*	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	192					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			GAGATCACCAAGAGATGCTAG	0.413													25	71					0	0	0	0	T	179197685	T	T	179197685	4	4	121	1	0	0	0	0	0	1	0	0	11335	64	3	5	639	5	OSBPL6	2	179197685	Nonsense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	16501326	179197685	64001688	27	21314											
TTN	7273	broad.mit.edu	37	chr2	179473617	179473617	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcttcaaatacaaagttgAttggtggtcccggtgtatct	10	15	9	7	1	3	1	1	1	2	0	4	1	4	1	1	3	1	2	1	3	5	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:179473617A>T	uc010zfg.1	-	223	44641	c.44417T>A	c.(44416-44418)ATC>AAC	p.I14806N	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I8501N|TTN_uc010zfi.1_Missense_Mutation_p.I8434N|TTN_uc010zfj.1_Missense_Mutation_p.I8309N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15733							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACAAAGTTGATTGGTGGTCC	0.388													31	116					0	0	0	0	T	179473617	T	T	179473617	3	4	121	1	0	0	0	0	1	0	0	0	16803	333	12	5	55928	5	TTN	2	179473617	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	275932	179473617	63725756	28	21315											
MARS2	92935	broad.mit.edu	37	chr2	198571571	198571571	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccgtgtccagctgtgtccGgcaaactaatggttttgtcc	6	12	12	11	2	0	0	0	0	0	0	3	0	3	0	4	3	2	3	4	3	2	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:198571571G>A	uc002uuq.2	+	1	1485	c.1442G>A	c.(1441-1443)CGG>CAG	p.R481Q	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	481					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	AGCTGTGTCCGGCAAACTAAT	0.542													32	104					0	0	0	0	A	198571571	A	A	198571571	3	1	121	1	0	0	0	0	1	0	0	0	9370	1116	39	1	1444	1	MARS2	2	198571571	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	19097954	198571571	44627802	29	21316											
ERBB4	2066	broad.mit.edu	37	chr2	212295727	212295727	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaagagtctggctagcccAaaatctgtgattttcacatg	11	12	8	10	0	3	2	1	1	2	1	4	2	4	2	2	1	1	1	2	1	4	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:212295727A>C	uc002veg.1	-	21	2684	c.2586T>G	c.(2584-2586)TTT>TTG	p.F862L	ERBB4_uc002veh.1_Missense_Mutation_p.F862L|ERBB4_uc010zji.1_Missense_Mutation_p.F852L|ERBB4_uc010zjj.1_Missense_Mutation_p.F852L	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	862	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TGGCTAGCCCAAAATCTGTGA	0.418										TSP Lung(8;0.080)			3	104					0	0	0	0	C	212295727	C	C	212295727	3	2	121	1	0	0	0	0	1	0	0	0	5233	127	5	5	1372	5	ERBB4	2	212295727	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	13724156	212295727	30903646	30	21317											
ABCB6	10058	broad.mit.edu	37	chr2	220080750	220080750	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgacactggatgtgccccGatccgcgatccgcagcacct	7	8	11	15	4	0	1	0	1	0	0	2	4	2	2	5	1	2	2	5	1	0	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:220080750G>A	uc002vkc.1	-	5	1400	c.1123C>T	c.(1123-1125)CGG>TGG	p.R375W	ABCB6_uc010fwe.1_Missense_Mutation_p.R329W|ABCB6_uc010zku.1_Intron	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	375	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GATGTGCCCCGATCCGCGATC	0.687													4	16					0	0	0	0	A	220080750	A	A	220080750	3	1	121	1	0	0	0	0	1	0	0	0	45	1057	37	1	1465	1	ABCB6	2	220080750	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	7785023	220080750	23118623	31	21318											
KCNE4	23704	broad.mit.edu	37	chr2	223917672	223917672	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtacttctacattctggttGtcatgtccttctacggcatt	7	17	7	10	1	4	0	1	0	3	0	5	0	5	0	1	2	3	3	1	2	3	8			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:223917672G>T	uc002vnl.3	+	2	278	c.124G>T	c.(124-126)GTC>TTC	p.V42F		NM_080671	NP_542402	Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related	42	Helical; (Potential).					integral to membrane	voltage-gated potassium channel activity			ovary(1)	1		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		CATTCTGGTTGTCATGTCCTT	0.597													24	82					2.98393e-07	3.19475e-07	1	0	T	223917672	T	T	223917672	3	4	121	1	0	0	0	0	1	0	0	0	8064	1377	48	4	126	4	KCNE4	2	223917672	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	3836922	223917672	19281701	32	21319											
SERPINE2	5270	broad.mit.edu	37	chr2	224866605	224866605	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccaagaggaagagggggaGatgccagttcatggttcctt	10	8	16	7	0	1	3	1	0	0	3	2	5	2	4	3	5	1	2	3	5	2	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:224866605G>A	uc002vnu.2	-	2	256	c.13C>T	c.(13-15)CTC>TTC	p.L5F	SERPINE2_uc002vnt.2_Missense_Mutation_p.L5F|SERPINE2_uc010zlr.1_Missense_Mutation_p.L17F|SERPINE2_uc002vnv.2_Missense_Mutation_p.L5F	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	5					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		AAGAGGGGGAGATGCCAGTTC	0.443													33	66					0	0	0	0	A	224866605	A	A	224866605	3	1	121	1	0	0	0	0	1	0	0	0	14177	942	33	2	1215	2	SERPINE2	2	224866605	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	948933	224866605	18332768	33	21320											
B3GNT7	93010	broad.mit.edu	37	chr2	232262638	232262638	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacccgaaagatgtggctGcgcccacgcccatggcctct	9	6	11	15	3	1	2	0	0	1	2	1	3	1	2	4	2	2	1	4	2	2	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr2:232262638G>T	uc002vrs.2	+	2	388	c.208G>T	c.(208-210)GCG>TCG	p.A70S		NM_145236	NP_660279	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal	70	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		AGATGTGGCTGCGCCCACGCC	0.617													10	35					2.17888e-05	2.2711e-05	1	0	T	232262638	T	T	232262638	3	4	121	1	0	0	0	0	1	0	0	0	1264	1319	46	4	214	4	B3GNT7	2	232262638	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	7396033	232262638	10936735	34	21321											
TRIM71	131405	broad.mit.edu	37	chr3	32931915	32931915	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggtggagaagctgcggcaaAacctcaacaagcttgagagc	14	5	13	9	1	1	2	1	1	0	2	1	4	1	2	1	3	6	3	1	3	5	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:32931915A>C	uc003cff.2	+	4	1282	c.1219A>C	c.(1219-1221)AAC>CAC	p.N407H		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	407	Potential.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						GCTGCGGCAAAACCTCAACAA	0.567													27	83					0	0	0	0	C	32931915	C	C	32931915	3	2	121	1	0	0	0	0	1	0	0	0	16611	14	1	5	1233	5	TRIM71	3	32931915	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08		32931915	165090515	35	21322											
SUSD5	26032	broad.mit.edu	37	chr3	33255548	33255548	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaaagccgagcagcctcCagttgtaggccctgagagcc	10	5	13	13	1	0	1	0	1	0	1	1	4	1	2	5	2	4	3	5	2	2	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:33255548C>T	uc003cfo.1	-	2	580	c.162G>A	c.(160-162)CTG>CTA	p.L54L		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	54	Extracellular (Potential).|Link.				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						GAGCAGCCTCCAGTTGTAGGC	0.547													5	28					0	0	0	0	T	33255548	T	T	33255548	2	4	121	1	0	0	0	0	0	0	0	1	15477	581	21	4		4	SUSD5	3	33255548	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	323633	33255548	164766882	36	21323											
SETD2	29072	broad.mit.edu	37	chr3	47163558	47163558	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagctgaactagtgctaccGatgctctgcttatattcttc	9	14	8	10	1	2	1	0	1	2	0	3	3	2	1	1	0	6	4	1	0	6	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:47163558G>A	uc003cqs.2	-	3	2621	c.2568C>T	c.(2566-2568)ATC>ATT	p.I856I	SETD2_uc003cqv.2_Silent_p.I845I	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	856					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TAGTGCTACCGATGCTCTGCT	0.358			N|F|S|Mis		clear cell renal carcinoma								13	42					0	0	0	0	A	47163558	A	A	47163558	2	1	121	1	0	0	0	0	0	0	0	1	14196	1048	37	1		1	SETD2	3	47163558	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	13908010	47163558	150858872	37	21324											
ATRIP	84126	broad.mit.edu	37	chr3	48501802	48501802	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagcacctggggactcacCgacacattcctcctgcgtga	8	7	11	15	3	1	1	1	1	0	0	3	4	3	3	4	3	2	1	4	3	0	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:48501802C>T	uc003ctf.1	+	8	1381	c.1349C>T	c.(1348-1350)CCG>CTG	p.P450L	ATRIP_uc011bbj.1_Missense_Mutation_p.P323L|ATRIP_uc003ctg.1_Missense_Mutation_p.P450L|TREX1_uc010hjy.2_5'UTR	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	450					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGGGACTCACCGACACATTCC	0.562								Other_conserved_DNA_damage_response_genes					15	59					0	0	0	0	T	48501802	T	T	48501802	3	4	121	1	0	0	0	0	1	0	0	0	1207	652	23	1	1379	1	ATRIP	3	48501802	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	1338244	48501802	149520628	38	21325											
OR5H6	79295	broad.mit.edu	37	chr3	97983874	97983874	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaaaagaagtctatcaaagGgatacgaaaagctgtctcca	18	7	9	7	1	3	2	1	0	2	2	4	4	3	3	1	1	2	1	1	1	8	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:97983874G>A	uc003dsi.1	+	1	746	c.746G>A	c.(745-747)GGG>GAG	p.G249E		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	249	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G249G(1)		skin(2)|large_intestine(1)	3						TCTATCAAAGGGATACGAAAA	0.383													7	39					0	0	0	0	A	97983874	A	A	97983874	3	1	121	1	0	0	0	0	1	0	0	0	11217	1232	43	4	748	4	OR5H6	3	97983874	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	49482072	97983874	100038556	39	21326											
OR5H2	79310	broad.mit.edu	37	chr3	98001947	98001947	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttcttgggagtttagcCtttgttgatgcttggatatc	5	21	10	5	0	1	1	0	1	1	0	2	3	1	3	1	2	2	3	1	2	2	10			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:98001947C>G	uc003dsj.1	+	1	216	c.216C>G	c.(214-216)GCC>GCG	p.A72A		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						GGAGTTTAGCCTTTGTTGATG	0.393													50	210					0	0	0	0	G	98001947	G	G	98001947	2	3	121	1	0	0	0	0	0	0	0	1	11216	668	24	4		4	OR5H2	3	98001947	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	18073	98001947	100020483	40	21327											
PIK3CA	5290	broad.mit.edu	37	chr3	178916876	178916876	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attttttgatgaaacaagacGactttgtgaccttcggcttt	10	16	8	7	2	0	4	0	3	0	1	1	5	0	4	1	1	1	1	1	1	2	6	rs121913287		TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:178916876G>A	uc003fjk.2	+	2	420	c.263G>A	c.(262-264)CGA>CAA	p.R88Q		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	88	PI3K-ABD.		R -> Q (in cancer; may disrupt the interaction between the PI3K-ABD domain and the N-terminal lobe of PI3K/PI4K kinase domain possibly affecting the conformation of the kinase domain).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R88Q(26)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAACAAGACGACTTTGTGAC	0.363	R88Q(SKUT1_SOFT_TISSUE)|R88Q(JHUEM1_ENDOMETRIUM)|R88Q(SNGM_ENDOMETRIUM)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			16	62					0	0	0	0	A	178916876	A	A	178916876	3	1	121	1	0	0	0	0	1	0	0	0	11968	1058	37	1	265	1	PIK3CA	3	178916876	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	80914929	178916876	19105554	41	21328											
PIK3CA	5290	broad.mit.edu	37	chr3	178952072	178952072	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggagtatttcatgaaacaaAtgaatgatgcacatcatggt	15	12	9	5	0	2	3	2	3	0	0	2	4	2	4	0	2	2	2	0	2	4	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:178952072A>G	uc003fjk.2	+	21	3284	c.3127A>G	c.(3127-3129)ATG>GTG	p.M1043V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1043	PI3K/PI4K.		M -> I (in cancer; shows an increase in lipid kinase activity).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.M1043I(31)|p.M1043V(15)|p.M1043T(3)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CATGAAACAAATGAATGATGC	0.368		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			14	42					0	0	0	0	G	178952072	G	G	178952072	3	3	121	1	0	0	0	0	1	0	0	0	11968	101	4	5	3205	5	PIK3CA	3	178952072	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	35196	178952072	19070358	42	21329											
VPS8	23355	broad.mit.edu	37	chr3	184714191	184714191	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgtaacctgagagcttcGgtcaccagaggactgaatcc	10	10	11	10	1	1	3	1	2	0	2	3	5	2	4	3	2	2	2	3	2	2	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:184714191G>T	uc003fpb.1	+	43	3903	c.3732G>T	c.(3730-3732)TCG>TCT	p.S1244S	VPS8_uc010hyd.1_Silent_p.S1154S|VPS8_uc010hye.1_Silent_p.S673S	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1246							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TGAGAGCTTCGGTCACCAGAG	0.413													21	32					1.96292e-10	2.14831e-10	1	0	T	184714191	T	T	184714191	2	4	121	1	0	0	0	0	0	0	0	1	17286	1103	39	3		3	VPS8	3	184714191	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	5762119	184714191	13308239	43	21330											
LPP	4026	broad.mit.edu	37	chr3	188242516	188242516	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggacgctgagattgactccTtgaccagcatcttggctgac	8	11	11	11	1	1	4	0	4	1	1	2	6	2	5	2	2	1	3	2	2	0	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:188242516T>C	uc003frs.1	+	5	616	c.370T>C	c.(370-372)TTG>CTG	p.L124L	LPP_uc011bsg.1_Silent_p.L124L|LPP_uc011bsi.1_Silent_p.L124L|LPP_uc003frt.2_Silent_p.L124L	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	124	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GATTGACTCCTTGACCAGCAT	0.547			T	HMGA2|MLL|C12orf9	lipoma|leukemia								42	100					0	0	0	0	C	188242516	C	C	188242516	2	2	121	1	0	0	0	0	0	0	0	1	8973	1606	56	5		5	LPP	3	188242516	Silent	SNP	T	TCGA-CR-6471-01A-11D-1870-08	3528325	188242516	9779914	44	21331											
CPN2	1370	broad.mit.edu	37	chr3	194061983	194061983	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acggtgccctcggggttgctGtaggtgcactggctccgggc	3	9	17	12	3	0	0	0	0	0	0	2	0	1	0	2	6	3	5	2	6	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr3:194061983G>A	uc003fts.2	-	2	1539	c.1449C>T	c.(1447-1449)TAC>TAT	p.Y483Y		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	483					protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		CGGGGTTGCTGTAGGTGCACT	0.662													19	37					0	0	0	0	A	194061983	A	A	194061983	2	1	121	1	0	0	0	0	0	0	0	1	3825	1372	48	4		4	CPN2	3	194061983	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	5819467	194061983	3960447	45	21332											
DHX15	1665	broad.mit.edu	37	chr4	24550530	24550530	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggtggaggctcaaaaatgCgttgctgctgctgaggtgga	9	9	17	6	1	1	1	1	1	0	0	1	4	1	3	0	5	4	5	0	5	2	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr4:24550530C>T	uc003gqx.2	-	6	1364	c.1196G>A	c.(1195-1197)CGC>CAC	p.R399H		NM_001358	NP_001349	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 15	399	Helicase C-terminal.				mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(1)	1		Breast(46;0.0503)				CTCAAAAATGCGTTGCTGCTG	0.363													11	37					0	0	0	0	T	24550530	T	T	24550530	3	4	121	1	0	0	0	0	1	0	0	0	4523	768	27	1	1227	1	DHX15	4	24550530	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08		24550530	166603746	46	21333											
WDR19	57728	broad.mit.edu	37	chr4	39217514	39217514	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgctagcactctctaccCaaaggggctcacttcatgtt	9	12	8	12	0	3	0	2	0	1	0	4	0	3	0	1	2	3	5	1	2	3	5			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr4:39217514C>G	uc003gtv.2	+	11	1169	c.1015C>G	c.(1015-1017)CAA>GAA	p.Q339E	WDR19_uc010ifl.1_Missense_Mutation_p.Q156E|WDR19_uc003gtu.1_Missense_Mutation_p.Q339E|WDR19_uc011byi.1_Missense_Mutation_p.Q179E|WDR19_uc003gtw.1_5'UTR	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	339	WD 6.				cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						ACTCTCTACCCAAAGGGGCTC	0.448													20	56					0	0	0	0	G	39217514	G	G	39217514	3	3	121	1	0	0	0	0	1	0	0	0	17347	595	21	4	1057	4	WDR19	4	39217514	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	14666984	39217514	151936762	47	21334											
PDGFRA	5156	broad.mit.edu	37	chr4	55141026	55141026	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaaaccgaggtatgaaattCgctggagggtcattgaatca	14	9	12	6	2	2	3	2	2	0	1	3	5	2	4	1	3	1	2	1	3	4	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr4:55141026C>T	uc003han.3	+	12	2003	c.1672C>T	c.(1672-1674)CGC>TGC	p.R558C	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.R452C|PDGFRA_uc003ham.2_RNA|PDGFRA_uc003hao.1_5'Flank	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	558	Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTATGAAATTCGCTGGAGGGT	0.463			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			22	50					0	0	0	0	T	55141026	T	T	55141026	3	4	121	1	0	0	0	0	1	0	0	0	11715	884	31	1	1714	1	PDGFRA	4	55141026	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	15923512	55141026	136013250	48	21335											
ALB	213	broad.mit.edu	37	chr4	74284002	74284002	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatatatgcacactttctgaGaaggagagacaaatcaagaa	18	8	9	6	0	2	3	1	1	1	3	2	7	2	4	0	1	1	1	0	1	6	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr4:74284002G>A	uc003hgs.3	+	12	1699	c.1626G>A	c.(1624-1626)GAG>GAA	p.E542E	ALB_uc003hgw.3_Silent_p.E350E|ALB_uc011cbe.1_Silent_p.E221E|ALB_uc003hgt.3_Silent_p.E542E|ALB_uc010iii.2_Silent_p.E427E|ALB_uc003hgu.3_Silent_p.E392E|ALB_uc003hgv.3_Silent_p.E221E|ALB_uc011cbf.1_Silent_p.E432E|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Silent_p.E221E	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	542	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CACTTTCTGAGAAGGAGAGAC	0.388													12	51					0	0	0	0	A	74284002	A	A	74284002	2	1	121	1	0	0	0	0	0	0	0	1	486	933	33	2		2	ALB	4	74284002	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	19142976	74284002	116870274	49	21336											
HELQ	113510	broad.mit.edu	37	chr4	84368164	84368164	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacaaagaaaccgagttctaTaccaaaacttgacaaacctg	19	7	5	10	1	1	2	0	1	1	1	1	3	1	2	3	0	5	1	3	0	8	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr4:84368164T>C	uc003hom.2	-	4	1395	c.1216A>G	c.(1216-1218)ATA>GTA	p.I406V	HELQ_uc010ikb.2_Intron|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	406	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						CCGAGTTCTATACCAAAACTT	0.239								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					9	25					0	0	0	0	C	84368164	C	C	84368164	3	2	121	1	0	0	0	0	1	0	0	0	7086	1406	49	5	2149	5	HELQ	4	84368164	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08	10084162	84368164	106786112	50	21337											
BDH2	56898	broad.mit.edu	37	chr4	104017355	104017355	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttactaaggcagctgcttgGccaatcccctgagcagcggc	8	8	11	14	1	0	1	0	1	0	0	1	1	1	1	3	3	5	4	3	3	3	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr4:104017355G>C	uc003hwz.2	-	2	162	c.57C>G	c.(55-57)GGC>GGG	p.G19G	BDH2_uc003hxa.2_RNA	NM_020139	NP_064524	Q9BUT1	BDH2_HUMAN	3-hydroxybutyrate dehydrogenase, type 2	19	NAD.				fatty acid beta-oxidation|heme metabolic process|iron ion homeostasis|siderophore biosynthetic process	cytoplasm	3-hydroxybutyrate dehydrogenase activity|NAD binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.02e-08)		CAGCTGCTTGGCCAATCCCCT	0.423													11	24					0	0	0	0	C	104017355	C	C	104017355	2	2	121	1	0	0	0	0	0	0	0	1	1393	1190	42	4		4	BDH2	4	104017355	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	19649191	104017355	87136921	51	21338											
INPP4B	8821	broad.mit.edu	37	chr4	143003331	143003331	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacgaataccattcagtttgCggcaaatctgtaacatatgt	14	12	7	8	2	2	0	1	0	1	0	2	1	2	0	1	1	4	3	1	1	6	5			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr4:143003331C>A	uc003iix.3	-	26	3090	c.2495G>T	c.(2494-2496)CGC>CTC	p.R832L	INPP4B_uc003iiw.3_Missense_Mutation_p.R832L|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Missense_Mutation_p.R647L|INPP4B_uc011cho.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	832					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					ATTCAGTTTGCGGCAAATCTG	0.403													11	45					0.00136819	0.00141117	1	0	A	143003331	A	A	143003331	3	1	121	1	0	0	0	0	1	0	0	0	7792	768	27	3	287	3	INPP4B	4	143003331	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	38985976	143003331	48150945	52	21339											
IRX2	153572	broad.mit.edu	37	chr5	2748625	2748625	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccctggccctgcagcgccgcGttcaagttcccgtagtttgt	4	11	11	15	4	1	0	1	0	0	0	2	0	2	0	4	1	2	5	4	1	2	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:2748625G>A	uc003jda.2	-	3	1439	c.1197C>T	c.(1195-1197)AAC>AAT	p.N399N	IRX2_uc003jdb.2_Silent_p.N399N	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	399						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		GCAGCGCCGCGTTCAAGTTCC	0.711													21	67					0	0	0	0	A	2748625	A	A	2748625	2	1	121	1	0	0	0	0	0	0	0	1	7883	1136	40	1		1	IRX2	5	2748625	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08		2748625	178166635	53	21340											
DNAH5	1767	broad.mit.edu	37	chr5	13839478	13839478	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccatcacctgtctgtaagtgGagttattacaagcctgtcag	10	12	9	10	0	3	0	2	0	1	0	3	1	3	1	3	1	2	2	3	1	4	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:13839478G>A	uc003jfd.2	-	35	5911	c.5869C>T	c.(5869-5871)CCA>TCA	p.P1957S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1957	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTGTAAGTGGAGTTATTACA	0.418									Kartagener_syndrome				29	104					0	0	0	0	A	13839478	A	A	13839478	3	1	121	1	0	0	0	0	1	0	0	0	4626	1174	41	2	8185	2	DNAH5	5	13839478	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	11090853	13839478	167075782	54	21341											
CCDC125	202243	broad.mit.edu	37	chr5	68603840	68603840	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctgcgtatgacttgtggCtttgcccagtattgcctaag	6	14	11	10	1	0	1	0	1	0	0	0	1	0	1	3	1	4	3	3	1	3	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:68603840C>T	uc003jvv.1	-	4	512	c.469G>A	c.(469-471)GCC>ACC	p.A157T	CCDC125_uc003jvx.1_Missense_Mutation_p.A156T|CCDC125_uc003jvy.1_Intron|CCDC125_uc003jvw.2_Missense_Mutation_p.A32T|CCDC125_uc003jvz.1_3'UTR	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	157	Potential.					cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		TGACTTGTGGCTTTGCCCAGT	0.343													49	45					0	0	0	0	T	68603840	T	T	68603840	3	4	121	1	0	0	0	0	1	0	0	0	2773	797	28	4	1098	4	CCDC125	5	68603840	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	54764362	68603840	112311420	55	21342											
NUDT12	83594	broad.mit.edu	37	chr5	102895788	102895788	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctctgggtgcccattcctTgccgcatacattaaagcagt	9	12	8	12	1	1	0	0	0	1	0	3	0	2	0	3	1	4	2	3	1	3	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:102895788T>G	uc003koi.2	-	2	255	c.162A>C	c.(160-162)GCA>GCC	p.A54A	NUDT12_uc011cvb.1_Intron|NUDT12_uc010jbq.1_Silent_p.A54A	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	54	ANK 2.					nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		GCCCATTCCTTGCCGCATACA	0.408													14	106					0	0	0	0	G	102895788	G	G	102895788	2	3	121	1	0	0	0	0	0	0	0	1	10782	1799	63	5		5	NUDT12	5	102895788	Silent	SNP	T	TCGA-CR-6471-01A-11D-1870-08	34291948	102895788	78019472	56	21343											
CXXC5	51523	broad.mit.edu	37	chr5	139060923	139060923	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgcgcgccctgccggcggcGcatcaactgcgagcagtgca	6	5	15	15	6	1	0	1	0	0	0	1	1	1	0	2	2	6	3	2	2	1	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:139060923G>A	uc010jfg.1	+	2	1105	c.815G>A	c.(814-816)CGC>CAC	p.R272H	CXXC5_uc003let.2_Missense_Mutation_p.R272H	NM_016463	NP_057547	Q7LFL8	CXXC5_HUMAN	CXXC finger 5	272	CXXC-type.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCGGCGGCGCATCAACTGC	0.572													81	112					0	0	0	0	A	139060923	A	A	139060923	3	1	121	1	0	0	0	0	1	0	0	0	4116	1087	38	1	817	1	CXXC5	5	139060923	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	36165135	139060923	41854337	57	21344											
PCDHA7	56141	broad.mit.edu	37	chr5	140215783	140215783	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgactcaggctacaacgcGtggctttcgtatgagttgca	8	11	12	10	3	1	2	1	2	0	0	2	2	1	2	0	2	3	6	0	2	3	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:140215783G>T	uc003lhq.2	+	1	1815	c.1815G>T	c.(1813-1815)GCG>GCT	p.A605A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.A605A	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	605	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTACAACGCGTGGCTTTCGT	0.637													31	83					5.60225e-13	6.30653e-13	1	0	T	140215783	T	T	140215783	2	4	121	1	0	0	0	0	0	0	0	1	11583	1132	40	3		3	PCDHA7	5	140215783	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	1154860	140215783	40699477	58	21345											
PCDHA12	56137	broad.mit.edu	37	chr5	140256301	140256301	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggacagcgccctggaccGcgagagcgtgtcggcctatg	6	6	16	13	5	0	1	0	0	0	1	1	4	0	3	3	3	2	1	3	3	1	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:140256301G>A	uc003lic.2	+	1	1371	c.1244G>A	c.(1243-1245)CGC>CAC	p.R415H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.R415H	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	415	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCTGGACCGCGAGAGCGTG	0.612													57	223					0	0	0	0	A	140256301	A	A	140256301	3	1	121	1	0	0	0	0	1	0	0	0	11576	1087	38	1	1246	1	PCDHA12	5	140256301	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	40518	140256301	40658959	59	21346											
PCDHGA9	56107	broad.mit.edu	37	chr5	140783917	140783918	+	Frame_Shift_Del	DEL	CA	-	-																															tacctcccggaaaacaacgcCagaggtacttccatcttctc																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:140783917_140783918delCA	uc003lkh.1	+	1	1398_1399	c.1398_1399delCA	c.(1396-1401)GCCAGAfs	p.A466fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Frame_Shift_Del_p.A466fs	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	466_467	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAACAACGCCAGAGGTACTTC	0.47													---	---	---								-	140783918	-	-	140783917	7	5	121	1	0	1	0	1	0	0	0	0	11615	581	21	0	1400	0	PCDHGA9	5	140783917	Frame_Shift_Del	DEL	CA	TCGA-CR-6471-01A-11D-1870-08	527616	140783917	40131343	60	21347											
SGCD	6444	broad.mit.edu	37	chr5	156186283	156186283	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcctcatggatcctacaCgcctacaggaacgaggcaga	12	6	10	13	2	1	1	1	0	0	1	2	4	2	3	3	3	4	1	3	3	3	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:156186283C>T	uc003lwd.3	+	8	1228	c.752C>T	c.(751-753)ACG>ATG	p.T251M	SGCD_uc003lwc.3_Missense_Mutation_p.T252M	NM_001128209	NP_001121681	Q92629	SGCD_HUMAN	delta-sarcoglycan isoform 3	251	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGATCCTACACGCCTACAGGA	0.498													20	106					0	0	0	0	T	156186283	T	T	156186283	3	4	121	1	0	0	0	0	1	0	0	0	14266	536	19	1	857	1	SGCD	5	156186283	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	15402366	156186283	24728977	61	21348											
STK10	6793	broad.mit.edu	37	chr5	171520586	171520586	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccattggccagcttctcccCacccaaggtctccagggcgc	6	7	10	18	1	2	0	0	0	2	0	4	0	2	0	6	3	1	1	6	3	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:171520586C>T	uc003mbo.1	-	9	1684	c.1384G>A	c.(1384-1386)GGG>AGG	p.G462R		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	462							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGCTTCTCCCCACCCAAGGTC	0.652													23	96					0	0	0	0	T	171520586	T	T	171520586	3	4	121	1	0	0	0	0	1	0	0	0	15352	594	21	4	1566	4	STK10	5	171520586	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	15334303	171520586	9394674	62	21349											
STK10	6793	broad.mit.edu	37	chr5	171534817	171534817	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgaaggaatctcgtttcTgtagagtcttcagattcttg	9	15	10	7	2	5	3	1	1	4	2	6	5	5	4	0	1	0	2	0	1	3	5			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:171534817T>C	uc003mbo.1	-	5	860	c.560A>G	c.(559-561)CAG>CGG	p.Q187R		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	187	Protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATCTCGTTTCTGTAGAGTCTT	0.498											OREG0017039	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	54					0	0	0	0	C	171534817	C	C	171534817	3	2	121	1	0	0	0	0	1	0	0	0	15352	1580	55	5	2406	5	STK10	5	171534817	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08	14231	171534817	9380443	63	21350											
SH3PXD2B	285590	broad.mit.edu	37	chr5	171774317	171774317	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccggcgaggagggggtctCtgcctcatctttggtgatcc	4	11	14	12	2	3	1	1	1	2	0	6	3	5	2	3	5	1	0	3	5	0	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr5:171774317C>T	uc003mbr.2	-	11	1203	c.1032G>A	c.(1030-1032)CAG>CAA	p.Q344Q		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	344					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAGGGGGTCTCTGCCTCATCT	0.542													11	79					0	0	0	0	T	171774317	T	T	171774317	2	4	121	1	0	0	0	0	0	0	0	1	14322	912	32	2		2	SH3PXD2B	5	171774317	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	239500	171774317	9140943	64	21351											
GPX6	257202	broad.mit.edu	37	chr6	28473490	28473490	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actcatgcaccttcaggaaaGtaaagaccttctgttctttt	11	14	6	10	0	4	1	2	0	2	1	4	2	4	2	2	1	1	3	2	1	3	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:28473490G>T	uc011dlj.1	-	5	499	c.449C>A	c.(448-450)ACT>AAT	p.T150N	GPX6_uc010jrg.1_Intron	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	150					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	CTTCAGGAAAGTAAAGACCTT	0.473													15	72					6.31663e-08	6.83723e-08	1	0	T	28473490	T	T	28473490	3	4	121	1	0	0	0	0	1	0	0	0	6783	1029	36	4	224	4	GPX6	6	28473490	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08		28473490	142641577	65	21352											
TAP2	6891	broad.mit.edu	37	chr6	32782192	32782192	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatttctagcatcaccacaGtctgaaaggtccagtctcca	11	11	6	13	0	5	1	2	1	3	0	7	1	6	1	3	1	1	1	3	1	2	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:32782192G>A	uc011dqf.1	-	14	2491	c.2369C>T	c.(2368-2370)ACT>ATT	p.T790I	HLA-DOB_uc003oca.2_Missense_Mutation_p.T183I|HLA-DOB_uc011dqg.1_Missense_Mutation_p.T183I	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	Error:Variant_position_missing_in_Q03519_after_alignment					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						CATCACCACAGTCTGAAAGGT	0.532													33	88					0	0	0	0	A	32782192	A	A	32782192	3	1	121	1	0	0	0	0	1	0	0	0	15617	1029	36	4		4	TAP2	6	32782192	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	4308702	32782192	138332875	66	21353											
GRM4	2914	broad.mit.edu	37	chr6	34029792	34029792	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtatcttcaccgactgggcGatgcacacgccccctgcagg	7	7	12	15	3	2	0	1	0	1	0	2	2	2	0	3	3	2	3	3	3	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:34029792G>T	uc003oir.3	-	3	920	c.750C>A	c.(748-750)ATC>ATA	p.I250I	GRM4_uc011dsn.1_Silent_p.I250I|GRM4_uc010jvh.2_Silent_p.I250I|GRM4_uc010jvi.2_5'UTR|GRM4_uc003oio.2_5'UTR|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Silent_p.I110I|GRM4_uc003oiq.2_Silent_p.I117I|GRM4_uc011dsm.1_Silent_p.I81I	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	250	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	CCGACTGGGCGATGCACACGC	0.627													26	28					1.66031e-10	1.82726e-10	1	0	T	34029792	T	T	34029792	2	4	121	1	0	0	0	0	0	0	0	1	6838	1048	37	3		3	GRM4	6	34029792	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	1247600	34029792	137085275	67	21354											
PAQR8	85315	broad.mit.edu	37	chr6	52268776	52268776	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	accctccagatcctcttcttCctggttagcgcttatttctt	5	17	5	14	1	3	1	0	0	3	1	6	1	6	1	4	1	1	2	4	1	2	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:52268776C>T	uc003pao.3	+	2	939	c.765C>T	c.(763-765)TTC>TTT	p.F255F		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	255	Helical; Name=5; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					TCCTCTTCTTCCTGGTTAGCG	0.577													14	55					0	0	0	0	T	52268776	T	T	52268776	2	4	121	1	0	0	0	0	0	0	0	1	11495	854	30	2		2	PAQR8	6	52268776	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	18238984	52268776	118846291	68	21355											
FAM83B	222584	broad.mit.edu	37	chr6	54735396	54735396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgatgcccggactcttagggGgcacccatatagatctcctt	8	11	10	12	1	2	2	0	1	2	1	3	3	2	3	3	3	1	1	3	3	3	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:54735396G>A	uc003pck.2	+	2	468	c.352G>A	c.(352-354)GGC>AGC	p.G118S		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	118										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					ACTCTTAGGGGGCACCCATAT	0.433													32	93					0	0	0	0	A	54735396	A	A	54735396	3	1	121	1	0	0	0	0	1	0	0	0	5666	1232	43	4	354	4	FAM83B	6	54735396	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	2466620	54735396	116379671	69	21356											
EPHA7	2045	broad.mit.edu	37	chr6	94068069	94068069	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctttatcagaaaaactgtgaGttggacaacgagagcactga	15	9	10	7	1	1	4	1	2	0	2	1	6	1	5	0	1	3	2	0	1	4	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:94068069G>T	uc003poe.2	-	4	1134	c.893C>A	c.(892-894)ACT>AAT	p.T298N	EPHA7_uc003pof.2_Missense_Mutation_p.T298N|EPHA7_uc011eac.1_Missense_Mutation_p.T298N	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	298	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		AAAACTGTGAGTTGGACAACG	0.473													10	66					2.17888e-05	2.2711e-05	1	0	T	94068069	T	T	94068069	3	4	121	1	0	0	0	0	1	0	0	0	5196	1029	36	4	2159	4	EPHA7	6	94068069	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	39332673	94068069	77046998	70	21357											
SIM1	6492	broad.mit.edu	37	chr6	100841635	100841635	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaaactgtctgtaggcgcacGatgcgtcgtgctgggagcca	9	8	14	10	4	1	0	0	0	1	0	2	2	1	1	1	2	4	3	1	2	3	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:100841635G>A	uc003pqj.3	-	10	1505	c.1298C>T	c.(1297-1299)TCG>TTG	p.S433L	SIM1_uc010kcu.2_Missense_Mutation_p.S433L	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	433	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GTAGGCGCACGATGCGTCGTG	0.617													13	59					0	0	0	0	A	100841635	A	A	100841635	3	1	121	1	0	0	0	0	1	0	0	0	14388	1059	37	1	1010	1	SIM1	6	100841635	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	6773566	100841635	70273432	71	21358											
LIN28B	389421	broad.mit.edu	37	chr6	105406144	105406144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccccttggatattccagtcGatgtatttgtacaccaagta	10	13	8	10	1	0	0	0	0	0	0	2	2	1	1	4	1	1	3	4	1	5	7			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:105406144G>A	uc003pqv.1	+	2	384	c.181G>A	c.(181-183)GAT>AAT	p.D61N	LIN28B_uc010kda.1_Missense_Mutation_p.D21N	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	61	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				TATTCCAGTCGATGTATTTGT	0.458													39	114					0	0	0	0	A	105406144	A	A	105406144	3	1	121	1	0	0	0	0	1	0	0	0	8848	1058	37	1	187	1	LIN28B	6	105406144	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	4564509	105406144	65708923	72	21359											
RTN4IP1	84816	broad.mit.edu	37	chr6	107019900	107019900	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attaattacagtctttcctcGtgcgtgtcctctttccacct	6	17	5	13	2	2	0	0	0	2	0	6	0	5	0	4	0	2	0	4	0	2	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:107019900G>A	uc003prj.2	-	9	1639	c.1162C>T	c.(1162-1164)CGA>TGA	p.R388*	RTN4IP1_uc010kdd.2_3'UTR|RTN4IP1_uc003prk.2_Nonsense_Mutation_p.R288*	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	388						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		GTCTTTCCTCGTGCGTGTCCT	0.383													21	94					0	0	0	0	A	107019900	A	A	107019900	4	1	121	1	0	0	0	0	0	1	0	0	13794	1153	40	1	32	1	RTN4IP1	6	107019900	Nonsense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	1613756	107019900	64095167	73	21360											
FAM184A	79632	broad.mit.edu	37	chr6	119341157	119341157	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttaccttctccagttctaGaatctgttgcttctgctctt	5	20	5	11	0	5	1	0	0	5	1	6	1	5	1	2	0	3	4	2	0	3	8			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:119341157G>T	uc003pyj.2	-	4	1666	c.1318C>A	c.(1318-1320)CTA>ATA	p.L440I	FAM184A_uc003pyk.3_Missense_Mutation_p.L320I|FAM184A_uc003pyl.3_Missense_Mutation_p.L320I	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	440	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TCCAGTTCTAGAATCTGTTGC	0.388													25	58					3.65163e-15	4.13431e-15	1	0	T	119341157	T	T	119341157	3	4	121	1	0	0	0	0	1	0	0	0	5539	933	33	2	2164	2	FAM184A	6	119341157	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	12321257	119341157	51773910	74	21361											
C6orf170	221322	broad.mit.edu	37	chr6	121600349	121600349	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaattcttgccaaaatacCagctatatgaattaaagctg	15	12	6	8	0	1	1	0	1	1	0	1	1	1	1	2	0	5	3	2	0	9	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:121600349C>A	uc003pyo.1	-	15	1719	c.1651G>T	c.(1651-1653)GGT>TGT	p.G551C	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_Missense_Mutation_p.G70C	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	551					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		GCCAAAATACCAGCTATATGA	0.323													18	72					1.02788e-11	1.14403e-11	1	0	A	121600349	A	A	121600349	3	1	121	1	0	0	0	0	1	0	0	0	2354	594	21	4	2194	4	C6orf170	6	121600349	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	2259192	121600349	49514718	75	21362											
PBOV1	59351	broad.mit.edu	37	chr6	138539373	138539373	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttactttttctttttttcGaaataccttgtagcagaatg	9	21	5	6	1	1	1	0	0	1	1	2	2	1	1	1	0	3	2	1	0	5	10			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr6:138539373G>A	uc003qhv.2	-	1	255	c.160C>T	c.(160-162)CGA>TGA	p.R54*	KIAA1244_uc003qhu.2_Intron	NM_021635	NP_067648	Q9GZY1	PBOV1_HUMAN	prostate and breast cancer overexpressed 1	54						cytoplasm|nucleus					0	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00055)|GBM - Glioblastoma multiforme(68;0.000674)		TCTTTTTTTCGAAATACCTtg	0.194													10	33					0	0	0	0	A	138539373	A	A	138539373	4	1	121	1	0	0	0	0	0	1	0	0	11544	1066	37	1	251	1	PBOV1	6	138539373	Nonsense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	16939024	138539373	32575694	76	21363											
CARD11	84433	broad.mit.edu	37	chr7	2946386	2946386	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgtcaggttccaccgtggcGtacaggcacggcagggcctc	7	7	14	13	3	1	0	1	0	0	0	3	0	2	0	3	5	1	4	3	5	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr7:2946386G>A	uc003smv.2	-	25	3755	c.3351C>T	c.(3349-3351)TAC>TAT	p.Y1117Y		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	1117	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CCACCGTGGCGTACAGGCACG	0.647			Mis		DLBCL								9	30					0	0	0	0	A	2946386	A	A	2946386	2	1	121	1	0	0	0	0	0	0	0	1	2657	1140	40	1		1	CARD11	7	2946386	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08		2946386	156192277	77	21364											
GCK	2645	broad.mit.edu	37	chr7	44187277	44187277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accggggtttgcagagctctCgtccaccaggcggtcatact	7	9	12	13	3	2	1	1	0	1	1	4	1	3	1	3	4	3	3	3	4	1	2	rs104894005	byFrequency	TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr7:44187277C>T	uc003tkl.2	-	7	1305	c.835G>A	c.(835-837)GAG>AAG	p.E279K	GCK_uc003tkh.1_5'Flank|GCK_uc003tki.1_5'Flank|GCK_uc003tkj.1_Missense_Mutation_p.E278K|GCK_uc003tkk.1_Missense_Mutation_p.E280K	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	279			E -> Q (in MODY2).		cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						GCAGAGCTCTCGTCCACCAGG	0.692													23	62					0	0	0	0	T	44187277	T	T	44187277	3	4	121	1	0	0	0	0	1	0	0	0	6328	893	31	1	578	1	GCK	7	44187277	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	41240891	44187277	114951386	78	21365											
PPP1R9A	55607	broad.mit.edu	37	chr7	94897863	94897863	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatctttcaatattcttagaCttgaatgaagcagtcccaga	13	14	6	8	0	3	4	1	2	2	2	4	4	4	4	1	0	1	1	1	0	6	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr7:94897863C>A	uc003unp.2	+	12	2883	c.2601C>A	c.(2599-2601)GAC>GAA	p.D867E	PPP1R9A_uc010lfj.2_Missense_Mutation_p.D889E|PPP1R9A_uc011kif.1_Missense_Mutation_p.D867E|PPP1R9A_uc003unq.2_Missense_Mutation_p.D867E|PPP1R9A_uc011kig.1_Missense_Mutation_p.D867E|PPP1R9A_uc003unr.2_5'UTR	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	867	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TATTCTTAGACTTGAATGAAG	0.443										HNSCC(28;0.073)			25	48					1.42536e-11	1.5775e-11	1	0	A	94897863	A	A	94897863	3	1	121	1	0	0	0	0	1	0	0	0	12438	579	20	4	2713	4	PPP1R9A	7	94897863	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	50710586	94897863	64240800	79	21366											
RELN	5649	broad.mit.edu	37	chr7	103270590	103270590	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgaactgaattccaaactgCtttgcatcacctggtagttc	10	13	7	11	0	1	2	1	2	0	0	3	2	2	2	2	1	4	4	2	1	4	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr7:103270590C>T	uc003vca.2	-	20	2659	c.2499G>A	c.(2497-2499)AAG>AAA	p.K833K	RELN_uc010liz.2_Silent_p.K833K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	833					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCCAAACTGCTTTGCATCAC	0.343													16	80					0	0	0	0	T	103270590	T	T	103270590	2	4	121	1	0	0	0	0	0	0	0	1	13285	796	28	4		4	RELN	7	103270590	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	8372727	103270590	55868073	80	21367											
PUS7	54517	broad.mit.edu	37	chr7	105099648	105099648	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtggtgtcttcccttctaGgttgtccacatctgtgttga	4	17	11	9	0	3	1	0	1	3	0	5	1	5	1	2	3	0	2	2	3	1	5			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr7:105099648G>A	uc003vcx.2	-	15	2035	c.1816C>T	c.(1816-1818)CTA>TTA	p.L606L	PUS7_uc010lji.2_Silent_p.L612L|PUS7_uc003vcy.2_Silent_p.L606L|PUS7_uc003vcz.1_Silent_p.L606L	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	606					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						TTCCCTTCTAGGTTGTCCACA	0.348													14	41					0	0	0	0	A	105099648	A	A	105099648	2	1	121	1	0	0	0	0	0	0	0	1	12898	991	35	4		4	PUS7	7	105099648	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	1829058	105099648	54039015	81	21368											
CADPS2	93664	broad.mit.edu	37	chr7	122111562	122111562	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtgacagcctctcacacCataacgggcacagtactcat	11	9	7	14	1	3	1	2	1	2	0	4	1	3	1	2	1	3	2	2	1	2	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr7:122111562C>T	uc010lkp.2	-	13	2216	c.2053G>A	c.(2053-2055)GGT>AGT	p.G685S	CADPS2_uc011knx.1_Missense_Mutation_p.G56S|CADPS2_uc003vkg.3_Missense_Mutation_p.G382S|CADPS2_uc010lkq.2_Missense_Mutation_p.G682S	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	685					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						CCTCTCACACCATAACGGGCA	0.418													3	10					0	0	0	0	T	122111562	T	T	122111562	3	4	121	1	0	0	0	0	1	0	0	0	2583	594	21	4	1949	4	CADPS2	7	122111562	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	17011914	122111562	37027101	82	21369											
IMPDH1	3614	broad.mit.edu	37	chr7	128038619	128038619	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcttcttcaggtcggtgcggGcgatgatggccaccagctca	6	10	13	12	3	4	1	2	1	2	0	5	2	4	1	2	4	2	1	2	4	0	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr7:128038619G>T	uc011kol.1	-	7	774	c.668C>A	c.(667-669)GCC>GAC	p.A223D	IMPDH1_uc011kom.1_Missense_Mutation_p.A218D|IMPDH1_uc003vmt.2_Missense_Mutation_p.A198D|IMPDH1_uc003vmu.2_Missense_Mutation_p.A308D|IMPDH1_uc003vmw.2_Missense_Mutation_p.A298D|IMPDH1_uc011kon.1_Missense_Mutation_p.A275D|IMPDH1_uc003vmv.2_Missense_Mutation_p.A272D|IMPDH1_uc003vmx.2_Missense_Mutation_p.A231D|IMPDH1_uc003vmy.2_Missense_Mutation_p.A239D	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	223	CBS 2.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	GTCGGTGCGGGCGATGATGGC	0.577											OREG0018292	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	111					1.06647e-15	1.21442e-15	1	0	T	128038619	T	T	128038619	3	4	121	1	0	0	0	0	1	0	0	0	7765	1203	42	4	908	4	IMPDH1	7	128038619	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	5927057	128038619	31100044	83	21370											
CCDC136	64753	broad.mit.edu	37	chr7	128454860	128454861	+	Frame_Shift_Ins	INS	-	C	C																															gccttctgttgtcaaagaagINScccgggggaagaatgctaat																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr7:128454860_128454861insC	uc003vnv.1	+	15	3299_3300	c.2932_2933insC	c.(2932-2934)GCCfs	p.A978fs	CCDC136_uc003vnu.1_Intron|CCDC136_uc003vnw.1_Intron|CCDC136_uc003vnx.1_Frame_Shift_Ins_p.A794fs|CCDC136_uc010llq.1_Frame_Shift_Ins_p.A347fs|CCDC136_uc003vny.1_Intron	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	978						integral to membrane	protein binding			ovary(2)	2						TGTCAAAGAAGCCCGGGGGAAG	0.54													---	---	---								C	128454861	C	C	128454860	7	5	121	1	0	1	1	0	0	0	0	0	2782	971	34	0	2990	0	CCDC136	7	128454860	Frame_Shift_Ins	INS	-	TCGA-CR-6471-01A-11D-1870-08	416241	128454860	30683803	84	21371											
CSMD1	64478	broad.mit.edu	37	chr8	2966226	2966226	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccgtttcgagggctgtgttgCcactgaaaactcccagctgg	7	10	12	12	2	0	1	0	1	0	0	2	2	1	1	3	2	3	4	3	2	2	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr8:2966226C>T	uc011kwk.1	-	44	7046	c.6656G>A	c.(6655-6657)GGC>GAC	p.G2219D	CSMD1_uc011kwj.1_Missense_Mutation_p.G1611D|CSMD1_uc010lrg.2_Missense_Mutation_p.G287D	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2219	Extracellular (Potential).|CUB 13.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGCTGTGTTGCCACTGAAAAC	0.498													5	12					0	0	0	0	T	2966226	T	T	2966226	3	4	121	1	0	0	0	0	1	0	0	0	3961	739	26	4	4149	4	CSMD1	8	2966226	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08		2966226	143397796	85	21372											
MFHAS1	9258	broad.mit.edu	37	chr8	8749414	8749414	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgtaggggatccccttcatGcagacctcgtaggggggctg	7	9	15	10	1	1	1	1	0	0	1	3	2	2	2	3	5	1	4	3	5	2	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr8:8749414G>A	uc003wsj.1	-	1	1718	c.1155C>T	c.(1153-1155)TGC>TGT	p.C385C		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	385											0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		TCCCCTTCATGCAGACCTCGT	0.617													22	19					0	0	0	0	A	8749414	A	A	8749414	2	1	121	1	0	0	0	0	0	0	0	1	9574	1311	46	4		4	MFHAS1	8	8749414	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	5783188	8749414	137614608	86	21373											
UBR5	51366	broad.mit.edu	37	chr8	103281237	103281237	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aataatgagttccatggcctCatccactcttgctctcagag	10	12	7	12	0	3	2	2	1	2	1	6	2	5	2	3	1	1	2	3	1	2	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr8:103281237C>A	uc003ykr.1	-	51	7363	c.7330G>T	c.(7330-7332)GAG>TAG	p.E2444*	UBR5_uc003yks.1_Nonsense_Mutation_p.E2444*|UBR5_uc003ykq.2_5'Flank	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2444	PABC.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TCCATGGCCTCATCCACTCTT	0.443													27	117					3.73148e-12	4.17671e-12	1	0	A	103281237	A	A	103281237	4	1	121	1	0	0	0	0	0	1	0	0	16973	835	29	2	1105	2	UBR5	8	103281237	Nonsense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	94531823	103281237	43082785	87	21374											
ZNF572	137209	broad.mit.edu	37	chr8	125989237	125989237	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gatcacatacaggtgaaaaaCcatatgaatgttctgtctgc	14	11	8	8	0	3	2	1	2	2	0	3	3	3	2	1	1	3	1	1	1	5	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr8:125989237C>A	uc003yrr.2	+	3	882	c.727C>A	c.(727-729)CCA>ACA	p.P243T		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AGGTGAAAAACCATATGAATG	0.453										HNSCC(60;0.17)			22	90					1.26454e-06	1.34657e-06	1	0	A	125989237	A	A	125989237	3	1	121	1	0	0	0	0	1	0	0	0	18071	507	18	4	733	4	ZNF572	8	125989237	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	22708000	125989237	20374785	88	21375											
ASAP1	50807	broad.mit.edu	37	chr8	131130412	131130412	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaacaaaaacgataccagttTtgtacaaggaagtcaaccaa	20	7	6	8	1	1	0	1	0	0	0	1	2	1	1	2	1	5	2	2	1	9	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr8:131130412T>G	uc003yta.1	-	19	1903	c.1875A>C	c.(1873-1875)CAA>CAC	p.Q625H	ASAP1_uc003ysz.1_Missense_Mutation_p.Q436H|ASAP1_uc011liw.1_Missense_Mutation_p.Q618H	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	625	ANK 1.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						GATACCAGTTTTGTACAAGGA	0.388													34	42					0	0	0	0	G	131130412	G	G	131130412	3	3	121	1	0	0	0	0	1	0	0	0	1012	1838	64	5	1558	5	ASAP1	8	131130412	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08	5141175	131130412	15233610	89	21376											
GPAA1	8733	broad.mit.edu	37	chr8	145139718	145139718	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccccggcctctcccgcttCgtctccatcggcctctacat	3	11	6	21	4	3	0	0	0	3	0	8	0	4	0	6	2	1	1	6	2	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr8:145139718C>T	uc003zax.2	+	8	1214	c.1104C>T	c.(1102-1104)TTC>TTT	p.F368F	GPAA1_uc003zav.1_Silent_p.F246F|GPAA1_uc003zaw.1_Silent_p.F308F	NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	368	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCTCCCGCTTCGTCTCCATCG	0.607													83	93					0	0	0	0	T	145139718	T	T	145139718	2	4	121	1	0	0	0	0	0	0	0	1	6625	883	31	1		1	GPAA1	8	145139718	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	14009306	145139718	1224304	90	21377											
IFNA21	3452	broad.mit.edu	37	chr9	21166295	21166295	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagttcagtggaaaattttTctaggaggctctgttcccaa	11	14	9	7	0	3	0	1	0	2	0	4	2	4	2	1	3	0	3	1	3	5	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr9:21166295T>G	uc003zom.2	-	1	365	c.317A>C	c.(316-318)GAA>GCA	p.E106A		NM_002175	NP_002166	P01568	IFN21_HUMAN	interferon, alpha 21 precursor	106					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GGAAAATTTTTCTAGGAGGCT	0.498													45	178					0	0	0	0	G	21166295	G	G	21166295	3	3	121	1	0	0	0	0	1	0	0	0	7577	1783	62	5	256	5	IFNA21	9	21166295	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08		21166295	120047136	91	21378											
GOLGA1	2800	broad.mit.edu	37	chr9	127650555	127650556	+	Nonsense_Mutation	DNP	GC	AA	AA																															atttttctccagaagttgctGctccaagtcctgtttctcct																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr9:127650555_127650556GC>AA	uc004bpc.2	-	19	2223_2224	c.1881_1882GC>TT	c.(1879-1884)GAGCAG>GATTAG	p.627_628EQ>D*	GOLGA1_uc010mws.2_RNA	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	627_628	Potential.					Golgi cisterna membrane				ovary(1)	1						AGAAGTTGCTGCTCCAAGTCCT	0.515													42	251					0	0	0	0	AA	127650556	AA	AA	127650555	4	1	121	1	0	0	0	0	0	1	0	0	6588	1328	46	4	441	4	GOLGA1	9	127650555	Nonsense_Mutation	DNP	GC	TCGA-CR-6471-01A-11D-1870-08	106484260	127650555	13562876	92	21379											
MRC1	4360	broad.mit.edu	37	chr10	17875801	17875801	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacagaacgctgagctcctGagcatcacagagattcatga	14	7	9	11	1	2	5	2	3	0	2	3	6	3	5	1	0	4	3	1	0	2	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr10:17875801G>A	uc001ipk.2	+	4	868	c.765G>A	c.(763-765)CTG>CTA	p.L255L		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	255	C-type lectin 1.|Extracellular (Potential).				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						CTGAGCTCCTGAGCATCACAG	0.428													34	43					0	0	0	0	A	17875801	A	A	17875801	2	1	121	1	0	0	0	0	0	0	0	1	9809	1277	45	2		2	MRC1	10	17875801	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08		17875801	117658946	93	21380											
TMEM72	643236	broad.mit.edu	37	chr10	45430152	45430152	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacttccttctgagcaagcGgaagaagaggaaagctgccc	12	7	11	11	1	1	3	0	1	1	2	2	5	2	5	2	2	5	2	2	2	5	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr10:45430152G>A	uc001jbn.2	+	5	595	c.398G>A	c.(397-399)CGG>CAG	p.R133Q	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Missense_Mutation_p.R15Q	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	133						integral to membrane					0						CTGAGCAAGCGGAAGAAGAGG	0.602													25	79					0	0	0	0	A	45430152	A	A	45430152	3	1	121	1	0	0	0	0	1	0	0	0	16267	1116	39	1	416	1	TMEM72	10	45430152	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	27554351	45430152	90104595	94	21381											
CHAT	1103	broad.mit.edu	37	chr10	50833611	50833611	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcttctcctcctaccggcTccccggccatacccaggaca	6	8	7	20	2	2	0	0	0	2	0	5	1	4	1	7	3	2	2	7	3	2	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr10:50833611T>C	uc001jhz.2	+	6	998	c.845T>C	c.(844-846)CTC>CCC	p.L282P	CHAT_uc001jhv.1_Missense_Mutation_p.L164P|CHAT_uc001jhx.1_Missense_Mutation_p.L164P|CHAT_uc001jhy.1_Missense_Mutation_p.L164P|CHAT_uc001jia.2_Missense_Mutation_p.L164P|CHAT_uc010qgs.1_Missense_Mutation_p.L164P	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	282					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TCCTACCGGCTCCCCGGCCAT	0.592													10	7					0	0	0	0	C	50833611	C	C	50833611	3	2	121	1	0	0	0	0	1	0	0	0	3328	1551	54	5	911	5	CHAT	10	50833611	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08	5403459	50833611	84701136	95	21382											
ASAH2B	653308	broad.mit.edu	37	chr10	52502706	52502706	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaggcagcatcgacaatttAtggaccgcacgcattatctg	11	10	10	10	3	1	1	0	1	1	0	2	3	1	2	1	2	1	4	1	2	3	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr10:52502706A>G	uc001jjg.2	+	2	87	c.22A>G	c.(22-24)ATG>GTG	p.M8V	ASAH2B_uc010qhm.1_5'UTR	NM_001079516	NP_001072984	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal	Error:Variant_position_missing_in_Q9NR71_after_alignment					apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						TCGACAATTTATGGACCGCAC	0.373													58	176					0	0	0	0	G	52502706	G	G	52502706	3	3	121	1	0	0	0	0	1	0	0	0	1010	449	16	5	24	5	ASAH2B	10	52502706	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	1669095	52502706	83032041	96	21383											
SH2D4B	387694	broad.mit.edu	37	chr10	82403807	82403807	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaccctgcggacagagggAcagcccaccagactaccatc	12	3	11	15	1	0	2	0	0	0	2	1	5	0	5	4	3	4	0	4	3	2	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr10:82403807A>C	uc001kck.1	+	7	1474	c.1044A>C	c.(1042-1044)GGA>GGC	p.G348G	SH2D4B_uc001kcl.1_Silent_p.G300G|SH2D4B_uc001kcm.1_Missense_Mutation_p.D169A|SH2D4B_uc001kcn.1_RNA	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	Error:Variant_position_missing_in_Q5SQS7_after_alignment											0			Colorectal(32;0.229)			GGACAGAGGGACAGCCCACCA	0.373													9	36					0	0	0	0	C	82403807	C	C	82403807	2	2	121	1	0	0	0	0	0	0	0	1	14301	262	10	5		5	SH2D4B	10	82403807	Silent	SNP	A	TCGA-CR-6471-01A-11D-1870-08	29901101	82403807	53130940	97	21384											
CNNM2	54805	broad.mit.edu	37	chr10	104835934	104835934	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacgccgtcacaccaacactGgggagcagcaataaccagct	13	4	10	14	2	1	0	1	0	0	0	1	2	1	1	3	2	5	3	3	2	3	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr10:104835934G>A	uc001kwm.2	+	7	2449	c.2325G>A	c.(2323-2325)CTG>CTA	p.L775L	CNNM2_uc001kwn.2_Silent_p.L753L	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	775					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CACCAACACTGGGGAGCAGCA	0.527													3	12					0	0	0	0	A	104835934	A	A	104835934	2	1	121	1	0	0	0	0	0	0	0	1	3628	1335	47	4		4	CNNM2	10	104835934	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	22432127	104835934	30698813	98	21385											
DOCK1	1793	broad.mit.edu	37	chr10	129216755	129216755	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccgctctccatgctcctgAacggcatcgtggacccagct	7	8	9	17	3	1	1	0	1	1	0	4	2	2	2	4	2	3	4	4	2	1	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr10:129216755A>T	uc001ljt.2	+	45	4643	c.4579A>T	c.(4579-4581)AAC>TAC	p.N1527Y	DOCK1_uc010qun.1_Missense_Mutation_p.N1548Y|DOCK1_uc009yaq.2_Missense_Mutation_p.N522Y	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1527	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CATGCTCCTGAACGGCATCGT	0.602													7	26					0	0	0	0	T	129216755	T	T	129216755	3	4	121	1	0	0	0	0	1	0	0	0	4706	246	9	5	4757	5	DOCK1	10	129216755	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	24380821	129216755	6317992	99	21386											
KRTAP5-3	387266	broad.mit.edu	37	chr11	1629441	1629441	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccttggagcccccacaggAgccacagctggagcaggaac	10	3	12	16	0	0	0	0	0	0	0	0	4	0	4	5	4	5	2	5	4	1	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr11:1629441A>G	uc001ltw.1	-	1	253	c.175T>C	c.(175-177)TCC>CCC	p.S59P		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	59	11 X 4 AA repeats of C-C-X-P.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		CCCCCACAGGAGCCACAGCTG	0.677													72	193					0	0	0	0	G	1629441	G	G	1629441	3	3	121	1	0	0	0	0	1	0	0	0	8602	304	11	5	545	5	KRTAP5-3	11	1629441	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08		1629441	133377075	100	21387											
DCHS1	8642	broad.mit.edu	37	chr11	6653621	6653621	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaggccaaaggggctacttGctccctctgctgcaaggtga	8	8	12	13	0	1	1	0	1	1	0	2	1	2	1	3	4	4	4	3	4	3	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr11:6653621G>T	uc001mem.1	-	6	3532	c.3122C>A	c.(3121-3123)GCA>GAA	p.A1041E		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1041	Cadherin 10.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGGCTACTTGCTCCCTCTGC	0.597													15	38					2.23348e-06	2.35292e-06	1	0	T	6653621	T	T	6653621	3	4	121	1	0	0	0	0	1	0	0	0	4304	1319	46	4	6838	4	DCHS1	11	6653621	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	5024180	6653621	128352895	101	21388											
SLC15A3	51296	broad.mit.edu	37	chr11	60709581	60709581	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggaaaatgtttgggatgtGgaggtgaagaccctgcagga	11	9	17	4	0	0	2	0	1	0	1	0	6	0	6	1	5	1	2	1	5	3	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr11:60709581G>C	uc001nqn.2	-	4	1267	c.1033C>G	c.(1033-1035)CAC>GAC	p.H345D	SLC15A3_uc001nqo.2_Missense_Mutation_p.H345D	NM_016582	NP_057666	Q8IY34	S15A3_HUMAN	solute carrier family 15, member 3	345					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0						TTTGGGATGTGGAGGTGAAGA	0.577													33	111					0	0	0	0	C	60709581	C	C	60709581	3	2	121	1	0	0	0	0	1	0	0	0	14465	1348	47	4	732	4	SLC15A3	11	60709581	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	54055960	60709581	74296935	102	21389											
SLC6A13	6540	broad.mit.edu	37	chr12	330578	330578	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgagggttccgagtctgtaGaggctccaggcaggaatgca	9	9	15	8	1	1	2	0	1	1	1	3	4	3	3	2	4	1	5	2	4	2	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr12:330578G>A	uc001qic.1	-	14	1703	c.1650C>T	c.(1648-1650)CTC>CTT	p.L550L	SLC6A13_uc009zdj.1_Silent_p.L540L|SLC6A13_uc010sdl.1_Silent_p.L458L	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	550	Cytoplasmic (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CGAGTCTGTAGAGGCTCCAGG	0.632													8	15					0	0	0	0	A	330578	A	A	330578	2	1	121	1	0	0	0	0	0	0	0	1	14740	929	33	2		2	SLC6A13	12	330578	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08		330578	133521317	103	21390											
TAS2R7	50837	broad.mit.edu	37	chr12	10954990	10954990	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaacaatctaatagtattacGcacaatagacaaattctgga	19	10	5	7	1	2	1	0	0	2	1	2	2	2	2	0	1	2	2	0	1	9	6	rs141765045		TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr12:10954990G>A	uc001qyv.2	-	1	237	c.180C>T	c.(178-180)TGC>TGT	p.C60C		NM_023919	NP_076408	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	60	Helical; Name=2; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						ATAGTATTACGCACAATAGAC	0.378													26	64					0	0	0	0	A	10954990	A	A	10954990	2	1	121	1	0	0	0	0	0	0	0	1	15652	1079	38	1		1	TAS2R7	12	10954990	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	10624412	10954990	122896905	104	21391											
CEP290	80184	broad.mit.edu	37	chr12	88480186	88480186	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accttttgtgccgcatttagTatttcattttgctgacggtc	6	18	8	9	2	1	1	1	1	0	0	2	1	1	1	2	1	2	3	2	1	2	8			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr12:88480186T>C	uc001tar.2	-	33	4628	c.4284A>G	c.(4282-4284)ATA>ATG	p.I1428M	CEP290_uc001taq.2_Missense_Mutation_p.I488M	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1428	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						CCGCATTTAGTATTTCATTTT	0.363													5	17					0	0	0	0	C	88480186	C	C	88480186	3	2	121	1	0	0	0	0	1	0	0	0	3268	1628	57	5	3243	5	CEP290	12	88480186	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08	77525196	88480186	45371709	105	21392											
UTP20	27340	broad.mit.edu	37	chr12	101748816	101748816	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcctcaaaacaaggaagaaAtagagagaacaattaaaaat	23	7	6	5	0	1	3	1	0	0	3	2	5	2	4	1	1	2	0	1	1	11	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr12:101748816A>G	uc001tia.1	+	41	5470	c.5314A>G	c.(5314-5316)ATA>GTA	p.I1772V		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1772					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						CAAGGAAGAAATAGAGAGAAC	0.433													8	47					0	0	0	0	G	101748816	G	G	101748816	3	3	121	1	0	0	0	0	1	0	0	0	17167	101	4	5	5476	5	UTP20	12	101748816	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	13268630	101748816	32103079	106	21393											
GNPTAB	79158	broad.mit.edu	37	chr12	102153816	102153816	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cattccacttaccaggttggGatcatagtaggattcctgag	10	12	10	9	0	1	1	1	1	0	0	3	3	3	3	3	3	1	2	3	3	3	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr12:102153816G>A	uc001tit.2	-	16	3420	c.3241C>T	c.(3241-3243)CCC>TCC	p.P1081S		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	1081					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						ACCAGGTTGGGATCATAGTAG	0.388													15	47					0	0	0	0	A	102153816	A	A	102153816	3	1	121	1	0	0	0	0	1	0	0	0	6582	1174	41	2	553	2	GNPTAB	12	102153816	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	405000	102153816	31698079	107	21394											
TRPV4	59341	broad.mit.edu	37	chr12	110240837	110240837	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcgagttaatgaactccCtcatgttgccggtgcgctcc	7	10	12	12	3	1	1	1	1	0	0	3	2	3	1	3	2	3	3	3	2	2	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr12:110240837C>A	uc001tpj.1	-	3	766	c.671G>T	c.(670-672)AGG>ATG	p.R224M	TRPV4_uc001tpg.1_Missense_Mutation_p.R190M|TRPV4_uc001tph.1_Missense_Mutation_p.R224M|TRPV4_uc001tpi.1_Missense_Mutation_p.R224M|TRPV4_uc001tpk.1_Missense_Mutation_p.R224L|TRPV4_uc001tpl.1_Missense_Mutation_p.R224L	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	224	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AATGAACTCCCTCATGTTGCC	0.632													15	29					4.7546e-09	5.1749e-09	1	0	A	110240837	A	A	110240837	3	1	121	1	0	0	0	0	1	0	0	0	16665	681	24	4	1996	4	TRPV4	12	110240837	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	8087021	110240837	23611058	108	21395											
SPPL3	121665	broad.mit.edu	37	chr12	121206162	121206162	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttttccaggcagagacaggcGaggaacatcacgcccaacat	13	6	10	12	2	1	1	1	0	0	1	2	4	2	2	2	3	2	1	2	3	2	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr12:121206162G>C	uc001tzd.2	-	8	1220	c.739C>G	c.(739-741)CGC>GGC	p.R247G	SPPL3_uc009zwz.2_Missense_Mutation_p.R240G|SPPL3_uc001tzc.2_Missense_Mutation_p.R77G	NM_139015	NP_620584	Q8TCT6	PSL4_HUMAN	signal peptide peptidase 3	248						integral to membrane	aspartic-type endopeptidase activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGAGACAGGCGAGGAACATCA	0.562													26	99					0	0	0	0	C	121206162	C	C	121206162	3	2	121	1	0	0	0	0	1	0	0	0	15156	1058	37	3	431	3	SPPL3	12	121206162	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	10965325	121206162	12645733	109	21396											
CAMKK2	10645	broad.mit.edu	37	chr12	121682412	121682412	+	Frame_Shift_Del	DEL	T	-	-																															gactcacattccctggttggTtttttgctggaatcaccaga																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr12:121682412delT	uc001tzu.2	-	16	1684	c.1560delA	c.(1558-1560)AAAfs	p.K520fs	CAMKK2_uc001tzt.2_Intron|CAMKK2_uc001tzv.2_Frame_Shift_Del_p.K520fs|CAMKK2_uc001tzw.2_Frame_Shift_Del_p.K477fs|CAMKK2_uc001tzx.2_Intron|CAMKK2_uc001tzy.2_Intron|CAMKK2_uc001tzz.1_Frame_Shift_Del_p.K307fs|CAMKK2_uc001uaa.1_Frame_Shift_Del_p.K520fs|CAMKK2_uc001uab.2_Frame_Shift_Del_p.K520fs|CAMKK2_uc001uac.2_Frame_Shift_Del_p.K477fs	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase	520					calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCCTGGTTGGTTTTTTGCTGG	0.627													---	---	---								-	121682412	-	-	121682412	7	5	121	1	0	1	0	1	0	0	0	0	2619	1722	60	0	224	0	CAMKK2	12	121682412	Frame_Shift_Del	DEL	T	TCGA-CR-6471-01A-11D-1870-08	476250	121682412	12169483	110	21397											
WASF3	10810	broad.mit.edu	37	chr13	27257005	27257005	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcccgggtcttctctttcGtcctccccaatgcatggccc	3	12	9	17	2	2	0	0	0	2	0	7	0	5	0	5	3	1	1	5	3	1	2	rs148684191		TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr13:27257005G>A	uc001uqv.2	+	9	1470	c.1245G>A	c.(1243-1245)TCG>TCA	p.S415S	WASF3_uc001uqw.2_Silent_p.S412S	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	415					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CTTCTCTTTCGTCCTCCCCAA	0.677													27	91					0	0	0	0	A	27257005	A	A	27257005	2	1	121	1	0	0	0	0	0	0	0	1	17322	1132	40	1		1	WASF3	13	27257005	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08		27257005	87912873	111	21398											
DOCK9	23348	broad.mit.edu	37	chr13	99476709	99476709	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatggaggcctcctcgtcGatgtttggggtaatgaccct	7	12	12	10	2	1	1	1	1	0	0	4	3	2	2	3	4	0	2	3	4	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr13:99476709G>T	uc001vnt.2	-	46	5131	c.5076C>A	c.(5074-5076)ATC>ATA	p.I1692I	DOCK9_uc001vnw.2_Silent_p.I1691I|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.I1669I|DOCK9_uc001vnq.2_Silent_p.I241I|DOCK9_uc001vnr.2_Silent_p.I335I|DOCK9_uc010tin.1_Silent_p.I312I|DOCK9_uc001vns.2_Silent_p.I241I|DOCK9_uc010tio.1_Silent_p.I361I|DOCK9_uc010tip.1_Silent_p.I402I|DOCK9_uc001vnu.1_Silent_p.I241I|DOCK9_uc010tiq.1_Silent_p.I647I	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1692	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCTCCTCGTCGATGTTTGGGG	0.537													32	111					1.36161e-19	1.56864e-19	1	0	T	99476709	T	T	99476709	2	4	121	1	0	0	0	0	0	0	0	1	4716	1048	37	3		3	DOCK9	13	99476709	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	72219704	99476709	15693169	112	21399											
C13orf39	196541	broad.mit.edu	37	chr13	103343240	103343240	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcctgcaaaccgataatgctCctgagtgtagctggcgtaat	10	11	10	10	2	0	1	0	1	0	0	2	2	2	1	3	1	4	5	3	1	4	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr13:103343240C>T	uc001vpj.2	-	2	211	c.205G>A	c.(205-207)GAG>AAG	p.E69K	C13orf39_uc001vpk.2_Missense_Mutation_p.E69K	NM_001010977	NP_001010977	Q5VZV1	MT21C_HUMAN	hypothetical protein LOC196541	69							methyltransferase activity				0						CGATAATGCTCCTGAGTGTAG	0.448													25	56					0	0	0	0	T	103343240	T	T	103343240	3	4	121	1	0	0	0	0	1	0	0	0	1738	864	30	2	601	2	C13orf39	13	103343240	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	3866531	103343240	11826638	113	21400											
MYH6	4624	broad.mit.edu	37	chr14	23862217	23862217	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctccagtttccgctttgctCgctccaggtccatgcgcacc	4	11	8	18	3	0	0	0	0	0	0	5	0	4	0	6	1	2	5	6	1	0	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr14:23862217C>T	uc001wjv.2	-	24	3222	c.3155G>A	c.(3154-3156)CGA>CAA	p.R1052Q		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1052	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCGCTTTGCTCGCTCCAGGTC	0.488													31	73					0	0	0	0	T	23862217	T	T	23862217	3	4	121	1	0	0	0	0	1	0	0	0	10091	884	31	1	2728	1	MYH6	14	23862217	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08		23862217	83487323	114	21401											
RTF1	23168	broad.mit.edu	37	chr15	41750014	41750014	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtctggaacagatgacagAgaaagagagagagcaagaac	18	3	13	7	1	1	6	0	1	1	5	1	10	1	7	1	1	3	1	1	1	4	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr15:41750014A>G	uc001zny.2	+	4	614	c.602A>G	c.(601-603)GAG>GGG	p.E201G		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	201	Glu-rich.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		CAGATGACAGAGAAAGAGAGA	0.517													27	71					0	0	0	0	G	41750014	G	G	41750014	3	3	121	1	0	0	0	0	1	0	0	0	13786	304	11	5	616	5	RTF1	15	41750014	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08		41750014	60781378	115	21402											
RFX7	64864	broad.mit.edu	37	chr15	56387585	56387586	+	Frame_Shift_Ins	INS	-	A	A																															ttagtgatttgttgccatccINSatttggattaaagctgccaa																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr15:56387585_56387586insA	uc010bfn.2	-	9	2340_2341	c.2340_2341insT	c.(2338-2343)AATGGAfs	p.N780fs	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Frame_Shift_Ins_p.N594fs	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	683_684					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						TGTTGCCATCCATTTGGATTAA	0.371													---	---	---								A	56387586	A	A	56387585	7	5	121	1	0	1	1	0	0	0	0	0	13333	603	21	0	2045	0	RFX7	15	56387585	Frame_Shift_Ins	INS	-	TCGA-CR-6471-01A-11D-1870-08	14637571	56387585	46143807	116	21403											
IGDCC3	9543	broad.mit.edu	37	chr15	65621833	65621833	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcccagctggccccgctgTccccgtctcgccccatttag	3	8	10	20	4	1	0	0	0	1	0	3	0	2	0	7	2	1	2	7	2	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr15:65621833T>G	uc002aos.2	-	13	2352	c.2100A>C	c.(2098-2100)GGA>GGC	p.G700G	IGDCC3_uc002aor.1_5'UTR	NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	700	Cytoplasmic (Potential).									ovary(3)	3						GGCCCCGCTGTCCCCGTCTCG	0.647													33	59					0	0	0	0	G	65621833	G	G	65621833	2	3	121	1	0	0	0	0	0	0	0	1	7607	1654	58	5		5	IGDCC3	15	65621833	Silent	SNP	T	TCGA-CR-6471-01A-11D-1870-08	9234248	65621833	36909559	117	21404											
ACAN	176	broad.mit.edu	37	chr15	89398654	89398654	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagctgagatcctagagggCtctgcctctggagttgggga	7	9	17	8	0	2	2	0	1	2	2	3	6	3	5	2	5	2	3	2	5	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr15:89398654C>T	uc010upo.1	+	12	3212	c.2838C>T	c.(2836-2838)GGC>GGT	p.G946G	ACAN_uc010upp.1_Silent_p.G946G|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	946					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TCCTAGAGGGCTCTGCCTCTG	0.557													21	63					0	0	0	0	T	89398654	T	T	89398654	2	4	121	1	0	0	0	0	0	0	0	1	117	784	28	4		4	ACAN	15	89398654	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	23776821	89398654	13132738	118	21405											
FES	2242	broad.mit.edu	37	chr15	91433462	91433462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggccccggcgagccccCgcctgtgctgctcctgcagg	2	6	14	19	3	0	0	0	0	0	0	1	1	1	0	7	3	4	3	7	3	0	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr15:91433462C>T	uc002bpv.2	+	9	1286	c.1190C>T	c.(1189-1191)CCG>CTG	p.P397L	FES_uc010uqj.1_Missense_Mutation_p.P339L|FES_uc010uqk.1_Missense_Mutation_p.P379L|FES_uc002bpw.2_RNA|FES_uc010bny.2_Missense_Mutation_p.P339L|FES_uc002bpx.2_Missense_Mutation_p.P397L|FES_uc002bpy.2_Missense_Mutation_p.P339L	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	397					axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GGCGAGCCCCCGCCTGTGCTG	0.726													11	22					0	0	0	0	T	91433462	T	T	91433462	3	4	121	1	0	0	0	0	1	0	0	0	5852	652	23	1	1220	1	FES	15	91433462	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	2034808	91433462	11097930	119	21406											
RAB40C	57799	broad.mit.edu	37	chr16	640410	640410	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcaggacggcgcggcagAgtccccgtacgcctacagta	8	5	13	15	5	0	1	0	0	0	1	1	2	1	2	4	3	3	4	4	3	3	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr16:640410A>G	uc002chr.2	+	1	235	c.119A>G	c.(118-120)GAG>GGG	p.E40G	RAB40C_uc002chq.2_Missense_Mutation_p.E40G	NM_021168	NP_066991	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	40					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0		Hepatocellular(780;0.0218)				GGCGCGGCAGAGTCCCCGTAC	0.612													7	24					0	0	0	0	G	640410	G	G	640410	3	3	121	1	0	0	0	0	1	0	0	0	13007	304	11	5	121	5	RAB40C	16	640410	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08		640410	89714343	120	21407											
PTX4	390667	broad.mit.edu	37	chr16	1538463	1538463	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgacctcccagtttccactCcccatgacactacccggccc	7	8	6	20	1	0	2	0	2	0	0	3	2	3	2	7	1	1	1	7	1	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr16:1538463C>T	uc010uvf.1	-	1	6	c.6G>A	c.(4-6)GGG>GGA	p.G2G		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	Error:Variant_position_missing_in_Q96A99_after_alignment						extracellular region	metal ion binding				0						AGTTTCCACTCCCCATGACAC	0.652													3	33					0	0	0	0	T	1538463	T	T	1538463	2	4	121	1	0	0	0	0	0	0	0	1	12888	842	30	2		2	PTX4	16	1538463	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	898053	1538463	88816290	121	21408											
CREBBP	1387	broad.mit.edu	37	chr16	3781253	3781253	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcactcgttgcaggtgtaGacaaagcggtcctggccctg	7	10	13	11	2	0	1	0	0	0	1	2	1	1	1	2	3	3	4	2	3	2	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr16:3781253G>C	uc002cvv.2	-	30	5316	c.5112C>G	c.(5110-5112)GTC>GTG	p.V1704V	CREBBP_uc002cvw.2_Silent_p.V1666V	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1704	Interaction with TRERF1.|ZZ-type.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGCAGGTGTAGACAAAGCGGT	0.662			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				13	57					0	0	0	0	C	3781253	C	C	3781253	2	2	121	1	0	0	0	0	0	0	0	1	3876	929	33	2		2	CREBBP	16	3781253	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	2242790	3781253	86573500	122	21409											
CLEC16A	23274	broad.mit.edu	37	chr16	11114117	11114117	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccagcacctccgtgcaggaGcagaacaccacggacgagga	12	2	13	14	3	0	1	0	0	0	1	1	5	1	4	4	3	4	3	4	3	1	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr16:11114117G>A	uc002dao.2	+	12	1601	c.1371G>A	c.(1369-1371)GAG>GAA	p.E457E	CLEC16A_uc002dan.3_Silent_p.E439E	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	457								p.0?(1)		ovary(1)|central_nervous_system(1)	2						CCGTGCAGGAGCAGAACACCA	0.597													11	28					0	0	0	0	A	11114117	A	A	11114117	2	1	121	1	0	0	0	0	0	0	0	1	3515	962	34	4		4	CLEC16A	16	11114117	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	7332864	11114117	79240636	123	21410											
LOC81691	81691	broad.mit.edu	37	chr16	20856094	20856094	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctattgcaggagccccgcctCtttcttggcctggaagctgt	5	12	11	13	1	2	0	0	0	2	0	2	2	2	2	4	3	3	2	4	3	2	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr16:20856094C>G	uc002dhv.2	+	17	2126	c.1863C>G	c.(1861-1863)CTC>CTG	p.L621L	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Silent_p.L590L|LOC81691_uc002dhw.2_Silent_p.L364L|LOC81691_uc002dhy.3_Silent_p.L621L	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	621	RRM 2.					nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						AGCCCCGCCTCTTTCTTGGCC	0.428													29	82					0	0	0	0	G	20856094	G	G	20856094	2	3	121	1	0	0	0	0	0	0	0	1	8940	900	32	2		2	LOC81691	16	20856094	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	9741977	20856094	69498659	124	21411											
ZKSCAN2	342357	broad.mit.edu	37	chr16	25258086	25258086	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcagacttgcggataaattcGatgcctatttcatcatcatc	11	14	6	10	2	4	1	4	0	0	1	6	3	4	2	1	1	2	0	1	1	3	5	rs149172025	by1000genomes	TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr16:25258086G>A	uc002dod.3	-	5	1838	c.1431C>T	c.(1429-1431)ATC>ATT	p.I477I	ZKSCAN2_uc010vcl.1_Silent_p.I273I|ZKSCAN2_uc002doe.2_Silent_p.I477I	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	477					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		GGATAAATTCGATGCCTATTT	0.448													28	92					0	0	0	0	A	25258086	A	A	25258086	2	1	121	1	0	0	0	0	0	0	0	1	17754	1048	37	1		1	ZKSCAN2	16	25258086	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	4401992	25258086	65096667	125	21412											
SETD1A	9739	broad.mit.edu	37	chr16	30980949	30980949	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggatgacgaggaagatgaGgaagatgaagatcgagagga	17	4	18	2	2	0	7	0	3	0	4	1	14	0	11	0	4	0	0	0	4	3	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr16:30980949G>A	uc002ead.1	+	12	3641	c.2955G>A	c.(2953-2955)GAG>GAA	p.E985E		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	985	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						AGGAAGATGAGGAAGATGAAG	0.507													7	31					0	0	0	0	A	30980949	A	A	30980949	2	1	121	1	0	0	0	0	0	0	0	1	14195	991	35	4		4	SETD1A	16	30980949	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	5722863	30980949	59373804	126	21413											
MBTPS1	8720	broad.mit.edu	37	chr16	84115471	84115472	+	Frame_Shift_Ins	INS	-	T	T																															ctgacgcgatcagggcctgcINSttcatactggcgggattcac																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr16:84115471_84115472insT	uc002fhi.2	-	11	1830_1831	c.1328_1329insA	c.(1327-1329)AAGfs	p.K443fs		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	443	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						TCAGGGCCTGCTTCATACTGGC	0.525													---	---	---								T	84115472	T	T	84115471	7	5	121	1	0	1	1	0	0	0	0	0	9414	796	28	0	1881	0	MBTPS1	16	84115471	Frame_Shift_Ins	INS	-	TCGA-CR-6471-01A-11D-1870-08	53134522	84115471	6239282	127	21414											
TAF1C	9013	broad.mit.edu	37	chr16	84217036	84217036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctcagtcacatccagcaCgactcggggccgcttccgat	7	8	10	16	4	2	0	2	0	0	0	5	2	4	0	3	2	2	3	3	2	0	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr16:84217036C>T	uc002fhn.2	-	4	526	c.298G>A	c.(298-300)GTG>ATG	p.V100M	TAF1C_uc002fhm.2_Missense_Mutation_p.V33M|TAF1C_uc010vnx.1_Missense_Mutation_p.V100M|TAF1C_uc010vny.1_Translation_Start_Site|TAF1C_uc010vnz.1_Translation_Start_Site|TAF1C_uc002fho.2_Translation_Start_Site|TAF1C_uc010voa.1_Intron|TAF1C_uc002fhp.1_RNA|TAF1C_uc010vob.1_Missense_Mutation_p.V100M	NM_005679	NP_005670	Q15572	TAF1C_HUMAN	TBP-associated factor 1C isoform 1	100					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			ovary(1)	1						ACATCCAGCACGACTCGGGGC	0.637													8	16					0	0	0	0	T	84217036	T	T	84217036	3	4	121	1	0	0	0	0	1	0	0	0	15587	536	19	1	2355	1	TAF1C	16	84217036	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	101565	84217036	6137717	128	21415											
GEMIN4	50628	broad.mit.edu	37	chr17	649755	649755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcaacttttcagagaggcCctttcgcccccaggaacgca	10	7	9	15	2	1	1	1	0	0	1	2	3	1	2	3	2	3	2	3	2	2	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr17:649755C>T	uc002frs.1	-	2	1647	c.1528G>A	c.(1528-1530)GGC>AGC	p.G510S		NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	510					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		TCAGAGAGGCCCTTTCGCCCC	0.527													14	25					0	0	0	0	T	649755	T	T	649755	3	4	121	1	0	0	0	0	1	0	0	0	6367	623	22	4	1652	4	GEMIN4	17	649755	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08		649755	80545455	129	21416											
KIF1C	10749	broad.mit.edu	37	chr17	4926827	4926827	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgcctgaaggatcagaggCagcagaggaggcagccccca	11	2	14	14	1	1	3	1	1	0	2	1	5	1	5	4	4	2	3	4	4	1	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr17:4926827C>T	uc002gan.1	+	23	3019	c.2693C>T	c.(2692-2694)GCA>GTA	p.A898V		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	898					microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						GGATCAGAGGCAGCAGAGGAG	0.637													11	35					0	0	0	0	T	4926827	T	T	4926827	3	4	121	1	0	0	0	0	1	0	0	0	8324	710	25	4	2775	4	KIF1C	17	4926827	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	4277072	4926827	76268383	130	21417											
ZNF594	84622	broad.mit.edu	37	chr17	5086056	5086056	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgaataaggagtgaacgcCgcctgaaggctttcccacat	11	9	11	10	2	0	3	0	3	0	0	1	4	1	4	3	2	1	2	3	2	4	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr17:5086056C>T	uc010cla.1	-	2	1652	c.1496G>A	c.(1495-1497)CGG>CAG	p.R499Q		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	499	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						GAGTGAACGCCGCCTGAAGGC	0.478													11	58					0	0	0	0	T	5086056	T	T	5086056	3	4	121	1	0	0	0	0	1	0	0	0	18091	652	23	1	931	1	ZNF594	17	5086056	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	159229	5086056	76109154	131	21418											
KRBA2	124751	broad.mit.edu	37	chr17	8273377	8273377	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccttatgtacataatacCgtattcgatcacgttctcca	10	15	4	12	3	2	0	1	0	1	0	5	1	3	0	3	0	2	3	3	0	5	8			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr17:8273377C>T	uc002glf.1	-	2	560	c.554G>A	c.(553-555)CGG>CAG	p.R185Q	KRBA2_uc002glg.1_Missense_Mutation_p.R102Q	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	185					DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						TACATAATACCGTATTCGATC	0.443													47	127					0	0	0	0	T	8273377	T	T	8273377	3	4	121	1	0	0	0	0	1	0	0	0	8479	652	23	1	928	1	KRBA2	17	8273377	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	3187321	8273377	72921833	132	21419											
MYO18A	399687	broad.mit.edu	37	chr17	27423781	27423781	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcagggggcccacccacctCctctgcttcttctccagttc	4	10	9	18	0	3	0	0	0	3	0	6	0	4	0	5	3	1	3	5	3	0	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr17:27423781C>T	uc002hdt.1	-	28	4541	c.4383G>A	c.(4381-4383)AGG>AGA	p.R1461R	MYO18A_uc010wbc.1_Silent_p.R1003R|MYO18A_uc002hds.2_Silent_p.R1003R|MYO18A_uc010csa.1_Silent_p.R1461R|MYO18A_uc002hdu.1_Silent_p.R1461R|MYO18A_uc010wbd.1_Silent_p.R1130R	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1461	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CCACCCACCTCCTCTGCTTCT	0.627													3	10					0	0	0	0	T	27423781	T	T	27423781	2	4	121	1	0	0	0	0	0	0	0	1	10118	854	30	2		2	MYO18A	17	27423781	Silent	SNP	C	TCGA-CR-6471-01A-11D-1870-08	19150404	27423781	53771429	133	21420											
CETN1	1068	broad.mit.edu	37	chr18	580607	580607	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgggcttcgaacccaggaagGaagagatgaagaaaatgatc	16	6	13	6	1	0	4	0	2	0	2	2	8	0	6	1	3	1	1	1	3	6	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr18:580607G>C	uc002kko.1	+	1	241	c.199G>C	c.(199-201)GAA>CAA	p.E67Q		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	67	EF-hand 2.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2						ACCCAGGAAGGAAGAGATGAA	0.557													10	34					0	0	0	0	C	580607	C	C	580607	3	2	121	1	0	0	0	0	1	0	0	0	3289	1175	41	2	201	2	CETN1	18	580607	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08		580607	77496641	134	21421											
SMCHD1	23347	broad.mit.edu	37	chr18	2732451	2732451	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtatgatgaaggagaaagAgaaatcaatataacatcagc	20	8	9	4	0	2	4	2	2	0	2	2	6	2	4	0	1	2	1	0	1	7	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr18:2732451A>G	uc002klm.3	+	25	3426	c.3237A>G	c.(3235-3237)AGA>AGG	p.R1079R	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1079					chromosome organization		ATP binding				0						AAGGAGAAAGAGAAATCAATA	0.289													6	28					0	0	0	0	G	2732451	G	G	2732451	2	3	121	1	0	0	0	0	0	0	0	1	14852	301	11	5		5	SMCHD1	18	2732451	Silent	SNP	A	TCGA-CR-6471-01A-11D-1870-08	2151844	2732451	75344797	135	21422											
MIB1	57534	broad.mit.edu	37	chr18	19379870	19379870	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgacctcaatgaagaattaGttaaggctgctgccaatgga	13	10	11	7	0	1	3	1	2	0	1	1	4	1	4	2	2	2	3	2	2	6	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr18:19379870G>C	uc002ktq.2	+	9	1306	c.1306G>C	c.(1306-1308)GTT>CTT	p.V436L	MIB1_uc002ktp.2_Missense_Mutation_p.V75L	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	436	ANK 1.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			TGAAGAATTAGTTAAGGCTGC	0.328													21	55					0	0	0	0	C	19379870	C	C	19379870	3	2	121	1	0	0	0	0	1	0	0	0	9619	1029	36	4	1340	4	MIB1	18	19379870	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	16647419	19379870	58697378	136	21423											
SMAD2	4087	broad.mit.edu	37	chr18	45394805	45394805	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttaggatctcggtgtgtcGgggcactaatactggaggca	8	11	15	7	2	1	0	0	0	1	0	3	2	1	2	0	6	1	3	0	6	3	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr18:45394805G>A	uc002lcy.2	-	5	792	c.544C>T	c.(544-546)CGA>TGA	p.R182*	SMAD2_uc002lcz.2_Nonsense_Mutation_p.R182*|SMAD2_uc010xdc.1_Nonsense_Mutation_p.R152*|SMAD2_uc010xdd.1_Nonsense_Mutation_p.R152*	NM_005901	NP_005892	Q15796	SMAD2_HUMAN	Sma- and Mad-related protein 2 isoform 1	182					anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			large_intestine(3)|lung(1)|central_nervous_system(1)	5						TCGGTGTGTCGGGGCACTAAT	0.438													12	44					0	0	0	0	A	45394805	A	A	45394805	4	1	121	1	0	0	0	0	0	1	0	0	14822	1124	39	1	887	1	SMAD2	18	45394805	Nonsense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	26014935	45394805	32682443	137	21424											
CD226	10666	broad.mit.edu	37	chr18	67563082	67563082	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggctgcagttgctcactatTtgtcttgggaacttggaggt	6	15	13	7	0	2	0	1	0	1	0	2	2	2	2	0	4	3	4	0	4	2	5			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr18:67563082T>A	uc010dqo.2	-	3	1029	c.582A>T	c.(580-582)CAA>CAT	p.Q194H	CD226_uc002lkm.3_Missense_Mutation_p.Q194H	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	194	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				TGCTCACTATTTGTCTTGGGA	0.542													41	75					0	0	0	0	A	67563082	A	A	67563082	3	1	121	1	0	0	0	0	1	0	0	0	3001	1838	64	5	444	5	CD226	18	67563082	Missense_Mutation	SNP	T	TCGA-CR-6471-01A-11D-1870-08	22168277	67563082	10514166	138	21425											
ZNF407	55628	broad.mit.edu	37	chr18	72343009	72343009	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaataaacccgaaaatgatGaggatgaaaagataaacaaa	24	5	8	4	1	0	5	0	3	0	2	0	7	0	6	1	1	2	0	1	1	10	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr18:72343009G>A	uc002llw.2	+	1	91	c.34G>A	c.(34-36)GAG>AAG	p.E12K	ZNF407_uc010xfc.1_Missense_Mutation_p.E12K|ZNF407_uc010dqu.1_Missense_Mutation_p.E12K|ZNF407_uc002llu.2_Missense_Mutation_p.E11K	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	12					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CGAAAATGATGAGGATGAAAA	0.408													7	18					0	0	0	0	A	72343009	A	A	72343009	3	1	121	1	0	0	0	0	1	0	0	0	17954	1291	45	2	36	2	ZNF407	18	72343009	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	4779927	72343009	5734239	139	21426											
NFATC1	4772	broad.mit.edu	37	chr18	77208983	77208983	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagaacagcatgcgagccGtgtaagccgcgggggacctc	9	4	16	12	5	0	1	0	0	0	1	1	4	0	2	3	3	5	2	3	3	2	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr18:77208983G>A	uc010xfg.1	+	4	2041	c.1588G>A	c.(1588-1590)GTC>ATC	p.V530I	NFATC1_uc002lnc.1_Missense_Mutation_p.V530I|NFATC1_uc010xff.1_Missense_Mutation_p.V530I|NFATC1_uc002lnd.2_Missense_Mutation_p.V530I|NFATC1_uc002lne.2_Missense_Mutation_p.V58I|NFATC1_uc010xfh.1_Missense_Mutation_p.V530I|NFATC1_uc010xfi.1_Missense_Mutation_p.V517I|NFATC1_uc010xfj.1_Missense_Mutation_p.V58I|NFATC1_uc002lnf.2_Missense_Mutation_p.V517I|NFATC1_uc002lng.2_Missense_Mutation_p.V517I|NFATC1_uc010xfk.1_Missense_Mutation_p.V517I	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	530	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CATGCGAGCCGTGTAAGCCGC	0.687													8	27					0	0	0	0	A	77208983	A	A	77208983	3	1	121	1	0	0	0	0	1	0	0	0	10415	1159	40	1	1694	1	NFATC1	18	77208983	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	4865974	77208983	868265	140	21427											
FUT5	2527	broad.mit.edu	37	chr19	5867522	5867522	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggatcagtagggtggggtggGcaggggtcgccatgctgtcc	5	8	20	8	1	1	0	1	0	0	0	3	1	2	1	2	7	1	3	2	7	1	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr19:5867522G>A	uc002mdo.3	-	2	303	c.215C>T	c.(214-216)GCC>GTC	p.A72V	FUT5_uc010duo.2_Missense_Mutation_p.A72V	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	72	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						GGTGGGGTGGGCAGGGGTCGC	0.662													15	51					0	0	0	0	A	5867522	A	A	5867522	3	1	121	1	0	0	0	0	1	0	0	0	6141	1203	42	4	913	4	FUT5	19	5867522	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08		5867522	53261461	141	21428											
ZNF440	126070	broad.mit.edu	37	chr19	11942501	11942501	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggatcacactggagagaaAcccaatgcttgtaaagtatg	15	8	11	7	0	1	1	1	0	0	1	1	4	1	3	1	2	2	3	1	2	5	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr19:11942501A>G	uc002msp.1	+	4	666	c.510A>G	c.(508-510)AAA>AAG	p.K170K		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTGGAGAGAAACCCAATGCTT	0.413													54	103					0	0	0	0	G	11942501	G	G	11942501	2	3	121	1	0	0	0	0	0	0	0	1	17980	40	2	5		5	ZNF440	19	11942501	Silent	SNP	A	TCGA-CR-6471-01A-11D-1870-08	6074979	11942501	47186482	142	21429											
ZNF443	10224	broad.mit.edu	37	chr19	12541096	12541096	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctttttatgtctatgcaaGgaactgagagaagcaaatgc	13	12	10	6	0	2	2	0	1	2	1	2	4	2	3	0	1	4	2	0	1	6	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr19:12541096G>A	uc002mtu.2	-	4	2088	c.1890C>T	c.(1888-1890)TCC>TCT	p.S630S		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	630	C2H2-type 18.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						GTCTATGCAAGGAACTGAGAG	0.403													22	96					0	0	0	0	A	12541096	A	A	12541096	2	1	121	1	0	0	0	0	0	0	0	1	17983	987	35	4		4	ZNF443	19	12541096	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08	598595	12541096	46587887	143	21430											
EPS15L1	58513	broad.mit.edu	37	chr19	16552783	16552783	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccccaccctccctgtgtatgCcggatcgacctgaaatggga	8	8	10	15	2	0	1	0	1	0	0	2	4	1	3	6	2	1	1	6	2	2	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr19:16552783C>T	uc002ndz.1	-	3	91	c.85G>A	c.(85-87)GCA>ACA	p.A29T	EPS15L1_uc002ndx.2_Missense_Mutation_p.A29T|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpf.1_5'UTR|EPS15L1_uc002nea.1_Missense_Mutation_p.A29T|EPS15L1_uc010eah.1_Missense_Mutation_p.A29T|EPS15L1_uc002nec.1_Missense_Mutation_p.A29T	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	29	EH 1.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						CCTGTGTATGCCGGATCGACC	0.512											OREG0025335	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	123					0	0	0	0	T	16552783	T	T	16552783	3	4	121	1	0	0	0	0	1	0	0	0	5217	739	26	4	2593	4	EPS15L1	19	16552783	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	4011687	16552783	42576200	144	21431											
KIAA1683	80726	broad.mit.edu	37	chr19	18378184	18378184	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttggacttgaggccctcgtGctggggctgtggaggcgctt	3	11	17	10	2	0	1	0	1	0	0	1	3	0	3	1	6	1	3	1	6	0	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr19:18378184G>A	uc002nin.2	-	3	382	c.166C>T	c.(166-168)CAC>TAC	p.H56Y	KIAA1683_uc010ebn.2_Missense_Mutation_p.H56Y|KIAA1683_uc010xqe.1_Missense_Mutation_p.H10Y	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	56						mitochondrion				ovary(2)	2						AGGCCCTCGTGCTGGGGCTGT	0.657													31	76					0	0	0	0	A	18378184	A	A	18378184	3	1	121	1	0	0	0	0	1	0	0	0	8290	1319	46	4	3945	4	KIAA1683	19	18378184	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	1825401	18378184	40750799	145	21432											
ZNF99	7652	broad.mit.edu	37	chr19	22941426	22941426	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttaaaagctttgccacattCttcacatttgcagggtttct	9	16	6	10	0	3	0	1	0	2	0	3	0	3	0	1	1	3	3	1	1	2	6			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr19:22941426C>T	uc010xrh.1	-	5	1012	c.1012G>A	c.(1012-1014)GAA>AAA	p.E338K		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTGCCACATTCTTCACATTTG	0.373													13	47					0	0	0	0	T	22941426	T	T	22941426	3	4	121	1	0	0	0	0	1	0	0	0	18271	922	32	2	2112	2	ZNF99	19	22941426	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	4563242	22941426	36187557	146	21433											
GRIK5	2901	broad.mit.edu	37	chr19	42546827	42546827	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctcggccagctcccgcagCatgtccacgcagaagccctc	8	5	10	18	3	0	1	0	0	0	1	4	1	2	1	4	1	4	5	4	1	1	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr19:42546827C>T	uc002osj.1	-	11	1385	c.1350G>A	c.(1348-1350)ATG>ATA	p.M450I	GRIK5_uc002osi.1_Missense_Mutation_p.M22I|GRIK5_uc010eib.1_Missense_Mutation_p.M369I	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	450	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GCTCCCGCAGCATGTCCACGC	0.677													14	25					0	0	0	0	T	42546827	T	T	42546827	3	4	121	1	0	0	0	0	1	0	0	0	6816	710	25	4	1628	4	GRIK5	19	42546827	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	19605401	42546827	16582156	147	21434											
ZC3H4	23211	broad.mit.edu	37	chr19	47570458	47570458	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgcccgggcgctgccgggCgttggggggccctgccgtgg	0	5	22	14	6	0	0	0	0	0	0	0	0	0	0	4	7	2	2	4	7	0	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr19:47570458C>T	uc002pga.3	-	15	3105	c.3067G>A	c.(3067-3069)GCC>ACC	p.A1023T	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1023							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CGCTGCCGGGCGTTGGGGGGC	0.706													13	24					0	0	0	0	T	47570458	T	T	47570458	3	4	121	1	0	0	0	0	1	0	0	0	17637	768	27	1	848	1	ZC3H4	19	47570458	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	5023631	47570458	11558525	148	21435											
PTPRH	5794	broad.mit.edu	37	chr19	55711682	55711682	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaatgtgtacaaggttcCgggctcaagtctctcagctg	10	10	12	9	1	3	1	2	0	1	1	5	2	4	1	1	2	2	4	1	2	4	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr19:55711682C>T	uc002qjq.2	-	7	1415	c.1342G>A	c.(1342-1344)GGA>AGA	p.G448R	PTPRH_uc010esv.2_Missense_Mutation_p.G270R|PTPRH_uc002qjs.2_Missense_Mutation_p.G455R	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	448	Extracellular (Potential).|Fibronectin type-III 5.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TACAAGGTTCCGGGCTCAAGT	0.522													27	89					0	0	0	0	T	55711682	T	T	55711682	3	4	121	1	0	0	0	0	1	0	0	0	12868	661	23	1	2061	1	PTPRH	19	55711682	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	8141224	55711682	3417301	149	21436											
ZNF460	10794	broad.mit.edu	37	chr19	57803220	57803220	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgcatgtcagggctcacaagGcaccagtggattcatactgg	10	8	12	11	1	3	0	3	0	0	0	3	1	3	1	1	4	1	3	1	4	2	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr19:57803220G>T	uc002qog.2	+	3	1633	c.1311G>T	c.(1309-1311)AGG>AGT	p.R437S	ZNF460_uc010ygv.1_Missense_Mutation_p.R396S	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	437	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGCTCACAAGGCACCAGTGGA	0.478													17	48					1.99824e-07	2.15111e-07	1	0	T	57803220	T	T	57803220	3	4	121	1	0	0	0	0	1	0	0	0	17991	1194	42	4	1321	4	ZNF460	19	57803220	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	2091538	57803220	1325763	150	21437											
SIRPB2	284759	broad.mit.edu	37	chr20	1456848	1456848	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccatgctaaggtgttcatGgctcctgctgggcctgtggt	4	13	13	11	0	1	0	1	0	0	0	3	0	3	0	3	4	2	4	3	4	1	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr20:1456848G>T	uc002wfg.2	-	5	1221	c.993C>A	c.(991-993)GCC>GCA	p.A331A	SIRPB2_uc002wfh.3_Silent_p.A233A	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	331	Cytoplasmic (Potential).					integral to membrane					0						AGGTGTTCATGGCTCCTGCTG	0.592													36	109					3.21399e-22	3.72445e-22	1	0	T	1456848	T	T	1456848	2	4	121	1	0	0	0	0	0	0	0	1	14399	1335	47	4		4	SIRPB2	20	1456848	Silent	SNP	G	TCGA-CR-6471-01A-11D-1870-08		1456848	61568672	151	21438											
SNAP25	6616	broad.mit.edu	37	chr20	10256162	10256162	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccgaagacgcagacatgcGcaatgagctggaggagatgc	12	4	16	9	3	0	4	0	1	0	3	0	7	0	5	1	3	3	3	1	3	2	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr20:10256162G>A	uc002wnq.1	+	2	235	c.23G>A	c.(22-24)CGC>CAC	p.R8H	SNAP25_uc002wnr.1_Missense_Mutation_p.R8H|SNAP25_uc002wns.1_5'UTR|SNAP25_uc010gca.1_Missense_Mutation_p.R8H|SNAP25_uc010gcb.1_5'UTR|SNAP25_uc010gcc.1_5'UTR	NM_130811	NP_570824	P60880	SNP25_HUMAN	synaptosomal-associated protein 25 isoform	8	Interaction with CENPF (By similarity).				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				skin(2)	2					Botulinum Toxin Type A(DB00083)	GCAGACATGCGCAATGAGCTG	0.602													7	25					0	0	0	0	A	10256162	A	A	10256162	3	1	121	1	0	0	0	0	1	0	0	0	14894	1087	38	1	25	1	SNAP25	20	10256162	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	8799314	10256162	52769358	152	21439											
DNMT3B	1789	broad.mit.edu	37	chr20	31395666	31395666	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggagcgtgcctgtcatccGacacctcttcgcccctctga	5	10	9	17	3	3	1	1	1	2	0	5	3	4	2	5	1	2	0	5	1	0	1	rs121908946		TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr20:31395666G>A	uc002wyc.2	+	23	2840	c.2519G>A	c.(2518-2520)CGA>CAA	p.R840Q	DNMT3B_uc002wyd.2_Missense_Mutation_p.R820Q|DNMT3B_uc002wye.2_Missense_Mutation_p.R757Q|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.R715Q|DNMT3B_uc010zua.1_Missense_Mutation_p.R681Q|DNMT3B_uc002wyf.2_Missense_Mutation_p.R832Q|DNMT3B_uc002wyg.2_Missense_Mutation_p.R476Q|DNMT3B_uc010geg.2_Silent_p.P99P|DNMT3B_uc010geh.2_RNA	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	840			R -> Q (in ICF).		negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						CCTGTCATCCGACACCTCTTC	0.602													35	106					0	0	0	0	A	31395666	A	A	31395666	3	1	121	1	0	0	0	0	1	0	0	0	4699	1058	37	1	2645	1	DNMT3B	20	31395666	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08	21139504	31395666	31629854	153	21440											
KRTAP10-5	386680	broad.mit.edu	37	chr21	46000227	46000228	+	Missense_Mutation	DNP	CC	TT	TT																															gggggaggaggcgcagcaagCcggctggcagcacgagggcg																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr21:46000227_46000228CC>TT	uc002zfl.1	-	1	254_255	c.228_229GG>AA	c.(226-231)CCGGCT>CCAACT	p.A77T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198694	NP_941967	P60370	KR105_HUMAN	keratin associated protein 10-5	77	3.|22 X 5 AA repeats of C-C-X(3).					keratin filament					0						gcgcagcaagccggctggcagc	0.292													4	72					0	0	0	0	TT	46000228	TT	TT	46000227	3	4	121	1	0	0	0	0	1	0	0	0	8551	739	26	4	590	4	KRTAP10-5	21	46000227	Missense_Mutation	DNP	CC	TCGA-CR-6471-01A-11D-1870-08		46000227	2129668	154	21441											
RTDR1	27156	broad.mit.edu	37	chr22	23401824	23401824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccttggtggcattcaggcgcGctatggtcatgggggagtgc	5	10	17	9	2	2	0	2	0	0	0	2	1	2	1	1	6	1	2	1	6	1	3			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr22:23401824G>A	uc002zwt.2	-	7	1021	c.863C>T	c.(862-864)GCG>GTG	p.A288V		NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	288							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		ATTCAGGCGCGCTATGGTCAT	0.657													16	119					0	0	0	0	A	23401824	A	A	23401824	3	1	121	1	0	0	0	0	1	0	0	0	13784	1087	38	1	187	1	RTDR1	22	23401824	Missense_Mutation	SNP	G	TCGA-CR-6471-01A-11D-1870-08		23401824	27902742	155	21442											
LIMK2	3985	broad.mit.edu	37	chr22	31655979	31655979	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcacgctcatctccatgcCggccaccactgaaggcaggc	8	7	10	16	2	3	1	2	1	1	0	4	1	3	1	4	3	1	2	4	3	1	0			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr22:31655979C>T	uc003akh.2	+	5	612	c.467C>T	c.(466-468)CCG>CTG	p.P156L	LIMK2_uc003akg.2_Missense_Mutation_p.P73L|LIMK2_uc003aki.2_Intron|LIMK2_uc003akj.2_Missense_Mutation_p.P135L|LIMK2_uc003akk.2_Missense_Mutation_p.P135L|LIMK2_uc011aln.1_Missense_Mutation_p.P73L	NM_005569	NP_005560	P53671	LIMK2_HUMAN	LIM domain kinase 2 isoform 2a	156	PDZ.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2						ATCTCCATGCCGGCCACCACT	0.557													4	77					0	0	0	0	T	31655979	T	T	31655979	3	4	121	1	0	0	0	0	1	0	0	0	8843	652	23	1	542	1	LIMK2	22	31655979	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	8254155	31655979	19648587	156	21443											
EP300	2033	broad.mit.edu	37	chr22	41566460	41566460	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accaagtgagggagatgattAtatcttccattgccatcctc	11	12	8	10	0	1	3	0	2	1	1	4	4	3	3	4	1	1	0	4	1	3	4			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chr22:41566460A>G	uc003azl.3	+	27	4732	c.4337A>G	c.(4336-4338)TAT>TGT	p.Y1446C		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1446					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGAGATGATTATATCTTCCAT	0.408			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				52	72					0	0	0	0	G	41566460	G	G	41566460	3	3	121	1	0	0	0	0	1	0	0	0	5172	449	16	5	4443	5	EP300	22	41566460	Missense_Mutation	SNP	A	TCGA-CR-6471-01A-11D-1870-08	9910481	41566460	9738106	157	21444											
HUWE1	10075	broad.mit.edu	37	chrX	53587364	53587365	+	Frame_Shift_Ins	INS	-	G	G																															tagggatatttcctggggatINSggggggatgtctgctgcaag																										TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chrX:53587364_53587365insG	uc004dsp.2	-	56	7922_7923	c.7520_7521insC	c.(7519-7521)CCAfs	p.P2507fs	HUWE1_uc004dsn.2_Frame_Shift_Ins_p.P1331fs	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2507					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TTCCTGGGGATGGGGGGATGTC	0.495													---	---	---								G	53587365	G	G	53587364	7	5	121	1	0	1	1	0	0	0	0	0	7500	1451	51	0	5719	0	HUWE1	23	53587364	Frame_Shift_Ins	INS	-	TCGA-CR-6471-01A-11D-1870-08		53587364	101683196	158	21445											
TEX13A	56157	broad.mit.edu	37	chrX	104464900	104464900	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggcctctttgacctcaCtgggcacctcgctgtcctcc	4	11	9	17	1	2	1	1	1	1	0	5	1	4	1	5	2	1	3	5	2	0	1			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chrX:104464900C>T	uc004ema.2	-	2	294	c.182G>A	c.(181-183)AGT>AAT	p.S61N	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.S61N	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	61						intracellular	zinc ion binding			ovary(2)	2						TTTGACCTCACTGGGCACCTC	0.592													15	20					0	0	0	0	T	104464900	T	T	104464900	3	4	121	1	0	0	0	0	1	0	0	0	15842	565	20	4	1057	4	TEX13A	23	104464900	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	50877536	104464900	50805660	159	21446											
TRPC5	7224	broad.mit.edu	37	chrX	111195420	111195420	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggttctcgttctcaatggCaatgagcagggcactccggc	8	9	12	12	2	2	1	1	1	2	0	5	1	3	1	1	4	1	5	1	4	2	2			TCGA-CR-6471-01A-11D-1870-08	TCGA-CR-6471-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c087e87f-867c-45dd-8645-5ab774e4827c	98949b5b-2be7-4de5-946a-3b2e3c630415	g.chrX:111195420C>A	uc004epl.1	-	2	1148	c.229G>T	c.(229-231)GCC>TCC	p.A77S	TRPC5_uc004epm.1_Missense_Mutation_p.A77S	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	77	ANK 2.|Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						TTCTCAATGGCAATGAGCAGG	0.527													26	39					2.85442e-18	3.2693e-18	1	0	A	111195420	A	A	111195420	3	1	121	1	0	0	0	0	1	0	0	0	16649	710	25	4	2732	4	TRPC5	23	111195420	Missense_Mutation	SNP	C	TCGA-CR-6471-01A-11D-1870-08	6730520	111195420	44075140	160	21447											
DNAJC11	55735	broad.mit.edu	37	chr1	6698379	6698379	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactccgcctcttgcttcttCtgcagcacatcggtggcggc	4	11	11	15	3	3	0	0	0	3	0	5	1	4	0	2	3	3	3	2	3	0	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:6698379C>T	uc001aof.2	-	12	1405	c.1299G>A	c.(1297-1299)CAG>CAA	p.Q433Q	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Silent_p.Q381Q|DNAJC11_uc010nzu.1_Silent_p.Q343Q	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	433	Potential.				protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CTTGCTTCTTCTGCAGCACAT	0.632													23	20					0	0	0	0	T	6698379	T	T	6698379	2	4	122	1	0	0	0	0	0	0	0	1	4652	912	32	2		2	DNAJC11	1	6698379	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08		6698379	242552242	1	21448											
PIK3CD	5293	broad.mit.edu	37	chr1	9777022	9777022	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcaccccgtctcagtacatCtgcagctgcctgcacagtgg	7	9	10	15	1	2	0	1	0	2	0	3	0	2	0	3	1	6	5	3	1	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:9777022C>G	uc001aqb.3	+	7	994	c.786C>G	c.(784-786)ATC>ATG	p.I262M	PIK3CD_uc010oaf.1_Missense_Mutation_p.I262M|PIK3CD_uc001aqe.3_Intron	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	262					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		CTCAGTACATCTGCAGCTGCC	0.662													25	19					0	0	0	0	G	9777022	G	G	9777022	3	3	122	1	0	0	0	0	1	0	0	0	11970	903	32	2	804	2	PIK3CD	1	9777022	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	3078643	9777022	239473599	2	21449											
CASZ1	54897	broad.mit.edu	37	chr1	10707968	10707968	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgacgctgggatctgaggCatctggggtatggtggaagc	8	9	17	7	1	2	2	0	2	2	0	2	4	2	4	0	6	1	3	0	6	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:10707968C>T	uc001aro.2	-	16	3707	c.3387G>A	c.(3385-3387)ATG>ATA	p.M1129I	CASZ1_uc001arp.1_Missense_Mutation_p.M1129I	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1129	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GGATCTGAGGCATCTGGGGTA	0.667													32	15					0	0	0	0	T	10707968	T	T	10707968	3	4	122	1	0	0	0	0	1	0	0	0	2697	710	25	4	1920	4	CASZ1	1	10707968	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	930946	10707968	238542653	3	21450											
ALPL	249	broad.mit.edu	37	chr1	21903031	21903031	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggtctggcccccatgctGagtgacacagacaagaagcc	11	5	12	13	0	1	4	0	2	1	2	1	4	1	4	3	2	2	2	3	2	2	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:21903031G>A	uc001bet.2	+	11	1463	c.1206G>A	c.(1204-1206)CTG>CTA	p.L402L	ALPL_uc010odn.1_Silent_p.L350L|ALPL_uc010odo.1_Silent_p.L347L|ALPL_uc010odp.1_Silent_p.L325L|ALPL_uc001beu.3_Silent_p.L402L	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	402					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	CCCCCATGCTGAGTGACACAG	0.607													49	65					0	0	0	0	A	21903031	A	A	21903031	2	1	122	1	0	0	0	0	0	0	0	1	547	1277	45	2		2	ALPL	1	21903031	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	11195063	21903031	227347590	4	21451											
LDLRAD2	401944	broad.mit.edu	37	chr1	22148095	22148095	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accccacgagacaagacgcaGctttggaaggttacaccttg	12	7	10	12	2	0	2	0	0	0	2	0	4	0	3	3	2	2	3	3	2	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:22148095G>C	uc001bfg.1	+	4	983	c.796G>C	c.(796-798)GCT>CCT	p.A266P	LDLRAD2_uc001bfh.1_RNA	NM_001013693	NP_001013715	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain	266	Cytoplasmic (Potential).					integral to membrane	receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		ACAAGACGCAGCTTTGGAAGG	0.602													39	64					0	0	0	0	C	22148095	C	C	22148095	3	2	122	1	0	0	0	0	1	0	0	0	8746	971	34	4	810	4	LDLRAD2	1	22148095	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	245064	22148095	227102526	5	21452											
WASF2	10163	broad.mit.edu	37	chr1	27755376	27755376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acggcacaggtgccttggctCgatgttcctcgttactaacg	7	11	11	12	4	0	0	0	0	0	0	3	1	1	0	2	3	3	4	2	3	2	4	rs151177492		TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:27755376C>T	uc001bof.1	-	2	241	c.25G>A	c.(25-27)GAG>AAG	p.E9K	WASF2_uc010ofl.1_Missense_Mutation_p.E9K	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	9					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		TGCCTTGGCTCGATGTTCCTC	0.488													30	26					0	0	0	0	T	27755376	T	T	27755376	3	4	122	1	0	0	0	0	1	0	0	0	17321	893	31	1	1503	1	WASF2	1	27755376	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	5607281	27755376	221495245	6	21453											
KIAA0319L	79932	broad.mit.edu	37	chr1	35921704	35921704	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagtgctctggttcccaaaGagggtgatggagttttgggg	7	12	16	6	0	2	2	1	1	1	1	3	3	3	3	1	5	1	3	1	5	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:35921704G>A	uc001byx.2	-	10	1824	c.1566C>T	c.(1564-1566)CTC>CTT	p.L522L	KIAA0319L_uc001byw.2_5'Flank|KIAA0319L_uc010ohv.1_Silent_p.L164L	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	522	PKD 3.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GGTTCCCAAAGAGGGTGATGG	0.547													116	172					0	0	0	0	A	35921704	A	A	35921704	2	1	122	1	0	0	0	0	0	0	0	1	8208	929	33	2		2	KIAA0319L	1	35921704	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8166328	35921704	213328917	7	21454											
EIF2C4	192670	broad.mit.edu	37	chr1	36298161	36298161	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagaaacaatgtagggaaGatttactaaagtgagtatct	16	11	9	5	0	2	3	1	1	1	2	2	4	2	4	0	1	2	2	0	1	8	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:36298161G>C	uc001bzj.1	+	11	1559	c.1369G>C	c.(1369-1371)GAT>CAT	p.D457H		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	457					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATGTAGGGAAGATTTACTAAA	0.393													26	64					0	0	0	0	C	36298161	C	C	36298161	3	2	122	1	0	0	0	0	1	0	0	0	5030	942	33	2	1411	2	EIF2C4	1	36298161	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	376457	36298161	212952460	8	21455											
MACF1	23499	broad.mit.edu	37	chr1	39852945	39852945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttgaggacctggttggatGataaacaaagccagcaagca	15	7	12	7	0	0	2	0	2	0	0	0	4	0	4	2	3	4	4	2	3	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:39852945G>A	uc010oiu.1	+	22	9882	c.9751G>A	c.(9751-9753)GAT>AAT	p.D3251N	MACF1_uc010ois.1_Missense_Mutation_p.D2749N|MACF1_uc001cda.1_Missense_Mutation_p.D2636N|MACF1_uc001cdc.1_Missense_Mutation_p.D1815N	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4816	Spectrin 4.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTGGTTGGATGATAAACAAAG	0.448													106	161					0	0	0	0	A	39852945	A	A	39852945	3	1	122	1	0	0	0	0	1	0	0	0	9195	1290	45	2	14606	2	MACF1	1	39852945	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3554784	39852945	209397676	9	21456											
MACF1	23499	broad.mit.edu	37	chr1	39907972	39907972	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctctgggagaacctgggtGagaaaattgcccaccgacag	12	6	12	11	1	1	2	0	1	1	2	1	5	1	2	4	2	2	0	4	2	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:39907972G>A	uc010oiu.1	+	41	14388	c.14257G>A	c.(14257-14259)GAG>AAG	p.E4753K	MACF1_uc010ois.1_Missense_Mutation_p.E4251K	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAACCTGGGTGAGAAAATTGC	0.448													17	36					0	0	0	0	A	39907972	A	A	39907972	3	1	122	1	0	0	0	0	1	0	0	0	9195	1291	45	2	19188	2	MACF1	1	39907972	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	55027	39907972	209342649	10	21457											
HIVEP3	59269	broad.mit.edu	37	chr1	41976891	41976904	+	Frame_Shift_Del	DEL	TGAGCAGGGCCGGG	-	-																															agggtcgggaggagagaggaTgagcagggccgggtgagcag																								rs147310017		TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:41976891_41976904delTGAGCAGGGCCGGG	uc001cgz.3	-	9	7652_7665	c.6439_6452delCCCGGCCCTGCTCA	c.(6439-6453)CCCGGCCCTGCTCATfs	p.P2147fs	HIVEP3_uc001cha.3_Frame_Shift_Del_p.P2146fs|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	2147_2151					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGAGAGAGGATGAGCAGGGCCGGGTGAGCAGGAG	0.551													---	---	---								-	41976904	-	-	41976891	7	5	122	1	0	1	0	1	0	0	0	0	7227	1464	51	0	772	0	HIVEP3	1	41976891	Frame_Shift_Del	DEL	TGAGCAGGGCCGGG	TCGA-CR-6472-01A-11D-1870-08	2068919	41976891	207273730	11	21458											
KIAA0467	23334	broad.mit.edu	37	chr1	43903370	43903370	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catctactctgaggaagcctCggcatgtatcactcccactc	9	10	7	15	1	3	1	1	1	2	0	6	2	4	2	2	2	2	2	2	2	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:43903370C>T	uc001cjk.1	+	30	4160	c.3698C>T	c.(3697-3699)TCG>TTG	p.S1233L		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2132						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GAGGAAGCCTCGGCATGTATC	0.592													21	27					0	0	0	0	T	43903370	T	T	43903370	3	4	122	1	0	0	0	0	1	0	0	0	8217	898	31	1	3808	1	KIAA0467	1	43903370	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1926479	43903370	205347251	12	21459											
KIAA0494	9813	broad.mit.edu	37	chr1	47182007	47182007	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggcatccagatcctccttGagagcaacctgcatccacac	11	7	8	15	0	0	2	0	1	0	2	4	3	4	2	5	1	3	3	5	1	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:47182007G>C	uc001cqk.3	-	2	1271	c.294C>G	c.(292-294)CTC>CTG	p.L98L	KIAA0494_uc010omh.1_Silent_p.L98L|KIAA0494_uc001cql.1_Silent_p.L98L	NM_014774	NP_055589	O75071	K0494_HUMAN	hypothetical protein LOC9813	98							calcium ion binding				0	Acute lymphoblastic leukemia(166;0.155)					GATCCTCCTTGAGAGCAACCT	0.378													13	31					0	0	0	0	C	47182007	C	C	47182007	2	2	122	1	0	0	0	0	0	0	0	1	8218	1277	45	2		2	KIAA0494	1	47182007	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3278637	47182007	202068614	13	21460											
NRD1	4898	broad.mit.edu	37	chr1	52256649	52256649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaactcttctatcttcttatCaacaacttcagaactgaaac	15	13	2	11	0	6	2	2	1	4	1	6	2	6	2	0	0	5	0	0	0	7	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:52256649C>T	uc001ctc.3	-	30	3500	c.3178G>A	c.(3178-3180)GAT>AAT	p.D1060N	NRD1_uc009vzb.2_Missense_Mutation_p.D755N|NRD1_uc001ctd.3_Missense_Mutation_p.D992N|NRD1_uc001cte.2_Missense_Mutation_p.D928N	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	991					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						ATCTTCTTATCAACAACTTCA	0.398													18	23					0	0	0	0	T	52256649	T	T	52256649	3	4	122	1	0	0	0	0	1	0	0	0	10699	826	29	2	497	2	NRD1	1	52256649	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	5074642	52256649	196993972	14	21461											
MAGOH	4116	broad.mit.edu	37	chr1	53692756	53692756	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtgtaatccaataagactGaagaccaaacacttcaggtc	17	8	7	9	0	1	3	1	1	0	2	3	3	2	3	2	1	1	1	2	1	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:53692756G>A	uc001cvf.1	-	5	490	c.402C>T	c.(400-402)TTC>TTT	p.F134F	MAGOH_uc010ont.1_Silent_p.F97F	NM_002370	NP_002361	P61326	MGN_HUMAN	mago-nashi homolog	134				KCLVF->ECLVA: Complete loss of nonsense- mediated decay activity.	mRNA 3'-end processing|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|exon-exon junction complex|nuclear speck	protein binding|RNA binding				0						CAATAAGACTGAAGACCAAAC	0.373													6	14					0	0	0	0	A	53692756	A	A	53692756	2	1	122	1	0	0	0	0	0	0	0	1	9247	1281	45	2		2	MAGOH	1	53692756	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1436107	53692756	195557865	15	21462											
C1orf87	127795	broad.mit.edu	37	chr1	60538268	60538268	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaatgattttcaccatgatCtcaggcattgcatctgatcc	10	13	6	12	0	3	3	2	3	2	0	5	3	4	3	3	1	1	2	3	1	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:60538268C>G	uc001czs.1	-	2	140	c.48G>C	c.(46-48)GAG>GAC	p.E16D		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	16							calcium ion binding			ovary(1)|breast(1)	2						TCACCATGATCTCAGGCATTG	0.393													31	67					0	0	0	0	G	60538268	G	G	60538268	3	3	122	1	0	0	0	0	1	0	0	0	2074	912	32	2	1636	2	C1orf87	1	60538268	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6845512	60538268	188712353	16	21463											
LEPR	3953	broad.mit.edu	37	chr1	66058502	66058502	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaaatcacatctggtggAgtaattttccagtcacctct	11	14	7	9	0	4	1	2	1	2	0	5	2	5	2	2	2	0	1	2	2	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:66058502A>C	uc001dci.2	+	6	859	c.657A>C	c.(655-657)GGA>GGC	p.G219G	LEPR_uc001dcg.2_Silent_p.G219G|LEPR_uc001dch.2_Silent_p.G219G|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Silent_p.G219G|LEPR_uc001dck.2_Silent_p.G219G	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	219	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CATCTGGTGGAGTAATTTTCC	0.378													13	31					0	0	0	0	C	66058502	C	C	66058502	2	2	122	1	0	0	0	0	0	0	0	1	8768	291	11	5		5	LEPR	1	66058502	Silent	SNP	A	TCGA-CR-6472-01A-11D-1870-08	5520234	66058502	183192119	17	21464											
USP33	23032	broad.mit.edu	37	chr1	78204976	78204976	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgttttcttgtatttggtGaggttgtcttacatgaggca	7	18	11	5	0	2	2	0	2	2	0	2	2	2	2	0	3	1	4	0	3	2	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:78204976G>C	uc001dht.2	-	6	765	c.418C>G	c.(418-420)CAC>GAC	p.H140D	USP33_uc001dhu.2_Missense_Mutation_p.H109D|USP33_uc001dhv.2_5'UTR|USP33_uc001dhw.2_Missense_Mutation_p.H140D	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	140					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						TGTATTTGGTGAGGTTGTCTT	0.373													45	91					0	0	0	0	C	78204976	C	C	78204976	3	2	122	1	0	0	0	0	1	0	0	0	17132	1290	45	2	2502	2	USP33	1	78204976	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	12146474	78204976	171045645	18	21465											
COL24A1	255631	broad.mit.edu	37	chr1	86252129	86252129	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agcaagacctgttcttcctgGgccgcctctgatgccctaaa	8	10	9	14	1	2	2	0	1	2	1	3	2	3	2	5	1	2	2	5	1	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:86252129G>T	uc001dlj.2	-	48	4009	c.3967C>A	c.(3967-3969)CCA>ACA	p.P1323T	COL24A1_uc001dli.2_Missense_Mutation_p.P459T|COL24A1_uc010osd.1_Missense_Mutation_p.P623T|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1323	Collagen-like 15.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GTTCTTCCTGGGCCGCCTCTG	0.463													47	67					6.08268e-21	6.59656e-21	1	0	T	86252129	T	T	86252129	3	4	122	1	0	0	0	0	1	0	0	0	3698	1232	43	4	1229	4	COL24A1	1	86252129	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8047153	86252129	162998492	19	21466											
GBP2	2634	broad.mit.edu	37	chr1	89579735	89579735	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacatttggtccacatccttGaaagagttcttcatgaagac	13	12	7	9	0	2	4	1	2	1	2	4	4	4	4	2	1	1	1	2	1	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:89579735G>C	uc001dmz.1	-	7	1384	c.1113C>G	c.(1111-1113)TTC>TTG	p.F371L	GBP2_uc001dmy.1_RNA	NM_004120	NP_004111	P32456	GBP2_HUMAN	guanylate binding protein 2,	371					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)	1		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		CCACATCCTTGAAAGAGTTCT	0.488													54	79					0	0	0	0	C	89579735	C	C	89579735	3	2	122	1	0	0	0	0	1	0	0	0	6309	1281	45	2	682	2	GBP2	1	89579735	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3327606	89579735	159670886	20	21467											
LRRC8C	84230	broad.mit.edu	37	chr1	90179681	90179681	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgggctccgaaatctggaaGagctgtacctagttggctct	9	11	12	9	1	2	1	0	0	2	1	3	3	3	2	2	3	2	5	2	3	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:90179681G>C	uc001dnl.3	+	3	1794	c.1552G>C	c.(1552-1554)GAG>CAG	p.E518Q		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	518	LRR 6.					endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		AAATCTGGAAGAGCTGTACCT	0.468													22	37					0	0	0	0	C	90179681	C	C	90179681	3	2	122	1	0	0	0	0	1	0	0	0	9073	943	33	2	1558	2	LRRC8C	1	90179681	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	599946	90179681	159070940	21	21468											
CCDC18	343099	broad.mit.edu	37	chr1	93649049	93649049	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagtttaggggaagagttatCcaggtaagtaagtaaaatca	16	10	12	3	0	1	1	1	0	0	1	2	3	2	2	1	3	0	5	1	3	7	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:93649049C>G	uc001dpq.2	+	2	653	c.485C>G	c.(484-486)TCC>TGC	p.S162C	TMED5_uc001dpn.2_5'Flank|TMED5_uc001dpo.2_5'Flank|TMED5_uc001dpp.2_5'Flank	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	44										ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		GAAGAGTTATCCAGGTAAGTA	0.343													23	28					0	0	0	0	G	93649049	G	G	93649049	3	3	122	1	0	0	0	0	1	0	0	0	2807	855	30	2	491	2	CCDC18	1	93649049	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	3469368	93649049	155601572	22	21469											
S1PR1	1901	broad.mit.edu	37	chr1	101704696	101704696	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaactgacctcggtggtgttCattctcatctgctgctttat	7	16	8	10	1	3	1	2	1	2	0	5	1	3	1	1	2	3	3	1	2	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:101704696C>T	uc001dud.2	+	2	670	c.156C>T	c.(154-156)TTC>TTT	p.F52F	S1PR1_uc009weg.2_Silent_p.F52F	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	52	Helical; Name=1; (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						CGGTGGTGTTCATTCTCATCT	0.438											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	85					0	0	0	0	T	101704696	T	T	101704696	2	4	122	1	0	0	0	0	0	0	0	1	13858	825	29	2		2	S1PR1	1	101704696	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	8055647	101704696	147545925	23	21470											
CELSR2	1952	broad.mit.edu	37	chr1	109811620	109811621	+	Frame_Shift_Del	DEL	TG	-	-																															acagtcattctgcctgagtcTgtcttcagaggtcagtggtg																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:109811620_109811621delTG	uc001dxa.3	+	19	6682_6683	c.6621_6622delTG	c.(6619-6624)TCTGTCfs	p.S2207fs		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2207_2208	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TGCCTGAGTCTGTCTTCAGAGG	0.599													---	---	---								-	109811621	-	-	109811620	7	5	122	1	0	1	0	1	0	0	0	0	3237	1567	55	0	6695	0	CELSR2	1	109811620	Frame_Shift_Del	DEL	TG	TCGA-CR-6472-01A-11D-1870-08	8106924	109811620	139439001	24	21471											
EPS8L3	79574	broad.mit.edu	37	chr1	110294644	110294644	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctctccctggaccacagtCagttcccgtgggttcctagc	5	12	9	15	1	2	0	1	0	1	0	6	1	5	1	4	2	1	2	4	2	1	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:110294644C>T	uc001dyr.1	-	15	1552	c.1407G>A	c.(1405-1407)CTG>CTA	p.L469L	EPS8L3_uc001dys.1_Silent_p.L439L|EPS8L3_uc001dyq.1_Silent_p.L470L|EPS8L3_uc009wfm.1_Silent_p.L406L|EPS8L3_uc009wfn.1_Silent_p.L414L	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	469	SH3.					cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		GGACCACAGTCAGTTCCCGTG	0.592													42	93					0	0	0	0	T	110294644	T	T	110294644	2	4	122	1	0	0	0	0	0	0	0	1	5221	813	29	2		2	EPS8L3	1	110294644	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	483024	110294644	138955977	25	21472											
KCNA2	3737	broad.mit.edu	37	chr1	111146834	111146834	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accatgcatgtcttcattctCatcccggaagatgggcaatg	10	11	9	11	1	3	1	2	0	2	1	5	2	4	2	2	2	1	2	2	2	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:111146834C>T	uc001dzu.2	-	2	1067	c.571G>A	c.(571-573)GAG>AAG	p.E191K	KCNA2_uc009wfv.1_Missense_Mutation_p.E191K|KCNA2_uc009wfw.2_Missense_Mutation_p.E191K	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	191						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		TCTTCATTCTCATCCCGGAAG	0.493													31	54					0	0	0	0	T	111146834	T	T	111146834	3	4	122	1	0	0	0	0	1	0	0	0	8042	835	29	2	932	2	KCNA2	1	111146834	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	852190	111146834	138103787	26	21473											
DDX20	11218	broad.mit.edu	37	chr1	112309284	112309284	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggcggtcttccttcagattGcagactgaagcccaggaaga	11	8	12	10	1	2	4	1	1	1	3	3	5	3	5	2	3	2	1	2	3	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:112309284G>A	uc001ebs.2	+	11	2595	c.2238G>A	c.(2236-2238)TTG>TTA	p.L746L	DDX20_uc010owf.1_Silent_p.L508L|DDX20_uc001ebt.2_Silent_p.L354L	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	746					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCTTCAGATTGCAGACTGAAG	0.473													21	46					0	0	0	0	A	112309284	A	A	112309284	2	1	122	1	0	0	0	0	0	0	0	1	4365	1310	46	4		4	DDX20	1	112309284	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1162450	112309284	136941337	27	21474											
MAGI3	260425	broad.mit.edu	37	chr1	114226508	114226508	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcagctgacaaaaacaaaGagactggaaggttcaaaccg	18	4	11	8	1	1	2	1	1	0	1	1	4	1	3	1	3	3	3	1	3	5	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:114226508G>C	uc001edk.2	+	21	4499	c.4318G>C	c.(4318-4320)GAG>CAG	p.E1440Q	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1465					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAAAACAAAGAGACTGGAAG	0.433													4	14					0	0	0	0	C	114226508	C	C	114226508	3	2	122	1	0	0	0	0	1	0	0	0	9245	943	33	2	4454	2	MAGI3	1	114226508	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1917224	114226508	135024113	28	21475											
PEX11B	8799	broad.mit.edu	37	chr1	145522727	145522727	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcggctgcaagtcctgctCctggctcgagtccttagagg	5	11	12	13	2	0	1	0	0	0	1	5	2	3	1	3	3	2	4	3	3	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:145522727C>A	uc001eny.1	+	4	606	c.588C>A	c.(586-588)CTC>CTA	p.L196L	NBPF10_uc001emp.3_Intron|PEX11B_uc010oyu.1_Silent_p.L182L|ITGA10_uc001enz.1_5'Flank|ITGA10_uc001eoa.2_5'Flank|ITGA10_uc010oyv.1_5'Flank|ITGA10_uc009wiw.2_5'Flank	NM_003846	NP_003837	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	196					peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAGTCCTGCTCCTGGCTCGAG	0.577													34	192					2.26627e-22	2.47051e-22	1	0	A	145522727	A	A	145522727	2	1	122	1	0	0	0	0	0	0	0	1	11793	842	30	2		2	PEX11B	1	145522727	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	31296219	145522727	103727894	29	21476											
GJA8	2703	broad.mit.edu	37	chr1	147381142	147381142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagaagaaggaggaagcaGagaggctgaccacggaggag	16	1	19	5	1	0	4	0	1	0	3	0	11	0	8	1	5	1	2	1	5	3	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:147381142G>A	uc001epu.1	+	2	1123	c.1060G>A	c.(1060-1062)GAG>AAG	p.E354K		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	354	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					GGAGGAAGCAGAGAGGCTGAC	0.632													5	20					0	0	0	0	A	147381142	A	A	147381142	3	1	122	1	0	0	0	0	1	0	0	0	6442	943	33	2	1062	2	GJA8	1	147381142	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1858415	147381142	101869479	30	21477											
FCGR1A	2209	broad.mit.edu	37	chr1	149762936	149762936	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gggatttagaaatctctttgGattctggtcatgagaagaag	12	13	12	4	0	3	3	1	1	2	3	4	6	3	5	0	3	0	0	0	3	4	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:149762936G>C	uc001esp.3	+	6	1038	c.988G>C	c.(988-990)GAT>CAT	p.D330H	HIST2H2BF_uc010pbj.1_Intron|FCGR1A_uc009wlg.2_RNA	NM_000566	NP_000557	P12314	FCGR1_HUMAN	Fc fragment of IgG, high affinity Ia, receptor	330	Cytoplasmic (Potential).|Interaction with EPB41L2.				interferon-gamma-mediated signaling pathway|phagocytosis, engulfment	integral to membrane|plasma membrane	IgG binding|receptor activity|receptor signaling protein activity			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)				Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Methyl aminolevulinate(DB00992)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Porfimer(DB00707)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AATCTCTTTGGATTCTGGTCA	0.383													28	142					0	0	0	0	C	149762936	C	C	149762936	3	2	122	1	0	0	0	0	1	0	0	0	5811	1174	41	2	1010	2	FCGR1A	1	149762936	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2381794	149762936	99487685	31	21478											
HIST2H2AC	8338	broad.mit.edu	37	chr1	149858839	149858839	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcaaagtcaccatcgcccaGggcggcgttttgcctaacat	9	8	11	13	3	1	0	1	0	0	0	2	0	1	0	3	3	2	2	3	3	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:149858839G>T	uc001etd.2	+	1	315	c.315G>T	c.(313-315)CAG>CAT	p.Q105H	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	105					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CCATCGCCCAGGGCGGCGTTT	0.522													41	163					1.68508e-10	1.76948e-10	1	0	T	149858839	T	T	149858839	3	4	122	1	0	0	0	0	1	0	0	0	7217	991	35	4	317	4	HIST2H2AC	1	149858839	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	95903	149858839	99391782	32	21479											
SV2A	9900	broad.mit.edu	37	chr1	149878401	149878401	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgttcacaaacttgtactcGaacaggtctgtgggcaaagg	11	10	11	9	1	2	0	1	0	1	0	3	1	2	0	0	3	3	3	0	3	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:149878401G>C	uc001etg.2	-	11	2177	c.1686C>G	c.(1684-1686)TTC>TTG	p.F562L	SV2A_uc009wlk.2_Missense_Mutation_p.F14L|SV2A_uc001eth.2_Missense_Mutation_p.F562L	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	562	Extracellular (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	ACTTGTACTCGAACAGGTCTG	0.537													16	46					0	0	0	0	C	149878401	C	C	149878401	3	2	122	1	0	0	0	0	1	0	0	0	15483	1049	37	3	554	3	SV2A	1	149878401	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	19562	149878401	99372220	33	21480											
SNX27	81609	broad.mit.edu	37	chr1	151630748	151630748	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagggaggcagctgtgttCtaagcggtaccgggagtttg	7	9	18	7	2	1	0	0	0	1	0	1	2	1	2	1	5	3	6	1	5	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:151630748C>G	uc001eyn.1	+	3	597	c.581C>G	c.(580-582)TCT>TGT	p.S194C	SNX27_uc001eyo.2_Missense_Mutation_p.S101C|SNX27_uc001eyp.2_Missense_Mutation_p.S8C	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	194	PX.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			CAGCTGTGTTCTAAGCGGTAC	0.408													61	252					0	0	0	0	G	151630748	G	G	151630748	3	3	122	1	0	0	0	0	1	0	0	0	14961	913	32	2	591	2	SNX27	1	151630748	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1752347	151630748	97619873	34	21481											
FLG	2312	broad.mit.edu	37	chr1	152282183	152282183	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgactgtgtgtctgactcttCtgagtgtccctcgctgtcac	4	15	10	12	1	4	3	1	3	3	0	6	3	5	3	1	0	0	1	1	0	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:152282183C>T	uc001ezu.1	-	3	5215	c.5179G>A	c.(5179-5181)GAA>AAA	p.E1727K		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1727	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGACTCTTCTGAGTGTCCC	0.597									Ichthyosis				151	465					0	0	0	0	T	152282183	T	T	152282183	3	4	122	1	0	0	0	0	1	0	0	0	5954	922	32	2	7010	2	FLG	1	152282183	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	651435	152282183	96968438	35	21482											
LCE2C	353140	broad.mit.edu	37	chr1	152648745	152648745	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtctcttccaccggcgccGgcaccagagccccgactgct	5	6	10	20	5	1	1	0	0	1	1	3	2	2	1	7	2	2	2	7	2	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:152648745G>T	uc001fah.2	+	2	309	c.254G>T	c.(253-255)CGG>CTG	p.R85L		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	85	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACCGGCGCCGGCACCAGAGC	0.677													5	112					0.00116845	0.00118541	1	0	T	152648745	T	T	152648745	3	4	122	1	0	0	0	0	1	0	0	0	8707	1116	39	3	256	3	LCE2C	1	152648745	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	366562	152648745	96601876	36	21483											
CRTC2	200186	broad.mit.edu	37	chr1	153925047	153925047	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acccggtggcctcctcctacCttcttagcatcccatggctt	5	12	7	17	1	1	0	0	0	1	0	4	0	4	0	6	3	2	2	6	3	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:153925047C>G	uc010ped.1	-	8	772	c.702G>C	c.(700-702)AAG>AAC	p.K234N	CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_5'UTR	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	234					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTCCTCCTACCTTCTTAGCAT	0.522													9	521					0	0	0	0	G	153925047	G	G	153925047	3	3	122	1	0	0	0	0	1	0	0	0	3915	695	24	4	1407	4	CRTC2	1	153925047	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1276302	153925047	95325574	37	21484											
SSR2	6746	broad.mit.edu	37	chr1	155984754	155984754	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtttgggcaactcaccaCaacgggcccatcctcctggg	8	7	12	14	1	1	0	1	0	0	0	3	0	3	0	4	4	2	2	4	4	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:155984754C>A	uc001fmx.2	-	4	441	c.361G>T	c.(361-363)GTG>TTG	p.V121L	SSR2_uc001fmv.2_5'Flank|SSR2_uc001fmw.2_RNA|SSR2_uc001fmy.2_RNA|SSR2_uc010pgv.1_Intron|SSR2_uc010pgw.1_Missense_Mutation_p.V140L	NM_003145	NP_003136	P43308	SSRB_HUMAN	signal sequence receptor, beta precursor	121	Lumenal (Potential).				cotranslational protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CAACTCACCACAACGGGCCCA	0.423													8	39					1.06961e-07	1.10656e-07	1	0	A	155984754	A	A	155984754	3	1	122	1	0	0	0	0	1	0	0	0	15257	478	17	4	202	4	SSR2	1	155984754	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2059707	155984754	93265867	38	21485											
COPA	1314	broad.mit.edu	37	chr1	160309718	160309718	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccttaatcttatagtcatctCctccagagacgaacagtggc	11	11	7	12	1	3	1	1	0	2	1	5	3	4	1	3	1	1	0	3	1	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:160309718C>G	uc009wti.2	-	3	603	c.209G>C	c.(208-210)GGA>GCA	p.G70A	COPA_uc001fvv.3_Missense_Mutation_p.G70A|COPA_uc009wtj.1_Intron	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	70	WD 2.				COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATAGTCATCTCCTCCAGAGAC	0.458													63	219					0	0	0	0	G	160309718	G	G	160309718	3	3	122	1	0	0	0	0	1	0	0	0	3742	855	30	2	3616	2	COPA	1	160309718	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	4324964	160309718	88940903	39	21486											
NDUFS2	4720	broad.mit.edu	37	chr1	161172237	161172237	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcccaggtgctgcggcctgGggctggagtccgattgccga	4	7	18	12	3	0	0	0	0	0	0	1	3	1	1	4	6	3	2	4	6	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:161172237G>C	uc001fyv.2	+	2	510	c.62G>C	c.(61-63)GGG>GCG	p.G21A	NDUFS2_uc010pki.1_5'UTR|NDUFS2_uc001fyw.2_Missense_Mutation_p.G21A|NDUFS2_uc010pkj.1_5'UTR|NDUFS2_uc001fyx.2_Missense_Mutation_p.G21A|NDUFS2_uc001fyy.1_5'Flank	NM_004550	NP_004541	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2	21					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			skin(1)	1	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	CTGCGGCCTGGGGCTGGAGTC	0.652													3	31					0	0	0	0	C	161172237	C	C	161172237	3	2	122	1	0	0	0	0	1	0	0	0	10346	1232	43	4	64	4	NDUFS2	1	161172237	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	862519	161172237	88078384	40	21487											
DDR2	4921	broad.mit.edu	37	chr1	162745470	162745470	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttaaggagataaagatcAtgtctcggctcaaggaccca	13	10	9	9	1	4	2	2	0	2	2	5	4	4	3	1	3	0	1	1	3	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:162745470A>G	uc001gcf.2	+	16	2350	c.1885A>G	c.(1885-1887)ATG>GTG	p.M629V	DDR2_uc001gcg.2_Missense_Mutation_p.M629V	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	629	Cytoplasmic (Potential).|Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GATAAAGATCATGTCTCGGCT	0.413													12	173					0	0	0	0	G	162745470	G	G	162745470	3	3	122	1	0	0	0	0	1	0	0	0	4354	217	8	5	1935	5	DDR2	1	162745470	Missense_Mutation	SNP	A	TCGA-CR-6472-01A-11D-1870-08	1573233	162745470	86505151	41	21488											
DCAF6	55827	broad.mit.edu	37	chr1	168014240	168014240	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttccagaagaatctgcttCatctgaaaaagccaaggaac	15	8	9	9	0	3	3	1	1	2	2	4	4	4	4	2	2	3	2	2	2	6	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:168014240C>T	uc001gew.2	+	14	2044	c.1802C>T	c.(1801-1803)TCA>TTA	p.S601L	DCAF6_uc001gev.2_Missense_Mutation_p.S621L|DCAF6_uc001gex.2_Missense_Mutation_p.S678L|DCAF6_uc010plk.1_Missense_Mutation_p.S647L|DCAF6_uc001gey.2_Missense_Mutation_p.S474L|DCAF6_uc001gez.2_5'UTR	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	601					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GAATCTGCTTCATCTGAAAAA	0.433													43	161					0	0	0	0	T	168014240	T	T	168014240	3	4	122	1	0	0	0	0	1	0	0	0	4291	838	29	2	1920	2	DCAF6	1	168014240	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	5268770	168014240	81236381	42	21489											
BAT2L2	23215	broad.mit.edu	37	chr1	171530231	171530231	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	taacatcgtttggatcagctCcttcatcagaggtaagaata	13	12	8	8	1	3	2	3	0	0	2	5	3	4	3	1	2	2	3	1	2	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:171530231C>G	uc010pmg.1	+	20	6366	c.6100C>G	c.(6100-6102)CCT>GCT	p.P2034A	BAT2L2_uc010pmh.1_Missense_Mutation_p.P1011A|BAT2L2_uc010pmi.1_5'UTR	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	2034							protein C-terminus binding				0						TGGATCAGCTCCTTCATCAGA	0.363													95	269					0	0	0	0	G	171530231	G	G	171530231	3	3	122	1	0	0	0	0	1	0	0	0	1323	855	30	2	6174	2	BAT2L2	1	171530231	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	3515991	171530231	77720390	43	21490											
BAT2L2	23215	broad.mit.edu	37	chr1	171560972	171560972	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaggcgatcaaaaccgaaGaaacaaaatcttaaaggcta	19	6	7	9	2	3	1	2	0	1	1	3	3	3	1	1	2	2	1	1	2	9	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:171560972G>T	uc010pmg.1	+	34	8706	c.8440G>T	c.(8440-8442)GAA>TAA	p.E2814*	BAT2L2_uc010pmh.1_Nonsense_Mutation_p.E1726*|BAT2L2_uc010pmi.1_Nonsense_Mutation_p.E730*|BAT2L2_uc010pmj.1_Nonsense_Mutation_p.E346*	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							protein C-terminus binding				0						CAAAACCGAAGAAACAAAATC	0.478													38	155					6.5261e-18	7.02897e-18	1	0	T	171560972	T	T	171560972	4	4	122	1	0	0	0	0	0	1	0	0	1323	943	33	2	8462	2	BAT2L2	1	171560972	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	30741	171560972	77689649	44	21491											
SLC9A11	284525	broad.mit.edu	37	chr1	173545823	173545823	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtaattacaagttcgatcttCggtttaaaagttaaagaatc	15	14	7	5	2	1	1	0	0	1	1	4	2	1	1	0	1	1	4	0	1	8	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:173545823C>T	uc001giz.2	-	8	1302	c.879G>A	c.(877-879)CCG>CCA	p.P293P	SLC9A11_uc009wwe.2_5'UTR|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	293					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity	p.P293P(1)		ovary(2)	2						GTTCGATCTTCGGTTTAAAAG	0.403													12	34					0	0	0	0	T	173545823	T	T	173545823	2	4	122	1	0	0	0	0	0	0	0	1	14775	871	31	1		1	SLC9A11	1	173545823	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1984851	173545823	75704798	45	21492											
RABGAP1L	9910	broad.mit.edu	37	chr1	174363181	174363181	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggctgtctactctggtgaaGagtggtgtccctgaagcatt	7	12	14	8	0	2	3	0	2	2	1	3	3	3	3	1	3	2	2	1	3	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:174363181G>C	uc001gjx.2	+	13	1803	c.1608G>C	c.(1606-1608)AAG>AAC	p.K536N	RABGAP1L_uc009wwq.1_Missense_Mutation_p.K548N|RABGAP1L_uc001gjw.2_Missense_Mutation_p.K499N|RABGAP1L_uc001gjy.2_Missense_Mutation_p.K204N|RABGAP1L_uc001gjz.2_Missense_Mutation_p.K183N	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	536					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						CTCTGGTGAAGAGTGGTGTCC	0.473													45	123					0	0	0	0	C	174363181	C	C	174363181	3	2	122	1	0	0	0	0	1	0	0	0	13030	933	33	2	1654	2	RABGAP1L	1	174363181	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	817358	174363181	74887440	46	21493											
TNR	7143	broad.mit.edu	37	chr1	175360470	175360470	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggctgcgggcctgttctttCagagccaccacattgacaat	8	10	11	12	1	2	2	1	1	1	1	2	2	2	2	3	2	2	2	3	2	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:175360470C>G	uc001gkp.1	-	5	1542	c.1461G>C	c.(1459-1461)CTG>CTC	p.L487L	TNR_uc009wwu.1_Silent_p.L487L	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	487	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CCTGTTCTTTCAGAGCCACCA	0.557													31	67					0	0	0	0	G	175360470	G	G	175360470	2	3	122	1	0	0	0	0	0	0	0	1	16404	813	29	2		2	TNR	1	175360470	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	997289	175360470	73890151	47	21494											
ASTN1	460	broad.mit.edu	37	chr1	176983947	176983947	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccctggtttgtcccccattcGttccgaatgcaaaggtgctt	6	13	9	13	2	0	0	0	0	0	0	3	1	2	0	4	2	2	4	4	2	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:176983947G>A	uc001glc.2	-	8	1715	c.1503C>T	c.(1501-1503)AAC>AAT	p.N501N	ASTN1_uc001glb.1_Silent_p.N501N|ASTN1_uc001gld.1_Silent_p.N501N|ASTN1_uc009wwx.1_Silent_p.N501N|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	509					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCCCCCATTCGTTCCGAATGC	0.493													179	419					0	0	0	0	A	176983947	A	A	176983947	2	1	122	1	0	0	0	0	0	0	0	1	1066	1136	40	1		1	ASTN1	1	176983947	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1623477	176983947	72266674	48	21495											
RASAL2	9462	broad.mit.edu	37	chr1	178389654	178389654	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttccttctagggattcttCagcaagcgcctgaaaggctc	8	12	9	12	1	3	1	1	1	2	0	5	2	4	2	2	2	2	2	2	2	3	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:178389654C>G	uc001glr.2	+	3	254	c.129C>G	c.(127-129)TTC>TTG	p.F43L	RASAL2_uc009wxb.2_Missense_Mutation_p.F191L|RASAL2_uc001glq.2_Missense_Mutation_p.F191L	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	43	PH.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						AGGGATTCTTCAGCAAGCGCC	0.468													12	51					0	0	0	0	G	178389654	G	G	178389654	3	3	122	1	0	0	0	0	1	0	0	0	13129	825	29	2	608	2	RASAL2	1	178389654	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1405707	178389654	70860967	49	21496											
CEP350	9857	broad.mit.edu	37	chr1	179972362	179972362	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctgatgggaaagtgtggcagGaggctgagtttcaaaacatg	12	9	15	5	0	1	2	1	2	0	0	1	4	1	4	0	4	1	3	0	4	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:179972362G>C	uc001gnt.2	+	7	1455	c.1072G>C	c.(1072-1074)GAG>CAG	p.E358Q	CEP350_uc009wxl.2_Missense_Mutation_p.E357Q|CEP350_uc001gnu.2_Missense_Mutation_p.E192Q	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	358						centrosome|nucleus|spindle				ovary(4)	4						AGTGTGGCAGGAGGCTGAGTT	0.378													14	45					0	0	0	0	C	179972362	C	C	179972362	3	2	122	1	0	0	0	0	1	0	0	0	3269	1175	41	2	1094	2	CEP350	1	179972362	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1582708	179972362	69278259	50	21497											
LHX4	89884	broad.mit.edu	37	chr1	180199673	180199673	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcgctccgagatgatgcaGagtgcgactgtccccgcgga	7	9	13	12	5	0	3	0	1	0	2	3	6	2	4	3	1	2	2	3	1	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:180199673G>A	uc001goe.1	+	1	232	c.9G>A	c.(7-9)CAG>CAA	p.Q3Q		NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	3						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AGATGATGCAGAGTGCGACTG	0.522													13	46					0	0	0	0	A	180199673	A	A	180199673	2	1	122	1	0	0	0	0	0	0	0	1	8814	933	33	2		2	LHX4	1	180199673	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	227311	180199673	69050948	51	21498											
XPR1	9213	broad.mit.edu	37	chr1	180843068	180843068	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctactgtctttgccccacttGaggttttccggtaagcaaac	8	13	8	12	1	1	1	0	1	1	0	2	1	2	1	3	2	4	3	3	2	3	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:180843068G>C	uc001goi.2	+	13	1990	c.1798G>C	c.(1798-1800)GAG>CAG	p.E600Q	XPR1_uc009wxn.2_Missense_Mutation_p.E535Q	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	600	EXS.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						TGCCCCACTTGAGGTTTTCCG	0.363													22	40					0	0	0	0	C	180843068	C	C	180843068	3	2	122	1	0	0	0	0	1	0	0	0	17519	1291	45	2	1848	2	XPR1	1	180843068	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	643395	180843068	68407553	52	21499											
CACNA1E	777	broad.mit.edu	37	chr1	181689972	181689972	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttttgataccttccctgcagCcatcatgactgtgttccagg	7	14	8	12	0	1	2	1	2	0	0	3	2	3	2	4	1	3	2	4	1	1	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:181689972C>G	uc001gow.2	+	15	2102	c.1937C>G	c.(1936-1938)GCC>GGC	p.A646G	CACNA1E_uc009wxs.2_Missense_Mutation_p.A553G	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	646	Extracellular (Potential).|II.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TTCCCTGCAGCCATCATGACT	0.433													6	32					0	0	0	0	G	181689972	G	G	181689972	3	3	122	1	0	0	0	0	1	0	0	0	2554	739	26	4	1995	4	CACNA1E	1	181689972	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	846904	181689972	67560649	53	21500											
RNASEL	6041	broad.mit.edu	37	chr1	182555377	182555377	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacatctgcccccatctcatCaaggagaatcttcaagacct	12	10	5	14	0	5	2	3	0	3	2	6	3	5	2	3	1	2	0	3	1	4	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:182555377C>G	uc001gpj.1	-	1	732	c.565G>C	c.(565-567)GAT>CAT	p.D189H	RNASEL_uc009wxz.1_Missense_Mutation_p.D189H|RNASEL_uc001gpk.2_Missense_Mutation_p.D189H|RNASEL_uc009wya.1_Missense_Mutation_p.D189H	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	189	ANK 5.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						CCCATCTCATCAAGGAGAATC	0.502									Hereditary_Prostate_Cancer				32	93					0	0	0	0	G	182555377	G	G	182555377	3	3	122	1	0	0	0	0	1	0	0	0	13481	826	29	2	1684	2	RNASEL	1	182555377	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	865405	182555377	66695244	54	21501											
LAMC2	3918	broad.mit.edu	37	chr1	183196670	183196670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagattgttattcaggggatGagaatcctgacattgagtgt	11	13	13	4	0	1	4	1	3	0	2	2	7	2	5	1	2	0	1	1	2	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:183196670G>A	uc001gqa.2	+	10	1620	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	LAMC2_uc001gpz.3_Missense_Mutation_p.E436K|LAMC2_uc010poa.1_Missense_Mutation_p.E136K	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	436	Laminin EGF-like 5.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						TTCAGGGGATGAGAATCCTGA	0.522													55	262					0	0	0	0	A	183196670	A	A	183196670	3	1	122	1	0	0	0	0	1	0	0	0	8655	1291	45	2	1344	2	LAMC2	1	183196670	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	641293	183196670	66053951	55	21502											
GLT25D2	23127	broad.mit.edu	37	chr1	183938448	183938448	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaatgatgtcatcaaaggTccaggtgtagtcctggtgtg	10	11	13	7	0	2	1	2	1	0	0	4	2	4	1	2	3	0	1	2	3	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:183938448T>C	uc001gqr.2	-	5	1159	c.787A>G	c.(787-789)ACC>GCC	p.T263A	GLT25D2_uc010poj.1_Missense_Mutation_p.T263A|GLT25D2_uc001gqs.2_Missense_Mutation_p.T143A	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	263					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						TCATCAAAGGTCCAGGTGTAG	0.527													27	94					0	0	0	0	C	183938448	C	C	183938448	3	2	122	1	0	0	0	0	1	0	0	0	6504	1667	58	5	1125	5	GLT25D2	1	183938448	Missense_Mutation	SNP	T	TCGA-CR-6472-01A-11D-1870-08	741778	183938448	65312173	56	21503											
ASPM	259266	broad.mit.edu	37	chr1	197070880	197070880	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagcatgtttccaagtctGaaatgtaatatatgttctgt	12	16	8	5	0	2	2	0	2	2	0	3	2	3	2	1	0	1	4	1	0	6	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:197070880G>A	uc001gtu.2	-	18	7758	c.7501C>T	c.(7501-7503)CAG>TAG	p.Q2501*	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Nonsense_Mutation_p.Q349*	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2501					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTCCAAGTCTGAAATGTAATA	0.348													44	123					0	0	0	0	A	197070880	A	A	197070880	4	1	122	1	0	0	0	0	0	1	0	0	1058	1299	45	2	2976	2	ASPM	1	197070880	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	13132432	197070880	52179741	57	21504											
NR5A2	2494	broad.mit.edu	37	chr1	200143123	200143123	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaaaacttccagctggtaGaaggtgtccaggaacaagtc	13	9	11	8	0	0	2	0	1	0	1	3	3	2	3	2	3	3	2	2	3	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:200143123G>C	uc001gvb.2	+	8	1617	c.1411G>C	c.(1411-1413)GAA>CAA	p.E471Q	NR5A2_uc001gvc.2_Missense_Mutation_p.E425Q|NR5A2_uc009wzh.2_Missense_Mutation_p.E431Q|NR5A2_uc010pph.1_Missense_Mutation_p.E399Q	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	471					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					CCAGCTGGTAGAAGGTGTCCA	0.393													3	15					0	0	0	0	C	200143123	C	C	200143123	3	2	122	1	0	0	0	0	1	0	0	0	10690	943	33	2	1441	2	NR5A2	1	200143123	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3072243	200143123	49107498	58	21505											
LGR6	59352	broad.mit.edu	37	chr1	202288024	202288024	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctggagaagagctcctgtGattctacccaggccctggta	9	9	12	11	0	1	3	0	1	1	2	2	4	2	3	3	3	3	3	3	3	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:202288024G>A	uc001gxu.2	+	18	2593	c.2593G>A	c.(2593-2595)GAT>AAT	p.D865N	LGR6_uc001gxv.2_Missense_Mutation_p.D813N|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.D726N	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	865	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						GAGCTCCTGTGATTCTACCCA	0.652													33	97					0	0	0	0	A	202288024	A	A	202288024	3	1	122	1	0	0	0	0	1	0	0	0	8799	1290	45	2	2810	2	LGR6	1	202288024	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2144901	202288024	46962597	59	21506											
MYOG	4656	broad.mit.edu	37	chr1	203054939	203054939	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtccccagccccttgtcctCaaggggccctggggcctcgg	3	7	14	17	1	1	0	1	0	0	0	4	0	3	0	7	6	1	0	7	6	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:203054939C>T	uc001gzd.2	-	1	439	c.151G>A	c.(151-153)GAG>AAG	p.E51K		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	51					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2						CCCTTGTCCTCAAGGGGCCCT	0.672													40	77					0	0	0	0	T	203054939	T	T	203054939	3	4	122	1	0	0	0	0	1	0	0	0	10143	835	29	2	535	2	MYOG	1	203054939	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	766915	203054939	46195682	60	21507											
FMOD	2331	broad.mit.edu	37	chr1	203316468	203316468	+	Missense_Mutation	SNP	C	G	G																															gttctccaggttggtgttgaCtggggggatcttctgcagct																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:203316468C>G	uc001gzr.2	-	2	1067	c.931G>C	c.(931-933)GTC>CTC	p.V311L	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	311	LRR 9.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			TTGGTGTTGACTGGGGGGATC	0.527													41	133					0	0	0	0	G	203316468	G	G	203316468	3	3	122	1	0	0	0	0	1	0	0	0	5991	565	20	4	207	4	FMOD	1	203316468	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	261529	203316468	45934153	61	21508	42	2									
FMOD	2331	broad.mit.edu	37	chr1	203316478	203316478	+	Missense_Mutation	SNP	C	G	G																															ttggtgttgactggggggatCttctgcagctggttgtagga																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:203316478C>G	uc001gzr.2	-	2	1057	c.921G>C	c.(919-921)AAG>AAC	p.K307N	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	307	LRR 9.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			CTGGGGGGATCTTCTGCAGCT	0.542													43	132					0	0	0	0	G	203316478	G	G	203316478	3	3	122	1	0	0	0	0	1	0	0	0	5991	912	32	2	217	2	FMOD	1	203316478	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	10	203316478	45934143	62	21509	42	2									
CNTN2	6900	broad.mit.edu	37	chr1	205027723	205027723	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaattctccaaggaggagcGagacccagtgaaagctcatg	13	6	13	9	1	2	2	1	1	1	1	3	6	2	5	2	3	2	1	2	3	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:205027723G>A	uc001hbr.2	+	5	688	c.419G>A	c.(418-420)CGA>CAA	p.R140Q	CNTN2_uc001hbq.1_Missense_Mutation_p.R31Q|CNTN2_uc009xbi.2_Missense_Mutation_p.R31Q|CNTN2_uc001hbs.2_5'Flank	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	140	Ig-like C2-type 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AAGGAGGAGCGAGACCCAGTG	0.622													28	18					0	0	0	0	A	205027723	A	A	205027723	3	1	122	1	0	0	0	0	1	0	0	0	3656	1058	37	1	433	1	CNTN2	1	205027723	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1711245	205027723	44222898	63	21510											
CDK18	5129	broad.mit.edu	37	chr1	205495256	205495256	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaccttgtggccctgaaaGagatccggctggagcacgag	11	6	14	10	2	0	3	0	1	0	2	1	6	1	4	3	3	2	2	3	3	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:205495256G>C	uc001hcr.2	+	6	829	c.610G>C	c.(610-612)GAG>CAG	p.E204Q	CDK18_uc010pri.1_Missense_Mutation_p.R194T|CDK18_uc001hcp.2_Missense_Mutation_p.E174Q|CDK18_uc001hcq.2_Missense_Mutation_p.E174Q|CDK18_uc010prj.1_Missense_Mutation_p.E85Q|CDK18_uc001hcs.2_Missense_Mutation_p.E85Q|CDK18_uc009xbm.1_Missense_Mutation_p.E85Q	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	172	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						GGCCCTGAAAGAGATCCGGCT	0.647													10	28					0	0	0	0	C	205495256	C	C	205495256	3	2	122	1	0	0	0	0	1	0	0	0	3149	943	33	2	628	2	CDK18	1	205495256	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	467533	205495256	43755365	64	21511											
IL10	3586	broad.mit.edu	37	chr1	206942023	206942023	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtaggcttctatgtagttGatgaagatgtcaaactcact	12	14	9	6	0	3	3	2	2	1	1	3	3	3	3	0	1	1	4	0	1	5	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:206942023G>A	uc001hen.1	-	5	554	c.495C>T	c.(493-495)ATC>ATT	p.I165I		NM_000572	NP_000563	P22301	IL10_HUMAN	interleukin 10 precursor	165					anti-apoptosis|B cell differentiation|B cell proliferation|cytoplasmic sequestering of NF-kappaB|inflammatory response|leukocyte chemotaxis|negative regulation of B cell proliferation|negative regulation of cytokine secretion involved in immune response|negative regulation of interferon-alpha biosynthetic process|negative regulation of interleukin-6 production|negative regulation of membrane protein ectodomain proteolysis|negative regulation of MHC class II biosynthetic process|negative regulation of T cell proliferation|positive regulation of B cell apoptosis|positive regulation of cytokine secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|receptor biosynthetic process|regulation of isotype switching|response to glucocorticoid stimulus|type 2 immune response	extracellular space	cytokine activity|growth factor activity|interleukin-10 receptor binding				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			CTATGTAGTTGATGAAGATGT	0.408													33	31					0	0	0	0	A	206942023	A	A	206942023	2	1	122	1	0	0	0	0	0	0	0	1	7658	1280	45	2		2	IL10	1	206942023	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1446767	206942023	42308598	65	21512											
CD46	4179	broad.mit.edu	37	chr1	207925591	207925591	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccgccgcgagtgtccctttCcttcctggcgctttcctggg	1	12	12	16	4	0	0	0	0	0	0	4	1	4	0	6	2	0	1	6	2	0	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:207925591C>T	uc001hgc.2	+	1	190	c.34C>T	c.(34-36)CCT>TCT	p.P12S	CD46_uc001hgd.2_Missense_Mutation_p.P12S|CD46_uc001hge.2_Missense_Mutation_p.P12S|CD46_uc001hgf.2_Missense_Mutation_p.P12S|CD46_uc001hgg.2_Missense_Mutation_p.P12S|CD46_uc001hgh.2_Missense_Mutation_p.P12S|CD46_uc001hgi.2_Missense_Mutation_p.P12S|CD46_uc001hgj.2_Missense_Mutation_p.P12S|CD46_uc001hgk.2_Missense_Mutation_p.P12S|CD46_uc001hgl.2_Missense_Mutation_p.P12S|CD46_uc001hgm.2_Missense_Mutation_p.P12S|CD46_uc001hgn.2_Missense_Mutation_p.P12S|CD46_uc001hgo.2_Missense_Mutation_p.P12S|CD46_uc001hgp.2_Missense_Mutation_p.P12S	NM_002389	NP_002380	P15529	MCP_HUMAN	CD46 antigen, complement regulatory protein	12					complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			large_intestine(2)|lung(1)|central_nervous_system(1)	4						GTGTCCCTTTCCTTCCTGGCG	0.667													106	311					0	0	0	0	T	207925591	T	T	207925591	3	4	122	1	0	0	0	0	1	0	0	0	3033	855	30	2	36	2	CD46	1	207925591	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	983568	207925591	41325030	66	21513											
INTS7	25896	broad.mit.edu	37	chr1	212161241	212161241	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttacctggaactatactGaagtaatgtttgatggcgat	11	14	9	7	1	0	2	0	2	0	0	1	4	1	3	2	2	3	2	2	2	6	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:212161241G>T	uc001hiw.1	-	8	1089	c.984C>A	c.(982-984)TTC>TTA	p.F328L	INTS7_uc009xdb.1_Missense_Mutation_p.F328L|INTS7_uc001hix.1_Missense_Mutation_p.F204L|INTS7_uc001hiy.1_Missense_Mutation_p.F328L|INTS7_uc010pta.1_Missense_Mutation_p.F279L	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	328					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		GAACTATACTGAAGTAATGTT	0.388													18	62					2.35188e-11	2.47795e-11	1	0	T	212161241	T	T	212161241	3	4	122	1	0	0	0	0	1	0	0	0	7822	1281	45	2	1956	2	INTS7	1	212161241	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4235650	212161241	37089380	67	21514											
NSL1	25936	broad.mit.edu	37	chr1	212964964	212964964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgcacagttgtagcatttCggtcacagcccgcttcgagg	7	9	12	13	4	1	0	1	0	0	0	3	1	1	0	2	2	2	5	2	2	1	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:212964964C>T	uc001hjn.2	-	1	176	c.142G>A	c.(142-144)GAA>AAA	p.E48K	NSL1_uc001hjm.2_Missense_Mutation_p.E48K|NSL1_uc010pti.1_Missense_Mutation_p.E48K|TATDN3_uc001hjo.2_5'Flank|TATDN3_uc010ptj.1_5'Flank|TATDN3_uc010ptk.1_5'Flank|TATDN3_uc001hjp.2_5'Flank|TATDN3_uc010ptl.1_5'Flank	NM_015471	NP_056286	Q96IY1	NSL1_HUMAN	NSL1, MIND kinetochore complex component isoform	48					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00597)|all cancers(67;0.00893)|GBM - Glioblastoma multiforme(131;0.0514)|Epithelial(68;0.102)		TGTAGCATTTCGGTCACAGCC	0.652													41	140					0	0	0	0	T	212964964	T	T	212964964	3	4	122	1	0	0	0	0	1	0	0	0	10727	893	31	1	816	1	NSL1	1	212964964	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	803723	212964964	36285657	68	21515											
MARK1	4139	broad.mit.edu	37	chr1	220809219	220809219	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatcatataccaaaagacctCaggctaacagtgtggaaagt	16	9	8	8	0	2	1	2	0	0	1	2	2	2	2	2	2	2	1	2	2	7	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:220809219C>G	uc001hmn.3	+	13	1918	c.1321C>G	c.(1321-1323)CAG>GAG	p.Q441E	MARK1_uc009xdw.2_Missense_Mutation_p.Q441E|MARK1_uc010pun.1_Missense_Mutation_p.Q441E|MARK1_uc001hmm.3_Missense_Mutation_p.Q419E	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	441					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		CAAAAGACCTCAGGCTAACAG	0.408													30	76					0	0	0	0	G	220809219	G	G	220809219	3	3	122	1	0	0	0	0	1	0	0	0	9365	827	29	2	1371	2	MARK1	1	220809219	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	7844255	220809219	28441402	69	21516											
MIA3	375056	broad.mit.edu	37	chr1	222802603	222802603	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agataaggctctctgagggaGaagccaaagaggactccttg	13	7	13	8	0	1	4	0	1	1	3	3	6	2	5	2	3	1	1	2	3	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:222802603G>A	uc001hnl.2	+	4	2050	c.2041G>A	c.(2041-2043)GAA>AAA	p.E681K	MIA3_uc009xea.1_Missense_Mutation_p.E517K	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	681	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		CTCTGAGGGAGAAGCCAAAGA	0.498													33	112					0	0	0	0	A	222802603	A	A	222802603	3	1	122	1	0	0	0	0	1	0	0	0	9618	943	33	2	2055	2	MIA3	1	222802603	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1993384	222802603	26448018	70	21517											
SUSD4	55061	broad.mit.edu	37	chr1	223438081	223438081	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaagcagcgataggagatCacagtccccaccgggaagga	14	3	14	10	2	1	1	1	0	0	1	2	6	2	4	3	4	2	1	3	4	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:223438081C>T	uc001hnx.2	-	4	1249	c.615G>A	c.(613-615)GTG>GTA	p.V205V	SUSD4_uc001hny.3_Silent_p.V205V|SUSD4_uc010puw.1_Silent_p.V45V|SUSD4_uc001hnz.2_Silent_p.V205V|SUSD4_uc010pux.1_Silent_p.V134V	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	205	Sushi 3.|Extracellular (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)		GATAGGAGATCACAGTCCCCA	0.512													46	117					0	0	0	0	T	223438081	T	T	223438081	2	4	122	1	0	0	0	0	0	0	0	1	15476	813	29	2		2	SUSD4	1	223438081	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	635478	223438081	25812540	71	21518											
SIPA1L2	57568	broad.mit.edu	37	chr1	232649840	232649841	+	Frame_Shift_Del	DEL	TC	-	-																															cctgtcgccttcccctccagTctcatttctaaagtaaggac																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:232649840_232649841delTC	uc001hvg.2	-	1	1403_1404	c.1245_1246delGA	c.(1243-1248)GAGACTfs	p.E415fs		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	415_416					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TCCCCTCCAGTCTCATTTCTAA	0.52													---	---	---								-	232649841	-	-	232649840	7	5	122	1	0	1	0	1	0	0	0	0	14395	1667	58	0	4006	0	SIPA1L2	1	232649840	Frame_Shift_Del	DEL	TC	TCGA-CR-6472-01A-11D-1870-08	9211759	232649840	16600781	72	21519											
TARBP1	6894	broad.mit.edu	37	chr1	234546228	234546228	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtaataatgtctaaatgtGataaaactgctaaaaacgta	19	11	7	4	1	1	1	0	1	1	0	1	2	1	1	0	0	3	3	0	0	10	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:234546228G>C	uc001hwd.2	-	23	3755	c.3755C>G	c.(3754-3756)TCA>TGA	p.S1252*		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	1252					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			GTCTAAATGTGATAAAACTGC	0.259													10	92					0	0	0	0	C	234546228	C	C	234546228	4	2	122	1	0	0	0	0	0	1	0	0	15621	1294	45	2	1142	2	TARBP1	1	234546228	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1896388	234546228	14704393	73	21520											
ERO1LB	56605	broad.mit.edu	37	chr1	236399689	236399689	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacatactgagcagctggaGatctctcatctgaacaagaa	14	9	8	10	0	3	4	1	2	2	2	4	5	3	4	0	1	5	2	0	1	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:236399689G>T	uc001hxt.2	-	7	771	c.515C>A	c.(514-516)TCT>TAT	p.S172Y	ERO1LB_uc010pxt.1_3'UTR	NM_019891	NP_063944	Q86YB8	ERO1B_HUMAN	endoplasmic reticulum oxidoreductin 1-Lbeta	172					electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding				0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			AGCAGCTGGAGATCTCTCATC	0.403													61	144					7.91745e-34	8.75233e-34	1	0	T	236399689	T	T	236399689	3	4	122	1	0	0	0	0	1	0	0	0	5264	942	33	2	928	2	ERO1LB	1	236399689	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1853461	236399689	12850932	74	21521											
OR2W5	441932	broad.mit.edu	37	chr1	247655066	247655066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcctcctggtgccgctctcCctcatcctcatctcctatgg	3	13	6	19	1	4	0	2	0	2	0	9	0	7	0	6	2	1	1	6	2	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:247655066C>T	uc001icz.1	+	1	637	c.637C>T	c.(637-639)CCT>TCT	p.P213S		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TGCCGCTCTCCCTCATCCTCA	0.562													10	150					0	0	0	0	T	247655066	T	T	247655066	3	4	122	1	0	0	0	0	1	0	0	0	11088	623	22	4	639	4	OR2W5	1	247655066	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	11255377	247655066	1595555	75	21522											
OR2G2	81470	broad.mit.edu	37	chr1	247751564	247751565	+	5'Flank	INS	-	T	T																															aagcatttaacatacaatacINSttttttgggtaggcaggtga																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:247751564_247751565insT	uc010pyy.1	+							NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ACATACAATACTTTTTTGGGTA	0.356													---	---	---								T	247751565	T	T	247751564	6	5	122	0	1	1	1	0	0	0	0	0	11052	580	20	0		0	OR2G2	1	247751564	5'Flank	INS	-	TCGA-CR-6472-01A-11D-1870-08	96498	247751564	1499057	76	21523											
OR2G2	81470	broad.mit.edu	37	chr1	247751981	247751981	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttggttcacctttacaactCccatgccctgggatccactg	7	13	7	14	0	1	0	1	0	0	0	3	1	3	1	4	2	3	1	4	2	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr1:247751981C>T	uc010pyy.1	+	1	320	c.320C>T	c.(319-321)TCC>TTC	p.S107F		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTTTACAACTCCCATGCCCTG	0.537													58	161					0	0	0	0	T	247751981	T	T	247751981	3	4	122	1	0	0	0	0	1	0	0	0	11052	855	30	2	322	2	OR2G2	1	247751981	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	417	247751981	1498640	77	21524											
GEN1	348654	broad.mit.edu	37	chr2	17946179	17946179	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttcagtgcctccatatgctcGaatgcttaggaatcccctgg	8	12	9	12	1	1	0	1	0	0	0	4	2	3	1	4	2	3	2	4	2	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:17946179G>C	uc002rct.2	+	4	437	c.364G>C	c.(364-366)GAA>CAA	p.E122Q	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.E122Q|GEN1_uc002rcu.2_Missense_Mutation_p.E122Q	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	122	I-domain.				DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CCATATGCTCGAATGCTTAGG	0.428								Homologous_recombination					68	27					0	0	0	0	C	17946179	C	C	17946179	3	2	122	1	0	0	0	0	1	0	0	0	6372	1059	37	3	374	3	GEN1	2	17946179	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08		17946179	225253194	78	21525											
ITSN2	50618	broad.mit.edu	37	chr2	24522802	24522802	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgtctttctatgtcttttctCctttcttcctctcgttgtct	1	23	4	13	2	7	0	0	0	7	0	10	0	8	0	2	0	0	1	2	0	1	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:24522802C>G	uc002rfe.2	-	12	1578	c.1320G>C	c.(1318-1320)AGG>AGC	p.R440S	ITSN2_uc002rff.2_Missense_Mutation_p.R440S|ITSN2_uc002rfg.2_Missense_Mutation_p.R440S|ITSN2_uc010eyd.2_Missense_Mutation_p.R465S	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	440	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTCTTTTCTCCTTTCTTCCT	0.299													50	18					0	0	0	0	G	24522802	G	G	24522802	3	3	122	1	0	0	0	0	1	0	0	0	7966	854	30	2	3940	2	ITSN2	2	24522802	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6576623	24522802	218676571	79	21526											
ITSN2	50618	broad.mit.edu	37	chr2	24522843	24522843	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccaattcccgttgcttctCtaagcgtttttctaattcaa	8	17	4	12	2	3	0	1	0	2	0	6	0	5	0	2	0	2	3	2	0	4	8			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:24522843C>G	uc002rfe.2	-	12	1537	c.1279G>C	c.(1279-1281)GAG>CAG	p.E427Q	ITSN2_uc002rff.2_Missense_Mutation_p.E427Q|ITSN2_uc002rfg.2_Missense_Mutation_p.E427Q|ITSN2_uc010eyd.2_Missense_Mutation_p.E452Q	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	427	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTTGCTTCTCTAAGCGTTTT	0.358													70	25					0	0	0	0	G	24522843	G	G	24522843	3	3	122	1	0	0	0	0	1	0	0	0	7966	922	32	2	3981	2	ITSN2	2	24522843	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	41	24522843	218676530	80	21527											
IFT172	26160	broad.mit.edu	37	chr2	27712512	27712512	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagggtcctcaggtgcttCaagtgcatgacgcacacctg	9	8	12	12	1	2	1	2	1	0	0	3	1	3	1	2	2	3	4	2	2	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:27712512C>T	uc002rku.2	-	1	60	c.9G>A	c.(7-9)TTG>TTA	p.L3L	IFT172_uc002rkw.2_Silent_p.L3L|IFT172_uc010yls.1_5'UTR|IFT172_uc010ezc.2_Silent_p.L3L|IFT172_uc002rkv.2_Silent_p.L3L|IFT172_uc010ylt.1_Silent_p.L3L	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	3					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TCAGGTGCTTCAAGTGCATGA	0.562													26	12					0	0	0	0	T	27712512	T	T	27712512	2	4	122	1	0	0	0	0	0	0	0	1	7596	825	29	2		2	IFT172	2	27712512	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	3189669	27712512	215486861	81	21528											
LTBP1	4052	broad.mit.edu	37	chr2	33488459	33488459	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgctcctactcaagtgacaGgttggtgcagtatttttaca	9	15	9	8	0	1	1	1	1	0	0	2	1	2	1	1	2	4	4	1	2	4	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:33488459G>T	uc002ros.2	+	15	2620	c.2620G>T	c.(2620-2622)GAA>TAA	p.E874*	LTBP1_uc002rot.2_Nonsense_Mutation_p.E548*|LTBP1_uc002rou.2_Nonsense_Mutation_p.E547*|LTBP1_uc002rov.2_Nonsense_Mutation_p.E494*|LTBP1_uc010ymz.1_Nonsense_Mutation_p.E547*|LTBP1_uc010yna.1_Nonsense_Mutation_p.E494*	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	873	EGF-like 4; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCAAGTGACAGGTTGGTGCAG	0.378													32	71					1.62565e-12	1.71854e-12	1	0	T	33488459	T	T	33488459	4	4	122	1	0	0	0	0	0	1	0	0	9123	1014	35	4	2730	4	LTBP1	2	33488459	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5775947	33488459	209710914	82	21529											
SOS1	6654	broad.mit.edu	37	chr2	39262376	39262376	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaagttcaaagtaatggaGacagtggtaaacaggggcca	17	6	12	6	0	1	1	1	0	0	1	1	2	1	1	1	4	1	3	1	4	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:39262376G>C	uc002rrk.3	-	8	1092	c.1051C>G	c.(1051-1053)CTC>GTC	p.L351V	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_5'UTR|SOS1_uc002rrl.2_Missense_Mutation_p.L83V	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	351	DH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				AAGTAATGGAGACAGTGGTAA	0.313									Noonan_syndrome				3	13					0	0	0	0	C	39262376	C	C	39262376	3	2	122	1	0	0	0	0	1	0	0	0	15000	942	33	2	3014	2	SOS1	2	39262376	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5773917	39262376	203936997	83	21530											
EPCAM	4072	broad.mit.edu	37	chr2	47596657	47596657	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgcagcatggcgcccccgCaggtcctcgcgttcgggctt	3	7	14	17	7	0	0	0	0	0	0	3	0	1	0	3	3	1	5	3	3	0	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:47596657C>T	uc002rvx.2	+	1	371	c.13C>T	c.(13-15)CAG>TAG	p.Q5*	EPCAM_uc002rvw.2_Intron	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	5					positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						GGCGCCCCCGCAGGTCCTCGC	0.463									Lynch_syndrome				8	5					0	0	0	0	T	47596657	T	T	47596657	4	4	122	1	0	0	0	0	0	1	0	0	5186	711	25	4	15	4	EPCAM	2	47596657	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	8334281	47596657	195602716	84	21531											
KLRAQ1	129285	broad.mit.edu	37	chr2	48707126	48707126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttaacaaatgttggtgctgCtctgcatggatttcatgacg	9	14	11	7	1	2	1	1	1	1	0	2	2	2	2	0	2	4	5	0	2	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:48707126C>T	uc002rwm.2	+	13	1474	c.1289C>T	c.(1288-1290)GCT>GTT	p.A430V	KLRAQ1_uc002rwj.2_Missense_Mutation_p.A430V|KLRAQ1_uc002rwl.2_Missense_Mutation_p.A384V|KLRAQ1_uc002rwk.2_Missense_Mutation_p.A430V|KLRAQ1_uc010yok.1_Missense_Mutation_p.A430V	NM_001135629	NP_001129101	Q6ZMI0	KLRAQ_HUMAN	KLRAQ motif containing 1 isoform 1	430										ovary(1)	1						GTTGGTGCTGCTCTGCATGGA	0.403													59	28					0	0	0	0	T	48707126	T	T	48707126	3	4	122	1	0	0	0	0	1	0	0	0	8452	797	28	4	1339	4	KLRAQ1	2	48707126	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1110469	48707126	194492247	85	21532											
RTN4	57142	broad.mit.edu	37	chr2	55253905	55253905	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtactggggaaagaagtatCatcattactactctcactat	13	12	7	9	1	3	1	3	0	1	1	4	2	3	2	0	2	3	2	0	2	7	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:55253905C>G	uc002rye.2	-	3	1628	c.1330G>C	c.(1330-1332)GAT>CAT	p.D444H	RTN4_uc002ryd.2_Missense_Mutation_p.D238H|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	444	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						AAAGAAGTATCATCATTACTA	0.398													5	240					0	0	0	0	G	55253905	G	G	55253905	3	3	122	1	0	0	0	0	1	0	0	0	13793	826	29	2	2314	2	RTN4	2	55253905	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6546779	55253905	187945468	86	21533											
AAK1	22848	broad.mit.edu	37	chr2	69732794	69732794	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctgagcctccaagcttctCgggatgtttgcctggagaga	8	10	13	10	1	1	2	0	1	1	1	3	5	2	4	3	2	4	3	3	2	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:69732794C>T	uc002sfp.2	-	16	2681	c.2176G>A	c.(2176-2178)GAG>AAG	p.E726K	AAK1_uc010fdk.2_Missense_Mutation_p.E726K|AAK1_uc010yqm.1_Missense_Mutation_p.E727K	NM_014911	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	726						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity				0						CCAAGCTTCTCGGGATGTTTG	0.488													13	5					0	0	0	0	T	69732794	T	T	69732794	3	4	122	1	0	0	0	0	1	0	0	0	16	893	31	1	737	1	AAK1	2	69732794	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	14478889	69732794	173466579	87	21534											
EXOC6B	23233	broad.mit.edu	37	chr2	72562091	72562091	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttacttgtctcaagtcgatGaaggccaactgcagcgtgtc	9	11	10	11	2	1	1	1	1	1	0	4	2	1	1	1	1	4	1	1	1	4	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:72562091G>A	uc010fep.2	-	20	2319	c.2181C>T	c.(2179-2181)TTC>TTT	p.F727F		NM_015189	NP_056004	Q9Y2D4	EXC6B_HUMAN	SEC15-like 2	727					protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2						TCAAGTCGATGAAGGCCAACT	0.458													48	33					0	0	0	0	A	72562091	A	A	72562091	2	1	122	1	0	0	0	0	0	0	0	1	5333	1281	45	2		2	EXOC6B	2	72562091	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2829297	72562091	170637282	88	21535											
NAT8B	51471	broad.mit.edu	37	chr2	73928298	73928298	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaagggcccccccaagtaaGagtatgagggttcgaggcag	11	5	15	10	1	0	2	0	1	0	1	1	3	0	2	3	3	0	5	3	3	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:73928298G>C	uc002sjk.1	-	2	170	c.135C>G	c.(133-135)CTC>CTG	p.L45L		NM_016347	NP_057431	Q9UHF3	NAT8B_HUMAN	N-acetyltransferase 8B	45	Helical; (Potential).				gastrulation with mouth forming second	integral to membrane	N-acetyltransferase activity				0						CCCCAAGTAAGAGTATGAGGG	0.632													39	15					0	0	0	0	C	73928298	C	C	73928298	2	2	122	1	0	0	0	0	0	0	0	1	10233	929	33	2		2	NAT8B	2	73928298	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1366207	73928298	169271075	89	21536											
POLR1A	25885	broad.mit.edu	37	chr2	86276328	86276328	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaatgatacgttgcctcttGacatctgcctttggcttcac	7	15	7	12	1	4	2	2	2	2	0	4	2	4	2	2	1	3	2	2	1	2	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:86276328G>C	uc002sqs.2	-	17	2809	c.2430C>G	c.(2428-2430)GTC>GTG	p.V810V	POLR1A_uc010ytb.1_Silent_p.V176V	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	810					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GTTGCCTCTTGACATCTGCCT	0.542													46	30					0	0	0	0	C	86276328	C	C	86276328	2	2	122	1	0	0	0	0	0	0	0	1	12264	1277	45	2		2	POLR1A	2	86276328	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	12348030	86276328	156923045	90	21537											
KIAA1310	55683	broad.mit.edu	37	chr2	97278577	97278577	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcccaagcaggacagctgaGattgccagaagcggtggcgg	10	5	16	10	2	0	2	0	1	0	2	0	4	0	3	2	4	5	2	2	4	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:97278577G>C	uc002swn.3	-	7	1036	c.890C>G	c.(889-891)TCT>TGT	p.S297C	KIAA1310_uc002swh.3_Missense_Mutation_p.S185C|KIAA1310_uc002swi.3_Missense_Mutation_p.S198C|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Missense_Mutation_p.S210C|KIAA1310_uc010fhz.2_Missense_Mutation_p.S91C|KIAA1310_uc002swl.3_Missense_Mutation_p.S198C|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Missense_Mutation_p.S91C|KIAA1310_uc002swp.1_Missense_Mutation_p.S198C|KIAA1310_uc002swq.1_Missense_Mutation_p.S69C|KIAA1310_uc010fhy.1_Missense_Mutation_p.S198C	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	297											0						GGACAGCTGAGATTGCCAGAA	0.552													3	1					0	0	0	0	C	97278577	C	C	97278577	3	2	122	1	0	0	0	0	1	0	0	0	8261	942	33	2	1806	2	KIAA1310	2	97278577	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	11002249	97278577	145920796	91	21538											
LMAN2L	81562	broad.mit.edu	37	chr2	97400156	97400156	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctcccaatacctggctgcatCcgatcctttgtgtaccagat	8	12	7	14	1	0	1	0	0	0	1	3	2	3	1	5	1	3	3	5	1	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:97400156C>G	uc002swu.2	-	3	450	c.414G>C	c.(412-414)CGG>CGC	p.R138R	LMAN2L_uc002swv.2_Silent_p.R138R|LMAN2L_uc010yut.1_Missense_Mutation_p.G21A|LMAN2L_uc010yuu.1_5'UTR|LMAN2L_uc010yuv.1_5'UTR|LMAN2L_uc010yuw.1_Missense_Mutation_p.G21A|LMAN2L_uc002sww.2_5'UTR|LMAN2L_uc010yux.1_Missense_Mutation_p.G21A	NM_030805	NP_110432	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like isoform 2	138	L-type lectin-like.|Lumenal (Potential).				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding				0						CTGGCTGCATCCGATCCTTTG	0.498													53	49					0	0	0	0	G	97400156	G	G	97400156	2	3	122	1	0	0	0	0	0	0	0	1	8881	842	30	2		2	LMAN2L	2	97400156	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	121579	97400156	145799217	92	21539											
NEB	4703	broad.mit.edu	37	chr2	152507244	152507244	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacatgtccactgggctggaGaacttagttttccacttctc	9	13	8	11	0	1	1	0	0	1	1	4	2	3	1	2	2	2	2	2	2	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:152507244G>A	uc010fnx.2	-	53	7262	c.7071C>T	c.(7069-7071)TTC>TTT	p.F2357F		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2357	Nebulin 63.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTGGGCTGGAGAACTTAGTTT	0.458													135	108					0	0	0	0	A	152507244	A	A	152507244	2	1	122	1	0	0	0	0	0	0	0	1	10356	933	33	2		2	NEB	2	152507244	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	55107088	152507244	90692129	93	21540											
PRPF40A	55660	broad.mit.edu	37	chr2	153573906	153573906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagctcccgtccccggcctCatcgtcgggctcagactgct	4	9	10	18	4	3	1	3	0	0	1	7	1	5	1	4	2	2	3	4	2	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:153573906C>T	uc002tyi.2	-	1	16	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ARL6IP6_uc002tyn.2_5'Flank|ARL6IP6_uc002tym.2_5'Flank|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_Missense_Mutation_p.M16I|PRPF40A_uc010zcd.1_Missense_Mutation_p.M16I|PRPF40A_uc002tyj.2_5'UTR|PRPF40A_uc002tyl.1_Missense_Mutation_p.M1I	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	1					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						TCCCCGGCCTCATCGTCGGGC	0.642													14	11					0	0	0	0	T	153573906	T	T	153573906	3	4	122	1	0	0	0	0	1	0	0	0	12633	826	29	2	2848	2	PRPF40A	2	153573906	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1066662	153573906	89625467	94	21541											
KCNH7	90134	broad.mit.edu	37	chr2	163250937	163250937	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaatgacaatttccttcttCttagtttacagttgtctcct	9	18	4	10	0	3	1	0	1	3	0	5	1	4	1	2	0	1	2	2	0	4	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:163250937C>T	uc002uch.1	-	12	2884	c.2672G>A	c.(2671-2673)AGA>AAA	p.R891K		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	891	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TTTCCTTCTTCTTAGTTTACA	0.333													30	19					0	0	0	0	T	163250937	T	T	163250937	3	4	122	1	0	0	0	0	1	0	0	0	8076	913	32	2	938	2	KCNH7	2	163250937	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	9677031	163250937	79948436	95	21542											
PLEKHA3	65977	broad.mit.edu	37	chr2	179365828	179365828	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccagtatctacacttcacCgactctcccagcgacgccga	11	7	6	17	4	3	0	1	0	2	0	4	3	3	0	4	0	3	1	4	0	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:179365828C>T	uc002umn.2	+	7	1098	c.700C>T	c.(700-702)CGA>TGA	p.R234*		NM_019091	NP_061964	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A	234						cytoplasm|membrane				ovary(1)|kidney(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			TACACTTCACCGACTCTCCCA	0.388													57	29					0	0	0	0	T	179365828	T	T	179365828	4	4	122	1	0	0	0	0	0	1	0	0	12112	644	23	1	726	1	PLEKHA3	2	179365828	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	16114891	179365828	63833545	96	21543											
TTN	7273	broad.mit.edu	37	chr2	179416824	179416824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatcttccagttagtttgtGaagtttcccgcttctcgatg	6	16	8	11	2	2	1	0	1	2	0	5	2	4	1	3	0	0	4	3	0	2	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:179416824G>A	uc010zfg.1	-	284	83323	c.83099C>T	c.(83098-83100)TCA>TTA	p.S27700L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S21395L|TTN_uc010zfi.1_Missense_Mutation_p.S21328L|TTN_uc010zfj.1_Missense_Mutation_p.S21203L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28627							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTAGTTTGTGAAGTTTCCCG	0.423													67	40					0	0	0	0	A	179416824	A	A	179416824	3	1	122	1	0	0	0	0	1	0	0	0	16803	1294	45	2	17288	2	TTN	2	179416824	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	50996	179416824	63782549	97	21544											
COL5A2	1290	broad.mit.edu	37	chr2	189932835	189932835	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggaccagaggtacctggaGagccctattaaacagcaaga	15	5	12	9	0	0	3	0	0	0	3	0	6	0	4	3	3	4	2	3	3	5	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:189932835G>C	uc002uqk.2	-	21	1582	c.1307C>G	c.(1306-1308)TCT>TGT	p.S436C	COL5A2_uc010frx.2_Intron	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	436					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGTACCTGGAGAGCCCTATTA	0.537													34	29					0	0	0	0	C	189932835	C	C	189932835	3	2	122	1	0	0	0	0	1	0	0	0	3712	942	33	2	3328	2	COL5A2	2	189932835	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	10516011	189932835	53266538	98	21545											
C2orf62	375307	broad.mit.edu	37	chr2	219229377	219229377	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcttccagaccatccaGgtagaccatcagcaggctga	10	7	11	13	0	1	3	1	1	0	2	3	3	3	3	4	3	1	4	4	3	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:219229377G>A	uc002vhr.2	+	7	686	c.657G>A	c.(655-657)CAG>CAA	p.Q219Q	C2orf62_uc002vhs.2_Intron	NM_198559	NP_940961	Q7Z7H3	CB062_HUMAN	hypothetical protein LOC375307	219											0		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGACCATCCAGGTAGACCATC	0.582													24	11					0	0	0	0	A	219229377	A	A	219229377	2	1	122	1	0	0	0	0	0	0	0	1	2191	991	35	4		4	C2orf62	2	219229377	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	29296542	219229377	23969996	99	21546											
TRIP12	9320	broad.mit.edu	37	chr2	230643289	230643289	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggttttgaatatacttggTcccttcttggctccctgaaa	8	15	9	9	0	1	2	0	2	1	0	3	3	3	2	2	3	1	2	2	3	4	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:230643289T>C	uc002vpw.1	-	35	5108	c.4999A>G	c.(4999-5001)ACC>GCC	p.T1667A	TRIP12_uc002vpx.1_Missense_Mutation_p.T1715A|TRIP12_uc002vpy.1_Missense_Mutation_p.T1397A	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1667					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		ATATACTTGGTCCCTTCTTGG	0.403													30	39					0	0	0	0	C	230643289	C	C	230643289	3	2	122	1	0	0	0	0	1	0	0	0	16623	1667	58	5	1007	5	TRIP12	2	230643289	Missense_Mutation	SNP	T	TCGA-CR-6472-01A-11D-1870-08	11413912	230643289	12556084	100	21547											
ITM2C	81618	broad.mit.edu	37	chr2	231742261	231742261	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctccggcgccgggcaacgcgGaggcgtgagtggctggcttc	4	6	18	13	6	0	1	0	1	0	0	2	2	1	2	2	6	1	3	2	6	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:231742261G>A	uc002vqz.2	+	5	828	c.708G>A	c.(706-708)CGG>CGA	p.R236R	ITM2C_uc002vra.2_Silent_p.R189R|ITM2C_uc002vrb.2_Silent_p.R199R|ITM2C_uc002vrc.2_Silent_p.R125R|ITM2C_uc002vrd.2_Silent_p.R88R	NM_030926	NP_112188	Q9NQX7	ITM2C_HUMAN	integral membrane protein 2C isoform 1	236					negative regulation of neuron projection development|neuron differentiation	Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	beta-amyloid binding				0		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;8.47e-12)|all cancers(144;3.44e-09)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		GGGCAACGCGGAGGCGTGAGT	0.622													23	26					0	0	0	0	A	231742261	A	A	231742261	2	1	122	1	0	0	0	0	0	0	0	1	7953	1161	41	2		2	ITM2C	2	231742261	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1098972	231742261	11457112	101	21548											
EIF4E2	9470	broad.mit.edu	37	chr2	233421129	233421129	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgcctttccattcagtttGaaagatgatgacagtgggga	10	13	12	6	0	1	4	1	3	0	1	2	5	2	5	2	2	1	2	2	2	1	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr2:233421129G>C	uc002vta.2	+	2	102	c.24G>C	c.(22-24)TTG>TTC	p.L8F	EIF4E2_uc002vtb.1_Missense_Mutation_p.L8F|EIF4E2_uc002vsz.2_Missense_Mutation_p.L8F|EIF4E2_uc010zmi.1_Missense_Mutation_p.L8F	NM_004846	NP_004837	O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E	8				MNNKFDALKDDDSGDHDQNEENSTQKD -> MMTVGTMIRM KKTAHRKI (in Ref. 3; AAC39871).	regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CATTCAGTTTGAAAGATGATG	0.413													14	11					0	0	0	0	C	233421129	C	C	233421129	3	2	122	1	0	0	0	0	1	0	0	0	5054	1281	45	2	30	2	EIF4E2	2	233421129	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1678868	233421129	9778244	102	21549											
CRELD1	78987	broad.mit.edu	37	chr3	9984547	9984547	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtggagctgaccaattcTgcgtgaacactgagggctcc	9	9	12	11	1	1	3	0	3	1	0	2	4	2	4	2	2	3	2	2	2	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:9984547T>C	uc003bug.2	+	8	902	c.784T>C	c.(784-786)TGC>CGC	p.C262R	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Missense_Mutation_p.C262R|CRELD1_uc003buh.2_Missense_Mutation_p.C262R|CRELD1_uc003bui.2_Missense_Mutation_p.C262R|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	262	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						TGACCAATTCTGCGTGAACAC	0.448													32	47					0	0	0	0	C	9984547	C	C	9984547	3	2	122	1	0	0	0	0	1	0	0	0	3881	1580	55	5	810	5	CRELD1	3	9984547	Missense_Mutation	SNP	T	TCGA-CR-6472-01A-11D-1870-08		9984547	188037883	103	21550											
IRAK2	3656	broad.mit.edu	37	chr3	10264363	10264363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctcacccccaaacttgctCacccaatggctcatctgtgt	9	11	5	16	0	4	0	3	0	2	0	5	0	4	0	3	1	2	2	3	1	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:10264363C>T	uc003bve.1	+	9	1133	c.1057C>T	c.(1057-1059)CAC>TAC	p.H353Y		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	353	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						CAAACTTGCTCACCCAATGGC	0.473													68	111					0	0	0	0	T	10264363	T	T	10264363	3	4	122	1	0	0	0	0	1	0	0	0	7862	826	29	2	1091	2	IRAK2	3	10264363	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	279816	10264363	187758067	104	21551											
TSEN2	80746	broad.mit.edu	37	chr3	12545233	12545233	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accatgagtacgtgctggtcGaggaagcggagtgtgccatg	9	8	16	8	3	0	1	0	1	0	0	1	4	0	3	2	3	4	2	2	3	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:12545233G>A	uc003bxc.2	+	5	1168	c.781G>A	c.(781-783)GAG>AAG	p.E261K	TSEN2_uc003bwy.2_Missense_Mutation_p.E261K|TSEN2_uc003bwz.2_Missense_Mutation_p.E202K|TSEN2_uc003bxa.2_Missense_Mutation_p.E261K|TSEN2_uc011auq.1_Missense_Mutation_p.E261K|TSEN2_uc003bxb.2_Missense_Mutation_p.E261K|TSEN2_uc011aur.1_Missense_Mutation_p.E170K	NM_025265	NP_079541	Q8NCE0	SEN2_HUMAN	tRNA-intron nuclease 2 isoform 1	261					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(1)	1						CGTGCTGGTCGAGGAAGCGGA	0.567													14	28					0	0	0	0	A	12545233	A	A	12545233	3	1	122	1	0	0	0	0	1	0	0	0	16679	1059	37	1	795	1	TSEN2	3	12545233	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2280870	12545233	185477197	105	21552											
NR1D2	9975	broad.mit.edu	37	chr3	23996052	23996052	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgattgcctatatcagttCttccagctcagcctcaagcc	8	13	7	13	0	4	1	3	1	1	0	5	1	5	1	4	0	4	2	4	0	3	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:23996052C>G	uc003ccs.2	+	2	360	c.41C>G	c.(40-42)TCT>TGT	p.S14C	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_5'UTR	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	14	Poly-Ser.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						TATATCAGTTCTTCCAGCTCA	0.398													57	94					0	0	0	0	G	23996052	G	G	23996052	3	3	122	1	0	0	0	0	1	0	0	0	10670	913	32	2	47	2	NR1D2	3	23996052	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	11450819	23996052	174026378	106	21553											
NEK10	152110	broad.mit.edu	37	chr3	27244013	27244013	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctactgcccagacatcagccTtctccccatacggctcactc	8	9	5	19	1	3	1	2	0	1	1	5	1	3	1	4	1	4	1	4	1	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:27244013T>G	uc010hfk.2	-	3	291	c.62A>C	c.(61-63)AAG>ACG	p.K21T	NEK10_uc003cds.1_Missense_Mutation_p.K106T|NEK10_uc010hfj.2_Missense_Mutation_p.K21T			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	709	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						GACATCAGCCTTCTCCCCATA	0.478													27	35					0	0	0	0	G	27244013	G	G	27244013	3	3	122	1	0	0	0	0	1	0	0	0	10376	1624	56	5		5	NEK10	3	27244013	Missense_Mutation	SNP	T	TCGA-CR-6472-01A-11D-1870-08	3247961	27244013	170778417	107	21554											
ZNF860	344787	broad.mit.edu	37	chr3	32031248	32031248	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaacaggaagtacacataaGagaaaaatctttccaatgta	21	8	6	6	0	1	1	0	0	1	1	2	3	2	2	1	1	2	2	1	1	9	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:32031248G>C	uc011axg.1	+	2	1226	c.677G>C	c.(676-678)AGA>ACA	p.R226T		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTACACATAAGAGAAAAATCT	0.308													29	83					0	0	0	0	C	32031248	C	C	32031248	3	2	122	1	0	0	0	0	1	0	0	0	18261	942	33	2	679	2	ZNF860	3	32031248	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4787235	32031248	165991182	108	21555											
CNOT10	25904	broad.mit.edu	37	chr3	32776347	32776347	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagtttgcagccatatgtCtcagaaatgccttgttgctg	8	14	11	8	0	1	1	1	0	1	1	2	2	1	2	2	1	4	4	2	1	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:32776347C>A	uc003cfc.1	+	12	1648	c.1393C>A	c.(1393-1395)CTC>ATC	p.L465I	CNOT10_uc011axi.1_Missense_Mutation_p.L237I|CNOT10_uc003cfd.1_Missense_Mutation_p.L464I|CNOT10_uc003cfe.1_Missense_Mutation_p.L465I|CNOT10_uc010hfv.1_RNA|CNOT10_uc011axj.1_Missense_Mutation_p.L525I|CNOT10_uc010hfw.1_Missense_Mutation_p.L160I	NM_015442	NP_056257	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	465					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			central_nervous_system(1)|skin(1)	2						AGCCATATGTCTCAGAAATGC	0.408													93	167					1.66795e-42	1.85033e-42	1	0	A	32776347	A	A	32776347	3	1	122	1	0	0	0	0	1	0	0	0	3633	913	32	2	1439	2	CNOT10	3	32776347	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	745099	32776347	165246083	109	21556											
TRANK1	9881	broad.mit.edu	37	chr3	36884182	36884182	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaggagttgaggtcttaacGaacatgctatcatcaaagtc	13	10	10	8	1	3	1	2	1	1	0	4	3	3	2	0	2	3	3	0	2	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:36884182G>A	uc003cgj.2	-	8	3731	c.3429C>T	c.(3427-3429)TTC>TTT	p.F1143F		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1693					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						AGGTCTTAACGAACATGCTAT	0.408													10	28					0	0	0	0	A	36884182	A	A	36884182	2	1	122	1	0	0	0	0	0	0	0	1	16521	1049	37	1		1	TRANK1	3	36884182	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4107835	36884182	161138248	110	21557											
TMEM42	131616	broad.mit.edu	37	chr3	44903512	44903512	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccgcacctccaggcgggtgcGatgcggcgccgcttttgggg	3	7	17	14	6	0	0	0	0	0	0	1	1	1	0	4	5	2	2	4	5	0	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:44903512G>C	uc003cnz.2	+	1	105	c.96G>C	c.(94-96)GCG>GCC	p.A32A		NM_144638	NP_653239	Q69YG0	TMM42_HUMAN	transmembrane protein 42	32						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.00839)|KIRC - Kidney renal clear cell carcinoma(197;0.0461)|Kidney(197;0.0576)		AGGCGGGTGCGATGCGGCGCC	0.741													4	3					0	0	0	0	C	44903512	C	C	44903512	2	2	122	1	0	0	0	0	0	0	0	1	16232	1045	37	3		3	TMEM42	3	44903512	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8019330	44903512	153118918	111	21558											
PLXNB1	5364	broad.mit.edu	37	chr3	48451107	48451107	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctggtgctgagaatcacctgGaacaggtcatccacgaactt	11	9	10	11	1	2	1	2	1	0	1	3	4	3	2	2	3	3	1	2	3	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:48451107G>C	uc003csw.2	-	33	6081	c.5811C>G	c.(5809-5811)TTC>TTG	p.F1937L	PLXNB1_uc003cst.2_Missense_Mutation_p.F387L|PLXNB1_uc003csu.2_Missense_Mutation_p.F1754L|PLXNB1_uc003csx.2_Missense_Mutation_p.F1937L	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	1937	Cytoplasmic (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAATCACCTGGAACAGGTCAT	0.607													20	48					0	0	0	0	C	48451107	C	C	48451107	3	2	122	1	0	0	0	0	1	0	0	0	12178	1165	41	2	620	2	PLXNB1	3	48451107	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3547595	48451107	149571323	112	21559											
CELSR3	1951	broad.mit.edu	37	chr3	48699002	48699002	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtagactaggcgcccggcctCgccggcgtccgggtcctgag	4	6	16	15	6	0	2	0	1	0	1	3	2	2	2	5	4	0	1	5	4	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:48699002C>G	uc003cul.2	-	1	1347	c.1066G>C	c.(1066-1068)GAG>CAG	p.E356Q	CELSR3_uc003cuf.1_Missense_Mutation_p.E426Q	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	356	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGCCCGGCCTCGCCGGCGTCC	0.672													24	45					0	0	0	0	G	48699002	G	G	48699002	3	3	122	1	0	0	0	0	1	0	0	0	3238	893	31	3	9012	3	CELSR3	3	48699002	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	247895	48699002	149323428	113	21560											
USP19	10869	broad.mit.edu	37	chr3	49152909	49152909	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cccggagttcccgagtgttgGacagagactgaatgacgctg	9	8	14	10	3	0	3	0	2	0	1	1	7	1	5	2	2	0	3	2	2	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:49152909G>C	uc003cwd.1	-	11	1708	c.1547C>G	c.(1546-1548)TCC>TGC	p.S516C	USP19_uc003cwa.2_Missense_Mutation_p.S324C|USP19_uc003cvz.3_Missense_Mutation_p.S619C|USP19_uc011bcg.1_Missense_Mutation_p.S607C|USP19_uc003cwb.2_Missense_Mutation_p.S602C|USP19_uc003cwc.1_Missense_Mutation_p.S274C|USP19_uc011bch.1_Missense_Mutation_p.S617C|USP19_uc011bci.1_Missense_Mutation_p.S604C	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	516	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCGAGTGTTGGACAGAGACTG	0.483													49	56					0	0	0	0	C	49152909	C	C	49152909	3	2	122	1	0	0	0	0	1	0	0	0	17118	1174	41	2	2473	2	USP19	3	49152909	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	453907	49152909	148869521	114	21561											
USP19	10869	broad.mit.edu	37	chr3	49155409	49155409	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctgctcctcttgaggagtgGatgctgaccctgacgatgaa	8	11	12	10	1	2	4	0	4	2	0	3	7	3	6	2	2	2	2	2	2	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:49155409G>A	uc003cwd.1	-	3	430	c.269C>T	c.(268-270)TCC>TTC	p.S90F	USP19_uc003cwa.2_5'UTR|USP19_uc003cvz.3_Missense_Mutation_p.S90F|USP19_uc011bcg.1_Missense_Mutation_p.S90F|USP19_uc003cwb.2_Missense_Mutation_p.S90F|USP19_uc003cwc.1_5'Flank|USP19_uc011bch.1_Missense_Mutation_p.S90F|USP19_uc011bci.1_Missense_Mutation_p.S90F	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	90	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TTGAGGAGTGGATGCTGACCC	0.338													63	43					0	0	0	0	A	49155409	A	A	49155409	3	1	122	1	0	0	0	0	1	0	0	0	17118	1174	41	2	3783	2	USP19	3	49155409	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2500	49155409	148867021	115	21562											
CCDC36	339834	broad.mit.edu	37	chr3	49278740	49278740	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagatggaggtttatttcctCctcctttgtcagttggaaaa	10	15	9	7	0	1	1	1	0	0	1	4	3	4	3	3	3	0	2	3	3	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:49278740C>T	uc003cwk.2	+	6	700	c.313C>T	c.(313-315)CCT>TCT	p.P105S	CCDC36_uc003cwl.3_Missense_Mutation_p.P105S|CCDC36_uc011bck.1_Missense_Mutation_p.P105S|CCDC36_uc010hkt.2_RNA	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	105										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		TTTATTTCCTCCTCCTTTGTC	0.383													15	33					0	0	0	0	T	49278740	T	T	49278740	3	4	122	1	0	0	0	0	1	0	0	0	2821	855	30	2	323	2	CCDC36	3	49278740	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	123331	49278740	148743690	116	21563											
MST1R	4486	broad.mit.edu	37	chr3	49929191	49929191	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatcttctgccccacttacGacttagtgacttgatggcac	8	12	7	14	1	2	2	0	2	2	0	2	3	2	2	3	1	2	1	3	1	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:49929191G>A	uc003cxy.3	-	15	3616	c.3352C>T	c.(3352-3354)CGC>TGC	p.R1118C	MST1R_uc011bdc.1_5'UTR	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1118	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CCCCACTTACGACTTAGTGAC	0.527													49	86					0	0	0	0	A	49929191	A	A	49929191	3	1	122	1	0	0	0	0	1	0	0	0	9944	1072	37	1	874	1	MST1R	3	49929191	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	650451	49929191	148093239	117	21564											
PDZRN3	23024	broad.mit.edu	37	chr3	73651507	73651507	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggccagtattcacatacctCaataatcctgtcatgaattt	12	14	5	10	0	3	1	3	1	0	0	4	1	4	1	3	1	1	1	3	1	5	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:73651507C>G	uc003dpl.1	-	3	1012	c.916G>C	c.(916-918)GAG>CAG	p.E306Q		NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	306	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TCACATACCTCAATAATCCTG	0.478													79	133					0	0	0	0	G	73651507	G	G	73651507	3	3	122	1	0	0	0	0	1	0	0	0	11763	835	29	2	2316	2	PDZRN3	3	73651507	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	23722316	73651507	124370923	118	21565											
ROBO1	6091	broad.mit.edu	37	chr3	78737857	78737857	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttccggttgcttcacactGaaaagttacagtccgtccca	10	12	7	12	2	1	1	1	1	0	0	4	1	4	1	3	1	2	3	3	1	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:78737857G>T	uc003dqe.2	-	9	1319	c.1111C>A	c.(1111-1113)CAG>AAG	p.Q371K	ROBO1_uc003dqb.2_Missense_Mutation_p.Q332K|ROBO1_uc003dqc.2_Missense_Mutation_p.Q335K|ROBO1_uc003dqd.2_Missense_Mutation_p.Q335K|ROBO1_uc010hoh.2_5'UTR|ROBO1_uc003dqf.1_Missense_Mutation_p.Q50K	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	371	Extracellular (Potential).|Ig-like C2-type 4.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GCTTCACACTGAAAAGTTACA	0.413													7	8					0.00198382	0.00200292	1	0	T	78737857	T	T	78737857	3	4	122	1	0	0	0	0	1	0	0	0	13578	1299	45	2	3936	2	ROBO1	3	78737857	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5086350	78737857	119284573	119	21566											
PROS1	5627	broad.mit.edu	37	chr3	93646189	93646189	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attaccctgtttggtttcttCaagtaaagaatttgcacgac	11	15	7	8	1	2	1	1	0	1	1	2	2	2	1	1	1	2	4	1	1	5	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:93646189C>G	uc003drb.3	-	2	480	c.139G>C	c.(139-141)GAA>CAA	p.E47Q	PROS1_uc010hoo.2_5'UTR|PROS1_uc003dqz.3_5'UTR	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	47	Gla.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTGGTTTCTTCAAGTAAAGAA	0.388													38	53					0	0	0	0	G	93646189	G	G	93646189	3	3	122	1	0	0	0	0	1	0	0	0	12620	835	29	2	1947	2	PROS1	3	93646189	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	14908332	93646189	104376241	120	21567											
EPHA6	285220	broad.mit.edu	37	chr3	97439174	97439174	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaaaattctcctcagcaagcGatgcatggagctatggcatt	12	10	10	9	1	2	0	1	0	1	0	3	3	2	1	1	2	4	4	1	2	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:97439174G>C	uc010how.1	+	15	2897	c.2854G>C	c.(2854-2856)GAT>CAT	p.D952H	EPHA6_uc003drt.2_Missense_Mutation_p.D344H|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	857	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CTCAGCAAGCGATGCATGGAG	0.463													38	53					0	0	0	0	C	97439174	C	C	97439174	3	2	122	1	0	0	0	0	1	0	0	0	5195	1058	37	3	3029	3	EPHA6	3	97439174	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3792985	97439174	100583256	121	21568											
KIAA1407	57577	broad.mit.edu	37	chr3	113724488	113724488	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgcaggtttttcttcagctCgagaattgttttctgctgtt	5	19	9	8	1	3	1	1	0	2	1	4	2	3	1	0	1	3	6	0	1	1	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:113724488C>G	uc003eax.2	-	10	1882	c.1735G>C	c.(1735-1737)GAG>CAG	p.E579Q	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.E557Q|KIAA1407_uc011bip.1_Missense_Mutation_p.E566Q	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	579	Potential.									ovary(2)	2						TTCTTCAGCTCGAGAATTGTT	0.507													48	96					0	0	0	0	G	113724488	G	G	113724488	3	3	122	1	0	0	0	0	1	0	0	0	8268	893	31	3	1107	3	KIAA1407	3	113724488	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	16285314	113724488	84297942	122	21569											
C3orf30	152405	broad.mit.edu	37	chr3	118865466	118865466	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacggaggaaagaactgctGaacagactgaacgaagatta	17	6	12	6	2	0	6	0	3	0	3	0	9	0	8	0	2	4	1	0	2	6	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:118865466G>T	uc003ecb.1	+	1	470	c.430G>T	c.(430-432)GAA>TAA	p.E144*	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Nonsense_Mutation_p.E144*	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	144										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		AAGAACTGCTGAACAGACTGA	0.488													19	37					1.45105e-14	1.53914e-14	1	0	T	118865466	T	T	118865466	4	4	122	1	0	0	0	0	0	1	0	0	2230	1291	45	2	432	2	C3orf30	3	118865466	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5140978	118865466	79156964	123	21570											
POLQ	10721	broad.mit.edu	37	chr3	121258384	121258384	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagagaaatgccttgatggaGaggtgctgcccatataaccg	13	8	12	8	1	0	3	0	1	0	2	0	5	0	3	3	2	4	1	3	2	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:121258384G>C	uc003eee.3	-	4	656	c.527C>G	c.(526-528)TCT>TGT	p.S176C		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	176	Helicase ATP-binding.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CCTTGATGGAGAGGTGCTGCC	0.393								DNA_polymerases_(catalytic_subunits)					22	48					0	0	0	0	C	121258384	C	C	121258384	3	2	122	1	0	0	0	0	1	0	0	0	12263	942	33	2	7353	2	POLQ	3	121258384	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2392918	121258384	76764046	124	21571											
CHCHD6	84303	broad.mit.edu	37	chr3	126451938	126451938	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caggtatgaacaggagcatgCtgctatccaggataagctct	12	9	11	9	0	1	1	0	1	1	0	2	3	2	3	1	3	5	5	1	3	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:126451938C>G	uc003ejf.1	+	4	322	c.284C>G	c.(283-285)GCT>GGT	p.A95G	CHCHD6_uc010hsj.1_Missense_Mutation_p.A95G	NM_032343	NP_115719	Q9BRQ6	CHCH6_HUMAN	coiled-coil-helix-coiled-coil-helix domain	95											0						CAGGAGCATGCTGCTATCCAG	0.552													8	57					0	0	0	0	G	126451938	G	G	126451938	3	3	122	1	0	0	0	0	1	0	0	0	3335	797	28	4	298	4	CHCHD6	3	126451938	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	5193554	126451938	71570492	125	21572											
COPG	22820	broad.mit.edu	37	chr3	128979529	128979529	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagaacctggtcacagattCaaaccgcagcattgccacgc	12	6	10	13	2	2	2	2	0	0	2	2	3	2	2	3	2	4	2	3	2	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:128979529C>G	uc003els.2	+	12	1107	c.1007C>G	c.(1006-1008)TCA>TGA	p.S336*	COPG_uc010htb.2_Nonsense_Mutation_p.S242*	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	336	HEAT 3.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						GTCACAGATTCAAACCGCAGC	0.552													33	43					0	0	0	0	G	128979529	G	G	128979529	4	3	122	1	0	0	0	0	0	1	0	0	3746	838	29	2	1053	2	COPG	3	128979529	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2527591	128979529	69042901	126	21573											
COL6A6	131873	broad.mit.edu	37	chr3	130293197	130293197	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccaggccgcggaagccctGagacacagaggtatcgacat	11	4	13	13	3	0	2	0	1	0	2	1	5	0	3	3	3	1	1	3	3	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:130293197G>A	uc010htl.2	+	7	3406	c.3375G>A	c.(3373-3375)CTG>CTA	p.L1125L		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1125	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CGGAAGCCCTGAGACACAGAG	0.567													27	52					0	0	0	0	A	130293197	A	A	130293197	2	1	122	1	0	0	0	0	0	0	0	1	3718	1277	45	2		2	COL6A6	3	130293197	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1313668	130293197	67729233	127	21574											
ACAD11	84129	broad.mit.edu	37	chr3	132294631	132294631	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcacatgtgcatacaacttCttcttgaaagctatcctttg	10	15	5	11	0	3	1	1	1	2	0	4	1	4	1	1	0	4	2	1	0	4	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:132294631C>G	uc003eov.3	-	17	2366	c.1986G>C	c.(1984-1986)AAG>AAC	p.K662N		NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	662						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						CATACAACTTCTTCTTGAAAG	0.438													23	54					0	0	0	0	G	132294631	G	G	132294631	3	3	122	1	0	0	0	0	1	0	0	0	109	912	32	2	372	2	ACAD11	3	132294631	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2001434	132294631	65727799	128	21575											
UBA5	79876	broad.mit.edu	37	chr3	132394720	132394720	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaaatttttcaggtccagttCcagacttacctgaaggaatt	13	13	7	8	0	1	2	1	1	0	1	3	3	3	3	3	2	1	1	3	2	5	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:132394720C>G	uc003epa.3	+	11	1326	c.1084C>G	c.(1084-1086)CCA>GCA	p.P362A	NPHP3_uc003eoz.1_Intron|UBA5_uc010htr.2_Missense_Mutation_p.P306A|UBA5_uc010htt.2_Intron|UBA5_uc003epb.3_Missense_Mutation_p.P306A|UBA5_uc003epc.2_5'Flank	NM_024818	NP_079094	Q9GZZ9	UBA5_HUMAN	ubiquitin-activating enzyme 5 isoform 1	362					protein ufmylation	aggresome|cytoplasm|cytoplasm|nucleus	ATP binding|cofactor binding|metal ion binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding|UFM1 activating enzyme activity			kidney(1)	1						AGGTCCAGTTCCAGACTTACC	0.308													24	33					0	0	0	0	G	132394720	G	G	132394720	3	3	122	1	0	0	0	0	1	0	0	0	16898	855	30	2	1126	2	UBA5	3	132394720	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	100089	132394720	65627710	129	21576											
NPHP3	27031	broad.mit.edu	37	chr3	132423059	132423059	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactttctcaaatcccaactCatgggctgaattagaagcct	12	12	6	11	0	2	2	2	1	1	1	4	2	3	2	2	1	3	1	2	1	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:132423059C>G	uc003epe.1	-	9	1584	c.1507G>C	c.(1507-1509)GAG>CAG	p.E503Q	NPHP3_uc003epf.1_Missense_Mutation_p.E258Q	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	503	TPR 1.				maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						AATCCCAACTCATGGGCTGAA	0.363													95	106					0	0	0	0	G	132423059	G	G	132423059	3	3	122	1	0	0	0	0	1	0	0	0	10634	835	29	2	2561	2	NPHP3	3	132423059	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	28339	132423059	65599371	130	21577											
KY	339855	broad.mit.edu	37	chr3	134327552	134327552	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttgttgtagaattcactCttgtgatacatgttgttctc	7	19	7	8	0	3	2	1	1	2	1	4	2	3	2	1	0	1	4	1	0	3	8			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:134327552C>G	uc010hty.2	-	10	1091	c.1029G>C	c.(1027-1029)AAG>AAC	p.K343N	KY_uc011blw.1_Intron|KY_uc011blx.1_Missense_Mutation_p.K322N|KY_uc003eqr.1_Missense_Mutation_p.K109N	NM_178554	NP_848649	Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	343						cytoskeleton|Z disc	peptidase activity			ovary(2)	2						AGAATTCACTCTTGTGATACA	0.507													56	75					0	0	0	0	G	134327552	G	G	134327552	3	3	122	1	0	0	0	0	1	0	0	0	8626	912	32	2	964	2	KY	3	134327552	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1904493	134327552	63694878	131	21578											
PLS1	5357	broad.mit.edu	37	chr3	142394998	142394998	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaaggttttctcctttcaGaggaagaaaaagtggctttt	12	13	9	7	0	2	2	1	0	1	2	3	3	2	3	2	3	0	2	2	3	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:142394998G>C	uc010huv.2	+	5	524	c.365_splice	c.e5-1	p.E122_splice	PLS1_uc003euz.2_Splice_Site_p.E122_splice|PLS1_uc003eva.2_Splice_Site_p.E122_splice	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1							cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						TCTCCTTTCAGAGGAAGAAAA	0.353													20	50					0	0	0	0	C	142394998	C	C	142394998	5	2	122	1	0	0	0	0	0	0	1	0	12162	956	33	2	378	2	PLS1	3	142394998	Splice_Site	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8067446	142394998	55627432	132	21579											
P2RY13	53829	broad.mit.edu	37	chr3	151046746	151046746	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtctctggggcaccgctcaGatctgttgaagccttgcatc	6	12	11	12	1	3	2	1	1	2	1	5	2	3	2	2	2	2	4	2	2	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:151046746G>C	uc003eyv.2	-	2	119	c.98C>G	c.(97-99)TCT>TGT	p.S33C	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	33	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			GCACCGCTCAGATCTGTTGAA	0.458													62	80					0	0	0	0	C	151046746	C	C	151046746	3	2	122	1	0	0	0	0	1	0	0	0	11404	942	33	2	970	2	P2RY13	3	151046746	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8651748	151046746	46975684	133	21580											
BCHE	590	broad.mit.edu	37	chr3	165548094	165548094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatggctctggtgaacaatGaatggcttccaggagaaagc	13	8	13	7	0	1	3	0	2	1	1	2	5	2	3	1	4	2	2	1	4	5	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:165548094G>A	uc003fem.3	-	2	888	c.728C>T	c.(727-729)TCA>TTA	p.S243L	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	243					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	GGTGAACAATGAATGGCTTCC	0.438													35	131					0	0	0	0	A	165548094	A	A	165548094	3	1	122	1	0	0	0	0	1	0	0	0	1360	1294	45	2	1092	2	BCHE	3	165548094	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	14501348	165548094	32474336	134	21581											
LRRIQ4	344657	broad.mit.edu	37	chr3	169540507	169540507	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acggaaatcgggctgagcggGaaccgcctggagaaggtgcc	10	4	17	10	4	0	2	0	1	0	1	1	5	0	4	3	5	3	1	3	5	3	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:169540507G>C	uc003fgb.2	+	1	798	c.798G>C	c.(796-798)GGG>GGC	p.G266G		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	266	LRR 11.										0						GGCTGAGCGGGAACCGCCTGG	0.612													26	19					0	0	0	0	C	169540507	C	C	169540507	2	2	122	1	0	0	0	0	0	0	0	1	9081	1161	41	2		2	LRRIQ4	3	169540507	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3992413	169540507	28481923	135	21582											
FNDC3B	64778	broad.mit.edu	37	chr3	172096154	172096154	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcagaatccaggcagcaagcGaggctggagaagggcccttc	11	5	14	11	1	1	2	1	0	0	2	3	4	2	2	2	4	2	3	2	4	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:172096154G>A	uc003fhy.2	+	24	3275	c.3103G>A	c.(3103-3105)GAG>AAG	p.E1035K	FNDC3B_uc003fhz.3_Missense_Mutation_p.E1035K	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	1035	Fibronectin type-III 8.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GGCAGCAAGCGAGGCTGGAGA	0.488													50	42					0	0	0	0	A	172096154	A	A	172096154	3	1	122	1	0	0	0	0	1	0	0	0	6002	1059	37	1	3193	1	FNDC3B	3	172096154	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2555647	172096154	25926276	136	21583											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			46	44					0	0	0	0	A	178936091	A	A	178936091	3	1	122	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	6839937	178936091	19086339	137	21584											
BCL6	604	broad.mit.edu	37	chr3	187447411	187447411	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttctgggattgtttccttgGgtgaatagatattgctgtgg	6	17	13	5	0	1	2	0	1	1	1	2	3	2	3	1	3	1	2	1	3	3	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:187447411G>C	uc003frp.3	-	5	1239	c.782C>G	c.(781-783)CCC>CGC	p.P261R	BCL6_uc011bsf.1_Missense_Mutation_p.P261R|BCL6_uc010hza.2_Missense_Mutation_p.P159R|BCL6_uc003frq.1_Missense_Mutation_p.P261R	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	261					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		TGTTTCCTTGGGTGAATAGAT	0.572			T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								28	62					0	0	0	0	C	187447411	C	C	187447411	3	2	122	1	0	0	0	0	1	0	0	0	1378	1232	43	4	1362	4	BCL6	3	187447411	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8511320	187447411	10575019	138	21585											
PPP1R2	5504	broad.mit.edu	37	chr3	195256617	195256617	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtaaggagtgcttggttCatctattttcattaaaccat	11	16	8	6	0	3	0	2	0	1	0	3	1	3	1	1	3	2	3	1	3	4	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr3:195256617C>A	uc003fup.2	-	2	584	c.208G>T	c.(208-210)GAA>TAA	p.E70*	PPP1R2_uc003fuq.3_Nonsense_Mutation_p.E70*	NM_006241	NP_006232	P41236	IPP2_HUMAN	protein phosphatase 1, regulatory subunit 2	70					glycogen metabolic process|regulation of phosphoprotein phosphatase activity|regulation of signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			urinary_tract(1)	1	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)		Epithelial(36;2.64e-22)|all cancers(36;2.69e-20)|OV - Ovarian serous cystadenocarcinoma(49;3.52e-19)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;9.55e-05)		GTGCTTGGTTCATCTATTTTC	0.373													60	52					2.73361e-28	3.01128e-28	1	0	A	195256617	A	A	195256617	4	1	122	1	0	0	0	0	0	1	0	0	12430	835	29	2	429	2	PPP1R2	3	195256617	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	7809206	195256617	2765813	139	21586											
FAM193A	8603	broad.mit.edu	37	chr4	2696731	2696731	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacgacccacagcaggatGatggggacgagagtgcagat	12	6	14	9	2	1	3	0	1	1	2	1	7	1	5	1	3	3	2	1	3	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:2696731G>T	uc010icl.2	+	15	2629	c.2278G>T	c.(2278-2280)GAT>TAT	p.D760Y	FAM193A_uc010ick.2_Missense_Mutation_p.D960Y|FAM193A_uc003gfd.2_Missense_Mutation_p.D760Y|FAM193A_uc011bvm.1_Missense_Mutation_p.D782Y|FAM193A_uc011bvn.1_Missense_Mutation_p.D760Y|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.D614Y	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	760										ovary(3)	3						ACAGCAGGATGATGGGGACGA	0.597													4	5					2.56e-06	2.63974e-06	1	0	T	2696731	T	T	2696731	3	4	122	1	0	0	0	0	1	0	0	0	5552	1290	45	2	2328	2	FAM193A	4	2696731	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08		2696731	188457545	140	21587											
LPHN3	23284	broad.mit.edu	37	chr4	62935975	62935975	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctataaccataacgagacCgccctagagaaaaagattct	16	7	8	10	2	1	3	0	0	1	3	1	5	1	3	3	1	2	1	3	1	6	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:62935975C>T	uc010ihh.2	+	23	3932	c.3759C>T	c.(3757-3759)ACC>ACT	p.T1253T	LPHN3_uc003hcq.3_3'UTR|LPHN3_uc003hct.2_Silent_p.T637T	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1231	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ATAACGAGACCGCCCTAGAGA	0.458													5	5					0	0	0	0	T	62935975	T	T	62935975	2	4	122	1	0	0	0	0	0	0	0	1	8967	639	23	1		1	LPHN3	4	62935975	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	60239244	62935975	128218301	141	21588											
EPHA5	2044	broad.mit.edu	37	chr4	66467879	66467879	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtcccgcagggtaaatttGagttctatgaagattctgga	11	12	11	7	1	2	3	0	2	2	1	3	4	3	4	1	2	0	3	1	2	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:66467879G>C	uc003hcy.2	-	3	583	c.390C>G	c.(388-390)CTC>CTG	p.L130L	EPHA5_uc003hcx.2_Silent_p.L61L|EPHA5_uc003hcz.2_Silent_p.L130L|EPHA5_uc011cah.1_Silent_p.L130L|EPHA5_uc011cai.1_Silent_p.L130L|EPHA5_uc003hda.2_Silent_p.L130L	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	130	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GGGTAAATTTGAGTTCTATGA	0.428										TSP Lung(17;0.13)			52	29					0	0	0	0	C	66467879	C	C	66467879	2	2	122	1	0	0	0	0	0	0	0	1	5194	1277	45	2		2	EPHA5	4	66467879	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3531904	66467879	124686397	142	21589											
C4orf40	401137	broad.mit.edu	37	chr4	71024438	71024438	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggggcccctgttgcagctGagcctgctgcagaggcacct	6	7	14	14	0	0	2	0	1	0	1	0	2	0	2	4	3	5	6	4	3	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:71024438G>C	uc003hfa.3	+	4	542	c.469G>C	c.(469-471)GAG>CAG	p.E157Q	C4orf40_uc003hfb.3_Missense_Mutation_p.E157Q	NM_214711	NP_999876	Q6MZM9	CD040_HUMAN	hypothetical protein LOC401137 precursor	157	Ala-rich.					extracellular region					0						TGTTGCAGCTGAGCCTGCTGC	0.642													43	11					0	0	0	0	C	71024438	C	C	71024438	3	2	122	1	0	0	0	0	1	0	0	0	2279	1291	45	2	479	2	C4orf40	4	71024438	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4556559	71024438	120129838	143	21590											
SLC4A4	8671	broad.mit.edu	37	chr4	72429528	72429529	+	Frame_Shift_Ins	INS	-	A	A																															gtctgactgcccatactcagINSaaaaagttccaagtattaaa																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:72429528_72429529insA	uc003hfy.2	+	24	3235_3236	c.3118_3119insA	c.(3118-3120)GAAfs	p.E1040fs	SLC4A4_uc010iic.2_Intron|SLC4A4_uc010iib.2_Frame_Shift_Ins_p.E956fs|SLC4A4_uc003hfz.2_Frame_Shift_Ins_p.E1040fs|SLC4A4_uc003hgc.3_Frame_Shift_Ins_p.E996fs|SLC4A4_uc010iid.2_Frame_Shift_Ins_p.E244fs	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	1040	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CCCATACTCAGAAAAAGTTCCA	0.381													---	---	---								A	72429529	A	A	72429528	7	5	122	1	0	1	1	0	0	0	0	0	14720	943	33	0	3329	0	SLC4A4	4	72429528	Frame_Shift_Ins	INS	-	TCGA-CR-6472-01A-11D-1870-08	1405090	72429528	118724748	144	21591											
ADH1C	126	broad.mit.edu	37	chr4	100261734	100261734	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgaagcctaactacatacctCcaaaaatagctcctttccac	14	10	3	14	0	0	1	0	1	0	0	3	1	3	1	5	0	5	1	5	0	7	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:100261734C>T	uc003huu.2	-	9	1047	c.962G>A	c.(961-963)GGA>GAA	p.G321E		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	321					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	CTACATACCTCCAAAAATAGC	0.413									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				92	72					0	0	0	0	T	100261734	T	T	100261734	3	4	122	1	0	0	0	0	1	0	0	0	309	855	30	2	177	2	ADH1C	4	100261734	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	27832206	100261734	90892542	145	21592											
C4orf31	79625	broad.mit.edu	37	chr4	121957931	121957931	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaatgccttccacattctGagacagaagaagtttcccat	12	11	7	11	0	1	4	0	2	1	3	3	5	3	4	3	0	1	1	3	0	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:121957931G>A	uc003idq.1	-	4	1722	c.1195C>T	c.(1195-1197)CAG>TAG	p.Q399*		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	399											0						TCCACATTCTGAGACAGAAGA	0.418													46	41					0	0	0	0	A	121957931	A	A	121957931	4	1	122	1	0	0	0	0	0	1	0	0	2271	1299	45	2	515	2	C4orf31	4	121957931	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	21696197	121957931	69196345	146	21593											
NUDT6	11162	broad.mit.edu	37	chr4	123814217	123814217	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catcttaagcattcttcctgGcaaaaatttatggtgaatga	13	14	7	7	0	2	2	0	2	2	0	3	2	3	2	1	2	1	2	1	2	5	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:123814217G>A	uc003iew.2	-	5	749	c.717C>T	c.(715-717)TGC>TGT	p.C239C	FGF2_uc003iev.1_3'UTR|NUDT6_uc003iex.2_Silent_p.C70C	NM_007083	NP_009014	P53370	NUDT6_HUMAN	nudix-type motif 6 isoform a	239	Nudix hydrolase.					mitochondrion|nucleus	growth factor activity|hydrolase activity				0						ATTCTTCCTGGCAAAAATTTA	0.443													4	81					0	0	0	0	A	123814217	A	A	123814217	2	1	122	1	0	0	0	0	0	0	0	1	10797	1195	42	4		4	NUDT6	4	123814217	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1856286	123814217	67340059	147	21594											
GAB1	2549	broad.mit.edu	37	chr4	144354740	144354740	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacccaggcagattcatcctCtgctactctacctcctccat	8	11	4	18	0	3	1	1	0	2	1	6	1	6	1	5	1	3	2	5	1	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:144354740C>T	uc003ije.2	+	3	823	c.464C>T	c.(463-465)TCT>TTT	p.S155F	GAB1_uc003ijd.2_Missense_Mutation_p.S155F|GAB1_uc011chq.1_Missense_Mutation_p.S52F	NM_002039	NP_002030	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1 isoform b	155					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(2)|lung(1)|skin(1)	4	all_hematologic(180;0.158)					GATTCATCCTCTGCTACTCTA	0.483													46	28					0	0	0	0	T	144354740	T	T	144354740	3	4	122	1	0	0	0	0	1	0	0	0	6182	913	32	2	474	2	GAB1	4	144354740	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	20540523	144354740	46799536	148	21595											
ARHGAP10	79658	broad.mit.edu	37	chr4	148867785	148867785	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagatgtaaaaacatgcaatGaggtggacctggagaattct	15	10	11	5	0	1	3	0	1	1	2	1	5	1	4	1	3	2	2	1	3	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:148867785G>A	uc003ilf.2	+	15	1321	c.1321G>A	c.(1321-1323)GAG>AAG	p.E441K	ARHGAP10_uc003ilg.2_Missense_Mutation_p.E90K|ARHGAP10_uc003ilh.2_Missense_Mutation_p.E22K	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	441	Rho-GAP.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		AACATGCAATGAGGTGGACCT	0.383													12	5					0	0	0	0	A	148867785	A	A	148867785	3	1	122	1	0	0	0	0	1	0	0	0	862	1291	45	2	1379	2	ARHGAP10	4	148867785	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4513045	148867785	42286491	149	21596											
MND1	84057	broad.mit.edu	37	chr4	154315459	154315459	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagcctacagaaaagcattGagaaagctaaaattggccga	18	6	9	8	1	0	2	0	1	0	2	0	4	0	2	2	1	4	2	2	1	7	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:154315459G>A	uc003ink.1	+	5	411	c.322G>A	c.(322-324)GAG>AAG	p.E108K		NM_032117	NP_115493	Q9BWT6	MND1_HUMAN	GAJ protein	108	Potential.				DNA recombination|meiosis	nucleus	DNA binding				0	all_hematologic(180;0.093)					GAAAAGCATTGAGAAAGCTAA	0.353													14	13					0	0	0	0	A	154315459	A	A	154315459	3	1	122	1	0	0	0	0	1	0	0	0	9728	1291	45	2	340	2	MND1	4	154315459	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5447674	154315459	36838817	150	21597											
MND1	84057	broad.mit.edu	37	chr4	154318395	154318395	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcgaaccaggctagcaaaaGagctttcttcacttcgagac	13	8	9	11	2	2	2	1	0	1	2	3	4	2	2	1	1	4	3	1	1	4	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:154318395G>C	uc003ink.1	+	6	465	c.376G>C	c.(376-378)GAG>CAG	p.E126Q		NM_032117	NP_115493	Q9BWT6	MND1_HUMAN	GAJ protein	126	Potential.				DNA recombination|meiosis	nucleus	DNA binding				0	all_hematologic(180;0.093)					GCTAGCAAAAGAGCTTTCTTC	0.358													6	3					0	0	0	0	C	154318395	C	C	154318395	3	2	122	1	0	0	0	0	1	0	0	0	9728	943	33	2	398	2	MND1	4	154318395	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2936	154318395	36835881	151	21598											
LRAT	9227	broad.mit.edu	37	chr4	155665794	155665794	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgggcgttattgtcaaagtgGccagcatccgcgtggacaca	9	9	13	10	3	1	0	1	0	0	0	2	1	2	1	2	3	1	2	2	3	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:155665794G>T	uc003iom.1	+	1	643	c.316G>T	c.(316-318)GCC>TCC	p.A106S	uc003iol.2_Intron|LRAT_uc003ion.1_Missense_Mutation_p.A106S	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	106	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	TGTCAAAGTGGCCAGCATCCG	0.572													9	4					5.4927e-09	5.72005e-09	1	0	T	155665794	T	T	155665794	3	4	122	1	0	0	0	0	1	0	0	0	8980	1203	42	4	318	4	LRAT	4	155665794	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1347399	155665794	35488482	152	21599											
NAF1	92345	broad.mit.edu	37	chr4	164050069	164050069	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaatagtaaggtccaaaatGagaattactatctccagaag	17	10	7	7	0	1	2	0	1	1	2	3	3	2	2	2	1	1	1	2	1	9	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:164050069G>A	uc003iqj.2	-	8	1659	c.1465C>T	c.(1465-1467)CAT>TAT	p.H489Y	NAF1_uc010iqw.1_Intron	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	489					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				GGTCCAAAATGAGAATTACTA	0.264													17	12					0	0	0	0	A	164050069	A	A	164050069	3	1	122	1	0	0	0	0	1	0	0	0	10193	1290	45	2	164	2	NAF1	4	164050069	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8384275	164050069	27104207	153	21600											
NEK1	4750	broad.mit.edu	37	chr4	170428916	170428916	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcagcctcttcacttccttCttgtccttcagaatgattag	7	16	6	12	0	5	2	3	1	2	1	7	2	7	2	3	0	1	0	3	0	2	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr4:170428916C>G	uc003isb.1	-	20	2269	c.1777G>C	c.(1777-1779)GAA>CAA	p.E593Q	NEK1_uc003isc.1_Missense_Mutation_p.E549Q|NEK1_uc003isd.1_Missense_Mutation_p.E621Q|NEK1_uc003ise.1_Missense_Mutation_p.E577Q|NEK1_uc003isf.1_Missense_Mutation_p.E524Q	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	593					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		TCACTTCCTTCTTGTCCTTCA	0.358													30	22					0	0	0	0	G	170428916	G	G	170428916	3	3	122	1	0	0	0	0	1	0	0	0	10375	922	32	2	2059	2	NEK1	4	170428916	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6378847	170428916	20725360	154	21601											
ADAMTS16	170690	broad.mit.edu	37	chr5	5186271	5186271	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccatagaaatgaagaactGaacgtggagaccttggtggt	13	9	12	7	1	0	5	0	2	0	3	1	6	1	5	2	3	2	0	2	3	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:5186271G>C	uc003jdl.2	+	5	1008	c.870G>C	c.(868-870)CTG>CTC	p.L290L	ADAMTS16_uc003jdk.1_Silent_p.L290L|ADAMTS16_uc003jdj.1_Silent_p.L290L	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	290	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ATGAAGAACTGAACGTGGAGA	0.473													38	51					0	0	0	0	C	5186271	C	C	5186271	2	2	122	1	0	0	0	0	0	0	0	1	261	1277	45	2		2	ADAMTS16	5	5186271	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08		5186271	175728989	155	21602											
BASP1	10409	broad.mit.edu	37	chr5	17275436	17275436	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acggaagaggaggggaccccGaaggagagtgagccccaggc	12	1	18	10	2	0	3	0	1	0	2	0	8	0	6	4	6	1	0	4	6	2	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:17275436G>A	uc003jfx.2	+	2	290	c.111G>A	c.(109-111)CCG>CCA	p.P37P		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	37					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						AGGGGACCCCGAAGGAGAGTG	0.647													11	12					0	0	0	0	A	17275436	A	A	17275436	2	1	122	1	0	0	0	0	0	0	0	1	1319	1045	37	1		1	BASP1	5	17275436	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	12089165	17275436	163639824	156	21603											
NPR3	4883	broad.mit.edu	37	chr5	32712159	32712159	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgggactgggaggcggcttCtgccgccgggcactcgcttc	4	7	16	14	5	1	0	0	0	1	0	3	2	1	2	2	5	1	3	2	5	0	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:32712159C>T	uc003jhv.2	+	1	495	c.277C>T	c.(277-279)CTG>TTG	p.L93L	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Silent_p.L93L	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	93	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GAGGCGGCTTCTGCCGCCGGG	0.677													17	41					0	0	0	0	T	32712159	T	T	32712159	2	4	122	1	0	0	0	0	0	0	0	1	10650	912	32	2		2	NPR3	5	32712159	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	15436723	32712159	148203101	157	21604											
ZNF131	7690	broad.mit.edu	37	chr5	43161724	43161724	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacaggtagaaggtattgaaAttgtggaacttcagctgtca	14	11	11	5	0	2	2	2	1	0	1	2	3	2	3	0	3	3	3	0	3	6	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:43161724A>G	uc011cpw.1	+	5	781	c.745A>G	c.(745-747)ATT>GTT	p.I249V	ZNF131_uc010ivl.1_Intron|ZNF131_uc003jnj.3_Intron|ZNF131_uc003jnk.2_Intron|ZNF131_uc003jnn.3_5'UTR|ZNF131_uc003jnl.1_Intron|ZNF131_uc010ivm.1_Intron	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	249						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGGTATTGAAATTGTGGAACT	0.403													23	49					0	0	0	0	G	43161724	G	G	43161724	3	3	122	1	0	0	0	0	1	0	0	0	17788	116	4	5		5	ZNF131	5	43161724	Missense_Mutation	SNP	A	TCGA-CR-6472-01A-11D-1870-08	10449565	43161724	137753536	158	21605											
PDE8B	8622	broad.mit.edu	37	chr5	76715710	76715710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaacaagccaatggcagctGaggtgagtactgctttccat	11	10	10	10	0	1	2	1	2	0	0	2	2	2	2	2	2	5	4	2	2	4	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:76715710G>A	uc003kfa.2	+	19	2293	c.2248G>A	c.(2248-2250)GAG>AAG	p.E750K	PDE8B_uc003kfb.2_Missense_Mutation_p.E730K|PDE8B_uc003kfc.2_Missense_Mutation_p.E695K|PDE8B_uc003kfd.2_Missense_Mutation_p.E703K|PDE8B_uc003kfe.2_Missense_Mutation_p.E653K	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	750	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		AATGGCAGCTGAGGTGAGTAC	0.448													17	33					0	0	0	0	A	76715710	A	A	76715710	3	1	122	1	0	0	0	0	1	0	0	0	11708	1291	45	2	2322	2	PDE8B	5	76715710	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	33553986	76715710	104199550	159	21606											
RHOBTB3	22836	broad.mit.edu	37	chr5	95087996	95087996	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagacaagtgaaaaaatgaaGaaaagaaaaatgagcaactc	25	4	8	4	0	0	6	0	3	0	3	1	6	0	6	0	0	2	1	0	0	11	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:95087996G>A	uc003klm.2	+	5	1161	c.624G>A	c.(622-624)AAG>AAA	p.K208K	RHOBTB3_uc003klk.1_Silent_p.K2K	NM_014899	NP_055714	O94955	RHBT3_HUMAN	rho-related BTB domain containing 3	208					retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		AAAAAATGAAGAAAAGAAAAA	0.313													46	96					0	0	0	0	A	95087996	A	A	95087996	2	1	122	1	0	0	0	0	0	0	0	1	13400	933	33	2		2	RHOBTB3	5	95087996	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	18372286	95087996	85827264	160	21607											
PJA2	9867	broad.mit.edu	37	chr5	108691708	108691708	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagcaactcctagtccatCtgcaaagccatcaaataggc	13	9	6	13	0	3	0	2	0	1	0	5	0	5	0	3	1	4	2	3	1	5	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:108691708C>T	uc003kos.3	-	7	1892	c.1672G>A	c.(1672-1674)GAT>AAT	p.D558N		NM_014819	NP_055634	O43164	PJA2_HUMAN	praja 2, RING-H2 motif containing	558	Interaction with PRKAR1A, PRKAR2A and PRKAR2B.				long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		CCTAGTCCATCTGCAAAGCCA	0.383													39	78					0	0	0	0	T	108691708	T	T	108691708	3	4	122	1	0	0	0	0	1	0	0	0	12017	913	32	2	470	2	PJA2	5	108691708	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	13603712	108691708	72223552	161	21608											
APC	324	broad.mit.edu	37	chr5	112137026	112137026	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacatgatgctgagcggcaGaatgaaggtcaaggagtggg	12	7	16	6	1	2	4	2	3	0	1	2	5	2	5	0	4	2	2	0	4	3	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:112137026G>C	uc010jby.2	+	8	1160	c.780G>C	c.(778-780)CAG>CAC	p.Q260H	APC_uc011cvt.1_Missense_Mutation_p.Q242H|APC_uc003kpz.3_Missense_Mutation_p.Q260H|APC_uc003kpy.3_Missense_Mutation_p.Q260H|APC_uc010jbz.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	260	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CTGAGCGGCAGAATGAAGGTC	0.358		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			15	35					0	0	0	0	C	112137026	C	C	112137026	3	2	122	1	0	0	0	0	1	0	0	0	763	933	33	2	806	2	APC	5	112137026	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3445318	112137026	68778234	162	21609											
FAM170A	340069	broad.mit.edu	37	chr5	118968548	118968548	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttctacctccgaatactgctCctgcgtttcttcttcacgca	6	15	5	15	3	4	0	1	0	3	0	6	1	6	0	3	0	4	3	3	0	3	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:118968548C>G	uc003ksm.2	+	2	386	c.176C>G	c.(175-177)TCC>TGC	p.S59C	FAM170A_uc003ksl.2_Missense_Mutation_p.S59C|FAM170A_uc003ksn.2_Missense_Mutation_p.S59C|FAM170A_uc003kso.2_Intron	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	59						intracellular	zinc ion binding			skin(1)	1						GAATACTGCTCCTGCGTTTCT	0.547													33	61					0	0	0	0	G	118968548	G	G	118968548	3	3	122	1	0	0	0	0	1	0	0	0	5517	855	30	2	182	2	FAM170A	5	118968548	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6831522	118968548	61946712	163	21610											
ALDH7A1	501	broad.mit.edu	37	chr5	125918566	125918566	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagaaggcaagataggtcctCcaatcatccttgataaacca	15	8	7	11	0	1	3	1	1	0	2	4	3	4	3	4	2	1	1	4	2	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:125918566C>T	uc003ktx.2	-	5	686	c.494G>A	c.(493-495)GGA>GAA	p.G165E	ALDH7A1_uc003kty.2_RNA|ALDH7A1_uc011cxa.1_Missense_Mutation_p.G192E|ALDH7A1_uc003ktz.2_Missense_Mutation_p.G192E	NM_001182	NP_001173	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	165					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			kidney(2)|ovary(1)	3		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	GATAGGTCCTCCAATCATCCT	0.388													30	27					0	0	0	0	T	125918566	T	T	125918566	3	4	122	1	0	0	0	0	1	0	0	0	504	855	30	2	1181	2	ALDH7A1	5	125918566	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6950018	125918566	54996694	164	21611											
AFF4	27125	broad.mit.edu	37	chr5	132232368	132232368	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctctcactttcatctgaatCtgaggatgaggtatctgttt	8	16	9	8	0	5	3	2	3	4	0	6	4	5	4	0	2	0	3	0	2	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:132232368C>G	uc003kyd.2	-	11	2362	c.1954G>C	c.(1954-1956)GAT>CAT	p.D652H	AFF4_uc011cxk.1_Missense_Mutation_p.D330H|AFF4_uc003kye.1_Missense_Mutation_p.D652H	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	652					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCATCTGAATCTGAGGATGAG	0.438													38	73					0	0	0	0	G	132232368	G	G	132232368	3	3	122	1	0	0	0	0	1	0	0	0	359	913	32	2	1581	2	AFF4	5	132232368	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6313802	132232368	48682892	165	21612											
PCDHA5	56143	broad.mit.edu	37	chr5	140201501	140201501	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaaccttcgttggccgcatCgcgcaggacctagggctgga	7	7	15	12	4	0	0	0	0	0	0	2	3	0	3	3	5	1	4	3	5	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:140201501C>T	uc003lhl.2	+	1	141	c.141C>T	c.(139-141)ATC>ATT	p.I47I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.I47I|PCDHA5_uc003lhj.1_Silent_p.I47I	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	47	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGGCCGCATCGCGCAGGACC	0.647													46	56					0	0	0	0	T	140201501	T	T	140201501	2	4	122	1	0	0	0	0	0	0	0	1	11581	874	31	1		1	PCDHA5	5	140201501	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	7969133	140201501	40713759	166	21613											
PCDHA5	56143	broad.mit.edu	37	chr5	140201580	140201580	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaagggccgcggggaccttCtggaggtaaatctgcagaat	10	7	14	10	2	2	1	0	0	2	1	2	3	2	3	3	5	1	2	3	5	4	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:140201580C>T	uc003lhl.2	+	1	220	c.220C>T	c.(220-222)CTG>TTG	p.L74L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.L74L|PCDHA5_uc003lhj.1_Silent_p.L74L	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	74	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding	p.Q49fs*50(1)		ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGGACCTTCTGGAGGTAAA	0.647													67	130					0	0	0	0	T	140201580	T	T	140201580	2	4	122	1	0	0	0	0	0	0	0	1	11581	912	32	2		2	PCDHA5	5	140201580	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	79	140201580	40713680	167	21614											
PCDHA6	56142	broad.mit.edu	37	chr5	140209500	140209500	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctacaacgcgtggctttcGtatgagctgcagcccccggc	6	8	13	14	4	0	1	0	1	0	0	1	1	0	1	2	3	5	5	2	3	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:140209500G>A	uc003lho.2	+	1	1851	c.1824G>A	c.(1822-1824)TCG>TCA	p.S608S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.S608S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	608	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGCTTTCGTATGAGCTGC	0.657													21	46					0	0	0	0	A	140209500	A	A	140209500	2	1	122	1	0	0	0	0	0	0	0	1	11582	1132	40	1		1	PCDHA6	5	140209500	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	7920	140209500	40705760	168	21615											
PCDHB6	56130	broad.mit.edu	37	chr5	140532108	140532108	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgtgtctgacgggaggctCagaaacaaatgagttcaagt	12	9	14	6	1	3	3	2	2	1	1	3	4	3	4	0	3	1	2	0	3	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:140532108C>G	uc003lir.2	+	1	2270	c.2270C>G	c.(2269-2271)TCA>TGA	p.S757*	PCDHB6_uc011dah.1_Nonsense_Mutation_p.S621*	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	757	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGGGAGGCTCAGAAACAAAT	0.562													67	101					0	0	0	0	G	140532108	G	G	140532108	4	3	122	1	0	0	0	0	0	1	0	0	11600	838	29	2	2272	2	PCDHB6	5	140532108	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	322608	140532108	40383152	169	21616											
PCDHGA1	56114	broad.mit.edu	37	chr5	140710402	140710402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcgtaggcaacatcgccaagGacctagggctgcaaccccag	11	5	11	14	2	0	0	0	0	0	0	2	1	0	1	4	3	3	4	4	3	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:140710402G>A	uc003lji.1	+	1	151	c.151G>A	c.(151-153)GAC>AAC	p.D51N	PCDHGA1_uc011dan.1_Missense_Mutation_p.D51N	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	51	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCGCCAAGGACCTAGGGCT	0.557													31	89					0	0	0	0	A	140710402	A	A	140710402	3	1	122	1	0	0	0	0	1	0	0	0	11604	1174	41	2	153	2	PCDHGA1	5	140710402	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	178294	140710402	40204858	170	21617											
PCDHGA1	56114	broad.mit.edu	37	chr5	140711728	140711728	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatcacttactccctaataGaggacactatccagggggca	14	8	8	11	0	1	1	1	0	0	1	3	2	3	2	2	3	1	1	2	3	5	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:140711728G>A	uc003lji.1	+	1	1477	c.1477G>A	c.(1477-1479)GAG>AAG	p.E493K	PCDHGA1_uc011dan.1_Missense_Mutation_p.E493K	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	493	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCCTAATAGAGGACACTAT	0.537													53	135					0	0	0	0	A	140711728	A	A	140711728	3	1	122	1	0	0	0	0	1	0	0	0	11604	943	33	2	1479	2	PCDHGA1	5	140711728	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1326	140711728	40203532	171	21618											
PCDHGA9	56107	broad.mit.edu	37	chr5	140782700	140782700	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggagccccgggagctggcgGagcgccgagtccgcatcgtc	5	5	17	14	6	0	0	0	0	0	0	3	4	1	3	4	4	3	2	4	4	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:140782700G>T	uc003lkh.1	+	1	181	c.181G>T	c.(181-183)GAG>TAG	p.E61*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Nonsense_Mutation_p.E61*	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	61	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGCTGGCGGAGCGCCGAGT	0.607													53	86					7.41606e-26	8.14084e-26	1	0	T	140782700	T	T	140782700	4	4	122	1	0	0	0	0	0	1	0	0	11615	1175	41	2	183	2	PCDHGA9	5	140782700	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	70972	140782700	40132560	172	21619											
PCDHGA12	26025	broad.mit.edu	37	chr5	140812070	140812070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggagctggctccccgctccGcagagcccggctacctggtg	4	7	14	16	3	0	1	0	0	0	1	2	2	2	2	5	4	3	5	5	4	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:140812070G>A	uc003lkt.1	+	1	1913	c.1744G>A	c.(1744-1746)GCA>ACA	p.A582T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.A582T	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	582	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCCGCTCCGCAGAGCCCGG	0.682													58	105					0	0	0	0	A	140812070	A	A	140812070	3	1	122	1	0	0	0	0	1	0	0	0	11607	1087	38	1	1746	1	PCDHGA12	5	140812070	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	29370	140812070	40103190	173	21620											
ANXA6	309	broad.mit.edu	37	chr5	150512081	150512081	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtccccagacagctcccctCggatgctggcttcaatcggc	7	8	10	16	2	1	1	1	0	0	1	5	2	3	2	4	3	2	3	4	3	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:150512081C>T	uc003ltl.1	-	10	844	c.692G>A	c.(691-693)CGA>CAA	p.R231Q	ANXA6_uc011dcp.1_Missense_Mutation_p.R199Q|ANXA6_uc003ltm.1_Missense_Mutation_p.R231Q|ANXA6_uc003ltn.1_Intron|ANXA6_uc003lto.1_Intron	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	231	Annexin 3.					melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding	p.R231Q(1)			0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGCTCCCCTCGGATGCTGGC	0.552													7	22					0	0	0	0	T	150512081	T	T	150512081	3	4	122	1	0	0	0	0	1	0	0	0	722	884	31	1	1397	1	ANXA6	5	150512081	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	9700011	150512081	30403179	174	21621											
N4BP3	23138	broad.mit.edu	37	chr5	177547335	177547335	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcccctgagccccgggcccCgggccagccaggcccgggca	4	1	15	21	4	0	1	0	1	0	0	0	1	0	1	9	4	2	1	9	4	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr5:177547335C>T	uc003mik.1	+	3	734	c.487C>T	c.(487-489)CGG>TGG	p.R163W	N4BP3_uc003mil.1_5'Flank	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	163				R -> Q (in Ref. 3; AAH53323).		cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCGGGCCCCGGGCCAGCCA	0.706													6	9					0	0	0	0	T	177547335	T	T	177547335	3	4	122	1	0	0	0	0	1	0	0	0	10166	643	23	1	493	1	N4BP3	5	177547335	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	27035254	177547335	3367925	175	21622											
JARID2	3720	broad.mit.edu	37	chr6	15410497	15410497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagggattaggaccagcatCagaacagtcagagaatgaaa	18	6	11	6	0	2	3	2	1	0	2	2	6	2	5	1	2	2	1	1	2	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:15410497C>T	uc003nbj.2	+	3	468	c.224C>T	c.(223-225)TCA>TTA	p.S75L	JARID2_uc011diu.1_5'UTR|JARID2_uc011div.1_5'UTR|JARID2_uc011diw.1_Missense_Mutation_p.S37L	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	75					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				GGACCAGCATCAGAACAGTCA	0.463													114	27					0	0	0	0	T	15410497	T	T	15410497	3	4	122	1	0	0	0	0	1	0	0	0	7984	838	29	2	234	2	JARID2	6	15410497	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08		15410497	155704570	176	21623											
LRRC16A	55604	broad.mit.edu	37	chr6	25450578	25450578	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtttcaggtggattttctCagatgtatgcctgtgtttgt	6	19	11	5	0	2	1	2	0	1	1	3	2	2	2	1	2	1	3	1	2	1	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:25450578C>T	uc011djw.1	+	7	857	c.481C>T	c.(481-483)CAG>TAG	p.Q161*	LRRC16A_uc010jpx.2_Nonsense_Mutation_p.Q161*|LRRC16A_uc010jpy.2_Nonsense_Mutation_p.Q161*|LRRC16A_uc003nez.1_5'UTR	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	161					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						TGGATTTTCTCAGATGTATGC	0.378													17	14					0	0	0	0	T	25450578	T	T	25450578	4	4	122	1	0	0	0	0	0	1	0	0	9021	827	29	2	507	2	LRRC16A	6	25450578	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	10040081	25450578	145664489	177	21624											
OR11A1	26531	broad.mit.edu	37	chr6	29394966	29394966	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatctaccacaaatccagaGagccaggttgtgaccaccag	13	6	8	14	0	1	2	0	1	1	1	2	3	2	2	6	1	2	1	6	1	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:29394966G>C	uc003nmg.2	-	1	544	c.453C>G	c.(451-453)CTC>CTG	p.L151L		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CAAATCCAGAGAGCCAGGTTG	0.547													17	19					0	0	0	0	C	29394966	C	C	29394966	2	2	122	1	0	0	0	0	0	0	0	1	10978	929	33	2		2	OR11A1	6	29394966	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3944388	29394966	141720101	178	21625											
TAP1	6890	broad.mit.edu	37	chr6	32815407	32815407	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccataggcaatattttcttGaagacttcttccaaatacct	12	14	5	10	0	2	2	0	1	2	1	3	2	3	2	3	1	1	1	3	1	6	8			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:32815407G>A	uc003ocg.2	-	9	2121	c.1966C>T	c.(1966-1968)CAA>TAA	p.Q656*	PSMB8_uc003ocf.2_5'Flank|TAP1_uc011dqi.1_Nonsense_Mutation_p.Q395*	NM_000593	NP_000584	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family	656	Cytoplasmic (Potential).|ABC transporter.				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1						ATATTTTCTTGAAGACTTCTT	0.468													26	15					0	0	0	0	A	32815407	A	A	32815407	4	1	122	1	0	0	0	0	0	1	0	0	15616	1299	45	2	472	2	TAP1	6	32815407	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3420441	32815407	138299660	179	21626											
ITPR3	3710	broad.mit.edu	37	chr6	33660555	33660555	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacctcctgttcttcttcatCgtcatcatcattgtgctgaa	7	16	6	12	1	6	1	4	1	2	0	8	2	7	1	2	0	1	2	2	0	1	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:33660555C>T	uc011drk.1	+	55	7728	c.7509C>T	c.(7507-7509)ATC>ATT	p.I2503I	ITPR3_uc003oey.2_Silent_p.I590I	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2503	Helical; (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TCTTCTTCATCGTCATCATCA	0.537													32	35					0	0	0	0	T	33660555	T	T	33660555	2	4	122	1	0	0	0	0	0	0	0	1	7961	874	31	1		1	ITPR3	6	33660555	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	845148	33660555	137454512	180	21627											
KCNK5	8645	broad.mit.edu	37	chr6	39159321	39159321	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgacgtccttggaggctgtgCtccccttcacctgcagggcc	4	10	12	15	1	1	1	1	1	0	0	3	2	3	2	5	3	2	3	5	3	0	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:39159321C>T	uc003oon.2	-	5	1209	c.845G>A	c.(844-846)AGC>AAC	p.S282N		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	282	Cytoplasmic (Potential).				excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						GGAGGCTGTGCTCCCCTTCAC	0.547													71	48					0	0	0	0	T	39159321	T	T	39159321	3	4	122	1	0	0	0	0	1	0	0	0	8108	797	28	4	658	4	KCNK5	6	39159321	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	5498766	39159321	131955746	181	21628											
DAAM2	23500	broad.mit.edu	37	chr6	39846340	39846340	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggggacaagtggcagagctGgtagcccagctcagtgaact	10	6	15	10	1	1	2	1	1	0	1	1	3	1	3	1	4	4	4	1	4	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:39846340G>C	uc003oow.2	+	13	1677	c.1521G>C	c.(1519-1521)CTG>CTC	p.L507L	DAAM2_uc010jxc.2_Silent_p.L507L|DAAM2_uc003oox.2_Silent_p.L507L	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	507	Potential.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					TGGCAGAGCTGGTAGCCCAGC	0.582													3	1					0	0	0	0	C	39846340	C	C	39846340	2	2	122	1	0	0	0	0	0	0	0	1	4233	1335	47	4		4	DAAM2	6	39846340	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	687019	39846340	131268727	182	21629											
GCM1	8521	broad.mit.edu	37	chr6	52993467	52993467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagtagactccggaggcaGaaggaggaagcaggtctcca	13	4	15	9	1	1	3	0	0	1	3	3	6	2	6	2	5	1	3	2	5	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:52993467G>A	uc003pbp.2	-	6	1057	c.848C>T	c.(847-849)TCT>TTT	p.S283F		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	283						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					TCCGGAGGCAGAAGGAGGAAG	0.473													22	48					0	0	0	0	A	52993467	A	A	52993467	3	1	122	1	0	0	0	0	1	0	0	0	6332	942	33	2	466	2	GCM1	6	52993467	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	13147127	52993467	118121600	183	21630											
IBTK	25998	broad.mit.edu	37	chr6	82927733	82927733	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atctccctctaaatccttctCcatcttgcgtaacaaataga	12	13	3	13	1	4	1	0	0	4	1	7	1	5	1	3	0	2	1	3	0	5	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:82927733C>G	uc003pjl.1	-	10	1897	c.1370G>C	c.(1369-1371)GGA>GCA	p.G457A	IBTK_uc011dyv.1_Missense_Mutation_p.G457A|IBTK_uc011dyw.1_Missense_Mutation_p.G457A|IBTK_uc010kbi.1_Missense_Mutation_p.G151A|IBTK_uc003pjm.2_Missense_Mutation_p.G457A	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	457					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		AAATCCTTCTCCATCTTGCGT	0.353													21	32					0	0	0	0	G	82927733	G	G	82927733	3	3	122	1	0	0	0	0	1	0	0	0	7515	855	30	2	2771	2	IBTK	6	82927733	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	29934266	82927733	88187334	184	21631											
DOPEY1	23033	broad.mit.edu	37	chr6	83830475	83830475	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaggatctaaagccttttcGcattttaatcagtttactgg	10	15	8	8	1	2	0	1	0	1	0	3	1	2	1	1	2	2	3	1	2	4	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:83830475G>A	uc003pjs.1	+	10	1324	c.1064G>A	c.(1063-1065)CGC>CAC	p.R355H	DOPEY1_uc011dyy.1_Missense_Mutation_p.R346H|DOPEY1_uc010kbl.1_Missense_Mutation_p.R346H	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	355					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAGCCTTTTCGCATTTTAATC	0.368													12	45					0	0	0	0	A	83830475	A	A	83830475	3	1	122	1	0	0	0	0	1	0	0	0	4729	1087	38	1	1094	1	DOPEY1	6	83830475	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	902742	83830475	87284592	185	21632											
SFRS18	25957	broad.mit.edu	37	chr6	99856061	99856061	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgttgttgttccattctttCtttctccaatttcttctgct	4	22	4	11	1	5	0	0	0	5	0	7	0	6	0	2	0	1	4	2	0	1	8			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:99856061C>T	uc003ppo.3	-	7	988	c.760G>A	c.(760-762)GAA>AAA	p.E254K	SFRS18_uc003ppp.3_Missense_Mutation_p.E254K|SFRS18_uc011eag.1_Missense_Mutation_p.E254K|SFRS18_uc003ppr.2_Missense_Mutation_p.E254K	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	254	Potential.					nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)		TCCATTCTTTCTTTCTCCAAT	0.443													52	68					0	0	0	0	T	99856061	T	T	99856061	3	4	122	1	0	0	0	0	1	0	0	0	14239	922	32	2	1681	2	SFRS18	6	99856061	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	16025586	99856061	71259006	186	21633											
SLC22A16	85413	broad.mit.edu	37	chr6	110778028	110778028	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcaccgtaacataatctttCtggcctgaagacaacagggc	12	9	9	11	1	2	2	0	1	2	1	2	2	2	2	2	2	3	2	2	2	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:110778028C>G	uc003puf.2	-	2	313	c.246G>C	c.(244-246)CAG>CAC	p.Q82H	SLC22A16_uc003pue.2_Intron|SLC22A16_uc003pug.2_Missense_Mutation_p.Q82H	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	82					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CATAATCTTTCTGGCCTGAAG	0.488													64	128					0	0	0	0	G	110778028	G	G	110778028	3	3	122	1	0	0	0	0	1	0	0	0	14512	912	32	2	1515	2	SLC22A16	6	110778028	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	10921967	110778028	60337039	187	21634											
GTF3C6	112495	broad.mit.edu	37	chr6	111288781	111288781	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaacatgatttgtaactttCtacatgaaaatgaagacgaa	17	11	6	7	1	1	4	0	3	1	1	1	5	1	4	1	0	3	1	1	0	7	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:111288781C>G	uc003pum.2	+	6	640	c.430C>G	c.(430-432)CTA>GTA	p.L144V		NM_138408	NP_612417	Q969F1	TF3C6_HUMAN	general transcription factor IIIC, polypeptide	144						transcription factor TFIIIC complex	DNA binding|protein binding				0		all_cancers(87;0.00328)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|Colorectal(196;0.0466)|all_epithelial(87;0.0575)		OV - Ovarian serous cystadenocarcinoma(136;0.105)|all cancers(137;0.179)|Epithelial(106;0.186)		TTGTAACTTTCTACATGAAAA	0.393													62	121					0	0	0	0	G	111288781	G	G	111288781	3	3	122	1	0	0	0	0	1	0	0	0	6916	912	32	2	452	2	GTF3C6	6	111288781	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	510753	111288781	59826286	188	21635											
TSPYL1	7259	broad.mit.edu	37	chr6	116599934	116599934	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccccctgcgccatataattgGagtagaaagagacaccactc	13	7	8	13	1	0	2	0	0	0	2	1	4	0	3	4	1	1	1	4	1	4	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:116599934G>C	uc003pwp.3	-	1	1347	c.1060C>G	c.(1060-1062)CCA>GCA	p.P354A	DSE_uc011ebf.1_Intron|DSE_uc003pwq.1_5'Flank|DSE_uc003pwr.2_5'Flank|DSE_uc003pws.2_5'Flank	NM_003309	NP_003300	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	354					nucleosome assembly	nucleolus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		CATATAATTGGAGTAGAAAGA	0.473													43	98					0	0	0	0	C	116599934	C	C	116599934	3	2	122	1	0	0	0	0	1	0	0	0	16726	1174	41	2	257	2	TSPYL1	6	116599934	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5311153	116599934	54515133	189	21636											
GPRC6A	222545	broad.mit.edu	37	chr6	117150061	117150061	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	catgaatagcaaacaaacctCcaattatgatatgtcccgga	16	9	6	10	1	0	2	0	2	0	0	2	3	2	3	3	1	3	1	3	1	7	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:117150061C>G	uc003pxj.1	-	1	138	c.116G>C	c.(115-117)GGA>GCA	p.G39A	GPRC6A_uc003pxk.1_Missense_Mutation_p.G39A|GPRC6A_uc003pxl.1_Missense_Mutation_p.G39A	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	39	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AAACAAACCTCCAATTATGAT	0.433													22	33					0	0	0	0	G	117150061	G	G	117150061	3	3	122	1	0	0	0	0	1	0	0	0	6767	855	30	2	2688	2	GPRC6A	6	117150061	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	550127	117150061	53965006	190	21637											
TRDN	10345	broad.mit.edu	37	chr6	123869710	123869710	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtggtttcctccatagcatCacgtaccagttttaaaggat	10	13	8	10	2	1	0	1	0	0	0	3	1	3	1	3	2	2	4	3	2	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:123869710C>T	uc003pzj.1	-	3	302	c.280G>A	c.(280-282)GAT>AAT	p.D94N	TRDN_uc003pzk.1_Missense_Mutation_p.D94N|TRDN_uc003pzl.1_Missense_Mutation_p.D94N|TRDN_uc010ken.2_Missense_Mutation_p.D94N|TRDN_uc010keo.1_Missense_Mutation_p.D94N	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	94	Lumenal.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		TCCATAGCATCACGTACCAGT	0.353													4	4					0	0	0	0	T	123869710	T	T	123869710	3	4	122	1	0	0	0	0	1	0	0	0	16535	826	29	2	2065	2	TRDN	6	123869710	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6719649	123869710	47245357	191	21638											
ENPP3	5169	broad.mit.edu	37	chr6	131999049	131999049	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgaagaacctgattcctCtggacatgcaggtggaccag	10	11	11	9	0	1	3	0	2	1	1	2	5	2	5	3	3	2	1	3	3	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:131999049C>G	uc003qcu.3	+	12	1327	c.980C>G	c.(979-981)TCT>TGT	p.S327C	ENPP3_uc010kfo.1_RNA|ENPP3_uc010kfp.1_RNA|ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.S327C	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	327	Extracellular (Potential).|Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CCTGATTCCTCTGGACATGCA	0.348													18	40					0	0	0	0	G	131999049	G	G	131999049	3	3	122	1	0	0	0	0	1	0	0	0	5155	913	32	2	1022	2	ENPP3	6	131999049	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	8129339	131999049	39116018	192	21639											
BCLAF1	9774	broad.mit.edu	37	chr6	136599330	136599330	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taggtggtgtagcaataggtGaaggactatggggtgatcta	11	11	16	3	0	1	2	0	2	1	0	1	3	1	3	0	6	1	2	0	6	7	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:136599330G>A	uc003qgx.1	-	4	942	c.689C>T	c.(688-690)TCA>TTA	p.S230L	BCLAF1_uc003qgw.1_Missense_Mutation_p.S230L|BCLAF1_uc003qgy.1_Missense_Mutation_p.S228L|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.S228L	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	230					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGCAATAGGTGAAGGACTATG	0.433													41	125					0	0	0	0	A	136599330	A	A	136599330	3	1	122	1	0	0	0	0	1	0	0	0	1385	1294	45	2	2113	2	BCLAF1	6	136599330	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4600281	136599330	34515737	193	21640											
SLC35D3	340146	broad.mit.edu	37	chr6	137245833	137245833	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaggagttacccagtccttGagaaggaggtgcatgtacgt	10	9	14	8	2	0	1	0	1	0	1	1	5	1	3	2	3	3	3	2	3	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:137245833G>C	uc003qhe.2	+	2	1415	c.1250G>C	c.(1249-1251)TGA>TCA	p.*417S		NM_001008783	NP_001008783	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	417					carbohydrate transport	integral to membrane				ovary(1)|central_nervous_system(1)	2	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		CCCAGTCCTTGAGAAGGAGGT	0.408													25	34					0	0	0	0	C	137245833	C	C	137245833	4	2	122	1	0	0	0	0	0	0	0	0	14647	1285	45	2	1256	2	SLC35D3	6	137245833	Nonstop_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	646503	137245833	33869234	194	21641											
PERP	64065	broad.mit.edu	37	chr6	138428475	138428475	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggccaggccgcagcggatCatgttgacgggcggcgcggg	6	4	19	12	6	1	1	1	1	0	0	1	2	1	2	2	6	1	2	2	6	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:138428475C>A	uc003qht.2	-	1	186	c.3G>T	c.(1-3)ATG>ATT	p.M1I		NM_022121	NP_071404	Q96FX8	PERP_HUMAN	PERP, TP53 apoptosis effector	1					apoptosis|cell adhesion	desmosome|Golgi apparatus|integral to membrane|nucleus					0	Breast(32;0.0799)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000878)|OV - Ovarian serous cystadenocarcinoma(155;0.000997)		CGCAGCGGATCATGTTGACGG	0.582													20	35					2.39187e-15	2.54567e-15	1	0	A	138428475	A	A	138428475	3	1	122	1	0	0	0	0	1	0	0	0	11786	826	29	2	590	2	PERP	6	138428475	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1182642	138428475	32686592	195	21642											
SHPRH	257218	broad.mit.edu	37	chr6	146264599	146264599	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaggtggtacatcactatCagcatgatttagagattcag	14	11	10	6	0	3	3	3	1	0	2	3	4	3	3	0	2	2	2	0	2	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:146264599C>T	uc003qlf.2	-	9	2317	c.1918G>A	c.(1918-1920)GAT>AAT	p.D640N	SHPRH_uc003qld.2_Missense_Mutation_p.D640N|SHPRH_uc003qle.2_Missense_Mutation_p.D640N|SHPRH_uc003qlg.1_Missense_Mutation_p.D196N|SHPRH_uc003qlj.1_Missense_Mutation_p.D529N	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	640					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		ACATCACTATCAGCATGATTT	0.393													42	90					0	0	0	0	T	146264599	T	T	146264599	3	4	122	1	0	0	0	0	1	0	0	0	14356	826	29	2	3265	2	SHPRH	6	146264599	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	7836124	146264599	24850468	196	21643											
NUP43	348995	broad.mit.edu	37	chr6	150052833	150052833	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcttcagagcaggtaaaaaGatgttctgggttggatgggt	11	12	14	4	0	3	2	1	0	2	2	3	3	3	3	0	4	1	4	0	4	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:150052833G>C	uc003qmz.2	-	7	886	c.829C>G	c.(829-831)CTT>GTT	p.L277V	NUP43_uc003qmx.3_RNA|NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Missense_Mutation_p.L181V	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	277	WD 6.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		CAGGTAAAAAGATGTTCTGGG	0.423													15	27					0	0	0	0	C	150052833	C	C	150052833	3	2	122	1	0	0	0	0	1	0	0	0	10819	942	33	2	321	2	NUP43	6	150052833	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3788234	150052833	21062234	197	21644											
PLEKHG1	57480	broad.mit.edu	37	chr6	151152198	151152198	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccctttgggtcatccataGagttgactattgatgacata	10	14	8	9	0	1	4	1	3	0	1	3	4	3	4	2	1	0	1	2	1	3	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:151152198G>C	uc003qny.1	+	16	2263	c.1951G>C	c.(1951-1953)GAG>CAG	p.E651Q	PLEKHG1_uc011eel.1_Missense_Mutation_p.E691Q|PLEKHG1_uc011eem.1_Missense_Mutation_p.E710Q|PLEKHG1_uc003qnz.2_Missense_Mutation_p.E651Q	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	651					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GTCATCCATAGAGTTGACTAT	0.453													12	18					0	0	0	0	C	151152198	C	C	151152198	3	2	122	1	0	0	0	0	1	0	0	0	12123	943	33	2	2005	2	PLEKHG1	6	151152198	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1099365	151152198	19962869	198	21645											
SYNE1	23345	broad.mit.edu	37	chr6	152644705	152644705	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccatcctggagcatgctcagGgtttgctgccgcagcatgcc	6	9	12	14	1	1	0	1	0	0	0	2	1	2	1	4	2	6	6	4	2	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:152644705G>C	uc010kiw.2	-	82	16427	c.15825C>G	c.(15823-15825)ACC>ACG	p.T5275T	SYNE1_uc003qot.3_Silent_p.T5204T|SYNE1_uc003qou.3_Silent_p.T5275T|SYNE1_uc010kiz.2_Silent_p.T1030T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5275	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCATGCTCAGGGTTTGCTGCC	0.567										HNSCC(10;0.0054)			26	46					0	0	0	0	C	152644705	C	C	152644705	2	2	122	1	0	0	0	0	0	0	0	1	15511	1219	43	4		4	SYNE1	6	152644705	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1492507	152644705	18470362	199	21646											
C6orf120	387263	broad.mit.edu	37	chr6	170102948	170102948	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggagagcgagttcgagatGaaggtgtactacgacggcac	11	7	15	8	4	0	3	0	1	0	2	1	7	0	3	0	3	3	3	0	3	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:170102948G>A	uc003qxb.2	+	1	692	c.393G>A	c.(391-393)ATG>ATA	p.M131I	WDR27_uc010kkw.1_5'Flank|WDR27_uc003qwx.2_5'Flank|WDR27_uc003qwy.2_5'Flank|WDR27_uc011egw.1_5'Flank|WDR27_uc010kkx.2_5'Flank|C6orf120_uc011egx.1_Missense_Mutation_p.M150I	NM_001029863	NP_001025034	Q7Z4R8	CF120_HUMAN	hypothetical protein LOC387263 precursor	131						extracellular region					0		Breast(66;0.000338)		OV - Ovarian serous cystadenocarcinoma(33;9.65e-22)|BRCA - Breast invasive adenocarcinoma(81;1.29e-07)|GBM - Glioblastoma multiforme(31;0.0015)		AGTTCGAGATGAAGGTGTACT	0.711													10	24					0	0	0	0	A	170102948	A	A	170102948	3	1	122	1	0	0	0	0	1	0	0	0	2334	1290	45	2	395	2	C6orf120	6	170102948	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	17458243	170102948	1012119	200	21647											
FAM120B	84498	broad.mit.edu	37	chr6	170626882	170626882	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatatgttcttcatcccctCagggctagctgtgtttacac	9	14	7	11	0	3	0	2	0	1	0	4	0	4	0	2	1	2	4	2	1	4	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr6:170626882C>G	uc003qxp.2	+	2	512	c.404C>G	c.(403-405)TCA>TGA	p.S135*	FAM120B_uc003qxo.1_Nonsense_Mutation_p.S135*|FAM120B_uc011ehd.1_Intron	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	135					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		TTCATCCCCTCAGGGCTAGCT	0.458													36	67					0	0	0	0	G	170626882	G	G	170626882	4	3	122	1	0	0	0	0	0	1	0	0	5445	838	29	2	406	2	FAM120B	6	170626882	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	523934	170626882	488185	201	21648											
SDK1	221935	broad.mit.edu	37	chr7	4247913	4247913	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcaggggcgcacccaccaGgccggtaggaggaaggcggg	9	1	19	12	3	0	0	0	0	0	0	0	2	0	2	3	8	1	3	3	8	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:4247913G>A	uc003smx.2	+	37	5536	c.5397G>A	c.(5395-5397)CAG>CAA	p.Q1799Q	SDK1_uc010kso.2_Silent_p.Q1055Q|SDK1_uc003smy.2_Silent_p.Q286Q	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1799					cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GCACCCACCAGGCCGGTAGGA	0.627													8	26					0	0	0	0	A	4247913	A	A	4247913	2	1	122	1	0	0	0	0	0	0	0	1	14033	991	35	4		4	SDK1	7	4247913	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08		4247913	154890750	202	21649											
RADIL	55698	broad.mit.edu	37	chr7	4862113	4862113	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agctcgatggagttagacatCcagaaaagaatgggctgcaa	15	7	12	7	1	0	3	0	0	0	3	2	5	1	4	1	2	2	4	1	2	5	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:4862113C>T	uc003snj.1	-	6	1700	c.1527G>A	c.(1525-1527)TGG>TGA	p.W509*	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Nonsense_Mutation_p.W14*|RADIL_uc011jwc.1_Nonsense_Mutation_p.W269*|RADIL_uc011jwd.1_Intron	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	509	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding	p.W509*(1)		lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		AGTTAGACATCCAGAAAAGAA	0.537													12	42					0	0	0	0	T	4862113	T	T	4862113	4	4	122	1	0	0	0	0	0	1	0	0	13062	856	30	2	1740	2	RADIL	7	4862113	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	614200	4862113	154276550	203	21650											
AHR	196	broad.mit.edu	37	chr7	17379231	17379231	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttaagtaagtctcccttCataccttcagattatcaaca	12	15	3	11	0	5	1	3	0	2	1	6	1	5	1	2	0	2	1	2	0	5	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:17379231C>G	uc011jxz.1	+	10	2395	c.1782C>G	c.(1780-1782)TTC>TTG	p.F594L	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	594					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					AGTCTCCCTTCATACCTTCAG	0.403													51	79					0	0	0	0	G	17379231	G	G	17379231	3	3	122	1	0	0	0	0	1	0	0	0	416	825	29	2	1820	2	AHR	7	17379231	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	12517118	17379231	141759432	204	21651											
DPY19L1	23333	broad.mit.edu	37	chr7	34997615	34997615	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaaataattaccaaagaaGaagcataataagaagttaat	22	8	5	6	0	0	3	0	0	0	3	0	3	0	3	2	0	2	2	2	0	10	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:34997615G>A	uc003tem.3	-	11	1086	c.941C>T	c.(940-942)TCT>TTT	p.S314F		NM_015283	NP_056098	Q2PZI1	D19L1_HUMAN	dpy-19-like 1	314	Helical; (Potential).					integral to membrane					0						TACCAAAGAAGAAGCATAATA	0.289													4	17					0	0	0	0	A	34997615	A	A	34997615	3	1	122	1	0	0	0	0	1	0	0	0	4762	942	33	2	1134	2	DPY19L1	7	34997615	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	17618384	34997615	124141048	205	21652											
NPC1L1	29881	broad.mit.edu	37	chr7	44555448	44555448	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagaccaagccatgcagcagGcccagcagagtgatcaggag	14	3	13	11	0	1	3	1	1	0	2	1	4	1	4	3	2	4	3	3	2	2	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:44555448G>A	uc003tlb.2	-	19	3887	c.3831C>T	c.(3829-3831)GGC>GGT	p.G1277G	NPC1L1_uc003tlc.2_Silent_p.G1250G|NPC1L1_uc011kbw.1_Silent_p.G1204G|NPC1L1_uc003tla.2_Intron	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1277	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	CATGCAGCAGGCCCAGCAGAG	0.577													15	30					0	0	0	0	A	44555448	A	A	44555448	2	1	122	1	0	0	0	0	0	0	0	1	10625	1190	42	4		4	NPC1L1	7	44555448	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	9557833	44555448	114583215	206	21653											
COBL	23242	broad.mit.edu	37	chr7	51096582	51096582	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgtgaggactcaccaagttCcccagctcgtcaatcttaat	10	10	8	13	2	3	1	2	1	1	0	5	2	4	2	3	1	1	2	3	1	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:51096582C>A	uc003tpr.3	-	10	2396	c.2211G>T	c.(2209-2211)GGG>GGT	p.G737G	COBL_uc003tps.2_Silent_p.G794G|COBL_uc011kcl.1_Silent_p.G737G|COBL_uc003tpp.3_Silent_p.G523G|COBL_uc003tpq.3_Silent_p.G678G|COBL_uc003tpo.3_Silent_p.G279G	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	737										skin(3)|ovary(2)	5	Glioma(55;0.08)					TCACCAAGTTCCCCAGCTCGT	0.507													20	41					0.00188189	0.00190307	1	0	A	51096582	A	A	51096582	2	1	122	1	0	0	0	0	0	0	0	1	3668	842	30	2		2	COBL	7	51096582	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6541134	51096582	108042081	207	21654											
VKORC1L1	154807	broad.mit.edu	37	chr7	65419170	65419170	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactttgtgctgaaggagttCtgcatcatctgcatcgtcac	8	14	9	10	1	4	1	2	1	2	0	5	2	4	2	0	1	4	4	0	1	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:65419170C>G	uc003tul.2	+	3	516	c.414C>G	c.(412-414)TTC>TTG	p.F138L	VKORC1L1_uc011kds.1_Missense_Mutation_p.L102V|VKORC1L1_uc003tum.1_5'Flank	NM_173517	NP_775788	Q8N0U8	VKORL_HUMAN	vitamin K epoxide reductase complex, subunit	138	Helical; (Potential).					integral to membrane					0		Lung NSC(55;0.197)			Menadione(DB00170)|Warfarin(DB00682)	TGAAGGAGTTCTGCATCATCT	0.517													35	39					0	0	0	0	G	65419170	G	G	65419170	3	3	122	1	0	0	0	0	1	0	0	0	17241	912	32	2	424	2	VKORC1L1	7	65419170	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	14322588	65419170	93719493	208	21655											
GUSB	2990	broad.mit.edu	37	chr7	65439419	65439419	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatgcagagaaacgttgttGaagaactgcctgcgggccag	11	8	14	8	2	0	4	0	2	0	2	0	5	0	4	2	1	5	3	2	1	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:65439419G>A	uc003tun.2	-	8	1330	c.1254C>T	c.(1252-1254)TTC>TTT	p.F418F	GUSB_uc011kdt.1_Silent_p.F272F	NM_000181	NP_000172	P08236	BGLR_HUMAN	glucuronidase, beta precursor	418					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding				0						AAACGTTGTTGAAGAACTGCC	0.632													35	47					0	0	0	0	A	65439419	A	A	65439419	2	1	122	1	0	0	0	0	0	0	0	1	6941	1281	45	2		2	GUSB	7	65439419	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	20249	65439419	93699244	209	21656											
STYXL1	51657	broad.mit.edu	37	chr7	75630281	75630281	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgcggctgataccttgggtgGaaaagatcagaatgacagag	13	8	14	6	1	1	5	1	2	0	3	1	6	1	6	1	3	2	1	1	3	4	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:75630281G>T	uc003uej.3	-	8	910	c.737C>A	c.(736-738)TCC>TAC	p.S246Y	STYXL1_uc003uef.2_Intron|STYXL1_uc011kgf.1_Intron|STYXL1_uc011kgg.1_Intron|STYXL1_uc003ueh.2_Missense_Mutation_p.S108Y|STYXL1_uc003uek.3_Missense_Mutation_p.S150Y|STYXL1_uc003uel.2_Missense_Mutation_p.S246Y|STYXL1_uc003uem.2_Missense_Mutation_p.S246Y|STYXL1_uc010ldg.1_Intron|STYXL1_uc010ldh.1_Missense_Mutation_p.S246Y|STYXL1_uc003uen.1_Intron	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	246	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						ACCTTGGGTGGAAAAGATCAG	0.567													33	103					1.30998e-17	1.40611e-17	1	0	T	75630281	T	T	75630281	3	4	122	1	0	0	0	0	1	0	0	0	15427	1174	41	2	212	2	STYXL1	7	75630281	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	10190862	75630281	83508382	210	21657											
PEX1	5189	broad.mit.edu	37	chr7	92131290	92131290	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aatctctagccacaaacccgCcagtttctttagctacatgc	11	11	5	14	1	2	0	0	0	2	0	3	0	2	0	3	0	5	2	3	0	5	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:92131290C>G	uc003uly.2	-	14	2426	c.2330G>C	c.(2329-2331)GGC>GCC	p.G777A	PEX1_uc011khr.1_Missense_Mutation_p.G569A|PEX1_uc010ley.2_Missense_Mutation_p.G720A|PEX1_uc011khs.1_Missense_Mutation_p.G455A|PEX1_uc011kht.1_Intron	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	777					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CACAAACCCGCCAGTTTCTTT	0.378													121	191					0	0	0	0	G	92131290	G	G	92131290	3	3	122	1	0	0	0	0	1	0	0	0	11790	739	26	4	1565	4	PEX1	7	92131290	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	16501009	92131290	67007373	211	21658											
SGCE	8910	broad.mit.edu	37	chr7	94230021	94230021	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggaccagtgccactgccGagggcacagccagtgtaatt	12	6	12	11	1	0	0	0	0	0	0	0	2	0	1	4	2	3	2	4	2	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:94230021G>T	uc003unl.2	-	7	1085	c.974C>A	c.(973-975)TCG>TAG	p.S325*	SGCE_uc003unk.2_Nonsense_Mutation_p.S157*|SGCE_uc003unm.2_Nonsense_Mutation_p.S325*|SGCE_uc003unn.2_Nonsense_Mutation_p.S325*|SGCE_uc011kic.1_Nonsense_Mutation_p.S284*|SGCE_uc011kid.1_Nonsense_Mutation_p.S361*	NM_003919	NP_003910	O43556	SGCE_HUMAN	sarcoglycan, epsilon isoform 2	325	Cys-rich.|Helical; (Potential).				cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			TGCCACTGCCGAGGGCACAGC	0.433													19	31					4.35082e-09	4.54595e-09	1	0	T	94230021	T	T	94230021	4	4	122	1	0	0	0	0	0	1	0	0	14267	1059	37	3	511	3	SGCE	7	94230021	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2098731	94230021	64908642	212	21659											
ZNF3	7551	broad.mit.edu	37	chr7	99674971	99674971	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgagatacgagatcagcctGagtttccatggaagggcaag	12	8	13	8	1	1	3	1	2	0	2	2	6	2	4	2	2	2	2	2	2	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:99674971G>C	uc003usq.2	-	3	317	c.10C>G	c.(10-12)CAG>GAG	p.Q4E	ZNF3_uc003usp.2_Missense_Mutation_p.Q4E|ZNF3_uc003usr.2_Missense_Mutation_p.Q4E|ZNF3_uc010lgj.2_Intron|ZNF3_uc003uss.2_Intron|ZNF3_uc003ust.3_Missense_Mutation_p.Q4E	NM_032924	NP_116313	P17036	ZNF3_HUMAN	zinc finger protein 3 isoform 2	4					cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			AGATCAGCCTGAGTTTCCATG	0.438													50	88					0	0	0	0	C	99674971	C	C	99674971	3	2	122	1	0	0	0	0	1	0	0	0	17896	1299	45	2	1475	2	ZNF3	7	99674971	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5444950	99674971	59463692	213	21660											
C7orf43	55262	broad.mit.edu	37	chr7	99754719	99754719	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccctcccaggacctcaccaGacattgtccaccagcagcac	10	5	6	20	0	1	1	1	0	0	1	3	2	3	2	7	1	2	2	7	1	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:99754719G>A	uc003utr.2	-	5	1023	c.843C>T	c.(841-843)GTC>GTT	p.V281V	C7orf43_uc010lgo.2_5'Flank|C7orf43_uc010lgp.2_5'UTR|C7orf43_uc011kjj.1_Silent_p.V49V|C7orf43_uc003uts.2_Silent_p.V12V	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	281											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GACCTCACCAGACATTGTCCA	0.572													21	66					0	0	0	0	A	99754719	A	A	99754719	2	1	122	1	0	0	0	0	0	0	0	1	2404	929	33	2		2	C7orf43	7	99754719	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	79748	99754719	59383944	214	21661											
C7orf43	55262	broad.mit.edu	37	chr7	99755503	99755503	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggggcagtctatccagtGaaacggtgagtgggaagatg	10	8	17	6	1	1	3	0	2	1	1	2	4	2	4	1	4	1	1	1	4	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:99755503G>A	uc003utr.2	-	2	650	c.470C>T	c.(469-471)TCA>TTA	p.S157L	C7orf43_uc010lgo.2_5'Flank|C7orf43_uc010lgp.2_5'Flank|C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003uts.2_5'UTR	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	157											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCTATCCAGTGAAACGGTGAG	0.537													11	29					0	0	0	0	A	99755503	A	A	99755503	3	1	122	1	0	0	0	0	1	0	0	0	2404	1294	45	2	1312	2	C7orf43	7	99755503	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	784	99755503	59383160	215	21662											
ACTL6B	51412	broad.mit.edu	37	chr7	100246206	100246211	+	In_Frame_Del	DEL	GATGTC	-	-																															gcgatcatgtaaggtgggatGatgtcaatggccatctcctg																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:100246206_100246211delGATGTC	uc003uvy.2	-	7	744_749	c.637_642delGACATC	c.(637-642)GACATCdel	p.DI213del	ACTL6B_uc003uvx.1_In_Frame_Del_p.DI4del|ACTL6B_uc003uvz.2_RNA	NM_016188	NP_057272	O94805	ACL6B_HUMAN	actin-like 6B	213_214					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			ovary(1)	1	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					AAGGTGGGATGATGTCAATGGCCATC	0.597													---	---	---								-	100246211	-	-	100246206	7	5	122	1	0	1	0	1	0	0	0	0	199	1280	45	0	670	0	ACTL6B	7	100246206	In_Frame_Del	DEL	GATGTC	TCGA-CR-6472-01A-11D-1870-08	490703	100246206	58892457	216	21663											
ACHE	43	broad.mit.edu	37	chr7	100488803	100488803	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcataccggtggcgctgagCaatttggggaggaagcggtt	8	9	17	7	3	0	1	0	1	0	0	0	3	0	3	1	6	4	4	1	6	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:100488803C>T	uc003uxd.2	-	3	1866	c.1710G>A	c.(1708-1710)TTG>TTA	p.L570L	UFSP1_uc003uxc.3_5'Flank|ACHE_uc003uxe.2_Silent_p.L570L|ACHE_uc003uxf.2_Silent_p.L570L|ACHE_uc003uxg.2_Silent_p.L570L|ACHE_uc003uxh.2_Silent_p.L482L|ACHE_uc003uxi.2_Silent_p.L570L	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	570					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	TGGCGCTGAGCAATTTGGGGA	0.701													8	9					0	0	0	0	T	100488803	T	T	100488803	2	4	122	1	0	0	0	0	0	0	0	1	141	709	25	4		4	ACHE	7	100488803	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	242597	100488803	58649860	217	21664											
PRKRIP1	79706	broad.mit.edu	37	chr7	102045060	102045060	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcagcaaaaattggatgcaGagtttcagaaaagactggaa	17	8	11	5	0	1	3	1	0	0	3	1	5	1	5	0	2	3	4	0	2	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:102045060G>C	uc003uzh.2	+	4	377	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	PRKRIP1_uc003uzf.2_Missense_Mutation_p.E57Q|PRKRIP1_uc003uzg.2_Missense_Mutation_p.E57Q|PRKRIP1_uc011kkq.1_Missense_Mutation_p.E51Q|PRKRIP1_uc011kkr.1_Missense_Mutation_p.E108Q	NM_024653	NP_078929	Q9H875	PKRI1_HUMAN	PRKR interacting protein 1 (IL11 inducible)	108	Potential.|Required for RNA-binding (By similarity).					nucleolus				ovary(1)	1						ATTGGATGCAGAGTTTCAGAA	0.483											OREG0018229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	102					0	0	0	0	C	102045060	C	C	102045060	3	2	122	1	0	0	0	0	1	0	0	0	12587	943	33	2	336	2	PRKRIP1	7	102045060	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1556257	102045060	57093603	218	21665											
MLL5	55904	broad.mit.edu	37	chr7	104703989	104704002	+	Frame_Shift_Del	DEL	ACATGATGATGGAT	-	-																															aggtgcatatgtggttttacAcatgatgatggatacatgat																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:104703989_104704002delACATGATGATGGAT	uc003vcm.2	+	5	912_925	c.378_391delACATGATGATGGAT	c.(376-393)ACACATGATGATGGATACfs	p.T126fs	MLL5_uc010lja.1_5'UTR|MLL5_uc010ljb.1_Frame_Shift_Del_p.T126fs|MLL5_uc003vcl.2_Frame_Shift_Del_p.T126fs|MLL5_uc010ljc.2_Frame_Shift_Del_p.T126fs	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	126_131	PHD-type.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						GTGGTTTTACACATGATGATGGATACATGATCTG	0.346													---	---	---								-	104704002	-	-	104703989	7	5	122	1	0	1	0	1	0	0	0	0	9677	146	6	0	388	0	MLL5	7	104703989	Frame_Shift_Del	DEL	ACATGATGATGGAT	TCGA-CR-6472-01A-11D-1870-08	2658929	104703989	54434674	219	21666											
LAMB4	22798	broad.mit.edu	37	chr7	107678026	107678026	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaccttctcgatgtcttctgGaggcacgttttcctcttaaa	8	15	7	11	2	4	0	0	0	4	0	6	2	5	1	2	2	1	2	2	2	3	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:107678026G>C	uc010ljo.1	-	30	4570	c.4486C>G	c.(4486-4488)CCA>GCA	p.P1496A	LAMB4_uc003vey.2_Missense_Mutation_p.P1496A|LAMB4_uc010ljp.1_Missense_Mutation_p.P465A	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1496	Domain I.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						ATGTCTTCTGGAGGCACGTTT	0.388													31	71					0	0	0	0	C	107678026	C	C	107678026	3	2	122	1	0	0	0	0	1	0	0	0	8653	1174	41	2	819	2	LAMB4	7	107678026	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2974037	107678026	51460637	220	21667											
WNT2	7472	broad.mit.edu	37	chr7	116918349	116918349	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccgggtgacatgggaggTgtcgtagcctctcccacagc	7	8	13	13	2	1	1	0	1	1	0	4	2	2	2	3	3	2	1	3	3	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:116918349T>G	uc003viz.2	-	5	1243	c.943A>C	c.(943-945)ACC>CCC	p.T315P	WNT2_uc003vja.2_Missense_Mutation_p.T219P	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	315					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		ACATGGGAGGTGTCGTAGCCT	0.597													10	34					0	0	0	0	G	116918349	G	G	116918349	3	3	122	1	0	0	0	0	1	0	0	0	17454	1696	59	5	143	5	WNT2	7	116918349	Missense_Mutation	SNP	T	TCGA-CR-6472-01A-11D-1870-08	9240323	116918349	42220314	221	21668											
FSCN3	29999	broad.mit.edu	37	chr7	127240257	127240257	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccttctccagcacagggggGatccttctggtcaataacat	9	11	9	12	0	3	0	1	0	2	0	6	1	5	1	3	4	2	1	3	4	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:127240257G>A	uc003vmd.1	+	6	1520	c.1301G>A	c.(1300-1302)GGA>GAA	p.G434E	FSCN3_uc011koh.1_Silent_p.G298G|FSCN3_uc010llc.1_Silent_p.G432G	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	434						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						GCACAGGGGGGATCCTTCTGG	0.562													21	41					0	0	0	0	A	127240257	A	A	127240257	3	1	122	1	0	0	0	0	1	0	0	0	6103	1174	41	2	1323	2	FSCN3	7	127240257	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	10321908	127240257	31898406	222	21669											
NUP205	23165	broad.mit.edu	37	chr7	135292103	135292103	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgagaatctcctcagctggCtgagctatgttaccaggtac	9	10	11	11	1	2	2	1	1	1	1	3	3	2	2	2	2	4	5	2	2	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:135292103C>G	uc003vsw.2	+	22	3210	c.3179C>G	c.(3178-3180)GCT>GGT	p.A1060G		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1060					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						CCTCAGCTGGCTGAGCTATGT	0.498													24	19					0	0	0	0	G	135292103	G	G	135292103	3	3	122	1	0	0	0	0	1	0	0	0	10813	797	28	4	3265	4	NUP205	7	135292103	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	8051846	135292103	23846560	223	21670											
EPHB6	2051	broad.mit.edu	37	chr7	142561964	142561964	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctttactaccgtcaggctGaggagcccgacagccctgac	8	7	10	16	2	1	2	1	2	0	0	1	4	1	3	4	2	4	1	4	2	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:142561964G>A	uc011kst.1	+	7	1193	c.406G>A	c.(406-408)GAG>AAG	p.E136K	EPHB6_uc011ksu.1_Missense_Mutation_p.E136K|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_5'UTR	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	136	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CCGTCAGGCTGAGGAGCCCGA	0.577													31	50					0	0	0	0	A	142561964	A	A	142561964	3	1	122	1	0	0	0	0	1	0	0	0	5202	1291	45	2	416	2	EPHB6	7	142561964	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	7269861	142561964	16576699	224	21671											
EPHA1	2041	broad.mit.edu	37	chr7	143104760	143104760	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccctgtgccttgcttgtgtCcatcagagtaactgaaagtg	8	13	10	10	0	1	2	1	1	0	1	3	2	3	2	3	0	3	2	3	0	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:143104760C>T	uc003wcz.2	-	2	181	c.94G>A	c.(94-96)GAC>AAC	p.D32N	uc003wda.2_5'Flank	NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	32	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TTGCTTGTGTCCATCAGAGTA	0.562													99	149					0	0	0	0	T	143104760	T	T	143104760	3	4	122	1	0	0	0	0	1	0	0	0	5189	855	30	2	2904	2	EPHA1	7	143104760	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	542796	143104760	16033903	225	21672											
OR2A2	442361	broad.mit.edu	37	chr7	143807003	143807003	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttggcttttgctgttacaGagtgcctgattttggtggtg	5	18	13	5	0	0	2	0	1	0	1	0	2	0	2	1	3	3	3	1	3	1	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr7:143807003G>C	uc011ktz.1	+	1	328	c.328G>C	c.(328-330)GAG>CAG	p.E110Q		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					TGCTGTTACAGAGTGCCTGAT	0.443													57	126					0	0	0	0	C	143807003	C	C	143807003	3	2	122	1	0	0	0	0	1	0	0	0	11031	943	33	2	330	2	OR2A2	7	143807003	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	702243	143807003	15331660	226	21673											
MSRA	4482	broad.mit.edu	37	chr8	10102704	10102704	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttgcaggaggctatacttCaaatcctacttataaagaag	14	13	7	7	0	1	1	1	0	0	1	2	2	2	2	1	2	3	2	1	2	8	8			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:10102704C>T	uc003wsx.2	+	3	499	c.302C>T	c.(301-303)TCA>TTA	p.S101L	MSRA_uc011kwx.1_Intron|MSRA_uc011kwy.1_Missense_Mutation_p.S58L|MSRA_uc003wsz.2_Missense_Mutation_p.S58L|MSRA_uc003wsy.2_Missense_Mutation_p.S35L	NM_012331	NP_036463	Q9UJ68	MSRA_HUMAN	methionine sulfoxide reductase A isoform a	101					methionine metabolic process|protein modification process|response to oxidative stress	mitochondrion|nucleus	peptide-methionine-(S)-S-oxide reductase activity				0		Myeloproliferative disorder(644;0.178)			L-Methionine(DB00134)	GGCTATACTTCAAATCCTACT	0.408													34	60					0	0	0	0	T	10102704	T	T	10102704	3	4	122	1	0	0	0	0	1	0	0	0	9940	838	29	2	329	2	MSRA	8	10102704	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08		10102704	136261318	227	21674											
CTSB	1508	broad.mit.edu	37	chr8	11706668	11706668	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagatggcttccacagccccGaaggcctgcaggaacgagcc	10	4	13	14	2	0	1	0	0	0	1	1	5	1	2	5	3	4	2	5	3	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:11706668G>A	uc003wum.2	-	7	657	c.333C>T	c.(331-333)TTC>TTT	p.F111F	CTSB_uc003wul.2_5'Flank|CTSB_uc011kxl.1_Silent_p.F32F|CTSB_uc003wun.2_Silent_p.F111F|CTSB_uc003wuo.2_Silent_p.F111F|CTSB_uc003wup.2_Silent_p.F111F|CTSB_uc003wuq.2_Silent_p.F111F|CTSB_uc010lsc.2_Intron|CTSB_uc003wur.2_Silent_p.F111F|CTSB_uc003wus.1_Silent_p.F111F|CTSB_uc003wut.1_Silent_p.F111F|CTSB_uc003wuu.2_5'UTR	NM_147780	NP_680090	P07858	CATB_HUMAN	cathepsin B preproprotein	111					proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity				0	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)		CCACAGCCCCGAAGGCCTGCA	0.657													7	27					0	0	0	0	A	11706668	A	A	11706668	2	1	122	1	0	0	0	0	0	0	0	1	4047	1049	37	1		1	CTSB	8	11706668	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1603964	11706668	134657354	228	21675											
EPHX2	2053	broad.mit.edu	37	chr8	27394310	27394310	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattgttttagggagtggctGaggctgaactggaacagaac	11	10	15	5	0	0	3	0	2	0	1	0	6	0	5	0	4	3	3	0	4	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:27394310G>A	uc003xfu.2	+	13	1261	c.1180G>A	c.(1180-1182)GAG>AAG	p.E394K	EPHX2_uc010lut.1_Missense_Mutation_p.E394K|EPHX2_uc010luu.2_Missense_Mutation_p.E362K|EPHX2_uc010luv.2_Missense_Mutation_p.E328K|EPHX2_uc003xfv.2_Missense_Mutation_p.E341K|EPHX2_uc010luw.2_Missense_Mutation_p.E328K	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	394	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	GGGAGTGGCTGAGGCTGAACT	0.512													30	68					0	0	0	0	A	27394310	A	A	27394310	3	1	122	1	0	0	0	0	1	0	0	0	5204	1291	45	2	1230	2	EPHX2	8	27394310	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	15687642	27394310	118969712	229	21676											
C8orf80	389643	broad.mit.edu	37	chr8	27898624	27898624	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctggcggtcctgaccccttCttgcagaggctgctccatgc	4	10	11	16	1	1	2	0	1	1	1	3	2	3	2	5	3	3	3	5	3	0	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:27898624C>T	uc003xgm.3	-	13	1698	c.1555G>A	c.(1555-1557)GAA>AAA	p.E519K		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	519						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		CTGACCCCTTCTTGCAGAGGC	0.567													9	5					0	0	0	0	T	27898624	T	T	27898624	3	4	122	1	0	0	0	0	1	0	0	0	2451	922	32	2	863	2	C8orf80	8	27898624	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	504314	27898624	118465398	230	21677											
ELP3	55140	broad.mit.edu	37	chr8	27967950	27967950	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacagacaagacaccgaataGaacaggtacatttttaaaaa	20	8	6	7	1	0	3	0	0	0	3	0	4	0	3	1	1	3	1	1	1	9	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:27967950G>C	uc003xgo.3	+	6	605	c.457G>C	c.(457-459)GAA>CAA	p.E153Q	ELP3_uc003xgn.3_Missense_Mutation_p.E138Q|ELP3_uc011laq.1_Missense_Mutation_p.E81Q|ELP3_uc011lar.1_Missense_Mutation_p.E61Q|ELP3_uc011las.1_Missense_Mutation_p.E34Q|ELP3_uc011lat.1_Missense_Mutation_p.E34Q	NM_018091	NP_060561	Q9H9T3	ELP3_HUMAN	elongation protein 3 homolog	153					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding				0		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		ACACCGAATAGAACAGGTACA	0.343													31	59					0	0	0	0	C	27967950	C	C	27967950	3	2	122	1	0	0	0	0	1	0	0	0	5105	943	33	2	479	2	ELP3	8	27967950	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	69326	27967950	118396072	231	21678											
C8orf4	56892	broad.mit.edu	37	chr8	40011187	40011187	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttgaaaacacagaccaaGaatcactagaaaggctcttc	16	9	6	10	0	3	4	1	1	2	3	4	4	3	4	1	1	1	1	1	1	6	3	rs10353		TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:40011187G>A	uc003xnq.1	+	1	199	c.136G>A	c.(136-138)GAA>AAA	p.E46K		NM_020130	NP_064515	Q9NR00	CH004_HUMAN	thyroid cancer-1	46					apoptosis					ovary(1)	1	Ovarian(28;0.0173)	all_cancers(7;5.34e-21)|all_epithelial(6;1.04e-14)|Lung NSC(58;9.35e-06)|all_lung(54;1.39e-05)|Hepatocellular(245;0.00745)|Breast(189;0.0334)|Colorectal(162;0.0815)|Myeloproliferative disorder(644;0.116)|Esophageal squamous(32;0.141)	LUSC - Lung squamous cell carcinoma(45;0.000149)	KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		CACAGACCAAGAATCACTAGA	0.488													29	46					0	0	0	0	A	40011187	A	A	40011187	3	1	122	1	0	0	0	0	1	0	0	0	2437	943	33	2	138	2	C8orf4	8	40011187	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	12043237	40011187	106352835	232	21679											
MCM4	4173	broad.mit.edu	37	chr8	48885504	48885504	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtcgcactgtactaccaGagcgaggagcaggcagagga	11	5	15	10	2	0	2	0	0	0	2	1	5	0	4	1	4	4	4	1	4	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:48885504G>C	uc003xqk.1	+	14	2111	c.2016G>C	c.(2014-2016)CAG>CAC	p.Q672H	MCM4_uc003xql.1_Missense_Mutation_p.Q672H|MCM4_uc011ldi.1_Missense_Mutation_p.Q659H	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	672					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				TGTACTACCAGAGCGAGGAGC	0.552													14	28					0	0	0	0	C	48885504	C	C	48885504	3	2	122	1	0	0	0	0	1	0	0	0	9442	933	33	2	2066	2	MCM4	8	48885504	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8874317	48885504	97478518	233	21680											
HEY1	23462	broad.mit.edu	37	chr8	80677568	80677568	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggccgacagggaggccactGaggagagcagaggcggcgac	11	1	19	10	3	0	3	0	1	0	2	0	7	0	4	2	6	1	1	2	6	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:80677568G>A	uc003ybm.2	-	5	970	c.770C>T	c.(769-771)TCA>TTA	p.S257L	HEY1_uc010lzq.2_Missense_Mutation_p.S138L|HEY1_uc003ybl.2_Missense_Mutation_p.S261L	NM_012258	NP_036390	Q9Y5J3	HEY1_HUMAN	hairy/enhancer-of-split related with YRPW motif	257					angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding			lung(3)	3	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			GGAGGCCACTGAGGAGAGCAG	0.652											OREG0018837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	6					0	0	0	0	A	80677568	A	A	80677568	3	1	122	1	0	0	0	0	1	0	0	0	7117	1294	45	2	148	2	HEY1	8	80677568	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	31792064	80677568	65686454	234	21681											
ESRP1	54845	broad.mit.edu	37	chr8	95709092	95709092	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cattttagtatgcaaccgagGatggacttatacacacaaat	15	11	7	8	1	0	0	0	0	0	0	0	3	0	2	1	2	3	2	1	2	6	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:95709092G>C	uc003ygq.3	+	15	2167	c.1984G>C	c.(1984-1986)GAT>CAT	p.D662H	ESRP1_uc003ygr.3_Missense_Mutation_p.D658H|ESRP1_uc003ygs.3_Intron|ESRP1_uc003ygt.3_Intron|ESRP1_uc003ygu.3_Intron|ESRP1_uc003ygv.2_Intron|ESRP1_uc003ygw.2_Missense_Mutation_p.R451S	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	662					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						TGCAACCGAGGATGGACTTAT	0.388													3	10					0	0	0	0	C	95709092	C	C	95709092	3	2	122	1	0	0	0	0	1	0	0	0	5282	1174	41	2	2042	2	ESRP1	8	95709092	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	15031524	95709092	50654930	235	21682											
INTS8	55656	broad.mit.edu	37	chr8	95869113	95869113	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatgttgcttttggatattCatacacacgaagctgggaca	12	12	10	7	1	1	1	1	0	0	1	1	4	1	3	0	2	3	3	0	2	3	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:95869113C>T	uc003yhb.2	+	15	1987	c.1861C>T	c.(1861-1863)CAT>TAT	p.H621Y	INTS8_uc003yha.1_Missense_Mutation_p.H621Y|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.H448Y	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	621					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TTTGGATATTCATACACACGA	0.488													51	77					0	0	0	0	T	95869113	T	T	95869113	3	4	122	1	0	0	0	0	1	0	0	0	7823	826	29	2	1919	2	INTS8	8	95869113	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	160021	95869113	50494909	236	21683											
TTC35	9694	broad.mit.edu	37	chr8	109462710	109462710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactagactatggtcgggatGacttggcattggtaggtatt	9	13	13	6	1	0	2	0	1	0	1	1	3	0	3	0	5	0	3	0	5	4	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:109462710G>A	uc003ymw.1	+	3	243	c.208G>A	c.(208-210)GAC>AAC	p.D70N		NM_014673	NP_055488	Q15006	TTC35_HUMAN	tetratricopeptide repeat domain 35	70						endoplasmic reticulum|nucleus	binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.34e-10)			TGGTCGGGATGACTTGGCATT	0.318													34	63					0	0	0	0	A	109462710	A	A	109462710	3	1	122	1	0	0	0	0	1	0	0	0	16771	1290	45	2	218	2	TTC35	8	109462710	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	13593597	109462710	36901312	237	21684											
DERL1	79139	broad.mit.edu	37	chr8	124042888	124042888	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatataagaaatataaattGaccaaataaagaaatccagt	22	10	5	4	0	0	4	0	2	0	2	1	4	1	4	2	0	0	0	2	0	10	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:124042888G>C	uc003ypl.2	-	2	508	c.222C>G	c.(220-222)GTC>GTG	p.V74V	DERL1_uc003ypm.2_Silent_p.V74V|DERL1_uc011lif.1_Intron|DERL1_uc003ypn.2_Silent_p.V74V	NM_024295	NP_077271	Q9BUN8	DERL1_HUMAN	Der1-like domain family, member 1 isoform a	74	Helical; Name=2; (Potential).				endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|intracellular transport of viral proteins in host cell|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	MHC class I protein binding|receptor activity				0	Lung NSC(37;1.06e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			AATATAAATTGACCAAATAAA	0.363													32	71					0	0	0	0	C	124042888	C	C	124042888	2	2	122	1	0	0	0	0	0	0	0	1	4468	1277	45	2		2	DERL1	8	124042888	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	14580178	124042888	22321134	238	21685											
FER1L6	654463	broad.mit.edu	37	chr8	125078776	125078776	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctaagtattatgcctccctGaagaaagcccagaaggtaga	14	9	9	9	0	1	4	0	1	1	3	2	4	2	4	3	1	2	2	3	1	7	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:125078776G>A	uc003yqw.2	+	27	3869	c.3663G>A	c.(3661-3663)CTG>CTA	p.L1221L	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1221	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ATGCCTCCCTGAAGAAAGCCC	0.483													9	158					0	0	0	0	A	125078776	A	A	125078776	2	1	122	1	0	0	0	0	0	0	0	1	5847	1277	45	2		2	FER1L6	8	125078776	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1035888	125078776	21285246	239	21686											
PHF20L1	51105	broad.mit.edu	37	chr8	133855066	133855066	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagaacaagaattccacatGagaagtaaaaacagtttaca	21	7	7	6	0	0	3	0	1	0	3	1	5	1	3	1	0	3	2	1	0	9	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:133855066G>A	uc003ytt.2	+	19	3019	c.2694G>A	c.(2692-2694)ATG>ATA	p.M898I	PHF20L1_uc011lja.1_Missense_Mutation_p.M872I	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	898							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			AATTCCACATGAGAAGTAAAA	0.383													34	78					0	0	0	0	A	133855066	A	A	133855066	3	1	122	1	0	0	0	0	1	0	0	0	11887	1290	45	2	2860	2	PHF20L1	8	133855066	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8776290	133855066	12508956	240	21687											
PSCA	8000	broad.mit.edu	37	chr8	143763453	143763453	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgctgtgacaccgacttgtGcaacgccagcggggcccatg	7	7	14	13	3	0	1	0	1	0	0	0	2	0	1	3	2	4	2	3	2	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:143763453G>A	uc003ywu.2	+	3	330	c.275G>A	c.(274-276)TGC>TAC	p.C92Y	uc003ywt.1_5'Flank	NM_005672	NP_005663	O43653	PSCA_HUMAN	prostate stem cell antigen preproprotein	83											0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ACCGACTTGTGCAACGCCAGC	0.627													14	23					0	0	0	0	A	143763453	A	A	143763453	3	1	122	1	0	0	0	0	1	0	0	0	12707	1319	46	4	258	4	PSCA	8	143763453	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	9908387	143763453	2600569	241	21688											
ZNF707	286075	broad.mit.edu	37	chr8	144776267	144776267	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccagaagaaccacacgcGcgagaagcccttctgctgcg	11	4	10	16	4	1	3	0	0	1	3	1	4	1	3	4	0	4	1	4	0	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:144776267G>A	uc003yze.3	+	7	998	c.683G>A	c.(682-684)CGC>CAC	p.R228H	ZNF707_uc010mfh.2_Missense_Mutation_p.R228H|ZNF707_uc010mfi.2_Missense_Mutation_p.R228H|ZNF707_uc003yzf.3_Missense_Mutation_p.R228H|ZNF707_uc003yzh.3_Missense_Mutation_p.R155H|ZNF707_uc011lkq.1_RNA	NM_173831	NP_776192	Q96C28	ZN707_HUMAN	zinc finger protein 707	228					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;5.6e-41)|Epithelial(56;1.02e-39)|all cancers(56;9.65e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AACCACACGCGCGAGAAGCCC	0.667													11	14					0	0	0	0	A	144776267	A	A	144776267	3	1	122	1	0	0	0	0	1	0	0	0	18178	1087	38	1	697	1	ZNF707	8	144776267	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1012814	144776267	1587755	242	21689											
SCRIB	23513	broad.mit.edu	37	chr8	144877604	144877604	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgaccttgcctgggccctCagggctcagctcccggtcga	4	9	12	16	2	3	1	2	1	1	0	5	2	4	1	4	3	2	2	4	3	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:144877604C>G	uc003yzp.1	-	25	3707	c.3700G>C	c.(3700-3702)GAG>CAG	p.E1234Q	SCRIB_uc003yzn.1_5'UTR|SCRIB_uc003yzo.1_Missense_Mutation_p.E1234Q	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	1234					activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CCTGGGCCCTCAGGGCTCAGC	0.677													4	10					0	0	0	0	G	144877604	G	G	144877604	3	3	122	1	0	0	0	0	1	0	0	0	14002	835	29	2	1319	2	SCRIB	8	144877604	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	101337	144877604	1486418	243	21690											
COMMD5	28991	broad.mit.edu	37	chr8	146076069	146076069	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagtcctgcagtctgcgctCacacctcttctccagatctg	6	12	7	16	1	6	1	2	0	4	1	8	1	7	1	3	0	2	2	3	0	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr8:146076069C>G	uc003zem.2	-	2	786	c.655G>C	c.(655-657)GAG>CAG	p.E219Q	COMMD5_uc003zel.1_RNA|COMMD5_uc003zen.2_Missense_Mutation_p.E219Q|COMMD5_uc003zeo.3_Missense_Mutation_p.E219Q|COMMD5_uc010mgf.2_Missense_Mutation_p.E219Q	NM_001081004	NP_001074473	Q9GZQ3	COMD5_HUMAN	COMM domain containing 5	219						nucleus	protein binding			ovary(1)	1	all_cancers(97;1.14e-11)|all_epithelial(106;7.74e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)			AGTCTGCGCTCACACCTCTTC	0.582													10	20					0	0	0	0	G	146076069	G	G	146076069	3	3	122	1	0	0	0	0	1	0	0	0	3734	835	29	2	23	2	COMMD5	8	146076069	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1198465	146076069	287953	244	21691											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18777191	18777191	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcggggaggaagggcggcccGaaggaggccctgcagaccca	9	1	19	12	3	0	1	0	0	0	1	0	5	0	4	3	7	1	1	3	7	2	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr9:18777191G>A	uc003zne.3	+	19	3091	c.2964G>A	c.(2962-2964)CCG>CCA	p.P988P		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	988						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		AGGGCGGCCCGAAGGAGGCCC	0.652													12	16					0	0	0	0	A	18777191	A	A	18777191	2	1	122	1	0	0	0	0	0	0	0	1	274	1045	37	1		1	ADAMTSL1	9	18777191	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08		18777191	122436240	245	21692											
TOPORS	10210	broad.mit.edu	37	chr9	32541770	32541770	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtatcctcctttacttcaGaatccttatcactgtcactg	8	16	4	13	0	3	1	3	0	0	1	6	1	6	1	3	0	1	1	3	0	4	5	rs142671355		TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr9:32541770G>A	uc003zrb.2	-	3	2920	c.2753C>T	c.(2752-2754)TCT>TTT	p.S918F	TOPORS_uc003zrc.2_Missense_Mutation_p.S851F	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	918					DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CTTTACTTCAGAATCCTTATC	0.338													65	44					0	0	0	0	A	32541770	A	A	32541770	3	1	122	1	0	0	0	0	1	0	0	0	16437	942	33	2	388	2	TOPORS	9	32541770	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	13764579	32541770	108671661	246	21693											
TAF1L	138474	broad.mit.edu	37	chr9	32630255	32630255	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcgtcactcccagcatCttcctcatcatcttctcctt	5	17	2	17	1	7	0	3	0	4	0	11	0	9	0	3	0	1	1	3	0	0	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr9:32630255C>A	uc003zrg.1	-	1	5413	c.5323G>T	c.(5323-5325)GAT>TAT	p.D1775Y		NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1775					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CTCCCAGCATCTTCCTCATCA	0.453													48	47					2.14674e-31	2.36894e-31	1	0	A	32630255	A	A	32630255	3	1	122	1	0	0	0	0	1	0	0	0	15589	913	32	2	161	2	TAF1L	9	32630255	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	88485	32630255	108583176	247	21694											
CCDC107	203260	broad.mit.edu	37	chr9	35660595	35660595	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaacagctggcccagacaGagcagcacctgaacaacctg	14	3	9	15	0	0	3	0	1	0	2	0	3	0	3	3	1	6	3	3	1	3	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr9:35660595G>C	uc011lox.1	+	4	427	c.361G>C	c.(361-363)GAG>CAG	p.E121Q	RMRP_uc003zxh.1_5'Flank|CCDC107_uc011loy.1_Missense_Mutation_p.E121Q|CCDC107_uc003zxj.2_Missense_Mutation_p.E121Q|CCDC107_uc003zxk.2_3'UTR|C9orf100_uc003zxl.2_RNA|C9orf100_uc003zxm.1_3'UTR	NM_174923	NP_777583	Q8WV48	CC107_HUMAN	coiled-coil domain containing 107 precursor	121	Potential.					integral to membrane					0	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GGCCCAGACAGAGCAGCACCT	0.527													23	44					0	0	0	0	C	35660595	C	C	35660595	3	2	122	1	0	0	0	0	1	0	0	0	2754	943	33	2	375	2	CCDC107	9	35660595	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3030340	35660595	105552836	248	21695											
GLIPR2	152007	broad.mit.edu	37	chr9	36162499	36162499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcttcttcgaagaaaacGtcctgccgccgaagaagtaa	13	7	11	10	4	1	2	0	0	1	2	3	4	2	2	3	1	2	2	3	1	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr9:36162499G>A	uc003zyz.2	+	5	479	c.445G>A	c.(445-447)GTC>ATC	p.V149I	GLIPR2_uc010mlf.1_3'UTR|GLIPR2_uc003zza.2_RNA|GLIPR2_uc003zyy.1_Intron	NM_022343	NP_071738	Q9H4G4	GAPR1_HUMAN	GLI pathogenesis-related 2	149				TGHFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNVVN EGFFEENVLPPKK -> IRFFFFNFLLFLSKPLLYFSYF (in Ref. 3; BAC11019).		extracellular region|Golgi membrane				skin(3)|central_nervous_system(1)	4						CGAAGAAAACGTCCTGCCGCC	0.537													29	22					0	0	0	0	A	36162499	A	A	36162499	3	1	122	1	0	0	0	0	1	0	0	0	6481	1145	40	1	463	1	GLIPR2	9	36162499	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	501904	36162499	105050932	249	21696											
ZNF658	26149	broad.mit.edu	37	chr9	40772752	40772752	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaattctctgatgtgcacaGaggtgtgttctttgggagaa	9	14	13	5	0	2	4	0	2	2	2	3	5	2	4	0	2	1	2	0	2	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr9:40772752G>C	uc004abs.2	-	5	2675	c.2523C>G	c.(2521-2523)CTC>CTG	p.L841L	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Silent_p.L841L	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	841	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GATGTGCACAGAGGTGTGTTC	0.433													15	66					0	0	0	0	C	40772752	C	C	40772752	2	2	122	1	0	0	0	0	0	0	0	1	18136	929	33	2		2	ZNF658	9	40772752	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4610253	40772752	100440679	250	21697											
ZNF169	169841	broad.mit.edu	37	chr9	97062208	97062208	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacagatcttcccaagctCatctgcaggaggtgacttcc	10	9	8	14	0	3	2	1	1	2	1	5	3	5	3	2	2	2	2	2	2	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr9:97062208C>A	uc004aum.1	+	5	473	c.368C>A	c.(367-369)TCA>TAA	p.S123*		NM_194320	NP_919301	Q14929	ZN169_HUMAN	zinc finger protein 169	123						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				TTCCCAAGCTCATCTGCAGGA	0.507													27	22					1.12875e-08	1.17159e-08	1	0	A	97062208	A	A	97062208	4	1	122	1	0	0	0	0	0	1	0	0	17809	838	29	2	382	2	ZNF169	9	97062208	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	56289456	97062208	44151223	251	21698											
ZNF462	58499	broad.mit.edu	37	chr9	109687761	109687761	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtggtgtcttatgagagctCaagcatcaatggtagaaagt	12	12	12	5	0	3	2	2	1	1	2	3	3	3	2	0	2	2	3	0	2	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr9:109687761C>G	uc004bcz.2	+	3	1857	c.1568C>G	c.(1567-1569)TCA>TGA	p.S523*	ZNF462_uc010mto.2_Nonsense_Mutation_p.S371*|ZNF462_uc004bda.2_Nonsense_Mutation_p.S371*	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	523					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						TATGAGAGCTCAAGCATCAAT	0.373													18	17					0	0	0	0	G	109687761	G	G	109687761	4	3	122	1	0	0	0	0	0	1	0	0	17993	838	29	2	1574	2	ZNF462	9	109687761	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	12625553	109687761	31525670	252	21699											
C5	727	broad.mit.edu	37	chr9	123808549	123808549	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtaactaaattttttatcagGataacttttaatagagattg	15	17	6	3	0	1	1	1	0	0	1	1	3	1	2	0	1	2	1	0	1	7	10			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr9:123808549G>C	uc004bkv.2	-	2	208	c.178C>G	c.(178-180)CCT>GCT	p.P60A	C5_uc010mvm.1_Missense_Mutation_p.P60A|C5_uc010mvn.1_Missense_Mutation_p.P60A	NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	60					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TTTTTATCAGGATAACTTTTA	0.313													30	21					0	0	0	0	C	123808549	C	C	123808549	3	2	122	1	0	0	0	0	1	0	0	0	2290	1174	41	2	5012	2	C5	9	123808549	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	14120788	123808549	17404882	253	21700											
DPP7	29952	broad.mit.edu	37	chr9	140007428	140007428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gacggggttggcagggagggGacccaggaagtcagtggggt	8	5	22	6	1	1	0	1	0	0	0	1	4	1	3	1	9	0	2	1	9	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr9:140007428G>A	uc004clh.2	-	7	877	c.847C>T	c.(847-849)CCC>TCC	p.P283S		NM_013379	NP_037511	Q9UHL4	DPP2_HUMAN	dipeptidyl peptidase 7 preproprotein	283						cytoplasmic membrane-bounded vesicle|extracellular region|lysosome	aminopeptidase activity|protein binding|serine-type peptidase activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;4.25e-05)|Epithelial(140;0.000633)		GCAGGGAGGGGACCCAGGAAG	0.667													30	12					0	0	0	0	A	140007428	A	A	140007428	3	1	122	1	0	0	0	0	1	0	0	0	4753	1174	41	2	659	2	DPP7	9	140007428	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	16198879	140007428	1206003	254	21701											
ZMYND11	10771	broad.mit.edu	37	chr10	294371	294371	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccgtgtcaactcagacaaaGaagttaagtgcctcttcacc	12	10	7	12	1	4	2	3	0	1	2	5	2	5	2	3	0	2	1	3	0	4	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:294371G>A	uc010pzt.1	+	13	1751	c.1323G>A	c.(1321-1323)AAG>AAA	p.K441K	ZMYND11_uc001ifk.2_Silent_p.K440K|ZMYND11_uc010pzu.1_Silent_p.K441K|ZMYND11_uc010pzv.1_Silent_p.K386K|ZMYND11_uc010pzw.1_Silent_p.K356K|ZMYND11_uc001ifm.2_Silent_p.K387K|ZMYND11_uc010pzx.1_Silent_p.K441K|ZMYND11_uc001ifn.2_Silent_p.K387K|ZMYND11_uc009xhg.2_Silent_p.K424K|ZMYND11_uc009xhh.2_Silent_p.K315K|ZMYND11_uc010pzy.1_Silent_p.K293K	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	401					cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CTCAGACAAAGAAGTTAAGTG	0.488													48	66					0	0	0	0	A	294371	A	A	294371	2	1	122	1	0	0	0	0	0	0	0	1	17773	933	33	2		2	ZMYND11	10	294371	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08		294371	135240376	255	21702											
GDI2	2665	broad.mit.edu	37	chr10	5807996	5807996	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccccatagatgtcattcttCttgcgcttcatttcctcaaa	8	16	4	13	1	5	1	3	0	2	1	7	1	7	1	3	0	1	1	3	0	2	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:5807996C>G	uc001iil.3	-	11	1602	c.1311G>C	c.(1309-1311)AAG>AAC	p.K437N	GDI2_uc001iim.3_Missense_Mutation_p.K392N|GDI2_uc009xid.2_Missense_Mutation_p.K441N	NM_001494	NP_001485	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2 isoform 1	437					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity				0						TGTCATTCTTCTTGCGCTTCA	0.338													56	103					0	0	0	0	G	5807996	G	G	5807996	3	3	122	1	0	0	0	0	1	0	0	0	6358	912	32	2	30	2	GDI2	10	5807996	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	5513625	5807996	129726751	256	21703											
PFKFB3	5209	broad.mit.edu	37	chr10	6263358	6263358	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcagtttgccagtgctctGagcaagttcgtggaggagca	8	11	13	9	1	2	1	1	1	2	0	4	3	2	3	1	2	4	5	1	2	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:6263358G>C	uc001ije.2	+	9	1230	c.846G>C	c.(844-846)CTG>CTC	p.L282L	PFKFB3_uc001ijd.2_Silent_p.L262L|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Silent_p.L296L|PFKFB3_uc001ijf.2_Silent_p.L282L|PFKFB3_uc001ijg.2_5'Flank|PFKFB3_uc009xij.2_5'Flank|PFKFB3_uc009xik.2_5'Flank|PFKFB3_uc009xil.2_5'Flank	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	282	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(2)|central_nervous_system(1)	3						CCAGTGCTCTGAGCAAGTTCG	0.647													14	14					0	0	0	0	C	6263358	C	C	6263358	2	2	122	1	0	0	0	0	0	0	0	1	11817	1277	45	2		2	PFKFB3	10	6263358	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	455362	6263358	129271389	257	21704											
DHTKD1	55526	broad.mit.edu	37	chr10	12155015	12155015	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacagatggtccggaacttCagaaaaccactcattgttgc	13	9	9	10	1	2	3	2	0	0	3	3	4	3	4	2	2	3	1	2	2	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:12155015C>T	uc001ild.3	+	13	2370	c.2271C>T	c.(2269-2271)TTC>TTT	p.F757F		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	757					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			TCCGGAACTTCAGAAAACCAC	0.478													39	84					0	0	0	0	T	12155015	T	T	12155015	2	4	122	1	0	0	0	0	0	0	0	1	4522	825	29	2		2	DHTKD1	10	12155015	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	5891657	12155015	123379732	258	21705											
ABI1	10006	broad.mit.edu	37	chr10	27048155	27048155	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catactgggaaccaggagctGagcccggggctgctgaaaag	11	5	15	10	1	0	2	0	2	0	0	0	4	0	4	2	4	5	3	2	4	4	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:27048155G>A	uc001isx.2	-	9	1081	c.914C>T	c.(913-915)TCA>TTA	p.S305L	ABI1_uc001ite.2_Missense_Mutation_p.S272L|ABI1_uc010qdh.1_Intron|ABI1_uc010qdi.1_Intron|ABI1_uc001isy.2_Missense_Mutation_p.S278L|ABI1_uc001ita.2_Missense_Mutation_p.S278L|ABI1_uc001isz.2_Missense_Mutation_p.S273L|ABI1_uc001itb.2_Missense_Mutation_p.S322L|ABI1_uc001itc.2_Missense_Mutation_p.S277L|ABI1_uc010qdj.1_Intron|ABI1_uc001itd.2_Missense_Mutation_p.S277L|ABI1_uc010qdk.1_Intron|ABI1_uc010qdg.1_Missense_Mutation_p.S144L	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a	305	Pro-rich.				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						ACCAGGAGCTGAGCCCGGGGC	0.498													28	56					0	0	0	0	A	27048155	A	A	27048155	3	1	122	1	0	0	0	0	1	0	0	0	88	1294	45	2	628	2	ABI1	10	27048155	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	14893140	27048155	108486592	259	21706											
ANKRD26	22852	broad.mit.edu	37	chr10	27326148	27326148	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttttgagccatttcaatCtccttttgtttggaaaggtg	7	19	8	7	0	3	1	1	1	2	0	4	2	3	2	2	2	1	1	2	2	2	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:27326148C>G	uc001ith.2	-	23	2833	c.2661G>C	c.(2659-2661)GAG>GAC	p.E887D	ANKRD26_uc001itg.2_Missense_Mutation_p.E574D|ANKRD26_uc009xku.1_Missense_Mutation_p.E888D	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	887						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						CCATTTCAATCTCCTTTTGTT	0.328													34	84					0	0	0	0	G	27326148	G	G	27326148	3	3	122	1	0	0	0	0	1	0	0	0	654	912	32	2	2516	2	ANKRD26	10	27326148	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	277993	27326148	108208599	260	21707											
RET	5979	broad.mit.edu	37	chr10	43619153	43619153	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgctgtgggagatcgtgAccctagggggaaacccctat	8	9	13	11	1	0	2	0	1	0	1	2	4	1	3	4	3	2	1	4	3	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:43619153A>G	uc001jal.2	+	17	3026	c.2836A>G	c.(2836-2838)ACC>GCC	p.T946A	RET_uc001jak.1_Missense_Mutation_p.T946A|RET_uc010qez.1_Missense_Mutation_p.T692A	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	946	Protein kinase.|Cytoplasmic (Potential).		T -> M (in MEN2B and MTC; familial form).		homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	GGAGATCGTGACCCTAGGGGG	0.612		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				73	104					0	0	0	0	G	43619153	G	G	43619153	3	3	122	1	0	0	0	0	1	0	0	0	13300	275	10	5	2902	5	RET	10	43619153	Missense_Mutation	SNP	A	TCGA-CR-6472-01A-11D-1870-08	16293005	43619153	91915594	261	21708											
STOX1	219736	broad.mit.edu	37	chr10	70645407	70645407	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagaaaatgaggtaattcctGaagtcttgaggaaaagtcat	16	10	11	4	0	2	4	1	3	1	1	3	6	3	5	1	2	0	1	1	2	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:70645407G>A	uc001jos.2	+	3	1942	c.1855G>A	c.(1855-1857)GAA>AAA	p.E619K	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Missense_Mutation_p.E509K	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	619						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						GGTAATTCCTGAAGTCTTGAG	0.443													27	80					0	0	0	0	A	70645407	A	A	70645407	3	1	122	1	0	0	0	0	1	0	0	0	15385	1291	45	2	1865	2	STOX1	10	70645407	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	27026254	70645407	64889340	262	21709											
COL13A1	1305	broad.mit.edu	37	chr10	71690269	71690269	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacccagggagcccaggagaGaagggggaaaaaggggagac	15	0	18	8	0	0	2	0	0	0	2	0	7	0	5	2	6	1	0	2	6	3	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:71690269G>C	uc001jpr.1	+	28	2147	c.1611G>C	c.(1609-1611)GAG>GAC	p.E537D	COL13A1_uc001jqj.1_Missense_Mutation_p.E537D|COL13A1_uc001jps.1_Missense_Mutation_p.E508D|COL13A1_uc001jpt.1_Missense_Mutation_p.E496D|COL13A1_uc001jpu.1_Missense_Mutation_p.E518D|COL13A1_uc001jpv.1_Missense_Mutation_p.E537D|COL13A1_uc001jpx.1_Missense_Mutation_p.E515D|COL13A1_uc001jpw.1_Missense_Mutation_p.E484D|COL13A1_uc001jpy.1_Missense_Mutation_p.E475D|COL13A1_uc001jpz.1_Missense_Mutation_p.E480D|COL13A1_uc001jqa.1_Missense_Mutation_p.E477D|COL13A1_uc001jqc.1_Missense_Mutation_p.E537D|COL13A1_uc001jqb.1_Missense_Mutation_p.E486D|COL13A1_uc001jql.2_Missense_Mutation_p.E537D|COL13A1_uc001jqd.1_Missense_Mutation_p.E525D|COL13A1_uc001jqe.1_Missense_Mutation_p.E520D|COL13A1_uc001jqf.1_Missense_Mutation_p.E518D|COL13A1_uc001jqg.1_Missense_Mutation_p.E515D|COL13A1_uc001jqh.1_Missense_Mutation_p.E537D|COL13A1_uc001jqi.1_Missense_Mutation_p.E537D|COL13A1_uc010qjf.1_Missense_Mutation_p.E327D	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	537	Extracellular (Potential).|Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	GCCCAGGAGAGAAGGGGGAAA	0.627													13	23					0	0	0	0	C	71690269	C	C	71690269	3	2	122	1	0	0	0	0	1	0	0	0	3685	933	33	2	1725	2	COL13A1	10	71690269	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1044862	71690269	63844478	263	21710											
PPP3CB	5532	broad.mit.edu	37	chr10	75230956	75230956	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaatgcaggtggctctttGaatctatctaactgtgaaag	12	12	9	8	0	3	2	0	2	3	0	3	2	3	2	1	2	2	2	1	2	5	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:75230956G>A	uc001jue.2	-	6	816	c.681C>T	c.(679-681)TTC>TTT	p.F227F	PPP3CB_uc001juf.2_Silent_p.F227F|PPP3CB_uc001jug.2_Silent_p.F227F|PPP3CB_uc001jui.2_Silent_p.F245F|PPP3CB_uc001juh.2_Silent_p.F141F	NM_021132	NP_066955	P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta	227	Catalytic.									skin(1)	1	Prostate(51;0.0119)					GTGGCTCTTTGAATCTATCTA	0.343													22	53					0	0	0	0	A	75230956	A	A	75230956	2	1	122	1	0	0	0	0	0	0	0	1	12458	1281	45	2		2	PPP3CB	10	75230956	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3540687	75230956	60303791	264	21711											
SEC24C	9632	broad.mit.edu	37	chr10	75525644	75525644	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctatccctgggctcttatGaattcttggccactgtagat	8	14	9	10	0	2	2	0	1	2	1	3	2	3	2	2	2	1	3	2	2	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:75525644G>T	uc001juw.2	+	11	1632	c.1453G>T	c.(1453-1455)GAA>TAA	p.E485*	SEC24C_uc010qkn.1_Intron|SEC24C_uc009xrj.1_Nonsense_Mutation_p.E343*|SEC24C_uc001jux.2_Nonsense_Mutation_p.E485*|SEC24C_uc010qko.1_Nonsense_Mutation_p.E366*|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	485					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					GGGCTCTTATGAATTCTTGGC	0.507													73	129					3.54697e-40	3.92789e-40	1	0	T	75525644	T	T	75525644	4	4	122	1	0	0	0	0	0	1	0	0	14061	1291	45	2	1487	2	SEC24C	10	75525644	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	294688	75525644	60009103	265	21712											
AP3M1	26985	broad.mit.edu	37	chr10	75897965	75897965	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagcttatcccggtagataCtgatgaggtagtggtgaggt	10	11	15	5	1	0	5	0	3	0	2	1	5	1	5	1	4	2	3	1	4	4	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:75897965C>T	uc001jwf.2	-	2	603	c.173G>A	c.(172-174)AGT>AAT	p.S58N	AP3M1_uc001jwg.2_Missense_Mutation_p.S58N|AP3M1_uc001jwh.2_Missense_Mutation_p.S58N|AP3M1_uc010qla.1_Missense_Mutation_p.S58N	NM_207012	NP_996895	Q9Y2T2	AP3M1_HUMAN	adaptor-related protein complex 3, mu 1 subunit	58					protein targeting to lysosome|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus|lysosome	protein binding				0	Prostate(51;0.0112)					CCGGTAGATACTGATGAGGTA	0.428													30	48					0	0	0	0	T	75897965	T	T	75897965	3	4	122	1	0	0	0	0	1	0	0	0	747	565	20	4	1115	4	AP3M1	10	75897965	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	372321	75897965	59636782	266	21713											
CPEB3	22849	broad.mit.edu	37	chr10	93902855	93902855	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacgagaggtccaaacctgcGaaagctggcagtgatctcat	12	8	11	10	2	1	2	1	1	1	1	3	4	2	2	2	2	4	2	2	2	3	1	rs141047227		TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:93902855G>A	uc001khw.1	-	6	1557	c.1384C>T	c.(1384-1386)CGC>TGC	p.R462C	CPEB3_uc001khu.1_Missense_Mutation_p.R471C|CPEB3_uc001khv.1_Missense_Mutation_p.R448C|CPEB3_uc010qnn.1_Missense_Mutation_p.R448C	NM_014912	NP_055727	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding	462	RRM 1.						nucleotide binding|RNA binding				0		Colorectal(252;0.0869)				CCAAACCTGCGAAAGCTGGCA	0.388													27	46					0	0	0	0	A	93902855	A	A	93902855	3	1	122	1	0	0	0	0	1	0	0	0	3817	1058	37	1	732	1	CPEB3	10	93902855	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	18004890	93902855	41631892	267	21714											
RRP12	23223	broad.mit.edu	37	chr10	99120333	99120333	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agggggtatctccagctcctCctcctcagcctctttctggt	4	13	9	15	0	4	0	1	0	3	0	8	0	7	0	5	3	2	2	5	3	1	2	rs116818150	by1000genomes	TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:99120333C>T	uc001knf.2	-	31	3749	c.3610G>A	c.(3610-3612)GAG>AAG	p.E1204K	RRP12_uc001kne.2_Missense_Mutation_p.E219K|RRP12_uc009xvl.2_Missense_Mutation_p.E321K|RRP12_uc009xvm.2_Missense_Mutation_p.E922K|RRP12_uc010qou.1_Missense_Mutation_p.E1143K|RRP12_uc009xvn.2_Missense_Mutation_p.E1104K	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	1204						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TCCAGCTCCTCCTCCTCAGCC	0.557													35	55					0	0	0	0	T	99120333	T	T	99120333	3	4	122	1	0	0	0	0	1	0	0	0	13751	864	30	2	299	2	RRP12	10	99120333	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	5217478	99120333	36414414	268	21715											
TAF5	6877	broad.mit.edu	37	chr10	105139422	105139422	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctttggatgacgaggatGaagagggagaaaatgaagaa	17	7	14	3	1	0	6	0	3	0	3	0	10	0	8	1	3	1	0	1	3	6	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:105139422G>T	uc001kwv.2	+	4	1194	c.1171G>T	c.(1171-1173)GAA>TAA	p.E391*	TAF5_uc010qqq.1_Nonsense_Mutation_p.E391*	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	391					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		TGACGAGGATGAAGAGGGAGA	0.323													11	23					3.27435e-08	3.39303e-08	1	0	T	105139422	T	T	105139422	4	4	122	1	0	0	0	0	0	1	0	0	15594	1291	45	2	1185	2	TAF5	10	105139422	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	6019089	105139422	30395325	269	21716											
INPP5F	22876	broad.mit.edu	37	chr10	121541174	121541174	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggtggcttattctaattcGgcagaaagcattggtgggca	10	12	13	6	1	1	1	0	0	1	1	2	1	1	1	0	5	1	4	0	5	3	5	rs150684982		TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:121541174G>C	uc001leo.2	+	3	372	c.206G>C	c.(205-207)CGG>CCG	p.R69P	INPP5F_uc001len.3_Missense_Mutation_p.R69P	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	69							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		ATTCTAATTCGGCAGAAAGCA	0.423													15	41					0	0	0	0	C	121541174	C	C	121541174	3	2	122	1	0	0	0	0	1	0	0	0	7797	1116	39	3	216	3	INPP5F	10	121541174	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	16401752	121541174	13993573	270	21717											
JAKMIP3	282973	broad.mit.edu	37	chr10	133930719	133930719	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagctacaggctgtgcgtGagacgctgctgcggcagcat	8	7	16	10	3	0	1	0	1	0	1	0	3	0	2	0	3	6	6	0	3	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr10:133930719G>A	uc001lkx.3	+	2	274	c.274G>A	c.(274-276)GAG>AAG	p.E92K		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GGCTGTGCGTGAGACGCTGCT	0.597													14	36					0	0	0	0	A	133930719	A	A	133930719	3	1	122	1	0	0	0	0	1	0	0	0	7981	1291	45	2	280	2	JAKMIP3	10	133930719	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	12389545	133930719	1604028	271	21718											
TALDO1	6888	broad.mit.edu	37	chr11	747535	747535	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtccgcgctggaccagctCaagcagttcaccaccgtggt	8	7	12	14	3	2	0	2	0	0	0	3	2	3	1	4	2	2	4	4	2	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:747535C>G	uc001lqz.2	+	1	104	c.54C>G	c.(52-54)CTC>CTG	p.L18L	TALDO1_uc010qwl.1_Silent_p.L18L|TALDO1_uc001lra.2_Silent_p.L18L	NM_006755	NP_006746	P37837	TALDO_HUMAN	transaldolase 1	18					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		TGGACCAGCTCAAGCAGTTCA	0.602													5	9					0	0	0	0	G	747535	G	G	747535	2	3	122	1	0	0	0	0	0	0	0	1	15609	813	29	2		2	TALDO1	11	747535	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08		747535	134258981	272	21719											
ZNF214	7761	broad.mit.edu	37	chr11	7022289	7022289	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccattgaatctctcagtaGgtcttcttgacatatcaccc	9	15	5	12	0	5	2	2	2	3	0	7	2	6	2	2	1	0	1	2	1	3	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:7022289G>C	uc001mfa.2	-	3	928	c.625C>G	c.(625-627)CTA>GTA	p.L209V	ZNF214_uc010ray.1_Missense_Mutation_p.L209V|ZNF214_uc009yfh.1_Missense_Mutation_p.L209V	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TCTCTCAGTAGGTCTTCTTGA	0.398													40	19					0	0	0	0	C	7022289	C	C	7022289	3	2	122	1	0	0	0	0	1	0	0	0	17837	991	35	4	1199	4	ZNF214	11	7022289	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	6274754	7022289	127984227	273	21720											
USP47	55031	broad.mit.edu	37	chr11	11924275	11924275	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaataggtgggaatttgaaGaatctgaagaagatccagtg	15	11	12	3	0	1	5	0	2	1	3	2	6	2	6	1	2	0	0	1	2	7	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:11924275G>A	uc001mjq.1	+	7	1430	c.667G>A	c.(667-669)GAA>AAA	p.E223K	USP47_uc001mjr.2_Missense_Mutation_p.E135K|USP47_uc001mjs.2_Missense_Mutation_p.E203K	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	223					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		GGAATTTGAAGAATCTGAAGA	0.244													22	11					0	0	0	0	A	11924275	A	A	11924275	3	1	122	1	0	0	0	0	1	0	0	0	17146	943	33	2	421	2	USP47	11	11924275	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4901986	11924275	123082241	274	21721											
MRGPRX1	259249	broad.mit.edu	37	chr11	18956206	18956206	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcacaactgcgtttcctgtCagcccgacaagggaaacgat	12	7	10	12	3	1	0	1	0	0	0	2	3	2	1	2	1	5	2	2	1	3	1	rs147529961	byFrequency	TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:18956206C>T	uc001mpg.2	-	1	344	c.126G>A	c.(124-126)CTG>CTA	p.L42L		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	42	Helical; Name=1; (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						CGTTTCCTGTCAGCCCGACAA	0.562													54	108					0	0	0	0	T	18956206	T	T	18956206	2	4	122	1	0	0	0	0	0	0	0	1	9819	813	29	2		2	MRGPRX1	11	18956206	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	7031931	18956206	116050310	275	21722											
E2F8	79733	broad.mit.edu	37	chr11	19247323	19247332	+	Frame_Shift_Del	DEL	CTTGAGTTTT	-	-																															tgtggtttggggaaagagcaCttgagttttctttaccagac																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:19247323_19247332delCTTGAGTTTT	uc001mpm.2	-	11	2495_2504	c.1973_1982delAAAACTCAAG	c.(1972-1983)GAAAACTCAAGTfs	p.E658fs	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Frame_Shift_Del_p.E658fs	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	658_661					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						GGAAAGAGCACTTGAGTTTTCTTTACCAGA	0.49													---	---	---								-	19247332	-	-	19247323	7	5	122	1	0	1	0	1	0	0	0	0	4895	565	20	0	633	0	E2F8	11	19247323	Frame_Shift_Del	DEL	CTTGAGTTTT	TCGA-CR-6472-01A-11D-1870-08	291117	19247323	115759193	276	21723											
NELL1	4745	broad.mit.edu	37	chr11	21581825	21581825	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttgactgtctctgcccctCtgggccctcctgctctggtg	1	14	10	16	0	3	1	0	1	3	0	5	1	4	1	4	2	2	1	4	2	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:21581825C>T	uc001mqe.2	+	17	2030	c.1877C>T	c.(1876-1878)TCT>TTT	p.S626F	NELL1_uc001mqf.2_Missense_Mutation_p.S579F|NELL1_uc009yid.2_Missense_Mutation_p.S654F|NELL1_uc010rdo.1_Missense_Mutation_p.S569F|NELL1_uc010rdp.1_Missense_Mutation_p.S339F|NELL1_uc001mqh.2_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	626	EGF-like 6; calcium-binding (Potential).			S -> C (in Ref. 7; AAB06946).	cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						CTCTGCCCCTCTGGGCCCTCC	0.537													29	24					0	0	0	0	T	21581825	T	T	21581825	3	4	122	1	0	0	0	0	1	0	0	0	10387	913	32	2	1943	2	NELL1	11	21581825	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2334502	21581825	113424691	277	21724											
QSER1	79832	broad.mit.edu	37	chr11	32953947	32953947	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacggaggattacaacagaaGacctcccaggtctcagtgga	14	6	11	10	1	1	2	1	0	1	2	3	5	2	5	2	4	3	0	2	4	4	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:32953947G>C	uc001mty.2	+	4	1023	c.756G>C	c.(754-756)AAG>AAC	p.K252N	QSER1_uc001mtz.1_Intron|QSER1_uc001mua.2_5'Flank	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	252	Ser-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					TACAACAGAAGACCTCCCAGG	0.438													30	46					0	0	0	0	C	32953947	C	C	32953947	3	2	122	1	0	0	0	0	1	0	0	0	12947	933	33	2	762	2	QSER1	11	32953947	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	11372122	32953947	102052569	278	21725											
HIPK3	10114	broad.mit.edu	37	chr11	33308711	33308711	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattagcaaggctcagtactGaaaatgctgatgaatataac	16	11	8	6	0	1	3	1	3	0	0	1	3	1	3	0	1	4	4	0	1	9	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:33308711G>A	uc001mul.1	+	2	1021	c.751G>A	c.(751-753)GAA>AAA	p.E251K	HIPK3_uc001mum.1_Missense_Mutation_p.E251K|HIPK3_uc009yjv.1_Missense_Mutation_p.E251K	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	251	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						GCTCAGTACTGAAAATGCTGA	0.363													24	30					0	0	0	0	A	33308711	A	A	33308711	3	1	122	1	0	0	0	0	1	0	0	0	7157	1291	45	2	753	2	HIPK3	11	33308711	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	354764	33308711	101697805	279	21726											
OR5D14	219436	broad.mit.edu	37	chr11	55563457	55563457	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggccatgtcacagaggctCtgtgccctgctggtggctgg	4	10	16	11	0	2	1	1	0	1	1	2	1	2	1	2	5	2	3	2	5	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:55563457C>T	uc010rim.1	+	1	426	c.426C>T	c.(424-426)CTC>CTT	p.L142L		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				CACAGAGGCTCTGTGCCCTGC	0.517													32	50					0	0	0	0	T	55563457	T	T	55563457	2	4	122	1	0	0	0	0	0	0	0	1	11209	900	32	2		2	OR5D14	11	55563457	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	22254746	55563457	79443059	280	21727											
OR8I2	120586	broad.mit.edu	37	chr11	55860932	55860932	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggactgatcacgttaatcaGaatggattctcagcttcaca	12	11	9	9	1	4	2	4	1	1	1	5	4	4	4	0	2	1	2	0	2	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:55860932G>A	uc010rix.1	+	1	149	c.149G>A	c.(148-150)AGA>AAA	p.R50K		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					ACGTTAATCAGAATGGATTCT	0.373													95	155					0	0	0	0	A	55860932	A	A	55860932	3	1	122	1	0	0	0	0	1	0	0	0	11294	942	33	2	151	2	OR8I2	11	55860932	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	297475	55860932	79145584	281	21728											
LRRC55	219527	broad.mit.edu	37	chr11	56950027	56950027	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgggggcctggccttcctCagcctggaggctcttgaggg	4	10	16	11	0	2	1	1	1	1	0	3	2	3	2	4	6	1	1	4	6	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:56950027C>T	uc001njl.1	+	1	807	c.660C>T	c.(658-660)CTC>CTT	p.L220L		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	190	LRR 5.					integral to membrane					0						TGGCCTTCCTCAGCCTGGAGG	0.652													34	49					0	0	0	0	T	56950027	T	T	56950027	2	4	122	1	0	0	0	0	0	0	0	1	9061	813	29	2		2	LRRC55	11	56950027	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1089095	56950027	78056489	282	21729											
C11orf31	280636	broad.mit.edu	37	chr11	57509396	57509396	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agccccggaggggcagcttcGaggtgacgctgctgcgcccg	5	5	17	14	5	0	1	0	1	0	0	1	3	0	2	3	4	4	4	3	4	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:57509396G>C	uc010rjx.1	+	3	584	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	CTNND1_uc001nlf.1_Intron	NM_170746	NP_734467	Q8IZQ5	SELH_HUMAN	selenoprotein H	80					cell redox homeostasis		selenium binding				0						GGGCAGCTTCGAGGTGACGCT	0.677													5	6					0	0	0	0	C	57509396	C	C	57509396	3	2	122	1	0	0	0	0	1	0	0	0	1643	1059	37	3	244	3	C11orf31	11	57509396	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	559369	57509396	77497120	283	21730											
OR5B17	219965	broad.mit.edu	37	chr11	58126450	58126450	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcagagtgatgaggtagatGagggtaaacatgataaagag	16	8	15	2	0	1	7	1	4	0	3	1	7	1	7	0	2	1	2	0	2	5	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:58126450G>A	uc010rke.1	-	1	93	c.93C>T	c.(91-93)CTC>CTT	p.L31L		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGAGGTAGATGAGGGTAAACA	0.443													60	89					0	0	0	0	A	58126450	A	A	58126450	2	1	122	1	0	0	0	0	0	0	0	1	11203	1277	45	2		2	OR5B17	11	58126450	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	617054	58126450	76880066	284	21731											
FAM111A	63901	broad.mit.edu	37	chr11	58920182	58920182	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcttcgattaaagtagtGaaacttcttgtacgtctcag	10	16	7	8	2	4	1	1	1	4	0	6	2	4	1	0	0	2	2	0	0	5	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:58920182G>T	uc010rkp.1	+	5	1268	c.1041G>T	c.(1039-1041)GTG>GTT	p.V347V	FAM111A_uc010rkq.1_Silent_p.V347V|FAM111A_uc010rkr.1_Silent_p.V347V|FAM111A_uc001nno.2_Silent_p.V347V|FAM111A_uc001nnp.2_Silent_p.V347V|FAM111A_uc001nnq.2_Silent_p.V347V	NM_001142521	NP_001135993	Q96PZ2	F111A_HUMAN	hypothetical protein LOC63901	347					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_epithelial(135;0.139)				TTAAAGTAGTGAAACTTCTTG	0.348													34	53					4.34311e-12	4.58358e-12	1	0	T	58920182	T	T	58920182	2	4	122	1	0	0	0	0	0	0	0	1	5427	1277	45	2		2	FAM111A	11	58920182	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	793732	58920182	76086334	285	21732											
SDHAF2	54949	broad.mit.edu	37	chr11	61205277	61205277	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagagcccgcctgctctatGagagcagaaagaggggaatg	14	5	14	8	1	1	4	0	1	1	4	1	6	1	5	2	2	3	2	2	2	4	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:61205277G>A	uc001nrt.2	+	2	239	c.217G>A	c.(217-219)GAG>AAG	p.E73K		NM_017841	NP_060311	Q9NX18	SDHF2_HUMAN	succinate dehydrogenase complex assembly factor	73					mitochondrial electron transport, succinate to ubiquinone|protein-FAD linkage	mitochondrion	protein binding			ovary(2)	2						CCTGCTCTATGAGAGCAGAAA	0.373									Familial_Paragangliomas				38	77					0	0	0	0	A	61205277	A	A	61205277	3	1	122	1	0	0	0	0	1	0	0	0	14029	1291	45	2	223	2	SDHAF2	11	61205277	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2285095	61205277	73801239	286	21733											
C11orf9	745	broad.mit.edu	37	chr11	61543821	61543821	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgccccctgagcaggtcacGaaggtgactgtggggcggct	6	7	16	12	2	1	2	1	2	0	0	1	3	1	2	2	5	2	2	2	5	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:61543821G>A	uc001nsc.1	+	10	1512	c.1416G>A	c.(1414-1416)ACG>ACA	p.T472T	C11orf9_uc001nse.1_Silent_p.T463T|C11orf9_uc010rll.1_5'Flank	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	472	NDT80.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						AGCAGGTCACGAAGGTGACTG	0.657											OREG0021012	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	10					0	0	0	0	A	61543821	A	A	61543821	2	1	122	1	0	0	0	0	0	0	0	1	1677	1045	37	1		1	C11orf9	11	61543821	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	338544	61543821	73462695	287	21734											
MTA2	9219	broad.mit.edu	37	chr11	62365499	62365499	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgtcctgttgcttaccctCtactaggcgatctgggatct	5	15	9	12	1	3	0	0	0	3	0	4	2	4	1	2	2	3	2	2	2	3	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:62365499C>A	uc001ntq.1	-	6	868	c.487G>T	c.(487-489)GAG>TAG	p.E163*	MTA2_uc010rlx.1_5'UTR	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	163	ELM2.				chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TGCTTACCCTCTACTAGGCGA	0.313													58	155					7.05995e-25	7.73643e-25	1	0	A	62365499	A	A	62365499	4	1	122	1	0	0	0	0	0	1	0	0	9962	922	32	2	1571	2	MTA2	11	62365499	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	821678	62365499	72641017	288	21735											
MTA2	9219	broad.mit.edu	37	chr11	62365820	62365820	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccttttccaggtactggctCaagatatctgtctcattcaa	9	15	6	11	0	4	1	3	0	2	1	7	1	6	1	2	2	1	2	2	2	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:62365820C>G	uc001ntq.1	-	5	732	c.351G>C	c.(349-351)TTG>TTC	p.L117F	MTA2_uc010rlx.1_5'UTR	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	117	BAH.				chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGTACTGGCTCAAGATATCTG	0.517													181	348					0	0	0	0	G	62365820	G	G	62365820	3	3	122	1	0	0	0	0	1	0	0	0	9962	825	29	2	1711	2	MTA2	11	62365820	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	321	62365820	72640696	289	21736											
STX5	6811	broad.mit.edu	37	chr11	62575026	62575026	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaccggttggaggtgacaGactggaagtacttgaggatc	10	8	15	8	1	0	3	0	2	0	1	1	6	0	6	2	5	1	2	2	5	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:62575026G>T	uc001nvh.2	-	11	1137	c.983C>A	c.(982-984)TCT>TAT	p.S328Y	NXF1_uc001nvf.1_5'Flank|NXF1_uc001nvg.1_5'Flank|NXF1_uc009yog.1_5'Flank|NXF1_uc010rmh.1_5'Flank|STX5_uc010rmi.1_Missense_Mutation_p.S232Y|STX5_uc009yoh.2_RNA|STX5_uc001nvi.2_Missense_Mutation_p.S274Y|STX5_uc010rmj.1_3'UTR|STX5_uc001nvj.2_Missense_Mutation_p.S143Y	NM_003164	NP_003155	Q13190	STX5_HUMAN	syntaxin 5	328	Cytoplasmic (Potential).				intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			ovary(1)|breast(1)	2						GGAGGTGACAGACTGGAAGTA	0.532													14	24					7.93312e-07	8.19365e-07	1	0	T	62575026	T	T	62575026	3	4	122	1	0	0	0	0	1	0	0	0	15414	942	33	2	88	2	STX5	11	62575026	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	209206	62575026	72431490	290	21737											
RTN3	10313	broad.mit.edu	37	chr11	63487851	63487851	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttaatgagacagaattctCattaaatgtgacaacatctg	15	14	6	6	0	2	3	1	2	2	2	3	4	2	3	0	0	1	0	0	0	5	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:63487851C>A	uc001nxq.2	+	3	2064	c.1877C>A	c.(1876-1878)TCA>TAA	p.S626*	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Nonsense_Mutation_p.S607*|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Nonsense_Mutation_p.S514*|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	626					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						ACAGAATTCTCATTAAATGTG	0.388													40	62					5.59293e-11	5.88286e-11	1	0	A	63487851	A	A	63487851	4	1	122	1	0	0	0	0	0	1	0	0	13792	838	29	2	1887	2	RTN3	11	63487851	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	912825	63487851	71518665	291	21738											
CDC42BPG	55561	broad.mit.edu	37	chr11	64603995	64603995	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacaatgaggccttgtccctCagcatctctgccaggaagag	10	8	11	12	0	2	2	1	1	1	1	4	4	3	3	3	2	2	1	3	2	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:64603995C>G	uc001obs.3	-	12	1392	c.1392G>C	c.(1390-1392)CTG>CTC	p.L464L		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	464	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						CCTTGTCCCTCAGCATCTCTG	0.602											OREG0004017	type=REGULATORY REGION|Gene=CDC42BPG|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	22	38					0	0	0	0	G	64603995	G	G	64603995	2	3	122	1	0	0	0	0	0	0	0	1	3089	813	29	2		2	CDC42BPG	11	64603995	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1116144	64603995	70402521	292	21739											
ATG2A	23130	broad.mit.edu	37	chr11	64662529	64662529	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggttgcgcatgcccccgagCaggctggacgtggcctccgt	4	8	15	14	4	0	0	0	0	0	0	1	2	1	1	4	4	3	4	4	4	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:64662529C>G	uc001obx.2	-	41	5848	c.5733G>C	c.(5731-5733)CTG>CTC	p.L1911L	uc009ypx.2_5'Flank|ATG2A_uc001obw.2_Silent_p.L676L	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1911							protein binding			ovary(1)|central_nervous_system(1)	2						TGCCCCCGAGCAGGCTGGACG	0.706													23	47					0	0	0	0	G	64662529	G	G	64662529	2	3	122	1	0	0	0	0	0	0	0	1	1095	697	25	4		4	ATG2A	11	64662529	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	58534	64662529	70343987	293	21740											
TBC1D10C	374403	broad.mit.edu	37	chr11	67177168	67177168	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgggcccggggcccccccatCgaggggccccccaggcccca	4	1	14	22	3	0	0	0	0	0	0	1	1	0	0	9	6	0	0	9	6	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:67177168C>G	uc001ola.2	+	10	1313	c.1284C>G	c.(1282-1284)ATC>ATG	p.I428M	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_3'UTR|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	428	Interaction with calcineurin.					intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCCCCCCCATCGAGGGGCCCC	0.682													11	25					0	0	0	0	G	67177168	G	G	67177168	3	3	122	1	0	0	0	0	1	0	0	0	15666	874	31	3	1318	3	TBC1D10C	11	67177168	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2514639	67177168	67829348	294	21741											
TBC1D10C	374403	broad.mit.edu	37	chr11	67177203	67177203	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gccccaacgaggctccacctCcttcctggacacccgcttct	6	8	7	20	2	1	0	0	0	1	0	4	2	4	1	7	2	1	2	7	2	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:67177203C>G	uc001ola.2	+	10	1348	c.1319C>G	c.(1318-1320)TCC>TGC	p.S440C	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_3'UTR|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	440	Interaction with calcineurin.					intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GGCTCCACCTCCTTCCTGGAC	0.657													19	22					0	0	0	0	G	67177203	G	G	67177203	3	3	122	1	0	0	0	0	1	0	0	0	15666	855	30	2	1353	2	TBC1D10C	11	67177203	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	35	67177203	67829313	295	21742											
GAL	51083	broad.mit.edu	37	chr11	68456340	68456340	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctttgacaggtccatacctGaaaacaatatcatgcgcaca	14	9	7	11	1	1	2	1	2	0	0	2	2	2	2	2	1	3	2	2	1	5	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:68456340G>C	uc001oob.2	+	5	465	c.247G>C	c.(247-249)GAA>CAA	p.E83Q		NM_015973	NP_057057	P22466	GALA_HUMAN	galanin preproprotein	83					growth hormone secretion|insulin secretion|neuropeptide signaling pathway|smooth muscle contraction	extracellular region	neuropeptide hormone activity				0	Esophageal squamous(3;7.33e-10)	Melanoma(852;0.0749)	LUAD - Lung adenocarcinoma(13;0.0514)	Kidney(183;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.000152)|LUSC - Lung squamous cell carcinoma(976;0.00154)		GTCCATACCTGAAAACAATAT	0.418													5	28					0	0	0	0	C	68456340	C	C	68456340	3	2	122	1	0	0	0	0	1	0	0	0	6231	1291	45	2	261	2	GAL	11	68456340	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1279137	68456340	66550176	296	21743											
CPT1A	1374	broad.mit.edu	37	chr11	68542817	68542817	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcccactgcagcctggtgggGtacggaatgttcggattgat	7	11	14	9	2	0	1	0	1	0	0	2	3	1	3	2	5	3	3	2	5	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:68542817G>A	uc001oog.3	-	13	1712	c.1542C>T	c.(1540-1542)TAC>TAT	p.Y514Y	CPT1A_uc001oof.3_Silent_p.Y514Y|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	514	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GCCTGGTGGGGTACGGAATGT	0.502													44	75					0	0	0	0	A	68542817	A	A	68542817	2	1	122	1	0	0	0	0	0	0	0	1	3846	1256	44	4		4	CPT1A	11	68542817	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	86477	68542817	66463699	297	21744											
FADD	8772	broad.mit.edu	37	chr11	70049837	70049837	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggcggcggccggggccgCgcctggggaagaaggtgggc	4	2	25	10	5	0	1	0	0	0	1	0	2	0	2	3	10	0	0	3	10	2	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:70049837C>T	uc001opm.2	+	1	569	c.272C>T	c.(271-273)GCG>GTG	p.A91V		NM_003824	NP_003815	Q13158	FADD_HUMAN	Fas-associated via death domain	91					activation of caspase activity|activation of pro-apoptotic gene products|cellular response to mechanical stimulus|defense response to virus|induction of apoptosis via death domain receptors|innate immune response|interspecies interaction between organisms|necrotic cell death|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|signal transduction	cytosol	death receptor binding|identical protein binding			ovary(1)|lung(1)|pancreas(1)	3	Esophageal squamous(2;1.19e-45)		LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			gccggggccgcgcctggggaa	0.507													3	12					0	0	0	0	T	70049837	T	T	70049837	3	4	122	1	0	0	0	0	1	0	0	0	5392	768	27	1	274	1	FADD	11	70049837	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1507020	70049837	64956679	298	21745											
PHOX2A	401	broad.mit.edu	37	chr11	71952253	71952253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccagctccttgagctgcgCgctggtgaacgtggtgcgga	5	9	15	12	4	0	2	0	2	0	0	2	3	2	3	2	3	5	3	2	3	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:71952253C>T	uc001osh.3	-	2	470	c.298G>A	c.(298-300)GCG>ACG	p.A100T		NM_005169	NP_005160	O14813	PHX2A_HUMAN	paired-like homeobox 2a	100	Homeobox.				noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTGAGCTGCGCGCTGGTGAAC	0.637													15	23					0	0	0	0	T	71952253	T	T	71952253	3	4	122	1	0	0	0	0	1	0	0	0	11913	768	27	1	564	1	PHOX2A	11	71952253	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1902416	71952253	63054263	299	21746											
RELT	84957	broad.mit.edu	37	chr11	73101849	73101849	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccccccaggcaccttctCagctgcatggggctccagcc	5	7	10	19	0	1	0	1	0	1	0	3	0	2	0	6	3	4	4	6	3	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:73101849C>G	uc001otv.2	+	4	335	c.170C>G	c.(169-171)TCA>TGA	p.S57*	RELT_uc001otw.2_Nonsense_Mutation_p.S57*|RELT_uc009yto.1_5'UTR|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	57	TNFR-Cys.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						GGCACCTTCTCAGCTGCATGG	0.647													22	58					0	0	0	0	G	73101849	G	G	73101849	4	3	122	1	0	0	0	0	0	1	0	0	13286	838	29	2	180	2	RELT	11	73101849	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1149596	73101849	61904667	300	21747											
ZBTB16	7704	broad.mit.edu	37	chr11	113935271	113935271	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggtcgagcttcctgataacGaggctgtggagcagcacagg	9	7	16	9	2	0	1	0	1	0	0	2	4	1	2	1	4	4	4	1	4	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:113935271G>A	uc001pop.2	+	2	1513	c.1249G>A	c.(1249-1251)GAG>AAG	p.E417K	ZBTB16_uc001poo.1_Missense_Mutation_p.E417K|ZBTB16_uc001poq.2_Missense_Mutation_p.E417K	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	417	C2H2-type 1.				apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		TCCTGATAACGAGGCTGTGGA	0.632													21	10					0	0	0	0	A	113935271	A	A	113935271	3	1	122	1	0	0	0	0	1	0	0	0	17593	1059	37	1	1251	1	ZBTB16	11	113935271	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	40833422	113935271	21071245	301	21748											
ZBTB16	7704	broad.mit.edu	37	chr11	114121062	114121062	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcaggtgagaagccctttGagtgtaagctctgccaccag	9	9	11	12	0	2	2	1	2	1	1	2	3	2	2	4	1	3	2	4	1	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:114121062G>C	uc001pop.2	+	7	2071	c.1807G>C	c.(1807-1809)GAG>CAG	p.E603Q	ZBTB16_uc001poq.2_Missense_Mutation_p.E603Q	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	603	C2H2-type 8.				apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		GAAGCCCTTTGAGTGTAAGCT	0.622													21	23					0	0	0	0	C	114121062	C	C	114121062	3	2	122	1	0	0	0	0	1	0	0	0	17593	1291	45	2	1829	2	ZBTB16	11	114121062	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	185791	114121062	20885454	302	21749											
OR8D1	283159	broad.mit.edu	37	chr11	124180474	124180474	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgacgaaggacaagctgctGaggaaatagtacatgggggt	13	7	15	6	2	0	1	0	1	0	0	1	5	0	3	0	4	3	3	0	4	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:124180474G>A	uc010sag.1	-	1	189	c.189C>T	c.(187-189)CTC>CTT	p.L63L		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		ACAAGCTGCTGAGGAAATAGT	0.463													26	24					0	0	0	0	A	124180474	A	A	124180474	2	1	122	1	0	0	0	0	0	0	0	1	11285	1277	45	2		2	OR8D1	11	124180474	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	10059412	124180474	10826042	303	21750											
PUS3	83480	broad.mit.edu	37	chr11	125765351	125765351	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcagatagaatagtcctctGaaaattaatcacaccgttgg	15	10	8	8	1	2	3	1	1	1	2	3	3	3	3	2	1	1	2	2	1	6	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:125765351G>C	uc001qcy.2	-	3	810	c.712C>G	c.(712-714)CAG>GAG	p.Q238E	HYLS1_uc009zbv.2_Intron|HYLS1_uc001qcx.3_Intron	NM_031307	NP_112597	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	238						nucleus	RNA binding			ovary(1)	1	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)		ATAGTCCTCTGAAAATTAATC	0.443													34	18					0	0	0	0	C	125765351	C	C	125765351	3	2	122	1	0	0	0	0	1	0	0	0	12897	1299	45	2	741	2	PUS3	11	125765351	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1584877	125765351	9241165	304	21751											
GLB1L2	89944	broad.mit.edu	37	chr11	134241000	134241000	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctatgagaccagcatcacCtcgtctggcatcctcagtgg	8	10	9	14	1	4	1	2	1	2	1	6	2	5	1	3	2	1	2	3	2	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr11:134241000C>A	uc001qhp.2	+	13	1502	c.1314C>A	c.(1312-1314)ACC>ACA	p.T438T	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	438					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CCAGCATCACCTCGTCTGGCA	0.527													43	81					2.62258e-09	2.74476e-09	1	0	A	134241000	A	A	134241000	2	1	122	1	0	0	0	0	0	0	0	1	6466	668	24	4		4	GLB1L2	11	134241000	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	8475649	134241000	765516	305	21752											
CACNA1C	775	broad.mit.edu	37	chr12	2774867	2774867	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgggcagagtatgaccctGaagccaagtaagttcccaga	12	8	11	10	0	1	4	0	2	1	2	2	4	2	4	3	1	1	4	3	1	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:2774867G>A	uc009zdu.1	+	38	4976	c.4663G>A	c.(4663-4665)GAA>AAA	p.E1555K	CACNA1C_uc009zdv.1_Missense_Mutation_p.E1504K|CACNA1C_uc001qkb.2_Missense_Mutation_p.E1507K|CACNA1C_uc001qkc.2_Missense_Mutation_p.E1507K|CACNA1C_uc001qke.2_Missense_Mutation_p.E1496K|CACNA1C_uc001qkf.2_Missense_Mutation_p.E1496K|CACNA1C_uc001qjz.2_Missense_Mutation_p.E1507K|CACNA1C_uc001qkd.2_Missense_Mutation_p.E1507K|CACNA1C_uc001qkg.2_Missense_Mutation_p.E1494K|CACNA1C_uc009zdw.1_Missense_Mutation_p.E1529K|CACNA1C_uc001qkh.2_Missense_Mutation_p.E1496K|CACNA1C_uc001qkl.2_Missense_Mutation_p.E1555K|CACNA1C_uc001qkn.2_Missense_Mutation_p.E1507K|CACNA1C_uc001qko.2_Missense_Mutation_p.E1527K|CACNA1C_uc001qkp.2_Missense_Mutation_p.E1507K|CACNA1C_uc001qkr.2_Missense_Mutation_p.E1524K|CACNA1C_uc001qku.2_Missense_Mutation_p.E1507K|CACNA1C_uc001qkq.2_Missense_Mutation_p.E1535K|CACNA1C_uc001qks.2_Missense_Mutation_p.E1507K|CACNA1C_uc001qkt.2_Missense_Mutation_p.E1507K|CACNA1C_uc001qki.1_Missense_Mutation_p.E1243K|CACNA1C_uc001qkj.1_Missense_Mutation_p.E1243K|CACNA1C_uc001qkk.1_Missense_Mutation_p.E1243K|CACNA1C_uc001qkm.1_Missense_Mutation_p.E1232K|CACNA1C_uc010sea.1_Missense_Mutation_p.E198K	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1555	Cytoplasmic (Potential).|By similarity.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GTATGACCCTGAAGCCAAGTA	0.517													10	18					0	0	0	0	A	2774867	A	A	2774867	3	1	122	1	0	0	0	0	1	0	0	0	2552	1291	45	2	4987	2	CACNA1C	12	2774867	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08		2774867	131077028	306	21753											
CD27	939	broad.mit.edu	37	chr12	6554306	6554306	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcgttctggggaccctGgtggggctctcagctactcc	3	11	14	13	1	2	0	1	0	2	0	4	1	3	1	2	5	3	3	2	5	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:6554306G>A	uc001qod.2	+	1	256	c.45G>A	c.(43-45)CTG>CTA	p.L15L	LOC678655_uc001qob.2_Intron|LOC678655_uc001qoc.2_Intron|LOC678655_uc009zel.1_Intron|CD27_uc001qoe.2_5'Flank	NM_001242	NP_001233	P26842	CD27_HUMAN	tumor necrosis factor receptor superfamily,	15					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity				0						TGGGGACCCTGGTGGGGCTCT	0.642													9	15					0	0	0	0	A	6554306	A	A	6554306	2	1	122	1	0	0	0	0	0	0	0	1	3005	1335	47	4		4	CD27	12	6554306	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3779439	6554306	127297589	307	21754											
DUSP16	80824	broad.mit.edu	37	chr12	12630651	12630651	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtaccagcgggctgtcctCtaacagcgacggctgcacgc	7	7	12	15	4	1	0	0	0	1	0	2	1	2	0	2	2	5	4	2	2	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:12630651C>G	uc001rao.1	-	7	1746	c.1114G>C	c.(1114-1116)GAG>CAG	p.E372Q	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.E224Q	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	372					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		GGGCTGTCCTCTAACAGCGAC	0.517													23	35					0	0	0	0	G	12630651	G	G	12630651	3	3	122	1	0	0	0	0	1	0	0	0	4838	922	32	2	887	2	DUSP16	12	12630651	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6076345	12630651	121221244	308	21755											
GRIN2B	2904	broad.mit.edu	37	chr12	14019074	14019074	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgagaacgagctctgctGcctgacacggccaggacggc	8	7	13	13	3	2	2	0	2	2	1	2	5	2	3	2	3	4	2	2	3	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:14019074G>C	uc001rbt.2	-	2	248	c.69C>G	c.(67-69)GGC>GGG	p.G23G		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	23					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAGCTCTGCTGCCTGACACGG	0.582													23	34					0	0	0	0	C	14019074	C	C	14019074	2	2	122	1	0	0	0	0	0	0	0	1	6819	1306	46	4		4	GRIN2B	12	14019074	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1388423	14019074	119832821	309	21756											
PIK3C2G	5288	broad.mit.edu	37	chr12	18439791	18439791	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttattttaagtcaataggttGttccattcagctagtggaag	11	16	9	5	0	2	0	2	0	0	0	3	1	3	1	1	2	1	3	1	2	6	8			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:18439791G>C	uc001rdt.2	+	3	805	c.689G>C	c.(688-690)TGT>TCT	p.C230S	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.C230S|PIK3C2G_uc010sic.1_Missense_Mutation_p.C8S	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	230					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				TCAATAGGTTGTTCCATTCAG	0.299													3	8					0	0	0	0	C	18439791	C	C	18439791	3	2	122	1	0	0	0	0	1	0	0	0	11966	1377	48	4	695	4	PIK3C2G	12	18439791	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4420717	18439791	115412104	310	21757											
RECQL	5965	broad.mit.edu	37	chr12	21629873	21629873	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttgtatctcccattaatGagctttacaatatcctcaat	11	16	3	11	0	2	1	1	1	1	0	4	1	3	1	3	0	2	2	3	0	6	6	rs138413466		TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:21629873G>C	uc001rex.2	-	9	1269	c.921C>G	c.(919-921)CTC>CTG	p.L307L	RECQL_uc001rey.2_Silent_p.L307L	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	307	Helicase C-terminal.				DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						TCCCATTAATGAGCTTTACAA	0.318								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					3	23					0	0	0	0	C	21629873	C	C	21629873	2	2	122	1	0	0	0	0	0	0	0	1	13266	1277	45	2		2	RECQL	12	21629873	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3190082	21629873	112222022	311	21758											
C12orf71	728858	broad.mit.edu	37	chr12	27235188	27235188	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaactgctctggttcatcctGaatttggtcttgtctcttca	7	17	7	10	0	5	1	2	1	3	0	7	1	6	1	1	2	2	2	1	2	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:27235188G>C	uc001rhq.2	-	1	268	c.229C>G	c.(229-231)CAG>GAG	p.Q77E		NM_001080406	NP_001073875	A8MTZ7	CL071_HUMAN	hypothetical protein LOC728858	77											0						GGTTCATCCTGAATTTGGTCT	0.507													17	30					0	0	0	0	C	27235188	C	C	27235188	3	2	122	1	0	0	0	0	1	0	0	0	1718	1299	45	2	588	2	C12orf71	12	27235188	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5605315	27235188	106616707	312	21759											
MRPS35	60488	broad.mit.edu	37	chr12	27869326	27869326	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgcagtacctcttcctgttCgaatgggttatccagtaaaa	10	13	8	10	1	1	0	0	0	1	0	4	1	3	0	3	1	2	5	3	1	5	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:27869326C>G	uc001rih.2	+	3	304	c.256C>G	c.(256-258)CGA>GGA	p.R86G	MRPS35_uc001rii.2_Missense_Mutation_p.R86G	NM_021821	NP_068593	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35 precursor	86					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit					0	Lung SC(9;0.0873)					TCTTCCTGTTCGAATGGGTTA	0.433													25	27					0	0	0	0	G	27869326	G	G	27869326	3	3	122	1	0	0	0	0	1	0	0	0	9897	876	31	3	266	3	MRPS35	12	27869326	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	634138	27869326	105982569	313	21760											
LRRK2	120892	broad.mit.edu	37	chr12	40696615	40696615	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgcctttcttgcctccttCtatgacaatcctaaaattat	10	17	3	11	0	2	1	0	1	2	0	4	1	4	1	4	0	2	0	4	0	6	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:40696615C>G	uc001rmg.3	+	26	3642	c.3521C>G	c.(3520-3522)TCT>TGT	p.S1174C	LRRK2_uc001rmh.1_Missense_Mutation_p.S796C|LRRK2_uc009zjw.2_Missense_Mutation_p.S12C|LRRK2_uc001rmi.2_Missense_Mutation_p.S7C	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1174	LRR 8.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTGCCTCCTTCTATGACAATC	0.269													46	121					0	0	0	0	G	40696615	G	G	40696615	3	3	122	1	0	0	0	0	1	0	0	0	9083	913	32	2	3623	2	LRRK2	12	40696615	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	12827289	40696615	93155280	314	21761											
C12orf54	121273	broad.mit.edu	37	chr12	48888677	48888677	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaggccgtatccacaacctGaagacacagctcttcagtca	12	7	9	13	1	3	2	2	1	1	1	4	3	4	3	3	2	2	2	3	2	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:48888677G>A	uc001rrr.2	+	7	396	c.339G>A	c.(337-339)CTG>CTA	p.L113L	C12orf54_uc009zky.1_RNA	NM_152319	NP_689532	Q6X4T0	CL054_HUMAN	hypothetical protein LOC121273	113											0						TCCACAACCTGAAGACACAGC	0.498													45	84					0	0	0	0	A	48888677	A	A	48888677	2	1	122	1	0	0	0	0	0	0	0	1	1705	1277	45	2		2	C12orf54	12	48888677	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8192062	48888677	84963218	315	21762											
OR8S1	341568	broad.mit.edu	37	chr12	48919697	48919697	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaggaaaaccatttcagtaGagggctgcctggctcaggtc	11	8	13	9	0	2	2	2	0	0	2	3	3	2	3	2	4	2	3	2	4	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:48919697G>A	uc010slu.1	+	1	283	c.283G>A	c.(283-285)GAG>AAG	p.E95K		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CATTTCAGTAGAGGGCTGCCT	0.527													21	53					0	0	0	0	A	48919697	A	A	48919697	3	1	122	1	0	0	0	0	1	0	0	0	11300	943	33	2	285	2	OR8S1	12	48919697	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	31020	48919697	84932198	316	21763											
OR8S1	341568	broad.mit.edu	37	chr12	48919765	48919765	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaagcctgccttctctcaggGatggcctatgaccgccatgc	7	9	11	14	1	2	1	1	1	1	0	3	3	2	2	5	2	3	0	5	2	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:48919765G>T	uc010slu.1	+	1	351	c.351G>T	c.(349-351)GGG>GGT	p.G117G		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTCTCTCAGGGATGGCCTATG	0.537													38	67					6.5261e-18	7.02897e-18	1	0	T	48919765	T	T	48919765	2	4	122	1	0	0	0	0	0	0	0	1	11300	1161	41	2		2	OR8S1	12	48919765	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	68	48919765	84932130	317	21764											
SCN8A	6334	broad.mit.edu	37	chr12	52156422	52156422	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taatggaactgagtctagcaGacgtggaggggctttcagtg	10	10	15	6	1	2	2	1	1	1	1	2	4	2	4	0	4	2	2	0	4	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:52156422G>C	uc001ryw.2	+	15	2684	c.2506G>C	c.(2506-2508)GAC>CAC	p.D836H	SCN8A_uc010snl.1_Missense_Mutation_p.D701H|SCN8A_uc001ryy.2_Missense_Mutation_p.D701H	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	836	II.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GAGTCTAGCAGACGTGGAGGG	0.408													47	86					0	0	0	0	C	52156422	C	C	52156422	3	2	122	1	0	0	0	0	1	0	0	0	13989	942	33	2	2560	2	SCN8A	12	52156422	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3236657	52156422	81695473	318	21765											
MAP3K12	7786	broad.mit.edu	37	chr12	53879964	53879964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcggccagcccgcagtacctCatacagctggccctgggcgc	6	5	13	17	3	1	0	1	0	0	0	1	0	1	0	4	3	4	3	4	3	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:53879964C>T	uc001sdm.1	-	5	696	c.598G>A	c.(598-600)GAG>AAG	p.E200K	MAP3K12_uc001sdn.1_Missense_Mutation_p.E233K	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	200	Protein kinase.				histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						CGCAGTACCTCATACAGCTGG	0.597													23	34					0	0	0	0	T	53879964	T	T	53879964	3	4	122	1	0	0	0	0	1	0	0	0	9299	835	29	2	2025	2	MAP3K12	12	53879964	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1723542	53879964	79971931	319	21766											
HOXC13	3229	broad.mit.edu	37	chr12	54338956	54338956	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgaacctctctgagcgccaGgtaaccatctggttccagaa	11	8	9	13	2	2	2	0	1	2	1	4	3	3	2	4	2	3	2	4	2	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:54338956G>C	uc001sei.2	+	2	1024	c.909G>C	c.(907-909)CAG>CAC	p.Q303H	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	303	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CTGAGCGCCAGGTAACCATCT	0.577			T	NUP98	AML								26	39					0	0	0	0	C	54338956	C	C	54338956	3	2	122	1	0	0	0	0	1	0	0	0	7351	991	35	4	915	4	HOXC13	12	54338956	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	458992	54338956	79512939	320	21767											
STAT2	6773	broad.mit.edu	37	chr12	56742395	56742395	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccagaatggtaacttgccagGagggctctctcgctggagga	9	8	14	10	1	1	1	0	0	1	1	3	4	1	4	2	5	2	3	2	5	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:56742395G>T	uc001slc.2	-	19	1720	c.1642C>A	c.(1642-1644)CCT>ACT	p.P548T	STAT2_uc001slb.2_Missense_Mutation_p.P90T|STAT2_uc001sld.2_Missense_Mutation_p.P544T	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	548					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						AACTTGCCAGGAGGGCTCTCT	0.527													35	52					2.42023e-17	2.5934e-17	1	0	T	56742395	T	T	56742395	3	4	122	1	0	0	0	0	1	0	0	0	15331	1174	41	2	937	2	STAT2	12	56742395	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2403439	56742395	77109500	321	21768											
LRP1	4035	broad.mit.edu	37	chr12	57573152	57573152	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tacgcacgtcagatggagatCcgaggtgtggacctggatgc	9	8	15	9	3	1	2	1	0	0	2	2	6	2	4	2	4	2	1	2	4	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:57573152C>T	uc001snd.2	+	29	5245	c.4779C>T	c.(4777-4779)ATC>ATT	p.I1593I		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1593	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGATGGAGATCCGAGGTGTGG	0.567													13	19					0	0	0	0	T	57573152	T	T	57573152	2	4	122	1	0	0	0	0	0	0	0	1	9001	845	30	2		2	LRP1	12	57573152	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	830757	57573152	76278743	322	21769											
SHMT2	6472	broad.mit.edu	37	chr12	57626334	57626334	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagcgcctatgctcgcctCattgactacgcccgcatgag	8	8	9	16	4	1	2	1	2	0	0	2	2	1	2	4	0	3	2	4	0	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:57626334C>G	uc001snf.1	+	6	703	c.693C>G	c.(691-693)CTC>CTG	p.L231L	SHMT2_uc001sng.1_Silent_p.L127L|SHMT2_uc001snh.1_Silent_p.L70L|SHMT2_uc009zpk.1_Silent_p.L221L|SHMT2_uc001sni.1_Silent_p.L210L|SHMT2_uc010srg.1_Silent_p.L240L|SHMT2_uc001snj.1_Silent_p.L135L|SHMT2_uc010srh.1_Silent_p.L210L|SHMT2_uc001snk.1_Silent_p.L135L|SHMT2_uc010sri.1_Silent_p.L210L|SHMT2_uc001snl.2_Silent_p.L135L|SHMT2_uc010srj.1_5'Flank	NM_005412	NP_005403	P34897	GLYM_HUMAN	serine hydroxymethyltransferase 2	231						microtubule cytoskeleton|mitochondrial nucleoid	glycine hydroxymethyltransferase activity|methyltransferase activity			ovary(1)|central_nervous_system(1)	2					Glycine(DB00145)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	ATGCTCGCCTCATTGACTACG	0.632													46	90					0	0	0	0	G	57626334	G	G	57626334	2	3	122	1	0	0	0	0	0	0	0	1	14351	813	29	2		2	SHMT2	12	57626334	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	53182	57626334	76225561	323	21770											
INHBE	83729	broad.mit.edu	37	chr12	57850383	57850383	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggactggatactgcagcccGaggggtaccagctgaattac	10	7	14	10	1	0	1	0	1	0	0	0	4	0	3	2	4	6	3	2	4	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:57850383G>A	uc001snw.2	+	2	1029	c.805G>A	c.(805-807)GAG>AAG	p.E269K		NM_031479	NP_113667	P58166	INHBE_HUMAN	activin beta E precursor	269					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)	3						ACTGCAGCCCGAGGGGTACCA	0.612											OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	48					0	0	0	0	A	57850383	A	A	57850383	3	1	122	1	0	0	0	0	1	0	0	0	7783	1059	37	1	811	1	INHBE	12	57850383	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	224049	57850383	76001512	324	21771											
METTL1	4234	broad.mit.edu	37	chr12	58163393	58163393	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgctagcagggtgggactGatgattcgccacttgtgctt	6	13	13	9	1	1	2	0	2	1	0	2	3	1	3	1	2	3	3	1	2	1	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:58163393G>C	uc010ssd.1	-	4	576	c.528C>G	c.(526-528)ATC>ATG	p.I176M	CYP27B1_uc001spz.1_5'Flank|CYP27B1_uc001sqa.1_5'Flank|METTL1_uc009zqc.2_Missense_Mutation_p.Q115E|FAM119B_uc001sqf.2_5'Flank|FAM119B_uc001sqg.2_5'Flank|FAM119B_uc009zqd.2_5'Flank	NM_005371	NP_005362	Q9UBP6	TRMB_HUMAN	methyltransferase-like protein 1 isoform a	176						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding				0	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			GGGTGGGACTGATGATTCGCC	0.542													45	95					0	0	0	0	C	58163393	C	C	58163393	3	2	122	1	0	0	0	0	1	0	0	0	9546	1299	45	2	314	2	METTL1	12	58163393	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	313010	58163393	75688502	325	21772											
E2F7	144455	broad.mit.edu	37	chr12	77419538	77419538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaagctgggctattgatcCaaggccaggcaagctgaaat	13	7	13	8	0	0	3	0	2	0	1	1	4	1	3	2	3	2	4	2	3	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:77419538C>T	uc001sym.3	-	12	2601	c.2365G>A	c.(2365-2367)GGA>AGA	p.G789R	E2F7_uc009zse.2_Intron	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	789					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						GCTATTGATCCAAGGCCAGGC	0.537													20	32					0	0	0	0	T	77419538	T	T	77419538	3	4	122	1	0	0	0	0	1	0	0	0	4894	603	21	4	378	4	E2F7	12	77419538	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	19256145	77419538	56432357	326	21773											
C12orf50	160419	broad.mit.edu	37	chr12	88381726	88381726	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttagggaatgctttggatGaggactgtccttgttatctt	8	16	12	5	0	1	1	0	1	1	0	2	4	2	4	1	3	1	3	1	3	3	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:88381726G>A	uc001tam.1	-	9	886	c.718C>T	c.(718-720)CAT>TAT	p.H240Y	C12orf50_uc001tan.2_Intron	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	240										skin(2)|ovary(1)	3						TGCTTTGGATGAGGACTGTCC	0.333													24	37					0	0	0	0	A	88381726	A	A	88381726	3	1	122	1	0	0	0	0	1	0	0	0	1701	1290	45	2	546	2	C12orf50	12	88381726	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	10962188	88381726	45470169	327	21774											
FGD6	55785	broad.mit.edu	37	chr12	95603900	95603900	+	Missense_Mutation	SNP	T	A	A																															catcactgttggattccataTtcaattcacttttatttcct																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:95603900T>A	uc001tdp.3	-	2	1384	c.1160A>T	c.(1159-1161)AAT>ATT	p.N387I	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	387					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						GGATTCCATATTCAATTCACT	0.333													30	68					0	0	0	0	A	95603900	A	A	95603900	3	1	122	1	0	0	0	0	1	0	0	0	5869	1493	52	5	3212	5	FGD6	12	95603900	Missense_Mutation	SNP	T	TCGA-CR-6472-01A-11D-1870-08	7222174	95603900	38247995	328	21775	43	2									
FGD6	55785	broad.mit.edu	37	chr12	95603902	95603902	+	Silent	SNP	C	T	T																															tcactgttggattccatattCaattcacttttatttcctag																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:95603902C>T	uc001tdp.3	-	2	1382	c.1158G>A	c.(1156-1158)TTG>TTA	p.L386L	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	386					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						ATTCCATATTCAATTCACTTT	0.333													29	68					0	0	0	0	T	95603902	T	T	95603902	2	4	122	1	0	0	0	0	0	0	0	1	5869	825	29	2		2	FGD6	12	95603902	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2	95603902	38247993	329	21776	43	2									
ARL1	400	broad.mit.edu	37	chr12	101794928	101794928	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgactgcatctgtgtttGaatagtaacatctccagtat	13	14	7	7	0	2	2	0	2	2	0	3	2	2	2	1	0	2	4	1	0	5	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:101794928G>C	uc001tib.2	-	4	397	c.248C>G	c.(247-249)TCA>TGA	p.S83*	ARL1_uc010svn.1_Nonsense_Mutation_p.S37*|ARL1_uc010svo.1_RNA|ARL1_uc001tic.2_Nonsense_Mutation_p.S83*	NM_001177	NP_001168	P40616	ARL1_HUMAN	ADP-ribosylation factor-like 1	83					small GTPase mediated signal transduction	Golgi membrane	enzyme activator activity|GTP binding|GTPase activity|metal ion binding|protein binding			central_nervous_system(1)	1		Lung NSC(355;2.1e-05)|Breast(359;0.00015)|Myeloproliferative disorder(1001;0.163)		GBM - Glioblastoma multiforme(134;1.67e-09)|BRCA - Breast invasive adenocarcinoma(302;0.0125)		ATCTGTGTTTGAATAGTAACA	0.368													28	77					0	0	0	0	C	101794928	C	C	101794928	4	2	122	1	0	0	0	0	0	1	0	0	925	1294	45	2	309	2	ARL1	12	101794928	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	6191026	101794928	32056967	330	21777											
CORO1C	23603	broad.mit.edu	37	chr12	109051145	109051145	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtggtgaagacattgccatCggccaggaagatggctctca	11	8	13	9	1	1	3	1	1	1	2	3	4	1	4	2	4	1	1	2	4	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:109051145C>T	uc001tnj.2	-	6	781	c.685G>A	c.(685-687)GAT>AAT	p.D229N	CORO1C_uc009zva.2_Missense_Mutation_p.D282N|CORO1C_uc010sxf.1_Missense_Mutation_p.D192N	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	229					actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						ACATTGCCATCGGCCAGGAAG	0.547													37	54					0	0	0	0	T	109051145	T	T	109051145	3	4	122	1	0	0	0	0	1	0	0	0	3770	884	31	1	763	1	CORO1C	12	109051145	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	7256217	109051145	24800750	331	21778											
ACACB	32	broad.mit.edu	37	chr12	109675123	109675123	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccaaggtgaaggaaggtgtgGaagtgacggaccataggttc	12	7	16	6	1	0	2	0	2	0	0	1	5	0	5	2	6	0	1	2	6	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:109675123G>C	uc001tob.2	+	34	4719	c.4600G>C	c.(4600-4602)GAA>CAA	p.E1534Q	ACACB_uc001toc.2_Missense_Mutation_p.E1534Q|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.E200Q	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1534					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGAAGGTGTGGAAGTGACGGA	0.532													27	42					0	0	0	0	C	109675123	C	C	109675123	3	2	122	1	0	0	0	0	1	0	0	0	107	1175	41	2	4730	2	ACACB	12	109675123	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	623978	109675123	24176772	332	21779											
UBE3B	89910	broad.mit.edu	37	chr12	109945505	109945505	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcaactcttggccatgctGatgctgttctgtgactgttc	7	14	10	10	0	2	2	0	2	2	0	3	2	2	2	1	1	4	5	1	1	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:109945505G>A	uc001top.2	+	15	2190	c.1587G>A	c.(1585-1587)CTG>CTA	p.L529L	UBE3B_uc001toq.2_Silent_p.L529L|UBE3B_uc001tos.2_5'Flank|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Silent_p.L529L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	529					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						TGGCCATGCTGATGCTGTTCT	0.498													56	82					0	0	0	0	A	109945505	A	A	109945505	2	1	122	1	0	0	0	0	0	0	0	1	16948	1277	45	2		2	UBE3B	12	109945505	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	270382	109945505	23906390	333	21780											
TRPV4	59341	broad.mit.edu	37	chr12	110246198	110246198	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccgggacacgatgtcaaaGaggataggccggttgaagac	12	5	14	10	3	1	3	1	1	0	2	1	6	1	5	3	4	0	1	3	4	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:110246198G>C	uc001tpj.1	-	2	557	c.462C>G	c.(460-462)CTC>CTG	p.L154L	TRPV4_uc001tpg.1_Silent_p.L120L|TRPV4_uc001tph.1_Silent_p.L154L|TRPV4_uc001tpi.1_Silent_p.L154L|TRPV4_uc001tpk.1_Silent_p.L154L|TRPV4_uc001tpl.1_Silent_p.L154L	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	154	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CGATGTCAAAGAGGATAGGCC	0.607													17	56					0	0	0	0	C	110246198	C	C	110246198	2	2	122	1	0	0	0	0	0	0	0	1	16665	929	33	2		2	TRPV4	12	110246198	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	300693	110246198	23605697	334	21781											
DDX54	79039	broad.mit.edu	37	chr12	113612896	113612896	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcggagaacagcaccgtCtggtggcccccggggaggcg	6	4	19	12	4	1	1	0	0	1	1	1	3	1	2	3	7	2	1	3	7	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:113612896C>A	uc001tup.2	-	8	847	c.819G>T	c.(817-819)CAG>CAT	p.Q273H	DDX54_uc001tuq.3_Missense_Mutation_p.Q273H	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	273	Helicase ATP-binding.				estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						ACAGCACCGTCTGGTGGCCCC	0.468											OREG0022139	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	53					1.22384e-17	1.31588e-17	1	0	A	113612896	A	A	113612896	3	1	122	1	0	0	0	0	1	0	0	0	4389	912	32	2	1881	2	DDX54	12	113612896	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	3366698	113612896	20238999	335	21782											
WSB2	55884	broad.mit.edu	37	chr12	118474261	118474261	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaagagacaacactgctttGatggccctctagcttccgaa	12	9	8	12	1	1	2	0	1	1	1	2	4	2	2	2	1	3	2	2	1	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:118474261G>C	uc001twr.2	-	6	813	c.715C>G	c.(715-717)CAA>GAA	p.Q239E	WSB2_uc010sza.1_Missense_Mutation_p.Q14E|WSB2_uc010szb.1_Missense_Mutation_p.Q29E|WSB2_uc009zws.1_Missense_Mutation_p.Q239E	NM_018639	NP_061109	Q9NYS7	WSB2_HUMAN	WD SOCS-box protein 2	239	WD 4.				intracellular signal transduction					ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACACTGCTTTGATGGCCCTCT	0.507													56	87					0	0	0	0	C	118474261	C	C	118474261	3	2	122	1	0	0	0	0	1	0	0	0	17473	1299	45	2	515	2	WSB2	12	118474261	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4861365	118474261	15377634	336	21783											
CCDC64	92558	broad.mit.edu	37	chr12	120518755	120518755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaccgactcagagtcacttCtgaggacaaggagccaaagg	14	5	12	10	1	3	3	2	1	1	2	3	6	3	5	2	3	1	0	2	3	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:120518755C>T	uc001txl.1	+	7	1398	c.1373C>T	c.(1372-1374)TCT>TTT	p.S458F	CCDC64_uc009zwv.1_RNA|CCDC64_uc010sze.1_Missense_Mutation_p.S129F|CCDC64_uc010szf.1_Missense_Mutation_p.S155F	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	458	Potential.				Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGAGTCACTTCTGAGGACAAG	0.498													21	34					0	0	0	0	T	120518755	T	T	120518755	3	4	122	1	0	0	0	0	1	0	0	0	2848	913	32	2	1399	2	CCDC64	12	120518755	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2044494	120518755	13333140	337	21784											
GPR109B	8843	broad.mit.edu	37	chr12	123200745	123200745	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggaaggtatggcagatgctGaagctgatgcacacatttgc	11	9	13	8	1	0	3	0	2	0	1	0	4	0	4	0	3	4	5	0	3	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:123200745G>C	uc001ucy.3	-	1	695	c.540C>G	c.(538-540)TTC>TTG	p.F180L	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	180	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	GGCAGATGCTGAAGCTGATGC	0.522													25	53					0	0	0	0	C	123200745	C	C	123200745	3	2	122	1	0	0	0	0	1	0	0	0	6664	1281	45	2	627	2	GPR109B	12	123200745	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2681990	123200745	10651150	338	21785											
TMEM132B	114795	broad.mit.edu	37	chr12	125834005	125834020	+	Frame_Shift_Del	DEL	GAGTCGAGGGATTGTG	-	-																															ctttcttgtgcagtgacagaGagtcgagggattgtggatag																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:125834005_125834020delGAGTCGAGGGATTGTG	uc001uhe.1	+	2	68_83	c.60_75delGAGTCGAGGGATTGTG	c.(58-75)GAGAGTCGAGGGATTGTGfs	p.E20fs		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	20_25	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CAGTGACAGAGAGTCGAGGGATTGTGGATAGCCTGC	0.472													---	---	---								-	125834020	-	-	125834005	7	5	122	1	0	1	0	1	0	0	0	0	16112	933	33	0	66	0	TMEM132B	12	125834005	Frame_Shift_Del	DEL	GAGTCGAGGGATTGTG	TCGA-CR-6472-01A-11D-1870-08	2633260	125834005	8017890	339	21786											
GPR133	283383	broad.mit.edu	37	chr12	131569129	131569129	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacggctgtgcgctcacgaGaggaaacctcacctactccg	9	6	10	16	4	2	1	2	0	0	1	3	3	3	2	4	2	3	2	4	2	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr12:131569129G>C	uc001uit.3	+	15	2151	c.1592G>C	c.(1591-1593)AGA>ACA	p.R531T	GPR133_uc010tbm.1_Missense_Mutation_p.R563T|GPR133_uc009zyo.2_5'UTR|GPR133_uc001uiv.1_Missense_Mutation_p.R50T	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	531	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GCGCTCACGAGAGGAAACCTC	0.622													20	32					0	0	0	0	C	131569129	C	C	131569129	3	2	122	1	0	0	0	0	1	0	0	0	6681	942	33	2	1650	2	GPR133	12	131569129	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5735124	131569129	2282766	340	21787											
TNFRSF19	55504	broad.mit.edu	37	chr13	24243009	24243009	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acattcattctctcaatccaGaacttgaaagctcaacgtct	13	12	4	12	1	5	2	3	1	2	1	7	2	6	2	1	0	3	1	1	0	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr13:24243009G>A	uc001uov.1	+	9	1082	c.1018G>A	c.(1018-1020)GAA>AAA	p.E340K	TNFRSF19_uc001uot.2_Missense_Mutation_p.E340K|TNFRSF19_uc010tcu.1_Missense_Mutation_p.E208K|TNFRSF19_uc001uow.2_Missense_Mutation_p.E340K	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	340	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TCTCAATCCAGAACTTGAAAG	0.448													46	40					0	0	0	0	A	24243009	A	A	24243009	3	1	122	1	0	0	0	0	1	0	0	0	16358	943	33	2	1048	2	TNFRSF19	13	24243009	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08		24243009	90926869	341	21788											
TSC22D1	8848	broad.mit.edu	37	chr13	45149790	45149790	+	Missense_Mutation	SNP	G	C	C																															ttccgtgtgagattcatccaGatcatcatagctctcagtgt																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr13:45149790G>C	uc001uzn.3	-	1	912	c.421C>G	c.(421-423)CTG>GTG	p.L141V	TSC22D1_uc001uzo.1_Missense_Mutation_p.L141V	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	141					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		GATTCATCCAGATCATCATAG	0.488													26	21					0	0	0	0	C	45149790	C	C	45149790	3	2	122	1	0	0	0	0	1	0	0	0	16674	933	33	2	2941	2	TSC22D1	13	45149790	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	20906781	45149790	70020088	342	21789	44	2									
TSC22D1	8848	broad.mit.edu	37	chr13	45149798	45149798	+	Missense_Mutation	SNP	T	C	C																															gagattcatccagatcatcaTagctctcagtgtcctctgct																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr13:45149798T>C	uc001uzn.3	-	1	904	c.413A>G	c.(412-414)TAT>TGT	p.Y138C	TSC22D1_uc001uzo.1_Missense_Mutation_p.Y138C	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	138					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		CAGATCATCATAGCTCTCAGT	0.473													25	23					0	0	0	0	C	45149798	C	C	45149798	3	2	122	1	0	0	0	0	1	0	0	0	16674	1406	49	5	2949	5	TSC22D1	13	45149798	Missense_Mutation	SNP	T	TCGA-CR-6472-01A-11D-1870-08	8	45149798	70020080	343	21790	44	2									
RAP2A	5911	broad.mit.edu	37	chr13	98086796	98086796	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccctgaccgtgcagttcgtGaccggcaccttcatcgagaa	8	8	11	14	4	1	3	1	2	0	1	3	4	1	3	4	1	1	3	4	1	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr13:98086796G>C	uc001vnd.2	+	1	322	c.72G>C	c.(70-72)GTG>GTC	p.V24V		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	24					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			TGCAGTTCGTGACCGGCACCT	0.542													34	19					0	0	0	0	C	98086796	C	C	98086796	2	2	122	1	0	0	0	0	0	0	0	1	13105	1277	45	2		2	RAP2A	13	98086796	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	52936998	98086796	17083082	344	21791											
MYH7	4625	broad.mit.edu	37	chr14	23901905	23901905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagatgtggggcggggcctCgctcctcttcttgccccggt	3	10	15	13	3	2	1	0	0	2	1	4	2	3	1	4	5	1	1	4	5	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:23901905C>T	uc001wjx.2	-	5	551	c.445G>A	c.(445-447)GAG>AAG	p.E149K		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	149	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GGCGGGGCCTCGCTCCTCTTC	0.597													47	30					0	0	0	0	T	23901905	T	T	23901905	3	4	122	1	0	0	0	0	1	0	0	0	10092	893	31	1	5506	1	MYH7	14	23901905	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08		23901905	83447635	345	21792											
NYNRIN	57523	broad.mit.edu	37	chr14	24886199	24886199	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctttgctgcacctggccttCagggcctcctccactgatgc	4	11	9	17	0	1	1	1	1	0	0	3	1	3	1	6	2	3	2	6	2	0	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:24886199C>T	uc001wpf.3	+	9	5562	c.5244C>T	c.(5242-5244)TTC>TTT	p.F1748F		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1748	Integrase catalytic.				DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						ACCTGGCCTTCAGGGCCTCCT	0.612													12	9					0	0	0	0	T	24886199	T	T	24886199	2	4	122	1	0	0	0	0	0	0	0	1	10850	825	29	2		2	NYNRIN	14	24886199	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	984294	24886199	82463341	346	21793											
POLE2	5427	broad.mit.edu	37	chr14	50117106	50117106	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgcccaatacactgggcaGacataaagaggtaggggagt	14	7	13	7	0	0	2	0	0	0	2	0	3	0	3	1	4	2	2	1	4	6	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:50117106G>C	uc001wwu.2	-	17	1388	c.1374C>G	c.(1372-1374)GTC>GTG	p.V458V	SDCCAG1_uc010anj.1_Intron|POLE2_uc010ann.2_Silent_p.V172V|POLE2_uc001wwv.2_RNA|POLE2_uc010ano.2_Silent_p.V173V	NM_002692	NP_002683	P56282	DPOE2_HUMAN	DNA-directed DNA polymerase epsilon 2	458					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			ovary(1)|skin(1)	2	all_epithelial(31;0.0021)|Breast(41;0.0124)					ACACTGGGCAGACATAAAGAG	0.398													44	20					0	0	0	0	C	50117106	C	C	50117106	2	2	122	1	0	0	0	0	0	0	0	1	12252	929	33	2		2	POLE2	14	50117106	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	25230907	50117106	57232434	347	21794											
DLGAP5	9787	broad.mit.edu	37	chr14	55625316	55625316	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatcaacttcctttggtatCacagaaactgctgtttcagc	10	15	6	10	0	3	1	3	0	0	1	4	1	4	1	1	1	4	3	1	1	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:55625316C>G	uc001xbs.2	-	14	2014	c.1797G>C	c.(1795-1797)GTG>GTC	p.V599V	DLGAP5_uc001xbt.2_Silent_p.V599V	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	599					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						CCTTTGGTATCACAGAAACTG	0.363													30	23					0	0	0	0	G	55625316	G	G	55625316	2	3	122	1	0	0	0	0	0	0	0	1	4585	813	29	2		2	DLGAP5	14	55625316	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	5508210	55625316	51724224	348	21795											
SLC35F4	341880	broad.mit.edu	37	chr14	58048118	58048118	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaagaaagagtttcagcgtCagaccatcttcaccaaaaat	16	10	6	9	1	4	3	3	0	1	3	4	3	4	3	2	0	1	1	2	0	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:58048118C>A	uc001xdb.1	-	4	729	c.729G>T	c.(727-729)CTG>CTT	p.L243L	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Silent_p.L84L	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						GTTTCAGCGTCAGACCATCTT	0.403													3	9					0.004672	0.00470944	1	0	A	58048118	A	A	58048118	2	1	122	1	0	0	0	0	0	0	0	1	14655	813	29	2		2	SLC35F4	14	58048118	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2422802	58048118	49301422	349	21796											
ACTN1	87	broad.mit.edu	37	chr14	69352204	69352204	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgggcagccaggtcactCtcgaaggcctcatgcttctt	6	11	12	12	1	4	0	2	0	2	0	5	1	4	0	2	4	2	2	2	4	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:69352204C>G	uc001xkl.2	-	12	1633	c.1323G>C	c.(1321-1323)GAG>GAC	p.E441D	ACTN1_uc001xkk.2_Missense_Mutation_p.E37D|ACTN1_uc010ttb.1_Missense_Mutation_p.E376D|ACTN1_uc001xkm.2_Missense_Mutation_p.E441D|ACTN1_uc001xkn.2_Missense_Mutation_p.E441D|ACTN1_uc010ttc.1_Missense_Mutation_p.E26D|ACTN1_uc001xko.1_Missense_Mutation_p.E376D|ACTN1_uc010ttd.1_Missense_Mutation_p.E420D	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	441	Spectrin 2.|Interaction with DDN.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CCAGGTCACTCTCGAAGGCCT	0.617													16	11					0	0	0	0	G	69352204	G	G	69352204	3	3	122	1	0	0	0	0	1	0	0	0	204	912	32	2	1465	2	ACTN1	14	69352204	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	11304086	69352204	37997336	350	21797											
SYNJ2BP	55333	broad.mit.edu	37	chr14	70839806	70839806	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tatgggaataccacttgggtCcccttcacctcgatgtccta	8	12	8	13	1	1	0	1	0	0	0	4	2	3	1	5	2	1	0	5	2	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:70839806C>T	uc001xmc.3	-	4	467	c.340G>A	c.(340-342)GAC>AAC	p.D114N	SYNJ2BP_uc010arc.2_RNA	NM_018373	NP_060843	P57105	SYJ2B_HUMAN	synaptojanin 2 binding protein	114	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane					0				all cancers(60;0.00367)|BRCA - Breast invasive adenocarcinoma(234;0.00716)|OV - Ovarian serous cystadenocarcinoma(108;0.0377)		CCACTTGGGTCCCCTTCACCT	0.463													38	21					0	0	0	0	T	70839806	T	T	70839806	3	4	122	1	0	0	0	0	1	0	0	0	15520	855	30	2	101	2	SYNJ2BP	14	70839806	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1487602	70839806	36509734	351	21798											
ADAM21	8747	broad.mit.edu	37	chr14	70925890	70925890	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgtcatatctctgatgtCttttgtgggagagttcaatg	10	16	10	5	0	4	2	2	1	2	1	5	3	4	2	0	1	0	1	0	1	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:70925890C>G	uc001xmd.2	+	1	1674	c.1674C>G	c.(1672-1674)GTC>GTG	p.V558V		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	558	Cys-rich.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TCTCTGATGTCTTTTGTGGGA	0.398													34	20					0	0	0	0	G	70925890	G	G	70925890	2	3	122	1	0	0	0	0	0	0	0	1	243	900	32	2		2	ADAM21	14	70925890	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	86084	70925890	36423650	352	21799											
SPTLC2	9517	broad.mit.edu	37	chr14	77984395	77984395	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttacagtatcaagtatttCtttggtatgagctgctgaca	11	15	8	7	0	2	2	1	2	1	0	2	2	2	2	0	1	3	5	0	1	5	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:77984395C>G	uc001xub.2	-	11	1743	c.1555G>C	c.(1555-1557)GAA>CAA	p.E519Q		NM_004863	NP_004854	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base	519						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			upper_aerodigestive_tract(1)|ovary(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	TCAAGTATTTCTTTGGTATGA	0.393													48	15					0	0	0	0	G	77984395	G	G	77984395	3	3	122	1	0	0	0	0	1	0	0	0	15190	922	32	2	141	2	SPTLC2	14	77984395	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	7058505	77984395	29365145	353	21800											
TRIP11	9321	broad.mit.edu	37	chr14	92488172	92488172	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctttaagatggctgatttCtacctatatatttataatcc	11	17	6	7	0	1	2	0	1	1	1	2	2	2	2	2	2	1	2	2	2	7	10			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:92488172C>G	uc001xzy.2	-	4	1104	c.316G>C	c.(316-318)GAA>CAA	p.E106Q		NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	106	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TGGCTGATTTCTACCTATATA	0.358			T	PDGFRB	AML								20	15					0	0	0	0	G	92488172	G	G	92488172	3	3	122	1	0	0	0	0	1	0	0	0	16622	922	32	2	5695	2	TRIP11	14	92488172	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	14503777	92488172	14861368	354	21801											
SERPINA10	51156	broad.mit.edu	37	chr14	94756786	94756786	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctcctgctcatcttcctCttcctccttgggagcctgca	3	13	8	17	0	3	0	1	0	2	0	7	1	7	1	6	2	3	2	6	2	0	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:94756786C>A	uc001yct.2	-	2	611	c.145G>T	c.(145-147)GAG>TAG	p.E49*	SERPINA10_uc001ycu.3_Nonsense_Mutation_p.E49*	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	49					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TCATCTTCCTCTTCCTCCTTG	0.617													6	5					0.00116845	0.00118541	1	0	A	94756786	A	A	94756786	4	1	122	1	0	0	0	0	0	1	0	0	14152	922	32	2	1205	2	SERPINA10	14	94756786	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2268614	94756786	12592754	355	21802											
ATG2B	55102	broad.mit.edu	37	chr14	96783494	96783494	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctcaccttcacatctgtGaacactgctattaatccatg	12	12	4	13	0	3	1	2	1	1	0	4	1	4	1	3	0	3	1	3	0	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:96783494G>A	uc001yfi.2	-	20	3563	c.3198C>T	c.(3196-3198)TTC>TTT	p.F1066F		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1066										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TCACATCTGTGAACACTGCTA	0.323													34	33					0	0	0	0	A	96783494	A	A	96783494	2	1	122	1	0	0	0	0	0	0	0	1	1096	1281	45	2		2	ATG2B	14	96783494	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2026708	96783494	10566046	356	21803											
PPP1R13B	23368	broad.mit.edu	37	chr14	104206422	104206422	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagcggggagtggggctgtGggctgggcaggggggagctc	4	6	24	7	1	1	0	1	0	0	0	2	2	1	2	0	9	2	4	0	9	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr14:104206422G>A	uc001yof.1	-	12	2614	c.2331C>T	c.(2329-2331)CCC>CCT	p.P777P	PPP1R13B_uc010awv.1_RNA|PPP1R13B_uc001yog.1_Silent_p.P644P	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	777	Pro-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				GTGGGGCTGTGGGCTGGGCAG	0.602													51	32					0	0	0	0	A	104206422	A	A	104206422	2	1	122	1	0	0	0	0	0	0	0	1	12417	1335	47	4		4	PPP1R13B	14	104206422	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	7422928	104206422	3143118	357	21804											
NDN	4692	broad.mit.edu	37	chr15	23932341	23932341	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgcaaagttagggtcgctCagatccttactttgttctga	8	14	10	9	1	2	2	1	1	1	1	4	2	3	2	1	1	2	5	1	1	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:23932341C>G	uc001ywk.2	-	1	110	c.24G>C	c.(22-24)CTG>CTC	p.L8L		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	8					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		TAGGGTCGCTCAGATCCTTAC	0.657									Prader-Willi_syndrome				9	26					0	0	0	0	G	23932341	G	G	23932341	2	3	122	1	0	0	0	0	0	0	0	1	10301	813	29	2		2	NDN	15	23932341	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08		23932341	78599051	358	21805											
UBE3A	7337	broad.mit.edu	37	chr15	25599757	25599757	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cattggtcaccatatgaaaaCctctccgaaaagccttgaac	14	9	6	12	1	2	2	1	2	1	0	3	3	2	2	4	1	3	0	4	1	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:25599757C>T	uc001zaq.2	-	8	2207	c.2207G>A	c.(2206-2208)GGT>GAT	p.G736D	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.G713D|UBE3A_uc001zas.2_Missense_Mutation_p.G733D|UBE3A_uc001zat.2_Missense_Mutation_p.G713D	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	736					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		CATATGAAAACCTCTCCGAAA	0.353													34	64					0	0	0	0	T	25599757	T	T	25599757	3	4	122	1	0	0	0	0	1	0	0	0	16947	507	18	4	436	4	UBE3A	15	25599757	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1667416	25599757	76931635	359	21806											
GABRA5	2558	broad.mit.edu	37	chr15	27188522	27188522	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggtcaattactttaccaaGagaggctgggcctgggatgg	10	9	14	8	1	1	1	1	0	0	1	1	3	1	2	2	5	2	1	2	5	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:27188522G>C	uc001zbd.1	+	11	1377	c.1038G>C	c.(1036-1038)AAG>AAC	p.K346N	GABRA5_uc001zbe.1_5'Flank	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	346	Cytoplasmic (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACTTTACCAAGAGAGGCTGGG	0.522													3	5					0	0	0	0	C	27188522	C	C	27188522	3	2	122	1	0	0	0	0	1	0	0	0	6198	933	33	2	1068	2	GABRA5	15	27188522	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1588765	27188522	75342870	360	21807											
C15orf55	256646	broad.mit.edu	37	chr15	34646777	34646777	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaaggagtatgttgacatCatggaatggctggtggggac	10	10	17	4	0	1	2	1	2	0	0	1	5	1	5	0	6	0	3	0	6	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:34646777C>G	uc001zif.2	+	5	1277	c.1122C>G	c.(1120-1122)ATC>ATG	p.I374M	C15orf55_uc010ucc.1_Missense_Mutation_p.I402M|C15orf55_uc010ucd.1_Missense_Mutation_p.I392M	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	374						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		ATGTTGACATCATGGAATGGC	0.587			T	BRD3|BRD4	lethal midline carcinoma								40	57					0	0	0	0	G	34646777	G	G	34646777	3	3	122	1	0	0	0	0	1	0	0	0	1809	816	29	2	1140	2	C15orf55	15	34646777	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	7458255	34646777	67884615	361	21808											
PLCB2	5330	broad.mit.edu	37	chr15	40591134	40591134	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatgaatttggtcaggtgctCcttcgtcatgtagggtttgg	6	15	14	6	1	2	1	2	1	0	0	4	2	3	1	1	4	1	3	1	4	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:40591134C>G	uc001zld.2	-	9	1016	c.715G>C	c.(715-717)GAG>CAG	p.E239Q	PLCB2_uc010bbo.2_Missense_Mutation_p.E239Q|PLCB2_uc010ucm.1_Missense_Mutation_p.E239Q	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	239					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GTCAGGTGCTCCTTCGTCATG	0.577													26	69					0	0	0	0	G	40591134	G	G	40591134	3	3	122	1	0	0	0	0	1	0	0	0	12083	864	30	2	2938	2	PLCB2	15	40591134	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	5944357	40591134	61940258	362	21809											
CDAN1	146059	broad.mit.edu	37	chr15	43020963	43020963	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtgtcaccagctgctcttgGagaagtgactctgcctggcg	6	11	13	11	1	3	2	1	1	2	1	3	3	3	2	2	2	3	2	2	2	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:43020963G>C	uc001zql.2	-	20	2808	c.2691C>G	c.(2689-2691)CTC>CTG	p.L897L	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Silent_p.L223L	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	897						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		GCTGCTCTTGGAGAAGTGACT	0.607													16	23					0	0	0	0	C	43020963	C	C	43020963	2	2	122	1	0	0	0	0	0	0	0	1	3069	1161	41	2		2	CDAN1	15	43020963	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2429829	43020963	59510429	363	21810											
SPG11	80208	broad.mit.edu	37	chr15	44955770	44955770	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcaccaacagcatcggtaGaacccgccccatggccgcgg	9	4	12	16	4	0	1	0	0	0	1	1	1	0	1	5	4	3	3	5	4	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:44955770G>C	uc001ztx.2	-	1	107	c.76C>G	c.(76-78)CTA>GTA	p.L26V	SPG11_uc010ueh.1_Missense_Mutation_p.L26V|SPG11_uc010uei.1_Missense_Mutation_p.L26V|SPG11_uc001zua.1_Missense_Mutation_p.L26V	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	26	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AGCATCGGTAGAACCCGCCCC	0.721													5	3					0	0	0	0	C	44955770	C	C	44955770	3	2	122	1	0	0	0	0	1	0	0	0	15107	933	33	2	7415	2	SPG11	15	44955770	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1934807	44955770	57575622	364	21811											
LEO1	123169	broad.mit.edu	37	chr15	52242003	52242003	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaatttccatacacgactcAcctcgaatgccccctttata	11	12	4	14	2	1	0	1	0	0	0	3	2	2	0	4	0	2	1	4	0	5	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:52242003A>T	uc002abo.2	-	10	1814	c.1798_splice	c.e10+1	p.E600_splice	LEO1_uc010bfd.2_Splice_Site_p.E540_splice	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,						histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		TACACGACTCACCTCGAATGC	0.453													53	128					0	0	0	0	T	52242003	T	T	52242003	5	4	122	1	0	0	0	0	0	0	1	0	8766	173	6	5	212	5	LEO1	15	52242003	Splice_Site	SNP	A	TCGA-CR-6472-01A-11D-1870-08	7286233	52242003	50289389	365	21812											
RNF111	54778	broad.mit.edu	37	chr15	59373350	59373350	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtacagctgcaccaatccctCagcatcttcctcctacacac	10	9	4	18	0	2	0	1	0	1	0	5	0	5	0	4	0	5	4	4	0	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:59373350C>T	uc002afv.2	+	8	2443	c.2164C>T	c.(2164-2166)CAG>TAG	p.Q722*	RNF111_uc002afs.2_Nonsense_Mutation_p.Q722*|RNF111_uc002aft.2_Nonsense_Mutation_p.Q722*|RNF111_uc002afu.2_Nonsense_Mutation_p.Q721*|RNF111_uc002afw.2_Nonsense_Mutation_p.Q722*|RNF111_uc002afx.2_Nonsense_Mutation_p.Q248*	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	722	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		ACCAATCCCTCAGCATCTTCC	0.502													48	91					0	0	0	0	T	59373350	T	T	59373350	4	4	122	1	0	0	0	0	0	1	0	0	13490	827	29	2	2190	2	RNF111	15	59373350	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	7131347	59373350	43158042	366	21813											
RORA	6095	broad.mit.edu	37	chr15	60795042	60795042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtcaaaggcacggcacattCtgataaacaccacctctaga	15	7	7	12	1	3	2	1	1	2	1	3	2	3	2	2	2	1	2	2	2	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:60795042C>T	uc002agv.2	-	9	1355	c.1199G>A	c.(1198-1200)AGA>AAA	p.R400K	uc002ags.1_Intron|RORA_uc002agt.3_Missense_Mutation_p.R312K|RORA_uc002agw.2_Missense_Mutation_p.R392K|RORA_uc002agx.2_Missense_Mutation_p.R367K	NM_134260	NP_599022	P35398	RORA_HUMAN	RAR-related orphan receptor A isoform b	400	Ligand-binding.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						ACGGCACATTCTGATAAACAC	0.458													104	172					0	0	0	0	T	60795042	T	T	60795042	3	4	122	1	0	0	0	0	1	0	0	0	13593	913	32	2	487	2	RORA	15	60795042	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1421692	60795042	41736350	367	21814											
MYO9A	4649	broad.mit.edu	37	chr15	72154892	72154892	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatcaaagaagaacagtattCacagtatgtagggatgctat	16	11	9	5	0	2	2	2	0	0	2	2	3	2	3	0	1	2	4	0	1	8	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:72154892C>T	uc002atl.3	-	33	6513	c.6040G>A	c.(6040-6042)GAA>AAA	p.E2014K	MYO9A_uc002atk.2_Missense_Mutation_p.E809K	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	2014	Tail.|Phorbol-ester/DAG-type 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GAACAGTATTCACAGTATGTA	0.358													31	41					0	0	0	0	T	72154892	T	T	72154892	3	4	122	1	0	0	0	0	1	0	0	0	10137	835	29	2	1646	2	MYO9A	15	72154892	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	11359850	72154892	30376500	368	21815											
IREB2	3658	broad.mit.edu	37	chr15	78783062	78783062	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atatcacctgcaggaagtatCgctaggaatagtgctgccgc	11	9	11	10	2	1	0	1	0	0	0	2	2	1	2	2	2	3	4	2	2	6	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:78783062C>G	uc002bdr.2	+	18	2445	c.2283C>G	c.(2281-2283)ATC>ATG	p.I761M	IREB2_uc010unb.1_Missense_Mutation_p.I511M	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	761							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		CAGGAAGTATCGCTAGGAATA	0.398													85	151					0	0	0	0	G	78783062	G	G	78783062	3	3	122	1	0	0	0	0	1	0	0	0	7865	874	31	3	2353	3	IREB2	15	78783062	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6628170	78783062	23748330	369	21816											
IL16	3603	broad.mit.edu	37	chr15	81592437	81592437	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caggtgtgtctgagtcccctCccccagggcggcagcccaat	6	7	12	16	1	1	1	0	1	1	0	3	1	3	1	5	3	1	1	5	3	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:81592437C>T	uc002bgh.3	+	14	3146	c.2770C>T	c.(2770-2772)CCC>TCC	p.P924S	IL16_uc010blq.1_Missense_Mutation_p.P878S|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.P966S|IL16_uc002bgg.2_Missense_Mutation_p.P924S|IL16_uc002bgi.1_Missense_Mutation_p.P314S|IL16_uc002bgj.2_Missense_Mutation_p.P418S|IL16_uc002bgk.2_Missense_Mutation_p.P223S|IL16_uc002bgl.1_Missense_Mutation_p.P223S|IL16_uc010unq.1_Missense_Mutation_p.P223S	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	924					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						TGAGTCCCCTCCCCCAGGGCG	0.652													36	42					0	0	0	0	T	81592437	T	T	81592437	3	4	122	1	0	0	0	0	1	0	0	0	7672	855	30	2	2820	2	IL16	15	81592437	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2809375	81592437	20938955	370	21817											
ALPK3	57538	broad.mit.edu	37	chr15	85399943	85399943	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtcagacaggagtgcacaGaagggcatgatgacacaggg	14	4	15	8	0	1	4	1	2	0	2	1	5	1	5	0	3	1	2	0	3	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr15:85399943G>A	uc002ble.2	+	6	2747	c.2580G>A	c.(2578-2580)CAG>CAA	p.Q860Q		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	860					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGAGTGCACAGAAGGGCATGA	0.542													15	32					0	0	0	0	A	85399943	A	A	85399943	2	1	122	1	0	0	0	0	0	0	0	1	546	933	33	2		2	ALPK3	15	85399943	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3807506	85399943	17131449	371	21818											
PDIA2	64714	broad.mit.edu	37	chr16	336596	336596	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaggagatggcccctgcctGggaggcattggctgagaagt	9	7	16	9	0	0	2	0	1	0	2	0	5	0	3	3	5	1	2	3	5	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:336596G>C	uc002cgn.1	+	14	2391	c.1283G>C	c.(1282-1284)TGG>TCG	p.W428S	PDIA2_uc010bqt.1_Missense_Mutation_p.W273S|PDIA2_uc002cgo.1_Missense_Mutation_p.W428S	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	428	Thioredoxin 2.				apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				GCCCCTGCCTGGGAGGCATTG	0.627													17	36					0	0	0	0	C	336596	C	C	336596	3	2	122	1	0	0	0	0	1	0	0	0	11722	1357	47	4	1317	4	PDIA2	16	336596	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08		336596	90018157	372	21819											
FBXL16	146330	broad.mit.edu	37	chr16	745766	745766	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggttgggcagcagctgcGagatggccgcgatggcgtcg	6	6	18	11	5	0	1	0	0	0	1	1	3	0	1	2	4	3	4	2	4	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:745766G>T	uc002cjc.2	-	4	994	c.791C>A	c.(790-792)TCG>TAG	p.S264*	FBXL16_uc002cja.2_5'Flank|FBXL16_uc002cjb.2_Nonsense_Mutation_p.S52*	NM_153350	NP_699181	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	264	LRR 1.										0		Hepatocellular(780;0.0218)				CAGCAGCTGCGAGATGGCCGC	0.692													7	20					0.000673444	0.000686542	1	0	T	745766	T	T	745766	4	4	122	1	0	0	0	0	0	1	0	0	5744	1059	37	3	664	3	FBXL16	16	745766	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	409170	745766	89608987	373	21820											
RPL3L	6123	broad.mit.edu	37	chr16	1996986	1996986	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atagcccttctgcccggcccGagcaatggagcagcccacgc	8	5	11	17	3	1	0	0	0	1	0	1	2	1	1	4	2	5	2	4	2	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:1996986G>A	uc002cnh.2	-	6	849	c.802C>T	c.(802-804)CGG>TGG	p.R268W		NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	268					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						TGCCCGGCCCGAGCAATGGAG	0.672													31	69					0	0	0	0	A	1996986	A	A	1996986	3	1	122	1	0	0	0	0	1	0	0	0	13659	1057	37	1	441	1	RPL3L	16	1996986	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1251220	1996986	88357767	374	21821											
PKD1	5310	broad.mit.edu	37	chr16	2153846	2153846	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgactcggctcccagctCtgagggctgtggtgcccgca	4	9	15	13	2	1	2	0	2	1	0	3	2	2	2	2	4	2	4	2	4	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:2153846C>G	uc002cos.1	-	23	8421	c.8212G>C	c.(8212-8214)GAG>CAG	p.E2738Q	PKD1_uc002cot.1_Missense_Mutation_p.E2738Q|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2738	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GCTCCCAGCTCTGAGGGCTGT	0.567													4	10					0	0	0	0	G	2153846	G	G	2153846	3	3	122	1	0	0	0	0	1	0	0	0	12018	922	32	2	4795	2	PKD1	16	2153846	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	156860	2153846	88200907	375	21822											
DCI	1632	broad.mit.edu	37	chr16	2296965	2296965	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggctgttcactggggggttCttgaatttcatcacagcgac	8	12	12	9	1	4	1	3	1	1	0	4	2	4	1	0	4	1	3	0	4	1	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:2296965C>G	uc002cpr.2	-	3	225	c.189G>C	c.(187-189)AAG>AAC	p.K63N	DCI_uc002cps.2_Missense_Mutation_p.K63N	NM_001919	NP_001910	P42126	ECI1_HUMAN	dodecenoyl-Coenzyme A delta isomerase precursor	63					fatty acid beta-oxidation	mitochondrial matrix	dodecenoyl-CoA delta-isomerase activity				0						CTGGGGGGTTCTTGAATTTCA	0.517													12	25					0	0	0	0	G	2296965	G	G	2296965	3	3	122	1	0	0	0	0	1	0	0	0	4306	912	32	2	739	2	DCI	16	2296965	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	143119	2296965	88057788	376	21823											
ABCA3	21	broad.mit.edu	37	chr16	2334310	2334310	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagtagtgggcggcgacctCggaggaggtgcagtacctcc	7	6	17	11	3	0	0	0	0	0	0	2	3	1	2	3	5	2	4	3	5	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:2334310C>T	uc002cpy.1	-	25	4544	c.3832G>A	c.(3832-3834)GAG>AAG	p.E1278K	ABCA3_uc010bsk.1_Missense_Mutation_p.E1220K	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1278					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				GCGGCGACCTCGGAGGAGGTG	0.622													22	34					0	0	0	0	T	2334310	T	T	2334310	3	4	122	1	0	0	0	0	1	0	0	0	33	893	31	1	1318	1	ABCA3	16	2334310	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	37345	2334310	88020443	377	21824											
PRSS27	83886	broad.mit.edu	37	chr16	2764177	2764177	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtaattggtgaagggcactgGtgcctccagctccaccaggg	8	8	14	11	0	0	1	0	1	0	0	2	1	2	1	4	4	2	3	4	4	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:2764177G>C	uc002crf.2	-	4	788	c.397C>G	c.(397-399)CCA>GCA	p.P133A	PRSS27_uc002cre.2_Missense_Mutation_p.P97A|PRSS27_uc002crg.2_Missense_Mutation_p.P31A|PRSS27_uc010bst.1_Missense_Mutation_p.P31A	NM_031948	NP_114154	Q9BQR3	PRS27_HUMAN	marapsin precursor	133	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						AAGGGCACTGGTGCCTCCAGC	0.647													23	26					0	0	0	0	C	2764177	C	C	2764177	3	2	122	1	0	0	0	0	1	0	0	0	12683	1261	44	4	487	4	PRSS27	16	2764177	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	429867	2764177	87590576	378	21825											
CREBBP	1387	broad.mit.edu	37	chr16	3779048	3779048	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggttgggtcggggcacattCaggctcacgggggccatctg	5	9	17	10	2	3	0	2	0	1	0	4	0	3	0	1	7	0	3	1	7	0	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:3779048C>T	uc002cvv.2	-	31	6204	c.6000G>A	c.(5998-6000)CTG>CTA	p.L2000L	CREBBP_uc002cvw.2_Silent_p.L1962L	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	2000					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GGGGCACATTCAGGCTCACGG	0.692			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				7	4					0	0	0	0	T	3779048	T	T	3779048	2	4	122	1	0	0	0	0	0	0	0	1	3876	813	29	2		2	CREBBP	16	3779048	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1014871	3779048	86575705	379	21826											
LITAF	9516	broad.mit.edu	37	chr16	11643571	11643571	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctgcagggcatccacgcaGaaggggatgaagcagcagcc	11	4	14	12	1	0	2	0	1	0	1	2	3	2	3	3	3	4	5	3	3	2	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:11643571G>C	uc002daz.2	-	4	641	c.408C>G	c.(406-408)TTC>TTG	p.F136L	LITAF_uc002dba.2_3'UTR|LITAF_uc002dbb.2_Missense_Mutation_p.F136L|LITAF_uc002dbc.2_Missense_Mutation_p.F136L|LITAF_uc002dbd.2_Missense_Mutation_p.F136L	NM_004862	NP_004853	Q99732	LITAF_HUMAN	lipopolysaccharide-induced TNF-alpha factor	136					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|lysosomal membrane	signal transducer activity|WW domain binding			liver(1)	1						CATCCACGCAGAAGGGGATGA	0.582													11	13					0	0	0	0	C	11643571	C	C	11643571	3	2	122	1	0	0	0	0	1	0	0	0	8872	933	33	2	81	2	LITAF	16	11643571	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	7864523	11643571	78711182	380	21827											
TXNDC11	51061	broad.mit.edu	37	chr16	11773491	11773491	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgctggaggctgcttatttCtgctctcagtttctggatct	4	17	10	10	1	4	0	1	0	4	0	6	2	4	2	0	3	2	5	0	3	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:11773491C>T	uc010buu.1	-	13	2580	c.2518G>A	c.(2518-2520)GAA>AAA	p.E840K	TXNDC11_uc002dbg.1_Missense_Mutation_p.E813K	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	840	Potential.				cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						CTGCTTATTTCTGCTCTCAGT	0.597													20	39					0	0	0	0	T	11773491	T	T	11773491	3	4	122	1	0	0	0	0	1	0	0	0	16860	922	32	2	443	2	TXNDC11	16	11773491	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	129920	11773491	78581262	381	21828											
MYH11	4629	broad.mit.edu	37	chr16	15917115	15917115	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccctgagttcactcaccttGaagcatgctccggtaggccg	7	9	11	14	2	2	2	2	2	0	0	3	2	3	2	4	2	2	4	4	2	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:15917115G>A	uc002ddy.2	-	3	606	c.499C>T	c.(499-501)CAA>TAA	p.Q167*	MYH11_uc002ddv.2_Nonsense_Mutation_p.Q167*|MYH11_uc002ddw.2_Nonsense_Mutation_p.Q167*|MYH11_uc002ddx.2_Nonsense_Mutation_p.Q167*|MYH11_uc010bvg.2_5'UTR|MYH11_uc002deb.3_Nonsense_Mutation_p.Q167*	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	167	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CACTCACCTTGAAGCATGCTC	0.592			T	CBFB	AML								25	51					0	0	0	0	A	15917115	A	A	15917115	4	1	122	1	0	0	0	0	0	1	0	0	10084	1299	45	2	5635	2	MYH11	16	15917115	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4143624	15917115	74437638	382	21829											
DNAH3	55567	broad.mit.edu	37	chr16	20952835	20952835	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctctgggaagcttggagaGaatgtcttgtgccaactcct	8	12	12	9	0	2	1	0	0	2	1	4	4	3	3	2	2	3	1	2	2	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:20952835G>C	uc010vbe.1	-	59	11542	c.11542C>G	c.(11542-11544)CTC>GTC	p.L3848V	DNAH3_uc010vbd.1_Missense_Mutation_p.L1283V	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3848					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGCTTGGAGAGAATGTCTTGT	0.478													56	151					0	0	0	0	C	20952835	C	C	20952835	3	2	122	1	0	0	0	0	1	0	0	0	4625	942	33	2	823	2	DNAH3	16	20952835	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5035720	20952835	69401918	383	21830											
ARHGAP17	55114	broad.mit.edu	37	chr16	24950913	24950913	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggaagtccataagcttcacaCcaaagctacacagagagaag	17	5	9	10	0	1	2	1	0	0	2	2	4	2	3	2	1	3	2	2	1	5	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:24950913C>G	uc002dnb.2	-	17	1589	c.1496G>C	c.(1495-1497)GGT>GCT	p.G499A	ARHGAP17_uc002dmy.2_5'Flank|ARHGAP17_uc002dmz.2_Missense_Mutation_p.G23A|ARHGAP17_uc002dna.2_Missense_Mutation_p.G226A|ARHGAP17_uc002dnc.2_Intron|ARHGAP17_uc010vcf.1_Intron	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	499					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		AAGCTTCACACCAAAGCTACA	0.537													15	9					0	0	0	0	G	24950913	G	G	24950913	3	3	122	1	0	0	0	0	1	0	0	0	867	507	18	4	1165	4	ARHGAP17	16	24950913	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	3998078	24950913	65403840	384	21831											
HIRIP3	8479	broad.mit.edu	37	chr16	30006744	30006744	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtggctgcggcccgagtGagctaagtacctccgccgca	7	6	14	14	4	0	1	0	1	0	0	1	2	1	1	4	3	3	4	4	3	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:30006744G>T	uc002dve.2	-	2	567	c.106C>A	c.(106-108)CAC>AAC	p.H36N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvg.1_5'Flank|INO80E_uc002dvh.1_5'Flank|INO80E_uc002dvi.1_5'Flank|INO80E_uc002dvj.1_5'Flank|INO80E_uc002dvk.1_5'Flank|HIRIP3_uc002dvf.2_Missense_Mutation_p.H36N	NM_003609	NP_003600	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	36					chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)	1						CGGCCCGAGTGAGCTAAGTAC	0.662													19	52					8.28177e-16	8.8442e-16	1	0	T	30006744	T	T	30006744	3	4	122	1	0	0	0	0	1	0	0	0	7160	1290	45	2	1588	2	HIRIP3	16	30006744	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5055831	30006744	60348009	385	21832											
N4BP1	9683	broad.mit.edu	37	chr16	48595137	48595137	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtttgaaccccagacttCatgtttctgttctattggca	7	16	8	10	0	3	2	1	1	2	1	3	2	3	2	2	2	1	4	2	2	2	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:48595137C>T	uc002efp.2	-	2	1654	c.1417G>A	c.(1417-1419)GAA>AAA	p.E473K		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	473					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				CCCCAGACTTCATGTTTCTGT	0.383													30	58					0	0	0	0	T	48595137	T	T	48595137	3	4	122	1	0	0	0	0	1	0	0	0	10162	835	29	2	1297	2	N4BP1	16	48595137	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	18588393	48595137	41759616	386	21833											
N4BP1	9683	broad.mit.edu	37	chr16	48595296	48595296	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggaatcagttgtaagctCatttgtgctgctataaacac	12	13	9	7	0	2	0	2	0	0	0	2	1	2	1	0	1	4	5	0	1	5	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:48595296C>A	uc002efp.2	-	2	1495	c.1258G>T	c.(1258-1260)GAG>TAG	p.E420*		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	420					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				GTTGTAAGCTCATTTGTGCTG	0.363													27	40					7.41945e-09	7.71378e-09	1	0	A	48595296	A	A	48595296	4	1	122	1	0	0	0	0	0	1	0	0	10162	835	29	2	1456	2	N4BP1	16	48595296	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	159	48595296	41759457	387	21834											
ADCY7	113	broad.mit.edu	37	chr16	50325658	50325658	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catccacaggtgcccttcttCctgttcattgtcttcgtggt	4	16	8	13	1	3	0	1	0	2	0	6	0	5	0	3	2	1	1	3	2	0	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:50325658C>T	uc002egd.1	+	3	655	c.387C>T	c.(385-387)TTC>TTT	p.F129F	ADCY7_uc002egb.1_Silent_p.F129F|ADCY7_uc002egc.1_Silent_p.F129F	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	129	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	TGCCCTTCTTCCTGTTCATTG	0.657													4	19					0	0	0	0	T	50325658	T	T	50325658	2	4	122	1	0	0	0	0	0	0	0	1	299	854	30	2		2	ADCY7	16	50325658	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1730362	50325658	40029095	388	21835											
SALL1	6299	broad.mit.edu	37	chr16	51174620	51174620	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataggggttcatctggatatGagggtatttctctttgtggc	7	16	13	5	0	3	1	1	1	2	0	4	2	3	2	0	5	0	2	0	5	3	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:51174620G>C	uc010vgs.1	-	2	1544	c.1513C>G	c.(1513-1515)CAT>GAT	p.H505D	SALL1_uc010vgr.1_Missense_Mutation_p.H408D|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	505					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ATCTGGATATGAGGGTATTTC	0.512													41	74					0	0	0	0	C	51174620	C	C	51174620	3	2	122	1	0	0	0	0	1	0	0	0	13875	1290	45	2	2469	2	SALL1	16	51174620	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	848962	51174620	39180133	389	21836											
BBS2	583	broad.mit.edu	37	chr16	56536599	56536599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttactttccccatccactGagcagcagattaactgtatg	11	13	6	11	0	0	2	0	1	0	1	2	2	2	2	3	0	4	3	3	0	3	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:56536599G>A	uc002ejd.2	-	8	1160	c.926C>T	c.(925-927)TCA>TTA	p.S309L	BBS2_uc010ccg.2_Missense_Mutation_p.S309L	NM_031885	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein	309					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1						CCCATCCACTGAGCAGCAGAT	0.408									Bardet-Biedl_syndrome				43	86					0	0	0	0	A	56536599	A	A	56536599	3	1	122	1	0	0	0	0	1	0	0	0	1340	1294	45	2	1279	2	BBS2	16	56536599	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	5361979	56536599	33818154	390	21837											
RSPRY1	89970	broad.mit.edu	37	chr16	57238671	57238671	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcccacttcctagggactgGaggtgccgctactaccatgg	8	8	12	13	1	0	0	0	0	0	0	1	2	1	2	4	4	4	1	4	4	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:57238671G>A	uc002elb.2	+	2	379	c.101G>A	c.(100-102)GGA>GAA	p.G34E	RSPRY1_uc002elc.2_Missense_Mutation_p.G34E|RSPRY1_uc002eld.2_Missense_Mutation_p.G34E|RSPRY1_uc002ele.1_Missense_Mutation_p.G34E	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	34						extracellular region	zinc ion binding			ovary(1)	1						CTAGGGACTGGAGGTGCCGCT	0.532													88	131					0	0	0	0	A	57238671	A	A	57238671	3	1	122	1	0	0	0	0	1	0	0	0	13778	1174	41	2	103	2	RSPRY1	16	57238671	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	702072	57238671	33116082	391	21838											
CNGB1	1258	broad.mit.edu	37	chr16	57954370	57954370	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctctgtccgctccttgaaGagcttcaccagctcctggag	6	12	9	14	1	2	2	1	1	1	1	6	3	5	3	4	1	2	3	4	1	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:57954370G>C	uc002emt.2	-	19	1787	c.1722C>G	c.(1720-1722)CTC>CTG	p.L574L	CNGB1_uc010cdh.2_Silent_p.L568L	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	574	IQ-like.|Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GCTCCTTGAAGAGCTTCACCA	0.592													40	40					0	0	0	0	C	57954370	C	C	57954370	2	2	122	1	0	0	0	0	0	0	0	1	3615	929	33	2		2	CNGB1	16	57954370	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	715699	57954370	32400383	392	21839											
CCDC113	29070	broad.mit.edu	37	chr16	58301439	58301439	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggacaaggagatcttgctGagaaaagagctacttgaaaa	16	8	11	6	0	1	4	0	2	1	3	1	7	1	5	0	2	3	2	0	2	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:58301439G>T	uc002ene.2	+	7	919	c.840G>T	c.(838-840)CTG>CTT	p.L280L	CCDC113_uc010vid.1_Silent_p.L226L	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	280	Potential.					protein complex					0						AGATCTTGCTGAGAAAAGAGC	0.383													32	53					1.56442e-22	1.70837e-22	1	0	T	58301439	T	T	58301439	2	4	122	1	0	0	0	0	0	0	0	1	2762	1277	45	2		2	CCDC113	16	58301439	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	347069	58301439	32053314	393	21840											
CMTM2	146225	broad.mit.edu	37	chr16	66620961	66620961	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccgtggtctttgctgtgaGaagtcggcgatccatgaatc	8	11	13	9	3	1	2	0	2	1	1	4	4	2	2	2	2	2	1	2	2	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:66620961G>C	uc002ept.2	+	3	666	c.506G>C	c.(505-507)AGA>ACA	p.R169T	CMTM2_uc010cdu.2_Missense_Mutation_p.R116T	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	chemokine-like factor superfamily 2	169	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		TTTGCTGTGAGAAGTCGGCGA	0.517													37	85					0	0	0	0	C	66620961	C	C	66620961	3	2	122	1	0	0	0	0	1	0	0	0	3598	942	33	2	516	2	CMTM2	16	66620961	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8319522	66620961	23733792	394	21841											
CES8	283848	broad.mit.edu	37	chr16	67042973	67042973	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaagagtgggcatgaagctCaaggagaagaagatggcttt	15	7	14	5	0	1	5	1	1	0	4	1	6	1	5	0	3	1	3	0	3	5	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:67042973C>G	uc002eqv.2	+	12	1447	c.1404C>G	c.(1402-1404)CTC>CTG	p.L468L	CES8_uc010vix.1_3'UTR|CES8_uc002eqw.2_3'UTR|CES8_uc002eqy.2_Silent_p.L440L|CES8_uc002eqx.2_Silent_p.L344L|CES8_uc010viy.1_3'UTR|CES8_uc010viz.1_Silent_p.L440L|CES8_uc002eqz.2_RNA	NM_173815	NP_776176	Q5XG92	EST4A_HUMAN	carboxylesterase 8 (putative)	538						extracellular region	carboxylesterase activity				0						GCATGAAGCTCAAGGAGAAGA	0.493													64	132					0	0	0	0	G	67042973	G	G	67042973	2	3	122	1	0	0	0	0	0	0	0	1	3288	813	29	2		2	CES8	16	67042973	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	422012	67042973	23311780	395	21842											
TSNAXIP1	55815	broad.mit.edu	37	chr16	67861873	67861873	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acatcaggcgtgtgggacctCgagagccagagcctgcaagc	10	5	14	12	2	1	2	1	0	0	2	2	4	1	3	3	2	4	1	3	2	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:67861873C>G	uc002euj.2	+	16	2348	c.1954C>G	c.(1954-1956)CGA>GGA	p.R652G	TSNAXIP1_uc002euf.3_3'UTR|TSNAXIP1_uc010vka.1_Missense_Mutation_p.R706G|TSNAXIP1_uc010vkb.1_Missense_Mutation_p.R637G|TSNAXIP1_uc002eug.3_Missense_Mutation_p.R360G|TSNAXIP1_uc002euh.3_Missense_Mutation_p.R360G|TSNAXIP1_uc002eui.3_Missense_Mutation_p.R360G|TSNAXIP1_uc002euk.2_Missense_Mutation_p.R385G	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	652					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		TGTGGGACCTCGAGAGCCAGA	0.537													36	74					0	0	0	0	G	67861873	G	G	67861873	3	3	122	1	0	0	0	0	1	0	0	0	16699	876	31	3	2008	3	TSNAXIP1	16	67861873	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	818900	67861873	22492880	396	21843											
LCAT	3931	broad.mit.edu	37	chr16	67974294	67974294	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcaggccacgccatgcgaGagggaaacatccagggggag	11	3	15	12	2	1	1	1	0	0	1	2	4	2	3	4	4	2	0	4	4	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:67974294G>C	uc002euy.1	-	6	847	c.836C>G	c.(835-837)TCT>TGT	p.S279C		NM_000229	NP_000220	P04180	LCAT_HUMAN	lecithin-cholesterol acyltransferase precursor	279					cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|reverse cholesterol transport|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein A-I binding|phosphatidylcholine-sterol O-acyltransferase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00418)|Epithelial(162;0.0183)|all cancers(182;0.12)		CGCCATGCGAGAGGGAAACAT	0.552													34	76					0	0	0	0	C	67974294	C	C	67974294	3	2	122	1	0	0	0	0	1	0	0	0	8698	942	33	2	490	2	LCAT	16	67974294	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	112421	67974294	22380459	397	21844											
SLC12A4	6560	broad.mit.edu	37	chr16	67985730	67985730	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gggagggaggacccaccctgGagcacaccagcagctgcccc	9	2	14	16	0	0	0	0	0	0	0	0	4	0	4	5	4	4	3	5	4	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:67985730G>C	uc002euz.2	-	8	1269	c.1128C>G	c.(1126-1128)CTC>CTG	p.L376L	SLC12A4_uc010ceu.2_Silent_p.L370L|SLC12A4_uc010vkh.1_Silent_p.L345L|SLC12A4_uc010vki.1_Silent_p.L376L|SLC12A4_uc010vkj.1_Silent_p.L378L|SLC12A4_uc002eva.2_Silent_p.L376L|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	376	Helical; (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	ACCCACCCTGGAGCACACCAG	0.632													8	14					0	0	0	0	C	67985730	C	C	67985730	2	2	122	1	0	0	0	0	0	0	0	1	14450	1161	41	2		2	SLC12A4	16	67985730	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	11436	67985730	22369023	398	21845											
NFATC3	4775	broad.mit.edu	37	chr16	68217146	68217146	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgctttccatccttaggctCacattgtccttgaagttcct	6	17	6	12	0	1	1	1	1	0	0	5	1	5	1	4	1	1	3	4	1	2	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:68217146C>G	uc002evo.1	+	8	2185	c.1975C>G	c.(1975-1977)CAC>GAC	p.H659D	NFATC3_uc010vkl.1_Missense_Mutation_p.H180D|NFATC3_uc010vkm.1_Missense_Mutation_p.H180D|NFATC3_uc010vkn.1_Missense_Mutation_p.H180D|NFATC3_uc010vko.1_Missense_Mutation_p.H180D|NFATC3_uc010vkp.1_Missense_Mutation_p.H180D|NFATC3_uc010vkq.1_Missense_Mutation_p.H180D|NFATC3_uc002evl.2_Missense_Mutation_p.H180D|NFATC3_uc002evk.2_Missense_Mutation_p.H659D|NFATC3_uc002evm.1_Missense_Mutation_p.H659D|NFATC3_uc002evn.1_Missense_Mutation_p.H659D|NFATC3_uc010vkr.1_Missense_Mutation_p.H180D|NFATC3_uc010vks.1_Missense_Mutation_p.H180D|NFATC3_uc010vkt.1_Missense_Mutation_p.H180D|NFATC3_uc010vku.1_Missense_Mutation_p.H180D|NFATC3_uc010vkv.1_Missense_Mutation_p.H180D|NFATC3_uc010vkw.1_Missense_Mutation_p.H180D|NFATC3_uc010vkx.1_Missense_Mutation_p.H180D|NFATC3_uc010vky.1_Missense_Mutation_p.H180D|NFATC3_uc010vkz.1_Missense_Mutation_p.H180D|NFATC3_uc010vla.1_Missense_Mutation_p.H180D|NFATC3_uc010vlb.1_Missense_Mutation_p.H180D|NFATC3_uc010vlc.1_Missense_Mutation_p.H180D	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	659					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TCCTTAGGCTCACATTGTCCT	0.418													44	95					0	0	0	0	G	68217146	G	G	68217146	3	3	122	1	0	0	0	0	1	0	0	0	10418	826	29	2	2005	2	NFATC3	16	68217146	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	231416	68217146	22137607	399	21846											
ATP2C2	9914	broad.mit.edu	37	chr16	84444203	84444203	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcgtggtcactgtcgccttCatccaggtgagtatttcctg	5	14	11	11	2	2	1	2	1	0	0	6	1	4	1	3	2	0	1	3	2	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:84444203C>T	uc002fhx.2	+	5	536	c.447C>T	c.(445-447)TTC>TTT	p.F149F	ATP2C2_uc010chj.2_Silent_p.F149F|ATP2C2_uc002fhy.2_Silent_p.F166F|ATP2C2_uc002fhz.2_Missense_Mutation_p.S19L	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	149	Helical; Name=2; (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						CTGTCGCCTTCATCCAGGTGA	0.582													46	38					0	0	0	0	T	84444203	T	T	84444203	2	4	122	1	0	0	0	0	0	0	0	1	1146	825	29	2		2	ATP2C2	16	84444203	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	16227057	84444203	5910550	400	21847											
FBXO31	79791	broad.mit.edu	37	chr16	87369778	87369778	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactcgtactgactggtgtaGatgaacttcatcaggatgag	11	11	11	8	1	2	4	2	3	0	1	3	5	2	5	0	2	2	2	0	2	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:87369778G>C	uc002fjw.2	-	6	869	c.825C>G	c.(823-825)ATC>ATG	p.I275M	FBXO31_uc010vot.1_Missense_Mutation_p.I103M|FBXO31_uc002fjv.2_Missense_Mutation_p.I167M	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	275					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		GACTGGTGTAGATGAACTTCA	0.617													12	17					0	0	0	0	C	87369778	C	C	87369778	3	2	122	1	0	0	0	0	1	0	0	0	5773	932	33	2	810	2	FBXO31	16	87369778	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2925575	87369778	2984975	401	21848											
CBFA2T3	863	broad.mit.edu	37	chr16	88947816	88947816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcccagtggttgagctcctCgcggtcggcctcctggcacc	3	8	13	17	4	0	1	0	1	0	0	4	1	2	1	5	4	1	3	5	4	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr16:88947816C>T	uc002fmm.1	-	9	1471	c.1285G>A	c.(1285-1287)GAG>AAG	p.E429K	CBFA2T3_uc002fml.1_Missense_Mutation_p.E343K|CBFA2T3_uc010cif.1_Missense_Mutation_p.E368K|CBFA2T3_uc002fmk.1_5'Flank	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	429	Mediates localization to the nucleus (By similarity).|Mediates interaction with PDE7A (in isoform 2).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		TTGAGCTCCTCGCGGTCGGCC	0.587			T	RUNX1	AML								6	3					0	0	0	0	T	88947816	T	T	88947816	3	4	122	1	0	0	0	0	1	0	0	0	2710	893	31	1	692	1	CBFA2T3	16	88947816	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1578038	88947816	1406937	402	21849											
VPS53	55275	broad.mit.edu	37	chr17	463774	463775	+	Missense_Mutation	DNP	GA	AT	AT																															gagccctccttttccttgagGaggctgctgatagtcagtcc																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:463774_463775GA>AT	uc002frn.2	-	15	1742_1743	c.1595_1596TC>AT	c.(1594-1596)CTC>CAT	p.L532H	VPS53_uc002frk.2_Missense_Mutation_p.L51H|VPS53_uc010cjo.1_Missense_Mutation_p.L532H|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Missense_Mutation_p.L503H|VPS53_uc002fro.2_Missense_Mutation_p.L334H|VPS53_uc010cjp.1_Missense_Mutation_p.L255H	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	532					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		TTTCCTTGAGGAGGCTGCTGAT	0.495													3	35					0	0	0	0	AT	463775	AT	AT	463774	3	1	122	1	0	0	0	0	1	0	0	0	17283	1161	41	2	949	2	VPS53	17	463774	Missense_Mutation	DNP	GA	TCGA-CR-6472-01A-11D-1870-08		463774	80731436	403	21850											
GLOD4	51031	broad.mit.edu	37	chr17	685477	685477	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactttgaatacgaagtgcaGagctctgcgagcagccatga	12	8	11	10	2	1	3	0	2	1	1	1	5	1	3	1	0	6	3	1	0	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:685477G>A	uc002frv.2	-	1	95	c.19C>T	c.(19-21)CTG>TTG	p.L7L	GLOD4_uc002fru.2_Silent_p.L7L|GLOD4_uc010vqc.1_5'UTR|RNMTL1_uc002frw.2_5'Flank	NM_016080	NP_057164	Q9HC38	GLOD4_HUMAN	glyoxalase domain containing 4	7						mitochondrion					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		ACGAAGTGCAGAGCTCTGCGA	0.667													8	8					0	0	0	0	A	685477	A	A	685477	2	1	122	1	0	0	0	0	0	0	0	1	6487	933	33	2		2	GLOD4	17	685477	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	221703	685477	80509733	404	21851											
RNMTL1	55178	broad.mit.edu	37	chr17	685930	685930	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcccggggacaggaggctGaggtgatgtggttcttgagc	7	10	17	7	1	1	3	0	3	1	0	2	5	2	5	1	6	1	2	1	6	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:685930G>T	uc002frw.2	+	1	418	c.312G>T	c.(310-312)CTG>CTT	p.L104L	GLOD4_uc002fru.2_5'Flank|GLOD4_uc010vqc.1_5'Flank|GLOD4_uc002frv.2_5'Flank	NM_018146	NP_060616	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	104					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		ACAGGAGGCTGAGGTGATGTG	0.572													6	6					0.00116845	0.00118541	1	0	T	685930	T	T	685930	2	4	122	1	0	0	0	0	0	0	0	1	13572	1277	45	2		2	RNMTL1	17	685930	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	453	685930	80509280	405	21852											
ITGAE	3682	broad.mit.edu	37	chr17	3658507	3658507	+	Frame_Shift_Del	DEL	C	-	-																															gcgtgtgtcgtagagcaacgCccctccggaccagtcaaagg																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:3658507delC	uc002fwo.3	-	12	1387	c.1288delG	c.(1288-1290)GCGfs	p.A430fs		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	430	FG-GAP 3.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		TAGAGCAACGCCCCTCCGGAC	0.716													---	---	---								-	3658507	-	-	3658507	7	5	122	1	0	1	0	1	0	0	0	0	7924	739	26	0	2331	0	ITGAE	17	3658507	Frame_Shift_Del	DEL	C	TCGA-CR-6472-01A-11D-1870-08	2972577	3658507	77536703	406	21853											
MED11	400569	broad.mit.edu	37	chr17	4636382	4636382	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatgagggctccagctactCttcgaggaaggactgtcaga	10	8	12	11	1	2	2	1	1	1	1	4	5	3	4	2	3	2	2	2	3	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:4636382C>G	uc002fyp.2	+	3	316	c.254C>G	c.(253-255)TCT>TGT	p.S85C		NM_001001683	NP_001001683	Q9P086	MED11_HUMAN	mediator complex subunit 11	85					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	protein binding				0						TCCAGCTACTCTTCGAGGAAG	0.552													35	19					0	0	0	0	G	4636382	G	G	4636382	3	3	122	1	0	0	0	0	1	0	0	0	9480	913	32	2	264	2	MED11	17	4636382	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	977875	4636382	76558828	407	21854											
EIF4A1	1973	broad.mit.edu	37	chr17	7481674	7481674	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttccagaatcggtcgaggtgGacggtttggccgtaaaggtg	8	10	16	7	4	0	1	0	0	0	1	3	3	1	2	2	6	0	2	2	6	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:7481674G>C	uc002gho.1	+	19	2416	c.1091G>C	c.(1090-1092)GGA>GCA	p.G364A	EIF4A1_uc002ghr.1_Missense_Mutation_p.W343C|EIF4A1_uc002ghq.1_Missense_Mutation_p.W337C|EIF4A1_uc002ghp.1_Missense_Mutation_p.G364A|CD68_uc002ghv.2_5'Flank|CD68_uc002ghu.2_5'Flank	NM_001416	NP_001407	P60842	IF4A1_HUMAN	eukaryotic translation initiation factor 4A	364	Helicase C-terminal.				nuclear-transcribed mRNA poly(A) tail shortening	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA cap binding|translation initiation factor activity			ovary(1)	1						GGTCGAGGTGGACGGTTTGGC	0.507													4	102					0	0	0	0	C	7481674	C	C	7481674	3	2	122	1	0	0	0	0	1	0	0	0	5048	1174	41	2	1133	2	EIF4A1	17	7481674	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2845292	7481674	73713536	408	21855											
MYH10	4628	broad.mit.edu	37	chr17	8379172	8379172	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacatcactggtcttactttCtgtgtcatcgtcggagagct	7	14	10	10	2	4	1	2	0	2	1	6	3	4	1	0	2	2	1	0	2	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:8379172C>G	uc002gll.2	-	41	5977	c.5881G>C	c.(5881-5883)GAA>CAA	p.E1961Q	MYH10_uc002glm.2_Missense_Mutation_p.E1992Q|MYH10_uc010cnx.2_Missense_Mutation_p.E1970Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1961	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GTCTTACTTTCTGTGTCATCG	0.582													88	61					0	0	0	0	G	8379172	G	G	8379172	3	3	122	1	0	0	0	0	1	0	0	0	10083	922	32	2	53	2	MYH10	17	8379172	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	897498	8379172	72816038	409	21856											
MYH10	4628	broad.mit.edu	37	chr17	8393817	8393817	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctcctccagctgggtcctCatttcctccacctgctgctc	4	12	7	18	0	1	0	1	0	0	0	7	0	6	0	6	1	4	4	6	1	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:8393817C>G	uc002gll.2	-	33	4728	c.4632G>C	c.(4630-4632)ATG>ATC	p.M1544I	MYH10_uc002glm.2_Missense_Mutation_p.M1575I|MYH10_uc010cnx.2_Missense_Mutation_p.M1553I	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1544	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GCTGGGTCCTCATTTCCTCCA	0.557													36	32					0	0	0	0	G	8393817	G	G	8393817	3	3	122	1	0	0	0	0	1	0	0	0	10083	826	29	2	1334	2	MYH10	17	8393817	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	14645	8393817	72801393	410	21857											
FLOT2	2319	broad.mit.edu	37	chr17	27208935	27208935	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acgcaggatctcctgtgcctCcacggcaatctgtttcttgc	6	12	9	14	2	3	0	0	0	3	0	5	1	4	1	3	2	2	3	3	2	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:27208935C>G	uc002hdc.2	-	8	934	c.811G>C	c.(811-813)GAG>CAG	p.E271Q		NM_004475	NP_004466	Q14254	FLOT2_HUMAN	flotillin 2	271					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction					0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			TCCTGTGCCTCCACGGCAATC	0.612													21	43					0	0	0	0	G	27208935	G	G	27208935	3	3	122	1	0	0	0	0	1	0	0	0	5969	864	30	2	491	2	FLOT2	17	27208935	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	18815118	27208935	53986275	411	21858											
EFCAB5	374786	broad.mit.edu	37	chr17	28361326	28361326	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctttgccactctgcagatGaatttcgggaggtcataaaa	12	11	9	9	1	2	2	1	1	1	1	3	3	2	3	2	2	2	1	2	2	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:28361326G>T	uc002het.2	+	8	1315	c.1123G>T	c.(1123-1125)GAA>TAA	p.E375*	EFCAB5_uc010wbi.1_Nonsense_Mutation_p.E118*|EFCAB5_uc010wbj.1_Nonsense_Mutation_p.E319*|EFCAB5_uc010wbk.1_Nonsense_Mutation_p.E32*|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Nonsense_Mutation_p.E254*|EFCAB5_uc010csf.2_Nonsense_Mutation_p.E254*	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	375							calcium ion binding			ovary(1)|skin(1)	2						CTCTGCAGATGAATTTCGGGA	0.413													12	38					3.07112e-06	3.16159e-06	1	0	T	28361326	T	T	28361326	4	4	122	1	0	0	0	0	0	1	0	0	4960	1291	45	2	1153	2	EFCAB5	17	28361326	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1152391	28361326	52833884	412	21859											
ATAD5	79915	broad.mit.edu	37	chr17	29185216	29185216	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaatttactgaagaagtaaGaaatcttttgcttgaggaaa	16	12	10	3	0	1	4	0	2	1	2	1	6	1	6	0	2	2	2	0	2	7	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:29185216G>C	uc002hfs.1	+	9	3177	c.2831G>C	c.(2830-2832)AGA>ACA	p.R944T	ATAD5_uc002hft.1_Missense_Mutation_p.R841T	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	944					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GAAGAAGTAAGAAATCTTTTG	0.303													24	34					0	0	0	0	C	29185216	C	C	29185216	3	2	122	1	0	0	0	0	1	0	0	0	1078	942	33	2	2865	2	ATAD5	17	29185216	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	823890	29185216	52009994	413	21860											
CACNB1	782	broad.mit.edu	37	chr17	37340341	37340341	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtttgctggggttgttgaGaactgagcgcttagccaggg	6	12	17	6	1	0	2	0	2	0	1	0	3	0	2	1	3	4	5	1	3	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:37340341G>C	uc002hrm.1	-	10	994	c.841C>G	c.(841-843)CTC>GTC	p.L281V	CACNB1_uc002hrl.1_Missense_Mutation_p.L53V|CACNB1_uc002hrn.2_Missense_Mutation_p.L281V|CACNB1_uc002hro.2_Missense_Mutation_p.L326V	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	281					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	GGGTTGTTGAGAACTGAGCGC	0.582													22	36					0	0	0	0	C	37340341	C	C	37340341	3	2	122	1	0	0	0	0	1	0	0	0	2564	942	33	2	1080	2	CACNB1	17	37340341	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	8155125	37340341	43854869	414	21861											
RAPGEFL1	51195	broad.mit.edu	37	chr17	38347604	38347604	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgtgttccacggggagcgcGgccgccgggagacggccaac	7	3	17	14	7	0	1	0	0	0	1	1	3	1	2	4	5	2	1	4	5	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:38347604G>A	uc010cwu.1	+	9	1244	c.754G>A	c.(754-756)GGC>AGC	p.G252S	RAPGEFL1_uc010wfd.1_Missense_Mutation_p.G188S	NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor	458	Ras-GEF.				G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CGGGGAGCGCGGCCGCCGGGA	0.711													9	9					0	0	0	0	A	38347604	A	A	38347604	3	1	122	1	0	0	0	0	1	0	0	0	13114	1116	39	1	780	1	RAPGEFL1	17	38347604	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1007263	38347604	42847606	415	21862											
KRT38	8687	broad.mit.edu	37	chr17	39595601	39595601	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctggcgcagggagcgctCactctccagcctttcatcac	7	8	10	16	2	4	0	3	0	1	0	5	1	4	1	2	2	3	3	2	2	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:39595601C>T	uc002hwq.1	-	3	1009	c.586G>A	c.(586-588)GAG>AAG	p.E196K		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	196	Rod.|Coil 1B.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				AGGGAGCGCTCACTCTCCAGC	0.622													22	46					0	0	0	0	T	39595601	T	T	39595601	3	4	122	1	0	0	0	0	1	0	0	0	8514	835	29	2	804	2	KRT38	17	39595601	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1247997	39595601	41599609	416	21863											
KRT17	3872	broad.mit.edu	37	chr17	39780615	39780615	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctacccccgagggtgctGcccaggccgccagcagatcc	6	5	12	18	2	0	1	0	0	0	1	1	2	1	1	6	2	5	3	6	2	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:39780615G>A	uc002hxh.2	-	1	268	c.147C>T	c.(145-147)GGC>GGT	p.G49G	JUP_uc010wfs.1_Intron|KRT17_uc010wft.1_Silent_p.G49G	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	49	Head.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				CGAGGGTGCTGCCCAGGCCGC	0.701									Steatocystoma_Multiplex				12	18					0	0	0	0	A	39780615	A	A	39780615	2	1	122	1	0	0	0	0	0	0	0	1	8493	1306	46	4		4	KRT17	17	39780615	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	185014	39780615	41414595	417	21864											
FAM134C	162427	broad.mit.edu	37	chr17	40733894	40733894	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactggtccagaagttcaaaGtcatccccctcagcatcagt	11	9	8	13	0	4	1	4	0	0	1	6	2	6	1	3	1	1	2	3	1	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:40733894G>C	uc002ial.2	-	9	1441	c.1338C>G	c.(1336-1338)GAC>GAG	p.D446E	FAM134C_uc010wgq.1_Missense_Mutation_p.D246E|FAM134C_uc002iam.1_Missense_Mutation_p.D246E|FAM134C_uc010cyk.1_Missense_Mutation_p.D349E	NM_178126	NP_835227	Q86VR2	F134C_HUMAN	hypothetical protein LOC162427	446						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		GAAGTTCAAAGTCATCCCCCT	0.587													22	32					0	0	0	0	C	40733894	C	C	40733894	3	2	122	1	0	0	0	0	1	0	0	0	5475	1020	36	4	66	4	FAM134C	17	40733894	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	953279	40733894	40461316	418	21865											
FAM134C	162427	broad.mit.edu	37	chr17	40734073	40734073	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggttggatcctacaggaaGagcaccaagcaggagctccg	12	5	14	10	1	0	1	0	0	0	1	2	5	2	4	3	4	4	4	3	4	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:40734073G>A	uc002ial.2	-	9	1262	c.1159C>T	c.(1159-1161)CTT>TTT	p.L387F	FAM134C_uc010wgq.1_Missense_Mutation_p.L187F|FAM134C_uc002iam.1_Missense_Mutation_p.L187F|FAM134C_uc010cyk.1_Missense_Mutation_p.L290F	NM_178126	NP_835227	Q86VR2	F134C_HUMAN	hypothetical protein LOC162427	387						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		CCTACAGGAAGAGCACCAAGC	0.657													35	55					0	0	0	0	A	40734073	A	A	40734073	3	1	122	1	0	0	0	0	1	0	0	0	5475	942	33	2	245	2	FAM134C	17	40734073	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	179	40734073	40461137	419	21866											
NAGS	162417	broad.mit.edu	37	chr17	42084746	42084746	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacgggtgcgcagcctggaCaagctggaccagggccgtct	7	6	15	13	3	1	0	0	0	1	0	1	2	1	2	3	4	4	2	3	4	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:42084746C>G	uc002ies.2	+	5	1152	c.1152C>G	c.(1150-1152)GAC>GAG	p.D384E	PYY_uc002ieq.2_5'Flank|NAGS_uc010czn.2_Missense_Mutation_p.D384E|NAGS_uc002iet.2_Missense_Mutation_p.D8E	NM_153006	NP_694551	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	384	N-acetyltransferase.				arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity				0		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	GCAGCCTGGACAAGCTGGACC	0.662											OREG0024449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	32					0	0	0	0	G	42084746	G	G	42084746	3	3	122	1	0	0	0	0	1	0	0	0	10198	477	17	4	1170	4	NAGS	17	42084746	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1350673	42084746	39110464	420	21867											
SLC4A1	6521	broad.mit.edu	37	chr17	42338013	42338013	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaggctcacccttggtgaaGactctacgcagctctaggag	9	8	13	11	1	3	2	1	1	2	1	3	4	3	4	1	4	2	3	1	4	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:42338013G>C	uc002igf.3	-	5	488	c.339C>G	c.(337-339)GTC>GTG	p.V113V	SLC4A1_uc002igg.3_Silent_p.V113V	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	113	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		CCTTGGTGAAGACTCTACGCA	0.642													23	28					0	0	0	0	C	42338013	C	C	42338013	2	2	122	1	0	0	0	0	0	0	0	1	14714	929	33	2		2	SLC4A1	17	42338013	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	253267	42338013	38857197	421	21868											
HEXIM2	124790	broad.mit.edu	37	chr17	43246753	43246753	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccctacaacaccacccagttCctgatgaatgacagggaccc	12	6	7	16	0	0	3	0	3	0	0	1	4	1	4	5	1	2	1	5	1	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:43246753C>A	uc002iih.1	+	4	677	c.438C>A	c.(436-438)TTC>TTA	p.F146L	HEXIM2_uc010daf.1_Missense_Mutation_p.F168L|HEXIM2_uc002iii.1_Missense_Mutation_p.F146L|HEXIM2_uc002iij.1_Missense_Mutation_p.F146L|uc002iik.1_RNA	NM_144608	NP_653209	Q96MH2	HEXI2_HUMAN	hexamthylene bis-acetamide inducible 2	146					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding				0						CCACCCAGTTCCTGATGAATG	0.632													18	29					2.39187e-15	2.54567e-15	1	0	A	43246753	A	A	43246753	3	1	122	1	0	0	0	0	1	0	0	0	7116	854	30	2	444	2	HEXIM2	17	43246753	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	908740	43246753	37948457	422	21869											
KIAA1267	284058	broad.mit.edu	37	chr17	44248690	44248690	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaatctaaagcactgaaaaGaatggaagacaggggagact	19	5	12	5	0	1	5	0	1	1	4	1	7	1	6	0	3	1	1	0	3	7	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:44248690G>C	uc002ikb.2	-	1	905	c.820C>G	c.(820-822)CTT>GTT	p.L274V	KIAA1267_uc002ikc.2_Missense_Mutation_p.L274V|KIAA1267_uc002ikd.2_Missense_Mutation_p.L274V|KIAA1267_uc010dav.2_Missense_Mutation_p.L274V	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	274						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				GCACTGAAAAGAATGGAAGAC	0.483													20	76					0	0	0	0	C	44248690	C	C	44248690	3	2	122	1	0	0	0	0	1	0	0	0	8258	942	33	2	2553	2	KIAA1267	17	44248690	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1001937	44248690	36946520	423	21870											
TTLL6	284076	broad.mit.edu	37	chr17	46862508	46862508	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcatttttcctttcacctCtgacactcaagagcaagtca	10	15	4	12	0	5	2	4	1	1	1	6	2	6	2	2	0	1	1	2	0	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:46862508C>G	uc010wlo.1	-	14	1852	c.1817G>C	c.(1816-1818)AGA>ACA	p.R606T	TTLL6_uc002iob.2_Missense_Mutation_p.R299T|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Missense_Mutation_p.R359T|TTLL6_uc002iod.2_Missense_Mutation_p.R453T	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	558						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						CCTTTCACCTCTGACACTCAA	0.527													37	63					0	0	0	0	G	46862508	G	G	46862508	3	3	122	1	0	0	0	0	1	0	0	0	16799	913	32	2	870	2	TTLL6	17	46862508	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2613818	46862508	34332702	424	21871											
SNF8	11267	broad.mit.edu	37	chr17	47022055	47022055	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgctcacctctgcaagtttCttcttggcgatggcgccagc	5	12	10	14	2	4	0	1	0	3	0	4	1	4	0	2	2	3	3	2	2	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:47022055C>G	uc002ioj.2	-	1	100	c.42G>C	c.(40-42)AAG>AAC	p.K14N	SNF8_uc002iok.2_Missense_Mutation_p.K14N	NM_007241	NP_009172	Q96H20	SNF8_HUMAN	EAP30 subunit of ELL complex	14					cellular membrane organization|endosome transport|protein transport|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytosol|late endosome membrane|transcription factor complex	transcription factor binding				0						CTGCAAGTTTCTTCTTGGCGA	0.522													86	128					0	0	0	0	G	47022055	G	G	47022055	3	3	122	1	0	0	0	0	1	0	0	0	14910	912	32	2	766	2	SNF8	17	47022055	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	159547	47022055	34173155	425	21872											
SPAG9	9043	broad.mit.edu	37	chr17	49054546	49054546	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacaagacaccataagagctGtaattctcacaaaagagaag	19	7	7	8	0	1	3	1	0	1	3	2	4	1	3	1	0	2	2	1	0	7	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:49054546G>C	uc002itc.2	-	27	3655	c.3446C>G	c.(3445-3447)ACA>AGA	p.T1149R	SPAG9_uc002itb.2_Missense_Mutation_p.T1135R|SPAG9_uc002itd.2_Missense_Mutation_p.T1139R|SPAG9_uc002ita.2_Missense_Mutation_p.T992R	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	1149					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			CATAAGAGCTGTAATTCTCAC	0.388													55	82					0	0	0	0	C	49054546	C	C	49054546	3	2	122	1	0	0	0	0	1	0	0	0	15051	1377	48	4	535	4	SPAG9	17	49054546	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2032491	49054546	32140664	426	21873											
TEX2	55852	broad.mit.edu	37	chr17	62290455	62290455	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctatctctcttgtgggctCaccagtggactttgggtggt	4	16	12	9	0	4	0	1	0	3	0	5	1	4	1	1	4	0	1	1	4	1	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:62290455C>T	uc002jec.2	-	2	1296	c.1123G>A	c.(1123-1125)GAG>AAG	p.E375K	TEX2_uc002jed.2_Missense_Mutation_p.E375K|TEX2_uc002jee.2_Missense_Mutation_p.E375K	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	375					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CTTGTGGGCTCACCAGTGGAC	0.483													41	109					0	0	0	0	T	62290455	T	T	62290455	3	4	122	1	0	0	0	0	1	0	0	0	15847	835	29	2	2325	2	TEX2	17	62290455	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	13235909	62290455	18904755	427	21874											
PRKAR1A	5573	broad.mit.edu	37	chr17	66524033	66524033	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaattccttagtaaagtctCtattttaggtgagttgtaaa	12	16	9	4	0	1	1	0	1	1	0	3	2	2	2	1	2	0	3	1	2	8	8			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:66524033C>G	uc002jhg.2	+	8	941	c.761C>G	c.(760-762)TCT>TGT	p.S254C	PRKAR1A_uc002jhh.2_Missense_Mutation_p.S254C|PRKAR1A_uc002jhi.2_Missense_Mutation_p.S254C|PRKAR1A_uc002jhj.2_Missense_Mutation_p.S254C|PRKAR1A_uc002jhk.2_Missense_Mutation_p.S130C|PRKAR1A_uc002jhl.2_Missense_Mutation_p.S254C|PRKAR1A_uc002jhm.2_Missense_Mutation_p.S254C	NM_212471	NP_997636	P10644	KAP0_HUMAN	cAMP-dependent protein kinase, regulatory	254	cAMP 1.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|lung(3)|thyroid(2)|soft_tissue(2)|breast(1)	12	Breast(10;1.64e-13)					AGTAAAGTCTCTATTTTAGGT	0.353			T|Mis|N|F|S	RET	papillary thyroid	myxoma|endocrine|papillary thyroid			Carney_Complex|Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial|Cardiac_Myxomas_Familial_Clustering_of				29	77					0	0	0	0	G	66524033	G	G	66524033	3	3	122	1	0	0	0	0	1	0	0	0	12565	913	32	2	787	2	PRKAR1A	17	66524033	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	4233578	66524033	14671177	428	21875											
CDC42EP4	23580	broad.mit.edu	37	chr17	71281968	71281968	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccactcctccttgtccatGatgctgaggacgtcacccag	7	10	8	16	1	1	2	1	2	0	0	5	3	5	3	5	1	1	1	5	1	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:71281968G>A	uc002jjn.2	-	2	819	c.672C>T	c.(670-672)ATC>ATT	p.I224I	CDC42EP4_uc002jjo.2_Silent_p.I224I|CDC42EP4_uc002jjp.1_Silent_p.I154I	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	224					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			CCTTGTCCATGATGCTGAGGA	0.657													25	72					0	0	0	0	A	71281968	A	A	71281968	2	1	122	1	0	0	0	0	0	0	0	1	3093	1280	45	2		2	CDC42EP4	17	71281968	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4757935	71281968	9913242	429	21876											
SDK2	54549	broad.mit.edu	37	chr17	71364591	71364591	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggggtgctccgaggcccatCcccagcggcgttgaaggcgg	5	5	18	13	4	0	1	0	1	0	0	2	2	2	1	4	6	2	2	4	6	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:71364591C>T	uc010dfm.2	-	37	5122	c.5122G>A	c.(5122-5124)GAT>AAT	p.D1708N	SDK2_uc002jjt.3_Missense_Mutation_p.D848N|SDK2_uc010dfn.2_Missense_Mutation_p.D1387N	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1708	Fibronectin type-III 11.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						CGAGGCCCATCCCCAGCGGCG	0.647													3	21					0	0	0	0	T	71364591	T	T	71364591	3	4	122	1	0	0	0	0	1	0	0	0	14034	855	30	2	1432	2	SDK2	17	71364591	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	82623	71364591	9830619	430	21877											
SDK2	54549	broad.mit.edu	37	chr17	71415334	71415334	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taacccttgagaattccattCtggtggctctcaggaggcgg	8	11	12	10	1	2	1	1	1	2	1	4	3	3	2	2	5	1	1	2	5	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:71415334C>G	uc010dfm.2	-	16	2157	c.2157G>C	c.(2155-2157)CAG>CAC	p.Q719H	SDK2_uc010dfn.2_Missense_Mutation_p.Q398H	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	719	Extracellular (Potential).|Fibronectin type-III 2.				cell adhesion	integral to membrane				ovary(2)	2						GAATTCCATTCTGGTGGCTCT	0.617													7	17					0	0	0	0	G	71415334	G	G	71415334	3	3	122	1	0	0	0	0	1	0	0	0	14034	912	32	2	4481	2	SDK2	17	71415334	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	50743	71415334	9779876	431	21878											
NT5C	30833	broad.mit.edu	37	chr17	73127368	73127368	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcttcgtacacactggcCactttatcctgaaagacaag	11	9	10	11	1	0	2	0	1	0	1	2	2	1	2	2	3	1	2	2	3	4	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:73127368C>T	uc002jmx.2	-	2	258	c.183G>A	c.(181-183)GTG>GTA	p.V61V	NT5C_uc002jmy.2_RNA	NM_014595	NP_055410	Q8TCD5	NT5C_HUMAN	5',3'-nucleotidase, cytosolic	61					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine deoxyribonucleotide catabolic process|pyrimidine nucleoside catabolic process	cytosol|nucleus	5'-nucleotidase activity|metal ion binding|pyrimidine nucleotide binding				0	all_lung(278;0.14)|Lung NSC(278;0.168)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)			ACACACTGGCCACTTTATCCT	0.652													7	21					0	0	0	0	T	73127368	T	T	73127368	2	4	122	1	0	0	0	0	0	0	0	1	10738	581	21	4		4	NT5C	17	73127368	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1712034	73127368	8067842	432	21879											
LLGL2	3993	broad.mit.edu	37	chr17	73569168	73569168	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagggctcaagagtgcggcGggtcagcgtggcccacttcg	6	6	18	11	4	2	1	2	0	0	1	3	2	2	2	1	5	2	1	1	5	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:73569168G>A	uc002joh.2	+	20	2688	c.2534G>A	c.(2533-2535)CGG>CAG	p.R845Q	LLGL2_uc002joi.2_Missense_Mutation_p.R845Q|LLGL2_uc010dgg.1_Missense_Mutation_p.R845Q|LLGL2_uc002joj.2_Missense_Mutation_p.R834Q|LLGL2_uc010wsd.1_Missense_Mutation_p.R472Q	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	845	WD 13.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			AGAGTGCGGCGGGTCAGCGTG	0.647													30	19					0	0	0	0	A	73569168	A	A	73569168	3	1	122	1	0	0	0	0	1	0	0	0	8876	1116	39	1	2643	1	LLGL2	17	73569168	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	441800	73569168	7626042	433	21880											
ITGB4	3691	broad.mit.edu	37	chr17	73736024	73736024	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacctgatggcctctgaccActtggacacgcccatgctgc	8	8	10	15	1	1	2	0	2	1	0	1	4	1	3	4	2	3	1	4	2	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:73736024A>G	uc002jpg.2	+	20	2505	c.2318A>G	c.(2317-2319)CAC>CGC	p.H773R	ITGB4_uc002jph.2_Missense_Mutation_p.H773R|ITGB4_uc010dgo.2_Missense_Mutation_p.H773R|ITGB4_uc002jpi.3_Missense_Mutation_p.H773R|ITGB4_uc010dgp.1_Missense_Mutation_p.H773R|ITGB4_uc002jpj.2_Missense_Mutation_p.H773R	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	773	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCTCTGACCACTTGGACACG	0.612													13	57					0	0	0	0	G	73736024	G	G	73736024	3	3	122	1	0	0	0	0	1	0	0	0	7936	159	6	5	2392	5	ITGB4	17	73736024	Missense_Mutation	SNP	A	TCGA-CR-6472-01A-11D-1870-08	166856	73736024	7459186	434	21881											
EVPL	2125	broad.mit.edu	37	chr17	74006418	74006418	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagaactctaccacttccttCtcctccagcctctccaaggg	8	11	5	17	0	3	1	0	0	3	1	7	1	5	1	6	1	3	0	6	1	4	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:74006418C>T	uc002jqi.2	-	22	3096	c.2868G>A	c.(2866-2868)GAG>GAA	p.E956E	EVPL_uc010wss.1_Silent_p.E978E|EVPL_uc010wst.1_Silent_p.E426E	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	956	Central fibrous rod domain.|Potential.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						CCACTTCCTTCTCCTCCAGCC	0.682													16	55					0	0	0	0	T	74006418	T	T	74006418	2	4	122	1	0	0	0	0	0	0	0	1	5316	912	32	2		2	EVPL	17	74006418	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	270394	74006418	7188792	435	21882											
CYTH1	9267	broad.mit.edu	37	chr17	76694965	76694965	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggttcatggcaatgaacctCtccacagtgggcttatcttt	8	13	9	11	1	3	1	1	1	2	0	4	1	3	1	2	3	1	3	2	3	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:76694965C>G	uc002jvw.2	-	8	707	c.636G>C	c.(634-636)GAG>GAC	p.E212D	CYTH1_uc010wtw.1_Missense_Mutation_p.E153D|CYTH1_uc010wtx.1_Missense_Mutation_p.E153D	NM_017456	NP_059430	Q15438	CYH1_HUMAN	cytohesin 1 isoform 2	212					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						CAATGAACCTCTCCACAGTGG	0.483													122	344					0	0	0	0	G	76694965	G	G	76694965	3	3	122	1	0	0	0	0	1	0	0	0	4220	912	32	2	584	2	CYTH1	17	76694965	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2688547	76694965	4500245	436	21883											
RNF213	57674	broad.mit.edu	37	chr17	78348306	78348306	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggataggtacctggtgtacGgcgatgaatacaaggctctc	10	10	13	8	2	1	1	0	1	1	0	2	3	1	2	1	5	3	3	1	5	6	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:78348306G>A	uc002jyh.1	+	25	7433	c.7210G>A	c.(7210-7212)GGC>AGC	p.G2404S	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.G786S	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CCTGGTGTACGGCGATGAATA	0.562													22	69					0	0	0	0	A	78348306	A	A	78348306	3	1	122	1	0	0	0	0	1	0	0	0	13542	1116	39	1	13504	1	RNF213	17	78348306	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1653341	78348306	2846904	437	21884											
ASPSCR1	79058	broad.mit.edu	37	chr17	79954344	79954344	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcaagaccccaggaagcctGggctcgtcagcgtcggctgg	7	5	16	13	3	1	1	1	0	0	1	3	2	1	2	3	5	2	3	3	5	2	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr17:79954344G>C	uc002kcx.2	+	7	652	c.555G>C	c.(553-555)CTG>CTC	p.L185L	ASPSCR1_uc002kcw.1_Silent_p.L185L|ASPSCR1_uc002kcy.2_Silent_p.L185L|ASPSCR1_uc002kcz.2_Intron|ASPSCR1_uc002kda.2_Silent_p.L108L|ASPSCR1_uc002kdb.1_Silent_p.L108L	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	185							protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CAGGAAGCCTGGGCTCGTCAG	0.667			T	TFE3	alveolar soft part sarcoma								8	36					0	0	0	0	C	79954344	C	C	79954344	2	2	122	1	0	0	0	0	0	0	0	1	1061	1335	47	4		4	ASPSCR1	17	79954344	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1606038	79954344	1240866	438	21885											
SMCHD1	23347	broad.mit.edu	37	chr18	2700762	2700762	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtactcctcctaagaagaGagggcttgcaccaattgaat	12	10	10	9	0	0	3	0	1	0	2	2	4	2	3	3	1	2	3	3	1	5	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:2700762G>C	uc002klm.3	+	12	1682	c.1493G>C	c.(1492-1494)AGA>ACA	p.R498T	SMCHD1_uc002klk.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	498					chromosome organization		ATP binding				0						CCTAAGAAGAGAGGGCTTGCA	0.338													24	31					0	0	0	0	C	2700762	C	C	2700762	3	2	122	1	0	0	0	0	1	0	0	0	14852	942	33	2	1539	2	SMCHD1	18	2700762	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08		2700762	75376486	439	21886											
SMCHD1	23347	broad.mit.edu	37	chr18	2724980	2724980	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccaagggccctgtaaactCttgtcaaggcaaggtaagca	13	7	11	10	0	2	0	1	0	1	0	2	0	2	0	2	3	3	4	2	3	6	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:2724980C>A	uc002klm.3	+	21	2876	c.2687C>A	c.(2686-2688)TCT>TAT	p.S896Y	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	896					chromosome organization		ATP binding				0						CCTGTAAACTCTTGTCAAGGC	0.323													10	10					0.000673444	0.000686542	1	0	A	2724980	A	A	2724980	3	1	122	1	0	0	0	0	1	0	0	0	14852	913	32	2	2769	2	SMCHD1	18	2724980	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	24218	2724980	75352268	440	21887											
ABHD3	171586	broad.mit.edu	37	chr18	19237110	19237110	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgttttacaaacatatgtcgGtgcctggaacaaaagaattt	14	13	8	6	1	0	1	0	0	0	1	1	2	0	2	1	2	4	1	1	2	7	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:19237110G>A	uc002ktl.2	-	7	986	c.846C>T	c.(844-846)CAC>CAT	p.H282H	ABHD3_uc002ktm.2_Silent_p.H229H|ABHD3_uc002ktk.2_Silent_p.H87H|ABHD3_uc002ktn.2_Silent_p.H59H	NM_138340	NP_612213	Q8WU67	ABHD3_HUMAN	alpha/beta hydrolase domain containing protein	282						integral to membrane	carboxylesterase activity			central_nervous_system(1)	1						ACATATGTCGGTGCCTGGAAC	0.299													7	16					0	0	0	0	A	19237110	A	A	19237110	2	1	122	1	0	0	0	0	0	0	0	1	83	1252	44	4		4	ABHD3	18	19237110	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	16512130	19237110	58840138	441	21888											
TTC39C	125488	broad.mit.edu	37	chr18	21705475	21705475	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgtacttgtggaaagctcttCcaaactgttccttccccaac	9	13	6	13	0	1	0	0	0	1	0	4	1	4	1	4	1	4	3	4	1	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:21705475C>G	uc002kuw.2	+	10	1833	c.1381C>G	c.(1381-1383)CCA>GCA	p.P461A	TTC39C_uc002kuu.2_Missense_Mutation_p.P400A	NM_001135993	NP_001129465	Q8N584	TT39C_HUMAN	tetratricopeptide repeat domain 39C isoform 1	461							binding			ovary(1)	1						GAAAGCTCTTCCAAACTGTTC	0.463													25	40					0	0	0	0	G	21705475	G	G	21705475	3	3	122	1	0	0	0	0	1	0	0	0	16777	855	30	2	1419	2	TTC39C	18	21705475	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2468365	21705475	56371773	442	21889											
ASXL3	80816	broad.mit.edu	37	chr18	31314318	31314318	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcggataaggcaagaaattGagaaggaaaagaaaacagaa	22	4	12	3	1	0	4	0	1	0	4	0	7	0	6	0	3	2	1	0	3	9	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:31314318G>T	uc010dmg.1	+	10	1076	c.1021G>T	c.(1021-1023)GAG>TAG	p.E341*	ASXL3_uc002kxq.2_Nonsense_Mutation_p.E48*	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	341					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GCAAGAAATTGAGAAGGAAAA	0.323													8	21					9.70103e-10	1.01699e-09	1	0	T	31314318	T	T	31314318	4	4	122	1	0	0	0	0	0	1	0	0	1070	1291	45	2	1059	2	ASXL3	18	31314318	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	9608843	31314318	46762930	443	21890											
ONECUT2	9480	broad.mit.edu	37	chr18	55103474	55103474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	accctcacccgcaccaccatCcgcaccaccaccaccaccac	11	2	2	26	2	1	0	1	0	0	0	2	0	2	0	10	0	0	2	10	0	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:55103474C>T	uc002lgo.2	+	1	558	c.526C>T	c.(526-528)CCG>TCG	p.P176S		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	176	Poly-His.				organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		gcaccaccatccgcaccacca	0.478													6	5					0	0	0	0	T	55103474	T	T	55103474	3	4	122	1	0	0	0	0	1	0	0	0	10923	855	30	2	528	2	ONECUT2	18	55103474	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	23789156	55103474	22973774	444	21891											
KIAA1468	57614	broad.mit.edu	37	chr18	59895656	59895656	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acagtggacagcatccagatGtaaatagttcagacaaggga	16	7	11	7	0	1	2	1	0	0	2	2	4	2	4	1	2	1	3	1	2	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:59895656G>A	uc002lil.2	+	8	1488	c.1273G>A	c.(1273-1275)GTA>ATA	p.V425I	KIAA1468_uc002lik.1_Missense_Mutation_p.V425I|KIAA1468_uc010xel.1_Missense_Mutation_p.V425I|KIAA1468_uc002lim.2_Missense_Mutation_p.V69I	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	425							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				GCATCCAGATGTAAATAGTTC	0.428													26	50					0	0	0	0	A	59895656	A	A	59895656	3	1	122	1	0	0	0	0	1	0	0	0	8275	1377	48	4	1303	4	KIAA1468	18	59895656	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4792182	59895656	18181592	445	21892											
PHLPP1	23239	broad.mit.edu	37	chr18	60642700	60642700	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atatcaagcatgaccctgtgGatccaggaggatccttcacc	11	9	9	12	0	2	1	2	1	0	0	4	4	4	4	4	3	1	1	4	3	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:60642700G>C	uc002lis.2	+	17	2468	c.2290G>C	c.(2290-2292)GAT>CAT	p.D764H		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1276	PP2C-like.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						TGACCCTGTGGATCCAGGAGG	0.522													64	97					0	0	0	0	C	60642700	C	C	60642700	3	2	122	1	0	0	0	0	1	0	0	0	11909	1174	41	2	3888	2	PHLPP1	18	60642700	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	747044	60642700	17434548	446	21893											
PHLPP1	23239	broad.mit.edu	37	chr18	60642822	60642822	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagctgtgaagaagagctGaagaggattaaacagcacaa	18	6	12	5	0	0	6	0	3	0	3	0	7	0	7	0	1	4	3	0	1	6	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:60642822G>A	uc002lis.2	+	17	2590	c.2412G>A	c.(2410-2412)CTG>CTA	p.L804L		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1316	PP2C-like.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						AAGAAGAGCTGAAGAGGATTA	0.443													51	87					0	0	0	0	A	60642822	A	A	60642822	2	1	122	1	0	0	0	0	0	0	0	1	11909	1277	45	2		2	PHLPP1	18	60642822	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	122	60642822	17434426	447	21894											
VPS4B	9525	broad.mit.edu	37	chr18	61064456	61064456	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctcgggcatggggttcCggcaagggaatataaattcg	9	9	15	8	3	0	0	0	0	0	0	3	1	1	1	1	5	1	5	1	5	5	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:61064456C>T	uc002lix.2	-	9	1163	c.903G>A	c.(901-903)CCG>CCA	p.P301P	VPS4B_uc010dpx.2_Silent_p.P301P|VPS4B_uc010dpy.2_Silent_p.P183P|VPS4B_uc010dpz.1_Silent_p.P183P	NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B	301					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1						CATGGGGTTCCGGCAAGGGAA	0.393													6	58					0	0	0	0	T	61064456	T	T	61064456	2	4	122	1	0	0	0	0	0	0	0	1	17281	639	23	1		1	VPS4B	18	61064456	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	421634	61064456	17012792	448	21895											
ZNF407	55628	broad.mit.edu	37	chr18	72344264	72344264	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggtaatagctttcgtcgacGaagcagcactttcaccttga	10	11	10	10	3	1	1	1	1	0	0	3	3	1	1	1	1	3	4	1	1	3	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr18:72344264G>A	uc002llw.2	+	1	1346	c.1289G>A	c.(1288-1290)CGA>CAA	p.R430Q	ZNF407_uc010xfc.1_Missense_Mutation_p.R430Q|ZNF407_uc010dqu.1_Missense_Mutation_p.R430Q|ZNF407_uc002llu.2_Missense_Mutation_p.R429Q	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TTTCGTCGACGAAGCAGCACT	0.428													44	52					0	0	0	0	A	72344264	A	A	72344264	3	1	122	1	0	0	0	0	1	0	0	0	17954	1058	37	1	1291	1	ZNF407	18	72344264	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	11279808	72344264	5732984	449	21896											
POLRMT	5442	broad.mit.edu	37	chr19	619625	619625	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccggaggcgcttctcaatCtgcaggcgcccgccatagcg	6	7	12	16	5	2	0	1	0	2	0	4	1	3	1	3	3	2	2	3	3	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:619625C>A	uc002lpf.1	-	13	3083	c.3027G>T	c.(3025-3027)CAG>CAT	p.Q1009H		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	1009	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTCTCAATCTGCAGGCGCC	0.612													27	51					7.76418e-22	8.44926e-22	1	0	A	619625	A	A	619625	3	1	122	1	0	0	0	0	1	0	0	0	12293	912	32	2	701	2	POLRMT	19	619625	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08		619625	58509358	450	21897											
CNN2	1265	broad.mit.edu	37	chr19	1032417	1032417	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaacaagctacagccgggctCcgtccccaagatcaaccgct	11	5	9	16	3	1	1	1	0	0	1	3	2	3	1	5	1	5	3	5	1	5	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:1032417C>G	uc002lqu.2	+	3	575	c.212C>G	c.(211-213)TCC>TGC	p.S71C	CNN2_uc002lqt.1_Missense_Mutation_p.S71C|CNN2_uc010drz.1_Intron|CNN2_uc002lqv.2_Missense_Mutation_p.S71C|CNN2_uc010xgb.1_Missense_Mutation_p.S71C|CNN2_uc010xgc.1_Missense_Mutation_p.S71C	NM_004368	NP_004359	Q99439	CNN2_HUMAN	calponin 2 isoform a	71	CH.				actomyosin structure organization|cellular response to mechanical stimulus|regulation of actin filament-based process	cell-cell junction|stress fiber	actin binding|calmodulin binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCCGGGCTCCGTCCCCAAG	0.622													40	67					0	0	0	0	G	1032417	G	G	1032417	3	3	122	1	0	0	0	0	1	0	0	0	3625	855	30	2	222	2	CNN2	19	1032417	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	412792	1032417	58096566	451	21898											
REXO1	57455	broad.mit.edu	37	chr19	1828053	1828053	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccgggagctggccctgctGaggtgccgggccgagtagtt	4	8	17	12	3	0	1	0	1	0	0	1	3	1	2	4	4	3	4	4	4	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:1828053G>A	uc002lua.3	-	2	830	c.735C>T	c.(733-735)CTC>CTT	p.L245L	REXO1_uc010dsr.1_Silent_p.L199L	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	245						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCCCTGCTGAGGTGCCGGG	0.677													23	43					0	0	0	0	A	1828053	A	A	1828053	2	1	122	1	0	0	0	0	0	0	0	1	13306	1277	45	2		2	REXO1	19	1828053	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	795636	1828053	57300930	452	21899											
SGTA	6449	broad.mit.edu	37	chr19	2759262	2759262	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttgtcacttacagctgctGaatctggggattgttcatta	8	15	11	7	0	3	1	2	1	1	0	3	2	3	2	0	3	3	4	0	3	3	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:2759262G>A	uc002lwi.1	-	9	877	c.730C>T	c.(730-732)CAG>TAG	p.Q244*		NM_003021	NP_003012	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide	244					interspecies interaction between organisms	cytoplasm	protein binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TACAGCTGCTGAATCTGGGGA	0.328													62	145					0	0	0	0	A	2759262	A	A	2759262	4	1	122	1	0	0	0	0	0	1	0	0	14290	1299	45	2	223	2	SGTA	19	2759262	Nonsense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	931209	2759262	56369721	453	21900											
ZNF555	148254	broad.mit.edu	37	chr19	2851477	2851477	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtttcagatgatgaaactCaatttaaggccagtgggtca	12	12	11	6	0	3	3	3	2	0	1	3	3	3	3	1	3	1	1	1	3	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:2851477C>G	uc002lwo.2	+	3	231	c.142C>G	c.(142-144)CAA>GAA	p.Q48E	ZNF555_uc002lwn.3_Missense_Mutation_p.Q48E	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	48	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGATGAAACTCAATTTAAGGC	0.393													18	25					0	0	0	0	G	2851477	G	G	2851477	3	3	122	1	0	0	0	0	1	0	0	0	18053	827	29	2	152	2	ZNF555	19	2851477	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	92215	2851477	56277506	454	21901											
MUC16	94025	broad.mit.edu	37	chr19	9066076	9066076	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagaagtgaagtcacaggaaGaggagaggaggagatagtca	17	4	17	3	0	2	5	2	1	0	4	2	10	2	7	0	4	0	0	0	4	4	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:9066076G>A	uc002mkp.2	-	3	21574	c.21370C>T	c.(21370-21372)CTT>TTT	p.L7124F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7126	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCACAGGAAGAGGAGAGGAG	0.517													35	89					0	0	0	0	A	9066076	A	A	9066076	3	1	122	1	0	0	0	0	1	0	0	0	10026	942	33	2	22481	2	MUC16	19	9066076	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	6214599	9066076	50062907	455	21902											
COL5A3	50509	broad.mit.edu	37	chr19	10104345	10104345	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggccatcgaagccacgatCaccctgtccagagacaccag	12	4	10	15	2	1	1	1	0	0	1	3	5	2	1	5	1	1	0	5	1	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:10104345C>T	uc002mmq.1	-	18	1731	c.1645G>A	c.(1645-1647)GAT>AAT	p.D549N		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	549	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			AAGCCACGATCACCCTGTCCA	0.587													18	47					0	0	0	0	T	10104345	T	T	10104345	3	4	122	1	0	0	0	0	1	0	0	0	3713	826	29	2	3792	2	COL5A3	19	10104345	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1038269	10104345	49024638	456	21903											
RGL3	57139	broad.mit.edu	37	chr19	11517470	11517470	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctggggaccttgaggcatGagcccttcctcttcctccgc	5	10	11	15	1	1	2	0	2	1	0	4	3	4	3	5	3	2	2	5	3	0	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:11517470G>A	uc002mrp.2	-	6	772	c.708C>T	c.(706-708)CTC>CTT	p.L236L	RGL3_uc002mrn.2_5'UTR|RGL3_uc002mrm.2_5'UTR|RGL3_uc002mro.2_Silent_p.L236L	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	236					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						CTTGAGGCATGAGCCCTTCCT	0.557													22	34					0	0	0	0	A	11517470	A	A	11517470	2	1	122	1	0	0	0	0	0	0	0	1	13343	1277	45	2		2	RGL3	19	11517470	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1413125	11517470	47611513	457	21904											
ECSIT	51295	broad.mit.edu	37	chr19	11618651	11618651	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccagggcggcctgctgatCgggactctggattcctggtg	4	9	17	11	2	1	1	0	1	1	0	3	3	2	3	3	6	1	1	3	6	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:11618651C>T	uc002msb.2	-	6	945	c.811G>A	c.(811-813)GAT>AAT	p.D271N	ZNF653_uc002mrz.1_5'Flank|ECSIT_uc002msa.1_RNA|ECSIT_uc010dyc.1_Intron|ECSIT_uc010dyd.2_Intron|ECSIT_uc010xma.1_Missense_Mutation_p.D57N	NM_016581	NP_057665	Q9BQ95	ECSIT_HUMAN	evolutionarily conserved signaling intermediate	271					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			ovary(1)	1						GCCTGCTGATCGGGACTCTGG	0.632													14	30					0	0	0	0	T	11618651	T	T	11618651	3	4	122	1	0	0	0	0	1	0	0	0	4922	884	31	1	496	1	ECSIT	19	11618651	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	101181	11618651	47510332	458	21905											
ZNF69	7620	broad.mit.edu	37	chr19	11998761	11998761	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccctgctgtagtcacaggaGgtgtagagaggaccccggga	9	6	16	10	1	1	1	1	0	0	1	1	5	1	4	3	4	1	3	3	4	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:11998761G>T	uc002mst.3	+	1	92	c.23G>T	c.(22-24)AGG>ATG	p.R8M		NM_021915	NP_068734	Q9UC07	ZNF69_HUMAN	zinc finger protein 69	8						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				Lung(535;0.011)		AGTCACAGGAGGTGTAGAGAG	0.637													15	41					4.7546e-09	4.95961e-09	1	0	T	11998761	T	T	11998761	3	4	122	1	0	0	0	0	1	0	0	0	18162	1000	35	4	25	4	ZNF69	19	11998761	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	380110	11998761	47130222	459	21906											
ZNF700	90592	broad.mit.edu	37	chr19	12060754	12060754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcaaaccttcagatgcatGaaaggactcacactggagag	14	7	9	11	0	3	3	3	1	0	2	3	5	3	4	2	2	2	1	2	2	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:12060754G>A	uc002msu.2	+	4	2041	c.1915G>A	c.(1915-1917)GAA>AAA	p.E639K	ZNF700_uc010xme.1_Missense_Mutation_p.E657K|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	639	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCAGATGCATGAAAGGACTCA	0.423													32	62					0	0	0	0	A	12060754	A	A	12060754	3	1	122	1	0	0	0	0	1	0	0	0	18171	1291	45	2	1929	2	ZNF700	19	12060754	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	61993	12060754	47068229	460	21907											
PRKACA	5566	broad.mit.edu	37	chr19	14203941	14203941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cccctaaaactcagaaaactCcttgccacacttctcattga	13	10	3	15	0	2	2	2	1	1	1	4	2	3	2	4	0	3	0	4	0	4	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:14203941C>G	uc002myc.2	-	10	1239	c.1039G>C	c.(1039-1041)GAG>CAG	p.E347Q	SAMD1_uc010xnl.1_5'Flank|PRKACA_uc002myb.2_Missense_Mutation_p.E339Q	NM_002730	NP_002721	P17612	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit	347	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1						TCAGAAAACTCCTTGCCACAC	0.453													12	21					0	0	0	0	G	14203941	G	G	14203941	3	3	122	1	0	0	0	0	1	0	0	0	12559	864	30	2	20	2	PRKACA	19	14203941	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2143187	14203941	44925042	461	21908											
TECR	9524	broad.mit.edu	37	chr19	14676041	14676041	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gacgcggaagatcccataccCcaccaagaaccccttcacgt	12	5	7	17	3	1	2	1	0	0	2	2	4	2	3	6	1	2	0	6	1	4	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:14676041C>T	uc002mza.2	+	11	819	c.692C>T	c.(691-693)CCC>CTC	p.P231L	TECR_uc002mzb.2_Missense_Mutation_p.P246L|TECR_uc010xns.1_Missense_Mutation_p.P76L|TECR_uc002mzc.2_Missense_Mutation_p.P76L|TECR_uc002mzd.2_Missense_Mutation_p.P261L|TECR_uc002mze.2_Missense_Mutation_p.P57L|TECR_uc002mzf.1_Missense_Mutation_p.P45L	NM_138501	NP_612510	Q9NZ01	TECR_HUMAN	glycoprotein, synaptic 2	231					fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity				0						ATCCCATACCCCACCAAGAAC	0.637													39	60					0	0	0	0	T	14676041	T	T	14676041	3	4	122	1	0	0	0	0	1	0	0	0	15811	623	22	4	734	4	TECR	19	14676041	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	472100	14676041	44452942	462	21909											
SYDE1	85360	broad.mit.edu	37	chr19	15224468	15224468	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggcagaccccgaagtggtGactcggccccgcggtcgagg	6	5	16	14	5	0	2	0	1	0	1	2	4	0	2	4	5	0	1	4	5	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:15224468G>A	uc002nah.1	+	8	1933	c.1902G>A	c.(1900-1902)GTG>GTA	p.V634V	SYDE1_uc002nai.1_Silent_p.V567V|SYDE1_uc002naj.1_Silent_p.V291V	NM_033025	NP_149014	Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1	634					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|pancreas(1)	2						CCGAAGTGGTGACTCGGCCCC	0.697													38	81					0	0	0	0	A	15224468	A	A	15224468	2	1	122	1	0	0	0	0	0	0	0	1	15501	1277	45	2		2	SYDE1	19	15224468	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	548427	15224468	43904515	463	21910											
NOTCH3	4854	broad.mit.edu	37	chr19	15292503	15292503	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgggccgcaggggttgctCaggcactcatccacatcgcg	6	6	13	16	4	2	0	2	0	0	0	4	0	3	0	3	4	1	4	3	4	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:15292503C>G	uc002nan.2	-	17	2752	c.2676G>C	c.(2674-2676)CTG>CTC	p.L892L	NOTCH3_uc002nao.1_Silent_p.L840L	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	892	Extracellular (Potential).|EGF-like 23; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			AGGGGTTGCTCAGGCACTCAT	0.677													3	1					0	0	0	0	G	15292503	G	G	15292503	2	3	122	1	0	0	0	0	0	0	0	1	10604	813	29	2		2	NOTCH3	19	15292503	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	68035	15292503	43836480	464	21911											
PGLYRP2	114770	broad.mit.edu	37	chr19	15586745	15586745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagctggtcccagcagccctCagttcccaggtctggatggc	6	8	13	14	0	2	0	1	0	1	0	4	2	4	1	3	4	3	3	3	4	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:15586745C>T	uc002nbf.3	-	2	869	c.736G>A	c.(736-738)GAG>AAG	p.E246K	PGLYRP2_uc002nbg.3_Missense_Mutation_p.E246K	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	246					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						CAGCAGCCCTCAGTTCCCAGG	0.617													22	40					0	0	0	0	T	15586745	T	T	15586745	3	4	122	1	0	0	0	0	1	0	0	0	11849	835	29	2	1010	2	PGLYRP2	19	15586745	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	294242	15586745	43542238	465	21912											
SLC27A1	376497	broad.mit.edu	37	chr19	17608070	17608070	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accccgtcccccaggtggttCagtacatcggggagatctgc	7	8	12	14	2	2	1	1	0	1	1	4	2	3	1	4	4	2	2	4	4	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:17608070C>G	uc002ngu.1	+	7	1053	c.1003C>G	c.(1003-1005)CAG>GAG	p.Q335E	SLC27A1_uc002ngt.1_Missense_Mutation_p.Q67E|SLC27A1_uc010xpp.1_Missense_Mutation_p.Q156E|SLC27A1_uc002ngv.1_5'UTR	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	335	Sufficient for oligomerization (By similarity).|Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0						CCAGGTGGTTCAGTACATCGG	0.711													10	19					0	0	0	0	G	17608070	G	G	17608070	3	3	122	1	0	0	0	0	1	0	0	0	14589	827	29	2	1029	2	SLC27A1	19	17608070	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2021325	17608070	41520913	466	21913											
B3GNT3	10331	broad.mit.edu	37	chr19	17918980	17918980	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctcccctagcaactatgtgCgccgcgagctgctgcggcgc	5	7	12	17	5	0	0	0	0	0	0	1	1	1	0	4	1	6	3	4	1	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:17918980C>T	uc002nhk.1	+	2	449	c.364C>T	c.(364-366)CGC>TGC	p.R122C	B3GNT3_uc002nhl.1_Missense_Mutation_p.R122C|B3GNT3_uc010ebd.1_Missense_Mutation_p.R122C|B3GNT3_uc010ebe.1_Missense_Mutation_p.R122C	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	122	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						CAACTATGTGCGCCGCGAGCT	0.677													3	24					0	0	0	0	T	17918980	T	T	17918980	3	4	122	1	0	0	0	0	1	0	0	0	1260	768	27	1	366	1	B3GNT3	19	17918980	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	310910	17918980	41210003	467	21914											
UPF1	5976	broad.mit.edu	37	chr19	18956861	18956861	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaccagccagttgttggctGagttgaacttcgaggaagat	11	10	13	7	1	0	4	0	2	0	2	1	6	0	5	2	2	2	4	2	2	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:18956861G>A	uc002nkg.2	+	2	579	c.304G>A	c.(304-306)GAG>AAG	p.E102K	UPF1_uc002nkf.2_Missense_Mutation_p.E102K	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	102	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTTGTTGGCTGAGTTGAACTT	0.577													23	26					0	0	0	0	A	18956861	A	A	18956861	3	1	122	1	0	0	0	0	1	0	0	0	17071	1291	45	2	310	2	UPF1	19	18956861	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1037881	18956861	40172122	468	21915											
UPF1	5976	broad.mit.edu	37	chr19	18967806	18967806	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgagccggagtgcatggttCccgtggtcctcggggccaag	5	7	16	13	4	0	0	0	0	0	0	3	2	2	1	5	5	2	2	5	5	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:18967806C>A	uc002nkg.2	+	14	2253	c.1978C>A	c.(1978-1980)CCC>ACC	p.P660T	UPF1_uc002nkf.2_Missense_Mutation_p.P649T|UPF1_uc002nkh.2_5'Flank	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	660					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTGCATGGTTCCCGTGGTCCT	0.582													39	63					2.54651e-27	2.80027e-27	1	0	A	18967806	A	A	18967806	3	1	122	1	0	0	0	0	1	0	0	0	17071	855	30	2	1999	2	UPF1	19	18967806	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	10945	18967806	40161177	469	21916											
ZNF99	7652	broad.mit.edu	37	chr19	22940553	22940553	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattatctcatgttttctaaGagttgaggactggctaaaag	13	14	9	5	0	2	2	1	1	2	1	3	3	2	3	0	2	0	3	0	2	5	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:22940553G>C	uc010xrh.1	-	5	1885	c.1885C>G	c.(1885-1887)CTT>GTT	p.L629V		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTTTTCTAAGAGTTGAGGAC	0.363													24	49					0	0	0	0	C	22940553	C	C	22940553	3	2	122	1	0	0	0	0	1	0	0	0	18271	942	33	2	1239	2	ZNF99	19	22940553	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3972747	22940553	36188430	470	21917											
ZNF99	7652	broad.mit.edu	37	chr19	22952052	22952052	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataacattcctatataaattCtgctgagccatgtccaggca	13	12	6	10	0	1	1	0	1	1	0	3	1	3	1	3	1	3	2	3	1	5	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:22952052C>A	uc010xrh.1	-	2	141	c.141G>T	c.(139-141)CAG>CAT	p.Q47H		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TATATAAATTCTGCTGAGCCA	0.383													41	74					5.44703e-19	5.89704e-19	1	0	A	22952052	A	A	22952052	3	1	122	1	0	0	0	0	1	0	0	0	18271	912	32	2	2995	2	ZNF99	19	22952052	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	11499	22952052	36176931	471	21918											
DPY19L3	147991	broad.mit.edu	37	chr19	32949405	32949405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagcattcgttgttgcctttCataatctcaggtatggtata	9	17	8	7	1	2	0	2	0	1	0	4	0	2	0	1	2	2	5	1	2	5	9			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:32949405C>T	uc002ntg.2	+	12	1488	c.1312C>T	c.(1312-1314)CAT>TAT	p.H438Y	DPY19L3_uc002nth.1_Missense_Mutation_p.H438Y|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	438						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					TGTTGCCTTTCATAATCTCAG	0.348													81	117					0	0	0	0	T	32949405	T	T	32949405	3	4	122	1	0	0	0	0	1	0	0	0	4764	826	29	2	1354	2	DPY19L3	19	32949405	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	9997353	32949405	26179578	472	21919											
PDCD2L	84306	broad.mit.edu	37	chr19	34904736	34904736	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaagcgaattgctgcttgtCaggagcagattttgaggtaa	11	12	13	5	1	1	3	1	2	0	1	1	5	1	4	0	2	4	4	0	2	3	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:34904736C>G	uc002nvj.2	+	5	814	c.781C>G	c.(781-783)CAG>GAG	p.Q261E		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	261						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			TGCTGCTTGTCAGGAGCAGAT	0.328													11	31					0	0	0	0	G	34904736	G	G	34904736	3	3	122	1	0	0	0	0	1	0	0	0	11674	827	29	2	799	2	PDCD2L	19	34904736	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1955331	34904736	24224247	473	21920											
LRFN3	79414	broad.mit.edu	37	chr19	36431159	36431159	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgcgcgtccccacctgctCtgggcggccgctacttctgg	2	9	12	18	4	2	0	0	0	2	0	3	0	3	0	5	3	3	2	5	3	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:36431159C>T	uc002oco.2	+	2	1284	c.832C>T	c.(832-834)CTG>TTG	p.L278L		NM_024509	NP_078785	Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III	278	LRRCT.|Extracellular (Potential).				cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCCACCTGCTCTGGGCGGCCG	0.711													8	17					0	0	0	0	T	36431159	T	T	36431159	2	4	122	1	0	0	0	0	0	0	0	1	8989	912	32	2		2	LRFN3	19	36431159	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1526423	36431159	22697824	474	21921											
RYR1	6261	broad.mit.edu	37	chr19	38976417	38976417	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acctgccaggcccactgcgcGcaggctactatgacctcctc	7	7	9	18	2	0	1	0	1	0	0	2	1	1	1	5	2	3	2	5	2	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:38976417G>A	uc002oit.2	+	34	5252	c.5122G>A	c.(5122-5124)GCA>ACA	p.A1708T	RYR1_uc002oiu.2_Missense_Mutation_p.A1708T	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1708	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCACTGCGCGCAGGCTACTA	0.647													25	44					0	0	0	0	A	38976417	A	A	38976417	3	1	122	1	0	0	0	0	1	0	0	0	13833	1087	38	1	5256	1	RYR1	19	38976417	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2545258	38976417	20152566	475	21922											
PLEKHG2	64857	broad.mit.edu	37	chr19	39915437	39915437	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgagagaggaggctctctaGacattcagggcctctcaccc	9	8	11	13	0	3	3	2	1	2	2	5	5	3	4	2	3	0	1	2	3	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:39915437G>C	uc010xuz.1	+	19	3989	c.3664G>C	c.(3664-3666)GAC>CAC	p.D1222H	PLEKHG2_uc010xuy.1_Missense_Mutation_p.D1163H|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.D1000H	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	1222					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGGCTCTCTAGACATTCAGGG	0.532													83	163					0	0	0	0	C	39915437	C	C	39915437	3	2	122	1	0	0	0	0	1	0	0	0	12124	942	33	2	3734	2	PLEKHG2	19	39915437	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	939020	39915437	19213546	476	21923											
SUPT5H	6829	broad.mit.edu	37	chr19	39962116	39962116	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacatccatgtgaaagacatCgttaaggtcattgatggccc	13	10	9	9	1	1	3	1	2	0	1	3	3	2	3	2	2	1	1	2	2	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:39962116C>T	uc002olo.3	+	19	1976	c.1797C>T	c.(1795-1797)ATC>ATT	p.I599I	SUPT5H_uc002olp.3_Silent_p.I599I|SUPT5H_uc002olq.3_Silent_p.I595I|SUPT5H_uc002oln.3_Silent_p.I599I|SUPT5H_uc002olr.3_Silent_p.I599I|SUPT5H_uc002ols.1_Silent_p.I222I|SUPT5H_uc010egp.1_5'Flank	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	599	KOW 4.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TGAAAGACATCGTTAAGGTCA	0.512													29	51					0	0	0	0	T	39962116	T	T	39962116	2	4	122	1	0	0	0	0	0	0	0	1	15465	874	31	1		1	SUPT5H	19	39962116	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	46679	39962116	19166867	477	21924											
SPTBN4	57731	broad.mit.edu	37	chr19	40996095	40996095	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aacgtgggttcgcatgacatCgtggatgggaatcaccggct	9	9	14	9	4	1	1	1	1	0	0	3	3	1	3	1	4	1	3	1	4	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:40996095C>G	uc002ony.2	+	4	521	c.435C>G	c.(433-435)ATC>ATG	p.I145M	SPTBN4_uc002onx.2_Missense_Mutation_p.I145M|SPTBN4_uc002onz.2_Missense_Mutation_p.I145M	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	145	CH 1.|Actin-binding.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CGCATGACATCGTGGATGGGA	0.637													26	35					0	0	0	0	G	40996095	G	G	40996095	3	3	122	1	0	0	0	0	1	0	0	0	15187	874	31	3	445	3	SPTBN4	19	40996095	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1033979	40996095	18132888	478	21925											
EXOSC5	56915	broad.mit.edu	37	chr19	41895711	41895711	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccagcacgagggtcccatCagagtccagggcgcaggcga	10	4	14	13	3	1	1	1	0	0	1	4	3	4	1	3	3	1	2	3	3	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:41895711C>G	uc002oqo.2	-	4	507	c.484G>C	c.(484-486)GAT>CAT	p.D162H	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Intron	NM_020158	NP_064543	Q9NQT4	EXOS5_HUMAN	exosome component Rrp46	162					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|protein binding|RNA binding				0						AGGGTCCCATCAGAGTCCAGG	0.617													49	73					0	0	0	0	G	41895711	G	G	41895711	3	3	122	1	0	0	0	0	1	0	0	0	5342	826	29	2	235	2	EXOSC5	19	41895711	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	899616	41895711	17233272	479	21926											
ARHGEF1	9138	broad.mit.edu	37	chr19	42406794	42406803	+	Frame_Shift_Del	DEL	TGTGCCTTCG	-	-																															aacgcaaggaccctcggttcTgtgccttcgtgcaggtgagg																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:42406794_42406803delTGTGCCTTCG	uc002orx.2	+	17	1718_1727	c.1609_1618delTGTGCCTTCG	c.(1609-1620)TGTGCCTTCGTGfs	p.C537fs	ARHGEF1_uc002ory.2_Frame_Shift_Del_p.C504fs|ARHGEF1_uc002orz.2_Frame_Shift_Del_p.C375fs|ARHGEF1_uc002osa.2_Frame_Shift_Del_p.C552fs|ARHGEF1_uc002osb.2_Frame_Shift_Del_p.C519fs|ARHGEF1_uc002osc.2_Frame_Shift_Del_p.C291fs|ARHGEF1_uc002osd.2_Frame_Shift_Del_p.C196fs|ARHGEF1_uc002ose.2_5'Flank	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	537_540	DH.				cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		CCCTCGGTTCTGTGCCTTCGTGCAGGTGAG	0.443													---	---	---								-	42406803	-	-	42406794	7	5	122	1	0	1	0	1	0	0	0	0	893	1580	55	0	1720	0	ARHGEF1	19	42406794	Frame_Shift_Del	DEL	TGTGCCTTCG	TCGA-CR-6472-01A-11D-1870-08	511083	42406794	16722189	480	21927											
GRIK5	2901	broad.mit.edu	37	chr19	42558072	42558072	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacccgcccggtcagcccatCatactctacctggcagggtg	7	7	11	16	2	3	0	2	0	1	0	3	1	3	0	4	3	3	1	4	3	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:42558072C>G	uc002osj.1	-	9	1101	c.1066G>C	c.(1066-1068)GAT>CAT	p.D356H	GRIK5_uc010eib.1_Missense_Mutation_p.D275H	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	356	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GTCAGCCCATCATACTCTACC	0.617													12	17					0	0	0	0	G	42558072	G	G	42558072	3	3	122	1	0	0	0	0	1	0	0	0	6816	826	29	2	1920	2	GRIK5	19	42558072	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	151278	42558072	16570911	481	21928											
TMEM145	284339	broad.mit.edu	37	chr19	42827884	42827884	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgggaacgtgacgtttatCagcgactcggtgcccaactt	9	11	11	10	4	1	1	1	1	0	0	2	3	1	2	1	2	4	1	1	2	4	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:42827884C>T	uc002otk.1	+	14	1396	c.1344C>T	c.(1342-1344)ATC>ATT	p.I448I	MEGF8_uc002otl.3_5'Flank	NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	448						integral to membrane					0		Prostate(69;0.00682)				TGACGTTTATCAGCGACTCGG	0.682													26	47					0	0	0	0	T	42827884	T	T	42827884	2	4	122	1	0	0	0	0	0	0	0	1	16125	816	29	2		2	TMEM145	19	42827884	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	269812	42827884	16301099	482	21929											
PVR	5817	broad.mit.edu	37	chr19	45161157	45161157	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctaggagctcgccaggcaGaactgaccgtccaggtcaaa	11	5	11	14	2	1	2	1	1	0	1	3	3	2	3	4	3	2	2	4	3	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:45161157G>A	uc002ozm.2	+	5	1269	c.970G>A	c.(970-972)GAA>AAA	p.E324K	PVR_uc010ejs.2_Missense_Mutation_p.E324K|PVR_uc010xxb.1_Missense_Mutation_p.E324K|PVR_uc010xxc.1_Missense_Mutation_p.E324K|PVR_uc002ozn.2_Missense_Mutation_p.E269K	NM_006505	NP_006496	P15151	PVR_HUMAN	poliovirus receptor isoform alpha	324	Extracellular (Potential).|Ig-like C2-type 2.				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity				0	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		TCGCCAGGCAGAACTGACCGT	0.572											OREG0025540	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	25					0	0	0	0	A	45161157	A	A	45161157	3	1	122	1	0	0	0	0	1	0	0	0	12902	943	33	2	988	2	PVR	19	45161157	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2333273	45161157	13967826	483	21930											
HIF3A	64344	broad.mit.edu	37	chr19	46800352	46800352	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccatggcgctggggctgcagCgcgcaaggtactgaagttcg	7	7	16	11	4	0	1	0	1	0	0	1	1	0	1	1	4	3	6	1	4	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:46800352C>G	uc002peh.2	+	1	48	c.19C>G	c.(19-21)CGC>GGC	p.R7G	HIF3A_uc002pef.1_Missense_Mutation_p.R7G|HIF3A_uc002peg.3_Missense_Mutation_p.R7G|HIF3A_uc010xxx.1_5'Flank|HIF3A_uc002pei.3_5'Flank|HIF3A_uc002pej.1_5'Flank|HIF3A_uc002pek.2_5'Flank|HIF3A_uc010xxy.1_5'Flank	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GGGGCTGCAGCGCGCAAGGTA	0.716													17	29					0	0	0	0	G	46800352	G	G	46800352	3	3	122	1	0	0	0	0	1	0	0	0	7144	768	27	3	21	3	HIF3A	19	46800352	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1639195	46800352	12328631	484	21931											
ZC3H4	23211	broad.mit.edu	37	chr19	47597670	47597670	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttggatttcctcctcttCttcgacctccttttctcttt	2	21	4	14	1	3	0	0	0	3	0	8	2	6	1	4	1	1	1	4	1	0	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:47597670C>T	uc002pga.3	-	3	395	c.357G>A	c.(355-357)AAG>AAA	p.K119K	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	119	Potential.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TCCTCCTCTTCTTCGACCTCC	0.562													137	280					0	0	0	0	T	47597670	T	T	47597670	2	4	122	1	0	0	0	0	0	0	0	1	17637	912	32	2		2	ZC3H4	19	47597670	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	797318	47597670	11531313	485	21932											
SLC8A2	6543	broad.mit.edu	37	chr19	47960796	47960796	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccgcttgtcggccatcCaggcgaataccacgcacacc	9	5	10	17	4	0	0	0	0	0	0	2	1	1	0	5	2	2	3	5	2	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:47960796C>A	uc002pgx.2	-	3	1009	c.731G>T	c.(730-732)TGG>TTG	p.W244L	SLC8A2_uc010xyq.1_5'UTR|SLC8A2_uc010xyr.1_Intron|SLC8A2_uc010ele.2_Missense_Mutation_p.W244L	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	244	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		GTCGGCCATCCAGGCGAATAC	0.677													24	35					5.61819e-17	6.00993e-17	1	0	A	47960796	A	A	47960796	3	1	122	1	0	0	0	0	1	0	0	0	14771	595	21	4	2066	4	SLC8A2	19	47960796	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	363126	47960796	11168187	486	21933											
TULP2	7288	broad.mit.edu	37	chr19	49391429	49391429	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgtgccaccctcgcctttCagggccttggacaactcttc	5	11	8	17	2	2	0	1	0	1	0	5	1	3	1	5	2	2	0	5	2	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:49391429C>A	uc002pkz.2	-	8	877	c.726G>T	c.(724-726)CTG>CTT	p.L242L		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	242					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		CCTCGCCTTTCAGGGCCTTGG	0.592													35	39					7.53189e-24	8.23924e-24	1	0	A	49391429	A	A	49391429	2	1	122	1	0	0	0	0	0	0	0	1	16842	813	29	2		2	TULP2	19	49391429	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1430633	49391429	9737554	487	21934											
LIN7B	64130	broad.mit.edu	37	chr19	49621200	49621200	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggttgtccgttacacaccgcGagtgctggaggagatggagg	8	8	17	8	3	0	1	0	0	0	1	1	5	1	3	2	5	2	3	2	5	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:49621200G>A	uc002pmp.2	+	5	571	c.527G>A	c.(526-528)CGA>CAA	p.R176Q	PPFIA3_uc002pmr.2_5'Flank|PPFIA3_uc010yai.1_5'Flank	NM_022165	NP_071448	Q9HAP6	LIN7B_HUMAN	lin-7 homolog B	176					exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein domain specific binding				0		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;5e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000191)|GBM - Glioblastoma multiforme(486;0.00449)|Epithelial(262;0.01)		TACACACCGCGAGTGCTGGAG	0.657													34	78					0	0	0	0	A	49621200	A	A	49621200	3	1	122	1	0	0	0	0	1	0	0	0	8853	1058	37	1	545	1	LIN7B	19	49621200	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	229771	49621200	9507783	488	21935											
HRC	3270	broad.mit.edu	37	chr19	49657828	49657828	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctgagacatcctcatcctCttcactcccatggcctcggt	7	12	6	16	1	4	1	2	1	2	1	8	2	7	1	4	2	0	0	4	2	0	1	rs139799783		TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:49657828C>G	uc002pmv.2	-	1	854	c.667G>C	c.(667-669)GAG>CAG	p.E223Q		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	223	4 X tandem repeats, acidic.|2-4.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		TCCTCATCCTCTTCACTCCCA	0.363													14	36					0	0	0	0	G	49657828	G	G	49657828	3	3	122	1	0	0	0	0	1	0	0	0	7391	922	32	2	1456	2	HRC	19	49657828	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	36628	49657828	9471155	489	21936											
HRC	3270	broad.mit.edu	37	chr19	49657906	49657907	+	In_Frame_Ins	INS	-	CTG	CTG																															tcttcctcctcctcctcctcINSctcctcctcttctccttcat																										TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:49657906_49657907insCTG	uc002pmv.2	-	1	775_776	c.588_589insCAG	c.(586-591)insCAG	p.196_197insQ		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	196_197	4 X tandem repeats, acidic.|Glu-rich (acidic).|1-1.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		tcctcctcctcctcctcctctt	0.446													---	---	---								CTG	49657907	CTG	CTG	49657906	7	5	122	1	0	1	1	0	0	0	0	0	7391	864	30	0	1534	0	HRC	19	49657906	In_Frame_Ins	INS	-	TCGA-CR-6472-01A-11D-1870-08	78	49657906	9471077	490	21937											
AP2A1	160	broad.mit.edu	37	chr19	50285913	50285913	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcctggccctgcactgcatCgccaacgtgggcagccggga	6	6	14	15	3	0	0	0	0	0	0	1	1	0	1	4	3	5	3	4	3	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:50285913C>T	uc002ppn.2	+	4	616	c.405C>T	c.(403-405)ATC>ATT	p.I135I	AP2A1_uc010enj.1_Intron|AP2A1_uc002ppo.2_Silent_p.I135I	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	135					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		TGCACTGCATCGCCAACGTGG	0.647													6	20					0	0	0	0	T	50285913	T	T	50285913	2	4	122	1	0	0	0	0	0	0	0	1	739	874	31	1		1	AP2A1	19	50285913	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	628007	50285913	8843070	491	21938											
VRK3	51231	broad.mit.edu	37	chr19	50510833	50510833	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacagagtgtaccttcataGagaatgccctggttgtccct	9	11	11	10	0	1	2	1	0	0	2	2	4	2	3	3	2	2	2	3	2	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:50510833G>C	uc002prg.2	-	5	638	c.540C>G	c.(538-540)CTC>CTG	p.L180L	VRK3_uc002prh.1_Silent_p.L180L|VRK3_uc002pri.1_Silent_p.L130L|VRK3_uc010ens.2_Silent_p.L180L|VRK3_uc010ybl.1_Silent_p.L130L|VRK3_uc010ybm.1_5'UTR|VRK3_uc002prj.1_Silent_p.L130L|VRK3_uc002prk.1_Silent_p.L180L|VRK3_uc010ent.1_5'UTR|VRK3_uc002prl.2_Silent_p.L180L|VRK3_uc010ybn.1_Silent_p.L180L	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	180	Protein kinase.					nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		TACCTTCATAGAGAATGCCCT	0.582													24	74					0	0	0	0	C	50510833	C	C	50510833	2	2	122	1	0	0	0	0	0	0	0	1	17289	929	33	2		2	VRK3	19	50510833	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	224920	50510833	8618150	492	21939											
ZNF473	25888	broad.mit.edu	37	chr19	50542425	50542425	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgtgtttcaggaatttgTgaccctcaaggatgtcggca	9	13	11	8	1	2	1	2	1	0	0	3	3	2	3	1	3	1	2	1	3	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:50542425T>G	uc002prn.2	+	3	254	c.17T>G	c.(16-18)GTG>GGG	p.V6G	ZNF473_uc002prm.2_Missense_Mutation_p.V6G|ZNF473_uc010ybo.1_5'UTR	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	6	KRAB.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		CAGGAATTTGTGACCCTCAAG	0.577													45	97					0	0	0	0	G	50542425	G	G	50542425	3	3	122	1	0	0	0	0	1	0	0	0	17998	1696	59	5	23	5	ZNF473	19	50542425	Missense_Mutation	SNP	T	TCGA-CR-6472-01A-11D-1870-08	31592	50542425	8586558	493	21940											
ZNF432	9668	broad.mit.edu	37	chr19	52537236	52537236	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actacatatacaagatttctCttctgtatgaatttgctgat	12	17	5	7	0	2	3	0	2	2	1	3	3	2	3	0	0	3	2	0	0	6	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:52537236C>G	uc002pyk.2	-	5	2014	c.1696G>C	c.(1696-1698)GAG>CAG	p.E566Q		NM_014650	NP_055465	O94892	ZN432_HUMAN	zinc finger protein 432	566					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|pancreas(1)	3		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CAAGATTTCTCTTCTGTATGA	0.398													39	87					0	0	0	0	G	52537236	G	G	52537236	3	3	122	1	0	0	0	0	1	0	0	0	17973	922	32	2	266	2	ZNF432	19	52537236	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1994811	52537236	6591747	494	21941											
KIR3DL3	115653	broad.mit.edu	37	chr19	55247444	55247444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccctccctccaggactctGatgaacaagaccctcaggag	10	8	8	15	0	2	3	1	2	1	1	5	5	5	5	4	2	1	0	4	2	2	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:55247444G>A	uc002qgu.1	+	8	1132	c.1114G>A	c.(1114-1116)GAT>AAT	p.D372N	KIR2DL3_uc002qgv.2_Intron|KIR2DL3_uc002qgx.2_5'Flank|KIR2DL3_uc002qgy.2_5'Flank|KIR2DL3_uc010erw.1_5'Flank	NM_153443	NP_703144	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three	372	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		CCAGGACTCTGATGAACAAGA	0.542													64	155					0	0	0	0	A	55247444	A	A	55247444	3	1	122	1	0	0	0	0	1	0	0	0	8361	1290	45	2	1144	2	KIR3DL3	19	55247444	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2710208	55247444	3881539	495	21942											
TNNI3	7137	broad.mit.edu	37	chr19	55668994	55668994	+	5'Flank	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggaatggcaggaggcagggcGaggacaggggcgtttggagg	9	4	23	5	2	0	0	0	0	0	0	0	5	0	4	0	10	0	3	0	10	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:55668994G>C	uc002qjg.3	-						TNNI3_uc010yft.1_5'UTR	NM_000363	NP_000354	P19429	TNNI3_HUMAN	troponin I, cardiac						cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			lung(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GAGGCAGGGCGAGGACAGGGG	0.682													39	72					0	0	0	0	C	55668994	C	C	55668994	1	2	122	0	1	0	0	0	0	0	0	0	16394	1073	37	3		3	TNNI3	19	55668994	5'Flank	SNP	G	TCGA-CR-6472-01A-11D-1870-08	421550	55668994	3459989	496	21943											
SBK2	646643	broad.mit.edu	37	chr19	56041144	56041144	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgctcccactgcctccgcctCgccctcccgctgcctccagg	2	7	8	24	4	0	0	0	0	0	0	5	0	4	0	8	1	2	2	8	1	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:56041144C>T	uc010ygc.1	-	3	1003	c.1003G>A	c.(1003-1005)GAG>AAG	p.E335K		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	335							ATP binding|protein serine/threonine kinase activity				0						GCCTCCGCCTCGCCCTCCCGC	0.731													17	23					0	0	0	0	T	56041144	T	T	56041144	3	4	122	1	0	0	0	0	1	0	0	0	13926	893	31	1	46	1	SBK2	19	56041144	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	372150	56041144	3087839	497	21944											
ZNF547	284306	broad.mit.edu	37	chr19	57888534	57888534	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggatgaggaggcacctttaGagccaggtgtttctgtagga	10	10	15	6	0	1	2	0	1	1	1	1	5	1	5	2	5	1	3	2	5	2	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:57888534G>C	uc002qol.2	+	4	383	c.190G>C	c.(190-192)GAG>CAG	p.E64Q	ZNF547_uc002qpm.3_5'UTR|ZNF547_uc010ygx.1_Missense_Mutation_p.E64Q	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	64	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGCACCTTTAGAGCCAGGTGT	0.507													22	38					0	0	0	0	C	57888534	C	C	57888534	3	2	122	1	0	0	0	0	1	0	0	0	18046	943	33	2	200	2	ZNF547	19	57888534	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1847390	57888534	1240449	498	21945											
ZNF211	10520	broad.mit.edu	37	chr19	58153116	58153116	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccaccggagacttcacactgGagaaagaccctatgagtgca	13	6	10	12	1	1	4	1	1	0	3	1	6	1	4	3	2	1	1	3	2	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr19:58153116G>C	uc002qpq.2	+	3	1442	c.1262G>C	c.(1261-1263)GGA>GCA	p.G421A	ZNF211_uc010yhb.1_Missense_Mutation_p.G425A|ZNF211_uc002qpp.2_Missense_Mutation_p.G434A|ZNF211_uc002qpr.2_Missense_Mutation_p.G485A|ZNF211_uc002qps.2_Missense_Mutation_p.G486A|ZNF211_uc002qpt.2_Missense_Mutation_p.G433A|ZNF211_uc010yhc.1_Missense_Mutation_p.G433A|ZNF211_uc010yhd.1_Missense_Mutation_p.G360A|ZNF211_uc010yhe.1_Missense_Mutation_p.G412A	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	421						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTTCACACTGGAGAAAGACCC	0.478													26	57					0	0	0	0	C	58153116	C	C	58153116	3	2	122	1	0	0	0	0	1	0	0	0	17834	1174	41	2	1315	2	ZNF211	19	58153116	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	264582	58153116	975867	499	21946											
DEFB126	81623	broad.mit.edu	37	chr20	126135	126135	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgaagagatgcatgtaaaGaatggttgggcaatgtgcgg	12	9	15	5	1	0	3	0	1	0	2	0	4	0	3	1	3	2	4	1	3	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:126135G>C	uc002wcx.2	+	2	156	c.138G>C	c.(136-138)AAG>AAC	p.K46N		NM_030931	NP_112193	Q9BYW3	DB126_HUMAN	defensin, beta 126 preproprotein	46					defense response to bacterium	extracellular region					0		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			TGCATGTAAAGAATGGTTGGG	0.403													27	55					0	0	0	0	C	126135	C	C	126135	3	2	122	1	0	0	0	0	1	0	0	0	4433	933	33	2	144	2	DEFB126	20	126135	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08		126135	62899385	500	21947											
ATRN	8455	broad.mit.edu	37	chr20	3553417	3553417	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtttcaatagtctcctcctCagcgacatcctggtattcac	8	13	7	13	1	4	0	3	0	1	0	7	1	6	0	3	2	1	2	3	2	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:3553417C>T	uc002wim.2	+	12	2001	c.1911C>T	c.(1909-1911)CTC>CTT	p.L637L	ATRN_uc002wil.2_Silent_p.L637L	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	637	Extracellular (Potential).|Kelch 6.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						GTCTCCTCCTCAGCGACATCC	0.468													40	110					0	0	0	0	T	3553417	T	T	3553417	2	4	122	1	0	0	0	0	0	0	0	1	1208	813	29	2		2	ATRN	20	3553417	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	3427282	3553417	59472103	501	21948											
POLR3F	10621	broad.mit.edu	37	chr20	18448199	18448199	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcctgacgcggatccggtcGaaatagaaaacaggtaaacc	14	5	11	11	5	0	2	0	1	0	1	2	4	1	3	3	3	2	1	3	3	6	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:18448199G>A	uc002wqv.2	+	1	167	c.49G>A	c.(49-51)GAA>AAA	p.E17K	C20orf12_uc002wqr.3_5'Flank|C20orf12_uc002wqs.3_5'Flank|C20orf12_uc002wqq.3_5'Flank|C20orf12_uc010zsa.1_5'Flank|C20orf12_uc002wqu.1_5'Flank|C20orf12_uc010gct.1_5'Flank|POLR3F_uc002wqw.2_RNA|POLR3F_uc002wqx.2_5'UTR	NM_006466	NP_006457	Q9H1D9	RPC6_HUMAN	DNA-directed RNA polymerase III 39 kDa	17					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|protein binding				0						GGATCCGGTCGAAATAGAAAA	0.622													22	40					0	0	0	0	A	18448199	A	A	18448199	3	1	122	1	0	0	0	0	1	0	0	0	12288	1059	37	1	51	1	POLR3F	20	18448199	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	14894782	18448199	44577321	502	21949											
RALGAPA2	57186	broad.mit.edu	37	chr20	20601168	20601168	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcttgggcaacatcttttCtatctggctcctccatgaac	7	15	6	13	0	4	1	0	1	4	0	6	1	6	1	2	2	2	2	2	2	3	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:20601168C>G	uc002wrz.2	-	11	1483	c.1340G>C	c.(1339-1341)AGA>ACA	p.R447T	RALGAPA2_uc010gcx.2_Missense_Mutation_p.R151T|RALGAPA2_uc010zsg.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	447					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						AACATCTTTTCTATCTGGCTC	0.393													31	47					0	0	0	0	G	20601168	G	G	20601168	3	3	122	1	0	0	0	0	1	0	0	0	13079	913	32	2	4397	2	RALGAPA2	20	20601168	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2152969	20601168	42424352	503	21950											
TP53INP2	58476	broad.mit.edu	37	chr20	33297096	33297096	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgcccccgcgggccgccctCcgcccgcgccctccttgatg	1	6	11	23	6	0	1	0	1	0	0	2	1	2	1	8	1	1	0	8	1	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:33297096C>G	uc002xau.1	+	4	516	c.181C>G	c.(181-183)CCG>GCG	p.P61A		NM_021202	NP_067025	Q8IXH6	T53I2_HUMAN	tumor protein p53 inducible nuclear protein 2	61						nucleus					0						gggccgccctccgcccgcgcc	0.517													7	8					0	0	0	0	G	33297096	G	G	33297096	3	3	122	1	0	0	0	0	1	0	0	0	16456	855	30	2	187	2	TP53INP2	20	33297096	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	12695928	33297096	29728424	504	21951											
MMP24	10893	broad.mit.edu	37	chr20	33862274	33862274	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacgatgtgccgggctccgtGaacgccgtggccgtggtcat	6	8	15	12	6	1	1	1	1	0	0	2	2	2	1	4	3	3	1	4	3	2	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:33862274G>A	uc002xbu.2	+	9	1803	c.1800G>A	c.(1798-1800)GTG>GTA	p.V600V	EDEM2_uc010zuv.1_Intron	NM_006690	NP_006681	Q9Y5R2	MMP24_HUMAN	matrix metalloproteinase 24 preproprotein	600	Extracellular (Potential).				proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CGGGCTCCGTGAACGCCGTGG	0.627													37	64					0	0	0	0	A	33862274	A	A	33862274	2	1	122	1	0	0	0	0	0	0	0	1	9714	1277	45	2		2	MMP24	20	33862274	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	565178	33862274	29163246	505	21952											
DLGAP4	22839	broad.mit.edu	37	chr20	35155433	35155433	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaggcccagaccaggctctGagaccatgcaggaggaaaga	13	3	15	10	0	1	3	0	1	1	3	1	7	1	6	3	5	1	2	3	5	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:35155433G>C	uc002xff.2	+	13	3404	c.2969G>C	c.(2968-2970)TGA>TCA	p.*990S	DLGAP4_uc010zvp.1_Nonstop_Mutation_p.*990S|DLGAP4_uc002xfg.2_Nonstop_Mutation_p.*286S|DLGAP4_uc002xfh.2_Nonstop_Mutation_p.*454S|DLGAP4_uc002xfi.2_3'UTR|DLGAP4_uc002xfj.2_Nonstop_Mutation_p.*286S|uc002xfk.3_Intron	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	990					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				ACCAGGCTCTGAGACCATGCA	0.502													20	25					0	0	0	0	C	35155433	C	C	35155433	4	2	122	1	0	0	0	0	0	0	0	0	4584	1285	45	2	3139	2	DLGAP4	20	35155433	Nonstop_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1293159	35155433	27870087	506	21953											
SFRS6	6431	broad.mit.edu	37	chr20	42088733	42088733	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccacaaggaacgaacaaatGagggtgtaattgagtttcgc	14	8	11	8	2	0	2	0	2	0	0	1	4	0	3	1	2	2	2	1	2	5	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:42088733G>C	uc010zwg.1	+	4	612	c.442G>C	c.(442-444)GAG>CAG	p.E148Q	SFRS6_uc002xki.2_Missense_Mutation_p.E19Q|SFRS6_uc002xkk.2_Missense_Mutation_p.E148Q	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	148	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACGAACAAATGAGGGTGTAAT	0.418													23	51					0	0	0	0	C	42088733	C	C	42088733	3	2	122	1	0	0	0	0	1	0	0	0	14246	1291	45	2	456	2	SFRS6	20	42088733	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	6933300	42088733	20936787	507	21954											
JPH2	57158	broad.mit.edu	37	chr20	42815224	42815224	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cctcaaagccaaagttccagGagccagagtattcgccctgg	11	7	10	13	1	1	1	1	0	0	1	3	2	2	2	5	2	2	2	5	2	3	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:42815224G>C	uc002xli.1	-	1	995	c.122C>G	c.(121-123)TCC>TGC	p.S41C	JPH2_uc002xlj.2_Missense_Mutation_p.S41C	NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	41	Gly-rich.|Cytoplasmic (Potential).|MORN 2.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			AAAGTTCCAGGAGCCAGAGTA	0.617													10	24					0	0	0	0	C	42815224	C	C	42815224	3	2	122	1	0	0	0	0	1	0	0	0	8000	1174	41	2	2003	2	JPH2	20	42815224	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	726491	42815224	20210296	508	21955											
KCNK15	60598	broad.mit.edu	37	chr20	43374746	43374746	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taccgcgagctggagcgcctGgcgctccaggctgagcccca	6	5	14	16	4	0	1	0	1	0	0	1	3	1	2	5	3	4	3	5	3	1	1	rs112757483		TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:43374746G>A	uc002xmr.2	+	1	259	c.195G>A	c.(193-195)CTG>CTA	p.L65L		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	65						integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				TGGAGCGCCTGGCGCTCCAGG	0.697													6	11					0	0	0	0	A	43374746	A	A	43374746	2	1	122	1	0	0	0	0	0	0	0	1	8101	1335	47	4		4	KCNK15	20	43374746	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	559522	43374746	19650774	509	21956											
PABPC1L	80336	broad.mit.edu	37	chr20	43566728	43566728	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctctacccccttatccatGatgtccacacccagctggct	7	11	6	17	0	1	1	0	1	1	0	4	1	3	1	5	1	2	2	5	1	2	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:43566728G>A	uc010ggv.1	+	13	1754	c.1672G>A	c.(1672-1674)GAT>AAT	p.D558N	PABPC1L_uc010zwq.1_RNA|PABPC1L_uc002xmv.2_RNA|PABPC1L_uc002xmw.2_Missense_Mutation_p.D112N|PABPC1L_uc002xmx.2_Missense_Mutation_p.D112N	NM_001124756	NP_001118228	Q4VXU2	PAP1L_HUMAN	poly(A)-binding protein, cytoplasmic 1-like	558	PABC.						nucleotide binding|RNA binding			ovary(1)	1						CCTTATCCATGATGTCCACAC	0.572													21	29					0	0	0	0	A	43566728	A	A	43566728	3	1	122	1	0	0	0	0	1	0	0	0	11418	1290	45	2	1722	2	PABPC1L	20	43566728	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	191982	43566728	19458792	510	21957											
DNTTIP1	116092	broad.mit.edu	37	chr20	44433831	44433831	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccacctttgtgttgggatCtcgagccaacaagtaagttt	10	13	9	9	1	1	0	0	0	1	0	2	2	1	1	3	1	3	3	3	1	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:44433831C>G	uc002xpk.2	+	9	718	c.650C>G	c.(649-651)TCT>TGT	p.S217C		NM_052951	NP_443183	Q9H147	TDIF1_HUMAN	terminal deoxynucleotidyltransferase interacting	217						nucleus				ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.0122)				GTGTTGGGATCTCGAGCCAAC	0.463													96	151					0	0	0	0	G	44433831	G	G	44433831	3	3	122	1	0	0	0	0	1	0	0	0	4703	913	32	2	684	2	DNTTIP1	20	44433831	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	867103	44433831	18591689	511	21958											
STAU1	6780	broad.mit.edu	37	chr20	47733708	47733708	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgccgataccatggctgatCagaggtggctgagaggagca	10	8	15	8	1	1	3	1	2	0	2	1	6	1	4	2	4	3	3	2	4	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:47733708C>G	uc002xud.2	-	12	1998	c.1587G>C	c.(1585-1587)CTG>CTC	p.L529L	STAU1_uc002xua.2_Silent_p.L448L|STAU1_uc002xub.2_Silent_p.L454L|STAU1_uc002xuc.2_Silent_p.L448L|STAU1_uc002xue.2_Silent_p.L448L|STAU1_uc002xuf.2_Silent_p.L454L|STAU1_uc002xug.2_Silent_p.L529L	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	529						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			CATGGCTGATCAGAGGTGGCT	0.478													28	32					0	0	0	0	G	47733708	G	G	47733708	2	3	122	1	0	0	0	0	0	0	0	1	15338	813	29	2		2	STAU1	20	47733708	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	3299877	47733708	15291812	512	21959											
ZNF217	7764	broad.mit.edu	37	chr20	52198855	52198855	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtccgcatgtgatttttaaGaaaccaaggctccttgaatc	11	13	8	9	1	0	3	0	2	0	1	3	3	2	3	3	1	1	2	3	1	4	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:52198855G>A	uc002xwq.3	-	1	782	c.511C>T	c.(511-513)CTT>TTT	p.L171F	ZNF217_uc010gij.1_Missense_Mutation_p.L163F	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	171	C2H2-type 3.				negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			TGATTTTTAAGAAACCAAGGC	0.463													64	125					0	0	0	0	A	52198855	A	A	52198855	3	1	122	1	0	0	0	0	1	0	0	0	17839	942	33	2	2651	2	ZNF217	20	52198855	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	4465147	52198855	10826665	513	21960											
ZBP1	81030	broad.mit.edu	37	chr20	56188387	56188387	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctcttcttccagaatcttCtgcaaaataatattcaactg	12	15	4	10	0	5	1	1	0	4	1	6	1	6	1	1	0	3	2	1	0	6	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:56188387C>G	uc002xyo.2	-	5	784	c.503_splice	c.e5-1	p.E168_splice	ZBP1_uc010gjm.2_Intron|ZBP1_uc002xyp.2_Splice_Site_p.E93_splice|ZBP1_uc010zzn.1_Intron	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a							cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			CCAGAATCTTCTGCAAAATAA	0.303													51	74					0	0	0	0	G	56188387	G	G	56188387	5	3	122	1	0	0	0	0	0	0	1	0	17588	927	32	2	880	2	ZBP1	20	56188387	Splice_Site	SNP	C	TCGA-CR-6472-01A-11D-1870-08	3989532	56188387	6837133	514	21961											
CDH26	60437	broad.mit.edu	37	chr20	58571732	58571732	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattttgtgcttgaacctaaGaggcatggatgctctgtatc	9	15	10	7	0	1	2	0	1	1	1	2	3	1	3	1	2	3	4	1	2	4	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:58571732G>A	uc002ybe.2	+	13	2235	c.1935G>A	c.(1933-1935)AAG>AAA	p.K645K	CDH26_uc002ybf.1_Silent_p.K225K|CDH26_uc010zzy.1_RNA|CDH26_uc002ybg.2_Silent_p.K159K|CDH26_uc002ybh.2_Intron|CDH26_uc002ybi.2_Intron	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	645	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TTGAACCTAAGAGGCATGGAT	0.453													75	125					0	0	0	0	A	58571732	A	A	58571732	2	1	122	1	0	0	0	0	0	0	0	1	3125	933	33	2		2	CDH26	20	58571732	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2383345	58571732	4453788	515	21962											
ARFGAP1	55738	broad.mit.edu	37	chr20	61907878	61907878	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtggaaggacattgagcttGagaagatgaaagctggtggg	13	8	17	3	0	0	4	0	3	0	2	0	7	0	6	0	4	2	2	0	4	3	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:61907878G>C	uc002yem.2	+	4	329	c.217G>C	c.(217-219)GAG>CAG	p.E73Q	ARFGAP1_uc011aas.1_Missense_Mutation_p.E20Q|ARFGAP1_uc011aat.1_5'UTR|ARFGAP1_uc002yel.2_Missense_Mutation_p.E73Q|ARFGAP1_uc002yen.2_Missense_Mutation_p.E73Q	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	73	Arf-GAP.				COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					CATTGAGCTTGAGAAGATGAA	0.522													22	31					0	0	0	0	C	61907878	C	C	61907878	3	2	122	1	0	0	0	0	1	0	0	0	849	1291	45	2	227	2	ARFGAP1	20	61907878	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	3336146	61907878	1117642	516	21963											
CHRNA4	1137	broad.mit.edu	37	chr20	61982264	61982264	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgctggtcgaaggggaagaAggtgacgtcgatgctgcagg	9	7	18	7	3	0	2	0	1	0	1	2	5	0	3	0	5	3	3	0	5	3	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:61982264A>C	uc002yes.2	-	5	677	c.499T>G	c.(499-501)TTC>GTC	p.F167V	CHRNA4_uc002yet.1_5'UTR|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Missense_Mutation_p.F96V|CHRNA4_uc002yev.1_5'UTR|CHRNA4_uc010gkf.1_5'UTR	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	167	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AAGGGGAAGAAGGTGACGTCG	0.607													33	53					0	0	0	0	C	61982264	C	C	61982264	3	2	122	1	0	0	0	0	1	0	0	0	3400	72	3	5	1392	5	CHRNA4	20	61982264	Missense_Mutation	SNP	A	TCGA-CR-6472-01A-11D-1870-08	74386	61982264	1043256	517	21964											
MYT1	4661	broad.mit.edu	37	chr20	62837064	62837064	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactgaggtgaaggacgcctCtgtttcggatgaatcggaag	10	9	14	8	3	1	3	0	3	1	0	3	6	1	6	1	4	0	1	1	4	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr20:62837064C>G	uc002yii.2	+	6	672	c.308C>G	c.(307-309)TCT>TGT	p.S103C	MYT1_uc002yih.2_Missense_Mutation_p.S103C|MYT1_uc002yij.2_5'Flank	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	103					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AAGGACGCCTCTGTTTCGGAT	0.597													6	13					0	0	0	0	G	62837064	G	G	62837064	3	3	122	1	0	0	0	0	1	0	0	0	10159	913	32	2	322	2	MYT1	20	62837064	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	854800	62837064	188456	518	21965											
RNF160	26046	broad.mit.edu	37	chr21	30359144	30359144	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcaatttcttcagctccttGaatagcaggaacatagccta	12	12	7	10	0	3	1	2	1	1	0	4	2	4	2	2	1	4	2	2	1	6	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr21:30359144G>C	uc002ymr.2	-	2	305	c.292C>G	c.(292-294)CAA>GAA	p.Q98E	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	52							ligase activity|zinc ion binding				0						TCAGCTCCTTGAATAGCAGGA	0.428													36	61					0	0	0	0	C	30359144	C	C	30359144	3	2	122	1	0	0	0	0	1	0	0	0	13520	1299	45	2	5262	2	RNF160	21	30359144	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08		30359144	17770751	519	21966											
TIAM1	7074	broad.mit.edu	37	chr21	32492803	32492803	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacagggcagcttgcttcttGagctgtgccatgcgggacgc	6	9	15	11	2	1	1	0	1	1	0	1	3	1	2	1	2	5	4	1	2	0	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr21:32492803G>C	uc002yow.1	-	29	5131	c.4659C>G	c.(4657-4659)CTC>CTG	p.L1553L	TIAM1_uc011adk.1_3'UTR|TIAM1_uc011adl.1_Silent_p.L1493L	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1553					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						CTTGCTTCTTGAGCTGTGCCA	0.597													33	36					0	0	0	0	C	32492803	C	C	32492803	2	2	122	1	0	0	0	0	0	0	0	1	15956	1277	45	2		2	TIAM1	21	32492803	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	2133659	32492803	15637092	520	21967											
TIAM1	7074	broad.mit.edu	37	chr21	32513499	32513499	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acagccccaaactcttcatgGattttctgcatctcattgat	10	14	5	12	0	4	1	2	1	3	0	5	2	4	2	2	1	3	1	2	1	1	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr21:32513499G>A	uc002yow.1	-	23	4183	c.3711C>T	c.(3709-3711)ATC>ATT	p.I1237I	TIAM1_uc011adk.1_Silent_p.I1237I|TIAM1_uc011adl.1_Silent_p.I1177I	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1237					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						ACTCTTCATGGATTTTCTGCA	0.463													28	38					0	0	0	0	A	32513499	A	A	32513499	2	1	122	1	0	0	0	0	0	0	0	1	15956	1164	41	2		2	TIAM1	21	32513499	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	20696	32513499	15616396	521	21968											
TIAM1	7074	broad.mit.edu	37	chr21	32513759	32513759	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgaggtacgactccagcgtgGatgagtgctgctgcttcggg	6	10	16	9	3	0	2	0	2	0	0	2	4	1	3	1	3	5	4	1	3	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr21:32513759G>A	uc002yow.1	-	22	4011	c.3539C>T	c.(3538-3540)TCC>TTC	p.S1180F	TIAM1_uc011adk.1_Missense_Mutation_p.S1180F|TIAM1_uc011adl.1_Missense_Mutation_p.S1120F	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1180	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						CTCCAGCGTGGATGAGTGCTG	0.577													43	91					0	0	0	0	A	32513759	A	A	32513759	3	1	122	1	0	0	0	0	1	0	0	0	15956	1174	41	2	1268	2	TIAM1	21	32513759	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	260	32513759	15616136	522	21969											
TIAM1	7074	broad.mit.edu	37	chr21	32589957	32589957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgctccttcgcttgctcgcgGatctggacatggcctgagta	5	12	12	12	3	1	1	0	1	1	0	4	3	2	3	2	3	2	4	2	3	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr21:32589957G>A	uc002yow.1	-	10	2526	c.2054C>T	c.(2053-2055)TCC>TTC	p.S685F	TIAM1_uc011adk.1_Missense_Mutation_p.S685F|TIAM1_uc011adl.1_Missense_Mutation_p.S685F|TIAM1_uc002yox.1_Missense_Mutation_p.S293F	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	685					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						CTTGCTCGCGGATCTGGACAT	0.542													42	75					0	0	0	0	A	32589957	A	A	32589957	3	1	122	1	0	0	0	0	1	0	0	0	15956	1174	41	2	2801	2	TIAM1	21	32589957	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	76198	32589957	15539938	523	21970											
IFNGR2	3460	broad.mit.edu	37	chr21	34787221	34787221	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcccagctgcccgctcctCagcacccgaagattcgcctg	6	9	8	18	3	1	1	1	0	0	1	4	2	3	1	5	0	3	3	5	0	1	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr21:34787221C>T	uc002yrp.3	+	2	748	c.100C>T	c.(100-102)CAG>TAG	p.Q34*	IFNGR2_uc002yrq.3_Nonsense_Mutation_p.Q53*|IFNGR2_uc010gma.2_5'UTR|IFNGR2_uc002yrr.3_5'UTR	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	34	Extracellular (Potential).|Fibronectin type-III 1.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	GCCCGCTCCTCAGCACCCGAA	0.393													15	16					0	0	0	0	T	34787221	T	T	34787221	4	4	122	1	0	0	0	0	0	1	0	0	7589	827	29	2	106	2	IFNGR2	21	34787221	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2197264	34787221	13342674	524	21971											
UMODL1	89766	broad.mit.edu	37	chr21	43508453	43508453	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccgtccaccacctgcactCagcccctgggaacgcctcca	8	5	7	21	2	1	0	1	0	0	0	3	1	3	1	8	1	3	1	8	1	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr21:43508453C>G	uc002zaf.1	+	5	653	c.653C>G	c.(652-654)TCA>TGA	p.S218*	UMODL1_uc002zad.1_Nonsense_Mutation_p.S146*|UMODL1_uc002zae.1_Nonsense_Mutation_p.S146*|UMODL1_uc002zag.1_Nonsense_Mutation_p.S218*|UMODL1_uc010gow.1_Nonsense_Mutation_p.S10*|UMODL1_uc002zai.1_5'UTR|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Intron|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Nonsense_Mutation_p.S10*	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	218	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CACCTGCACTCAGCCCCTGGG	0.602													21	7					0	0	0	0	G	43508453	G	G	43508453	4	3	122	1	0	0	0	0	0	1	0	0	17048	838	29	2	671	2	UMODL1	21	43508453	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	8721232	43508453	4621442	525	21972											
UBASH3A	53347	broad.mit.edu	37	chr21	43852254	43852254	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgctggtggttcgccacgggGagagagtggatcagatcttc	7	10	16	8	2	2	2	1	0	1	2	4	5	2	4	1	5	1	2	1	5	0	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr21:43852254G>A	uc002zbe.2	+	9	1249	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K	UBASH3A_uc002zbf.2_Missense_Mutation_p.E367K|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.E367K	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	405	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						TCGCCACGGGGAGAGAGTGGA	0.567													5	7					0	0	0	0	A	43852254	A	A	43852254	3	1	122	1	0	0	0	0	1	0	0	0	16907	1175	41	2	1247	2	UBASH3A	21	43852254	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	343801	43852254	4277641	526	21973											
C21orf70	85395	broad.mit.edu	37	chr21	46387037	46387037	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggggacctgcaccctctCagggatgccctgcccgagct	5	7	14	15	1	1	0	1	0	1	0	2	3	1	2	4	3	4	2	4	3	0	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr21:46387037C>A	uc002zgl.2	+	4	459	c.441C>A	c.(439-441)CTC>CTA	p.L147L	C21orf70_uc002zgm.2_Silent_p.L132L	NM_058190	NP_478070	Q9NSI2	CU070_HUMAN	hypothetical protein LOC85395	147											0				Colorectal(79;0.248)		TGCACCCTCTCAGGGATGCCC	0.677													10	29					0.00136819	0.00138582	1	0	A	46387037	A	A	46387037	2	1	122	1	0	0	0	0	0	0	0	1	2143	813	29	2		2	C21orf70	21	46387037	Silent	SNP	C	TCGA-CR-6472-01A-11D-1870-08	2534783	46387037	1742858	527	21974											
RGL4	266747	broad.mit.edu	37	chr22	24034855	24034855	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaccttttctccttttccaGatcctgctccacgtcctggg	4	15	7	15	1	1	2	0	1	1	1	6	2	5	2	6	1	1	1	6	1	0	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr22:24034855G>A	uc002zxn.2	+	3	1544	c.374_splice	c.e3-1	p.D125_splice	LOC91316_uc002zxh.3_RNA|LOC91316_uc002zxi.3_RNA|LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Splice_Site_p.D125_splice|RGL4_uc002zxp.1_Splice_Site|RGL4_uc002zxq.2_Splice_Site	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation						small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						TCCTTTTCCAGATCCTGCTCC	0.547													20	35					0	0	0	0	A	24034855	A	A	24034855	5	1	122	1	0	0	0	0	0	0	1	0	13344	956	33	2	383	2	RGL4	22	24034855	Splice_Site	SNP	G	TCGA-CR-6472-01A-11D-1870-08		24034855	27269711	528	21975											
PIWIL3	440822	broad.mit.edu	37	chr22	25150055	25150055	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtctgggcctgggcagaTgttctctttatgaaatcata	8	14	10	9	0	3	2	1	1	2	1	4	2	3	2	2	2	0	2	2	2	3	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr22:25150055T>G	uc003abd.1	-	8	1320	c.903A>C	c.(901-903)ACA>ACC	p.T301T	PIWIL3_uc011ajx.1_Silent_p.T192T|PIWIL3_uc011ajy.1_Silent_p.T192T|PIWIL3_uc010gut.1_Silent_p.T301T	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	301	PAZ.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						CCTGGGCAGATGTTCTCTTTA	0.388													36	73					0	0	0	0	G	25150055	G	G	25150055	2	3	122	1	0	0	0	0	0	0	0	1	12014	1451	51	5		5	PIWIL3	22	25150055	Silent	SNP	T	TCGA-CR-6472-01A-11D-1870-08	1115200	25150055	26154511	529	21976											
CRYBA4	1413	broad.mit.edu	37	chr22	27026412	27026412	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtggggctctcatgccccGaccttccaggtgcagagcat	7	8	13	13	1	1	1	1	0	1	1	3	3	2	1	4	3	3	3	4	3	0	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr22:27026412G>A	uc003acz.3	+	6	587	c.552G>A	c.(550-552)CCG>CCA	p.P184P		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	184	Beta/gamma crystallin 'Greek key' 4.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						CTCATGCCCCGACCTTCCAGG	0.597													27	28					0	0	0	0	A	27026412	A	A	27026412	2	1	122	1	0	0	0	0	0	0	0	1	3924	1045	37	1		1	CRYBA4	22	27026412	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1876357	27026412	24278154	530	21977											
MYH9	4627	broad.mit.edu	37	chr22	36684376	36684376	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgcgcctccaggtccttcagGtccatctccagcttcttccg	4	12	8	17	2	3	0	1	0	2	0	8	0	7	0	6	2	2	1	6	2	0	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr22:36684376G>A	uc003apg.2	-	34	5085	c.4854C>T	c.(4852-4854)GAC>GAT	p.D1618D		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1618	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GGTCCTTCAGGTCCATCTCCA	0.642			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				17	61					0	0	0	0	A	36684376	A	A	36684376	2	1	122	1	0	0	0	0	0	0	0	1	10095	1252	44	4		4	MYH9	22	36684376	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	9657964	36684376	14620190	531	21978											
EIF3D	8664	broad.mit.edu	37	chr22	36912642	36912642	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcaatatcatctccaagcttCcacctgcggtaactgcagca	11	10	6	14	1	3	0	2	0	1	0	5	0	4	0	3	1	5	4	3	1	4	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr22:36912642C>T	uc003apq.2	-	12	1205	c.1089G>A	c.(1087-1089)TGG>TGA	p.W363*	EIF3D_uc011amr.1_Nonsense_Mutation_p.W190*|EIF3D_uc003apr.2_Nonsense_Mutation_p.W363*|EIF3D_uc011ams.1_Nonsense_Mutation_p.W266*|EIF3D_uc011amt.1_Nonsense_Mutation_p.W314*	NM_003753	NP_003744	O15371	EIF3D_HUMAN	eukaryotic translation initiation factor 3	363						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			pancreas(1)	1						CTCCAAGCTTCCACCTGCGGT	0.512													95	172					0	0	0	0	T	36912642	T	T	36912642	4	4	122	1	0	0	0	0	0	1	0	0	5038	856	30	2	573	2	EIF3D	22	36912642	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	228266	36912642	14391924	532	21979											
ELFN2	114794	broad.mit.edu	37	chr22	37769912	37769912	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggccgagtccagcttgaGagcatcgatgcagttgttaa	11	9	13	8	2	0	2	0	1	0	2	2	5	1	2	2	1	3	5	2	1	1	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr22:37769912G>C	uc003asq.3	-	3	2449	c.1663C>G	c.(1663-1665)CTC>GTC	p.L555V		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	555	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					TCCAGCTTGAGAGCATCGATG	0.627													30	28					0	0	0	0	C	37769912	C	C	37769912	3	2	122	1	0	0	0	0	1	0	0	0	5082	942	33	2	803	2	ELFN2	22	37769912	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	857270	37769912	13534654	533	21980											
XPNPEP3	63929	broad.mit.edu	37	chr22	41253202	41253202	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtaatgccttggctgctctCagcccccaagctggttcccg	5	10	10	16	2	1	0	1	0	1	0	3	0	2	0	4	2	4	5	4	2	2	3			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr22:41253202C>A	uc003azh.2	+	1	109	c.17C>A	c.(16-18)TCA>TAA	p.S6*	XPNPEP3_uc011aox.1_Nonsense_Mutation_p.S6*|XPNPEP3_uc003azi.2_5'UTR|ST13_uc003aze.2_5'Flank|ST13_uc011aow.1_5'Flank|XPNPEP3_uc003azg.1_RNA|XPNPEP3_uc003azf.1_RNA	NM_022098	NP_071381	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3,	6					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity				0						TGGCTGCTCTCAGCCCCCAAG	0.632													8	4					0.000442599	0.000452675	1	0	A	41253202	A	A	41253202	4	1	122	1	0	0	0	0	0	1	0	0	17512	838	29	2	19	2	XPNPEP3	22	41253202	Nonsense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	3483290	41253202	10051364	534	21981											
TNFRSF13C	115650	broad.mit.edu	37	chr22	42322147	42322147	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcggaggacgcgccgcGaagccgccgctgtcgccgcc	4	4	15	18	9	1	0	0	0	1	0	2	3	1	2	5	2	2	1	5	2	1	0			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr22:42322147G>T	uc003bbl.2	-	2	369	c.325C>A	c.(325-327)CGC>AGC	p.R109S	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|TNFRSF13C_uc010gyp.1_Missense_Mutation_p.R110S	NM_052945	NP_443177	Q96RJ3	TR13C_HUMAN	BAFF receptor	109	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						GACGCGCCGCGAAGCCGCCGC	0.602													10	12					6.40141e-05	6.5685e-05	1	0	T	42322147	T	T	42322147	3	4	122	1	0	0	0	0	1	0	0	0	16354	1058	37	3	237	3	TNFRSF13C	22	42322147	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	1068945	42322147	8982419	535	21982											
MPPED1	758	broad.mit.edu	37	chr22	43831044	43831044	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cactcgaggacggaccccatCcagatgccgtacggcgacgt	9	5	12	15	6	0	1	0	0	0	1	2	5	1	3	4	3	2	1	4	3	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr22:43831044C>G	uc011apv.1	+	3	538	c.315C>G	c.(313-315)ATC>ATG	p.I105M	MPPED1_uc011apw.1_Translation_Start_Site|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Missense_Mutation_p.I105M|MPPED1_uc011apz.1_Missense_Mutation_p.I138M	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	105							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				CGGACCCCATCCAGATGCCGT	0.642													49	36					0	0	0	0	G	43831044	G	G	43831044	3	3	122	1	0	0	0	0	1	0	0	0	9794	845	30	2	321	2	MPPED1	22	43831044	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	1508897	43831044	7473522	536	21983											
PANX2	56666	broad.mit.edu	37	chr22	50616191	50616191	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaacatcctggccatgttCtgcaacgagaaccgcgacca	12	7	8	14	3	2	1	1	0	1	1	3	3	3	1	4	1	4	2	4	1	3	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chr22:50616191C>G	uc003bjn.3	+	2	1050	c.1050C>G	c.(1048-1050)TTC>TTG	p.F350L	PANX2_uc003bjp.3_Missense_Mutation_p.F216L|PANX2_uc003bjo.3_Missense_Mutation_p.F350L	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	350	Cytoplasmic (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		TGGCCATGTTCTGCAACGAGA	0.587													30	16					0	0	0	0	G	50616191	G	G	50616191	3	3	122	1	0	0	0	0	1	0	0	0	11475	912	32	2	1056	2	PANX2	22	50616191	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	6785147	50616191	688375	537	21984											
ARHGAP6	395	broad.mit.edu	37	chrX	11204461	11204461	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctttttcctttttactttGagcctcagcaggcaaggaaa	9	14	9	9	0	1	1	1	1	0	0	2	2	2	2	2	3	3	3	2	3	3	6			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chrX:11204461G>C	uc004cup.1	-	5	2041	c.1168C>G	c.(1168-1170)CAA>GAA	p.Q390E	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.Q390E|ARHGAP6_uc004cum.1_Missense_Mutation_p.Q187E|ARHGAP6_uc004cun.1_Missense_Mutation_p.Q210E|ARHGAP6_uc010neb.1_Missense_Mutation_p.Q212E|ARHGAP6_uc011mif.1_Missense_Mutation_p.Q187E	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	390					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						TTTTTACTTTGAGCCTCAGCA	0.453													89	32					0	0	0	0	C	11204461	C	C	11204461	3	2	122	1	0	0	0	0	1	0	0	0	887	1299	45	2	1914	2	ARHGAP6	23	11204461	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08		11204461	144066099	538	21985											
ATP6AP2	10159	broad.mit.edu	37	chrX	40456555	40456555	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccattcactccttattttctGaggaaactcctgttgttttg	7	18	6	10	0	2	1	1	1	1	0	4	2	4	2	3	1	1	2	3	1	2	7			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chrX:40456555G>C	uc004det.2	+	4	457	c.355G>C	c.(355-357)GAG>CAG	p.E119Q	ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_Missense_Mutation_p.E43Q|ATP6AP2_uc011mkm.1_Intron|ATP6AP2_uc011mkn.1_Intron|ATP6AP2_uc004deu.1_5'Flank	NM_005765	NP_005756	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory	119	Extracellular (Potential).				angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0						CTTATTTTCTGAGGAAACTCC	0.323													33	19					0	0	0	0	C	40456555	C	C	40456555	3	2	122	1	0	0	0	0	1	0	0	0	1169	1291	45	2	369	2	ATP6AP2	23	40456555	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	29252094	40456555	114814005	539	21986											
CXorf38	159013	broad.mit.edu	37	chrX	40496291	40496291	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagtatactgccacaatctCtgggatgttcttgaattcat	10	14	9	8	0	3	1	1	1	2	0	4	3	3	3	1	2	2	2	1	2	4	5			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chrX:40496291C>G	uc004dew.2	-	4	594	c.589G>C	c.(589-591)GAG>CAG	p.E197Q	CXorf38_uc011mko.1_Missense_Mutation_p.E112Q|CXorf38_uc004dev.1_Missense_Mutation_p.E78Q|CXorf38_uc010nhd.2_RNA	NM_144970	NP_659407	Q8TB03	CX038_HUMAN	hypothetical protein LOC159013	197										ovary(1)	1						GCCACAATCTCTGGGATGTTC	0.368													30	11					0	0	0	0	G	40496291	G	G	40496291	3	3	122	1	0	0	0	0	1	0	0	0	4124	922	32	2	382	2	CXorf38	23	40496291	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	39736	40496291	114774269	540	21987											
HUWE1	10075	broad.mit.edu	37	chrX	53654387	53654387	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tatcagtttccatttcctctCcttcttgtgtagtattgggt	5	20	7	9	0	3	0	1	0	2	0	6	0	5	0	3	1	0	3	3	1	3	8			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chrX:53654387C>T	uc004dsp.2	-	17	1865	c.1463G>A	c.(1462-1464)GGA>GAA	p.G488E		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	488					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CATTTCCTCTCCTTCTTGTGT	0.378													40	18					0	0	0	0	T	53654387	T	T	53654387	3	4	122	1	0	0	0	0	1	0	0	0	7500	855	30	2	11933	2	HUWE1	23	53654387	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	13158096	53654387	101616173	541	21988											
ARR3	407	broad.mit.edu	37	chrX	69496305	69496305	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgaccaacctgccctgttCtgtgacactgcagccaggtc	7	9	11	14	0	1	2	0	2	1	0	2	2	1	2	4	2	4	2	4	2	1	1			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chrX:69496305C>G	uc004dyb.2	+	7	436	c.368C>G	c.(367-369)TCT>TGT	p.S123C	ARR3_uc004dya.2_Missense_Mutation_p.S123C	NM_004312	NP_004303	P36575	ARRC_HUMAN	arrestin 3, retinal (X-arrestin)	123					signal transduction|visual perception	cytoplasm|soluble fraction				large_intestine(2)|ovary(2)	4						CTGCCCTGTTCTGTGACACTG	0.478													27	8					0	0	0	0	G	69496305	G	G	69496305	3	3	122	1	0	0	0	0	1	0	0	0	981	913	32	2	390	2	ARR3	23	69496305	Missense_Mutation	SNP	C	TCGA-CR-6472-01A-11D-1870-08	15841918	69496305	85774255	542	21989											
GPR112	139378	broad.mit.edu	37	chrX	135430993	135430993	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaacagtcatcacaagcaGatgaggctacaactttgggc	13	8	9	11	0	3	2	3	1	0	1	3	2	3	2	0	2	4	2	0	2	4	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chrX:135430993G>A	uc004ezu.1	+	6	5419	c.5128G>A	c.(5128-5130)GAT>AAT	p.D1710N	GPR112_uc010nsb.1_Missense_Mutation_p.D1505N|GPR112_uc010nsc.1_Missense_Mutation_p.D1477N	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1710	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ATCACAAGCAGATGAGGCTAC	0.438													83	25					0	0	0	0	A	135430993	A	A	135430993	3	1	122	1	0	0	0	0	1	0	0	0	6667	942	33	2	5138	2	GPR112	23	135430993	Missense_Mutation	SNP	G	TCGA-CR-6472-01A-11D-1870-08	65934688	135430993	19839567	543	21990											
MECP2	4204	broad.mit.edu	37	chrX	153296808	153296808	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccctctcccagttaccgtGaagtcaaaatcattagggtc	10	11	7	13	1	3	1	2	1	1	0	6	1	4	1	3	1	1	1	3	1	5	2			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chrX:153296808G>A	uc004fjv.2	-	4	697	c.471C>T	c.(469-471)TTC>TTT	p.F157F	MECP2_uc004fjw.2_Silent_p.F169F	NM_004992	NP_004983	P51608	MECP2_HUMAN	methyl CpG binding protein 2 isoform 1	157	MBD.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGTTACCGTGAAGTCAAAAT	0.562													53	12					0	0	0	0	A	153296808	A	A	153296808	2	1	122	1	0	0	0	0	0	0	0	1	9476	1281	45	2		2	MECP2	23	153296808	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	17865815	153296808	1973752	544	21991											
FLNA	2316	broad.mit.edu	37	chrX	153580937	153580937	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaccagggattttcaggctGaggtcacaatgactaccaac	12	9	9	11	0	2	2	2	2	0	0	2	3	2	3	2	3	3	1	2	3	4	4			TCGA-CR-6472-01A-11D-1870-08	TCGA-CR-6472-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	52f12c71-2473-4411-aad6-318a3496e82c	f7bf4ee7-86c8-4f5c-85d7-7ff4c2e3443d	g.chrX:153580937G>A	uc004fkk.2	-	40	6735	c.6486C>T	c.(6484-6486)CTC>CTT	p.L2162L	FLNA_uc004fki.2_Silent_p.L205L|FLNA_uc011mzn.1_Silent_p.L295L|FLNA_uc010nuu.1_Silent_p.L2154L	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2162	Filamin 20.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTTTCAGGCTGAGGTCACAAT	0.637													26	14					0	0	0	0	A	153580937	A	A	153580937	2	1	122	1	0	0	0	0	0	0	0	1	5965	1277	45	2		2	FLNA	23	153580937	Silent	SNP	G	TCGA-CR-6472-01A-11D-1870-08	284129	153580937	1689623	545	21992											
C1orf168	199920	broad.mit.edu	37	chr1	57252852	57252852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagcatgtacttacctctCtggagacagggagccctctt	9	10	11	11	0	2	1	0	0	2	1	3	4	2	3	2	3	4	2	2	3	2	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr1:57252852C>T	uc001cym.3	-	4	1355	c.949G>A	c.(949-951)GAG>AAG	p.E317K	C1orf168_uc009vzu.1_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	317										ovary(3)|skin(2)	5						ACTTACCTCTCTGGAGACAGG	0.488													35	42					0	0	0	0	T	57252852	T	T	57252852	3	4	123	1	0	0	0	0	1	0	0	0	2021	922	32	2	1305	2	C1orf168	1	57252852	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08		57252852	191997769	1	21993											
TCHH	7062	broad.mit.edu	37	chr1	152080007	152080007	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttatctccccgacttggcGgtgcctctgttcctccttct	2	17	7	15	2	3	0	0	0	3	0	6	1	5	0	5	2	1	1	5	2	1	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr1:152080007G>A	uc001ezp.2	-	2	5686	c.5686C>T	c.(5686-5688)CGC>TGC	p.R1896C	TCHH_uc009wne.1_Missense_Mutation_p.R1896C	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1896					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGACTTGGCGGTGCCTCTGT	0.582													72	63					0	0	0	0	A	152080007	A	A	152080007	3	1	123	1	0	0	0	0	1	0	0	0	15766	1116	39	1	149	1	TCHH	1	152080007	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	94827155	152080007	97170614	2	21994											
RPTN	126638	broad.mit.edu	37	chr1	152128845	152128845	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agattgttgtgtatgtctttCagactgaccataatgagaat	12	15	9	5	0	2	4	1	2	1	3	2	5	2	4	1	0	0	2	1	0	3	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr1:152128845C>G	uc001ezs.1	-	3	795	c.730G>C	c.(730-732)GAA>CAA	p.E244Q		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	244	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						GTATGTCTTTCAGACTGACCA	0.423													100	115					0	0	0	0	G	152128845	G	G	152128845	3	3	123	1	0	0	0	0	1	0	0	0	13729	835	29	2	1628	2	RPTN	1	152128845	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	48838	152128845	97121776	3	21995											
FLG	2312	broad.mit.edu	37	chr1	152285143	152285143	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgactaccactggaccctCggtgtccactgtctctgact	6	11	8	16	1	1	2	0	2	1	0	4	3	2	3	4	2	1	0	4	2	1	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr1:152285143C>T	uc001ezu.1	-	3	2255	c.2219G>A	c.(2218-2220)CGA>CAA	p.R740Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	740	Filaggrin 4.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTGGACCCTCGGTGTCCACT	0.577									Ichthyosis				250	325					0	0	0	0	T	152285143	T	T	152285143	3	4	123	1	0	0	0	0	1	0	0	0	5954	884	31	1	9970	1	FLG	1	152285143	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	156298	152285143	96965478	4	21996											
C1orf9	51430	broad.mit.edu	37	chr1	172558719	172558719	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtctgaaacaatagtgccAccaataaatacagccactgt	15	9	6	11	0	1	1	0	1	1	0	1	1	1	1	3	0	4	0	3	0	7	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr1:172558719A>G	uc001giq.3	+	18	2794	c.2478A>G	c.(2476-2478)CCA>CCG	p.P826P	C1orf9_uc010pmm.1_Silent_p.P826P|C1orf9_uc009wwd.2_Silent_p.P782P|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	826					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		CAATAGTGCCACCAATAAATA	0.348													4	20					0	0	0	0	G	172558719	G	G	172558719	2	3	123	1	0	0	0	0	0	0	0	1	2077	146	6	5		5	C1orf9	1	172558719	Silent	SNP	A	TCGA-CR-6473-01A-11D-1870-08	20273576	172558719	76691902	5	21997											
ASPM	259266	broad.mit.edu	37	chr1	197069707	197069707	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacagaaatgctctgtagtGattttgtaaaaccactgctg	13	12	9	7	0	1	3	0	1	1	2	1	3	1	3	1	0	3	4	1	0	4	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr1:197069707G>A	uc001gtu.2	-	18	8931	c.8674C>T	c.(8674-8676)CAC>TAC	p.H2892Y	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.H740Y	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2892					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GCTCTGTAGTGATTTTGTAAA	0.343													24	26					0	0	0	0	A	197069707	A	A	197069707	3	1	123	1	0	0	0	0	1	0	0	0	1058	1290	45	2	1803	2	ASPM	1	197069707	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	24510988	197069707	52180914	6	21998											
TPO	7173	broad.mit.edu	37	chr2	1459985	1459985	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaccacagagcaccagcaaAgctgccttcgggggaggggc	11	3	14	13	1	0	1	0	0	0	1	1	2	0	2	3	4	4	3	3	4	1	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:1459985A>G	uc002qww.2	+	7	841	c.750A>G	c.(748-750)AAA>AAG	p.K250K	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Silent_p.K250K|TPO_uc002qwr.2_Silent_p.K250K|TPO_uc002qwx.2_Silent_p.K250K|TPO_uc010yio.1_Silent_p.K250K|TPO_uc010yip.1_Silent_p.K250K	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	250	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCACCAGCAAAGCTGCCTTCG	0.483													11	20					0	0	0	0	G	1459985	G	G	1459985	2	3	123	1	0	0	0	0	0	0	0	1	16477	69	3	5		5	TPO	2	1459985	Silent	SNP	A	TCGA-CR-6473-01A-11D-1870-08		1459985	241739388	7	21999											
PLEKHH2	130271	broad.mit.edu	37	chr2	43871918	43871918	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaagcaagcaagatacgaGagcttttagcagagaaggta	16	8	11	6	1	1	3	1	0	0	3	1	5	1	3	0	1	5	5	0	1	7	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:43871918G>A	uc010yny.1	+	2	189	c.106G>A	c.(106-108)GAG>AAG	p.E36K	PLEKHH2_uc002rte.3_Missense_Mutation_p.E36K|PLEKHH2_uc002rtf.3_Missense_Mutation_p.E36K	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	36	Potential.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CAAGATACGAGAGCTTTTAGC	0.398													20	27					0	0	0	0	A	43871918	A	A	43871918	3	1	123	1	0	0	0	0	1	0	0	0	12132	943	33	2	108	2	PLEKHH2	2	43871918	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	42411933	43871918	199327455	8	22000											
KIAA1310	55683	broad.mit.edu	37	chr2	97274403	97274403	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacacactggagagatccTgagtaaggtgagaaggtcaa	14	7	14	6	0	1	3	1	2	0	2	2	7	2	5	1	4	0	1	1	4	3	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:97274403T>C	uc002swn.3	-	14	1731	c.1585_splice	c.e14-1	p.D529_splice	KIAA1310_uc002swh.3_Splice_Site_p.D417_splice|KIAA1310_uc002swi.3_Splice_Site_p.D430_splice|KIAA1310_uc002swj.3_Splice_Site|KIAA1310_uc002swk.3_Splice_Site_p.D442_splice|KIAA1310_uc010fhz.2_Splice_Site_p.D323_splice|KIAA1310_uc002swl.3_Splice_Site_p.D430_splice|KIAA1310_uc002swm.3_Splice_Site|KIAA1310_uc010yur.1_Splice_Site_p.D323_splice|KIAA1310_uc002swp.1_Splice_Site_p.D430_splice	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a												0						GGAGAGATCCTGAGTAAGGTG	0.522													25	35					0	0	0	0	C	97274403	C	C	97274403	5	2	123	1	0	0	0	0	0	0	1	0	8261	1594	55	5	1085	5	KIAA1310	2	97274403	Splice_Site	SNP	T	TCGA-CR-6473-01A-11D-1870-08	53402485	97274403	145924970	9	22001											
FAM178B	51252	broad.mit.edu	37	chr2	97543732	97543732	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggggctctcccggatctgCgtgctgatgtggcggtccaa	4	10	16	11	3	2	1	0	1	2	0	4	2	3	2	2	5	2	2	2	5	1	0	rs145363262		TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:97543732C>T	uc002sxl.3	-	16	2153	c.1806G>A	c.(1804-1806)ACG>ACA	p.T602T	FAM178B_uc002sxi.3_Silent_p.T93T|FAM178B_uc002sxk.3_Silent_p.T317T|FAM178B_uc002sxj.3_Silent_p.T74T	NM_001122646	NP_001116118	Q8IXR5	F178B_HUMAN	hypothetical protein LOC51252 isoform A	782											0						CCCGGATCTGCGTGCTGATGT	0.647													15	25					0	0	0	0	T	97543732	T	T	97543732	2	4	123	1	0	0	0	0	0	0	0	1	5532	755	27	1		1	FAM178B	2	97543732	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	269329	97543732	145655641	10	22002											
TSGA10	80705	broad.mit.edu	37	chr2	99721848	99721848	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactgtacactccagctcctCtatcctttgttccaggtgag	8	13	7	13	0	1	1	0	1	1	0	5	1	5	1	4	1	3	3	4	1	3	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:99721848C>G	uc002szg.3	-	7	1061	c.433G>C	c.(433-435)GAG>CAG	p.E145Q	TSGA10_uc002szh.3_Missense_Mutation_p.E145Q|TSGA10_uc002szi.3_Missense_Mutation_p.E145Q|TSGA10_uc010fin.1_Missense_Mutation_p.E145Q|TSGA10_uc010yvn.1_Missense_Mutation_p.E145Q	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	145					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						TCCAGCTCCTCTATCCTTTGT	0.338													25	42					0	0	0	0	G	99721848	G	G	99721848	3	3	123	1	0	0	0	0	1	0	0	0	16684	922	32	2	1715	2	TSGA10	2	99721848	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	2178116	99721848	143477525	11	22003											
R3HDM1	23518	broad.mit.edu	37	chr2	136399147	136399147	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagggtcatctacaggctctCtttctcacatccagcagcct	8	12	7	14	0	4	0	2	0	3	0	7	0	5	0	2	2	3	2	2	2	2	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:136399147C>G	uc002tuo.2	+	15	1631	c.1261C>G	c.(1261-1263)CTT>GTT	p.L421V	R3HDM1_uc010fni.2_Missense_Mutation_p.L419V|R3HDM1_uc002tup.2_Missense_Mutation_p.L365V|R3HDM1_uc010zbh.1_Intron	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	421							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		TACAGGCTCTCTTTCTCACAT	0.438													46	65					0	0	0	0	G	136399147	G	G	136399147	3	3	123	1	0	0	0	0	1	0	0	0	12952	913	32	2	1311	2	R3HDM1	2	136399147	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	36677299	136399147	106800226	12	22004											
SCN9A	6335	broad.mit.edu	37	chr2	167143021	167143021	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttctttcttctgtttcttCtttctttagcacttttagag	4	25	4	8	0	6	1	0	0	6	1	6	1	6	1	0	0	1	2	0	0	2	11			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:167143021C>T	uc010fpl.2	-	11	1768	c.1427G>A	c.(1426-1428)AGA>AAA	p.R476K	uc002udp.2_Intron|SCN9A_uc002udr.1_Missense_Mutation_p.R347K|SCN9A_uc002uds.1_Missense_Mutation_p.R347K|SCN9A_uc002udt.1_Missense_Mutation_p.R347K	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	476						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TCTGTTTCTTCTTTCTTTAGC	0.408													25	29					0	0	0	0	T	167143021	T	T	167143021	3	4	123	1	0	0	0	0	1	0	0	0	13990	913	32	2	4574	2	SCN9A	2	167143021	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	30743874	167143021	76056352	13	22005											
ZNF804A	91752	broad.mit.edu	37	chr2	185801739	185801740	+	Frame_Shift_Ins	INS	-	A	A																															tccagtagttgtgattctggINSaaaaaatgagaacacaggtc																										TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:185801739_185801740insA	uc002uph.2	+	4	2210_2211	c.1616_1617insA	c.(1615-1617)GGAfs	p.G539fs		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	539						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TGTGATTCTGGAAAAAATGAGA	0.347													---	---	---								A	185801740	A	A	185801739	7	5	123	1	0	1	1	0	0	0	0	0	18237	1174	41	0	1630	0	ZNF804A	2	185801739	Frame_Shift_Ins	INS	-	TCGA-CR-6473-01A-11D-1870-08	18658718	185801739	57397634	14	22006											
DNAH7	56171	broad.mit.edu	37	chr2	196602680	196602680	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acataacagtgctacacctcGtccaatccagtgttccttgg	10	11	7	13	1	0	0	0	0	0	0	4	0	3	0	4	1	3	2	4	1	3	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:196602680G>A	uc002utj.3	-	65	12141	c.12040C>T	c.(12040-12042)CGA>TGA	p.R4014*	DNAH7_uc002uti.3_Nonsense_Mutation_p.R497*	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	4014					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GCTACACCTCGTCCAATCCAG	0.433													21	24					0	0	0	0	A	196602680	A	A	196602680	4	1	123	1	0	0	0	0	0	1	0	0	4628	1153	40	1	38	1	DNAH7	2	196602680	Nonsense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	10800941	196602680	46596693	15	22007											
ALS2CR11	151254	broad.mit.edu	37	chr2	202430560	202430560	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcaggtctggggataagaatGctggatattctactgtctgt	9	14	12	6	0	4	1	1	0	3	1	4	3	4	3	0	4	2	1	0	4	4	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:202430560G>A	uc002uye.2	-	9	917	c.869C>T	c.(868-870)GCA>GTA	p.A290V	ALS2CR11_uc002uyf.2_Missense_Mutation_p.A290V|ALS2CR11_uc010fti.2_Missense_Mutation_p.A290V	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	290										large_intestine(1)|ovary(1)|skin(1)	3						GGATAAGAATGCTGGATATTC	0.393													7	17					0	0	0	0	A	202430560	A	A	202430560	3	1	123	1	0	0	0	0	1	0	0	0	552	1319	46	4	4772	4	ALS2CR11	2	202430560	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	5827880	202430560	40768813	16	22008											
BCS1L	617	broad.mit.edu	37	chr2	219527690	219527690	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtggcttccaccgaggcccGcatcgtgttcatgaccacca	7	9	10	15	3	1	1	1	1	0	0	3	2	2	1	5	2	0	3	5	2	0	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:219527690G>A	uc002vio.2	+	7	1392	c.974G>A	c.(973-975)CGC>CAC	p.R325H	BCS1L_uc002vip.2_Missense_Mutation_p.R325H|BCS1L_uc002viq.2_Missense_Mutation_p.R325H|BCS1L_uc010fvu.2_Missense_Mutation_p.R325H|BCS1L_uc010fvv.2_Missense_Mutation_p.R325H|BCS1L_uc002vir.2_Missense_Mutation_p.R325H|BCS1L_uc002vis.2_Missense_Mutation_p.R325H	NM_004328	NP_004319	Q9Y276	BCS1_HUMAN	BCS1-like	325	Mitochondrial matrix (Potential).				mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACCGAGGCCCGCATCGTGTTC	0.582													4	96					0	0	0	0	A	219527690	A	A	219527690	3	1	123	1	0	0	0	0	1	0	0	0	1391	1087	38	1	996	1	BCS1L	2	219527690	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	17097130	219527690	23671683	17	22009											
ACCN4	55515	broad.mit.edu	37	chr2	220396543	220396543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcggagctcgctgcccagcCgggcagggggcatgggcagt	5	4	19	13	4	0	0	0	0	0	0	1	1	0	1	2	5	3	5	2	5	0	0			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr2:220396543C>T	uc002vma.2	+	2	1041	c.1027C>T	c.(1027-1029)CGG>TGG	p.R343W	ACCN4_uc010fwi.1_Missense_Mutation_p.R343W|ACCN4_uc010fwj.1_Missense_Mutation_p.R343W|ACCN4_uc002vly.1_Missense_Mutation_p.R343W|ACCN4_uc002vlz.2_Missense_Mutation_p.R343W|ACCN4_uc002vmb.2_5'UTR	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	343	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		GCTGCCCAGCCGGGCAGGGGG	0.627													33	55					0	0	0	0	T	220396543	T	T	220396543	3	4	123	1	0	0	0	0	1	0	0	0	131	643	23	1	1033	1	ACCN4	2	220396543	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	868853	220396543	22802830	18	22010											
TTLL3	26140	broad.mit.edu	37	chr3	9877030	9877030	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctagggaagcccctgcttCgattccccactgcccttgtc	6	10	9	16	1	0	0	0	0	0	0	3	2	1	1	5	1	4	2	5	1	2	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:9877030C>T	uc003btg.2	+	13	2392	c.2176C>T	c.(2176-2178)CGA>TGA	p.R726*	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_3'UTR|TTLL3_uc003btf.3_3'UTR|TTLL3_uc003bth.3_3'UTR|TTLL3_uc011atj.1_3'UTR|TTLL3_uc003btj.3_3'UTR|TTLL3_uc003bti.3_3'UTR	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	726					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					GCCCCTGCTTCGATTCCCCAC	0.547													45	12					0	0	0	0	T	9877030	T	T	9877030	4	4	123	1	0	0	0	0	0	1	0	0	16796	876	31	1	2222	1	TTLL3	3	9877030	Nonsense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08		9877030	188145400	19	22011											
SATB1	6304	broad.mit.edu	37	chr3	18391090	18391090	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgccgtggggggagccgagGgcctgtctgtggctgctgct	2	10	19	10	2	1	0	0	0	1	0	1	2	1	1	3	5	4	3	3	5	0	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:18391090G>T	uc003cbh.2	-	11	3599	c.1864C>A	c.(1864-1866)CCT>ACT	p.P622T	SATB1_uc003cbi.2_Missense_Mutation_p.P654T|SATB1_uc003cbj.2_Missense_Mutation_p.P622T	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	622					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						GGGAGCCGAGGGCCTGTCTGT	0.468													22	4					2.70639e-06	2.89669e-06	1	0	T	18391090	T	T	18391090	3	4	123	1	0	0	0	0	1	0	0	0	13918	1232	43	4	431	4	SATB1	3	18391090	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	8514060	18391090	179631340	20	22012											
ENTPD3	956	broad.mit.edu	37	chr3	40457535	40457535	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctatggccggaatgaggctGagaagaagtttctggcaatg	11	9	15	6	1	1	3	0	2	1	2	1	5	1	4	1	4	0	4	1	4	5	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:40457535G>T	uc003ckd.3	+	7	894	c.802G>T	c.(802-804)GAG>TAG	p.E268*	ENTPD3_uc010hhy.2_Nonsense_Mutation_p.E268*|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	268	Extracellular (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		GAATGAGGCTGAGAAGAAGTT	0.552													15	5					4.14922e-12	4.54754e-12	1	0	T	40457535	T	T	40457535	4	4	123	1	0	0	0	0	0	1	0	0	5164	1291	45	2	824	2	ENTPD3	3	40457535	Nonsense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	22066445	40457535	157564895	21	22013											
USP19	10869	broad.mit.edu	37	chr3	49149394	49149394	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgggcataagtgaggcgtgaGgcaggtacactgaccaggaa	12	5	16	8	2	0	3	0	3	0	0	0	4	0	4	1	5	1	3	1	5	3	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:49149394G>A	uc003cwd.1	-	19	2705	c.2544C>T	c.(2542-2544)GCC>GCT	p.A848A	USP19_uc003cwa.2_Silent_p.A656A|USP19_uc003cvz.3_Silent_p.A951A|USP19_uc011bcg.1_Silent_p.A939A|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_Silent_p.A606A|USP19_uc011bch.1_Silent_p.A949A	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	848	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGAGGCGTGAGGCAGGTACAC	0.607													14	7					0	0	0	0	A	49149394	A	A	49149394	2	1	123	1	0	0	0	0	0	0	0	1	17118	987	35	4		4	USP19	3	49149394	Silent	SNP	G	TCGA-CR-6473-01A-11D-1870-08	8691859	49149394	148873036	22	22014											
GNL3	26354	broad.mit.edu	37	chr3	52720819	52720819	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtaaacgcatgacctgccaTaagcggtataaaatccaaaa	18	7	7	9	2	0	1	0	1	0	0	1	1	1	1	3	1	3	3	3	1	8	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:52720819T>C	uc003dfd.2	+	2	221	c.48T>C	c.(46-48)CAT>CAC	p.H16H	PBRM1_uc003dey.2_5'Flank|GNL3_uc011beh.1_RNA|GNL3_uc003dfe.2_Silent_p.H4H|GNL3_uc003dff.2_Silent_p.H4H|SNORD19_uc003dfg.1_5'Flank	NM_014366	NP_055181	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3	16	Basic (By similarity).				regulation of cell proliferation	nucleolus	GTP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		TGACCTGCCATAAGCGGTATA	0.398													18	7					0	0	0	0	C	52720819	C	C	52720819	2	2	123	1	0	0	0	0	0	0	0	1	6574	1403	49	5		5	GNL3	3	52720819	Silent	SNP	T	TCGA-CR-6473-01A-11D-1870-08	3571425	52720819	145301611	23	22015											
ITIH1	3697	broad.mit.edu	37	chr3	52825552	52825552	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcaatttttccaccccatCggttttgaagtgtctgacat	8	14	9	10	1	1	2	0	2	1	0	3	2	2	2	3	2	0	2	3	2	2	4	rs143276781	byFrequency	TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:52825552C>T	uc003dfs.2	+	21	2538	c.2514C>T	c.(2512-2514)ATC>ATT	p.I838I	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Silent_p.I439I|ITIH1_uc010hmo.1_Silent_p.I392I|ITIH1_uc003dfu.2_Silent_p.I204I	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	838	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TCCACCCCATCGGTTTTGAAG	0.597													21	4					0	0	0	0	T	52825552	T	T	52825552	2	4	123	1	0	0	0	0	0	0	0	1	7942	874	31	1		1	ITIH1	3	52825552	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	104733	52825552	145196878	24	22016											
DCP1A	55802	broad.mit.edu	37	chr3	53376252	53376252	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggttcaactagattgtgcaTatttagtcgattcacaatgg	11	15	9	6	1	2	1	2	0	0	1	3	2	2	1	0	2	2	2	0	2	5	7			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:53376252T>C	uc003dgs.3	-	3	316	c.223A>G	c.(223-225)ATG>GTG	p.M75V	DCP1A_uc003dgt.3_RNA	NM_018403	NP_060873	Q9NPI6	DCP1A_HUMAN	DCP1 decapping enzyme homolog A	75					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		AGATTGTGCATATTTAGTCGA	0.318													7	1					0	0	0	0	C	53376252	C	C	53376252	3	2	123	1	0	0	0	0	1	0	0	0	4315	1406	49	5	1557	5	DCP1A	3	53376252	Missense_Mutation	SNP	T	TCGA-CR-6473-01A-11D-1870-08	550700	53376252	144646178	25	22017											
PHLDB2	90102	broad.mit.edu	37	chr3	111637948	111637948	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtataagtgaagaacagagAtctcaggagttggctgcaat	14	9	13	5	0	1	3	1	1	1	2	2	5	1	4	0	3	2	4	0	3	5	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:111637948A>T	uc010hqa.2	+	4	2160	c.1749A>T	c.(1747-1749)AGA>AGT	p.R583S	PHLDB2_uc003dyc.2_Missense_Mutation_p.R610S|PHLDB2_uc003dyd.2_Missense_Mutation_p.R583S|PHLDB2_uc003dyg.2_Missense_Mutation_p.R583S|PHLDB2_uc003dyh.2_Missense_Mutation_p.R583S|PHLDB2_uc003dyi.2_Missense_Mutation_p.R169S	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	583						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						AAGAACAGAGATCTCAGGAGT	0.403													53	157					0	0	0	0	T	111637948	T	T	111637948	3	4	123	1	0	0	0	0	1	0	0	0	11907	330	12	5	1844	5	PHLDB2	3	111637948	Missense_Mutation	SNP	A	TCGA-CR-6473-01A-11D-1870-08	58261696	111637948	86384482	26	22018											
KALRN	8997	broad.mit.edu	37	chr3	124053163	124053163	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctgcagcggcccctgagcCctgggaactccgaatccctc	6	7	11	17	2	0	1	0	1	0	0	3	3	2	2	5	2	5	2	5	2	2	0			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:124053163C>T	uc003ehg.2	+	9	1589	c.1462C>T	c.(1462-1464)CCT>TCT	p.P488S	KALRN_uc010hrv.1_Missense_Mutation_p.P488S|KALRN_uc003ehf.1_Missense_Mutation_p.P488S|KALRN_uc011bjy.1_Missense_Mutation_p.P488S	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	488					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GCCCCTGAGCCCTGGGAACTC	0.567													35	100					0	0	0	0	T	124053163	T	T	124053163	3	4	123	1	0	0	0	0	1	0	0	0	8014	623	22	4	1496	4	KALRN	3	124053163	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	12415215	124053163	73969267	27	22019											
CLDN1	9076	broad.mit.edu	37	chr3	190026161	190026161	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggacaggaacagcaaagtaGggcacctcccagaaggcaga	15	2	14	10	0	0	2	0	0	0	2	1	4	1	4	2	4	2	4	2	4	4	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:190026161G>A	uc003fsh.2	-	4	761	c.541C>T	c.(541-543)CTA>TTA	p.L181L		NM_021101	NP_066924	O95832	CLD1_HUMAN	claudin 1	181	Helical; (Potential).				calcium-independent cell-cell adhesion|interspecies interaction between organisms	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity			lung(1)	1	all_cancers(143;2.95e-10)|Ovarian(172;0.0512)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.015)		CAGCAAAGTAGGGCACCTCCC	0.512													22	119					0	0	0	0	A	190026161	A	A	190026161	2	1	123	1	0	0	0	0	0	0	0	1	3486	991	35	4		4	CLDN1	3	190026161	Silent	SNP	G	TCGA-CR-6473-01A-11D-1870-08	65972998	190026161	7996269	28	22020											
ATP13A5	344905	broad.mit.edu	37	chr3	193068904	193068904	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggagataacagtcaaaatGatgatggccacagagtattc	16	9	10	6	0	1	4	1	2	0	2	2	5	1	4	1	2	1	1	1	2	4	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:193068904G>A	uc011bsq.1	-	7	693	c.693C>T	c.(691-693)ATC>ATT	p.I231I		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	231	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CAGTCAAAATGATGATGGCCA	0.393													30	58					0	0	0	0	A	193068904	A	A	193068904	2	1	123	1	0	0	0	0	0	0	0	1	1129	1280	45	2		2	ATP13A5	3	193068904	Silent	SNP	G	TCGA-CR-6473-01A-11D-1870-08	3042743	193068904	4953526	29	22021											
SENP5	205564	broad.mit.edu	37	chr3	196657755	196657755	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atgccccgagtgcggaagagGatttacaaggagctatgtga	12	8	14	7	2	0	2	0	1	0	1	0	6	0	5	2	3	4	1	2	3	4	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr3:196657755G>C	uc003fwz.3	+	10	2478	c.2229G>C	c.(2227-2229)AGG>AGC	p.R743S	SENP5_uc011bty.1_Missense_Mutation_p.R697S	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	743					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		TGCGGAAGAGGATTTACAAGG	0.488													22	61					0	0	0	0	C	196657755	C	C	196657755	3	2	123	1	0	0	0	0	1	0	0	0	14114	1165	41	2	2263	2	SENP5	3	196657755	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	3588851	196657755	1364675	30	22022											
CEP135	9662	broad.mit.edu	37	chr4	56841014	56841014	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacatttctgaaaggtatagAagaagaacgagattattata	18	12	8	3	1	1	5	0	1	1	4	1	6	1	5	0	1	2	1	0	1	10	7			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr4:56841014A>G	uc003hbi.2	+	11	1586	c.1352A>G	c.(1351-1353)GAA>GGA	p.E451G	CEP135_uc003hbj.2_Missense_Mutation_p.E157G	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	451	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					AAAGGTATAGAAGAAGAACGA	0.388													30	44					0	0	0	0	G	56841014	G	G	56841014	3	3	123	1	0	0	0	0	1	0	0	0	3262	246	9	5	1390	5	CEP135	4	56841014	Missense_Mutation	SNP	A	TCGA-CR-6473-01A-11D-1870-08		56841014	134313262	31	22023											
GRIA2	2891	broad.mit.edu	37	chr4	158254056	158254056	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaaagaattgaaatctcccGaagggggaatgcaggagact	15	6	13	7	1	1	3	0	1	1	2	2	6	1	4	1	3	1	2	1	3	5	1	rs142538282	byFrequency	TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr4:158254056G>A	uc003ipm.3	+	7	1427	c.968G>A	c.(967-969)CGA>CAA	p.R323Q	GRIA2_uc011cit.1_Missense_Mutation_p.R276Q|GRIA2_uc003ipl.3_Missense_Mutation_p.R323Q|GRIA2_uc003ipk.3_Missense_Mutation_p.R276Q|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	323	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GAAATCTCCCGAAGGGGGAAT	0.478													39	57					0	0	0	0	A	158254056	A	A	158254056	3	1	123	1	0	0	0	0	1	0	0	0	6807	1058	37	1	994	1	GRIA2	4	158254056	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	101413042	158254056	32900220	32	22024											
PTCD2	79810	broad.mit.edu	37	chr5	71654182	71654182	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agggacaggaaatctcacacGttgctattaaacaagaggat	16	8	10	7	1	1	1	1	0	1	1	2	4	1	4	0	3	2	2	0	3	5	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr5:71654182G>A	uc003kcb.2	+	10	1105	c.1095G>A	c.(1093-1095)ACG>ACA	p.T365T	PTCD2_uc011csf.1_Silent_p.T175T|PTCD2_uc003kcc.2_Silent_p.T213T|PTCD2_uc011csg.1_Silent_p.T193T|PTCD2_uc011csh.1_Silent_p.T256T|PTCD2_uc003kcd.2_RNA	NM_024754	NP_079030	Q8WV60	PTCD2_HUMAN	pentatricopeptide repeat domain 2	365											0		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.73e-53)		AATCTCACACGTTGCTATTAA	0.532													31	23					0	0	0	0	A	71654182	A	A	71654182	2	1	123	1	0	0	0	0	0	0	0	1	12790	1132	40	1		1	PTCD2	5	71654182	Silent	SNP	G	TCGA-CR-6473-01A-11D-1870-08		71654182	109261078	33	22025											
MARCH3	115123	broad.mit.edu	37	chr5	126206381	126206381	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atggaggcccagcaaggacgGctggttagaaggtacattga	12	7	15	7	1	0	2	0	1	0	1	0	4	0	4	1	6	2	4	1	6	4	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr5:126206381G>C	uc003kuf.2	-	5	1161	c.706C>G	c.(706-708)CCG>GCG	p.P236A		NM_178450	NP_848545	Q86UD3	MARH3_HUMAN	membrane-associated ring finger (C3HC4) 3	236					endocytosis	cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosome	ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.074)|OV - Ovarian serous cystadenocarcinoma(64;0.0793)		AGCAAGGACGGCTGGTTAGAA	0.463													35	79					0	0	0	0	C	126206381	C	C	126206381	3	2	123	1	0	0	0	0	1	0	0	0	9355	1203	42	4	59	4	MARCH3	5	126206381	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	54552199	126206381	54708879	34	22026											
KLHL3	26249	broad.mit.edu	37	chr5	136974777	136974777	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcatacacatccactgtccGcacccgcagtgagccattaa	11	8	7	15	2	1	1	1	1	0	0	3	1	3	1	4	0	2	2	4	0	2	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr5:136974777G>A	uc010jek.2	-	10	1528	c.1084C>T	c.(1084-1086)CGG>TGG	p.R362W	KLHL3_uc011cyc.1_Missense_Mutation_p.R131W|KLHL3_uc003lbr.3_Missense_Mutation_p.R280W|KLHL3_uc011cyd.1_Intron|KLHL3_uc010jel.1_Missense_Mutation_p.R131W|KLHL3_uc010jem.1_Missense_Mutation_p.R322W	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	362	Kelch 2.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		TCCACTGTCCGCACCCGCAGT	0.592													3	31					0	0	0	0	A	136974777	A	A	136974777	3	1	123	1	0	0	0	0	1	0	0	0	8422	1086	38	1	703	1	KLHL3	5	136974777	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	10768396	136974777	43940483	35	22027											
MFAP3	4238	broad.mit.edu	37	chr5	153429537	153429537	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cactatgaagatgtccattgGcacaattcaaaaggacagca	16	8	8	9	0	1	2	1	1	0	1	2	3	2	3	1	2	1	2	1	2	5	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr5:153429537G>A	uc003lvf.2	+	2	771	c.255G>A	c.(253-255)TGG>TGA	p.W85*	MFAP3_uc010jib.2_Nonsense_Mutation_p.W85*|MFAP3_uc011ddb.1_Intron	NM_001135037	NP_001128509	P55082	MFAP3_HUMAN	microfibrillar-associated protein 3 isoform 2	85	Ig-like C2-type.|Extracellular (Potential).					integral to membrane|plasma membrane					0	Renal(175;0.00488)	Lung NSC(249;0.00145)|all_lung(500;0.00226)|all_neural(177;0.122)|Breast(839;0.14)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;9.69e-06)|GBM - Glioblastoma multiforme(465;0.0201)		ATGTCCATTGGCACAATTCAA	0.418													18	32					0	0	0	0	A	153429537	A	A	153429537	4	1	123	1	0	0	0	0	0	1	0	0	9568	1212	42	4	257	4	MFAP3	5	153429537	Nonsense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	16454760	153429537	27485723	36	22028											
BTN3A3	10384	broad.mit.edu	37	chr6	26448955	26448955	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccctattcattccattgcaGagtggaggaaaatccagtac	12	11	8	10	0	1	1	1	0	0	1	4	3	4	3	3	2	2	2	3	2	4	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr6:26448955G>A	uc003nhz.2	+	8	1118	c.938_splice	c.e8-1	p.K313_splice	BTN3A3_uc003nia.2_Splice_Site_p.K271_splice|BTN3A3_uc011dkn.1_Splice_Site_p.E264_splice	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a							integral to membrane					0						TTCCATTGCAGAGTGGAGGAA	0.448													47	72					0	0	0	0	A	26448955	A	A	26448955	5	1	123	1	0	0	0	0	0	0	1	0	1569	956	33	2	959	2	BTN3A3	6	26448955	Splice_Site	SNP	G	TCGA-CR-6473-01A-11D-1870-08		26448955	144666112	37	22029											
OR12D2	26529	broad.mit.edu	37	chr6	29365090	29365090	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tactgtcacggggacaattgCcatgggccccttctttctga	7	12	10	12	1	3	1	1	1	2	0	3	2	3	2	3	3	2	0	3	3	2	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr6:29365090C>G	uc003nmf.3	+	1	675	c.614C>G	c.(613-615)GCC>GGC	p.A205G		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGGACAATTGCCATGGGCCCC	0.448													59	87					0	0	0	0	G	29365090	G	G	29365090	3	3	123	1	0	0	0	0	1	0	0	0	10985	739	26	4	616	4	OR12D2	6	29365090	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	2916135	29365090	141749977	38	22030											
C6orf154	221424	broad.mit.edu	37	chr6	43476039	43476039	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtattcttgagcctcacccaGggggttgtaatccagattga	9	12	11	9	0	2	3	1	2	1	1	3	3	3	3	3	2	1	3	3	2	2	6			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr6:43476039G>C	uc003ovk.1	-	3	1454	c.553C>G	c.(553-555)CTG>GTG	p.L185V	C6orf154_uc003ovj.1_Intron	NM_001012974	NP_001012992	Q5JTD7	CF154_HUMAN	hypothetical protein LOC221424	185	LRR 5.										0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GCCTCACCCAGGGGGTTGTAA	0.602													11	25					0	0	0	0	C	43476039	C	C	43476039	3	2	123	1	0	0	0	0	1	0	0	0	2349	991	35	4	413	4	C6orf154	6	43476039	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	14110949	43476039	127639028	39	22031											
IGF2R	3482	broad.mit.edu	37	chr6	160469544	160469544	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggctgcaaccgatatgcatCggcttgccagatgaagtatg	10	9	13	9	2	0	2	0	1	0	1	1	3	0	2	2	2	4	5	2	2	4	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr6:160469544C>T	uc003qta.2	+	18	2631	c.2483C>T	c.(2482-2484)TCG>TTG	p.S828L		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	828	6.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CGATATGCATCGGCTTGCCAG	0.483													18	6					0	0	0	0	T	160469544	T	T	160469544	3	4	123	1	0	0	0	0	1	0	0	0	7615	893	31	1	2553	1	IGF2R	6	160469544	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	116993505	160469544	10645523	40	22032											
PDE1C	5137	broad.mit.edu	37	chr7	31890345	31890345	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcaaagatctccagctccGtcagccagttctgaaaggag	12	8	10	11	1	3	2	1	1	2	1	5	3	4	3	3	1	3	3	3	1	3	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr7:31890345G>A	uc003tcm.1	-	8	1230	c.761C>T	c.(760-762)ACG>ATG	p.T254M	PDE1C_uc003tcn.1_Missense_Mutation_p.T254M|PDE1C_uc003tco.1_Missense_Mutation_p.T314M|PDE1C_uc003tcr.2_Missense_Mutation_p.T254M|PDE1C_uc003tcs.2_Missense_Mutation_p.T254M	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	254	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CTCCAGCTCCGTCAGCCAGTT	0.463													35	11					0	0	0	0	A	31890345	A	A	31890345	3	1	123	1	0	0	0	0	1	0	0	0	11689	1145	40	1	1183	1	PDE1C	7	31890345	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08		31890345	127248318	41	22033											
MUC17	140453	broad.mit.edu	37	chr7	100685655	100685655	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggtgaccatttctgaggctgGcacagcttcaacacttcctg	8	11	10	12	0	2	2	1	2	1	0	3	2	3	2	2	3	2	3	2	3	1	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr7:100685655G>A	uc003uxp.1	+	3	11011	c.10958G>A	c.(10957-10959)GGC>GAC	p.G3653D	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3653	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|58.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCTGAGGCTGGCACAGCTTCA	0.493													4	177					0	0	0	0	A	100685655	A	A	100685655	3	1	123	1	0	0	0	0	1	0	0	0	10027	1203	42	4	10968	4	MUC17	7	100685655	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	68795310	100685655	58453008	42	22034											
SSPO	23145	broad.mit.edu	37	chr7	149473162	149473162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccctcctctttgggatggCgtgggccctggctgacgggt	2	11	16	12	2	1	1	0	1	1	0	2	2	2	2	3	5	1	1	3	5	0	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr7:149473162C>T	uc010lpk.2	+	1	32	c.32C>T	c.(31-33)GCG>GTG	p.A11V	ZNF467_uc003wgc.2_5'Flank|ZNF467_uc003wgd.2_5'Flank|SSPO_uc010lpl.1_5'Flank	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	11					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTTGGGATGGCGTGGGCCCTG	0.652													9	8					0	0	0	0	T	149473162	T	T	149473162	3	4	123	1	0	0	0	0	1	0	0	0	15255	768	27	1	34	1	SSPO	7	149473162	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	48787507	149473162	9665501	43	22035											
LRRC67	286187	broad.mit.edu	37	chr8	67925256	67925256	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaggggaagcctctgattCtcaacatgaagctctcttag	11	10	9	11	0	3	2	1	2	3	0	5	3	3	3	2	2	3	1	2	2	5	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr8:67925256C>T	uc003xxc.2	-	4	517	c.372G>A	c.(370-372)GAG>GAA	p.E124E		NM_001013626	NP_001013648	Q7Z4L9	LRC67_HUMAN	leucine rich repeat containing 67	124	LRR 5.										0						GCCTCTGATTCTCAACATGAA	0.383													32	75					0	0	0	0	T	67925256	T	T	67925256	2	4	123	1	0	0	0	0	0	0	0	1	9069	912	32	2		2	LRRC67	8	67925256	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08		67925256	78438766	44	22036											
BAT2L1	84726	broad.mit.edu	37	chr9	134340154	134340154	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacattctcttggcagaagtCatcaatgggcagcatgttcc	10	11	10	10	0	3	1	2	0	1	1	5	2	4	1	1	2	1	4	1	2	2	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr9:134340154C>T	uc004can.3	+	11	1464	c.1409C>T	c.(1408-1410)TCA>TTA	p.S470L	BAT2L1_uc010mzj.1_Missense_Mutation_p.S53L	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	470							protein binding				0						TGGCAGAAGTCATCAATGGGC	0.557													3	16					0	0	0	0	T	134340154	T	T	134340154	3	4	123	1	0	0	0	0	1	0	0	0	1322	838	29	2	1451	2	BAT2L1	9	134340154	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08		134340154	6873277	45	22037											
UPF2	26019	broad.mit.edu	37	chr10	11997456	11997456	+	Frame_Shift_Del	DEL	T	-	-																															cggtaattgtaaagttctccTaagaacttggcactgctgat																										TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr10:11997456delT	uc001ila.2	-	13	3099	c.2625delA	c.(2623-2625)TTAfs	p.L875fs	UPF2_uc001ilb.2_Frame_Shift_Del_p.L875fs|UPF2_uc001ilc.2_Frame_Shift_Del_p.L875fs|UPF2_uc009xiz.1_Frame_Shift_Del_p.L875fs	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	875	Sufficient for interaction with UPF3A and UPF3B.|MIF4G 3.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				AAAGTTCTCCTAAGAACTTGG	0.368													---	---	---								-	11997456	-	-	11997456	7	5	123	1	0	1	0	1	0	0	0	0	17072	1519	53	0	1229	0	UPF2	10	11997456	Frame_Shift_Del	DEL	T	TCGA-CR-6473-01A-11D-1870-08		11997456	123537291	46	22038											
PCDH15	65217	broad.mit.edu	37	chr10	56138640	56138640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attatcctttaaagaaagttCtatggtggggtctggtcctc	9	15	10	7	0	2	1	0	0	2	1	5	1	4	1	2	4	0	1	2	4	5	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr10:56138640C>T	uc001jju.1	-	4	615	c.220G>A	c.(220-222)GAA>AAA	p.E74K	PCDH15_uc010qhq.1_Missense_Mutation_p.E79K|PCDH15_uc010qhr.1_Missense_Mutation_p.E74K|PCDH15_uc010qhs.1_Missense_Mutation_p.E79K|PCDH15_uc010qht.1_Missense_Mutation_p.E74K|PCDH15_uc010qhu.1_Missense_Mutation_p.E74K|PCDH15_uc001jjv.1_Missense_Mutation_p.E52K|PCDH15_uc010qhv.1_Missense_Mutation_p.E74K|PCDH15_uc010qhw.1_Missense_Mutation_p.E74K|PCDH15_uc010qhx.1_Missense_Mutation_p.E74K|PCDH15_uc010qhy.1_Missense_Mutation_p.E79K|PCDH15_uc010qhz.1_Missense_Mutation_p.E74K|PCDH15_uc010qia.1_Missense_Mutation_p.E52K|PCDH15_uc010qib.1_Missense_Mutation_p.E52K|PCDH15_uc001jjw.2_Missense_Mutation_p.E74K	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	74	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AAAGAAAGTTCTATGGTGGGG	0.428										HNSCC(58;0.16)			53	108					0	0	0	0	T	56138640	T	T	56138640	3	4	123	1	0	0	0	0	1	0	0	0	11565	922	32	2	7411	2	PCDH15	10	56138640	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	44141184	56138640	79396107	47	22039											
TTC18	118491	broad.mit.edu	37	chr10	75035242	75035242	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttgttgaaggtattcctCtgccttggcaaagttcttct	6	17	9	9	0	3	1	0	1	3	0	4	1	4	1	2	2	2	5	2	2	3	7			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr10:75035242C>G	uc009xrc.2	-	23	2966	c.2845G>C	c.(2845-2847)GAG>CAG	p.E949Q	TTC18_uc001jty.2_Missense_Mutation_p.E949Q|TTC18_uc001jtv.3_Missense_Mutation_p.E53Q|TTC18_uc001jtw.3_Missense_Mutation_p.E53Q|TTC18_uc001jtx.2_Missense_Mutation_p.E330Q	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	949	TPR 4.						binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					AGGTATTCCTCTGCCTTGGCA	0.473													76	76					0	0	0	0	G	75035242	G	G	75035242	3	3	123	1	0	0	0	0	1	0	0	0	16753	922	32	2	544	2	TTC18	10	75035242	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	18896602	75035242	60499505	48	22040											
CWF19L1	55280	broad.mit.edu	37	chr10	101997927	101997927	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccaccactgactggtagtgtCcaataggcaggatgaggaca	12	7	12	10	0	0	2	0	2	0	0	1	4	1	4	3	4	0	2	3	4	3	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr10:101997927C>T	uc001kqq.1	-	11	1193	c.1106G>A	c.(1105-1107)GGA>GAA	p.G369E	CWF19L1_uc001kqs.1_Missense_Mutation_p.G121E|CWF19L1_uc001kqr.1_Missense_Mutation_p.G369E|CWF19L1_uc001kqt.1_Missense_Mutation_p.G73E|CWF19L1_uc010qpn.1_Missense_Mutation_p.G232E|SNORA12_uc001kqu.1_5'Flank	NM_018294	NP_060764	Q69YN2	C19L1_HUMAN	CWF19-like 1, cell cycle control	369							catalytic activity				0		Colorectal(252;0.117)		Epithelial(162;3.78e-10)|all cancers(201;3.1e-08)		CTGGTAGTGTCCAATAGGCAG	0.498													64	120					0	0	0	0	T	101997927	T	T	101997927	3	4	123	1	0	0	0	0	1	0	0	0	4088	855	30	2	526	2	CWF19L1	10	101997927	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	26962685	101997927	33536820	49	22041											
CNNM2	54805	broad.mit.edu	37	chr10	104678631	104678631	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcggcgccacagcccggggGagcgcgggctggggggcccc	3	1	22	15	5	0	0	0	0	0	0	0	1	0	1	4	8	2	1	4	8	0	0			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr10:104678631G>C	uc001kwm.2	+	1	518	c.394G>C	c.(394-396)GAG>CAG	p.E132Q	CNNM2_uc001kwn.2_Missense_Mutation_p.E132Q|CNNM2_uc001kwl.2_Missense_Mutation_p.E132Q	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	132					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CAgcccgggggagcgcgggct	0.517													20	19					0	0	0	0	C	104678631	C	C	104678631	3	2	123	1	0	0	0	0	1	0	0	0	3628	1175	41	2	396	2	CNNM2	10	104678631	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	2680704	104678631	30856116	50	22042											
DMBT1	1755	broad.mit.edu	37	chr10	124380632	124380632	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacaggtgtcgaggccgaGtggaggtcctgtatcgaggc	7	8	18	8	3	0	1	0	1	0	0	3	5	1	2	2	5	0	1	2	5	1	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr10:124380632G>T	uc001lgk.1	+	41	5063	c.4957G>T	c.(4957-4959)GTG>TTG	p.V1653L	DMBT1_uc001lgl.1_Missense_Mutation_p.V1643L|DMBT1_uc001lgm.1_Missense_Mutation_p.V1025L|DMBT1_uc009xzz.1_Missense_Mutation_p.V1653L|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Missense_Mutation_p.V356L|DMBT1_uc009yac.1_5'UTR	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1653	SRCR 13.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TCGAGGCCGAGTGGAGGTCCT	0.562													130	207					4.56115e-48	5.20731e-48	1	0	T	124380632	T	T	124380632	3	4	123	1	0	0	0	0	1	0	0	0	4599	1029	36	4	5119	4	DMBT1	10	124380632	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	19702001	124380632	11154115	51	22043											
OR52B2	255725	broad.mit.edu	37	chr11	6190885	6190885	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcaaacgaaacactgctcgGaggatcagtgagtaagacac	15	5	12	9	2	1	2	1	1	0	1	2	5	1	4	0	3	3	3	0	3	3	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr11:6190885G>A	uc010qzy.1	-	1	672	c.672C>T	c.(670-672)CTC>CTT	p.L224L		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACACTGCTCGGAGGATCAGTG	0.498													15	21					0	0	0	0	A	6190885	A	A	6190885	2	1	123	1	0	0	0	0	0	0	0	1	11165	1161	41	2		2	OR52B2	11	6190885	Silent	SNP	G	TCGA-CR-6473-01A-11D-1870-08		6190885	128815631	52	22044											
PSMA1	5682	broad.mit.edu	37	chr11	14632514	14632514	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcaaagatattctcacctTcaccttgctgagctgcataa	13	11	6	11	0	2	2	2	1	1	1	3	2	2	2	2	0	4	4	2	0	4	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr11:14632514T>A	uc001mll.2	-	2	364	c.19A>T	c.(19-21)AAG>TAG	p.K7*		NM_148976	NP_683877	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 1	Error:Variant_position_missing_in_P25786_after_alignment					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						ATTCTCACCTTCACCTTGCTG	0.418													7	17					0	0	0	0	A	14632514	A	A	14632514	4	1	123	1	0	0	0	0	0	1	0	0	12728	1792	62	5	887	5	PSMA1	11	14632514	Nonsense_Mutation	SNP	T	TCGA-CR-6473-01A-11D-1870-08	8441629	14632514	120374002	53	22045											
KCNC1	3746	broad.mit.edu	37	chr11	17793798	17793798	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgagcacacgcactttaagaAcatccccatcggcttctggt	10	10	8	13	2	1	2	0	1	1	1	3	2	2	2	2	2	2	3	2	2	2	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr11:17793798A>G	uc001mnk.3	+	2	1212	c.1157A>G	c.(1156-1158)AAC>AGC	p.N386S	KCNC1_uc009yhc.1_Missense_Mutation_p.N386S	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	386						voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						CACTTTAAGAACATCCCCATC	0.617													29	50					0	0	0	0	G	17793798	G	G	17793798	3	3	123	1	0	0	0	0	1	0	0	0	8053	43	2	5	1163	5	KCNC1	11	17793798	Missense_Mutation	SNP	A	TCGA-CR-6473-01A-11D-1870-08	3161284	17793798	117212718	54	22046											
GTF2H1	2965	broad.mit.edu	37	chr11	18359808	18359808	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taagcaggatgttggcatttCtgctgcatttctggtatgtg	7	16	12	6	0	2	0	0	0	2	0	2	1	2	1	0	3	3	6	0	3	2	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr11:18359808C>G	uc001moi.2	+	5	1194	c.500C>G	c.(499-501)TCT>TGT	p.S167C	GTF2H1_uc001moh.2_Missense_Mutation_p.S167C|GTF2H1_uc009yhm.2_Missense_Mutation_p.S51C	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	167					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding				0						GTTGGCATTTCTGCTGCATTT	0.368								NER					52	64					0	0	0	0	G	18359808	G	G	18359808	3	3	123	1	0	0	0	0	1	0	0	0	6899	913	32	2	510	2	GTF2H1	11	18359808	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	566010	18359808	116646708	55	22047											
NPAS4	266743	broad.mit.edu	37	chr11	66191925	66191925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcacagccaccttcccagagCctctgggcagccctgcccat	7	6	9	19	0	1	1	0	0	1	1	2	1	2	1	6	1	4	2	6	1	0	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr11:66191925C>T	uc001ohx.1	+	7	1740	c.1564C>T	c.(1564-1566)CCT>TCT	p.P522S	NPAS4_uc010rpc.1_Missense_Mutation_p.P312S	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	522					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CTTCCCAGAGCCTCTGGGCAG	0.597													6	216					0	0	0	0	T	66191925	T	T	66191925	3	4	123	1	0	0	0	0	1	0	0	0	10619	739	26	4	1590	4	NPAS4	11	66191925	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	47832117	66191925	68814591	56	22048											
PGR	5241	broad.mit.edu	37	chr11	100999748	100999748	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccgacctcgggggagggCgggccgcccgccacgtgggg	4	3	20	14	6	0	0	0	0	0	0	2	3	1	1	5	6	0	0	5	6	0	0			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr11:100999748C>T	uc001pgh.2	-	1	797	c.54G>A	c.(52-54)CCG>CCA	p.P18P	PGR_uc001pgi.2_Silent_p.P18P|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	18	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CGGGGGAGGGCGGGCCGCCCG	0.682													6	0					0	0	0	0	T	100999748	T	T	100999748	2	4	123	1	0	0	0	0	0	0	0	1	11860	755	27	1		1	PGR	11	100999748	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	34807823	100999748	34006768	57	22049											
KCNA6	3742	broad.mit.edu	37	chr12	4919430	4919430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaccctggccggcgagtcCgcttcttcgaccccctgagg	5	7	13	16	4	1	2	0	1	1	1	3	5	2	2	5	3	0	1	5	3	0	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr12:4919430C>T	uc001qng.2	+	1	1089	c.223C>T	c.(223-225)CGC>TGC	p.R75C		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	75						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CCGGCGAGTCCGCTTCTTCGA	0.632										HNSCC(72;0.22)			30	29					0	0	0	0	T	4919430	T	T	4919430	3	4	123	1	0	0	0	0	1	0	0	0	8046	652	23	1	225	1	KCNA6	12	4919430	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08		4919430	128932465	58	22050											
BICD1	636	broad.mit.edu	37	chr12	32458713	32458713	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccagctggaagatgccaTccgattgaaagagattgctg	12	8	12	9	1	0	3	0	1	0	2	1	6	1	4	3	1	4	2	3	1	2	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr12:32458713T>A	uc001rku.2	+	4	743	c.662T>A	c.(661-663)ATC>AAC	p.I221N	BICD1_uc001rkv.2_Missense_Mutation_p.I221N|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	221	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			GAAGATGCCATCCGATTGAAA	0.463													16	27					0	0	0	0	A	32458713	A	A	32458713	3	1	123	1	0	0	0	0	1	0	0	0	1431	1435	50	5	676	5	BICD1	12	32458713	Missense_Mutation	SNP	T	TCGA-CR-6473-01A-11D-1870-08	27539283	32458713	101393182	59	22051											
PPHLN1	51535	broad.mit.edu	37	chr12	42745801	42745801	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgattaccgagactatgacGagggccgcagtttttctcat	9	13	10	9	3	1	3	1	2	1	1	2	5	1	3	2	1	1	2	2	1	2	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr12:42745801G>A	uc001rng.1	+	3	292	c.187G>A	c.(187-189)GAG>AAG	p.E63K	PPHLN1_uc001rmy.2_Missense_Mutation_p.E81K|PPHLN1_uc001rna.2_Intron|PPHLN1_uc001rne.2_Missense_Mutation_p.E70K|PPHLN1_uc001rnb.2_Missense_Mutation_p.E70K|PPHLN1_uc001rnd.2_Intron|PPHLN1_uc001rnc.2_Missense_Mutation_p.E63K|PPHLN1_uc001rnf.2_Missense_Mutation_p.E63K|PPHLN1_uc010skq.1_Intron|PPHLN1_uc010skr.1_Intron|PPHLN1_uc010sks.1_Intron|PPHLN1_uc010skt.1_Intron|PPHLN1_uc001rni.1_Intron|PPHLN1_uc001rnh.1_Intron|PPHLN1_uc010sku.1_Intron	NM_016488	NP_057572	Q8NEY8	PPHLN_HUMAN	periphilin 1 isoform 1	63					keratinization	cytoplasm|nucleus				ovary(1)|breast(1)	2	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		AGACTATGACGAGGGCCGCAG	0.393													23	18					0	0	0	0	A	42745801	A	A	42745801	3	1	123	1	0	0	0	0	1	0	0	0	12370	1059	37	1	218	1	PPHLN1	12	42745801	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	10287088	42745801	91106094	60	22052											
MLL2	8085	broad.mit.edu	37	chr12	49436602	49436602	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccagatgctgttctcgttCagagcccagaacatccttga	10	10	8	13	1	2	4	1	1	1	3	4	4	3	4	3	0	3	3	3	0	1	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr12:49436602C>A	uc001rta.3	-	26	5704	c.5704G>T	c.(5704-5706)GAA>TAA	p.E1902*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1902					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGTTCTCGTTCAGAGCCCAGA	0.547			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			36	37					1.36615e-20	1.52164e-20	1	0	A	49436602	A	A	49436602	4	1	123	1	0	0	0	0	0	1	0	0	9674	835	29	2	11025	2	MLL2	12	49436602	Nonsense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	6690801	49436602	84415293	61	22053											
KRT73	319101	broad.mit.edu	37	chr12	53005099	53005099	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccatgccggccggctgctagCtgcagctcctggaactagag	7	7	13	14	2	0	1	0	0	0	1	1	2	1	2	4	3	6	5	4	3	3	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr12:53005099C>G	uc001sas.2	-	6	1034	c.999G>C	c.(997-999)CAG>CAC	p.Q333H		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	333	Rod.|Coil 2.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		CGGCTGCTAGCTGCAGCTCCT	0.547													25	27					0	0	0	0	G	53005099	G	G	53005099	3	3	123	1	0	0	0	0	1	0	0	0	8525	796	28	4	639	4	KRT73	12	53005099	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	3568497	53005099	80846796	62	22054											
ACADS	35	broad.mit.edu	37	chr12	121175211	121175211	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaaggagcagaagcaggCgtgggtcacgcctttcacca	10	6	12	13	2	2	1	2	0	0	1	3	2	3	2	3	3	2	2	3	3	2	1	rs17848085		TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr12:121175211C>T	uc001tza.3	+	4	531	c.413C>T	c.(412-414)GCG>GTG	p.A138V	ACADS_uc010szl.1_Missense_Mutation_p.A138V|ACADS_uc001tzb.3_Missense_Mutation_p.A65V	NM_000017	NP_000008	P16219	ACADS_HUMAN	short-chain acyl-CoA dehydrogenase precursor	138						mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(2)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)	CAGAAGCAGGCGTGGGTCACG	0.622													18	31					0	0	0	0	T	121175211	T	T	121175211	3	4	123	1	0	0	0	0	1	0	0	0	114	768	27	1	427	1	ACADS	12	121175211	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	68170112	121175211	12676684	63	22055											
PSPC1	55269	broad.mit.edu	37	chr13	20277482	20277482	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catctgagatggtggtccttGaggaaatctgtcattgtgct	8	14	12	7	0	3	2	1	2	2	1	4	4	4	3	1	3	1	1	1	3	1	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr13:20277482G>C	uc001uml.2	-	9	1591	c.1405C>G	c.(1405-1407)CAA>GAA	p.Q469E	PSPC1_uc001umj.1_Intron|PSPC1_uc001umk.1_Intron	NM_001042414	NP_001035879	Q8WXF1	PSPC1_HUMAN	paraspeckle protein 1	469	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)	1		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		GGTGGTCCTTGAGGAAATCTG	0.438													11	21					0	0	0	0	C	20277482	C	C	20277482	3	2	123	1	0	0	0	0	1	0	0	0	12778	1299	45	2	170	2	PSPC1	13	20277482	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08		20277482	94892396	64	22056											
BRCA2	675	broad.mit.edu	37	chr13	32972674	32972674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaagtaattcaatagctgacGaagaacttgcattgataaat	18	11	7	5	1	1	3	1	2	0	1	1	4	1	3	0	0	3	3	0	0	8	6	rs28897761		TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr13:32972674G>A	uc001uub.1	+	27	10251	c.10024G>A	c.(10024-10026)GAA>AAA	p.E3342K		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3342					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AATAGCTGACGAAGAACTTGC	0.358			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			10	27					0	0	0	0	A	32972674	A	A	32972674	3	1	123	1	0	0	0	0	1	0	0	0	1504	1059	37	1	10126	1	BRCA2	13	32972674	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	12695192	32972674	82197204	65	22057											
ZIC2	7546	broad.mit.edu	37	chr13	100635350	100635350	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgggctgtggcaaagtcttCgcgcgctccgagaacctcaa	8	7	12	14	5	2	1	1	0	1	1	4	2	3	1	3	2	1	3	3	2	3	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr13:100635350C>T	uc001von.2	+	1	1032	c.1032C>T	c.(1030-1032)TTC>TTT	p.F344F		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	344	C2H2-type 3.				brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GCAAAGTCTTCGCGCGCTCCG	0.617													27	41					0	0	0	0	T	100635350	T	T	100635350	2	4	123	1	0	0	0	0	0	0	0	1	17746	883	31	1		1	ZIC2	13	100635350	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	67662676	100635350	14534528	66	22058											
EDDM3A	10876	broad.mit.edu	37	chr14	21216174	21216174	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaggattatagaacctatCagcaactagaaagtctatgc	15	10	8	8	0	2	3	1	1	1	2	2	4	2	4	1	1	4	1	1	1	8	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr14:21216174C>T	uc001vyb.2	+	2	502	c.435C>T	c.(433-435)ATC>ATT	p.I145I	EDDM3A_uc001vyc.2_Silent_p.I145I	NM_006683	NP_006674	Q14507	EP3A_HUMAN	human epididymis-specific 3 alpha precursor	145					sperm displacement	extracellular space					0						TAGAACCTATCAGCAACTAGA	0.453													22	24					0	0	0	0	T	21216174	T	T	21216174	2	4	123	1	0	0	0	0	0	0	0	1	4931	816	29	2		2	EDDM3A	14	21216174	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08		21216174	86133366	67	22059											
FSCB	84075	broad.mit.edu	37	chr14	44975037	44975037	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttttgtgctgagggagacCgaatttcaccaagaagctct	10	11	10	10	1	2	3	1	1	1	2	2	5	2	3	3	1	2	2	3	1	3	3	rs138964489		TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr14:44975037C>T	uc001wvn.2	-	1	1463	c.1154G>A	c.(1153-1155)CGG>CAG	p.R385Q		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	385	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TGAGGGAGACCGAATTTCACC	0.527													44	77					0	0	0	0	T	44975037	T	T	44975037	3	4	123	1	0	0	0	0	1	0	0	0	6100	652	23	1	1327	1	FSCB	14	44975037	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	23758863	44975037	62374503	68	22060											
MAP3K9	4293	broad.mit.edu	37	chr14	71267584	71267584	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctccttcagacatacccctCttagggcaatgatgttgggg	8	11	11	11	0	2	2	1	1	1	1	3	2	3	2	3	3	1	3	3	3	3	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr14:71267584C>T	uc001xmm.2	-	2	620	c.620G>A	c.(619-621)AGA>AAA	p.R207K	MAP3K9_uc001xml.2_Missense_Mutation_p.R207K	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	207	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		ACATACCCCTCTTAGGGCAAT	0.532													41	49					0	0	0	0	T	71267584	T	T	71267584	3	4	123	1	0	0	0	0	1	0	0	0	9310	913	32	2	2784	2	MAP3K9	14	71267584	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	26292547	71267584	36081956	69	22061											
DNAL1	83544	broad.mit.edu	37	chr14	74125657	74125657	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtccatgcttgctaattgCgagtaagttctcttttcatc	7	18	7	9	1	2	0	1	0	1	0	5	1	3	0	1	0	3	4	1	0	2	8			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr14:74125657C>T	uc001xoq.3	+	3	315	c.150C>T	c.(148-150)TGC>TGT	p.C50C	DNAL1_uc010aru.2_Silent_p.C11C|DNAL1_uc010arv.2_Intron	NM_031427	NP_113615	Q4LDG9	DNAL1_HUMAN	axonemal dynein light chain 1	50	LRR 1.										0				BRCA - Breast invasive adenocarcinoma(234;0.00384)|KIRC - Kidney renal clear cell carcinoma(182;0.095)		TTGCTAATTGCGAGTAAGTTC	0.403													122	183					0	0	0	0	T	74125657	T	T	74125657	2	4	123	1	0	0	0	0	0	0	0	1	4679	776	27	1		1	DNAL1	14	74125657	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	2858073	74125657	33223883	70	22062											
DYNC1H1	1778	broad.mit.edu	37	chr14	102509067	102509067	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacgttcagcagcattccCgtctcacggatatgcaaggt	10	9	11	11	3	2	0	2	0	1	0	4	2	3	2	1	3	3	4	1	3	2	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr14:102509067C>T	uc001yks.2	+	69	12659	c.12495C>T	c.(12493-12495)CCC>CCT	p.P4165P		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4165	AAA 6 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GCAGCATTCCCGTCTCACGGA	0.557													13	14					0	0	0	0	T	102509067	T	T	102509067	2	4	123	1	0	0	0	0	0	0	0	1	4863	639	23	1		1	DYNC1H1	14	102509067	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	28383410	102509067	4840473	71	22063											
EIF2AK4	440275	broad.mit.edu	37	chr15	40259747	40259747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagcttcgcaggtacacagCtcagctcctgtcaggccttg	7	10	10	14	1	3	0	3	0	0	0	5	0	4	0	2	2	4	5	2	2	1	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr15:40259747C>T	uc001zkm.1	+	9	1270	c.1220C>T	c.(1219-1221)GCT>GTT	p.A407V	EIF2AK4_uc001zkl.2_Missense_Mutation_p.A407V|EIF2AK4_uc010bbj.1_Missense_Mutation_p.A136V	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	407	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AGGTACACAGCTCAGCTCCTG	0.532													26	36					0	0	0	0	T	40259747	T	T	40259747	3	4	123	1	0	0	0	0	1	0	0	0	5021	797	28	4	1254	4	EIF2AK4	15	40259747	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08		40259747	62271645	72	22064											
C15orf59	388135	broad.mit.edu	37	chr15	74043429	74043429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcaccaccactgctggggtCgtcactgggctgcccgaggt	5	8	13	15	2	2	0	2	0	0	0	3	1	2	0	3	4	2	2	3	4	0	0			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr15:74043429C>T	uc002avy.2	-	1	388	c.43G>A	c.(43-45)GAC>AAC	p.D15N		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	15										pancreas(1)	1						CTGCTGGGGTCGTCACTGGGC	0.652													34	49					0	0	0	0	T	74043429	T	T	74043429	3	4	123	1	0	0	0	0	1	0	0	0	1813	884	31	1	846	1	C15orf59	15	74043429	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	33783682	74043429	28487963	73	22065											
SOX8	30812	broad.mit.edu	37	chr16	1035131	1035131	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccgactacggttcctgcagCggccagtccagcgccacccc	6	5	10	20	4	0	0	0	0	0	0	2	1	2	0	7	2	4	2	7	2	1	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr16:1035131C>T	uc002ckn.2	+	3	1201	c.1086C>T	c.(1084-1086)AGC>AGT	p.S362S		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	362					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				GTTCCTGCAGCGGCCAGTCCA	0.622													4	1					0	0	0	0	T	1035131	T	T	1035131	2	4	123	1	0	0	0	0	0	0	0	1	15021	767	27	1		1	SOX8	16	1035131	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08		1035131	89319622	74	22066											
FLYWCH1	84256	broad.mit.edu	37	chr16	2980808	2980810	+	In_Frame_Del	DEL	GGA	-	-																															gtgctgagcaagccggccctGgaggaggaggaggcaccccg																										TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr16:2980808_2980810delGGA	uc002csd.2	+	4	1086_1088	c.723_725delGGA	c.(721-726)CTGGAG>CTG	p.E245del	FLYWCH1_uc002csb.2_In_Frame_Del_p.E244del|FLYWCH1_uc002csc.2_In_Frame_Del_p.E244del|FLYWCH1_uc010bsv.2_5'Flank	NM_032296	NP_115672	Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1 isoform a	245	Poly-Glu.					nucleus	DNA binding|metal ion binding				0						AGCCGGCCCTGGAGGAGGAGGAG	0.704													---	---	---								-	2980810	-	-	2980808	7	5	123	1	0	1	0	1	0	0	0	0	5979	1335	47	0	726	0	FLYWCH1	16	2980808	In_Frame_Del	DEL	GGA	TCGA-CR-6473-01A-11D-1870-08	1945677	2980808	87373945	75	22067											
NLRC5	84166	broad.mit.edu	37	chr16	57063689	57063689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttggtctcctcgcagttttCgggacaaccagctcagtgac	7	11	10	13	2	2	1	1	1	1	0	5	2	2	2	2	2	2	3	2	2	1	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr16:57063689C>T	uc002ekk.1	+	9	2473	c.2248C>T	c.(2248-2250)CGG>TGG	p.R750W	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Intron|NLRC5_uc002ekl.2_Missense_Mutation_p.R555W|NLRC5_uc002ekm.2_Missense_Mutation_p.R555W|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	750	LRR 3.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				TCGCAGTTTTCGGGACAACCA	0.582													8	8					0	0	0	0	T	57063689	T	T	57063689	3	4	123	1	0	0	0	0	1	0	0	0	10524	875	31	1	2274	1	NLRC5	16	57063689	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	54082881	57063689	33291064	76	22068											
GFOD2	81577	broad.mit.edu	37	chr16	67709163	67709163	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccggatcggctcgacctcttGatggcatccaccacgctctg	6	9	10	16	4	2	1	0	1	2	0	5	3	3	2	4	3	0	3	4	3	0	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr16:67709163G>C	uc002eub.2	-	3	1348	c.1053C>G	c.(1051-1053)ATC>ATG	p.I351M	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Missense_Mutation_p.I246M	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	351						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		TCGACCTCTTGATGGCATCCA	0.657													35	15					0	0	0	0	C	67709163	C	C	67709163	3	2	123	1	0	0	0	0	1	0	0	0	6381	1280	45	2	108	2	GFOD2	16	67709163	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	10645474	67709163	22645590	77	22069											
MBTPS1	8720	broad.mit.edu	37	chr16	84132744	84132744	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttcaagtgttagcagccccGctttctgtttttcttttatc	5	19	6	11	1	3	0	1	0	2	0	4	0	3	0	2	0	2	4	2	0	3	7			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr16:84132744G>A	uc002fhi.2	-	3	837	c.335C>T	c.(334-336)GCG>GTG	p.A112V		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	112					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						TAGCAGCCCCGCTTTCTGTTT	0.423													9	53					0	0	0	0	A	84132744	A	A	84132744	3	1	123	1	0	0	0	0	1	0	0	0	9414	1087	38	1	2907	1	MBTPS1	16	84132744	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	16423581	84132744	6222009	78	22070											
MYH2	4620	broad.mit.edu	37	chr17	10424679	10424679	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggactcagcaatgtcagccCgttcctcggcctcctccagc	6	8	10	17	2	2	0	2	0	0	0	6	1	5	1	5	2	3	2	5	2	1	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr17:10424679C>T	uc010coi.2	-	40	5872	c.5744G>A	c.(5743-5745)CGG>CAG	p.R1915Q	uc002gml.1_Intron|MYH1_uc002gmo.2_5'Flank|MYH2_uc002gmp.3_Missense_Mutation_p.R1915Q|MYH2_uc010coj.2_Missense_Mutation_p.R682Q	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1915	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AATGTCAGCCCGTTCCTCGGC	0.488													56	115					0	0	0	0	T	10424679	T	T	10424679	3	4	123	1	0	0	0	0	1	0	0	0	10088	652	23	1	85	1	MYH2	17	10424679	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08		10424679	70770531	79	22071											
PIPOX	51268	broad.mit.edu	37	chr17	27382170	27382170	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagacgtccagatcctgagCagctttgtcagagatcactt	10	10	11	10	1	2	4	2	1	0	3	4	6	4	4	2	1	2	2	2	1	0	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr17:27382170C>A	uc002hdr.1	+	6	1223	c.897C>A	c.(895-897)AGC>AGA	p.S299R		NM_016518	NP_057602	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	299					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity				0	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	AGATCCTGAGCAGCTTTGTCA	0.602													17	138					2.37509e-13	2.62409e-13	1	0	A	27382170	A	A	27382170	3	1	123	1	0	0	0	0	1	0	0	0	11998	709	25	4	919	4	PIPOX	17	27382170	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	16957491	27382170	53813040	80	22072											
ABCA10	10349	broad.mit.edu	37	chr17	67153022	67153022	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttccatacttcatttccaGacaccttatgacaaaaagga	15	12	4	10	0	1	2	1	1	0	1	3	3	3	3	3	1	1	0	3	1	4	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr17:67153022G>C	uc010dfa.1	-	29	4285	c.3406C>G	c.(3406-3408)CTG>GTG	p.L1136V	ABCA10_uc010wqs.1_Missense_Mutation_p.L128V|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1136					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TTCATTTCCAGACACCTTATG	0.289													16	12					0	0	0	0	C	67153022	C	C	67153022	3	2	123	1	0	0	0	0	1	0	0	0	29	933	33	2	1273	2	ABCA10	17	67153022	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	39770852	67153022	14042188	81	22073											
ABCA10	10349	broad.mit.edu	37	chr17	67171572	67171572	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatcgctgatgctgctcatgCcgataaaaggagaaacgcag	14	7	11	9	3	1	2	1	1	0	1	2	4	1	2	1	1	4	4	1	1	4	1			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr17:67171572C>T	uc010dfa.1	-	24	3731	c.2852G>A	c.(2851-2853)GGC>GAC	p.G951D	ABCA10_uc010wqs.1_5'UTR|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	951					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GCTGCTCATGCCGATAAAAGG	0.343													4	84					0	0	0	0	T	67171572	T	T	67171572	3	4	123	1	0	0	0	0	1	0	0	0	29	739	26	4	1847	4	ABCA10	17	67171572	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	18550	67171572	14023638	82	22074											
RECQL5	9400	broad.mit.edu	37	chr17	73661241	73661241	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggcatgcacacaaagaCgtccttgttacctgaaaaaa	14	9	9	9	1	0	2	0	1	0	1	1	2	1	2	2	1	2	3	2	1	5	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr17:73661241C>T	uc010dgl.2	-	3	298	c.142G>A	c.(142-144)GTC>ATC	p.V48I	RECQL5_uc010dgk.2_Intron|RECQL5_uc002jpb.1_Missense_Mutation_p.V48I|RECQL5_uc002joz.3_Missense_Mutation_p.V48I|RECQL5_uc002jpa.3_Missense_Mutation_p.V48I	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	48	Helicase ATP-binding.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			CACACAAAGACGTCCTTGTTA	0.378								Other_identified_genes_with_known_or_suspected_DNA_repair_function					45	145					0	0	0	0	T	73661241	T	T	73661241	3	4	123	1	0	0	0	0	1	0	0	0	13268	536	19	1	2992	1	RECQL5	17	73661241	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	6489669	73661241	7533969	83	22075											
MC5R	4161	broad.mit.edu	37	chr18	13826656	13826656	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accctctcatatatgccttcCgcagccaagagatgcggaag	11	8	9	13	2	1	1	1	0	1	1	3	3	2	2	4	1	3	1	4	1	4	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr18:13826656C>T	uc010xaf.1	+	1	892	c.892C>T	c.(892-894)CGC>TGC	p.R298C		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	298	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						ATATGCCTTCCGCAGCCAAGA	0.483													60	73					0	0	0	0	T	13826656	T	T	13826656	3	4	123	1	0	0	0	0	1	0	0	0	9420	652	23	1	894	1	MC5R	18	13826656	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08		13826656	64250592	84	22076											
FEM1A	55527	broad.mit.edu	37	chr19	4793183	4793183	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcagcttcctctccttcgcGgaactcttctcctacgtgct	5	13	7	16	3	3	0	0	0	3	0	7	1	4	1	3	1	5	3	3	1	2	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:4793183G>A	uc002mbf.2	+	1	1456	c.1317G>A	c.(1315-1317)GCG>GCA	p.A439A	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	439					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		TCTCCTTCGCGGAACTCTTCT	0.622													49	83					0	0	0	0	A	4793183	A	A	4793183	2	1	123	1	0	0	0	0	0	0	0	1	5841	1103	39	1		1	FEM1A	19	4793183	Silent	SNP	G	TCGA-CR-6473-01A-11D-1870-08		4793183	54335800	85	22077											
ARRDC5	645432	broad.mit.edu	37	chr19	4903031	4903032	+	5'Flank	INS	-	TCACTGGTTCTTTT	TCACTGGTTCTTTT																															gattgggaaacctgtagtccINStcactggttctttttttttt																								rs144459964	by1000genomes	TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:4903031_4903032insTCACTGGTTCTTTT	uc002mbm.2	-							NM_001080523	NP_001073992	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5						signal transduction						0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		ACCTGTAGTCCTCACTGGttct	0.302													---	---	---								TCACTGGTTCTTTT	4903032	TCACTGGTTCTTTT	TCACTGGTTCTTTT	4903031	6	5	123	0	1	1	1	0	0	0	0	0	988	696	24	0		0	ARRDC5	19	4903031	5'Flank	INS	-	TCGA-CR-6473-01A-11D-1870-08	109848	4903031	54225952	86	22078											
MUC16	94025	broad.mit.edu	37	chr19	9083519	9083519	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccgttgtctctgagttttCagaactctgactgaatacaa	11	13	8	9	1	3	4	1	3	2	1	4	4	3	4	1	0	3	2	1	0	4	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:9083519C>T	uc002mkp.2	-	1	8500	c.8296G>A	c.(8296-8298)GAA>AAA	p.E2766K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2766	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTGAGTTTTCAGAACTCTGA	0.502													27	39					0	0	0	0	T	9083519	T	T	9083519	3	4	123	1	0	0	0	0	1	0	0	0	10026	835	29	2	35563	2	MUC16	19	9083519	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	4180488	9083519	50045464	87	22079			1	26		8	8	4072	C		2.752135e-17
MUC16	94025	broad.mit.edu	37	chr19	9084696	9084696	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagctatggaggtgttgatCagatcagaagaagaactgct	14	9	13	5	0	2	5	2	1	0	4	2	7	2	6	0	2	3	3	0	2	5	2	rs151239264	by1000genomes	TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:9084696C>T	uc002mkp.2	-	1	7323	c.7119G>A	c.(7117-7119)CTG>CTA	p.L2373L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2373	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTGTTGATCAGATCAGAAG	0.443													23	27					0	0	0	0	T	9084696	T	T	9084696	2	4	123	1	0	0	0	0	0	0	0	1	10026	813	29	2		2	MUC16	19	9084696	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	1177	9084696	50044287	88	22080			1	26		8	8	4072	C		2.752135e-17
MUC16	94025	broad.mit.edu	37	chr19	9085596	9085596	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accccagaatggcctgaggaCagtgcctcagataaactagt	13	7	10	11	0	1	3	1	1	0	2	1	4	1	4	4	2	2	0	4	2	4	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:9085596C>T	uc002mkp.2	-	1	6423	c.6219G>A	c.(6217-6219)CTG>CTA	p.L2073L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2073	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCCTGAGGACAGTGCCTCAG	0.473													63	101					0	0	0	0	T	9085596	T	T	9085596	2	4	123	1	0	0	0	0	0	0	0	1	10026	465	17	4		4	MUC16	19	9085596	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	900	9085596	50043387	89	22081			1	26		8	8	4072	C		2.752135e-17
MUC16	94025	broad.mit.edu	37	chr19	9085982	9085982	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgcctgtagaaatgacttCttccactggaatggatgaaa	13	12	9	7	0	1	3	0	2	1	1	2	5	2	5	2	2	1	1	2	2	5	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:9085982C>T	uc002mkp.2	-	1	6037	c.5833G>A	c.(5833-5835)GAA>AAA	p.E1945K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1945	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAATGACTTCTTCCACTGGA	0.488													30	39					0	0	0	0	T	9085982	T	T	9085982	3	4	123	1	0	0	0	0	1	0	0	0	10026	922	32	2	38026	2	MUC16	19	9085982	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	386	9085982	50043001	90	22082			1	26		8	8	4072	C		2.752135e-17
MUC16	94025	broad.mit.edu	37	chr19	9086220	9086220	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctctagtgacaccagtattCaatgacctgtcagtggccaa	11	10	9	11	0	3	2	2	2	1	0	3	2	3	2	3	1	0	2	3	1	4	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:9086220C>G	uc002mkp.2	-	1	5799	c.5595G>C	c.(5593-5595)TTG>TTC	p.L1865F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1865	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CACCAGTATTCAATGACCTGT	0.502													20	28					0	0	0	0	G	9086220	G	G	9086220	3	3	123	1	0	0	0	0	1	0	0	0	10026	825	29	2	38264	2	MUC16	19	9086220	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	238	9086220	50042763	91	22083			1	26		8	8	4072	C		2.752135e-17
MUC16	94025	broad.mit.edu	37	chr19	9086743	9086743	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaatgactggctgatgcttCttcctggagcactagtaaca	10	12	9	10	0	1	2	0	2	1	0	2	3	2	3	1	2	3	4	1	2	3	5			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:9086743C>T	uc002mkp.2	-	1	5276	c.5072G>A	c.(5071-5073)AGA>AAA	p.R1691K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1691	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTGATGCTTCTTCCTGGAGC	0.483													53	56					0	0	0	0	T	9086743	T	T	9086743	3	4	123	1	0	0	0	0	1	0	0	0	10026	913	32	2	38787	2	MUC16	19	9086743	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	523	9086743	50042240	92	22084			1	26		8	8	4072	C		2.752135e-17
MUC16	94025	broad.mit.edu	37	chr19	9086890	9086890	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggctatgcccagggtgactCcactactactgctccctgtt	6	11	10	14	0	0	1	0	1	0	0	2	1	2	1	3	2	4	3	3	2	3	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:9086890C>A	uc002mkp.2	-	1	5129	c.4925G>T	c.(4924-4926)GGA>GTA	p.G1642V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1642	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGGGTGACTCCACTACTACT	0.512													59	99					1.00798e-23	1.14127e-23	1	0	A	9086890	A	A	9086890	3	1	123	1	0	0	0	0	1	0	0	0	10026	855	30	2	38934	2	MUC16	19	9086890	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	147	9086890	50042093	93	22085			1	26		8	8	4072	C		2.752135e-17
MUC16	94025	broad.mit.edu	37	chr19	9087590	9087590	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctggagctgactgtgtctCaaatccagatgatttttctg	8	15	9	9	0	2	3	1	2	2	1	5	4	4	4	2	1	1	1	2	1	1	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:9087590C>G	uc002mkp.2	-	1	4429	c.4225G>C	c.(4225-4227)GAG>CAG	p.E1409Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1409	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACTGTGTCTCAAATCCAGAT	0.473													54	78					0	0	0	0	G	9087590	G	G	9087590	3	3	123	1	0	0	0	0	1	0	0	0	10026	835	29	2	39634	2	MUC16	19	9087590	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	700	9087590	50041393	94	22086			1	26		8	8	4072	C		2.752135e-17
TYK2	7297	broad.mit.edu	37	chr19	10473005	10473005	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccccggccctcagcaagcagCcctgcaaggcagccccaagt	9	3	10	19	1	1	0	1	0	0	0	1	0	1	0	6	2	5	4	6	2	3	0			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:10473005C>T	uc002moc.3	-	11	1982	c.1604G>A	c.(1603-1605)GGC>GAC	p.G535D	TYK2_uc010dxe.2_Missense_Mutation_p.G350D|TYK2_uc002mod.2_Missense_Mutation_p.G535D	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	535					intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CAGCAAGCAGCCCTGCAAGGC	0.652													3	40					0	0	0	0	T	10473005	T	T	10473005	3	4	123	1	0	0	0	0	1	0	0	0	16878	739	26	4	2019	4	TYK2	19	10473005	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	1385415	10473005	48655978	95	22087											
CNN1	1264	broad.mit.edu	37	chr19	11657661	11657661	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctagctggagaacatcggCaacttcatcaaggccatcac	12	8	8	13	1	4	1	3	0	1	1	5	2	4	1	1	3	3	2	1	3	4	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:11657661C>A	uc002msc.1	+	4	431	c.267C>A	c.(265-267)GGC>GGA	p.G89G	CNN1_uc010xmb.1_Silent_p.G39G|CNN1_uc010xmc.1_Silent_p.G39G	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	89	CH.				actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						AGAACATCGGCAACTTCATCA	0.572													8	75					5.18039e-06	5.50166e-06	1	0	A	11657661	A	A	11657661	2	1	123	1	0	0	0	0	0	0	0	1	3624	697	25	4		4	CNN1	19	11657661	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	1184656	11657661	47471322	96	22088											
GRAMD1A	57655	broad.mit.edu	37	chr19	35512474	35512474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcgctcattgagaagaactCgtggagcggcattgaagact	11	9	13	8	3	1	4	1	2	0	3	3	6	1	5	0	2	2	2	0	2	3	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:35512474C>T	uc010xse.1	+	14	1681	c.1544C>T	c.(1543-1545)TCG>TTG	p.S515L	GRAMD1A_uc002nxk.2_Missense_Mutation_p.S508L|GRAMD1A_uc002nxl.2_Missense_Mutation_p.S281L|GRAMD1A_uc010xsf.1_Missense_Mutation_p.S520L|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Missense_Mutation_p.S130L	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	515						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GAGAAGAACTCGTGGAGCGGC	0.582													31	46					0	0	0	0	T	35512474	T	T	35512474	3	4	123	1	0	0	0	0	1	0	0	0	6786	893	31	1	1598	1	GRAMD1A	19	35512474	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	23854813	35512474	23616509	97	22089											
LIN37	55957	broad.mit.edu	37	chr19	36245020	36245020	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcagatcccgcatcccatctCcactgcagcctgagatgcag	9	7	9	16	1	1	2	0	1	1	2	4	3	3	2	4	0	3	4	4	0	0	0			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:36245020C>T	uc002obm.2	+	8	661	c.547C>T	c.(547-549)CCA>TCA	p.P183S	uc002obl.2_5'Flank	NM_019104	NP_061977	Q96GY3	LIN37_HUMAN	lin-37 homolog	183	Pro-rich.						protein binding				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CATCCCATCTCCACTGCAGCC	0.627													24	28					0	0	0	0	T	36245020	T	T	36245020	3	4	123	1	0	0	0	0	1	0	0	0	8849	855	30	2	573	2	LIN37	19	36245020	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08	732546	36245020	22883963	98	22090											
HNRNPL	3191	broad.mit.edu	37	chr19	39330892	39330892	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggtgcccatactgggggccGtagcgacttgggccccgacg	5	6	17	13	4	0	0	0	0	0	0	0	2	0	0	4	4	3	1	4	4	2	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:39330892G>A	uc010xul.1	-	8	1088	c.1077C>T	c.(1075-1077)TAC>TAT	p.Y359Y	HNRNPL_uc010ege.1_Silent_p.Y15Y|HNRNPL_uc002ojj.1_Silent_p.Y15Y|HNRNPL_uc002ojo.1_5'Flank|HNRNPL_uc002ojk.2_Silent_p.Y15Y|HNRNPL_uc002ojl.2_Silent_p.Y15Y|HNRNPL_uc010xum.1_Silent_p.Y226Y|HNRNPL_uc002ojp.1_Silent_p.Y15Y|HNRNPL_uc010xun.1_Missense_Mutation_p.T67M	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	359	Pro-rich.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			ACTGGGGGCCGTAGCGACTTG	0.652													5	6					0	0	0	0	A	39330892	A	A	39330892	2	1	123	1	0	0	0	0	0	0	0	1	7309	1140	40	1		1	HNRNPL	19	39330892	Silent	SNP	G	TCGA-CR-6473-01A-11D-1870-08	3085872	39330892	19798091	99	22091											
PSG9	5678	broad.mit.edu	37	chr19	43763286	43763286	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgtaggggatgggcagcttCgctgtgtggataacagagag	10	9	17	5	1	0	1	0	0	0	1	1	4	0	3	0	4	2	4	0	4	2	3	rs4028446		TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:43763286C>T	uc002owd.3	-	4	810	c.711G>A	c.(709-711)CCG>CCA	p.P237P	PSG9_uc002owe.3_Intron|PSG9_uc010xwm.1_Silent_p.S144S|PSG9_uc002owf.3_Intron|PSG9_uc002owg.2_Intron|PSG9_uc002owh.2_Intron	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	237					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TGGGCAGCTTCGCTGTGTGGA	0.493													74	146					0	0	0	0	T	43763286	T	T	43763286	2	4	123	1	0	0	0	0	0	0	0	1	12724	898	31	1		1	PSG9	19	43763286	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	4432394	43763286	15365697	100	22092											
ZNF667	63934	broad.mit.edu	37	chr19	56969527	56969527	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggttctctgtcactcaccagGagcccggcgtcttcttactg	5	12	10	14	2	5	0	2	0	3	0	6	1	5	1	2	3	2	1	2	3	1	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr19:56969527G>T	uc002qnd.2	-	4	412	c.250C>A	c.(250-252)CCT>ACT	p.P84T	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_Missense_Mutation_p.P84T|ZNF667_uc010etm.2_5'UTR	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	84	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CACTCACCAGGAGCCCGGCGT	0.333													6	73					3.59834e-05	3.79209e-05	1	0	T	56969527	T	T	56969527	3	4	123	1	0	0	0	0	1	0	0	0	18141	1174	41	2	1590	2	ZNF667	19	56969527	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	13206241	56969527	2159456	101	22093											
TPX2	22974	broad.mit.edu	37	chr20	30381707	30381707	+	Frame_Shift_Del	DEL	T	-	-																															gtgccacattatggggtgccTtttaagccccaaatcccaga																										TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr20:30381707delT	uc002wwp.1	+	14	2264	c.1566delT	c.(1564-1566)CCTfs	p.P522fs	TPX2_uc010gdv.1_Frame_Shift_Del_p.P558fs	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	522					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			ATGGGGTGCCTTTTAAGCCCC	0.428													---	---	---								-	30381707	-	-	30381707	7	5	123	1	0	1	0	1	0	0	0	0	16499	1596	56	0	1612	0	TPX2	20	30381707	Frame_Shift_Del	DEL	T	TCGA-CR-6473-01A-11D-1870-08		30381707	32643813	102	22094											
DNMT3B	1789	broad.mit.edu	37	chr20	31379433	31379433	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagacaaactggtggcactGgggctgttcagccagcactt	9	8	13	11	0	1	1	1	0	0	1	1	1	1	1	1	4	3	5	1	4	1	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr20:31379433G>A	uc002wyc.2	+	8	1161	c.840G>A	c.(838-840)CTG>CTA	p.L280L	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Silent_p.L280L|DNMT3B_uc002wye.2_Silent_p.L280L|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Silent_p.L238L|DNMT3B_uc010zua.1_Silent_p.L204L|DNMT3B_uc002wyf.2_Silent_p.L292L|DNMT3B_uc002wyg.2_5'UTR	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	280	PWWP.|Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						TGGTGGCACTGGGGCTGTTCA	0.483													18	154					0	0	0	0	A	31379433	A	A	31379433	2	1	123	1	0	0	0	0	0	0	0	1	4699	1335	47	4		4	DNMT3B	20	31379433	Silent	SNP	G	TCGA-CR-6473-01A-11D-1870-08	997726	31379433	31646087	103	22095											
C20orf185	359710	broad.mit.edu	37	chr20	31651460	31651460	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtgctgggtgtggtgaatGagctcctgggggctgtgctg	3	12	20	6	0	0	2	0	2	0	0	1	2	1	2	1	4	3	4	1	4	1	0			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr20:31651460G>A	uc002wym.1	+	6	631	c.631G>A	c.(631-633)GAG>AAG	p.E211K		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	211	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						TGTGGTGAATGAGCTCCTGGG	0.587													33	190					0	0	0	0	A	31651460	A	A	31651460	3	1	123	1	0	0	0	0	1	0	0	0	2107	1291	45	2	653	2	C20orf185	20	31651460	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	272027	31651460	31374060	104	22096											
HIRA	7290	broad.mit.edu	37	chr22	19346902	19346902	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccggctggtgagtaccgtctCccactccttcccttcccggt	3	11	9	18	3	1	1	0	1	1	0	5	1	4	1	6	3	1	2	6	3	1	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr22:19346902C>T	uc002zpf.1	-	18	2411	c.2191G>A	c.(2191-2193)GAG>AAG	p.E731K	HIRA_uc011agx.1_Missense_Mutation_p.E597K|HIRA_uc010grn.1_Intron|HIRA_uc010gro.1_Missense_Mutation_p.E687K|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	731	Interaction with PAX3 (By similarity).|Interaction with histone H2B.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					AGTACCGTCTCCCACTCCTTC	0.602													38	35					0	0	0	0	T	19346902	T	T	19346902	3	4	123	1	0	0	0	0	1	0	0	0	7159	864	30	2	894	2	HIRA	22	19346902	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08		19346902	31957664	105	22097											
TRMT2A	27037	broad.mit.edu	37	chr22	20103246	20103246	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggcagcaggccttgttgtgCttgtgcctctgctcgagcag	4	11	15	11	1	1	0	0	0	1	0	2	1	1	0	2	2	5	6	2	2	0	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr22:20103246C>T	uc002zrk.1	-	4	872	c.657G>A	c.(655-657)AAG>AAA	p.K219K	TRMT2A_uc002zrl.1_Silent_p.K219K|TRMT2A_uc002zrm.1_Silent_p.K41K|TRMT2A_uc002zrn.1_Silent_p.K219K|TRMT2A_uc011ahk.1_Silent_p.K219K|RANBP1_uc011ahl.1_5'Flank|RANBP1_uc002zro.1_5'Flank|RANBP1_uc002zrp.2_5'Flank	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	219					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						CCTTGTTGTGCTTGTGCCTCT	0.602													10	19					0	0	0	0	T	20103246	T	T	20103246	2	4	123	1	0	0	0	0	0	0	0	1	16632	796	28	4		4	TRMT2A	22	20103246	Silent	SNP	C	TCGA-CR-6473-01A-11D-1870-08	756344	20103246	31201320	106	22098											
ASPHD2	57168	broad.mit.edu	37	chr22	26829615	26829615	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttgggacccccgaggactGattgtctgaccttgcttcac	6	11	10	14	1	2	2	1	2	1	0	2	5	2	4	4	2	1	1	4	2	0	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr22:26829615G>C	uc003acg.2	+	2	431	c.34G>C	c.(34-36)GAT>CAT	p.D12H		NM_020437	NP_065170	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	12	Cytoplasmic (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			ovary(1)	1						CCCGAGGACTGATTGTCTGAC	0.652													11	20					0	0	0	0	C	26829615	C	C	26829615	3	2	123	1	0	0	0	0	1	0	0	0	1057	1290	45	2	36	2	ASPHD2	22	26829615	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	6726369	26829615	24474951	107	22099											
ARFGAP3	26286	broad.mit.edu	37	chr22	43206867	43206867	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgtttcagtatctttgctgGtctcttttttccaataggaa	7	19	7	8	0	3	0	1	0	2	0	5	1	4	1	1	2	1	3	1	2	4	7			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr22:43206867G>T	uc003bdd.2	-	12	1368	c.1148C>A	c.(1147-1149)ACC>AAC	p.T383N	ARFGAP3_uc010gzf.2_Missense_Mutation_p.T339N	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	383					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						ATCTTTGCTGGTCTCTTTTTT	0.428													50	67					2.29192e-23	2.57371e-23	1	0	T	43206867	T	T	43206867	3	4	123	1	0	0	0	0	1	0	0	0	851	1261	44	4	422	4	ARFGAP3	22	43206867	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	16377252	43206867	8097699	108	22100											
TBC1D22A	25771	broad.mit.edu	37	chr22	47393590	47393590	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaaatgttagaagaactcGtgagccggattgatggtaag	14	10	13	4	2	0	5	0	3	0	2	1	6	0	6	1	2	2	2	1	2	6	3			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chr22:47393590G>A	uc003bib.2	+	10	1321	c.1186G>A	c.(1186-1188)GTG>ATG	p.V396M	TBC1D22A_uc010haf.2_Missense_Mutation_p.V366M|TBC1D22A_uc003bic.2_Missense_Mutation_p.V337M|TBC1D22A_uc003bie.2_Missense_Mutation_p.V318M|TBC1D22A_uc003bid.2_RNA|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_Missense_Mutation_p.V349M	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	396	Rab-GAP TBC.					intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		AGAAGAACTCGTGAGCCGGAT	0.507													43	52					0	0	0	0	A	47393590	A	A	47393590	3	1	123	1	0	0	0	0	1	0	0	0	15677	1145	40	1	1224	1	TBC1D22A	22	47393590	Missense_Mutation	SNP	G	TCGA-CR-6473-01A-11D-1870-08	4186723	47393590	3910976	109	22101											
TMEM164	84187	broad.mit.edu	37	chrX	109310602	109310602	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcctggcctgccctccatgtCggggagctatcgtcgtcttc	3	12	11	15	3	1	0	0	0	1	0	7	1	3	1	4	3	2	1	4	3	1	2			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chrX:109310602C>T	uc004eom.2	+	3	737	c.418C>T	c.(418-420)CGG>TGG	p.R140W	TMEM164_uc004eol.2_5'UTR|TMEM164_uc010npq.2_Intron	NM_032227	NP_115603	Q5U3C3	TM164_HUMAN	transmembrane protein 164 isoform b	140						integral to membrane				large_intestine(1)|lung(1)|skin(1)	3						CCCTCCATGTCGGGGAGCTAT	0.403													41	63					0	0	0	0	T	109310602	T	T	109310602	3	4	123	1	0	0	0	0	1	0	0	0	16145	875	31	1	424	1	TMEM164	23	109310602	Missense_Mutation	SNP	C	TCGA-CR-6473-01A-11D-1870-08		109310602	45959958	110	22102											
GRIA3	2892	broad.mit.edu	37	chrX	122532519	122532519	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgacacacgacgcaatactGgtcatagcagaagctttccg	12	9	9	11	3	1	2	1	1	0	1	2	3	2	2	1	1	3	3	1	1	4	4			TCGA-CR-6473-01A-11D-1870-08	TCGA-CR-6473-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f3396a0-a38d-4069-b65a-c4c4dd6187ad	e938fff8-12eb-4f2a-82c9-a0a98df3aabb	g.chrX:122532519G>A	uc004etq.3	+	8	1238	c.945G>A	c.(943-945)CTG>CTA	p.L315L	GRIA3_uc004etr.3_Silent_p.L315L|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Silent_p.L299L	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	315	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	ACGCAATACTGGTCATAGCAG	0.453													25	24					0	0	0	0	A	122532519	A	A	122532519	2	1	123	1	0	0	0	0	0	0	0	1	6808	1335	47	4		4	GRIA3	23	122532519	Silent	SNP	G	TCGA-CR-6473-01A-11D-1870-08	13221917	122532519	32738041	111	22103											
CAMTA1	23261	broad.mit.edu	37	chr1	7724942	7724942	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agttctccgacctgatcaacGacttcatctccgtggagggg	8	10	11	12	3	4	1	2	1	2	0	6	4	4	2	3	3	1	1	3	3	1	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:7724942G>A	uc001aoi.2	+	9	2542	c.2335G>A	c.(2335-2337)GAC>AAC	p.D779N		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CCTGATCAACGACTTCATCTC	0.647													27	313					0	0	0	0	A	7724942	A	A	7724942	3	1	124	1	0	0	0	0	1	0	0	0	2625	1058	37	1	2369	1	CAMTA1	1	7724942	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08		7724942	241525679	1	22104											
MASP2	10747	broad.mit.edu	37	chr1	11090260	11090260	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagactgggagtgatttttCtcctttggagctcgtccaga	8	13	11	9	1	1	3	0	1	1	2	4	5	2	5	2	2	1	1	2	2	0	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:11090260C>A	uc001aru.2	-	10	1291	c.1270G>T	c.(1270-1272)GAA>TAA	p.E424*		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	424	Sushi 2.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		AGTGATTTTTCTCCTTTGGAG	0.423													15	46					1.5739e-10	1.74133e-10	1	0	A	11090260	A	A	11090260	4	1	124	1	0	0	0	0	0	1	0	0	9376	922	32	2	798	2	MASP2	1	11090260	Nonsense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	3365318	11090260	238160361	2	22105											
ARHGEF10L	55160	broad.mit.edu	37	chr1	17953907	17953907	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagctggagacgctggctgAgaagctgaacgagcagaagc	13	4	16	8	2	0	5	0	2	0	4	0	8	0	5	0	2	5	5	0	2	3	0			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:17953907A>G	uc001ban.2	+	15	1652	c.1493A>G	c.(1492-1494)GAG>GGG	p.E498G	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.E459G|ARHGEF10L_uc001bao.2_Missense_Mutation_p.E459G|ARHGEF10L_uc001bap.2_Missense_Mutation_p.E459G|ARHGEF10L_uc010ocr.1_Missense_Mutation_p.E256G|ARHGEF10L_uc001baq.2_Missense_Mutation_p.E264G|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.E276G|ARHGEF10L_uc001bar.2_Missense_Mutation_p.E206G|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	498	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		ACGCTGGCTGAGAAGCTGAAC	0.627													11	42					0	0	0	0	G	17953907	G	G	17953907	3	3	124	1	0	0	0	0	1	0	0	0	895	304	11	5	1547	5	ARHGEF10L	1	17953907	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	6863647	17953907	231296714	3	22106											
C1orf173	127254	broad.mit.edu	37	chr1	75039018	75039018	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccccacagtgctgcctccccTtttccctgtactatgtcagc	5	12	6	18	0	1	0	1	0	0	0	3	0	3	0	6	0	4	2	6	0	2	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:75039018T>C	uc001dgg.2	-	14	2595	c.2376A>G	c.(2374-2376)AAA>AAG	p.K792K		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	792	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTGCCTCCCCTTTTCCCTGTA	0.522													3	149					0	0	0	0	C	75039018	C	C	75039018	2	2	124	1	0	0	0	0	0	0	0	1	2023	1606	56	5		5	C1orf173	1	75039018	Silent	SNP	T	TCGA-CR-6474-01A-11D-1870-08	57085111	75039018	174211603	4	22107											
USP33	23032	broad.mit.edu	37	chr1	78183606	78183606	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagatcatatgtcacaatttGagctggactatccttagcaa	14	12	7	8	0	2	2	2	1	0	1	3	3	3	3	1	1	2	2	1	1	6	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:78183606G>C	uc001dht.2	-	18	2304	c.1957C>G	c.(1957-1959)CAA>GAA	p.Q653E	USP33_uc001dhs.2_Missense_Mutation_p.Q374E|USP33_uc001dhu.2_Missense_Mutation_p.Q622E|USP33_uc001dhv.2_Missense_Mutation_p.Q458E|USP33_uc001dhw.2_Missense_Mutation_p.Q645E	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	653					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						GTCACAATTTGAGCTGGACTA	0.363													5	80					0	0	0	0	C	78183606	C	C	78183606	3	2	124	1	0	0	0	0	1	0	0	0	17132	1299	45	2	915	2	USP33	1	78183606	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	3144588	78183606	171067015	5	22108											
NEXN	91624	broad.mit.edu	37	chr1	78383306	78383306	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctatgtaccaaaacttggcaAgggtgatgtaaaggataagt	15	10	11	5	0	0	1	0	1	0	0	0	2	0	2	1	3	2	3	1	3	8	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:78383306A>T	uc001dic.3	+	3	380	c.83A>T	c.(82-84)AAG>ATG	p.K28M	NEXN_uc001dia.3_Missense_Mutation_p.K28M|NEXN_uc009wcb.1_Intron|NEXN_uc001dib.3_Intron|NEXN_uc001did.1_5'Flank|NEXN_uc001dif.1_5'Flank	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	28					regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		AAACTTGGCAAGGGTGATGTA	0.338													6	61					0	0	0	0	T	78383306	T	T	78383306	3	4	124	1	0	0	0	0	1	0	0	0	10409	72	3	5	89	5	NEXN	1	78383306	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	199700	78383306	170867315	6	22109											
HS2ST1	9653	broad.mit.edu	37	chr1	87558299	87558299	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttattattactttctgagaTttggagatgattatagacca	12	17	7	5	0	1	4	0	2	1	3	1	6	1	4	1	1	1	0	1	1	5	7			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:87558299T>C	uc010osk.1	+	4	920	c.535T>C	c.(535-537)TTT>CTT	p.F179L	HS2ST1_uc001dmc.3_Missense_Mutation_p.F179L|LOC339524_uc001dme.1_Missense_Mutation_p.F140L	NM_012262	NP_036394	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1 isoform	179	Lumenal (Potential).					Golgi membrane|integral to membrane				central_nervous_system(1)	1		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		CTTTCTGAGATTTGGAGATGA	0.299													7	69					0	0	0	0	C	87558299	C	C	87558299	3	2	124	1	0	0	0	0	1	0	0	0	7401	1493	52	5	549	5	HS2ST1	1	87558299	Missense_Mutation	SNP	T	TCGA-CR-6474-01A-11D-1870-08	9174993	87558299	161692322	7	22110											
PKN2	5586	broad.mit.edu	37	chr1	89271671	89271671	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaaatagatgaatcttctGaattaagagttttggatata	16	14	9	2	0	2	5	0	2	2	3	2	7	2	6	0	1	0	1	0	1	7	7			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:89271671G>C	uc001dmn.2	+	12	2116	c.1774G>C	c.(1774-1776)GAA>CAA	p.E592Q	PKN2_uc001dmm.1_3'UTR|PKN2_uc010osp.1_Missense_Mutation_p.E576Q|PKN2_uc010osq.1_Missense_Mutation_p.E435Q|PKN2_uc009wcv.2_Missense_Mutation_p.E544Q|PKN2_uc010osr.1_Missense_Mutation_p.E257Q	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	592					signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		TGAATCTTCTGAATTAAGAGT	0.388													8	50					0	0	0	0	C	89271671	C	C	89271671	3	2	124	1	0	0	0	0	1	0	0	0	12035	1291	45	2	1820	2	PKN2	1	89271671	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	1713372	89271671	159978950	8	22111											
DPYD	1806	broad.mit.edu	37	chr1	97981411	97981411	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttataaacttcaatccggcCatttctacactaatgtccac	12	14	3	12	1	2	0	1	0	1	0	4	0	4	0	3	1	2	0	3	1	6	7			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:97981411C>A	uc001drv.2	-	13	1748	c.1611G>T	c.(1609-1611)ATG>ATT	p.M537I		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	537					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TCAATCCGGCCATTTCTACAC	0.438													5	51					1.024e-07	1.10933e-07	1	0	A	97981411	A	A	97981411	3	1	124	1	0	0	0	0	1	0	0	0	4767	594	21	4	1510	4	DPYD	1	97981411	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	8709740	97981411	151269210	9	22112											
TRIM33	51592	broad.mit.edu	37	chr1	114948369	114948369	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtggtgtcaagctactctCaggactgctcaactaaaaca	13	9	9	10	0	3	0	3	0	1	0	4	1	3	1	0	3	5	2	0	3	5	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:114948369C>G	uc001eew.2	-	15	2515	c.2431G>C	c.(2431-2433)GAG>CAG	p.E811Q	TRIM33_uc010owr.1_Missense_Mutation_p.E425Q|TRIM33_uc010ows.1_Missense_Mutation_p.E443Q|TRIM33_uc001eex.2_Missense_Mutation_p.E811Q|TRIM33_uc001eey.1_Missense_Mutation_p.E6Q	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	811			E -> K (in a lung adenocarcinoma sample; somatic mutation).		negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding	p.E811K(2)		lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGCTACTCTCAGGACTGCTC	0.373			T	RET	papillary thyroid								3	92					0	0	0	0	G	114948369	G	G	114948369	3	3	124	1	0	0	0	0	1	0	0	0	16574	835	29	2	976	2	TRIM33	1	114948369	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	16966958	114948369	134302252	10	22113											
WDR3	10885	broad.mit.edu	37	chr1	118495242	118495242	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaatctctgagactttgggAgagaacaagggagcctctta	13	9	11	8	0	2	2	0	1	2	2	3	6	2	4	1	2	2	0	1	2	4	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:118495242A>G	uc010oxe.1	+	19	2174	c.2108A>G	c.(2107-2109)GAG>GGG	p.E703G	WDR3_uc001ehi.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	703	WD 13.					nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		AGACTTTGGGAGAGAACAAGG	0.463													3	122					0	0	0	0	G	118495242	G	G	118495242	3	3	124	1	0	0	0	0	1	0	0	0	17353	304	11	5	2178	5	WDR3	1	118495242	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	3546873	118495242	130755379	11	22114											
HIST2H3D	653604	broad.mit.edu	37	chr1	149784913	149784913	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcatggatggcgcacaggttCgtgtcttcgaacagccccac	8	8	12	13	3	1	0	0	0	1	0	3	2	1	1	2	3	2	3	2	3	1	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:149784913C>G	uc010pbl.1	-	1	324	c.324G>C	c.(322-324)ACG>ACC	p.T108T	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	108					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						CGCACAGGTTCGTGTCTTCGA	0.627													9	39					0	0	0	0	G	149784913	G	G	149784913	2	3	124	1	0	0	0	0	0	0	0	1	7220	871	31	3		3	HIST2H3D	1	149784913	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08	31289671	149784913	99465708	12	22115											
FCRL5	83416	broad.mit.edu	37	chr1	157497570	157497570	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtgacatcctcatgataaaaCcagtacaggattgggggaga	14	8	12	7	0	1	3	1	2	0	1	2	5	2	4	2	3	2	1	2	3	3	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:157497570C>T	uc001fqu.2	-	9	1955	c.1797G>A	c.(1795-1797)TGG>TGA	p.W599*	FCRL5_uc009wsm.2_Nonsense_Mutation_p.W599*|FCRL5_uc010phv.1_Nonsense_Mutation_p.W599*|FCRL5_uc010phw.1_Nonsense_Mutation_p.W514*	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	599	Extracellular (Potential).|Ig-like C2-type 6.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CATGATAAAACCAGTACAGGA	0.582													21	85					0	0	0	0	T	157497570	T	T	157497570	4	4	124	1	0	0	0	0	0	1	0	0	5830	508	18	4	1172	4	FCRL5	1	157497570	Nonsense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	7712657	157497570	91753051	13	22116											
CD1D	912	broad.mit.edu	37	chr1	158151354	158151354	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggagctgcagacgcacagCtggagcaacgactcggacac	11	3	15	12	3	0	1	0	0	0	1	1	5	0	4	0	4	5	5	0	4	1	0			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:158151354C>T	uc001frr.2	+	3	670	c.171C>T	c.(169-171)AGC>AGT	p.S57S	CD1D_uc009wsr.1_Silent_p.S57S|CD1D_uc009wss.2_Silent_p.S57S|CD1D_uc009wst.1_5'UTR	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	57	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					AGACGCACAGCTGGAGCAACG	0.632													50	145					0	0	0	0	T	158151354	T	T	158151354	2	4	124	1	0	0	0	0	0	0	0	1	2992	796	28	4		4	CD1D	1	158151354	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08	653784	158151354	91099267	14	22117											
KIFAP3	22920	broad.mit.edu	37	chr1	170001123	170001123	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggttttcagggtcttcatCaagtaaacaacttgttaagg	11	15	9	6	0	4	0	3	0	1	0	4	0	4	0	0	3	2	3	0	3	5	7			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:170001123C>G	uc001ggv.2	-	8	1016	c.745G>C	c.(745-747)GAT>CAT	p.D249H		NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	249					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGGTCTTCATCAAGTAAACAA	0.333													10	82					0	0	0	0	G	170001123	G	G	170001123	3	3	124	1	0	0	0	0	1	0	0	0	8350	826	29	2	1685	2	KIFAP3	1	170001123	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	11849769	170001123	79249498	15	22118											
SLC1A4	6509	broad.mit.edu	37	chr2	65245229	65245229	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgacccttccctctatgatGaagtgcattgaagagaacaa	13	9	9	10	1	1	4	0	3	1	1	2	6	2	4	2	0	2	1	2	0	5	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:65245229G>A	uc010yqa.1	+	6	1381	c.1059G>A	c.(1057-1059)ATG>ATA	p.M353I	SLC1A4_uc010ypy.1_Missense_Mutation_p.M133I|SLC1A4_uc010ypz.1_Missense_Mutation_p.M55I|SLC1A4_uc010fcv.2_Missense_Mutation_p.M353I|SLC1A4_uc002sdh.2_Missense_Mutation_p.M133I	NM_003038	NP_003029	P43007	SATT_HUMAN	solute carrier family 1, member 4 isoform 1	353					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(1)	1					L-Alanine(DB00160)	CCTCTATGATGAAGTGCATTG	0.517													36	88					0	0	0	0	A	65245229	A	A	65245229	3	1	124	1	0	0	0	0	1	0	0	0	14499	1290	45	2	1081	2	SLC1A4	2	65245229	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08		65245229	177954144	16	22119											
AFF3	3899	broad.mit.edu	37	chr2	100210748	100210748	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgttagaggatgccggttCagcctgaaagcagaaaaccg	12	8	12	9	2	1	3	1	1	0	2	1	4	1	4	3	2	4	3	3	2	4	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:100210748C>A	uc002tag.2	-	14	1611	c.1375G>T	c.(1375-1377)GAA>TAA	p.E459*	AFF3_uc002taf.2_Nonsense_Mutation_p.E484*|AFF3_uc010fiq.1_Nonsense_Mutation_p.E459*|AFF3_uc010yvr.1_Nonsense_Mutation_p.E612*|AFF3_uc002tah.1_Nonsense_Mutation_p.E484*	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	459					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GATGCCGGTTCAGCCTGAAAG	0.433													33	186					8.53417e-09	9.31001e-09	1	0	A	100210748	A	A	100210748	4	1	124	1	0	0	0	0	0	1	0	0	358	835	29	2	2349	2	AFF3	2	100210748	Nonsense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	34965519	100210748	142988625	17	22120											
ACMSD	130013	broad.mit.edu	37	chr2	135621074	135621074	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggggacgttgcccatgcAggcccctgagctggcggtca	5	8	15	13	2	2	1	1	1	1	0	2	2	2	2	3	5	3	3	3	5	0	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:135621074A>G	uc002ttz.2	+	5	426	c.359A>G	c.(358-360)CAG>CGG	p.Q120R	ACMSD_uc002tua.2_Missense_Mutation_p.Q62R	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	120					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		TTGCCCATGCAGGCCCCTGAG	0.587													3	73					0	0	0	0	G	135621074	G	G	135621074	3	3	124	1	0	0	0	0	1	0	0	0	144	188	7	5	377	5	ACMSD	2	135621074	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	35410326	135621074	107578299	18	22121											
SCN1A	6323	broad.mit.edu	37	chr2	166897962	166897962	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaacagggtgggcatttctGcctggattcttcaagttcta	8	13	10	10	0	4	0	1	0	3	0	4	1	4	1	2	3	2	2	2	3	3	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:166897962G>T	uc010zcz.1	-	13	2179	c.2161C>A	c.(2161-2163)CAG>AAG	p.Q721K	SCN1A_uc002udo.3_Missense_Mutation_p.Q601K|SCN1A_uc010fpk.2_Missense_Mutation_p.Q573K	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	732						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGGCATTTCTGCCTGGATTCT	0.323													32	56					1.36615e-20	1.56705e-20	1	0	T	166897962	T	T	166897962	3	4	124	1	0	0	0	0	1	0	0	0	13979	1328	46	4	3891	4	SCN1A	2	166897962	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	31276888	166897962	76301411	19	22122											
TTN	7273	broad.mit.edu	37	chr2	179582358	179582358	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtaaaatctgaagagttgCtacattatgaacaaaagatg	17	12	8	4	0	1	4	0	2	1	2	1	4	1	4	0	0	3	3	0	0	8	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:179582358C>T	uc010zfg.1	-	84	21735	c.21511G>A	c.(21511-21513)GCA>ACA	p.A7171T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A3832T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8098							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAGAGTTGCTACATTATGA	0.428													4	21					0	0	0	0	T	179582358	T	T	179582358	3	4	124	1	0	0	0	0	1	0	0	0	16803	797	28	4	79390	4	TTN	2	179582358	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	12684396	179582358	63617015	20	22123											
PLCL1	5334	broad.mit.edu	37	chr2	198953700	198953701	+	Frame_Shift_Del	DEL	TT	-	-																															caatactccttcagtctcacTtgtgatgaaagacagctttc																										TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:198953700_198953701delTT	uc010fsp.2	+	3	3125_3126	c.2834_2835delTT	c.(2833-2835)CTTfs	p.L945fs	PLCL1_uc002uuv.3_Frame_Shift_Del_p.L866fs	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	945					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TCAGTCTCACTTGTGATGAAAG	0.47													---	---	---								-	198953701	-	-	198953700	7	5	124	1	0	1	0	1	0	0	0	0	12094	1609	56	0	2844	0	PLCL1	2	198953700	Frame_Shift_Del	DEL	TT	TCGA-CR-6474-01A-11D-1870-08	19371342	198953700	44245673	21	22124											
SPAG16	79582	broad.mit.edu	37	chr2	215274872	215274872	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtctccctcaggtcgagttTtagctcaggcaagtggcaat	8	12	11	10	1	3	0	2	0	1	0	5	1	3	0	1	3	1	4	1	3	3	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:215274872T>C	uc002veq.2	+	16	1821	c.1729T>C	c.(1729-1731)TTA>CTA	p.L577L	SPAG16_uc002ver.2_Silent_p.L523L|SPAG16_uc010zjk.1_Silent_p.L483L|VWC2L_uc002vet.2_5'Flank|VWC2L_uc010zjl.1_5'Flank	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	577	WD 6.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGGTCGAGTTTTAGCTCAGGC	0.408													21	47					0	0	0	0	C	215274872	C	C	215274872	2	2	124	1	0	0	0	0	0	0	0	1	15044	1838	64	5		5	SPAG16	2	215274872	Silent	SNP	T	TCGA-CR-6474-01A-11D-1870-08	16321172	215274872	27924501	22	22125											
DOCK10	55619	broad.mit.edu	37	chr2	225652094	225652094	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaactccacacacatgtaTagctgctccaccaggatatt	14	9	6	12	0	0	1	0	0	0	1	2	2	2	2	3	1	3	3	3	1	4	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:225652094T>C	uc010fwz.1	-	49	5678	c.5439A>G	c.(5437-5439)CTA>CTG	p.L1813L	DOCK10_uc002vob.2_Silent_p.L1807L|DOCK10_uc002voa.2_Silent_p.L469L|DOCK10_uc002voc.2_Silent_p.L634L	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1813	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CACACATGTATAGCTGCTCCA	0.428													65	174					0	0	0	0	C	225652094	C	C	225652094	2	2	124	1	0	0	0	0	0	0	0	1	4707	1393	49	5		5	DOCK10	2	225652094	Silent	SNP	T	TCGA-CR-6474-01A-11D-1870-08	10377222	225652094	17547279	23	22126											
TRIP12	9320	broad.mit.edu	37	chr2	230663654	230663654	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactacctcccgcagtccgtGctggctcaatgttgttgctg	5	12	10	14	2	1	0	1	0	0	0	3	0	3	0	3	1	3	6	3	1	2	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:230663654G>A	uc002vpw.1	-	22	3303	c.3194C>T	c.(3193-3195)GCA>GTA	p.A1065V	TRIP12_uc002vpx.1_Missense_Mutation_p.A1113V|TRIP12_uc002vpy.1_Missense_Mutation_p.A795V|TRIP12_uc010zlz.1_RNA	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1065					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CGCAGTCCGTGCTGGCTCAAT	0.478													19	52					0	0	0	0	A	230663654	A	A	230663654	3	1	124	1	0	0	0	0	1	0	0	0	16623	1319	46	4	2864	4	TRIP12	2	230663654	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	5011560	230663654	12535719	24	22127											
HACL1	26061	broad.mit.edu	37	chr3	15609397	15609397	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaaacccaaatgcactgtCtccttccacacagatgatcc	14	8	5	14	0	1	3	0	1	1	2	4	3	3	3	4	0	2	1	4	0	3	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:15609397C>T	uc003caf.2	-	14	1523	c.1363G>A	c.(1363-1365)GAC>AAC	p.D455N	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Missense_Mutation_p.D428N|HACL1_uc011avt.1_Missense_Mutation_p.D395N|HACL1_uc003cag.2_Missense_Mutation_p.D99N|HACL1_uc011avu.1_Missense_Mutation_p.D373N|HACL1_uc010hep.2_Missense_Mutation_p.D214N	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	455	Thiamine pyrophosphate binding.	Magnesium (By similarity).			fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						AATGCACTGTCTCCTTCCACA	0.443													19	210					0	0	0	0	T	15609397	T	T	15609397	3	4	124	1	0	0	0	0	1	0	0	0	6980	913	32	2	389	2	HACL1	3	15609397	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08		15609397	182413033	25	22128											
CELSR3	1951	broad.mit.edu	37	chr3	48691215	48691215	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cacggaaatggtggggatggGccatagctgagtggataaga	12	7	17	5	1	0	2	0	1	0	1	0	5	0	5	1	6	1	1	1	6	3	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:48691215G>A	uc003cul.2	-	9	5566	c.5285C>T	c.(5284-5286)GCC>GTC	p.A1762V	CELSR3_uc003cuf.1_Missense_Mutation_p.A1832V|CELSR3_uc010hkg.2_5'Flank	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1762	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTGGGGATGGGCCATAGCTGA	0.577													4	71					0	0	0	0	A	48691215	A	A	48691215	3	1	124	1	0	0	0	0	1	0	0	0	3238	1203	42	4	4761	4	CELSR3	3	48691215	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	33081818	48691215	149331215	26	22129											
NCKIPSD	51517	broad.mit.edu	37	chr3	48719836	48719836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgggtaggctgtgctgcCgctcgaacccagctcgacac	8	7	12	14	3	0	0	0	0	0	0	2	2	0	0	2	2	5	5	2	2	3	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:48719836C>T	uc003cun.2	-	3	525	c.431G>A	c.(430-432)CGG>CAG	p.R144Q	NCKIPSD_uc003cum.2_Missense_Mutation_p.R144Q|NCKIPSD_uc010hkh.1_Missense_Mutation_p.R144Q	NM_016453	NP_057537	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain isoform	144					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTGTGCTGCCGCTCGAACCC	0.597													14	133					0	0	0	0	T	48719836	T	T	48719836	3	4	124	1	0	0	0	0	1	0	0	0	10279	652	23	1	1781	1	NCKIPSD	3	48719836	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	28621	48719836	149302594	27	22130											
PRKCD	5580	broad.mit.edu	37	chr3	53222779	53222780	+	Frame_Shift_Ins	INS	-	T	T																															gctggaccgggatggccacaINStcaagattgccgactttggg																										TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:53222779_53222780insT	uc003dgl.2	+	16	1812_1813	c.1459_1460insT	c.(1459-1461)ATCfs	p.I487fs	PRKCD_uc003dgm.2_Frame_Shift_Ins_p.I487fs	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	487	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		GGATGGCCACATCAAGATTGCC	0.564													---	---	---								T	53222780	T	T	53222779	7	5	124	1	0	1	1	0	0	0	0	0	12571	217	8	0	1513	0	PRKCD	3	53222779	Frame_Shift_Ins	INS	-	TCGA-CR-6474-01A-11D-1870-08	4502943	53222779	144799651	28	22131											
CACNA2D3	55799	broad.mit.edu	37	chr3	54913049	54913049	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttttatcattttagttgaGaaatgctatggtgaatcgaa	12	17	8	4	1	2	2	1	2	1	1	3	4	2	2	0	1	1	2	0	1	6	6			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:54913049G>C	uc003dhf.2	+	19	1763	c.1715G>C	c.(1714-1716)AGA>ACA	p.R572T	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.R478T|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Missense_Mutation_p.R306T|uc003dhk.1_Intron	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	572	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTTTAGTTGAGAAATGCTATG	0.408													3	26					0	0	0	0	C	54913049	C	C	54913049	3	2	124	1	0	0	0	0	1	0	0	0	2562	942	33	2	1789	2	CACNA2D3	3	54913049	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	1690270	54913049	143109381	29	22132											
CADM2	253559	broad.mit.edu	37	chr3	85961658	85961658	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcacgaatccctcaatgccaCccctcaggtagccatgcagg	10	7	8	16	1	3	0	3	0	0	0	4	1	4	0	5	2	3	2	5	2	3	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:85961658C>G	uc003dqj.2	+	5	1264	c.638C>G	c.(637-639)ACC>AGC	p.T213S	CADM2_uc003dqk.2_Missense_Mutation_p.T222S|CADM2_uc003dql.2_Missense_Mutation_p.T215S	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	213	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CTCAATGCCACCCCTCAGGTA	0.488													13	30					0	0	0	0	G	85961658	G	G	85961658	3	3	124	1	0	0	0	0	1	0	0	0	2579	507	18	4	727	4	CADM2	3	85961658	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	31048609	85961658	112060772	30	22133											
KALRN	8997	broad.mit.edu	37	chr3	124415027	124415027	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgtaatctgatgccccaaGacagtgggatttatacctgc	10	12	9	10	0	2	2	0	1	2	1	2	3	2	3	3	1	3	1	3	1	4	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:124415027G>C	uc003ehg.2	+	54	7751	c.7624G>C	c.(7624-7626)GAC>CAC	p.D2542H	KALRN_uc003ehk.2_Missense_Mutation_p.D845H	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2541	Ig-like C2-type.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GATGCCCCAAGACAGTGGGAT	0.463													23	154					0	0	0	0	C	124415027	C	C	124415027	3	2	124	1	0	0	0	0	1	0	0	0	8014	942	33	2	7994	2	KALRN	3	124415027	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	38453369	124415027	73607403	31	22134											
GK5	256356	broad.mit.edu	37	chr3	141884493	141884493	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttataccaattcatggagcGtttcactgctttggcccagt	8	14	9	10	1	2	0	2	0	0	0	2	1	2	1	2	2	3	3	2	2	3	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:141884493G>A	uc003euq.1	-	16	1692	c.1561C>T	c.(1561-1563)CGC>TGC	p.R521C	GK5_uc003eup.1_Missense_Mutation_p.R242C|GK5_uc010hus.1_RNA	NM_001039547	NP_001034636	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	521					glycerol metabolic process		ATP binding|glycerol kinase activity				0						TTCATGGAGCGTTTCACTGCT	0.393													19	146					0	0	0	0	A	141884493	A	A	141884493	3	1	124	1	0	0	0	0	1	0	0	0	6459	1145	40	1	32	1	GK5	3	141884493	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	17469466	141884493	56137937	32	22135											
KCNAB1	7881	broad.mit.edu	37	chr3	155838565	155838565	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctcaggggaaagccagctCagggcgcgtcaactggctct	8	6	13	14	2	4	0	3	0	1	0	4	1	4	1	2	4	3	2	2	4	2	0			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:155838565C>G	uc003far.2	+	1	229	c.165C>G	c.(163-165)CTC>CTG	p.L55L	KCNAB1_uc011bon.1_Silent_p.L55L	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	55						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AAAGCCAGCTCAGGGCGCGTC	0.557													10	61					0	0	0	0	G	155838565	G	G	155838565	2	3	124	1	0	0	0	0	0	0	0	1	8048	813	29	2		2	KCNAB1	3	155838565	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08	13954072	155838565	42183865	33	22136											
SPATA16	83893	broad.mit.edu	37	chr3	172643242	172643242	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgttggggaggaaaagatgaCcagtcaactgtctgaggcaa	13	8	14	6	0	2	3	1	2	1	1	2	5	2	5	1	4	1	2	1	4	4	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:172643242C>A	uc003fin.3	-	7	1280	c.1122G>T	c.(1120-1122)TGG>TGT	p.W374C		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	374					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GAAAAGATGACCAGTCAACTG	0.368													16	68					5.35267e-07	5.71929e-07	1	0	A	172643242	A	A	172643242	3	1	124	1	0	0	0	0	1	0	0	0	15067	508	18	4	607	4	SPATA16	3	172643242	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	16804677	172643242	25379188	34	22137											
ZNF721	170960	broad.mit.edu	37	chr4	436363	436363	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccccagtgtaaattttcttCtgttgattcaggtccgtgta	7	17	8	9	1	3	1	1	1	2	0	5	1	5	1	3	1	0	3	3	1	3	7			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:436363C>T	uc003gag.2	-	3	2584	c.1893G>A	c.(1891-1893)CAG>CAA	p.Q631Q	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Silent_p.Q663Q|ZNF721_uc010ibe.2_Silent_p.Q619Q	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	631						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AAATTTTCTTCTGTTGATTCA	0.403													29	285					0	0	0	0	T	436363	T	T	436363	2	4	124	1	0	0	0	0	0	0	0	1	18189	912	32	2		2	ZNF721	4	436363	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08		436363	190717913	35	22138											
TADA2B	93624	broad.mit.edu	37	chr4	7056454	7056454	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcagagtacgaggcagcgcgGcataaacgggagaagaggaa	15	2	17	7	4	0	3	0	0	0	3	0	6	0	4	0	4	3	4	0	4	5	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:7056454G>A	uc003gjw.3	+	2	1087	c.936G>A	c.(934-936)CGG>CGA	p.R312R	TADA2B_uc010idi.2_Silent_p.R237R	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0						AGGCAGCGCGGCATAAACGGG	0.557													3	44					0	0	0	0	A	7056454	A	A	7056454	2	1	124	1	0	0	0	0	0	0	0	1	15577	1190	42	4		4	TADA2B	4	7056454	Silent	SNP	G	TCGA-CR-6474-01A-11D-1870-08	6620091	7056454	184097822	36	22139											
SLIT2	9353	broad.mit.edu	37	chr4	20482374	20482374	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagatcagctgtattgaagAtggggcattcagggctctcc	9	10	12	10	0	3	3	2	1	1	2	4	3	3	3	2	3	1	4	2	3	2	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:20482374A>T	uc003gpr.1	+	6	707	c.503A>T	c.(502-504)GAT>GTT	p.D168V	SLIT2_uc003gps.1_Missense_Mutation_p.D168V	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	168	LRR 5.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TGTATTGAAGATGGGGCATTC	0.458													15	70					0	0	0	0	T	20482374	T	T	20482374	3	4	124	1	0	0	0	0	1	0	0	0	14804	333	12	5	525	5	SLIT2	4	20482374	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	13425920	20482374	170671902	37	22140											
BEND4	389206	broad.mit.edu	37	chr4	42145927	42145927	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcatggactgagaatggttgGagtccaggagttttcctcca	9	12	12	8	0	1	1	1	1	0	1	4	5	4	4	3	4	0	2	3	4	1	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:42145927G>T	uc003gwn.2	-	3	1152	c.572C>A	c.(571-573)TCC>TAC	p.S191Y	BEND4_uc003gwm.2_Missense_Mutation_p.S191Y|BEND4_uc011byy.1_Missense_Mutation_p.S191Y	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	191											0						AGAATGGTTGGAGTCCAGGAG	0.468													3	17					0.004672	0.00485888	1	0	T	42145927	T	T	42145927	3	4	124	1	0	0	0	0	1	0	0	0	1402	1174	41	2	1048	2	BEND4	4	42145927	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	21663553	42145927	149008349	38	22141											
WDFY3	23001	broad.mit.edu	37	chr4	85748035	85748035	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccctgtggtaataccagcTggttttagttcactgacacc	8	12	9	12	0	1	1	1	1	0	0	1	1	1	1	4	2	2	4	4	2	3	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:85748035T>A	uc003hpd.2	-	10	1464	c.1056A>T	c.(1054-1056)CCA>CCT	p.P352P	WDFY3_uc003hpf.2_Silent_p.P352P	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	352						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TAATACCAGCTGGTTTTAGTT	0.438													7	50					0	0	0	0	A	85748035	A	A	85748035	2	1	124	1	0	0	0	0	0	0	0	1	17338	1567	55	5		5	WDFY3	4	85748035	Silent	SNP	T	TCGA-CR-6474-01A-11D-1870-08	43602108	85748035	105406241	39	22142											
DKK2	27123	broad.mit.edu	37	chr4	107847051	107847051	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggccgatgatccttggtggGgactgtggcaatacctccca	8	9	13	11	1	0	1	0	1	0	0	2	3	2	2	4	5	1	1	4	5	2	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:107847051G>A	uc003hyi.2	-	2	983	c.278C>T	c.(277-279)CCC>CTC	p.P93L	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Missense_Mutation_p.P93L	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	93	DKK-type Cys-1.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		TCCTTGGTGGGGACTGTGGCA	0.512													3	88					0	0	0	0	A	107847051	A	A	107847051	3	1	124	1	0	0	0	0	1	0	0	0	4567	1232	43	4	513	4	DKK2	4	107847051	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	22099016	107847051	83307225	40	22143											
NDST4	64579	broad.mit.edu	37	chr4	115773929	115773929	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttggtaagtggtcacaagTtttctctctggaccagatgt	8	16	10	7	0	3	1	1	0	2	1	4	2	3	2	1	3	0	2	1	3	2	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:115773929T>G	uc003ibu.2	-	8	2447	c.1768A>C	c.(1768-1770)ACT>CCT	p.T590P	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	590	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TGGTCACAAGTTTTCTCTCTG	0.348													9	28					0	0	0	0	G	115773929	G	G	115773929	3	3	124	1	0	0	0	0	1	0	0	0	10312	1725	60	5	878	5	NDST4	4	115773929	Missense_Mutation	SNP	T	TCGA-CR-6474-01A-11D-1870-08	7926878	115773929	75380347	41	22144											
USP53	54532	broad.mit.edu	37	chr4	120213687	120213687	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttttcacgttgataactCtgcttctgggaagagagtga	9	13	11	8	1	3	3	1	2	2	1	3	5	3	4	1	1	2	2	1	1	2	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:120213687C>G	uc003ics.3	+	18	3609	c.2543C>G	c.(2542-2544)TCT>TGT	p.S848C	USP53_uc003icr.3_Missense_Mutation_p.S848C|USP53_uc003icu.3_Missense_Mutation_p.S471C	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	848					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						GTTGATAACTCTGCTTCTGGG	0.393													6	43					0	0	0	0	G	120213687	G	G	120213687	3	3	124	1	0	0	0	0	1	0	0	0	17152	913	32	2	2601	2	USP53	4	120213687	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	4439758	120213687	70940589	42	22145											
CCNA2	890	broad.mit.edu	37	chr4	122742139	122742139	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcagagaacctttacctccaTttccctaaggtatgtgtgaa	11	13	7	10	0	1	2	1	1	0	1	3	3	3	2	4	1	2	1	4	1	5	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:122742139T>G	uc003iec.3	-	3	870	c.565A>C	c.(565-567)ATG>CTG	p.M189L		NM_001237	NP_001228	P20248	CCNA2_HUMAN	cyclin A	189					cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			ovary(1)	1						TTTACCTCCATTTCCCTAAGG	0.313													9	77					0	0	0	0	G	122742139	G	G	122742139	3	3	124	1	0	0	0	0	1	0	0	0	2925	1493	52	5	757	5	CCNA2	4	122742139	Missense_Mutation	SNP	T	TCGA-CR-6474-01A-11D-1870-08	2528452	122742139	68412137	43	22146											
MYO10	4651	broad.mit.edu	37	chr5	16761646	16761646	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccaagatacctcggacatCatattgcacctagttttaat	12	13	5	11	1	1	1	1	0	0	1	3	2	2	2	3	1	2	2	3	1	5	6			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:16761646C>T	uc003jft.3	-	17	2134	c.1666G>A	c.(1666-1668)GAT>AAT	p.D556N	MYO10_uc010itx.2_Missense_Mutation_p.D179N	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	556	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CCTCGGACATCATATTGCACC	0.383													18	107					0	0	0	0	T	16761646	T	T	16761646	3	4	124	1	0	0	0	0	1	0	0	0	10115	826	29	2	4610	2	MYO10	5	16761646	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08		16761646	164153614	44	22147											
EGFLAM	133584	broad.mit.edu	37	chr5	38464020	38464020	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctcacttcaccctgtccaccGattaccacatttccctcgtg	7	12	4	18	2	2	0	2	0	0	0	5	1	4	0	5	0	1	0	5	0	1	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:38464020G>C	uc003jlc.1	+	23	3310	c.2986G>C	c.(2986-2988)GAT>CAT	p.D996H	EGFLAM_uc003jlb.1_Missense_Mutation_p.D988H|EGFLAM_uc003jle.1_Missense_Mutation_p.D754H|EGFLAM_uc003jlf.1_Missense_Mutation_p.D354H|EGFLAM_uc003jlg.1_Missense_Mutation_p.D131H|EGFLAM_uc003jlh.1_Missense_Mutation_p.D78H	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	996	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					CCTGTCCACCGATTACCACAT	0.512													11	54					0	0	0	0	C	38464020	C	C	38464020	3	2	124	1	0	0	0	0	1	0	0	0	4988	1058	37	3	3062	3	EGFLAM	5	38464020	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	21702374	38464020	142451240	45	22148											
FBXO4	26272	broad.mit.edu	37	chr5	41929884	41929884	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacttcttttttacactccCtgatcattcagaatgaacca	11	15	3	12	0	4	3	3	2	1	1	5	3	5	3	2	0	2	0	2	0	3	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:41929884C>T	uc003jmq.2	+	3	567	c.511C>T	c.(511-513)CTG>TTG	p.L171L	FBXO4_uc003jmp.2_Silent_p.L171L|FBXO4_uc003jmr.2_Silent_p.L171L	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	171					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				TTTACACTCCCTGATCATTCA	0.403													15	100					0	0	0	0	T	41929884	T	T	41929884	2	4	124	1	0	0	0	0	0	0	0	1	5780	680	24	4		4	FBXO4	5	41929884	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08	3465864	41929884	138985376	46	22149											
DDX46	9879	broad.mit.edu	37	chr5	134121257	134121257	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agtggtctgtgtttacggagGaacaggaatcagtgagcagg	11	9	16	5	1	2	1	1	1	1	0	2	4	2	4	0	5	3	2	0	5	3	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:134121257G>C	uc003kzw.2	+	11	1613	c.1445G>C	c.(1444-1446)GGA>GCA	p.G482A	DDX46_uc003kzv.1_RNA	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	482	Helicase ATP-binding.				mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTTACGGAGGAACAGGAATC	0.363													8	68					0	0	0	0	C	134121257	C	C	134121257	3	2	124	1	0	0	0	0	1	0	0	0	4381	1174	41	2	1487	2	DDX46	5	134121257	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	92191373	134121257	46794003	47	22150											
PCDHGB7	56099	broad.mit.edu	37	chr5	140798773	140798773	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgacgtcaatgacaacgcGccggttttcggacagtcagc	10	8	11	12	5	2	2	2	2	0	0	3	3	2	3	1	2	2	1	1	2	2	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:140798773G>A	uc003lkn.1	+	1	1492	c.1347G>A	c.(1345-1347)GCG>GCA	p.A449A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Silent_p.A449A|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	449	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACAACGCGCCGGTTTTCG	0.572													4	49					0	0	0	0	A	140798773	A	A	140798773	2	1	124	1	0	0	0	0	0	0	0	1	11622	1074	38	1		1	PCDHGB7	5	140798773	Silent	SNP	G	TCGA-CR-6474-01A-11D-1870-08	6677516	140798773	40116487	48	22151											
AFAP1L1	134265	broad.mit.edu	37	chr5	148715178	148715178	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactgcaaataaaccccagAacagcgttccagagcaacct	17	5	6	13	1	0	2	0	0	0	2	1	2	1	2	4	0	7	3	4	0	6	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:148715178A>T	uc003lqh.2	+	18	2307	c.2176A>T	c.(2176-2178)AAC>TAC	p.N726Y	AFAP1L1_uc010jgy.2_Intron|AFAP1L1_uc003lqi.1_Missense_Mutation_p.N341Y	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	726							protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAAACCCCAGAACAGCGTTCC	0.488													5	93					0	0	0	0	T	148715178	T	T	148715178	3	4	124	1	0	0	0	0	1	0	0	0	354	246	9	5	2246	5	AFAP1L1	5	148715178	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	7916405	148715178	32200082	49	22152											
ATP10B	23120	broad.mit.edu	37	chr5	160063305	160063305	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcaaaggtcccattccAgatgctgtgacctgagagga	10	11	10	10	0	2	3	1	2	1	2	4	5	4	4	3	2	1	1	3	2	1	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:160063305A>T	uc003lym.1	-	11	1859	c.1012T>A	c.(1012-1014)TGG>AGG	p.W338R	ATP10B_uc003lyp.2_Missense_Mutation_p.W338R|ATP10B_uc011deg.1_Missense_Mutation_p.W382R|ATP10B_uc003lyn.2_5'Flank|ATP10B_uc003lyo.2_Missense_Mutation_p.W310R	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	338	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCCCATTCCAGATGCTGTGA	0.493													3	58					0	0	0	0	T	160063305	T	T	160063305	3	4	124	1	0	0	0	0	1	0	0	0	1119	188	7	5	3437	5	ATP10B	5	160063305	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	11348127	160063305	20851955	50	22153											
NRSN1	140767	broad.mit.edu	37	chr6	24145830	24145830	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggattgactgttctggcaGtgggctttcttgtgcccccc	3	14	12	12	1	2	1	0	1	2	0	3	2	2	2	3	3	1	3	3	3	0	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:24145830G>T	uc010jpq.1	+	4	481	c.244G>T	c.(244-246)GTG>TTG	p.V82L		NM_080723	NP_542454	Q8IZ57	NRSN1_HUMAN	neurensin 1	82	Helical; (Potential).				nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle					0						TGTTCTGGCAGTGGGCTTTCT	0.478													14	149					4.36969e-10	4.80051e-10	1	0	T	24145830	T	T	24145830	3	4	124	1	0	0	0	0	1	0	0	0	10716	1029	36	4	250	4	NRSN1	6	24145830	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08		24145830	146969237	51	22154											
SLC35B2	347734	broad.mit.edu	37	chr6	44222789	44222789	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagggccccctgttctagcAgtgagcccactgtgaagagg	8	8	14	11	0	1	3	0	2	1	1	1	3	1	3	3	2	2	3	3	2	3	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:44222789A>T	uc003oxd.2	-	4	1089	c.953T>A	c.(952-954)CTG>CAG	p.L318Q	SLC35B2_uc011dvt.1_Missense_Mutation_p.L221Q|SLC35B2_uc011dvu.1_Missense_Mutation_p.L185Q	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	318	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTGTTCTAGCAGTGAGCCCAC	0.557													17	37					0	0	0	0	T	44222789	T	T	44222789	3	4	124	1	0	0	0	0	1	0	0	0	14640	188	7	5	349	5	SLC35B2	6	44222789	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	20076959	44222789	126892278	52	22155											
HCRTR2	3062	broad.mit.edu	37	chr6	55113547	55113547	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacctgccttccagccacaCtggtcgtggatatcactgag	8	10	9	14	1	2	1	2	1	0	0	4	2	3	2	4	2	2	0	4	2	1	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:55113547C>A	uc003pcl.2	+	2	649	c.334C>A	c.(334-336)CTG>ATG	p.L112M	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.L47M	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	112	Extracellular (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TCCAGCCACACTGGTCGTGGA	0.443													18	168					0.000132079	0.000140165	1	0	A	55113547	A	A	55113547	3	1	124	1	0	0	0	0	1	0	0	0	7041	564	20	4	340	4	HCRTR2	6	55113547	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	10890758	55113547	116001520	53	22156											
MDN1	23195	broad.mit.edu	37	chr6	90425374	90425374	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtaagagatacaaatacctGaaattgggatttggtgttat	14	14	10	3	0	0	2	0	1	0	1	0	4	0	3	1	2	2	2	1	2	6	6			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:90425374G>A	uc003pnn.1	-	45	6974	c.6858C>T	c.(6856-6858)TTC>TTT	p.F2286F		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2286					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACAAATACCTGAAATTGGGAT	0.403													10	113					0	0	0	0	A	90425374	A	A	90425374	2	1	124	1	0	0	0	0	0	0	0	1	9468	1281	45	2		2	MDN1	6	90425374	Silent	SNP	G	TCGA-CR-6474-01A-11D-1870-08	35311827	90425374	80689693	54	22157											
FAM184A	79632	broad.mit.edu	37	chr6	119324126	119324126	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctgcatttttctctcgatCtttcaactgcaaaagttgag	9	16	7	9	1	3	1	1	1	2	0	5	2	3	1	0	0	4	4	0	0	3	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:119324126C>G	uc003pyj.2	-	9	2374	c.2026G>C	c.(2026-2028)GAT>CAT	p.D676H	FAM184A_uc003pyk.3_Missense_Mutation_p.D556H|FAM184A_uc003pyl.3_Missense_Mutation_p.D556H	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	676	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TTCTCTCGATCTTTCAACTGC	0.358													11	89					0	0	0	0	G	119324126	G	G	119324126	3	3	124	1	0	0	0	0	1	0	0	0	5539	913	32	2	1436	2	FAM184A	6	119324126	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	28898752	119324126	51790941	55	22158											
L3MBTL3	84456	broad.mit.edu	37	chr6	130370430	130370430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctgtgttgttgctagtttCgggtaaatgagtttggagcc	6	16	14	5	1	0	1	0	1	0	0	1	2	0	2	1	2	3	7	1	2	3	6			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:130370430C>T	uc003qbt.2	+	4	276	c.106C>T	c.(106-108)CGG>TGG	p.R36W	L3MBTL3_uc003qbu.2_Missense_Mutation_p.R36W	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	36					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		TTGCTAGTTTCGGGTAAATGA	0.368													8	25					0	0	0	0	T	130370430	T	T	130370430	3	4	124	1	0	0	0	0	1	0	0	0	8633	875	31	1	112	1	L3MBTL3	6	130370430	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	11046304	130370430	40744637	56	22159											
BCLAF1	9774	broad.mit.edu	37	chr6	136597106	136597106	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagacttttctcgtgcatcCagattcttgtgtagaggggg	7	14	13	7	1	2	3	0	0	2	3	4	3	3	3	1	2	1	3	1	2	2	6			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:136597106C>G	uc003qgx.1	-	5	1810	c.1557G>C	c.(1555-1557)CTG>CTC	p.L519L	BCLAF1_uc003qgw.1_Silent_p.L346L|BCLAF1_uc003qgy.1_Silent_p.L517L|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.L517L	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	519					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTCGTGCATCCAGATTCTTGT	0.423													12	310					0	0	0	0	G	136597106	G	G	136597106	2	3	124	1	0	0	0	0	0	0	0	1	1385	581	21	4		4	BCLAF1	6	136597106	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08	6226676	136597106	34517961	57	22160											
GRM1	2911	broad.mit.edu	37	chr6	146480529	146480529	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgctttcaaagagctggctgCccaggaaggcctctgtatcg	8	9	12	12	2	2	1	1	0	1	1	3	2	2	2	2	3	2	4	2	3	3	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:146480529C>T	uc010khw.1	+	3	1216	c.746C>T	c.(745-747)GCC>GTC	p.A249V	GRM1_uc010khu.1_Missense_Mutation_p.A249V|GRM1_uc010khv.1_Missense_Mutation_p.A249V|GRM1_uc003qll.2_Missense_Mutation_p.A249V|GRM1_uc011edz.1_Missense_Mutation_p.A249V|GRM1_uc011eea.1_Missense_Mutation_p.A249V	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	249	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GAGCTGGCTGCCCAGGAAGGC	0.507													9	82					0	0	0	0	T	146480529	T	T	146480529	3	4	124	1	0	0	0	0	1	0	0	0	6835	739	26	4	752	4	GRM1	6	146480529	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	9883423	146480529	24634538	58	22161											
INTS1	26173	broad.mit.edu	37	chr7	1528988	1528988	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcgcactcacttggtcatCaccatctccatgagcatctt	8	12	7	14	1	5	1	3	1	2	0	6	1	5	1	2	1	2	2	2	1	0	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:1528988C>T	uc003skn.2	-	18	2411	c.2310G>A	c.(2308-2310)GTG>GTA	p.V770V	INTS1_uc003skp.1_Silent_p.V117V	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	770					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		ACTTGGTCATCACCATCTCCA	0.682													4	17					0	0	0	0	T	1528988	T	T	1528988	2	4	124	1	0	0	0	0	0	0	0	1	7814	813	29	2		2	INTS1	7	1528988	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08		1528988	157609675	59	22162											
CLIP2	7461	broad.mit.edu	37	chr7	73790521	73790521	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggtggcgggcctgaaggAcaaggttcagcaggccacca	10	4	17	10	1	1	1	1	1	0	0	1	3	1	3	3	7	1	2	3	7	2	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:73790521A>G	uc003uam.2	+	10	2117	c.1790A>G	c.(1789-1791)GAC>GGC	p.D597G	CLIP2_uc003uan.2_Missense_Mutation_p.D562G|CLIP2_uc003uao.2_5'UTR	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	597	Potential.					microtubule associated complex				skin(3)	3						GGCCTGAAGGACAAGGTTCAG	0.612													5	21					0	0	0	0	G	73790521	G	G	73790521	3	3	124	1	0	0	0	0	1	0	0	0	3548	275	10	5	1824	5	CLIP2	7	73790521	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	72261533	73790521	85348142	60	22163											
CLIP2	7461	broad.mit.edu	37	chr7	73795176	73795176	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagaggagacgatcaggaCgaaggaaactgtggagggtg	13	6	17	5	2	2	2	2	0	0	2	2	8	2	5	0	5	1	0	0	5	2	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:73795176C>T	uc003uam.2	+	11	2789	c.2462C>T	c.(2461-2463)ACG>ATG	p.T821M	CLIP2_uc003uan.2_Missense_Mutation_p.T786M|CLIP2_uc003uao.2_Missense_Mutation_p.T215M	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	821	Potential.					microtubule associated complex				skin(3)	3						ACGATCAGGACGAAGGAAACT	0.602													26	85					0	0	0	0	T	73795176	T	T	73795176	3	4	124	1	0	0	0	0	1	0	0	0	3548	536	19	1	2500	1	CLIP2	7	73795176	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	4655	73795176	85343487	61	22164											
TRPV5	56302	broad.mit.edu	37	chr7	142625874	142625874	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggctgcaggtggtccccaTgtccatcgtaggacagcagc	7	7	15	12	1	0	0	0	0	0	0	3	1	2	1	3	5	3	4	3	5	1	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:142625874T>G	uc003wby.1	-	6	938	c.674A>C	c.(673-675)CAT>CCT	p.H225P	TRPV5_uc003wbz.2_Missense_Mutation_p.H225P	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	225	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GTGGTCCCCATGTCCATCGTA	0.567													4	92					0	0	0	0	G	142625874	G	G	142625874	3	3	124	1	0	0	0	0	1	0	0	0	16666	1464	51	5	1555	5	TRPV5	7	142625874	Missense_Mutation	SNP	T	TCGA-CR-6474-01A-11D-1870-08	68830698	142625874	16512789	62	22165											
OR2F2	135948	broad.mit.edu	37	chr7	143632931	143632931	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaggctgccatcatggtgtcTagcattgttcttctgatgac	7	14	11	9	0	4	2	1	2	3	0	4	3	4	2	1	2	2	3	1	2	1	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:143632931T>G	uc011ktv.1	+	1	606	c.606T>G	c.(604-606)TCT>TCG	p.S202S		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					TCATGGTGTCTAGCATTGTTC	0.478													15	56					0	0	0	0	G	143632931	G	G	143632931	2	3	124	1	0	0	0	0	0	0	0	1	11051	1509	53	5		5	OR2F2	7	143632931	Silent	SNP	T	TCGA-CR-6474-01A-11D-1870-08	1007057	143632931	15505732	63	22166											
POTEA	340441	broad.mit.edu	37	chr8	43147925	43147925	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaaagggacaagaagaagAggtaaccgggcctggggctg	15	3	16	7	1	0	3	0	0	0	3	0	4	0	4	2	5	1	2	2	5	6	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr8:43147925A>G	uc003xpz.1	+	1	341	c.298A>G	c.(298-300)AGG>GGG	p.R100G	POTEA_uc003xqa.1_Missense_Mutation_p.R100G	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	100	ANK 1.									ovary(1)	1						CAAGAAGAAGAGGTAACCGGG	0.627													3	56					0	0	0	0	G	43147925	G	G	43147925	3	3	124	1	0	0	0	0	1	0	0	0	12316	318	11	5	300	5	POTEA	8	43147925	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08		43147925	103216097	64	22167											
ATP6V1C1	528	broad.mit.edu	37	chr8	104054601	104054601	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtcttggttggcttgtcaGatgaactggctaaactggat	9	14	12	6	0	2	2	1	1	1	1	2	3	2	3	0	4	2	3	0	4	3	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr8:104054601G>A	uc003ykz.3	+	3	411	c.166G>A	c.(166-168)GAT>AAT	p.D56N	ATP6V1C1_uc010mbz.2_5'UTR|ATP6V1C1_uc003yla.2_Missense_Mutation_p.D56N|ATP6V1C1_uc011lhl.1_Intron	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	56					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			TGGCTTGTCAGATGAACTGGC	0.363													12	128					0	0	0	0	A	104054601	A	A	104054601	3	1	124	1	0	0	0	0	1	0	0	0	1182	942	33	2	172	2	ATP6V1C1	8	104054601	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	60906676	104054601	42309421	65	22168											
MCART1	92014	broad.mit.edu	37	chr9	37887716	37887716	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccccaagagatgagggaccGatggtaattcagatgggcac	12	6	14	9	1	1	3	1	1	0	2	1	6	1	4	3	3	0	2	3	3	2	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr9:37887716G>A	uc004aau.2	-	3	1576	c.832C>T	c.(832-834)CGG>TGG	p.R278W	MCART1_uc004aar.1_Intron|MCART1_uc004aaq.1_Intron|uc004aat.1_5'Flank|MCART1_uc004aav.2_Missense_Mutation_p.R278W	NM_033412	NP_219480	Q9H1U9	MCAR1_HUMAN	mitochondrial carrier triple repeat 1	278	Helical; Name=6; (Potential).|Solcar 3.				transport	integral to membrane|mitochondrial inner membrane				ovary(2)|breast(1)	3				GBM - Glioblastoma multiforme(29;0.00559)|Lung(182;0.0422)		ATGAGGGACCGATGGTAATTC	0.393													10	48					0	0	0	0	A	37887716	A	A	37887716	3	1	124	1	0	0	0	0	1	0	0	0	9422	1057	37	1	65	1	MCART1	9	37887716	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08		37887716	103325715	66	22169											
GPR107	57720	broad.mit.edu	37	chr9	132887236	132887236	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaacttttcagacattattAcgtcttggtaagtaaaaaaa	17	13	6	5	1	2	1	1	0	1	1	2	2	2	1	0	1	2	2	0	1	8	7			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr9:132887236A>G	uc004bze.2	+	17	1720	c.1493A>G	c.(1492-1494)TAC>TGC	p.Y498C	GPR107_uc004bzb.2_Missense_Mutation_p.Y261C|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.Y469C|GPR107_uc004bzd.2_Missense_Mutation_p.Y450C	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	498						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				AGACATTATTACGTCTTGGTA	0.308													2	3					0	0	0	0	G	132887236	G	G	132887236	3	3	124	1	0	0	0	0	1	0	0	0	6661	391	14	5	1559	5	GPR107	9	132887236	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	94999520	132887236	8326195	67	22170											
MYO3A	53904	broad.mit.edu	37	chr10	26482144	26482144	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttcttataggtgtctgtaaAggagaggagccaaaaatatt	14	13	10	4	0	2	1	0	0	2	1	2	3	2	2	1	3	1	1	1	3	7	6			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:26482144A>T	uc001isn.2	+	32	4809	c.4449A>T	c.(4447-4449)AAA>AAT	p.K1483N	MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1483					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GTGTCTGTAAAGGAGAGGAGC	0.333													3	30					0	0	0	0	T	26482144	T	T	26482144	3	4	124	1	0	0	0	0	1	0	0	0	10129	69	3	5	4567	5	MYO3A	10	26482144	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08		26482144	109052603	68	22171											
PARD3	56288	broad.mit.edu	37	chr10	34671564	34671564	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	attctgaggtgccgaggctgGagcggatggtggttttcccg	5	11	17	8	3	1	1	0	1	1	0	2	4	2	3	2	6	2	2	2	6	0	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:34671564G>C	uc010qej.1	-	9	1303	c.1303C>G	c.(1303-1305)CCA>GCA	p.P435A	PARD3_uc010qek.1_Missense_Mutation_p.P435A|PARD3_uc010qel.1_Missense_Mutation_p.P435A|PARD3_uc010qem.1_Missense_Mutation_p.P435A|PARD3_uc010qen.1_Missense_Mutation_p.P435A|PARD3_uc010qeo.1_Missense_Mutation_p.P435A|PARD3_uc010qep.1_Missense_Mutation_p.P391A|PARD3_uc010qeq.1_Missense_Mutation_p.P391A|PARD3_uc001ixo.1_Missense_Mutation_p.P165A|PARD3_uc001ixp.1_Missense_Mutation_p.P300A|PARD3_uc001ixq.1_Missense_Mutation_p.P435A|PARD3_uc001ixr.1_Missense_Mutation_p.P435A|PARD3_uc001ixt.1_Missense_Mutation_p.P256A|PARD3_uc001ixu.1_Missense_Mutation_p.P391A|PARD3_uc001ixs.1_Missense_Mutation_p.P88A	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	435					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				GCCGAGGCTGGAGCGGATGGT	0.502													3	75					0	0	0	0	C	34671564	C	C	34671564	3	2	124	1	0	0	0	0	1	0	0	0	11497	1174	41	2	2870	2	PARD3	10	34671564	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	8189420	34671564	100863183	69	22172											
ARID5B	84159	broad.mit.edu	37	chr10	63759919	63759919	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccggtaccgctcgatgcTgaaacgcatccaggataagc	10	7	11	13	4	0	1	0	1	0	0	2	3	1	2	3	2	5	4	3	2	3	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:63759919T>C	uc001jlt.1	+	4	598	c.572T>C	c.(571-573)CTG>CCG	p.L191P	ARID5B_uc010qil.1_Missense_Mutation_p.L191P	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	191					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CGCTCGATGCTGAAACGCATC	0.532													3	67					0	0	0	0	C	63759919	C	C	63759919	3	2	124	1	0	0	0	0	1	0	0	0	922	1580	55	5	586	5	ARID5B	10	63759919	Missense_Mutation	SNP	T	TCGA-CR-6474-01A-11D-1870-08	29088355	63759919	71774828	70	22173											
SFXN4	119559	broad.mit.edu	37	chr10	120917410	120917410	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtttccattgatgctgttGaacgctgccatgtaggcaca	8	13	10	10	1	0	2	0	2	0	0	1	2	1	2	2	1	3	6	2	1	2	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:120917410G>A	uc001leb.2	-	8	489	c.444C>T	c.(442-444)TTC>TTT	p.F148F	SFXN4_uc001ldy.2_Silent_p.F32F|SFXN4_uc001ldz.2_Silent_p.F32F|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	148	Helical; (Potential).				iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		TGATGCTGTTGAACGCTGCCA	0.418													9	60					0	0	0	0	A	120917410	A	A	120917410	2	1	124	1	0	0	0	0	0	0	0	1	14262	1281	45	2		2	SFXN4	10	120917410	Silent	SNP	G	TCGA-CR-6474-01A-11D-1870-08	57157491	120917410	14617337	71	22174											
MKI67	4288	broad.mit.edu	37	chr10	129907526	129907526	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaggctctgtctcagtatCtgaagtttttgtctccagag	8	15	10	8	0	4	3	1	2	4	1	6	3	4	3	1	1	0	3	1	1	3	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:129907526C>G	uc001lke.2	-	13	2773	c.2578G>C	c.(2578-2580)GAT>CAT	p.D860H	MKI67_uc001lkf.2_Missense_Mutation_p.D500H|MKI67_uc009yav.1_Missense_Mutation_p.D435H|MKI67_uc009yaw.1_Missense_Mutation_p.D10H	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	860					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTCTCAGTATCTGAAGTTTTT	0.433													18	171					0	0	0	0	G	129907526	G	G	129907526	3	3	124	1	0	0	0	0	1	0	0	0	9651	913	32	2	7204	2	MKI67	10	129907526	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	8990116	129907526	5627221	72	22175											
EBF3	253738	broad.mit.edu	37	chr10	131761669	131761669	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccacaaaagcggtcctttCaatctccaccggctgcccct	8	9	7	17	2	2	0	1	0	1	0	5	0	4	0	6	2	2	1	6	2	3	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:131761669C>A	uc001lki.1	-	2	312	c.253G>T	c.(253-255)GAA>TAA	p.E85*	EBF3_uc010qur.1_Nonsense_Mutation_p.E71*	NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	85					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GCGGTCCTTTCAATCTCCACC	0.557													26	122					1.39806e-14	1.58041e-14	1	0	A	131761669	A	A	131761669	4	1	124	1	0	0	0	0	0	1	0	0	4904	835	29	2	1462	2	EBF3	10	131761669	Nonsense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	1854143	131761669	3773078	73	22176											
MUC6	4588	broad.mit.edu	37	chr11	1028716	1028716	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggggcgcagctggaccacGagctccagcccgaagctggt	8	5	15	13	3	0	0	0	0	0	0	1	3	1	1	3	4	4	4	3	4	1	0			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr11:1028716G>T	uc001lsw.2	-	13	1572	c.1521C>A	c.(1519-1521)CTC>CTA	p.L507L		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	507	VWFD 2.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCTGGACCACGAGCTCCAGCC	0.642													4	19					0.00024832	0.000261743	1	0	T	1028716	T	T	1028716	2	4	124	1	0	0	0	0	0	0	0	1	10033	1045	37	3		3	MUC6	11	1028716	Silent	SNP	G	TCGA-CR-6474-01A-11D-1870-08		1028716	133977800	74	22177											
LRRC4C	57689	broad.mit.edu	37	chr11	40137506	40137506	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccccaatttcaatggttcTgatatggttcctactcaact	10	14	6	11	0	3	1	2	1	1	0	4	1	4	1	3	2	3	2	3	2	5	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr11:40137506T>G	uc001mxa.1	-	2	2301	c.337A>C	c.(337-339)AGA>CGA	p.R113R	LRRC4C_uc001mxc.1_Silent_p.R109R|LRRC4C_uc001mxd.1_Silent_p.R109R|LRRC4C_uc001mxb.1_Silent_p.R109R	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	113	LRR 2.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TCAATGGTTCTGATATGGTTC	0.438													16	45					0	0	0	0	G	40137506	G	G	40137506	2	3	124	1	0	0	0	0	0	0	0	1	9058	1588	55	5		5	LRRC4C	11	40137506	Silent	SNP	T	TCGA-CR-6474-01A-11D-1870-08	39108790	40137506	94869010	75	22178											
OR5M8	219484	broad.mit.edu	37	chr11	56258421	56258421	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acataaggcaccgtgatgagGaaggagcacacactcttgga	14	6	12	9	1	1	2	0	2	1	0	1	5	1	5	1	4	1	2	1	4	2	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr11:56258421G>T	uc001nix.1	-	1	426	c.426C>A	c.(424-426)TTC>TTA	p.F142L		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					CCGTGATGAGGAAGGAGCACA	0.512													19	85					5.03518e-11	5.61063e-11	1	0	T	56258421	T	T	56258421	3	4	124	1	0	0	0	0	1	0	0	0	11230	1165	41	2	513	2	OR5M8	11	56258421	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	16120915	56258421	78748095	76	22179											
CPSF7	79869	broad.mit.edu	37	chr11	61196680	61196680	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaactcctcgtcagcatataTatcaatcaagtccactcctt	12	12	4	13	1	3	0	3	0	0	0	7	1	6	0	3	0	2	1	3	0	6	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr11:61196680T>A	uc001nrq.2	-	2	162	c.28A>T	c.(28-30)ATA>TTA	p.I10L	SDHAF2_uc001nrt.2_5'Flank|CPSF7_uc001nro.2_Missense_Mutation_p.I10L|CPSF7_uc001nrp.2_Missense_Mutation_p.I53L|CPSF7_uc001nrr.2_Missense_Mutation_p.I10L|CPSF7_uc001nrs.1_5'UTR|CPSF7_uc009ynp.2_Missense_Mutation_p.I10L	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	10					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TCAGCATATATATCAATCAAG	0.478													35	212					0	0	0	0	A	61196680	A	A	61196680	3	1	124	1	0	0	0	0	1	0	0	0	3845	1406	49	5	1419	5	CPSF7	11	61196680	Missense_Mutation	SNP	T	TCGA-CR-6474-01A-11D-1870-08	4938259	61196680	73809836	77	22180											
SLC3A2	6520	broad.mit.edu	37	chr11	62655847	62655847	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcctttccttgttccggcgGctgagtgaccagcggagtaa	6	11	12	12	3	0	2	0	2	0	0	3	3	3	3	4	3	1	3	4	3	1	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr11:62655847G>T	uc001nwd.2	+	12	1799	c.1575G>T	c.(1573-1575)CGG>CGT	p.R525R	SLC3A2_uc001nwb.2_Silent_p.R556R|SLC3A2_uc001nwc.2_Silent_p.R526R|SLC3A2_uc001nwe.2_Silent_p.R494R|SLC3A2_uc001nwf.2_Silent_p.R463R|SLC3A2_uc001nwg.2_Silent_p.R424R	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	525	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						TGTTCCGGCGGCTGAGTGACC	0.587													22	69					1.50039e-11	1.68389e-11	1	0	T	62655847	T	T	62655847	2	4	124	1	0	0	0	0	0	0	0	1	14691	1190	42	4		4	SLC3A2	11	62655847	Silent	SNP	G	TCGA-CR-6474-01A-11D-1870-08	1459167	62655847	72350669	78	22181											
LIMA1	51474	broad.mit.edu	37	chr12	50571764	50571764	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtggtctgtgcccaaagcCttcatcatagttgcccttag	7	13	10	11	0	3	0	2	0	1	0	3	0	3	0	3	1	3	1	3	1	3	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr12:50571764C>T	uc001rwj.3	-	11	1537	c.1363G>A	c.(1363-1365)GGC>AGC	p.G455S	LIMA1_uc001rwg.3_Missense_Mutation_p.G153S|LIMA1_uc001rwh.3_Missense_Mutation_p.G294S|LIMA1_uc001rwi.3_Missense_Mutation_p.G296S|LIMA1_uc001rwk.3_Missense_Mutation_p.G456S|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	455					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						TGCCCAAAGCCTTCATCATAG	0.418													8	163					0	0	0	0	T	50571764	T	T	50571764	3	4	124	1	0	0	0	0	1	0	0	0	8837	681	24	4	920	4	LIMA1	12	50571764	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08		50571764	83280131	79	22182											
CEP290	80184	broad.mit.edu	37	chr12	88535027	88535027	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctgccagttcttcttgacGgggcaggtcatctgggtcaa	7	12	12	10	1	6	1	2	1	4	0	6	1	6	1	1	4	1	2	1	4	1	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr12:88535027G>A	uc001tar.2	-	2	402	c.58C>T	c.(58-60)CGT>TGT	p.R20C	CEP290_uc009zsl.1_5'Flank|TMTC3_uc009zsm.2_5'Flank|TMTC3_uc001tau.2_5'Flank	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	20					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						TCTTCTTGACGGGGCAGGTCA	0.313													14	27					0	0	0	0	A	88535027	A	A	88535027	3	1	124	1	0	0	0	0	1	0	0	0	3268	1116	39	1	7593	1	CEP290	12	88535027	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	37963263	88535027	45316868	80	22183											
C12orf12	196477	broad.mit.edu	37	chr12	91347586	91347587	+	In_Frame_Ins	INS	-	TTG	TTG																															tcctcatcttcgacctcttcINSctcctcatcttcgacctctt																								rs3832847		TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr12:91347586_91347587insTTG	uc001tbj.2	-	1	1367_1368	c.933_934insCAA	c.(931-936)insCAA	p.311_312insQ		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	311_312	Potential.|Glu-rich.									central_nervous_system(1)|pancreas(1)	2						tcgacctcttcctcctcatctt	0.064													---	---	---								TTG	91347587	TTG	TTG	91347586	7	5	124	1	0	1	1	0	0	0	0	0	1682	864	30	0	290	0	C12orf12	12	91347586	In_Frame_Ins	INS	-	TCGA-CR-6474-01A-11D-1870-08	2812559	91347586	42504309	81	22184											
FRY	10129	broad.mit.edu	37	chr13	32653003	32653003	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaacggttacatcaagcctCcggttccacctgcttctggc	7	10	9	15	2	2	0	1	0	1	0	4	0	4	0	4	3	4	4	4	3	3	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr13:32653003C>A	uc001utx.2	+	2	599	c.103C>A	c.(103-105)CCG>ACG	p.P35T	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	35					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CATCAAGCCTCCGGTTCCACC	0.478													41	229					4.32679e-17	4.92686e-17	1	0	A	32653003	A	A	32653003	3	1	124	1	0	0	0	0	1	0	0	0	6097	855	30	2	109	2	FRY	13	32653003	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08		32653003	82516875	82	22185											
MYH6	4624	broad.mit.edu	37	chr14	23874010	23874010	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacgcttggtgttcacagtCttccccgccccggattctcc	5	11	8	17	3	3	0	1	0	2	0	5	1	4	1	5	2	0	2	5	2	0	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr14:23874010C>A	uc001wjv.2	-	7	619	c.552G>T	c.(550-552)AAG>AAT	p.K184N	MYH6_uc010akp.1_Missense_Mutation_p.K184N	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	184	ATP.|Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TGTTCACAGTCTTCCCCGCCC	0.552													7	58					1.06961e-07	1.15076e-07	1	0	A	23874010	A	A	23874010	3	1	124	1	0	0	0	0	1	0	0	0	10091	912	32	2	5399	2	MYH6	14	23874010	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08		23874010	83475530	83	22186											
SIPA1L1	26037	broad.mit.edu	37	chr14	72152344	72152344	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacgggcgcccactagagAggcggtaagtgtgccttcaa	9	7	15	10	3	1	2	1	1	0	1	1	3	1	2	2	3	1	1	2	3	3	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr14:72152344A>T	uc001xms.2	+	10	3718	c.3370A>T	c.(3370-3372)AGG>TGG	p.R1124W	SIPA1L1_uc001xmt.2_Missense_Mutation_p.R1124W|SIPA1L1_uc001xmu.2_Missense_Mutation_p.R1124W|SIPA1L1_uc001xmv.2_Missense_Mutation_p.R1124W|SIPA1L1_uc010ttm.1_Missense_Mutation_p.R599W	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1124					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CCCACTAGAGAGGCGGTAAGT	0.507													7	33					0	0	0	0	T	72152344	T	T	72152344	3	4	124	1	0	0	0	0	1	0	0	0	14394	295	11	5	3404	5	SIPA1L1	14	72152344	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	48278334	72152344	35197196	84	22187											
FMN1	342184	broad.mit.edu	37	chr15	33358886	33358886	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctttaaaagcctccagggcTgtctctggcgactttggctt	6	13	11	11	1	1	0	0	0	1	0	3	1	2	0	2	3	1	3	2	3	2	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:33358886T>A	uc001zhf.3	-	1	1200	c.1200A>T	c.(1198-1200)ACA>ACT	p.T400T	FMN1_uc001zhg.2_Silent_p.T400T	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CCTCCAGGGCTGTCTCTGGCG	0.577													16	58					0	0	0	0	A	33358886	A	A	33358886	2	1	124	1	0	0	0	0	0	0	0	1	5981	1567	55	5		5	FMN1	15	33358886	Silent	SNP	T	TCGA-CR-6474-01A-11D-1870-08		33358886	69172506	85	22188											
C15orf55	256646	broad.mit.edu	37	chr15	34648621	34648621	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgggtcctggagaaaccctAgtacctggggatacggagag	10	7	15	9	1	0	2	0	0	0	2	1	5	1	3	3	5	3	1	3	5	4	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:34648621A>G	uc001zif.2	+	7	2483	c.2328A>G	c.(2326-2328)CTA>CTG	p.L776L	C15orf55_uc010ucc.1_Silent_p.L804L|C15orf55_uc010ucd.1_Silent_p.L794L	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	776						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GAGAAACCCTAGTACCTGGGG	0.537			T	BRD3|BRD4	lethal midline carcinoma								15	81					0	0	0	0	G	34648621	G	G	34648621	2	3	124	1	0	0	0	0	0	0	0	1	1809	407	15	5		5	C15orf55	15	34648621	Silent	SNP	A	TCGA-CR-6474-01A-11D-1870-08	1289735	34648621	67882771	86	22189											
THBS1	7057	broad.mit.edu	37	chr15	39884784	39884784	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagctggactctgactcaGaccgcattggagatacctgt	9	11	10	11	1	3	3	2	1	1	2	3	5	3	4	2	2	2	2	2	2	1	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:39884784G>A	uc001zkh.2	+	17	2727	c.2548G>A	c.(2548-2550)GAC>AAC	p.D850N	THBS1_uc010bbi.2_Missense_Mutation_p.D322N	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	850	TSP type-3 6.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CTCTGACTCAGACCGCATTGG	0.448													5	14					0	0	0	0	A	39884784	A	A	39884784	3	1	124	1	0	0	0	0	1	0	0	0	15919	942	33	2	2610	2	THBS1	15	39884784	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	5236163	39884784	62646608	87	22190											
THBS1	7057	broad.mit.edu	37	chr15	39884823	39884823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgacaacaatcaggatattGatgaagatggccaccagaac	16	7	10	8	0	1	5	1	3	0	2	1	6	1	6	2	2	2	0	2	2	5	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:39884823G>A	uc001zkh.2	+	17	2766	c.2587G>A	c.(2587-2589)GAT>AAT	p.D863N	THBS1_uc010bbi.2_Missense_Mutation_p.D335N	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	863	TSP type-3 6.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TCAGGATATTGATGAAGATGG	0.468													7	19					0	0	0	0	A	39884823	A	A	39884823	3	1	124	1	0	0	0	0	1	0	0	0	15919	1290	45	2	2649	2	THBS1	15	39884823	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	39	39884823	62646569	88	22191											
LDHAL6B	92483	broad.mit.edu	37	chr15	59499449	59499449	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcccttgtggatcttgatGaagacaaactgaagggtgag	11	11	13	6	0	1	5	0	4	1	1	1	6	1	6	1	2	2	0	1	2	3	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:59499449G>A	uc002agb.2	+	1	408	c.310G>A	c.(310-312)GAA>AAA	p.E104K	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	104	NAD (By similarity).				glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	GGATCTTGATGAAGACAAACT	0.438													18	122					0	0	0	0	A	59499449	A	A	59499449	3	1	124	1	0	0	0	0	1	0	0	0	8740	1291	45	2	312	2	LDHAL6B	15	59499449	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	19614626	59499449	43031943	89	22192											
MORF4L1	10933	broad.mit.edu	37	chr15	79172896	79172896	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaacaagtgaaatacttcAtacattacagtggttggaat	17	11	7	6	0	1	1	1	1	0	0	1	2	1	2	0	2	4	1	0	2	7	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:79172896A>G	uc002bel.2	+	3	318	c.130A>G	c.(130-132)ATA>GTA	p.I44V	MORF4L1_uc010bli.1_Missense_Mutation_p.I44V|MORF4L1_uc010blj.1_Missense_Mutation_p.I44V|MORF4L1_uc002bem.2_Missense_Mutation_p.I44V|MORF4L1_uc010une.1_5'UTR	NM_206839	NP_996670	Q9UBU8	MO4L1_HUMAN	MORF-related gene 15 isoform 2	44	Interaction with MYST1.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding				0						GAAATACTTCATACATTACAG	0.289													10	30					0	0	0	0	G	79172896	G	G	79172896	3	3	124	1	0	0	0	0	1	0	0	0	9759	217	8	5	140	5	MORF4L1	15	79172896	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	19673447	79172896	23358496	90	22193											
DET1	55070	broad.mit.edu	37	chr15	89074302	89074302	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgacaagaccaccttgTcacacttgaacgtgcgtgta	10	11	10	10	2	1	3	1	2	0	1	1	3	1	3	2	0	2	1	2	0	3	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:89074302T>C	uc002bmr.2	-	2	787	c.635A>G	c.(634-636)GAC>GGC	p.D212G	DET1_uc002bmp.3_RNA|DET1_uc010bnk.2_RNA|DET1_uc002bmq.2_Missense_Mutation_p.D223G	NM_001144074	NP_001137546	Q7L5Y6	DET1_HUMAN	de-etiolated 1 isoform 2	212						nucleus				lung(1)|pancreas(1)	2	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			GACCACCTTGTCACACTTGAA	0.502													13	53					0	0	0	0	C	89074302	C	C	89074302	3	2	124	1	0	0	0	0	1	0	0	0	4472	1667	58	5	1033	5	DET1	15	89074302	Missense_Mutation	SNP	T	TCGA-CR-6474-01A-11D-1870-08	9901406	89074302	13457090	91	22194											
KIAA0430	9665	broad.mit.edu	37	chr16	15694394	15694394	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgattggcaggggagagactGagtgaactcaaacgacctac	13	7	13	8	1	1	4	1	3	0	1	1	7	1	5	1	3	3	1	1	3	3	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr16:15694394G>C	uc002ddr.2	-	25	4897	c.4704C>G	c.(4702-4704)CTC>CTG	p.L1568L	KIAA0430_uc002ddq.2_Silent_p.L1402L|KIAA0430_uc010uzv.1_Silent_p.L1564L|KIAA0430_uc010uzw.1_Silent_p.L1567L	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	1567						peroxisome	nucleotide binding|RNA binding				0						GGGAGAGACTGAGTGAACTCA	0.552													22	74					0	0	0	0	C	15694394	C	C	15694394	2	2	124	1	0	0	0	0	0	0	0	1	8216	1277	45	2		2	KIAA0430	16	15694394	Silent	SNP	G	TCGA-CR-6474-01A-11D-1870-08		15694394	74660359	92	22195											
ADAMTS18	170692	broad.mit.edu	37	chr16	77397755	77397755	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacgtttatgtcacttccaaTagtcccatctttaaataggc	11	14	5	11	1	2	0	1	0	1	0	4	0	4	0	2	1	0	1	2	1	6	7			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr16:77397755T>G	uc002ffc.3	-	6	1419	c.1000A>C	c.(1000-1002)ATT>CTT	p.I334L	ADAMTS18_uc010chc.1_5'UTR|ADAMTS18_uc002ffe.1_Missense_Mutation_p.I30L|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	334	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TCACTTCCAATAGTCCCATCT	0.368													8	41					0	0	0	0	G	77397755	G	G	77397755	3	3	124	1	0	0	0	0	1	0	0	0	263	1406	49	5	2737	5	ADAMTS18	16	77397755	Missense_Mutation	SNP	T	TCGA-CR-6474-01A-11D-1870-08	61703361	77397755	12956998	93	22196											
RNMTL1	55178	broad.mit.edu	37	chr17	691248	691248	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttaagatgacatatccaaaGactcagcttcagcattcact	14	11	6	10	0	3	3	3	1	0	2	4	3	4	3	1	0	2	3	1	0	3	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:691248G>A	uc002frw.2	+	3	709	c.603G>A	c.(601-603)AAG>AAA	p.K201K		NM_018146	NP_060616	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	201					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		CATATCCAAAGACTCAGCTTC	0.483													14	187					0	0	0	0	A	691248	A	A	691248	2	1	124	1	0	0	0	0	0	0	0	1	13572	933	33	2		2	RNMTL1	17	691248	Silent	SNP	G	TCGA-CR-6474-01A-11D-1870-08		691248	80503962	94	22197											
MNT	4335	broad.mit.edu	37	chr17	2298243	2298243	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagggtccccagcgtgggTgggggcggctgctggggggc	2	7	22	10	2	1	0	1	0	0	0	2	0	2	0	2	8	2	2	2	8	0	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:2298243T>G	uc002fur.2	-	2	831	c.579A>C	c.(577-579)CCA>CCC	p.P193P		NM_020310	NP_064706	Q99583	MNT_HUMAN	MAX binding protein	193					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			skin(1)	1				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		CCAGCGTGGGTGGGGGCGGCT	0.672													4	13					0	0	0	0	G	2298243	G	G	2298243	2	3	124	1	0	0	0	0	0	0	0	1	9731	1683	59	5		5	MNT	17	2298243	Silent	SNP	T	TCGA-CR-6474-01A-11D-1870-08	1606995	2298243	78896967	95	22198											
NEURL4	84461	broad.mit.edu	37	chr17	7230951	7230951	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcctgtggcagccacacCgcaatcccgcccattcaccc	8	5	8	20	2	1	0	1	0	0	0	2	0	2	0	6	2	1	2	6	2	1	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:7230951C>A	uc002gga.1	-	2	542	c.535G>T	c.(535-537)GGT>TGT	p.G179C	NEURL4_uc002ggb.1_Missense_Mutation_p.G179C|NEURL4_uc002ggc.1_5'Flank	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	179	NHR 1.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCAGCCACACCGCAATCCCGC	0.652													32	43					2.20262e-25	2.56424e-25	1	0	A	7230951	A	A	7230951	3	1	124	1	0	0	0	0	1	0	0	0	10401	652	23	3	4265	3	NEURL4	17	7230951	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	4932708	7230951	73964259	96	22199											
TP53	7157	broad.mit.edu	37	chr17	7577547	7577547	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggatgggcctccggttcatgCcgcccatgcaggaactgtta	7	9	13	12	2	1	0	1	0	0	0	2	2	2	2	4	4	3	3	4	4	2	2	rs121912656		TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:7577547C>A	uc002gim.2	-	7	928	c.734G>T	c.(733-735)GGC>GTC	p.G245V	TP53_uc002gig.1_Missense_Mutation_p.G245V|TP53_uc002gih.2_Missense_Mutation_p.G245V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113V|TP53_uc010cng.1_Missense_Mutation_p.G113V|TP53_uc002gii.1_Missense_Mutation_p.G113V|TP53_uc010cnh.1_Missense_Mutation_p.G245V|TP53_uc010cni.1_Missense_Mutation_p.G245V|TP53_uc002gij.2_Missense_Mutation_p.G245V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152V|TP53_uc002gio.2_Missense_Mutation_p.G113V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245del(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.S241_G245delSCMGG(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			40	42					1.62957e-23	1.88306e-23	1	0	A	7577547	A	A	7577547	3	1	124	1	0	0	0	0	1	0	0	0	16448	739	26	4	556	4	TP53	17	7577547	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	346596	7577547	73617663	97	22200											
WRAP53	55135	broad.mit.edu	37	chr17	7592167	7592167	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcagctgtgtcccaggagctAcgggagggggacccagtttc	7	8	15	11	1	1	0	1	0	0	0	3	3	2	3	2	4	3	3	2	4	1	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:7592167A>G	uc010vuh.1	+	2	356	c.201A>G	c.(199-201)CTA>CTG	p.L67L	WRAP53_uc010vui.1_Silent_p.L67L|WRAP53_uc002gip.2_Silent_p.L67L|WRAP53_uc002gir.2_Silent_p.L67L|WRAP53_uc002giq.2_RNA|WRAP53_uc010cnl.2_Silent_p.L67L|TP53_uc010cnh.1_5'Flank|TP53_uc010cni.1_5'Flank|TP53_uc002gim.2_5'Flank|TP53_uc002gij.2_5'Flank|TP53_uc002gin.2_5'Flank|TP53_uc002gio.2_5'Flank|TP53_uc010vug.1_5'Flank|TP53_uc010cnk.1_5'Flank	NM_001143990	NP_001137462	Q9BUR4	WAP53_HUMAN	WD repeat domain 79 isoform 2	67					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding				0						CCCAGGAGCTACGGGAGGGGG	0.577													29	90					0	0	0	0	G	7592167	G	G	7592167	2	3	124	1	0	0	0	0	0	0	0	1	17468	378	14	5		5	WRAP53	17	7592167	Silent	SNP	A	TCGA-CR-6474-01A-11D-1870-08	14620	7592167	73603043	98	22201											
PER1	5187	broad.mit.edu	37	chr17	8047060	8047060	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtggggtgggccagggggTggagggtggcacgggtgagg	4	6	27	4	1	0	1	0	1	0	0	0	2	0	2	1	11	0	1	1	11	0	0			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:8047060T>G	uc002gkd.2	-	19	2834	c.2596A>C	c.(2596-2598)ACC>CCC	p.T866P	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_Intron	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	866	Pro-rich.				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						GGCCAGGGGGTGGAGGGTGGC	0.667			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					4	24					0	0	0	0	G	8047060	G	G	8047060	3	3	124	1	0	0	0	0	1	0	0	0	11783	1696	59	5	1296	5	PER1	17	8047060	Missense_Mutation	SNP	T	TCGA-CR-6474-01A-11D-1870-08	454893	8047060	73148150	99	22202											
MYH8	4626	broad.mit.edu	37	chr17	10293886	10293886	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagctcatgctggagtttgCggaatttagatagattagca	11	12	11	7	1	1	2	1	0	0	2	1	4	1	4	1	2	4	4	1	2	4	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:10293886C>G	uc002gmm.2	-	40	5794	c.5699G>C	c.(5698-5700)CGC>CCC	p.R1900P	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1900	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CTGGAGTTTGCGGAATTTAGA	0.453									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				19	143					0	0	0	0	G	10293886	G	G	10293886	3	3	124	1	0	0	0	0	1	0	0	0	10094	768	27	3	118	3	MYH8	17	10293886	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	2246826	10293886	70901324	100	22203											
FLII	2314	broad.mit.edu	37	chr17	18156743	18156743	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggaattcaggtacagcttCttcagcttgctcagcttgca	8	14	9	10	0	4	0	3	0	1	0	4	1	4	1	0	2	6	6	0	2	2	7			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:18156743C>T	uc002gsr.1	-	9	936	c.885G>A	c.(883-885)AAG>AAA	p.K295K	FLII_uc002gsq.1_Silent_p.K167K|FLII_uc010cpy.1_Silent_p.K284K|FLII_uc010vxn.1_Silent_p.K264K|FLII_uc010vxo.1_Silent_p.K241K|FLII_uc002gss.1_Silent_p.K295K	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	295	Interaction with LRRFIP1 and LRRFIP2.|LRR 13.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					GGTACAGCTTCTTCAGCTTGC	0.587													29	61					0	0	0	0	T	18156743	T	T	18156743	2	4	124	1	0	0	0	0	0	0	0	1	5957	912	32	2		2	FLII	17	18156743	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08	7862857	18156743	63038467	101	22204											
C17orf79	55352	broad.mit.edu	37	chr17	30179963	30179963	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagttctccatcagagtcctCctcatccatggcaaagcctt	9	11	6	15	0	3	1	2	0	1	1	7	1	6	1	5	1	1	2	5	1	1	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:30179963C>G	uc002hgp.2	-	3	361	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	C17orf79_uc010css.2_RNA	NM_018405	NP_060875	Q9NQ92	COPR5_HUMAN	chromosome 17 open reading frame 79	85					histone H4-R3 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding				0		all_cancers(10;4.54e-07)|all_hematologic(16;0.0216)|Acute lymphoblastic leukemia(14;0.0255)|Myeloproliferative disorder(56;0.0393)|Ovarian(249;0.1)				TCAGAGTCCTCCTCATCCATG	0.522													26	243					0	0	0	0	G	30179963	G	G	30179963	3	3	124	1	0	0	0	0	1	0	0	0	1892	864	30	2	309	2	C17orf79	17	30179963	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	12023220	30179963	51015247	102	22205											
CCL15	6359	broad.mit.edu	37	chr17	34325338	34325338	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacacctggcttggagcactCgctgctcgtttcaaaataac	10	10	9	12	2	1	0	1	0	0	0	3	2	1	1	1	2	3	5	1	2	3	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:34325338C>T	uc010wcu.1	-	3	795	c.226G>A	c.(226-228)GAG>AAG	p.E76K	CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA	NM_032965	NP_116741	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15 precursor	76					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTGGAGCACTCGCTGCTCGTT	0.522													3	41					0	0	0	0	T	34325338	T	T	34325338	3	4	124	1	0	0	0	0	1	0	0	0	2899	893	31	1	123	1	CCL15	17	34325338	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	4145375	34325338	46869872	103	22206											
THRA	7067	broad.mit.edu	37	chr17	38240101	38240101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accccagggcttctttcgccGcacaatccagaagaacctcc	10	7	7	17	2	1	2	0	0	1	2	4	2	3	2	6	1	1	2	6	1	3	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:38240101G>A	uc002htw.2	+	5	719	c.236G>A	c.(235-237)CGC>CAC	p.R79H	THRA_uc010cwp.1_Missense_Mutation_p.R79H|THRA_uc002htv.2_Missense_Mutation_p.R79H|THRA_uc002htx.2_Missense_Mutation_p.R79H	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	79	Nuclear receptor.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	TTCTTTCGCCGCACAATCCAG	0.547													4	105					0	0	0	0	A	38240101	A	A	38240101	3	1	124	1	0	0	0	0	1	0	0	0	15939	1087	38	1	250	1	THRA	17	38240101	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	3914763	38240101	42955109	104	22207											
ABCA10	10349	broad.mit.edu	37	chr17	67189687	67189687	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagttttctcttctgcccacCacttaattttttagcaataa	10	18	3	10	0	2	0	0	0	2	0	3	0	2	0	2	0	2	2	2	0	5	9			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:67189687C>A	uc010dfa.1	-	15	2467	c.1588G>T	c.(1588-1590)GGT>TGT	p.G530C	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.G131C	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	530	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TTCTGCCCACCACTTAATTTT	0.299													7	13					0.000274275	0.000287161	1	0	A	67189687	A	A	67189687	3	1	124	1	0	0	0	0	1	0	0	0	29	594	21	4	3147	4	ABCA10	17	67189687	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	28949586	67189687	14005523	105	22208											
MYOM1	8736	broad.mit.edu	37	chr18	3086058	3086059	+	Frame_Shift_Ins	INS	-	T	T																															tgttataagcagggtacataINStaccatccttaaagtcatgc																										TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr18:3086058_3086059insT	uc002klp.2	-	30	4562_4563	c.4228_4229insA	c.(4228-4230)ATAfs	p.I1410fs	MYOM1_uc002klq.2_Frame_Shift_Ins_p.I1314fs	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1410	Ig-like C2-type 4.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CAGGGTACATATACCATCCTTA	0.366													---	---	---								T	3086059	T	T	3086058	7	5	124	1	0	1	1	0	0	0	0	0	10144	449	16	0	864	0	MYOM1	18	3086058	Frame_Shift_Ins	INS	-	TCGA-CR-6474-01A-11D-1870-08		3086058	74991190	106	22209											
SETBP1	26040	broad.mit.edu	37	chr18	42530201	42530201	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaagcagccacagctcacCagccccacccagcagctctg	10	3	7	21	0	2	0	1	0	1	0	2	0	2	0	6	0	6	4	6	0	1	0			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr18:42530201C>G	uc010dni.2	+	4	1192	c.896C>G	c.(895-897)CCA>CGA	p.P299R		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	299						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CACAGCTCACCAGCCCCACCC	0.572									Schinzel-Giedion_syndrome				12	59					0	0	0	0	G	42530201	G	G	42530201	3	3	124	1	0	0	0	0	1	0	0	0	14194	594	21	4	1099	4	SETBP1	18	42530201	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	39444143	42530201	35547047	107	22210											
MATK	4145	broad.mit.edu	37	chr19	3779783	3779783	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccttttgccccaggtactcaCcctgcaggacagctgggggg	6	8	13	14	0	1	0	1	0	0	0	1	1	1	1	4	5	4	3	4	5	1	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:3779783C>T	uc002lyt.2	-	9	1155	c.755G>A	c.(754-756)GGT>GAT	p.G252D	MATK_uc002lyv.2_Missense_Mutation_p.G253D|MATK_uc002lyu.2_Missense_Mutation_p.G211D|MATK_uc010dtq.2_Missense_Mutation_p.G252D	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	252	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGTACTCACCCTGCAGGAC	0.627													8	64					0	0	0	0	T	3779783	T	T	3779783	3	4	124	1	0	0	0	0	1	0	0	0	9385	507	18	4	792	4	MATK	19	3779783	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08		3779783	55349200	108	22211											
MAP2K2	5605	broad.mit.edu	37	chr19	4110577	4110577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaagcccacgatgtacggcGagttgcattcgtgcaggacc	10	7	13	11	4	0	1	0	0	0	1	1	4	0	2	2	2	4	4	2	2	2	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:4110577G>A	uc002lzk.2	-	3	634	c.380C>T	c.(379-381)TCG>TTG	p.S127L		NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	127	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GATGTACGGCGAGTTGCATTC	0.612									Cardiofaciocutaneous_syndrome				8	48					0	0	0	0	A	4110577	A	A	4110577	3	1	124	1	0	0	0	0	1	0	0	0	9290	1059	37	1	858	1	MAP2K2	19	4110577	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	330794	4110577	55018406	109	22212											
ZNF441	126068	broad.mit.edu	37	chr19	11888528	11888528	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagagatgtgatgcaggaaAccatcagaaacctggactgt	15	7	11	8	0	1	3	1	1	0	2	1	6	1	5	2	2	3	1	2	2	2	0			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:11888528A>G	uc010dyj.2	+	2	300	c.106A>G	c.(106-108)ACC>GCC	p.T36A	ZNF441_uc002msn.3_5'UTR	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	36	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GATGCAGGAAACCATCAGAAA	0.423													10	45					0	0	0	0	G	11888528	G	G	11888528	3	3	124	1	0	0	0	0	1	0	0	0	17981	43	2	5	112	5	ZNF441	19	11888528	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	7777951	11888528	47240455	110	22213											
ABHD8	79575	broad.mit.edu	37	chr19	17411962	17411962	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtcaatatggatggtcctcTtggggcgcctggctcgccgc	5	10	14	12	3	2	0	1	0	1	0	4	1	3	1	3	5	0	1	3	5	2	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:17411962T>C	uc002ngb.3	-	2	704	c.464A>G	c.(463-465)AAG>AGG	p.K155R		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	155							hydrolase activity				0						GATGGTCCTCTTGGGGCGCCT	0.473													13	45					0	0	0	0	C	17411962	C	C	17411962	3	2	124	1	0	0	0	0	1	0	0	0	87	1609	56	5	871	5	ABHD8	19	17411962	Missense_Mutation	SNP	T	TCGA-CR-6474-01A-11D-1870-08	5523434	17411962	41717021	111	22214											
ZNF493	284443	broad.mit.edu	37	chr19	21606158	21606158	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctagacacaggagagttcatActggagagaaatcctacaaa	17	7	9	8	0	1	3	1	0	0	3	2	6	2	4	1	2	2	1	1	2	5	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:21606158A>T	uc002npx.2	+	2	593	c.313A>T	c.(313-315)ACT>TCT	p.T105S	ZNF493_uc002npw.2_Missense_Mutation_p.T233S|ZNF493_uc002npy.2_Missense_Mutation_p.T105S	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAGAGTTCATACTGGAGAGAA	0.368													17	47					0	0	0	0	T	21606158	T	T	21606158	3	4	124	1	0	0	0	0	1	0	0	0	18011	391	14	5	774	5	ZNF493	19	21606158	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	4194196	21606158	37522825	112	22215											
ZNF99	7652	broad.mit.edu	37	chr19	22939994	22939994	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgcttaaaagctttgccAcattcttcacatttgtatgg	10	15	7	9	0	2	0	1	0	1	0	2	1	2	0	1	1	3	3	1	1	3	6			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:22939994A>G	uc010xrh.1	-	6	2337	c.2337T>C	c.(2335-2337)TGT>TGC	p.C779C		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAGCTTTGCCACATTCTTCAC	0.373													8	65					0	0	0	0	G	22939994	G	G	22939994	2	3	124	1	0	0	0	0	0	0	0	1	18271	157	6	5		5	ZNF99	19	22939994	Silent	SNP	A	TCGA-CR-6474-01A-11D-1870-08	1333836	22939994	36188989	113	22216											
CD22	933	broad.mit.edu	37	chr19	35832025	35832025	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctcgtgggcctcccctgtCgccctgaatgtccagtgtga	4	11	12	14	2	0	2	0	2	0	0	4	2	2	2	5	1	1	1	5	1	1	0			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:35832025C>T	uc010edt.2	+	7	1568	c.1491C>T	c.(1489-1491)GTC>GTT	p.V497V	CD22_uc010xst.1_Silent_p.V325V|CD22_uc010edu.2_Silent_p.V409V|CD22_uc010edv.2_Silent_p.V497V|CD22_uc002nzb.3_Silent_p.V320V|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	497	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CCTCCCCTGTCGCCCTGAATG	0.627													36	64					0	0	0	0	T	35832025	T	T	35832025	2	4	124	1	0	0	0	0	0	0	0	1	3000	871	31	1		1	CD22	19	35832025	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08	12892031	35832025	23296958	114	22217											
NLRP8	126205	broad.mit.edu	37	chr19	56473581	56473581	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggccgcactgaggcaccctCagtgcaaactgcaaaagcta	12	5	10	14	2	1	1	1	1	0	0	1	1	1	1	2	2	4	5	2	2	4	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:56473581C>G	uc002qmh.2	+	4	2262	c.2191C>G	c.(2191-2193)CAG>GAG	p.Q731E	NLRP8_uc010etg.2_Missense_Mutation_p.Q731E	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	731						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGGCACCCTCAGTGCAAACT	0.478													17	68					0	0	0	0	G	56473581	G	G	56473581	3	3	124	1	0	0	0	0	1	0	0	0	10537	827	29	2	2205	2	NLRP8	19	56473581	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	20641556	56473581	2655402	115	22218											
ZIM3	114026	broad.mit.edu	37	chr19	57646638	57646638	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagctctcttcccagtgtgaAttttctcatgatcgatgaca	10	14	7	10	1	2	3	1	3	2	0	6	4	3	3	1	0	1	1	1	0	2	3			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:57646638A>C	uc002qnz.1	-	5	1453	c.1067T>G	c.(1066-1068)ATT>AGT	p.I356S		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	356	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCAGTGTGAATTTTCTCATG	0.388													21	133					0	0	0	0	C	57646638	C	C	57646638	3	2	124	1	0	0	0	0	1	0	0	0	17752	101	4	5	355	5	ZIM3	19	57646638	Missense_Mutation	SNP	A	TCGA-CR-6474-01A-11D-1870-08	1173057	57646638	1482345	116	22219											
TMC2	117532	broad.mit.edu	37	chr20	2542577	2542577	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aactggcccagatcctggagCaggtggaagaaaaaaagaag	17	4	13	7	0	0	3	0	0	0	3	1	5	1	5	2	4	2	1	2	4	6	0			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:2542577C>T	uc002wgf.1	+	4	490	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	TMC2_uc002wgg.1_Nonsense_Mutation_p.Q143*|TMC2_uc010zpw.1_5'UTR|TMC2_uc010zpx.1_5'UTR	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	159	Arg/Asp/Glu/Lys-rich (highly charged).|Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GATCCTGGAGCAGGTGGAAGA	0.627													13	70					0	0	0	0	T	2542577	T	T	2542577	4	4	124	1	0	0	0	0	0	1	0	0	16051	711	25	4	489	4	TMC2	20	2542577	Nonsense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08		2542577	60482943	117	22220											
ATRN	8455	broad.mit.edu	37	chr20	3541513	3541513	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatctttggtcactgccctCtctatggatatataagcaat	10	15	6	10	0	4	0	2	0	2	0	5	1	4	1	1	2	2	1	1	2	5	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:3541513C>G	uc002wim.2	+	8	1498	c.1408C>G	c.(1408-1410)CTC>GTC	p.L470V	ATRN_uc002wil.2_Missense_Mutation_p.L470V	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	470	Extracellular (Potential).|Kelch 3.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						TCACTGCCCTCTCTATGGATA	0.418													5	66					0	0	0	0	G	3541513	G	G	3541513	3	3	124	1	0	0	0	0	1	0	0	0	1208	913	32	2	1438	2	ATRN	20	3541513	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	998936	3541513	59484007	118	22221											
PLCB1	23236	broad.mit.edu	37	chr20	8352093	8352093	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgggagacacgccaaagctcCcaaggtaggaggttgagtgt	11	7	15	8	1	0	2	0	1	0	1	1	4	1	3	2	4	1	3	2	4	3	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:8352093C>G	uc002wnb.2	+	3	245	c.242C>G	c.(241-243)CCC>CGC	p.P81R	PLCB1_uc010zrb.1_5'UTR|PLCB1_uc010gbv.1_Missense_Mutation_p.P81R|PLCB1_uc002wmz.1_Missense_Mutation_p.P81R|PLCB1_uc002wna.2_Missense_Mutation_p.P81R	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	81					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GCCAAAGCTCCCAAGGTAGGA	0.458													9	51					0	0	0	0	G	8352093	G	G	8352093	3	3	124	1	0	0	0	0	1	0	0	0	12082	623	22	4	252	4	PLCB1	20	8352093	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	4810580	8352093	54673427	119	22222											
KIF16B	55614	broad.mit.edu	37	chr20	16359581	16359581	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctccatgcccagggtggaGtgcctctgcagcgcagaatg	8	8	13	12	1	2	1	0	0	2	1	3	2	2	2	3	2	4	2	3	2	1	0			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:16359581G>C	uc002wpg.1	-	19	3224	c.3066C>G	c.(3064-3066)CAC>CAG	p.H1022Q	KIF16B_uc002wpe.1_Missense_Mutation_p.H404Q|KIF16B_uc002wpf.1_Missense_Mutation_p.H404Q|KIF16B_uc010gch.1_Missense_Mutation_p.H1022Q|KIF16B_uc010gci.1_Missense_Mutation_p.H1022Q|KIF16B_uc010gcj.1_Missense_Mutation_p.H1033Q	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	1022	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity	p.H1022Q(1)		skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CCAGGGTGGAGTGCCTCTGCA	0.597													6	106					0	0	0	0	C	16359581	C	C	16359581	3	2	124	1	0	0	0	0	1	0	0	0	8317	1020	36	4	919	4	KIF16B	20	16359581	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	8007488	16359581	46665939	120	22223											
RBM39	9584	broad.mit.edu	37	chr20	34317447	34317447	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cactgttaaattttggtccgGagctaaaaaggaaacacaaa	17	9	8	7	1	0	0	0	0	0	0	1	2	1	2	1	3	2	2	1	3	7	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:34317447G>A	uc002xeb.2	-	5	643	c.299C>T	c.(298-300)TCC>TTC	p.S100F	RBM39_uc002xdz.2_Missense_Mutation_p.S76F|RBM39_uc002xea.2_5'UTR|RBM39_uc010gfn.2_5'UTR|RBM39_uc010zvm.1_Intron|RBM39_uc002xeg.2_Intron|RBM39_uc002xec.2_Missense_Mutation_p.S100F|RBM39_uc002xed.2_5'UTR|RBM39_uc002xee.2_5'UTR|RBM39_uc002xef.2_5'UTR|RBM39_uc010zvn.1_5'UTR	NM_184234	NP_909122	Q14498	RBM39_HUMAN	RNA binding motif protein 39 isoform a	100					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					TTTTGGTCCGGAGCTAAAAAG	0.373													4	53					0	0	0	0	A	34317447	A	A	34317447	3	1	124	1	0	0	0	0	1	0	0	0	13198	1174	41	2	1345	2	RBM39	20	34317447	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08	17957866	34317447	28708073	121	22224											
ADAMTS1	9510	broad.mit.edu	37	chr21	28216933	28216933	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaggtcggtttccggaagcGgcgtctcggacccggatttg	5	9	15	12	6	1	0	0	0	1	0	4	3	2	3	3	6	1	1	3	6	1	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr21:28216933G>A	uc002ymf.2	-	1	796	c.341C>T	c.(340-342)CCG>CTG	p.P114L		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	114					integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		TTCCGGAAGCGGCGTCTCGGA	0.677											OREG0026151	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	16					0	0	0	0	A	28216933	A	A	28216933	3	1	124	1	0	0	0	0	1	0	0	0	255	1116	39	1	2598	1	ADAMTS1	21	28216933	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08		28216933	19912962	122	22225											
KRTAP10-11	386678	broad.mit.edu	37	chr21	46066855	46066855	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgtgctgtgtgtccacCtgctctgaggattcctcttc	3	15	10	13	0	2	1	0	1	2	0	5	2	4	2	4	1	2	2	4	1	0	2			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr21:46066855C>T	uc002zfr.3	+	1	525	c.480C>T	c.(478-480)ACC>ACT	p.T160T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	160	25 X 5 AA repeats of C-C-X(3).|15.					keratin filament				ovary(1)	1						GTGTGTCCACCTGCTCTGAGG	0.383													86	157					0	0	0	0	T	46066855	T	T	46066855	2	4	124	1	0	0	0	0	0	0	0	1	8546	668	24	4		4	KRTAP10-11	21	46066855	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08	17849922	46066855	2063040	123	22226											
EFCAB6	64800	broad.mit.edu	37	chr22	43926760	43926760	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atagcttttgaacgtgcgccGcattggcctccagcagtgca	8	10	11	12	3	0	1	0	1	0	0	1	1	1	1	3	1	5	4	3	1	2	4			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr22:43926760G>A	uc003bdy.1	-	31	4533	c.4318C>T	c.(4318-4320)CGG>TGG	p.R1440W	EFCAB6_uc003bdz.1_Missense_Mutation_p.R1288W|EFCAB6_uc010gzi.1_Missense_Mutation_p.R1288W	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1440	Interaction with AR.|EF-hand 16.|Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				AACGTGCGCCGCATTGGCCTC	0.562													4	108					0	0	0	0	A	43926760	A	A	43926760	3	1	124	1	0	0	0	0	1	0	0	0	4961	1086	38	1	195	1	EFCAB6	22	43926760	Missense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08		43926760	7377806	124	22227											
SAPS2	9701	broad.mit.edu	37	chr22	50862016	50862016	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcatcaaccaggagctctgCcggctcaacacgatggactt	11	7	10	13	2	3	0	2	0	1	0	3	3	3	2	2	3	5	3	2	3	2	1			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr22:50862016C>T	uc003blb.1	+	11	1520	c.1098C>T	c.(1096-1098)TGC>TGT	p.C366C	SAPS2_uc003bky.1_Silent_p.C366C|SAPS2_uc003bkz.1_Silent_p.C366C|SAPS2_uc003blc.2_Silent_p.C366C|SAPS2_uc003bla.1_Silent_p.C367C|uc011arw.1_5'Flank	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	366						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		AGGAGCTCTGCCGGCTCAACA	0.627													6	49					0	0	0	0	T	50862016	T	T	50862016	2	4	124	1	0	0	0	0	0	0	0	1	13902	747	26	4		4	SAPS2	22	50862016	Silent	SNP	C	TCGA-CR-6474-01A-11D-1870-08	6935256	50862016	442550	125	22228											
RPS6KA6	27330	broad.mit.edu	37	chrX	83357104	83357104	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagaagtccattttctcctcGaagttgttttgcaaacccaa	11	13	7	10	1	1	1	0	0	1	1	4	3	2	1	3	0	2	3	3	0	4	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chrX:83357104G>A	uc004eej.1	-	18	1794	c.1717C>T	c.(1717-1719)CGA>TGA	p.R573*	RPS6KA6_uc011mqt.1_Nonsense_Mutation_p.R573*|RPS6KA6_uc011mqu.1_Nonsense_Mutation_p.R470*	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	573	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TTTTCTCCTCGAAGTTGTTTT	0.368													15	7					0	0	0	0	A	83357104	A	A	83357104	4	1	124	1	0	0	0	0	0	1	0	0	13720	1066	37	1	540	1	RPS6KA6	23	83357104	Nonsense_Mutation	SNP	G	TCGA-CR-6474-01A-11D-1870-08		83357104	71913456	126	22229											
KLHL4	56062	broad.mit.edu	37	chrX	86890582	86890582	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattatatgctattggtggaCgtgatggaagttcctgcctc	8	14	12	7	1	0	1	0	1	0	0	2	4	1	3	2	3	2	2	2	3	4	5			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chrX:86890582C>T	uc004efb.2	+	9	1914	c.1732C>T	c.(1732-1734)CGT>TGT	p.R578C	KLHL4_uc004efa.2_Missense_Mutation_p.R578C	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	578	Kelch 4.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TATTGGTGGACGTGATGGAAG	0.398													11	12					0	0	0	0	T	86890582	T	T	86890582	3	4	124	1	0	0	0	0	1	0	0	0	8430	536	19	1	1766	1	KLHL4	23	86890582	Missense_Mutation	SNP	C	TCGA-CR-6474-01A-11D-1870-08	3533478	86890582	68379978	127	22230											
SAMD11	148398	broad.mit.edu	37	chr1	861349	861349	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggggatcctgcaggtgcatCctccgatctgcgactgcccg	6	8	13	14	3	1	0	0	0	1	0	4	3	4	1	4	3	4	2	4	3	0	0			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:861349C>A	uc001abw.1	+	2	108	c.28C>A	c.(28-30)CCT>ACT	p.P10T	SAMD11_uc001abv.1_Missense_Mutation_p.P10T	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	10						nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		GCAGGTGCATCCTCCGATCTG	0.647													7	73					0.000274275	0.000283733	1	0	A	861349	A	A	861349	3	1	125	1	0	0	0	0	1	0	0	0	13881	855	30	2	30	2	SAMD11	1	861349	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08		861349	248389272	1	22231											
TNFRSF4	7293	broad.mit.edu	37	chr1	1149108	1149108	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtcgttgtagaagcccggcCcgcacggacggcacaccgtg	7	5	14	15	7	0	1	0	0	0	1	1	2	0	2	3	3	1	4	3	3	2	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:1149108C>T	uc001ade.2	-	2	208	c.203G>A	c.(202-204)GGG>GAG	p.G68E	TNFRSF4_uc001adf.2_5'UTR	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	68	TNFR-Cys 2.|Extracellular (Potential).				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GAAGCCCGGCCCGCACGGACG	0.692													3	7					0	0	0	0	T	1149108	T	T	1149108	3	4	125	1	0	0	0	0	1	0	0	0	16363	623	22	4	654	4	TNFRSF4	1	1149108	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	287759	1149108	248101513	2	22232											
PRAMEF17	391004	broad.mit.edu	37	chr1	13716862	13716862	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatttctggactatatggTctggagccagggccctctcc	7	11	12	11	0	3	0	0	0	3	0	4	3	3	3	3	5	1	0	3	5	3	3			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:13716862T>G	uc009vnz.1	+	2	379	c.349T>G	c.(349-351)TCT>GCT	p.S117A		NM_001099851	NP_001093321	Q5VTA0	PRA17_HUMAN	PRAME family member 17	117											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;9.86e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|COAD - Colon adenocarcinoma(227;0.000502)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GACTATATGGTCTGGAGCCAG	0.527													21	123					0	0	0	0	G	13716862	G	G	13716862	3	3	125	1	0	0	0	0	1	0	0	0	12492	1667	58	5	355	5	PRAMEF17	1	13716862	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08	12567754	13716862	235533759	3	22233											
HTR6	3362	broad.mit.edu	37	chr1	19992722	19992722	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcgccgctctcgcctcctTcctgcccctgctgctgggct	0	11	9	21	3	1	0	0	0	1	0	5	0	3	0	7	1	3	4	7	1	0	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:19992722T>C	uc001bcl.2	+	1	943	c.476T>C	c.(475-477)TTC>TCC	p.F159S		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	159	Helical; Name=4; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CTCGCCTCCTTCCTGCCCCTG	0.716													6	39					0	0	0	0	C	19992722	C	C	19992722	3	2	125	1	0	0	0	0	1	0	0	0	7490	1783	62	5	478	5	HTR6	1	19992722	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08	6275860	19992722	229257899	4	22234											
C1orf172	126695	broad.mit.edu	37	chr1	27278782	27278783	+	Frame_Shift_Del	DEL	AT	-	-																															gggggctgaggtggtttatcAtatgtctccagacatagctc																										TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:27278782_27278783delAT	uc001bni.1	-	2	178_179	c.89_90delAT	c.(88-90)TATfs	p.Y30fs		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	30	Pro-rich.									large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GTGGTTTATCATATGTCTCCAG	0.629													---	---	---								-	27278783	-	-	27278782	7	5	125	1	0	1	0	1	0	0	0	0	2022	224	8	0	1118	0	C1orf172	1	27278782	Frame_Shift_Del	DEL	AT	TCGA-CR-6477-01A-11D-1870-08	7286060	27278782	221971839	5	22235											
CYP4A11	1579	broad.mit.edu	37	chr1	47407103	47407103	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggctcagcacagagacactCatggtgcagcacctgctgga	10	6	13	12	0	2	1	2	0	0	1	2	3	2	2	1	3	4	5	1	3	0	0			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:47407103C>T	uc001cqp.3	-	1	54	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CYP4A11_uc001cqq.2_Missense_Mutation_p.M1I|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	1					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	CAGAGACACTCATGGTGCAGC	0.597													13	91					0	0	0	0	T	47407103	T	T	47407103	3	4	125	1	0	0	0	0	1	0	0	0	4200	826	29	2	1604	2	CYP4A11	1	47407103	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	20128321	47407103	201843518	6	22236											
C1orf87	127795	broad.mit.edu	37	chr1	60505607	60505607	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accatttcaggagaacccctCttagaaaatctctgacaaag	15	9	6	11	0	3	3	1	1	2	2	4	4	3	3	3	1	1	0	3	1	5	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:60505607C>T	uc001czs.1	-	5	821	c.729G>A	c.(727-729)AAG>AAA	p.K243K		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	243							calcium ion binding			ovary(1)|breast(1)	2						GAGAACCCCTCTTAGAAAATC	0.408													17	327					0	0	0	0	T	60505607	T	T	60505607	2	4	125	1	0	0	0	0	0	0	0	1	2074	912	32	2		2	C1orf87	1	60505607	Silent	SNP	C	TCGA-CR-6477-01A-11D-1870-08	13098504	60505607	188745014	7	22237											
ROR1	4919	broad.mit.edu	37	chr1	64608106	64608106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agatcacaagtgttataacaGcacaggtgtggactaccggg	13	8	12	8	1	1	1	1	0	0	1	1	2	1	2	1	3	3	2	1	3	4	3			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:64608106G>A	uc001dbj.2	+	7	1346	c.947G>A	c.(946-948)AGC>AAC	p.S316N	ROR1_uc001dbi.3_Missense_Mutation_p.S316N|uc001dbl.2_Intron	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	316	Kringle.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						TGTTATAACAGCACAGGTGTG	0.502													3	76					0	0	0	0	A	64608106	A	A	64608106	3	1	125	1	0	0	0	0	1	0	0	0	13591	971	34	4	973	4	ROR1	1	64608106	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	4102499	64608106	184642515	8	22238											
LRRC8B	23507	broad.mit.edu	37	chr1	90048267	90048267	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccagtcatcttatcacatcTtaaaaccatggtgggacgtc	11	11	7	12	1	4	0	2	0	2	0	5	1	4	1	2	2	1	0	2	2	3	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:90048267T>A	uc001dni.2	+	7	565	c.58T>A	c.(58-60)TTA>ATA	p.L20I	LRRC8B_uc001dnh.2_Missense_Mutation_p.L20I|LRRC8B_uc001dnj.2_Missense_Mutation_p.L20I	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	20						integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		TTATCACATCTTAAAACCATG	0.483													13	117					0	0	0	0	A	90048267	A	A	90048267	3	1	125	1	0	0	0	0	1	0	0	0	9072	1606	56	5	60	5	LRRC8B	1	90048267	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08	25440161	90048267	159202354	9	22239											
COL11A1	1301	broad.mit.edu	37	chr1	103496741	103496741	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcacagtctggactataatgCtcacagtagtcatatgctgc	11	12	8	10	0	4	0	3	0	1	0	4	1	4	1	0	1	3	3	0	1	4	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:103496741C>G	uc001dul.2	-	5	1029	c.711G>C	c.(709-711)GAG>GAC	p.E237D	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.E237D|COL11A1_uc001dun.2_Missense_Mutation_p.E237D|COL11A1_uc009weh.2_Missense_Mutation_p.E237D	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	237	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GACTATAATGCTCACAGTAGT	0.458													8	25					0	0	0	0	G	103496741	G	G	103496741	3	3	125	1	0	0	0	0	1	0	0	0	3682	796	28	4	5118	4	COL11A1	1	103496741	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	13448474	103496741	145753880	10	22240											
TRIM46	80128	broad.mit.edu	37	chr1	155148051	155148051	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctcctgcctccacccctTccacccgcagcccccgcctc	3	7	4	27	2	1	0	0	0	1	0	5	0	3	0	11	0	2	1	11	0	0	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:155148051T>C	uc001fhs.1	+	2	336	c.253T>C	c.(253-255)TCC>CCC	p.S85P	RAG1AP1_uc010pey.1_Intron|KRTCAP2_uc001fho.2_5'Flank|KRTCAP2_uc001fhp.1_5'Flank|TRIM46_uc009wpe.1_RNA|TRIM46_uc010pez.1_Missense_Mutation_p.S72P|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Missense_Mutation_p.S85P|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Intron|TRIM46_uc001fhu.1_Missense_Mutation_p.S62P|TRIM46_uc009wpg.1_Missense_Mutation_p.S72P|TRIM46_uc009wpf.2_Missense_Mutation_p.S72P|TRIM46_uc001fhv.3_Missense_Mutation_p.S72P|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	85						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTCCACCCCTTCCACCCGCAG	0.682													4	59					0	0	0	0	C	155148051	C	C	155148051	3	2	125	1	0	0	0	0	1	0	0	0	16588	1783	62	5	259	5	TRIM46	1	155148051	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08	51651310	155148051	94102570	11	22241											
SLC9A11	284525	broad.mit.edu	37	chr1	173503733	173503733	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagatgtattatcataggatAaatatatatcaaatttataa	19	15	4	3	0	2	1	2	0	0	1	2	2	2	2	0	1	0	1	0	1	11	10			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:173503733A>G	uc001giz.2	-	16	2287	c.1864T>C	c.(1864-1866)TAT>CAT	p.Y622H	SLC9A11_uc009wwe.2_Missense_Mutation_p.Y180H|SLC9A11_uc010pmq.1_Intron	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	622	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						ATCATAGGATAAATATATATC	0.259													23	11					0	0	0	0	G	173503733	G	G	173503733	3	3	125	1	0	0	0	0	1	0	0	0	14775	362	13	5	1562	5	SLC9A11	1	173503733	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	18355682	173503733	75746888	12	22242											
ASPM	259266	broad.mit.edu	37	chr1	197070787	197070787	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaataaccacagcagaatGccattgtctgatataatttt	14	13	6	8	0	1	3	0	2	1	1	1	3	1	3	2	0	3	1	2	0	5	6			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:197070787G>A	uc001gtu.2	-	18	7851	c.7594C>T	c.(7594-7596)CAT>TAT	p.H2532Y	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.H380Y	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2532	IQ 27.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ACAGCAGAATGCCATTGTCTG	0.343													14	94					0	0	0	0	A	197070787	A	A	197070787	3	1	125	1	0	0	0	0	1	0	0	0	1058	1319	46	4	2883	4	ASPM	1	197070787	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	23567054	197070787	52179834	13	22243											
NR5A2	2494	broad.mit.edu	37	chr1	200017505	200017505	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cactctgcctccaaaggcctAcctctgaaccatgctgcctt	8	10	6	17	0	2	1	0	1	2	0	3	1	3	1	6	1	5	1	6	1	3	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr1:200017505A>G	uc001gvb.2	+	5	875	c.669A>G	c.(667-669)CTA>CTG	p.L223L	NR5A2_uc001gvc.2_Silent_p.L177L|NR5A2_uc009wzh.2_Silent_p.L183L|NR5A2_uc010pph.1_Silent_p.L151L	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	223					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					CCAAAGGCCTACCTCTGAACC	0.512													19	112					0	0	0	0	G	200017505	G	G	200017505	2	3	125	1	0	0	0	0	0	0	0	1	10690	378	14	5		5	NR5A2	1	200017505	Silent	SNP	A	TCGA-CR-6477-01A-11D-1870-08	2946718	200017505	49233116	14	22244											
SLC1A4	6509	broad.mit.edu	37	chr2	65245373	65245373	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caactcaacaacgtagagctCaacgcaggacagattttcac	15	7	7	12	2	3	2	3	0	0	2	3	3	3	3	0	1	5	3	0	1	5	3			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr2:65245373C>G	uc010yqa.1	+	6	1525	c.1203C>G	c.(1201-1203)CTC>CTG	p.L401L	SLC1A4_uc010ypy.1_Silent_p.L181L|SLC1A4_uc010ypz.1_Silent_p.L103L|SLC1A4_uc010fcv.2_Silent_p.L401L|SLC1A4_uc002sdh.2_Silent_p.L181L	NM_003038	NP_003029	P43007	SATT_HUMAN	solute carrier family 1, member 4 isoform 1	401					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(1)	1					L-Alanine(DB00160)	ACGTAGAGCTCAACGCAGGAC	0.488													7	64					0	0	0	0	G	65245373	G	G	65245373	2	3	125	1	0	0	0	0	0	0	0	1	14499	813	29	2		2	SLC1A4	2	65245373	Silent	SNP	C	TCGA-CR-6477-01A-11D-1870-08		65245373	177954000	15	22245											
ST6GAL2	84620	broad.mit.edu	37	chr2	107459945	107459945	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggacctgtgcagccggAaaagccccctcccgtgggcc	6	6	12	17	2	1	0	0	0	1	0	2	2	2	2	6	3	3	1	6	3	2	0			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr2:107459945A>C	uc002tdq.2	-	2	608	c.489T>G	c.(487-489)TTT>TTG	p.F163L	ST6GAL2_uc002tdr.2_Missense_Mutation_p.F163L|ST6GAL2_uc002tds.3_Missense_Mutation_p.F163L	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	163	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GTGCAGCCGGAAAAGCCCCCT	0.642													19	174					0	0	0	0	C	107459945	C	C	107459945	3	2	125	1	0	0	0	0	1	0	0	0	15288	243	9	5	1207	5	ST6GAL2	2	107459945	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	42214572	107459945	135739428	16	22246											
LCT	3938	broad.mit.edu	37	chr2	136566025	136566025	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacacacctttcaaagcctCattgatgtaggttttgtggt	9	15	8	9	0	3	1	3	1	0	0	3	1	3	1	2	2	1	2	2	2	2	5			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr2:136566025C>G	uc002tuu.1	-	8	3903	c.3892G>C	c.(3892-3894)GAG>CAG	p.E1298Q		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1298	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TTCAAAGCCTCATTGATGTAG	0.443													25	230					0	0	0	0	G	136566025	G	G	136566025	3	3	125	1	0	0	0	0	1	0	0	0	8733	835	29	2	1931	2	LCT	2	136566025	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	29106080	136566025	106633348	17	22247											
ACVR1	90	broad.mit.edu	37	chr2	158636996	158636996	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctggtagacgtggaagcCatcgttgatgctcagtgagg	8	12	14	7	2	2	3	1	2	1	1	3	4	2	4	1	3	2	3	1	3	2	3			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr2:158636996C>T	uc002tzm.3	-	5	523	c.184G>A	c.(184-186)GGC>AGC	p.G62S	ACVR1_uc002tzn.3_Missense_Mutation_p.G62S|ACVR1_uc010fog.2_Missense_Mutation_p.G62S	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	62	Extracellular (Potential).				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	ACGTGGAAGCCATCGTTGATG	0.552													19	156					0	0	0	0	T	158636996	T	T	158636996	3	4	125	1	0	0	0	0	1	0	0	0	220	594	21	4	1377	4	ACVR1	2	158636996	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	22070971	158636996	84562377	18	22248											
KCNH7	90134	broad.mit.edu	37	chr2	163302670	163302670	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgatttacatatgttgttCtgaagtttattaaaatatct	12	20	5	4	0	3	2	0	2	3	0	3	2	3	2	0	0	1	3	0	0	7	9			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr2:163302670C>T	uc002uch.1	-	7	1624	c.1412G>A	c.(1411-1413)AGA>AAA	p.R471K	KCNH7_uc002uci.2_Missense_Mutation_p.R464K	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	471	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	ATATGTTGTTCTGAAGTTTAT	0.363													4	38					0	0	0	0	T	163302670	T	T	163302670	3	4	125	1	0	0	0	0	1	0	0	0	8076	913	32	2	2284	2	KCNH7	2	163302670	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	4665674	163302670	79896703	19	22249											
HOXD10	3236	broad.mit.edu	37	chr2	176982013	176982013	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaggttcccgtccctggatAttttagactgagtcagacct	8	13	10	10	1	1	4	1	2	0	2	3	5	3	5	3	2	0	1	3	2	2	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr2:176982013A>G	uc002ukj.2	+	1	522	c.452A>G	c.(451-453)TAT>TGT	p.Y151C		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	151						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GTCCCTGGATATTTTAGACTG	0.552													413	142					0	0	0	0	G	176982013	G	G	176982013	3	3	125	1	0	0	0	0	1	0	0	0	7358	449	16	5	454	5	HOXD10	2	176982013	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	13679343	176982013	66217360	20	22250											
TTN	7273	broad.mit.edu	37	chr2	179586740	179586740	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggacggatctccttgttatcTtttgaccaagtgattcgcat	8	15	9	9	2	2	2	0	2	2	0	4	4	2	4	2	2	0	2	2	2	2	5			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr2:179586740T>C	uc010zfg.1	-	75	19142	c.18918A>G	c.(18916-18918)AAA>AAG	p.K6306K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.K2967K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7233							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTGTTATCTTTTGACCAAG	0.418													23	224					0	0	0	0	C	179586740	C	C	179586740	2	2	125	1	0	0	0	0	0	0	0	1	16803	1606	56	5		5	TTN	2	179586740	Silent	SNP	T	TCGA-CR-6477-01A-11D-1870-08	2604727	179586740	63612633	21	22251											
ANKAR	150709	broad.mit.edu	37	chr2	190592581	190592581	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttcttaaattcatttgaaGatgtgttgaaggctgtatct	10	18	9	4	0	3	3	1	2	2	1	3	3	3	3	0	1	0	4	0	1	5	6			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr2:190592581G>A	uc002uqw.1	+	12	2423	c.2423_splice	c.e12-1	p.D808_splice	ANKAR_uc002uqu.2_Splice_Site|ANKAR_uc002uqx.1_Splice_Site|ANKAR_uc002uqy.1_5'Flank	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing							integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TTCATTTGAAGATGTGTTGAA	0.343													11	45					0	0	0	0	A	190592581	A	A	190592581	5	1	125	1	0	0	0	0	0	0	1	0	623	956	33	2	2681	2	ANKAR	2	190592581	Splice_Site	SNP	G	TCGA-CR-6477-01A-11D-1870-08	11005841	190592581	52606792	22	22252											
CUL3	8452	broad.mit.edu	37	chr2	225376094	225376094	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtctttccatttttcaacAtatgtactagcccagaattc	10	16	4	11	0	2	1	1	0	1	1	4	1	3	1	2	0	3	1	2	0	5	7			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr2:225376094A>C	uc002vny.2	-	6	1244	c.860T>G	c.(859-861)ATG>AGG	p.M287R	CUL3_uc010zls.1_Missense_Mutation_p.M221R|CUL3_uc010fwy.1_Missense_Mutation_p.M293R	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	287					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ATTTTTCAACATATGTACTAG	0.323													21	123					0	0	0	0	C	225376094	C	C	225376094	3	2	125	1	0	0	0	0	1	0	0	0	4073	217	8	5	1490	5	CUL3	2	225376094	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	34783513	225376094	17823279	23	22253											
CNTN6	27255	broad.mit.edu	37	chr3	1320176	1320176	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtgcttctctgtggcccAccgccacattttggaggtat	5	13	12	11	1	1	0	0	0	1	0	2	1	1	1	3	4	1	2	3	4	1	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr3:1320176A>G	uc003boz.2	+	5	705	c.438A>G	c.(436-438)CCA>CCG	p.P146P	CNTN6_uc010hbo.2_Silent_p.P141P|CNTN6_uc011asj.1_Silent_p.P74P|CNTN6_uc003bpa.2_Silent_p.P146P	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	146	Ig-like C2-type 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TCTGTGGCCCACCGCCACATT	0.453													10	74					0	0	0	0	G	1320176	G	G	1320176	2	3	125	1	0	0	0	0	0	0	0	1	3660	146	6	5		5	CNTN6	3	1320176	Silent	SNP	A	TCGA-CR-6477-01A-11D-1870-08		1320176	196702254	24	22254											
SATB1	6304	broad.mit.edu	37	chr3	18391087	18391087	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggttgccgtggggggagccGagggcctgtctgtggctgct	2	9	21	9	2	1	0	0	0	1	0	1	2	1	1	3	6	3	3	3	6	0	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr3:18391087G>A	uc003cbh.2	-	11	3602	c.1867C>T	c.(1867-1869)CGG>TGG	p.R623W	SATB1_uc003cbi.2_Missense_Mutation_p.R655W|SATB1_uc003cbj.2_Missense_Mutation_p.R623W	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	623					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						GGGGGGAGCCGAGGGCCTGTC	0.463													10	38					0	0	0	0	A	18391087	A	A	18391087	3	1	125	1	0	0	0	0	1	0	0	0	13918	1057	37	1	428	1	SATB1	3	18391087	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	17070911	18391087	179631343	25	22255											
LRRC3B	116135	broad.mit.edu	37	chr3	26751571	26751571	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaatgccttcaataacctGaaggccagggccagaattgc	15	7	9	10	0	1	2	1	1	0	1	1	2	1	2	4	2	3	0	4	2	6	3			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr3:26751571G>A	uc003cdp.2	+	2	997	c.408G>A	c.(406-408)CTG>CTA	p.L136L	LRRC3B_uc003cdq.2_Silent_p.L136L	NM_052953	NP_443185	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B precursor	136						integral to membrane				pancreas(2)|ovary(1)|skin(1)	4						TCAATAACCTGAAGGCCAGGG	0.507													23	31					0	0	0	0	A	26751571	A	A	26751571	2	1	125	1	0	0	0	0	0	0	0	1	9046	1277	45	2		2	LRRC3B	3	26751571	Silent	SNP	G	TCGA-CR-6477-01A-11D-1870-08	8360484	26751571	171270859	26	22256											
ZCWPW2	152098	broad.mit.edu	37	chr3	28562601	28562601	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaggaaataaatatgggAgaaaaggtaatattgatagt	19	9	13	0	0	0	3	0	1	0	2	0	6	0	4	0	4	0	1	0	4	9	6			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr3:28562601A>G	uc003ceh.2	+	9	1071	c.903A>G	c.(901-903)GGA>GGG	p.G301G	ZCWPW2_uc003cei.2_Silent_p.G301G|ZCWPW2_uc010hfo.2_Silent_p.G106G	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	301							zinc ion binding			ovary(2)	2						TAAATATGGGAGAAAAGGTAA	0.338													10	20					0	0	0	0	G	28562601	G	G	28562601	2	3	125	1	0	0	0	0	0	0	0	1	17665	291	11	5		5	ZCWPW2	3	28562601	Silent	SNP	A	TCGA-CR-6477-01A-11D-1870-08	1811030	28562601	169459829	27	22257											
SCN10A	6336	broad.mit.edu	37	chr3	38760236	38760236	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagcagcatctcgaacacaaAgataaaggtgaagaccctgt	17	6	9	9	1	1	3	0	1	1	2	2	4	1	3	1	1	3	2	1	1	6	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr3:38760236A>C	uc003ciq.2	-	20	3589	c.3589T>G	c.(3589-3591)TTT>GTT	p.F1197V		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1197	Helical; Name=S2 of repeat III; (Potential).|III.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCGAACACAAAGATAAAGGTG	0.488													7	71					0	0	0	0	C	38760236	C	C	38760236	3	2	125	1	0	0	0	0	1	0	0	0	13977	72	3	5	2313	5	SCN10A	3	38760236	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	10197635	38760236	159262194	28	22258											
CDCP1	64866	broad.mit.edu	37	chr3	45160021	45160021	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatatgtcttttagaaatgaCgatgtaacagggttttgcca	12	15	9	5	1	1	2	0	1	1	1	1	3	1	2	1	1	2	2	1	1	5	7			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr3:45160021C>T	uc003com.2	-	2	310	c.175G>A	c.(175-177)GTC>ATC	p.V59I	CDCP1_uc003con.2_Missense_Mutation_p.V59I	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	59	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TTAGAAATGACGATGTAACAG	0.428													4	94					0	0	0	0	T	45160021	T	T	45160021	3	4	125	1	0	0	0	0	1	0	0	0	3108	536	19	1	2375	1	CDCP1	3	45160021	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	6399785	45160021	152862409	29	22259											
DHX30	22907	broad.mit.edu	37	chr3	47888975	47888975	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agatcaaaggagtgcagcagCgcctccaggaggccctgggc	10	4	15	12	1	1	1	1	0	0	1	2	3	2	3	3	4	3	2	3	4	1	0			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr3:47888975C>T	uc003cru.2	+	13	2485	c.2059C>T	c.(2059-2061)CGC>TGC	p.R687C	DHX30_uc003crt.2_Missense_Mutation_p.R648C|MIR1226_hsa-mir-1226|MI0006313_5'Flank	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	687	Helicase C-terminal.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		AGTGCAGCAGCGCCTCCAGGA	0.632													7	20					0	0	0	0	T	47888975	T	T	47888975	3	4	125	1	0	0	0	0	1	0	0	0	4526	768	27	1	2112	1	DHX30	3	47888975	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	2728954	47888975	150133455	30	22260											
EPHA3	2042	broad.mit.edu	37	chr3	89390112	89390112	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggatggtaatatgaagtgTgctaagtgcccgcctcacag	10	11	12	8	1	1	1	1	1	0	0	1	2	1	2	2	2	2	2	2	2	4	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr3:89390112T>G	uc003dqy.2	+	4	1086	c.861T>G	c.(859-861)TGT>TGG	p.C287W	EPHA3_uc003dqx.1_Missense_Mutation_p.C287W|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	287	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATATGAAGTGTGCTAAGTGCC	0.408										TSP Lung(6;0.00050)			13	127					0	0	0	0	G	89390112	G	G	89390112	3	3	125	1	0	0	0	0	1	0	0	0	5192	1702	59	5	875	5	EPHA3	3	89390112	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08	41501137	89390112	108632318	31	22261											
KIAA1407	57577	broad.mit.edu	37	chr3	113699548	113699548	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcttccaaggctctagaccTtttttccttagcaagaccct	8	14	5	14	0	2	2	0	0	2	2	4	2	4	2	4	1	1	2	4	1	4	6			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr3:113699548T>C	uc003eax.2	-	14	2403	c.2256A>G	c.(2254-2256)AAA>AAG	p.K752K	KIAA1407_uc011bin.1_RNA	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	752										ovary(2)	2						GCTCTAGACCTTTTTTCCTTA	0.408													3	253					0	0	0	0	C	113699548	C	C	113699548	2	2	125	1	0	0	0	0	0	0	0	1	8268	1606	56	5		5	KIAA1407	3	113699548	Silent	SNP	T	TCGA-CR-6477-01A-11D-1870-08	24309436	113699548	84322882	32	22262											
TET2	54790	broad.mit.edu	37	chr4	106158042	106158042	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtcagatgcacaggccaatTaaggtggaacctggatgcaa	14	7	12	8	0	1	1	1	0	0	1	1	3	1	3	2	4	3	2	2	4	4	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr4:106158042T>A	uc003hxk.2	+	3	3329	c.2943T>A	c.(2941-2943)ATT>ATA	p.I981I	TET2_uc011cez.1_Silent_p.I1002I|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Silent_p.I981I|TET2_uc003hxi.1_Silent_p.I981I	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	981					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		ACAGGCCAATTAAGGTGGAAC	0.473			Mis N|F		MDS								18	47					0	0	0	0	A	106158042	A	A	106158042	2	1	125	1	0	0	0	0	0	0	0	1	15836	1742	61	5		5	TET2	4	106158042	Silent	SNP	T	TCGA-CR-6477-01A-11D-1870-08		106158042	84996234	33	22263											
FAT1	2195	broad.mit.edu	37	chr4	187540779	187540779	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgtgattcccaaacatctGgtatgagattcctctatttg	9	15	8	9	0	2	2	0	2	2	1	4	3	4	2	2	1	1	2	2	1	3	5			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr4:187540779G>A	uc003izf.2	-	10	7149	c.6961C>T	c.(6961-6963)CAG>TAG	p.Q2321*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2321	Extracellular (Potential).|Cadherin 21.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CCAAACATCTGGTATGAGATT	0.463										HNSCC(5;0.00058)			37	96					0	0	0	0	A	187540779	A	A	187540779	4	1	125	1	0	0	0	0	0	1	0	0	5721	1357	47	4	6877	4	FAT1	4	187540779	Nonsense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	81382737	187540779	3613497	34	22264											
DNAH5	1767	broad.mit.edu	37	chr5	13721156	13721156	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgagcatggacttcctggcCctggcccatggacacataac	9	7	10	15	1	0	0	0	0	0	0	1	3	1	2	4	4	2	1	4	4	1	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr5:13721156C>A	uc003jfd.2	-	71	12274	c.12232G>T	c.(12232-12234)GGC>TGC	p.G4078C	DNAH5_uc003jfc.2_Missense_Mutation_p.G246C	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4078	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACTTCCTGGCCCTGGCCCATG	0.483									Kartagener_syndrome				17	116					5.01169e-05	5.22959e-05	1	0	A	13721156	A	A	13721156	3	1	125	1	0	0	0	0	1	0	0	0	4626	623	22	4	1678	4	DNAH5	5	13721156	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08		13721156	167194104	35	22265											
MTMR12	54545	broad.mit.edu	37	chr5	32276834	32276834	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctctgttacttccttttcGtttgtgtgaatttcctaaaa	7	21	5	8	1	1	1	0	1	1	0	5	1	3	1	2	0	1	2	2	0	4	8			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr5:32276834G>T	uc003jhq.2	-	2	266	c.96C>A	c.(94-96)AAC>AAA	p.N32K	MTMR12_uc010iuk.2_Missense_Mutation_p.N32K|MTMR12_uc010iul.2_Missense_Mutation_p.N32K	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	32						cytoplasm	phosphatase activity			ovary(1)	1						CTTCCTTTTCGTTTGTGTGAA	0.343													3	53					0.00909568	0.0093289	1	0	T	32276834	T	T	32276834	3	4	125	1	0	0	0	0	1	0	0	0	9994	1136	40	3	2207	3	MTMR12	5	32276834	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	18555678	32276834	148638426	36	22266											
MRPS30	10884	broad.mit.edu	37	chr5	44815046	44815046	+	Frame_Shift_Del	DEL	T	-	-																															gaagcagatgttactcgaccTtttgtctcccaggctgtgat																										TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr5:44815046delT	uc003joh.2	+	5	1100	c.1062delT	c.(1060-1062)CCTfs	p.P354fs		NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	354					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					TTACTCGACCTTTTGTCTCCC	0.373													---	---	---								-	44815046	-	-	44815046	7	5	125	1	0	1	0	1	0	0	0	0	9893	1596	56	0	1080	0	MRPS30	5	44815046	Frame_Shift_Del	DEL	T	TCGA-CR-6477-01A-11D-1870-08	12538212	44815046	136100214	37	22267											
F2RL2	2151	broad.mit.edu	37	chr5	75914422	75914422	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagctccacgaaaggtcttaAtgggtaaggttggctttgcc	9	11	13	8	1	1	0	0	0	1	0	2	2	2	0	2	4	2	4	2	4	3	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr5:75914422A>G	uc003kem.2	-	2	295	c.110T>C	c.(109-111)ATT>ACT	p.I37T	IQGAP2_uc003kek.2_Intron|IQGAP2_uc010izv.2_Intron|IQGAP2_uc011csv.1_Intron|IQGAP2_uc003kel.2_Intron|F2RL2_uc011csw.1_Missense_Mutation_p.I15T	NM_004101	NP_004092	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	37					platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity			skin(2)|ovary(1)	3		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		AAAGGTCTTAATGGGTAAGGT	0.393													3	118					0	0	0	0	G	75914422	G	G	75914422	3	3	125	1	0	0	0	0	1	0	0	0	5370	101	4	5	1018	5	F2RL2	5	75914422	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	31099376	75914422	105000838	38	22268											
GPR98	84059	broad.mit.edu	37	chr5	89941887	89941887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgaggattagaagaaatGatgaccccatttattttgca	13	13	8	7	0	1	5	0	3	1	2	1	6	1	6	2	1	1	1	2	1	4	5			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr5:89941887G>A	uc003kju.2	+	16	3097	c.3001G>A	c.(3001-3003)GAT>AAT	p.D1001N	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1001	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAGAAGAAATGATGACCCCAT	0.308													5	7					0	0	0	0	A	89941887	A	A	89941887	3	1	125	1	0	0	0	0	1	0	0	0	6760	1290	45	2	3063	2	GPR98	5	89941887	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	14027465	89941887	90973373	39	22269											
FAT2	2196	broad.mit.edu	37	chr5	150925423	150925423	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgactttaagaacataggAgcattgtcattttcatcaat	13	15	7	6	0	3	2	3	1	0	1	3	3	3	3	0	1	2	2	0	1	4	7			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr5:150925423A>G	uc003lue.3	-	9	5278	c.5265T>C	c.(5263-5265)GCT>GCC	p.A1755A	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1755	Cadherin 15.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGAACATAGGAGCATTGTCAT	0.403													24	113					0	0	0	0	G	150925423	G	G	150925423	2	3	125	1	0	0	0	0	0	0	0	1	5722	291	11	5		5	FAT2	5	150925423	Silent	SNP	A	TCGA-CR-6477-01A-11D-1870-08	60983536	150925423	29989837	40	22270											
ITPR3	3710	broad.mit.edu	37	chr6	33636910	33636910	+	Frame_Shift_Del	DEL	C	-	-																															cgggccggcaacgcccacgaCgagaatgtgctcagctacta																								rs138892441		TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr6:33636910delC	uc011drk.1	+	18	2385	c.2166delC	c.(2164-2166)GACfs	p.D722fs		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	722	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						ACGCCCACGACGAGAATGTGC	0.607													---	---	---								-	33636910	-	-	33636910	7	5	125	1	0	1	0	1	0	0	0	0	7961	535	19	0	2236	0	ITPR3	6	33636910	Frame_Shift_Del	DEL	C	TCGA-CR-6477-01A-11D-1870-08		33636910	137478157	41	22271											
MAPK14	1432	broad.mit.edu	37	chr6	36070426	36070426	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttattggtgccaatcccctgGgtaagttgaccatatatcct	9	14	8	10	0	0	1	0	1	0	0	2	1	2	1	5	2	1	2	5	2	5	6			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr6:36070426G>T	uc003olp.2	+	10	1322	c.841G>T	c.(841-843)GCT>TCT	p.A281S	MAPK14_uc003olo.2_Missense_Mutation_p.G281C|MAPK14_uc003olq.2_Missense_Mutation_p.A281S|MAPK14_uc003olr.2_Intron|MAPK14_uc011dti.1_Missense_Mutation_p.A204S	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1	281	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						CAATCCCCTGGGTAAGTTGAC	0.373													23	75					3.6726e-16	4.08067e-16	1	0	T	36070426	T	T	36070426	3	4	125	1	0	0	0	0	1	0	0	0	9329	1246	43	4	963	4	MAPK14	6	36070426	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	2433516	36070426	135044641	42	22272											
DST	667	broad.mit.edu	37	chr6	56494141	56494141	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatcaaggtcccgttctttaTacgttttaaacatttcatca	12	16	4	9	2	4	0	3	0	1	0	5	0	5	0	1	1	2	2	1	1	6	7			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr6:56494141T>C	uc003pdf.2	-	31	4311	c.4283A>G	c.(4282-4284)TAT>TGT	p.Y1428C	DST_uc003pcz.3_Missense_Mutation_p.Y1250C|DST_uc011dxj.1_Missense_Mutation_p.Y1279C|DST_uc011dxk.1_Missense_Mutation_p.Y1290C|DST_uc003pcy.3_Missense_Mutation_p.Y924C|DST_uc003pdb.2_Missense_Mutation_p.Y924C|DST_uc003pdc.3_Missense_Mutation_p.Y924C|DST_uc003pdd.3_Missense_Mutation_p.Y924C	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1250					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CCGTTCTTTATACGTTTTAAA	0.383													31	67					0	0	0	0	C	56494141	C	C	56494141	3	2	125	1	0	0	0	0	1	0	0	0	4805	1406	49	5	17652	5	DST	6	56494141	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08	20423715	56494141	114620926	43	22273											
SYNE1	23345	broad.mit.edu	37	chr6	152831446	152831446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagctaactatgctgtccaCggaggatgcgctgctggaca	10	8	13	10	2	0	1	0	0	0	1	1	4	1	4	1	3	5	4	1	3	2	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr6:152831446C>T	uc010kiw.2	-	8	1065	c.463G>A	c.(463-465)GTG>ATG	p.V155M	SYNE1_uc003qot.3_Missense_Mutation_p.V162M|SYNE1_uc003qou.3_Missense_Mutation_p.V155M|SYNE1_uc010kjb.1_Missense_Mutation_p.V155M|SYNE1_uc003qpa.1_Missense_Mutation_p.V155M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	155	Actin-binding.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGCTGTCCACGGAGGATGCG	0.473										HNSCC(10;0.0054)			4	67					0	0	0	0	T	152831446	T	T	152831446	3	4	125	1	0	0	0	0	1	0	0	0	15511	536	19	1	26559	1	SYNE1	6	152831446	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	96337305	152831446	18283621	44	22274											
CNKSR3	154043	broad.mit.edu	37	chr6	154763230	154763230	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctccaacttaccggtccagCcacgccagcagggccttggc	7	7	10	17	2	1	0	0	0	1	0	3	0	2	0	6	3	4	1	6	3	2	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr6:154763230C>T	uc003qpy.2	-	3	916	c.411G>A	c.(409-411)TGG>TGA	p.W137*		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	137	CRIC.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		ACCGGTCCAGCCACGCCAGCA	0.562													3	40					0	0	0	0	T	154763230	T	T	154763230	4	4	125	1	0	0	0	0	0	1	0	0	3623	740	26	4	1300	4	CNKSR3	6	154763230	Nonsense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	1931784	154763230	16351837	45	22275											
CCDC146	57639	broad.mit.edu	37	chr7	76909918	76909918	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacaatgatcgaagaggagAtggtgcagcttcgcaaaaga	15	7	12	7	2	1	4	1	1	0	3	3	6	1	4	0	2	2	3	0	2	4	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr7:76909918A>G	uc003uga.2	+	14	1994	c.1867A>G	c.(1867-1869)ATG>GTG	p.M623V	CCDC146_uc010ldp.2_Missense_Mutation_p.M337V|CCDC146_uc003ugc.2_5'Flank	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	623	Potential.									ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				CGAAGAGGAGATGGTGCAGCT	0.408													5	13					0	0	0	0	G	76909918	G	G	76909918	3	3	125	1	0	0	0	0	1	0	0	0	2792	333	12	5	1917	5	CCDC146	7	76909918	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08		76909918	82228745	46	22276											
MUC17	140453	broad.mit.edu	37	chr7	100683015	100683015	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaggctagcaccgtttcaaCaactgctgttgacaccagca	11	9	9	12	1	1	2	1	2	0	0	1	2	1	2	2	1	5	6	2	1	3	3			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr7:100683015C>T	uc003uxp.1	+	3	8371	c.8318C>T	c.(8317-8319)ACA>ATA	p.T2773I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2773	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|45.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACCGTTTCAACAACTGCTGTT	0.488													63	368					0	0	0	0	T	100683015	T	T	100683015	3	4	125	1	0	0	0	0	1	0	0	0	10027	478	17	4	8328	4	MUC17	7	100683015	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	23773097	100683015	58455648	47	22277											
PMPCB	9512	broad.mit.edu	37	chr7	102952157	102952158	+	Frame_Shift_Ins	INS	-	T	T																															aaatcttctgaaaacaaacaINStgttgttgcagcttgatggt																										TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr7:102952157_102952158insT	uc003vbl.2	+	10	1256_1257	c.1222_1223insT	c.(1222-1224)ATGfs	p.M408fs	PMPCB_uc003vbk.1_Frame_Shift_Ins_p.M408fs|PMPCB_uc003vbm.2_Frame_Shift_Ins_p.M317fs|PMPCB_uc010liv.2_Frame_Shift_Ins_p.M314fs|PMPCB_uc010liw.2_Intron|PMPCB_uc011kll.1_Frame_Shift_Ins_p.M303fs|PMPCB_uc011klm.1_Frame_Shift_Ins_p.M283fs	NM_004279	NP_004270	O75439	MPPB_HUMAN	mitochondrial processing peptidase beta subunit	408					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4						GAAAACAAACATGTTGTTGCAG	0.356													---	---	---								T	102952158	T	T	102952157	7	5	125	1	0	1	1	0	0	0	0	0	12196	217	8	0	1260	0	PMPCB	7	102952157	Frame_Shift_Ins	INS	-	TCGA-CR-6477-01A-11D-1870-08	2269142	102952157	56186506	48	22278											
CSMD1	64478	broad.mit.edu	37	chr8	3265649	3265649	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcgacttcctggctccgagaTaatcaaccagacacagttca	12	9	7	13	2	2	2	2	0	0	2	5	4	4	2	3	1	1	2	3	1	2	3			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr8:3265649T>G	uc011kwk.1	-	14	2236	c.1846A>C	c.(1846-1848)ATC>CTC	p.I616L	CSMD1_uc011kwj.1_Missense_Mutation_p.I8L	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	616	Extracellular (Potential).|CUB 4.					integral to membrane		p.E616K(4)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGCTCCGAGATAATCAACCAG	0.403													5	23					0	0	0	0	G	3265649	G	G	3265649	3	3	125	1	0	0	0	0	1	0	0	0	3961	1406	49	5	9079	5	CSMD1	8	3265649	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08		3265649	143098373	49	22279											
RP1L1	94137	broad.mit.edu	37	chr8	10466397	10466397	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcaccctcgtccactccaggCccctggctcagccccggccc	4	6	8	23	2	2	0	2	0	0	0	5	0	4	0	8	3	1	1	8	3	0	0			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr8:10466397C>A	uc003wtc.2	-	4	5440	c.5211G>T	c.(5209-5211)GGG>GGT	p.G1737G		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1737					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCACTCCAGGCCCCTGGCTCA	0.657													12	123					1.08611e-07	1.15339e-07	1	0	A	10466397	A	A	10466397	2	1	125	1	0	0	0	0	0	0	0	1	13598	726	26	4		4	RP1L1	8	10466397	Silent	SNP	C	TCGA-CR-6477-01A-11D-1870-08	7200748	10466397	135897625	50	22280											
POTEA	340441	broad.mit.edu	37	chr8	43173712	43173712	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttagttccacaaagaaagagCagaaagcatgaaaatcagca	20	6	8	7	0	1	4	1	1	0	3	2	4	2	4	1	0	3	4	1	0	6	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr8:43173712C>T	uc003xpz.1	+	9	1177	c.1134C>T	c.(1132-1134)AGC>AGT	p.S378S	POTEA_uc003xqa.1_Silent_p.S332S	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	378										ovary(1)	1						AAAGAAAGAGCAGAAAGCATG	0.403													11	71					0	0	0	0	T	43173712	T	T	43173712	2	4	125	1	0	0	0	0	0	0	0	1	12316	709	25	4		4	POTEA	8	43173712	Silent	SNP	C	TCGA-CR-6477-01A-11D-1870-08	32707315	43173712	103190310	51	22281											
SLC25A32	81034	broad.mit.edu	37	chr8	104415406	104415406	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttaccttatataatccacGcacaccttcatacttatata	13	15	2	11	1	1	0	1	0	0	0	2	0	2	0	3	0	2	2	3	0	8	9			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr8:104415406G>A	uc003yll.2	-	4	841	c.538C>T	c.(538-540)CGT>TGT	p.R180C	SLC25A32_uc011lhr.1_Missense_Mutation_p.R48C	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	180	Solcar 2.				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	TATAATCCACGCACACCTTCA	0.318													3	27					0	0	0	0	A	104415406	A	A	104415406	3	1	125	1	0	0	0	0	1	0	0	0	14560	1087	38	1	425	1	SLC25A32	8	104415406	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	61241694	104415406	41948616	52	22282											
CSMD3	114788	broad.mit.edu	37	chr8	113347570	113347570	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ataccaaccgtgataactgaGcacaaaaaagccacttgttg	16	8	7	10	1	0	2	0	2	0	0	0	2	0	2	3	0	5	2	3	0	6	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr8:113347570G>A	uc003ynu.2	-	45	7312	c.7153C>T	c.(7153-7155)CTC>TTC	p.L2385F	CSMD3_uc003yns.2_Missense_Mutation_p.L1587F|CSMD3_uc003ynt.2_Missense_Mutation_p.L2345F|CSMD3_uc011lhx.1_Missense_Mutation_p.L2281F|CSMD3_uc003ynw.1_Missense_Mutation_p.L96F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2385	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGATAACTGAGCACAAAAAAG	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	28					0	0	0	0	A	113347570	A	A	113347570	3	1	125	1	0	0	0	0	1	0	0	0	3963	971	34	4	4078	4	CSMD3	8	113347570	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	8932164	113347570	33016452	53	22283											
TLE4	7091	broad.mit.edu	37	chr9	82320810	82320810	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttgtcaatgcaggacagcGatggtgagaaaagtgatgac	14	8	13	6	1	1	3	1	3	0	1	1	6	1	4	0	2	2	1	0	2	3	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr9:82320810G>T	uc004ald.2	+	10	1564	c.715G>T	c.(715-717)GAT>TAT	p.D239Y	TLE4_uc004alc.2_Missense_Mutation_p.D246Y|TLE4_uc010mpr.2_Missense_Mutation_p.D125Y|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Missense_Mutation_p.D214Y|TLE4_uc010mps.2_Intron|TLE4_uc004alf.2_Missense_Mutation_p.D185Y	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						GCAGGACAGCGATGGTGAGAA	0.398													48	65					3.76628e-20	4.22387e-20	1	0	T	82320810	T	T	82320810	3	4	125	1	0	0	0	0	1	0	0	0	16007	1058	37	3	774	3	TLE4	9	82320810	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08		82320810	58892621	54	22284											
AGAP6	414189	broad.mit.edu	37	chr10	51768861	51768861	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taggtgattatatgaagaatAttcataaaaaagagattgac	19	12	8	2	0	1	5	1	3	0	2	1	6	1	5	0	1	0	0	0	1	9	7			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr10:51768861A>G	uc001jix.3	+	8	1374	c.976A>G	c.(976-978)ATT>GTT	p.I326V		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	326					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						TATGAAGAATATTCATAAAAA	0.433													38	200					0	0	0	0	G	51768861	G	G	51768861	3	3	125	1	0	0	0	0	1	0	0	0	372	449	16	5	1006	5	AGAP6	10	51768861	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08		51768861	83765886	55	22285											
LZTS2	84445	broad.mit.edu	37	chr10	102763471	102763475	+	Frame_Shift_Del	DEL	AGTGG	-	-																															ctgacaaacccctggcatttAgtggctgggccagtggctgc																										TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr10:102763471_102763475delAGTGG	uc001ksj.2	+	3	685_689	c.616_620delAGTGG	c.(616-621)AGTGGCfs	p.S206fs	LZTS2_uc010qpw.1_Frame_Shift_Del_p.S206fs|LZTS2_uc001ksk.2_Frame_Shift_Del_p.S206fs|LZTS2_uc001ksl.2_Frame_Shift_Del_p.S206fs|LZTS2_uc001ksm.2_RNA	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	206_207	Ser-rich.|Required for centrosomal localization (By similarity).				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				ovary(2)|large_intestine(1)|breast(1)	4				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		CCTGGCATTTAGTGGCTGGGCCAGT	0.551													---	---	---								-	102763475	-	-	102763471	7	5	125	1	0	1	0	1	0	0	0	0	9190	420	15	0	622	0	LZTS2	10	102763471	Frame_Shift_Del	DEL	AGTGG	TCGA-CR-6477-01A-11D-1870-08	50994610	102763471	32771276	56	22286											
C10orf118	55088	broad.mit.edu	37	chr10	115923080	115923080	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaatctgctcctgatcttcGttttacatctaagaaattga	12	15	5	9	1	3	3	0	2	3	1	5	3	4	3	1	0	2	2	1	0	4	5			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr10:115923080G>A	uc001lbb.1	-	2	600	c.-52C>T	c.(-54--50)AACGA>AATGA		C10orf118_uc001lbc.1_Translation_Start_Site|C10orf118_uc009xye.1_RNA|C10orf118_uc001lbd.2_Translation_Start_Site|C10orf118_uc001lbe.2_Translation_Start_Site	NM_018017	NP_060487	Q7Z3E2	CJ118_HUMAN	CTCL tumor antigen L14-2											ovary(2)	2		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		CCTGATCTTCGTTTTACATCT	0.368													16	28					0	0	0	0	A	115923080	A	A	115923080	1	1	125	1	0	0	0	0	0	0	0	0	1593	1160	40	1		1	C10orf118	10	115923080	Translation_Start_Site	SNP	G	TCGA-CR-6477-01A-11D-1870-08	13159609	115923080	19611667	57	22287											
C10orf46	143384	broad.mit.edu	37	chr10	120513993	120513993	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccacggcggcggccgcgtcGcagctcttcaacatcatgat	7	7	12	15	6	3	1	2	1	1	0	4	1	3	1	2	3	2	2	2	3	1	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr10:120513993G>A	uc001lds.1	-	1	766	c.282C>T	c.(280-282)TGC>TGT	p.C94C	C10orf46_uc010qst.1_RNA	NM_153810	NP_722517	Q86Y37	CJ046_HUMAN	chromosome 10 open reading frame 46	94					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding				0		Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0131)		CGGCCGCGTCGCAGCTCTTCA	0.672													4	22					0	0	0	0	A	120513993	A	A	120513993	2	1	125	1	0	0	0	0	0	0	0	1	1610	1079	38	1		1	C10orf46	10	120513993	Silent	SNP	G	TCGA-CR-6477-01A-11D-1870-08	4590913	120513993	15020754	58	22288											
SEC23IP	11196	broad.mit.edu	37	chr10	121685722	121685722	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtgaattatgaatcttttGaagttggcgccggacaggtg	9	13	14	5	2	1	3	0	3	1	0	1	4	1	4	1	3	0	1	1	3	4	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr10:121685722G>A	uc001leu.1	+	13	2368	c.2296G>A	c.(2296-2298)GAA>AAA	p.E766K	SEC23IP_uc010qtc.1_Missense_Mutation_p.E555K|SEC23IP_uc009xzk.1_RNA	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	766					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TGAATCTTTTGAAGTTGGCGC	0.418													9	143					0	0	0	0	A	121685722	A	A	121685722	3	1	125	1	0	0	0	0	1	0	0	0	14058	1291	45	2	2346	2	SEC23IP	10	121685722	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	1171729	121685722	13849025	59	22289											
SPRYD5	84767	broad.mit.edu	37	chr11	55658878	55658878	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatagatggagaggagggaCtctttcttcttggatgtgtt	9	14	14	4	0	3	3	0	0	3	3	3	7	3	6	0	4	0	1	0	4	1	5			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr11:55658878C>A	uc010rip.1	+	7	1221	c.1129C>A	c.(1129-1131)CTC>ATC	p.L377I	SPRYD5_uc010riq.1_Missense_Mutation_p.L234I	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	377	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				AGAGGAGGGACTCTTTCTTCT	0.463													8	49					2.32078e-09	2.50896e-09	1	0	A	55658878	A	A	55658878	3	1	125	1	0	0	0	0	1	0	0	0	15177	565	20	4	1151	4	SPRYD5	11	55658878	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08		55658878	79347638	60	22290											
OR5J2	282775	broad.mit.edu	37	chr11	55945016	55945016	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaaagggccatagaaatgaAacatttcctctgttaatttc	15	12	7	7	0	1	2	0	1	1	1	3	3	2	2	2	1	1	1	2	1	6	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr11:55945016A>C	uc010rjb.1	+	1	923	c.923A>C	c.(922-924)AAA>ACA	p.K308T		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					ATAGAAATGAAACATTTCCTC	0.388													5	18					0	0	0	0	C	55945016	C	C	55945016	3	2	125	1	0	0	0	0	1	0	0	0	11219	14	1	5	925	5	OR5J2	11	55945016	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	286138	55945016	79061500	61	22291											
ACTN3	89	broad.mit.edu	37	chr11	66330402	66330402	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgagcaagttgtagcttccTtcaagatcttggcaggagac	10	11	11	9	0	2	3	1	1	1	2	3	4	3	3	1	2	2	5	1	2	3	5			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr11:66330402T>C	uc001oio.1	+	21	2542	c.2524T>C	c.(2524-2526)TTC>CTC	p.F842L	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	842					focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						TGTAGCTTCCTTCAAGATCTT	0.612													10	75					0	0	0	0	C	66330402	C	C	66330402	3	2	125	1	0	0	0	0	1	0	0	0	206	1609	56	5	2602	5	ACTN3	11	66330402	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08	10385386	66330402	68676114	62	22292											
SAPS3	55291	broad.mit.edu	37	chr11	68341612	68341612	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggcatggttacatgggacAcctaacgaggatagctaact	13	8	11	9	2	0	0	0	0	0	0	0	3	0	2	1	4	4	3	1	4	4	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr11:68341612A>G	uc001onw.2	+	13	1646	c.1379A>G	c.(1378-1380)CAC>CGC	p.H460R	SAPS3_uc001onv.2_Missense_Mutation_p.H460R|SAPS3_uc001ony.3_Missense_Mutation_p.H460R|SAPS3_uc001onx.2_Missense_Mutation_p.H460R|SAPS3_uc009ysh.2_Missense_Mutation_p.H409R|SAPS3_uc001onu.2_Missense_Mutation_p.H409R|SAPS3_uc010rqc.1_Missense_Mutation_p.H228R|SAPS3_uc010rqd.1_Missense_Mutation_p.H172R|SAPS3_uc001onz.2_5'Flank	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	460					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			TACATGGGACACCTAACGAGG	0.453													29	71					0	0	0	0	G	68341612	G	G	68341612	3	3	125	1	0	0	0	0	1	0	0	0	13903	159	6	5	1421	5	SAPS3	11	68341612	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	2011210	68341612	66664904	63	22293											
CPT1A	1374	broad.mit.edu	37	chr11	68571514	68571514	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaccggcaggcgaggcagcGatgtctggaagctgtacaac	10	5	16	10	3	1	0	0	0	1	0	1	4	1	2	1	5	4	4	1	5	3	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr11:68571514G>A	uc001oog.3	-	5	679	c.509C>T	c.(508-510)TCG>TTG	p.S170L	CPT1A_uc001oof.3_Missense_Mutation_p.S170L|CPT1A_uc009ysj.2_Missense_Mutation_p.S170L	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	170	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GCGAGGCAGCGATGTCTGGAA	0.458													7	54					0	0	0	0	A	68571514	A	A	68571514	3	1	125	1	0	0	0	0	1	0	0	0	3846	1059	37	1	1912	1	CPT1A	11	68571514	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	229902	68571514	66435002	64	22294											
NUMA1	4926	broad.mit.edu	37	chr11	71725761	71725761	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcccgggaggctgtttcctGctgctcacctgccttgcgca	3	11	11	16	2	1	0	1	0	0	0	3	1	3	1	4	2	4	5	4	2	0	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr11:71725761G>A	uc001orl.1	-	15	2960	c.2788C>T	c.(2788-2790)CAG>TAG	p.Q930*	NUMA1_uc009ysw.1_Nonsense_Mutation_p.Q493*|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Nonsense_Mutation_p.Q930*|NUMA1_uc001orn.2_Nonsense_Mutation_p.Q493*|NUMA1_uc009ysx.1_Nonsense_Mutation_p.Q930*|NUMA1_uc001oro.1_Nonsense_Mutation_p.Q930*	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	930	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						GCTGTTTCCTGCTGCTCACCT	0.607			T	RARA	APL								23	66					0	0	0	0	A	71725761	A	A	71725761	4	1	125	1	0	0	0	0	0	1	0	0	10804	1328	46	4	3611	4	NUMA1	11	71725761	Nonsense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	3154247	71725761	63280755	65	22295											
CHCHD8	51287	broad.mit.edu	37	chr11	73584274	73584274	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggctggcattgccgccaGtcctggtgctgggccatgca	4	10	15	12	1	0	0	0	0	0	0	1	0	1	0	4	4	3	4	4	4	0	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr11:73584274G>A	uc001ouj.2	-	2	255	c.150C>T	c.(148-150)GAC>GAT	p.D50D	CHCHD8_uc009ytw.2_RNA	NM_016565	NP_057649	Q9NYJ1	CHCH8_HUMAN	coiled-coil-helix-coiled-coil-helix domain	50	CHCH.										0	Breast(11;7.42e-05)					ATTGCCGCCAGTCCTGGTGCT	0.622													8	78					0	0	0	0	A	73584274	A	A	73584274	2	1	125	1	0	0	0	0	0	0	0	1	3337	1020	36	4		4	CHCHD8	11	73584274	Silent	SNP	G	TCGA-CR-6477-01A-11D-1870-08	1858513	73584274	61422242	66	22296											
OR10S1	219873	broad.mit.edu	37	chr11	123847715	123847715	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaagatgtaggaaataacGatgaggatgaggcagcctgc	15	7	14	5	1	0	4	0	3	0	1	0	7	0	6	1	3	3	2	1	3	4	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr11:123847715G>A	uc001pzm.1	-	1	684	c.684C>T	c.(682-684)ATC>ATT	p.I228I		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	228	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AGGAAATAACGATGAGGATGA	0.592													5	46					0	0	0	0	A	123847715	A	A	123847715	2	1	125	1	0	0	0	0	0	0	0	1	10972	1048	37	1		1	OR10S1	11	123847715	Silent	SNP	G	TCGA-CR-6477-01A-11D-1870-08	50263441	123847715	11158801	67	22297											
CPNE8	144402	broad.mit.edu	37	chr12	39069531	39069531	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctactcaccatcaaattctgCtggtccaacacctactataa	13	11	3	14	0	3	0	2	0	1	0	4	0	4	0	3	1	4	1	3	1	6	5			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr12:39069531C>T	uc001rls.1	-	18	1504	c.1420G>A	c.(1420-1422)GCA>ACA	p.A474T	CPNE8_uc001rlr.1_Missense_Mutation_p.A133T	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	474	VWFA.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				TCAAATTCTGCTGGTCCAACA	0.318													3	65					0	0	0	0	T	39069531	T	T	39069531	3	4	125	1	0	0	0	0	1	0	0	0	3833	797	28	4	286	4	CPNE8	12	39069531	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08		39069531	94782364	68	22298											
NUP37	79023	broad.mit.edu	37	chr12	102471261	102471261	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcataaaaccggattgttccAttcttctctgcaaccattag	11	14	5	11	1	3	0	1	0	2	0	5	1	4	1	3	1	3	2	3	1	4	6			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr12:102471261A>G	uc001tjc.2	-	6	626	c.561T>C	c.(559-561)AAT>AAC	p.N187N	NUP37_uc009zub.1_Silent_p.N187N	NM_024057	NP_076962	Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	187	WD 3.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			ovary(1)	1						GGATTGTTCCATTCTTCTCTG	0.363													9	68					0	0	0	0	G	102471261	G	G	102471261	2	3	125	1	0	0	0	0	0	0	0	1	10818	214	8	5		5	NUP37	12	102471261	Silent	SNP	A	TCGA-CR-6477-01A-11D-1870-08	63401730	102471261	31380634	69	22299											
PELI2	57161	broad.mit.edu	37	chr14	56755320	56755320	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcacggatattcgccgccGgatttgactcttccaaaaac	11	9	8	13	4	1	1	0	1	1	0	3	3	2	3	3	2	2	1	3	2	3	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr14:56755320G>T	uc001xch.2	+	4	761	c.475G>T	c.(475-477)GGA>TGA	p.G159*		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	159					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						ATTCGCCGCCGGATTTGACTC	0.438													11	27					9.05144e-12	9.8743e-12	1	0	T	56755320	T	T	56755320	4	4	125	1	0	0	0	0	0	1	0	0	11776	1117	39	3	489	3	PELI2	14	56755320	Nonsense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08		56755320	50594220	70	22300											
HIF1A	3091	broad.mit.edu	37	chr14	62203800	62203800	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccccagccgctggagacacaAtcatatctttagattttggc	10	11	8	12	1	2	2	1	0	1	2	2	3	2	2	3	2	1	1	3	2	3	5			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr14:62203800A>G	uc001xfq.2	+	9	1626	c.1222A>G	c.(1222-1224)ATC>GTC	p.I408V	HIF1A_uc001xfr.2_Missense_Mutation_p.I408V|HIF1A_uc001xfs.2_Missense_Mutation_p.I409V	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	408	N-terminal VHL recognition site.|ODD.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		TGGAGACACAATCATATCTTT	0.393													26	36					0	0	0	0	G	62203800	G	G	62203800	3	3	125	1	0	0	0	0	1	0	0	0	7142	101	4	5	1256	5	HIF1A	14	62203800	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	5448480	62203800	45145740	71	22301											
SYT16	83851	broad.mit.edu	37	chr14	62536483	62536483	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagaaaccaaaattcagccGttcgttgttgacacacggag	13	8	10	10	3	1	2	1	1	0	1	2	3	1	3	2	1	2	4	2	1	3	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr14:62536483G>A	uc001xfu.1	+	2	883	c.686G>A	c.(685-687)CGT>CAT	p.R229H	SYT16_uc010tsd.1_Missense_Mutation_p.R229H	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	229										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		AAATTCAGCCGTTCGTTGTTG	0.473													14	102					0	0	0	0	A	62536483	A	A	62536483	3	1	125	1	0	0	0	0	1	0	0	0	15538	1145	40	1	692	1	SYT16	14	62536483	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	332683	62536483	44813057	72	22302											
MPP5	64398	broad.mit.edu	37	chr14	67787776	67787776	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgattttgtttgcctagatAcaacccggagtaggcgagac	10	11	11	9	2	0	3	0	1	0	2	0	5	0	4	2	2	3	2	2	2	4	6			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr14:67787776A>G	uc001xjc.2	+	13	2006	c.1540A>G	c.(1540-1542)ACA>GCA	p.T514A	MPP5_uc001xjd.2_Missense_Mutation_p.T480A|ATP6V1D_uc001xje.2_Intron	NM_022474	NP_071919	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5	514	Guanylate kinase-like.				tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			ovary(1)	1				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		TTGCCTAGATACAACCCGGAG	0.438													3	84					0	0	0	0	G	67787776	G	G	67787776	3	3	125	1	0	0	0	0	1	0	0	0	9790	391	14	5	1582	5	MPP5	14	67787776	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	5251293	67787776	39561764	73	22303											
GALNTL1	57452	broad.mit.edu	37	chr14	69805441	69805441	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccgggtgggccatgtcttCaggaaacggcacccctacaa	10	6	12	13	2	2	0	1	0	1	0	2	1	2	1	4	4	3	1	4	4	3	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr14:69805441C>T	uc010aqu.1	+	10	1134	c.1041C>T	c.(1039-1041)TTC>TTT	p.F347F	GALNTL1_uc001xla.1_Silent_p.F347F|GALNTL1_uc001xlb.1_Silent_p.F347F	NM_020692	NP_065743	Q8N428	GLTL1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	347	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)		GCCATGTCTTCAGGAAACGGC	0.483													5	89					0	0	0	0	T	69805441	T	T	69805441	2	4	125	1	0	0	0	0	0	0	0	1	6256	825	29	2		2	GALNTL1	14	69805441	Silent	SNP	C	TCGA-CR-6477-01A-11D-1870-08	2017665	69805441	37544099	74	22304											
KIAA0247	9766	broad.mit.edu	37	chr14	70175480	70175481	+	Frame_Shift_Ins	INS	-	T	T																															tcatacgaggaggctgtataINStggcagttctggtcactgtg																										TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr14:70175480_70175481insT	uc001xlk.2	+	5	861_862	c.545_546insT	c.(544-546)TATfs	p.Y182fs	KIAA0247_uc010aqz.2_Frame_Shift_Ins_p.Y157fs	NM_014734	NP_055549	Q92537	K0247_HUMAN	hypothetical protein LOC9766 precursor	182	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3				all cancers(60;0.00155)|BRCA - Breast invasive adenocarcinoma(234;0.0164)|OV - Ovarian serous cystadenocarcinoma(108;0.0196)		GAGGCTGTATATGGCAGTTCTG	0.589													---	---	---								T	70175481	T	T	70175480	7	5	125	1	0	1	1	0	0	0	0	0	8204	449	16	0	559	0	KIAA0247	14	70175480	Frame_Shift_Ins	INS	-	TCGA-CR-6477-01A-11D-1870-08	370039	70175480	37174060	75	22305											
MYO9A	4649	broad.mit.edu	37	chr15	72227761	72227761	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctttatcaagcaaggaggTgccacttgatagtctgctct	10	13	9	9	0	4	1	1	1	3	0	4	2	4	2	1	2	3	2	1	2	4	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr15:72227761T>A	uc002atl.3	-	17	2916	c.2443A>T	c.(2443-2445)ACC>TCC	p.T815S	MYO9A_uc010biq.2_Missense_Mutation_p.T435S|MYO9A_uc002atn.1_Missense_Mutation_p.T796S	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	815					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						AGCAAGGAGGTGCCACTTGAT	0.393													13	76					0	0	0	0	A	72227761	A	A	72227761	3	1	125	1	0	0	0	0	1	0	0	0	10137	1696	59	5	5307	5	MYO9A	15	72227761	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08		72227761	30303631	76	22306											
ABCA3	21	broad.mit.edu	37	chr16	2369816	2369816	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggtccacagcatgctgcacGgccaggaagccttcccggat	8	6	12	15	3	0	0	0	0	0	0	2	2	2	2	4	4	4	3	4	4	1	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr16:2369816G>A	uc002cpy.1	-	8	1351	c.639C>T	c.(637-639)GCC>GCT	p.A213A	ABCA3_uc010bsk.1_Silent_p.A213A|ABCA3_uc010bsl.1_Silent_p.A213A	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	213					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CATGCTGCACGGCCAGGAAGC	0.652													10	66					0	0	0	0	A	2369816	A	A	2369816	2	1	125	1	0	0	0	0	0	0	0	1	33	1103	39	1		1	ABCA3	16	2369816	Silent	SNP	G	TCGA-CR-6477-01A-11D-1870-08		2369816	87984937	77	22307											
ACSM5	54988	broad.mit.edu	37	chr16	20442585	20442585	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctgcctcctggagaagaggGgaatgttgccgtccgtatca	8	9	13	11	2	1	2	1	0	0	2	3	4	3	3	5	3	2	2	5	3	3	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr16:20442585G>A	uc002dhe.2	+	10	1397	c.1250G>A	c.(1249-1251)GGG>GAG	p.G417E		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	417					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						GGAGAAGAGGGGAATGTTGCC	0.507													18	151					0	0	0	0	A	20442585	A	A	20442585	3	1	125	1	0	0	0	0	1	0	0	0	187	1232	43	4	1284	4	ACSM5	16	20442585	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	18072769	20442585	69912168	78	22308											
ITFG1	81533	broad.mit.edu	37	chr16	47294551	47294551	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaaacattcgacgcgcctCttcacagcttgcattattac	10	14	5	12	3	2	0	1	0	1	0	3	1	2	0	1	0	4	2	1	0	4	7			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr16:47294551C>G	uc002eet.2	-	11	1188	c.1126G>C	c.(1126-1128)GAG>CAG	p.E376Q	ITFG1_uc010vgg.1_Missense_Mutation_p.E121Q|ITFG1_uc010vgh.1_Missense_Mutation_p.E263Q	NM_030790	NP_110417	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	376						extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				CGACGCGCCTCTTCACAGCTT	0.438													7	71					0	0	0	0	G	47294551	G	G	47294551	3	3	125	1	0	0	0	0	1	0	0	0	7908	922	32	2	744	2	ITFG1	16	47294551	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	26851966	47294551	43060202	79	22309											
CES2	8824	broad.mit.edu	37	chr16	66969474	66969474	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccactgctggacagaccCggggcagcctctgggtgaac	8	6	14	13	1	1	2	0	1	1	1	2	4	2	3	3	4	3	2	3	4	1	0			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr16:66969474C>A	uc002eqr.2	+	1	1128	c.128C>A	c.(127-129)CCG>CAG	p.P43Q	CES2_uc002eqq.2_Missense_Mutation_p.P43Q|CES2_uc002eqs.2_5'UTR|FAM96B_uc002eqp.2_5'Flank	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	Error:Variant_position_missing_in_O00748_after_alignment					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		TGGACAGACCCGGGGCAGCCT	0.682													10	78					2.17888e-05	2.29355e-05	1	0	A	66969474	A	A	66969474	3	1	125	1	0	0	0	0	1	0	0	0	3285	652	23	3	130	3	CES2	16	66969474	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	19674923	66969474	23385279	80	22310											
CENPT	80152	broad.mit.edu	37	chr16	67863714	67863714	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaagatgctcctggcccGtcagcctcagcagtcccctg	6	8	10	17	1	2	2	2	1	0	1	4	2	4	2	6	1	3	2	6	1	1	0			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr16:67863714G>A	uc002eun.3	-	12	1689	c.1140C>T	c.(1138-1140)GAC>GAT	p.D380D	CENPT_uc002eum.3_Intron|CENPT_uc010vkc.1_Silent_p.D138D|CENPT_uc010vkd.1_Silent_p.D133D|CENPT_uc010vke.1_3'UTR	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	380					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		CTCCTGGCCCGTCAGCCTCAG	0.612													4	143					0	0	0	0	A	67863714	A	A	67863714	2	1	125	1	0	0	0	0	0	0	0	1	3257	1136	40	1		1	CENPT	16	67863714	Silent	SNP	G	TCGA-CR-6477-01A-11D-1870-08	894240	67863714	22491039	81	22311											
USP6	9098	broad.mit.edu	37	chr17	5042701	5042701	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccccgccatgggcatctcgTttttccacgccctgtcctgg	3	12	9	17	3	1	0	0	0	1	0	5	0	4	0	6	2	0	2	6	2	0	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr17:5042701T>G	uc002gau.1	+	22	3460	c.1230T>G	c.(1228-1230)CGT>CGG	p.R410R	USP6_uc002gav.1_Silent_p.R410R|USP6_uc010ckz.1_Silent_p.R93R|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	410					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						GGGCATCTCGTTTTTCCACGC	0.662			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								6	53					0	0	0	0	G	5042701	G	G	5042701	2	3	125	1	0	0	0	0	0	0	0	1	17154	1712	60	5		5	USP6	17	5042701	Silent	SNP	T	TCGA-CR-6477-01A-11D-1870-08		5042701	76152509	82	22312											
TP53	7157	broad.mit.edu	37	chr17	7574003	7574003	+	Frame_Shift_Del	DEL	G	-	-																															caaggcctcattcagctctcGgaacatctcgaagcgctcac																										TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr17:7574003delG	uc002gim.2	-	10	1218	c.1024delC	c.(1024-1026)CGAfs	p.R342fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Frame_Shift_Del_p.R210fs|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Frame_Shift_Del_p.R342fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	342	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Nuclear export signal.|Interaction with HIPK2.		R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R342*(49)|p.0?(7)|p.R342fs*3(5)|p.R342P(3)|p.R342Q(2)|p.?(1)|p.R342_N345delRELN(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCAGCTCTCGGAACATCTCG	0.498		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7574003	-	-	7574003	7	5	125	1	0	1	0	1	0	0	0	0	16448	1124	39	0	165	0	TP53	17	7574003	Frame_Shift_Del	DEL	G	TCGA-CR-6477-01A-11D-1870-08	2531302	7574003	73621207	83	22313											
MYH1	4619	broad.mit.edu	37	chr17	10398332	10398332	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacgatgctgcaggtccttCaccgtctgttccaggttctt	6	13	10	12	2	3	1	1	0	2	1	5	2	5	1	3	2	2	4	3	2	0	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr17:10398332C>T	uc002gmo.2	-	37	5476	c.5382G>A	c.(5380-5382)GTG>GTA	p.V1794V	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1794	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GCAGGTCCTTCACCGTCTGTT	0.557													27	146					0	0	0	0	T	10398332	T	T	10398332	2	4	125	1	0	0	0	0	0	0	0	1	10082	813	29	2		2	MYH1	17	10398332	Silent	SNP	C	TCGA-CR-6477-01A-11D-1870-08	2824329	10398332	70796878	84	22314											
MYH1	4619	broad.mit.edu	37	chr17	10408543	10408543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctgcacatggcctgggttCgggtaatcagctgggccagc	6	9	14	12	1	2	0	1	0	1	0	3	0	2	0	2	4	3	4	2	4	1	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr17:10408543C>T	uc002gmo.2	-	21	2466	c.2372G>A	c.(2371-2373)CGA>CAA	p.R791Q	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	791	IQ.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GGCCTGGGTTCGGGTAATCAG	0.458													34	49					0	0	0	0	T	10408543	T	T	10408543	3	4	125	1	0	0	0	0	1	0	0	0	10082	884	31	1	3527	1	MYH1	17	10408543	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	10211	10408543	70786667	85	22315											
ANKRD13B	124930	broad.mit.edu	37	chr17	27937744	27937744	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagctcatcacccgcacacgGacagaacatctttcagaaca	14	6	7	14	2	4	2	3	0	1	2	4	4	4	3	1	1	3	2	1	1	2	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr17:27937744G>A	uc002hei.2	+	8	977	c.864G>A	c.(862-864)CGG>CGA	p.R288R	ANKRD13B_uc002heh.2_Silent_p.R156R|ANKRD13B_uc002hej.2_RNA|ANKRD13B_uc002hek.2_5'Flank	NM_152345	NP_689558	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	288											0						CCCGCACACGGACAGAACATC	0.542													6	45					0	0	0	0	A	27937744	A	A	27937744	2	1	125	1	0	0	0	0	0	0	0	1	642	1161	41	2		2	ANKRD13B	17	27937744	Silent	SNP	G	TCGA-CR-6477-01A-11D-1870-08	17529201	27937744	53257466	86	22316											
SLC39A6	25800	broad.mit.edu	37	chr18	33703502	33703502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcaccactcaaagtcccaaCggccagtgccacaaggaaac	15	4	7	15	1	2	0	2	0	0	0	3	1	3	1	4	2	3	0	4	2	4	0			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr18:33703502C>T	uc010dmy.2	-	4	1386	c.1096G>A	c.(1096-1098)GTT>ATT	p.V366I	SLC39A6_uc002kzj.2_Missense_Mutation_p.V91I	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	366	Helical; Name=2; (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						AAAGTCCCAACGGCCAGTGCC	0.393													22	190					0	0	0	0	T	33703502	T	T	33703502	3	4	125	1	0	0	0	0	1	0	0	0	14686	536	19	1	1211	1	SLC39A6	18	33703502	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08		33703502	44373746	87	22317											
ADAMTSL5	339366	broad.mit.edu	37	chr19	1507298	1507299	+	Frame_Shift_Del	DEL	TG	-	-																															tgcaatgtctcctggggcccTgtgtctcgggtgtagaccac																										TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr19:1507298_1507299delTG	uc002ltd.2	-	9	1238_1239	c.794_795delCA	c.(793-795)ACAfs	p.T265fs	ADAMTSL5_uc010dsl.2_Frame_Shift_Del_p.T34fs|ADAMTSL5_uc010xgq.1_Frame_Shift_Del_p.T275fs	NM_213604	NP_998769	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5 precursor	265						proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGGGGCCCTGTGTCTCGGGT	0.673													---	---	---								-	1507299	-	-	1507298	7	5	125	1	0	1	0	1	0	0	0	0	278	1567	55	0	636	0	ADAMTSL5	19	1507298	Frame_Shift_Del	DEL	TG	TCGA-CR-6477-01A-11D-1870-08		1507298	57621685	88	22318											
PRR12	57479	broad.mit.edu	37	chr19	50099892	50099892	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaagagccctccgccccCacctcccacggcccagtcta	9	4	7	21	2	1	1	0	0	1	1	3	1	3	1	7	1	1	1	7	1	3	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr19:50099892C>T	uc002poo.3	+	4	2300	c.2300C>T	c.(2299-2301)CCA>CTA	p.P767L		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	475	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CCTCCGCCCCCACCTCCCACG	0.721													3	23					0	0	0	0	T	50099892	T	T	50099892	3	4	125	1	0	0	0	0	1	0	0	0	12646	594	21	4	2314	4	PRR12	19	50099892	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	48592594	50099892	9029091	89	22319											
UMODL1	89766	broad.mit.edu	37	chr21	43536021	43536025	+	Frame_Shift_Del	DEL	GTCAG	-	-																															gaaaggtcagaatcaaaaatGtcaggtactcagaatccttt																										TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr21:43536021_43536025delGTCAG	uc002zaf.1	+	14	2401_2405	c.2401_2405delGTCAG	c.(2401-2406)GTCAGGfs	p.V801fs	UMODL1_uc002zad.1_Frame_Shift_Del_p.V729fs|UMODL1_uc002zae.1_Frame_Shift_Del_p.V857fs|UMODL1_uc002zag.1_Frame_Shift_Del_p.V929fs	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	801_802	Extracellular (Potential).|SEA 2.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						AATCAAAAATGTCAGGTACTCAGAA	0.434													---	---	---								-	43536025	-	-	43536021	7	5	125	1	0	1	0	1	0	0	0	0	17048	1377	48	0	2835	0	UMODL1	21	43536021	Frame_Shift_Del	DEL	GTCAG	TCGA-CR-6477-01A-11D-1870-08		43536021	4593874	90	22320											
MN1	4330	broad.mit.edu	37	chr22	28193871	28193871	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gacgggcctccgggtcctggGgccccaggagcagtccctcc	4	5	15	17	2	0	0	0	0	0	0	4	2	4	1	7	5	1	1	7	5	0	0			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr22:28193871G>A	uc003adj.2	-	1	3616	c.2661C>T	c.(2659-2661)GCC>GCT	p.A887A		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	887							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						CGGGTCCTGGGGCCCCAGGAG	0.711			T	ETV6	AML|meningioma								14	18					0	0	0	0	A	28193871	A	A	28193871	2	1	125	1	0	0	0	0	0	0	0	1	9726	1219	43	4		4	MN1	22	28193871	Silent	SNP	G	TCGA-CR-6477-01A-11D-1870-08		28193871	23110695	91	22321											
SLC5A1	6523	broad.mit.edu	37	chr22	32487710	32487710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggacatctacgccaaggtccGcaagagagcatctgagaaag	14	5	12	10	2	2	2	0	1	2	2	3	5	3	3	2	2	2	2	2	2	4	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chr22:32487710G>A	uc003amc.2	+	11	1473	c.1241G>A	c.(1240-1242)CGC>CAC	p.R414H	SLC5A1_uc011alz.1_Missense_Mutation_p.R287H	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	414	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						GCCAAGGTCCGCAAGAGAGCA	0.522													33	42					0	0	0	0	A	32487710	A	A	32487710	3	1	125	1	0	0	0	0	1	0	0	0	14725	1087	38	1	1283	1	SLC5A1	22	32487710	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	4293839	32487710	18816856	92	22322											
CDKL5	6792	broad.mit.edu	37	chrX	18593592	18593592	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggggaaagttgtacttggtGtttgagtatgttgaaaaagt	12	14	14	1	0	0	2	0	2	0	0	0	3	0	3	0	3	1	5	0	3	5	6			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:18593592G>C	uc004cym.2	+	5	517	c.264G>C	c.(262-264)GTG>GTC	p.V88V	CDKL5_uc004cyn.2_Silent_p.V88V	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	88	Protein kinase.				neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					TGTACTTGGTGTTTGAGTATG	0.378													26	91					0	0	0	0	C	18593592	C	C	18593592	2	2	125	1	0	0	0	0	0	0	0	1	3172	1364	48	4		4	CDKL5	23	18593592	Silent	SNP	G	TCGA-CR-6477-01A-11D-1870-08		18593592	136676968	93	22323											
PDHA1	5160	broad.mit.edu	37	chrX	19377655	19377655	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaggatgctgcccagtttGccacggccgatcctgagcca	7	9	12	13	2	0	2	0	2	0	0	1	4	1	3	5	2	4	2	5	2	0	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:19377655G>A	uc004czg.3	+	11	1202	c.1057G>A	c.(1057-1059)GCC>ACC	p.A353T	PDHA1_uc004czh.3_Missense_Mutation_p.A388T|PDHA1_uc011mjc.1_Missense_Mutation_p.A357T|PDHA1_uc011mjd.1_Missense_Mutation_p.A319T|PDHA1_uc010nfk.2_Missense_Mutation_p.A291T|PDHA1_uc010nfl.2_Missense_Mutation_p.A144T	NM_000284	NP_000275	P08559	ODPA_HUMAN	pyruvate dehydrogenase E1 alpha 1 precursor	353					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)	1	Hepatocellular(33;0.183)				NADH(DB00157)	TGCCCAGTTTGCCACGGCCGA	0.473													42	93					0	0	0	0	A	19377655	A	A	19377655	3	1	125	1	0	0	0	0	1	0	0	0	11718	1319	46	4	1238	4	PDHA1	23	19377655	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	784063	19377655	135892905	94	22324											
DMD	1756	broad.mit.edu	37	chrX	31950341	31950341	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagatattcttttgttcttcTagcctggagaaagaagaata	14	14	8	5	0	3	4	0	0	3	4	3	5	3	4	1	1	1	1	1	1	7	8			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:31950341T>C	uc004dda.1	-	46	6862	c.6618A>G	c.(6616-6618)CTA>CTG	p.L2206L	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Silent_p.L862L|DMD_uc004dcx.2_Silent_p.L865L|DMD_uc004dcz.2_Silent_p.L2083L|DMD_uc004dcy.1_Silent_p.L2202L|DMD_uc004ddb.1_Silent_p.L2198L|DMD_uc010ngo.1_Silent_p.L115L|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2206	Spectrin 15.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTTGTTCTTCTAGCCTGGAGA	0.303													8	44					0	0	0	0	C	31950341	C	C	31950341	2	2	125	1	0	0	0	0	0	0	0	1	4602	1509	53	5		5	DMD	23	31950341	Silent	SNP	T	TCGA-CR-6477-01A-11D-1870-08	12572686	31950341	123320219	95	22325											
CCNB3	85417	broad.mit.edu	37	chrX	50028249	50028249	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcccagtcatcatgaccCatctgaaaaggttagagcaa	13	9	9	10	0	3	3	2	2	1	1	3	3	3	3	2	1	2	2	2	1	4	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:50028249C>T	uc004dox.3	+	3	384	c.86C>T	c.(85-87)CCA>CTA	p.P29L	CCNB3_uc004doy.2_Missense_Mutation_p.P29L|CCNB3_uc004doz.2_Missense_Mutation_p.P29L|CCNB3_uc010njq.2_5'UTR	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	29					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CATCATGACCCATCTGAAAAG	0.458													6	75					0	0	0	0	T	50028249	T	T	50028249	3	4	125	1	0	0	0	0	1	0	0	0	2929	594	21	4	88	4	CCNB3	23	50028249	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	18077908	50028249	105242311	96	22326											
ITIH5L	347365	broad.mit.edu	37	chrX	54783977	54783977	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggggtcttggacaagaggaTtccaggccccaggtgtggca	9	7	16	9	0	1	1	0	0	1	1	2	3	2	3	3	7	0	1	3	7	1	2			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:54783977T>C	uc004dtj.2	-	8	2560	c.2530A>G	c.(2530-2532)ATC>GTC	p.I844V		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	844	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GACAAGAGGATTCCAGGCCCC	0.507													37	113					0	0	0	0	C	54783977	C	C	54783977	3	2	125	1	0	0	0	0	1	0	0	0	7947	1493	52	5	1435	5	ITIH5L	23	54783977	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08	4755728	54783977	100486583	97	22327											
FAM123B	139285	broad.mit.edu	37	chrX	63410937	63410937	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtgaataagtagggtaggCcctcctgggagatcctccaa	10	8	14	9	0	0	2	0	1	0	1	3	3	3	2	4	4	0	2	4	4	5	3			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:63410937C>G	uc004dvo.2	-	2	2503	c.2230G>C	c.(2230-2232)GCC>CCC	p.A744P		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	744					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GTAGGGTAGGCCCTCCTGGGA	0.502													26	58					0	0	0	0	G	63410937	G	G	63410937	3	3	125	1	0	0	0	0	1	0	0	0	5451	739	26	4	1181	4	FAM123B	23	63410937	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	8626960	63410937	91859623	98	22328											
BRWD3	254065	broad.mit.edu	37	chrX	79988994	79988994	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaacagcaacaactttaTcctaagacatgaaacagatt	18	9	5	9	0	0	4	0	2	0	2	1	4	1	4	1	0	5	1	1	0	6	4			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:79988994T>C	uc004edt.2	-	12	1351	c.1088A>G	c.(1087-1089)GAT>GGT	p.D363G	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_Missense_Mutation_p.D192G|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_5'UTR|BRWD3_uc004edr.2_Missense_Mutation_p.D33G|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_Missense_Mutation_p.D33G|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_Missense_Mutation_p.D33G|BRWD3_uc004eea.2_Missense_Mutation_p.D33G|BRWD3_uc004eeb.2_5'UTR	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	363	WD 6.									ovary(4)	4						AACAACTTTATCCTAAGACAT	0.299													6	108					0	0	0	0	C	79988994	C	C	79988994	3	2	125	1	0	0	0	0	1	0	0	0	1531	1449	50	5	4440	5	BRWD3	23	79988994	Missense_Mutation	SNP	T	TCGA-CR-6477-01A-11D-1870-08	16578057	79988994	75281566	99	22329											
PCDH11X	27328	broad.mit.edu	37	chrX	91133770	91133770	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcaccacaccttaaggCtgctcagaaaaacaagcaga	16	4	8	13	0	1	2	1	0	0	2	1	2	1	2	3	2	3	4	3	2	4	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:91133770C>A	uc004efk.1	+	2	3376	c.2531C>A	c.(2530-2532)GCT>GAT	p.A844D	PCDH11X_uc004efl.1_Missense_Mutation_p.A844D|PCDH11X_uc004efo.1_Missense_Mutation_p.A844D|PCDH11X_uc010nmv.1_Missense_Mutation_p.A844D|PCDH11X_uc004efm.1_Missense_Mutation_p.A844D|PCDH11X_uc004efn.1_Missense_Mutation_p.A844D|PCDH11X_uc004efh.1_Missense_Mutation_p.A844D|PCDH11X_uc004efj.1_Missense_Mutation_p.A844D	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	844	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CACCTTAAGGCTGCTCAGAAA	0.403													45	107					2.79147e-13	3.07317e-13	1	0	A	91133770	A	A	91133770	3	1	125	1	0	0	0	0	1	0	0	0	11562	797	28	4	2537	4	PCDH11X	23	91133770	Missense_Mutation	SNP	C	TCGA-CR-6477-01A-11D-1870-08	11144776	91133770	64136790	100	22330											
UPF3B	65109	broad.mit.edu	37	chrX	118985732	118985732	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttttttttttttttacctCgtatcattagaaaaaaactc	11	22	2	6	1	1	1	1	0	0	1	3	1	1	1	1	0	2	1	1	0	6	10			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:118985732C>T	uc004erz.1	-	2	338	c.261G>A	c.(259-261)ACG>ACA	p.T87T	UPF3B_uc004esa.1_Silent_p.T87T	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	87	Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						TTTTTTACCTCGTATCATTAG	0.318													7	8					0	0	0	0	T	118985732	T	T	118985732	2	4	125	1	0	0	0	0	0	0	0	1	17074	871	31	1		1	UPF3B	23	118985732	Silent	SNP	C	TCGA-CR-6477-01A-11D-1870-08	27851962	118985732	36284828	101	22331											
ODZ1	10178	broad.mit.edu	37	chrX	123514615	123514615	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gggccactgcgcgctgtctgGcaatctccaacacgtgattc	7	9	11	14	3	2	1	0	1	2	0	4	1	2	1	2	2	2	2	2	2	2	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:123514615G>A	uc004euj.2	-	31	8013	c.7949C>T	c.(7948-7950)GCC>GTC	p.A2650V	ODZ1_uc011muj.1_Missense_Mutation_p.A2656V|ODZ1_uc010nqy.2_Missense_Mutation_p.A2657V	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2650	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GCGCTGTCTGGCAATCTCCAA	0.542													4	195					0	0	0	0	A	123514615	A	A	123514615	3	1	125	1	0	0	0	0	1	0	0	0	10888	1203	42	4	232	4	ODZ1	23	123514615	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	4528883	123514615	31755945	102	22332											
ARHGAP36	158763	broad.mit.edu	37	chrX	130218939	130218939	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtgctggatgacaatcagAatgtgcatgatgtggctgca	11	11	13	6	0	1	3	1	2	0	1	1	4	1	4	0	2	3	4	0	2	3	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:130218939A>C	uc004evz.2	+	7	1201	c.856A>C	c.(856-858)AAT>CAT	p.N286H	ARHGAP36_uc004ewa.2_Missense_Mutation_p.N274H|ARHGAP36_uc004ewb.2_Missense_Mutation_p.N255H|ARHGAP36_uc004ewc.2_Missense_Mutation_p.N150H	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	286	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						TGACAATCAGAATGTGCATGA	0.498													63	268					0	0	0	0	C	130218939	C	C	130218939	3	2	125	1	0	0	0	0	1	0	0	0	883	246	9	5	878	5	ARHGAP36	23	130218939	Missense_Mutation	SNP	A	TCGA-CR-6477-01A-11D-1870-08	6704324	130218939	25051621	103	22333											
ZIC3	7547	broad.mit.edu	37	chrX	136649736	136649736	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccggagcagaacaaccacGtctgctactgggaggagtgc	10	5	14	12	2	1	1	0	0	1	1	1	4	1	4	2	3	6	2	2	3	3	1			TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:136649736G>A	uc004fak.2	+	1	1391	c.886G>A	c.(886-888)GTC>ATC	p.V296I		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	296	C2H2-type 2; atypical.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GAACAACCACGTCTGCTACTG	0.612													31	101					0	0	0	0	A	136649736	A	A	136649736	3	1	125	1	0	0	0	0	1	0	0	0	17747	1145	40	1	888	1	ZIC3	23	136649736	Missense_Mutation	SNP	G	TCGA-CR-6477-01A-11D-1870-08	6430797	136649736	18620824	104	22334											
SPANXN3	139067	broad.mit.edu	37	chrX	142605149	142605149	+	Frame_Shift_Del	DEL	T	-	-																															ctgacaatcttacctcatcaTtttttttgttattggattca																										TCGA-CR-6477-01A-11D-1870-08	TCGA-CR-6477-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e02f3646-a500-4781-ad44-2f62661a883d	b9f8b4a2-7383-4f08-bd9d-8acb786f01c3	g.chrX:142605149delT	uc004fbw.2	-	1	159	c.71delA	c.(70-72)AATfs	p.N24fs		NM_001009609	NP_001009609	Q5MJ09	SPXN3_HUMAN	SPANX-N3 protein	24										ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TACCTCATCATTTTTTTTGTT	0.239													---	---	---								-	142605149	-	-	142605149	7	5	125	1	0	1	0	1	0	0	0	0	15058	1493	52	0	362	0	SPANXN3	23	142605149	Frame_Shift_Del	DEL	T	TCGA-CR-6477-01A-11D-1870-08	5955413	142605149	12665411	105	22335											
ECE1	1889	broad.mit.edu	37	chr1	21599368	21599368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaagatggagctggtcactGagacacaagcttcgctcagg	11	8	12	10	1	3	2	3	1	0	2	4	4	3	3	0	3	2	3	0	3	2	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:21599368G>A	uc001bek.2	-	4	392	c.317C>T	c.(316-318)TCA>TTA	p.S106L	ECE1_uc001bem.2_Missense_Mutation_p.S90L|ECE1_uc001bej.2_Missense_Mutation_p.S94L|ECE1_uc001bei.2_Missense_Mutation_p.S103L|ECE1_uc010odl.1_Missense_Mutation_p.S106L|ECE1_uc009vqa.1_Missense_Mutation_p.S106L	NM_001397	NP_001388	P42892	ECE1_HUMAN	endothelin converting enzyme 1 isoform 1	106	Extracellular (Potential).				bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			ovary(2)|skin(1)	3		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		GCTGGTCACTGAGACACAAGC	0.597													10	80					0	0	0	0	A	21599368	A	A	21599368	3	1	126	1	0	0	0	0	1	0	0	0	4911	1294	45	2	2059	2	ECE1	1	21599368	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08		21599368	227651253	1	22336											
MECR	51102	broad.mit.edu	37	chr1	29557401	29557401	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggggttcgcacccgccacagGgtactgcagacccacatgct	8	6	12	15	2	0	1	0	0	0	1	1	1	0	1	3	3	3	5	3	3	1	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:29557401G>A	uc001brq.1	-	1	54	c.18C>T	c.(16-18)ACC>ACT	p.T6T	MECR_uc001brp.1_5'UTR|MECR_uc001brr.1_5'UTR|MECR_uc001brs.1_RNA|MECR_uc001brt.1_5'UTR|MECR_uc010ofz.1_Silent_p.T6T	NM_016011	NP_057095	Q9BV79	MECR_HUMAN	trans-2-enoyl-CoA reductase, mitochondrial	6					fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			ovary(1)	1		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		CCCGCCACAGGGTACTGCAGA	0.721													3	27					0	0	0	0	A	29557401	A	A	29557401	2	1	126	1	0	0	0	0	0	0	0	1	9477	1219	43	4		4	MECR	1	29557401	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	7958033	29557401	219693220	2	22337											
ZMYM4	9202	broad.mit.edu	37	chr1	35859302	35859302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacacagactaaagccacctCttgcaaaccacatacccaaa	17	5	3	16	0	1	1	0	0	1	1	1	1	1	1	4	0	4	1	4	0	5	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:35859302C>T	uc001byt.2	+	18	2953	c.2873C>T	c.(2872-2874)TCT>TTT	p.S958F	ZMYM4_uc009vuu.2_Missense_Mutation_p.S926F|ZMYM4_uc001byu.2_Missense_Mutation_p.S634F|ZMYM4_uc009vuv.2_Missense_Mutation_p.S697F	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	958					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAAGCCACCTCTTGCAAACCA	0.398													11	88					0	0	0	0	T	35859302	T	T	35859302	3	4	126	1	0	0	0	0	1	0	0	0	17769	913	32	2	2943	2	ZMYM4	1	35859302	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	6301901	35859302	213391319	3	22338											
EBNA1BP2	10969	broad.mit.edu	37	chr1	43637162	43637162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaacatacaaactcatctctCgctggaagtcgtcttctgga	12	11	7	11	2	4	0	1	0	3	0	7	2	4	2	0	2	3	1	0	2	4	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:43637162C>T	uc001cin.2	-	3	508	c.311G>A	c.(310-312)CGA>CAA	p.R104Q	EBNA1BP2_uc001cio.2_Missense_Mutation_p.R159Q|WDR65_uc010ojz.1_5'Flank|WDR65_uc001cip.1_5'Flank|WDR65_uc001ciq.1_5'Flank|EBNA1BP2_uc001cim.2_5'UTR|EBNA1BP2_uc010ojx.1_Missense_Mutation_p.R159Q	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	104					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACTCATCTCTCGCTGGAAGTC	0.493													15	126					0	0	0	0	T	43637162	T	T	43637162	3	4	126	1	0	0	0	0	1	0	0	0	4907	884	31	1	637	1	EBNA1BP2	1	43637162	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	7777860	43637162	205613459	4	22339											
UROD	7389	broad.mit.edu	37	chr1	45478996	45478996	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccctctggatgctgccatCattttctccgacatccttgt	5	16	6	14	1	3	0	1	0	2	0	6	2	5	1	4	1	2	1	4	1	0	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:45478996C>T	uc001cna.1	+	4	354	c.246C>T	c.(244-246)ATC>ATT	p.I82I	HECTD3_uc009vxk.2_5'Flank|HECTD3_uc010olh.1_5'Flank|UROD_uc010oli.1_Missense_Mutation_p.H108Y|UROD_uc001cnb.1_Silent_p.I47I|UROD_uc010olj.1_Intron|UROD_uc001cnc.1_5'UTR	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	82						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					ATGCTGCCATCATTTTCTCCG	0.483									Porphyria_Cutanea_Tarda_Type_II				37	130					0	0	0	0	T	45478996	T	T	45478996	2	4	126	1	0	0	0	0	0	0	0	1	17097	816	29	2		2	UROD	1	45478996	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	1841834	45478996	203771625	5	22340											
KTI12	112970	broad.mit.edu	37	chr1	52499004	52499004	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctgcccgccgcctgggCtctcccgtcctcctcagcgc	1	8	11	21	4	2	0	1	0	1	0	5	0	4	0	6	1	3	3	6	1	0	0			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:52499004C>T	uc001ctj.1	-	1	469	c.430G>A	c.(430-432)GCC>ACC	p.A144T	TXNDC12_uc001cti.2_Intron	NM_138417	NP_612426	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated	144							ATP binding			central_nervous_system(2)	2						GCCGCCTGGGCTCTCCCGTCC	0.672													21	72					0	0	0	0	T	52499004	T	T	52499004	3	4	126	1	0	0	0	0	1	0	0	0	8624	797	28	4	638	4	KTI12	1	52499004	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	7020008	52499004	196751617	6	22341											
CLCA4	22802	broad.mit.edu	37	chr1	87012825	87012825	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggggttattcagaggttttgTtttcctcttagttctgtgcc	4	19	11	7	0	3	1	1	0	2	1	4	1	4	1	2	3	1	4	2	3	2	8			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:87012825T>C	uc009wcs.2	+	1	67	c.23T>C	c.(22-24)GTT>GCT	p.V8A	CLCA4_uc009wct.2_5'UTR|CLCA4_uc009wcu.2_5'UTR	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	8						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AGAGGTTTTGTTTTCCTCTTA	0.363													11	98					0	0	0	0	C	87012825	C	C	87012825	3	2	126	1	0	0	0	0	1	0	0	0	3474	1725	60	5	25	5	CLCA4	1	87012825	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08	34513821	87012825	162237796	7	22342											
CCDC76	54482	broad.mit.edu	37	chr1	100606565	100606565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctagtggaaaaggtgaccaCaagattcaaggtaagtgaaa	17	7	11	6	0	1	3	1	2	0	1	1	4	1	4	2	3	0	1	2	3	7	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:100606565C>T	uc001dsv.2	+	7	678	c.659C>T	c.(658-660)ACA>ATA	p.T220I	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Missense_Mutation_p.T220I	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	220					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		AAGGTGACCACAAGATTCAAG	0.348													6	41					0	0	0	0	T	100606565	T	T	100606565	3	4	126	1	0	0	0	0	1	0	0	0	2863	478	17	4	685	4	CCDC76	1	100606565	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	13593740	100606565	148644056	8	22343											
AKNAD1	254268	broad.mit.edu	37	chr1	109366241	109366241	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtaggaatcttagtgccaCagtcctgacatttgttactc	10	13	9	9	0	1	1	0	1	1	0	3	2	2	2	2	2	2	2	2	2	4	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:109366241C>T	uc001dwa.2	-	12	2275	c.2006G>A	c.(2005-2007)TGT>TAT	p.C669Y	AKNAD1_uc010ovb.1_Missense_Mutation_p.C376Y|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	669										ovary(3)	3						CTTAGTGCCACAGTCCTGACA	0.488													10	55					0	0	0	0	T	109366241	T	T	109366241	3	4	126	1	0	0	0	0	1	0	0	0	464	478	17	4	524	4	AKNAD1	1	109366241	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	8759676	109366241	139884380	9	22344											
DENND2D	79961	broad.mit.edu	37	chr1	111731345	111731345	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttaactcattgatcccctGaccaagagagtctaagatgt	12	12	7	10	0	2	4	1	2	1	2	3	5	3	4	3	0	1	0	3	0	3	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:111731345G>A	uc001eak.1	-	10	1278	c.1078C>T	c.(1078-1080)CAG>TAG	p.Q360*	DENND2D_uc001eal.1_Nonsense_Mutation_p.Q357*	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	360										ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		TTGATCCCCTGACCAAGAGAG	0.468													8	207					0	0	0	0	A	111731345	A	A	111731345	4	1	126	1	0	0	0	0	0	1	0	0	4453	1299	45	2	349	2	DENND2D	1	111731345	Nonsense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	2365104	111731345	137519276	10	22345											
HRNR	388697	broad.mit.edu	37	chr1	152187050	152187050	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccatgctgagtgtaaccaGaggactgccatgagctagac	12	8	11	10	0	0	4	0	2	0	2	1	5	1	5	3	1	4	3	3	1	2	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:152187050G>A	uc001ezt.1	-	3	7131	c.7055C>T	c.(7054-7056)TCT>TTT	p.S2352F		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2352	25.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGTAACCAGAGGACTGCCA	0.567													19	301					0	0	0	0	A	152187050	A	A	152187050	3	1	126	1	0	0	0	0	1	0	0	0	7398	942	33	2	1501	2	HRNR	1	152187050	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	40455705	152187050	97063571	11	22346											
PPP1R12B	4660	broad.mit.edu	37	chr1	202464747	202464747	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcctctaagaggctgtccatCcgagagaggaggcggcccaa	10	6	13	12	2	1	2	0	0	1	2	4	5	4	3	4	4	0	1	4	4	2	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:202464747C>T	uc001gya.1	+	17	2529	c.2385C>T	c.(2383-2385)ATC>ATT	p.I795I	PPP1R12B_uc001gxz.1_Silent_p.I795I|PPP1R12B_uc001gyb.1_Silent_p.I21I|PPP1R12B_uc001gyc.1_Silent_p.I21I	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	795					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GGCTGTCCATCCGAGAGAGGA	0.463													7	48					0	0	0	0	T	202464747	T	T	202464747	2	4	126	1	0	0	0	0	0	0	0	1	12415	845	30	2		2	PPP1R12B	1	202464747	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	50277697	202464747	46785874	12	22347											
USH2A	7399	broad.mit.edu	37	chr1	216017746	216017746	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagatagaatactcagtgaCaacaccatttgggtttgaag	15	11	9	6	0	1	4	1	2	0	2	1	4	1	4	1	1	2	1	1	1	6	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:216017746C>T	uc001hku.1	-	46	9535	c.9148G>A	c.(9148-9150)GTC>ATC	p.V3050I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3050	Fibronectin type-III 17.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TACTCAGTGACAACACCATTT	0.433										HNSCC(13;0.011)			7	61					0	0	0	0	T	216017746	T	T	216017746	3	4	126	1	0	0	0	0	1	0	0	0	17104	478	17	4	6568	4	USH2A	1	216017746	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	13552999	216017746	33232875	13	22348											
MIA3	375056	broad.mit.edu	37	chr1	222801790	222801790	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tagagagctctagttcagagGaagaaaaagaagatgatgat	18	8	12	3	0	2	7	1	2	1	5	2	9	2	8	0	1	1	2	0	1	6	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:222801790G>A	uc001hnl.2	+	4	1237	c.1228G>A	c.(1228-1230)GAA>AAA	p.E410K	MIA3_uc009xea.1_Missense_Mutation_p.E246K	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	410	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		TAGTTCAGAGGAAGAAAAAGA	0.408													15	61					0	0	0	0	A	222801790	A	A	222801790	3	1	126	1	0	0	0	0	1	0	0	0	9618	1175	41	2	1242	2	MIA3	1	222801790	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	6784044	222801790	26448831	14	22349											
LYST	1130	broad.mit.edu	37	chr1	235904814	235904814	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttctctcttgtgcagcgtGggctggcgacaaaatatgca	8	12	11	10	2	2	0	0	0	2	0	3	1	2	0	0	2	3	3	0	2	3	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:235904814G>A	uc001hxj.2	-	31	8441	c.8266C>T	c.(8266-8268)CAC>TAC	p.H2756Y	LYST_uc009xga.1_Missense_Mutation_p.H392Y	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2756					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGTGCAGCGTGGGCTGGCGAC	0.438									Chediak-Higashi_syndrome				11	77					0	0	0	0	A	235904814	A	A	235904814	3	1	126	1	0	0	0	0	1	0	0	0	9179	1348	47	4	3231	4	LYST	1	235904814	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	13103024	235904814	13345807	15	22350											
OR2L8	391190	broad.mit.edu	37	chr1	248112567	248112567	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cactatctcatccgcatgagCaaaagagtgtgtgtgctgat	11	11	10	9	1	1	3	1	2	1	1	3	3	2	3	1	0	2	3	1	0	3	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:248112567C>A	uc001idt.1	+	1	408	c.408C>A	c.(406-408)AGC>AGA	p.S136R	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TCCGCATGAGCAAAAGAGTGT	0.438													5	239					0.000602214	0.000622514	1	0	A	248112567	A	A	248112567	3	1	126	1	0	0	0	0	1	0	0	0	11063	709	25	4	410	4	OR2L8	1	248112567	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	12207753	248112567	1138054	16	22351											
OR2T6	254879	broad.mit.edu	37	chr1	248551586	248551586	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggattctcatcacagtgcAtcagatgacatcggctgaag	12	9	10	10	1	3	3	3	2	1	1	5	4	3	4	0	2	1	2	0	2	1	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:248551586A>C	uc001iei.1	+	1	677	c.677A>C	c.(676-678)CAT>CCT	p.H226P		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATCACAGTGCATCAGATGACA	0.502													24	85					0	0	0	0	C	248551586	C	C	248551586	3	2	126	1	0	0	0	0	1	0	0	0	11083	217	8	5	679	5	OR2T6	1	248551586	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08	439019	248551586	699035	17	22352											
OR2T11	127077	broad.mit.edu	37	chr1	248790265	248790265	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgactgagcagaaagtacatGggggtgtggaggcgagagtc	11	7	18	5	1	0	4	0	2	0	2	1	6	0	5	0	4	2	2	0	4	2	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:248790265G>A	uc001ier.1	-	1	165	c.165C>T	c.(163-165)CCC>CCT	p.P55P		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	55	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAAAGTACATGGGGGTGTGGA	0.468													6	69					0	0	0	0	A	248790265	A	A	248790265	2	1	126	1	0	0	0	0	0	0	0	1	11072	1335	47	4		4	OR2T11	1	248790265	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	238679	248790265	460356	18	22353											
MBOAT2	129642	broad.mit.edu	37	chr2	9008678	9008678	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcattattaatggcatcAgctatagaaaacaacattag	17	10	7	7	0	1	1	1	0	0	1	1	1	1	1	0	1	4	4	0	1	8	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:9008678A>G	uc002qzg.1	-	9	1018	c.885T>C	c.(883-885)GCT>GCC	p.A295A	MBOAT2_uc010yix.1_Silent_p.A295A	NM_138799	NP_620154	Q6ZWT7	MBOA2_HUMAN	O-acyltransferase (membrane bound) domain	295					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TAATGGCATCAGCTATAGAAA	0.333													3	96					0	0	0	0	G	9008678	G	G	9008678	2	3	126	1	0	0	0	0	0	0	0	1	9410	202	7	5		5	MBOAT2	2	9008678	Silent	SNP	A	TCGA-CR-6478-01A-11D-1870-08		9008678	234190695	19	22354											
OTOF	9381	broad.mit.edu	37	chr2	26750743	26750743	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttgaaaacctgaatctccaGcatctcatttctgtcgatgc	10	13	7	11	1	3	2	1	2	3	0	6	3	3	2	2	0	3	2	2	0	3	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:26750743G>C	uc002rhk.2	-	3	311	c.184C>G	c.(184-186)CTG>GTG	p.L62V		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	62	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGAATCTCCAGCATCTCATTT	0.577													11	79					0	0	0	0	C	26750743	C	C	26750743	3	2	126	1	0	0	0	0	1	0	0	0	11357	962	34	4	6314	4	OTOF	2	26750743	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	17742065	26750743	216448630	20	22355											
FAM98A	25940	broad.mit.edu	37	chr2	33810258	33810258	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccctccatctgtccagcctCcttgatgcttatttcctctt	4	17	4	16	0	2	1	0	1	2	0	7	1	7	1	6	0	2	1	6	0	1	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:33810258C>T	uc002rpa.1	-	8	1216	c.1142G>A	c.(1141-1143)GGA>GAA	p.G381E	FAM98A_uc010yne.1_Missense_Mutation_p.G186E|FAM98A_uc010ynd.1_Missense_Mutation_p.G212E|FAM98A_uc002roz.1_Missense_Mutation_p.G219E	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	382	Gly-rich.									ovary(1)	1	all_hematologic(175;0.115)					TGTCCAGCCTCCTTGATGCTT	0.577													6	97					0	0	0	0	T	33810258	T	T	33810258	3	4	126	1	0	0	0	0	1	0	0	0	5688	855	30	2	418	2	FAM98A	2	33810258	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	7059515	33810258	209389115	21	22356											
MAP4K3	8491	broad.mit.edu	37	chr2	39485697	39485697	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atggtatctctctccagttgGgttacatgagtaacatttgt	9	16	9	7	0	2	1	0	1	2	0	4	1	2	1	1	2	2	4	1	2	3	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:39485697G>A	uc002rro.2	-	30	2431	c.2340C>T	c.(2338-2340)ACC>ACT	p.T780T	MAP4K3_uc002rrp.2_Silent_p.T759T|MAP4K3_uc010yns.1_Silent_p.T333T	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	780	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TCTCCAGTTGGGTTACATGAG	0.328													7	40					0	0	0	0	A	39485697	A	A	39485697	2	1	126	1	0	0	0	0	0	0	0	1	9314	1219	43	4		4	MAP4K3	2	39485697	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	5675439	39485697	203713676	22	22357											
TTC7A	57217	broad.mit.edu	37	chr2	47300993	47300993	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaggctgccgttgactgcttCctcaccgcccttgagctgga	5	10	12	14	2	1	2	1	2	0	0	2	4	2	3	4	2	3	4	4	2	0	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:47300993C>T	uc002rvo.2	+	20	2876	c.2508C>T	c.(2506-2508)TTC>TTT	p.F836F	TTC7A_uc002rvm.2_Silent_p.F802F|TTC7A_uc010fbb.2_Silent_p.F860F|TTC7A_uc010fbc.2_Silent_p.F482F|TTC7A_uc002rvp.2_Silent_p.F717F|C2orf61_uc010fbd.2_Intron|TTC7A_uc002rvq.2_Silent_p.F576F|TTC7A_uc002rvr.2_Silent_p.F285F	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	836	TPR 9.						binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TTGACTGCTTCCTCACCGCCC	0.677													10	24					0	0	0	0	T	47300993	T	T	47300993	2	4	126	1	0	0	0	0	0	0	0	1	16780	854	30	2		2	TTC7A	2	47300993	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	7815296	47300993	195898380	23	22358											
NRXN1	9378	broad.mit.edu	37	chr2	50280535	50280535	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggctgttgactcagttgtCatagaggaaggcacttcacc	9	11	12	9	0	3	2	3	1	0	1	3	3	3	3	1	3	0	4	1	3	2	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:50280535C>T	uc010fbp.2	-	4	1614	c.807G>A	c.(805-807)ATG>ATA	p.M269I	NRXN1_uc002rxb.3_Missense_Mutation_p.M1006I|NRXN1_uc010fbq.2_Missense_Mutation_p.M1374I|NRXN1_uc002rxe.3_Missense_Mutation_p.M1304I	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	269	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACTCAGTTGTCATAGAGGAAG	0.483													11	102					0	0	0	0	T	50280535	T	T	50280535	3	4	126	1	0	0	0	0	1	0	0	0	10719	826	29	2	533	2	NRXN1	2	50280535	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	2979542	50280535	192918838	24	22359											
BMP10	27302	broad.mit.edu	37	chr2	69092867	69092867	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gatgggctctagctttgtggGcacacagcaggctttggaag	8	10	15	8	0	1	0	0	0	1	0	1	2	1	1	0	4	2	5	0	4	2	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:69092867G>A	uc002sez.1	-	2	1330	c.1171C>T	c.(1171-1173)CCC>TCC	p.P391S		NM_014482	NP_055297	O95393	BMP10_HUMAN	bone morphogenetic protein 10 preproprotein	391					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			ovary(2)	2						AGCTTTGTGGGCACACAGCAG	0.512													4	153					0	0	0	0	A	69092867	A	A	69092867	3	1	126	1	0	0	0	0	1	0	0	0	1460	1203	42	4	107	4	BMP10	2	69092867	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	18812332	69092867	174106506	25	22360											
ANKRD36	375248	broad.mit.edu	37	chr2	97866192	97866192	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcaaattccattcaggcCacaagtgatgagaaggattc	13	11	9	8	0	2	2	2	2	0	1	4	4	3	3	2	2	0	1	2	2	3	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:97866192C>T	uc010yva.1	+	46	3031	c.2787C>T	c.(2785-2787)GCC>GCT	p.A929A	ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	929											0						CCATTCAGGCCACAAGTGATG	0.333													4	36					0	0	0	0	T	97866192	T	T	97866192	2	4	126	1	0	0	0	0	0	0	0	1	665	581	21	4		4	ANKRD36	2	97866192	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	28773325	97866192	145333181	26	22361											
ACTR1B	10120	broad.mit.edu	37	chr2	98275416	98275416	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaacacctctgccgccttCtcccggttcttactcgggtt	6	12	8	15	3	3	1	0	0	3	1	5	1	3	1	4	2	3	2	4	2	3	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:98275416C>T	uc002syb.2	-	5	574	c.366G>A	c.(364-366)GAG>GAA	p.E122E		NM_005735	NP_005726	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B,	122						centrosome|dynactin complex	ATP binding|protein binding			skin(1)	1						CTGCCGCCTTCTCCCGGTTCT	0.607													25	348					0	0	0	0	T	98275416	T	T	98275416	2	4	126	1	0	0	0	0	0	0	0	1	210	912	32	2		2	ACTR1B	2	98275416	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	409224	98275416	144923957	27	22362											
ANAPC1	64682	broad.mit.edu	37	chr2	112608479	112608479	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagtccaggaataaaaacCtttcccacctttaagcaata	15	9	6	11	0	0	0	0	0	0	0	2	1	2	1	4	2	2	2	4	2	7	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:112608479C>A	uc002thi.2	-	14	1771	c.1524G>T	c.(1522-1524)AAG>AAT	p.K508N		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	508					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						GAATAAAAACCTTTCCCACCT	0.378													4	20					5.9392e-07	6.35356e-07	1	0	A	112608479	A	A	112608479	3	1	126	1	0	0	0	0	1	0	0	0	598	680	24	4	4450	4	ANAPC1	2	112608479	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	14333063	112608479	130590894	28	22363											
YSK4	80122	broad.mit.edu	37	chr2	135744631	135744631	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttaggtttctgagtccggTgagttgattgcttctttgct	4	20	11	6	1	2	3	0	3	2	0	3	3	3	3	1	2	2	4	1	2	1	7			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:135744631T>A	uc002tue.1	-	7	1842	c.1811A>T	c.(1810-1812)CAC>CTC	p.H604L	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.H491L|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.H332L|YSK4_uc002tui.3_Missense_Mutation_p.H621L	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	604							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTGAGTCCGGTGAGTTGATTG	0.453													28	132					0	0	0	0	A	135744631	A	A	135744631	3	1	126	1	0	0	0	0	1	0	0	0	17563	1696	59	5	2191	5	YSK4	2	135744631	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08	23136152	135744631	107454742	29	22364											
MARCH7	64844	broad.mit.edu	37	chr2	160599714	160599714	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaactttcctgtacaaactGtactacctcagctgggagaa	13	11	7	10	0	1	1	1	0	0	1	2	2	2	1	2	1	6	3	2	1	7	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:160599714G>A	uc002uax.2	+	3	418	c.296G>A	c.(295-297)TGT>TAT	p.C99Y	MARCH7_uc010foq.2_Missense_Mutation_p.C99Y|MARCH7_uc010zcn.1_Missense_Mutation_p.C99Y|MARCH7_uc010for.2_Missense_Mutation_p.C61Y	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	99	Ser-rich.						ligase activity|zinc ion binding				0						TGTACAAACTGTACTACCTCA	0.403													10	56					0	0	0	0	A	160599714	A	A	160599714	3	1	126	1	0	0	0	0	1	0	0	0	9359	1377	48	4	302	4	MARCH7	2	160599714	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	24855083	160599714	82599659	30	22365											
SCN9A	6335	broad.mit.edu	37	chr2	167133711	167133711	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtagctcttaccaaagagctGcatgccgaccacagcaaaaa	15	6	8	12	1	1	1	0	0	1	1	1	2	1	1	3	0	6	5	3	0	5	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:167133711G>T	uc010fpl.2	-	16	2964	c.2623C>A	c.(2623-2625)CAG>AAG	p.Q875K	uc002udp.2_RNA	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	886	II.|Helical; Name=S5 of repeat II; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CCAAAGAGCTGCATGCCGACC	0.468													11	115					5.01169e-05	5.2395e-05	1	0	T	167133711	T	T	167133711	3	4	126	1	0	0	0	0	1	0	0	0	13990	1328	46	4	3358	4	SCN9A	2	167133711	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	6533997	167133711	76065662	31	22366											
AOX1	316	broad.mit.edu	37	chr2	201507512	201507512	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttgcagccaaatgtggactAtcccctgagaaggtaatact	12	10	10	9	0	0	1	0	1	0	1	1	3	1	2	3	2	3	3	3	2	5	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:201507512A>G	uc002uvx.2	+	25	2936	c.2835A>G	c.(2833-2835)CTA>CTG	p.L945L	AOX1_uc010zhf.1_Silent_p.L501L|AOX1_uc010fsu.2_Silent_p.L311L	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	945					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	AATGTGGACTATCCCCTGAGA	0.343													9	59					0	0	0	0	G	201507512	G	G	201507512	2	3	126	1	0	0	0	0	0	0	0	1	729	436	16	5		5	AOX1	2	201507512	Silent	SNP	A	TCGA-CR-6478-01A-11D-1870-08	34373801	201507512	41691861	32	22367											
ZNF501	115560	broad.mit.edu	37	chr3	44776296	44776296	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattaaacaccagcgaattcAtactggagagaaaccatata	18	9	6	8	1	1	1	1	0	0	1	1	4	1	2	2	1	4	0	2	1	8	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:44776296A>G	uc003cnu.1	+	3	784	c.383A>G	c.(382-384)CAT>CGT	p.H128R	ZNF501_uc003cnv.1_Missense_Mutation_p.H128R	NM_145044	NP_659481	Q96CX3	ZN501_HUMAN	zinc finger protein 501	128	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		CAGCGAATTCATACTGGAGAG	0.408													18	33					0	0	0	0	G	44776296	G	G	44776296	3	3	126	1	0	0	0	0	1	0	0	0	18016	217	8	5	385	5	ZNF501	3	44776296	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08		44776296	153246134	33	22368											
BSN	8927	broad.mit.edu	37	chr3	49689519	49689519	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgactgatgaggatttcatgCgacggcagattctcgagatg	10	11	13	7	3	2	5	1	3	1	2	3	8	2	6	0	2	1	1	0	2	0	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:49689519C>T	uc003cxe.3	+	5	2644	c.2530C>T	c.(2530-2532)CGA>TGA	p.R844*		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	844					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGATTTCATGCGACGGCAGAT	0.622													12	24					0	0	0	0	T	49689519	T	T	49689519	4	4	126	1	0	0	0	0	0	1	0	0	1535	760	27	1	2548	1	BSN	3	49689519	Nonsense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	4913223	49689519	148332911	34	22369											
DCP1A	55802	broad.mit.edu	37	chr3	53381537	53381537	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcccagctcgactcagcGcctccatcttgaatcccaga	8	8	7	18	2	2	2	1	1	1	1	5	3	4	2	5	0	3	1	5	0	1	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:53381537G>A	uc003dgs.3	-	1	101	c.8C>T	c.(7-9)GCG>GTG	p.A3V	DCP1A_uc003dgt.3_RNA	NM_018403	NP_060873	Q9NPI6	DCP1A_HUMAN	DCP1 decapping enzyme homolog A	3					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		TCGACTCAGCGCCTCCATCTT	0.622													7	44					0	0	0	0	A	53381537	A	A	53381537	3	1	126	1	0	0	0	0	1	0	0	0	4315	1087	38	1	1780	1	DCP1A	3	53381537	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	3692018	53381537	144640893	35	22370											
POLQ	10721	broad.mit.edu	37	chr3	121206399	121206399	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaatagggctgttgtctttGaacccatttctactccctgg	7	15	8	11	0	2	1	0	1	2	0	3	1	3	1	2	2	2	2	2	2	4	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:121206399G>A	uc003eee.3	-	16	5508	c.5379C>T	c.(5377-5379)TTC>TTT	p.F1793F	POLQ_uc003eed.2_Silent_p.F965F	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1793					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TGTTGTCTTTGAACCCATTTC	0.378								DNA_polymerases_(catalytic_subunits)					8	107					0	0	0	0	A	121206399	A	A	121206399	2	1	126	1	0	0	0	0	0	0	0	1	12263	1281	45	2		2	POLQ	3	121206399	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	67824862	121206399	76816031	36	22371											
GOLGB1	2804	broad.mit.edu	37	chr3	121410866	121410866	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttttgatggttttcagtgTttccataagctgattggttt	6	21	9	5	0	1	2	1	2	0	0	2	2	2	2	1	2	1	4	1	2	1	8			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:121410866T>C	uc003eei.3	-	14	7456	c.7330A>G	c.(7330-7332)ACA>GCA	p.T2444A	GOLGB1_uc010hrc.2_Missense_Mutation_p.T2449A|GOLGB1_uc003eej.3_Missense_Mutation_p.T2410A	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2444	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		GTTTTCAGTGTTTCCATAAGC	0.393													21	128					0	0	0	0	C	121410866	C	C	121410866	3	2	126	1	0	0	0	0	1	0	0	0	6602	1725	60	5	2485	5	GOLGB1	3	121410866	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08	204467	121410866	76611564	37	22372											
TFDP2	7029	broad.mit.edu	37	chr3	141692899	141692899	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcacttacctccagattCtgacattcctgagcagaatt	10	14	5	12	0	2	4	1	2	2	2	5	4	4	4	3	0	2	1	3	0	2	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:141692899C>T	uc003eun.3	-	8	1033	c.654G>A	c.(652-654)CAG>CAA	p.Q218Q	TFDP2_uc003euk.3_Silent_p.Q131Q|TFDP2_uc010hur.2_Silent_p.Q158Q|TFDP2_uc003eul.3_Silent_p.Q158Q|TFDP2_uc011bnf.1_Silent_p.Q121Q|TFDP2_uc011bng.1_Silent_p.Q82Q|TFDP2_uc003eum.3_Silent_p.Q158Q	NM_006286	NP_006277	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization	218					cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)	1						CCTCCAGATTCTGACATTCCT	0.294													31	82					0	0	0	0	T	141692899	T	T	141692899	2	4	126	1	0	0	0	0	0	0	0	1	15864	912	32	2		2	TFDP2	3	141692899	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	20282033	141692899	56329531	38	22373											
LRPAP1	4043	broad.mit.edu	37	chr4	3520617	3520617	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttcggtcctgctcagggtCtccagcaggacgttgtactc	5	11	11	14	2	2	0	1	0	1	0	6	1	3	1	3	3	3	4	3	3	1	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:3520617C>T	uc003ghi.2	-	4	658	c.573G>A	c.(571-573)GAG>GAA	p.E191E		NM_002337	NP_002328	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein	191					negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		TGCTCAGGGTCTCCAGCAGGA	0.393													3	9					0	0	0	0	T	3520617	T	T	3520617	2	4	126	1	0	0	0	0	0	0	0	1	9014	912	32	2		2	LRPAP1	4	3520617	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08		3520617	187633659	39	22374											
ARAP2	116984	broad.mit.edu	37	chr4	36162102	36162102	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttatttaattcttctttggtGagagatgccaaaagagtttt	11	18	8	4	0	2	3	0	1	2	2	2	4	2	3	1	1	1	1	1	1	4	8			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:36162102G>A	uc003gsq.1	-	13	2759	c.2421C>T	c.(2419-2421)CTC>CTT	p.L807L	ARAP2_uc003gsr.1_Silent_p.L807L	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	807	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTTCTTTGGTGAGAGATGCCA	0.289													3	36					0	0	0	0	A	36162102	A	A	36162102	2	1	126	1	0	0	0	0	0	0	0	1	839	1277	45	2		2	ARAP2	4	36162102	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	32641485	36162102	154992174	40	22375											
SLC30A9	10463	broad.mit.edu	37	chr4	42069198	42069198	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccacttgcatgggccttaCttctataacaggtaaatatt	12	13	7	9	0	1	0	0	0	1	0	1	0	1	0	2	2	4	2	2	2	6	8			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:42069198C>T	uc003gwl.2	+	14	1387	c.1241C>T	c.(1240-1242)ACT>ATT	p.T414I	SLC30A9_uc011byx.1_Missense_Mutation_p.T174I	NM_006345	NP_006336	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter),	414					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3						ATGGGCCTTACTTCTATAACA	0.333													5	146					0	0	0	0	T	42069198	T	T	42069198	3	4	126	1	0	0	0	0	1	0	0	0	14626	565	20	4	1295	4	SLC30A9	4	42069198	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	5907096	42069198	149085078	41	22376											
LRRC66	339977	broad.mit.edu	37	chr4	52861043	52861044	+	Missense_Mutation	DNP	GG	AA	AA																															cttgcactctctgaacttatGgagctcagagtgaacagaga																										TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:52861043_52861044GG>AA	uc003gzi.2	-	4	2157_2158	c.2144_2145CC>TT	c.(2143-2145)TCC>TTT	p.S715F		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	715						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CTGAACTTATGGAGCTCAGAGT	0.53													5	86					0	0	0	0	AA	52861044	AA	AA	52861043	3	1	126	1	0	0	0	0	1	0	0	0	9068	1335	47	4	501	4	LRRC66	4	52861043	Missense_Mutation	DNP	GG	TCGA-CR-6478-01A-11D-1870-08	10791845	52861043	138293233	42	22377											
EPHA5	2044	broad.mit.edu	37	chr4	66197747	66197747	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatccattttccatgaaaatCtctgtataccggcccatctt	10	15	4	12	1	2	1	0	1	2	0	5	1	4	1	4	1	1	1	4	1	5	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:66197747C>T	uc003hcy.2	-	17	3145	c.2952G>A	c.(2950-2952)GAG>GAA	p.E984E	EPHA5_uc003hcx.2_Silent_p.E916E|EPHA5_uc003hcz.2_Silent_p.E962E|EPHA5_uc011cah.1_Silent_p.E985E|EPHA5_uc011cai.1_Silent_p.E963E|EPHA5_uc003hda.2_Silent_p.E985E	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	984	Cytoplasmic (Potential).|SAM.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CCATGAAAATCTCTGTATACC	0.433										TSP Lung(17;0.13)			11	43					0	0	0	0	T	66197747	T	T	66197747	2	4	126	1	0	0	0	0	0	0	0	1	5194	912	32	2		2	EPHA5	4	66197747	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	13336704	66197747	124956529	43	22378											
CXCL10	3627	broad.mit.edu	37	chr4	76943923	76943923	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttggattaacaggttgatTactaatgctgatgcaggtac	11	13	10	7	0	0	2	0	2	0	0	0	3	0	3	1	3	5	4	1	3	4	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:76943923T>G	uc003hjl.3	-	2	179	c.109A>C	c.(109-111)AAT>CAT	p.N37H	ART3_uc003hji.2_Intron|ART3_uc003hjj.2_Intron|ART3_uc003hjk.2_Intron	NM_001565	NP_001556	P02778	CXL10_HUMAN	small inducible cytokine B10 precursor	37					blood circulation|cell surface receptor linked signaling pathway|cell-cell signaling|chemotaxis|inflammatory response|muscle organ development|positive regulation of cell proliferation	extracellular space	cAMP-dependent protein kinase regulator activity|chemokine activity				0			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ACAGGTTGATTACTAATGCTG	0.408													4	81					0	0	0	0	G	76943923	G	G	76943923	3	3	126	1	0	0	0	0	1	0	0	0	4095	1754	61	5	199	5	CXCL10	4	76943923	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08	10746176	76943923	114210353	44	22379											
SEC31A	22872	broad.mit.edu	37	chr4	83774850	83774850	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggctatctccttcattttcaAgcctggttcccaaaagatct	9	14	6	12	0	4	1	2	0	2	1	6	1	5	1	3	2	1	2	3	2	4	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:83774850A>G	uc003hnf.2	-	18	2191	c.2027T>C	c.(2026-2028)CTT>CCT	p.L676P	SEC31A_uc003hne.2_Missense_Mutation_p.L409P|SEC31A_uc011ccl.1_Missense_Mutation_p.L637P|SEC31A_uc003hnl.2_Missense_Mutation_p.L637P|SEC31A_uc003hng.2_Missense_Mutation_p.L676P|SEC31A_uc003hnh.2_Missense_Mutation_p.L676P|SEC31A_uc003hni.2_Missense_Mutation_p.L676P|SEC31A_uc003hnj.2_Missense_Mutation_p.L637P|SEC31A_uc011ccm.1_Missense_Mutation_p.L671P|SEC31A_uc011ccn.1_Missense_Mutation_p.L676P|SEC31A_uc003hnk.2_Missense_Mutation_p.L637P|SEC31A_uc003hnm.2_Missense_Mutation_p.L676P|SEC31A_uc003hnn.1_Missense_Mutation_p.L676P	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	676	WD 7.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				TTCATTTTCAAGCCTGGTTCC	0.378													14	40					0	0	0	0	G	83774850	G	G	83774850	3	3	126	1	0	0	0	0	1	0	0	0	14063	72	3	5	1675	5	SEC31A	4	83774850	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08	6830927	83774850	107379426	45	22380											
THAP9	79725	broad.mit.edu	37	chr4	83839313	83839313	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagatacaaatttcaagatGaagtttttctaagcaaagta	17	12	6	6	0	2	3	1	1	1	2	2	3	2	3	1	0	2	3	1	0	7	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:83839313G>A	uc003hnt.2	+	5	2067	c.1948G>A	c.(1948-1950)GAA>AAA	p.E650K	THAP9_uc003hns.1_Missense_Mutation_p.E506K|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_Missense_Mutation_p.E367K	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	650							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				ATTTCAAGATGAAGTTTTTCT	0.398													6	50					0	0	0	0	A	83839313	A	A	83839313	3	1	126	1	0	0	0	0	1	0	0	0	15917	1291	45	2	1966	2	THAP9	4	83839313	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	64463	83839313	107314963	46	22381											
COPS4	51138	broad.mit.edu	37	chr4	83989672	83989672	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgatggaatagttcattttGaaagtaagaggttttgtgta	12	17	11	1	0	1	3	1	2	0	1	1	4	1	4	0	2	0	4	0	2	5	9			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:83989672G>A	uc003hoa.2	+	9	1223	c.1084G>A	c.(1084-1086)GAA>AAA	p.E362K	COPS4_uc003hob.2_Missense_Mutation_p.E362K|COPS4_uc010ijw.2_Missense_Mutation_p.E394K|COPS4_uc010ijx.2_Intron	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	362	PCI.				cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				AGTTCATTTTGAAAGTAAGAG	0.333													5	44					0	0	0	0	A	83989672	A	A	83989672	3	1	126	1	0	0	0	0	1	0	0	0	3750	1291	45	2	1118	2	COPS4	4	83989672	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	150359	83989672	107164604	47	22382											
TET2	54790	broad.mit.edu	37	chr4	106156428	106156428	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccccaaccaaagtaacacAacacttttaagggaagtgaa	18	7	6	10	0	0	1	0	1	0	0	0	2	0	2	3	1	4	1	3	1	8	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:106156428A>G	uc003hxk.2	+	3	1715	c.1329A>G	c.(1327-1329)ACA>ACG	p.T443T	TET2_uc011cez.1_Silent_p.T464T|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Silent_p.T443T|TET2_uc003hxi.1_Silent_p.T443T	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	443					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		AAAGTAACACAACACTTTTAA	0.463			Mis N|F		MDS								22	45					0	0	0	0	G	106156428	G	G	106156428	2	3	126	1	0	0	0	0	0	0	0	1	15836	117	5	5		5	TET2	4	106156428	Silent	SNP	A	TCGA-CR-6478-01A-11D-1870-08	22166756	106156428	84997848	48	22383											
KIAA0947	23379	broad.mit.edu	37	chr5	5461426	5461426	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtaatgatacagatattaCtactaaagtattctctactg	14	15	6	6	0	1	2	0	1	1	1	2	2	1	2	0	1	4	2	0	1	9	9			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:5461426C>A	uc003jdm.3	+	13	2201	c.1979C>A	c.(1978-1980)ACT>AAT	p.T660N		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	660										ovary(1)|central_nervous_system(1)	2						ACAGATATTACTACTAAAGTA	0.393													16	62					4.7546e-09	5.17661e-09	1	0	A	5461426	A	A	5461426	3	1	126	1	0	0	0	0	1	0	0	0	8241	565	20	4	2029	4	KIAA0947	5	5461426	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08		5461426	175453834	49	22384											
RNASEN	29102	broad.mit.edu	37	chr5	31409214	31409214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgtcctaagtgtcaagcaaCactgctgaagctgggatttg	10	11	11	9	0	1	1	1	1	0	0	2	2	2	2	1	1	4	3	1	1	4	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:31409214C>T	uc003jhg.2	-	32	4162	c.3803G>A	c.(3802-3804)TGT>TAT	p.C1268Y	RNASEN_uc003jhh.2_Missense_Mutation_p.C1231Y	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	1268	Necessary for interaction with DGCR8 and pri-miRNA processing activity.|DRBM.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						TGTCAAGCAACACTGCTGAAG	0.453													8	51					0	0	0	0	T	31409214	T	T	31409214	3	4	126	1	0	0	0	0	1	0	0	0	13482	478	17	4	337	4	RNASEN	5	31409214	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	25947788	31409214	149506046	50	22385											
ZFR	51663	broad.mit.edu	37	chr5	32407005	32407025	+	In_Frame_Del	DEL	GGCAGCTGTTGCAGCAGCAGC	-	-																															gtaaaggtggtccctgtccaGgcagctgttgcagcagcagc																										TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:32407005_32407025delGGCAGCTGTTGCAGCAGCAGC	uc003jhr.1	-	6	966_986	c.886_906delGCTGCTGCTGCAACAGCTGCC	c.(886-906)GCTGCTGCTGCAACAGCTGCCdel	p.AAAATAA296del	ZFR_uc010iun.1_In_Frame_Del_p.AAAATAA296del	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	296_302	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		TCCCTGTCCAGGCAgctgttgcagcagcagcagcagctgct	0.294													---	---	---								-	32407025	-	-	32407005	7	5	126	1	0	1	0	1	0	0	0	0	17726	987	35	0	2378	0	ZFR	5	32407005	In_Frame_Del	DEL	GGCAGCTGTTGCAGCAGCAGC	TCGA-CR-6478-01A-11D-1870-08	997791	32407005	148508255	51	22386											
SEMA6A	57556	broad.mit.edu	37	chr5	115782989	115782989	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggctgggggaggcccgcaGgggcaggtccgtgggaatca	6	5	21	9	2	1	0	1	0	0	0	2	2	2	2	2	8	0	3	2	8	1	0			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:115782989G>A	uc010jck.2	-	19	3122	c.2413C>T	c.(2413-2415)CTG>TTG	p.L805L	SEMA6A_uc003krx.3_Silent_p.L822L|SEMA6A_uc011cwe.1_Silent_p.L184L|SEMA6A_uc003krv.3_Silent_p.L232L|SEMA6A_uc003krw.3_Silent_p.L282L|SEMA6A_uc010jcj.2_Silent_p.L349L	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	805	Cytoplasmic (Potential).|Pro-rich.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		GAGGCCCGCAGGGGCAGGTCC	0.652													7	50					0	0	0	0	A	115782989	A	A	115782989	2	1	126	1	0	0	0	0	0	0	0	1	14104	991	35	4		4	SEMA6A	5	115782989	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	83375984	115782989	65132271	52	22387											
HSD17B4	3295	broad.mit.edu	37	chr5	118865640	118865640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgcatatgtggatcttgcaCcaacatctggtacttcagct	10	13	8	10	0	3	0	1	0	2	0	3	1	3	1	1	2	5	4	1	2	3	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:118865640C>T	uc003ksj.2	+	21	1942	c.1819C>T	c.(1819-1821)CCA>TCA	p.P607S	HSD17B4_uc011cwg.1_Missense_Mutation_p.P583S|HSD17B4_uc011cwh.1_Missense_Mutation_p.P589S|HSD17B4_uc011cwi.1_Missense_Mutation_p.P632S|HSD17B4_uc003ksk.3_Missense_Mutation_p.P460S|HSD17B4_uc011cwj.1_Missense_Mutation_p.P460S|HSD17B4_uc010jcn.1_Missense_Mutation_p.P345S|HSD17B4_uc010jco.1_Silent_p.H75H	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	607	Enoyl-CoA hydratase 2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	GGATCTTGCACCAACATCTGG	0.363													7	70					0	0	0	0	T	118865640	T	T	118865640	3	4	126	1	0	0	0	0	1	0	0	0	7425	507	18	4	1901	4	HSD17B4	5	118865640	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	3082651	118865640	62049620	53	22388											
PCDHA4	56144	broad.mit.edu	37	chr5	140188443	140188443	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaggtgttcgtgctggaCgaaaacgacaacgcgccagc	10	6	13	12	5	0	0	0	0	0	0	1	3	0	1	1	2	5	3	1	2	3	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:140188443C>T	uc003lhi.2	+	1	1772	c.1671C>T	c.(1669-1671)GAC>GAT	p.D557D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.D557D|PCDHA4_uc011daa.1_Silent_p.D557D	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	557	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGTGCTGGACGAAAACGACA	0.667													7	50					0	0	0	0	T	140188443	T	T	140188443	2	4	126	1	0	0	0	0	0	0	0	1	11580	535	19	1		1	PCDHA4	5	140188443	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	21322803	140188443	40726817	54	22389											
HIST1H2BB	3018	broad.mit.edu	37	chr6	26043662	26043662	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcgagaagcctcgcccGcgatgcgctcgaagatgtcg	8	5	14	14	7	0	2	0	0	0	2	3	5	0	2	3	1	2	1	3	1	2	0			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:26043662G>A	uc003nfu.2	-	1	224	c.224C>T	c.(223-225)GCG>GTG	p.A75V	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	75					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGCCTCGCCCGCGATGCGCTC	0.597													36	89					0	0	0	0	A	26043662	A	A	26043662	3	1	126	1	0	0	0	0	1	0	0	0	7180	1087	38	1	160	1	HIST1H2BB	6	26043662	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08		26043662	145071405	55	22390											
HIST1H2AG	8969	broad.mit.edu	37	chr6	27101060	27101060	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggaactggcgggcaacgcGgcccgcgacaacaagaagac	12	2	14	13	5	0	2	0	0	0	2	0	4	0	3	1	4	3	1	1	4	5	0			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:27101060G>A	uc003niw.2	+	1	244	c.210G>A	c.(208-210)GCG>GCA	p.A70A	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	70					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						CGGGCAACGCGGCCCGCGACA	0.647													28	52					0	0	0	0	A	27101060	A	A	27101060	2	1	126	1	0	0	0	0	0	0	0	1	7172	1103	39	1		1	HIST1H2AG	6	27101060	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	1057398	27101060	144014007	56	22391											
OR2J2	26707	broad.mit.edu	37	chr6	29141562	29141562	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttcatcatcatcctgtcAtacgtggactcccatctcca	8	13	5	15	1	5	0	4	0	1	0	8	1	7	1	3	1	1	1	3	1	1	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:29141562A>T	uc011dlm.1	+	1	252	c.150A>T	c.(148-150)TCA>TCT	p.S50S		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	50	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCATCCTGTCATACGTGGACT	0.453													6	288					0	0	0	0	T	29141562	T	T	29141562	2	4	126	1	0	0	0	0	0	0	0	1	11057	204	8	5		5	OR2J2	6	29141562	Silent	SNP	A	TCGA-CR-6478-01A-11D-1870-08	2040502	29141562	141973505	57	22392											
DNAH8	1769	broad.mit.edu	37	chr6	38939413	38939413	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggacaagaagtacatgctcGaaagctgattcagatgtcaa	16	8	10	7	1	2	3	2	1	0	2	3	5	2	4	0	1	3	3	0	1	5	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:38939413G>A	uc003ooe.1	+	81	12446	c.11846G>A	c.(11845-11847)CGA>CAA	p.R3949Q	DNAH8_uc003oog.1_Missense_Mutation_p.R398Q	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GTACATGCTCGAAAGCTGATT	0.413													4	31					0	0	0	0	A	38939413	A	A	38939413	3	1	126	1	0	0	0	0	1	0	0	0	4629	1058	37	1	12160	1	DNAH8	6	38939413	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	9797851	38939413	132175654	58	22393											
HSP90AB1	3326	broad.mit.edu	37	chr6	44219502	44219502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacgaagactccactaaccGccgccgcctgtctgagctgc	8	6	9	18	4	1	2	0	1	1	1	2	3	2	2	6	0	3	1	6	0	2	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:44219502G>A	uc003oxa.1	+	9	1427	c.1343G>A	c.(1342-1344)CGC>CAC	p.R448H	HSP90AB1_uc011dvr.1_Missense_Mutation_p.R438H|HSP90AB1_uc003oxb.1_Missense_Mutation_p.R448H|HSP90AB1_uc011dvs.1_Missense_Mutation_p.R268H|HSP90AB1_uc003oxc.1_Missense_Mutation_p.R86H	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	448					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCCACTAACCGCCGCCGCCTG	0.468													10	103					0	0	0	0	A	44219502	A	A	44219502	3	1	126	1	0	0	0	0	1	0	0	0	7441	1087	38	1	1373	1	HSP90AB1	6	44219502	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	5280089	44219502	126895565	59	22394											
GSTA5	221357	broad.mit.edu	37	chr6	52701052	52701052	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagggctctctccttcatgTctttcccataaaggttgtat	8	15	7	11	0	3	0	1	0	2	0	6	0	5	0	2	2	0	3	2	2	3	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:52701052T>C	uc003pba.1	-	4	324	c.254A>G	c.(253-255)GAC>GGC	p.D85G		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	85	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	CTCCTTCATGTCTTTCCCATA	0.453													53	122					0	0	0	0	C	52701052	C	C	52701052	3	2	126	1	0	0	0	0	1	0	0	0	6873	1667	58	5	430	5	GSTA5	6	52701052	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08	8481550	52701052	118414015	60	22395											
FHL5	9457	broad.mit.edu	37	chr6	97052644	97052644	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatctttgttacaaagacCggcactggcatgaaggatgc	12	9	12	8	1	1	2	0	1	1	1	1	4	1	4	1	4	2	3	1	4	3	2	rs145856574	byFrequency	TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:97052644C>T	uc003pos.1	+	4	583	c.178C>T	c.(178-180)CGG>TGG	p.R60W	FHL5_uc003pot.1_Missense_Mutation_p.R60W	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	60	LIM zinc-binding 1.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TTACAAAGACCGGCACTGGCA	0.433													10	56					0	0	0	0	T	97052644	T	T	97052644	3	4	126	1	0	0	0	0	1	0	0	0	5913	643	23	1	184	1	FHL5	6	97052644	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	44351592	97052644	74062423	61	22396											
KLHL32	114792	broad.mit.edu	37	chr6	97414959	97414959	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgtctgaacgctgcctcaGgtatgccctgtaggatatgt	7	11	12	11	2	2	1	1	1	1	0	2	2	2	2	3	2	3	3	3	2	4	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:97414959G>C	uc010kcm.1	+	2	495	c.23G>C	c.(22-24)AGT>ACT	p.S8T	KLHL32_uc003poy.2_Missense_Mutation_p.S8T|KLHL32_uc011ead.1_Missense_Mutation_p.S8T|KLHL32_uc003poz.2_5'UTR|KLHL32_uc011eae.1_Missense_Mutation_p.S8T	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	8										ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		CGCTGCCTCAGGTATGCCCTG	0.483													5	12					0	0	0	0	C	97414959	C	C	97414959	3	2	126	1	0	0	0	0	1	0	0	0	8425	1014	35	4	25	4	KLHL32	6	97414959	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	362315	97414959	73700108	62	22397											
C6orf211	79624	broad.mit.edu	37	chr6	151785628	151785628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtatttaaagaatcaaaaGagcaaaatttctatgggtca	18	12	7	4	0	3	2	2	0	1	2	3	2	3	2	0	1	1	2	0	1	9	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:151785628G>A	uc003qok.1	+	4	692	c.433G>A	c.(433-435)GAG>AAG	p.E145K	C6orf211_uc011ees.1_Missense_Mutation_p.E26K	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	145							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		AGAATCAAAAGAGCAAAATTT	0.328													6	37					0	0	0	0	A	151785628	A	A	151785628	3	1	126	1	0	0	0	0	1	0	0	0	2364	943	33	2	447	2	C6orf211	6	151785628	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	54370669	151785628	19329439	63	22398											
TIAM2	26230	broad.mit.edu	37	chr6	155450482	155450482	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatgcaaaagaggaaaagtCattgcatggatggggtcacg	14	8	13	6	1	3	1	3	0	0	1	3	3	3	3	0	4	2	2	0	4	4	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:155450482C>T	uc003qqb.2	+	6	1398	c.125C>T	c.(124-126)TCA>TTA	p.S42L	TIAM2_uc003qqe.2_Missense_Mutation_p.S42L	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	42					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GAGGAAAAGTCATTGCATGGA	0.463													7	37					0	0	0	0	T	155450482	T	T	155450482	3	4	126	1	0	0	0	0	1	0	0	0	15957	838	29	2	127	2	TIAM2	6	155450482	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	3664854	155450482	15664585	64	22399											
VPS41	27072	broad.mit.edu	37	chr7	38796567	38796567	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagagcattgccatagttCttgtcataggtgtacctggt	8	14	10	9	0	2	1	1	0	1	1	3	1	3	1	3	2	3	3	3	2	3	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:38796567C>T	uc003tgy.2	-	19	1592	c.1566G>A	c.(1564-1566)AAG>AAA	p.K522K	VPS41_uc003tgz.2_Silent_p.K497K|VPS41_uc010kxn.2_Silent_p.K433K	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	522					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TGCCATAGTTCTTGTCATAGG	0.299													7	48					0	0	0	0	T	38796567	T	T	38796567	2	4	126	1	0	0	0	0	0	0	0	1	17278	912	32	2		2	VPS41	7	38796567	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08		38796567	120342096	65	22400											
C7orf25	79020	broad.mit.edu	37	chr7	42950074	42950074	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtcttcagcctgctcaatGatgcttttgtcaccatattg	9	15	7	10	0	4	1	3	1	1	0	4	1	4	1	2	0	3	2	2	0	3	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:42950074G>A	uc003thw.2	-	2	890	c.426C>T	c.(424-426)ATC>ATT	p.I142I	C7orf25_uc010kxq.2_Silent_p.I142I|C7orf25_uc003thx.3_Silent_p.I200I|C7orf25_uc010kxr.2_Silent_p.I200I	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	142										skin(1)	1						CCTGCTCAATGATGCTTTTGT	0.507													7	101					0	0	0	0	A	42950074	A	A	42950074	2	1	126	1	0	0	0	0	0	0	0	1	2391	1280	45	2		2	C7orf25	7	42950074	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	4153507	42950074	116188589	66	22401											
LANCL2	55915	broad.mit.edu	37	chr7	55466318	55466318	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgagtcccaggaatgtgtCacaaagtgagttttagaact	12	12	11	6	0	1	3	1	2	0	1	2	4	2	4	1	1	1	1	1	1	4	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:55466318C>T	uc003tqp.2	+	3	1103	c.525C>T	c.(523-525)GTC>GTT	p.V175V		NM_018697	NP_061167	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2	175					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			ovary(1)|skin(1)	2	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			AGGAATGTGTCACAAAGTGAG	0.463													8	40					0	0	0	0	T	55466318	T	T	55466318	2	4	126	1	0	0	0	0	0	0	0	1	8661	813	29	2		2	LANCL2	7	55466318	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	12516244	55466318	103672345	67	22402											
LRCH4	4034	broad.mit.edu	37	chr7	100179491	100179491	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagggcagggattggagctcGttgctgctcacgtcctggta	6	10	16	9	2	1	0	1	0	0	0	3	3	2	2	1	4	3	6	1	4	1	3	rs149222783	byFrequency	TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:100179491G>A	uc003uvj.2	-	4	560	c.507C>T	c.(505-507)AAC>AAT	p.N169N	LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjx.1_RNA	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	169	LRR 6.				nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATTGGAGCTCGTTGCTGCTCA	0.612													5	81					0	0	0	0	A	100179491	A	A	100179491	2	1	126	1	0	0	0	0	0	0	0	1	8985	1136	40	1		1	LRCH4	7	100179491	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	44713173	100179491	58959172	68	22403											
TRIM56	81844	broad.mit.edu	37	chr7	100731849	100731849	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagatggagcccagacccCaaaagaggaaaaagcccaga	17	2	12	10	0	0	4	0	0	0	4	0	7	0	6	4	3	2	0	4	3	4	0			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:100731849C>T	uc003uxq.2	+	3	1487	c.1256C>T	c.(1255-1257)CCA>CTA	p.P419L	TRIM56_uc003uxr.2_Intron	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	419					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					GCCCAGACCCCAAAAGAGGAA	0.642													10	75					0	0	0	0	T	100731849	T	T	100731849	3	4	126	1	0	0	0	0	1	0	0	0	16597	594	21	4	1258	4	TRIM56	7	100731849	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	552358	100731849	58406814	69	22404											
PSMC2	5701	broad.mit.edu	37	chr7	103007958	103007958	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttttgatcctagaggcaatAttaaagtgctgatggccact	11	13	10	7	0	0	3	0	2	0	1	1	3	1	3	2	2	1	3	2	2	5	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:103007958A>G	uc003vbs.2	+	10	1013	c.943A>G	c.(943-945)ATT>GTT	p.I315V	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.I178V	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	315					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TAGAGGCAATATTAAAGTGCT	0.443													59	39					0	0	0	0	G	103007958	G	G	103007958	3	3	126	1	0	0	0	0	1	0	0	0	12748	449	16	5	981	5	PSMC2	7	103007958	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08	2276109	103007958	56130705	70	22405											
PRSS1	5644	broad.mit.edu	37	chr7	142459743	142459743	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaggaagactctgaacaatGacatcatgttaatcaagctc	16	9	7	9	0	3	3	2	2	1	1	4	4	3	4	0	1	2	2	0	1	5	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:142459743G>A	uc003wak.2	+	3	336	c.319G>A	c.(319-321)GAC>AAC	p.D107N	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.D47N	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	107	Peptidase S1.	Charge relay system.			digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			TCTGAACAATGACATCATGTT	0.552									Hereditary_Pancreatitis				17	86					0	0	0	0	A	142459743	A	A	142459743	3	1	126	1	0	0	0	0	1	0	0	0	12676	1290	45	2	329	2	PRSS1	7	142459743	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	39451785	142459743	16678920	71	22406											
FUT10	84750	broad.mit.edu	37	chr8	33246581	33246581	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcttgcactccccatttcCgttccctgagagctgtcaga	6	12	8	15	2	2	2	1	1	1	2	5	3	5	2	4	0	2	3	4	0	0	3	rs17855839		TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr8:33246581C>T	uc003xje.2	-	4	1468	c.1112G>A	c.(1111-1113)CGG>CAG	p.R371Q	FUT10_uc003xjc.2_Missense_Mutation_p.R378Q|FUT10_uc003xjd.2_Missense_Mutation_p.R343Q|FUT10_uc011lbi.1_Missense_Mutation_p.R421Q|FUT10_uc003xjf.2_Missense_Mutation_p.R309Q|FUT10_uc003xjg.2_Missense_Mutation_p.R343Q|FUT10_uc003xjh.2_Missense_Mutation_p.R371Q	NM_032664	NP_116053	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10	371	Lumenal (Potential).				embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			ovary(1)|pancreas(1)	2				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		TCCCCATTTCCGTTCCCTGAG	0.478													37	98					0	0	0	0	T	33246581	T	T	33246581	3	4	126	1	0	0	0	0	1	0	0	0	6136	652	23	1	335	1	FUT10	8	33246581	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08		33246581	113117441	72	22407											
SOX17	64321	broad.mit.edu	37	chr8	55372417	55372417	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgaacagtatctgcacttCgtgtgcaagcctgagatggg	9	12	12	8	1	1	2	0	2	1	1	2	3	1	2	1	1	4	3	1	1	3	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr8:55372417C>T	uc003xsb.3	+	2	1311	c.1107C>T	c.(1105-1107)TTC>TTT	p.F369F		NM_022454	NP_071899	Q9H6I2	SOX17_HUMAN	SRY-box 17	369	Sox C-terminal.				angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			lung(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			ATCTGCACTTCGTGTGCAAGC	0.662													4	22					0	0	0	0	T	55372417	T	T	55372417	2	4	126	1	0	0	0	0	0	0	0	1	15011	883	31	1		1	SOX17	8	55372417	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	22125836	55372417	90991605	73	22408											
FER1L6	654463	broad.mit.edu	37	chr8	125113503	125113503	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacatcttctctttagagaaGatggagtgtaagactcctgc	12	12	9	8	0	2	3	0	0	2	3	4	5	3	4	1	1	2	1	1	1	4	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr8:125113503G>A	uc003yqw.2	+	38	5255	c.5049G>A	c.(5047-5049)AAG>AAA	p.K1683K	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1683	C2 6.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CTTTAGAGAAGATGGAGTGTA	0.483													5	64					0	0	0	0	A	125113503	A	A	125113503	2	1	126	1	0	0	0	0	0	0	0	1	5847	933	33	2		2	FER1L6	8	125113503	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	69741086	125113503	21250519	74	22409											
TRIB1	10221	broad.mit.edu	37	chr8	126442540	126442541	+	5'Flank	INS	-	GGA	GGA																															agcgtgagtcaccaggaggcINSggaggaggtggaggaaaagg																										TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr8:126442540_126442541insGGA	uc003yrx.2	+						TRIB1_uc011lis.1_5'Flank	NM_025195	NP_079471	Q96RU8	TRIB1_HUMAN	G-protein-coupled receptor induced protein						JNK cascade|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|response to lipopolysaccharide	cytoplasm|nucleus	ATP binding|mitogen-activated protein kinase kinase binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			lung(1)	1	all_hematologic(1;4.97e-05)|Ovarian(258;0.00167)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			CACCaggaggcggaggaggtgg	0.495													---	---	---								GGA	126442541	GGA	GGA	126442540	6	5	126	0	1	1	1	0	0	0	0	0	16549	783	27	0		0	TRIB1	8	126442540	5'Flank	INS	-	TCGA-CR-6478-01A-11D-1870-08	1329037	126442540	19921482	75	22410											
RRAGA	10670	broad.mit.edu	37	chr9	19050493	19050493	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggtggtcatgtcagatcCgtcgatcccttctgcggcca	6	11	12	12	3	3	1	2	0	1	1	6	3	5	1	3	3	1	0	3	3	0	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr9:19050493C>T	uc003znj.2	+	1	1122	c.836C>T	c.(835-837)CCG>CTG	p.P279L		NM_006570	NP_006561	Q7L523	RRAGA_HUMAN	Ras-related GTP binding A	279					apoptosis|cellular protein localization|cellular response to amino acid stimulus|positive regulation of cytolysis|positive regulation of TOR signaling cascade|virus-host interaction	Golgi apparatus|lysosome|nucleus	GTP binding|phosphoprotein binding|protein heterodimerization activity|protein homodimerization activity				0						ATGTCAGATCCGTCGATCCCT	0.512													8	134					0	0	0	0	T	19050493	T	T	19050493	3	4	126	1	0	0	0	0	1	0	0	0	13737	652	23	1	838	1	RRAGA	9	19050493	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08		19050493	122162938	76	22411											
RABEPK	10244	broad.mit.edu	37	chr9	127969967	127969967	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgggggagcaaatccaaacAgaagcttctcagacgtgcac	13	7	11	10	1	1	2	1	0	1	2	3	3	2	3	1	2	4	3	1	2	3	2	rs17855990		TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr9:127969967A>G	uc004bpi.2	+	4	351	c.178A>G	c.(178-180)AGA>GGA	p.R60G	RABEPK_uc004bph.1_Missense_Mutation_p.R60G|RABEPK_uc004bpj.2_Missense_Mutation_p.R60G|RABEPK_uc004bpk.2_Missense_Mutation_p.R60G|RABEPK_uc004bpl.1_Missense_Mutation_p.R60G|RABEPK_uc004bpm.2_Missense_Mutation_p.R60G	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	60	Kelch 1.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						AAATCCAAACAGAAGCTTCTC	0.532													8	141					0	0	0	0	G	127969967	G	G	127969967	3	3	126	1	0	0	0	0	1	0	0	0	13028	180	7	5	184	5	RABEPK	9	127969967	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08	108919474	127969967	13243464	77	22412											
C9orf96	169436	broad.mit.edu	37	chr9	136260872	136260872	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatgctccagatcgacccctCggatcgaataacgataaagt	13	8	9	11	4	0	1	0	0	0	1	4	6	1	2	3	1	2	1	3	1	4	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr9:136260872C>T	uc004cdk.2	+	9	909	c.848C>T	c.(847-849)TCG>TTG	p.S283L	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	283	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		ATCGACCCCTCGGATCGAATA	0.493													12	87					0	0	0	0	T	136260872	T	T	136260872	3	4	126	1	0	0	0	0	1	0	0	0	2520	893	31	1	882	1	C9orf96	9	136260872	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	8290905	136260872	4952559	78	22413											
KIAA1462	57608	broad.mit.edu	37	chr10	30316179	30316179	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgggctacctgccagctcGtccattccgttgctaacctc	7	11	8	15	2	0	0	0	0	0	0	4	0	2	0	5	1	5	4	5	1	3	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:30316179G>A	uc001iux.2	-	2	2957	c.2898C>T	c.(2896-2898)GAC>GAT	p.D966D	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.D828D|KIAA1462_uc009xle.1_Silent_p.D966D	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	966										ovary(4)	4						CTGCCAGCTCGTCCATTCCGT	0.567													20	59					0	0	0	0	A	30316179	A	A	30316179	2	1	126	1	0	0	0	0	0	0	0	1	8273	1136	40	1		1	KIAA1462	10	30316179	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08		30316179	105218568	79	22414											
FAM13C	220965	broad.mit.edu	37	chr10	61022290	61022290	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccagaggagcttggctccggGcccgcagcttccggtttccc	4	8	13	16	3	0	1	0	0	0	1	3	2	3	2	5	4	2	5	5	4	0	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:61022290G>A	uc001jkn.2	-	11	1274	c.1140C>T	c.(1138-1140)GGC>GGT	p.G380G	FAM13C_uc001jko.2_Intron|FAM13C_uc010qid.1_Silent_p.G297G|FAM13C_uc010qie.1_Silent_p.G297G|FAM13C_uc010qif.1_Silent_p.G402G|FAM13C_uc001jkp.2_Silent_p.G297G	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	380										ovary(2)	2						TTGGCTCCGGGCCCGCAGCTT	0.547													7	64					0	0	0	0	A	61022290	A	A	61022290	2	1	126	1	0	0	0	0	0	0	0	1	5482	1190	42	4		4	FAM13C	10	61022290	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	30706111	61022290	74512457	80	22415											
ANKRD2	26287	broad.mit.edu	37	chr10	99340627	99340627	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagttccgtcggacagcaCtgcaccgagcttccctggaa	9	7	11	14	3	0	0	0	0	0	0	3	4	2	2	3	2	3	4	3	2	1	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:99340627C>T	uc001knw.2	+	5	762	c.553C>T	c.(553-555)CTG>TTG	p.L185L	ANKRD2_uc009xvu.2_Silent_p.L185L	NM_020349	NP_065082	Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 isoform a	185	ANK 2.				muscle contraction|muscle organ development		structural constituent of muscle				0		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		TCGGACAGCACTGCACCGAGC	0.627													3	9					0	0	0	0	T	99340627	T	T	99340627	2	4	126	1	0	0	0	0	0	0	0	1	647	564	20	4		4	ANKRD2	10	99340627	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	38318337	99340627	36194120	81	22416											
GOT1	2805	broad.mit.edu	37	chr10	101190305	101190305	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctgcggaacctcggcaaaGactgacggaggtgccatatc	10	6	13	12	3	0	2	0	1	0	1	2	4	0	4	3	4	3	1	3	4	3	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:101190305G>A	uc001kpr.2	-	1	226	c.18C>T	c.(16-18)GTC>GTT	p.V6V	GOT1_uc009xwh.2_RNA|GOT1_uc009xwi.2_Silent_p.V6V	NM_002079	NP_002070	P17174	AATC_HUMAN	aspartate aminotransferase 1	6					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding				0		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCTCGGCAAAGACTGACGGAG	0.617													13	93					0	0	0	0	A	101190305	A	A	101190305	2	1	126	1	0	0	0	0	0	0	0	1	6616	929	33	2		2	GOT1	10	101190305	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	1849678	101190305	34344442	82	22417											
SORCS3	22986	broad.mit.edu	37	chr10	106899161	106899161	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccccacaatctaggtaacaActagtggaagagccagctac	14	6	8	13	0	1	1	0	0	1	1	1	2	1	2	3	2	5	2	3	2	7	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:106899161A>C	uc001kyi.1	+	8	1446	c.1219A>C	c.(1219-1221)ACT>CCT	p.T407P		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	407	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTAGGTAACAACTAGTGGAAG	0.458													10	91					0	0	0	0	C	106899161	C	C	106899161	3	2	126	1	0	0	0	0	1	0	0	0	14996	43	2	5	1249	5	SORCS3	10	106899161	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08	5708856	106899161	28635586	83	22418											
WDR11	55717	broad.mit.edu	37	chr10	122668114	122668114	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattatgcccggagtttgaaGaacctcggttttaagcaggg	10	11	13	7	2	0	2	0	1	0	1	1	4	0	3	2	3	3	3	2	3	4	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:122668114G>A	uc010qtf.1	+	29	3802	c.3564G>A	c.(3562-3564)AAG>AAA	p.K1188K	WDR11_uc009xzn.2_3'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	1188						integral to membrane					0						GGAGTTTGAAGAACCTCGGTT	0.438													5	89					0	0	0	0	A	122668114	A	A	122668114	2	1	126	1	0	0	0	0	0	0	0	1	17341	933	33	2		2	WDR11	10	122668114	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	15768953	122668114	12866633	84	22419											
ART1	417	broad.mit.edu	37	chr11	3681285	3681285	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggtgccaccaggtgttccGaggtgtgcacggcctgcgct	4	8	15	14	4	0	0	0	0	0	0	1	1	1	0	5	4	3	3	5	4	0	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:3681285G>T	uc001lye.1	+	3	637	c.536G>T	c.(535-537)CGA>CTA	p.R179L	ART1_uc009yeb.1_Missense_Mutation_p.R179L	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	179		NAD (By similarity).			protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	CAGGTGTTCCGAGGTGTGCAC	0.672													14	18					4.3838e-07	4.71707e-07	1	0	T	3681285	T	T	3681285	3	4	126	1	0	0	0	0	1	0	0	0	999	1058	37	3	542	3	ART1	11	3681285	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08		3681285	131325231	85	22420											
TAF10	6881	broad.mit.edu	37	chr11	6633269	6633269	+	Frame_Shift_Del	DEL	C	-	-																															cagctgctccagccccaggtCcccccgctgtccccgcgggg																										TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:6633269delC	uc001mej.1	-	1	177	c.152delG	c.(151-153)GGAfs	p.G51fs		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	51					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AGCCCCAGGTCCCCCCGCTGT	0.682													---	---	---								-	6633269	-	-	6633269	7	5	126	1	0	1	0	1	0	0	0	0	15580	855	30	0	524	0	TAF10	11	6633269	Frame_Shift_Del	DEL	C	TCGA-CR-6478-01A-11D-1870-08	2951984	6633269	128373247	86	22421											
MS4A4A	51338	broad.mit.edu	37	chr11	60059779	60059779	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggtgtgccccagctgggAaacatggctgtcatacattc	8	10	11	12	0	1	0	1	0	0	0	2	1	1	1	3	3	4	2	3	3	2	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:60059779A>T	uc001noz.2	+	2	133	c.123A>T	c.(121-123)GGA>GGT	p.G41G	MS4A4A_uc001npa.2_Silent_p.G22G|MS4A4A_uc001npb.2_Silent_p.G22G|MS4A4A_uc001npc.2_Silent_p.G22G	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	41	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						CCCAGCTGGGAAACATGGCTG	0.488													12	64					0	0	0	0	T	60059779	T	T	60059779	2	4	126	1	0	0	0	0	0	0	0	1	9915	233	9	5		5	MS4A4A	11	60059779	Silent	SNP	A	TCGA-CR-6478-01A-11D-1870-08	53426510	60059779	74946737	87	22422											
AHNAK	79026	broad.mit.edu	37	chr11	62294494	62294494	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccacatcccccttgattttGggtcctttgagatttagatc	7	16	7	11	0	0	3	0	2	0	2	4	4	3	3	4	1	0	0	4	1	1	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:62294494G>A	uc001ntl.2	-	5	7695	c.7395C>T	c.(7393-7395)CCC>CCT	p.P2465P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2465					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCTTGATTTTGGGTCCTTTGA	0.443													23	216					0	0	0	0	A	62294494	A	A	62294494	2	1	126	1	0	0	0	0	0	0	0	1	414	1335	47	4		4	AHNAK	11	62294494	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	2234715	62294494	72712022	88	22423											
ADRBK1	156	broad.mit.edu	37	chr11	67052618	67052618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagcgcaagtgcctgctcCtcaagatccgcggtgggaaa	10	6	14	11	3	1	1	1	0	0	1	3	3	3	3	3	3	3	2	3	3	3	0			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:67052618C>T	uc009yrn.1	+	20	2130	c.1864C>T	c.(1864-1866)CTC>TTC	p.L622F	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	622	PH.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GTGCCTGCTCCTCAAGATCCG	0.647													21	303					0	0	0	0	T	67052618	T	T	67052618	3	4	126	1	0	0	0	0	1	0	0	0	343	681	24	4	1942	4	ADRBK1	11	67052618	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	4758124	67052618	67953898	89	22424											
SHANK2	22941	broad.mit.edu	37	chr11	70332040	70332040	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagagttggttggttggctgGagttcaacgaaggggactga	9	10	17	5	1	1	2	1	1	0	1	1	5	1	4	0	6	1	5	0	6	2	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:70332040G>A	uc001oqc.2	-	21	4436	c.4358C>T	c.(4357-4359)TCC>TTC	p.S1453F	SHANK2_uc010rqn.1_Missense_Mutation_p.S865F|SHANK2_uc001opz.2_Missense_Mutation_p.S858F|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1074					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGGTTGGCTGGAGTTCAACGA	0.547													8	297					0	0	0	0	A	70332040	A	A	70332040	3	1	126	1	0	0	0	0	1	0	0	0	14330	1174	41	2	1199	2	SHANK2	11	70332040	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	3279422	70332040	64674476	90	22425											
KRTAP5-10	387273	broad.mit.edu	37	chr11	71276860	71276860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccaagggggactgtggctCttgtgggggctccaaagggg	6	8	18	9	0	1	0	0	0	1	0	3	1	3	1	2	7	0	2	2	7	2	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:71276860C>G	uc001oqt.1	+	1	252	c.227C>G	c.(226-228)TCT>TGT	p.S76C		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	76	7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						GACTGTGGCTCTTGTGGGGGC	0.677													94	273					0	0	0	0	G	71276860	G	G	71276860	3	3	126	1	0	0	0	0	1	0	0	0	8599	913	32	2	229	2	KRTAP5-10	11	71276860	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	944820	71276860	63729656	91	22426											
KRTAP5-10	387273	broad.mit.edu	37	chr11	71277239	71277239	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtgctgccagtgtaagatCtgaggctctgaacccagacc	9	9	12	11	0	2	4	0	2	2	2	2	4	2	4	3	1	3	3	3	1	2	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:71277239C>G	uc001oqt.1	+	1	631	c.606C>G	c.(604-606)ATC>ATG	p.I202M		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	202						keratin filament				skin(1)	1						AGTGTAAGATCTGAGGCTCTG	0.313													86	136					0	0	0	0	G	71277239	G	G	71277239	3	3	126	1	0	0	0	0	1	0	0	0	8599	903	32	2	608	2	KRTAP5-10	11	71277239	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	379	71277239	63729277	92	22427											
FAT3	120114	broad.mit.edu	37	chr11	92624271	92624271	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagactcagcatcagactCaagtgtagacatcacatctt	13	10	8	10	0	5	3	4	0	1	3	5	4	5	3	0	1	1	2	0	1	2	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:92624271C>T	uc001pdj.3	+	25	13683	c.13666C>T	c.(13666-13668)CAA>TAA	p.Q4556*	FAT3_uc001pdi.3_Nonsense_Mutation_p.Q1028*	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4588	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCATCAGACTCAAGTGTAGAC	0.507										TCGA Ovarian(4;0.039)			11	16					0	0	0	0	T	92624271	T	T	92624271	4	4	126	1	0	0	0	0	0	1	0	0	5723	827	29	2	13764	2	FAT3	11	92624271	Nonsense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	21347032	92624271	42382245	93	22428											
ZC3H12C	85463	broad.mit.edu	37	chr11	110036199	110036199	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcagacttattccttgcccGataactccacacagccgtgt	9	10	8	14	2	0	1	0	0	0	1	2	2	2	1	4	1	3	1	4	1	2	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:110036199G>A	uc009yxw.2	+	6	2440	c.2389G>A	c.(2389-2391)GAT>AAT	p.D797N	ZC3H12C_uc010rwc.1_Missense_Mutation_p.D798N|ZC3H12C_uc010rwd.1_Missense_Mutation_p.D798N|ZC3H12C_uc001pkr.3_Missense_Mutation_p.D766N	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	797							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		TTCCTTGCCCGATAACTCCAC	0.572													3	40					0	0	0	0	A	110036199	A	A	110036199	3	1	126	1	0	0	0	0	1	0	0	0	17630	1058	37	1	2411	1	ZC3H12C	11	110036199	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	17411928	110036199	24970317	94	22429											
NTM	50863	broad.mit.edu	37	chr11	132081943	132081943	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaattgtagagatttcttCagatatctccattaatgaag	15	14	6	6	0	3	3	1	1	2	2	4	4	3	3	1	0	0	1	1	0	6	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:132081943C>G	uc001qgp.2	+	3	1092	c.428C>G	c.(427-429)TCA>TGA	p.S143*	NTM_uc001qgm.2_Nonsense_Mutation_p.S143*|NTM_uc010sch.1_Nonsense_Mutation_p.S134*|NTM_uc010sci.1_Nonsense_Mutation_p.S143*|NTM_uc010scj.1_Nonsense_Mutation_p.S102*|NTM_uc001qgo.2_Nonsense_Mutation_p.S143*|NTM_uc001qgq.2_Nonsense_Mutation_p.S143*|NTM_uc001qgr.2_5'UTR	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	143	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						GAGATTTCTTCAGATATCTCC	0.393													7	59					0	0	0	0	G	132081943	G	G	132081943	4	3	126	1	0	0	0	0	0	1	0	0	10753	838	29	2	524	2	NTM	11	132081943	Nonsense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	22045744	132081943	2924573	95	22430											
WBP11	51729	broad.mit.edu	37	chr12	14949890	14949890	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgcagctttttacgcttgtCtttcagtactttctcattta	7	19	5	10	2	3	0	2	0	2	0	4	0	3	0	0	0	3	4	0	0	3	9			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:14949890C>G	uc001rci.2	-	5	399	c.238G>C	c.(238-240)GAC>CAC	p.D80H		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	80	Potential.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						TTACGCTTGTCTTTCAGTACT	0.343													27	36					0	0	0	0	G	14949890	G	G	14949890	3	3	126	1	0	0	0	0	1	0	0	0	17326	913	32	2	1719	2	WBP11	12	14949890	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08		14949890	118902005	96	22431											
PDE3A	5139	broad.mit.edu	37	chr12	20799470	20799470	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttacatgctgtttggtaTcttactacacagcctattcc	8	17	6	10	0	1	0	0	0	1	0	2	0	2	0	2	1	5	4	2	1	5	8			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:20799470T>C	uc001reh.1	+	11	2320	c.2298T>C	c.(2296-2298)TAT>TAC	p.Y766Y		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	766	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTGTTTGGTATCTTACTACAC	0.413													12	51					0	0	0	0	C	20799470	C	C	20799470	2	2	126	1	0	0	0	0	0	0	0	1	11691	1442	50	5		5	PDE3A	12	20799470	Silent	SNP	T	TCGA-CR-6478-01A-11D-1870-08	5849580	20799470	113052425	97	22432											
YARS2	51067	broad.mit.edu	37	chr12	32900172	32900172	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttataatgtagaaatttCtttttcctattttaagtaag	13	21	4	3	0	1	1	0	0	1	1	2	1	2	1	1	0	0	2	1	0	7	11			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:32900172C>T	uc001rli.2	-	5	1466	c.1400G>A	c.(1399-1401)AGA>AAA	p.R467K		NM_001040436	NP_001035526	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	467					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity				0	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	GTAGAAATTTCTTTTTCCTAT	0.338													19	30					0	0	0	0	T	32900172	T	T	32900172	3	4	126	1	0	0	0	0	1	0	0	0	17536	913	32	2	37	2	YARS2	12	32900172	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	12100702	32900172	100951723	98	22433											
KIF21A	55605	broad.mit.edu	37	chr12	39726145	39726145	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttatctccctctccattCtccttgactatcttctccct	4	20	1	16	0	5	1	0	1	5	0	9	1	5	1	4	0	0	0	4	0	2	7			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:39726145C>T	uc001rly.2	-	21	3068	c.2922G>A	c.(2920-2922)GAG>GAA	p.E974E	KIF21A_uc001rlv.2_5'UTR|KIF21A_uc001rlw.2_Silent_p.E291E|KIF21A_uc001rlx.2_Silent_p.E961E|KIF21A_uc001rlz.2_Silent_p.E938E|KIF21A_uc010skl.1_Silent_p.E961E	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	974	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CCTCTCCATTCTCCTTGACTA	0.373													12	149					0	0	0	0	T	39726145	T	T	39726145	2	4	126	1	0	0	0	0	0	0	0	1	8327	912	32	2		2	KIF21A	12	39726145	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	6825973	39726145	94125750	99	22434											
LRRK2	120892	broad.mit.edu	37	chr12	40651163	40651163	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggctgtaaaatgctaaatCatctttttgaaggaaggtaa	14	13	10	4	0	2	1	1	1	1	0	2	2	2	2	0	3	1	4	0	3	7	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:40651163C>T	uc001rmg.3	+	12	1523	c.1402C>T	c.(1402-1404)CAT>TAT	p.H468Y	LRRK2_uc001rmh.1_Missense_Mutation_p.H90Y	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	468					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AATGCTAAATCATCTTTTTGA	0.318													13	120					0	0	0	0	T	40651163	T	T	40651163	3	4	126	1	0	0	0	0	1	0	0	0	9083	826	29	2	1448	2	LRRK2	12	40651163	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	925018	40651163	93200732	100	22435											
MLL2	8085	broad.mit.edu	37	chr12	49434415	49434415	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgaggagtcaatgggggctGagcatatgggtcagtgtagg	9	8	18	6	1	2	1	2	1	0	0	2	3	2	2	1	5	1	3	1	5	3	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:49434415G>A	uc001rta.3	-	31	7138	c.7138C>T	c.(7138-7140)CAG>TAG	p.Q2380*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2380	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AATGGGGGCTGAGCATATGGG	0.652			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			4	37					0	0	0	0	A	49434415	A	A	49434415	4	1	126	1	0	0	0	0	0	1	0	0	9674	1299	45	2	9571	2	MLL2	12	49434415	Nonsense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	8783252	49434415	84417480	101	22436											
KRR1	11103	broad.mit.edu	37	chr12	75905362	75905362	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctttttctggccgctccaGcgagggagacgccatttgca	6	10	12	13	3	1	1	0	0	1	1	2	3	2	1	4	2	2	2	4	2	0	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:75905362G>A	uc001sxt.2	-	1	57	c.16C>T	c.(16-18)CTG>TTG	p.L6L	KRR1_uc009zsc.2_Silent_p.L6L|KRR1_uc010stx.1_Silent_p.L6L	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	6					rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						GGCCGCTCCAGCGAGGGAGAC	0.527													6	69					0	0	0	0	A	75905362	A	A	75905362	2	1	126	1	0	0	0	0	0	0	0	1	8485	962	34	4		4	KRR1	12	75905362	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	26470947	75905362	57946533	102	22437											
PPFIA2	8499	broad.mit.edu	37	chr12	81839428	81839428	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctgagggagactgggcttgCcgttttaccaccgtcattct	6	12	11	12	2	2	2	1	1	1	1	2	3	2	2	4	2	2	2	4	2	1	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:81839428C>T	uc001szo.1	-	6	638	c.477G>A	c.(475-477)CGG>CGA	p.R159R	PPFIA2_uc010sue.1_Silent_p.R59R|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	85										ovary(3)|lung(2)|pancreas(1)	6						ACTGGGCTTGCCGTTTTACCA	0.428													3	48					0	0	0	0	T	81839428	T	T	81839428	2	4	126	1	0	0	0	0	0	0	0	1	12365	726	26	4		4	PPFIA2	12	81839428	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	5934066	81839428	52012467	103	22438											
STAB2	55576	broad.mit.edu	37	chr12	104067821	104067821	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgggccctacgtgcagttCtgtcacatccacgccacctg	6	10	10	15	2	2	0	1	0	1	0	3	0	3	0	4	1	2	2	4	1	1	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:104067821C>T	uc001tjw.2	+	23	2694	c.2508C>T	c.(2506-2508)TTC>TTT	p.F836F		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	836	Extracellular (Potential).|EGF-like 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ACGTGCAGTTCTGTCACATCC	0.562													23	53					0	0	0	0	T	104067821	T	T	104067821	2	4	126	1	0	0	0	0	0	0	0	1	15304	912	32	2		2	STAB2	12	104067821	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	22228393	104067821	29784074	104	22439											
USP30	84749	broad.mit.edu	37	chr12	109522853	109522853	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtcagcgccgatgcccttcCctctcccagttgttcccgac	4	11	8	18	3	2	0	1	0	1	0	5	2	4	0	5	0	2	2	5	0	0	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:109522853C>T	uc010sxi.1	+	12	1368	c.1264C>T	c.(1264-1266)CCT>TCT	p.P422S	USP30_uc001tnu.3_Missense_Mutation_p.P391S|USP30_uc001tnw.3_Missense_Mutation_p.P139S	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	422	Cytoplasmic (Potential).				ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1						GATGCCCTTCCCTCTCCCAGT	0.502													29	283					0	0	0	0	T	109522853	T	T	109522853	3	4	126	1	0	0	0	0	1	0	0	0	17129	623	22	4	1310	4	USP30	12	109522853	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	5455032	109522853	24329042	105	22440											
GPR81	27198	broad.mit.edu	37	chr12	123214555	123214555	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccactttgaaatacctgtccGcagccaccaccgtaaggaac	12	7	7	15	2	0	1	0	1	0	0	1	2	1	2	6	1	3	2	6	1	4	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:123214555G>A	uc001ucz.2	-	1	575	c.332C>T	c.(331-333)GCG>GTG	p.A111V	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	111	Cytoplasmic (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		ATACCTGTCCGCAGCCACCAC	0.622													6	41					0	0	0	0	A	123214555	A	A	123214555	3	1	126	1	0	0	0	0	1	0	0	0	6749	1087	38	1	712	1	GPR81	12	123214555	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	13691702	123214555	10637340	106	22441											
FNDC3A	22862	broad.mit.edu	37	chr13	49742771	49742771	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccaggcagaatataattctAtaaagggaactccttcagag	15	10	8	8	0	2	2	1	0	1	2	4	3	4	3	2	2	1	1	2	2	7	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr13:49742771A>G	uc001vcm.2	+	10	1365	c.1060A>G	c.(1060-1062)ATA>GTA	p.I354V	FNDC3A_uc001vcn.2_Missense_Mutation_p.I354V|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.I298V|FNDC3A_uc001vcq.2_Missense_Mutation_p.I298V	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	354	Fibronectin type-III 1.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ATATAATTCTATAAAGGGAAC	0.368													24	56					0	0	0	0	G	49742771	G	G	49742771	3	3	126	1	0	0	0	0	1	0	0	0	6001	449	16	5	1105	5	FNDC3A	13	49742771	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08		49742771	65427107	107	22442											
SLC35F4	341880	broad.mit.edu	37	chr14	58056063	58056063	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgggcaatagaagttcttaTaagtaatttttacaatctgt	14	16	7	4	0	2	1	0	0	2	1	2	1	2	1	0	1	1	3	0	1	8	8			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr14:58056063T>C	uc001xdb.1	-	3	566	c.566A>G	c.(565-567)TAT>TGT	p.Y189C	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.Y30C	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						GAAGTTCTTATAAGTAATTTT	0.393													18	32					0	0	0	0	C	58056063	C	C	58056063	3	2	126	1	0	0	0	0	1	0	0	0	14655	1406	49	5	1023	5	SLC35F4	14	58056063	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08		58056063	49293477	108	22443											
RYR3	6263	broad.mit.edu	37	chr15	33916108	33916108	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttccaaaagagaagatgAgattggagcctgtcaaagaa	17	8	10	6	0	1	4	1	1	0	4	2	7	2	5	2	1	2	0	2	1	6	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr15:33916108A>G	uc001zhi.2	+	20	2528	c.2458A>G	c.(2458-2460)AGA>GGA	p.R820G	RYR3_uc010bar.2_Missense_Mutation_p.R820G	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	820	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGAGAAGATGAGATTGGAGCC	0.488													24	95					0	0	0	0	G	33916108	G	G	33916108	3	3	126	1	0	0	0	0	1	0	0	0	13835	296	11	5	2536	5	RYR3	15	33916108	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08		33916108	68615284	109	22444											
SLC12A6	9990	broad.mit.edu	37	chr15	34526146	34526146	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaggactcgctctagtcccTcggtaagcacctctaggaac	9	9	10	13	2	2	0	0	0	2	0	5	2	3	2	2	3	2	4	2	3	5	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr15:34526146T>A	uc001zhw.2	-	25	3553	c.3389A>T	c.(3388-3390)GAG>GTG	p.E1130V	SLC12A6_uc001zhv.2_Missense_Mutation_p.E1079V|SLC12A6_uc001zhx.2_Missense_Mutation_p.E1115V|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.E1071V|SLC12A6_uc001zib.2_Missense_Mutation_p.E1121V|SLC12A6_uc001zic.2_Missense_Mutation_p.E1130V|SLC12A6_uc010bau.2_Missense_Mutation_p.E1130V|SLC12A6_uc001zid.2_Missense_Mutation_p.E1071V|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Missense_Mutation_p.E942V	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	1130	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CTCTAGTCCCTCGGTAAGCAC	0.453													10	59					0	0	0	0	A	34526146	A	A	34526146	3	1	126	1	0	0	0	0	1	0	0	0	14452	1551	54	5	67	5	SLC12A6	15	34526146	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08	610038	34526146	68005246	110	22445											
DUOX1	53905	broad.mit.edu	37	chr15	45445673	45445673	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctggcctcttccatgatGatgggtgagtaagtgcgaat	8	13	12	8	1	1	3	0	3	1	0	3	4	3	3	3	2	1	1	3	2	2	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr15:45445673G>A	uc001zus.1	+	27	3866	c.3520G>A	c.(3520-3522)GAT>AAT	p.D1174N	DUOX1_uc001zut.1_Missense_Mutation_p.D1174N|DUOX1_uc010bee.1_Missense_Mutation_p.D554N	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	1174	Ferric oxidoreductase.|Interaction with TXNDC11 (By similarity).|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CTTCCATGATGATGGGTGAGT	0.378													18	106					0	0	0	0	A	45445673	A	A	45445673	3	1	126	1	0	0	0	0	1	0	0	0	4822	1290	45	2	3618	2	DUOX1	15	45445673	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	10919527	45445673	57085719	111	22446											
NTN3	4917	broad.mit.edu	37	chr16	2522266	2522266	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggcccagcctgatggcagCggccttctggccttcagcat	5	9	12	15	1	2	1	1	1	1	0	2	1	2	1	4	4	3	2	4	4	0	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr16:2522266C>T	uc002cqj.2	+	1	767	c.564C>T	c.(562-564)AGC>AGT	p.S188S	TBC1D24_uc002cqk.2_5'Flank|TBC1D24_uc002cql.2_5'Flank	NM_006181	NP_006172	O00634	NET3_HUMAN	netrin 3 precursor	188	Laminin N-terminal.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				central_nervous_system(1)	1						CTGATGGCAGCGGCCTTCTGG	0.697													5	16					0	0	0	0	T	2522266	T	T	2522266	2	4	126	1	0	0	0	0	0	0	0	1	10755	767	27	1		1	NTN3	16	2522266	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08		2522266	87832487	112	22447											
CREBBP	1387	broad.mit.edu	37	chr16	3786770	3786770	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggcaatggaagatgtaatCatctccttcacttggaggac	11	11	11	8	0	3	1	2	0	1	1	4	4	3	4	1	4	0	2	1	4	3	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr16:3786770C>T	uc002cvv.2	-	27	4645	c.4441G>A	c.(4441-4443)GAT>AAT	p.D1481N	CREBBP_uc002cvw.2_Missense_Mutation_p.D1443N	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1481	Cys/His-rich.|Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AAGATGTAATCATCTCCTTCA	0.527			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				28	133					0	0	0	0	T	3786770	T	T	3786770	3	4	126	1	0	0	0	0	1	0	0	0	3876	826	29	2	2907	2	CREBBP	16	3786770	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	1264504	3786770	86567983	113	22448											
SETD1A	9739	broad.mit.edu	37	chr16	30977192	30977192	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgactttgtgaactccttgGagctcatggaccgacttggg	8	12	12	9	1	1	2	1	2	0	0	2	5	2	4	2	3	2	1	2	3	1	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr16:30977192G>A	uc002ead.1	+	8	2676	c.1990G>A	c.(1990-1992)GAG>AAG	p.E664K		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	664					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						GAACTCCTTGGAGCTCATGGA	0.622													10	89					0	0	0	0	A	30977192	A	A	30977192	3	1	126	1	0	0	0	0	1	0	0	0	14195	1175	41	2	2016	2	SETD1A	16	30977192	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	27190422	30977192	59377561	114	22449											
ACD	65057	broad.mit.edu	37	chr16	67692699	67692699	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgcacagcattgagctgggGacagtgtacacagcttctcc	10	9	11	11	0	1	1	0	1	1	0	2	2	1	2	1	2	5	5	1	2	1	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr16:67692699G>A	uc002etq.3	-	8	1261	c.924C>T	c.(922-924)GTC>GTT	p.V308V	ACD_uc002etp.3_Silent_p.V305V|ACD_uc002etr.3_Silent_p.V305V|ACD_uc010vjt.1_3'UTR|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	308	Interaction with POT1.				intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		TTGAGCTGGGGACAGTGTACA	0.552													9	51					0	0	0	0	A	67692699	A	A	67692699	2	1	126	1	0	0	0	0	0	0	0	1	135	1161	41	2		2	ACD	16	67692699	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	36715507	67692699	22662054	115	22450											
RANBP10	57610	broad.mit.edu	37	chr16	67778207	67778207	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaccaaggctgtggccattCttggtgtagaagcaggtgcc	9	9	13	10	0	1	1	0	0	1	1	1	1	1	1	3	4	2	3	3	4	3	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr16:67778207C>T	uc002eud.2	-	4	668	c.552G>A	c.(550-552)AAG>AAA	p.K184K	RANBP10_uc010ceo.2_5'UTR|RANBP10_uc010vju.1_Intron|RANBP10_uc010vjv.1_Silent_p.K67K|RANBP10_uc010vjx.1_Silent_p.K184K|RANBP10_uc010vjy.1_Silent_p.K52K	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	184	B30.2/SPRY.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		TGTGGCCATTCTTGGTGTAGA	0.582													6	70					0	0	0	0	T	67778207	T	T	67778207	2	4	126	1	0	0	0	0	0	0	0	1	13091	912	32	2		2	RANBP10	16	67778207	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	85508	67778207	22576546	116	22451											
RTN4RL1	146760	broad.mit.edu	37	chr17	1840605	1840605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtggctgaggttgaccaggtCcacgaagatgtcgtcctgga	8	9	15	9	2	0	3	0	2	0	1	3	5	2	4	3	4	0	2	3	4	1	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:1840605C>T	uc002ftp.2	-	2	530	c.511G>A	c.(511-513)GAC>AAC	p.D171N		NM_178568	NP_848663	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1 precursor	171	LRR 5.				axon regeneration	anchored to plasma membrane	receptor activity				0						TTGACCAGGTCCACGAAGATG	0.627													7	44					0	0	0	0	T	1840605	T	T	1840605	3	4	126	1	0	0	0	0	1	0	0	0	13796	855	30	2	818	2	RTN4RL1	17	1840605	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08		1840605	79354605	117	22452											
TP53	7157	broad.mit.edu	37	chr17	7578394	7578394	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctatctgagcagcgctcaTggtgggggcagcgcctcaca	7	7	14	13	3	3	1	2	1	1	0	3	1	3	1	1	3	3	4	1	3	1	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:7578394T>C	uc002gim.2	-	5	730	c.536A>G	c.(535-537)CAT>CGT	p.H179R	TP53_uc002gig.1_Missense_Mutation_p.H179R|TP53_uc002gih.2_Missense_Mutation_p.H179R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47R|TP53_uc010cng.1_Missense_Mutation_p.H47R|TP53_uc002gii.1_Missense_Mutation_p.H47R|TP53_uc010cnh.1_Missense_Mutation_p.H179R|TP53_uc010cni.1_Missense_Mutation_p.H179R|TP53_uc002gij.2_Missense_Mutation_p.H179R|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86R|TP53_uc002gio.2_Missense_Mutation_p.H47R|TP53_uc010vug.1_Missense_Mutation_p.H140R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	41					0	0	0	0	C	7578394	C	C	7578394	3	2	126	1	0	0	0	0	1	0	0	0	16448	1464	51	5	762	5	TP53	17	7578394	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08	5737789	7578394	73616816	118	22453											
TP53I13	90313	broad.mit.edu	37	chr17	27896356	27896356	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgtcaccaagagtgacctaCacacgagtgagcccagggca	12	5	12	12	1	1	3	1	2	0	1	1	4	1	3	3	1	2	1	3	1	2	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:27896356C>T	uc002hee.2	+	3	200	c.162C>T	c.(160-162)TAC>TAT	p.Y54Y	ABHD15_uc002hed.1_5'Flank	NM_138349	NP_612358	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	54	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane					0				READ - Rectum adenocarcinoma(3;0.236)		GAGTGACCTACACACGAGTGA	0.622													5	29					0	0	0	0	T	27896356	T	T	27896356	2	4	126	1	0	0	0	0	0	0	0	1	16453	489	17	4		4	TP53I13	17	27896356	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	20317962	27896356	53298854	119	22454											
TADA2A	6871	broad.mit.edu	37	chr17	35825582	35825582	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccaggacctgtatgaaacaAtgaggcgatttgcaagaatt	14	10	10	7	1	0	3	0	2	0	1	1	5	1	4	2	2	2	2	2	2	5	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:35825582A>G	uc002hnt.2	+	11	917	c.760A>G	c.(760-762)ATG>GTG	p.M254V	TADA2A_uc002hnu.1_Missense_Mutation_p.M254V|TADA2A_uc002hnv.2_Missense_Mutation_p.M254V|TADA2A_uc002hnw.2_Missense_Mutation_p.M153V|TADA2A_uc010cvb.2_Missense_Mutation_p.M50V	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	254					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						GTATGAAACAATGAGGCGATT	0.433													37	103					0	0	0	0	G	35825582	G	G	35825582	3	3	126	1	0	0	0	0	1	0	0	0	15576	101	4	5	798	5	TADA2A	17	35825582	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08	7929226	35825582	45369628	120	22455											
TNS4	84951	broad.mit.edu	37	chr17	38638646	38638646	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gactcgatgaggaagtgtcgGatgaggtcattgctgtcctc	8	11	14	8	2	1	2	1	2	0	0	5	6	2	4	1	3	1	1	1	3	1	1	rs147623676	byFrequency	TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:38638646G>T	uc010cxb.2	-	7	1688	c.1524C>A	c.(1522-1524)ATC>ATA	p.I508I	TNS4_uc002huu.3_5'Flank	NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	508	SH2.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GGAAGTGTCGGATGAGGTCAT	0.453													11	59					7.03913e-09	7.61882e-09	1	0	T	38638646	T	T	38638646	2	4	126	1	0	0	0	0	0	0	0	1	16411	1164	41	2		2	TNS4	17	38638646	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	2813064	38638646	42556564	121	22456											
KCNH4	23415	broad.mit.edu	37	chr17	40327728	40327728	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctggccggactgggacacatAggtggtgcggaagttcagga	9	7	17	8	2	1	0	1	0	0	0	1	4	1	4	1	7	1	1	1	7	2	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:40327728A>G	uc002hzb.2	-	6	1189	c.856T>C	c.(856-858)TAT>CAT	p.Y286H		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	286	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGGGACACATAGGTGGTGCGG	0.552													3	139					0	0	0	0	G	40327728	G	G	40327728	3	3	126	1	0	0	0	0	1	0	0	0	8073	420	15	5	2241	5	KCNH4	17	40327728	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08	1689082	40327728	40867482	122	22457											
MPP2	4355	broad.mit.edu	37	chr17	41956730	41956730	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggggcctcgatgaacacCacgtaagggacaaactcggc	11	6	12	12	3	1	1	0	1	1	0	3	3	1	2	2	4	2	1	2	4	3	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:41956730C>A	uc010wip.1	-	12	1587	c.1530G>T	c.(1528-1530)GTG>GTT	p.V510V	MPP2_uc002ien.1_Silent_p.V482V|MPP2_uc010wim.1_Silent_p.V454V|MPP2_uc002ieo.1_Silent_p.V465V|MPP2_uc010win.1_Silent_p.V326V|MPP2_uc010wio.1_Silent_p.V454V	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	489	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CGATGAACACCACGTAAGGGA	0.582													18	78					5.3912e-06	5.70104e-06	1	0	A	41956730	A	A	41956730	2	1	126	1	0	0	0	0	0	0	0	1	9787	581	21	4		4	MPP2	17	41956730	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	1629002	41956730	39238480	123	22458											
EPN3	55040	broad.mit.edu	37	chr17	48618855	48618855	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtttggagaccccagccccaGttccaagcaaaatggcacga	12	6	10	13	1	0	1	0	0	0	1	1	3	1	1	5	2	2	4	5	2	3	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:48618855G>A	uc002ira.3	+	9	1820	c.1385G>A	c.(1384-1386)AGT>AAT	p.S462N	SPATA20_uc002irc.2_5'Flank|EPN3_uc010wms.1_Missense_Mutation_p.S490N|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.S435N	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	462						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CCCAGCCCCAGTTCCAAGCAA	0.577													6	50					0	0	0	0	A	48618855	A	A	48618855	3	1	126	1	0	0	0	0	1	0	0	0	5211	1029	36	4	1415	4	EPN3	17	48618855	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	6662125	48618855	32576355	124	22459											
TEX2	55852	broad.mit.edu	37	chr17	62291153	62291153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgggagagctagctaagggcCccgacgaagacgaccctggg	10	4	16	11	3	0	2	0	0	0	2	0	6	0	2	3	3	2	2	3	3	3	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:62291153C>T	uc002jec.2	-	2	598	c.425G>A	c.(424-426)GGG>GAG	p.G142E	TEX2_uc002jed.2_Missense_Mutation_p.G142E|TEX2_uc002jee.2_Missense_Mutation_p.G142E	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	142					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		AGCTAAGGGCCCCGACGAAGA	0.527													11	109					0	0	0	0	T	62291153	T	T	62291153	3	4	126	1	0	0	0	0	1	0	0	0	15847	623	22	4	3023	4	TEX2	17	62291153	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	13672298	62291153	18904057	125	22460											
EPB41L3	23136	broad.mit.edu	37	chr18	5397374	5397375	+	Missense_Mutation	DNP	GC	CA	CA																															agtgctaagcggcaggtggtGcacggtgggttccgtctcta																										TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr18:5397374_5397375GC>CA	uc002kmt.1	-	18	2609_2610	c.2523_2524GC>TG	c.(2521-2526)GTGCAC>GTTGAC	p.H842D	EPB41L3_uc010wzh.1_Missense_Mutation_p.H673D|EPB41L3_uc002kmu.1_Missense_Mutation_p.H620D|EPB41L3_uc010dkq.1_Missense_Mutation_p.H511D|EPB41L3_uc002kms.1_Missense_Mutation_p.H77D|EPB41L3_uc010wze.1_Missense_Mutation_p.H147D|EPB41L3_uc010wzf.1_Missense_Mutation_p.H139D|EPB41L3_uc010wzg.1_Missense_Mutation_p.H114D|EPB41L3_uc010dkr.2_Missense_Mutation_p.H234D	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	842	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GGCAGGTGGTGCACGGTGGGTT	0.569													14	52					0	0	0	0	CA	5397375	CA	CA	5397374	3	2	126	1	0	0	0	0	1	0	0	0	5178	1319	46	4	759	4	EPB41L3	18	5397374	Missense_Mutation	DNP	GC	TCGA-CR-6478-01A-11D-1870-08		5397374	72679874	126	22461											
PSMA8	143471	broad.mit.edu	37	chr18	23772346	23772346	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaggaaaaggaagaagcaGagaagaaaaaatcaaagaaa	28	1	10	2	0	1	4	1	0	0	4	1	7	1	6	0	2	1	1	0	2	12	0			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr18:23772346G>A	uc002kvq.2	+	7	856	c.742G>A	c.(742-744)GAG>AAG	p.E248K	PSMA8_uc002kvo.2_Missense_Mutation_p.E204K|PSMA8_uc002kvp.2_Missense_Mutation_p.E242K|PSMA8_uc002kvr.2_Missense_Mutation_p.E216K	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1	248					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)			GGAAGAAGCAGAGAAGAAAAA	0.303													9	47					0	0	0	0	A	23772346	A	A	23772346	3	1	126	1	0	0	0	0	1	0	0	0	12735	943	33	2	768	2	PSMA8	18	23772346	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	18374972	23772346	54304902	127	22462											
POLI	11201	broad.mit.edu	37	chr18	51820401	51820401	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtagcaaacaggtatcctCtgtatctccttgtgaaccgg	10	11	9	11	1	2	1	0	1	2	0	4	1	3	1	3	2	3	4	3	2	5	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr18:51820401C>T	uc002lfj.3	+	10	1855	c.1787C>T	c.(1786-1788)TCT>TTT	p.S596F	POLI_uc010xds.1_Missense_Mutation_p.S517F|POLI_uc002lfk.3_Missense_Mutation_p.S493F|POLI_uc010dpg.2_Missense_Mutation_p.S192F	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	596	Ser-rich.				DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		CAGGTATCCTCTGTATCTCCT	0.338								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					20	56					0	0	0	0	T	51820401	T	T	51820401	3	4	126	1	0	0	0	0	1	0	0	0	12258	913	32	2	1825	2	POLI	18	51820401	Missense_Mutation	SNP	C	TCGA-CR-6478-01A-11D-1870-08	28048055	51820401	26256847	128	22463											
ZADH2	284273	broad.mit.edu	37	chr18	72914175	72914175	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtgtatctggcactagcAgagaggcctagggccaccac	10	7	12	12	0	1	1	0	0	1	1	1	2	1	1	3	3	1	3	3	3	3	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr18:72914175A>G	uc002llx.2	-	2	598	c.330T>C	c.(328-330)TCT>TCC	p.S110S	ZADH2_uc010dqv.2_5'UTR	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	110						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		TGGCACTAGCAGAGAGGCCTA	0.537													12	108					0	0	0	0	G	72914175	G	G	72914175	2	3	126	1	0	0	0	0	0	0	0	1	17579	175	7	5		5	ZADH2	18	72914175	Silent	SNP	A	TCGA-CR-6478-01A-11D-1870-08	21093774	72914175	5163073	129	22464											
EMR1	2015	broad.mit.edu	37	chr19	6919744	6919744	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagatccaatcatctacactCtggagaacattcaggtttgt	12	12	7	10	0	4	2	2	0	2	2	5	3	5	2	1	2	2	1	1	2	3	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:6919744C>T	uc002mfw.2	+	13	1644	c.1606C>T	c.(1606-1608)CTG>TTG	p.L536L	EMR1_uc010dvc.2_Silent_p.L536L|EMR1_uc010dvb.2_Silent_p.L484L|EMR1_uc010xji.1_Silent_p.L395L|EMR1_uc010xjj.1_Silent_p.L359L	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	536	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					CATCTACACTCTGGAGAACAT	0.458													7	61					0	0	0	0	T	6919744	T	T	6919744	2	4	126	1	0	0	0	0	0	0	0	1	5128	912	32	2		2	EMR1	19	6919744	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08		6919744	52209239	130	22465											
ATG4D	84971	broad.mit.edu	37	chr19	10663623	10663623	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accctggccgagggccatgcTcaggaccacagcctggacga	9	4	13	15	2	1	0	1	0	0	0	1	4	1	2	5	4	2	1	5	4	0	0			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:10663623T>A	uc002mov.2	+	10	1425	c.1305T>A	c.(1303-1305)GCT>GCA	p.A435A	ATG4D_uc010xlh.1_Silent_p.A372A|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_RNA|ATG4D_uc010dxj.2_Silent_p.A102A	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	435					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			AGGGCCATGCTCAGGACCACA	0.672													13	61					0	0	0	0	A	10663623	A	A	10663623	2	1	126	1	0	0	0	0	0	0	0	1	1101	1538	54	5		5	ATG4D	19	10663623	Silent	SNP	T	TCGA-CR-6478-01A-11D-1870-08	3743879	10663623	48465360	131	22466											
CLEC17A	388512	broad.mit.edu	37	chr19	14707912	14707912	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttggactcttcttcatagaCcaggagttgatggaagaact	11	13	10	7	0	3	3	1	1	2	2	3	6	3	6	1	3	1	1	1	3	3	5			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:14707912C>T	uc010dzn.1	+	10	662	c.585C>T	c.(583-585)TAC>TAT	p.Y195Y	CLEC17A_uc002mzh.1_Silent_p.Y178Y|CLEC17A_uc010xnt.1_RNA|CLEC17A_uc010xnu.1_Silent_p.Y195Y|CLEC17A_uc010dzo.1_Silent_p.Y195Y			Q6ZS10	CL17A_HUMAN	SubName: Full=CLEC17A protein;	195	Extracellular (Potential).					cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity				0						TCTTCATAGACCAGGAGTTGA	0.493													3	18					0	0	0	0	T	14707912	T	T	14707912	2	4	126	1	0	0	0	0	0	0	0	1	3516	521	18	4		4	CLEC17A	19	14707912	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	4044289	14707912	44421071	132	22467											
OR7A17	26333	broad.mit.edu	37	chr19	14991892	14991892	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgatgcagcctgcataggtGatgactctgctctgtgtctg	6	13	13	9	0	3	3	0	3	3	0	3	3	3	3	1	1	4	3	1	1	1	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:14991892G>A	uc010xob.1	-	1	276	c.276C>T	c.(274-276)ATC>ATT	p.I92I		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					CTGCATAGGTGATGACTCTGC	0.468													15	77					0	0	0	0	A	14991892	A	A	14991892	2	1	126	1	0	0	0	0	0	0	0	1	11269	1280	45	2		2	OR7A17	19	14991892	Silent	SNP	G	TCGA-CR-6478-01A-11D-1870-08	283980	14991892	44137091	133	22468											
CPAMD8	27151	broad.mit.edu	37	chr19	17057903	17057903	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgtgatgttgttgagtccCaggtcgctgaaggacagaac	9	9	13	10	2	0	4	0	3	0	1	2	5	1	5	2	2	1	3	2	2	2	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:17057903C>T	uc002nfb.2	-	21	2816	c.2784G>A	c.(2782-2784)CTG>CTA	p.L928L		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	881						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TGTTGAGTCCCAGGTCGCTGA	0.592													11	78					0	0	0	0	T	17057903	T	T	17057903	2	4	126	1	0	0	0	0	0	0	0	1	3810	581	21	4		4	CPAMD8	19	17057903	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	2066011	17057903	42071080	134	22469											
KIAA1683	80726	broad.mit.edu	37	chr19	18376204	18376204	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatgtgtctgggaatgcaTcttgctcagacaggtgtcca	9	11	12	9	0	3	2	1	0	2	2	4	3	4	3	1	2	2	2	1	2	1	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:18376204T>A	uc002nin.2	-	3	2362	c.2146A>T	c.(2146-2148)ATG>TTG	p.M716L	KIAA1683_uc010ebn.2_Missense_Mutation_p.M716L|KIAA1683_uc010xqe.1_Missense_Mutation_p.M670L	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	716						mitochondrion				ovary(2)	2						TGGGAATGCATCTTGCTCAGA	0.627													8	54					0	0	0	0	A	18376204	A	A	18376204	3	1	126	1	0	0	0	0	1	0	0	0	8290	1435	50	5	1965	5	KIAA1683	19	18376204	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08	1318301	18376204	40752779	135	22470											
ZNF90	7643	broad.mit.edu	37	chr19	20229657	20229657	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaatgtcaagaatgtgacAaagtcttcaaacgctcctca	16	9	6	10	1	4	2	3	1	1	1	5	2	5	2	1	0	1	1	1	0	5	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:20229657A>G	uc002nor.2	+	4	1433	c.1294A>G	c.(1294-1296)AAA>GAA	p.K432E	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	432	C2H2-type 10.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AGAATGTGACAAAGTCTTCAA	0.413													3	13					0	0	0	0	G	20229657	G	G	20229657	3	3	126	1	0	0	0	0	1	0	0	0	18266	131	5	5	1308	5	ZNF90	19	20229657	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08	1853453	20229657	38899326	136	22471											
ZNF536	9745	broad.mit.edu	37	chr19	31039805	31039805	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actctgggagagcagaagagCggtgcatggaccggccacgt	10	5	16	10	3	1	3	0	0	1	3	1	5	1	4	2	4	3	2	2	4	1	0	rs147863190		TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:31039805C>T	uc002nsu.1	+	4	3417	c.3279C>T	c.(3277-3279)AGC>AGT	p.S1093S	ZNF536_uc010edd.1_Silent_p.S1093S	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1093					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					AGCAGAAGAGCGGTGCATGGA	0.537													11	39					0	0	0	0	T	31039805	T	T	31039805	2	4	126	1	0	0	0	0	0	0	0	1	18041	767	27	1		1	ZNF536	19	31039805	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08	10810148	31039805	28089178	137	22472											
TNNT1	7138	broad.mit.edu	37	chr19	55652591	55652591	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaccagctcctcttcctccTtcttccgctgctcgaaatgt	6	13	5	17	2	2	0	0	0	2	0	7	1	6	0	5	0	3	3	5	0	2	3			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:55652591T>G	uc002qjb.3	-	8	361	c.272A>C	c.(271-273)AAG>ACG	p.K91T	TNNT1_uc002qiz.3_Missense_Mutation_p.K21T|TNNT1_uc002qja.3_Missense_Mutation_p.K21T|TNNT1_uc002qjc.3_Missense_Mutation_p.K91T|TNNT1_uc002qje.3_Missense_Mutation_p.K80T|TNNT1_uc002qjd.3_Missense_Mutation_p.K80T|TNNT1_uc002qjf.2_Missense_Mutation_p.K87T	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	91					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		CTCTTCCTCCTTCTTCCGCTG	0.592											OREG0025677	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	50					0	0	0	0	G	55652591	G	G	55652591	3	3	126	1	0	0	0	0	1	0	0	0	16396	1609	56	5	592	5	TNNT1	19	55652591	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08	24612786	55652591	3476392	138	22473											
C20orf103	24141	broad.mit.edu	37	chr20	9496129	9496129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaaatcatggcagaacaaGaagtggaaaatctctcaggc	16	7	9	9	0	4	2	3	0	1	2	5	3	4	3	0	3	1	1	0	3	6	0			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr20:9496129G>A	uc002wni.1	+	2	323	c.94G>A	c.(94-96)GAA>AAA	p.E32K	C20orf103_uc010zrc.1_Missense_Mutation_p.E32K	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	32	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			GGCAGAACAAGAAGTGGAAAA	0.498													8	44					0	0	0	0	A	9496129	A	A	9496129	3	1	126	1	0	0	0	0	1	0	0	0	2085	943	33	2	100	2	C20orf103	20	9496129	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08		9496129	53529391	139	22474											
SEC23B	10483	broad.mit.edu	37	chr20	18529385	18529385	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatgatccagcccattctcTactcttactcctttcatggg	7	15	5	14	0	4	1	2	1	2	0	7	1	6	1	3	1	3	0	3	1	2	4			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr20:18529385T>A	uc002wqz.1	+	16	2319	c.1876T>A	c.(1876-1878)TAC>AAC	p.Y626N	SEC23B_uc002wra.1_Missense_Mutation_p.Y626N|SEC23B_uc002wrb.1_Missense_Mutation_p.Y626N|SEC23B_uc010zsb.1_Missense_Mutation_p.Y608N|SEC23B_uc002wrc.1_Missense_Mutation_p.Y626N	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	626					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						GCCCATTCTCTACTCTTACTC	0.438													14	52					0	0	0	0	A	18529385	A	A	18529385	3	1	126	1	0	0	0	0	1	0	0	0	14057	1522	53	5	1934	5	SEC23B	20	18529385	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08	9033256	18529385	44496135	140	22475											
MOCS3	27304	broad.mit.edu	37	chr20	49575960	49575962	+	In_Frame_Del	DEL	TGC	-	-																															cctggttaatgacgcatgtgTgctggcgggtcggcccctcg																										TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr20:49575960_49575962delTGC	uc002xvy.1	+	1	598_600	c.581_583delTGC	c.(580-585)GTGCTG>GTG	p.L195del	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	195					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						GACGCATGTGTGCTGGCGGGTCG	0.596													---	---	---								-	49575962	-	-	49575960	7	5	126	1	0	1	0	1	0	0	0	0	9745	1696	59	0	583	0	MOCS3	20	49575960	In_Frame_Del	DEL	TGC	TCGA-CR-6478-01A-11D-1870-08	31046575	49575960	13449560	141	22476											
BRWD1	54014	broad.mit.edu	37	chr21	40604128	40604128	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccatttttctccatggcTccttattagggttcagttca	7	17	7	10	0	3	0	2	0	1	0	6	1	5	0	3	2	0	3	3	2	2	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr21:40604128T>A	uc002yxk.1	-	25	3114	c.2975A>T	c.(2974-2976)GAG>GTG	p.E992V	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.E992V|BRWD1_uc010god.1_5'Flank	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	992					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TCTCCATGGCTCCTTATTAGG	0.299													15	39					0	0	0	0	A	40604128	A	A	40604128	3	1	126	1	0	0	0	0	1	0	0	0	1530	1551	54	5	4298	5	BRWD1	21	40604128	Missense_Mutation	SNP	T	TCGA-CR-6478-01A-11D-1870-08		40604128	7525767	142	22477											
MTP18	51537	broad.mit.edu	37	chr22	30824464	30824464	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tacaggtcggtggatttcctCctggactccagcctgcgcaa	7	10	11	13	2	0	0	0	0	0	0	4	2	3	2	4	4	3	1	4	4	2	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr22:30824464C>T	uc003ahw.1	+	4	592	c.444C>T	c.(442-444)CTC>CTT	p.L148L	SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Missense_Mutation_p.S59F|MTP18_uc003ahv.1_Silent_p.L310L|MTP18_uc010gvy.1_Missense_Mutation_p.S51F|MTP18_uc003ahx.1_Missense_Mutation_p.P71S	NM_016498	NP_057582	Q9UDX5	MTFP1_HUMAN	mitochondrial protein 18 kDa isoform a	148	Helical; (Potential).				apoptosis|carbon utilization	integral to membrane|mitochondrial inner membrane	carbonate dehydratase activity|zinc ion binding				0						TGGATTTCCTCCTGGACTCCA	0.587													10	35					0	0	0	0	T	30824464	T	T	30824464	2	4	126	1	0	0	0	0	0	0	0	1	10008	855	30	2		2	MTP18	22	30824464	Silent	SNP	C	TCGA-CR-6478-01A-11D-1870-08		30824464	20480102	143	22478											
PTCHD1	139411	broad.mit.edu	37	chrX	23353314	23353314	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccagaaagccaacatgctgGaccagcatcacaccgacctg	13	5	8	15	1	1	1	1	0	0	1	2	3	2	2	5	1	4	2	5	1	2	0			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chrX:23353314G>A	uc004dal.3	+	1	330	c.322G>A	c.(322-324)GAC>AAC	p.D108N	PTCHD1_uc010nfu.1_Missense_Mutation_p.D108N	NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	108					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						CAACATGCTGGACCAGCATCA	0.677													7	26					0	0	0	0	A	23353314	A	A	23353314	3	1	126	1	0	0	0	0	1	0	0	0	12794	1174	41	2	324	2	PTCHD1	23	23353314	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08		23353314	131917246	144	22479											
AWAT1	158833	broad.mit.edu	37	chrX	69455943	69455943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggcgttcggcctgggtaaGgaactggtgtgtctggaccc	6	9	16	10	2	1	0	0	0	1	0	2	2	1	2	2	6	1	2	2	6	2	2			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chrX:69455943G>A	uc004dxy.2	+	3	250	c.209G>A	c.(208-210)AGG>AAG	p.R70K		NM_001013579	NP_001013597	Q58HT5	AWAT1_HUMAN	wax synthase 1	70					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			ovary(3)	3						GCCTGGGTAAGGAACTGGTGT	0.517													11	91					0	0	0	0	A	69455943	A	A	69455943	3	1	126	1	0	0	0	0	1	0	0	0	1236	1000	35	4	219	4	AWAT1	23	69455943	Missense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	46102629	69455943	85814617	145	22480											
MED12	9968	broad.mit.edu	37	chrX	70356763	70356763	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccgggtcggagcggcccttAtggtgtgacagtgcctccgg	4	8	16	13	4	0	1	0	1	0	0	2	2	1	2	4	5	2	0	4	5	1	1			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chrX:70356763A>G	uc004dyy.2	+	38	5634	c.5435A>G	c.(5434-5436)TAT>TGT	p.Y1812C	MED12_uc011mpq.1_Missense_Mutation_p.Y1812C|MED12_uc004dyz.2_Missense_Mutation_p.Y1812C|MED12_uc004dza.2_Missense_Mutation_p.Y1659C|MED12_uc010nla.2_Missense_Mutation_p.Y438C	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1812	Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					AGCGGCCCTTATGGTGTGACA	0.592													15	42					0	0	0	0	G	70356763	G	G	70356763	3	3	126	1	0	0	0	0	1	0	0	0	9481	449	16	5	5585	5	MED12	23	70356763	Missense_Mutation	SNP	A	TCGA-CR-6478-01A-11D-1870-08	900820	70356763	84913797	146	22481											
CT45A5	441521	broad.mit.edu	37	chrX	134947917	134947917	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cactacttacttcgtccaagGcatcggatttccttcactac	9	13	5	14	2	1	0	1	0	0	0	5	1	3	1	2	2	3	1	2	2	4	6			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chrX:134947917G>T	uc004eze.2	-	3	653	c.408C>A	c.(406-408)TGC>TGA	p.C136*	CT45A5_uc011mvu.1_Nonsense_Mutation_p.C136*	NM_001007551	NP_001007552	Q6NSH3	CT455_HUMAN	cancer/testis antigen family 45, member A5	136											0						TTCGTCCAAGGCATCGGATTT	0.398													26	95					2.27525e-19	2.49194e-19	1	0	T	134947917	T	T	134947917	4	4	126	1	0	0	0	0	0	1	0	0	4005	1195	42	4	173	4	CT45A5	23	134947917	Nonsense_Mutation	SNP	G	TCGA-CR-6478-01A-11D-1870-08	64591154	134947917	20322643	147	22482											
TMEM222	84065	broad.mit.edu	37	chr1	27657224	27657224	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacaggtggtttttccccAtcatcggccacatgggcatc	7	11	9	14	1	2	0	2	0	0	0	5	0	3	0	3	4	0	2	3	4	0	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:27657224A>G	uc001bnr.3	+	2	261	c.208A>G	c.(208-210)ATC>GTC	p.I70V	TMEM222_uc001bns.3_RNA|TMEM222_uc001bnt.3_RNA|TMEM222_uc001bnu.3_Intron	NM_032125	NP_115501	Q9H0R3	TM222_HUMAN	transmembrane protein 222	70	Helical; (Potential).					integral to membrane	protein binding				0						GTTTTTCCCCATCATCGGCCA	0.582													74	148					0	0	0	0	G	27657224	G	G	27657224	3	3	127	1	0	0	0	0	1	0	0	0	16211	217	8	5	214	5	TMEM222	1	27657224	Missense_Mutation	SNP	A	TCGA-CR-6480-01A-11D-1870-08		27657224	221593397	1	22483											
EIF2C4	192670	broad.mit.edu	37	chr1	36291577	36291577	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctatcattgagttcatgtgtGaggttttagacattcagaac	11	15	9	6	0	3	4	3	2	0	2	3	4	3	4	0	1	1	2	0	1	3	6			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:36291577G>C	uc001bzj.1	+	6	866	c.676G>C	c.(676-678)GAG>CAG	p.E226Q		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	226	PAZ.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTTCATGTGTGAGGTTTTAGA	0.418													60	91					0	0	0	0	C	36291577	C	C	36291577	3	2	127	1	0	0	0	0	1	0	0	0	5030	1291	45	2	698	2	EIF2C4	1	36291577	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	8634353	36291577	212959044	2	22484											
IL12RB2	3595	broad.mit.edu	37	chr1	67787297	67787297	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattgcagatgcgtgcaagaGaggcgatgtgactgtgaagc	11	9	15	6	2	0	4	0	2	0	2	0	6	0	4	0	1	4	2	0	1	3	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:67787297G>C	uc001ddu.2	+	3	729	c.89G>C	c.(88-90)AGA>ACA	p.R30T	IL12RB2_uc010oqi.1_Missense_Mutation_p.R30T|IL12RB2_uc010oqj.1_Missense_Mutation_p.R30T|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.R30T|IL12RB2_uc010oqm.1_Missense_Mutation_p.R30T|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	30	Extracellular (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						GCGTGCAAGAGAGGCGATGTG	0.393													33	66					0	0	0	0	C	67787297	C	C	67787297	3	2	127	1	0	0	0	0	1	0	0	0	7666	942	33	2	95	2	IL12RB2	1	67787297	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	31495720	67787297	181463324	3	22485											
C1orf173	127254	broad.mit.edu	37	chr1	75037078	75037078	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctagccctgaggtcttcCgctccagggctcctggagtg	4	10	13	14	1	1	1	0	1	1	0	5	2	5	2	5	3	1	2	5	3	1	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:75037078C>T	uc001dgg.2	-	14	4535	c.4316G>A	c.(4315-4317)CGG>CAG	p.R1439Q		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1439	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TGAGGTCTTCCGCTCCAGGGC	0.612													14	126					0	0	0	0	T	75037078	T	T	75037078	3	4	127	1	0	0	0	0	1	0	0	0	2023	652	23	1	280	1	C1orf173	1	75037078	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	7249781	75037078	174213543	4	22486											
ATXN7L2	127002	broad.mit.edu	37	chr1	110028684	110028684	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtttctcctctaggggctGagctggaggagagtagcaaa	9	10	15	7	0	2	2	0	1	2	1	3	4	2	3	1	4	2	5	1	4	3	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:110028684G>A	uc001dxr.2	+	2	148	c.133G>A	c.(133-135)GAG>AAG	p.E45K	ATXN7L2_uc001dxs.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	45										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		TCTAGGGGCTGAGCTGGAGGA	0.527													33	43					0	0	0	0	A	110028684	A	A	110028684	3	1	127	1	0	0	0	0	1	0	0	0	1219	1291	45	2	139	2	ATXN7L2	1	110028684	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	34991606	110028684	139221937	5	22487											
CTSS	1520	broad.mit.edu	37	chr1	150724308	150724308	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgatgcccttgttatcaatGatgtactggaaagccgttgt	9	14	10	8	2	1	1	1	1	0	0	2	3	1	2	2	1	3	3	2	1	4	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:150724308G>A	uc001evn.2	-	5	709	c.576C>T	c.(574-576)ATC>ATT	p.I192I	CTSS_uc010pcj.1_Silent_p.I142I|CTSS_uc001evo.1_Silent_p.I192I	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	192					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			TGTTATCAATGATGTACTGGA	0.468													48	88					0	0	0	0	A	150724308	A	A	150724308	2	1	127	1	0	0	0	0	0	0	0	1	4058	1280	45	2		2	CTSS	1	150724308	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	40695624	150724308	98526313	6	22488			1	27		3	3	173	G		2.632191e-07
CTSS	1520	broad.mit.edu	37	chr1	150724458	150724458	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagggcccccacagcactGaaagcccagcaagcaccaca	13	2	8	18	0	0	1	0	1	0	0	1	1	1	1	5	1	4	3	5	1	2	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:150724458G>A	uc001evn.2	-	5	559	c.426C>T	c.(424-426)TTC>TTT	p.F142F	CTSS_uc010pcj.1_Silent_p.F92F|CTSS_uc001evo.1_Silent_p.F142F	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	142					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			CCACAGCACTGAAAGCCCAGC	0.478													15	32					0	0	0	0	A	150724458	A	A	150724458	2	1	127	1	0	0	0	0	0	0	0	1	4058	1281	45	2		2	CTSS	1	150724458	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	150	150724458	98526163	7	22489			1	27		3	3	173	G		2.632191e-07
CTSS	1520	broad.mit.edu	37	chr1	150724480	150724480	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcccagcaagcaccacaaGaaccctaaaacagatacaag	20	2	6	13	0	0	2	0	0	0	2	0	2	0	2	3	0	6	2	3	0	8	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:150724480G>T	uc001evn.2	-	5	537	c.404C>A	c.(403-405)TCT>TAT	p.S135Y	CTSS_uc010pcj.1_Missense_Mutation_p.S85Y|CTSS_uc001evo.1_Missense_Mutation_p.S135Y	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	135					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			AGCACCACAAGAACCCTAAAA	0.493													15	28					6.31663e-08	6.63444e-08	1	0	T	150724480	T	T	150724480	3	4	127	1	0	0	0	0	1	0	0	0	4058	942	33	2	607	2	CTSS	1	150724480	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	22	150724480	98526141	8	22490			1	27		3	3	173	G		2.632191e-07
RASAL2	9462	broad.mit.edu	37	chr1	178433454	178433454	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccacaatgtccccagtagaGaggacagcagcctgggttct	10	7	12	12	0	1	1	0	0	1	1	2	3	2	2	4	2	2	3	4	2	2	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:178433454G>A	uc001glr.2	+	13	2996	c.2871G>A	c.(2869-2871)GAG>GAA	p.E957E	RASAL2_uc001glq.2_Silent_p.E1098E|RASAL2_uc009wxc.2_Silent_p.E471E	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	957					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						CCCCAGTAGAGAGGACAGCAG	0.478													15	23					0	0	0	0	A	178433454	A	A	178433454	2	1	127	1	0	0	0	0	0	0	0	1	13129	933	33	2		2	RASAL2	1	178433454	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	27708974	178433454	70817167	9	22491											
TPR	7175	broad.mit.edu	37	chr1	186327736	186327736	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatctctctcaagtacagatGattgcttgttggctttatca	9	17	7	8	0	3	2	2	1	2	1	5	2	3	2	0	1	2	4	0	1	4	7			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:186327736G>A	uc001grv.2	-	13	1733	c.1436C>T	c.(1435-1437)TCA>TTA	p.S479L	TPR_uc010pop.1_Missense_Mutation_p.S555L	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	479	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		AAGTACAGATGATTGCTTGTT	0.318			T	NTRK1	papillary thyroid								28	75					0	0	0	0	A	186327736	A	A	186327736	3	1	127	1	0	0	0	0	1	0	0	0	16483	1294	45	2	5811	2	TPR	1	186327736	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	7894282	186327736	62922885	10	22492											
RRP15	51018	broad.mit.edu	37	chr1	218475717	218475717	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagggtgatgctgagccctGtgacaaagaaaatgaaaatg	15	8	13	5	0	0	6	0	5	0	1	0	6	0	6	1	1	2	1	1	1	5	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:218475717G>T	uc001hlj.2	+	2	251	c.221G>T	c.(220-222)TGT>TTT	p.C74F		NM_016052	NP_057136	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog	74						mitochondrion|nucleolus	protein binding				0				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		GCTGAGCCCTGTGACAAAGAA	0.428													23	30					1.64293e-13	1.77013e-13	1	0	T	218475717	T	T	218475717	3	4	127	1	0	0	0	0	1	0	0	0	13752	1377	48	4	227	4	RRP15	1	218475717	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	32147981	218475717	30774904	11	22493											
TMEM63A	9725	broad.mit.edu	37	chr1	226041387	226041387	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgatcatgcggaaggtataGaggatgagacctggcagccg	12	7	15	7	2	1	3	1	2	0	2	1	6	1	5	2	4	2	2	2	4	3	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:226041387G>C	uc001hpm.1	-	19	1990	c.1740C>G	c.(1738-1740)CTC>CTG	p.L580L		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	580						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					GGAAGGTATAGAGGATGAGAC	0.602													5	5					0	0	0	0	C	226041387	C	C	226041387	2	2	127	1	0	0	0	0	0	0	0	1	16256	929	33	2		2	TMEM63A	1	226041387	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	7565670	226041387	23209234	12	22494											
HEATR1	55127	broad.mit.edu	37	chr1	236718636	236718636	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggttcaaggtgtcagcaaaAggcttcactaagtggccggc	10	9	13	9	1	3	0	3	0	0	0	3	0	3	0	1	5	1	3	1	5	4	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:236718636A>G	uc001hyd.1	-	41	6008	c.5883T>C	c.(5881-5883)CCT>CCC	p.P1961P	HEATR1_uc009xgh.1_Silent_p.P1123P	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1961					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TGTCAGCAAAAGGCTTCACTA	0.483													3	122					0	0	0	0	G	236718636	G	G	236718636	2	3	127	1	0	0	0	0	0	0	0	1	7066	59	3	5		5	HEATR1	1	236718636	Silent	SNP	A	TCGA-CR-6480-01A-11D-1870-08	10677249	236718636	12531985	13	22495											
RYR2	6262	broad.mit.edu	37	chr1	237713931	237713931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaacaaggacagcctccgcGaggctgtgcgcacgctgctg	8	5	13	15	4	0	0	0	0	0	0	1	2	1	1	3	2	4	4	3	2	2	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:237713931G>A	uc001hyl.1	+	27	3274	c.3154G>A	c.(3154-3156)GAG>AAG	p.E1052K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1052	Cytoplasmic (By similarity).|2.|B30.2/SPRY 2.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAGCCTCCGCGAGGCTGTGCG	0.493													6	6					0	0	0	0	A	237713931	A	A	237713931	3	1	127	1	0	0	0	0	1	0	0	0	13834	1059	37	1	3260	1	RYR2	1	237713931	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	995295	237713931	11536690	14	22496											
KIF26B	55083	broad.mit.edu	37	chr1	245850334	245850334	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctgagatgggagatgactCtttcaacaaagcagccccca	12	8	10	11	0	3	3	1	2	2	2	3	5	3	3	2	1	3	1	2	1	2	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr1:245850334C>G	uc001ibf.1	+	12	4489	c.4049C>G	c.(4048-4050)TCT>TGT	p.S1350C	KIF26B_uc001ibg.1_Missense_Mutation_p.S968C|KIF26B_uc001ibh.1_Missense_Mutation_p.S592C	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1350					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GGAGATGACTCTTTCAACAAA	0.557													13	19					0	0	0	0	G	245850334	G	G	245850334	3	3	127	1	0	0	0	0	1	0	0	0	8334	913	32	2	4095	2	KIF26B	1	245850334	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	8136403	245850334	3400287	15	22497											
NT5C1B	93034	broad.mit.edu	37	chr2	18765360	18765360	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcttgcagaataccttgacGaagcggaacgccgggcccgg	10	5	14	12	5	0	2	0	1	0	1	0	4	0	3	3	3	5	2	3	3	4	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:18765360G>A	uc002rcz.2	-	6	1169	c.1065C>T	c.(1063-1065)TTC>TTT	p.F355F	NT5C1B_uc002rcy.2_Silent_p.F355F|NT5C1B_uc010exr.2_Silent_p.F297F|NT5C1B_uc010yju.1_Silent_p.F295F|NT5C1B_uc002rda.2_Silent_p.F295F|NT5C1B_uc010yjv.1_Silent_p.F372F|NT5C1B_uc010yjw.1_Silent_p.F338F|NT5C1B_uc010exs.2_Silent_p.F357F|NT5C1B_uc002rdb.1_Silent_p.F147F	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	355					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				ATACCTTGACGAAGCGGAACG	0.572													29	67					0	0	0	0	A	18765360	A	A	18765360	2	1	127	1	0	0	0	0	0	0	0	1	10740	1049	37	1		1	NT5C1B	2	18765360	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08		18765360	224434013	16	22498											
TP53I3	9540	broad.mit.edu	37	chr2	24302332	24302332	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accttattgtccctagacctCagcaaactggtgatcagact	11	11	7	12	0	2	3	2	1	0	2	3	3	3	3	3	1	2	1	3	1	3	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:24302332C>T	uc002rey.1	-	5	858	c.798G>A	c.(796-798)CTG>CTA	p.L266L	LOC375190_uc002rew.2_Intron|TP53I3_uc002rex.1_Intron|TP53I3_uc002rez.1_Silent_p.L266L|TP53I3_uc010ykk.1_Silent_p.L177L	NM_147184	NP_671713	Q53FA7	QORX_HUMAN	tumor protein p53 inducible protein 3	266	NADP.				induction of apoptosis by oxidative stress|NADP metabolic process		NADPH binding|NADPH:quinone reductase activity|protein homodimerization activity|quinone binding|zinc ion binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCTAGACCTCAGCAAACTGG	0.438													35	90					0	0	0	0	T	24302332	T	T	24302332	2	4	127	1	0	0	0	0	0	0	0	1	16454	813	29	2		2	TP53I3	2	24302332	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08	5536972	24302332	218897041	17	22499											
DOK1	1796	broad.mit.edu	37	chr2	74784055	74784055	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctcggagcacaaagcccctCcttgctcccaagccccaggg	8	5	9	19	1	0	0	0	0	0	0	3	1	2	1	7	2	4	2	7	2	2	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:74784055C>A	uc002sms.2	+	5	1282	c.1260C>A	c.(1258-1260)CTC>CTA	p.L420L	LOXL3_uc002smp.1_5'Flank|LOXL3_uc002smq.1_5'Flank|LOXL3_uc010ffn.1_5'Flank|DOK1_uc002smr.2_Silent_p.L281L|DOK1_uc010ffo.2_Silent_p.L281L|DOK1_uc002smt.2_Silent_p.L206L|DOK1_uc002smu.2_Silent_p.L206L|DOK1_uc010yrz.1_Silent_p.L409L|DOK1_uc002smv.2_Silent_p.L281L|DOK1_uc002smw.1_Silent_p.L206L	NM_001381	NP_001372	Q99704	DOK1_HUMAN	docking protein 1	420	Pro-rich.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding				0						CAAAGCCCCTCCTTGCTCCCA	0.617													81	147					1.16668e-32	1.2903e-32	1	0	A	74784055	A	A	74784055	2	1	127	1	0	0	0	0	0	0	0	1	4718	842	30	2		2	DOK1	2	74784055	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08	50481723	74784055	168415318	18	22500											
ARID5A	10865	broad.mit.edu	37	chr2	97215191	97215195	+	Frame_Shift_Del	DEL	AGCAG	-	-																															ggtgccccatctcggcttcaAgcagagtgcgtccctggggt																										TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:97215191_97215195delAGCAG	uc002swe.2	+	3	354_358	c.254_258delAGCAG	c.(253-258)AAGCAGfs	p.K85fs	ARID5A_uc010yuq.1_5'UTR|ARID5A_uc002swf.2_Intron|ARID5A_uc002swg.2_Intron	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A	85_86	ARID.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding				0						CTCGGCTTCAAGCAGAGTGCGTCCC	0.59													---	---	---								-	97215195	-	-	97215191	7	5	127	1	0	1	0	1	0	0	0	0	921	72	3	0	264	0	ARID5A	2	97215191	Frame_Shift_Del	DEL	AGCAG	TCGA-CR-6480-01A-11D-1870-08	22431136	97215191	145984182	19	22501											
NCK2	8440	broad.mit.edu	37	chr2	106498358	106498358	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaccctgcgcacgccccAcagataagctacaccgggcc	9	4	9	19	3	0	1	0	0	0	1	0	1	0	1	5	1	4	3	5	1	2	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:106498358A>G	uc002tdg.2	+	4	1243	c.801A>G	c.(799-801)CCA>CCG	p.P267P	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Silent_p.P267P	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	267					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						CGCACGCCCCACAGATAAGCT	0.667													19	32					0	0	0	0	G	106498358	G	G	106498358	2	3	127	1	0	0	0	0	0	0	0	1	10274	146	6	5		5	NCK2	2	106498358	Silent	SNP	A	TCGA-CR-6480-01A-11D-1870-08	9283167	106498358	136701015	20	22502											
KIF5C	3800	broad.mit.edu	37	chr2	149838001	149838001	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagctggctgtcaattatGaccagaaatcacaggaagtg	14	8	12	7	0	2	2	2	1	0	1	2	4	2	4	1	3	1	2	1	3	4	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:149838001G>A	uc010zbu.1	+	14	1863	c.1495G>A	c.(1495-1497)GAC>AAC	p.D499N	KIF5C_uc002tws.1_RNA|KIF5C_uc002twt.2_Missense_Mutation_p.D51N	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	499					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		TGTCAATTATGACCAGAAATC	0.532													6	7					0	0	0	0	A	149838001	A	A	149838001	3	1	127	1	0	0	0	0	1	0	0	0	8346	1290	45	2	1471	2	KIF5C	2	149838001	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	43339643	149838001	93361372	21	22503											
MARCH7	64844	broad.mit.edu	37	chr2	160615841	160615841	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacatagagctcatgcaaatGaacaagttagtatattttgc	15	13	7	6	0	1	2	1	1	0	1	1	2	1	2	0	0	5	4	0	0	8	7			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:160615841G>A	uc002uax.2	+	7	2010	c.1888G>A	c.(1888-1890)GAA>AAA	p.E630K	MARCH7_uc010foq.2_Missense_Mutation_p.E630K|MARCH7_uc010zcn.1_Missense_Mutation_p.E574K|MARCH7_uc010for.2_Missense_Mutation_p.E592K|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	630							ligase activity|zinc ion binding				0						TCATGCAAATGAACAAGTTAG	0.353													38	57					0	0	0	0	A	160615841	A	A	160615841	3	1	127	1	0	0	0	0	1	0	0	0	9359	1291	45	2	1910	2	MARCH7	2	160615841	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	10777840	160615841	82583532	22	22504											
PDE11A	50940	broad.mit.edu	37	chr2	178592823	178592823	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggagagcagctgtgatcatGgcatcaacgtcgagagaaaa	14	6	13	8	3	2	3	2	1	0	2	3	6	2	3	0	2	3	3	0	2	3	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:178592823G>A	uc002ulq.2	-	11	2184	c.1866C>T	c.(1864-1866)GCC>GCT	p.A622A	PDE11A_uc002ulp.2_Silent_p.A178A|PDE11A_uc002ulr.2_Silent_p.A372A|PDE11A_uc002uls.1_Silent_p.A264A|PDE11A_uc002ult.1_Silent_p.A372A|PDE11A_uc002ulu.1_Silent_p.A264A	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	622					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CTGTGATCATGGCATCAACGT	0.443									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				23	38					0	0	0	0	A	178592823	A	A	178592823	2	1	127	1	0	0	0	0	0	0	0	1	11685	1335	47	4		4	PDE11A	2	178592823	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	17976982	178592823	64606550	23	22505											
TTN	7273	broad.mit.edu	37	chr2	179529438	179529439	+	Missense_Mutation	DNP	GG	AT	AT																															cacaagcgttttcttttcagGgacaatttcttggagagctt																										TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:179529438_179529439GG>AT	uc010zfk.1	-	12	1130_1131	c.582_583CC>AT	c.(580-585)GTCCCT>GTATCT	p.P195S	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTTTCAGGGACAATTTCTT	0.381													9	56					0	0	0	0	AT	179529439	AT	AT	179529438	3	1	127	1	0	0	0	0	1	0	0	0	16803	1247	43	4		4	TTN	2	179529438	Missense_Mutation	DNP	GG	TCGA-CR-6480-01A-11D-1870-08	936615	179529438	63669935	24	22506											
RPE	6120	broad.mit.edu	37	chr2	210867428	210867428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccgtccatcctcaacagcGacctggccaatttaggggcc	8	7	10	16	2	1	0	1	0	0	0	3	1	3	0	6	3	2	0	6	3	3	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr2:210867428G>A	uc002vdn.2	+	1	48	c.43G>A	c.(43-45)GAC>AAC	p.D15N	RPE_uc002vdm.2_Missense_Mutation_p.D15N|RPE_uc002vdo.2_5'UTR|RPE_uc010zjf.1_Missense_Mutation_p.D15N|RPE_uc002vdp.2_5'UTR|RPE_uc010fup.2_5'UTR|RPE_uc002vdq.2_5'Flank	NM_199229	NP_954699	Q96AT9	RPE_HUMAN	ribulose-5-phosphate-3-epimerase isoform 1	15					pentose-phosphate shunt	cytosol	metal ion binding|protein homodimerization activity|ribulose-phosphate 3-epimerase activity				0				Epithelial(149;0.00241)|Lung(261;0.041)|all cancers(144;0.0429)|LUSC - Lung squamous cell carcinoma(261;0.0431)		CCTCAACAGCGACCTGGCCAA	0.617													16	34					0	0	0	0	A	210867428	A	A	210867428	3	1	127	1	0	0	0	0	1	0	0	0	13609	1058	37	1	45	1	RPE	2	210867428	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	31337990	210867428	32331945	25	22507											
SETD5	55209	broad.mit.edu	37	chr3	9476528	9476528	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggaatgagcagggggaaggTtattagacttcatcggcgga	11	8	17	5	2	1	2	1	1	0	1	2	5	1	5	0	6	1	2	0	6	4	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:9476528T>G	uc003brt.2	+	6	785	c.350T>G	c.(349-351)GTT>GGT	p.V117G	SETD5_uc003brs.1_Missense_Mutation_p.V98G|SETD5_uc003bru.2_Missense_Mutation_p.V6G|SETD5_uc003brv.2_Missense_Mutation_p.V6G	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	117										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGGGGGAAGGTTATTAGACTT	0.438													9	31					0	0	0	0	G	9476528	G	G	9476528	3	3	127	1	0	0	0	0	1	0	0	0	14199	1725	60	5	364	5	SETD5	3	9476528	Missense_Mutation	SNP	T	TCGA-CR-6480-01A-11D-1870-08		9476528	188545902	26	22508											
CAMK1	8536	broad.mit.edu	37	chr3	9801205	9801205	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggcaaagttcttcttgatCtgctcactcaccgactggtg	7	14	9	11	1	5	1	2	1	3	0	5	2	5	1	1	2	1	3	1	2	1	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:9801205C>A	uc003bst.2	-	10	1057	c.879G>T	c.(877-879)CAG>CAT	p.Q293H	OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|CAMK1_uc003bsu.2_Intron|CAMK1_uc003bss.2_Missense_Mutation_p.Q67H|uc003bsv.1_5'Flank	NM_003656	NP_003647	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	293	Autoinhibitory domain (By similarity).				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|skin(1)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		TCTTCTTGATCTGCTCACTCA	0.527													7	240					5.18039e-06	5.34028e-06	1	0	A	9801205	A	A	9801205	3	1	127	1	0	0	0	0	1	0	0	0	2608	912	32	2	245	2	CAMK1	3	9801205	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	324677	9801205	188221225	27	22509											
WDR82	80335	broad.mit.edu	37	chr3	52292653	52292653	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caacacagctacttttatacCgctctctccattccagacat	11	12	3	15	1	1	1	0	0	1	1	4	1	3	1	3	0	4	2	3	0	4	5			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:52292653C>A	uc003ddl.2	-	8	1093	c.811G>T	c.(811-813)GGT>TGT	p.G271C	WDR82_uc003ddk.2_Missense_Mutation_p.G196C	NM_025222	NP_079498	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	271	WD 5.				histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding				0				BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		ACTTTTATACCGCTCTCTCCA	0.448													8	48					0.00307968	0.00311701	1	0	A	52292653	A	A	52292653	3	1	127	1	0	0	0	0	1	0	0	0	17399	652	23	3	138	3	WDR82	3	52292653	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	42491448	52292653	145729777	28	22510											
KIAA1407	57577	broad.mit.edu	37	chr3	113684007	113684007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttacactaatctggctcattCgttcaccagacttgtcttac	9	15	5	12	1	4	1	2	0	2	1	5	1	4	1	1	1	2	2	1	1	3	6			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:113684007C>T	uc003eax.2	-	17	2953	c.2806G>A	c.(2806-2808)GAA>AAA	p.E936K		NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	936										ovary(2)	2						CTGGCTCATTCGTTCACCAGA	0.438													20	111					0	0	0	0	T	113684007	T	T	113684007	3	4	127	1	0	0	0	0	1	0	0	0	8268	893	31	1	8	1	KIAA1407	3	113684007	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	61391354	113684007	84338423	29	22511											
COX17	10063	broad.mit.edu	37	chr3	119396148	119396148	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagggtttgagtcaaccaGacccggcatctttcgcgcca	8	8	12	13	3	2	2	1	1	1	1	3	2	2	2	3	3	1	3	3	3	1	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:119396148G>C	uc003ecz.1	-	1	96	c.10C>G	c.(10-12)CTG>GTG	p.L4V		NM_005694	NP_005685	Q14061	COX17_HUMAN	COX17 homolog, cytochrome c oxidase assembly	4	Ala/Pro-rich.				copper ion transport|generation of precursor metabolites and energy	mitochondrial intermembrane space	copper chaperone activity				0				GBM - Glioblastoma multiforme(114;0.227)		GAGTCAACCAGACCCGGCATC	0.617													6	21					0	0	0	0	C	119396148	C	C	119396148	3	2	127	1	0	0	0	0	1	0	0	0	3781	933	33	2	189	2	COX17	3	119396148	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	5712141	119396148	78626282	30	22512											
SEMA5B	54437	broad.mit.edu	37	chr3	122629104	122629104	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtctgctgcaatgggtaGaagttggctctgtcatcagg	7	13	14	7	0	4	1	2	0	2	1	4	1	4	1	0	4	2	5	0	4	3	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:122629104G>A	uc003efz.1	-	23	3646	c.3342C>T	c.(3340-3342)TTC>TTT	p.F1114F	SEMA5B_uc011bju.1_Silent_p.F1020F|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003efy.1_Silent_p.F92F	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	1114	Cytoplasmic (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		GCAATGGGTAGAAGTTGGCTC	0.537													41	129					0	0	0	0	A	122629104	A	A	122629104	2	1	127	1	0	0	0	0	0	0	0	1	14103	933	33	2		2	SEMA5B	3	122629104	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	3232956	122629104	75393326	31	22513											
KALRN	8997	broad.mit.edu	37	chr3	124066089	124066089	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggccctgcagaagaggcatGatgactttgaagaggtggct	10	8	16	7	0	0	6	0	3	0	3	0	6	0	6	1	4	1	3	1	4	2	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:124066089G>A	uc003ehg.2	+	10	1868	c.1741G>A	c.(1741-1743)GAT>AAT	p.D581N	KALRN_uc010hrv.1_Missense_Mutation_p.D581N|KALRN_uc003ehf.1_Missense_Mutation_p.D581N|KALRN_uc011bjy.1_Missense_Mutation_p.D581N	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	581	Spectrin 3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GAAGAGGCATGATGACTTTGA	0.413													26	145					0	0	0	0	A	124066089	A	A	124066089	3	1	127	1	0	0	0	0	1	0	0	0	8014	1290	45	2	1779	2	KALRN	3	124066089	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	1436985	124066089	73956341	32	22514											
PEX5L	51555	broad.mit.edu	37	chr3	179597776	179597776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctctctgctcagcatccGtgctgatgaggtcagatcca	7	10	11	13	1	3	3	2	2	1	1	6	3	5	3	3	2	3	3	3	2	0	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:179597776G>A	uc003fki.1	-	5	576	c.446C>T	c.(445-447)ACG>ATG	p.T149M	PEX5L_uc011bqd.1_Missense_Mutation_p.T106M|PEX5L_uc011bqe.1_Translation_Start_Site|PEX5L_uc011bqf.1_Intron|PEX5L_uc003fkj.1_Missense_Mutation_p.T114M|PEX5L_uc010hxd.1_Missense_Mutation_p.T147M|PEX5L_uc011bqg.1_Missense_Mutation_p.T125M|PEX5L_uc011bqh.1_Missense_Mutation_p.T90M	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	149					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CTCAGCATCCGTGCTGATGAG	0.517													12	131					0	0	0	0	A	179597776	A	A	179597776	3	1	127	1	0	0	0	0	1	0	0	0	11804	1145	40	1	1478	1	PEX5L	3	179597776	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	55531687	179597776	18424654	33	22515											
LMLN	89782	broad.mit.edu	37	chr3	197751552	197751552	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttaagaactatggcgctGaaaagtatggacctcattcc	12	13	8	8	1	1	2	1	1	0	1	2	3	2	3	2	2	1	2	2	2	6	6			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr3:197751552G>A	uc011buo.1	+	14	1571	c.1549G>A	c.(1549-1551)GAA>AAA	p.E517K	LMLN_uc003fyt.2_Missense_Mutation_p.E502K|LMLN_uc010iar.2_Missense_Mutation_p.E554K|LMLN_uc010ias.2_Missense_Mutation_p.E465K|LMLN_uc003fyu.2_Missense_Mutation_p.E314K	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	517					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CTATGGCGCTGAAAAGTATGG	0.393													21	92					0	0	0	0	A	197751552	A	A	197751552	3	1	127	1	0	0	0	0	1	0	0	0	8889	1291	45	2	1718	2	LMLN	3	197751552	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	18153776	197751552	270878	34	22516											
MAEA	10296	broad.mit.edu	37	chr4	1326563	1326563	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacatgcaagaaagcacttCagccaagcagaagggagcca	17	3	11	10	0	1	3	1	0	0	3	1	4	1	4	2	1	5	3	2	1	4	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:1326563C>A	uc003gda.2	+	6	705	c.675C>A	c.(673-675)TTC>TTA	p.F225L	MAEA_uc003gdb.2_Missense_Mutation_p.F184L|MAEA_uc011bvb.1_Missense_Mutation_p.F157L|MAEA_uc003gdc.2_Missense_Mutation_p.Q159K|MAEA_uc003gdd.2_RNA|MAEA_uc011bvc.1_Missense_Mutation_p.F224L|MAEA_uc011bvd.1_Missense_Mutation_p.F177L|MAEA_uc010ibt.2_Intron|MAEA_uc010ibu.2_RNA	NM_001017405	NP_001017405	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher isoform 1	225					cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(23;0.0201)			GAAAGCACTTCAGCCAAGCAG	0.428													10	26					3.07112e-06	3.18557e-06	1	0	A	1326563	A	A	1326563	3	1	127	1	0	0	0	0	1	0	0	0	9204	825	29	2	697	2	MAEA	4	1326563	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08		1326563	189827713	35	22517											
PCDH7	5099	broad.mit.edu	37	chr4	30723353	30723353	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccccagtgtcagatgatcttCgacgagaacgagtgcttcct	9	10	10	12	3	2	3	1	1	1	2	4	6	3	3	3	0	2	1	3	0	1	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:30723353C>T	uc003gsk.1	+	1	1317	c.309C>T	c.(307-309)TTC>TTT	p.F103F	PCDH7_uc011bxw.1_Silent_p.F103F|PCDH7_uc011bxx.1_Silent_p.F103F	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	103	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						AGATGATCTTCGACGAGAACG	0.602													11	10					0	0	0	0	T	30723353	T	T	30723353	2	4	127	1	0	0	0	0	0	0	0	1	11570	883	31	1		1	PCDH7	4	30723353	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08	29396790	30723353	160430923	36	22518											
FRAS1	80144	broad.mit.edu	37	chr4	79403092	79403092	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttcccagctctcggaaggtgGaatttgggcctggtgtcatt	6	13	13	9	1	2	0	1	0	1	0	4	2	3	2	2	5	1	1	2	5	2	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:79403092G>A	uc003hlb.2	+	57	9018	c.8578G>A	c.(8578-8580)GAA>AAA	p.E2860K		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2855	Calx-beta 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TCGGAAGGTGGAATTTGGGCC	0.522													50	43					0	0	0	0	A	79403092	A	A	79403092	3	1	127	1	0	0	0	0	1	0	0	0	6076	1175	41	2	8879	2	FRAS1	4	79403092	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	48679739	79403092	111751184	37	22519											
AFF1	4299	broad.mit.edu	37	chr4	88047256	88047256	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatgtttcactccaggccctCcaggccctcctcacagtcct	6	10	7	18	0	2	0	2	0	0	0	6	1	6	0	6	2	0	1	6	2	0	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:88047256C>T	uc003hqj.3	+	13	2965	c.2558C>T	c.(2557-2559)TCC>TTC	p.S853F	AFF1_uc011ccz.1_Missense_Mutation_p.S860F|AFF1_uc003hqk.3_Missense_Mutation_p.S853F|AFF1_uc011cda.1_Missense_Mutation_p.S491F	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	853						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TCCAGGCCCTCCAGGCCCTCC	0.537													50	69					0	0	0	0	T	88047256	T	T	88047256	3	4	127	1	0	0	0	0	1	0	0	0	356	855	30	2	2650	2	AFF1	4	88047256	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	8644164	88047256	103107020	38	22520			2	28		2	2	22	C		8.886209e-05
AFF1	4299	broad.mit.edu	37	chr4	88047277	88047277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggccctcctcacagtcctCaaagaaggaaatgctccccc	11	6	7	17	0	2	1	2	0	0	1	5	2	5	2	5	2	1	1	5	2	3	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:88047277C>T	uc003hqj.3	+	13	2986	c.2579C>T	c.(2578-2580)TCA>TTA	p.S860L	AFF1_uc011ccz.1_Missense_Mutation_p.S867L|AFF1_uc003hqk.3_Missense_Mutation_p.S860L|AFF1_uc011cda.1_Missense_Mutation_p.S498L	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	860						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TCACAGTCCTCAAAGAAGGAA	0.552													41	59					0	0	0	0	T	88047277	T	T	88047277	3	4	127	1	0	0	0	0	1	0	0	0	356	838	29	2	2671	2	AFF1	4	88047277	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	21	88047277	103106999	39	22521			2	28		2	2	22	C		8.886209e-05
DDX60L	91351	broad.mit.edu	37	chr4	169383027	169383027	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggccttcctctgaaactatCagaaaatacgggtaatgctg	13	10	9	9	1	2	2	1	1	1	1	3	2	3	2	2	2	3	2	2	2	6	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:169383027C>T	uc003irq.3	-	5	650	c.429G>A	c.(427-429)CTG>CTA	p.L143L	DDX60L_uc003irr.1_Silent_p.L143L	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	143							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CTGAAACTATCAGAAAATACG	0.378													4	13					0	0	0	0	T	169383027	T	T	169383027	2	4	127	1	0	0	0	0	0	0	0	1	4396	813	29	2		2	DDX60L	4	169383027	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08	81335750	169383027	21771249	40	22522											
DDX60L	91351	broad.mit.edu	37	chr4	169383170	169383170	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaaagaagttcaggaaaatCaaaatatgcatattcagcat	19	10	7	5	0	3	2	3	1	0	1	3	3	3	3	0	1	2	3	0	1	8	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr4:169383170C>T	uc003irq.3	-	5	507	c.286G>A	c.(286-288)GAT>AAT	p.D96N	DDX60L_uc003irr.1_Missense_Mutation_p.D96N	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	96							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TCAGGAAAATCAAAATATGCA	0.348													7	10					0	0	0	0	T	169383170	T	T	169383170	3	4	127	1	0	0	0	0	1	0	0	0	4396	826	29	2	4970	2	DDX60L	4	169383170	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	143	169383170	21771106	41	22523											
LIFR	3977	broad.mit.edu	37	chr5	38504091	38504091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcttacctgctcttgtactGaattagatttcttaatttca	10	19	4	8	0	4	2	1	1	3	1	4	2	4	2	1	0	3	2	1	0	5	7			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:38504091G>A	uc010ive.1	-	10	1756	c.1424C>T	c.(1423-1425)TCA>TTA	p.S475L	LIFR_uc003jli.2_Missense_Mutation_p.S475L	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	475	Extracellular (Potential).|Fibronectin type-III 3.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					CTCTTGTACTGAATTAGATTT	0.284			T	PLAG1	salivary adenoma								33	53					0	0	0	0	A	38504091	A	A	38504091	3	1	127	1	0	0	0	0	1	0	0	0	8821	1294	45	2	1913	2	LIFR	5	38504091	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08		38504091	142411169	42	22524											
DMXL1	1657	broad.mit.edu	37	chr5	118533530	118533530	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagttcttctccgacgacttGaaatccatggtgggccacct	9	11	9	12	2	2	1	0	1	2	0	4	3	3	1	4	2	0	1	4	2	2	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:118533530G>A	uc003ksd.2	+	32	7805	c.7624G>A	c.(7624-7626)GAA>AAA	p.E2542K	DMXL1_uc010jcl.1_Missense_Mutation_p.E2542K	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2542										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CCGACGACTTGAAATCCATGG	0.443													70	73					0	0	0	0	A	118533530	A	A	118533530	3	1	127	1	0	0	0	0	1	0	0	0	4616	1291	45	2	7750	2	DMXL1	5	118533530	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	80029439	118533530	62381730	43	22525											
GFRA3	2676	broad.mit.edu	37	chr5	137599972	137599972	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggctgcgggcacggtgaacGgtccaatagatgtccaagca	11	6	14	10	3	0	2	0	1	0	1	2	2	2	2	2	4	3	3	2	4	4	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:137599972G>A	uc003lcn.2	-	2	497	c.357C>T	c.(355-357)ACC>ACT	p.T119T	GFRA3_uc003lco.2_Silent_p.T119T	NM_001496	NP_001487	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3 preproprotein	119					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CACGGTGAACGGTCCAATAGA	0.552													25	49					0	0	0	0	A	137599972	A	A	137599972	2	1	127	1	0	0	0	0	0	0	0	1	6386	1103	39	1		1	GFRA3	5	137599972	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	19066442	137599972	43315288	44	22526											
ECSCR	641700	broad.mit.edu	37	chr5	138842247	138842247	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagctgcatggctcctgcGgtgcccatgtcagctgggta	6	9	13	13	1	1	0	1	0	0	0	2	0	2	0	2	3	5	5	2	3	1	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:138842247G>A	uc011cze.1	-	1	74	c.9C>T	c.(7-9)ACC>ACT	p.T3T		NM_001077693	NP_001071161	Q19T08	ECSCR_HUMAN	endothelial cell-specific chemotaxis regulator	3					angiogenesis|cell differentiation|chemotaxis	integral to membrane|plasma membrane					0						TGGCTCCTGCGGTGCCCATGT	0.632													5	7					0	0	0	0	A	138842247	A	A	138842247	2	1	127	1	0	0	0	0	0	0	0	1	4921	1103	39	1		1	ECSCR	5	138842247	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	1242275	138842247	42073013	45	22527											
PCDHA11	56138	broad.mit.edu	37	chr5	140250408	140250408	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaggctggcagcgcgggaGgcgcagttaacaagctagta	10	6	15	10	3	1	0	1	0	0	0	1	1	1	1	0	4	3	6	0	4	4	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:140250408G>A	uc003lia.2	+	1	2578	c.1720G>A	c.(1720-1722)GGC>AGC	p.G574S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.G574S	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	574	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCGCGGGAGGCGCAGTTAA	0.667													64	73					0	0	0	0	A	140250408	A	A	140250408	3	1	127	1	0	0	0	0	1	0	0	0	11575	1000	35	4	1722	4	PCDHA11	5	140250408	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	1408161	140250408	40664852	46	22528											
C5orf25	375484	broad.mit.edu	37	chr5	175740719	175740719	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aactctgcctgggcgagtccTtttcctgcgttatgtcgttc	4	15	10	12	3	1	0	0	0	1	0	5	1	3	0	3	1	3	2	3	1	2	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr5:175740719T>C	uc003mds.3	+	7	2110	c.1703T>C	c.(1702-1704)CTT>CCT	p.L568P	C5orf25_uc003mdt.3_Missense_Mutation_p.L153P|C5orf25_uc003mdr.3_RNA|C5orf25_uc003mdv.2_Missense_Mutation_p.L29P			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	568											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		GGGCGAGTCCTTTTCCTGCGT	0.488													4	314					0	0	0	0	C	175740719	C	C	175740719	3	2	127	1	0	0	0	0	1	0	0	0	2298	1609	56	5	472	5	C5orf25	5	175740719	Missense_Mutation	SNP	T	TCGA-CR-6480-01A-11D-1870-08	35490311	175740719	5174541	47	22529											
SLC35B3	51000	broad.mit.edu	37	chr6	8421006	8421006	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagcgagggtaaaccatatCaggccaaggctcatacatat	14	8	9	10	1	3	0	3	0	0	0	3	1	3	0	2	3	3	2	2	3	6	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr6:8421006C>T	uc010joe.2	-	6	796	c.630G>A	c.(628-630)CTG>CTA	p.L210L	SLC35B3_uc003mya.2_Silent_p.L178L|SLC35B3_uc003myc.2_RNA|SLC35B3_uc003myb.2_Silent_p.L210L|SLC35B3_uc011did.1_Silent_p.L210L|SLC35B3_uc003myd.2_RNA	NM_001142541	NP_001136013	Q9H1N7	S35B3_HUMAN	solute carrier family 35, member B3	210	Helical; (Potential).				transmembrane transport	Golgi membrane|integral to membrane					0	Ovarian(93;0.0569)					TAAACCATATCAGGCCAAGGC	0.388													37	111					0	0	0	0	T	8421006	T	T	8421006	2	4	127	1	0	0	0	0	0	0	0	1	14641	813	29	2		2	SLC35B3	6	8421006	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08		8421006	162694061	48	22530											
NHLRC1	378884	broad.mit.edu	37	chr6	18122141	18122141	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagggaccctgcctccgcatCagttaccacaatcccattct	9	9	6	17	1	2	0	1	0	1	0	4	1	4	1	5	1	2	2	5	1	2	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr6:18122141C>G	uc003ncl.1	-	1	711	c.697G>C	c.(697-699)GAT>CAT	p.D233H		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	233	NHL 3.		D -> A (in EPM2).		proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			GCCTCCGCATCAGTTACCACA	0.542													12	38					0	0	0	0	G	18122141	G	G	18122141	3	3	127	1	0	0	0	0	1	0	0	0	10459	826	29	2	494	2	NHLRC1	6	18122141	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	9701135	18122141	152992926	49	22531											
FTSJD2	23070	broad.mit.edu	37	chr6	37429416	37429416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catggcgctgtccattgtccGgacaggtgacacttcctcag	7	10	11	13	2	1	1	1	1	0	0	4	2	4	2	3	3	0	1	3	3	0	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr6:37429416G>A	uc003ons.2	+	11	1440	c.1187G>A	c.(1186-1188)CGG>CAG	p.R396Q	FTSJD2_uc010jwu.2_Missense_Mutation_p.R340Q	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	396					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TCCATTGTCCGGACAGGTGAC	0.537													3	74					0	0	0	0	A	37429416	A	A	37429416	3	1	127	1	0	0	0	0	1	0	0	0	6125	1116	39	1	1225	1	FTSJD2	6	37429416	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	19307275	37429416	133685651	50	22532											
DST	667	broad.mit.edu	37	chr6	56496810	56496810	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcgaacttcagagatgtaGagattataaactgattcctc	13	14	7	7	1	1	3	1	1	0	2	4	6	2	3	1	0	2	1	1	0	5	6			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr6:56496810G>C	uc003pdf.2	-	28	3763	c.3735C>G	c.(3733-3735)CTC>CTG	p.L1245L	DST_uc003pcz.3_Silent_p.L1067L|DST_uc011dxj.1_Silent_p.L1096L|DST_uc011dxk.1_Silent_p.L1107L|DST_uc003pcy.3_Silent_p.L741L|DST_uc003pdb.2_Silent_p.L741L|DST_uc003pdc.3_Silent_p.L741L|DST_uc003pdd.3_Silent_p.L741L	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1067					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CAGAGATGTAGAGATTATAAA	0.348													17	38					0	0	0	0	C	56496810	C	C	56496810	2	2	127	1	0	0	0	0	0	0	0	1	4805	929	33	2		2	DST	6	56496810	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	19067394	56496810	114618257	51	22533											
ACTB	60	broad.mit.edu	37	chr7	5568921	5568921	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attttctccatgtcgtcccaGttggtgacgatgccgtgctc	5	14	10	12	3	1	1	0	1	1	0	5	2	2	1	3	1	2	2	3	1	0	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:5568921G>C	uc003sos.3	-	2	270	c.234C>G	c.(232-234)AAC>AAG	p.N78K	ACTB_uc003sor.3_5'UTR|ACTB_uc003sot.3_Missense_Mutation_p.N78K|ACTB_uc003soq.3_5'UTR|ACTB_uc010ksy.2_Intron	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	78					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TGTCGTCCCAGTTGGTGACGA	0.607													33	48					0	0	0	0	C	5568921	C	C	5568921	3	2	127	1	0	0	0	0	1	0	0	0	193	1020	36	4	909	4	ACTB	7	5568921	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08		5568921	153569742	52	22534											
ICA1	3382	broad.mit.edu	37	chr7	8196806	8196806	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctctcatggatggctgccatAgtgtgagaagttttctccca	8	13	10	10	0	2	1	1	1	2	1	4	3	2	2	2	2	1	2	2	2	2	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:8196806A>T	uc003srm.2	-	8	811	c.744T>A	c.(742-744)ACT>ACA	p.T248T	ICA1_uc010ktr.2_Silent_p.T248T|ICA1_uc003srl.2_Silent_p.T236T|ICA1_uc003srn.3_Silent_p.T174T|ICA1_uc003srp.3_Silent_p.T247T|ICA1_uc010kts.2_Intron|ICA1_uc003srq.2_Silent_p.T248T|ICA1_uc003srr.2_Silent_p.T247T|ICA1_uc003sro.3_Silent_p.T248T|ICA1_uc011jxg.1_Silent_p.T248T|ICA1_uc003srs.1_Silent_p.T248T	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	248	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TGGCTGCCATAGTGTGAGAAG	0.398													6	88					0	0	0	0	T	8196806	T	T	8196806	2	4	127	1	0	0	0	0	0	0	0	1	7516	407	15	5		5	ICA1	7	8196806	Silent	SNP	A	TCGA-CR-6480-01A-11D-1870-08	2627885	8196806	150941857	53	22535											
WBSCR17	64409	broad.mit.edu	37	chr7	70597882	70597882	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccaagtgccggcccatcGcggtgcgcagcggagacgcc	6	4	16	15	6	0	1	0	0	0	1	1	2	0	1	4	4	3	1	4	4	1	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:70597882G>A	uc003tvy.2	+	1	94	c.94G>A	c.(94-96)GCG>ACG	p.A32T		NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	32	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CCGGCCCATCGCGGTGCGCAG	0.637													9	16					0	0	0	0	A	70597882	A	A	70597882	3	1	127	1	0	0	0	0	1	0	0	0	17332	1087	38	1	96	1	WBSCR17	7	70597882	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	62401076	70597882	88540781	54	22536											
NAPEPLD	222236	broad.mit.edu	37	chr7	102743916	102743916	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tatttaggtatcttgattctCcatgcttcaagacaaaaaaa	15	14	5	7	0	3	2	1	1	2	1	4	2	3	2	1	1	1	2	1	1	7	7			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:102743916C>T	uc003vbc.2	-	5	1470	c.1142G>A	c.(1141-1143)GGA>GAA	p.G381E	NAPEPLD_uc003vbd.2_Missense_Mutation_p.G381E|NAPEPLD_uc011klj.1_Missense_Mutation_p.G454E|NAPEPLD_uc003vbe.2_RNA	NM_198990	NP_945341	Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	381					phospholipid catabolic process	membrane	metal ion binding			skin(1)	1						TCTTGATTCTCCATGCTTCAA	0.348													29	59					0	0	0	0	T	102743916	T	T	102743916	3	4	127	1	0	0	0	0	1	0	0	0	10216	855	30	2	43	2	NAPEPLD	7	102743916	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	32146034	102743916	56394747	55	22537											
HBP1	26959	broad.mit.edu	37	chr7	106826251	106826251	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgctttattttagatcatCtcctgtacacatcatagcca	10	16	5	10	0	3	1	2	0	1	1	4	1	3	1	2	0	3	3	2	0	4	7			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:106826251C>G	uc003vdy.2	+	4	590	c.404C>G	c.(403-405)TCT>TGT	p.S135C	HBP1_uc011klv.1_Missense_Mutation_p.S145C|HBP1_uc003vdz.2_Missense_Mutation_p.S135C|HBP1_uc003vea.2_Missense_Mutation_p.S135C|HBP1_uc003veb.1_Missense_Mutation_p.S135C	NM_012257	NP_036389	O60381	HBP1_HUMAN	HMG-box transcription factor 1	135					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			skin(1)	1						TTTAGATCATCTCCTGTACAC	0.393													54	85					0	0	0	0	G	106826251	G	G	106826251	3	3	127	1	0	0	0	0	1	0	0	0	7024	913	32	2	414	2	HBP1	7	106826251	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	4082335	106826251	52312412	56	22538											
NRCAM	4897	broad.mit.edu	37	chr7	107880487	107880487	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagataagcgcttcttttTcggcattattttaagctgca	9	15	8	9	3	1	1	0	0	1	1	2	1	1	1	0	1	3	5	0	1	3	7			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:107880487T>C	uc003vfb.2	-	4	493	c.22A>G	c.(22-24)AAA>GAA	p.K8E	NRCAM_uc003vfc.2_Missense_Mutation_p.K8E|NRCAM_uc011kmk.1_Missense_Mutation_p.K3E|NRCAM_uc003vfd.2_Missense_Mutation_p.K3E|NRCAM_uc003vfe.2_Missense_Mutation_p.K3E	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	8					angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						CGCTTCTTTTTCGGCATTATT	0.418													45	69					0	0	0	0	C	107880487	C	C	107880487	3	2	127	1	0	0	0	0	1	0	0	0	10698	1792	62	5	4042	5	NRCAM	7	107880487	Missense_Mutation	SNP	T	TCGA-CR-6480-01A-11D-1870-08	1054236	107880487	51258176	57	22539											
POT1	25913	broad.mit.edu	37	chr7	124481048	124481048	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctatcaaaagtagacattCatttgaaagcgggagaatac	16	11	8	6	1	3	3	2	1	1	2	3	4	3	3	0	1	2	1	0	1	7	6			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:124481048C>T	uc003vlm.2	-	14	1949	c.1348G>A	c.(1348-1350)GAA>AAA	p.E450K	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.E319K|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	450					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						AGTAGACATTCATTTGAAAGC	0.269													30	77					0	0	0	0	T	124481048	T	T	124481048	3	4	127	1	0	0	0	0	1	0	0	0	12315	835	29	2	580	2	POT1	7	124481048	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	16600561	124481048	34657615	58	22540											
FAM71F1	84691	broad.mit.edu	37	chr7	128359080	128359081	+	Missense_Mutation	DNP	TC	AG	AG																															accaccaaagaccctaggatTcttgtcacgcactgcctggt																										TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:128359080_128359081TC>AG	uc003vno.1	+	3	683_684	c.630_631TC>AG	c.(628-633)ATTCTT>ATAGTT	p.L211V	FAM71F1_uc010llo.1_Missense_Mutation_p.L112V|FAM71F1_uc011koq.1_Missense_Mutation_p.L103V|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.L112V|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.L211V	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	211										skin(1)	1						ACCCTAGGATTCTTGTCACGCA	0.54													5	108					0	0	0	0	AG	128359081	AG	AG	128359080	3	1	127	1	0	0	0	0	1	0	0	0	5644	1771	62	5	640	5	FAM71F1	7	128359080	Missense_Mutation	DNP	TC	TCGA-CR-6480-01A-11D-1870-08	3878032	128359080	30779583	59	22541											
DENND2A	27147	broad.mit.edu	37	chr7	140266910	140266910	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagggaactgttgggtgagTtctggcacgtaggcagcccc	8	8	16	9	1	1	2	0	1	1	1	1	3	1	3	2	4	2	5	2	4	2	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr7:140266910T>A	uc010lnj.2	-	7	1900	c.1755A>T	c.(1753-1755)GAA>GAT	p.E585D	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.E585D|DENND2A_uc003vvw.2_Missense_Mutation_p.E585D|DENND2A_uc003vvx.2_Missense_Mutation_p.E585D	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	585	UDENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GTTGGGTGAGTTCTGGCACGT	0.562													6	5					0	0	0	0	A	140266910	A	A	140266910	3	1	127	1	0	0	0	0	1	0	0	0	4451	1722	60	5	1322	5	DENND2A	7	140266910	Missense_Mutation	SNP	T	TCGA-CR-6480-01A-11D-1870-08	11907830	140266910	18871753	60	22542											
UNC5D	137970	broad.mit.edu	37	chr8	35616853	35616853	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tataggaagtggtttcagatGaaaggcatcaaggtggacag	14	9	14	4	0	2	2	2	1	0	1	2	4	2	4	0	5	0	2	0	5	5	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr8:35616853G>A	uc003xjr.1	+	14	2507	c.2179G>A	c.(2179-2181)GAA>AAA	p.E727K	UNC5D_uc003xjs.1_Missense_Mutation_p.E722K|UNC5D_uc003xju.1_Missense_Mutation_p.E303K	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	727	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GGTTTCAGATGAAAGGCATCA	0.378													37	70					0	0	0	0	A	35616853	A	A	35616853	3	1	127	1	0	0	0	0	1	0	0	0	17063	1291	45	2	2233	2	UNC5D	8	35616853	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08		35616853	110747169	61	22543											
RUNX1T1	862	broad.mit.edu	37	chr8	93027012	93027012	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgggtggtgagggggcgccaTtcaaggctgtaggagaatgg	8	8	20	5	1	1	2	1	1	0	1	1	3	1	2	1	7	0	2	1	7	3	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr8:93027012T>C	uc003yfd.2	-	3	347	c.263A>G	c.(262-264)AAT>AGT	p.N88S	RUNX1T1_uc003yfc.1_Missense_Mutation_p.N61S|RUNX1T1_uc003yfe.1_Missense_Mutation_p.N51S|RUNX1T1_uc010mao.2_Missense_Mutation_p.N61S|RUNX1T1_uc011lgi.1_Missense_Mutation_p.N99S|RUNX1T1_uc003yfh.1_Missense_Mutation_p.N51S|RUNX1T1_uc003yfb.1_Missense_Mutation_p.N51S|RUNX1T1_uc003yff.1_Missense_Mutation_p.N51S|RUNX1T1_uc003yfg.1_Missense_Mutation_p.N51S	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	88					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GGGGGCGCCATTCAAGGCTGT	0.517													3	46					0	0	0	0	C	93027012	C	C	93027012	3	2	127	1	0	0	0	0	1	0	0	0	13812	1493	52	5	1587	5	RUNX1T1	8	93027012	Missense_Mutation	SNP	T	TCGA-CR-6480-01A-11D-1870-08	57410159	93027012	53337010	62	22544											
PLEC	5339	broad.mit.edu	37	chr8	144992204	144992204	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgcagctggtgccttccaGgaacttctgcaagttcttgg	7	12	12	10	0	2	0	0	0	2	0	3	2	3	1	2	3	5	4	2	3	2	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr8:144992204G>A	uc003zaf.1	-	32	12366	c.12196C>T	c.(12196-12198)CTG>TTG	p.L4066L	PLEC_uc003zab.1_Silent_p.L3929L|PLEC_uc003zac.1_Silent_p.L3933L|PLEC_uc003zad.2_Silent_p.L3929L|PLEC_uc003zae.1_Silent_p.L3897L|PLEC_uc003zag.1_Silent_p.L3907L|PLEC_uc003zah.2_Silent_p.L3915L|PLEC_uc003zaj.2_Silent_p.L3956L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4066	Plectin 22.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTGCCTTCCAGGAACTTCTGC	0.642													7	8					0	0	0	0	A	144992204	A	A	144992204	2	1	127	1	0	0	0	0	0	0	0	1	12107	991	35	4		4	PLEC	8	144992204	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	51965192	144992204	1371818	63	22545											
KIAA0020	9933	broad.mit.edu	37	chr9	2829887	2829887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctgatgcttccgcatgccGcagcatcttcctcacgtggc	5	10	11	15	3	2	1	1	1	1	0	4	1	4	1	3	2	3	5	3	2	0	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:2829887G>A	uc003zhp.1	-	8	835	c.739C>T	c.(739-741)CGG>TGG	p.R247W	KIAA0020_uc010mhc.1_Missense_Mutation_p.R246W|KIAA0020_uc003zhq.1_Missense_Mutation_p.R246W	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein	247	Pumilio 3.|PUM-HD.					endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)		TCCGCATGCCGCAGCATCTTC	0.438													5	122					0	0	0	0	A	2829887	A	A	2829887	3	1	127	1	0	0	0	0	1	0	0	0	8191	1086	38	1	1251	1	KIAA0020	9	2829887	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08		2829887	138383544	64	22546											
KIAA2026	158358	broad.mit.edu	37	chr9	5968103	5968103	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgtaagacttgaatgcaaGagaatgaagaccttcacgct	14	11	9	7	1	1	5	1	2	0	3	1	6	1	5	1	0	1	3	1	0	5	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:5968103G>C	uc003zjq.3	-	3	2344	c.2128C>G	c.(2128-2130)CTT>GTT	p.L710V		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	710	Lys-rich.									ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTGAATGCAAGAGAATGAAGA	0.308													3	6					0	0	0	0	C	5968103	C	C	5968103	3	2	127	1	0	0	0	0	1	0	0	0	8309	942	33	2	4207	2	KIAA2026	9	5968103	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	3138216	5968103	135245328	65	22547											
KIAA2026	158358	broad.mit.edu	37	chr9	5968206	5968206	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccctcattttagttagtttGagtttcttgtggctctgtag	5	19	10	7	0	3	1	1	1	2	0	3	1	3	1	1	1	0	5	1	1	3	7			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:5968206G>A	uc003zjq.3	-	3	2241	c.2025C>T	c.(2023-2025)CTC>CTT	p.L675L		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	675	Lys-rich.									ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TAGTTAGTTTGAGTTTCTTGT	0.333													23	41					0	0	0	0	A	5968206	A	A	5968206	2	1	127	1	0	0	0	0	0	0	0	1	8309	1277	45	2		2	KIAA2026	9	5968206	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	103	5968206	135245225	66	22548											
PTPRD	5789	broad.mit.edu	37	chr9	8484233	8484233	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctggtgcagtctttgccGtgaccctgtgctgcagccca	5	11	11	14	1	2	1	0	1	2	0	2	1	2	1	3	1	5	3	3	1	0	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:8484233G>A	uc003zkk.2	-	29	4010	c.3299C>T	c.(3298-3300)ACG>ATG	p.T1100M	PTPRD_uc003zkp.2_Missense_Mutation_p.T689M|PTPRD_uc003zkq.2_Missense_Mutation_p.T689M|PTPRD_uc003zkr.2_Missense_Mutation_p.T684M|PTPRD_uc003zks.2_Missense_Mutation_p.T679M|PTPRD_uc003zkl.2_Missense_Mutation_p.T1091M|PTPRD_uc003zkm.2_Missense_Mutation_p.T1087M|PTPRD_uc003zkn.2_Missense_Mutation_p.T689M|PTPRD_uc003zko.2_Missense_Mutation_p.T686M	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1100	Fibronectin type-III 8.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AGTCTTTGCCGTGACCCTGTG	0.483										TSP Lung(15;0.13)			24	49					0	0	0	0	A	8484233	A	A	8484233	3	1	127	1	0	0	0	0	1	0	0	0	12864	1145	40	1	2572	1	PTPRD	9	8484233	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	2516027	8484233	132729198	67	22549											
DNAJA1	3301	broad.mit.edu	37	chr9	33030454	33030454	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttaggtagaggaggtaagaaAggagcagtagagtgctgtcc	13	8	16	4	0	0	3	0	0	0	3	1	5	1	5	1	4	2	5	1	4	5	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:33030454A>G	uc003zsd.1	+	5	615	c.432A>G	c.(430-432)AAA>AAG	p.K144K	DNAJA1_uc011lnt.1_5'UTR|DNAJA1_uc003zse.1_Silent_p.K144K	NM_001539	NP_001530	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	144	CR-type.				protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		GAGGTAAGAAAGGAGCAGTAG	0.353													11	8					0	0	0	0	G	33030454	G	G	33030454	2	3	127	1	0	0	0	0	0	0	0	1	4633	69	3	5		5	DNAJA1	9	33030454	Silent	SNP	A	TCGA-CR-6480-01A-11D-1870-08	24546221	33030454	108182977	68	22550											
RECK	8434	broad.mit.edu	37	chr9	36117110	36117110	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgacacagaccacatggAgcacaacaatctctgcactt	13	9	7	12	0	1	2	0	1	1	1	2	3	1	3	1	1	3	2	1	1	2	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:36117110A>G	uc003zyv.2	+	17	2275	c.2189A>G	c.(2188-2190)GAG>GGG	p.E730G	RECK_uc003zyw.2_Missense_Mutation_p.E602G|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	730	Kazal-like 2.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GACCACATGGAGCACAACAAT	0.453													5	52					0	0	0	0	G	36117110	G	G	36117110	3	3	127	1	0	0	0	0	1	0	0	0	13265	304	11	5	2255	5	RECK	9	36117110	Missense_Mutation	SNP	A	TCGA-CR-6480-01A-11D-1870-08	3086656	36117110	105096321	69	22551											
PTAR1	375743	broad.mit.edu	37	chr9	72338300	72338300	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataagatcagtgctgaattCaacttcttcttctagaagat	14	14	6	7	0	5	4	2	1	3	3	5	4	5	4	0	0	2	1	0	0	6	6			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:72338300C>G	uc004ahj.3	-	6	911	c.889G>C	c.(889-891)GAA>CAA	p.E297Q	PTAR1_uc004ahi.2_Missense_Mutation_p.E218Q	NM_001099666	NP_001093136	Q7Z6K3	PTAR1_HUMAN	protein prenyltransferase alpha subunit repeat	297	PFTA 5.				protein prenylation		protein prenyltransferase activity			central_nervous_system(1)	1						GTGCTGAATTCAACTTCTTCT	0.408													59	90					0	0	0	0	G	72338300	G	G	72338300	3	3	127	1	0	0	0	0	1	0	0	0	12786	835	29	2	331	2	PTAR1	9	72338300	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	36221190	72338300	68875131	70	22552											
FAM125B	89853	broad.mit.edu	37	chr9	129157913	129157913	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtaccaagaaatcatgactCatctcaacccacaacgcctt	15	8	4	14	1	3	2	3	1	1	1	4	2	3	2	3	0	3	1	3	0	5	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:129157913C>T	uc004bqh.1	+	6	680	c.599C>T	c.(598-600)TCA>TTA	p.S200L	FAM125B_uc004bqg.1_Missense_Mutation_p.S200L|FAM125B_uc011lzy.1_Missense_Mutation_p.S185L|FAM125B_uc010mxd.2_Missense_Mutation_p.S193L|FAM125B_uc011lzz.1_Missense_Mutation_p.S193L	NM_033446	NP_258257	Q9H7P6	F125B_HUMAN	hypothetical protein LOC89853 isoform 1	200					protein transport	late endosome membrane					0						AATCATGACTCATCTCAACCC	0.532													57	91					0	0	0	0	T	129157913	T	T	129157913	3	4	127	1	0	0	0	0	1	0	0	0	5456	838	29	2	621	2	FAM125B	9	129157913	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	56819613	129157913	12055518	71	22553											
COL5A1	1289	broad.mit.edu	37	chr9	137734077	137734077	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtgcccatcgtggacatCatgttcaatgacttcggtga	9	11	11	10	2	2	2	2	2	0	0	4	3	2	3	1	3	1	1	1	3	1	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr9:137734077C>T	uc004cfe.2	+	66	5827	c.5445C>T	c.(5443-5445)ATC>ATT	p.I1815I	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1815	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TCGTGGACATCATGTTCAATG	0.582													14	25					0	0	0	0	T	137734077	T	T	137734077	2	4	127	1	0	0	0	0	0	0	0	1	3711	816	29	2		2	COL5A1	9	137734077	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08	8576164	137734077	3479354	72	22554											
PRKCQ	5588	broad.mit.edu	37	chr10	6506278	6506278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctttaaagcctcttacgtcGctctggaaaggtcgaacttg	9	12	9	11	3	2	0	0	0	2	0	4	2	2	1	2	2	3	1	2	2	5	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:6506278G>A	uc001ijj.1	-	13	1517	c.1442C>T	c.(1441-1443)GCG>GTG	p.A481V	PRKCQ_uc009xim.1_Missense_Mutation_p.A481V|PRKCQ_uc001iji.1_Missense_Mutation_p.A514V|PRKCQ_uc009xin.1_Missense_Mutation_p.A445V|PRKCQ_uc010qax.1_Missense_Mutation_p.A356V	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	481	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						CTCTTACGTCGCTCTGGAAAG	0.448													88	275					0	0	0	0	A	6506278	A	A	6506278	3	1	127	1	0	0	0	0	1	0	0	0	12577	1087	38	1	702	1	PRKCQ	10	6506278	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08		6506278	129028469	73	22555											
PPYR1	5540	broad.mit.edu	37	chr10	47087415	47087415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggccactggctcaccaccGcaccatctacaccaccttcc	8	7	5	21	1	2	0	1	0	1	0	3	0	3	0	7	2	1	2	7	2	1	2	rs147108354		TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:47087415G>A	uc001jee.2	+	3	1051	c.632G>A	c.(631-633)CGC>CAC	p.R211H	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Missense_Mutation_p.R211H	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	211	Extracellular (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						GCTCACCACCGCACCATCTAC	0.582													5	177					0	0	0	0	A	47087415	A	A	47087415	3	1	127	1	0	0	0	0	1	0	0	0	12476	1087	38	1	634	1	PPYR1	10	47087415	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	40581137	47087415	88447332	74	22556											
ANK3	288	broad.mit.edu	37	chr10	61828403	61828403	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcattctcaccagtccttCtactgctccttttctcactg	5	17	3	16	0	4	0	3	0	3	0	8	0	6	0	3	0	2	1	3	0	1	6			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61828403C>G	uc001jky.2	-	37	12428	c.12236G>C	c.(12235-12237)AGA>ACA	p.R4079T	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	4079					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						ACCAGTCCTTCTACTGCTCCT	0.473													56	100					0	0	0	0	G	61828403	G	G	61828403	3	3	127	1	0	0	0	0	1	0	0	0	622	913	32	2	1238	2	ANK3	10	61828403	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	14740988	61828403	73706344	75	22557			3	29		8	8	3551	C		3.361318e-17
ANK3	288	broad.mit.edu	37	chr10	61829289	61829289	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgttgttattaaagttatCtttttgaaaatcatgttttt	10	23	6	2	0	2	1	1	1	1	0	2	1	2	1	0	0	0	5	0	0	6	9			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61829289C>G	uc001jky.2	-	37	11542	c.11350G>C	c.(11350-11352)GAT>CAT	p.D3784H	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3784					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTAAAGTTATCTTTTTGAAAA	0.343													64	96					0	0	0	0	G	61829289	G	G	61829289	3	3	127	1	0	0	0	0	1	0	0	0	622	913	32	2	2124	2	ANK3	10	61829289	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	886	61829289	73705458	76	22558			3	29		8	8	3551	C		3.361318e-17
ANK3	288	broad.mit.edu	37	chr10	61829440	61829440	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctccagggccttctttcttCatggtcatggtggatgcaga	6	14	11	10	0	5	1	2	0	3	1	6	2	5	2	2	4	1	1	2	4	0	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61829440C>T	uc001jky.2	-	37	11391	c.11199G>A	c.(11197-11199)ATG>ATA	p.M3733I	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3733					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CTTCTTTCTTCATGGTCATGG	0.428													106	151					0	0	0	0	T	61829440	T	T	61829440	3	4	127	1	0	0	0	0	1	0	0	0	622	826	29	2	2275	2	ANK3	10	61829440	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	151	61829440	73705307	77	22559			3	29		8	8	3551	C		3.361318e-17
ANK3	288	broad.mit.edu	37	chr10	61830234	61830234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggtcccacctttccctcctCctcgataacttcaagtttac	7	14	4	16	1	1	0	1	0	0	0	6	1	5	0	5	1	2	1	5	1	3	5			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61830234C>T	uc001jky.2	-	37	10597	c.10405G>A	c.(10405-10407)GAG>AAG	p.E3469K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3469					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTTCCCTCCTCCTCGATAACT	0.448													28	51					0	0	0	0	T	61830234	T	T	61830234	3	4	127	1	0	0	0	0	1	0	0	0	622	864	30	2	3069	2	ANK3	10	61830234	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	794	61830234	73704513	78	22560			3	29		8	8	3551	C		3.361318e-17
ANK3	288	broad.mit.edu	37	chr10	61831482	61831482	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcctttcctgggctaaactCtaaagaatcaggagatttgg	11	13	9	8	0	2	2	1	0	1	2	4	3	4	2	2	3	1	1	2	3	5	5			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61831482C>G	uc001jky.2	-	37	9349	c.9157G>C	c.(9157-9159)GAG>CAG	p.E3053Q	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3053					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGGCTAAACTCTAAAGAATCA	0.473													56	82					0	0	0	0	G	61831482	G	G	61831482	3	3	127	1	0	0	0	0	1	0	0	0	622	922	32	2	4317	2	ANK3	10	61831482	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	1248	61831482	73703265	79	22561			3	29		8	8	3551	C		3.361318e-17
ANK3	288	broad.mit.edu	37	chr10	61831782	61831782	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgtgacactgctgagctctCgctcctcctggaaggctgat	6	11	12	12	1	1	3	0	3	1	0	4	4	3	4	2	2	2	4	2	2	1	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61831782C>T	uc001jky.2	-	37	9049	c.8857G>A	c.(8857-8859)GAG>AAG	p.E2953K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2953					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GCTGAGCTCTCGCTCCTCCTG	0.468													24	54					0	0	0	0	T	61831782	T	T	61831782	3	4	127	1	0	0	0	0	1	0	0	0	622	893	31	1	4617	1	ANK3	10	61831782	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	300	61831782	73702965	80	22562			3	29		8	8	3551	C		3.361318e-17
ANK3	288	broad.mit.edu	37	chr10	61831830	61831830	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccgcctggatggtccccttCtttcacaacatattccctat	7	14	5	15	1	2	0	1	0	1	0	5	1	5	1	5	2	1	0	5	2	3	5			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61831830C>T	uc001jky.2	-	37	9001	c.8809G>A	c.(8809-8811)GAA>AAA	p.E2937K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2937					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TGGTCCCCTTCTTTCACAACA	0.443													14	38					0	0	0	0	T	61831830	T	T	61831830	3	4	127	1	0	0	0	0	1	0	0	0	622	922	32	2	4665	2	ANK3	10	61831830	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	48	61831830	73702917	81	22563			3	29		8	8	3551	C		3.361318e-17
ANK3	288	broad.mit.edu	37	chr10	61831953	61831953	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcagtcacagacataaattCattcttttgatcaacacttt	13	15	3	10	0	5	2	4	1	1	1	5	2	5	2	0	0	1	0	0	0	3	6			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:61831953C>T	uc001jky.2	-	37	8878	c.8686G>A	c.(8686-8688)GAA>AAA	p.E2896K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2896					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GACATAAATTCATTCTTTTGA	0.353													20	52					0	0	0	0	T	61831953	T	T	61831953	3	4	127	1	0	0	0	0	1	0	0	0	622	835	29	2	4788	2	ANK3	10	61831953	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	123	61831953	73702794	82	22564			3	29		8	8	3551	C		3.361318e-17
PAX2	5076	broad.mit.edu	37	chr10	102568873	102568873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctctcctcccaggggaacGagtactccctcccagccctg	6	8	8	19	1	1	0	0	0	1	0	6	2	5	1	5	2	3	1	5	2	2	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:102568873G>A	uc001krk.3	+	8	1418	c.868G>A	c.(868-870)GAG>AAG	p.E290K	PAX2_uc001krl.3_Missense_Mutation_p.E267K|PAX2_uc001krm.3_Missense_Mutation_p.E290K|PAX2_uc001kro.3_Missense_Mutation_p.E267K|PAX2_uc001krn.3_Missense_Mutation_p.E267K|PAX2_uc010qps.1_Missense_Mutation_p.E266K|PAX2_uc001krp.1_Missense_Mutation_p.E263K	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	290					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		CCAGGGGAACGAGTACTCCCT	0.587													40	111					0	0	0	0	A	102568873	A	A	102568873	3	1	127	1	0	0	0	0	1	0	0	0	11533	1059	37	1	898	1	PAX2	10	102568873	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	40736920	102568873	32965874	83	22565											
C10orf76	79591	broad.mit.edu	37	chr10	103799781	103799781	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggccttaccatgaagatctCatcatacatcagcaccactt	13	10	5	13	0	3	2	3	1	1	1	4	2	3	2	3	1	3	1	3	1	3	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:103799781C>G	uc009xwy.1	-	2	193	c.91G>C	c.(91-93)GAG>CAG	p.E31Q	C10orf76_uc001kui.2_Missense_Mutation_p.E31Q	NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	31						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		ATGAAGATCTCATCATACATC	0.458													67	129					0	0	0	0	G	103799781	G	G	103799781	3	3	127	1	0	0	0	0	1	0	0	0	1622	835	29	2	2078	2	C10orf76	10	103799781	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	1230908	103799781	31734966	84	22566											
KIAA1598	57698	broad.mit.edu	37	chr10	118646072	118646072	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcctgcatccaatgctactgGgaggcctatgagatgaagag	11	9	12	9	0	0	3	0	2	0	2	2	5	2	4	3	2	3	2	3	2	4	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr10:118646072G>T	uc009xyw.2	-	17	2177	c.1679C>A	c.(1678-1680)CCC>CAC	p.P560H	KIAA1598_uc001lcz.3_Silent_p.S455S|KIAA1598_uc010qso.1_Missense_Mutation_p.P500H|KIAA1598_uc001lcy.3_Missense_Mutation_p.P530H|KIAA1598_uc001lda.1_RNA	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	560					axon guidance	axon					0				all cancers(201;0.00494)		AATGCTACTGGGAGGCCTATG	0.373													26	48					4.7796e-09	5.08404e-09	1	0	T	118646072	T	T	118646072	3	4	127	1	0	0	0	0	1	0	0	0	8285	1232	43	4	220	4	KIAA1598	10	118646072	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	14846291	118646072	16888675	85	22567											
PLCB3	5331	broad.mit.edu	37	chr11	64022744	64022744	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcaagctggctatgaacatCctggctcagaacgcctcccg	9	9	9	14	2	2	2	2	1	0	1	4	2	4	2	3	2	3	3	3	2	4	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr11:64022744C>T	uc001nzb.2	+	5	426	c.426C>T	c.(424-426)ATC>ATT	p.I142I	PLCB3_uc009ypg.1_Silent_p.I142I|PLCB3_uc009yph.1_Silent_p.I75I|PLCB3_uc009ypi.2_Silent_p.I142I	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	142					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CTATGAACATCCTGGCTCAGA	0.647													11	22					0	0	0	0	T	64022744	T	T	64022744	2	4	127	1	0	0	0	0	0	0	0	1	12084	845	30	2		2	PLCB3	11	64022744	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08		64022744	70983772	86	22568											
FGF19	9965	broad.mit.edu	37	chr11	69514326	69514326	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcctcctcgaaagcacagtCttcctccgagtactgaagct	9	10	7	15	2	1	1	0	1	1	0	6	3	5	1	4	0	3	3	4	0	3	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr11:69514326C>T	uc001opf.2	-	3	818	c.355G>A	c.(355-357)GAC>AAC	p.D119N		NM_005117	NP_005108	O95750	FGF19_HUMAN	fibroblast growth factor 19 precursor	119					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of bile acid biosynthetic process|nervous system development|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import|positive regulation of JNK cascade	extracellular region	fibroblast growth factor receptor binding|growth factor activity			skin(1)	1	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;3.05e-56)|all cancers(3;2.69e-50)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			AAAGCACAGTCTTCCTCCGAG	0.567													10	17					0	0	0	0	T	69514326	T	T	69514326	3	4	127	1	0	0	0	0	1	0	0	0	5879	913	32	2	299	2	FGF19	11	69514326	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	5491582	69514326	65492190	87	22569											
POLD3	10714	broad.mit.edu	37	chr11	74340350	74340350	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatcaaacttcctgaatctGatagcagtgaagatgaaggt	15	10	10	6	0	2	5	1	4	1	1	3	6	3	5	1	1	2	1	1	1	6	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr11:74340350G>C	uc001ovf.1	+	9	1063	c.988G>C	c.(988-990)GAT>CAT	p.D330H	POLD3_uc009yua.1_Missense_Mutation_p.D224H	NM_006591	NP_006582	Q15054	DPOD3_HUMAN	DNA-directed DNA polymerase delta 3	330					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			kidney(2)|ovary(1)	3	Breast(11;3.21e-06)					TCCTGAATCTGATAGCAGTGA	0.398													40	41					0	0	0	0	C	74340350	C	C	74340350	3	2	127	1	0	0	0	0	1	0	0	0	12247	1290	45	2	1022	2	POLD3	11	74340350	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	4826024	74340350	60666166	88	22570											
APOA5	116519	broad.mit.edu	37	chr11	116661546	116661546	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctgctccatcagatccatCgtgtagggcttcagttgctg	7	12	10	12	1	2	1	2	0	0	1	5	1	4	1	3	1	2	5	3	1	1	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr11:116661546C>T	uc001ppr.2	-	3	407	c.399G>A	c.(397-399)ACG>ACA	p.T133T	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Silent_p.T133T|APOA5_uc009yzf.2_Silent_p.T133T|APOA5_uc009yzg.2_Silent_p.T159T	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	133	Potential.				acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		TCAGATCCATCGTGTAGGGCT	0.652													28	17					0	0	0	0	T	116661546	T	T	116661546	2	4	127	1	0	0	0	0	0	0	0	1	784	871	31	1		1	APOA5	11	116661546	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08	42321196	116661546	18344970	89	22571											
FOXM1	2305	broad.mit.edu	37	chr12	2968408	2968408	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaagtactgggcccctctGagaagagcagctccggctca	9	6	14	12	1	2	2	1	1	1	2	3	4	3	3	3	3	3	4	3	3	3	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:2968408G>A	uc001qlf.2	-	9	1953	c.1688C>T	c.(1687-1689)TCA>TTA	p.S563L	uc001qld.2_Intron|FOXM1_uc001qle.2_Missense_Mutation_p.S601L|FOXM1_uc001qlg.2_Missense_Mutation_p.S548L|FOXM1_uc009zea.2_Missense_Mutation_p.S548L|FOXM1_uc009zeb.2_Missense_Mutation_p.S547L	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	563					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GGGCCCCTCTGAGAAGAGCAG	0.612													20	30					0	0	0	0	A	2968408	A	A	2968408	3	1	127	1	0	0	0	0	1	0	0	0	6052	1294	45	2	607	2	FOXM1	12	2968408	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08		2968408	130883487	90	22572											
ANO2	57101	broad.mit.edu	37	chr12	6031929	6031929	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccccctctggaccctgcctGagggctcagccggcgtgggg	3	6	16	16	2	2	1	1	1	1	0	2	2	2	2	5	5	2	1	5	5	0	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:6031929G>A	uc001qnm.2	-	2	124	c.52C>T	c.(52-54)CAG>TAG	p.Q18*		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	22	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						GACCCTGCCTGAGGGCTCAGC	0.622													10	18					0	0	0	0	A	6031929	A	A	6031929	4	1	127	1	0	0	0	0	0	1	0	0	697	1299	45	2	3044	2	ANO2	12	6031929	Nonsense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	3063521	6031929	127819966	91	22573											
TAS2R31	259290	broad.mit.edu	37	chr12	11183373	11183373	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acatagcagggtcagagtgaAgggcactaagtttcctagcg	12	8	13	8	1	1	2	1	1	0	1	2	2	2	2	1	2	2	3	1	2	4	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:11183373A>T	uc001qzo.1	-	1	634	c.562T>A	c.(562-564)TTC>ATC	p.F188I	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	188	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						GTCAGAGTGAAGGGCACTAAG	0.428													41	92					0	0	0	0	T	11183373	T	T	11183373	3	4	127	1	0	0	0	0	1	0	0	0	15640	72	3	5	371	5	TAS2R31	12	11183373	Missense_Mutation	SNP	A	TCGA-CR-6480-01A-11D-1870-08	5151444	11183373	122668522	92	22574											
CDKN1B	1027	broad.mit.edu	37	chr12	12871106	12871106	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagagccaggatgtcagcggGagccgcccggcggcgccttt	6	5	17	13	5	1	1	1	0	0	1	1	4	1	3	4	4	3	0	4	4	0	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:12871106G>A	uc001rat.2	+	1	805	c.333G>A	c.(331-333)GGG>GGA	p.G111G		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	111					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		ATGTCAGCGGGAGCCGCCCGG	0.647									Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				32	42					0	0	0	0	A	12871106	A	A	12871106	2	1	127	1	0	0	0	0	0	0	0	1	3174	1161	41	2		2	CDKN1B	12	12871106	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	1687733	12871106	120980789	93	22575											
ANKRD13A	88455	broad.mit.edu	37	chr12	110463612	110463618	+	Frame_Shift_Del	DEL	AAAAAAG	-	-																															gaacatctgaccgaggaggaAaaaaagagatataaaggtaa																										TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:110463612_110463618delAAAAAAG	uc001tpx.2	+	8	1126_1132	c.867_873delAAAAAAG	c.(865-873)GAAAAAAAGfs	p.E289fs	ANKRD13A_uc009zvl.1_RNA|ANKRD13A_uc010sxw.1_Frame_Shift_Del_p.E289fs|ANKRD13A_uc001tpy.2_5'UTR|ANKRD13A_uc001tpz.2_5'Flank	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13	289_291											0						CCGAGGAGGAAAAAAAGAGATATAAAG	0.406													---	---	---								-	110463618	-	-	110463612	7	5	127	1	0	1	0	1	0	0	0	0	641	11	1	0	897	0	ANKRD13A	12	110463612	Frame_Shift_Del	DEL	AAAAAAG	TCGA-CR-6480-01A-11D-1870-08	97592506	110463612	23388283	94	22576											
VSIG10	54621	broad.mit.edu	37	chr12	118506244	118506244	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattcaccaaggcggtcactCtgtgaatgtggtcctgctta	8	12	10	11	1	3	1	2	1	1	0	4	1	4	1	2	3	1	1	2	3	3	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr12:118506244C>G	uc001tws.2	-	8	1839	c.1505G>C	c.(1504-1506)AGA>ACA	p.R502T		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	502	Cytoplasmic (Potential).					integral to membrane					0						GGCGGTCACTCTGTGAATGTG	0.408													37	77					0	0	0	0	G	118506244	G	G	118506244	3	3	127	1	0	0	0	0	1	0	0	0	17291	913	32	2	125	2	VSIG10	12	118506244	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	8042632	118506244	15345651	95	22577											
ATP5S	27109	broad.mit.edu	37	chr14	50789270	50789270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgttggccctgacagggCggcatccgagtggttgctgc	5	9	17	10	2	0	1	0	1	0	0	1	3	1	2	2	5	2	4	2	5	0	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr14:50789270C>T	uc001wxw.1	+	3	886	c.194C>T	c.(193-195)GCG>GTG	p.A65V	ATP5S_uc001wxv.2_Missense_Mutation_p.A65V|ATP5S_uc001wxx.1_Missense_Mutation_p.A65V|ATP5S_uc010ant.1_Missense_Mutation_p.A37V	NM_001003803	NP_001003803	Q99766	ATP5S_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	65					ATP biosynthetic process	mitochondrial inner membrane|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			ovary(1)|skin(1)	2	all_epithelial(31;0.000636)|Breast(41;0.0102)			OV - Ovarian serous cystadenocarcinoma(311;0.0685)		CCTGACAGGGCGGCATCCGAG	0.527													20	40					0	0	0	0	T	50789270	T	T	50789270	3	4	127	1	0	0	0	0	1	0	0	0	1165	768	27	1	204	1	ATP5S	14	50789270	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08		50789270	56560270	96	22578											
ACOT2	10965	broad.mit.edu	37	chr14	74040259	74040259	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgctccatctggagtactttGaagaagccatgaactacttg	11	11	9	10	1	1	3	0	2	1	1	2	4	2	4	2	1	4	2	2	1	5	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr14:74040259G>A	uc001xon.3	+	2	984	c.811G>A	c.(811-813)GAA>AAA	p.E271K	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_Missense_Mutation_p.E74K	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	271					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		GGAGTACTTTGAAGAAGCCAT	0.453													62	89					0	0	0	0	A	74040259	A	A	74040259	3	1	127	1	0	0	0	0	1	0	0	0	152	1291	45	2	817	2	ACOT2	14	74040259	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	23250989	74040259	33309281	97	22579											
C15orf52	388115	broad.mit.edu	37	chr15	40627456	40627456	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctcgtgggccggcttctcGgggccaggccctgctgggcc	1	8	16	16	3	2	0	0	0	2	0	4	0	2	0	4	6	1	2	4	6	0	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:40627456G>C	uc001zlh.3	-	11	1524	c.1508C>G	c.(1507-1509)CCG>CGG	p.P503R	C15orf52_uc010ucn.1_Missense_Mutation_p.P293R	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	503										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CCGGCTTCTCGGGGCCAGGCC	0.667													5	127					0	0	0	0	C	40627456	C	C	40627456	3	2	127	1	0	0	0	0	1	0	0	0	1806	1116	39	3	100	3	C15orf52	15	40627456	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08		40627456	61903936	98	22580											
B2M	567	broad.mit.edu	37	chr15	45003747	45003747	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagcattcgggccgagatGtctcgctccgtggccttagc	6	9	13	13	4	1	1	0	0	1	1	4	3	2	1	3	2	2	2	3	2	1	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:45003747G>T	uc001zuc.2	+	1	63	c.3G>T	c.(1-3)ATG>ATT	p.M1I	B2M_uc010uek.1_Missense_Mutation_p.M1I|B2M_uc010bdx.1_Missense_Mutation_p.M1I	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	1					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.M1V(2)		ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GGGCCGAGATGTCTCGCTCCG	0.612													20	17					1.96895e-08	2.0811e-08	1	0	T	45003747	T	T	45003747	3	4	127	1	0	0	0	0	1	0	0	0	1246	1377	48	4	5	4	B2M	15	45003747	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	4376291	45003747	57527645	99	22581											
FBN1	2200	broad.mit.edu	37	chr15	48737641	48737641	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcactggaaagaccccactGtattaatgcattggccattt	11	11	9	10	0	0	1	0	0	0	1	0	2	0	2	3	3	1	3	3	3	3	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:48737641G>C	uc001zwx.1	-	48	6177	c.5849C>G	c.(5848-5850)ACA>AGA	p.T1950R	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1950	EGF-like 33; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGACCCCACTGTATTAATGCA	0.438													41	59					0	0	0	0	C	48737641	C	C	48737641	3	2	127	1	0	0	0	0	1	0	0	0	5734	1377	48	4	2842	4	FBN1	15	48737641	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	3733894	48737641	53793751	100	22582											
SLTM	79811	broad.mit.edu	37	chr15	59172279	59172279	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atggaattgccactgatttgTacaattctattaattgggga	12	15	9	5	0	1	1	0	1	1	0	1	3	1	3	1	3	2	1	1	3	5	7			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:59172279T>C	uc002afp.2	-	21	3112	c.3024A>G	c.(3022-3024)GTA>GTG	p.V1008V	SLTM_uc002afn.2_Silent_p.V550V|SLTM_uc002afo.2_Silent_p.V990V|SLTM_uc002afq.2_Silent_p.V577V|SLTM_uc010bgd.2_Silent_p.V577V	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	1008					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						CACTGATTTGTACAATTCTAT	0.378													7	55					0	0	0	0	C	59172279	C	C	59172279	2	2	127	1	0	0	0	0	0	0	0	1	14818	1625	57	5		5	SLTM	15	59172279	Silent	SNP	T	TCGA-CR-6480-01A-11D-1870-08	10434638	59172279	43359113	101	22583											
HERC1	8925	broad.mit.edu	37	chr15	64026927	64026927	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaagcaaaggcctacctgtCctttagataagctttcccat	11	11	7	12	0	0	1	0	0	0	1	2	1	2	1	4	1	3	3	4	1	5	5			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:64026927C>A	uc002amp.2	-	13	2790	c.2642G>T	c.(2641-2643)GGA>GTA	p.G881V	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	881					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GCCTACCTGTCCTTTAGATAA	0.403													25	49					7.76418e-22	8.47463e-22	1	0	A	64026927	A	A	64026927	3	1	127	1	0	0	0	0	1	0	0	0	7096	855	30	2	12207	2	HERC1	15	64026927	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	4854648	64026927	38504465	102	22584											
LCTL	197021	broad.mit.edu	37	chr15	66855887	66855887	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtggtgcaaggtcacgatGggagtgatgttgctgctcag	8	10	16	7	1	2	1	2	1	0	0	2	3	2	2	0	3	3	4	0	3	1	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:66855887G>A	uc002aqc.2	-	4	579	c.447C>T	c.(445-447)CCC>CCT	p.P149P	LCTL_uc002aqd.3_5'UTR|LCTL_uc010bhw.2_5'UTR	NM_207338	NP_997221	Q6UWM7	LCTL_HUMAN	lactase-like precursor	149	Extracellular (Potential).				carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2						AGGTCACGATGGGAGTGATGT	0.527													20	34					0	0	0	0	A	66855887	A	A	66855887	2	1	127	1	0	0	0	0	0	0	0	1	8734	1335	47	4		4	LCTL	15	66855887	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	2828960	66855887	35675505	103	22585											
DNAJA4	55466	broad.mit.edu	37	chr15	78557113	78557113	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccgcagacacaagatggtgaAggagacccagtactatgaca	15	5	11	10	1	0	5	0	2	0	3	0	6	0	5	2	2	1	2	2	2	4	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr15:78557113A>G	uc002bdj.1	+	1	125	c.8A>G	c.(7-9)AAG>AGG	p.K3R	DNAJA4_uc002bdi.2_Missense_Mutation_p.K32R|DNAJA4_uc002bdk.2_5'Flank	NM_001130182	NP_001123654	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	3					protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			skin(1)	1						AAGATGGTGAAGGAGACCCAG	0.507													3	13					0	0	0	0	G	78557113	G	G	78557113	3	3	127	1	0	0	0	0	1	0	0	0	4636	72	3	5	101	5	DNAJA4	15	78557113	Missense_Mutation	SNP	A	TCGA-CR-6480-01A-11D-1870-08	11701226	78557113	23974279	104	22586											
BTBD12	84464	broad.mit.edu	37	chr16	3639417	3639417	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggggggcttctgttggcctGatgggaggccacctcctgct	3	11	16	11	0	1	1	0	1	1	0	2	2	2	2	4	6	1	3	4	6	0	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr16:3639417G>A	uc002cvp.2	-	12	4849	c.4222C>T	c.(4222-4224)CAG>TAG	p.Q1408*		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1408	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CTGTTGGCCTGATGGGAGGCC	0.607								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				49	62					0	0	0	0	A	3639417	A	A	3639417	4	1	127	1	0	0	0	0	0	1	0	0	1545	1299	45	2	1298	2	BTBD12	16	3639417	Nonsense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08		3639417	86715336	105	22587											
CIITA	4261	broad.mit.edu	37	chr16	10995908	10995908	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacagctgagccccccacTgtggtgactggcagtctcct	6	9	10	16	0	2	2	1	2	1	0	3	2	2	2	4	2	2	2	4	2	0	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr16:10995908T>A	uc002dai.3	+	7	628	c.495T>A	c.(493-495)ACT>ACA	p.T165T	CIITA_uc002daj.3_Silent_p.T166T|CIITA_uc002dak.3_Intron|CIITA_uc002dag.2_Silent_p.T165T|CIITA_uc002dah.2_Intron|CIITA_uc010bup.1_Silent_p.T165T	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	165					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						AGCCCCCCACTGTGGTGACTG	0.647			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								4	127					0	0	0	0	A	10995908	A	A	10995908	2	1	127	1	0	0	0	0	0	0	0	1	3443	1567	55	5		5	CIITA	16	10995908	Silent	SNP	T	TCGA-CR-6480-01A-11D-1870-08	7356491	10995908	79358845	106	22588											
PRPF8	10594	broad.mit.edu	37	chr17	1582626	1582626	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccgatgcttcagggcattCagcacatagtacttaagcag	11	9	11	10	1	2	0	2	0	0	0	2	1	2	0	1	2	4	5	1	2	3	5			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:1582626C>T	uc002fte.2	-	10	1482	c.1368G>A	c.(1366-1368)CTG>CTA	p.L456L		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	456						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCAGGGCATTCAGCACATAGT	0.542													38	66					0	0	0	0	T	1582626	T	T	1582626	2	4	127	1	0	0	0	0	0	0	0	1	12637	813	29	2		2	PRPF8	17	1582626	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08		1582626	79612584	107	22589											
CORO6	84940	broad.mit.edu	37	chr17	27943185	27943185	+	Silent	SNP	G	A	A																															gggtacagatcgtcctggaaGaggtctgactgcgggggtgg																										TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:27943185G>A	uc002hel.2	-	9	1073	c.1071C>T	c.(1069-1071)CTC>CTT	p.L357L	CORO6_uc002hem.2_Silent_p.L123L|CORO6_uc002hen.2_Silent_p.L123L	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	357					actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						CGTCCTGGAAGAGGTCTGACT	0.667													8	13					0	0	0	0	A	27943185	A	A	27943185	2	1	127	1	0	0	0	0	0	0	0	1	3773	929	33	2		2	CORO6	17	27943185	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	26360559	27943185	53252025	108	22590	45	2									
CORO6	84940	broad.mit.edu	37	chr17	27943190	27943190	+	Missense_Mutation	SNP	C	G	G																															cagatcgtcctggaagaggtCtgactgcgggggtgggtgga																										TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:27943190C>G	uc002hel.2	-	9	1068	c.1066G>C	c.(1066-1068)GAC>CAC	p.D356H	CORO6_uc002hem.2_Missense_Mutation_p.D122H|CORO6_uc002hen.2_Missense_Mutation_p.D122H	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	356					actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						TGGAAGAGGTCTGACTGCGGG	0.677													7	14					0	0	0	0	G	27943190	G	G	27943190	3	3	127	1	0	0	0	0	1	0	0	0	3773	913	32	2	360	2	CORO6	17	27943190	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	5	27943190	53252020	109	22591	45	2									
AMAC1	146861	broad.mit.edu	37	chr17	33520392	33520392	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccagcacaacccctgccGccacgatgtcagaaggtgcc	9	5	10	17	2	1	1	1	0	0	1	1	2	1	1	6	1	5	1	6	1	2	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:33520392G>C	uc002hjd.2	-	1	1021	c.935C>G	c.(934-936)GCG>GGG	p.A312G		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	312	DUF6 2.|Helical; (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		AACCCCTGCCGCCACGATGTC	0.567													6	140					0	0	0	0	C	33520392	C	C	33520392	3	2	127	1	0	0	0	0	1	0	0	0	559	1087	38	3	85	3	AMAC1	17	33520392	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	5577202	33520392	47674818	110	22592											
EZH1	2145	broad.mit.edu	37	chr17	40870631	40870631	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgacatctctgttagttctcGatacctatttaagaaaagag	13	14	7	7	1	2	3	0	1	2	2	4	4	2	3	1	0	1	2	1	0	6	6			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:40870631G>A	uc002iaz.2	-	9	917	c.772C>T	c.(772-774)CGA>TGA	p.R258*	EZH1_uc002iba.2_Nonsense_Mutation_p.R249*|EZH1_uc010wgt.1_Nonsense_Mutation_p.R188*|EZH1_uc010wgu.1_Nonsense_Mutation_p.R264*|EZH1_uc010wgv.1_Nonsense_Mutation_p.R218*|EZH1_uc010wgw.1_Nonsense_Mutation_p.R119*|EZH1_uc010cyp.2_Nonsense_Mutation_p.R159*|EZH1_uc010cyq.2_Nonsense_Mutation_p.R175*|EZH1_uc010cys.2_Nonsense_Mutation_p.R209*|EZH1_uc010cyo.1_Intron|EZH1_uc010cyr.1_Intron	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	258					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		GTTAGTTCTCGATACCTATTT	0.507													16	36					0	0	0	0	A	40870631	A	A	40870631	4	1	127	1	0	0	0	0	0	1	0	0	5358	1066	37	1	1523	1	EZH1	17	40870631	Nonsense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	7350239	40870631	40324579	111	22593											
GPRC5C	55890	broad.mit.edu	37	chr17	72436363	72436363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctggcccggaagaaccacGggccccggggctgggtgatc	6	5	16	14	3	0	2	0	1	0	1	2	3	1	3	5	6	1	1	5	6	2	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:72436363G>A	uc002jks.2	+	1	487	c.448G>A	c.(448-450)GGG>AGG	p.G150R	GPRC5C_uc002jkp.2_Missense_Mutation_p.G195R|GPRC5C_uc002jkq.2_Intron|GPRC5C_uc002jkr.2_Missense_Mutation_p.G162R|GPRC5C_uc002jkt.2_Missense_Mutation_p.G150R|GPRC5C_uc002jku.2_5'Flank	NM_018653	NP_061123	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	150	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5						GAAGAACCACGGGCCCCGGGG	0.597													4	101					0	0	0	0	A	72436363	A	A	72436363	3	1	127	1	0	0	0	0	1	0	0	0	6765	1116	39	1	597	1	GPRC5C	17	72436363	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	31565732	72436363	8758847	112	22594											
GALR2	8811	broad.mit.edu	37	chr17	74072818	74072818	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggggctgtcgctgctcttctCcgggccctacctgagctact	3	11	12	15	2	2	1	0	1	2	0	4	1	2	1	3	3	4	4	3	3	2	3			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:74072818C>G	uc002jqm.1	+	2	551	c.470C>G	c.(469-471)TCC>TGC	p.S157C	ZACN_uc002jqn.2_5'Flank|ZACN_uc002jqo.2_5'Flank|ZACN_uc010dgu.2_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	157	Helical; Name=4; (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						CTGCTCTTCTCCGGGCCCTAC	0.692													14	35					0	0	0	0	G	74072818	G	G	74072818	3	3	127	1	0	0	0	0	1	0	0	0	6263	855	30	2	476	2	GALR2	17	74072818	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	1636455	74072818	7122392	113	22595											
ST6GALNAC1	55808	broad.mit.edu	37	chr17	74625693	74625693	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgttctctggcactggctCtgcatagatggttgtcctcc	5	15	10	11	0	2	1	0	0	2	1	5	1	4	1	2	3	1	5	2	3	1	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr17:74625693C>T	uc002jsh.2	-	2	406	c.232G>A	c.(232-234)GAG>AAG	p.E78K	ST6GALNAC1_uc002jsi.2_5'UTR|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	78	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						GGCACTGGCTCTGCATAGATG	0.567													53	88					0	0	0	0	T	74625693	T	T	74625693	3	4	127	1	0	0	0	0	1	0	0	0	15289	922	32	2	1602	2	ST6GALNAC1	17	74625693	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	552875	74625693	6569517	114	22596											
NFATC1	4772	broad.mit.edu	37	chr18	77208872	77208872	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgcccgcacgccttctacCaggtgcaccgcatcacaggg	7	6	11	17	4	2	0	1	0	1	0	2	0	2	0	4	2	3	3	4	2	1	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr18:77208872C>T	uc010xfg.1	+	4	1930	c.1477C>T	c.(1477-1479)CAG>TAG	p.Q493*	NFATC1_uc002lnc.1_Nonsense_Mutation_p.Q493*|NFATC1_uc010xff.1_Nonsense_Mutation_p.Q493*|NFATC1_uc002lnd.2_Nonsense_Mutation_p.Q493*|NFATC1_uc002lne.2_Nonsense_Mutation_p.Q21*|NFATC1_uc010xfh.1_Nonsense_Mutation_p.Q493*|NFATC1_uc010xfi.1_Nonsense_Mutation_p.Q480*|NFATC1_uc010xfj.1_Nonsense_Mutation_p.Q21*|NFATC1_uc002lnf.2_Nonsense_Mutation_p.Q480*|NFATC1_uc002lng.2_Nonsense_Mutation_p.Q480*|NFATC1_uc010xfk.1_Nonsense_Mutation_p.Q480*	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	493	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CGCCTTCTACCAGGTGCACCG	0.622													18	13					0	0	0	0	T	77208872	T	T	77208872	4	4	127	1	0	0	0	0	0	1	0	0	10415	595	21	4	1583	4	NFATC1	18	77208872	Nonsense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08		77208872	868376	115	22597											
KIAA1543	57662	broad.mit.edu	37	chr19	7677766	7677766	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcggctggcacccttgaccaGggtgcttacgccaccccacg	6	6	12	17	3	0	1	0	1	0	0	0	1	0	1	5	3	2	3	5	3	1	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr19:7677766G>A	uc002mgv.3	+	11	2488	c.2387G>A	c.(2386-2388)AGG>AAG	p.R796K	KIAA1543_uc002mgu.3_Missense_Mutation_p.R823K|KIAA1543_uc002mgw.2_5'Flank	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	796	Pro-rich.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						CCCTTGACCAGGGTGCTTACG	0.726													3	8					0	0	0	0	A	7677766	A	A	7677766	3	1	127	1	0	0	0	0	1	0	0	0	8282	1000	35	4	2518	4	KIAA1543	19	7677766	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08		7677766	51451217	116	22598											
FBXW9	84261	broad.mit.edu	37	chr19	12807411	12807411	+	5'Flank	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccattgcgaccgggtgggcGctgccggcctcgcgtcttgt	2	10	15	14	6	1	0	0	0	1	0	3	1	2	0	4	3	2	1	4	3	0	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr19:12807411G>A	uc010dyx.2	-						FBXW9_uc010xmp.1_RNA|FBXW9_uc002mum.1_5'UTR|FBXW9_uc002mun.1_5'UTR	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9								protein binding			ovary(1)	1						CCGGGTGGGCGCTGCCGGCCT	0.647													19	34					0	0	0	0	A	12807411	A	A	12807411	1	1	127	0	1	0	0	0	0	0	0	0	5803	1102	38	1		1	FBXW9	19	12807411	5'Flank	SNP	G	TCGA-CR-6480-01A-11D-1870-08	5129645	12807411	46321572	117	22599											
SLC1A5	6510	broad.mit.edu	37	chr19	47282157	47282157	+	Frame_Shift_Del	DEL	G	-	-																															ccaggaacatgatgcccacaGgggcgtacctgatcagtaac																										TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr19:47282157delG	uc002pfs.2	-	5	1453	c.833delC	c.(832-834)CCTfs	p.P278fs	SLC1A5_uc010xyh.1_Frame_Shift_Del_p.P76fs|SLC1A5_uc002pfq.2_Frame_Shift_Del_p.P102fs|SLC1A5_uc002pfr.2_Frame_Shift_Del_p.P50fs	NM_005628	NP_005619	Q15758	AAAT_HUMAN	solute carrier family 1 member 5 isoform 1	278	Helical; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity				0		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	GATGCCCACAGGGGCGTACCT	0.582													---	---	---								-	47282157	-	-	47282157	7	5	127	1	0	1	0	1	0	0	0	0	14500	1000	35	0	808	0	SLC1A5	19	47282157	Frame_Shift_Del	DEL	G	TCGA-CR-6480-01A-11D-1870-08	34474746	47282157	11846826	118	22600											
ZNF331	55422	broad.mit.edu	37	chr19	54080933	54080933	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctatcacctcactcagcaCgagagaatccacacaggcga	13	5	9	14	2	3	1	3	0	0	1	4	4	4	1	2	2	1	2	2	2	2	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr19:54080933C>T	uc002qbx.1	+	7	2553	c.1119C>T	c.(1117-1119)CAC>CAT	p.H373H	ZNF331_uc002qby.1_Silent_p.H373H|ZNF331_uc002qbz.1_Silent_p.H373H|ZNF331_uc002qca.1_Silent_p.H373H|ZNF331_uc010eqr.1_Silent_p.H373H|ZNF331_uc002qcb.1_Silent_p.H373H|ZNF331_uc002qcc.1_Silent_p.H373H|ZNF331_uc002qcd.1_Silent_p.H373H	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	373	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		TCACTCAGCACGAGAGAATCC	0.498			T	?	follicular thyroid adenoma								7	39					0	0	0	0	T	54080933	T	T	54080933	2	4	127	1	0	0	0	0	0	0	0	1	17916	535	19	1		1	ZNF331	19	54080933	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08	6798776	54080933	5048050	119	22601											
ZNF337	26152	broad.mit.edu	37	chr20	25657009	25657009	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcaagtgcttgttgtatgaGgacttatcgttaaaccttcg	9	16	9	7	2	1	1	1	1	0	0	3	2	1	2	1	1	2	4	1	1	5	7			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr20:25657009G>C	uc002wva.2	-	4	1437	c.915C>G	c.(913-915)TCC>TCG	p.S305S	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Silent_p.S273S|ZNF337_uc002wvb.2_Silent_p.S305S|ZNF337_uc002wvc.2_Silent_p.S305S	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	305	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTTGTATGAGGACTTATCGT	0.473													79	127					0	0	0	0	C	25657009	C	C	25657009	2	2	127	1	0	0	0	0	0	0	0	1	17920	987	35	4		4	ZNF337	20	25657009	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08		25657009	37368511	120	22602											
C20orf112	140688	broad.mit.edu	37	chr20	31062481	31062481	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaggctggaggccaggtgcGggtcagctgacatccatgtg	7	8	16	10	1	2	1	2	1	0	0	3	2	3	2	2	5	2	2	2	5	0	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr20:31062481G>A	uc002wxu.3	-	2	189	c.32C>T	c.(31-33)CCG>CTG	p.P11L	C20orf112_uc010gec.2_5'UTR|C20orf112_uc002wxv.3_Missense_Mutation_p.P11L|C20orf112_uc002wxw.1_RNA	NM_080616	NP_542183	Q96MY1	CT112_HUMAN	hypothetical protein LOC140688	11											0						GGCCAGGTGCGGGTCAGCTGA	0.597													12	23					0	0	0	0	A	31062481	A	A	31062481	3	1	127	1	0	0	0	0	1	0	0	0	2091	1116	39	1	1306	1	C20orf112	20	31062481	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	5405472	31062481	31963039	121	22603											
ZNF512B	57473	broad.mit.edu	37	chr20	62598782	62598782	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttttggccgcccctttttCttcccttctgtcttgtcact	1	19	6	15	1	4	0	1	0	3	0	5	0	5	0	4	1	0	1	4	1	0	7			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr20:62598782C>T	uc002yhl.1	-	3	270	c.216G>A	c.(214-216)AAG>AAA	p.K72K		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	72					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GCCCCTTTTTCTTCCCTTCTG	0.632													58	85					0	0	0	0	T	62598782	T	T	62598782	2	4	127	1	0	0	0	0	0	0	0	1	18024	912	32	2		2	ZNF512B	20	62598782	Silent	SNP	C	TCGA-CR-6480-01A-11D-1870-08	31536301	62598782	426738	122	22604											
KRTAP27-1	643812	broad.mit.edu	37	chr21	31709410	31709410	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtaacacagcaagttggttCaactcctggagaagattcca	14	9	9	9	0	1	2	1	0	0	2	3	3	3	2	2	2	3	4	2	2	4	4			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr21:31709410C>G	uc002ynx.1	-	1	603	c.577G>C	c.(577-579)GAA>CAA	p.E193Q		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	193						intermediate filament				ovary(2)	2						CAAGTTGGTTCAACTCCTGGA	0.443													23	24					0	0	0	0	G	31709410	G	G	31709410	3	3	127	1	0	0	0	0	1	0	0	0	8584	835	29	2	50	2	KRTAP27-1	21	31709410	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08		31709410	16420485	123	22605											
LRRC3	81543	broad.mit.edu	37	chr21	45876816	45876816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagggagctggatctgtctCacaacgccatcgaggccatc	9	8	11	13	2	3	0	2	0	2	0	6	3	3	2	2	3	2	1	2	3	1	0			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr21:45876816C>T	uc002zfa.2	+	2	582	c.289C>T	c.(289-291)CAC>TAC	p.H97Y		NM_030891	NP_112153	Q9BY71	LRRC3_HUMAN	leucine-rich repeat-containing 3 precursor	97	LRR 2.					integral to membrane	protein binding				0		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		GGATCTGTCTCACAACGCCAT	0.662													23	46					0	0	0	0	T	45876816	T	T	45876816	3	4	127	1	0	0	0	0	1	0	0	0	9034	826	29	2	291	2	LRRC3	21	45876816	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	14167406	45876816	2253079	124	22606											
PPIL2	23759	broad.mit.edu	37	chr22	22049338	22049338	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttccgccagggcgtgggcaAgtacatcaacccagcagcca	10	5	11	15	2	1	0	1	0	0	0	2	0	2	0	4	2	4	3	4	2	3	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:22049338A>T	uc010gtj.1	+	19	1561	c.1445A>T	c.(1444-1446)AAG>ATG	p.K482M	PPIL2_uc002zvh.3_Missense_Mutation_p.K482M|PPIL2_uc002zvi.3_Missense_Mutation_p.K482M|PPIL2_uc002zvg.3_Missense_Mutation_p.K482M|PPIL2_uc011aij.1_Intron|PPIL2_uc002zvk.3_Missense_Mutation_p.K228M	NM_148175	NP_680480	Q13356	PPIL2_HUMAN	peptidylprolyl isomerase-like 2 isoform a	482					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			ovary(2)	2	Colorectal(54;0.105)					GGCGTGGGCAAGTACATCAAC	0.647													5	25					0	0	0	0	T	22049338	T	T	22049338	3	4	127	1	0	0	0	0	1	0	0	0	12387	72	3	5	1519	5	PPIL2	22	22049338	Missense_Mutation	SNP	A	TCGA-CR-6480-01A-11D-1870-08		22049338	29255228	125	22607											
YPEL1	29799	broad.mit.edu	37	chr22	22057704	22057704	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagttctcgcagtagatgtcGgcaaccgcatgcagcccggt	8	8	12	13	4	1	1	0	0	1	1	3	1	1	1	2	2	3	6	2	2	2	2			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:22057704G>A	uc002zvl.2	-	4	557	c.225C>T	c.(223-225)GCC>GCT	p.A75A	YPEL1_uc002zvm.2_RNA	NM_013313	NP_037445	O60688	YPEL1_HUMAN	yippee-like 1	75						nucleus					0	Colorectal(54;0.105)					AGTAGATGTCGGCAACCGCAT	0.642													32	70					0	0	0	0	A	22057704	A	A	22057704	2	1	127	1	0	0	0	0	0	0	0	1	17557	1103	39	1		1	YPEL1	22	22057704	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	8366	22057704	29246862	126	22608											
CELSR1	9620	broad.mit.edu	37	chr22	46776788	46776788	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctccaggggtctcgggagcgGagccccctcgctgtacacca	6	6	13	16	3	1	0	0	0	1	0	4	2	2	2	4	4	3	2	4	4	1	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:46776788G>C	uc003bhw.1	-	22	7153	c.7153C>G	c.(7153-7155)CCG>GCG	p.P2385A	CELSR1_uc011arc.1_Missense_Mutation_p.P706A	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2385	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CTCGGGAGCGGAGCCCCCTCG	0.627													13	27					0	0	0	0	C	46776788	C	C	46776788	3	2	127	1	0	0	0	0	1	0	0	0	3236	1174	41	2	1947	2	CELSR1	22	46776788	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	24719084	46776788	4527778	127	22609											
CRELD2	79174	broad.mit.edu	37	chr22	50319135	50319135	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aactgctacaatactccaggGagctacgtctgtgtgtgtcc	9	11	10	11	1	1	0	0	0	1	0	3	1	3	1	2	1	6	2	2	1	5	3	rs151259822		TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:50319135G>A	uc003bja.2	+	9	1074	c.939G>A	c.(937-939)GGG>GGA	p.G313G	CRELD2_uc010haj.2_Silent_p.G313G|CRELD2_uc010hal.2_Silent_p.G362G|CRELD2_uc010hak.2_Silent_p.G285G|CRELD2_uc010ham.2_Silent_p.G281G	NM_024324	NP_077300	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2 isoform b	313	EGF-like 2; calcium-binding (Potential).					endoplasmic reticulum|extracellular region	calcium ion binding				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		ATACTCCAGGGAGCTACGTCT	0.507													18	52					0	0	0	0	A	50319135	A	A	50319135	2	1	127	1	0	0	0	0	0	0	0	1	3882	1161	41	2		2	CRELD2	22	50319135	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08	3542347	50319135	985431	128	22610											
CRELD2	79174	broad.mit.edu	37	chr22	50319169	50319169	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgtcctgacggcttcgaaGaaacggaagatgcctgtgtg	9	10	14	8	3	0	3	0	1	0	2	2	5	1	4	2	2	2	1	2	2	3	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chr22:50319169G>A	uc003bja.2	+	9	1108	c.973G>A	c.(973-975)GAA>AAA	p.E325K	CRELD2_uc010haj.2_Missense_Mutation_p.E325K|CRELD2_uc010hal.2_Missense_Mutation_p.E374K|CRELD2_uc010hak.2_Missense_Mutation_p.E297K|CRELD2_uc010ham.2_Missense_Mutation_p.E293K	NM_024324	NP_077300	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2 isoform b	325	EGF-like 2; calcium-binding (Potential).					endoplasmic reticulum|extracellular region	calcium ion binding				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		CGGCTTCGAAGAAACGGAAGA	0.587													19	43					0	0	0	0	A	50319169	A	A	50319169	3	1	127	1	0	0	0	0	1	0	0	0	3882	943	33	2	1158	2	CRELD2	22	50319169	Missense_Mutation	SNP	G	TCGA-CR-6480-01A-11D-1870-08	34	50319169	985397	129	22611											
PGK1	5230	broad.mit.edu	37	chrX	77380864	77380864	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtgccaaatggaacacGgaggataaagtcagccatgt	13	8	12	8	1	1	0	1	0	0	0	1	3	1	3	2	3	4	1	2	3	4	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chrX:77380864G>T	uc004ecz.3	+	10	1327	c.1155G>T	c.(1153-1155)ACG>ACT	p.T385T	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_Silent_p.T357T	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	385					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						AATGGAACACGGAGGATAAAG	0.488													44	20					4.44712e-29	4.88598e-29	1	0	T	77380864	T	T	77380864	2	4	127	1	0	0	0	0	0	0	0	1	11845	1103	39	3		3	PGK1	23	77380864	Silent	SNP	G	TCGA-CR-6480-01A-11D-1870-08		77380864	77889696	130	22612											
CHM	1121	broad.mit.edu	37	chrX	85211360	85211360	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttgagtctttaaatattCataaaatgtgatctcttcat	12	20	4	5	0	4	2	2	2	2	0	5	2	4	2	0	0	0	0	0	0	5	8			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chrX:85211360C>T	uc004eet.2	-	8	994	c.964G>A	c.(964-966)GAA>AAA	p.E322K	CHM_uc011mqz.1_Missense_Mutation_p.E174K	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	322					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				TTTAAATATTCATAAAATGTG	0.333													11	3					0	0	0	0	T	85211360	T	T	85211360	3	4	127	1	0	0	0	0	1	0	0	0	3365	835	29	2	1029	2	CHM	23	85211360	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	7830496	85211360	70059200	131	22613											
MPP1	4354	broad.mit.edu	37	chrX	154033630	154033630	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgcccccactctcgccctCgctcgccttgagggtcatct	3	10	9	19	3	3	1	1	1	2	0	6	1	3	1	4	1	1	2	4	1	0	1			TCGA-CR-6480-01A-11D-1870-08	TCGA-CR-6480-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ee5501e-5463-4481-b798-3d23bfb4f113	9c2c99b3-9669-4bf2-81cc-d82c9611ea2f	g.chrX:154033630C>T	uc004fmp.1	-	1	134	c.19G>A	c.(19-21)GAG>AAG	p.E7K	MPP1_uc010nvg.1_Missense_Mutation_p.E7K|MPP1_uc011mzv.1_5'UTR|MPP1_uc004fmq.1_5'UTR|MPP1_uc011mzw.1_Missense_Mutation_p.E7K|MPP1_uc010nvh.1_Missense_Mutation_p.E7K	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	7					regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTCTCGCCCTCGCTCGCCTTG	0.662													5	2					0	0	0	0	T	154033630	T	T	154033630	3	4	127	1	0	0	0	0	1	0	0	0	9786	893	31	1	1445	1	MPP1	23	154033630	Missense_Mutation	SNP	C	TCGA-CR-6480-01A-11D-1870-08	68822270	154033630	1236930	132	22614											
ATAD3C	219293	broad.mit.edu	37	chr1	1390860	1390860	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtcagccggcggctcctCagtcgaccccaggacgtgct	6	6	13	16	4	2	0	2	0	0	0	4	2	3	1	4	4	2	2	4	4	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:1390860C>T	uc001aft.2	+	5	1394	c.399C>T	c.(397-399)CTC>CTT	p.L133L		NM_001039211	NP_001034300	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	133							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGCGGCTCCTCAGTCGACCCC	0.667													8	21					0	0	0	0	T	1390860	T	T	1390860	2	4	128	1	0	0	0	0	0	0	0	1	1077	813	29	2		2	ATAD3C	1	1390860	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08		1390860	247859761	1	22615											
SPSB1	80176	broad.mit.edu	37	chr1	9427562	9427562	+	Silent	SNP	G	C	C																															tcggtgcgcctggccctgggGagggagcgcctgggggagat																										TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:9427562G>C	uc010oae.1	+	3	1089	c.750G>C	c.(748-750)GGG>GGC	p.G250G	SPSB1_uc001apv.2_Silent_p.G250G	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	250	SOCS box.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		TGGCCCTGGGGAGGGAGCGCC	0.672													13	46					0	0	0	0	C	9427562	C	C	9427562	2	2	128	1	0	0	0	0	0	0	0	1	15178	1161	41	2		2	SPSB1	1	9427562	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	8036702	9427562	239823059	2	22616	46	2									
SPSB1	80176	broad.mit.edu	37	chr1	9427566	9427566	+	Missense_Mutation	SNP	G	A	A																															tgcgcctggccctggggaggGagcgcctgggggagatccac																										TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:9427566G>A	uc010oae.1	+	3	1093	c.754G>A	c.(754-756)GAG>AAG	p.E252K	SPSB1_uc001apv.2_Missense_Mutation_p.E252K	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	252	SOCS box.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		CCTGGGGAGGGAGCGCCTGGG	0.672													13	43					0	0	0	0	A	9427566	A	A	9427566	3	1	128	1	0	0	0	0	1	0	0	0	15178	1175	41	2	760	2	SPSB1	1	9427566	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4	9427566	239823055	3	22617	46	2									
CASZ1	54897	broad.mit.edu	37	chr1	10702951	10702951	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgttacccacgggggtgctgGagcagctccggtccatggtg	5	8	16	12	3	0	0	0	0	0	0	2	1	2	1	3	5	4	4	3	5	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:10702951G>A	uc001aro.2	-	20	4447	c.4127C>T	c.(4126-4128)TCC>TTC	p.S1376F		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1376					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GGGGGTGCTGGAGCAGCTCCG	0.667													3	22					0	0	0	0	A	10702951	A	A	10702951	3	1	128	1	0	0	0	0	1	0	0	0	2697	1174	41	2	1160	2	CASZ1	1	10702951	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1275385	10702951	238547670	4	22618											
CASZ1	54897	broad.mit.edu	37	chr1	10703259	10703259	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagttcttccccagcatcctCcgcatgtgcttccgcgcgtg	5	11	9	16	4	1	0	0	0	1	0	5	0	5	0	5	0	2	4	5	0	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:10703259C>T	uc001aro.2	-	19	4298	c.3978G>A	c.(3976-3978)CGG>CGA	p.R1326R		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CCAGCATCCTCCGCATGTGCT	0.652													7	49					0	0	0	0	T	10703259	T	T	10703259	2	4	128	1	0	0	0	0	0	0	0	1	2697	842	30	2		2	CASZ1	1	10703259	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	308	10703259	238547362	5	22619											
LOC649330	649330	broad.mit.edu	37	chr1	12907868	12907868	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtttcacacctgcgtttcctCggttcacttttggctctgca	4	16	8	13	2	3	0	2	0	1	0	5	0	4	0	2	2	2	5	2	2	0	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:12907868C>T	uc009vno.2	-	1	370	c.275G>A	c.(274-276)CGA>CAA	p.R92Q	HNRNPCL1_uc010obf.1_Missense_Mutation_p.R92Q	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	92							nucleic acid binding|nucleotide binding				0						TGCGTTTCCTCGGTTCACTTT	0.483													9	150					0	0	0	0	T	12907868	T	T	12907868	3	4	128	1	0	0	0	0	1	0	0	0	8935	884	31	1	610	1	LOC649330	1	12907868	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2204609	12907868	236342753	6	22620											
KAZ	23254	broad.mit.edu	37	chr1	15392164	15392164	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccaaaaacggaaaaagaaGaaagagaagatgggattcgg	21	3	13	4	2	0	4	0	0	0	4	1	8	0	6	1	3	1	0	1	3	7	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:15392164G>A	uc001avm.3	+	8	1418	c.1137G>A	c.(1135-1137)AAG>AAA	p.K379K	KAZ_uc009vog.1_Silent_p.K379K|KAZ_uc010obj.1_Silent_p.K379K|KAZ_uc001avo.2_Silent_p.K373K|KAZ_uc001avp.2_Silent_p.K285K|KAZ_uc001avq.2_Silent_p.K285K|KAZ_uc001avr.2_3'UTR	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	379	Poly-Lys.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						GGAAAAAGAAGAAAGAGAAGA	0.552													7	76					0	0	0	0	A	15392164	A	A	15392164	2	1	128	1	0	0	0	0	0	0	0	1	8027	933	33	2		2	KAZ	1	15392164	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2484296	15392164	233858457	7	22621											
CROCC	9696	broad.mit.edu	37	chr1	17292539	17292539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctgaatcgccagctggccGagatggaggctgagagggac	9	5	16	11	2	0	3	0	2	0	2	1	7	0	5	3	4	1	2	3	4	1	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:17292539G>A	uc001azt.2	+	29	4690	c.4621G>A	c.(4621-4623)GAG>AAG	p.E1541K	CROCC_uc001azu.2_Missense_Mutation_p.E844K|CROCC_uc001azv.2_5'Flank	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	1541	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CCAGCTGGCCGAGATGGAGGC	0.632													6	34					0	0	0	0	A	17292539	A	A	17292539	3	1	128	1	0	0	0	0	1	0	0	0	3908	1059	37	1	4735	1	CROCC	1	17292539	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1900375	17292539	231958082	8	22622											
RUNX3	864	broad.mit.edu	37	chr1	25254140	25254140	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgacggccgaggcattgcGcagctcagcggagtagttct	8	8	14	11	4	2	1	1	1	1	0	2	3	2	2	1	3	3	5	1	3	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:25254140G>A	uc001bjq.2	-	2	775	c.364C>T	c.(364-366)CGC>TGC	p.R122C	RUNX3_uc010oen.1_Missense_Mutation_p.R122C|RUNX3_uc009vrj.2_Missense_Mutation_p.R136C|RUNX3_uc001bjr.2_Missense_Mutation_p.R136C	NM_004350	NP_004341	Q13761	RUNX3_HUMAN	runt-related transcription factor 3 isoform 2	122	Runt.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		GAGGCATTGCGCAGCTCAGCG	0.632													14	104					0	0	0	0	A	25254140	A	A	25254140	3	1	128	1	0	0	0	0	1	0	0	0	13814	1087	38	1	899	1	RUNX3	1	25254140	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7961601	25254140	223996481	9	22623											
BAI2	576	broad.mit.edu	37	chr1	32210323	32210323	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcactttcggttcctcttccGgctcctcacctggaacacgg	5	12	8	16	3	3	0	2	0	1	0	7	1	6	1	4	4	1	2	4	4	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:32210323G>A	uc001btn.2	-	5	1202	c.848C>T	c.(847-849)CCG>CTG	p.P283L	BAI2_uc010ogo.1_5'UTR|BAI2_uc010ogp.1_Missense_Mutation_p.P271L|BAI2_uc010ogq.1_Missense_Mutation_p.P283L|BAI2_uc001bto.2_Missense_Mutation_p.P283L|BAI2_uc001btq.1_Missense_Mutation_p.P271L|BAI2_uc010ogr.1_Missense_Mutation_p.P271L	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	283	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TTCCTCTTCCGGCTCCTCACC	0.612													6	39					0	0	0	0	A	32210323	A	A	32210323	3	1	128	1	0	0	0	0	1	0	0	0	1301	1116	39	1	4025	1	BAI2	1	32210323	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	6956183	32210323	217040298	10	22624											
ZMYM1	79830	broad.mit.edu	37	chr1	35578687	35578687	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagtcagcatgcaattggttCcagtacagaagtacaaaaag	16	8	9	8	0	1	1	1	0	0	1	2	1	2	1	1	1	4	5	1	1	6	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:35578687C>T	uc001bym.2	+	11	1404	c.1256C>T	c.(1255-1257)TCC>TTC	p.S419F	ZMYM1_uc001byn.2_Missense_Mutation_p.S419F|ZMYM1_uc010ohu.1_Missense_Mutation_p.S400F|ZMYM1_uc001byo.2_Missense_Mutation_p.S59F|ZMYM1_uc009vut.2_Missense_Mutation_p.S344F	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	419	Ser-rich.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCAATTGGTTCCAGTACAGAA	0.368													6	27					0	0	0	0	T	35578687	T	T	35578687	3	4	128	1	0	0	0	0	1	0	0	0	17766	855	30	2	1290	2	ZMYM1	1	35578687	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3368364	35578687	213671934	11	22625											
MACF1	23499	broad.mit.edu	37	chr1	39750825	39750825	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgatgtggaagaagagtgggGaaagctcatcatagagatgc	14	8	15	4	0	2	4	2	1	0	3	2	7	2	6	0	3	2	1	0	3	4	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:39750825G>A	uc010ois.1	+	13	1422	c.1217G>A	c.(1216-1218)GGA>GAA	p.G406E	MACF1_uc001cda.1_Missense_Mutation_p.G314E	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	406					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAGAGTGGGGAAAGCTCATC	0.458													14	68					0	0	0	0	A	39750825	A	A	39750825	3	1	128	1	0	0	0	0	1	0	0	0	9195	1174	41	2	1259	2	MACF1	1	39750825	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4172138	39750825	209499796	12	22626											
KIAA0754	643314	broad.mit.edu	37	chr1	39876389	39876389	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagagaggatagaagcttCtctcagtgaggtttcagaag	12	10	13	6	0	3	4	2	1	1	3	4	6	3	5	0	2	2	3	0	2	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:39876389C>T	uc009vvt.1	+	1	1214	c.452C>T	c.(451-453)TCT>TTT	p.S151F	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	15											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATAGAAGCTTCTCTCAGTGAG	0.468													6	115					0	0	0	0	T	39876389	T	T	39876389	3	4	128	1	0	0	0	0	1	0	0	0	8231	913	32	2	454	2	KIAA0754	1	39876389	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	125564	39876389	209374232	13	22627											
SLFNL1	200172	broad.mit.edu	37	chr1	41481844	41481844	+	Silent	SNP	C	T	T																															tgctgctggagctgctccttCtccatcatcagcgccttcat																								rs142166637		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:41481844C>T	uc001cgm.1	-	5	1378	c.1158G>A	c.(1156-1158)GAG>GAA	p.E386E	SLFNL1_uc009vwf.1_Silent_p.E338E|SLFNL1_uc001cgn.1_Silent_p.E327E|SLFNL1_uc009vwg.1_Silent_p.E386E	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	386	Potential.						ATP binding	p.E386E(1)		skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				GCTGCTCCTTCTCCATCATCA	0.637													14	94					0	0	0	0	T	41481844	T	T	41481844	2	4	128	1	0	0	0	0	0	0	0	1	14802	912	32	2		2	SLFNL1	1	41481844	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1605455	41481844	207768777	14	22628	47	2									
SLFNL1	200172	broad.mit.edu	37	chr1	41481853	41481853	+	Silent	SNP	C	T	T																															agctgctccttctccatcatCagcgccttcatcttctcttc																										TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:41481853C>T	uc001cgm.1	-	5	1369	c.1149G>A	c.(1147-1149)CTG>CTA	p.L383L	SLFNL1_uc009vwf.1_Silent_p.L335L|SLFNL1_uc001cgn.1_Silent_p.L324L|SLFNL1_uc009vwg.1_Silent_p.L383L	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	383	Potential.						ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				TCTCCATCATCAGCGCCTTCA	0.642													15	90					0	0	0	0	T	41481853	T	T	41481853	2	4	128	1	0	0	0	0	0	0	0	1	14802	813	29	2		2	SLFNL1	1	41481853	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	9	41481853	207768768	15	22629	47	2									
KIF2C	11004	broad.mit.edu	37	chr1	45221866	45221866	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaccaagcattctgctttGactttgcatttgatgaaaca	13	13	7	8	0	1	4	0	3	1	1	1	4	1	4	1	0	5	3	1	0	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:45221866G>C	uc001cmg.3	+	10	1049	c.934G>C	c.(934-936)GAC>CAC	p.D312H	KIF2C_uc010olb.1_Missense_Mutation_p.D271H|KIF2C_uc010olc.1_Missense_Mutation_p.D199H|KIF2C_uc001cmh.3_Missense_Mutation_p.D258H	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	312	Kinesin-motor.				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ATTCTGCTTTGACTTTGCATT	0.423													28	143					0	0	0	0	C	45221866	C	C	45221866	3	2	128	1	0	0	0	0	1	0	0	0	8338	1290	45	2	972	2	KIF2C	1	45221866	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3740013	45221866	204028755	16	22630											
CYP4A11	1579	broad.mit.edu	37	chr1	47398445	47398445	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtctcaccttgatcctcctGagaagggcaggaaagcgtgg	9	8	13	11	2	1	2	1	2	1	1	4	4	3	3	3	3	1	1	3	3	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:47398445G>C	uc001cqp.3	-	11	1403	c.1352C>G	c.(1351-1353)TCA>TGA	p.S451*	CYP4A11_uc001cqq.2_Nonsense_Mutation_p.S451*	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	451					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	TGATCCTCCTGAGAAGGGCAG	0.507													61	311					0	0	0	0	C	47398445	C	C	47398445	4	2	128	1	0	0	0	0	0	1	0	0	4200	1294	45	2	215	2	CYP4A11	1	47398445	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2176579	47398445	201852176	17	22631											
CMPK1	51727	broad.mit.edu	37	chr1	47840885	47840885	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagaattcagacctaccttCagtcaacaaagccaattatt	15	10	5	11	0	3	2	3	0	0	2	3	2	3	2	3	0	3	1	3	0	6	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:47840885C>T	uc001cri.2	+	5	714	c.565C>T	c.(565-567)CAG>TAG	p.Q189*	CMPK1_uc010omp.1_Nonsense_Mutation_p.Q140*|CMPK1_uc010omq.1_RNA	NM_016308	NP_057392	P30085	KCY_HUMAN	UMP-CMP kinase 1 isoform a	157					nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleus	ATP binding|cytidylate kinase activity|nucleoside phosphate kinase activity|uridine kinase activity			ovary(1)	1					Gemcitabine(DB00441)	GACCTACCTTCAGTCAACAAA	0.368													24	140					0	0	0	0	T	47840885	T	T	47840885	4	4	128	1	0	0	0	0	0	1	0	0	3595	827	29	2	583	2	CMPK1	1	47840885	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	442440	47840885	201409736	18	22632											
FAM159A	348378	broad.mit.edu	37	chr1	53108622	53108622	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgctctgctacctgttcatCagctctaagccccacacaaa	10	10	6	15	0	4	0	2	0	2	0	4	0	4	0	3	0	5	4	3	0	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:53108622C>T	uc001cuf.2	+	2	370	c.270C>T	c.(268-270)ATC>ATT	p.I90I	FAM159A_uc001cug.1_RNA|FAM159A_uc001cuh.2_RNA	NM_001042693	NP_001036158	Q6UWV7	F159A_HUMAN	hypothetical protein LOC348378	90	Helical; (Potential).					integral to membrane					0						ACCTGTTCATCAGCTCTAAGC	0.527													20	125					0	0	0	0	T	53108622	T	T	53108622	2	4	128	1	0	0	0	0	0	0	0	1	5496	816	29	2		2	FAM159A	1	53108622	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5267737	53108622	196141999	19	22633											
C1orf173	127254	broad.mit.edu	37	chr1	75038328	75038328	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatcttccttgcaaaggaaGgcttcctttgcaaggcttcc	9	12	8	12	0	1	0	0	0	1	0	4	1	4	1	3	3	2	4	3	3	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:75038328G>T	uc001dgg.2	-	14	3285	c.3066C>A	c.(3064-3066)GCC>GCA	p.A1022A		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1022	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TGCAAAGGAAGGCTTCCTTTG	0.502													17	95					0.000175454	0.000181495	1	0	T	75038328	T	T	75038328	2	4	128	1	0	0	0	0	0	0	0	1	2023	987	35	4		4	C1orf173	1	75038328	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	21929706	75038328	174212293	20	22634											
ASB17	127247	broad.mit.edu	37	chr1	76397847	76397847	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatctgtaaatccttggttCgtaacagtgatatccccact	10	14	7	10	1	1	2	0	2	1	0	4	2	3	2	3	1	1	3	3	1	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:76397847C>A	uc001dhe.1	-	1	270	c.130G>T	c.(130-132)GAA>TAA	p.E44*	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	44					intracellular signal transduction					ovary(1)	1						ATCCTTGGTTCGTAACAGTGA	0.398													34	132					1.414e-09	1.50266e-09	1	0	A	76397847	A	A	76397847	4	1	128	1	0	0	0	0	0	1	0	0	1023	893	31	3	769	3	ASB17	1	76397847	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1359519	76397847	172852774	21	22635											
PRKACB	5567	broad.mit.edu	37	chr1	84650847	84650847	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaaatgttttcacatctaaGaagaattggaaggttcaggt	14	13	10	4	0	3	3	2	1	1	2	3	4	3	4	0	3	0	2	0	3	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:84650847G>A	uc001djj.2	+	5	665	c.401G>A	c.(400-402)AGA>AAA	p.R134K	PRKACB_uc001djl.2_Missense_Mutation_p.R181K|PRKACB_uc010ort.1_Missense_Mutation_p.R141K|PRKACB_uc001djn.2_Missense_Mutation_p.R138K|PRKACB_uc010oru.1_Missense_Mutation_p.R122K|PRKACB_uc001djp.2_Missense_Mutation_p.R140K|PRKACB_uc001djq.2_Missense_Mutation_p.R104K|PRKACB_uc010orv.1_Missense_Mutation_p.R121K|PRKACB_uc001dji.2_Missense_Mutation_p.R134K|PRKACB_uc001djk.2_Missense_Mutation_p.R181K|PRKACB_uc009wcf.1_Missense_Mutation_p.R140K	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	134	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		TCACATCTAAGAAGAATTGGA	0.308													23	152					0	0	0	0	A	84650847	A	A	84650847	3	1	128	1	0	0	0	0	1	0	0	0	12560	942	33	2	610	2	PRKACB	1	84650847	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	8253000	84650847	164599774	22	22636											
RPF1	80135	broad.mit.edu	37	chr1	84948646	84948646	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgacaaccagcgagtgtatGatgaaaccacagtagaccct	14	8	9	10	1	0	4	0	3	0	1	0	5	0	4	3	0	3	2	3	0	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:84948646G>A	uc001djv.3	+	3	379	c.334G>A	c.(334-336)GAT>AAT	p.D112N		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	112					rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						GCGAGTGTATGATGAAACCAC	0.318													6	32					0	0	0	0	A	84948646	A	A	84948646	3	1	128	1	0	0	0	0	1	0	0	0	13611	1290	45	2	344	2	RPF1	1	84948646	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	297799	84948646	164301975	23	22637											
COL24A1	255631	broad.mit.edu	37	chr1	86313410	86313410	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaatttttccaggaggacCtctgcttccaacttctcctg	7	13	6	15	0	2	0	0	0	2	0	5	2	4	2	5	2	2	1	5	2	2	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:86313410C>G	uc001dlj.2	-	39	3442	c.3400G>C	c.(3400-3402)GGT>CGT	p.G1134R	COL24A1_uc001dli.2_Missense_Mutation_p.G270R|COL24A1_uc010osd.1_Missense_Mutation_p.G434R|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1134	Collagen-like 11.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CCAGGAGGACCTCTGCTTCCA	0.418													15	121					0	0	0	0	G	86313410	G	G	86313410	3	3	128	1	0	0	0	0	1	0	0	0	3698	681	24	4	1832	4	COL24A1	1	86313410	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1364764	86313410	162937211	24	22638											
CLCA1	1179	broad.mit.edu	37	chr1	86964330	86964330	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caagcaagtgtgtttcagcaGaacatcctcgggaggctcat	11	9	11	10	1	2	1	2	0	0	1	4	2	3	2	1	2	3	4	1	2	3	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:86964330G>C	uc001dlt.2	+	13	2318	c.2189G>C	c.(2188-2190)AGA>ACA	p.R730T		NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	730					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		TGTTTCAGCAGAACATCCTCG	0.423													13	94					0	0	0	0	C	86964330	C	C	86964330	3	2	128	1	0	0	0	0	1	0	0	0	3472	942	33	2	2239	2	CLCA1	1	86964330	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	650920	86964330	162286291	25	22639											
ABCA4	24	broad.mit.edu	37	chr1	94502326	94502326	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggtcctgaatcagaatcctCcgtgaccttcagaaaaatct	13	10	7	11	1	3	4	2	2	1	2	6	4	6	4	4	1	0	0	4	1	4	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:94502326C>T	uc001dqh.2	-	26	3936	c.3832G>A	c.(3832-3834)GAG>AAG	p.E1278K		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1278	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCAGAATCCTCCGTGACCTTC	0.438													31	125					0	0	0	0	T	94502326	T	T	94502326	3	4	128	1	0	0	0	0	1	0	0	0	34	864	30	2	3089	2	ABCA4	1	94502326	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	7537996	94502326	154748295	26	22640											
ABCA4	24	broad.mit.edu	37	chr1	94577116	94577116	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agcattcctgctgagggcatCgccttgttggggaaatggcc	7	10	14	10	1	0	1	0	1	0	0	2	2	1	2	3	4	2	4	3	4	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:94577116C>G	uc001dqh.2	-	3	284	c.180G>C	c.(178-180)GCG>GCC	p.A60A	ABCA4_uc010otn.1_Silent_p.A60A	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	60	Extracellular.		A -> T (in STGD1).|A -> E (in STGD1).|A -> V (in STGD1).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CTGAGGGCATCGCCTTGTTGG	0.512													10	52					0	0	0	0	G	94577116	G	G	94577116	2	3	128	1	0	0	0	0	0	0	0	1	34	871	31	3		3	ABCA4	1	94577116	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	74790	94577116	154673505	27	22641											
FAM102B	284611	broad.mit.edu	37	chr1	109154857	109154857	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcaggaaataccactcgcCgctgtttactggaaggctat	11	10	10	10	2	1	0	1	0	0	0	2	3	1	2	2	3	2	3	2	3	5	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:109154857C>T	uc010ouy.1	+	4	426	c.346C>T	c.(346-348)CGC>TGC	p.R116C		NM_001010883	NP_001010883	Q5T8I3	F102B_HUMAN	hypothetical protein LOC284611	116										large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		TACCACTCGCCGCTGTTTACT	0.363													24	72					0	0	0	0	T	109154857	T	T	109154857	3	4	128	1	0	0	0	0	1	0	0	0	5411	652	23	1	360	1	FAM102B	1	109154857	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	14577741	109154857	140095764	28	22642											
CSF1	1435	broad.mit.edu	37	chr1	110466425	110466425	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaccatccatctgccctgctCagagaccccccggagccagg	8	5	10	18	1	2	1	1	0	1	1	3	4	3	2	7	2	3	1	7	2	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:110466425C>G	uc001dyu.2	+	6	1595	c.1182C>G	c.(1180-1182)CTC>CTG	p.L394L	CSF1_uc001dyt.2_Intron|CSF1_uc001dyv.3_Intron|CSF1_uc001dyw.3_Silent_p.L394L	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	394	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTGCCCTGCTCAGAGACCCCC	0.642													9	39					0	0	0	0	G	110466425	G	G	110466425	2	3	128	1	0	0	0	0	0	0	0	1	3948	813	29	2		2	CSF1	1	110466425	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1311568	110466425	138784196	29	22643											
GOLPH3L	55204	broad.mit.edu	37	chr1	150634351	150634351	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagttgctttgatgtgtttCagagtttcatccagtaaaac	10	16	8	7	0	3	2	3	1	0	1	4	2	4	2	1	0	2	5	1	0	2	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:150634351C>T	uc001evj.2	-	4	586	c.369G>A	c.(367-369)CTG>CTA	p.L123L	GOLPH3L_uc010pci.1_Silent_p.L79L	NM_018178	NP_060648	Q9H4A5	GLP3L_HUMAN	Golgi phosphoprotein 3-like	123						Golgi cisterna membrane				ovary(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TGATGTGTTTCAGAGTTTCAT	0.388													17	95					0	0	0	0	T	150634351	T	T	150634351	2	4	128	1	0	0	0	0	0	0	0	1	6606	813	29	2		2	GOLPH3L	1	150634351	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	40167926	150634351	98616270	30	22644											
DCST1	149095	broad.mit.edu	37	chr1	155011959	155011959	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tacccaagatgctgggcaagGaaggcaggctctttgtcctg	9	9	13	10	0	1	1	0	0	1	1	2	2	2	2	2	4	2	4	2	4	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:155011959G>A	uc001fgn.1	+	5	439	c.343G>A	c.(343-345)GAA>AAA	p.E115K	DCST1_uc010per.1_Missense_Mutation_p.E140K|DCST1_uc010pes.1_Missense_Mutation_p.E90K	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	115	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GCTGGGCAAGGAAGGCAGGCT	0.612													5	97					0	0	0	0	A	155011959	A	A	155011959	3	1	128	1	0	0	0	0	1	0	0	0	4319	1175	41	2	357	2	DCST1	1	155011959	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4377608	155011959	94238662	31	22645											
FCRL3	115352	broad.mit.edu	37	chr1	157648586	157648586	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggccctgcctctgctgctagCctcccctgcagagtcgtctg	3	10	11	17	1	2	1	0	0	2	1	4	1	3	1	5	1	5	3	5	1	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:157648586C>T	uc001frb.2	-	15	2411	c.2119G>A	c.(2119-2121)GCT>ACT	p.A707T	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.A707T|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Missense_Mutation_p.A433T|FCRL3_uc001frc.1_Missense_Mutation_p.A707T	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	707	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CTGCTGCTAGCCTCCCCTGCA	0.468													12	56					0	0	0	0	T	157648586	T	T	157648586	3	4	128	1	0	0	0	0	1	0	0	0	5828	739	26	4	89	4	FCRL3	1	157648586	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2636627	157648586	91602035	32	22646											
FCRL3	115352	broad.mit.edu	37	chr1	157665912	157665912	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtatctccctgcatcactCtccttcacggtgagaacatg	9	12	7	13	1	4	1	2	1	2	1	6	2	4	1	2	1	2	2	2	1	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:157665912C>G	uc001frb.2	-	7	1342	c.1050G>C	c.(1048-1050)GAG>GAC	p.E350D	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.E350D|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Missense_Mutation_p.E76D|FCRL3_uc001frc.1_Missense_Mutation_p.E350D	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	350	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CTGCATCACTCTCCTTCACGG	0.512													9	64					0	0	0	0	G	157665912	G	G	157665912	3	3	128	1	0	0	0	0	1	0	0	0	5828	912	32	2	1190	2	FCRL3	1	157665912	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	17326	157665912	91584709	33	22647											
SDHC	6391	broad.mit.edu	37	chr1	161326611	161326611	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctctcatgtatcatacctGgaatgggatccgacacttgg	9	11	9	12	1	2	0	2	0	1	0	4	3	3	2	3	3	1	1	3	3	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:161326611G>A	uc001gag.2	+	5	416	c.386G>A	c.(385-387)TGG>TAG	p.W129*	SDHC_uc001gai.2_Intron|SDHC_uc001gaj.2_Nonsense_Mutation_p.W76*|SDHC_uc001gak.2_Intron|SDHC_uc001gah.2_Nonsense_Mutation_p.W95*	NM_003001	NP_002992	Q99643	C560_HUMAN	succinate dehydrogenase complex, subunit C	129	Helical; (By similarity).				respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II|plasma membrane succinate dehydrogenase complex	electron carrier activity|heme binding|succinate dehydrogenase activity				0	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Succinic acid(DB00139)	TATCATACCTGGAATGGGATC	0.463			Mis|N|F			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome				24	143					0	0	0	0	A	161326611	A	A	161326611	4	1	128	1	0	0	0	0	0	1	0	0	14031	1357	47	4	404	4	SDHC	1	161326611	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3660699	161326611	87924010	34	22648											
RGS4	5999	broad.mit.edu	37	chr1	163039306	163039306	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttgcaggtctgccggcttCttgcttgaggaggtaagatt	6	13	14	8	1	2	2	0	1	2	1	2	3	2	3	1	4	3	5	1	4	1	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:163039306C>G	uc009wuy.2	+	1	543	c.32C>G	c.(31-33)TCT>TGT	p.S11C	RGS4_uc001gcl.3_Missense_Mutation_p.S108C|RGS4_uc009wuz.2_Missense_Mutation_p.S11C|RGS4_uc009wva.2_5'Flank	NM_005613	NP_005604	P49798	RGS4_HUMAN	regulator of G-protein signaling 4 isoform 2	11					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3						CTGCCGGCTTCTTGCTTGAGG	0.438											OREG0013952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	42					0	0	0	0	G	163039306	G	G	163039306	3	3	128	1	0	0	0	0	1	0	0	0	13372	913	32	2	329	2	RGS4	1	163039306	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1712695	163039306	86211315	35	22649											
DUSP27	92235	broad.mit.edu	37	chr1	167095830	167095830	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgagaggctgctggagattGagaaggaggcttcccggagg	10	6	18	7	2	0	3	0	1	0	3	1	8	1	5	1	6	1	3	1	6	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:167095830G>C	uc001geb.1	+	5	1462	c.1462G>C	c.(1462-1464)GAG>CAG	p.E488Q		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	488					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GCTGGAGATTGAGAAGGAGGC	0.647													7	27					0	0	0	0	C	167095830	C	C	167095830	3	2	128	1	0	0	0	0	1	0	0	0	4846	1291	45	2	1480	2	DUSP27	1	167095830	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4056524	167095830	82154791	36	22650											
DUSP27	92235	broad.mit.edu	37	chr1	167097324	167097324	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttttccaaatcccagtcaGaggaacaggacacctcctcc	12	8	7	14	0	1	1	1	0	0	1	5	3	5	3	5	2	1	1	5	2	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:167097324G>A	uc001geb.1	+	5	2956	c.2956G>A	c.(2956-2958)GAG>AAG	p.E986K		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	986	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						ATCCCAGTCAGAGGAACAGGA	0.517													12	59					0	0	0	0	A	167097324	A	A	167097324	3	1	128	1	0	0	0	0	1	0	0	0	4846	943	33	2	2974	2	DUSP27	1	167097324	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1494	167097324	82153297	37	22651											
C1orf114	57821	broad.mit.edu	37	chr1	169390719	169390719	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagactgtgtcctgtgattaGatttcccattccctttactt	7	17	6	11	0	0	3	0	1	0	2	3	3	3	3	3	0	1	0	3	0	2	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:169390719G>C	uc001gga.1	-	3	1118	c.950C>G	c.(949-951)TCT>TGT	p.S317C	C1orf114_uc001gfz.1_Missense_Mutation_p.S317C|C1orf114_uc009wvq.1_Missense_Mutation_p.S317C|C1orf114_uc001ggb.2_Missense_Mutation_p.S317C|C1orf114_uc001ggc.1_Missense_Mutation_p.S317C	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	317											0	all_hematologic(923;0.208)					CCTGTGATTAGATTTCCCATT	0.458													21	97					0	0	0	0	C	169390719	C	C	169390719	3	2	128	1	0	0	0	0	1	0	0	0	1996	942	33	2	592	2	C1orf114	1	169390719	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2293395	169390719	79859902	38	22652											
SOAT1	6646	broad.mit.edu	37	chr1	179311274	179311274	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttgtaatgaaggcccactCatttgtcagagagaacgtgc	11	12	10	8	1	2	3	2	1	0	2	2	4	2	3	1	1	2	1	1	1	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:179311274C>T	uc001gml.2	+	8	869	c.806C>T	c.(805-807)TCA>TTA	p.S269L	SOAT1_uc010pni.1_Missense_Mutation_p.S204L|SOAT1_uc001gmm.2_Missense_Mutation_p.S211L|SOAT1_uc010pnj.1_Missense_Mutation_p.S5L|SOAT1_uc010pnk.1_Missense_Mutation_p.S204L	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	269					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	AAGGCCCACTCATTTGTCAGA	0.343													14	52					0	0	0	0	T	179311274	T	T	179311274	3	4	128	1	0	0	0	0	1	0	0	0	14974	838	29	2	832	2	SOAT1	1	179311274	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	9920555	179311274	69939347	39	22653											
QSOX1	5768	broad.mit.edu	37	chr1	180163447	180163447	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgagcagatggctgctgcctCcatgcaccgggtggggagtc	6	7	16	12	2	0	1	0	0	0	1	2	3	1	2	3	4	4	4	3	4	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:180163447C>G	uc001gnz.2	+	11	1463	c.1388C>G	c.(1387-1389)TCC>TGC	p.S463C	QSOX1_uc001gny.2_Missense_Mutation_p.S463C|QSOX1_uc001goa.2_Missense_Mutation_p.S463C|QSOX1_uc001goc.2_Missense_Mutation_p.S5C	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	463	ERV/ALR sulfhydryl oxidase.				cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						GCTGCTGCCTCCATGCACCGG	0.627													12	48					0	0	0	0	G	180163447	G	G	180163447	3	3	128	1	0	0	0	0	1	0	0	0	12948	855	30	2	1430	2	QSOX1	1	180163447	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	852173	180163447	69087174	40	22654											
RGS16	6004	broad.mit.edu	37	chr1	182569610	182569610	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgtggcagtctgcaggttCatcctcgtcagctcgtgggt	4	12	14	11	2	3	0	2	0	1	0	6	0	4	0	1	3	2	5	1	3	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:182569610C>T	uc001gpl.3	-	5	580	c.426G>A	c.(424-426)ATG>ATA	p.M142I		NM_002928	NP_002919	O15492	RGS16_HUMAN	regulator of G-protein signalling 16	142	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(1)	1						TCTGCAGGTTCATCCTCGTCA	0.592													10	64					0	0	0	0	T	182569610	T	T	182569610	3	4	128	1	0	0	0	0	1	0	0	0	13363	826	29	2	186	2	RGS16	1	182569610	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2406163	182569610	66681011	41	22655											
LAMC2	3918	broad.mit.edu	37	chr1	183209330	183209330	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgaatatggatgcagtacaGatggtgagttcctgttgctt	10	13	12	6	1	0	2	0	1	0	1	1	4	1	3	1	2	3	5	1	2	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:183209330G>C	uc001gqa.2	+	21	3539	c.3225G>C	c.(3223-3225)CAG>CAC	p.Q1075H	LAMC2_uc001gpz.3_Missense_Mutation_p.Q1075H|LAMC2_uc010poa.1_Missense_Mutation_p.Q775H	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	1075	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						ATGCAGTACAGATGGTGAGTT	0.473													22	81					0	0	0	0	C	183209330	C	C	183209330	3	2	128	1	0	0	0	0	1	0	0	0	8655	933	33	2	3307	2	LAMC2	1	183209330	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	639720	183209330	66041291	42	22656											
RGL1	23179	broad.mit.edu	37	chr1	183775568	183775568	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgtttaccatgtcaccctCaaaagagtccagattcaaca	13	10	6	12	0	3	2	3	0	0	2	4	2	4	2	3	0	2	2	3	0	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:183775568C>T	uc001gqo.2	+	2	244	c.87C>T	c.(85-87)CTC>CTT	p.L29L	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Silent_p.L64L|RGL1_uc010pog.1_Intron|RGL1_uc010poh.1_Intron|RGL1_uc010poi.1_Silent_p.L29L	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	29					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						ATGTCACCCTCAAAAGAGTCC	0.473													19	80					0	0	0	0	T	183775568	T	T	183775568	2	4	128	1	0	0	0	0	0	0	0	1	13341	813	29	2		2	RGL1	1	183775568	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	566238	183775568	65475053	43	22657											
RGL1	23179	broad.mit.edu	37	chr1	183853004	183853004	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagaattcacgtgcttctCagaagatctcgtggcagagc	11	9	11	10	2	3	4	2	0	2	4	5	4	3	4	0	1	3	3	0	1	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:183853004C>T	uc001gqo.2	+	6	852	c.695C>T	c.(694-696)TCA>TTA	p.S232L	RGL1_uc010pof.1_Missense_Mutation_p.S37L|RGL1_uc001gqm.2_Missense_Mutation_p.S267L|RGL1_uc010pog.1_Missense_Mutation_p.S230L|RGL1_uc010poh.1_Missense_Mutation_p.S230L|RGL1_uc010poi.1_Missense_Mutation_p.S232L	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	232	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						ACGTGCTTCTCAGAAGATCTC	0.483													25	111					0	0	0	0	T	183853004	T	T	183853004	3	4	128	1	0	0	0	0	1	0	0	0	13341	838	29	2	822	2	RGL1	1	183853004	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	77436	183853004	65397617	44	22658											
RNF2	6045	broad.mit.edu	37	chr1	185062311	185062311	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcgtgatgagtatgaagctCatcaagagagagtattagcc	13	10	12	6	1	2	5	2	3	0	2	3	6	2	5	1	0	2	3	1	0	5	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:185062311C>T	uc001grc.1	+	4	600	c.367C>T	c.(367-369)CAT>TAT	p.H123Y	RNF2_uc001grd.1_Intron|RNF2_uc001gre.1_RNA	NM_007212	NP_009143	Q99496	RING2_HUMAN	ring finger protein 2	123	Interaction with HIP2.				histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(1)	1		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		GTATGAAGCTCATCAAGAGAG	0.423													6	44					0	0	0	0	T	185062311	T	T	185062311	3	4	128	1	0	0	0	0	1	0	0	0	13537	826	29	2	377	2	RNF2	1	185062311	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1209307	185062311	64188310	45	22659											
PRG4	10216	broad.mit.edu	37	chr1	186275736	186275736	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actactacaacaaataaacaGacttcaactgatggaaaaga	21	7	5	8	0	1	3	1	1	0	2	1	4	1	4	0	1	5	0	0	1	9	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:186275736G>A	uc001gru.3	+	7	936	c.885G>A	c.(883-885)CAG>CAA	p.Q295Q	PRG4_uc001grt.3_Silent_p.Q254Q|PRG4_uc009wyl.2_Silent_p.Q202Q|PRG4_uc009wym.2_Silent_p.Q161Q|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	295					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CAAATAAACAGACTTCAACTG	0.368													32	174					0	0	0	0	A	186275736	A	A	186275736	2	1	128	1	0	0	0	0	0	0	0	1	12543	933	33	2		2	PRG4	1	186275736	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1213425	186275736	62974885	46	22660											
TPR	7175	broad.mit.edu	37	chr1	186315362	186315362	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcttttccaactgtgtctGaaattcagctgactctttta	8	18	5	10	0	4	2	1	2	3	0	5	2	5	2	1	0	2	1	1	0	3	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:186315362G>A	uc001grv.2	-	23	3298	c.3001C>T	c.(3001-3003)CAG>TAG	p.Q1001*		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1001	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		AACTGTGTCTGAAATTCAGCT	0.348			T	NTRK1	papillary thyroid								10	78					0	0	0	0	A	186315362	A	A	186315362	4	1	128	1	0	0	0	0	0	1	0	0	16483	1299	45	2	4206	2	TPR	1	186315362	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	39626	186315362	62935259	47	22661											
F13B	2165	broad.mit.edu	37	chr1	197031034	197031034	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accataacgcatgttctcttGaattttatacaataacttta	14	16	3	8	1	1	1	0	1	1	0	2	1	1	1	1	0	3	2	1	0	7	9			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:197031034G>C	uc001gtt.1	-	3	375	c.331C>G	c.(331-333)CAA>GAA	p.Q111E		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	111	Sushi 2.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ATGTTCTCTTGAATTTTATAC	0.373													6	35					0	0	0	0	C	197031034	C	C	197031034	3	2	128	1	0	0	0	0	1	0	0	0	5366	1299	45	2	1694	2	F13B	1	197031034	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	10715672	197031034	52219587	48	22662											
KIF14	9928	broad.mit.edu	37	chr1	200524573	200524573	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catggcattagttttcatttCtttggtaacctatagagaat	11	17	7	6	0	2	1	1	0	1	1	2	2	2	1	1	2	1	3	1	2	5	8			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:200524573C>G	uc010ppk.1	-	28	4802	c.4363G>C	c.(4363-4365)GAA>CAA	p.E1455Q	KIF14_uc010ppj.1_Missense_Mutation_p.E964Q	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1455	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding	p.E1455Q(1)		breast(3)|ovary(2)|skin(2)	7						GTTTTCATTTCTTTGGTAACC	0.259													8	34					0	0	0	0	G	200524573	G	G	200524573	3	3	128	1	0	0	0	0	1	0	0	0	8315	922	32	2	595	2	KIF14	1	200524573	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3493539	200524573	48726048	49	22663											
PLEKHA6	22874	broad.mit.edu	37	chr1	204197211	204197211	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggcccagcccctctcacCagacagcatgcggcccctgc	7	4	10	20	2	1	1	1	0	1	1	2	2	1	1	6	2	4	1	6	2	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:204197211C>T	uc001hau.2	-	21	3348	c.3031G>A	c.(3031-3033)GTG>ATG	p.V1011M		NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	1011										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			CCCCTCTCACCAGACAGCATG	0.647													7	28					0	0	0	0	T	204197211	T	T	204197211	3	4	128	1	0	0	0	0	1	0	0	0	12115	608	21	4	123	4	PLEKHA6	1	204197211	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3672638	204197211	45053410	50	22664											
PIGR	5284	broad.mit.edu	37	chr1	207112542	207112542	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacttgtagcgcccggagtCatcctggctcagctgggcaa	8	8	12	13	2	2	0	2	0	0	0	3	1	3	1	2	3	2	4	2	3	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:207112542C>T	uc001hez.2	-	3	494	c.310G>A	c.(310-312)GAC>AAC	p.D104N	PIGR_uc009xbz.2_Missense_Mutation_p.D104N	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	104	Ig-like V-type 1.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CGCCCGGAGTCATCCTGGCTC	0.582													9	27					0	0	0	0	T	207112542	T	T	207112542	3	4	128	1	0	0	0	0	1	0	0	0	11952	826	29	2	2020	2	PIGR	1	207112542	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2915331	207112542	42138079	51	22665											
KCNH1	3756	broad.mit.edu	37	chr1	210856787	210856787	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcgtttaaggccttgatgtCctccttcagctcgtgcctca	5	13	10	13	2	2	1	2	1	0	0	5	1	4	1	4	2	2	2	4	2	1	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:210856787C>T	uc001hib.2	-	11	2976	c.2806G>A	c.(2806-2808)GAC>AAC	p.D936N	KCNH1_uc001hic.2_Missense_Mutation_p.D909N	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	936	Cytoplasmic (Potential).|CAD (involved in subunit assembly) (By similarity).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GCCTTGATGTCCTCCTTCAGC	0.517													12	50					0	0	0	0	T	210856787	T	T	210856787	3	4	128	1	0	0	0	0	1	0	0	0	8070	855	30	2	167	2	KCNH1	1	210856787	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3744245	210856787	38393834	52	22666											
TP53BP2	7159	broad.mit.edu	37	chr1	223990037	223990037	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctggggaagatttccatCagatgaaaccttaggaaaga	14	10	11	6	0	1	4	1	1	0	3	2	6	2	6	2	3	2	1	2	3	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:223990037C>T	uc010pvb.1	-	9	1298	c.1006G>A	c.(1006-1008)GAT>AAT	p.D336N	TP53BP2_uc001hod.2_Missense_Mutation_p.D207N|TP53BP2_uc010puz.1_5'Flank|TP53BP2_uc010pva.1_5'UTR	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	330					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		AGATTTCCATCAGATGAAACC	0.458													7	49					0	0	0	0	T	223990037	T	T	223990037	3	4	128	1	0	0	0	0	1	0	0	0	16451	826	29	2	2438	2	TP53BP2	1	223990037	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	13133250	223990037	25260584	53	22667											
TP53BP2	7159	broad.mit.edu	37	chr1	223990487	223990487	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttccacagccggtccctCagctcattaacacgcttatc	8	12	5	16	2	3	0	2	0	1	0	6	0	5	0	3	1	3	2	3	1	2	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:223990487C>G	uc010pvb.1	-	8	1234	c.942G>C	c.(940-942)CTG>CTC	p.L314L	TP53BP2_uc001hod.2_Silent_p.L185L|TP53BP2_uc010puz.1_5'Flank|TP53BP2_uc010pva.1_5'Flank	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	308					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		GCCGGTCCCTCAGCTCATTAA	0.443													32	131					0	0	0	0	G	223990487	G	G	223990487	2	3	128	1	0	0	0	0	0	0	0	1	16451	813	29	2		2	TP53BP2	1	223990487	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	450	223990487	25260134	54	22668											
CAPN9	10753	broad.mit.edu	37	chr1	230907820	230907820	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaacccttggggccaggttGagtggaacgggtcgtggagc	7	7	19	8	2	0	1	0	1	0	0	1	4	0	4	2	7	3	1	2	7	2	2	rs145028426		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:230907820G>C	uc001htz.1	+	7	963	c.850G>C	c.(850-852)GAG>CAG	p.E284Q	CAPN9_uc009xfg.1_Missense_Mutation_p.E221Q|CAPN9_uc001hua.1_Missense_Mutation_p.E284Q	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	284	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				GGGCCAGGTTGAGTGGAACGG	0.572													9	58					0	0	0	0	C	230907820	C	C	230907820	3	2	128	1	0	0	0	0	1	0	0	0	2644	1291	45	2	876	2	CAPN9	1	230907820	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	6917333	230907820	18342801	55	22669											
KIAA1383	54627	broad.mit.edu	37	chr1	232942141	232942141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgacccaagaaaaaccgcccCctgcacaggctaaaatcacc	15	4	6	16	1	1	2	1	1	0	1	1	2	1	2	5	1	2	2	5	1	5	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:232942141C>T	uc001hvh.2	+	1	1504	c.1372C>T	c.(1372-1374)CCT>TCT	p.P458S		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	316										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				AAAACCGCCCCCTGCACAGGC	0.448													27	167					0	0	0	0	T	232942141	T	T	232942141	3	4	128	1	0	0	0	0	1	0	0	0	8267	623	22	4	1374	4	KIAA1383	1	232942141	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2034321	232942141	16308480	56	22670											
LYST	1130	broad.mit.edu	37	chr1	235915332	235915332	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcttgtttttgctattttGaagatatccaagcattacaa	11	17	5	8	0	1	2	0	1	1	1	2	2	2	2	2	0	3	3	2	0	6	8			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:235915332G>A	uc001hxj.2	-	27	7775	c.7600C>T	c.(7600-7602)CAA>TAA	p.Q2534*	LYST_uc009xga.1_Nonsense_Mutation_p.Q116*	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2534					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTGCTATTTTGAAGATATCCA	0.343									Chediak-Higashi_syndrome				8	26					0	0	0	0	A	235915332	A	A	235915332	4	1	128	1	0	0	0	0	0	1	0	0	9179	1299	45	2	3913	2	LYST	1	235915332	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2973191	235915332	13335289	57	22671											
LYST	1130	broad.mit.edu	37	chr1	235922480	235922480	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttaggtaatcaggtcggcGtgggcaggactcatccccag	8	9	13	11	2	2	0	2	0	0	0	4	1	3	1	2	5	0	2	2	5	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:235922480G>A	uc001hxj.2	-	23	6848	c.6673C>T	c.(6673-6675)CGC>TGC	p.R2225C	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2225					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCAGGTCGGCGTGGGCAGGAC	0.532									Chediak-Higashi_syndrome				12	55					0	0	0	0	A	235922480	A	A	235922480	3	1	128	1	0	0	0	0	1	0	0	0	9179	1145	40	1	4856	1	LYST	1	235922480	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7148	235922480	13328141	58	22672											
ZNF124	7678	broad.mit.edu	37	chr1	247322349	247322349	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtactgatcttcaatgctCtggtcttcccctttgtttcc	4	19	6	12	0	4	1	1	1	3	0	6	1	6	1	3	1	2	3	3	1	2	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:247322349C>G	uc001ick.2	-	3	316	c.177G>C	c.(175-177)CAG>CAC	p.Q59H	ZNF124_uc001ici.2_RNA|ZNF124_uc001icj.1_Missense_Mutation_p.Q59H	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			CTTCAATGCTCTGGTCTTCCC	0.318													7	28					0	0	0	0	G	247322349	G	G	247322349	3	3	128	1	0	0	0	0	1	0	0	0	17787	912	32	2	700	2	ZNF124	1	247322349	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	11399869	247322349	1928272	59	22673											
OR2M4	26245	broad.mit.edu	37	chr1	248402793	248402793	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgctgcccttttacctctatCctgcacagaaacatctgcat	9	13	5	14	0	2	1	0	0	2	1	3	1	3	1	3	0	6	3	3	0	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:248402793C>G	uc010pzh.1	+	1	563	c.563C>G	c.(562-564)TCC>TGC	p.S188C		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTACCTCTATCCTGCACAGAA	0.403													6	141					0	0	0	0	G	248402793	G	G	248402793	3	3	128	1	0	0	0	0	1	0	0	0	11066	855	30	2	565	2	OR2M4	1	248402793	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1080444	248402793	847828	60	22674											
MYT1L	23040	broad.mit.edu	37	chr2	1914020	1914020	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgctgggtacctgagcacGcggtccgaggcctggctgga	5	7	16	13	3	0	1	0	1	0	0	1	3	1	2	4	5	3	4	4	5	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:1914020G>A	uc002qxe.2	-	13	2636	c.1809C>T	c.(1807-1809)CGC>CGT	p.R603R	MYT1L_uc002qxd.2_Silent_p.R601R|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	603					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ACCTGAGCACGCGGTCCGAGG	0.637													5	37					0	0	0	0	A	1914020	A	A	1914020	2	1	128	1	0	0	0	0	0	0	0	1	10160	1074	38	1		1	MYT1L	2	1914020	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08		1914020	241285353	61	22675											
GRHL1	29841	broad.mit.edu	37	chr2	10136520	10136520	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accccatctttgaagggcttGatggaagctgtaagtaggat	11	11	12	7	0	1	2	0	2	1	0	1	4	1	4	2	3	1	4	2	3	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:10136520G>C	uc002raa.2	+	14	1839	c.1668G>C	c.(1666-1668)TTG>TTC	p.L556F	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.L367F|GRHL1_uc010yjb.1_Missense_Mutation_p.L405F	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	556					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TGAAGGGCTTGATGGAAGCTG	0.413													20	82					0	0	0	0	C	10136520	C	C	10136520	3	2	128	1	0	0	0	0	1	0	0	0	6802	1281	45	2	1722	2	GRHL1	2	10136520	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	8222500	10136520	233062853	62	22676											
ROCK2	9475	broad.mit.edu	37	chr2	11361348	11361348	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttctctatagtaggtaaatCcgatgaaaggcagctgattt	12	14	9	6	1	1	2	0	2	1	0	3	3	2	2	1	2	1	4	1	2	6	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:11361348C>G	uc002rbd.1	-	9	1684	c.1235G>C	c.(1234-1236)GGA>GCA	p.G412A		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	412	Interaction with NPM1.|AGC-kinase C-terminal.|Interaction with PPP1R12A.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		GTAGGTAAATCCGATGAAAGG	0.323													24	123					0	0	0	0	G	11361348	G	G	11361348	3	3	128	1	0	0	0	0	1	0	0	0	13583	855	30	2	3031	2	ROCK2	2	11361348	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1224828	11361348	231838025	63	22677											
E2F6	1876	broad.mit.edu	37	chr2	11605933	11605933	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttgatggggtctcggcaccGacggcgaaccgtctcctccg	5	8	14	14	6	2	1	0	1	2	0	5	3	3	1	4	4	1	2	4	4	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:11605933G>A	uc002rbh.2	-	1	365	c.73C>T	c.(73-75)CGG>TGG	p.R25W	E2F6_uc002rbe.2_5'UTR|E2F6_uc002rbf.2_5'UTR|E2F6_uc002rbg.2_5'UTR|E2F6_uc002rbi.2_5'UTR|E2F6_uc010yjl.1_RNA|E2F6_uc002rbj.1_RNA	NM_198256	NP_937987	O75461	E2F6_HUMAN	E2F transcription factor 6	25					negative regulation of transcription from RNA polymerase II promoter	MLL1 complex|transcription factor complex	DNA binding|transcription corepressor activity			skin(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.114)|OV - Ovarian serous cystadenocarcinoma(76;0.168)		TCTCGGCACCGACGGCGAACC	0.716													5	7					0	0	0	0	A	11605933	A	A	11605933	3	1	128	1	0	0	0	0	1	0	0	0	4893	1057	37	1	800	1	E2F6	2	11605933	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	244585	11605933	231593440	64	22678											
NBAS	51594	broad.mit.edu	37	chr2	15417101	15417101	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atactgcagcctttcgtgatCaaagccaccaatagtagggt	12	10	9	10	1	1	1	1	1	0	0	2	1	1	1	3	1	4	2	3	1	5	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:15417101C>T	uc002rcc.1	-	43	5289	c.5263G>A	c.(5263-5265)GAT>AAT	p.D1755N	NBAS_uc010exl.1_Missense_Mutation_p.D827N|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1755										ovary(2)|liver(1)|skin(1)	4						CTTTCGTGATCAAAGCCACCA	0.443													6	51					0	0	0	0	T	15417101	T	T	15417101	3	4	128	1	0	0	0	0	1	0	0	0	10239	826	29	2	1892	2	NBAS	2	15417101	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3811168	15417101	227782272	65	22679											
IFT172	26160	broad.mit.edu	37	chr2	27685974	27685974	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	taatacttgcatattcccggGatacttgatctgcaatctca	11	14	6	10	1	2	1	1	1	2	0	4	2	3	2	1	1	4	2	1	1	5	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:27685974G>T	uc002rku.2	-	19	2063	c.2012C>A	c.(2011-2013)TCC>TAC	p.S671Y		NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	671					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					ATATTCCCGGGATACTTGATC	0.438													8	58					5.4927e-09	5.82773e-09	1	0	T	27685974	T	T	27685974	3	4	128	1	0	0	0	0	1	0	0	0	7596	1174	41	2	3357	2	IFT172	2	27685974	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	12268873	27685974	215513399	66	22680											
LCLAT1	253558	broad.mit.edu	37	chr2	30756062	30756062	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagaaagaagtgtcattatCatgaaccatcggacaagaat	17	8	10	6	1	2	4	2	1	0	3	3	6	2	5	1	2	1	0	1	2	6	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:30756062C>G	uc002rnj.2	+	4	569	c.360C>G	c.(358-360)ATC>ATG	p.I120M	LCLAT1_uc010ymp.1_Translation_Start_Site|LCLAT1_uc002rnk.1_Missense_Mutation_p.I120M|LCLAT1_uc002rnl.2_Missense_Mutation_p.I82M|LCLAT1_uc010ymq.1_Missense_Mutation_p.I82M	NM_182551	NP_872357	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1 isoform 1	120					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			ovary(2)	2						GTGTCATTATCATGAACCATC	0.403													13	133					0	0	0	0	G	30756062	G	G	30756062	3	3	128	1	0	0	0	0	1	0	0	0	8717	816	29	2	370	2	LCLAT1	2	30756062	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3070088	30756062	212443311	67	22681											
BIRC6	57448	broad.mit.edu	37	chr2	32626362	32626362	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatggaactgacagaatatCttgctttgggtcggggagct	9	11	15	6	1	1	2	0	1	1	1	2	5	1	5	0	5	3	2	0	5	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:32626362C>G	uc010ezu.2	+	7	1300	c.1166C>G	c.(1165-1167)TCT>TGT	p.S389C		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	389					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GACAGAATATCTTGCTTTGGG	0.453													41	230					0	0	0	0	G	32626362	G	G	32626362	3	3	128	1	0	0	0	0	1	0	0	0	1441	913	32	2	1192	2	BIRC6	2	32626362	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1870300	32626362	210573011	68	22682											
CDKL4	344387	broad.mit.edu	37	chr2	39411779	39411779	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacatctgagaacttttcctCaagagtttcctgaaaaacaa	16	11	5	9	0	2	3	1	2	1	2	4	4	4	3	2	0	3	1	2	0	6	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:39411779C>G	uc002rrm.2	-	7	745	c.745G>C	c.(745-747)GAG>CAG	p.E249Q	CDKL4_uc010fal.1_Missense_Mutation_p.E249Q	NM_001009565	NP_001009565	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4	249	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			ovary(1)	1		all_hematologic(82;0.248)				AACTTTTCCTCAAGAGTTTCC	0.239													3	40					0	0	0	0	G	39411779	G	G	39411779	3	3	128	1	0	0	0	0	1	0	0	0	3171	835	29	2	210	2	CDKL4	2	39411779	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	6785417	39411779	203787594	69	22683											
LRPPRC	10128	broad.mit.edu	37	chr2	44116941	44116941	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcgtaacgctttagaaacaGatcatccaattttgtattct	12	15	6	8	2	2	2	1	0	1	2	3	2	3	2	1	0	3	3	1	0	5	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:44116941G>C	uc002rtr.2	-	37	4118	c.4060C>G	c.(4060-4062)CTG>GTG	p.L1354V		NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	1354	RNA-binding.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTTAGAAACAGATCATCCAAT	0.358													11	74					0	0	0	0	C	44116941	C	C	44116941	3	2	128	1	0	0	0	0	1	0	0	0	9015	933	33	2	132	2	LRPPRC	2	44116941	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4705162	44116941	199082432	70	22684											
C2orf34	79823	broad.mit.edu	37	chr2	44970813	44970813	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaactggaaggacattttGacattgttatgtgtgctgac	10	14	10	7	0	1	2	1	2	0	0	1	4	1	4	0	2	2	2	0	2	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:44970813G>A	uc002rum.2	+	8	780	c.676G>A	c.(676-678)GAC>AAC	p.D226N		NM_024766	NP_079042	Q7Z624	CMKMT_HUMAN	hypothetical protein LOC79823	226						cytoplasm	calmodulin-lysine N-methyltransferase activity				0		all_hematologic(82;0.0892)|Acute lymphoblastic leukemia(82;0.17)				AGGACATTTTGACATTGTTAT	0.343													7	26					0	0	0	0	A	44970813	A	A	44970813	3	1	128	1	0	0	0	0	1	0	0	0	2173	1290	45	2	706	2	C2orf34	2	44970813	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	853872	44970813	198228560	71	22685											
SOCS5	9655	broad.mit.edu	37	chr2	46986106	46986106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taaaaagtttggtagaactcGaagtggacttcaaaggagag	16	9	12	4	1	1	2	1	0	0	2	2	5	1	3	0	3	1	2	0	3	7	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:46986106G>A	uc002rvf.2	+	2	601	c.437G>A	c.(436-438)CGA>CAA	p.R146Q	SOCS5_uc010yoe.1_Missense_Mutation_p.R115Q|SOCS5_uc002rvg.2_Missense_Mutation_p.R146Q	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	146					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GGTAGAACTCGAAGTGGACTT	0.468													16	67					0	0	0	0	A	46986106	A	A	46986106	3	1	128	1	0	0	0	0	1	0	0	0	14981	1058	37	1	439	1	SOCS5	2	46986106	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2015293	46986106	196213267	72	22686											
SPTBN1	6711	broad.mit.edu	37	chr2	54876298	54876298	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtggtcgcagggtcccatGaactgggacaggactatgag	10	7	16	8	1	0	2	0	2	0	0	2	4	1	4	1	5	1	1	1	5	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:54876298G>A	uc002rxu.2	+	25	5422	c.5173G>A	c.(5173-5175)GAA>AAA	p.E1725K	SPTBN1_uc002rxx.2_Missense_Mutation_p.E1712K	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1725	Interaction with ANK2.|Spectrin 14.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGGGTCCCATGAACTGGGACA	0.552													12	64					0	0	0	0	A	54876298	A	A	54876298	3	1	128	1	0	0	0	0	1	0	0	0	15185	1291	45	2	5380	2	SPTBN1	2	54876298	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7890192	54876298	188323075	73	22687											
PNO1	56902	broad.mit.edu	37	chr2	68389791	68389791	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggacaaggatagttttggctGatgtgtaagtatctgatctt	10	15	12	4	0	2	2	0	2	2	0	2	4	2	4	0	3	0	4	0	3	4	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:68389791G>A	uc002seh.2	+	5	678	c.616G>A	c.(616-618)GAT>AAT	p.D206N		NM_020143	NP_064528	Q9NRX1	PNO1_HUMAN	partner of NOB1	206	KH.					nucleolus	RNA binding				0						AGTTTTGGCTGATGTGTAAGT	0.353													13	65					0	0	0	0	A	68389791	A	A	68389791	3	1	128	1	0	0	0	0	1	0	0	0	12216	1290	45	2	634	2	PNO1	2	68389791	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	13513493	68389791	174809582	74	22688											
HK2	3099	broad.mit.edu	37	chr2	75061710	75061710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtcgggccgcggcaggatGattgcctcgcatctgcttgc	4	9	14	14	5	1	1	0	1	1	0	3	2	1	2	3	3	3	3	3	3	0	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:75061710G>A	uc002snd.2	+	1	1929	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	1	Hydrophobic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GCGGCAGGATGATTGCCTCGC	0.677													6	42					0	0	0	0	A	75061710	A	A	75061710	3	1	128	1	0	0	0	0	1	0	0	0	7230	1290	45	2	5	2	HK2	2	75061710	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	6671919	75061710	168137663	75	22689											
VAMP5	10791	broad.mit.edu	37	chr2	85818887	85818887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgccagcagcaggcgaacGaggtgacggaaattatgcgt	11	6	16	8	4	0	1	0	1	0	0	0	4	0	2	1	4	5	2	1	4	3	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:85818887G>A	uc002spu.1	+	2	126	c.43G>A	c.(43-45)GAG>AAG	p.E15K		NM_006634	NP_006625	O95183	VAMP5_HUMAN	vesicle-associated membrane protein 5	15	v-SNARE coiled-coil homology.|Cytoplasmic (Potential).				cell differentiation|vesicle-mediated transport	endomembrane system					0						GCAGGCGAACGAGGTGACGGA	0.602													21	80					0	0	0	0	A	85818887	A	A	85818887	3	1	128	1	0	0	0	0	1	0	0	0	17184	1059	37	1	49	1	VAMP5	2	85818887	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	10757177	85818887	157380486	76	22690											
PROM2	150696	broad.mit.edu	37	chr2	95953210	95953210	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acgtggcctgggtgagagagGaggtgagtggggcctcagaa	9	6	20	6	1	1	4	1	2	0	2	1	6	1	5	2	6	0	0	2	6	1	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:95953210G>T	uc002suh.1	+	20	2375	c.2242G>T	c.(2242-2244)GAG>TAG	p.E748*	PROM2_uc002sui.2_Nonsense_Mutation_p.E748*|PROM2_uc002suj.2_Nonsense_Mutation_p.E402*|PROM2_uc002suk.2_Nonsense_Mutation_p.E748*|PROM2_uc002sul.2_Nonsense_Mutation_p.E274*|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	748	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GGTGAGAGAGGAGGTGAGTGG	0.642													5	40					0.000602214	0.000619073	1	0	T	95953210	T	T	95953210	4	4	128	1	0	0	0	0	0	1	0	0	12618	1175	41	2	2320	2	PROM2	2	95953210	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	10134323	95953210	147246163	77	22691											
AFF3	3899	broad.mit.edu	37	chr2	100203693	100203693	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtcttgaagagctgtctttCtctccctgggacttcttgat	6	16	9	10	0	4	3	0	2	4	1	6	4	5	4	1	1	1	1	1	1	1	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:100203693C>G	uc002tag.2	-	15	2750	c.2514G>C	c.(2512-2514)GAG>GAC	p.E838D	AFF3_uc002taf.2_Missense_Mutation_p.E863D|AFF3_uc010fiq.1_Missense_Mutation_p.E838D|AFF3_uc010yvr.1_Missense_Mutation_p.E991D|AFF3_uc002tah.1_Missense_Mutation_p.E863D	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	838					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						AGCTGTCTTTCTCTCCCTGGG	0.453													32	148					0	0	0	0	G	100203693	G	G	100203693	3	3	128	1	0	0	0	0	1	0	0	0	358	912	32	2	1206	2	AFF3	2	100203693	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	4250483	100203693	142995680	78	22692											
NMS	129521	broad.mit.edu	37	chr2	101096984	101096984	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggactgctgcagtggacttCaccaagaaggtacacaagag	13	6	13	9	0	1	2	1	0	0	2	1	4	1	4	1	3	3	3	1	3	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:101096984C>T	uc002tan.1	+	7	370	c.363C>T	c.(361-363)TTC>TTT	p.F121F		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	121					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						CAGTGGACTTCACCAAGAAGG	0.562													8	52					0	0	0	0	T	101096984	T	T	101096984	2	4	128	1	0	0	0	0	0	0	0	1	10556	825	29	2		2	NMS	2	101096984	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	893291	101096984	142102389	79	22693											
C1QL2	165257	broad.mit.edu	37	chr2	119915802	119915802	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcggcgcctcggggcgccGcctgcagcagcagcggcacg	4	2	18	17	8	0	0	0	0	0	0	1	0	0	0	3	4	4	4	3	4	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:119915802G>T	uc002tlo.2	-	1	670	c.44C>A	c.(43-45)GCG>GAG	p.A15E		NM_182528	NP_872334	Q7Z5L3	C1QL2_HUMAN	complement component 1, q subcomponent-like 2	15						collagen				pancreas(1)	1						TCGGGGCGCCGCCTGCAGCAG	0.741										HNSCC(49;0.14)			4	5					1.23904e-05	1.28977e-05	1	0	T	119915802	T	T	119915802	3	4	128	1	0	0	0	0	1	0	0	0	1968	1087	38	3	827	3	C1QL2	2	119915802	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	18818818	119915802	123283571	80	22694											
CNTNAP5	129684	broad.mit.edu	37	chr2	124783248	124783248	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggattctttaccacggctGaccagcgttttgactttgct	7	15	9	10	2	1	2	0	2	1	0	1	3	1	3	2	2	3	3	2	2	1	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:124783248G>A	uc002tno.2	+	1	385	c.21G>A	c.(19-21)CTG>CTA	p.L7L	CNTNAP5_uc010flu.2_Silent_p.L7L	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	7					cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TACCACGGCTGACCAGCGTTT	0.547													8	71					0	0	0	0	A	124783248	A	A	124783248	2	1	128	1	0	0	0	0	0	0	0	1	3665	1277	45	2		2	CNTNAP5	2	124783248	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4867446	124783248	118416125	81	22695											
DARS	1615	broad.mit.edu	37	chr2	136740989	136740989	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtttttcttgtgattgtatCattgaagatattccatatct	9	20	7	5	0	3	3	1	2	2	1	4	3	4	3	1	1	0	2	1	1	4	9			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:136740989C>G	uc002tux.1	-	2	286	c.102G>C	c.(100-102)ATG>ATC	p.M34I	DARS_uc010fnj.1_Intron	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	34					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	GTGATTGTATCATTGAAGATA	0.299													2	8					0	0	0	0	G	136740989	G	G	136740989	3	3	128	1	0	0	0	0	1	0	0	0	4258	826	29	2	1463	2	DARS	2	136740989	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	11957741	136740989	106458384	82	22696											
NMI	9111	broad.mit.edu	37	chr2	152132175	152132175	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattttcattttagaaacttCtacataaacctggaaaatga	16	14	5	6	0	2	2	1	1	1	1	2	4	2	3	1	1	3	0	1	1	7	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:152132175C>G	uc002txi.2	-	6	787	c.457G>C	c.(457-459)GAA>CAA	p.E153Q	NMI_uc010zbx.1_3'UTR	NM_004688	NP_004679	Q13287	NMI_HUMAN	N-myc and STAT interactor	153					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity				0				BRCA - Breast invasive adenocarcinoma(221;0.0571)		TTAGAAACTTCTACATAAACC	0.343													6	73					0	0	0	0	G	152132175	G	G	152132175	3	3	128	1	0	0	0	0	1	0	0	0	10551	922	32	2	478	2	NMI	2	152132175	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	15391186	152132175	91067198	83	22697											
PKP4	8502	broad.mit.edu	37	chr2	159530188	159530188	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatccttgctctctacctaGatcatctctgaaagtggtga	10	14	7	10	0	3	3	1	2	2	1	6	3	4	3	2	1	2	1	2	1	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:159530188G>A	uc002tzv.2	+	18	3185	c.2925_splice	c.e18-1	p.R975_splice	PKP4_uc002tzw.2_Splice_Site_p.R975_splice|PKP4_uc002tzx.2_Splice_Site_p.R632_splice|PKP4_uc002uaa.2_Splice_Site_p.R827_splice|uc002uab.1_Intron|PKP4_uc002uac.2_Splice_Site_p.R156_splice|PKP4_uc002uad.2_Splice_Site|PKP4_uc002uae.1_Splice_Site_p.R62_splice	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a						cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						TCTCTACCTAGATCATCTCTG	0.478										HNSCC(62;0.18)			11	53					0	0	0	0	A	159530188	A	A	159530188	5	1	128	1	0	0	0	0	0	0	1	0	12042	956	33	2	2990	2	PKP4	2	159530188	Splice_Site	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7398013	159530188	83669185	84	22698											
WDSUB1	151525	broad.mit.edu	37	chr2	160092614	160092614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatttggtgtaagtaccgctGaaggaagaacaagatttgtc	13	12	11	5	1	0	3	0	1	0	2	1	4	0	4	1	2	2	3	1	2	7	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:160092614G>A	uc002uaj.3	-	11	1510	c.1361C>T	c.(1360-1362)TCA>TTA	p.S454L	WDSUB1_uc002uak.3_Missense_Mutation_p.S454L|WDSUB1_uc002ual.3_Missense_Mutation_p.S454L|WDSUB1_uc002uam.3_Missense_Mutation_p.S407L|WDSUB1_uc010foo.2_Missense_Mutation_p.S362L	NM_152528	NP_689741	Q8N9V3	WSDU1_HUMAN	WD repeat, sterile alpha motif and U-box domain	454	U-box.					ubiquitin ligase complex	ubiquitin-protein ligase activity				0						AAGTACCGCTGAAGGAAGAAC	0.333													10	36					0	0	0	0	A	160092614	A	A	160092614	3	1	128	1	0	0	0	0	1	0	0	0	17409	1294	45	2	73	2	WDSUB1	2	160092614	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	562426	160092614	83106759	85	22699											
ITGB6	3694	broad.mit.edu	37	chr2	160958212	160958212	+	RNA	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgcattaacatttcatatCagtgaaacagacttttttca	14	15	5	7	0	3	2	3	1	0	1	3	2	3	2	0	0	3	1	0	0	3	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:160958212C>T	uc002ubg.2	-	1		c.47G>A						P18564	ITB6_HUMAN	Homo sapiens cDNA: FLJ23083 fis, clone LNG06541, highly similar to IR2005735 Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 2005735.						cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						CATTTCATATCAGTGAAACAG	0.303													9	34					0	0	0	0	T	160958212	T	T	160958212	1	4	128	0	1	0	0	0	0	0	0	0	7938	841	29	2		2	ITGB6	2	160958212	RNA	SNP	C	TCGA-CR-6481-01A-11D-1870-08	865598	160958212	82241161	86	22700											
SCN3A	6328	broad.mit.edu	37	chr2	166011139	166011139	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaccaggacaaaaaatatCatgtatgttttcccagcagc	15	10	7	9	0	1	1	1	1	0	0	2	2	2	2	2	1	2	3	2	1	5	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:166011139C>T	uc002ucx.2	-	11	1695	c.1203G>A	c.(1201-1203)ATG>ATA	p.M401I	SCN3A_uc002ucy.2_Missense_Mutation_p.M401I|SCN3A_uc002ucz.2_Missense_Mutation_p.M401I|SCN3A_uc002uda.1_Missense_Mutation_p.M270I|SCN3A_uc002udb.1_Missense_Mutation_p.M270I	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	401	Helical; Name=S6 of repeat I; (Potential).			M -> T (in Ref. 4; AAC29514/AAC29515).		voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CAAAAAATATCATGTATGTTT	0.413													17	65					0	0	0	0	T	166011139	T	T	166011139	3	4	128	1	0	0	0	0	1	0	0	0	13983	826	29	2	4871	2	SCN3A	2	166011139	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5052927	166011139	77188234	87	22701											
SCN7A	6332	broad.mit.edu	37	chr2	167262119	167262119	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctttgaataggtgacttttCcttagctttgtcaaaatagg	10	16	9	6	0	1	2	1	2	0	0	2	2	2	2	1	2	1	2	1	2	6	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:167262119C>A	uc002udu.1	-	25	5147	c.5020G>T	c.(5020-5022)GAA>TAA	p.E1674*		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1674					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.E1674K(1)		large_intestine(1)	1						GGTGACTTTTCCTTAGCTTTG	0.353													38	189					3.09479e-21	3.34257e-21	1	0	A	167262119	A	A	167262119	4	1	128	1	0	0	0	0	0	1	0	0	13988	864	30	2	32	2	SCN7A	2	167262119	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1250980	167262119	75937254	88	22702											
ABCB11	8647	broad.mit.edu	37	chr2	169869909	169869909	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcgtagtcaataaaaacatCtgtcattgtgccaaaaatga	16	11	7	7	1	3	1	2	1	1	0	4	1	3	1	1	0	2	1	1	0	7	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:169869909C>G	uc002ueo.1	-	5	388	c.262G>C	c.(262-264)GAT>CAT	p.D88H		NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	88	ABC transmembrane type-1 1.|Extracellular (Potential).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	ATAAAAACATCTGTCATTGTG	0.423													34	192					0	0	0	0	G	169869909	G	G	169869909	3	3	128	1	0	0	0	0	1	0	0	0	42	913	32	2	3799	2	ABCB11	2	169869909	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2607790	169869909	73329464	89	22703											
TTN	7273	broad.mit.edu	37	chr2	179497295	179497295	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgtgcttatcttcagcttCaaacatgtattttgcttcat	8	19	6	8	0	4	0	3	0	1	0	4	0	4	0	0	0	4	4	0	0	3	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:179497295C>G	uc010zfg.1	-	184	35958	c.35734G>C	c.(35734-35736)GAA>CAA	p.E11912Q	TTN_uc010zfh.1_Missense_Mutation_p.E5607Q|TTN_uc010zfi.1_Missense_Mutation_p.E5540Q|TTN_uc010zfj.1_Missense_Mutation_p.E5415Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12839							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCAGCTTCAAACATGTAT	0.348													25	104					0	0	0	0	G	179497295	G	G	179497295	3	3	128	1	0	0	0	0	1	0	0	0	16803	835	29	2	64767	2	TTN	2	179497295	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	9627386	179497295	63702078	90	22704											
TTN	7273	broad.mit.edu	37	chr2	179497313	179497313	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaaacatgtattttgcttCatcttcaaaagcagctgact	12	15	5	9	0	4	1	3	1	1	0	4	1	4	1	0	0	4	4	0	0	4	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:179497313C>T	uc010zfg.1	-	184	35940	c.35716G>A	c.(35716-35718)GAA>AAA	p.E11906K	TTN_uc010zfh.1_Missense_Mutation_p.E5601K|TTN_uc010zfi.1_Missense_Mutation_p.E5534K|TTN_uc010zfj.1_Missense_Mutation_p.E5409K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12833							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTTTGCTTCATCTTCAAAA	0.373													30	144					0	0	0	0	T	179497313	T	T	179497313	3	4	128	1	0	0	0	0	1	0	0	0	16803	835	29	2	64785	2	TTN	2	179497313	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	18	179497313	63702060	91	22705											
TTN	7273	broad.mit.edu	37	chr2	179547472	179547472	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgttcatactcccgctcctCgtattcttcatattggtcat	6	17	5	13	3	4	0	3	0	1	0	8	0	6	0	2	1	1	3	2	1	3	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:179547472C>T	uc010zfg.1	-	132	29538	c.29314G>A	c.(29314-29316)GAG>AAG	p.E9772K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E6433K|TTN_uc010fre.1_Missense_Mutation_p.E619K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10699							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCGCTCCTCGTATTCTTCA	0.358													30	216					0	0	0	0	T	179547472	T	T	179547472	3	4	128	1	0	0	0	0	1	0	0	0	16803	893	31	1	71395	1	TTN	2	179547472	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	50159	179547472	63651901	92	22706											
DUSP19	142679	broad.mit.edu	37	chr2	183960237	183960237	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taggtttcctgatgaattctGaacaaacctcatttaccagt	12	14	6	9	0	2	3	1	3	1	0	3	3	3	3	3	1	3	1	3	1	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:183960237G>A	uc002upd.2	+	4	880	c.505G>A	c.(505-507)GAA>AAA	p.E169K	DUSP19_uc010frp.2_Missense_Mutation_p.E118K|DUSP19_uc010zfr.1_RNA|DUSP19_uc002upe.2_3'UTR	NM_080876	NP_543152	Q8WTR2	DUS19_HUMAN	dual specificity phosphatase 19 isoform 1	169	Tyrosine-protein phosphatase.				JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|positive regulation of JNK cascade|positive regulation of JUN kinase activity	cytoplasm	JUN kinase phosphatase activity|MAP-kinase scaffold activity|mitogen-activated protein kinase kinase kinase binding|protein kinase activator activity|protein kinase inhibitor activity|protein tyrosine phosphatase activity			ovary(4)|pancreas(1)	5						GATGAATTCTGAACAAACCTC	0.388													19	130					0	0	0	0	A	183960237	A	A	183960237	3	1	128	1	0	0	0	0	1	0	0	0	4840	1291	45	2	519	2	DUSP19	2	183960237	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4412765	183960237	59239136	93	22707											
DUSP19	142679	broad.mit.edu	37	chr2	183960345	183960345	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtacatatcaagagggcaaaGaaagcaataagtgtgacaga	19	6	11	5	0	1	4	1	1	0	3	1	4	1	4	0	1	2	3	0	1	7	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:183960345G>A	uc002upd.2	+	4	988	c.613G>A	c.(613-615)GAA>AAA	p.E205K	DUSP19_uc010frp.2_Missense_Mutation_p.E154K|DUSP19_uc010zfr.1_RNA|DUSP19_uc002upe.2_3'UTR	NM_080876	NP_543152	Q8WTR2	DUS19_HUMAN	dual specificity phosphatase 19 isoform 1	205					JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|positive regulation of JNK cascade|positive regulation of JUN kinase activity	cytoplasm	JUN kinase phosphatase activity|MAP-kinase scaffold activity|mitogen-activated protein kinase kinase kinase binding|protein kinase activator activity|protein kinase inhibitor activity|protein tyrosine phosphatase activity			ovary(4)|pancreas(1)	5						AGAGGGCAAAGAAAGCAATAA	0.398													10	50					0	0	0	0	A	183960345	A	A	183960345	3	1	128	1	0	0	0	0	1	0	0	0	4840	943	33	2	627	2	DUSP19	2	183960345	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	108	183960345	59239028	94	22708											
ZNF804A	91752	broad.mit.edu	37	chr2	185800988	185800988	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcaatgtgcagagacaaaGaaactgttcaaactcaagag	18	6	10	7	0	2	3	2	0	0	3	2	4	2	3	0	1	3	3	0	1	5	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:185800988G>C	uc002uph.2	+	4	1459	c.865G>C	c.(865-867)GAA>CAA	p.E289Q		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	289						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CAGAGACAAAGAAACTGTTCA	0.363													9	52					0	0	0	0	C	185800988	C	C	185800988	3	2	128	1	0	0	0	0	1	0	0	0	18237	943	33	2	879	2	ZNF804A	2	185800988	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1840643	185800988	57398385	95	22709											
ZSWIM2	151112	broad.mit.edu	37	chr2	187702178	187702178	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagttttaatggtgcaaactCtttcctgcacagaggacatt	11	13	8	9	0	1	1	0	0	1	1	2	2	2	2	1	2	3	3	1	2	2	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:187702178C>G	uc002upu.1	-	5	638	c.598G>C	c.(598-600)GAG>CAG	p.E200Q		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	200					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			GGTGCAAACTCTTTCCTGCAC	0.383													10	85					0	0	0	0	G	187702178	G	G	187702178	3	3	128	1	0	0	0	0	1	0	0	0	18308	922	32	2	1323	2	ZSWIM2	2	187702178	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1901190	187702178	55497195	96	22710											
MPP4	58538	broad.mit.edu	37	chr2	202550741	202550741	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaggggttcaaaatctttCtgagctatcgtgtcatgggc	10	12	12	7	1	4	2	2	1	2	1	5	2	4	2	0	3	1	2	0	3	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:202550741C>T	uc002uyk.3	-	6	601	c.393G>A	c.(391-393)CAG>CAA	p.Q131Q	MPP4_uc010ftj.2_Silent_p.Q131Q|MPP4_uc010zhq.1_Silent_p.Q131Q|MPP4_uc010zhr.1_Silent_p.Q131Q|MPP4_uc010zhs.1_Intron|MPP4_uc002uyj.3_Intron|MPP4_uc010zht.1_Silent_p.Q104Q|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Silent_p.Q131Q|MPP4_uc002uym.1_Intron|MPP4_uc002uyn.2_Intron	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	131	L27 2.					cytoplasm	protein binding				0						CAAAATCTTTCTGAGCTATCG	0.493													29	137					0	0	0	0	T	202550741	T	T	202550741	2	4	128	1	0	0	0	0	0	0	0	1	9789	912	32	2		2	MPP4	2	202550741	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	14848563	202550741	40648632	97	22711											
ICOS	29851	broad.mit.edu	37	chr2	204820605	204820605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctatacaacttggaccattCtcatgccaactattacttct	11	15	3	12	0	3	0	1	0	3	0	4	1	3	1	2	1	5	0	2	1	6	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:204820605C>T	uc002vam.2	+	2	372	c.305C>T	c.(304-306)TCT>TTT	p.S102F	ICOS_uc010zip.1_Missense_Mutation_p.S102F|ICOS_uc010fua.2_Missense_Mutation_p.S102F	NM_012092	NP_036224	Q9Y6W8	ICOS_HUMAN	inducible T-cell co-stimulator precursor	102	Ig-like V-type.|Extracellular (Potential).				immune response|T cell costimulation	extracellular region					0						TTGGACCATTCTCATGCCAAC	0.358													9	69					0	0	0	0	T	204820605	T	T	204820605	3	4	128	1	0	0	0	0	1	0	0	0	7525	913	32	2	311	2	ICOS	2	204820605	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2269864	204820605	38378768	98	22712											
ERBB4	2066	broad.mit.edu	37	chr2	212566850	212566850	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagggactggaactgtagaGaggtgatgccctgttgcttg	8	11	15	7	0	1	2	1	1	0	1	1	5	1	4	1	3	3	3	1	3	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:212566850G>C	uc002veg.1	-	12	1429	c.1331C>G	c.(1330-1332)TCT>TGT	p.S444C	ERBB4_uc002veh.1_Missense_Mutation_p.S444C|ERBB4_uc010zji.1_Missense_Mutation_p.S444C|ERBB4_uc010zjj.1_Missense_Mutation_p.S444C|ERBB4_uc010fut.1_Missense_Mutation_p.S444C	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	444	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GAACTGTAGAGAGGTGATGCC	0.458										TSP Lung(8;0.080)			13	83					0	0	0	0	C	212566850	C	C	212566850	3	2	128	1	0	0	0	0	1	0	0	0	5233	942	33	2	2663	2	ERBB4	2	212566850	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7746245	212566850	30632523	99	22713											
TNS1	7145	broad.mit.edu	37	chr2	218749773	218749773	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcacctttgaaagcatcatCaaggtcctccttcccaaaga	12	9	6	14	1	2	2	2	1	0	1	5	2	5	2	4	1	1	2	4	1	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:218749773C>G	uc002vgt.2	-	14	1254	c.856G>C	c.(856-858)GAT>CAT	p.D286H	TNS1_uc002vgr.2_Missense_Mutation_p.D286H|TNS1_uc002vgs.2_Missense_Mutation_p.D286H|TNS1_uc010zjv.1_Missense_Mutation_p.D286H|TNS1_uc010fvj.1_Missense_Mutation_p.D354H|TNS1_uc010fvk.1_Missense_Mutation_p.D411H|TNS1_uc002vgu.3_Missense_Mutation_p.D317H|TNS1_uc010fvi.1_5'UTR	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	286	C2 tensin-type.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		AAAGCATCATCAAGGTCCTCC	0.577													4	52					0	0	0	0	G	218749773	G	G	218749773	3	3	128	1	0	0	0	0	1	0	0	0	16409	826	29	2	4431	2	TNS1	2	218749773	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	6182923	218749773	24449600	100	22714											
ATG9A	79065	broad.mit.edu	37	chr2	220085575	220085575	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaccctccaagaggcagcCgagagaaatgagagggaacc	14	2	12	13	1	0	3	0	1	0	3	1	7	1	4	5	2	2	1	5	2	3	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:220085575C>T	uc002vke.1	-	15	2594	c.2408G>A	c.(2407-2409)CGG>CAG	p.R803Q	ABCB6_uc002vkc.1_5'Flank|ABCB6_uc010fwe.1_5'Flank|ABCB6_uc010zku.1_5'Flank|ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Missense_Mutation_p.R803Q	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	803	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGAGGCAGCCGAGAGAAATG	0.577													11	44					0	0	0	0	T	220085575	T	T	220085575	3	4	128	1	0	0	0	0	1	0	0	0	1104	652	23	1	119	1	ATG9A	2	220085575	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1335802	220085575	23113798	101	22715											
COL4A4	1286	broad.mit.edu	37	chr2	227958967	227958967	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcctggaagcccaggaaGaccaggaaatccttgtggcc	10	8	11	12	0	1	1	0	0	1	1	3	4	2	4	5	4	1	0	5	4	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:227958967G>C	uc010zlt.1	-	20	1897	c.1243C>G	c.(1243-1245)CTT>GTT	p.L415V		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	415	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		AGCCCAGGAAGACCAGGAAAT	0.502													5	33					0	0	0	0	C	227958967	C	C	227958967	3	2	128	1	0	0	0	0	1	0	0	0	3708	942	33	2	3945	2	COL4A4	2	227958967	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7873392	227958967	15240406	102	22716											
COL4A3	1285	broad.mit.edu	37	chr2	228109061	228109061	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggacttccaggactcaCgggttccaaaggtgtaaggg	10	8	13	10	1	1	0	1	0	0	0	4	2	4	2	3	5	0	2	3	5	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:228109061C>T	uc002vom.1	+	4	422	c.260C>T	c.(259-261)ACG>ATG	p.T87M	COL4A3_uc002von.1_Missense_Mutation_p.T87M|COL4A3_uc002voo.1_Missense_Mutation_p.T87M|COL4A3_uc002vop.1_Missense_Mutation_p.T87M|uc002voq.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	87	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CCAGGACTCACGGGTTCCAAA	0.378													13	73					0	0	0	0	T	228109061	T	T	228109061	3	4	128	1	0	0	0	0	1	0	0	0	3706	536	19	1	274	1	COL4A3	2	228109061	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	150094	228109061	15090312	103	22717											
GIGYF2	26058	broad.mit.edu	37	chr2	233671258	233671258	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcgggctattttactatgtCtttattggtgaagagagcgt	8	15	13	5	2	1	2	0	1	1	1	1	3	1	2	0	3	2	1	0	3	5	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:233671258C>G	uc002vti.3	+	17	2034	c.1697C>G	c.(1696-1698)TCT>TGT	p.S566C	GIGYF2_uc010zmj.1_Missense_Mutation_p.S566C|GIGYF2_uc002vtg.2_Missense_Mutation_p.S560C|GIGYF2_uc002vtj.3_Missense_Mutation_p.S587C|GIGYF2_uc002vtk.3_Missense_Mutation_p.S566C|GIGYF2_uc002vth.3_Missense_Mutation_p.S560C|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.S397C	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	566	GYF.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TTTACTATGTCTTTATTGGTG	0.438													33	147					0	0	0	0	G	233671258	G	G	233671258	3	3	128	1	0	0	0	0	1	0	0	0	6415	913	32	2	1817	2	GIGYF2	2	233671258	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5562197	233671258	9528115	104	22718											
NEU2	4759	broad.mit.edu	37	chr2	233899032	233899032	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actgaccacgggaggacctgGagctcccccagagacctcac	10	4	11	16	1	1	2	1	1	0	1	2	6	2	5	5	3	1	1	5	3	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:233899032G>A	uc010zmn.1	+	2	408	c.408G>A	c.(406-408)TGG>TGA	p.W136*		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	136	BNR 1.						exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		GGAGGACCTGGAGCTCCCCCA	0.637													10	37					0	0	0	0	A	233899032	A	A	233899032	4	1	128	1	0	0	0	0	0	1	0	0	10396	1183	41	2	414	2	NEU2	2	233899032	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	227774	233899032	9300341	105	22719											
SH3BP4	23677	broad.mit.edu	37	chr2	235950502	235950502	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaagccctgctggaccccccGctggagctcaacagtgacag	10	5	11	15	1	1	1	1	1	0	0	1	3	1	3	4	2	4	3	4	2	2	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:235950502G>A	uc002vvp.2	+	4	1482	c.1089G>A	c.(1087-1089)CCG>CCA	p.P363P	SH3BP4_uc010fym.2_Silent_p.P363P|SH3BP4_uc002vvq.2_Silent_p.P363P	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	363					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		TGGACCCCCCGCTGGAGCTCA	0.597													6	45					0	0	0	0	A	235950502	A	A	235950502	2	1	128	1	0	0	0	0	0	0	0	1	14311	1074	38	1		1	SH3BP4	2	235950502	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2051470	235950502	7248871	106	22720											
GADL1	339896	broad.mit.edu	37	chr3	30885930	30885930	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtgccaatcccaagaaaaGaggctgccttcttcatagag	13	8	9	11	0	2	3	1	0	1	3	3	3	3	3	3	1	2	1	3	1	5	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:30885930G>C	uc003cep.2	-	7	727	c.680C>G	c.(679-681)TCT>TGT	p.S227C	GADL1_uc003ceq.1_Missense_Mutation_p.S227C	NM_207359	NP_997242	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	227					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	CCCAAGAAAAGAGGCTGCCTT	0.433													35	150					0	0	0	0	C	30885930	C	C	30885930	3	2	128	1	0	0	0	0	1	0	0	0	6219	942	33	2	921	2	GADL1	3	30885930	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08		30885930	167136500	107	22721											
CLASP2	23122	broad.mit.edu	37	chr3	33585011	33585011	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatcgtggtgttggtcttgtCaaaggactccccatggaact	8	12	12	9	1	2	0	1	0	1	0	4	3	3	2	2	4	1	1	2	4	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:33585011C>T	uc003cfu.2	-	31	3672	c.3318G>A	c.(3316-3318)TTG>TTA	p.L1106L	CLASP2_uc003cfs.2_Silent_p.L313L|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Silent_p.L706L	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1115										ovary(3)|central_nervous_system(1)	4						TTGGTCTTGTCAAAGGACTCC	0.393													13	80					0	0	0	0	T	33585011	T	T	33585011	2	4	128	1	0	0	0	0	0	0	0	1	3470	825	29	2		2	CLASP2	3	33585011	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2699081	33585011	164437419	108	22722											
SCN5A	6331	broad.mit.edu	37	chr3	38645426	38645426	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcagtgatgtgtggtggCtctcgctctcccccgctgtg	3	11	13	14	2	2	1	0	1	2	0	4	1	2	1	3	2	1	4	3	2	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:38645426C>T	uc003cio.2	-	12	1861	c.1667G>A	c.(1666-1668)AGC>AAC	p.S556N	SCN5A_uc003cin.2_Missense_Mutation_p.S556N|SCN5A_uc003cil.3_Missense_Mutation_p.S556N|SCN5A_uc010hhi.2_Missense_Mutation_p.S556N|SCN5A_uc010hhk.2_Missense_Mutation_p.S556N|SCN5A_uc011ayr.1_Missense_Mutation_p.S556N|SCN5A_uc010hhj.1_Missense_Mutation_p.S167N	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	556					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGTGTGGTGGCTCTCGCTCTC	0.642													7	41					0	0	0	0	T	38645426	T	T	38645426	3	4	128	1	0	0	0	0	1	0	0	0	13987	797	28	4	4451	4	SCN5A	3	38645426	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5060415	38645426	159377004	109	22723											
ULK4	54986	broad.mit.edu	37	chr3	41973352	41973352	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atacctttgactctacttttCatgcttttcttcaggacatt	8	19	4	10	0	4	1	2	1	2	0	4	2	4	2	1	1	3	1	1	1	2	9			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:41973352C>T	uc003ckv.3	-	5	726	c.525G>A	c.(523-525)ATG>ATA	p.M175I	ULK4_uc003ckw.2_Missense_Mutation_p.M175I|ULK4_uc003ckx.1_Missense_Mutation_p.M175I	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	175	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CTCTACTTTTCATGCTTTTCT	0.423													22	185					0	0	0	0	T	41973352	T	T	41973352	3	4	128	1	0	0	0	0	1	0	0	0	17046	826	29	2	3434	2	ULK4	3	41973352	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3327926	41973352	156049078	110	22724											
CELSR3	1951	broad.mit.edu	37	chr3	48669702	48669702	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaggccaaccaggacactGagtgtggaggccacctgtac	12	5	13	11	0	0	2	0	1	0	1	0	4	0	4	4	4	2	1	4	4	3	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:48669702G>A	uc003cuf.1	-	41	10776	c.10776C>T	c.(10774-10776)CTC>CTT	p.L3592L	SLC26A6_uc003cug.2_Silent_p.L166L|SLC26A6_uc003cuh.2_Silent_p.L187L|SLC26A6_uc010hke.2_Silent_p.L38L|SLC26A6_uc003cuk.2_Intron|SLC26A6_uc003cui.2_Silent_p.L187L|SLC26A6_uc003cuj.2_Silent_p.L187L|SLC26A6_uc011bbp.1_Intron	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCAGGACACTGAGTGTGGAGG	0.602													15	55					0	0	0	0	A	48669702	A	A	48669702	2	1	128	1	0	0	0	0	0	0	0	1	3238	1277	45	2		2	CELSR3	3	48669702	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	6696350	48669702	149352728	111	22725											
QARS	5859	broad.mit.edu	37	chr3	49136368	49136368	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgggtgcaaagggaacctGatggaagcctttggtctcat	11	10	13	7	0	1	1	1	1	1	0	2	3	1	3	2	4	3	1	2	4	4	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:49136368G>C	uc003cvx.2	-	19	1818	c.1813C>G	c.(1813-1815)CAG>GAG	p.Q605E	QARS_uc011bcc.1_Missense_Mutation_p.Q58E|QARS_uc011bcd.1_Missense_Mutation_p.Q460E|QARS_uc003cvy.2_Missense_Mutation_p.Q460E|QARS_uc011bce.1_Missense_Mutation_p.Q594E	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	605					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AAGGGAACCTGATGGAAGCCT	0.517													12	50					0	0	0	0	C	49136368	C	C	49136368	3	2	128	1	0	0	0	0	1	0	0	0	12936	1299	45	2	538	2	QARS	3	49136368	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	466666	49136368	148886062	112	22726											
MON1A	84315	broad.mit.edu	37	chr3	49947847	49947847	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacacgggcgtccaggcctCgccctcgcgaaaggacgagg	8	3	15	15	6	0	0	0	0	0	0	3	3	1	1	3	4	0	1	3	4	1	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:49947847C>T	uc003cxz.2	-	4	1501	c.1375G>A	c.(1375-1377)GAG>AAG	p.E459K	MON1A_uc003cya.2_Missense_Mutation_p.E297K|MON1A_uc003cyb.2_Missense_Mutation_p.E297K	NM_032355	NP_115731	Q86VX9	MON1A_HUMAN	MON1 homolog A isoform a	362							protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GTCCAGGCCTCGCCCTCGCGA	0.597													6	44					0	0	0	0	T	49947847	T	T	49947847	3	4	128	1	0	0	0	0	1	0	0	0	9751	893	31	1	595	1	MON1A	3	49947847	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	811479	49947847	148074583	113	22727											
HEMK1	51409	broad.mit.edu	37	chr3	50608743	50608743	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagtgagtacatcgtggctCatgtccttggagccaaaaca	11	9	10	11	1	1	1	1	1	0	0	3	2	2	2	3	2	3	2	3	2	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:50608743C>T	uc003dau.2	+	2	504	c.208C>T	c.(208-210)CAT>TAT	p.H70Y	C3orf18_uc003dat.2_5'Flank|HEMK1_uc003dav.2_Missense_Mutation_p.H70Y|HEMK1_uc003daw.2_Missense_Mutation_p.H70Y	NM_016173	NP_057257	Q9Y5R4	HEMK1_HUMAN	HemK methyltransferase family member 1	70					DNA methylation		DNA binding|N-methyltransferase activity|protein methyltransferase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000283)|KIRC - Kidney renal clear cell carcinoma(197;0.0179)|Kidney(197;0.0212)		CATCGTGGCTCATGTCCTTGG	0.522													5	39					0	0	0	0	T	50608743	T	T	50608743	3	4	128	1	0	0	0	0	1	0	0	0	7090	826	29	2	210	2	HEMK1	3	50608743	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	660896	50608743	147413687	114	22728											
PCBP4	57060	broad.mit.edu	37	chr3	51992917	51992917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgatcttgatatgtgcccctGacatctgccggatctcgctg	6	12	10	13	3	3	2	0	2	3	0	4	4	3	3	3	1	2	1	3	1	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:51992917G>A	uc003dcd.1	-	11	1208	c.812C>T	c.(811-813)TCA>TTA	p.S271L	PCBP4_uc003dcb.1_Missense_Mutation_p.S237L|PCBP4_uc003dcc.1_Missense_Mutation_p.S292L|PCBP4_uc003dce.1_Silent_p.V272V|PCBP4_uc003dcf.1_Missense_Mutation_p.S271L|PCBP4_uc003dcg.1_Missense_Mutation_p.S237L|PCBP4_uc003dch.1_Missense_Mutation_p.S271L|PCBP4_uc003dci.1_Missense_Mutation_p.S111L|PCBP4_uc003dcj.1_Missense_Mutation_p.S271L|PCBP4_uc003dck.1_Missense_Mutation_p.S228L|PCBP4_uc003dcl.1_Missense_Mutation_p.S271L	NM_033010	NP_127503	P57723	PCBP4_HUMAN	poly(rC) binding protein 4 isoform c	271	KH 3.					cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		ATGTGCCCCTGACATCTGCCG	0.612													21	95					0	0	0	0	A	51992917	A	A	51992917	3	1	128	1	0	0	0	0	1	0	0	0	11557	1294	45	2	407	2	PCBP4	3	51992917	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1384174	51992917	146029513	115	22729											
DUSP7	1849	broad.mit.edu	37	chr3	52087966	52087966	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcacctaccaatgaagctGatggcctcagggaagaactg	13	6	11	11	0	1	3	1	2	0	1	1	4	1	4	3	2	4	2	3	2	5	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:52087966G>C	uc003dct.2	-	2	1021	c.942C>G	c.(940-942)ATC>ATG	p.I314M	DUSP7_uc010hma.2_Missense_Mutation_p.I314M	NM_001947	NP_001938	Q16829	DUS7_HUMAN	dual specificity phosphatase 7	314	Tyrosine-protein phosphatase.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CAATGAAGCTGATGGCCTCAG	0.612													11	62					0	0	0	0	C	52087966	C	C	52087966	3	2	128	1	0	0	0	0	1	0	0	0	4852	1280	45	2	325	2	DUSP7	3	52087966	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	95049	52087966	145934464	116	22730											
CACNA1D	776	broad.mit.edu	37	chr3	53531326	53531326	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcccaaactatgagcacctCtgcacccccacctgtaggat	10	8	7	16	0	1	1	0	1	1	0	1	2	1	2	5	1	4	3	5	1	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:53531326C>G	uc003dgv.3	+	2	378	c.215C>G	c.(214-216)TCT>TGT	p.S72C	CACNA1D_uc003dgu.3_Missense_Mutation_p.S72C|CACNA1D_uc003dgy.3_Missense_Mutation_p.S72C	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	72	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ATGAGCACCTCTGCACCCCCA	0.547													4	74					0	0	0	0	G	53531326	G	G	53531326	3	3	128	1	0	0	0	0	1	0	0	0	2553	913	32	2	221	2	CACNA1D	3	53531326	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1443360	53531326	144491104	117	22731											
ERC2	26059	broad.mit.edu	37	chr3	56173588	56173588	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggcagtaagtgactctttGagcacttcaatgtgttgctt	8	16	10	7	0	2	2	1	2	1	0	2	2	2	2	0	1	2	5	0	1	2	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:56173588G>C	uc003dhr.1	-	6	1678	c.1422C>G	c.(1420-1422)CTC>CTG	p.L474L		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	474	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTGACTCTTTGAGCACTTCAA	0.428													11	48					0	0	0	0	C	56173588	C	C	56173588	2	2	128	1	0	0	0	0	0	0	0	1	5235	1277	45	2		2	ERC2	3	56173588	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2642262	56173588	141848842	118	22732											
EPHA3	2042	broad.mit.edu	37	chr3	89259517	89259517	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acacggtacccatggactccCagtccctggtggaggttaga	9	8	12	12	1	0	1	0	0	0	1	2	3	2	3	3	5	1	2	3	5	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:89259517C>T	uc003dqy.2	+	3	886	c.661C>T	c.(661-663)CAG>TAG	p.Q221*	EPHA3_uc003dqx.1_Nonsense_Mutation_p.Q221*|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	221	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CATGGACTCCCAGTCCCTGGT	0.478										TSP Lung(6;0.00050)			18	137					0	0	0	0	T	89259517	T	T	89259517	4	4	128	1	0	0	0	0	0	1	0	0	5192	595	21	4	671	4	EPHA3	3	89259517	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	33085929	89259517	108762913	119	22733											
DIRC2	84925	broad.mit.edu	37	chr3	122545833	122545833	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacttgttgttccagctccCaatgggacatcacctcttct	7	13	6	15	0	3	0	1	0	2	0	5	1	5	1	4	1	1	3	4	1	1	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:122545833C>T	uc003efw.3	+	3	763	c.624C>T	c.(622-624)CCC>CCT	p.P208P	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Silent_p.P46P	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	208					transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		TTCCAGCTCCCAATGGGACAT	0.458													22	125					0	0	0	0	T	122545833	T	T	122545833	2	4	128	1	0	0	0	0	0	0	0	1	4556	581	21	4		4	DIRC2	3	122545833	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	33286316	122545833	75476597	120	22734											
MYLK	4638	broad.mit.edu	37	chr3	123419491	123419491	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggctgtgcaccttcctctCttcctcagacacagtctttg	5	13	9	14	0	3	1	1	0	2	1	6	1	5	1	3	2	1	2	3	2	0	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:123419491C>T	uc003ego.2	-	18	3106	c.2824G>A	c.(2824-2826)GAG>AAG	p.E942K	MYLK_uc011bjw.1_Missense_Mutation_p.E942K|MYLK_uc003egp.2_Missense_Mutation_p.E873K|MYLK_uc003egq.2_Missense_Mutation_p.E942K|MYLK_uc003egr.2_Missense_Mutation_p.E873K|MYLK_uc003egs.2_Missense_Mutation_p.E766K|MYLK_uc003egt.2_Missense_Mutation_p.E133K	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	942	Actin-binding (calcium/calmodulin- sensitive) (By similarity).|5 X 28 AA approximate tandem repeats.|1-3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ACCTTCCTCTCTTCCTCAGAC	0.587													11	70					0	0	0	0	T	123419491	T	T	123419491	3	4	128	1	0	0	0	0	1	0	0	0	10109	922	32	2	2988	2	MYLK	3	123419491	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	873658	123419491	74602939	121	22735											
TMCC1	23023	broad.mit.edu	37	chr3	129389903	129389903	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttggcaagcttcaagtattCagcaacgttgtcgtcccggg	8	11	12	10	3	2	0	2	0	0	0	4	0	3	0	1	2	3	6	1	2	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:129389903C>T	uc003emz.3	-	5	1282	c.781G>A	c.(781-783)GAA>AAA	p.E261K	TMCC1_uc003emy.3_5'UTR|TMCC1_uc011blc.1_Missense_Mutation_p.E82K|TMCC1_uc010htg.2_Missense_Mutation_p.E147K	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	261	Potential.					integral to membrane				skin(1)	1						TTCAAGTATTCAGCAACGTTG	0.498													45	214					0	0	0	0	T	129389903	T	T	129389903	3	4	128	1	0	0	0	0	1	0	0	0	16058	835	29	2	1192	2	TMCC1	3	129389903	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5970412	129389903	68632527	122	22736											
RAB6B	51560	broad.mit.edu	37	chr3	133553479	133553479	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagagccgacgccacacgtcGaaaaagctggaaagatgaag	16	4	12	9	4	0	3	0	1	0	2	1	6	0	4	2	1	2	1	2	1	5	1	rs147187493		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:133553479G>A	uc003epy.2	-	7	883	c.502C>T	c.(502-504)CGA>TGA	p.R168*	RAB6B_uc011blu.1_Nonsense_Mutation_p.R155*	NM_016577	NP_057661	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	168					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			pancreas(1)	1						GCCACACGTCGAAAAAGCTGG	0.522													16	70					0	0	0	0	A	133553479	A	A	133553479	4	1	128	1	0	0	0	0	0	1	0	0	13017	1066	37	1	132	1	RAB6B	3	133553479	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4163576	133553479	64468951	123	22737											
A4GNT	51146	broad.mit.edu	37	chr3	137843367	137843367	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaatctttgggggtgtaaGaaggatatgttcagacacct	13	12	11	5	0	2	2	1	0	1	2	2	3	2	3	1	3	0	2	1	3	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:137843367G>A	uc003ers.2	-	3	964	c.762C>T	c.(760-762)TTC>TTT	p.F254F		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	254	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						GGGGGTGTAAGAAGGATATGT	0.493													21	73					0	0	0	0	A	137843367	A	A	137843367	2	1	128	1	0	0	0	0	0	0	0	1	7	933	33	2		2	A4GNT	3	137843367	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4289888	137843367	60179063	124	22738											
CLSTN2	64084	broad.mit.edu	37	chr3	140277609	140277609	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagacctgctgcccagtttGaaagtgccaggggagtgacc	9	7	15	10	0	0	3	0	2	0	1	0	5	0	4	4	3	3	2	4	3	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:140277609G>C	uc003etn.2	+	12	2141	c.1951G>C	c.(1951-1953)GAA>CAA	p.E651Q		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	651	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TGCCCAGTTTGAAAGTGCCAG	0.582										HNSCC(16;0.037)			8	50					0	0	0	0	C	140277609	C	C	140277609	3	2	128	1	0	0	0	0	1	0	0	0	3577	1291	45	2	1997	2	CLSTN2	3	140277609	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2434242	140277609	57744821	125	22739											
ATP1B3	483	broad.mit.edu	37	chr3	141626075	141626075	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtaggtctgatccaacttCgtatgcagggtacattgaag	11	11	11	8	1	1	2	0	2	1	0	3	2	2	2	1	2	3	4	1	2	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:141626075C>T	uc003eug.1	+	3	479	c.305C>T	c.(304-306)TCG>TTG	p.S102L	ATP1B3_uc011bne.1_RNA|ATP1B3_uc003euh.1_Missense_Mutation_p.S88L	NM_001679	NP_001670	P54709	AT1B3_HUMAN	Na+/K+ -ATPase beta 3 subunit	102	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity				0						GATCCAACTTCGTATGCAGGG	0.343													8	52					0	0	0	0	T	141626075	T	T	141626075	3	4	128	1	0	0	0	0	1	0	0	0	1136	893	31	1	315	1	ATP1B3	3	141626075	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1348466	141626075	56396355	126	22740											
PLOD2	5352	broad.mit.edu	37	chr3	145789109	145789109	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagtgtaactggtgcaatGaactcccggataaaatgaag	14	10	10	7	1	1	2	1	2	0	0	2	3	2	3	1	2	3	2	1	2	6	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:145789109G>A	uc003evs.1	-	17	2393	c.1887C>T	c.(1885-1887)TTC>TTT	p.F629F	PLOD2_uc003evq.1_Silent_p.F310F|PLOD2_uc011bnm.1_Silent_p.F595F|PLOD2_uc003evr.1_Silent_p.F650F	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	629					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	CTGGTGCAATGAACTCCCGGA	0.418													9	77					0	0	0	0	A	145789109	A	A	145789109	2	1	128	1	0	0	0	0	0	0	0	1	12157	1281	45	2		2	PLOD2	3	145789109	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4163034	145789109	52233321	127	22741											
AADAC	13	broad.mit.edu	37	chr3	151545802	151545802	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatatgatctcttaagagatGatggactcatgtatgtcacc	13	13	8	7	0	3	3	2	2	1	1	4	5	3	4	1	1	0	1	1	1	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:151545802G>A	uc003eze.2	+	5	1132	c.1042G>A	c.(1042-1044)GAT>AAT	p.D348N		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	348	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CTTAAGAGATGATGGACTCAT	0.468													13	87					0	0	0	0	A	151545802	A	A	151545802	3	1	128	1	0	0	0	0	1	0	0	0	10	1290	45	2	1060	2	AADAC	3	151545802	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	5756693	151545802	46476628	128	22742											
MME	4311	broad.mit.edu	37	chr3	154860103	154860103	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgaacctacaaggagtccaGaaatgctttccgcaaggtga	13	7	10	11	2	0	2	0	1	0	1	2	4	2	3	4	2	3	2	4	2	5	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:154860103G>C	uc010hvr.1	+	12	1383	c.1172G>C	c.(1171-1173)AGA>ACA	p.R391T	MME_uc003fab.1_Missense_Mutation_p.R391T|MME_uc003fac.1_Missense_Mutation_p.R391T|MME_uc003fad.1_Missense_Mutation_p.R391T|MME_uc003fae.1_Missense_Mutation_p.R391T	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	391	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	AAGGAGTCCAGAAATGCTTTC	0.393													14	87					0	0	0	0	C	154860103	C	C	154860103	3	2	128	1	0	0	0	0	1	0	0	0	9698	942	33	2	1214	2	MME	3	154860103	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3314301	154860103	43162327	129	22743											
PLCH1	23007	broad.mit.edu	37	chr3	155199669	155199669	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accacaccctgattgtacttGagttttaaaggagaagcaag	14	10	9	8	0	0	3	0	2	0	1	0	4	0	3	2	1	2	3	2	1	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:155199669G>C	uc011bok.1	-	23	4447	c.4170C>G	c.(4168-4170)CTC>CTG	p.L1390L	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.L1352L	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1390					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GATTGTACTTGAGTTTTAAAG	0.418													6	75					0	0	0	0	C	155199669	C	C	155199669	2	2	128	1	0	0	0	0	0	0	0	1	12092	1277	45	2		2	PLCH1	3	155199669	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	339566	155199669	42822761	130	22744											
MECOM	2122	broad.mit.edu	37	chr3	168834418	168834418	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaaggaagacgtagtgctGaacatttgtccacagtcttt	11	14	9	7	1	1	2	0	1	1	1	2	3	2	3	1	1	2	2	1	1	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:168834418G>C	uc003ffi.3	-	7	947	c.678C>G	c.(676-678)TTC>TTG	p.F226L	MECOM_uc010hwk.1_Missense_Mutation_p.F249L|MECOM_uc003ffj.3_Missense_Mutation_p.F291L|MECOM_uc011bpi.1_Missense_Mutation_p.F227L|MECOM_uc003ffn.3_Missense_Mutation_p.F226L|MECOM_uc003ffk.2_Missense_Mutation_p.F226L|MECOM_uc003ffl.2_Missense_Mutation_p.F386L|MECOM_uc011bpj.1_Missense_Mutation_p.F414L|MECOM_uc011bpk.1_Missense_Mutation_p.F216L|MECOM_uc010hwn.2_Missense_Mutation_p.F414L	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	226	Interaction with MAPK9, SMAD3 and probably SUV39H1.|C2H2-type 7.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						ACGTAGTGCTGAACATTTGTC	0.438													14	126					0	0	0	0	C	168834418	C	C	168834418	3	2	128	1	0	0	0	0	1	0	0	0	9475	1281	45	2	2517	2	MECOM	3	168834418	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	13634749	168834418	29188012	131	22745											
SAMD7	344658	broad.mit.edu	37	chr3	169644598	169644598	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgggggcagagatgtcgtcGactcaggaaaaatacaggga	13	6	15	7	2	1	1	1	0	0	1	3	5	1	3	0	4	1	1	0	4	3	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:169644598G>A	uc003fgd.2	+	6	815	c.548G>A	c.(547-549)CGA>CAA	p.R183Q	SAMD7_uc003fge.2_Missense_Mutation_p.R183Q|SAMD7_uc011bpo.1_Missense_Mutation_p.R84Q	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	183										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AGATGTCGTCGACTCAGGAAA	0.478													10	75					0	0	0	0	A	169644598	A	A	169644598	3	1	128	1	0	0	0	0	1	0	0	0	13889	1058	37	1	562	1	SAMD7	3	169644598	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	810180	169644598	28377832	132	22746											
KLHL24	54800	broad.mit.edu	37	chr3	183368194	183368194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagaggatcttggggtgcGtgattccccagcaactaagc	10	8	13	10	1	1	2	0	1	1	1	2	4	2	3	2	3	4	1	2	3	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:183368194G>A	uc003flv.2	+	3	345	c.50G>A	c.(49-51)CGT>CAT	p.R17H	KLHL24_uc003flw.2_Missense_Mutation_p.R17H|KLHL24_uc003flx.2_Missense_Mutation_p.R17H	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	17						axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CTTGGGGTGCGTGATTCCCCA	0.408													7	59					0	0	0	0	A	183368194	A	A	183368194	3	1	128	1	0	0	0	0	1	0	0	0	8418	1145	40	1	52	1	KLHL24	3	183368194	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	13723596	183368194	14654236	133	22747											
ECE2	9718	broad.mit.edu	37	chr3	183996310	183996310	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggctctttctgccctctCgggattactacttaaacaga	8	13	8	12	1	3	1	0	0	3	1	4	2	3	2	1	2	4	1	1	2	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:183996310C>A	uc003fni.3	+	7	1173	c.1135C>A	c.(1135-1137)CGG>AGG	p.R379R	ECE2_uc011brg.1_Silent_p.R307R|ECE2_uc011brh.1_Silent_p.R232R|ECE2_uc003fnl.3_Silent_p.R307R|ECE2_uc003fnm.3_Silent_p.R261R|ECE2_uc003fnk.3_Silent_p.R232R|ECE2_uc011bri.1_Silent_p.R294R|ECE2_uc010hxv.2_Intron	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	379	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCTGCCCTCTCGGGATTACTA	0.552													21	113					7.45023e-12	7.98152e-12	1	0	A	183996310	A	A	183996310	2	1	128	1	0	0	0	0	0	0	0	1	4912	875	31	3		3	ECE2	3	183996310	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	628116	183996310	14026120	134	22748											
PSMD2	5708	broad.mit.edu	37	chr3	184022098	184022098	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggcttttgcaggctaggCttggcttatgctggctcaaa	7	13	12	9	0	1	0	1	0	0	0	1	0	1	0	0	5	2	7	0	5	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:184022098C>T	uc003fnn.1	+	12	1491	c.1458C>T	c.(1456-1458)GGC>GGT	p.G486G	PSMD2_uc011brj.1_Silent_p.G327G|PSMD2_uc011brk.1_Silent_p.G356G	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	486	PC 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	GCAGGCTAGGCTTGGCTTATG	0.458													51	137					0	0	0	0	T	184022098	T	T	184022098	2	4	128	1	0	0	0	0	0	0	0	1	12760	784	28	4		4	PSMD2	3	184022098	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	25788	184022098	14000332	135	22749											
EIF4G1	1981	broad.mit.edu	37	chr3	184046444	184046444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaaatcttggaattggctGaggacatggaaattgacatc	14	11	11	5	0	1	3	0	3	1	0	2	6	1	6	0	4	0	1	0	4	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:184046444G>A	uc003fnp.2	+	27	4177	c.3979G>A	c.(3979-3981)GAG>AAG	p.E1327K	EIF4G1_uc003fnt.2_Missense_Mutation_p.E1038K|EIF4G1_uc003fnq.2_Missense_Mutation_p.E1240K|EIF4G1_uc003fnr.2_Missense_Mutation_p.E1163K|EIF4G1_uc010hxx.2_Missense_Mutation_p.E1334K|EIF4G1_uc003fns.2_Missense_Mutation_p.E1287K|EIF4G1_uc010hxy.2_Missense_Mutation_p.E1334K|EIF4G1_uc003fnv.3_Missense_Mutation_p.E1328K|EIF4G1_uc003fnu.3_Missense_Mutation_p.E1327K|EIF4G1_uc003fnw.2_Missense_Mutation_p.E1334K|EIF4G1_uc003fnx.2_Missense_Mutation_p.E1132K|EIF4G1_uc003fny.3_Missense_Mutation_p.E1131K|EIF4G1_uc003foa.2_5'UTR	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1327	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAATTGGCTGAGGACATGGA	0.537													31	187					0	0	0	0	A	184046444	A	A	184046444	3	1	128	1	0	0	0	0	1	0	0	0	5060	1291	45	2	4077	2	EIF4G1	3	184046444	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	24346	184046444	13975986	136	22750											
ETV5	2119	broad.mit.edu	37	chr3	185823423	185823423	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctttactaccttcagaatCgtgagccagatctgtgtcca	10	12	8	11	1	2	3	1	1	1	2	4	3	3	3	3	0	4	1	3	0	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:185823423C>T	uc003fpz.2	-	3	371	c.124G>A	c.(124-126)GAT>AAT	p.D42N	ETV5_uc003fpy.2_Missense_Mutation_p.D84N	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	42					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			CCTTCAGAATCGTGAGCCAGA	0.478			T	TMPRSS2|SCL45A3	Prostate 								9	106					0	0	0	0	T	185823423	T	T	185823423	3	4	128	1	0	0	0	0	1	0	0	0	5306	884	31	1	1452	1	ETV5	3	185823423	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1776979	185823423	12199007	137	22751											
KNG1	3827	broad.mit.edu	37	chr3	186450325	186450325	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaccacctaccaagatttgCgtgggctgccccagagatat	11	8	9	13	1	0	2	0	0	0	2	0	3	0	2	5	1	4	1	5	1	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:186450325C>T	uc011bsa.1	+	7	1004	c.792C>T	c.(790-792)TGC>TGT	p.C264C	KNG1_uc003fqr.2_Silent_p.C264C	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	264	Cystatin 3.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CCAAGATTTGCGTGGGCTGCC	0.488													21	127					0	0	0	0	T	186450325	T	T	186450325	2	4	128	1	0	0	0	0	0	0	0	1	8466	776	27	1		1	KNG1	3	186450325	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	626902	186450325	11572105	138	22752											
ATP13A4	84239	broad.mit.edu	37	chr3	193185238	193185238	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggcacagagctatccatCttgggtaacggagttttggt	9	11	13	8	1	1	1	0	0	1	1	2	2	2	2	1	4	2	4	1	4	2	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:193185238C>T	uc003ftd.2	-	10	1089	c.981G>A	c.(979-981)AAG>AAA	p.K327K	ATP13A4_uc003fte.1_Silent_p.K327K|ATP13A4_uc011bsr.1_5'UTR|ATP13A4_uc010hzi.2_RNA|ATP13A4_uc003ftf.3_Silent_p.K33K	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	327	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AGCTATCCATCTTGGGTAACG	0.478													15	137					0	0	0	0	T	193185238	T	T	193185238	2	4	128	1	0	0	0	0	0	0	0	1	1128	912	32	2		2	ATP13A4	3	193185238	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	6734913	193185238	4837192	139	22753											
APOD	347	broad.mit.edu	37	chr3	195306307	195306307	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgaagaggccagccagtgcgGaaagcagcagcagcagcatc	13	2	14	12	2	0	1	0	0	0	1	1	3	0	2	2	2	7	5	2	2	2	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:195306307G>A	uc003fur.2	-	2	388	c.26C>T	c.(25-27)TCC>TTC	p.S9F	APOD_uc011bsx.1_Missense_Mutation_p.S9F	NM_001647	NP_001638	P05090	APOD_HUMAN	apolipoprotein D precursor	9					lipid metabolic process	extracellular space	lipid binding|lipid transporter activity|protein binding			ovary(2)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		AGCCAGTGCGGAAAGCAGCAG	0.577													6	55					0	0	0	0	A	195306307	A	A	195306307	3	1	128	1	0	0	0	0	1	0	0	0	801	1174	41	2	559	2	APOD	3	195306307	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2121069	195306307	2716123	140	22754											
MUC4	4585	broad.mit.edu	37	chr3	195511937	195511937	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaagagaggtggcgtgacCtgtggatgctgaggaagtgt	10	8	19	4	1	0	3	0	2	0	1	0	7	0	6	1	5	1	1	1	5	2	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:195511937C>T	uc011bto.1	-	2	6974	c.6514G>A	c.(6514-6516)GGT>AGT	p.G2172S	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTGGCGTGACCTGTGGATGCT	0.577													2	0					0	0	0	0	T	195511937	T	T	195511937	3	4	128	1	0	0	0	0	1	0	0	0	10031	681	24	4		4	MUC4	3	195511937	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	205630	195511937	2510493	141	22755											
WDR53	348793	broad.mit.edu	37	chr3	196288262	196288262	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccgtgagatctccgccctCtgctccagaagccagcagcc	8	6	10	17	2	2	2	0	1	2	2	4	3	3	2	6	0	5	2	6	0	1	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:196288262C>G	uc003fwt.2	-	3	556	c.85G>C	c.(85-87)GAG>CAG	p.E29Q		NM_182627	NP_872433	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	29	WD 1.									breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		TCTCCGCCCTCTGCTCCAGAA	0.542													7	38					0	0	0	0	G	196288262	G	G	196288262	3	3	128	1	0	0	0	0	1	0	0	0	17373	922	32	2	999	2	WDR53	3	196288262	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	776325	196288262	1734168	142	22756											
WDR53	348793	broad.mit.edu	37	chr3	196288299	196288299	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcccttctttacttgcattCaggcagaggacaggagaaga	12	9	11	9	0	2	3	1	0	1	3	2	5	2	4	1	3	3	2	1	3	2	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:196288299C>G	uc003fwt.2	-	3	519	c.48G>C	c.(46-48)CTG>CTC	p.L16L		NM_182627	NP_872433	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	16	WD 1.									breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		TACTTGCATTCAGGCAGAGGA	0.532													9	45					0	0	0	0	G	196288299	G	G	196288299	2	3	128	1	0	0	0	0	0	0	0	1	17373	813	29	2		2	WDR53	3	196288299	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	37	196288299	1734131	143	22757											
C3orf34	84984	broad.mit.edu	37	chr3	196434703	196434703	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaaaactgaatagcttctCtagctgcctcagggatactt	13	12	7	9	0	2	1	1	1	1	0	3	2	2	2	1	1	5	2	1	1	7	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:196434703C>T	uc011btw.1	-	3	605	c.223G>A	c.(223-225)GAG>AAG	p.E75K		NM_032898	NP_116287	Q96LK0	CEP19_HUMAN	hypothetical protein LOC84984	71						centriole|spindle pole					0	all_cancers(143;1.48e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00301)		AATAGCTTCTCTAGCTGCCTC	0.438													32	155					0	0	0	0	T	196434703	T	T	196434703	3	4	128	1	0	0	0	0	1	0	0	0	2234	922	32	2	284	2	C3orf34	3	196434703	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	146404	196434703	1587727	144	22758											
PAK2	5062	broad.mit.edu	37	chr3	196534686	196534686	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtaattgaccctgttcctGcaccagttggtgattcacat	8	14	8	11	0	1	2	1	2	0	0	2	2	2	2	3	1	1	4	3	1	1	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:196534686G>A	uc003fwy.3	+	7	932	c.610G>A	c.(610-612)GCA>ACA	p.A204T		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	204					axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		CCCTGTTCCTGCACCAGTTGG	0.393													8	90					0	0	0	0	A	196534686	A	A	196534686	3	1	128	1	0	0	0	0	1	0	0	0	11455	1319	46	4	632	4	PAK2	3	196534686	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	99983	196534686	1487744	145	22759											
SENP5	205564	broad.mit.edu	37	chr3	196626904	196626904	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatggacgacctggcgactCtggatggtcagaactggctg	9	9	14	9	2	2	1	1	0	1	1	2	5	2	3	1	5	1	1	1	5	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:196626904C>G	uc003fwz.3	+	4	1978	c.1729C>G	c.(1729-1731)CTG>GTG	p.L577V	SENP5_uc011bty.1_Missense_Mutation_p.L577V	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	577	Protease.				cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		CCTGGCGACTCTGGATGGTCA	0.383													13	70					0	0	0	0	G	196626904	G	G	196626904	3	3	128	1	0	0	0	0	1	0	0	0	14114	912	32	2	1739	2	SENP5	3	196626904	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	92218	196626904	1395526	146	22760											
FGFR3	2261	broad.mit.edu	37	chr4	1803568	1803568	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atctgcccccacagagcgctCcccgcaccggcccatcctgc	6	5	8	22	3	1	1	0	0	1	1	3	1	3	1	7	1	3	2	7	1	0	0	rs121913483		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				4	16					0	0	0	0	G	1803568	G	G	1803568	3	3	128	1	0	0	0	0	1	0	0	0	5899	855	30	2	768	2	FGFR3	4	1803568	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08		1803568	189350708	147	22761											
TNIP2	79155	broad.mit.edu	37	chr4	2746559	2746559	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccgggagatctccttcctCatcagctcgggctcgtgggg	5	9	14	13	3	3	1	2	0	1	1	7	2	4	1	3	4	2	2	3	4	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:2746559C>T	uc003gfg.2	-	4	858	c.771G>A	c.(769-771)ATG>ATA	p.M257I	TNIP2_uc003gff.2_Missense_Mutation_p.M150I|TNIP2_uc003gfh.2_Intron	NM_024309	NP_077285	Q8NFZ5	TNIP2_HUMAN	A20-binding inhibitor of NF-kappaB activation 2	257	Potential.					cytosol	protein binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCTCCTTCCTCATCAGCTCGG	0.612													19	72					0	0	0	0	T	2746559	T	T	2746559	3	4	128	1	0	0	0	0	1	0	0	0	16381	826	29	2	530	2	TNIP2	4	2746559	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	942991	2746559	188407717	148	22762											
LAP3	51056	broad.mit.edu	37	chr4	17583385	17583385	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatttcctcttgttttagatCtggaccacctctgaaggcag	8	15	8	10	0	3	2	0	1	3	1	4	3	4	3	3	2	0	2	3	2	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:17583385C>T	uc003gph.1	+	3	383	c.221C>T	c.(220-222)TCT>TTT	p.S74F	LAP3_uc010ieg.2_Missense_Mutation_p.S74F	NM_015907	NP_056991	P28838	AMPL_HUMAN	leucine aminopeptidase 3	74					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding				0						TGTTTTAGATCTGGACCACCT	0.358													12	74					0	0	0	0	T	17583385	T	T	17583385	3	4	128	1	0	0	0	0	1	0	0	0	8663	913	32	2	231	2	LAP3	4	17583385	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	14836826	17583385	173570891	149	22763											
GABRB1	2560	broad.mit.edu	37	chr4	47427752	47427752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccggaatgagacgagtggctCggaagtgctcacgagcgtga	10	6	16	9	5	1	2	1	2	0	1	2	7	1	4	1	3	2	2	1	3	2	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:47427752C>T	uc003gxh.2	+	9	1516	c.1142C>T	c.(1141-1143)TCG>TTG	p.S381L	GABRB1_uc011bze.1_Missense_Mutation_p.S311L	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	381	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACGAGTGGCTCGGAAGTGCTC	0.597													10	59					0	0	0	0	T	47427752	T	T	47427752	3	4	128	1	0	0	0	0	1	0	0	0	6200	893	31	1	1176	1	GABRB1	4	47427752	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	29844367	47427752	143726524	150	22764											
CWH43	80157	broad.mit.edu	37	chr4	49034613	49034613	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcaagatacccaattgtGaaatctgagcatcaccttct	12	13	6	10	0	4	3	2	2	2	1	4	3	4	3	2	0	2	1	2	0	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:49034613G>T	uc003gyv.2	+	12	1721	c.1539G>T	c.(1537-1539)GTG>GTT	p.V513V	CWH43_uc011bzl.1_Silent_p.V486V	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	513					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						ACCCAATTGTGAAATCTGAGC	0.468													38	204					2.40579e-17	2.58995e-17	1	0	T	49034613	T	T	49034613	2	4	128	1	0	0	0	0	0	0	0	1	4090	1277	45	2		2	CWH43	4	49034613	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1606861	49034613	142119663	151	22765											
AASDH	132949	broad.mit.edu	37	chr4	57244556	57244556	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtatttttccagtgaagtctGaagagcactaggtcattatg	11	14	10	6	0	2	3	1	2	1	1	3	3	3	3	1	1	1	2	1	1	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:57244556G>A	uc003hbn.2	-	4	579	c.426C>T	c.(424-426)TTC>TTT	p.F142F	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_5'UTR|AASDH_uc003hbo.2_Silent_p.F42F|AASDH_uc011cab.1_Intron|AASDH_uc010ihc.2_Silent_p.F142F|AASDH_uc003hbp.2_Silent_p.F142F	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	142					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				AGTGAAGTCTGAAGAGCACTA	0.313													6	49					0	0	0	0	A	57244556	A	A	57244556	2	1	128	1	0	0	0	0	0	0	0	1	22	1281	45	2		2	AASDH	4	57244556	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	8209943	57244556	133909720	152	22766											
YTHDC1	91746	broad.mit.edu	37	chr4	69203024	69203024	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcttcttccactccttcctCctcattctcagtgttgttcc	4	18	3	16	0	4	0	2	0	3	0	10	0	9	0	5	0	0	2	5	0	0	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:69203024C>T	uc003hdx.2	-	4	957	c.604G>A	c.(604-606)GAG>AAG	p.E202K	YTHDC1_uc003hdy.2_Missense_Mutation_p.E202K	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	202	Glu-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						actccttcctcctcATTCTCA	0.219													5	35					0	0	0	0	T	69203024	T	T	69203024	3	4	128	1	0	0	0	0	1	0	0	0	17564	864	30	2	1635	2	YTHDC1	4	69203024	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	11958468	69203024	121951252	153	22767											
FRAS1	80144	broad.mit.edu	37	chr4	79328882	79328882	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaagggcagcacctgcctGatgggaggacagctaccccc	10	5	13	13	0	0	2	0	2	0	0	0	4	0	4	4	3	4	3	4	3	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:79328882G>C	uc003hlb.2	+	31	4635	c.4195G>C	c.(4195-4197)GAT>CAT	p.D1399H	FRAS1_uc003hkw.2_Missense_Mutation_p.D1399H	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1398	CSPG 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GCACCTGCCTGATGGGAGGAC	0.587													8	56					0	0	0	0	C	79328882	C	C	79328882	3	2	128	1	0	0	0	0	1	0	0	0	6076	1290	45	2	4317	2	FRAS1	4	79328882	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	10125858	79328882	111825394	154	22768											
FRAS1	80144	broad.mit.edu	37	chr4	79461904	79461904	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atatgaagtccctgaatctgGagatgcaagagttggcggta	12	10	13	6	1	1	4	0	2	1	2	2	5	2	4	1	3	1	3	1	3	5	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:79461904G>A	uc003hlb.2	+	74	12105	c.11665G>A	c.(11665-11667)GAG>AAG	p.E3889K		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3884	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CCTGAATCTGGAGATGCAAGA	0.517													4	22					0	0	0	0	A	79461904	A	A	79461904	3	1	128	1	0	0	0	0	1	0	0	0	6076	1175	41	2	12034	2	FRAS1	4	79461904	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	133022	79461904	111692372	155	22769											
ABCG2	9429	broad.mit.edu	37	chr4	89052248	89052248	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttatccagacctaactcttGaatgaccctgttaatccgtt	10	15	5	11	1	1	3	0	2	1	1	3	3	3	3	4	0	1	2	4	0	4	6	rs1061017		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:89052248G>C	uc003hrg.2	-	5	989	c.496C>G	c.(496-498)CAA>GAA	p.Q166E	ABCG2_uc003hrh.2_Missense_Mutation_p.Q166E|ABCG2_uc003hrf.2_Missense_Mutation_p.Q36E	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	166	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	CCTAACTCTTGAATGACCCTG	0.418													27	161					0	0	0	0	C	89052248	C	C	89052248	3	2	128	1	0	0	0	0	1	0	0	0	69	1299	45	2	1519	2	ABCG2	4	89052248	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	9590344	89052248	102102028	156	22770											
LRIT3	345193	broad.mit.edu	37	chr4	110791623	110791623	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcaccttttctactgaaaGagttgaaggagatgattctc	12	13	8	8	0	3	5	1	3	2	2	4	6	3	5	1	1	1	1	1	1	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:110791623G>A	uc003hzx.3	+	3	1776	c.1583G>A	c.(1582-1584)AGA>AAA	p.R528K	LRIT3_uc003hzw.3_Missense_Mutation_p.R390K	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	528	Fibronectin type-III.					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		TCTACTGAAAGAGTTGAAGGA	0.453													17	65					0	0	0	0	A	110791623	A	A	110791623	3	1	128	1	0	0	0	0	1	0	0	0	8999	942	33	2	1593	2	LRIT3	4	110791623	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	21739375	110791623	80362653	157	22771											
KIAA1109	84162	broad.mit.edu	37	chr4	123161431	123161431	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctctaaatcctcattgcatCgtccccttgatctggataca	9	13	5	14	1	3	1	1	1	2	0	6	2	5	2	4	1	2	1	4	1	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:123161431C>T	uc003ieh.2	+	27	4639	c.4594C>T	c.(4594-4596)CGT>TGT	p.R1532C	KIAA1109_uc003iei.1_Missense_Mutation_p.R1285C|KIAA1109_uc010ins.1_Missense_Mutation_p.R875C|KIAA1109_uc003iek.2_Missense_Mutation_p.R151C	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1532					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CTCATTGCATCGTCCCCTTGA	0.383													15	77					0	0	0	0	T	123161431	T	T	123161431	3	4	128	1	0	0	0	0	1	0	0	0	8247	884	31	1	4700	1	KIAA1109	4	123161431	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	12369808	123161431	67992845	158	22772											
RNF150	57484	broad.mit.edu	37	chr4	142053860	142053860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggtgtaccattcctccttctCggccacggtaaagtccaggc	7	10	10	14	2	1	0	0	0	1	0	5	0	4	0	5	4	1	2	5	4	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:142053860C>G	uc003iio.1	-	1	757	c.103G>C	c.(103-105)GAG>CAG	p.E35Q	RNF150_uc010iok.1_Missense_Mutation_p.E35Q|RNF150_uc003iip.1_Missense_Mutation_p.E35Q	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	35	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					TCCTCCTTCTCGGCCACGGTA	0.418													8	44					0	0	0	0	G	142053860	G	G	142053860	3	3	128	1	0	0	0	0	1	0	0	0	13516	893	31	3	1241	3	RNF150	4	142053860	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	18892429	142053860	49100416	159	22773											
NR3C2	4306	broad.mit.edu	37	chr4	149357542	149357542	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgatctcaagggcgtgttCacacaacttagagtggaagg	13	9	12	7	1	2	2	2	1	1	1	3	3	2	3	0	3	1	1	0	3	5	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:149357542C>T	uc003ilj.3	-	2	805	c.471G>A	c.(469-471)GTG>GTA	p.V157V	NR3C2_uc003ilk.3_Silent_p.V157V|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	157	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	AGGGCGTGTTCACACAACTTA	0.448													16	132					0	0	0	0	T	149357542	T	T	149357542	2	4	128	1	0	0	0	0	0	0	0	1	10685	813	29	2		2	NR3C2	4	149357542	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	7303682	149357542	41796734	160	22774											
KIAA0922	23240	broad.mit.edu	37	chr4	154553947	154553947	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taaactgcaccctggagaacGgcgtgccttgtgtgattcag	9	10	12	10	2	1	2	1	1	0	1	1	3	1	2	2	2	4	1	2	2	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:154553947G>A	uc003inm.3	+	32	4334	c.4282G>A	c.(4282-4284)GGC>AGC	p.G1428S	KIAA0922_uc010ipp.2_Missense_Mutation_p.G1429S|KIAA0922_uc010ipq.2_Missense_Mutation_p.G1197S	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1428	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CCTGGAGAACGGCGTGCCTTG	0.532													11	51					0	0	0	0	A	154553947	A	A	154553947	3	1	128	1	0	0	0	0	1	0	0	0	8240	1116	39	1	4411	1	KIAA0922	4	154553947	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	5196405	154553947	36600329	161	22775											
FNIP2	57600	broad.mit.edu	37	chr4	159790180	159790180	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctgacaagggttttgcagagGacagaggcagcagaaacgac	14	5	14	8	1	0	4	0	1	0	3	0	6	0	5	0	3	3	4	0	3	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:159790180G>C	uc003iqe.3	+	13	2575	c.2392G>C	c.(2392-2394)GAC>CAC	p.D798H		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	798	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		TTTTGCAGAGGACAGAGGCAG	0.562													13	143					0	0	0	0	C	159790180	C	C	159790180	3	2	128	1	0	0	0	0	1	0	0	0	6008	1174	41	2	2442	2	FNIP2	4	159790180	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	5236233	159790180	31364096	162	22776											
CDH10	1008	broad.mit.edu	37	chr5	24537725	24537725	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taataaaaagagtaccagctCcatctccagataagatatat	18	10	5	8	0	1	3	0	0	1	3	3	3	2	3	3	0	2	2	3	0	8	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:24537725C>A	uc003jgr.1	-	3	622	c.290G>T	c.(289-291)GGA>GTA	p.G97V	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	97	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AGTACCAGCTCCATCTCCAGA	0.363										HNSCC(23;0.051)			9	58					7.48243e-07	7.85061e-07	1	0	A	24537725	A	A	24537725	3	1	128	1	0	0	0	0	1	0	0	0	3111	855	30	2	2116	2	CDH10	5	24537725	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08		24537725	156377535	163	22777											
RXFP3	51289	broad.mit.edu	37	chr5	33938124	33938124	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccactaccaagccggagcacGaggatcaggggctgcaggcc	10	3	14	14	2	1	0	1	0	0	0	1	3	1	2	4	5	4	3	4	5	2	1	rs138975968		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:33938124G>A	uc003jic.1	+	1	1636	c.1279G>A	c.(1279-1281)GAG>AAG	p.E427K		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	427	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GCCGGAGCACGAGGATCAGGG	0.567													6	23					0	0	0	0	A	33938124	A	A	33938124	3	1	128	1	0	0	0	0	1	0	0	0	13826	1059	37	1	1281	1	RXFP3	5	33938124	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	9400399	33938124	146977136	164	22778											
LMBRD2	92255	broad.mit.edu	37	chr5	36122457	36122457	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggtgtgaacaaactgatGagtagcactagtttcatttt	14	13	9	5	0	1	3	1	3	0	0	1	3	1	3	0	1	3	3	0	1	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:36122457G>A	uc003jkb.1	-	9	1460	c.1045C>T	c.(1045-1047)CAT>TAT	p.H349Y		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	349	Cytoplasmic (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACAAACTGATGAGTAGCACTA	0.333													10	41					0	0	0	0	A	36122457	A	A	36122457	3	1	128	1	0	0	0	0	1	0	0	0	8885	1290	45	2	1082	2	LMBRD2	5	36122457	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2184333	36122457	144792803	165	22779											
GDNF	2668	broad.mit.edu	37	chr5	37815932	37815932	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattttgtcgtacgttgtctCagctgcatcgcaagagccgc	7	13	10	11	4	1	1	1	0	1	1	4	1	1	1	1	0	4	5	1	0	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:37815932C>G	uc011cpi.1	-	3	657	c.457G>C	c.(457-459)GAG>CAG	p.E153Q	GDNF_uc011cpc.1_Missense_Mutation_p.E75Q|GDNF_uc011cpd.1_Missense_Mutation_p.E101Q|GDNF_uc011cpe.1_Missense_Mutation_p.E127Q|GDNF_uc011cpf.1_Missense_Mutation_p.E127Q|GDNF_uc011cpg.1_Missense_Mutation_p.E170Q|GDNF_uc011cph.1_Missense_Mutation_p.E144Q	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	153					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					TACGTTGTCTCAGCTGCATCG	0.443													10	86					0	0	0	0	G	37815932	G	G	37815932	3	3	128	1	0	0	0	0	1	0	0	0	6359	835	29	2	181	2	GDNF	5	37815932	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1693475	37815932	143099328	166	22780											
OSMR	9180	broad.mit.edu	37	chr5	38883988	38883988	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaaagataagctggtggaaGaaggcaccaatgttaccatt	15	9	10	7	0	0	2	0	0	0	2	0	3	0	3	2	3	2	3	2	3	7	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:38883988G>A	uc003jln.1	+	5	845	c.478G>A	c.(478-480)GAA>AAA	p.E160K	OSMR_uc003jlm.1_Missense_Mutation_p.E160K	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	160	Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					GCTGGTGGAAGAAGGCACCAA	0.363													8	90					0	0	0	0	A	38883988	A	A	38883988	3	1	128	1	0	0	0	0	1	0	0	0	11346	943	33	2	492	2	OSMR	5	38883988	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1068056	38883988	142031272	167	22781											
PARP8	79668	broad.mit.edu	37	chr5	50091252	50091252	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcatcttctcagcttgctGtgcgtaaatattttcatctt	7	19	5	10	1	5	0	3	0	3	0	6	0	5	0	0	0	3	3	0	0	3	8			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:50091252G>A	uc003jon.3	+	13	1610	c.1428_splice	c.e13+1	p.A476_splice	PARP8_uc011cpz.1_Splice_Site_p.A368_splice|PARP8_uc003joo.2_Splice_Site_p.A476_splice|PARP8_uc003jop.2_Splice_Site_p.A476_splice	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				TCAGCTTGCTGTGCGTAAATA	0.393													10	53					0	0	0	0	A	50091252	A	A	50091252	5	1	128	1	0	0	0	0	0	0	1	0	11519	1391	48	4	1475	4	PARP8	5	50091252	Splice_Site	SNP	G	TCGA-CR-6481-01A-11D-1870-08	11207264	50091252	130824008	168	22782											
MAST4	375449	broad.mit.edu	37	chr5	66458527	66458527	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgaacagatccctgtcatCgggtgagagcctcccaggtt	8	10	11	12	1	1	3	1	2	0	2	4	4	3	3	3	2	2	1	3	2	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:66458527C>T	uc003jut.1	+	27	3379	c.3311C>T	c.(3310-3312)TCG>TTG	p.S1104L	MAST4_uc003juw.2_Missense_Mutation_p.S1032L	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1296	Ser-rich.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TCCCTGTCATCGGGTGAGAGC	0.542													11	86					0	0	0	0	T	66458527	T	T	66458527	3	4	128	1	0	0	0	0	1	0	0	0	9380	893	31	1	4118	1	MAST4	5	66458527	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	16367275	66458527	114456733	169	22783											
MAST4	375449	broad.mit.edu	37	chr5	66460113	66460113	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggacaaagaggacaacctCtgccctgtgctgaagcccaa	13	5	11	12	0	1	2	0	1	1	1	1	5	1	4	3	2	4	1	3	2	4	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:66460113C>T	uc003jut.1	+	28	4607	c.4539C>T	c.(4537-4539)CTC>CTT	p.L1513L	MAST4_uc003juw.2_Silent_p.L1441L|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1705						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGGACAACCTCTGCCCTGTGC	0.577													7	24					0	0	0	0	T	66460113	T	T	66460113	2	4	128	1	0	0	0	0	0	0	0	1	9380	900	32	2		2	MAST4	5	66460113	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1586	66460113	114455147	170	22784											
RAD17	5884	broad.mit.edu	37	chr5	68669684	68669684	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgggttgacccatcatttGatgattttctagagtgtagt	9	16	10	6	0	2	4	1	3	1	1	2	4	2	4	1	1	0	2	1	1	2	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:68669684G>C	uc003jwo.2	+	2	132	c.70G>C	c.(70-72)GAT>CAT	p.D24H	RAD17_uc003jwg.2_Missense_Mutation_p.D13H|RAD17_uc003jwh.2_Missense_Mutation_p.D13H|RAD17_uc003jwi.2_Missense_Mutation_p.D13H|RAD17_uc003jwj.2_Missense_Mutation_p.D13H|RAD17_uc003jwk.2_Missense_Mutation_p.D13H|RAD17_uc003jwl.2_Missense_Mutation_p.D13H|RAD17_uc003jwm.2_5'UTR|RAD17_uc003jwn.2_Intron	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	24					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		CCCATCATTTGATGATTTTCT	0.358								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					13	73					0	0	0	0	C	68669684	C	C	68669684	3	2	128	1	0	0	0	0	1	0	0	0	13044	1290	45	2	89	2	RAD17	5	68669684	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2209571	68669684	112245576	171	22785											
RAD17	5884	broad.mit.edu	37	chr5	68669849	68669849	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagaacagatttatggtttaGaaaattcaaaagaatatctg	18	13	7	3	0	2	4	1	0	1	4	2	4	2	4	0	1	1	1	0	1	10	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:68669849G>C	uc003jwo.2	+	2	297	c.235G>C	c.(235-237)GAA>CAA	p.E79Q	RAD17_uc003jwg.2_Missense_Mutation_p.E68Q|RAD17_uc003jwh.2_Missense_Mutation_p.E68Q|RAD17_uc003jwi.2_Missense_Mutation_p.E68Q|RAD17_uc003jwj.2_Missense_Mutation_p.E68Q|RAD17_uc003jwk.2_Missense_Mutation_p.E68Q|RAD17_uc003jwl.2_Missense_Mutation_p.E68Q|RAD17_uc003jwm.2_5'UTR|RAD17_uc003jwn.2_Intron	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	79					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		TTATGGTTTAGAAAATTCAAA	0.333								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					8	77					0	0	0	0	C	68669849	C	C	68669849	3	2	128	1	0	0	0	0	1	0	0	0	13044	943	33	2	254	2	RAD17	5	68669849	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	165	68669849	112245411	172	22786											
GPR98	84059	broad.mit.edu	37	chr5	90041440	90041440	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatttgaacctggtgagaGagaagctacaatagcagtaa	16	9	11	5	0	0	3	0	2	0	2	0	6	0	3	1	1	4	3	1	1	7	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:90041440G>C	uc003kju.2	+	52	10898	c.10802G>C	c.(10801-10803)AGA>ACA	p.R3601T	GPR98_uc003kjt.2_Missense_Mutation_p.R1307T|GPR98_uc003kjv.2_Missense_Mutation_p.R1201T	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3601	Calx-beta 23.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCTGGTGAGAGAGAAGCTACA	0.333													12	56					0	0	0	0	C	90041440	C	C	90041440	3	2	128	1	0	0	0	0	1	0	0	0	6760	942	33	2	11008	2	GPR98	5	90041440	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	21371591	90041440	90873820	173	22787											
TTC37	9652	broad.mit.edu	37	chr5	94849302	94849302	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttagttctgtagtgtgcctGaagagatccatggtgtcata	9	15	11	6	0	2	2	1	1	1	1	3	3	3	2	2	1	1	2	2	1	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:94849302G>C	uc003klb.2	-	27	3021	c.2751C>G	c.(2749-2751)TTC>TTG	p.F917L		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	917							binding			ovary(3)|pancreas(1)	4						TAGTGTGCCTGAAGAGATCCA	0.338													11	116					0	0	0	0	C	94849302	C	C	94849302	3	2	128	1	0	0	0	0	1	0	0	0	16773	1281	45	2	2011	2	TTC37	5	94849302	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4807862	94849302	86065958	174	22788											
FBN2	2201	broad.mit.edu	37	chr5	127653955	127653955	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttataggatctgcacactCatcaatatctaggagaagca	14	11	8	8	0	4	1	2	0	2	1	4	3	4	2	0	2	2	3	0	2	6	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:127653955C>G	uc003kuu.2	-	36	5042	c.4603G>C	c.(4603-4605)GAG>CAG	p.E1535Q		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1535	EGF-like 26; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCTGCACACTCATCAATATCT	0.423													23	131					0	0	0	0	G	127653955	G	G	127653955	3	3	128	1	0	0	0	0	1	0	0	0	5735	835	29	2	4255	2	FBN2	5	127653955	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	32804653	127653955	53261305	175	22789											
RAPGEF6	51735	broad.mit.edu	37	chr5	130857157	130857157	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agactgactagaagacacatGagtcacctgtggatgagggt	13	8	13	7	0	1	6	1	3	0	3	1	7	1	7	1	2	0	0	1	2	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:130857157G>A	uc003kvn.1	-	7	759	c.553C>T	c.(553-555)CAT>TAT	p.H185Y	RAPGEF6_uc003kvp.1_Missense_Mutation_p.H235Y|RAPGEF6_uc003kvo.1_Missense_Mutation_p.H185Y|RAPGEF6_uc010jdi.1_Missense_Mutation_p.H185Y|RAPGEF6_uc010jdj.1_Missense_Mutation_p.H185Y|RAPGEF6_uc003kvr.2_Missense_Mutation_p.H185Y|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.H185Y	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	185					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		GAAGACACATGAGTCACCTGT	0.383													8	59					0	0	0	0	A	130857157	A	A	130857157	3	1	128	1	0	0	0	0	1	0	0	0	13113	1290	45	2	4826	2	RAPGEF6	5	130857157	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3203202	130857157	50058103	176	22790											
SLC22A4	6583	broad.mit.edu	37	chr5	131679482	131679482	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggaaaaaaacaagagactCaatggagacagaagaaaatc	22	4	10	5	0	1	4	1	0	0	4	2	7	1	5	0	2	1	0	0	2	8	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:131679482C>T	uc003kwq.2	+	10	1775	c.1610C>T	c.(1609-1611)TCA>TTA	p.S537L	uc003kwr.3_Intron	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	537	Cytoplasmic (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	ACAAGAGACTCAATGGAGACA	0.343													6	26					0	0	0	0	T	131679482	T	T	131679482	3	4	128	1	0	0	0	0	1	0	0	0	14520	838	29	2	1648	2	SLC22A4	5	131679482	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	822325	131679482	49235778	177	22791											
PKD2L2	27039	broad.mit.edu	37	chr5	137271509	137271509	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcaaaacgcagagcagatGaaaaaatggaaagagaggct	20	5	11	5	1	1	4	1	1	0	3	1	6	1	5	0	2	2	3	0	2	6	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:137271509G>A	uc003lby.2	+	13	1751	c.1695G>A	c.(1693-1695)ATG>ATA	p.M565I	PKD2L2_uc003lbw.1_Missense_Mutation_p.M565I|PKD2L2_uc003lbx.2_Missense_Mutation_p.M464I|PKD2L2_uc011cyi.1_Missense_Mutation_p.M173I	NM_014386	NP_055201	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	565	Cytoplasmic (Potential).|Potential.					integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAGAGCAGATGAAAAAATGGA	0.398													6	44					0	0	0	0	A	137271509	A	A	137271509	3	1	128	1	0	0	0	0	1	0	0	0	12023	1290	45	2	1745	2	PKD2L2	5	137271509	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	5592027	137271509	43643751	178	22792											
ETF1	2107	broad.mit.edu	37	chr5	137847221	137847221	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggacttcagtagataactCaatagcttggttgaatccat	13	12	9	7	0	2	2	2	1	0	1	3	4	3	3	1	2	2	3	1	2	5	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:137847221C>G	uc003ldc.3	-	7	970	c.805G>C	c.(805-807)GAG>CAG	p.E269Q	ETF1_uc011cyv.1_Missense_Mutation_p.E255Q|ETF1_uc010jex.2_RNA|ETF1_uc003ldd.3_Missense_Mutation_p.E236Q|ETF1_uc010jey.1_Missense_Mutation_p.E75Q	NM_004730	NP_004721	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	269					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTAGATAACTCAATAGCTTGG	0.299													8	41					0	0	0	0	G	137847221	G	G	137847221	3	3	128	1	0	0	0	0	1	0	0	0	5292	835	29	2	528	2	ETF1	5	137847221	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	575712	137847221	43068039	179	22793											
SLC4A9	83697	broad.mit.edu	37	chr5	139745140	139745140	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggataaggacaaggccaaaaGacagagacgacattgtaagc	18	4	12	7	1	0	2	0	0	0	2	0	6	0	4	1	3	1	1	1	3	5	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:139745140G>C	uc003lfm.2	+	12	1794	c.1759G>C	c.(1759-1761)GAC>CAC	p.D587H	SLC4A9_uc003lfj.2_Missense_Mutation_p.D563H|SLC4A9_uc011czg.1_Missense_Mutation_p.D563H|SLC4A9_uc003lfl.2_Missense_Mutation_p.D563H|SLC4A9_uc003lfk.2_Missense_Mutation_p.D552H	NM_031467	NP_113655	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate	587	Extracellular (Potential).|Membrane (anion exchange).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGCCAAAAGACAGAGACGA	0.507													7	20					0	0	0	0	C	139745140	C	C	139745140	3	2	128	1	0	0	0	0	1	0	0	0	14724	942	33	2	1733	2	SLC4A9	5	139745140	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1897919	139745140	41170120	180	22794											
PCDHA1	56147	broad.mit.edu	37	chr5	140167978	140167978	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgtcaacgtgtacctgatCatcgccatctgcgcggtgtc	7	11	11	12	4	3	1	2	1	1	0	5	2	3	1	2	1	3	1	2	1	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:140167978C>T	uc003lhb.2	+	1	2103	c.2103C>T	c.(2101-2103)ATC>ATT	p.I701I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Silent_p.I701I	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	701	Helical; (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTACCTGATCATCGCCATCT	0.682													19	78					0	0	0	0	T	140167978	T	T	140167978	2	4	128	1	0	0	0	0	0	0	0	1	11573	816	29	2		2	PCDHA1	5	140167978	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	422838	140167978	40747282	181	22795											
PCDHA6	56142	broad.mit.edu	37	chr5	140208515	140208515	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatggggcaatttcatattCttttaatagccttgttgcag	10	16	9	6	0	2	0	1	0	1	0	2	1	2	0	1	2	2	3	1	2	5	8			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:140208515C>G	uc003lho.2	+	1	866	c.839C>G	c.(838-840)TCT>TGT	p.S280C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.S280C|PCDHA6_uc011dab.1_Missense_Mutation_p.S280C	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	280	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTCATATTCTTTTAATAGC	0.388													20	92					0	0	0	0	G	140208515	G	G	140208515	3	3	128	1	0	0	0	0	1	0	0	0	11582	913	32	2	841	2	PCDHA6	5	140208515	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	40537	140208515	40706745	182	22796											
PCDHGA6	56109	broad.mit.edu	37	chr5	140754586	140754586	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aatctagactatgaggactcGagtttttatgagctgggtgt	10	14	12	5	1	1	3	0	2	1	1	2	5	1	4	0	2	1	2	0	2	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:140754586G>C	uc003ljy.1	+	1	936	c.936G>C	c.(934-936)TCG>TCC	p.S312S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.S312S	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	312	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAGGACTCGAGTTTTTATG	0.393													32	148					0	0	0	0	C	140754586	C	C	140754586	2	2	128	1	0	0	0	0	0	0	0	1	11612	1045	37	3		3	PCDHGA6	5	140754586	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	546071	140754586	40160674	183	22797											
FAT2	2196	broad.mit.edu	37	chr5	150897219	150897219	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtttcattggtgaatagaaGaatggcctgtggctggagtg	9	13	15	4	0	1	3	1	1	0	2	1	4	1	4	1	4	0	2	1	4	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:150897219G>A	uc003lue.3	-	19	11438	c.11425C>T	c.(11425-11427)CTT>TTT	p.L3809F	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.L502F	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3809	Extracellular (Potential).|Laminin G-like.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGAATAGAAGAATGGCCTGT	0.552													10	65					0	0	0	0	A	150897219	A	A	150897219	3	1	128	1	0	0	0	0	1	0	0	0	5722	942	33	2	1644	2	FAT2	5	150897219	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	10142633	150897219	30018041	184	22798											
KIF4B	285643	broad.mit.edu	37	chr5	154393878	154393878	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaaattttggatcttctatgCccatctcgtgagaaagctca	11	13	8	9	1	4	1	1	1	3	1	5	4	4	2	1	1	2	1	1	1	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:154393878C>A	uc010jih.1	+	1	619	c.459C>A	c.(457-459)TGC>TGA	p.C153*		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	153	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATCTTCTATGCCCATCTCGTG	0.358													22	145					1.9806e-07	2.09468e-07	1	0	A	154393878	A	A	154393878	4	1	128	1	0	0	0	0	0	1	0	0	8343	747	26	4	461	4	KIF4B	5	154393878	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3496659	154393878	26521382	185	22799											
C5orf41	153222	broad.mit.edu	37	chr5	172560701	172560701	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agaagactgcagaagggaatCccactggaggccttgtagga	13	6	14	8	0	0	3	0	0	0	3	1	6	1	6	2	4	1	2	2	4	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:172560701C>T	uc003mch.2	+	9	2177	c.1873C>T	c.(1873-1875)CCC>TCC	p.P625S	C5orf41_uc011dfd.1_Missense_Mutation_p.P625S	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	625							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGAAGGGAATCCCACTGGAGG	0.443													10	40					0	0	0	0	T	172560701	T	T	172560701	3	4	128	1	0	0	0	0	1	0	0	0	2310	855	30	2	1935	2	C5orf41	5	172560701	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	18166823	172560701	8354559	186	22800											
NKX2-5	1482	broad.mit.edu	37	chr5	172660137	172660137	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacgcgcggcttcctccgcCgtcgcgcccggggccgctcc	1	5	14	21	9	0	0	0	0	0	0	4	0	3	0	6	3	0	3	6	3	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:172660137C>G	uc003mcm.1	-	2	586	c.410G>C	c.(409-411)CGG>CCG	p.R137P	NKX2-5_uc011dfe.1_3'UTR|NKX2-5_uc010jjt.1_3'UTR	NM_004387	NP_004378	P52952	NKX25_HUMAN	NK2 transcription factor related, locus 5	137					adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CTTCCTCCGCCGTCGCGCCCG	0.692													3	11					0	0	0	0	G	172660137	G	G	172660137	3	3	128	1	0	0	0	0	1	0	0	0	10507	652	23	3	568	3	NKX2-5	5	172660137	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	99436	172660137	8255123	187	22801											
NSD1	64324	broad.mit.edu	37	chr5	176673765	176673765	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgtaaaaaagtgaaaaatGatgactcgtcaaaagagatt	20	9	9	3	1	1	4	1	3	0	1	2	5	1	4	0	0	0	1	0	0	7	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:176673765G>A	uc003mfr.3	+	10	4603	c.4465G>A	c.(4465-4467)GAT>AAT	p.D1489N	NSD1_uc003mft.3_Missense_Mutation_p.D1220N|NSD1_uc003mfs.1_Missense_Mutation_p.D1386N|NSD1_uc011dfx.1_Missense_Mutation_p.D1137N	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1489					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGTGAAAAATGATGACTCGTC	0.438			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			13	54					0	0	0	0	A	176673765	A	A	176673765	3	1	128	1	0	0	0	0	1	0	0	0	10723	1290	45	2	4499	2	NSD1	5	176673765	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4013628	176673765	4241495	188	22802											
TBC1D9B	23061	broad.mit.edu	37	chr5	179302008	179302008	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggatcaccttgatgccctCatagaaaaagcagtcgacga	14	7	9	11	2	2	2	2	1	0	1	3	5	2	3	2	1	2	1	2	1	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:179302008C>T	uc003mlh.2	-	12	2117	c.2080G>A	c.(2080-2082)GAG>AAG	p.E694K	TBC1D9B_uc003mli.2_Missense_Mutation_p.E694K|TBC1D9B_uc003mlj.2_Missense_Mutation_p.E694K|TBC1D9B_uc011dgv.1_5'Flank	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	694	Rab-GAP TBC.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTGATGCCCTCATAGAAAAAG	0.622													10	49					0	0	0	0	T	179302008	T	T	179302008	3	4	128	1	0	0	0	0	1	0	0	0	15694	835	29	2	1716	2	TBC1D9B	5	179302008	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2628243	179302008	1613252	189	22803											
DSP	1832	broad.mit.edu	37	chr6	7559514	7559514	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ataaagccatcagtgtccctCgagtccgcagggccagctcc	9	7	10	15	2	1	0	1	0	0	0	5	1	4	0	5	1	2	2	5	1	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:7559514C>G	uc003mxp.1	+	4	757	c.478C>G	c.(478-480)CGA>GGA	p.R160G	DSP_uc003mxq.1_Missense_Mutation_p.R160G	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	160	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CAGTGTCCCTCGAGTCCGCAG	0.507													25	157					0	0	0	0	G	7559514	G	G	7559514	3	3	128	1	0	0	0	0	1	0	0	0	4803	876	31	3	492	3	DSP	6	7559514	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08		7559514	163555553	190	22804											
DSP	1832	broad.mit.edu	37	chr6	7566622	7566622	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcacagatacgcatgagtCaactggaagttaaagaaaaa	19	8	8	6	1	2	3	2	1	0	2	2	4	2	4	0	1	2	2	0	1	7	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:7566622C>T	uc003mxp.1	+	8	1231	c.952C>T	c.(952-954)CAA>TAA	p.Q318*	DSP_uc003mxq.1_Nonsense_Mutation_p.Q318*	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	318	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACGCATGAGTCAACTGGAAGT	0.373													9	63					0	0	0	0	T	7566622	T	T	7566622	4	4	128	1	0	0	0	0	0	1	0	0	4803	827	29	2	982	2	DSP	6	7566622	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	7108	7566622	163548445	191	22805											
DSP	1832	broad.mit.edu	37	chr6	7570715	7570715	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggctctgtggaaccagctCtacatcaacatgaagagcct	11	10	9	11	0	3	2	1	1	2	1	3	3	3	3	2	2	5	2	2	2	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:7570715C>T	uc003mxp.1	+	13	1899	c.1620C>T	c.(1618-1620)CTC>CTT	p.L540L	DSP_uc003mxq.1_Silent_p.L540L	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	540	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GGAACCAGCTCTACATCAACA	0.498													24	114					0	0	0	0	T	7570715	T	T	7570715	2	4	128	1	0	0	0	0	0	0	0	1	4803	900	32	2		2	DSP	6	7570715	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	4093	7570715	163544352	192	22806											
HIST1H2AA	221613	broad.mit.edu	37	chr6	25727627	25727628	+	5'Flank	INS	-	T	T																															gtagtttctaaccgtaagggINSttttttttttttttgaggcg																								rs61603783		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:25727627_25727628insT	uc003nfc.2	-							NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa						nucleosome assembly	nucleosome|nucleus	DNA binding				0						AACCGTAAGGGttttttttttt	0.203													---	---	---								T	25727628	T	T	25727627	6	5	128	0	1	1	1	0	0	0	0	0	7167	1276	44	0		0	HIST1H2AA	6	25727627	5'Flank	INS	-	TCGA-CR-6481-01A-11D-1870-08	18156912	25727627	145387440	193	22807											
HIST1H2AC	8334	broad.mit.edu	37	chr6	26124697	26124697	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaacaagaagactcgcatCatcccgcgccacttgcagct	12	6	8	15	3	1	2	1	0	0	2	3	3	2	2	2	0	3	3	2	0	3	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:26124697C>T	uc003ngm.2	+	1	325	c.237C>T	c.(235-237)ATC>ATT	p.I79I	HIST1H2BC_uc003ngk.3_5'Flank|HIST1H2BC_uc003ngl.2_5'Flank|HIST1H2AC_uc003ngn.2_RNA|HIST1H2AC_uc003ngo.2_RNA|HIST1H2AC_uc003ngp.2_Silent_p.I79I	NM_003512	NP_003503	Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	79					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGACTCGCATCATCCCGCGCC	0.642													21	109					0	0	0	0	T	26124697	T	T	26124697	2	4	128	1	0	0	0	0	0	0	0	1	7169	816	29	2		2	HIST1H2AC	6	26124697	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	397070	26124697	144990370	194	22808											
BTN3A1	11119	broad.mit.edu	37	chr6	26413881	26413881	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatcctgttttcagaattttGaccttggagcccacggccct	7	14	8	12	1	1	2	1	1	0	1	2	3	2	3	4	2	1	1	4	2	2	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:26413881G>C	uc003nhv.2	+	10	1871	c.1503G>C	c.(1501-1503)TTG>TTC	p.L501F	BTN3A1_uc011dkj.1_3'UTR|BTN3A1_uc011dkk.1_Missense_Mutation_p.L449F|BTN3A1_uc010jqj.2_3'UTR	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	501	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TCAGAATTTTGACCTTGGAGC	0.463													18	121					0	0	0	0	C	26413881	C	C	26413881	3	2	128	1	0	0	0	0	1	0	0	0	1567	1281	45	2	1705	2	BTN3A1	6	26413881	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	289184	26413881	144701186	195	22809											
BTN2A1	11120	broad.mit.edu	37	chr6	26463541	26463541	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catccggctggagtgcatatCtagagggtggtacccaaagc	10	8	13	10	1	1	1	0	0	1	1	2	2	2	2	2	4	3	3	2	4	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:26463541C>T	uc003nib.1	+	4	712	c.500C>T	c.(499-501)TCT>TTT	p.S167F	BTN2A1_uc003nic.1_Missense_Mutation_p.S167F|BTN2A1_uc003nid.1_Missense_Mutation_p.S15F|BTN2A1_uc011dko.1_Missense_Mutation_p.S106F|BTN2A1_uc010jqk.1_5'Flank	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	167	Extracellular (Potential).				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						GAGTGCATATCTAGAGGGTGG	0.587													9	74					0	0	0	0	T	26463541	T	T	26463541	3	4	128	1	0	0	0	0	1	0	0	0	1565	913	32	2	510	2	BTN2A1	6	26463541	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	49660	26463541	144651526	196	22810											
HIST1H3I	8354	broad.mit.edu	37	chr6	27839889	27839889	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatctcccgtaccaagcgctGaaaaggtagcttccggatta	11	9	10	11	3	1	1	0	1	1	0	3	3	2	2	3	2	3	4	3	2	6	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:27839889G>A	uc003njy.2	-	1	211	c.205C>T	c.(205-207)CAG>TAG	p.Q69*		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	69					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						ACCAAGCGCTGAAAAGGTAGC	0.637													32	92					0	0	0	0	A	27839889	A	A	27839889	4	1	128	1	0	0	0	0	0	1	0	0	7202	1299	45	2	209	2	HIST1H3I	6	27839889	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1376348	27839889	143275178	197	22811											
CDSN	1041	broad.mit.edu	37	chr6	31084503	31084503	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaggagccacccaccacctCgtagccaccataggatttgt	11	7	9	14	1	0	1	0	0	0	1	1	3	0	3	6	2	2	1	6	2	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:31084503C>T	uc003nsm.1	-	2	916	c.889G>A	c.(889-891)GAG>AAG	p.E297K	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	297	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						CCCACCACCTCGTAGCCACCA	0.547													5	41					0	0	0	0	T	31084503	T	T	31084503	3	4	128	1	0	0	0	0	1	0	0	0	3194	893	31	1	704	1	CDSN	6	31084503	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3244614	31084503	140030564	198	22812											
HLA-B	3106	broad.mit.edu	37	chr6	31324665	31324665	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcgtccacgtagcccactGagatgaagcggggctccccg	7	7	13	14	4	0	2	0	2	0	1	3	3	2	2	4	2	2	2	4	2	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:31324665G>T	uc003nth.2	-	2	197	c.143C>A	c.(142-144)TCA>TAA	p.S48*	HLA-C_uc003ntb.2_5'Flank|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_5'Flank|HLA-B_uc011dnk.1_5'Flank|HLA-B_uc003ntf.2_Nonsense_Mutation_p.S48*|HLA-B_uc003ntg.1_5'Flank|HLA-B_uc003nti.1_5'Flank|HLA-B_uc010jsn.1_5'Flank|HLA-B_uc010jso.2_Nonsense_Mutation_p.S20*	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	48	Alpha-1.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						GTAGCCCACTGAGATGAAGCG	0.697									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				8	24					5.18039e-06	5.40101e-06	1	0	T	31324665	T	T	31324665	4	4	128	1	0	0	0	0	0	1	0	0	7235	1294	45	2	969	2	HLA-B	6	31324665	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	240162	31324665	139790402	199	22813											
C6orf47	57827	broad.mit.edu	37	chr6	31627496	31627496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tagctgctcaacttggggctCctccttgcttggttcggaag	5	13	12	11	1	1	0	1	0	0	0	4	1	3	1	2	4	4	5	2	4	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:31627496C>T	uc003nvm.1	-	1	1054	c.229G>A	c.(229-231)GAG>AAG	p.E77K		NM_021184	NP_067007	O95873	CF047_HUMAN	G4 protein	77										ovary(1)	1						ACTTGGGGCTCCTCCTTGCTT	0.562													4	48					0	0	0	0	T	31627496	T	T	31627496	3	4	128	1	0	0	0	0	1	0	0	0	2374	864	30	2	659	2	C6orf47	6	31627496	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	302831	31627496	139487571	200	22814											
EHMT2	10919	broad.mit.edu	37	chr6	31856391	31856391	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccacctctccgtccacactCtcagtggccatgcacttgtg	6	10	7	18	1	2	0	1	0	2	0	5	0	3	0	5	1	1	1	5	1	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:31856391C>G	uc003nxz.1	-	11	1360	c.1350G>C	c.(1348-1350)GAG>GAC	p.E450D	EHMT2_uc003nxy.1_Missense_Mutation_p.E241D|EHMT2_uc011don.1_Missense_Mutation_p.E473D|EHMT2_uc003nya.1_Missense_Mutation_p.E416D	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	450					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CGTCCACACTCTCAGTGGCCA	0.662													4	31					0	0	0	0	G	31856391	G	G	31856391	3	3	128	1	0	0	0	0	1	0	0	0	5006	912	32	2	2354	2	EHMT2	6	31856391	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	228895	31856391	139258676	201	22815											
TNXB	7148	broad.mit.edu	37	chr6	32050002	32050002	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaggtgtcaaactggccctCagggacagtccaggagaggt	11	6	15	9	0	2	1	2	0	0	1	3	4	3	2	2	5	1	0	2	5	2	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:32050002C>T	uc003nzl.2	-	9	3749	c.3547G>A	c.(3547-3549)GAG>AAG	p.E1183K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1270	Fibronectin type-III 5.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AACTGGCCCTCAGGGACAGTC	0.602													5	47					0	0	0	0	T	32050002	T	T	32050002	3	4	128	1	0	0	0	0	1	0	0	0	16412	835	29	2	11310	2	TNXB	6	32050002	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	193611	32050002	139065065	202	22816											
ITPR3	3710	broad.mit.edu	37	chr6	33660549	33660549	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctatgacctcctgttcttCttcatcgtcatcatcattgt	6	18	5	12	1	7	1	4	1	3	0	9	1	8	1	2	0	0	1	2	0	1	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:33660549C>T	uc011drk.1	+	55	7722	c.7503C>T	c.(7501-7503)TTC>TTT	p.F2501F	ITPR3_uc003oey.2_Silent_p.F588F	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2501	Helical; (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TCCTGTTCTTCTTCATCGTCA	0.547													17	87					0	0	0	0	T	33660549	T	T	33660549	2	4	128	1	0	0	0	0	0	0	0	1	7961	912	32	2		2	ITPR3	6	33660549	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1610547	33660549	137454518	203	22817											
UHRF1BP1	54887	broad.mit.edu	37	chr6	34839420	34839420	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atccccatcactctggccatGgaacatgttgtgctgaagag	10	10	10	11	0	2	2	1	1	1	1	3	3	3	3	3	2	2	2	3	2	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:34839420G>A	uc003oju.3	+	19	4275	c.4041G>A	c.(4039-4041)ATG>ATA	p.M1347I	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1347										ovary(3)	3						CTCTGGCCATGGAACATGTTG	0.522													10	53					0	0	0	0	A	34839420	A	A	34839420	3	1	128	1	0	0	0	0	1	0	0	0	17036	1348	47	4	4115	4	UHRF1BP1	6	34839420	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1178871	34839420	136275647	204	22818											
MTCH1	23787	broad.mit.edu	37	chr6	36938202	36938202	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgcagttgttcacagccatGaggtcgccaactagcaggaa	11	7	11	12	2	1	1	1	1	0	0	2	2	1	2	3	2	3	4	3	2	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:36938202G>A	uc003ond.1	-	10	1002	c.1002C>T	c.(1000-1002)CTC>CTT	p.L334L	MTCH1_uc003onc.1_Silent_p.L317L|MTCH1_uc010jwo.1_RNA|MTCH1_uc003one.3_Silent_p.L334L|MTCH1_uc011dtt.1_Silent_p.L149L	NM_014341	NP_055156	Q9NZJ7	MTCH1_HUMAN	mitochondrial carrier homolog 1	334	Helical; (Potential).				activation of caspase activity|neuronal ion channel clustering|positive regulation of apoptosis|regulation of signal transduction|transport	integral to membrane|mitochondrial inner membrane	protein binding				0						TCACAGCCATGAGGTCGCCAA	0.622													10	52					0	0	0	0	A	36938202	A	A	36938202	2	1	128	1	0	0	0	0	0	0	0	1	9966	1277	45	2		2	MTCH1	6	36938202	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2098782	36938202	134176865	205	22819											
PTK7	5754	broad.mit.edu	37	chr6	43098331	43098331	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccatgttccattgccagttCtcagcccagccacccccgag	7	8	8	18	1	1	0	1	0	1	0	3	1	2	0	7	0	3	2	7	0	0	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:43098331C>T	uc003oub.1	+	5	942	c.744C>T	c.(742-744)TTC>TTT	p.F248F	PTK7_uc003ouc.1_Silent_p.F248F|PTK7_uc003oud.1_Silent_p.F248F|PTK7_uc003oue.1_Silent_p.F248F|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Silent_p.F256F|PTK7_uc010jyj.1_5'Flank|PTK7_uc003oua.2_Silent_p.F248F	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	248	Ig-like C2-type 3.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			ATTGCCAGTTCTCAGCCCAGC	0.582													3	32					0	0	0	0	T	43098331	T	T	43098331	2	4	128	1	0	0	0	0	0	0	0	1	12828	912	32	2		2	PTK7	6	43098331	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	6160129	43098331	128016736	206	22820											
MUT	4594	broad.mit.edu	37	chr6	49415427	49415427	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttcgcactgaagtattatCaattgccagaacttctacag	12	13	7	9	1	2	2	1	1	1	1	3	2	2	2	1	0	3	3	1	0	6	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:49415427C>T	uc003ozg.3	-	8	1771	c.1516G>A	c.(1516-1518)GAT>AAT	p.D506N		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	506					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAAGTATTATCAATTGCCAGA	0.269													13	70					0	0	0	0	T	49415427	T	T	49415427	3	4	128	1	0	0	0	0	1	0	0	0	10044	826	29	2	760	2	MUT	6	49415427	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	6317096	49415427	121699640	207	22821											
EYS	346007	broad.mit.edu	37	chr6	66204659	66204659	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggtttaaaagaacatgcAtcaagttcctggcagtattt	13	13	8	7	0	1	1	1	0	0	1	2	1	2	1	1	2	2	5	1	2	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:66204659A>G	uc011dxu.1	-	4	1183	c.645T>C	c.(643-645)GAT>GAC	p.D215D	EYS_uc003peq.2_Silent_p.D215D|EYS_uc003per.1_Silent_p.D215D|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	215	EGF-like 2.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						AAGAACATGCATCAAGTTCCT	0.388													3	21					0	0	0	0	G	66204659	G	G	66204659	2	3	128	1	0	0	0	0	0	0	0	1	5357	214	8	5		5	EYS	6	66204659	Silent	SNP	A	TCGA-CR-6481-01A-11D-1870-08	16789232	66204659	104910408	208	22822											
C6orf165	154313	broad.mit.edu	37	chr6	88144769	88144769	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaacatttattccatattctCaggtaagcagggtcaatatt	14	14	6	7	0	2	0	2	0	1	0	4	0	3	0	1	2	2	2	1	2	6	8			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:88144769C>T	uc003plv.2	+	11	1584	c.1492C>T	c.(1492-1494)CAG>TAG	p.Q498*	SLC35A1_uc003plx.2_5'Flank|C6orf165_uc003plw.2_Nonsense_Mutation_p.Q310*|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Nonsense_Mutation_p.Q498*	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	498										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TCCATATTCTCAGGTAAGCAG	0.284													6	56					0	0	0	0	T	88144769	T	T	88144769	4	4	128	1	0	0	0	0	0	1	0	0	2351	827	29	2	1530	2	C6orf165	6	88144769	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	21940110	88144769	82970298	209	22823											
MDN1	23195	broad.mit.edu	37	chr6	90472197	90472197	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtctgagcaaagagttcctCaaatgcctcccgtaagggta	11	10	10	10	1	2	2	1	1	1	1	4	2	4	2	3	1	2	4	3	1	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:90472197C>G	uc003pnn.1	-	16	2313	c.2197G>C	c.(2197-2199)GAG>CAG	p.E733Q	MDN1_uc003pno.1_Missense_Mutation_p.E151Q	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	733					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AAGAGTTCCTCAAATGCCTCC	0.423													4	75					0	0	0	0	G	90472197	G	G	90472197	3	3	128	1	0	0	0	0	1	0	0	0	9468	835	29	2	14941	2	MDN1	6	90472197	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2327428	90472197	80642870	210	22824											
FBXL4	26235	broad.mit.edu	37	chr6	99347183	99347183	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaacaagtcgtttaaggctGcataacttggcaatgtggtt	12	12	11	6	1	0	1	0	0	0	1	1	1	0	1	0	3	3	5	0	3	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:99347183G>A	uc003ppf.1	-	6	1636	c.1278C>T	c.(1276-1278)TGC>TGT	p.C426C	FBXL4_uc003ppg.1_Silent_p.C426C|FBXL4_uc003pph.1_Silent_p.C28C|FBXL4_uc010kcp.2_Silent_p.C28C	NM_012160	NP_036292	Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	426					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				skin(2)	2		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		GTTTAAGGCTGCATAACTTGG	0.378													14	78					0	0	0	0	A	99347183	A	A	99347183	2	1	128	1	0	0	0	0	0	0	0	1	5753	1311	46	4		4	FBXL4	6	99347183	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	8874986	99347183	71767884	211	22825											
AIM1	202	broad.mit.edu	37	chr6	106999740	106999740	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttagatgggtagcctatGaaaatcctgacttcacagga	12	12	9	8	0	2	3	1	2	1	1	3	4	3	4	2	2	1	1	2	2	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:106999740G>A	uc003prh.2	+	12	4589	c.4102G>A	c.(4102-4104)GAA>AAA	p.E1368K	AIM1_uc003pri.2_Missense_Mutation_p.E172K	NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1368	Beta/gamma crystallin 'Greek key' 8.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		GGTAGCCTATGAAAATCCTGA	0.338													25	159					0	0	0	0	A	106999740	A	A	106999740	3	1	128	1	0	0	0	0	1	0	0	0	430	1291	45	2	4148	2	AIM1	6	106999740	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7652557	106999740	64115327	212	22826											
FAM26D	221301	broad.mit.edu	37	chr6	116879267	116879267	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagatatttcagtacccactCttttatgcatgggtgatgac	11	14	8	8	0	2	3	1	2	1	1	2	3	2	3	1	1	2	2	1	1	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:116879267C>G	uc003pxa.2	+	4	708	c.409C>G	c.(409-411)CTT>GTT	p.L137V	FAM26D_uc003pwz.2_Missense_Mutation_p.L94V|FAM26D_uc010ked.2_Missense_Mutation_p.L136V	NM_153036	NP_694581	Q5JW98	FA26D_HUMAN	hypothetical protein LOC221301	280						integral to membrane					0		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0458)|OV - Ovarian serous cystadenocarcinoma(136;0.0694)|Epithelial(106;0.222)		AGTACCCACTCTTTTATGCAT	0.423													16	113					0	0	0	0	G	116879267	G	G	116879267	3	3	128	1	0	0	0	0	1	0	0	0	5581	913	32	2	282	2	FAM26D	6	116879267	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	9879527	116879267	54235800	213	22827											
ZUFSP	221302	broad.mit.edu	37	chr6	116988128	116988128	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactgtagggtgttgtctttCttgttatctgaagttccata	7	18	9	7	0	3	1	0	1	3	0	4	1	4	1	1	1	0	4	1	1	4	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:116988128C>T	uc003pxf.1	-	2	474	c.228G>A	c.(226-228)AAG>AAA	p.K76K	ZUFSP_uc010kef.1_Intron	NM_145062	NP_659499	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	76						intracellular	zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		TGTTGTCTTTCTTGTTATCTG	0.338													15	83					0	0	0	0	T	116988128	T	T	116988128	2	4	128	1	0	0	0	0	0	0	0	1	18313	912	32	2		2	ZUFSP	6	116988128	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	108861	116988128	54126939	214	22828											
EYA4	2070	broad.mit.edu	37	chr6	133783787	133783787	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgatgttgccagccatcaaGacagagagtggactttccca	11	9	11	10	0	1	3	1	1	0	2	2	5	2	4	3	1	2	1	3	1	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:133783787G>A	uc003qec.3	+	9	1067	c.609G>A	c.(607-609)AAG>AAA	p.K203K	EYA4_uc011ecq.1_Silent_p.K149K|EYA4_uc011ecr.1_Silent_p.K149K|EYA4_uc003qed.3_Silent_p.K203K|EYA4_uc003qee.3_Silent_p.K180K|EYA4_uc011ecs.1_Silent_p.K203K|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	203					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CAGCCATCAAGACAGAGAGTG	0.438													9	56					0	0	0	0	A	133783787	A	A	133783787	2	1	128	1	0	0	0	0	0	0	0	1	5356	933	33	2		2	EYA4	6	133783787	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	16795659	133783787	37331280	215	22829											
IFNGR1	3459	broad.mit.edu	37	chr6	137527279	137527279	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacattctactcaccatctcGgcatacagcaaattcttctg	11	12	4	14	1	5	0	1	0	4	0	6	0	5	0	1	1	3	2	1	1	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:137527279G>A	uc003qho.2	-	3	470	c.367C>T	c.(367-369)CGA>TGA	p.R123*	IFNGR1_uc011edm.1_Nonsense_Mutation_p.R95*|IFNGR1_uc011edn.1_Nonsense_Mutation_p.R113*	NM_000416	NP_000407	P15260	INGR1_HUMAN	interferon gamma receptor 1 precursor	123	Extracellular (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	TCACCATCTCGGCATACAGCA	0.348													14	76					0	0	0	0	A	137527279	A	A	137527279	4	1	128	1	0	0	0	0	0	1	0	0	7588	1124	39	1	1122	1	IFNGR1	6	137527279	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3743492	137527279	33587788	216	22830											
TNFAIP3	7128	broad.mit.edu	37	chr6	138202334	138202334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccctggggcccaccggggtGagcctgcccccgaagacccc	5	3	14	19	2	0	2	0	1	0	1	0	3	0	2	8	4	2	0	8	4	1	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:138202334G>A	uc003qhr.2	+	9	2317	c.2251G>A	c.(2251-2253)GAG>AAG	p.E751K	TNFAIP3_uc003qhs.2_Missense_Mutation_p.E751K	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	751	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)|p.E751K(1)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		CCACCGGGGTGAGCCTGCCCC	0.647			D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								5	64					0	0	0	0	A	138202334	A	A	138202334	3	1	128	1	0	0	0	0	1	0	0	0	16340	1291	45	2	2281	2	TNFAIP3	6	138202334	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	675055	138202334	32912733	217	22831											
PRPS1L1	221823	broad.mit.edu	37	chr7	18066763	18066763	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatctacaaggatagccaCacgatcattcacatctccca	13	9	5	14	1	5	0	3	0	2	0	6	2	5	1	2	1	2	0	2	1	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:18066763C>T	uc003stz.2	-	1	724	c.643G>A	c.(643-645)GTG>ATG	p.V215M		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	215	Binding of phosphoribosylpyrophosphate (Potential).				nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					AGGATAGCCACACGATCATTC	0.453													23	99					0	0	0	0	T	18066763	T	T	18066763	3	4	128	1	0	0	0	0	1	0	0	0	12641	478	17	4	317	4	PRPS1L1	7	18066763	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08		18066763	141071900	218	22832											
DNAH11	8701	broad.mit.edu	37	chr7	21781778	21781778	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagagatttatcaaacgtCttccaggtaccttgactgct	10	13	8	10	1	2	3	1	2	1	1	3	4	3	3	2	1	3	2	2	1	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:21781778C>T	uc003svc.2	+	50	8200	c.8169C>T	c.(8167-8169)GTC>GTT	p.V2723V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2723	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TATCAAACGTCTTCCAGGTAC	0.294									Kartagener_syndrome				13	45					0	0	0	0	T	21781778	T	T	21781778	2	4	128	1	0	0	0	0	0	0	0	1	4621	900	32	2		2	DNAH11	7	21781778	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3715015	21781778	137356885	219	22833											
EPDR1	54749	broad.mit.edu	37	chr7	37989863	37989863	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtccaggaaacctttacCataaactacagtgtgatatt	13	12	6	10	0	0	1	0	1	0	0	1	2	1	2	4	1	4	0	4	1	6	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:37989863C>A	uc003tfp.2	+	3	919	c.900C>A	c.(898-900)ACC>ACA	p.T300T	EPDR1_uc003tfq.2_3'UTR|EPDR1_uc010kxh.2_Silent_p.T119T	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	180					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						AAACCTTTACCATAAACTACA	0.428													4	41					0.00116845	0.00119189	1	0	A	37989863	A	A	37989863	2	1	128	1	0	0	0	0	0	0	0	1	5187	581	21	4		4	EPDR1	7	37989863	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	16208085	37989863	121148800	220	22834											
VPS41	27072	broad.mit.edu	37	chr7	38796440	38796440	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaataaaaagcacattacctCtgaatcaaaatccattaata	21	10	2	8	0	2	1	1	1	1	0	3	1	3	1	2	0	2	1	2	0	10	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:38796440C>G	uc003tgy.2	-	19	1719	c.1693G>C	c.(1693-1695)GAG>CAG	p.E565Q	VPS41_uc003tgz.2_Missense_Mutation_p.E540Q|VPS41_uc010kxn.2_Missense_Mutation_p.E476Q	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	565					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						CACATTACCTCTGAATCAAAA	0.269													3	20					0	0	0	0	G	38796440	G	G	38796440	3	3	128	1	0	0	0	0	1	0	0	0	17278	922	32	2	915	2	VPS41	7	38796440	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	806577	38796440	120342223	221	22835											
ZNF713	349075	broad.mit.edu	37	chr7	56007242	56007242	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctataagtgtgatgaatgtgGaaaaagattcagccagagga	16	9	12	4	0	1	4	1	2	0	2	1	6	1	6	1	2	1	0	1	2	5	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:56007242G>A	uc003trc.1	+	4	874	c.836G>A	c.(835-837)GGA>GAA	p.G279E	ZNF713_uc003tra.1_Missense_Mutation_p.G292E|MRPS17_uc003trb.2_Intron	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	279	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GATGAATGTGGAAAAAGATTC	0.458													8	52					0	0	0	0	A	56007242	A	A	56007242	3	1	128	1	0	0	0	0	1	0	0	0	18184	1174	41	2	850	2	ZNF713	7	56007242	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	17210802	56007242	103131421	222	22836											
PTPN12	5782	broad.mit.edu	37	chr7	77256781	77256781	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccactcttcagaacacccctCagttttactaatccacttca	11	12	2	16	0	4	1	3	0	1	1	5	1	5	1	4	0	2	1	4	0	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:77256781C>T	uc003ugh.2	+	13	1876	c.1785C>T	c.(1783-1785)CTC>CTT	p.L595L	PTPN12_uc011kgp.1_Silent_p.L476L|PTPN12_uc011kgq.1_Silent_p.L465L|PTPN12_uc010lds.2_Silent_p.L327L	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	595						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						GAACACCCCTCAGTTTTACTA	0.403													19	160					0	0	0	0	T	77256781	T	T	77256781	2	4	128	1	0	0	0	0	0	0	0	1	12844	813	29	2		2	PTPN12	7	77256781	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	21249539	77256781	81881882	223	22837											
STEAP2	261729	broad.mit.edu	37	chr7	89856767	89856767	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacagcctctgcttaccgatGagaaggtcagagagatattt	12	11	10	8	1	2	3	1	1	1	3	2	6	2	3	2	1	4	1	2	1	4	4	rs151250725		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:89856767G>C	uc003ujz.2	+	3	1368	c.975G>C	c.(973-975)ATG>ATC	p.M325I	STEAP2_uc003ujy.2_Missense_Mutation_p.M367I|STEAP2_uc010len.2_Missense_Mutation_p.M325I|STEAP2_uc003uka.2_Missense_Mutation_p.M325I|STEAP2_uc003ukb.2_Missense_Mutation_p.M325I|STEAP2_uc003ukc.2_Missense_Mutation_p.M325I|STEAP2_uc003ukd.2_Missense_Mutation_p.M325I	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	325	Ferric oxidoreductase.|Helical; (Potential).				electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					GCTTACCGATGAGAAGGTCAG	0.383													10	40					0	0	0	0	C	89856767	C	C	89856767	3	2	128	1	0	0	0	0	1	0	0	0	15344	1290	45	2	981	2	STEAP2	7	89856767	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	12599986	89856767	69281896	224	22838											
HEPACAM2	253012	broad.mit.edu	37	chr7	92838091	92838091	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttggggggatgagaatcagCagaacaatcaaataggatgg	15	7	15	4	0	2	2	2	1	0	2	2	5	2	4	0	5	2	2	0	5	5	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:92838091C>T	uc003umm.2	-	4	837	c.814G>A	c.(814-816)GCT>ACT	p.A272T	HEPACAM2_uc003uml.2_Missense_Mutation_p.A260T|HEPACAM2_uc010lff.2_Missense_Mutation_p.A260T|HEPACAM2_uc011khy.1_Missense_Mutation_p.A295T	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	272	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						TGAGAATCAGCAGAACAATCA	0.433													14	78					0	0	0	0	T	92838091	T	T	92838091	3	4	128	1	0	0	0	0	1	0	0	0	7092	710	25	4	602	4	HEPACAM2	7	92838091	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2981324	92838091	66300572	225	22839											
ZAN	7455	broad.mit.edu	37	chr7	100344231	100344231	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgtcctcctgagccccgtGagcctgtcctctggctgtct	2	12	11	16	1	2	2	0	2	2	0	5	2	5	2	6	1	2	2	6	1	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:100344231G>A	uc003uwj.2	+	8	1002	c.837G>A	c.(835-837)GTG>GTA	p.V279V	ZAN_uc003uwk.2_Silent_p.V279V|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	279	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGAGCCCCGTGAGCCTGTCCT	0.572													9	95					0	0	0	0	A	100344231	A	A	100344231	2	1	128	1	0	0	0	0	0	0	0	1	17581	1277	45	2		2	ZAN	7	100344231	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7506140	100344231	58794432	226	22840											
C7orf52	375607	broad.mit.edu	37	chr7	100816658	100816658	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccgtgccaccttgaccccCgggtgctgtctcttgaccag	5	9	11	16	2	1	2	0	2	1	0	2	2	1	2	6	1	3	1	6	1	0	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:100816658C>A	uc003uxy.1	-	3	695	c.456G>T	c.(454-456)CCG>CCT	p.P152P	C7orf52_uc003uxz.1_Silent_p.P152P	NM_198571	NP_940973	Q8N8M0	CG052_HUMAN	hypothetical protein LOC375607	152	N-acetyltransferase.						N-acetyltransferase activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					CCTTGACCCCCGGGTGCTGTC	0.687													14	42					7.93312e-07	8.31029e-07	1	0	A	100816658	A	A	100816658	2	1	128	1	0	0	0	0	0	0	0	1	2412	639	23	3		3	C7orf52	7	100816658	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	472427	100816658	58322005	227	22841											
CUX1	1523	broad.mit.edu	37	chr7	101844841	101844841	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctcgcccatgcccaccgtgtCcagctacccacctctcgcca	6	7	6	22	3	1	0	0	0	1	0	4	0	2	0	7	0	3	1	7	0	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:101844841C>G	uc003uyx.3	+	18	2302	c.2264C>G	c.(2263-2265)TCC>TGC	p.S755C	CUX1_uc003uys.3_Missense_Mutation_p.S766C|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	755					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CCCACCGTGTCCAGCTACCCA	0.647													21	110					0	0	0	0	G	101844841	G	G	101844841	3	3	128	1	0	0	0	0	1	0	0	0	4081	855	30	2	2401	2	CUX1	7	101844841	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1028183	101844841	57293822	228	22842											
NRCAM	4897	broad.mit.edu	37	chr7	107822288	107822288	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatagccttgtaggtgtcctCggatgcttttcagaggtact	7	14	12	8	1	1	1	1	0	0	1	3	3	2	2	2	3	3	3	2	3	3	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:107822288C>T	uc003vfb.2	-	24	3095	c.2624G>A	c.(2623-2625)CGA>CAA	p.R875Q	NRCAM_uc003vfc.2_Missense_Mutation_p.R859Q|NRCAM_uc011kmk.1_Missense_Mutation_p.R870Q|NRCAM_uc003vfd.2_Missense_Mutation_p.R851Q|NRCAM_uc003vfe.2_Missense_Mutation_p.R851Q	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	875	Fibronectin type-III 3.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TAGGTGTCCTCGGATGCTTTT	0.527													11	38					0	0	0	0	T	107822288	T	T	107822288	3	4	128	1	0	0	0	0	1	0	0	0	10698	884	31	1	1360	1	NRCAM	7	107822288	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5977447	107822288	51316375	229	22843											
EXOC4	60412	broad.mit.edu	37	chr7	133041328	133041328	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	actgtggagaaccaaccaagGtaggtgggagtgtattttgt	11	11	14	5	0	0	1	0	0	0	1	0	3	0	2	2	4	2	2	2	4	5	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:133041328G>A	uc003vrk.2	+	6	1042	c.1007_splice	c.e6+1	p.R336_splice	EXOC4_uc011kpo.1_Splice_Site_p.R235_splice|EXOC4_uc003vri.2_Splice_Site_p.R336_splice|EXOC4_uc003vrj.2_Splice_Site_p.R336_splice	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a						vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				ACCAACCAAGGTAGGTGGGAG	0.448													3	32					0	0	0	0	A	133041328	A	A	133041328	5	1	128	1	0	0	0	0	0	0	1	0	5330	1275	44	4	1030	4	EXOC4	7	133041328	Splice_Site	SNP	G	TCGA-CR-6481-01A-11D-1870-08	25219040	133041328	26097335	230	22844											
WEE2	494551	broad.mit.edu	37	chr7	141422958	141422958	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtttgcaagctgctatatCtgaaaacactaagtctggca	13	11	9	8	0	2	1	0	1	2	0	2	2	2	1	0	1	4	5	0	1	6	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:141422958C>T	uc003vwn.2	+	6	1311	c.905C>T	c.(904-906)TCT>TTT	p.S302F	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	302	Protein kinase.				egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					GCTGCTATATCTGAAAACACT	0.383													20	105					0	0	0	0	T	141422958	T	T	141422958	3	4	128	1	0	0	0	0	1	0	0	0	17413	913	32	2	927	2	WEE2	7	141422958	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	8381630	141422958	17715705	231	22845											
SMARCD3	6604	broad.mit.edu	37	chr7	150936782	150936782	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctctggagaagcttagcatGaagtccctctggatcttgag	9	12	11	9	0	3	3	0	2	3	1	5	5	4	4	1	2	2	2	1	2	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:150936782G>C	uc003wjs.2	-	11	1325	c.1224C>G	c.(1222-1224)TTC>TTG	p.F408L	SMARCD3_uc003wjt.2_Missense_Mutation_p.F395L|SMARCD3_uc003wju.2_Missense_Mutation_p.F395L	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	408					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCTTAGCATGAAGTCCCTCT	0.532													21	98					0	0	0	0	C	150936782	C	C	150936782	3	2	128	1	0	0	0	0	1	0	0	0	14843	1281	45	2	239	2	SMARCD3	7	150936782	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	9513824	150936782	8201881	232	22846											
CSMD1	64478	broad.mit.edu	37	chr8	2836257	2836257	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattccatactcaaaactctCagggaagttctgttgcccgt	10	12	7	12	1	3	0	2	0	2	0	5	1	4	1	2	1	3	2	2	1	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:2836257C>T	uc011kwk.1	-	55	8836	c.8446G>A	c.(8446-8448)GAG>AAG	p.E2816K	CSMD1_uc011kwj.1_Missense_Mutation_p.E2145K|CSMD1_uc010lrg.2_Missense_Mutation_p.E826K	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2816	Extracellular (Potential).|Sushi 20.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCAAAACTCTCAGGGAAGTTC	0.423													3	16					0	0	0	0	T	2836257	T	T	2836257	3	4	128	1	0	0	0	0	1	0	0	0	3961	835	29	2	2315	2	CSMD1	8	2836257	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08		2836257	143527765	233	22847											
RP1L1	94137	broad.mit.edu	37	chr8	10470341	10470341	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccagtccccacctcttccGagctgccactctctctccct	4	10	6	21	1	3	0	0	0	3	0	7	1	5	0	7	1	2	1	7	1	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:10470341G>A	uc003wtc.2	-	4	1496	c.1267C>T	c.(1267-1269)CGG>TGG	p.R423W		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	423					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CACCTCTTCCGAGCTGCCACT	0.667													13	38					0	0	0	0	A	10470341	A	A	10470341	3	1	128	1	0	0	0	0	1	0	0	0	13598	1057	37	1	5939	1	RP1L1	8	10470341	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7634084	10470341	135893681	234	22848											
AMAC1L2	83650	broad.mit.edu	37	chr8	11188898	11188898	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactgcgtggcgacccccttCtgggacctcctgacatccga	7	8	10	16	3	1	1	0	1	1	0	3	4	3	2	5	2	2	0	5	2	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:11188898C>T	uc003wtp.1	+	1	404	c.283C>T	c.(283-285)CTG>TTG	p.L95L		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	95	DUF6 1.					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		CGACCCCCTTCTGGGACCTCC	0.602													35	237					0	0	0	0	T	11188898	T	T	11188898	2	4	128	1	0	0	0	0	0	0	0	1	560	912	32	2		2	AMAC1L2	8	11188898	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	718557	11188898	135175124	235	22849											
SLC7A2	6542	broad.mit.edu	37	chr8	17419529	17419529	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggctggaggcctggagcctCgctctcctcgcgctgtttct	3	11	13	14	3	2	0	0	0	2	0	5	2	2	2	3	4	1	4	3	4	0	1	rs139462829		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:17419529C>T	uc011kyc.1	+	10	1750	c.1581C>T	c.(1579-1581)CTC>CTT	p.L527L	SLC7A2_uc011kyd.1_Silent_p.L566L|SLC7A2_uc011kye.1_Silent_p.L567L|SLC7A2_uc011kyf.1_Silent_p.L527L	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	527	Helical; (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	CCTGGAGCCTCGCTCTCCTCG	0.532													21	70					0	0	0	0	T	17419529	T	T	17419529	2	4	128	1	0	0	0	0	0	0	0	1	14761	871	31	1		1	SLC7A2	8	17419529	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	6230631	17419529	128944493	236	22850											
MTUS1	57509	broad.mit.edu	37	chr8	17613142	17613142	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactacagcagggtcagtttCataatcaaccaccatgtcat	14	10	6	11	0	4	0	4	0	0	0	4	0	4	0	2	1	4	2	2	1	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:17613142C>G	uc003wxv.2	-	2	649	c.175G>C	c.(175-177)GAA>CAA	p.E59Q	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.E59Q|MTUS1_uc010lsz.2_Missense_Mutation_p.E59Q	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	59						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		GGGTCAGTTTCATAATCAACC	0.403													28	168					0	0	0	0	G	17613142	G	G	17613142	3	3	128	1	0	0	0	0	1	0	0	0	10018	835	29	2	4012	2	MTUS1	8	17613142	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	193613	17613142	128750880	237	22851											
DOK2	9046	broad.mit.edu	37	chr8	21767244	21767244	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggcagtgagtcatgcggccGagagtaggggctatcaggcc	8	6	17	10	3	2	2	2	1	0	1	2	3	2	2	2	5	1	3	2	5	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:21767244G>A	uc003wzy.1	-	5	910	c.817C>T	c.(817-819)CGG>TGG	p.R273W	DOK2_uc003wzx.1_Missense_Mutation_p.R273W|DOK2_uc003wzz.1_Missense_Mutation_p.R119W|DOK2_uc010lth.1_Missense_Mutation_p.R119W	NM_003974	NP_003965	O60496	DOK2_HUMAN	docking protein 2	273	Pro-rich.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding				0				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		TCATGCGGCCGAGAGTAGGGG	0.682													6	59					0	0	0	0	A	21767244	A	A	21767244	3	1	128	1	0	0	0	0	1	0	0	0	4719	1057	37	1	425	1	DOK2	8	21767244	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4154102	21767244	124596778	238	22852											
LOXL2	4017	broad.mit.edu	37	chr8	23167319	23167319	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggtctgcgcggctgaggccGagaggcagttctcctccatg	5	8	15	13	4	2	2	0	1	2	1	4	3	3	2	3	4	1	3	3	4	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:23167319G>A	uc003xdh.1	-	10	2081	c.1742C>T	c.(1741-1743)TCG>TTG	p.S581L	LOXL2_uc010lty.1_Missense_Mutation_p.S120L	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	581	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		GGCTGAGGCCGAGAGGCAGTT	0.647													5	25					0	0	0	0	A	23167319	A	A	23167319	3	1	128	1	0	0	0	0	1	0	0	0	8950	1059	37	1	602	1	LOXL2	8	23167319	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1400075	23167319	123196703	239	22853											
LOXL2	4017	broad.mit.edu	37	chr8	23174627	23174627	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tccgtgccaataccaggtctCctggaagaaccaacaaaaca	15	6	7	13	1	1	1	0	0	1	1	3	2	2	2	5	2	5	0	5	2	7	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:23174627C>G	uc003xdh.1	-	9	1810	c.1471G>C	c.(1471-1473)GAG>CAG	p.E491Q	LOXL2_uc010lty.1_Missense_Mutation_p.E30Q	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	491	SRCR 4.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TACCAGGTCTCCTGGAAGAAC	0.388													33	125					0	0	0	0	G	23174627	G	G	23174627	3	3	128	1	0	0	0	0	1	0	0	0	8950	869	30	2	877	2	LOXL2	8	23174627	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	7308	23174627	123189395	240	22854											
HTRA4	203100	broad.mit.edu	37	chr8	38840029	38840029	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttccaggaaaggcgttttCaaataagaaatatctgggtc	13	12	9	7	1	2	1	1	0	1	1	4	2	3	2	1	3	0	1	1	3	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:38840029C>T	uc003xmj.2	+	7	1242	c.1127C>T	c.(1126-1128)TCA>TTA	p.S376L		NM_153692	NP_710159	P83105	HTRA4_HUMAN	HtrA serine peptidase 4 precursor	376					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			AAGGCGTTTTCAAATAAGAAA	0.423													6	56					0	0	0	0	T	38840029	T	T	38840029	3	4	128	1	0	0	0	0	1	0	0	0	7495	838	29	2	1153	2	HTRA4	8	38840029	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	15665402	38840029	107523993	241	22855											
SFRP1	6422	broad.mit.edu	37	chr8	41161008	41161008	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggcacagagatgttcaatGatggcctcagatttcaactc	11	11	9	10	0	3	3	3	1	0	2	4	4	3	3	1	2	1	2	1	2	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:41161008G>C	uc003xnt.2	-	2	896	c.594C>G	c.(592-594)ATC>ATG	p.I198M		NM_003012	NP_003003	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1 precursor	198	NTR.				brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			GATGTTCAATGATGGCCTCAG	0.527													11	36					0	0	0	0	C	41161008	C	C	41161008	3	2	128	1	0	0	0	0	1	0	0	0	14226	1280	45	2	358	2	SFRP1	8	41161008	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2320979	41161008	105203014	242	22856											
ARFGEF1	10565	broad.mit.edu	37	chr8	68131668	68131668	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattgtgtatcctcttacctCtgtctgttgttctggcaatt	6	19	7	9	0	4	0	0	0	4	0	5	0	5	0	2	1	1	4	2	1	4	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:68131668C>T	uc003xxo.1	-	30	4726	c.4336G>A	c.(4336-4338)GAG>AAG	p.E1446K	ARFGEF1_uc003xxl.1_Missense_Mutation_p.E900K|ARFGEF1_uc003xxn.1_Missense_Mutation_p.E429K	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1446					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CCTCTTACCTCTGTCTGTTGT	0.308													3	36					0	0	0	0	T	68131668	T	T	68131668	3	4	128	1	0	0	0	0	1	0	0	0	852	922	32	2	1253	2	ARFGEF1	8	68131668	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	26970660	68131668	78232354	243	22857											
PREX2	80243	broad.mit.edu	37	chr8	69058533	69058533	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcattttgaacaacttcctCaacggctgaaaaatggagga	15	10	8	8	1	2	2	2	2	0	0	3	4	3	4	1	3	3	1	1	3	5	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:69058533C>G	uc003xxv.1	+	34	4204	c.4177C>G	c.(4177-4179)CAA>GAA	p.Q1393E		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1393					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ACAACTTCCTCAACGGCTGAA	0.338													8	46					0	0	0	0	G	69058533	G	G	69058533	3	3	128	1	0	0	0	0	1	0	0	0	12539	827	29	2	4540	2	PREX2	8	69058533	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	926865	69058533	77305489	244	22858											
KCNB2	9312	broad.mit.edu	37	chr8	73850115	73850115	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agataagcctagtgatgggaGagaccctttaagagaagagg	15	7	14	5	0	0	5	0	1	0	4	0	8	0	6	2	2	1	0	2	2	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:73850115G>A	uc003xzb.2	+	3	3113	c.2525G>A	c.(2524-2526)AGA>AAA	p.R842K		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	842	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGTGATGGGAGAGACCCTTTA	0.527													10	71					0	0	0	0	A	73850115	A	A	73850115	3	1	128	1	0	0	0	0	1	0	0	0	8052	942	33	2	2531	2	KCNB2	8	73850115	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4791582	73850115	72513907	245	22859											
ZNF704	619279	broad.mit.edu	37	chr8	81577163	81577163	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtttctgttcggcttgaatCtgggatggggaaagtaggag	9	12	16	4	1	2	1	0	1	2	0	3	4	2	4	0	5	0	4	0	5	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:81577163C>G	uc003yby.1	-	6	1046	c.814G>C	c.(814-816)GAT>CAT	p.D272H		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	272						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			CGGCTTGAATCTGGGATGGGG	0.577													19	107					0	0	0	0	G	81577163	G	G	81577163	3	3	128	1	0	0	0	0	1	0	0	0	18174	913	32	2	440	2	ZNF704	8	81577163	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	7727048	81577163	64786859	246	22860											
VPS13B	157680	broad.mit.edu	37	chr8	100147838	100147838	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcaggaagcctgtttcttCatttgtggtgacaatttgag	8	17	10	6	0	3	2	2	2	1	0	3	3	3	3	1	2	1	1	1	2	2	5	rs141324814	byFrequency	TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:100147838C>T	uc003yiv.2	+	11	1551	c.1440C>T	c.(1438-1440)TTC>TTT	p.F480F	VPS13B_uc003yiw.2_Silent_p.F480F|VPS13B_uc003yit.2_Silent_p.F480F|VPS13B_uc003yiu.1_Silent_p.F480F|VPS13B_uc003yix.1_5'Flank	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	480					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCTGTTTCTTCATTTGTGGTG	0.333													6	39					0	0	0	0	T	100147838	T	T	100147838	2	4	128	1	0	0	0	0	0	0	0	1	17258	825	29	2		2	VPS13B	8	100147838	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	18570675	100147838	46216184	247	22861											
VPS13B	157680	broad.mit.edu	37	chr8	100523503	100523503	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctcctcattttcttcatGaaattcttctttcagcacaa	9	18	3	11	0	7	1	3	1	4	0	8	1	7	1	1	0	1	2	1	0	2	7	rs120074151		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:100523503G>T	uc003yiv.2	+	29	4582	c.4471G>T	c.(4471-4473)GAA>TAA	p.E1491*	VPS13B_uc003yiw.2_Nonsense_Mutation_p.E1466*|VPS13B_uc003yix.1_Nonsense_Mutation_p.E961*	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1491					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTTTCTTCATGAAATTCTTCT	0.333													12	62					0.000978159	0.00100242	1	0	T	100523503	T	T	100523503	4	4	128	1	0	0	0	0	0	1	0	0	17258	1291	45	2	4775	2	VPS13B	8	100523503	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	375665	100523503	45840519	248	22862											
NCALD	83988	broad.mit.edu	37	chr8	102731491	102731491	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctacgtacctgcacgatctCtagcatctctgccttgctga	7	13	7	14	2	3	1	0	1	3	0	5	2	3	1	2	0	6	4	2	0	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:102731491C>G	uc003yke.2	-	2	736	c.367G>C	c.(367-369)GAG>CAG	p.E123Q	NCALD_uc003ykf.2_Missense_Mutation_p.E123Q|NCALD_uc003ykg.2_Missense_Mutation_p.E123Q|NCALD_uc003ykh.2_Missense_Mutation_p.E123Q|NCALD_uc003yki.2_Missense_Mutation_p.E123Q|NCALD_uc003ykj.2_Missense_Mutation_p.E123Q|NCALD_uc003ykk.2_Missense_Mutation_p.E123Q|NCALD_uc003ykl.2_Missense_Mutation_p.E123Q	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	123	EF-hand 3.			E -> V (in Ref. 2; CAB66547).	synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			TGCACGATCTCTAGCATCTCT	0.463													17	100					0	0	0	0	G	102731491	G	G	102731491	3	3	128	1	0	0	0	0	1	0	0	0	10255	922	32	2	226	2	NCALD	8	102731491	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2207988	102731491	43632531	249	22863											
ABRA	137735	broad.mit.edu	37	chr8	107782097	107782097	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaccaccgttttggacacctCtttctttttgatgtgagaaa	9	15	8	9	1	2	2	0	2	2	1	2	5	2	3	3	1	0	1	3	1	1	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:107782097C>G	uc003ymm.3	-	1	376	c.322G>C	c.(322-324)GAG>CAG	p.E108Q		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	108					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			TTGGACACCTCTTTCTTTTTG	0.552													6	137					0	0	0	0	G	107782097	G	G	107782097	3	3	128	1	0	0	0	0	1	0	0	0	100	922	32	2	831	2	ABRA	8	107782097	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5050606	107782097	38581925	250	22864											
NUDCD1	84955	broad.mit.edu	37	chr8	110293297	110293297	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcagtacaatgttgatgtGatcaggcaaaaactgtattt	13	14	8	6	0	2	2	2	2	0	0	2	2	2	2	0	1	2	4	0	1	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:110293297G>A	uc003ynb.3	-	6	1039	c.928C>T	c.(928-930)CAC>TAC	p.H310Y	NUDCD1_uc003yna.2_Missense_Mutation_p.H281Y|NUDCD1_uc010mcl.2_Missense_Mutation_p.H223Y|NUDCD1_uc010mcm.1_Missense_Mutation_p.H223Y	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	310	CS.									ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			ATGTTGATGTGATCAGGCAAA	0.363													10	45					0	0	0	0	A	110293297	A	A	110293297	3	1	128	1	0	0	0	0	1	0	0	0	10776	1290	45	2	843	2	NUDCD1	8	110293297	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2511200	110293297	36070725	251	22865											
PKHD1L1	93035	broad.mit.edu	37	chr8	110497290	110497290	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggagggagaagagattgtGataacaaccacaagctacga	18	5	12	6	1	0	3	0	1	0	2	0	7	0	4	1	2	4	1	1	2	6	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:110497290G>C	uc003yne.2	+	58	9698	c.9594G>C	c.(9592-9594)GTG>GTC	p.V3198V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3198	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAGAGATTGTGATAACAACCA	0.294										HNSCC(38;0.096)			9	48					0	0	0	0	C	110497290	C	C	110497290	2	2	128	1	0	0	0	0	0	0	0	1	12027	1277	45	2		2	PKHD1L1	8	110497290	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	203993	110497290	35866732	252	22866											
RAD21	5885	broad.mit.edu	37	chr8	117874120	117874120	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaaagtcatgaaattcttCaggtaaagtaatggcattat	16	13	7	5	0	4	1	3	1	1	0	4	1	4	1	0	2	0	3	0	2	6	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:117874120C>A	uc003yod.2	-	4	622	c.334G>T	c.(334-336)GAA>TAA	p.E112*		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	112					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TGAAATTCTTCAGGTAAAGTA	0.378													29	144					8.58068e-18	9.25258e-18	1	0	A	117874120	A	A	117874120	4	1	128	1	0	0	0	0	0	1	0	0	13046	835	29	2	1605	2	RAD21	8	117874120	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	7376830	117874120	28489902	253	22867											
SLC30A8	169026	broad.mit.edu	37	chr8	118183390	118183390	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgaatcaagtaattctctCagctcatgttgctacaggtc	12	13	7	9	0	4	1	3	1	1	0	6	1	4	1	0	1	3	4	0	1	5	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:118183390C>T	uc003yoh.2	+	7	1177	c.947C>T	c.(946-948)TCA>TTA	p.S316L	SLC30A8_uc010mcz.2_Missense_Mutation_p.S267L|SLC30A8_uc011lia.1_Missense_Mutation_p.S267L|SLC30A8_uc003yog.2_Missense_Mutation_p.S267L	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	316	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			GTAATTCTCTCAGCTCATGTT	0.423													15	85					0	0	0	0	T	118183390	T	T	118183390	3	4	128	1	0	0	0	0	1	0	0	0	14625	838	29	2	973	2	SLC30A8	8	118183390	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	309270	118183390	28180632	254	22868											
COLEC10	10584	broad.mit.edu	37	chr8	120118062	120118062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagcagggattagggaaactGaagagaaattctactacatc	16	9	10	6	0	1	2	0	1	1	1	2	5	1	4	0	2	4	1	0	2	7	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:120118062G>A	uc003yoo.2	+	6	563	c.466G>A	c.(466-468)GAA>AAA	p.E156K		NM_006438	NP_006429	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 precursor	156	C-type lectin.					collagen|cytoplasm	mannose binding			ovary(2)|skin(1)	3	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			TAGGGAAACTGAAGAGAAATT	0.428													4	26					0	0	0	0	A	120118062	A	A	120118062	3	1	128	1	0	0	0	0	1	0	0	0	3725	1291	45	2	488	2	COLEC10	8	120118062	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1934672	120118062	26245960	255	22869											
ZHX2	22882	broad.mit.edu	37	chr8	123965799	123965799	+	Silent	SNP	G	A	A																															aaggagaacagatgcttgctGaaaacgggaaccgtgaagtg																										TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:123965799G>A	uc003ypk.1	+	3	2616	c.2049G>A	c.(2047-2049)CTG>CTA	p.L683L		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	683	Homeobox 4.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GATGCTTGCTGAAAACGGGAA	0.557													5	51					0	0	0	0	A	123965799	A	A	123965799	2	1	128	1	0	0	0	0	0	0	0	1	17743	1277	45	2		2	ZHX2	8	123965799	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3847737	123965799	22398223	256	22870	48	2									
ZHX2	22882	broad.mit.edu	37	chr8	123965807	123965807	+	Missense_Mutation	SNP	G	C	C																															cagatgcttgctgaaaacggGaaccgtgaagtggatggagc																										TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:123965807G>C	uc003ypk.1	+	3	2624	c.2057G>C	c.(2056-2058)GGA>GCA	p.G686A		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	686	Homeobox 4.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CTGAAAACGGGAACCGTGAAG	0.557													5	52					0	0	0	0	C	123965807	C	C	123965807	3	2	128	1	0	0	0	0	1	0	0	0	17743	1174	41	2	2059	2	ZHX2	8	123965807	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	8	123965807	22398215	257	22871	48	2									
ATAD2	29028	broad.mit.edu	37	chr8	124413317	124413317	+	RNA	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagacatcgactttcttgctGagaaggaccacaccaccctc	11	8	8	14	1	1	2	0	1	1	2	3	6	1	3	3	1	1	1	3	1	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:124413317G>A	uc003yqi.3	-	2		c.202C>T			uc003yqk.2_5'Flank			Q6PL18	ATAD2_HUMAN	Homo sapiens PRO2000 mRNA, complete cds.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CTTTCTTGCTGAGAAGGACCA	0.557													6	34					0	0	0	0	A	124413317	A	A	124413317	1	1	128	0	1	0	0	0	0	0	0	0	1073	1305	45	2		2	ATAD2	8	124413317	RNA	SNP	G	TCGA-CR-6481-01A-11D-1870-08	447510	124413317	21950705	258	22872											
EPPK1	83481	broad.mit.edu	37	chr8	144941998	144941998	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgagctcccgcttcctGtcctctgtgaagtatggaga	7	12	12	10	1	1	3	0	2	1	1	4	5	4	4	3	2	1	3	3	2	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:144941998G>A	uc003zaa.1	-	1	5437	c.5424C>T	c.(5422-5424)GAC>GAT	p.D1808D		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1808						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCGCTTCCTGTCCTCTGTGA	0.527													16	71					0	0	0	0	A	144941998	A	A	144941998	2	1	128	1	0	0	0	0	0	0	0	1	5214	1368	48	4		4	EPPK1	8	144941998	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	20528681	144941998	1422024	259	22873											
SPATC1	375686	broad.mit.edu	37	chr8	145096263	145096263	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctccaacatcccagagaaGatcatccaggtgtgcggcca	11	7	10	13	1	2	2	1	0	1	2	5	3	4	2	4	2	2	0	4	2	2	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:145096263G>C	uc011lkw.1	+	4	1539	c.1437G>C	c.(1435-1437)AAG>AAC	p.K479N	SPATC1_uc011lkx.1_Intron	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	479										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCCCAGAGAAGATCATCCAGG	0.632													6	25					0	0	0	0	C	145096263	C	C	145096263	3	2	128	1	0	0	0	0	1	0	0	0	15083	933	33	2	1451	2	SPATC1	8	145096263	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	154265	145096263	1267759	260	22874											
UHRF2	115426	broad.mit.edu	37	chr9	6506134	6506134	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcccaatgagattctgcaGactctacttgaccttttctt	9	16	5	11	0	3	3	0	2	3	2	4	4	4	3	2	0	2	1	2	0	2	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:6506134G>A	uc003zjy.2	+	16	2704	c.2364G>A	c.(2362-2364)CAG>CAA	p.Q788Q	UHRF2_uc003zjz.2_RNA|UHRF2_uc003zkb.2_RNA	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains	788					cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		AGATTCTGCAGACTCTACTTG	0.463													5	100					0	0	0	0	A	6506134	A	A	6506134	2	1	128	1	0	0	0	0	0	0	0	1	17038	933	33	2		2	UHRF2	9	6506134	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08		6506134	134707297	261	22875											
MTAP	4507	broad.mit.edu	37	chr9	21854777	21854777	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttatcaacatgaccacagttCcagaggtggttcttgctaag	11	12	9	9	0	2	2	1	1	1	1	3	2	3	2	2	2	2	3	2	2	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:21854777C>T	uc003zph.2	+	6	711	c.598C>T	c.(598-600)CCA>TCA	p.P200S	MTAP_uc003zpi.1_Intron|MTAP_uc010mit.2_RNA|MTAP_uc011lnk.1_Missense_Mutation_p.P217S|MTAP_uc011lnl.1_Missense_Mutation_p.P133S	NM_002451	NP_002442	Q13126	MTAP_HUMAN	5'-methylthioadenosine phosphorylase	200					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity			central_nervous_system(1)	1		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	GACCACAGTTCCAGAGGTGGT	0.537													9	58					0	0	0	0	T	21854777	T	T	21854777	3	4	128	1	0	0	0	0	1	0	0	0	9964	855	30	2	620	2	MTAP	9	21854777	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	15348643	21854777	119358654	262	22876											
GBA2	57704	broad.mit.edu	37	chr9	35739738	35739738	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttccagccacactgtgcctCcatcagccaggaagtatagt	10	9	8	14	0	1	0	1	0	0	0	3	1	3	1	5	1	3	1	5	1	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:35739738C>G	uc003zxw.2	-	9	1993	c.1469G>C	c.(1468-1470)GGA>GCA	p.G490A	GBA2_uc003zxx.1_5'Flank|GBA2_uc011lpb.1_Missense_Mutation_p.G490A|GBA2_uc011lpc.1_Missense_Mutation_p.G490A|GBA2_uc011lpd.1_Missense_Mutation_p.G496A|GBA2_uc003zxy.1_Missense_Mutation_p.G203A	NM_020944	NP_065995	Q9HCG7	GBA2_HUMAN	bile acid beta-glucosidase	490	Extracellular (Potential).				bile acid metabolic process|glucosylceramide catabolic process|O-glycoside catabolic process	integral to membrane|microsome|plasma membrane|smooth endoplasmic reticulum	beta-glucosidase activity|glucosylceramidase activity			ovary(3)|skin(1)	4	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CACTGTGCCTCCATCAGCCAG	0.532													7	41					0	0	0	0	G	35739738	G	G	35739738	3	3	128	1	0	0	0	0	1	0	0	0	6302	855	30	2	1350	2	GBA2	9	35739738	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	13884961	35739738	105473693	263	22877											
GBA2	57704	broad.mit.edu	37	chr9	35741858	35741858	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggacttgctggtacacagtCtgcccttcccgacgcaggca	8	8	11	14	2	1	0	0	0	1	0	2	2	2	1	2	3	3	4	2	3	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:35741858C>G	uc003zxw.2	-	4	1121	c.597G>C	c.(595-597)CAG>CAC	p.Q199H	GBA2_uc011lpb.1_Missense_Mutation_p.Q199H|GBA2_uc011lpc.1_Missense_Mutation_p.Q199H|GBA2_uc011lpd.1_Missense_Mutation_p.Q205H|GBA2_uc003zxy.1_5'UTR	NM_020944	NP_065995	Q9HCG7	GBA2_HUMAN	bile acid beta-glucosidase	199	Extracellular (Potential).				bile acid metabolic process|glucosylceramide catabolic process|O-glycoside catabolic process	integral to membrane|microsome|plasma membrane|smooth endoplasmic reticulum	beta-glucosidase activity|glucosylceramidase activity			ovary(3)|skin(1)	4	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GGTACACAGTCTGCCCTTCCC	0.567													3	38					0	0	0	0	G	35741858	G	G	35741858	3	3	128	1	0	0	0	0	1	0	0	0	6302	912	32	2	2242	2	GBA2	9	35741858	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2120	35741858	105471573	264	22878											
NPR2	4882	broad.mit.edu	37	chr9	35806507	35806507	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaggaaaaacgcaaggctGaagctctgctctaccaaatc	14	7	10	10	1	2	1	0	1	2	0	3	3	2	3	1	3	4	4	1	3	6	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:35806507G>A	uc003zyd.2	+	16	2491	c.2491G>A	c.(2491-2493)GAA>AAA	p.E831K	NPR2_uc010mlb.2_Missense_Mutation_p.E807K	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	831	Cytoplasmic (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	ACGCAAGGCTGAAGCTCTGCT	0.517													17	78					0	0	0	0	A	35806507	A	A	35806507	3	1	128	1	0	0	0	0	1	0	0	0	10649	1291	45	2	2553	2	NPR2	9	35806507	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	64649	35806507	105406924	265	22879											
OR13J1	392309	broad.mit.edu	37	chr9	35870019	35870019	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggtacctgagtggctggCagatggccaggtagcggtca	7	8	17	9	2	1	2	1	1	0	1	1	2	1	2	2	6	2	4	2	6	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:35870019C>A	uc011lph.1	-	1	380	c.380G>T	c.(379-381)TGC>TTC	p.C127F		NM_001004487	NP_001004487	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			GAGTGGCTGGCAGATGGCCAG	0.617													10	42					7.48243e-07	7.85061e-07	1	0	A	35870019	A	A	35870019	3	1	128	1	0	0	0	0	1	0	0	0	10998	710	25	4	561	4	OR13J1	9	35870019	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	63512	35870019	105343412	266	22880											
CLTA	1211	broad.mit.edu	37	chr9	36211652	36211652	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgagtcgtccccaggcactGagtgggaacgggtggcccgg	7	5	17	12	4	0	1	0	1	0	0	2	3	1	2	3	5	1	1	3	5	1	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:36211652G>A	uc003zzc.2	+	7	790	c.628G>A	c.(628-630)GAG>AAG	p.E210K	CLTA_uc003zzd.2_Missense_Mutation_p.E198K|CLTA_uc003zze.2_Missense_Mutation_p.E180K|CLTA_uc011lpk.1_Missense_Mutation_p.E192K|CLTA_uc003zzf.1_Intron	NM_007096	NP_009027	P09496	CLCA_HUMAN	clathrin, light polypeptide A isoform b	210					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol	structural molecule activity			central_nervous_system(1)	1			STAD - Stomach adenocarcinoma(86;0.228)			CCCAGGCACTGAGTGGGAACG	0.527													14	115					0	0	0	0	A	36211652	A	A	36211652	3	1	128	1	0	0	0	0	1	0	0	0	3579	1291	45	2	654	2	CLTA	9	36211652	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	341633	36211652	105001779	267	22881											
TRPM6	140803	broad.mit.edu	37	chr9	77354768	77354768	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatcctcagaccaagtgctGacgactctcatagctttacg	10	11	7	13	2	3	2	3	1	1	1	5	3	4	2	2	0	3	2	2	0	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:77354768G>A	uc004ajl.1	-	34	5596	c.5358C>T	c.(5356-5358)GTC>GTT	p.V1786V	TRPM6_uc004ajk.1_Silent_p.V1781V|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Silent_p.V737V|TRPM6_uc010mpd.1_Silent_p.V619V|TRPM6_uc010mpe.1_Silent_p.V333V|TRPM6_uc004ajj.1_Silent_p.V742V	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1786	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						ACCAAGTGCTGACGACTCTCA	0.512													20	109					0	0	0	0	A	77354768	A	A	77354768	2	1	128	1	0	0	0	0	0	0	0	1	16657	1277	45	2		2	TRPM6	9	77354768	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	41143116	77354768	63858663	268	22882											
AGTPBP1	23287	broad.mit.edu	37	chr9	88193845	88193845	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatgttttaccttgtattttCcctgatcacagccacataaa	11	15	5	10	0	1	1	1	1	0	0	2	2	2	1	3	0	2	2	3	0	4	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:88193845C>T	uc011ltd.1	-	23	3365	c.3332G>A	c.(3331-3333)GGA>GAA	p.G1111E	AGTPBP1_uc004aod.3_Missense_Mutation_p.G737E|AGTPBP1_uc011ltc.1_Intron|AGTPBP1_uc010mqc.2_Missense_Mutation_p.G1071E|AGTPBP1_uc011lte.1_Missense_Mutation_p.G1123E	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1111					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						CTTGTATTTTCCCTGATCACA	0.323													18	126					0	0	0	0	T	88193845	T	T	88193845	3	4	128	1	0	0	0	0	1	0	0	0	400	855	30	2	360	2	AGTPBP1	9	88193845	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	10839077	88193845	53019586	269	22883											
C9orf3	84909	broad.mit.edu	37	chr9	97844977	97844977	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ataggtcctcagcccaggtgGtggccgaaatgttattttaa	10	12	11	8	1	1	0	1	0	0	0	2	1	2	0	3	4	1	1	3	4	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:97844977G>T	uc004ava.2	+	15	2575	c.2440G>T	c.(2440-2442)GTG>TTG	p.V814L	C9orf3_uc004auy.2_Missense_Mutation_p.V715L|C9orf3_uc004avc.2_Intron|C9orf3_uc011luj.1_Missense_Mutation_p.V176L|C9orf3_uc011luk.1_Missense_Mutation_p.V155L|C9orf3_uc004avd.2_Missense_Mutation_p.V176L|MIR23B_hsa-mir-23b|MI0000439_5'Flank|uc004avg.3_5'Flank|MIR27B_hsa-mir-27b|MI0000440_5'Flank	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	814					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AGCCCAGGTGGTGGCCGAAAT	0.517													13	50					4.3838e-07	4.62152e-07	1	0	T	97844977	T	T	97844977	3	4	128	1	0	0	0	0	1	0	0	0	2489	1261	44	4	2193	4	C9orf3	9	97844977	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	9651132	97844977	43368454	270	22884											
PTCH1	5727	broad.mit.edu	37	chr9	98242295	98242295	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgactgtgccacccacaatCaactcctcctgccagtgcat	9	10	6	16	0	1	1	1	1	0	0	3	1	3	1	5	0	4	1	5	0	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:98242295C>G	uc004avk.3	-	7	1211	c.1023G>C	c.(1021-1023)TTG>TTC	p.L341F	PTCH1_uc010mro.2_Missense_Mutation_p.L190F|PTCH1_uc010mrp.2_Missense_Mutation_p.L190F|PTCH1_uc010mrq.2_Missense_Mutation_p.L190F|PTCH1_uc004avl.3_Missense_Mutation_p.L190F|PTCH1_uc010mrr.2_Missense_Mutation_p.L275F|PTCH1_uc004avm.3_Missense_Mutation_p.L340F|PTCH1_uc010mrs.1_Missense_Mutation_p.L61F	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	341	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.L341F(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CACCCACAATCAACTCCTCCT	0.458									Basal_Cell_Nevus_syndrome				30	110					0	0	0	0	G	98242295	G	G	98242295	3	3	128	1	0	0	0	0	1	0	0	0	12792	825	29	2	3388	2	PTCH1	9	98242295	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	397318	98242295	42971136	271	22885											
FOXE1	2304	broad.mit.edu	37	chr9	100616544	100616544	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttcctcaagatcccgcgCgaggccggccgcccgggtaa	6	6	13	16	6	1	1	1	0	0	1	3	2	3	1	5	3	1	2	5	3	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:100616544C>G	uc004axu.2	+	1	1008	c.348C>G	c.(346-348)CGC>CGG	p.R116R		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	116	Fork-head.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)				AGATCCCGCGCGAGGCCGGCC	0.637													8	64					0	0	0	0	G	100616544	G	G	100616544	2	3	128	1	0	0	0	0	0	0	0	1	6037	755	27	3		3	FOXE1	9	100616544	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2374249	100616544	40596887	272	22886											
TRIM14	9830	broad.mit.edu	37	chr9	100872212	100872212	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctatctgggttatgttgtCaatgtgctgctgcttcttga	5	19	10	7	0	4	1	1	1	3	0	4	1	4	1	0	1	3	5	0	1	3	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:100872212C>T	uc004ayd.2	-	2	280	c.262G>A	c.(262-264)GAC>AAC	p.D88N	TRIM14_uc004ayf.1_5'UTR|TRIM14_uc004ayg.1_Missense_Mutation_p.D88N|TRIM14_uc004ayh.1_Missense_Mutation_p.D88N|TRIM14_uc004ayi.1_Missense_Mutation_p.D88N|TRIM14_uc004ayj.1_5'UTR	NM_033220	NP_150089	Q14142	TRI14_HUMAN	tripartite motif protein TRIM14 isoform alpha	88	Potential.					cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GTTATGTTGTCAATGTGCTGC	0.448													25	207					0	0	0	0	T	100872212	T	T	100872212	3	4	128	1	0	0	0	0	1	0	0	0	16556	826	29	2	1086	2	TRIM14	9	100872212	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	255668	100872212	40341219	273	22887											
ERP44	23071	broad.mit.edu	37	chr9	102784444	102784444	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtattctctcttcatcatCatcccattacgaaacaattt	11	16	2	12	1	5	0	3	0	2	0	7	1	6	0	1	0	2	1	1	0	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:102784444C>T	uc004bam.2	-	5	559	c.351G>A	c.(349-351)ATG>ATA	p.M117I	ERP44_uc010msy.2_RNA|ERP44_uc010msz.2_Missense_Mutation_p.M117I	NM_015051	NP_055866	Q9BS26	ERP44_HUMAN	thioredoxin domain containing 4 (endoplasmic	117	Thioredoxin.				cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity				0						TCTTCATCATCATCCCATTAC	0.393													12	115					0	0	0	0	T	102784444	T	T	102784444	3	4	128	1	0	0	0	0	1	0	0	0	5267	826	29	2	901	2	ERP44	9	102784444	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1912232	102784444	38428987	274	22888											
AKNA	80709	broad.mit.edu	37	chr9	117120255	117120255	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctgtggaaggcgctcagaGatgccgcttccctccaggct	6	10	12	13	2	2	1	1	0	1	1	4	3	4	2	3	3	1	3	3	3	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:117120255G>C	uc004biq.3	-	11	2820	c.2685C>G	c.(2683-2685)ATC>ATG	p.I895M	AKNA_uc004bin.3_Missense_Mutation_p.I142M|AKNA_uc004bio.3_Missense_Mutation_p.I355M|AKNA_uc004bip.3_Missense_Mutation_p.I814M|AKNA_uc004bir.3_Missense_Mutation_p.I895M|AKNA_uc004bis.3_Missense_Mutation_p.I895M|AKNA_uc010mve.2_Missense_Mutation_p.I776M	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	895					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						GGCGCTCAGAGATGCCGCTTC	0.642													10	65					0	0	0	0	C	117120255	C	C	117120255	3	2	128	1	0	0	0	0	1	0	0	0	463	932	33	2	1678	2	AKNA	9	117120255	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	14335811	117120255	24093176	275	22889											
OR1L3	26735	broad.mit.edu	37	chr9	125438029	125438029	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagaagggctggcctctgtGatggctccatttgtctgtat	7	13	12	9	0	2	2	0	1	2	1	3	2	3	2	2	3	0	3	2	3	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:125438029G>A	uc011lzb.1	+	1	621	c.621G>A	c.(619-621)GTG>GTA	p.V207V		NM_001005234	NP_001005234	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGGCCTCTGTGATGGCTCCAT	0.453													29	120					0	0	0	0	A	125438029	A	A	125438029	2	1	128	1	0	0	0	0	0	0	0	1	11018	1277	45	2		2	OR1L3	9	125438029	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	8317774	125438029	15775402	276	22890											
RABGAP1	23637	broad.mit.edu	37	chr9	125865491	125865491	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaagggaaagagacttgctGagagcagctgccgcctcccg	10	6	13	12	2	1	2	1	1	0	2	2	5	2	3	3	1	4	3	3	1	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:125865491G>A	uc011lzh.1	+	26	3343	c.3209G>A	c.(3208-3210)TGA>TAA	p.*1070*	RABGAP1_uc004bnl.3_RNA|RABGAP1_uc011lzj.1_Silent_p.*409*	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	1070					cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						GAGACTTGCTGAGAGCAGCTG	0.522											OREG0019466	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	73					0	0	0	0	A	125865491	A	A	125865491	2	1	128	1	0	0	0	0	0	0	0	1	13029	1285	45	2		2	RABGAP1	9	125865491	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	427462	125865491	15347940	277	22891											
HSPA5	3309	broad.mit.edu	37	chr9	127999008	127999008	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagtcttcaatgtcagcatCttggtggctttccagccatt	8	14	9	10	0	4	0	2	0	2	0	5	1	5	0	2	2	2	2	2	2	2	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:127999008C>T	uc004bpn.2	-	8	2084	c.1828G>A	c.(1828-1830)GAT>AAT	p.D610N		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	610					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	ATGTCAGCATCTTGGTGGCTT	0.423										Prostate(1;0.17)			16	127					0	0	0	0	T	127999008	T	T	127999008	3	4	128	1	0	0	0	0	1	0	0	0	7453	913	32	2	140	2	HSPA5	9	127999008	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2133517	127999008	13214423	278	22892											
HSPA5	3309	broad.mit.edu	37	chr9	128001040	128001040	+	Missense_Mutation	SNP	C	T	T																															aagaacaatttcatcaatatCagacttcttcaaatcagaat																										TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:128001040C>T	uc004bpn.2	-	6	1319	c.1063G>A	c.(1063-1065)GAT>AAT	p.D355N		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	355					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	TCATCAATATCAGACTTCTTC	0.418										Prostate(1;0.17)			15	57					0	0	0	0	T	128001040	T	T	128001040	3	4	128	1	0	0	0	0	1	0	0	0	7453	826	29	2	913	2	HSPA5	9	128001040	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2032	128001040	13212391	279	22893	49	2									
HSPA5	3309	broad.mit.edu	37	chr9	128001050	128001050	+	Silent	SNP	C	T	T																															tcatcaatatcagacttcttCaaatcagaatcttccaacac																										TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:128001050C>T	uc004bpn.2	-	6	1309	c.1053G>A	c.(1051-1053)TTG>TTA	p.L351L		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	351					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	CAGACTTCTTCAAATCAGAAT	0.393										Prostate(1;0.17)			16	51					0	0	0	0	T	128001050	T	T	128001050	2	4	128	1	0	0	0	0	0	0	0	1	7453	825	29	2		2	HSPA5	9	128001050	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	10	128001050	13212381	280	22894	49	2									
SPTAN1	6709	broad.mit.edu	37	chr9	131388879	131388879	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagctggaccgccagatcaaGagcttccgcgtagcctccaa	10	6	11	14	3	1	2	1	0	0	2	3	4	3	3	5	1	3	3	5	1	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:131388879G>C	uc004bvl.3	+	48	6587	c.6474G>C	c.(6472-6474)AAG>AAC	p.K2158N	SPTAN1_uc004bvm.3_Missense_Mutation_p.K2163N|SPTAN1_uc004bvn.3_Missense_Mutation_p.K2138N|SPTAN1_uc010mye.1_5'UTR|SPTAN1_uc010myf.1_5'UTR	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2158	Spectrin 22.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GCCAGATCAAGAGCTTCCGCG	0.597													9	32					0	0	0	0	C	131388879	C	C	131388879	3	2	128	1	0	0	0	0	1	0	0	0	15183	933	33	2	6679	2	SPTAN1	9	131388879	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3387829	131388879	9824552	281	22895											
NCS1	23413	broad.mit.edu	37	chr9	132984969	132984969	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggacaatgatggctacatCaccaggaatgagatgctgga	13	9	12	7	0	1	2	1	2	0	1	1	6	1	5	1	4	2	2	1	4	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:132984969C>G	uc004bzi.2	+	5	434	c.348C>G	c.(346-348)ATC>ATG	p.I116M	NCS1_uc010myz.1_Missense_Mutation_p.I98M	NM_014286	NP_055101	P62166	NCS1_HUMAN	frequenin homolog isoform 1	116	EF-hand 3.|2.				negative regulation of calcium ion transport via voltage-gated calcium channel activity|regulation of neuron projection development	cell junction|Golgi cisterna membrane|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|protein binding				0						ATGGCTACATCACCAGGAATG	0.562													11	57					0	0	0	0	G	132984969	G	G	132984969	3	3	128	1	0	0	0	0	1	0	0	0	10294	816	29	2	380	2	NCS1	9	132984969	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1596090	132984969	8228462	282	22896											
RAPGEF1	2889	broad.mit.edu	37	chr9	134473643	134473643	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcaatgagggacagctcGtccacttcctcctccgactg	7	10	10	14	2	1	1	1	1	0	0	6	3	5	2	4	2	1	1	4	2	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:134473643G>A	uc004cbc.2	-	13	2128	c.1998C>T	c.(1996-1998)GAC>GAT	p.D666D	RAPGEF1_uc004cbb.2_Silent_p.D684D|RAPGEF1_uc010mzm.2_RNA|RAPGEF1_uc010mzn.2_Silent_p.D841D|RAPGEF1_uc004cbd.2_Silent_p.D671D|RAPGEF1_uc010mzs.1_Silent_p.D198D|RAPGEF1_uc010mzl.1_Silent_p.D164D|RAPGEF1_uc010mzo.1_3'UTR|RAPGEF1_uc010mzp.1_Silent_p.D143D|RAPGEF1_uc010mzq.1_Silent_p.D250D|RAPGEF1_uc010mzr.1_Silent_p.D251D	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	666					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GGGACAGCTCGTCCACTTCCT	0.592													8	22					0	0	0	0	A	134473643	A	A	134473643	2	1	128	1	0	0	0	0	0	0	0	1	13108	1136	40	1		1	RAPGEF1	9	134473643	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1488674	134473643	6739788	283	22897											
NTNG2	84628	broad.mit.edu	37	chr9	135073644	135073644	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agccctaccagttctacgccGaggactgcatggaggccttc	8	8	11	14	2	1	0	0	0	1	0	2	3	1	2	4	3	4	2	4	3	2	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:135073644G>A	uc004cbh.2	+	3	1281	c.505G>A	c.(505-507)GAG>AAG	p.E169K		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	169	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		GTTCTACGCCGAGGACTGCAT	0.672													6	19					0	0	0	0	A	135073644	A	A	135073644	3	1	128	1	0	0	0	0	1	0	0	0	10759	1059	37	1	511	1	NTNG2	9	135073644	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	600001	135073644	6139787	284	22898											
ADAMTS13	11093	broad.mit.edu	37	chr9	136323096	136323096	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctcgctgagtccagccacGagtaatgcagggggctgccg	7	6	14	14	3	0	1	0	1	0	0	2	2	1	1	4	2	3	4	4	2	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:136323096G>A	uc004cdv.3	+	28	4401	c.3957G>A	c.(3955-3957)ACG>ACA	p.T1319T	ADAMTS13_uc004cdp.3_Intron|ADAMTS13_uc004cdt.1_Silent_p.T1263T|ADAMTS13_uc004cdu.1_Silent_p.T1232T|ADAMTS13_uc004cdw.3_Silent_p.T1263T|ADAMTS13_uc004cdx.3_Silent_p.T1232T|ADAMTS13_uc004cdz.3_Silent_p.T989T|ADAMTS13_uc004cea.1_3'UTR|ADAMTS13_uc004ceb.3_Silent_p.T115T|C9orf7_uc011mdg.1_5'Flank|C9orf7_uc004cec.2_5'Flank|C9orf7_uc011mdh.1_5'Flank|C9orf7_uc011mdi.1_5'Flank|C9orf7_uc010nan.2_5'Flank	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1319	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GTCCAGCCACGAGTAATGCAG	0.607													4	69					0	0	0	0	A	136323096	A	A	136323096	2	1	128	1	0	0	0	0	0	0	0	1	258	1045	37	1		1	ADAMTS13	9	136323096	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1249452	136323096	4890335	285	22899											
VAV2	7410	broad.mit.edu	37	chr9	136629201	136629201	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtcactggatgccctcctCttctacgtacgttgaaggaa	8	11	9	13	3	3	1	1	1	2	0	4	3	4	3	3	2	3	2	3	2	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:136629201C>T	uc004ces.2	-	30	2666	c.2620G>A	c.(2620-2622)GAG>AAG	p.E874K	VAV2_uc004cer.2_Missense_Mutation_p.E835K	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	874	SH3 2.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		ATGCCCTCCTCTTCTACGTAC	0.433													5	42					0	0	0	0	T	136629201	T	T	136629201	3	4	128	1	0	0	0	0	1	0	0	0	17200	922	32	2	20	2	VAV2	9	136629201	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	306105	136629201	4584230	286	22900											
NOTCH1	4851	broad.mit.edu	37	chr9	139391123	139391123	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcatctgggacagggcgctGgcagcaaggctactgtgcag	9	7	15	10	1	2	0	1	0	1	0	2	1	2	1	0	4	3	5	0	4	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:139391123G>A	uc004chz.2	-	34	7068	c.7068C>T	c.(7066-7068)GCC>GCT	p.A2356A		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2356	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACAGGGCGCTGGCAGCAAGGC	0.672			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			10	62					0	0	0	0	A	139391123	A	A	139391123	2	1	128	1	0	0	0	0	0	0	0	1	10601	1335	47	4		4	NOTCH1	9	139391123	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2761922	139391123	1822308	287	22901											
FAM166A	401565	broad.mit.edu	37	chr9	140139845	140139845	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtcccaagtctctggagtCtcccttcctgcctggtgggc	3	12	12	14	0	2	0	0	0	2	0	6	1	4	1	4	3	1	0	4	3	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:140139845C>T	uc004cmi.1	-	3	491	c.436G>A	c.(436-438)GAC>AAC	p.D146N		NM_001001710	NP_001001710	Q6J272	F166A_HUMAN	hypothetical protein LOC401565	146										ovary(1)	1						TCTCTGGAGTCTCCCTTCCTG	0.652													7	74					0	0	0	0	T	140139845	T	T	140139845	3	4	128	1	0	0	0	0	1	0	0	0	5509	913	32	2	537	2	FAM166A	9	140139845	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	748722	140139845	1073586	288	22902											
COBRA1	25920	broad.mit.edu	37	chr9	140150496	140150496	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctggagcgagtgtcagccatCgcttcggaggggaaggctga	8	7	17	9	3	1	1	1	1	0	0	3	5	1	4	1	5	2	2	1	5	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:140150496C>G	uc004cmm.3	+	2	443	c.240C>G	c.(238-240)ATC>ATG	p.I80M		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	80					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		TGTCAGCCATCGCTTCGGAGG	0.642													14	81					0	0	0	0	G	140150496	G	G	140150496	3	3	128	1	0	0	0	0	1	0	0	0	3670	874	31	3	246	3	COBRA1	9	140150496	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	10651	140150496	1062935	289	22903											
ITIH2	3698	broad.mit.edu	37	chr10	7759731	7759731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatctatctgcaacctggaCggctggccaaacacttagag	11	8	11	11	1	2	1	0	0	2	1	2	3	2	3	2	4	3	2	2	4	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:7759731C>T	uc001ijs.2	+	6	772	c.610C>T	c.(610-612)CGG>TGG	p.R204W		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	204					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						GCAACCTGGACGGCTGGCCAA	0.512													24	135					0	0	0	0	T	7759731	T	T	7759731	3	4	128	1	0	0	0	0	1	0	0	0	7943	527	19	1	632	1	ITIH2	10	7759731	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08		7759731	127775016	290	22904											
C10orf111	221060	broad.mit.edu	37	chr10	15138708	15138708	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcaactcttactgcctttCtcttttcgggctcaagattc	7	15	7	12	1	3	1	1	0	2	1	6	1	3	1	1	2	3	2	1	2	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:15138708C>T	uc001inw.2	-	2	390	c.116G>A	c.(115-117)AGA>AAA	p.R39K	RPP38_uc001iny.3_5'Flank|RPP38_uc009xjm.2_5'Flank|RPP38_uc001inx.3_5'Flank	NM_153244	NP_694976	Q8N326	CJ111_HUMAN	hypothetical protein LOC221060	39						integral to membrane					0						TACTGCCTTTCTCTTTTCGGG	0.498													33	112					0	0	0	0	T	15138708	T	T	15138708	3	4	128	1	0	0	0	0	1	0	0	0	1589	913	32	2	355	2	C10orf111	10	15138708	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	7378977	15138708	120396039	291	22905											
VIM	7431	broad.mit.edu	37	chr10	17275592	17275592	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgttcaaaataggatgttGacaatgcgtctctggcacgt	10	13	10	8	2	3	1	1	1	2	0	4	2	3	2	0	2	1	3	0	2	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:17275592G>C	uc001iou.2	+	4	1044	c.631G>C	c.(631-633)GAC>CAC	p.D211H	VIM_uc001iov.1_Missense_Mutation_p.D211H|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Missense_Mutation_p.D211H|VIM_uc001ioy.1_Missense_Mutation_p.D211H|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Missense_Mutation_p.D211H|VIM_uc001ipc.1_Missense_Mutation_p.D211H	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	211	Rod.|Coil 1B.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						ATAGGATGTTGACAATGCGTC	0.403													7	37					0	0	0	0	C	17275592	C	C	17275592	3	2	128	1	0	0	0	0	1	0	0	0	17234	1290	45	2	641	2	VIM	10	17275592	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2136884	17275592	118259155	292	22906											
SLC39A12	221074	broad.mit.edu	37	chr10	18250518	18250518	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttcttccacagtgctttgaAccagatgcactattactaat	11	15	5	10	0	1	2	0	1	1	1	2	2	2	2	2	0	4	2	2	0	4	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:18250518A>T	uc001ipo.2	+	3	543	c.270A>T	c.(268-270)GAA>GAT	p.E90D	SLC39A12_uc001ipn.2_Missense_Mutation_p.E90D|SLC39A12_uc001ipp.2_Missense_Mutation_p.E90D|SLC39A12_uc010qck.1_5'UTR	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	90	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						AGTGCTTTGAACCAGATGCAC	0.368													11	65					0	0	0	0	T	18250518	T	T	18250518	3	4	128	1	0	0	0	0	1	0	0	0	14679	40	2	5	276	5	SLC39A12	10	18250518	Missense_Mutation	SNP	A	TCGA-CR-6481-01A-11D-1870-08	974926	18250518	117284229	293	22907											
DNAJC1	64215	broad.mit.edu	37	chr10	22209807	22209807	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacaagagtaatgccagctCagcattgctcatttttctca	12	12	7	10	0	3	1	3	0	1	1	4	2	3	1	1	0	5	4	1	0	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:22209807C>A	uc001irc.2	-	4	744	c.457G>T	c.(457-459)GAG>TAG	p.E153*	DNAJC1_uc001ird.2_Nonsense_Mutation_p.E39*	NM_022365	NP_071760	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	153	Lumenal (By similarity).				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			lung(1)	1		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				AATGCCAGCTCAGCATTGCTC	0.398													12	63					0.000978159	0.00100242	1	0	A	22209807	A	A	22209807	4	1	128	1	0	0	0	0	0	1	0	0	4650	835	29	2	1243	2	DNAJC1	10	22209807	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3959289	22209807	113324940	294	22908											
ANKRD26	22852	broad.mit.edu	37	chr10	27306526	27306526	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtttgacttgaccaagttCtaccatattcctttctatat	9	18	4	10	0	2	2	0	2	2	0	3	2	3	2	3	0	1	2	3	0	5	9			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:27306526C>G	uc001ith.2	-	30	4580	c.4408G>C	c.(4408-4410)GAA>CAA	p.E1470Q	ANKRD26_uc001itg.2_Missense_Mutation_p.E1157Q|ANKRD26_uc009xku.1_Missense_Mutation_p.E1471Q	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1470	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TGACCAAGTTCTACCATATTC	0.318													19	85					0	0	0	0	G	27306526	G	G	27306526	3	3	128	1	0	0	0	0	1	0	0	0	654	922	32	2	741	2	ANKRD26	10	27306526	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5096719	27306526	108228221	295	22909											
FZD8	8325	broad.mit.edu	37	chr10	35929113	35929113	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccatgtgagcgacaagatCacccaccagatggagctggc	13	5	11	12	1	1	3	1	1	0	2	1	5	1	4	3	2	3	1	3	2	2	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:35929113C>T	uc001iyz.1	-	1	1250	c.1245G>A	c.(1243-1245)GTG>GTA	p.V415V		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	415	Helical; Name=3; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						GCGACAAGATCACCCACCAGA	0.632													10	38					0	0	0	0	T	35929113	T	T	35929113	2	4	128	1	0	0	0	0	0	0	0	1	6170	813	29	2		2	FZD8	10	35929113	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	8622587	35929113	99605634	296	22910											
ZNF33A	7581	broad.mit.edu	37	chr10	38344019	38344019	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtcacaccttcagaaaggtGataaaggagagaaacacttt	16	9	9	7	0	2	3	2	1	0	2	2	5	2	4	1	2	1	0	1	2	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:38344019G>A	uc001izh.2	+	5	1142	c.964G>A	c.(964-966)GAT>AAT	p.D322N	ZNF33A_uc001izg.2_Missense_Mutation_p.D323N|ZNF33A_uc010qev.1_Missense_Mutation_p.D329N|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	322						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						TCAGAAAGGTGATAAAGGAGA	0.423													14	85					0	0	0	0	A	38344019	A	A	38344019	3	1	128	1	0	0	0	0	1	0	0	0	17921	1290	45	2	981	2	ZNF33A	10	38344019	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2414906	38344019	97190728	297	22911											
ANK3	288	broad.mit.edu	37	chr10	61840377	61840377	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtctatctgttttctcaatCtgaaaaggaaaaaaaaaaag	18	11	6	6	1	4	1	1	1	4	0	5	2	4	2	0	1	0	1	0	1	9	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:61840377C>T	uc001jky.2	-	36	4543	c.4351_splice	c.e36-1	p.I1451_splice	ANK3_uc001jkw.2_Splice_Site_p.I576_splice|ANK3_uc009xpa.2_Splice_Site_p.I576_splice|ANK3_uc001jkx.2_Splice_Site_p.I620_splice|ANK3_uc010qih.1_Splice_Site_p.I1443_splice|ANK3_uc001jkz.3_Splice_Site_p.I1436_splice|ANK3_uc001jla.1_Intron|ANK3_uc001jkv.2_Splice_Site|ANK3_uc009xpb.1_5'Flank|ANK3_uc009xpc.1_5'Flank	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTTTCTCAATCTGAAAAGGAA	0.378													6	37					0	0	0	0	T	61840377	T	T	61840377	5	4	128	1	0	0	0	0	0	0	1	0	622	927	32	2	9128	2	ANK3	10	61840377	Splice_Site	SNP	C	TCGA-CR-6481-01A-11D-1870-08	23496358	61840377	73694370	298	22912											
PRF1	5551	broad.mit.edu	37	chr10	72358020	72358020	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcatcgtccctgccagagTcctgatcccagacctgcaac	8	8	9	16	1	1	3	1	1	0	2	5	3	4	3	5	1	3	1	5	1	1	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:72358020T>A	uc009xqg.2	-	3	1618	c.1457A>T	c.(1456-1458)GAC>GTC	p.D486V	PRF1_uc001jrf.3_Missense_Mutation_p.D486V	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	486	C2.	Calcium 2; via carbonyl oxygen (By similarity).			apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CCTGCCAGAGTCCTGATCCCA	0.572			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				21	72					0	0	0	0	A	72358020	A	A	72358020	3	1	128	1	0	0	0	0	1	0	0	0	12540	1667	58	5	214	5	PRF1	10	72358020	Missense_Mutation	SNP	T	TCGA-CR-6481-01A-11D-1870-08	10517643	72358020	63176727	299	22913											
POLR3A	11128	broad.mit.edu	37	chr10	79784393	79784393	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaaatttgatacaatgggatCcaccacttttttgttggtct	10	16	8	7	0	1	1	0	1	1	0	2	3	2	2	2	2	1	1	2	2	3	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:79784393C>T	uc001jzn.2	-	5	653	c.559G>A	c.(559-561)GAT>AAT	p.D187N		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	187					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			ACAATGGGATCCACCACTTTT	0.383													13	66					0	0	0	0	T	79784393	T	T	79784393	3	4	128	1	0	0	0	0	1	0	0	0	12283	855	30	2	3721	2	POLR3A	10	79784393	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	7426373	79784393	55750354	300	22914											
LRIT1	26103	broad.mit.edu	37	chr10	85994045	85994045	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcacatctcagttcagtctCaatgaaggccaagtttgggg	10	10	12	9	0	3	1	3	1	2	0	5	1	3	1	1	4	0	3	1	4	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:85994045C>T	uc001kcz.1	-	3	701	c.679G>A	c.(679-681)GAG>AAG	p.E227K		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	227	LRRCT.|Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						AGTTCAGTCTCAATGAAGGCC	0.582													13	66					0	0	0	0	T	85994045	T	T	85994045	3	4	128	1	0	0	0	0	1	0	0	0	8997	835	29	2	1200	2	LRIT1	10	85994045	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	6209652	85994045	49540702	301	22915											
TMEM20	159371	broad.mit.edu	37	chr10	95660597	95660597	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatgatgcttatatactatGcttaccagacaatgtccctc	11	13	5	12	0	0	2	0	1	0	1	2	2	1	2	3	0	4	2	3	0	6	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:95660597G>A	uc001kjg.1	+	3	509	c.448G>A	c.(448-450)GCT>ACT	p.A150T	TMEM20_uc001kji.2_Intron|TMEM20_uc001kjf.1_Missense_Mutation_p.A149T|TMEM20_uc001kjh.2_Intron|TMEM20_uc010qnw.1_Missense_Mutation_p.A133T|TMEM20_uc001kjj.2_Intron	NM_001134658	NP_001128130	Q2M3R5	TMM20_HUMAN	transmembrane protein 20 isoform 1	150	DUF6 1.|Helical; (Potential).					integral to membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;3.46e-05)|Renal(717;0.018)|Ovarian(717;0.0228)|all_hematologic(284;0.189)		STAD - Stomach adenocarcinoma(243;0.00345)		TATATACTATGCTTACCAGAC	0.413													15	69					0	0	0	0	A	95660597	A	A	95660597	3	1	128	1	0	0	0	0	1	0	0	0	16188	1319	46	4	458	4	TMEM20	10	95660597	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	9666552	95660597	39874150	302	22916											
ALDH18A1	5832	broad.mit.edu	37	chr10	97373783	97373783	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atacatgtgacagatcccttCgctgtgccccatcactggaa	10	10	8	13	1	1	2	1	1	0	1	3	3	2	3	3	1	2	1	3	1	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:97373783C>T	uc001kkz.2	-	14	1983	c.1741G>A	c.(1741-1743)GAA>AAA	p.E581K	ALDH18A1_uc001kky.2_Missense_Mutation_p.E579K|ALDH18A1_uc010qog.1_Missense_Mutation_p.E470K|ALDH18A1_uc010qoh.1_Missense_Mutation_p.E369K	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	581	Gamma-glutamyl phosphate reductase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	CAGATCCCTTCGCTGTGCCCC	0.502													7	179					0	0	0	0	T	97373783	T	T	97373783	3	4	128	1	0	0	0	0	1	0	0	0	489	893	31	1	666	1	ALDH18A1	10	97373783	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1713186	97373783	38160964	303	22917											
TLL2	7093	broad.mit.edu	37	chr10	98133495	98133495	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatgggggccaggctgtcCggcccgtcatacatttccag	8	8	13	12	2	1	1	1	0	0	1	3	1	3	1	4	4	1	1	4	4	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:98133495C>T	uc001kml.1	-	19	2746	c.2520G>A	c.(2518-2520)CCG>CCA	p.P840P		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	840	CUB 4.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CCAGGCTGTCCGGCCCGTCAT	0.542													11	61					0	0	0	0	T	98133495	T	T	98133495	2	4	128	1	0	0	0	0	0	0	0	1	16012	639	23	1		1	TLL2	10	98133495	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	759712	98133495	37401252	304	22918											
TLX1	3195	broad.mit.edu	37	chr10	102891411	102891411	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggctgcatgggacccgcctCgcgcctccaggacggagaat	7	6	14	14	4	0	1	0	0	0	1	2	4	1	3	4	4	1	2	4	4	1	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:102891411C>T	uc001ksw.2	+	1	351	c.113C>T	c.(112-114)TCG>TTG	p.S38L	TLX1NB_uc001ksv.2_5'Flank	NM_005521	NP_005512	P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	38						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GGACCCGCCTCGCGCCTCCAG	0.706			T	TRB@|TRD@	T-ALL								4	16					0	0	0	0	T	102891411	T	T	102891411	3	4	128	1	0	0	0	0	1	0	0	0	16025	893	31	1	115	1	TLX1	10	102891411	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	4757916	102891411	32643336	305	22919											
PDCD11	22984	broad.mit.edu	37	chr10	105194617	105194617	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtgaaggtgactcccaacGaggggctgaccgtctccttc	7	9	13	12	2	1	3	0	3	1	0	4	4	2	3	3	4	1	1	3	4	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:105194617G>A	uc001kwy.1	+	25	3817	c.3730G>A	c.(3730-3732)GAG>AAG	p.E1244K		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1244	S1 motif 11.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GACTCCCAACGAGGGGCTGAC	0.547													10	39					0	0	0	0	A	105194617	A	A	105194617	3	1	128	1	0	0	0	0	1	0	0	0	11671	1059	37	1	3824	1	PDCD11	10	105194617	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2303206	105194617	30340130	306	22920											
COL17A1	1308	broad.mit.edu	37	chr10	105819884	105819884	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggatctgacgcacttgcagcGatgctggcaggggaggctgt	7	8	17	9	2	1	1	0	1	1	0	1	4	1	3	0	5	3	5	0	5	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:105819884G>A	uc001kxr.2	-	14	1303	c.1134C>T	c.(1132-1134)ATC>ATT	p.I378I	COL17A1_uc010qqv.1_Silent_p.I362I	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	378	Cytoplasmic (Potential).|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CACTTGCAGCGATGCTGGCAG	0.517													9	67					0	0	0	0	A	105819884	A	A	105819884	2	1	128	1	0	0	0	0	0	0	0	1	3689	1048	37	1		1	COL17A1	10	105819884	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	625267	105819884	29714863	307	22921											
ABLIM1	3983	broad.mit.edu	37	chr10	116213165	116213165	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggaaatgtttaggggcctGagcgtaagttggagttagag	11	11	16	3	1	0	2	0	1	0	1	0	4	0	4	1	4	1	4	1	4	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:116213165G>A	uc010qsg.1	-	13	1618	c.1519C>T	c.(1519-1521)CAG>TAG	p.Q507*	ABLIM1_uc010qsh.1_Nonsense_Mutation_p.Q475*|ABLIM1_uc010qsi.1_Nonsense_Mutation_p.Q447*|ABLIM1_uc010qsk.1_Nonsense_Mutation_p.Q431*|ABLIM1_uc009xyp.2_Nonsense_Mutation_p.Q469*|ABLIM1_uc010qsf.1_Intron|ABLIM1_uc009xyn.2_Intron|ABLIM1_uc010qsj.1_Intron|ABLIM1_uc009xyo.2_Intron	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	507					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		TTAGGGGCCTGAGCGTAAGTT	0.532													6	54					0	0	0	0	A	116213165	A	A	116213165	4	1	128	1	0	0	0	0	0	1	0	0	94	1299	45	2	857	2	ABLIM1	10	116213165	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	10393281	116213165	19321582	308	22922											
ATRNL1	26033	broad.mit.edu	37	chr10	117059722	117059722	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaagctaatccttgtacatCtatggcaaatggccttgtct	12	13	7	9	0	2	0	0	0	2	0	3	0	3	0	2	2	2	3	2	2	6	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:117059722C>T	uc001lcg.2	+	16	2980	c.2594C>T	c.(2593-2595)TCT>TTT	p.S865F	ATRNL1_uc010qsm.1_Missense_Mutation_p.S40F|ATRNL1_uc010qsn.1_5'Flank	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	865	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CCTTGTACATCTATGGCAAAT	0.433													11	33					0	0	0	0	T	117059722	T	T	117059722	3	4	128	1	0	0	0	0	1	0	0	0	1209	913	32	2	2656	2	ATRNL1	10	117059722	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	846557	117059722	18475025	309	22923											
EIF3A	8661	broad.mit.edu	37	chr10	120801689	120801689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctccaaggtcctcgatcatCatccaaccctcgcctgggac	8	8	7	18	2	2	0	2	0	0	0	7	2	5	1	6	2	1	0	6	2	2	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:120801689C>T	uc001ldu.2	-	19	3489	c.3343G>A	c.(3343-3345)GAT>AAT	p.D1115N	EIF3A_uc010qsu.1_Missense_Mutation_p.D1081N|EIF3A_uc009xzg.1_Missense_Mutation_p.D154N	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	1115	20.|Asp-rich.|25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CCTCGATCATCATCCAACCCT	0.602													25	131					0	0	0	0	T	120801689	T	T	120801689	3	4	128	1	0	0	0	0	1	0	0	0	5034	826	29	2	821	2	EIF3A	10	120801689	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3741967	120801689	14733058	310	22924											
TACC2	10579	broad.mit.edu	37	chr10	123844325	123844325	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gggccggcgtgtgatgcgtcGagacaggaatttcatgctgg	7	9	17	8	4	1	2	1	1	0	1	2	4	1	3	1	4	2	1	1	4	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:123844325G>C	uc001lfv.2	+	4	2670	c.2310G>C	c.(2308-2310)TCG>TCC	p.S770S	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.S770S|TACC2_uc010qtv.1_Silent_p.S770S	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	770						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GTGATGCGTCGAGACAGGAAT	0.607													16	79					0	0	0	0	C	123844325	C	C	123844325	2	2	128	1	0	0	0	0	0	0	0	1	15568	1045	37	3		3	TACC2	10	123844325	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3042636	123844325	11690422	311	22925											
PHRF1	57661	broad.mit.edu	37	chr11	587351	587351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggctctttcaattctgatGatgatgcagagagctgccca	9	12	10	10	0	3	4	1	3	2	1	3	5	3	4	1	1	3	3	1	1	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:587351G>A	uc001lqe.2	+	4	438	c.307G>A	c.(307-309)GAT>AAT	p.D103N	PHRF1_uc010qwc.1_Missense_Mutation_p.D103N|PHRF1_uc010qwd.1_Missense_Mutation_p.D102N|PHRF1_uc010qwe.1_Missense_Mutation_p.D99N	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	103							RNA polymerase binding|zinc ion binding				0						CAATTCTGATGATGATGCAGA	0.557													10	36					0	0	0	0	A	587351	A	A	587351	3	1	128	1	0	0	0	0	1	0	0	0	11916	1290	45	2	317	2	PHRF1	11	587351	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08		587351	134419165	312	22926											
PHRF1	57661	broad.mit.edu	37	chr11	587453	587453	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctgcctggactgcattgtcGaatggtccaaggtgagttca	8	12	12	9	1	2	1	1	1	1	0	4	3	3	2	2	3	2	2	2	3	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:587453G>A	uc001lqe.2	+	4	540	c.409G>A	c.(409-411)GAA>AAA	p.E137K	PHRF1_uc010qwc.1_Missense_Mutation_p.E137K|PHRF1_uc010qwd.1_Missense_Mutation_p.E136K|PHRF1_uc010qwe.1_Missense_Mutation_p.E133K	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	137	RING-type; degenerate.						RNA polymerase binding|zinc ion binding				0						CTGCATTGTCGAATGGTCCAA	0.562													9	54					0	0	0	0	A	587453	A	A	587453	3	1	128	1	0	0	0	0	1	0	0	0	11916	1059	37	1	419	1	PHRF1	11	587453	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	102	587453	134419063	313	22927											
LRDD	55367	broad.mit.edu	37	chr11	801315	801315	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagggggctcactgcagcCtctggttctcccaggagggc	6	7	15	13	0	3	0	1	0	2	0	4	1	3	1	2	5	3	4	2	5	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:801315C>G	uc001lro.1	-	9	1675	c.1533G>C	c.(1531-1533)GAG>GAC	p.E511D	LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.E511D|LRDD_uc001lrl.1_Missense_Mutation_p.E365D|LRDD_uc001lrm.1_Missense_Mutation_p.E198D|LRDD_uc001lrn.1_Missense_Mutation_p.E365D|LRDD_uc001lrp.1_Missense_Mutation_p.E149D	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	511	ZU5 2.				apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCACTGCAGCCTCTGGTTCTC	0.697													5	14					0	0	0	0	G	801315	G	G	801315	3	3	128	1	0	0	0	0	1	0	0	0	8986	680	24	4	1231	4	LRDD	11	801315	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	213862	801315	134205201	314	22928											
TRPM5	29850	broad.mit.edu	37	chr11	2433448	2433448	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccacatacagtgtgaacttCttcaccaggtgtgtgtcctc	8	12	8	13	0	2	1	1	1	1	0	4	1	3	1	3	1	2	0	3	1	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:2433448C>T	uc001lwm.3	-	16	2400	c.2391G>A	c.(2389-2391)AAG>AAA	p.K797K	TRPM5_uc010qxl.1_Silent_p.K797K|TRPM5_uc009ydn.2_Silent_p.K799K	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	797	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTGTGAACTTCTTCACCAGGT	0.597													29	104					0	0	0	0	T	2433448	T	T	2433448	2	4	128	1	0	0	0	0	0	0	0	1	16656	912	32	2		2	TRPM5	11	2433448	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1632133	2433448	132573068	315	22929											
RPS13	6207	broad.mit.edu	37	chr11	17098993	17098993	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tacagtggggacgctgcgtcGatagggtaaagccgactggg	9	7	17	8	4	0	0	0	0	0	0	1	3	0	1	1	4	3	2	1	4	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:17098993G>C	uc001mmp.2	-	2	87	c.55C>G	c.(55-57)CGA>GGA	p.R19G		NM_001017	NP_001008	P62277	RS13_HUMAN	ribosomal protein S13	19					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA binding|protein binding|structural constituent of ribosome				0						ACGCTGCGTCGATAGGGTAAA	0.632													6	22					0	0	0	0	C	17098993	C	C	17098993	3	2	128	1	0	0	0	0	1	0	0	0	13688	1066	37	3	420	3	RPS13	11	17098993	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	14665545	17098993	117907523	316	22930											
AMBRA1	55626	broad.mit.edu	37	chr11	46564069	46564069	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagcgtctcaggtcacactGaagctcatggcgaatgctgc	10	8	12	11	2	3	1	3	1	1	0	4	3	3	1	0	2	4	2	0	2	3	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:46564069G>A	uc010rgu.1	-	7	1858	c.1498C>T	c.(1498-1500)CAG>TAG	p.Q500*	AMBRA1_uc010rgt.1_Nonsense_Mutation_p.Q66*|AMBRA1_uc009ylc.1_Nonsense_Mutation_p.Q500*|AMBRA1_uc001ncu.1_Nonsense_Mutation_p.Q410*|AMBRA1_uc001ncv.2_Nonsense_Mutation_p.Q410*|AMBRA1_uc001ncw.2_Nonsense_Mutation_p.Q410*|AMBRA1_uc001ncx.2_Nonsense_Mutation_p.Q500*	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	500					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		AGGTCACACTGAAGCTCATGG	0.567													15	67					0	0	0	0	A	46564069	A	A	46564069	4	1	128	1	0	0	0	0	0	1	0	0	565	1299	45	2	2446	2	AMBRA1	11	46564069	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	29465076	46564069	88442447	317	22931											
AMBRA1	55626	broad.mit.edu	37	chr11	46564092	46564092	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gctcatggcgaatgctgcccGagttgttttggctggagcca	6	11	14	10	2	1	0	1	0	0	0	1	3	1	1	2	3	3	5	2	3	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:46564092G>C	uc010rgu.1	-	7	1835	c.1475C>G	c.(1474-1476)TCG>TGG	p.S492W	AMBRA1_uc010rgt.1_Missense_Mutation_p.S58W|AMBRA1_uc009ylc.1_Missense_Mutation_p.S492W|AMBRA1_uc001ncu.1_Missense_Mutation_p.S402W|AMBRA1_uc001ncv.2_Missense_Mutation_p.S402W|AMBRA1_uc001ncw.2_Missense_Mutation_p.S402W|AMBRA1_uc001ncx.2_Missense_Mutation_p.S492W	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	492					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		AATGCTGCCCGAGTTGTTTTG	0.562													15	72					0	0	0	0	C	46564092	C	C	46564092	3	2	128	1	0	0	0	0	1	0	0	0	565	1059	37	3	2469	3	AMBRA1	11	46564092	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	23	46564092	88442424	318	22932											
GIF	2694	broad.mit.edu	37	chr11	59604756	59604756	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcccctgcttaatctcattGagtatcatatccgtagtctt	8	17	5	11	1	3	1	2	1	2	0	6	1	5	1	3	0	1	3	3	0	4	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:59604756G>C	uc001noi.2	-	6	810	c.762C>G	c.(760-762)CTC>CTG	p.L254L		NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	254					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						TAATCTCATTGAGTATCATAT	0.463													13	53					0	0	0	0	C	59604756	C	C	59604756	2	2	128	1	0	0	0	0	0	0	0	1	6413	1277	45	2		2	GIF	11	59604756	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	13040664	59604756	75401760	319	22933											
MS4A6E	245802	broad.mit.edu	37	chr11	60107353	60107353	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcagggaactctgtctctGatgctggtttctactgtgtt	5	18	10	8	0	4	1	1	1	3	0	5	2	4	2	0	2	3	3	0	2	2	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:60107353G>C	uc001npd.2	+	3	383	c.369G>C	c.(367-369)CTG>CTC	p.L123L		NM_139249	NP_640342	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member	123	Helical; (Potential).					integral to membrane	receptor activity				0						CTCTGTCTCTGATGCTGGTTT	0.483													27	173					0	0	0	0	C	60107353	C	C	60107353	2	2	128	1	0	0	0	0	0	0	0	1	9918	1277	45	2		2	MS4A6E	11	60107353	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	502597	60107353	74899163	320	22934											
SLC25A45	283130	broad.mit.edu	37	chr11	65147398	65147398	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccggtaggtggtctgggtCtgcagcctcacctgggtggg	3	9	17	12	1	3	0	1	0	2	0	3	0	3	0	4	6	2	2	4	6	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:65147398C>G	uc001odp.1	-	3	515	c.93G>C	c.(91-93)CAG>CAC	p.Q31H	SLC25A45_uc009yqi.1_Missense_Mutation_p.Q31H|SLC25A45_uc001odq.1_Intron|SLC25A45_uc001odr.1_Missense_Mutation_p.Q31H|SLC25A45_uc001ods.1_5'UTR|SLC25A45_uc001odt.1_5'UTR	NM_001077241	NP_001070709	Q8N413	S2545_HUMAN	solute carrier family 25, member 45 isoform b	31	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						TGGTCTGGGTCTGCAGCCTCA	0.632													6	38					0	0	0	0	G	65147398	G	G	65147398	3	3	128	1	0	0	0	0	1	0	0	0	14574	912	32	2	789	2	SLC25A45	11	65147398	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5040045	65147398	69859118	321	22935											
CTSW	1521	broad.mit.edu	37	chr11	65649791	65649791	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccagcgccatctcacccatCaaggaccaggtatctgccgc	9	6	9	17	2	3	0	2	0	2	0	4	1	3	1	5	2	2	1	5	2	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:65649791C>T	uc001ogc.1	+	4	474	c.432C>T	c.(430-432)ATC>ATT	p.I144I	CTSW_uc001ogb.1_Silent_p.I144I	NM_001335	NP_001326	P56202	CATW_HUMAN	cathepsin W preproprotein	144					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.168)		TCTCACCCATCAAGGACCAGG	0.612													10	45					0	0	0	0	T	65649791	T	T	65649791	2	4	128	1	0	0	0	0	0	0	0	1	4059	816	29	2		2	CTSW	11	65649791	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	502393	65649791	69356725	322	22936											
CTSW	1521	broad.mit.edu	37	chr11	65650706	65650706	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctataccggaaaggtgtgatCaaggccacacccaccacctg	12	6	9	14	1	1	1	1	1	0	0	1	2	1	2	5	3	1	0	5	3	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:65650706C>G	uc001ogc.1	+	9	873	c.831C>G	c.(829-831)ATC>ATG	p.I277M	CTSW_uc001ogb.1_Missense_Mutation_p.I277M	NM_001335	NP_001326	P56202	CATW_HUMAN	cathepsin W preproprotein	277					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.168)		AAGGTGTGATCAAGGCCACAC	0.617													17	71					0	0	0	0	G	65650706	G	G	65650706	3	3	128	1	0	0	0	0	1	0	0	0	4059	816	29	2	865	2	CTSW	11	65650706	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	915	65650706	69355810	323	22937											
GPR152	390212	broad.mit.edu	37	chr11	67220094	67220094	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagcagggccaccaggaaGaccgtgtcccagccaccttg	10	4	12	15	1	0	1	0	0	0	1	1	2	1	2	6	2	3	2	6	2	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:67220094G>A	uc001olm.2	-	1	107	c.102C>T	c.(100-102)GTC>GTT	p.V34V	uc009yrw.1_RNA|CABP4_uc001oln.2_5'UTR|CABP4_uc001olo.2_5'Flank	NM_206997	NP_996880	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	34	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CCACCAGGAAGACCGTGTCCC	0.667													6	14					0	0	0	0	A	67220094	A	A	67220094	2	1	128	1	0	0	0	0	0	0	0	1	6696	929	33	2		2	GPR152	11	67220094	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1569388	67220094	67786422	324	22938											
TBX10	347853	broad.mit.edu	37	chr11	67399081	67399081	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagggcttctggcatcactGggagtcctggccaggcccca	6	7	13	15	0	2	0	1	0	1	0	3	1	3	1	5	5	0	2	5	5	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:67399081G>A	uc001omp.2	-	8	1241	c.1153C>T	c.(1153-1155)CAG>TAG	p.Q385*	NUDT8_uc001omn.2_5'Flank|NUDT8_uc001omo.1_5'Flank	NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	385					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TGGCATCACTGGGAGTCCTGG	0.672													4	9					0	0	0	0	A	67399081	A	A	67399081	4	1	128	1	0	0	0	0	0	1	0	0	15717	1357	47	4	8	4	TBX10	11	67399081	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	178987	67399081	67607435	325	22939											
DNAJB13	374407	broad.mit.edu	37	chr11	73675980	73675980	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctttggggggctccagggccGaggggtcaagaagcaggacc	8	5	18	10	1	1	1	1	0	0	1	2	3	2	2	3	7	1	2	3	7	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:73675980G>C	uc001ouo.2	+	4	1143	c.392G>C	c.(391-393)CGA>CCA	p.R131P		NM_153614	NP_705842	P59910	DJB13_HUMAN	testis spermatogenesis apoptosis-related protein	131					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding				0	Breast(11;7.42e-05)					CTCCAGGGCCGAGGGGTCAAG	0.498											OREG0021218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	61					0	0	0	0	C	73675980	C	C	73675980	3	2	128	1	0	0	0	0	1	0	0	0	4640	1058	37	3	406	3	DNAJB13	11	73675980	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	6276899	73675980	61330536	326	22940											
ME3	10873	broad.mit.edu	37	chr11	86153891	86153891	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caattctcaaagacacgtctCggatggtgctgagtggtggg	9	10	14	8	2	2	2	1	1	2	1	4	3	2	3	0	4	1	1	0	4	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:86153891C>T	uc001pbz.2	-	13	1879	c.1625G>A	c.(1624-1626)CGA>CAA	p.R542Q	ME3_uc001pca.2_Missense_Mutation_p.R542Q|ME3_uc009yvk.2_Missense_Mutation_p.R542Q	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	542					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	AGACACGTCTCGGATGGTGCT	0.517													12	68					0	0	0	0	T	86153891	T	T	86153891	3	4	128	1	0	0	0	0	1	0	0	0	9472	884	31	1	197	1	ME3	11	86153891	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	12477911	86153891	48852625	327	22941											
CNTN5	53942	broad.mit.edu	37	chr11	100061931	100061931	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgagggaaagtacgtttgcCgaggggaaaacgtctttggt	11	9	15	6	4	1	0	0	0	1	0	1	4	1	2	1	4	3	2	1	4	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:100061931C>T	uc001pga.2	+	14	1993	c.1654C>T	c.(1654-1656)CGA>TGA	p.R552*	CNTN5_uc009ywv.1_Nonsense_Mutation_p.R552*|CNTN5_uc001pfz.2_Nonsense_Mutation_p.R552*|CNTN5_uc001pgb.2_Nonsense_Mutation_p.R478*|CNTN5_uc010ruk.1_5'UTR	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	552	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GTACGTTTGCCGAGGGGAAAA	0.393													10	36					0	0	0	0	T	100061931	T	T	100061931	4	4	128	1	0	0	0	0	0	1	0	0	3659	644	23	1	1700	1	CNTN5	11	100061931	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	13908040	100061931	34944585	328	22942											
ATM	472	broad.mit.edu	37	chr11	108106437	108106437	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagaactcttaaattatatCatggatacagtgaaagattc	17	12	6	6	0	2	3	1	1	1	2	3	4	2	4	0	1	2	0	0	1	8	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:108106437C>T	uc001pkb.1	+	5	757	c.372C>T	c.(370-372)ATC>ATT	p.I124I	ATM_uc009yxr.1_Silent_p.I124I	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	124					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TAAATTATATCATGGATACAG	0.313			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			15	42					0	0	0	0	T	108106437	T	T	108106437	2	4	128	1	0	0	0	0	0	0	0	1	1111	816	29	2		2	ATM	11	108106437	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	8044506	108106437	26900079	329	22943											
PPP2R1B	5519	broad.mit.edu	37	chr11	111636039	111636039	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtaagaaatggcaacaattCacttcgggtcctttctactc	11	13	7	10	1	2	1	1	0	1	1	5	1	3	1	1	2	2	2	1	2	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:111636039C>T	uc001plx.1	-	2	268	c.184G>A	c.(184-186)GAA>AAA	p.E62K	PPP2R1B_uc001plw.1_Missense_Mutation_p.E62K|PPP2R1B_uc010rwi.1_Intron|PPP2R1B_uc010rwj.1_5'UTR|PPP2R1B_uc010rwk.1_Missense_Mutation_p.E62K|PPP2R1B_uc010rwl.1_Missense_Mutation_p.E62K	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	62	HEAT 2.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		GGCAACAATTCACTTCGGGTC	0.363													12	81					0	0	0	0	T	111636039	T	T	111636039	3	4	128	1	0	0	0	0	1	0	0	0	12443	835	29	2	1900	2	PPP2R1B	11	111636039	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3529602	111636039	23370477	330	22944											
BCO2	83875	broad.mit.edu	37	chr11	112071361	112071361	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaggaactatataattttCattgaacaacctctaaagat	18	12	4	7	0	2	2	1	1	1	1	2	3	2	3	1	1	3	0	1	1	9	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:112071361C>T	uc001pnf.2	+	7	1008	c.891C>T	c.(889-891)TTC>TTT	p.F297F	BCO2_uc001pne.1_Silent_p.F124F|BCO2_uc001png.2_Silent_p.F224F|BCO2_uc001pnh.2_Silent_p.F263F|BCO2_uc010rwt.1_Silent_p.F192F|BCO2_uc009yyn.2_Silent_p.F263F|BCO2_uc001pni.2_Silent_p.F263F	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	297					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						ATATAATTTTCATTGAACAAC	0.383													13	57					0	0	0	0	T	112071361	T	T	112071361	2	4	128	1	0	0	0	0	0	0	0	1	1387	825	29	2		2	BCO2	11	112071361	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	435322	112071361	22935155	331	22945											
DDX6	1656	broad.mit.edu	37	chr11	118633977	118633977	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctactcctttcttaataaGatccaggattctcccagggg	9	13	8	11	0	2	1	0	0	2	1	5	2	4	2	3	3	2	1	3	3	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:118633977G>T	uc001pub.2	-	7	1046	c.685C>A	c.(685-687)CTT>ATT	p.L229I	DDX6_uc001puc.2_Missense_Mutation_p.L229I	NM_004397	NP_004388	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	229	Helicase ATP-binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		TTCTTAATAAGATCCAGGATT	0.368			T	IGH@	B-NHL								17	121					1.67942e-08	1.779e-08	1	0	T	118633977	T	T	118633977	3	4	128	1	0	0	0	0	1	0	0	0	4394	942	33	2	794	2	DDX6	11	118633977	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	6562616	118633977	16372539	332	22946											
NTM	50863	broad.mit.edu	37	chr11	131781512	131781512	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagctatggacaacgtgaCggtccggcagggggagagcg	11	4	17	9	4	0	2	0	1	0	1	1	4	1	3	1	5	3	2	1	5	3	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:131781512C>T	uc001qgp.2	+	1	801	c.137C>T	c.(136-138)ACG>ATG	p.T46M	NTM_uc001qgm.2_Missense_Mutation_p.T46M|NTM_uc010sch.1_Missense_Mutation_p.T37M|NTM_uc010sci.1_Missense_Mutation_p.T46M|NTM_uc010scj.1_Missense_Mutation_p.T5M|NTM_uc001qgo.2_Missense_Mutation_p.T46M|NTM_uc001qgq.2_Missense_Mutation_p.T46M	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	46	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						GACAACGTGACGGTCCGGCAG	0.617											OREG0021537	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	84					0	0	0	0	T	131781512	T	T	131781512	3	4	128	1	0	0	0	0	1	0	0	0	10753	536	19	1	225	1	NTM	11	131781512	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	13147535	131781512	3225004	333	22947											
WNK1	65125	broad.mit.edu	37	chr12	996423	996423	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaacttccagcaggtactCtacccagcgagcagctgcca	10	7	9	15	1	1	1	0	1	1	0	2	2	2	1	3	1	8	4	3	1	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:996423C>T	uc001qio.3	+	20	5824	c.5317C>T	c.(5317-5319)CTA>TTA	p.L1773L	WNK1_uc001qip.3_Silent_p.L1526L|WNK1_uc001qir.3_Silent_p.L946L	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1773					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			AGCAGGTACTCTACCCAGCGA	0.483													16	102					0	0	0	0	T	996423	T	T	996423	2	4	128	1	0	0	0	0	0	0	0	1	17445	912	32	2		2	WNK1	12	996423	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08		996423	132855472	334	22948											
DYRK4	8798	broad.mit.edu	37	chr12	4721834	4721834	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccaattcctttttcccctCtgagacaaggaaggacaagg	12	10	8	11	0	1	1	0	1	1	1	4	4	4	3	4	3	0	0	4	3	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:4721834C>T	uc001qmx.2	+	12	1431	c.1271C>T	c.(1270-1272)TCT>TTT	p.S424F	DYRK4_uc009zeh.1_Missense_Mutation_p.S539F|DYRK4_uc001qmy.1_Missense_Mutation_p.S424F|DYRK4_uc001qmz.1_Missense_Mutation_p.S138F|DYRK4_uc001qna.1_Missense_Mutation_p.S61F|DYRK4_uc010ser.1_Missense_Mutation_p.S61F	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	424						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			TTTTTCCCCTCTGAGACAAGG	0.522													17	102					0	0	0	0	T	4721834	T	T	4721834	3	4	128	1	0	0	0	0	1	0	0	0	4880	913	32	2	1309	2	DYRK4	12	4721834	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3725411	4721834	129130061	335	22949											
USP5	8078	broad.mit.edu	37	chr12	6966015	6966015	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taccgagagacaggctacccGttagctgtcaagctgggcac	10	7	12	12	2	1	1	1	0	0	1	1	3	1	1	2	2	4	5	2	2	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:6966015G>A	uc001qri.3	+	6	788	c.729G>A	c.(727-729)CCG>CCA	p.P243P	USP5_uc001qrh.3_Silent_p.P243P	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	243	UBP-type.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						CAGGCTACCCGTTAGCTGTCA	0.537													9	48					0	0	0	0	A	6966015	A	A	6966015	2	1	128	1	0	0	0	0	0	0	0	1	17149	1132	40	1		1	USP5	12	6966015	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2244181	6966015	126885880	336	22950											
C1S	716	broad.mit.edu	37	chr12	7169796	7169796	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtgcattgtcctgttttCacttttggcatgggtttatg	5	18	11	7	0	1	0	1	0	0	0	2	0	2	0	1	3	1	4	1	3	1	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:7169796C>T	uc001qsj.2	+	6	742	c.23C>T	c.(22-24)TCA>TTA	p.S8L	C1S_uc001qsk.2_Missense_Mutation_p.S8L|C1S_uc001qsl.2_Missense_Mutation_p.S8L|C1S_uc009zfr.2_Intron|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	8					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GTCCTGTTTTCACTTTTGGCA	0.502													9	69					0	0	0	0	T	7169796	T	T	7169796	3	4	128	1	0	0	0	0	1	0	0	0	1983	838	29	2	29	2	C1S	12	7169796	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	203781	7169796	126682099	337	22951											
TAS2R50	259296	broad.mit.edu	37	chr12	11138872	11138872	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagagaacagattagcatCagaaaagatatcagggacag	19	5	10	7	0	2	4	2	0	0	4	2	6	2	5	0	1	2	1	0	1	5	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:11138872C>T	uc001qzl.2	-	1	640	c.588G>A	c.(586-588)CTG>CTA	p.L196L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	196	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						AGATTAGCATCAGAAAAGATA	0.408													23	132					0	0	0	0	T	11138872	T	T	11138872	2	4	128	1	0	0	0	0	0	0	0	1	15650	813	29	2		2	TAS2R50	12	11138872	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3969076	11138872	122713023	338	22952											
PRB3	5544	broad.mit.edu	37	chr12	11420963	11420963	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccttctggctttcctggacGaggtgggggaccttgggact	4	12	15	10	1	1	0	0	0	1	0	3	4	3	3	3	6	0	1	3	6	0	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:11420963G>A	uc001qzs.2	-	3	258	c.220C>T	c.(220-222)CGT>TGT	p.R74C	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	74	2.|10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TTTCCTGGACGAGGTGGGGGA	0.627													49	386					0	0	0	0	A	11420963	A	A	11420963	3	1	128	1	0	0	0	0	1	0	0	0	12506	1058	37	1	717	1	PRB3	12	11420963	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	282091	11420963	122430932	339	22953											
ETV6	2120	broad.mit.edu	37	chr12	12043951	12043951	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagagtcccaggagctggatGaacaaatataccaagaagat	17	7	10	7	0	0	4	0	1	0	3	1	6	1	6	2	2	3	1	2	2	7	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:12043951G>A	uc001qzz.2	+	8	1604	c.1330G>A	c.(1330-1332)GAA>AAA	p.E444K	ETV6_uc001raa.1_Intron	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	444						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				GGAGCTGGATGAACAAATATA	0.527			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								29	145					0	0	0	0	A	12043951	A	A	12043951	3	1	128	1	0	0	0	0	1	0	0	0	5307	1291	45	2	1360	2	ETV6	12	12043951	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	622988	12043951	121807944	340	22954											
DUSP16	80824	broad.mit.edu	37	chr12	12629840	12629840	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttccccagctcttcccgtGacctgttctctgacatgatg	5	14	7	15	1	2	3	0	3	2	0	5	3	4	3	4	0	1	2	4	0	0	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:12629840G>A	uc001rao.1	-	7	2557	c.1925C>T	c.(1924-1926)TCA>TTA	p.S642L	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.S494L	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	642					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		CTCTTCCCGTGACCTGTTCTC	0.498													36	205					0	0	0	0	A	12629840	A	A	12629840	3	1	128	1	0	0	0	0	1	0	0	0	4838	1294	45	2	76	2	DUSP16	12	12629840	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	585889	12629840	121222055	341	22955											
ERP27	121506	broad.mit.edu	37	chr12	15090892	15090892	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtagggaactaacctggaaGaagcctatgacagccacctc	14	6	10	11	0	0	2	0	1	0	1	1	4	0	4	4	2	4	1	4	2	6	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:15090892G>C	uc001rco.2	-	2	210	c.189C>G	c.(187-189)TTC>TTG	p.F63L		NM_152321	NP_689534	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27 kDa precursor	63	Thioredoxin.					endoplasmic reticulum lumen				breast(1)	1						TAACCTGGAAGAAGCCTATGA	0.547													15	118					0	0	0	0	C	15090892	C	C	15090892	3	2	128	1	0	0	0	0	1	0	0	0	5265	933	33	2	656	2	ERP27	12	15090892	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2461052	15090892	118761003	342	22956											
ABCC9	10060	broad.mit.edu	37	chr12	22069956	22069956	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatgcagaaacgcaggtttGatatgtccaagccagactga	13	9	11	8	1	0	5	0	3	0	2	1	5	1	5	2	1	3	3	2	1	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:22069956G>C	uc001rfi.1	-	4	508	c.488C>G	c.(487-489)TCA>TGA	p.S163*	ABCC9_uc001rfh.2_Nonsense_Mutation_p.S163*|ABCC9_uc001rfj.1_Nonsense_Mutation_p.S163*	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	163	Extracellular (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACGCAGGTTTGATATGTCCAA	0.418													33	187					0	0	0	0	C	22069956	C	C	22069956	4	2	128	1	0	0	0	0	0	1	0	0	59	1294	45	2	4443	2	ABCC9	12	22069956	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	6979064	22069956	111781939	343	22957											
CAPRIN2	65981	broad.mit.edu	37	chr12	30876222	30876222	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcttgaagaaaatcactttGactggacagattttgttctt	11	16	7	7	0	3	4	1	2	2	2	3	5	3	5	0	1	0	1	0	1	3	6	rs79465544		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:30876222G>A	uc001rji.1	-	11	2765	c.2014C>T	c.(2014-2016)CAA>TAA	p.Q672*	CAPRIN2_uc001rjf.1_Nonsense_Mutation_p.Q469*|CAPRIN2_uc001rjg.1_Nonsense_Mutation_p.Q339*|CAPRIN2_uc001rjh.1_Nonsense_Mutation_p.Q672*|CAPRIN2_uc001rjj.1_Nonsense_Mutation_p.Q339*|CAPRIN2_uc001rjk.3_Nonsense_Mutation_p.Q672*|CAPRIN2_uc001rjl.3_Nonsense_Mutation_p.Q672*|CAPRIN2_uc001rjm.1_Nonsense_Mutation_p.Q339*	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	672					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AAATCACTTTGACTGGACAGA	0.358													7	71					0	0	0	0	A	30876222	A	A	30876222	4	1	128	1	0	0	0	0	0	1	0	0	2648	1299	45	2	1401	2	CAPRIN2	12	30876222	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	8806266	30876222	102975673	344	22958											
DNM1L	10059	broad.mit.edu	37	chr12	32873662	32873662	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgtgatgagtatgcttttCttcaaaagaaatatccatct	12	15	6	8	1	3	3	1	2	2	1	5	3	5	3	2	0	1	2	2	0	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:32873662C>G	uc001rld.2	+	8	966	c.805C>G	c.(805-807)CTT>GTT	p.L269V	DNM1L_uc010skf.1_RNA|DNM1L_uc010skg.1_RNA|DNM1L_uc001rle.2_Missense_Mutation_p.L269V|DNM1L_uc001rlf.2_Missense_Mutation_p.L269V|DNM1L_uc010skh.1_Missense_Mutation_p.L335V|DNM1L_uc001rlg.2_Missense_Mutation_p.L335V|DNM1L_uc001rlh.2_Missense_Mutation_p.L322V|DNM1L_uc010ski.1_Missense_Mutation_p.L66V	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	269	GTPase domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GTATGCTTTTCTTCAAAAGAA	0.343													11	61					0	0	0	0	G	32873662	G	G	32873662	3	3	128	1	0	0	0	0	1	0	0	0	4693	913	32	2	835	2	DNM1L	12	32873662	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1997440	32873662	100978233	345	22959											
ABCD2	225	broad.mit.edu	37	chr12	39967597	39967597	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatatctttccttcgacatCaatgctgacagcactggtac	12	12	6	11	1	2	1	1	1	1	0	4	2	3	1	1	1	3	3	1	1	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:39967597C>T	uc001rmb.2	-	9	2350	c.1924G>A	c.(1924-1926)GAT>AAT	p.D642N		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	642	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						CCTTCGACATCAATGCTGACA	0.353													7	71					0	0	0	0	T	39967597	T	T	39967597	3	4	128	1	0	0	0	0	1	0	0	0	61	826	29	2	306	2	ABCD2	12	39967597	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	7093935	39967597	93884298	346	22960											
ADAMTS20	80070	broad.mit.edu	37	chr12	43846363	43846363	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acattagagggaatgccactGatgtccaaatgtttaccatt	13	12	8	8	0	0	2	0	1	0	1	1	3	1	3	3	1	2	1	3	1	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:43846363G>A	uc010skx.1	-	13	1896	c.1896C>T	c.(1894-1896)ATC>ATT	p.I632I		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	632	Cys-rich.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GAATGCCACTGATGTCCAAAT	0.388													7	36					0	0	0	0	A	43846363	A	A	43846363	2	1	128	1	0	0	0	0	0	0	0	1	266	1280	45	2		2	ADAMTS20	12	43846363	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3878766	43846363	90005532	347	22961											
HDAC7	51564	broad.mit.edu	37	chr12	48179624	48179624	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctccaaggccagcaccactgCgcctcctgccaggttcatca	8	7	8	18	1	2	0	2	0	0	0	4	0	4	0	6	2	3	2	6	2	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:48179624C>T	uc010slo.1	-	23	2812	c.2617G>A	c.(2617-2619)GCA>ACA	p.A873T	HDAC7_uc009zku.2_RNA|HDAC7_uc001rqe.2_Missense_Mutation_p.A307T|HDAC7_uc001rqj.3_Missense_Mutation_p.A836T|HDAC7_uc001rqk.3_Missense_Mutation_p.A856T|HDAC7_uc010slp.1_Missense_Mutation_p.A117T	NM_015401	NP_056216	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7 isoform a	834	Histone deacetylase.				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		AGCACCACTGCGCCTCCTGCC	0.602													7	37					0	0	0	0	T	48179624	T	T	48179624	3	4	128	1	0	0	0	0	1	0	0	0	7051	768	27	1	374	1	HDAC7	12	48179624	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	4333261	48179624	85672271	348	22962											
DNAJC22	79962	broad.mit.edu	37	chr12	49742881	49742881	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagaggggtgacaccccctCtgagtcccattcgctttgct	6	10	10	15	1	1	3	0	2	1	1	3	3	2	3	4	2	1	2	4	2	0	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:49742881C>G	uc001rua.2	+	2	627	c.226C>G	c.(226-228)CTG>GTG	p.L76V	DNAJC22_uc001rub.2_Missense_Mutation_p.L76V	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	76					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						GACACCCCCTCTGAGTCCCAT	0.557													18	123					0	0	0	0	G	49742881	G	G	49742881	3	3	128	1	0	0	0	0	1	0	0	0	4663	912	32	2	228	2	DNAJC22	12	49742881	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1563257	49742881	84109014	349	22963											
KCNH3	23416	broad.mit.edu	37	chr12	49944103	49944103	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaagggtggcaccgtgctcGccatcctaggtttgtgaggg	6	10	15	10	2	1	1	1	1	0	0	3	1	2	1	3	4	1	3	3	4	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:49944103G>A	uc001ruh.1	+	10	2169	c.1909G>A	c.(1909-1911)GCC>ACC	p.A637T	KCNH3_uc010smj.1_Missense_Mutation_p.A577T	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	637	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						CACCGTGCTCGCCATCCTAGG	0.622													10	56					0	0	0	0	A	49944103	A	A	49944103	3	1	128	1	0	0	0	0	1	0	0	0	8072	1087	38	1	1947	1	KCNH3	12	49944103	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	201222	49944103	83907792	350	22964											
TMBIM6	7009	broad.mit.edu	37	chr12	50152485	50152485	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtatcttgatgtcagccctGagcttgttgcttttgtcttc	4	18	10	9	0	3	2	1	2	2	0	4	2	3	2	1	1	3	4	1	1	1	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:50152485G>A	uc001rux.2	+	7	585	c.453G>A	c.(451-453)CTG>CTA	p.L151L	TMBIM6_uc010sml.1_Intron|TMBIM6_uc001ruy.2_Silent_p.L209L|TMBIM6_uc001ruz.2_Silent_p.L151L	NM_003217	NP_003208	P55061	BI1_HUMAN	testis enhanced gene transcript (BAX inhibitor	151	Helical; (Potential).				apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus					0						TGTCAGCCCTGAGCTTGTTGC	0.443													21	79					0	0	0	0	A	50152485	A	A	50152485	2	1	128	1	0	0	0	0	0	0	0	1	16049	1277	45	2		2	TMBIM6	12	50152485	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	208382	50152485	83699410	351	22965											
TARBP2	6895	broad.mit.edu	37	chr12	53895890	53895890	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagggaagacgcctgtgtacGaccttctcaaagccgagggc	10	7	13	11	3	1	1	1	0	1	1	2	4	1	2	3	2	2	1	3	2	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:53895890G>A	uc001sdo.2	+	2	633	c.145G>A	c.(145-147)GAC>AAC	p.D49N	MAP3K12_uc001sdm.1_5'Flank|MAP3K12_uc001sdn.1_5'Flank|TARBP2_uc009znb.2_Missense_Mutation_p.D49N|TARBP2_uc001sdp.2_Missense_Mutation_p.D28N|TARBP2_uc001sdq.2_5'UTR|TARBP2_uc001sdr.2_5'UTR|TARBP2_uc001sds.2_Missense_Mutation_p.D49N|TARBP2_uc001sdt.2_Missense_Mutation_p.D28N|TARBP2_uc001sdu.2_5'UTR|TARBP2_uc001sdv.2_RNA	NM_134323	NP_599150	Q15633	TRBP2_HUMAN	TAR RNA binding protein 2 isoform a	49	Sufficient for interaction with PRKRA.|DRBM 1.				miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)	1						GCCTGTGTACGACCTTCTCAA	0.592													13	55					0	0	0	0	A	53895890	A	A	53895890	3	1	128	1	0	0	0	0	1	0	0	0	15622	1058	37	1	151	1	TARBP2	12	53895890	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3743405	53895890	79956005	352	22966											
STAT2	6773	broad.mit.edu	37	chr12	56737683	56737683	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcactggctgtgatacaggtCcttggtctggctctggcact	5	12	13	11	0	2	1	0	1	2	0	3	1	3	1	1	5	1	4	1	5	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:56737683C>T	uc001slc.2	-	23	2417	c.2339G>A	c.(2338-2340)GGA>GAA	p.G780E	STAT2_uc001slb.2_Missense_Mutation_p.G322E|STAT2_uc001sld.2_Missense_Mutation_p.G776E	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	780					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TGATACAGGTCCTTGGTCTGG	0.458													7	159					0	0	0	0	T	56737683	T	T	56737683	3	4	128	1	0	0	0	0	1	0	0	0	15331	855	30	2	224	2	STAT2	12	56737683	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2841793	56737683	77114212	353	22967											
SLC26A10	65012	broad.mit.edu	37	chr12	58019209	58019209	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagctggccagccgatgtcGagatgctaggatccgcctcc	7	7	13	14	3	0	1	0	0	0	1	3	4	2	2	5	2	3	3	5	2	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:58019209G>A	uc001spe.2	+	13	1801	c.1490G>A	c.(1489-1491)CGA>CAA	p.R497Q	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_Intron	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	497	STAS.					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					AGCCGATGTCGAGATGCTAGG	0.582													8	36					0	0	0	0	A	58019209	A	A	58019209	3	1	128	1	0	0	0	0	1	0	0	0	14579	1058	37	1	1540	1	SLC26A10	12	58019209	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1281526	58019209	75832686	354	22968											
THAP2	83591	broad.mit.edu	37	chr12	72068122	72068122	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taacaggacaaactcgacgaCttaaaatggatgctgttcca	15	9	8	9	2	0	0	0	0	0	0	2	4	1	2	1	2	3	2	1	2	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:72068122C>A	uc001swq.2	+	2	717	c.211C>A	c.(211-213)CTT>ATT	p.L71I		NM_031435	NP_113623	Q9H0W7	THAP2_HUMAN	THAP domain containing, apoptosis associated	71	THAP-type.					nucleolus	DNA binding|metal ion binding			ovary(1)	1						AACTCGACGACTTAAAATGGA	0.368													15	69					2.31682e-05	2.40789e-05	1	0	A	72068122	A	A	72068122	3	1	128	1	0	0	0	0	1	0	0	0	15910	565	20	4	217	4	THAP2	12	72068122	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	14048913	72068122	61783773	355	22969											
TPH2	121278	broad.mit.edu	37	chr12	72335507	72335507	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtaaaagcactgaggctCtttcaggtgaatgtgaaata	13	12	11	5	0	2	3	1	3	1	0	2	3	2	3	0	3	1	3	0	3	5	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:72335507C>G	uc009zrw.1	+	2	390	c.249C>G	c.(247-249)CTC>CTG	p.L83L	TPH2_uc001swy.2_5'UTR	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	83	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	CACTGAGGCTCTTTCAGGTGA	0.403													9	94					0	0	0	0	G	72335507	G	G	72335507	2	3	128	1	0	0	0	0	0	0	0	1	16469	900	32	2		2	TPH2	12	72335507	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	267385	72335507	61516388	356	22970											
KCNC2	3747	broad.mit.edu	37	chr12	75437009	75437009	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctatgttgtttaagcttcggGatttttcatatccttttatg	7	21	7	6	1	1	0	1	0	0	0	3	1	2	1	1	1	1	3	1	1	4	10			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:75437009G>A	uc001sxg.1	-	5	2337	c.1793C>T	c.(1792-1794)TCC>TTC	p.S598F	KCNC2_uc009zry.2_Intron|KCNC2_uc001sxe.2_Intron|KCNC2_uc001sxf.2_Intron|KCNC2_uc010stw.1_Missense_Mutation_p.S543F	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	598	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						TAAGCTTCGGGATTTTTCATA	0.433													5	42					0	0	0	0	A	75437009	A	A	75437009	3	1	128	1	0	0	0	0	1	0	0	0	8054	1174	41	2	193	2	KCNC2	12	75437009	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3101502	75437009	58414886	357	22971											
HSP90B1	7184	broad.mit.edu	37	chr12	104336982	104336982	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaagaggttccagaatgttgCcaaggaaggagtgaagttcg	13	8	15	5	1	0	3	0	1	0	2	2	6	1	5	2	3	1	3	2	3	5	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:104336982C>G	uc001tkb.1	+	13	1880	c.1775C>G	c.(1774-1776)GCC>GGC	p.A592G	HSP90B1_uc010swg.1_Missense_Mutation_p.A257G|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	592					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CAGAATGTTGCCAAGGAAGGA	0.418													11	68					0	0	0	0	G	104336982	G	G	104336982	3	3	128	1	0	0	0	0	1	0	0	0	7442	739	26	4	1825	4	HSP90B1	12	104336982	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	28899973	104336982	29514913	358	22972											
PWP1	11137	broad.mit.edu	37	chr12	108091362	108091362	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttcaaaaaagaagaaaaaGaaaggaaagaaggtaaagaa	26	4	9	2	0	1	5	1	0	0	5	1	6	1	6	0	2	0	1	0	2	12	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:108091362G>C	uc001tmo.1	+	7	819	c.732G>C	c.(730-732)AAG>AAC	p.K244N	PWP1_uc001tmn.1_RNA|PWP1_uc009zuu.1_Missense_Mutation_p.K244N	NM_007062	NP_008993	Q13610	PWP1_HUMAN	periodic tryptophan protein 1	244					transcription, DNA-dependent	nucleus					0						AGAAGAAAAAGAAAGGAAAGA	0.378													11	24					0	0	0	0	C	108091362	C	C	108091362	3	2	128	1	0	0	0	0	1	0	0	0	12908	933	33	2	758	2	PWP1	12	108091362	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3754380	108091362	25760533	359	22973											
TRPV4	59341	broad.mit.edu	37	chr12	110252302	110252302	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgagtccatgggtgctttCttgggcccaggcaccaccga	7	9	13	12	1	1	1	0	1	1	0	2	2	2	1	4	3	1	2	4	3	0	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:110252302C>T	uc001tpj.1	-	1	395	c.300G>A	c.(298-300)AAG>AAA	p.K100K	TRPV4_uc001tpg.1_Silent_p.K66K|TRPV4_uc001tph.1_Silent_p.K100K|TRPV4_uc001tpi.1_Silent_p.K100K|TRPV4_uc001tpk.1_Silent_p.K100K|TRPV4_uc001tpl.1_Silent_p.K100K	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	100	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TGGGTGCTTTCTTGGGCCCAG	0.552													8	40					0	0	0	0	T	110252302	T	T	110252302	2	4	128	1	0	0	0	0	0	0	0	1	16665	912	32	2		2	TRPV4	12	110252302	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2160940	110252302	23599593	360	22974											
CUX2	23316	broad.mit.edu	37	chr12	111776184	111776184	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctggcacaagctgagcctGaaggggcgggagccttttgt	7	8	15	11	1	0	2	0	2	0	0	0	3	0	3	3	4	3	2	3	4	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:111776184G>A	uc001tsa.1	+	20	3444	c.3291G>A	c.(3289-3291)CTG>CTA	p.L1097L		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1097	CUT 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						AGCTGAGCCTGAAGGGGCGGG	0.592													13	49					0	0	0	0	A	111776184	A	A	111776184	2	1	128	1	0	0	0	0	0	0	0	1	4082	1277	45	2		2	CUX2	12	111776184	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1523882	111776184	22075711	361	22975											
FBXO21	23014	broad.mit.edu	37	chr12	117627050	117627050	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgtgctctgaaaagaacctCtttgagaacgaggctacaat	14	9	9	9	2	2	3	0	2	2	2	2	5	2	3	1	1	4	2	1	1	6	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:117627050C>G	uc001twk.2	-	2	396	c.357G>C	c.(355-357)AAG>AAC	p.K119N	FBXO21_uc001twj.2_Missense_Mutation_p.K119N|FBXO21_uc009zwq.2_Missense_Mutation_p.K119N	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	119					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		AAAAGAACCTCTTTGAGAACG	0.488													13	85					0	0	0	0	G	117627050	G	G	117627050	3	3	128	1	0	0	0	0	1	0	0	0	5765	912	32	2	1573	2	FBXO21	12	117627050	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5850866	117627050	16224845	362	22976											
CIT	11113	broad.mit.edu	37	chr12	120204897	120204897	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaaatgtctttactttaatCttttcctcatagtgctgctc	9	18	5	9	0	3	0	1	0	2	0	5	1	4	0	1	0	3	2	1	0	5	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:120204897C>G	uc001txi.1	-	18	2225	c.2172G>C	c.(2170-2172)AAG>AAC	p.K724N	CIT_uc001txh.1_Missense_Mutation_p.K258N|CIT_uc001txj.1_Missense_Mutation_p.K766N	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	724	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TTACTTTAATCTTTTCCTCAT	0.488													30	164					0	0	0	0	G	120204897	G	G	120204897	3	3	128	1	0	0	0	0	1	0	0	0	3453	912	32	2	4031	2	CIT	12	120204897	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2577847	120204897	13646998	363	22977											
SBNO1	55206	broad.mit.edu	37	chr12	123804454	123804454	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagtaaaacataccttatctCcatccataaatcgttgtttt	13	15	3	10	1	1	0	0	0	1	0	4	0	2	0	3	0	2	3	3	0	6	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:123804454C>G	uc010tap.1	-	19	2792	c.2792G>C	c.(2791-2793)GGA>GCA	p.G931A	SBNO1_uc010tao.1_Missense_Mutation_p.G930A|SBNO1_uc010taq.1_Intron	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	931							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TACCTTATCTCCATCCATAAA	0.338													6	41					0	0	0	0	G	123804454	G	G	123804454	3	3	128	1	0	0	0	0	1	0	0	0	13927	855	30	2	1441	2	SBNO1	12	123804454	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3599557	123804454	10047441	364	22978											
SBNO1	55206	broad.mit.edu	37	chr12	123805101	123805101	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttcatctgctgagccctttCcacagcatcctgacttgtta	7	14	6	14	0	2	2	1	2	1	0	4	2	4	2	3	0	3	3	3	0	1	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:123805101C>T	uc010tap.1	-	18	2545	c.2545G>A	c.(2545-2547)GAA>AAA	p.E849K	SBNO1_uc010tao.1_Missense_Mutation_p.E848K|SBNO1_uc010taq.1_Intron	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	849	Potential.						ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TGAGCCCTTTCCACAGCATCC	0.383													30	118					0	0	0	0	T	123805101	T	T	123805101	3	4	128	1	0	0	0	0	1	0	0	0	13927	864	30	2	1692	2	SBNO1	12	123805101	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	647	123805101	10046794	365	22979											
SBNO1	55206	broad.mit.edu	37	chr12	123810101	123810101	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccgccctcttccaaagcttCtaatgttctagcttctcctg	6	14	5	16	1	4	0	0	0	4	0	6	0	5	0	4	0	2	3	4	0	3	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:123810101C>T	uc010tap.1	-	14	1921	c.1921G>A	c.(1921-1923)GAA>AAA	p.E641K	SBNO1_uc010tao.1_Missense_Mutation_p.E640K|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.E641K|SBNO1_uc001ueu.2_Missense_Mutation_p.E640K|SBNO1_uc001uev.2_Missense_Mutation_p.E639K|SBNO1_uc009zxy.1_Missense_Mutation_p.E606K	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	641							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TCCAAAGCTTCTAATGTTCTA	0.343													31	204					0	0	0	0	T	123810101	T	T	123810101	3	4	128	1	0	0	0	0	1	0	0	0	13927	922	32	2	2332	2	SBNO1	12	123810101	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5000	123810101	10041794	366	22980											
TMEM132D	121256	broad.mit.edu	37	chr12	129558534	129558534	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctactcatcacgatggagttCctggtggggtactcgtcgtc	6	12	12	11	3	2	0	2	0	0	0	6	2	3	1	1	4	2	2	1	4	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:129558534C>A	uc009zyl.1	-	9	3514	c.3186G>T	c.(3184-3186)AGG>AGT	p.R1062S	TMEM132D_uc001uia.2_Missense_Mutation_p.R600S	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	1062	Cytoplasmic (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CGATGGAGTTCCTGGTGGGGT	0.517													23	111					2.39556e-15	2.57475e-15	1	0	A	129558534	A	A	129558534	3	1	128	1	0	0	0	0	1	0	0	0	16113	854	30	2	117	2	TMEM132D	12	129558534	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5748433	129558534	4293361	367	22981											
TMEM132D	121256	broad.mit.edu	37	chr12	130184842	130184842	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacggcagcttctccccggCgctgcggtcgtcccagtctc	3	8	12	18	5	2	0	0	0	2	0	6	0	3	0	3	3	2	4	3	3	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:130184842C>T	uc009zyl.1	-	2	809	c.481G>A	c.(481-483)GCC>ACC	p.A161T		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	161	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTCTCCCCGGCGCTGCGGTCG	0.642													3	22					0	0	0	0	T	130184842	T	T	130184842	3	4	128	1	0	0	0	0	1	0	0	0	16113	768	27	1	2850	1	TMEM132D	12	130184842	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	626308	130184842	3667053	368	22982											
ULK1	8408	broad.mit.edu	37	chr12	132404537	132404537	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgcagtggtgcgcaggctGaatgagctgtacaaggccag	9	9	15	8	1	0	2	0	2	0	0	0	2	0	2	1	3	4	5	1	3	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:132404537G>A	uc001uje.2	+	26	3085	c.2817G>A	c.(2815-2817)CTG>CTA	p.L939L		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	939					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TGCGCAGGCTGAATGAGCTGT	0.647													5	44					0	0	0	0	A	132404537	A	A	132404537	2	1	128	1	0	0	0	0	0	0	0	1	17043	1277	45	2		2	ULK1	12	132404537	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2219695	132404537	1447358	369	22983											
EP400	57634	broad.mit.edu	37	chr12	132498089	132498089	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaataccttcctggagctCtggaccatggtgcacttcct	8	11	8	14	0	1	0	0	0	1	0	3	2	3	2	4	3	3	2	4	3	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:132498089C>T	uc001ujn.2	+	17	3701	c.3666C>T	c.(3664-3666)CTC>CTT	p.L1222L	EP400_uc001ujl.2_Silent_p.L1221L|EP400_uc001ujm.2_Silent_p.L1222L	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1258	Interactions with RUVBL1 and RUVBL2.|Helicase ATP-binding.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TCCTGGAGCTCTGGACCATGG	0.572													13	86					0	0	0	0	T	132498089	T	T	132498089	2	4	128	1	0	0	0	0	0	0	0	1	5173	900	32	2		2	EP400	12	132498089	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	93552	132498089	1353806	370	22984											
GOLGA3	2802	broad.mit.edu	37	chr12	133358996	133358996	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcccgtaagcttccctttCtcgtgctctaattcaagagc	8	12	8	13	2	3	1	1	0	2	1	5	1	4	1	2	1	3	3	2	1	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:133358996C>T	uc001ukz.1	-	17	3910	c.3351G>A	c.(3349-3351)GAG>GAA	p.E1117E	GOLGA3_uc001ula.1_Silent_p.E1117E	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1117	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCTTCCCTTTCTCGTGCTCTA	0.493													33	157					0	0	0	0	T	133358996	T	T	133358996	2	4	128	1	0	0	0	0	0	0	0	1	6591	912	32	2		2	GOLGA3	12	133358996	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	860907	133358996	492899	371	22985											
ATP12A	479	broad.mit.edu	37	chr13	25263408	25263408	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttctcacccaggtgtacttGggctgtgtgcttggtctggt	3	15	13	10	0	2	0	1	0	2	0	3	0	2	0	1	4	2	3	1	4	1	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr13:25263408G>A	uc001upp.2	+	5	628	c.441G>A	c.(439-441)TTG>TTA	p.L147L	ATP12A_uc010aaa.2_Silent_p.L147L	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	147	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AGGTGTACTTGGGCTGTGTGC	0.532													19	187					0	0	0	0	A	25263408	A	A	25263408	2	1	128	1	0	0	0	0	0	0	0	1	1124	1339	47	4		4	ATP12A	13	25263408	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08		25263408	89906470	372	22986											
C13orf23	80209	broad.mit.edu	37	chr13	39588581	39588581	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgaaggattagaaccatgagGagaaaagagttgacttgctg	15	9	13	4	0	0	6	0	3	0	3	0	8	0	7	1	2	2	2	1	2	5	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr13:39588581G>C	uc001uwy.2	-	11	1681	c.808C>G	c.(808-810)CCT>GCT	p.P270A	C13orf23_uc001uwz.2_Missense_Mutation_p.P248A	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	270	Pro-rich.									ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		GAACCATGAGGAGAAAAGAGT	0.433													5	31					0	0	0	0	C	39588581	C	C	39588581	3	2	128	1	0	0	0	0	1	0	0	0	1727	1174	41	2	2038	2	C13orf23	13	39588581	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	14325173	39588581	75581297	373	22987											
FNDC3A	22862	broad.mit.edu	37	chr13	49771891	49771891	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaatggaacagatgtcactGaatatcgactggagtgggga	13	9	14	5	1	1	2	1	1	0	1	2	6	1	5	0	4	1	1	0	4	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr13:49771891G>A	uc001vcm.2	+	21	2676	c.2371G>A	c.(2371-2373)GAA>AAA	p.E791K	FNDC3A_uc001vcn.2_Missense_Mutation_p.E791K|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Missense_Mutation_p.E735K	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	791	Fibronectin type-III 6.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		AGATGTCACTGAATATCGACT	0.388													21	73					0	0	0	0	A	49771891	A	A	49771891	3	1	128	1	0	0	0	0	1	0	0	0	6001	1291	45	2	2460	2	FNDC3A	13	49771891	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	10183310	49771891	65397987	374	22988											
RBM26	64062	broad.mit.edu	37	chr13	79952987	79952987	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taactctttttcacttttgtCtttctttaccaaagccagaa	10	18	3	10	0	4	1	1	0	3	1	4	1	4	1	2	0	3	0	2	0	4	8			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr13:79952987C>G	uc001vkz.2	-	2	141	c.127G>C	c.(127-129)GAC>CAC	p.D43H	RBM26_uc001vky.2_Missense_Mutation_p.D43H|RBM26_uc001vla.2_Missense_Mutation_p.D43H|RBM26_uc001vlc.1_Missense_Mutation_p.D43H	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	43					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TCACTTTTGTCTTTCTTTACC	0.328													4	27					0	0	0	0	G	79952987	G	G	79952987	3	3	128	1	0	0	0	0	1	0	0	0	13191	913	32	2	2895	2	RBM26	13	79952987	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	30181096	79952987	35216891	375	22989											
NPAS3	64067	broad.mit.edu	37	chr14	34145537	34145537	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctgtcacagggcactgctGaggacggagccagctcagca	9	6	13	13	1	2	1	2	1	0	0	3	3	3	3	2	3	4	4	2	3	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:34145537G>A	uc001wru.2	+	6	743	c.679G>A	c.(679-681)GAG>AAG	p.E227K	NPAS3_uc001wrs.2_Missense_Mutation_p.E214K|NPAS3_uc001wrt.2_Missense_Mutation_p.E195K|NPAS3_uc001wrv.2_Missense_Mutation_p.E197K|NPAS3_uc001wrw.2_Missense_Mutation_p.E125K	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	227					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GGGCACTGCTGAGGACGGAGC	0.617													9	43					0	0	0	0	A	34145537	A	A	34145537	3	1	128	1	0	0	0	0	1	0	0	0	10618	1291	45	2	756	2	NPAS3	14	34145537	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08		34145537	73204003	376	22990											
RALGAPA1	253959	broad.mit.edu	37	chr14	36143457	36143457	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaggggaggtcaggttatCagttgaaatgccaaggttat	13	10	14	4	0	2	2	2	1	0	1	2	3	2	3	1	5	1	3	1	5	5	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:36143457C>T	uc001wti.2	-	23	3719	c.3328G>A	c.(3328-3330)GAT>AAT	p.D1110N	RALGAPA1_uc010amp.2_5'Flank|RALGAPA1_uc001wtj.2_Missense_Mutation_p.D1110N|RALGAPA1_uc010tpv.1_Missense_Mutation_p.D1123N|RALGAPA1_uc010tpw.1_Missense_Mutation_p.D1157N	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1110					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						GTCAGGTTATCAGTTGAAATG	0.318													6	20					0	0	0	0	T	36143457	T	T	36143457	3	4	128	1	0	0	0	0	1	0	0	0	13078	826	29	2	3007	2	RALGAPA1	14	36143457	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1997920	36143457	71206083	377	22991											
FANCM	57697	broad.mit.edu	37	chr14	45606317	45606317	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaatatggtgcagtaagaGagtgctttttcttacacctc	11	13	10	7	0	1	1	0	0	1	1	2	3	1	2	1	2	3	3	1	2	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:45606317G>C	uc001wwd.3	+	2	653	c.554G>C	c.(553-555)AGA>ACA	p.R185T	FANCM_uc001wwc.2_Missense_Mutation_p.R185T|FANCM_uc010anf.2_Missense_Mutation_p.R185T|FKBP3_uc010tqf.1_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	185	Helicase ATP-binding.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TGCAGTAAGAGAGTGCTTTTT	0.373								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				8	63					0	0	0	0	C	45606317	C	C	45606317	3	2	128	1	0	0	0	0	1	0	0	0	5703	942	33	2	560	2	FANCM	14	45606317	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	9462860	45606317	61743223	378	22992											
FANCM	57697	broad.mit.edu	37	chr14	45644452	45644452	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatcctcagtgatagaatCtgatgaagaatgtgctgaaa	14	12	9	6	0	3	6	2	4	1	2	4	6	4	6	1	0	1	1	1	0	5	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:45644452C>G	uc001wwd.3	+	14	2594	c.2495C>G	c.(2494-2496)TCT>TGT	p.S832C	FANCM_uc010anf.2_Missense_Mutation_p.S806C|FANCM_uc001wwe.3_Missense_Mutation_p.S368C|FANCM_uc010ang.2_Missense_Mutation_p.S46C	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	832					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						GTGATAGAATCTGATGAAGAA	0.294								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				10	33					0	0	0	0	G	45644452	G	G	45644452	3	3	128	1	0	0	0	0	1	0	0	0	5703	913	32	2	2549	2	FANCM	14	45644452	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	38135	45644452	61705088	379	22993											
FANCM	57697	broad.mit.edu	37	chr14	45665674	45665674	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgtcaataagaacaagttCattgagcagatccagcacct	15	9	8	9	0	2	3	2	1	0	2	3	3	3	3	2	0	3	3	2	0	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:45665674C>T	uc001wwd.3	+	21	5739	c.5640C>T	c.(5638-5640)TTC>TTT	p.F1880F	FANCM_uc010anf.2_Silent_p.F1854F|FANCM_uc001wwe.3_Silent_p.F1416F|FANCM_uc010ang.2_Silent_p.F1129F	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1880	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						AGAACAAGTTCATTGAGCAGA	0.368								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				17	71					0	0	0	0	T	45665674	T	T	45665674	2	4	128	1	0	0	0	0	0	0	0	1	5703	825	29	2		2	FANCM	14	45665674	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	21222	45665674	61683866	380	22994											
NIN	51199	broad.mit.edu	37	chr14	51208379	51208379	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccttttcctgctgagtcactCgtaggtcagatttcatccgg	6	14	9	12	2	3	2	3	1	0	1	6	2	5	2	3	2	1	2	3	2	1	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:51208379C>T	uc001wym.2	-	25	5560	c.5369G>A	c.(5368-5370)CGA>CAA	p.R1790Q	NIN_uc001wyi.2_Missense_Mutation_p.R1790Q|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.R1077Q|NIN_uc010tqp.1_Missense_Mutation_p.R1796Q|NIN_uc001wyo.2_Missense_Mutation_p.R1790Q|NIN_uc001wyn.2_5'Flank	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1790	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					CTGAGTCACTCGTAGGTCAGA	0.393			T	PDGFRB	MPD								28	144					0	0	0	0	T	51208379	T	T	51208379	3	4	128	1	0	0	0	0	1	0	0	0	10471	884	31	1	1208	1	NIN	14	51208379	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	5542705	51208379	56141161	381	22995											
CDKN3	1033	broad.mit.edu	37	chr14	54875501	54875501	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagaagaaatgtccaaaaaGatacaggtaggtataatatc	19	10	8	4	0	0	3	0	0	0	3	2	3	1	3	1	2	1	2	1	2	10	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:54875501G>C	uc001xap.2	+	4	301	c.187G>C	c.(187-189)GAT>CAT	p.D63H	CDKN3_uc001xar.2_Missense_Mutation_p.D23H|CDKN3_uc001xaq.2_Missense_Mutation_p.D63H|CDKN3_uc010aoi.1_RNA|CDKN3_uc001xas.1_Intron|CDKN3_uc010aoj.1_Intron	NM_005192	NP_005183	Q16667	CDKN3_HUMAN	cyclin-dependent kinase inhibitor 3 isoform 1	63					cell cycle arrest|G1/S transition of mitotic cell cycle|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	perinuclear region of cytoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0						TGTCCAAAAAGATACAGGTAG	0.279													15	92					0	0	0	0	C	54875501	C	C	54875501	3	2	128	1	0	0	0	0	1	0	0	0	3182	942	33	2	201	2	CDKN3	14	54875501	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3667122	54875501	52474039	382	22996											
KIAA0586	9786	broad.mit.edu	37	chr14	58932685	58932685	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatttgttcagcccaagtaGagaaatgcctactttttcag	12	14	7	8	0	2	1	2	0	0	1	2	2	2	1	2	0	3	2	2	0	5	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:58932685G>A	uc001xdv.3	+	14	2237	c.1964G>A	c.(1963-1965)AGA>AAA	p.R655K	KIAA0586_uc010trr.1_Missense_Mutation_p.R772K|KIAA0586_uc001xdt.3_Missense_Mutation_p.R687K|KIAA0586_uc001xdu.3_Missense_Mutation_p.R716K|KIAA0586_uc010trs.1_Missense_Mutation_p.R646K|KIAA0586_uc010trt.1_Missense_Mutation_p.R591K|KIAA0586_uc010tru.1_Missense_Mutation_p.R591K	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	655										ovary(1)	1						AGCCCAAGTAGAGAAATGCCT	0.358													6	166					0	0	0	0	A	58932685	A	A	58932685	3	1	128	1	0	0	0	0	1	0	0	0	8225	942	33	2	2018	2	KIAA0586	14	58932685	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4057184	58932685	48416855	383	22997											
PLEKHG3	26030	broad.mit.edu	37	chr14	65198093	65198093	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgcaggagattcagtcactCctcatcaactggaaggggcc	10	8	11	12	0	4	1	4	0	0	1	5	3	5	2	2	4	2	1	2	4	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:65198093C>G	uc001xho.1	+	8	1133	c.864C>G	c.(862-864)CTC>CTG	p.L288L	PLEKHG3_uc001xhn.1_Silent_p.L232L|PLEKHG3_uc001xhp.2_Silent_p.L288L|PLEKHG3_uc010aqh.1_5'UTR	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	288					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TTCAGTCACTCCTCATCAACT	0.602													5	33					0	0	0	0	G	65198093	G	G	65198093	2	3	128	1	0	0	0	0	0	0	0	1	12125	842	30	2		2	PLEKHG3	14	65198093	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	6265408	65198093	42151447	384	22998											
RBM25	58517	broad.mit.edu	37	chr14	73566393	73566393	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaggatataaatgctataGaaatggaagaagacaaaaga	22	6	11	2	0	0	4	0	0	0	4	0	7	0	7	0	3	1	1	0	3	10	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:73566393G>T	uc001xno.2	+	9	1010	c.802G>T	c.(802-804)GAA>TAA	p.E268*	RBM25_uc001xnn.3_Nonsense_Mutation_p.E268*|RBM25_uc010ttu.1_Nonsense_Mutation_p.E268*|RBM25_uc001xnp.2_Nonsense_Mutation_p.E63*	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	268					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		AAATGCTATAGAAATGGAAGA	0.348													18	90					1.50039e-11	1.60219e-11	1	0	T	73566393	T	T	73566393	4	4	128	1	0	0	0	0	0	1	0	0	13190	943	33	2	832	2	RBM25	14	73566393	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	8368300	73566393	33783147	385	22999											
HEATR4	399671	broad.mit.edu	37	chr14	73989358	73989358	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctggatgcatgcagggatGatggatgagagggcggggtg	9	8	20	4	1	1	2	0	2	1	1	1	6	1	5	0	6	2	2	0	6	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:73989358G>A	uc010tub.1	-	3	821	c.499C>T	c.(499-501)CAT>TAT	p.H167Y	HEATR4_uc010tua.1_Missense_Mutation_p.H120Y	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		ATGCAGGGATGATGGATGAGA	0.562													9	46					0	0	0	0	A	73989358	A	A	73989358	3	1	128	1	0	0	0	0	1	0	0	0	7069	1290	45	2	2645	2	HEATR4	14	73989358	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	422965	73989358	33360182	386	23000											
NEK9	91754	broad.mit.edu	37	chr14	75568401	75568401	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttgcctggggcaatggtaCggatcttataaaaggacaac	12	10	11	8	1	2	0	0	0	2	0	2	2	2	2	1	5	3	2	1	5	6	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:75568401C>T	uc001xrl.2	-	15	1953	c.1799G>A	c.(1798-1800)CGT>CAT	p.R600H	NEK9_uc001xrk.2_Missense_Mutation_p.R100H	NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	600	RCC1 4.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)		GGCAATGGTACGGATCTTATA	0.413													17	146					0	0	0	0	T	75568401	T	T	75568401	3	4	128	1	0	0	0	0	1	0	0	0	10385	536	19	1	1172	1	NEK9	14	75568401	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1579043	75568401	31781139	387	23001											
ALKBH1	8846	broad.mit.edu	37	chr14	78146284	78146284	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagtttctccagtaaacttCggggtctccgtttagtcgct	6	14	10	11	3	2	0	0	0	2	0	6	0	2	0	2	2	1	5	2	2	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:78146284C>T	uc001xuc.1	-	4	494	c.485G>A	c.(484-486)CGA>CAA	p.R162Q	ALKBH1_uc001xud.1_RNA	NM_006020	NP_006011	Q13686	ALKB1_HUMAN	alkylated DNA repair protein alkB homolog	162					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)|skin(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		CAGTAAACTTCGGGGTCTCCG	0.398													15	94					0	0	0	0	T	78146284	T	T	78146284	3	4	128	1	0	0	0	0	1	0	0	0	526	884	31	1	696	1	ALKBH1	14	78146284	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2577883	78146284	29203256	388	23002											
FAM181A	90050	broad.mit.edu	37	chr14	94394757	94394757	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccatcgcaagtacctgcaGaagcagctcaagcgcttctc	11	7	9	14	2	2	1	1	0	1	1	4	2	2	1	2	0	5	6	2	0	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:94394757G>A	uc001ybz.1	+	3	619	c.312G>A	c.(310-312)CAG>CAA	p.Q104Q	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Silent_p.Q42Q|FAM181A_uc001yca.1_Silent_p.Q42Q	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	104											0						AGTACCTGCAGAAGCAGCTCA	0.632													5	22					0	0	0	0	A	94394757	A	A	94394757	2	1	128	1	0	0	0	0	0	0	0	1	5536	933	33	2		2	FAM181A	14	94394757	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	16248473	94394757	12954783	389	23003											
MTA1	9112	broad.mit.edu	37	chr14	105936499	105936499	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagccaggccctgccgccgCggccaccgccacctgcgccc	5	2	12	22	5	0	1	0	0	0	1	0	1	0	1	9	2	3	0	9	2	0	0	rs146041220	byFrequency	TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:105936499C>T	uc001yqx.2	+	21	2282	c.2095C>T	c.(2095-2097)CGG>TGG	p.R699W	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Missense_Mutation_p.R464W|CRIP2_uc010tyr.1_5'Flank|CRIP2_uc001yrc.2_5'Flank	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	699	Poly-Pro.|SH3-binding (Potential).				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CCTGCCGCCGCGGCCACCGCC	0.567													5	17					0	0	0	0	T	105936499	T	T	105936499	3	4	128	1	0	0	0	0	1	0	0	0	9961	759	27	1	2177	1	MTA1	14	105936499	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	11541742	105936499	1413041	390	23004											
HERC2	8924	broad.mit.edu	37	chr15	28413555	28413555	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttagattcgcttttacctCtctcttttcttgccatggat	5	20	5	11	1	3	1	0	0	3	1	5	2	3	2	2	1	2	1	2	1	2	8			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:28413555C>G	uc001zbj.2	-	67	10517	c.10411G>C	c.(10411-10413)GAG>CAG	p.E3471Q		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3471					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCTTTTACCTCTCTCTTTTCT	0.428													25	125					0	0	0	0	G	28413555	G	G	28413555	3	3	128	1	0	0	0	0	1	0	0	0	7097	922	32	2	4201	2	HERC2	15	28413555	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08		28413555	74117837	391	23005											
HERC2	8924	broad.mit.edu	37	chr15	28459835	28459835	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtcagaggagcaggtagtGagcaagcttcccaagaagtc	13	6	13	9	1	1	3	1	1	0	2	3	4	2	4	1	2	3	4	1	2	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:28459835G>A	uc001zbj.2	-	40	6430	c.6324C>T	c.(6322-6324)CTC>CTT	p.L2108L		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2108					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AGCAGGTAGTGAGCAAGCTTC	0.562													5	22					0	0	0	0	A	28459835	A	A	28459835	2	1	128	1	0	0	0	0	0	0	0	1	7097	1277	45	2		2	HERC2	15	28459835	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	46280	28459835	74071557	392	23006											
TRPM1	4308	broad.mit.edu	37	chr15	31323259	31323259	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagatgtttcgggccagtttCcaagagggcttctcctctgg	7	12	12	10	1	2	2	0	0	2	2	5	2	3	2	3	3	0	3	3	3	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:31323259C>T	uc001zfm.2	-	22	3116	c.2988G>A	c.(2986-2988)TGG>TGA	p.W996*	TRPM1_uc010azy.2_Nonsense_Mutation_p.W903*|TRPM1_uc001zfl.2_Intron	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	996	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GGGCCAGTTTCCAAGAGGGCT	0.478													12	99					0	0	0	0	T	31323259	T	T	31323259	4	4	128	1	0	0	0	0	0	1	0	0	16652	856	30	2	1847	2	TRPM1	15	31323259	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2863424	31323259	71208133	393	23007											
FMN1	342184	broad.mit.edu	37	chr15	33359906	33359906	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggattcacgtctaaactatgGaatgctttcagcacagcatc	12	11	8	10	1	3	0	2	0	1	0	4	2	3	2	0	2	4	3	0	2	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:33359906G>A	uc001zhf.3	-	1	180	c.180C>T	c.(178-180)TTC>TTT	p.F60F	FMN1_uc001zhg.2_Silent_p.F60F	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:Variant_position_missing_in_Q68DA7_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CTAAACTATGGAATGCTTTCA	0.453													10	71					0	0	0	0	A	33359906	A	A	33359906	2	1	128	1	0	0	0	0	0	0	0	1	5981	1165	41	2		2	FMN1	15	33359906	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2036647	33359906	69171486	394	23008											
C15orf55	256646	broad.mit.edu	37	chr15	34648777	34648777	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caagaacagagctgtgaaacCgtagggcatcccagtgatct	13	7	11	10	1	1	4	0	2	1	2	2	4	2	4	2	1	3	3	2	1	4	1	rs137916466		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:34648777C>T	uc001zif.2	+	7	2639	c.2484C>T	c.(2482-2484)ACC>ACT	p.T828T	C15orf55_uc010ucc.1_Silent_p.T856T|C15orf55_uc010ucd.1_Silent_p.T846T	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	828						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GCTGTGAAACCGTAGGGCATC	0.507			T	BRD3|BRD4	lethal midline carcinoma								11	60					0	0	0	0	T	34648777	T	T	34648777	2	4	128	1	0	0	0	0	0	0	0	1	1809	639	23	1		1	C15orf55	15	34648777	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1288871	34648777	67882615	395	23009											
MAPKBP1	23005	broad.mit.edu	37	chr15	42110227	42110227	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gatatttaacatcagcagtgGaaagcagaagaagctgttta	16	10	10	5	0	1	2	1	0	0	2	1	4	1	3	0	1	4	4	0	1	6	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:42110227G>C	uc001zok.3	+	18	2229	c.1943G>C	c.(1942-1944)GGA>GCA	p.G648A	MAPKBP1_uc001zoj.3_Missense_Mutation_p.G642A|MAPKBP1_uc010bcj.2_Missense_Mutation_p.G149A|MAPKBP1_uc010bci.2_Missense_Mutation_p.G642A|MAPKBP1_uc010udb.1_Missense_Mutation_p.G481A|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Missense_Mutation_p.G149A	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	648	WD 10.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		ATCAGCAGTGGAAAGCAGAAG	0.517													28	140					0	0	0	0	C	42110227	C	C	42110227	3	2	128	1	0	0	0	0	1	0	0	0	9345	1174	41	2	2009	2	MAPKBP1	15	42110227	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7461450	42110227	60421165	396	23010											
TGM5	9333	broad.mit.edu	37	chr15	43552604	43552604	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctggggttcttaccagtttCaaccacgaagatgatgttgt	9	13	11	8	1	2	2	1	1	1	1	2	3	2	2	2	2	2	4	2	2	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:43552604C>G	uc001zrd.1	-	2	192	c.184G>C	c.(184-186)GAA>CAA	p.E62Q	TGM5_uc001zre.1_Missense_Mutation_p.E62Q	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	62					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	TTACCAGTTTCAACCACGAAG	0.597													5	49					0	0	0	0	G	43552604	G	G	43552604	3	3	128	1	0	0	0	0	1	0	0	0	15899	835	29	2	2026	2	TGM5	15	43552604	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1442377	43552604	58978788	397	23011											
MAP1A	4130	broad.mit.edu	37	chr15	43814069	43814069	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccttatctctcctgagcttgGagttgtctttttcaacgtgc	5	17	8	11	1	3	1	1	1	2	0	5	2	4	2	2	1	3	2	2	1	2	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:43814069G>C	uc001zrt.2	+	4	865	c.398G>C	c.(397-399)GGA>GCA	p.G133A		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	133						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCTGAGCTTGGAGTTGTCTTT	0.557													13	51					0	0	0	0	C	43814069	C	C	43814069	3	2	128	1	0	0	0	0	1	0	0	0	9280	1174	41	2	400	2	MAP1A	15	43814069	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	261465	43814069	58717323	398	23012											
PPIP5K1	9677	broad.mit.edu	37	chr15	43827592	43827592	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttagggagggttgatcactGaagccaaattgggagttacc	11	11	13	6	0	1	2	1	2	0	0	1	4	1	4	2	3	2	2	2	3	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:43827592G>A	uc001zrw.2	-	31	3765	c.3582C>T	c.(3580-3582)TTC>TTT	p.F1194F	PPIP5K1_uc001zrx.1_Silent_p.F1167F|PPIP5K1_uc001zru.2_Silent_p.F1169F|PPIP5K1_uc001zry.3_Silent_p.F1169F|PPIP5K1_uc001zrv.2_Intron	NM_001130858	NP_001124330	Q6PFW1	VIP1_HUMAN	histidine acid phosphatase domain containing 2A	1194					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity				0						GTTGATCACTGAAGCCAAATT	0.522													16	85					0	0	0	0	A	43827592	A	A	43827592	2	1	128	1	0	0	0	0	0	0	0	1	12392	1281	45	2		2	PPIP5K1	15	43827592	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	13523	43827592	58703800	399	23013											
DMXL2	23312	broad.mit.edu	37	chr15	51790872	51790872	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagacttgagtgcataagatGacttgaaagtacccttgcat	13	12	9	7	0	0	5	0	3	0	2	0	5	0	5	1	0	3	3	1	0	4	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:51790872G>A	uc002abf.2	-	18	4774	c.4549C>T	c.(4549-4551)CAT>TAT	p.H1517Y	DMXL2_uc010ufy.1_Missense_Mutation_p.H1517Y|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1517						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TGCATAAGATGACTTGAAAGT	0.408													19	46					0	0	0	0	A	51790872	A	A	51790872	3	1	128	1	0	0	0	0	1	0	0	0	4617	1290	45	2	4668	2	DMXL2	15	51790872	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7963280	51790872	50740520	400	23014											
THSD4	79875	broad.mit.edu	37	chr15	71535293	71535293	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaggctaccctgcagcttCaagtctctttcacagcccag	9	10	7	15	0	4	0	3	0	1	0	5	0	4	0	2	1	4	3	2	1	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:71535293C>T	uc002atb.1	+	4	849	c.770C>T	c.(769-771)TCA>TTA	p.S257L	THSD4_uc002atd.1_5'UTR	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	257	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						CCTGCAGCTTCAAGTCTCTTT	0.562													17	64					0	0	0	0	T	71535293	T	T	71535293	3	4	128	1	0	0	0	0	1	0	0	0	15944	838	29	2	784	2	THSD4	15	71535293	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	19744421	71535293	30996099	401	23015											
C15orf27	123591	broad.mit.edu	37	chr15	76496185	76496185	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctctctggacatgcccctCaaactcggcggtaatggcac	8	10	9	14	2	3	0	1	0	2	0	5	1	3	1	2	4	2	2	2	4	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:76496185C>G	uc002bbq.2	+	11	1280	c.1125C>G	c.(1123-1125)CTC>CTG	p.L375L	C15orf27_uc010bkp.2_Silent_p.L191L|C15orf27_uc002bbr.2_Silent_p.L191L|C15orf27_uc002bbs.2_Silent_p.L53L	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	375						integral to membrane					0						ACATGCCCCTCAAACTCGGCG	0.632													23	103					0	0	0	0	G	76496185	G	G	76496185	2	3	128	1	0	0	0	0	0	0	0	1	1794	813	29	2		2	C15orf27	15	76496185	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	4960892	76496185	26035207	402	23016											
C15orf27	123591	broad.mit.edu	37	chr15	76496280	76496280	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagcagccagacgctgggctCctccatggactgcagcactg	8	6	12	15	1	0	1	0	0	0	1	2	2	2	2	3	2	4	5	3	2	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:76496280C>T	uc002bbq.2	+	11	1375	c.1220C>T	c.(1219-1221)TCC>TTC	p.S407F	C15orf27_uc010bkp.2_Missense_Mutation_p.S223F|C15orf27_uc002bbr.2_Missense_Mutation_p.S223F|C15orf27_uc002bbs.2_Missense_Mutation_p.S85F	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	407						integral to membrane					0						ACGCTGGGCTCCTCCATGGAC	0.697													9	30					0	0	0	0	T	76496280	T	T	76496280	3	4	128	1	0	0	0	0	1	0	0	0	1794	855	30	2	1258	2	C15orf27	15	76496280	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	95	76496280	26035112	403	23017											
IL16	3603	broad.mit.edu	37	chr15	81575003	81575003	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccggcgtgggcctgggcatcGgcctgtgcagcgttccctac	3	8	15	15	4	0	0	0	0	0	0	2	0	1	0	4	4	3	3	4	4	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:81575003G>A	uc002bgh.3	+	9	1481	c.1105G>A	c.(1105-1107)GGC>AGC	p.G369S	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.G369S|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.G411S|IL16_uc002bgg.2_Missense_Mutation_p.G369S|IL16_uc002bgi.1_5'UTR	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	369	PDZ 2.|Interaction with GRIN2A.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						CCTGGGCATCGGCCTGTGCAG	0.642													26	125					0	0	0	0	A	81575003	A	A	81575003	3	1	128	1	0	0	0	0	1	0	0	0	7672	1116	39	1	1135	1	IL16	15	81575003	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	5078723	81575003	20956389	404	23018											
ALPK3	57538	broad.mit.edu	37	chr15	85406114	85406114	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcccagcagtgagacttctCttgtgggcagaaactacgac	10	8	12	11	1	1	2	0	1	1	2	2	4	1	2	1	2	3	2	1	2	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:85406114C>T	uc002ble.2	+	10	5151	c.4984C>T	c.(4984-4986)CTT>TTT	p.L1662F	ALPK3_uc010upc.1_5'Flank	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1662	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGAGACTTCTCTTGTGGGCAG	0.557													17	95					0	0	0	0	T	85406114	T	T	85406114	3	4	128	1	0	0	0	0	1	0	0	0	546	913	32	2	5022	2	ALPK3	15	85406114	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3831111	85406114	17125278	405	23019											
ALPK3	57538	broad.mit.edu	37	chr15	85406847	85406847	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagcagaagcccgggccgCgcctggctttggggaggtgc	5	5	18	13	4	0	1	0	0	0	1	0	2	0	2	3	5	3	3	3	5	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:85406847C>T	uc002ble.2	+	11	5248	c.5081C>T	c.(5080-5082)GCG>GTG	p.A1694V	ALPK3_uc010upc.1_5'Flank	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1694	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCCGGGCCGCGCCTGGCTTT	0.557													6	21					0	0	0	0	T	85406847	T	T	85406847	3	4	128	1	0	0	0	0	1	0	0	0	546	768	27	1	5123	1	ALPK3	15	85406847	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	733	85406847	17124545	406	23020											
AEN	64782	broad.mit.edu	37	chr15	89173347	89173347	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacagccatggagctctaccGgctggtggaggtgcagtggg	7	7	18	9	1	1	0	0	0	1	0	1	3	1	2	2	6	4	3	2	6	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:89173347G>A	uc002bmt.2	+	4	951	c.800G>A	c.(799-801)CGG>CAG	p.R267Q	AEN_uc010bnm.1_Missense_Mutation_p.R267Q	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	267					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						GAGCTCTACCGGCTGGTGGAG	0.607													8	42					0	0	0	0	A	89173347	A	A	89173347	3	1	128	1	0	0	0	0	1	0	0	0	351	1116	39	1	810	1	AEN	15	89173347	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3766500	89173347	13358045	407	23021											
LINS1	55180	broad.mit.edu	37	chr15	101109585	101109585	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctggaagcattttactattCtgtaaaatattcccacttca	12	15	4	10	0	2	0	1	0	1	0	3	1	3	1	2	1	2	2	2	1	6	8	rs148450316		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:101109585C>T	uc002bwe.2	-	8	2423	c.2132G>A	c.(2131-2133)AGA>AAA	p.R711K	LINS1_uc002bwd.2_Missense_Mutation_p.R298K|LINS1_uc002bwf.2_Missense_Mutation_p.R711K|LINS1_uc002bwg.2_Missense_Mutation_p.R711K|LINS1_uc002bwh.2_Missense_Mutation_p.R711K	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	711											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			TTTTACTATTCTGTAAAATAT	0.383													24	124					0	0	0	0	T	101109585	T	T	101109585	3	4	128	1	0	0	0	0	1	0	0	0	8860	913	32	2	145	2	LINS1	15	101109585	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	11936238	101109585	1421807	408	23022											
OR4F6	390648	broad.mit.edu	37	chr15	102346152	102346152	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggtattttgttcctccaCagctcccaagatgatttatg	8	17	7	9	0	0	2	0	1	0	1	3	2	3	2	3	1	1	3	3	1	3	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:102346152C>T	uc010utr.1	+	1	230	c.230C>T	c.(229-231)ACA>ATA	p.T77I		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TGTTCCTCCACAGCTCCCAAG	0.463													49	253					0	0	0	0	T	102346152	T	T	102346152	3	4	128	1	0	0	0	0	1	0	0	0	11120	478	17	4	232	4	OR4F6	15	102346152	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1236567	102346152	185240	409	23023											
SOLH	6650	broad.mit.edu	37	chr16	599044	599044	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcccgggcccgagtctgtcGgcttccccgcgggtgacagc	3	7	14	17	5	1	1	0	1	1	0	4	2	3	1	4	3	1	1	4	3	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:599044G>A	uc002chi.2	+	5	1864	c.1501G>A	c.(1501-1503)GGC>AGC	p.G501S		NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	501	Calpain catalytic.				proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				CGAGTCTGTCGGCTTCCCCGC	0.657													31	90					0	0	0	0	A	599044	A	A	599044	3	1	128	1	0	0	0	0	1	0	0	0	14989	1116	39	1	1507	1	SOLH	16	599044	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08		599044	89755709	410	23024											
BAIAP3	8938	broad.mit.edu	37	chr16	1398119	1398119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgcctgccgaggcgtgcCgccgccgcgcggcctgtgtg	1	6	17	17	8	0	0	0	0	0	0	0	1	0	0	7	2	3	0	7	2	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:1398119C>T	uc002clk.1	+	33	3277	c.3277C>T	c.(3277-3279)CGC>TGC	p.R1093C	BAIAP3_uc002clj.2_Missense_Mutation_p.R1075C|BAIAP3_uc010uuz.1_Missense_Mutation_p.R1058C|BAIAP3_uc010uva.1_Missense_Mutation_p.R1030C|BAIAP3_uc010uvc.1_Missense_Mutation_p.R1022C	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	1093	C2 2.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				CGAGGCGTGCCGCCGCCGCGC	0.622													7	33					0	0	0	0	T	1398119	T	T	1398119	3	4	128	1	0	0	0	0	1	0	0	0	1306	652	23	1	3407	1	BAIAP3	16	1398119	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	799075	1398119	88956634	411	23025											
C16orf42	115939	broad.mit.edu	37	chr16	1399439	1399439	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatatgtgtctgcaaccctCagtctctctgccgtttcttg	6	16	7	12	1	5	0	1	0	4	0	6	0	5	0	2	0	3	2	2	0	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:1399439C>T	uc002cll.2	-	6	1006	c.938G>A	c.(937-939)TGA>TAA	p.*313*	BAIAP3_uc002clj.2_3'UTR|BAIAP3_uc010uuz.1_3'UTR|BAIAP3_uc010uva.1_3'UTR|BAIAP3_uc002clk.1_3'UTR|BAIAP3_uc010uvc.1_3'UTR|GNPTG_uc002clm.2_5'Flank	NM_001001410	NP_001001410	Q9UJK0	TSR3_HUMAN	hypothetical protein LOC115939	313					rRNA processing						0		Hepatocellular(780;0.0893)				CTGCAACCCTCAGTCTCTCTG	0.567													39	322					0	0	0	0	T	1399439	T	T	1399439	2	4	128	1	0	0	0	0	0	0	0	1	1819	837	29	2		2	C16orf42	16	1399439	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1320	1399439	88955314	412	23026											
C16orf42	115939	broad.mit.edu	37	chr16	1399524	1399524	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccctgcgtctgctcctcttCacagcagctgctgctggctc	3	12	9	17	1	3	0	1	0	2	0	6	0	5	0	2	1	6	6	2	1	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:1399524C>T	uc002cll.2	-	6	921	c.853G>A	c.(853-855)GAA>AAA	p.E285K	GNPTG_uc002clm.2_5'Flank	NM_001001410	NP_001001410	Q9UJK0	TSR3_HUMAN	hypothetical protein LOC115939	285					rRNA processing						0		Hepatocellular(780;0.0893)				TGCTCCTCTTCACAGCAGCTG	0.652													36	214					0	0	0	0	T	1399524	T	T	1399524	3	4	128	1	0	0	0	0	1	0	0	0	1819	835	29	2	89	2	C16orf42	16	1399524	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	85	1399524	88955229	413	23027											
MAPK8IP3	23162	broad.mit.edu	37	chr16	1816351	1816351	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattgcggcccgggcctctCacagagcacgtcttcactga	8	8	10	15	3	3	2	2	1	2	1	4	2	3	2	2	2	2	1	2	2	0	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:1816351C>A	uc002cmk.2	+	22	2877	c.2757C>A	c.(2755-2757)CTC>CTA	p.L919L	MAPK8IP3_uc002cml.2_Silent_p.L913L|MAPK8IP3_uc010uvl.1_Silent_p.L920L	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	919					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CCGGGCCTCTCACAGAGCACG	0.687													6	38					3.59834e-05	3.73391e-05	1	0	A	1816351	A	A	1816351	2	1	128	1	0	0	0	0	0	0	0	1	9339	813	29	2		2	MAPK8IP3	16	1816351	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	416827	1816351	88538402	414	23028											
SRRM2	23524	broad.mit.edu	37	chr16	2808519	2808519	+	Frame_Shift_Del	DEL	G	-	-																															tcaccaaccccaaagcagaaGaagaagaaaaagaagaaaga																										TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:2808519delG	uc002crk.2	+	5	1113	c.564delG	c.(562-564)AAGfs	p.K188fs	SRRM2_uc002crj.1_Frame_Shift_Del_p.K92fs|SRRM2_uc002crl.1_Frame_Shift_Del_p.K188fs|SRRM2_uc010bsu.1_Frame_Shift_Del_p.K92fs	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	188	Lys-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CAaagcagaagaagaagaaaa	0.413													---	---	---								-	2808519	-	-	2808519	7	5	128	1	0	1	0	1	0	0	0	0	15235	933	33	0	578	0	SRRM2	16	2808519	Frame_Shift_Del	DEL	G	TCGA-CR-6481-01A-11D-1870-08	992168	2808519	87546234	415	23029											
SRRM2	23524	broad.mit.edu	37	chr16	2811883	2811883	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctccagggtcccaccgaGagatttcttcttctcccaca	8	10	7	16	1	3	1	0	0	3	1	6	3	5	1	4	1	1	1	4	1	0	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:2811883G>T	uc002crk.2	+	11	1903	c.1354G>T	c.(1354-1356)GAG>TAG	p.E452*	SRRM2_uc002crj.1_Nonsense_Mutation_p.E356*|SRRM2_uc002crl.1_Nonsense_Mutation_p.E452*|SRRM2_uc010bsu.1_Nonsense_Mutation_p.E356*	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	452	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GTCCCACCGAGAGATTTCTTC	0.547													19	207					1.56452e-12	1.67882e-12	1	0	T	2811883	T	T	2811883	4	4	128	1	0	0	0	0	0	1	0	0	15235	943	33	2	1392	2	SRRM2	16	2811883	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3364	2811883	87542870	416	23030											
CREBBP	1387	broad.mit.edu	37	chr16	3830809	3830809	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccttacaccggtgctagaagGaggagctgctgttggtatag	9	10	14	8	1	0	1	0	0	0	1	0	3	0	3	2	4	4	5	2	4	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:3830809G>A	uc002cvv.2	-	8	1951	c.1747C>T	c.(1747-1749)CCT>TCT	p.P583S	CREBBP_uc002cvw.2_Missense_Mutation_p.P545S	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	583					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGCTAGAAGGAGGAGCTGCT	0.483			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				7	49					0	0	0	0	A	3830809	A	A	3830809	3	1	128	1	0	0	0	0	1	0	0	0	3876	1174	41	2	5677	2	CREBBP	16	3830809	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1018926	3830809	86523944	417	23031											
SEPT12	124404	broad.mit.edu	37	chr16	4835884	4835884	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcttcacacccttctcctCtatgactgtggagggagagc	8	10	10	13	0	3	2	1	1	2	1	4	4	3	3	2	2	2	1	2	2	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:4835884C>A	uc002cxq.2	-	4	439	c.298G>T	c.(298-300)GAG>TAG	p.E100*	SEPT12_uc002cxr.2_Nonsense_Mutation_p.E100*|SEPT12_uc010bty.2_RNA|uc002cxt.2_5'Flank	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	100					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						CCCTTCTCCTCTATGACTGTG	0.438													9	78					0.00621372	0.00630916	1	0	A	4835884	A	A	4835884	4	1	128	1	0	0	0	0	0	1	0	0	14127	922	32	2	806	2	SEPT12	16	4835884	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1005075	4835884	85518869	418	23032											
GRIN2A	2903	broad.mit.edu	37	chr16	9943615	9943615	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcattcctgccactcacttGattttgacgaacttccgaca	10	12	6	13	2	1	2	1	2	0	0	3	4	3	2	3	0	3	1	3	0	1	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:9943615G>C	uc002czo.3	-	5	1874	c.1326C>G	c.(1324-1326)ATC>ATG	p.I442M	GRIN2A_uc010uym.1_Missense_Mutation_p.I442M|GRIN2A_uc010uyn.1_Missense_Mutation_p.I285M|GRIN2A_uc002czr.3_Missense_Mutation_p.I442M	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	442	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCACTCACTTGATTTTGACGA	0.493													13	59					0	0	0	0	C	9943615	C	C	9943615	3	2	128	1	0	0	0	0	1	0	0	0	6818	1280	45	2	3104	2	GRIN2A	16	9943615	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	5107731	9943615	80411138	419	23033											
ABCC6	368	broad.mit.edu	37	chr16	16286777	16286777	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgagggcggagggccccagGagctggggatagaaggggca	9	3	22	7	1	0	2	0	1	0	1	0	5	0	5	2	8	1	2	2	8	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:16286777G>A	uc002den.3	-	11	1378	c.1341C>T	c.(1339-1341)CTC>CTT	p.L447L	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Silent_p.L459L	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	447	ABC transmembrane type-1 1.|Helical; Name=8; (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		AGGGCCCCAGGAGCTGGGGAT	0.438													14	59					0	0	0	0	A	16286777	A	A	16286777	2	1	128	1	0	0	0	0	0	0	0	1	57	1161	41	2		2	ABCC6	16	16286777	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	6343162	16286777	74067976	420	23034											
ZP2	7783	broad.mit.edu	37	chr16	21213295	21213295	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgcttggaggaaaatccGtccagagagcatgtatttcg	10	13	11	7	2	0	1	0	0	0	1	3	4	2	3	2	2	2	3	2	2	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:21213295G>A	uc002dii.2	-	12	1337	c.1337C>T	c.(1336-1338)ACG>ATG	p.T446M	ZP2_uc010bwn.1_Missense_Mutation_p.T485M	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	446	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		AGGAAAATCCGTCCAGAGAGC	0.363													17	81					0	0	0	0	A	21213295	A	A	21213295	3	1	128	1	0	0	0	0	1	0	0	0	18283	1145	40	1	932	1	ZP2	16	21213295	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4926518	21213295	69141458	421	23035											
ARHGAP17	55114	broad.mit.edu	37	chr16	24950751	24950751	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggggacagtcccacccccaGagctgctttcagccctagag	9	6	11	15	0	1	2	1	0	0	2	2	3	2	3	4	2	3	2	4	2	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:24950751G>A	uc002dnb.2	-	17	1751	c.1658C>T	c.(1657-1659)TCT>TTT	p.S553F	ARHGAP17_uc002dmy.2_5'Flank|ARHGAP17_uc002dmz.2_Missense_Mutation_p.S77F|ARHGAP17_uc002dna.2_Missense_Mutation_p.S280F|ARHGAP17_uc002dnc.2_Intron|ARHGAP17_uc010vcf.1_Intron	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	553	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CCCACCCCCAGAGCTGCTTTC	0.687													5	25					0	0	0	0	A	24950751	A	A	24950751	3	1	128	1	0	0	0	0	1	0	0	0	867	942	33	2	1003	2	ARHGAP17	16	24950751	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3737456	24950751	65404002	422	23036											
GTF3C1	2975	broad.mit.edu	37	chr16	27495572	27495572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggtttttgactatgtagcGagctcttcgtccaacggaat	8	14	11	8	3	1	1	0	1	1	0	3	3	2	2	1	2	3	3	1	2	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:27495572G>A	uc002dov.1	-	25	4001	c.3961C>T	c.(3961-3963)CGC>TGC	p.R1321C	GTF3C1_uc002dou.2_Missense_Mutation_p.R1321C	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1321						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						ACTATGTAGCGAGCTCTTCGT	0.488													25	54					0	0	0	0	A	27495572	A	A	27495572	3	1	128	1	0	0	0	0	1	0	0	0	6911	1058	37	1	2420	1	GTF3C1	16	27495572	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2544821	27495572	62859181	423	23037											
ZNF768	79724	broad.mit.edu	37	chr16	30537313	30537313	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatggtatctcttcgacttCatagtccccactgccttctt	8	15	5	13	1	3	0	1	0	2	0	6	1	4	0	3	1	1	1	3	1	3	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:30537313C>T	uc002dyk.3	-	2	324	c.148G>A	c.(148-150)GAA>AAA	p.E50K	ZNF768_uc010vex.1_Missense_Mutation_p.E19K|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.E19K	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	50					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						TCTTCgacttcatagtcccca	0.408													23	162					0	0	0	0	T	30537313	T	T	30537313	3	4	128	1	0	0	0	0	1	0	0	0	18208	835	29	2	1478	2	ZNF768	16	30537313	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3041741	30537313	59817440	424	23038											
GPR114	221188	broad.mit.edu	37	chr16	57597888	57597888	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctccaacacccactttttCaaggtcagtgtgatggcggg	8	12	10	11	1	3	1	2	1	1	0	4	1	3	1	2	3	1	0	2	3	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:57597888C>G	uc002elx.3	+	5	511	c.426C>G	c.(424-426)TTC>TTG	p.F142L	GPR114_uc010vhr.1_Missense_Mutation_p.F142L|GPR114_uc002ely.2_Missense_Mutation_p.F142L	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	142	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						CCCACTTTTTCAAGGTCAGTG	0.637													11	70					0	0	0	0	G	57597888	G	G	57597888	3	3	128	1	0	0	0	0	1	0	0	0	6669	825	29	2	440	2	GPR114	16	57597888	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	27060575	57597888	32756865	425	23039											
GPR114	221188	broad.mit.edu	37	chr16	57598964	57598964	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggatgaaaacaactcatctCtgctgaataactacgtcctg	14	10	7	10	1	2	2	1	2	1	0	4	3	3	3	1	1	5	1	1	1	6	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:57598964C>G	uc002elx.3	+	6	533	c.448C>G	c.(448-450)CTG>GTG	p.L150V	GPR114_uc010vhr.1_Missense_Mutation_p.L150V|GPR114_uc002ely.2_Missense_Mutation_p.L150V	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	150	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						CAACTCATCTCTGCTGAATAA	0.567													9	72					0	0	0	0	G	57598964	G	G	57598964	3	3	128	1	0	0	0	0	1	0	0	0	6669	912	32	2	466	2	GPR114	16	57598964	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1076	57598964	32755789	426	23040											
SLC38A7	55238	broad.mit.edu	37	chr16	58704061	58704061	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagagagtttggcttgaatGaggcacagccctgaaagaga	13	8	13	7	0	1	5	1	3	0	2	1	7	1	5	1	2	1	3	1	2	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:58704061G>A	uc002eod.1	-	11	1635	c.1242C>T	c.(1240-1242)CTC>CTT	p.L414L	SLC38A7_uc002eob.1_RNA|SLC38A7_uc002eoc.1_Intron|SLC38A7_uc010vil.1_Silent_p.L325L	NM_018231	NP_060701	Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	414	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						TGGCTTGAATGAGGCACAGCC	0.557													14	42					0	0	0	0	A	58704061	A	A	58704061	2	1	128	1	0	0	0	0	0	0	0	1	14673	1277	45	2		2	SLC38A7	16	58704061	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1105097	58704061	31650692	427	23041											
RLTPR	146206	broad.mit.edu	37	chr16	67680670	67680670	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actacaatggcttccctttcCgagaggagattcagtgggtg	9	11	12	9	1	1	2	1	0	0	2	3	4	3	2	2	3	1	1	2	3	2	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:67680670C>T	uc002etn.2	+	7	640	c.520C>T	c.(520-522)CGA>TGA	p.R174*	RLTPR_uc010cel.1_Nonsense_Mutation_p.R174*|RLTPR_uc010vjr.1_Nonsense_Mutation_p.R174*	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	174										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CTTCCCTTTCCGAGAGGAGAT	0.582													10	90					0	0	0	0	T	67680670	T	T	67680670	4	4	128	1	0	0	0	0	0	1	0	0	13459	644	23	1	546	1	RLTPR	16	67680670	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	8976609	67680670	22674083	428	23042											
THAP11	57215	broad.mit.edu	37	chr16	67876995	67876995	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tacagccggcgcccatcactCccactggagaagacgtgaag	11	5	11	14	3	1	3	1	1	0	2	2	4	2	3	3	2	2	0	3	2	3	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:67876995C>G	uc002euo.2	+	1	783	c.538C>G	c.(538-540)CCC>GCC	p.P180A	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		GCCCATCACTCCCACTGGAGA	0.647													19	132					0	0	0	0	G	67876995	G	G	67876995	3	3	128	1	0	0	0	0	1	0	0	0	15909	855	30	2	540	2	THAP11	16	67876995	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	196325	67876995	22477758	429	23043											
THAP11	57215	broad.mit.edu	37	chr16	67877127	67877127	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctggaggctgccgagtgcCctatgggcccccagttggtg	4	8	17	12	1	0	0	0	0	0	0	0	2	0	1	4	5	2	3	4	5	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:67877127C>T	uc002euo.2	+	1	915	c.670C>T	c.(670-672)CCT>TCT	p.P224S	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		TGCCGAGTGCCCTATGGGCCC	0.657													7	68					0	0	0	0	T	67877127	T	T	67877127	3	4	128	1	0	0	0	0	1	0	0	0	15909	623	22	4	672	4	THAP11	16	67877127	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	132	67877127	22477626	430	23044											
PSMB10	5699	broad.mit.edu	37	chr16	67969349	67969349	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcggctggaaccggtcttCtagcaccgccagggccgcgt	5	8	14	14	5	2	0	0	0	2	0	3	1	2	1	4	4	2	3	4	4	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:67969349C>T	uc002eux.1	-	6	633	c.532G>A	c.(532-534)GAA>AAA	p.E178K		NM_002801	NP_002792	P40306	PSB10_HUMAN	proteasome beta 10 subunit proprotein	178					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|humoral immune response|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		AACCGGTCTTCTAGCACCGCC	0.647													19	65					0	0	0	0	T	67969349	T	T	67969349	3	4	128	1	0	0	0	0	1	0	0	0	12737	922	32	2	301	2	PSMB10	16	67969349	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	92222	67969349	22385404	431	23045											
PSMB10	5699	broad.mit.edu	37	chr16	67970194	67970194	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgttagtggctcgcgtatCggcgcccagaatgaccccgt	7	9	12	13	6	0	2	0	1	0	1	3	2	0	2	3	2	0	3	3	2	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:67970194C>A	uc002eux.1	-	3	267	c.166G>T	c.(166-168)GAT>TAT	p.D56Y		NM_002801	NP_002792	P40306	PSB10_HUMAN	proteasome beta 10 subunit proprotein	56					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|humoral immune response|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		GCTCGCGTATCGGCGCCCAGA	0.632													8	53					0.00307968	0.00313662	1	0	A	67970194	A	A	67970194	3	1	128	1	0	0	0	0	1	0	0	0	12737	884	31	3	679	3	PSMB10	16	67970194	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	845	67970194	22384559	432	23046											
CDH3	1001	broad.mit.edu	37	chr16	68729708	68729708	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catcacccagctccaccgagGtctggaggccaggccggagg	8	4	14	15	2	2	0	1	0	1	0	3	3	3	2	5	6	1	1	5	6	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:68729708G>A	uc002ewf.2	+	15	3294	c.2162G>A	c.(2161-2163)GGT>GAT	p.G721D	CDH3_uc010vli.1_Missense_Mutation_p.G666D	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	721	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CTCCACCGAGGTCTGGAGGCC	0.602													7	64					0	0	0	0	A	68729708	A	A	68729708	3	1	128	1	0	0	0	0	1	0	0	0	3126	1261	44	4	2220	4	CDH3	16	68729708	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	759514	68729708	21625045	433	23047											
PMFBP1	83449	broad.mit.edu	37	chr16	72188118	72188118	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctgtctatacctcatcttCtttcagtttgcagtgatggt	7	18	7	9	0	6	1	2	1	4	0	6	1	6	1	1	1	2	2	1	1	2	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:72188118C>G	uc002fcc.3	-	4	578	c.406G>C	c.(406-408)GAA>CAA	p.E136Q	PMFBP1_uc002fcd.2_Missense_Mutation_p.E136Q|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_5'UTR	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	136										ovary(2)	2		Ovarian(137;0.179)				ACCTCATCTTCTTTCAGTTTG	0.463													19	99					0	0	0	0	G	72188118	G	G	72188118	3	3	128	1	0	0	0	0	1	0	0	0	12189	922	32	2	2749	2	PMFBP1	16	72188118	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3458410	72188118	18166635	434	23048											
PKD1L2	114780	broad.mit.edu	37	chr16	81209259	81209259	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccctgcacgattggtggcaGaaataactactgtcagcaca	12	8	9	12	1	1	1	1	0	0	1	1	2	1	1	2	2	4	3	2	2	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:81209259G>C	uc002fgh.1	-	15	2534	c.2534C>G	c.(2533-2535)TCT>TGT	p.S845C	PKD1L2_uc002fgg.1_RNA|PKD1L2_uc002fgi.2_Missense_Mutation_p.S160C|PKD1L2_uc002fgj.2_Missense_Mutation_p.S845C|PKD1L2_uc002fgk.1_5'UTR|PKD1L2_uc002fgl.1_Missense_Mutation_p.S101C	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	845	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ATTGGTGGCAGAAATAACTAC	0.532													14	61					0	0	0	0	C	81209259	C	C	81209259	3	2	128	1	0	0	0	0	1	0	0	0	12020	942	33	2	5030	2	PKD1L2	16	81209259	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	9021141	81209259	9145494	435	23049											
SPG7	6687	broad.mit.edu	37	chr16	89597147	89597147	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaagatggggaaaggagtCagcttcaaagacgtggcagg	13	5	18	5	1	2	2	2	0	0	2	2	5	2	5	0	6	1	2	0	6	3	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:89597147C>T	uc002fnj.2	+	7	939	c.918C>T	c.(916-918)GTC>GTT	p.V306V	SPG7_uc002fni.2_Silent_p.V306V	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	306	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GGAAAGGAGTCAGCTTCAAAG	0.517													8	79					0	0	0	0	T	89597147	T	T	89597147	2	4	128	1	0	0	0	0	0	0	0	1	15110	813	29	2		2	SPG7	16	89597147	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	8387888	89597147	757606	436	23050											
FANCA	2175	broad.mit.edu	37	chr16	89877208	89877208	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctaacagggaagacagcttCttctgaaaagagagattaca	16	9	9	7	0	3	4	0	1	3	3	3	6	3	5	0	1	3	1	0	1	5	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:89877208C>G	uc002fou.1	-	5	471	c.429G>C	c.(427-429)AAG>AAC	p.K143N	FANCA_uc010vpn.1_Missense_Mutation_p.K143N|FANCA_uc002fov.1_Missense_Mutation_p.K126N|FANCA_uc002fow.1_Missense_Mutation_p.K143N|FANCA_uc002fox.1_Missense_Mutation_p.K143N|FANCA_uc010ciu.1_Intron|FANCA_uc002foy.2_Missense_Mutation_p.K143N	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	143					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		AAGACAGCTTCTTCTGAAAAG	0.348			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				20	105					0	0	0	0	G	89877208	G	G	89877208	3	3	128	1	0	0	0	0	1	0	0	0	5694	912	32	2	4099	2	FANCA	16	89877208	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	280061	89877208	477545	437	23051											
MYBBP1A	10514	broad.mit.edu	37	chr17	4457189	4457189	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcctgcagcagcttcacCgacttcatcagtgcctcctg	7	9	10	15	1	3	0	3	0	0	0	4	1	4	0	4	1	4	3	4	1	0	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:4457189C>G	uc002fyb.3	-	5	539	c.477G>C	c.(475-477)TCG>TCC	p.S159S	MYBBP1A_uc002fxz.3_Silent_p.S159S	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	159	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						GCAGCTTCACCGACTTCATCA	0.627													4	19					0	0	0	0	G	4457189	G	G	4457189	2	3	128	1	0	0	0	0	0	0	0	1	10061	639	23	3		3	MYBBP1A	17	4457189	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08		4457189	76738021	438	23052											
SMTNL2	342527	broad.mit.edu	37	chr17	4510765	4510765	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtcgctgtacaaccacCtgcgtcgcttcgagtaaagc	9	9	9	14	4	0	0	0	0	0	0	4	1	1	0	3	0	4	4	3	0	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:4510765C>T	uc002fyf.1	+	8	1436	c.1369C>T	c.(1369-1371)CTG>TTG	p.L457L	SMTNL2_uc002fye.2_Silent_p.L313L|uc002fyg.1_5'Flank	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	457											0				READ - Rectum adenocarcinoma(115;0.0325)		GTACAACCACCTGCGTCGCTT	0.617													22	94					0	0	0	0	T	4510765	T	T	4510765	2	4	128	1	0	0	0	0	0	0	0	1	14880	680	24	4		4	SMTNL2	17	4510765	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	53576	4510765	76684445	439	23053											
MIS12	79003	broad.mit.edu	37	chr17	5392414	5392414	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaaggacattttgataacCtttttagcaaaatggagcaa	16	12	8	5	0	0	2	0	2	0	0	0	4	0	4	1	2	3	2	1	2	6	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:5392414C>G	uc002gcd.2	+	2	561	c.232C>G	c.(232-234)CTT>GTT	p.L78V	DERL2_uc002gcc.1_5'Flank|MIS12_uc002gce.2_Missense_Mutation_p.L78V	NM_024039	NP_076944	Q9H081	MIS12_HUMAN	MIS12 homolog	78					cell division|chromosome segregation|kinetochore assembly|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding				0						TTTTGATAACCTTTTTAGCAA	0.403													12	45					0	0	0	0	G	5392414	G	G	5392414	3	3	128	1	0	0	0	0	1	0	0	0	9647	681	24	4	234	4	MIS12	17	5392414	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	881649	5392414	75802796	440	23054											
MFSD6L	162387	broad.mit.edu	37	chr17	8700953	8700953	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actcccgtaaaagtggcctcGgaacaaggcactcagagccc	12	5	10	14	2	1	1	1	0	0	1	3	2	2	2	3	3	2	2	3	3	4	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:8700953G>A	uc002glp.1	-	1	1634	c.1486C>T	c.(1486-1488)CGA>TGA	p.R496*		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	496						integral to membrane				central_nervous_system(1)	1						AAGTGGCCTCGGAACAAGGCA	0.612													9	32					0	0	0	0	A	8700953	A	A	8700953	4	1	128	1	0	0	0	0	0	1	0	0	9589	1124	39	1	278	1	MFSD6L	17	8700953	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3308539	8700953	72494257	441	23055											
NCOR1	9611	broad.mit.edu	37	chr17	15965063	15965063	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttctaacctggcagcttCatgcttactctcttttgttt	5	20	5	11	0	4	0	1	0	3	0	5	0	4	0	1	1	4	4	1	1	2	8			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:15965063C>T	uc002gpo.2	-	37	5773	c.5533G>A	c.(5533-5535)GAA>AAA	p.E1845K	NCOR1_uc002gpn.2_Intron|NCOR1_uc002gpm.2_Missense_Mutation_p.E365K|NCOR1_uc010vwb.1_Missense_Mutation_p.E429K|NCOR1_uc010coy.2_Missense_Mutation_p.E753K|NCOR1_uc010vwc.1_Missense_Mutation_p.E655K	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1845	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTGGCAGCTTCATGCTTACTC	0.507													24	113					0	0	0	0	T	15965063	T	T	15965063	3	4	128	1	0	0	0	0	1	0	0	0	10289	835	29	2	1829	2	NCOR1	17	15965063	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	7264110	15965063	65230147	442	23056											
PEMT	10400	broad.mit.edu	37	chr17	17409126	17409126	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagctcctcttgtgggacccGgaggctttctgccggtagat	5	11	13	12	2	2	1	0	0	2	1	3	3	3	3	3	4	2	3	3	4	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:17409126G>A	uc002grj.2	-	7	646	c.579C>T	c.(577-579)TCC>TCT	p.S193S	PEMT_uc002grk.2_Silent_p.S193S|PEMT_uc002grl.2_Silent_p.S230S|PEMT_uc010vwx.1_3'UTR	NM_148173	NP_680478	Q9UBM1	PEMT_HUMAN	phosphatidylethanolamine N-methyltransferase	193					cell proliferation|phosphatidylcholine biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	phosphatidylethanolamine N-methyltransferase activity				0				Colorectal(2;0.0157)|READ - Rectum adenocarcinoma(2;0.0891)		TGTGGGACCCGGAGGCTTTCT	0.672													4	22					0	0	0	0	A	17409126	A	A	17409126	2	1	128	1	0	0	0	0	0	0	0	1	11780	1103	39	1		1	PEMT	17	17409126	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1444063	17409126	63786084	443	23057											
NLK	51701	broad.mit.edu	37	chr17	26518200	26518200	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcaccaatcccaaatttGatgacactttcgagaagaac	14	10	6	11	1	1	4	1	2	0	2	3	5	2	4	2	0	1	0	2	0	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:26518200G>A	uc010crj.2	+	9	1602	c.1390G>A	c.(1390-1392)GAT>AAT	p.D464N	NLK_uc010cri.1_RNA	NM_016231	NP_057315	Q9UBE8	NLK_HUMAN	nemo like kinase	464					intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		TCCCAAATTTGATGACACTTT	0.428													10	57					0	0	0	0	A	26518200	A	A	26518200	3	1	128	1	0	0	0	0	1	0	0	0	10520	1290	45	2	1424	2	NLK	17	26518200	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	9109074	26518200	54677010	444	23058											
KIAA0100	9703	broad.mit.edu	37	chr17	26943185	26943185	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgttcatggcagctcgctCtttcatcttgtcaatgtcat	6	17	8	10	1	6	0	4	0	2	0	7	0	6	0	0	1	1	5	0	1	1	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:26943185C>T	uc002hbu.2	-	37	6418	c.6319G>A	c.(6319-6321)GAG>AAG	p.E2107K	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_Intron|KIAA0100_uc002hbt.2_Missense_Mutation_p.E436K	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2107						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GCAGCTCGCTCTTTCATCTTG	0.483													4	56					0	0	0	0	T	26943185	T	T	26943185	3	4	128	1	0	0	0	0	1	0	0	0	8193	922	32	2	400	2	KIAA0100	17	26943185	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	424985	26943185	54252025	445	23059											
ATAD5	79915	broad.mit.edu	37	chr17	29161435	29161435	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaatgtagagtttaagaaGaaaagaaagagggttaattt	19	11	10	1	0	1	5	1	0	0	5	1	5	1	5	0	1	0	3	0	1	8	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29161435G>C	uc002hfs.1	+	2	682	c.336G>C	c.(334-336)AAG>AAC	p.K112N	ATAD5_uc002hft.1_Missense_Mutation_p.K9N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	112					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGTTTAAGAAGAAAAGAAAGA	0.338													15	136					0	0	0	0	C	29161435	C	C	29161435	3	2	128	1	0	0	0	0	1	0	0	0	1078	933	33	2	342	2	ATAD5	17	29161435	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2218250	29161435	52033775	446	23060			1	30		10	10	2851	G		6.371905e-18
ATAD5	79915	broad.mit.edu	37	chr17	29161585	29161585	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttctgttttacgttacaaGaaacaagtagaggtacttgc	13	13	8	7	1	1	2	0	0	1	2	1	2	1	2	0	1	5	4	0	1	7	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29161585G>C	uc002hfs.1	+	2	832	c.486G>C	c.(484-486)AAG>AAC	p.K162N	ATAD5_uc002hft.1_Missense_Mutation_p.K59N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	162					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TACGTTACAAGAAACAAGTAG	0.313													16	197					0	0	0	0	C	29161585	C	C	29161585	3	2	128	1	0	0	0	0	1	0	0	0	1078	933	33	2	492	2	ATAD5	17	29161585	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	150	29161585	52033625	447	23061			1	30		10	10	2851	G		6.371905e-18
ATAD5	79915	broad.mit.edu	37	chr17	29161714	29161714	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaatgacttcaaaaagttGagaaaaaggaaatgcagaga	23	6	9	3	0	1	3	1	2	0	2	1	6	1	4	0	1	1	2	0	1	7	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29161714G>C	uc002hfs.1	+	2	961	c.615G>C	c.(613-615)TTG>TTC	p.L205F	ATAD5_uc002hft.1_Missense_Mutation_p.L102F	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	205					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TCAAAAAGTTGAGAAAAAGGA	0.328													23	141					0	0	0	0	C	29161714	C	C	29161714	3	2	128	1	0	0	0	0	1	0	0	0	1078	1281	45	2	621	2	ATAD5	17	29161714	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	129	29161714	52033496	448	23062			1	30		10	10	2851	G		6.371905e-18
ATAD5	79915	broad.mit.edu	37	chr17	29161793	29161793	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactaaatttgcttaaaaaaGatggtaaagatactaaacag	21	10	6	4	0	0	2	0	0	0	2	0	2	0	2	0	1	4	2	0	1	11	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29161793G>C	uc002hfs.1	+	2	1040	c.694G>C	c.(694-696)GAT>CAT	p.D232H	ATAD5_uc002hft.1_Missense_Mutation_p.D129H	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	232					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GCTTAAAAAAGATGGTAAAGA	0.338													16	126					0	0	0	0	C	29161793	C	C	29161793	3	2	128	1	0	0	0	0	1	0	0	0	1078	942	33	2	700	2	ATAD5	17	29161793	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	79	29161793	52033417	449	23063			1	30		10	10	2851	G		6.371905e-18
ATAD5	79915	broad.mit.edu	37	chr17	29162131	29162131	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaataccccgaattttcttGaaacaaaagcaatttgaaat	19	11	4	7	1	1	2	0	2	1	0	1	3	1	2	2	0	3	1	2	0	9	5	rs111343309	by1000genomes	TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29162131G>A	uc002hfs.1	+	2	1378	c.1032G>A	c.(1030-1032)TTG>TTA	p.L344L	ATAD5_uc002hft.1_Silent_p.L241L	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	344					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GAATTTTCTTGAAACAAAAGC	0.378													9	42					0	0	0	0	A	29162131	A	A	29162131	2	1	128	1	0	0	0	0	0	0	0	1	1078	1281	45	2		2	ATAD5	17	29162131	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	338	29162131	52033079	450	23064			1	30		10	10	2851	G		6.371905e-18
ATAD5	79915	broad.mit.edu	37	chr17	29162199	29162199	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaacagacagttcagaaaaGaaaatctaatgttgttatac	18	11	7	5	0	2	4	1	1	1	3	2	4	2	4	0	0	2	3	0	0	8	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29162199G>C	uc002hfs.1	+	2	1446	c.1100G>C	c.(1099-1101)AGA>ACA	p.R367T	ATAD5_uc002hft.1_Missense_Mutation_p.R264T	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	367					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GTTCAGAAAAGAAAATCTAAT	0.343													11	50					0	0	0	0	C	29162199	C	C	29162199	3	2	128	1	0	0	0	0	1	0	0	0	1078	942	33	2	1106	2	ATAD5	17	29162199	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	68	29162199	52033011	451	23065			1	30		10	10	2851	G		6.371905e-18
ATAD5	79915	broad.mit.edu	37	chr17	29162272	29162272	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctggaagttctgaagctgtGaaaccaaaatgcactctaga	14	9	10	8	0	2	3	0	2	2	1	2	4	2	4	1	1	3	4	1	1	6	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29162272G>A	uc002hfs.1	+	2	1519	c.1173G>A	c.(1171-1173)GTG>GTA	p.V391V	ATAD5_uc002hft.1_Silent_p.V288V	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	391					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				CTGAAGCTGTGAAACCAAAAT	0.363													15	72					0	0	0	0	A	29162272	A	A	29162272	2	1	128	1	0	0	0	0	0	0	0	1	1078	1277	45	2		2	ATAD5	17	29162272	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	73	29162272	52032938	452	23066			1	30		10	10	2851	G		6.371905e-18
ATAD5	79915	broad.mit.edu	37	chr17	29162420	29162420	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatatgaagtaggaagagatGataattctaaaaaaatcatg	20	11	8	2	0	2	3	1	2	1	1	2	5	2	4	0	1	0	1	0	1	10	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29162420G>A	uc002hfs.1	+	2	1667	c.1321G>A	c.(1321-1323)GAT>AAT	p.D441N	ATAD5_uc002hft.1_Missense_Mutation_p.D338N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	441					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGGAAGAGATGATAATTCTAA	0.323													10	63					0	0	0	0	A	29162420	A	A	29162420	3	1	128	1	0	0	0	0	1	0	0	0	1078	1290	45	2	1327	2	ATAD5	17	29162420	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	148	29162420	52032790	453	23067			1	30		10	10	2851	G		6.371905e-18
ATAD5	79915	broad.mit.edu	37	chr17	29162726	29162726	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaaagtcttgtttatgaaGatatagcaaatgatgacctt	15	14	8	4	0	1	5	0	4	1	1	1	5	1	5	1	0	1	2	1	0	6	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29162726G>A	uc002hfs.1	+	2	1973	c.1627G>A	c.(1627-1629)GAT>AAT	p.D543N	ATAD5_uc002hft.1_Missense_Mutation_p.D440N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	543					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TGTTTATGAAGATATAGCAAA	0.289													20	70					0	0	0	0	A	29162726	A	A	29162726	3	1	128	1	0	0	0	0	1	0	0	0	1078	942	33	2	1633	2	ATAD5	17	29162726	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	306	29162726	52032484	454	23068			1	30		10	10	2851	G		6.371905e-18
ATAD5	79915	broad.mit.edu	37	chr17	29164285	29164285	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaatctaacaaaagatctGagaaatctgaagcaactgat	21	8	6	6	0	3	4	0	3	3	2	3	5	3	4	0	0	3	1	0	0	8	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29164285G>A	uc002hfs.1	+	3	2375	c.2029G>A	c.(2029-2031)GAG>AAG	p.E677K	ATAD5_uc002hft.1_Missense_Mutation_p.E574K	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	677					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				caaaagatctgagaaaTCTGA	0.249													11	51					0	0	0	0	A	29164285	A	A	29164285	3	1	128	1	0	0	0	0	1	0	0	0	1078	1291	45	2	2039	2	ATAD5	17	29164285	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1559	29164285	52030925	455	23069			1	30		10	10	2851	G		6.371905e-18
LRRC37B	114659	broad.mit.edu	37	chr17	30349317	30349317	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaccttcttctacagccctGaggactacagatcctcctcc	9	10	6	16	0	2	2	0	1	2	1	5	4	5	3	5	1	4	0	5	1	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:30349317G>A	uc002hgu.2	+	1	1163	c.1152G>A	c.(1150-1152)CTG>CTA	p.L384L	LRRC37B_uc010wbx.1_Silent_p.L302L|LRRC37B_uc010csu.2_Silent_p.L384L	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	384	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				CTACAGCCCTGAGGACTACAG	0.542													33	193					0	0	0	0	A	30349317	A	A	30349317	2	1	128	1	0	0	0	0	0	0	0	1	9044	1277	45	2		2	LRRC37B	17	30349317	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1185032	30349317	50845893	456	23070											
LRRC37B	114659	broad.mit.edu	37	chr17	30376174	30376174	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacggtccctcatccccaacGaggatgtgagaaagttcatg	11	9	10	11	2	2	1	2	1	0	1	4	4	4	2	3	2	2	1	3	2	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:30376174G>A	uc002hgu.2	+	10	2448	c.2437G>A	c.(2437-2439)GAG>AAG	p.E813K	LRRC37B_uc010wbx.1_Missense_Mutation_p.E731K|LRRC37B_uc010csu.2_Missense_Mutation_p.E762K	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	813	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				CATCCCCAACGAGGATGTGAG	0.498													22	105					0	0	0	0	A	30376174	A	A	30376174	3	1	128	1	0	0	0	0	1	0	0	0	9044	1059	37	1	2475	1	LRRC37B	17	30376174	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	26857	30376174	50819036	457	23071											
SRCIN1	80725	broad.mit.edu	37	chr17	36704795	36704795	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtgtgccctgacctacctCtagctctgcgatgatgcgat	7	11	11	12	2	2	2	0	2	2	0	2	4	2	2	3	1	5	1	3	1	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:36704795C>G	uc002hqd.2	-	17	3493	c.3268G>C	c.(3268-3270)GAG>CAG	p.E1090Q	SRCIN1_uc002hqf.1_Missense_Mutation_p.E962Q|SRCIN1_uc002hqe.2_Missense_Mutation_p.E944Q	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	962					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						TGACCTACCTCTAGCTCTGCG	0.662													11	58					0	0	0	0	G	36704795	G	G	36704795	3	3	128	1	0	0	0	0	1	0	0	0	15202	922	32	2	295	2	SRCIN1	17	36704795	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	6328621	36704795	44490415	458	23072											
SRCIN1	80725	broad.mit.edu	37	chr17	36704826	36704826	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatgcgatcctcgtcatcCtcgtccttgatggccgaggc	6	11	11	13	4	1	2	1	2	0	0	6	4	4	2	4	2	1	0	4	2	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:36704826C>T	uc002hqd.2	-	17	3462	c.3237G>A	c.(3235-3237)GAG>GAA	p.E1079E	SRCIN1_uc002hqf.1_Silent_p.E951E|SRCIN1_uc002hqe.2_Silent_p.E933E	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	951					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						CCTCGTCATCCTCGTCCTTGA	0.667													11	59					0	0	0	0	T	36704826	T	T	36704826	2	4	128	1	0	0	0	0	0	0	0	1	15202	680	24	4		4	SRCIN1	17	36704826	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	31	36704826	44490384	459	23073											
MLLT6	4302	broad.mit.edu	37	chr17	36876644	36876644	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcgtggagatgctgaaggcGctgcacgcgctgcagaagga	9	6	17	9	4	0	3	0	1	0	2	1	5	0	4	0	3	3	5	0	3	2	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:36876644G>C	uc002hqi.3	+	15	2188	c.2175G>C	c.(2173-2175)GCG>GCC	p.A725A	MLLT6_uc002hqj.2_Silent_p.A160A|MLLT6_uc002hqk.3_Silent_p.A56A	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	725					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					TGCTGAAGGCGCTGCACGCGC	0.433			T	MLL	AL								4	24					0	0	0	0	C	36876644	C	C	36876644	2	2	128	1	0	0	0	0	0	0	0	1	9683	1074	38	3		3	MLLT6	17	36876644	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	171818	36876644	44318566	460	23074											
PNMT	5409	broad.mit.edu	37	chr17	37826388	37826388	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccagctttcagcgggccctgGaccacatcaccacgctgctg	7	7	10	17	2	2	0	2	0	0	0	2	1	2	1	4	2	3	3	4	2	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:37826388G>C	uc002hsi.1	+	3	817	c.595G>C	c.(595-597)GAC>CAC	p.D199H		NM_002686	NP_002677	P11086	PNMT_HUMAN	phenylethanolamine N-methyltransferase	199					catecholamine biosynthetic process|hormone biosynthetic process	cytosol	phenylethanolamine N-methyltransferase activity			ovary(1)	1	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GCGGGCCCTGGACCACATCAC	0.682													6	40					0	0	0	0	C	37826388	C	C	37826388	3	2	128	1	0	0	0	0	1	0	0	0	12214	1174	41	2	605	2	PNMT	17	37826388	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	949744	37826388	43368822	461	23075											
GRB7	2886	broad.mit.edu	37	chr17	37900456	37900456	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttactccaccaagggcacctCtaaggtaaggtcttgagggt	10	10	11	10	0	2	1	0	1	2	0	3	1	3	1	3	4	1	2	3	4	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:37900456C>A	uc002hsr.2	+	7	1047	c.797C>A	c.(796-798)TCT>TAT	p.S266Y	GRB7_uc002hss.2_Missense_Mutation_p.S266Y|GRB7_uc010cwc.2_Missense_Mutation_p.S266Y|GRB7_uc002hst.2_Missense_Mutation_p.S266Y	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	266	PH.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			AAGGGCACCTCTAAGGTAAGG	0.572													17	186					5.03518e-11	5.36816e-11	1	0	A	37900456	A	A	37900456	3	1	128	1	0	0	0	0	1	0	0	0	6798	913	32	2	819	2	GRB7	17	37900456	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	74068	37900456	43294754	462	23076											
RAPGEFL1	51195	broad.mit.edu	37	chr17	38348898	38348898	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aagctaccgagaagtgatctCcaaaatgaagccccctgtga	14	7	9	11	1	1	4	0	3	1	1	2	5	1	4	4	0	3	1	4	0	6	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:38348898C>A	uc010cwu.1	+	12	1569	c.1079C>A	c.(1078-1080)TCC>TAC	p.S360Y	RAPGEFL1_uc010wfd.1_Missense_Mutation_p.S296Y	NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor	566	Ras-GEF.				G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GAAGTGATCTCCAAAATGAAG	0.527													38	233					4.67007e-22	5.05223e-22	1	0	A	38348898	A	A	38348898	3	1	128	1	0	0	0	0	1	0	0	0	13114	855	30	2	1117	2	RAPGEFL1	17	38348898	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	448442	38348898	42846312	463	23077											
CCDC56	28958	broad.mit.edu	37	chr17	40948652	40948652	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atggtacctggctgcagcttCgccttcctcccaccttggag	5	11	10	15	1	0	0	0	0	0	0	3	1	2	1	5	3	3	4	5	3	1	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:40948652C>T	uc010wgz.1	-	2	350	c.73G>A	c.(73-75)GAA>AAA	p.E25K	WNK4_uc002ibj.2_Intron|WNK4_uc010wgx.1_Intron|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank			Q9Y2R0	CCD56_HUMAN	SubName: Full=cDNA FLJ50764;	Error:Variant_position_missing_in_Q9Y2R0_after_alignment						integral to membrane					0		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0741)		GCTGCAGCTTCGCCTTCCTCC	0.587													16	69					0	0	0	0	T	40948652	T	T	40948652	3	4	128	1	0	0	0	0	1	0	0	0	2839	899	31	1		1	CCDC56	17	40948652	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2599754	40948652	40246558	464	23078											
TMEM101	84336	broad.mit.edu	37	chr17	42092252	42092252	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccaaaaggggcagcgtgtGagcagcaccgaacccaactg	12	3	12	14	2	0	1	0	1	0	0	0	2	0	1	4	2	5	3	4	2	4	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:42092252G>A	uc002ieu.2	-	1	94	c.69C>T	c.(67-69)CTC>CTT	p.L23L	TMEM101_uc010wis.1_Intron	NM_032376	NP_115752	Q96IK0	TM101_HUMAN	transmembrane protein 101	23	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		Breast(137;0.0264)|Prostate(33;0.0861)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GGCAGCGTGTGAGCAGCACCG	0.627													22	63					0	0	0	0	A	42092252	A	A	42092252	2	1	128	1	0	0	0	0	0	0	0	1	16082	1277	45	2		2	TMEM101	17	42092252	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1143600	42092252	39102958	465	23079											
G6PC3	92579	broad.mit.edu	37	chr17	42153206	42153206	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggtgcgtcgggcacagctggGaaatggccagaagatagcct	10	6	16	9	2	0	2	0	0	0	2	1	3	0	3	2	4	3	2	2	4	3	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:42153206G>A	uc002iex.2	+	6	1052	c.836G>A	c.(835-837)GGA>GAA	p.G279E	G6PC3_uc002iey.2_Missense_Mutation_p.G154E|G6PC3_uc010czo.2_Missense_Mutation_p.G135E|G6PC3_uc002iez.2_Missense_Mutation_p.G154E|G6PC3_uc002ifb.2_Missense_Mutation_p.G154E|G6PC3_uc002ifc.2_Missense_Mutation_p.G88E	NM_138387	NP_612396	Q9BUM1	G6PC3_HUMAN	glucose-6-phosphatase catalytic subunit 3	279	Cytoplasmic (Potential).				gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			skin(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GCACAGCTGGGAAATGGCCAG	0.652													12	52					0	0	0	0	A	42153206	A	A	42153206	3	1	128	1	0	0	0	0	1	0	0	0	6179	1174	41	2	858	2	G6PC3	17	42153206	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	60954	42153206	39042004	466	23080											
NMT1	4836	broad.mit.edu	37	chr17	43171126	43171126	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caggagccctacaccctgccCcagggcttcacctgggatgc	7	6	11	17	0	1	0	1	0	0	0	1	2	1	2	5	3	4	1	5	3	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:43171126C>G	uc002ihz.2	+	4	477	c.459C>G	c.(457-459)CCC>CCG	p.P153P	NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	153					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				ACACCCTGCCCCAGGGCTTCA	0.597													9	54					0	0	0	0	G	43171126	G	G	43171126	2	3	128	1	0	0	0	0	0	0	0	1	10557	610	22	4		4	NMT1	17	43171126	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1017920	43171126	38024084	467	23081											
COPZ2	51226	broad.mit.edu	37	chr17	46111232	46111232	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagagggggacacttactctCagtccggctggtcttgttga	8	11	13	9	1	2	2	1	1	2	1	4	3	3	3	1	4	1	2	1	4	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:46111232C>T	uc002imy.2	-	7	278	c.265G>A	c.(265-267)GAG>AAG	p.E89K		NM_016429	NP_057513	Q9P299	COPZ2_HUMAN	coatomer protein complex, subunit zeta 2	89					intracellular protein transport|vesicle-mediated transport	cis-Golgi network|COPI vesicle coat					0						CACTTACTCTCAGTCCGGCTG	0.483													3	20					0	0	0	0	T	46111232	T	T	46111232	3	4	128	1	0	0	0	0	1	0	0	0	3757	835	29	2	395	2	COPZ2	17	46111232	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2940106	46111232	35083978	468	23082											
HOXB8	3218	broad.mit.edu	37	chr17	46690757	46690757	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgtcagtcccagggcgtgcGatacctcgattcgccgctta	6	10	11	14	5	1	0	1	0	0	0	4	2	2	0	3	1	2	1	3	1	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:46690757G>C	uc002inw.2	-	2	774	c.539C>G	c.(538-540)TCG>TGG	p.S180W	HOXB7_uc002inv.2_5'Flank	NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	180	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CAGGGCGTGCGATACCTCGAT	0.532													11	93					0	0	0	0	C	46690757	C	C	46690757	3	2	128	1	0	0	0	0	1	0	0	0	7346	1059	37	3	196	3	HOXB8	17	46690757	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	579525	46690757	34504453	469	23083											
MYST2	11143	broad.mit.edu	37	chr17	47886529	47886529	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagaagaaaggatgctgtctCacaggcaagatgacaacaac	17	6	10	8	0	1	4	1	1	1	3	2	5	1	5	0	2	3	2	0	2	6	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:47886529C>G	uc002ipm.2	+	6	838	c.712C>G	c.(712-714)CAC>GAC	p.H238D	MYST2_uc002ipl.1_Intron|MYST2_uc010wma.1_Missense_Mutation_p.H99D|MYST2_uc010wmb.1_Intron|MYST2_uc010wmc.1_Intron|MYST2_uc010wmd.1_Missense_Mutation_p.H82D|MYST2_uc010wme.1_Intron	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	238					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GATGCTGTCTCACAGGCAAGA	0.478													10	49					0	0	0	0	G	47886529	G	G	47886529	3	3	128	1	0	0	0	0	1	0	0	0	10156	826	29	2	734	2	MYST2	17	47886529	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1195772	47886529	33308681	470	23084											
USP32	84669	broad.mit.edu	37	chr17	58282903	58282903	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatttgtgaagttcttctCagttccacatggcacaacag	10	13	7	11	0	2	1	1	1	2	0	5	1	4	1	2	1	1	3	2	1	2	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:58282903C>T	uc002iyo.1	-	26	3440	c.3154G>A	c.(3154-3156)GAG>AAG	p.E1052K	USP32_uc002iyn.1_Missense_Mutation_p.E722K	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1052					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AAGTTCTTCTCAGTTCCACAT	0.443													11	78					0	0	0	0	T	58282903	T	T	58282903	3	4	128	1	0	0	0	0	1	0	0	0	17131	835	29	2	1696	2	USP32	17	58282903	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	10396374	58282903	22912307	471	23085											
TLK2	11011	broad.mit.edu	37	chr17	60598187	60598187	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtgcagcgtcggatccttGagtgataaagaagtagaggt	11	11	14	5	2	0	4	0	2	0	2	2	5	1	5	1	2	2	2	1	2	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:60598187G>C	uc010ddp.2	+	3	403	c.135G>C	c.(133-135)TTG>TTC	p.L45F	TLK2_uc002izx.3_5'UTR|TLK2_uc002izz.3_Missense_Mutation_p.L45F|TLK2_uc002jaa.3_Missense_Mutation_p.L45F|TLK2_uc010wpd.1_Missense_Mutation_p.L45F	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	45					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						TCGGATCCTTGAGTGATAAAG	0.299													12	79					0	0	0	0	C	60598187	C	C	60598187	3	2	128	1	0	0	0	0	1	0	0	0	16010	1281	45	2	141	2	TLK2	17	60598187	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2315284	60598187	20597023	472	23086											
LIMD2	80774	broad.mit.edu	37	chr17	61776232	61776232	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttgtcggccaccagccgctCcatggggtacacggtcttct	5	10	11	15	3	2	0	0	0	2	0	4	0	3	0	4	4	2	2	4	4	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:61776232C>T	uc002jbj.3	-	4	329	c.151G>A	c.(151-153)GAG>AAG	p.E51K	LIMD2_uc002jbk.3_Missense_Mutation_p.G52E|LIMD2_uc002jbl.3_Missense_Mutation_p.E51K	NM_030576	NP_085053	Q9BT23	LIMD2_HUMAN	LIM domain containing 2	51	LIM zinc-binding.						zinc ion binding				0						ACCAGCCGCTCCATGGGGTAC	0.562													12	74					0	0	0	0	T	61776232	T	T	61776232	3	4	128	1	0	0	0	0	1	0	0	0	8840	864	30	2	240	2	LIMD2	17	61776232	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1178045	61776232	19418978	473	23087											
PRKCA	5578	broad.mit.edu	37	chr17	64683318	64683318	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttattcctgatcccaagaatGaaagcaagcaaaaaaccaaa	20	7	5	9	0	0	3	0	2	0	1	2	3	2	3	3	0	3	2	3	0	9	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:64683318G>A	uc002jfp.1	+	6	663	c.619G>A	c.(619-621)GAA>AAA	p.E207K	PRKCA_uc002jfo.1_Missense_Mutation_p.E78K	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	207	C2.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	TCCCAAGAATGAAAGCAAGCA	0.408													27	127					0	0	0	0	A	64683318	A	A	64683318	3	1	128	1	0	0	0	0	1	0	0	0	12569	1291	45	2	641	2	PRKCA	17	64683318	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2907086	64683318	16511892	474	23088											
HELZ	9931	broad.mit.edu	37	chr17	65147302	65147302	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacagtactgatgcacaactGggtggacagtctttacccag	12	9	10	10	0	1	1	0	1	1	0	1	2	1	2	1	2	5	2	1	2	4	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:65147302G>A	uc010wqk.1	-	18	2406	c.2219C>T	c.(2218-2220)CCA>CTA	p.P740L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.P739L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					ATGCACAACTGGGTGGACAGT	0.373													21	87					0	0	0	0	A	65147302	A	A	65147302	3	1	128	1	0	0	0	0	1	0	0	0	7088	1348	47	4	3676	4	HELZ	17	65147302	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	463984	65147302	16047908	475	23089											
KPNA2	3838	broad.mit.edu	37	chr17	66039309	66039309	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgctgttgagcagattcttCctaccttagttcggctcctg	6	15	9	11	1	1	2	0	1	1	1	4	2	3	2	3	1	3	5	3	1	2	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:66039309C>T	uc002jgk.2	+	7	892	c.760C>T	c.(760-762)CCT>TCT	p.P254S	KPNA2_uc002jgl.2_Missense_Mutation_p.P254S	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	254	ARM 5.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GCAGATTCTTCCTACCTTAGT	0.468													49	291					0	0	0	0	T	66039309	T	T	66039309	3	4	128	1	0	0	0	0	1	0	0	0	8469	855	30	2	782	2	KPNA2	17	66039309	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	892007	66039309	15155901	476	23090											
KPNA2	3838	broad.mit.edu	37	chr17	66042035	66042035	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgagaagtatttctctgtaGaggtgagtaatggatggtaa	12	14	13	2	0	1	3	0	2	1	2	2	5	1	4	0	3	0	4	0	3	5	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:66042035G>A	uc002jgk.2	+	10	1627	c.1495G>A	c.(1495-1497)GAG>AAG	p.E499K	KPNA2_uc002jgl.2_Missense_Mutation_p.E499K	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	499	Poly-Glu.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTTCTCTGTAGAGGTGAGTAA	0.328													23	102					0	0	0	0	A	66042035	A	A	66042035	3	1	128	1	0	0	0	0	1	0	0	0	8469	943	33	2	1529	2	KPNA2	17	66042035	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2726	66042035	15153175	477	23091											
GGA3	23163	broad.mit.edu	37	chr17	73237033	73237033	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagggaggattgggatgcctGaggagggtggagtaggtgct	8	8	22	3	0	0	1	0	1	0	0	0	7	0	6	1	7	2	2	1	7	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:73237033G>A	uc002jni.1	-	11	1061	c.1052C>T	c.(1051-1053)TCA>TTA	p.S351L	GGA3_uc002jnj.1_Missense_Mutation_p.S318L|GGA3_uc010wrw.1_Missense_Mutation_p.S229L|GGA3_uc002jnk.1_Missense_Mutation_p.S279L|GGA3_uc010wrx.1_Missense_Mutation_p.S229L|GGA3_uc010wry.1_Missense_Mutation_p.S279L	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	351	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			TGGGATGCCTGAGGAGGGTGG	0.647											OREG0024730	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	56					0	0	0	0	A	73237033	A	A	73237033	3	1	128	1	0	0	0	0	1	0	0	0	6391	1294	45	2	1235	2	GGA3	17	73237033	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7194998	73237033	7958177	478	23092											
TRIM65	201292	broad.mit.edu	37	chr17	73887415	73887415	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgctgactggatcaaaggtCagattgcgataatctgttgg	10	11	13	7	2	3	2	2	1	1	1	3	4	3	3	0	3	1	2	0	3	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:73887415C>T	uc002jpx.2	-	6	1035	c.999G>A	c.(997-999)CTG>CTA	p.L333L		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	333	B30.2/SPRY.					intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			GATCAAAGGTCAGATTGCGAT	0.498													8	19					0	0	0	0	T	73887415	T	T	73887415	2	4	128	1	0	0	0	0	0	0	0	1	16606	813	29	2		2	TRIM65	17	73887415	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	650382	73887415	7307795	479	23093											
TNRC6C	57690	broad.mit.edu	37	chr17	76045388	76045388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactatgattggagatgggaGaagtcagaattgctggggtg	11	10	16	4	0	1	4	1	1	0	3	1	6	1	4	0	4	1	1	0	4	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:76045388G>A	uc002jud.2	+	4	845	c.245G>A	c.(244-246)AGA>AAA	p.R82K	TNRC6C_uc002juf.2_Missense_Mutation_p.R82K|TNRC6C_uc002jue.2_Missense_Mutation_p.R82K	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	82	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GGAGATGGGAGAAGTCAGAAT	0.522													15	79					0	0	0	0	A	76045388	A	A	76045388	3	1	128	1	0	0	0	0	1	0	0	0	16408	942	33	2	247	2	TNRC6C	17	76045388	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2157973	76045388	5149822	480	23094											
LGALS3BP	3959	broad.mit.edu	37	chr17	76967746	76967746	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgccgggcaggggaaggagGaggtgctcttcgagctgttg	6	8	19	8	2	1	0	0	0	1	0	2	4	1	3	1	6	3	4	1	6	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:76967746G>A	uc002jwh.2	-	6	1849	c.1670C>T	c.(1669-1671)TCC>TTC	p.S557F	LGALS3BP_uc002jwi.2_Missense_Mutation_p.S363F|LGALS3BP_uc010dhr.2_Missense_Mutation_p.S363F	NM_005567	NP_005558	Q08380	LG3BP_HUMAN	galectin 3 binding protein	557					cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			central_nervous_system(3)|ovary(1)	4			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			GGGGAAGGAGGAGGTGCTCTT	0.632											OREG0024787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	55					0	0	0	0	A	76967746	A	A	76967746	3	1	128	1	0	0	0	0	1	0	0	0	8784	1174	41	2	91	2	LGALS3BP	17	76967746	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	922358	76967746	4227464	481	23095											
CARD14	79092	broad.mit.edu	37	chr17	78156549	78156549	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgacgtctacaccctggtCaccgggctgcagcctgatgt	6	9	11	15	2	2	2	1	2	1	0	2	2	2	2	4	2	3	2	4	2	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:78156549C>T	uc002jxw.1	+	3	504	c.309C>T	c.(307-309)GTC>GTT	p.V103V	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Silent_p.V103V|CARD14_uc010wud.1_5'Flank	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	103	CARD.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			ACACCCTGGTCACCGGGCTGC	0.557													8	35					0	0	0	0	T	78156549	T	T	78156549	2	4	128	1	0	0	0	0	0	0	0	1	2658	813	29	2		2	CARD14	17	78156549	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1188803	78156549	3038661	482	23096											
RNF213	57674	broad.mit.edu	37	chr17	78320513	78320513	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagggcccggctgcctactCagatctcttccgcagcctga	6	8	11	16	2	2	2	1	1	1	1	4	2	3	2	4	2	3	3	4	2	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:78320513C>G	uc002jyh.1	+	4	2820	c.2597C>G	c.(2596-2598)TCA>TGA	p.S866*		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GCTGCCTACTCAGATCTCTTC	0.642													4	11					0	0	0	0	G	78320513	G	G	78320513	4	3	128	1	0	0	0	0	0	1	0	0	13542	838	29	2	8807	2	RNF213	17	78320513	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	163964	78320513	2874697	483	23097											
FN3KRP	79672	broad.mit.edu	37	chr17	80674690	80674690	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcagggccacgggccactCggggggcgggtgcatcagcc	5	5	18	13	3	2	0	2	0	0	0	3	0	2	0	3	6	2	1	3	6	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:80674690C>A	uc002kfu.2	+	1	109	c.59C>A	c.(58-60)TCG>TAG	p.S20*	FN3KRP_uc010wvr.1_5'UTR	NM_024619	NP_078895	Q9HA64	KT3K_HUMAN	fructosamine 3 kinase related protein	20							kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			ACGGGCCACTCGGGGGGCGGG	0.706													5	19					0.00116845	0.00119189	1	0	A	80674690	A	A	80674690	4	1	128	1	0	0	0	0	0	1	0	0	5996	893	31	3	61	3	FN3KRP	17	80674690	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2354177	80674690	520520	484	23098											
ZNF750	79755	broad.mit.edu	37	chr17	80788498	80788498	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgaccggggaaggcaggcctCggagcctgggtgttacaggg	7	5	19	10	3	0	0	0	0	0	0	1	3	0	2	3	7	2	2	3	7	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:80788498C>T	uc002kga.2	-	3	2003	c.1692G>A	c.(1690-1692)CCG>CCA	p.P564P	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	564						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGGCAGGCCTCGGAGCCTGGG	0.627													14	57					0	0	0	0	T	80788498	T	T	80788498	2	4	128	1	0	0	0	0	0	0	0	1	18199	871	31	1		1	ZNF750	17	80788498	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	113808	80788498	406712	485	23099											
ZNF750	79755	broad.mit.edu	37	chr17	80789280	80789280	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagaccagggtggcttcttCaagcaggtgagagctctgat	10	10	13	8	0	3	3	1	2	2	2	3	4	3	3	1	3	2	3	1	3	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:80789280C>T	uc002kga.2	-	2	1362	c.1051G>A	c.(1051-1053)GAA>AAA	p.E351K	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	351						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GTGGCTTCTTCAAGCAGGTGA	0.532													32	129					0	0	0	0	T	80789280	T	T	80789280	3	4	128	1	0	0	0	0	1	0	0	0	18199	835	29	2	1128	2	ZNF750	17	80789280	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	782	80789280	405930	486	23100											
ZNF750	79755	broad.mit.edu	37	chr17	80790150	80790150	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttagggcacttgggaactcGatcctgctctgatactaaag	10	12	10	9	1	1	1	0	1	1	0	3	3	2	2	1	2	3	2	1	2	5	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:80790150G>A	uc002kga.2	-	2	492	c.181C>T	c.(181-183)CGA>TGA	p.R61*	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	61						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TTGGGAACTCGATCCTGCTCT	0.448													15	63					0	0	0	0	A	80790150	A	A	80790150	4	1	128	1	0	0	0	0	0	1	0	0	18199	1066	37	1	1998	1	ZNF750	17	80790150	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	870	80790150	405060	487	23101											
CLUL1	27098	broad.mit.edu	37	chr18	627346	627346	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatcagatacagacctaactGagccttacttttttccagct	11	14	5	11	0	1	3	1	1	0	2	2	3	2	3	3	0	5	1	3	0	4	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:627346G>A	uc002kkp.2	+	5	818	c.673G>A	c.(673-675)GAG>AAG	p.E225K	CLUL1_uc010wys.1_Missense_Mutation_p.E277K|CLUL1_uc002kkq.2_Missense_Mutation_p.E225K	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	225					cell death	extracellular region				ovary(2)	2						AGACCTAACTGAGCCTTACTT	0.388													16	115					0	0	0	0	A	627346	A	A	627346	3	1	128	1	0	0	0	0	1	0	0	0	3585	1291	45	2	687	2	CLUL1	18	627346	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08		627346	77449902	488	23102											
KIAA0802	23255	broad.mit.edu	37	chr18	8796233	8796233	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctcttattccattcaagatgGaggaggagcacctctatgcc	10	11	9	11	0	3	1	1	0	2	1	4	4	4	4	3	3	2	1	3	3	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:8796233G>C	uc002knr.2	+	9	2156	c.2014G>C	c.(2014-2016)GAG>CAG	p.E672Q	KIAA0802_uc002knq.2_Missense_Mutation_p.E631Q|KIAA0802_uc002kns.2_Missense_Mutation_p.E2Q	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	982											0						ATTCAAGATGGAGGAGGAGCA	0.498													10	87					0	0	0	0	C	8796233	C	C	8796233	3	2	128	1	0	0	0	0	1	0	0	0	8233	1175	41	2	2040	2	KIAA0802	18	8796233	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	8168887	8796233	69281015	489	23103											
KIAA0802	23255	broad.mit.edu	37	chr18	8796331	8796331	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaacctggagtgatgagaaGaatctgatgcagcaggagct	13	7	14	7	1	1	4	0	3	1	2	1	8	1	6	1	2	4	3	1	2	3	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:8796331G>C	uc002knr.2	+	9	2254	c.2112G>C	c.(2110-2112)AAG>AAC	p.K704N	KIAA0802_uc002knq.2_Missense_Mutation_p.K663N|KIAA0802_uc002kns.2_Missense_Mutation_p.K34N	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1014											0						GTGATGAGAAGAATCTGATGC	0.522													12	80					0	0	0	0	C	8796331	C	C	8796331	3	2	128	1	0	0	0	0	1	0	0	0	8233	933	33	2	2138	2	KIAA0802	18	8796331	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	98	8796331	69280917	490	23104											
ASXL3	80816	broad.mit.edu	37	chr18	31324832	31324832	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtgaaatctgaacttcacGaagcagacaagggctttaga	14	9	10	8	1	2	4	1	2	1	2	2	5	2	4	0	1	2	2	0	1	5	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:31324832G>A	uc010dmg.1	+	12	5075	c.5020G>A	c.(5020-5022)GAA>AAA	p.E1674K	ASXL3_uc002kxq.2_Missense_Mutation_p.E1381K	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1674					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TGAACTTCACGAAGCAGACAA	0.478													12	63					0	0	0	0	A	31324832	A	A	31324832	3	1	128	1	0	0	0	0	1	0	0	0	1070	1059	37	1	5066	1	ASXL3	18	31324832	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	22528501	31324832	46752416	491	23105											
ASXL3	80816	broad.mit.edu	37	chr18	31325319	31325319	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagagtagctaggactgtagGagaacacactcaagttaaat	16	8	11	6	0	1	2	1	0	0	2	1	5	1	3	0	2	2	4	0	2	7	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:31325319G>A	uc010dmg.1	+	12	5562	c.5507G>A	c.(5506-5508)GGA>GAA	p.G1836E	ASXL3_uc002kxq.2_Missense_Mutation_p.G1543E	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1836					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AGGACTGTAGGAGAACACACT	0.483													44	210					0	0	0	0	A	31325319	A	A	31325319	3	1	128	1	0	0	0	0	1	0	0	0	1070	1174	41	2	5553	2	ASXL3	18	31325319	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	487	31325319	46751929	492	23106											
SLC39A6	25800	broad.mit.edu	37	chr18	33689584	33689584	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatacgaaacacgattttaTgttcaaatatggaaataagt	17	14	6	4	2	1	0	1	0	0	0	1	3	1	1	0	1	2	1	0	1	8	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:33689584T>A	uc010dmy.2	-	10	2530	c.2240A>T	c.(2239-2241)CAT>CTT	p.H747L		NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	747	Extracellular (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						CACGATTTTATGTTCAAATAT	0.353													21	118					0	0	0	0	A	33689584	A	A	33689584	3	1	128	1	0	0	0	0	1	0	0	0	14686	1464	51	5	31	5	SLC39A6	18	33689584	Missense_Mutation	SNP	T	TCGA-CR-6481-01A-11D-1870-08	2364265	33689584	44387664	493	23107											
CCBE1	147372	broad.mit.edu	37	chr18	57363888	57363888	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtggtgagctcgcctgaaGacttcagacacgggtattta	10	11	12	8	2	1	4	1	2	0	2	2	4	1	4	1	2	1	2	1	2	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:57363888G>C	uc002lib.2	-	2	255	c.185C>G	c.(184-186)TCT>TGT	p.S62C		NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	62					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				CTCGCCTGAAGACTTCAGACA	0.572											OREG0025022	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	117					0	0	0	0	C	57363888	C	C	57363888	3	2	128	1	0	0	0	0	1	0	0	0	2743	942	33	2	1075	2	CCBE1	18	57363888	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	23674304	57363888	20713360	494	23108											
ZNF554	115196	broad.mit.edu	37	chr19	2834250	2834250	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaaccggaggcattctttGagcgaacatcaaagaattca	14	10	8	9	2	4	2	3	1	1	1	4	4	4	3	1	2	3	1	1	2	4	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:2834250G>C	uc002lwm.2	+	5	1215	c.1017G>C	c.(1015-1017)TTG>TTC	p.L339F	ZNF554_uc002lwl.2_Missense_Mutation_p.L288F	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	339	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCATTCTTTGAGCGAACATC	0.537													9	66					0	0	0	0	C	2834250	C	C	2834250	3	2	128	1	0	0	0	0	1	0	0	0	18052	1281	45	2	1035	2	ZNF554	19	2834250	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08		2834250	56294733	495	23109											
ZNF554	115196	broad.mit.edu	37	chr19	2834551	2834551	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaagccctacgaatgcagtGaatgtggaaaggccttcagt	13	8	12	8	1	1	2	1	1	0	1	1	4	1	3	2	2	3	1	2	2	5	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:2834551G>A	uc002lwm.2	+	5	1516	c.1318G>A	c.(1318-1320)GAA>AAA	p.E440K	ZNF554_uc002lwl.2_Missense_Mutation_p.E389K	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	440	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGAATGCAGTGAATGTGGAAA	0.522													8	40					0	0	0	0	A	2834551	A	A	2834551	3	1	128	1	0	0	0	0	1	0	0	0	18052	1291	45	2	1336	2	ZNF554	19	2834551	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	301	2834551	56294432	496	23110											
UHRF1	29128	broad.mit.edu	37	chr19	4929378	4929378	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccgactccggctgctgcctgGgccagagtgagtcagacaag	8	6	14	13	2	1	3	1	1	0	2	2	4	2	3	4	2	2	2	4	2	1	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:4929378G>C	uc002mbo.2	+	3	466	c.298G>C	c.(298-300)GGC>CGC	p.G100R	UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.G113R	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	100					cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		CTGCTGCCTGGGCCAGAGTGA	0.657													6	26					0	0	0	0	C	4929378	C	C	4929378	3	2	128	1	0	0	0	0	1	0	0	0	17035	1232	43	4	343	4	UHRF1	19	4929378	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2094827	4929378	54199605	497	23111											
TRIP10	9322	broad.mit.edu	37	chr19	6741022	6741022	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccatgtcccatgtcaggAtcagttcgaggtgctcgagc	8	9	11	13	2	2	0	2	0	0	0	5	3	3	1	3	2	2	2	3	2	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:6741022A>T	uc002mfs.2	+	2	92	c.26A>T	c.(25-27)GAT>GTT	p.D9V	TRIP10_uc010dux.1_Missense_Mutation_p.D9V|TRIP10_uc002mfr.2_Missense_Mutation_p.D9V|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_5'UTR	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	9	FCH.|Required for podosome formation and interaction with AKAP9 and microtubules.|Induction of membrane tubulation.|Required for translocation to the plasma membrane in response to insulin (By similarity).				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						CCATGTCAGGATCAGTTCGAG	0.617													7	44					0	0	0	0	T	6741022	T	T	6741022	3	4	128	1	0	0	0	0	1	0	0	0	16621	347	12	5	32	5	TRIP10	19	6741022	Missense_Mutation	SNP	A	TCGA-CR-6481-01A-11D-1870-08	1811644	6741022	52387961	498	23112											
RDH8	50700	broad.mit.edu	37	chr19	10132365	10132365	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccgctgtccacgcctcctCaaccttggccttcaatgtct	5	13	6	17	2	3	0	2	0	1	0	6	0	6	0	6	1	1	1	6	1	2	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:10132365C>G	uc002mmr.2	+	6	1125	c.876C>G	c.(874-876)CTC>CTG	p.L292L		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	292					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	CACGCCTCCTCAACCTTGGCC	0.612													6	37					0	0	0	0	G	10132365	G	G	10132365	2	3	128	1	0	0	0	0	0	0	0	1	13261	813	29	2		2	RDH8	19	10132365	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	3391343	10132365	48996618	499	23113											
ANGPTL6	83854	broad.mit.edu	37	chr19	10204253	10204253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcagctgatacacgggttCaaggcccagccagtattctc	9	9	11	12	1	3	1	2	1	1	0	4	1	3	1	2	3	3	3	2	3	3	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:10204253C>T	uc002mmx.1	-	5	1112	c.994G>A	c.(994-996)GAA>AAA	p.E332K	ANGPTL6_uc002mmy.1_Missense_Mutation_p.E332K	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	332	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			TACACGGGTTCAAGGCCCAGC	0.642													7	20					0	0	0	0	T	10204253	T	T	10204253	3	4	128	1	0	0	0	0	1	0	0	0	618	835	29	2	426	2	ANGPTL6	19	10204253	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	71888	10204253	48924730	500	23114											
ANGPTL6	83854	broad.mit.edu	37	chr19	10204273	10204273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caaggcccagccagtattctCcgtctggccgcccaaagccc	8	6	9	18	2	2	0	0	0	2	0	3	0	2	0	6	2	2	1	6	2	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:10204273C>T	uc002mmx.1	-	5	1092	c.974G>A	c.(973-975)GGA>GAA	p.G325E	ANGPTL6_uc002mmy.1_Missense_Mutation_p.G325E	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	325	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			CCAGTATTCTCCGTCTGGCCG	0.647													6	20					0	0	0	0	T	10204273	T	T	10204273	3	4	128	1	0	0	0	0	1	0	0	0	618	855	30	2	446	2	ANGPTL6	19	10204273	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	20	10204273	48924710	501	23115											
PPAN-P2RY11	692312	broad.mit.edu	37	chr19	10220614	10220614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaagttgttcctgtgggcGcgagtcgcgggatgaagaag	9	9	16	7	4	1	2	1	1	0	1	3	4	2	3	1	2	0	2	1	2	3	2	rs149200523	byFrequency	TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:10220614G>A	uc002mna.2	+	7	616	c.616G>A	c.(616-618)GCG>ACG	p.A206T	PPAN-P2RY11_uc010xla.1_Missense_Mutation_p.A206T|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Missense_Mutation_p.A206T|PPAN_uc002mnb.1_Missense_Mutation_p.A153T	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	206	Brix.				RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TCCTGTGGGCGCGAGTCGCGG	0.627													8	107					0	0	0	0	A	10220614	A	A	10220614	3	1	128	1	0	0	0	0	1	0	0	0	12344	1087	38	1	642	1	PPAN-P2RY11	19	10220614	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	16341	10220614	48908369	502	23116											
ZNF627	199692	broad.mit.edu	37	chr19	11725686	11725686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgaagacccattcaaaattCccaggagaaatataaggtaa	18	9	7	7	0	1	3	1	1	0	2	2	4	2	3	2	2	0	1	2	2	7	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:11725686C>T	uc002msk.2	+	3	383	c.175C>T	c.(175-177)CCC>TCC	p.P59S	ZNF627_uc010dyf.2_5'UTR	NM_145295	NP_660338	Q7L945	ZN627_HUMAN	zinc finger protein 627	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATTCAAAATTCCCAGGAGAAA	0.279													3	21					0	0	0	0	T	11725686	T	T	11725686	3	4	128	1	0	0	0	0	1	0	0	0	18118	855	30	2	185	2	ZNF627	19	11725686	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1505072	11725686	47403297	503	23117											
ZNF563	147837	broad.mit.edu	37	chr19	12429881	12429881	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatctgaaagcttccaagatGatgaaatgttttcccgcatt	12	14	7	8	1	1	4	0	3	1	1	3	4	3	4	2	0	1	3	2	0	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:12429881G>A	uc002mtp.2	-	4	1196	c.958C>T	c.(958-960)CAT>TAT	p.H320Y		NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	320	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTCCAAGATGATGAAATGTT	0.438													23	134					0	0	0	0	A	12429881	A	A	12429881	3	1	128	1	0	0	0	0	1	0	0	0	18061	1290	45	2	476	2	ZNF563	19	12429881	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	704195	12429881	46699102	504	23118											
C19orf44	84167	broad.mit.edu	37	chr19	16611792	16611792	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctagatgagaaacacttactCctgaaagagaaccctgtgct	14	9	8	10	0	0	4	0	2	0	3	1	6	1	4	2	0	4	1	2	0	5	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:16611792C>G	uc002neh.1	+	2	262	c.189C>G	c.(187-189)CTC>CTG	p.L63L	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Silent_p.L63L|C19orf44_uc002neg.2_Silent_p.L63L|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	63											0						AACACTTACTCCTGAAAGAGA	0.478													26	192					0	0	0	0	G	16611792	G	G	16611792	2	3	128	1	0	0	0	0	0	0	0	1	1936	842	30	2		2	C19orf44	19	16611792	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	4181911	16611792	42517191	505	23119											
NWD1	284434	broad.mit.edu	37	chr19	16875993	16875993	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgccgccctgctgtggagctCcgaggcatgggtgagtccag	5	8	16	12	2	0	1	0	1	0	0	2	3	2	2	4	3	3	3	4	3	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:16875993C>A	uc002neu.3	+	10	2822	c.2400C>A	c.(2398-2400)CTC>CTA	p.L800L	NWD1_uc002net.3_Silent_p.L665L|NWD1_uc002nev.3_Silent_p.L594L			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	800							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CTGTGGAGCTCCGAGGCATGG	0.587													5	25					0.000602214	0.000619073	1	0	A	16875993	A	A	16875993	2	1	128	1	0	0	0	0	0	0	0	1	10835	842	30	2		2	NWD1	19	16875993	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	264201	16875993	42252990	506	23120											
GLT25D1	79709	broad.mit.edu	37	chr19	17691701	17691701	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agttcctgcccgtcatgttcGacaaacacccagtgtgagag	10	9	10	12	2	1	1	1	1	0	1	3	3	2	1	3	0	2	2	3	0	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:17691701G>A	uc002nhc.1	+	11	1600	c.1588G>A	c.(1588-1590)GAC>AAC	p.D530N	GLT25D1_uc010eax.1_Missense_Mutation_p.D258N|GLT25D1_uc010eay.1_Missense_Mutation_p.D59N	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	530					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0						CGTCATGTTCGACAAACACCC	0.632													6	35					0	0	0	0	A	17691701	A	A	17691701	3	1	128	1	0	0	0	0	1	0	0	0	6503	1058	37	1	1630	1	GLT25D1	19	17691701	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	815708	17691701	41437282	507	23121											
FCHO1	23149	broad.mit.edu	37	chr19	17875220	17875220	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctactcgaaggcgatggcGaaactctccaagctggccag	11	6	11	13	3	1	0	0	0	1	0	3	3	1	0	3	3	3	1	3	3	4	1	rs148025294		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:17875220G>A	uc010ebb.2	+	5	345	c.156G>A	c.(154-156)GCG>GCA	p.A52A	FCHO1_uc002nhg.3_Silent_p.A52A|FCHO1_uc002nhh.2_Silent_p.A52A|FCHO1_uc010xpw.1_Silent_p.A2A|FCHO1_uc010ebc.1_Silent_p.A59A	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	52	FCH.									breast(1)	1						AGGCGATGGCGAAACTCTCCA	0.512													9	38					0	0	0	0	A	17875220	A	A	17875220	2	1	128	1	0	0	0	0	0	0	0	1	5819	1045	37	1		1	FCHO1	19	17875220	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	183519	17875220	41253763	508	23122											
GDF15	9518	broad.mit.edu	37	chr19	18497038	18497038	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggacggtgaatggctctcaGatgctcctggtgttgctggt	6	12	15	8	1	1	2	1	1	1	1	3	3	2	3	1	5	2	4	1	5	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:18497038G>C	uc002niv.2	+	1	71	c.39G>C	c.(37-39)CAG>CAC	p.Q13H	hsa-mir-3189|MI0014233_5'Flank	NM_004864	NP_004855	Q99988	GDF15_HUMAN	growth differentiation factor 15	13					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)	1						ATGGCTCTCAGATGCTCCTGG	0.647													5	39					0	0	0	0	C	18497038	C	C	18497038	3	2	128	1	0	0	0	0	1	0	0	0	6350	933	33	2	41	2	GDF15	19	18497038	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	621818	18497038	40631945	509	23123											
ZNF682	91120	broad.mit.edu	37	chr19	20117110	20117110	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttaaaagctttgccacattCttcacatttgtagggtttct	9	17	7	8	0	3	0	1	0	2	0	3	0	3	0	1	1	2	4	1	1	3	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:20117110C>T	uc002noq.2	-	4	1324	c.1201G>A	c.(1201-1203)GAA>AAA	p.E401K	ZNF682_uc002noo.2_Missense_Mutation_p.E369K|ZNF682_uc002nop.2_Missense_Mutation_p.E369K|ZNF682_uc010eck.2_Missense_Mutation_p.E325K	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	401	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TTGCCACATTCTTCACATTTG	0.378													16	77					0	0	0	0	T	20117110	T	T	20117110	3	4	128	1	0	0	0	0	1	0	0	0	18156	922	32	2	299	2	ZNF682	19	20117110	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1620072	20117110	39011873	510	23124											
ZNF536	9745	broad.mit.edu	37	chr19	31038871	31038871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagaaaccctacaagtgtcCgcactgtgactatgccggca	11	8	10	12	2	0	2	0	2	0	1	1	3	1	2	3	1	3	2	3	1	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:31038871C>T	uc002nsu.1	+	4	2483	c.2345C>T	c.(2344-2346)CCG>CTG	p.P782L	ZNF536_uc010edd.1_Missense_Mutation_p.P782L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	782	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TACAAGTGTCCGCACTGTGAC	0.502													13	70					0	0	0	0	T	31038871	T	T	31038871	3	4	128	1	0	0	0	0	1	0	0	0	18041	652	23	1	2355	1	ZNF536	19	31038871	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	10921761	31038871	28090112	511	23125											
HPN	3249	broad.mit.edu	37	chr19	35551551	35551551	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggaaccgggtcctgtcccGatggcgagtgtttgccggtg	4	9	17	11	5	0	0	0	0	0	0	2	3	2	1	4	4	2	1	4	4	1	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:35551551G>T	uc002nxq.1	+	10	886	c.641G>T	c.(640-642)CGA>CTA	p.R214L	HPN_uc002nxr.1_Missense_Mutation_p.R214L|HPN_uc002nxs.1_Missense_Mutation_p.R56L|HPN_uc010xsh.1_Missense_Mutation_p.R183L|HPN_uc002nxt.1_Missense_Mutation_p.R98L|LOC100128675_uc010xsi.1_Intron	NM_002151	NP_002142	P05981	HEPS_HUMAN	hepsin	214	Extracellular (Potential).|Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GTCCTGTCCCGATGGCGAGTG	0.682													10	39					3.07112e-06	3.20696e-06	1	0	T	35551551	T	T	35551551	3	4	128	1	0	0	0	0	1	0	0	0	7375	1058	37	3	671	3	HPN	19	35551551	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4512680	35551551	23577432	512	23126											
CD22	933	broad.mit.edu	37	chr19	35828818	35828818	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagaagcagaatacattcacGctaaacctgcgcgaagtgac	16	6	9	10	3	1	3	1	1	0	2	1	4	1	3	1	0	4	2	1	0	7	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:35828818G>A	uc010edt.2	+	5	956	c.879G>A	c.(877-879)ACG>ACA	p.T293T	CD22_uc010xst.1_Silent_p.T121T|CD22_uc010edu.2_Silent_p.T293T|CD22_uc010edv.2_Silent_p.T293T|CD22_uc002nzb.3_Intron|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	293	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion		protein binding|sugar binding	p.T293T(1)		ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	ATACATTCACGCTAAACCTGC	0.567													4	43					0	0	0	0	A	35828818	A	A	35828818	2	1	128	1	0	0	0	0	0	0	0	1	3000	1074	38	1		1	CD22	19	35828818	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	277267	35828818	23300165	513	23127											
GAPDHS	26330	broad.mit.edu	37	chr19	36033280	36033280	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctacgtggtggagtccaCaggcgtgtacctctccatac	7	9	10	15	2	1	0	0	0	1	0	3	1	2	1	5	3	3	1	5	3	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:36033280C>G	uc002oaf.1	+	5	625	c.509C>G	c.(508-510)ACA>AGA	p.T170R	uc010eec.1_Intron|uc002oag.2_Intron	NM_014364	NP_055179	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase,	170					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)	GTGGAGTCCACAGGCGTGTAC	0.637													8	38					0	0	0	0	G	36033280	G	G	36033280	3	3	128	1	0	0	0	0	1	0	0	0	6272	478	17	4	527	4	GAPDHS	19	36033280	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	204462	36033280	23095703	514	23128											
ZNF570	148268	broad.mit.edu	37	chr19	37975067	37975067	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccactgctttgtacacaaaaGataatccccaaagaggagaa	17	7	7	10	0	0	3	0	0	0	3	1	4	1	3	3	1	2	2	3	1	6	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:37975067G>C	uc002ogk.1	+	5	1072	c.543G>C	c.(541-543)AAG>AAC	p.K181N	ZNF570_uc010efl.1_Missense_Mutation_p.K237N|ZNF570_uc010xtr.1_5'UTR	NM_144694	NP_653295	Q96NI8	ZN570_HUMAN	zinc finger protein 570	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTACACAAAAGATAATCCCCA	0.358													42	183					0	0	0	0	C	37975067	C	C	37975067	3	2	128	1	0	0	0	0	1	0	0	0	18069	933	33	2	557	2	ZNF570	19	37975067	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1941787	37975067	21153916	515	23129											
SARS2	54938	broad.mit.edu	37	chr19	39437135	39437135	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagccacacagatctcaatCtgggcgctgtccagcagctc	9	8	9	15	1	3	1	2	0	2	1	6	1	4	1	2	1	3	3	2	1	1	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:39437135C>G	uc010xuq.1	-	3	247	c.39G>C	c.(37-39)CAG>CAC	p.Q13H	FBXO17_uc002okg.1_Missense_Mutation_p.Q178H|FBXO17_uc002okf.1_Missense_Mutation_p.Q187H	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor	Error:Variant_position_missing_in_Q9NP81_after_alignment					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			AGATCTCAATCTGGGCGCTGT	0.637													12	49					0	0	0	0	G	39437135	G	G	39437135	3	3	128	1	0	0	0	0	1	0	0	0	13910	912	32	2		2	SARS2	19	39437135	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1462068	39437135	19691848	516	23130											
CCDC97	90324	broad.mit.edu	37	chr19	41828509	41828509	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctgcagcacagtagaCgacaaccccgacttcgacaa	12	6	7	16	3	0	1	0	0	0	1	3	4	2	1	4	0	3	3	4	0	3	2	rs143105404		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:41828509C>T	uc002oqg.2	+	5	1043	c.921C>T	c.(919-921)GAC>GAT	p.D307D	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	307											0						GCACAGTAGACGACAACCCCG	0.612													9	88					0	0	0	0	T	41828509	T	T	41828509	2	4	128	1	0	0	0	0	0	0	0	1	2888	535	19	1		1	CCDC97	19	41828509	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2391374	41828509	17300474	517	23131											
LIPE	3991	broad.mit.edu	37	chr19	42907160	42907160	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggctgggccagtgctgcttCagacacactgcggcgcatcg	6	7	15	13	3	1	1	1	0	0	1	2	1	1	1	1	3	3	4	1	3	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:42907160C>T	uc002otr.2	-	9	2843	c.2566G>A	c.(2566-2568)GAA>AAA	p.E856K	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	856					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				AGTGCTGCTTCAGACACACTG	0.617													6	52					0	0	0	0	T	42907160	T	T	42907160	3	4	128	1	0	0	0	0	1	0	0	0	8863	835	29	2	672	2	LIPE	19	42907160	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1078651	42907160	16221823	518	23132											
PSG3	5671	broad.mit.edu	37	chr19	43243011	43243011	+	Frame_Shift_Del	DEL	C	-	-																															tgcattggaatatactgtttCtcgtccactgtatgcaggcc																										TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:43243011delC	uc002oue.2	-	2	427	c.295delG	c.(295-297)GAAfs	p.E99fs	PSG3_uc002ouf.2_RNA|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Frame_Shift_Del_p.E121fs	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	99	Ig-like V-type.				defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TATACTGTTTCTCGTCCACTG	0.453													---	---	---								-	43243011	-	-	43243011	7	5	128	1	0	1	0	1	0	0	0	0	12718	922	32	0	1011	0	PSG3	19	43243011	Frame_Shift_Del	DEL	C	TCGA-CR-6481-01A-11D-1870-08	335851	43243011	15885972	519	23133											
FBXO46	23403	broad.mit.edu	37	chr19	46215859	46215859	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgatcttgtccttggctcGggccccaggacctgggctgc	3	11	14	13	1	1	1	0	1	1	0	3	2	2	2	4	4	1	2	4	4	0	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:46215859G>A	uc002pcy.2	-	2	1020	c.895C>T	c.(895-897)CGA>TGA	p.R299*	FBXO46_uc002pcz.2_Nonsense_Mutation_p.R299*	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	299							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		TCCTTGGCTCGGGCCCCAGGA	0.682													4	16					0	0	0	0	A	46215859	A	A	46215859	4	1	128	1	0	0	0	0	0	1	0	0	5787	1124	39	1	920	1	FBXO46	19	46215859	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2972848	46215859	12913124	520	23134											
PNMAL1	55228	broad.mit.edu	37	chr19	46973455	46973455	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgagatcgccatgctttCagcatcacccacctcaggat	9	10	7	15	1	4	1	3	1	1	1	5	3	4	2	3	1	2	2	3	1	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:46973455C>T	uc002peq.3	-	2	1144	c.838G>A	c.(838-840)GAA>AAA	p.E280K	PNMAL1_uc002per.3_Missense_Mutation_p.E280K	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	280											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GCCATGCTTTCAGCATCACCC	0.517													27	151					0	0	0	0	T	46973455	T	T	46973455	3	4	128	1	0	0	0	0	1	0	0	0	12212	835	29	2	511	2	PNMAL1	19	46973455	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	757596	46973455	12155528	521	23135											
LMTK3	114783	broad.mit.edu	37	chr19	49004553	49004553	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcctcaccagatgttgctctCgcggctctggtccaccacca	6	10	8	17	2	3	1	1	0	2	1	6	1	5	1	5	2	1	3	5	2	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:49004553C>T	uc002pjk.2	-	10	1075	c.1075G>A	c.(1075-1077)GAG>AAG	p.E359K		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		ATGTTGCTCTCGCGGCTCTGG	0.662													13	66					0	0	0	0	T	49004553	T	T	49004553	3	4	128	1	0	0	0	0	1	0	0	0	8902	893	31	1	3422	1	LMTK3	19	49004553	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2031098	49004553	10124430	522	23136											
PPFIA3	8541	broad.mit.edu	37	chr19	49652886	49652886	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgaggcgtaactcccgactCagctgagatgttgcccccca	8	7	10	16	3	1	1	1	1	0	1	2	4	2	1	5	1	3	3	5	1	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:49652886C>G	uc002pmr.2	+	28	3769	c.3437C>G	c.(3436-3438)TCA>TGA	p.S1146*	PPFIA3_uc010yai.1_RNA|PPFIA3_uc002pms.2_Nonsense_Mutation_p.S1005*|PPFIA3_uc002pmt.2_Nonsense_Mutation_p.S285*|PPFIA3_uc002pmu.1_Nonsense_Mutation_p.S195*	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	1146						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		ACTCCCGACTCAGCTGAGATG	0.647													3	40					0	0	0	0	G	49652886	G	G	49652886	4	3	128	1	0	0	0	0	0	1	0	0	12366	838	29	2	3543	2	PPFIA3	19	49652886	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	648333	49652886	9476097	523	23137											
MYH14	79784	broad.mit.edu	37	chr19	50780093	50780093	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccacgaggcggcagtgcagGagctgaggcagcgccacggc	8	3	17	13	4	0	1	0	1	0	0	1	3	1	2	2	5	3	4	2	5	0	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:50780093G>A	uc002prr.1	+	27	3684	c.3637G>A	c.(3637-3639)GAG>AAG	p.E1213K	MYH14_uc010enu.1_Missense_Mutation_p.E1254K|MYH14_uc002prq.1_Missense_Mutation_p.E1221K	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1213	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GGCAGTGCAGGAGCTGAGGCA	0.532													14	51					0	0	0	0	A	50780093	A	A	50780093	3	1	128	1	0	0	0	0	1	0	0	0	10086	1175	41	2	3870	2	MYH14	19	50780093	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1127207	50780093	8348890	524	23138											
ZNF808	388558	broad.mit.edu	37	chr19	53058569	53058569	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acggtttgtgacaaggctttCgtgcgtaattcatacctggc	8	13	11	9	3	1	1	1	1	0	0	2	1	1	1	1	3	2	3	1	3	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:53058569C>T	uc010epq.1	+	5	2577	c.2400C>T	c.(2398-2400)TTC>TTT	p.F800F	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	800	C2H2-type 21.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		ACAAGGCTTTCGTGCGTAATT	0.408													24	190					0	0	0	0	T	53058569	T	T	53058569	2	4	128	1	0	0	0	0	0	0	0	1	18240	883	31	1		1	ZNF808	19	53058569	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2278476	53058569	6070414	525	23139											
ZNF816A	125893	broad.mit.edu	37	chr19	53454322	53454322	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagctataattaaaggcttTgccacactcattactttggc	11	14	7	9	0	1	1	1	1	0	0	1	1	1	1	1	2	3	2	1	2	5	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:53454322T>C	uc002qal.1	-	5	1007	c.706A>G	c.(706-708)AAA>GAA	p.K236E	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.K220E	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	236	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		TTAAAGGCTTTGCCACACTCA	0.348													14	74					0	0	0	0	C	53454322	C	C	53454322	3	2	128	1	0	0	0	0	1	0	0	0	18244	1821	63	5	1253	5	ZNF816A	19	53454322	Missense_Mutation	SNP	T	TCGA-CR-6481-01A-11D-1870-08	395753	53454322	5674661	526	23140											
SUV420H2	84787	broad.mit.edu	37	chr19	55857665	55857665	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtgacatgcttctacggcGagggcttcttcggcgagaag	8	9	15	9	4	2	2	0	1	2	1	3	4	2	2	0	4	2	2	0	4	2	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:55857665G>A	uc002qkj.3	+	7	903	c.655G>A	c.(655-657)GAG>AAG	p.E219K	SUV420H2_uc002qkl.2_Missense_Mutation_p.E104K	NM_032701	NP_116090	Q86Y97	SV422_HUMAN	suppressor of variegation 4-20 homolog 2	219	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding				0	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CTTCTACGGCGAGGGCTTCTT	0.622													8	65					0	0	0	0	A	55857665	A	A	55857665	3	1	128	1	0	0	0	0	1	0	0	0	15481	1059	37	1	677	1	SUV420H2	19	55857665	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	2403343	55857665	3271318	527	23141											
USP29	57663	broad.mit.edu	37	chr19	57641988	57641988	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaggagcttccagtggctGactcactgatggaccaggga	12	7	13	9	0	1	2	1	2	0	0	2	5	2	5	2	4	1	2	2	4	2	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:57641988G>A	uc002qny.2	+	4	2301	c.1945G>A	c.(1945-1947)GAC>AAC	p.D649N		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	649					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCCAGTGGCTGACTCACTGAT	0.498													6	51					0	0	0	0	A	57641988	A	A	57641988	3	1	128	1	0	0	0	0	1	0	0	0	17127	1290	45	2	1947	2	USP29	19	57641988	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1784323	57641988	1486995	528	23142											
LBP	3929	broad.mit.edu	37	chr20	36992685	36992685	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atagcttagtggaagcccctCgggcaacagcccagatgctg	10	7	12	12	1	0	1	0	0	0	1	1	2	0	2	3	2	5	3	3	2	4	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:36992685C>T	uc002xic.1	+	7	744	c.709C>T	c.(709-711)CGG>TGG	p.R237W		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	237					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				GGAAGCCCCTCGGGCAACAGC	0.547													9	37					0	0	0	0	T	36992685	T	T	36992685	3	4	128	1	0	0	0	0	1	0	0	0	8691	875	31	1	735	1	LBP	20	36992685	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08		36992685	26032835	529	23143											
SFRS6	6431	broad.mit.edu	37	chr20	42089355	42089355	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttgtccagttccaggtcgcgGagcaaaggtcgatcacgttc	8	10	12	11	4	1	0	1	0	0	0	6	2	3	1	2	3	1	3	2	3	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:42089355G>C	uc010zwg.1	+	6	857	c.687G>C	c.(685-687)CGG>CGC	p.R229R	SFRS6_uc002xki.2_Silent_p.R100R|SFRS6_uc002xkk.2_Intron	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	229	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCAGGTCGCGGAGCAAAGGTC	0.438													7	36					0	0	0	0	C	42089355	C	C	42089355	2	2	128	1	0	0	0	0	0	0	0	1	14246	1161	41	2		2	SFRS6	20	42089355	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	5096670	42089355	20936165	530	23144											
ARFGEF2	10564	broad.mit.edu	37	chr20	47649614	47649614	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgtgaaattatgcagtttGacctgatccctgagctccga	9	13	10	9	1	0	4	0	4	0	0	2	5	2	4	3	0	2	3	3	0	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:47649614G>C	uc002xtx.3	+	39	5388	c.5236G>C	c.(5236-5238)GAC>CAC	p.D1746H	ARFGEF2_uc010zyf.1_Missense_Mutation_p.D1039H	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1746					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TATGCAGTTTGACCTGATCCC	0.418													9	57					0	0	0	0	C	47649614	C	C	47649614	3	2	128	1	0	0	0	0	1	0	0	0	853	1290	45	2	5390	2	ARFGEF2	20	47649614	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	5560259	47649614	15375906	531	23145											
ZNF217	7764	broad.mit.edu	37	chr20	52199332	52199332	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgtacattaagagggattGagttggcatgtttcctgtca	10	14	11	6	0	1	2	1	1	0	1	2	3	2	3	1	2	1	4	1	2	2	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:52199332G>A	uc002xwq.3	-	1	305	c.34C>T	c.(34-36)CAA>TAA	p.Q12*	ZNF217_uc010gij.1_Nonsense_Mutation_p.Q4*	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	12					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			AAGAGGGATTGAGTTGGCATG	0.468													15	97					0	0	0	0	A	52199332	A	A	52199332	4	1	128	1	0	0	0	0	0	1	0	0	17839	1299	45	2	3128	2	ZNF217	20	52199332	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	4549718	52199332	10826188	532	23146											
DOK5	55816	broad.mit.edu	37	chr20	53208154	53208154	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccttttgtttttctcccaGagagattcaatgtgtatttg	9	18	7	7	0	2	2	1	0	1	2	3	3	2	2	2	0	1	2	2	0	3	7			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:53208154G>C	uc002xwy.2	+	5	630	c.410_splice	c.e5-1	p.E137_splice	DOK5_uc010gin.2_Splice_Site_p.E29_splice|DOK5_uc002xwz.2_Intron	NM_018431	NP_060901	Q9P104	DOK5_HUMAN	docking protein 5								insulin receptor binding			ovary(1)	1			Colorectal(105;0.202)			TTTTCTCCCAGAGAGATTCAA	0.368													5	72					0	0	0	0	C	53208154	C	C	53208154	5	2	128	1	0	0	0	0	0	0	1	0	4722	956	33	2	427	2	DOK5	20	53208154	Splice_Site	SNP	G	TCGA-CR-6481-01A-11D-1870-08	1008822	53208154	9817366	533	23147											
DIDO1	11083	broad.mit.edu	37	chr20	61525058	61525058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactgacaggtatcttgggtCaggagatgaggatggcttag	11	10	15	5	0	2	3	1	2	1	1	2	5	2	4	0	5	1	2	0	5	3	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:61525058C>T	uc002ydr.1	-	12	3325	c.3061G>A	c.(3061-3063)GAC>AAC	p.D1021N	DIDO1_uc002yds.1_Missense_Mutation_p.D1021N|DIDO1_uc002ydt.1_Missense_Mutation_p.D1021N|DIDO1_uc002ydu.1_Missense_Mutation_p.D1021N	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1021					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TATCTTGGGTCAGGAGATGAG	0.483													18	87					0	0	0	0	T	61525058	T	T	61525058	3	4	128	1	0	0	0	0	1	0	0	0	4544	826	29	2	3710	2	DIDO1	20	61525058	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	8316904	61525058	1500462	534	23148											
DIDO1	11083	broad.mit.edu	37	chr20	61525160	61525160	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccaccatgtgggtgctgtCtgggcgggatgctgcggagg	4	10	18	9	2	1	0	0	0	1	0	2	2	2	2	2	5	3	2	2	5	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:61525160C>T	uc002ydr.1	-	12	3223	c.2959G>A	c.(2959-2961)GAC>AAC	p.D987N	DIDO1_uc002yds.1_Missense_Mutation_p.D987N|DIDO1_uc002ydt.1_Missense_Mutation_p.D987N|DIDO1_uc002ydu.1_Missense_Mutation_p.D987N	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	987					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TGGGTGCTGTCTGGGCGGGAT	0.622													16	86					0	0	0	0	T	61525160	T	T	61525160	3	4	128	1	0	0	0	0	1	0	0	0	4544	913	32	2	3812	2	DIDO1	20	61525160	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	102	61525160	1500360	535	23149											
CRYZL1	9946	broad.mit.edu	37	chr21	34994360	34994360	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aataaatcctttttcatcttCatttctgccagaagctaaat	13	16	3	9	0	4	1	2	0	2	1	5	1	5	1	2	0	2	1	2	0	6	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr21:34994360C>T	uc011adw.1	-	4	339	c.159G>A	c.(157-159)ATG>ATA	p.M53I	DONSON_uc002ysn.1_Intron|CRYZL1_uc002ysr.1_Missense_Mutation_p.M77I|CRYZL1_uc002yss.1_RNA|CRYZL1_uc002yst.1_RNA|CRYZL1_uc002ysu.2_Missense_Mutation_p.M53I	NM_145858	NP_665857	O95825	QORL1_HUMAN	crystallin, zeta-like 1	53					quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding				0						TTTTCATCTTCATTTCTGCCA	0.338													28	119					0	0	0	0	T	34994360	T	T	34994360	3	4	128	1	0	0	0	0	1	0	0	0	3938	826	29	2	930	2	CRYZL1	21	34994360	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08		34994360	13135535	536	23150											
ITSN1	6453	broad.mit.edu	37	chr21	35166702	35166702	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaaaagtccatggaggctGaacgactgaaacagaaagaa	19	4	11	7	1	0	4	0	2	0	2	1	6	1	5	1	2	3	2	1	2	6	0			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr21:35166702G>A	uc002yta.1	+	17	2150	c.1882G>A	c.(1882-1884)GAA>AAA	p.E628K	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E628K|ITSN1_uc010gmg.2_Missense_Mutation_p.E591K|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E628K|ITSN1_uc010gmi.2_Missense_Mutation_p.E591K|ITSN1_uc010gmj.2_Missense_Mutation_p.E512K|ITSN1_uc002ysy.2_Missense_Mutation_p.E628K|ITSN1_uc002ysx.2_Missense_Mutation_p.E591K|ITSN1_uc002ytb.1_Missense_Mutation_p.E628K|ITSN1_uc002ytc.1_Missense_Mutation_p.E628K|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E591K|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E628K|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E562K	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	628	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						CATGGAGGCTGAACGACTGAA	0.383													12	67					0	0	0	0	A	35166702	A	A	35166702	3	1	128	1	0	0	0	0	1	0	0	0	7965	1291	45	2	1944	2	ITSN1	21	35166702	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	172342	35166702	12963193	537	23151											
RRP1	8568	broad.mit.edu	37	chr21	45219458	45219458	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttttgttccaggctccatCtgcagggctgaacctgaggc	6	11	11	13	0	1	2	0	2	1	0	3	2	3	2	4	3	2	4	4	3	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr21:45219458C>T	uc002zds.2	+	9	912	c.819C>T	c.(817-819)ATC>ATT	p.I273I	RRP1_uc011aez.1_Silent_p.I273I|RRP1_uc010gpk.1_Silent_p.I123I|RRP1_uc010gpl.1_Silent_p.I171I|RRP1_uc010gpm.1_Silent_p.I140I	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	273					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		CAGGCTCCATCTGCAGGGCTG	0.647													5	45					0	0	0	0	T	45219458	T	T	45219458	2	4	128	1	0	0	0	0	0	0	0	1	13750	903	32	2		2	RRP1	21	45219458	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	10052756	45219458	2910437	538	23152											
CECR5	27440	broad.mit.edu	37	chr22	17630458	17630458	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccccagcagggctgacagctCctgggctttgctgtgttgta	5	11	13	12	0	0	1	0	1	0	0	1	1	1	1	3	2	3	7	3	2	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:17630458C>T	uc002zmf.2	-	2	332	c.304G>A	c.(304-306)GAG>AAG	p.E102K	CECR5_uc002zme.2_5'Flank|CECR5_uc002zmg.2_Intron|CECR5_uc002zmh.2_Missense_Mutation_p.E72K	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	102							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				GCTGACAGCTCCTGGGCTTTG	0.597													14	95					0	0	0	0	T	17630458	T	T	17630458	3	4	128	1	0	0	0	0	1	0	0	0	3222	864	30	2	995	2	CECR5	22	17630458	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08		17630458	33674108	539	23153											
TXNRD2	10587	broad.mit.edu	37	chr22	19868160	19868160	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacattgtcgtagtccatCagatctgaggacccgccgaa	10	9	9	13	3	3	2	2	1	1	1	5	4	4	3	3	1	0	1	3	1	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:19868160C>A	uc011ahc.1	-	13	1200	c.1167G>T	c.(1165-1167)CTG>CTT	p.L389L	TXNRD2_uc002zql.1_Silent_p.L143L|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Silent_p.L388L|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_Silent_p.L39L	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	389					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					CGTAGTCCATCAGATCTGAGG	0.612													4	48					0.00909568	0.00922123	1	0	A	19868160	A	A	19868160	2	1	128	1	0	0	0	0	0	0	0	1	16876	813	29	2		2	TXNRD2	22	19868160	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	2237702	19868160	31436406	540	23154											
GGA1	26088	broad.mit.edu	37	chr22	38028118	38028118	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtggtggtttccatgctGagcaccgccccccagcccat	5	9	12	15	1	0	1	0	1	0	0	1	1	1	1	6	3	3	3	6	3	0	1			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:38028118G>A	uc003atc.2	+	15	2009	c.1644G>A	c.(1642-1644)CTG>CTA	p.L548L	GGA1_uc003atd.2_Silent_p.L461L|GGA1_uc003ate.2_Silent_p.L544L|GGA1_uc003atf.2_Silent_p.L475L|SH3BP1_uc003atg.1_5'Flank	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	548	GAE.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					TTTCCATGCTGAGCACCGCCC	0.627													3	21					0	0	0	0	A	38028118	A	A	38028118	2	1	128	1	0	0	0	0	0	0	0	1	6389	1277	45	2		2	GGA1	22	38028118	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	18159958	38028118	13276448	541	23155											
ST13	6767	broad.mit.edu	37	chr22	41240869	41240869	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttcatctcccatttcttGaggagcatcagtgtctggtt	7	17	8	9	0	5	1	2	1	3	0	6	2	5	2	1	2	1	2	1	2	0	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:41240869G>A	uc003aze.2	-	4	432	c.289C>T	c.(289-291)CAA>TAA	p.Q97*	ST13_uc011aow.1_Nonsense_Mutation_p.Q87*	NM_003932	NP_003923	P50502	F10A1_HUMAN	heat shock 70kD protein binding protein	97							protein binding, bridging				0						CCCATTTCTTGAGGAGCATCA	0.408													5	18					0	0	0	0	A	41240869	A	A	41240869	4	1	128	1	0	0	0	0	0	1	0	0	15276	1299	45	2	856	2	ST13	22	41240869	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3212751	41240869	10063697	542	23156											
WBP2NL	164684	broad.mit.edu	37	chr22	42423140	42423140	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagcccaggctcctgaaaaCgaggcttctcttccctctgc	7	9	9	16	1	2	1	0	1	2	0	5	2	4	1	3	2	3	3	3	2	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:42423140C>T	uc011ape.1	+	7	901	c.885C>T	c.(883-885)AAC>AAT	p.N295N	WBP2NL_uc003bbt.2_Silent_p.N295N|WBP2NL_uc011apk.1_Silent_p.N167N|WBP2NL_uc003bbu.2_RNA|WBP2NL_uc003bbv.1_RNA	NM_152613	NP_689826	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	295					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			ovary(2)	2						CTCCTGAAAACGAGGCTTCTC	0.527													19	83					0	0	0	0	T	42423140	T	T	42423140	2	4	128	1	0	0	0	0	0	0	0	1	17328	535	19	1		1	WBP2NL	22	42423140	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	1182271	42423140	8881426	543	23157											
NUP50	10762	broad.mit.edu	37	chr22	45571788	45571788	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acttcagtctgacactggagGagcctttaaaggttttaaag	12	12	10	7	0	2	1	1	1	1	0	2	3	2	3	1	3	1	1	1	3	4	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:45571788G>T	uc003bfr.2	+	4	629	c.167G>T	c.(166-168)GGA>GTA	p.G56V	NUP50_uc003bfs.2_Missense_Mutation_p.G28V|NUP50_uc011aqn.1_Intron|NUP50_uc003bft.2_Missense_Mutation_p.G28V|NUP50_uc011aqo.1_5'Flank	NM_007172	NP_009103	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa isoform b	56	Gly-rich.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		GACACTGGAGGAGCCTTTAAA	0.463													15	95					0.000422831	0.000436024	1	0	T	45571788	T	T	45571788	3	4	128	1	0	0	0	0	1	0	0	0	10820	1174	41	2	177	2	NUP50	22	45571788	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3148648	45571788	5732778	544	23158											
FAM118A	55007	broad.mit.edu	37	chr22	45728405	45728405	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccctctttctttactccGtgccgaataaggtggatttg	7	14	10	10	2	2	0	0	0	2	0	3	2	3	1	3	3	2	0	3	3	3	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:45728405G>A	uc003bfz.3	+	7	1367	c.751G>A	c.(751-753)GTG>ATG	p.V251M	FAM118A_uc003bga.3_Missense_Mutation_p.V251M|FAM118A_uc011aqr.1_Missense_Mutation_p.V69M	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	251						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TCTTTACTCCGTGCCGAATAA	0.478													22	138					0	0	0	0	A	45728405	A	A	45728405	3	1	128	1	0	0	0	0	1	0	0	0	5439	1145	40	1	769	1	FAM118A	22	45728405	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	156617	45728405	5576161	545	23159											
ARSE	415	broad.mit.edu	37	chrX	2878422	2878422	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atataattgtatcttaccaaGaatggtgcagatgtaacatg	15	13	8	5	0	1	2	0	0	1	2	1	2	1	2	1	1	3	3	1	1	7	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:2878422G>A	uc004crc.3	-	2	270	c.20C>T	c.(19-21)TCT>TTT	p.S7F	ARSE_uc011mhi.1_Missense_Mutation_p.S7F|ARSE_uc011mhh.1_5'UTR	NM_000047	NP_000038	P51690	ARSE_HUMAN	arylsulfatase E precursor	7					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			ovary(1)|central_nervous_system(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATCTTACCAAGAATGGTGCAG	0.244													11	21					0	0	0	0	A	2878422	A	A	2878422	3	1	128	1	0	0	0	0	1	0	0	0	992	942	33	2	1789	2	ARSE	23	2878422	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08		2878422	152392138	546	23160											
PHKA2	5256	broad.mit.edu	37	chrX	18956826	18956826	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacattcaatgttttcgaaGagcttgagttcagcagggtc	10	13	10	8	1	3	2	3	1	0	1	5	3	3	2	0	1	2	4	0	1	2	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:18956826G>T	uc004cyv.3	-	10	1390	c.960C>A	c.(958-960)CTC>CTA	p.L320L		NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	320					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					TGTTTTCGAAGAGCTTGAGTT	0.383													15	35					1.02788e-11	1.0994e-11	1	0	T	18956826	T	T	18956826	2	4	128	1	0	0	0	0	0	0	0	1	11899	929	33	2		2	PHKA2	23	18956826	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	16078404	18956826	136313734	547	23161											
DDX3X	1654	broad.mit.edu	37	chrX	41206168	41206168	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atattactaaggatttgttgGatcttcttgttgaagctaaa	12	17	8	4	0	2	1	0	1	2	0	2	3	2	3	0	2	2	3	0	2	6	9			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:41206168G>C	uc004dfe.2	+	15	2527	c.1672G>C	c.(1672-1674)GAT>CAT	p.D558H	DDX3X_uc004dff.2_Missense_Mutation_p.D558H|DDX3X_uc011mkq.1_Missense_Mutation_p.D542H|DDX3X_uc011mkr.1_Missense_Mutation_p.D428H|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	558	Helicase C-terminal.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						GGATTTGTTGGATCTTCTTGT	0.393										HNSCC(61;0.18)			15	24					0	0	0	0	C	41206168	C	C	41206168	3	2	128	1	0	0	0	0	1	0	0	0	4375	1174	41	2	1730	2	DDX3X	23	41206168	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	22249342	41206168	114064392	548	23162											
DDX3X	1654	broad.mit.edu	37	chrX	41206210	41206210	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaagtgccgtcttggttaGaaaacatggcttatgaacac	14	10	10	7	1	1	3	0	1	1	2	1	3	1	3	1	2	3	2	1	2	7	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:41206210G>C	uc004dfe.2	+	15	2569	c.1714G>C	c.(1714-1716)GAA>CAA	p.E572Q	DDX3X_uc004dff.2_Missense_Mutation_p.E572Q|DDX3X_uc011mkq.1_Missense_Mutation_p.E556Q|DDX3X_uc011mkr.1_Missense_Mutation_p.E442Q|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	572	Helicase C-terminal.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						GTCTTGGTTAGAAAACATGGC	0.403										HNSCC(61;0.18)			16	22					0	0	0	0	C	41206210	C	C	41206210	3	2	128	1	0	0	0	0	1	0	0	0	4375	943	33	2	1772	2	DDX3X	23	41206210	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	42	41206210	114064350	549	23163											
NONO	4841	broad.mit.edu	37	chrX	70514197	70514197	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttacagttcgaaaccttcctCagtatgtgtccaacgaactg	11	12	7	11	2	1	0	1	0	0	0	4	2	3	0	3	0	4	2	3	0	5	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:70514197C>T	uc004dzo.2	+	6	1179	c.469C>T	c.(469-471)CAG>TAG	p.Q157*	BCYRN1_uc011mpt.1_Intron|NONO_uc004dzn.2_Nonsense_Mutation_p.Q157*|NONO_uc004dzp.2_Nonsense_Mutation_p.Q157*|NONO_uc011mpv.1_Nonsense_Mutation_p.Q68*|NONO_uc004dzq.2_Nonsense_Mutation_p.Q26*	NM_001145408	NP_001138880	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	157	RRM 2.|DBHS.				DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	ovary(2)|kidney(2)	4	Renal(35;0.156)					AAACCTTCCTCAGTATGTGTC	0.517			T	TFE3	papillary renal cancer								16	41					0	0	0	0	T	70514197	T	T	70514197	4	4	128	1	0	0	0	0	0	1	0	0	10588	827	29	2	479	2	NONO	23	70514197	Nonsense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	29307987	70514197	84756363	550	23164											
BRWD3	254065	broad.mit.edu	37	chrX	79980560	79980560	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagaacgaatacttcatcatCatgtccctataataaaaatc	17	12	3	9	1	3	1	3	0	0	1	5	2	4	1	1	0	2	0	1	0	9	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:79980560C>T	uc004edt.2	-	15	1656	c.1393G>A	c.(1393-1395)GAT>AAT	p.D465N	BRWD3_uc004edo.2_Missense_Mutation_p.D61N|BRWD3_uc004edp.2_Missense_Mutation_p.D294N|BRWD3_uc004edq.2_Missense_Mutation_p.D61N|BRWD3_uc010nmj.1_Missense_Mutation_p.D61N|BRWD3_uc004edr.2_Missense_Mutation_p.D135N|BRWD3_uc004eds.2_Missense_Mutation_p.D61N|BRWD3_uc004edu.2_Missense_Mutation_p.D135N|BRWD3_uc004edv.2_Missense_Mutation_p.D61N|BRWD3_uc004edw.2_Missense_Mutation_p.D61N|BRWD3_uc004edx.2_Missense_Mutation_p.D61N|BRWD3_uc004edy.2_Missense_Mutation_p.D61N|BRWD3_uc004edz.2_Missense_Mutation_p.D135N|BRWD3_uc004eea.2_Missense_Mutation_p.D135N|BRWD3_uc004eeb.2_Missense_Mutation_p.D61N	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	465	WD 8.									ovary(4)	4						ACTTCATCATCATGTCCCTAT	0.373													11	21					0	0	0	0	T	79980560	T	T	79980560	3	4	128	1	0	0	0	0	1	0	0	0	1531	826	29	2	4123	2	BRWD3	23	79980560	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	9466363	79980560	75290000	551	23165											
BRWD3	254065	broad.mit.edu	37	chrX	79989634	79989634	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccgtatgtgactctaattCagcaattttctcaggaacct	11	14	6	10	1	3	1	2	1	2	0	4	2	3	2	2	1	3	2	2	1	5	6			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:79989634C>T	uc004edt.2	-	11	1332	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_Missense_Mutation_p.E186K|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_5'UTR|BRWD3_uc004edr.2_Missense_Mutation_p.E27K|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_Missense_Mutation_p.E27K|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_Missense_Mutation_p.E27K|BRWD3_uc004eea.2_Missense_Mutation_p.E27K|BRWD3_uc004eeb.2_5'UTR	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	357										ovary(4)	4						GACTCTAATTCAGCAATTTTC	0.338													20	46					0	0	0	0	T	79989634	T	T	79989634	3	4	128	1	0	0	0	0	1	0	0	0	1531	835	29	2	4463	2	BRWD3	23	79989634	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	9074	79989634	75280926	552	23166											
KLHL4	56062	broad.mit.edu	37	chrX	86890739	86890739	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggcatgatgcccctgcttCcaaccattgctccaggcttt	6	11	10	14	0	0	1	0	1	0	0	2	1	2	1	5	3	4	4	5	3	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:86890739C>T	uc004efb.2	+	9	2071	c.1889C>T	c.(1888-1890)TCC>TTC	p.S630F	KLHL4_uc004efa.2_Missense_Mutation_p.S630F	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	630	Kelch 5.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCCCCTGCTTCCAACCATTGC	0.403													12	27					0	0	0	0	T	86890739	T	T	86890739	3	4	128	1	0	0	0	0	1	0	0	0	8430	855	30	2	1923	2	KLHL4	23	86890739	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	6901105	86890739	68379821	553	23167											
BTK	695	broad.mit.edu	37	chrX	100604914	100604914	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctagaatattgctcagaaGaattttgaaagtgggacgct	14	12	10	5	1	2	4	1	1	1	3	2	5	2	5	0	1	1	2	0	1	6	5			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:100604914G>A	uc004ehg.2	-	19	2132	c.1939C>T	c.(1939-1941)CTT>TTT	p.L647F	TIMM8A_uc004ehd.2_5'Flank|TIMM8A_uc011mri.1_5'Flank|BTK_uc004ehf.2_Missense_Mutation_p.L147F|BTK_uc010nnh.2_RNA|BTK_uc010nni.2_RNA|BTK_uc004ehe.2_RNA|BTK_uc010nnj.2_RNA|BTK_uc010nnk.2_RNA|BTK_uc010nnl.2_Missense_Mutation_p.L123F|BTK_uc010nnm.2_Missense_Mutation_p.L206F|BTK_uc010nnn.2_Missense_Mutation_p.L471F|BTK_uc010nno.2_Missense_Mutation_p.L681F	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	647	Protein kinase.		L -> P (in XLA).		calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TTGCTCAGAAGAATTTTGAAA	0.393									Agammaglobulinemia_X-linked				32	80					0	0	0	0	A	100604914	A	A	100604914	3	1	128	1	0	0	0	0	1	0	0	0	1562	942	33	2	44	2	BTK	23	100604914	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	13714175	100604914	54665646	554	23168											
RNF113A	7737	broad.mit.edu	37	chrX	119005174	119005174	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggatcttctggctgcgctCaaagatggcttgtgcatcgc	6	12	12	11	2	3	1	1	0	2	1	4	2	3	2	0	3	2	4	0	3	1	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:119005174C>T	uc004esb.2	-	1	618	c.403G>A	c.(403-405)GAG>AAG	p.E135K	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	135							nucleic acid binding|zinc ion binding			breast(2)	2						TGGCTGCGCTCAAAGATGGCT	0.527													18	253					0	0	0	0	T	119005174	T	T	119005174	3	4	128	1	0	0	0	0	1	0	0	0	13492	835	29	2	632	2	RNF113A	23	119005174	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	18400260	119005174	36265386	555	23169			2	31		4	4	235	C		1.224203e-08
RNF113A	7737	broad.mit.edu	37	chrX	119005250	119005250	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcccatatcctctggtccCacgggtttcgccgaacgggt	5	10	11	15	4	1	0	0	0	1	0	5	1	4	0	4	3	1	2	4	3	2	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:119005250C>T	uc004esb.2	-	1	542	c.327G>A	c.(325-327)GTG>GTA	p.V109V	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	109							nucleic acid binding|zinc ion binding			breast(2)	2						CCTCTGGTCCCACGGGTTTCG	0.562													14	181					0	0	0	0	T	119005250	T	T	119005250	2	4	128	1	0	0	0	0	0	0	0	1	13492	581	21	4		4	RNF113A	23	119005250	Silent	SNP	C	TCGA-CR-6481-01A-11D-1870-08	76	119005250	36265310	556	23170			2	31		4	4	235	C		1.224203e-08
RNF113A	7737	broad.mit.edu	37	chrX	119005303	119005303	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacgccgagactctcgggctCattttcctcttcctcttcgc	4	13	7	17	4	4	1	1	0	3	1	8	2	6	1	3	1	0	1	3	1	0	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:119005303C>T	uc004esb.2	-	1	489	c.274G>A	c.(274-276)GAG>AAG	p.E92K	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	92	Poly-Glu.						nucleic acid binding|zinc ion binding			breast(2)	2						CTCTCGGGCTCATTTTCCTCT	0.547													11	145					0	0	0	0	T	119005303	T	T	119005303	3	4	128	1	0	0	0	0	1	0	0	0	13492	835	29	2	761	2	RNF113A	23	119005303	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	53	119005303	36265257	557	23171			2	31		4	4	235	C		1.224203e-08
RNF113A	7737	broad.mit.edu	37	chrX	119005408	119005408	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgggtcacccgcttcttttCcggtcgaaccacagtgcagc	6	10	11	14	3	2	0	1	0	1	0	4	1	3	0	3	2	3	2	3	2	1	3			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:119005408C>T	uc004esb.2	-	1	384	c.169G>A	c.(169-171)GAA>AAA	p.E57K	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	57							nucleic acid binding|zinc ion binding			breast(2)	2						CGCTTCTTTTCCGGTCGAACC	0.602													6	133					0	0	0	0	T	119005408	T	T	119005408	3	4	128	1	0	0	0	0	1	0	0	0	13492	864	30	2	866	2	RNF113A	23	119005408	Missense_Mutation	SNP	C	TCGA-CR-6481-01A-11D-1870-08	105	119005408	36265152	558	23172			2	31		4	4	235	C		1.224203e-08
GRIA3	2892	broad.mit.edu	37	chrX	122537305	122537305	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggtttgtgcctttctcaGatcagcaaatcagcaatgac	13	11	8	9	0	3	2	3	1	1	1	4	2	3	2	1	1	3	3	1	1	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:122537305G>A	uc004etq.3	+	10	1521	c.1228G>A	c.(1228-1230)GAT>AAT	p.D410N	GRIA3_uc004etr.3_Missense_Mutation_p.D410N|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.D394N	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	410	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	GCCTTTCTCAGATCAGCAAAT	0.443													58	97					0	0	0	0	A	122537305	A	A	122537305	3	1	128	1	0	0	0	0	1	0	0	0	6808	942	33	2	1262	2	GRIA3	23	122537305	Missense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	3531897	122537305	32733255	559	23173											
IGSF1	3547	broad.mit.edu	37	chrX	130410218	130410218	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagagtgggtttggggtaGaattctgaaattaaagagac	14	10	15	2	0	1	4	0	1	1	3	1	6	1	4	0	4	0	2	0	4	5	4			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:130410218G>A	uc004ewd.2	-	15	2851	c.2613C>T	c.(2611-2613)TTC>TTT	p.F871F	IGSF1_uc004ewe.3_Silent_p.F865F|IGSF1_uc004ewf.2_Silent_p.F851F	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	871	Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GTTTGGGGTAGAATTCTGAAA	0.473													11	20					0	0	0	0	A	130410218	A	A	130410218	2	1	128	1	0	0	0	0	0	0	0	1	7635	933	33	2		2	IGSF1	23	130410218	Silent	SNP	G	TCGA-CR-6481-01A-11D-1870-08	7872913	130410218	24860342	560	23174											
GABRA3	2556	broad.mit.edu	37	chrX	151366158	151366158	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagccagaacgacacttgtGacagaatgacagtcatgata	15	8	10	8	1	1	6	1	4	0	2	1	7	1	6	1	0	2	0	1	0	3	2			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:151366158G>C	uc010ntk.1	-	8	1118	c.878C>G	c.(877-879)TCA>TGA	p.S293*		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	293	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CGACACTTGTGACAGAATGAC	0.453													12	34					0	0	0	0	C	151366158	C	C	151366158	4	2	128	1	0	0	0	0	0	1	0	0	6196	1294	45	2	612	2	GABRA3	23	151366158	Nonsense_Mutation	SNP	G	TCGA-CR-6481-01A-11D-1870-08	20955940	151366158	3904402	561	23175											
FBXO44	93611	broad.mit.edu	37	chr1	11718436	11718436	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaccaggtcaagaaatacttCgttacttcatattagtaaga	15	12	7	7	1	2	2	2	0	0	2	3	3	2	2	1	1	2	2	1	1	7	7			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:11718436C>T	uc001asm.2	+	3	504	c.378C>T	c.(376-378)TTC>TTT	p.F126F	FBXO44_uc001ask.2_Intron|FBXO44_uc010oaq.1_Silent_p.F126F|FBXO44_uc001asl.2_Silent_p.F126F|FBXO44_uc001asn.2_Intron|FBXO44_uc010oar.1_Intron|FBXO44_uc010oas.1_Intron	NM_033182	NP_149438	Q9H4M3	FBX44_HUMAN	F-box protein 44 isoform 1	126	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		AGAAATACTTCGTTACTTCAT	0.527													28	81					0	0	0	0	T	11718436	T	T	11718436	2	4	129	1	0	0	0	0	0	0	0	1	5785	883	31	1		1	FBXO44	1	11718436	Silent	SNP	C	TCGA-CR-6482-01A-11D-1870-08		11718436	237532185	1	23176											
JAK1	3716	broad.mit.edu	37	chr1	65332750	65332750	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatttcaccttcaggtcatgCgtggacacgctgctgtcaca	8	12	9	12	2	4	0	4	0	0	0	4	1	4	1	1	2	2	2	1	2	1	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:65332750C>T	uc001dbu.1	-	7	1038	c.789G>A	c.(787-789)ACG>ACA	p.T263T	JAK1_uc009wam.1_Silent_p.T251T	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	263	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TCAGGTCATGCGTGGACACGC	0.398			Mis		ALL								4	144					0	0	0	0	T	65332750	T	T	65332750	2	4	129	1	0	0	0	0	0	0	0	1	7976	755	27	1		1	JAK1	1	65332750	Silent	SNP	C	TCGA-CR-6482-01A-11D-1870-08	53614314	65332750	183917871	2	23177											
CSF1	1435	broad.mit.edu	37	chr1	110466699	110466699	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggccatgagaggcagtccGagggatccttcagcccgcag	9	5	14	13	2	1	1	1	1	0	1	3	4	3	2	4	3	1	2	4	3	0	1			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:110466699G>A	uc001dyu.2	+	6	1869	c.1456G>A	c.(1456-1458)GAG>AAG	p.E486K	CSF1_uc001dyt.2_Missense_Mutation_p.E370K|CSF1_uc001dyv.3_Missense_Mutation_p.E188K|CSF1_uc001dyw.3_Missense_Mutation_p.E486K	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	486	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		GAGGCAGTCCGAGGGATCCTT	0.612													20	61					0	0	0	0	A	110466699	A	A	110466699	3	1	129	1	0	0	0	0	1	0	0	0	3948	1059	37	1	1478	1	CSF1	1	110466699	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	45133949	110466699	138783922	3	23178											
HRNR	388697	broad.mit.edu	37	chr1	152188507	152188507	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccaaatccagaagactgAcctgagccagacccatgtcg	13	6	9	13	1	0	6	0	3	0	3	2	6	1	6	5	0	1	0	5	0	2	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:152188507A>T	uc001ezt.1	-	3	5674	c.5598T>A	c.(5596-5598)GGT>GGA	p.G1866G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1866	20.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGAAGACTGACCTGAGCCAG	0.582													39	669					0	0	0	0	T	152188507	T	T	152188507	2	4	129	1	0	0	0	0	0	0	0	1	7398	262	10	5		5	HRNR	1	152188507	Silent	SNP	A	TCGA-CR-6482-01A-11D-1870-08	41721808	152188507	97062114	4	23179											
TRIM46	80128	broad.mit.edu	37	chr1	155152367	155152367	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaacaaggccggctacggCgaatacagtgaagatgtgca	13	6	13	9	3	0	2	0	1	0	1	0	3	0	2	1	3	5	3	1	3	6	2			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:155152367C>T	uc001fhs.1	+	8	1628	c.1545C>T	c.(1543-1545)GGC>GGT	p.G515G	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Silent_p.G515G|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Silent_p.G389G|TRIM46_uc001fhu.1_Silent_p.G492G|TRIM46_uc009wpg.1_Silent_p.G502G|TRIM46_uc001fhv.3_Silent_p.G502G|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	515	Fibronectin type-III.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCGGCTACGGCGAATACAGTG	0.657													8	25					0	0	0	0	T	155152367	T	T	155152367	2	4	129	1	0	0	0	0	0	0	0	1	16588	755	27	1		1	TRIM46	1	155152367	Silent	SNP	C	TCGA-CR-6482-01A-11D-1870-08	2963860	155152367	94098254	5	23180											
ISG20L2	81875	broad.mit.edu	37	chr1	156696882	156696882	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	catgcccctttggtcctgtgCccaccatctcacagtcaatt	7	12	6	16	0	2	0	2	0	1	0	4	0	3	0	5	1	2	0	5	1	1	2			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:156696882C>T	uc001fps.1	-	1	824	c.563G>A	c.(562-564)GGC>GAC	p.G188D	ISG20L2_uc001fpt.1_Missense_Mutation_p.G188D|C1orf66_uc001fpu.2_5'Flank|C1orf66_uc001fpv.2_5'Flank	NM_030980	NP_112242	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene	188	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGTCCTGTGCCCACCATCTC	0.517											OREG0013885	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	164					0	0	0	0	T	156696882	T	T	156696882	3	4	129	1	0	0	0	0	1	0	0	0	7894	739	26	4	510	4	ISG20L2	1	156696882	Missense_Mutation	SNP	C	TCGA-CR-6482-01A-11D-1870-08	1544515	156696882	92553739	6	23181											
FAM58B	339521	broad.mit.edu	37	chr1	200183318	200183318	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccctgcaggtctatggagtCgaggtgcccgccgaggtcga	6	7	16	12	4	1	0	0	0	1	0	3	4	1	1	3	4	2	1	3	4	1	1			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr1:200183318C>T	uc009wzi.1	+	1	663	c.627C>T	c.(625-627)GTC>GTT	p.V209V		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	209					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					TCTATGGAGTCGAGGTGCCCG	0.597													7	39					0	0	0	0	T	200183318	T	T	200183318	2	4	129	1	0	0	0	0	0	0	0	1	5623	871	31	1		1	FAM58B	1	200183318	Silent	SNP	C	TCGA-CR-6482-01A-11D-1870-08	43486436	200183318	49067303	7	23182											
RASGRP3	25780	broad.mit.edu	37	chr2	33764264	33764264	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtcatcaacaagcacataaGgaaattagtggaggtaagtg	16	8	12	5	0	2	0	2	0	0	0	2	2	2	2	0	4	2	2	0	4	6	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr2:33764264G>T	uc002rox.2	+	13	1892	c.1265G>T	c.(1264-1266)AGG>ATG	p.R422M	RASGRP3_uc010ync.1_Missense_Mutation_p.R422M|RASGRP3_uc002roy.2_Missense_Mutation_p.R421M	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	422	EF-hand 1.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					AAGCACATAAGGAAATTAGTG	0.517													3	10					0.00909568	0.00949696	1	0	T	33764264	T	T	33764264	3	4	129	1	0	0	0	0	1	0	0	0	13141	1000	35	4	1303	4	RASGRP3	2	33764264	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		33764264	209435109	8	23183											
LOC728819	728819	broad.mit.edu	37	chr2	43902588	43902588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtccaaatgccctgagccGgtacaggccatacatcatta	11	9	9	12	1	1	1	1	1	0	0	2	1	2	1	4	2	4	1	4	2	4	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr2:43902588G>A	uc010fav.1	-	1	874	c.874C>T	c.(874-876)CGG>TGG	p.R292W	PLEKHH2_uc002rte.3_Intron|PLEKHH2_uc002rtf.3_Intron|PLEKHH2_uc010yny.1_Intron	NM_001101330	NP_001094800			C1GALT1-specific chaperone 1-like												0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCCCTGAGCCGGTACAGGCCA	0.453													4	51					0	0	0	0	A	43902588	A	A	43902588	3	1	129	1	0	0	0	0	1	0	0	0	8937	1115	39	1	77	1	LOC728819	2	43902588	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	10138324	43902588	199296785	9	23184											
ZFYVE20	64145	broad.mit.edu	37	chr3	15115677	15115677	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gattgtactctttcaggatgCgggctgaagggtctaaggaa	10	11	14	6	1	3	1	1	1	2	0	3	4	3	3	0	4	2	2	0	4	4	4	rs147577833	byFrequency	TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:15115677C>T	uc003bzm.1	-	14	2581	c.1967G>A	c.(1966-1968)CGC>CAC	p.R656H	ZFYVE20_uc010hek.1_Missense_Mutation_p.R656H	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	656	Necessary for the interaction with RAB5A.|Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						TTTCAGGATGCGGGCTGAAGG	0.562													4	102					0	0	0	0	T	15115677	T	T	15115677	3	4	129	1	0	0	0	0	1	0	0	0	17733	768	27	1	391	1	ZFYVE20	3	15115677	Missense_Mutation	SNP	C	TCGA-CR-6482-01A-11D-1870-08		15115677	182906753	10	23185											
UBA3	9039	broad.mit.edu	37	chr3	69111272	69111272	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcaacatccttacatacTcaatacagtgttctggtagc	12	12	6	11	0	2	0	1	0	1	0	3	0	3	0	1	1	6	3	1	1	6	5			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:69111272T>A	uc003dno.2	-	10	772	c.752A>T	c.(751-753)GAG>GTG	p.E251V	UBA3_uc003dnq.2_Missense_Mutation_p.E237V|UBA3_uc011bfy.1_Missense_Mutation_p.E74V|UBA3_uc011bfz.1_Missense_Mutation_p.E74V	NM_003968	NP_003959	Q8TBC4	UBA3_HUMAN	ubiquitin-activating enzyme 3 isoform 1	251					protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		CCTTACATACTCAATACAGTG	0.343													20	74					0	0	0	0	A	69111272	A	A	69111272	3	1	129	1	0	0	0	0	1	0	0	0	16897	1551	54	5	675	5	UBA3	3	69111272	Missense_Mutation	SNP	T	TCGA-CR-6482-01A-11D-1870-08	53995595	69111272	128911158	11	23186											
POLQ	10721	broad.mit.edu	37	chr3	121208235	121208235	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatggtgtttcatataaacAttctggttttttgaaccatt	10	19	6	6	0	3	1	2	1	1	0	3	1	3	1	1	2	2	2	1	2	4	8			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:121208235A>G	uc003eee.3	-	16	3672	c.3543T>C	c.(3541-3543)AAT>AAC	p.N1181N	POLQ_uc003eed.2_Silent_p.N353N	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1181					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TCATATAAACATTCTGGTTTT	0.378								DNA_polymerases_(catalytic_subunits)					7	204					0	0	0	0	G	121208235	G	G	121208235	2	3	129	1	0	0	0	0	0	0	0	1	12263	214	8	5		5	POLQ	3	121208235	Silent	SNP	A	TCGA-CR-6482-01A-11D-1870-08	52096963	121208235	76814195	12	23187											
KALRN	8997	broad.mit.edu	37	chr3	124103747	124103747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagagcagttggctcagaCgggggaatgtgaccccgagg	10	5	17	9	2	1	3	1	1	0	2	1	5	1	4	2	4	2	4	2	4	1	1			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:124103747C>T	uc003ehg.2	+	11	1947	c.1820C>T	c.(1819-1821)ACG>ATG	p.T607M	KALRN_uc010hrv.1_Missense_Mutation_p.T607M|KALRN_uc003ehf.1_Missense_Mutation_p.T607M|KALRN_uc011bjy.1_Missense_Mutation_p.T607M|KALRN_uc003ehh.1_Translation_Start_Site	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	607	Spectrin 3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TTGGCTCAGACGGGGGAATGT	0.577													7	53					0	0	0	0	T	124103747	T	T	124103747	3	4	129	1	0	0	0	0	1	0	0	0	8014	536	19	1	1862	1	KALRN	3	124103747	Missense_Mutation	SNP	C	TCGA-CR-6482-01A-11D-1870-08	2895512	124103747	73918683	13	23188											
NCK1	4690	broad.mit.edu	37	chr3	136664745	136664745	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagaaattagcagcagtcGtcaataacctaaatactggg	16	8	9	8	1	1	1	1	0	0	1	2	2	1	1	1	1	4	2	1	1	7	4	rs149750260		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr3:136664745G>A	uc003erh.2	+	3	654	c.547G>A	c.(547-549)GTC>ATC	p.V183I	NCK1_uc011bme.1_Missense_Mutation_p.V119I	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	183					axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1						AGCAGCAGTCGTCAATAACCT	0.428													27	114					0	0	0	0	A	136664745	A	A	136664745	3	1	129	1	0	0	0	0	1	0	0	0	10273	1145	40	1	553	1	NCK1	3	136664745	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	12560998	136664745	61357685	14	23189											
TUBB4Q	56604	broad.mit.edu	37	chr4	190905409	190905409	+	Splice_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcctcgcccgcagctcaCgggaaatgaagttgtctggc	8	8	12	13	3	2	1	1	1	1	0	4	2	3	2	2	2	1	3	2	2	2	1			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr4:190905409C>T	uc011clg.1	-	3	277	c.274_splice	c.e3+1	p.R92_splice		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q						'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		CCGCAGCTCACGGGAAATGAA	0.657													5	49					0	0	0	0	T	190905409	T	T	190905409	5	4	129	1	0	0	0	0	0	0	1	0	16827	550	19	1	1033	1	TUBB4Q	4	190905409	Splice_Site	SNP	C	TCGA-CR-6482-01A-11D-1870-08		190905409	248867	15	23190											
TAF7	6879	broad.mit.edu	37	chr5	140698816	140698816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcattttcctggtgctgttCatctgattcatttagcttgt	5	21	7	8	0	4	1	3	1	1	0	5	1	5	1	1	1	2	3	1	1	1	8			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr5:140698816C>T	uc003ljg.2	-	1	1536	c.796G>A	c.(796-798)GAA>AAA	p.E266K		NM_005642	NP_005633	Q15545	TAF7_HUMAN	TATA box-binding protein-associated factor 2F	266	Potential.				negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGCTGTTCATCTGATTCA	0.448													32	125					0	0	0	0	T	140698816	T	T	140698816	3	4	129	1	0	0	0	0	1	0	0	0	15598	835	29	2	257	2	TAF7	5	140698816	Missense_Mutation	SNP	C	TCGA-CR-6482-01A-11D-1870-08		140698816	40216444	16	23191											
PCDH12	51294	broad.mit.edu	37	chr5	141325324	141325324	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgaggggcaaagagagtctCgccatccaggccgggtcagg	9	5	17	10	2	2	2	1	1	1	1	4	3	3	2	3	5	0	1	3	5	1	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr5:141325324C>T	uc003llx.2	-	4	4388	c.3177G>A	c.(3175-3177)GCG>GCA	p.A1059A		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	1059	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAGAGTCTCGCCATCCAGG	0.667													20	56					0	0	0	0	T	141325324	T	T	141325324	2	4	129	1	0	0	0	0	0	0	0	1	11564	871	31	1		1	PCDH12	5	141325324	Silent	SNP	C	TCGA-CR-6482-01A-11D-1870-08	626508	141325324	39589936	17	23192											
GFRAL	389400	broad.mit.edu	37	chr6	55223938	55223938	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catagaaaatcatgtttcagTaagttccccaaataaaatta	18	12	4	7	0	2	1	2	0	0	1	3	1	3	1	2	0	0	3	2	0	8	6			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr6:55223938T>C	uc003pcm.1	+	6	1038	c.952_splice	c.e6+2	p.N318_splice		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor							integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CATGTTTCAGTAAGTTCCCCA	0.284													8	41					0	0	0	0	C	55223938	C	C	55223938	5	2	129	1	0	0	0	0	0	0	1	0	6388	1652	57	5	976	5	GFRAL	6	55223938	Splice_Site	SNP	T	TCGA-CR-6482-01A-11D-1870-08		55223938	115891129	18	23193											
GPRC6A	222545	broad.mit.edu	37	chr6	117128262	117128262	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccaaccagatttctgaatCaggtgagccattgctttaat	11	14	7	9	0	2	3	1	2	1	1	3	3	3	3	3	1	3	1	3	1	3	5			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr6:117128262C>G	uc003pxj.1	-	3	628	c.606G>C	c.(604-606)CTG>CTC	p.L202L	GPRC6A_uc003pxk.1_Silent_p.L202L|GPRC6A_uc003pxl.1_Silent_p.L202L	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	202	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATTTCTGAATCAGGTGAGCCA	0.398													50	171					0	0	0	0	G	117128262	G	G	117128262	2	3	129	1	0	0	0	0	0	0	0	1	6767	813	29	2		2	GPRC6A	6	117128262	Silent	SNP	C	TCGA-CR-6482-01A-11D-1870-08	61904324	117128262	53986805	19	23194											
MYB	4602	broad.mit.edu	37	chr6	135510957	135510957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatgtgcagtgccagcaccGatggcagaaagtactaaacc	14	6	11	10	1	0	2	0	0	0	2	0	3	0	2	3	1	5	4	3	1	4	2			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr6:135510957G>A	uc003qfc.2	+	4	441	c.242G>A	c.(241-243)CGA>CAA	p.R81Q	MYB_uc003qfh.2_Missense_Mutation_p.R81Q|MYB_uc003qfi.2_Missense_Mutation_p.R81Q|MYB_uc010kgi.2_Missense_Mutation_p.R81Q|MYB_uc003qfq.2_Missense_Mutation_p.R81Q|MYB_uc010kgj.2_Missense_Mutation_p.R81Q|MYB_uc003qfo.2_Missense_Mutation_p.R81Q|MYB_uc003qfu.2_Missense_Mutation_p.R81Q|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_5'UTR|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_5'UTR|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Missense_Mutation_p.R81Q|MYB_uc003qgd.1_5'UTR	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	81	HTH myb-type 1.|H-T-H motif (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		TGCCAGCACCGATGGCAGAAA	0.398			T	NFIB	adenoid cystic carcinoma								16	98					0	0	0	0	A	135510957	A	A	135510957	3	1	129	1	0	0	0	0	1	0	0	0	10060	1058	37	1	256	1	MYB	6	135510957	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	18382695	135510957	35604110	20	23195											
KIAA1549	57670	broad.mit.edu	37	chr7	138601971	138601971	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttgagaacaaagaagactCagttaaaatgggcgttgtgt	15	10	12	4	1	1	3	1	1	0	3	1	4	1	3	0	1	1	3	0	1	5	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr7:138601971C>T	uc011kql.1	-	2	2450	c.2401G>A	c.(2401-2403)GAG>AAG	p.E801K	KIAA1549_uc003vuk.3_Missense_Mutation_p.E751K|KIAA1549_uc011kqj.1_Missense_Mutation_p.E801K	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	801						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						AAAGAAGACTCAGTTAAAATG	0.512			O	BRAF	pilocytic astrocytoma								5	21					0	0	0	0	T	138601971	T	T	138601971	3	4	129	1	0	0	0	0	1	0	0	0	8283	835	29	2	3527	2	KIAA1549	7	138601971	Missense_Mutation	SNP	C	TCGA-CR-6482-01A-11D-1870-08		138601971	20536692	21	23196											
CSMD1	64478	broad.mit.edu	37	chr8	3076900	3076900	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccctggtaactcccaatgaGggggctgttggaatcttccc	7	10	12	12	0	1	1	0	1	1	0	3	2	3	2	3	4	1	3	3	4	3	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:3076900G>A	uc011kwk.1	-	29	4942	c.4552C>T	c.(4552-4554)CTC>TTC	p.L1518F	CSMD1_uc011kwj.1_Missense_Mutation_p.L910F|CSMD1_uc003wqe.2_Missense_Mutation_p.L674F	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1518	Extracellular (Potential).|CUB 9.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCCCAATGAGGGGGCTGTTG	0.478													3	3					0	0	0	0	A	3076900	A	A	3076900	3	1	129	1	0	0	0	0	1	0	0	0	3961	1000	35	4	6313	4	CSMD1	8	3076900	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		3076900	143287122	22	23197											
ARC	23237	broad.mit.edu	37	chr8	143695621	143695621	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcccgccgctggtccggtgGtccagctccatctgtgcgca	4	8	13	16	4	1	0	0	0	1	0	4	0	4	0	5	3	3	3	5	3	0	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:143695621G>A	uc003ywn.1	-	1	213	c.12C>T	c.(10-12)GAC>GAT	p.D4D		NM_015193	NP_056008	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated	4					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)	1	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				TGGTCCGGTGGTCCAGCTCCA	0.746													4	10					0	0	0	0	A	143695621	A	A	143695621	2	1	129	1	0	0	0	0	0	0	0	1	841	1252	44	4		4	ARC	8	143695621	Silent	SNP	G	TCGA-CR-6482-01A-11D-1870-08	140618721	143695621	2668401	23	23198											
NRBP2	340371	broad.mit.edu	37	chr8	144919254	144919254	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctctggcgtcggggtcttgGccttttggacctcctccggg	1	12	15	13	3	2	0	0	0	2	0	5	1	4	1	4	6	0	1	4	6	0	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:144919254G>A	uc011lkt.1	-	14	1360	c.1220C>T	c.(1219-1221)GCC>GTC	p.A407V	NRBP2_uc003yzv.2_Missense_Mutation_p.A164V|NRBP2_uc003yzz.1_Missense_Mutation_p.A25V|NRBP2_uc003yzw.2_Missense_Mutation_p.A199V|NRBP2_uc010mfl.2_Missense_Mutation_p.A199V|NRBP2_uc010mfm.2_Missense_Mutation_p.A164V|NRBP2_uc011lks.1_Missense_Mutation_p.A164V|NRBP2_uc003yzy.2_Missense_Mutation_p.A164V	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	407					negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CGGGGTCTTGGCCTTTTGGAC	0.607													42	103					0	0	0	0	A	144919254	A	A	144919254	3	1	129	1	0	0	0	0	1	0	0	0	10697	1203	42	4	305	4	NRBP2	8	144919254	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	1223633	144919254	1444768	24	23199											
PLEC	5339	broad.mit.edu	37	chr8	144998170	144998170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgccgctcctcctccgccGccagctgccgctgcctcgca	2	6	10	23	6	0	0	0	0	0	0	4	0	3	0	9	0	3	4	9	0	0	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr8:144998170G>A	uc003zaf.1	-	31	6508	c.6338C>T	c.(6337-6339)GCG>GTG	p.A2113V	PLEC_uc003zab.1_Missense_Mutation_p.A1976V|PLEC_uc003zac.1_Missense_Mutation_p.A1980V|PLEC_uc003zad.2_Missense_Mutation_p.A1976V|PLEC_uc003zae.1_Missense_Mutation_p.A1944V|PLEC_uc003zag.1_Missense_Mutation_p.A1954V|PLEC_uc003zah.2_Missense_Mutation_p.A1962V|PLEC_uc003zaj.2_Missense_Mutation_p.A2003V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2113	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTCCTCCGCCGCCAGCTGCCG	0.741													8	7					0	0	0	0	A	144998170	A	A	144998170	3	1	129	1	0	0	0	0	1	0	0	0	12107	1087	38	1	7724	1	PLEC	8	144998170	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	78916	144998170	1365852	25	23200											
LRSAM1	90678	broad.mit.edu	37	chr9	130259572	130259572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgcagcacgagatcctccGgagagtccaggaactgctgg	9	6	13	13	2	0	2	0	0	0	2	3	5	3	3	4	3	4	3	4	3	1	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr9:130259572G>A	uc004brb.1	+	24	2216	c.1871G>A	c.(1870-1872)CGG>CAG	p.R624Q	LRSAM1_uc010mxk.1_Missense_Mutation_p.R597Q|LRSAM1_uc004brc.1_Missense_Mutation_p.R624Q|LRSAM1_uc004brd.1_Missense_Mutation_p.R624Q|LRSAM1_uc004bre.1_Missense_Mutation_p.R204Q|uc004brf.1_5'Flank|LRSAM1_uc004brg.1_Missense_Mutation_p.R55Q	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	624	SAM.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						GAGATCCTCCGGAGAGTCCAG	0.617													7	26					0	0	0	0	A	130259572	A	A	130259572	3	1	129	1	0	0	0	0	1	0	0	0	9093	1116	39	1	1957	1	LRSAM1	9	130259572	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		130259572	10953859	26	23201											
FIBCD1	84929	broad.mit.edu	37	chr9	133805083	133805083	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcagccggggcagctggtcGgccagcgtgtccagcagctc	6	5	16	14	3	0	0	0	0	0	0	3	0	1	0	3	4	6	5	3	4	0	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr9:133805083G>A	uc004bzz.2	-	2	668	c.423C>T	c.(421-423)GCC>GCT	p.A141A	FIBCD1_uc011mcc.1_Silent_p.A141A|FIBCD1_uc011mcd.1_Silent_p.A149A	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	141	Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		GCAGCTGGTCGGCCAGCGTGT	0.731													5	9					0	0	0	0	A	133805083	A	A	133805083	2	1	129	1	0	0	0	0	0	0	0	1	5916	1103	39	1		1	FIBCD1	9	133805083	Silent	SNP	G	TCGA-CR-6482-01A-11D-1870-08	3545511	133805083	7408348	27	23202											
DYDC2	84332	broad.mit.edu	37	chr10	82126495	82126495	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agaccatattcatgcaggagGacacaaacccccttgagaag	15	6	9	11	0	1	2	1	1	0	2	1	5	1	4	3	2	2	1	3	2	3	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:82126495G>A	uc001kca.1	+	5	702	c.322G>A	c.(322-324)GAC>AAC	p.D108N	DYDC2_uc001kbz.1_RNA|DYDC2_uc001kcb.1_Missense_Mutation_p.D108N	NM_032372	NP_115748	Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	108							protein binding				0			Colorectal(32;0.229)			CATGCAGGAGGACACAAACCC	0.438													4	147					0	0	0	0	A	82126495	A	A	82126495	3	1	129	1	0	0	0	0	1	0	0	0	4861	1174	41	2	332	2	DYDC2	10	82126495	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		82126495	53408252	28	23203											
WAPAL	23063	broad.mit.edu	37	chr10	88277386	88277386	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcttctacaattcggttTgtgctcttttctttcccaag	6	19	5	11	1	5	0	1	0	4	0	7	0	6	0	1	1	2	2	1	1	3	7			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:88277386T>C	uc001kdo.2	-	2	883	c.441A>G	c.(439-441)ACA>ACG	p.T147T	WAPAL_uc001kdn.2_Silent_p.T190T|WAPAL_uc009xsw.2_Silent_p.T147T|WAPAL_uc010qmh.1_Silent_p.T147T|WAPAL_uc010qmi.1_Silent_p.T184T|WAPAL_uc010qmj.1_Silent_p.T147T	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	147	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						CAATTCGGTTTGTGCTCTTTT	0.363													3	76					0	0	0	0	C	88277386	C	C	88277386	2	2	129	1	0	0	0	0	0	0	0	1	17316	1799	63	5		5	WAPAL	10	88277386	Silent	SNP	T	TCGA-CR-6482-01A-11D-1870-08	6150891	88277386	47257361	29	23204											
FAM178A	55719	broad.mit.edu	37	chr10	102689617	102689617	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaattttcagttacaatTgatgctattcctgatcatca	14	15	5	7	0	3	3	3	2	0	1	4	3	4	3	1	0	2	2	1	0	5	6			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:102689617T>G	uc001krt.3	+	8	2738	c.2196T>G	c.(2194-2196)ATT>ATG	p.I732M	FAM178A_uc001krs.2_Missense_Mutation_p.I732M	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	732											0						CAGTTACAATTGATGCTATTC	0.294													12	56					0	0	0	0	G	102689617	G	G	102689617	3	3	129	1	0	0	0	0	1	0	0	0	5531	1800	63	5	2226	5	FAM178A	10	102689617	Missense_Mutation	SNP	T	TCGA-CR-6482-01A-11D-1870-08	14412231	102689617	32845130	30	23205											
KNDC1	85442	broad.mit.edu	37	chr10	135015084	135015084	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcggatgtggactcggaCgcactgtcacggggaaactt	8	9	15	9	4	1	0	1	0	0	0	3	4	1	4	0	5	1	1	0	5	1	1	rs142572566		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr10:135015084C>T	uc001llz.1	+	17	3070	c.3069C>T	c.(3067-3069)GAC>GAT	p.D1023D	KNDC1_uc001lma.1_Silent_p.D958D|KNDC1_uc001lmb.1_Silent_p.D435D	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1023					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TGGACTCGGACGCACTGTCAC	0.627													13	55					0	0	0	0	T	135015084	T	T	135015084	2	4	129	1	0	0	0	0	0	0	0	1	8465	535	19	1		1	KNDC1	10	135015084	Silent	SNP	C	TCGA-CR-6482-01A-11D-1870-08	32325467	135015084	519663	31	23206											
C11orf46	120534	broad.mit.edu	37	chr11	30358279	30358279	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgccgctgtgaccgcaaGtggctgtatgagcaaattga	11	9	13	8	2	0	3	0	3	0	0	0	4	0	3	2	1	2	5	2	1	4	2			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr11:30358279G>T	uc001mso.1	+	4	884	c.720G>T	c.(718-720)AAG>AAT	p.K240N	C11orf46_uc001msp.2_5'Flank	NM_152316	NP_689529	Q8N8R7	CK046_HUMAN	hypothetical protein LOC120534	240											0						GTGACCGCAAGTGGCTGTATG	0.443													16	100					1.02788e-11	1.12277e-11	1	0	T	30358279	T	T	30358279	3	4	129	1	0	0	0	0	1	0	0	0	1649	1020	36	4	730	4	C11orf46	11	30358279	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		30358279	104648237	32	23207											
PRG2	5553	broad.mit.edu	37	chr11	57154973	57154973	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaacagatgaaaggaagtCttctgaggcagtgggctcga	13	7	15	6	1	2	3	0	2	2	1	3	6	2	5	0	4	1	2	0	4	3	1			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr11:57154973C>A	uc001njz.2	-	5	671	c.644G>T	c.(643-645)AGA>ATA	p.R215I	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.R215I|PRG2_uc001nkb.2_Missense_Mutation_p.R215I|PRG2_uc001nkd.2_Missense_Mutation_p.R204I|PRG2_uc001nkc.2_Missense_Mutation_p.R215I|PRG2_uc001nke.2_Missense_Mutation_p.R495I	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	215	C-type lectin.				defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	GAAAGGAAGTCTTCTGAGGCA	0.602													9	44					3.09899e-07	3.33376e-07	1	0	A	57154973	A	A	57154973	3	1	129	1	0	0	0	0	1	0	0	0	12541	913	32	2	28	2	PRG2	11	57154973	Missense_Mutation	SNP	C	TCGA-CR-6482-01A-11D-1870-08	26796694	57154973	77851543	33	23208											
PRICKLE1	144165	broad.mit.edu	37	chr12	42866219	42866219	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcccggggggacccaggCgtactcctccaatgcacagc	8	4	13	16	2	0	0	0	0	0	0	2	1	2	1	4	5	3	2	4	5	2	1			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:42866219C>T	uc010skv.1	-	2	387	c.100G>A	c.(100-102)GCC>ACC	p.A34T	PRICKLE1_uc001rnl.2_Missense_Mutation_p.A34T|PRICKLE1_uc010skw.1_Missense_Mutation_p.A34T|PRICKLE1_uc001rnm.2_Missense_Mutation_p.A34T|PRICKLE1_uc009zka.2_Missense_Mutation_p.A30T	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	34	PET.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GGGACCCAGGCGTACTCCTCC	0.478													11	43					0	0	0	0	T	42866219	T	T	42866219	3	4	129	1	0	0	0	0	1	0	0	0	12548	768	27	1	2423	1	PRICKLE1	12	42866219	Missense_Mutation	SNP	C	TCGA-CR-6482-01A-11D-1870-08		42866219	90985676	34	23209											
PA2G4	5036	broad.mit.edu	37	chr12	56504766	56504766	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagcatttgaagatgagaaGaaggctcggatgggtgtggt	12	9	17	3	1	0	5	0	2	0	4	1	7	0	6	0	4	1	2	0	4	3	1			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:56504766G>C	uc001sjm.2	+	10	1280	c.861G>C	c.(859-861)AAG>AAC	p.K287N	PA2G4_uc009zol.2_Missense_Mutation_p.K287N|PA2G4_uc009zom.2_Intron	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	287					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			AAGATGAGAAGAAGGCTCGGA	0.428													7	39					0	0	0	0	C	56504766	C	C	56504766	3	2	129	1	0	0	0	0	1	0	0	0	11415	933	33	2	899	2	PA2G4	12	56504766	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	13638547	56504766	77347129	35	23210											
PA2G4	5036	broad.mit.edu	37	chr12	56505295	56505295	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgcaagtcgaaaaacccaGaaaaagaaaaaaaagaaggt	23	4	8	6	1	1	3	0	0	1	3	2	4	1	3	1	1	2	1	1	1	10	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:56505295G>C	uc001sjm.2	+	12	1520	c.1101G>C	c.(1099-1101)CAG>CAC	p.Q367H	PA2G4_uc009zol.2_Intron|PA2G4_uc009zom.2_Intron	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	367	Necessary for nucleolar localization.|Interaction with RNA (By similarity).				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			GAAAAACCCAGAAAAAGAAAA	0.393													22	104					0	0	0	0	C	56505295	C	C	56505295	3	2	129	1	0	0	0	0	1	0	0	0	11415	933	33	2	1147	2	PA2G4	12	56505295	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	529	56505295	77346600	36	23211											
CHST11	50515	broad.mit.edu	37	chr12	105151235	105151235	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggacgatgtcaaattcgAggagtttgtggcctatctca	10	11	13	7	2	2	0	2	0	1	0	4	4	2	2	1	4	0	1	1	4	2	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr12:105151235A>G	uc001tkx.1	+	4	1004	c.713A>G	c.(712-714)GAG>GGG	p.E238G	CHST11_uc001tky.2_Missense_Mutation_p.E233G|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	238	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						GTCAAATTCGAGGAGTTTGTG	0.567													20	57					0	0	0	0	G	105151235	G	G	105151235	3	3	129	1	0	0	0	0	1	0	0	0	3414	304	11	5	723	5	CHST11	12	105151235	Missense_Mutation	SNP	A	TCGA-CR-6482-01A-11D-1870-08	48645940	105151235	28700660	37	23212											
PABPC3	5042	broad.mit.edu	37	chr13	25670487	25670487	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggacttgatcaccagcggcTcctccaactacgcgtatgtg	8	9	11	13	3	1	1	1	1	0	0	3	2	3	2	3	2	3	2	3	2	3	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr13:25670487T>C	uc001upy.2	+	1	212	c.151T>C	c.(151-153)TCC>CCC	p.S51P		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	51	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CACCAGCGGCTCCTCCAACTA	0.562													12	53					0	0	0	0	C	25670487	C	C	25670487	3	2	129	1	0	0	0	0	1	0	0	0	11419	1551	54	5	153	5	PABPC3	13	25670487	Missense_Mutation	SNP	T	TCGA-CR-6482-01A-11D-1870-08		25670487	89499391	38	23213											
NID2	22795	broad.mit.edu	37	chr14	52473375	52473375	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgtacactccagttttttgGttccttttaaaacaaagggg	10	15	9	7	0	0	0	0	0	0	0	2	0	2	0	2	3	2	3	2	3	4	7			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr14:52473375G>A	uc001wzo.2	-	20	4118	c.3884C>T	c.(3883-3885)ACC>ATC	p.T1295I	NID2_uc010tqs.1_Missense_Mutation_p.T1247I|NID2_uc010tqt.1_Missense_Mutation_p.T1295I	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1295	LDL-receptor class B 4.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CAGTTTTTTGGTTCCTTTTAA	0.428													13	90					0	0	0	0	A	52473375	A	A	52473375	3	1	129	1	0	0	0	0	1	0	0	0	10469	1261	44	4	255	4	NID2	14	52473375	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		52473375	54876165	39	23214											
RYR3	6263	broad.mit.edu	37	chr15	34150099	34150099	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacgagcccgatatgaagtGcgacgacatgatgacggtga	12	7	14	8	5	0	5	0	5	0	0	0	9	0	5	1	1	2	0	1	1	2	1			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:34150099G>A	uc001zhi.2	+	99	14196	c.14126G>A	c.(14125-14127)TGC>TAC	p.C4709Y	RYR3_uc010bar.2_Missense_Mutation_p.C4704Y	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4709				C -> R (in Ref. 6; CAA52326).	cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GATATGAAGTGCGACGACATG	0.592													6	41					0	0	0	0	A	34150099	A	A	34150099	3	1	129	1	0	0	0	0	1	0	0	0	13835	1319	46	4	14520	4	RYR3	15	34150099	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		34150099	68381293	40	23215											
VPS18	57617	broad.mit.edu	37	chr15	41191580	41191580	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcggccctgctccggatctCtacttccgcccattgtacgt	4	13	8	16	4	1	0	0	0	1	0	5	1	3	1	4	2	3	2	4	2	2	5			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:41191580C>G	uc001zne.2	+	4	903	c.564C>G	c.(562-564)CTC>CTG	p.L188L		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	188					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CTCCGGATCTCTACTTCCGCC	0.602													14	72					0	0	0	0	G	41191580	G	G	41191580	2	3	129	1	0	0	0	0	0	0	0	1	17262	900	32	2		2	VPS18	15	41191580	Silent	SNP	C	TCGA-CR-6482-01A-11D-1870-08	7041481	41191580	61339812	41	23216											
MAP1A	4130	broad.mit.edu	37	chr15	43816968	43816968	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacaggataaagcaatagtCtttgagattatggaggcagg	14	9	13	5	0	1	1	0	1	1	1	1	4	1	3	0	4	1	3	0	4	5	4			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:43816968C>A	uc001zrt.2	+	4	3764	c.3297C>A	c.(3295-3297)GTC>GTA	p.V1099V		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1099						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AAGCAATAGTCTTTGAGATTA	0.547													18	76					4.54149e-19	5.11818e-19	1	0	A	43816968	A	A	43816968	2	1	129	1	0	0	0	0	0	0	0	1	9280	900	32	2		2	MAP1A	15	43816968	Silent	SNP	C	TCGA-CR-6482-01A-11D-1870-08	2625388	43816968	58714424	42	23217											
LRRK1	79705	broad.mit.edu	37	chr15	101589973	101589973	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accacgtcaattccttgattGatcagtggtttcccggtaag	9	13	9	10	2	2	2	2	2	0	0	4	2	4	2	3	2	0	2	3	2	2	5			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr15:101589973G>A	uc002bwr.2	+	23	3743	c.3424G>A	c.(3424-3426)GAT>AAT	p.D1142N	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1142					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTCCTTGATTGATCAGTGGTT	0.463													11	43					0	0	0	0	A	101589973	A	A	101589973	3	1	129	1	0	0	0	0	1	0	0	0	9082	1290	45	2	3510	2	LRRK1	15	101589973	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	57773005	101589973	941419	43	23218											
TPSD1	23430	broad.mit.edu	37	chr16	1306807	1306807	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgctgcccagggacatcaaGgatctggccgccctcagggt	7	6	13	15	2	3	0	2	0	1	0	3	2	3	2	4	4	1	1	4	4	1	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr16:1306807G>C	uc002clb.1	+	3	273	c.264G>C	c.(262-264)AAG>AAC	p.K88N	TPSD1_uc010brm.1_Intron	NM_012217	NP_036349	Q9BZJ3	TRYD_HUMAN	tryptase delta 1 precursor	88	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GGGACATCAAGGATCTGGCCG	0.667													3	25					0	0	0	0	C	1306807	C	C	1306807	3	2	129	1	0	0	0	0	1	0	0	0	16492	991	35	4	274	4	TPSD1	16	1306807	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		1306807	89047946	44	23219											
MYO15A	51168	broad.mit.edu	37	chr17	18057108	18057108	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctctgccctcgcgatcgctGgagccccctgaggaactcac	6	7	11	17	3	2	1	1	1	1	0	4	4	2	3	3	2	3	2	3	2	1	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr17:18057108G>A	uc010vxh.1	+	42	8324	c.7986G>A	c.(7984-7986)CTG>CTA	p.L2662L	MYO15A_uc010vxi.1_5'UTR|MYO15A_uc010vxj.1_5'Flank|MYO15A_uc010vxk.1_5'Flank	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2662	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CGCGATCGCTGGAGCCCCCTG	0.512													4	33					0	0	0	0	A	18057108	A	A	18057108	2	1	129	1	0	0	0	0	0	0	0	1	10116	1335	47	4		4	MYO15A	17	18057108	Silent	SNP	G	TCGA-CR-6482-01A-11D-1870-08		18057108	63138102	45	23220											
TANC2	26115	broad.mit.edu	37	chr17	61391920	61391920	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccaaggagtagtgattgtggGaaacattggattcggcaaaa	14	9	13	5	1	0	1	0	1	0	0	1	4	0	4	1	4	1	2	1	4	5	4			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr17:61391920G>A	uc002jal.3	+	8	1132	c.1109G>A	c.(1108-1110)GGA>GAA	p.G370E	TANC2_uc010wpe.1_Missense_Mutation_p.G280E	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	370							binding			ovary(2)	2						GTGATTGTGGGAAACATTGGA	0.498													21	90					0	0	0	0	A	61391920	A	A	61391920	3	1	129	1	0	0	0	0	1	0	0	0	15611	1174	41	2	1139	2	TANC2	17	61391920	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	43334812	61391920	19803290	46	23221											
FASN	2194	broad.mit.edu	37	chr17	80045301	80045301	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtacaggccgtgcttggcCgagcccaggatggacatctg	8	7	15	11	2	1	0	0	0	1	0	1	3	1	2	3	5	3	2	3	5	1	2	rs146226779		TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr17:80045301C>T	uc002kdu.2	-	20	3240	c.3123G>A	c.(3121-3123)TCG>TCA	p.S1041S	FASN_uc002kdw.1_Silent_p.S257S	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	1041					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CGTGCTTGGCCGAGCCCAGGA	0.622													10	50					0	0	0	0	T	80045301	T	T	80045301	2	4	129	1	0	0	0	0	0	0	0	1	5715	639	23	1		1	FASN	17	80045301	Silent	SNP	C	TCGA-CR-6482-01A-11D-1870-08	18653381	80045301	1149909	47	23222											
LRRC30	339291	broad.mit.edu	37	chr18	7231177	7231177	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggccagctccaaggataaggGccccaagaggatgctgttca	11	6	13	11	0	1	1	1	0	0	1	2	3	2	3	4	4	2	3	4	4	3	2			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr18:7231177G>A	uc010wzk.1	+	1	41	c.41G>A	c.(40-42)GGC>GAC	p.G14D		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	14										ovary(1)|liver(1)	2						AAGGATAAGGGCCCCAAGAGG	0.632													11	73					0	0	0	0	A	7231177	A	A	7231177	3	1	129	1	0	0	0	0	1	0	0	0	9035	1203	42	4	43	4	LRRC30	18	7231177	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		7231177	70846071	48	23223											
MPPE1	65258	broad.mit.edu	37	chr18	11893497	11893497	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccacttcccttcatcaaaGatatcccccaggatgaagac	12	9	5	15	0	2	3	2	1	0	2	5	4	5	4	4	1	0	0	4	1	3	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr18:11893497G>T	uc002kqf.2	-	4	1001	c.360C>A	c.(358-360)ATC>ATA	p.I120I	MPPE1_uc002kqn.2_Silent_p.I120I|MPPE1_uc002kqg.2_RNA|MPPE1_uc002kqh.2_RNA|MPPE1_uc002kqi.2_RNA|MPPE1_uc002kqj.2_Silent_p.I120I|MPPE1_uc002kqk.2_Silent_p.I120I|MPPE1_uc002kql.2_Silent_p.I120I|MPPE1_uc002kqm.2_Silent_p.I120I|MPPE1_uc010dla.1_Silent_p.I120I	NM_023075	NP_075563	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1 precursor	120					ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0						CTTCATCAAAGATATCCCCCA	0.537													17	32					1.56452e-12	1.73564e-12	1	0	T	11893497	T	T	11893497	2	4	129	1	0	0	0	0	0	0	0	1	9793	932	33	2		2	MPPE1	18	11893497	Silent	SNP	G	TCGA-CR-6482-01A-11D-1870-08	4662320	11893497	66183751	49	23224											
CYP4F12	66002	broad.mit.edu	37	chr19	15807840	15807840	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagctggaattgatcatgcGcgccgagggcgggctttggc	7	8	17	9	4	1	1	1	1	0	0	1	4	1	2	1	4	2	2	1	4	2	2			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:15807840G>A	uc002nbl.2	+	13	1581	c.1520G>A	c.(1519-1521)CGC>CAC	p.R507H		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					TTGATCATGCGCGCCGAGGGC	0.562													9	41					0	0	0	0	A	15807840	A	A	15807840	3	1	129	1	0	0	0	0	1	0	0	0	4204	1087	38	1	1566	1	CYP4F12	19	15807840	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		15807840	43321143	50	23225											
GNG8	94235	broad.mit.edu	37	chr19	47137457	47137457	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagttccgctgctgcctgcGacacctgcgagcacccgggt	5	7	14	15	4	0	0	0	0	0	0	1	3	1	1	4	2	5	4	4	2	0	1			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:47137457G>T	uc010xyd.1	-	2	89	c.89C>A	c.(88-90)TCG>TAG	p.S30*		NM_033258	NP_150283	Q9UK08	GBG8_HUMAN	guanine nucleotide binding protein (G protein),	30					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity				0		Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.000621)|Epithelial(262;0.0171)|GBM - Glioblastoma multiforme(486;0.0325)		TGCTGCCTGCGACACCTGCGA	0.677													6	11					0.00198382	0.00210226	1	0	T	47137457	T	T	47137457	4	4	129	1	0	0	0	0	0	1	0	0	6569	1059	37	3	126	3	GNG8	19	47137457	Nonsense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	31329617	47137457	11991526	51	23226											
GRIN2D	2906	broad.mit.edu	37	chr19	48922614	48922614	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccgcagcctggccacgggcaAgcgtgagtcccccttcctcc	5	6	11	19	3	0	1	0	1	0	0	3	1	3	1	7	2	2	2	7	2	1	1			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:48922614A>G	uc002pjc.3	+	8	1947	c.1859A>G	c.(1858-1860)AAG>AGG	p.K620R	GRIN2D_uc010elx.2_5'UTR	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	620	Cytoplasmic (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GCCACGGGCAAGCGTGAGTCC	0.597													7	31					0	0	0	0	G	48922614	G	G	48922614	3	3	129	1	0	0	0	0	1	0	0	0	6821	72	3	5	1885	5	GRIN2D	19	48922614	Missense_Mutation	SNP	A	TCGA-CR-6482-01A-11D-1870-08	1785157	48922614	10206369	52	23227											
ZNF543	125919	broad.mit.edu	37	chr19	57838010	57838010	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatgcacaggctgtccttTgttcaaaccagagctgatct	9	12	8	12	0	2	2	1	1	1	1	4	2	4	2	3	1	3	4	3	1	1	2			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr19:57838010T>C	uc002qoi.1	+	3	500	c.155T>C	c.(154-156)TTG>TCG	p.L52S		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGCTGTCCTTTGTTCAAACCA	0.493													10	51					0	0	0	0	C	57838010	C	C	57838010	3	2	129	1	0	0	0	0	1	0	0	0	18043	1821	63	5	165	5	ZNF543	19	57838010	Missense_Mutation	SNP	T	TCGA-CR-6482-01A-11D-1870-08	8915396	57838010	1290973	53	23228											
CHODL	140578	broad.mit.edu	37	chr21	19628972	19628972	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagccttgagaatgaagcaGaacagaagttaatagagagc	17	7	11	6	0	1	5	1	2	0	4	1	7	1	5	1	0	4	2	1	0	6	3			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr21:19628972G>C	uc002ykv.2	+	2	617	c.226G>C	c.(226-228)GAA>CAA	p.E76Q	CHODL_uc002ykr.2_Missense_Mutation_p.E35Q|CHODL_uc002yks.2_Missense_Mutation_p.E35Q|CHODL_uc002ykt.2_Missense_Mutation_p.E35Q|CHODL_uc002yku.2_Missense_Mutation_p.E35Q	NM_024944	NP_079220	Q9H9P2	CHODL_HUMAN	chondrolectin precursor	76	Extracellular (Potential).|C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			upper_aerodigestive_tract(1)	1		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		GAATGAAGCAGAACAGAAGTT	0.512													19	79					0	0	0	0	C	19628972	C	C	19628972	3	2	129	1	0	0	0	0	1	0	0	0	3379	943	33	2	232	2	CHODL	21	19628972	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08		19628972	28500923	54	23229											
PRODH	5625	broad.mit.edu	37	chr22	18906002	18906002	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtcacattgtcataggcAtcctgtggggccagggccaa	9	8	14	10	0	2	0	2	0	0	0	3	0	3	0	3	5	0	1	3	5	2	2			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr22:18906002A>C	uc010grl.2	-	11	1268	c.1254T>G	c.(1252-1254)GAT>GAG	p.D418E	PRODH_uc002zoj.3_Missense_Mutation_p.D308E|PRODH_uc002zol.3_Missense_Mutation_p.D308E|PRODH_uc002zok.3_Missense_Mutation_p.D418E	NM_016335	NP_057419	O43272	PROD_HUMAN	proline dehydrogenase 1	418					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)	1					L-Proline(DB00172)	TGTCATAGGCATCCTGTGGGG	0.662													3	21					0	0	0	0	C	18906002	C	C	18906002	3	2	129	1	0	0	0	0	1	0	0	0	12610	214	8	5	564	5	PRODH	22	18906002	Missense_Mutation	SNP	A	TCGA-CR-6482-01A-11D-1870-08		18906002	32398564	55	23230											
RGL4	266747	broad.mit.edu	37	chr22	24038844	24038844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggagaggaacccccagaGagtccagatgaggctgcgga	12	3	15	11	1	0	4	0	1	0	3	1	8	1	6	4	4	2	1	4	4	1	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr22:24038844G>A	uc002zxn.2	+	7	2300	c.1130G>A	c.(1129-1131)AGA>AAA	p.R377K	LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Missense_Mutation_p.R377K|RGL4_uc002zxp.1_Missense_Mutation_p.R241K|RGL4_uc002zxq.2_Missense_Mutation_p.R241K	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	377	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						AACCCCCAGAGAGTCCAGATG	0.652													7	26					0	0	0	0	A	24038844	A	A	24038844	3	1	129	1	0	0	0	0	1	0	0	0	13344	942	33	2	1156	2	RGL4	22	24038844	Missense_Mutation	SNP	G	TCGA-CR-6482-01A-11D-1870-08	5132842	24038844	27265722	56	23231											
CDC42EP1	11135	broad.mit.edu	37	chr22	37962716	37962716	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccatcatcaagaacgccatCtccctgccccagctcaacca	11	6	4	20	1	4	1	3	0	1	1	5	1	4	1	6	0	4	1	6	0	3	0			TCGA-CR-6482-01A-11D-1870-08	TCGA-CR-6482-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	684bcd80-30fb-49e5-b72a-09502a9d1468	b03408fe-f1c6-4276-9c02-1d783cc12fa5	g.chr22:37962716C>G	uc003asz.3	+	2	763	c.360C>G	c.(358-360)ATC>ATG	p.I120M		NM_152243	NP_689449	Q00587	BORG5_HUMAN	CDC42 effector protein 1	120					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding				0	Melanoma(58;0.0574)					AGAACGCCATCTCCCTGCCCC	0.692													16	82					0	0	0	0	G	37962716	G	G	37962716	3	3	129	1	0	0	0	0	1	0	0	0	3090	903	32	2	362	2	CDC42EP1	22	37962716	Missense_Mutation	SNP	C	TCGA-CR-6482-01A-11D-1870-08	13923872	37962716	13341850	57	23232											
NMNAT1	64802	broad.mit.edu	37	chr1	10032236	10032236	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagctggccaaggactacatGaatggaacaggtaggagcag	14	5	15	7	0	0	1	0	1	0	0	0	5	0	4	1	5	4	3	1	5	5	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:10032236G>C	uc001aqp.2	+	2	249	c.105G>C	c.(103-105)ATG>ATC	p.M35I		NM_022787	NP_073624	Q9HAN9	NMNA1_HUMAN	nicotinamide mononucleotide adenylyltransferase	35					water-soluble vitamin metabolic process	nucleoplasm	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding				0		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.31e-08)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(185;0.00028)|BRCA - Breast invasive adenocarcinoma(304;0.00032)|KIRC - Kidney renal clear cell carcinoma(229;0.00101)|STAD - Stomach adenocarcinoma(132;0.00908)|READ - Rectum adenocarcinoma(331;0.0419)		AGGACTACATGAATGGAACAG	0.343													29	150					0	0	0	0	C	10032236	C	C	10032236	3	2	130	1	0	0	0	0	1	0	0	0	10552	1290	45	2	107	2	NMNAT1	1	10032236	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08		10032236	239218385	1	23233											
FBLIM1	54751	broad.mit.edu	37	chr1	16101195	16101195	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggccaggccttccacccctCctgcttcacgtgtgtgacct	4	10	10	17	1	1	1	1	1	0	0	3	1	3	1	7	2	1	1	7	2	0	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:16101195C>T	uc001axd.1	+	8	1237	c.794C>T	c.(793-795)TCC>TTC	p.S265F	FBLIM1_uc001axe.1_Missense_Mutation_p.S265F|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axg.1_Missense_Mutation_p.S265F|FBLIM1_uc001axh.1_Missense_Mutation_p.S168F|FBLIM1_uc001axi.1_Missense_Mutation_p.S168F	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	265	LIM zinc-binding 2.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		TTCCACCCCTCCTGCTTCACG	0.632													10	95					0	0	0	0	T	16101195	T	T	16101195	3	4	130	1	0	0	0	0	1	0	0	0	5729	855	30	2	812	2	FBLIM1	1	16101195	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	6068959	16101195	233149426	2	23234											
SPEN	23013	broad.mit.edu	37	chr1	16259153	16259153	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatcatcccagttgaaaagtGatccagttgatccagacaag	14	10	8	9	0	1	4	1	3	0	1	4	4	4	4	3	0	0	2	3	0	4	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:16259153G>C	uc001axk.1	+	11	6622	c.6418G>C	c.(6418-6420)GAT>CAT	p.D2140H	SPEN_uc010obp.1_Missense_Mutation_p.D2099H	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2140	Interaction with MSX2 (By similarity).				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GTTGAAAAGTGATCCAGTTGA	0.547													26	115					0	0	0	0	C	16259153	C	C	16259153	3	2	130	1	0	0	0	0	1	0	0	0	15104	1290	45	2	6460	2	SPEN	1	16259153	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	157958	16259153	232991468	3	23235											
IL28RA	163702	broad.mit.edu	37	chr1	24484051	24484051	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcccaagcagaggagccttCgcttgggaccagaggagccc	10	5	13	13	1	0	2	0	0	0	2	2	5	1	5	4	3	3	2	4	3	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:24484051C>T	uc001bis.2	-	7	1145	c.1132G>A	c.(1132-1134)GAA>AAA	p.E378K	IL28RA_uc001bir.2_Missense_Mutation_p.E349K|IL28RA_uc001bit.2_3'UTR|IL28RA_uc001biu.2_Missense_Mutation_p.E294K	NM_170743	NP_734464	Q8IU57	I28RA_HUMAN	interleukin 28 receptor, alpha isoform 1	378	Cytoplasmic (Potential).				cytokine-mediated signaling pathway|negative regulation of cell proliferation|regulation of defense response to virus by host	interleukin-28 receptor complex	protein binding|receptor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00117)|all_lung(284;0.00151)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.21e-24)|Colorectal(126;6.61e-08)|COAD - Colon adenocarcinoma(152;3.56e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00918)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.185)		GAGGAGCCTTCGCTTGGGACC	0.627													7	22					0	0	0	0	T	24484051	T	T	24484051	3	4	130	1	0	0	0	0	1	0	0	0	7723	893	31	1	434	1	IL28RA	1	24484051	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	8224898	24484051	224766570	4	23236											
SFN	2810	broad.mit.edu	37	chr1	27190100	27190100	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actactaccgctacctggccGaggtggccaccggtgacgac	8	6	12	15	4	0	1	0	1	0	0	0	3	0	1	5	4	3	1	5	4	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:27190100G>A	uc001bnc.1	+	1	468	c.397G>A	c.(397-399)GAG>AAG	p.E133K	uc010ofi.1_RNA	NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	133					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		CTACCTGGCCGAGGTGGCCAC	0.622													10	50					0	0	0	0	A	27190100	A	A	27190100	3	1	130	1	0	0	0	0	1	0	0	0	14224	1059	37	1	399	1	SFN	1	27190100	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2706049	27190100	222060521	5	23237											
SPOCD1	90853	broad.mit.edu	37	chr1	32257825	32257825	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	taggcactcacctgggccccCcaaagggcgcagcctggtgg	7	5	14	15	1	1	0	1	0	0	0	1	0	1	0	5	5	1	2	5	5	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:32257825C>T	uc001bts.1	-	15	3011	c.2953G>A	c.(2953-2955)GGG>AGG	p.G985R	SPOCD1_uc001btr.1_Missense_Mutation_p.G73R|SPOCD1_uc001btt.2_Missense_Mutation_p.G290R|SPOCD1_uc001btu.2_Missense_Mutation_p.G985R|SPOCD1_uc001btv.2_Missense_Mutation_p.G478R	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	985					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CCTGGGCCCCCCAAAGGGCGC	0.662													3	7					0	0	0	0	T	32257825	T	T	32257825	3	4	130	1	0	0	0	0	1	0	0	0	15144	623	22	4	705	4	SPOCD1	1	32257825	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	5067725	32257825	216992796	6	23238											
KPNA6	23633	broad.mit.edu	37	chr1	32622524	32622524	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgatagtcttctcatggactCttatgtgagctctaccactg	8	14	8	11	1	4	1	1	1	4	0	5	3	4	2	1	1	2	1	1	1	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:32622524C>G	uc001bug.2	+	3	297	c.209C>G	c.(208-210)TCT>TGT	p.S70C	KPNA6_uc001buh.2_5'UTR|KPNA6_uc010ogx.1_Missense_Mutation_p.S67C|KPNA6_uc010ogy.1_Missense_Mutation_p.S75C|KPNA6_uc009vtz.2_Missense_Mutation_p.S9C	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	70					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CTCATGGACTCTTATGTGAGC	0.458													5	78					0	0	0	0	G	32622524	G	G	32622524	3	3	130	1	0	0	0	0	1	0	0	0	8473	913	32	2	219	2	KPNA6	1	32622524	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	364699	32622524	216628097	7	23239											
DCDC2B	149069	broad.mit.edu	37	chr1	32678154	32678154	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtaactggccattactaTgtggctgtcggagaggatga	9	11	14	7	1	0	2	0	1	0	1	1	4	0	3	1	5	2	2	1	5	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:32678154T>C	uc001bun.2	+	5	591	c.591T>C	c.(589-591)TAT>TAC	p.Y197Y		NM_001099434	NP_001092904	A2VCK2	DCD2B_HUMAN	doublecortin domain containing 2B	197	Doublecortin 2.				intracellular signal transduction						0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GCCATTACTATGTGGCTGTCG	0.592													7	46					0	0	0	0	C	32678154	C	C	32678154	2	2	130	1	0	0	0	0	0	0	0	1	4303	1471	51	5		5	DCDC2B	1	32678154	Silent	SNP	T	TCGA-CR-6484-01A-11D-1870-08	55630	32678154	216572467	8	23240											
DNAJB4	11080	broad.mit.edu	37	chr1	78470770	78470770	+	Translation_Start_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcttttacaaagggaaatCtaagttaatttcaaggcatt	14	16	6	5	0	3	0	1	0	2	0	3	1	3	1	0	2	1	2	0	2	6	7			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:78470770C>G	uc001dij.2	+	1	135	c.-24C>G	c.(-26--22)ATCTA>ATGTA		DNAJB4_uc010orn.1_Intron	NM_007034	NP_008965	Q9UDY4	DNJB4_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 4						protein folding|response to heat|response to unfolded protein	cytoplasm|plasma membrane	heat shock protein binding|unfolded protein binding				0						AAAGGGAAATCTAAGTTAATT	0.348													23	112					0	0	0	0	G	78470770	G	G	78470770	1	3	130	1	0	0	0	0	0	0	0	0	4644	928	32	2		2	DNAJB4	1	78470770	Translation_Start_Site	SNP	C	TCGA-CR-6484-01A-11D-1870-08	45792616	78470770	170779851	9	23241											
MCOLN3	55283	broad.mit.edu	37	chr1	85488044	85488044	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacacgagcatggtagaagTcccaagaagtatgctacaga	15	6	10	10	1	0	3	0	0	0	3	1	4	1	3	2	1	3	4	2	1	6	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:85488044T>C	uc001dkp.2	-	10	1228	c.1135A>G	c.(1135-1137)ACT>GCT	p.T379A	MCOLN3_uc001dko.2_5'UTR|MCOLN3_uc001dkq.2_Missense_Mutation_p.T323A	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	379	Helical; (Potential).					integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		ATGGTAGAAGTCCCAAGAAGT	0.368													5	29					0	0	0	0	C	85488044	C	C	85488044	3	2	130	1	0	0	0	0	1	0	0	0	9450	1667	58	5	542	5	MCOLN3	1	85488044	Missense_Mutation	SNP	T	TCGA-CR-6484-01A-11D-1870-08	7017274	85488044	163762577	10	23242											
COL11A1	1301	broad.mit.edu	37	chr1	103364318	103364318	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccaggaggaccttctgcAcctgcttccccctgttagaa	7	12	8	14	0	1	1	0	0	1	1	3	3	3	3	5	2	2	3	5	2	2	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:103364318A>G	uc001dul.2	-	56	4470	c.4152T>C	c.(4150-4152)GGT>GGC	p.G1384G	COL11A1_uc001duk.2_Silent_p.G580G|COL11A1_uc001dum.2_Silent_p.G1396G|COL11A1_uc001dun.2_Silent_p.G1345G|COL11A1_uc009weh.2_Silent_p.G1268G	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1384	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GACCTTCTGCACCTGCTTCCC	0.463													6	53					0	0	0	0	G	103364318	G	G	103364318	2	3	130	1	0	0	0	0	0	0	0	1	3682	146	6	5		5	COL11A1	1	103364318	Silent	SNP	A	TCGA-CR-6484-01A-11D-1870-08	17876274	103364318	145886303	11	23243											
NOTCH2	4853	broad.mit.edu	37	chr1	120462868	120462868	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacctgggccacggacattCacatctaacacatccacctc	11	8	6	16	1	2	1	1	1	1	0	4	2	3	2	4	2	1	0	4	2	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:120462868C>G	uc001eik.2	-	30	5719	c.5463G>C	c.(5461-5463)GTG>GTC	p.V1821V		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1821	Cytoplasmic (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACGGACATTCACATCTAACA	0.587			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				4	28					0	0	0	0	G	120462868	G	G	120462868	2	3	130	1	0	0	0	0	0	0	0	1	10602	813	29	2		2	NOTCH2	1	120462868	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	17098550	120462868	128787753	12	23244											
PSMD4	5710	broad.mit.edu	37	chr1	151234661	151234661	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gacaacagtgagtatatgcgGaatggagacttcttacccac	13	9	10	9	1	1	2	0	1	1	1	1	5	1	3	1	2	3	1	1	2	5	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:151234661G>A	uc001exl.2	+	2	113	c.51G>A	c.(49-51)CGG>CGA	p.R17R	PSMD4_uc001exn.2_Silent_p.R17R	NM_002810	NP_002801	P55036	PSMD4_HUMAN	proteasome 26S non-ATPase subunit 4	17	VWFA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGTATATGCGGAATGGAGACT	0.493													11	93					0	0	0	0	A	151234661	A	A	151234661	2	1	130	1	0	0	0	0	0	0	0	1	12762	1161	41	2		2	PSMD4	1	151234661	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	30771793	151234661	98015960	13	23245											
CELF3	11189	broad.mit.edu	37	chr1	151680372	151680372	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggagacctcgctccttctCagtgtcagcaaacttcacca	9	9	8	15	2	3	1	3	0	1	1	6	2	4	1	3	1	2	2	3	1	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:151680372C>G	uc001eys.1	-	6	1320	c.526G>C	c.(526-528)GAG>CAG	p.E176Q	CELF3_uc010pdh.1_5'UTR|CELF3_uc001eyr.2_Missense_Mutation_p.E175Q|CELF3_uc009wmy.2_Missense_Mutation_p.E176Q|CELF3_uc009wmx.1_Missense_Mutation_p.E176Q|CELF3_uc001eyt.2_Missense_Mutation_p.E99Q|C1orf230_uc001eyu.2_5'Flank	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4	176					nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2						CGCTCCTTCTCAGTGTCAGCA	0.642													4	27					0	0	0	0	G	151680372	G	G	151680372	3	3	130	1	0	0	0	0	1	0	0	0	3232	835	29	2	899	2	CELF3	1	151680372	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	445711	151680372	97570249	14	23246											
KIAA0907	22889	broad.mit.edu	37	chr1	155893435	155893435	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactgtttgcaaaagattctCacaaagcttcttggcagcag	12	11	8	10	0	2	1	1	0	2	1	3	1	2	1	0	1	3	5	0	1	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:155893435C>T	uc001fmi.1	-	8	961	c.937G>A	c.(937-939)GAG>AAG	p.E313K	KIAA0907_uc001fmj.1_Missense_Mutation_p.E313K|KIAA0907_uc009wrk.1_Missense_Mutation_p.E170K|KIAA0907_uc009wrl.1_RNA|KIAA0907_uc001fml.1_Missense_Mutation_p.E313K	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	313											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			AAAAGATTCTCACAAAGCTTC	0.383													13	56					0	0	0	0	T	155893435	T	T	155893435	3	4	130	1	0	0	0	0	1	0	0	0	8238	835	29	2	935	2	KIAA0907	1	155893435	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	4213063	155893435	93357186	15	23247											
SMG5	23381	broad.mit.edu	37	chr1	156238112	156238112	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagacagtttccgagtctCacacttcttcagttggtggt	8	13	11	9	1	3	1	2	0	2	1	5	3	4	1	1	3	0	2	1	3	0	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:156238112C>T	uc001foc.3	-	8	957	c.808G>A	c.(808-810)GAG>AAG	p.E270K		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	270					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					TTCCGAGTCTCACACTTCTTC	0.532													38	267					0	0	0	0	T	156238112	T	T	156238112	3	4	130	1	0	0	0	0	1	0	0	0	14860	835	29	2	2302	2	SMG5	1	156238112	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	344677	156238112	93012509	16	23248											
BCAN	63827	broad.mit.edu	37	chr1	156618362	156618362	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctcttctccacccaggaGaactgttcctgggtgaccct	6	12	8	15	0	2	2	0	1	2	1	5	3	3	2	4	2	1	1	4	2	1	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:156618362G>C	uc001fpp.2	+	6	1108	c.772G>C	c.(772-774)GAA>CAA	p.E258Q	BCAN_uc001fpo.2_Missense_Mutation_p.E258Q	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	258	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ccacCCAGGAGAACTGTTCCT	0.323													11	80					0	0	0	0	C	156618362	C	C	156618362	3	2	130	1	0	0	0	0	1	0	0	0	1347	943	33	2	790	2	BCAN	1	156618362	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	380250	156618362	92632259	17	23249											
NES	10763	broad.mit.edu	37	chr1	156641455	156641455	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggtgcttgagtttctggaGatttcagtgtttccaggttc	5	17	13	6	0	2	2	1	1	1	1	4	3	3	2	1	3	1	4	1	3	0	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:156641455G>C	uc001fpq.2	-	4	2658	c.2525C>G	c.(2524-2526)TCT>TGT	p.S842C		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	842	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGTTTCTGGAGATTTCAGTGT	0.433													12	126					0	0	0	0	C	156641455	C	C	156641455	3	2	130	1	0	0	0	0	1	0	0	0	10391	942	33	2	2344	2	NES	1	156641455	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	23093	156641455	92609166	18	23250											
IFI16	3428	broad.mit.edu	37	chr1	159019357	159019357	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cccacactcctcagatgcctCcatcaacaccaagcagcagt	12	6	5	18	0	2	1	2	0	0	1	4	1	4	1	5	0	4	2	5	0	2	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:159019357C>G	uc001ftg.2	+	8	1755	c.1465C>G	c.(1465-1467)CCA>GCA	p.P489A	IFI16_uc010pis.1_Missense_Mutation_p.P489A|IFI16_uc001fth.2_Intron|IFI16_uc010pit.1_Intron	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	489					cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					TCAGATGCCTCCATCAACACC	0.493													13	159					0	0	0	0	G	159019357	G	G	159019357	3	3	130	1	0	0	0	0	1	0	0	0	7550	855	30	2	1491	2	IFI16	1	159019357	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	2377902	159019357	90231264	19	23251											
USF1	7391	broad.mit.edu	37	chr1	161011934	161011934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggattgagtggcagggtagCcactgatggcgccagttccc	7	9	15	10	1	0	2	0	2	0	0	1	3	1	3	3	4	1	3	3	4	1	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:161011934C>T	uc001fxi.2	-	5	443	c.248G>A	c.(247-249)GGC>GAC	p.G83D	USF1_uc001fxj.2_Missense_Mutation_p.G24D	NM_007122	NP_009053	P22415	USF1_HUMAN	upstream stimulatory factor 1 isoform 1	83					cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GGCAGGGTAGCCACTGATGGC	0.547													7	54					0	0	0	0	T	161011934	T	T	161011934	3	4	130	1	0	0	0	0	1	0	0	0	17100	739	26	4	712	4	USF1	1	161011934	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1992577	161011934	88238687	20	23252											
PFDN2	5202	broad.mit.edu	37	chr1	161070553	161070553	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctgctggcttctcatcttCtcccatgagacgaatgttgt	6	14	10	11	1	3	1	1	1	3	1	5	3	3	1	1	2	1	4	1	2	1	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:161070553C>T	uc001fxu.2	-	4	435	c.385G>A	c.(385-387)GAA>AAA	p.E129K		NM_012394	NP_036526	Q9UHV9	PFD2_HUMAN	prefoldin subunit 2	129					'de novo' posttranslational protein folding	prefoldin complex	unfolded protein binding				0	all_cancers(52;1.84e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TTCTCATCTTCTCCCATGAGA	0.493													11	94					0	0	0	0	T	161070553	T	T	161070553	3	4	130	1	0	0	0	0	1	0	0	0	11811	922	32	2	83	2	PFDN2	1	161070553	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	58619	161070553	88180068	21	23253											
FCGR2C	9103	broad.mit.edu	37	chr1	161569462	161569462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatcagaaagagacaacctGaagaaaccaacaatgactat	20	5	6	10	0	1	5	1	2	0	3	1	6	1	5	3	0	3	0	3	0	7	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:161569462G>A	uc001gav.2	+	8	940	c.841G>A	c.(841-843)GAA>AAA	p.E281K		NM_201563	NP_963857			Fc fragment of IgG, low affinity IIc, receptor												0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			gagacaacctgaagaaaccaa	0.199													5	68					0	0	0	0	A	161569462	A	A	161569462	3	1	130	1	0	0	0	0	1	0	0	0	5815	1291	45	2	867	2	FCGR2C	1	161569462	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	498909	161569462	87681159	22	23254											
DDR2	4921	broad.mit.edu	37	chr1	162741855	162741855	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtccagcccagtggccctGagggggtgccccactatgca	7	6	13	15	0	0	1	0	1	0	0	1	1	1	1	5	3	3	1	5	3	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:162741855G>C	uc001gcf.2	+	14	2011	c.1546G>C	c.(1546-1548)GAG>CAG	p.E516Q	DDR2_uc001gcg.2_Missense_Mutation_p.E516Q	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	516	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			CAGTGGCCCTGAGGGGGTGCC	0.587													3	33					0	0	0	0	C	162741855	C	C	162741855	3	2	130	1	0	0	0	0	1	0	0	0	4354	1291	45	2	1588	2	DDR2	1	162741855	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1172393	162741855	86508766	23	23255											
UCK2	7371	broad.mit.edu	37	chr1	165872469	165872469	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcttgagcagattttatctCagtacattacgttcgtcaag	11	15	7	8	2	3	2	2	1	2	1	5	2	3	2	0	0	3	3	0	0	4	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:165872469C>G	uc001gdp.2	+	5	731	c.550C>G	c.(550-552)CAG>GAG	p.Q184E	UCK2_uc010plb.1_Missense_Mutation_p.Q46E	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	184		Substrate.			pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					GATTTTATCTCAGTACATTAC	0.408													7	124					0	0	0	0	G	165872469	G	G	165872469	3	3	130	1	0	0	0	0	1	0	0	0	16992	827	29	2	568	2	UCK2	1	165872469	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	3130614	165872469	83378152	24	23256											
FMO2	2327	broad.mit.edu	37	chr1	171154965	171154965	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgagagaactgaagatattgGaggagtgtggaggttcaaag	14	9	16	2	0	1	4	1	2	0	2	1	8	1	7	0	4	1	1	0	4	4	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:171154965G>A	uc001ghk.1	+	2	230	c.113G>A	c.(112-114)GGA>GAA	p.G38E	FMO2_uc010pmd.1_Intron	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	38					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GAAGATATTGGAGGAGTGTGG	0.453													14	134					0	0	0	0	A	171154965	A	A	171154965	3	1	130	1	0	0	0	0	1	0	0	0	5987	1174	41	2	115	2	FMO2	1	171154965	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	5282496	171154965	78095656	25	23257											
RC3H1	149041	broad.mit.edu	37	chr1	173951999	173951999	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacaaagcagaaccatcttCtaaggccagcagaaccaact	16	6	7	12	0	2	3	0	1	2	2	2	3	2	3	3	1	5	2	3	1	5	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:173951999C>G	uc001gju.3	-	4	721	c.634G>C	c.(634-636)GAA>CAA	p.E212Q	RC3H1_uc010pms.1_Missense_Mutation_p.E212Q|RC3H1_uc001gjv.2_Missense_Mutation_p.E212Q|RC3H1_uc010pmt.1_Missense_Mutation_p.E212Q	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	212					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GAACCATCTTCTAAGGCCAGC	0.403													10	131					0	0	0	0	G	173951999	G	G	173951999	3	3	130	1	0	0	0	0	1	0	0	0	13231	922	32	2	2831	2	RC3H1	1	173951999	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	2797034	173951999	75298622	26	23258											
LAMC2	3918	broad.mit.edu	37	chr1	183209189	183209189	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcaggagattgggagtctGaacttggaagccaatgtgac	11	10	13	7	0	2	3	1	2	2	1	3	6	2	5	1	3	2	0	1	3	3	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:183209189G>A	uc001gqa.2	+	21	3398	c.3084G>A	c.(3082-3084)CTG>CTA	p.L1028L	LAMC2_uc001gpz.3_Silent_p.L1028L|LAMC2_uc010poa.1_Silent_p.L728L	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	1028	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						TTGGGAGTCTGAACTTGGAAG	0.493													17	122					0	0	0	0	A	183209189	A	A	183209189	2	1	130	1	0	0	0	0	0	0	0	1	8655	1277	45	2		2	LAMC2	1	183209189	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	9257190	183209189	66041432	27	23259											
HMCN1	83872	broad.mit.edu	37	chr1	186086731	186086731	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taagactgcttcccaggggaGatggctatagaattctgtcc	10	11	11	9	0	1	3	0	0	1	3	3	4	3	3	2	3	1	2	2	3	4	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:186086731G>C	uc001grq.1	+	77	12053	c.11824G>C	c.(11824-11826)GAT>CAT	p.D3942H		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3942	Ig-like C2-type 38.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TCCCAGGGGAGATGGCTATAG	0.423													7	86					0	0	0	0	C	186086731	C	C	186086731	3	2	130	1	0	0	0	0	1	0	0	0	7259	942	33	2	12130	2	HMCN1	1	186086731	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2877542	186086731	63163890	28	23260											
KIF14	9928	broad.mit.edu	37	chr1	200522745	200522745	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggagagacttagctagaGattctagttcctggtggaca	12	10	13	6	0	1	3	0	0	1	3	2	7	2	5	1	3	1	2	1	3	3	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:200522745G>C	uc010ppk.1	-	30	5157	c.4718C>G	c.(4717-4719)TCT>TGT	p.S1573C	KIF14_uc010ppj.1_Missense_Mutation_p.S1082C	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1573	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						CTTAGCTAGAGATTCTAGTTC	0.398													9	48					0	0	0	0	C	200522745	C	C	200522745	3	2	130	1	0	0	0	0	1	0	0	0	8315	942	33	2	232	2	KIF14	1	200522745	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	14436014	200522745	48727876	29	23261											
CSRP1	1465	broad.mit.edu	37	chr1	201465408	201465408	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctgacacaccccacatttCttgcctcctccccagttcgg	6	12	5	18	1	2	1	0	1	2	0	5	1	4	1	6	1	1	1	6	1	0	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:201465408C>G	uc001gws.2	-	2	215	c.24G>C	c.(22-24)AAG>AAC	p.K8N	CSRP1_uc010ppr.1_Missense_Mutation_p.K8N|CSRP1_uc010pps.1_Missense_Mutation_p.K8N	NM_004078	NP_004069	P21291	CSRP1_HUMAN	cysteine and glycine-rich protein 1 isoform 1	8						nucleus	zinc ion binding			ovary(1)	1						CCCCACATTTCTTGCCTCCTC	0.483													20	116					0	0	0	0	G	201465408	G	G	201465408	3	3	130	1	0	0	0	0	1	0	0	0	3983	912	32	2	593	2	CSRP1	1	201465408	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	942663	201465408	47785213	30	23262											
ATP2B4	493	broad.mit.edu	37	chr1	203708719	203708719	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttccctccacgaaagcattCagaaaccctacaaccaaaag	16	6	5	14	1	1	1	1	0	0	1	3	2	3	1	4	0	4	2	4	0	6	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:203708719C>G	uc001gzw.2	+	21	4239	c.3355C>G	c.(3355-3357)CAG>GAG	p.Q1119E	ATP2B4_uc001gzv.2_3'UTR|ATP2B4_uc001gzx.2_Missense_Mutation_p.Q186E|ATP2B4_uc009xar.2_3'UTR	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1155	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CGAAAGCATTCAGAAACCCTA	0.488													16	101					0	0	0	0	G	203708719	G	G	203708719	3	3	130	1	0	0	0	0	1	0	0	0	1144	827	29	2	3615	2	ATP2B4	1	203708719	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	2243311	203708719	45541902	31	23263											
RPS6KC1	26750	broad.mit.edu	37	chr1	213414696	213414696	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaattgtatagtctaaaatCagaacctttgaaaccattct	17	13	4	7	0	3	2	1	1	2	1	3	2	3	2	2	0	2	1	2	0	8	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:213414696C>A	uc010ptr.1	+	11	2036	c.1877C>A	c.(1876-1878)TCA>TAA	p.S626*	RPS6KC1_uc001hkd.2_Nonsense_Mutation_p.S614*|RPS6KC1_uc010pts.1_Nonsense_Mutation_p.S414*|RPS6KC1_uc010ptt.1_Nonsense_Mutation_p.S414*|RPS6KC1_uc010ptu.1_Nonsense_Mutation_p.S445*|RPS6KC1_uc010ptv.1_Nonsense_Mutation_p.S161*|RPS6KC1_uc001hke.2_Nonsense_Mutation_p.S445*	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	626					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		AGTCTAAAATCAGAACCTTTG	0.388													4	42					2.56e-06	2.75072e-06	1	0	A	213414696	A	A	213414696	4	1	130	1	0	0	0	0	0	1	0	0	13723	838	29	2	1919	2	RPS6KC1	1	213414696	Nonsense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	9705977	213414696	35835925	32	23264											
MIA3	375056	broad.mit.edu	37	chr1	222803432	222803432	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgctacaagaaatgtcatCaaaactgaagtcagcgcagc	15	8	8	10	1	3	2	3	1	0	1	3	2	3	2	0	0	5	2	0	0	6	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:222803432C>T	uc001hnl.2	+	4	2879	c.2870C>T	c.(2869-2871)TCA>TTA	p.S957L	MIA3_uc009xea.1_Missense_Mutation_p.S793L	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	957	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		GAAATGTCATCAAAACTGAAG	0.428													8	58					0	0	0	0	T	222803432	T	T	222803432	3	4	130	1	0	0	0	0	1	0	0	0	9618	838	29	2	2884	2	MIA3	1	222803432	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	9388736	222803432	26447189	33	23265											
ZP4	57829	broad.mit.edu	37	chr1	238045807	238045807	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccaaggattaaggtcccaGaaaggcctgccacccacaga	13	5	9	14	0	0	2	0	0	0	2	2	3	2	3	5	3	1	0	5	3	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:238045807G>C	uc001hym.2	-	12	1538	c.1538C>G	c.(1537-1539)TCT>TGT	p.S513C	LOC100130331_uc010pyc.1_RNA	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	513	Helical; (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TAAGGTCCCAGAAAGGCCTGC	0.453													15	75					0	0	0	0	C	238045807	C	C	238045807	3	2	130	1	0	0	0	0	1	0	0	0	18285	942	33	2	88	2	ZP4	1	238045807	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	15242375	238045807	11204814	34	23266											
OR2T12	127064	broad.mit.edu	37	chr1	248458752	248458752	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagtgaatcaggagaatCatgagggcattgctaaacag	14	8	11	8	0	2	3	2	2	0	1	3	4	3	3	1	2	2	2	1	2	4	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:248458752C>A	uc010pzj.1	-	1	129	c.129G>T	c.(127-129)ATG>ATT	p.M43I		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TCAGGAGAATCATGAGGGCAT	0.522													21	83					4.16121e-05	4.39565e-05	1	0	A	248458752	A	A	248458752	3	1	130	1	0	0	0	0	1	0	0	0	11073	826	29	2	836	2	OR2T12	1	248458752	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	10412945	248458752	791869	35	23267											
OR2M7	391196	broad.mit.edu	37	chr1	248486993	248486993	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctctggtcacttccttgttgCggaggctataaatgagagga	9	12	12	8	1	2	1	1	1	1	1	3	4	3	3	1	4	1	2	1	4	3	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr1:248486993C>T	uc010pzk.1	-	1	878	c.878G>A	c.(877-879)CGC>CAC	p.R293H		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCCTTGTTGCGGAGGCTATA	0.428													16	43					0	0	0	0	T	248486993	T	T	248486993	3	4	130	1	0	0	0	0	1	0	0	0	11068	768	27	1	63	1	OR2M7	1	248486993	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	28241	248486993	763628	36	23268											
PDIA6	10130	broad.mit.edu	37	chr2	10931955	10931955	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaccaaggagcatagaactCaaccatccaaacatcttcac	17	6	4	14	0	3	1	2	0	1	1	4	2	4	2	3	1	4	1	3	1	5	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:10931955C>G	uc002rau.2	-	6	688	c.550G>C	c.(550-552)GAG>CAG	p.E184Q	PDIA6_uc010yjg.1_Missense_Mutation_p.E181Q|PDIA6_uc002rav.2_Missense_Mutation_p.E236Q|PDIA6_uc010yjh.1_Missense_Mutation_p.E189Q|PDIA6_uc002raw.2_Missense_Mutation_p.E232Q	NM_005742	NP_005733	Q15084	PDIA6_HUMAN	protein disulfide isomerase A6 precursor	184	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding	endoplasmic reticulum lumen|ER-Golgi intermediate compartment|melanosome|plasma membrane	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.149)|OV - Ovarian serous cystadenocarcinoma(76;0.15)		GCATAGAACTCAACCATCCAA	0.398													8	45					0	0	0	0	G	10931955	G	G	10931955	3	3	130	1	0	0	0	0	1	0	0	0	11726	835	29	2	804	2	PDIA6	2	10931955	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08		10931955	232267418	37	23269											
ROCK2	9475	broad.mit.edu	37	chr2	11364578	11364578	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagtgaatccgcataaaatgGagtatcccctaaaatttcaa	17	10	6	8	1	1	1	1	1	0	0	3	2	3	2	3	1	0	2	3	1	8	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:11364578G>T	uc002rbd.1	-	7	1326	c.877C>A	c.(877-879)CCA>ACA	p.P293T		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	293	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		GCATAAAATGGAGTATCCCCT	0.318													11	98					3.07112e-06	3.28111e-06	1	0	T	11364578	T	T	11364578	3	4	130	1	0	0	0	0	1	0	0	0	13583	1174	41	2	3397	2	ROCK2	2	11364578	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	432623	11364578	231834795	38	23270											
ZNF513	130557	broad.mit.edu	37	chr2	27600989	27600989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cactggggccctggggccccCcactggcaccccctccagcc	4	4	11	22	0	0	0	0	0	0	0	1	0	1	0	8	5	1	1	8	5	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:27600989C>T	uc002rkk.2	-	4	1249	c.1049G>A	c.(1048-1050)GGG>GAG	p.G350E	ZNF513_uc002rkj.2_Missense_Mutation_p.G288E	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	350					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGGGCCCCCCACTGGCACC	0.652													10	69					0	0	0	0	T	27600989	T	T	27600989	3	4	130	1	0	0	0	0	1	0	0	0	18025	623	22	4	580	4	ZNF513	2	27600989	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	16236411	27600989	215598384	39	23271											
IFT172	26160	broad.mit.edu	37	chr2	27695135	27695135	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacgaagtttccggtccctGaagaggagcttgtgtccagt	9	10	12	10	2	0	2	0	1	0	1	3	4	3	3	3	2	1	2	3	2	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:27695135G>A	uc002rku.2	-	15	1557	c.1506C>T	c.(1504-1506)TTC>TTT	p.F502F	IFT172_uc002rkw.2_Silent_p.F502F|IFT172_uc010yls.1_Silent_p.F481F|IFT172_uc010ezc.2_Silent_p.F502F|IFT172_uc002rkv.2_Silent_p.F476F	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	502	WD 8.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TCCGGTCCCTGAAGAGGAGCT	0.547													14	148					0	0	0	0	A	27695135	A	A	27695135	2	1	130	1	0	0	0	0	0	0	0	1	7596	1281	45	2		2	IFT172	2	27695135	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	94146	27695135	215504238	40	23272											
GALNT14	79623	broad.mit.edu	37	chr2	31133797	31133797	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accatgtcccagtgctggctCatgagtgaggactcacatgg	9	9	12	11	0	2	2	2	2	0	0	3	3	3	3	2	3	1	2	2	3	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:31133797C>T	uc002rnr.2	-	15	2248	c.1629G>A	c.(1627-1629)ATG>ATA	p.M543I	GALNT14_uc002rnq.2_Missense_Mutation_p.M523I|GALNT14_uc002rns.2_Missense_Mutation_p.M548I|GALNT14_uc010ymr.1_Missense_Mutation_p.M508I	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	543	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					AGTGCTGGCTCATGAGTGAGG	0.567													8	67					0	0	0	0	T	31133797	T	T	31133797	3	4	130	1	0	0	0	0	1	0	0	0	6247	826	29	2	33	2	GALNT14	2	31133797	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	3438662	31133797	212065576	41	23273											
SPAST	6683	broad.mit.edu	37	chr2	32289083	32289083	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacccgctgtttgtaggcttCgcgctgctgcgtttggtcgc	2	14	13	12	5	0	0	0	0	0	0	2	0	0	0	1	2	3	7	1	2	2	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:32289083C>T	uc002roc.2	+	1	404	c.183C>T	c.(181-183)TTC>TTT	p.F61F	SPAST_uc002rod.2_Silent_p.F61F	NM_014946	NP_055761	Q9UBP0	SPAST_HUMAN	spastin isoform 1	61	Required for interaction with SSNA1 and microtubules.|Required for interaction with RTN1.|Nuclear export signal.|Required for interaction with ATL1.|Helical; (Potential).|Required for midbody localization.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTGTAGGCTTCGCGCTGCTGC	0.502													4	46					0	0	0	0	T	32289083	T	T	32289083	2	4	130	1	0	0	0	0	0	0	0	1	15063	883	31	1		1	SPAST	2	32289083	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1155286	32289083	210910290	42	23274											
ATL2	64225	broad.mit.edu	37	chr2	38537571	38537571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttacattctgaagctcttCatgttgattttgttttacct	7	20	5	9	0	3	2	1	2	2	0	3	2	3	2	2	0	3	3	2	0	3	8			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:38537571C>T	uc002rqq.2	-	8	853	c.823G>A	c.(823-825)GAA>AAA	p.E275K	ATL2_uc010ynm.1_Missense_Mutation_p.E257K|ATL2_uc010ynn.1_Missense_Mutation_p.E257K|ATL2_uc010yno.1_Missense_Mutation_p.E104K|ATL2_uc002rqs.2_Missense_Mutation_p.E275K|ATL2_uc002rqr.2_Missense_Mutation_p.E104K	NM_001135673	NP_001129145	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2 isoform 2	275	Potential.|Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			ovary(1)|kidney(1)|skin(1)	3						TGAAGCTCTTCATGTTGATTT	0.378													10	57					0	0	0	0	T	38537571	T	T	38537571	3	4	130	1	0	0	0	0	1	0	0	0	1109	835	29	2	1064	2	ATL2	2	38537571	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	6248488	38537571	204661802	43	23275											
PLEKHH2	130271	broad.mit.edu	37	chr2	43986079	43986079	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccagatggatggccctcCggggacacagtgctgctgac	9	6	13	13	1	0	2	0	1	0	1	1	4	1	4	3	4	3	2	3	4	1	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:43986079C>T	uc010yny.1	+	27	4065	c.3982C>T	c.(3982-3984)CGG>TGG	p.R1328W		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1328	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GATGGCCCTCCGGGGACACAG	0.373													3	29					0	0	0	0	T	43986079	T	T	43986079	3	4	130	1	0	0	0	0	1	0	0	0	12132	643	23	1	4084	1	PLEKHH2	2	43986079	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	5448508	43986079	199213294	44	23276											
MDH1	4190	broad.mit.edu	37	chr2	63831977	63831977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttatgaagctctgaaagatGacagctggctcaagggagaa	14	9	12	6	0	2	5	1	3	1	2	2	6	2	5	0	2	2	3	0	2	5	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:63831977G>A	uc002scj.1	+	6	702	c.646G>A	c.(646-648)GAC>AAC	p.D216N	MDH1_uc010ypv.1_Missense_Mutation_p.D234N|MDH1_uc010ypw.1_Missense_Mutation_p.D121N	NM_005917	NP_005908	P40925	MDHC_HUMAN	cytosolic malate dehydrogenase	216					gluconeogenesis|tricarboxylic acid cycle	centrosome|cytosol	L-malate dehydrogenase activity|malic enzyme activity			kidney(2)	2					NADH(DB00157)	TCTGAAAGATGACAGCTGGCT	0.433													8	46					0	0	0	0	A	63831977	A	A	63831977	3	1	130	1	0	0	0	0	1	0	0	0	9461	1290	45	2	668	2	MDH1	2	63831977	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	19845898	63831977	179367396	45	23277											
ATP6V1B1	525	broad.mit.edu	37	chr2	71189955	71189955	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcgctgaccactgctgaattCcttgcctaccagtgtgagaa	9	10	10	12	1	0	3	0	3	0	1	1	4	1	3	4	0	3	2	4	0	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:71189955C>T	uc002shj.2	+	9	921	c.834C>T	c.(832-834)TTC>TTT	p.F278F	ATP6V1B1_uc010fdv.2_Silent_p.F278F|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Silent_p.F236F	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	278					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						CTGCTGAATTCCTTGCCTACC	0.582													11	69					0	0	0	0	T	71189955	T	T	71189955	2	4	130	1	0	0	0	0	0	0	0	1	1180	854	30	2		2	ATP6V1B1	2	71189955	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	7357978	71189955	172009418	46	23278											
TBC1D8	11138	broad.mit.edu	37	chr2	101655014	101655014	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgcctccaccaggctgtctCggtcccggagctcaatgaac	7	7	11	16	3	2	1	1	1	1	0	5	2	4	2	4	3	2	2	4	3	2	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:101655014C>T	uc010fiv.2	-	7	1270	c.1139G>A	c.(1138-1140)CGA>CAA	p.R380Q	TBC1D8_uc010yvw.1_Missense_Mutation_p.R395Q|TBC1D8_uc002tau.3_Missense_Mutation_p.R137Q	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	380					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CAGGCTGTCTCGGTCCCGGAG	0.587													20	135					0	0	0	0	T	101655014	T	T	101655014	3	4	130	1	0	0	0	0	1	0	0	0	15691	884	31	1	2339	1	TBC1D8	2	101655014	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	30465059	101655014	141544359	47	23279											
C2orf29	55571	broad.mit.edu	37	chr2	101874329	101874329	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcacccccacgggaactcttCaaaaagacgcctcgccagat	12	5	8	16	3	2	2	1	0	1	2	3	3	2	3	4	1	1	1	4	1	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:101874329C>G	uc002taw.3	+	2	673	c.591C>G	c.(589-591)TTC>TTG	p.F197L		NM_017546	NP_060016	Q9UKZ1	CB029_HUMAN	hypothetical protein LOC55571	197					cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol				ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GGGAACTCTTCAAAAAGACGC	0.473													11	92					0	0	0	0	G	101874329	G	G	101874329	3	3	130	1	0	0	0	0	1	0	0	0	2171	825	29	2	597	2	C2orf29	2	101874329	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	219315	101874329	141325044	48	23280											
SLC5A7	60482	broad.mit.edu	37	chr2	108626898	108626898	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtggcaggttatgtttctGgcctcttcctgagaataact	7	14	10	10	1	2	1	0	1	2	1	3	2	3	1	3	3	1	3	3	3	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:108626898G>T	uc002tdv.2	+	9	1600	c.1324G>T	c.(1324-1326)GGC>TGC	p.G442C	SLC5A7_uc010ywm.1_Missense_Mutation_p.G195C|SLC5A7_uc010fjj.2_Missense_Mutation_p.G442C|SLC5A7_uc010ywn.1_Missense_Mutation_p.G329C	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	442	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TTATGTTTCTGGCCTCTTCCT	0.453													8	67					0.00307968	0.00317275	1	0	T	108626898	T	T	108626898	3	4	130	1	0	0	0	0	1	0	0	0	14734	1348	47	4	1354	4	SLC5A7	2	108626898	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6752569	108626898	134572475	49	23281											
ZC3H8	84524	broad.mit.edu	37	chr2	112994207	112994207	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccagggccaggccattttcGcttcattttcttctgtttgc	4	17	8	12	1	3	0	1	0	2	0	5	0	4	0	3	2	1	2	3	2	0	7			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:112994207G>A	uc002thp.2	-	4	542	c.436C>T	c.(436-438)CGA>TGA	p.R146*		NM_032494	NP_115883	Q8N5P1	ZC3H8_HUMAN	zinc finger CCCH-type containing 8	146					apoptosis|negative regulation of T cell differentiation in thymus|negative regulation of transcription, DNA-dependent|positive regulation of thymocyte apoptosis|response to antibiotic|T cell homeostasis	nucleus	RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGCCATTTTCGCTTCATTTTC	0.353													11	66					0	0	0	0	A	112994207	A	A	112994207	4	1	130	1	0	0	0	0	0	1	0	0	17641	1095	38	1	459	1	ZC3H8	2	112994207	Nonsense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	4367309	112994207	130205166	50	23282											
PSD4	23550	broad.mit.edu	37	chr2	113950670	113950670	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaggagtacctgtccttcttCcagtttggaggccagagtct	7	12	12	10	0	2	1	0	0	2	1	4	4	4	3	4	3	1	2	4	3	1	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:113950670C>G	uc002tjc.2	+	7	2067	c.1884C>G	c.(1882-1884)TTC>TTG	p.F628L	PSD4_uc002tjd.2_Missense_Mutation_p.F249L|PSD4_uc002tje.2_Missense_Mutation_p.F599L|PSD4_uc002tjf.2_Missense_Mutation_p.F249L	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	628	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TGTCCTTCTTCCAGTTTGGAG	0.622													4	68					0	0	0	0	G	113950670	G	G	113950670	3	3	130	1	0	0	0	0	1	0	0	0	12711	854	30	2	1906	2	PSD4	2	113950670	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	956463	113950670	129248703	51	23283											
R3HDM1	23518	broad.mit.edu	37	chr2	136389447	136389447	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctaggtctccacgtaaaaaaTtccccccaatgacatcttac	13	10	4	14	1	2	1	0	1	2	0	4	1	3	1	4	1	1	1	4	1	6	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:136389447T>A	uc002tuo.2	+	9	944	c.574T>A	c.(574-576)TTC>ATC	p.F192I	R3HDM1_uc010fni.2_Missense_Mutation_p.F190I|R3HDM1_uc002tup.2_Missense_Mutation_p.F136I|R3HDM1_uc010zbh.1_Missense_Mutation_p.F24I	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	192	R3H.						nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		ACGTAAAAAATTCCCCCCAAT	0.398													21	98					0	0	0	0	A	136389447	A	A	136389447	3	1	130	1	0	0	0	0	1	0	0	0	12952	1493	52	5	600	5	R3HDM1	2	136389447	Missense_Mutation	SNP	T	TCGA-CR-6484-01A-11D-1870-08	22438777	136389447	106809926	52	23284											
BAZ2B	29994	broad.mit.edu	37	chr2	160194206	160194207	+	Missense_Mutation	DNP	GC	AA	AA																															aattctccatcatgctccttGcacaatttagtaaatgattt																										TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:160194206_160194207GC>AA	uc002uao.2	-	32	5883_5884	c.5531_5532GC>TT	c.(5530-5532)TGC>TTT	p.C1844F	BAZ2B_uc002uap.2_Missense_Mutation_p.C1808F	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1844					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CATGCTCCTTGCACAATTTAGT	0.426													14	80					0	0	0	0	AA	160194207	AA	AA	160194206	3	1	130	1	0	0	0	0	1	0	0	0	1334	1311	46	4	998	4	BAZ2B	2	160194206	Missense_Mutation	DNP	GC	TCGA-CR-6484-01A-11D-1870-08	23804759	160194206	83005167	53	23285											
IFIH1	64135	broad.mit.edu	37	chr2	163163360	163163360	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaacttgtgataaattctCaatctctgtgaataacagta	15	14	5	7	0	3	2	2	2	2	0	5	2	3	2	0	0	2	1	0	0	7	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:163163360C>G	uc002uce.2	-	3	850	c.628G>C	c.(628-630)GAG>CAG	p.E210Q		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	210					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						GATAAATTCTCAATCTCTGTG	0.368													3	38					0	0	0	0	G	163163360	G	G	163163360	3	3	130	1	0	0	0	0	1	0	0	0	7559	835	29	2	2505	2	IFIH1	2	163163360	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	2969154	163163360	80036013	54	23286											
TTN	7273	broad.mit.edu	37	chr2	179417226	179417226	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgtgccccagggatatctGacaggtcaacttcaggtgta	9	11	11	10	0	3	1	2	1	1	0	3	2	3	2	2	3	2	1	2	3	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:179417226G>C	uc010zfg.1	-	284	82921	c.82697C>G	c.(82696-82698)TCA>TGA	p.S27566*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.S21261*|TTN_uc010zfi.1_Nonsense_Mutation_p.S21194*|TTN_uc010zfj.1_Nonsense_Mutation_p.S21069*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28493							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGGATATCTGACAGGTCAAC	0.423													6	35					0	0	0	0	C	179417226	C	C	179417226	4	2	130	1	0	0	0	0	0	1	0	0	16803	1294	45	2	17690	2	TTN	2	179417226	Nonsense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	16253866	179417226	63782147	55	23287											
MYO1B	4430	broad.mit.edu	37	chr2	192225422	192225422	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaacttccatgtgttctatCagctgctctctggtgcctct	6	15	8	12	0	4	0	1	0	3	0	6	1	5	0	2	1	4	3	2	1	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:192225422C>T	uc010fsg.2	+	8	883	c.628C>T	c.(628-630)CAG>TAG	p.Q210*	MYO1B_uc002usq.2_Nonsense_Mutation_p.Q210*|MYO1B_uc002usr.2_Nonsense_Mutation_p.Q210*|MYO1B_uc002uss.1_Nonsense_Mutation_p.Q210*	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	210	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			TGTGTTCTATCAGCTGCTCTC	0.338													20	140					0	0	0	0	T	192225422	T	T	192225422	4	4	130	1	0	0	0	0	0	1	0	0	10122	827	29	2	654	2	MYO1B	2	192225422	Nonsense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	12808196	192225422	50973951	56	23288											
PAX3	5077	broad.mit.edu	37	chr2	223066840	223066840	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggttccagacccccggtgaGaggggagagcgcgtaatcag	10	5	16	10	3	1	3	1	1	0	3	2	5	2	3	3	4	1	2	3	4	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:223066840G>C	uc010fwo.2	-	8	1609	c.1243C>G	c.(1243-1245)CTC>GTC	p.L415V	PAX3_uc002vmt.1_Missense_Mutation_p.L415V|PAX3_uc002vmy.1_Missense_Mutation_p.L414V|PAX3_uc002vmv.1_Missense_Mutation_p.L415V|PAX3_uc002vmw.1_Intron|PAX3_uc002vmx.1_Intron	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	415					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCCCGGTGAGAGGGGAGAGC	0.547			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						5	21					0	0	0	0	C	223066840	C	C	223066840	3	2	130	1	0	0	0	0	1	0	0	0	11534	942	33	2	314	2	PAX3	2	223066840	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	30841418	223066840	20132533	57	23289											
WDFY1	57590	broad.mit.edu	37	chr2	224809972	224809972	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcagcaccgggcggctgctCtgcggcctggagtggatttc	5	8	16	12	3	1	0	0	0	1	0	2	2	1	2	2	5	4	4	2	5	0	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:224809972C>G	uc002vnq.2	-	1	81	c.30G>C	c.(28-30)CAG>CAC	p.Q10H		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	10						cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		GGCGGCTGCTCTGCGGCCTGG	0.726													4	27					0	0	0	0	G	224809972	G	G	224809972	3	3	130	1	0	0	0	0	1	0	0	0	17336	912	32	2	1250	2	WDFY1	2	224809972	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1743132	224809972	18389401	58	23290											
ARMC9	80210	broad.mit.edu	37	chr2	232146798	232146798	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgtatgtgaatggagctctGtacagcatcctttctgttcc	7	14	9	11	1	2	1	0	1	2	0	4	2	4	2	3	1	3	5	3	1	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr2:232146798G>A	uc002vrq.3	+	17	1690	c.1578G>A	c.(1576-1578)CTG>CTA	p.L526L	ARMC9_uc002vrp.3_Silent_p.L526L|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	526							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		ATGGAGCTCTGTACAGCATCC	0.428													16	143					0	0	0	0	A	232146798	A	A	232146798	2	1	130	1	0	0	0	0	0	0	0	1	960	1364	48	4		4	ARMC9	2	232146798	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	7336826	232146798	11052575	59	23291											
CNTN4	152330	broad.mit.edu	37	chr3	2908579	2908579	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgtggttaccaataccGtgacaaaccacaaggtcctg	11	9	9	12	1	0	1	0	1	0	0	1	1	1	1	5	2	3	1	5	2	5	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr3:2908579G>A	uc003bpc.2	+	7	819	c.598G>A	c.(598-600)GTG>ATG	p.V200M	CNTN4_uc003bpb.1_Translation_Start_Site|CNTN4_uc003bpd.1_Missense_Mutation_p.V200M	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	200	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TACCAATACCGTGACAAACCA	0.398													8	54					0	0	0	0	A	2908579	A	A	2908579	3	1	130	1	0	0	0	0	1	0	0	0	3658	1145	40	1	616	1	CNTN4	3	2908579	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08		2908579	195113851	60	23292											
WDR48	57599	broad.mit.edu	37	chr3	39104562	39104562	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcctatgttattcgagatGaagtggagaagtacaaccga	13	12	10	6	2	0	3	0	1	0	2	2	6	1	3	2	1	2	2	2	1	6	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr3:39104562G>C	uc003cit.2	+	2	80	c.70G>C	c.(70-72)GAA>CAA	p.E24Q	WDR48_uc011ayt.1_Missense_Mutation_p.E24Q|WDR48_uc011ayu.1_5'UTR|WDR48_uc011ayv.1_Intron|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	24					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TATTCGAGATGAAGTGGAGAA	0.388													9	74					0	0	0	0	C	39104562	C	C	39104562	3	2	130	1	0	0	0	0	1	0	0	0	17369	1291	45	2	76	2	WDR48	3	39104562	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	36195983	39104562	158917868	61	23293											
CCDC36	339834	broad.mit.edu	37	chr3	49293924	49293924	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagaatgatgatctccaaGaagaggctgcactgccagca	15	6	10	10	0	1	5	0	2	1	3	2	5	1	5	2	1	3	3	2	1	4	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr3:49293924G>C	uc003cwk.2	+	10	1381	c.994G>C	c.(994-996)GAA>CAA	p.E332Q	CCDC36_uc011bck.1_Missense_Mutation_p.E332Q	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	332										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		TGATCTCCAAGAAGAGGCTGC	0.512													19	82					0	0	0	0	C	49293924	C	C	49293924	3	2	130	1	0	0	0	0	1	0	0	0	2821	943	33	2	1020	2	CCDC36	3	49293924	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	10189362	49293924	148728506	62	23294											
QTRTD1	79691	broad.mit.edu	37	chr3	113798799	113798799	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaggtgctcgagtgtattGaaagaggagtggacttattt	11	13	14	3	1	0	3	0	2	0	1	1	6	0	5	0	3	1	2	0	3	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr3:113798799G>C	uc003eay.2	+	8	1023	c.793G>C	c.(793-795)GAA>CAA	p.E265Q	QTRTD1_uc003eaz.2_Missense_Mutation_p.E277Q|QTRTD1_uc011biq.1_Missense_Mutation_p.E142Q|QTRTD1_uc011bir.1_Missense_Mutation_p.E159Q	NM_024638	NP_078914	Q9H974	QTRD1_HUMAN	queuine tRNA-ribosyltransferase domain	265					queuosine biosynthetic process	mitochondrion	metal ion binding|queuine tRNA-ribosyltransferase activity			central_nervous_system(1)|skin(1)	2						CGAGTGTATTGAAAGAGGAGT	0.433													21	155					0	0	0	0	C	113798799	C	C	113798799	3	2	130	1	0	0	0	0	1	0	0	0	12951	1291	45	2	815	2	QTRTD1	3	113798799	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	64504875	113798799	84223631	63	23295											
CCDC58	131076	broad.mit.edu	37	chr3	122090639	122090639	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaattgtcctcatcaccttGagtaattcctatatgtattt	10	18	4	9	0	3	1	3	1	0	0	5	1	5	1	3	0	0	2	3	0	5	8			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr3:122090639G>C	uc003eey.2	-	2	63	c.60C>G	c.(58-60)CTC>CTG	p.L20L		NM_001017928	NP_001017928	Q4VC31	CCD58_HUMAN	coiled-coil domain containing 58	20											0				GBM - Glioblastoma multiforme(114;0.148)		TCATCACCTTGAGTAATTCCT	0.318													8	63					0	0	0	0	C	122090639	C	C	122090639	2	2	130	1	0	0	0	0	0	0	0	1	2841	1277	45	2		2	CCDC58	3	122090639	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	8291840	122090639	75931791	64	23296											
PAQR9	344838	broad.mit.edu	37	chr3	142681168	142681168	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggtgcggcaggcggcgcctgGaggaactggcgcaggccctc	5	4	19	13	4	0	0	0	0	0	0	1	2	0	2	2	8	2	2	2	8	1	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr3:142681168G>C	uc003evg.2	-	1	1011	c.1011C>G	c.(1009-1011)CTC>CTG	p.L337L	PAQR9_uc003evf.1_RNA	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	337	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						GCGGCGCCTGGAGGAACTGGC	0.582													17	123					0	0	0	0	C	142681168	C	C	142681168	2	2	130	1	0	0	0	0	0	0	0	1	11496	1161	41	2		2	PAQR9	3	142681168	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	20590529	142681168	55341262	65	23297											
PLSCR5	389158	broad.mit.edu	37	chr3	146307603	146307603	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcattaatggttttcaccTttagaaagaaaataaggagt	15	15	7	4	0	2	2	2	0	0	2	2	3	2	3	1	2	0	1	1	2	6	7			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr3:146307603T>A	uc003ewb.2	-	6	1620	c.616_splice	c.e6-1	p.V206_splice	PLSCR5_uc010hvb.2_Splice_Site_p.V194_splice|PLSCR5_uc010hvc.2_Splice_Site_p.V206_splice	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5												0						GGTTTTCACCTTTAGAAAGAA	0.299													4	110					0	0	0	0	A	146307603	A	A	146307603	5	1	130	1	0	0	0	0	0	0	1	0	12168	1623	56	5	209	5	PLSCR5	3	146307603	Splice_Site	SNP	T	TCGA-CR-6484-01A-11D-1870-08	3626435	146307603	51714827	66	23298											
TM4SF18	116441	broad.mit.edu	37	chr3	149039271	149039271	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattttgtccttattcaaatGattccaggctataggaaaaa	14	14	6	7	0	1	1	1	1	0	0	3	2	3	2	2	2	0	1	2	2	6	7			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr3:149039271G>A	uc003exa.2	-	6	737	c.600C>T	c.(598-600)ATC>ATT	p.I200I		NM_138786	NP_620141	Q96CE8	T4S18_HUMAN	transmembrane 4 L six family member 18	200	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TTATTCAAATGATTCCAGGCT	0.303													13	109					0	0	0	0	A	149039271	A	A	149039271	2	1	130	1	0	0	0	0	0	0	0	1	16033	1280	45	2		2	TM4SF18	3	149039271	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2731668	149039271	48983159	67	23299											
PTX3	5806	broad.mit.edu	37	chr3	157160249	157160249	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcttgagtcttttagtgcCtgcatttgggtcaaagccac	8	13	11	9	0	2	1	1	1	1	0	2	1	2	1	2	2	3	2	2	2	2	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr3:157160249C>T	uc003fbl.3	+	3	770	c.627C>T	c.(625-627)GCC>GCT	p.A209A	VEPH1_uc003fbj.1_Intron|VEPH1_uc003fbk.1_Intron|VEPH1_uc010hvu.1_Intron	NM_002852	NP_002843	P26022	PTX3_HUMAN	pentraxin 3 precursor	209	Pentaxin.				inflammatory response	extracellular region				central_nervous_system(1)	1			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CTTTTAGTGCCTGCATTTGGG	0.423													15	86					0	0	0	0	T	157160249	T	T	157160249	2	4	130	1	0	0	0	0	0	0	0	1	12887	668	24	4		4	PTX3	3	157160249	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	8120978	157160249	40862181	68	23300											
FAM43A	131583	broad.mit.edu	37	chr3	194408636	194408636	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgcaacttattagcgacctgGgcgagctcagcttcggcaac	9	8	11	13	4	1	0	1	0	0	0	2	2	1	0	1	2	5	4	1	2	4	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr3:194408636G>T	uc003fuj.2	+	1	2015	c.1081G>T	c.(1081-1083)GGC>TGC	p.G361C		NM_153690	NP_710157	Q8N2R8	FA43A_HUMAN	hypothetical protein LOC131583	361										central_nervous_system(1)	1	all_cancers(143;2.04e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.147)	OV - Ovarian serous cystadenocarcinoma(49;8.37e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.78e-05)		TAGCGACCTGGGCGAGCTCAG	0.527													4	15					0.00909568	0.00931934	1	0	T	194408636	T	T	194408636	3	4	130	1	0	0	0	0	1	0	0	0	5594	1232	43	4	1083	4	FAM43A	3	194408636	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	37248387	194408636	3613794	69	23301											
ZCCHC4	29063	broad.mit.edu	37	chr4	25351204	25351204	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccgtttggtggcttggttGaacctctggctattacattc	5	16	10	10	1	1	1	0	1	1	0	3	1	2	1	2	4	2	4	2	4	3	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr4:25351204G>C	uc003grl.3	+	7	886	c.850G>C	c.(850-852)GAA>CAA	p.E284Q	ZCCHC4_uc003grm.1_RNA|ZCCHC4_uc003grn.3_Missense_Mutation_p.E50Q	NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	284							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				TGGCTTGGTTGAACCTCTGGC	0.378													28	152					0	0	0	0	C	25351204	C	C	25351204	3	2	130	1	0	0	0	0	1	0	0	0	17657	1291	45	2	876	2	ZCCHC4	4	25351204	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08		25351204	165803072	70	23302											
RHOH	399	broad.mit.edu	37	chr4	40245288	40245288	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cataactcattcctgaacttGaagaacaagtggattggtga	14	11	9	7	0	1	4	1	3	0	1	2	5	2	5	1	2	3	0	1	2	5	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr4:40245288G>A	uc003guz.2	+	3	1006	c.282G>A	c.(280-282)TTG>TTA	p.L94L		NM_004310	NP_004301	Q15669	RHOH_HUMAN	ras homolog gene family, member H precursor	94					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			ovary(1)|lung(1)	2						TCCTGAACTTGAAGAACAAGT	0.572													14	32					0	0	0	0	A	40245288	A	A	40245288	2	1	130	1	0	0	0	0	0	0	0	1	13405	1281	45	2		2	RHOH	4	40245288	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	14894084	40245288	150908988	71	23303											
LIMCH1	22998	broad.mit.edu	37	chr4	41648692	41648692	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tatcctccttcctgaatgacCccaatcccatgaaatacctg	11	11	4	15	0	0	3	0	3	0	0	4	3	4	3	7	0	1	0	7	0	5	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr4:41648692C>T	uc003gvu.3	+	12	1501	c.1447C>T	c.(1447-1449)CCC>TCC	p.P483S	LIMCH1_uc003gvv.3_Missense_Mutation_p.P483S|LIMCH1_uc003gvw.3_Missense_Mutation_p.P483S|LIMCH1_uc003gvx.3_Missense_Mutation_p.P471S|LIMCH1_uc003gwe.3_Missense_Mutation_p.P483S|LIMCH1_uc003gvy.3_Missense_Mutation_p.P312S|LIMCH1_uc003gwa.3_Missense_Mutation_p.P324S|LIMCH1_uc003gvz.3_Missense_Mutation_p.P868S|LIMCH1_uc011byu.1_Missense_Mutation_p.P317S|LIMCH1_uc003gwc.3_Missense_Mutation_p.P329S|LIMCH1_uc003gwd.3_Missense_Mutation_p.P317S|LIMCH1_uc011byv.1_Missense_Mutation_p.P234S	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	483					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						CCTGAATGACCCCAATCCCAT	0.488													33	320					0	0	0	0	T	41648692	T	T	41648692	3	4	130	1	0	0	0	0	1	0	0	0	8838	623	22	4	1521	4	LIMCH1	4	41648692	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1403404	41648692	149505584	72	23304											
ANKRD50	57182	broad.mit.edu	37	chr4	125592795	125592795	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcattagccaataatgttCtcccatttgaatcacactga	13	12	5	11	0	2	2	1	2	1	0	3	2	2	2	2	0	2	2	2	0	4	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr4:125592795C>T	uc003ifg.3	-	3	1903	c.1637G>A	c.(1636-1638)AGA>AAA	p.R546K	ANKRD50_uc011cgo.1_Missense_Mutation_p.R367K|ANKRD50_uc010inw.2_Missense_Mutation_p.R546K	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	546	ANK 3.									central_nervous_system(1)	1						CAATAATGTTCTCCCATTTGA	0.398													6	64					0	0	0	0	T	125592795	T	T	125592795	3	4	130	1	0	0	0	0	1	0	0	0	677	913	32	2	2656	2	ANKRD50	4	125592795	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	83944103	125592795	65561481	73	23305											
SPEF2	79925	broad.mit.edu	37	chr5	35806816	35806816	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaactttgcagacctcctCaactgatgcaggtccagctg	9	12	8	12	0	1	2	1	1	0	1	3	2	3	2	3	1	5	3	3	1	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:35806816C>G	uc003jjo.2	+	35	5129	c.5018C>G	c.(5017-5019)TCA>TGA	p.S1673*	SPEF2_uc003jjp.1_Nonsense_Mutation_p.S1159*|SPEF2_uc003jjr.2_Nonsense_Mutation_p.S728*	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1673					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAGACCTCCTCAACTGATGCA	0.388													5	29					0	0	0	0	G	35806816	G	G	35806816	4	3	130	1	0	0	0	0	0	1	0	0	15101	838	29	2	5177	2	SPEF2	5	35806816	Nonsense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08		35806816	145108444	74	23306											
DHX29	54505	broad.mit.edu	37	chr5	54591224	54591224	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccttactcttagggtcctCttcatatgtttttgttttag	6	21	6	8	0	3	0	1	0	2	0	4	0	4	0	2	1	2	2	2	1	5	9			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:54591224C>G	uc003jpx.2	-	5	754	c.634G>C	c.(634-636)GAG>CAG	p.E212Q	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	212							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TTAGGGTCCTCTTCATATGTT	0.333													11	85					0	0	0	0	G	54591224	G	G	54591224	3	3	130	1	0	0	0	0	1	0	0	0	4525	922	32	2	3567	2	DHX29	5	54591224	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	18784408	54591224	126324036	75	23307											
MAP3K1	4214	broad.mit.edu	37	chr5	56179360	56179360	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtttaatatgtagacaccaGagactctaccaggacatacc	14	9	7	11	1	1	2	0	0	1	2	1	4	1	3	3	1	2	2	3	1	5	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:56179360G>C	uc003jqw.3	+	15	4174	c.3673G>C	c.(3673-3675)GAG>CAG	p.E1225Q		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	1225					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GTAGACACCAGAGACTCTACC	0.368													3	56					0	0	0	0	C	56179360	C	C	56179360	3	2	130	1	0	0	0	0	1	0	0	0	9296	943	33	2	3731	2	MAP3K1	5	56179360	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1588136	56179360	124735900	76	23308											
HTR1A	3350	broad.mit.edu	37	chr5	63256583	63256583	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gttgcgctcatttttcctctCgaaagaggcgggggcacaag	8	10	13	10	3	2	1	1	0	1	1	4	2	3	1	1	3	1	3	1	3	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:63256583C>G	uc011cqt.1	-	1	964	c.964G>C	c.(964-966)GAG>CAG	p.E322Q		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	322	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TTTTTCCTCTCGAAAGAGGCG	0.617													4	51					0	0	0	0	G	63256583	G	G	63256583	3	3	130	1	0	0	0	0	1	0	0	0	7475	893	31	3	307	3	HTR1A	5	63256583	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	7077223	63256583	117658677	77	23309											
XRCC4	7518	broad.mit.edu	37	chr5	82400809	82400809	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcattttctacaagtatcttGggagaaaacactggaatctg	13	13	8	7	0	4	1	1	0	3	1	4	3	4	2	0	2	2	1	0	2	6	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:82400809G>C	uc003kib.2	+	2	199	c.71G>C	c.(70-72)TGG>TCG	p.W24S	XRCC4_uc003kia.1_Missense_Mutation_p.W24S|XRCC4_uc003kid.2_Missense_Mutation_p.W24S|XRCC4_uc003kic.2_Missense_Mutation_p.W24S|XRCC4_uc003kie.2_Missense_Mutation_p.W24S|XRCC4_uc003kif.1_Missense_Mutation_p.W24S	NM_022406	NP_071801	Q13426	XRCC4_HUMAN	X-ray repair cross complementing protein 4	24					DNA ligation involved in DNA repair|double-strand break repair via nonhomologous end joining|initiation of viral infection|positive regulation of ligase activity|provirus integration|response to X-ray	cytosol|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|nucleoplasm	DNA binding|protein C-terminus binding			skin(3)	3		Lung NSC(167;0.00132)|all_lung(232;0.00154)|Ovarian(174;0.034)		OV - Ovarian serous cystadenocarcinoma(54;1.44e-38)|Epithelial(54;3.72e-33)|all cancers(79;9.22e-28)		CAAGTATCTTGGGAGAAAACA	0.338								NHEJ					10	110					0	0	0	0	C	82400809	C	C	82400809	3	2	130	1	0	0	0	0	1	0	0	0	17523	1357	47	4	73	4	XRCC4	5	82400809	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	19144226	82400809	98514451	78	23310											
APC	324	broad.mit.edu	37	chr5	112175987	112175987	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaaaggacctattagatGattcagatgatgatgatatt	15	13	9	4	0	1	7	1	5	0	2	1	8	1	8	1	1	0	0	1	1	5	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:112175987G>T	uc010jby.2	+	16	5076	c.4696G>T	c.(4696-4698)GAT>TAT	p.D1566Y	APC_uc011cvt.1_Missense_Mutation_p.D1548Y|APC_uc003kpz.3_Missense_Mutation_p.D1566Y|APC_uc003kpy.3_Missense_Mutation_p.D1566Y|APC_uc010jbz.2_Missense_Mutation_p.D1283Y|APC_uc010jca.2_Missense_Mutation_p.D866Y	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1566	Ser-rich.|Asp/Glu-rich (acidic).				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CCTATTAGATGATTCAGATGA	0.363		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			12	83					0.00010058	0.000105356	1	0	T	112175987	T	T	112175987	3	4	130	1	0	0	0	0	1	0	0	0	763	1290	45	2	4754	2	APC	5	112175987	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	29775178	112175987	68739273	79	23311											
ZNF608	57507	broad.mit.edu	37	chr5	123984449	123984449	+	Frame_Shift_Del	DEL	A	-	-																															gagaagagcagccttggtccAaaaaagtagtctctggtttc																										TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:123984449delA	uc003ktq.1	-	4	1751	c.1628delT	c.(1627-1629)TTGfs	p.L543fs	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Frame_Shift_Del_p.L543fs|ZNF608_uc003ktt.1_Frame_Shift_Del_p.L543fs	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	543						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCCTTGGTCCAAAAAAGTAGT	0.502													---	---	---								-	123984449	-	-	123984449	7	5	130	1	0	1	0	1	0	0	0	0	18101	131	5	0	2934	0	ZNF608	5	123984449	Frame_Shift_Del	DEL	A	TCGA-CR-6484-01A-11D-1870-08	11808462	123984449	56930811	80	23312											
GRAMD3	65983	broad.mit.edu	37	chr5	125821386	125821386	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctcccaacaggtctgtcaGaaactgttggaatcttacat	11	12	7	11	0	3	1	1	0	2	1	5	2	5	2	2	2	3	1	2	2	4	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:125821386G>C	uc003ktu.2	+	11	1409	c.979G>C	c.(979-981)GAA>CAA	p.E327Q	GRAMD3_uc011cwt.1_Missense_Mutation_p.E342Q|GRAMD3_uc011cwv.1_Missense_Mutation_p.E335Q|GRAMD3_uc011cww.1_Missense_Mutation_p.E223Q|GRAMD3_uc011cwx.1_RNA|GRAMD3_uc011cwy.1_Missense_Mutation_p.E218Q|GRAMD3_uc011cwz.1_Missense_Mutation_p.E311Q	NM_023927	NP_076416	Q96HH9	GRAM3_HUMAN	GRAM domain containing 3 isoform 2	327										central_nervous_system(1)	1		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0401)|OV - Ovarian serous cystadenocarcinoma(64;0.0604)|all cancers(49;0.108)		AGGTCTGTCAGAAACTGTTGG	0.353													6	60					0	0	0	0	C	125821386	C	C	125821386	3	2	130	1	0	0	0	0	1	0	0	0	6790	943	33	2	1235	2	GRAMD3	5	125821386	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1836937	125821386	55093874	81	23313											
RAD50	10111	broad.mit.edu	37	chr5	131953875	131953875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcattttaagaaagaacttcGagaaccacaatttcgggatg	15	11	8	7	2	1	3	1	0	0	3	3	5	1	4	1	1	2	0	1	1	5	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:131953875G>A	uc003kxi.2	+	21	3665	c.3278G>A	c.(3277-3279)CGA>CAA	p.R1093Q	RAD50_uc003kxh.2_Missense_Mutation_p.R954Q	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	1093					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAAGAACTTCGAGAACCACAA	0.323								Homologous_recombination					32	187					0	0	0	0	A	131953875	A	A	131953875	3	1	130	1	0	0	0	0	1	0	0	0	13049	1058	37	1	3360	1	RAD50	5	131953875	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6132489	131953875	48961385	82	23314											
PCDH1	5097	broad.mit.edu	37	chr5	141244811	141244811	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactcttggggttggtgcctCggtccttagcaagcactgag	6	11	13	11	1	1	1	0	1	1	0	3	1	2	1	2	4	3	3	2	4	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:141244811C>T	uc003llq.2	-	3	1202	c.1085G>A	c.(1084-1086)CGA>CAA	p.R362Q	PCDH1_uc003llp.2_Missense_Mutation_p.R362Q|PCDH1_uc011dbf.1_Missense_Mutation_p.R340Q	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	362	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GTTGGTGCCTCGGTCCTTAGC	0.582													14	102					0	0	0	0	T	141244811	T	T	141244811	3	4	130	1	0	0	0	0	1	0	0	0	11560	884	31	1	2724	1	PCDH1	5	141244811	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	9290936	141244811	39670449	83	23315											
KIAA0141	9812	broad.mit.edu	37	chr5	141307791	141307791	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccctgccagcaggacctcagCgggtagaacactgctcctgg	8	6	12	15	1	1	1	1	0	0	1	2	2	2	2	4	3	5	3	4	3	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:141307791C>T	uc003lls.2	+	4	462	c.340C>T	c.(340-342)CGG>TGG	p.R114W	KIAA0141_uc003llt.2_Missense_Mutation_p.R114W	NM_001142603	NP_001136075	Q14154	DELE_HUMAN	hypothetical protein LOC9812 precursor	114					apoptosis|regulation of caspase activity	mitochondrion	protein binding			skin(1)	1		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGACCTCAGCGGGTAGAACA	0.612													11	67					0	0	0	0	T	141307791	T	T	141307791	3	4	130	1	0	0	0	0	1	0	0	0	8195	759	27	1	354	1	KIAA0141	5	141307791	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	62980	141307791	39607469	84	23316											
ZNF300	91975	broad.mit.edu	37	chr5	150276107	150276107	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactccattgtgaatcttctCaagattagaattgggctcac	11	14	7	9	0	3	3	2	1	2	2	5	3	4	3	1	1	1	1	1	1	5	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:150276107C>G	uc003lsy.1	-	6	961	c.694G>C	c.(694-696)GAG>CAG	p.E232Q	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAATCTTCTCAAGATTAGAA	0.353													22	121					0	0	0	0	G	150276107	G	G	150276107	3	3	130	1	0	0	0	0	1	0	0	0	17898	835	29	2	1124	2	ZNF300	5	150276107	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	8968316	150276107	30639153	85	23317											
KIF4B	285643	broad.mit.edu	37	chr5	154393495	154393495	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtccccaaagagattagcGagggctgccagatgtgcctt	9	9	13	10	1	0	2	0	0	0	2	1	4	1	2	4	2	3	1	4	2	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:154393495G>A	uc010jih.1	+	1	236	c.76G>A	c.(76-78)GAG>AAG	p.E26K		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	26	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGAGATTAGCGAGGGCTGCCA	0.522													22	44					0	0	0	0	A	154393495	A	A	154393495	3	1	130	1	0	0	0	0	1	0	0	0	8343	1059	37	1	78	1	KIF4B	5	154393495	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	4117388	154393495	26521765	86	23318											
GABRB2	2561	broad.mit.edu	37	chr5	160721121	160721121	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaagccaatagacgatgttGaagaaggaaaaaaccactgg	19	6	10	6	1	0	3	0	1	0	2	0	5	0	4	2	2	2	1	2	2	9	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:160721121G>C	uc003lys.1	-	11	1724	c.1506C>G	c.(1504-1506)TTC>TTG	p.F502L	GABRB2_uc011deh.1_Missense_Mutation_p.F303L|GABRB2_uc003lyr.1_Missense_Mutation_p.F464L|GABRB2_uc003lyt.1_Missense_Mutation_p.F464L|GABRB2_uc010jiu.1_Missense_Mutation_p.F401L	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	502	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGACGATGTTGAAGAAGGAAA	0.468													7	55					0	0	0	0	C	160721121	C	C	160721121	3	2	130	1	0	0	0	0	1	0	0	0	6201	1281	45	2	36	2	GABRB2	5	160721121	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6327626	160721121	20194139	87	23319											
FGFR4	2264	broad.mit.edu	37	chr5	176519745	176519745	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcctcgcaggcaattccatCggcctctcctaccagtctgc	6	10	8	17	2	2	0	0	0	2	0	6	0	3	0	5	2	3	2	5	2	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:176519745C>T	uc003mfl.2	+	8	1184	c.1017C>T	c.(1015-1017)ATC>ATT	p.I339I	FGFR4_uc003mfm.2_Silent_p.I339I|FGFR4_uc011dfu.1_Silent_p.I339I|FGFR4_uc011dfw.1_Silent_p.I339I|FGFR4_uc003mfo.2_Silent_p.I339I	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	339	Extracellular (Potential).|Ig-like C2-type 3.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GCAATTCCATCGGCCTCTCCT	0.632										TSP Lung(9;0.080)			4	52					0	0	0	0	T	176519745	T	T	176519745	2	4	130	1	0	0	0	0	0	0	0	1	5900	874	31	1		1	FGFR4	5	176519745	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	15798624	176519745	4395515	88	23320											
RGS14	10636	broad.mit.edu	37	chr5	176794747	176794747	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagcccgggaagtcgctgccGctgggtgtggaggagttggg	6	7	20	8	3	0	0	0	0	0	0	1	3	0	3	2	5	2	3	2	5	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr5:176794747G>A	uc003mgf.2	+	7	842	c.660G>A	c.(658-660)CCG>CCA	p.P220P	RGS14_uc003mgg.1_Silent_p.P67P|RGS14_uc003mgh.2_Silent_p.P67P|RGS14_uc003mgi.2_5'UTR	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	220					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGTCGCTGCCGCTGGGTGTGG	0.711													6	34					0	0	0	0	A	176794747	A	A	176794747	2	1	130	1	0	0	0	0	0	0	0	1	13362	1074	38	1		1	RGS14	5	176794747	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	275002	176794747	4120513	89	23321											
NUP153	9972	broad.mit.edu	37	chr6	17637953	17637953	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtataaactactgggcttGttgcggtgggctgagcagca	8	12	14	7	1	0	1	0	1	0	0	0	1	0	1	0	3	5	6	0	3	4	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:17637953G>C	uc003ncd.1	-	16	2095	c.1895C>G	c.(1894-1896)ACA>AGA	p.T632R	NUP153_uc011dje.1_Missense_Mutation_p.T663R|NUP153_uc010jpl.1_Missense_Mutation_p.T590R	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	632					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TACTGGGCTTGTTGCGGTGGG	0.438													10	80					0	0	0	0	C	17637953	C	C	17637953	3	2	130	1	0	0	0	0	1	0	0	0	10809	1377	48	4	2560	4	NUP153	6	17637953	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08		17637953	153477114	90	23322											
HIST1H2BF	8343	broad.mit.edu	37	chr6	26200015	26200015	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcttcgagcgcatcgctggcGaggcttcccgcctggcgcat	4	9	13	15	6	1	0	0	0	1	0	4	2	2	0	2	3	1	4	2	3	0	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:26200015G>A	uc003ngx.2	+	1	229	c.229G>A	c.(229-231)GAG>AAG	p.E77K	HIST1H3D_uc003ngv.2_5'Flank|HIST1H2AD_uc003ngw.2_5'Flank	NM_003522	NP_003513	P62807	H2B1C_HUMAN	histone cluster 1, H2bf	77					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0		all_hematologic(11;0.196)				CATCGCTGGCGAGGCTTCCCG	0.612													11	155					0	0	0	0	A	26200015	A	A	26200015	3	1	130	1	0	0	0	0	1	0	0	0	7184	1059	37	1	231	1	HIST1H2BF	6	26200015	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	8562062	26200015	144915052	91	23323											
BTN1A1	696	broad.mit.edu	37	chr6	26505360	26505360	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgatcatcagagacacttCtgcgaaaaatgtgtcctgct	12	11	9	9	1	3	2	2	1	1	1	4	4	4	2	1	0	2	1	1	0	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:26505360C>G	uc003nif.3	+	3	655	c.635C>G	c.(634-636)TCT>TGT	p.S212C		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	212	Extracellular (Potential).|Ig-like V-type 2.					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						AGAGACACTTCTGCGAAAAAT	0.448													11	71					0	0	0	0	G	26505360	G	G	26505360	3	3	130	1	0	0	0	0	1	0	0	0	1564	913	32	2	645	2	BTN1A1	6	26505360	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	305345	26505360	144609707	92	23324											
PGBD1	84547	broad.mit.edu	37	chr6	28269871	28269871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taaaatggatcaaattatttCgaaatacagggtgaggataa	18	11	9	3	1	1	1	1	1	0	0	2	4	1	3	0	3	1	0	0	3	7	5	rs147237521	byFrequency	TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:28269871C>T	uc003nky.2	+	7	2610	c.2240C>T	c.(2239-2241)TCG>TTG	p.S747L	PGBD1_uc003nkz.2_Missense_Mutation_p.S747L	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	747					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						CAAATTATTTCGAAATACAGG	0.388													8	52					0	0	0	0	T	28269871	T	T	28269871	3	4	130	1	0	0	0	0	1	0	0	0	11835	893	31	1	2262	1	PGBD1	6	28269871	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1764511	28269871	142845196	93	23325											
OR2H1	26716	broad.mit.edu	37	chr6	29430385	29430385	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcttctatgcagtgggcaCtccttcacttaaccctctcg	6	14	6	15	1	4	0	1	0	3	0	7	0	5	0	2	1	2	2	2	1	2	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:29430385C>G	uc003nmi.2	+	3	1282	c.839C>G	c.(838-840)ACT>AGT	p.T280S	OR2H1_uc003nmj.1_Missense_Mutation_p.T280S|OR2H1_uc010jri.1_Missense_Mutation_p.T202S	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCAGTGGGCACTCCTTCACTT	0.512													14	91					0	0	0	0	G	29430385	G	G	29430385	3	3	130	1	0	0	0	0	1	0	0	0	11055	565	20	4	841	4	OR2H1	6	29430385	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1160514	29430385	141684682	94	23326											
TRIM10	10107	broad.mit.edu	37	chr6	30126982	30126982	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatttcttgaatctcctctCtctcttttcttagacattta	7	20	4	10	0	5	2	0	1	5	1	8	3	5	3	1	1	0	0	1	1	3	7			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:30126982C>G	uc003npo.3	-	2	546	c.470G>C	c.(469-471)AGA>ACA	p.R157T	TRIM10_uc003npn.2_Missense_Mutation_p.R157T	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	157	Potential.					cytoplasm	zinc ion binding				0						AATCTCCTCTCTCTCTTTTCT	0.423													3	61					0	0	0	0	G	30126982	G	G	30126982	3	3	130	1	0	0	0	0	1	0	0	0	16553	913	32	2	1087	2	TRIM10	6	30126982	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	696597	30126982	140988085	95	23327											
TRIM15	89870	broad.mit.edu	37	chr6	30131831	30131831	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttcctggacgaggccattCagccctaccgggtaagaagt	9	8	13	11	2	1	1	1	0	0	1	2	3	2	2	4	4	2	2	4	4	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:30131831C>G	uc010jrx.2	+	1	849	c.370C>G	c.(370-372)CAG>GAG	p.Q124E		NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15	124					mesodermal cell fate determination	intracellular	zinc ion binding				0						CGAGGCCATTCAGCCCTACCG	0.577													11	42					0	0	0	0	G	30131831	G	G	30131831	3	3	130	1	0	0	0	0	1	0	0	0	16557	827	29	2	372	2	TRIM15	6	30131831	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	4849	30131831	140983236	96	23328											
HSPA1L	3305	broad.mit.edu	37	chr6	31778792	31778792	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcatcccgaagcgctttttCtacaggctccagggtacccc	7	9	10	15	2	1	0	0	0	1	0	3	1	3	0	4	3	3	4	4	3	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:31778792C>T	uc003nxh.2	-	2	1141	c.958G>A	c.(958-960)GAA>AAA	p.E320K	HSPA1L_uc010jte.2_Missense_Mutation_p.E320K	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	320					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						AGCGCTTTTTCTACAGGCTCC	0.488													10	65					0	0	0	0	T	31778792	T	T	31778792	3	4	130	1	0	0	0	0	1	0	0	0	7449	922	32	2	971	2	HSPA1L	6	31778792	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1646961	31778792	139336275	97	23329											
KIFC1	3833	broad.mit.edu	37	chr6	33371665	33371665	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagcttcaggaccagctcaGagatgcccagcagcaggtca	11	5	12	13	0	3	1	3	0	0	1	3	3	3	2	2	2	5	5	2	2	0	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:33371665G>C	uc003oef.3	+	6	965	c.515G>C	c.(514-516)AGA>ACA	p.R172T	KIFC1_uc011drf.1_Missense_Mutation_p.R164T	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	172	Potential.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						GACCAGCTCAGAGATGCCCAG	0.557													12	91					0	0	0	0	C	33371665	C	C	33371665	3	2	130	1	0	0	0	0	1	0	0	0	8351	942	33	2	537	2	KIFC1	6	33371665	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1592873	33371665	137743402	98	23330											
KCNK16	83795	broad.mit.edu	37	chr6	39284586	39284586	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagtccccaaagccaatggtGctgagagtgatgaaagcaaa	15	7	11	8	0	0	3	0	3	0	1	1	4	1	3	3	1	3	2	3	1	5	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:39284586G>T	uc003ooq.2	-	4	647	c.633C>A	c.(631-633)AGC>AGA	p.S211R	KCNK17_uc003ooo.2_5'Flank|KCNK17_uc003oop.2_5'Flank|KCNK16_uc003oor.3_Missense_Mutation_p.S211R|KCNK16_uc010jwy.2_Missense_Mutation_p.S211R|KCNK16_uc011dtz.1_Missense_Mutation_p.S211R	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	211						integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						AGCCAATGGTGCTGAGAGTGA	0.532													36	247					4.46736e-08	4.82784e-08	1	0	T	39284586	T	T	39284586	3	4	130	1	0	0	0	0	1	0	0	0	8102	1310	46	4	693	4	KCNK16	6	39284586	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	5912921	39284586	131830481	99	23331											
ZNF451	26036	broad.mit.edu	37	chr6	57015615	57015615	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcaaacttttttggtcatCtaccagggcatctaaaccaa	12	12	7	10	0	4	0	2	0	2	0	4	0	4	0	2	3	3	1	2	3	5	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:57015615C>T	uc003pdm.1	+	11	2931	c.2707C>T	c.(2707-2709)CTA>TTA	p.L903L	ZNF451_uc003pdl.2_Silent_p.L903L|ZNF451_uc003pdn.1_Intron|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Silent_p.L903L	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	903					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TTTTGGTCATCTACCAGGGCA	0.358													17	106					0	0	0	0	T	57015615	T	T	57015615	2	4	130	1	0	0	0	0	0	0	0	1	17989	912	32	2		2	ZNF451	6	57015615	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	17731029	57015615	114099452	100	23332											
KIAA1009	22832	broad.mit.edu	37	chr6	84895136	84895136	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttacccattacagccccttCttcttcagaactaagttgag	10	14	5	12	0	3	2	1	1	2	1	3	2	3	2	3	0	4	1	3	0	4	8			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:84895136C>G	uc010kbp.2	-	13	1529	c.1432G>C	c.(1432-1434)GAA>CAA	p.E478Q	KIAA1009_uc003pkj.3_Missense_Mutation_p.E402Q|KIAA1009_uc003pkk.2_Missense_Mutation_p.E478Q|KIAA1009_uc003pki.3_5'UTR	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	478					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		ACAGCCCCTTCTTCTTCAGAA	0.363													9	96					0	0	0	0	G	84895136	G	G	84895136	3	3	130	1	0	0	0	0	1	0	0	0	8242	922	32	2	2839	2	KIAA1009	6	84895136	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	27879521	84895136	86219931	101	23333											
GPR63	81491	broad.mit.edu	37	chr6	97247016	97247016	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcccaagaaactgcaatcaGaaccttagctctatatgggt	13	10	8	10	0	2	2	1	0	1	2	2	2	2	2	2	1	5	2	2	1	7	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:97247016G>A	uc010kcl.2	-	3	1070	c.592C>T	c.(592-594)CTG>TTG	p.L198L	GPR63_uc003pou.2_Silent_p.L198L	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	198	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		ACTGCAATCAGAACCTTAGCT	0.458													5	109					0	0	0	0	A	97247016	A	A	97247016	2	1	130	1	0	0	0	0	0	0	0	1	6742	933	33	2		2	GPR63	6	97247016	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	12351880	97247016	73868051	102	23334											
LAMA4	3910	broad.mit.edu	37	chr6	112537671	112537671	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaatccagcattgcatttCtgcaacagacacaccaaacc	16	7	5	13	0	1	2	0	0	1	2	2	2	2	2	3	0	5	3	3	0	4	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:112537671C>T	uc003pvu.2	-	3	505	c.196_splice	c.e3-1	p.K66_splice	LAMA4_uc003pvv.2_Splice_Site_p.K66_splice|LAMA4_uc003pvt.2_Splice_Site_p.K66_splice|LAMA4_uc003pvw.2_Splice_Site_p.K66_splice	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor						cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CATTGCATTTCTGCAACAGAC	0.393													9	40					0	0	0	0	T	112537671	T	T	112537671	5	4	130	1	0	0	0	0	0	0	1	0	8648	927	32	2	5424	2	LAMA4	6	112537671	Splice_Site	SNP	C	TCGA-CR-6484-01A-11D-1870-08	15290655	112537671	58577396	103	23335											
ALDH8A1	64577	broad.mit.edu	37	chr6	135239804	135239804	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttcaatcacctcctcttCactatcaaaggggacgacac	11	11	5	14	1	6	0	4	0	2	0	7	2	7	1	2	2	0	0	2	2	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:135239804C>T	uc003qew.2	-	7	1266	c.1213G>A	c.(1213-1215)GAA>AAA	p.E405K	ALDH8A1_uc003qex.2_Missense_Mutation_p.E351K|ALDH8A1_uc010kgh.2_Missense_Mutation_p.E183K|ALDH8A1_uc011ecx.1_Missense_Mutation_p.E355K	NM_022568	NP_072090	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8A1 isoform 1	405					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		ACCTCCTCTTCACTATCAAAG	0.517													7	74					0	0	0	0	T	135239804	T	T	135239804	3	4	130	1	0	0	0	0	1	0	0	0	505	835	29	2	254	2	ALDH8A1	6	135239804	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	22702133	135239804	35875263	104	23336											
UTRN	7402	broad.mit.edu	37	chr6	144772564	144772564	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaatggaaaactgccattCagaccacagagataaaagag	19	6	9	7	0	1	4	1	1	0	3	1	6	1	5	2	1	2	0	2	1	5	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:144772564C>G	uc003qkt.2	+	17	2223	c.2131C>G	c.(2131-2133)CAG>GAG	p.Q711E	UTRN_uc010khq.1_Missense_Mutation_p.Q711E	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	711	Interaction with SYNM.|Spectrin 5.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AACTGCCATTCAGACCACAGA	0.363													7	32					0	0	0	0	G	144772564	G	G	144772564	3	3	130	1	0	0	0	0	1	0	0	0	17171	827	29	2	2197	2	UTRN	6	144772564	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	9532760	144772564	26342503	105	23337											
ARID1B	57492	broad.mit.edu	37	chr6	157522076	157522076	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcccgcctcagatgatgggcGgcccgctgcagtcgtcctcc	4	8	12	17	4	1	2	1	1	0	1	5	2	4	2	5	2	1	2	5	2	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr6:157522076G>A	uc003qqn.2	+	18	4446	c.4294G>A	c.(4294-4296)GGC>AGC	p.G1432S	ARID1B_uc003qqo.2_Missense_Mutation_p.G1392S|ARID1B_uc003qqp.2_Missense_Mutation_p.G1379S	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1437					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GATGATGGGCGGCCCGCTGCA	0.637													10	29					0	0	0	0	A	157522076	A	A	157522076	3	1	130	1	0	0	0	0	1	0	0	0	914	1116	39	1	4418	1	ARID1B	6	157522076	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	12749512	157522076	13592991	106	23338											
MICALL2	79778	broad.mit.edu	37	chr7	1477794	1477794	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cggagctccagggcgtccagCcgcctctcgatgtcctgcag	5	7	13	16	4	1	0	0	0	1	0	5	2	4	1	5	2	3	2	5	2	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:1477794C>T	uc003skj.3	-	12	2397	c.2250G>A	c.(2248-2250)CGG>CGA	p.R750R	MICALL2_uc003skh.3_5'UTR|MICALL2_uc003ski.3_Silent_p.R237R	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	750	Potential.					cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GGGCGTCCAGCCGCCTCTCGA	0.726													2	3					0	0	0	0	T	1477794	T	T	1477794	2	4	130	1	0	0	0	0	0	0	0	1	9627	726	26	4		4	MICALL2	7	1477794	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08		1477794	157660869	107	23339											
FOXK1	221937	broad.mit.edu	37	chr7	4722413	4722413	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcttccaggagccgcacttCtacctgcgctgcctcggcaa	7	8	10	16	3	1	0	0	0	1	0	3	1	2	1	4	2	5	4	4	2	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:4722413C>T	uc003snc.1	+	1	484	c.474C>T	c.(472-474)TTC>TTT	p.F158F	FOXK1_uc003sna.1_Intron|FOXK1_uc003snb.1_Silent_p.F158F	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	158	FHA.				cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		AGCCGCACTTCTACCTGCGCT	0.692													3	12					0	0	0	0	T	4722413	T	T	4722413	2	4	130	1	0	0	0	0	0	0	0	1	6048	912	32	2		2	FOXK1	7	4722413	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	3244619	4722413	154416250	108	23340											
FOXK1	221937	broad.mit.edu	37	chr7	4800700	4800700	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gttcctgtcccgcaggcctgGaggagaaacccaccattgcg	8	7	12	14	2	0	1	0	0	0	1	2	3	2	2	5	3	2	2	5	3	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:4800700G>C	uc003snc.1	+	8	1712	c.1702G>C	c.(1702-1704)GAG>CAG	p.E568Q	FOXK1_uc003sna.1_Missense_Mutation_p.E405Q	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	568					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		CGCAGGCCTGGAGGAGAAACC	0.637													9	94					0	0	0	0	C	4800700	C	C	4800700	3	2	130	1	0	0	0	0	1	0	0	0	6048	1175	41	2	1732	2	FOXK1	7	4800700	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	78287	4800700	154337963	109	23341											
MACC1	346389	broad.mit.edu	37	chr7	20198921	20198921	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtggcagctggtgacggaaGagctttagcttgtgcagcaa	9	9	16	7	1	0	2	0	1	0	1	0	3	0	3	0	4	5	6	0	4	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:20198921G>C	uc003sus.3	-	5	1372	c.1063C>G	c.(1063-1065)CTT>GTT	p.L355V	MACC1_uc010kug.2_Missense_Mutation_p.L355V	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	355					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						GGTGACGGAAGAGCTTTAGCT	0.398													3	67					0	0	0	0	C	20198921	C	C	20198921	3	2	130	1	0	0	0	0	1	0	0	0	9194	942	33	2	1507	2	MACC1	7	20198921	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	15398221	20198921	138939742	110	23342											
NT5C3	51251	broad.mit.edu	37	chr7	33066516	33066516	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	attcgaactgaacttttctgGaattctggcatctaaaagta	13	14	7	7	1	3	1	0	1	3	0	4	3	3	2	0	2	2	2	0	2	6	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:33066516G>A	uc003tdk.2	-	2	242	c.165C>T	c.(163-165)TTC>TTT	p.F55F	AVL9_uc011kai.1_Intron|NT5C3_uc003tdi.2_Silent_p.F16F|NT5C3_uc003tdj.2_Silent_p.F16F	NM_001002010	NP_001002010	Q9H0P0	5NT3_HUMAN	5'-nucleotidase, cytosolic III isoform 1	55					nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1			GBM - Glioblastoma multiforme(11;0.0894)			AACTTTTCTGGAATTCTGGCA	0.343													9	60					0	0	0	0	A	33066516	A	A	33066516	2	1	130	1	0	0	0	0	0	0	0	1	10742	1165	41	2		2	NT5C3	7	33066516	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	12867595	33066516	126072147	111	23343											
ELMO1	9844	broad.mit.edu	37	chr7	37172813	37172813	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcccaggtggagtctgcgtGaagtccatggcagggttgac	8	9	15	9	1	1	2	0	2	1	0	3	3	3	3	2	4	1	2	2	4	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:37172813G>A	uc003tfk.1	-	14	1420	c.1113C>T	c.(1111-1113)TTC>TTT	p.F371F	ELMO1_uc011kbc.1_Silent_p.F275F|ELMO1_uc010kxg.1_Silent_p.F371F	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	371	ELMO.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GAGTCTGCGTGAAGTCCATGG	0.468													14	141					0	0	0	0	A	37172813	A	A	37172813	2	1	130	1	0	0	0	0	0	0	0	1	5089	1281	45	2		2	ELMO1	7	37172813	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	4106297	37172813	121965850	112	23344											
C7orf36	57002	broad.mit.edu	37	chr7	39606114	39606114	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agtcgctcctggcgcagcggGaatggcagagtaacatgcaa	11	6	14	10	3	0	1	0	0	0	1	2	2	1	2	1	3	3	5	1	3	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:39606114G>C	uc003thc.3	+	1	106	c.97G>C	c.(97-99)GAA>CAA	p.E33Q		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	33											0						GGCGCAGCGGGAATGGCAGAG	0.587													5	36					0	0	0	0	C	39606114	C	C	39606114	3	2	130	1	0	0	0	0	1	0	0	0	2401	1175	41	2	99	2	C7orf36	7	39606114	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2433301	39606114	119532549	113	23345											
CDK13	8621	broad.mit.edu	37	chr7	40041594	40041594	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatgaaggaaatagtgactGataaagaagatgctttggat	17	11	11	2	0	0	5	0	3	0	2	0	7	0	7	0	2	1	1	0	2	7	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:40041594G>C	uc003thh.3	+	5	2599	c.2317G>C	c.(2317-2319)GAT>CAT	p.D773H	CDK13_uc003thi.3_Missense_Mutation_p.D773H|CDK13_uc011kbf.1_Missense_Mutation_p.D159H	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	773	Protein kinase.				alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						AATAGTGACTGATAAAGAAGA	0.323													16	78					0	0	0	0	C	40041594	C	C	40041594	3	2	130	1	0	0	0	0	1	0	0	0	3144	1290	45	2	2335	2	CDK13	7	40041594	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	435480	40041594	119097069	114	23346											
CCM2	83605	broad.mit.edu	37	chr7	45113081	45113081	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttccctgaatctgtggatGtgggtggtgcatcaccccac	6	11	12	12	0	2	1	1	1	1	0	3	2	3	2	3	3	1	2	3	3	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:45113081G>A	uc003tmo.2	+	8	972	c.826G>A	c.(826-828)GTG>ATG	p.V276M	CCM2_uc003tmn.2_RNA|CCM2_uc003tmp.2_Missense_Mutation_p.V218M|CCM2_uc003tmq.2_RNA|CCM2_uc003tmr.2_Missense_Mutation_p.V185M|CCM2_uc003tms.2_Missense_Mutation_p.V297M	NM_031443	NP_113631	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2 isoform 2	276					endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding				0						ATCTGTGGATGTGGGTGGTGC	0.587									Familial_Cerebral_Cavernous_Angioma				5	30					0	0	0	0	A	45113081	A	A	45113081	3	1	130	1	0	0	0	0	1	0	0	0	2923	1377	48	4	953	4	CCM2	7	45113081	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	5071487	45113081	114025582	115	23347											
STYXL1	51657	broad.mit.edu	37	chr7	75643194	75643194	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccatactcaatggctgcttGaggcacaagatctgagagtg	11	9	12	9	0	2	3	1	2	1	2	2	4	2	3	1	2	2	3	1	2	3	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:75643194G>A	uc003uej.3	-	5	492	c.319C>T	c.(319-321)CAA>TAA	p.Q107*	STYXL1_uc011kgf.1_Intron|STYXL1_uc011kgg.1_5'UTR|STYXL1_uc003ueh.2_Intron|STYXL1_uc003uek.3_Intron|STYXL1_uc003uel.2_Nonsense_Mutation_p.Q107*|STYXL1_uc003uem.2_Nonsense_Mutation_p.Q107*|STYXL1_uc010ldg.1_Intron|STYXL1_uc010ldh.1_Nonsense_Mutation_p.Q107*|STYXL1_uc003uen.1_Nonsense_Mutation_p.Q107*	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	107	Rhodanese.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						ATGGCTGCTTGAGGCACAAGA	0.522													23	129					0	0	0	0	A	75643194	A	A	75643194	4	1	130	1	0	0	0	0	0	1	0	0	15427	1299	45	2	642	2	STYXL1	7	75643194	Nonsense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	30530113	75643194	83495469	116	23348											
SRRM3	222183	broad.mit.edu	37	chr7	75896598	75896598	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgagccccaagcaccgagacGaagggcgaaagacgggcagc	13	1	15	12	4	0	3	0	1	0	2	0	6	0	3	3	2	3	2	3	2	3	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:75896598G>A	uc010ldi.2	+	11	1062	c.853G>A	c.(853-855)GAA>AAA	p.E285K	SRRM3_uc011kgi.1_5'UTR	NM_001110199	NP_001103669			serine/arginine repetitive matrix 3												0						GCACCGAGACGAAGGGCGAAA	0.706													4	13					0	0	0	0	A	75896598	A	A	75896598	3	1	130	1	0	0	0	0	1	0	0	0	15236	1059	37	1	891	1	SRRM3	7	75896598	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	253404	75896598	83242065	117	23349											
PCLO	27445	broad.mit.edu	37	chr7	82453635	82453635	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggctgctctgactggaaTgagacttgccatgatcaatg	9	11	12	9	0	2	3	1	3	1	1	2	5	2	4	1	2	2	3	1	2	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:82453635T>C	uc003uhx.2	-	19	14802	c.14513A>G	c.(14512-14514)CAT>CGT	p.H4838R	PCLO_uc003uhv.2_Missense_Mutation_p.H4838R|PCLO_uc003uht.1_Missense_Mutation_p.H280R|PCLO_uc003uhu.1_Missense_Mutation_p.H259R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4700	Ser-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGACTGGAATGAGACTTGCC	0.433													9	38					0	0	0	0	C	82453635	C	C	82453635	3	2	130	1	0	0	0	0	1	0	0	0	11637	1464	51	5	960	5	PCLO	7	82453635	Missense_Mutation	SNP	T	TCGA-CR-6484-01A-11D-1870-08	6557037	82453635	76685028	118	23350											
AKAP9	10142	broad.mit.edu	37	chr7	91726162	91726162	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaacaaggtcgaaacttaGagcttcaggtacttcttgaa	15	10	9	7	1	2	3	1	1	1	2	3	4	2	3	0	2	4	2	0	2	7	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:91726162G>C	uc003ulg.2	+	41	10114	c.9889G>C	c.(9889-9891)GAG>CAG	p.E3297Q	AKAP9_uc003ulf.2_Missense_Mutation_p.E3289Q|AKAP9_uc003uli.2_Missense_Mutation_p.E2920Q|AKAP9_uc003ulj.2_Missense_Mutation_p.E1067Q|AKAP9_uc003ull.2_Missense_Mutation_p.E193Q	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3301	Potential.		E -> Q (in a breast cancer sample; somatic mutation).		G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding	p.E3301Q(1)		breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCGAAACTTAGAGCTTCAGGT	0.438			T	BRAF	papillary thyroid								13	72					0	0	0	0	C	91726162	C	C	91726162	3	2	130	1	0	0	0	0	1	0	0	0	459	943	33	2	10051	2	AKAP9	7	91726162	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	9272527	91726162	67412501	119	23351											
SAMD9	54809	broad.mit.edu	37	chr7	92731898	92731898	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcacttcatactctctatcTtcactttgctgttgagattc	7	19	4	11	0	5	1	3	1	2	1	7	2	5	1	0	0	2	2	0	0	2	8			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:92731898T>C	uc003umf.2	-	3	3769	c.3513A>G	c.(3511-3513)GAA>GAG	p.E1171E	SAMD9_uc003umg.2_Silent_p.E1171E	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1171						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			ACTCTCTATCTTCACTTTGCT	0.393													25	163					0	0	0	0	C	92731898	C	C	92731898	2	2	130	1	0	0	0	0	0	0	0	1	13891	1606	56	5		5	SAMD9	7	92731898	Silent	SNP	T	TCGA-CR-6484-01A-11D-1870-08	1005736	92731898	66406765	120	23352											
TAF6	6878	broad.mit.edu	37	chr7	99705659	99705659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agacaccagtgtctggacagGaagtgcgatggagccaggaa	13	5	15	8	1	1	1	0	0	1	1	1	6	1	5	2	4	2	0	2	4	2	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:99705659G>A	uc003uti.2	-	14	1627	c.1546C>T	c.(1546-1548)CCT>TCT	p.P516S	AP4M1_uc003utd.2_Intron|TAF6_uc003utg.2_Missense_Mutation_p.P438S|TAF6_uc003uth.2_Missense_Mutation_p.P573S|TAF6_uc003utk.2_Missense_Mutation_p.P516S|TAF6_uc011kji.1_Missense_Mutation_p.P553S|TAF6_uc003utj.2_Missense_Mutation_p.P506S|TAF6_uc003utl.2_Missense_Mutation_p.P506S|TAF6_uc003utm.2_Missense_Mutation_p.P516S	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	516					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTCTGGACAGGAAGTGCGATG	0.647													5	46					0	0	0	0	A	99705659	A	A	99705659	3	1	130	1	0	0	0	0	1	0	0	0	15596	1174	41	2	495	2	TAF6	7	99705659	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6973761	99705659	59433004	121	23353											
TFR2	7036	broad.mit.edu	37	chr7	100229801	100229801	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgagcactccttgagccccGaagtcctgagcattggtcac	9	9	10	13	1	1	3	1	3	0	0	3	4	3	3	4	1	3	2	4	1	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:100229801G>A	uc003uvv.1	-	7	911	c.870C>T	c.(868-870)TTC>TTT	p.F290F	TFR2_uc010lhc.1_5'UTR|TFR2_uc003uvu.1_Silent_p.F119F	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2	290	Extracellular (Potential).				cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CTTGAGCCCCGAAGTCCTGAG	0.557													18	87					0	0	0	0	A	100229801	A	A	100229801	2	1	130	1	0	0	0	0	0	0	0	1	15877	1049	37	1		1	TFR2	7	100229801	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	524142	100229801	58908862	122	23354											
PRSS1	5644	broad.mit.edu	37	chr7	142460822	142460822	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctggagtctacaccaaggTctacaactatgtgaaatgga	13	9	10	9	0	2	1	0	1	2	0	2	3	2	3	2	3	3	0	2	3	6	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:142460822T>G	uc003wak.2	+	5	712	c.695T>G	c.(694-696)GTC>GGC	p.V232G	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Missense_Mutation_p.V172G	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	232	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			TACACCAAGGTCTACAACTAT	0.488									Hereditary_Pancreatitis				16	66					0	0	0	0	G	142460822	G	G	142460822	3	3	130	1	0	0	0	0	1	0	0	0	12676	1667	58	5	713	5	PRSS1	7	142460822	Missense_Mutation	SNP	T	TCGA-CR-6484-01A-11D-1870-08	42231021	142460822	16677841	123	23355											
GIMAP8	155038	broad.mit.edu	37	chr7	150164001	150164001	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacccctgaccttttctcctCaatagcttgtgctgaagaca	9	12	6	14	0	2	3	1	2	1	1	3	3	2	3	4	0	2	2	4	0	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:150164001C>T	uc003whj.2	+	2	545	c.215C>T	c.(214-216)TCA>TTA	p.S72L		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	72						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CTTTTCTCCTCAATAGCTTGT	0.493													26	140					0	0	0	0	T	150164001	T	T	150164001	3	4	130	1	0	0	0	0	1	0	0	0	6422	838	29	2	217	2	GIMAP8	7	150164001	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	7703179	150164001	8974662	124	23356											
ATG9B	285973	broad.mit.edu	37	chr7	150713883	150713883	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaggcaggagagggtgcacGaagaggttggccaggaaggc	11	3	21	6	1	0	2	0	0	0	2	0	6	0	4	1	8	1	3	1	8	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr7:150713883G>A	uc011kvc.1	-	12	2392	c.2316C>T	c.(2314-2316)TTC>TTT	p.F772F	ATG9B_uc003wig.3_RNA	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	772	Cytoplasmic (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAGGGTGCACGAAGAGGTTGG	0.612													6	21					0	0	0	0	A	150713883	A	A	150713883	2	1	130	1	0	0	0	0	0	0	0	1	1105	1059	37	1		1	ATG9B	7	150713883	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	549882	150713883	8424780	125	23357											
DUSP26	78986	broad.mit.edu	37	chr8	33454978	33454978	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggagaccttgagctactcCgggagaagcgggccataaaa	13	5	13	10	2	0	3	0	1	0	2	1	5	1	3	3	3	3	1	3	3	4	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:33454978C>T	uc003xjp.2	-	2	389	c.56G>A	c.(55-57)CGG>CAG	p.R19Q	DUSP26_uc003xjq.2_Missense_Mutation_p.R19Q	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	19						Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		TGAGCTACTCCGGGAGAAGCG	0.557													9	51					0	0	0	0	T	33454978	T	T	33454978	3	4	130	1	0	0	0	0	1	0	0	0	4845	652	23	1	591	1	DUSP26	8	33454978	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08		33454978	112909044	126	23358											
GPR124	25960	broad.mit.edu	37	chr8	37690552	37690552	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccgaactctggctggcatCacagcctaccagtcctgcct	7	8	8	18	1	2	0	1	0	1	0	3	1	3	0	6	2	4	2	6	2	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:37690552C>G	uc003xkj.2	+	9	1485	c.1122C>G	c.(1120-1122)ATC>ATG	p.I374M	GPR124_uc010lvy.2_Missense_Mutation_p.I374M	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	374	Extracellular (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TGGCTGGCATCACAGCCTACC	0.667													15	134					0	0	0	0	G	37690552	G	G	37690552	3	3	130	1	0	0	0	0	1	0	0	0	6676	816	29	2	1135	2	GPR124	8	37690552	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	4235574	37690552	108673470	127	23359											
CHRNA6	8973	broad.mit.edu	37	chr8	42611780	42611780	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgatccaatgattagaaGatcaatttcagctttgtcat	12	17	6	6	0	3	4	3	2	0	2	4	4	4	4	1	0	1	1	1	0	4	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:42611780G>C	uc003xpj.2	-	5	608	c.562C>G	c.(562-564)CTT>GTT	p.L188V	CHRNA6_uc011lcw.1_Missense_Mutation_p.L173V	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	188	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			ATGATTAGAAGATCAATTTCA	0.363													5	68					0	0	0	0	C	42611780	C	C	42611780	3	2	130	1	0	0	0	0	1	0	0	0	3402	942	33	2	930	2	CHRNA6	8	42611780	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	4921228	42611780	103752242	128	23360											
CHD7	55636	broad.mit.edu	37	chr8	61736506	61736506	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attccatggcgctgtgtagtCattgatgaagcccacaggct	9	11	11	10	1	1	2	1	2	0	0	2	2	2	2	2	2	1	3	2	2	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:61736506C>T	uc003xue.2	+	13	3786	c.3309C>T	c.(3307-3309)GTC>GTT	p.V1103V	CHD7_uc003xuf.2_Silent_p.V216V	NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1103	Helicase ATP-binding.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GCTGTGTAGTCATTGATGAAG	0.453													13	118					0	0	0	0	T	61736506	T	T	61736506	2	4	130	1	0	0	0	0	0	0	0	1	3345	813	29	2		2	CHD7	8	61736506	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	19124726	61736506	84627516	129	23361											
VCPIP1	80124	broad.mit.edu	37	chr8	67577807	67577807	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acatttgtgaaggcgattatCcattactgcttttttagcag	10	16	8	7	1	0	1	0	1	0	0	1	2	1	1	1	1	3	2	1	1	4	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:67577807C>G	uc003xwn.2	-	1	1646	c.1387G>C	c.(1387-1389)GAT>CAT	p.D463H	SGK3_uc003xwp.2_5'Flank|C8orf44_uc003xwo.1_5'Flank	NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	463					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			AGGCGATTATCCATTACTGCT	0.453													30	233					0	0	0	0	G	67577807	G	G	67577807	3	3	130	1	0	0	0	0	1	0	0	0	17209	855	30	2	2293	2	VCPIP1	8	67577807	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	5841301	67577807	78786215	130	23362											
DCAF4L2	138009	broad.mit.edu	37	chr8	88885717	88885717	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctacctatgaacagcgaCgctgggagcagcacggcaca	13	4	12	12	3	0	1	0	1	0	0	0	3	0	2	1	2	6	5	1	2	4	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:88885717C>T	uc003ydz.2	-	1	580	c.483G>A	c.(481-483)GCG>GCA	p.A161A		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	161										ovary(1)	1						TGAACAGCGACGCTGGGAGCA	0.567													41	61					0	0	0	0	T	88885717	T	T	88885717	2	4	130	1	0	0	0	0	0	0	0	1	4289	523	19	1		1	DCAF4L2	8	88885717	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	21307910	88885717	57478305	131	23363											
OSGIN2	734	broad.mit.edu	37	chr8	90937302	90937302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaagctgtatcctgaatatCataaagtctatcatatgatg	16	13	6	6	0	3	2	2	2	1	0	4	2	4	2	1	0	1	2	1	0	9	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:90937302C>T	uc003yeg.2	+	6	1406	c.1060C>T	c.(1060-1062)CAT>TAT	p.H354Y	OSGIN2_uc003yeh.2_Missense_Mutation_p.H398Y	NM_004337	NP_004328	Q9Y236	OSGI2_HUMAN	oxidative stress induced growth inhibitor family	354					germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TCCTGAATATCATAAAGTCTA	0.368													15	131					0	0	0	0	T	90937302	T	T	90937302	3	4	130	1	0	0	0	0	1	0	0	0	11344	826	29	2	1214	2	OSGIN2	8	90937302	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	2051585	90937302	55426720	132	23364											
RGS22	26166	broad.mit.edu	37	chr8	100975155	100975155	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttcttggatcttaagaaGaattctctcctgttctaagg	9	17	7	8	0	5	2	0	0	5	2	7	3	6	3	1	2	0	1	1	2	4	7			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:100975155G>C	uc003yjb.1	-	25	3862	c.3667C>G	c.(3667-3669)CTT>GTT	p.L1223V	RGS22_uc003yja.1_Missense_Mutation_p.L1042V|RGS22_uc003yjc.1_Missense_Mutation_p.L1211V	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	1223					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ATCTTAAGAAGAATTCTCTCC	0.308													4	35					0	0	0	0	C	100975155	C	C	100975155	3	2	130	1	0	0	0	0	1	0	0	0	13370	942	33	2	139	2	RGS22	8	100975155	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	10037853	100975155	45388867	133	23365											
FAM91A1	157769	broad.mit.edu	37	chr8	124801858	124801858	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctcttggtttaggttcaGagcactggtgaaggagaagc	9	13	13	6	0	2	3	1	1	1	2	3	4	2	3	0	4	2	3	0	4	3	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:124801858G>C	uc003yqv.2	+	15	1345	c.1284G>C	c.(1282-1284)CAG>CAC	p.Q428H	FAM91A1_uc011lik.1_Missense_Mutation_p.Q428H|FAM91A1_uc011lil.1_Missense_Mutation_p.Q186H	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	428										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			TTTAGGTTCAGAGCACTGGTG	0.333													11	69					0	0	0	0	C	124801858	C	C	124801858	3	2	130	1	0	0	0	0	1	0	0	0	5683	933	33	2	1342	2	FAM91A1	8	124801858	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	23826703	124801858	21562164	134	23366											
COL22A1	169044	broad.mit.edu	37	chr8	139890087	139890087	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcggacttgggctctgaggcGatctcctccagctcctcctt	4	11	11	15	2	2	1	0	1	2	0	6	3	5	2	4	3	1	2	4	3	0	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:139890087G>A	uc003yvd.2	-	3	1011	c.564C>T	c.(562-564)ATC>ATT	p.I188I		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	188	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GCTCTGAGGCGATCTCCTCCA	0.652										HNSCC(7;0.00092)			6	34					0	0	0	0	A	139890087	A	A	139890087	2	1	130	1	0	0	0	0	0	0	0	1	3696	1048	37	1		1	COL22A1	8	139890087	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	15088229	139890087	6473935	135	23367											
C8orf31	286122	broad.mit.edu	37	chr8	144124445	144124445	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaagccacaccagaattcCtgcaattcagtgaggcagct	14	7	9	11	0	1	2	1	1	0	1	2	3	2	2	3	1	3	3	3	1	4	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr8:144124445C>G	uc003yxp.1	+	2	379	c.27C>G	c.(25-27)TCC>TCG	p.S9S	C8orf31_uc003yxq.1_RNA|C8orf31_uc003yxr.1_Intron	NM_173687	NP_775958	Q8N9H6	CH031_HUMAN	hypothetical protein LOC286122	9										ovary(1)	1	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ACCAGAATTCCTGCAATTCAG	0.582													11	116					0	0	0	0	G	144124445	G	G	144124445	2	3	130	1	0	0	0	0	0	0	0	1	2432	668	24	4		4	C8orf31	8	144124445	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	4234358	144124445	2239577	136	23368											
C9orf66	157983	broad.mit.edu	37	chr9	214662	214662	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcccgcgctcccttcggccgGaggtcggcggccccgggcag	2	4	17	18	7	0	0	0	0	0	0	3	1	1	1	5	6	0	2	5	6	0	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:214662G>A	uc003zge.3	-	1	1232	c.735C>T	c.(733-735)CTC>CTT	p.L245L	DOCK8_uc011lls.1_5'Flank|DOCK8_uc003zgf.2_5'Flank	NM_152569	NP_689782	Q5T8R8	CI066_HUMAN	hypothetical protein LOC157983	245	Arg-rich.									central_nervous_system(1)	1	all_lung(41;0.218)	all_cancers(5;2.09e-12)|all_epithelial(5;6.16e-09)|all_lung(10;1.15e-08)|Lung NSC(10;1.91e-08)|Acute lymphoblastic leukemia(5;0.00457)|all_hematologic(5;0.0332)|Breast(48;0.0646)|Prostate(43;0.137)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CCTTCGGCCGGAGGTCGGCGG	0.751													3	4					0	0	0	0	A	214662	A	A	214662	2	1	130	1	0	0	0	0	0	0	0	1	2502	1161	41	2		2	C9orf66	9	214662	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08		214662	140998769	137	23369											
GLDC	2731	broad.mit.edu	37	chr9	6605142	6605142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatacctaccccactctgatGagctctctccacgagttccg	8	11	6	16	2	2	2	0	2	2	0	5	3	4	2	5	0	3	2	5	0	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:6605142G>A	uc003zkc.2	-	6	1043	c.850C>T	c.(850-852)CAT>TAT	p.H284Y		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	284					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CCACTCTGATGAGCTCTCTCC	0.502													12	56					0	0	0	0	A	6605142	A	A	6605142	3	1	130	1	0	0	0	0	1	0	0	0	6470	1290	45	2	2292	2	GLDC	9	6605142	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6390480	6605142	134608289	138	23370											
C9orf150	286343	broad.mit.edu	37	chr9	12821469	12821469	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agtccatcaagtggatgatcGaagaaaaagccaccattacc	16	7	8	10	1	1	2	1	1	0	1	3	4	2	3	4	1	2	0	4	1	5	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:12821469G>C	uc003zkw.2	+	2	1100	c.397G>C	c.(397-399)GAA>CAA	p.E133Q		NM_203403	NP_981948	Q8IV03	CI150_HUMAN	hypothetical protein LOC286343	136											0				GBM - Glioblastoma multiforme(1;1.64e-13)		GTGGATGATCGAAGAAAAAGC	0.517													16	69					0	0	0	0	C	12821469	C	C	12821469	3	2	130	1	0	0	0	0	1	0	0	0	2474	1059	37	3	403	3	C9orf150	9	12821469	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6216327	12821469	128391962	139	23371											
SIGMAR1	10280	broad.mit.edu	37	chr9	34635701	34635701	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcataggagcgaagagtataGaagagggtgaggaagtcctg	14	6	17	4	1	0	4	0	1	0	3	1	7	1	6	1	3	1	2	1	3	6	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:34635701G>C	uc003zvb.2	-	4	674	c.600C>G	c.(598-600)TTC>TTG	p.F200L	SIGMAR1_uc003zva.3_Missense_Mutation_p.F180L|SIGMAR1_uc003zuz.2_Missense_Mutation_p.F111L|SIGMAR1_uc003zvc.2_Missense_Mutation_p.F169L|SIGMAR1_uc003zvd.2_RNA|SIGMAR1_uc011loo.1_Intron	NM_005866	NP_005857	Q99720	SGMR1_HUMAN	sigma non-opioid intracellular receptor 1	200	Cytoplasmic (Potential).				ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding				0					Dextromethorphan(DB00514)	GAAGAGTATAGAAGAGGGTGA	0.622													9	34					0	0	0	0	C	34635701	C	C	34635701	3	2	130	1	0	0	0	0	1	0	0	0	14381	933	33	2	75	2	SIGMAR1	9	34635701	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	21814232	34635701	106577730	140	23372											
FBXO10	26267	broad.mit.edu	37	chr9	37512610	37512610	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccacccgggctgtgatcctCgttgccatggctgtcacctt	4	12	10	15	2	1	1	1	1	0	0	4	1	3	1	5	2	1	3	5	2	0	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:37512610C>T	uc004aab.2	-	11	2854	c.2805G>A	c.(2803-2805)ACG>ACA	p.T935T	FBXO10_uc004aac.2_Silent_p.T951T|FBXO10_uc004aad.2_Silent_p.T485T	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	935						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		CTGTGATCCTCGTTGCCATGG	0.607													14	117					0	0	0	0	T	37512610	T	T	37512610	2	4	130	1	0	0	0	0	0	0	0	1	5758	871	31	1		1	FBXO10	9	37512610	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	2876909	37512610	103700821	141	23373											
NAA35	60560	broad.mit.edu	37	chr9	88557141	88557141	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcagtatgccagaaaaaatgGagaaaagcaatacaaactgg	20	6	9	6	0	1	2	1	0	0	2	1	3	1	2	1	2	4	2	1	2	9	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:88557141G>C	uc004aoi.3	+	2	204	c.67G>C	c.(67-69)GAG>CAG	p.E23Q	NAA35_uc004aoj.3_Missense_Mutation_p.E23Q|NAA35_uc004aok.1_Missense_Mutation_p.E23Q	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein	23					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						AGAAAAAATGGAGAAAAGCAA	0.398													12	77					0	0	0	0	C	88557141	C	C	88557141	3	2	130	1	0	0	0	0	1	0	0	0	10176	1175	41	2	69	2	NAA35	9	88557141	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	51044531	88557141	52656290	142	23374											
NCBP1	4686	broad.mit.edu	37	chr9	100412873	100412873	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taagtcccactggaaggaaaGgaagacttggtaagattctt	14	10	11	6	0	1	2	0	0	1	2	2	5	2	5	1	4	0	1	1	4	5	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:100412873G>C	uc004axq.2	+	9	1445	c.986G>C	c.(985-987)AGG>ACG	p.R329T		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	329					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				TGGAAGGAAAGGAAGACTTGG	0.378													20	149					0	0	0	0	C	100412873	C	C	100412873	3	2	130	1	0	0	0	0	1	0	0	0	10265	1000	35	4	1020	4	NCBP1	9	100412873	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	11855732	100412873	40800558	143	23375											
RABEPK	10244	broad.mit.edu	37	chr9	127982928	127982928	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatatgtctttgggggcggaGagagaggtgcccagcccgtg	7	9	17	8	2	1	2	0	0	1	2	1	4	1	2	2	4	2	0	2	4	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:127982928G>C	uc004bpi.2	+	6	648	c.475G>C	c.(475-477)GAG>CAG	p.E159Q	RABEPK_uc004bph.1_3'UTR|RABEPK_uc004bpj.2_Missense_Mutation_p.E108Q|RABEPK_uc004bpk.2_Missense_Mutation_p.E159Q|RABEPK_uc004bpl.1_Missense_Mutation_p.E108Q|RABEPK_uc004bpm.2_Missense_Mutation_p.E159Q	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	159	Kelch 3.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						TGGGGGCGGAGAGAGAGGTGC	0.587													8	60					0	0	0	0	C	127982928	C	C	127982928	3	2	130	1	0	0	0	0	1	0	0	0	13028	943	33	2	489	2	RABEPK	9	127982928	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	27570055	127982928	13230503	144	23376											
NUP214	8021	broad.mit.edu	37	chr9	134014764	134014764	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccatgggagttgtcgtaGactatacaaaccaagtggaa	13	9	11	8	1	0	1	0	0	0	1	1	3	0	3	2	2	3	2	2	2	6	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:134014764G>T	uc004cag.2	+	10	1213	c.1102G>T	c.(1102-1104)GAC>TAC	p.D368Y	NUP214_uc004cah.2_Missense_Mutation_p.D368Y|NUP214_uc004caf.1_Missense_Mutation_p.D368Y	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	368					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		AGTTGTCGTAGACTATACAAA	0.418			T	DEK|SET|ABL1	AML|T-ALL								10	41					9.31168e-06	9.89201e-06	1	0	T	134014764	T	T	134014764	3	4	130	1	0	0	0	0	1	0	0	0	10816	942	33	2	1140	2	NUP214	9	134014764	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6031836	134014764	7198667	145	23377											
C9orf163	158055	broad.mit.edu	37	chr9	139379468	139379468	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcccagggctcgaccctCtagggtcctccgaaaccctg	7	6	12	16	2	1	0	0	0	1	0	4	3	3	1	5	3	2	1	5	3	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:139379468C>A	uc004chy.2	+	1	1522	c.568C>A	c.(568-570)CTA>ATA	p.L190I	SEC16A_uc004chx.2_5'Flank|SEC16A_uc010nbo.1_5'Flank	NM_152571	NP_689784	Q8N9P6	CI163_HUMAN	hypothetical protein LOC158055	190							protein binding				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.36e-06)|Epithelial(140;5.65e-06)		GCTCGACCCTCTAGGGTCCTC	0.607											OREG0019617	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	17					3.59834e-05	3.8118e-05	1	0	A	139379468	A	A	139379468	3	1	130	1	0	0	0	0	1	0	0	0	2479	912	32	2	570	2	C9orf163	9	139379468	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	5364704	139379468	1833963	146	23378											
TMEM203	94107	broad.mit.edu	37	chr9	140099678	140099678	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcacggacacgatggtggtGaagtaggtgctgagcccgtc	8	7	16	10	4	0	2	0	2	0	0	1	4	0	3	1	4	2	3	1	4	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr9:140099678G>A	uc004clv.2	-	1	413	c.189C>T	c.(187-189)TTC>TTT	p.F63F	NDOR1_uc004clx.2_5'Flank|NDOR1_uc004clw.2_5'Flank|NDOR1_uc011mes.1_5'Flank|NDOR1_uc004cly.2_5'Flank	NM_053045	NP_444273	Q969S6	TM203_HUMAN	transmembrane protein 203	63	Helical; (Potential).					integral to membrane					0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CGATGGTGGTGAAGTAGGTGC	0.617													4	21					0	0	0	0	A	140099678	A	A	140099678	2	1	130	1	0	0	0	0	0	0	0	1	16194	1281	45	2		2	TMEM203	9	140099678	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	720210	140099678	1113753	147	23379											
C10orf18	54906	broad.mit.edu	37	chr10	5789019	5789019	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggactcatcatcagcctCtaccaccttgggaaggcagt	10	9	10	12	0	4	0	3	0	1	0	4	2	4	2	3	3	2	1	3	3	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:5789019C>A	uc001iij.2	+	15	4260	c.3635C>A	c.(3634-3636)TCT>TAT	p.S1212Y	C10orf18_uc001iik.2_Missense_Mutation_p.S56Y	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1212										ovary(1)|central_nervous_system(1)	2						TCATCAGCCTCTACCACCTTG	0.473													8	81					0.00621372	0.00638395	1	0	A	5789019	A	A	5789019	3	1	130	1	0	0	0	0	1	0	0	0	1602	913	32	2	3681	2	C10orf18	10	5789019	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08		5789019	129745728	148	23380											
C10orf18	54906	broad.mit.edu	37	chr10	5789105	5789105	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttagaactaaggaagaatCacaagaatggtccaaacact	18	8	7	8	0	1	3	1	0	0	3	2	4	2	4	1	2	2	0	1	2	8	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:5789105C>T	uc001iij.2	+	15	4346	c.3721C>T	c.(3721-3723)CAC>TAC	p.H1241Y	C10orf18_uc001iik.2_Missense_Mutation_p.H85Y	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1241										ovary(1)|central_nervous_system(1)	2						AAGGAAGAATCACAAGAATGG	0.423													8	61					0	0	0	0	T	5789105	T	T	5789105	3	4	130	1	0	0	0	0	1	0	0	0	1602	826	29	2	3767	2	C10orf18	10	5789105	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	86	5789105	129745642	149	23381											
ABI1	10006	broad.mit.edu	37	chr10	27048143	27048143	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggtcattgtgccatactggGaaccaggagctgagcccggg	8	8	15	10	1	1	1	1	1	0	0	1	3	1	3	3	4	5	1	3	4	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:27048143G>A	uc001isx.2	-	9	1093	c.926C>T	c.(925-927)TCC>TTC	p.S309F	ABI1_uc001ite.2_Missense_Mutation_p.S276F|ABI1_uc010qdh.1_Intron|ABI1_uc010qdi.1_Intron|ABI1_uc001isy.2_Missense_Mutation_p.S282F|ABI1_uc001ita.2_Missense_Mutation_p.S282F|ABI1_uc001isz.2_Missense_Mutation_p.S277F|ABI1_uc001itb.2_Missense_Mutation_p.S326F|ABI1_uc001itc.2_Missense_Mutation_p.S281F|ABI1_uc010qdj.1_Intron|ABI1_uc001itd.2_Missense_Mutation_p.S281F|ABI1_uc010qdk.1_Intron|ABI1_uc010qdg.1_Missense_Mutation_p.S148F	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a	309	Pro-rich.				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						GCCATACTGGGAACCAGGAGC	0.483													14	56					0	0	0	0	A	27048143	A	A	27048143	3	1	130	1	0	0	0	0	1	0	0	0	88	1174	41	2	616	2	ABI1	10	27048143	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	21259038	27048143	108486604	150	23382											
DDX21	9188	broad.mit.edu	37	chr10	70737337	70737337	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcacttcaaacaatcagctGagaagctgatagaggagaag	16	7	11	7	0	3	4	3	2	0	3	3	6	3	4	0	1	3	2	0	1	5	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:70737337G>A	uc001jov.1	+	12	1885	c.1795G>A	c.(1795-1797)GAG>AAG	p.E599K	DDX21_uc001jow.1_Missense_Mutation_p.E531K	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	599						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						ACAATCAGCTGAGAAGCTGAT	0.507													16	117					0	0	0	0	A	70737337	A	A	70737337	3	1	130	1	0	0	0	0	1	0	0	0	4366	1291	45	2	1841	2	DDX21	10	70737337	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	43689194	70737337	64797410	151	23383											
POLR3A	11128	broad.mit.edu	37	chr10	79742546	79742546	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacggagcttggatgtgcaGatggaatatctcactgtctc	10	11	11	9	1	2	1	1	0	2	1	4	4	2	4	0	3	2	2	0	3	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:79742546G>C	uc001jzn.2	-	27	3553	c.3459C>G	c.(3457-3459)ATC>ATG	p.I1153M		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	1153					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			TGGATGTGCAGATGGAATATC	0.433													7	41					0	0	0	0	C	79742546	C	C	79742546	3	2	130	1	0	0	0	0	1	0	0	0	12283	932	33	2	733	2	POLR3A	10	79742546	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	9005209	79742546	55792201	152	23384											
KIF20B	9585	broad.mit.edu	37	chr10	91505671	91505671	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtaggagcagttaaataatCagaaagtggaagaagctata	18	9	11	3	0	1	2	1	0	0	2	1	4	1	4	0	2	2	4	0	2	9	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:91505671C>G	uc001kgs.1	+	23	4123	c.4051C>G	c.(4051-4053)CAG>GAG	p.Q1351E	KIF20B_uc001kgr.1_Missense_Mutation_p.Q1311E|KIF20B_uc001kgt.1_Missense_Mutation_p.Q562E|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1351					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						GTTAAATAATCAGAAAGTGGA	0.264													3	30					0	0	0	0	G	91505671	G	G	91505671	3	3	130	1	0	0	0	0	1	0	0	0	8326	827	29	2	4017	2	KIF20B	10	91505671	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	11763125	91505671	44029076	153	23385											
PKD2L1	9033	broad.mit.edu	37	chr10	102048203	102048203	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgggagagtctcctctcctCtaaggcttcctcttctcttt	5	15	7	14	1	5	1	0	0	5	1	9	2	6	1	3	2	0	1	3	2	1	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:102048203C>G	uc001kqx.1	-	16	2751	c.2368G>C	c.(2368-2370)GAG>CAG	p.E790Q	BLOC1S2_uc001kqv.1_5'Flank|BLOC1S2_uc001kqw.1_5'Flank|PKD2L1_uc009xwm.1_Missense_Mutation_p.E743Q	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	790	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CTCCTCTCCTCTAAGGCTTCC	0.488													24	132					0	0	0	0	G	102048203	G	G	102048203	3	3	130	1	0	0	0	0	1	0	0	0	12022	922	32	2	53	2	PKD2L1	10	102048203	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	10542532	102048203	33486544	154	23386											
DPCD	25911	broad.mit.edu	37	chr10	103360965	103360965	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttgccttctgcagcctatCttcatgcgcaaggacaccaa	10	11	7	13	1	3	0	1	0	2	0	3	1	3	1	3	1	4	2	3	1	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:103360965C>G	uc001ktn.2	+	4	281	c.276C>G	c.(274-276)ATC>ATG	p.I92M	hsa-mir-3158-1|MI0014186_5'Flank	NM_015448	NP_056263	Q9BVM2	DPCD_HUMAN	DPCD protein	92							protein binding			skin(1)	1						TGCAGCCTATCTTCATGCGCA	0.552													10	72					0	0	0	0	G	103360965	G	G	103360965	3	3	130	1	0	0	0	0	1	0	0	0	4733	903	32	2	290	2	DPCD	10	103360965	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1312762	103360965	32173782	155	23387											
LDB1	8861	broad.mit.edu	37	chr10	103871248	103871248	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggaaaggcgttgccgttcGggggctccttcggcgagtac	5	8	18	10	5	0	0	0	0	0	0	3	2	1	1	2	6	2	4	2	6	2	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:103871248G>A	uc009xwz.2	-	2	414	c.71C>T	c.(70-72)CCG>CTG	p.P24L	LDB1_uc001kuk.3_5'UTR|LDB1_uc001kul.3_5'UTR	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	24					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		GTTGCCGTTCGGGGGCTCCTT	0.468													7	34					0	0	0	0	A	103871248	A	A	103871248	3	1	130	1	0	0	0	0	1	0	0	0	8735	1116	39	1	1204	1	LDB1	10	103871248	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	510283	103871248	31663499	156	23388											
AFAP1L2	84632	broad.mit.edu	37	chr10	116057054	116057054	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccctgcctcagccttcttCaggttgtccttcacctccat	4	13	7	17	0	4	0	3	0	1	0	6	0	6	0	6	2	2	1	6	2	0	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:116057054C>G	uc001lbn.2	-	17	2533	c.2232G>C	c.(2230-2232)CTG>CTC	p.L744L	AFAP1L2_uc001lbo.2_Silent_p.L744L|AFAP1L2_uc010qse.1_Silent_p.L797L|AFAP1L2_uc001lbp.2_Silent_p.L772L|AFAP1L2_uc001lbm.2_Silent_p.L183L|AFAP1L2_uc010qsd.1_Silent_p.L310L|AFAP1L2_uc001lbq.1_Silent_p.L266L	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	744	Potential.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		CAGCCTTCTTCAGGTTGTCCT	0.627													6	34					0	0	0	0	G	116057054	G	G	116057054	2	3	130	1	0	0	0	0	0	0	0	1	355	813	29	2		2	AFAP1L2	10	116057054	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	12185806	116057054	19477693	157	23389											
INPP5F	22876	broad.mit.edu	37	chr10	121556365	121556365	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaggagtccacctgtgtaGatgatattcacccacgattt	10	12	8	11	1	2	2	2	1	0	1	3	4	3	3	3	1	0	1	3	1	2	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:121556365G>C	uc001leo.2	+	7	974	c.808G>C	c.(808-810)GAT>CAT	p.D270H		NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	270	SAC.						phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CACCTGTGTAGATGATATTCA	0.468													4	60					0	0	0	0	C	121556365	C	C	121556365	3	2	130	1	0	0	0	0	1	0	0	0	7797	942	33	2	834	2	INPP5F	10	121556365	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	5499311	121556365	13978382	158	23390											
C10orf137	26098	broad.mit.edu	37	chr10	127429586	127429586	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagatacttattgctgcctCtgcaccaatatgctttccga	10	13	6	12	1	1	1	0	0	1	1	2	2	2	1	3	0	5	3	3	0	4	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:127429586C>G	uc001liq.1	+	17	2480	c.2187C>G	c.(2185-2187)CTC>CTG	p.L729L	C10orf137_uc001lin.2_Silent_p.L695L|C10orf137_uc001lio.1_Silent_p.L695L|C10orf137_uc001lip.1_Silent_p.L433L|C10orf137_uc001lir.2_Silent_p.L223L|C10orf137_uc001lis.1_Silent_p.L55L	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	729					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				ATTGCTGCCTCTGCACCAATA	0.363													29	103					0	0	0	0	G	127429586	G	G	127429586	2	3	130	1	0	0	0	0	0	0	0	1	1600	900	32	2		2	C10orf137	10	127429586	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	5873221	127429586	8105161	159	23391											
MGMT	4255	broad.mit.edu	37	chr10	131557595	131557595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagtgggaggagcaatgaGaggcaatcctgtgagttctc	11	8	15	7	0	1	2	0	2	1	1	3	5	2	4	1	3	2	4	1	3	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr10:131557595G>A	uc001lkh.2	+	4	523	c.497G>A	c.(496-498)AGA>AAA	p.R166K		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	135										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		GGAGCAATGAGAGGCAATCCT	0.577								Direct_reversal_of_damage					11	46					0	0	0	0	A	131557595	A	A	131557595	3	1	130	1	0	0	0	0	1	0	0	0	9610	942	33	2	511	2	MGMT	10	131557595	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	4128009	131557595	3977152	160	23392											
PHRF1	57661	broad.mit.edu	37	chr11	609574	609574	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggaaggaagacagcccctCtgcgagtgggagggtacagg	10	4	19	8	1	1	1	0	0	1	1	1	5	1	4	2	6	3	1	2	6	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:609574C>G	uc001lqe.2	+	14	4249	c.4118C>G	c.(4117-4119)TCT>TGT	p.S1373C	PHRF1_uc010qwc.1_Missense_Mutation_p.S1372C|PHRF1_uc010qwd.1_Missense_Mutation_p.S1371C|PHRF1_uc010qwe.1_Missense_Mutation_p.S1369C|PHRF1_uc009ybz.1_Missense_Mutation_p.S1163C|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1373							RNA polymerase binding|zinc ion binding				0						GACAGCCCCTCTGCGAGTGGG	0.682													3	13					0	0	0	0	G	609574	G	G	609574	3	3	130	1	0	0	0	0	1	0	0	0	11916	913	32	2	4165	2	PHRF1	11	609574	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08		609574	134396942	161	23393											
LRDD	55367	broad.mit.edu	37	chr11	799973	799973	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agattcaagggtgccaaggaGaggccagccccccgccgtgg	9	4	15	13	2	1	2	1	0	0	2	1	3	1	2	6	4	2	0	6	4	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:799973G>C	uc001lro.1	-	15	2458	c.2316C>G	c.(2314-2316)CTC>CTG	p.L772L	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Silent_p.L755L|LRDD_uc001lrl.1_Silent_p.L615L|LRDD_uc001lrm.1_Silent_p.L459L|LRDD_uc001lrn.1_Silent_p.L615L|LRDD_uc001lrp.1_Missense_Mutation_p.S456C	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	772					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTGCCAAGGAGAGGCCAGCCC	0.632													9	42					0	0	0	0	C	799973	C	C	799973	2	2	130	1	0	0	0	0	0	0	0	1	8986	929	33	2		2	LRDD	11	799973	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	190399	799973	134206543	162	23394											
KRTAP5-3	387266	broad.mit.edu	37	chr11	1629200	1629200	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaggatgacccacagcctGaggagcagcagcagggctta	12	4	14	11	0	0	2	0	2	0	0	0	4	0	4	2	3	5	5	2	3	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:1629200G>C	uc001ltw.1	-	1	494	c.416C>G	c.(415-417)TCA>TGA	p.S139*		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	139	11 X 4 AA repeats of C-C-X-P.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		CCCACAGCCTGAGGAGCAGCA	0.547													26	156					0	0	0	0	C	1629200	C	C	1629200	4	2	130	1	0	0	0	0	0	1	0	0	8602	1294	45	2	304	2	KRTAP5-3	11	1629200	Nonsense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	829227	1629200	133377316	163	23395											
TNNT3	7140	broad.mit.edu	37	chr11	1956113	1956113	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagctggagattgacaagttCgagtttggggagaagctgaa	12	9	15	5	1	0	4	0	2	0	2	1	7	0	4	0	3	2	4	0	3	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:1956113C>G	uc001luu.3	+	14	857	c.645C>G	c.(643-645)TTC>TTG	p.F215L	TNNT3_uc001lun.2_Missense_Mutation_p.F111L|TNNT3_uc001luw.3_Missense_Mutation_p.F207L|TNNT3_uc001luo.3_Missense_Mutation_p.F207L|TNNT3_uc001lup.3_Missense_Mutation_p.F213L|TNNT3_uc001luq.3_Missense_Mutation_p.F207L|TNNT3_uc001lur.2_Missense_Mutation_p.F207L|TNNT3_uc010qxf.1_Missense_Mutation_p.F213L|TNNT3_uc010qxg.1_Missense_Mutation_p.F147L	NM_006757	NP_006748	P45378	TNNT3_HUMAN	troponin T3, skeletal, fast isoform 1	226					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		TTGACAAGTTCGAGTTTGGGG	0.597													32	135					0	0	0	0	G	1956113	G	G	1956113	3	3	130	1	0	0	0	0	1	0	0	0	16398	883	31	3	736	3	TNNT3	11	1956113	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	326913	1956113	133050403	164	23396											
OR56A5	390084	broad.mit.edu	37	chr11	5988969	5988969	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaggactgtggtgaagaaGaggatgaggatgaagtggga	14	6	19	2	0	0	5	0	3	0	2	0	9	0	9	0	5	1	1	0	5	3	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:5988969G>C	uc010qzu.1	-	1	756	c.756C>G	c.(754-756)CTC>CTG	p.L252L		NM_001146033	NP_001139505	P0C7T3	O56A5_HUMAN	olfactory receptor, family 56, subfamily A,	252	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	olfactory receptor activity				0						TGGTGAAGAAGAGGATGAGGA	0.478													5	20					0	0	0	0	C	5988969	C	C	5988969	2	2	130	1	0	0	0	0	0	0	0	1	11190	929	33	2		2	OR56A5	11	5988969	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	4032856	5988969	129017547	165	23397											
OR6A2	8590	broad.mit.edu	37	chr11	6816674	6816674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctgtccatgatcctgtttgGatccaacaaagccagcaagc	11	9	9	12	0	0	1	0	1	0	0	3	2	3	2	4	1	4	3	4	1	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:6816674G>A	uc001mes.1	-	1	466	c.266C>T	c.(265-267)TCC>TTC	p.S89F		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATCCTGTTTGGATCCAACAAA	0.458													12	62					0	0	0	0	A	6816674	A	A	6816674	3	1	130	1	0	0	0	0	1	0	0	0	11240	1174	41	2	721	2	OR6A2	11	6816674	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	827705	6816674	128189842	166	23398											
HIPK3	10114	broad.mit.edu	37	chr11	33363124	33363124	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcaggcattgaccacatctGctcattcagttgtgcaccat	9	13	7	12	0	4	1	3	1	1	0	4	1	4	1	2	1	2	4	2	1	0	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:33363124G>A	uc001mul.1	+	8	2059	c.1789G>A	c.(1789-1791)GCT>ACT	p.A597T	HIPK3_uc001mum.1_Missense_Mutation_p.A597T|HIPK3_uc009yjv.1_Missense_Mutation_p.A597T	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	597					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						GACCACATCTGCTCATTCAGT	0.413													39	318					0	0	0	0	A	33363124	A	A	33363124	3	1	130	1	0	0	0	0	1	0	0	0	7157	1319	46	4	1815	4	HIPK3	11	33363124	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	26546450	33363124	101643392	167	23399											
PDHX	8050	broad.mit.edu	37	chr11	34982054	34982054	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccactggccctcgggggatAttcactaaagagtatgtgtt	9	11	12	9	1	1	1	1	0	0	1	2	2	1	2	2	3	0	2	2	3	4	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:34982054A>G	uc001mvt.2	+	5	1156	c.630A>G	c.(628-630)ATA>ATG	p.I210M	PDHX_uc010rep.1_Missense_Mutation_p.I195M|PDHX_uc010req.1_Intron	NM_003477	NP_003468	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	210	Interaction with DLD.			I->A: Strongly decreased DLD binding.	pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			kidney(1)	1	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			CTCGGGGGATATTCACTAAAG	0.378													8	125					0	0	0	0	G	34982054	G	G	34982054	3	3	130	1	0	0	0	0	1	0	0	0	11721	439	16	5	767	5	PDHX	11	34982054	Missense_Mutation	SNP	A	TCGA-CR-6484-01A-11D-1870-08	1618930	34982054	100024462	168	23400											
LDLRAD3	143458	broad.mit.edu	37	chr11	36250750	36250750	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccaccgccctactcttctGacacggaatctctgaaccaa	10	9	5	17	2	3	2	0	2	3	0	5	3	4	3	4	1	2	0	4	1	4	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:36250750G>C	uc001mwk.1	+	6	878	c.841G>C	c.(841-843)GAC>CAC	p.D281H	LDLRAD3_uc010rey.1_Missense_Mutation_p.D232H|LDLRAD3_uc010rez.1_Missense_Mutation_p.D160H|LDLRAD3_uc010rfa.1_RNA	NM_174902	NP_777562	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain	281	Cytoplasmic (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				CTACTCTTCTGACACGGAATC	0.627													24	858					0	0	0	0	C	36250750	C	C	36250750	3	2	130	1	0	0	0	0	1	0	0	0	8747	1290	45	2	863	2	LDLRAD3	11	36250750	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1268696	36250750	98755766	169	23401											
COMMD9	29099	broad.mit.edu	37	chr11	36300091	36300091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggaaattttctggaaagaGagccagaattgcctcggcag	12	9	13	7	1	1	2	0	0	1	2	2	5	1	4	2	3	2	1	2	3	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:36300091G>A	uc001mwn.3	-	3	290	c.253C>T	c.(253-255)CTC>TTC	p.L85F	COMMD9_uc009ykj.2_Missense_Mutation_p.L43F|COMMD9_uc010rfb.1_Missense_Mutation_p.L85F	NM_014186	NP_054905	Q9P000	COMD9_HUMAN	COMM domain containing 9 isoform 1	85										ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				TCTGGAAAGAGAGCCAGAATT	0.483													11	350					0	0	0	0	A	36300091	A	A	36300091	3	1	130	1	0	0	0	0	1	0	0	0	3738	942	33	2	359	2	COMMD9	11	36300091	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	49341	36300091	98706425	170	23402											
KIAA0652	9776	broad.mit.edu	37	chr11	46687010	46687010	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtacccaggctgaccaggaGagactggcaacctgcacccc	10	4	12	15	0	0	2	0	1	0	1	0	4	0	3	5	4	3	4	5	4	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:46687010G>C	uc009yld.2	+	13	1662	c.978G>C	c.(976-978)GAG>GAC	p.E326D	KIAA0652_uc001nda.2_Missense_Mutation_p.E359D|KIAA0652_uc001ndb.2_Missense_Mutation_p.E326D|KIAA0652_uc001ncz.2_Missense_Mutation_p.E289D|KIAA0652_uc001ndc.2_Missense_Mutation_p.E289D|KIAA0652_uc010rgv.1_Missense_Mutation_p.E210D	NM_001142673	NP_001136145	O75143	ATG13_HUMAN	autophagy-related protein 13 isoform 1	326					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding				0				GBM - Glioblastoma multiforme(35;0.226)		CTGACCAGGAGAGACTGGCAA	0.562													9	64					0	0	0	0	C	46687010	C	C	46687010	3	2	130	1	0	0	0	0	1	0	0	0	8227	933	33	2	1020	2	KIAA0652	11	46687010	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	10386919	46687010	88319506	171	23403											
ARFGAP2	84364	broad.mit.edu	37	chr11	47189775	47189775	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctgctcaatcacctgcatCtcagacagcacggagtggga	10	8	10	13	1	3	1	3	0	1	1	5	3	4	3	2	2	3	3	2	2	1	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:47189775C>G	uc001ndt.2	-	11	984	c.969G>C	c.(967-969)GAG>GAC	p.E323D	ARFGAP2_uc010rha.1_Missense_Mutation_p.E54D|ARFGAP2_uc010rhb.1_Missense_Mutation_p.E295D|ARFGAP2_uc001ndu.2_Missense_Mutation_p.E187D|ARFGAP2_uc010rhc.1_Missense_Mutation_p.E54D	NM_032389	NP_115765	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating	323	Required for interaction with coatomer.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			ovary(1)	1						TCACCTGCATCTCAGACAGCA	0.552													8	55					0	0	0	0	G	47189775	G	G	47189775	3	3	130	1	0	0	0	0	1	0	0	0	850	912	32	2	620	2	ARFGAP2	11	47189775	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	502765	47189775	87816741	172	23404											
MADD	8567	broad.mit.edu	37	chr11	47295502	47295502	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttctgtcctcggttacttGactatctagtgatcgtaggg	7	15	11	8	2	2	2	0	2	2	0	5	2	3	2	1	2	1	3	1	2	4	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:47295502G>C	uc001ner.1	+	2	228	c.37G>C	c.(37-39)GAC>CAC	p.D13H	MADD_uc001neq.2_Missense_Mutation_p.D13H|MADD_uc001nev.1_Missense_Mutation_p.D13H|MADD_uc001nes.1_Missense_Mutation_p.D13H|MADD_uc001net.1_Missense_Mutation_p.D13H|MADD_uc009yln.1_Missense_Mutation_p.D13H|MADD_uc001neu.1_Missense_Mutation_p.D13H|MADD_uc001nex.2_Missense_Mutation_p.D13H|MADD_uc001nez.2_Missense_Mutation_p.D13H|MADD_uc001new.2_Missense_Mutation_p.D13H	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	13					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		TCGGTTACTTGACTATCTAGT	0.443													8	37					0	0	0	0	C	47295502	C	C	47295502	3	2	130	1	0	0	0	0	1	0	0	0	9203	1290	45	2	39	2	MADD	11	47295502	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	105727	47295502	87711014	173	23405											
OR8K5	219453	broad.mit.edu	37	chr11	55927105	55927105	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctttttcctgccctctgcaGaatgcatttgacatatagct	8	15	6	12	0	1	2	0	1	1	1	2	2	2	2	3	0	4	3	3	0	3	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:55927105G>A	uc010rja.1	-	1	689	c.689C>T	c.(688-690)TCT>TTT	p.S230F		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				GCCCTCTGCAGAATGCATTTG	0.398													8	40					0	0	0	0	A	55927105	A	A	55927105	3	1	130	1	0	0	0	0	1	0	0	0	11299	942	33	2	237	2	OR8K5	11	55927105	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	8631603	55927105	79079411	174	23406											
LRRC55	219527	broad.mit.edu	37	chr11	56954823	56954823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccacctgaccctgaccctgGatgattacctattcattgcg	8	11	8	14	1	1	3	1	3	0	0	1	4	1	4	5	1	2	0	5	1	2	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:56954823G>A	uc001njl.1	+	2	1042	c.895G>A	c.(895-897)GAT>AAT	p.D299N	LRRC55_uc001njm.1_5'Flank	NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	269						integral to membrane					0						CCTGACCCTGGATGATTACCT	0.607													9	77					0	0	0	0	A	56954823	A	A	56954823	3	1	130	1	0	0	0	0	1	0	0	0	9061	1174	41	2	901	2	LRRC55	11	56954823	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1027718	56954823	78051693	175	23407											
FAM111A	63901	broad.mit.edu	37	chr11	58920371	58920371	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attggtcaatgtgtaagggtGacatttggttatgaagagct	11	14	13	3	0	1	3	1	2	0	1	1	3	1	3	0	3	1	3	0	3	4	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:58920371G>A	uc010rkp.1	+	5	1457	c.1230G>A	c.(1228-1230)GTG>GTA	p.V410V	FAM111A_uc010rkq.1_Silent_p.V410V|FAM111A_uc010rkr.1_Silent_p.V410V|FAM111A_uc001nno.2_Silent_p.V410V|FAM111A_uc001nnp.2_Silent_p.V410V|FAM111A_uc001nnq.2_Silent_p.V410V	NM_001142521	NP_001135993	Q96PZ2	F111A_HUMAN	hypothetical protein LOC63901	410					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_epithelial(135;0.139)				GTGTAAGGGTGACATTTGGTT	0.383													14	80					0	0	0	0	A	58920371	A	A	58920371	2	1	130	1	0	0	0	0	0	0	0	1	5427	1277	45	2		2	FAM111A	11	58920371	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1965548	58920371	76086145	176	23408											
GAL3ST3	89792	broad.mit.edu	37	chr11	65810464	65810464	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaggcgcgagctggcggcGcgcgcgttgagcttggcgta	4	6	19	12	8	0	1	0	1	0	0	0	2	0	1	1	4	2	4	1	4	1	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:65810464G>A	uc001ogv.2	-	2	970	c.810C>T	c.(808-810)CGC>CGT	p.R270R	GAL3ST3_uc001ogw.2_Silent_p.R270R	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	270	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1						AGCTGGCGGCGCGCGCGTTGA	0.577													4	17					0	0	0	0	A	65810464	A	A	65810464	2	1	130	1	0	0	0	0	0	0	0	1	6234	1074	38	1		1	GAL3ST3	11	65810464	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6890093	65810464	69196052	177	23409											
RIN1	9610	broad.mit.edu	37	chr11	66102285	66102285	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctgggctcccccgggaccCtggcaccccctcctcctcgg	2	6	11	22	3	0	0	0	0	0	0	4	1	3	1	7	4	0	3	7	4	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:66102285C>A	uc001ohn.1	-	6	1112	c.985G>T	c.(985-987)GGG>TGG	p.G329W	RIN1_uc010roy.1_Missense_Mutation_p.G22W|RIN1_uc009yrd.1_Missense_Mutation_p.G22W|RIN1_uc010roz.1_Missense_Mutation_p.G224W|RIN1_uc010rpa.1_Missense_Mutation_p.G224W	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	329	Ras and 14-3-3 protein binding region.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						CCCCGGGACCCTGGCACCCCC	0.721													2	2					0.0016	0.00165289	1	0	A	66102285	A	A	66102285	3	1	130	1	0	0	0	0	1	0	0	0	13436	681	24	4	1386	4	RIN1	11	66102285	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	291821	66102285	68904231	178	23410											
CARNS1	57571	broad.mit.edu	37	chr11	67191490	67191490	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaatggccctacgaggctGcctggcttcactgagacggc	8	7	13	13	2	1	1	1	1	0	1	1	4	1	1	2	4	2	2	2	4	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:67191490G>C	uc009yrp.2	+	9	2354	c.1902G>C	c.(1900-1902)CTG>CTC	p.L634L	PPP1CA_uc001okx.1_5'Flank|CARNS1_uc001olc.3_Silent_p.L773L	NM_020811	NP_065862	A5YM72	CRNS1_HUMAN	ATP-grasp domain containing 1	634	ATP-grasp.				carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding				0						CTACGAGGCTGCCTGGCTTCA	0.642													5	20					0	0	0	0	C	67191490	C	C	67191490	2	2	130	1	0	0	0	0	0	0	0	1	2668	1306	46	4		4	CARNS1	11	67191490	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1089205	67191490	67815026	179	23411											
PPFIA1	8500	broad.mit.edu	37	chr11	70218613	70218613	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtgtggaattatgtgcctGagaaggttaaattatgaccg	12	12	12	5	1	0	2	0	2	0	1	0	4	0	3	2	2	1	1	2	2	6	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:70218613G>C	uc001opo.2	+	23	3270	c.3072G>C	c.(3070-3072)CTG>CTC	p.L1024L	PPFIA1_uc001opn.1_Silent_p.L1024L|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opr.2_Silent_p.L163L|PPFIA1_uc001ops.2_Silent_p.L63L	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	1024	Potential.|SAM 2.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TTATGTGCCTGAGAAGGTTAA	0.328													7	45					0	0	0	0	C	70218613	C	C	70218613	2	2	130	1	0	0	0	0	0	0	0	1	12364	1277	45	2		2	PPFIA1	11	70218613	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	3027123	70218613	64787903	180	23412											
ARHGEF17	9828	broad.mit.edu	37	chr11	73074301	73074301	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggcagagaccaccagctcaGaggaggagcaggagccaggc	12	1	16	12	1	1	2	1	0	0	2	1	6	1	5	3	5	3	3	3	5	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:73074301G>C	uc001otu.2	+	15	5068	c.5047G>C	c.(5047-5049)GAG>CAG	p.E1683Q		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1683					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CACCAGCTCAGAGGAGGAGCA	0.637													3	14					0	0	0	0	C	73074301	C	C	73074301	3	2	130	1	0	0	0	0	1	0	0	0	900	943	33	2	5105	2	ARHGEF17	11	73074301	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2855688	73074301	61932215	181	23413											
ARHGEF17	9828	broad.mit.edu	37	chr11	73074384	73074384	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcaccagcccaatggatggGagagcccttcgccgctccag	8	5	13	15	2	0	1	0	0	0	1	2	3	1	2	5	3	2	2	5	3	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:73074384G>C	uc001otu.2	+	15	5151	c.5130G>C	c.(5128-5130)GGG>GGC	p.G1710G		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1710					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CAATGGATGGGAGAGCCCTTC	0.667													3	14					0	0	0	0	C	73074384	C	C	73074384	2	2	130	1	0	0	0	0	0	0	0	1	900	1161	41	2		2	ARHGEF17	11	73074384	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	83	73074384	61932132	182	23414											
FDX1	2230	broad.mit.edu	37	chr11	110327657	110327657	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtcaggtgcatgtgagggaaCcctggcttgttcaacctgtc	7	11	13	10	0	2	1	2	1	0	0	3	2	2	2	2	3	3	3	2	3	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:110327657C>G	uc001pkx.2	+	3	577	c.326C>G	c.(325-327)ACC>AGC	p.T109S		NM_004109	NP_004100	P10109	ADX_HUMAN	ferredoxin 1 precursor	109	2Fe-2S ferredoxin-type.				electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|iron ion binding				0		all_cancers(61;1.59e-12)|all_epithelial(67;8.38e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;5.27e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0384)|Colorectal(284;0.228)	Mitotane(DB00648)	TGTGAGGGAACCCTGGCTTGT	0.418													27	144					0	0	0	0	G	110327657	G	G	110327657	3	3	130	1	0	0	0	0	1	0	0	0	5836	507	18	4	336	4	FDX1	11	110327657	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	37253273	110327657	24678859	183	23415											
DIXDC1	85458	broad.mit.edu	37	chr11	111844775	111844775	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatggaaacctgaagtctatCatgaggctggtccttgcctt	9	12	11	9	0	2	2	1	2	1	0	3	4	3	3	3	3	2	1	3	3	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:111844775C>T	uc001pml.2	+	4	642	c.345C>T	c.(343-345)ATC>ATT	p.I115I	DIXDC1_uc001pmj.2_Silent_p.I108I|DIXDC1_uc001pmk.2_Silent_p.I115I	NM_001037954	NP_001033043	Q155Q3	DIXC1_HUMAN	DIX domain containing 1 isoform a	115	CH.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			ovary(1)	1		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		TGAAGTCTATCATGAGGCTGG	0.512													8	37					0	0	0	0	T	111844775	T	T	111844775	2	4	130	1	0	0	0	0	0	0	0	1	4563	816	29	2		2	DIXDC1	11	111844775	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1517118	111844775	23161741	184	23416											
DIXDC1	85458	broad.mit.edu	37	chr11	111889689	111889689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttctctagattttccatGatgatgatgccatccctgga	8	17	7	9	0	1	4	0	3	1	1	4	5	3	5	3	1	1	0	3	1	1	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:111889689G>A	uc001pml.2	+	21	2278	c.1981G>A	c.(1981-1983)GAT>AAT	p.D661N	DIXDC1_uc001pmm.2_Missense_Mutation_p.D450N|DIXDC1_uc001pmn.2_Missense_Mutation_p.D367N|DIXDC1_uc010rwq.1_Missense_Mutation_p.D326N	NM_001037954	NP_001033043	Q155Q3	DIXC1_HUMAN	DIX domain containing 1 isoform a	661	DIX.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			ovary(1)	1		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		GATTTTCCATGATGATGATGC	0.388													10	77					0	0	0	0	A	111889689	A	A	111889689	3	1	130	1	0	0	0	0	1	0	0	0	4563	1290	45	2	2085	2	DIXDC1	11	111889689	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	44914	111889689	23116827	185	23417											
BSX	390259	broad.mit.edu	37	chr11	122848536	122848536	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgtctggtgctttgggttCgtcttggcttttccgcagtt	1	17	12	11	3	2	0	0	0	2	0	4	0	3	0	2	3	1	5	2	3	0	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:122848536C>T	uc010rzs.1	-	3	523	c.523G>A	c.(523-525)GAA>AAA	p.E175K		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	175											0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		GCTTTGGGTTCGTCTTGGCTT	0.592													14	47					0	0	0	0	T	122848536	T	T	122848536	3	4	130	1	0	0	0	0	1	0	0	0	1540	893	31	1	181	1	BSX	11	122848536	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	10958847	122848536	12157980	186	23418											
KCNJ5	3762	broad.mit.edu	37	chr11	128781747	128781747	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtcaagatcagccagccCaagaagagagcggagaccct	13	6	11	11	1	2	4	2	0	0	4	2	6	2	4	3	1	3	0	3	1	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr11:128781747C>G	uc001qet.2	+	2	893	c.579C>G	c.(577-579)CCC>CCG	p.P193P	KCNJ5_uc009zck.2_Silent_p.P193P|KCNJ5_uc001qew.2_Silent_p.P193P	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	193	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	TCAGCCAGCCCAAGAAGAGAG	0.562													14	97					0	0	0	0	G	128781747	G	G	128781747	2	3	130	1	0	0	0	0	0	0	0	1	8093	581	21	4		4	KCNJ5	11	128781747	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	5933211	128781747	6224769	187	23419											
KCNA6	3742	broad.mit.edu	37	chr12	4919508	4919508	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgccatcctctactactacCagtctgggggccgcctgcgg	6	8	11	16	3	2	0	0	0	2	0	3	0	3	0	5	3	4	0	5	3	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:4919508C>T	uc001qng.2	+	1	1167	c.301C>T	c.(301-303)CAG>TAG	p.Q101*		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	101						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CTACTACTACCAGTCTGGGGG	0.657										HNSCC(72;0.22)			17	69					0	0	0	0	T	4919508	T	T	4919508	4	4	130	1	0	0	0	0	0	1	0	0	8046	595	21	4	303	4	KCNA6	12	4919508	Nonsense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08		4919508	128932387	188	23420											
SPSB2	84727	broad.mit.edu	37	chr12	6980429	6980429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctggccgagccgggtatccCccaggttgtggcgcacacac	6	6	13	16	3	0	0	0	0	0	0	1	1	1	0	5	4	1	3	5	4	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:6980429C>T	uc001qrl.2	-	3	875	c.719G>A	c.(718-720)GGG>GAG	p.G240E	SPSB2_uc001qrm.2_Missense_Mutation_p.G240E|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	240	SOCS box.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1						CCGGGTATCCCCCAGGTTGTG	0.627													6	25					0	0	0	0	T	6980429	T	T	6980429	3	4	130	1	0	0	0	0	1	0	0	0	15179	623	22	4	76	4	SPSB2	12	6980429	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	2060921	6980429	126871466	189	23421											
LRP6	4040	broad.mit.edu	37	chr12	12274061	12274061	+	Nonstop_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggaggagggcccctcctCaggaggagtctgtacaggga	10	5	17	9	0	2	1	1	0	1	1	3	6	3	6	3	6	1	1	3	6	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:12274061C>G	uc001rah.3	-	23	4983	c.4841G>C	c.(4840-4842)TGA>TCA	p.*1614S	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Nonstop_Mutation_p.*1569S	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1614					cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				GGCCCCTCCTCAGGAGGAGTC	0.517													5	24					0	0	0	0	G	12274061	G	G	12274061	4	3	130	1	0	0	0	0	0	0	0	0	9012	837	29	2	4	2	LRP6	12	12274061	Nonstop_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	5293632	12274061	121577834	190	23422											
ATF7IP	55729	broad.mit.edu	37	chr12	14589102	14589102	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaatgtacagtctaaacgtCgtcgatatatggaagaagaa	17	9	9	6	3	1	2	0	0	1	2	3	4	1	3	0	1	2	1	0	1	9	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:14589102C>T	uc001rbw.2	+	4	1866	c.1708C>T	c.(1708-1710)CGT>TGT	p.R570C	ATF7IP_uc010shs.1_Missense_Mutation_p.R569C|ATF7IP_uc001rbu.2_Missense_Mutation_p.R570C|ATF7IP_uc001rbv.1_Missense_Mutation_p.R569C|ATF7IP_uc001rbx.2_Missense_Mutation_p.R569C|ATF7IP_uc010sht.1_Missense_Mutation_p.R570C|ATF7IP_uc001rby.3_Missense_Mutation_p.R570C|ATF7IP_uc001rca.2_Missense_Mutation_p.R570C	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	570	Interaction with SETDB1.|Glu-rich.|Nuclear localization signal (By similarity).				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						GTCTAAACGTCGTCGATATAT	0.353													24	67					0	0	0	0	T	14589102	T	T	14589102	3	4	130	1	0	0	0	0	1	0	0	0	1089	884	31	1	1718	1	ATF7IP	12	14589102	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	2315041	14589102	119262793	191	23423											
WNT1	7471	broad.mit.edu	37	chr12	49373291	49373291	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctccacgaacctgcttacaGactccaagagtctgcaactg	11	8	7	15	1	1	2	0	0	1	2	3	3	3	2	4	0	5	2	4	0	4	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:49373291G>A	uc001rsu.2	+	2	343	c.145G>A	c.(145-147)GAC>AAC	p.D49N		NM_005430	NP_005421	P04628	WNT1_HUMAN	wingless-type MMTV integration site family,	49					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			kidney(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.244)		CCTGCTTACAGACTCCAAGAG	0.557													19	101					0	0	0	0	A	49373291	A	A	49373291	3	1	130	1	0	0	0	0	1	0	0	0	17449	942	33	2	151	2	WNT1	12	49373291	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	34784189	49373291	84478604	192	23424											
MLL2	8085	broad.mit.edu	37	chr12	49436420	49436420	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggagggcagattgcccaaagGgagtccacctacaagacgga	13	4	14	10	1	0	2	0	0	0	2	1	5	1	5	3	4	2	1	3	4	3	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:49436420G>T	uc001rta.3	-	27	5791	c.5791C>A	c.(5791-5793)CCT>ACT	p.P1931T		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1931					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTGCCCAAAGGGAGTCCACCT	0.552			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			21	38					4.96729e-08	5.35268e-08	1	0	T	49436420	T	T	49436420	3	4	130	1	0	0	0	0	1	0	0	0	9674	1232	43	4	10934	4	MLL2	12	49436420	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	63129	49436420	84415475	193	23425											
RHEBL1	121268	broad.mit.edu	37	chr12	49462888	49462888	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgatgtgccaaagatgtcttCcctgtggggagcagtgtgac	8	11	14	8	0	1	3	0	2	1	1	2	4	2	4	2	2	2	1	2	2	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:49462888C>T	uc001rtc.1	-	2	261	c.54G>A	c.(52-54)GGG>GGA	p.G18G	RHEBL1_uc001rtd.1_Silent_p.G14G|RHEBL1_uc009zlc.1_RNA	NM_144593	NP_653194	Q8TAI7	REBL1_HUMAN	Ras homolog enriched in brain like 1 precursor	18	GTP (By similarity).				positive regulation of NF-kappaB transcription factor activity|small GTPase mediated signal transduction|TOR signaling cascade	cytoplasm|plasma membrane	GTP binding|GTPase activity|protein binding			lung(1)|breast(1)	2						AAGATGTCTTCCCTGTGGGGA	0.502													26	69					0	0	0	0	T	49462888	T	T	49462888	2	4	130	1	0	0	0	0	0	0	0	1	13394	869	30	2		2	RHEBL1	12	49462888	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	26468	49462888	84389007	194	23426											
KCNH3	23416	broad.mit.edu	37	chr12	49943272	49943272	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtgacggccatcatccagcGcatgtacgcccgccgctttc	6	8	10	17	6	1	1	1	1	0	0	3	1	2	1	4	1	2	3	4	1	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:49943272G>A	uc001ruh.1	+	9	1777	c.1517G>A	c.(1516-1518)CGC>CAC	p.R506H	KCNH3_uc010smj.1_Missense_Mutation_p.R446H	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	506	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						ATCATCCAGCGCATGTACGCC	0.667													10	49					0	0	0	0	A	49943272	A	A	49943272	3	1	130	1	0	0	0	0	1	0	0	0	8072	1087	38	1	1551	1	KCNH3	12	49943272	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	480384	49943272	83908623	195	23427											
DIP2B	57609	broad.mit.edu	37	chr12	51138607	51138607	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagttagaccccatctacgtGgcttataacatgtaaccagc	12	10	7	12	1	1	1	0	0	1	1	1	1	1	1	3	1	4	3	3	1	5	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:51138607G>A	uc001rwv.2	+	38	4872	c.4716G>A	c.(4714-4716)GTG>GTA	p.V1572V	DIP2B_uc009zlt.2_Silent_p.V1002V	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1572						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						CCATCTACGTGGCTTATAACA	0.517													20	62					0	0	0	0	A	51138607	A	A	51138607	2	1	130	1	0	0	0	0	0	0	0	1	4550	1335	47	4		4	DIP2B	12	51138607	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1195335	51138607	82713288	196	23428											
NR4A1	3164	broad.mit.edu	37	chr12	52448880	52448880	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtgacctcaaccaaggcccgGagcggggccccaggtggaag	9	3	16	13	2	1	1	1	1	0	0	1	3	1	3	5	6	2	0	5	6	3	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:52448880G>C	uc001rzs.2	+	3	1082	c.768G>C	c.(766-768)CGG>CGC	p.R256R	NR4A1_uc010sno.1_Silent_p.R269R|NR4A1_uc001rzr.2_Silent_p.R256R|NR4A1_uc009zmb.1_Silent_p.R256R|NR4A1_uc001rzt.2_Silent_p.R256R|NR4A1_uc009zmc.2_5'Flank	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	256					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CCAAGGCCCGGAGCGGGGCCC	0.612													13	117					0	0	0	0	C	52448880	C	C	52448880	2	2	130	1	0	0	0	0	0	0	0	1	10686	1161	41	2		2	NR4A1	12	52448880	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1310273	52448880	81403015	197	23429											
AAAS	8086	broad.mit.edu	37	chr12	53709522	53709522	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatacttaccctcttcttctGagtttgcaatttcatttagc	9	18	4	10	0	4	1	1	1	3	0	4	1	4	1	1	0	4	2	1	0	5	8			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:53709522G>C	uc001scr.3	-	3	459	c.296C>G	c.(295-297)TCA>TGA	p.S99*	AAAS_uc001scs.3_Nonsense_Mutation_p.S99*	NM_015665	NP_056480	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency,	99					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				ovary(1)	1						CTCTTCTTCTGAGTTTGCAAT	0.483													9	16					0	0	0	0	C	53709522	C	C	53709522	4	2	130	1	0	0	0	0	0	1	0	0	8	1294	45	2	1400	2	AAAS	12	53709522	Nonsense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1260642	53709522	80142373	198	23430											
MAP3K12	7786	broad.mit.edu	37	chr12	53876597	53876597	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cggaggtggtgagccaggatCcccagctccgcctgtggccc	5	6	15	15	2	0	1	0	1	0	0	2	3	2	3	6	5	2	1	6	5	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:53876597C>T	uc001sdm.1	-	12	1989	c.1891G>A	c.(1891-1893)GAT>AAT	p.D631N	MAP3K12_uc001sdn.1_Missense_Mutation_p.D664N	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	631					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						GAGCCAGGATCCCCAGCTCCG	0.667													16	41					0	0	0	0	T	53876597	T	T	53876597	3	4	130	1	0	0	0	0	1	0	0	0	9299	855	30	2	704	2	MAP3K12	12	53876597	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	167075	53876597	79975298	199	23431											
MYL6B	140465	broad.mit.edu	37	chr12	56547847	56547847	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggcccctcagaaaacccagGagcctccagtcgatctctcc	10	6	8	17	1	2	1	1	0	1	1	6	3	4	2	6	2	2	0	6	2	2	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:56547847G>A	uc001sjs.2	+	2	272	c.145G>A	c.(145-147)GAG>AAG	p.E49K	MYL6B_uc009zoo.2_Missense_Mutation_p.E49K|MYL6B_uc001sjt.2_Missense_Mutation_p.E49K|MYL6B_uc001sju.1_Missense_Mutation_p.E49K	NM_002475	NP_002466	P14649	MYL6B_HUMAN	smooth muscle and non-muscle myosin alkali light	49					muscle filament sliding|skeletal muscle tissue development	cytosol|muscle myosin complex|unconventional myosin complex	calcium ion binding|motor activity|protein binding|structural constituent of muscle				0			OV - Ovarian serous cystadenocarcinoma(18;0.0979)			GAAAACCCAGGAGCCTCCAGT	0.572													3	28					0	0	0	0	A	56547847	A	A	56547847	3	1	130	1	0	0	0	0	1	0	0	0	10105	1175	41	2	147	2	MYL6B	12	56547847	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2671250	56547847	77304048	200	23432			1	32		3	3	1129	G		6.823607e-05
MYL6B	140465	broad.mit.edu	37	chr12	56548600	56548600	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcttttttcttccacagatcGagtttaacaaggaccagctg	10	13	8	10	1	1	1	0	0	1	1	3	3	2	2	2	1	2	3	2	1	2	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:56548600G>A	uc001sjs.2	+	3	305	c.178G>A	c.(178-180)GAG>AAG	p.E60K	MYL6B_uc009zoo.2_Missense_Mutation_p.E60K|MYL6B_uc001sjt.2_Missense_Mutation_p.E60K|MYL6B_uc001sju.1_Missense_Mutation_p.E60K	NM_002475	NP_002466	P14649	MYL6B_HUMAN	smooth muscle and non-muscle myosin alkali light	60					muscle filament sliding|skeletal muscle tissue development	cytosol|muscle myosin complex|unconventional myosin complex	calcium ion binding|motor activity|protein binding|structural constituent of muscle				0			OV - Ovarian serous cystadenocarcinoma(18;0.0979)			TCCACAGATCGAGTTTAACAA	0.532													29	198					0	0	0	0	A	56548600	A	A	56548600	3	1	130	1	0	0	0	0	1	0	0	0	10105	1059	37	1	184	1	MYL6B	12	56548600	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	753	56548600	77303295	201	23433			1	32		3	3	1129	G		6.823607e-05
MYL6B	140465	broad.mit.edu	37	chr12	56548975	56548975	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtcctggggaaccccaaGagtgatggtgaggggaccct	10	6	16	9	0	0	3	0	2	0	1	1	5	1	5	4	6	1	0	4	6	3	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:56548975G>A	uc001sjs.2	+	4	466	c.339G>A	c.(337-339)AAG>AAA	p.K113K	MYL6B_uc009zoo.2_Silent_p.K113K|MYL6B_uc001sjt.2_Silent_p.K113K|MYL6B_uc001sju.1_Silent_p.K113K	NM_002475	NP_002466	P14649	MYL6B_HUMAN	smooth muscle and non-muscle myosin alkali light	113					muscle filament sliding|skeletal muscle tissue development	cytosol|muscle myosin complex|unconventional myosin complex	calcium ion binding|motor activity|protein binding|structural constituent of muscle				0			OV - Ovarian serous cystadenocarcinoma(18;0.0979)			GGAACCCCAAGAGTGATGGTG	0.522													23	116					0	0	0	0	A	56548975	A	A	56548975	2	1	130	1	0	0	0	0	0	0	0	1	10105	933	33	2		2	MYL6B	12	56548975	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	375	56548975	77302920	202	23434			1	32		3	3	1129	G		6.823607e-05
TIMELESS	8914	broad.mit.edu	37	chr12	56818549	56818549	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaggcagggttcttaccgaGcagacctcaggagagtcagg	10	6	15	10	1	3	2	2	0	1	2	3	4	3	2	2	4	2	4	2	4	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:56818549G>A	uc001slf.2	-	15	2033	c.1865C>T	c.(1864-1866)GCT>GTT	p.A622V		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	622					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						TTCTTACCGAGCAGACCTCAG	0.587													5	85					0	0	0	0	A	56818549	A	A	56818549	3	1	130	1	0	0	0	0	1	0	0	0	15970	971	34	4	1821	4	TIMELESS	12	56818549	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	269574	56818549	77033346	203	23435											
TSPAN31	6302	broad.mit.edu	37	chr12	58140808	58140808	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttttatcctcagatctgcaAgagccagagccccacatgcc	10	9	8	14	0	2	3	1	0	1	3	3	3	3	3	5	0	4	2	5	0	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:58140808A>G	uc001spt.2	+	5	606	c.452A>G	c.(451-453)AAG>AGG	p.K151R	TSPAN31_uc009zqb.2_Missense_Mutation_p.K67R|TSPAN31_uc010ssa.1_Missense_Mutation_p.K73R	NM_005981	NP_005972	Q12999	TSN31_HUMAN	sarcoma amplified sequence	151	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane|membrane fraction					0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CAGATCTGCAAGAGCCAGAGC	0.423													4	164					0	0	0	0	G	58140808	G	G	58140808	3	3	130	1	0	0	0	0	1	0	0	0	16713	72	3	5	470	5	TSPAN31	12	58140808	Missense_Mutation	SNP	A	TCGA-CR-6484-01A-11D-1870-08	1322259	58140808	75711087	204	23436											
TMTC2	160335	broad.mit.edu	37	chr12	83455572	83455572	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctagcctcaatgaagcagctGagaagtattatgatctggca	13	10	10	8	0	2	3	1	3	1	1	2	4	2	3	1	1	3	4	1	1	6	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:83455572G>C	uc001szt.2	+	11	2725	c.2293G>C	c.(2293-2295)GAG>CAG	p.E765Q	TMTC2_uc010suk.1_Missense_Mutation_p.E520Q	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	765	TPR 9.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						TGAAGCAGCTGAGAAGTATTA	0.353													13	73					0	0	0	0	C	83455572	C	C	83455572	3	2	130	1	0	0	0	0	1	0	0	0	16327	1291	45	2	2335	2	TMTC2	12	83455572	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	25314764	83455572	50396323	205	23437											
APAF1	317	broad.mit.edu	37	chr12	99093306	99093306	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgttgttcgtggtctgctGatggtgcaaggataatggtg	7	14	16	4	1	1	1	0	1	1	0	2	2	1	2	0	4	2	4	0	4	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr12:99093306G>A	uc001tfz.2	+	17	3002	c.2425G>A	c.(2425-2427)GAT>AAT	p.D809N	APAF1_uc001tfy.2_Missense_Mutation_p.D798N|APAF1_uc001tga.2_Missense_Mutation_p.D798N|APAF1_uc001tgb.2_Missense_Mutation_p.D809N|APAF1_uc001tgc.2_Intron|APAF1_uc009zto.2_Missense_Mutation_p.D218N	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	809	WD 5.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	GTGGTCTGCTGATGGTGCAAG	0.358													10	49					0	0	0	0	A	99093306	A	A	99093306	3	1	130	1	0	0	0	0	1	0	0	0	755	1290	45	2	2487	2	APAF1	12	99093306	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	15637734	99093306	34758589	206	23438											
EFHA1	221154	broad.mit.edu	37	chr13	22113514	22113514	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgacagtgtatcctcgatGtcctttgaatacacatatta	11	14	6	10	1	0	2	0	2	0	0	3	3	2	2	3	0	1	1	3	0	5	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr13:22113514G>A	uc001uof.2	-	4	415	c.393C>T	c.(391-393)GAC>GAT	p.D131D		NM_152726	NP_689939	Q8IYU8	EFHA1_HUMAN	EF-hand domain family, member A1	131							calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)		TATCCTCGATGTCCTTTGAAT	0.254													16	22					0	0	0	0	A	22113514	A	A	22113514	2	1	130	1	0	0	0	0	0	0	0	1	4965	1368	48	4		4	EFHA1	13	22113514	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08		22113514	93056364	207	23439											
SACS	26278	broad.mit.edu	37	chr13	23913992	23913992	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgagatcttggtcacttttGagatatatcttctgaataac	11	16	7	7	0	4	3	1	3	3	2	4	5	4	3	0	1	1	0	0	1	4	7			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr13:23913992G>C	uc001uon.2	-	10	4612	c.4023C>G	c.(4021-4023)CTC>CTG	p.L1341L	SACS_uc001uoo.2_Silent_p.L1194L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1341					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GGTCACTTTTGAGATATATCT	0.358													12	40					0	0	0	0	C	23913992	C	C	23913992	2	2	130	1	0	0	0	0	0	0	0	1	13869	1277	45	2		2	SACS	13	23913992	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1800478	23913992	91255886	208	23440											
C1QTNF9B	387911	broad.mit.edu	37	chr13	24471143	24471143	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catggttcagatgacagactGaactgaaagagggaaacaga	17	6	12	6	0	1	7	1	3	0	4	1	8	1	8	0	2	2	1	0	2	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr13:24471143G>A	uc010tcw.1	-						C1QTNF9B_uc010tcv.1_5'UTR|C1QTNF9B_uc001uoz.1_5'UTR|C1QTNF9B_uc010tcx.1_5'UTR	NM_001007537	NP_001007538	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B							collagen					0						ATGACAGACTGAACTGAAAGA	0.532													22	62					0	0	0	0	A	24471143	A	A	24471143	1	1	130	0	1	0	0	0	0	0	0	0	1980	1305	45	2		2	C1QTNF9B	13	24471143	5'Flank	SNP	G	TCGA-CR-6484-01A-11D-1870-08	557151	24471143	90698735	209	23441											
FLT1	2321	broad.mit.edu	37	chr13	28913326	28913326	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtttaagtctctcccgggCaaactcccacttgctggcat	8	11	8	14	1	1	0	0	0	1	0	4	0	3	0	2	2	2	4	2	2	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr13:28913326C>A	uc001usb.3	-	17	2752	c.2467G>T	c.(2467-2469)GCC>TCC	p.A823S	FLT1_uc001usa.3_Missense_Mutation_p.A41S	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	823	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTCTCCCGGGCAAACTCCCAC	0.313													4	54					0.000602214	0.000625569	1	0	A	28913326	A	A	28913326	3	1	130	1	0	0	0	0	1	0	0	0	5973	710	25	4	1605	4	FLT1	13	28913326	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	4442183	28913326	86256552	210	23442											
KIAA0564	23078	broad.mit.edu	37	chr13	42352181	42352181	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttcagcatatcttccatCactatcacatgctagagaaa	13	13	4	11	0	5	1	3	0	2	1	6	2	6	1	1	0	2	2	1	0	4	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr13:42352181C>T	uc001uyj.2	-	20	2359	c.2289G>A	c.(2287-2289)GTG>GTA	p.V763V	KIAA0564_uc001uyk.2_Silent_p.V763V	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	763						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		TATCTTCCATCACTATCACAT	0.323													14	128					0	0	0	0	T	42352181	T	T	42352181	2	4	130	1	0	0	0	0	0	0	0	1	8224	813	29	2		2	KIAA0564	13	42352181	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	13438855	42352181	72817697	211	23443											
LRCH1	23143	broad.mit.edu	37	chr13	47303005	47303005	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgagatgagattgaaggtCagtctacacgaagacctggg	13	9	13	6	1	2	4	1	3	1	3	2	7	2	4	1	2	1	0	1	2	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr13:47303005C>T	uc001vbj.2	+	17	2024	c.1788C>T	c.(1786-1788)GTC>GTT	p.V596V	LRCH1_uc001vbk.2_Silent_p.V631V|LRCH1_uc001vbl.3_Silent_p.V596V	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	596	CH.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GATTGAAGGTCAGTCTACACG	0.488													18	117					0	0	0	0	T	47303005	T	T	47303005	2	4	130	1	0	0	0	0	0	0	0	1	8982	813	29	2		2	LRCH1	13	47303005	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	4950824	47303005	67866873	212	23444											
OLFM4	10562	broad.mit.edu	37	chr13	53603067	53603067	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacctccaattcccagcccCggcttcagctctttcccagg	6	9	8	18	1	2	0	1	0	1	0	5	1	5	1	6	3	2	2	6	3	1	3	rs140749392		TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr13:53603067C>G	uc001vhl.2	+	1	96	c.96C>G	c.(94-96)CCC>CCG	p.P32P	OLFM4_uc001vhk.1_Silent_p.P32P	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	32	Ser-rich.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		TTCCCAGCCCCGGCTTCAGCT	0.418													9	165					0	0	0	0	G	53603067	G	G	53603067	2	3	130	1	0	0	0	0	0	0	0	1	10909	639	23	3		3	OLFM4	13	53603067	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	6300062	53603067	61566811	213	23445											
HECTD1	25831	broad.mit.edu	37	chr14	31637671	31637671	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cctttattaactggacacatCcaatcacctacagacaaata	16	10	3	12	0	1	1	1	0	0	1	2	2	2	2	3	1	2	0	3	1	6	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr14:31637671C>G	uc001wrc.1	-	10	1944	c.1455G>C	c.(1453-1455)TGG>TGC	p.W485C	HECTD1_uc001wrd.1_5'UTR	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	485	ANK 3.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CTGGACACATCCAATCACCTA	0.308													19	145					0	0	0	0	G	31637671	G	G	31637671	3	3	130	1	0	0	0	0	1	0	0	0	7078	856	30	2	6513	2	HECTD1	14	31637671	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08		31637671	75711869	214	23446											
PNN	5411	broad.mit.edu	37	chr14	39650613	39650613	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaagtagaggtcgagctaGaaataaaacaagcaagagta	20	5	11	5	1	0	4	0	0	0	4	1	5	0	4	0	1	3	4	0	1	9	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr14:39650613G>C	uc001wuw.3	+	9	1797	c.1700G>C	c.(1699-1701)AGA>ACA	p.R567T		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	567	Ser-rich.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		GGTCGAGCTAGAAATAAAACA	0.254													4	52					0	0	0	0	C	39650613	C	C	39650613	3	2	130	1	0	0	0	0	1	0	0	0	12215	942	33	2	1734	2	PNN	14	39650613	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	8012942	39650613	67698927	215	23447											
SAV1	60485	broad.mit.edu	37	chr14	51102087	51102087	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctggaagagttcccacttCagaatgtggtcatatctgtt	10	13	10	8	0	3	2	2	0	1	2	4	3	4	3	1	2	1	3	1	2	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr14:51102087C>T	uc001wyg.1	-	6	1127	c.966G>A	c.(964-966)CTG>CTA	p.L322L	SAV1_uc001wyh.1_Silent_p.L322L	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	WW45 protein	322	SARAH.				hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)	1	all_epithelial(31;0.000611)|Breast(41;0.0333)					GTTCCCACTTCAGAATGTGGT	0.343													11	30					0	0	0	0	T	51102087	T	T	51102087	2	4	130	1	0	0	0	0	0	0	0	1	13921	813	29	2		2	SAV1	14	51102087	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	11451474	51102087	56247453	216	23448											
PPM1A	5494	broad.mit.edu	37	chr14	60749451	60749451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttttagacaagccaaagatGgaaaagcataatgcccaggg	16	8	10	7	0	0	2	0	0	0	2	0	3	0	3	2	2	3	1	2	2	6	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr14:60749451G>A	uc010apn.2	+	3	432	c.30G>A	c.(28-30)ATG>ATA	p.M10I	PPM1A_uc001xew.3_Missense_Mutation_p.M83I|PPM1A_uc001xex.3_Missense_Mutation_p.M10I|PPM1A_uc001xey.3_Missense_Mutation_p.M10I	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	10					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		AGCCAAAGATGGAAAAGCATA	0.443													15	164					0	0	0	0	A	60749451	A	A	60749451	3	1	130	1	0	0	0	0	1	0	0	0	12395	1348	47	4	255	4	PPM1A	14	60749451	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	9647364	60749451	46600089	217	23449											
PRKCH	5583	broad.mit.edu	37	chr14	61952289	61952289	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccacattcagaagtctcgtCgttttgatgaagcacgagct	10	12	9	10	3	2	3	1	2	1	1	5	4	3	3	1	0	2	3	1	0	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr14:61952289C>T	uc001xfn.2	+	10	1653	c.1348C>T	c.(1348-1350)CGT>TGT	p.R450C	PRKCH_uc010tsa.1_Missense_Mutation_p.R289C|PRKCH_uc010tsb.1_Missense_Mutation_p.R18C	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	450	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		GAAGTCTCGTCGTTTTGATGA	0.443													37	273					0	0	0	0	T	61952289	T	T	61952289	3	4	130	1	0	0	0	0	1	0	0	0	12575	884	31	1	1386	1	PRKCH	14	61952289	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1202838	61952289	45397251	218	23450											
FCF1	51077	broad.mit.edu	37	chr14	75200790	75200790	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcttacagcataagtgttaCattgtggccacagttgaccg	10	12	9	10	1	1	1	0	1	1	0	1	1	1	1	2	1	3	3	2	1	3	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr14:75200790C>T	uc001xqh.2	+	7	516	c.465C>T	c.(463-465)TAC>TAT	p.Y155Y	FCF1_uc001xqf.1_Silent_p.Y140Y|FCF1_uc001xqg.2_RNA|FCF1_uc001xqi.2_RNA	NM_015962	NP_057046	Q9Y324	FCF1_HUMAN	FCF1 small subunit	155	PINc.				rRNA processing	nucleolus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0037)		ATAAGTGTTACATTGTGGCCA	0.443													10	41					0	0	0	0	T	75200790	T	T	75200790	2	4	130	1	0	0	0	0	0	0	0	1	5809	489	17	4		4	FCF1	14	75200790	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	13248501	75200790	32148750	219	23451											
OTUB2	78990	broad.mit.edu	37	chr14	94511037	94511037	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcgtgcagttcctgcgcCtgctcacgtcggccttcatc	5	11	9	16	4	2	0	2	0	0	0	6	0	3	0	3	1	3	3	3	1	0	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr14:94511037C>G	uc001yci.2	+	5	569	c.409C>G	c.(409-411)CTG>GTG	p.L137V		NM_023112	NP_075601	Q96DC9	OTUB2_HUMAN	OTU domain, ubiquitin aldehyde binding 2	137	OTU.				cellular amino acid metabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination		omega peptidase activity|protein binding|ubiquitin-specific protease activity				0		all_cancers(154;0.12)		Epithelial(152;0.124)|all cancers(159;0.21)|COAD - Colon adenocarcinoma(157;0.215)		GTTCCTGCGCCTGCTCACGTC	0.552													3	35					0	0	0	0	G	94511037	G	G	94511037	3	3	130	1	0	0	0	0	1	0	0	0	11366	680	24	4	427	4	OTUB2	14	94511037	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	19310247	94511037	12838503	220	23452											
EML1	2009	broad.mit.edu	37	chr14	100363569	100363569	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcatcgcatccgtggtggtGttatacaacgtggaggagca	9	11	13	8	3	1	0	1	0	0	0	3	2	2	2	1	4	3	3	1	4	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr14:100363569G>A	uc001ygs.2	+	7	834	c.765G>A	c.(763-765)GTG>GTA	p.V255V	EML1_uc010avt.1_Silent_p.V242V|EML1_uc010tww.1_Silent_p.V243V|EML1_uc001ygq.2_Silent_p.V274V|EML1_uc001ygr.2_Silent_p.V274V	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	255						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				CCGTGGTGGTGTTATACAACG	0.483													9	57					0	0	0	0	A	100363569	A	A	100363569	2	1	130	1	0	0	0	0	0	0	0	1	5120	1364	48	4		4	EML1	14	100363569	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	5852532	100363569	6985971	221	23453											
RYR3	6263	broad.mit.edu	37	chr15	33955886	33955886	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaggccctgaacatgtctgCggccctgactgcccggaaga	8	6	13	14	2	1	3	0	2	1	1	1	4	1	4	3	3	3	1	3	3	2	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:33955886C>T	uc001zhi.2	+	36	5637	c.5567C>T	c.(5566-5568)GCG>GTG	p.A1856V	RYR3_uc010bar.2_Missense_Mutation_p.A1856V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1856	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AACATGTCTGCGGCCCTGACT	0.552													3	15					0	0	0	0	T	33955886	T	T	33955886	3	4	130	1	0	0	0	0	1	0	0	0	13835	768	27	1	5709	1	RYR3	15	33955886	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08		33955886	68575506	222	23454											
PAK6	56924	broad.mit.edu	37	chr15	40565875	40565875	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggtctttgtatgccactGaggtaaccgttccctccacc	7	11	8	15	1	1	1	0	1	1	0	3	1	3	1	6	2	2	3	6	2	2	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:40565875G>T	uc010bbl.2	+	9	2181	c.1741G>T	c.(1741-1743)GAG>TAG	p.E581*	PAK6_uc010bbm.2_Nonsense_Mutation_p.E581*|PAK6_uc001zky.3_Nonsense_Mutation_p.E581*|PAK6_uc010bbn.2_Nonsense_Mutation_p.E581*|PAK6_uc001zlb.2_Nonsense_Mutation_p.E581*	NM_001128628	NP_001122100	Q9NQU5	PAK6_HUMAN	p21-activated kinase 6	581	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(5)|large_intestine(1)|ovary(1)|skin(1)	8		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		GTATGCCACTGAGGTAACCGT	0.572													7	43					8.12818e-05	8.53801e-05	1	0	T	40565875	T	T	40565875	4	4	130	1	0	0	0	0	0	1	0	0	11458	1291	45	2	1763	2	PAK6	15	40565875	Nonsense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6609989	40565875	61965517	223	23455											
PLCB2	5330	broad.mit.edu	37	chr15	40582261	40582261	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactacttcctggatgtgggAgttgttaatctctctcttca	7	16	8	10	0	3	0	1	0	2	0	6	2	4	2	1	2	1	2	1	2	2	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:40582261A>G	uc001zld.2	-	30	3533	c.3232T>C	c.(3232-3234)TCC>CCC	p.S1078P	PLCB2_uc001zlc.2_Missense_Mutation_p.S62P|PLCB2_uc010bbo.2_Missense_Mutation_p.S1074P|PLCB2_uc010ucm.1_Missense_Mutation_p.S1063P	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	1078	Potential.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		TGGATGTGGGAGTTGTTAATC	0.373													4	101					0	0	0	0	G	40582261	G	G	40582261	3	3	130	1	0	0	0	0	1	0	0	0	12083	304	11	5	337	5	PLCB2	15	40582261	Missense_Mutation	SNP	A	TCGA-CR-6484-01A-11D-1870-08	16386	40582261	61949131	224	23456											
INO80	54617	broad.mit.edu	37	chr15	41387980	41387980	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgtagaactccattcagaGaatatgtgtttaacattcca	14	13	6	8	0	1	2	1	0	0	2	3	3	3	2	2	0	2	2	2	0	5	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:41387980G>A	uc001zni.2	-	3	503	c.290C>T	c.(289-291)TCT>TTT	p.S97F	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	97	Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TCCATTCAGAGAATATGTGTT	0.418													6	73					0	0	0	0	A	41387980	A	A	41387980	3	1	130	1	0	0	0	0	1	0	0	0	7785	942	33	2	4516	2	INO80	15	41387980	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	805719	41387980	61143412	225	23457											
OIP5	11339	broad.mit.edu	37	chr15	41624610	41624610	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcccccagccctgcggggccGagcggcgaggaccccttcac	5	3	14	19	4	1	0	1	0	0	0	1	3	1	1	6	4	3	0	6	4	0	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:41624610G>C	uc001znp.2	-	1	210	c.150C>G	c.(148-150)CTC>CTG	p.L50L	NUSAP1_uc001znq.3_5'Flank|NUSAP1_uc001znr.3_5'Flank|NUSAP1_uc001zns.3_5'Flank|NUSAP1_uc010bce.2_5'Flank|NUSAP1_uc001znt.3_5'Flank|NUSAP1_uc001znv.3_5'Flank|NUSAP1_uc001znu.3_5'Flank|NUSAP1_uc010ucw.1_5'Flank	NM_007280	NP_009211	O43482	MS18B_HUMAN	Opa interacting protein 5	50					cell communication|cell division|CenH3-containing nucleosome assembly at centromere|mitosis	Cajal body|chromatin|chromosome, centromeric region	protein binding				0		all_cancers(109;4.16e-14)|all_epithelial(112;7.09e-12)|Lung NSC(122;1.14e-09)|all_lung(180;2.56e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)		OV - Ovarian serous cystadenocarcinoma(18;1.49e-16)|GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.163)		CTGCGGGGCCGAGCGGCGAGG	0.662													13	58					0	0	0	0	C	41624610	C	C	41624610	2	2	130	1	0	0	0	0	0	0	0	1	10902	1045	37	3		3	OIP5	15	41624610	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	236630	41624610	60906782	226	23458											
LTK	4058	broad.mit.edu	37	chr15	41804373	41804373	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tacagcgactccccgagaccGagggagaagattgctgagac	12	5	13	11	3	0	4	0	1	0	4	1	9	1	4	3	1	3	1	3	1	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:41804373G>C	uc001zoa.3	-	4	628	c.450C>G	c.(448-450)CTC>CTG	p.L150L	LTK_uc001zob.3_Silent_p.L150L|LTK_uc010ucx.1_Silent_p.L150L|LTK_uc010bcg.2_Intron	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	150	Extracellular (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CCCCGAGACCGAGGGAGAAGA	0.602										TSP Lung(18;0.14)			3	29					0	0	0	0	C	41804373	C	C	41804373	2	2	130	1	0	0	0	0	0	0	0	1	9130	1045	37	3		3	LTK	15	41804373	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	179763	41804373	60727019	227	23459											
PYGO1	26108	broad.mit.edu	37	chr15	55838571	55838571	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttgtcgtggcttattctGcgtcccatttgcagggttat	4	17	12	8	2	1	0	0	0	1	0	3	0	2	0	1	3	2	4	1	3	2	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:55838571G>A	uc010bfl.1	-	3	966	c.910C>T	c.(910-912)CAG>TAG	p.Q304*	PYGO1_uc002adf.1_Nonsense_Mutation_p.Q304*	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	304	Asn-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		GGCTTATTCTGCGTCCCATTT	0.433													49	323					0	0	0	0	A	55838571	A	A	55838571	4	1	130	1	0	0	0	0	0	1	0	0	12928	1328	46	4	353	4	PYGO1	15	55838571	Nonsense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	14034198	55838571	46692821	228	23460											
TLN2	83660	broad.mit.edu	37	chr15	62993361	62993361	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaaacacgaaatccattcTcaagttgatgctatcacggc	13	10	6	12	2	2	1	2	1	1	0	5	2	4	1	2	1	2	2	2	1	4	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:62993361T>C	uc002alb.3	+	14	1644	c.1644T>C	c.(1642-1644)TCT>TCC	p.S548S		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	548					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						AAATCCATTCTCAAGTTGATG	0.468													7	78					0	0	0	0	C	62993361	C	C	62993361	2	2	130	1	0	0	0	0	0	0	0	1	16014	1538	54	5		5	TLN2	15	62993361	Silent	SNP	T	TCGA-CR-6484-01A-11D-1870-08	7154790	62993361	39538031	229	23461											
RASL12	51285	broad.mit.edu	37	chr15	65350896	65350896	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctggcggctgtcgacgctGtacaccaccaggaaggcatg	8	7	13	13	3	1	0	0	0	1	0	2	2	1	1	2	4	1	4	2	4	2	1	rs147666289		TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:65350896G>A	uc002aoi.1	-	4	509	c.294C>T	c.(292-294)TAC>TAT	p.Y98Y	RASL12_uc002aoj.1_Silent_p.Y79Y|RASL12_uc010uir.1_Silent_p.Y87Y	NM_016563	NP_057647	Q9NYN1	RASLC_HUMAN	RAS-like, family 12 protein	98					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			skin(1)	1						TGTCGACGCTGTACACCACCA	0.652													10	43					0	0	0	0	A	65350896	A	A	65350896	2	1	130	1	0	0	0	0	0	0	0	1	13148	1372	48	4		4	RASL12	15	65350896	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2357535	65350896	37180496	230	23462											
EDC3	80153	broad.mit.edu	37	chr15	74967310	74967310	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggacactcacctgaaggtGacttctggaacaagacactt	13	8	9	11	0	2	3	1	2	1	1	2	5	2	5	1	3	1	0	1	3	3	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:74967310G>A	uc002ayn.2	-	5	644	c.156C>T	c.(154-156)GTC>GTT	p.V52V	EDC3_uc002ayo.2_Silent_p.V52V|EDC3_uc002aym.2_Silent_p.V52V	NM_001142443	NP_001135915	Q96F86	EDC3_HUMAN	enhancer of mRNA decapping 3	52	Required for P-body targeting and interaction with DCP1A (By similarity).				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1						ACCTGAAGGTGACTTCTGGAA	0.498													29	176					0	0	0	0	A	74967310	A	A	74967310	2	1	130	1	0	0	0	0	0	0	0	1	4929	1277	45	2		2	EDC3	15	74967310	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	9616414	74967310	27564082	231	23463											
KIAA1199	57214	broad.mit.edu	37	chr15	81181841	81181841	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacggagtggttcgatcatGataaagtatctcagactaaa	14	10	11	6	2	2	2	2	1	1	1	4	5	2	4	0	3	0	2	0	3	5	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:81181841G>C	uc002bfw.1	+	9	1254	c.994G>C	c.(994-996)GAT>CAT	p.D332H	KIAA1199_uc010unn.1_Missense_Mutation_p.D332H	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	332										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GTTCGATCATGATAAAGTATC	0.463													3	87					0	0	0	0	C	81181841	C	C	81181841	3	2	130	1	0	0	0	0	1	0	0	0	8252	1290	45	2	1024	2	KIAA1199	15	81181841	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6214531	81181841	21349551	232	23464											
MEX3B	84206	broad.mit.edu	37	chr15	82336881	82336881	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcctgcccgtcacaacaaaGacaggctcctccccgcgaac	10	6	7	18	3	1	1	1	0	0	1	4	2	4	1	5	1	3	1	5	1	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:82336881G>C	uc002bgq.1	-	2	645	c.330C>G	c.(328-330)GTC>GTG	p.V110V		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	110	KH 1.				protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						TCACAACAAAGACAGGCTCCT	0.577													11	51					0	0	0	0	C	82336881	C	C	82336881	2	2	130	1	0	0	0	0	0	0	0	1	9563	929	33	2		2	MEX3B	15	82336881	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1155040	82336881	20194511	233	23465											
CPEB1	64506	broad.mit.edu	37	chr15	83226644	83226644	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgagggtgctggaaacttgtCcaccaagtcagacccaaggg	11	7	13	10	0	1	2	1	1	0	1	2	3	2	3	3	3	2	1	3	3	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:83226644C>G	uc002bit.2	-	4	789	c.652G>C	c.(652-654)GAC>CAC	p.D218H	CPEB1_uc002biq.2_Missense_Mutation_p.D83H|CPEB1_uc002bir.2_Missense_Mutation_p.D83H|CPEB1_uc002bis.2_Missense_Mutation_p.D83H|CPEB1_uc010uod.1_Intron|CPEB1_uc010uoe.1_Missense_Mutation_p.D161H|CPEB1_uc002biu.2_Missense_Mutation_p.D185H|CPEB1_uc010uof.1_Missense_Mutation_p.D83H|CPEB1_uc002biv.2_Missense_Mutation_p.D158H|CPEB1_uc002bip.2_5'Flank	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	158					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGAAACTTGTCCACCAAGTCA	0.567													9	87					0	0	0	0	G	83226644	G	G	83226644	3	3	130	1	0	0	0	0	1	0	0	0	3815	855	30	2	1264	2	CPEB1	15	83226644	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	889763	83226644	19304748	234	23466											
ABHD2	11057	broad.mit.edu	37	chr15	89738457	89738457	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagctgcgtttcccctgcaGagaaacgagagaacgtcatg	11	8	11	11	3	2	2	2	0	0	2	3	5	3	2	2	0	5	3	2	0	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:89738457G>C	uc002bnj.2	+	16	1999	c.1082_splice	c.e16-1	p.E361_splice	ABHD2_uc002bnk.2_Splice_Site_p.E361_splice	NM_007011	NP_008942	P08910	ABHD2_HUMAN	alpha/beta hydrolase domain containing protein							integral to membrane	carboxylesterase activity			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TTCCCCTGCAGAGAAACGAGA	0.582													19	81					0	0	0	0	C	89738457	C	C	89738457	5	2	130	1	0	0	0	0	0	0	1	0	82	956	33	2	1115	2	ABHD2	15	89738457	Splice_Site	SNP	G	TCGA-CR-6484-01A-11D-1870-08	6511813	89738457	12792935	235	23467											
PLIN1	5346	broad.mit.edu	37	chr15	90210983	90210983	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgctcctccgccgggacacCgcctgcatggccactgaggc	5	6	12	18	4	0	1	0	1	0	0	3	2	2	2	6	3	1	2	6	3	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr15:90210983C>T	uc010upx.1	-	7	923	c.813G>A	c.(811-813)GCG>GCA	p.A271A	PLIN1_uc002boh.2_Silent_p.A271A	NM_001145311	NP_001138783	O60240	PLIN1_HUMAN	perilipin 1	271					triglyceride catabolic process	lipid particle	lipid binding			central_nervous_system(1)|skin(1)	2						GCCGGGACACCGCCTGCATGG	0.552													3	6					0	0	0	0	T	90210983	T	T	90210983	2	4	130	1	0	0	0	0	0	0	0	1	12144	639	23	1		1	PLIN1	15	90210983	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	472526	90210983	12320409	236	23468											
ITFG3	83986	broad.mit.edu	37	chr16	313748	313748	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaccttggctgtagccgttGaaaacggaactggcaccgac	11	7	11	12	3	0	1	0	1	0	0	0	3	0	2	3	3	3	4	3	3	4	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:313748G>C	uc002cgf.2	+	10	1357	c.1162G>C	c.(1162-1164)GAA>CAA	p.E388Q	ITFG3_uc002cgg.2_Missense_Mutation_p.E388Q|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.E388Q	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	388	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				TGTAGCCGTTGAAAACGGAAC	0.537													12	58					0	0	0	0	C	313748	C	C	313748	3	2	130	1	0	0	0	0	1	0	0	0	7910	1291	45	2	1192	2	ITFG3	16	313748	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08		313748	90041005	237	23469											
IFT140	9742	broad.mit.edu	37	chr16	1621494	1621494	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgtccaagaagcagggattCccctcagtctccgagaaaag	13	7	10	11	1	2	2	1	0	1	2	5	4	4	3	4	1	1	1	4	1	4	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:1621494C>T	uc002cmb.2	-	14	1928	c.1566G>A	c.(1564-1566)GGG>GGA	p.G522G	IFT140_uc002clz.2_Silent_p.G173G	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	522										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				AGCAGGGATTCCCCTCAGTCT	0.413													3	43					0	0	0	0	T	1621494	T	T	1621494	2	4	130	1	0	0	0	0	0	0	0	1	7595	842	30	2		2	IFT140	16	1621494	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1307746	1621494	88733259	238	23470											
RNF151	146310	broad.mit.edu	37	chr16	2017315	2017315	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcttcgccagccctcctgAcagcaacttcgtgtgctccg	5	10	8	18	3	1	1	0	1	1	0	5	1	3	1	5	0	4	2	5	0	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:2017315A>G	uc002cnt.1	+	2	52	c.44A>G	c.(43-45)GAC>GGC	p.D15G	RPS2_uc010bsa.1_5'Flank|RPS2_uc002cnl.2_5'Flank|RPS2_uc002cnm.2_5'Flank|RPS2_uc002cnn.2_5'Flank|RPS2_uc002cno.2_5'Flank	NM_174903	NP_777563	Q2KHN1	RN151_HUMAN	ring finger protein 151	15					cell differentiation|spermatogenesis	cytoplasm|nucleus	ubiquitin-protein ligase activity|zinc ion binding				0						AGCCCTCCTGACAGCAACTTC	0.582													8	50					0	0	0	0	G	2017315	G	G	2017315	3	3	130	1	0	0	0	0	1	0	0	0	13517	275	10	5	50	5	RNF151	16	2017315	Missense_Mutation	SNP	A	TCGA-CR-6484-01A-11D-1870-08	395821	2017315	88337438	239	23471											
ITPRIPL2	162073	broad.mit.edu	37	chr16	19126188	19126188	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctggtgcgggctggccgCgcccgggggtcccccggtct	1	6	19	15	5	1	0	0	0	1	0	2	1	2	0	4	6	2	2	4	6	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:19126188C>A	uc002dfu.3	+	1	935	c.405C>A	c.(403-405)CGC>CGA	p.R135R	ITPRIPL2_uc002dft.2_5'UTR	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	135	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						GGGCTGGCCGCGCCCGGGGGT	0.667													3	6					6.4e-05	6.74157e-05	1	0	A	19126188	A	A	19126188	2	1	130	1	0	0	0	0	0	0	0	1	7964	755	27	3		3	ITPRIPL2	16	19126188	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	17108873	19126188	71228565	240	23472											
ANKS4B	257629	broad.mit.edu	37	chr16	21261527	21261527	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaagttcaagaagaacaaaGatacagcagaacaggtgggg	18	5	12	6	0	2	4	2	0	0	4	2	4	2	4	0	3	4	2	0	3	7	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:21261527G>C	uc010bwp.1	+	2	683	c.640G>C	c.(640-642)GAT>CAT	p.D214H	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	214										ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		GAAGAACAAAGATACAGCAGA	0.478													8	72					0	0	0	0	C	21261527	C	C	21261527	3	2	130	1	0	0	0	0	1	0	0	0	691	942	33	2	646	2	ANKS4B	16	21261527	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2135339	21261527	69093226	241	23473			2	33		4	3	465	N	G	1.158453e-05
ANKS4B	257629	broad.mit.edu	37	chr16	21261721	21261721	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggaagtattgtttttagaagGaacaggatatcgagtcctga	13	12	12	4	1	0	2	0	1	0	1	2	6	1	5	1	3	1	2	1	3	6	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:21261721G>T	uc010bwp.1	+	2	877	c.834G>T	c.(832-834)AGG>AGT	p.R278S	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	278										ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		TTTTTAGAAGGAACAGGATAT	0.453													8	81					1.26484e-09	1.37086e-09	1	0	T	21261721	T	T	21261721	3	4	130	1	0	0	0	0	1	0	0	0	691	1165	41	2	840	2	ANKS4B	16	21261721	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	194	21261721	69093032	242	23474			2	33		4	3	465	N	G	1.158453e-05
ANKS4B	257629	broad.mit.edu	37	chr16	21261982	21261982	+	Missense_Mutation	SNP	G	T	T																															gaattcctgcctatcttcaaGagagagcagattgatctaga																										TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:21261982G>T	uc010bwp.1	+	2	1138	c.1095G>T	c.(1093-1095)AAG>AAT	p.K365N	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	365	SAM.									ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		CTATCTTCAAGAGAGAGCAGA	0.502													9	69					0.000274275	0.000285703	1	0	T	21261982	T	T	21261982	3	4	130	1	0	0	0	0	1	0	0	0	691	933	33	2	1101	2	ANKS4B	16	21261982	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	261	21261982	69092771	243	23475	50	2	2	33		4	3	465	N	G	1.158453e-05
ANKS4B	257629	broad.mit.edu	37	chr16	21261991	21261991	+	Missense_Mutation	SNP	G	T	T																															cctatcttcaagagagagcaGattgatctagaagctctgct																										TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:21261991G>T	uc010bwp.1	+	2	1147	c.1104G>T	c.(1102-1104)CAG>CAT	p.Q368H	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	368	SAM.									ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		AGAGAGAGCAGATTGATCTAG	0.502													11	78					0.000673444	0.000697628	1	0	T	21261991	T	T	21261991	3	4	130	1	0	0	0	0	1	0	0	0	691	933	33	2	1110	2	ANKS4B	16	21261991	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	9	21261991	69092762	244	23476	50	2	2	33		4	3	465	N	G	1.158453e-05
METTL9	51108	broad.mit.edu	37	chr16	21624068	21624068	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttcttaaacaacagcattGagaaatcgggctggctattt	12	13	8	8	1	2	1	0	1	2	1	3	2	2	1	0	2	3	3	0	2	5	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:21624068G>A	uc002dje.2	+	2	467	c.268G>A	c.(268-270)GAG>AAG	p.E90K	uc002diq.3_Intron|METTL9_uc002djf.2_Missense_Mutation_p.E90K	NM_016025	NP_057109	Q9H1A3	METL9_HUMAN	methyltransferase like 9 isoform 1	90										ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0759)		CAACAGCATTGAGAAATCGGG	0.373													6	73					0	0	0	0	A	21624068	A	A	21624068	3	1	130	1	0	0	0	0	1	0	0	0	9561	1291	45	2	274	2	METTL9	16	21624068	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	362077	21624068	68730685	245	23477											
BCL7C	9274	broad.mit.edu	37	chr16	30904177	30904177	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctaccattaagatccagcagGatgagagggccaccccctcg	11	6	10	14	1	0	2	0	1	0	2	2	4	1	3	5	2	2	1	5	2	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:30904177G>A	uc002dzv.2	-	3	398	c.264C>T	c.(262-264)ATC>ATT	p.I88I	BCL7C_uc002dzt.1_Silent_p.I88I|uc002dzu.2_Intron|MIR762_hsa-mir-762|MI0003892_5'Flank	NM_004765	NP_004756	Q8WUZ0	BCL7C_HUMAN	B-cell CLL/lymphoma 7C	88					apoptosis						0			Colorectal(24;0.198)			GATCCAGCAGGATGAGAGGGC	0.662													18	105					0	0	0	0	A	30904177	A	A	30904177	2	1	130	1	0	0	0	0	0	0	0	1	1382	1164	41	2		2	BCL7C	16	30904177	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	9280109	30904177	59450576	246	23478											
PRSS53	339105	broad.mit.edu	37	chr16	31095655	31095655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagtggtgccccagacaggCcctgtcaggggtcaggtgac	7	6	15	13	0	2	2	2	1	0	1	2	2	2	2	4	5	1	0	4	5	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:31095655C>T	uc002eaq.2	-	10	1427	c.1427G>A	c.(1426-1428)GGC>GAC	p.G476D	PRSS53_uc002ear.2_Missense_Mutation_p.G270D	NM_001039503	NP_001034592	Q2L4Q9	PRS53_HUMAN	polyserase 3 precursor	476	Peptidase S1 2.				proteolysis	extracellular region	serine-type endopeptidase activity				0						CCCAGACAGGCCCTGTCAGGG	0.632													3	32					0	0	0	0	T	31095655	T	T	31095655	3	4	130	1	0	0	0	0	1	0	0	0	12694	753	26	4	242	4	PRSS53	16	31095655	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	191478	31095655	59259098	247	23479											
CCDC102A	92922	broad.mit.edu	37	chr16	57555060	57555060	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagctccccctctagcttctCaatgttcctgctcaacgcca	7	11	6	17	1	3	0	2	0	2	0	6	1	5	0	4	0	4	4	4	0	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:57555060C>T	uc002elw.2	-	4	1054	c.841G>A	c.(841-843)GAG>AAG	p.E281K		NM_033212	NP_149989	Q96A19	C102A_HUMAN	coiled-coil domain containing 102A	281	Potential.									ovary(1)	1						TCTAGCTTCTCAATGTTCCTG	0.572													8	73					0	0	0	0	T	57555060	T	T	57555060	3	4	130	1	0	0	0	0	1	0	0	0	2748	835	29	2	835	2	CCDC102A	16	57555060	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	26459405	57555060	32799693	248	23480											
CCDC135	84229	broad.mit.edu	37	chr16	57741450	57741450	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgtgctatcggggaagcgcGaggtgcctgagaacttcttc	7	11	14	9	3	1	1	0	1	1	1	3	4	1	2	1	3	4	1	1	3	3	4	rs116219187	by1000genomes	TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:57741450G>A	uc002emi.2	+	7	1026	c.937G>A	c.(937-939)GAG>AAG	p.E313K	CCDC135_uc002emj.2_Missense_Mutation_p.E313K|CCDC135_uc002emk.2_Missense_Mutation_p.E248K	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	313						cytoplasm				central_nervous_system(1)	1						GGGGAAGCGCGAGGTGCCTGA	0.587													4	35					0	0	0	0	A	57741450	A	A	57741450	3	1	130	1	0	0	0	0	1	0	0	0	2781	1059	37	1	959	1	CCDC135	16	57741450	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	186390	57741450	32613303	249	23481											
KCTD19	146212	broad.mit.edu	37	chr16	67328549	67328549	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcaccacatgcagcctcctGatggaaaaagcttcttcatt	11	11	7	12	0	3	1	2	1	1	0	4	2	4	2	3	1	3	2	3	1	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:67328549G>C	uc002esu.2	-	11	1575	c.1524C>G	c.(1522-1524)ATC>ATG	p.I508M	KCTD19_uc002est.2_Missense_Mutation_p.I280M|KCTD19_uc010vjj.1_Missense_Mutation_p.I251M	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	508						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GCAGCCTCCTGATGGAAAAAG	0.488													3	128					0	0	0	0	C	67328549	C	C	67328549	3	2	130	1	0	0	0	0	1	0	0	0	8145	1280	45	2	1280	2	KCTD19	16	67328549	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	9587099	67328549	23026204	250	23482											
SLC12A4	6560	broad.mit.edu	37	chr16	67985892	67985892	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actacagctgtcttggcacaGatgtcaaactggtcccggga	10	9	11	11	1	2	1	1	0	1	1	3	2	3	2	1	3	3	2	1	3	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:67985892G>C	uc002euz.2	-	8	1107	c.966C>G	c.(964-966)ATC>ATG	p.I322M	SLC12A4_uc010ceu.2_Missense_Mutation_p.I316M|SLC12A4_uc010vkh.1_Missense_Mutation_p.I291M|SLC12A4_uc010vki.1_Missense_Mutation_p.I322M|SLC12A4_uc010vkj.1_Missense_Mutation_p.I324M|SLC12A4_uc002eva.2_Missense_Mutation_p.I322M|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	322					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCTTGGCACAGATGTCAAACT	0.587													4	28					0	0	0	0	C	67985892	C	C	67985892	3	2	130	1	0	0	0	0	1	0	0	0	14450	932	33	2	2359	2	SLC12A4	16	67985892	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	657343	67985892	22368861	251	23483											
KIAA0174	9798	broad.mit.edu	37	chr16	71961649	71961649	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctgctggtgccagcacctCagcatctgaagacattgact	10	10	9	12	0	3	3	1	2	2	1	3	3	3	3	2	1	4	3	2	1	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:71961649C>G	uc002fbj.1	+	12	1356	c.1073C>G	c.(1072-1074)TCA>TGA	p.S358*	KIAA0174_uc010cgh.1_Nonsense_Mutation_p.S358*|KIAA0174_uc002fbk.1_Missense_Mutation_p.Q344E|KIAA0174_uc002fbm.1_Nonsense_Mutation_p.S345*|KIAA0174_uc002fbl.1_Nonsense_Mutation_p.S314*|KIAA0174_uc002fbn.1_Nonsense_Mutation_p.S197*|KIAA0174_uc010cgi.1_Nonsense_Mutation_p.S116*|KIAA0174_uc010cgj.1_Nonsense_Mutation_p.S262*|KIAA0174_uc010vml.1_RNA			P53990	IST1_HUMAN	SubName: Full=cDNA FLJ32696 fis, clone TESTI2000358; SubName: Full=cDNA FLJ77725;	343	Interaction with VTA1.				cell cycle|cell division	cytoplasmic membrane-bounded vesicle|ER-Golgi intermediate compartment	protein binding			ovary(1)	1						GCCAGCACCTCAGCATCTGAA	0.463													10	253					0	0	0	0	G	71961649	G	G	71961649	4	3	130	1	0	0	0	0	0	1	0	0	8197	827	29	2	1064	2	KIAA0174	16	71961649	Nonsense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	3975757	71961649	18393104	252	23484											
DHODH	1723	broad.mit.edu	37	chr16	72057137	72057137	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctccagggtgccctgcgctCtgaaacaggagggctgagtg	7	7	15	12	1	1	2	0	2	1	0	2	3	2	3	3	3	3	2	3	3	1	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:72057137C>G	uc002fbp.2	+	7	914	c.893C>G	c.(892-894)TCT>TGT	p.S298C	DHODH_uc010cgk.2_RNA	NM_001361	NP_001352	Q02127	PYRD_HUMAN	dihydroorotate dehydrogenase precursor	298	Mitochondrial intermembrane (By similarity).				'de novo' pyrimidine base biosynthetic process|pyrimidine nucleoside biosynthetic process|UMP biosynthetic process	integral to membrane|mitochondrial inner membrane	dihydroorotate oxidase activity				0		Ovarian(137;0.125)			Atovaquone(DB01117)|Leflunomide(DB01097)	GCCCTGCGCTCTGAAACAGGA	0.562													8	51					0	0	0	0	G	72057137	G	G	72057137	3	3	130	1	0	0	0	0	1	0	0	0	4506	913	32	2	919	2	DHODH	16	72057137	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	95488	72057137	18297616	253	23485											
TXNL4B	54957	broad.mit.edu	37	chr16	72124582	72124582	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgagaaccaacaccttctCagcagtactttttatcgcct	10	12	5	14	1	1	1	1	1	1	1	3	2	1	1	4	0	4	2	4	0	4	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:72124582C>G	uc002fca.2	-	2	378	c.67G>C	c.(67-69)GAG>CAG	p.E23Q	TXNL4B_uc010cgl.2_RNA|TXNL4B_uc010vmn.1_Missense_Mutation_p.E23Q|TXNL4B_uc010vmo.1_Missense_Mutation_p.E23Q	NM_017853	NP_060323	Q9NX01	TXN4B_HUMAN	thioredoxin-like 4B	23					mitosis|mRNA processing|RNA splicing	spliceosomal complex				ovary(1)	1						AACACCTTCTCAGCAGTACTT	0.398													10	61					0	0	0	0	G	72124582	G	G	72124582	3	3	130	1	0	0	0	0	1	0	0	0	16874	835	29	2	394	2	TXNL4B	16	72124582	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	67445	72124582	18230171	254	23486											
CNTNAP4	85445	broad.mit.edu	37	chr16	76572114	76572114	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccacgctgcttcatttcatGgtgatatgaagctgagcaga	10	11	10	10	1	2	4	2	3	0	1	2	4	2	4	1	1	3	4	1	1	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr16:76572114G>A	uc002feu.1	+	21	3482	c.3097G>A	c.(3097-3099)GGT>AGT	p.G1033S	CNTNAP4_uc002fev.1_Missense_Mutation_p.G897S|CNTNAP4_uc010chb.1_Missense_Mutation_p.G960S|CNTNAP4_uc002fex.1_Missense_Mutation_p.G1036S	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1033	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TTCATTTCATGGTGATATGAA	0.373													9	84					0	0	0	0	A	76572114	A	A	76572114	3	1	130	1	0	0	0	0	1	0	0	0	3664	1348	47	4	3184	4	CNTNAP4	16	76572114	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	4447532	76572114	13782639	255	23487											
ZNF232	7775	broad.mit.edu	37	chr17	5012863	5012863	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcgtgtgtttctctggcctCagccactcacagcagagtac	7	12	9	13	1	3	1	2	0	1	1	5	1	3	1	2	1	3	3	2	1	1	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:5012863C>T	uc002gas.2	-	3	997	c.243G>A	c.(241-243)CTG>CTA	p.L81L	ZNF232_uc002gar.1_Silent_p.L108L|ZNF232_uc002gat.2_Silent_p.L108L|ZNF232_uc010vsv.1_Silent_p.L108L	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	81	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TCTCTGGCCTCAGCCACTCAC	0.582													16	53					0	0	0	0	T	5012863	T	T	5012863	2	4	130	1	0	0	0	0	0	0	0	1	17852	813	29	2		2	ZNF232	17	5012863	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08		5012863	76182347	256	23488											
GPS2	2874	broad.mit.edu	37	chr17	7216603	7216603	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gacagggcaccaccaggctgGaggaaacctaggtggggaag	12	3	17	9	0	0	0	0	0	0	0	0	4	0	3	3	7	1	2	3	7	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:7216603G>C	uc002gfv.1	-	8	995	c.732C>G	c.(730-732)CTC>CTG	p.L244L	GPS2_uc002gfw.1_Silent_p.L206L|GPS2_uc002gfx.1_Silent_p.L244L|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_Silent_p.L244L	NM_004489	NP_004480	Q13227	GPS2_HUMAN	G protein pathway suppressor 2	244					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			ovary(2)|pancreas(1)	3		Prostate(122;0.157)				CACCAGGCTGGAGGAAACCTA	0.557											OREG0024133	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	73					0	0	0	0	C	7216603	C	C	7216603	2	2	130	1	0	0	0	0	0	0	0	1	6772	1161	41	2		2	GPS2	17	7216603	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2203740	7216603	73978607	257	23489											
TP53	7157	broad.mit.edu	37	chr17	7578263	7578263	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgcaaatttccttccactcGgataagatgctgaggagggg	11	9	12	9	2	0	2	0	1	0	1	3	4	2	4	2	4	1	2	2	4	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:7578263G>A	uc002gim.2	-	6	780	c.586C>T	c.(586-588)CGA>TGA	p.R196*	TP53_uc002gig.1_Nonsense_Mutation_p.R196*|TP53_uc002gih.2_Nonsense_Mutation_p.R196*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R64*|TP53_uc010cng.1_Nonsense_Mutation_p.R64*|TP53_uc002gii.1_Nonsense_Mutation_p.R64*|TP53_uc010cnh.1_Nonsense_Mutation_p.R196*|TP53_uc010cni.1_Nonsense_Mutation_p.R196*|TP53_uc002gij.2_Nonsense_Mutation_p.R196*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R103*|TP53_uc002gio.2_Nonsense_Mutation_p.R64*|TP53_uc010vug.1_Nonsense_Mutation_p.R157*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(125)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.R196L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R64*(1)|p.I195fs*12(1)|p.R103*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	24					0	0	0	0	A	7578263	A	A	7578263	4	1	130	1	0	0	0	0	0	1	0	0	16448	1124	39	1	708	1	TP53	17	7578263	Nonsense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	361660	7578263	73616947	258	23490											
CHD3	1107	broad.mit.edu	37	chr17	7810759	7810759	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgaggtgccaggggtgcctgGagagatggagcctgaacctg	8	7	18	8	0	0	3	0	2	0	1	0	6	0	5	4	5	4	0	4	5	1	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:7810759G>C	uc002gje.2	+	32	5027	c.4877G>C	c.(4876-4878)GGA>GCA	p.G1626A	CHD3_uc002gjd.2_Missense_Mutation_p.G1685A|CHD3_uc002gjf.2_Missense_Mutation_p.G1626A|CHD3_uc002gjh.2_Missense_Mutation_p.G202A|CHD3_uc002gjj.2_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1626	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GGGGTGCCTGGAGAGATGGAG	0.592													3	27					0	0	0	0	C	7810759	C	C	7810759	3	2	130	1	0	0	0	0	1	0	0	0	3341	1174	41	2	5284	2	CHD3	17	7810759	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	232496	7810759	73384451	259	23491											
TMEM107	84314	broad.mit.edu	37	chr17	8077524	8077524	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccgtcatgaaggtaatcaGaagggtttctttttcagccc	9	13	9	10	1	4	2	3	1	1	1	5	2	5	2	2	2	1	2	2	2	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:8077524G>C	uc002gkg.3	-	5	530	c.420C>G	c.(418-420)TTC>TTG	p.F140L	TMEM107_uc002gkh.3_Missense_Mutation_p.F146L|TMEM107_uc002gki.3_Missense_Mutation_p.F139L|TMEM107_uc002gkj.3_RNA|TMEM107_uc002gkk.2_3'UTR	NM_183065	NP_898888	Q6UX40	TM107_HUMAN	transmembrane protein 107 isoform 2	140						integral to membrane					0						AAGGTAATCAGAAGGGTTTCT	0.502													10	66					0	0	0	0	C	8077524	C	C	8077524	3	2	130	1	0	0	0	0	1	0	0	0	16089	933	33	2	6	2	TMEM107	17	8077524	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	266765	8077524	73117686	260	23492											
PFAS	5198	broad.mit.edu	37	chr17	8157504	8157504	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaggccctccccagtgctGaggagacaaagaagctgatg	11	6	13	11	0	0	5	0	3	0	2	1	6	1	5	3	2	2	2	3	2	2	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:8157504G>A	uc002gkr.2	+	3	304	c.163G>A	c.(163-165)GAG>AAG	p.E55K	PFAS_uc010vuv.1_5'UTR	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	55					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCCCAGTGCTGAGGAGACAAA	0.587													7	47					0	0	0	0	A	8157504	A	A	8157504	3	1	130	1	0	0	0	0	1	0	0	0	11809	1291	45	2	169	2	PFAS	17	8157504	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	79980	8157504	73037706	261	23493											
MYOCD	93649	broad.mit.edu	37	chr17	12656083	12656083	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccagtccacgtgtgcaCggaggaaagtctcatgagca	10	7	12	12	2	1	1	1	1	1	0	4	3	3	3	3	2	2	2	3	2	1	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:12656083C>T	uc002gnn.2	+	10	1777	c.1478C>T	c.(1477-1479)ACG>ATG	p.T493M	MYOCD_uc002gno.2_Missense_Mutation_p.T493M|MYOCD_uc002gnp.1_Missense_Mutation_p.T397M|MYOCD_uc002gnq.2_Missense_Mutation_p.T212M	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	493	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CACGTGTGCACGGAGGAAAGT	0.612													8	19					0	0	0	0	T	12656083	T	T	12656083	3	4	130	1	0	0	0	0	1	0	0	0	10140	536	19	1	1516	1	MYOCD	17	12656083	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	4498579	12656083	68539127	262	23494											
SLC6A4	6532	broad.mit.edu	37	chr17	28530257	28530257	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggatgcaaatgaaagatGaggttcctatgcagtaaccc	13	9	12	7	0	0	3	0	2	0	1	1	4	1	4	2	3	3	4	2	3	4	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:28530257G>T	uc002hey.3	-	14	2295	c.1751C>A	c.(1750-1752)TCA>TAA	p.S584*	SLC6A4_uc010csg.2_RNA	NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	584	Helical; Name=12; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	AATGAAAGATGAGGTTCCTAT	0.398													9	100					3.07112e-06	3.28111e-06	1	0	T	28530257	T	T	28530257	4	4	130	1	0	0	0	0	0	1	0	0	14750	1294	45	2	149	2	SLC6A4	17	28530257	Nonsense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	15874174	28530257	52664953	263	23495											
TNS4	84951	broad.mit.edu	37	chr17	38633892	38633892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaccaggccgatgacctgcGaggctggctggaccatgtca	8	7	13	13	2	2	1	2	1	0	0	2	4	2	2	4	4	1	2	4	4	0	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:38633892G>A	uc010cxb.2	-	13	2260	c.2096C>T	c.(2095-2097)TCG>TTG	p.S699L	TNS4_uc002huu.3_Missense_Mutation_p.S112L	NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	699	Phosphatase tensin-type.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GATGACCTGCGAGGCTGGCTG	0.587													9	72					0	0	0	0	A	38633892	A	A	38633892	3	1	130	1	0	0	0	0	1	0	0	0	16411	1059	37	1	55	1	TNS4	17	38633892	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	10103635	38633892	42561318	264	23496											
KRT12	3859	broad.mit.edu	37	chr17	39019596	39019596	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtcctccagggatttcttCtgcacgtgggagggaaatgg	8	10	15	8	1	2	0	0	0	2	0	4	4	4	3	2	4	1	1	2	4	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:39019596C>T	uc002hvk.2	-	6	1120	c.1096_splice	c.e6-1	p.K366_splice		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12						visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GGGATTTCTTCTGCACGTGGG	0.552													3	12					0	0	0	0	T	39019596	T	T	39019596	5	4	130	1	0	0	0	0	0	0	1	0	8488	927	32	2	401	2	KRT12	17	39019596	Splice_Site	SNP	C	TCGA-CR-6484-01A-11D-1870-08	385704	39019596	42175614	265	23497											
IMP5	162540	broad.mit.edu	37	chr17	43924109	43924109	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgcccacttggatcctaatGagctgcccttcatcccccct	7	10	6	18	1	1	1	1	1	0	0	3	2	3	2	6	1	2	1	6	1	1	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:43924109G>A	uc010wka.1	+	1	1837	c.1837G>A	c.(1837-1839)GAG>AAG	p.E613K	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	613	Extracellular (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		GGATCCTAATGAGCTGCCCTT	0.592													13	44					0	0	0	0	A	43924109	A	A	43924109	3	1	130	1	0	0	0	0	1	0	0	0	7760	1291	45	2	1839	2	IMP5	17	43924109	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	4904513	43924109	37271101	266	23498											
HELZ	9931	broad.mit.edu	37	chr17	65083187	65083187	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaagggccgaccaggtcctCtgggctcatactacacaaag	12	6	10	13	1	2	0	1	0	1	0	3	1	3	0	3	3	2	1	3	3	4	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:65083187C>G	uc010wqk.1	-	32	5442	c.5255G>C	c.(5254-5256)AGA>ACA	p.R1752T	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.R1751T	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					ACCAGGTCCTCTGGGCTCATA	0.428													8	36					0	0	0	0	G	65083187	G	G	65083187	3	3	130	1	0	0	0	0	1	0	0	0	7088	913	32	2	584	2	HELZ	17	65083187	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	21159078	65083187	16112023	267	23499											
CANT1	124583	broad.mit.edu	37	chr17	76989755	76989755	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgctgtcctcctcggatttGagggccacaatgatctggtc	6	11	11	13	2	1	2	0	2	1	0	5	3	3	3	4	3	0	1	4	3	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr17:76989755G>C	uc002jwn.2	-	6	1522	c.1083C>G	c.(1081-1083)CTC>CTG	p.L361L	CANT1_uc002jwk.2_Silent_p.L361L|CANT1_uc002jwj.2_Silent_p.L361L|CANT1_uc002jwl.2_Intron|CANT1_uc002jwm.1_RNA	NM_001159772	NP_001153244	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	361	Lumenal (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity				0			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			CCTCGGATTTGAGGGCCACAA	0.607			T	ETV4	prostate						OREG0024788	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	55					0	0	0	0	C	76989755	C	C	76989755	2	2	130	1	0	0	0	0	0	0	0	1	2629	1277	45	2		2	CANT1	17	76989755	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	11906568	76989755	4205455	268	23500											
SMAD2	4087	broad.mit.edu	37	chr18	45374862	45374862	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacctatatgccttcttgtCatttctaccgtggcatttcg	7	17	6	11	2	3	0	1	0	2	0	4	0	3	0	3	1	3	1	3	1	4	8			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr18:45374862C>G	uc002lcy.2	-	8	1229	c.981G>C	c.(979-981)ATG>ATC	p.M327I	SMAD2_uc002lcz.2_Missense_Mutation_p.M327I|SMAD2_uc010xdc.1_Missense_Mutation_p.M297I|SMAD2_uc010xdd.1_Missense_Mutation_p.M297I	NM_005901	NP_005892	Q15796	SMAD2_HUMAN	Sma- and Mad-related protein 2 isoform 1	327	MH2.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			large_intestine(3)|lung(1)|central_nervous_system(1)	5						GCCTTCTTGTCATTTCTACCG	0.398													7	64					0	0	0	0	G	45374862	G	G	45374862	3	3	130	1	0	0	0	0	1	0	0	0	14822	826	29	2	438	2	SMAD2	18	45374862	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08		45374862	32702386	269	23501											
RPS15	6209	broad.mit.edu	37	chr19	1440120	1440120	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcgcctgcgcaaggccaaGaaggaggcgccgcccatgga	11	2	15	13	4	0	1	0	0	0	1	0	3	0	3	4	4	2	1	4	4	4	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:1440120G>C	uc002lsp.1	+	3	254	c.192G>C	c.(190-192)AAG>AAC	p.K64N	RPS15_uc002lsq.1_Missense_Mutation_p.K71N	NM_001018	NP_001009	P62841	RS15_HUMAN	ribosomal protein S15	64					endocrine pancreas development|ribosomal small subunit export from nucleus|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleoplasm	DNA binding|protein binding|RNA binding				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAAGGCCAAGAAGGAGGCGC	0.662													3	17					0	0	0	0	C	1440120	C	C	1440120	3	2	130	1	0	0	0	0	1	0	0	0	13690	933	33	2	202	2	RPS15	19	1440120	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08		1440120	57688863	270	23502											
LMNB2	84823	broad.mit.edu	37	chr19	2444431	2444431	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctcgtccaactctgccctCagcttcccaatctctatctg	7	12	4	18	1	4	0	1	0	3	0	8	0	6	0	4	0	3	1	4	0	3	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:2444431C>G	uc002lvy.2	-	2	399	c.312G>C	c.(310-312)CTG>CTC	p.L104L	LMNB2_uc002lwa.1_Silent_p.L124L	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	104	Rod.|Coil 1B.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTCTGCCCTCAGCTTCCCAA	0.652													6	41					0	0	0	0	G	2444431	G	G	2444431	2	3	130	1	0	0	0	0	0	0	0	1	8892	813	29	2		2	LMNB2	19	2444431	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1004311	2444431	56684552	271	23503											
LRG1	116844	broad.mit.edu	37	chr19	4538721	4538721	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgcaattcttggagcttaGaggcgccctggaggaggttg	7	10	17	7	1	1	1	0	0	1	1	1	4	1	4	1	6	2	3	1	6	2	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:4538721G>C	uc002mau.2	-	2	286	c.275C>G	c.(274-276)TCT>TGT	p.S92C	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	92						extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGGAGCTTAGAGGCGCCCTG	0.627													6	29					0	0	0	0	C	4538721	C	C	4538721	3	2	130	1	0	0	0	0	1	0	0	0	8992	942	33	2	772	2	LRG1	19	4538721	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2094290	4538721	54590262	272	23504											
COL5A3	50509	broad.mit.edu	37	chr19	10080263	10080263	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccactcaccacagggccaggGatccctcgaagaccctcagg	10	4	10	17	1	2	1	2	0	0	1	4	3	3	2	5	3	0	0	5	3	1	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:10080263G>A	uc002mmq.1	-	56	4172	c.4086C>T	c.(4084-4086)ATC>ATT	p.I1362I		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1362	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CAGGGCCAGGGATCCCTCGAA	0.672													3	23					0	0	0	0	A	10080263	A	A	10080263	2	1	130	1	0	0	0	0	0	0	0	1	3713	1164	41	2		2	COL5A3	19	10080263	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	5541542	10080263	49048720	273	23505											
DOCK6	57572	broad.mit.edu	37	chr19	11333759	11333759	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaaagccaggctggcgttGaggtgctcggccagctccac	9	6	14	12	2	0	2	0	1	0	1	2	2	1	2	3	4	3	4	3	4	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:11333759G>C	uc002mqs.3	-	25	3020	c.2979C>G	c.(2977-2979)CTC>CTG	p.L993L	DOCK6_uc010xlq.1_Silent_p.L332L	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	993					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GGCTGGCGTTGAGGTGCTCGG	0.617													6	74					0	0	0	0	C	11333759	C	C	11333759	2	2	130	1	0	0	0	0	0	0	0	1	4713	1277	45	2		2	DOCK6	19	11333759	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1253496	11333759	47795224	274	23506											
DNAJB1	3337	broad.mit.edu	37	chr19	14627500	14627500	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgctctttccgtcggggttTagccgcttgtgggagatttt	4	16	13	8	3	1	1	0	0	1	1	3	2	2	1	2	3	2	3	2	3	1	6	rs143985567	byFrequency	TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:14627500T>C	uc002myz.1	-	2	610	c.570A>G	c.(568-570)CTA>CTG	p.L190L	DNAJB1_uc010xnr.1_Silent_p.L90L	NM_006145	NP_006136	P25685	DNJB1_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 1	190					chaperone cofactor-dependent protein refolding|response to unfolded protein	cytoplasm|nucleolus	heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(1328;0.0476)		CGTCGGGGTTTAGCCGCTTGT	0.483													4	302					0	0	0	0	C	14627500	C	C	14627500	2	2	130	1	0	0	0	0	0	0	0	1	4637	1741	61	5		5	DNAJB1	19	14627500	Silent	SNP	T	TCGA-CR-6484-01A-11D-1870-08	3293741	14627500	44501483	275	23507											
C19orf44	84167	broad.mit.edu	37	chr19	16614078	16614078	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccatcacaggcgccttttCaaactcagtgtctttaaaga	11	13	6	11	1	4	1	3	0	1	1	5	1	5	1	2	1	1	0	2	1	3	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:16614078C>G	uc002neh.1	+	3	1035	c.962C>G	c.(961-963)TCA>TGA	p.S321*	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Nonsense_Mutation_p.S321*|C19orf44_uc002neg.2_Nonsense_Mutation_p.S321*|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	321											0						GGCGCCTTTTCAAACTCAGTG	0.552													12	111					0	0	0	0	G	16614078	G	G	16614078	4	3	130	1	0	0	0	0	0	1	0	0	1936	838	29	2	968	2	C19orf44	19	16614078	Nonsense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1986578	16614078	42514905	276	23508											
NXNL1	115861	broad.mit.edu	37	chr19	17571473	17571473	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagggccagctgagccgccCgcagtacatagaactcatct	10	6	10	15	2	2	2	1	1	1	1	2	2	2	2	4	1	4	3	4	1	3	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:17571473C>T	uc002ngs.2	-	1	253	c.206G>A	c.(205-207)CGG>CAG	p.R69Q		NM_138454	NP_612463	Q96CM4	NXNL1_HUMAN	nucleoredoxin-like 1	69	Thioredoxin.				cell redox homeostasis	nuclear outer membrane					0						CTGAGCCGCCCGCAGTACATA	0.587													15	59					0	0	0	0	T	17571473	T	T	17571473	3	4	130	1	0	0	0	0	1	0	0	0	10842	652	23	1	440	1	NXNL1	19	17571473	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	957395	17571473	41557510	277	23509											
UPF1	5976	broad.mit.edu	37	chr19	18943117	18943117	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gacacacagggctccgagttCgagttcaccgactttactct	9	10	9	13	3	2	0	1	0	1	0	4	4	3	0	2	1	1	3	2	1	1	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:18943117C>G	uc002nkg.2	+	1	374	c.99C>G	c.(97-99)TTC>TTG	p.F33L	UPF1_uc002nkf.2_Missense_Mutation_p.F33L	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	33	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GCTCCGAGTTCGAGTTCACCG	0.428													21	69					0	0	0	0	G	18943117	G	G	18943117	3	3	130	1	0	0	0	0	1	0	0	0	17071	883	31	3	101	3	UPF1	19	18943117	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1371644	18943117	40185866	278	23510											
ZNF90	7643	broad.mit.edu	37	chr19	20229332	20229332	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaatgtggcaaagccttcaaGctctcctcaatccttagtac	11	11	7	12	0	3	0	2	0	1	0	5	1	4	0	3	1	3	3	3	1	6	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:20229332G>A	uc002nor.2	+	4	1108	c.969G>A	c.(967-969)AAG>AAA	p.K323K	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	323	C2H2-type 6.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AAGCCTTCAAGCTCTCCTCAA	0.418													5	36					0	0	0	0	A	20229332	A	A	20229332	2	1	130	1	0	0	0	0	0	0	0	1	18266	962	34	4		4	ZNF90	19	20229332	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1286215	20229332	38899651	279	23511											
ZNF429	353088	broad.mit.edu	37	chr19	21720644	21720644	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaaccctacaaatgtgaaGaatgtggcaaagcttttaat	17	10	8	6	0	0	3	0	1	0	2	0	3	0	3	1	1	3	2	1	1	7	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:21720644G>C	uc002nqd.1	+	4	1926	c.1789G>C	c.(1789-1791)GAA>CAA	p.E597Q	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	597	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CAAATGTGAAGAATGTGGCAA	0.358													6	58					0	0	0	0	C	21720644	C	C	21720644	3	2	130	1	0	0	0	0	1	0	0	0	17969	943	33	2	1803	2	ZNF429	19	21720644	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1491312	21720644	37408339	280	23512											
ZNF681	148213	broad.mit.edu	37	chr19	23927132	23927132	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttatgtctagtaaggtgtGaggacttgttaaaagctttg	10	16	11	4	0	2	1	0	1	2	0	2	2	2	2	0	2	1	3	0	2	5	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:23927132G>C	uc002nrk.3	-	4	1362	c.1220C>G	c.(1219-1221)TCA>TGA	p.S407*	ZNF681_uc002nrl.3_Nonsense_Mutation_p.S338*|ZNF681_uc002nrj.3_Nonsense_Mutation_p.S338*	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	407	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				AGTAAGGTGTGAGGACTTGTT	0.398													8	71					0	0	0	0	C	23927132	C	C	23927132	4	2	130	1	0	0	0	0	0	1	0	0	18155	1294	45	2	721	2	ZNF681	19	23927132	Nonsense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2206488	23927132	35201851	281	23513											
ZNF536	9745	broad.mit.edu	37	chr19	31039498	31039498	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgcctccctcccgggctcctCggtaactgtgcaggacagca	6	7	11	17	3	0	0	0	0	0	0	4	1	3	1	4	3	3	4	4	3	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:31039498C>G	uc002nsu.1	+	4	3110	c.2972C>G	c.(2971-2973)TCG>TGG	p.S991W	ZNF536_uc010edd.1_Missense_Mutation_p.S991W	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	991					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCGGGCTCCTCGGTAACTGTG	0.577													10	68					0	0	0	0	G	31039498	G	G	31039498	3	3	130	1	0	0	0	0	1	0	0	0	18041	893	31	3	2982	3	ZNF536	19	31039498	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	7112366	31039498	28089485	282	23514											
GPATCH1	55094	broad.mit.edu	37	chr19	33592477	33592477	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctaaacctttatcttctaaGaaagtaagaaaaactttttt	16	16	3	6	0	3	2	0	0	3	2	3	2	3	2	1	0	2	1	1	0	8	9			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:33592477G>C	uc002nug.1	+	9	1391	c.1077G>C	c.(1075-1077)AAG>AAC	p.K359N		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	359						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					TATCTTCTAAGAAAGTAAGAA	0.303													9	48					0	0	0	0	C	33592477	C	C	33592477	3	2	130	1	0	0	0	0	1	0	0	0	6628	933	33	2	1111	2	GPATCH1	19	33592477	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2552979	33592477	25536506	283	23515											
PDCD2L	84306	broad.mit.edu	37	chr19	34912556	34912556	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagcactggtcagcatgctCaagagtgctaatttaggtga	11	10	11	9	0	2	2	2	1	0	1	2	2	2	2	1	2	4	4	1	2	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:34912556C>G	uc002nvj.2	+	6	963	c.930C>G	c.(928-930)CTC>CTG	p.L310L		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	310						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			TCAGCATGCTCAAGAGTGCTA	0.408													13	102					0	0	0	0	G	34912556	G	G	34912556	2	3	130	1	0	0	0	0	0	0	0	1	11674	813	29	2		2	PDCD2L	19	34912556	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1320079	34912556	24216427	284	23516											
WDR62	284403	broad.mit.edu	37	chr19	36594781	36594781	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttcgcccaagtctcccagctCctgagtcccctggccttcct	4	11	7	19	1	1	1	0	1	1	0	6	1	4	1	7	1	1	1	7	1	1	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:36594781C>G	uc002odc.2	+	30	4127	c.4036C>G	c.(4036-4038)CCT>GCT	p.P1346A	WDR62_uc002odd.2_Missense_Mutation_p.P1351A	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	1346					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TCTCCCAGCTCCTGAGTCCCC	0.687													8	60					0	0	0	0	G	36594781	G	G	36594781	3	3	130	1	0	0	0	0	1	0	0	0	17381	855	30	2	4169	2	WDR62	19	36594781	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1682225	36594781	22534202	285	23517											
ZNF574	64763	broad.mit.edu	37	chr19	42584276	42584276	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtggcaagatgttcaagaaGaagtctcacgtgcgtaacca	13	9	11	8	2	2	3	2	0	1	3	3	3	2	3	1	1	2	3	1	1	5	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:42584276G>C	uc002osm.3	+	2	1687	c.1518G>C	c.(1516-1518)AAG>AAC	p.K506N	ZNF574_uc002osk.3_Missense_Mutation_p.K596N	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	506	C2H2-type 10; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				TGTTCAAGAAGAAGTCTCACG	0.582													32	222					0	0	0	0	C	42584276	C	C	42584276	3	2	130	1	0	0	0	0	1	0	0	0	18073	933	33	2	1520	2	ZNF574	19	42584276	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	5989495	42584276	16544707	286	23518											
CIC	23152	broad.mit.edu	37	chr19	42797308	42797308	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccccagagtctgagcttGaggggcagcccacaccacca	9	5	11	16	0	1	3	0	2	1	1	1	3	1	3	5	2	3	2	5	2	0	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:42797308G>C	uc002otf.1	+	15	3710	c.3670G>C	c.(3670-3672)GAG>CAG	p.E1224Q		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	1224	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				GTCTGAGCTTGAGGGGCAGCC	0.716			T	DUX4	soft tissue sarcoma								3	15					0	0	0	0	C	42797308	C	C	42797308	3	2	130	1	0	0	0	0	1	0	0	0	3439	1291	45	2	3728	2	CIC	19	42797308	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	213032	42797308	16331675	287	23519											
ZC3H4	23211	broad.mit.edu	37	chr19	47570821	47570821	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctggaatgaaggctgccttCgggcttggaggtgggcaggg	6	8	20	7	1	0	1	0	1	0	0	1	3	0	3	1	7	1	4	1	7	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:47570821C>T	uc002pga.3	-	15	2742	c.2704G>A	c.(2704-2706)GAA>AAA	p.E902K	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	902							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		AGGCTGCCTTCGGGCTTGGAG	0.697													5	22					0	0	0	0	T	47570821	T	T	47570821	3	4	130	1	0	0	0	0	1	0	0	0	17637	893	31	1	1211	1	ZC3H4	19	47570821	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	4773513	47570821	11558162	288	23520											
PRR12	57479	broad.mit.edu	37	chr19	50099779	50099779	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggaggctgaaggagaagaaGaaagggccagagcggggtgg	13	2	22	4	1	0	5	0	1	0	4	0	7	0	6	1	7	1	1	1	7	4	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:50099779G>C	uc002poo.3	+	4	2187	c.2187G>C	c.(2185-2187)AAG>AAC	p.K729N		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		AGGAGAAGAAGAAAGGGCCAG	0.652													5	15					0	0	0	0	C	50099779	C	C	50099779	3	2	130	1	0	0	0	0	1	0	0	0	12646	933	33	2	2201	2	PRR12	19	50099779	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2528958	50099779	9029204	289	23521											
IL4I1	259307	broad.mit.edu	37	chr19	50394716	50394716	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctgcagcccagtgccttGaggtctttgagggcctgttg	4	14	13	10	0	2	2	0	2	2	0	2	2	2	2	3	2	3	2	3	2	0	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:50394716G>C	uc002pqt.1	-	6	660	c.582C>G	c.(580-582)CTC>CTG	p.L194L	IL4I1_uc002pqv.1_Silent_p.L203L|IL4I1_uc010eno.1_Silent_p.L202L|IL4I1_uc002pqw.1_Silent_p.L202L|IL4I1_uc002pqu.1_Silent_p.L216L	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	194						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		CCAGTGCCTTGAGGTCTTTGA	0.532													17	116					0	0	0	0	C	50394716	C	C	50394716	2	2	130	1	0	0	0	0	0	0	0	1	7736	1277	45	2		2	IL4I1	19	50394716	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	294937	50394716	8734267	290	23522											
POLD1	5424	broad.mit.edu	37	chr19	50902122	50902122	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcaggatggatggcaagcGgcggccaggcccagggcccg	8	2	18	13	3	0	0	0	0	0	0	0	2	0	2	3	7	2	2	3	7	1	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:50902122G>A	uc002psb.3	+	2	70	c.14G>A	c.(13-15)CGG>CAG	p.R5Q	POLD1_uc002psc.3_Missense_Mutation_p.R5Q|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.R5Q	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	5	Nuclear localization signal (Potential).				base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		GATGGCAAGCGGCGGCCAGGC	0.647								DNA_polymerases_(catalytic_subunits)					9	16					0	0	0	0	A	50902122	A	A	50902122	3	1	130	1	0	0	0	0	1	0	0	0	12245	1116	39	1	16	1	POLD1	19	50902122	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	507406	50902122	8226861	291	23523											
ZNF614	80110	broad.mit.edu	37	chr19	52519444	52519444	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catctctcatgttgtatgagGcatattttctggctgaaggc	8	15	10	8	0	3	2	1	2	2	0	4	2	3	2	0	3	0	4	0	3	3	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:52519444G>A	uc002pyj.2	-	5	1809	c.1407C>T	c.(1405-1407)TGC>TGT	p.C469C	ZNF614_uc002pyi.3_Intron|ZNF614_uc010epj.2_Silent_p.C172C	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	469	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GTTGTATGAGGCATATTTTCT	0.413													4	137					0	0	0	0	A	52519444	A	A	52519444	2	1	130	1	0	0	0	0	0	0	0	1	18106	1195	42	4		4	ZNF614	19	52519444	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1617322	52519444	6609539	292	23524											
LILRB5	10990	broad.mit.edu	37	chr19	54758764	54758764	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttgactttagacacagcggGggatgggctgccccctcctt	6	11	12	12	1	0	2	0	1	0	1	1	3	1	3	3	3	2	1	3	3	1	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:54758764G>A	uc002qex.2	-	6	1200	c.1089C>T	c.(1087-1089)CCC>CCT	p.P363P	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Silent_p.P354P|LILRB5_uc002qey.2_Silent_p.P363P|LILRB5_uc002qez.2_Silent_p.P263P|LILRB5_uc002qfa.1_Silent_p.P253P|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	363	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GACACAGCGGGGGATGGGCTG	0.547													5	53					0	0	0	0	A	54758764	A	A	54758764	2	1	130	1	0	0	0	0	0	0	0	1	8835	1219	43	4		4	LILRB5	19	54758764	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2239320	54758764	4370219	293	23525											
TMEM150B	284417	broad.mit.edu	37	chr19	55824272	55824272	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggaggccggcggggggctGaggctgggccacggctgaac	5	3	23	10	3	0	2	0	2	0	0	0	3	0	3	2	10	1	3	2	10	1	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:55824272G>A	uc010esw.1	-	8	830	c.657C>T	c.(655-657)CTC>CTT	p.L219L	TMEM150B_uc010yfu.1_Silent_p.L219L|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	219	Cytoplasmic (Potential).					integral to membrane					0						GCGGGGGGCTGAGGCTGGGCC	0.672													5	9					0	0	0	0	A	55824272	A	A	55824272	2	1	130	1	0	0	0	0	0	0	0	1	16134	1277	45	2		2	TMEM150B	19	55824272	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1065508	55824272	3304711	294	23526											
EPN1	29924	broad.mit.edu	37	chr19	56204355	56204355	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggagcccgacgagttctctGactttgaccgactccgcacg	7	8	11	15	6	1	2	0	2	1	0	3	6	2	3	3	1	1	2	3	1	0	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:56204355G>C	uc002qlw.2	+	9	1558	c.1216G>C	c.(1216-1218)GAC>CAC	p.D406H	EPN1_uc002qlv.2_Missense_Mutation_p.D380H|EPN1_uc010etd.2_Missense_Mutation_p.D405H|EPN1_uc002qlx.2_Missense_Mutation_p.D492H	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	406	[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif.|Ala/Gly/Pro-rich.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		CGAGTTCTCTGACTTTGACCG	0.701													19	121					0	0	0	0	C	56204355	C	C	56204355	3	2	130	1	0	0	0	0	1	0	0	0	5209	1290	45	2	1587	2	EPN1	19	56204355	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	380083	56204355	2924628	295	23527											
NLRP13	126204	broad.mit.edu	37	chr19	56423845	56423845	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtagtctgagtgattgaCtggagatcgtaatacctcac	10	12	12	7	1	2	4	1	3	1	1	3	5	2	4	1	2	1	2	1	2	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr19:56423845C>T	uc010ygg.1	-	5	1363	c.1338G>A	c.(1336-1338)CAG>CAA	p.Q446Q		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	446	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GAGTGATTGACTGGAGATCGT	0.478													13	108					0	0	0	0	T	56423845	T	T	56423845	2	4	130	1	0	0	0	0	0	0	0	1	10529	564	20	4		4	NLRP13	19	56423845	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	219490	56423845	2705138	296	23528											
PTPRA	5786	broad.mit.edu	37	chr20	3007774	3007774	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcttcttacagatgaattCaacagagtgatcattccagt	13	14	6	8	0	4	4	2	2	2	2	5	4	5	4	1	0	2	0	1	0	3	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr20:3007774C>G	uc010zqd.1	+	18	2066	c.1749C>G	c.(1747-1749)TTC>TTG	p.F583L	PTPRA_uc002whj.2_Missense_Mutation_p.F572L|PTPRA_uc002whk.2_Missense_Mutation_p.F563L|PTPRA_uc002whl.2_Missense_Mutation_p.F563L|PTPRA_uc002whm.2_Missense_Mutation_p.F339L|PTPRA_uc002whn.2_Missense_Mutation_p.F563L|PTPRA_uc002who.2_Missense_Mutation_p.F235L	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	572	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						CAGATGAATTCAACAGAGTGA	0.493													9	107					0	0	0	0	G	3007774	G	G	3007774	3	3	130	1	0	0	0	0	1	0	0	0	12860	825	29	2	1778	2	PTPRA	20	3007774	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08		3007774	60017746	297	23529											
RNF24	11237	broad.mit.edu	37	chr20	3944599	3944599	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaccacaatatatatgttGagaggcagattctggaatcc	16	10	8	7	0	1	2	0	1	1	2	2	4	2	3	2	2	1	2	2	2	7	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr20:3944599G>A	uc002wkh.2	-	2	336	c.66C>T	c.(64-66)CTC>CTT	p.L22L	RNF24_uc002wki.2_Silent_p.L43L|RNF24_uc002wkj.2_Silent_p.L22L	NM_007219	NP_009150	Q9Y225	RNF24_HUMAN	ring finger protein 24 isoform 1	22						Golgi membrane|integral to membrane	zinc ion binding				0						TATATATGTTGAGAGGCAGAT	0.363													7	62					0	0	0	0	A	3944599	A	A	3944599	2	1	130	1	0	0	0	0	0	0	0	1	13549	1277	45	2		2	RNF24	20	3944599	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	936825	3944599	59080921	298	23530											
RRBP1	6238	broad.mit.edu	37	chr20	17623689	17623689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgatgagccgctgggcctCgccctcgttgaacaccatgc	6	8	11	16	4	0	2	0	2	0	0	3	3	0	2	4	1	3	2	4	1	1	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr20:17623689C>T	uc002wpv.1	-	5	1051	c.697G>A	c.(697-699)GAG>AAG	p.E233K	RRBP1_uc002wpu.2_Missense_Mutation_p.E7K|RRBP1_uc002wpw.1_Missense_Mutation_p.E233K|RRBP1_uc010gcl.1_Missense_Mutation_p.E7K	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	666	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						CGCTGGGCCTCGCCCTCGTTG	0.637													8	44					0	0	0	0	T	17623689	T	T	17623689	3	4	130	1	0	0	0	0	1	0	0	0	13743	893	31	1	2324	1	RRBP1	20	17623689	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	13679090	17623689	45401831	299	23531											
RIN2	54453	broad.mit.edu	37	chr20	19981362	19981362	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtgtgtcagatctgcgctGagaagttcaaggtgggggac	9	10	16	6	1	3	2	2	1	1	2	3	4	3	3	0	3	1	2	0	3	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr20:19981362G>C	uc002wro.1	+	11	2506	c.2470G>C	c.(2470-2472)GAG>CAG	p.E824Q	RIN2_uc010gcu.1_Missense_Mutation_p.E391Q|RIN2_uc010gcv.1_Missense_Mutation_p.E618Q	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	824	Ras-associating.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						GATCTGCGCTGAGAAGTTCAA	0.517													13	118					0	0	0	0	C	19981362	C	C	19981362	3	2	130	1	0	0	0	0	1	0	0	0	13437	1291	45	2	2512	2	RIN2	20	19981362	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	2357673	19981362	43044158	300	23532											
CST9L	128821	broad.mit.edu	37	chr20	23546668	23546668	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcaatgtcgtcttcaaatttCccacacctagttctccccag	9	13	4	15	1	4	0	2	0	2	0	7	0	5	0	4	0	0	1	4	0	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr20:23546668C>G	uc002wtk.3	-	2	596	c.297G>C	c.(295-297)GGG>GGC	p.G99G		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	99						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					CTTCAAATTTCCCACACCTAG	0.468													22	205					0	0	0	0	G	23546668	G	G	23546668	2	3	130	1	0	0	0	0	0	0	0	1	3997	842	30	2		2	CST9L	20	23546668	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08	3565306	23546668	39478852	301	23533											
R3HDML	140902	broad.mit.edu	37	chr20	42965898	42965898	+	Frame_Shift_Del	DEL	C	-	-																															taatgctaccccagccccggCccagcccgagagcacggcta																										TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr20:42965898delC	uc002xls.1	+	1	273	c.101delC	c.(100-102)GCCfs	p.A34fs		NM_178491	NP_848586	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like precursor	34						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CCAGCCCCGGCCCAGCCCGAG	0.647													---	---	---								-	42965898	-	-	42965898	7	5	130	1	0	1	0	1	0	0	0	0	12954	739	26	0	103	0	R3HDML	20	42965898	Frame_Shift_Del	DEL	C	TCGA-CR-6484-01A-11D-1870-08	19419230	42965898	20059622	302	23534											
CSE1L	1434	broad.mit.edu	37	chr20	47691914	47691914	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggattatgcaagttttttGagggacctgtgacaggaatc	11	12	13	5	0	0	2	0	2	0	0	1	6	0	5	1	3	1	2	1	3	3	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr20:47691914G>C	uc002xty.2	+	12	1326	c.1192G>C	c.(1192-1194)GAG>CAG	p.E398Q	CSE1L_uc010zyg.1_Missense_Mutation_p.E181Q|CSE1L_uc010ghx.2_Missense_Mutation_p.E342Q|CSE1L_uc010ghy.2_Missense_Mutation_p.E47Q|CSE1L_uc010zyh.1_Missense_Mutation_p.E47Q	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	398					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			CAAGTTTTTTGAGGGACCTGT	0.383													7	97					0	0	0	0	C	47691914	C	C	47691914	3	2	130	1	0	0	0	0	1	0	0	0	3947	1291	45	2	1234	2	CSE1L	20	47691914	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	4726016	47691914	15333606	303	23535											
SRMS	6725	broad.mit.edu	37	chr20	62172623	62172623	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgtctgacttctgggagaaGacacgataattggccgcctc	10	9	11	11	3	2	3	0	1	2	2	3	5	2	3	2	2	0	0	2	2	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr20:62172623G>C	uc002yfi.1	-	7	1247	c.1206C>G	c.(1204-1206)GTC>GTG	p.V402V		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	402	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			TCTGGGAGAAGACACGATAAT	0.617													18	160					0	0	0	0	C	62172623	C	C	62172623	2	2	130	1	0	0	0	0	0	0	0	1	15218	929	33	2		2	SRMS	20	62172623	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08	14480709	62172623	852897	304	23536											
RGS19	10287	broad.mit.edu	37	chr20	62705602	62705602	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctcctcgcaggccaaccaGaagagcatgttctcctcgct	9	8	9	15	2	1	2	0	0	1	2	5	2	2	2	4	1	3	5	4	1	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr20:62705602G>C	uc002yhy.2	-	5	624	c.357C>G	c.(355-357)TTC>TTG	p.F119L	RGS19_uc002yhz.2_Missense_Mutation_p.F97L|RGS19_uc002yia.2_Missense_Mutation_p.F119L|RGS19_uc002yib.2_Missense_Mutation_p.F119L	NM_005873	NP_005864	P49795	RGS19_HUMAN	G protein signalling regulator 19	119	RGS.				autophagy|G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|small GTPase mediated signal transduction	Golgi apparatus|membrane fraction|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			skin(1)	1	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					AGGCCAACCAGAAGAGCATGT	0.607													4	29					0	0	0	0	C	62705602	C	C	62705602	3	2	130	1	0	0	0	0	1	0	0	0	13366	933	33	2	304	2	RGS19	20	62705602	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	532979	62705602	319918	305	23537											
RNF160	26046	broad.mit.edu	37	chr21	30318479	30318479	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaagtatcacctaccaactGaaaagaaaaatatcttcatg	19	10	4	8	0	3	2	2	1	1	1	3	2	3	2	2	0	2	1	2	0	10	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr21:30318479G>A	uc002ymr.2	-	20	3769	c.3756C>T	c.(3754-3756)TTC>TTT	p.F1252F		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1206							ligase activity|zinc ion binding				0						CCTACCAACTGAAAAGAAAAA	0.308													8	106					0	0	0	0	A	30318479	A	A	30318479	2	1	130	1	0	0	0	0	0	0	0	1	13520	1281	45	2		2	RNF160	21	30318479	Silent	SNP	G	TCGA-CR-6484-01A-11D-1870-08		30318479	17811416	306	23538											
HIRA	7290	broad.mit.edu	37	chr22	19384358	19384358	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccaactgccagtccagcgtCctccacacctttaggctgcg	7	9	8	17	2	0	0	0	0	0	0	4	0	4	0	6	1	4	1	6	1	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr22:19384358C>T	uc002zpf.1	-	7	826	c.606G>A	c.(604-606)AGG>AGA	p.R202R	HIRA_uc011agx.1_Silent_p.R68R|HIRA_uc010grn.1_Silent_p.R202R|HIRA_uc010gro.1_Silent_p.R158R|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	202	WD 4.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					AGTCCAGCGTCCTCCACACCT	0.557													8	79					0	0	0	0	T	19384358	T	T	19384358	2	4	130	1	0	0	0	0	0	0	0	1	7159	854	30	2		2	HIRA	22	19384358	Silent	SNP	C	TCGA-CR-6484-01A-11D-1870-08		19384358	31920208	307	23539											
DGCR8	54487	broad.mit.edu	37	chr22	20094865	20094865	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcacccacatgtcaagAactgggggtctttactgcgc	8	10	11	12	1	2	1	1	0	1	1	2	1	2	1	1	2	5	2	1	2	3	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr22:20094865A>G	uc002zri.2	+	12	2418	c.2068A>G	c.(2068-2070)AAC>GAC	p.N690D	DGCR8_uc010grz.2_Missense_Mutation_p.N657D|DGCR8_uc002zrj.2_Missense_Mutation_p.N333D	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	690	Necessary for heme-binding and pri-miRNA processing.|Necessary for interaction with DROSHA.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					ACATGTCAAGAACTGGGGGTC	0.537													6	108					0	0	0	0	G	20094865	G	G	20094865	3	3	130	1	0	0	0	0	1	0	0	0	4486	246	9	5	2110	5	DGCR8	22	20094865	Missense_Mutation	SNP	A	TCGA-CR-6484-01A-11D-1870-08	710507	20094865	31209701	308	23540											
ZNF74	7625	broad.mit.edu	37	chr22	20755021	20755021	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtaccgggatgtgatgttgGagaactaccagaaccttctt	10	12	11	8	1	1	3	0	1	1	2	1	5	1	4	3	2	4	2	3	2	4	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr22:20755021G>C	uc010gsm.2	+	4	432	c.220G>C	c.(220-222)GAG>CAG	p.E74Q	ZNF74_uc002zsg.2_Missense_Mutation_p.E3Q|ZNF74_uc002zsh.2_Missense_Mutation_p.E74Q|ZNF74_uc002zsi.2_Missense_Mutation_p.E3Q|ZNF74_uc010gsn.2_Missense_Mutation_p.E3Q	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	74	KRAB.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TGTGATGTTGGAGAACTACCA	0.542													9	134					0	0	0	0	C	20755021	C	C	20755021	3	2	130	1	0	0	0	0	1	0	0	0	18194	1175	41	2	230	2	ZNF74	22	20755021	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	660156	20755021	30549545	309	23541											
PITPNB	23760	broad.mit.edu	37	chr22	28293876	28293876	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcctcacgaatgcaggcaCtttgctgggagaagagagat	12	8	12	9	1	1	3	1	0	0	3	2	6	2	3	1	2	2	3	1	2	2	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr22:28293876C>G	uc003adk.2	-	4	278	c.202G>C	c.(202-204)GTG>CTG	p.V68L	PITPNB_uc011akh.1_Missense_Mutation_p.V70L|PITPNB_uc003adl.2_Missense_Mutation_p.V68L	NM_012399	NP_036531	P48739	PIPNB_HUMAN	phosphatidylinositol transfer protein, beta	68					lipid metabolic process|transport	Golgi apparatus	lipid binding			skin(1)	1						AATGCAGGCACTTTGCTGGGA	0.458													11	97					0	0	0	0	G	28293876	G	G	28293876	3	3	130	1	0	0	0	0	1	0	0	0	12003	565	20	4	645	4	PITPNB	22	28293876	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	7538855	28293876	23010690	310	23542											
NF2	4771	broad.mit.edu	37	chr22	30038255	30038255	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcttctgtgctcctggcttCttacgccgtccaggccaagg	4	11	12	14	2	2	0	0	0	2	0	4	0	4	0	4	4	2	3	4	4	2	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr22:30038255C>T	uc003age.3	+	4	871	c.428C>T	c.(427-429)TCT>TTT	p.S143F	NF2_uc003afy.3_Missense_Mutation_p.S143F|NF2_uc003afz.3_Missense_Mutation_p.S60F|NF2_uc003agf.3_Missense_Mutation_p.S143F|NF2_uc003agb.3_Missense_Mutation_p.S66F|NF2_uc003agc.3_Missense_Mutation_p.S105F|NF2_uc003agd.3_RNA|NF2_uc003agg.3_Missense_Mutation_p.S143F|NF2_uc003aga.3_Missense_Mutation_p.S101F|NF2_uc003agh.3_Missense_Mutation_p.S102F|NF2_uc003agi.3_Missense_Mutation_p.S60F|NF2_uc003agj.3_Missense_Mutation_p.S143F|NF2_uc003agk.3_Missense_Mutation_p.S105F	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	143	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.V122_K149del(5)|p.Y144fs*5(1)|p.K123fs*2(1)|p.L127_D382del(1)|p.L140_P252del(1)|p.A142fs*8(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						CTCCTGGCTTCTTACGCCGTC	0.458			D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				12	97					0	0	0	0	T	30038255	T	T	30038255	3	4	130	1	0	0	0	0	1	0	0	0	10411	913	32	2	442	2	NF2	22	30038255	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1744379	30038255	21266311	311	23543											
SEC14L4	284904	broad.mit.edu	37	chr22	30891384	30891384	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagtacacagggcagccttCgtagtcgtagccacaaagac	13	6	11	11	2	0	1	0	0	0	1	2	2	0	1	2	1	3	4	2	1	5	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr22:30891384C>T	uc003aid.2	-	5	380	c.280G>A	c.(280-282)GAA>AAA	p.E94K	SEC14L4_uc011akz.1_Missense_Mutation_p.E94K|SEC14L4_uc003aie.2_Missense_Mutation_p.E79K|SEC14L4_uc003aif.2_Missense_Mutation_p.E40K	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a	94	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	GGGCAGCCTTCGTAGTCGTAG	0.562													7	42					0	0	0	0	T	30891384	T	T	30891384	3	4	130	1	0	0	0	0	1	0	0	0	14049	893	31	1	978	1	SEC14L4	22	30891384	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	853129	30891384	20413182	312	23544											
SFI1	9814	broad.mit.edu	37	chr22	31927062	31927062	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgcgtggccagaaagttCttatatttatggattcgaat	12	14	10	5	2	1	2	0	0	1	2	2	4	1	3	1	2	1	1	1	2	5	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chr22:31927062C>G	uc003ale.2	+	4	678	c.285C>G	c.(283-285)TTC>TTG	p.F95L	SFI1_uc003ald.1_Intron|SFI1_uc003alf.2_Missense_Mutation_p.F95L|SFI1_uc003alg.2_Intron|SFI1_uc011alp.1_Intron|SFI1_uc011alq.1_Intron|SFI1_uc003alh.2_Intron	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	95					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						CCAGAAAGTTCTTATATTTAT	0.358													5	85					0	0	0	0	G	31927062	G	G	31927062	3	3	130	1	0	0	0	0	1	0	0	0	14221	912	32	2	295	2	SFI1	22	31927062	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	1035678	31927062	19377504	313	23545											
NLGN4X	57502	broad.mit.edu	37	chrX	5821900	5821900	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctctgaatgatggccttctgGaagagacctgcaggtgcaaa	11	9	12	9	0	2	3	0	2	2	1	2	5	2	4	2	3	2	2	2	3	3	1			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chrX:5821900G>C	uc010ndh.2	-	5	1320	c.819C>G	c.(817-819)TTC>TTG	p.F273L	NLGN4X_uc004crp.2_Missense_Mutation_p.F293L|NLGN4X_uc004crq.2_Missense_Mutation_p.F273L|NLGN4X_uc010ndi.2_Missense_Mutation_p.F310L|NLGN4X_uc004crr.2_Missense_Mutation_p.F273L|NLGN4X_uc010ndj.2_Missense_Mutation_p.F273L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	273	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TGGCCTTCTGGAAGAGACCTG	0.527													9	66					0	0	0	0	C	5821900	C	C	5821900	3	2	130	1	0	0	0	0	1	0	0	0	10518	1165	41	2	1639	2	NLGN4X	23	5821900	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08		5821900	149448660	314	23546											
TBL1X	6907	broad.mit.edu	37	chrX	9683006	9683006	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgaggtgtgctggaacgcccGaggagacaaagtgggtgcca	10	5	17	9	3	0	1	0	0	0	1	0	5	0	2	2	4	3	1	2	4	2	0			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chrX:9683006G>A	uc010ndq.2	+	17	2038	c.1670G>A	c.(1669-1671)CGA>CAA	p.R557Q	TBL1X_uc004csq.3_Missense_Mutation_p.R506Q|TBL1X_uc010ndr.2_Missense_Mutation_p.R506Q|TBL1X_uc004csr.2_Missense_Mutation_p.R557Q|TBL1X_uc004css.2_Missense_Mutation_p.R508Q	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	557	WD 8.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				TGGAACGCCCGAGGAGACAAA	0.587													8	29					0	0	0	0	A	9683006	A	A	9683006	3	1	130	1	0	0	0	0	1	0	0	0	15705	1058	37	1	1724	1	TBL1X	23	9683006	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	3861106	9683006	145587554	315	23547											
OFD1	8481	broad.mit.edu	37	chrX	13778324	13778324	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggcaatgtggtgccttgcaAtggtgagataagtggggatt	9	12	16	4	0	0	1	0	1	0	1	0	3	0	2	1	5	2	2	1	5	3	3			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chrX:13778324A>T	uc004cvp.3	+	16	2104	c.1745A>T	c.(1744-1746)AAT>ATT	p.N582I	OFD1_uc004cvr.3_Missense_Mutation_p.N149I|OFD1_uc011mil.1_Missense_Mutation_p.N149I|OFD1_uc004cvq.3_Missense_Mutation_p.N442I|OFD1_uc010nen.2_Missense_Mutation_p.N581I|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.N541I|OFD1_uc004cvv.3_Missense_Mutation_p.N541I	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	582					cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						GTGCCTTGCAATGGTGAGATA	0.423													19	108					0	0	0	0	T	13778324	T	T	13778324	3	4	130	1	0	0	0	0	1	0	0	0	10892	101	4	5	1807	5	OFD1	23	13778324	Missense_Mutation	SNP	A	TCGA-CR-6484-01A-11D-1870-08	4095318	13778324	141492236	316	23548											
ACE2	59272	broad.mit.edu	37	chrX	15584408	15584408	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaacttcagttctaggaatGatatcagacacatttttagg	13	14	7	7	0	4	2	3	1	1	1	4	3	4	3	0	2	1	1	0	2	5	7			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chrX:15584408G>C	uc004cxa.1	-	16	2250	c.2082C>G	c.(2080-2082)ATC>ATG	p.I694M	ACE2_uc004cxb.2_Missense_Mutation_p.I694M	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	694	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	TTCTAGGAATGATATCAGACA	0.353													34	171					0	0	0	0	C	15584408	C	C	15584408	3	2	130	1	0	0	0	0	1	0	0	0	137	1280	45	2	347	2	ACE2	23	15584408	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	1806084	15584408	139686152	317	23549											
HUWE1	10075	broad.mit.edu	37	chrX	53589797	53589797	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcggcactctcaccttctCggttggcctgcaaggtggaa	6	10	11	14	2	2	0	1	0	2	0	5	1	2	1	3	5	1	3	3	5	2	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chrX:53589797C>T	uc004dsp.2	-	53	7601	c.7199G>A	c.(7198-7200)CGA>CAA	p.R2400Q	HUWE1_uc004dsn.2_Missense_Mutation_p.R1224Q	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2400	Glu-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CTCACCTTCTCGGTTGGCCTG	0.562													17	84					0	0	0	0	T	53589797	T	T	53589797	3	4	130	1	0	0	0	0	1	0	0	0	7500	884	31	1	6053	1	HUWE1	23	53589797	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	38005389	53589797	101680763	318	23550											
WNK3	65267	broad.mit.edu	37	chrX	54321097	54321097	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtttgctgagcgggagcaaGgggtaaagttgtattctggg	9	11	17	4	1	1	1	0	1	1	0	1	2	1	2	0	4	3	6	0	4	4	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chrX:54321097G>C	uc004dtd.1	-	8	2021	c.1582C>G	c.(1582-1584)CTT>GTT	p.L528V	WNK3_uc004dtc.1_Missense_Mutation_p.L528V	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	528					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GCGGGAGCAAGGGGTAAAGTT	0.478													9	38					0	0	0	0	C	54321097	C	C	54321097	3	2	130	1	0	0	0	0	1	0	0	0	17447	1000	35	4	3888	4	WNK3	23	54321097	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	731300	54321097	100949463	319	23551											
ATP7A	538	broad.mit.edu	37	chrX	77301958	77301958	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttatagcagagcctctataaActcactactgtctgataaac	14	12	5	10	0	3	2	1	1	2	1	3	2	3	2	1	0	5	1	1	0	8	6			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chrX:77301958A>G	uc004ecx.3	+	23	4554	c.4394A>G	c.(4393-4395)AAC>AGC	p.N1465S		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1465	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						GCCTCTATAAACTCACTACTG	0.438													60	239					0	0	0	0	G	77301958	G	G	77301958	3	3	130	1	0	0	0	0	1	0	0	0	1192	43	2	5	4480	5	ATP7A	23	77301958	Missense_Mutation	SNP	A	TCGA-CR-6484-01A-11D-1870-08	22980861	77301958	77968602	320	23552											
CPXCR1	53336	broad.mit.edu	37	chrX	88008988	88008988	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatagtttcacccatcacgaGagagccataacatttagaag	16	9	7	9	1	2	2	2	0	0	2	2	4	2	2	2	0	2	1	2	0	5	5			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chrX:88008988G>C	uc004efd.3	+	3	832	c.573G>C	c.(571-573)GAG>GAC	p.E191D	CPXCR1_uc004efc.3_Missense_Mutation_p.E191D	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	191						intracellular	zinc ion binding			ovary(3)	3						CCCATCACGAGAGAGCCATAA	0.423													5	37					0	0	0	0	C	88008988	C	C	88008988	3	2	130	1	0	0	0	0	1	0	0	0	3851	933	33	2	575	2	CPXCR1	23	88008988	Missense_Mutation	SNP	G	TCGA-CR-6484-01A-11D-1870-08	10707030	88008988	67261572	321	23553											
PCDH11X	27328	broad.mit.edu	37	chrX	91134270	91134270	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtgtccgtacacaccagaCcggtaggtatccaagtttct	9	11	9	12	2	1	1	0	0	1	1	3	1	3	1	4	2	1	4	4	2	4	4			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chrX:91134270C>G	uc004efk.1	+	2	3876	c.3031C>G	c.(3031-3033)CCG>GCG	p.P1011A	PCDH11X_uc004efl.1_Missense_Mutation_p.P1011A|PCDH11X_uc004efo.1_Missense_Mutation_p.P1011A|PCDH11X_uc010nmv.1_Missense_Mutation_p.P1011A|PCDH11X_uc004efm.1_Missense_Mutation_p.P1011A|PCDH11X_uc004efn.1_Missense_Mutation_p.P1011A|PCDH11X_uc004efh.1_Missense_Mutation_p.P1011A|PCDH11X_uc004efj.1_Missense_Mutation_p.P1011A	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1011	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ACACACCAGACCGGTAGGTAT	0.403													18	94					0	0	0	0	G	91134270	G	G	91134270	3	3	130	1	0	0	0	0	1	0	0	0	11562	507	18	4	3037	4	PCDH11X	23	91134270	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	3125282	91134270	64136290	322	23554											
ARMCX2	9823	broad.mit.edu	37	chrX	100911437	100911437	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggacacccagaatctcatCaatttcataaggaaaggggc	14	7	10	10	1	3	1	3	0	1	1	4	3	3	3	1	4	0	0	1	4	4	2			TCGA-CR-6484-01A-11D-1870-08	TCGA-CR-6484-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e72df726-1575-4789-afac-3b15a7643401	b0fa7dd3-58da-45b8-bff4-1d665e21df9f	g.chrX:100911437C>G	uc004eid.2	-	3	1493	c.1138G>C	c.(1138-1140)GAT>CAT	p.D380H	ARMCX2_uc004eie.3_Missense_Mutation_p.D380H|ARMCX2_uc004eif.3_Missense_Mutation_p.D380H|ARMCX2_uc004eig.3_Missense_Mutation_p.D380H|ARMCX2_uc010nnt.2_Missense_Mutation_p.D380H	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	380	ARM 1.					integral to membrane	binding			ovary(6)	6						AGAATCTCATCAATTTCATAA	0.517													17	79					0	0	0	0	G	100911437	G	G	100911437	3	3	130	1	0	0	0	0	1	0	0	0	962	826	29	2	764	2	ARMCX2	23	100911437	Missense_Mutation	SNP	C	TCGA-CR-6484-01A-11D-1870-08	9777167	100911437	54359123	323	23555											
NPHP4	261734	broad.mit.edu	37	chr1	5935081	5935081	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctcagcaggctggcgatgCtctcggccttcgtgcgttcc	3	10	14	14	4	2	0	1	0	1	0	5	1	3	0	2	4	3	5	2	4	0	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:5935081C>A	uc001alq.1	-	21	3163	c.2897G>T	c.(2896-2898)AGC>ATC	p.S966I		NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	966					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGGCGATGCTCTCGGCCTT	0.642													4	27					1.23904e-05	1.26704e-05	1	0	A	5935081	A	A	5935081	3	1	131	1	0	0	0	0	1	0	0	0	10635	797	28	4	1423	4	NPHP4	1	5935081	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08		5935081	243315540	1	23556											
EXOSC10	5394	broad.mit.edu	37	chr1	11151235	11151235	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttttgccatattctgctGcctatgatcaatgaatacaa	11	16	5	9	0	2	2	1	2	1	0	2	2	2	2	2	0	4	1	2	0	6	7			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:11151235G>A	uc001asa.2	-	5	529	c.479C>T	c.(478-480)GCA>GTA	p.A160V	EXOSC10_uc001asb.2_Missense_Mutation_p.A160V|EXOSC10_uc009vmy.1_Missense_Mutation_p.A160V	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	160					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		ATATTCTGCTGCCTATGATCA	0.353													14	67					0	0	0	0	A	11151235	A	A	11151235	3	1	131	1	0	0	0	0	1	0	0	0	5338	1333	46	4	2262	4	EXOSC10	1	11151235	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	5216154	11151235	238099386	2	23557											
MFN2	9927	broad.mit.edu	37	chr1	12056346	12056346	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaggcctttctccttaccGagggctcagaggaaaagagg	11	8	13	9	1	2	3	1	1	1	2	3	5	2	4	3	4	1	1	3	4	3	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:12056346G>A	uc001atn.3	+	5	898	c.445G>A	c.(445-447)GAG>AAG	p.E149K	MFN2_uc009vni.2_Missense_Mutation_p.E149K	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	149	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TCTCCTTACCGAGGGCTCAGA	0.602													6	44					0	0	0	0	A	12056346	A	A	12056346	3	1	131	1	0	0	0	0	1	0	0	0	9577	1059	37	1	455	1	MFN2	1	12056346	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	905111	12056346	237194275	3	23558											
GJB5	2709	broad.mit.edu	37	chr1	35223201	35223201	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgacatgcccctcactgctCgtggtcatgcacgtggccta	6	10	11	14	2	2	1	2	1	0	0	3	1	2	1	3	2	3	2	3	2	1	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:35223201C>T	uc001bxu.2	+	2	370	c.270C>T	c.(268-270)CTC>CTT	p.L90L	GJB4_uc001bxv.1_5'Flank	NM_005268	NP_005259	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	90	Helical; (Potential).				cell communication|epidermis development	connexon complex|integral to membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)				CCTCACTGCTCGTGGTCATGC	0.617													17	69					0	0	0	0	T	35223201	T	T	35223201	2	4	131	1	0	0	0	0	0	0	0	1	6448	871	31	1		1	GJB5	1	35223201	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	23166855	35223201	214027420	4	23559											
LMO4	8543	broad.mit.edu	37	chr1	87805751	87805751	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttacatgctctacctgcCggaatcgcctggtcccggga	6	11	11	13	3	1	0	0	0	1	0	3	2	2	2	4	3	4	2	4	3	3	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:87805751C>T	uc001dmi.2	+	4	1135	c.355C>T	c.(355-357)CGG>TGG	p.R119W	LMO4_uc001dmj.2_Missense_Mutation_p.R119W	NM_006769	NP_006760	P61968	LMO4_HUMAN	LIM domain only 4	119	LIM zinc-binding 2.				neural tube closure|transcription from RNA polymerase II promoter	transcription factor complex	sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding				0		Lung NSC(277;0.179)		all cancers(265;0.00456)|Epithelial(280;0.0148)|BRCA - Breast invasive adenocarcinoma(282;0.153)		CTCTACCTGCCGGAATCGCCT	0.393													25	113					0	0	0	0	T	87805751	T	T	87805751	3	4	131	1	0	0	0	0	1	0	0	0	8896	643	23	1	365	1	LMO4	1	87805751	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	52582550	87805751	161444870	5	23560											
PKN2	5586	broad.mit.edu	37	chr1	89279371	89279371	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atatgctgccggtggggaccTaatgatgcacattcatactg	10	11	11	9	1	1	1	1	1	0	0	1	2	1	2	2	3	4	2	2	3	3	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:89279371T>C	uc001dmn.2	+	16	2576	c.2234T>C	c.(2233-2235)CTA>CCA	p.L745P	PKN2_uc010osp.1_Missense_Mutation_p.L729P|PKN2_uc010osq.1_Missense_Mutation_p.L588P|PKN2_uc009wcv.2_Missense_Mutation_p.L697P|PKN2_uc010osr.1_Missense_Mutation_p.L410P	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	745	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		GGTGGGGACCTAATGATGCAC	0.408													3	176					0	0	0	0	C	89279371	C	C	89279371	3	2	131	1	0	0	0	0	1	0	0	0	12035	1522	53	5	2296	5	PKN2	1	89279371	Missense_Mutation	SNP	T	TCGA-CR-6487-01A-11D-1870-08	1473620	89279371	159971250	6	23561											
ABCA4	24	broad.mit.edu	37	chr1	94505666	94505666	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtggagaaacccttagaCgagcagctgcaggtcccctg	9	7	14	11	1	0	2	0	0	0	2	1	4	1	2	3	3	4	3	3	3	2	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:94505666C>T	uc001dqh.2	-	24	3644	c.3540G>A	c.(3538-3540)TCG>TCA	p.S1180S		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1180	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AACCCTTAGACGAGCAGCTGC	0.572											OREG0013610	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	12					0	0	0	0	T	94505666	T	T	94505666	2	4	131	1	0	0	0	0	0	0	0	1	34	523	19	1		1	ABCA4	1	94505666	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	5226295	94505666	154744955	7	23562											
LPPR4	9890	broad.mit.edu	37	chr1	99771596	99771596	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cattcatgcctctatggattCcgctcgatcaaagcagctcc	9	11	7	14	2	3	0	2	0	1	0	6	2	5	1	3	1	3	3	3	1	2	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:99771596C>T	uc001dse.2	+	7	1428	c.1322C>T	c.(1321-1323)TCC>TTC	p.S441F	LPPR4_uc010oue.1_Missense_Mutation_p.S383F	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	441							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TCTATGGATTCCGCTCGATCA	0.498													18	75					0	0	0	0	T	99771596	T	T	99771596	3	4	131	1	0	0	0	0	1	0	0	0	8977	855	30	2	1348	2	LPPR4	1	99771596	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	5265930	99771596	149479025	8	23563											
ADORA3	140	broad.mit.edu	37	chr1	112031442	112031442	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttggtcaggcaggacataGtgacaatgagctggttccct	9	11	12	9	0	1	2	1	2	0	0	2	3	2	3	1	4	1	3	1	4	2	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:112031442G>A	uc001ebf.2	-	3	1429	c.662C>T	c.(661-663)ACT>ATT	p.T221I	ADORA3_uc001ebg.3_Missense_Mutation_p.T140I	NM_020683	NP_065734	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 1	Error:Variant_position_missing_in_P33765_after_alignment					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GCAGGACATAGTGACAATGAG	0.532													12	36					0	0	0	0	A	112031442	A	A	112031442	3	1	131	1	0	0	0	0	1	0	0	0	329	1029	36	4	397	4	ADORA3	1	112031442	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	12259846	112031442	137219179	9	23564											
MAN1A2	10905	broad.mit.edu	37	chr1	117984891	117984891	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtgcaattggctgagaaactCcttcctgcctttaacacacc	10	11	7	13	0	0	1	0	1	0	1	2	2	2	1	4	1	4	2	4	1	3	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:117984891C>G	uc001ehd.1	+	6	1615	c.894C>G	c.(892-894)CTC>CTG	p.L298L	MAN1A2_uc009whg.1_Silent_p.L88L	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	298	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		CTGAGAAACTCCTTCCTGCCT	0.343													14	97					0	0	0	0	G	117984891	G	G	117984891	2	3	131	1	0	0	0	0	0	0	0	1	9264	842	30	2		2	MAN1A2	1	117984891	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	5953449	117984891	131265730	10	23565											
NBPF10	100132406	broad.mit.edu	37	chr1	145323663	145323663	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgtattgcaggaattaaaaAggacgaagaagaggaagaag	20	6	13	2	1	0	3	0	0	0	3	0	7	0	6	0	3	1	2	0	3	9	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:145323663A>G	uc001end.3	+	29	3760	c.3725A>G	c.(3724-3726)AAG>AGG	p.K1242R	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oym.1_Intron|NBPF10_uc010oyn.1_Intron|NBPF10_uc010oyo.1_Intron|NBPF10_uc010oyp.1_5'Flank	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	1167											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GGAATTAAAAAGGACGAAGAA	0.463													6	773					0	0	0	0	G	145323663	G	G	145323663	3	3	131	1	0	0	0	0	1	0	0	0	10246	72	3	5	3606	5	NBPF10	1	145323663	Missense_Mutation	SNP	A	TCGA-CR-6487-01A-11D-1870-08	27338772	145323663	103926958	11	23566											
FLG2	388698	broad.mit.edu	37	chr1	152331346	152331346	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attacggtgacaacacttctCaagaggtcggtcatcttttt	10	14	8	9	2	3	2	2	1	2	1	5	2	3	2	0	3	2	0	0	3	3	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:152331346C>G	uc001ezw.3	-	2	88	c.15G>C	c.(13-15)TTG>TTC	p.L5F	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	5	S-100-like (By similarity).						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAACACTTCTCAAGAGGTCGG	0.393													13	62					0	0	0	0	G	152331346	G	G	152331346	3	3	131	1	0	0	0	0	1	0	0	0	5955	825	29	2	7168	2	FLG2	1	152331346	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	7007683	152331346	96919275	12	23567											
NUP210L	91181	broad.mit.edu	37	chr1	154029395	154029395	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctcgaagaatataattttCagagtattcgtcctgttgct	11	15	8	7	2	1	2	1	0	0	2	4	3	2	2	1	0	2	4	1	0	5	7			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:154029395C>G	uc001fdw.2	-	23	3208	c.3136G>C	c.(3136-3138)GAA>CAA	p.E1046Q	NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Missense_Mutation_p.E1046Q	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1046						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ATATAATTTTCAGAGTATTCG	0.343													11	48					0	0	0	0	G	154029395	G	G	154029395	3	3	131	1	0	0	0	0	1	0	0	0	10815	835	29	2	2602	2	NUP210L	1	154029395	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	1698049	154029395	95221226	13	23568											
UBE2Q1	55585	broad.mit.edu	37	chr1	154525286	154525286	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtggcctgcaccgagccaGacactgcaccctgtgaggga	9	5	13	14	1	0	2	0	1	0	1	0	4	0	3	4	2	3	2	4	2	0	0			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:154525286G>C	uc001fff.1	-	6	831	c.740C>G	c.(739-741)TCT>TGT	p.S247C		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	247							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CACCGAGCCAGACACTGCACC	0.562													9	50					0	0	0	0	C	154525286	C	C	154525286	3	2	131	1	0	0	0	0	1	0	0	0	16937	942	33	2	560	2	UBE2Q1	1	154525286	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	495891	154525286	94725335	14	23569											
RXRG	6258	broad.mit.edu	37	chr1	165398095	165398095	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccactgcactcagagtccgtGgggcactcactggggtatct	7	9	12	13	1	3	1	2	0	1	1	4	1	4	1	2	4	1	3	2	4	1	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:165398095G>C	uc001gda.2	-	2	458	c.158C>G	c.(157-159)CCA>CGA	p.P53R		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	53	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CAGAGTCCGTGGGGCACTCAC	0.617													9	31					0	0	0	0	C	165398095	C	C	165398095	3	2	131	1	0	0	0	0	1	0	0	0	13830	1348	47	4	1269	4	RXRG	1	165398095	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	10872809	165398095	83852526	15	23570											
LHX4	89884	broad.mit.edu	37	chr1	180240979	180240979	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtgtggcaggtttggtttCagaacagaagggccaaagag	11	10	15	5	0	1	3	1	0	0	3	1	3	1	3	1	4	1	3	1	4	3	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:180240979C>T	uc001goe.1	+	5	839	c.616C>T	c.(616-618)CAG>TAG	p.Q206*	uc001gof.1_RNA	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	206	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GGTTTGGTTTCAGAACAGAAG	0.607													25	113					0	0	0	0	T	180240979	T	T	180240979	4	4	131	1	0	0	0	0	0	1	0	0	8814	827	29	2	634	2	LHX4	1	180240979	Nonsense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	14842884	180240979	69009642	16	23571											
KLHDC8A	55220	broad.mit.edu	37	chr1	205306592	205306592	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggttgacacctcccacggCgaggaggcagttcttgacga	8	8	13	12	3	1	2	0	2	1	0	2	5	2	3	2	4	0	3	2	4	0	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:205306592C>T	uc001hcf.1	-	6	1556	c.988G>A	c.(988-990)GCC>ACC	p.A330T	KLHDC8A_uc010prg.1_Missense_Mutation_p.A217T|KLHDC8A_uc001hcg.1_Missense_Mutation_p.A330T	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	330										ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CCTCCCACGGCGAGGAGGCAG	0.597													32	118					0	0	0	0	T	205306592	T	T	205306592	3	4	131	1	0	0	0	0	1	0	0	0	8401	768	27	1	68	1	KLHDC8A	1	205306592	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	25065613	205306592	43944029	17	23572											
OBSCN	84033	broad.mit.edu	37	chr1	228476582	228476582	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacctctgccactctcacCgtgaagggtaatgactgctc	9	9	10	13	1	2	2	1	2	2	0	4	3	2	3	3	2	2	2	3	2	2	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr1:228476582C>T	uc009xez.1	+	38	10376	c.10332C>T	c.(10330-10332)ACC>ACT	p.T3444T	OBSCN_uc001hsn.2_Silent_p.T3444T|OBSCN_uc001hsq.1_Silent_p.T700T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3444	Ig-like 34.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCACTCTCACCGTGAAGGGTA	0.612													9	43					0	0	0	0	T	228476582	T	T	228476582	2	4	131	1	0	0	0	0	0	0	0	1	10866	639	23	1		1	OBSCN	1	228476582	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	23169990	228476582	20774039	18	23573											
NBAS	51594	broad.mit.edu	37	chr2	15415898	15415898	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaactggctccaatgcttCaagaggactcatgttttcat	12	12	8	9	0	3	2	3	0	0	2	4	3	4	3	1	2	2	3	1	2	4	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:15415898C>G	uc002rcc.1	-	44	5460	c.5434G>C	c.(5434-5436)GAA>CAA	p.E1812Q	NBAS_uc010exl.1_Missense_Mutation_p.E884Q|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1812										ovary(2)|liver(1)|skin(1)	4						TCCAATGCTTCAAGAGGACTC	0.373													11	76					0	0	0	0	G	15415898	G	G	15415898	3	3	131	1	0	0	0	0	1	0	0	0	10239	835	29	2	1717	2	NBAS	2	15415898	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08		15415898	227783475	19	23574											
LRP1B	53353	broad.mit.edu	37	chr2	140992403	140992403	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtttaggtagatgggcggCgctgtgtgtggaagcttgaa	8	11	18	4	2	0	2	0	1	0	1	0	4	0	3	0	4	1	4	0	4	4	4	rs149169898	byFrequency	TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:140992403C>T	uc002tvj.1	-	90	14583	c.13611G>A	c.(13609-13611)GCG>GCA	p.A4537A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4537	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		agatgggcggcgctgtgtgtg	0.06										TSP Lung(27;0.18)			7	46					0	0	0	0	T	140992403	T	T	140992403	2	4	131	1	0	0	0	0	0	0	0	1	9005	755	27	1		1	LRP1B	2	140992403	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	125576505	140992403	102206970	20	23575											
MYO3B	140469	broad.mit.edu	37	chr2	171055792	171055792	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acttccagatcccacagacaCctgggaaattatagagacca	15	7	7	12	0	0	3	0	0	0	3	2	5	2	4	4	1	0	0	4	1	3	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:171055792C>T	uc002ufy.2	+	2	220	c.77C>T	c.(76-78)ACC>ATC	p.T26I	MYO3B_uc002ufv.2_Missense_Mutation_p.T13I|MYO3B_uc010fqb.1_Missense_Mutation_p.T13I|MYO3B_uc002ufz.2_Missense_Mutation_p.T26I|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002uga.2_Missense_Mutation_p.T13I	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	26					response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						CCCACAGACACCTGGGAAATT	0.413													8	43					0	0	0	0	T	171055792	T	T	171055792	3	4	131	1	0	0	0	0	1	0	0	0	10130	507	18	4	83	4	MYO3B	2	171055792	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	30063389	171055792	72143581	21	23576											
TTN	7273	broad.mit.edu	37	chr2	179604387	179604387	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagatcagatatttagattCaacttctggttcagtaatgg	12	15	9	5	0	4	3	3	1	1	3	4	4	4	3	0	2	1	2	0	2	4	7			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:179604387C>T	uc010zfh.1	-	46	13284	c.13060G>A	c.(13060-13062)GAA>AAA	p.E4354K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E4287K|TTN_uc010zfj.1_Missense_Mutation_p.E4162K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	4280							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTTAGATTCAACTTCTGGT	0.398													29	99					0	0	0	0	T	179604387	T	T	179604387	3	4	131	1	0	0	0	0	1	0	0	0	16803	835	29	2	91216	2	TTN	2	179604387	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	8548595	179604387	63594986	22	23577											
MAP2	4133	broad.mit.edu	37	chr2	210559886	210559886	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gattaggagtaacctatgagCaagctttggccaaagatttg	13	11	11	6	0	0	2	0	1	0	1	0	4	0	3	2	2	3	3	2	2	5	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:210559886C>A	uc002vde.1	+	7	3240	c.2992C>A	c.(2992-2994)CAA>AAA	p.Q998K	MAP2_uc002vdc.1_Missense_Mutation_p.Q998K|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.Q994K	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	998					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AACCTATGAGCAAGCTTTGGC	0.418													8	60					0.000157383	0.000159142	1	0	A	210559886	A	A	210559886	3	1	131	1	0	0	0	0	1	0	0	0	9288	711	25	4	3006	4	MAP2	2	210559886	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	30955499	210559886	32639487	23	23578											
CPS1	1373	broad.mit.edu	37	chr2	211459299	211459299	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caccattacatcagtcttacCgaagccagcactagttgcat	12	10	6	13	1	2	0	1	0	1	0	2	1	2	0	3	0	5	3	3	0	4	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:211459299C>T	uc002vee.3	+	12	1364	c.1232C>T	c.(1231-1233)CCG>CTG	p.P411L	CPS1_uc010fur.2_Missense_Mutation_p.P417L|CPS1_uc010fus.2_5'UTR	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	411					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TCAGTCTTACCGAAGCCAGCA	0.363													10	41					0	0	0	0	T	211459299	T	T	211459299	3	4	131	1	0	0	0	0	1	0	0	0	3838	652	23	1	1300	1	CPS1	2	211459299	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	899413	211459299	31740074	24	23579											
STK36	27148	broad.mit.edu	37	chr2	219559301	219559301	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcaaggggtgacctttgaCctccagcccatggaatggat	10	8	12	11	0	0	2	0	2	0	0	1	4	1	4	4	4	2	1	4	4	2	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:219559301C>T	uc002viu.2	+	21	2720	c.2454C>T	c.(2452-2454)GAC>GAT	p.D818D	STK36_uc002viv.2_Silent_p.D818D|STK36_uc002viw.2_5'UTR|STK36_uc002vix.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	818					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		TGACCTTTGACCTCCAGCCCA	0.552													20	84					0	0	0	0	T	219559301	T	T	219559301	2	4	131	1	0	0	0	0	0	0	0	1	15368	506	18	4		4	STK36	2	219559301	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	8100002	219559301	23640072	25	23580											
MSL3L2	151507	broad.mit.edu	37	chr2	234775835	234775835	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctagagttactgttctttCttccatttccctttttgttt	4	24	4	9	0	3	1	0	0	3	1	5	1	5	1	2	0	1	3	2	0	2	10			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:234775835C>G	uc010znf.1	-	2	245	c.7G>C	c.(7-9)GAA>CAA	p.E3Q		NR_024322				SubName: Full=cDNA FLJ52683, highly similar to Male-specific lethal 3-like 1; SubName: Full=cDNA, FLJ79271, highly similar to Male-specific lethal 3-like 1; SubName: Full=HCG1642047;												0						ACTGTTCTTTCTTCCATTTCC	0.383													4	32					0	0	0	0	G	234775835	G	G	234775835	3	3	131	1	0	0	0	0	1	0	0	0	9933	922	32	2	1067	2	MSL3L2	2	234775835	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	15216534	234775835	8423538	26	23581											
COL6A3	1293	broad.mit.edu	37	chr2	238277502	238277502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggcaccccgtcttctatgCgactccccgcagacttaaca	8	8	9	16	3	2	1	0	0	2	1	3	2	3	1	4	2	2	2	4	2	2	3	rs115765346	by1000genomes	TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr2:238277502C>T	uc002vwl.2	-	10	4889	c.4604G>A	c.(4603-4605)CGC>CAC	p.R1535H	COL6A3_uc002vwo.2_Missense_Mutation_p.R1329H|COL6A3_uc010znj.1_Missense_Mutation_p.R928H	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1535	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GTCTTCTATGCGACTCCCCGC	0.592													11	65					0	0	0	0	T	238277502	T	T	238277502	3	4	131	1	0	0	0	0	1	0	0	0	3716	768	27	1	5069	1	COL6A3	2	238277502	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	3501667	238277502	4921871	27	23582											
NISCH	11188	broad.mit.edu	37	chr3	52521429	52521429	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacagggcgaggaggaggatGaggaggaggaagaagaggag	16	1	22	2	1	0	3	0	1	0	2	0	11	0	10	0	8	1	0	0	8	3	0			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:52521429G>A	uc011beg.1	+	17	1993	c.1921G>A	c.(1921-1923)GAG>AAG	p.E641K	NISCH_uc003ded.3_Missense_Mutation_p.E641K|NISCH_uc003dee.3_Missense_Mutation_p.E130K|NISCH_uc003deg.1_RNA	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	641	Necessary for homooligomerization and targeting to endosomes.|Potential.|Glu-rich.|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		ggaggaggatgaggaggagga	0.428													12	23					0	0	0	0	A	52521429	A	A	52521429	3	1	131	1	0	0	0	0	1	0	0	0	10486	1291	45	2	1983	2	NISCH	3	52521429	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08		52521429	145501001	28	23583											
ZBTB11	27107	broad.mit.edu	37	chr3	101370392	101370392	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatatgtttacggagtgttCgagcatctatgtaggcttcg	8	15	11	7	3	2	0	1	0	1	0	4	2	2	1	0	2	2	5	0	2	4	7			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:101370392C>A	uc003dve.3	-	11	3010	c.2780G>T	c.(2779-2781)CGA>CTA	p.R927L		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	927	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ACGGAGTGTTCGAGCATCTAT	0.448													28	114					2.48779e-11	2.61797e-11	1	0	A	101370392	A	A	101370392	3	1	131	1	0	0	0	0	1	0	0	0	17591	884	31	3	385	3	ZBTB11	3	101370392	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	48848963	101370392	96652038	29	23584											
C3orf30	152405	broad.mit.edu	37	chr3	118865322	118865322	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagagcatccaaccctgctGatgtttctgaccttagagca	10	10	9	12	0	1	4	0	2	1	2	2	4	2	4	3	0	4	5	3	0	2	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:118865322G>A	uc003ecb.1	+	1	326	c.286G>A	c.(286-288)GAT>AAT	p.D96N	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Missense_Mutation_p.D96N	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	96										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		CAACCCTGCTGATGTTTCTGA	0.473													5	31					0	0	0	0	A	118865322	A	A	118865322	3	1	131	1	0	0	0	0	1	0	0	0	2230	1290	45	2	288	2	C3orf30	3	118865322	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	17494930	118865322	79157108	30	23585											
SLC15A2	6565	broad.mit.edu	37	chr3	121649690	121649690	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatctctaccctcaggttTgttaacactttgcataaaga	13	14	5	9	0	2	1	1	0	1	1	3	1	2	1	1	1	3	3	1	1	6	6			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:121649690T>C	uc003eep.2	+	18	1710	c.1557T>C	c.(1555-1557)TTT>TTC	p.F519F	SLC15A2_uc011bjn.1_Silent_p.F488F	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	519					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CCCTCAGGTTTGTTAACACTT	0.289													10	45					0	0	0	0	C	121649690	C	C	121649690	2	2	131	1	0	0	0	0	0	0	0	1	14464	1809	63	5		5	SLC15A2	3	121649690	Silent	SNP	T	TCGA-CR-6487-01A-11D-1870-08	2784368	121649690	76372740	31	23586											
PIK3CB	5291	broad.mit.edu	37	chr3	138417818	138417818	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagtgattgtgggaaaatCtctcggcagtcttgtcgcaa	9	11	13	8	2	2	1	0	1	2	0	5	2	2	2	0	3	0	3	0	3	3	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:138417818C>G	uc011bmq.1	-	11	1701	c.1701G>C	c.(1699-1701)GAG>GAC	p.E567D	PIK3CB_uc011bmn.1_Missense_Mutation_p.E79D|PIK3CB_uc011bmo.1_Missense_Mutation_p.E13D|PIK3CB_uc011bmp.1_Missense_Mutation_p.E154D	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	567	PI3K helical.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GTGGGAAAATCTCTCGGCAGT	0.378													21	104					0	0	0	0	G	138417818	G	G	138417818	3	3	131	1	0	0	0	0	1	0	0	0	11969	912	32	2	1557	2	PIK3CB	3	138417818	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	16768128	138417818	59604612	32	23587											
XRN1	54464	broad.mit.edu	37	chr3	142137436	142137436	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataggtcatcatcttcagtcTcatcttctaaattatctggg	10	16	6	9	0	8	0	4	0	5	0	9	0	8	0	0	2	0	0	0	2	4	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:142137436T>C	uc003eus.2	-	12	1323	c.1256A>G	c.(1255-1257)GAG>GGG	p.E419G	XRN1_uc003eut.2_Missense_Mutation_p.E419G|XRN1_uc003euu.2_Missense_Mutation_p.E419G|XRN1_uc003euv.1_Missense_Mutation_p.E280G|XRN1_uc003euw.2_Missense_Mutation_p.E419G|XRN1_uc011bnh.1_Missense_Mutation_p.E209G	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	419					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						ATCTTCAGTCTCATCTTCTAA	0.333													7	32					0	0	0	0	C	142137436	C	C	142137436	3	2	131	1	0	0	0	0	1	0	0	0	17527	1551	54	5	3988	5	XRN1	3	142137436	Missense_Mutation	SNP	T	TCGA-CR-6487-01A-11D-1870-08	3719618	142137436	55884994	33	23588											
SI	6476	broad.mit.edu	37	chr3	164750459	164750459	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctgatatgatgaatgtgTgcacacaatatctaatgtgt	12	15	8	6	0	1	3	0	3	1	0	2	3	2	3	1	0	1	1	1	0	5	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:164750459T>C	uc003fei.2	-	24	2649	c.2587A>G	c.(2587-2589)ACA>GCA	p.T863A		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	863	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GATGAATGTGTGCACACAATA	0.333										HNSCC(35;0.089)			6	64					0	0	0	0	C	164750459	C	C	164750459	3	2	131	1	0	0	0	0	1	0	0	0	14362	1696	59	5	2996	5	SI	3	164750459	Missense_Mutation	SNP	T	TCGA-CR-6487-01A-11D-1870-08	22613023	164750459	33271971	34	23589											
SERPINI1	5274	broad.mit.edu	37	chr3	167543055	167543055	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacaattctattcatgggaCgagtcatgcatcctgaaaca	13	11	8	9	1	3	1	2	1	1	0	4	3	4	2	1	1	3	2	1	1	4	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:167543055C>T	uc003ffa.3	+	9	1375	c.1177C>T	c.(1177-1179)CGA>TGA	p.R393*	SERPINI1_uc003ffb.3_Nonsense_Mutation_p.R393*	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	393					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						ATTCATGGGACGAGTCATGCA	0.318													44	516					0	0	0	0	T	167543055	T	T	167543055	4	4	131	1	0	0	0	0	0	1	0	0	14183	528	19	1	1207	1	SERPINI1	3	167543055	Nonsense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	2792596	167543055	30479375	35	23590											
TNIK	23043	broad.mit.edu	37	chr3	170800121	170800121	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgatcagattatagacttTgccttgcccacttcggtcca	8	14	8	11	1	1	3	1	1	0	2	3	3	2	3	3	1	2	1	3	1	2	6			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:170800121T>C	uc003fhh.2	-	27	3577	c.3232A>G	c.(3232-3234)AAA>GAA	p.K1078E	TNIK_uc003fhi.2_Missense_Mutation_p.K1023E|TNIK_uc003fhj.2_Missense_Mutation_p.K1049E|TNIK_uc003fhk.2_Missense_Mutation_p.K1070E|TNIK_uc003fhl.2_Missense_Mutation_p.K994E|TNIK_uc003fhm.2_Missense_Mutation_p.K1015E|TNIK_uc003fhn.2_Missense_Mutation_p.K1041E|TNIK_uc003fho.2_Missense_Mutation_p.K986E|TNIK_uc003fhg.2_Missense_Mutation_p.K256E|TNIK_uc003fhp.2_Missense_Mutation_p.K10E	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1078	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TTATAGACTTTGCCTTGCCCA	0.438													5	195					0	0	0	0	C	170800121	C	C	170800121	3	2	131	1	0	0	0	0	1	0	0	0	16379	1821	63	5	878	5	TNIK	3	170800121	Missense_Mutation	SNP	T	TCGA-CR-6487-01A-11D-1870-08	3257066	170800121	27222309	36	23591											
TBL1XR1	79718	broad.mit.edu	37	chr3	176769363	176769363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttgcagatccttgttggCtggctgcagctgcggcagct	4	14	13	10	1	0	1	0	0	0	1	1	1	1	1	1	3	5	8	1	3	0	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:176769363C>T	uc003fiw.3	-	5	616	c.356G>A	c.(355-357)AGC>AAC	p.S119N	TBL1XR1_uc003fix.3_Missense_Mutation_p.S119N|TBL1XR1_uc011bpz.1_5'UTR|TBL1XR1_uc003fiy.2_Missense_Mutation_p.S119N	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	119					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			TCCTTGTTGGCTGGCTGCAGC	0.453													13	290					0	0	0	0	T	176769363	T	T	176769363	3	4	131	1	0	0	0	0	1	0	0	0	15706	797	28	4	1236	4	TBL1XR1	3	176769363	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	5969242	176769363	21253067	37	23592											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			73	123					0	0	0	0	A	178936091	A	A	178936091	3	1	131	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	2166728	178936091	19086339	38	23593											
MFN1	55669	broad.mit.edu	37	chr3	179069808	179069808	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcggagacacatgaaggTggcattttttggcaggtaat	11	12	12	6	1	1	2	0	1	1	1	2	3	1	2	0	5	0	3	0	5	2	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:179069808T>C	uc003fjs.2	+	3	359	c.233T>C	c.(232-234)GTG>GCG	p.V78A	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.V106A	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	78	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CACATGAAGGTGGCATTTTTT	0.378													67	368					0	0	0	0	C	179069808	C	C	179069808	3	2	131	1	0	0	0	0	1	0	0	0	9576	1696	59	5	239	5	MFN1	3	179069808	Missense_Mutation	SNP	T	TCGA-CR-6487-01A-11D-1870-08	133717	179069808	18952622	39	23594											
MAP3K13	9175	broad.mit.edu	37	chr3	185190964	185190964	+	Frame_Shift_Del	DEL	A	-	-																															cagccagcccaggaaaattcAccccatcccacttacctgca																										TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:185190964delA	uc010hyf.2	+	12	2111	c.1845delA	c.(1843-1845)TCAfs	p.S615fs	MAP3K13_uc011brt.1_Frame_Shift_Del_p.S408fs|MAP3K13_uc011bru.1_Frame_Shift_Del_p.S471fs|MAP3K13_uc003fpi.2_Frame_Shift_Del_p.S615fs|MAP3K13_uc010hyg.2_Frame_Shift_Del_p.S305fs	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	615					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AGGAAAATTCACCCCATCCCA	0.532													---	---	---								-	185190964	-	-	185190964	7	5	131	1	0	1	0	1	0	0	0	0	9300	146	6	0	1883	0	MAP3K13	3	185190964	Frame_Shift_Del	DEL	A	TCGA-CR-6487-01A-11D-1870-08	6121156	185190964	12831466	40	23595											
ATP13A4	84239	broad.mit.edu	37	chr3	193166024	193166024	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacagtccttatccgggctGagatgagctcttccaagaca	10	11	9	11	1	1	3	0	2	1	2	4	4	4	3	3	1	2	2	3	1	3	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:193166024G>C	uc003ftd.2	-	18	2231	c.2123C>G	c.(2122-2124)TCA>TGA	p.S708*	ATP13A4_uc003fte.1_Nonsense_Mutation_p.S708*|ATP13A4_uc011bsr.1_Nonsense_Mutation_p.S179*|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	708	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TATCCGGGCTGAGATGAGCTC	0.393													12	176					0	0	0	0	C	193166024	C	C	193166024	4	2	131	1	0	0	0	0	0	1	0	0	1128	1294	45	2	1519	2	ATP13A4	3	193166024	Nonsense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	7975060	193166024	4856406	41	23596											
BDH1	622	broad.mit.edu	37	chr3	197241274	197241274	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagatgccggcattgttaacGaggccccacatgcctggaca	10	7	12	12	2	0	1	0	0	0	1	0	4	0	2	4	3	3	2	4	3	1	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr3:197241274G>A	uc003fxr.2	-	7	825	c.423C>T	c.(421-423)CTC>CTT	p.L141L	BDH1_uc003fxs.2_Silent_p.L141L|BDH1_uc003fxt.2_Silent_p.L54L|BDH1_uc003fxu.2_Silent_p.L141L	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	141					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	CATTGTTAACGAGGCCCCACA	0.587													13	211					0	0	0	0	A	197241274	A	A	197241274	2	1	131	1	0	0	0	0	0	0	0	1	1392	1045	37	1		1	BDH1	3	197241274	Silent	SNP	G	TCGA-CR-6487-01A-11D-1870-08	4075250	197241274	781156	42	23597											
FAM193A	8603	broad.mit.edu	37	chr4	2661312	2661312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ataagaaagcagttactggcGagaacaacttcacagacacc	17	6	8	10	1	1	3	1	0	0	3	1	4	1	3	1	1	4	2	1	1	5	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr4:2661312G>A	uc010icl.2	+	7	895	c.544G>A	c.(544-546)GAG>AAG	p.E182K	FAM193A_uc010ick.2_Missense_Mutation_p.E382K|FAM193A_uc003gfd.2_Missense_Mutation_p.E182K|FAM193A_uc011bvm.1_Missense_Mutation_p.E206K|FAM193A_uc011bvn.1_Missense_Mutation_p.E182K|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.E36K	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	182										ovary(3)	3						AGTTACTGGCGAGAACAACTT	0.453													9	39					0	0	0	0	A	2661312	A	A	2661312	3	1	131	1	0	0	0	0	1	0	0	0	5552	1059	37	1	562	1	FAM193A	4	2661312	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08		2661312	188492964	43	23598											
KCTD8	386617	broad.mit.edu	37	chr4	44449818	44449818	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagacctccttggccagcgcGatgcgcccgcacaccatgat	9	6	10	16	4	0	2	0	1	0	1	1	3	1	2	5	1	2	1	5	1	1	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr4:44449818G>A	uc003gwu.2	-	1	1007	c.723C>T	c.(721-723)ATC>ATT	p.I241I		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	241						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TGGCCAGCGCGATGCGCCCGC	0.667										HNSCC(17;0.042)			4	12					0	0	0	0	A	44449818	A	A	44449818	2	1	131	1	0	0	0	0	0	0	0	1	8154	1048	37	1		1	KCTD8	4	44449818	Silent	SNP	G	TCGA-CR-6487-01A-11D-1870-08	41788506	44449818	146704458	44	23599											
SMAD1	4086	broad.mit.edu	37	chr4	146467854	146467854	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataacattttctttcctctaGatgttcaggcggttgcttat	8	18	7	8	1	3	1	1	0	2	1	4	1	4	1	1	2	2	3	1	2	3	8			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr4:146467854G>A	uc003ikc.2	+	5	1192	c.776_splice	c.e5-1	p.D259_splice	SMAD1_uc003ikd.2_Splice_Site_p.D259_splice|SMAD1_uc010iov.2_Splice_Site_p.D259_splice|SMAD1_uc011cic.1_Splice_Site_p.D220_splice	NM_005900	NP_005891	Q15797	SMAD1_HUMAN	Sma- and Mad-related protein 1						BMP signaling pathway|embryonic pattern specification|primary miRNA processing|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|nuclear inner membrane	co-SMAD binding|I-SMAD binding|identical protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			ovary(1)	1	all_hematologic(180;0.151)					CTTTCCTCTAGATGTTCAGGC	0.448													40	103					0	0	0	0	A	146467854	A	A	146467854	5	1	131	1	0	0	0	0	0	0	1	0	14821	956	33	2	789	2	SMAD1	4	146467854	Splice_Site	SNP	G	TCGA-CR-6487-01A-11D-1870-08	102018036	146467854	44686422	45	23600											
POC5	134359	broad.mit.edu	37	chr5	74981280	74981280	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaacaccaggaccatactCttcctttttattatttgtgg	9	17	6	9	0	1	1	0	1	1	0	2	2	2	2	3	2	2	0	3	2	4	8			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:74981280C>G	uc003keh.3	-	10	1356	c.1159G>C	c.(1159-1161)GAG>CAG	p.E387Q	POC5_uc010izu.2_Missense_Mutation_p.E270Q|POC5_uc003keg.3_Missense_Mutation_p.E362Q	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	387					cell cycle	centriole				lung(1)	1						GGACCATACTCTTCCTTTTTA	0.398													17	139					0	0	0	0	G	74981280	G	G	74981280	3	3	131	1	0	0	0	0	1	0	0	0	12232	922	32	2	580	2	POC5	5	74981280	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08		74981280	105933980	46	23601											
CTNNA1	1495	broad.mit.edu	37	chr5	138145823	138145823	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagctcgagctttgctctCtgctgttacccggttgctga	4	13	12	12	2	1	1	0	1	1	0	3	2	1	1	1	2	6	8	1	2	1	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:138145823C>G	uc003ldh.2	+	4	493	c.398C>G	c.(397-399)TCT>TGT	p.S133C	CTNNA1_uc011cyx.1_Missense_Mutation_p.S30C|CTNNA1_uc011cyy.1_Missense_Mutation_p.S10C|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_Missense_Mutation_p.S133C	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	133	Interaction with JUP and CTNNB1.|Involved in homodimerization.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GCTTTGCTCTCTGCTGTTACC	0.478													28	62					0	0	0	0	G	138145823	G	G	138145823	3	3	131	1	0	0	0	0	1	0	0	0	4029	913	32	2	408	2	CTNNA1	5	138145823	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	63164543	138145823	42769437	47	23602											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139918552	139918552	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccataataccctctcatcctCagcttgctgatgttccagga	9	12	6	14	0	2	1	2	1	1	0	5	2	4	2	4	1	3	3	4	1	2	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:139918552C>T	uc003lfs.1	+	33	7577	c.7453C>T	c.(7453-7455)CAG>TAG	p.Q2485*	ANKHD1_uc003lfr.2_Nonsense_Mutation_p.Q2485*|ANKHD1-EIF4EBP3_uc011czh.1_Nonsense_Mutation_p.Q1241*|ANKHD1_uc003lfw.2_Nonsense_Mutation_p.Q1140*|ANKHD1_uc010jfl.2_Nonsense_Mutation_p.Q861*|ANKHD1-EIF4EBP3_uc003lfx.1_Nonsense_Mutation_p.Q630*	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2485						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTCATCCTCAGCTTGCTGA	0.363													20	75					0	0	0	0	T	139918552	T	T	139918552	4	4	131	1	0	0	0	0	0	1	0	0	629	827	29	2	7583	2	ANKHD1-EIF4EBP3	5	139918552	Nonsense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	1772729	139918552	40996708	48	23603											
PCDHA1	56147	broad.mit.edu	37	chr5	140165875	140165875	+	5'Flank	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaggtgtagtccttttgcAatggtgttttctaggagagg	9	14	14	4	0	1	1	0	0	1	1	2	3	2	1	1	4	1	3	1	4	4	6			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:140165875A>G	uc003lhb.2	+						PCDHA1_uc003lha.2_5'Flank|PCDHA1_uc003lgz.2_5'Flank	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor						homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCTTTTGCAATGGTGTTTT	0.483													29	150					0	0	0	0	G	140165875	G	G	140165875	1	3	131	0	1	0	0	0	0	0	0	0	11573	145	5	5		5	PCDHA1	5	140165875	5'Flank	SNP	A	TCGA-CR-6487-01A-11D-1870-08	247323	140165875	40749385	49	23604											
PCDHGA1	56114	broad.mit.edu	37	chr5	140710925	140710925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaaccagtccgttcagggaCcctcagaatttacattcagg	11	10	9	11	1	3	2	3	1	0	1	4	3	4	3	3	2	2	1	3	2	3	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:140710925C>T	uc003lji.1	+	1	674	c.674C>T	c.(673-675)ACC>ATC	p.T225I	PCDHGA1_uc011dan.1_Missense_Mutation_p.T225I	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	225	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTTCAGGGACCCTCAGAATT	0.507													16	49					0	0	0	0	T	140710925	T	T	140710925	3	4	131	1	0	0	0	0	1	0	0	0	11604	507	18	4	676	4	PCDHGA1	5	140710925	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	545050	140710925	40204335	50	23605											
PCDHGA9	56107	broad.mit.edu	37	chr5	140782613	140782613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggccagggccagtcagattCgctactcagtgcctgaagag	10	7	13	11	1	2	3	2	1	0	2	3	3	2	3	3	2	2	1	3	2	2	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:140782613C>T	uc003lkh.1	+	1	94	c.94C>T	c.(94-96)CGC>TGC	p.R32C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.R32C	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	32	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTCAGATTCGCTACTCAGT	0.602													14	69					0	0	0	0	T	140782613	T	T	140782613	3	4	131	1	0	0	0	0	1	0	0	0	11615	884	31	1	96	1	PCDHGA9	5	140782613	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	71688	140782613	40132647	51	23606											
DIAPH1	1729	broad.mit.edu	37	chr5	140903714	140903714	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgtgcttacttaccttgAcggggccctctcttccgtcg	4	13	9	15	3	1	1	0	1	1	0	4	1	2	1	4	2	3	1	4	2	2	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:140903714A>G	uc003llb.3	-	28	3798	c.3657T>C	c.(3655-3657)CGT>CGC	p.R1219R	DIAPH1_uc011dbd.1_Silent_p.R113R|DIAPH1_uc003llc.3_Silent_p.R1210R	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	1219	DAD.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTTACCTTGACGGGGCCCTC	0.532													14	65					0	0	0	0	G	140903714	G	G	140903714	2	3	131	1	0	0	0	0	0	0	0	1	4540	262	10	5		5	DIAPH1	5	140903714	Silent	SNP	A	TCGA-CR-6487-01A-11D-1870-08	121101	140903714	40011546	52	23607											
PCDH1	5097	broad.mit.edu	37	chr5	141248480	141248480	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagccagcgggatggggaagAgtgagccgatgttggtgttc	9	8	18	6	2	0	2	0	1	0	1	1	5	0	4	2	4	3	2	2	4	2	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:141248480A>C	uc003llq.2	-	2	674	c.557T>G	c.(556-558)CTC>CGC	p.L186R	PCDH1_uc003llp.2_Missense_Mutation_p.L186R|PCDH1_uc011dbf.1_Missense_Mutation_p.L164R	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	186	Extracellular (Potential).|Cadherin 2.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GATGGGGAAGAGTGAGCCGAT	0.572													46	204					0	0	0	0	C	141248480	C	C	141248480	3	2	131	1	0	0	0	0	1	0	0	0	11560	304	11	5	3256	5	PCDH1	5	141248480	Missense_Mutation	SNP	A	TCGA-CR-6487-01A-11D-1870-08	344766	141248480	39666780	53	23608											
GRIA1	2890	broad.mit.edu	37	chr5	153149822	153149822	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacagaggaggggatgattcGagtgaggaaatccaaaggca	15	5	15	6	1	0	3	0	2	0	1	2	7	1	6	1	5	0	1	1	5	2	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr5:153149822G>A	uc003lva.3	+	13	2482	c.2117G>A	c.(2116-2118)CGA>CAA	p.R706Q	GRIA1_uc003luy.3_Missense_Mutation_p.R706Q|GRIA1_uc003luz.3_Missense_Mutation_p.R611Q|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.R626Q|GRIA1_uc011dcx.1_Missense_Mutation_p.R637Q|GRIA1_uc011dcy.1_Missense_Mutation_p.R716Q|GRIA1_uc011dcz.1_Missense_Mutation_p.R716Q	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	706	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGGATGATTCGAGTGAGGAAA	0.483													14	47					0	0	0	0	A	153149822	A	A	153149822	3	1	131	1	0	0	0	0	1	0	0	0	6806	1058	37	1	2167	1	GRIA1	5	153149822	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	11901342	153149822	27765438	54	23609											
RPP40	10799	broad.mit.edu	37	chr6	4998960	4998960	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttcctcatacctgttttatgCcaagccaaaagaaaatcaaa	16	11	4	10	0	2	1	2	0	0	1	3	1	3	1	4	0	3	1	4	0	8	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:4998960C>T	uc003mwl.2	-	5	584	c.549G>A	c.(547-549)TGG>TGA	p.W183*	RPP40_uc003mwm.2_Nonsense_Mutation_p.W160*	NM_006638	NP_006629	O75818	RPP40_HUMAN	ribonuclease P 40kDa subunit	183					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0895)				CTGTTTTATGCCAAGCCAAAA	0.299													4	21					0	0	0	0	T	4998960	T	T	4998960	4	4	131	1	0	0	0	0	0	1	0	0	13679	740	26	4	558	4	RPP40	6	4998960	Nonsense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08		4998960	166116107	55	23610											
FARS2	10667	broad.mit.edu	37	chr6	5369231	5369231	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcaggaagaagggggacaActattacctgaatcggactc	14	6	12	9	1	0	2	0	1	0	1	2	5	0	5	1	4	3	1	1	4	6	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:5369231A>G	uc010jnv.1	+	2	764	c.428A>G	c.(427-429)AAC>AGC	p.N143S	FARS2_uc003mwr.2_Missense_Mutation_p.N143S|FARS2_uc003mws.1_Missense_Mutation_p.N143S	NM_006567	NP_006558	O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2 precursor	143					phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	AAGGGGGACAACTATTACCTG	0.567													10	74					0	0	0	0	G	5369231	G	G	5369231	3	3	131	1	0	0	0	0	1	0	0	0	5710	43	2	5	430	5	FARS2	6	5369231	Missense_Mutation	SNP	A	TCGA-CR-6487-01A-11D-1870-08	370271	5369231	165745836	56	23611											
RREB1	6239	broad.mit.edu	37	chr6	7229769	7229769	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attctgaagatggcagcctcGgctccccctcagatcagtct	8	10	9	14	1	4	3	2	1	2	2	6	3	5	3	3	2	1	2	3	2	1	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:7229769G>A	uc003mxc.2	+	10	1827	c.1437G>A	c.(1435-1437)TCG>TCA	p.S479S	RREB1_uc003mxb.2_Silent_p.S479S|RREB1_uc010jnx.2_Silent_p.S479S	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	479					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TGGCAGCCTCGGCTCCCCCTC	0.607													26	208					0	0	0	0	A	7229769	A	A	7229769	2	1	131	1	0	0	0	0	0	0	0	1	13744	1103	39	1		1	RREB1	6	7229769	Silent	SNP	G	TCGA-CR-6487-01A-11D-1870-08	1860538	7229769	163885298	57	23612											
MAK	4117	broad.mit.edu	37	chr6	10770373	10770373	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcattgagaggtgctaagTggatcctctggccagctgac	8	11	13	9	0	1	2	0	2	1	1	2	4	2	3	2	3	3	3	2	3	1	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:10770373T>C	uc003mzl.2	-	12	1917	c.1688A>G	c.(1687-1689)CAC>CGC	p.H563R	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_RNA|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Missense_Mutation_p.H563R	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	563					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				AGGTGCTAAGTGGATCCTCTG	0.398													17	90					0	0	0	0	C	10770373	C	C	10770373	3	2	131	1	0	0	0	0	1	0	0	0	9250	1696	59	5	191	5	MAK	6	10770373	Missense_Mutation	SNP	T	TCGA-CR-6487-01A-11D-1870-08	3540604	10770373	160344694	58	23613											
MLN	4295	broad.mit.edu	37	chr6	33768873	33768873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatggggacgaaggcttccGtctgggaggccagcatggca	9	6	17	9	2	1	1	0	0	1	1	2	4	2	3	2	6	1	3	2	6	1	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:33768873G>A	uc003off.1	-	2	139	c.68C>T	c.(67-69)ACG>ATG	p.T23M	MLN_uc003ofg.1_Missense_Mutation_p.T23M|MLN_uc011drn.1_Missense_Mutation_p.T23M	NM_002418	NP_002409	P12872	MOTI_HUMAN	motilin isoform 1 preproprotein	23					cell-cell signaling|G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	hormone activity				0						GAAGGCTTCCGTCTGGGAGGC	0.577													18	102					0	0	0	0	A	33768873	A	A	33768873	3	1	131	1	0	0	0	0	1	0	0	0	9684	1145	40	1	295	1	MLN	6	33768873	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	22998500	33768873	137346194	59	23614											
C6orf89	221477	broad.mit.edu	37	chr6	36882411	36882411	+	Frame_Shift_Del	DEL	T	-	-																															cagaaggcttctctgaagggTttttcgccaagtggtggcgc																										TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:36882411delT	uc003omx.2	+	6	921	c.637delT	c.(637-639)TTTfs	p.F213fs	C6orf89_uc003omv.2_Frame_Shift_Del_p.F107fs|C6orf89_uc003omw.2_Frame_Shift_Del_p.F220fs|C6orf89_uc011dtr.1_Frame_Shift_Del_p.F107fs|C6orf89_uc003omy.2_Frame_Shift_Del_p.F47fs	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	213						integral to membrane				ovary(1)	1						CTCTGAAGGGTTTTTCGCCAA	0.448													---	---	---								-	36882411	-	-	36882411	7	5	131	1	0	1	0	1	0	0	0	0	2383	1725	60	0	676	0	C6orf89	6	36882411	Frame_Shift_Del	DEL	T	TCGA-CR-6487-01A-11D-1870-08	3113538	36882411	134232656	60	23615											
KIF6	221458	broad.mit.edu	37	chr6	39513399	39513399	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgaactttacgcatatccGcgccaacctctaatctactg	11	11	6	13	3	2	1	0	1	2	0	3	2	3	1	3	0	4	1	3	0	6	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:39513399G>A	uc003oot.2	-	11	1342	c.1247C>T	c.(1246-1248)GCG>GTG	p.A416V	KIF6_uc010jxa.1_Missense_Mutation_p.A207V|KIF6_uc011dua.1_Missense_Mutation_p.A416V|KIF6_uc010jxb.1_Missense_Mutation_p.A416V	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	416					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						ACGCATATCCGCGCCAACCTC	0.363													7	83					0	0	0	0	A	39513399	A	A	39513399	3	1	131	1	0	0	0	0	1	0	0	0	8347	1087	38	1	1249	1	KIF6	6	39513399	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	2630988	39513399	131601668	61	23616											
LRFN2	57497	broad.mit.edu	37	chr6	40360590	40360590	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catggccagcacacacaagtCgtagccagtccctgacacca	12	5	8	16	1	0	1	0	1	0	0	2	1	1	1	4	1	2	2	4	1	2	1	rs55706368		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:40360590C>T	uc003oph.1	-	3	1927	c.1462G>A	c.(1462-1464)GAC>AAC	p.D488N		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	488	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					ACACACAAGTCGTAGCCAGTC	0.597													4	27					0	0	0	0	T	40360590	T	T	40360590	3	4	131	1	0	0	0	0	1	0	0	0	8988	884	31	1	911	1	LRFN2	6	40360590	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	847191	40360590	130754477	62	23617											
MDN1	23195	broad.mit.edu	37	chr6	90426527	90426528	+	Frame_Shift_Del	DEL	CT	-	-																															tcttcaacaagtttggcaaaCtctgaaatgtcacagggaag																										TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr6:90426527_90426528delCT	uc003pnn.1	-	44	6700_6701	c.6584_6585delAG	c.(6583-6585)GAGfs	p.E2195fs		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2195					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTTTGGCAAACTCTGAAATGTC	0.421													---	---	---								-	90426528	-	-	90426527	7	5	131	1	0	1	0	1	0	0	0	0	9468	579	20	0	10441	0	MDN1	6	90426527	Frame_Shift_Del	DEL	CT	TCGA-CR-6487-01A-11D-1870-08	50065937	90426527	80688540	63	23618											
CCDC129	223075	broad.mit.edu	37	chr7	31692184	31692184	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactattcaaatctgcatcAatataactggatagaagaaa	19	10	5	7	0	3	2	2	0	1	2	3	3	3	3	0	1	2	1	0	1	8	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr7:31692184A>G	uc003tcj.1	+	14	3869	c.2876A>G	c.(2875-2877)CAA>CGA	p.Q959R	CCDC129_uc011kad.1_Missense_Mutation_p.Q969R|CCDC129_uc003tci.1_Missense_Mutation_p.Q810R|CCDC129_uc011kae.1_Missense_Mutation_p.Q985R|CCDC129_uc003tck.1_Missense_Mutation_p.Q867R	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	959											0						AATCTGCATCAATATAACTGG	0.468													3	16					0	0	0	0	G	31692184	G	G	31692184	3	3	131	1	0	0	0	0	1	0	0	0	2776	130	5	5	2926	5	CCDC129	7	31692184	Missense_Mutation	SNP	A	TCGA-CR-6487-01A-11D-1870-08		31692184	127446479	64	23619											
NRF1	4899	broad.mit.edu	37	chr7	129367082	129367082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgttcctgtgcccgcagcGaagctgccgcccatgctgtc	4	9	11	17	3	0	0	0	0	0	0	2	1	1	0	5	0	5	4	5	0	1	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr7:129367082G>A	uc003voz.2	+	10	1342	c.1225G>A	c.(1225-1227)GAA>AAA	p.E409K	NRF1_uc003vpa.2_Missense_Mutation_p.E409K|NRF1_uc011kpa.1_Missense_Mutation_p.E248K|NRF1_uc003vpb.2_Missense_Mutation_p.E409K	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	409	Required for transcriptional activation.				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						TGCCCGCAGCGAAGCTGCCGC	0.577													5	38					0	0	0	0	A	129367082	A	A	129367082	3	1	131	1	0	0	0	0	1	0	0	0	10700	1072	37	1	1259	1	NRF1	7	129367082	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	97674898	129367082	29771581	65	23620											
POLR3D	661	broad.mit.edu	37	chr8	22106636	22106636	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccaggaagactccaggcctCccgaaggatgtatctgtggc	9	7	13	12	1	1	1	0	0	1	1	3	4	3	3	4	4	0	1	4	4	3	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:22106636C>T	uc003xbl.2	+	7	818	c.735C>T	c.(733-735)CTC>CTT	p.L245L	POLR3D_uc003xbm.2_Silent_p.L245L|POLR3D_uc011kze.1_Intron	NM_001722	NP_001713	P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	245					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity				0				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CTCCAGGCCTCCCGAAGGATG	0.592													4	39					0	0	0	0	T	22106636	T	T	22106636	2	4	131	1	0	0	0	0	0	0	0	1	12286	842	30	2		2	POLR3D	8	22106636	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08		22106636	124257386	66	23621											
ADAM32	203102	broad.mit.edu	37	chr8	39022696	39022696	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcttaacctaaggcctcatGatattgcatatctactaatg	13	14	5	9	0	3	1	1	1	2	0	3	1	3	1	2	1	3	1	2	1	6	7			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:39022696G>A	uc003xmt.3	+	9	1059	c.814G>A	c.(814-816)GAT>AAT	p.D272N	ADAM32_uc011lch.1_Missense_Mutation_p.D279N|ADAM32_uc003xmu.3_Missense_Mutation_p.D272N	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	272	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			AAGGCCTCATGATATTGCATA	0.289													5	27					0	0	0	0	A	39022696	A	A	39022696	3	1	131	1	0	0	0	0	1	0	0	0	249	1290	45	2	848	2	ADAM32	8	39022696	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	16916060	39022696	107341326	67	23622											
RP1	6101	broad.mit.edu	37	chr8	55542592	55542592	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgggtaatgtggattcaaaTacacaagacctcagcggtca	13	9	11	8	1	3	1	3	0	0	1	3	2	3	2	1	3	2	1	1	3	4	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:55542592T>C	uc003xsd.1	+	4	6298	c.6150T>C	c.(6148-6150)AAT>AAC	p.N2050N	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	2050					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGGATTCAAATACACAAGACC	0.338													6	46					0	0	0	0	C	55542592	C	C	55542592	2	2	131	1	0	0	0	0	0	0	0	1	13597	1403	49	5		5	RP1	8	55542592	Silent	SNP	T	TCGA-CR-6487-01A-11D-1870-08	16519896	55542592	90821430	68	23623											
MMP16	4325	broad.mit.edu	37	chr8	89180146	89180146	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgccacacatcaaaggcaCggcgaatagctttacgagtc	12	8	9	12	3	2	0	1	0	1	0	3	2	2	0	1	2	3	2	1	2	4	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:89180146C>T	uc003yeb.3	-	4	743	c.461G>A	c.(460-462)CGT>CAT	p.R154H	MMP16_uc003yec.2_Missense_Mutation_p.R154H	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	154	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						ATCAAAGGCACGGCGAATAGC	0.368													7	46					0	0	0	0	T	89180146	T	T	89180146	3	4	131	1	0	0	0	0	1	0	0	0	9708	536	19	1	1546	1	MMP16	8	89180146	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	33637554	89180146	57183876	69	23624											
PKHD1L1	93035	broad.mit.edu	37	chr8	110456922	110456922	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agctacccctgtgtcgtagaAgaaagtagtgaggattcaat	13	10	11	7	1	1	3	1	1	0	2	2	4	1	4	2	1	2	3	2	1	6	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:110456922A>T	uc003yne.2	+	38	4928	c.4824A>T	c.(4822-4824)GAA>GAT	p.E1608D		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1608	Extracellular (Potential).|IPT/TIG 8.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTGTCGTAGAAGAAAGTAGTG	0.358										HNSCC(38;0.096)			81	210					0	0	0	0	T	110456922	T	T	110456922	3	4	131	1	0	0	0	0	1	0	0	0	12027	69	3	5	4974	5	PKHD1L1	8	110456922	Missense_Mutation	SNP	A	TCGA-CR-6487-01A-11D-1870-08	21276776	110456922	35907100	70	23625											
CSMD3	114788	broad.mit.edu	37	chr8	113960032	113960032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atattacctaaaatctgatcCgattctcttcccattttctg	10	17	3	11	1	3	1	0	1	3	0	6	2	5	1	3	0	1	0	3	0	4	7			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:113960032C>T	uc003ynu.2	-	9	1654	c.1495G>A	c.(1495-1497)GGA>AGA	p.G499R	CSMD3_uc003ynt.2_Missense_Mutation_p.G459R|CSMD3_uc011lhx.1_Missense_Mutation_p.G395R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	499	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAATCTGATCCGATTCTCTTC	0.294										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	60					0	0	0	0	T	113960032	T	T	113960032	3	4	131	1	0	0	0	0	1	0	0	0	3963	661	23	1	9880	1	CSMD3	8	113960032	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	3503110	113960032	32403990	71	23626											
DENND3	22898	broad.mit.edu	37	chr8	142178285	142178285	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atttgtacctccgagggctcGtttatctgatgcagggacag	8	12	12	9	2	1	1	0	1	1	0	3	3	2	2	2	2	2	4	2	2	2	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr8:142178285G>A	uc003yvy.2	+	13	1974	c.1696G>A	c.(1696-1698)GTT>ATT	p.V566I	DENND3_uc010mep.2_Missense_Mutation_p.V527I|DENND3_uc003yvz.1_Missense_Mutation_p.V250I	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	566										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CCGAGGGCTCGTTTATCTGAT	0.522													14	152					0	0	0	0	A	142178285	A	A	142178285	3	1	131	1	0	0	0	0	1	0	0	0	4454	1145	40	1	1742	1	DENND3	8	142178285	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	28218253	142178285	4185737	72	23627											
C9orf135	138255	broad.mit.edu	37	chr9	72521027	72521027	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagaaactctatcccttgaCtagtgggcctattgtgccaa	11	11	8	11	0	1	2	0	1	1	1	2	2	2	2	3	1	2	0	3	1	5	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:72521027C>T	uc004ahl.2	+	6	730	c.665C>T	c.(664-666)ACT>ATT	p.T222I	C9orf135_uc011lrw.1_3'UTR|C9orf135_uc010moq.2_Missense_Mutation_p.T114I|C9orf135_uc011lrx.1_RNA|C9orf135_uc010mop.2_3'UTR	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255	222	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						TATCCCTTGACTAGTGGGCCT	0.338													12	64					0	0	0	0	T	72521027	T	T	72521027	3	4	131	1	0	0	0	0	1	0	0	0	2470	565	20	4	687	4	C9orf135	9	72521027	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08		72521027	68692404	73	23628											
SLC44A1	23446	broad.mit.edu	37	chr9	108151336	108151336	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcgggagcaagttctgcttGaacctagccgacggttatgg	8	11	13	9	3	1	1	0	1	1	0	2	3	1	2	2	3	4	4	2	3	4	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:108151336G>C	uc004bcn.2	+	16	2194	c.1973G>C	c.(1972-1974)TGA>TCA	p.*658S	SLC44A1_uc010mtk.1_Intron|SLC44A1_uc004bco.1_Intron	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	658						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	AGTTCTGCTTGAACCTAGCCG	0.279													33	149					0	0	0	0	C	108151336	C	C	108151336	4	2	131	1	0	0	0	0	0	0	0	0	14699	1285	45	2	2035	2	SLC44A1	9	108151336	Nonstop_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	35630309	108151336	33062095	74	23629											
RGS3	5998	broad.mit.edu	37	chr9	116353615	116353615	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtcttctctccgcagatGagcggggctgacaccgttgg	5	11	13	12	3	3	3	0	2	3	1	5	3	4	3	2	3	1	3	2	3	0	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:116353615G>T	uc004bhq.2	+	22	3227	c.3018G>T	c.(3016-3018)ATG>ATT	p.M1006I	RGS3_uc004bhs.2_Missense_Mutation_p.M896I|RGS3_uc004bht.2_Missense_Mutation_p.M725I|RGS3_uc010muy.2_Missense_Mutation_p.M399I|RGS3_uc004bhv.2_Missense_Mutation_p.M327I|RGS3_uc010muz.1_Missense_Mutation_p.M345I|RGS3_uc004bhw.2_Intron|RGS3_uc011lxh.1_Missense_Mutation_p.M316I|RGS3_uc004bhx.2_Missense_Mutation_p.M327I|RGS3_uc004bhy.1_Missense_Mutation_p.M316I|RGS3_uc004bhz.2_Missense_Mutation_p.M348I|RGS3_uc004bia.2_5'Flank	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	1006					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						CTCCGCAGATGAGCGGGGCTG	0.572													8	52					3.09899e-07	3.20524e-07	1	0	T	116353615	T	T	116353615	3	4	131	1	0	0	0	0	1	0	0	0	13371	1290	45	2	3353	2	RGS3	9	116353615	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	8202279	116353615	24859816	75	23630											
OR1J4	26219	broad.mit.edu	37	chr9	125282179	125282179	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgtctctgtattatggcAcaattattggactgtatttt	8	19	9	5	0	1	0	0	0	1	0	2	1	1	1	0	3	0	3	0	3	5	7			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:125282179A>G	uc011lyw.1	+	1	760	c.760A>G	c.(760-762)ACA>GCA	p.T254A		NM_001004452	NP_001004452	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTATTATGGCACAATTATTGG	0.493													16	70					0	0	0	0	G	125282179	G	G	125282179	3	3	131	1	0	0	0	0	1	0	0	0	11015	159	6	5	762	5	OR1J4	9	125282179	Missense_Mutation	SNP	A	TCGA-CR-6487-01A-11D-1870-08	8928564	125282179	15931252	76	23631											
C9orf167	54863	broad.mit.edu	37	chr9	140174030	140174030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttccacaacgccatctacGtgctcctcagtggcgcgggt	7	9	10	15	4	2	0	1	0	1	0	4	0	4	0	3	2	3	1	3	2	2	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:140174030G>A	uc004cmn.2	+	2	1006	c.889G>A	c.(889-891)GTG>ATG	p.V297M	C9orf167_uc011mew.1_5'Flank	NM_017723	NP_060193	Q9NXH8	CI167_HUMAN	hypothetical protein LOC54863	297					chaperone mediated protein folding requiring cofactor	integral to membrane	ATP binding|nucleoside-triphosphatase activity			pancreas(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.07e-05)|Epithelial(140;0.000728)		CGCCATCTACGTGCTCCTCAG	0.716													3	13					0	0	0	0	A	140174030	A	A	140174030	3	1	131	1	0	0	0	0	1	0	0	0	2480	1145	40	1	891	1	C9orf167	9	140174030	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	14891851	140174030	1039401	77	23632											
EHMT1	79813	broad.mit.edu	37	chr9	140657192	140657192	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgcctctctgcagctgcCggatggaaacaccgaagagt	11	7	12	11	2	1	1	0	0	1	1	2	4	1	3	3	2	5	2	3	2	3	0			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr9:140657192C>T	uc011mfc.1	+	10	1604	c.1567C>T	c.(1567-1569)CGG>TGG	p.R523W	EHMT1_uc004coa.2_Missense_Mutation_p.R523W|EHMT1_uc004cob.1_Missense_Mutation_p.R492W|FLJ40292_uc010nco.2_5'Flank	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	523					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CTGCAGCTGCCGGATGGAAAC	0.537													8	36					0	0	0	0	T	140657192	T	T	140657192	3	4	131	1	0	0	0	0	1	0	0	0	5005	643	23	1	1605	1	EHMT1	9	140657192	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	483162	140657192	556239	78	23633											
ITIH2	3698	broad.mit.edu	37	chr10	7774362	7774362	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgacttgcaggattttctatCgaaagacaagcatgcagatc	13	10	9	9	2	1	2	0	0	1	2	3	5	1	3	0	1	3	3	0	1	3	4	rs150529114		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:7774362C>T	uc001ijs.2	+	14	1871	c.1709C>T	c.(1708-1710)TCG>TTG	p.S570L		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	570					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.S570L(1)		ovary(1)|pancreas(1)|skin(1)	3						GATTTTCTATCGAAAGACAAG	0.488													4	27					0	0	0	0	T	7774362	T	T	7774362	3	4	131	1	0	0	0	0	1	0	0	0	7943	893	31	1	1763	1	ITIH2	10	7774362	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08		7774362	127760385	79	23634											
RET	5979	broad.mit.edu	37	chr10	43606744	43606744	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctggtgccaactgcagcacGctaggggtggtcacctcagc	7	8	13	13	1	3	0	2	0	1	0	3	0	3	0	2	4	5	3	2	4	2	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:43606744G>A	uc001jal.2	+	7	1543	c.1353G>A	c.(1351-1353)ACG>ACA	p.T451T	RET_uc001jak.1_Silent_p.T451T|RET_uc010qez.1_Silent_p.T197T	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	451	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	ACTGCAGCACGCTAGGGGTGG	0.582		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				10	67					0	0	0	0	A	43606744	A	A	43606744	2	1	131	1	0	0	0	0	0	0	0	1	13300	1074	38	1		1	RET	10	43606744	Silent	SNP	G	TCGA-CR-6487-01A-11D-1870-08	35832382	43606744	91928003	80	23635											
POLR3A	11128	broad.mit.edu	37	chr10	79760814	79760814	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccactgatggcctgctgtcCcacacaggcaatcatctgtg	8	9	10	14	0	2	1	1	1	1	0	3	1	3	1	3	2	1	2	3	2	1	0			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:79760814C>A	uc001jzn.2	-	18	2492	c.2398G>T	c.(2398-2400)GGA>TGA	p.G800*		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	800					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GCCTGCTGTCCCACACAGGCA	0.443													9	57					0.00448238	0.00450728	1	0	A	79760814	A	A	79760814	4	1	131	1	0	0	0	0	0	1	0	0	12283	632	22	4	1830	4	POLR3A	10	79760814	Nonsense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	36154070	79760814	55773933	81	23636											
CEP55	55165	broad.mit.edu	37	chr10	95276830	95276830	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaaatatgaagaaacccAaaaagaagttcacaatttaa	24	7	5	5	0	1	4	1	1	0	3	1	4	1	4	1	0	1	1	1	0	11	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:95276830A>T	uc009xug.2	+	6	1000	c.818A>T	c.(817-819)CAA>CTA	p.Q273L	CEP55_uc001kiq.3_Missense_Mutation_p.Q273L	NM_001127182	NP_001120654	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	273	Potential.				cell division|mitosis	centriole|cleavage furrow|midbody					0		Colorectal(252;0.207)				GAAGAAACCCAAAAAGAAGTT	0.358													10	54					0	0	0	0	T	95276830	T	T	95276830	3	4	131	1	0	0	0	0	1	0	0	0	3270	130	5	5	836	5	CEP55	10	95276830	Missense_Mutation	SNP	A	TCGA-CR-6487-01A-11D-1870-08	15516016	95276830	40257917	82	23637											
PLCE1	51196	broad.mit.edu	37	chr10	95790868	95790868	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcagagaaaagtggtttctgCccagtcggctgcagatgaaa	12	9	12	8	1	2	3	1	1	1	2	3	4	2	3	1	2	2	3	1	2	3	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:95790868C>T	uc001kjk.2	+	2	699	c.65C>T	c.(64-66)GCC>GTC	p.A22V	PLCE1_uc010qnx.1_Missense_Mutation_p.A22V	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	22					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GTGGTTTCTGCCCAGTCGGCT	0.423													3	51					0	0	0	0	T	95790868	T	T	95790868	3	4	131	1	0	0	0	0	1	0	0	0	12089	739	26	4	67	4	PLCE1	10	95790868	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	514038	95790868	39743879	83	23638											
FAM178A	55719	broad.mit.edu	37	chr10	102683830	102683830	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctatgataccaaaagcaagaGagtccttccttgagaagcgt	14	9	9	9	1	0	3	0	2	0	2	2	5	2	3	3	0	3	1	3	0	6	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:102683830G>C	uc001krt.3	+	5	1614	c.1072G>C	c.(1072-1074)GAG>CAG	p.E358Q	FAM178A_uc001krr.1_Missense_Mutation_p.E358Q|FAM178A_uc001krs.2_Missense_Mutation_p.E358Q|FAM178A_uc001kru.1_Missense_Mutation_p.E293Q	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	358											0						AAAAGCAAGAGAGTCCTTCCT	0.398													9	48					0	0	0	0	C	102683830	C	C	102683830	3	2	131	1	0	0	0	0	1	0	0	0	5531	943	33	2	1090	2	FAM178A	10	102683830	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	6892962	102683830	32850917	84	23639											
POLL	27343	broad.mit.edu	37	chr10	103339236	103339236	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcccgctcagcaggttctcGgtaggggaggcctaagagcc	7	7	15	12	2	2	1	1	0	1	1	4	2	3	2	3	5	2	4	3	5	2	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:103339236G>A	uc001ktg.1	-	8	2468	c.1702C>T	c.(1702-1704)CGA>TGA	p.R568*	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_Nonsense_Mutation_p.R241*|POLL_uc001kte.1_Nonsense_Mutation_p.R260*|POLL_uc001kth.1_Nonsense_Mutation_p.R293*|POLL_uc001kti.1_Nonsense_Mutation_p.R568*|POLL_uc001ktj.1_Nonsense_Mutation_p.R568*|POLL_uc001ktf.2_Nonsense_Mutation_p.R476*|POLL_uc001ktk.1_Nonsense_Mutation_p.R307*|POLL_uc010qqa.1_Nonsense_Mutation_p.R307*|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Nonsense_Mutation_p.R568*|POLL_uc001ktl.2_Nonsense_Mutation_p.R480*|POLL_uc010qqc.1_Nonsense_Mutation_p.R260*	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	568					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GCAGGTTCTCGGTAGGGGAGG	0.647								DNA_polymerases_(catalytic_subunits)					14	49					0	0	0	0	A	103339236	A	A	103339236	4	1	131	1	0	0	0	0	0	1	0	0	12260	1124	39	1	29	1	POLL	10	103339236	Nonsense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	655406	103339236	32195511	85	23640											
ADAM12	8038	broad.mit.edu	37	chr10	127726869	127726869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttccaaggtggccgaggtGagcctgacagggttggaagc	8	9	16	8	1	0	2	0	2	0	0	1	4	1	3	3	5	2	1	3	5	2	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr10:127726869G>A	uc001ljk.2	-	20	2712	c.2299C>T	c.(2299-2301)CAC>TAC	p.H767Y	ADAM12_uc010qul.1_Missense_Mutation_p.H718Y	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	767	Cytoplasmic (Potential).				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		TGGCCGAGGTGAGCCTGACAG	0.587													3	18					0	0	0	0	A	127726869	A	A	127726869	3	1	131	1	0	0	0	0	1	0	0	0	236	1290	45	2	446	2	ADAM12	10	127726869	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	24387633	127726869	7807878	86	23641											
OR51V1	283111	broad.mit.edu	37	chr11	5221401	5221401	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaggatgtggaaatgacagTaattaaaaaatttcagacag	20	9	9	3	0	1	2	1	1	0	1	1	4	1	4	0	2	0	1	0	2	6	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:5221401T>A	uc010qyz.1	-	1	530	c.530A>T	c.(529-531)TAC>TTC	p.Y177F		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAATGACAGTAATTAAAAAA	0.393													18	64					0	0	0	0	A	5221401	A	A	5221401	3	1	131	1	0	0	0	0	1	0	0	0	11161	1638	57	5	438	5	OR51V1	11	5221401	Missense_Mutation	SNP	T	TCGA-CR-6487-01A-11D-1870-08		5221401	129785115	87	23642											
APBB1	322	broad.mit.edu	37	chr11	6432243	6432243	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagagtacaggtgtatcaggCctttggggcccaagggtgcc	8	8	15	10	0	1	1	1	0	0	1	1	1	1	1	3	5	2	2	3	5	3	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:6432243C>T	uc001mdb.1	-	2	435	c.335G>A	c.(334-336)GGC>GAC	p.G112D	APBB1_uc001mdc.1_Missense_Mutation_p.G112D|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	112					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GTGTATCAGGCCTTTGGGGCC	0.632													45	182					0	0	0	0	T	6432243	T	T	6432243	3	4	131	1	0	0	0	0	1	0	0	0	759	739	26	4	1849	4	APBB1	11	6432243	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	1210842	6432243	128574273	88	23643											
USP47	55031	broad.mit.edu	37	chr11	11971469	11971469	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctagatgctgtgtttgctAaaggaatgactgtacggcaa	11	12	12	6	1	0	2	0	1	0	1	0	3	0	3	0	2	4	6	0	2	6	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:11971469A>G	uc001mjs.2	+	23	4145	c.3382A>G	c.(3382-3384)AAA>GAA	p.K1128E	USP47_uc001mjr.2_Missense_Mutation_p.K1060E|USP47_uc009ygi.2_5'Flank	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	1148					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TGTGTTTGCTAAAGGAATGAC	0.338													6	36					0	0	0	0	G	11971469	G	G	11971469	3	3	131	1	0	0	0	0	1	0	0	0	17146	363	13	5	3264	5	USP47	11	11971469	Missense_Mutation	SNP	A	TCGA-CR-6487-01A-11D-1870-08	5539226	11971469	123035047	89	23644			1	34		2	2	16	N	C_A	7.316404e-05
USP47	55031	broad.mit.edu	37	chr11	11971484	11971484	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgctaaaggaatgactgtaCggcaatcaaaagaggaatta	17	9	10	5	1	1	2	1	1	0	1	1	4	1	4	0	3	2	3	0	3	9	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:11971484C>T	uc001mjs.2	+	23	4160	c.3397C>T	c.(3397-3399)CGG>TGG	p.R1133W	USP47_uc001mjr.2_Missense_Mutation_p.R1065W|USP47_uc009ygi.2_5'Flank	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	1153					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		AATGACTGTACGGCAATCAAA	0.358													7	37					0	0	0	0	T	11971484	T	T	11971484	3	4	131	1	0	0	0	0	1	0	0	0	17146	527	19	1	3279	1	USP47	11	11971484	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	15	11971484	123035032	90	23645			1	34		2	2	16	N	C_A	7.316404e-05
MICALCL	84953	broad.mit.edu	37	chr11	12345523	12345523	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttctccattggttttcatAggagaagaagacacttagaa	13	14	8	6	0	2	4	1	0	1	4	3	5	2	4	1	2	0	1	1	2	5	7			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:12345523A>G	uc001mkg.1	+	5	1834	c.1543_splice	c.e5-2	p.E515_splice		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		TGGTTTTCATAGGAGAAGAAG	0.353													3	77					0	0	0	0	G	12345523	G	G	12345523	5	3	131	1	0	0	0	0	0	0	1	0	9625	434	15	5	1555	5	MICALCL	11	12345523	Splice_Site	SNP	A	TCGA-CR-6487-01A-11D-1870-08	374039	12345523	122660993	91	23646											
PIK3C2A	5286	broad.mit.edu	37	chr11	17140215	17140215	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tataaattgtgtgctatctgGatatttcccaatgccctgga	10	15	8	8	0	1	0	0	0	1	0	2	2	2	2	2	2	2	1	2	2	6	6			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:17140215G>T	uc001mmq.3	-	17	3078	c.3012C>A	c.(3010-3012)ATC>ATA	p.I1004I	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Silent_p.I624I|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1004					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	GTGCTATCTGGATATTTCCCA	0.289													29	120					7.01153e-11	7.33577e-11	1	0	T	17140215	T	T	17140215	2	4	131	1	0	0	0	0	0	0	0	1	11964	1164	41	2		2	PIK3C2A	11	17140215	Silent	SNP	G	TCGA-CR-6487-01A-11D-1870-08	4794692	17140215	117866301	92	23647											
USH1C	10083	broad.mit.edu	37	chr11	17548829	17548829	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggttgatgacctcctcatggGtacaggaggagatggaatat	11	10	14	6	0	1	3	1	2	0	1	2	6	2	5	2	5	1	2	2	5	3	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:17548829G>A	uc001mnf.2	-	5	546	c.437C>T	c.(436-438)ACC>ATC	p.T146I	USH1C_uc001mne.2_Missense_Mutation_p.T146I|USH1C_uc009yhb.2_Missense_Mutation_p.T146I|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Missense_Mutation_p.T110I	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	146	PDZ 1.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						CTCCTCATGGGTACAGGAGGA	0.522													13	68					0	0	0	0	A	17548829	A	A	17548829	3	1	131	1	0	0	0	0	1	0	0	0	17102	1261	44	4	2432	4	USH1C	11	17548829	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	408614	17548829	117457687	93	23648											
OR5L2	26338	broad.mit.edu	37	chr11	55594821	55594821	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtcacgttgttagccaatCtgggcatgactgcactgatt	9	12	11	9	1	2	2	1	2	1	0	2	3	2	2	1	1	2	4	1	1	2	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:55594821C>T	uc001nhy.1	+	1	127	c.127C>T	c.(127-129)CTG>TTG	p.L43L		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				GTTAGCCAATCTGGGCATGAC	0.498										HNSCC(27;0.073)			63	247					0	0	0	0	T	55594821	T	T	55594821	2	4	131	1	0	0	0	0	0	0	0	1	11225	912	32	2		2	OR5L2	11	55594821	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	38045992	55594821	79411695	94	23649											
OR5D16	390144	broad.mit.edu	37	chr11	55606633	55606633	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaatcctctgctctacacaGttgccatctcccagaaactc	10	10	5	16	0	3	1	0	0	3	1	6	1	4	1	3	0	4	3	3	0	3	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:55606633G>A	uc010rio.1	+	1	406	c.406G>A	c.(406-408)GTT>ATT	p.V136I		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				GCTCTACACAGTTGCCATCTC	0.453													20	83					0	0	0	0	A	55606633	A	A	55606633	3	1	131	1	0	0	0	0	1	0	0	0	11210	1029	36	4	408	4	OR5D16	11	55606633	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	11812	55606633	79399883	95	23650											
MMP13	4322	broad.mit.edu	37	chr11	102816405	102816405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagacagcatctactttatCaccaattcctgggaagtctt	12	13	6	10	0	3	1	1	0	2	1	4	2	4	2	2	1	2	1	2	1	5	6			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:102816405C>T	uc001phl.2	-	9	1313	c.1285G>A	c.(1285-1287)GAT>AAT	p.D429N		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	429	Hemopexin-like 3.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TCTACTTTATCACCAATTCCT	0.338													17	58					0	0	0	0	T	102816405	T	T	102816405	3	4	131	1	0	0	0	0	1	0	0	0	9705	826	29	2	138	2	MMP13	11	102816405	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	47209772	102816405	32190111	96	23651											
ARHGAP20	57569	broad.mit.edu	37	chr11	110450902	110450902	+	Frame_Shift_Del	DEL	A	-	-																															aaaggtttaatcttgggggtAaaaccttctcagtgttttgg																										TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:110450902delA	uc001pkz.1	-	16	3053	c.2768delT	c.(2767-2769)TTAfs	p.L923fs	ARHGAP20_uc001pky.1_Frame_Shift_Del_p.L900fs|ARHGAP20_uc009yyb.1_Frame_Shift_Del_p.L887fs|ARHGAP20_uc001pla.1_Frame_Shift_Del_p.L887fs|ARHGAP20_uc001plb.2_Frame_Shift_Del_p.L466fs	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	923					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCTTGGGGGTAAAACCTTCTC	0.493													---	---	---								-	110450902	-	-	110450902	7	5	131	1	0	1	0	1	0	0	0	0	870	372	13	0	811	0	ARHGAP20	11	110450902	Frame_Shift_Del	DEL	A	TCGA-CR-6487-01A-11D-1870-08	7634497	110450902	24555614	97	23652											
OR6M1	390261	broad.mit.edu	37	chr11	123676380	123676380	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgacggccctgggtggaGgggatacgcaggatggtaga	8	8	18	7	2	1	2	0	1	1	1	1	5	1	5	1	7	1	2	1	7	2	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr11:123676380G>A	uc010rzz.1	-	1	678	c.678C>T	c.(676-678)CCC>CCT	p.P226P		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CCTGGGTGGAGGGGATACGCA	0.498													5	21					0	0	0	0	A	123676380	A	A	123676380	2	1	131	1	0	0	0	0	0	0	0	1	11259	987	35	4		4	OR6M1	11	123676380	Silent	SNP	G	TCGA-CR-6487-01A-11D-1870-08	13225478	123676380	11330136	98	23653											
PARP11	57097	broad.mit.edu	37	chr12	3931108	3931108	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taattcggttgcgatccatcGtcttcccaaagagattagca	11	12	8	10	3	1	1	0	0	1	1	5	3	3	1	2	1	2	2	2	1	3	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:3931108G>A	uc001qmk.1	-	5	513	c.458C>T	c.(457-459)ACG>ATG	p.T153M	PARP11_uc001qml.2_Missense_Mutation_p.T160M|PARP11_uc009zef.2_RNA|PARP11_uc001qmm.2_Missense_Mutation_p.T79M|PARP11_uc001qmn.2_Missense_Mutation_p.T79M	NM_020367	NP_065100	Q9NR21	PAR11_HUMAN	poly (ADP-ribose) polymerase family, member 11	153	PARP catalytic.						NAD+ ADP-ribosyltransferase activity			ovary(1)|central_nervous_system(1)	2			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)			GCGATCCATCGTCTTCCCAAA	0.348													19	72					0	0	0	0	A	3931108	A	A	3931108	3	1	131	1	0	0	0	0	1	0	0	0	11510	1145	40	1	549	1	PARP11	12	3931108	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08		3931108	129920787	99	23654											
IFFO1	25900	broad.mit.edu	37	chr12	6664531	6664531	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcccaccccatccgggtgcAcccacgacaagccaggccct	8	3	9	21	3	0	0	0	0	0	0	1	1	1	0	7	2	2	1	7	2	1	0			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:6664531A>G	uc001qpd.1	-	1	699	c.665T>C	c.(664-666)GTG>GCG	p.V222A	IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_Missense_Mutation_p.V222A|IFFO1_uc001qpf.1_Missense_Mutation_p.V222A|IFFO1_uc001qpc.1_Missense_Mutation_p.V222A	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	222						intermediate filament					0						ATCCGGGTGCACCCACGACAA	0.682													9	50					0	0	0	0	G	6664531	G	G	6664531	3	3	131	1	0	0	0	0	1	0	0	0	7549	159	6	5	1066	5	IFFO1	12	6664531	Missense_Mutation	SNP	A	TCGA-CR-6487-01A-11D-1870-08	2733423	6664531	127187364	100	23655											
GPR162	27239	broad.mit.edu	37	chr12	6933294	6933294	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccgtggtgcagctgcgtcGtcaggcttcctccgactatg	4	11	13	13	4	1	0	1	0	0	0	4	1	3	0	3	2	4	3	3	2	1	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:6933294G>A	uc001qqw.1	+	2	765	c.230G>A	c.(229-231)CGT>CAT	p.R77H	GPR162_uc010sfn.1_Missense_Mutation_p.R77H|GPR162_uc001qqx.1_Intron|GPR162_uc009zfd.1_Intron|GPR162_uc001qqy.1_5'Flank	NM_019858	NP_062832	Q16538	GP162_HUMAN	G protein-coupled receptor 162 isoform 2	77	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAGCTGCGTCGTCAGGCTTCC	0.602													11	62					0	0	0	0	A	6933294	A	A	6933294	3	1	131	1	0	0	0	0	1	0	0	0	6704	1145	40	1	251	1	GPR162	12	6933294	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	268763	6933294	126918601	101	23656											
RAPGEF3	10411	broad.mit.edu	37	chr12	48131465	48131465	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggtgctcagggactgctccGagcctggtggaggagagtag	7	7	19	8	1	1	1	1	0	0	1	2	5	2	3	2	5	3	3	2	5	1	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:48131465G>A	uc009zkp.2	-	27	2971	c.2531C>T	c.(2530-2532)TCG>TTG	p.S844L	uc001rpv.2_Intron|RAPGEF3_uc001rpw.2_Missense_Mutation_p.S179L|RAPGEF3_uc001rpx.2_Missense_Mutation_p.S301L|RAPGEF3_uc010sln.1_Missense_Mutation_p.S341L|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Missense_Mutation_p.S844L|RAPGEF3_uc001rpz.3_Missense_Mutation_p.S886L	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	844					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GGACTGCTCCGAGCCTGGTGG	0.602													8	25					0	0	0	0	A	48131465	A	A	48131465	3	1	131	1	0	0	0	0	1	0	0	0	13110	1059	37	1	118	1	RAPGEF3	12	48131465	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	41198171	48131465	85720430	102	23657											
MLL2	8085	broad.mit.edu	37	chr12	49438595	49438595	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcagggccaagggcatctGagggctcagaaccctccaat	11	6	11	13	0	3	2	2	1	1	1	4	2	4	2	3	3	1	2	3	3	3	0			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:49438595G>C	uc001rta.3	-	19	4895	c.4895C>G	c.(4894-4896)TCA>TGA	p.S1632*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1632					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AAGGGCATCTGAGGGCTCAGA	0.607			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			17	58					0	0	0	0	C	49438595	C	C	49438595	4	2	131	1	0	0	0	0	0	1	0	0	9674	1294	45	2	11862	2	MLL2	12	49438595	Nonsense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	1307130	49438595	84413300	103	23658											
MLL2	8085	broad.mit.edu	37	chr12	49448693	49448693	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacaagctacctgcagtcctGaggagtctcctgaagcctgg	10	8	11	12	0	1	2	0	2	1	0	3	3	2	3	4	2	5	2	4	2	4	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:49448693G>A	uc001rta.3	-	2	166	c.166C>T	c.(166-168)CAG>TAG	p.Q56*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	56					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTGCAGTCCTGAGGAGTCTCC	0.522			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			40	139					0	0	0	0	A	49448693	A	A	49448693	4	1	131	1	0	0	0	0	0	1	0	0	9674	1299	45	2	16659	2	MLL2	12	49448693	Nonsense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	10098	49448693	84403202	104	23659											
SMARCD1	6602	broad.mit.edu	37	chr12	50480110	50480110	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcaggtccagcagcaggCggtccaaaatcgaaaccaca	14	3	10	14	2	0	0	0	0	0	0	3	1	2	0	4	3	4	3	4	3	3	0			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:50480110C>T	uc001rvx.3	+	2	514	c.344C>T	c.(343-345)GCG>GTG	p.A115V	SMARCD1_uc010smo.1_Missense_Mutation_p.A115V|SMARCD1_uc001rvy.3_Missense_Mutation_p.A115V|SMARCD1_uc009zlp.2_Missense_Mutation_p.A115V	NM_003076	NP_003067	Q96GM5	SMRD1_HUMAN	SWI/SNF-related matrix-associated	115	Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4.				chromatin-mediated maintenance of transcription|nervous system development|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	protein complex scaffold|transcription coactivator activity			ovary(1)	1						CAGCAGCAGGCGGTCCAAAAT	0.617													7	24					0	0	0	0	T	50480110	T	T	50480110	3	4	131	1	0	0	0	0	1	0	0	0	14841	768	27	1	350	1	SMARCD1	12	50480110	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	1031417	50480110	83371785	105	23660											
CCDC64	92558	broad.mit.edu	37	chr12	120510422	120510422	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacggactcctccatggaCgagtcttcagaaacctcgtc	9	9	8	15	3	2	1	1	0	1	1	7	4	5	3	4	2	1	0	4	2	1	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:120510422C>T	uc001txl.1	+	6	1222	c.1197C>T	c.(1195-1197)GAC>GAT	p.D399D	CCDC64_uc001txk.2_Silent_p.D399D|CCDC64_uc009zwv.1_Intron|CCDC64_uc010sze.1_Intron|CCDC64_uc010szf.1_Silent_p.D48D	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	399					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCTCCATGGACGAGTCTTCAG	0.572													13	50					0	0	0	0	T	120510422	T	T	120510422	2	4	131	1	0	0	0	0	0	0	0	1	2848	535	19	1		1	CCDC64	12	120510422	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	70030312	120510422	13341473	106	23661											
MLEC	9761	broad.mit.edu	37	chr12	121125205	121125205	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggctcggcgtggccggcGtggccggcgcggcgggggcc	0	3	23	15	9	0	0	0	0	0	0	1	0	0	0	4	9	0	1	4	9	0	0			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr12:121125205G>A	uc001tyy.1	+	1	257	c.106G>A	c.(106-108)GTG>ATG	p.V36M		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	36	Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						CGTggccggcgtggccggcgc	0.478													4	6					0	0	0	0	A	121125205	A	A	121125205	3	1	131	1	0	0	0	0	1	0	0	0	9666	1145	40	1	108	1	MLEC	12	121125205	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	614783	121125205	12726690	107	23662											
RB1	5925	broad.mit.edu	37	chr13	48954379	48954379	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtaatggccacatatagcagTaagttaaattttcataaata	17	13	6	5	0	1	0	1	0	0	0	1	0	1	0	1	1	1	4	1	1	9	9			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr13:48954379T>G	uc001vcb.2	+	16	1664	c.1498_splice	c.e16+2	p.R500_splice		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CATATAGCAGTAAGTTAAATT	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			4	10					0	0	0	0	G	48954379	G	G	48954379	5	3	131	1	0	0	0	0	0	0	1	0	13163	1652	57	5	1562	5	RB1	13	48954379	Splice_Site	SNP	T	TCGA-CR-6487-01A-11D-1870-08		48954379	66215499	108	23663											
PCCA	5095	broad.mit.edu	37	chr13	100915005	100915005	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggttttagattgtcatctCaagaagctgcttctagtttt	9	18	8	6	0	3	2	2	0	2	2	4	2	3	2	0	1	2	4	0	1	4	7			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr13:100915005C>G	uc001voo.2	+	10	777	c.739C>G	c.(739-741)CAA>GAA	p.Q247E	PCCA_uc010aga.2_Missense_Mutation_p.Q221E|PCCA_uc010tiz.1_Missense_Mutation_p.Q247E	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	247	ATP-grasp.|Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	ATTGTCATCTCAAGAAGCTGC	0.264													30	136					0	0	0	0	G	100915005	G	G	100915005	3	3	131	1	0	0	0	0	1	0	0	0	11558	827	29	2	777	2	PCCA	13	100915005	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	51960626	100915005	14254873	109	23664											
PSMA6	5687	broad.mit.edu	37	chr14	35786477	35786477	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttacagaagcagagattGatgctcaccttgttgctcta	10	14	8	9	0	3	3	1	1	2	2	3	4	3	3	1	0	4	4	1	0	3	6			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:35786477G>C	uc001wtd.2	+	7	815	c.706G>C	c.(706-708)GAT>CAT	p.D236H	KIAA0391_uc001wta.2_RNA|PSMA6_uc010tpt.1_Missense_Mutation_p.D157H|PSMA6_uc010tpu.1_Missense_Mutation_p.D157H	NM_002791	NP_002782	P60900	PSA6_HUMAN	proteasome alpha 6 subunit	236					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nuclear matrix|polysome|proteasome core complex, alpha-subunit complex|sarcomere	NF-kappaB binding|purine ribonucleoside triphosphate binding|RNA binding|threonine-type endopeptidase activity				0	Breast(36;0.0519)|Hepatocellular(127;0.158)		Lung(238;3.81e-05)|LUAD - Lung adenocarcinoma(48;5.59e-05)|Epithelial(34;0.00342)|all cancers(34;0.00973)	GBM - Glioblastoma multiforme(112;0.0234)		AGCAGAGATTGATGCTCACCT	0.323													29	131					0	0	0	0	C	35786477	C	C	35786477	3	2	131	1	0	0	0	0	1	0	0	0	12733	1290	45	2	732	2	PSMA6	14	35786477	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08		35786477	71563063	110	23665											
ZFYVE26	23503	broad.mit.edu	37	chr14	68252948	68252948	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtacgtggtctatccgtcGacctggaaatagatgaagga	12	9	13	7	3	1	2	0	1	1	1	3	6	2	4	2	3	1	1	2	3	5	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:68252948G>A	uc001xka.2	-	17	3161	c.3022C>T	c.(3022-3024)CGA>TGA	p.R1008*	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Nonsense_Mutation_p.R1008*	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1008					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCTATCCGTCGACCTGGAAAT	0.388													8	19					0	0	0	0	A	68252948	A	A	68252948	4	1	131	1	0	0	0	0	0	1	0	0	17735	1066	37	1	4701	1	ZFYVE26	14	68252948	Nonsense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	32466471	68252948	39096592	111	23666											
PCNX	22990	broad.mit.edu	37	chr14	71493536	71493536	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttcattggtctcctgcctCaggtgaatacatttgtaatg	8	17	8	8	0	3	1	2	1	1	0	4	1	3	1	2	2	2	1	2	2	3	6			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:71493536C>T	uc001xmo.2	+	15	3849	c.3403C>T	c.(3403-3405)CAG>TAG	p.Q1135*	PCNX_uc010are.1_Nonsense_Mutation_p.Q1024*|PCNX_uc010arf.1_5'UTR	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1135						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TCTCCTGCCTCAGGTGAATAC	0.284													14	64					0	0	0	0	T	71493536	T	T	71493536	4	4	131	1	0	0	0	0	0	1	0	0	11645	827	29	2	3461	2	PCNX	14	71493536	Nonsense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	3240588	71493536	35856004	112	23667											
VSX2	338917	broad.mit.edu	37	chr14	74726405	74726405	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctctacggggccatggtgcGgcactccatccccctgcccg	4	7	12	18	3	1	0	0	0	1	0	3	0	3	0	5	4	3	2	5	4	1	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:74726405G>A	uc001xpq.2	+	4	770	c.680G>A	c.(679-681)CGG>CAG	p.R227Q		NM_182894	NP_878314	P58304	VSX2_HUMAN	visual system homeobox 2	227	CVC.		R -> W (in MCOP2).		multicellular organismal development|response to stimulus|visual perception	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00154)		GCCATGGTGCGGCACTCCATC	0.637													12	56					0	0	0	0	A	74726405	A	A	74726405	3	1	131	1	0	0	0	0	1	0	0	0	17300	1116	39	1	694	1	VSX2	14	74726405	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	3232869	74726405	32623135	113	23668											
TDP1	55775	broad.mit.edu	37	chr14	90433740	90433740	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctttgacgtggactggctCgtaaaacagtatccaccaga	11	10	10	10	2	0	2	0	1	0	1	2	3	1	3	2	2	2	4	2	2	3	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:90433740C>T	uc001xxy.2	+	5	932	c.633C>T	c.(631-633)CTC>CTT	p.L211L	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Silent_p.L211L|TDP1_uc010atn.2_Silent_p.L211L|TDP1_uc001xya.2_5'UTR|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Silent_p.L211L	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	211					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGGACTGGCTCGTAAAACAGT	0.408								Repair_of_DNA-protein_crosslinks					18	81					0	0	0	0	T	90433740	T	T	90433740	2	4	131	1	0	0	0	0	0	0	0	1	15794	871	31	1		1	TDP1	14	90433740	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	15707335	90433740	16915800	114	23669											
KCNK13	56659	broad.mit.edu	37	chr14	90650902	90650902	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggcctctatcgctttgccaActtcgtcttcatcctcatgg	6	14	7	14	2	4	0	2	0	2	0	7	0	5	0	3	2	2	1	3	2	2	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:90650902A>G	uc001xye.1	+	2	1224	c.782A>G	c.(781-783)AAC>AGC	p.N261S		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	261						integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				CGCTTTGCCAACTTCGTCTTC	0.493													23	81					0	0	0	0	G	90650902	G	G	90650902	3	3	131	1	0	0	0	0	1	0	0	0	8100	43	2	5	788	5	KCNK13	14	90650902	Missense_Mutation	SNP	A	TCGA-CR-6487-01A-11D-1870-08	217162	90650902	16698638	115	23670											
ATG2B	55102	broad.mit.edu	37	chr14	96783566	96783566	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagagttcttgttctgagaGtctaatttttttttcctgcg	6	20	9	6	1	3	2	0	2	3	2	4	4	4	2	1	0	1	2	1	0	1	8			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr14:96783566G>A	uc001yfi.2	-	20	3491	c.3126C>T	c.(3124-3126)GAC>GAT	p.D1042D		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1042										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TGTTCTGAGAGTCTAATTTTT	0.373													12	60					0	0	0	0	A	96783566	A	A	96783566	2	1	131	1	0	0	0	0	0	0	0	1	1096	1020	36	4		4	ATG2B	14	96783566	Silent	SNP	G	TCGA-CR-6487-01A-11D-1870-08	6132664	96783566	10565974	116	23671											
ADAM10	102	broad.mit.edu	37	chr15	58925416	58925416	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggatccaaagttatgtccAacttcgtgagcaaaagtaat	14	10	10	7	1	0	1	0	1	0	0	3	2	2	2	2	2	2	3	2	2	6	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr15:58925416A>G	uc002afd.1	-	9	1599	c.1155T>C	c.(1153-1155)GTT>GTC	p.V385V	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Silent_p.V84V|ADAM10_uc002afe.1_Intron	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	385	Peptidase M12B.|Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		AGTTATGTCCAACTTCGTGAG	0.323													13	29					0	0	0	0	G	58925416	G	G	58925416	2	3	131	1	0	0	0	0	0	0	0	1	234	117	5	5		5	ADAM10	15	58925416	Silent	SNP	A	TCGA-CR-6487-01A-11D-1870-08		58925416	43605976	117	23672											
MYO1E	4643	broad.mit.edu	37	chr15	59455404	59455404	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgggtcttctcctcgtaaCgctttgctaagaggcttagg	6	14	11	10	2	3	1	0	0	3	1	5	1	3	1	1	3	2	4	1	3	3	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr15:59455404C>T	uc002aga.2	-	23	2951	c.2579G>A	c.(2578-2580)CGT>CAT	p.R860H		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	860					actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		CTCCTCGTAACGCTTTGCTAA	0.433													7	27					0	0	0	0	T	59455404	T	T	59455404	3	4	131	1	0	0	0	0	1	0	0	0	10125	536	19	1	771	1	MYO1E	15	59455404	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	529988	59455404	43075988	118	23673											
SRRM2	23524	broad.mit.edu	37	chr16	2816182	2816182	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaacccccctgataagcCgacgtaggtccagatctcga	11	6	9	15	3	1	3	0	1	1	2	3	5	2	3	6	1	2	1	6	1	3	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr16:2816182C>T	uc002crk.2	+	11	6202	c.5653C>T	c.(5653-5655)CGA>TGA	p.R1885*	SRRM2_uc002crj.1_Nonsense_Mutation_p.R1789*|SRRM2_uc002crl.1_Nonsense_Mutation_p.R1885*|SRRM2_uc010bsu.1_Nonsense_Mutation_p.R1789*	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1885	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCTGATAAGCCGACGTAGGTC	0.592													9	49					0	0	0	0	T	2816182	T	T	2816182	4	4	131	1	0	0	0	0	0	1	0	0	15235	644	23	1	5691	1	SRRM2	16	2816182	Nonsense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08		2816182	87538571	119	23674											
PLEKHG4	25894	broad.mit.edu	37	chr16	67318623	67318623	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggtgttgcaggccttgaCgtgggctgaggaggggcagc	5	8	19	9	1	0	2	0	2	0	0	0	3	0	3	2	6	2	4	2	6	0	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr16:67318623C>T	uc002eso.3	+	12	4235	c.1700C>T	c.(1699-1701)ACG>ATG	p.T567M	PLEKHG4_uc002esp.3_Missense_Mutation_p.T374M|PLEKHG4_uc002esq.3_Missense_Mutation_p.T567M|PLEKHG4_uc010cef.2_Missense_Mutation_p.T567M|PLEKHG4_uc002ess.3_Missense_Mutation_p.T567M|PLEKHG4_uc010ceg.2_Missense_Mutation_p.T486M	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	567					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CAGGCCTTGACGTGGGCTGAG	0.448													6	27					0	0	0	0	T	67318623	T	T	67318623	3	4	131	1	0	0	0	0	1	0	0	0	12126	536	19	1	1746	1	PLEKHG4	16	67318623	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	64502441	67318623	23036130	120	23675											
NFAT5	10725	broad.mit.edu	37	chr16	69703948	69703948	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcagtgaaaggagaagaaGaagtgtttttaatcggcaag	15	10	13	3	1	1	4	1	1	0	3	2	5	1	4	0	2	0	3	0	2	6	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr16:69703948G>A	uc002exm.1	+	7	2592	c.1384G>A	c.(1384-1386)GAA>AAA	p.E462K	NFAT5_uc002exh.1_Missense_Mutation_p.E256K|NFAT5_uc002exi.2_Missense_Mutation_p.E386K|NFAT5_uc002exj.1_Missense_Mutation_p.E386K|NFAT5_uc002exk.1_Missense_Mutation_p.E386K|NFAT5_uc002exl.1_Missense_Mutation_p.E480K|NFAT5_uc002exn.1_Missense_Mutation_p.E480K	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	462					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AGGAGAAGAAGAAGTGTTTTT	0.363													8	38					0	0	0	0	A	69703948	A	A	69703948	3	1	131	1	0	0	0	0	1	0	0	0	10414	943	33	2	1468	2	NFAT5	16	69703948	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	2385325	69703948	20650805	121	23676											
LDHD	197257	broad.mit.edu	37	chr16	75146543	75146543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgaccctgcccagttcctCggcgtcatcagggttgacca	6	10	10	15	2	2	2	2	2	0	0	4	2	3	2	4	2	1	2	4	2	0	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr16:75146543C>T	uc002fdm.2	-	10	1362	c.1315G>A	c.(1315-1317)GAG>AAG	p.E439K	LDHD_uc002fdn.2_Missense_Mutation_p.E416K	NM_153486	NP_705690	Q86WU2	LDHD_HUMAN	D-lactate dehydrogenase isoform 1 precursor	439							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding				0						CCCAGTTCCTCGGCGTCATCA	0.602													10	39					0	0	0	0	T	75146543	T	T	75146543	3	4	131	1	0	0	0	0	1	0	0	0	8743	893	31	1	216	1	LDHD	16	75146543	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	5442595	75146543	15208210	122	23677											
VMO1	284013	broad.mit.edu	37	chr17	4688867	4688867	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcgctgctgtgttgtcaccGagggtcgtgggtgcctccac	3	12	14	12	3	1	0	1	0	0	0	4	1	2	0	3	2	2	3	3	2	0	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:4688867G>A	uc002fyx.2	-	3	481	c.399C>T	c.(397-399)CTC>CTT	p.L133L	VMO1_uc010vsh.1_3'UTR|VMO1_uc010vsi.1_3'UTR|VMO1_uc002fyy.2_3'UTR	NM_182566	NP_872372	Q7Z5L0	VMO1_HUMAN	vitelline membrane outer layer 1 isoform 1	133					vitelline membrane formation	extracellular region				ovary(1)	1						TGTTGTCACCGAGGGTCGTGG	0.642													6	23					0	0	0	0	A	4688867	A	A	4688867	2	1	131	1	0	0	0	0	0	0	0	1	17245	1045	37	1		1	VMO1	17	4688867	Silent	SNP	G	TCGA-CR-6487-01A-11D-1870-08		4688867	76506343	123	23678											
CCT6B	10693	broad.mit.edu	37	chr17	33288392	33288392	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccacctcagccttggagttGacggcctttatcgcagccat	7	10	10	14	2	1	1	1	1	0	0	2	2	1	2	5	2	2	2	5	2	1	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:33288392G>C	uc002hig.2	-	1	115	c.21C>G	c.(19-21)GTC>GTG	p.V7V	CCT6B_uc010ctg.2_Silent_p.V7V|CCT6B_uc010wcc.1_Silent_p.V7V|ZNF830_uc002hih.3_5'Flank	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	7					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				CCTTGGAGTTGACGGCCTTTA	0.572													4	48					0	0	0	0	C	33288392	C	C	33288392	2	2	131	1	0	0	0	0	0	0	0	1	2973	1277	45	2		2	CCT6B	17	33288392	Silent	SNP	G	TCGA-CR-6487-01A-11D-1870-08	28599525	33288392	47906818	124	23679											
C17orf66	256957	broad.mit.edu	37	chr17	34190080	34190080	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcctttgaccctcatttttCtccttcagctgtttgatgag	6	18	6	11	0	3	3	2	3	1	0	5	3	4	3	3	0	1	2	3	0	0	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:34190080C>G	uc002hke.1	-	8	824	c.675G>C	c.(673-675)GAG>GAC	p.E225D	C17orf66_uc010wck.1_RNA|C17orf66_uc010wcl.1_Missense_Mutation_p.E185D|C17orf66_uc010wcm.1_Missense_Mutation_p.E191D	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957	225							binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		CCTCATTTTTCTCCTTCAGCT	0.537													20	104					0	0	0	0	G	34190080	G	G	34190080	3	3	131	1	0	0	0	0	1	0	0	0	1881	912	32	2	1069	2	C17orf66	17	34190080	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	901688	34190080	47005130	125	23680											
ABCC3	8714	broad.mit.edu	37	chr17	48750428	48750428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggatgacccactgtccGcggtggactctcatgtggcc	5	10	13	13	2	1	1	1	1	1	0	3	3	2	3	3	4	1	1	3	4	0	0			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:48750428G>A	uc002isl.2	+	18	2418	c.2338G>A	c.(2338-2340)GCG>ACG	p.A780T		NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	780	ABC transporter 1.|Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCCACTGTCCGCGGTGGACTC	0.602													13	46					0	0	0	0	A	48750428	A	A	48750428	3	1	131	1	0	0	0	0	1	0	0	0	54	1087	38	1	2492	1	ABCC3	17	48750428	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	14560348	48750428	32444782	126	23681											
TEX2	55852	broad.mit.edu	37	chr17	62238187	62238187	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgccaatttctccaaccttCagggcttcaacaagaggctc	10	11	7	13	0	3	1	2	0	1	1	5	1	3	1	3	2	3	2	3	2	4	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr17:62238187C>T	uc002jec.2	-	8	2951	c.2778G>A	c.(2776-2778)CTG>CTA	p.L926L	TEX2_uc002jed.2_Silent_p.L933L|TEX2_uc002jee.2_Silent_p.L926L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	926					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CTCCAACCTTCAGGGCTTCAA	0.443													54	213					0	0	0	0	T	62238187	T	T	62238187	2	4	131	1	0	0	0	0	0	0	0	1	15847	813	29	2		2	TEX2	17	62238187	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	13487759	62238187	18957023	127	23682											
MC2R	4158	broad.mit.edu	37	chr18	13884716	13884716	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggggtcaatgacggcatTgcacatgatcaacatgccgt	12	8	12	9	2	2	2	2	2	0	0	2	3	2	2	1	3	3	2	1	3	3	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr18:13884716T>A	uc002ksp.1	-	2	979	c.802A>T	c.(802-804)AAT>TAT	p.N268Y		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	268	Helical; Name=7; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	ATGACGGCATTGCACATGATC	0.502													23	69					0	0	0	0	A	13884716	A	A	13884716	3	1	131	1	0	0	0	0	1	0	0	0	9417	1812	63	5	95	5	MC2R	18	13884716	Missense_Mutation	SNP	T	TCGA-CR-6487-01A-11D-1870-08		13884716	64192532	128	23683											
PQLC1	80148	broad.mit.edu	37	chr18	77664144	77664144	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaggaagtaggccgtcttGaaggcgtcaccactggtcca	10	7	13	11	2	2	1	1	1	1	0	3	2	3	2	3	4	1	2	3	4	3	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr18:77664144G>C	uc002lnl.2	-	6	820	c.648C>G	c.(646-648)TTC>TTG	p.F216L	PQLC1_uc010dre.2_Missense_Mutation_p.F133L|PQLC1_uc002lnk.2_Missense_Mutation_p.F198L|PQLC1_uc010xfm.1_Nonsense_Mutation_p.S126*	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	216	PQ-loop 2.					integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		AGGCCGTCTTGAAGGCGTCAC	0.647													14	20					0	0	0	0	C	77664144	C	C	77664144	3	2	131	1	0	0	0	0	1	0	0	0	12478	1294	45	2	171	2	PQLC1	18	77664144	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	63779428	77664144	413104	129	23684											
CHAF1A	10036	broad.mit.edu	37	chr19	4431980	4431980	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgagaaccataaggtccGccagaaactgaaggccaagg	14	4	11	12	1	0	3	0	2	0	2	1	4	1	3	5	3	2	0	5	3	5	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:4431980G>A	uc002mal.2	+	12	2079	c.1979G>A	c.(1978-1980)CGC>CAC	p.R660H		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	660	Necessary for homodimerization and competence for chromatin assembly.|Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CATAAGGTCCGCCAGAAACTG	0.562								Chromatin_Structure					4	112					0	0	0	0	A	4431980	A	A	4431980	3	1	131	1	0	0	0	0	1	0	0	0	3326	1087	38	1	2025	1	CHAF1A	19	4431980	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08		4431980	54697003	130	23685											
ISYNA1	51477	broad.mit.edu	37	chr19	18546719	18546719	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccaggtggttgtaactcaCgatggacatggtctgtgggt	7	11	15	8	1	2	0	1	0	1	0	2	2	2	1	1	5	1	2	1	5	1	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:18546719C>T	uc002njd.1	-	8	1038	c.988G>A	c.(988-990)GTG>ATG	p.V330M	ISYNA1_uc002nja.1_Missense_Mutation_p.V202M|ISYNA1_uc002njb.1_Missense_Mutation_p.V248M|ISYNA1_uc002njc.1_Missense_Mutation_p.V180M|ISYNA1_uc010xqh.1_Missense_Mutation_p.V128M|ISYNA1_uc002nje.1_Missense_Mutation_p.V276M|ISYNA1_uc002njf.1_Missense_Mutation_p.V180M	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	330					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2						TTGTAACTCACGATGGACATG	0.622													40	160					0	0	0	0	T	18546719	T	T	18546719	3	4	131	1	0	0	0	0	1	0	0	0	7906	536	19	1	704	1	ISYNA1	19	18546719	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	14114739	18546719	40582264	131	23686											
AXL	558	broad.mit.edu	37	chr19	41765694	41765694	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcctgtagctgcctcactgCggctgaggtccatcctgctg	4	12	11	14	1	1	1	1	1	0	0	4	1	4	1	4	2	4	4	4	2	1	2	rs61737385		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:41765694C>T	uc010ehj.2	+	20	2760	c.2570C>T	c.(2569-2571)GCG>GTG	p.A857V	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_5'Flank|HNRNPUL1_uc002oqa.3_5'Flank|AXL_uc010ehk.2_Missense_Mutation_p.A848V|HNRNPUL1_uc010ehl.1_5'Flank	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	857	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						TGCCTCACTGCGGCTGAGGTC	0.637													7	42					0	0	0	0	T	41765694	T	T	41765694	3	4	131	1	0	0	0	0	1	0	0	0	1240	768	27	1	2648	1	AXL	19	41765694	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	23218975	41765694	17363289	132	23687											
IRF2BP1	26145	broad.mit.edu	37	chr19	46388584	46388584	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccaagcaaggcccttcgcGccccctcagccacggcctcc	7	4	9	21	3	1	0	1	0	0	0	3	0	2	0	7	2	3	1	7	2	2	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:46388584G>A	uc002pds.1	-	1	793	c.449C>T	c.(448-450)GCG>GTG	p.A150V		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		GGCCCTTCGCGCCCCCTCAGC	0.716													6	16					0	0	0	0	A	46388584	A	A	46388584	3	1	131	1	0	0	0	0	1	0	0	0	7868	1087	38	1	1309	1	IRF2BP1	19	46388584	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	4622890	46388584	12740399	133	23688											
KLK3	354	broad.mit.edu	37	chr19	51361366	51361366	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttcaggtcagccacagcttCccacacccgctctacgatat	9	10	6	16	2	3	0	2	0	1	0	4	1	4	0	3	1	3	2	3	1	2	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:51361366C>A	uc002pts.1	+	3	329	c.288C>A	c.(286-288)TTC>TTA	p.F96L	KLK3_uc010ycj.1_Missense_Mutation_p.F96L|KLK3_uc002ptr.1_Intron|KLK3_uc010eof.1_Intron	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	96	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		GCCACAGCTTCCCACACCCGC	0.577													13	41					1.49906e-05	1.52432e-05	1	0	A	51361366	A	A	51361366	3	1	131	1	0	0	0	0	1	0	0	0	8444	854	30	2	302	2	KLK3	19	51361366	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	4972782	51361366	7767617	134	23689											
ZNF320	162967	broad.mit.edu	37	chr19	53384034	53384034	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgaaggtgaattaaaggCtttaccacaatcaccacact	14	10	8	9	0	1	2	1	2	0	0	1	2	1	2	2	2	1	1	2	2	6	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:53384034C>T	uc002qag.2	-	4	1536	c.1345G>A	c.(1345-1347)GCC>ACC	p.A449T	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.A395T|ZNF320_uc002qai.2_Missense_Mutation_p.A449T	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	449	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		GAATTAAAGGCTTTACCACAA	0.403													6	65					0	0	0	0	T	53384034	T	T	53384034	3	4	131	1	0	0	0	0	1	0	0	0	17906	797	28	4	188	4	ZNF320	19	53384034	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	2022668	53384034	5744949	135	23690											
KIR3DL3	115653	broad.mit.edu	37	chr19	55239242	55239242	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgttggacagctccacgatgCgggttcccaggtcaactatt	8	10	11	12	3	1	0	1	0	0	0	3	2	3	1	2	3	3	3	2	3	2	4			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:55239242C>T	uc002qgu.1	+	4	539	c.521C>T	c.(520-522)GCG>GTG	p.A174V	KIR2DL3_uc002qgv.2_Intron	NM_153443	NP_703144	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three	174	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity	p.A174V(1)		ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		CTCCACGATGCGGGTTCCCAG	0.547													62	41					0	0	0	0	T	55239242	T	T	55239242	3	4	131	1	0	0	0	0	1	0	0	0	8361	768	27	1	535	1	KIR3DL3	19	55239242	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	1855208	55239242	3889741	136	23691											
NLRP4	147945	broad.mit.edu	37	chr19	56369057	56369057	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggatacacaaagacctatCaagctcacgcaaagcagaaa	19	4	7	11	1	2	2	2	0	0	2	2	3	2	3	1	1	3	3	1	1	6	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:56369057C>G	uc002qmd.3	+	3	720	c.298C>G	c.(298-300)CAA>GAA	p.Q100E	NLRP4_uc002qmf.2_Missense_Mutation_p.Q25E|NLRP4_uc010etf.2_Translation_Start_Site	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	100							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AAAGACCTATCAAGCTCACGC	0.423													17	74					0	0	0	0	G	56369057	G	G	56369057	3	3	131	1	0	0	0	0	1	0	0	0	10533	827	29	2	304	2	NLRP4	19	56369057	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	1129815	56369057	2759926	137	23692											
PEG3	5178	broad.mit.edu	37	chr19	57328787	57328787	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttatcatctgacattctgggGaatctctgtgaccggtcgct	7	14	10	10	2	4	2	1	2	3	0	6	3	4	3	1	3	0	1	1	3	2	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:57328787G>C	uc002qnu.2	-	7	1374	c.1023C>G	c.(1021-1023)TTC>TTG	p.F341L	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.F312L|PEG3_uc002qnv.2_Missense_Mutation_p.F341L|PEG3_uc002qnw.2_Missense_Mutation_p.F217L|PEG3_uc002qnx.2_Missense_Mutation_p.F215L|PEG3_uc010etr.2_Missense_Mutation_p.F341L	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	341					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACATTCTGGGGAATCTCTGTG	0.473													12	83					0	0	0	0	C	57328787	C	C	57328787	3	2	131	1	0	0	0	0	1	0	0	0	11774	1165	41	2	3747	2	PEG3	19	57328787	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08	959730	57328787	1800196	138	23693											
ZNF324B	388569	broad.mit.edu	37	chr19	58967762	58967762	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagaagcccttcgtgtgcaCgcagtgtggccgcgccttcc	5	8	13	15	5	0	1	0	0	0	1	2	2	1	1	4	1	2	2	4	1	1	2	rs143809080		TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr19:58967762C>T	uc002qsv.1	+	4	1558	c.1451C>T	c.(1450-1452)ACG>ATG	p.T484M	ZNF324B_uc002qsu.1_Missense_Mutation_p.T474M|ZNF324B_uc010euq.1_Missense_Mutation_p.T484M	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	484	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TTCGTGTGCACGCAGTGTGGC	0.672													11	62					0	0	0	0	T	58967762	T	T	58967762	3	4	131	1	0	0	0	0	1	0	0	0	17912	536	19	1	1461	1	ZNF324B	19	58967762	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	1638975	58967762	161221	139	23694											
PLCB1	23236	broad.mit.edu	37	chr20	8719969	8719969	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaagaaggaggtaaattcaTtggccaccgtatcttgccag	12	10	11	8	1	2	2	1	1	1	1	2	3	2	3	3	3	1	2	3	3	5	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr20:8719969T>C	uc002wnb.2	+	21	2273	c.2270T>C	c.(2269-2271)ATT>ACT	p.I757T	PLCB1_uc010zrb.1_Missense_Mutation_p.I656T|PLCB1_uc002wna.2_Missense_Mutation_p.I757T|PLCB1_uc002wnc.1_Missense_Mutation_p.I656T|PLCB1_uc002wnd.1_Missense_Mutation_p.I334T	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	757	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GGTAAATTCATTGGCCACCGT	0.418													13	69					0	0	0	0	C	8719969	C	C	8719969	3	2	131	1	0	0	0	0	1	0	0	0	12082	1493	52	5	2352	5	PLCB1	20	8719969	Missense_Mutation	SNP	T	TCGA-CR-6487-01A-11D-1870-08		8719969	54305551	140	23695											
RNF160	26046	broad.mit.edu	37	chr21	30303556	30303556	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttgaaaccgtgaatgactGagaaacagatcatgcaatct	16	9	9	7	1	2	5	1	4	1	2	2	6	2	5	1	0	3	2	1	0	4	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr21:30303556G>A	uc002ymr.2	-	29	5310	c.5297C>T	c.(5296-5298)TCA>TTA	p.S1766L		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1720	RING-type.						ligase activity|zinc ion binding				0						GTGAATGACTGAGAAACAGAT	0.363													14	61					0	0	0	0	A	30303556	A	A	30303556	3	1	131	1	0	0	0	0	1	0	0	0	13520	1294	45	2	149	2	RNF160	21	30303556	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08		30303556	17826339	141	23696											
TMEM50B	757	broad.mit.edu	37	chr21	34823152	34823152	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catagctcttcggttcttccAaatttgtagatcagagtgct	9	15	8	9	1	3	2	1	0	2	2	5	2	4	2	1	1	2	4	1	1	3	6			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr21:34823152A>G	uc002yrt.1	-	7	628	c.450T>C	c.(448-450)TTT>TTC	p.F150F	TMEM50B_uc002yrs.1_RNA|TMEM50B_uc010gmb.1_RNA	NM_006134	NP_006125	P56557	TM50B_HUMAN	transmembrane protein 50B	150						endoplasmic reticulum|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CGGTTCTTCCAAATTTGTAGA	0.348													13	40					0	0	0	0	G	34823152	G	G	34823152	2	3	131	1	0	0	0	0	0	0	0	1	16242	127	5	5		5	TMEM50B	21	34823152	Silent	SNP	A	TCGA-CR-6487-01A-11D-1870-08	4519596	34823152	13306743	142	23697											
DSCAM	1826	broad.mit.edu	37	chr21	41725414	41725414	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcacgtacaggcggcctatCaccttagcagttccgtatct	8	12	8	13	3	3	0	2	0	1	0	4	0	4	0	3	2	2	4	3	2	4	6			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr21:41725414C>T	uc002yyq.1	-	5	1364	c.912G>A	c.(910-912)GTG>GTA	p.V304V	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	304	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGCGGCCTATCACCTTAGCAG	0.502													28	152					0	0	0	0	T	41725414	T	T	41725414	2	4	131	1	0	0	0	0	0	0	0	1	4790	813	29	2		2	DSCAM	21	41725414	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	6902262	41725414	6404481	143	23698											
PRDM15	63977	broad.mit.edu	37	chr21	43221624	43221624	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agactgtgggttcgaggcttCcggctgggggtggatctgga	5	10	19	7	2	1	1	0	0	1	1	3	4	2	3	1	7	0	3	1	7	0	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr21:43221624C>A	uc002yzq.1	-	31	4411	c.4300G>T	c.(4300-4302)GAA>TAA	p.E1434*	PRDM15_uc002yzo.2_Nonsense_Mutation_p.E1105*|PRDM15_uc002yzp.2_Nonsense_Mutation_p.E1125*|PRDM15_uc002yzr.1_Nonsense_Mutation_p.E1125*	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCGAGGCTTCCGGCTGGGGG	0.587													12	53					2.32078e-09	2.41415e-09	1	0	A	43221624	A	A	43221624	4	1	131	1	0	0	0	0	0	1	0	0	12518	864	30	2	227	2	PRDM15	21	43221624	Nonsense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	1496210	43221624	4908271	144	23699											
NIPSNAP1	8508	broad.mit.edu	37	chr22	29966459	29966459	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggagtgggcatccttccggGgatccactttgtgaacaaag	9	10	13	9	1	0	1	0	1	0	0	3	3	3	3	3	4	1	1	3	4	2	2			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr22:29966459G>A	uc003afx.3	-	2	234	c.161C>T	c.(160-162)CCC>CTC	p.P54L	NIPSNAP1_uc011akp.1_Missense_Mutation_p.P34L	NM_003634	NP_003625	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1	54								p.?(1)		skin(1)	1						ATCCTTCCGGGGATCCACTTT	0.542													5	24					0	0	0	0	A	29966459	A	A	29966459	3	1	131	1	0	0	0	0	1	0	0	0	10483	1232	43	4	729	4	NIPSNAP1	22	29966459	Missense_Mutation	SNP	G	TCGA-CR-6487-01A-11D-1870-08		29966459	21338107	145	23700											
EP300	2033	broad.mit.edu	37	chr22	41531855	41531855	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaatggaggtgtaggagttCaaacgccgagtcttctttct	10	13	11	7	2	4	0	1	0	3	0	4	3	4	2	1	3	1	2	1	3	4	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr22:41531855C>T	uc003azl.3	+	7	1962	c.1567C>T	c.(1567-1569)CAA>TAA	p.Q523*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	523					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGTAGGAGTTCAAACGCCGAG	0.373			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				12	46					0	0	0	0	T	41531855	T	T	41531855	4	4	131	1	0	0	0	0	0	1	0	0	5172	827	29	2	1593	2	EP300	22	41531855	Nonsense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	11565396	41531855	9772711	146	23701											
SCUBE1	80274	broad.mit.edu	37	chr22	43610219	43610219	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catacatgacacacactggcCgagctcaccaccgaagtggg	12	5	10	14	2	1	1	1	1	0	0	1	3	1	1	3	2	2	1	3	2	2	1			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chr22:43610219C>T	uc003bdt.1	-	16	2018	c.1930G>A	c.(1930-1932)GGC>AGC	p.G644S		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	644					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				ACACACTGGCCGAGCTCACCA	0.642													3	48					0	0	0	0	T	43610219	T	T	43610219	3	4	131	1	0	0	0	0	1	0	0	0	14009	652	23	1	1064	1	SCUBE1	22	43610219	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	2078364	43610219	7694347	147	23702											
GAGE10	643832	broad.mit.edu	37	chrX	49158061	49158062	+	5'Flank	INS	-	T	T																															gtatgcagagacatcattccINSttttttttttttcttttttt																										TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chrX:49158061_49158062insT	uc010nir.1	+							NM_001098413	NP_001091883	A6NGK3	GAG10_HUMAN	G antigen 10												0	Ovarian(276;0.236)					gacatcattccttttttttttt	0													---	---	---								T	49158062	T	T	49158061	6	5	131	0	1	1	1	0	0	0	0	0	6221	696	24	0		0	GAGE10	23	49158061	5'Flank	INS	-	TCGA-CR-6487-01A-11D-1870-08		49158061	106112499	148	23703											
SMC1A	8243	broad.mit.edu	37	chrX	53426517	53426517	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttccttccttacctttttGagcttttctatctcattttc	4	23	2	12	0	2	1	1	1	2	0	6	1	4	1	3	0	2	1	3	0	2	10			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chrX:53426517G>A	uc004dsg.2	-	16	2625	c.2556C>T	c.(2554-2556)CTC>CTT	p.L852L	SMC1A_uc011moe.1_Silent_p.L830L	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	852	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						TTACCTTTTTGAGCTTTTCTA	0.333													13	28					0	0	0	0	A	53426517	A	A	53426517	2	1	131	1	0	0	0	0	0	0	0	1	14845	1277	45	2		2	SMC1A	23	53426517	Silent	SNP	G	TCGA-CR-6487-01A-11D-1870-08	4268456	53426517	101844043	149	23704											
WDR44	54521	broad.mit.edu	37	chrX	117527109	117527109	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacaaagaagcctgttccagCacgcccacctcctccaacta	12	7	5	17	1	0	1	0	0	0	1	3	1	3	1	6	0	4	2	6	0	5	3			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chrX:117527109C>T	uc004eqn.2	+	4	1126	c.701C>T	c.(700-702)GCA>GTA	p.A234V	WDR44_uc004eqo.2_Missense_Mutation_p.A234V|WDR44_uc011mtr.1_Missense_Mutation_p.A209V|WDR44_uc010nqi.2_5'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	234	Pro-rich.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						CCTGTTCCAGCACGCCCACCT	0.517													80	68					0	0	0	0	T	117527109	T	T	117527109	3	4	131	1	0	0	0	0	1	0	0	0	17364	710	25	4	715	4	WDR44	23	117527109	Missense_Mutation	SNP	C	TCGA-CR-6487-01A-11D-1870-08	64100592	117527109	37743451	150	23705											
AIFM1	9131	broad.mit.edu	37	chrX	129272623	129272623	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggaagcccccaccgataatCgtaattgatttgacttcccg	11	10	8	12	3	0	2	0	2	0	0	2	4	1	3	4	1	1	1	4	1	3	5			TCGA-CR-6487-01A-11D-1870-08	TCGA-CR-6487-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4df06d7-97e1-4f22-83a7-993fdcd3a4da	fc5e7544-cc5f-4877-b0c3-82221acd39b6	g.chrX:129272623C>T	uc004evg.2	-	9	1090	c.912G>A	c.(910-912)ACG>ACA	p.T304T	AIFM1_uc011mur.1_5'Flank|AIFM1_uc011mus.1_Silent_p.T304T|AIFM1_uc004evh.2_Silent_p.T300T|AIFM1_uc004evi.2_Intron|AIFM1_uc004evk.2_RNA	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	304	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5						CACCGATAATCGTAATTGATT	0.433													51	35					0	0	0	0	T	129272623	T	T	129272623	2	4	131	1	0	0	0	0	0	0	0	1	426	871	31	1		1	AIFM1	23	129272623	Silent	SNP	C	TCGA-CR-6487-01A-11D-1870-08	11745514	129272623	25997937	151	23706											
RLF	6018	broad.mit.edu	37	chr1	40703344	40703344	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagcccaaaaagataaagacGaaagatctgtttccctcttt	16	10	6	9	1	2	3	0	0	2	3	3	4	3	3	2	0	1	1	2	0	6	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr1:40703344G>A	uc001cfc.3	+	8	3001	c.2970G>A	c.(2968-2970)ACG>ACA	p.T990T	RLF_uc001cfd.3_Silent_p.T681T	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	990					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AGATAAAGACGAAAGATCTGT	0.408													12	55					0	0	0	0	A	40703344	A	A	40703344	2	1	132	1	0	0	0	0	0	0	0	1	13454	1045	37	1		1	RLF	1	40703344	Silent	SNP	G	TCGA-CR-6488-01A-12D-2078-08		40703344	208547277	1	23707											
HMCN1	83872	broad.mit.edu	37	chr1	186072800	186072800	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttcgaatttctactgctcaGgtaagtgtcaaagttcatag	11	14	8	8	1	4	0	3	0	1	0	5	1	4	0	0	1	2	3	0	1	5	6			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr1:186072800G>A	uc001grq.1	+	69	10999	c.10770G>A	c.(10768-10770)CAG>CAA	p.Q3590Q		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3590	Ig-like C2-type 34.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CTACTGCTCAGGTAAGTGTCA	0.393													7	30					0	0	0	0	A	186072800	A	A	186072800	2	1	132	1	0	0	0	0	0	0	0	1	7259	1014	35	4		4	HMCN1	1	186072800	Silent	SNP	G	TCGA-CR-6488-01A-12D-2078-08	145369456	186072800	63177821	2	23708											
WNT10A	80326	broad.mit.edu	37	chr2	219755048	219755048	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcacagagacatccacgCgagaatgaggcttcacaaca	14	5	9	13	2	2	3	2	1	0	2	3	5	3	3	2	1	1	1	2	1	2	1			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr2:219755048C>T	uc002vjd.1	+	3	1182	c.719C>T	c.(718-720)GCG>GTG	p.A240V		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	240					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GACATCCACGCGAGAATGAGG	0.617													6	31					0	0	0	0	T	219755048	T	T	219755048	3	4	132	1	0	0	0	0	1	0	0	0	17450	768	27	1	729	1	WNT10A	2	219755048	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08		219755048	23444325	3	23709											
UGT1A7	54577	broad.mit.edu	37	chr2	234590879	234590879	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgccgatgctcgctggaCggcaccattgcgaagtgcat	7	11	12	11	4	0	0	0	0	0	0	1	3	0	1	2	2	4	4	2	2	1	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr2:234590879C>T	uc002vut.2	+	1	296	c.296C>T	c.(295-297)ACG>ATG	p.T99M	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Missense_Mutation_p.T99M	NM_019077	NP_061950	Q9HAW7	UD17_HUMAN	UDP glycosyltransferase 1 family, polypeptide A7	99					drug metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	drug binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GCTCGCTGGACGGCACCATTG	0.418													6	105					0	0	0	0	T	234590879	T	T	234590879	3	4	132	1	0	0	0	0	1	0	0	0	17018	536	19	1	298	1	UGT1A7	2	234590879	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08	14835831	234590879	8608494	4	23710											
RBM5	10181	broad.mit.edu	37	chr3	50145726	50145726	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggattggaatctgatgcatCatctgcatcaggtagtaaac	13	11	10	7	0	4	1	2	1	2	0	4	3	4	3	0	3	3	4	0	3	4	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr3:50145726C>T	uc003cyg.2	+	14	1329	c.1181C>T	c.(1180-1182)TCA>TTA	p.S394L	RBM5_uc011bdj.1_Missense_Mutation_p.S338L|RBM5_uc011bdk.1_Missense_Mutation_p.S222L	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	394	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCTGATGCATCATCTGCATCA	0.373													9	49					0	0	0	0	T	50145726	T	T	50145726	3	4	132	1	0	0	0	0	1	0	0	0	13208	838	29	2	1231	2	RBM5	3	50145726	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08		50145726	147876704	5	23711											
ALPK1	80216	broad.mit.edu	37	chr4	113353310	113353310	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttccctgcacaaatgggcaCggctctcatagactgtgcat	9	10	10	12	1	1	1	1	0	1	1	3	1	2	1	1	2	2	5	1	2	2	2			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr4:113353310C>T	uc003iap.3	+	11	2886	c.2607C>T	c.(2605-2607)CAC>CAT	p.H869H	ALPK1_uc003ian.3_Silent_p.H869H|ALPK1_uc011cfx.1_Silent_p.H791H|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Silent_p.H697H	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	869							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		CAAATGGGCACGGCTCTCATA	0.597													13	22					0	0	0	0	T	113353310	T	T	113353310	2	4	132	1	0	0	0	0	0	0	0	1	544	535	19	1		1	ALPK1	4	113353310	Silent	SNP	C	TCGA-CR-6488-01A-12D-2078-08		113353310	77800966	6	23712											
CCRN4L	25819	broad.mit.edu	37	chr4	139966007	139966007	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaccctggtcaccttgtctAgatgtagaacacaacaatgg	14	9	8	10	0	2	2	1	0	1	2	2	2	2	2	2	2	3	1	2	2	6	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr4:139966007A>C	uc003ihl.2	+	3	868	c.675A>C	c.(673-675)CTA>CTC	p.L225L		NM_012118	NP_036250	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like	225					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_hematologic(180;0.162)					CACCTTGTCTAGATGTAGAAC	0.463													26	51					0	0	0	0	C	139966007	C	C	139966007	2	2	132	1	0	0	0	0	0	0	0	1	2966	407	15	5		5	CCRN4L	4	139966007	Silent	SNP	A	TCGA-CR-6488-01A-12D-2078-08	26612697	139966007	51188269	7	23713											
C5orf49	134121	broad.mit.edu	37	chr5	7832094	7832094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcaatgggctgattgatgcGcttcccatagacagaagacg	11	9	11	10	2	1	5	1	2	0	3	2	5	2	5	1	1	1	2	1	1	3	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr5:7832094G>A	uc003jea.3	-	3	443	c.313C>T	c.(313-315)CGC>TGC	p.R105C		NM_001089584	NP_001083053	A4QMS7	CE049_HUMAN	hypothetical protein LOC134121	105											0						TGATTGATGCGCTTCCCATAG	0.542													9	156					0	0	0	0	A	7832094	A	A	7832094	3	1	132	1	0	0	0	0	1	0	0	0	2317	1087	38	1	134	1	C5orf49	5	7832094	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08		7832094	173083166	8	23714											
EDIL3	10085	broad.mit.edu	37	chr5	83402601	83402601	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtagaggaagctgtgatttGctggtttgatataattccac	11	14	11	5	0	0	3	0	2	0	1	1	4	1	4	1	2	2	4	1	2	4	6			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr5:83402601G>T	uc003kio.1	-	6	936	c.517C>A	c.(517-519)CAA>AAA	p.Q173K	EDIL3_uc003kip.1_Missense_Mutation_p.Q163K	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	173	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GCTGTGATTTGCTGGTTTGAT	0.393													17	105					6.94344e-10	8.45838e-10	1	0	T	83402601	T	T	83402601	3	4	132	1	0	0	0	0	1	0	0	0	4937	1328	46	4	949	4	EDIL3	5	83402601	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08	75570507	83402601	97512659	9	23715											
PCDHGB2	56103	broad.mit.edu	37	chr5	140741082	140741082	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacttcctacatggttcaCgtggcagagaacaatcctcc	11	9	8	13	1	1	2	1	0	0	2	4	3	4	2	3	2	2	2	3	2	3	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr5:140741082C>T	uc003ljs.1	+	1	1380	c.1380C>T	c.(1378-1380)CAC>CAT	p.H460H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Silent_p.H460H|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	460	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACATGGTTCACGTGGCAGAGA	0.557													26	67					0	0	0	0	T	140741082	T	T	140741082	2	4	132	1	0	0	0	0	0	0	0	1	11617	535	19	1		1	PCDHGB2	5	140741082	Silent	SNP	C	TCGA-CR-6488-01A-12D-2078-08	57338481	140741082	40174178	10	23716											
KIAA0141	9812	broad.mit.edu	37	chr5	141316762	141316762	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctgtccattttctccttaGgactcacagagcaggtacca	9	12	8	12	0	3	1	1	0	2	1	5	2	4	2	3	2	2	2	3	2	2	4			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr5:141316762G>T	uc003lls.2	+	11	1272	c.1150_splice	c.e11-1	p.D384_splice	KIAA0141_uc003llt.2_Splice_Site_p.D384_splice|KIAA0141_uc003llu.1_Splice_Site	NM_001142603	NP_001136075	Q14154	DELE_HUMAN	hypothetical protein LOC9812 precursor						apoptosis|regulation of caspase activity	mitochondrion	protein binding			skin(1)	1		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTCTCCTTAGGACTCACAGA	0.498													14	86					1.3612e-06	1.60001e-06	1	0	T	141316762	T	T	141316762	5	4	132	1	0	0	0	0	0	0	1	0	8195	1014	35	4	1191	4	KIAA0141	5	141316762	Splice_Site	SNP	G	TCGA-CR-6488-01A-12D-2078-08	575680	141316762	39598498	11	23717											
FOXP4	116113	broad.mit.edu	37	chr6	41566645	41566645	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cggaagacagggacctggagGaggagctgccgggagaagaa	13	2	19	7	2	0	3	0	0	0	3	0	9	0	8	2	6	2	1	2	6	3	0			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr6:41566645G>A	uc003oql.2	+	17	2472	c.2014G>A	c.(2014-2016)GAG>AAG	p.E672K	FOXP4_uc003oqm.2_Missense_Mutation_p.E670K|FOXP4_uc003oqn.2_Missense_Mutation_p.E659K	NM_001012426	NP_001012426	Q8IVH2	FOXP4_HUMAN	forkhead box P4 isoform 1	672					embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					GGACCTGGAGGAGGAGCTGCC	0.687													5	14					0	0	0	0	A	41566645	A	A	41566645	3	1	132	1	0	0	0	0	1	0	0	0	6063	1175	41	2	2076	2	FOXP4	6	41566645	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08		41566645	129548422	12	23718											
CD109	135228	broad.mit.edu	37	chr6	74440235	74440235	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caaagcaagaagtgaagtttCgcattgttacactcttctca	13	12	7	9	1	2	2	1	1	2	1	4	2	2	2	0	0	2	4	0	0	5	4	rs137899447	by1000genomes	TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr6:74440235C>T	uc003php.2	+	4	870	c.445C>T	c.(445-447)CGC>TGC	p.R149C	CD109_uc010kaz.2_Missense_Mutation_p.R149C|CD109_uc003phq.2_Missense_Mutation_p.R149C|CD109_uc010kba.2_Intron	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	149						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						AGTGAAGTTTCGCATTGTTAC	0.373													3	35					0	0	0	0	T	74440235	T	T	74440235	3	4	132	1	0	0	0	0	1	0	0	0	2978	884	31	1	459	1	CD109	6	74440235	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08	32873590	74440235	96674832	13	23719											
TIAM2	26230	broad.mit.edu	37	chr6	155458480	155458480	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gattggcagcgatcccctccGgcagaacatttatgagaatt	11	10	10	10	2	0	2	0	1	0	2	2	5	2	2	3	2	2	2	3	2	3	4			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr6:155458480G>A	uc003qqb.2	+	7	2637	c.1364G>A	c.(1363-1365)CGG>CAG	p.R455Q	TIAM2_uc003qqe.2_Missense_Mutation_p.R455Q|TIAM2_uc010kjj.2_5'UTR	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	455					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GATCCCCTCCGGCAGAACATT	0.512													5	91					0	0	0	0	A	155458480	A	A	155458480	3	1	132	1	0	0	0	0	1	0	0	0	15957	1116	39	1	1370	1	TIAM2	6	155458480	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08	81018245	155458480	15656587	14	23720											
DDX56	54606	broad.mit.edu	37	chr7	44612540	44612540	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cattggccactcggacatccCgagcacagtaggtagccagc	10	6	11	14	2	0	0	0	0	0	0	2	2	1	1	3	3	3	3	3	3	2	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr7:44612540C>T	uc003tlg.2	-	3	975	c.332G>A	c.(331-333)CGG>CAG	p.R111Q	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Missense_Mutation_p.R47Q|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Missense_Mutation_p.R111Q|DDX56_uc010kyh.1_Intron	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	111	Helicase ATP-binding.				rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1						TCGGACATCCCGAGCACAGTA	0.527													38	82					0	0	0	0	T	44612540	T	T	44612540	3	4	132	1	0	0	0	0	1	0	0	0	4391	652	23	1	1359	1	DDX56	7	44612540	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08		44612540	114526123	15	23721											
POM121L12	285877	broad.mit.edu	37	chr7	53103492	53103492	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccagcacgccccagaccaCgccatctccccagggtcgcc	8	3	8	22	3	1	1	0	0	1	1	3	1	1	1	8	1	1	1	8	1	0	0			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr7:53103492C>T	uc003tpz.2	+	1	144	c.128C>T	c.(127-129)ACG>ATG	p.T43M		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	43											0						CCCCAGACCACGCCATCTCCC	0.682													4	39					0	0	0	0	T	53103492	T	T	53103492	3	4	132	1	0	0	0	0	1	0	0	0	12296	536	19	1	130	1	POM121L12	7	53103492	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08	8490952	53103492	106035171	16	23722											
IQUB	154865	broad.mit.edu	37	chr7	123101543	123101543	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaggttaatgcagttacgAcaccggtatatgcggcgtga	11	10	13	7	4	0	2	0	2	0	0	0	3	0	2	1	3	3	4	1	3	5	4			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr7:123101543A>T	uc003vkn.2	-	11	2452	c.1875T>A	c.(1873-1875)TGT>TGA	p.C625*	IQUB_uc011kny.1_5'UTR|IQUB_uc003vko.2_Nonsense_Mutation_p.C625*|IQUB_uc010lkt.2_RNA	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	625										ovary(3)|large_intestine(1)	4						TGCAGTTACGACACCGGTATA	0.368													7	40					0	0	0	0	T	123101543	T	T	123101543	4	4	132	1	0	0	0	0	0	1	0	0	7859	273	10	5	512	5	IQUB	7	123101543	Nonsense_Mutation	SNP	A	TCGA-CR-6488-01A-12D-2078-08	69998051	123101543	36037120	17	23723											
HIF1AN	55662	broad.mit.edu	37	chr10	102296171	102296171	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgttgttttcatttaggagCctgtggtgctgaccgacaca	7	14	11	9	1	1	1	1	1	0	0	1	3	1	2	2	2	2	3	2	2	1	5			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr10:102296171C>A	uc001krj.3	+	2	256	c.181C>A	c.(181-183)CCT>ACT	p.P61T		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	61	Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		CATTTAGGAGCCTGTGGTGCT	0.458													22	104					1.50039e-11	1.8616e-11	1	0	A	102296171	A	A	102296171	3	1	132	1	0	0	0	0	1	0	0	0	7143	739	26	4	187	4	HIF1AN	10	102296171	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08		102296171	33238576	18	23724											
LBX1	10660	broad.mit.edu	37	chr10	102987175	102987175	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctggggggaggaccggagagCcgggcctcgacttggccctg	5	5	19	12	3	0	1	0	0	0	1	1	5	0	3	4	7	1	0	4	7	0	1			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr10:102987175C>T	uc001ksx.2	-	2	843	c.698G>A	c.(697-699)GGC>GAC	p.G233D	uc010qpy.1_5'Flank	NM_006562	NP_006553	P52954	LBX1_HUMAN	ladybird homeobox 1	233					muscle organ development		sequence-specific DNA binding				0		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)		GACCGGAGAGCCGGGCCTCGA	0.756													6	21					0	0	0	0	T	102987175	T	T	102987175	3	4	132	1	0	0	0	0	1	0	0	0	8693	739	26	4	151	4	LBX1	10	102987175	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08	691004	102987175	32547572	19	23725											
CYB5R2	51700	broad.mit.edu	37	chr11	7689764	7689764	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtttttttaggctcactCgtctggtctggtctgattcc	4	18	10	9	1	4	1	1	1	3	0	6	1	5	1	1	3	0	2	1	3	1	5			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr11:7689764C>A	uc001mfm.2	-	6	655	c.417G>T	c.(415-417)ACG>ACT	p.T139T	CYB5R2_uc001mfn.2_RNA|CYB5R2_uc009yfk.2_Silent_p.T139T|CYB5R2_uc009yfl.1_3'UTR	NM_016229	NP_057313	Q6BCY4	NB5R2_HUMAN	cytochrome b5 reductase b5R.2	139					sterol biosynthetic process	membrane|soluble fraction	cytochrome-b5 reductase activity				0				Epithelial(150;5.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TAGGCTCACTCGTCTGGTCTG	0.507													27	104					9.65021e-13	1.21993e-12	1	0	A	7689764	A	A	7689764	2	1	132	1	0	0	0	0	0	0	0	1	4144	871	31	3		3	CYB5R2	11	7689764	Silent	SNP	C	TCGA-CR-6488-01A-12D-2078-08		7689764	127316752	20	23726											
RASGRP2	10235	broad.mit.edu	37	chr11	64508502	64508502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagctccttgatctgctcagCcaactccgggttcaagtcaa	9	10	8	14	1	4	1	3	1	1	0	6	1	6	1	3	1	4	3	3	1	3	2			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr11:64508502C>T	uc009ypu.2	-	5	516	c.289G>A	c.(289-291)GCT>ACT	p.A97T	RASGRP2_uc001oat.2_5'Flank|RASGRP2_uc001oau.2_5'UTR|RASGRP2_uc009ypv.2_Missense_Mutation_p.A97T|RASGRP2_uc009ypw.2_Missense_Mutation_p.A97T	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	97	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						ATCTGCTCAGCCAACTCCGGG	0.597											OREG0004006	type=REGULATORY REGION|Gene=RASGRP2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	9	35					0	0	0	0	T	64508502	T	T	64508502	3	4	132	1	0	0	0	0	1	0	0	0	13140	739	26	4	1588	4	RASGRP2	11	64508502	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08	56818738	64508502	70498014	21	23727											
KLRC2	3822	broad.mit.edu	37	chr12	10584759	10584759	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggatgatgactgctgttaCgaaacacaccaatccatgag	14	9	9	9	1	0	3	0	3	0	0	1	5	1	4	2	1	3	2	2	1	3	1			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr12:10584759C>A	uc001qyk.2	-	5	537	c.530G>T	c.(529-531)CGT>CTT	p.R177L	KLRC3_uc001qyh.2_Intron|KLRC2_uc010she.1_Missense_Mutation_p.R177L	NM_002260	NP_002251	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C,	177	Extracellular (Potential).|C-type lectin.				cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						ACTGCTGTTACGAAACACACC	0.294													11	26					2.48551e-13	3.20248e-13	1	0	A	10584759	A	A	10584759	3	1	132	1	0	0	0	0	1	0	0	0	8455	536	19	3	173	3	KLRC2	12	10584759	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08		10584759	123267136	22	23728											
HIST4H4	121504	broad.mit.edu	37	chr12	14923918	14923918	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgggcgagacggcgaatcGccggctttgtaatgccttgg	6	9	16	10	6	0	1	0	0	0	1	2	3	0	1	2	4	1	2	2	4	2	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr12:14923918G>A	uc001rcf.3	-	1	148	c.101C>T	c.(100-102)GCG>GTG	p.A34V	HIST4H4_uc001rce.2_RNA	NM_175054	NP_778224	P62805	H4_HUMAN	histone cluster 4, H4	34					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						ACGGCGAATCGCCGGCTTTGT	0.607											OREG0021698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	52					0	0	0	0	A	14923918	A	A	14923918	3	1	132	1	0	0	0	0	1	0	0	0	7224	1087	38	1	214	1	HIST4H4	12	14923918	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08	4339159	14923918	118927977	23	23729											
OR4M1	441670	broad.mit.edu	37	chr14	20249043	20249043	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacacaggttgtccggattGcctgtgccaacaccttccca	8	10	8	15	1	1	0	1	0	0	0	3	1	3	1	5	2	3	1	5	2	1	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr14:20249043G>T	uc010tku.1	+	1	562	c.562G>T	c.(562-564)GCC>TCC	p.A188S		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTCCGGATTGCCTGTGCCAA	0.458													21	268					1.64293e-13	2.15836e-13	1	0	T	20249043	T	T	20249043	3	4	132	1	0	0	0	0	1	0	0	0	11129	1319	46	4	564	4	OR4M1	14	20249043	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08		20249043	87100497	24	23730											
OCA2	4948	broad.mit.edu	37	chr15	28230313	28230313	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgatcatggcccacacccGtccccgggagagccggtatg	8	6	13	14	3	1	2	1	1	0	1	2	4	2	2	5	3	1	1	5	3	1	1			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr15:28230313G>A	uc001zbh.3	-	13	1371	c.1261C>T	c.(1261-1263)CGG>TGG	p.R421W	OCA2_uc010ayv.2_Missense_Mutation_p.R397W	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	421	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GCCCACACCCGTCCCCGGGAG	0.572									Oculocutaneous_Albinism				4	11					0	0	0	0	A	28230313	A	A	28230313	3	1	132	1	0	0	0	0	1	0	0	0	10869	1144	40	1	1303	1	OCA2	15	28230313	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08		28230313	74301079	25	23731											
ADAMTS7	11173	broad.mit.edu	37	chr15	79059020	79059021	+	Frame_Shift_Ins	INS	-	A	A																															gggctcctcagagggcccgtINSaggacagatcctcgtggaaa																										TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr15:79059020_79059021insA	uc002bej.3	-	19	3443_3444	c.3232_3233insT	c.(3232-3234)TACfs	p.Y1078fs	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1078					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						AGAGGGCCCGTAGGACAGATCC	0.624													---	---	---								A	79059021	A	A	79059020	7	5	132	1	0	1	1	0	0	0	0	0	271	1638	57	0	1851	0	ADAMTS7	15	79059020	Frame_Shift_Ins	INS	-	TCGA-CR-6488-01A-12D-2078-08	50828707	79059020	23472372	26	23732											
SEZ6L2	26470	broad.mit.edu	37	chr16	29891363	29891363	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatgtgccaggaagggggcGaagcagcgatcctcctcaaa	11	5	13	12	2	1	0	1	0	0	0	3	3	3	1	4	3	3	1	4	3	3	0	rs112977823		TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr16:29891363G>A	uc002duq.3	-	9	1635	c.1395C>T	c.(1393-1395)TTC>TTT	p.F465F	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Silent_p.F395F|SEZ6L2_uc002dur.3_Silent_p.F395F|SEZ6L2_uc002dus.3_Silent_p.F351F|SEZ6L2_uc010vec.1_Silent_p.F465F|SEZ6L2_uc010ved.1_Silent_p.F421F	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	465	Sushi 2.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GGAAGGGGGCGAAGCAGCGAT	0.547													10	29					0	0	0	0	A	29891363	A	A	29891363	2	1	132	1	0	0	0	0	0	0	0	1	14209	1049	37	1		1	SEZ6L2	16	29891363	Silent	SNP	G	TCGA-CR-6488-01A-12D-2078-08		29891363	60463390	27	23733											
DDX19A	55308	broad.mit.edu	37	chr16	70404240	70404240	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcggtgattgagcgcttcCgagagggcaaagagaaggtt	10	8	16	7	3	0	4	0	2	0	2	1	6	1	4	1	3	2	3	1	3	2	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr16:70404240C>T	uc002eyv.2	+	10	1206	c.1135C>T	c.(1135-1137)CGA>TGA	p.R379*	DDX19B_uc010vly.1_Nonsense_Mutation_p.R380*|DDX19A_uc002eys.2_Nonsense_Mutation_p.R380*|DDX19A_uc010cfq.1_Nonsense_Mutation_p.R134*|DDX19A_uc010cfr.2_Nonsense_Mutation_p.R229*|DDX19A_uc010cfs.2_Nonsense_Mutation_p.R202*|DDX19A_uc010vlz.1_Nonsense_Mutation_p.R348*|DDX19A_uc010vma.1_Nonsense_Mutation_p.R289*	NM_018332	NP_060802	Q9NUU7	DD19A_HUMAN	DDX19-like protein	379	Helicase C-terminal.				mRNA transport|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding				0		Ovarian(137;0.221)				TGAGCGCTTCCGAGAGGGCAA	0.622													3	29					0	0	0	0	T	70404240	T	T	70404240	4	4	132	1	0	0	0	0	0	1	0	0	4363	644	23	1	1173	1	DDX19A	16	70404240	Nonsense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08	40512877	70404240	19950513	28	23734											
GGNBP2	79893	broad.mit.edu	37	chr17	34935802	34935802	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcagaagagcagacatggCagatgcttttctatcttggt	10	11	13	7	0	2	4	0	0	2	4	2	4	2	4	0	3	2	4	0	3	2	4			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr17:34935802C>T	uc002hnb.2	+	8	1222	c.973C>T	c.(973-975)CAG>TAG	p.Q325*	GGNBP2_uc002hna.2_Nonsense_Mutation_p.Q325*|GGNBP2_uc002hnc.1_Nonsense_Mutation_p.Q154*	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	325					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GCAGACATGGCAGATGCTTTT	0.433													7	120					0	0	0	0	T	34935802	T	T	34935802	4	4	132	1	0	0	0	0	0	1	0	0	6396	711	25	4	999	4	GGNBP2	17	34935802	Nonsense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08		34935802	46259408	29	23735											
CWC25	54883	broad.mit.edu	37	chr17	36963178	36963178	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catcccatgccctctcttttGctctgctgtcagaggaccct	5	13	7	16	0	3	1	1	0	2	1	5	2	4	2	3	1	3	2	3	1	0	2			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr17:36963178G>C	uc002hqu.2	-	7	895	c.742C>G	c.(742-744)CAA>GAA	p.Q248E	CWC25_uc010wdv.1_Missense_Mutation_p.Q185E|CWC25_uc010wdw.1_RNA|CWC25_uc010wdx.1_RNA	NM_017748	NP_060218	Q9NXE8	CWC25_HUMAN	coiled-coil domain containing 49	248											0						CCTCTCTTTTGCTCTGCTGTC	0.507													13	57					0	0	0	0	C	36963178	C	C	36963178	3	2	132	1	0	0	0	0	1	0	0	0	4086	1328	46	4	551	4	CWC25	17	36963178	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08	2027376	36963178	44232032	30	23736											
GRN	2896	broad.mit.edu	37	chr17	42430078	42430078	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcctgctggcttccgctGcgcagccaggggtaccaagt	5	9	13	14	2	0	0	0	0	0	0	2	0	2	0	4	3	4	5	4	3	2	2			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr17:42430078G>T	uc002igp.1	+	13	1913	c.1694G>T	c.(1693-1695)TGC>TTC	p.C565F	GRN_uc002igr.1_3'UTR	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	565					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GGCTTCCGCTGCGCAGCCAGG	0.667													10	62					7.48243e-07	8.95219e-07	1	0	T	42430078	T	T	42430078	3	4	132	1	0	0	0	0	1	0	0	0	6843	1319	46	4	1740	4	GRN	17	42430078	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08	5466900	42430078	38765132	31	23737											
ABCA8	10351	broad.mit.edu	37	chr17	66883568	66883568	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgaagaccaagaagtacaggGaaacatccaccagcgcctgc	15	3	10	13	2	0	2	0	0	0	2	1	4	1	3	4	1	4	1	4	1	5	1			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr17:66883568G>A	uc002jhp.2	-	23	3283	c.3104C>T	c.(3103-3105)TCC>TTC	p.S1035F	ABCA8_uc002jhq.2_Missense_Mutation_p.S1075F|ABCA8_uc010wqq.1_Missense_Mutation_p.S1075F|ABCA8_uc010wqr.1_Missense_Mutation_p.S1014F	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1035	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					GAAGTACAGGGAAACATCCAC	0.418													11	104					0	0	0	0	A	66883568	A	A	66883568	3	1	132	1	0	0	0	0	1	0	0	0	38	1174	41	2	1705	2	ABCA8	17	66883568	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08	24453490	66883568	14311642	32	23738											
LPIN2	9663	broad.mit.edu	37	chr18	2923796	2923796	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatggaatggtagagcttTgctataccctggtgggtcca	8	13	13	7	0	0	2	0	1	0	1	1	3	1	3	2	4	3	3	2	4	4	5			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr18:2923796T>A	uc002klo.2	-	16	2390	c.2151A>T	c.(2149-2151)GCA>GCT	p.A717A		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	717	C-LIP.				fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GGTAGAGCTTTGCTATACCCT	0.478													21	81					0	0	0	0	A	2923796	A	A	2923796	2	1	132	1	0	0	0	0	0	0	0	1	8969	1799	63	5		5	LPIN2	18	2923796	Silent	SNP	T	TCGA-CR-6488-01A-12D-2078-08		2923796	75153452	33	23739											
RFX2	5990	broad.mit.edu	37	chr19	6004277	6004277	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccagccttccaagctctTggcaaagttacggatggcct	10	9	9	13	1	1	0	0	0	1	0	2	1	2	1	4	3	4	3	4	3	4	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr19:6004277T>A	uc002meb.2	-	13	1704	c.1435A>T	c.(1435-1437)AAG>TAG	p.K479*	RFX2_uc002mec.2_Nonsense_Mutation_p.K454*	NM_000635	NP_000626	P48378	RFX2_HUMAN	regulatory factor X2 isoform a	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|ovary(1)|skin(1)	6						TCCAAGCTCTTGGCAAAGTTA	0.547													29	101					0	0	0	0	A	6004277	A	A	6004277	4	1	132	1	0	0	0	0	0	1	0	0	13328	1821	63	5	760	5	RFX2	19	6004277	Nonsense_Mutation	SNP	T	TCGA-CR-6488-01A-12D-2078-08		6004277	53124706	34	23740											
CILP2	148113	broad.mit.edu	37	chr19	19655208	19655208	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccgagacctcacctcggcGgcgtctgcccccagtgacct	5	6	10	20	4	2	2	1	1	1	1	3	3	2	2	7	2	1	0	7	2	0	0			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr19:19655208G>A	uc002nmv.3	+	8	1939	c.1854G>A	c.(1852-1854)GCG>GCA	p.A618A	CILP2_uc002nmw.3_Silent_p.A624A	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	618						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						TCACCTCGGCGGCGTCTGCCC	0.697													7	118					0	0	0	0	A	19655208	A	A	19655208	2	1	132	1	0	0	0	0	0	0	0	1	3445	1103	39	1		1	CILP2	19	19655208	Silent	SNP	G	TCGA-CR-6488-01A-12D-2078-08	13650931	19655208	39473775	35	23741											
BPIL3	128859	broad.mit.edu	37	chr20	31626754	31626754	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaaccaccaagaccctggctCgcttcattcctgaagtgagt	11	9	8	13	1	1	3	1	2	0	1	3	3	2	3	4	1	1	2	4	1	3	2	rs150580944		TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr20:31626754C>T	uc010zuc.1	+	9	886	c.886C>T	c.(886-888)CGC>TGC	p.R296C	BPIL3_uc010zud.1_Missense_Mutation_p.R235C	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	296			R -> H (de novo variant found in a patient with mental retardation).			extracellular region	lipid binding			ovary(1)|pancreas(1)	2						GACCCTGGCTCGCTTCATTCC	0.557													37	136					0	0	0	0	T	31626754	T	T	31626754	3	4	132	1	0	0	0	0	1	0	0	0	1498	884	31	1	920	1	BPIL3	20	31626754	Missense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08		31626754	31398766	36	23742											
SOX18	54345	broad.mit.edu	37	chr20	62680604	62680604	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacaccatgaaggcgttcAtgggccgccggatgcgcgac	8	5	13	15	5	1	1	1	1	0	0	1	3	1	2	4	3	1	1	4	3	1	1			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr20:62680604A>C	uc002yhs.2	-	1	376	c.266T>G	c.(265-267)ATG>AGG	p.M89R		NM_018419	NP_060889	P35713	SOX18_HUMAN	SRY-box 18	89	HMG box.				angiogenesis|blood vessel endothelial cell migration|endocardial cell differentiation|endocardium formation|establishment of endothelial barrier|heart looping|lymphangiogenesis|lymphatic endothelial cell differentiation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|positive regulation of transcription from RNA polymerase II promoter|vasculogenesis	nucleus	transcription regulatory region DNA binding				0	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					GAAGGCGTTCATGGGCCGCCG	0.537													16	30					0	0	0	0	C	62680604	C	C	62680604	3	2	132	1	0	0	0	0	1	0	0	0	15012	217	8	5	896	5	SOX18	20	62680604	Missense_Mutation	SNP	A	TCGA-CR-6488-01A-12D-2078-08	31053850	62680604	344916	37	23743											
IL17RA	23765	broad.mit.edu	37	chr22	17578691	17578691	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccctggctgccaggtacCtgcctggatgacagctggat	6	11	12	12	0	0	1	0	1	0	0	1	3	1	3	4	4	4	3	4	4	1	2			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr22:17578691C>T	uc002zly.2	+	3	301	c.168C>T	c.(166-168)ACC>ACT	p.T56T	IL17RA_uc010gqt.2_Silent_p.T56T	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	56	Extracellular (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		TGCCAGGTACCTGCCTGGATG	0.567													9	38					0	0	0	0	T	17578691	T	T	17578691	2	4	132	1	0	0	0	0	0	0	0	1	7678	668	24	4		4	IL17RA	22	17578691	Silent	SNP	C	TCGA-CR-6488-01A-12D-2078-08		17578691	33725875	38	23744											
C22orf9	23313	broad.mit.edu	37	chr22	45601760	45601760	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcttcttggagtcccgccGgtacacctccacctccacct	6	9	7	19	2	1	0	0	0	1	0	4	1	4	1	7	2	2	2	7	2	1	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chr22:45601760G>A	uc003bfx.1	-	3	316	c.250C>T	c.(250-252)CGG>TGG	p.R84W	C22orf9_uc010gzw.1_5'UTR|C22orf9_uc003bfv.1_Missense_Mutation_p.R93W|C22orf9_uc003bfw.1_Missense_Mutation_p.R89W|C22orf9_uc010gzx.2_Missense_Mutation_p.R66W	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	84							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		GAGTCCCGCCGGTACACCTCC	0.617													10	49					0	0	0	0	A	45601760	A	A	45601760	3	1	132	1	0	0	0	0	1	0	0	0	2161	1115	39	1	996	1	C22orf9	22	45601760	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08	28023069	45601760	5702806	39	23745											
PHKA2	5256	broad.mit.edu	37	chrX	18972425	18972425	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcgcggtctgcattcttacGgtaggccatgcccaggcccc	6	9	11	15	3	2	0	0	0	2	0	3	0	2	0	4	4	3	2	4	4	2	3			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chrX:18972425G>A	uc004cyv.3	-	2	614	c.184C>T	c.(184-186)CGT>TGT	p.R62C	PHKA2_uc010nfh.1_RNA|PHKA2_uc010nfi.1_Missense_Mutation_p.R4C	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	62					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					GCATTCTTACGGTAGGCCATG	0.597													19	77					0	0	0	0	A	18972425	A	A	18972425	3	1	132	1	0	0	0	0	1	0	0	0	11899	1116	39	1	3651	1	PHKA2	23	18972425	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08		18972425	136298135	40	23746											
MAGEB18	286514	broad.mit.edu	37	chrX	26157441	26157441	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaaacaagaaagtagtgtcGctggtgcatttcttgcttca	11	14	9	7	1	2	1	1	0	1	1	3	1	2	1	0	1	3	4	0	1	5	5			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chrX:26157441G>A	uc004dbq.1	+	2	526	c.339G>A	c.(337-339)TCG>TCA	p.S113S		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	113	MAGE.						protein binding			central_nervous_system(1)	1						AAGTAGTGTCGCTGGTGCATT	0.413													8	11					0	0	0	0	A	26157441	A	A	26157441	2	1	132	1	0	0	0	0	0	0	0	1	9228	1074	38	1		1	MAGEB18	23	26157441	Silent	SNP	G	TCGA-CR-6488-01A-12D-2078-08	7185016	26157441	129113119	41	23747											
CXorf22	170063	broad.mit.edu	37	chrX	35974175	35974175	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttcttaattttaaaccttgTttcatgggtgaacgttcaga	10	17	8	6	1	3	2	2	1	1	1	3	2	3	2	1	1	2	3	1	1	4	7			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chrX:35974175T>G	uc004ddj.2	+	8	1331	c.1272T>G	c.(1270-1272)TGT>TGG	p.C424W	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	424										large_intestine(1)|lung(1)|ovary(1)	3						TTAAACCTTGTTTCATGGGTG	0.368													10	104					0	0	0	0	G	35974175	G	G	35974175	3	3	132	1	0	0	0	0	1	0	0	0	4119	1731	60	5	1302	5	CXorf22	23	35974175	Missense_Mutation	SNP	T	TCGA-CR-6488-01A-12D-2078-08	9816734	35974175	119296385	42	23748											
HEPH	9843	broad.mit.edu	37	chrX	65413378	65413378	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttccagaagagctccagcCgaattgggggcacttactgg	9	10	12	10	1	0	2	0	0	0	2	2	3	2	2	3	3	3	2	3	3	3	4			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chrX:65413378C>T	uc011moz.1	+	8	1336	c.1276C>T	c.(1276-1278)CGA>TGA	p.R426*	HEPH_uc004dwn.2_Nonsense_Mutation_p.R426*|HEPH_uc004dwo.2_Nonsense_Mutation_p.R156*|HEPH_uc010nkr.2_Nonsense_Mutation_p.R426*|HEPH_uc011mpa.1_Nonsense_Mutation_p.R426*	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	423	Extracellular (Potential).|Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						GAGCTCCAGCCGAATTGGGGG	0.393													9	17					0	0	0	0	T	65413378	T	T	65413378	4	4	132	1	0	0	0	0	0	1	0	0	7093	644	23	1	1459	1	HEPH	23	65413378	Nonsense_Mutation	SNP	C	TCGA-CR-6488-01A-12D-2078-08	29439203	65413378	89857182	43	23749											
ANKRD58	347454	broad.mit.edu	37	chrX	118893450	118893450	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccgcgagcgcagtgggcGcgacggctgtggagacaagc	7	3	20	11	6	0	1	0	0	0	1	0	4	0	1	1	4	2	2	1	4	1	0			TCGA-CR-6488-01A-12D-2078-08	TCGA-CR-6488-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8bfa9606-b24d-4803-b551-2e86fb02ae5e	89b37386-4cde-4b98-9870-d1357d03d251	g.chrX:118893450G>A	uc010nql.2	+	1	875	c.820G>A	c.(820-822)GCG>ACG	p.A274T		NM_001105576	NP_001099046	A6NJG2	ANR58_HUMAN	ankyrin repeat domain 58	274											0						CGCAGTGGGCGCGACGGCTGT	0.667													4	21					0	0	0	0	A	118893450	A	A	118893450	3	1	132	1	0	0	0	0	1	0	0	0	684	1087	38	1	822	1	ANKRD58	23	118893450	Missense_Mutation	SNP	G	TCGA-CR-6488-01A-12D-2078-08	53480072	118893450	36377110	44	23750											
GPR153	387509	broad.mit.edu	37	chr1	6314150	6314150	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagggccgacaggatgaaGgacaccatccagatacccat	13	4	12	12	1	0	2	0	1	0	1	1	5	1	4	4	4	1	1	4	4	2	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:6314150G>A	uc001amp.1	-	3	674	c.414C>T	c.(412-414)TCC>TCT	p.S138S		NM_207370	NP_997253	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	138	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)		ACAGGATGAAGGACACCATCC	0.622													28	56					0	0	0	0	A	6314150	A	A	6314150	2	1	133	1	0	0	0	0	0	0	0	1	6697	987	35	4		4	GPR153	1	6314150	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08		6314150	242936471	1	23751											
ZBTB48	3104	broad.mit.edu	37	chr1	6646822	6646822	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgcgggtgcacatggtgtCtcacacaggggagatgccct	7	8	15	11	1	1	1	1	0	1	1	2	2	1	1	1	4	3	2	1	4	0	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:6646822C>G	uc009vmc.1	+	5	1235	c.1112C>G	c.(1111-1113)TCT>TGT	p.S371C	ZBTB48_uc001anx.2_Missense_Mutation_p.S371C|ZBTB48_uc009vmd.1_Missense_Mutation_p.S371C|ZBTB48_uc001any.1_Missense_Mutation_p.S9C	NM_005341	NP_005332	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	371	C2H2-type 3.					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		CACATGGTGTCTCACACAGGG	0.632													5	16					0	0	0	0	G	6646822	G	G	6646822	3	3	133	1	0	0	0	0	1	0	0	0	17616	913	32	2	1126	2	ZBTB48	1	6646822	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	332672	6646822	242603799	2	23752											
MFN2	9927	broad.mit.edu	37	chr1	12062113	12062113	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaagcagattgcagaggcGgttcgactcatcatggactc	10	8	12	11	2	2	2	2	0	0	2	4	4	2	3	1	3	2	3	1	3	1	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:12062113G>A	uc001atn.3	+	11	1566	c.1113G>A	c.(1111-1113)GCG>GCA	p.A371A	MFN2_uc009vni.2_Silent_p.A371A	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	371	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TTGCAGAGGCGGTTCGACTCA	0.587													39	72					0	0	0	0	A	12062113	A	A	12062113	2	1	133	1	0	0	0	0	0	0	0	1	9577	1103	39	1		1	MFN2	1	12062113	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	5415291	12062113	237188508	3	23753											
CLCNKA	1187	broad.mit.edu	37	chr1	16355704	16355704	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactccagcccaccctggccCgaggagctcgacccccagca	9	3	9	20	2	0	0	0	0	0	0	2	3	1	1	6	2	4	2	6	2	1	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:16355704C>T	uc001axu.2	+	12	1217	c.1137C>T	c.(1135-1137)CCC>CCT	p.P379P	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Silent_p.P379P|CLCNKA_uc010obw.1_Silent_p.P336P|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010obx.1_Silent_p.P26P|CLCNKA_uc010oby.1_Nonsense_Mutation_p.R109*	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	379					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CACCCTGGCCCGAGGAGCTCG	0.627													7	69					0	0	0	0	T	16355704	T	T	16355704	2	4	133	1	0	0	0	0	0	0	0	1	3484	639	23	1		1	CLCNKA	1	16355704	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	4293591	16355704	232894917	4	23754											
UBR4	23352	broad.mit.edu	37	chr1	19447699	19447699	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttaccatctttctccttttcTttttcttctttcttgctctt	2	26	1	12	0	7	0	0	0	7	0	8	0	7	0	2	0	2	1	2	0	1	10			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:19447699T>A	uc001bbi.2	-	68	10129	c.10125A>T	c.(10123-10125)AAA>AAT	p.K3375N	UBR4_uc001bbk.1_Missense_Mutation_p.K1022N	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3375					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCTCCTTTTCTTTTTCTTCTT	0.453													32	92					0	0	0	0	A	19447699	A	A	19447699	3	1	133	1	0	0	0	0	1	0	0	0	16972	1606	56	5	5582	5	UBR4	1	19447699	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	3091995	19447699	229802922	5	23755											
PQLC2	54896	broad.mit.edu	37	chr1	19644172	19644172	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcccctcctccacagccAtggtctggaagaaactgggc	8	6	13	14	0	1	1	0	0	1	1	3	2	3	2	5	5	2	0	5	5	2	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:19644172A>G	uc001bby.2	+	3	353	c.1A>G	c.(1-3)ATG>GTG	p.M1V	PQLC2_uc001bbz.2_Intron|PQLC2_uc001bca.2_Missense_Mutation_p.M1V|PQLC2_uc001bcb.2_Intron|PQLC2_uc001bcc.2_5'UTR	NM_017765	NP_060235	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2 isoform 1	1	Extracellular (Potential).					integral to membrane					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCACAGCCATGGTCTGGAA	0.647													41	99					0	0	0	0	G	19644172	G	G	19644172	3	3	133	1	0	0	0	0	1	0	0	0	12479	217	8	5	3	5	PQLC2	1	19644172	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	196473	19644172	229606449	6	23756											
PINK1	65018	broad.mit.edu	37	chr1	20971032	20971032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctcaccccaacatcatcCgggttctccgcgccttcacc	6	8	5	22	3	4	0	3	0	1	0	6	0	5	0	8	1	1	1	8	1	1	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:20971032C>T	uc001bdm.2	+	4	920	c.826C>T	c.(826-828)CGG>TGG	p.R276W		NM_032409	NP_115785	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1 precursor	276	Protein kinase.|Cytoplasmic (Potential).		R -> Q.		cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			ovary(2)|central_nervous_system(1)	3		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CAACATCATCCGGGTTCTCCG	0.592													8	126					0	0	0	0	T	20971032	T	T	20971032	3	4	133	1	0	0	0	0	1	0	0	0	11987	643	23	1	840	1	PINK1	1	20971032	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	1326860	20971032	228279589	7	23757											
MACF1	23499	broad.mit.edu	37	chr1	39920720	39920720	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cattcagcgggatcaggagcCaatcccgcagaacattgacc	12	6	10	13	2	2	2	2	1	0	1	3	4	3	4	3	2	3	1	3	2	2	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:39920720C>A	uc010oiu.1	+	54	16486	c.16355C>A	c.(16354-16356)CCA>CAA	p.P5452Q	MACF1_uc010ois.1_Missense_Mutation_p.P4950Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	6908					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GATCAGGAGCCAATCCCGCAG	0.527													24	35					7.92952e-12	9.15293e-12	1	0	A	39920720	A	A	39920720	3	1	133	1	0	0	0	0	1	0	0	0	9195	594	21	4	21338	4	MACF1	1	39920720	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	18949688	39920720	209329901	8	23758											
KLF17	128209	broad.mit.edu	37	chr1	44595384	44595384	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaagggtagccaggcccttCggtgggaatctaaggatgcc	9	7	14	11	1	1	0	0	0	1	0	2	2	1	2	4	5	2	1	4	5	4	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:44595384C>T	uc001clp.2	+	2	499	c.441C>T	c.(439-441)TTC>TTT	p.F147F	KLF17_uc009vxf.1_Silent_p.F110F	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	147					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CCAGGCCCTTCGGTGGGAATC	0.562													5	50					0	0	0	0	T	44595384	T	T	44595384	2	4	133	1	0	0	0	0	0	0	0	1	8384	883	31	1		1	KLF17	1	44595384	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	4674664	44595384	204655237	9	23759											
NFIA	4774	broad.mit.edu	37	chr1	61920976	61920976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttttccttttgtcttccagtCctggtacctgggataaaagt	7	17	8	9	0	1	0	0	0	1	0	4	1	4	1	4	2	1	1	4	2	3	7			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:61920976C>T	uc001czw.2	+	11	1998	c.1514C>T	c.(1513-1515)TCC>TTC	p.S505F	NFIA_uc001czy.2_Missense_Mutation_p.S497F|NFIA_uc010oos.1_Missense_Mutation_p.S550F|NFIA_uc001czv.2_Silent_p.I474I|NFIA_uc001czx.2_Missense_Mutation_p.S153F|NFIA_uc009wae.2_RNA	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	505					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						GTCTTCCAGTCCTGGTACCTG	0.448													4	81					0	0	0	0	T	61920976	T	T	61920976	3	4	133	1	0	0	0	0	1	0	0	0	10424	869	30	2	1702	2	NFIA	1	61920976	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	17325592	61920976	187329645	10	23760											
C1orf173	127254	broad.mit.edu	37	chr1	75072531	75072531	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctttctcagtgctcttttCtttcctagatttcggcaaag	6	18	6	11	1	3	1	1	0	3	1	7	1	5	1	2	1	1	2	2	1	2	6			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:75072531C>A	uc001dgg.2	-	10	1462	c.1243G>T	c.(1243-1245)GAA>TAA	p.E415*	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Nonsense_Mutation_p.E209*	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	415	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTGCTCTTTTCTTTCCTAGAT	0.403													6	132					0.000157383	0.000169103	1	0	A	75072531	A	A	75072531	4	1	133	1	0	0	0	0	0	1	0	0	2023	922	32	2	3369	2	C1orf173	1	75072531	Nonsense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	13151555	75072531	174178090	11	23761											
CRABP2	1382	broad.mit.edu	37	chr1	156670775	156670775	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgtagaaagtgtctcccTcctgtttgatctccactgct	7	15	8	11	0	2	3	0	2	2	1	5	3	3	3	3	0	1	3	3	0	2	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:156670775T>A	uc001fpr.2	-	2	277	c.140A>T	c.(139-141)GAG>GTG	p.E47V		NM_001878	NP_001869	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	47					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity			upper_aerodigestive_tract(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)	AGTGTCTCCCTCCTGTTTGAT	0.537													28	37					0	0	0	0	A	156670775	A	A	156670775	3	1	133	1	0	0	0	0	1	0	0	0	3859	1551	54	5	288	5	CRABP2	1	156670775	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	81598244	156670775	92579846	12	23762											
COPA	1314	broad.mit.edu	37	chr1	160312934	160312934	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccactacctttgacccgcgcGctcttggtctcgaatttggt	5	13	9	14	4	2	1	0	1	2	0	3	2	2	1	3	2	1	1	3	2	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:160312934G>A	uc009wti.2	-	1	421	c.27C>T	c.(25-27)AGC>AGT	p.S9S	COPA_uc001fvv.3_Silent_p.S9S|COPA_uc009wtj.1_5'UTR|NCSTN_uc009wtk.1_5'Flank|NCSTN_uc001fvx.2_5'Flank|NCSTN_uc001fvy.2_5'Flank|NCSTN_uc010pjf.1_5'Flank	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	9	WD 1.				COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGACCCGCGCGCTCTTGGTCT	0.567													12	249					0	0	0	0	A	160312934	A	A	160312934	2	1	133	1	0	0	0	0	0	0	0	1	3742	1078	38	1		1	COPA	1	160312934	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	3642159	160312934	88937687	13	23763											
MYOC	4653	broad.mit.edu	37	chr1	171621793	171621793	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctctggaaagctctgctgtGctgagaggtgcctggatggg	6	10	16	9	0	2	1	0	1	2	1	2	4	2	3	2	4	4	3	2	4	1	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:171621793G>A	uc001ghu.2	-						MYOC_uc010pmk.1_5'UTR	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor						anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GCTCTGCTGTGCTGAGAGGTG	0.577													10	14					0	0	0	0	A	171621793	A	A	171621793	1	1	133	0	1	0	0	0	0	0	0	0	10139	1334	46	4		4	MYOC	1	171621793	5'Flank	SNP	G	TCGA-CR-6491-01A-11D-1870-08	11308859	171621793	77628828	14	23764											
RC3H1	149041	broad.mit.edu	37	chr1	173961928	173961928	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagcaatgctgagttcaCagggaggagctcaatgtctg	10	9	13	9	0	3	1	2	1	1	0	3	3	3	3	0	2	4	5	0	2	2	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:173961928C>A	uc001gju.3	-	1	283	c.196G>T	c.(196-198)GTG>TTG	p.V66L	RC3H1_uc010pms.1_Missense_Mutation_p.V66L|RC3H1_uc001gjv.2_Missense_Mutation_p.V66L|RC3H1_uc010pmt.1_Missense_Mutation_p.V66L	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	66					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GCTGAGTTCACAGGGAGGAGC	0.393													26	31					7.01153e-11	8.00186e-11	1	0	A	173961928	A	A	173961928	3	1	133	1	0	0	0	0	1	0	0	0	13231	478	17	4	3281	4	RC3H1	1	173961928	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	2340135	173961928	75288693	15	23765											
CEP350	9857	broad.mit.edu	37	chr1	180010837	180010837	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaggtggttcaatcacaacGggaagtaactgaagtcctgc	12	8	12	9	1	2	1	2	1	0	0	3	2	3	2	1	3	3	3	1	3	5	2	rs138458512		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:180010837G>A	uc001gnt.2	+	19	4645	c.4262G>A	c.(4261-4263)CGG>CAG	p.R1421Q	CEP350_uc009wxl.2_Missense_Mutation_p.R1420Q	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1421						centrosome|nucleus|spindle				ovary(4)	4						CAATCACAACGGGAAGTAACT	0.438													8	19					0	0	0	0	A	180010837	A	A	180010837	3	1	133	1	0	0	0	0	1	0	0	0	3269	1116	39	1	4332	1	CEP350	1	180010837	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	6048909	180010837	69239784	16	23766											
CACNA1S	779	broad.mit.edu	37	chr1	201022675	201022675	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcatgacacggaacaggCggaagaaggcgctggagatg	12	4	16	9	3	1	3	1	1	0	2	1	6	1	5	1	5	1	1	1	5	3	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr1:201022675C>T	uc001gvv.2	-	30	3934	c.3707G>A	c.(3706-3708)CGC>CAC	p.R1236H		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1236	IV.|Helical; Name=S4 of repeat IV; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ACGGAACAGGCGGAAGAAGGC	0.622													4	73					0	0	0	0	T	201022675	T	T	201022675	3	4	133	1	0	0	0	0	1	0	0	0	2559	768	27	1	1974	1	CACNA1S	1	201022675	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	21011838	201022675	48227946	17	23767											
OTOF	9381	broad.mit.edu	37	chr2	26700047	26700047	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgggccgcacctcgtccGccaggaagcgcagcttctgc	5	7	12	17	4	1	0	0	0	1	0	3	1	2	1	5	2	3	3	5	2	1	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:26700047G>A	uc002rhk.2	-	21	2643	c.2516C>T	c.(2515-2517)GCG>GTG	p.A839V	OTOF_uc002rhh.2_Missense_Mutation_p.A92V|OTOF_uc002rhi.2_Missense_Mutation_p.A149V|OTOF_uc002rhj.2_Missense_Mutation_p.A92V	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	839	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCTCGTCCGCCAGGAAGCG	0.682													3	18					0	0	0	0	A	26700047	A	A	26700047	3	1	133	1	0	0	0	0	1	0	0	0	11357	1087	38	1	3766	1	OTOF	2	26700047	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08		26700047	216499326	18	23768											
QPCT	25797	broad.mit.edu	37	chr2	37586939	37586939	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggagccactgattcagccGtgccatgtgcaatgatgttg	9	11	12	9	1	1	2	1	2	0	0	1	3	1	3	3	1	4	2	3	1	2	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:37586939G>A	uc002rqg.2	+	3	606	c.484G>A	c.(484-486)GTG>ATG	p.V162M	QPCT_uc002rqh.2_Missense_Mutation_p.V113M	NM_012413	NP_036545	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase precursor	162					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)	1		Ovarian(717;0.051)|all_hematologic(82;0.21)				TGATTCAGCCGTGCCATGTGC	0.443													39	96					0	0	0	0	A	37586939	A	A	37586939	3	1	133	1	0	0	0	0	1	0	0	0	12939	1145	40	1	494	1	QPCT	2	37586939	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	10886892	37586939	205612434	19	23769											
BCL11A	53335	broad.mit.edu	37	chr2	60688292	60688292	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccggccaccgagtcttcgtcGcaagtgtccctgtggccctc	4	9	11	17	4	1	0	0	0	1	0	5	1	2	0	5	2	0	1	5	2	1	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:60688292G>C	uc002sae.1	-	4	1983	c.1755C>G	c.(1753-1755)TGC>TGG	p.C585W	BCL11A_uc002sab.2_Missense_Mutation_p.C585W|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.C254W|BCL11A_uc010ypj.1_Missense_Mutation_p.C551W|BCL11A_uc002sad.1_Missense_Mutation_p.C433W|BCL11A_uc002saf.1_Missense_Mutation_p.C551W	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	585					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			AGTCTTCGTCGCAAGTGTCCC	0.682			T	IGH@	B-CLL								12	30					0	0	0	0	C	60688292	C	C	60688292	3	2	133	1	0	0	0	0	1	0	0	0	1365	1079	38	3	862	3	BCL11A	2	60688292	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	23101353	60688292	182511081	20	23770											
MTHFD2	10797	broad.mit.edu	37	chr2	74441326	74441326	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgctgaggcttgaagagcGagaagtgctgaagtctaaag	12	8	16	5	1	1	5	0	3	1	2	1	6	1	5	0	2	3	3	0	2	5	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:74441326G>A	uc002skk.2	+	8	1089	c.1010G>A	c.(1009-1011)CGA>CAA	p.R337Q	SLC4A5_uc002skl.2_Intron|MTHFD2_uc002skj.2_Missense_Mutation_p.R235Q|MTHFD2_uc010yro.1_Missense_Mutation_p.R235Q|MTHFD2_uc010ffb.2_Missense_Mutation_p.R254Q|MTHFD2_uc010yrp.1_Missense_Mutation_p.R173Q	NM_006636	NP_006627	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase 2	337					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding				0					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CTTGAAGAGCGAGAAGTGCTG	0.468													35	64					0	0	0	0	A	74441326	A	A	74441326	3	1	133	1	0	0	0	0	1	0	0	0	9982	1058	37	1	1040	1	MTHFD2	2	74441326	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	13753034	74441326	168758047	21	23771											
CHN1	1123	broad.mit.edu	37	chr2	175779816	175779816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgtaggtccctggctgcCgctggctctcccggatgagg	5	9	15	12	2	1	1	0	1	1	0	3	2	2	2	3	5	1	4	3	5	2	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:175779816C>T	uc002uji.2	-	5	760	c.230G>A	c.(229-231)CGG>CAG	p.R77Q	CHN1_uc010zeq.1_Missense_Mutation_p.R77Q|CHN1_uc002ujj.2_5'UTR	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	77	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			CCCTGGCTGCCGCTGGCTCTC	0.463			T	TAF15	extraskeletal myxoid chondrosarcoma								3	16					0	0	0	0	T	175779816	T	T	175779816	3	4	133	1	0	0	0	0	1	0	0	0	3377	652	23	1	1185	1	CHN1	2	175779816	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	101338490	175779816	67419557	22	23772											
CERKL	375298	broad.mit.edu	37	chr2	182403829	182403829	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atagacttacctaatatggaCctctgatgcaacttccatta	13	13	5	10	0	1	2	0	1	1	1	2	3	2	3	3	1	3	1	3	1	6	6			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:182403829C>T	uc002unx.2	-	13	1707	c.1606G>A	c.(1606-1608)GTC>ATC	p.V536I	CERKL_uc002uny.2_Missense_Mutation_p.V510I|CERKL_uc010zfm.1_Missense_Mutation_p.V492I|CERKL_uc002unz.2_Missense_Mutation_p.V258I|CERKL_uc002uoa.2_Missense_Mutation_p.V441I|CERKL_uc002uob.2_Missense_Mutation_p.V258I|CERKL_uc002uoc.2_Missense_Mutation_p.V397I|CERKL_uc010frk.2_RNA|CERKL_uc002unw.2_Missense_Mutation_p.V106I	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	536					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CTAATATGGACCTCTGATGCA	0.318													27	45					0	0	0	0	T	182403829	T	T	182403829	3	4	133	1	0	0	0	0	1	0	0	0	3283	507	18	4	78	4	CERKL	2	182403829	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	6624013	182403829	60795544	23	23773											
GULP1	51454	broad.mit.edu	37	chr2	189434779	189434779	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagacttagaaacagaaaatAtggaacttaaaaataaagta	24	8	6	3	0	0	3	0	0	0	3	0	4	0	4	0	1	2	1	0	1	13	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:189434779A>G	uc010fru.2	+	9	1002	c.541A>G	c.(541-543)ATG>GTG	p.M181V	GULP1_uc002uqd.2_Missense_Mutation_p.M181V|GULP1_uc010zfw.1_Missense_Mutation_p.M78V|GULP1_uc002uqf.2_Missense_Mutation_p.M181V|GULP1_uc002uqg.2_Missense_Mutation_p.M181V|GULP1_uc002uqh.1_Missense_Mutation_p.M1V	NM_016315	NP_057399	Q9UBP9	GULP1_HUMAN	GULP, engulfment adaptor PTB domain containing	181	Potential.				apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)			AACAGAAAATATGGAACTTAA	0.289													14	24					0	0	0	0	G	189434779	G	G	189434779	3	3	133	1	0	0	0	0	1	0	0	0	6940	449	16	5	567	5	GULP1	2	189434779	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	7030950	189434779	53764594	24	23774											
SATB2	23314	broad.mit.edu	37	chr2	200173524	200173524	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggaccacgtgttgcatgcGttcgctgtggtgatgccttg	4	13	14	10	3	0	1	0	1	0	0	1	2	0	2	2	2	3	4	2	2	0	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:200173524G>A	uc002uuy.1	-	10	2516	c.1699C>T	c.(1699-1701)CGC>TGC	p.R567C	SATB2_uc010fsq.1_Missense_Mutation_p.R449C|SATB2_uc002uuz.1_Missense_Mutation_p.R567C|SATB2_uc002uva.1_Missense_Mutation_p.R567C	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	567						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGTTGCATGCGTTCGCTGTGG	0.597													20	75					0	0	0	0	A	200173524	A	A	200173524	3	1	133	1	0	0	0	0	1	0	0	0	13919	1145	40	1	510	1	SATB2	2	200173524	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	10738745	200173524	43025849	25	23775											
FN1	2335	broad.mit.edu	37	chr2	216284069	216284069	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acttctcccatgaatctccaAtttgataaaacgtcccagtc	12	12	4	13	1	2	2	0	2	2	0	6	2	3	2	3	0	1	0	3	0	4	3	rs150405747		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:216284069A>T	uc002vfa.2	-	12	1981	c.1715T>A	c.(1714-1716)ATT>AAT	p.I572N	FN1_uc002vfb.2_Missense_Mutation_p.I572N|FN1_uc002vfc.2_Missense_Mutation_p.I572N|FN1_uc002vfd.2_Missense_Mutation_p.I572N|FN1_uc002vfe.2_Missense_Mutation_p.I572N|FN1_uc002vff.2_Missense_Mutation_p.I572N|FN1_uc002vfg.2_Missense_Mutation_p.I572N|FN1_uc002vfh.2_Missense_Mutation_p.I572N|FN1_uc002vfi.2_Missense_Mutation_p.I572N|FN1_uc002vfj.2_Missense_Mutation_p.I572N|FN1_uc002vfl.2_Missense_Mutation_p.I572N	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	572	Fibronectin type-I 9.|Collagen-binding.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAATCTCCAATTTGATAAAA	0.418													14	34					0	0	0	0	T	216284069	T	T	216284069	3	4	133	1	0	0	0	0	1	0	0	0	5994	101	4	5	5891	5	FN1	2	216284069	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	16110545	216284069	26915304	26	23776											
STK36	27148	broad.mit.edu	37	chr2	219540848	219540848	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggtggaggagcgaccataCgaccacacagcggacctctg	10	5	13	13	3	1	0	0	0	1	0	1	5	1	3	3	4	3	0	3	4	1	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:219540848C>T	uc002viu.2	+	6	797	c.531C>T	c.(529-531)TAC>TAT	p.Y177Y	STK36_uc002viv.2_Silent_p.Y177Y	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	177	Protein kinase.				cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		AGCGACCATACGACCACACAG	0.532													7	132					0	0	0	0	T	219540848	T	T	219540848	2	4	133	1	0	0	0	0	0	0	0	1	15368	547	19	1		1	STK36	2	219540848	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	3256779	219540848	23658525	27	23777											
UGT1A5	54579	broad.mit.edu	37	chr2	234621836	234621836	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcctcaccctggaggtgaatAtgtacatcaaagaagagaac	15	8	9	9	0	2	3	2	1	0	2	3	5	3	4	2	2	2	1	2	2	6	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:234621836A>G	uc002vuw.2	+	1	199	c.199A>G	c.(199-201)ATG>GTG	p.M67V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Missense_Mutation_p.M67V	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	67					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		GGAGGTGAATATGTACATCAA	0.547													23	49					0	0	0	0	G	234621836	G	G	234621836	3	3	133	1	0	0	0	0	1	0	0	0	17016	449	16	5	201	5	UGT1A5	2	234621836	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	15080988	234621836	8577537	28	23778											
COL6A3	1293	broad.mit.edu	37	chr2	238303780	238303780	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctcgaacaagttggaaatgTtcctctccaatggtccaaga	12	11	8	10	1	2	1	0	0	2	1	6	3	4	2	3	2	1	2	3	2	5	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr2:238303780T>A	uc002vwl.2	-	3	444	c.159A>T	c.(157-159)GAA>GAT	p.E53D	COL6A3_uc002vwo.2_Intron|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Intron|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Missense_Mutation_p.E53D	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	53	VWFA 1.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GTTGGAAATGTTCCTCTCCAA	0.368													15	23					0	0	0	0	A	238303780	A	A	238303780	3	1	133	1	0	0	0	0	1	0	0	0	3716	1722	60	5	9589	5	COL6A3	2	238303780	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	3681944	238303780	4895593	29	23779											
NUP210	23225	broad.mit.edu	37	chr3	13377046	13377046	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccaccaccctcagcccggTccggccttttacccggccga	6	6	9	20	4	1	0	1	0	0	0	2	2	2	0	8	3	2	0	8	3	1	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:13377046T>C	uc003bxv.1	-	28	3834	c.3751A>G	c.(3751-3753)ACC>GCC	p.T1251A		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1251	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CTCAGCCCGGTCCGGCCTTTT	0.592													8	37					0	0	0	0	C	13377046	C	C	13377046	3	2	133	1	0	0	0	0	1	0	0	0	10814	1667	58	5	1964	5	NUP210	3	13377046	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08		13377046	184645384	30	23780											
FBLN2	2199	broad.mit.edu	37	chr3	13679190	13679190	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcttccgcattggccccgCgccagccttcacgggggaca	6	8	11	16	4	2	0	1	0	1	0	3	1	3	1	5	3	1	1	5	3	1	4	rs112412824		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:13679190C>T	uc011avb.1	+	17	3451	c.3326C>T	c.(3325-3327)GCG>GTG	p.A1109V	FBLN2_uc011auz.1_Missense_Mutation_p.A1135V|FBLN2_uc011ava.1_Missense_Mutation_p.A1156V|FBLN2_uc011avc.1_Missense_Mutation_p.A1156V	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	1109	Domain III.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			ATTGGCCCCGCGCCAGCCTTC	0.622													9	0					0	0	0	0	T	13679190	T	T	13679190	3	4	133	1	0	0	0	0	1	0	0	0	5731	768	27	1	2223	1	FBLN2	3	13679190	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	302144	13679190	184343240	31	23781											
ANKRD28	23243	broad.mit.edu	37	chr3	15731669	15731669	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccactactatttctgacaTcaagatctaacaaagactgt	14	13	4	10	0	3	3	1	1	2	2	4	3	4	3	1	0	2	0	1	0	5	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:15731669T>C	uc003caj.1	-	18	1873	c.1730A>G	c.(1729-1731)GAT>GGT	p.D577G	ANKRD28_uc003cai.1_Missense_Mutation_p.D423G|ANKRD28_uc011avz.1_Missense_Mutation_p.D423G|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.D607G|ANKRD28_uc003cam.2_Missense_Mutation_p.D610G	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	577	ANK 16.					nucleoplasm	protein binding			breast(1)	1						ATTTCTGACATCAAGATCTAA	0.363													2	5					0	0	0	0	C	15731669	C	C	15731669	3	2	133	1	0	0	0	0	1	0	0	0	656	1435	50	5	1475	5	ANKRD28	3	15731669	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	2052479	15731669	182290761	32	23782											
XIRP1	165904	broad.mit.edu	37	chr3	39227515	39227530	+	Frame_Shift_Del	DEL	CCATCCTGAATTGTCA	-	-																															cgggatgagcggtgtagatgCcatcctgaattgtcacccac																										TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:39227515_39227530delCCATCCTGAATTGTCA	uc003cjk.1	-	2	3628_3643	c.3407_3422delTGACAATTCAGGATGG	c.(3406-3423)GTGACAATTCAGGATGGCfs	p.V1136fs	XIRP1_uc003cji.2_Intron|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1136_1141							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGTGTAGATGCCATCCTGAATTGTCACCCACCCCCC	0.606													---	---	---								-	39227530	-	-	39227515	7	5	133	1	0	1	0	1	0	0	0	0	17497	739	26	0	2113	0	XIRP1	3	39227515	Frame_Shift_Del	DEL	CCATCCTGAATTGTCA	TCGA-CR-6491-01A-11D-1870-08	23495846	39227515	158794915	33	23783											
IFRD2	7866	broad.mit.edu	37	chr3	50326350	50326350	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actgcagagggcctccatgtCctcgtaaacaaactcctcct	10	9	7	15	1	0	1	0	0	0	1	5	1	4	1	5	1	3	2	5	1	3	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:50326350C>A	uc011bdp.1	-	9	1225	c.1096G>T	c.(1096-1098)GAC>TAC	p.D366Y	IFRD2_uc003czb.2_Missense_Mutation_p.D468Y	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	366							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCCTCCATGTCCTCGTAAACA	0.587													8	3					0.000157383	0.000169103	1	0	A	50326350	A	A	50326350	3	1	133	1	0	0	0	0	1	0	0	0	7593	855	30	2	440	2	IFRD2	3	50326350	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	11098835	50326350	147696080	34	23784											
FLNB	2317	broad.mit.edu	37	chr3	58104676	58104676	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actgtgggtgttgctgcaccGctggatctgagcaagataaa	10	10	13	8	1	1	2	0	1	1	1	1	3	1	3	1	2	3	5	1	2	3	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:58104676G>T	uc003djj.2	+	19	2988	c.2823G>T	c.(2821-2823)CCG>CCT	p.P941P	FLNB_uc010hne.2_Silent_p.P941P|FLNB_uc003djk.2_Silent_p.P941P|FLNB_uc010hnf.2_Silent_p.P941P|FLNB_uc003djl.2_Silent_p.P772P|FLNB_uc003djm.2_Silent_p.P772P	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	941	Filamin 8.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TTGCTGCACCGCTGGATCTGA	0.517													6	47					0.00116845	0.00124224	1	0	T	58104676	T	T	58104676	2	4	133	1	0	0	0	0	0	0	0	1	5966	1074	38	3		3	FLNB	3	58104676	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	7778326	58104676	139917754	35	23785											
FLNB	2317	broad.mit.edu	37	chr3	58111419	58111419	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggtgcaagcccaaggacctgGattgaaagaggcctttacca	12	7	12	10	0	0	2	0	1	0	1	0	4	0	4	4	4	3	1	4	4	4	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:58111419G>T	uc003djj.2	+	23	4175	c.4010G>T	c.(4009-4011)GGA>GTA	p.G1337V	FLNB_uc010hne.2_Missense_Mutation_p.G1337V|FLNB_uc003djk.2_Missense_Mutation_p.G1337V|FLNB_uc010hnf.2_Missense_Mutation_p.G1337V|FLNB_uc003djl.2_Missense_Mutation_p.G1168V|FLNB_uc003djm.2_Missense_Mutation_p.G1168V	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1337	Filamin 12.|Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CAAGGACCTGGATTGAAAGAG	0.522													36	34					9.04072e-19	1.06176e-18	1	0	T	58111419	T	T	58111419	3	4	133	1	0	0	0	0	1	0	0	0	5966	1174	41	2	4100	2	FLNB	3	58111419	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	6743	58111419	139911011	36	23786											
KPNA1	3836	broad.mit.edu	37	chr3	122145937	122145937	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtcttcatcttcggtcccGaagtaatgctcaataagatc	10	13	7	11	2	4	1	2	0	2	1	7	2	5	1	1	1	1	2	1	1	4	4	rs143005503		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:122145937G>A	uc003efd.1	-	14	1548	c.1512C>T	c.(1510-1512)TTC>TTT	p.F504F	KPNA1_uc003efb.1_Silent_p.F303F|KPNA1_uc003efc.1_Silent_p.F303F|KPNA1_uc011bjr.1_Silent_p.F303F|KPNA1_uc010hrh.2_Silent_p.F303F|KPNA1_uc003efe.2_Silent_p.F504F	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	504	ARM 10; atypical.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		CTTCGGTCCCGAAGTAATGCT	0.438													3	57					0	0	0	0	A	122145937	A	A	122145937	2	1	133	1	0	0	0	0	0	0	0	1	8468	1049	37	1		1	KPNA1	3	122145937	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	64034518	122145937	75876493	37	23787											
MSL2	55167	broad.mit.edu	37	chr3	135870380	135870380	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttgtacacagtcttggtaGgacttcctggcataaaatga	11	14	9	7	0	1	1	0	1	1	0	2	2	2	2	1	3	1	3	1	3	4	7			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:135870380G>C	uc003eqx.1	-	2	2076	c.1343C>G	c.(1342-1344)CCT>CGT	p.P448R	MSL2_uc011bmb.1_Missense_Mutation_p.P374R	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	448	Lys-rich.				histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						AGTCTTGGTAGGACTTCCTGG	0.423													37	96					0	0	0	0	C	135870380	C	C	135870380	3	2	133	1	0	0	0	0	1	0	0	0	9931	1000	35	4	394	4	MSL2	3	135870380	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	13724443	135870380	62152050	38	23788											
PLSCR1	5359	broad.mit.edu	37	chr3	146251283	146251283	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgctgtcggtggatactgaGgaggatacccaactggcaag	11	8	14	8	1	0	1	0	1	0	0	1	4	0	4	1	5	4	2	1	5	4	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:146251283G>C	uc003evx.3	-	3	456	c.68C>G	c.(67-69)CCT>CGT	p.P23R	PLSCR1_uc003evy.3_Missense_Mutation_p.P16R|PLSCR1_uc011bnn.1_Missense_Mutation_p.L15V|PLSCR1_uc003evz.3_RNA|PLSCR1_uc003ewa.2_Missense_Mutation_p.P23R	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	23	Cytoplasmic.|SH3-binding 1 (Potential).|WW-binding 1 (Potential).				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						TGGATACTGAGGAGGATACCC	0.313													46	68					0	0	0	0	C	146251283	C	C	146251283	3	2	133	1	0	0	0	0	1	0	0	0	12164	1000	35	4	916	4	PLSCR1	3	146251283	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	10380903	146251283	51771147	39	23789											
AGTR1	185	broad.mit.edu	37	chr3	148458873	148458873	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attaaaagaatccaagatgaTtgtcccaaagctggaaggca	17	8	9	7	0	0	3	0	1	0	2	2	4	2	4	2	2	1	2	2	2	6	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:148458873T>C	uc003ewg.2	+	4	497	c.51T>C	c.(49-51)GAT>GAC	p.D17D	AGTR1_uc003ewh.2_Silent_p.D17D|AGTR1_uc003ewi.2_Silent_p.D17D|AGTR1_uc003ewj.2_Silent_p.D17D|AGTR1_uc003ewk.2_Silent_p.D17D	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	17	Extracellular (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	TCCAAGATGATTGTCCCAAAG	0.363													28	32					0	0	0	0	C	148458873	C	C	148458873	2	2	133	1	0	0	0	0	0	0	0	1	401	1490	52	5		5	AGTR1	3	148458873	Silent	SNP	T	TCGA-CR-6491-01A-11D-1870-08	2207590	148458873	49563557	40	23790											
IGSF10	285313	broad.mit.edu	37	chr3	151166715	151166715	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgaagtatttagcacgaTgtagtcattttcttcagtga	13	15	8	5	1	3	2	2	2	1	0	3	3	3	2	0	0	1	3	0	0	5	7			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:151166715T>C	uc011bod.1	-	4	1054	c.1054A>G	c.(1054-1056)ATC>GTC	p.I352V		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	352					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTTAGCACGATGTAGTCATTT	0.398													26	52					0	0	0	0	C	151166715	C	C	151166715	3	2	133	1	0	0	0	0	1	0	0	0	7636	1464	51	5	6877	5	IGSF10	3	151166715	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	2707842	151166715	46855715	41	23791											
NLGN1	22871	broad.mit.edu	37	chr3	173998698	173998698	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgctgtttctgaacatcttgGcctttgcagccctgtactac	6	15	8	12	0	2	1	0	1	2	0	2	1	2	1	2	1	6	4	2	1	3	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr3:173998698G>T	uc003fio.1	+	7	2500	c.2077G>T	c.(2077-2079)GCC>TCC	p.A693S	NLGN1_uc003fip.1_Missense_Mutation_p.A693S	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	710	Helical; (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GAACATCTTGGCCTTTGCAGC	0.463													50	68					2.27781e-18	2.65964e-18	1	0	T	173998698	T	T	173998698	3	4	133	1	0	0	0	0	1	0	0	0	10515	1203	42	4	2095	4	NLGN1	3	173998698	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	22831983	173998698	24023732	42	23792											
HTT	3064	broad.mit.edu	37	chr4	3101073	3101073	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcagtgatgacgcagaGtcagatgtcaggatggtggc	9	9	16	7	1	2	4	2	2	0	2	2	5	2	5	0	3	1	2	0	3	0	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:3101073G>A	uc011bvq.1	+	4	571	c.426G>A	c.(424-426)GAG>GAA	p.E142E		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	140					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		ATGACGCAGAGTCAGATGTCA	0.388													4	59					0	0	0	0	A	3101073	A	A	3101073	2	1	133	1	0	0	0	0	0	0	0	1	7496	1020	36	4		4	HTT	4	3101073	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08		3101073	188053203	43	23793											
TLR6	10333	broad.mit.edu	37	chr4	38830188	38830188	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattgtcaatgctttcaatgTcgttttagaataagtaaaat	14	17	6	4	1	2	1	2	0	0	1	3	1	2	1	0	0	1	3	0	0	8	7			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:38830188T>C	uc003gtm.2	-	1	973	c.907A>G	c.(907-909)ACA>GCA	p.T303A	TLR6_uc010ifg.1_Missense_Mutation_p.T303A	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	303	Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						GCTTTCAATGTCGTTTTAGAA	0.318													10	11					0	0	0	0	C	38830188	C	C	38830188	3	2	133	1	0	0	0	0	1	0	0	0	16021	1667	58	5	1487	5	TLR6	4	38830188	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	35729115	38830188	152324088	44	23794											
KIT	3815	broad.mit.edu	37	chr4	55594178	55594178	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatgtttccaattttagcGagtgcccatttgacagaacg	10	13	9	9	2	0	2	0	1	0	1	1	3	1	2	2	0	4	2	2	0	3	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:55594178G>T	uc010igr.2	+	13	1968	c.1881G>T	c.(1879-1881)CCG>CCT	p.P627P	KIT_uc010igs.2_Silent_p.P623P|KIT_uc010igt.1_Silent_p.P76P	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	627	Protein kinase.|Cytoplasmic (Potential).				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.P627L(1)		soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CAATTTTAGCGAGTGCCCATT	0.433		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				36	48					3.21399e-22	3.79665e-22	1	0	T	55594178	T	T	55594178	2	4	133	1	0	0	0	0	0	0	0	1	8368	1072	37	3		3	KIT	4	55594178	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	16763990	55594178	135560098	45	23795											
EPHA5	2044	broad.mit.edu	37	chr4	66467472	66467472	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggaggttcatcggtcacaGaatggttgacacaggagcct	10	9	14	8	1	2	2	2	1	0	1	3	4	2	4	1	5	1	2	1	5	1	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:66467472G>C	uc003hcy.2	-	3	990	c.797C>G	c.(796-798)TCT>TGT	p.S266C	EPHA5_uc003hcx.2_Missense_Mutation_p.S197C|EPHA5_uc003hcz.2_Missense_Mutation_p.S266C|EPHA5_uc011cah.1_Missense_Mutation_p.S266C|EPHA5_uc011cai.1_Missense_Mutation_p.S266C|EPHA5_uc003hda.2_Missense_Mutation_p.S266C	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	266	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						ATCGGTCACAGAATGGTTGAC	0.527										TSP Lung(17;0.13)			23	32					0	0	0	0	C	66467472	C	C	66467472	3	2	133	1	0	0	0	0	1	0	0	0	5194	942	33	2	2380	2	EPHA5	4	66467472	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	10873294	66467472	124686804	46	23796											
TMPRSS11F	389208	broad.mit.edu	37	chr4	68934384	68934384	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatgtgttactgatgaggCtggctccacactgatggcct	7	11	12	11	0	0	3	0	3	0	0	1	3	1	3	3	3	1	3	3	3	1	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:68934384C>G	uc003hdt.1	-	7	756	c.707G>C	c.(706-708)AGC>ACC	p.S236T	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	236	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						ACTGATGAGGCTGGCTCCACA	0.522													5	71					0	0	0	0	G	68934384	G	G	68934384	3	3	133	1	0	0	0	0	1	0	0	0	16309	797	28	4	625	4	TMPRSS11F	4	68934384	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	2466912	68934384	122219892	47	23797											
SLC4A4	8671	broad.mit.edu	37	chr4	72425949	72425949	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaaaaagaagaagggaaGtctggacagtgacaatgatg	20	5	13	3	0	1	5	0	2	1	3	1	7	1	7	0	2	0	0	0	2	7	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:72425949G>T	uc003hfy.2	+	23	3194	c.3077G>T	c.(3076-3078)AGT>ATT	p.S1026I	SLC4A4_uc010iic.2_Missense_Mutation_p.S1026I|SLC4A4_uc010iib.2_Missense_Mutation_p.S942I|SLC4A4_uc003hfz.2_Missense_Mutation_p.S1026I|SLC4A4_uc003hgc.3_Missense_Mutation_p.S982I|SLC4A4_uc010iid.2_Missense_Mutation_p.S230I	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	1026	Cytoplasmic (Potential).			S->D: Loss of regulation by cAMP of the transporter stoichiometry. Shifts transporter stoichiometry from 3:1 to 2:1.|S->A: Prevents phosphorylation by PKA. Loss of regulation by cAMP of the transporter stoichiometry.		basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			aagaagGGAAGTCTGGACAGT	0.323													16	25					4.7546e-09	5.36553e-09	1	0	T	72425949	T	T	72425949	3	4	133	1	0	0	0	0	1	0	0	0	14720	1029	36	4	3284	4	SLC4A4	4	72425949	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	3491565	72425949	118728327	48	23798											
UNC5C	8633	broad.mit.edu	37	chr4	96141148	96141148	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caactgaccttgtcttgctgCcttgatgttcacaggctgaa	8	13	9	11	0	2	3	1	3	1	0	2	3	2	3	2	1	3	3	2	1	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:96141148C>T	uc003htp.1	-	8	1442	c.1288G>A	c.(1288-1290)GCA>ACA	p.A430T	UNC5C_uc010ilc.1_Missense_Mutation_p.A449T|UNC5C_uc003htq.2_Missense_Mutation_p.A449T	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	430	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TGTCTTGCTGCCTTGATGTTC	0.383													33	79					0	0	0	0	T	96141148	T	T	96141148	3	4	133	1	0	0	0	0	1	0	0	0	17061	739	26	4	1543	4	UNC5C	4	96141148	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	23715199	96141148	95013128	49	23799											
C4orf3	401152	broad.mit.edu	37	chr4	120221571	120221571	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaaccagtaggagtgtttGggaagcccatttgccccaga	10	9	11	11	0	0	1	0	0	0	1	1	3	1	3	5	2	3	2	5	2	3	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr4:120221571G>A	uc003icv.3	-	1	398	c.120C>T	c.(118-120)CCC>CCT	p.P40P		NM_001001701	NP_001001701	Q8WVX3	CD003_HUMAN	hypothetical protein LOC401152	40						integral to membrane					0						AGGAGTGTTTGGGAAGCCCAT	0.517													47	71					0	0	0	0	A	120221571	A	A	120221571	2	1	133	1	0	0	0	0	0	0	0	1	2270	1335	47	4		4	C4orf3	4	120221571	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	24080423	120221571	70932705	50	23800											
SLC6A19	340024	broad.mit.edu	37	chr5	1219624	1219624	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcccccggcctgcaggcctCatctgcctggggacattcct	4	9	11	17	1	2	0	1	0	1	0	4	1	4	1	6	4	2	1	6	4	0	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr5:1219624C>T	uc003jbw.3	+	10	1439	c.1383C>T	c.(1381-1383)CTC>CTT	p.L461L		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	461	Helical; Name=9; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTGCAGGCCTCATCTGCCTGG	0.637													14	19					0	0	0	0	T	1219624	T	T	1219624	2	4	133	1	0	0	0	0	0	0	0	1	14746	813	29	2		2	SLC6A19	5	1219624	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08		1219624	179695636	51	23801											
SFRS12	140890	broad.mit.edu	37	chr5	65458371	65458371	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgcagaccaaaattctgtaCcaagggcccttgcttttaat	11	13	7	10	0	1	1	0	0	1	1	1	1	1	1	3	1	3	3	3	1	5	6			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr5:65458371C>T	uc003juo.2	+	6	1018	c.358C>T	c.(358-360)CCA>TCA	p.P120S	SFRS12_uc003jun.2_Missense_Mutation_p.P236S|SFRS12_uc010iwy.2_Missense_Mutation_p.P120S	NM_139168	NP_631907	Q8WXA9	SREK1_HUMAN	splicing factor, arginine/serine-rich 12 isoform	120	RRM.				mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding				0		Lung NSC(167;9.34e-06)|Prostate(74;0.00187)|Ovarian(174;0.0545)|Breast(144;0.0928)|Colorectal(97;0.234)		Lung(70;0.00449)		AAATTCTGTACCAAGGGCCCT	0.378													9	62					0	0	0	0	T	65458371	T	T	65458371	3	4	133	1	0	0	0	0	1	0	0	0	14232	507	18	4	724	4	SFRS12	5	65458371	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	64238747	65458371	115456889	52	23802											
EFNA5	1946	broad.mit.edu	37	chr5	106723440	106723440	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagactttgagctttagacAggaccttcttccattatctg	11	14	7	9	0	2	3	0	1	2	2	3	4	3	4	2	1	1	1	2	1	3	6			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr5:106723440A>G	uc003kol.2	-	3	733	c.451T>C	c.(451-453)TGT>CGT	p.C151R		NM_001962	NP_001953	P52803	EFNA5_HUMAN	ephrin-A5 precursor	151					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding				0		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		AGCTTTAGACAGGACCTTCTT	0.438													10	144					0	0	0	0	G	106723440	G	G	106723440	3	3	133	1	0	0	0	0	1	0	0	0	4976	188	7	5	247	5	EFNA5	5	106723440	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	41265069	106723440	74191820	53	23803											
DPYSL3	1809	broad.mit.edu	37	chr5	146778660	146778660	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttacagactggtggttcttGgcagagacgatcttcacagc	9	11	11	10	1	3	2	1	0	2	2	3	4	3	2	0	3	2	2	0	3	1	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr5:146778660G>T	uc003lon.1	-	11	1376	c.1266C>A	c.(1264-1266)GCC>GCA	p.A422A	DPYSL3_uc003loo.2_Silent_p.A536A	NM_001387	NP_001378	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	422					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGTTCTTGGCAGAGACGA	0.512													7	90					9.70103e-10	1.1009e-09	1	0	T	146778660	T	T	146778660	2	4	133	1	0	0	0	0	0	0	0	1	4770	1335	47	4		4	DPYSL3	5	146778660	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	40055220	146778660	34136600	54	23804											
GFPT2	9945	broad.mit.edu	37	chr5	179751887	179751887	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactccgatgagcagggggCtgcctctcctgtagggagaa	8	7	16	10	1	1	2	0	1	1	1	3	5	2	3	3	4	2	3	3	4	2	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr5:179751887C>A	uc003mlw.1	-	8	703	c.605G>T	c.(604-606)AGC>ATC	p.S202I		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	202	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	GAGCAGGGGGCTGCCTCTCCT	0.527													36	64					9.80977e-26	1.17253e-25	1	0	A	179751887	A	A	179751887	3	1	133	1	0	0	0	0	1	0	0	0	6383	797	28	4	1491	4	GFPT2	5	179751887	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	32973227	179751887	1163373	55	23805											
TFAP2A	7020	broad.mit.edu	37	chr6	10410525	10410526	+	Frame_Shift_Ins	INS	-	G	G																															ttgacctacagtgcccagctINSggggcaaccgtgccgtcccg																										TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:10410525_10410526insG	uc003myr.2	-	2	340_341	c.88_89insC	c.(88-90)CAGfs	p.Q30fs	TFAP2A_uc003myq.2_Frame_Shift_Ins_p.Q24fs|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Frame_Shift_Ins_p.Q30fs|TFAP2A_uc003myt.2_Frame_Shift_Ins_p.Q26fs|TFAP2A_uc003myu.1_Frame_Shift_Ins_p.Q30fs|TFAP2A_uc003myv.1_Frame_Shift_Ins_p.Q16fs|TFAP2A_uc011dii.1_Frame_Shift_Ins_p.Q26fs|uc003myw.2_5'Flank	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	30	Gln/Pro-rich (transactivation domain).				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGTGCCCAGCTGGGGCAACCGT	0.614													---	---	---								G	10410526	G	G	10410525	7	5	133	1	0	1	1	0	0	0	0	0	15853	1580	55	0	1248	0	TFAP2A	6	10410525	Frame_Shift_Ins	INS	-	TCGA-CR-6491-01A-11D-1870-08		10410525	160704542	56	23806											
HIST1H2AL	8332	broad.mit.edu	37	chr6	27833150	27833150	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcatgtcgggacgcggcaaGcagggaggcaaagctcgcgc	9	4	17	11	5	1	0	1	0	0	0	3	2	1	2	0	4	2	4	0	4	2	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:27833150G>C	uc003njw.2	+	1	44	c.18G>C	c.(16-18)AAG>AAC	p.K6N		NM_003511	NP_003502	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	6					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GACGCGGCAAGCAGGGAGGCA	0.582													10	122					0	0	0	0	C	27833150	C	C	27833150	3	2	133	1	0	0	0	0	1	0	0	0	7177	962	34	4	20	4	HIST1H2AL	6	27833150	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	17422625	27833150	143281917	57	23807											
SYNGAP1	8831	broad.mit.edu	37	chr6	33400552	33400552	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcagctttcgccagatcCtgcctcgcttccgaagtgct	6	10	9	16	3	0	1	0	0	0	1	4	2	2	1	5	0	4	4	5	0	1	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:33400552C>T	uc011dri.1	+	5	673	c.478C>T	c.(478-480)CTG>TTG	p.L160L	SYNGAP1_uc003oeo.1_Silent_p.L145L|SYNGAP1_uc010juy.2_Silent_p.L145L	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	160	PH.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						TCGCCAGATCCTGCCTCGCTT	0.557													20	29					0	0	0	0	T	33400552	T	T	33400552	2	4	133	1	0	0	0	0	0	0	0	1	15513	680	24	4		4	SYNGAP1	6	33400552	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	5567402	33400552	137714515	58	23808											
PI16	221476	broad.mit.edu	37	chr6	36930912	36930912	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtggaaacccaggcccCaacttccttagcaacgaaag	12	7	9	13	1	0	0	0	0	0	0	1	2	1	1	4	2	5	2	4	2	5	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:36930912C>T	uc003ona.2	+	5	1122	c.794C>T	c.(793-795)CCA>CTA	p.P265L	PI16_uc003omz.1_Intron|PI16_uc003onb.2_Intron|PI16_uc011dts.1_Missense_Mutation_p.P36L	NM_153370	NP_699201	Q6UXB8	PI16_HUMAN	protease inhibitor 16 precursor	265	Extracellular (Potential).					extracellular region|integral to membrane	peptidase inhibitor activity				0						ACCCAGGCCCCAACTTCCTTA	0.577													8	89					0	0	0	0	T	36930912	T	T	36930912	3	4	133	1	0	0	0	0	1	0	0	0	11924	594	21	4	812	4	PI16	6	36930912	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	3530360	36930912	134184155	59	23809											
ABCC10	89845	broad.mit.edu	37	chr6	43406408	43406408	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgtccaagggctttggcCtggccacccaggaaccctgg	6	7	14	14	0	0	0	0	0	0	0	1	1	1	1	5	6	1	2	5	6	2	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:43406408C>T	uc003ouy.1	+	8	2217	c.2002C>T	c.(2002-2004)CTG>TTG	p.L668L	ABCC10_uc003ouz.1_Silent_p.L640L|ABCC10_uc010jyo.1_5'UTR	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	668	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGGCTTTGGCCTGGCCACCCA	0.592													32	47					0	0	0	0	T	43406408	T	T	43406408	2	4	133	1	0	0	0	0	0	0	0	1	50	680	24	4		4	ABCC10	6	43406408	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	6475496	43406408	127708659	60	23810											
KCNQ5	56479	broad.mit.edu	37	chr6	73904678	73904678	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggaaagcatttctgacgtCaccacctgccttgttgcctc	8	11	8	14	1	2	1	1	1	1	0	3	2	2	2	4	1	3	2	4	1	1	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:73904678C>T	uc003pgk.2	+	14	2687	c.2340C>T	c.(2338-2340)GTC>GTT	p.V780V	KCNQ5_uc011dyh.1_Silent_p.V799V|KCNQ5_uc011dyi.1_Silent_p.V790V|KCNQ5_uc010kat.2_Silent_p.V771V|KCNQ5_uc011dyj.1_Silent_p.V670V|KCNQ5_uc011dyk.1_Silent_p.V530V	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	780					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TTTCTGACGTCACCACCTGCC	0.507													7	39					0	0	0	0	T	73904678	T	T	73904678	2	4	133	1	0	0	0	0	0	0	0	1	8125	813	29	2		2	KCNQ5	6	73904678	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	30498270	73904678	97210389	61	23811											
MYO6	4646	broad.mit.edu	37	chr6	76602328	76602328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagcaggagcgcagggacCgggagctggccctgaggatt	8	5	19	9	2	0	1	0	1	0	0	0	6	0	6	2	6	3	3	2	6	0	1	rs148245729		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:76602328C>T	uc003pih.1	+	28	3307	c.3028C>T	c.(3028-3030)CGG>TGG	p.R1010W	MYO6_uc003pig.1_Missense_Mutation_p.R1010W|MYO6_uc003pii.1_Missense_Mutation_p.R1010W|MYO6_uc003pij.1_5'Flank	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	1010	Glu-rich.|Potential.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GCGCAGGGACCGGGAGCTGGC	0.647													23	19					0	0	0	0	T	76602328	T	T	76602328	3	4	133	1	0	0	0	0	1	0	0	0	10134	643	23	1	3134	1	MYO6	6	76602328	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	2697650	76602328	94512739	62	23812											
SYNE1	23345	broad.mit.edu	37	chr6	152639352	152639352	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttctgtactgctgcatctAattccattaactttgaatta	11	18	4	8	0	2	1	0	1	2	0	3	1	3	1	1	0	4	3	1	0	5	7			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr6:152639352A>T	uc010kiw.2	-	86	17038	c.16436T>A	c.(16435-16437)TTA>TAA	p.L5479*	SYNE1_uc010kiv.2_Nonsense_Mutation_p.L3*|SYNE1_uc003qos.3_Nonsense_Mutation_p.L3*|SYNE1_uc003qot.3_Nonsense_Mutation_p.L5408*|SYNE1_uc003qou.3_Nonsense_Mutation_p.L5479*|SYNE1_uc010kiz.2_Nonsense_Mutation_p.L1234*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5479	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCTGCATCTAATTCCATTAA	0.403										HNSCC(10;0.0054)			27	19					0	0	0	0	T	152639352	T	T	152639352	4	4	133	1	0	0	0	0	0	1	0	0	15511	372	13	5	10274	5	SYNE1	6	152639352	Nonsense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	76037024	152639352	18475715	63	23813											
GLCCI1	113263	broad.mit.edu	37	chr7	8125840	8125840	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taggtctcgtcagcctatctCggcccctctcttttcatgtc	4	15	7	15	2	5	0	2	0	3	0	9	0	5	0	3	2	1	0	3	2	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:8125840C>T	uc003srk.2	+	8	1875	c.1316C>T	c.(1315-1317)TCG>TTG	p.S439L		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	439											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		CAGCCTATCTCGGCCCCTCTC	0.388													13	221					0	0	0	0	T	8125840	T	T	8125840	3	4	133	1	0	0	0	0	1	0	0	0	6468	893	31	1	1346	1	GLCCI1	7	8125840	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08		8125840	151012823	64	23814											
DNAH11	8701	broad.mit.edu	37	chr7	21627788	21627788	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taatacagagctggatgtgtGtaagcaactgtataatgaac	15	11	10	5	0	0	2	0	1	0	1	0	3	0	3	0	1	5	4	0	1	7	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:21627788G>A	uc003svc.2	+	10	1848	c.1817G>A	c.(1816-1818)TGT>TAT	p.C606Y		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	606	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTGGATGTGTGTAAGCAACTG	0.368									Kartagener_syndrome				5	37					0	0	0	0	A	21627788	A	A	21627788	3	1	133	1	0	0	0	0	1	0	0	0	4621	1377	48	4	1855	4	DNAH11	7	21627788	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	13501948	21627788	137510875	65	23815											
URGCP	55665	broad.mit.edu	37	chr7	43918683	43918683	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtggtattcctggcatcagCattgagggcctgcaacttcc	8	11	11	11	0	1	1	1	1	0	0	3	1	3	1	3	3	3	4	3	3	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:43918683C>A	uc003tiw.2	-	6	436	c.379G>T	c.(379-381)GCT>TCT	p.A127S	URGCP_uc003tiu.2_Missense_Mutation_p.A84S|URGCP_uc003tiv.2_Missense_Mutation_p.A52S|URGCP_uc003tix.2_Missense_Mutation_p.A118S|URGCP_uc003tiy.2_Missense_Mutation_p.A84S|URGCP_uc003tiz.2_Missense_Mutation_p.A84S|URGCP_uc011kbj.1_Missense_Mutation_p.A84S	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	127					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						CTGGCATCAGCATTGAGGGCC	0.547													40	70					4.0492e-12	4.70079e-12	1	0	A	43918683	A	A	43918683	3	1	133	1	0	0	0	0	1	0	0	0	17094	710	25	4	2420	4	URGCP	7	43918683	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	22290895	43918683	115219980	66	23816											
GCK	2645	broad.mit.edu	37	chr7	44187278	44187278	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggggtttgcagagctctcGtccaccaggcggtcatactc	6	9	12	14	3	2	1	1	0	1	1	5	1	3	1	3	4	3	3	3	4	1	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:44187278G>A	uc003tkl.2	-	7	1304	c.834C>T	c.(832-834)GAC>GAT	p.D278D	GCK_uc003tkh.1_5'Flank|GCK_uc003tki.1_5'Flank|GCK_uc003tkj.1_Silent_p.D277D|GCK_uc003tkk.1_Silent_p.D279D	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	278					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						CAGAGCTCTCGTCCACCAGGC	0.687													36	38					0	0	0	0	A	44187278	A	A	44187278	2	1	133	1	0	0	0	0	0	0	0	1	6328	1136	40	1		1	GCK	7	44187278	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	268595	44187278	114951385	67	23817											
ZNF716	441234	broad.mit.edu	37	chr7	57522865	57522865	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaaatgagatggtagccAaacacccaggtaggtgagag	16	5	14	6	0	0	3	0	2	0	3	0	6	0	3	2	3	2	2	2	3	4	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:57522865A>C	uc011kdi.1	+	3	365	c.253A>C	c.(253-255)AAA>CAA	p.K85Q		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						GATGGTAGCCAAACACCCAGG	0.443													7	113					0	0	0	0	C	57522865	C	C	57522865	3	2	133	1	0	0	0	0	1	0	0	0	18186	131	5	5	263	5	ZNF716	7	57522865	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	13335587	57522865	101615798	68	23818											
BAZ1B	9031	broad.mit.edu	37	chr7	72856543	72856543	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctacttcttctgtcttcGtcccctggactgtccaacgg	4	15	7	15	2	4	0	0	0	4	0	8	1	6	1	3	2	2	0	3	2	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:72856543G>A	uc003tyc.2	-	19	4780	c.4435C>T	c.(4435-4437)CGA>TGA	p.R1479*		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	1479					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				TTCTGTCTTCGTCCCCTGGAC	0.597													8	187					0	0	0	0	A	72856543	A	A	72856543	4	1	133	1	0	0	0	0	0	1	0	0	1332	1153	40	1	20	1	BAZ1B	7	72856543	Nonsense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	15333678	72856543	86282120	69	23819											
CYP3A5	1577	broad.mit.edu	37	chr7	99264261	99264261	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgcctttctctgcttcccGcctcaagtttctcaccaata	6	15	4	16	1	3	0	2	0	2	0	6	0	4	0	4	0	2	2	4	0	3	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:99264261G>A	uc003urq.2	-	6	571	c.484C>T	c.(484-486)CGG>TGG	p.R162W	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_Intron|CYP3A5_uc003urr.2_Missense_Mutation_p.R49W|CYP3A5_uc011kiy.1_Missense_Mutation_p.R152W|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	162					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	TCTGCTTCCCGCCTCAAGTTT	0.493													11	191					0	0	0	0	A	99264261	A	A	99264261	3	1	133	1	0	0	0	0	1	0	0	0	4197	1086	38	1	1056	1	CYP3A5	7	99264261	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	26407718	99264261	59874402	70	23820											
TES	26136	broad.mit.edu	37	chr7	115892374	115892374	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttatcttcttcctagctGatattcagcaatgagtatac	10	18	5	8	0	3	2	1	2	2	0	4	2	4	2	1	0	3	3	1	0	6	10			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:115892374G>A	uc003vho.2	+	6	1102	c.921G>A	c.(919-921)CTG>CTA	p.L307L	TES_uc011kmy.1_Silent_p.L65L|TES_uc003vhp.2_Silent_p.L298L|uc003vhq.1_5'Flank	NM_015641	NP_056456	Q9UGI8	TES_HUMAN	testin isoform 1	307	LIM zinc-binding 2.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding				0	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			CTTCCTAGCTGATATTCAGCA	0.348													8	58					0	0	0	0	A	115892374	A	A	115892374	2	1	133	1	0	0	0	0	0	0	0	1	15831	1277	45	2		2	TES	7	115892374	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	16628113	115892374	43246289	71	23821											
PTPRZ1	5803	broad.mit.edu	37	chr7	121616905	121616905	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgaaagtgttagtcgttttGgtaagctacttggggaacta	10	14	12	5	2	0	0	0	0	0	0	2	2	0	1	0	3	3	4	0	3	6	7			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:121616905G>T	uc003vjy.2	+	6	1014	c.619G>T	c.(619-621)GGG>TGG	p.G207W	PTPRZ1_uc003vjz.2_Missense_Mutation_p.G207W	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	207	Extracellular (Potential).|Alpha-carbonic anhydrase.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TAGTCGTTTTGGTAAGCTACT	0.353													7	57					1.12685e-05	1.2304e-05	1	0	T	121616905	T	T	121616905	3	4	133	1	0	0	0	0	1	0	0	0	12879	1362	47	4	641	4	PTPRZ1	7	121616905	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	5724531	121616905	37521758	72	23822											
MLL3	58508	broad.mit.edu	37	chr7	151874275	151874275	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctgtatatgcaatgatatCaaactctcctgaccttaaga	14	13	5	9	0	3	3	1	2	2	1	4	3	3	3	2	0	2	2	2	0	6	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr7:151874275C>G	uc003wla.2	-	38	8482	c.8263G>C	c.(8263-8265)GAT>CAT	p.D2755H	MLL3_uc003wkz.2_Missense_Mutation_p.D1816H|MLL3_uc003wky.2_Missense_Mutation_p.D264H	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2755	Asp-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCAATGATATCAAACTCTCCT	0.358			N		medulloblastoma								9	64					0	0	0	0	G	151874275	G	G	151874275	3	3	133	1	0	0	0	0	1	0	0	0	9675	826	29	2	6560	2	MLL3	7	151874275	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	30257370	151874275	7264388	73	23823											
C8orf58	541565	broad.mit.edu	37	chr8	22460089	22460089	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaggtcaaggtcctgctcAaccggatctgccggagaagc	11	6	12	12	2	3	1	2	0	1	1	4	3	4	2	3	4	4	1	3	4	4	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:22460089A>G	uc003xce.2	+	6	1031	c.919A>G	c.(919-921)AAC>GAC	p.N307D	C8orf58_uc011kzl.1_Missense_Mutation_p.N299D|C8orf58_uc003xcf.2_Intron|KIAA1967_uc003xch.2_5'Flank|KIAA1967_uc003xci.2_5'Flank	NM_001013842	NP_001013864	Q8NAV2	CH058_HUMAN	hypothetical protein LOC541565	307										skin(1)	1		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GGTCCTGCTCAACCGGATCTG	0.662													12	27					0	0	0	0	G	22460089	G	G	22460089	3	3	133	1	0	0	0	0	1	0	0	0	2445	130	5	5	941	5	C8orf58	8	22460089	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08		22460089	123903933	74	23824											
EPHX2	2053	broad.mit.edu	37	chr8	27401308	27401308	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacggcggagaaggacttcGtgctcgttcctcagatgtcc	7	10	12	12	4	2	2	2	0	0	2	6	4	4	3	2	3	1	2	2	3	1	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:27401308G>A	uc003xfu.2	+	17	1573	c.1492G>A	c.(1492-1494)GTG>ATG	p.V498M	EPHX2_uc010luu.2_Missense_Mutation_p.V466M|EPHX2_uc010luv.2_Missense_Mutation_p.V432M|EPHX2_uc003xfv.2_Missense_Mutation_p.V445M|EPHX2_uc010luw.2_Missense_Mutation_p.V432M	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	498	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	GAAGGACTTCGTGCTCGTTCC	0.612													6	54					0	0	0	0	A	27401308	A	A	27401308	3	1	133	1	0	0	0	0	1	0	0	0	5204	1145	40	1	1558	1	EPHX2	8	27401308	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	4941219	27401308	118962714	75	23825											
ELP3	55140	broad.mit.edu	37	chr8	27964292	27964292	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacatcagttttacaggaaaTatatgtgtgtaagtatggtg	13	14	10	4	0	1	0	1	0	0	0	1	1	1	1	0	2	1	3	0	2	6	6			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:27964292T>C	uc003xgo.3	+	4	469	c.321T>C	c.(319-321)AAT>AAC	p.N107N	ELP3_uc003xgn.3_Silent_p.N92N|ELP3_uc011laq.1_Silent_p.N35N|ELP3_uc011lar.1_Silent_p.N15N|ELP3_uc011las.1_Missense_Mutation_p.Y10H|ELP3_uc011lat.1_Missense_Mutation_p.Y10H	NM_018091	NP_060561	Q9H9T3	ELP3_HUMAN	elongation protein 3 homolog	107					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding				0		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		TTACAGGAAATATATGTGTGT	0.333													24	48					0	0	0	0	C	27964292	C	C	27964292	2	2	133	1	0	0	0	0	0	0	0	1	5105	1403	49	5		5	ELP3	8	27964292	Silent	SNP	T	TCGA-CR-6491-01A-11D-1870-08	562984	27964292	118399730	76	23826											
C8orf41	80185	broad.mit.edu	37	chr8	33364791	33364792	+	Frame_Shift_Ins	INS	-	A	A																															tacaggtggttggaaatggcINSatggtataggacctgggctc																										TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:33364791_33364792insA	uc003xjl.3	-	3	1407_1408	c.882_883insT	c.(880-885)CATGCCfs	p.H294fs	C8orf41_uc003xjk.3_Intron|C8orf41_uc010lvv.2_Frame_Shift_Ins_p.H294fs|C8orf41_uc003xjm.3_Frame_Shift_Ins_p.H294fs|C8orf41_uc003xjn.1_Frame_Shift_Ins_p.H294fs	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	294_295							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		TTGGAAATGGCATGGTATAGGA	0.406													---	---	---								A	33364792	A	A	33364791	7	5	133	1	0	1	1	0	0	0	0	0	2439	710	25	0	663	0	C8orf41	8	33364791	Frame_Shift_Ins	INS	-	TCGA-CR-6491-01A-11D-1870-08	5400499	33364791	112999231	77	23827											
PKHD1L1	93035	broad.mit.edu	37	chr8	110476920	110476920	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caatactgtccattctcaagGttggtttggaatgtggatct	9	15	10	7	0	2	0	1	0	2	0	4	2	3	2	1	4	1	2	1	4	4	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:110476920G>T	uc003yne.2	+	49	7963	c.7859G>T	c.(7858-7860)GGT>GTT	p.G2620V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2620	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CATTCTCAAGGTTGGTTTGGA	0.418										HNSCC(38;0.096)			112	133					2.55716e-62	3.07467e-62	1	0	T	110476920	T	T	110476920	3	4	133	1	0	0	0	0	1	0	0	0	12027	1261	44	4	8053	4	PKHD1L1	8	110476920	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	77112129	110476920	35887102	78	23828											
MED30	90390	broad.mit.edu	37	chr8	118552171	118552171	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaaattatggatcaattacGaaatctcatctgggatataa	17	12	6	6	1	3	0	2	0	2	0	4	3	3	2	0	2	1	0	0	2	7	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:118552171G>A	uc003yoj.2	+	4	642	c.491G>A	c.(490-492)CGA>CAA	p.R164Q	MED30_uc011lib.1_Missense_Mutation_p.R129Q	NM_080651	NP_542382	Q96HR3	MED30_HUMAN	TRAP/Mediator complex component TRAP25	164	Potential.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding				0	all_cancers(13;3.41e-25)|Lung NSC(37;3.02e-05)|Ovarian(258;0.00163)		STAD - Stomach adenocarcinoma(47;0.0266)			GATCAATTACGAAATCTCATC	0.318													4	41					0	0	0	0	A	118552171	A	A	118552171	3	1	133	1	0	0	0	0	1	0	0	0	9501	1058	37	1	505	1	MED30	8	118552171	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	8075251	118552171	27811851	79	23829											
KCNQ3	3786	broad.mit.edu	37	chr8	133150233	133150233	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcctcaaagtctccttgaaTttttttttatagagacggaa	11	15	8	7	1	2	2	1	1	1	1	3	4	2	3	2	2	0	0	2	2	5	7			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:133150233T>A	uc003ytj.2	-	12	1824	c.1599A>T	c.(1597-1599)AAA>AAT	p.K533N	KCNQ3_uc010mdt.2_Missense_Mutation_p.K533N	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	533					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TCTCCTTGAATTTTTTTTTAT	0.453													55	107					0	0	0	0	A	133150233	A	A	133150233	3	1	133	1	0	0	0	0	1	0	0	0	8123	1490	52	5	1035	5	KCNQ3	8	133150233	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	14598062	133150233	13213789	80	23830											
COL22A1	169044	broad.mit.edu	37	chr8	139601575	139601575	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagggtcacattggcctgggGgaccgggaggtcctgggagg	7	6	20	8	1	1	0	1	0	0	0	2	3	2	3	3	8	0	0	3	8	1	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr8:139601575G>A	uc003yvd.2	-	65	5249	c.4802C>T	c.(4801-4803)CCC>CTC	p.P1601L	COL22A1_uc011ljo.1_Missense_Mutation_p.P881L	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1601	Pro-rich.|Gly-rich.|Collagen-like 16.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTGGCCTGGGGGACCGGGAGG	0.617										HNSCC(7;0.00092)			8	39					0	0	0	0	A	139601575	A	A	139601575	3	1	133	1	0	0	0	0	1	0	0	0	3696	1232	43	4	82	4	COL22A1	8	139601575	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	6451342	139601575	6762447	81	23831											
IFNA6	3443	broad.mit.edu	37	chr9	21350758	21350758	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaagagagattctcctcatTtgtgccaggagcatcatggt	12	11	10	8	0	3	2	2	0	1	2	4	4	3	3	2	2	2	1	2	2	2	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:21350758T>C	uc011lni.1	-	1	129	c.129A>G	c.(127-129)CAA>CAG	p.Q43Q		NM_021002	NP_066282	P05013	IFNA6_HUMAN	interferon, alpha 6 precursor	43					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TTCTCCTCATTTGTGCCAGGA	0.537													67	30					0	0	0	0	C	21350758	C	C	21350758	2	2	133	1	0	0	0	0	0	0	0	1	7580	1838	64	5		5	IFNA6	9	21350758	Silent	SNP	T	TCGA-CR-6491-01A-11D-1870-08		21350758	119862673	82	23832											
POLR1E	64425	broad.mit.edu	37	chr9	37486777	37486777	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agaacaaagattccaccaacCccaggaagaggaatcaacgg	18	3	9	11	1	1	3	1	0	0	3	2	5	2	5	4	3	3	0	4	3	6	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:37486777C>T	uc003zzz.1	+	1	628	c.340C>T	c.(340-342)CCC>TCC	p.P114S	POLR1E_uc011lqj.1_Missense_Mutation_p.P52S|POLR1E_uc003zzy.1_Missense_Mutation_p.P52S|POLR1E_uc011lqk.1_5'UTR	NM_022490	NP_071935	Q9GZS1	RPA49_HUMAN	RNA polymerase I associated factor 53	114					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		TTCCACCAACCCCAGGAAGAG	0.537													6	47					0	0	0	0	T	37486777	T	T	37486777	3	4	133	1	0	0	0	0	1	0	0	0	12268	623	22	4	160	4	POLR1E	9	37486777	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	16136019	37486777	103726654	83	23833											
CORO2A	7464	broad.mit.edu	37	chr9	100899882	100899882	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcagaacaggaggcgatcTcaaaatcatcaaaagggttc	15	8	9	9	1	4	1	4	0	1	1	6	3	4	2	0	3	1	1	0	3	5	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:100899882T>A	uc004ayl.2	-	3	556	c.290A>T	c.(289-291)GAG>GTG	p.E97V	CORO2A_uc004aym.2_Missense_Mutation_p.E97V	NM_003389	NP_003380	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	97	WD 1.				actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			skin(2)|ovary(1)|pancreas(1)	4		Acute lymphoblastic leukemia(62;0.0559)				GGAGGCGATCTCAAAATCATC	0.542													51	122					0	0	0	0	A	100899882	A	A	100899882	3	1	133	1	0	0	0	0	1	0	0	0	3771	1551	54	5	1327	5	CORO2A	9	100899882	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	63413105	100899882	40313549	84	23834											
OR1N2	138882	broad.mit.edu	37	chr9	125315629	125315629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaccatggtggggaacctgCtcattatcctggccatcagc	8	10	10	13	0	3	0	3	0	0	0	4	1	4	1	4	4	3	1	4	4	2	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:125315629C>T	uc011lyx.1	+	1	181	c.181C>T	c.(181-183)CTC>TTC	p.L61F		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	61	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						GGGGAACCTGCTCATTATCCT	0.522													11	167					0	0	0	0	T	125315629	T	T	125315629	3	4	133	1	0	0	0	0	1	0	0	0	11024	797	28	4	183	4	OR1N2	9	125315629	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	24415747	125315629	15897802	85	23835											
PBX3	5090	broad.mit.edu	37	chr9	128723127	128723127	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcccaccacaccaaattcCggtgcgtactgggggctcgc	7	7	11	16	4	0	0	0	0	0	0	3	0	1	0	4	3	2	2	4	3	2	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr9:128723127C>T	uc004bqb.2	+	6	1124	c.1008C>T	c.(1006-1008)TCC>TCT	p.S336S	PBX3_uc004bqc.2_Silent_p.S155S|PBX3_uc004bqd.2_Silent_p.S155S|PBX3_uc011lzw.1_Silent_p.S261S|PBX3_uc011lzx.1_Silent_p.S247S|PBX3_uc004bqe.2_Silent_p.S244S	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	336					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						CACCAAATTCCGGTGCGTACT	0.587													3	19					0	0	0	0	T	128723127	T	T	128723127	2	4	133	1	0	0	0	0	0	0	0	1	11548	666	23	1		1	PBX3	9	128723127	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	3407498	128723127	12490304	86	23836											
UPF2	26019	broad.mit.edu	37	chr10	11994186	11994186	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcactgatcatgtaatctatAtcaataggaaatggatggtc	14	13	8	6	0	4	1	3	1	1	0	5	3	4	3	0	3	0	1	0	3	6	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:11994186A>G	uc001ila.2	-	14	3387	c.2913T>C	c.(2911-2913)GAT>GAC	p.D971D	UPF2_uc001ilb.2_Silent_p.D971D|UPF2_uc001ilc.2_Silent_p.D971D|UPF2_uc009xiz.1_Silent_p.D971D	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	971	MIF4G 3.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				TGTAATCTATATCAATAGGAA	0.348													38	55					0	0	0	0	G	11994186	G	G	11994186	2	3	133	1	0	0	0	0	0	0	0	1	17072	446	16	5		5	UPF2	10	11994186	Silent	SNP	A	TCGA-CR-6491-01A-11D-1870-08		11994186	123540561	87	23837											
CDC123	8872	broad.mit.edu	37	chr10	12238301	12238301	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtggtacccgttcttccgAggcgttaccatcaagaggtg	7	10	13	11	4	2	1	1	0	1	1	3	2	3	1	3	3	2	3	3	3	3	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:12238301A>T	uc001ill.2	+	1	341	c.57A>T	c.(55-57)CGA>CGT	p.R19R	NUDT5_uc001ilj.2_5'Flank|NUDT5_uc001ilk.2_5'Flank|CDC123_uc009xja.2_Silent_p.R19R|CDC123_uc001ilm.2_Silent_p.R19R	NM_006023	NP_006014	O75794	CD123_HUMAN	cell division cycle 123	19					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm				central_nervous_system(1)	1						CGTTCTTCCGAGGCGTTACCA	0.572													22	48					0	0	0	0	T	12238301	T	T	12238301	2	4	133	1	0	0	0	0	0	0	0	1	3070	291	11	5		5	CDC123	10	12238301	Silent	SNP	A	TCGA-CR-6491-01A-11D-1870-08	244115	12238301	123296446	88	23838											
SPAG6	9576	broad.mit.edu	37	chr10	22699991	22699991	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatagcaaagctcgacgacTttttgtaacaagtggtggcc	11	11	11	8	2	0	1	0	1	0	0	1	3	0	1	1	2	3	3	1	2	4	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:22699991T>A	uc001iri.2	+	10	1488	c.1346T>A	c.(1345-1347)CTT>CAT	p.L449H	SPAG6_uc001irj.2_Intron|SPAG6_uc010qct.1_Missense_Mutation_p.L419H|SPAG6_uc009xkh.2_Missense_Mutation_p.L427H	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	449					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						GCTCGACGACTTTTTGTAACA	0.378													25	32					0	0	0	0	A	22699991	A	A	22699991	3	1	133	1	0	0	0	0	1	0	0	0	15048	1609	56	5	1384	5	SPAG6	10	22699991	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	10461690	22699991	112834756	89	23839											
WAC	51322	broad.mit.edu	37	chr10	28872436	28872436	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagcaaaacttcagatgcagTaagtattataaacatgtcca	18	10	6	7	0	1	1	1	0	0	1	2	1	2	1	1	0	4	4	1	0	8	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:28872436T>G	uc001iuf.2	+	4	466	c.381_splice	c.e4+2	p.A127_splice	WAC_uc001iud.2_Splice_Site_p.A82_splice|WAC_uc001iue.2_Intron|WAC_uc009xlb.2_Splice_Site_p.A82_splice|WAC_uc001iug.2_Splice_Site_p.A127_splice|WAC_uc001iuh.2_Splice_Site_p.A82_splice	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil						cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						TCAGATGCAGTAAGTATTATA	0.313													49	84					0	0	0	0	G	28872436	G	G	28872436	5	3	133	1	0	0	0	0	0	0	1	0	17315	1652	57	5	397	5	WAC	10	28872436	Splice_Site	SNP	T	TCGA-CR-6491-01A-11D-1870-08	6172445	28872436	106662311	90	23840											
IPMK	253430	broad.mit.edu	37	chr10	60027245	60027245	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggggcacgcagccgttgaGgaagcggagtctgccgcccg	7	4	18	12	5	1	1	0	1	1	0	1	4	1	3	3	4	3	3	3	4	1	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:60027245G>C	uc001jkb.2	-	1	450	c.127C>G	c.(127-129)CTC>GTC	p.L43V	CISD1_uc001jkc.3_5'Flank	NM_152230	NP_689416	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	43						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			ovary(1)	1						CAGCCGTTGAGGAAGCGGAGT	0.701													12	17					0	0	0	0	C	60027245	C	C	60027245	3	2	133	1	0	0	0	0	1	0	0	0	7831	1000	35	4	1147	4	IPMK	10	60027245	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	31154809	60027245	75507502	91	23841											
TSPAN14	81619	broad.mit.edu	37	chr10	82269158	82269158	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaccggttccgggagttcttCgagagcaacatcaagtccta	10	9	11	11	3	2	1	1	0	1	1	5	4	4	2	3	2	2	3	3	2	3	4	rs145582053	byFrequency	TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:82269158C>T	uc001kcj.3	+	5	488	c.381C>T	c.(379-381)TTC>TTT	p.F127F	TSPAN14_uc009xss.2_Intron|TSPAN14_uc001kci.3_Silent_p.F110F	NM_030927	NP_112189	Q8NG11	TSN14_HUMAN	tetraspanin 14 isoform 1	127						integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)			GGGAGTTCTTCGAGAGCAACA	0.582													6	51					0	0	0	0	T	82269158	T	T	82269158	2	4	133	1	0	0	0	0	0	0	0	1	16705	883	31	1		1	TSPAN14	10	82269158	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	22241913	82269158	53265589	92	23842											
FAM190B	54462	broad.mit.edu	37	chr10	86237392	86237392	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgcacttatgctgataaatAtacccaaacaccctggagac	15	9	6	11	0	0	2	0	1	0	1	0	3	0	2	2	1	4	2	2	1	6	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:86237392A>G	uc001kdh.1	+	9	2491	c.2297A>G	c.(2296-2298)TAT>TGT	p.Y766C	FAM190B_uc010qmd.1_Missense_Mutation_p.Y766C|FAM190B_uc001kdi.1_Translation_Start_Site|FAM190B_uc010qme.1_Missense_Mutation_p.Y193C	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	766										ovary(3)|skin(1)	4						GCTGATAAATATACCCAAACA	0.338													8	22					0	0	0	0	G	86237392	G	G	86237392	3	3	133	1	0	0	0	0	1	0	0	0	5550	449	16	5	2327	5	FAM190B	10	86237392	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	3968234	86237392	49297355	93	23843											
HTR7	3363	broad.mit.edu	37	chr10	92508650	92508650	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcttcagggcttcatgcatgCctgcagctgagagcttccgg	6	10	13	12	1	2	1	2	1	0	1	3	2	3	1	2	2	5	6	2	2	0	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:92508650C>A	uc001kha.2	-	2	1484	c.1241G>T	c.(1240-1242)GGC>GTC	p.G414V	HTR7_uc001kgz.2_Missense_Mutation_p.G414V|HTR7_uc001khb.2_Missense_Mutation_p.G414V	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	414	Cytoplasmic (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	TTCATGCATGCCTGCAGCTGA	0.498													7	145					8.12818e-05	8.82738e-05	1	0	A	92508650	A	A	92508650	3	1	133	1	0	0	0	0	1	0	0	0	7491	739	26	4	214	4	HTR7	10	92508650	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	6271258	92508650	43026097	94	23844											
RRP12	23223	broad.mit.edu	37	chr10	99123620	99123620	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaactactcacattcctgatGatcacatcttccattgggtc	10	13	6	12	0	3	2	2	2	1	0	6	3	5	2	2	1	2	0	2	1	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:99123620G>A	uc001knf.2	-	30	3697	c.3558C>T	c.(3556-3558)ATC>ATT	p.I1186I	RRP12_uc001kne.2_Silent_p.I201I|RRP12_uc009xvl.2_Silent_p.I303I|RRP12_uc009xvm.2_Silent_p.I904I|RRP12_uc010qou.1_Silent_p.I1125I|RRP12_uc009xvn.2_Silent_p.I1086I	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	1186						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CATTCCTGATGATCACATCTT	0.542													5	120					0	0	0	0	A	99123620	A	A	99123620	2	1	133	1	0	0	0	0	0	0	0	1	13751	1280	45	2		2	RRP12	10	99123620	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	6614970	99123620	36411127	95	23845											
HPSE2	60495	broad.mit.edu	37	chr10	100503694	100503694	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctggcgctgtacttcaacaGactcagggcactagaactgt	10	9	11	11	1	2	2	2	0	0	2	2	2	2	2	0	2	3	4	0	2	4	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:100503694G>A	uc001kpn.1	-	4	790	c.730C>T	c.(730-732)CTG>TTG	p.L244L	HPSE2_uc009xwc.1_Silent_p.L234L|HPSE2_uc001kpo.1_Intron|HPSE2_uc009xwd.1_Intron	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	244					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TACTTCAACAGACTCAGGGCA	0.418													19	42					0	0	0	0	A	100503694	A	A	100503694	2	1	133	1	0	0	0	0	0	0	0	1	7384	933	33	2		2	HPSE2	10	100503694	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	1380074	100503694	35031053	96	23846											
FANK1	92565	broad.mit.edu	37	chr10	127677183	127677183	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgctgtacagatttcgcctGaaggtcaccagcccctctgg	8	9	10	14	2	2	2	1	1	1	1	3	2	2	2	4	2	2	2	4	2	2	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr10:127677183G>A	uc001ljh.3	+	3	359	c.255G>A	c.(253-255)CTG>CTA	p.L85L	FANK1_uc010quk.1_Silent_p.L79L|FANK1_uc009yan.2_Silent_p.L85L|FANK1_uc001lji.2_Silent_p.L79L	NM_145235	NP_660278	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains	85	Fibronectin type-III.					cytoplasm|nucleus				ovary(1)	1		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				GATTTCGCCTGAAGGTCACCA	0.517													8	184					0	0	0	0	A	127677183	A	A	127677183	2	1	133	1	0	0	0	0	0	0	0	1	5704	1277	45	2		2	FANK1	10	127677183	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	27173489	127677183	7857564	97	23847											
DEAF1	10522	broad.mit.edu	37	chr11	688405	688405	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctgtgtggacgacaatcAgtgtcgctttttcggtgttc	6	15	11	9	3	2	0	1	0	1	0	5	2	2	1	0	2	0	2	0	2	1	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:688405A>C	uc001lqq.1	-	3	1136	c.443T>G	c.(442-444)CTG>CGG	p.L148R	DEAF1_uc009ycf.1_5'Flank	NM_021008	NP_066288	O75398	DEAF1_HUMAN	deformed epidermal autoregulatory factor 1	148					embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding				0		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GACGACAATCAGTGTCGCTTT	0.617													3	50					0	0	0	0	C	688405	C	C	688405	3	2	133	1	0	0	0	0	1	0	0	0	4397	188	7	5	1294	5	DEAF1	11	688405	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08		688405	134318111	98	23848											
MUC6	4588	broad.mit.edu	37	chr11	1017190	1017190	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggtgcctgttggcattgAgtggatggaggcagaagtgg	9	10	18	4	0	0	2	0	1	0	1	0	4	0	4	1	6	1	3	1	6	2	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:1017190A>G	uc001lsw.2	-	31	5662	c.5611T>C	c.(5611-5613)TCA>CCA	p.S1871P		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1871	Thr-rich.|2.|Approximate repeats.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTTGGCATTGAGTGGATGGAG	0.577													17	516					0	0	0	0	G	1017190	G	G	1017190	3	3	133	1	0	0	0	0	1	0	0	0	10033	304	11	5	1720	5	MUC6	11	1017190	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	328785	1017190	133989326	99	23849											
MUC5B	727897	broad.mit.edu	37	chr11	1261590	1261590	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccttcaccaccgcctgggtcCcccactccacgacaagtaag	9	6	7	19	2	1	0	1	0	0	0	3	1	3	0	7	1	0	1	7	1	2	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:1261590C>T	uc009ycr.1	+	46	6160	c.6034C>T	c.(6034-6036)CCC>TCC	p.P2012S	MUC5B_uc001ltb.2_Missense_Mutation_p.P1322S|MUC5B_uc001lta.2_Missense_Mutation_p.P987S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1319					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGCCTGGGTCCCCCACTCCAC	0.617													22	37					0	0	0	0	T	1261590	T	T	1261590	3	4	133	1	0	0	0	0	1	0	0	0	10032	623	22	4	4082	4	MUC5B	11	1261590	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	244400	1261590	133744926	100	23850											
NLRP14	338323	broad.mit.edu	37	chr11	7081273	7081273	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgatgtctttcggcatccaAgctgtaatcttcaggacttg	8	14	10	9	1	3	1	1	1	2	0	5	2	4	2	1	2	1	3	1	2	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:7081273A>T	uc001mfb.1	+	9	3105	c.2782A>T	c.(2782-2784)AGC>TGC	p.S928C		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	928					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TCGGCATCCAAGCTGTAATCT	0.433													60	115					0	0	0	0	T	7081273	T	T	7081273	3	4	133	1	0	0	0	0	1	0	0	0	10530	72	3	5	2812	5	NLRP14	11	7081273	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	5819683	7081273	127925243	101	23851											
EIF4G2	1982	broad.mit.edu	37	chr11	10825924	10825924	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcagacatagctgagcataCagtgagctatactttggctc	11	10	10	10	1	0	3	0	2	0	1	1	3	0	3	0	1	5	5	0	1	4	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:10825924C>A	uc001mjc.2	-	6	810	c.393G>T	c.(391-393)CTG>CTT	p.L131L	EIF4G2_uc001mjb.2_5'UTR|EIF4G2_uc009ygf.2_5'UTR|EIF4G2_uc001mjd.2_Silent_p.L131L|EIF4G2_uc001mjf.1_5'UTR|SNORD97_uc009yge.2_5'Flank	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	131	MIF4G.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GCTGAGCATACAGTGAGCTAT	0.443													37	76					3.21399e-22	3.79665e-22	1	0	A	10825924	A	A	10825924	2	1	133	1	0	0	0	0	0	0	0	1	5061	465	17	4		4	EIF4G2	11	10825924	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	3744651	10825924	124180592	102	23852											
NAV2	89797	broad.mit.edu	37	chr11	20117234	20117237	+	Frame_Shift_Del	DEL	TCTT	-	-																															ttaggattccagaccacatcTctttcttattggctgcattg																								rs34775480	byFrequency	TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:20117234_20117237delTCTT	uc001mpr.3	+	30	6303_6306	c.5942_5945delTCTT	c.(5941-5946)CTCTTTfs	p.L1981fs	NAV2_uc001mpp.2_Frame_Shift_Del_p.L1914fs|NAV2_uc009yhx.2_Frame_Shift_Del_p.L1042fs|NAV2_uc009yhz.2_Frame_Shift_Del_p.L623fs|NAV2_uc001mpu.2_Frame_Shift_Del_p.L416fs	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	2037_2038						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						AGACCACATCTCTTTCTTATTGGC	0.461													---	---	---								-	20117237	-	-	20117234	7	5	133	1	0	1	0	1	0	0	0	0	10237	1551	54	0	6169	0	NAV2	11	20117234	Frame_Shift_Del	DEL	TCTT	TCGA-CR-6491-01A-11D-1870-08	9291310	20117234	114889282	103	23853											
LRRC4C	57689	broad.mit.edu	37	chr11	40137567	40137567	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagtgcttgaagctgttcacTttgatgatctggatttggtt	8	17	11	5	0	2	3	1	3	1	0	2	4	2	4	0	2	2	4	0	2	2	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr11:40137567T>A	uc001mxa.1	-	2	2240	c.276A>T	c.(274-276)AAA>AAT	p.K92N	LRRC4C_uc001mxc.1_Missense_Mutation_p.K88N|LRRC4C_uc001mxd.1_Missense_Mutation_p.K88N|LRRC4C_uc001mxb.1_Missense_Mutation_p.K88N	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	92	LRR 1.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				AGCTGTTCACTTTGATGATCT	0.473													15	49					0	0	0	0	A	40137567	A	A	40137567	3	1	133	1	0	0	0	0	1	0	0	0	9058	1606	56	5	1650	5	LRRC4C	11	40137567	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	20020333	40137567	94868949	104	23854											
SLC6A13	6540	broad.mit.edu	37	chr12	336790	336790	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgtcaggcacccaagacaGatggcgaaggagaagaatat	15	5	13	8	1	1	4	1	0	0	4	1	6	1	4	1	3	0	2	1	3	5	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:336790G>A	uc001qic.1	-	8	929	c.876C>T	c.(874-876)ATC>ATT	p.I292I	SLC6A13_uc009zdj.1_Silent_p.I292I|SLC6A13_uc010sdl.1_Silent_p.I200I|SLC6A13_uc010sdm.1_Silent_p.I173I	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	292	Helical; Name=6; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			ACCCAAGACAGATGGCGAAGG	0.562													6	47					0	0	0	0	A	336790	A	A	336790	2	1	133	1	0	0	0	0	0	0	0	1	14740	932	33	2		2	SLC6A13	12	336790	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08		336790	133515105	105	23855											
NOP2	4839	broad.mit.edu	37	chr12	6666180	6666180	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taagatagcagcagctggctGttgcccctggactgagattt	9	11	12	9	0	0	2	0	1	0	2	0	4	0	3	2	2	4	5	2	2	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:6666180G>C	uc001qph.1	-	16	2586	c.2406C>G	c.(2404-2406)AAC>AAG	p.N802K	IFFO1_uc001qpe.1_5'Flank|IFFO1_uc010sfe.1_5'Flank|IFFO1_uc001qpf.1_5'Flank|IFFO1_uc001qpc.1_5'Flank|IFFO1_uc001qpd.1_5'Flank|NOP2_uc009zeq.1_3'UTR|NOP2_uc001qpi.1_Missense_Mutation_p.N802K|NOP2_uc001qpj.1_Missense_Mutation_p.N231K	NM_001033714	NP_001028886	P46087	NOP2_HUMAN	nucleolar protein 1, 120kDa	806					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						GCAGCTGGCTGTTGCCCCTGG	0.557													18	32					0	0	0	0	C	6666180	C	C	6666180	3	2	133	1	0	0	0	0	1	0	0	0	10592	1368	48	4	24	4	NOP2	12	6666180	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	6329390	6666180	127185715	106	23856											
LPCAT3	10162	broad.mit.edu	37	chr12	7086775	7086775	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctacctgtctttccacaatAacaatgaggaattccatctg	12	12	5	12	0	2	1	0	1	2	0	4	2	4	2	4	1	2	0	4	1	5	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:7086775A>T	uc001qsi.2	-	10	1287	c.1173T>A	c.(1171-1173)GTT>GTA	p.V391V	EMG1_uc010sfv.1_Intron|LPCAT3_uc010sfw.1_Silent_p.V285V|LPCAT3_uc009zfp.2_RNA|LPCAT3_uc010sfx.1_RNA|LPCAT3_uc009zfq.1_Silent_p.V249V	NM_005768	NP_005759	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	391					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			ovary(1)	1						TTTCCACAATAACAATGAGGA	0.547													47	63					0	0	0	0	T	7086775	T	T	7086775	2	4	133	1	0	0	0	0	0	0	0	1	8962	349	13	5		5	LPCAT3	12	7086775	Silent	SNP	A	TCGA-CR-6491-01A-11D-1870-08	420595	7086775	126765120	107	23857											
GALNT6	11226	broad.mit.edu	37	chr12	51773260	51773260	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctgtggtggccgttcccaGaagggcttcagttcagctgg	5	11	14	11	1	2	1	2	0	0	1	4	1	4	1	3	4	1	4	3	4	1	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:51773260G>A	uc001ryk.2	-	2	531	c.306C>T	c.(304-306)TTC>TTT	p.F102F	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Silent_p.F102F|GALNT6_uc010snh.1_Silent_p.F102F	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	102	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GCCGTTCCCAGAAGGGCTTCA	0.567													5	118					0	0	0	0	A	51773260	A	A	51773260	2	1	133	1	0	0	0	0	0	0	0	1	6252	933	33	2		2	GALNT6	12	51773260	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	44686485	51773260	82078635	108	23858											
ESYT1	23344	broad.mit.edu	37	chr12	56532256	56532257	+	In_Frame_Ins	INS	-	TATATGGAG	TATATGGAG																															ctgcggccctgctatccatcINStatatggagcgggcagagga																										TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:56532256_56532257insTATATGGAG	uc001sjq.2	+	22	2456_2457	c.2406_2407insTATATGGAG	c.(2404-2409)insTATATGGAG	p.805_806insYME	ESYT1_uc001sjr.2_In_Frame_Ins_p.815_816insYME	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	805_806	C2 4.					integral to membrane		p.E805E(1)		ovary(4)|skin(1)	5						TGCTATCCATCTATATGGAGCG	0.609													---	---	---								TATATGGAG	56532257	TATATGGAG	TATATGGAG	56532256	7	5	133	1	0	1	1	0	0	0	0	0	5288	903	32	0	2522	0	ESYT1	12	56532256	In_Frame_Ins	INS	-	TCGA-CR-6491-01A-11D-1870-08	4758996	56532256	77319639	109	23859											
MBD6	114785	broad.mit.edu	37	chr12	57919712	57919712	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggcaccccccttccttgctAgcagcctactctctgcagcg	5	9	9	18	1	1	0	0	0	1	0	3	0	2	0	5	1	6	4	5	1	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:57919712A>T	uc001soj.1	+	6	1185	c.961A>T	c.(961-963)AGC>TGC	p.S321C	MBD6_uc001sok.1_Missense_Mutation_p.S188C|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	321	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CTTCCTTGCTAGCAGCCTACT	0.692													15	27					0	0	0	0	T	57919712	T	T	57919712	3	4	133	1	0	0	0	0	1	0	0	0	9401	420	15	5	975	5	MBD6	12	57919712	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	1387456	57919712	75932183	110	23860											
ATXN2	6311	broad.mit.edu	37	chr12	111948230	111948230	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctgttcgatgcaggactaGcaggcgtaggagatgcagct	9	9	14	9	2	1	1	0	0	1	1	2	4	1	2	0	3	4	6	0	3	2	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:111948230G>T	uc001tsj.2	-	12	2357	c.2195C>A	c.(2194-2196)GCT>GAT	p.A732D	ATXN2_uc001tsh.2_Missense_Mutation_p.A467D|ATXN2_uc001tsi.2_Missense_Mutation_p.A443D|ATXN2_uc001tsk.2_RNA	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	732	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						TGCAGGACTAGCAGGCGTAGG	0.493													12	214					0.00136819	0.00144699	1	0	T	111948230	T	T	111948230	3	4	133	1	0	0	0	0	1	0	0	0	1213	971	34	4	1802	4	ATXN2	12	111948230	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	54028518	111948230	21903665	111	23861											
OAS1	4938	broad.mit.edu	37	chr12	113354483	113354483	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgcatctactggacaaagtAttatgactttaaaaacccca	15	11	5	10	0	1	1	0	1	1	0	1	2	1	2	2	1	3	2	2	1	7	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:113354483A>G	uc001tud.2	+	4	930	c.824A>G	c.(823-825)TAT>TGT	p.Y275C	OAS1_uc010syn.1_Missense_Mutation_p.Y274C|OAS1_uc010syo.1_3'UTR|OAS1_uc001tub.2_Missense_Mutation_p.Y275C|OAS1_uc001tuc.2_Missense_Mutation_p.Y275C|OAS1_uc009zwf.2_Missense_Mutation_p.Y274C	NM_016816	NP_058132	P00973	OAS1_HUMAN	2',5'-oligoadenylate synthetase 1 isoform 1	275					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(2)	2						TGGACAAAGTATTATGACTTT	0.443													39	46					0	0	0	0	G	113354483	G	G	113354483	3	3	133	1	0	0	0	0	1	0	0	0	10853	449	16	5	838	5	OAS1	12	113354483	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	1406253	113354483	20497412	112	23862											
GLT1D1	144423	broad.mit.edu	37	chr12	129360459	129360459	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctctgtattttttgataaagGgcccatctagaggctgcagg	9	13	11	8	0	2	2	0	1	2	1	2	2	2	2	1	3	1	3	1	3	4	6			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:129360459G>A	uc010tbh.1	+	2	45	c.36G>A	c.(34-36)CTG>CTA	p.L12L	GLT1D1_uc001uhx.1_Silent_p.R23R|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	Error:Variant_position_missing_in_Q96MS3_after_alignment					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		TTTGATAAAGGGCCCATCTAG	0.398													55	96					0	0	0	0	A	129360459	A	A	129360459	2	1	133	1	0	0	0	0	0	0	0	1	6502	1246	43	4		4	GLT1D1	12	129360459	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	16005976	129360459	4491436	113	23863											
EP400	57634	broad.mit.edu	37	chr12	132446187	132446187	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccactcacgtctgtggggaaCacgggaatgaagaaggttcc	11	7	13	10	2	2	2	1	1	1	1	3	4	3	4	2	4	1	1	2	4	4	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr12:132446187C>A	uc001ujn.2	+	1	1058	c.1023C>A	c.(1021-1023)AAC>AAA	p.N341K	EP400_uc001ujl.2_Missense_Mutation_p.N341K|EP400_uc001ujm.2_Missense_Mutation_p.N341K|EP400_uc001ujj.1_Missense_Mutation_p.N341K|EP400_uc001ujk.2_Missense_Mutation_p.N341K	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	341					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CTGTGGGGAACACGGGAATGA	0.612													8	10					1.58986e-06	1.76457e-06	1	0	A	132446187	A	A	132446187	3	1	133	1	0	0	0	0	1	0	0	0	5173	477	17	4	1025	4	EP400	12	132446187	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	3085728	132446187	1405708	114	23864											
FNDC3A	22862	broad.mit.edu	37	chr13	49762701	49762701	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaccagggaacatctttgtGatcgactgaatccaggctgt	10	11	10	10	1	1	2	0	2	1	0	3	4	2	3	2	2	2	1	2	2	3	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:49762701G>C	uc001vcm.2	+	17	2181	c.1876G>C	c.(1876-1878)GAT>CAT	p.D626H	FNDC3A_uc001vcn.2_Missense_Mutation_p.D626H|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.D552H|FNDC3A_uc001vcq.2_Missense_Mutation_p.D570H	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	626	Fibronectin type-III 4.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ACATCTTTGTGATCGACTGAA	0.393													7	171					0	0	0	0	C	49762701	C	C	49762701	3	2	133	1	0	0	0	0	1	0	0	0	6001	1290	45	2	1949	2	FNDC3A	13	49762701	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08		49762701	65407177	115	23865											
ATP7B	540	broad.mit.edu	37	chr13	52536026	52536026	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgttggggtttctctgggcCagggaagcatgaaagccaat	9	9	15	8	1	1	1	0	1	1	0	2	2	1	2	2	4	2	3	2	4	3	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:52536026C>T	uc001vfw.2	-	6	2050	c.1893G>A	c.(1891-1893)CTG>CTA	p.L631L	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Intron|ATP7B_uc001vfy.2_Silent_p.L520L|ATP7B_uc010tgt.1_Silent_p.L631L|ATP7B_uc010tgu.1_Silent_p.L631L|ATP7B_uc010tgv.1_Silent_p.L631L|ATP7B_uc001vfv.2_5'Flank|ATP7B_uc010tgs.1_5'UTR|ATP7B_uc010tgw.1_Intron	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	631	HMA 6.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TTCTCTGGGCCAGGGAAGCAT	0.433									Wilson_disease				12	43					0	0	0	0	T	52536026	T	T	52536026	2	4	133	1	0	0	0	0	0	0	0	1	1193	581	21	4		4	ATP7B	13	52536026	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	2773325	52536026	62633852	116	23866											
SLITRK5	26050	broad.mit.edu	37	chr13	88329424	88329424	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacgaggtgatctgtaaggCgcccaaaaaattcgctgaga	13	7	13	8	3	1	2	0	2	1	1	2	5	1	3	1	3	0	2	1	3	4	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:88329424C>T	uc001vln.2	+	2	2000	c.1781C>T	c.(1780-1782)GCG>GTG	p.A594V	SLITRK5_uc010tic.1_Missense_Mutation_p.A353V	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	594	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ATCTGTAAGGCGCCCAAAAAA	0.532													23	136					0	0	0	0	T	88329424	T	T	88329424	3	4	133	1	0	0	0	0	1	0	0	0	14810	768	27	1	1783	1	SLITRK5	13	88329424	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	35793398	88329424	26840454	117	23867											
TMTC4	84899	broad.mit.edu	37	chr13	101287320	101287320	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggctccgaatccaaaagtCagcagcacacagtacccaac	15	4	8	14	1	1	0	1	0	0	0	3	1	3	0	3	1	4	4	3	1	5	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:101287320C>T	uc001vou.2	-	10	1435	c.1275G>A	c.(1273-1275)CTG>CTA	p.L425L	TMTC4_uc001vot.2_Silent_p.L444L|TMTC4_uc010tja.1_Silent_p.L314L|TMTC4_uc001vov.1_Silent_p.L170L|TMTC4_uc001vow.1_Silent_p.L208L	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	425	Helical; (Potential).					integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ATCCAAAAGTCAGCAGCACAC	0.527													24	40					0	0	0	0	T	101287320	T	T	101287320	2	4	133	1	0	0	0	0	0	0	0	1	16329	813	29	2		2	TMTC4	13	101287320	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	12957896	101287320	13882558	118	23868											
TMCO3	55002	broad.mit.edu	37	chr13	114152804	114152804	+	Frame_Shift_Del	DEL	A	-	-																															cggatcgtctggaggaagagAtagaggaacatgcttttgac																								rs143854308		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr13:114152804delA	uc001vtu.3	+	3	953	c.592delA	c.(592-594)ATAfs	p.I198fs	TMCO3_uc001vtt.3_Frame_Shift_Del_p.I198fs	NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	198	Potential.					integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GGAGGAAGAGATAGAGGAACA	0.418													---	---	---								-	114152804	-	-	114152804	7	5	133	1	0	1	0	1	0	0	0	0	16063	333	12	0	598	0	TMCO3	13	114152804	Frame_Shift_Del	DEL	A	TCGA-CR-6491-01A-11D-1870-08	12865484	114152804	1017074	119	23869											
JUB	84962	broad.mit.edu	37	chr14	23451169	23451169	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaatcggggggcaacgactGaggtagaggcaaggcccggg	12	3	18	8	3	0	2	0	1	0	1	1	3	0	2	1	7	1	3	1	7	5	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:23451169G>A	uc001whz.2	-	1	683	c.307C>T	c.(307-309)CAG>TAG	p.Q103*		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	103	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		GGCAACGACTGAGGTAGAGGC	0.706													7	1					0	0	0	0	A	23451169	A	A	23451169	4	1	133	1	0	0	0	0	0	1	0	0	8007	1299	45	2	1341	2	JUB	14	23451169	Nonsense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08		23451169	83898371	120	23870											
RALGAPA1	253959	broad.mit.edu	37	chr14	36103939	36103939	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggattgctaaaacactgagCtccataaacacacccatgta	15	9	6	11	0	0	1	0	1	0	0	1	2	1	2	2	1	4	3	2	1	5	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:36103939C>A	uc001wti.2	-	32	4709	c.4318G>T	c.(4318-4320)GCT>TCT	p.A1440S	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.A1440S|RALGAPA1_uc010tpv.1_Missense_Mutation_p.A1453S|RALGAPA1_uc010tpw.1_Missense_Mutation_p.A1487S	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1440	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						AAACACTGAGCTCCATAAACA	0.343													7	45					5.18039e-06	5.68717e-06	1	0	A	36103939	A	A	36103939	3	1	133	1	0	0	0	0	1	0	0	0	13078	797	28	4	1981	4	RALGAPA1	14	36103939	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	12652770	36103939	71245601	121	23871											
PSMC6	5706	broad.mit.edu	37	chr14	53177865	53177865	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaagagttgctttggataTgactacactaactatcatga	15	12	7	7	0	1	3	1	2	0	1	1	4	1	4	0	1	4	2	0	1	6	6			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:53177865T>A	uc010tqx.1	+	5	347	c.347T>A	c.(346-348)ATG>AAG	p.M116K	PSMC6_uc010tqw.1_Missense_Mutation_p.M82K	NM_002806	NP_002797	P62333	PRS10_HUMAN	proteasome 26S ATPase subunit 6	102					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			lung(1)	1	Breast(41;0.176)					GCTTTGGATATGACTACACTA	0.328													49	31					0	0	0	0	A	53177865	A	A	53177865	3	1	133	1	0	0	0	0	1	0	0	0	12753	1464	51	5	365	5	PSMC6	14	53177865	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	17073926	53177865	54171675	122	23872											
ANGEL1	23357	broad.mit.edu	37	chr14	77257651	77257652	+	Frame_Shift_Ins	INS	-	GGCT	GGCT																															aaggttacctggagaaggcaINSggctcaagctccgatgcatc																										TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:77257651_77257652insGGCT	uc001xsv.2	-	8	1789_1790	c.1676_1677insAGCC	c.(1675-1677)CCTfs	p.P559fs	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	559										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TGGAGAAGGCAGGCTCAAGCTC	0.505													---	---	---								GGCT	77257652	GGCT	GGCT	77257651	7	5	133	1	0	1	1	0	0	0	0	0	608	175	7	0	347	0	ANGEL1	14	77257651	Frame_Shift_Ins	INS	-	TCGA-CR-6491-01A-11D-1870-08	24079786	77257651	30091889	123	23873											
TRIP11	9321	broad.mit.edu	37	chr14	92471192	92471192	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaactgatcaatctgtttaGttaaagatatattcttttca	14	17	4	6	0	4	2	2	1	2	1	4	2	4	2	0	0	1	2	0	0	7	8			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr14:92471192G>C	uc001xzy.2	-	11	3916	c.3128C>G	c.(3127-3129)ACT>AGT	p.T1043S	TRIP11_uc010auf.1_Missense_Mutation_p.T779S	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1043	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		AATCTGTTTAGTTAAAGATAT	0.318			T	PDGFRB	AML								23	35					0	0	0	0	C	92471192	C	C	92471192	3	2	133	1	0	0	0	0	1	0	0	0	16622	1029	36	4	2855	4	TRIP11	14	92471192	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	15213541	92471192	14878348	124	23874											
CEP152	22995	broad.mit.edu	37	chr15	49083442	49083442	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaataggtacctgttcttCattgacttttaatgcttgta	11	18	6	6	0	2	1	1	1	1	0	2	1	2	1	1	1	2	4	1	1	6	10			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr15:49083442C>T	uc001zwy.2	-	8	998	c.964G>A	c.(964-966)GAA>AAA	p.E322K	CEP152_uc001zwz.2_Missense_Mutation_p.E322K|CEP152_uc001zxa.1_Missense_Mutation_p.E229K	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	322	Potential.				centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		ACCTGTTCTTCATTGACTTTT	0.299													17	41					0	0	0	0	T	49083442	T	T	49083442	3	4	133	1	0	0	0	0	1	0	0	0	3263	835	29	2	4076	2	CEP152	15	49083442	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08		49083442	53447950	125	23875											
WDR72	256764	broad.mit.edu	37	chr15	53889439	53889439	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatgtgttgttgaacttcCgccaagagaacagcttgtat	10	14	9	8	1	1	2	1	1	0	1	2	3	2	2	2	0	3	4	2	0	4	6			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr15:53889439C>T	uc002acj.2	-	18	3027	c.2985G>A	c.(2983-2985)GCG>GCA	p.A995A		NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	995										lung(1)|skin(1)	2				all cancers(107;0.0511)		GTTGAACTTCCGCCAAGAGAA	0.378													9	148					0	0	0	0	T	53889439	T	T	53889439	2	4	133	1	0	0	0	0	0	0	0	1	17390	639	23	1		1	WDR72	15	53889439	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	4805997	53889439	48641953	126	23876											
IQCH	64799	broad.mit.edu	37	chr15	67757466	67757466	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggctcctgttttaatcaggTgtgggcaaccggccttaacc	7	11	11	12	2	1	0	1	0	0	0	2	0	2	0	4	4	2	3	4	4	3	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr15:67757466T>C	uc002aqo.1	+	17	2554	c.2507T>C	c.(2506-2508)GTG>GCG	p.V836A	IQCH_uc002aqq.1_Missense_Mutation_p.V493A|IQCH_uc002aqp.1_Missense_Mutation_p.V497A|uc002aqr.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	836										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		TTTAATCAGGTGTGGGCAACC	0.517													5	80					0	0	0	0	C	67757466	C	C	67757466	3	2	133	1	0	0	0	0	1	0	0	0	7850	1710	59	5	2701	5	IQCH	15	67757466	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	13868027	67757466	34773926	127	23877											
AKAP13	11214	broad.mit.edu	37	chr15	86201776	86201776	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcattttcagttcaatgcGagttcttggggatgttgtca	8	17	10	6	1	5	0	4	0	1	0	5	2	5	1	0	2	1	3	0	2	1	7			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr15:86201776G>T	uc002blv.1	+	12	4924	c.4754G>T	c.(4753-4755)CGA>CTA	p.R1585L	AKAP13_uc002blt.1_Intron|AKAP13_uc002blu.1_Intron|AKAP13_uc010bnf.1_Intron|AKAP13_uc002blw.1_Intron|AKAP13_uc010bne.1_Missense_Mutation_p.R238L	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1585					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						AGTTCAATGCGAGTTCTTGGG	0.433													6	131					0.00307968	0.00322329	1	0	T	86201776	T	T	86201776	3	4	133	1	0	0	0	0	1	0	0	0	449	1058	37	3	4796	3	AKAP13	15	86201776	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	18444310	86201776	16329616	128	23878											
NOXO1	124056	broad.mit.edu	37	chr16	2030459	2030459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgccacgcgctctgcagtcgCcagcagcctccgagaatagg	8	6	12	15	4	1	1	0	0	1	1	3	2	2	1	4	1	4	3	4	1	2	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:2030459C>T	uc002cnx.2	-	4	329	c.325G>A	c.(325-327)GCG>ACG	p.A109T	NOXO1_uc002cnz.2_Missense_Mutation_p.A103T|NOXO1_uc002coa.2_Missense_Mutation_p.A108T|NOXO1_uc002cny.2_Missense_Mutation_p.A104T	NM_172168	NP_751908	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1 isoform c	109	PX.				cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity				0						TCTGCAGTCGCCAGCAGCCTC	0.682													14	24					0	0	0	0	T	2030459	T	T	2030459	3	4	133	1	0	0	0	0	1	0	0	0	10615	739	26	4	825	4	NOXO1	16	2030459	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08		2030459	88324294	129	23879											
MMP25	64386	broad.mit.edu	37	chr16	3100445	3100445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggacagctaccccttcgacGggttggggggcaccctagcc	7	6	14	14	2	0	0	0	0	0	0	1	2	0	1	4	5	3	3	4	5	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:3100445G>A	uc002cth.2	+	4	796	c.559G>A	c.(559-561)GGG>AGG	p.G187R	MMP25_uc002cti.1_Missense_Mutation_p.G123R	NM_022468	NP_071913	Q9NPA2	MMP25_HUMAN	matrix metalloproteinase 25 preproprotein	187					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0						CCCCTTCGACGGGTTGGGGGG	0.612													8	41					0	0	0	0	A	3100445	A	A	3100445	3	1	133	1	0	0	0	0	1	0	0	0	9715	1116	39	1	573	1	MMP25	16	3100445	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	1069986	3100445	87254308	130	23880											
ACSM3	6296	broad.mit.edu	37	chr16	20781491	20781491	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatttctccaactatgaatcCatgaaacaggacttcaaact	16	11	4	10	0	2	2	1	2	1	0	4	3	3	3	2	1	3	0	2	1	6	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:20781491C>T	uc002dhr.2	+	2	322	c.135C>T	c.(133-135)TCC>TCT	p.S45S	ACSM3_uc002dhq.2_Silent_p.S45S|ACSM3_uc010vba.1_Silent_p.S37S	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	45					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						ACTATGAATCCATGAAACAGG	0.443													31	49					0	0	0	0	T	20781491	T	T	20781491	2	4	133	1	0	0	0	0	0	0	0	1	185	581	21	4		4	ACSM3	16	20781491	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	17681046	20781491	69573262	131	23881											
LYRM1	57149	broad.mit.edu	37	chr16	20927015	20927015	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atactaaatgaagccagaacGctgttccggaaaaacaaaaa	20	6	7	8	2	0	2	0	1	0	1	1	3	1	3	2	1	4	2	2	1	9	3	rs138841536	by1000genomes	TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:20927015G>A	uc010bwj.2	+	2	439	c.138G>A	c.(136-138)ACG>ACA	p.T46T	LYRM1_uc010bwi.1_RNA|LYRM1_uc010bwk.2_Intron|LYRM1_uc002dia.3_Silent_p.T46T|LYRM1_uc010bwl.2_Silent_p.T46T|LYRM1_uc010bwm.2_Intron|LYRM1_uc002dib.2_Silent_p.T46T	NM_020424	NP_065157	O43325	LYRM1_HUMAN	LYR motif containing 1	46						nucleus					0						AAGCCAGAACGCTGTTCCGGA	0.423													26	43					0	0	0	0	A	20927015	A	A	20927015	2	1	133	1	0	0	0	0	0	0	0	1	9170	1074	38	1		1	LYRM1	16	20927015	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	145524	20927015	69427738	132	23882											
GTF3C1	2975	broad.mit.edu	37	chr16	27476145	27476145	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacctccagcacctgatgctGctccaggagggcctggggag	7	6	15	13	0	0	1	0	1	0	0	2	4	2	3	5	4	3	3	5	4	0	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:27476145G>A	uc002dov.1	-	34	5408	c.5368C>T	c.(5368-5370)CAG>TAG	p.Q1790*	GTF3C1_uc002dou.2_Nonsense_Mutation_p.Q1790*	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1790						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						ACCTGATGCTGCTCCAGGAGG	0.677													9	17					0	0	0	0	A	27476145	A	A	27476145	4	1	133	1	0	0	0	0	0	1	0	0	6911	1328	46	4	977	4	GTF3C1	16	27476145	Nonsense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	6549130	27476145	62878608	133	23883											
CHST5	23563	broad.mit.edu	37	chr16	75564112	75564112	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcacacgatcctcgccgccGgctggggatgagggccctgg	5	6	16	14	4	0	1	0	1	0	0	2	3	1	2	4	5	1	2	4	5	0	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr16:75564112G>A	uc002fei.2	-	3	1566	c.171C>T	c.(169-171)GCC>GCT	p.A57A	CHST5_uc002fej.1_Silent_p.A63A	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	57	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						CCTCGCCGCCGGCTGGGGATG	0.647													8	16					0	0	0	0	A	75564112	A	A	75564112	2	1	133	1	0	0	0	0	0	0	0	1	3422	1103	39	1		1	CHST5	16	75564112	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	48087967	75564112	14790641	134	23884											
GSG2	83903	broad.mit.edu	37	chr17	3627636	3627636	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcggcccgctccgacttcCgcccttccccagccgcgact	3	7	9	22	6	0	0	0	0	0	0	3	2	3	0	7	1	2	1	7	1	0	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:3627636C>T	uc002fwp.2	+	1	440	c.407C>T	c.(406-408)CCG>CTG	p.P136L	ITGAE_uc002fwo.3_Intron|ITGAE_uc002fwn.3_5'Flank	NM_031965	NP_114171	Q8TF76	HASP_HUMAN	haspin	136					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity				0						CTCCGACTTCCGCCCTTCCCC	0.726													3	5					0	0	0	0	T	3627636	T	T	3627636	3	4	133	1	0	0	0	0	1	0	0	0	6861	652	23	1	409	1	GSG2	17	3627636	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08		3627636	77567574	135	23885											
TP53	7157	broad.mit.edu	37	chr17	7577572	7577572	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgcaggaactgttacacaTgtagttgtagtggatggtgg	10	12	14	5	0	0	0	0	0	0	0	0	2	0	2	0	4	3	5	0	4	4	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:7577572T>C	uc002gim.2	-	7	903	c.709A>G	c.(709-711)ATG>GTG	p.M237V	TP53_uc002gig.1_Missense_Mutation_p.M237V|TP53_uc002gih.2_Missense_Mutation_p.M237V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.M105V|TP53_uc010cng.1_Missense_Mutation_p.M105V|TP53_uc002gii.1_Missense_Mutation_p.M105V|TP53_uc010cnh.1_Missense_Mutation_p.M237V|TP53_uc010cni.1_Missense_Mutation_p.M237V|TP53_uc002gij.2_Missense_Mutation_p.M237V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.M144V|TP53_uc002gio.2_Missense_Mutation_p.M105V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	237	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		M -> L (in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> I (in LFS; germline mutation and in sporadic cancers; somatic mutation).|M -> R (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M237I(97)|p.M237K(8)|p.0?(7)|p.M237V(6)|p.M237fs*10(4)|p.M237R(3)|p.M237T(2)|p.M237L(2)|p.Y236_M237delYM(1)|p.Y236_M237insXX(1)|p.M237_N239delMCN(1)|p.H233fs*6(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.M237fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTGTTACACATGTAGTTGTAG	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	54					0	0	0	0	C	7577572	C	C	7577572	3	2	133	1	0	0	0	0	1	0	0	0	16448	1464	51	5	581	5	TP53	17	7577572	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	3949936	7577572	73617638	136	23886											
TP53	7157	broad.mit.edu	37	chr17	7578394	7578394	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctatctgagcagcgctcaTggtgggggcagcgcctcaca	7	7	14	13	3	3	1	2	1	1	0	3	1	3	1	1	3	3	4	1	3	1	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:7578394T>C	uc002gim.2	-	5	730	c.536A>G	c.(535-537)CAT>CGT	p.H179R	TP53_uc002gig.1_Missense_Mutation_p.H179R|TP53_uc002gih.2_Missense_Mutation_p.H179R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47R|TP53_uc010cng.1_Missense_Mutation_p.H47R|TP53_uc002gii.1_Missense_Mutation_p.H47R|TP53_uc010cnh.1_Missense_Mutation_p.H179R|TP53_uc010cni.1_Missense_Mutation_p.H179R|TP53_uc002gij.2_Missense_Mutation_p.H179R|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86R|TP53_uc002gio.2_Missense_Mutation_p.H47R|TP53_uc010vug.1_Missense_Mutation_p.H140R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	39					0	0	0	0	C	7578394	C	C	7578394	3	2	133	1	0	0	0	0	1	0	0	0	16448	1464	51	5	762	5	TP53	17	7578394	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	822	7578394	73616816	137	23887											
PFAS	5198	broad.mit.edu	37	chr17	8170154	8170154	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggtgctgaagcgttacCgggatgctggcctccattgc	6	9	13	13	2	0	1	0	1	0	0	1	2	1	2	4	3	5	3	4	3	2	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:8170154C>G	uc002gkr.2	+	23	3046	c.2905C>G	c.(2905-2907)CGG>GGG	p.R969G	PFAS_uc010vuv.1_Missense_Mutation_p.R545G|PFAS_uc002gks.2_Missense_Mutation_p.R48G	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	969					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAAGCGTTACCGGGATGCTGG	0.662													15	28					0	0	0	0	G	8170154	G	G	8170154	3	3	133	1	0	0	0	0	1	0	0	0	11809	643	23	3	2991	3	PFAS	17	8170154	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	591760	8170154	73025056	138	23888											
DNAH9	1770	broad.mit.edu	37	chr17	11648369	11648369	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaggcgatagtggatctgAagctccaggctgaggacaac	12	6	15	8	1	1	2	0	2	1	0	2	6	2	5	1	5	2	2	1	5	4	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:11648369A>T	uc002gne.2	+	31	6435	c.6367A>T	c.(6367-6369)AAG>TAG	p.K2123*	DNAH9_uc010coo.2_Nonsense_Mutation_p.K1417*	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2123	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGTGGATCTGAAGCTCCAGGC	0.512													39	73					0	0	0	0	T	11648369	T	T	11648369	4	4	133	1	0	0	0	0	0	1	0	0	4630	247	9	5	6489	5	DNAH9	17	11648369	Nonsense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	3478215	11648369	69546841	139	23889											
GOSR1	9527	broad.mit.edu	37	chr17	28808253	28808253	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caagttacagtcatagcagtAcccgagatggaagacgcgac	14	6	11	10	3	1	2	1	0	0	2	1	5	1	3	1	1	3	3	1	1	5	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:28808253A>T	uc002hfe.2	+	2	150	c.124A>T	c.(124-126)ACC>TCC	p.T42S	GOSR1_uc002hfd.2_Missense_Mutation_p.T42S|GOSR1_uc002hff.2_5'UTR|GOSR1_uc002hfc.1_Missense_Mutation_p.T42S	NM_004871	NP_004862	O95249	GOSR1_HUMAN	golgi SNAP receptor complex member 1 isoform 1	42	Cytoplasmic (Potential).				intra-Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|SNARE complex	SNAP receptor activity				0						TCATAGCAGTACCCGAGATGG	0.373													27	47					0	0	0	0	T	28808253	T	T	28808253	3	4	133	1	0	0	0	0	1	0	0	0	6614	391	14	5	130	5	GOSR1	17	28808253	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	17159884	28808253	52386957	140	23890											
RAD51L3	5892	broad.mit.edu	37	chr17	33445520	33445520	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaagtacacacacaaacCtgccaatgccagtggacagg	14	4	8	15	0	0	0	0	0	0	0	0	1	0	1	5	2	4	1	5	2	4	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:33445520C>A	uc002hir.2	-	3	519	c.263G>T	c.(262-264)AGT>ATT	p.S88I	RFFL_uc002hiq.2_Intron|RAD51L3_uc010wcd.1_Intron|RAD51L3_uc002his.2_Intron|RAD51L3_uc010ctk.2_Translation_Start_Site|RAD51L3_uc010wce.1_5'UTR|RAD51L3_uc002hit.2_Intron|RAD51L3_uc002hiu.2_Intron|RAD51L3_uc010wcf.1_RNA|RAD51L3_uc002hiw.1_RNA|RAD51L3_uc002hiv.1_RNA|RAD51L3_uc010ctl.1_RNA|RAD51L3_uc010ctm.1_RNA	NM_002878	NP_002869	O75771	RA51D_HUMAN	RAD51-like 3 isoform 1	88					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		ACACACAAACCTGCCAATGCC	0.557								Direct_reversal_of_damage|Homologous_recombination					13	93					6.72482e-11	7.71826e-11	1	0	A	33445520	A	A	33445520	3	1	133	1	0	0	0	0	1	0	0	0	13055	695	24	4	938	4	RAD51L3	17	33445520	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	4637267	33445520	47749690	141	23891											
AMAC1	146861	broad.mit.edu	37	chr17	33521249	33521249	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctggcagcgctggtaccaGcggaggctgggtggagcgga	6	5	21	9	3	0	0	0	0	0	0	0	3	0	3	1	8	4	5	1	8	1	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:33521249G>A	uc002hjd.2	-	1	164	c.78C>T	c.(76-78)CGC>CGT	p.R26R		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	26						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		GCTGGTACCAGCGGAGGCTGG	0.652													33	41					0	0	0	0	A	33521249	A	A	33521249	2	1	133	1	0	0	0	0	0	0	0	1	559	958	34	4		4	AMAC1	17	33521249	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	75729	33521249	47673961	142	23892											
RPL23	9349	broad.mit.edu	37	chr17	37008939	37008939	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcagcgggaagtctgttcagCcgtcccttgatccccttcac	6	10	10	15	2	3	1	2	1	1	0	5	2	5	2	4	1	2	2	4	1	1	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:37008939C>T	uc002hqx.1	-	3	234	c.144G>A	c.(142-144)CGG>CGA	p.R48R	RPL23_uc002hqw.1_5'UTR|RPL23_uc002hqy.1_Silent_p.R48R	NM_000978	NP_000969	P62829	RL23_HUMAN	ribosomal protein L23	48					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome				0						GTCTGTTCAGCCGTCCCTTGA	0.473													38	49					0	0	0	0	T	37008939	T	T	37008939	2	4	133	1	0	0	0	0	0	0	0	1	13635	726	26	4		4	RPL23	17	37008939	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	3487690	37008939	44186271	143	23893											
HEXIM1	10614	broad.mit.edu	37	chr17	43227082	43227082	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagctgacctgggaagagaaGaaaaagttcgacgagaaaca	19	4	12	6	2	0	4	0	1	0	3	1	8	0	5	1	1	2	2	1	1	6	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:43227082G>A	uc002iig.2	+	1	2399	c.525G>A	c.(523-525)AAG>AAA	p.K175K		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	175	Basic region; mediates nuclear localization and interaction with 7SK snRNA and NR3C1.				negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						GGGAAGAGAAGAAAAAGTTCG	0.547											OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	63					0	0	0	0	A	43227082	A	A	43227082	2	1	133	1	0	0	0	0	0	0	0	1	7115	933	33	2		2	HEXIM1	17	43227082	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	6218143	43227082	37968128	144	23894											
SNX11	29916	broad.mit.edu	37	chr17	46196402	46196402	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcctgcaaagccagctctcGgtgcctgagatagaagcctg	9	9	11	12	1	1	2	0	1	1	2	3	3	2	2	4	1	5	2	4	1	3	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr17:46196402G>A	uc002inf.1	+	7	747	c.393G>A	c.(391-393)TCG>TCA	p.S131S	SNX11_uc010wlg.1_Silent_p.S123S|SNX11_uc010wlh.1_Silent_p.S123S|SNX11_uc010wli.1_Silent_p.S70S|SNX11_uc010wlj.1_5'UTR|SNX11_uc002ing.1_Silent_p.S131S|SNX11_uc002inh.1_Silent_p.S131S	NM_152244	NP_689450	Q9Y5W9	SNX11_HUMAN	sorting nexin 11	131	PX.				cell communication|protein transport	membrane	phosphatidylinositol binding				0						GCCAGCTCTCGGTGCCTGAGA	0.532													15	116					0	0	0	0	A	46196402	A	A	46196402	2	1	133	1	0	0	0	0	0	0	0	1	14946	1103	39	1		1	SNX11	17	46196402	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	2969320	46196402	34998808	145	23895											
SLC39A6	25800	broad.mit.edu	37	chr18	33706965	33706965	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagattacagataacttcctCgccattgcgccttcctagaa	12	11	6	12	2	0	3	0	0	0	3	3	3	2	3	4	0	3	0	4	0	5	6			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr18:33706965C>T	uc010dmy.2	-	2	296	c.6G>A	c.(4-6)GCG>GCA	p.A2A	SLC39A6_uc002kzj.2_Intron|ELP2_uc002kzk.1_5'Flank|ELP2_uc010xcg.1_5'Flank|ELP2_uc002kzl.1_5'Flank|ELP2_uc002kzm.1_5'Flank|ELP2_uc010xch.1_5'Flank|ELP2_uc002kzn.1_5'Flank|ELP2_uc002kzo.1_5'Flank	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	2						integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						ATAACTTCCTCGCCATTGCGC	0.383													21	44					0	0	0	0	T	33706965	T	T	33706965	2	4	133	1	0	0	0	0	0	0	0	1	14686	871	31	1		1	SLC39A6	18	33706965	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08		33706965	44370283	146	23896											
RDH8	50700	broad.mit.edu	37	chr19	10127887	10127887	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atccagggagaagtggacgtGctgggtgagacttcacagcc	10	7	15	9	1	1	2	1	1	0	2	2	5	2	3	2	3	2	1	2	3	1	1			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:10127887G>A	uc002mmr.2	+	2	507	c.258G>A	c.(256-258)GTG>GTA	p.V86V		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	86	Helical; (Potential).				estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	AAGTGGACGTGCTGGGTGAGA	0.587													7	13					0	0	0	0	A	10127887	A	A	10127887	2	1	133	1	0	0	0	0	0	0	0	1	13261	1306	46	4		4	RDH8	19	10127887	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08		10127887	49001096	147	23897											
ZNF440	126070	broad.mit.edu	37	chr19	11942884	11942884	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcattcacgtgtccccgttAtgttcgtatacatgaaagga	11	12	9	9	3	1	1	1	1	0	0	3	2	2	2	2	1	2	4	2	1	4	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:11942884A>G	uc002msp.1	+	4	1049	c.893A>G	c.(892-894)TAT>TGT	p.Y298C		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	298	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTCCCCGTTATGTTCGTATA	0.398													21	60					0	0	0	0	G	11942884	G	G	11942884	3	3	133	1	0	0	0	0	1	0	0	0	17980	449	16	5	907	5	ZNF440	19	11942884	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	1814997	11942884	47186099	148	23898											
C19orf2	8725	broad.mit.edu	37	chr19	30496290	30496290	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaagaaaaacaatagatgaCttaaaaaaagtgatgaaaaa	25	7	7	2	0	0	5	0	3	0	2	0	5	0	5	0	0	1	1	0	0	11	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:30496290C>T	uc002nsr.2	+	5	420	c.390C>T	c.(388-390)GAC>GAT	p.D130D	C19orf2_uc002nsq.2_Silent_p.D112D|C19orf2_uc002nss.2_Silent_p.D90D|C19orf2_uc002nst.2_Silent_p.D54D	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	130					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		CAATAGATGACTTAAAAAAAG	0.299													5	16					0	0	0	0	T	30496290	T	T	30496290	2	4	133	1	0	0	0	0	0	0	0	1	1920	564	20	4		4	C19orf2	19	30496290	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	18553406	30496290	28632693	149	23899											
ZNF585A	199704	broad.mit.edu	37	chr19	37643886	37643886	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgacttggaaatgaaggaTttgccacagttactgcactc	11	12	10	8	0	0	2	0	2	0	0	1	4	0	4	1	2	3	2	1	2	3	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:37643886T>C	uc002ofo.1	-	5	1146	c.915A>G	c.(913-915)AAA>AAG	p.K305K	ZNF585A_uc002ofm.1_Silent_p.K250K|ZNF585A_uc002ofn.1_Silent_p.K250K	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	305	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAATGAAGGATTTGCCACAGT	0.418													92	142					0	0	0	0	C	37643886	C	C	37643886	2	2	133	1	0	0	0	0	0	0	0	1	18084	1490	52	5		5	ZNF585A	19	37643886	Silent	SNP	T	TCGA-CR-6491-01A-11D-1870-08	7147596	37643886	21485097	150	23900											
ZNF569	148266	broad.mit.edu	37	chr19	37903627	37903627	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagggtaagagatgagatttGagagaaggcttttccacatt	14	11	12	4	0	0	4	0	2	0	3	1	7	1	4	1	2	0	2	1	2	3	5			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:37903627G>C	uc002ogi.2	-	6	2491	c.1933C>G	c.(1933-1935)CAA>GAA	p.Q645E	ZNF569_uc002ogh.2_Missense_Mutation_p.Q486E|ZNF569_uc002ogj.2_Missense_Mutation_p.Q669E	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	645	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GATGAGATTTGAGAGAAGGCT	0.433													7	115					0	0	0	0	C	37903627	C	C	37903627	3	2	133	1	0	0	0	0	1	0	0	0	18067	1299	45	2	131	2	ZNF569	19	37903627	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	259741	37903627	21225356	151	23901											
IL28B	282617	broad.mit.edu	37	chr19	39735130	39735130	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccttcagcagaagcgacTcttcctagacagcaaaggca	13	7	9	12	1	2	2	1	0	1	2	4	3	4	2	2	1	3	3	2	1	3	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:39735130T>A	uc010xut.1	-	2	189	c.185A>T	c.(184-186)GAG>GTG	p.E62V	IL28B_uc010xuu.1_Missense_Mutation_p.E62V	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	62					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CAGAAGCGACTCTTCCTAGAC	0.617													3	12					0	0	0	0	A	39735130	A	A	39735130	3	1	133	1	0	0	0	0	1	0	0	0	7722	1551	54	5	420	5	IL28B	19	39735130	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	1831503	39735130	19393853	152	23902											
MAP3K10	4294	broad.mit.edu	37	chr19	40698536	40698536	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcacgtgctggtcaactggGctgtgcaggtggcccggggc	4	8	17	12	2	2	0	2	0	0	0	2	0	2	0	1	6	3	3	1	6	1	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:40698536G>A	uc002ona.2	+	1	886	c.598G>A	c.(598-600)GCT>ACT	p.A200T		NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	200	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						GGTCAACTGGGCTGTGCAGGT	0.622													14	15					0	0	0	0	A	40698536	A	A	40698536	3	1	133	1	0	0	0	0	1	0	0	0	9297	1203	42	4	600	4	MAP3K10	19	40698536	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	963406	40698536	18430447	153	23903											
ADCK4	79934	broad.mit.edu	37	chr19	41198104	41198105	+	Nonsense_Mutation	DNP	TG	AA	AA																															caggaaagcccctgccagctTgcggtgcagggcataggtct																										TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:41198104_41198105TG>AA	uc002oor.2	-	15	1772_1773	c.1470_1471CA>TT	c.(1468-1473)CGCAAG>CGTTAG	p.K491*	NUMBL_uc010xvq.1_5'Flank|NUMBL_uc002oon.2_5'Flank|NUMBL_uc002ooo.2_5'Flank|NUMBL_uc010xvr.1_5'Flank|ADCK4_uc002oop.1_Nonsense_Mutation_p.K168*|ADCK4_uc002ooq.1_Nonsense_Mutation_p.K450*	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	491						integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			CCTGCCAGCTTGCGGTGCAGGG	0.683													5	8					0	0	0	0	AA	41198105	AA	AA	41198104	4	1	133	1	0	0	0	0	0	1	0	0	290	1821	63	5	167	5	ADCK4	19	41198104	Nonsense_Mutation	DNP	TG	TCGA-CR-6491-01A-11D-1870-08	499568	41198104	17930879	154	23904											
DEDD2	162989	broad.mit.edu	37	chr19	42720875	42720875	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggtgcggcagcaggtcgtgGcgggccagcacgcgcaggag	7	3	20	11	5	0	0	0	0	0	0	1	1	0	1	1	6	3	4	1	6	0	0			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:42720875G>A	uc002osu.1	-	2	353	c.285C>T	c.(283-285)CGC>CGT	p.R95R	DEDD2_uc002osv.1_Intron|DEDD2_uc002osw.1_Silent_p.R95R|DEDD2_uc002osx.1_Intron|DEDD2_uc002osy.1_Silent_p.R95R	NM_133328	NP_579874	Q8WXF8	DEDD2_HUMAN	death effector domain-containing  DNA binding	95	DED.				activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity				0		Prostate(69;0.0704)				GCAGGTCGTGGCGGGCCAGCA	0.716													10	11					0	0	0	0	A	42720875	A	A	42720875	2	1	133	1	0	0	0	0	0	0	0	1	4402	1190	42	4		4	DEDD2	19	42720875	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	1522771	42720875	16408108	155	23905											
NAPA	8775	broad.mit.edu	37	chr19	47996260	47996260	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctgatactgctccagcagCgcagcgtaaccagccacctt	9	9	8	15	2	1	1	0	1	1	0	2	1	2	1	4	0	7	4	4	0	2	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:47996260C>T	uc002pha.1	-	7	819	c.519G>A	c.(517-519)GCG>GCA	p.A173A	uc002pgz.1_Intron|NAPA_uc002phb.1_Silent_p.A134A|NAPA_uc002phc.1_Silent_p.A60A|NAPA_uc002phd.1_Silent_p.A173A|NAPA_uc010elf.1_Silent_p.A67A	NM_003827	NP_003818	P54920	SNAA_HUMAN	N-ethylmaleimide-sensitive factor attachment	173					cellular membrane fusion|intra-Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport	cytosol					0		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000466)|all cancers(93;0.000739)|Epithelial(262;0.0168)|GBM - Glioblastoma multiforme(486;0.049)		GCTCCAGCAGCGCAGCGTAAC	0.642													7	87					0	0	0	0	T	47996260	T	T	47996260	2	4	133	1	0	0	0	0	0	0	0	1	10214	755	27	1		1	NAPA	19	47996260	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08	5275385	47996260	11132723	156	23906											
SIGLEC9	27180	broad.mit.edu	37	chr19	51628589	51628589	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgcggggagatacttctttCgtatggagaaaggaagtata	13	11	13	4	2	1	2	0	0	1	2	2	5	1	3	0	4	2	2	0	4	6	6	rs147625837		TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:51628589C>T	uc002pvu.2	+	1	425	c.358C>T	c.(358-360)CGT>TGT	p.R120C	SIGLEC9_uc010yct.1_Missense_Mutation_p.R120C	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	120	Extracellular (Potential).|Ig-like V-type.	Sialic acid (By similarity).		R->K: Loss of sialic acid binding.	cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ATACTTCTTTCGTATGGAGAA	0.498													24	64					0	0	0	0	T	51628589	T	T	51628589	3	4	133	1	0	0	0	0	1	0	0	0	14380	884	31	1	360	1	SIGLEC9	19	51628589	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08	3632329	51628589	7500394	157	23907											
ZNF530	348327	broad.mit.edu	37	chr19	58117075	58117075	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctggtgtggagcagtagAtgaggggacgccttctgcag	7	10	17	7	1	1	2	0	1	1	1	1	4	1	4	1	4	3	4	1	4	1	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr19:58117075A>G	uc002qpk.2	+	3	402	c.182A>G	c.(181-183)GAT>GGT	p.D61G	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGAGCAGTAGATGAGGGGACG	0.463													33	54					0	0	0	0	G	58117075	G	G	58117075	3	3	133	1	0	0	0	0	1	0	0	0	18038	333	12	5	192	5	ZNF530	19	58117075	Missense_Mutation	SNP	A	TCGA-CR-6491-01A-11D-1870-08	6488486	58117075	1011908	158	23908											
SLC23A2	9962	broad.mit.edu	37	chr20	4864369	4864369	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caattagggccaccgtgggtGtaatggtcaagggaccgatg	10	8	15	8	2	1	0	1	0	0	0	1	2	1	1	3	4	0	1	3	4	4	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr20:4864369G>A	uc002wlg.1	-	9	1118	c.743C>T	c.(742-744)ACA>ATA	p.T248I	SLC23A2_uc010zqr.1_Intron|SLC23A2_uc002wlh.1_Missense_Mutation_p.T248I|SLC23A2_uc002wli.2_Missense_Mutation_p.T247I	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	248	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						CACCGTGGGTGTAATGGTCAA	0.582													4	78					0	0	0	0	A	4864369	A	A	4864369	3	1	133	1	0	0	0	0	1	0	0	0	14527	1377	48	4	1245	4	SLC23A2	20	4864369	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08		4864369	58161151	159	23909											
GNAS	2778	broad.mit.edu	37	chr20	57428562	57428562	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacccaactttcaggtccTcaacccggcattcagggaag	11	7	9	14	1	3	1	3	0	0	1	4	2	4	2	3	3	2	1	3	3	3	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr20:57428562T>A	uc002xzw.2	+	1	527	c.242T>A	c.(241-243)CTC>CAC	p.L81H	GNASAS_uc002xzs.1_5'Flank|GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TTTCAGGTCCTCAACCCGGCA	0.612			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			3	22					0	0	0	0	A	57428562	A	A	57428562	3	1	133	1	0	0	0	0	1	0	0	0	6547	1551	54	5	986	5	GNAS	20	57428562	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	52564193	57428562	5596958	160	23910											
DSCAM	1826	broad.mit.edu	37	chr21	41385184	41385184	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggctccaggaccgtggggCgcttcagggtccggcttttc	3	10	16	12	3	1	0	1	0	0	0	4	1	3	1	3	6	0	3	3	6	0	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr21:41385184C>T	uc002yyq.1	-	33	6268	c.5816G>A	c.(5815-5817)CGC>CAC	p.R1939H	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1939	Cytoplasmic (Potential).			HRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQK SRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQR EGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV -> IGQVTSYICLHTLEWTFC (in Ref. 1; AAC17966).	cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GACCGTGGGGCGCTTCAGGGT	0.612													11	21					0	0	0	0	T	41385184	T	T	41385184	3	4	133	1	0	0	0	0	1	0	0	0	4790	768	27	1	226	1	DSCAM	21	41385184	Missense_Mutation	SNP	C	TCGA-CR-6491-01A-11D-1870-08		41385184	6744711	161	23911											
COL6A2	1292	broad.mit.edu	37	chr21	47532166	47532166	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcatcagctccttccgccGcggcaccttcaccgactgcg	5	7	11	18	5	2	0	2	0	0	0	4	1	4	0	5	2	2	3	5	2	0	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr21:47532166G>A	uc002zia.1	+	3	471	c.389G>A	c.(388-390)CGC>CAC	p.R130H	COL6A2_uc002zhy.1_Missense_Mutation_p.R130H|COL6A2_uc002zhz.1_Missense_Mutation_p.R130H|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	130	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		TCCTTCCGCCGCGGCACCTTC	0.672													18	28					0	0	0	0	A	47532166	A	A	47532166	3	1	133	1	0	0	0	0	1	0	0	0	3715	1087	38	1	395	1	COL6A2	21	47532166	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	6146982	47532166	597729	162	23912											
BCR	613	broad.mit.edu	37	chr22	23523321	23523321	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gagcgcttccgcatgatctaCctgcagacgttgctggccaa	8	9	11	13	3	1	2	0	1	1	1	2	3	2	2	3	1	4	5	3	1	2	3			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr22:23523321C>T	uc002zww.2	+	1	770	c.174C>T	c.(172-174)TAC>TAT	p.Y58Y	BCR_uc002zwx.2_Silent_p.Y58Y	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	58	Kinase.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12						GCATGATCTACCTGCAGACGT	0.677			T	ABL1| FGFR1|JAK2 	CML|ALL|AML								3	8					0	0	0	0	T	23523321	T	T	23523321	2	4	133	1	0	0	0	0	0	0	0	1	1390	518	18	4		4	BCR	22	23523321	Silent	SNP	C	TCGA-CR-6491-01A-11D-1870-08		23523321	27781245	163	23913											
TRMU	55687	broad.mit.edu	37	chr22	46748195	46748195	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctggtcactttatttccaTagaagacaataaggttctgg	12	13	8	8	0	2	2	1	0	1	2	3	2	3	2	2	3	0	1	2	3	5	6			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chr22:46748195T>C	uc003bhp.2	+	7	1104	c.740T>C	c.(739-741)ATA>ACA	p.I247T	TRMU_uc011arb.1_Missense_Mutation_p.I247T|TRMU_uc003bhq.2_Missense_Mutation_p.I29T|TRMU_uc003bhs.2_Missense_Mutation_p.I247T|TRMU_uc003bhr.2_Missense_Mutation_p.I133T|TRMU_uc003bht.2_Missense_Mutation_p.I100T|TRMU_uc003bhu.2_Missense_Mutation_p.I29T|TRMU_uc003bhv.2_Missense_Mutation_p.I100T	NM_018006	NP_060476	O75648	MTU1_HUMAN	tRNA 5-methylaminomethyl-2-thiouridylate	247						mitochondrion	ATP binding|sulfurtransferase activity|tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity|tRNA binding			ovary(1)	1		Ovarian(80;0.00965)|Breast(42;0.0194)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00449)|LUAD - Lung adenocarcinoma(64;0.248)		TTTATTTCCATAGAAGACAAT	0.502													85	133					0	0	0	0	C	46748195	C	C	46748195	3	2	133	1	0	0	0	0	1	0	0	0	16638	1406	49	5	766	5	TRMU	22	46748195	Missense_Mutation	SNP	T	TCGA-CR-6491-01A-11D-1870-08	23224874	46748195	4556371	164	23914											
ZMYM3	9203	broad.mit.edu	37	chrX	70463731	70463732	+	Missense_Mutation	DNP	CC	TA	TA																															tgtcaggttcatatcgttcaCcattgggccgagtgatttct																										TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chrX:70463731_70463732CC>TA	uc004dzh.1	-	21	3466_3467	c.3379_3380GG>TA	c.(3379-3381)GGT>TAT	p.G1127Y	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.G1127Y|ZMYM3_uc004dzj.1_Missense_Mutation_p.G1115Y	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1127					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					ATATCGTTCACCATTGGGCCGA	0.5													6	53					0	0	0	0	TA	70463732	TA	TA	70463731	3	4	133	1	0	0	0	0	1	0	0	0	17768	507	18	4	752	4	ZMYM3	23	70463731	Missense_Mutation	DNP	CC	TCGA-CR-6491-01A-11D-1870-08		70463731	84806829	165	23915											
THOC2	57187	broad.mit.edu	37	chrX	122765598	122765598	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctgcatcatggggtgtatGaaattcattacagagtacat	12	13	10	6	0	2	2	2	1	0	1	2	2	2	2	0	2	4	4	0	2	4	4			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chrX:122765598G>C	uc004etu.2	-	22	2454	c.2422C>G	c.(2422-2424)CAT>GAT	p.H808D	THOC2_uc011muh.1_Missense_Mutation_p.H733D	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	808					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TGGGGTGTATGAAATTCATTA	0.418													5	144					0	0	0	0	C	122765598	C	C	122765598	3	2	133	1	0	0	0	0	1	0	0	0	15931	1290	45	2	2427	2	THOC2	23	122765598	Missense_Mutation	SNP	G	TCGA-CR-6491-01A-11D-1870-08	52301867	122765598	32504962	166	23916											
TMEM187	8269	broad.mit.edu	37	chrX	153248203	153248203	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaggccacttctggtccaaGgtctgtgacgtgctccagtt	7	11	11	12	1	2	1	0	1	2	0	4	1	4	1	3	3	1	2	3	3	1	2			TCGA-CR-6491-01A-11D-1870-08	TCGA-CR-6491-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a32853ad-b6a3-4147-ae5a-f48fad71581e	a69cfaac-983d-43bd-87c4-1ae89072749e	g.chrX:153248203G>A	uc004fjq.2	+	2	1224	c.690G>A	c.(688-690)AAG>AAA	p.K230K	hsa-mir-3202-2|MI0014253_5'Flank	NM_003492	NP_003483	Q14656	TM187_HUMAN	transmembrane protein 187	230						integral to membrane|transport vesicle					0	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCTGGTCCAAGGTCTGTGACG	0.562													42	16					0	0	0	0	A	153248203	A	A	153248203	2	1	133	1	0	0	0	0	0	0	0	1	16175	991	35	4		4	TMEM187	23	153248203	Silent	SNP	G	TCGA-CR-6491-01A-11D-1870-08	30482605	153248203	2022357	167	23917											
SPEN	23013	broad.mit.edu	37	chr1	16260533	16260533	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actctgagatacaagcctcgGaggtgctggtagctgctgac	9	9	13	10	1	1	2	0	2	1	1	2	4	1	3	1	3	5	4	1	3	3	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:16260533G>A	uc001axk.1	+	11	8002	c.7798G>A	c.(7798-7800)GAG>AAG	p.E2600K	SPEN_uc010obp.1_Missense_Mutation_p.E2559K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2600	RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ACAAGCCTCGGAGGTGCTGGT	0.498													12	113					0	0	0	0	A	16260533	A	A	16260533	3	1	134	1	0	0	0	0	1	0	0	0	15104	1175	41	2	7840	2	SPEN	1	16260533	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08		16260533	232990088	1	23918											
CELSR2	1952	broad.mit.edu	37	chr1	109806318	109806318	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctcccaaccctggtacctCagcctcatgttccgcacgcg	7	9	7	18	3	3	0	2	0	1	0	5	0	4	0	5	1	3	3	5	1	2	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:109806318C>T	uc001dxa.3	+	9	4981	c.4920C>T	c.(4918-4920)CTC>CTT	p.L1640L		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1640	Extracellular (Potential).|Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCTGGTACCTCAGCCTCATGT	0.652											OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	120					0	0	0	0	T	109806318	T	T	109806318	2	4	134	1	0	0	0	0	0	0	0	1	3237	813	29	2		2	CELSR2	1	109806318	Silent	SNP	C	TCGA-CR-6492-01A-12D-2078-08	93545785	109806318	139444303	2	23919											
GPR89A	653519	broad.mit.edu	37	chr1	145765384	145765384	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttaccattatctgtgctaaTagcaggacaatgacattgga	13	12	8	8	0	1	1	0	1	1	0	1	3	1	3	1	2	3	2	1	2	5	5			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:145765384T>C	uc001eot.2	-	13	1320	c.1146A>G	c.(1144-1146)CTA>CTG	p.L382L	NBPF10_uc001emp.3_Intron|GPR89A_uc001eop.2_Silent_p.L80L|GPR89A_uc001eoq.2_RNA|GPR89A_uc001eor.2_Silent_p.L306L|GPR89A_uc010ozb.1_Silent_p.L357L|GPR89A_uc001eos.2_Silent_p.L262L|GPR89A_uc010ozc.1_Silent_p.L357L|GPR89A_uc010ozd.1_Silent_p.L329L|GPR89A_uc010oze.1_Silent_p.L382L	NM_001097612	NP_001091081	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A isoform 1	382	Helical; (Potential).				intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TCTGTGCTAATAGCAGGACAA	0.328													23	173					0	0	0	0	C	145765384	C	C	145765384	2	2	134	1	0	0	0	0	0	0	0	1	6756	1393	49	5		5	GPR89A	1	145765384	Silent	SNP	T	TCGA-CR-6492-01A-12D-2078-08	35959066	145765384	103485237	3	23920											
LHX9	56956	broad.mit.edu	37	chr1	197887087	197887087	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgcagatccaagactgaggCccgtctggccaaaggcgccc	9	4	13	15	3	1	3	0	1	1	2	2	3	2	3	4	3	0	1	4	3	2	0			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:197887087C>T	uc001guk.1	+	1	571	c.134C>T	c.(133-135)GCC>GTC	p.A45V	LHX9_uc009wzc.1_RNA|LHX9_uc001gui.1_Missense_Mutation_p.A36V|LHX9_uc001guj.1_Missense_Mutation_p.A51V	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	45					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						AAGACTGAGGCCCGTCTGGCC	0.657													7	79					0	0	0	0	T	197887087	T	T	197887087	3	4	134	1	0	0	0	0	1	0	0	0	8818	739	26	4	168	4	LHX9	1	197887087	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	52121703	197887087	51363534	4	23921											
PTPRC	5788	broad.mit.edu	37	chr1	198668699	198668699	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttcctaccttaggtgtttCatcagtacagacgcctcacc	8	13	6	14	1	3	1	3	0	0	1	4	1	4	1	4	1	2	2	4	1	3	5			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:198668699C>T	uc001gur.1	+	5	479	c.299C>T	c.(298-300)TCA>TTA	p.S100L	PTPRC_uc001gus.1_Missense_Mutation_p.S100L|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Missense_Mutation_p.S36L|PTPRC_uc009wzf.1_Missense_Mutation_p.S36L|PTPRC_uc010ppg.1_Missense_Mutation_p.S36L|PTPRC_uc001guu.1_Missense_Mutation_p.S143L|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	100	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TTAGGTGTTTCATCAGTACAG	0.488											OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	72					0	0	0	0	T	198668699	T	T	198668699	3	4	134	1	0	0	0	0	1	0	0	0	12862	838	29	2	324	2	PTPRC	1	198668699	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	781612	198668699	50581922	5	23922											
KIF14	9928	broad.mit.edu	37	chr1	200587425	200587425	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctcccacattcagtgtcaTtttgacagaatctatttcag	11	14	5	11	0	4	2	3	1	1	1	5	2	5	2	2	0	0	0	2	0	2	5			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:200587425T>C	uc010ppk.1	-	2	866	c.427A>G	c.(427-429)ATG>GTG	p.M143V	KIF14_uc010ppj.1_5'UTR	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	143	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TTCAGTGTCATTTTGACAGAA	0.348													5	58					0	0	0	0	C	200587425	C	C	200587425	3	2	134	1	0	0	0	0	1	0	0	0	8315	1493	52	5	4635	5	KIF14	1	200587425	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08	1918726	200587425	48663196	6	23923											
TTC13	79573	broad.mit.edu	37	chr1	231061288	231061288	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtattctcttgtttggcagGaaaccaggtgtttcatattg	8	17	10	6	0	2	0	1	0	1	0	3	1	2	1	1	3	1	4	1	3	3	7			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:231061288G>A	uc001huf.3	-	13	1594	c.1563C>T	c.(1561-1563)TTC>TTT	p.F521F	TTC13_uc009xfi.2_Silent_p.F468F|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Silent_p.F468F|TTC13_uc009xfk.1_Silent_p.F411F	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	521							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TGTTTGGCAGGAAACCAGGTG	0.408													6	62					0	0	0	0	A	231061288	A	A	231061288	2	1	134	1	0	0	0	0	0	0	0	1	16748	1165	41	2		2	TTC13	1	231061288	Silent	SNP	G	TCGA-CR-6492-01A-12D-2078-08	30473863	231061288	18189333	7	23924											
SH3BP5L	80851	broad.mit.edu	37	chr1	249108682	249108682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttcagcatctcctgccacGtggggtccagtcggttcttg	4	12	13	12	2	3	0	1	0	2	0	6	0	4	0	3	4	2	3	3	4	0	3	rs151290329		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr1:249108682G>A	uc001iew.1	-	5	1055	c.503C>T	c.(502-504)ACG>ATG	p.T168M	SH3BP5L_uc010pzp.1_Missense_Mutation_p.T61M|SH3BP5L_uc010pzq.1_Missense_Mutation_p.T136M|SH3BP5L_uc001iev.1_Missense_Mutation_p.T49M	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	168											0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CTCCTGCCACGTGGGGTCCAG	0.592													3	41					0	0	0	0	A	249108682	A	A	249108682	3	1	134	1	0	0	0	0	1	0	0	0	14313	1145	40	1	690	1	SH3BP5L	1	249108682	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	18047394	249108682	141939	8	23925											
KLF11	8462	broad.mit.edu	37	chr2	10186310	10186310	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acatatgtgagtccatcctgGagaggaagcggcatgacagc	12	7	13	9	1	0	3	0	2	0	1	2	5	2	4	2	3	2	1	2	3	2	1			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr2:10186310G>A	uc002raf.1	+	2	238	c.76G>A	c.(76-78)GAG>AAG	p.E26K	KLF11_uc010yjc.1_Missense_Mutation_p.E9K	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	26					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GTCCATCCTGGAGAGGAAGCG	0.522													5	50					0	0	0	0	A	10186310	A	A	10186310	3	1	134	1	0	0	0	0	1	0	0	0	8378	1175	41	2	82	2	KLF11	2	10186310	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08		10186310	233013063	9	23926											
PSD4	23550	broad.mit.edu	37	chr2	113950906	113950906	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcctctaccagttctccaGacgcttccaccattgcaatc	10	11	4	16	1	2	1	0	0	2	1	6	1	4	1	5	0	2	3	5	0	3	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr2:113950906G>T	uc002tjc.2	+	8	2174	c.1991G>T	c.(1990-1992)AGA>ATA	p.R664I	PSD4_uc002tjd.2_Missense_Mutation_p.R285I|PSD4_uc002tje.2_Missense_Mutation_p.R635I|PSD4_uc002tjf.2_Missense_Mutation_p.R285I	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	664	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CAGTTCTCCAGACGCTTCCAC	0.597													4	62					0.00024832	0.000269913	1	0	T	113950906	T	T	113950906	3	4	134	1	0	0	0	0	1	0	0	0	12711	942	33	2	2017	2	PSD4	2	113950906	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	103764596	113950906	129248467	10	23927											
BMPR2	659	broad.mit.edu	37	chr2	203420620	203420620	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctactcagatctatccTctccccaagcagcagaacct	10	9	5	17	0	3	2	1	0	2	2	5	2	4	2	5	0	5	2	5	0	4	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr2:203420620T>G	uc002uzf.3	+	12	3380	c.2232T>G	c.(2230-2232)CCT>CCG	p.P744P	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	744	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						AGATCTATCCTCTCCCCAAGC	0.458													5	72					0	0	0	0	G	203420620	G	G	203420620	2	3	134	1	0	0	0	0	0	0	0	1	1474	1538	54	5		5	BMPR2	2	203420620	Silent	SNP	T	TCGA-CR-6492-01A-12D-2078-08	89469714	203420620	39778753	11	23928											
CHL1	10752	broad.mit.edu	37	chr3	369921	369921	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aattccatcgaacaattcagGaacattcaggatcccaaacg	16	8	6	11	2	2	0	2	0	0	0	5	3	4	2	2	2	3	0	2	2	5	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:369921G>A	uc003bou.2	+	5	540	c.269G>A	c.(268-270)GGA>GAA	p.G90E	CHL1_uc003bot.2_Missense_Mutation_p.G90E|CHL1_uc003bow.1_Missense_Mutation_p.G90E|CHL1_uc011asi.1_Missense_Mutation_p.G90E	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	90	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AACAATTCAGGAACATTCAGG	0.388													6	94					0	0	0	0	A	369921	A	A	369921	3	1	134	1	0	0	0	0	1	0	0	0	3364	1174	41	2	279	2	CHL1	3	369921	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08		369921	197652509	12	23929											
CRYBG3	131544	broad.mit.edu	37	chr3	97598838	97598838	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtgttgcagatggttatcTatgatctccatgaaagtaca	11	14	9	7	0	2	3	0	2	2	1	3	3	2	3	1	1	2	4	1	1	4	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:97598838T>A	uc003drx.2	+	3	1118	c.1054T>A	c.(1054-1056)TAT>AAT	p.Y352N		NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						GATGGTTATCTATGATCTCCA	0.284													10	59					0	0	0	0	A	97598838	A	A	97598838	3	1	134	1	0	0	0	0	1	0	0	0	3928	1522	53	5	1064	5	CRYBG3	3	97598838	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08	97228917	97598838	100423592	13	23930											
CLSTN2	64084	broad.mit.edu	37	chr3	140277533	140277533	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgaggtagatgcctatgtGatggtcctccaggccatcga	8	10	12	11	1	0	3	0	2	0	1	3	4	2	3	5	3	1	1	5	3	2	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:140277533G>C	uc003etn.2	+	12	2065	c.1875G>C	c.(1873-1875)GTG>GTC	p.V625V		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	625	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						ATGCCTATGTGATGGTCCTCC	0.547										HNSCC(16;0.037)			5	65					0	0	0	0	C	140277533	C	C	140277533	2	2	134	1	0	0	0	0	0	0	0	1	3577	1277	45	2		2	CLSTN2	3	140277533	Silent	SNP	G	TCGA-CR-6492-01A-12D-2078-08	42678695	140277533	57744897	14	23931											
PHC3	80012	broad.mit.edu	37	chr3	169835109	169835109	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtggaggtttgttctctaTactgggaatgctactgtgca	7	15	12	7	0	1	0	0	0	1	0	2	2	1	2	0	3	4	4	0	3	4	5			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:169835109T>C	uc010hws.1	-	10	2126	c.2062A>G	c.(2062-2064)ATA>GTA	p.I688V	PHC3_uc003fgl.2_Missense_Mutation_p.I700V|PHC3_uc011bpq.1_Missense_Mutation_p.I647V	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	polyhomeotic like 3	688					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTGTTCTCTATACTGGGAATG	0.448													7	42					0	0	0	0	C	169835109	C	C	169835109	3	2	134	1	0	0	0	0	1	0	0	0	11873	1406	49	5	913	5	PHC3	3	169835109	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08	29557576	169835109	28187321	15	23932											
EIF4G1	1981	broad.mit.edu	37	chr3	184045767	184045767	+	Frame_Shift_Del	DEL	G	-	-																															ctgctctgtgctgggcatctGtctactgctcagtactacca																										TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:184045767delG	uc003fnp.2	+	26	4128	c.3930delG	c.(3928-3930)CTGfs	p.L1310fs	EIF4G1_uc003fnt.2_Frame_Shift_Del_p.L1021fs|EIF4G1_uc003fnq.2_Frame_Shift_Del_p.L1223fs|EIF4G1_uc003fnr.2_Frame_Shift_Del_p.L1146fs|EIF4G1_uc010hxx.2_Frame_Shift_Del_p.L1317fs|EIF4G1_uc003fns.2_Frame_Shift_Del_p.L1270fs|EIF4G1_uc010hxy.2_Frame_Shift_Del_p.L1317fs|EIF4G1_uc003fnv.3_Frame_Shift_Del_p.L1311fs|EIF4G1_uc003fnu.3_Frame_Shift_Del_p.L1310fs|EIF4G1_uc003fnw.2_Frame_Shift_Del_p.L1317fs|EIF4G1_uc003fnx.2_Frame_Shift_Del_p.L1115fs|EIF4G1_uc003fny.3_Frame_Shift_Del_p.L1114fs|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1310	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTGGGCATCTGTCTACTGCTC	0.537													---	---	---								-	184045767	-	-	184045767	7	5	134	1	0	1	0	1	0	0	0	0	5060	1364	48	0	4024	0	EIF4G1	3	184045767	Frame_Shift_Del	DEL	G	TCGA-CR-6492-01A-12D-2078-08	14210658	184045767	13976663	16	23933											
TP63	8626	broad.mit.edu	37	chr3	189526137	189526137	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcctcgtccaccagtccctAtaacacagaccacgcgcaga	11	6	6	18	3	0	2	0	0	0	2	4	2	3	2	5	0	1	1	5	0	2	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr3:189526137A>G	uc003fry.2	+	4	490	c.401A>G	c.(400-402)TAT>TGT	p.Y134C	TP63_uc003frx.2_Missense_Mutation_p.Y134C|TP63_uc003frz.2_Missense_Mutation_p.Y134C|TP63_uc010hzc.1_Missense_Mutation_p.Y134C|TP63_uc003fsa.2_Missense_Mutation_p.Y40C|TP63_uc003fsb.2_Missense_Mutation_p.Y40C|TP63_uc003fsc.2_Missense_Mutation_p.Y40C|TP63_uc003fsd.2_Missense_Mutation_p.Y40C|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_Missense_Mutation_p.Y15C	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	134					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACCAGTCCCTATAACACAGAC	0.617									Hay-Wells_syndrome	HNSCC(45;0.13)			15	80					0	0	0	0	G	189526137	G	G	189526137	3	3	134	1	0	0	0	0	1	0	0	0	16459	449	16	5	461	5	TP63	3	189526137	Missense_Mutation	SNP	A	TCGA-CR-6492-01A-12D-2078-08	5480370	189526137	8496293	17	23934											
EVC	2121	broad.mit.edu	37	chr4	5750014	5750014	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgaagggctattgtgcgattCtcaggagctgcaggctctgg	7	10	15	9	2	2	0	1	0	2	0	3	3	2	1	0	4	3	4	0	4	2	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:5750014C>T	uc003gil.1	+	8	1263	c.1079C>T	c.(1078-1080)TCT>TTT	p.S360F	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Silent_p.E463E	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	360					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				TTGTGCGATTCTCAGGAGCTG	0.488													3	36					0	0	0	0	T	5750014	T	T	5750014	3	4	134	1	0	0	0	0	1	0	0	0	5309	913	32	2	1109	2	EVC	4	5750014	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08		5750014	185404262	18	23935											
FAT1	2195	broad.mit.edu	37	chr4	187530345	187530345	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttttcacttaccgtttctcGgtcgagaagtttggtcactt	6	18	8	9	3	3	1	2	0	1	1	5	2	3	1	1	2	1	2	1	2	2	6			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:187530345G>A	uc003izf.2	-	16	10386	c.10198C>T	c.(10198-10200)CGA>TGA	p.R3400*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3400	Extracellular (Potential).|Cadherin 31.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACCGTTTCTCGGTCGAGAAGT	0.453										HNSCC(5;0.00058)			8	33					0	0	0	0	A	187530345	A	A	187530345	4	1	134	1	0	0	0	0	0	1	0	0	5721	1124	39	1	3616	1	FAT1	4	187530345	Nonsense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	181780331	187530345	3623931	19	23936											
FAT1	2195	broad.mit.edu	37	chr4	187542660	187542660	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatacaccactgatgattGactatgggctgtaaccatcc	11	12	7	11	0	1	3	1	3	0	0	2	3	2	3	3	1	2	2	3	1	3	5			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:187542660G>A	uc003izf.2	-	10	5268	c.5080C>T	c.(5080-5082)CAA>TAA	p.Q1694*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1694	Extracellular (Potential).|Cadherin 15.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACTGATGATTGACTATGGGCT	0.393										HNSCC(5;0.00058)			7	49					0	0	0	0	A	187542660	A	A	187542660	4	1	134	1	0	0	0	0	0	1	0	0	5721	1299	45	2	8758	2	FAT1	4	187542660	Nonsense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	12315	187542660	3611616	20	23937											
TRIML2	205860	broad.mit.edu	37	chr4	189022315	189022315	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatgcattcctgctgtctCtggagattctgctcacactc	7	14	8	12	0	3	1	1	0	2	1	6	3	4	1	1	1	3	3	1	1	1	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr4:189022315C>G	uc003izl.2	-	3	261	c.225G>C	c.(223-225)CAG>CAC	p.Q75H	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Missense_Mutation_p.Q125H|TRIML2_uc011clf.1_Missense_Mutation_p.Q125H	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	75	Potential.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		CCTGCTGTCTCTGGAGATTCT	0.428													5	45					0	0	0	0	G	189022315	G	G	189022315	3	3	134	1	0	0	0	0	1	0	0	0	16618	912	32	2	958	2	TRIML2	4	189022315	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	1479655	189022315	2131961	21	23938											
PLEKHG4B	153478	broad.mit.edu	37	chr5	171485	171485	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgggcgagctccgagccGccgaggtcgtggtctgcttc	4	8	16	13	5	1	0	0	0	1	0	4	3	2	0	3	3	4	3	3	3	0	1			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:171485G>A	uc003jak.2	+	14	2958	c.2908G>A	c.(2908-2910)GCC>ACC	p.A970T		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	970	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GCTCCGAGCCGCCGAGGTCGT	0.677													4	28					0	0	0	0	A	171485	A	A	171485	3	1	134	1	0	0	0	0	1	0	0	0	12127	1087	38	1	2962	1	PLEKHG4B	5	171485	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08		171485	180743775	22	23939											
ADCY2	108	broad.mit.edu	37	chr5	7626401	7626401	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taattgcatcaagtcgcggaTcaagttggaatttgaaaaac	15	11	9	6	2	2	1	2	1	0	0	3	3	2	3	0	2	2	2	0	2	6	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:7626401T>C	uc003jdz.1	+	4	759	c.692T>C	c.(691-693)ATC>ACC	p.I231T		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	231	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AAGTCGCGGATCAAGTTGGAA	0.398													3	56					0	0	0	0	C	7626401	C	C	7626401	3	2	134	1	0	0	0	0	1	0	0	0	294	1435	50	5	706	5	ADCY2	5	7626401	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08	7454916	7626401	173288859	23	23940											
PIK3R1	5295	broad.mit.edu	37	chr5	67589628	67589628	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaaaagtcgagaatatgAtagattatatgaagaatata	22	10	8	1	1	0	6	0	2	0	4	1	7	0	6	0	0	0	0	0	0	12	6			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:67589628A>T	uc003jva.2	+	11	1951	c.1391A>T	c.(1390-1392)GAT>GTT	p.D464V	PIK3R1_uc003jvb.2_Missense_Mutation_p.D464V|PIK3R1_uc003jvc.2_Missense_Mutation_p.D164V|PIK3R1_uc003jvd.2_Missense_Mutation_p.D194V|PIK3R1_uc003jve.2_Missense_Mutation_p.D143V|PIK3R1_uc011crb.1_Missense_Mutation_p.D134V	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	464					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.D464fs*2(1)|p.?(1)|p.D464H(1)|p.Y463_L466del(1)|p.T454_D464del(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CGAGAATATGATAGATTATAT	0.294			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			9	54					0	0	0	0	T	67589628	T	T	67589628	3	4	134	1	0	0	0	0	1	0	0	0	11973	333	12	5	1559	5	PIK3R1	5	67589628	Missense_Mutation	SNP	A	TCGA-CR-6492-01A-12D-2078-08	59963227	67589628	113325632	24	23941											
HAPLN1	1404	broad.mit.edu	37	chr5	82948498	82948498	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggtaatccgaagttagcttGgtccacttaattcggatttt	10	15	9	7	2	0	0	0	0	0	0	3	2	2	1	2	3	1	3	2	3	4	7			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:82948498G>T	uc003kim.2	-	2	317	c.246C>A	c.(244-246)ACC>ACA	p.T82T	HAPLN1_uc003kin.2_Silent_p.T82T	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	82	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		AAGTTAGCTTGGTCCACTTAA	0.423													5	97					1.6384e-10	1.8409e-10	1	0	T	82948498	T	T	82948498	2	4	134	1	0	0	0	0	0	0	0	1	6993	1335	47	4		4	HAPLN1	5	82948498	Silent	SNP	G	TCGA-CR-6492-01A-12D-2078-08	15358870	82948498	97966762	25	23942											
RASA1	5921	broad.mit.edu	37	chr5	86659189	86659189	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggaaaacgttggaaaaattTatattttatcttagagggta	16	14	9	2	1	1	1	0	0	1	1	1	3	1	3	0	3	1	2	0	3	9	8			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:86659189T>A	uc003kiw.2	+	11	1596	c.1478T>A	c.(1477-1479)TTA>TAA	p.L493*	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Nonsense_Mutation_p.L316*|RASA1_uc011ctv.1_Nonsense_Mutation_p.L326*|RASA1_uc011ctw.1_Nonsense_Mutation_p.L327*|RASA1_uc010jaw.2_Nonsense_Mutation_p.L315*	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	493	PH.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TGGAAAAATTTATATTTTATC	0.289													10	33					0	0	0	0	A	86659189	A	A	86659189	4	1	134	1	0	0	0	0	0	1	0	0	13125	1764	61	5	1532	5	RASA1	5	86659189	Nonsense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08	3710691	86659189	94256071	26	23943											
AQPEP	206338	broad.mit.edu	37	chr5	115327924	115327924	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccaaaagatcaactgacaGaaaaaaagactctgatctcc	20	6	5	10	0	3	5	1	2	2	3	4	5	3	5	2	0	2	0	2	0	7	0			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:115327924G>A	uc003kro.2	+	5	1374	c.1210G>A	c.(1210-1212)GAA>AAA	p.E404K	AQPEP_uc003krp.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	404	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TCAACTGACAGAAAAAAAGAC	0.388													5	84					0	0	0	0	A	115327924	A	A	115327924	3	1	134	1	0	0	0	0	1	0	0	0	834	943	33	2	1228	2	AQPEP	5	115327924	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	28668735	115327924	65587336	27	23944											
PCDHA7	56141	broad.mit.edu	37	chr5	140214357	140214357	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggacattaacgacaaccCtccggtgttcccagcgacac	12	6	9	14	3	0	0	0	0	0	0	2	4	2	1	3	2	3	1	3	2	3	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:140214357C>G	uc003lhq.2	+	1	389	c.389C>G	c.(388-390)CCT>CGT	p.P130R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.P130R	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	130	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGACAACCCTCCGGTGTTC	0.592													8	184					0	0	0	0	G	140214357	G	G	140214357	3	3	134	1	0	0	0	0	1	0	0	0	11583	681	24	4	391	4	PCDHA7	5	140214357	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	24886433	140214357	40700903	28	23945											
KIF4B	285643	broad.mit.edu	37	chr5	154393632	154393632	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcaataaagcagtagcgccGctcataaaaggcatatttaa	16	10	7	8	2	2	0	2	0	0	0	2	0	2	0	1	1	2	4	1	1	8	7			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr5:154393632G>A	uc010jih.1	+	1	373	c.213G>A	c.(211-213)CCG>CCA	p.P71P		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	71	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CAGTAGCGCCGCTCATAAAAG	0.463													9	62					0	0	0	0	A	154393632	A	A	154393632	2	1	134	1	0	0	0	0	0	0	0	1	8343	1074	38	1		1	KIF4B	5	154393632	Silent	SNP	G	TCGA-CR-6492-01A-12D-2078-08	14179275	154393632	26521628	29	23946											
ALDH5A1	7915	broad.mit.edu	37	chr6	24523069	24523069	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaaagcattcgccgaggcCatgaagaagaacctgcgcgt	13	6	12	10	4	0	3	0	1	0	2	1	4	0	3	3	1	3	2	3	1	5	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:24523069C>T	uc003neg.2	+	7	1117	c.1089C>T	c.(1087-1089)GCC>GCT	p.A363A	ALDH5A1_uc003nef.2_Silent_p.A376A	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	363					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	TCGCCGAGGCCATGAAGAAGA	0.428													10	106					0	0	0	0	T	24523069	T	T	24523069	2	4	134	1	0	0	0	0	0	0	0	1	502	581	21	4		4	ALDH5A1	6	24523069	Silent	SNP	C	TCGA-CR-6492-01A-12D-2078-08		24523069	146591998	30	23947											
ZNF391	346157	broad.mit.edu	37	chr6	27368887	27368887	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacgaatacacactggagaGaatccctatgaatgcagtaa	17	7	8	9	1	0	2	0	1	0	1	1	5	1	3	1	1	3	2	1	1	7	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:27368887G>C	uc003njf.1	+	3	1256	c.738G>C	c.(736-738)GAG>GAC	p.E246D		NM_001076781	NP_001070249	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(2)|skin(1)	3						ACACTGGAGAGAATCCCTATG	0.433													3	44					0	0	0	0	C	27368887	C	C	27368887	3	2	134	1	0	0	0	0	1	0	0	0	17946	933	33	2	740	2	ZNF391	6	27368887	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	2845818	27368887	143746180	31	23948											
ZKSCAN3	80317	broad.mit.edu	37	chr6	28327420	28327420	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccagtctacagaagaccaGatggagcttctggtcataaa	13	8	10	10	0	3	3	1	0	2	3	3	4	3	4	2	2	2	1	2	2	4	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:28327420G>A	uc003nle.3	+	2	273	c.57G>A	c.(55-57)CAG>CAA	p.Q19Q	ZKSCAN3_uc010jrc.2_Silent_p.Q19Q|ZKSCAN3_uc003nlf.3_Intron	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	19					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						CAGAAGACCAGATGGAGCTTC	0.562													9	98					0	0	0	0	A	28327420	A	A	28327420	2	1	134	1	0	0	0	0	0	0	0	1	17755	933	33	2		2	ZKSCAN3	6	28327420	Silent	SNP	G	TCGA-CR-6492-01A-12D-2078-08	958533	28327420	142787647	32	23949											
DLK2	65989	broad.mit.edu	37	chr6	43418618	43418618	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccccgtggcaggtaccaCtacagctgaggtgggcccta	7	7	14	13	1	0	1	0	1	0	0	0	1	0	1	4	5	3	3	4	5	3	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:43418618C>G	uc003ova.2	-	6	1020	c.811G>C	c.(811-813)GTG>CTG	p.V271L	DLK2_uc003ovb.2_Missense_Mutation_p.V271L	NM_023932	NP_076421	Q6UY11	DLK2_HUMAN	EGF-like-domain, multiple 9 precursor	271	Extracellular (Potential).					integral to membrane	calcium ion binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GCAGGTACCACTACAGCTGAG	0.647													6	63					0	0	0	0	G	43418618	G	G	43418618	3	3	134	1	0	0	0	0	1	0	0	0	4587	565	20	4	344	4	DLK2	6	43418618	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	15091198	43418618	127696449	33	23950											
PRDM1	639	broad.mit.edu	37	chr6	106553695	106553695	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaatctcattaaaaacaaaAgaaacatgaccggctacaag	20	7	6	8	1	1	3	1	2	1	1	2	3	1	3	1	1	3	1	1	1	9	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:106553695A>G	uc003prd.2	+	5	1894	c.1660A>G	c.(1660-1662)AGA>GGA	p.R554G	PRDM1_uc003pre.2_Missense_Mutation_p.R420G	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	554					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		TAAAAACAAAAGAAACATGAC	0.537			D|N|Mis|F|S		DLBCL								4	50					0	0	0	0	G	106553695	G	G	106553695	3	3	134	1	0	0	0	0	1	0	0	0	12512	64	3	5	1691	5	PRDM1	6	106553695	Missense_Mutation	SNP	A	TCGA-CR-6492-01A-12D-2078-08	63135077	106553695	64561372	34	23951											
C6orf170	221322	broad.mit.edu	37	chr6	121600334	121600334	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccttcttctacagatgcaaTtcttgccaaaataccagcta	12	12	4	13	0	3	1	0	0	3	1	3	1	3	1	3	0	5	2	3	0	6	7			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:121600334T>C	uc003pyo.1	-	15	1734	c.1666A>G	c.(1666-1668)ATT>GTT	p.I556V	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_Missense_Mutation_p.I75V	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	556					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		ACAGATGCAATTCTTGCCAAA	0.328													5	59					0	0	0	0	C	121600334	C	C	121600334	3	2	134	1	0	0	0	0	1	0	0	0	2354	1493	52	5	2179	5	C6orf170	6	121600334	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08	15046639	121600334	49514733	35	23952											
SYNE1	23345	broad.mit.edu	37	chr6	152722368	152722368	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttgttatgtcattaataaActtctccacttgtgtacttt	9	20	5	7	0	2	0	1	0	1	0	3	0	2	0	1	0	2	3	1	0	5	8	rs138004884	byFrequency	TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr6:152722368A>G	uc010kiw.2	-	47	7536	c.6934T>C	c.(6934-6936)TTT>CTT	p.F2312L	SYNE1_uc003qot.3_Missense_Mutation_p.F2319L|SYNE1_uc003qou.3_Missense_Mutation_p.F2312L|SYNE1_uc010kjb.1_Missense_Mutation_p.F2295L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2312	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCATTAATAAACTTCTCCACT	0.393										HNSCC(10;0.0054)			4	66					0	0	0	0	G	152722368	G	G	152722368	3	3	134	1	0	0	0	0	1	0	0	0	15511	43	2	5	19932	5	SYNE1	6	152722368	Missense_Mutation	SNP	A	TCGA-CR-6492-01A-12D-2078-08	31122034	152722368	18392699	36	23953											
NPSR1	387129	broad.mit.edu	37	chr7	34888178	34888178	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagacacccaggagcgtttcTatgcctctgtgatcattcag	9	11	9	12	1	4	2	2	1	2	1	4	3	4	3	2	1	2	1	2	1	1	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr7:34888178T>C	uc003teg.1	+	8	1056	c.928T>C	c.(928-930)TAT>CAT	p.Y310H	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Missense_Mutation_p.Y310H|NPSR1_uc010kwt.1_Missense_Mutation_p.Y157H|NPSR1_uc010kwu.1_Missense_Mutation_p.Y100H|NPSR1_uc010kwv.1_Missense_Mutation_p.Y244H|NPSR1_uc003tei.1_Missense_Mutation_p.Y310H|NPSR1_uc010kww.1_Missense_Mutation_p.Y299H|NPSR1_uc011kar.1_Missense_Mutation_p.Y244H	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	310	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	GGAGCGTTTCTATGCCTCTGT	0.498													11	203					0	0	0	0	C	34888178	C	C	34888178	3	2	134	1	0	0	0	0	1	0	0	0	10654	1522	53	5	958	5	NPSR1	7	34888178	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08		34888178	124250485	37	23954											
TRIM24	8805	broad.mit.edu	37	chr7	138269634	138269634	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttagtgatgattcagatgatGactttgtacagccccggaag	11	12	11	7	1	1	5	1	4	0	1	1	6	1	6	2	1	2	1	2	1	3	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr7:138269634G>A	uc003vuc.2	+	19	3306	c.3091G>A	c.(3091-3093)GAC>AAC	p.D1031N	TRIM24_uc003vub.2_Missense_Mutation_p.D997N	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	1031					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						TTCAGATGATGACTTTGTACA	0.373													4	46					0	0	0	0	A	138269634	A	A	138269634	3	1	134	1	0	0	0	0	1	0	0	0	16565	1290	45	2	3165	2	TRIM24	7	138269634	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	103381456	138269634	20869029	38	23955											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	11					0	0	0	0	A	21971120	A	A	21971120	4	1	134	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08		21971120	119242311	39	23956											
TOPORS	10210	broad.mit.edu	37	chr9	32542338	32542338	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagactgtctagaataatGagctctggacagagtcctcc	12	10	10	9	0	2	5	0	2	2	3	4	6	4	6	2	1	1	1	2	1	4	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr9:32542338G>A	uc003zrb.2	-	3	2352	c.2185C>T	c.(2185-2187)CAT>TAT	p.H729Y	TOPORS_uc003zrc.2_Missense_Mutation_p.H662Y	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	729	Interaction with TOP1.|Arg-rich.|Interaction with p53/TP53.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CTAGAATAATGAGCTCTGGAC	0.378													10	154					0	0	0	0	A	32542338	A	A	32542338	3	1	134	1	0	0	0	0	1	0	0	0	16437	1290	45	2	956	2	TOPORS	9	32542338	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	10571218	32542338	108671093	40	23957											
ABCA2	20	broad.mit.edu	37	chr9	139906446	139906446	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccacgatgatgaagatggcGatgacgacatccgtgccctg	10	7	13	11	4	0	4	0	3	0	1	1	7	1	4	3	1	1	0	3	1	1	0			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr9:139906446G>A	uc011mem.1	-	34	5530	c.5382C>T	c.(5380-5382)ATC>ATT	p.I1794I	ABCA2_uc011mel.1_Silent_p.I1795I|ABCA2_uc004ckl.1_Silent_p.I1725I|ABCA2_uc004ckm.1_Silent_p.I1825I	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1794	Helical; (Potential).				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGAAGATGGCGATGACGACAT	0.637													4	48					0	0	0	0	A	139906446	A	A	139906446	2	1	134	1	0	0	0	0	0	0	0	1	32	1048	37	1		1	ABCA2	9	139906446	Silent	SNP	G	TCGA-CR-6492-01A-12D-2078-08	107364108	139906446	1306985	41	23958											
DNMBP	23268	broad.mit.edu	37	chr10	101657950	101657950	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtgggattctggggtggaaTtcagcaactccattagcaac	10	10	13	8	0	2	0	1	0	1	0	3	2	3	2	1	5	4	2	1	5	4	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr10:101657950T>A	uc001kqj.2	-	9	2905	c.2813A>T	c.(2812-2814)AAT>ATT	p.N938I	DNMBP_uc010qpl.1_5'UTR|DNMBP_uc001kqg.2_Missense_Mutation_p.N226I|DNMBP_uc001kqh.2_Missense_Mutation_p.N570I	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	938	DH.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TGGGGTGGAATTCAGCAACTC	0.438													11	73					0	0	0	0	A	101657950	A	A	101657950	3	1	134	1	0	0	0	0	1	0	0	0	4696	1493	52	5	1956	5	DNMBP	10	101657950	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08		101657950	33876797	42	23959											
TTC17	55761	broad.mit.edu	37	chr11	43513699	43513699	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacttcactctgggcaatGtctacgtggcaatggtgaga	10	10	11	10	1	3	1	1	1	2	1	3	2	3	1	1	3	1	2	1	3	3	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:43513699G>T	uc001mxi.2	+	23	3294	c.3280G>T	c.(3280-3282)GTC>TTC	p.V1094F	TTC17_uc010rfj.1_Missense_Mutation_p.V1094F|TTC17_uc001mxl.2_Missense_Mutation_p.V150F|TTC17_uc001mxm.2_Missense_Mutation_p.V75F	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	1094	TPR 6.						binding			ovary(5)	5						TCTGGGCAATGTCTACGTGGC	0.478													9	86					1.12685e-05	1.2383e-05	1	0	T	43513699	T	T	43513699	3	4	134	1	0	0	0	0	1	0	0	0	16752	1377	48	4	3370	4	TTC17	11	43513699	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08		43513699	91492817	43	23960											
OR5B12	390191	broad.mit.edu	37	chr11	58207492	58207492	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagtccagtagaatcaattCaatcatccccaggttcccaa	13	9	7	12	0	3	1	3	0	0	1	6	2	6	2	4	2	0	2	4	2	5	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:58207492C>G	uc010rkh.1	-	1	133	c.133G>C	c.(133-135)GAA>CAA	p.E45Q		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	45	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGAATCAATTCAATCATCCCC	0.488													5	49					0	0	0	0	G	58207492	G	G	58207492	3	3	134	1	0	0	0	0	1	0	0	0	11202	835	29	2	815	2	OR5B12	11	58207492	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	14693793	58207492	76799024	44	23961											
SNX15	29907	broad.mit.edu	37	chr11	64802351	64802351	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcagtgatcgaggagcggCgaaagggggcagaggacctg	10	4	18	9	3	1	2	1	1	0	1	2	6	1	4	2	5	1	1	2	5	1	0			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:64802351C>T	uc001oci.3	+	7	942	c.289C>T	c.(289-291)CGA>TGA	p.R97*	SNX15_uc009ypy.2_Nonsense_Mutation_p.R97*|SNX15_uc001ocj.2_Nonsense_Mutation_p.R97*|SNX15_uc001ock.2_Nonsense_Mutation_p.R97*	NM_013306	NP_037438	Q9NRS6	SNX15_HUMAN	sorting nexin 15 isoform A	97	PX.				cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			ovary(1)	1						CGAGGAGCGGCGAAAGGGGGC	0.622													4	48					0	0	0	0	T	64802351	T	T	64802351	4	4	134	1	0	0	0	0	0	1	0	0	14950	760	27	1	303	1	SNX15	11	64802351	Nonsense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	6594859	64802351	70204165	45	23962											
MMP7	4316	broad.mit.edu	37	chr11	102401427	102401427	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagcacacagcacggtgagtCgcatagctgccgtccagaga	11	5	12	13	3	0	2	0	1	0	1	2	3	1	2	2	1	4	4	2	1	1	1			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:102401427C>T	uc001phb.2	-	1	52	c.5G>A	c.(4-6)CGA>CAA	p.R2Q	MMP7_uc009yxd.2_Missense_Mutation_p.R2Q|MMP7_uc010rus.1_Missense_Mutation_p.R2Q	NM_002423	NP_002414	P09237	MMP7_HUMAN	matrix metalloproteinase 7 preproprotein	2					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(1)	1	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		CACGGTGAGTCGCATAGCTGC	0.547													5	50					0	0	0	0	T	102401427	T	T	102401427	3	4	134	1	0	0	0	0	1	0	0	0	9720	884	31	1	822	1	MMP7	11	102401427	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	37599076	102401427	32605089	46	23963											
DSCAML1	57453	broad.mit.edu	37	chr11	117335745	117335745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccaccaccccatactgggCgaacttcttgaggttgtcca	9	9	9	14	1	1	1	0	1	1	0	2	3	2	1	5	2	2	1	5	2	2	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr11:117335745C>T	uc001prh.1	-	17	3360	c.3358G>A	c.(3358-3360)GCC>ACC	p.A1120T		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1060	Extracellular (Potential).|Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCATACTGGGCGAACTTCTTG	0.622													6	92					0	0	0	0	T	117335745	T	T	117335745	3	4	134	1	0	0	0	0	1	0	0	0	4791	768	27	1	3051	1	DSCAML1	11	117335745	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	14934318	117335745	17670771	47	23964											
AMIGO2	347902	broad.mit.edu	37	chr12	47472579	47472579	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaggtccagtctcttaatCagtctgaaaaggttcccagg	10	11	9	11	0	4	1	2	1	2	0	7	1	6	1	2	3	0	1	2	3	3	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:47472579C>T	uc001rpm.2	-	3	862	c.207G>A	c.(205-207)CTG>CTA	p.L69L	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Silent_p.L69L|AMIGO2_uc001rpl.2_Silent_p.L69L	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	69	Extracellular (Potential).|LRR 1.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)					GTCTCTTAATCAGTCTGAAAA	0.493													7	66					0	0	0	0	T	47472579	T	T	47472579	2	4	134	1	0	0	0	0	0	0	0	1	576	813	29	2		2	AMIGO2	12	47472579	Silent	SNP	C	TCGA-CR-6492-01A-12D-2078-08		47472579	86379316	48	23965											
VDR	7421	broad.mit.edu	37	chr12	48238570	48238570	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacttcgagcacaaggggcgTtagcttcatgctgcactcag	9	9	11	12	2	2	0	2	0	0	0	3	1	2	0	0	2	4	5	0	2	2	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:48238570T>C	uc001rqm.2	-	11	1525	c.1243A>G	c.(1243-1245)ACG>GCG	p.T415A	VDR_uc001rql.2_Missense_Mutation_p.T465A|VDR_uc001rqn.2_Missense_Mutation_p.T415A|VDR_uc010slq.1_Missense_Mutation_p.T383A	NM_001017535	NP_001017535	P11473	VDR_HUMAN	vitamin D (1,25-dihydroxyvitamin D3) receptor	415	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	ACAAGGGGCGTTAGCTTCATG	0.607													4	31					0	0	0	0	C	48238570	C	C	48238570	3	2	134	1	0	0	0	0	1	0	0	0	17217	1725	60	5	44	5	VDR	12	48238570	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08	765991	48238570	85613325	49	23966											
TENC1	23371	broad.mit.edu	37	chr12	53455639	53455639	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggaccctggggccttcctGatcagggacagtcattcatt	9	10	11	11	0	3	1	3	1	0	0	4	3	4	3	3	4	0	0	3	4	1	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:53455639G>A	uc001sbp.2	+	22	3624	c.3489G>A	c.(3487-3489)CTG>CTA	p.L1163L	TENC1_uc001sbl.2_Silent_p.L1039L|TENC1_uc001sbn.2_Silent_p.L1173L|TENC1_uc001sbq.2_Silent_p.L561L|TENC1_uc001sbr.2_RNA|TENC1_uc009zmr.2_Silent_p.L658L|TENC1_uc001sbs.2_5'UTR	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	1163	SH2.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						GGGCCTTCCTGATCAGGGACA	0.617													12	139					0	0	0	0	A	53455639	A	A	53455639	2	1	134	1	0	0	0	0	0	0	0	1	15824	1277	45	2		2	TENC1	12	53455639	Silent	SNP	G	TCGA-CR-6492-01A-12D-2078-08	5217069	53455639	80396256	50	23967											
RARG	5916	broad.mit.edu	37	chr12	53609131	53609131	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagccggcagtactggcagcGattcctggtcaccttgttga	7	11	12	11	2	1	1	1	1	0	0	2	2	2	1	3	3	3	4	3	3	2	5			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:53609131G>A	uc001sce.2	-	5	906	c.421C>T	c.(421-423)CGC>TGC	p.R141C	RARG_uc001scd.2_Missense_Mutation_p.R130C|RARG_uc010sob.1_Missense_Mutation_p.R119C|RARG_uc001scf.2_Missense_Mutation_p.R141C|RARG_uc001scg.2_Missense_Mutation_p.R69C|RARG_uc010soc.1_Missense_Mutation_p.R20C|RARG_uc010sod.1_Missense_Mutation_p.R178C	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	141	NR C4-type.|Nuclear receptor.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TACTGGCAGCGATTCCTGGTC	0.552													8	85					0	0	0	0	A	53609131	A	A	53609131	3	1	134	1	0	0	0	0	1	0	0	0	13119	1058	37	1	967	1	RARG	12	53609131	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	153492	53609131	80242764	51	23968											
IFT81	28981	broad.mit.edu	37	chr12	110574583	110574583	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttaattgtattttaaagctAtttcatgcagtgcaaagatt	13	18	6	4	0	1	1	1	0	0	1	1	1	1	1	0	0	3	4	0	0	6	9			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr12:110574583A>G	uc001tqi.2	+	8	829	c.699A>G	c.(697-699)CTA>CTG	p.L233L	IFT81_uc001tqh.2_Silent_p.L233L|IFT81_uc001tqj.2_RNA|IFT81_uc001tqg.2_Silent_p.L233L	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	233	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						TTTTAAAGCTATTTCATGCAG	0.348													3	21					0	0	0	0	G	110574583	G	G	110574583	2	3	134	1	0	0	0	0	0	0	0	1	7604	436	16	5		5	IFT81	12	110574583	Silent	SNP	A	TCGA-CR-6492-01A-12D-2078-08	56965452	110574583	23277312	52	23969											
AKAP6	9472	broad.mit.edu	37	chr14	33292535	33292535	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tagcagtgagatgaccaatcCctctgatactctgaatattg	12	12	8	9	0	2	4	0	4	2	1	3	5	3	4	2	0	2	1	2	0	5	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr14:33292535C>G	uc001wrq.2	+	13	5686	c.5516C>G	c.(5515-5517)CCC>CGC	p.P1839R		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1839			P -> T (in a colorectal cancer sample; somatic mutation).		protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding	p.P1839T(1)		breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ATGACCAATCCCTCTGATACT	0.373													4	75					0	0	0	0	G	33292535	G	G	33292535	3	3	134	1	0	0	0	0	1	0	0	0	455	623	22	4	5562	4	AKAP6	14	33292535	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08		33292535	74057005	53	23970											
SLC8A3	6547	broad.mit.edu	37	chr14	70633915	70633915	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagtacagccccacagttctCcaggcactggtaagaacatg	12	7	10	12	0	1	1	0	0	1	1	2	2	1	1	3	2	3	4	3	2	3	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr14:70633915C>G	uc001xly.2	-	2	1979	c.1225G>C	c.(1225-1227)GAG>CAG	p.E409Q	SLC8A3_uc001xlw.2_Missense_Mutation_p.E409Q|SLC8A3_uc001xlx.2_Missense_Mutation_p.E409Q|SLC8A3_uc001xlz.2_Missense_Mutation_p.E409Q|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	409	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CCACAGTTCTCCAGGCACTGG	0.512													15	106					0	0	0	0	G	70633915	G	G	70633915	3	3	134	1	0	0	0	0	1	0	0	0	14772	864	30	2	1697	2	SLC8A3	14	70633915	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	37341380	70633915	36715625	54	23971											
YY1	7528	broad.mit.edu	37	chr14	100728656	100728656	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcagatgaaaaaaaagataTtgaccatgagacagtggttg	17	10	10	4	0	1	5	1	3	0	3	1	6	1	5	1	1	0	1	1	1	5	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr14:100728656T>C	uc001ygy.1	+	2	1175	c.695T>C	c.(694-696)ATT>ACT	p.I232T		NM_003403	NP_003394	P25490	TYY1_HUMAN	YY1 transcription factor	232					cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding				0		Melanoma(154;0.152)				AAAAAAGATATTGACCATGAG	0.333													4	47					0	0	0	0	C	100728656	C	C	100728656	3	2	134	1	0	0	0	0	1	0	0	0	17575	1493	52	5	701	5	YY1	14	100728656	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08	30094741	100728656	6620884	55	23972											
ATP10A	57194	broad.mit.edu	37	chr15	26026297	26026297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatgtccgcagggaagatttCgttgcagcgaagacgcacaa	13	7	12	9	4	0	2	0	0	0	2	2	4	1	3	1	1	2	4	1	1	4	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr15:26026297C>T	uc010ayu.2	-	2	629	c.523G>A	c.(523-525)GAA>AAA	p.E175K		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	175	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGGAAGATTTCGTTGCAGCGA	0.493													3	33					0	0	0	0	T	26026297	T	T	26026297	3	4	134	1	0	0	0	0	1	0	0	0	1118	893	31	1	4056	1	ATP10A	15	26026297	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08		26026297	76505095	56	23973											
TLN2	83660	broad.mit.edu	37	chr15	62942335	62942335	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gacccgaggaaagggatttgGctggaagcgggcagaacact	12	5	16	8	2	0	1	0	0	0	1	0	6	0	4	1	5	2	2	1	5	3	1			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr15:62942335G>A	uc002alb.3	+	2	189	c.189G>A	c.(187-189)TGG>TGA	p.W63*		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	63					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						AAGGGATTTGGCTGGAAGCGG	0.478													7	87					0	0	0	0	A	62942335	A	A	62942335	4	1	134	1	0	0	0	0	0	1	0	0	16014	1212	42	4	195	4	TLN2	15	62942335	Nonsense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	36916038	62942335	39589057	57	23974											
TRAP1	10131	broad.mit.edu	37	chr16	3736066	3736066	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttctggcagtgcttggccGtcagacaccagtttgtgacg	7	12	12	10	2	2	2	1	1	1	1	2	2	2	2	2	2	1	3	2	2	0	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:3736066G>A	uc002cvt.3	-	4	491	c.402C>T	c.(400-402)GAC>GAT	p.D134D	TRAP1_uc010uxf.1_Silent_p.D81D	NM_016292	NP_057376	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1 precursor	134					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(1)	1		Ovarian(90;0.0261)				GTGCTTGGCCGTCAGACACCA	0.532													4	58					0	0	0	0	A	3736066	A	A	3736066	2	1	134	1	0	0	0	0	0	0	0	1	16522	1136	40	1		1	TRAP1	16	3736066	Silent	SNP	G	TCGA-CR-6492-01A-12D-2078-08		3736066	86618687	58	23975											
ZKSCAN2	342357	broad.mit.edu	37	chr16	25255343	25255343	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatgcccgagagttaatcaGggcatccatctccttgtaga	11	10	10	10	1	2	3	1	0	1	3	4	4	3	3	3	1	1	3	3	1	2	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:25255343G>C	uc002dod.3	-	6	2151	c.1744C>G	c.(1744-1746)CTG>GTG	p.L582V	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.L378V	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	582					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		GAGTTAATCAGGGCATCCATC	0.532													7	59					0	0	0	0	C	25255343	C	C	25255343	3	2	134	1	0	0	0	0	1	0	0	0	17754	991	35	4	1167	4	ZKSCAN2	16	25255343	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	21519277	25255343	65099410	59	23976											
ZNF668	79759	broad.mit.edu	37	chr16	31075507	31075507	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcgggtgccgtcttgtaggCcttggggcatagcggacacg	5	9	16	11	4	1	0	0	0	1	0	2	1	1	1	2	5	2	2	2	5	2	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr16:31075507C>G	uc010caf.2	-	2	631	c.274G>C	c.(274-276)GCC>CCC	p.A92P	ZNF668_uc002eao.2_Missense_Mutation_p.A92P|ZNF668_uc010cag.1_Missense_Mutation_p.A92P	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	92	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						GTCTTGTAGGCCTTGGGGCAT	0.667													5	38					0	0	0	0	G	31075507	G	G	31075507	3	3	134	1	0	0	0	0	1	0	0	0	18142	739	26	4	1593	4	ZNF668	16	31075507	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	5820164	31075507	59279246	60	23977											
MYH13	8735	broad.mit.edu	37	chr17	10209914	10209914	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggtgggcgctggtgtcctgTtccttctttagctcctcagc	3	14	12	12	1	2	0	1	0	1	0	5	0	5	0	3	3	2	3	3	3	1	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr17:10209914T>C	uc002gmk.1	-	37	5418	c.5328A>G	c.(5326-5328)GAA>GAG	p.E1776E		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1776	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGGTGTCCTGTTCCTTCTTTA	0.577													9	96					0	0	0	0	C	10209914	C	C	10209914	2	2	134	1	0	0	0	0	0	0	0	1	10085	1722	60	5		5	MYH13	17	10209914	Silent	SNP	T	TCGA-CR-6492-01A-12D-2078-08		10209914	70985296	61	23978											
FAM83G	644815	broad.mit.edu	37	chr17	18882983	18882983	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgctgctccgcactctgaGattctgttttgggaaccaag	7	11	10	13	2	2	1	0	1	2	1	3	3	3	2	3	1	2	4	3	1	2	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr17:18882983G>T	uc002guw.2	-	4	861	c.694C>A	c.(694-696)CTC>ATC	p.L232I	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	232										ovary(1)|central_nervous_system(1)	2						CGCACTCTGAGATTCTGTTTT	0.587													6	89					0.00448238	0.00481976	1	0	T	18882983	T	T	18882983	3	4	134	1	0	0	0	0	1	0	0	0	5671	942	33	2	1789	2	FAM83G	17	18882983	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	8673069	18882983	62312227	62	23979											
VAV1	7409	broad.mit.edu	37	chr19	6829898	6829898	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacagcttccaggttcgggAtgactcttcaggagaccgag	9	8	13	11	2	2	2	1	1	1	1	4	5	3	3	2	3	1	3	2	3	0	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:6829898A>T	uc002mfu.1	+	14	1464	c.1367A>T	c.(1366-1368)GAT>GTT	p.D456V	VAV1_uc010xjh.1_Missense_Mutation_p.D424V|VAV1_uc010dva.1_Missense_Mutation_p.D456V|VAV1_uc002mfv.1_Missense_Mutation_p.D401V	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	456	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CAGGTTCGGGATGACTCTTCA	0.552													4	61					0	0	0	0	T	6829898	T	T	6829898	3	4	134	1	0	0	0	0	1	0	0	0	17199	333	12	5	1421	5	VAV1	19	6829898	Missense_Mutation	SNP	A	TCGA-CR-6492-01A-12D-2078-08		6829898	52299085	63	23980											
KEAP1	9817	broad.mit.edu	37	chr19	10597384	10597384	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcagggctccatggtgacagCcacgcccaccccactccggc	7	4	11	19	2	0	1	0	1	0	0	2	1	2	1	6	3	1	2	6	3	0	0			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:10597384C>G	uc002moq.1	-	6	1975	c.1819G>C	c.(1819-1821)GCT>CCT	p.A607P	KEAP1_uc002mop.1_Missense_Mutation_p.A266P|KEAP1_uc002mor.1_Missense_Mutation_p.A607P	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	607	Kelch 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ATGGTGACAGCCACGCCCACC	0.557													8	122					0	0	0	0	G	10597384	G	G	10597384	3	3	134	1	0	0	0	0	1	0	0	0	8180	739	26	4	59	4	KEAP1	19	10597384	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	3767486	10597384	48531599	64	23981											
ZNF563	147837	broad.mit.edu	37	chr19	12429679	12429679	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgaggtccacctccagtgTgcattatcatgtgtcttcga	8	14	9	10	1	2	1	1	1	1	0	5	2	4	1	3	1	1	1	3	1	2	3			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:12429679T>A	uc002mtp.2	-	4	1398	c.1160A>T	c.(1159-1161)CAC>CTC	p.H387L		NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	387	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACCTCCAGTGTGCATTATCAT	0.418													13	144					0	0	0	0	A	12429679	A	A	12429679	3	1	134	1	0	0	0	0	1	0	0	0	18061	1696	59	5	274	5	ZNF563	19	12429679	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08	1832295	12429679	46699304	65	23982											
GADD45GIP1	90480	broad.mit.edu	37	chr19	13065144	13065144	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgcttgcgctccttcttctCtaggtcctggagcagctcct	3	13	10	15	2	2	0	0	0	2	0	6	1	5	1	3	2	3	4	3	2	1	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:13065144C>T	uc002mwb.2	-	2	571	c.547G>A	c.(547-549)GAG>AAG	p.E183K		NM_052850	NP_443082	Q8TAE8	G45IP_HUMAN	growth arrest and DNA-damage-inducible, gamma	183	Potential.				cell cycle|interspecies interaction between organisms	nucleus	protein binding			ovary(1)|skin(1)	2						TCCTTCTTCTCTAGGTCCTGG	0.627													6	101					0	0	0	0	T	13065144	T	T	13065144	3	4	134	1	0	0	0	0	1	0	0	0	6218	922	32	2	125	2	GADD45GIP1	19	13065144	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08	635465	13065144	46063839	66	23983											
CYTH2	9266	broad.mit.edu	37	chr19	48981788	48981788	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtggtggagggaaaccacAtggtgtaccggatctcggcc	9	7	16	9	2	1	0	0	0	1	0	2	4	1	3	3	6	2	1	3	6	2	1	rs144064799		TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:48981788A>G	uc002pjj.3	+	12	1354	c.1054A>G	c.(1054-1056)ATG>GTG	p.M352V	CYTH2_uc002pji.2_RNA	NM_017457	NP_059431	Q99418	CYH2_HUMAN	cytohesin 2 isoform 1	352	PH.				actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GGGAAACCACATGGTGTACCG	0.463													3	54					0	0	0	0	G	48981788	G	G	48981788	3	3	134	1	0	0	0	0	1	0	0	0	4221	217	8	5	1096	5	CYTH2	19	48981788	Missense_Mutation	SNP	A	TCGA-CR-6492-01A-12D-2078-08	35916644	48981788	10147195	67	23984											
NUP62	23636	broad.mit.edu	37	chr19	50412820	50412820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaatccagttccccccgaaGcaagagtcgctgttccaaaa	14	7	7	13	2	0	1	0	0	0	1	4	2	3	1	5	0	1	4	5	0	6	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr19:50412820G>A	uc002pqx.2	-	2	349	c.245C>T	c.(244-246)GCT>GTT	p.A82V	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.A82V|NUP62_uc002pqz.2_Missense_Mutation_p.A82V|NUP62_uc002pra.2_Missense_Mutation_p.A82V|NUP62_uc002prb.2_Missense_Mutation_p.A82V|NUP62_uc002prc.2_Missense_Mutation_p.A82V	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	82	15 X 9 AA approximate repeats.|Thr-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TCCCCCCGAAGCAAGAGTCGC	0.577													14	131					0	0	0	0	A	50412820	A	A	50412820	3	1	134	1	0	0	0	0	1	0	0	0	10822	971	34	4	1327	4	NUP62	19	50412820	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	1431032	50412820	8716163	68	23985											
MAFB	9935	broad.mit.edu	37	chr20	39317186	39317186	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccgcgtcctcgggcgtcAggttgagcgcctcggggttc	3	8	15	15	6	1	1	1	1	0	0	5	1	2	1	4	4	1	2	4	4	0	2			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr20:39317186A>G	uc002xji.2	-	1	691	c.305T>C	c.(304-306)CTG>CCG	p.L102P		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	102					negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				CTCGGGCGTCAGGTTGAGCGC	0.587			T	IGH@	MM								3	62					0	0	0	0	G	39317186	G	G	39317186	3	3	134	1	0	0	0	0	1	0	0	0	9209	188	7	5	670	5	MAFB	20	39317186	Missense_Mutation	SNP	A	TCGA-CR-6492-01A-12D-2078-08		39317186	23708334	69	23986											
APCDD1L	164284	broad.mit.edu	37	chr20	57035940	57035940	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctggggtgcttctgcagcGatggcctgtgctgcggtggc	2	11	18	10	2	1	0	0	0	1	0	1	1	1	0	1	5	6	4	1	5	0	1	rs147052922	byFrequency	TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr20:57035940G>A	uc002xze.1	-	4	1598	c.1412C>T	c.(1411-1413)TCG>TTG	p.S471L	APCDD1L_uc010zzp.1_Missense_Mutation_p.S482L	NM_153360	NP_699191	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated	471						integral to membrane				ovary(1)	1	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			CTTCTGCAGCGATGGCCTGTG	0.627													4	63					0	0	0	0	A	57035940	A	A	57035940	3	1	134	1	0	0	0	0	1	0	0	0	766	1059	37	1	97	1	APCDD1L	20	57035940	Missense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08	17718754	57035940	5989580	70	23987											
MRPL39	54148	broad.mit.edu	37	chr21	26972131	26972131	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgttggcatccactcatCaagtttgctatccaaaacta	11	15	5	10	0	2	0	2	0	0	0	4	0	4	0	2	1	2	4	2	1	5	6			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:26972131C>G	uc002ylo.2	-	5	582	c.568G>C	c.(568-570)GAT>CAT	p.D190H	MRPL39_uc002yln.2_Missense_Mutation_p.D190H	NM_017446	NP_059142	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39 isoform a	190						mitochondrial ribosome	nucleotide binding				0						ATCCACTCATCAAGTTTGCTA	0.348													3	57					0	0	0	0	G	26972131	G	G	26972131	3	3	134	1	0	0	0	0	1	0	0	0	9855	826	29	2	565	2	MRPL39	21	26972131	Missense_Mutation	SNP	C	TCGA-CR-6492-01A-12D-2078-08		26972131	21157764	71	23988											
UBE2G2	7327	broad.mit.edu	37	chr21	46193489	46193489	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgctcaccaccgacagcaGgatcttctccacactctgca	10	8	6	17	1	4	0	1	0	3	0	5	2	4	1	3	1	3	3	3	1	0	1			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:46193489G>A	uc002zfy.2	-	5	433	c.358C>T	c.(358-360)CTG>TTG	p.L120L	UBE2G2_uc002zfx.2_Silent_p.L92L	NM_003343	NP_003334	P60604	UB2G2_HUMAN	ubiquitin-conjugating enzyme E2G 2 isoform 1	120					protein K48-linked ubiquitination	cytosol	ATP binding|protein binding|ubiquitin-protein ligase activity			breast(3)|central_nervous_system(1)	4				Colorectal(79;0.0638)		ACCGACAGCAGGATCTTCTCC	0.637													4	35					0	0	0	0	A	46193489	A	A	46193489	2	1	134	1	0	0	0	0	0	0	0	1	16925	991	35	4		4	UBE2G2	21	46193489	Silent	SNP	G	TCGA-CR-6492-01A-12D-2078-08	19221358	46193489	1936406	72	23989											
COL18A1	80781	broad.mit.edu	37	chr21	46875807	46875807	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgaacgtggccaaaggcatCcggagcttcgtccagctgtg	8	8	13	12	3	0	1	0	1	0	0	3	2	2	2	3	3	3	3	3	3	2	1			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:46875807C>T	uc011afs.1	+	1	384	c.363C>T	c.(361-363)ATC>ATT	p.I121I	COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Silent_p.I121I	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	121					cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CCAAAGGCATCCGGAGCTTCG	0.642													8	80					0	0	0	0	T	46875807	T	T	46875807	2	4	134	1	0	0	0	0	0	0	0	1	3690	845	30	2		2	COL18A1	21	46875807	Silent	SNP	C	TCGA-CR-6492-01A-12D-2078-08	682318	46875807	1254088	73	23990											
MCM3AP	8888	broad.mit.edu	37	chr21	47700039	47700039	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctccttcagggaaaagggtTtcttattggggcctgtggac	7	13	13	8	0	3	0	1	0	2	0	4	2	3	2	2	5	0	1	2	5	3	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr21:47700039T>A	uc002zir.1	-	4	1571	c.1535A>T	c.(1534-1536)AAA>ATA	p.K512I		NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	512					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					GGAAAAGGGTTTCTTATTGGG	0.483													8	126					0	0	0	0	A	47700039	A	A	47700039	3	1	134	1	0	0	0	0	1	0	0	0	9441	1841	64	5	4507	5	MCM3AP	21	47700039	Missense_Mutation	SNP	T	TCGA-CR-6492-01A-12D-2078-08	824232	47700039	429856	74	23991											
C22orf29	79680	broad.mit.edu	37	chr22	19839545	19839545	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcatgtgcccagctaggggAcccctttctgcaggtttacc	6	10	12	13	0	1	0	0	0	1	0	1	1	1	1	4	4	4	4	4	4	2	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chr22:19839545A>T	uc002zqg.2	-	2	839	c.240T>A	c.(238-240)GGT>GGA	p.G80G	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Silent_p.G80G|C22orf29_uc002zqi.2_Silent_p.G80G|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	80											0	Colorectal(54;0.0993)					CAGCTAGGGGACCCCTTTCTG	0.627													11	50					0	0	0	0	T	19839545	T	T	19839545	2	4	134	1	0	0	0	0	0	0	0	1	2151	262	10	5		5	C22orf29	22	19839545	Silent	SNP	A	TCGA-CR-6492-01A-12D-2078-08		19839545	31465021	75	23992											
PRICKLE3	4007	broad.mit.edu	37	chrX	49032203	49032203	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagccatcatcctctgatGattcggaactggaactggag	12	9	11	9	1	2	3	1	2	1	1	4	6	3	6	2	3	3	0	2	3	3	1			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chrX:49032203G>T	uc004dmy.1	-	9	1693	c.1667C>A	c.(1666-1668)TCA>TAA	p.S556*	PRICKLE3_uc011mmv.1_Nonsense_Mutation_p.S488*|PRICKLE3_uc011mmw.1_Nonsense_Mutation_p.S475*|PRICKLE3_uc011mmx.1_Nonsense_Mutation_p.S518*	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	556	Poly-Ser.						protein binding|zinc ion binding			breast(1)	1						ATCCTCTGATGATTCGGAACT	0.577													15	75					1.15088e-07	1.27875e-07	1	0	T	49032203	T	T	49032203	4	4	134	1	0	0	0	0	0	1	0	0	12550	1294	45	2	184	2	PRICKLE3	23	49032203	Nonsense_Mutation	SNP	G	TCGA-CR-6492-01A-12D-2078-08		49032203	106238357	76	23993											
HCFC1	3054	broad.mit.edu	37	chrX	153215722	153215722	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cacctcacttgtgtggccggGccatagcccttctcattgcg	5	11	10	15	2	2	0	2	0	1	0	3	0	2	0	4	2	2	0	4	2	1	4			TCGA-CR-6492-01A-12D-2078-08	TCGA-CR-6492-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4550d39-4f32-48ab-b049-2fe623332d07	b2e7e876-1d03-4a50-bfb4-1e5865600181	g.chrX:153215722G>C	uc004fjp.2	-	24	6504	c.5976C>G	c.(5974-5976)GGC>GGG	p.G1992G		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1992					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGTGGCCGGGCCATAGCCCT	0.632													7	32					0	0	0	0	C	153215722	C	C	153215722	2	2	134	1	0	0	0	0	0	0	0	1	7030	1190	42	4		4	HCFC1	23	153215722	Silent	SNP	G	TCGA-CR-6492-01A-12D-2078-08	104183519	153215722	2054838	77	23994											
CDK11B	984	broad.mit.edu	37	chr1	1650803	1650803	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctatgatgcctacatttttCttttctcttttcatcttttc	5	23	3	10	0	4	1	1	1	3	0	6	1	4	1	1	0	2	1	1	0	2	10			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr1:1650803C>G	uc001agv.1	-	6	430	c.319G>C	c.(319-321)GAG>CAG	p.E107Q	CDK11B_uc001ags.1_5'Flank|CDK11B_uc001agt.1_5'Flank|CDK11B_uc001aha.1_Missense_Mutation_p.E73Q|CDK11B_uc001agw.1_Missense_Mutation_p.E73Q|CDK11B_uc001agy.1_Missense_Mutation_p.E107Q|CDK11B_uc001agx.1_Missense_Mutation_p.E107Q|CDK11B_uc001agz.1_5'UTR|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc009vkr.2_Missense_Mutation_p.E107Q|CDK11A_uc009vks.2_Missense_Mutation_p.E107Q|CDK11A_uc010nys.1_Missense_Mutation_p.E107Q|CDK11A_uc010nyt.1_Missense_Mutation_p.E107Q|CDK11A_uc010nyu.1_RNA|CDK11A_uc009vkt.1_Missense_Mutation_p.E107Q|CDK11A_uc009vku.1_Missense_Mutation_p.E107Q|CDK11A_uc009vkv.1_Missense_Mutation_p.E107Q|CDK11A_uc001aht.1_Missense_Mutation_p.E107Q|CDK11B_uc001ahu.1_Missense_Mutation_p.E107Q|CDK11B_uc001ahv.1_Missense_Mutation_p.E107Q|CDK11B_uc001ahw.1_Missense_Mutation_p.E107Q	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	107					apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CTACATTTTTCTTTTCTCTTT	0.388													38	127					0	0	0	0	G	1650803	G	G	1650803	3	3	135	1	0	0	0	0	1	0	0	0	3142	922	32	2	2118	2	CDK11B	1	1650803	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08		1650803	247599818	1	23995											
COL11A1	1301	broad.mit.edu	37	chr1	103461591	103461591	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caataggaccttgtggaccaGggggaccctgaaatagatga	13	7	13	8	0	0	3	0	2	0	1	0	6	0	6	3	4	0	0	3	4	4	3			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr1:103461591G>A	uc001dul.2	-	27	2567	c.2249C>T	c.(2248-2250)CCT>CTT	p.P750L	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.P762L|COL11A1_uc001dun.2_Missense_Mutation_p.P711L|COL11A1_uc009weh.2_Missense_Mutation_p.P634L	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	750	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTGTGGACCAGGGGGACCCTG	0.358													23	87					0	0	0	0	A	103461591	A	A	103461591	3	1	135	1	0	0	0	0	1	0	0	0	3682	1000	35	4	3335	4	COL11A1	1	103461591	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08	101810788	103461591	145789030	2	23996											
PMVK	10654	broad.mit.edu	37	chr1	154897618	154897618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctagtgactaaagtctggagCggataaattctatcaggttc	12	12	10	7	1	3	1	1	1	2	0	4	3	3	3	0	3	1	1	0	3	6	6			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr1:154897618C>T	uc001ffq.2	-	5	889	c.566G>A	c.(565-567)CGC>CAC	p.R189H		NM_006556	NP_006547	Q15126	PMVK_HUMAN	phosphomevalonate kinase	189					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding				0	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AAGTCTGGAGCGGATAAATTC	0.572													68	116					0	0	0	0	T	154897618	T	T	154897618	3	4	135	1	0	0	0	0	1	0	0	0	12199	768	27	1	16	1	PMVK	1	154897618	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08	51436027	154897618	94353003	3	23997											
CACNA1E	777	broad.mit.edu	37	chr1	181767512	181767512	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgtcggcagctcccacccGtcccgccaaagccccggccc	5	4	10	22	5	0	0	0	0	0	0	4	0	2	0	7	2	2	2	7	2	1	0			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr1:181767512G>A	uc001gow.2	+	47	6520	c.6355G>A	c.(6355-6357)GTC>ATC	p.V2119I	CACNA1E_uc009wxs.2_Missense_Mutation_p.V2007I|CACNA1E_uc009wxt.2_Missense_Mutation_p.V1388I	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2162	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GCTCCCACCCGTCCCGCCAAA	0.627													43	94					0	0	0	0	A	181767512	A	A	181767512	3	1	135	1	0	0	0	0	1	0	0	0	2554	1145	40	1	6541	1	CACNA1E	1	181767512	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08	26869894	181767512	67483109	4	23998											
PTPRC	5788	broad.mit.edu	37	chr1	198711143	198711143	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttcagtggtcccattgTggtgcactgcaggtaggaaa	8	13	12	8	0	2	0	1	0	1	0	3	1	3	1	1	4	2	3	1	4	2	4			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr1:198711143T>C	uc001gur.1	+	24	2723	c.2543T>C	c.(2542-2544)GTG>GCG	p.V848A	PTPRC_uc001gus.1_Missense_Mutation_p.V800A|PTPRC_uc001gut.1_Missense_Mutation_p.V687A	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	848	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GGTCCCATTGTGGTGCACTGC	0.473													5	22					0	0	0	0	C	198711143	C	C	198711143	3	2	135	1	0	0	0	0	1	0	0	0	12862	1696	59	5	2644	5	PTPRC	1	198711143	Missense_Mutation	SNP	T	TCGA-CR-6493-01A-11D-1870-08	16943631	198711143	50539478	5	23999											
LTBP1	4052	broad.mit.edu	37	chr2	33623487	33623487	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctctgcaagaatgccaagTgcattaacaccgatggttcc	11	10	8	12	1	1	1	0	0	1	1	3	2	2	1	3	1	4	3	3	1	4	2			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr2:33623487T>C	uc002ros.2	+	34	5044	c.5044T>C	c.(5044-5046)TGC>CGC	p.C1682R	LTBP1_uc002rot.2_Missense_Mutation_p.C1356R|LTBP1_uc002rou.2_Missense_Mutation_p.C1355R|LTBP1_uc002rov.2_Missense_Mutation_p.C1302R|LTBP1_uc010ymz.1_Missense_Mutation_p.C1313R|LTBP1_uc010yna.1_Missense_Mutation_p.C1260R|LTBP1_uc010ynb.1_Missense_Mutation_p.C579R	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1681	EGF-like 18; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GAATGCCAAGTGCATTAACAC	0.438													40	50					0	0	0	0	C	33623487	C	C	33623487	3	2	135	1	0	0	0	0	1	0	0	0	9123	1696	59	5	5230	5	LTBP1	2	33623487	Missense_Mutation	SNP	T	TCGA-CR-6493-01A-11D-1870-08		33623487	209575886	6	24000											
CYP27C1	339761	broad.mit.edu	37	chr2	127958736	127958736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggacctgcagaattccCgccagggctttgggatgaag	9	7	13	12	1	0	2	0	1	0	1	1	4	1	4	4	3	1	2	4	3	2	2			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr2:127958736C>T	uc002tod.2	-	3	481	c.350G>A	c.(349-351)CGG>CAG	p.R117Q		NM_001001665	NP_001001665	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C,	117						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		GCAGAATTCCCGCCAGGGCTT	0.522													64	118					0	0	0	0	T	127958736	T	T	127958736	3	4	135	1	0	0	0	0	1	0	0	0	4177	652	23	1	792	1	CYP27C1	2	127958736	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08	94335249	127958736	115240637	7	24001											
CPS1	1373	broad.mit.edu	37	chr2	211441130	211441130	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attctcacaatggccaacccTattattgggaatggtggagc	11	11	10	9	0	1	0	1	0	1	0	2	2	1	2	2	4	2	0	2	4	5	4			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr2:211441130T>C	uc002vee.3	+	3	429	c.297T>C	c.(295-297)CCT>CCC	p.P99P	CPS1_uc010fur.2_Silent_p.P105P	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	99	Anthranilate phosphoribosyltransferase homolog.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGGCCAACCCTATTATTGGGA	0.428													3	117					0	0	0	0	C	211441130	C	C	211441130	2	2	135	1	0	0	0	0	0	0	0	1	3838	1509	53	5		5	CPS1	2	211441130	Silent	SNP	T	TCGA-CR-6493-01A-11D-1870-08	83482394	211441130	31758243	8	24002											
NKTR	4820	broad.mit.edu	37	chr3	42676726	42676726	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaaagcgctatcacacacCtccaagatcaagatcctgtt	13	11	5	12	1	2	2	2	0	0	2	4	2	4	2	3	0	1	2	3	0	5	4			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr3:42676726C>G	uc003clo.2	+	12	1178	c.1031C>G	c.(1030-1032)CCT>CGT	p.P344R	NKTR_uc003clm.1_Missense_Mutation_p.P91R|NKTR_uc003clp.2_Missense_Mutation_p.P91R|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.P234R|NKTR_uc003clr.1_Missense_Mutation_p.P91R|NKTR_uc003cls.2_Missense_Mutation_p.P44R	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	344					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TATCACACACCTCCAAGATCA	0.398													31	9					0	0	0	0	G	42676726	G	G	42676726	3	3	135	1	0	0	0	0	1	0	0	0	10502	681	24	4	1073	4	NKTR	3	42676726	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08		42676726	155345704	9	24003											
NKTR	4820	broad.mit.edu	37	chr3	42680280	42680280	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttggtgaagaggaggaggaGgagattgatgacaagcaagt	14	8	17	2	0	0	5	0	3	0	2	0	9	0	8	0	5	1	1	0	5	3	2			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr3:42680280G>T	uc003clo.2	+	13	3231	c.3084G>T	c.(3082-3084)GAG>GAT	p.E1028D	NKTR_uc003clm.1_Missense_Mutation_p.E775D|NKTR_uc003clp.2_Missense_Mutation_p.E775D|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.E918D|NKTR_uc003clr.1_Missense_Mutation_p.E775D|NKTR_uc003cls.2_Missense_Mutation_p.E728D	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1028					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		AGGAGGAGGAGGAGATTGATG	0.358													48	22					2.74695e-27	3.17785e-27	1	0	T	42680280	T	T	42680280	3	4	135	1	0	0	0	0	1	0	0	0	10502	991	35	4	3130	4	NKTR	3	42680280	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08	3554	42680280	155342150	10	24004											
BOC	91653	broad.mit.edu	37	chr3	112993314	112993314	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaccctgagcagatgctgAgggggcaaccggcgctcccc	8	4	14	15	2	0	3	0	2	0	1	1	3	1	3	4	3	4	5	4	3	2	0			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr3:112993314A>G	uc003dzx.2	+	9	1948	c.1327A>G	c.(1327-1329)AGG>GGG	p.R443G	BOC_uc003dzy.2_Missense_Mutation_p.R443G|BOC_uc003dzz.2_Missense_Mutation_p.R443G|BOC_uc003eab.2_Missense_Mutation_p.R144G	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	443	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GCAGATGCTGAGGGGGCAACC	0.652													36	36					0	0	0	0	G	112993314	G	G	112993314	3	3	135	1	0	0	0	0	1	0	0	0	1484	295	11	5	1353	5	BOC	3	112993314	Missense_Mutation	SNP	A	TCGA-CR-6493-01A-11D-1870-08	70313034	112993314	85029116	11	24005											
DNAJB11	51726	broad.mit.edu	37	chr3	186295532	186295534	+	In_Frame_Del	DEL	TAT	-	-																															aatattccaagaggaagtgaTattattgtagatctagaagt																										TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr3:186295532_186295534delTAT	uc003fqi.2	+	4	619_621	c.399_401delTAT	c.(397-402)GATATT>GAT	p.I135del		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	135					protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		GAGGAAGTGATATTATTGTAGAT	0.369													---	---	---								-	186295534	-	-	186295532	7	5	135	1	0	1	0	1	0	0	0	0	4638	1403	49	0	413	0	DNAJB11	3	186295532	In_Frame_Del	DEL	TAT	TCGA-CR-6493-01A-11D-1870-08	73302218	186295532	11726898	12	24006											
PLK4	10733	broad.mit.edu	37	chr4	128812740	128812740	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaatcttttggcagatcactAtttattatccaaatggtggt	12	16	7	6	0	2	1	1	0	1	1	3	1	3	1	1	3	0	1	1	3	5	6	rs11552117		TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr4:128812740A>G	uc003ifo.2	+	9	2187	c.1942A>G	c.(1942-1944)ATT>GTT	p.I648V	PLK4_uc011cgs.1_Missense_Mutation_p.I616V|PLK4_uc011cgt.1_Missense_Mutation_p.I607V	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	648					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GCAGATCACTATTTATTATCC	0.338													53	97					0	0	0	0	G	128812740	G	G	128812740	3	3	135	1	0	0	0	0	1	0	0	0	12153	449	16	5	1976	5	PLK4	4	128812740	Missense_Mutation	SNP	A	TCGA-CR-6493-01A-11D-1870-08		128812740	62341536	13	24007											
AFF4	27125	broad.mit.edu	37	chr5	132269985	132269985	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcctgtccgtccatgggccGcacataggcagtgggtttct	5	11	12	13	2	1	0	0	0	1	0	4	0	4	0	4	3	0	3	4	3	1	2			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr5:132269985G>A	uc003kyd.2	-	3	1180	c.772C>T	c.(772-774)CGG>TGG	p.R258W	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Missense_Mutation_p.R258W|AFF4_uc003kyf.3_Missense_Mutation_p.R258W	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	258	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCCATGGGCCGCACATAGGCA	0.517													4	95					0	0	0	0	A	132269985	A	A	132269985	3	1	135	1	0	0	0	0	1	0	0	0	359	1086	38	1	2795	1	AFF4	5	132269985	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08		132269985	48645275	14	24008											
PCDHB8	56128	broad.mit.edu	37	chr5	140559714	140559714	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcgttggcctcggtgtcttCgctcttcctcttctcggtgc	0	15	12	14	4	4	0	0	0	4	0	8	0	5	0	2	4	1	2	2	4	0	4			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr5:140559714C>T	uc011dai.1	+	1	2285	c.2099C>T	c.(2098-2100)TCG>TTG	p.S700L	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	700	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGTGTCTTCGCTCTTCCTC	0.672													134	38					0	0	0	0	T	140559714	T	T	140559714	3	4	135	1	0	0	0	0	1	0	0	0	11602	893	31	1	2101	1	PCDHB8	5	140559714	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08	8289729	140559714	40355546	15	24009											
NT5E	4907	broad.mit.edu	37	chr6	86197162	86197162	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gatggctcctctcaatcatgCcgctttagagaatgcaacat	11	11	8	11	1	2	1	2	0	1	1	4	3	3	1	2	1	3	3	2	1	4	2			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr6:86197162C>T	uc003pko.3	+	5	1615	c.1059C>T	c.(1057-1059)TGC>TGT	p.C353C	NT5E_uc010kbr.2_Silent_p.C353C	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	353					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	CTCAATCATGCCGCTTTAGAG	0.348													5	185					0	0	0	0	T	86197162	T	T	86197162	2	4	135	1	0	0	0	0	0	0	0	1	10747	747	26	4		4	NT5E	6	86197162	Silent	SNP	C	TCGA-CR-6493-01A-11D-1870-08		86197162	84917905	16	24010											
SP8	221833	broad.mit.edu	37	chr7	20825289	20825289	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gacgaggagcgtttccagggGtggaagcctttgccgaagga	9	7	17	8	3	0	0	0	0	0	0	1	6	1	3	3	5	3	1	3	5	2	2			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr7:20825289G>A	uc003suy.2	-	3	334	c.93C>T	c.(91-93)CAC>CAT	p.H31H	SP8_uc003suz.2_Silent_p.H49H	NM_198956	NP_945194	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor isoform 2	31	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						GTTTCCAGGGGTGGAAGCCTT	0.617													21	42					0	0	0	0	A	20825289	A	A	20825289	2	1	135	1	0	0	0	0	0	0	0	1	15034	1252	44	4		4	SP8	7	20825289	Silent	SNP	G	TCGA-CR-6493-01A-11D-1870-08		20825289	138313374	17	24011											
ABCB4	5244	broad.mit.edu	37	chr7	87051469	87051469	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agtaaaaaaagaaataattcCcagaaataagaaaatcaaag	26	6	5	4	0	1	3	1	0	0	3	2	3	2	3	1	0	0	1	1	0	11	4			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr7:87051469C>T	uc003uiv.1	-	18	2360	c.2284G>A	c.(2284-2286)GGA>AGA	p.G762R	ABCB4_uc003uiw.1_Missense_Mutation_p.G762R|ABCB4_uc003uix.1_Missense_Mutation_p.G762R	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	762	Helical; (By similarity).|ABC transmembrane type-1 2.		G -> E (in ICP).		cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GAAATAATTCCCAGAAATAAG	0.318													3	15					0	0	0	0	T	87051469	T	T	87051469	3	4	135	1	0	0	0	0	1	0	0	0	43	632	22	4	1620	4	ABCB4	7	87051469	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08	66226180	87051469	72087194	18	24012											
ZNF282	8427	broad.mit.edu	37	chr7	148909533	148909533	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggatcagcaggatttggcaGacagagatattcccacggat	12	8	13	8	1	1	2	1	0	0	2	2	6	2	5	1	4	1	2	1	4	1	3			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr7:148909533G>A	uc003wfm.2	+	6	1141	c.1036G>A	c.(1036-1038)GAC>AAC	p.D346N	ZNF282_uc011kun.1_Missense_Mutation_p.D346N|ZNF282_uc003wfn.2_Missense_Mutation_p.D286N|ZNF282_uc003wfo.2_Intron	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	346					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		GGATTTGGCAGACAGAGATAT	0.353													3	31					0	0	0	0	A	148909533	A	A	148909533	3	1	135	1	0	0	0	0	1	0	0	0	17886	942	33	2	1058	2	ZNF282	7	148909533	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08	61858064	148909533	10229130	19	24013											
DPY19L4	286148	broad.mit.edu	37	chr8	95802031	95802031	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatatgggcgattttgtcatGaggtcaaaattaactattct	13	15	8	5	1	3	1	2	1	1	0	3	2	3	1	0	2	1	0	0	2	6	6			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr8:95802031G>A	uc003ygx.2	+	19	2189	c.2065G>A	c.(2065-2067)GAG>AAG	p.E689K		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	689						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					ATTTTGTCATGAGGTCAAAAT	0.303													98	188					0	0	0	0	A	95802031	A	A	95802031	3	1	135	1	0	0	0	0	1	0	0	0	4765	1291	45	2	2139	2	DPY19L4	8	95802031	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08		95802031	50561991	20	24014											
SECISBP2	79048	broad.mit.edu	37	chr9	91972404	91972404	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctttgtgtttgctctcaaccGcaaagctctggggcgcagtt	6	13	11	11	2	2	0	1	0	2	0	3	0	2	0	1	2	3	6	1	2	2	3			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr9:91972404G>A	uc004aqj.1	+	15	2272	c.2192G>A	c.(2191-2193)CGC>CAC	p.R731H	SECISBP2_uc011ltk.1_Missense_Mutation_p.R730H|SECISBP2_uc004aqk.1_Missense_Mutation_p.R658H|SECISBP2_uc010mqo.1_Missense_Mutation_p.R436H|SECISBP2_uc011ltl.1_Missense_Mutation_p.R663H	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	731					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						GCTCTCAACCGCAAAGCTCTG	0.507													6	205					0	0	0	0	A	91972404	A	A	91972404	3	1	135	1	0	0	0	0	1	0	0	0	14071	1087	38	1	2250	1	SECISBP2	9	91972404	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08		91972404	49241027	21	24015											
SUSD1	64420	broad.mit.edu	37	chr9	114886703	114886703	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccgcatttctggagggttGccacagttgatctctgcaat	7	13	11	10	1	2	1	0	1	2	0	3	2	2	2	2	2	3	4	2	2	1	3			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr9:114886703G>A	uc004bfu.2	-	6	761	c.720C>T	c.(718-720)GGC>GGT	p.G240G	SUSD1_uc010mui.2_Silent_p.G240G|SUSD1_uc010muj.2_Silent_p.G240G	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	240	Sushi 2.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						CTGGAGGGTTGCCACAGTTGA	0.483													76	39					0	0	0	0	A	114886703	A	A	114886703	2	1	135	1	0	0	0	0	0	0	0	1	15473	1306	46	4		4	SUSD1	9	114886703	Silent	SNP	G	TCGA-CR-6493-01A-11D-1870-08	22914299	114886703	26326728	22	24016											
OR1N1	138883	broad.mit.edu	37	chr9	125288894	125288894	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccaccccaccacgggttcGgaccctcaggatagctggca	8	5	11	17	2	1	0	1	0	0	0	2	2	1	2	5	4	1	3	5	4	1	2			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr9:125288894G>A	uc004bmn.1	-	1	679	c.679C>T	c.(679-681)CGA>TGA	p.R227*		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						CCACGGGTTCGGACCCTCAGG	0.542													44	31					0	0	0	0	A	125288894	A	A	125288894	4	1	135	1	0	0	0	0	0	1	0	0	11023	1124	39	1	260	1	OR1N1	9	125288894	Nonsense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08	10402191	125288894	15924537	23	24017											
SNAPC4	6621	broad.mit.edu	37	chr9	139273678	139273678	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcgctccacccggctggaCgccagtcttcggctcccttt	3	10	11	17	4	1	0	0	0	1	0	4	1	3	1	4	3	1	3	4	3	0	2			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr9:139273678C>A	uc004chh.2	-	21	2610	c.2601G>T	c.(2599-2601)GCG>GCT	p.A867A		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	867					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CCCGGCTGGACGCCAGTCTTC	0.642													6	30					8.12818e-05	8.41338e-05	1	0	A	139273678	A	A	139273678	2	1	135	1	0	0	0	0	0	0	0	1	14901	523	19	3		3	SNAPC4	9	139273678	Silent	SNP	C	TCGA-CR-6493-01A-11D-1870-08	13984784	139273678	1939753	24	24018											
CUBN	8029	broad.mit.edu	37	chr10	16942822	16942822	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccaagcacaagttgtatgggGttcaatatcaaagtcactaa	15	10	8	8	0	3	0	3	0	0	0	3	0	3	0	1	2	1	4	1	2	7	5			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr10:16942822G>A	uc001ioo.2	-	53	8264	c.8212C>T	c.(8212-8214)CCC>TCC	p.P2738S	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.P94S	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2738	CUB 20.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTTGTATGGGGTTCAATATCA	0.433													3	29					0	0	0	0	A	16942822	A	A	16942822	3	1	135	1	0	0	0	0	1	0	0	0	4068	1261	44	4	2719	4	CUBN	10	16942822	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08		16942822	118591925	25	24019											
POLR2L	5441	broad.mit.edu	37	chr11	840466	840466	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agtagcgcttcaggcccaggGcatccagcgcatccctgtgt	7	8	12	14	2	1	0	1	0	0	0	3	0	3	0	3	2	2	4	3	2	1	2			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr11:840466G>T	uc001lsc.2	-	2	131	c.110C>A	c.(109-111)GCC>GAC	p.A37D	TSPAN4_uc001lsd.1_5'Flank|TSPAN4_uc001lse.1_5'Flank|TSPAN4_uc001lsf.1_5'Flank|TSPAN4_uc001lsg.1_5'Flank|TSPAN4_uc001lsh.1_5'Flank	NM_021128	NP_066951	P62875	RPAB5_HUMAN	DNA directed RNA polymerase II polypeptide L	37					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|zinc ion binding				0		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;4.1e-25)|Epithelial(43;3.15e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAGGCCCAGGGCATCCAGCGC	0.622													41	75					7.53189e-24	8.5458e-24	1	0	T	840466	T	T	840466	3	4	135	1	0	0	0	0	1	0	0	0	12282	1203	42	4	97	4	POLR2L	11	840466	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08		840466	134166050	26	24020											
FAM90A1	55138	broad.mit.edu	37	chr12	8375146	8375146	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcggcttcaccacgaggaGaggctcggggccctggtgcc	5	7	16	13	3	1	1	1	0	0	1	3	3	1	1	3	6	1	2	3	6	0	1			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr12:8375146G>C	uc001qui.2	-	7	1226	c.667C>G	c.(667-669)CTC>GTC	p.L223V	FAM90A1_uc001quh.2_Missense_Mutation_p.L223V	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	223							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		ACCACGAGGAGAGGCTCGGGG	0.647													33	57					0	0	0	0	C	8375146	C	C	8375146	3	2	135	1	0	0	0	0	1	0	0	0	5682	942	33	2	731	2	FAM90A1	12	8375146	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08		8375146	125476749	27	24021											
PIP4K2C	79837	broad.mit.edu	37	chr12	57988994	57988994	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgatttggcattgatgacCaagattacttggtgagagtc	11	13	11	6	1	0	4	0	3	0	2	2	6	0	4	1	2	1	1	1	2	2	4			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr12:57988994C>T	uc001sou.2	+	3	489	c.358C>T	c.(358-360)CAA>TAA	p.Q120*	PIP4K2C_uc001sot.2_Nonsense_Mutation_p.Q120*|PIP4K2C_uc010srs.1_Nonsense_Mutation_p.Q102*|PIP4K2C_uc010srt.1_Nonsense_Mutation_p.Q120*	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	120	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					CATTGATGACCAAGATTACTT	0.463													130	147					0	0	0	0	T	57988994	T	T	57988994	4	4	135	1	0	0	0	0	0	1	0	0	11993	595	21	4	368	4	PIP4K2C	12	57988994	Nonsense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08	49613848	57988994	75862901	28	24022											
SACS	26278	broad.mit.edu	37	chr13	23906082	23906082	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttcatctaattgttcttcaAgtatactgctcaataatcga	12	16	4	9	1	5	0	3	0	2	0	6	1	5	0	0	0	2	3	0	0	6	8			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr13:23906082A>C	uc001uon.2	-	10	12522	c.11933T>G	c.(11932-11934)CTT>CGT	p.L3978R	SACS_uc001uoo.2_Missense_Mutation_p.L3831R|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3978					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTGTTCTTCAAGTATACTGCT	0.398													23	79					0	0	0	0	C	23906082	C	C	23906082	3	2	135	1	0	0	0	0	1	0	0	0	13869	72	3	5	1810	5	SACS	13	23906082	Missense_Mutation	SNP	A	TCGA-CR-6493-01A-11D-1870-08		23906082	91263796	29	24023											
JUB	84962	broad.mit.edu	37	chr14	23445688	23445688	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaaaatcaagtgaccacAgacacagcatttctcagctg	14	8	6	13	0	2	2	2	1	1	1	4	2	3	2	2	0	2	2	2	0	3	1			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr14:23445688A>T	uc001whz.2	-	4	1592	c.1216T>A	c.(1216-1218)TGT>AGT	p.C406S	JUB_uc001why.2_5'UTR	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	406	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		AAGTGACCACAGACACAGCAT	0.453													114	60					0	0	0	0	T	23445688	T	T	23445688	3	4	135	1	0	0	0	0	1	0	0	0	8007	188	7	5	420	5	JUB	14	23445688	Missense_Mutation	SNP	A	TCGA-CR-6493-01A-11D-1870-08		23445688	83903852	30	24024											
ACOT1	641371	broad.mit.edu	37	chr14	74004392	74004392	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttggagcccgagaaaccCttggtgcggctggtgaagcg	7	7	16	11	3	0	2	0	1	0	1	0	4	0	3	3	4	4	1	3	4	2	2			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr14:74004392C>T	uc001xol.1	+	1	465	c.267C>T	c.(265-267)CCC>CCT	p.P89P	HEATR4_uc010tua.1_Intron|ACOT1_uc010tuc.1_Silent_p.P89P	NM_001037161	NP_001032238	Q86TX2	ACOT1_HUMAN	acyl-CoA thioesterase 1	89					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	cytosol	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(108;1.37e-45)|BRCA - Breast invasive adenocarcinoma(234;0.0033)		CCGAGAAACCCTTGGTGCGGC	0.736													4	16					0	0	0	0	T	74004392	T	T	74004392	2	4	135	1	0	0	0	0	0	0	0	1	148	668	24	4		4	ACOT1	14	74004392	Silent	SNP	C	TCGA-CR-6493-01A-11D-1870-08	50558704	74004392	33345148	31	24025											
CDAN1	146059	broad.mit.edu	37	chr15	43023151	43023151	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagggccagaatggagtccTgaagctcaccggtcggggga	9	6	17	9	2	1	3	1	2	0	1	3	5	2	5	3	5	1	1	3	5	2	0			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr15:43023151T>C	uc001zql.2	-	13	2096	c.1979A>G	c.(1978-1980)CAG>CGG	p.Q660R	CDAN1_uc001zqj.2_5'Flank|CDAN1_uc001zqk.2_5'UTR	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	660						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		AATGGAGTCCTGAAGCTCACC	0.607													4	132					0	0	0	0	C	43023151	C	C	43023151	3	2	135	1	0	0	0	0	1	0	0	0	3069	1580	55	5	1768	5	CDAN1	15	43023151	Missense_Mutation	SNP	T	TCGA-CR-6493-01A-11D-1870-08		43023151	59508241	32	24026											
ISL2	64843	broad.mit.edu	37	chr15	76633517	76633517	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgcccctggtggcgggcagtCccatccgccatgagaacgcc	6	5	13	17	4	0	1	0	1	0	1	2	2	2	1	6	3	1	1	6	3	1	0			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr15:76633517C>G	uc002bbw.1	+	5	916	c.838C>G	c.(838-840)CCC>GCC	p.P280A		NM_145805	NP_665804	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	280						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGCGGGCAGTCCCATCCGCCA	0.657													15	29					0	0	0	0	G	76633517	G	G	76633517	3	3	135	1	0	0	0	0	1	0	0	0	7896	855	30	2	856	2	ISL2	15	76633517	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08	33610366	76633517	25897875	33	24027											
SEPX1	51734	broad.mit.edu	37	chr16	1991308	1991308	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcttggccacgctgtcggCgtgaatggtctcggtgaacg	6	9	15	11	6	1	2	0	2	1	0	3	2	1	2	1	4	1	2	1	4	2	1			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr16:1991308C>T	uc010uvs.1	-	2	291	c.154G>A	c.(154-156)GCC>ACC	p.A52T		NM_016332	NP_057416	Q9NZV6	MSRB1_HUMAN	selenoprotein X, 1	52					protein repair	cytoplasm|nucleus	peptide-methionine-(S)-S-oxide reductase activity|zinc ion binding			ovary(1)	1					L-Methionine(DB00134)	ACGCTGTCGGCGTGAATGGTC	0.622													7	50					0	0	0	0	T	1991308	T	T	1991308	3	4	135	1	0	0	0	0	1	0	0	0	14138	768	27	1	208	1	SEPX1	16	1991308	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08		1991308	88363445	34	24028											
CYLD	1540	broad.mit.edu	37	chr16	50816274	50816274	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgaagtagtagaagaaaatActccaccaaaaatggaaaaa	22	6	8	5	0	0	3	0	1	0	2	1	4	1	4	2	1	1	2	2	1	11	3			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr16:50816274A>T	uc002egp.1	+	11	2138	c.1723A>T	c.(1723-1725)ACT>TCT	p.T575S	CYLD_uc002ego.2_Missense_Mutation_p.T572S|CYLD_uc010cbs.1_Missense_Mutation_p.T572S|CYLD_uc002egq.1_Missense_Mutation_p.T572S|CYLD_uc002egr.1_Missense_Mutation_p.T572S|CYLD_uc002egs.1_Missense_Mutation_p.T572S	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	575	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				AGAAGAAAATACTCCACCAAA	0.303			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				12	21					0	0	0	0	T	50816274	T	T	50816274	3	4	135	1	0	0	0	0	1	0	0	0	4160	391	14	5	1757	5	CYLD	16	50816274	Missense_Mutation	SNP	A	TCGA-CR-6493-01A-11D-1870-08	48824966	50816274	39538479	35	24029											
RLTPR	146206	broad.mit.edu	37	chr16	67680147	67680148	+	In_Frame_Ins	INS	-	CCTGGA	CCTGGA																															gagtttcctggtgtggccgcINScctggaacagctggcccagc																										TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr16:67680147_67680148insCCTGGA	uc002etn.2	+	5	428_429	c.308_309insCCTGGA	c.(307-309)GCC>GCCCTGGAC	p.103_104insLD	RLTPR_uc010cel.1_In_Frame_Ins_p.103_104insLD|RLTPR_uc010vjr.1_In_Frame_Ins_p.103_104insLD	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	103_104	LRR 2.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGTGTGGCCGCCCTGGAACAGC	0.639													---	---	---								CCTGGA	67680148	CCTGGA	CCTGGA	67680147	7	5	135	1	0	1	1	0	0	0	0	0	13459	739	26	0	326	0	RLTPR	16	67680147	In_Frame_Ins	INS	-	TCGA-CR-6493-01A-11D-1870-08	16863873	67680147	22674606	36	24030											
TP53	7157	broad.mit.edu	37	chr17	7577594	7577595	+	Frame_Shift_Del	DEL	AC	-	-																															tagttgtagtggatggtggtAcagtcagagccaacctagga																										TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr17:7577594_7577595delAC	uc002gim.2	-	7	880_881	c.686_687delGT	c.(685-687)TGTfs	p.C229fs	TP53_uc002gig.1_Frame_Shift_Del_p.C229fs|TP53_uc002gih.2_Frame_Shift_Del_p.C229fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.C97fs|TP53_uc010cng.1_Frame_Shift_Del_p.C97fs|TP53_uc002gii.1_Frame_Shift_Del_p.C97fs|TP53_uc010cnh.1_Frame_Shift_Del_p.C229fs|TP53_uc010cni.1_Frame_Shift_Del_p.C229fs|TP53_uc002gij.2_Frame_Shift_Del_p.C229fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.C136fs|TP53_uc002gio.2_Frame_Shift_Del_p.C97fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	229	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> Y (in sporadic cancers; somatic mutation).|C -> G (in a sporadic cancer; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C229fs*10(10)|p.0?(7)|p.C229*(3)|p.C229S(2)|p.C229R(2)|p.C229Y(2)|p.C229_H233delCTTIH(2)|p.T230fs*9(1)|p.C229fs*1(1)|p.C229fs*18(1)|p.C229_T230insX(1)|p.C229C(1)|p.V225fs*23(1)|p.D228fs*12(1)|p.C229G(1)|p.C229_I232del(1)|p.S227_I232delSDCTTI(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGATGGTGGTACAGTCAGAGCC	0.525		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7577595	-	-	7577594	7	5	135	1	0	1	0	1	0	0	0	0	16448	389	14	0	603	0	TP53	17	7577594	Frame_Shift_Del	DEL	AC	TCGA-CR-6493-01A-11D-1870-08		7577594	73617616	37	24031											
TP53	7157	broad.mit.edu	37	chr17	7578550	7578550	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acatcttgttgagggcagggGagtactgtaggaagaggaag	12	8	17	4	0	1	2	0	1	1	1	1	5	1	5	0	5	1	4	0	5	4	4			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr17:7578550G>T	uc002gim.2	-	5	574	c.380C>A	c.(379-381)TCC>TAC	p.S127Y	TP53_uc002gig.1_Missense_Mutation_p.S127Y|TP53_uc002gih.2_Missense_Mutation_p.S127Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.S127Y|TP53_uc010cni.1_Missense_Mutation_p.S127Y|TP53_uc002gij.2_Missense_Mutation_p.S127Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.S34Y|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.S88Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	127	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		S -> C (in a sporadic cancer; somatic mutation).|S -> F (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S127F(18)|p.S127Y(8)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.Y126_N131delYSPALN(3)|p.S127P(3)|p.S127T(2)|p.P128fs*42(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.P128fs*18(1)|p.Y126fs*11(1)|p.S127S(1)|p.S127C(1)|p.S127_Q136del10(1)|p.P13fs*18(1)|p.?(1)|p.S127fs*43(1)|p.S127fs*42(1)|p.Y126fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGGCAGGGGAGTACTGTAG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	29					1.01871e-10	1.0928e-10	1	0	T	7578550	T	T	7578550	3	4	135	1	0	0	0	0	1	0	0	0	16448	1174	41	2	918	2	TP53	17	7578550	Missense_Mutation	SNP	G	TCGA-CR-6493-01A-11D-1870-08	956	7578550	73616660	38	24032											
ARMC6	93436	broad.mit.edu	37	chr19	19162842	19162842	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgactggtgccatcaccCatcatggccaccacactgac	9	8	8	16	0	2	2	2	2	0	0	2	2	2	2	4	2	2	1	4	2	0	0			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr19:19162842C>T	uc002nld.2	+	5	1039	c.691C>T	c.(691-693)CAT>TAT	p.H231Y	ARMC6_uc002nlc.2_Missense_Mutation_p.H206Y|ARMC6_uc010xql.1_Missense_Mutation_p.H138Y|ARMC6_uc002nle.2_Missense_Mutation_p.H206Y|ARMC6_uc010xqm.1_Missense_Mutation_p.H231Y	NM_033415	NP_219483	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	231	ARM 1.						protein binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			TGCCATCACCCATCATGGCCA	0.592													7	44					0	0	0	0	T	19162842	T	T	19162842	3	4	135	1	0	0	0	0	1	0	0	0	957	594	21	4	626	4	ARMC6	19	19162842	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08		19162842	39966141	39	24033											
RYR1	6261	broad.mit.edu	37	chr19	38991629	38991629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagccgcctcgctggacaCggtgagcaaccctgcccagc	7	4	13	17	3	0	1	0	1	0	0	1	2	0	2	4	3	5	3	4	3	1	0			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr19:38991629C>T	uc002oit.2	+	47	7743	c.7613C>T	c.(7612-7614)ACG>ATG	p.T2538M	RYR1_uc002oiu.2_Missense_Mutation_p.T2538M|RYR1_uc002oiv.1_Translation_Start_Site	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2538	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCGCTGGACACGGTGAGCAAC	0.612													8	14					0	0	0	0	T	38991629	T	T	38991629	3	4	135	1	0	0	0	0	1	0	0	0	13833	550	19	1	7799	1	RYR1	19	38991629	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08	19828787	38991629	20137354	40	24034											
PREX1	57580	broad.mit.edu	37	chr20	47244457	47244457	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcagcaacccgtggctcCgtgccaagatggccgcctgc	6	6	14	15	3	0	1	0	0	0	1	1	1	1	1	5	3	4	3	5	3	2	0			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chr20:47244457C>T	uc002xtw.1	-	38	4834	c.4811G>A	c.(4810-4812)CGG>CAG	p.R1604Q	PREX1_uc002xtv.1_Missense_Mutation_p.R901Q	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1604					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCCGTGGCTCCGTGCCAAGAT	0.692													11	30					0	0	0	0	T	47244457	T	T	47244457	3	4	135	1	0	0	0	0	1	0	0	0	12538	652	23	1	180	1	PREX1	20	47244457	Missense_Mutation	SNP	C	TCGA-CR-6493-01A-11D-1870-08		47244457	15781063	41	24035											
FAM123B	139285	broad.mit.edu	37	chrX	63412939	63412939	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcccagaacctttgctccgTccccctccaaagaaactagg	10	9	6	16	1	0	2	0	0	0	2	4	2	4	2	6	1	3	1	6	1	4	3			TCGA-CR-6493-01A-11D-1870-08	TCGA-CR-6493-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	f061abfa-4554-4328-9e8f-b84dd2aa4b45	b8689030-bf4c-4d70-a563-b974838c6bd1	g.chrX:63412939T>C	uc004dvo.2	-	2	501	c.228A>G	c.(226-228)GGA>GGG	p.G76G		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	76					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CTTTGCTCCGTCCCCCTCCAA	0.537													3	74					0	0	0	0	C	63412939	C	C	63412939	2	2	135	1	0	0	0	0	0	0	0	1	5451	1654	58	5		5	FAM123B	23	63412939	Silent	SNP	T	TCGA-CR-6493-01A-11D-1870-08		63412939	91857621	42	24036											
SPATA21	374955	broad.mit.edu	37	chr1	16736455	16736455	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgccggaagttcccgaggctCtgtgtccctgcagccaccgc	5	8	12	16	3	1	0	0	0	1	0	3	2	3	1	5	2	3	3	5	2	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:16736455C>G	uc001ayn.2	-	6	711	c.228G>C	c.(226-228)CAG>CAC	p.Q76H	SPATA21_uc001ayl.1_RNA|SPATA21_uc010occ.1_Missense_Mutation_p.Q53H	NM_198546	NP_940948	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	76							calcium ion binding			ovary(2)|breast(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		TCCCGAGGCTCTGTGTCCCTG	0.657													24	63					0	0	0	0	G	16736455	G	G	16736455	3	3	136	1	0	0	0	0	1	0	0	0	15073	912	32	2	1213	2	SPATA21	1	16736455	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08		16736455	232514166	1	24037											
NBPF1	55672	broad.mit.edu	37	chr1	16914293	16914293	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctcatcttcgtcattttCtgtaaatacaaaatgttcgt	11	17	4	9	2	4	0	2	0	2	0	7	0	5	0	1	0	1	2	1	0	5	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:16914293C>A	uc009vos.1	-	10	1382	c.494_splice	c.e10-1	p.E165_splice	NBPF1_uc009vot.1_5'Flank|NBPF1_uc001ayz.1_5'Flank|NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCGTCATTTTCTGTAAATACA	0.428													31	491					1.66251e-12	2.20952e-12	1	0	A	16914293	A	A	16914293	5	1	136	1	0	0	0	0	0	0	1	0	10245	927	32	2	3011	2	NBPF1	1	16914293	Splice_Site	SNP	C	TCGA-CR-7364-01A-11D-2012-08	177838	16914293	232336328	2	24038											
KLHDC7A	127707	broad.mit.edu	37	chr1	18809211	18809211	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgcccgctgaaccaggcccGgccgcactgccggctggtgg	4	5	16	16	4	0	1	0	1	0	0	0	1	0	1	5	5	3	3	5	5	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:18809211G>T	uc001bax.2	+	1	1788	c.1736G>T	c.(1735-1737)CGG>CTG	p.R579L	KLHDC7A_uc009vpg.2_Missense_Mutation_p.R361L	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	579	Kelch 3.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		AACCAGGCCCGGCCGCACTGC	0.711													9	21					7.48243e-07	8.85851e-07	1	0	T	18809211	T	T	18809211	3	4	136	1	0	0	0	0	1	0	0	0	8399	1116	39	3	1738	3	KLHDC7A	1	18809211	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1894918	18809211	230441410	3	24039											
AIM1L	55057	broad.mit.edu	37	chr1	26648778	26648778	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caccttggagcctgggctagGgggtccaatcacctgtaggc	7	8	14	12	0	1	0	1	0	0	0	2	1	2	1	4	5	1	2	4	5	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:26648778G>A	uc001bmd.3	-	18	2069	c.1639C>T	c.(1639-1641)CCT>TCT	p.P547S		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	547	Ricin B-type lectin.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		CCTGGGCTAGGGGGTCCAATC	0.617													24	65					0	0	0	0	A	26648778	A	A	26648778	3	1	136	1	0	0	0	0	1	0	0	0	431	1232	43	4	219	4	AIM1L	1	26648778	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	7839567	26648778	222601843	4	24040											
PTPRU	10076	broad.mit.edu	37	chr1	29611279	29611279	+	Frame_Shift_Del	DEL	C	-	-																															caagcggcccctggaggtgtCccagagatcggaggagatgg																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:29611279delC	uc001bru.2	+	14	2326	c.2216delC	c.(2215-2217)TCCfs	p.S739fs	PTPRU_uc001brv.2_Frame_Shift_Del_p.S739fs|PTPRU_uc001brw.2_Frame_Shift_Del_p.S739fs|PTPRU_uc009vtq.2_Frame_Shift_Del_p.S739fs|PTPRU_uc009vtr.2_Frame_Shift_Del_p.S739fs	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	739	Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CTGGAGGTGTCCCAGAGATCG	0.577													---	---	---								-	29611279	-	-	29611279	7	5	136	1	0	1	0	1	0	0	0	0	12878	855	30	0	2270	0	PTPRU	1	29611279	Frame_Shift_Del	DEL	C	TCGA-CR-7364-01A-11D-2012-08	2962501	29611279	219639342	5	24041											
KIAA1522	57648	broad.mit.edu	37	chr1	33237601	33237601	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgactcaaggcctgcagcCtggccgccagtgaaggcctc	7	6	12	16	2	1	1	1	1	0	0	3	2	2	1	6	3	2	1	6	3	2	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:33237601C>G	uc001bvv.2	+	6	2780	c.2644C>G	c.(2644-2646)CTG>GTG	p.L882V	KIAA1522_uc001bvu.1_Missense_Mutation_p.L941V|KIAA1522_uc010ohm.1_Missense_Mutation_p.L893V|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	882	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GGCCTGCAGCCTGGCCGCCAG	0.682													4	36					0	0	0	0	G	33237601	G	G	33237601	3	3	136	1	0	0	0	0	1	0	0	0	8277	680	24	4	2843	4	KIAA1522	1	33237601	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3626322	33237601	216013020	6	24042											
C1orf94	84970	broad.mit.edu	37	chr1	34666433	34666433	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcctctttctcagccagtGgccccagagccagaaggacg	9	6	12	14	1	2	2	1	0	2	2	3	4	2	3	5	2	3	0	5	2	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:34666433G>T	uc001bxs.3	+	3	899	c.500G>T	c.(499-501)TGG>TTG	p.W167L	C1orf94_uc001bxt.2_Missense_Mutation_p.W357L	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	167							protein binding				0		Myeloproliferative disorder(586;0.0393)				CTCAGCCAGTGGCCCCAGAGC	0.587													38	65					3.09479e-21	4.56463e-21	1	0	T	34666433	T	T	34666433	3	4	136	1	0	0	0	0	1	0	0	0	2081	1357	47	4	1080	4	C1orf94	1	34666433	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1428832	34666433	214584188	7	24043											
EIF2C4	192670	broad.mit.edu	37	chr1	36298098	36298098	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcgaggaaagcagttttatGctggcattgaaattaaagtt	13	13	11	4	1	0	1	0	1	0	0	0	3	0	2	0	2	3	5	0	2	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:36298098G>T	uc001bzj.1	+	11	1496	c.1306G>T	c.(1306-1308)GCT>TCT	p.A436S		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	436					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCAGTTTTATGCTGGCATTGA	0.333													23	55					1.50039e-11	1.96449e-11	1	0	T	36298098	T	T	36298098	3	4	136	1	0	0	0	0	1	0	0	0	5030	1319	46	4	1348	4	EIF2C4	1	36298098	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1631665	36298098	212952523	8	24044											
PTCH2	8643	broad.mit.edu	37	chr1	45294273	45294273	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtgagtacgacactggtgcCcgtgcgctgcagacactcgc	7	8	13	13	4	0	2	0	1	0	1	1	3	0	2	1	1	4	3	1	1	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:45294273C>G	uc010olf.1	-	12	1507	c.1495G>C	c.(1495-1497)GGC>CGC	p.G499R	PTCH2_uc010olg.1_Missense_Mutation_p.G197R	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	499	SSD.|Cytoplasmic (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					ACACTGGTGCCCGTGCGCTGC	0.632									Basal_Cell_Nevus_syndrome				5	14					0	0	0	0	G	45294273	G	G	45294273	3	3	136	1	0	0	0	0	1	0	0	0	12793	623	22	4	2180	4	PTCH2	1	45294273	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	8996175	45294273	203956348	9	24045											
RAD54L	8438	broad.mit.edu	37	chr1	46726971	46726971	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtggagccagggtgtcttctCccatcctcatcatttcctat	6	14	8	13	0	4	0	2	0	2	0	7	1	6	1	4	2	1	0	4	2	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:46726971C>A	uc009vye.2	+	9	919	c.805C>A	c.(805-807)CCC>ACC	p.P269T	RAD54L_uc001cpl.2_Missense_Mutation_p.P269T|RAD54L_uc001cpm.1_Missense_Mutation_p.P89T	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	269	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		GGTGTCTTCTCCCATCCTCAT	0.423								Direct_reversal_of_damage|Homologous_recombination					20	44					0.00152264	0.00166253	1	0	A	46726971	A	A	46726971	3	1	136	1	0	0	0	0	1	0	0	0	13058	855	30	2	835	2	RAD54L	1	46726971	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1432698	46726971	202523650	10	24046											
USP24	23358	broad.mit.edu	37	chr1	55545229	55545229	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acctctaacaggtaaggtttCccttcagacatgaacaacaa	15	9	6	11	0	2	2	1	1	1	1	3	2	3	2	2	2	3	2	2	2	5	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:55545229C>A	uc001cyg.3	-	57	6702	c.6702G>T	c.(6700-6702)GGG>GGT	p.G2234G		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	2394					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						GGTAAGGTTTCCCTTCAGACA	0.433													31	113					7.11191e-15	9.76702e-15	1	0	A	55545229	A	A	55545229	2	1	136	1	0	0	0	0	0	0	0	1	17123	842	30	2		2	USP24	1	55545229	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	8818258	55545229	193705392	11	24047											
C8B	732	broad.mit.edu	37	chr1	57420405	57420405	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtattggtccatttcatgctGacattttttataaatccttc	9	19	5	8	0	1	1	1	1	0	0	4	1	3	1	2	1	1	2	2	1	4	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:57420405G>A	uc001cyp.2	-	4	554	c.487C>T	c.(487-489)CAG>TAG	p.Q163*	C8B_uc010oon.1_Nonsense_Mutation_p.Q101*|C8B_uc010ooo.1_Nonsense_Mutation_p.Q111*	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	163	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						ATTTCATGCTGACATTTTTTA	0.443													25	72					0	0	0	0	A	57420405	A	A	57420405	4	1	136	1	0	0	0	0	0	1	0	0	2428	1299	45	2	1324	2	C8B	1	57420405	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1875176	57420405	191830216	12	24048											
RAVER2	55225	broad.mit.edu	37	chr1	65278490	65278490	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcggctcagtaaaaatccaTacttgaatttggcaagtgtg	12	13	9	7	1	1	1	1	1	0	0	3	1	2	1	1	2	1	3	1	2	6	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:65278490T>C	uc001dbs.1	+	10	1789	c.1711T>C	c.(1711-1713)TAC>CAC	p.Y571H	RAVER2_uc001dbt.1_Missense_Mutation_p.Y463H|RAVER2_uc010opb.1_Missense_Mutation_p.Y296H	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	584						cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						TAAAAATCCATACTTGAATTT	0.383													8	33					0	0	0	0	C	65278490	C	C	65278490	3	2	136	1	0	0	0	0	1	0	0	0	13160	1406	49	5	1749	5	RAVER2	1	65278490	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	7858085	65278490	183972131	13	24049											
WLS	79971	broad.mit.edu	37	chr1	68613868	68613868	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatactgtagaagggattcGtgagttgtacccctctacaa	12	11	10	8	1	1	3	0	1	1	2	2	4	1	4	2	1	3	3	2	1	6	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:68613868G>A	uc001def.1	-	8	1356	c.1085C>T	c.(1084-1086)ACG>ATG	p.T362M	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Missense_Mutation_p.T360M|WLS_uc001deg.1_Missense_Mutation_p.T271M|WLS_uc009wbf.1_Missense_Mutation_p.T317M	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	362	Lumenal (Potential).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						GAAGGGATTCGTGAGTTGTAC	0.443													21	75					0	0	0	0	A	68613868	A	A	68613868	3	1	136	1	0	0	0	0	1	0	0	0	17444	1145	40	1	686	1	WLS	1	68613868	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	3335378	68613868	180636753	14	24050											
C1orf173	127254	broad.mit.edu	37	chr1	75072489	75072489	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctctctttcctcactttccCctcagccttcttcagttcct	3	18	2	18	0	6	0	3	0	3	0	10	0	9	0	5	0	1	1	5	0	0	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:75072489C>A	uc001dgg.2	-	10	1504	c.1285G>T	c.(1285-1287)GGG>TGG	p.G429W	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.G223W	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	429	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTCACTTTCCCCTCAGCCTTC	0.403													44	107					2.24893e-16	3.16592e-16	1	0	A	75072489	A	A	75072489	3	1	136	1	0	0	0	0	1	0	0	0	2023	623	22	4	3327	4	C1orf173	1	75072489	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	6458621	75072489	174178132	15	24051											
MSH4	4438	broad.mit.edu	37	chr1	76343943	76343943	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctatgcagtgaggtctaacAtaaatgaatttcttgacata	14	13	8	6	0	2	3	0	3	2	0	2	3	2	3	0	1	2	2	0	1	6	6	rs116549128	byFrequency	TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:76343943A>G	uc001dhd.1	+	11	1521	c.1480A>G	c.(1480-1482)ATA>GTA	p.I494V		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	494					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						GAGGTCTAACATAAATGAATT	0.318								MMR					11	24					0	0	0	0	G	76343943	G	G	76343943	3	3	136	1	0	0	0	0	1	0	0	0	9925	217	8	5	1522	5	MSH4	1	76343943	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	1271454	76343943	172906678	16	24052											
ST6GALNAC3	256435	broad.mit.edu	37	chr1	76877998	76877998	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcatcgtttacaacatgttGaaaaagacagttggtatcta	14	12	9	6	1	1	2	0	1	1	1	2	2	1	2	0	2	2	5	0	2	6	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:76877998G>A	uc001dhh.2	+	3	682	c.519G>A	c.(517-519)TTG>TTA	p.L173L	ST6GALNAC3_uc001dhg.3_Silent_p.L173L|ST6GALNAC3_uc010orh.1_Silent_p.L108L	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	173	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						ACAACATGTTGAAAAAGACAG	0.393													19	68					0	0	0	0	A	76877998	A	A	76877998	2	1	136	1	0	0	0	0	0	0	0	1	15291	1281	45	2		2	ST6GALNAC3	1	76877998	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	534055	76877998	172372623	17	24053											
AK5	26289	broad.mit.edu	37	chr1	77763626	77763626	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccaggctctatcttttgaGgaccaagtaagaatatctcc	11	11	8	11	0	3	2	0	1	3	1	4	3	3	3	3	2	0	2	3	2	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:77763626G>A	uc001dhn.2	+	5	950	c.693G>A	c.(691-693)GAG>GAA	p.E231E	AK5_uc001dho.2_Silent_p.E205E|AK5_uc001dhm.1_Silent_p.E207E	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	231					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						TATCTTTTGAGGACCAAGTAA	0.333													7	28					0	0	0	0	A	77763626	A	A	77763626	2	1	136	1	0	0	0	0	0	0	0	1	443	991	35	4		4	AK5	1	77763626	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	885628	77763626	171486995	18	24054											
HFM1	164045	broad.mit.edu	37	chr1	91846506	91846506	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actgtatatagttgaaatatGgaaattctttgaaaatactt	16	16	6	3	0	1	2	0	2	1	0	1	3	1	3	0	1	1	2	0	1	9	9			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:91846506G>T	uc001doa.3	-	7	936	c.836C>A	c.(835-837)CCA>CAA	p.P279Q	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.P279Q	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	279							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GTTGAAATATGGAAATTCTTT	0.179													7	41					2.17888e-05	2.47983e-05	1	0	T	91846506	T	T	91846506	3	4	136	1	0	0	0	0	1	0	0	0	7122	1348	47	4	3603	4	HFM1	1	91846506	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	14082880	91846506	157404115	19	24055											
STXBP3	6814	broad.mit.edu	37	chr1	109315300	109315300	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacttaggtgtatactcttgAtgtaccagatgcattctatt	11	16	7	7	0	2	2	0	1	2	1	2	2	2	2	1	1	4	3	1	1	6	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:109315300A>G	uc001dvy.2	+	7	527	c.452A>G	c.(451-453)GAT>GGT	p.D151G	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	151	Mediates interaction with DOC2B (By similarity).				negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TATACTCTTGATGTACCAGAT	0.308													11	25					0	0	0	0	G	109315300	G	G	109315300	3	3	136	1	0	0	0	0	1	0	0	0	15420	333	12	5	478	5	STXBP3	1	109315300	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	17468794	109315300	139935321	20	24056											
KCNA10	3744	broad.mit.edu	37	chr1	111060380	111060380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcggaagaccctcaccaggcGgatgatcctcaggatggcca	10	5	13	13	2	2	2	2	1	0	1	3	5	3	5	4	5	0	0	4	5	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:111060380G>A	uc001dzt.1	-	1	1418	c.1030C>T	c.(1030-1032)CGC>TGC	p.R344C		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	344	Helical; Voltage-sensor; Name=Segment S4; (Potential).					voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		CTCACCAGGCGGATGATCCTC	0.577													45	120					0	0	0	0	A	111060380	A	A	111060380	3	1	136	1	0	0	0	0	1	0	0	0	8041	1116	39	1	509	1	KCNA10	1	111060380	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1745080	111060380	138190241	21	24057											
KCNA3	3738	broad.mit.edu	37	chr1	111216792	111216792	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacctggcgctggaagtcgcGgcggggcaagggccgctcct	5	5	17	14	5	0	0	0	0	0	0	2	1	1	1	3	6	0	3	3	6	2	0	rs145190352	byFrequency	TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:111216792G>A	uc001dzv.1	-	1	864	c.640C>T	c.(640-642)CGC>TGC	p.R214C		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	214						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGAAGTCGCGGCGGGGCAAG	0.687													31	71					0	0	0	0	A	111216792	A	A	111216792	3	1	136	1	0	0	0	0	1	0	0	0	8043	1116	39	1	1091	1	KCNA3	1	111216792	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	156412	111216792	138033829	22	24058											
PTPN22	26191	broad.mit.edu	37	chr1	114397155	114397155	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaccagtccttccacagcCagcactgaaatgaaagatca	16	6	6	13	0	1	3	1	2	0	1	3	3	3	3	4	0	3	1	4	0	3	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:114397155C>T	uc001eds.2	-	9	818	c.688G>A	c.(688-690)GGC>AGC	p.G230S	uc001edv.1_5'Flank|PTPN22_uc009wgq.2_Missense_Mutation_p.G230S|PTPN22_uc010owo.1_5'UTR|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.G230S|PTPN22_uc009wgs.2_Intron|PTPN22_uc001edu.2_Missense_Mutation_p.G230S	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	230	Substrate binding.|Tyrosine-protein phosphatase.				negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCCACAGCCAGCACTGAAA	0.418													6	29					0	0	0	0	T	114397155	T	T	114397155	3	4	136	1	0	0	0	0	1	0	0	0	12852	594	21	4	1810	4	PTPN22	1	114397155	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3180363	114397155	134853466	23	24059											
PTGFRN	5738	broad.mit.edu	37	chr1	117487467	117487467	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcggcccggccaggcggagCgtcctcgccctgacccacga	5	3	14	19	7	0	1	0	1	0	0	2	3	1	2	5	4	1	0	5	4	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:117487467C>T	uc001egv.1	+	3	722	c.585C>T	c.(583-585)AGC>AGT	p.S195S		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	195	Ig-like C2-type 2.|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		CCAGGCGGAGCGTCCTCGCCC	0.751													4	11					0	0	0	0	T	117487467	T	T	117487467	2	4	136	1	0	0	0	0	0	0	0	1	12813	767	27	1		1	PTGFRN	1	117487467	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3090312	117487467	131763154	24	24060											
CD101	9398	broad.mit.edu	37	chr1	117560848	117560848	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accaacacctttgacctgtcCtgtgtcgtgagggccggtta	7	11	11	12	2	0	2	0	2	0	0	2	2	1	2	5	2	1	1	5	2	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:117560848C>T	uc010oxb.1	+	6	1741	c.1683C>T	c.(1681-1683)TCC>TCT	p.S561S	CD101_uc009whd.2_Silent_p.S561S|CD101_uc010oxc.1_Silent_p.S561S|CD101_uc010oxd.1_Silent_p.S499S	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	561	Extracellular (Potential).|Ig-like C2-type 5.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TTGACCTGTCCTGTGTCGTGA	0.478													6	37					0	0	0	0	T	117560848	T	T	117560848	2	4	136	1	0	0	0	0	0	0	0	1	2977	668	24	4		4	CD101	1	117560848	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	73381	117560848	131689773	25	24061											
FAM46C	54855	broad.mit.edu	37	chr1	118165682	118165682	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggctggaggaggcaggcatCaaagtgcacgacgtccggct	9	5	16	11	4	1	0	1	0	0	0	2	3	2	2	1	6	1	5	1	6	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:118165682C>T	uc001ehe.2	+	2	391	c.192C>T	c.(190-192)ATC>ATT	p.I64I		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	64											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		AGGCAGGCATCAAAGTGCACG	0.552										Multiple Myeloma(3;1.13e-06)			30	80					0	0	0	0	T	118165682	T	T	118165682	2	4	136	1	0	0	0	0	0	0	0	1	5599	816	29	2		2	FAM46C	1	118165682	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	604834	118165682	131084939	26	24062											
SPAG17	200162	broad.mit.edu	37	chr1	118624066	118624066	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttggcctcttgagtattCattttcatgacatattgctg	7	18	8	8	0	3	2	2	2	1	0	3	2	3	2	1	1	2	3	1	1	2	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:118624066C>G	uc001ehk.2	-	14	2030	c.1962G>C	c.(1960-1962)ATG>ATC	p.M654I		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	654						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTTGAGTATTCATTTTCATGA	0.408													20	75					0	0	0	0	G	118624066	G	G	118624066	3	3	136	1	0	0	0	0	1	0	0	0	15045	826	29	2	4849	2	SPAG17	1	118624066	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	458384	118624066	130626555	27	24063											
ACP6	51205	broad.mit.edu	37	chr1	147119326	147119326	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	catggcattcaagaacatgtCcagcgggcagagcccatcag	12	6	11	12	1	2	2	2	0	0	2	3	2	3	2	2	2	3	2	2	2	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:147119326C>G	uc001epr.2	-	10	1650	c.1186G>C	c.(1186-1188)GAC>CAC	p.D396H		NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	396					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					AAGAACATGTCCAGCGGGCAG	0.502													22	46					0	0	0	0	G	147119326	G	G	147119326	3	3	136	1	0	0	0	0	1	0	0	0	165	855	30	2	104	2	ACP6	1	147119326	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	28495260	147119326	102131295	28	24064											
TTC24	164118	broad.mit.edu	37	chr1	156554971	156554971	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagggccaccagaagaaaaaAgaggagaggtcggcaaacgt	17	2	15	7	2	0	4	0	0	0	4	1	6	0	4	2	4	1	1	2	4	5	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:156554971A>G	uc009wsc.1	+	6	704	c.564A>G	c.(562-564)AAA>AAG	p.K188K		NM_001105669	NP_001099139	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	468							binding			pancreas(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGAAGAAAAAAGAGGAGAGGT	0.562													18	37					0	0	0	0	G	156554971	G	G	156554971	2	3	136	1	0	0	0	0	0	0	0	1	16760	69	3	5		5	TTC24	1	156554971	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	9435645	156554971	92695650	29	24065											
FCRL4	83417	broad.mit.edu	37	chr1	157555966	157555966	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attaaaactcacctctcacaGtgacattcagcaccatgctc	13	10	4	14	0	3	1	3	1	1	0	5	1	3	1	2	0	3	2	2	0	2	2	rs150996859		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:157555966G>T	uc001fqw.2	-	6	1263	c.1127C>A	c.(1126-1128)ACT>AAT	p.T376N	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	376	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				ACCTCTCACAGTGACATTCAG	0.388													40	85					3.09479e-21	4.56463e-21	1	0	T	157555966	T	T	157555966	3	4	136	1	0	0	0	0	1	0	0	0	5829	1029	36	4	448	4	FCRL4	1	157555966	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1000995	157555966	91694655	30	24066											
CD1D	912	broad.mit.edu	37	chr1	158151871	158151871	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgaggtgcaccctgggaaCgcctcaaataacttcttcca	10	10	9	12	1	2	1	1	1	1	0	3	2	3	2	3	2	3	1	3	2	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:158151871C>T	uc001frr.2	+	4	877	c.378C>T	c.(376-378)AAC>AAT	p.N126N	CD1D_uc009wsr.1_Silent_p.N126N|CD1D_uc009wss.2_Silent_p.N126N|CD1D_uc009wst.1_Silent_p.N22N	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	126	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					ACCCTGGGAACGCCTCAAATA	0.493													55	169					0	0	0	0	T	158151871	T	T	158151871	2	4	136	1	0	0	0	0	0	0	0	1	2992	535	19	1		1	CD1D	1	158151871	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	595905	158151871	91098750	31	24067											
SELP	6403	broad.mit.edu	37	chr1	169582838	169582838	+	Frame_Shift_Del	DEL	G	-	-																															cctcaccgtattcacattctGgcccatagaatccagggtaa																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:169582838delG	uc001ggi.3	-	4	640	c.575delC	c.(574-576)CCAfs	p.P192fs	SELP_uc001ggh.2_Frame_Shift_Del_p.P27fs|SELP_uc009wvr.2_Frame_Shift_Del_p.P192fs	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	192	Extracellular (Potential).|EGF-like.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TTCACATTCTGGCCCATAGAA	0.453													---	---	---								-	169582838	-	-	169582838	7	5	136	1	0	1	0	1	0	0	0	0	14084	1348	47	0	1969	0	SELP	1	169582838	Frame_Shift_Del	DEL	G	TCGA-CR-7364-01A-11D-2012-08	11430967	169582838	79667783	32	24068											
SELE	6401	broad.mit.edu	37	chr1	169696913	169696913	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aacctcttctgtccattgtcCctgagatgtgcactcaagtt	8	14	7	12	0	3	1	1	1	2	1	5	2	5	1	3	0	2	2	3	0	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:169696913C>A	uc001ggm.3	-	9	1592	c.1435G>T	c.(1435-1437)GGA>TGA	p.G479*	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	479	Extracellular (Potential).|Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GTCCATTGTCCCTGAGATGTG	0.428													31	99					9.65021e-13	1.28808e-12	1	0	A	169696913	A	A	169696913	4	1	136	1	0	0	0	0	0	1	0	0	14078	632	22	4	417	4	SELE	1	169696913	Nonsense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	114075	169696913	79553708	33	24069											
ASTN1	460	broad.mit.edu	37	chr1	176903411	176903411	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtaatggttgccgaactggtCcaacagcgccacaaaatctg	12	8	10	11	2	1	0	0	0	1	0	2	1	2	0	3	2	4	2	3	2	5	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:176903411C>A	uc001glc.2	-	16	2760	c.2548G>T	c.(2548-2550)GAC>TAC	p.D850Y	ASTN1_uc001glb.1_Missense_Mutation_p.D850Y|ASTN1_uc001gld.1_Missense_Mutation_p.D850Y	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	858					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CCGAACTGGTCCAACAGCGCC	0.542													26	52					7.33532e-06	8.41044e-06	1	0	A	176903411	A	A	176903411	3	1	136	1	0	0	0	0	1	0	0	0	1066	855	30	2	1372	2	ASTN1	1	176903411	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	7206498	176903411	72347210	34	24070											
TPR	7175	broad.mit.edu	37	chr1	186337063	186337063	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagtctctcattggttctaaTtaagtctcttttctcagctt	7	20	5	9	0	5	0	2	0	4	0	8	0	5	0	0	1	1	2	0	1	3	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:186337063T>C	uc001grv.2	-	4	679	c.382A>G	c.(382-384)ATT>GTT	p.I128V	TPR_uc010pop.1_Missense_Mutation_p.I204V	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	128	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTGGTTCTAATTAAGTCTCTT	0.323			T	NTRK1	papillary thyroid								10	20					0	0	0	0	C	186337063	C	C	186337063	3	2	136	1	0	0	0	0	1	0	0	0	16483	1493	52	5	6901	5	TPR	1	186337063	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	9433652	186337063	62913558	35	24071											
ASPM	259266	broad.mit.edu	37	chr1	197070947	197070947	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgcagccctttgcatttcTtgtaacttcttctttaccat	7	18	4	12	0	3	0	0	0	3	0	3	0	3	0	2	0	5	3	2	0	2	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:197070947T>C	uc001gtu.2	-	18	7691	c.7434A>G	c.(7432-7434)CAA>CAG	p.Q2478Q	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Silent_p.Q326Q	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2478	IQ 26.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTTGCATTTCTTGTAACTTCT	0.363													23	88					0	0	0	0	C	197070947	C	C	197070947	2	2	136	1	0	0	0	0	0	0	0	1	1058	1606	56	5		5	ASPM	1	197070947	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	10733884	197070947	52179674	36	24072											
CRB1	23418	broad.mit.edu	37	chr1	197397023	197397023	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgtatccaagatgtaagActaaacaaccaaaatctgga	17	8	8	8	0	1	2	0	0	1	2	2	3	2	3	2	2	2	3	2	2	8	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:197397023A>T	uc001gtz.2	+	7	2703	c.2568A>T	c.(2566-2568)AGA>AGT	p.R856S	CRB1_uc010poz.1_Missense_Mutation_p.R787S|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.R744S|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.R337S|CRB1_uc001gub.1_Missense_Mutation_p.R505S	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	856	Extracellular (Potential).|Laminin G-like 2.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AAGATGTAAGACTAAACAACC	0.408													9	20					0	0	0	0	T	197397023	T	T	197397023	3	4	136	1	0	0	0	0	1	0	0	0	3863	272	10	5	2594	5	CRB1	1	197397023	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	326076	197397023	51853598	37	24073											
LHX9	56956	broad.mit.edu	37	chr1	197896918	197896918	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggtctgaccaaaagagttTtgcaggtaagacacatgcat	14	9	10	8	0	1	3	0	1	1	2	1	3	1	3	1	2	2	4	1	2	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:197896918T>C	uc001guk.1	+	4	1368	c.931T>C	c.(931-933)TTG>CTG	p.L311L	LHX9_uc001gui.1_Silent_p.L302L|LHX9_uc001guj.1_Silent_p.L317L	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	311	Homeobox.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						CAAAAGAGTTTTGCAGGTAAG	0.483													17	63					0	0	0	0	C	197896918	C	C	197896918	2	2	136	1	0	0	0	0	0	0	0	1	8818	1838	64	5		5	LHX9	1	197896918	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	499895	197896918	51353703	38	24074											
PRELP	5549	broad.mit.edu	37	chr1	203453274	203453274	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acacctgtacctcaacaacaAtagcatcgagagtgagtggg	14	7	10	10	1	1	2	1	1	0	1	2	3	1	2	2	1	4	2	2	1	5	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:203453274A>G	uc001gzs.2	+	2	1162	c.962A>G	c.(961-963)AAT>AGT	p.N321S	PRELP_uc001gzt.2_Missense_Mutation_p.N321S	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	321	LRR 10.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			CTCAACAACAATAGCATCGAG	0.572													15	36					0	0	0	0	G	203453274	G	G	203453274	3	3	136	1	0	0	0	0	1	0	0	0	12535	101	4	5	964	5	PRELP	1	203453274	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	5556356	203453274	45797347	39	24075											
REN	5972	broad.mit.edu	37	chr1	204130517	204130517	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaggtctggggtggggtgccGatgccaatctcgccatagta	8	9	15	9	2	2	0	0	0	2	0	3	1	2	0	3	5	2	1	3	5	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:204130517G>A	uc001haq.2	-	3	320	c.276C>T	c.(274-276)ATC>ATT	p.I92I		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	92					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GTGGGGTGCCGATGCCAATCT	0.582													6	24					0	0	0	0	A	204130517	A	A	204130517	2	1	136	1	0	0	0	0	0	0	0	1	13289	1048	37	1		1	REN	1	204130517	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	677243	204130517	45120104	40	24076											
KISS1	3814	broad.mit.edu	37	chr1	204159795	204159795	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccggctgctgggggctcccGgagctctcggggggcgggga	2	5	21	13	4	1	0	0	0	1	0	3	2	2	2	2	9	2	4	2	9	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:204159795G>T	uc001har.2	-	3	388	c.234C>A	c.(232-234)TCC>TCA	p.S78S		NM_002256	NP_002247	Q15726	KISS1_HUMAN	KiSS-1 metastasis-suppressor	78					cytoskeleton organization	extracellular region	protein binding			ovary(1)	1	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)	Breast(1374;9.42e-05)	KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.069)|Kidney(21;0.0934)|Epithelial(59;0.239)	Colorectal(1306;0.0129)		GGGGGCTCCCGGAGCTCTCGG	0.751													5	13					1.024e-07	1.24085e-07	1	0	T	204159795	T	T	204159795	2	4	136	1	0	0	0	0	0	0	0	1	8366	1103	39	3		3	KISS1	1	204159795	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	29278	204159795	45090826	41	24077											
KLHDC8A	55220	broad.mit.edu	37	chr1	205308834	205308834	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	catatctcggggtgggcatgGgtgctagggacacccacatg	8	8	15	10	1	1	0	0	0	1	0	2	1	1	1	1	5	1	2	1	5	2	2	rs17853535		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:205308834G>A	uc001hcf.1	-	3	1047	c.479C>T	c.(478-480)CCC>CTC	p.P160L	KLHDC8A_uc010prg.1_Missense_Mutation_p.P47L|KLHDC8A_uc001hcg.1_Missense_Mutation_p.P160L	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	160	Kelch 4.			P -> H (in Ref. 4; AAH36076).						ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GGTGGGCATGGGTGCTAGGGA	0.567													12	50					0	0	0	0	A	205308834	A	A	205308834	3	1	136	1	0	0	0	0	1	0	0	0	8401	1232	43	4	589	4	KLHDC8A	1	205308834	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1149039	205308834	43941787	42	24078											
PM20D1	148811	broad.mit.edu	37	chr1	205797807	205797807	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcagcattctgaatcaactCaaagatgaatttcacttggg	13	12	8	8	0	5	3	4	2	1	1	5	3	5	3	0	1	2	1	0	1	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:205797807C>G	uc001hdj.2	-	13	1495	c.1450G>C	c.(1450-1452)GAG>CAG	p.E484Q	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	484						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			TGAATCAACTCAAAGATGAAT	0.512													23	41					0	0	0	0	G	205797807	G	G	205797807	3	3	136	1	0	0	0	0	1	0	0	0	12183	835	29	2	62	2	PM20D1	1	205797807	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	488973	205797807	43452814	43	24079											
PLXNA2	5362	broad.mit.edu	37	chr1	208224624	208224624	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcaatgctccactctggctcGatgcgctggacccgagggtc	6	8	13	14	3	1	0	0	0	1	0	4	3	2	1	2	3	2	4	2	3	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:208224624G>C	uc001hgz.2	-	16	3896	c.3138C>G	c.(3136-3138)ATC>ATG	p.I1046M		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1046	Extracellular (Potential).|IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ACTCTGGCTCGATGCGCTGGA	0.592													9	38					0	0	0	0	C	208224624	C	C	208224624	3	2	136	1	0	0	0	0	1	0	0	0	12175	1048	37	3	2614	3	PLXNA2	1	208224624	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2426817	208224624	41025997	44	24080											
SERTAD4	56256	broad.mit.edu	37	chr1	210415652	210415652	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcttcaccaccaagtaacaaActgtgctgcagcaaaggaag	15	6	9	11	0	1	0	1	0	0	0	1	1	1	1	2	1	5	5	2	1	5	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:210415652A>G	uc001hhy.2	+	4	1220	c.1041A>G	c.(1039-1041)AAA>AAG	p.K347K	SERTAD4_uc009xcw.2_Silent_p.K347K	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	347							protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		CAAGTAACAAACTGTGCTGCA	0.358													10	34					0	0	0	0	G	210415652	G	G	210415652	2	3	136	1	0	0	0	0	0	0	0	1	14188	40	2	5		5	SERTAD4	1	210415652	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	2191028	210415652	38834969	45	24081											
USH2A	7399	broad.mit.edu	37	chr1	215990367	215990367	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagaagaatagcaaatgtgtCcacagatagattcaggtttt	15	11	9	6	0	1	4	1	0	0	4	2	4	2	4	1	1	1	2	1	1	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:215990367C>T	uc001hku.1	-	48	9929	c.9542G>A	c.(9541-9543)GGA>GAA	p.G3181E		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3181	Extracellular (Potential).|Fibronectin type-III 18.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCAAATGTGTCCACAGATAGA	0.388										HNSCC(13;0.011)			20	65					0	0	0	0	T	215990367	T	T	215990367	3	4	136	1	0	0	0	0	1	0	0	0	17104	855	30	2	6166	2	USH2A	1	215990367	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5574715	215990367	33260254	46	24082											
USH2A	7399	broad.mit.edu	37	chr1	216172316	216172316	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtactgttatagatgacactCcaaattgtaaaatcatgtgt	14	14	7	6	0	1	2	1	1	0	1	2	2	2	2	1	0	1	3	1	0	6	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:216172316C>A	uc001hku.1	-	34	6957	c.6570G>T	c.(6568-6570)TGG>TGT	p.W2190C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2190	Extracellular (Potential).|Fibronectin type-III 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGATGACACTCCAAATTGTAA	0.338										HNSCC(13;0.011)			17	55					9.16793e-09	1.13771e-08	1	0	A	216172316	A	A	216172316	3	1	136	1	0	0	0	0	1	0	0	0	17104	856	30	2	9194	2	USH2A	1	216172316	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	181949	216172316	33078305	47	24083											
MIA3	375056	broad.mit.edu	37	chr1	222803552	222803552	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaaaatgcttgatactcGtgtggctgaaaatagagatc	16	10	10	5	1	0	4	0	2	0	2	2	5	0	4	0	1	2	2	0	1	7	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:222803552G>C	uc001hnl.2	+	4	2999	c.2990G>C	c.(2989-2991)CGT>CCT	p.R997P	MIA3_uc009xea.1_Missense_Mutation_p.R833P	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	997	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		CTTGATACTCGTGTGGCTGAA	0.408													32	52					0	0	0	0	C	222803552	C	C	222803552	3	2	136	1	0	0	0	0	1	0	0	0	9618	1145	40	3	3004	3	MIA3	1	222803552	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	6631236	222803552	26447069	48	24084											
PRSS38	339501	broad.mit.edu	37	chr1	228033818	228033818	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taacatagaaatcacgcccaCtcctgctcagccagcccctg	11	7	6	17	1	2	1	2	0	0	1	3	1	3	1	5	0	4	1	5	0	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:228033818C>A	uc001hrh.2	+	5	890	c.890C>A	c.(889-891)ACT>AAT	p.T297N		NM_183062	NP_898885	A1L453	PRS38_HUMAN	marapsin 2 precursor	297					proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)|pancreas(1)	2						ATCACGCCCACTCCTGCTCAG	0.562													15	69					1.05317e-09	1.331e-09	1	0	A	228033818	A	A	228033818	3	1	136	1	0	0	0	0	1	0	0	0	12689	565	20	4	908	4	PRSS38	1	228033818	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5230266	228033818	21216803	49	24085											
ACTN2	88	broad.mit.edu	37	chr1	236914832	236914832	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggcggacggagagcggcaGtccatcatggccatccagaa	11	4	15	11	3	1	2	1	0	0	2	3	5	3	3	3	5	1	1	3	5	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:236914832G>T	uc001hyf.2	+	15	1923	c.1719G>T	c.(1717-1719)CAG>CAT	p.Q573H	ACTN2_uc001hyg.2_Missense_Mutation_p.Q365H|ACTN2_uc009xgi.1_Missense_Mutation_p.Q573H|ACTN2_uc010pxu.1_Missense_Mutation_p.Q262H|ACTN2_uc001hyh.2_Missense_Mutation_p.Q261H	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	573	Spectrin 3.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GAGAGCGGCAGTCCATCATGG	0.547													26	66					8.58068e-18	1.23036e-17	1	0	T	236914832	T	T	236914832	3	4	136	1	0	0	0	0	1	0	0	0	205	1020	36	4	1777	4	ACTN2	1	236914832	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	8881014	236914832	12335789	50	24086											
RYR2	6262	broad.mit.edu	37	chr1	237608741	237608741	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccacatggatgatggcataaGtttgtcgagatcccagcatg	11	10	11	9	1	0	2	0	1	0	1	2	4	1	3	2	2	1	3	2	2	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:237608741G>A	uc001hyl.1	+	14	1331	c.1211G>A	c.(1210-1212)AGT>AAT	p.S404N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	404	Cytoplasmic (By similarity).|MIR 5.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATGGCATAAGTTTGTCGAGA	0.413													28	69					0	0	0	0	A	237608741	A	A	237608741	3	1	136	1	0	0	0	0	1	0	0	0	13834	1029	36	4	1265	4	RYR2	1	237608741	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	693909	237608741	11641880	51	24087											
RYR2	6262	broad.mit.edu	37	chr1	237780711	237780711	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtttccgatacaacgaagtCatgcaagccttaaacatgtc	13	10	7	11	3	1	0	1	0	0	0	3	2	2	0	2	0	5	2	2	0	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:237780711C>A	uc001hyl.1	+	38	5961	c.5841C>A	c.(5839-5841)GTC>GTA	p.V1947V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1947	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACAACGAAGTCATGCAAGCCT	0.443													16	40					5.01169e-05	5.65187e-05	1	0	A	237780711	A	A	237780711	2	1	136	1	0	0	0	0	0	0	0	1	13834	813	29	2		2	RYR2	1	237780711	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	171970	237780711	11469910	52	24088											
RYR2	6262	broad.mit.edu	37	chr1	237791164	237791164	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgggctcaggagtctgtcaTtgaagaccccgagctggtga	9	9	14	9	1	3	3	2	2	1	1	3	5	3	4	2	3	1	2	2	3	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:237791164T>G	uc001hyl.1	+	41	6344	c.6224T>G	c.(6223-6225)ATT>AGT	p.I2075S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2075	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGTCTGTCATTGAAGACCCC	0.493													5	25					0	0	0	0	G	237791164	G	G	237791164	3	3	136	1	0	0	0	0	1	0	0	0	13834	1493	52	5	6386	5	RYR2	1	237791164	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	10453	237791164	11459457	53	24089											
RYR2	6262	broad.mit.edu	37	chr1	237951287	237951287	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgtttgtttgttttcataGgggagaagatggagaaaaag	12	15	13	1	0	1	3	1	0	0	3	1	5	1	3	0	3	0	3	0	3	4	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:237951287G>A	uc001hyl.1	+	92	13449	c.13329_splice	c.e92-1	p.E4443_splice		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTTTTCATAGGGGAGAAGAT	0.403													5	6					0	0	0	0	A	237951287	A	A	237951287	5	1	136	1	0	0	0	0	0	0	1	0	13834	1014	35	4	13694	4	RYR2	1	237951287	Splice_Site	SNP	G	TCGA-CR-7364-01A-11D-2012-08	160123	237951287	11299334	54	24090											
ZP4	57829	broad.mit.edu	37	chr1	238046042	238046042	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctccctcttggatacttacGgagcttttctggagggtcct	5	14	10	12	1	2	0	0	0	2	0	4	3	4	3	3	4	3	1	3	4	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:238046042G>T	uc001hym.2	-	11	1495	c.1495C>A	c.(1495-1497)CGT>AGT	p.R499S	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	499	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GGATACTTACGGAGCTTTTCT	0.403													10	40					1.76689e-08	2.17952e-08	1	0	T	238046042	T	T	238046042	3	4	136	1	0	0	0	0	1	0	0	0	18285	1130	39	3	135	3	ZP4	1	238046042	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	94755	238046042	11204579	55	24091											
FMN2	56776	broad.mit.edu	37	chr1	240370893	240370893	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctccgccgcctctaccCggagcaggcatactccctct	5	8	7	21	3	2	0	0	0	2	0	5	1	5	1	7	2	3	2	7	2	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:240370893C>T	uc010pyd.1	+	5	3006	c.2781C>T	c.(2779-2781)CCC>CCT	p.P927P	FMN2_uc010pye.1_Silent_p.P931P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	927	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CGCCTCTACCCGGAGCAGGCA	0.682													29	103					0	0	0	0	T	240370893	T	T	240370893	2	4	136	1	0	0	0	0	0	0	0	1	5982	639	23	1		1	FMN2	1	240370893	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2324851	240370893	8879728	56	24092											
FMN2	56776	broad.mit.edu	37	chr1	240371006	240371006	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcttcccggggcaggcatacCccttcctccccctcttcccg	3	10	7	21	2	2	0	0	0	2	0	6	0	6	0	7	3	1	2	7	3	1	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:240371006C>A	uc010pyd.1	+	5	3119	c.2894C>A	c.(2893-2895)CCC>CAC	p.P965H	FMN2_uc010pye.1_Missense_Mutation_p.P969H	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	965	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCAGGCATACCCCTTCCTCCC	0.701													21	28					0.000229342	0.000255375	1	0	A	240371006	A	A	240371006	3	1	136	1	0	0	0	0	1	0	0	0	5982	623	22	4	2912	4	FMN2	1	240371006	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	113	240371006	8879615	57	24093											
FH	2271	broad.mit.edu	37	chr1	241669303	241669303	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taattcacgtgatcactaacCtgtaagtgcagccacttttg	11	13	7	10	1	2	1	2	1	0	0	2	1	2	1	2	0	3	2	2	0	3	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:241669303C>A	uc001hyx.2	-	6	936	c.904G>T	c.(904-906)GGC>TGC	p.G302C		NM_000143	NP_000134	P07954	FUMH_HUMAN	fumarate hydratase precursor	302					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		GATCACTAACCTGTAAGTGCA	0.388			Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				15	31					2.31682e-05	2.62715e-05	1	0	A	241669303	A	A	241669303	3	1	136	1	0	0	0	0	1	0	0	0	5907	695	24	4	648	4	FH	1	241669303	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1298297	241669303	7581318	58	24094											
KIF26B	55083	broad.mit.edu	37	chr1	245865828	245865828	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cactggagtgtgtgacggagCgcctggagagccgtgtcaac	8	7	16	10	3	1	2	1	1	0	1	1	5	1	4	2	3	3	0	2	3	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:245865828C>A	uc001ibf.1	+	15	6687	c.6247C>A	c.(6247-6249)CGC>AGC	p.R2083S		NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	2083					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			TGTGACGGAGCGCCTGGAGAG	0.577													22	65					1.96895e-08	2.4191e-08	1	0	A	245865828	A	A	245865828	3	1	136	1	0	0	0	0	1	0	0	0	8334	768	27	3	6305	3	KIF26B	1	245865828	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	4196525	245865828	3384793	59	24095											
OR2L8	391190	broad.mit.edu	37	chr1	248112456	248112456	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcactgggtgtgggattcaGagtttcttcttcttggcatt	5	18	11	7	0	5	1	2	0	3	1	5	2	5	2	0	3	0	2	0	3	0	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr1:248112456G>T	uc001idt.1	+	1	297	c.297G>T	c.(295-297)CAG>CAT	p.Q99H	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GTGGGATTCAGAGTTTCTTCT	0.428													77	212					2.65773e-34	4.13722e-34	1	0	T	248112456	T	T	248112456	3	4	136	1	0	0	0	0	1	0	0	0	11063	933	33	2	299	2	OR2L8	1	248112456	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2246628	248112456	1138165	60	24096											
IAH1	285148	broad.mit.edu	37	chr2	9614667	9614668	+	5'Flank	INS	-	GCCCC	GCCCC																															ggcgcctctcgtggctggcgINSgccccgccccgccccgcccg																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:9614667_9614668insGCCCC	uc002qzr.2	+						IAH1_uc002qzs.2_5'Flank|IAH1_uc002qzt.2_5'Flank|IAH1_uc010yiz.1_5'Flank	NM_001039613	NP_001034702	Q2TAA2	IAH1_HUMAN	isoamyl acetate-hydrolyzing esterase 1 homolog						lipid catabolic process		hydrolase activity, acting on ester bonds				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CGTGGCTggcggccccgccccg	0.614													---	---	---								GCCCC	9614668	GCCCC	GCCCC	9614667	6	5	136	0	1	1	1	0	0	0	0	0	7510	1131	39	0		0	IAH1	2	9614667	5'Flank	INS	-	TCGA-CR-7364-01A-11D-2012-08		9614667	233584706	61	24097											
APOB	338	broad.mit.edu	37	chr2	21226197	21226197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatatggtgagttttttatCtggagaggactaaacagaga	14	12	12	3	0	1	3	0	1	1	2	1	7	1	4	0	3	1	1	0	3	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:21226197C>T	uc002red.2	-	29	12225	c.12097G>A	c.(12097-12099)GAT>AAT	p.D4033N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4033					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGTTTTTTATCTGGAGAGGAC	0.338													87	238					0	0	0	0	T	21226197	T	T	21226197	3	4	136	1	0	0	0	0	1	0	0	0	785	913	32	2	1598	2	APOB	2	21226197	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	11611530	21226197	221973176	62	24098											
OTOF	9381	broad.mit.edu	37	chr2	26696031	26696031	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctgggggccgagcggtcTgggggccggtagatgaagcg	6	5	21	9	4	1	2	0	1	1	1	1	3	1	2	2	6	3	2	2	6	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:26696031T>G	uc002rhk.2	-	29	3829	c.3702A>C	c.(3700-3702)CCA>CCC	p.P1234P	OTOF_uc010yla.1_5'UTR|OTOF_uc002rhh.2_Silent_p.P487P|OTOF_uc002rhi.2_Silent_p.P544P|OTOF_uc002rhj.2_Silent_p.P487P	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1234	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGAGCGGTCTGGGGGCCGGT	0.682													16	44					0	0	0	0	G	26696031	G	G	26696031	2	3	136	1	0	0	0	0	0	0	0	1	11357	1567	55	5		5	OTOF	2	26696031	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	5469834	26696031	216503342	63	24099											
ZNF513	130557	broad.mit.edu	37	chr2	27603383	27603383	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcgggtggctttgcttcCttcggggcatcgtgaccggc	2	11	16	12	4	0	1	0	1	0	0	3	1	1	1	2	5	2	4	2	5	0	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:27603383C>T	uc002rkk.2	-	1	211	c.11G>A	c.(10-12)AGG>AAG	p.R4K	ZNF513_uc002rkj.2_5'Flank	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	4					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTTTGCTTCCTTCGGGGCAT	0.711													4	9					0	0	0	0	T	27603383	T	T	27603383	3	4	136	1	0	0	0	0	1	0	0	0	18025	681	24	4	1630	4	ZNF513	2	27603383	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	907352	27603383	215595990	64	24100											
WDR43	23160	broad.mit.edu	37	chr2	29169565	29169565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaaagatgaagaaaatggcGaggacagagatacagcaagt	20	4	13	4	1	0	4	0	1	0	3	0	8	0	5	0	2	2	1	0	2	7	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:29169565G>A	uc002rmo.2	+	18	1986	c.1954G>A	c.(1954-1956)GAG>AAG	p.E652K		NM_015131	NP_055946	Q15061	WDR43_HUMAN	WD repeat domain 43	652						nucleolus				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					agaaaatggcgaggacagaga	0.149													3	8					0	0	0	0	A	29169565	A	A	29169565	3	1	136	1	0	0	0	0	1	0	0	0	17363	1059	37	1	2024	1	WDR43	2	29169565	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1566182	29169565	214029808	65	24101											
PSME4	23198	broad.mit.edu	37	chr2	54125132	54125132	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctatatgttcaaatttccAgggccttaaaaggaggaaaa	15	10	9	7	0	1	0	1	0	0	0	2	2	2	2	3	3	0	1	3	3	7	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:54125132A>T	uc002rxp.2	-	31	3537	c.3481T>A	c.(3481-3483)TGG>AGG	p.W1161R	PSME4_uc010yop.1_Missense_Mutation_p.W1047R|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Missense_Mutation_p.W536R|PSME4_uc010fbv.1_Missense_Mutation_p.W305R	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1161					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCAAATTTCCAGGGCCTTAAA	0.363													28	85					0	0	0	0	T	54125132	T	T	54125132	3	4	136	1	0	0	0	0	1	0	0	0	12771	188	7	5	2114	5	PSME4	2	54125132	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	24955567	54125132	189074241	66	24102											
XPO1	7514	broad.mit.edu	37	chr2	61760930	61760930	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggctccttctccatggtataAgcaattcaccacattatcta	11	13	5	12	0	3	0	1	0	2	0	5	0	4	0	3	2	1	3	3	2	5	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:61760930A>G	uc002sbj.2	-	2	831	c.103T>C	c.(103-105)TTA>CTA	p.L35L	XPO1_uc010fcl.2_Silent_p.L31L|XPO1_uc010ypn.1_Silent_p.L31L|XPO1_uc002sbk.2_5'UTR	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	35	Necessary for HTLV-1 Rex-mediated mRNA export.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			CCATGGTATAAGCAATTCACC	0.368													16	45					0	0	0	0	G	61760930	G	G	61760930	2	3	136	1	0	0	0	0	0	0	0	1	17513	69	3	5		5	XPO1	2	61760930	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	7635798	61760930	181438443	67	24103											
DYSF	8291	broad.mit.edu	37	chr2	71825794	71825794	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacgctcatcttctacgaGatcgagatctttggcgagcc	9	10	10	12	4	4	3	1	0	3	3	5	6	4	3	1	1	2	1	1	1	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:71825794G>T	uc002sie.2	+	33	3997	c.3621G>T	c.(3619-3621)GAG>GAT	p.E1207D	DYSF_uc010feg.2_Missense_Mutation_p.E1238D|DYSF_uc010feh.2_Missense_Mutation_p.E1193D|DYSF_uc002sig.3_Missense_Mutation_p.E1193D|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.E1207D|DYSF_uc010fef.2_Missense_Mutation_p.E1224D|DYSF_uc010fei.2_Missense_Mutation_p.E1224D|DYSF_uc010fek.2_Missense_Mutation_p.E1225D|DYSF_uc010fej.2_Missense_Mutation_p.E1194D|DYSF_uc010fel.2_Missense_Mutation_p.E1194D|DYSF_uc010feo.2_Missense_Mutation_p.E1239D|DYSF_uc010fem.2_Missense_Mutation_p.E1208D|DYSF_uc010fen.2_Missense_Mutation_p.E1225D|DYSF_uc002sif.2_Missense_Mutation_p.E1208D|DYSF_uc010yqy.1_Missense_Mutation_p.E88D	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1207	Cytoplasmic (Potential).|C2 4.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TCTTCTACGAGATCGAGATCT	0.567													29	55					5.45727e-16	7.59593e-16	1	0	T	71825794	T	T	71825794	3	4	136	1	0	0	0	0	1	0	0	0	4881	933	33	2	3943	2	DYSF	2	71825794	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	10064864	71825794	171373579	68	24104											
DCTN1	1639	broad.mit.edu	37	chr2	74594514	74594514	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctgcatagtacagtcctCaggctgttcggcaaggtgga	9	9	13	10	1	1	0	1	0	0	0	3	1	2	1	1	4	3	6	1	4	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:74594514C>G	uc002skx.2	-	19	2529	c.2218G>C	c.(2218-2220)GAG>CAG	p.E740Q	DCTN1_uc002skt.1_5'Flank|DCTN1_uc002skv.2_Missense_Mutation_p.E606Q|DCTN1_uc002sku.2_Missense_Mutation_p.E606Q|DCTN1_uc002skw.1_Missense_Mutation_p.E716Q|DCTN1_uc010ffd.2_Missense_Mutation_p.E720Q|DCTN1_uc002sky.2_Missense_Mutation_p.E703Q	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	740					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						GTACAGTCCTCAGGCTGTTCG	0.527													18	37					0	0	0	0	G	74594514	G	G	74594514	3	3	136	1	0	0	0	0	1	0	0	0	4323	835	29	2	1674	2	DCTN1	2	74594514	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2768720	74594514	168604859	69	24105											
FAM176A	84141	broad.mit.edu	37	chr2	75720464	75720464	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctccagccgctgggcgcgCtccagctcctccgcagaggt	4	7	12	18	4	0	1	0	0	0	1	5	1	5	1	6	2	2	4	6	2	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:75720464C>A	uc002sni.2	-	4	835	c.357G>T	c.(355-357)GAG>GAT	p.E119D	FAM176A_uc002snj.1_Missense_Mutation_p.E106D|FAM176A_uc002snk.1_Missense_Mutation_p.E119D	NM_001135032	NP_001128504	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	119					apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0						GCTGGGCGCGCTCCAGCTCCT	0.612													24	55					1.96895e-08	2.4191e-08	1	0	A	75720464	A	A	75720464	3	1	136	1	0	0	0	0	1	0	0	0	5527	796	28	4	105	4	FAM176A	2	75720464	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1125950	75720464	167478909	70	24106											
REG3A	5068	broad.mit.edu	37	chr2	79384406	79384406	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acattacagttataatctttCcacctcagaaatgctggaga	14	12	6	9	0	2	2	1	0	1	2	3	3	3	2	2	1	2	2	2	1	4	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:79384406C>A	uc002sod.1	-	5	729	c.474G>T	c.(472-474)TGG>TGT	p.W158C	REG3A_uc002soe.1_Missense_Mutation_p.W158C|REG3A_uc002sof.1_Missense_Mutation_p.W158C	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	158	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						TATAATCTTTCCACCTCAGAA	0.458													19	35					3.51602e-12	4.63305e-12	1	0	A	79384406	A	A	79384406	3	1	136	1	0	0	0	0	1	0	0	0	13277	856	30	2	57	2	REG3A	2	79384406	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3663942	79384406	163814967	71	24107											
CTNNA2	1496	broad.mit.edu	37	chr2	80136849	80136849	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcacgcgagacgaccggCgcgagaggatcgtggcggag	8	3	18	12	8	0	2	0	0	0	2	1	7	0	4	2	4	1	1	2	4	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:80136849C>A	uc010ysh.1	+	6	987	c.982C>A	c.(982-984)CGC>AGC	p.R328S	CTNNA2_uc010yse.1_Missense_Mutation_p.R328S|CTNNA2_uc010ysf.1_Missense_Mutation_p.R328S|CTNNA2_uc010ysg.1_Missense_Mutation_p.R328S	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	328					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AGACGACCGGCGCGAGAGGAT	0.637													27	94					4.22769e-11	5.50045e-11	1	0	A	80136849	A	A	80136849	3	1	136	1	0	0	0	0	1	0	0	0	4030	768	27	3		3	CTNNA2	2	80136849	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	752443	80136849	163062524	72	24108											
SH2D6	284948	broad.mit.edu	37	chr2	85662935	85662935	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gccctgggccgggagggcagGaaccgtgaggaggtgggagc	7	3	22	9	2	0	1	0	1	0	0	0	5	0	5	3	7	2	1	3	7	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:85662935G>C	uc002spq.2	+	3	560	c.399G>C	c.(397-399)AGG>AGC	p.R133S	SH2D6_uc002spo.2_RNA|SH2D6_uc002spp.2_RNA	NM_198482	NP_940884	Q7Z4S9	SH2D6_HUMAN	SH2 domain containing 6	133	SH2.									central_nervous_system(1)	1						GGGAGGGCAGGAACCGTGAGG	0.637													5	5					0	0	0	0	C	85662935	C	C	85662935	3	2	136	1	0	0	0	0	1	0	0	0	14303	1165	41	2	409	2	SH2D6	2	85662935	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	5526086	85662935	157536438	73	24109											
CNGA3	1261	broad.mit.edu	37	chr2	99013410	99013410	+	Frame_Shift_Del	DEL	G	-	-																															aggccctcaccgagtaccccGaagccaagaaggccctggag																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:99013410delG	uc002syt.2	+	8	2194	c.1777delG	c.(1777-1779)GAAfs	p.E593fs	CNGA3_uc002syu.2_Frame_Shift_Del_p.E575fs|CNGA3_uc010fij.2_Frame_Shift_Del_p.E597fs	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	593	cGMP.		E -> K (in ACHM2).		signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CGAGTACCCCGAAGCCAAGAA	0.612													---	---	---								-	99013410	-	-	99013410	7	5	136	1	0	1	0	1	0	0	0	0	3613	1059	37	0	1803	0	CNGA3	2	99013410	Frame_Shift_Del	DEL	G	TCGA-CR-7364-01A-11D-2012-08	13350475	99013410	144185963	74	24110											
MERTK	10461	broad.mit.edu	37	chr2	112751909	112751909	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatgctacgtgcacagtgAggattgcagccgtcaccaga	12	7	11	11	2	1	2	1	1	0	1	1	3	1	3	2	1	5	3	2	1	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:112751909A>G	uc002thk.1	+	9	1500	c.1378A>G	c.(1378-1380)AGG>GGG	p.R460G	MERTK_uc002thl.1_Missense_Mutation_p.R284G	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	460	Fibronectin type-III 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GTGCACAGTGAGGATTGCAGC	0.527													55	125					0	0	0	0	G	112751909	G	G	112751909	3	3	136	1	0	0	0	0	1	0	0	0	9532	295	11	5	1412	5	MERTK	2	112751909	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	13738499	112751909	130447464	75	24111											
IL1F9	56300	broad.mit.edu	37	chr2	113737705	113737706	+	Frame_Shift_Ins	INS	-	A	A																															ttgtgagaaggttggagaacINSagcccacattgcagctaaaa																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:113737705_113737706insA	uc002tio.1	+	4	349_350	c.280_281insA	c.(280-282)CAGfs	p.Q94fs	IL1F9_uc010fkr.1_Frame_Shift_Ins_p.Q59fs	NM_019618	NP_062564	Q9NZH8	IL36G_HUMAN	interleukin 1 family, member 9	94					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity				0						GGTTGGAGAACAGCCCACATTG	0.371													---	---	---								A	113737706	A	A	113737705	7	5	136	1	0	1	1	0	0	0	0	0	7696	479	17	0	290	0	IL1F9	2	113737705	Frame_Shift_Ins	INS	-	TCGA-CR-7364-01A-11D-2012-08	985796	113737705	129461668	76	24112											
CNTNAP5	129684	broad.mit.edu	37	chr2	125547524	125547524	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcctaggatgcattcgctCcttacacttgaatggacaga	10	12	8	11	1	0	2	0	1	0	1	3	4	2	4	2	2	2	2	2	2	3	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:125547524C>A	uc002tno.2	+	18	3159	c.2795C>A	c.(2794-2796)TCC>TAC	p.S932Y	CNTNAP5_uc010flu.2_Missense_Mutation_p.S933Y	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	932	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGCATTCGCTCCTTACACTTG	0.493													26	41					1.1804e-14	1.6139e-14	1	0	A	125547524	A	A	125547524	3	1	136	1	0	0	0	0	1	0	0	0	3665	855	30	2	2865	2	CNTNAP5	2	125547524	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	11809819	125547524	117651849	77	24113											
NCKAP5	344148	broad.mit.edu	37	chr2	133542404	133542404	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acacattcttctgaagaagtCctttttacaactctttgctg	10	16	5	10	0	3	2	0	1	3	1	4	2	4	2	1	0	3	1	1	0	4	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:133542404C>G	uc002ttp.2	-	14	2354	c.1980G>C	c.(1978-1980)AGG>AGC	p.R660S	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	660							protein binding				0						CTGAAGAAGTCCTTTTTACAA	0.443													31	89					0	0	0	0	G	133542404	G	G	133542404	3	3	136	1	0	0	0	0	1	0	0	0	10277	854	30	2	3777	2	NCKAP5	2	133542404	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	7994880	133542404	109656969	78	24114											
GALNT13	114805	broad.mit.edu	37	chr2	155157934	155157934	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcccagatttggcaatgtGgaggctccttggagattgtt	7	15	12	7	0	0	2	0	0	0	2	2	4	2	3	2	4	0	3	2	4	1	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:155157934G>T	uc002tyr.3	+	9	1555	c.988G>T	c.(988-990)GGA>TGA	p.G330*	GALNT13_uc002tyt.3_Nonsense_Mutation_p.G330*|GALNT13_uc010foc.1_Nonsense_Mutation_p.G149*|GALNT13_uc010fod.2_Nonsense_Mutation_p.G83*	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	330	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TTGGCAATGTGGAGGCTCCTT	0.403													51	131					1.39843e-22	2.08248e-22	1	0	T	155157934	T	T	155157934	4	4	136	1	0	0	0	0	0	1	0	0	6246	1349	47	4	1014	4	GALNT13	2	155157934	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	21615530	155157934	88041439	79	24115											
DHRS9	10170	broad.mit.edu	37	chr2	169938164	169938164	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaaaggaaaactaaagattGaagacatcactgataagtac	20	8	8	5	0	1	4	1	2	0	2	1	5	1	5	0	1	2	2	0	1	9	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:169938164G>A	uc002uep.2	+	5	1577	c.73G>A	c.(73-75)GAA>AAA	p.E25K	DHRS9_uc002ueq.2_Missense_Mutation_p.E25K|DHRS9_uc010zdc.1_Missense_Mutation_p.E85K|DHRS9_uc002uer.1_Missense_Mutation_p.E25K|DHRS9_uc010zdd.1_Missense_Mutation_p.E25K|DHRS9_uc010zde.1_Missense_Mutation_p.E25K	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	25					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						ACTAAAGATTGAAGACATCAC	0.418													24	59					0	0	0	0	A	169938164	A	A	169938164	3	1	136	1	0	0	0	0	1	0	0	0	4520	1291	45	2	75	2	DHRS9	2	169938164	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	14780230	169938164	73261209	80	24116											
TTN	7273	broad.mit.edu	37	chr2	179404975	179404975	+	Frame_Shift_Del	DEL	G	-	-																															ttcatgttgatctactttttGcatttcaatcaagtagcctg																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:179404975delG	uc010zfg.1	-	300	90438	c.90214delC	c.(90214-90216)CAAfs	p.Q30072fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Del_p.Q23767fs|TTN_uc010zfi.1_Frame_Shift_Del_p.Q23700fs|TTN_uc010zfj.1_Frame_Shift_Del_p.Q23575fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30999							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTACTTTTTGCATTTCAATC	0.443													---	---	---								-	179404975	-	-	179404975	7	5	136	1	0	1	0	1	0	0	0	0	16803	1328	46	0	10109	0	TTN	2	179404975	Frame_Shift_Del	DEL	G	TCGA-CR-7364-01A-11D-2012-08	9466811	179404975	63794398	81	24117											
TTN	7273	broad.mit.edu	37	chr2	179470318	179470318	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcaggtttgtcatgacgccGtttttcaatgatatatcctt	8	17	8	8	2	3	2	3	2	0	0	4	2	4	2	2	1	0	2	2	1	3	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:179470318G>T	uc010zfg.1	-	228	46224	c.46000C>A	c.(46000-46002)CGG>AGG	p.R15334R	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.R9029R|TTN_uc010zfi.1_Silent_p.R8962R|TTN_uc010zfj.1_Silent_p.R8837R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16261							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATGACGCCGTTTTTCAATG	0.433													26	97					4.59853e-10	5.89604e-10	1	0	T	179470318	T	T	179470318	2	4	136	1	0	0	0	0	0	0	0	1	16803	1144	40	3		3	TTN	2	179470318	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	65343	179470318	63729055	82	24118											
TTN	7273	broad.mit.edu	37	chr2	179556770	179556770	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggagcagcaggttccttctTaggcacaggaactggctttt	8	11	13	9	0	1	0	0	0	1	0	2	2	2	2	1	5	3	5	1	5	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:179556770T>C	uc010zfg.1	-	118	28227	c.28003A>G	c.(28003-28005)AAG>GAG	p.K9335E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K5996E|TTN_uc010fre.1_Missense_Mutation_p.K446E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10262							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTTCCTTCTTAGGCACAGGA	0.458													18	43					0	0	0	0	C	179556770	C	C	179556770	3	2	136	1	0	0	0	0	1	0	0	0	16803	1763	61	5	72762	5	TTN	2	179556770	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	86452	179556770	63642603	83	24119											
TTN	7273	broad.mit.edu	37	chr2	179597011	179597011	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttactttgcaggctagcTgggtggcatctcccttcttt	5	15	10	11	0	2	0	0	0	2	0	3	0	2	0	1	3	3	5	1	3	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:179597011T>A	uc010zfg.1	-	54	13177	c.12953A>T	c.(12952-12954)CAG>CTG	p.Q4318L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.Q979L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5245							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAGGCTAGCTGGGTGGCATC	0.403													55	112					0	0	0	0	A	179597011	A	A	179597011	3	1	136	1	0	0	0	0	1	0	0	0	16803	1580	55	5	88068	5	TTN	2	179597011	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	40241	179597011	63602362	84	24120											
TTN	7273	broad.mit.edu	37	chr2	179639041	179639041	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggttctgacgtccacgaCgagatgtaattgtatatttg	10	14	11	6	3	1	3	0	2	1	1	2	5	2	3	1	1	0	3	1	1	3	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:179639041C>A	uc010zfg.1	-	30	7174	c.6950G>T	c.(6949-6951)CGT>CTT	p.R2317L	TTN_uc010zfh.1_Missense_Mutation_p.R2271L|TTN_uc010zfi.1_Missense_Mutation_p.R2271L|TTN_uc010zfj.1_Missense_Mutation_p.R2271L|TTN_uc002unb.2_Missense_Mutation_p.R2317L|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2317							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACGTCCACGACGAGATGTAAT	0.408													34	88					3.62531e-18	5.22247e-18	1	0	A	179639041	A	A	179639041	3	1	136	1	0	0	0	0	1	0	0	0	16803	536	19	3	104370	3	TTN	2	179639041	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	42030	179639041	63560332	85	24121											
ITGA4	3676	broad.mit.edu	37	chr2	182392030	182392030	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttgtttttaccaggtttgtAaacccaacttcatttgtgta	9	19	6	7	0	1	0	1	0	0	0	1	0	1	0	2	1	3	4	2	1	5	9			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:182392030A>G	uc002unu.2	+	22	3109	c.2346A>G	c.(2344-2346)GTA>GTG	p.V782V	ITGA4_uc010frj.1_Silent_p.V264V|ITGA4_uc002unv.2_Silent_p.V27V	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	782	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CCAGGTTTGTAAACCCAACTT	0.299													3	34					0	0	0	0	G	182392030	G	G	182392030	2	3	136	1	0	0	0	0	0	0	0	1	7917	349	13	5		5	ITGA4	2	182392030	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	2752989	182392030	60807343	86	24122											
DNAH7	56171	broad.mit.edu	37	chr2	196749473	196749473	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagaatcttattaaatttcaAtcgatcatcatctgtacaag	16	14	4	7	1	5	1	3	0	2	1	6	2	5	1	0	0	1	1	0	0	8	4	rs149685696	by1000genomes	TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:196749473A>G	uc002utj.3	-	35	5700	c.5599T>C	c.(5599-5601)TTG>CTG	p.L1867L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1867					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTAAATTTCAATCGATCATCA	0.358													11	34					0	0	0	0	G	196749473	G	G	196749473	2	3	136	1	0	0	0	0	0	0	0	1	4628	98	4	5		5	DNAH7	2	196749473	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	14357443	196749473	46449900	87	24123											
PARD3B	117583	broad.mit.edu	37	chr2	205986412	205986412	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtatgaaaagtcagtcattGgctctcttaacatttttggt	11	16	8	6	0	3	1	2	1	1	0	4	1	3	1	0	2	1	2	0	2	4	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:205986412G>A	uc002var.1	+	8	1111	c.904G>A	c.(904-906)GGC>AGC	p.G302S	PARD3B_uc010fub.1_Missense_Mutation_p.G302S|PARD3B_uc002vao.1_Missense_Mutation_p.G302S|PARD3B_uc002vap.1_Missense_Mutation_p.G302S|PARD3B_uc002vaq.1_Missense_Mutation_p.G302S	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	302					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GTCAGTCATTGGCTCTCTTAA	0.463													34	38					0	0	0	0	A	205986412	A	A	205986412	3	1	136	1	0	0	0	0	1	0	0	0	11498	1348	47	4	934	4	PARD3B	2	205986412	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	9236939	205986412	37212961	88	24124											
MDH1B	130752	broad.mit.edu	37	chr2	207620081	207620081	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	actgcgcaggacgggagatgCcaggtcttgggtctccacca	8	7	14	12	2	2	1	0	0	2	1	3	3	2	2	3	4	2	1	3	4	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:207620081C>T	uc002vbs.2	-	5	617	c.562G>A	c.(562-564)GCA>ACA	p.A188T	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Missense_Mutation_p.A188T|MDH1B_uc010fuj.2_Missense_Mutation_p.A90T|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	188					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		ACGGGAGATGCCAGGTCTTGG	0.532													17	31					0	0	0	0	T	207620081	T	T	207620081	3	4	136	1	0	0	0	0	1	0	0	0	9462	739	26	4	1026	4	MDH1B	2	207620081	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1633669	207620081	35579292	89	24125											
CREB1	1385	broad.mit.edu	37	chr2	208420421	208420421	+	Frame_Shift_Del	DEL	A	-	-																															tgcagctgtaacagaagctgAaaaccaacaaatgacagttc																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:208420421delA	uc002vcc.2	+	2	313	c.62delA	c.(61-63)GAAfs	p.E21fs	CREB1_uc010ziz.1_Frame_Shift_Del_p.E19fs|CREB1_uc002vcd.2_Frame_Shift_Del_p.E21fs	NM_134442	NP_604391	P16220	CREB1_HUMAN	cAMP responsive element binding protein 1	21					activation of phospholipase C activity|axon guidance|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein dimerization activity|transcription cofactor activity		EWSR1/CREB1(42)	soft_tissue(42)|breast(1)|central_nervous_system(1)	44				LUSC - Lung squamous cell carcinoma(261;0.0768)|Epithelial(149;0.127)|Lung(261;0.145)	Adenosine monophosphate(DB00131)|Bromocriptine(DB01200)|Naloxone(DB01183)	ACAGAAGCTGAAAACCAACAA	0.433			T	EWSR1	clear cell sarcoma|angiomatoid fibrous histiocytoma								---	---	---								-	208420421	-	-	208420421	7	5	136	1	0	1	0	1	0	0	0	0	3869	246	9	0	64	0	CREB1	2	208420421	Frame_Shift_Del	DEL	A	TCGA-CR-7364-01A-11D-2012-08	800340	208420421	34778952	90	24126											
CRYGB	1419	broad.mit.edu	37	chr2	209010545	209010545	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtcgctgaggcccatccAttgctggtagtcagggtact	7	10	14	10	1	1	1	1	1	0	0	3	2	2	2	2	4	2	4	2	4	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:209010545A>G	uc002vcp.3	-	2	238	c.205T>C	c.(205-207)TGG>CGG	p.W69R		NM_005210	NP_005201	P07316	CRGB_HUMAN	crystallin, gamma B	69	Beta/gamma crystallin 'Greek key' 2.	Susceptible to oxidation.			visual perception		structural constituent of eye lens				0				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		AGGCCCATCCATTGCTGGTAG	0.572													21	44					0	0	0	0	G	209010545	G	G	209010545	3	3	136	1	0	0	0	0	1	0	0	0	3930	217	8	5	330	5	CRYGB	2	209010545	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	590124	209010545	34188828	91	24127											
PIKFYVE	200576	broad.mit.edu	37	chr2	209153476	209153476	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gattcatccagattcctcaaAtactcctctttcaacaagac	13	12	3	13	0	4	2	3	0	1	2	7	3	7	2	3	0	2	0	3	0	4	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:209153476A>G	uc002vcz.2	+	7	1003	c.845A>G	c.(844-846)AAT>AGT	p.N282S	PIKFYVE_uc010fun.1_5'UTR|PIKFYVE_uc002vcy.1_Missense_Mutation_p.N282S|PIKFYVE_uc002vcv.2_Missense_Mutation_p.N185S|PIKFYVE_uc002vcw.2_Missense_Mutation_p.N282S|PIKFYVE_uc002vcx.2_Missense_Mutation_p.N196S	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	282					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GATTCCTCAAATACTCCTCTT	0.358													19	29					0	0	0	0	G	209153476	G	G	209153476	3	3	136	1	0	0	0	0	1	0	0	0	11979	101	4	5	867	5	PIKFYVE	2	209153476	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	142931	209153476	34045897	92	24128											
SMARCAL1	50485	broad.mit.edu	37	chr2	217279485	217279485	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgaagagaatcgacaaaagGctctggcccgcagagctgag	13	6	13	9	2	1	4	0	2	1	2	2	6	1	4	1	2	1	3	1	2	4	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:217279485G>T	uc002vgc.3	+	3	388	c.58G>T	c.(58-60)GCT>TCT	p.A20S	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.A20S|SMARCAL1_uc010fvg.2_Missense_Mutation_p.A20S	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	20	Potential.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		TCGACAAAAGGCTCTGGCCCG	0.493									Schimke_Immuno-Osseous_Dysplasia				53	75					6.81593e-30	1.04522e-29	1	0	T	217279485	T	T	217279485	3	4	136	1	0	0	0	0	1	0	0	0	14837	1203	42	4	60	4	SMARCAL1	2	217279485	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	8126009	217279485	25919888	93	24129											
COL6A3	1293	broad.mit.edu	37	chr2	238303598	238303598	+	Frame_Shift_Del	DEL	C	-	-																															cttttccagtctgattggttCccccaatataagacatgttg																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr2:238303598delC	uc002vwl.2	-	3	626	c.341delG	c.(340-342)GGAfs	p.G114fs	COL6A3_uc002vwo.2_Intron|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Intron|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Frame_Shift_Del_p.G114fs	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	114	VWFA 1.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity	p.G114*(1)		ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTGATTGGTTCCCCCAATATA	0.458													---	---	---								-	238303598	-	-	238303598	7	5	136	1	0	1	0	1	0	0	0	0	3716	855	30	0	9407	0	COL6A3	2	238303598	Frame_Shift_Del	DEL	C	TCGA-CR-7364-01A-11D-2012-08	21024113	238303598	4895775	94	24130											
GRIP2	80852	broad.mit.edu	37	chr3	14555833	14555833	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaggctcgatgaagcacAcgaggggtggggaggacagg	10	5	19	7	2	1	1	1	1	0	0	2	5	1	3	0	7	1	2	0	7	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:14555833A>C	uc011avi.1	-	13	1754	c.1754T>G	c.(1753-1755)GTG>GGG	p.V585G	GRIP2_uc010heh.2_5'Flank|GRIP2_uc011avh.1_Missense_Mutation_p.V116G	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	487	PDZ 4.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						GATGAAGCACACGAGGGGTGG	0.602													3	3					0	0	0	0	C	14555833	C	C	14555833	3	2	136	1	0	0	0	0	1	0	0	0	6827	159	6	5	1722	5	GRIP2	3	14555833	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08		14555833	183466597	95	24131											
OXSM	54995	broad.mit.edu	37	chr3	25835674	25835674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttccacaccattgggagatGctgctgaaaacaaagctatc	13	9	8	11	0	0	2	0	1	0	1	2	3	1	2	2	1	4	3	2	1	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:25835674G>A	uc003cdn.2	+	3	1176	c.1069G>A	c.(1069-1071)GCT>ACT	p.A357T	OXSM_uc011awp.1_Missense_Mutation_p.A82T|OXSM_uc010hfh.2_Missense_Mutation_p.A274T	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	357					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						ATTGGGAGATGCTGCTGAAAA	0.453													18	21					0	0	0	0	A	25835674	A	A	25835674	3	1	136	1	0	0	0	0	1	0	0	0	11389	1319	46	4	1075	4	OXSM	3	25835674	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	11279841	25835674	172186756	96	24132											
DCLK3	85443	broad.mit.edu	37	chr3	36779796	36779796	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagatgcttctctccccttgCgtgcctctcttccagagtgg	5	13	9	14	1	2	2	0	0	2	2	6	2	4	2	4	1	3	1	4	1	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:36779796C>A	uc003cgi.2	-	2	846	c.355G>T	c.(355-357)GCA>TCA	p.A119S		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	119						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						TCTCCCCTTGCGTGCCTCTCT	0.567													54	109					6.3008e-33	9.71046e-33	1	0	A	36779796	A	A	36779796	3	1	136	1	0	0	0	0	1	0	0	0	4310	768	27	3	1607	3	DCLK3	3	36779796	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	10944122	36779796	161242634	97	24133											
XIRP1	165904	broad.mit.edu	37	chr3	39228156	39228156	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctatgcagctggccaacagCtgcacgctgctcctctcaga	8	9	9	15	1	2	1	1	0	2	1	4	1	3	1	2	1	6	6	2	1	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:39228156C>A	uc003cjk.1	-	2	3002	c.2781G>T	c.(2779-2781)CAG>CAT	p.Q927H	XIRP1_uc003cji.2_Missense_Mutation_p.Q927H|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	927							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGGCCAACAGCTGCACGCTGC	0.647													26	40					1.7881e-09	2.2506e-09	1	0	A	39228156	A	A	39228156	3	1	136	1	0	0	0	0	1	0	0	0	17497	796	28	4	2754	4	XIRP1	3	39228156	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2448360	39228156	158794274	98	24134											
ZNF621	285268	broad.mit.edu	37	chr3	40570897	40570897	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgcagagggccctgtacgggGaggtgatgctggagaattat	9	8	17	7	2	0	3	0	1	0	2	0	5	0	4	1	5	2	3	1	5	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:40570897G>C	uc003ckm.2	+	3	328	c.112G>C	c.(112-114)GAG>CAG	p.E38Q	ZNF621_uc003ckn.2_Missense_Mutation_p.E38Q|ZNF621_uc003cko.2_Intron|ZNF621_uc011aze.1_Intron	NM_001098414	NP_001091884	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	38	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		CCTGTACGGGGAGGTGATGCT	0.527													44	91					0	0	0	0	C	40570897	C	C	40570897	3	2	136	1	0	0	0	0	1	0	0	0	18112	1175	41	2	118	2	ZNF621	3	40570897	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1342741	40570897	157451533	99	24135											
ARIH2	10425	broad.mit.edu	37	chr3	49020700	49020700	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaagatttccatgacacCtaagttgggatgtggatgtg	11	12	12	6	0	0	3	0	2	0	1	1	5	1	5	2	2	0	1	2	2	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:49020700C>G	uc003cvb.2	+	16	1791	c.1479C>G	c.(1477-1479)ACC>ACG	p.T493T	ARIH2_uc003cvc.2_Silent_p.T493T|ARIH2_uc003cvf.2_Silent_p.T411T|ARIH2_uc010hkl.2_Silent_p.T411T	NM_006321	NP_006312	O95376	ARI2_HUMAN	ariadne homolog 2	493					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		TCCATGACACCTAAGTTGGGA	0.547													49	125					0	0	0	0	G	49020700	G	G	49020700	2	3	136	1	0	0	0	0	0	0	0	1	924	668	24	4		4	ARIH2	3	49020700	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	8449803	49020700	149001730	100	24136											
BSN	8927	broad.mit.edu	37	chr3	49691751	49691751	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgctcacctactgaaaccCagcccaccacccatggctac	10	7	5	19	0	2	1	1	1	1	0	2	1	2	1	5	1	5	2	5	1	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:49691751C>G	uc003cxe.3	+	5	4876	c.4762C>G	c.(4762-4764)CAG>GAG	p.Q1588E		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1588					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TACTGAAACCCAGCCCACCAC	0.627													18	33					0	0	0	0	G	49691751	G	G	49691751	3	3	136	1	0	0	0	0	1	0	0	0	1535	595	21	4	4780	4	BSN	3	49691751	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	671051	49691751	148330679	101	24137											
SEMA3B	7869	broad.mit.edu	37	chr3	50314079	50314079	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaaagggccgtaaccggaGgacccacgcccctgagcctc	10	3	13	15	3	0	2	0	1	0	1	1	5	0	4	6	3	2	1	6	3	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:50314079G>A	uc003cyu.2	+	19	2434	c.2192G>A	c.(2191-2193)AGG>AAG	p.R731K	SEMA3B_uc003cyt.2_Missense_Mutation_p.R730K|SEMA3B_uc003cyv.2_Missense_Mutation_p.R618K|SEMA3B_uc003cyw.2_Missense_Mutation_p.R454K|SEMA3B_uc010hli.2_Missense_Mutation_p.R623K|SEMA3B_uc003cyx.2_Missense_Mutation_p.R617K|SEMA3B_uc003cyy.2_Missense_Mutation_p.R388K|SEMA3B_uc011bdo.1_Missense_Mutation_p.R388K|C3orf45_uc003cyz.2_5'Flank	NM_004636	NP_004627	Q13214	SEM3B_HUMAN	semaphorin 3B isoform 1 precursor	731	Arg-rich (basic).				axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			lung(2)|central_nervous_system(2)|kidney(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CGTAACCGGAGGACCCACGCC	0.721													3	9					0	0	0	0	A	50314079	A	A	50314079	3	1	136	1	0	0	0	0	1	0	0	0	14090	1000	35	4	2257	4	SEMA3B	3	50314079	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	622328	50314079	147708351	102	24138											
DNAH1	25981	broad.mit.edu	37	chr3	52428568	52428568	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgtcagaccgggcttggCgagacatcctagcactctcg	7	8	13	13	3	2	2	1	0	1	2	4	3	3	2	2	3	1	3	2	3	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:52428568C>A	uc011bef.1	+	67	10975	c.10714C>A	c.(10714-10716)CGA>AGA	p.R3572R	DNAH1_uc003ddv.2_Silent_p.R430R	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3637					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCGGGCTTGGCGAGACATCCT	0.572													11	31					3.07112e-06	3.56088e-06	1	0	A	52428568	A	A	52428568	2	1	136	1	0	0	0	0	0	0	0	1	4619	760	27	3		3	DNAH1	3	52428568	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2114489	52428568	145593862	103	24139											
ITIH4	3700	broad.mit.edu	37	chr3	52857966	52857966	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcagaagaggctgtacCggccacttacagcttcccgc	9	6	11	15	2	0	2	0	0	0	2	1	2	1	2	4	3	3	4	4	3	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:52857966C>T	uc003dfz.2	-	10	1262	c.1226G>A	c.(1225-1227)CGG>CAG	p.R409Q	ITIH4_uc011bel.1_Missense_Mutation_p.R139Q|ITIH4_uc003dfy.2_Missense_Mutation_p.R273Q|ITIH4_uc011bem.1_Missense_Mutation_p.R409Q|ITIH4_uc011ben.1_Missense_Mutation_p.R409Q	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	409	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GAGGCTGTACCGGCCACTTAC	0.582													17	23					0	0	0	0	T	52857966	T	T	52857966	3	4	136	1	0	0	0	0	1	0	0	0	7945	652	23	1	1626	1	ITIH4	3	52857966	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	429398	52857966	145164464	104	24140											
CNTN3	5067	broad.mit.edu	37	chr3	74347306	74347306	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggaaagcaacaacataccCaaaaccttcaccattctgta	16	7	5	13	1	2	0	1	0	1	0	2	1	2	1	3	1	5	2	3	1	7	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:74347306C>G	uc003dpm.1	-	17	2283	c.2203G>C	c.(2203-2205)GGG>CGG	p.G735R		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	735	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACAACATACCCAAAACCTTCA	0.458													8	24					0	0	0	0	G	74347306	G	G	74347306	3	3	136	1	0	0	0	0	1	0	0	0	3657	594	21	4	907	4	CNTN3	3	74347306	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	21489340	74347306	123675124	105	24141											
VGLL3	389136	broad.mit.edu	37	chr3	87018113	87018113	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgatgcaggttgtgtccCggccaaggactgggatcagc	7	9	15	10	1	2	1	1	1	1	0	3	3	3	3	2	4	2	2	2	4	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:87018113C>A	uc003dqn.2	-	3	928	c.564G>T	c.(562-564)CCG>CCT	p.P188P		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GGTTGTGTCCCGGCCAAGGAC	0.597													37	50					8.73648e-17	1.2355e-16	1	0	A	87018113	A	A	87018113	2	1	136	1	0	0	0	0	0	0	0	1	17228	639	23	3		3	VGLL3	3	87018113	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	12670807	87018113	111004317	106	24142											
OR5K4	403278	broad.mit.edu	37	chr3	98072954	98072954	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagatgttagagaatttctTttctgaggatagaattattt	13	17	8	3	0	2	4	0	1	2	3	2	6	2	5	0	1	0	1	0	1	6	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:98072954T>A	uc011bgv.1	+	1	257	c.257T>A	c.(256-258)TTT>TAT	p.F86Y		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GAGAATTTCTTTTCTGAGGAT	0.438													115	268					0	0	0	0	A	98072954	A	A	98072954	3	1	136	1	0	0	0	0	1	0	0	0	11223	1841	64	5	259	5	OR5K4	3	98072954	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	11054841	98072954	99949476	107	24143											
KIAA1524	57650	broad.mit.edu	37	chr3	108270064	108270064	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtggatcattgctatcaTgtgggagtgtttgttcaatt	8	17	11	5	0	3	0	3	0	0	0	3	2	3	2	0	2	1	3	0	2	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:108270064T>C	uc003dxb.3	-	21	2919	c.2650A>G	c.(2650-2652)ATG>GTG	p.M884V		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	884						cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						ATTGCTATCATGTGGGAGTGT	0.378													10	45					0	0	0	0	C	108270064	C	C	108270064	3	2	136	1	0	0	0	0	1	0	0	0	8278	1464	51	5	71	5	KIAA1524	3	108270064	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	10197110	108270064	89752366	108	24144											
SEC61A1	29927	broad.mit.edu	37	chr3	127783841	127783841	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccaacctcatgaatctcatCgccaccatctttgtctttgc	8	13	4	16	1	4	1	2	1	3	0	6	1	4	1	4	0	2	0	4	0	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:127783841C>T	uc003ekb.2	+	8	922	c.738C>T	c.(736-738)ATC>ATT	p.I246I	RUVBL1_uc003eke.2_3'UTR|RUVBL1_uc003ekf.2_3'UTR|SEC61A1_uc003ekc.2_Silent_p.I193I|SEC61A1_uc003ekd.2_Silent_p.I126I|SEC61A1_uc003ekg.2_Intron	NM_013336	NP_037468	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit	246	Helical; (Potential).				protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			ovary(1)	1						TGAATCTCATCGCCACCATCT	0.512													31	115					0	0	0	0	T	127783841	T	T	127783841	2	4	136	1	0	0	0	0	0	0	0	1	14065	874	31	1		1	SEC61A1	3	127783841	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	19513777	127783841	70238589	109	24145											
PLXND1	23129	broad.mit.edu	37	chr3	129304823	129304823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctggcgcacatcgatctcgGaaggcaggacggtcatggca	9	6	14	12	4	2	0	1	0	1	0	4	3	2	2	1	6	0	3	1	6	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:129304823G>A	uc003emx.2	-	5	1923	c.1823C>T	c.(1822-1824)TCC>TTC	p.S608F		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	608	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane		p.S608S(1)		large_intestine(1)	1						ATCGATCTCGGAAGGCAGGAC	0.657													10	213					0	0	0	0	A	129304823	A	A	129304823	3	1	136	1	0	0	0	0	1	0	0	0	12182	1174	41	2	4082	2	PLXND1	3	129304823	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1520982	129304823	68717607	110	24146											
TMCC1	23023	broad.mit.edu	37	chr3	129389575	129389575	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgagtgaggcaatctctCtgggctttgagactacagcg	10	10	13	8	1	2	3	0	3	2	1	3	5	2	3	0	2	2	2	0	2	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:129389575C>A	uc003emz.3	-	5	1610	c.1109G>T	c.(1108-1110)AGA>ATA	p.R370I	TMCC1_uc003emy.3_Missense_Mutation_p.R46I|TMCC1_uc011blc.1_Missense_Mutation_p.R191I|TMCC1_uc010htg.2_Missense_Mutation_p.R256I	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	370						integral to membrane				skin(1)	1						GGCAATCTCTCTGGGCTTTGA	0.527													17	51					4.7546e-09	5.93605e-09	1	0	A	129389575	A	A	129389575	3	1	136	1	0	0	0	0	1	0	0	0	16058	913	32	2	864	2	TMCC1	3	129389575	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	84752	129389575	68632855	111	24147											
AMOTL2	51421	broad.mit.edu	37	chr3	134070860	134070860	+	RNA	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttttcatccgaatccactggGgaatgggacgattttgcttt	8	15	10	8	2	1	0	1	0	0	0	3	4	3	2	2	3	1	1	2	3	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:134070860G>A	uc010htx.1	-	2		c.283C>T						Q9Y2J4	AMOL2_HUMAN	Homo sapiens mRNA for ribosomal protein L39 variant protein.											large_intestine(1)	1						AATCCACTGGGGAATGGGACG	0.428													20	53					0	0	0	0	A	134070860	A	A	134070860	1	1	136	0	1	0	0	0	0	0	0	0	584	1247	43	4		4	AMOTL2	3	134070860	RNA	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4681285	134070860	63951570	112	24148											
EPHB1	2047	broad.mit.edu	37	chr3	134911580	134911580	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaccatcctaacatcattcGcctggagggtgtggtcacca	9	9	10	13	2	2	0	2	0	0	0	4	2	3	1	4	3	1	0	4	3	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:134911580G>T	uc003eqt.2	+	11	2265	c.2045G>T	c.(2044-2046)CGC>CTC	p.R682L	EPHB1_uc003equ.2_Missense_Mutation_p.R243L	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	682	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						AACATCATTCGCCTGGAGGGT	0.537													21	38					7.92052e-27	1.19973e-26	1	0	T	134911580	T	T	134911580	3	4	136	1	0	0	0	0	1	0	0	0	5198	1087	38	3	2087	3	EPHB1	3	134911580	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	840720	134911580	63110850	113	24149											
DBR1	51163	broad.mit.edu	37	chr3	137881194	137881194	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcatattcaccacacacaTgatgttcttccttggacttc	9	15	4	13	0	3	1	2	1	1	0	5	2	4	2	2	1	0	1	2	1	1	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:137881194T>A	uc003erv.2	-	8	1308	c.1172A>T	c.(1171-1173)CAT>CTT	p.H391L	DBR1_uc003eru.2_Missense_Mutation_p.H340L|DBR1_uc003ert.2_Missense_Mutation_p.H159L	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	391						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						ACCACACACATGATGTTCTTC	0.408													15	36					0	0	0	0	A	137881194	A	A	137881194	3	1	136	1	0	0	0	0	1	0	0	0	4274	1464	51	5	466	5	DBR1	3	137881194	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	2969614	137881194	60141236	114	24150											
TRPC1	7220	broad.mit.edu	37	chr3	142523472	142523472	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacggcaaaacagtttaaaGgtaagaaattagaagcttga	20	8	9	4	1	0	3	0	1	0	2	0	3	0	3	0	2	3	4	0	2	9	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:142523472G>C	uc003evc.2	+	12	2290	c.2154G>C	c.(2152-2154)AAG>AAC	p.K718N	TRPC1_uc003evb.2_Missense_Mutation_p.K684N	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	718					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						ACAGTTTAAAGGTAAGAAATT	0.303													12	35					0	0	0	0	C	142523472	C	C	142523472	3	2	136	1	0	0	0	0	1	0	0	0	16645	1014	35	4	2094	4	TRPC1	3	142523472	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4642278	142523472	55498958	115	24151											
ZIC1	7545	broad.mit.edu	37	chr3	147131245	147131245	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccctccacagacaacccGaccacaagctccttatcgcc	10	7	4	20	2	1	1	0	0	1	1	5	2	3	1	6	0	2	1	6	0	3	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:147131245G>T	uc003ewe.2	+	3	1970	c.1251G>T	c.(1249-1251)CCG>CCT	p.P417P		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	417	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CAGACAACCCGACCACAAGCT	0.592													17	98					2.5808e-16	3.62485e-16	1	0	T	147131245	T	T	147131245	2	4	136	1	0	0	0	0	0	0	0	1	17745	1045	37	3		3	ZIC1	3	147131245	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4607773	147131245	50891185	116	24152											
CLRN1	7401	broad.mit.edu	37	chr3	150659511	150659511	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagagaatgacattgacgtgGatgctcactgggattgcttt	11	12	12	6	1	1	3	1	2	0	1	1	6	1	5	0	2	2	2	0	2	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:150659511G>T	uc003eyk.1	-	2	582	c.291C>A	c.(289-291)ATC>ATA	p.I97I	CLRN1OS_uc011bny.1_Intron|CLRN1_uc003eyj.2_Silent_p.I21I|CLRN1_uc010hvj.1_RNA	NM_174878	NP_777367	P58418	CLRN1_HUMAN	clarin 1 isoform a	97					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CATTGACGTGGATGCTCACTG	0.393													10	22					0.000673444	0.000741869	1	0	T	150659511	T	T	150659511	2	4	136	1	0	0	0	0	0	0	0	1	3572	1164	41	2		2	CLRN1	3	150659511	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	3528266	150659511	47362919	117	24153											
SI	6476	broad.mit.edu	37	chr3	164725726	164725726	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ataaggtggataatttagttCgtcatttctgcattgattag	11	17	9	4	1	2	1	1	1	1	0	3	2	2	2	0	2	1	2	0	2	4	8	rs145734588	byFrequency	TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:164725726C>G	uc003fei.2	-	36	4302	c.4240G>C	c.(4240-4242)GAA>CAA	p.E1414Q		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1414	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAATTTAGTTCGTCATTTCTG	0.244										HNSCC(35;0.089)			23	48					0	0	0	0	G	164725726	G	G	164725726	3	3	136	1	0	0	0	0	1	0	0	0	14362	893	31	3	1295	3	SI	3	164725726	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	14066215	164725726	33296704	118	24154											
BCHE	590	broad.mit.edu	37	chr3	165548790	165548790	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaaaccaaaagagaaatCtgatgcatatgattgtgact	19	9	8	5	0	1	5	0	3	1	2	1	6	1	5	1	0	2	1	1	0	6	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:165548790C>A	uc003fem.3	-	2	192	c.32G>T	c.(31-33)AGA>ATA	p.R11I	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	11					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAAGAGAAATCTGATGCATAT	0.333													10	22					0.000673444	0.000741869	1	0	A	165548790	A	A	165548790	3	1	136	1	0	0	0	0	1	0	0	0	1360	913	32	2	1788	2	BCHE	3	165548790	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	823064	165548790	32473640	119	24155											
SKIL	6498	broad.mit.edu	37	chr3	170078601	170078601	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcttgttttcaagttggagGagaaaagagactctgtttgc	10	15	11	5	0	3	2	1	0	2	2	3	5	3	3	0	2	1	3	0	2	3	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:170078601G>T	uc003fgu.2	+	2	1194	c.482G>T	c.(481-483)GGA>GTA	p.G161V	SKIL_uc011bps.1_Missense_Mutation_p.G141V|SKIL_uc003fgv.2_Missense_Mutation_p.G161V|SKIL_uc003fgw.2_Missense_Mutation_p.G161V	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	161					cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			CAAGTTGGAGGAGAAAAGAGA	0.418													32	98					5.60225e-13	7.55937e-13	1	0	T	170078601	T	T	170078601	3	4	136	1	0	0	0	0	1	0	0	0	14423	1174	41	2	484	2	SKIL	3	170078601	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4529811	170078601	27943829	120	24156											
TNIK	23043	broad.mit.edu	37	chr3	170945955	170945955	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaaaataaagacacttaccCctgtgacatccataaccttg	15	9	5	12	0	0	2	0	1	0	1	1	2	1	2	4	0	2	1	4	0	6	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr3:170945955C>A	uc003fhh.2	-	3	524	c.179G>T	c.(178-180)GGG>GTG	p.G60V	TNIK_uc003fhi.2_Missense_Mutation_p.G60V|TNIK_uc003fhj.2_Missense_Mutation_p.G60V|TNIK_uc003fhk.2_Missense_Mutation_p.G60V|TNIK_uc003fhl.2_Missense_Mutation_p.G60V|TNIK_uc003fhm.2_Missense_Mutation_p.G60V|TNIK_uc003fhn.2_Missense_Mutation_p.G60V|TNIK_uc003fho.2_Missense_Mutation_p.G60V	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	60	Protein kinase.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GACACTTACCCCTGTGACATC	0.274													15	51					4.7546e-09	5.93605e-09	1	0	A	170945955	A	A	170945955	3	1	136	1	0	0	0	0	1	0	0	0	16379	637	22	4	4027	4	TNIK	3	170945955	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	867354	170945955	27076475	121	24157											
FGFRL1	53834	broad.mit.edu	37	chr4	1018993	1018993	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctccggcagccccccagcActtactgggcccaggcccag	6	5	11	19	1	1	0	0	0	1	0	2	0	1	0	6	3	3	2	6	3	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:1018993A>T	uc003gce.2	+	7	1534	c.1373A>T	c.(1372-1374)CAC>CTC	p.H458L	FGFRL1_uc003gcf.2_Missense_Mutation_p.H458L|FGFRL1_uc003gcg.2_Missense_Mutation_p.H458L|FGFRL1_uc010ibo.2_Missense_Mutation_p.H458L	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	458	Cytoplasmic (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GCCCCCCAGCACTTACTGGGC	0.498													6	19					0	0	0	0	T	1018993	T	T	1018993	3	4	136	1	0	0	0	0	1	0	0	0	5901	159	6	5	1395	5	FGFRL1	4	1018993	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08		1018993	190135283	122	24158											
LETM1	3954	broad.mit.edu	37	chr4	1827372	1827372	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgacacgctgcctgcagctcCttgacattcaggctgtccac	7	9	9	16	2	1	1	1	1	0	0	3	2	3	1	3	1	3	4	3	1	0	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:1827372C>A	uc003gdv.2	-	7	1416	c.1119G>T	c.(1117-1119)AAG>AAT	p.K373N		NM_012318	NP_036450	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane	373	Mitochondrial matrix (Potential).|LETM1.				cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			central_nervous_system(1)	1			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			CCTGCAGCTCCTTGACATTCA	0.577													12	37					3.07112e-06	3.56088e-06	1	0	A	1827372	A	A	1827372	3	1	136	1	0	0	0	0	1	0	0	0	8774	680	24	4	1132	4	LETM1	4	1827372	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	808379	1827372	189326904	123	24159											
JAKMIP1	152789	broad.mit.edu	37	chr4	6107640	6107640	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtaggccgtgtgccgtcgctGctcctgctcgcgctccagct	2	10	13	16	5	0	0	0	0	0	0	4	0	2	0	4	1	4	6	4	1	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:6107640G>T	uc003giu.3	-	3	460	c.184C>A	c.(184-186)CAG>AAG	p.Q62K	JAKMIP1_uc010idb.1_Missense_Mutation_p.Q62K|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Missense_Mutation_p.Q62K|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Missense_Mutation_p.Q62K|JAKMIP1_uc010ide.2_Missense_Mutation_p.Q62K	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	62	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TGCCGTCGCTGCTCCTGCTCG	0.602													20	35					5.26018e-13	7.11333e-13	1	0	T	6107640	T	T	6107640	3	4	136	1	0	0	0	0	1	0	0	0	7979	1328	46	4	2462	4	JAKMIP1	4	6107640	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4280268	6107640	185046636	124	24160											
SLIT2	9353	broad.mit.edu	37	chr4	20493400	20493400	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaggtcaccagtcatttatGgctccttcttgtagtgtttt	6	19	8	8	0	3	0	2	0	1	0	4	0	4	0	2	2	0	3	2	2	3	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:20493400G>C	uc003gpr.1	+	9	996	c.792G>C	c.(790-792)ATG>ATC	p.M264I	SLIT2_uc003gps.1_Missense_Mutation_p.M264I	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	264	LRRNT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AGTCATTTATGGCTCCTTCTT	0.403													29	108					0	0	0	0	C	20493400	C	C	20493400	3	2	136	1	0	0	0	0	1	0	0	0	14804	1348	47	4	826	4	SLIT2	4	20493400	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	14385760	20493400	170660876	125	24161											
TBC1D1	23216	broad.mit.edu	37	chr4	38047458	38047458	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtaataaagccagaggcctGcaggaacactccatcagtgt	13	7	11	10	0	1	1	1	0	0	1	2	2	2	2	3	3	3	2	3	3	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:38047458G>A	uc003gtb.2	+	10	1906	c.1563G>A	c.(1561-1563)CTG>CTA	p.L521L	TBC1D1_uc011byd.1_Silent_p.L521L|TBC1D1_uc010ifd.2_Silent_p.L268L|TBC1D1_uc011byf.1_Silent_p.L392L	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	521						nucleus	Rab GTPase activator activity			ovary(1)	1						CCAGAGGCCTGCAGGAACACT	0.443													26	87					0	0	0	0	A	38047458	A	A	38047458	2	1	136	1	0	0	0	0	0	0	0	1	15663	1306	46	4		4	TBC1D1	4	38047458	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	17554058	38047458	153106818	126	24162											
KLB	152831	broad.mit.edu	37	chr4	39436011	39436011	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtttgccaaccctatccatgGggatggcgactatccagagg	9	9	12	11	1	0	1	0	0	0	1	2	3	2	2	4	4	2	1	4	4	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:39436011G>T	uc003gua.2	+	2	1104	c.1007G>T	c.(1006-1008)GGG>GTG	p.G336V	KLB_uc011byj.1_Missense_Mutation_p.G336V	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	336	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						CCTATCCATGGGGATGGCGAC	0.468													23	69					1.50039e-11	1.96449e-11	1	0	T	39436011	T	T	39436011	3	4	136	1	0	0	0	0	1	0	0	0	8371	1232	43	4	1013	4	KLB	4	39436011	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1388553	39436011	151718265	127	24163											
COX7B2	170712	broad.mit.edu	37	chr4	46737052	46737052	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagtggctgtaaacacccatGtagcaacacagaaagcagtt	15	7	10	9	0	0	1	0	0	0	1	0	2	0	1	1	1	4	6	1	1	5	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:46737052G>A	uc003gxf.2	-	3	338	c.158C>T	c.(157-159)ACA>ATA	p.T53I	COX7B2_uc010ige.2_RNA	NM_130902	NP_570972	Q8TF08	CX7B2_HUMAN	cytochrome c oxidase subunit VIIb2 precursor	53	Helical; (By similarity).					integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity				0						AAACACCCATGTAGCAACACA	0.433													22	61					0	0	0	0	A	46737052	A	A	46737052	3	1	136	1	0	0	0	0	1	0	0	0	3798	1377	48	4	91	4	COX7B2	4	46737052	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	7301041	46737052	144417224	128	24164											
GABRA4	2557	broad.mit.edu	37	chr4	46981101	46981101	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatatatgtcagttttcaCttctgtaacaggacctaacg	12	13	7	9	1	3	0	2	0	1	0	3	2	3	1	1	1	2	2	1	1	4	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:46981101C>A	uc003gxg.2	-	3	359	c.220G>T	c.(220-222)GTG>TTG	p.V74L		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	74	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCAGTTTTCACTTCTGTAACA	0.343													14	32					1.49906e-05	1.70926e-05	1	0	A	46981101	A	A	46981101	3	1	136	1	0	0	0	0	1	0	0	0	6197	565	20	4	1472	4	GABRA4	4	46981101	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	244049	46981101	144173175	129	24165											
NFXL1	152518	broad.mit.edu	37	chr4	47853907	47853907	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcatttccttgcacgttGtgtcacattctattgaaacc	8	16	6	11	1	3	1	2	1	1	0	4	1	4	1	2	0	2	3	2	0	2	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:47853907G>T	uc010igh.2	-	21	2651	c.2474C>A	c.(2473-2475)ACA>AAA	p.T825K	NFXL1_uc003gxo.2_Missense_Mutation_p.T150K|NFXL1_uc003gxp.2_Missense_Mutation_p.T825K|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Missense_Mutation_p.T825K	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	825	Potential.					integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						CTTGCACGTTGTGTCACATTC	0.353													18	72					1.15919e-05	1.32662e-05	1	0	T	47853907	T	T	47853907	3	4	136	1	0	0	0	0	1	0	0	0	10442	1377	48	4	273	4	NFXL1	4	47853907	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	872806	47853907	143300369	130	24166											
CNGA1	1259	broad.mit.edu	37	chr4	47939007	47939007	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttgcaaatataatctccagGactgtagacttggggttgca	11	12	10	8	0	1	1	0	0	1	1	2	2	1	2	1	3	2	4	1	3	4	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:47939007G>T	uc003gxt.3	-	11	1770	c.1504C>A	c.(1504-1506)CCT>ACT	p.P502T	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Missense_Mutation_p.P571T	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	502	cGMP (Potential).|Cytoplasmic (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						TAATCTCCAGGACTGTAGACT	0.438													19	106					5.03518e-11	6.53728e-11	1	0	T	47939007	T	T	47939007	3	4	136	1	0	0	0	0	1	0	0	0	3611	1174	41	2	572	2	CNGA1	4	47939007	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	85100	47939007	143215269	131	24167											
SGCB	6443	broad.mit.edu	37	chr4	52895089	52895089	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcccttgctgaaaaacaatcTtcaaaaaaaacagtttattg	17	12	4	8	0	2	1	1	1	1	0	3	1	3	1	1	0	3	2	1	0	8	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:52895089T>A	uc003gzj.2	-	4	490	c.430_splice	c.e4-1	p.I144_splice	SGCB_uc011bzp.1_Splice_Site_p.I74_splice	NM_000232	NP_000223	Q16585	SGCB_HUMAN	sarcoglycan, beta						cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma					0			GBM - Glioblastoma multiforme(4;7.63e-12)|LUSC - Lung squamous cell carcinoma(32;0.00204)			AAAAACAATCTTCAAAAAAAA	0.294													8	32					0	0	0	0	A	52895089	A	A	52895089	5	1	136	1	0	0	0	0	0	0	1	0	14265	1623	56	5	540	5	SGCB	4	52895089	Splice_Site	SNP	T	TCGA-CR-7364-01A-11D-2012-08	4956082	52895089	138259187	132	24168											
USP46	64854	broad.mit.edu	37	chr4	53494256	53494256	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgctgggccttgtatgcCaacacattctcccggaatgg	7	13	10	11	1	1	0	0	0	1	0	2	1	1	1	3	3	3	2	3	3	3	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:53494256C>A	uc003gzn.2	-	3	377	c.192G>T	c.(190-192)TTG>TTT	p.L64F	USP46_uc003gzm.3_Missense_Mutation_p.L57F|USP46_uc011bzr.1_Missense_Mutation_p.L41F|USP46_uc011bzs.1_5'UTR	NM_022832	NP_073743	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46 isoform 1	64					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0295)			CCTTGTATGCCAACACATTCT	0.517													14	31					6.72482e-11	8.67629e-11	1	0	A	53494256	A	A	53494256	3	1	136	1	0	0	0	0	1	0	0	0	17145	593	21	4	936	4	USP46	4	53494256	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	599167	53494256	137660020	133	24169											
SCFD2	152579	broad.mit.edu	37	chr4	54179841	54179841	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaggttttctctgcttgccGcttccactagatgtctccga	5	14	9	13	2	2	1	0	0	2	1	5	2	3	1	3	1	2	4	3	1	1	5	rs138747864		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:54179841G>T	uc003gzu.2	-	3	1231	c.1097C>A	c.(1096-1098)GCG>GAG	p.A366E	SCFD2_uc010igm.2_Missense_Mutation_p.A366E	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	366					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TCTGCTTGCCGCTTCCACTAG	0.468													15	31					7.93312e-07	9.33842e-07	1	0	T	54179841	T	T	54179841	3	4	136	1	0	0	0	0	1	0	0	0	13955	1087	38	3	985	3	SCFD2	4	54179841	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	685585	54179841	136974435	134	24170											
UGT2B11	10720	broad.mit.edu	37	chr4	70080467	70080467	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatgcgatcattcttttcCagtcactgtttctttctcat	7	18	5	11	1	5	0	3	0	3	0	7	1	6	0	1	0	1	2	1	0	1	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:70080467C>T	uc003heh.2	-						uc003hei.1_RNA	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,						estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						CATTCTTTTCCAGTCACTGTT	0.358													46	113					0	0	0	0	T	70080467	T	T	70080467	1	4	136	0	1	0	0	0	0	0	0	0	17025	609	21	4		4	UGT2B11	4	70080467	5'Flank	SNP	C	TCGA-CR-7364-01A-11D-2012-08	15900626	70080467	121073809	135	24171											
UGT2A1	10941	broad.mit.edu	37	chr4	70513300	70513300	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	attggccaaatcaaaacattCccaccaagagtggttcctat	14	10	6	11	0	1	1	1	0	0	1	3	1	3	1	4	2	1	1	4	2	5	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:70513300C>T	uc003hem.3	-	1	126	c.63G>A	c.(61-63)GGG>GGA	p.G21G	UGT2A1_uc011caq.1_Silent_p.G21G|UGT2A1_uc010ihu.2_Silent_p.G21G|UGT2A1_uc010iht.2_Silent_p.G21G	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	21	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						TCAAAACATTCCCACCAAGAG	0.388													11	25					0	0	0	0	T	70513300	T	T	70513300	2	4	136	1	0	0	0	0	0	0	0	1	17021	842	30	2		2	UGT2A1	4	70513300	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	432833	70513300	120640976	136	24172											
PPBP	5473	broad.mit.edu	37	chr4	74853045	74853045	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tacaattttcttgattctggGagcatctgggtccaggcaga	9	13	11	8	0	3	2	0	1	3	1	4	3	4	3	1	3	2	2	1	3	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:74853045G>A	uc003hhj.2	-	3	411	c.331C>T	c.(331-333)CCC>TCC	p.P111S		NM_002704	NP_002695	P02775	CXCL7_HUMAN	pro-platelet basic protein precursor	111					chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			TTGATTCTGGGAGCATCTGGG	0.428													22	65					0	0	0	0	A	74853045	A	A	74853045	3	1	136	1	0	0	0	0	1	0	0	0	12358	1174	41	2	59	2	PPBP	4	74853045	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4339745	74853045	116301231	137	24173											
CNOT6L	246175	broad.mit.edu	37	chr4	78650155	78650155	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtctggatgagcttcacatCagaatactctgggtcccaat	10	11	10	10	0	4	2	2	1	2	1	5	3	5	3	1	3	2	1	1	3	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:78650155C>T	uc011ccd.1	-	10	1236	c.1105G>A	c.(1105-1107)GAT>AAT	p.D369N	CNOT6L_uc003hks.2_Missense_Mutation_p.D369N|CNOT6L_uc003hkt.1_Missense_Mutation_p.D212N	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	369					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						AGCTTCACATCAGAATACTCT	0.428													40	95					0	0	0	0	T	78650155	T	T	78650155	3	4	136	1	0	0	0	0	1	0	0	0	3638	826	29	2	574	2	CNOT6L	4	78650155	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3797110	78650155	112504121	138	24174											
ARHGAP24	83478	broad.mit.edu	37	chr4	86915782	86915782	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgatgattagcaaacaTgattgcctctttcccaaaga	13	12	7	9	0	2	4	1	3	1	1	3	4	3	4	2	0	3	1	2	0	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:86915782T>C	uc003hpk.2	+	9	1424	c.975T>C	c.(973-975)CAT>CAC	p.H325H	ARHGAP24_uc003hpl.2_Silent_p.H230H|ARHGAP24_uc010ikf.2_Silent_p.H240H|ARHGAP24_uc003hpm.2_Silent_p.H232H	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	325	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		TTAGCAAACATGATTGCCTCT	0.418													46	125					0	0	0	0	C	86915782	C	C	86915782	2	2	136	1	0	0	0	0	0	0	0	1	873	1461	51	5		5	ARHGAP24	4	86915782	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	8265627	86915782	104238494	139	24175											
EGF	1950	broad.mit.edu	37	chr4	110902034	110902034	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgaacatatttgcaaaaaGaggcttggaactgcttggtg	12	12	12	5	0	0	2	0	1	0	1	0	3	0	3	0	3	4	3	0	3	5	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:110902034G>A	uc003hzy.3	+	15	2726	c.2274G>A	c.(2272-2274)AAG>AAA	p.K758K	EGF_uc011cfu.1_Silent_p.K716K|EGF_uc011cfv.1_Silent_p.K758K|EGF_uc010imk.2_5'UTR	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	758	Extracellular (Potential).|EGF-like 5.				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TTTGCAAAAAGAGGCTTGGAA	0.438													22	90					0	0	0	0	A	110902034	A	A	110902034	2	1	136	1	0	0	0	0	0	0	0	1	4984	933	33	2		2	EGF	4	110902034	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	23986252	110902034	80252242	140	24176											
MAML3	55534	broad.mit.edu	37	chr4	140640738	140640738	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggcatgcctgggactccctgGctcaggccagacatgaccat	8	7	12	14	0	1	2	1	1	0	1	2	3	2	3	4	4	1	2	4	4	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:140640738G>A	uc003ihz.1	-	7	3893	c.3141C>T	c.(3139-3141)AGC>AGT	p.S1047S	MGST2_uc010ioi.1_Intron|MAML3_uc011chd.1_Silent_p.S515S	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	1048					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					GGACTCCCTGGCTCAGGCCAG	0.647													5	31					0	0	0	0	A	140640738	A	A	140640738	2	1	136	1	0	0	0	0	0	0	0	1	9260	1194	42	4		4	MAML3	4	140640738	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	29738704	140640738	50513538	141	24177											
RNF150	57484	broad.mit.edu	37	chr4	141868813	141868813	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcctagtgactcaccggcaGggcaggatccggacaacgtc	10	5	13	13	3	1	1	1	1	0	0	3	3	2	3	3	4	2	2	3	4	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:141868813G>T	uc003iio.1	-	4	1539	c.885C>A	c.(883-885)CCC>CCA	p.P295P	RNF150_uc010iok.1_Silent_p.P253P|RNF150_uc003iip.1_Silent_p.P295P	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	295	Cytoplasmic (Potential).|RING-type; atypical.					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					CTCACCGGCAGGGCAGGATCC	0.562													18	69					3.8784e-16	5.4105e-16	1	0	T	141868813	T	T	141868813	2	4	136	1	0	0	0	0	0	0	0	1	13516	987	35	4		4	RNF150	4	141868813	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1228075	141868813	49285463	142	24178											
INPP4B	8821	broad.mit.edu	37	chr4	143130163	143130163	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagaaagctcaccaagttCttttatctcctggtttctgt	8	16	8	9	0	4	1	1	0	3	1	5	2	4	1	2	2	1	3	2	2	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:143130163C>A	uc003iix.3	-	14	1448	c.853G>T	c.(853-855)GAA>TAA	p.E285*	INPP4B_uc003iiw.3_Nonsense_Mutation_p.E285*|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Nonsense_Mutation_p.E100*|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Nonsense_Mutation_p.E156*	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	285					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					TCACCAAGTTCTTTTATCTCC	0.363													10	42					2.27111e-07	2.72533e-07	1	0	A	143130163	A	A	143130163	4	1	136	1	0	0	0	0	0	1	0	0	7792	922	32	2	1977	2	INPP4B	4	143130163	Nonsense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1261350	143130163	48024113	143	24179											
KIAA0922	23240	broad.mit.edu	37	chr4	154556600	154556600	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagaaaacatgaactatgcCaatggcttcccctgtcctgc	11	10	8	12	0	0	2	0	1	0	1	2	2	2	2	4	1	4	2	4	1	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:154556600C>T	uc003inm.3	+	34	4483	c.4431C>T	c.(4429-4431)GCC>GCT	p.A1477A	KIAA0922_uc010ipp.2_Silent_p.A1478A|KIAA0922_uc010ipq.2_Silent_p.A1246A	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1477	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				TGAACTATGCCAATGGCTTCC	0.438													21	67					0	0	0	0	T	154556600	T	T	154556600	2	4	136	1	0	0	0	0	0	0	0	1	8240	581	21	4		4	KIAA0922	4	154556600	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	11426437	154556600	36597676	144	24180											
DCHS2	54798	broad.mit.edu	37	chr4	155256021	155256021	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataagaaataagtacttactCaagggctctcttgctttcac	13	13	6	9	0	3	1	2	0	1	1	4	1	3	1	0	1	3	3	0	1	6	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:155256021C>G	uc003inw.2	-	8	1215	c.1215G>C	c.(1213-1215)TTG>TTC	p.L405F	DCHS2_uc003inx.2_Missense_Mutation_p.L904F	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	405	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AGTACTTACTCAAGGGCTCTC	0.373													23	63					0	0	0	0	G	155256021	G	G	155256021	3	3	136	1	0	0	0	0	1	0	0	0	4305	840	29	2	7703	2	DCHS2	4	155256021	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	699421	155256021	35898255	145	24181											
NAF1	92345	broad.mit.edu	37	chr4	164087774	164087774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggctgtgtccctggcacagGggcagagcccggagacggag	7	4	18	12	3	0	2	0	0	0	2	1	4	1	3	2	6	1	3	2	6	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:164087774G>A	uc003iqj.2	-	1	300	c.106C>T	c.(106-108)CCT>TCT	p.P36S	NAF1_uc010iqw.1_Missense_Mutation_p.P36S|NAF1_uc003iqk.2_RNA	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	36					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				CCTGGCACAGGGGCAGAGCCC	0.667													8	18					0	0	0	0	A	164087774	A	A	164087774	3	1	136	1	0	0	0	0	1	0	0	0	10193	1232	43	4	1551	4	NAF1	4	164087774	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	8831753	164087774	27066502	146	24182											
ADAM29	11086	broad.mit.edu	37	chr4	175896769	175896769	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccaatatcacagccctccGgatgtggtgattcctgtgag	8	10	10	13	1	1	2	1	2	0	0	3	3	3	3	5	2	1	0	5	2	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:175896769G>T	uc003iuc.2	+	5	763	c.93G>T	c.(91-93)CCG>CCT	p.P31P	ADAM29_uc003iud.2_Silent_p.P31P|ADAM29_uc010irr.2_Silent_p.P31P|ADAM29_uc011cki.1_Silent_p.P31P	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	31			P -> L (in a colorectal cancer sample; somatic mutation).		proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding	p.P31L(1)		skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ACAGCCCTCCGGATGTGGTGA	0.517													25	54					4.4004e-07	5.26006e-07	1	0	T	175896769	T	T	175896769	2	4	136	1	0	0	0	0	0	0	0	1	247	1103	39	3		3	ADAM29	4	175896769	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	11808995	175896769	15257507	147	24183											
WDR17	116966	broad.mit.edu	37	chr4	177056354	177056354	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcactataaaagtctgggaTataaacacattaacagcagt	17	9	8	7	0	1	0	0	0	1	0	1	1	1	1	0	2	3	2	0	2	7	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:177056354T>C	uc003iuj.2	+	9	1422	c.1266T>C	c.(1264-1266)GAT>GAC	p.D422D	WDR17_uc003iuk.2_Silent_p.D398D|WDR17_uc003ium.3_Silent_p.D398D|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	422	WD 6.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		AAGTCTGGGATATAAACACAT	0.383													19	37					0	0	0	0	C	177056354	C	C	177056354	2	2	136	1	0	0	0	0	0	0	0	1	17345	1403	49	5		5	WDR17	4	177056354	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	1159585	177056354	14097922	148	24184											
WDR17	116966	broad.mit.edu	37	chr4	177084375	177084375	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggcacagtactaggagAgtctgcagcaccagcaaccc	11	6	12	12	0	1	1	0	0	1	1	1	2	1	1	2	2	5	5	2	2	3	2	rs141454308	by1000genomes	TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr4:177084375A>T	uc003iuj.2	+	23	3149	c.2993A>T	c.(2992-2994)GAG>GTG	p.E998V	WDR17_uc003iuk.2_Missense_Mutation_p.E974V|WDR17_uc003ium.3_Missense_Mutation_p.E974V|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.E217V	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	998										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GTACTAGGAGAGTCTGCAGCA	0.408													24	49					0	0	0	0	T	177084375	T	T	177084375	3	4	136	1	0	0	0	0	1	0	0	0	17345	304	11	5	3079	5	WDR17	4	177084375	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	28021	177084375	14069901	149	24185											
SLC12A7	10723	broad.mit.edu	37	chr5	1076277	1076277	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtagaacttgaagcgtggaCgccagttgggggtacgtagc	9	8	17	7	3	0	2	0	1	0	1	0	3	0	3	1	4	4	4	1	4	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:1076277C>A	uc003jbu.2	-	14	1889	c.1823G>T	c.(1822-1824)CGT>CTT	p.R608L		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	608	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GAAGCGTGGACGCCAGTTGGG	0.642													8	14					0.000673444	0.000741869	1	0	A	1076277	A	A	1076277	3	1	136	1	0	0	0	0	1	0	0	0	14453	536	19	3	1472	3	SLC12A7	5	1076277	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08		1076277	179838983	150	24186											
ADAMTS16	170690	broad.mit.edu	37	chr5	5146522	5146522	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctatcaaggctctttgcGatcacacagaaactcctcag	11	12	6	12	1	5	1	3	0	2	1	6	2	6	1	1	1	2	1	1	1	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:5146522G>T	uc003jdl.2	+	3	593	c.455G>T	c.(454-456)CGA>CTA	p.R152L	ADAMTS16_uc003jdk.1_Missense_Mutation_p.R152L|ADAMTS16_uc003jdj.1_Missense_Mutation_p.R152L	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	152					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						GGCTCTTTGCGATCACACAGA	0.537													38	102					1.58521e-26	2.38941e-26	1	0	T	5146522	T	T	5146522	3	4	136	1	0	0	0	0	1	0	0	0	261	1058	37	3	465	3	ADAMTS16	5	5146522	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4070245	5146522	175768738	151	24187											
ADAMTS16	170690	broad.mit.edu	37	chr5	5306737	5306737	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacatttgccgaagcccagcCtggagctggaacgtgcctgc	8	7	12	14	2	0	0	0	0	0	0	0	3	0	2	4	2	7	1	4	2	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:5306737C>A	uc003jdl.2	+	21	3445	c.3307C>A	c.(3307-3309)CTG>ATG	p.L1103M		NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1103	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						GAAGCCCAGCCTGGAGCTGGA	0.562													15	47					1.52009e-12	2.0246e-12	1	0	A	5306737	A	A	5306737	3	1	136	1	0	0	0	0	1	0	0	0	261	680	24	4	3389	4	ADAMTS16	5	5306737	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	160215	5306737	175608523	152	24188											
ADCY2	108	broad.mit.edu	37	chr5	7521006	7521006	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcaaggagcacctggtCtggcaggtgggtgcacctcc	7	6	17	11	0	1	0	0	0	1	0	2	2	2	2	3	7	2	4	3	7	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:7521006C>A	uc003jdz.1	+	3	631	c.564C>A	c.(562-564)GTC>GTA	p.V188V		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	188	Helical; (Potential).			VWQILANVIIFICGNLAGAY -> GLADPGQCDHFHLWEPG XTN (in Ref. 1; AAP97285).	activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AGCACCTGGTCTGGCAGGTGG	0.607													18	64					8.34094e-07	9.79981e-07	1	0	A	7521006	A	A	7521006	2	1	136	1	0	0	0	0	0	0	0	1	294	900	32	2		2	ADCY2	5	7521006	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2214269	7521006	173394254	153	24189											
SEMA5A	9037	broad.mit.edu	37	chr5	9119147	9119147	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccacgcacacccggccccCgtgcctgggagtggggttgc	4	6	14	17	3	0	0	0	0	0	0	1	1	1	1	5	4	2	2	5	4	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:9119147C>A	uc003jek.2	-	15	2600	c.1888G>T	c.(1888-1890)GGG>TGG	p.G630W		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	630	TSP type-1 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						ACCCGGCCCCCGTGCCTGGGA	0.677													20	39					3.51602e-12	4.63305e-12	1	0	A	9119147	A	A	9119147	3	1	136	1	0	0	0	0	1	0	0	0	14102	652	23	3	1372	3	SEMA5A	5	9119147	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1598141	9119147	171796113	154	24190											
SEMA5A	9037	broad.mit.edu	37	chr5	9337825	9337825	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaatacaatatctctcacCttgctcctacaacaagttct	14	12	2	13	0	3	0	1	0	2	0	5	0	4	0	2	0	4	2	2	0	8	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:9337825C>A	uc003jek.2	-	4	936	c.224G>T	c.(223-225)AGA>ATA	p.R75I		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	75	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TATCTCTCACCTTGCTCCTAC	0.423													8	35					0.000274275	0.00030486	1	0	A	9337825	A	A	9337825	3	1	136	1	0	0	0	0	1	0	0	0	14102	695	24	4	3080	4	SEMA5A	5	9337825	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	218678	9337825	171577435	155	24191											
DNAH5	1767	broad.mit.edu	37	chr5	13758967	13758967	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagttacctgcttttcagtCatggcctgttcatactcagc	7	14	8	12	0	4	0	4	0	0	0	4	0	4	0	2	1	4	4	2	1	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:13758967C>A	uc003jfd.2	-	61	10449	c.10407G>T	c.(10405-10407)ATG>ATT	p.M3469I	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3469	Stalk (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCTTTTCAGTCATGGCCTGTT	0.532									Kartagener_syndrome				57	133					4.88482e-21	7.1706e-21	1	0	A	13758967	A	A	13758967	3	1	136	1	0	0	0	0	1	0	0	0	4626	826	29	2	3543	2	DNAH5	5	13758967	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	4421142	13758967	167156293	156	24192											
DNAH5	1767	broad.mit.edu	37	chr5	13786380	13786380	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagctgcaggaacatattcaGacgctcttttaggtgactaa	12	11	10	8	1	2	2	1	1	1	1	2	4	2	3	0	2	3	3	0	2	4	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:13786380G>A	uc003jfd.2	-	52	8770	c.8728C>T	c.(8728-8730)CTG>TTG	p.L2910L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2910					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AACATATTCAGACGCTCTTTT	0.428									Kartagener_syndrome				14	48					0	0	0	0	A	13786380	A	A	13786380	2	1	136	1	0	0	0	0	0	0	0	1	4626	933	33	2		2	DNAH5	5	13786380	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	27413	13786380	167128880	157	24193											
CAPSL	133690	broad.mit.edu	37	chr5	35910057	35910057	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttccccattctggtactttgGgtggtgttttgcattatata	6	19	9	7	0	1	0	0	0	1	0	2	0	2	0	2	3	2	3	2	3	4	9			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:35910057G>A	uc003jjt.1	-	4	531	c.436C>T	c.(436-438)CCA>TCA	p.P146S	CAPSL_uc003jju.1_Missense_Mutation_p.P146S	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	146	EF-hand 3.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			TGGTACTTTGGGTGGTGTTTT	0.368													28	87					0	0	0	0	A	35910057	A	A	35910057	3	1	136	1	0	0	0	0	1	0	0	0	2651	1232	43	4	198	4	CAPSL	5	35910057	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	22123677	35910057	145005203	158	24194											
UGT3A1	133688	broad.mit.edu	37	chr5	35965526	35965526	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtttttccatcaagcctcCaatataaacagtgttgggaa	13	12	8	8	0	1	0	1	0	0	0	3	1	3	1	3	2	2	2	3	2	6	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:35965526C>T	uc003jjv.1	-	4	962	c.805G>A	c.(805-807)GGA>AGA	p.G269R	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.G269R|UGT3A1_uc011cor.1_Missense_Mutation_p.G235R|UGT3A1_uc003jjy.1_Missense_Mutation_p.G215R	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	269	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATCAAGCCTCCAATATAAACA	0.428													16	62					0	0	0	0	T	35965526	T	T	35965526	3	4	136	1	0	0	0	0	1	0	0	0	17031	603	21	4	864	4	UGT3A1	5	35965526	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	55469	35965526	144949734	159	24195											
DAB2	1601	broad.mit.edu	37	chr5	39381644	39381644	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggctgtaggttgtcctgtGggtgacgcctggcctgaagg	5	10	18	8	1	0	2	0	2	0	0	1	2	1	2	3	5	0	3	3	5	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:39381644G>T	uc003jlx.2	-	11	1947	c.1416C>A	c.(1414-1416)CCC>CCA	p.P472P	DAB2_uc003jlw.2_Silent_p.P451P	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	472					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			GTTGTCCTGTGGGTGACGCCT	0.582													32	77					9.65021e-13	1.28808e-12	1	0	T	39381644	T	T	39381644	2	4	136	1	0	0	0	0	0	0	0	1	4235	1335	47	4		4	DAB2	5	39381644	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	3416118	39381644	141533616	160	24196											
HCN1	348980	broad.mit.edu	37	chr5	45303729	45303729	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taagagccatctgtcagcttCatttctttactggattttgt	8	18	7	8	0	4	1	2	0	2	1	4	2	4	2	1	1	3	1	1	1	2	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:45303729C>G	uc003jok.2	-	6	1615	c.1590G>C	c.(1588-1590)ATG>ATC	p.M530I		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	530	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CTGTCAGCTTCATTTCTTTAC	0.353													16	66					0	0	0	0	G	45303729	G	G	45303729	3	3	136	1	0	0	0	0	1	0	0	0	7035	826	29	2	1094	2	HCN1	5	45303729	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5922085	45303729	135611531	161	24197											
HSPB3	8988	broad.mit.edu	37	chr5	53751686	53751686	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accaggaagagtttgaagctCgaggtctagaagactgcagg	13	7	14	7	1	1	4	0	1	1	3	2	6	1	5	1	3	2	3	1	3	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:53751686C>T	uc003jph.1	+	1	242	c.67C>T	c.(67-69)CGA>TGA	p.R23*		NM_006308	NP_006299	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3	23					cell death|response to heat|response to unfolded protein	cytoplasm|nucleus					0		Lung NSC(810;0.00104)				GTTTGAAGCTCGAGGTCTAGA	0.502													31	49					0	0	0	0	T	53751686	T	T	53751686	4	4	136	1	0	0	0	0	0	1	0	0	7460	876	31	1	69	1	HSPB3	5	53751686	Nonsense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	8447957	53751686	127163574	162	24198											
FBN2	2201	broad.mit.edu	37	chr5	127782271	127782271	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagtttcctccttggcatatCcctgggatagcctggcattc	6	13	9	13	0	0	0	0	0	0	0	4	1	3	1	4	3	1	3	4	3	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:127782271C>A	uc003kuu.2	-	7	1294	c.855G>T	c.(853-855)GGG>GGT	p.G285G	FBN2_uc003kuv.2_Silent_p.G252G|FBN2_uc003kuw.3_Silent_p.G285G|FBN2_uc003kux.1_Silent_p.G285G	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	285	EGF-like 4; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTTGGCATATCCCTGGGATAG	0.393													20	25					6.44725e-10	8.23224e-10	1	0	A	127782271	A	A	127782271	2	1	136	1	0	0	0	0	0	0	0	1	5735	842	30	2		2	FBN2	5	127782271	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	74030585	127782271	53132989	163	24199											
CSF2	1437	broad.mit.edu	37	chr5	131409633	131409633	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgaatgccatccaggaggcCcggcgtctcctgaacctgag	8	7	13	13	2	1	3	0	3	1	0	3	4	2	4	5	3	2	0	5	3	2	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:131409633C>A	uc003kwf.2	+	1	149	c.117C>A	c.(115-117)GCC>GCA	p.A39A		NM_000758	NP_000749	P04141	CSF2_HUMAN	colony stimulating factor 2 precursor	39					immune response|negative regulation of cytolysis|positive regulation of DNA replication|positive regulation of interleukin-23 production|positive regulation of macrophage derived foam cell differentiation|positive regulation of podosome assembly|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|growth factor activity				0		all_cancers(142;4.28e-07)|all_lung(232;2.81e-05)|Lung NSC(810;0.000693)|Lung SC(612;0.122)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Sargramostim(DB00020)	TCCAGGAGGCCCGGCGTCTCC	0.647													21	45					4.96729e-08	6.0548e-08	1	0	A	131409633	A	A	131409633	2	1	136	1	0	0	0	0	0	0	0	1	3950	610	22	4		4	CSF2	5	131409633	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3627362	131409633	49505627	164	24200											
CATSPER3	347732	broad.mit.edu	37	chr5	134345142	134345142	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaagcaggtgattctgcagCggcagcaggaggagatcagc	12	5	16	8	1	2	3	1	1	1	2	2	5	2	4	0	4	5	4	0	4	1	1	rs142712287		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:134345142C>A	uc003lag.2	+	6	966	c.898C>A	c.(898-900)CGG>AGG	p.R300R		NM_178019	NP_821138	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	300					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GATTCTGCAGCGGCAGCAGGA	0.562													31	60					2.14196e-07	2.57535e-07	1	0	A	134345142	A	A	134345142	2	1	136	1	0	0	0	0	0	0	0	1	2701	759	27	3		3	CATSPER3	5	134345142	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2935509	134345142	46570118	165	24201											
PCDHA6	56142	broad.mit.edu	37	chr5	140209910	140209910	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggtgtgctccagcgcagTggggagctggtcgtactcgc	4	9	17	11	3	0	0	0	0	0	0	3	1	1	1	1	4	4	5	1	4	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:140209910T>A	uc003lho.2	+	1	2261	c.2234T>A	c.(2233-2235)GTG>GAG	p.V745E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.V745E	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	745	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAGCGCAGTGGGGAGCTGG	0.677													17	32					0	0	0	0	A	140209910	A	A	140209910	3	1	136	1	0	0	0	0	1	0	0	0	11582	1696	59	5	2236	5	PCDHA6	5	140209910	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	5864768	140209910	40705350	166	24202											
SLC6A7	6534	broad.mit.edu	37	chr5	149576820	149576820	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acctcacctgcaccgtcagcCccagcgaggagtactggagg	9	5	12	15	2	2	0	2	0	0	0	2	3	2	2	5	3	4	2	5	3	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:149576820C>A	uc003lrr.2	+	4	936	c.565C>A	c.(565-567)CCC>ACC	p.P189T		NM_014228	NP_055043	Q99884	SC6A7_HUMAN	solute carrier family 6, member 7	189	Extracellular (Potential).					integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity				0		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	CACCGTCAGCCCCAGCGAGGA	0.652													13	27					0.00136819	0.00149654	1	0	A	149576820	A	A	149576820	3	1	136	1	0	0	0	0	1	0	0	0	14753	623	22	4	579	4	SLC6A7	5	149576820	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	9366910	149576820	31338440	167	24203											
SLC36A2	153201	broad.mit.edu	37	chr5	150696552	150696552	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtagaacgtggtgacctcCaggagcggtgggatgatgag	10	7	18	6	2	0	4	0	3	0	1	1	7	1	6	2	4	2	1	2	4	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:150696552C>T	uc003lty.2	-	10	1408	c.1278G>A	c.(1276-1278)CTG>CTA	p.L426L	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Silent_p.L228L	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	426	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGTGACCTCCAGGAGCGGTG	0.647													9	17					0	0	0	0	T	150696552	T	T	150696552	2	4	136	1	0	0	0	0	0	0	0	1	14658	581	21	4		4	SLC36A2	5	150696552	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1119732	150696552	30218708	168	24204											
NSD1	64324	broad.mit.edu	37	chr5	176709508	176709508	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtgagcttatagatgaaGaagaatgcagagctcgaatt	14	10	13	4	1	0	6	0	2	0	4	1	7	0	6	0	1	3	3	0	1	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr5:176709508G>T	uc003mfr.3	+	19	6073	c.5935G>T	c.(5935-5937)GAA>TAA	p.E1979*	NSD1_uc003mft.3_Nonsense_Mutation_p.E1710*|NSD1_uc011dfx.1_Nonsense_Mutation_p.E1627*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1979	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TATAGATGAAGAAGAATGCAG	0.378			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			33	65					5.91797e-21	8.6666e-21	1	0	T	176709508	T	T	176709508	4	4	136	1	0	0	0	0	0	1	0	0	10723	943	33	2	6005	2	NSD1	5	176709508	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	26012956	176709508	4205752	169	24205											
NRN1	51299	broad.mit.edu	37	chr6	5999396	5999396	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgccccttcctggcaatccGtaagggctgtgaccgtgcag	6	9	12	14	3	0	1	0	1	0	0	3	1	2	1	5	2	1	4	5	2	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:5999396G>T	uc003mwu.2	-	3	893	c.242C>A	c.(241-243)ACG>AAG	p.T81K	NRN1_uc003mwt.2_Missense_Mutation_p.T107K	NM_016588	NP_057672	Q9NPD7	NRN1_HUMAN	neuritin precursor	81						anchored to membrane|plasma membrane					0	Ovarian(93;0.0816)	all_hematologic(90;0.151)		OV - Ovarian serous cystadenocarcinoma(45;0.00415)		CTGGCAATCCGTAAGGGCTGT	0.517													12	57					7.93312e-07	9.33842e-07	1	0	T	5999396	T	T	5999396	3	4	136	1	0	0	0	0	1	0	0	0	10712	1145	40	3	190	3	NRN1	6	5999396	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08		5999396	165115671	170	24206											
PHACTR1	221692	broad.mit.edu	37	chr6	13053694	13053694	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaagtaagtttgccaacctGggaaggattttcaagccttg	12	11	11	7	0	1	1	1	0	0	1	1	3	1	3	3	2	3	2	3	2	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:13053694G>A	uc010jpc.2	+	5	680	c.348G>A	c.(346-348)CTG>CTA	p.L116L	PHACTR1_uc011dir.1_Silent_p.L116L|PHACTR1_uc003nag.1_Silent_p.L116L|PHACTR1_uc003nah.1_Silent_p.L116L	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	116						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TTGCCAACCTGGGAAGGATTT	0.507													8	25					0	0	0	0	A	13053694	A	A	13053694	2	1	136	1	0	0	0	0	0	0	0	1	11864	1335	47	4		4	PHACTR1	6	13053694	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	7054298	13053694	158061373	171	24207											
JARID2	3720	broad.mit.edu	37	chr6	15497018	15497018	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tggcaaggcggacagcgcctCctgtgaaaatcgttctacct	9	9	11	12	3	1	1	0	1	1	0	3	2	2	2	3	3	2	2	3	3	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:15497018C>G	uc003nbj.2	+	7	1806	c.1562C>G	c.(1561-1563)TCC>TGC	p.S521C	JARID2_uc011diu.1_Missense_Mutation_p.S385C|JARID2_uc011div.1_Missense_Mutation_p.S349C|JARID2_uc011diw.1_Missense_Mutation_p.S483C	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	521					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				GACAGCGCCTCCTGTGAAAAT	0.677													13	41					0	0	0	0	G	15497018	G	G	15497018	3	3	136	1	0	0	0	0	1	0	0	0	7984	855	30	2	1588	2	JARID2	6	15497018	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2443324	15497018	155618049	172	24208											
HIST1H3C	8352	broad.mit.edu	37	chr6	26045742	26045742	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagcgctccggccaccggtgGcgtgaagaaacctcatcgct	8	6	13	14	5	1	2	1	1	0	1	3	3	2	2	4	3	2	2	4	3	2	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:26045742G>T	uc003nfv.2	+	1	104	c.104G>T	c.(103-105)GGC>GTC	p.G35V	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	35					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GCCACCGGTGGCGTGAAGAAA	0.627													15	66					0.000219431	0.000244781	1	0	T	26045742	T	T	26045742	3	4	136	1	0	0	0	0	1	0	0	0	7196	1203	42	4	106	4	HIST1H3C	6	26045742	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	10548724	26045742	145069325	173	24209											
HIST1H3C	8352	broad.mit.edu	37	chr6	26046019	26046019	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgcccaaagatatccagctGgcacgtcgcatccgtgggga	10	7	12	12	3	0	1	0	0	0	1	3	2	2	2	3	3	2	3	3	3	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:26046019G>T	uc003nfv.2	+	1	381	c.381G>T	c.(379-381)CTG>CTT	p.L127L	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	127					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						ATATCCAGCTGGCACGTCGCA	0.502													22	47					1.22574e-08	1.51805e-08	1	0	T	26046019	T	T	26046019	2	4	136	1	0	0	0	0	0	0	0	1	7196	1335	47	4		4	HIST1H3C	6	26046019	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	277	26046019	145069048	174	24210											
HIST1H4K	8362	broad.mit.edu	37	chr6	27799255	27799255	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagtactttacggtggcgCttagcgccgcctttgccaag	6	10	12	13	5	0	0	0	0	0	0	0	0	0	0	3	2	4	3	3	2	4	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:27799255C>A	uc003njr.2	-	1	51	c.51G>T	c.(49-51)AAG>AAT	p.K17N		NM_003541	NP_003532	P62805	H4_HUMAN	histone cluster 1, H4k	17					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						TACGGTGGCGCTTAGCGCCGC	0.642													11	107					6.44725e-10	8.23224e-10	1	0	A	27799255	A	A	27799255	3	1	136	1	0	0	0	0	1	0	0	0	7214	796	28	4	264	4	HIST1H4K	6	27799255	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1753236	27799255	143315812	175	24211											
COL11A2	1302	broad.mit.edu	37	chr6	33133582	33133582	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagtggctggatcacctcGcctgggggaccctgggtgca	5	7	17	12	1	1	0	1	0	0	0	2	2	1	2	3	6	1	3	3	6	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:33133582G>T	uc003ocx.1	-	63	4722	c.4494C>A	c.(4492-4494)GGC>GGA	p.G1498G	COL11A2_uc010jul.1_Silent_p.G68G|COL11A2_uc003ocy.1_Silent_p.G1412G|COL11A2_uc003ocz.1_Silent_p.G1391G	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1498	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GGATCACCTCGCCTGGGGGAC	0.627													17	69					6.94344e-10	8.81119e-10	1	0	T	33133582	T	T	33133582	2	4	136	1	0	0	0	0	0	0	0	1	3683	1074	38	3		3	COL11A2	6	33133582	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	5334327	33133582	137981485	176	24212											
DNAH8	1769	broad.mit.edu	37	chr6	38867649	38867649	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagattggcctcttttattgCtggctatcaaatattccaga	11	15	7	8	0	2	2	1	0	1	2	3	2	3	2	2	2	1	2	2	2	5	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:38867649C>A	uc003ooe.1	+	60	9110	c.8510C>A	c.(8509-8511)GCT>GAT	p.A2837D		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TCTTTTATTGCTGGCTATCAA	0.343													4	18					2.56e-06	2.97944e-06	1	0	A	38867649	A	A	38867649	3	1	136	1	0	0	0	0	1	0	0	0	4629	797	28	4	8740	4	DNAH8	6	38867649	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5734067	38867649	132247418	177	24213											
LRFN2	57497	broad.mit.edu	37	chr6	40400710	40400710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtccgccggtcaatatcaGggggtacaaagagcagcccc	10	6	12	13	2	2	1	2	0	0	1	3	1	3	1	4	3	3	2	4	3	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:40400710G>A	uc003oph.1	-	2	608	c.143C>T	c.(142-144)CCT>CTT	p.P48L		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	48	LRRNT.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					GTCAATATCAGGGGGTACAAA	0.612													17	54					0	0	0	0	A	40400710	A	A	40400710	3	1	136	1	0	0	0	0	1	0	0	0	8988	1000	35	4	2234	4	LRFN2	6	40400710	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1533061	40400710	130714357	178	24214											
ENPP5	59084	broad.mit.edu	37	chr6	46135435	46135435	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcccatgtcatcagggtCttcccaatagagaagaccaa	12	8	10	11	0	3	2	2	0	1	2	4	3	4	2	3	2	0	0	3	2	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:46135435C>A	uc003oxz.1	-	2	773	c.565G>T	c.(565-567)GAC>TAC	p.D189Y	ENPP5_uc003oya.1_Missense_Mutation_p.D189Y|ENPP5_uc011dvz.1_Missense_Mutation_p.D95Y|ENPP5_uc010jzc.1_Missense_Mutation_p.D189Y	NM_021572	NP_067547	Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	189						extracellular region|integral to membrane	hydrolase activity				0						TCATCAGGGTCTTCCCAATAG	0.418													27	61					3.6726e-16	5.135e-16	1	0	A	46135435	A	A	46135435	3	1	136	1	0	0	0	0	1	0	0	0	5157	913	32	2	880	2	ENPP5	6	46135435	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5734725	46135435	124979632	179	24215											
RCAN2	10231	broad.mit.edu	37	chr6	46214500	46214500	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttacctggtcctagtttggCcacagcatagaggaggtcat	9	11	11	10	0	1	1	1	0	0	1	2	2	2	2	3	4	2	2	3	4	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:46214500C>T	uc003oyb.1	-	3	733	c.418G>A	c.(418-420)GCC>ACC	p.A140T	RCAN2_uc003oyc.1_Missense_Mutation_p.A186T|RCAN2_uc003oyd.1_Missense_Mutation_p.A186T	NM_005822	NP_005813	Q14206	RCAN2_HUMAN	Down syndrome critical region gene 1-like 1	140					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding				0						CCTAGTTTGGCCACAGCATAG	0.493													8	31					0	0	0	0	T	46214500	T	T	46214500	3	4	136	1	0	0	0	0	1	0	0	0	13234	739	26	4	183	4	RCAN2	6	46214500	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	79065	46214500	124900567	180	24216											
GPR111	222611	broad.mit.edu	37	chr6	47649740	47649740	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacaaagacagagatcacctAtttacgccatgtgtgcattg	13	10	9	9	1	1	2	1	0	0	2	1	4	1	2	2	0	2	1	2	0	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:47649740A>G	uc010jzj.1	+	6	1446	c.1445A>G	c.(1444-1446)TAT>TGT	p.Y482C	GPR111_uc010jzk.1_Missense_Mutation_p.Y414C|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	482	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GAGATCACCTATTTACGCCAT	0.463													15	60					0	0	0	0	G	47649740	G	G	47649740	3	3	136	1	0	0	0	0	1	0	0	0	6666	449	16	5	1259	5	GPR111	6	47649740	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	1435240	47649740	123465327	181	24217											
DST	667	broad.mit.edu	37	chr6	56489356	56489356	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccagcctcttcaatgaaTcaccagcaaatttaatatat	14	13	3	11	0	3	1	2	1	1	0	4	1	4	1	3	0	2	1	3	0	6	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:56489356T>C	uc003pdf.2	-	35	4830	c.4802A>G	c.(4801-4803)GAT>GGT	p.D1601G	DST_uc003pcz.3_Missense_Mutation_p.D1423G|DST_uc011dxj.1_Missense_Mutation_p.D1452G|DST_uc011dxk.1_Missense_Mutation_p.D1463G|DST_uc003pcy.3_Missense_Mutation_p.D1097G|DST_uc003pdb.2_Missense_Mutation_p.D1097G|DST_uc003pdc.3_Missense_Mutation_p.D1097G|DST_uc003pdd.3_Missense_Mutation_p.D1097G	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTTCAATGAATCACCAGCAAA	0.393													8	35					0	0	0	0	C	56489356	C	C	56489356	3	2	136	1	0	0	0	0	1	0	0	0	4805	1435	50	5	17117	5	DST	6	56489356	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	8839616	56489356	114625711	182	24218											
PRIM2	5558	broad.mit.edu	37	chr6	57512689	57512689	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggactagaggattactttaGtgaagattcttaggcagttt	12	14	11	4	0	1	3	0	1	1	2	1	5	1	5	0	3	1	2	0	3	5	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:57512689G>T	uc003pdx.2	+	15	1604	c.1517G>T	c.(1516-1518)AGT>ATT	p.S506I		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	506					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		GATTACTTTAGTGAAGATTCT	0.343													39	278					4.07013e-28	6.1802e-28	1	0	T	57512689	T	T	57512689	3	4	136	1	0	0	0	0	1	0	0	0	12553	1029	36	4	1567	4	PRIM2	6	57512689	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1023333	57512689	113602378	183	24219											
COL9A1	1297	broad.mit.edu	37	chr6	70952405	70952405	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatcccactggtcctaatTctcctctactgccctgtaaa	8	12	7	14	0	2	0	0	0	2	0	5	1	4	1	4	2	2	1	4	2	4	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:70952405T>A	uc003pfg.3	-	29	2045	c.1886A>T	c.(1885-1887)GAA>GTA	p.E629V	COL9A1_uc003pfe.3_Missense_Mutation_p.E202V|COL9A1_uc003pff.3_Missense_Mutation_p.E386V	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	629	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						TGGTCCTAATTCTCCTCTACT	0.348													21	48					0	0	0	0	A	70952405	A	A	70952405	3	1	136	1	0	0	0	0	1	0	0	0	3722	1783	62	5	919	5	COL9A1	6	70952405	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	13439716	70952405	100162662	184	24220											
FILIP1	27145	broad.mit.edu	37	chr6	76023776	76023776	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctttagtaagtcaacactgCagcttaattcagaggatttt	12	15	7	7	0	3	1	2	0	1	1	3	2	3	2	0	1	3	3	0	1	4	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:76023776C>T	uc003pia.2	-	5	2145	c.1772G>A	c.(1771-1773)TGC>TAC	p.C591Y	FILIP1_uc003phy.1_Missense_Mutation_p.C591Y|FILIP1_uc003phz.2_Missense_Mutation_p.C492Y|FILIP1_uc010kbe.2_Missense_Mutation_p.C594Y|FILIP1_uc003pib.1_Missense_Mutation_p.C343Y	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	591	Potential.									skin(3)|ovary(1)	4						GTCAACACTGCAGCTTAATTC	0.388													37	119					0	0	0	0	T	76023776	T	T	76023776	3	4	136	1	0	0	0	0	1	0	0	0	5926	710	25	4	1877	4	FILIP1	6	76023776	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5071371	76023776	95091291	185	24221											
SNX14	57231	broad.mit.edu	37	chr6	86256905	86256905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cataaaacgaaataaaagatCttgttgctctctgatttgct	14	14	6	7	1	2	2	0	1	2	1	3	3	2	2	0	0	3	3	0	0	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:86256905C>T	uc003pkr.2	-	12	1226	c.1033G>A	c.(1033-1035)GAT>AAT	p.D345N	SNX14_uc003pkp.2_Missense_Mutation_p.D208N|SNX14_uc003pkq.2_5'UTR|SNX14_uc011dzg.1_Missense_Mutation_p.D293N|SNX14_uc003pks.2_Missense_Mutation_p.D301N|SNX14_uc003pkt.2_Missense_Mutation_p.D345N	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	345	RGS.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		AATAAAAGATCTTGTTGCTCT	0.343													6	12					0	0	0	0	T	86256905	T	T	86256905	3	4	136	1	0	0	0	0	1	0	0	0	14949	913	32	2	1879	2	SNX14	6	86256905	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	10233129	86256905	84858162	186	24222											
MDN1	23195	broad.mit.edu	37	chr6	90382061	90382061	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagttttgttagatgtcctGattgcagtctctcaaagcct	9	15	9	8	0	2	3	1	1	1	2	4	3	3	3	2	0	2	3	2	0	2	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:90382061G>C	uc003pnn.1	-	82	13768	c.13652C>G	c.(13651-13653)TCA>TGA	p.S4551*		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4551					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TAGATGTCCTGATTGCAGTCT	0.413													13	50					0	0	0	0	C	90382061	C	C	90382061	4	2	136	1	0	0	0	0	0	1	0	0	9468	1294	45	2	3222	2	MDN1	6	90382061	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4125156	90382061	80733006	187	24223											
BACH2	60468	broad.mit.edu	37	chr6	90718382	90718382	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaccagcgcctgccaaaaaTattcactgcatgcggccagc	12	6	8	15	2	1	0	1	0	0	0	1	0	1	0	4	1	6	1	4	1	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:90718382T>C	uc011eab.1	-	6	991	c.182A>G	c.(181-183)TAT>TGT	p.Y61C	BACH2_uc003pnw.2_Missense_Mutation_p.Y61C|BACH2_uc010kch.2_Missense_Mutation_p.Y61C	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	61	BTB.					nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		CTGCCAAAAATATTCACTGCA	0.478													34	59					0	0	0	0	C	90718382	C	C	90718382	3	2	136	1	0	0	0	0	1	0	0	0	1286	1406	49	5	2359	5	BACH2	6	90718382	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	336321	90718382	80396685	188	24224											
MANEA	79694	broad.mit.edu	37	chr6	96053988	96053988	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatacatagataccagcatcCgtccatggaacacgcaaaac	16	6	7	12	2	0	1	0	0	0	1	2	3	2	2	3	1	5	2	3	1	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:96053988C>A	uc003poo.1	+	5	1236	c.1096C>A	c.(1096-1098)CGT>AGT	p.R366S		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	366	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		TACCAGCATCCGTCCATGGAA	0.418													17	77					7.87624e-14	1.06978e-13	1	0	A	96053988	A	A	96053988	3	1	136	1	0	0	0	0	1	0	0	0	9274	652	23	3	1110	3	MANEA	6	96053988	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5335606	96053988	75061079	189	24225											
GPR63	81491	broad.mit.edu	37	chr6	97247474	97247474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatggtttcaaaactatatCtaagcaatggactgaggtca	14	11	8	8	0	3	1	2	1	1	0	3	2	3	2	1	3	2	2	1	3	6	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:97247474C>T	uc010kcl.2	-	3	612	c.134G>A	c.(133-135)AGA>AAA	p.R45K	GPR63_uc003pou.2_Missense_Mutation_p.R45K	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	45	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AAAACTATATCTAAGCAATGG	0.453													10	55					0	0	0	0	T	97247474	T	T	97247474	3	4	136	1	0	0	0	0	1	0	0	0	6742	913	32	2	1129	2	GPR63	6	97247474	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1193486	97247474	73867593	190	24226											
ASCC3	10973	broad.mit.edu	37	chr6	101037825	101037825	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatatgactaagtcataccTctccaatttcaatacagtag	14	12	5	10	0	3	1	2	1	1	0	4	1	3	1	2	0	2	2	2	0	7	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:101037825T>A	uc003pqk.2	-	35	5743	c.5414A>T	c.(5413-5415)GAG>GTG	p.E1805V		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1805					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		AAGTCATACCTCTCCAATTTC	0.343													9	29					0	0	0	0	A	101037825	A	A	101037825	3	1	136	1	0	0	0	0	1	0	0	0	1035	1565	54	5	1226	5	ASCC3	6	101037825	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	3790351	101037825	70077242	191	24227											
ASCC3	10973	broad.mit.edu	37	chr6	101296082	101296082	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcatatcatataaagtacagCaaagatcttctactcttggc	14	12	6	9	0	4	1	1	0	3	1	4	1	4	1	0	1	3	3	0	1	7	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:101296082C>G	uc003pqk.2	-	4	1072	c.743G>C	c.(742-744)TGC>TCC	p.C248S	ASCC3_uc011eai.1_Missense_Mutation_p.C150S|ASCC3_uc003pql.2_Missense_Mutation_p.C248S|ASCC3_uc010kcv.2_Missense_Mutation_p.C248S	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TAAAGTACAGCAAAGATCTTC	0.318													9	50					0	0	0	0	G	101296082	G	G	101296082	3	3	136	1	0	0	0	0	1	0	0	0	1035	710	25	4	6021	4	ASCC3	6	101296082	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	258257	101296082	69818985	192	24228											
POPDC3	64208	broad.mit.edu	37	chr6	105606590	105606590	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatttctttctcctccaagAcacatatcgacaatcagttt	12	15	3	11	1	3	1	1	0	2	1	6	2	4	1	2	0	0	1	2	0	4	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:105606590A>T	uc003prb.2	-	4	1033	c.631T>A	c.(631-633)TCT>ACT	p.S211T	uc003pqz.2_Intron|POPDC3_uc003pra.2_RNA	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	211						integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				CTCCTCCAAGACACATATCGA	0.403													61	163					0	0	0	0	T	105606590	T	T	105606590	3	4	136	1	0	0	0	0	1	0	0	0	12311	275	10	5	248	5	POPDC3	6	105606590	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	4310508	105606590	65508477	193	24229											
RTN4IP1	84816	broad.mit.edu	37	chr6	107070746	107070746	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacattccatcaccacgcCagagacatcccgacccagag	12	4	6	19	2	1	2	1	0	0	2	3	4	3	2	6	0	0	0	6	0	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:107070746C>T	uc003prj.2	-	2	850	c.373G>A	c.(373-375)GGC>AGC	p.G125S	RTN4IP1_uc010kdd.2_Missense_Mutation_p.G125S|RTN4IP1_uc003prk.2_Missense_Mutation_p.G25S	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	125						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		ATCACCACGCCAGAGACATCC	0.428													9	29					0	0	0	0	T	107070746	T	T	107070746	3	4	136	1	0	0	0	0	1	0	0	0	13794	594	21	4	849	4	RTN4IP1	6	107070746	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1464156	107070746	64044321	194	24230											
ROS1	6098	broad.mit.edu	37	chr6	117710810	117710810	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgcgaggtaggatgagatGggaagcagagccatccagaa	14	5	16	6	1	0	3	0	1	0	3	1	8	1	5	2	3	3	2	2	3	3	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:117710810G>T	uc003pxp.1	-	12	1661	c.1462C>A	c.(1462-1464)CAT>AAT	p.H488N	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	488	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AGGATGAGATGGGAAGCAGAG	0.433			T	GOPC|ROS1	glioblastoma|NSCLC								21	48					2.54575e-18	3.68448e-18	1	0	T	117710810	T	T	117710810	3	4	136	1	0	0	0	0	1	0	0	0	13596	1348	47	4	5709	4	ROS1	6	117710810	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	10640064	117710810	53404257	195	24231											
C6orf204	387119	broad.mit.edu	37	chr6	118887324	118887324	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtttcccaatgtttgcaTgaggcttgtactccattttg	6	17	10	8	0	0	1	0	1	0	0	2	1	2	1	2	2	2	5	2	2	2	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:118887324T>A	uc003pxz.1	-	3	976	c.388A>T	c.(388-390)ATG>TTG	p.M130L	C6orf204_uc003pya.1_Missense_Mutation_p.M133L|C6orf204_uc003pyb.2_Missense_Mutation_p.M130L|C6orf204_uc011ebj.1_Missense_Mutation_p.M28L|C6orf204_uc003pyc.2_Missense_Mutation_p.M133L|C6orf204_uc011ebl.1_Missense_Mutation_p.M28L	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	130						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		AATGTTTGCATGAGGCTTGTA	0.478													15	82					0	0	0	0	A	118887324	A	A	118887324	3	1	136	1	0	0	0	0	1	0	0	0	2363	1464	51	5	2127	5	C6orf204	6	118887324	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	1176514	118887324	52227743	196	24232											
TRDN	10345	broad.mit.edu	37	chr6	123687329	123687329	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttggctcgttcagtttcTgcaagttcagatattaaagg	9	16	9	7	1	4	1	2	0	2	1	5	1	4	1	0	2	1	5	0	2	4	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:123687329T>C	uc003pzj.1	-	20	1296	c.1274_splice	c.e20-1	p.K425_splice	TRDN_uc003pzk.1_Splice_Site_p.K426_splice|TRDN_uc003pzl.1_Splice_Site_p.K426_splice|TRDN_uc010kem.1_Splice_Site	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin						muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		GTTCAGTTTCTGCAAGTTCAG	0.308													5	25					0	0	0	0	C	123687329	C	C	123687329	5	2	136	1	0	0	0	0	0	0	1	0	16535	1594	55	5	1005	5	TRDN	6	123687329	Splice_Site	SNP	T	TCGA-CR-7364-01A-11D-2012-08	4800005	123687329	47427738	197	24233											
LAMA2	3908	broad.mit.edu	37	chr6	129380955	129380955	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccgattacaaatgctattGatggaaagaacacttggtgg	14	10	10	7	1	0	2	0	1	0	1	0	4	0	3	1	3	3	1	1	3	5	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:129380955G>A	uc003qbn.2	+	3	415	c.310G>A	c.(310-312)GAT>AAT	p.D104N	LAMA2_uc003qbo.2_Missense_Mutation_p.D104N	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	104	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AAATGCTATTGATGGAAAGAA	0.358													10	23					0	0	0	0	A	129380955	A	A	129380955	3	1	136	1	0	0	0	0	1	0	0	0	8646	1290	45	2	320	2	LAMA2	6	129380955	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	5693626	129380955	41734112	198	24234											
TMEM200A	114801	broad.mit.edu	37	chr6	130762603	130762603	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcccgtcagcacagtgctaCcaaggaataattccattggg	12	8	10	11	1	1	0	1	0	0	0	2	1	2	1	3	2	4	2	3	2	4	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:130762603C>G	uc003qca.2	+	3	1907	c.1036C>G	c.(1036-1038)CCA>GCA	p.P346A	TMEM200A_uc010kfh.2_Missense_Mutation_p.P346A|TMEM200A_uc010kfi.2_Missense_Mutation_p.P346A|TMEM200A_uc003qcb.2_Missense_Mutation_p.P346A	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	346	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CACAGTGCTACCAAGGAATAA	0.517													13	50					0	0	0	0	G	130762603	G	G	130762603	3	3	136	1	0	0	0	0	1	0	0	0	16189	507	18	4	1038	4	TMEM200A	6	130762603	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1381648	130762603	40352464	199	24235											
CTGF	1490	broad.mit.edu	37	chr6	132270617	132270617	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	actccacagaatttagctcgGtatgtcttcatgctggtgca	9	13	9	10	1	2	1	1	0	1	1	4	1	3	1	1	2	3	4	1	2	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:132270617G>A	uc003qcz.2	-	5	1043	c.837C>T	c.(835-837)TAC>TAT	p.Y279Y		NM_001901	NP_001892	P29279	CTGF_HUMAN	connective tissue growth factor precursor	279	CTCK.|Heparin-binding.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding				0	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		ATTTAGCTCGGTATGTCTTCA	0.537													83	307					0	0	0	0	A	132270617	A	A	132270617	2	1	136	1	0	0	0	0	0	0	0	1	4025	1256	44	4		4	CTGF	6	132270617	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1508014	132270617	38844450	200	24236											
OLIG3	167826	broad.mit.edu	37	chr6	137815175	137815175	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catcttctgcatcatatcgcCctgcgtggacgagaccgagt	8	10	10	13	4	3	1	1	0	2	1	4	4	3	2	2	1	2	1	2	1	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:137815175C>T	uc003qhp.1	-	1	357	c.133G>A	c.(133-135)GGC>AGC	p.G45S		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	45					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		ATCATATCGCCCTGCGTGGAC	0.512													31	112					0	0	0	0	T	137815175	T	T	137815175	3	4	136	1	0	0	0	0	1	0	0	0	10916	623	22	4	689	4	OLIG3	6	137815175	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5544558	137815175	33299892	201	24237											
SYNE1	23345	broad.mit.edu	37	chr6	152647563	152647563	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccagggtggctaccaggCtgtggagctcctccaggtta	6	9	15	11	0	0	0	0	0	0	0	3	1	3	1	4	6	2	4	4	6	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:152647563C>A	uc010kiw.2	-	79	15763	c.15161G>T	c.(15160-15162)AGC>ATC	p.S5054I	SYNE1_uc003qot.3_Missense_Mutation_p.S4983I|SYNE1_uc003qou.3_Missense_Mutation_p.S5054I|SYNE1_uc010kiz.2_Missense_Mutation_p.S809I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5054	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGCTACCAGGCTGTGGAGCTC	0.522										HNSCC(10;0.0054)			20	71					3.51602e-12	4.63305e-12	1	0	A	152647563	A	A	152647563	3	1	136	1	0	0	0	0	1	0	0	0	15511	797	28	4	11577	4	SYNE1	6	152647563	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	14832388	152647563	18467504	202	24238											
CNKSR3	154043	broad.mit.edu	37	chr6	154727611	154727611	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctggaatggaatcgtGgcgctgctgtggagatctga	7	11	14	9	2	1	2	0	1	1	1	4	5	3	4	2	4	1	2	2	4	2	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:154727611G>A	uc003qpy.2	-	13	2050	c.1545C>T	c.(1543-1545)GCC>GCT	p.A515A		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	515	DUF1170.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		ATGGAATCGTGGCGCTGCTGT	0.582													32	70					0	0	0	0	A	154727611	A	A	154727611	2	1	136	1	0	0	0	0	0	0	0	1	3623	1335	47	4		4	CNKSR3	6	154727611	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2080048	154727611	16387456	203	24239											
NOX3	50508	broad.mit.edu	37	chr6	155718053	155718053	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacatcttttgaagtgtccTcgagagagctttaggtccac	9	12	10	10	1	1	2	0	1	1	1	4	4	3	2	2	1	1	2	2	1	2	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:155718053T>C	uc003qqm.2	-	13	1727	c.1624A>G	c.(1624-1626)AGG>GGG	p.R542G		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	542	Cytoplasmic (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		TGAAGTGTCCTCGAGAGAGCT	0.468													28	69					0	0	0	0	C	155718053	C	C	155718053	3	2	136	1	0	0	0	0	1	0	0	0	10611	1550	54	5	86	5	NOX3	6	155718053	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	990442	155718053	15397014	204	24240											
LPA	4018	broad.mit.edu	37	chr6	161020587	161020587	+	Frame_Shift_Del	DEL	A	-	-																															gtgtggtgtcatagatgaccAagcttggcaagttcttcctg																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:161020587delA	uc003qtl.2	-	21	3352	c.3232delT	c.(3232-3234)TGGfs	p.W1078fs		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3586	Kringle 32.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ATAGATGACCAAGCTTGGCAA	0.502													---	---	---								-	161020587	-	-	161020587	7	5	136	1	0	1	0	1	0	0	0	0	8953	130	5	0	2970	0	LPA	6	161020587	Frame_Shift_Del	DEL	A	TCGA-CR-7364-01A-11D-2012-08	5302534	161020587	10094480	205	24241											
PLG	5340	broad.mit.edu	37	chr6	161128796	161128796	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaaacaggaagtcctccAtaatcattaggatgagagat	16	9	9	7	0	1	3	1	2	0	1	3	6	3	5	2	2	1	0	2	2	5	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:161128796A>G	uc003qtm.3	+	3	313	c.250A>G	c.(250-252)ATA>GTA	p.I84V		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	84	PAN.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GAAGTCCTCCATAATCATTAG	0.274													47	143					0	0	0	0	G	161128796	G	G	161128796	3	3	136	1	0	0	0	0	1	0	0	0	12141	217	8	5	260	5	PLG	6	161128796	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	108209	161128796	9986271	206	24242											
PDE10A	10846	broad.mit.edu	37	chr6	165801917	165801917	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtccaggtcatgacacAgacacgcaatcagcagtcct	11	8	10	12	1	2	2	2	1	0	1	4	2	4	2	2	2	1	2	2	2	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr6:165801917A>G	uc003qun.2	-	18	1893	c.1652T>C	c.(1651-1653)CTG>CCG	p.L551P	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.L481P|PDE10A_uc003quo.2_Missense_Mutation_p.L561P	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	551					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GTCATGACACAGACACGCAAT	0.488													25	66					0	0	0	0	G	165801917	G	G	165801917	3	3	136	1	0	0	0	0	1	0	0	0	11684	188	7	5	711	5	PDE10A	6	165801917	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	4673121	165801917	5313150	207	24243											
GPER	2852	broad.mit.edu	37	chr7	1132336	1132336	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcctaaaccccctcatctaCagctttctcggggagacctt	8	11	7	15	1	3	1	1	0	2	1	4	2	3	1	4	2	4	1	4	2	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:1132336C>T	uc010ksd.1	+	2	1361	c.972C>T	c.(970-972)TAC>TAT	p.Y324Y	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPER_uc003sjz.1_Silent_p.Y324Y|GPER_uc003ska.1_Silent_p.Y324Y|GPER_uc003skb.2_Silent_p.Y324Y	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	324	Helical; Name=7; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		CCCTCATCTACAGCTTTCTCG	0.587													55	85					0	0	0	0	T	1132336	T	T	1132336	2	4	136	1	0	0	0	0	0	0	0	1	6645	489	17	4		4	GPER	7	1132336	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08		1132336	158006327	208	24244											
FBXL18	80028	broad.mit.edu	37	chr7	5541042	5541042	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagcacgacattgcgcgcCatggagtccaggaggttctt	8	9	12	12	3	1	0	0	0	1	0	3	3	3	2	3	3	2	2	3	3	0	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:5541042C>G	uc003soo.2	-	3	952	c.858G>C	c.(856-858)ATG>ATC	p.M286I	FBXL18_uc003son.3_Missense_Mutation_p.M286I	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	286										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		CATTGCGCGCCATGGAGTCCA	0.602													21	26					0	0	0	0	G	5541042	G	G	5541042	3	3	136	1	0	0	0	0	1	0	0	0	5746	594	21	4	1310	4	FBXL18	7	5541042	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	4408706	5541042	153597621	209	24245											
PMS2	5395	broad.mit.edu	37	chr7	6042083	6042083	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	accaggattaatttactgtaCcttcttaatattcctttgaa	12	17	4	8	0	1	1	0	1	1	0	2	2	2	2	3	1	2	1	3	1	6	9			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:6042083C>T	uc003spl.2	-	5	624	c.537_splice	c.e5+1	p.K179_splice	PMS2_uc003spj.2_Splice_Site_p.K73_splice|PMS2_uc003spk.2_Splice_Site_p.K44_splice|PMS2_uc011jwl.1_Splice_Site_p.K44_splice|PMS2_uc010ktg.2_Splice_Site|PMS2_uc010kte.2_Splice_Site_p.K179_splice|PMS2_uc010ktf.1_Splice_Site_p.K179_splice	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform						mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		ATTTACTGTACCTTCTTAATA	0.408			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				8	146					0	0	0	0	T	6042083	T	T	6042083	5	4	136	1	0	0	0	0	0	0	1	0	12198	521	18	4	2094	4	PMS2	7	6042083	Splice_Site	SNP	C	TCGA-CR-7364-01A-11D-2012-08	501041	6042083	153096580	210	24246											
IGF2BP3	10643	broad.mit.edu	37	chr7	23383461	23383461	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctggattatacagcgtcAattcctgcaatctgcagaat	11	13	8	9	1	3	1	1	0	2	1	4	2	4	2	1	1	4	3	1	1	5	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:23383461A>T	uc003swg.2	-	9	1219	c.953T>A	c.(952-954)TTG>TAG	p.L318*	IGF2BP3_uc003swf.2_Intron	NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	318	KH 2.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						ATACAGCGTCAATTCCTGCAA	0.383													27	27					0	0	0	0	T	23383461	T	T	23383461	4	4	136	1	0	0	0	0	0	1	0	0	7614	131	5	5	814	5	IGF2BP3	7	23383461	Nonsense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	17341378	23383461	135755202	211	24247											
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26232884	26232885	+	Frame_Shift_Ins	INS	-	C	C																															aattacctccaccatatggtINSccccccatgttcctgctacc																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:26232884_26232885insC	uc003sxr.3	-	10	1202_1203	c.986_987insG	c.(985-987)GGAfs	p.G329fs	HNRNPA2B1_uc003sxs.3_Frame_Shift_Ins_p.G317fs	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	329	Gly-rich.|Nuclear targeting sequence (By similarity).				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CACCATATGGTCCCCCCATGTT	0.361			T	ETV1	prostate								---	---	---								C	26232885	C	C	26232884	7	5	136	1	0	1	1	0	0	0	0	0	7298	1654	58	0	82	0	HNRNPA2B1	7	26232884	Frame_Shift_Ins	INS	-	TCGA-CR-7364-01A-11D-2012-08	2849423	26232884	132905779	212	24248											
CREB5	9586	broad.mit.edu	37	chr7	28857725	28857725	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaaatgaggtggcccagcTgaaacagttgttgttaacac	14	9	11	7	0	0	2	0	2	0	0	0	3	0	2	1	2	3	4	1	2	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:28857725T>A	uc003szq.2	+	10	1682	c.1292T>A	c.(1291-1293)CTG>CAG	p.L431Q	CREB5_uc003szo.2_Missense_Mutation_p.L398Q|CREB5_uc003szr.2_Missense_Mutation_p.L424Q|CREB5_uc003szs.2_Missense_Mutation_p.L292Q	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	431	Leucine-zipper.				positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GTGGCCCAGCTGAAACAGTTG	0.388													20	78					0	0	0	0	A	28857725	A	A	28857725	3	1	136	1	0	0	0	0	1	0	0	0	3875	1580	55	5	1381	5	CREB5	7	28857725	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	2624841	28857725	130280938	213	24249											
CPVL	54504	broad.mit.edu	37	chr7	29152338	29152338	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctgagctgggaagaaccaGaagaagaggttgctgttgta	13	8	14	6	0	0	5	0	1	0	4	0	6	0	6	2	2	3	5	2	2	5	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:29152338G>C	uc003szv.2	-	3	389	c.270C>G	c.(268-270)TTC>TTG	p.F90L	CPVL_uc003szw.2_Missense_Mutation_p.F90L|CPVL_uc003szx.2_Missense_Mutation_p.F90L	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	90					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						GGAAGAACCAGAAGAAGAGGT	0.493													34	37					0	0	0	0	C	29152338	C	C	29152338	3	2	136	1	0	0	0	0	1	0	0	0	3850	933	33	2	1204	2	CPVL	7	29152338	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	294613	29152338	129986325	214	24250											
C7orf16	10842	broad.mit.edu	37	chr7	31735160	31735160	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaaaatgtacaggccaccCtgaatgttgagtcagaccaa	16	7	9	9	0	1	3	1	2	0	1	1	4	1	3	3	1	1	2	3	1	6	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:31735160C>A	uc003tcl.2	+	3	318	c.160C>A	c.(160-162)CTG>ATG	p.L54M	C7orf16_uc011kaf.1_Intron	NM_006658	NP_006649	O96001	GSUB_HUMAN	G-substrate isoform 1	54					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction				ovary(2)|central_nervous_system(1)	3			GBM - Glioblastoma multiforme(11;0.216)			ACAGGCCACCCTGAATGTTGA	0.423													62	86					8.4772e-36	1.32296e-35	1	0	A	31735160	A	A	31735160	3	1	136	1	0	0	0	0	1	0	0	0	2389	680	24	4	166	4	C7orf16	7	31735160	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2582822	31735160	127403503	215	24251											
BMPER	168667	broad.mit.edu	37	chr7	34125437	34125437	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgcatctcaagggcaagcTctgtggtctttgtggcaact	7	11	12	11	1	3	0	1	0	3	0	4	0	3	0	1	3	2	4	1	3	3	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:34125437T>G	uc011kap.1	+	13	1592	c.1478T>G	c.(1477-1479)CTC>CGC	p.L493R		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	493	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						AAGGGCAAGCTCTGTGGTCTT	0.443													32	50					0	0	0	0	G	34125437	G	G	34125437	3	3	136	1	0	0	0	0	1	0	0	0	1471	1551	54	5	1528	5	BMPER	7	34125437	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	2390277	34125437	125013226	216	24252											
MYO1G	64005	broad.mit.edu	37	chr7	45005293	45005293	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagcacagcagggggcagcGgccacacaaggtcacgcccg	10	1	15	15	3	1	0	1	0	0	0	1	0	1	0	2	4	3	4	2	4	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:45005293G>A	uc003tmh.2	-	17	2468	c.2324C>T	c.(2323-2325)CCG>CTG	p.P775L	MYO1G_uc003tmf.2_Missense_Mutation_p.P218L|MYO1G_uc003tmg.2_Missense_Mutation_p.P537L|MYO1G_uc010kym.2_Missense_Mutation_p.P660L	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	775						myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						AGGGGGCAGCGGCCACACAAG	0.637													44	43					0	0	0	0	A	45005293	A	A	45005293	3	1	136	1	0	0	0	0	1	0	0	0	10127	1116	39	1	756	1	MYO1G	7	45005293	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	10879856	45005293	114133370	217	24253											
HUS1	3364	broad.mit.edu	37	chr7	48016391	48016391	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcctaggaatcacctttatgGggatgtcatgggtcacaatg	10	12	11	8	0	3	0	3	0	0	0	4	2	4	2	2	4	0	0	2	4	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:48016391G>A	uc003tod.1	-	4	531	c.401C>T	c.(400-402)CCC>CTC	p.P134L	HUS1_uc003toe.1_Missense_Mutation_p.P134L|HUS1_uc011kce.1_RNA	NM_004507	NP_004498	O60921	HUS1_HUMAN	HUS1 checkpoint protein	134					DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			ovary(2)|lung(2)|kidney(1)	5		Breast(660;0.00139)				CACCTTTATGGGGATGTCATG	0.413								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					73	101					0	0	0	0	A	48016391	A	A	48016391	3	1	136	1	0	0	0	0	1	0	0	0	7498	1232	43	4	461	4	HUS1	7	48016391	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	3011098	48016391	111122272	218	24254											
ABCA13	154664	broad.mit.edu	37	chr7	48411888	48411888	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaaaacaagtggcatctttGcacacagcaatacctttatt	14	12	6	9	0	1	1	0	1	1	0	1	1	1	1	1	1	4	3	1	1	6	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:48411888G>T	uc003toq.2	+	33	10952	c.10927G>T	c.(10927-10929)GCA>TCA	p.A3643S	ABCA13_uc010kys.1_Missense_Mutation_p.A717S|ABCA13_uc003tos.1_Missense_Mutation_p.A469S	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3643					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TGGCATCTTTGCACACAGCAA	0.458													68	116					2.50483e-33	3.86996e-33	1	0	T	48411888	T	T	48411888	3	4	136	1	0	0	0	0	1	0	0	0	31	1319	46	4	10886	4	ABCA13	7	48411888	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	395497	48411888	110726775	219	24255											
GBAS	2631	broad.mit.edu	37	chr7	56062652	56062652	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggattcttctctcagattgGgcagctgtacatggtgcacc	8	12	11	10	0	3	1	1	0	2	1	4	2	3	2	1	3	3	4	1	3	1	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:56062652G>A	uc003tre.1	+	8	691	c.683G>A	c.(682-684)GGG>GAG	p.G228E	GBAS_uc003trf.1_Missense_Mutation_p.G189E	NM_001483	NP_001474	O75323	NIPS2_HUMAN	nipsnap homolog 2	228						integral to plasma membrane|membrane fraction|mitochondrion	protein binding			central_nervous_system(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCTCAGATTGGGCAGCTGTAC	0.453													34	663					0	0	0	0	A	56062652	A	A	56062652	3	1	136	1	0	0	0	0	1	0	0	0	6304	1232	43	4	713	4	GBAS	7	56062652	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	7650764	56062652	103076011	220	24256											
TBL2	26608	broad.mit.edu	37	chr7	72985558	72985558	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcaaacgagtgcacagccGcggagtggccctttagttcg	10	7	13	11	4	0	0	0	0	0	0	1	2	0	1	2	2	4	3	2	2	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:72985558G>A	uc003tyh.2	-	6	973	c.839C>T	c.(838-840)GCG>GTG	p.A280V	TBL2_uc011kex.1_Missense_Mutation_p.A244V|TBL2_uc010lbg.2_Missense_Mutation_p.A185V|TBL2_uc003tyi.2_Missense_Mutation_p.A115V|TBL2_uc011key.1_Missense_Mutation_p.A151V|TBL2_uc010lbh.2_Missense_Mutation_p.A185V	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	280	WD 5.										0		Lung NSC(55;0.0659)|all_lung(88;0.152)				GTGCACAGCCGCGGAGTGGCC	0.567													15	44					0	0	0	0	A	72985558	A	A	72985558	3	1	136	1	0	0	0	0	1	0	0	0	15708	1087	38	1	512	1	TBL2	7	72985558	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	16922906	72985558	86153105	221	24257											
HGF	3082	broad.mit.edu	37	chr7	81346600	81346600	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtggatttcccgtgtagcaCcagggtccatgagcatcatc	9	10	11	11	1	1	1	1	1	0	0	4	2	3	2	3	2	2	3	3	2	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:81346600C>G	uc003uhl.2	-	11	1518	c.1353G>C	c.(1351-1353)TGG>TGC	p.W451C	HGF_uc003uhm.2_Missense_Mutation_p.W446C	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	451	Kringle 4.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						CCGTGTAGCACCAGGGTCCAT	0.423													15	48					0	0	0	0	G	81346600	G	G	81346600	3	3	136	1	0	0	0	0	1	0	0	0	7124	508	18	4	865	4	HGF	7	81346600	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	8361042	81346600	77792063	222	24258											
PCLO	27445	broad.mit.edu	37	chr7	82764673	82764673	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttctttgggaggggctggCttggacaaagaatctgcctc	7	11	15	8	0	2	1	0	0	2	1	3	3	2	3	1	6	1	3	1	6	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:82764673C>A	uc003uhx.2	-	3	2482	c.2193G>T	c.(2191-2193)AAG>AAT	p.K731N	PCLO_uc003uhv.2_Missense_Mutation_p.K731N	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	677	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GAGGGGCTGGCTTGGACAAAG	0.537													10	43					0.000442599	0.000491071	1	0	A	82764673	A	A	82764673	3	1	136	1	0	0	0	0	1	0	0	0	11637	796	28	4	13344	4	PCLO	7	82764673	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1418073	82764673	76373990	223	24259											
PCLO	27445	broad.mit.edu	37	chr7	82784850	82784850	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtctgctgagctggaggcttAgcaggaccaagaggctgagc	9	7	16	9	0	1	3	0	2	1	1	1	5	1	5	1	4	4	5	1	4	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:82784850A>G	uc003uhx.2	-	2	1396	c.1107T>C	c.(1105-1107)GCT>GCC	p.A369A	PCLO_uc003uhv.2_Silent_p.A369A	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	329	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGGAGGCTTAGCAGGACCAA	0.577													11	36					0	0	0	0	G	82784850	G	G	82784850	2	3	136	1	0	0	0	0	0	0	0	1	11637	407	15	5		5	PCLO	7	82784850	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	20177	82784850	76353813	224	24260											
SEMA3A	10371	broad.mit.edu	37	chr7	83590917	83590917	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaccttctggctaggtgTcatgctattggacatttctt	7	15	9	10	0	3	1	1	0	2	1	3	2	3	2	2	3	1	2	2	3	2	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:83590917T>C	uc003uhz.2	-	17	2401	c.2086A>G	c.(2086-2088)ACA>GCA	p.T696A		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	696					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TGGCTAGGTGTCATGCTATTG	0.438													31	81					0	0	0	0	C	83590917	C	C	83590917	3	2	136	1	0	0	0	0	1	0	0	0	14089	1667	58	5	233	5	SEMA3A	7	83590917	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	806067	83590917	75547746	225	24261											
TECPR1	25851	broad.mit.edu	37	chr7	97874270	97874270	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccactcccagtgcggcgagGgcagtgccaccctgtccagc	6	5	12	18	2	0	0	0	0	0	0	2	1	2	0	5	2	3	1	5	2	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:97874270G>A	uc003upg.2	-	4	540	c.335C>T	c.(334-336)CCC>CTC	p.P112L	TECPR1_uc003uph.1_Missense_Mutation_p.P33L	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	112						integral to membrane	protein binding			pancreas(1)	1						GTGCGGCGAGGGCAGTGCCAC	0.622													8	22					0	0	0	0	A	97874270	A	A	97874270	3	1	136	1	0	0	0	0	1	0	0	0	15809	1232	43	4	3254	4	TECPR1	7	97874270	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	14283353	97874270	61264393	226	24262											
RELN	5649	broad.mit.edu	37	chr7	103194255	103194255	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcgataatgaagtcatcaaCaatccagatttcttctttct	13	15	4	9	1	5	2	2	1	3	1	7	3	6	2	1	0	1	0	1	0	4	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:103194255C>A	uc003vca.2	-	39	5981	c.5821G>T	c.(5821-5823)GTT>TTT	p.V1941F	RELN_uc010liz.2_Missense_Mutation_p.V1941F	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1941					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AAGTCATCAACAATCCAGATT	0.348													11	54					6.40141e-05	7.20596e-05	1	0	A	103194255	A	A	103194255	3	1	136	1	0	0	0	0	1	0	0	0	13285	478	17	4	4669	4	RELN	7	103194255	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5319985	103194255	55944408	227	24263											
RELN	5649	broad.mit.edu	37	chr7	103202352	103202352	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcaatcgcccaggaatcagcCcccacagtgtagttggcctg	9	8	10	14	1	2	0	2	0	0	0	3	1	2	1	4	2	1	2	4	2	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:103202352C>T	uc003vca.2	-	35	5419	c.5259G>A	c.(5257-5259)GGG>GGA	p.G1753G	RELN_uc010liz.2_Silent_p.G1753G	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1753					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGGAATCAGCCCCCACAGTGT	0.478													11	19					0	0	0	0	T	103202352	T	T	103202352	2	4	136	1	0	0	0	0	0	0	0	1	13285	610	22	4		4	RELN	7	103202352	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	8097	103202352	55936311	228	24264											
SLC26A3	1811	broad.mit.edu	37	chr7	107423469	107423469	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaactgctgatctggagaGggcagtactcccagcaaatc	11	8	11	11	0	1	3	0	2	1	1	3	4	2	3	1	2	4	4	1	2	3	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:107423469G>T	uc003ver.2	-	10	1400	c.1189C>A	c.(1189-1191)CTC>ATC	p.L397I	SLC26A3_uc003ves.2_Missense_Mutation_p.L362I	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	397					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						GATCTGGAGAGGGCAGTACTC	0.458													32	87					9.17885e-22	1.36032e-21	1	0	T	107423469	T	T	107423469	3	4	136	1	0	0	0	0	1	0	0	0	14582	1000	35	4	1153	4	SLC26A3	7	107423469	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4221117	107423469	51715194	229	24265											
LAMB4	22798	broad.mit.edu	37	chr7	107696308	107696308	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgatcaaagcacaagtgaCattgaagacaagtagggaat	18	7	10	6	0	1	4	1	3	0	1	1	5	1	5	0	1	1	2	0	1	6	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:107696308C>T	uc010ljo.1	-	25	3608	c.3524G>A	c.(3523-3525)TGT>TAT	p.C1175Y	LAMB4_uc003vey.2_Missense_Mutation_p.C1175Y|LAMB4_uc010ljp.1_Missense_Mutation_p.C144Y	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1175	Domain II.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						GCACAAGTGACATTGAAGACA	0.542													20	75					0	0	0	0	T	107696308	T	T	107696308	3	4	136	1	0	0	0	0	1	0	0	0	8653	478	17	4	1801	4	LAMB4	7	107696308	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	272839	107696308	51442355	230	24266											
ASZ1	136991	broad.mit.edu	37	chr7	117003704	117003704	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaagaaaaccgaatccgcaTatggtaatagctgtcctctt	14	10	8	9	2	1	2	0	0	1	2	3	3	3	2	3	1	2	3	3	1	7	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:117003704T>C	uc003vjb.2	-	13	1437	c.1374A>G	c.(1372-1374)ATA>ATG	p.I458M	ASZ1_uc011kno.1_Missense_Mutation_p.I449M|ASZ1_uc011knp.1_Missense_Mutation_p.I250M	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	458					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CGAATCCGCATATGGTAATAG	0.318													14	40					0	0	0	0	C	117003704	C	C	117003704	3	2	136	1	0	0	0	0	1	0	0	0	1071	1396	49	5	57	5	ASZ1	7	117003704	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	9307396	117003704	42134959	231	24267											
ASB15	142685	broad.mit.edu	37	chr7	123270163	123270163	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agagaatggccagaaatccgCcaaatactaggtaaaaacca	19	5	8	9	1	0	2	0	0	0	2	1	3	1	2	4	2	2	1	4	2	8	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:123270163C>A	uc003vku.1	+	11	1876	c.1584C>A	c.(1582-1584)CGC>CGA	p.R528R	ASB15_uc003vkw.1_Silent_p.R528R	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	528	SOCS box.				intracellular signal transduction					skin(2)|lung(1)	3						CAGAAATCCGCCAAATACTAG	0.353													20	49					5.35267e-07	6.386e-07	1	0	A	123270163	A	A	123270163	2	1	136	1	0	0	0	0	0	0	0	1	1021	726	26	4		4	ASB15	7	123270163	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	6266459	123270163	35868500	232	24268											
ZNF282	8427	broad.mit.edu	37	chr7	148903833	148903833	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtacttctccgaagacGagtggaagaacttggacgaa	12	9	12	8	3	1	2	0	0	1	2	2	7	1	4	1	2	2	1	1	2	5	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr7:148903833G>T	uc003wfm.2	+	3	736	c.631G>T	c.(631-633)GAG>TAG	p.E211*	ZNF282_uc011kun.1_Nonsense_Mutation_p.E211*|ZNF282_uc003wfn.2_Nonsense_Mutation_p.E151*|ZNF282_uc003wfo.2_Nonsense_Mutation_p.E151*	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	211	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CTCCGAAGACGAGTGGAAGAA	0.498													74	174					9.07738e-34	1.40597e-33	1	0	T	148903833	T	T	148903833	4	4	136	1	0	0	0	0	0	1	0	0	17886	1059	37	3	641	3	ZNF282	7	148903833	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	25633670	148903833	10234830	233	24269											
C8orf42	157695	broad.mit.edu	37	chr8	444571	444571	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aacagtgaagtcacttctttCcaacctcggaaacttgctcc	11	11	6	13	1	2	1	1	1	1	0	5	2	4	2	3	1	4	1	3	1	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:444571C>T	uc003wpd.2	-	2	709	c.135G>A	c.(133-135)TGG>TGA	p.W45*	C8orf42_uc011kwg.1_Nonsense_Mutation_p.W45*	NM_175075	NP_778250	Q86YL5	CH042_HUMAN	hypothetical protein LOC157695	45											0		Ovarian(12;0.0481)|Colorectal(14;0.0815)|Hepatocellular(245;0.0968)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;5.16e-14)|OV - Ovarian serous cystadenocarcinoma(5;7.35e-07)|BRCA - Breast invasive adenocarcinoma(11;4.17e-06)|COAD - Colon adenocarcinoma(149;0.0255)		TCACTTCTTTCCAACCTCGGA	0.383													10	30					0	0	0	0	T	444571	T	T	444571	4	4	136	1	0	0	0	0	0	1	0	0	2440	856	30	2	430	2	C8orf42	8	444571	Nonsense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08		444571	145919451	234	24270											
USP17L2	377630	broad.mit.edu	37	chr8	11995836	11995836	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagcagccaatgcctgtgagGgctggatgacatgaccagga	11	6	14	10	0	0	3	0	3	0	0	0	5	0	5	3	3	3	2	3	3	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:11995836G>A	uc003wvc.1	-	1	434	c.434C>T	c.(433-435)CCC>CTC	p.P145L	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	145					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						TGCCTGTGAGGGCTGGATGAC	0.527													39	70					0	0	0	0	A	11995836	A	A	11995836	3	1	136	1	0	0	0	0	1	0	0	0	17116	1232	43	4	1162	4	USP17L2	8	11995836	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	11551265	11995836	134368186	235	24271											
LONRF1	91694	broad.mit.edu	37	chr8	12598387	12598387	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtaaactgattacctttTgtacttgcagctttgcaggt	8	17	9	7	0	0	1	0	1	0	0	0	1	0	1	1	2	6	5	1	2	4	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:12598387T>C	uc003wwd.1	-	3	1022	c.959A>G	c.(958-960)CAA>CGA	p.Q320R	LONRF1_uc010lsp.1_5'UTR	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	320					proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		GATTACCTTTTGTACTTGCAG	0.373													39	64					0	0	0	0	C	12598387	C	C	12598387	3	2	136	1	0	0	0	0	1	0	0	0	8944	1812	63	5	1402	5	LONRF1	8	12598387	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	602551	12598387	133765635	236	24272											
PTK2B	2185	broad.mit.edu	37	chr8	27310644	27310644	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attgcagtggagttcacaggGcccccacagaagcccccgag	10	5	12	14	1	1	1	1	0	0	1	1	3	1	2	4	2	2	2	4	2	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:27310644G>A	uc003xfn.1	+	33	3370	c.2562G>A	c.(2560-2562)GGG>GGA	p.G854G	PTK2B_uc003xfo.1_Silent_p.G854G|PTK2B_uc003xfp.1_Silent_p.G854G|PTK2B_uc003xfq.1_Silent_p.G812G	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	854	Interaction with TGFB1I1 (By similarity).|Pro-rich.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		AGTTCACAGGGCCCCCACAGA	0.542													33	60					0	0	0	0	A	27310644	A	A	27310644	2	1	136	1	0	0	0	0	0	0	0	1	12826	1190	42	4		4	PTK2B	8	27310644	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	14712257	27310644	119053378	237	24273											
FGFR1	2260	broad.mit.edu	37	chr8	38287450	38287450	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaggactccacttccacaggGgctccccagggctgggctgc	7	6	13	15	0	0	0	0	0	0	0	3	1	3	1	4	5	1	3	4	5	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:38287450G>A	uc003xlp.2	-	3	1050	c.108C>T	c.(106-108)GCC>GCT	p.A36A	FGFR1_uc011lbo.1_Silent_p.A36A|FGFR1_uc011lbp.1_Intron|FGFR1_uc011lbq.1_Intron|FGFR1_uc010lwk.2_Silent_p.A28A|FGFR1_uc011lbr.1_5'Flank|FGFR1_uc011lbs.1_Intron|FGFR1_uc011lbt.1_Intron|FGFR1_uc011lbu.1_Silent_p.A69A|FGFR1_uc011lbv.1_Silent_p.A36A|FGFR1_uc011lbw.1_Intron|FGFR1_uc011lbx.1_Intron|FGFR1_uc003xlv.2_Intron|FGFR1_uc003xlu.2_Intron|FGFR1_uc003xlw.1_RNA	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	36	Extracellular (Potential).|Ig-like C2-type 1.				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	CTTCCACAGGGGCTCCCCAGG	0.438		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						82	19					0	0	0	0	A	38287450	A	A	38287450	2	1	136	1	0	0	0	0	0	0	0	1	5895	1219	43	4		4	FGFR1	8	38287450	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	10976806	38287450	108076572	238	24274											
MYST3	7994	broad.mit.edu	37	chr8	41836253	41836253	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccttcttttgtagaagttttCgtccttttttcctaggtcga	5	20	7	9	2	1	1	0	0	1	1	5	2	3	1	3	1	0	2	3	1	3	10			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:41836253C>G	uc010lxb.2	-	7	1494	c.950G>C	c.(949-951)CGA>CCA	p.R317P	MYST3_uc010lxc.2_Missense_Mutation_p.R317P|MYST3_uc003xon.3_Missense_Mutation_p.R317P|MYST3_uc010lxd.2_Missense_Mutation_p.R317P	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	317	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TAGAAGTTTTCGTCCTTTTTT	0.353													33	110					0	0	0	0	G	41836253	G	G	41836253	3	3	136	1	0	0	0	0	1	0	0	0	10157	884	31	3	5112	3	MYST3	8	41836253	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3548803	41836253	104527769	239	24275											
RP1	6101	broad.mit.edu	37	chr8	55533742	55533742	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgctggataacttgtccagGaaggtgcccctcccttttgg	6	12	11	12	0	0	0	0	0	0	0	2	2	2	2	4	4	3	1	4	4	2	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:55533742G>T	uc003xsd.1	+	2	364	c.216G>T	c.(214-216)AGG>AGT	p.R72S	RP1_uc011ldy.1_Missense_Mutation_p.R72S	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	72	Doublecortin 1.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACTTGTCCAGGAAGGTGCCCC	0.592													25	95					9.86323e-18	1.41099e-17	1	0	T	55533742	T	T	55533742	3	4	136	1	0	0	0	0	1	0	0	0	13597	1165	41	2	218	2	RP1	8	55533742	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	13697489	55533742	90830280	240	24276											
PENK	5179	broad.mit.edu	37	chr8	57353977	57353977	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtagtccatccaccactctgGgcgacctactcttctcatga	8	11	7	15	1	3	1	1	1	3	0	6	2	5	1	4	1	1	1	4	1	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:57353977G>C	uc003xsz.2	-	2	739	c.658C>G	c.(658-660)CCA>GCA	p.P220A	PENK_uc003xta.3_Missense_Mutation_p.P220A	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	220					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CACCACTCTGGGCGACCTACT	0.537													47	112					0	0	0	0	C	57353977	C	C	57353977	3	2	136	1	0	0	0	0	1	0	0	0	11781	1232	43	4	149	4	PENK	8	57353977	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1820235	57353977	89010045	241	24277											
CHD7	55636	broad.mit.edu	37	chr8	61774807	61774807	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaccgaaacagaaacgacAtagatgtcgaaaccctaata	20	5	7	9	3	0	2	0	0	0	2	1	6	0	2	2	0	4	0	2	0	7	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:61774807A>G	uc003xue.2	+	36	8360	c.7883A>G	c.(7882-7884)CAT>CGT	p.H2628R		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2628					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CAGAAACGACATAGATGTCGA	0.353													7	11					0	0	0	0	G	61774807	G	G	61774807	3	3	136	1	0	0	0	0	1	0	0	0	3345	217	8	5	8021	5	CHD7	8	61774807	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	4420830	61774807	84589215	242	24278											
SLCO5A1	81796	broad.mit.edu	37	chr8	70594460	70594460	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attaacacagccagccagacAagggttaaagtatgtaattc	16	9	8	8	0	0	1	0	0	0	1	1	1	0	1	2	1	3	3	2	1	6	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:70594460A>C	uc003xyl.2	-	7	2448	c.1741T>G	c.(1741-1743)TGT>GGT	p.C581G	SLCO5A1_uc010lzb.2_Missense_Mutation_p.C526G|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.C581G	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	581	Extracellular (Potential).|Kazal-like.					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCAGCCAGACAAGGGTTAAAG	0.423													17	68					0	0	0	0	C	70594460	C	C	70594460	3	2	136	1	0	0	0	0	1	0	0	0	14795	130	5	5	821	5	SLCO5A1	8	70594460	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	8819653	70594460	75769562	243	24279											
CRISPLD1	83690	broad.mit.edu	37	chr8	75932314	75932314	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctgcttcacattgcccaaGgtaaaccagtgtacacatag	12	9	8	12	0	1	0	1	0	0	0	1	0	1	0	3	1	4	3	3	1	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:75932314G>A	uc003yan.2	+	12	1619	c.1244G>A	c.(1243-1245)AGA>AAA	p.R415K	CRISPLD1_uc011lfk.1_Missense_Mutation_p.R227K|CRISPLD1_uc011lfl.1_Missense_Mutation_p.R227K	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	415	LCCL 2.					extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			CATTGCCCAAGGTAAACCAGT	0.408													14	32					0	0	0	0	A	75932314	A	A	75932314	3	1	136	1	0	0	0	0	1	0	0	0	3897	1014	35	4	1286	4	CRISPLD1	8	75932314	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	5337854	75932314	70431708	244	24280											
CA2	760	broad.mit.edu	37	chr8	86386585	86386585	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cactggaacaccaaatatggGgattttgggaaagctgtgca	13	9	12	7	0	0	0	0	0	0	0	0	3	0	3	1	4	3	2	1	4	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:86386585G>T	uc003ydk.2	+	4	564	c.384G>T	c.(382-384)GGG>GGT	p.G128G		NM_000067	NP_000058	P00918	CAH2_HUMAN	carbonic anhydrase II	128					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(1)	1					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	CCAAATATGGGGATTTTGGGA	0.393													35	111					4.40281e-34	6.83652e-34	1	0	T	86386585	T	T	86386585	2	4	136	1	0	0	0	0	0	0	0	1	2528	1219	43	4		4	CA2	8	86386585	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	10454271	86386585	59977437	245	24281											
TMEM55A	55529	broad.mit.edu	37	chr8	92007999	92007999	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaggagataagcaattgccCaagaaacataggttgctcga	15	8	10	8	1	0	2	0	0	0	2	1	4	0	2	1	2	4	3	1	2	6	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:92007999C>A	uc003yes.2	-	7	906	c.680G>T	c.(679-681)TGG>TTG	p.W227L		NM_018710	NP_061180	Q8N4L2	TM55A_HUMAN	transmembrane protein 55A	227	Helical; (Potential).					integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0			BRCA - Breast invasive adenocarcinoma(11;0.033)			AGCAATTGCCCAAGAAACATA	0.363													15	43					1.67942e-08	2.07576e-08	1	0	A	92007999	A	A	92007999	3	1	136	1	0	0	0	0	1	0	0	0	16247	595	21	4	97	4	TMEM55A	8	92007999	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5621414	92007999	54356023	246	24282											
PKHD1L1	93035	broad.mit.edu	37	chr8	110510777	110510777	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatattgaactcactgctgcTcatcggagtcctagatctcc	10	12	7	12	1	3	2	2	1	1	1	6	3	4	3	2	1	3	2	2	1	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:110510777T>C	uc003yne.2	+	66	10790	c.10686T>C	c.(10684-10686)GCT>GCC	p.A3562A		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3562	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCACTGCTGCTCATCGGAGTC	0.343										HNSCC(38;0.096)			18	47					0	0	0	0	C	110510777	C	C	110510777	2	2	136	1	0	0	0	0	0	0	0	1	12027	1538	54	5		5	PKHD1L1	8	110510777	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	18502778	110510777	35853245	247	24283											
PKHD1L1	93035	broad.mit.edu	37	chr8	110530661	110530661	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agagggaagagtctgaggagGaagagatccatgggattcat	14	7	16	4	0	2	4	1	1	1	3	3	9	3	8	1	4	0	0	1	4	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:110530661G>T	uc003yne.2	+	73	12059	c.11955G>T	c.(11953-11955)AGG>AGT	p.R3985S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3985	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTCTGAGGAGGAAGAGATCCA	0.388										HNSCC(38;0.096)			17	52					1.15088e-07	1.38644e-07	1	0	T	110530661	T	T	110530661	3	4	136	1	0	0	0	0	1	0	0	0	12027	1165	41	2	12245	2	PKHD1L1	8	110530661	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	19884	110530661	35833361	248	24284											
CSMD3	114788	broad.mit.edu	37	chr8	113249531	113249531	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtttccttcctttgaaattGtaagagcctttccatatata	10	18	5	8	0	0	2	0	1	0	1	3	2	3	2	4	0	1	2	4	0	5	9			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:113249531G>C	uc003ynu.2	-	67	10674	c.10515C>G	c.(10513-10515)TAC>TAG	p.Y3505*	CSMD3_uc003yns.2_Nonsense_Mutation_p.Y2707*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.Y3465*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.Y3336*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3505	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTTGAAATTGTAAGAGCCTT	0.348										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	50					0	0	0	0	C	113249531	C	C	113249531	4	2	136	1	0	0	0	0	0	1	0	0	3963	1372	48	4	628	4	CSMD3	8	113249531	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2718870	113249531	33114491	249	24285											
CSMD3	114788	broad.mit.edu	37	chr8	113277722	113277722	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattcaattccatcgtgtaGcctggctggcacatgtaaga	10	11	9	11	1	1	1	1	0	0	1	3	1	2	1	3	2	1	4	3	2	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:113277722G>T	uc003ynu.2	-	60	9765	c.9606C>A	c.(9604-9606)GGC>GGA	p.G3202G	CSMD3_uc003yns.2_Silent_p.G2404G|CSMD3_uc003ynt.2_Silent_p.G3162G|CSMD3_uc011lhx.1_Silent_p.G3033G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3202	Extracellular (Potential).|Sushi 24.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCATCGTGTAGCCTGGCTGGC	0.423										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			32	63					2.08457e-15	2.88848e-15	1	0	T	113277722	T	T	113277722	2	4	136	1	0	0	0	0	0	0	0	1	3963	958	34	4		4	CSMD3	8	113277722	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	28191	113277722	33086300	250	24286											
CSMD3	114788	broad.mit.edu	37	chr8	113317077	113317077	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttggttttgtattcataatgGgagccattcacaattcgcca	10	15	8	8	1	2	0	2	0	0	0	3	1	2	1	2	2	1	2	2	2	3	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:113317077G>A	uc003ynu.2	-	52	8298	c.8139C>T	c.(8137-8139)TCC>TCT	p.S2713S	CSMD3_uc003yns.2_Silent_p.S1915S|CSMD3_uc003ynt.2_Silent_p.S2673S|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2713	Extracellular (Potential).|Sushi 16.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATTCATAATGGGAGCCATTCA	0.403										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	25					0	0	0	0	A	113317077	A	A	113317077	2	1	136	1	0	0	0	0	0	0	0	1	3963	1219	43	4		4	CSMD3	8	113317077	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	39355	113317077	33046945	251	24287											
OC90	729330	broad.mit.edu	37	chr8	133036754	133036754	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccatgaagaggcccgatccCcaagggacccagtgacttcc	10	6	10	15	1	0	3	0	2	0	1	3	5	3	4	6	2	0	0	6	2	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:133036754C>A	uc003ytg.2	-	13	1408	c.1408G>T	c.(1408-1410)GGG>TGG	p.G470W	OC90_uc011lix.1_Missense_Mutation_p.G470W	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	486					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GGCCCGATCCCCAAGGGACCC	0.582													13	25					3.27435e-08	4.00703e-08	1	0	A	133036754	A	A	133036754	3	1	136	1	0	0	0	0	1	0	0	0	10868	623	22	4	29	4	OC90	8	133036754	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	19719677	133036754	13327268	252	24288											
PHF20L1	51105	broad.mit.edu	37	chr8	133856460	133856460	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaagggcaccgaagacccAggagactcacatcttcagtg	15	5	10	11	1	3	2	2	0	1	2	3	4	3	2	2	2	0	1	2	2	3	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:133856460A>G	uc003ytt.2	+	20	3133	c.2808A>G	c.(2806-2808)CCA>CCG	p.P936P	PHF20L1_uc011lja.1_Silent_p.P910P	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	936							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			CCGAAGACCCAGGAGACTCAC	0.418													25	47					0	0	0	0	G	133856460	G	G	133856460	2	3	136	1	0	0	0	0	0	0	0	1	11887	175	7	5		5	PHF20L1	8	133856460	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	819706	133856460	12507562	253	24289											
ZFAT	57623	broad.mit.edu	37	chr8	135614050	135614050	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atctgacccagcactctgggCcttggacagcagtagtgtga	9	9	12	11	0	2	2	0	2	2	0	2	3	2	3	2	2	2	3	2	2	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:135614050C>A	uc003yup.2	-	6	2087	c.1912G>T	c.(1912-1914)GCC>TCC	p.A638S	ZFAT_uc003yun.2_Missense_Mutation_p.A626S|ZFAT_uc003yuo.2_Missense_Mutation_p.A626S|ZFAT_uc010meh.2_Missense_Mutation_p.A626S|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.A626S|ZFAT_uc010mej.2_Missense_Mutation_p.A576S|ZFAT_uc003yur.2_Missense_Mutation_p.A626S	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	638					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GCACTCTGGGCCTTGGACAGC	0.597													21	76					3.5997e-14	4.91085e-14	1	0	A	135614050	A	A	135614050	3	1	136	1	0	0	0	0	1	0	0	0	17699	739	26	4	1863	4	ZFAT	8	135614050	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1757590	135614050	10749972	254	24290											
MAPK15	225689	broad.mit.edu	37	chr8	144804268	144804272	+	Frame_Shift_Del	DEL	GGCCC	-	-																															cctccccggcttcctccggaGgcccggcccggccggaggat																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr8:144804268_144804272delGGCCC	uc003yzj.2	+	14	1523_1527	c.1482_1486delGGCCC	c.(1480-1488)GAGGCCCGGfs	p.E494fs		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	494_496					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TTCCTCCGGAGGCCCGGCCCGGCCG	0.659													---	---	---								-	144804272	-	-	144804268	7	5	136	1	0	1	0	1	0	0	0	0	9330	991	35	0	1536	0	MAPK15	8	144804268	Frame_Shift_Del	DEL	GGCCC	TCGA-CR-7364-01A-11D-2012-08	9190218	144804268	1559754	255	24291											
KANK1	23189	broad.mit.edu	37	chr9	738306	738306	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttctgtctgaacaccctcCagcacgagtggttccgcgtg	6	10	12	13	3	2	1	0	1	2	0	4	2	4	1	3	2	2	3	3	2	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr9:738306C>T	uc003zgl.1	+	12	4004	c.3355C>T	c.(3355-3357)CAG>TAG	p.Q1119*	KANK1_uc003zgn.1_Nonsense_Mutation_p.Q1119*|KANK1_uc003zgs.1_Nonsense_Mutation_p.Q961*|KANK1_uc010mgx.1_Nonsense_Mutation_p.Q97*|KANK1_uc010mgy.1_Nonsense_Mutation_p.Q31*|KANK1_uc003zgt.1_Nonsense_Mutation_p.Q31*	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	1119					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GAACACCCTCCAGCACGAGTG	0.502													8	12					0	0	0	0	T	738306	T	T	738306	4	4	136	1	0	0	0	0	0	1	0	0	8015	595	21	4	3381	4	KANK1	9	738306	Nonsense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08		738306	140475125	256	24292											
PTPRD	5789	broad.mit.edu	37	chr9	8340364	8340364	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcccatttcacgcagcttGgtgagcatcacaactatggt	9	11	9	12	1	2	1	2	1	0	0	2	1	2	1	1	2	4	3	1	2	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr9:8340364G>T	uc003zkk.2	-	41	5943	c.5232C>A	c.(5230-5232)ACC>ACA	p.T1744T	PTPRD_uc003zkp.2_Silent_p.T1338T|PTPRD_uc003zkq.2_Silent_p.T1337T|PTPRD_uc003zkr.2_Silent_p.T1328T|PTPRD_uc003zks.2_Silent_p.T1337T|PTPRD_uc003zkl.2_Silent_p.T1735T|PTPRD_uc003zkm.2_Silent_p.T1731T|PTPRD_uc003zkn.2_Silent_p.T1333T|PTPRD_uc003zko.2_Silent_p.T1334T	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1744	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CACGCAGCTTGGTGAGCATCA	0.483										TSP Lung(15;0.13)			18	26					9.16793e-09	1.13771e-08	1	0	T	8340364	T	T	8340364	2	4	136	1	0	0	0	0	0	0	0	1	12864	1335	47	4		4	PTPRD	9	8340364	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	7602058	8340364	132873067	257	24293											
ALDH1B1	219	broad.mit.edu	37	chr9	38395768	38395768	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgcgcttcctggcaccccGgctgcttagcctccagggca	4	8	12	17	2	0	0	0	0	0	0	2	0	2	0	5	3	3	6	5	3	1	2	rs61757680		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr9:38395768G>A	uc004aay.2	+	2	135	c.23G>A	c.(22-24)CGG>CAG	p.R8Q		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	8					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	CTGGCACCCCGGCTGCTTAGC	0.627													30	44					0	0	0	0	A	38395768	A	A	38395768	3	1	136	1	0	0	0	0	1	0	0	0	493	1116	39	1	25	1	ALDH1B1	9	38395768	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	30055404	38395768	102817663	258	24294											
SMC5	23137	broad.mit.edu	37	chr9	72897368	72897368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgttcgtcaggaatatgaaGaagtaaaactagttcgtgac	15	11	10	5	2	1	3	1	2	0	1	3	4	1	4	0	1	1	3	0	1	7	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr9:72897368G>A	uc004ahr.2	+	7	967	c.850G>A	c.(850-852)GAA>AAA	p.E284K		NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	284	Potential.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						GGAATATGAAGAAGTAAAACT	0.353													16	29					0	0	0	0	A	72897368	A	A	72897368	3	1	136	1	0	0	0	0	1	0	0	0	14850	943	33	2	876	2	SMC5	9	72897368	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	34501600	72897368	68316063	259	24295											
FLJ46321	389763	broad.mit.edu	37	chr9	84607177	84607177	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tactacctagtcctctattcCtgattaggatctgtggagtg	8	15	9	9	0	2	1	0	1	2	0	4	3	4	3	3	2	2	0	3	2	5	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr9:84607177C>T	uc004amn.2	+	4	1839	c.1792C>T	c.(1792-1794)CTG>TTG	p.L598L		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	598						integral to membrane					0						TCCTCTATTCCTGATTAGGAT	0.502													28	50					0	0	0	0	T	84607177	T	T	84607177	2	4	136	1	0	0	0	0	0	0	0	1	5964	680	24	4		4	FLJ46321	9	84607177	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	11709809	84607177	56606254	260	24296											
FGD3	89846	broad.mit.edu	37	chr9	95738930	95738930	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggaggcggacagcgacgtggGtgaggaacctgactctgaga	10	5	18	8	3	1	3	0	3	1	1	1	8	1	6	1	5	2	0	1	5	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr9:95738930G>T	uc004asw.2	+	3	1020	c.392G>T	c.(391-393)GGT>GTT	p.G131V	FGD3_uc004asx.2_Missense_Mutation_p.G131V|FGD3_uc004asz.2_Missense_Mutation_p.G131V	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	131					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						AGCGACGTGGGTGAGGAACCT	0.682													23	30					9.04412e-07	1.06058e-06	1	0	T	95738930	T	T	95738930	3	4	136	1	0	0	0	0	1	0	0	0	5866	1261	44	4	394	4	FGD3	9	95738930	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	11131753	95738930	45474501	261	24297											
KIAA1529	57653	broad.mit.edu	37	chr9	100092789	100092789	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taactgaagaggtgctggggCagcagaaaaaatctccactg	14	7	12	8	0	1	3	0	1	1	2	2	3	1	3	1	3	3	3	1	3	5	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr9:100092789C>T	uc011lut.1	+	30	3336	c.2563C>T	c.(2563-2565)CAG>TAG	p.Q855*	KIAA1529_uc004axe.1_Nonsense_Mutation_p.Q855*|KIAA1529_uc004axg.1_Nonsense_Mutation_p.Q716*|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Nonsense_Mutation_p.Q40*|KIAA1529_uc011lus.1_Nonsense_Mutation_p.Q673*|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Nonsense_Mutation_p.Q716*|KIAA1529_uc011luv.1_Nonsense_Mutation_p.Q713*	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				GGTGCTGGGGCAGCAGAAAAA	0.453													10	25					0	0	0	0	T	100092789	T	T	100092789	4	4	136	1	0	0	0	0	0	1	0	0	8279	711	25	4	2645	4	KIAA1529	9	100092789	Nonsense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	4353859	100092789	41120642	262	24298											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123170649	123170649	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagtctcctgtgctcttcatCcagcttctcatacgccttca	6	14	5	16	1	5	0	3	0	3	0	8	0	6	0	3	0	3	2	3	0	1	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr9:123170649C>G	uc004bkf.2	-	31	4883	c.4702G>C	c.(4702-4704)GAT>CAT	p.D1568H	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.D577H|CDK5RAP2_uc004bke.2_Missense_Mutation_p.D853H|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.D1568H|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.D833H|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.D833H|CDK5RAP2_uc011lya.1_Missense_Mutation_p.D833H|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.D1338H|CDK5RAP2_uc004bki.2_Missense_Mutation_p.D1335H	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1568					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						TGCTCTTCATCCAGCTTCTCA	0.557													24	51					0	0	0	0	G	123170649	G	G	123170649	3	3	136	1	0	0	0	0	1	0	0	0	3161	855	30	2	1011	2	CDK5RAP2	9	123170649	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	23077860	123170649	18042782	263	24299											
NR5A1	2516	broad.mit.edu	37	chr9	127253385	127253385	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaagaggatgatgaacttGaggcagacaaactcctgccg	13	7	12	9	1	0	6	0	4	0	2	1	7	1	7	2	2	3	1	2	2	3	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr9:127253385G>C	uc004boo.1	-	6	1300	c.1113C>G	c.(1111-1113)CTC>CTG	p.L371L		NM_004959	NP_004950	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	371	Important for dimerization.				cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						TGATGAACTTGAGGCAGACAA	0.652													7	12					0	0	0	0	C	127253385	C	C	127253385	2	2	136	1	0	0	0	0	0	0	0	1	10689	1277	45	2		2	NR5A1	9	127253385	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4082736	127253385	13960046	264	24300											
GAPVD1	26130	broad.mit.edu	37	chr9	128099315	128099315	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgcccaccagctgacctCtcctccttctcagtcagagt	7	10	8	16	0	3	2	2	1	2	1	6	2	4	2	5	1	2	1	5	1	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr9:128099315C>T	uc010mwx.2	+	16	2773	c.2447C>T	c.(2446-2448)TCT>TTT	p.S816F	GAPVD1_uc011lzs.1_Missense_Mutation_p.S816F|GAPVD1_uc004bpp.2_Missense_Mutation_p.S843F|GAPVD1_uc004bpq.2_Missense_Mutation_p.S816F|GAPVD1_uc004bpr.2_Missense_Mutation_p.S795F|GAPVD1_uc004bps.2_Missense_Mutation_p.S816F|GAPVD1_uc010mwy.1_Intron	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	816					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CAGCTGACCTCTCCTCCTTCT	0.468													22	31					0	0	0	0	T	128099315	T	T	128099315	3	4	136	1	0	0	0	0	1	0	0	0	6274	913	32	2	2582	2	GAPVD1	9	128099315	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	845930	128099315	13114116	265	24301											
OLAH	55301	broad.mit.edu	37	chr10	15113820	15113820	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtaccatctaaggctgttcTttcctgtgacttgacatgtt	7	16	8	10	1	2	2	0	2	2	0	3	2	3	2	2	1	1	4	2	1	2	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:15113820T>A	uc001inu.2	+	7	853	c.599T>A	c.(598-600)CTT>CAT	p.L200H	ACBD7_uc010qby.1_Intron|OLAH_uc001int.2_Missense_Mutation_p.L253H	NM_001039702	NP_001034791	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase isoform 2	200					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity				0						AAGGCTGTTCTTTCCTGTGAC	0.343													21	67					0	0	0	0	A	15113820	A	A	15113820	3	1	136	1	0	0	0	0	1	0	0	0	10905	1609	56	5	784	5	OLAH	10	15113820	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08		15113820	120420927	266	24302											
CUBN	8029	broad.mit.edu	37	chr10	17127685	17127685	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcaaaggggccagtagtcTggagcggtgggacagagaaa	12	5	18	6	1	1	1	0	0	1	1	1	4	1	3	1	6	1	2	1	6	3	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:17127685T>A	uc001ioo.2	-	16	2073	c.2021A>T	c.(2020-2022)CAG>CTG	p.Q674L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	674	CUB 2.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCCAGTAGTCTGGAGCGGTGG	0.458													26	84					0	0	0	0	A	17127685	A	A	17127685	3	1	136	1	0	0	0	0	1	0	0	0	4068	1580	55	5	9058	5	CUBN	10	17127685	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	2013865	17127685	118407062	267	24303											
PTCHD3	374308	broad.mit.edu	37	chr10	27687958	27687958	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttataaaaatagcaaaataaCagggtcattcctgtatagat	18	12	6	5	0	1	1	1	0	0	1	2	1	2	1	1	1	2	2	1	1	10	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:27687958C>A	uc001itu.2	-	4	1687	c.1569G>T	c.(1567-1569)CTG>CTT	p.L523L		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	523	SSD.|Helical; (Potential).				spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						AGCAAAATAACAGGGTCATTC	0.388													18	69					0.000958276	0.00105189	1	0	A	27687958	A	A	27687958	2	1	136	1	0	0	0	0	0	0	0	1	12796	465	17	4		4	PTCHD3	10	27687958	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	10560273	27687958	107846789	268	24304											
PTCHD3	374308	broad.mit.edu	37	chr10	27702471	27702471	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgcgccacgcgcagatcctGcaccgcgccgtccagtttgc	5	6	11	19	7	0	1	0	0	0	1	2	1	2	1	6	0	2	3	6	0	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:27702471G>A	uc001itu.2	-	1	827	c.709C>T	c.(709-711)CAG>TAG	p.Q237*		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	237					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CGCAGATCCTGCACCGCGCCG	0.617													6	53					0	0	0	0	A	27702471	A	A	27702471	4	1	136	1	0	0	0	0	0	1	0	0	12796	1328	46	4	1610	4	PTCHD3	10	27702471	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	14513	27702471	107832276	269	24305											
RBP3	5949	broad.mit.edu	37	chr10	48389293	48389293	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acgttgggtgctgtagcgtgGgcccgggagctccatgtggc	4	9	18	10	3	0	0	0	0	0	0	1	1	1	1	2	4	3	4	2	4	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:48389293G>C	uc001jez.2	-	1	1699	c.1585C>G	c.(1585-1587)CCA>GCA	p.P529A		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	529	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CTGTAGCGTGGGCCCGGGAGC	0.667													13	67					0	0	0	0	C	48389293	C	C	48389293	3	2	136	1	0	0	0	0	1	0	0	0	13222	1232	43	4	2174	4	RBP3	10	48389293	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	20686822	48389293	87145454	270	24306											
C10orf72	196740	broad.mit.edu	37	chr10	50315862	50315863	+	Missense_Mutation	DNP	CA	AT	AT																															tgcaccacccggagcttggtCatcttcaccatcaaggcctc																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:50315862_50315863CA>AT	uc001jhf.2	-	2	262_263	c.233_234TG>AT	c.(232-234)ATG>AAT	p.M78N	C10orf72_uc001jhh.2_Missense_Mutation_p.M78N	NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	78	Ig-like.|Extracellular (Potential).					integral to membrane|plasma membrane					0						GGAGCTTGGTCATCTTCACCAT	0.629													7	48					0	0	0	0	AT	50315863	AT	AT	50315862	3	1	136	1	0	0	0	0	1	0	0	0	1621	826	29	2	879	2	C10orf72	10	50315862	Missense_Mutation	DNP	CA	TCGA-CR-7364-01A-11D-2012-08	1926569	50315862	85218885	271	24307											
CHAT	1103	broad.mit.edu	37	chr10	50870701	50870701	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aactacacaggccataacagGgatggccattgacaaccacc	15	5	8	13	0	0	1	0	1	0	0	0	2	0	2	4	3	4	0	4	3	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:50870701G>A	uc001jhz.2	+	14	2003	c.1850G>A	c.(1849-1851)GGG>GAG	p.G617E	CHAT_uc001jhv.1_Missense_Mutation_p.G499E|CHAT_uc001jhx.1_Missense_Mutation_p.G499E|CHAT_uc001jhy.1_Missense_Mutation_p.G499E|CHAT_uc001jia.2_Missense_Mutation_p.G499E|CHAT_uc010qgs.1_Missense_Mutation_p.G499E	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	617					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GCCATAACAGGGATGGCCATT	0.572													36	84					0	0	0	0	A	50870701	A	A	50870701	3	1	136	1	0	0	0	0	1	0	0	0	3328	1232	43	4	1948	4	CHAT	10	50870701	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	554839	50870701	84664046	272	24308											
C10orf53	282966	broad.mit.edu	37	chr10	50916545	50916545	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaggacctgacttgtactgTattggcccagattggatcat	9	12	10	10	0	1	2	1	1	0	1	1	4	1	4	3	3	1	2	3	3	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:50916545T>A	uc001jid.1	+	3	416	c.356T>A	c.(355-357)GTA>GAA	p.V119E		NM_182554	NP_872360	Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53 isoform a	Error:Variant_position_missing_in_Q8N6V4_after_alignment											0		all_neural(218;0.107)				acttgtactgtattggcccag	0													61	165					0	0	0	0	A	50916545	A	A	50916545	3	1	136	1	0	0	0	0	1	0	0	0	1612	1638	57	5	435	5	C10orf53	10	50916545	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	45844	50916545	84618202	273	24309											
OGDHL	55753	broad.mit.edu	37	chr10	50964873	50964873	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtggtcctccaccaatttGctggtcttggtccgacttga	6	13	11	11	1	1	1	0	1	1	0	4	2	4	1	4	4	1	1	4	4	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:50964873G>T	uc001jie.2	-	3	466	c.324C>A	c.(322-324)AGC>AGA	p.S108R	OGDHL_uc009xog.2_Missense_Mutation_p.S135R|OGDHL_uc010qgt.1_Intron|OGDHL_uc010qgu.1_Intron|OGDHL_uc009xoh.2_5'UTR	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	108					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						CCACCAATTTGCTGGTCTTGG	0.632													28	46					3.65163e-15	5.04856e-15	1	0	T	50964873	T	T	50964873	3	4	136	1	0	0	0	0	1	0	0	0	10894	1310	46	4	2792	4	OGDHL	10	50964873	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	48328	50964873	84569874	274	24310											
AGAP6	414189	broad.mit.edu	37	chr10	51768720	51768720	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgctgacaccatcgggagcGgtagagccatccccattaaa	12	7	10	12	2	0	2	0	1	0	1	2	3	1	3	4	2	3	2	4	2	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:51768720G>A	uc001jix.3	+	8	1233	c.835G>A	c.(835-837)GGT>AGT	p.G279S		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	279					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						CATCGGGAGCGGTAGAGCCAT	0.512													71	339					0	0	0	0	A	51768720	A	A	51768720	3	1	136	1	0	0	0	0	1	0	0	0	372	1116	39	1	865	1	AGAP6	10	51768720	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	803847	51768720	83766027	275	24311											
SUPV3L1	6832	broad.mit.edu	37	chr10	70962202	70962202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttttactaaaaggcagctgGtcttcatccaactgctgagc	10	12	8	11	0	2	1	1	1	1	0	3	1	3	1	1	2	5	3	1	2	4	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:70962202G>A	uc001jpe.1	+	12	1581	c.1526G>A	c.(1525-1527)GGT>GAT	p.G509D	SUPV3L1_uc010qjd.1_Missense_Mutation_p.G378D	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	509	Helicase C-terminal.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						AAGGCAGCTGGTCTTCATCCA	0.363													31	59					0	0	0	0	A	70962202	A	A	70962202	3	1	136	1	0	0	0	0	1	0	0	0	15468	1261	44	4	1572	4	SUPV3L1	10	70962202	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	19193482	70962202	64572545	276	24312											
SFTPA1	653509	broad.mit.edu	37	chr10	81372067	81372067	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccatgtctcttttctctgcaGgccccatgggtccacctgga	5	12	9	15	0	2	0	0	0	2	0	5	1	3	1	5	3	1	1	5	3	0	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:81372067G>T	uc001kap.2	+	4	294	c.173_splice	c.e4-1	p.G58_splice	SFTPA1_uc001kaq.2_Splice_Site_p.G58_splice|SFTPA1_uc009xry.2_Splice_Site_p.G73_splice|SFTPA1_uc001kar.2_Splice_Site_p.G58_splice|SFTPA1_uc010qlt.1_Splice_Site|SFTPA1_uc009xrz.2_Intron|SFTPA1_uc009xsa.2_Splice_Site_p.G58_splice|SFTPA1_uc009xsf.2_5'Flank	NM_005411	NP_005402	Q8IWL2	SFTA1_HUMAN	surfactant protein A1 isoform 1						cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TTTCTCTGCAGGCCCCATGGG	0.567													100	264					7.59261e-44	1.19092e-43	1	0	T	81372067	T	T	81372067	5	4	136	1	0	0	0	0	0	0	1	0	14254	1014	35	4	227	4	SFTPA1	10	81372067	Splice_Site	SNP	G	TCGA-CR-7364-01A-11D-2012-08	10409865	81372067	54162680	277	24313											
MINPP1	9562	broad.mit.edu	37	chr10	89264702	89264702	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcgcccggctgcctcctccgGacctccgtagcgcctgccgc	2	6	12	21	6	0	0	0	0	0	0	3	1	3	1	8	2	3	2	8	2	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:89264702G>T	uc001keu.2	+	1	480	c.30G>T	c.(28-30)CGG>CGT	p.R10R	MINPP1_uc009xtf.1_RNA|MINPP1_uc001kev.2_Silent_p.R10R	NM_004897	NP_004888	Q9UNW1	MINP1_HUMAN	multiple inositol polyphosphate histidine	10					bone mineralization|polyphosphate metabolic process	endoplasmic reticulum lumen	acid phosphatase activity|bisphosphoglycerate 3-phosphatase activity|multiple inositol-polyphosphate phosphatase activity|phosphohistidine phosphatase activity			urinary_tract(1)	1		Colorectal(252;0.122)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00123)		GCCTCCTCCGGACCTCCGTAG	0.731													6	23					0.00116845	0.00128032	1	0	T	89264702	T	T	89264702	2	4	136	1	0	0	0	0	0	0	0	1	9641	1161	41	2		2	MINPP1	10	89264702	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	7892635	89264702	46270045	278	24314											
FAS	355	broad.mit.edu	37	chr10	90768682	90768682	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaactgcacccggacccagaAtaccaagtgcagatgtaaac	16	5	8	12	1	0	2	0	0	0	2	0	3	0	3	3	1	5	3	3	1	6	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:90768682A>G	uc001kfr.2	+	4	717	c.371A>G	c.(370-372)AAT>AGT	p.N124S	FAS_uc010qna.1_RNA|FAS_uc001kfs.2_Missense_Mutation_p.N124S|FAS_uc001kft.2_Missense_Mutation_p.N124S|FAS_uc010qnb.1_Intron|FAS_uc010qnc.1_Intron|FAS_uc001kfw.2_Intron|FAS_uc010qnd.1_Intron|FAS_uc010qne.1_Intron|FAS_uc009xtp.2_RNA	NM_000043	NP_000034	P25445	TNR6_HUMAN	tumor necrosis factor receptor superfamily,	124	Extracellular (Potential).|TNFR-Cys 2.				activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			upper_aerodigestive_tract(1)|breast(1)	2		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		CGGACCCAGAATACCAAGTGC	0.363									Autoimmune_Lymphoproliferative_syndrome_type_I				136	359					0	0	0	0	G	90768682	G	G	90768682	3	3	136	1	0	0	0	0	1	0	0	0	5713	101	4	5	385	5	FAS	10	90768682	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	1503980	90768682	44766065	279	24315											
LOXL4	84171	broad.mit.edu	37	chr10	100012126	100012126	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atacctgtggggcagtttgtGtcctccagacagaagctggc	8	10	13	10	0	0	2	0	0	0	2	2	2	2	2	3	3	2	3	3	3	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:100012126G>A	uc001kpa.1	-	12	2086	c.1935C>T	c.(1933-1935)GAC>GAT	p.D645D		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	645	Lysyl-oxidase like.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		GGCAGTTTGTGTCCTCCAGAC	0.537													47	111					0	0	0	0	A	100012126	A	A	100012126	2	1	136	1	0	0	0	0	0	0	0	1	8952	1368	48	4		4	LOXL4	10	100012126	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	9243444	100012126	35522621	280	24316											
FAM178A	55719	broad.mit.edu	37	chr10	102684054	102684054	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atccaagtggcaggtaccaaGgagactaagatgcagaaacc	16	5	11	9	0	0	3	0	0	0	3	1	4	1	3	3	3	3	3	3	3	5	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:102684054G>A	uc001krt.3	+	5	1838	c.1296G>A	c.(1294-1296)AAG>AAA	p.K432K	FAM178A_uc001krr.1_Silent_p.K432K|FAM178A_uc001krs.2_Silent_p.K432K|FAM178A_uc001kru.1_Silent_p.K367K	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	432											0						CAGGTACCAAGGAGACTAAGA	0.443													50	139					0	0	0	0	A	102684054	A	A	102684054	2	1	136	1	0	0	0	0	0	0	0	1	5531	991	35	4		4	FAM178A	10	102684054	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2671928	102684054	32850693	281	24317											
C10orf79	80217	broad.mit.edu	37	chr10	105948147	105948147	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagagacactgtggatatcTgtaaaatgtctttggccacc	13	11	9	8	0	2	1	0	0	2	1	2	3	2	2	2	2	0	1	2	2	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:105948147T>C	uc001kxw.2	-	13	1684	c.1568A>G	c.(1567-1569)CAG>CGG	p.Q523R	C10orf79_uc009xxq.2_5'Flank|C10orf79_uc001kxx.3_Missense_Mutation_p.Q524R	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	523											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TGTGGATATCTGTAAAATGTC	0.408													19	44					0	0	0	0	C	105948147	C	C	105948147	3	2	136	1	0	0	0	0	1	0	0	0	1624	1580	55	5	3533	5	C10orf79	10	105948147	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	3264093	105948147	29586600	282	24318											
NRAP	4892	broad.mit.edu	37	chr10	115381802	115381802	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcattgggatttggtgtcCtcgaatcccttcttgtactc	5	16	10	10	1	1	0	0	0	1	0	5	2	3	1	2	3	1	2	2	3	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:115381802C>A	uc001laj.2	-	24	2759	c.2595G>T	c.(2593-2595)GAG>GAT	p.E865D	NRAP_uc009xyb.2_Intron|NRAP_uc001lak.2_Missense_Mutation_p.E830D|NRAP_uc001lal.3_Missense_Mutation_p.E865D	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	865	Nebulin 21.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		ATTTGGTGTCCTCGAATCCCT	0.532													35	66					4.62619e-21	6.80711e-21	1	0	A	115381802	A	A	115381802	3	1	136	1	0	0	0	0	1	0	0	0	10692	680	24	4	2673	4	NRAP	10	115381802	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	9433655	115381802	20152945	283	24319											
ATRNL1	26033	broad.mit.edu	37	chr10	116975564	116975564	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccatttatgttcatggaggGtataaagcattgccagggaa	12	12	11	6	0	1	0	1	0	0	0	2	2	2	2	2	3	2	3	2	3	5	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:116975564G>A	uc001lcg.2	+	9	1844	c.1458G>A	c.(1456-1458)GGG>GGA	p.G486G		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	486	Kelch 4.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TTCATGGAGGGTATAAAGCAT	0.353													10	24					0	0	0	0	A	116975564	A	A	116975564	2	1	136	1	0	0	0	0	0	0	0	1	1209	1248	44	4		4	ATRNL1	10	116975564	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1593762	116975564	18559183	284	24320											
FAM24A	118670	broad.mit.edu	37	chr10	124672281	124672281	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgtcttttcttaagagcTgcaaaggaccctgatgctgt	8	14	11	8	0	2	2	0	1	2	1	2	3	2	3	1	1	3	3	1	1	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:124672281T>A	uc001lgv.2	+	3	250	c.129T>A	c.(127-129)GCT>GCA	p.A43A		NM_001029888	NP_001025059	A6NFZ4	FA24A_HUMAN	family with sequence similarity 24, member A	43						extracellular region				ovary(2)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.124)|COAD - Colon adenocarcinoma(40;0.141)		TCTTAAGAGCTGCAAAGGACC	0.473													29	66					0	0	0	0	A	124672281	A	A	124672281	2	1	136	1	0	0	0	0	0	0	0	1	5576	1567	55	5		5	FAM24A	10	124672281	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	7696717	124672281	10862466	285	24321											
C10orf137	26098	broad.mit.edu	37	chr10	127411642	127411642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttttctctttggtagctttgGcatggcatatgactttattg	6	20	9	6	0	1	1	0	1	1	0	2	1	1	1	0	3	1	4	0	3	3	9			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:127411642G>A	uc001liq.1	+	3	616	c.323G>A	c.(322-324)GGC>GAC	p.G108D	C10orf137_uc001lin.2_Missense_Mutation_p.G108D|C10orf137_uc001lio.1_Missense_Mutation_p.G108D|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GGTAGCTTTGGCATGGCATAT	0.328													36	130					0	0	0	0	A	127411642	A	A	127411642	3	1	136	1	0	0	0	0	1	0	0	0	1600	1203	42	4	333	4	C10orf137	10	127411642	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2739361	127411642	8123105	286	24322											
TCERG1L	256536	broad.mit.edu	37	chr10	132965138	132965138	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggccactcggccccgctcTgtccttgtatctgttgggcc	2	11	12	16	3	2	0	0	0	2	0	4	0	3	0	5	3	0	3	5	3	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:132965138T>C	uc001lkp.2	-	5	953	c.867A>G	c.(865-867)ACA>ACG	p.T289T	TCERG1L_uc009yax.1_RNA	NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	289										large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		GGCCCCGCTCTGTCCTTGTAT	0.527													7	32					0	0	0	0	C	132965138	C	C	132965138	2	2	136	1	0	0	0	0	0	0	0	1	15752	1567	55	5		5	TCERG1L	10	132965138	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	5553496	132965138	2569609	287	24323											
KNDC1	85442	broad.mit.edu	37	chr10	135012588	135012588	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggggaacgtgatgaccagaGtccagacagtgtcccagaga	12	5	14	10	2	0	5	0	2	0	3	2	7	2	6	3	2	1	0	3	2	1	0	rs113826287		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:135012588G>T	uc001llz.1	+	14	2577	c.2576G>T	c.(2575-2577)AGT>ATT	p.S859I	KNDC1_uc001lma.1_Missense_Mutation_p.S794I|KNDC1_uc001lmb.1_Missense_Mutation_p.S271I	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	859	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GATGACCAGAGTCCAGACAGT	0.736													11	18					4.68919e-08	5.72711e-08	1	0	T	135012588	T	T	135012588	3	4	136	1	0	0	0	0	1	0	0	0	8465	1029	36	4	2630	4	KNDC1	10	135012588	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2047450	135012588	522159	288	24324											
KNDC1	85442	broad.mit.edu	37	chr10	135024220	135024220	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcgaccgcatcaacagcacGctgaccaggtaccaagctcc	11	5	8	17	3	1	1	1	1	0	0	3	2	2	1	4	1	4	5	4	1	3	1	rs144385432		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr10:135024220G>T	uc001llz.1	+	21	3901	c.3900G>T	c.(3898-3900)ACG>ACT	p.T1300T		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1300	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TCAACAGCACGCTGACCAGGT	0.612													36	112					9.8876e-21	1.44116e-20	1	0	T	135024220	T	T	135024220	2	4	136	1	0	0	0	0	0	0	0	1	8465	1074	38	3		3	KNDC1	10	135024220	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	11632	135024220	510527	289	24325											
OR51A2	401667	broad.mit.edu	37	chr11	4976784	4976784	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcccatgcaaggagggctCtgtcttgatgataaaaagaa	13	8	13	7	0	2	3	0	2	2	1	2	4	2	4	1	3	1	2	1	3	5	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:4976784C>A	uc010qyt.1	-	1	160	c.160G>T	c.(160-162)GAG>TAG	p.E54*		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGGAGGGCTCTGTCTTGATG	0.428													20	22					2.89027e-11	3.76832e-11	1	0	A	4976784	A	A	4976784	4	1	136	1	0	0	0	0	0	1	0	0	11140	922	32	2	783	2	OR51A2	11	4976784	Nonsense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08		4976784	130029732	290	24326											
OR52A1	23538	broad.mit.edu	37	chr11	5173083	5173083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgggagatgactgttgtgtGataaaattgaaaccggcact	12	11	13	5	1	0	4	0	3	0	1	0	5	0	4	1	2	1	2	1	2	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:5173083G>A	uc010qyy.1	-	1	517	c.517C>T	c.(517-519)CAC>TAC	p.H173Y		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	173	Extracellular (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTGTTGTGTGATAAAATTGA	0.443													31	55					0	0	0	0	A	5173083	A	A	5173083	3	1	136	1	0	0	0	0	1	0	0	0	11162	1290	45	2	423	2	OR52A1	11	5173083	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	196299	5173083	129833433	291	24327											
OR51B5	282763	broad.mit.edu	37	chr11	5364443	5364443	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagactcgagaaaggaaagTgagtgtataaagtaggcctg	15	7	13	6	1	0	3	0	1	0	2	1	5	0	4	2	2	0	2	2	2	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:5364443T>A	uc001map.1	-	1	312	c.312A>T	c.(310-312)TCA>TCT	p.S104S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Silent_p.S104S	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAAGGAAAGTGAGTGTATAA	0.507													14	49					0	0	0	0	A	5364443	A	A	5364443	2	1	136	1	0	0	0	0	0	0	0	1	11145	1683	59	5		5	OR51B5	11	5364443	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	191360	5364443	129642073	292	24328											
OR51I2	390064	broad.mit.edu	37	chr11	5474910	5474910	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatgtactacttcctgtcCatgttgtccttcagtgatgt	6	16	7	12	0	1	1	1	1	0	0	4	1	4	1	4	0	2	2	4	0	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:5474910C>A	uc010qzf.1	+	1	192	c.192C>A	c.(190-192)TCC>TCA	p.S64S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTTCCTGTCCATGTTGTCCT	0.547													33	85					9.65021e-13	1.28808e-12	1	0	A	5474910	A	A	5474910	2	1	136	1	0	0	0	0	0	0	0	1	11155	581	21	4		4	OR51I2	11	5474910	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	110467	5474910	129531606	293	24329											
OR52H1	390067	broad.mit.edu	37	chr11	5566075	5566075	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacagcacagaggatgtgtgCgtaggaaacagcaatgagaa	16	5	14	6	1	0	2	0	1	0	2	0	6	0	4	0	2	4	3	0	2	4	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:5566075C>T	uc010qzh.1	-	1	679	c.679G>A	c.(679-681)GCA>ACA	p.A227T	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGATGTGTGCGTAGGAAACA	0.498													16	44					0	0	0	0	T	5566075	T	T	5566075	3	4	136	1	0	0	0	0	1	0	0	0	11173	768	27	1	286	1	OR52H1	11	5566075	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	91165	5566075	129440441	294	24330											
OR56B1	387748	broad.mit.edu	37	chr11	5757697	5757697	+	5'Flank	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctgtggtggttccaaccTgtgataactgagaacaatac	11	13	9	8	0	1	2	0	2	1	1	2	3	2	2	2	2	4	1	2	2	5	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:5757697T>A	uc001mbt.1	+						TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|OR56B1_uc001mbs.1_5'UTR|OR56B1_uc009yev.1_5'UTR	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GGTTCCAACCTGTGATAACTG	0.313											OREG0003731	type=REGULATORY REGION|Gene=OR56B1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	11	47					0	0	0	0	A	5757697	A	A	5757697	1	1	136	0	1	0	0	0	0	0	0	0	11191	1595	55	5		5	OR56B1	11	5757697	5'Flank	SNP	T	TCGA-CR-7364-01A-11D-2012-08	191622	5757697	129248819	295	24331											
OR56A5	390084	broad.mit.edu	37	chr11	5989134	5989134	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaactggtagctctgattCaaggtgatgtcatcacaaga	14	10	9	8	0	4	3	3	2	1	1	4	3	4	3	0	2	2	2	0	2	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:5989134C>T	uc010qzu.1	-	1	591	c.591G>A	c.(589-591)TTG>TTA	p.L197L		NM_001146033	NP_001139505	P0C7T3	O56A5_HUMAN	olfactory receptor, family 56, subfamily A,	197	Extracellular (Potential).					integral to membrane|plasma membrane	olfactory receptor activity				0						AGCTCTGATTCAAGGTGATGT	0.418													3	7					0	0	0	0	T	5989134	T	T	5989134	2	4	136	1	0	0	0	0	0	0	0	1	11190	825	29	2		2	OR56A5	11	5989134	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	231437	5989134	129017382	296	24332											
OR10A6	390093	broad.mit.edu	37	chr11	7949914	7949914	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaggatgaaatacatctgtGcaaaacagcccccaaaagaa	19	5	8	9	0	1	2	0	1	1	1	1	4	1	3	2	1	4	1	2	1	8	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:7949914G>T	uc010rbh.1	-	1	296	c.296C>A	c.(295-297)GCA>GAA	p.A99E		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ATACATCTGTGCAAAACAGCC	0.428													21	59					2.32416e-17	3.31716e-17	1	0	T	7949914	T	T	7949914	3	4	136	1	0	0	0	0	1	0	0	0	10948	1319	46	4	651	4	OR10A6	11	7949914	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1960780	7949914	127056602	297	24333											
BBOX1	8424	broad.mit.edu	37	chr11	27147273	27147273	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacacaatatttgatgtgccTgttgaaagagttcagccttt	11	14	9	7	0	1	3	1	2	0	1	1	4	1	3	2	0	2	2	2	0	3	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:27147273T>A	uc001mre.1	+	8	1277	c.909T>A	c.(907-909)CCT>CCA	p.P303P	BBOX1_uc009yih.1_Silent_p.P303P|BBOX1_uc001mrg.1_Silent_p.P303P	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	303					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	ttgatgtgcctgttgaaagag	0.154													3	12					0	0	0	0	A	27147273	A	A	27147273	2	1	136	1	0	0	0	0	0	0	0	1	1336	1567	55	5		5	BBOX1	11	27147273	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	19197359	27147273	107859243	298	24334											
CCDC34	91057	broad.mit.edu	37	chr11	27379017	27379017	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caataaaccacacctcccatGgtgtcaggcggctttctggt	9	10	9	13	1	2	0	1	0	1	0	3	0	3	0	3	4	1	1	3	4	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:27379017G>C	uc001mrh.1	-	2	485	c.431C>G	c.(430-432)CCA>CGA	p.P144R	CCDC34_uc001mri.1_Missense_Mutation_p.P144R	NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	144											0						CACCTCCCATGGTGTCAGGCG	0.418													34	61					0	0	0	0	C	27379017	C	C	27379017	3	2	136	1	0	0	0	0	1	0	0	0	2820	1348	47	4	794	4	CCDC34	11	27379017	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	231744	27379017	107627499	299	24335											
TCP11L1	55346	broad.mit.edu	37	chr11	33094117	33094117	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcagtccagttcagagagaGctggaggaagttgctattaa	12	10	12	7	0	2	2	2	0	0	2	3	5	3	4	1	2	2	4	1	2	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:33094117G>A	uc001mud.2	+	10	1825	c.1425G>A	c.(1423-1425)GAG>GAA	p.E475E	TCP11L1_uc009yju.2_Silent_p.E290E|TCP11L1_uc010rei.1_Silent_p.E475E|TCP11L1_uc001mue.2_Silent_p.E475E|TCP11L1_uc001muf.1_RNA	NM_018393	NP_060863	Q9NUJ3	T11L1_HUMAN	t-complex 11 (mouse) like 1	475											0						TTCAGAGAGAGCTGGAGGAAG	0.493													47	124					0	0	0	0	A	33094117	A	A	33094117	2	1	136	1	0	0	0	0	0	0	0	1	15780	962	34	4		4	TCP11L1	11	33094117	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	5715100	33094117	101912399	300	24336											
PDHX	8050	broad.mit.edu	37	chr11	34988233	34988233	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacaaacgggcaagattaccGagtccagaccaactccagcc	15	4	8	14	2	0	2	0	0	0	2	2	3	2	2	5	1	5	1	5	1	5	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:34988233G>A	uc001mvt.2	+	6	1214	c.688G>A	c.(688-690)GAG>AAG	p.E230K	PDHX_uc010rep.1_Missense_Mutation_p.E215K|PDHX_uc010req.1_Intron	NM_003477	NP_003468	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	230					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			kidney(1)	1	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			CAAGATTACCGAGTCCAGACC	0.502													47	86					0	0	0	0	A	34988233	A	A	34988233	3	1	136	1	0	0	0	0	1	0	0	0	11721	1059	37	1	829	1	PDHX	11	34988233	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1894116	34988233	100018283	301	24337											
PAMR1	25891	broad.mit.edu	37	chr11	35463127	35463127	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggagttgttacaaaagaaaGacaccacggtgccaatttta	16	9	9	7	1	0	2	0	0	0	2	0	3	0	3	2	2	2	2	2	2	6	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:35463127G>C	uc001mwg.2	-	7	978	c.935C>G	c.(934-936)TCT>TGT	p.S312C	PAMR1_uc001mwf.2_Missense_Mutation_p.S329C|PAMR1_uc010rew.1_Missense_Mutation_p.S201C|PAMR1_uc010rex.1_Missense_Mutation_p.S272C	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	312	Sushi 1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						ACAAAAGAAAGACACCACGGT	0.493													37	99					0	0	0	0	C	35463127	C	C	35463127	3	2	136	1	0	0	0	0	1	0	0	0	11467	942	33	2	1247	2	PAMR1	11	35463127	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	474894	35463127	99543389	302	24338											
LRRC4C	57689	broad.mit.edu	37	chr11	40137641	40137641	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatgccatccggaacctcacGcaggtttttccgaacacaaa	12	8	8	13	3	1	0	1	0	0	0	3	3	3	1	4	2	3	2	4	2	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:40137641G>C	uc001mxa.1	-	2	2166	c.202C>G	c.(202-204)CGT>GGT	p.R68G	LRRC4C_uc001mxc.1_Missense_Mutation_p.R64G|LRRC4C_uc001mxd.1_Missense_Mutation_p.R64G|LRRC4C_uc001mxb.1_Missense_Mutation_p.R64G	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	68	LRRNT.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GGAACCTCACGCAGGTTTTTC	0.527													20	47					0	0	0	0	C	40137641	C	C	40137641	3	2	136	1	0	0	0	0	1	0	0	0	9058	1087	38	3	1724	3	LRRC4C	11	40137641	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4674514	40137641	94868875	303	24339											
ARFGAP2	84364	broad.mit.edu	37	chr11	47197400	47197400	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggaagtagaaggagctttAccgcattggcattcccgccg	10	8	13	10	3	0	1	0	0	0	1	1	3	1	3	3	3	2	4	3	3	4	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:47197400A>T	uc001ndt.2	-	3	279	c.264_splice	c.e3+1	p.A88_splice	ARFGAP2_uc010rha.1_5'Flank|ARFGAP2_uc010rhb.1_Splice_Site_p.A88_splice|ARFGAP2_uc001ndu.2_Splice_Site_p.A88_splice|ARFGAP2_uc010rhc.1_Intron|ARFGAP2_uc010rhd.1_Splice_Site_p.A88_splice|ARFGAP2_uc001ndv.1_Missense_Mutation_p.V89E	NM_032389	NP_115765	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating						protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			ovary(1)	1						AAGGAGCTTTACCGCATTGGC	0.537													9	34					0	0	0	0	T	47197400	T	T	47197400	5	4	136	1	0	0	0	0	0	0	1	0	850	405	14	5	1355	5	ARFGAP2	11	47197400	Splice_Site	SNP	A	TCGA-CR-7364-01A-11D-2012-08	7059759	47197400	87809116	304	24340											
MADD	8567	broad.mit.edu	37	chr11	47311587	47311587	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagaggacgatgcccggcagGacatcatcccggatgtggtc	9	6	14	12	3	1	1	1	0	0	1	3	5	2	4	2	5	1	1	2	5	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:47311587G>T	uc001ner.1	+	18	3177	c.2986G>T	c.(2986-2988)GAC>TAC	p.D996Y	MADD_uc001neq.2_Missense_Mutation_p.D976Y|MADD_uc001nev.1_Missense_Mutation_p.D933Y|MADD_uc001nes.1_Missense_Mutation_p.D953Y|MADD_uc001net.1_Missense_Mutation_p.D996Y|MADD_uc009yln.1_Missense_Mutation_p.D933Y|MADD_uc001neu.1_Missense_Mutation_p.D933Y|MADD_uc001nex.2_Missense_Mutation_p.D996Y|MADD_uc001nez.2_Missense_Mutation_p.D933Y|MADD_uc001new.2_Missense_Mutation_p.D976Y|MADD_uc009ylo.2_5'Flank	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	996					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		TGCCCGGCAGGACATCATCCC	0.587													18	49					5.3912e-06	6.2044e-06	1	0	T	47311587	T	T	47311587	3	4	136	1	0	0	0	0	1	0	0	0	9203	1174	41	2	3052	2	MADD	11	47311587	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	114187	47311587	87694929	305	24341											
OR5L1	219437	broad.mit.edu	37	chr11	55579097	55579097	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gattgcactgattcaggtcaGctctcggctccacaccccca	8	9	8	16	1	3	1	2	1	1	0	5	2	4	1	3	2	2	3	3	2	0	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:55579097G>T	uc001nhw.1	+	1	155	c.155G>T	c.(154-156)AGC>ATC	p.S52I		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				ATTCAGGTCAGCTCTCGGCTC	0.478													84	230					1.32764e-51	2.09842e-51	1	0	T	55579097	T	T	55579097	3	4	136	1	0	0	0	0	1	0	0	0	11224	971	34	4	157	4	OR5L1	11	55579097	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	8267510	55579097	79427419	306	24342											
SPRYD5	84767	broad.mit.edu	37	chr11	55653180	55653180	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttagctctgaggagcaaatAtgtgggatgcacagagagac	13	8	13	7	0	1	3	0	1	1	2	1	6	1	5	0	2	3	3	0	2	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:55653180A>T	uc010rip.1	+	2	368	c.276A>T	c.(274-276)ATA>ATT	p.I92I	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	92	B box-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				AGGAGCAAATATGTGGGATGC	0.493													6	24					0	0	0	0	T	55653180	T	T	55653180	2	4	136	1	0	0	0	0	0	0	0	1	15177	439	16	5		5	SPRYD5	11	55653180	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	74083	55653180	79353336	307	24343											
OR8J1	219477	broad.mit.edu	37	chr11	56128025	56128025	+	Frame_Shift_Del	DEL	G	-	-																															tatgaatgtgccacccaactGggagggttcttgttctttat																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:56128025delG	uc010rjh.1	+	1	303	c.303delG	c.(301-303)CTGfs	p.L101fs		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	101	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CCACCCAACTGGGAGGGTTCT	0.413													---	---	---								-	56128025	-	-	56128025	7	5	136	1	0	1	0	1	0	0	0	0	11295	1335	47	0	305	0	OR8J1	11	56128025	Frame_Shift_Del	DEL	G	TCGA-CR-7364-01A-11D-2012-08	474845	56128025	78878491	308	24344											
CTNND1	1500	broad.mit.edu	37	chr11	57559055	57559055	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgctggaggaggaacggcgCcacgtctcggcgcagctgga	7	4	18	12	6	1	0	0	0	1	0	2	4	1	4	1	6	2	3	1	6	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:57559055C>G	uc001nmc.3	+	3	676	c.105C>G	c.(103-105)CGC>CGG	p.R35R	CTNND1_uc001nlf.1_Silent_p.R35R|CTNND1_uc001nlh.1_Silent_p.R35R|CTNND1_uc001nlu.3_Intron|CTNND1_uc001nlt.3_Intron|CTNND1_uc001nls.3_Intron|CTNND1_uc001nlw.3_Intron|CTNND1_uc001nmf.3_Silent_p.R35R|CTNND1_uc001nmd.3_5'UTR|CTNND1_uc001nlk.3_5'UTR|CTNND1_uc001nme.3_Silent_p.R35R|CTNND1_uc001nll.3_5'UTR|CTNND1_uc001nmg.3_5'UTR|CTNND1_uc001nlj.3_5'UTR|CTNND1_uc001nlr.3_5'UTR|CTNND1_uc001nlp.3_5'UTR|CTNND1_uc001nlx.3_Intron|CTNND1_uc001nlz.3_Intron|CTNND1_uc009ymn.2_Intron|CTNND1_uc001nlm.3_Silent_p.R35R|CTNND1_uc001nly.3_Intron|CTNND1_uc001nmb.3_Intron|CTNND1_uc001nma.3_Intron|CTNND1_uc001nmi.3_Intron|CTNND1_uc001nmh.3_Silent_p.R35R|CTNND1_uc001nlq.3_Intron|CTNND1_uc001nln.3_Silent_p.R35R|CTNND1_uc001nli.3_Silent_p.R35R|CTNND1_uc001nlo.3_Intron|CTNND1_uc001nlv.3_Intron	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	35	Potential.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				AGGAACGGCGCCACGTCTCGG	0.637													9	30					0	0	0	0	G	57559055	G	G	57559055	2	3	136	1	0	0	0	0	0	0	0	1	4036	726	26	4		4	CTNND1	11	57559055	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1431030	57559055	77447461	309	24345											
OR6Q1	219952	broad.mit.edu	37	chr11	57799217	57799217	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttttctttatgtatgtcCagaccaaggtgacctcctcc	7	15	6	13	0	2	2	0	1	2	1	5	2	5	2	5	1	0	1	5	1	3	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:57799217C>A	uc010rjz.1	+	1	793	c.793C>A	c.(793-795)CAG>AAG	p.Q265K	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				TATGTATGTCCAGACCAAGGT	0.502													52	147					1.11015e-26	1.67744e-26	1	0	A	57799217	A	A	57799217	3	1	136	1	0	0	0	0	1	0	0	0	11262	595	21	4	795	4	OR6Q1	11	57799217	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	240162	57799217	77207299	310	24346											
DTX4	23220	broad.mit.edu	37	chr11	58972335	58972335	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ataatgtgctggctgaactgGctgcccagggcatctctgag	8	10	13	10	0	1	2	0	2	1	0	2	2	1	2	1	3	3	4	1	3	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:58972335G>A	uc001nns.2	+	9	2070	c.1813G>A	c.(1813-1815)GCT>ACT	p.A605T	DTX4_uc001nnr.2_Missense_Mutation_p.A499T	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	605					Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				GGCTGAACTGGCTGCCCAGGG	0.552													4	13					0	0	0	0	A	58972335	A	A	58972335	3	1	136	1	0	0	0	0	1	0	0	0	4819	1203	42	4	1847	4	DTX4	11	58972335	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1173118	58972335	76034181	311	24347											
AHNAK	79026	broad.mit.edu	37	chr11	62297619	62297619	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaccttcaatattcacatCtggaacttcagcatccattt	11	14	5	11	0	4	0	3	0	1	0	5	2	5	2	2	2	2	1	2	2	3	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:62297619C>G	uc001ntl.2	-	5	4570	c.4270G>C	c.(4270-4272)GAT>CAT	p.D1424H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1424					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATATTCACATCTGGAACTTCA	0.468													81	228					0	0	0	0	G	62297619	G	G	62297619	3	3	136	1	0	0	0	0	1	0	0	0	414	913	32	2	13522	2	AHNAK	11	62297619	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3325284	62297619	72708897	312	24348											
GANAB	23193	broad.mit.edu	37	chr11	62393907	62393907	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatccagaaagagctctcCttgagctgtaccctgagcaa	12	9	8	12	0	2	4	1	2	1	2	4	4	3	4	3	0	4	4	3	0	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:62393907C>T	uc001nub.2	-	22	2557	c.2524G>A	c.(2524-2526)GGA>AGA	p.G842R	GANAB_uc001ntz.2_Missense_Mutation_p.G29R|GANAB_uc001nua.2_Missense_Mutation_p.G864R|GANAB_uc001nuc.2_Missense_Mutation_p.G745R|GANAB_uc010rma.1_Missense_Mutation_p.G750R|GANAB_uc010rmb.1_Missense_Mutation_p.G728R	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	842					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						AAGAGCTCTCCTTGAGCTGTA	0.557													20	50					0	0	0	0	T	62393907	T	T	62393907	3	4	136	1	0	0	0	0	1	0	0	0	6268	690	24	4	322	4	GANAB	11	62393907	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	96288	62393907	72612609	313	24349											
KCNK7	10089	broad.mit.edu	37	chr11	65360635	65360635	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctgcggcagctcagagaaGgtctccactgccagcagcat	10	6	11	14	1	2	1	1	0	1	1	3	2	2	1	3	2	5	4	3	2	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:65360635G>C	uc001oes.2	-	3	989	c.765C>G	c.(763-765)ACC>ACG	p.T255T	KCNK7_uc001oeq.2_3'UTR|KCNK7_uc001oer.2_3'UTR|KCNK7_uc001oeu.2_3'UTR	NM_033347	NP_203133	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7 isoform	255	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						GCTCAGAGAAGGTCTCCACTG	0.612													6	20					0	0	0	0	C	65360635	C	C	65360635	2	2	136	1	0	0	0	0	0	0	0	1	8110	987	35	4		4	KCNK7	11	65360635	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2966728	65360635	69645881	314	24350											
RELA	5970	broad.mit.edu	37	chr11	65421990	65421990	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggggggcctctgggccccTgtcactaggcgagttatagc	5	9	15	12	2	2	0	1	0	1	0	3	1	2	0	3	5	1	1	3	5	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:65421990T>A	uc001ofg.2	-	11	1655	c.1515A>T	c.(1513-1515)ACA>ACT	p.T505T	RELA_uc001ofh.2_Silent_p.T502T|RELA_uc010ron.1_Silent_p.T516T|RELA_uc009yqr.2_Silent_p.T452T|RELA_uc001ofe.2_3'UTR|RELA_uc001off.2_Intron	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	505					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4						TCTGGGCCCCTGTCACTAGGC	0.632													17	42					0	0	0	0	A	65421990	A	A	65421990	2	1	136	1	0	0	0	0	0	0	0	1	13281	1567	55	5		5	RELA	11	65421990	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	61355	65421990	69584526	315	24351											
ACY3	91703	broad.mit.edu	37	chr11	67414349	67414349	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcggcagccggatgtggctgCcgggttggccagcacaggca	6	5	18	12	3	0	0	0	0	0	0	0	1	0	1	3	6	3	5	3	6	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:67414349C>G	uc001omq.2	-	3	337	c.166G>C	c.(166-168)GCA>CCA	p.A56P		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	56					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	GATGTGGCTGCCGGGTTGGCC	0.657													4	19					0	0	0	0	G	67414349	G	G	67414349	3	3	136	1	0	0	0	0	1	0	0	0	227	739	26	4	817	4	ACY3	11	67414349	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1992359	67414349	67592167	316	24352											
SUV420H1	51111	broad.mit.edu	37	chr11	67926430	67926430	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgaagcattcttttgctcCagccgcttgcaatgatttct	7	16	7	11	1	2	2	0	2	2	0	3	2	3	2	2	0	4	4	2	0	2	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:67926430C>T	uc001onm.1	-	11	1639	c.1383G>A	c.(1381-1383)CTG>CTA	p.L461L	SUV420H1_uc009yse.1_Silent_p.L47L|SUV420H1_uc001onn.1_Silent_p.L289L|SUV420H1_uc009ysf.2_Silent_p.L221L	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						TCTTTTGCTCCAGCCGCTTGC	0.348													16	69					0	0	0	0	T	67926430	T	T	67926430	2	4	136	1	0	0	0	0	0	0	0	1	15480	581	21	4		4	SUV420H1	11	67926430	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	512081	67926430	67080086	317	24353											
EED	8726	broad.mit.edu	37	chr11	85977217	85977217	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaagagaatgatgaatgcAattaaggaatcttatgatta	18	12	8	3	0	2	4	1	3	1	1	2	6	2	5	0	1	1	1	0	1	8	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:85977217A>T	uc001pbp.2	+	8	1276	c.819A>T	c.(817-819)GCA>GCT	p.A273A	EED_uc010rtm.1_Silent_p.A273A|EED_uc001pbq.2_Silent_p.A273A|EED_uc001pbr.2_Silent_p.A273A|EED_uc001pbs.2_Intron|EED_uc010rtn.1_RNA	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	273	Interaction with EZH2 (By similarity).|WD 4.|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				TGATGAATGCAATTAAGGAAT	0.299													24	91					0	0	0	0	T	85977217	T	T	85977217	2	4	136	1	0	0	0	0	0	0	0	1	4944	117	5	5		5	EED	11	85977217	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	18050787	85977217	49029299	318	24354											
FOLH1B	219595	broad.mit.edu	37	chr11	89402587	89402587	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacagaaaaatgggtggctCagcaccaccagatagcagct	15	5	10	11	0	1	2	1	0	0	2	1	2	1	2	2	2	4	4	2	2	4	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:89402587C>T	uc001pda.2	+	3	537	c.11C>T	c.(10-12)TCA>TTA	p.S4L		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	4					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						ATGGGTGGCTCAGCACCACCA	0.378													15	37					0	0	0	0	T	89402587	T	T	89402587	3	4	136	1	0	0	0	0	1	0	0	0	6012	838	29	2	13	2	FOLH1B	11	89402587	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3425370	89402587	45603929	319	24355											
HEPHL1	341208	broad.mit.edu	37	chr11	93797618	93797618	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatcaaacatttctgcacCaaccctgattcagttgacaa	15	11	4	11	0	3	2	2	2	1	0	3	2	3	2	2	0	3	2	2	0	5	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:93797618C>A	uc001pep.2	+	4	907	c.750C>A	c.(748-750)ACC>ACA	p.T250T		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	250	Plastocyanin-like 2.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ATTTCTGCACCAACCCTGATT	0.408													12	27					0.00185496	0.00202181	1	0	A	93797618	A	A	93797618	2	1	136	1	0	0	0	0	0	0	0	1	7094	581	21	4		4	HEPHL1	11	93797618	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	4395031	93797618	41208898	320	24356											
FOLR4	390243	broad.mit.edu	37	chr11	94040453	94040453	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccaactggcgtggtggctgGgactggagtcagggtgagtg	6	9	19	7	1	1	1	1	1	0	0	2	3	2	3	1	6	1	1	1	6	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:94040453G>A	uc010rud.1	+	3	450	c.450G>A	c.(448-450)TGG>TGA	p.W150*		NM_001080486	NP_001073955	A6ND01	FOLR4_HUMAN	folate receptor 4 (delta) homolog	157						extracellular region	folic acid binding|receptor activity			ovary(1)	1						GTGGTGGCTGGGACTGGAGTC	0.587													4	22					0	0	0	0	A	94040453	A	A	94040453	4	1	136	1	0	0	0	0	0	1	0	0	6016	1241	43	4	460	4	FOLR4	11	94040453	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	242835	94040453	40966063	321	24357											
GUCY1A2	2977	broad.mit.edu	37	chr11	106579253	106579253	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttactggtaagtggttgggCtgacattgatgcgccgaggg	7	11	16	7	2	0	2	0	2	0	0	0	3	0	2	1	4	2	3	1	4	2	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:106579253C>A	uc001pjg.1	-	7	2366	c.1976G>T	c.(1975-1977)AGC>ATC	p.S659I	GUCY1A2_uc010rvo.1_Missense_Mutation_p.S680I|GUCY1A2_uc009yxn.1_Missense_Mutation_p.S690I	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	659					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		AGTGGTTGGGCTGACATTGAT	0.502													15	42					2.31682e-05	2.62715e-05	1	0	A	106579253	A	A	106579253	3	1	136	1	0	0	0	0	1	0	0	0	6932	797	28	4	230	4	GUCY1A2	11	106579253	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	12538800	106579253	28427263	322	24358											
SIK3	23387	broad.mit.edu	37	chr11	116797940	116797940	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagtacagttctcacctgctAttttgatattcagattggca	10	15	7	9	0	2	2	2	1	1	1	3	2	2	2	1	1	2	4	1	1	3	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:116797940A>T	uc001ppy.2	-	4	473	c.437T>A	c.(436-438)ATA>AAA	p.I146K	SIK3_uc001ppz.2_Missense_Mutation_p.I45K|SIK3_uc001pqa.2_Missense_Mutation_p.I146K	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	146	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						CTCACCTGCTATTTTGATATT	0.398													25	58					0	0	0	0	T	116797940	T	T	116797940	3	4	136	1	0	0	0	0	1	0	0	0	14384	449	16	5	3434	5	SIK3	11	116797940	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	10218687	116797940	18208576	323	24359											
SORL1	6653	broad.mit.edu	37	chr11	121485640	121485640	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgggccaagactgacttggGggatagccctctggcatttg	7	10	14	10	0	1	2	0	1	1	1	1	3	1	3	2	4	1	1	2	4	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:121485640G>T	uc001pxx.2	+	41	5560	c.5480G>T	c.(5479-5481)GGG>GTG	p.G1827V	SORL1_uc010rzp.1_Missense_Mutation_p.G673V|SORL1_uc010rzq.1_Missense_Mutation_p.G442V	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1827	Extracellular (Potential).|Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ACTGACTTGGGGGATAGCCCT	0.517													30	56					5.77227e-19	8.37386e-19	1	0	T	121485640	T	T	121485640	3	4	136	1	0	0	0	0	1	0	0	0	14998	1232	43	4	5642	4	SORL1	11	121485640	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4687700	121485640	13520876	324	24360											
CRTAM	56253	broad.mit.edu	37	chr11	122709301	122709301	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggcatggttccccttgcaagGtaaggacttagagttatttt	9	14	11	7	0	0	1	0	0	0	1	1	2	1	2	2	4	1	5	2	4	4	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:122709301G>A	uc001pyj.2	+	1	46	c.46_splice	c.e1+1	p.E16_splice		NM_019604	NP_062550	O95727	CRTAM_HUMAN	class-I MHC-restricted T cell associated						cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			ovary(1)	1		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		CCCTTGCAAGGTAAGGACTTA	0.458													16	51					0	0	0	0	A	122709301	A	A	122709301	5	1	136	1	0	0	0	0	0	0	1	0	3912	1275	44	4	49	4	CRTAM	11	122709301	Splice_Site	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1223661	122709301	12297215	325	24361											
OR10G8	219869	broad.mit.edu	37	chr11	123900617	123900617	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctatctccttccacagctgCatggctcagctctatttctt	6	15	6	14	0	4	0	1	0	3	0	6	0	5	0	2	1	3	5	2	1	2	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:123900617C>T	uc001pzp.1	+	1	288	c.288C>T	c.(286-288)TGC>TGT	p.C96C		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TCCACAGCTGCATGGCTCAGC	0.527													41	130					0	0	0	0	T	123900617	T	T	123900617	2	4	136	1	0	0	0	0	0	0	0	1	10957	718	25	4		4	OR10G8	11	123900617	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1191316	123900617	11105899	326	24362											
OR8G2	26492	broad.mit.edu	37	chr11	124095640	124095640	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctcagtggtctgtccttCattgatatctgccattccac	6	16	6	13	0	4	1	2	1	2	0	7	1	7	1	4	1	1	0	4	1	1	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:124095640C>T	uc010saf.1	+	1	243	c.243C>T	c.(241-243)TTC>TTT	p.F81F		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	81						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GTCTGTCCTTCATTGATATCT	0.463													50	117					0	0	0	0	T	124095640	T	T	124095640	2	4	136	1	0	0	0	0	0	0	0	1	11289	825	29	2		2	OR8G2	11	124095640	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	195023	124095640	10910876	327	24363											
SNX19	399979	broad.mit.edu	37	chr11	130785267	130785267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agtcgcccggcagtaagcctCccagaggtgggaaggctcaa	10	5	14	12	2	1	1	1	0	0	1	3	2	2	2	3	4	1	3	3	4	3	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:130785267C>T	uc001qgk.3	-	1	1116	c.568G>A	c.(568-570)GAG>AAG	p.E190K	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Missense_Mutation_p.E190K|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	190	PXA.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		CAGTAAGCCTCCCAGAGGTGG	0.572													7	38					0	0	0	0	T	130785267	T	T	130785267	3	4	136	1	0	0	0	0	1	0	0	0	14954	864	30	2	2454	2	SNX19	11	130785267	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	6689627	130785267	4221249	328	24364											
NTM	50863	broad.mit.edu	37	chr11	132180115	132180115	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagaattccagtggtacaaGgatgacaaaaggtaaagctt	16	8	11	6	0	0	2	0	1	0	1	1	3	1	3	1	3	2	4	1	3	7	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr11:132180115G>A	uc001qgp.2	+	5	1435	c.771G>A	c.(769-771)AAG>AAA	p.K257K	NTM_uc001qgm.2_Silent_p.K257K|NTM_uc010sch.1_Silent_p.K248K|NTM_uc010sci.1_Silent_p.K257K|NTM_uc010scj.1_Silent_p.K216K|NTM_uc001qgo.2_Silent_p.K257K|NTM_uc001qgq.2_Silent_p.K257K|NTM_uc001qgr.2_5'UTR	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	257	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						AGTGGTACAAGGATGACAAAA	0.512													53	137					0	0	0	0	A	132180115	A	A	132180115	2	1	136	1	0	0	0	0	0	0	0	1	10753	991	35	4		4	NTM	11	132180115	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1394848	132180115	2826401	329	24365											
ADIPOR2	79602	broad.mit.edu	37	chr12	1895200	1895200	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctccaggagtttcgtttcAtgatcggcgggggctgcagt	6	11	14	10	3	1	1	1	1	0	0	4	2	2	2	2	4	1	4	2	4	0	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:1895200A>G	uc001qjm.2	+	8	1320	c.1123A>G	c.(1123-1125)ATG>GTG	p.M375V	ADIPOR2_uc001qjn.2_Missense_Mutation_p.M375V	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	375	Extracellular (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)			GTTTCGTTTCATGATCGGCGG	0.537													90	101					0	0	0	0	G	1895200	G	G	1895200	3	3	136	1	0	0	0	0	1	0	0	0	319	217	8	5	1149	5	ADIPOR2	12	1895200	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08		1895200	131956695	330	24366											
TEAD4	7004	broad.mit.edu	37	chr12	3147246	3147246	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccacgaaggtctgctcttTcggcaagcaggtggtggaga	8	9	14	10	2	2	1	0	0	2	1	4	3	3	1	1	5	2	3	1	5	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:3147246T>A	uc010sej.1	+	11	1284	c.1007T>A	c.(1006-1008)TTC>TAC	p.F336Y	TEAD4_uc010sek.1_Missense_Mutation_p.F293Y|TEAD4_uc001qln.2_Missense_Mutation_p.F208Y	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	337				F->A: Reduced interaction with YAP1.	hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			GTCTGCTCTTTCGGCAAGCAG	0.577													31	112					0	0	0	0	A	3147246	A	A	3147246	3	1	136	1	0	0	0	0	1	0	0	0	15807	1783	62	5	1044	5	TEAD4	12	3147246	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	1252046	3147246	130704649	331	24367											
DYRK4	8798	broad.mit.edu	37	chr12	4702204	4702204	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taagaaccagctgtctccatAtgaacaaagtgaaatcctgg	15	9	8	9	0	1	3	0	2	1	1	3	3	2	3	3	1	3	1	3	1	6	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:4702204A>G	uc001qmx.2	+	4	315	c.155A>G	c.(154-156)TAT>TGT	p.Y52C	DYRK4_uc009zeh.1_Missense_Mutation_p.Y167C|DYRK4_uc001qmy.1_Missense_Mutation_p.Y52C	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	52						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			CTGTCTCCATATGAACAAAGT	0.483													29	103					0	0	0	0	G	4702204	G	G	4702204	3	3	136	1	0	0	0	0	1	0	0	0	4880	449	16	5	161	5	DYRK4	12	4702204	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	1554958	4702204	129149691	332	24368											
NCAPD2	9918	broad.mit.edu	37	chr12	6623493	6623493	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattaatcaccagaagaaccGccccactcgggaagccataa	15	5	7	14	2	1	2	1	0	0	2	2	3	1	3	5	1	2	0	5	1	5	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:6623493G>T	uc001qoo.2	+	7	696	c.650G>T	c.(649-651)CGC>CTC	p.R217L	NCAPD2_uc009zen.1_Missense_Mutation_p.R89L|NCAPD2_uc010sfd.1_Missense_Mutation_p.R172L	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	217	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						CAGAAGAACCGCCCCACTCGG	0.488													47	223					4.18559e-23	6.26318e-23	1	0	T	6623493	T	T	6623493	3	4	136	1	0	0	0	0	1	0	0	0	10259	1087	38	3	672	3	NCAPD2	12	6623493	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1921289	6623493	127228402	333	24369											
LEPREL2	10536	broad.mit.edu	37	chr12	6940435	6940435	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgtcctgctcttctacccGgaggatgaggctgccaagag	8	9	13	11	1	2	2	0	1	2	1	3	4	3	4	3	3	3	2	3	3	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:6940435G>A	uc001qra.1	+	7	1075	c.1041G>A	c.(1039-1041)CCG>CCA	p.P347P	LEPREL2_uc001qqz.1_Silent_p.P154P|LEPREL2_uc001qrb.1_Silent_p.P154P	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	347	TPR 4.				negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCTTCTACCCGGAGGATGAGG	0.587													25	154					0	0	0	0	A	6940435	A	A	6940435	2	1	136	1	0	0	0	0	0	0	0	1	8771	1103	39	1		1	LEPREL2	12	6940435	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	316942	6940435	126911460	334	24370											
CD163	9332	broad.mit.edu	37	chr12	7639140	7639141	+	Frame_Shift_Ins	INS	-	C	C																															ttgtgcctgcaattttgctgINScccccagccgtgtgaatggc																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:7639140_7639141insC	uc001qsz.3	-	10	2540_2541	c.2412_2413insG	c.(2410-2415)GGGCAGfs	p.G804fs	CD163_uc001qta.3_Frame_Shift_Ins_p.G804fs|CD163_uc009zfw.2_Frame_Shift_Ins_p.G837fs	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	804_805	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CAATTTTGCTGCCCCCAGCCGT	0.48													---	---	---								C	7639141	C	C	7639140	7	5	136	1	0	1	1	0	0	0	0	0	2982	1328	46	0	1085	0	CD163	12	7639140	Frame_Shift_Ins	INS	-	TCGA-CR-7364-01A-11D-2012-08	698705	7639140	126212755	335	24371											
PZP	5858	broad.mit.edu	37	chr12	9356471	9356471	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttacagtcactgtctcatTcaggtggctcagaaggacac	11	10	9	11	0	4	1	4	0	1	1	5	2	4	2	0	3	1	1	0	3	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:9356471T>A	uc001qvl.2	-	2	189	c.160A>T	c.(160-162)AAT>TAT	p.N54Y	PZP_uc009zgl.2_5'UTR	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						ACTGTCTCATTCAGGTGGCTC	0.532													31	105					0	0	0	0	A	9356471	A	A	9356471	3	1	136	1	0	0	0	0	1	0	0	0	12934	1783	62	5	4428	5	PZP	12	9356471	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	1717331	9356471	124495424	336	24372											
GRIN2B	2904	broad.mit.edu	37	chr12	14018983	14018983	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggaaatcatctttctcgtGggcatccttgatggccacct	7	13	10	11	1	3	1	1	1	2	0	5	2	4	2	3	3	0	1	3	3	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:14018983G>A	uc001rbt.2	-	2	339	c.160C>T	c.(160-162)CAC>TAC	p.H54Y		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	54	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCTTTCTCGTGGGCATCCTTG	0.572													23	113					0	0	0	0	A	14018983	A	A	14018983	3	1	136	1	0	0	0	0	1	0	0	0	6819	1348	47	4	4342	4	GRIN2B	12	14018983	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4662512	14018983	119832912	337	24373											
SLCO1C1	53919	broad.mit.edu	37	chr12	20893179	20893179	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atccggaaattcctcaggcaTagtgggaagatgtcagaaag	14	8	12	7	1	2	2	2	0	0	2	4	4	4	4	2	3	0	1	2	3	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:20893179T>C	uc001rej.3	+	13	1965	c.1610T>C	c.(1609-1611)ATA>ACA	p.I537T	SLCO1C1_uc010sii.1_Missense_Mutation_p.I537T|SLCO1C1_uc010sij.1_Missense_Mutation_p.I488T|SLCO1C1_uc009zip.2_Missense_Mutation_p.I371T|SLCO1C1_uc001rei.2_Missense_Mutation_p.I537T|SLCO1C1_uc010sik.1_Missense_Mutation_p.I419T	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	537	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TCCTCAGGCATAGTGGGAAGA	0.388													18	72					0	0	0	0	C	20893179	C	C	20893179	3	2	136	1	0	0	0	0	1	0	0	0	14789	1406	49	5	1652	5	SLCO1C1	12	20893179	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	6874196	20893179	112958716	338	24374											
PDZRN4	29951	broad.mit.edu	37	chr12	41966994	41966994	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagcaaggttgtagcgctGaaagcaaggagaaggtttta	13	9	14	5	1	0	3	0	2	0	1	0	4	0	3	0	3	3	6	0	3	6	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:41966994G>T	uc010skn.1	+	10	1884	c.1816G>T	c.(1816-1818)GAA>TAA	p.E606*	PDZRN4_uc001rmq.3_Nonsense_Mutation_p.E547*|PDZRN4_uc009zjz.2_Nonsense_Mutation_p.E545*|PDZRN4_uc001rmr.2_Nonsense_Mutation_p.E432*	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	805							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTGTAGCGCTGAAAGCAAGGA	0.517													42	124					4.16155e-14	5.66483e-14	1	0	T	41966994	T	T	41966994	4	4	136	1	0	0	0	0	0	1	0	0	11764	1291	45	2	2524	2	PDZRN4	12	41966994	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	21073815	41966994	91884901	339	24375											
COL2A1	1280	broad.mit.edu	37	chr12	48368576	48368576	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtagacgcaagtctcgccaGtctccatgttgcagaaaacc	11	8	10	12	2	2	2	0	0	2	2	4	2	2	2	3	1	2	4	3	1	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:48368576G>C	uc001rqu.2	-	52	4137	c.3956C>G	c.(3955-3957)ACT>AGT	p.T1319S	COL2A1_uc001rqt.2_Missense_Mutation_p.T100S|COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.T1250S	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	1319	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	AGTCTCGCCAGTCTCCATGTT	0.547													36	123					0	0	0	0	C	48368576	C	C	48368576	3	2	136	1	0	0	0	0	1	0	0	0	3702	1029	36	4	519	4	COL2A1	12	48368576	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	6401582	48368576	85483319	340	24376											
COL2A1	1280	broad.mit.edu	37	chr12	48389061	48389061	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atcaccaggctttccaggggGaccaggaggaccacggggac	10	4	15	12	1	1	0	1	0	0	0	2	4	2	4	4	7	0	1	4	7	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:48389061G>C	uc001rqu.2	-	11	920	c.739C>G	c.(739-741)CCC>GCC	p.P247A	COL2A1_uc001rqv.2_Missense_Mutation_p.P178A	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	247	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TTTCCAGGGGGACCAGGAGGA	0.502													19	112					0	0	0	0	C	48389061	C	C	48389061	3	2	136	1	0	0	0	0	1	0	0	0	3702	1174	41	2	3900	2	COL2A1	12	48389061	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	20485	48389061	85462834	341	24377											
ASB8	140461	broad.mit.edu	37	chr12	48543741	48543741	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctcatctttctctgctgcaTagtggagggctgttcggtta	5	15	11	10	1	3	0	1	0	2	0	5	1	3	1	1	3	2	5	1	3	2	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:48543741T>C	uc001rrh.2	-	4	444	c.275A>G	c.(274-276)TAT>TGT	p.Y92C	ASB8_uc010slr.1_Missense_Mutation_p.Y88C	NM_024095	NP_077000	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box-containing 8	92	ANK 2.				intracellular signal transduction	cytoplasm|nucleus				kidney(1)	1						CTCTGCTGCATAGTGGAGGGC	0.498													22	50					0	0	0	0	C	48543741	C	C	48543741	3	2	136	1	0	0	0	0	1	0	0	0	1031	1406	49	5	595	5	ASB8	12	48543741	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	154680	48543741	85308154	342	24378											
CSAD	51380	broad.mit.edu	37	chr12	53563908	53563908	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gatcctcggggaccattttcCctctgaaaaagaaaatgcag	13	9	9	10	1	1	2	0	1	1	1	4	4	3	3	3	2	1	1	3	2	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:53563908C>T	uc001sby.2	-	9	776	c.650G>A	c.(649-651)GGG>GAG	p.G217E	CSAD_uc001sbw.2_Missense_Mutation_p.G70E|CSAD_uc009zmt.2_5'UTR|CSAD_uc010snx.1_Missense_Mutation_p.G244E|CSAD_uc001sbz.2_Missense_Mutation_p.G217E|CSAD_uc009zmu.2_Missense_Mutation_p.G70E|CSAD_uc001sca.3_RNA	NM_015989	NP_057073	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	217					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			ovary(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GACCATTTTCCCTCTGAAAAA	0.522									Hereditary_Prostate_Cancer				20	49					0	0	0	0	T	53563908	T	T	53563908	3	4	136	1	0	0	0	0	1	0	0	0	3940	623	22	4	863	4	CSAD	12	53563908	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5020167	53563908	80287987	343	24379											
OR10A7	121364	broad.mit.edu	37	chr12	55615713	55615713	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaagtgaaaggggctgtcaAgaggacaatcactcaaaaag	17	6	12	6	0	3	3	3	2	0	1	3	4	3	4	0	3	0	1	0	3	6	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:55615713A>G	uc010spf.1	+	1	905	c.905A>G	c.(904-906)AAG>AGG	p.K302R		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						GGGGCTGTCAAGAGGACAATC	0.428													5	35					0	0	0	0	G	55615713	G	G	55615713	3	3	136	1	0	0	0	0	1	0	0	0	10949	72	3	5	907	5	OR10A7	12	55615713	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	2051805	55615713	78236182	344	24380											
MARS	4141	broad.mit.edu	37	chr12	57881758	57881758	+	5'Flank	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atagtctactttccggtagcGgtgccagggcagtggcctaa	8	10	13	10	2	1	0	0	0	1	0	2	0	2	0	3	4	3	2	3	4	4	5	rs146191545	by1000genomes	TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:57881758G>T	uc001sog.2	+						ARHGAP9_uc001sod.2_Intron|ARHGAP9_uc001soe.1_Intron|MARS_uc001sof.1_RNA|MARS_uc010srp.1_5'UTR|MARS_uc010srq.1_5'UTR	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase						methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	TTCCGGTAGCGGTGCCAGGGC	0.577													19	32					2.35188e-11	3.07286e-11	1	0	T	57881758	T	T	57881758	1	4	136	0	1	0	0	0	0	0	0	0	9369	1131	39	3		3	MARS	12	57881758	5'Flank	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2266045	57881758	75970137	345	24381											
NAV3	89795	broad.mit.edu	37	chr12	78444708	78444708	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgctggctatcctcgcaGtggtaccagtcgattcatcc	6	11	12	12	2	1	0	1	0	0	0	5	1	3	0	3	3	2	4	3	3	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:78444708G>C	uc001syp.2	+	11	2470	c.2297G>C	c.(2296-2298)AGT>ACT	p.S766T	NAV3_uc001syo.2_Missense_Mutation_p.S766T|NAV3_uc010sub.1_Missense_Mutation_p.S266T	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	766						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TATCCTCGCAGTGGTACCAGT	0.587										HNSCC(70;0.22)			7	32					0	0	0	0	C	78444708	C	C	78444708	3	2	136	1	0	0	0	0	1	0	0	0	10238	1029	36	4	2339	4	NAV3	12	78444708	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	20562950	78444708	55407187	346	24382											
PLXNC1	10154	broad.mit.edu	37	chr12	94603380	94603380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttttaggtgcacttttcaagGagattgtgtacattcagaga	11	15	10	5	0	2	2	2	0	0	2	2	4	2	2	0	2	2	2	0	2	3	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:94603380G>A	uc001tdc.2	+	5	1703	c.1454G>A	c.(1453-1455)GGA>GAA	p.G485E		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	485	Extracellular (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						ACTTTTCAAGGAGATTGTGTA	0.388													36	149					0	0	0	0	A	94603380	A	A	94603380	3	1	136	1	0	0	0	0	1	0	0	0	12181	1174	41	2	1472	2	PLXNC1	12	94603380	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	16158672	94603380	39248515	347	24383											
PLXNC1	10154	broad.mit.edu	37	chr12	94641821	94641821	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgcagtatcgggaggaccCcagattcacggggtatcggg	8	7	15	11	3	1	1	1	0	0	1	3	3	1	3	3	5	1	3	3	5	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:94641821C>G	uc001tdc.2	+	13	2780	c.2531C>G	c.(2530-2532)CCC>CGC	p.P844R		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	844	Extracellular (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						CGGGAGGACCCCAGATTCACG	0.493													19	58					0	0	0	0	G	94641821	G	G	94641821	3	3	136	1	0	0	0	0	1	0	0	0	12181	623	22	4	2581	4	PLXNC1	12	94641821	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	38441	94641821	39210074	348	24384											
ACTR6	64431	broad.mit.edu	37	chr12	100599500	100599500	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagacaagtttgggattaccTttttggaaaagaaatgtatc	14	13	10	4	0	0	2	0	0	0	2	1	5	0	4	1	2	1	2	1	2	6	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:100599500T>A	uc001thb.1	+	3	289	c.233T>A	c.(232-234)CTT>CAT	p.L78H	ACTR6_uc010svh.1_Missense_Mutation_p.L78H|ACTR6_uc001thc.1_5'UTR|ACTR6_uc001thd.1_Missense_Mutation_p.L78H|ACTR6_uc009ztu.1_5'UTR|ACTR6_uc001the.1_5'UTR|ACTR6_uc001thf.1_5'UTR|uc001thg.1_Intron	NM_022496	NP_071941	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog	78						cytoplasm|cytoskeleton				ovary(1)	1						TGGGATTACCTTTTTGGAAAA	0.209													9	23					0	0	0	0	A	100599500	A	A	100599500	3	1	136	1	0	0	0	0	1	0	0	0	216	1609	56	5	243	5	ACTR6	12	100599500	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	5957679	100599500	33252395	349	24385											
PAH	5053	broad.mit.edu	37	chr12	103232972	103232972	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tttactttattttctggaggGcactgcaaaggattccaatt	10	16	8	7	0	1	0	0	0	1	0	2	2	2	2	1	3	2	2	1	3	4	8	rs76542238		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:103232972G>A	uc001tjq.1	-	14	1812	c.1340C>T	c.(1339-1341)GCC>GTC	p.A447V		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	447			A -> D (in PKU).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	TTTCTGGAGGGCACTGCAAAG	0.398													12	34					0	0	0	0	A	103232972	A	A	103232972	3	1	136	1	0	0	0	0	1	0	0	0	11448	1203	42	4	22	4	PAH	12	103232972	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2633472	103232972	30618923	350	24386											
CUX2	23316	broad.mit.edu	37	chr12	111655724	111655724	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agatggtggctcctgtattaAaaagcttccaagccgaggta	12	10	11	8	1	0	1	0	0	0	1	2	2	2	1	3	3	2	4	3	3	6	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:111655724A>T	uc001tsa.1	+	3	358	c.205A>T	c.(205-207)AAA>TAA	p.K69*	CUX2_uc001tsb.1_Nonsense_Mutation_p.K124*	NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	69						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TCCTGTATTAAAAAGCTTCCA	0.567													28	84					0	0	0	0	T	111655724	T	T	111655724	4	4	136	1	0	0	0	0	0	1	0	0	4082	15	1	5	215	5	CUX2	12	111655724	Nonsense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	8422752	111655724	22196171	351	24387											
CUX2	23316	broad.mit.edu	37	chr12	111758214	111758214	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgctcagccgcccctacGcctccgtgtcgccctcgctg	2	8	10	21	5	1	0	1	0	0	0	4	0	2	0	7	0	3	2	7	0	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:111758214G>T	uc001tsa.1	+	17	2554	c.2401G>T	c.(2401-2403)GCC>TCC	p.A801S		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	801						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CCGCCCCTACGCCTCCGTGTC	0.721													20	55					6.21321e-17	8.8068e-17	1	0	T	111758214	T	T	111758214	3	4	136	1	0	0	0	0	1	0	0	0	4082	1087	38	3	2467	3	CUX2	12	111758214	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	102490	111758214	22093681	352	24388											
SRRM4	84530	broad.mit.edu	37	chr12	119583342	119583342	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtctcggggccaggagaagGggagccccagtgggggcttg	6	5	21	9	1	1	1	0	0	1	1	2	3	1	2	3	8	1	1	3	8	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:119583342G>A	uc001txa.1	+	9	1220	c.928G>A	c.(928-930)GGG>AGG	p.G310R		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	310	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CCAGGAGAAGGGGAGCCCCAG	0.622													4	28					0	0	0	0	A	119583342	A	A	119583342	3	1	136	1	0	0	0	0	1	0	0	0	15237	1232	43	4	962	4	SRRM4	12	119583342	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	7825128	119583342	14268553	353	24389											
SRRM4	84530	broad.mit.edu	37	chr12	119592088	119592088	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgagaaggactcgcagcagCgggagcgcgagcgagcgcgt	9	3	19	10	7	0	1	0	1	0	1	1	6	0	3	0	2	5	2	0	2	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:119592088C>A	uc001txa.1	+	12	1724	c.1432C>A	c.(1432-1434)CGG>AGG	p.R478R		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	478	Ser-rich.|Arg-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CTCGCAGCAGCGGGAGCGCGA	0.662													3	17					0.004672	0.00504772	1	0	A	119592088	A	A	119592088	2	1	136	1	0	0	0	0	0	0	0	1	15237	759	27	3		3	SRRM4	12	119592088	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	8746	119592088	14259807	354	24390											
VPS37B	79720	broad.mit.edu	37	chr12	123352007	123352007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggggggcagcggggccagggCctgtgggagtctctgcccct	3	6	20	12	1	1	0	0	0	1	0	2	1	1	1	4	7	2	1	4	7	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:123352007C>T	uc001udl.2	-	4	617	c.514G>A	c.(514-516)GCC>ACC	p.A172T		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	172	VPS37 C-terminal.|Pro-rich.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		GGGGCCAGGGCCTGTGGGAGT	0.642													35	110					0	0	0	0	T	123352007	T	T	123352007	3	4	136	1	0	0	0	0	1	0	0	0	17274	739	26	4	347	4	VPS37B	12	123352007	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3759919	123352007	10499888	355	24391											
NCOR2	9612	broad.mit.edu	37	chr12	124846676	124846676	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actggtgtgcactcaccctcCttgtcggcggggggtgccgg	3	9	16	13	3	1	0	1	0	0	0	3	0	2	0	3	6	2	1	3	6	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:124846676C>G	uc010tba.1	-	22	3213	c.3096G>C	c.(3094-3096)AAG>AAC	p.K1032N	NCOR2_uc010tay.1_Missense_Mutation_p.K1031N|NCOR2_uc010taz.1_Missense_Mutation_p.K1015N|NCOR2_uc010tbb.1_Missense_Mutation_p.K1032N|NCOR2_uc010tbc.1_Missense_Mutation_p.K1014N|NCOR2_uc001ugj.1_Missense_Mutation_p.K1032N	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1032					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		ACTCACCCTCCTTGTCGGCGG	0.652													5	11					0	0	0	0	G	124846676	G	G	124846676	3	3	136	1	0	0	0	0	1	0	0	0	10290	680	24	4	4576	4	NCOR2	12	124846676	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1494669	124846676	9005219	356	24392											
NCOR2	9612	broad.mit.edu	37	chr12	124862866	124862866	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctccaccacgggcgggaatGcagcctcctcgctggccgcc	5	5	12	19	4	0	0	0	0	0	0	3	1	2	1	7	3	2	2	7	3	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:124862866G>A	uc010tba.1	-	18	2201	c.2084C>T	c.(2083-2085)GCA>GTA	p.A695V	NCOR2_uc010tay.1_Missense_Mutation_p.A695V|NCOR2_uc010taz.1_Missense_Mutation_p.A695V|NCOR2_uc010tbb.1_Missense_Mutation_p.A695V|NCOR2_uc010tbc.1_Missense_Mutation_p.A694V|NCOR2_uc001ugj.1_Missense_Mutation_p.A695V	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	695					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGGCGGGAATGCAGCCTCCTC	0.667													12	39					0	0	0	0	A	124862866	A	A	124862866	3	1	136	1	0	0	0	0	1	0	0	0	10290	1319	46	4	5604	4	NCOR2	12	124862866	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	16190	124862866	8989029	357	24393											
TMEM132B	114795	broad.mit.edu	37	chr12	125834477	125834477	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagccagctgtcggctgcaaGgggccccagggctgtgtgtg	5	7	17	12	1	0	0	0	0	0	0	1	0	0	0	3	4	3	4	3	4	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr12:125834477G>T	uc001uhe.1	+	2	540	c.532G>T	c.(532-534)GGG>TGG	p.G178W		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	178	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TCGGCTGCAAGGGGCCCCAGG	0.622													28	79					8.58068e-18	1.23036e-17	1	0	T	125834477	T	T	125834477	3	4	136	1	0	0	0	0	1	0	0	0	16112	1000	35	4	538	4	TMEM132B	12	125834477	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	971611	125834477	8017418	358	24394											
RNF6	6049	broad.mit.edu	37	chr13	26789615	26789615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtttgttcgactcacagctCtccaagtttggttcccattt	6	16	8	11	1	2	0	1	0	1	0	5	1	3	0	2	2	1	5	2	2	1	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr13:26789615C>T	uc001uqo.2	-	5	695	c.404G>A	c.(403-405)AGA>AAA	p.R135K	RNF6_uc001uqn.1_Missense_Mutation_p.R135K|RNF6_uc010aak.2_Missense_Mutation_p.R135K|RNF6_uc001uqp.2_Missense_Mutation_p.R135K|RNF6_uc001uqq.2_Missense_Mutation_p.R135K|RNF6_uc010tdk.1_Missense_Mutation_p.E14K	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	135					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		ACTCACAGCTCTCCAAGTTTG	0.408													20	34					0	0	0	0	T	26789615	T	T	26789615	3	4	136	1	0	0	0	0	1	0	0	0	13563	913	32	2	1657	2	RNF6	13	26789615	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08		26789615	88380263	359	24395											
LNX2	222484	broad.mit.edu	37	chr13	28155627	28155627	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaaagtttctgaggcactTgtagcagaatgtatgtccac	13	12	9	7	0	1	2	0	1	1	1	2	2	2	2	1	1	1	5	1	1	6	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr13:28155627T>G	uc001url.3	-	2	523	c.214A>C	c.(214-216)AAG>CAG	p.K72Q	LNX2_uc001urm.1_Missense_Mutation_p.K72Q	NM_153371	NP_699202	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	72	RING-type.						zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	6		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CTGAGGCACTTGTAGCAGAAT	0.413													24	28					0	0	0	0	G	28155627	G	G	28155627	3	3	136	1	0	0	0	0	1	0	0	0	8908	1821	63	5	1894	5	LNX2	13	28155627	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	1366012	28155627	87014251	360	24396											
AKAP11	11215	broad.mit.edu	37	chr13	42874719	42874719	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cactaaaagaacgtgccattAgtggcctggctaactttttg	11	12	9	9	1	0	1	0	0	0	1	0	1	0	1	2	2	3	1	2	2	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr13:42874719A>G	uc001uys.1	+	8	2012	c.1837A>G	c.(1837-1839)AGT>GGT	p.S613G		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	613					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		ACGTGCCATTAGTGGCCTGGC	0.388													11	30					0	0	0	0	G	42874719	G	G	42874719	3	3	136	1	0	0	0	0	1	0	0	0	447	420	15	5	1859	5	AKAP11	13	42874719	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	14719092	42874719	72295159	361	24397											
PCDH8	5100	broad.mit.edu	37	chr13	53421350	53421351	+	Frame_Shift_Del	DEL	CG	-	-																															gaccagggccaccaggctctCgcgcgccgccccctccggca																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr13:53421350_53421351delCG	uc001vhi.2	-	1	1424_1425	c.1221_1222delCG	c.(1219-1224)CGCGAGfs	p.R407fs	PCDH8_uc001vhj.2_Frame_Shift_Del_p.R407fs	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	407_408	Extracellular (Potential).|Cadherin 4.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		ACCAGGCTCTCGCGCGCCGCCC	0.757													---	---	---								-	53421351	-	-	53421350	7	5	136	1	0	1	0	1	0	0	0	0	11571	893	31	0	2002	0	PCDH8	13	53421350	Frame_Shift_Del	DEL	CG	TCGA-CR-7364-01A-11D-2012-08	10546631	53421350	61748528	362	24398											
DIAPH3	81624	broad.mit.edu	37	chr13	60616954	60616954	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcggcttctcttaagacttcCctataaaataagtcaaaaaa	16	12	4	9	1	2	1	1	0	1	1	5	1	3	1	1	1	0	1	1	1	8	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr13:60616954C>T	uc001vht.2	-	5	715	c.496G>A	c.(496-498)GGA>AGA	p.G166R	DIAPH3_uc001vhw.1_Missense_Mutation_p.G155R|DIAPH3_uc010aed.1_Missense_Mutation_p.G120R|DIAPH3_uc010aee.1_Missense_Mutation_p.G96R|uc001vhx.2_Intron	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	166	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TTAAGACTTCCCTATAAAATA	0.378													8	21					0	0	0	0	T	60616954	T	T	60616954	3	4	136	1	0	0	0	0	1	0	0	0	4542	637	22	4	3201	4	DIAPH3	13	60616954	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	7195604	60616954	54552924	363	24399											
DACH1	1602	broad.mit.edu	37	chr13	72063214	72063214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aacctggaggcagtggttgtCcatgcccagttagagagagt	10	9	14	8	0	0	2	0	0	0	2	1	4	1	3	3	3	2	3	3	3	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr13:72063214C>T	uc010thn.1	-	8	2060	c.1637G>A	c.(1636-1638)GGA>GAA	p.G546E	DACH1_uc010tho.1_Missense_Mutation_p.G398E|DACH1_uc010thp.1_Missense_Mutation_p.G344E	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	598					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CAGTGGTTGTCCATGCCCAGT	0.448													55	104					0	0	0	0	T	72063214	T	T	72063214	3	4	136	1	0	0	0	0	1	0	0	0	4237	855	30	2	503	2	DACH1	13	72063214	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	11446260	72063214	43106664	364	24400											
MYCBP2	23077	broad.mit.edu	37	chr13	77672447	77672447	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtcatcgcaggtgctgtCtgttagactatttgttttta	6	18	10	7	1	2	1	1	0	1	1	3	1	2	1	0	1	1	5	0	1	3	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr13:77672447C>A	uc001vkf.2	-	57	8819	c.8728G>T	c.(8728-8730)GAC>TAC	p.D2910Y	MYCBP2_uc010aev.2_Missense_Mutation_p.D2314Y|MYCBP2_uc001vkg.1_Missense_Mutation_p.D433Y|MYCBP2_uc010aew.2_Missense_Mutation_p.D296Y	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2910					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CAGGTGCTGTCTGTTAGACTA	0.423													35	68					4.65686e-17	6.61596e-17	1	0	A	77672447	A	A	77672447	3	1	136	1	0	0	0	0	1	0	0	0	10071	913	32	2	5306	2	MYCBP2	13	77672447	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	5609233	77672447	37497431	365	24401											
SLITRK1	114798	broad.mit.edu	37	chr13	84453670	84453670	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagggaattaatctcggacGcggaggagttggcatctcgt	9	10	15	7	4	2	0	0	0	2	0	4	4	2	4	0	5	0	3	0	5	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr13:84453670G>T	uc001vlk.2	-	1	2859	c.1973C>A	c.(1972-1974)GCG>GAG	p.A658E		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	658	Cytoplasmic (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AATCTCGGACGCGGAGGAGTT	0.552													20	24					1.40151e-16	1.97747e-16	1	0	T	84453670	T	T	84453670	3	4	136	1	0	0	0	0	1	0	0	0	14806	1087	38	3	121	3	SLITRK1	13	84453670	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	6781223	84453670	30716208	366	24402											
SLC10A2	6555	broad.mit.edu	37	chr13	103701711	103701711	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaggtgaatacgacattgaGctcctcaggagtgaaggaga	14	7	14	6	1	1	4	1	3	0	1	2	8	2	5	1	3	2	1	1	3	4	2	rs144946104		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr13:103701711G>C	uc001vpy.3	-	5	1444	c.847C>G	c.(847-849)CTC>GTC	p.L283V		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	283	Extracellular (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ACGACATTGAGCTCCTCAGGA	0.473													34	21					0	0	0	0	C	103701711	C	C	103701711	3	2	136	1	0	0	0	0	1	0	0	0	14439	971	34	4	207	4	SLC10A2	13	103701711	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	19248041	103701711	11468167	367	24403											
CUL4A	8451	broad.mit.edu	37	chr13	113887572	113887572	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accattgatggaatcctactGctgatcgagcgcgagaggag	11	8	13	9	3	0	3	0	2	0	1	2	7	1	5	2	2	3	1	2	2	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr13:113887572G>A	uc010tjy.1	+	7	605	c.594G>A	c.(592-594)CTG>CTA	p.L198L	CUL4A_uc010tjx.1_Silent_p.L98L|CUL4A_uc010agu.2_Silent_p.L59L|CUL4A_uc001vtl.1_5'Flank	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	198					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			GAATCCTACTGCTGATCGAGC	0.512													43	38					0	0	0	0	A	113887572	A	A	113887572	2	1	136	1	0	0	0	0	0	0	0	1	4074	1306	46	4		4	CUL4A	13	113887572	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	10185861	113887572	1282306	368	24404											
POTEG	404785	broad.mit.edu	37	chr14	19563520	19563520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagacggccagagagtatgCtgtttctagtcatcataatg	12	11	10	8	1	3	2	2	0	1	2	3	3	3	2	1	1	1	3	1	1	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:19563520C>T	uc001vuz.1	+	5	1086	c.1034C>T	c.(1033-1035)GCT>GTT	p.A345V	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA|uc001vvb.2_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	345										ovary(1)	1						AGAGAGTATGCTGTTTCTAGT	0.353													45	161					0	0	0	0	T	19563520	T	T	19563520	3	4	136	1	0	0	0	0	1	0	0	0	12321	797	28	4	1052	4	POTEG	14	19563520	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08		19563520	87786020	369	24405											
OR10G2	26534	broad.mit.edu	37	chr14	22102184	22102184	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagccgctgccccatccaggGggtctttggagccagcccta	6	7	12	16	1	1	0	0	0	1	0	2	1	2	1	6	3	4	1	6	3	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:22102184G>T	uc010tmc.1	-	1	815	c.815C>A	c.(814-816)CCC>CAC	p.P272H		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		CCCATCCAGGGGGTCTTTGGA	0.542													22	62					2.37509e-13	3.21887e-13	1	0	T	22102184	T	T	22102184	3	4	136	1	0	0	0	0	1	0	0	0	10953	1232	43	4	120	4	OR10G2	14	22102184	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2538664	22102184	85247356	370	24406											
EFS	10278	broad.mit.edu	37	chr14	23826521	23826521	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaccatctcttggatggCagggctggatgggtagccca	7	9	14	11	0	1	0	0	0	1	0	2	2	1	2	2	5	2	4	2	5	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:23826521C>A	uc001wjo.2	-	6	2208	c.1600G>T	c.(1600-1602)GCC>TCC	p.A534S	EFS_uc001wjp.2_Missense_Mutation_p.A441S|EFS_uc010tnm.1_Missense_Mutation_p.A365S	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	534					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		TCTTGGATGGCAGGGCTGGAT	0.612													4	101					0.00909568	0.00977588	1	0	A	23826521	A	A	23826521	3	1	136	1	0	0	0	0	1	0	0	0	4981	710	25	4	89	4	EFS	14	23826521	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1724337	23826521	83523019	371	24407											
HEATR5A	25938	broad.mit.edu	37	chr14	31852842	31852842	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacttatgtccagtaagcCgttcaaggcaacgatccaag	14	8	9	10	2	1	1	1	0	0	1	3	2	3	1	3	1	2	3	3	1	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:31852842C>T	uc001wrf.3	-	4	679	c.602G>A	c.(601-603)CGG>CAG	p.R201Q	HEATR5A_uc010ami.2_Missense_Mutation_p.R99Q|HEATR5A_uc001wrg.1_Missense_Mutation_p.R83Q|HEATR5A_uc010tpk.1_Missense_Mutation_p.R494Q	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	488							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		TCCAGTAAGCCGTTCAAGGCA	0.473													55	113					0	0	0	0	T	31852842	T	T	31852842	3	4	136	1	0	0	0	0	1	0	0	0	7070	652	23	1	4767	1	HEATR5A	14	31852842	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	8026321	31852842	75496698	372	24408											
NPAS3	64067	broad.mit.edu	37	chr14	34269279	34269279	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggacagcgcaggcgaggCgggcgcgcaggcctccagca	7	2	17	15	6	0	0	0	0	0	0	2	2	1	1	2	5	2	3	2	5	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:34269279C>T	uc001wru.2	+	12	1830	c.1766C>T	c.(1765-1767)GCG>GTG	p.A589V	NPAS3_uc001wrs.2_Missense_Mutation_p.A576V|NPAS3_uc001wrt.2_Missense_Mutation_p.A557V|NPAS3_uc001wrv.2_Missense_Mutation_p.A559V	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	589					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GCAGGCGAGGCGGGCGCGCAG	0.687													5	17					0	0	0	0	T	34269279	T	T	34269279	3	4	136	1	0	0	0	0	1	0	0	0	10618	768	27	1	1867	1	NPAS3	14	34269279	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2416437	34269279	73080261	373	24409											
KCNH5	27133	broad.mit.edu	37	chr14	63453789	63453789	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaaattcatctcatacttaCttcagctagtcttgaatgtt	12	16	4	9	0	4	1	3	1	2	0	5	1	4	1	0	0	3	2	0	0	6	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:63453789C>A	uc001xfx.2	-	5	600	c.549_splice	c.e5+1	p.E183_splice	KCNH5_uc001xfy.2_Splice_Site_p.E183_splice|KCNH5_uc001xfz.1_Splice_Site_p.E125_splice|KCNH5_uc001xga.2_Splice_Site_p.E125_splice	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,						regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CTCATACTTACTTCAGCTAGT	0.378													27	66					7.68411e-24	1.15262e-23	1	0	A	63453789	A	A	63453789	5	1	136	1	0	0	0	0	0	0	1	0	8074	579	20	4	2478	4	KCNH5	14	63453789	Splice_Site	SNP	C	TCGA-CR-7364-01A-11D-2012-08	29184510	63453789	43895751	374	24410											
FNTB	2342	broad.mit.edu	37	chr14	65511158	65511158	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaccgcgcactgcacgccCaaggtgagcctggggagctg	7	5	14	15	3	0	1	0	1	0	0	1	2	1	2	4	3	3	3	4	3	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:65511158C>G	uc001xia.2	+	9	1117	c.952C>G	c.(952-954)CAA>GAA	p.Q318E	FNTB_uc010tsl.1_Missense_Mutation_p.Q352E|FNTB_uc010tsm.1_Missense_Mutation_p.Q272E|MAX_uc001xic.1_Intron|FNTB_uc001xid.2_Missense_Mutation_p.Q74E|FNTB_uc010tso.1_Missense_Mutation_p.Q233E	NM_002028	NP_002019	P49356	FNTB_HUMAN	farnesyltransferase, CAAX box, beta	318					protein farnesylation	microtubule associated complex	protein binding|protein farnesyltransferase activity			ovary(1)	1				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		ACTGCACGCCCAAGGTGAGCC	0.592													28	96					0	0	0	0	G	65511158	G	G	65511158	3	3	136	1	0	0	0	0	1	0	0	0	6010	595	21	4	986	4	FNTB	14	65511158	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2057369	65511158	41838382	375	24411											
SLC10A1	6554	broad.mit.edu	37	chr14	70263521	70263521	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacccccaggcctacctgaGgttcatgtcccccttcatgg	6	10	8	17	0	3	1	3	1	0	0	4	1	4	1	6	3	1	1	6	3	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:70263521G>A	uc001xlr.2	-	1	486	c.352C>T	c.(352-354)CTC>TTC	p.L118F		NM_003049	NP_003040	Q14973	NTCP_HUMAN	solute carrier family 10, member 1	118					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(1)	1				all cancers(60;0.00228)|BRCA - Breast invasive adenocarcinoma(234;0.0137)|OV - Ovarian serous cystadenocarcinoma(108;0.0226)		GCCTACCTGAGGTTCATGTCC	0.547													10	24					0	0	0	0	A	70263521	A	A	70263521	3	1	136	1	0	0	0	0	1	0	0	0	14438	1000	35	4	717	4	SLC10A1	14	70263521	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4752363	70263521	37086019	376	24412											
MED6	10001	broad.mit.edu	37	chr14	71058033	71058034	+	Missense_Mutation	DNP	CC	TA	TA																															gaggtctaaaagtaaagcatCcacacgttgtctctgaaaaa																								rs149635535		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:71058033_71058034CC>TA	uc001xmf.2	-	6	561_562	c.531_532GG>TA	c.(529-534)GTGGAT>GTTAAT	p.D178N	MED6_uc010tth.1_Missense_Mutation_p.D185N|MED6_uc010tti.1_Intron	NM_005466	NP_005457	O75586	MED6_HUMAN	mediator of RNA polymerase II transcription,	178					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	transcription coactivator activity				0				all cancers(60;0.00315)|BRCA - Breast invasive adenocarcinoma(234;0.00685)|OV - Ovarian serous cystadenocarcinoma(108;0.0352)		AGTAAAGCATCCACACGTTGTC	0.351													14	39					0	0	0	0	TA	71058034	TA	TA	71058033	3	4	136	1	0	0	0	0	1	0	0	0	9504	855	30	2	220	2	MED6	14	71058033	Missense_Mutation	DNP	CC	TCGA-CR-7364-01A-11D-2012-08	794512	71058033	36291507	377	24413											
FBLN5	10516	broad.mit.edu	37	chr14	92349360	92349360	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggcaggagcagaagtatgtgCcgggctggttcacacactca	10	7	14	10	1	2	1	2	0	0	1	2	2	2	2	1	4	2	5	1	4	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:92349360C>G	uc001xzx.3	-	8	1273	c.800G>C	c.(799-801)GGC>GCC	p.G267A	FBLN5_uc010aud.2_Missense_Mutation_p.G272A|FBLN5_uc010aue.2_Missense_Mutation_p.G308A	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	267	EGF-like 5; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				GAAGTATGTGCCGGGCTGGTT	0.567													23	74					0	0	0	0	G	92349360	G	G	92349360	3	3	136	1	0	0	0	0	1	0	0	0	5732	739	26	4	562	4	FBLN5	14	92349360	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	21291327	92349360	15000180	378	24414											
C14orf49	161176	broad.mit.edu	37	chr14	95942074	95942074	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccctgcgtgttgtcattgaCctgcagctggtcctgcacag	5	12	11	13	1	1	1	1	1	0	0	3	1	3	1	3	1	4	4	3	1	0	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:95942074C>G	uc001yei.3	-	1	100	c.85G>C	c.(85-87)GTC>CTC	p.V29L	C14orf49_uc010avi.2_Missense_Mutation_p.V29L|C14orf49_uc001yej.1_Missense_Mutation_p.V29L	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	29	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		TTGTCATTGACCTGCAGCTGG	0.652													5	16					0	0	0	0	G	95942074	G	G	95942074	3	3	136	1	0	0	0	0	1	0	0	0	1782	507	18	4	2910	4	C14orf49	14	95942074	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3592714	95942074	11407466	379	24415											
WDR25	79446	broad.mit.edu	37	chr14	100934422	100934422	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgcacacagaggcagtgcGggccgcccggtgggctccct	5	5	15	16	3	0	1	0	0	0	1	1	1	1	1	4	4	2	3	4	4	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:100934422G>C	uc010avx.2	+	3	980	c.887G>C	c.(886-888)CGG>CCG	p.R296P	WDR25_uc001yhm.2_Missense_Mutation_p.R288P|WDR25_uc001yhn.2_Missense_Mutation_p.R296P|WDR25_uc010avy.2_Intron|WDR25_uc001yho.2_Missense_Mutation_p.R39P	NM_001161476	NP_001154948	Q64LD2	WDR25_HUMAN	WD repeat domain 25	296	WD 2.										0		Melanoma(154;0.212)				GAGGCAGTGCGGGCCGCCCGG	0.617													37	125					0	0	0	0	C	100934422	C	C	100934422	3	2	136	1	0	0	0	0	1	0	0	0	17350	1116	39	3	893	3	WDR25	14	100934422	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4992348	100934422	6415118	380	24416											
KIF26A	26153	broad.mit.edu	37	chr14	104640109	104640109	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaggcggcggctggcagggCcggggaggctgctgggggtc	3	5	24	9	3	0	1	0	1	0	0	1	2	0	2	1	10	1	4	1	10	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:104640109C>T	uc001yos.3	+	10	1934	c.1934C>T	c.(1933-1935)GCC>GTC	p.A645V		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	645	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GCTGGCAGGGCCGGGGAGGCT	0.667													12	30					0	0	0	0	T	104640109	T	T	104640109	3	4	136	1	0	0	0	0	1	0	0	0	8333	739	26	4	1972	4	KIF26A	14	104640109	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3705687	104640109	2709431	381	24417											
MTA1	9112	broad.mit.edu	37	chr14	105920619	105920619	+	Frame_Shift_Del	DEL	G	-	-																															cgagtaggaaaccggtaccaGgcagacatcaccgacttgtt																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr14:105920619delG	uc001yqx.2	+	7	709	c.522delG	c.(520-522)CAGfs	p.Q174fs	MTA1_uc001yqy.2_RNA|MTA1_uc001yqz.1_Frame_Shift_Del_p.Q88fs|MTA1_uc001yra.1_Frame_Shift_Del_p.Q88fs	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	174	ELM2.				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		ACCGGTACCAGGCAGACATCA	0.542													---	---	---								-	105920619	-	-	105920619	7	5	136	1	0	1	0	1	0	0	0	0	9961	991	35	0	548	0	MTA1	14	105920619	Frame_Shift_Del	DEL	G	TCGA-CR-7364-01A-11D-2012-08	1280510	105920619	1428921	382	24418											
MAGEL2	54551	broad.mit.edu	37	chr15	23889144	23889144	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctctgctacacctattagCggggagggggcctgctggtg	6	10	15	10	1	1	0	0	0	1	0	2	1	1	1	2	5	4	2	2	5	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:23889144C>A	uc001ywj.3	-	1	2032	c.1937G>T	c.(1936-1938)CGC>CTC	p.R646L		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		CACCTATTAGCGGGGAGGGGG	0.582													3	27					0.004672	0.00504772	1	0	A	23889144	A	A	23889144	3	1	136	1	0	0	0	0	1	0	0	0	9242	768	27	3	7	3	MAGEL2	15	23889144	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08		23889144	78642248	383	24419											
TJP1	7082	broad.mit.edu	37	chr15	30003139	30003139	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaggagggggagtggccTggatgggttcatagcgtttc	7	9	20	5	1	1	0	1	0	0	0	2	5	1	4	1	7	1	2	1	7	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:30003139T>A	uc001zcr.2	-	24	4743	c.4268A>T	c.(4267-4269)CAG>CTG	p.Q1423L	TJP1_uc010azl.2_Missense_Mutation_p.Q1411L|TJP1_uc001zcq.2_Missense_Mutation_p.Q1347L|TJP1_uc001zcs.2_Missense_Mutation_p.Q1343L	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1423					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GGGAGTGGCCTGGATGGGTTC	0.522													74	163					0	0	0	0	A	30003139	A	A	30003139	3	1	136	1	0	0	0	0	1	0	0	0	15995	1580	55	5	998	5	TJP1	15	30003139	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	6113995	30003139	72528253	384	24420											
RYR3	6263	broad.mit.edu	37	chr15	34078040	34078040	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtcctactggtgggagcgggGtcctgagaacctgcccccca	6	7	14	14	1	0	1	0	1	0	1	2	3	2	2	6	4	4	0	6	4	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:34078040G>A	uc001zhi.2	+	66	9516	c.9446G>A	c.(9445-9447)GGT>GAT	p.G3149D	RYR3_uc010bar.2_Missense_Mutation_p.G3149D	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3149					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGGAGCGGGGTCCTGAGAAC	0.572													76	186					0	0	0	0	A	34078040	A	A	34078040	3	1	136	1	0	0	0	0	1	0	0	0	13835	1261	44	4	9708	4	RYR3	15	34078040	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4074901	34078040	68453352	385	24421											
MAPKBP1	23005	broad.mit.edu	37	chr15	42113133	42113133	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtggaactgagcgttagatCcatgctggatctgcggcagc	8	10	14	9	2	1	2	0	1	1	1	2	4	2	4	1	3	5	3	1	3	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:42113133C>T	uc001zok.3	+	24	2889	c.2603C>T	c.(2602-2604)TCC>TTC	p.S868F	MAPKBP1_uc001zoj.3_Missense_Mutation_p.S862F|MAPKBP1_uc010bcj.2_Missense_Mutation_p.S369F|MAPKBP1_uc010bci.2_Missense_Mutation_p.S862F|MAPKBP1_uc010udb.1_Missense_Mutation_p.S701F|MAPKBP1_uc010bck.2_Missense_Mutation_p.S79F|MAPKBP1_uc010bcl.2_Missense_Mutation_p.S369F	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	868										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		AGCGTTAGATCCATGCTGGAT	0.627													14	32					0	0	0	0	T	42113133	T	T	42113133	3	4	136	1	0	0	0	0	1	0	0	0	9345	855	30	2	2693	2	MAPKBP1	15	42113133	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	8035093	42113133	60418259	386	24422											
SPG11	80208	broad.mit.edu	37	chr15	44921518	44921518	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgaaaagtgtttgctttGgggttcagaataactttctc	9	17	9	6	0	3	2	1	1	2	1	4	2	3	2	0	2	2	3	0	2	4	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:44921518G>A	uc001ztx.2	-	9	1835	c.1804C>T	c.(1804-1806)CAA>TAA	p.Q602*	SPG11_uc010ueh.1_Nonsense_Mutation_p.Q602*|SPG11_uc010uei.1_Nonsense_Mutation_p.Q602*|SPG11_uc001zua.1_Nonsense_Mutation_p.Q602*	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	602	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TGTTTGCTTTGGGGTTCAGAA	0.358													16	44					0	0	0	0	A	44921518	A	A	44921518	4	1	136	1	0	0	0	0	0	1	0	0	15107	1357	47	4	5655	4	SPG11	15	44921518	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2808385	44921518	57609874	387	24423											
SQRDL	58472	broad.mit.edu	37	chr15	45965859	45965859	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaatagggtcgaattattcaGttaagactgtagagaagaca	17	10	10	4	1	1	3	1	0	0	3	2	5	1	3	0	1	0	2	0	1	7	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:45965859G>C	uc001zvt.2	+	6	703	c.514G>C	c.(514-516)GTT>CTT	p.V172L	SQRDL_uc001zvu.2_Missense_Mutation_p.V172L|SQRDL_uc001zvv.2_Missense_Mutation_p.V172L	NM_021199	NP_067022	Q9Y6N5	SQRD_HUMAN	sulfide dehydrogenase like precursor	172							oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		GAATTATTCAGTTAAGACTGT	0.418													45	93					0	0	0	0	C	45965859	C	C	45965859	3	2	136	1	0	0	0	0	1	0	0	0	15195	1029	36	4	528	4	SQRDL	15	45965859	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1044341	45965859	56565533	388	24424											
SLC24A5	283652	broad.mit.edu	37	chr15	48429025	48429025	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggagagaagtgaacaacagCcactgatgggctgggaagat	14	6	15	6	0	0	4	0	2	0	2	0	7	0	6	1	3	3	1	1	3	4	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:48429025C>T	uc001zwe.2	+	6	809	c.736C>T	c.(736-738)CCA>TCA	p.P246S	SLC24A5_uc010bel.2_Missense_Mutation_p.P186S|uc001zwf.1_5'Flank	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	246	Cytoplasmic (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		TGAACAACAGCCACTGATGGG	0.418													11	27					0	0	0	0	T	48429025	T	T	48429025	3	4	136	1	0	0	0	0	1	0	0	0	14533	739	26	4	758	4	SLC24A5	15	48429025	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2463166	48429025	54102367	389	24425											
UNC13C	440279	broad.mit.edu	37	chr15	54860126	54860126	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccttgataaagaaattcatAgatactcaaacctcacagag	17	9	6	9	0	3	4	3	1	0	3	3	4	3	4	2	0	2	0	2	0	6	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:54860126A>G	uc002ack.2	+	28	6087	c.6087A>G	c.(6085-6087)ATA>ATG	p.I2029M		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	2029					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGAAATTCATAGATACTCAAA	0.328													3	6					0	0	0	0	G	54860126	G	G	54860126	3	3	136	1	0	0	0	0	1	0	0	0	17054	410	15	5	6197	5	UNC13C	15	54860126	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	6431101	54860126	47671266	390	24426											
GCOM1	145781	broad.mit.edu	37	chr15	57953656	57953656	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttctttctagattgaatcAttaaagaaaaagttgcaaca	16	14	5	6	0	3	3	1	1	2	2	3	3	3	3	0	0	2	2	0	0	7	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:57953656A>G	uc002aei.2	+	11	1247	c.1128A>G	c.(1126-1128)TCA>TCG	p.S376S	GCOM1_uc002aej.2_Intron|GCOM1_uc002aek.2_Intron|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Silent_p.S376S|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_Intron|GCOM1_uc002aeo.2_Silent_p.S376S|GCOM1_uc002aep.2_Intron|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	376	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						AGATTGAATCATTAAAGAAAA	0.318													6	24					0	0	0	0	G	57953656	G	G	57953656	2	3	136	1	0	0	0	0	0	0	0	1	6340	204	8	5		5	GCOM1	15	57953656	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	3093530	57953656	44577736	391	24427											
VPS13C	54832	broad.mit.edu	37	chr15	62302756	62302756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgagctctgattctgcataaGgattcatgtagagttttgca	10	15	10	6	0	3	3	1	2	2	1	3	4	3	4	0	1	3	5	0	1	2	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:62302756G>A	uc002agz.2	-	13	1000	c.926C>T	c.(925-927)CCT>CTT	p.P309L	VPS13C_uc002aha.2_Missense_Mutation_p.P266L|VPS13C_uc002ahb.1_Missense_Mutation_p.P309L|VPS13C_uc002ahc.1_Missense_Mutation_p.P266L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	309					protein localization					ovary(2)	2						TTCTGCATAAGGATTCATGTA	0.373													22	65					0	0	0	0	A	62302756	A	A	62302756	3	1	136	1	0	0	0	0	1	0	0	0	17259	1000	35	4	10655	4	VPS13C	15	62302756	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4349100	62302756	40228636	392	24428											
KIAA0101	9768	broad.mit.edu	37	chr15	64673546	64673546	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttctgtaagtgcctggaaCactgtctgctttagtccgca	7	15	9	10	1	2	0	0	0	2	0	3	1	3	1	2	1	3	3	2	1	3	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:64673546C>T	uc002ank.2	-	1	157	c.25G>A	c.(25-27)GTT>ATT	p.V9I	KIAA0101_uc002anl.2_Missense_Mutation_p.V9I	NM_014736	NP_055551	Q15004	PAF_HUMAN	hypothetical protein LOC9768 isoform 1	9						mitochondrion|nucleus				central_nervous_system(1)	1						GTGCCTGGAACACTGTCTGCT	0.592													61	256					0	0	0	0	T	64673546	T	T	64673546	3	4	136	1	0	0	0	0	1	0	0	0	8194	478	17	4	351	4	KIAA0101	15	64673546	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2370790	64673546	37857846	393	24429											
ANKDD1A	348094	broad.mit.edu	37	chr15	65239631	65239631	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atctgccccacaggaccaccCcagtgatccctctgggaaga	10	6	9	16	0	2	2	0	1	2	1	3	4	3	4	6	2	1	0	6	2	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:65239631C>A	uc002aoa.2	+	13	1198	c.1169C>A	c.(1168-1170)CCC>CAC	p.P390H	ANKDD1A_uc002aoc.2_RNA|ANKDD1A_uc010bha.2_Missense_Mutation_p.P267H	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	390					signal transduction					ovary(1)	1						CAGGACCACCCCAGTGATCCC	0.607													8	26					0.00307968	0.00335078	1	0	A	65239631	A	A	65239631	3	1	136	1	0	0	0	0	1	0	0	0	624	623	22	4	1219	4	ANKDD1A	15	65239631	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	566085	65239631	37291761	394	24430											
IGDCC4	57722	broad.mit.edu	37	chr15	65676728	65676728	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctccacctggttcctgcaGgctgggggtgacttcttcct	3	12	12	14	0	1	1	0	1	1	0	4	1	4	1	5	4	1	3	5	4	0	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:65676728G>T	uc002aou.1	-	20	3582	c.3372C>A	c.(3370-3372)GCC>GCA	p.A1124A	IGDCC4_uc002aot.1_Silent_p.A712A	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	1124	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GGTTCCTGCAGGCTGGGGGTG	0.522													98	123					5.66435e-50	8.93002e-50	1	0	T	65676728	T	T	65676728	2	4	136	1	0	0	0	0	0	0	0	1	7608	987	35	4		4	IGDCC4	15	65676728	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	437097	65676728	36854664	395	24431											
SLC24A1	9187	broad.mit.edu	37	chr15	65916538	65916538	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atcggttctacttatcagcaCcttaggagaccccggggcct	8	10	10	13	2	2	1	1	0	1	1	3	2	2	1	4	4	2	2	4	4	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:65916538C>T	uc010ujf.1	+	2	407	c.120C>T	c.(118-120)CAC>CAT	p.H40H	SLC24A1_uc010ujd.1_Silent_p.H40H|SLC24A1_uc010uje.1_Silent_p.H40H|SLC24A1_uc010ujg.1_Silent_p.H40H|SLC24A1_uc010ujh.1_Silent_p.H40H	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	40	Extracellular (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						CTTATCAGCACCTTAGGAGAC	0.532													20	89					0	0	0	0	T	65916538	T	T	65916538	2	4	136	1	0	0	0	0	0	0	0	1	14529	506	18	4		4	SLC24A1	15	65916538	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	239810	65916538	36614854	396	24432											
TBC1D21	161514	broad.mit.edu	37	chr15	74178913	74178913	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctgcttctgcttccagcGtgccttcaagtccttcgatg	4	15	9	13	2	3	0	1	0	2	0	6	1	5	0	3	0	4	3	3	0	1	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:74178913G>T	uc002avz.2	+	8	820	c.737G>T	c.(736-738)CGT>CTT	p.R246L	TBC1D21_uc010ulc.1_Missense_Mutation_p.R210L	NM_153356	NP_699187	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	246	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(2)	2						TGCTTCCAGCGTGCCTTCAAG	0.592													33	58					3.21399e-22	4.77464e-22	1	0	T	74178913	T	T	74178913	3	4	136	1	0	0	0	0	1	0	0	0	15676	1145	40	3	767	3	TBC1D21	15	74178913	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	8262375	74178913	28352479	397	24433											
CSK	1445	broad.mit.edu	37	chr15	75090969	75090969	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttgcaggccgcctggccatCcggtacagaatgtattgcca	8	9	11	13	2	0	1	0	0	0	1	1	1	1	1	5	3	3	3	5	3	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:75090969C>T	uc010bkb.1	+	4	212	c.29C>T	c.(28-30)TCC>TTC	p.S10F	CSK_uc010bka.2_Silent_p.I80I|CSK_uc002ays.2_Missense_Mutation_p.S10F|CSK_uc010bkc.1_5'Flank	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	10	Interaction with PTPN8 (By similarity).|SH3.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						GCCTGGCCATCCGGTACAGAA	0.642													20	23					0	0	0	0	T	75090969	T	T	75090969	3	4	136	1	0	0	0	0	1	0	0	0	3960	855	30	2	35	2	CSK	15	75090969	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	912056	75090969	27440423	398	24434											
MAN2C1	4123	broad.mit.edu	37	chr15	75648457	75648457	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acaccgccactcacaggatgGcctcctgaaccggcagcgac	10	4	10	17	3	1	1	1	1	0	0	2	3	2	2	5	3	2	1	5	3	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:75648457G>C	uc002baf.2	-	25	3007	c.2990C>G	c.(2989-2991)GCC>GGC	p.A997G	MIR631_hsa-mir-631|MI0003645_5'Flank|MAN2C1_uc002bag.2_Missense_Mutation_p.A974G|MAN2C1_uc002bah.2_Missense_Mutation_p.A1014G|MAN2C1_uc010bkk.2_Missense_Mutation_p.A898G	NM_006715	NP_006706	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	997					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding				0						TCACAGGATGGCCTCCTGAAC	0.672													10	49					0	0	0	0	C	75648457	C	C	75648457	3	2	136	1	0	0	0	0	1	0	0	0	9271	1203	42	4	140	4	MAN2C1	15	75648457	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	557488	75648457	26882935	399	24435											
NRG4	145957	broad.mit.edu	37	chr15	76254225	76254225	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actaggaccgccaatgccacAaaagcttcaaacaggttact	15	7	7	12	1	1	0	1	0	0	0	1	1	1	1	3	2	4	2	3	2	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:76254225A>G	uc002bbo.2	-	4	379	c.195T>C	c.(193-195)TTT>TTC	p.F65F	NRG4_uc010bkm.1_RNA|NRG4_uc002bbn.2_RNA|NRG4_uc010bkn.2_RNA|NRG4_uc010bko.2_RNA|NRG4_uc002bbp.2_RNA	NM_138573	NP_612640	Q8WWG1	NRG4_HUMAN	neuregulin 4	65	Helical; Note=Internal signal sequence; (Potential).					extracellular region|integral to membrane|plasma membrane	growth factor activity				0						CCAATGCCACAAAAGCTTCAA	0.393													100	97					0	0	0	0	G	76254225	G	G	76254225	2	3	136	1	0	0	0	0	0	0	0	1	10704	127	5	5		5	NRG4	15	76254225	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	605768	76254225	26277167	400	24436											
AP3B2	8120	broad.mit.edu	37	chr15	83328416	83328417	+	Silent	DNP	GG	AT	AT																															tccagctggccgggcatccaGggtcagcagaacgaggcttc																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:83328416_83328417GG>AT	uc010uoh.1	-	26	3321_3322	c.3144_3145CC>AT	c.(3142-3147)ACCCTG>ACATTG	p.1048_1049TL>TL	AP3B2_uc010uoi.1_Silent_p.1067_1068TL>TL|AP3B2_uc010uoj.1_Silent_p.1016_1017TL>TL|AP3B2_uc010bmp.2_Silent_p.111_112TL>TL|AP3B2_uc010uog.1_Silent_p.684_685TL>TL	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	1048_1049					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			CGGGCATCCAGGGTCAGCAGAA	0.559													14	43					0	0	0	0	AT	83328417	AT	AT	83328416	2	1	136	1	0	0	0	0	0	0	0	1	745	991	35	4		4	AP3B2	15	83328416	Silent	DNP	GG	TCGA-CR-7364-01A-11D-2012-08	7074191	83328416	19202976	401	24437											
NMB	4828	broad.mit.edu	37	chr15	85200448	85200448	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctgaggctcacgcccagagCcttctttagcaggaggattc	8	9	12	12	1	2	2	1	1	1	1	3	4	2	4	2	3	2	3	2	3	1	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:85200448C>G	uc002bkz.2	-	2	708	c.289G>C	c.(289-291)GCT>CCT	p.A97P	WDR73_uc002bkw.2_5'Flank|WDR73_uc002bkx.2_5'Flank|WDR73_uc010upa.1_5'Flank|NMB_uc002bla.2_Missense_Mutation_p.A97P	NM_021077	NP_066563	P08949	NMB_HUMAN	neuromedin B isoform 1	97					cell-cell signaling|neuropeptide signaling pathway	extracellular region|soluble fraction	hormone activity				0				all cancers(203;3.5e-06)		ACGCCCAGAGCCTTCTTTAGC	0.652													13	19					0	0	0	0	G	85200448	G	G	85200448	3	3	136	1	0	0	0	0	1	0	0	0	10540	739	26	4	188	4	NMB	15	85200448	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1872032	85200448	17330944	402	24438											
SLC28A1	9154	broad.mit.edu	37	chr15	85488082	85488082	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagatttaccagtgctgcCgtgaggccttccagaggtga	8	11	13	9	1	0	4	0	3	0	2	1	5	1	4	4	2	3	1	4	2	1	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:85488082C>T	uc002blg.2	+	18	2060	c.1858C>T	c.(1858-1860)CGT>TGT	p.R620C	SLC28A1_uc010bnb.2_Missense_Mutation_p.R620C|SLC28A1_uc010upe.1_Missense_Mutation_p.R454C|SLC28A1_uc010upf.1_Missense_Mutation_p.R620C|SLC28A1_uc010upg.1_Intron	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	620					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCAGTGCTGCCGTGAGGCCTT	0.592													36	54					0	0	0	0	T	85488082	T	T	85488082	3	4	136	1	0	0	0	0	1	0	0	0	14595	652	23	1	1991	1	SLC28A1	15	85488082	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	287634	85488082	17043310	403	24439											
KLHL25	64410	broad.mit.edu	37	chr15	86312264	86312264	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgataagcttggtgcgctCgtctgccatgaggagggcct	7	10	14	10	2	1	2	0	2	1	0	2	3	1	3	2	3	3	2	2	3	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:86312264C>A	uc002bly.2	-	2	981	c.778G>T	c.(778-780)GAG>TAG	p.E260*		NM_022480	NP_071925	Q9H0H3	ENC2_HUMAN	BTB/POZ KELCH domain protein	260						cytoplasm				ovary(2)	2						TTGGTGCGCTCGTCTGCCATG	0.667													17	26					0.00074312	0.000817168	1	0	A	86312264	A	A	86312264	4	1	136	1	0	0	0	0	0	1	0	0	8419	893	31	3	995	3	KLHL25	15	86312264	Nonsense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	824182	86312264	16219128	404	24440											
NTRK3	4916	broad.mit.edu	37	chr15	88679705	88679705	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggatgcctacctggtgaGtgttgatggactgcagccca	8	9	13	11	0	0	2	0	2	0	0	0	4	0	4	4	3	4	2	4	3	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:88679705G>T	uc002bme.1	-	7	920	c.758C>A	c.(757-759)ACT>AAT	p.T253N	NTRK3_uc002bmh.2_Missense_Mutation_p.T253N|NTRK3_uc002bmf.1_Missense_Mutation_p.T253N|NTRK3_uc010upl.1_Missense_Mutation_p.T155N|NTRK3_uc010bnh.1_Missense_Mutation_p.T253N|NTRK3_uc002bmg.2_Missense_Mutation_p.T253N	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	253	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TACCTGGTGAGTGTTGATGGA	0.517			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			10	46					7.48243e-07	8.85851e-07	1	0	T	88679705	T	T	88679705	3	4	136	1	0	0	0	0	1	0	0	0	10762	1029	36	4	2075	4	NTRK3	15	88679705	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2367441	88679705	13851687	405	24441											
HAPLN3	145864	broad.mit.edu	37	chr15	89424727	89424727	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcctgccgcaggtgcacGcggccttggtagtccccaaa	6	9	12	14	3	0	0	0	0	0	0	2	0	2	0	5	3	2	3	5	3	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:89424727G>A	uc002bnc.2	-	3	482	c.354C>T	c.(352-354)CGC>CGT	p.R118R	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Silent_p.R180R	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	118	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					GCAGGTGCACGCGGCCTTGGT	0.627													12	135					0	0	0	0	A	89424727	A	A	89424727	2	1	136	1	0	0	0	0	0	0	0	1	6995	1074	38	1		1	HAPLN3	15	89424727	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	745022	89424727	13106665	406	24442											
TARSL2	123283	broad.mit.edu	37	chr15	102201966	102201966	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctatcattctttccactgatCccaaaatggctcgatgaatg	11	13	6	11	1	2	2	1	2	1	0	5	3	4	2	2	1	0	1	2	1	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr15:102201966C>G	uc002bxm.2	-	16	2076	c.2021G>C	c.(2020-2022)GGA>GCA	p.G674A	TARSL2_uc002bxl.2_Missense_Mutation_p.G219A|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	674					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTCCACTGATCCCAAAATGGC	0.303													7	41					0	0	0	0	G	102201966	G	G	102201966	3	3	136	1	0	0	0	0	1	0	0	0	15627	855	30	2	403	2	TARSL2	15	102201966	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	12777239	102201966	329426	407	24443											
CASKIN1	57524	broad.mit.edu	37	chr16	2235118	2235118	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actaccccacctaccttgacGccttcagagcccgcgtgtag	8	8	8	17	3	1	2	1	1	0	1	1	2	1	2	6	0	3	1	6	0	3	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr16:2235118G>T	uc010bsg.1	-	12	1265	c.1233C>A	c.(1231-1233)GGC>GGA	p.G411G		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	411	CASK-binding (By similarity).				signal transduction	cytoplasm				skin(2)	2						CTACCTTGACGCCTTCAGAGC	0.687													8	20					0.000157383	0.000175882	1	0	T	2235118	T	T	2235118	2	4	136	1	0	0	0	0	0	0	0	1	2678	1074	38	3		3	CASKIN1	16	2235118	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08		2235118	88119635	408	24444											
NUBP1	4682	broad.mit.edu	37	chr16	10861862	10861862	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgccccagattccccagccAcgttagcctacagaagtata	12	7	7	15	2	0	2	0	0	0	2	1	2	1	2	6	0	3	2	6	0	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr16:10861862A>T	uc002daa.1	+	10	900	c.877A>T	c.(877-879)ACG>TCG	p.T293S	FAM18A_uc010uyr.1_Intron|FAM18A_uc010uys.1_Intron|FAM18A_uc010uyt.1_Intron|FAM18A_uc010bun.2_Intron|FAM18A_uc010uyu.1_Intron|FAM18A_uc002dad.3_Intron|FAM18A_uc010buo.1_3'UTR|FAM18A_uc002daf.1_RNA|NUBP1_uc002dab.1_Missense_Mutation_p.T282S|FAM18A_uc002dae.1_3'UTR	NM_002484	NP_002475	P53384	NUBP1_HUMAN	nucleotide binding protein 1	293					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			ovary(1)|skin(1)	2						TTCCCCAGCCACGTTAGCCTA	0.438													40	31					0	0	0	0	T	10861862	T	T	10861862	3	4	136	1	0	0	0	0	1	0	0	0	10769	159	6	5	915	5	NUBP1	16	10861862	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	8626744	10861862	79492891	409	24445											
ACSM5	54988	broad.mit.edu	37	chr16	20430566	20430566	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagggactgtgatgattccGggtgtgactcagctgacaga	9	9	14	9	1	1	5	1	4	0	1	2	6	2	6	2	2	1	1	2	2	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr16:20430566G>T	uc002dhe.2	+	4	579	c.432G>T	c.(430-432)CCG>CCT	p.P144P	ACSM5_uc002dhd.1_Silent_p.P144P	NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	144					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TGATGATTCCGGGTGTGACTC	0.552													20	46					8.10497e-08	9.84062e-08	1	0	T	20430566	T	T	20430566	2	4	136	1	0	0	0	0	0	0	0	1	187	1103	39	3		3	ACSM5	16	20430566	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	9568704	20430566	69924187	410	24446											
TNRC6A	27327	broad.mit.edu	37	chr16	24816384	24816384	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacacagcagcacaaccccGgggcatgcagcagcctccag	13	2	10	16	1	0	0	0	0	0	0	1	0	1	0	4	2	7	5	4	2	2	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr16:24816384G>A	uc002dmm.2	+	14	4148	c.4034G>A	c.(4033-4035)CGG>CAG	p.R1345Q	TNRC6A_uc010bxs.2_Missense_Mutation_p.R1092Q|TNRC6A_uc002dmn.2_Missense_Mutation_p.R1043Q|TNRC6A_uc002dmo.2_Missense_Mutation_p.R984Q|TNRC6A_uc002dmp.2_5'UTR|TNRC6A_uc002dmq.2_Missense_Mutation_p.R12Q	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1345					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GCACAACCCCGGGGCATGCAG	0.473													63	58					0	0	0	0	A	24816384	A	A	24816384	3	1	136	1	0	0	0	0	1	0	0	0	16406	1116	39	1	4088	1	TNRC6A	16	24816384	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4385818	24816384	65538369	411	24447											
ZNF48	197407	broad.mit.edu	37	chr16	30408665	30408665	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaggtctagggagtgagAacgtgatttctcagccgaat	10	10	12	9	2	3	2	2	2	2	1	4	5	3	3	2	2	2	0	2	2	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr16:30408665A>T	uc002dya.1	+	2	153	c.94A>T	c.(94-96)AAC>TAC	p.N32Y	ZNF48_uc002dxz.1_5'UTR	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGGAGTGAGAACGTGATTTC	0.473													28	85					0	0	0	0	T	30408665	T	T	30408665	3	4	136	1	0	0	0	0	1	0	0	0	18001	246	9	5	100	5	ZNF48	16	30408665	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	5592281	30408665	59946088	412	24448											
NOD2	64127	broad.mit.edu	37	chr16	50745419	50745419	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccccagactcagcttccCaaggtctgggacccagtctt	7	8	8	18	0	3	1	1	0	2	1	4	2	4	2	5	2	1	1	5	2	1	2	rs147417132		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr16:50745419C>T	uc002egm.1	+	4	1702	c.1597C>T	c.(1597-1599)CAA>TAA	p.Q533*	NOD2_uc010cbk.1_Nonsense_Mutation_p.Q506*|NOD2_uc002egl.1_Nonsense_Mutation_p.Q311*|NOD2_uc010cbl.1_Nonsense_Mutation_p.Q311*|NOD2_uc010cbm.1_Nonsense_Mutation_p.Q311*|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	533	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CTCAGCTTCCCAAGGTCTGGG	0.617													30	39					0	0	0	0	T	50745419	T	T	50745419	4	4	136	1	0	0	0	0	0	1	0	0	10571	595	21	4	1611	4	NOD2	16	50745419	Nonsense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	20336754	50745419	39609334	413	24449											
ZFHX3	463	broad.mit.edu	37	chr16	72991344	72991344	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctagagcaggcgtcatggCggccatgggcccggcgggat	7	5	17	12	4	1	1	1	0	0	1	1	2	1	2	3	6	1	1	3	6	1	1	rs148024459	by1000genomes	TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr16:72991344C>G	uc002fck.2	-	2	3374	c.2701G>C	c.(2701-2703)GCC>CCC	p.A901P	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	901					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GGCGTCATGGCGGCCATGGGC	0.547													59	42					0	0	0	0	G	72991344	G	G	72991344	3	3	136	1	0	0	0	0	1	0	0	0	17701	768	27	3	8446	3	ZFHX3	16	72991344	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	22245925	72991344	17363409	414	24450											
FOXC2	2303	broad.mit.edu	37	chr16	86602395	86602395	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccctacagatccacgcCgcctctctatcgccacgcag	7	7	8	19	4	1	1	0	0	1	1	4	1	2	1	5	0	2	2	5	0	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr16:86602395C>A	uc002fjq.2	+	1	1539	c.1454C>A	c.(1453-1455)CCG>CAG	p.P485Q		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	485					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						AGATCCACGCCGCCTCTCTAT	0.647									Late-onset_Hereditary_Lymphedema				39	25					8.16277e-20	1.18696e-19	1	0	A	86602395	A	A	86602395	3	1	136	1	0	0	0	0	1	0	0	0	6027	652	23	3	1456	3	FOXC2	16	86602395	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	13611051	86602395	3752358	415	24451											
MYO1C	4641	broad.mit.edu	37	chr17	1381744	1381744	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagccataaatatccaggaGcccgagaaccgtggtgctcc	13	6	10	12	2	0	1	0	0	0	1	2	3	2	2	5	2	4	1	5	2	5	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:1381744G>A	uc002fsp.2	-	11	1475	c.1255C>T	c.(1255-1257)CTC>TTC	p.L419F	MYO1C_uc002fsn.2_Missense_Mutation_p.L400F|MYO1C_uc002fso.2_Missense_Mutation_p.L384F|MYO1C_uc010vqj.1_Missense_Mutation_p.L384F|MYO1C_uc010vqk.1_Missense_Mutation_p.L395F	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	419	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		ATATCCAGGAGCCCGAGAACC	0.622													25	45					0	0	0	0	A	1381744	A	A	1381744	3	1	136	1	0	0	0	0	1	0	0	0	10123	971	34	4	2024	4	MYO1C	17	1381744	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08		1381744	79813466	416	24452											
C17orf81	23587	broad.mit.edu	37	chr17	7160292	7160292	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agactgaggtgaccctgggcGgtaccatgggccaggcctcg	7	6	16	12	2	0	3	0	2	0	1	1	3	0	3	4	5	1	1	4	5	1	1	rs147755585		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:7160292G>T	uc002gfg.1	+	6	681	c.574G>T	c.(574-576)GGT>TGT	p.G192C	C17orf81_uc002gfj.2_Missense_Mutation_p.G192C|C17orf81_uc010cmb.2_Missense_Mutation_p.G192C|C17orf81_uc002gfh.1_Missense_Mutation_p.G192C|C17orf81_uc002gfi.1_Missense_Mutation_p.G192C|C17orf81_uc002gfl.1_Missense_Mutation_p.G192C	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						GACCCTGGGCGGTACCATGGG	0.617													15	21					6.31663e-08	7.6844e-08	1	0	T	7160292	T	T	7160292	3	4	136	1	0	0	0	0	1	0	0	0	1894	1116	39	3	592	3	C17orf81	17	7160292	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	5778548	7160292	74034918	417	24453											
TP53	7157	broad.mit.edu	37	chr17	7579433	7579433	+	Frame_Shift_Del	DEL	G	-	-																															gccaggagggggctggtgcaGgggccgccggtgtaggagct																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:7579433delG	uc002gim.2	-	4	448	c.254delC	c.(253-255)CCTfs	p.P85fs	TP53_uc002gig.1_Frame_Shift_Del_p.P85fs|TP53_uc002gih.2_Frame_Shift_Del_p.P85fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.P85fs|TP53_uc010cni.1_Frame_Shift_Del_p.P85fs|TP53_uc002gij.2_Frame_Shift_Del_p.P85fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.P46fs|TP53_uc010cnk.1_Frame_Shift_Del_p.P100fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	85	Interaction with WWOX.		P -> S (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.A76_S90del15(3)|p.G59fs*23(3)|p.P85S(2)|p.V73fs*9(1)|p.A86fs*59(1)|p.P85fs*63(1)|p.P85fs*58(1)|p.D48fs*55(1)|p.A86fs*32(1)|p.P85fs*59(1)|p.A79_A88del10(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.P85L(1)|p.A83fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCTGGTGCAGGGGCCGCCGG	0.622		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7579433	-	-	7579433	7	5	136	1	0	1	0	1	0	0	0	0	16448	1000	35	0	1048	0	TP53	17	7579433	Frame_Shift_Del	DEL	G	TCGA-CR-7364-01A-11D-2012-08	419141	7579433	73615777	418	24454											
MYH4	4622	broad.mit.edu	37	chr17	10355578	10355578	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcccgggagaggtcagagcGctgcttctctgctttggccc	4	10	13	14	2	2	2	1	0	1	2	4	3	3	2	2	3	3	3	2	3	0	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:10355578G>T	uc002gmn.2	-	27	3529	c.3418C>A	c.(3418-3420)CGC>AGC	p.R1140S	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1140	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AGGTCAGAGCGCTGCTTCTCT	0.582													48	72					2.46787e-29	3.77511e-29	1	0	T	10355578	T	T	10355578	3	4	136	1	0	0	0	0	1	0	0	0	10090	1087	38	3	2457	3	MYH4	17	10355578	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2776145	10355578	70839632	419	24455											
KIAA0100	9703	broad.mit.edu	37	chr17	26964893	26964893	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaacaagttcatgtcttcgaCcttcaagtccaccttccaca	12	11	4	14	1	3	0	2	0	1	0	6	1	5	0	4	0	1	1	4	0	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:26964893C>T	uc002hbu.2	-	14	1831	c.1732G>A	c.(1732-1734)GTC>ATC	p.V578I		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	578						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					ATGTCTTCGACCTTCAAGTCC	0.393													17	41					0	0	0	0	T	26964893	T	T	26964893	3	4	136	1	0	0	0	0	1	0	0	0	8193	507	18	4	5079	4	KIAA0100	17	26964893	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	16609315	26964893	54230317	420	24456											
ZNF207	7756	broad.mit.edu	37	chr17	30692368	30692368	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtatgcccccacctgttccAcgtcctggaattcctccaat	7	11	7	16	1	0	0	0	0	0	0	4	1	4	1	7	2	1	2	7	2	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:30692368A>T	uc002hhh.3	+	7	790	c.642A>T	c.(640-642)CCA>CCT	p.P214P	ZNF207_uc002hhj.3_Silent_p.P230P|ZNF207_uc002hhi.3_Silent_p.P230P|ZNF207_uc010csz.2_Silent_p.P233P|ZNF207_uc002hhk.1_Silent_p.P230P|ZNF207_uc002hhl.1_RNA	NM_003457	NP_003448	O43670	ZN207_HUMAN	zinc finger protein 207 isoform a	214						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			CACCTGTTCCACGTCCTGGAA	0.458													49	81					0	0	0	0	T	30692368	T	T	30692368	2	4	136	1	0	0	0	0	0	0	0	1	17832	146	6	5		5	ZNF207	17	30692368	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	3727475	30692368	50502842	421	24457											
CCL2	6347	broad.mit.edu	37	chr17	32582401	32582401	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccgcccttctgtgcctgctGctcatagcagccaccttcat	5	11	8	17	1	3	0	2	0	1	0	3	0	3	0	5	0	5	3	5	0	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:32582401G>T	uc002hhy.2	+	1	106	c.33G>T	c.(31-33)CTG>CTT	p.L11L		NM_002982	NP_002973	P13500	CCL2_HUMAN	small inducible cytokine A2 precursor	11					angiogenesis|anti-apoptosis|apoptotic cell clearance|astrocyte cell migration|cell adhesion|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|G-protein signaling, coupled to cyclic nucleotide second messenger|helper T cell extravasation|humoral immune response|inflammatory response|JAK-STAT cascade|macrophage chemotaxis|monocyte chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of T cell activation|viral genome replication	extracellular space	CCR2 chemokine receptor binding|chemokine activity|protein kinase activity|signal transducer activity			pancreas(1)	1	Breast(3;0.00224)	Ovarian(249;0.0694)|Breast(31;0.151)|Lung NSC(157;0.153)		UCEC - Uterine corpus endometrioid carcinoma (308;0.000241)|BRCA - Breast invasive adenocarcinoma(366;0.0103)	Atorvastatin(DB01076)|Danazol(DB01406)|Mimosine(DB01055)|Simvastatin(DB00641)	TGTGCCTGCTGCTCATAGCAG	0.537													7	45					2.0095e-06	2.34315e-06	1	0	T	32582401	T	T	32582401	2	4	136	1	0	0	0	0	0	0	0	1	2904	1306	46	4		4	CCL2	17	32582401	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1890033	32582401	48612809	422	24458											
GHDC	84514	broad.mit.edu	37	chr17	40344951	40344951	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaggcctccccaaggtcctgGtttgaggtcgggggcagtgg	5	8	18	10	1	0	1	0	1	0	0	3	2	2	1	4	7	0	2	4	7	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:40344951G>C	uc002hzd.2	-	3	844	c.360C>G	c.(358-360)AAC>AAG	p.N120K	GHDC_uc002hzg.1_Missense_Mutation_p.N120K|GHDC_uc010wgg.1_Intron|GHDC_uc002hze.3_Missense_Mutation_p.N120K|GHDC_uc002hzf.3_Missense_Mutation_p.N120K|GHDC_uc010cxz.2_RNA	NM_032484	NP_115873	Q8N2G8	GHDC_HUMAN	LGP1 homolog isoform 1	120						endoplasmic reticulum|nuclear envelope					0		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		CAAGGTCCTGGTTTGAGGTCG	0.592													44	120					0	0	0	0	C	40344951	C	C	40344951	3	2	136	1	0	0	0	0	1	0	0	0	6406	1252	44	4	1349	4	GHDC	17	40344951	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	7762550	40344951	40850259	423	24459											
STAT5B	6777	broad.mit.edu	37	chr17	40368065	40368065	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcattgtcccagagaacagtGgccgtcgcattgttgtcctg	7	11	12	11	2	0	1	0	0	0	1	3	2	2	1	3	1	1	3	3	1	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:40368065G>A	uc002hzh.2	-	12	1609	c.1440C>T	c.(1438-1440)GCC>GCT	p.A480A		NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	480					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	AGAGAACAGTGGCCGTCGCAT	0.522													12	18					0	0	0	0	A	40368065	A	A	40368065	2	1	136	1	0	0	0	0	0	0	0	1	15335	1335	47	4		4	STAT5B	17	40368065	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	23114	40368065	40827145	424	24460											
RUNDC3A	10900	broad.mit.edu	37	chr17	42390790	42390790	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaacatgatttccagggccGggcatggatccgggtggcac	8	8	15	10	2	0	2	0	2	0	0	2	3	2	3	3	5	1	2	3	5	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:42390790G>T	uc002igl.3	+	4	651	c.377G>T	c.(376-378)CGG>CTG	p.R126L	RUNDC3A_uc002igi.2_Missense_Mutation_p.R126L|RUNDC3A_uc002igj.2_Missense_Mutation_p.R121L|RUNDC3A_uc002igk.2_Missense_Mutation_p.R122L	NM_001144825	NP_001138297	Q59EK9	RUN3A_HUMAN	RUN domain containing 3A isoform 1	126	Interaction with RAP2A (By similarity).|RUN.				small GTPase mediated signal transduction		small GTPase regulator activity				0		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TTCCAGGGCCGGGCATGGATC	0.607													13	48					1.61879e-10	2.07986e-10	1	0	T	42390790	T	T	42390790	3	4	136	1	0	0	0	0	1	0	0	0	13809	1116	39	3	391	3	RUNDC3A	17	42390790	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2022725	42390790	38804420	425	24461											
MAPT	4137	broad.mit.edu	37	chr17	44061110	44061110	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcacacccaacgtgcagaagGagcaggcgcactcggaggag	12	3	14	12	3	1	1	1	0	0	1	2	4	1	4	1	4	3	3	1	4	2	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:44061110G>C	uc002ijr.3	+	6	1260	c.940G>C	c.(940-942)GAG>CAG	p.E314Q	MAPT_uc010dau.2_Missense_Mutation_p.E314Q|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	314					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CGTGCAGAAGGAGCAGGCGCA	0.647													20	67					0	0	0	0	C	44061110	C	C	44061110	3	2	136	1	0	0	0	0	1	0	0	0	9350	1175	41	2	958	2	MAPT	17	44061110	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1670320	44061110	37134100	426	24462											
CHAD	1101	broad.mit.edu	37	chr17	48545852	48545853	+	Missense_Mutation	DNP	TG	AT	AT																															gcagcacgcggatgtcgttaTgggacaggtacaagtagata																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:48545852_48545853TG>AT	uc010dbr.2	-	1	375_376	c.322_323CA>AT	c.(322-324)CAT>ATT	p.H108I	ACSF2_uc002iqu.2_Intron|ACSF2_uc010wml.1_Intron|ACSF2_uc010wmm.1_Intron|ACSF2_uc010wmn.1_Intron|ACSF2_uc010wmo.1_Intron|CHAD_uc010dbs.2_Missense_Mutation_p.H108I|ACSF2_uc010dbt.1_Intron	NM_001267	NP_001258	O15335	CHAD_HUMAN	chondroadherin precursor	108	LRR 2.				regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(2)|central_nervous_system(1)	3	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GATGTCGTTATGGGACAGGTAC	0.629													23	76					0	0	0	0	AT	48545853	AT	AT	48545852	3	1	136	1	0	0	0	0	1	0	0	0	3325	1464	51	5	768	5	CHAD	17	48545852	Missense_Mutation	DNP	TG	TCGA-CR-7364-01A-11D-2012-08	4484742	48545852	32649358	427	24463											
TRIM25	7706	broad.mit.edu	37	chr17	54990924	54990924	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acgggcggctgcagcgggtgGtcctggaaggcggggctgtc	4	6	21	10	4	0	0	0	0	0	0	2	1	1	1	1	8	2	3	1	8	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:54990924G>A	uc002iut.2	-	1	486	c.426C>T	c.(424-426)GAC>GAT	p.D142D	TRIM25_uc010dcj.2_5'UTR	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	142					innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					GCAGCGGGTGGTCCTGGAAGG	0.637													19	29					0	0	0	0	A	54990924	A	A	54990924	2	1	136	1	0	0	0	0	0	0	0	1	16566	1252	44	4		4	TRIM25	17	54990924	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	6445072	54990924	26204286	428	24464											
ACE	1636	broad.mit.edu	37	chr17	61566111	61566111	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccatcctccagttttaccCgaaatacgtggaactcatca	12	10	6	13	2	2	0	2	0	0	0	4	2	4	1	4	1	4	1	4	1	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:61566111C>A	uc002jau.1	+	16	2430	c.2408C>A	c.(2407-2409)CCG>CAG	p.P803Q	ACE_uc002jav.1_Missense_Mutation_p.P229Q|ACE_uc010ddv.1_Missense_Mutation_p.P30Q|ACE_uc010wpj.1_Missense_Mutation_p.P229Q|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.P113Q	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	803	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CAGTTTTACCCGAAATACGTG	0.552													11	58					0.000673444	0.000741869	1	0	A	61566111	A	A	61566111	3	1	136	1	0	0	0	0	1	0	0	0	136	652	23	3	2673	3	ACE	17	61566111	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	6575187	61566111	19629099	429	24465											
ERN1	2081	broad.mit.edu	37	chr17	62121439	62121439	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcgtggctgcacagctccAtggcccggtaggtgtgtgcg	4	10	15	12	3	1	0	0	0	1	0	3	0	2	0	2	4	3	4	2	4	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:62121439A>G	uc002jdz.2	-	22	2956	c.2843T>C	c.(2842-2844)ATG>ACG	p.M948T	uc002jdy.1_5'Flank	NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	948	Cytoplasmic (Potential).|KEN.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						GCACAGCTCCATGGCCCGGTA	0.662													41	104					0	0	0	0	G	62121439	G	G	62121439	3	3	136	1	0	0	0	0	1	0	0	0	5261	217	8	5	94	5	ERN1	17	62121439	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	555328	62121439	19073771	430	24466											
KPNA2	3838	broad.mit.edu	37	chr17	66040510	66040510	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtggaacagttgaacagaTtgtgtaccttgttcactgtg	9	14	12	6	0	1	2	1	1	0	1	1	3	1	3	1	2	3	3	1	2	3	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:66040510T>A	uc002jgk.2	+	9	1370	c.1238T>A	c.(1237-1239)ATT>AAT	p.I413N	KPNA2_uc002jgl.2_Missense_Mutation_p.I413N	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	413	ARM 9.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GTTGAACAGATTGTGTACCTT	0.388													61	184					0	0	0	0	A	66040510	A	A	66040510	3	1	136	1	0	0	0	0	1	0	0	0	8469	1493	52	5	1268	5	KPNA2	17	66040510	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	3919071	66040510	15154700	431	24467											
HGS	9146	broad.mit.edu	37	chr17	79662939	79662939	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcggggccgcagcatcaccAatgactcggccgtgctctca	7	7	12	15	4	2	1	2	1	1	0	4	1	2	1	3	3	3	3	3	3	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr17:79662939A>G	uc002kbg.2	+	15	1380	c.1303A>G	c.(1303-1305)AAT>GAT	p.N435D		NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	435	Interaction with SNX1 (By similarity).				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			CAGCATCACCAATGACTCGGC	0.622													15	46					0	0	0	0	G	79662939	G	G	79662939	3	3	136	1	0	0	0	0	1	0	0	0	7126	130	5	5	1361	5	HGS	17	79662939	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	13622429	79662939	1532271	432	24468											
DLGAP1	9229	broad.mit.edu	37	chr18	3879232	3879232	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcacggtgagcgtggaggaCcaggcgctcttcttcagcag	7	8	14	12	3	4	1	2	1	2	0	4	3	4	3	1	4	2	2	1	4	0	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:3879232C>G	uc002kmf.2	-	1	904	c.837G>C	c.(835-837)TGG>TGC	p.W279C	DLGAP1_uc010wyz.1_Missense_Mutation_p.W279C|DLGAP1_uc002kmk.2_Missense_Mutation_p.W279C|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	279					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GCGTGGAGGACCAGGCGCTCT	0.642													19	65					0	0	0	0	G	3879232	G	G	3879232	3	3	136	1	0	0	0	0	1	0	0	0	4581	508	18	4	2191	4	DLGAP1	18	3879232	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08		3879232	74198016	433	24469											
EPB41L3	23136	broad.mit.edu	37	chr18	5489138	5489138	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcctggggctcggcctcCtggtccggcttggattccga	2	10	14	15	3	0	0	0	0	0	0	5	2	4	1	6	6	0	2	6	6	0	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:5489138C>T	uc002kmt.1	-	2	131	c.45G>A	c.(43-45)CAG>CAA	p.Q15Q	EPB41L3_uc010wzh.1_Silent_p.Q15Q|EPB41L3_uc002kmu.1_Silent_p.Q15Q|EPB41L3_uc010dkq.1_5'UTR|EPB41L3_uc010dks.1_Silent_p.Q37Q|EPB41L3_uc002kmv.1_5'UTR	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	15					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GCTCGGCCTCCTGGTCCGGCT	0.498													21	75					0	0	0	0	T	5489138	T	T	5489138	2	4	136	1	0	0	0	0	0	0	0	1	5178	680	24	4		4	EPB41L3	18	5489138	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1609906	5489138	72588110	434	24470											
TMEM200C	645369	broad.mit.edu	37	chr18	5891714	5891714	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gacaccccctggagccctagGgtggctcctggaccggtttt	5	9	13	14	1	0	0	0	0	0	0	1	3	1	2	5	5	1	2	5	5	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:5891714G>T	uc002kmx.1	-	1	390	c.349C>A	c.(349-351)CCT>ACT	p.P117T		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	117						integral to membrane					0						GGAGCCCTAGGGTGGCTCCTG	0.706													19	81					6.33239e-15	8.71585e-15	1	0	T	5891714	T	T	5891714	3	4	136	1	0	0	0	0	1	0	0	0	16191	1232	43	4	1520	4	TMEM200C	18	5891714	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	402576	5891714	72185534	435	24471											
LAMA1	284217	broad.mit.edu	37	chr18	6955459	6955459	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagctgcatccaccacacaCtgttcctgtaagagacacac	13	7	7	14	0	0	2	0	0	0	2	2	3	2	2	3	0	2	4	3	0	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:6955459C>T	uc002knm.2	-	57	8194	c.8100G>A	c.(8098-8100)CAG>CAA	p.Q2700Q	LAMA1_uc002knk.2_Silent_p.Q30Q|LAMA1_uc002knl.2_Silent_p.Q153Q|LAMA1_uc010wzj.1_Silent_p.Q2176Q	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2700					axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCACCACACACTGTTCCTGTA	0.557													18	13					0	0	0	0	T	6955459	T	T	6955459	2	4	136	1	0	0	0	0	0	0	0	1	8645	564	20	4		4	LAMA1	18	6955459	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1063745	6955459	71121789	436	24472											
FAM38B	63895	broad.mit.edu	37	chr18	10696112	10696112	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgaagaacatccagaagtGaattccgaacacaagaatga	19	6	9	7	1	0	6	0	3	0	3	2	8	2	6	2	0	2	0	2	0	7	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:10696112G>C	uc002kor.3	-	5	822	c.682C>G	c.(682-684)CAC>GAC	p.H228D	FAM38B_uc002koq.2_Missense_Mutation_p.H126D	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2271	Helical; (Potential).					integral to membrane	ion channel activity			ovary(1)	1						ATCCAGAAGTGAATTCCGAAC	0.502													31	116					0	0	0	0	C	10696112	C	C	10696112	3	2	136	1	0	0	0	0	1	0	0	0	5587	1290	45	2	1487	2	FAM38B	18	10696112	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	3740653	10696112	67381136	437	24473											
GATA6	2627	broad.mit.edu	37	chr18	19761485	19761485	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accaccttatggcgcagaaaCgccgagggtgaacccgtgtg	10	6	13	12	4	0	2	0	1	0	1	0	3	0	2	4	2	2	1	4	2	3	1	rs143026087	byFrequency	TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:19761485C>T	uc002ktt.1	+	4	1639	c.1374C>T	c.(1372-1374)AAC>AAT	p.N458N	GATA6_uc002ktu.1_Silent_p.N458N	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	458	GATA-type 2.				blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			GGCGCAGAAACGCCGAGGGTG	0.473													4	70					0	0	0	0	T	19761485	T	T	19761485	2	4	136	1	0	0	0	0	0	0	0	1	6293	535	19	1		1	GATA6	18	19761485	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	9065373	19761485	58315763	438	24474											
KIAA1632	57724	broad.mit.edu	37	chr18	43496500	43496500	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgttgtgtgacaccctgaGggacaccgctgtccaagtgt	7	10	12	12	1	0	2	0	2	0	0	1	3	1	3	4	1	0	2	4	1	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:43496500G>A	uc002lbm.2	-	18	3387	c.3287C>T	c.(3286-3288)CCT>CTT	p.P1096L	KIAA1632_uc002lbo.1_Missense_Mutation_p.P1096L|KIAA1632_uc010xcq.1_5'UTR|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_5'UTR	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1096					autophagy						0						GACACCCTGAGGGACACCGCT	0.537													14	36					0	0	0	0	A	43496500	A	A	43496500	3	1	136	1	0	0	0	0	1	0	0	0	8288	1000	35	4	4560	4	KIAA1632	18	43496500	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	23735015	43496500	34580748	439	24475											
MBD1	4152	broad.mit.edu	37	chr18	47803478	47803478	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttgggggctggatagcaCaagatgccttgtttgaagtc	9	11	13	8	0	0	2	0	1	0	1	1	3	0	3	2	3	2	3	2	3	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:47803478C>G	uc010dow.1	-	3	644	c.207G>C	c.(205-207)TTG>TTC	p.L69F	MBD1_uc002lef.2_5'Flank|MBD1_uc002leg.2_Missense_Mutation_p.L69F|MBD1_uc010xdi.1_Missense_Mutation_p.L95F|MBD1_uc002leh.3_Missense_Mutation_p.L69F|MBD1_uc002len.2_Missense_Mutation_p.L69F|MBD1_uc002lei.3_Missense_Mutation_p.L69F|MBD1_uc002lej.3_Missense_Mutation_p.L69F|MBD1_uc002lek.3_Missense_Mutation_p.L69F|MBD1_uc002lel.3_Missense_Mutation_p.L69F|MBD1_uc002lem.3_Missense_Mutation_p.L69F|MBD1_uc010xdj.1_Missense_Mutation_p.L69F|MBD1_uc010xdk.1_Missense_Mutation_p.L69F|MBD1_uc010dox.1_Missense_Mutation_p.L69F|MBD1_uc002leo.2_Missense_Mutation_p.L69F	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	69	MBD.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CTGGATAGCACAAGATGCCTT	0.537													10	41					0	0	0	0	G	47803478	G	G	47803478	3	3	136	1	0	0	0	0	1	0	0	0	9395	477	17	4	1860	4	MBD1	18	47803478	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	4306978	47803478	30273770	440	24476											
ST8SIA3	51046	broad.mit.edu	37	chr18	55020099	55020099	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagaaactgcaaaatggccCgggtcgccagtgtgctgggg	9	7	16	9	2	0	1	0	1	0	1	1	2	0	1	2	4	3	2	2	4	3	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:55020099C>T	uc002lgn.2	+	1	379	c.22C>T	c.(22-24)CGG>TGG	p.R8W		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	8	Cytoplasmic (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CAAAATGGCCCGGGTCGCCAG	0.557													15	34					0	0	0	0	T	55020099	T	T	55020099	3	4	136	1	0	0	0	0	1	0	0	0	15299	643	23	1	24	1	ST8SIA3	18	55020099	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	7216621	55020099	23057149	441	24477											
MC4R	4160	broad.mit.edu	37	chr18	58039143	58039143	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catagaagatagtaaagtacCtgtccactgcaattgaaagc	16	9	8	8	0	0	3	0	1	0	2	1	3	1	3	2	0	3	3	2	0	8	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:58039143C>A	uc002lie.1	-	1	859	c.440G>T	c.(439-441)AGG>ATG	p.R147M		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	147	Cytoplasmic (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				AGTAAAGTACCTGTCCACTGC	0.433													13	49					5.50884e-06	6.32799e-06	1	0	A	58039143	A	A	58039143	3	1	136	1	0	0	0	0	1	0	0	0	9419	681	24	4	562	4	MC4R	18	58039143	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	3019044	58039143	20038105	442	24478											
NETO1	81832	broad.mit.edu	37	chr18	70526311	70526311	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcactgtcttggagcggcTgtaaagaagaaagattgtgt	12	11	13	5	1	1	3	0	0	1	3	1	4	1	4	0	2	2	3	0	2	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:70526311T>A	uc002lkw.2	-	4	505	c.221_splice	c.e4-1	p.A74_splice	NETO1_uc002lkx.1_Splice_Site_p.A73_splice|NETO1_uc002lky.1_Splice_Site_p.A74_splice|NETO1_uc002lkz.2_Splice_Site_p.A73_splice	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3						memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TTGGAGCGGCTGTAAAGAAGA	0.368													9	48					0	0	0	0	A	70526311	A	A	70526311	5	1	136	1	0	0	0	0	0	0	1	0	10393	1594	55	5	1419	5	NETO1	18	70526311	Splice_Site	SNP	T	TCGA-CR-7364-01A-11D-2012-08	12487168	70526311	7550937	443	24479											
ZNF407	55628	broad.mit.edu	37	chr18	72344576	72344576	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgtgcttgtacagactgtgGgcaagtagctacaaatagga	12	10	13	6	0	0	1	0	0	0	1	0	2	0	2	0	2	4	5	0	2	6	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr18:72344576G>T	uc002llw.2	+	1	1658	c.1601G>T	c.(1600-1602)GGG>GTG	p.G534V	ZNF407_uc010xfc.1_Missense_Mutation_p.G534V|ZNF407_uc010dqu.1_Missense_Mutation_p.G534V|ZNF407_uc002llu.2_Missense_Mutation_p.G533V	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	534	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		ACAGACTGTGGGCAAGTAGCT	0.517													71	183					4.60868e-44	7.24724e-44	1	0	T	72344576	T	T	72344576	3	4	136	1	0	0	0	0	1	0	0	0	17954	1232	43	4	1603	4	ZNF407	18	72344576	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1818265	72344576	5732672	444	24480											
SGTA	6449	broad.mit.edu	37	chr19	2757733	2757734	+	Missense_Mutation	DNP	CC	AA	AA																															cgttctgcgaggggctggtgCcgggagttcccaaggggttg																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:2757733_2757734CC>AA	uc002lwi.1	-	10	931_932	c.784_785GG>TT	c.(784-786)GGC>TTC	p.G262F		NM_003021	NP_003012	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide	262					interspecies interaction between organisms	cytoplasm	protein binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGCTGGTGCCGGGAGTTCCC	0.678													4	7					0	0	0	0	AA	2757734	AA	AA	2757733	3	1	136	1	0	0	0	0	1	0	0	0	14290	739	26	4	164	4	SGTA	19	2757733	Missense_Mutation	DNP	CC	TCGA-CR-7364-01A-11D-2012-08		2757733	56371250	445	24481											
CHAF1A	10036	broad.mit.edu	37	chr19	4442304	4442304	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaggaagaggaggagggCgactgtatgatcgtggatgt	11	7	20	3	2	0	2	0	1	0	1	1	9	0	7	0	6	0	1	0	6	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:4442304C>T	uc002mal.2	+	14	2836	c.2736C>T	c.(2734-2736)GGC>GGT	p.G912G		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	912	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		aggaggaggGCGACTGTATGA	0.517								Chromatin_Structure					7	13					0	0	0	0	T	4442304	T	T	4442304	2	4	136	1	0	0	0	0	0	0	0	1	3326	755	27	1		1	CHAF1A	19	4442304	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1684571	4442304	54686679	446	24482											
MLLT1	4298	broad.mit.edu	37	chr19	6230694	6230694	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttccaggttcaggaacaggtCgtaggtgaagcagaccttcc	10	9	12	10	1	1	2	1	1	0	1	4	3	3	3	3	4	2	3	3	4	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:6230694C>T	uc002mek.2	-	4	471	c.307G>A	c.(307-309)GAC>AAC	p.D103N		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	103	YEATS.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						AGGAACAGGTCGTAGGTGAAG	0.582			T	MLL	AL								46	99					0	0	0	0	T	6230694	T	T	6230694	3	4	136	1	0	0	0	0	1	0	0	0	9678	884	31	1	1408	1	MLLT1	19	6230694	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1788390	6230694	52898289	447	24483											
MUC16	94025	broad.mit.edu	37	chr19	8969277	8969277	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cataccacccccttctcaccGcatcctcaatattccttttg	8	13	2	18	1	2	0	2	0	1	0	5	0	4	0	6	0	1	1	6	0	3	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:8969277G>T	uc002mkp.2	-	79	43271	c.43067C>A	c.(43066-43068)GCG>GAG	p.A14356E	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.A1156E|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTTCTCACCGCATCCTCAAT	0.438													21	61					3.83957e-06	4.44355e-06	1	0	T	8969277	T	T	8969277	3	4	136	1	0	0	0	0	1	0	0	0	10026	1101	38	3	480	3	MUC16	19	8969277	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2738583	8969277	50159706	448	24484											
MUC16	94025	broad.mit.edu	37	chr19	9059669	9059669	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaacatttgtatctcctgtGgggtaggtgatacccattga	10	13	11	7	0	1	3	0	2	1	1	2	3	1	3	2	3	2	2	2	3	4	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:9059669G>T	uc002mkp.2	-	3	27981	c.27777C>A	c.(27775-27777)CCC>CCA	p.P9259P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9261	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TATCTCCTGTGGGGTAGGTGA	0.468													32	43					3.99451e-17	5.68803e-17	1	0	T	9059669	T	T	9059669	2	4	136	1	0	0	0	0	0	0	0	1	10026	1335	47	4		4	MUC16	19	9059669	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	90392	9059669	50069314	449	24485											
ZNF560	147741	broad.mit.edu	37	chr19	9578043	9578043	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatacgaagacaggcagaaGaggtaaatggtttcccacat	16	7	11	7	1	0	3	0	0	0	3	1	5	1	3	1	3	1	3	1	3	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:9578043G>A	uc002mlp.1	-	10	1790	c.1580C>T	c.(1579-1581)TCT>TTT	p.S527F	ZNF560_uc010dwr.1_Missense_Mutation_p.S421F	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	527	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						ACAGGCAGAAGAGGTAAATGG	0.398													36	35					0	0	0	0	A	9578043	A	A	9578043	3	1	136	1	0	0	0	0	1	0	0	0	18058	942	33	2	796	2	ZNF560	19	9578043	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	518374	9578043	49550940	450	24486											
PIK3R2	5296	broad.mit.edu	37	chr19	18278076	18278076	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcatgaacagcctcaagccgGacctcatgcagctgcgcaag	11	5	11	14	2	2	1	2	1	0	0	2	2	2	2	3	1	6	4	3	1	3	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:18278076G>T	uc002nia.1	+	13	2208	c.1696G>T	c.(1696-1698)GAC>TAC	p.D566Y	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	566					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						CCTCAAGCCGGACCTCATGCA	0.622													16	42					6.94344e-10	8.81119e-10	1	0	T	18278076	T	T	18278076	3	4	136	1	0	0	0	0	1	0	0	0	11974	1174	41	2	1742	2	PIK3R2	19	18278076	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	8700033	18278076	40850907	451	24487											
ZNF253	56242	broad.mit.edu	37	chr19	20002666	20002666	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaccttacagatgtgaaGaatgtggcaaagcttttaac	16	10	9	6	0	0	4	0	1	0	3	0	4	0	4	1	1	4	2	1	1	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:20002666G>T	uc002noj.2	+	4	702	c.610G>T	c.(610-612)GAA>TAA	p.E204*	ZNF253_uc002nok.2_Nonsense_Mutation_p.E128*|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	204	C2H2-type 2.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGATGTGAAGAATGTGGCAA	0.373													11	28					5.16669e-11	6.69395e-11	1	0	T	20002666	T	T	20002666	4	4	136	1	0	0	0	0	0	1	0	0	17864	943	33	2	624	2	ZNF253	19	20002666	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1724590	20002666	39126317	452	24488											
ZNF99	7652	broad.mit.edu	37	chr19	22940345	22940345	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgccacattcttcacatttaTagggtttctttccagtatga	9	17	6	9	0	3	1	1	1	2	0	4	1	4	1	2	1	1	2	2	1	3	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:22940345T>A	uc010xrh.1	-	5	2093	c.2093A>T	c.(2092-2094)TAT>TTT	p.Y698F		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTCACATTTATAGGGTTTCTT	0.353													14	30					0	0	0	0	A	22940345	A	A	22940345	3	1	136	1	0	0	0	0	1	0	0	0	18271	1406	49	5	1031	5	ZNF99	19	22940345	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	2937679	22940345	36188638	453	24489											
ZNF99	7652	broad.mit.edu	37	chr19	22940512	22940512	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaccacattcttcacatttGtagggtttctctccagtatg	8	17	6	10	0	3	0	1	0	2	0	5	0	4	0	2	1	1	3	2	1	3	7			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:22940512G>T	uc010xrh.1	-	5	1926	c.1926C>A	c.(1924-1926)TAC>TAA	p.Y642*		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CTTCACATTTGTAGGGTTTCT	0.378													5	34					5.9392e-07	7.07211e-07	1	0	T	22940512	T	T	22940512	4	4	136	1	0	0	0	0	0	1	0	0	18271	1372	48	4	1198	4	ZNF99	19	22940512	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	167	22940512	36188471	454	24490											
TIMM50	92609	broad.mit.edu	37	chr19	39976376	39976376	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttctcccagaccctctgcagGaaccgtactaccagccaccc	9	7	6	19	1	2	1	0	0	2	1	3	2	2	2	6	1	5	2	6	1	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:39976376G>T	uc002olu.1	+	6	863	c.730G>T	c.(730-732)GAA>TAA	p.E244*	TIMM50_uc002olt.1_RNA|TIMM50_uc002olv.1_5'UTR	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50	141	Mitochondrial intermembrane (Potential).				mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			ovary(1)	1	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCCTCTGCAGGAACCGTACTA	0.587													16	75					6.49762e-13	8.72941e-13	1	0	T	39976376	T	T	39976376	4	4	136	1	0	0	0	0	0	1	0	0	15979	1175	41	2	752	2	TIMM50	19	39976376	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	17035864	39976376	19152607	455	24491											
LGALS13	29124	broad.mit.edu	37	chr19	40095319	40095319	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaccaatccactcttttatGtgagtactccatggtccaat	11	13	5	12	0	1	1	0	1	1	0	4	1	4	1	4	1	1	1	4	1	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:40095319G>C	uc002omb.2	+	2	132	c.92_splice	c.e2+1	p.I31_splice		NM_013268	NP_037400	Q9UHV8	PP13_HUMAN	galectin-13						lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			ovary(1)	1	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			ACTCTTTTATGTGAGTACTCC	0.453													39	114					0	0	0	0	C	40095319	C	C	40095319	5	2	136	1	0	0	0	0	0	0	1	0	8780	1391	48	4	99	4	LGALS13	19	40095319	Splice_Site	SNP	G	TCGA-CR-7364-01A-11D-2012-08	118943	40095319	19033664	456	24492											
CLC	1178	broad.mit.edu	37	chr19	40222130	40222130	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcaaaggtgtaagaggattGgccattgaccattacctaca	13	10	10	8	0	1	2	1	1	0	1	1	3	1	3	3	3	2	1	3	3	4	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:40222130G>T	uc002omh.2	-	4	395	c.319C>A	c.(319-321)CAA>AAA	p.Q107K		NM_001828	NP_001819	Q05315	LPPL_HUMAN	Charcot-Leyden crystal protein	107	Galectin.				lipid catabolic process|multicellular organismal development		carboxylesterase activity|lysophospholipase activity|sugar binding				0	all_cancers(60;2.99e-06)|all_lung(34;4.7e-08)|Lung NSC(34;5.46e-08)|Ovarian(47;0.06)	Renal(1328;0.000147)|Hepatocellular(1079;0.0202)|Myeloproliferative disorder(2;0.0255)	Epithelial(26;6.43e-25)|OV - Ovarian serous cystadenocarcinoma(5;1.07e-24)|all cancers(26;8.38e-23)	GBM - Glioblastoma multiforme(1328;4.97e-06)|STAD - Stomach adenocarcinoma(1328;0.00655)		TAAGAGGATTGGCCATTGACC	0.413													40	154					4.07013e-28	6.1802e-28	1	0	T	40222130	T	T	40222130	3	4	136	1	0	0	0	0	1	0	0	0	3471	1357	47	4	113	4	CLC	19	40222130	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	126811	40222130	18906853	457	24493											
FCGBP	8857	broad.mit.edu	37	chr19	40357440	40357440	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaagatgtggacctggccCacagcctccgttttgccatg	9	9	11	12	1	0	2	0	0	0	2	1	3	1	3	5	2	2	1	5	2	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:40357440C>A	uc002omp.3	-	34	15881	c.15873G>T	c.(15871-15873)GTG>GTT	p.V5291V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5291	VWFD 13.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGACCTGGCCCACAGCCTCCG	0.547													21	71					1.2644e-06	1.47993e-06	1	0	A	40357440	A	A	40357440	2	1	136	1	0	0	0	0	0	0	0	1	5810	581	21	4		4	FCGBP	19	40357440	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	135310	40357440	18771543	458	24494											
CEACAM7	1087	broad.mit.edu	37	chr19	42187951	42187951	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatatctttgttctccacCggattgaagttgttgctggt	8	16	9	8	1	2	1	0	1	2	0	3	2	2	2	2	2	1	4	2	2	3	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:42187951C>A	uc002ori.1	-	3	473	c.471G>T	c.(469-471)CCG>CCT	p.P157P	CEACAM7_uc010ehx.2_Silent_p.P157P|CEACAM7_uc010ehy.1_Intron	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	157	Ig-like C2-type.					anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		TGTTCTCCACCGGATTGAAGT	0.522													43	114					1.15183e-24	1.73195e-24	1	0	A	42187951	A	A	42187951	2	1	136	1	0	0	0	0	0	0	0	1	3212	639	23	3		3	CEACAM7	19	42187951	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	1830511	42187951	16941032	459	24495											
ARHGEF1	9138	broad.mit.edu	37	chr19	42406968	42406968	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgcggtgccgccgcctgcAgctgaaggacatgatcccca	7	5	12	17	4	0	2	0	2	0	0	1	3	1	3	6	2	3	2	6	2	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:42406968A>T	uc002orx.2	+	18	1767	c.1658A>T	c.(1657-1659)CAG>CTG	p.Q553L	ARHGEF1_uc002ory.2_Missense_Mutation_p.Q520L|ARHGEF1_uc002orz.2_Missense_Mutation_p.Q391L|ARHGEF1_uc002osa.2_Missense_Mutation_p.Q568L|ARHGEF1_uc002osb.2_Missense_Mutation_p.Q535L|ARHGEF1_uc002osc.2_Missense_Mutation_p.Q307L|ARHGEF1_uc002osd.2_Missense_Mutation_p.Q212L|ARHGEF1_uc002ose.2_5'UTR	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	553	DH.				cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		CGCCGCCTGCAGCTGAAGGAC	0.652													23	60					0	0	0	0	T	42406968	T	T	42406968	3	4	136	1	0	0	0	0	1	0	0	0	893	188	7	5	1773	5	ARHGEF1	19	42406968	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	219017	42406968	16722015	460	24496											
PSG6	5675	broad.mit.edu	37	chr19	43529172	43529172	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gggcttcaatcatgacttggGcagtggtaggcaagttccag	9	10	14	8	0	2	1	2	1	0	0	3	1	3	1	1	4	0	5	1	4	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:43529172G>T	uc002ovh.1	-	2	208	c.119C>A	c.(118-120)GCC>GAC	p.A40D	PSG11_uc002ouw.2_Missense_Mutation_p.A40D|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.A40D|PSG11_uc002ovm.1_Missense_Mutation_p.A34D|PSG11_uc002ovn.1_Missense_Mutation_p.A40D|PSG11_uc002ovo.1_Intron|PSG11_uc002ovp.1_Intron			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	34					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				CATGACTTGGGCAGTGGTAGG	0.478													64	189					8.81991e-31	1.3559e-30	1	0	T	43529172	T	T	43529172	3	4	136	1	0	0	0	0	1	0	0	0	12721	1203	42	4		4	PSG6	19	43529172	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1122204	43529172	15599811	461	24497											
ZNF222	7673	broad.mit.edu	37	chr19	44536052	44536052	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcaagcaaatttgggaacaAattgcaagtgacttaaccag	16	9	9	7	0	0	1	0	1	0	0	0	2	0	2	1	1	5	3	1	1	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:44536052A>G	uc002oyc.2	+	4	408	c.225A>G	c.(223-225)CAA>CAG	p.Q75Q	ZNF284_uc010ejd.2_Intron|ZNF222_uc002oye.2_Silent_p.Q115Q|ZNF222_uc002oyd.2_Silent_p.Q21Q	NM_013360	NP_037492	Q9UK12	ZN222_HUMAN	zinc finger protein 222 isoform 2	75	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Prostate(69;0.0435)				TTTGGGAACAAATTGCAAGTG	0.403													21	54					0	0	0	0	G	44536052	G	G	44536052	2	3	136	1	0	0	0	0	0	0	0	1	17843	11	1	5		5	ZNF222	19	44536052	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	1006880	44536052	14592931	462	24498											
ZNF285	26974	broad.mit.edu	37	chr19	44890987	44890987	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtgtgaactctctgatGagtgtgaagaacagagctat	12	11	11	7	0	1	6	0	4	1	2	3	6	2	6	1	0	3	1	1	0	4	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:44890987G>T	uc002ozd.3	-	4	1507	c.1420C>A	c.(1420-1422)CAT>AAT	p.H474N	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.H481N	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	474	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						ACTCTCTGATGAGTGTGAAGA	0.398													30	75					7.26314e-15	9.9526e-15	1	0	T	44890987	T	T	44890987	3	4	136	1	0	0	0	0	1	0	0	0	17889	1290	45	2	356	2	ZNF285	19	44890987	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	354935	44890987	14237996	463	24499											
IGFL4	444882	broad.mit.edu	37	chr19	46543550	46543550	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagcagggccagaaggtgcaGctggagccgcagagccgggt	10	3	18	10	2	0	2	0	0	0	2	0	3	0	3	3	4	5	4	3	4	2	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:46543550G>T	uc002pdy.1	-	3	249	c.195C>A	c.(193-195)AGC>AGA	p.S65R		NM_001002923	NP_001002923	Q6B9Z1	IGFL4_HUMAN	IGF-like family member 4 precursor	65						extracellular region					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)		AGAAGGTGCAGCTGGAGCCGC	0.597													20	53					8.81451e-21	1.28779e-20	1	0	T	46543550	T	T	46543550	3	4	136	1	0	0	0	0	1	0	0	0	7628	962	34	4	187	4	IGFL4	19	46543550	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1652563	46543550	12585433	464	24500											
DHX34	9704	broad.mit.edu	37	chr19	47884120	47884120	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggctagaagtccagaacatGtatgtgggaccccagaccat	12	7	12	10	0	0	3	0	0	0	3	1	4	1	4	4	2	1	2	4	2	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:47884120G>T	uc010xyn.1	+	15	3371	c.3030G>T	c.(3028-3030)ATG>ATT	p.M1010I	DHX34_uc010xyo.1_Missense_Mutation_p.M139I	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	1010						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TCCAGAACATGTATGTGGGAC	0.463													17	67					3.57192e-18	5.15759e-18	1	0	T	47884120	T	T	47884120	3	4	136	1	0	0	0	0	1	0	0	0	4529	1377	48	4	3084	4	DHX34	19	47884120	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1340570	47884120	11244863	465	24501											
ZNF350	59348	broad.mit.edu	37	chr19	52468462	52468462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcttatgcttaaccagacacGacatatacgcaaacgctttc	13	11	5	12	3	1	1	0	0	1	1	2	2	1	1	1	0	4	3	1	0	5	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:52468462G>A	uc002pyd.2	-	5	1472	c.1244C>T	c.(1243-1245)TCG>TTG	p.S415L	uc002pyb.2_Intron|uc002pyc.2_Intron	NM_021632	NP_067645	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	415	C2H2-type 8.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(1)	1		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		AACCAGACACGACATATACGC	0.473													21	49					0	0	0	0	A	52468462	A	A	52468462	3	1	136	1	0	0	0	0	1	0	0	0	17930	1059	37	1	358	1	ZNF350	19	52468462	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	4584342	52468462	6660521	466	24502											
ZNF350	59348	broad.mit.edu	37	chr19	52468703	52468703	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtgaaatctctgatgtgCtatgagacacgtcttctgaa	10	14	10	7	1	3	4	0	4	3	1	4	5	3	4	0	0	1	1	0	0	3	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:52468703C>T	uc002pyd.2	-	5	1231	c.1003G>A	c.(1003-1005)GCA>ACA	p.A335T	uc002pyb.2_Intron|uc002pyc.2_Intron	NM_021632	NP_067645	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	335	C2H2-type 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(1)	1		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		CTCTGATGTGCTATGAGACAC	0.393													19	68					0	0	0	0	T	52468703	T	T	52468703	3	4	136	1	0	0	0	0	1	0	0	0	17930	797	28	4	599	4	ZNF350	19	52468703	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	241	52468703	6660280	467	24503											
TMC4	147798	broad.mit.edu	37	chr19	54668180	54668180	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccgcacctgcagctccacGgtgcaccccgtagcccagta	7	6	10	18	3	0	0	0	0	0	0	2	0	2	0	6	1	4	6	6	1	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:54668180G>A	uc010erf.2	-	7	1251	c.1119C>T	c.(1117-1119)ACC>ACT	p.T373T	TMC4_uc002qdn.2_Missense_Mutation_p.R64C|TMC4_uc002qdo.2_Silent_p.T367T	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	373	Cytoplasmic (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCAGCTCCACGGTGCACCCCG	0.632													55	134					0	0	0	0	A	54668180	A	A	54668180	2	1	136	1	0	0	0	0	0	0	0	1	16053	1103	39	1		1	TMC4	19	54668180	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	2199477	54668180	4460803	468	24504											
LAIR1	3903	broad.mit.edu	37	chr19	54867571	54867571	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggaaggctcaccgaggtgtCcgtctctctgtccttctcag	6	11	11	13	2	4	0	2	0	3	0	8	2	6	1	3	3	0	1	3	3	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:54867571C>A	uc002qfk.1	-	9	1019	c.709G>T	c.(709-711)GAC>TAC	p.D237Y	LAIR1_uc002qfl.1_Missense_Mutation_p.D220Y|LAIR1_uc002qfm.1_Missense_Mutation_p.D236Y|LAIR1_uc002qfn.1_Missense_Mutation_p.D219Y|LAIR1_uc010yex.1_Missense_Mutation_p.D230Y|LAIR1_uc002qfo.2_Missense_Mutation_p.D219Y	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like	237	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity			ovary(4)	4	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		ACCGAGGTGTCCGTCTCTCTG	0.323													24	81					7.4402e-23	1.11064e-22	1	0	A	54867571	A	A	54867571	3	1	136	1	0	0	0	0	1	0	0	0	8642	855	30	2	162	2	LAIR1	19	54867571	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	199391	54867571	4261412	469	24505											
LILRA2	11027	broad.mit.edu	37	chr19	55087020	55087020	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctggacatcctgatcacagGtgaggagcccagcgggttca	9	7	13	12	1	2	2	2	2	0	0	3	4	3	4	3	4	2	1	3	4	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:55087020G>T	uc002qgg.3	+	5	1041	c.952_splice	c.e5+1	p.G318_splice	LILRA2_uc010ern.2_Splice_Site_p.G318_splice|LILRA2_uc002qgf.2_Splice_Site_p.G318_splice|LILRA2_uc010yfe.1_Splice_Site_p.G318_splice|LILRA2_uc010yff.1_Splice_Site_p.G306_splice|LILRA2_uc010ero.2_Splice_Site_p.G306_splice|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,						defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CTGATCACAGGTGAGGAGCCC	0.657													19	67					4.35082e-09	5.45396e-09	1	0	T	55087020	T	T	55087020	5	4	136	1	0	0	0	0	0	0	1	0	8826	1275	44	4	971	4	LILRA2	19	55087020	Splice_Site	SNP	G	TCGA-CR-7364-01A-11D-2012-08	219449	55087020	4041963	470	24506											
LILRA1	11024	broad.mit.edu	37	chr19	55106733	55106733	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcacagccccgtacccatgGgtggtcccgggccatcttct	5	9	10	17	2	3	0	1	0	2	0	4	0	4	0	5	3	2	1	5	3	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:55106733G>T	uc002qgh.1	+	5	709	c.527G>T	c.(526-528)GGG>GTG	p.G176V	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.G176V	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	176	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CGTACCCATGGGTGGTCCCGG	0.562													43	165					1.47197e-15	2.04422e-15	1	0	T	55106733	T	T	55106733	3	4	136	1	0	0	0	0	1	0	0	0	8825	1232	43	4	541	4	LILRA1	19	55106733	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	19713	55106733	4022250	471	24507											
LILRB1	10859	broad.mit.edu	37	chr19	55143548	55143548	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctgaactcccagccccatgCccgtgggtcgtcccgcgcca	5	6	10	20	4	0	1	0	1	0	0	3	1	2	1	7	1	3	0	7	1	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:55143548C>G	uc002qgj.2	+	6	861	c.521C>G	c.(520-522)GCC>GGC	p.A174G	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.A174G|LILRB1_uc002qgk.2_Missense_Mutation_p.A174G|LILRB1_uc002qgm.2_Missense_Mutation_p.A174G|LILRB1_uc010erq.2_Missense_Mutation_p.A174G|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	174	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CAGCCCCATGCCCGTGGGTCG	0.572										HNSCC(37;0.09)			38	92					0	0	0	0	G	55143548	G	G	55143548	3	3	136	1	0	0	0	0	1	0	0	0	8831	739	26	4	535	4	LILRB1	19	55143548	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	36815	55143548	3985435	472	24508											
SUV420H2	84787	broad.mit.edu	37	chr19	55853662	55853662	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgggacctggaggctGcgtaccgggccctgacgctg	5	5	18	13	4	0	1	0	1	0	0	0	3	0	3	3	5	3	4	3	5	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:55853662G>C	uc002qkj.3	+	3	438	c.190G>C	c.(190-192)GCG>CCG	p.A64P	SUV420H2_uc010esx.1_Missense_Mutation_p.A64P|SUV420H2_uc002qkk.1_Missense_Mutation_p.A64P|SUV420H2_uc002qkl.2_Intron	NM_032701	NP_116090	Q86Y97	SV422_HUMAN	suppressor of variegation 4-20 homolog 2	64					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding				0	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CCTGGAGGCTGCGTACCGGGC	0.726													5	13					0	0	0	0	C	55853662	C	C	55853662	3	2	136	1	0	0	0	0	1	0	0	0	15481	1319	46	4	196	4	SUV420H2	19	55853662	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	710114	55853662	3275321	473	24509											
PEG3	5178	broad.mit.edu	37	chr19	57327872	57327872	+	Frame_Shift_Del	DEL	C	-	-																															ttccctctagtatggattttCtgatgttctttcagggatga																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:57327872delC	uc002qnu.2	-	7	2289	c.1938delG	c.(1936-1938)CAGfs	p.Q646fs	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Frame_Shift_Del_p.Q617fs|PEG3_uc002qnv.2_Frame_Shift_Del_p.Q646fs|PEG3_uc002qnw.2_Frame_Shift_Del_p.Q522fs|PEG3_uc002qnx.2_Frame_Shift_Del_p.Q520fs|PEG3_uc010etr.2_Frame_Shift_Del_p.Q646fs	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	646	C2H2-type 4.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TATGGATTTTCTGATGTTCTT	0.398													---	---	---								-	57327872	-	-	57327872	7	5	136	1	0	1	0	1	0	0	0	0	11774	912	32	0	2832	0	PEG3	19	57327872	Frame_Shift_Del	DEL	C	TCGA-CR-7364-01A-11D-2012-08	1474210	57327872	1801111	474	24510											
ZNF135	7694	broad.mit.edu	37	chr19	58578900	58578900	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcatctgcgaatccacactGgggagaaaccctatcagtgt	12	8	10	11	1	2	1	1	0	1	1	3	3	3	1	2	2	3	1	2	2	3	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr19:58578900G>A	uc010yhq.1	+	5	1180	c.1084G>A	c.(1084-1086)GGG>AGG	p.G362R	ZNF135_uc002qre.2_Missense_Mutation_p.G350R|ZNF135_uc002qrd.1_Missense_Mutation_p.G308R|ZNF135_uc002qrf.2_Missense_Mutation_p.G308R|ZNF135_uc002qrg.2_Missense_Mutation_p.G320R|ZNF135_uc010yhr.1_Missense_Mutation_p.G171R	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	362					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		AATCCACACTGGGGAGAAACC	0.572													18	32					0	0	0	0	A	58578900	A	A	58578900	3	1	136	1	0	0	0	0	1	0	0	0	17792	1348	47	4	1251	4	ZNF135	19	58578900	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1251028	58578900	550083	475	24511											
ProSAPiP1	9762	broad.mit.edu	37	chr20	3147647	3147647	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accccctgtgcgggtacccaCgctcttcatggcaaactcct	7	9	8	17	2	2	0	1	0	1	0	3	0	3	0	4	2	3	3	4	2	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr20:3147647C>A	uc002wia.1	-	1	1561	c.163G>T	c.(163-165)GTG>TTG	p.V55L	ProSAPiP1_uc002wib.1_Missense_Mutation_p.V55L	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	55						cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						CGGGTACCCACGCTCTTCATG	0.736													11	12					1.58986e-06	1.85735e-06	1	0	A	3147647	A	A	3147647	3	1	136	1	0	0	0	0	1	0	0	0	12935	536	19	3	1870	3	ProSAPiP1	20	3147647	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08		3147647	59877873	476	24512											
TPX2	22974	broad.mit.edu	37	chr20	30363782	30363782	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aattcaagaaacttgctctgGctggaataggtgagcttggc	11	11	12	7	0	2	2	1	1	1	1	2	3	2	3	0	4	3	3	0	4	5	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr20:30363782G>A	uc002wwp.1	+	8	1419	c.721G>A	c.(721-723)GCT>ACT	p.A241T	TPX2_uc010gdv.1_Missense_Mutation_p.A241T	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	241					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			ACTTGCTCTGGCTGGAATAGG	0.388													33	42					0	0	0	0	A	30363782	A	A	30363782	3	1	136	1	0	0	0	0	1	0	0	0	16499	1203	42	4	743	4	TPX2	20	30363782	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	27216135	30363782	32661738	477	24513											
GHRH	2691	broad.mit.edu	37	chr20	35885221	35885221	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgcttacctgagggtcaaAgggggaggtggggagcagtg	8	8	19	6	0	2	1	1	1	1	0	2	3	2	3	1	6	3	2	1	6	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr20:35885221A>T	uc002xgr.2	-	1	72	c.72T>A	c.(70-72)CCT>CCA	p.P24P	GHRH_uc002xgs.2_Silent_p.P24P|GHRH_uc002xgt.2_Silent_p.P24P	NM_021081	NP_066567	P01286	SLIB_HUMAN	growth hormone releasing hormone preproprotein	24					activation of adenylate cyclase activity by G-protein signaling pathway|adenohypophysis development|growth hormone secretion|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of circadian sleep/wake cycle, REM sleep|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to food	extracellular space|terminal button	growth hormone-releasing hormone activity|growth hormone-releasing hormone receptor binding			ovary(1)	1		Myeloproliferative disorder(115;0.00878)				TGAGGGTCAAAGGGGGAGGTG	0.602													10	36					0	0	0	0	T	35885221	T	T	35885221	2	4	136	1	0	0	0	0	0	0	0	1	6409	59	3	5		5	GHRH	20	35885221	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	5521439	35885221	27140299	478	24514											
MAFB	9935	broad.mit.edu	37	chr20	39316726	39316726	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctggacgcgtttatacctGcaagactgggcgtagccccg	7	9	13	12	4	0	1	0	0	0	1	0	2	0	2	3	2	4	4	3	2	4	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr20:39316726G>C	uc002xji.2	-	1	1151	c.765C>G	c.(763-765)TGC>TGG	p.C255W		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	255	Basic motif.				negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				GTTTATACCTGCAAGACTGGG	0.622			T	IGH@	MM								31	31					0	0	0	0	C	39316726	C	C	39316726	3	2	136	1	0	0	0	0	1	0	0	0	9209	1311	46	4	210	4	MAFB	20	39316726	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	3431505	39316726	23708794	479	24515											
PTPRT	11122	broad.mit.edu	37	chr20	40735527	40735527	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtcaagcatggtgtcaaTggcaatgaagcagccagtcc	12	8	11	10	0	2	1	2	1	0	0	3	1	3	1	2	2	3	3	2	2	4	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr20:40735527T>C	uc002xkg.2	-	24	3473	c.3289A>G	c.(3289-3291)ATT>GTT	p.I1097V	PTPRT_uc010ggj.2_Missense_Mutation_p.I1116V|PTPRT_uc010ggi.2_Missense_Mutation_p.I300V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1097	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATGGTGTCAATGGCAATGAAG	0.582													53	34					0	0	0	0	C	40735527	C	C	40735527	3	2	136	1	0	0	0	0	1	0	0	0	12877	1464	51	5	1068	5	PTPRT	20	40735527	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	1418801	40735527	22289993	480	24516											
ADA	100	broad.mit.edu	37	chr20	43251265	43251265	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgtgtccggcttccaggcaCcagtgaggtagctggaccag	7	7	14	13	2	0	1	0	1	0	0	2	2	2	2	5	4	1	4	5	4	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr20:43251265C>A	uc002xmj.2	-	9	937	c.809G>T	c.(808-810)GGT>GTT	p.G270V	ADA_uc010ggt.2_Intron	NM_000022	NP_000013	P00813	ADA_HUMAN	adenosine deaminase	270					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			pancreas(2)|ovary(1)	3		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	CTTCCAGGCACCAGTGAGGTA	0.592									Adenosine_Deaminase_Deficiency				20	14					4.35082e-09	5.45396e-09	1	0	A	43251265	A	A	43251265	3	1	136	1	0	0	0	0	1	0	0	0	230	507	18	4	298	4	ADA	20	43251265	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2515738	43251265	19774255	481	24517											
NEURL2	140825	broad.mit.edu	37	chr20	44519214	44519214	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatggttccacgaggagggtTggaggtcggctgggggccgc	5	8	20	8	3	0	0	0	0	0	0	2	3	1	2	2	8	0	3	2	8	1	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr20:44519214T>C	uc002xqg.1	-	1	688	c.417A>G	c.(415-417)CCA>CCG	p.P139P	C20orf165_uc002xqf.2_5'Flank|CTSA_uc002xqh.2_5'Flank|CTSA_uc002xqj.3_5'Flank|CTSA_uc002xqi.2_5'Flank|CTSA_uc010zxi.1_5'Flank|CTSA_uc002xqk.3_5'Flank	NM_080749	NP_542787	Q9BR09	NEUL2_HUMAN	neuralized-like protein 2	139	NHR.				intracellular signal transduction						0		Myeloproliferative disorder(115;0.0122)				CGAGGAGGGTTGGAGGTCGGC	0.701													28	20					0	0	0	0	C	44519214	C	C	44519214	2	2	136	1	0	0	0	0	0	0	0	1	10400	1799	63	5		5	NEURL2	20	44519214	Silent	SNP	T	TCGA-CR-7364-01A-11D-2012-08	1267949	44519214	18506306	482	24518											
SLC12A5	57468	broad.mit.edu	37	chr20	44685832	44685832	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtccaacgtgcggcgcaTgcacacggccgtgcggctga	7	5	14	15	6	0	1	0	1	0	0	1	1	1	1	3	3	4	3	3	3	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr20:44685832T>A	uc010zxl.1	+	25	3294	c.3218T>A	c.(3217-3219)ATG>AAG	p.M1073K	SLC12A5_uc002xrb.2_Missense_Mutation_p.M1050K	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	1073	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GTGCGGCGCATGCACACGGCC	0.637													50	39					0	0	0	0	A	44685832	A	A	44685832	3	1	136	1	0	0	0	0	1	0	0	0	14451	1464	51	5	3372	5	SLC12A5	20	44685832	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	166618	44685832	18339688	483	24519											
DOK5	55816	broad.mit.edu	37	chr20	53260098	53260098	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacggcagcacagcacgggAcagctctaccgcttgcaagg	11	4	12	14	3	1	0	0	0	1	0	1	1	1	1	1	3	5	6	1	3	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr20:53260098A>G	uc002xwy.2	+	7	1057	c.837A>G	c.(835-837)GGA>GGG	p.G279G	DOK5_uc010gin.2_Silent_p.G171G|DOK5_uc002xwz.2_Silent_p.G141G	NM_018431	NP_060901	Q9P104	DOK5_HUMAN	docking protein 5	279							insulin receptor binding			ovary(1)	1			Colorectal(105;0.202)			ACAGCACGGGACAGCTCTACC	0.652													10	45					0	0	0	0	G	53260098	G	G	53260098	2	3	136	1	0	0	0	0	0	0	0	1	4722	262	10	5		5	DOK5	20	53260098	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08	8574266	53260098	9765422	484	24520											
NCAM2	4685	broad.mit.edu	37	chr21	22746287	22746287	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatatgactgtgaagctgcAagcagaattggagggcatca	14	8	13	6	0	1	4	1	2	0	2	1	5	1	5	0	2	3	4	0	2	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr21:22746287A>C	uc002yld.1	+	9	1398	c.1149A>C	c.(1147-1149)GCA>GCC	p.A383A	NCAM2_uc011acb.1_Silent_p.A241A|NCAM2_uc011acc.1_Silent_p.A408A	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	383	Ig-like C2-type 4.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GTGAAGCTGCAAGCAGAATTG	0.393													12	43					0	0	0	0	C	22746287	C	C	22746287	2	2	136	1	0	0	0	0	0	0	0	1	10257	117	5	5		5	NCAM2	21	22746287	Silent	SNP	A	TCGA-CR-7364-01A-11D-2012-08		22746287	25383608	485	24521											
SON	6651	broad.mit.edu	37	chr21	34923211	34923211	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagtggcaacgacagcgctGgagttgccggggcagccttc	7	6	15	13	3	0	0	0	0	0	0	1	2	0	1	3	4	4	4	3	4	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr21:34923211G>T	uc002yse.1	+	3	1723	c.1674G>T	c.(1672-1674)CTG>CTT	p.L558L	SON_uc002ysb.1_Silent_p.L558L|SON_uc002ysc.2_Silent_p.L558L|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	558					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						CGACAGCGCTGGAGTTGCCGG	0.647													25	82					2.21704e-12	2.94019e-12	1	0	T	34923211	T	T	34923211	2	4	136	1	0	0	0	0	0	0	0	1	14990	1335	47	4		4	SON	21	34923211	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	12176924	34923211	13206684	486	24522											
DSCAM	1826	broad.mit.edu	37	chr21	41450794	41450794	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaaagggcctgtactctaGtgtgaaggaggtgatggggc	9	8	16	8	0	1	2	0	2	1	0	1	3	1	3	2	5	1	1	2	5	4	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr21:41450794G>T	uc002yyq.1	-	26	4983	c.4531C>A	c.(4531-4533)CTA>ATA	p.L1511I	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1511	Extracellular (Potential).|Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTGTACTCTAGTGTGAAGGAG	0.557													8	28					0.000157383	0.000175882	1	0	T	41450794	T	T	41450794	3	4	136	1	0	0	0	0	1	0	0	0	4790	1020	36	4	1539	4	DSCAM	21	41450794	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	6527583	41450794	6679101	487	24523											
FTCD	10841	broad.mit.edu	37	chr21	47557204	47557204	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaggttgatgagcacgttGaaatatgcgccaaacacgcc	12	8	10	11	3	1	3	1	3	0	0	1	3	1	3	2	1	3	3	2	1	3	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr21:47557204G>A	uc002zif.2	-	13	1532	c.1488C>T	c.(1486-1488)TTC>TTT	p.F496F	FTCD_uc002zie.2_RNA|FTCD_uc002zig.2_Silent_p.F496F|FTCD_uc002zih.2_Silent_p.F496F|FTCD_uc010gqf.2_Nonsense_Mutation_p.Q482*|FTCD_uc010gqg.1_Silent_p.F365F	NM_006657	NP_006648	O95954	FTCD_HUMAN	formiminotransferase cyclodeaminase	496	Cyclodeaminase/cyclohydrolase (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			pancreas(1)|skin(1)	2	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	TGAGCACGTTGAAATATGCGC	0.607													45	131					0	0	0	0	A	47557204	A	A	47557204	2	1	136	1	0	0	0	0	0	0	0	1	6115	1281	45	2		2	FTCD	21	47557204	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	6106410	47557204	572691	488	24524											
CECR6	27439	broad.mit.edu	37	chr22	17601355	17601355	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccagtacaggtcggtgacGgcgatgaggtacaggtccag	10	6	15	10	3	0	2	0	2	0	0	2	3	1	2	2	5	2	2	2	5	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:17601355G>T	uc002zmb.2	-	1	859	c.663C>A	c.(661-663)GCC>GCA	p.A221A	CECR6_uc002zma.2_Intron|uc002zmc.2_5'Flank	NM_031890	NP_114096	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	221											0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		GGTCGGTGACGGCGATGAGGT	0.706													4	20					0.00909568	0.00977588	1	0	T	17601355	T	T	17601355	2	4	136	1	0	0	0	0	0	0	0	1	3223	1103	39	3		3	CECR6	22	17601355	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08		17601355	33703211	489	24525											
DGCR14	8220	broad.mit.edu	37	chr22	19121856	19121856	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccactggccggggtcttGaggtgggtggagcgtgctgg	4	8	20	9	2	1	1	0	1	1	0	1	2	1	2	2	7	3	1	2	7	0	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:19121856G>T	uc002zou.2	-	10	1321	c.1284C>A	c.(1282-1284)CTC>CTA	p.L428L	DGCR14_uc002zot.2_Silent_p.L349L|DGCR14_uc002zov.2_RNA	NM_022719	NP_073210	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region protein 14	428					nervous system development	catalytic step 2 spliceosome				ovary(1)	1	Colorectal(54;0.0993)					CCGGGGTCTTGAGGTGGGTGG	0.687													10	30					7.48243e-07	8.85851e-07	1	0	T	19121856	T	T	19121856	2	4	136	1	0	0	0	0	0	0	0	1	4482	1277	45	2		2	DGCR14	22	19121856	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1520501	19121856	32182710	490	24526											
LZTR1	8216	broad.mit.edu	37	chr22	21333755	21333755	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcctaggggcagggctatgaCcgcactaggaagaggccggt	9	5	17	10	2	0	2	0	1	0	1	0	3	0	3	3	6	0	3	3	6	4	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:21333755C>T	uc002zto.2	+						AIFM3_uc002ztk.2_Intron|AIFM3_uc002ztj.2_Intron|AIFM3_uc002ztl.2_Intron|AIFM3_uc011ahx.1_Intron|AIFM3_uc002ztm.1_Intron|LZTR1_uc002ztn.2_5'UTR|LZTR1_uc011ahy.1_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1						anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			agggCTATGACCGCACTAGGA	0.358													6	9					0	0	0	0	T	21333755	T	T	21333755	1	4	136	0	1	0	0	0	0	0	0	0	9188	522	18	4		4	LZTR1	22	21333755	5'Flank	SNP	C	TCGA-CR-7364-01A-11D-2012-08	2211899	21333755	29970811	491	24527											
ADORA2A	135	broad.mit.edu	37	chr22	24829704	24829704	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccatccgcatcccgctccGgtgagcagggccggggttac	5	7	14	15	4	0	1	0	1	0	0	3	1	3	1	5	4	3	4	5	4	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:24829704G>T	uc002zzx.2	+	4	1095	c.332G>T	c.(331-333)CGG>CTG	p.R111L	ADORA2A_uc002zzy.3_Missense_Mutation_p.R111L|ADORA2A_uc011ajs.1_Intron|C22orf45_uc003aaa.1_5'Flank|ADORA2A_uc010guo.1_3'UTR|ADORA2A_uc010gup.2_Missense_Mutation_p.R111L|ADORA2A_uc010guq.2_Missense_Mutation_p.R111L|ADORA2A_uc003aab.2_Missense_Mutation_p.R111L|ADORA2A_uc003aac.2_5'UTR	NM_000675	NP_000666	P29274	AA2AR_HUMAN	adenosine A2a receptor	111	Cytoplasmic.				apoptosis|blood coagulation|cAMP biosynthetic process|cellular defense response|inflammatory response|nerve growth factor receptor signaling pathway|phagocytosis|sensory perception	integral to plasma membrane|membrane fraction	enzyme binding				0	Colorectal(2;0.196)				Caffeine(DB00201)|Defibrotide(DB04932)|Pegademase bovine(DB00061)|Theophylline(DB00277)	ATCCCGCTCCGGTGAGCAGGG	0.622													10	46					1.08611e-07	1.31097e-07	1	0	T	24829704	T	T	24829704	3	4	136	1	0	0	0	0	1	0	0	0	327	1130	39	3	334	3	ADORA2A	22	24829704	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	3495949	24829704	26474862	492	24528											
MYO18B	84700	broad.mit.edu	37	chr22	26422934	26422934	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcaaatgcatctcttcaGacggtgttgggggcacaacc	9	9	11	12	1	3	1	2	0	1	1	4	1	3	1	2	3	2	3	2	3	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:26422934G>T	uc003abz.1	+	43	7244	c.6994G>T	c.(6994-6996)GAC>TAC	p.D2332Y	MYO18B_uc003aca.1_Missense_Mutation_p.D2213Y|MYO18B_uc010guy.1_Missense_Mutation_p.D2214Y|MYO18B_uc010guz.1_Missense_Mutation_p.D2212Y|MYO18B_uc011aka.1_Missense_Mutation_p.D1486Y|MYO18B_uc011akb.1_Missense_Mutation_p.D1845Y|MYO18B_uc010gva.1_Missense_Mutation_p.D315Y|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2332						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CATCTCTTCAGACGGTGTTGG	0.557													18	67					1.02788e-11	1.35156e-11	1	0	T	26422934	T	T	26422934	3	4	136	1	0	0	0	0	1	0	0	0	10119	942	33	2	7160	2	MYO18B	22	26422934	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1593230	26422934	24881632	493	24529											
EWSR1	2130	broad.mit.edu	37	chr22	29684763	29684763	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgggcggggaggaggacGcggtggaatggggtaagagc	9	4	24	4	3	0	1	0	0	0	1	0	5	0	5	0	10	1	1	0	10	2	1	rs71329463		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:29684763G>T	uc003aet.2	+	8	1290	c.962G>T	c.(961-963)CGC>CTC	p.R321L	EWSR1_uc003aes.3_Missense_Mutation_p.R321L|EWSR1_uc003aev.2_Missense_Mutation_p.R327L|EWSR1_uc003aew.2_Missense_Mutation_p.R265L|EWSR1_uc003aex.2_Missense_Mutation_p.R321L|EWSR1_uc003aey.2_Missense_Mutation_p.R116L|EWSR1_uc003aez.2_5'Flank	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	321	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						GGAGGAGGACGCGGTGGAATG	0.512			T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								4	19					0.00909568	0.00977588	1	0	T	29684763	T	T	29684763	3	4	136	1	0	0	0	0	1	0	0	0	5320	1087	38	3	1014	3	EWSR1	22	29684763	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	3261829	29684763	21619803	494	24530											
GAL3ST1	9514	broad.mit.edu	37	chr22	30951150	30951150	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctcgtcctggatggcggcGgcgtccacggcgtggccccc	2	6	16	17	6	0	0	0	0	0	0	3	1	2	1	5	6	0	0	5	6	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:30951150G>A	uc003aig.1	-	4	1202	c.1062C>T	c.(1060-1062)GCC>GCT	p.A354A	GAL3ST1_uc003aih.1_Silent_p.A354A|GAL3ST1_uc003aii.1_Silent_p.A354A|GAL3ST1_uc010gvz.1_Silent_p.A354A	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	354	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						GGATGGCGGCGGCGTCCACGG	0.716													19	39					0	0	0	0	A	30951150	A	A	30951150	2	1	136	1	0	0	0	0	0	0	0	1	6232	1103	39	1		1	GAL3ST1	22	30951150	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1266387	30951150	20353416	495	24531											
SLC5A4	6527	broad.mit.edu	37	chr22	32651265	32651265	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcggatgtggtcagacaatgGaggtggctctggggtctcag	7	10	17	7	1	3	1	2	0	2	1	5	3	3	3	0	7	0	1	0	7	1	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:32651265G>C	uc003ami.2	-	1	54	c.52C>G	c.(52-54)CCA>GCA	p.P18A		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	18	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						TCAGACAATGGAGGTGGCTCT	0.522											OREG0003502	type=REGULATORY REGION|Gene=SLC5A4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	71	209					0	0	0	0	C	32651265	C	C	32651265	3	2	136	1	0	0	0	0	1	0	0	0	14731	1174	41	2	1987	2	SLC5A4	22	32651265	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	1700115	32651265	18653301	496	24532											
CYP2D6	1565	broad.mit.edu	37	chr22	42525169	42525169	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctcgcgccacgcgggcccaTagcgcgccaggaacacccct	7	3	12	19	6	0	0	0	0	0	0	1	1	0	1	5	2	2	1	5	2	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:42525169T>C	uc003bce.2	-	3	461	c.371A>G	c.(370-372)TAT>TGT	p.Y124C	uc003bcd.1_Intron|CYP2D6_uc010gyu.2_Intron|CYP2D6_uc003bcf.2_Intron	NM_000106	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D,	124							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			breast(1)|skin(1)	2						CGCGGGCCCATAGCGCGCCAG	0.682													19	33					0	0	0	0	C	42525169	C	C	42525169	3	2	136	1	0	0	0	0	1	0	0	0	4186	1406	49	5	1150	5	CYP2D6	22	42525169	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	9873904	42525169	8779397	497	24533											
CYB5R3	1727	broad.mit.edu	37	chr22	43015836	43015836	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtccaggttgggaaggcaGgcgtactggatcatgggtgg	7	9	19	6	1	1	0	1	0	0	0	2	2	2	2	1	8	1	3	1	8	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:43015836G>C	uc003bcz.2	-	9	933	c.849C>G	c.(847-849)GCC>GCG	p.A283A	CYB5R3_uc010gzc.1_Silent_p.A157A|CYB5R3_uc003bcw.2_Silent_p.A273A|CYB5R3_uc011aps.1_Silent_p.A316A|CYB5R3_uc003bcy.2_Silent_p.A260A|CYB5R3_uc003bcx.2_Silent_p.A260A	NM_000398	NP_000389	P00387	NB5R3_HUMAN	cytochrome b5 reductase 3 isoform m	283					blood circulation|cholesterol biosynthetic process|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|hemoglobin complex|mitochondrial outer membrane	cytochrome-b5 reductase activity			skin(1)	1					NADH(DB00157)	TGGGAAGGCAGGCGTACTGGA	0.682													6	17					0	0	0	0	C	43015836	C	C	43015836	2	2	136	1	0	0	0	0	0	0	0	1	4145	987	35	4		4	CYB5R3	22	43015836	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	490667	43015836	8288730	498	24534											
IL17REL	400935	broad.mit.edu	37	chr22	50439538	50439538	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtgatggaggcgcgtacacGcaggagcatcgcgcagccgt	8	5	17	11	6	0	1	0	1	0	0	1	3	0	3	1	4	3	4	1	4	1	1	rs147243670		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:50439538G>C	uc003bje.1	-	4	314	c.82C>G	c.(82-84)CGT>GGT	p.R28G		NM_001001694	NP_001001694	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	28										pancreas(1)	1		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GCGCGTACACGCAGGAGCATC	0.652													8	14					0	0	0	0	C	50439538	C	C	50439538	3	2	136	1	0	0	0	0	1	0	0	0	7683	1087	38	3	972	3	IL17REL	22	50439538	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	7423702	50439538	865028	499	24535											
CHKB	1120	broad.mit.edu	37	chr22	51018496	51018496	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acccactcacaaaaatggttCccaatgtcaaagcccctggg	13	7	7	14	0	2	0	2	0	0	0	3	0	3	0	4	2	1	1	4	2	4	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chr22:51018496C>G	uc003bms.2	-	8	1052	c.834G>C	c.(832-834)GGG>GGC	p.G278G	CPT1B_uc003bmk.3_5'Flank|CPT1B_uc003bml.2_5'Flank|CPT1B_uc003bmm.2_5'Flank|CPT1B_uc003bmo.2_5'Flank|CPT1B_uc011asa.1_5'Flank|CPT1B_uc003bmn.2_5'Flank|CPT1B_uc011asb.1_5'Flank|CHKB-CPT1B_uc003bmp.2_5'Flank|CHKB-CPT1B_uc003bmt.1_Silent_p.G69G|CHKB-CPT1B_uc003bmu.2_Silent_p.G157G|CHKB_uc003bmv.2_Silent_p.G278G|LOC100144603_uc003bmw.3_5'Flank	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	278					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	AAAAATGGTTCCCAATGTCAA	0.493													37	104					0	0	0	0	G	51018496	G	G	51018496	2	3	136	1	0	0	0	0	0	0	0	1	3363	842	30	2		2	CHKB	22	51018496	Silent	SNP	C	TCGA-CR-7364-01A-11D-2012-08	578958	51018496	286070	500	24536											
PLCXD1	55344	broad.mit.edu	37	chrX	209702	209702	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttaactctggtcctttgcagGaggtgccgacactgcggcag	7	10	13	11	2	1	0	0	0	1	0	2	2	2	1	2	4	4	2	2	4	1	2	rs146046082		TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:209702G>T	uc004cpc.2	+	6	862	c.550G>T	c.(550-552)GAG>TAG	p.E184*	PLCXD1_uc011mgx.1_RNA	NM_018390	NP_060860	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X	184	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process		phospholipase C activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCCTTTGCAGGAGGTGCCGAC	0.667													8	35					5.18039e-06	5.97291e-06	1	0	T	209702	T	T	209702	4	4	136	1	0	0	0	0	0	1	0	0	12096	1188	41	2	568	2	PLCXD1	23	209702	Nonsense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08		209702	155060858	501	24537											
MXRA5	25878	broad.mit.edu	37	chrX	3235326	3235327	+	Frame_Shift_Del	DEL	GC	-	-																															acgttcagctgcaccgtcctGcgcgcggagcctaccaggtt																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:3235326_3235327delGC	uc004crg.3	-	6	6552_6553	c.6395_6396delGC	c.(6394-6396)CGCfs	p.R2132fs		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2132	Ig-like C2-type 5.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCACCGTCCTGCGCGCGGAGCC	0.663													---	---	---								-	3235327	-	-	3235326	7	5	136	1	0	1	0	1	0	0	0	0	10056	1306	46	0	2098	0	MXRA5	23	3235326	Frame_Shift_Del	DEL	GC	TCGA-CR-7364-01A-11D-2012-08	3025624	3235326	152035234	502	24538											
PIGA	5277	broad.mit.edu	37	chrX	15344163	15344163	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tattataccactaagcaaatCgatccctgaaaatataaagt	18	11	4	8	1	0	1	0	1	0	0	2	2	1	1	2	0	2	1	2	0	10	6			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:15344163C>T	uc004cwr.2	-	3	821	c.721G>A	c.(721-723)GAT>AAT	p.D241N	PIGA_uc010neu.2_5'Flank|PIGA_uc004cwq.2_5'UTR|PIGA_uc010nev.2_Intron|PIGA_uc004cws.2_5'UTR|PIGA_uc011miq.1_Missense_Mutation_p.D7N|PIGA_uc010new.1_Missense_Mutation_p.R116Q	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	241	Cytoplasmic (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)					CTAAGCAAATCGATCCCTGAA	0.303													24	32					0	0	0	0	T	15344163	T	T	15344163	3	4	136	1	0	0	0	0	1	0	0	0	11939	884	31	1	749	1	PIGA	23	15344163	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	12108837	15344163	139926397	503	24539											
YY2	404281	broad.mit.edu	37	chrX	21875522	21875522	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acaccagctggtccacaccgGcgagaagccctttcagtgca	10	6	10	15	2	1	1	1	0	0	1	2	2	2	1	4	2	3	2	4	2	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:21875522G>T	uc011mjp.1	+	1	920	c.920G>T	c.(919-921)GGC>GTC	p.G307V	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Missense_Mutation_p.G525V|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	307	Mediates transcriptional repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GTCCACACCGGCGAGAAGCCC	0.547													90	84					2.62214e-60	4.16576e-60	1	0	T	21875522	T	T	21875522	3	4	136	1	0	0	0	0	1	0	0	0	17577	1203	42	4	922	4	YY2	23	21875522	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	6531359	21875522	133395038	504	24540											
FAM47A	158724	broad.mit.edu	37	chrX	34149264	34149264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cactccagtcttggaaggctCcgcgtggagactggaccccc	7	7	12	15	2	1	1	0	0	1	1	3	4	3	3	4	4	0	1	4	4	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:34149264C>T	uc004ddg.2	-	1	1165	c.1132G>A	c.(1132-1134)GAG>AAG	p.E378K		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	378										ovary(4)|central_nervous_system(1)	5						TTGGAAGGCTCCGCGTGGAGA	0.637													32	26					0	0	0	0	T	34149264	T	T	34149264	3	4	136	1	0	0	0	0	1	0	0	0	5601	864	30	2	1247	2	FAM47A	23	34149264	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	12273742	34149264	121121296	505	24541											
USP9X	8239	broad.mit.edu	37	chrX	41077827	41077827	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccatgtccttcaccttttGcctctcctggaccttctagt	4	15	7	15	0	3	0	1	0	2	0	5	1	4	1	6	2	1	0	6	2	1	5			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:41077827G>A	uc004dfb.2	+	37	7045	c.6412G>A	c.(6412-6414)GCC>ACC	p.A2138T	USP9X_uc004dfc.2_Missense_Mutation_p.A2138T	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2138					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TTCACCTTTTGCCTCTCCTGG	0.428													39	26					0	0	0	0	A	41077827	A	A	41077827	3	1	136	1	0	0	0	0	1	0	0	0	17158	1319	46	4	6554	4	USP9X	23	41077827	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	6928563	41077827	114192733	506	24542											
ZMYM3	9203	broad.mit.edu	37	chrX	70463741	70463741	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atatcgttcaccattgggccGagtgatttctctcacaaact	10	13	7	11	2	3	1	2	1	1	0	5	2	3	1	2	1	1	1	2	1	2	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:70463741G>A	uc004dzh.1	-	21	3457	c.3370C>T	c.(3370-3372)CGG>TGG	p.R1124W	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.R1124W|ZMYM3_uc004dzj.1_Missense_Mutation_p.R1112W	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1124					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CCATTGGGCCGAGTGATTTCT	0.493													28	20					0	0	0	0	A	70463741	A	A	70463741	3	1	136	1	0	0	0	0	1	0	0	0	17768	1057	37	1	762	1	ZMYM3	23	70463741	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	29385914	70463741	84806819	507	24543											
NONO	4841	broad.mit.edu	37	chrX	70514351	70514351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcggaaagctctggacagatGcagtgaaggctccttcctgc	9	9	12	11	1	1	2	0	1	1	1	4	4	3	4	2	3	3	3	2	3	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:70514351G>A	uc004dzo.2	+	6	1333	c.623G>A	c.(622-624)TGC>TAC	p.C208Y	BCYRN1_uc011mpt.1_Intron|NONO_uc004dzn.2_Missense_Mutation_p.C208Y|NONO_uc004dzp.2_Missense_Mutation_p.C208Y|NONO_uc011mpv.1_Missense_Mutation_p.C119Y|NONO_uc004dzq.2_Missense_Mutation_p.C77Y	NM_001145408	NP_001138880	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	208	RRM 2.|DBHS.				DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	ovary(2)|kidney(2)	4	Renal(35;0.156)					CTGGACAGATGCAGTGAAGGC	0.502			T	TFE3	papillary renal cancer								6	6					0	0	0	0	A	70514351	A	A	70514351	3	1	136	1	0	0	0	0	1	0	0	0	10588	1319	46	4	633	4	NONO	23	70514351	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	50610	70514351	84756209	508	24544											
DACH2	117154	broad.mit.edu	37	chrX	85950137	85950137	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccagccaggcattgggggtGctccaaccctcaatccactg	8	7	11	15	0	1	0	1	0	0	0	3	0	3	0	5	3	3	2	5	3	2	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:85950137G>T	uc004eew.2	+	5	1056	c.886G>T	c.(886-888)GCT>TCT	p.A296S	DACH2_uc004eex.2_Missense_Mutation_p.A283S|DACH2_uc010nmq.2_Missense_Mutation_p.A162S|DACH2_uc011mra.1_Missense_Mutation_p.A129S|DACH2_uc010nmr.2_Missense_Mutation_p.A77S	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding	p.A296A(1)		ovary(4)|pancreas(1)	5						CATTGGGGGTGCTCCAACCCT	0.498													8	4					5.18039e-06	5.97291e-06	1	0	T	85950137	T	T	85950137	3	4	136	1	0	0	0	0	1	0	0	0	4238	1319	46	4	904	4	DACH2	23	85950137	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	15435786	85950137	69320423	509	24545											
KLHL4	56062	broad.mit.edu	37	chrX	86773057	86773057	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttcagggcaggttgaagaGccactctcgggacagaaacg	11	6	15	9	2	2	3	1	1	1	2	3	4	2	4	1	4	2	3	1	4	2	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:86773057G>T	uc004efb.2	+	1	343	c.161G>T	c.(160-162)AGC>ATC	p.S54I	KLHL4_uc004efa.2_Missense_Mutation_p.S54I	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	54						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AGGTTGAAGAGCCACTCTCGG	0.542													23	13					5.45024e-15	7.51841e-15	1	0	T	86773057	T	T	86773057	3	4	136	1	0	0	0	0	1	0	0	0	8430	971	34	4	163	4	KLHL4	23	86773057	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	822920	86773057	68497503	510	24546											
GPRASP1	9737	broad.mit.edu	37	chrX	101911283	101911283	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaaggtattgttgggtcctgGtttggggccagagaagagac	9	10	17	5	0	0	2	0	0	0	2	1	5	1	2	2	5	0	3	2	5	3	4			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:101911283G>C	uc004ejj.3	+	5	3243	c.2442G>C	c.(2440-2442)TGG>TGC	p.W814C	GPRASP1_uc004eji.3_Missense_Mutation_p.W814C|GPRASP1_uc010nod.2_Missense_Mutation_p.W814C	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	814	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						TTGGGTCCTGGTTTGGGGCCA	0.502													56	51					0	0	0	0	C	101911283	C	C	101911283	3	2	136	1	0	0	0	0	1	0	0	0	6761	1270	44	4	2444	4	GPRASP1	23	101911283	Missense_Mutation	SNP	G	TCGA-CR-7364-01A-11D-2012-08	15138226	101911283	53359277	511	24547											
IL1RAPL2	26280	broad.mit.edu	37	chrX	104440323	104440323	+	Frame_Shift_Del	DEL	G	-	-																															tacaaaaacaaaggtgatttGgaagagcccatcatcttttc																										TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:104440323delG	uc004elz.1	+	3	1005	c.249delG	c.(247-249)TTGfs	p.L83fs		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	83	Ig-like C2-type 1.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						AAGGTGATTTGGAAGAGCCCA	0.448													---	---	---								-	104440323	-	-	104440323	7	5	136	1	0	1	0	1	0	0	0	0	7701	1339	47	0	255	0	IL1RAPL2	23	104440323	Frame_Shift_Del	DEL	G	TCGA-CR-7364-01A-11D-2012-08	2529040	104440323	50830237	512	24548											
DCX	1641	broad.mit.edu	37	chrX	110644424	110644424	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctccctggcctgtgcacTgttgctgctagccaaggact	5	12	11	13	0	1	0	0	0	1	0	2	1	1	1	3	2	4	5	3	2	2	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:110644424T>C	uc004epd.2	-	3	914	c.742A>G	c.(742-744)AGT>GGT	p.S248G	DCX_uc011msv.1_Missense_Mutation_p.S248G|DCX_uc004epe.2_Missense_Mutation_p.S167G|DCX_uc004epf.2_Missense_Mutation_p.S167G|DCX_uc004epg.2_Missense_Mutation_p.S167G	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	248					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						GCCTGTGCACTGTTGCTGCTA	0.522													37	26					0	0	0	0	C	110644424	C	C	110644424	3	2	136	1	0	0	0	0	1	0	0	0	4335	1580	55	5	618	5	DCX	23	110644424	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	6204101	110644424	44626136	513	24549											
THOC2	57187	broad.mit.edu	37	chrX	122802034	122802034	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctactttctcctcttctttTtccttttctttctctcgctc	1	24	1	15	1	6	0	0	0	6	0	11	0	7	0	2	0	1	1	2	0	1	8			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:122802034T>A	uc004etu.2	-	10	1025	c.993A>T	c.(991-993)GAA>GAT	p.E331D	THOC2_uc011muh.1_Missense_Mutation_p.E252D|THOC2_uc011mui.1_Missense_Mutation_p.E216D	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	331	Potential.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						cctcttctttttccttttctt	0.209													41	29					0	0	0	0	A	122802034	A	A	122802034	3	1	136	1	0	0	0	0	1	0	0	0	15931	1838	64	5	3904	5	THOC2	23	122802034	Missense_Mutation	SNP	T	TCGA-CR-7364-01A-11D-2012-08	12157610	122802034	32468526	514	24550											
BCORL1	63035	broad.mit.edu	37	chrX	129149413	129149413	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acggacttcctgaggggcaaCcacggcctgggggctccttc	6	7	14	14	2	0	1	0	1	0	0	3	2	2	2	4	6	1	2	4	6	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:129149413C>T	uc004evb.1	+	4	2779	c.2665C>T	c.(2665-2667)CCA>TCA	p.P889S	BCORL1_uc010nrd.1_Missense_Mutation_p.P791S	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	889					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TGAGGGGCAACCACGGCCTGG	0.572													19	25					0	0	0	0	T	129149413	T	T	129149413	3	4	136	1	0	0	0	0	1	0	0	0	1389	507	18	4	2675	4	BCORL1	23	129149413	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	6347379	129149413	26121147	515	24551											
GPR101	83550	broad.mit.edu	37	chrX	136113046	136113046	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaccttcatgctggcggCgaaactcactctcatcctgg	7	10	8	16	2	4	0	4	0	1	0	6	1	5	0	3	3	2	1	3	3	1	1			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:136113046C>T	uc011mwh.1	-	1	788	c.788G>A	c.(787-789)CGC>CAC	p.R263H		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	263	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					ATGCTGGCGGCGAAACTCACT	0.557													58	55					0	0	0	0	T	136113046	T	T	136113046	3	4	136	1	0	0	0	0	1	0	0	0	6660	768	27	1	741	1	GPR101	23	136113046	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	6963633	136113046	19157514	516	24552											
SLITRK4	139065	broad.mit.edu	37	chrX	142717001	142717001	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttgttgcgtcgcaggaCaaaaacaagaaggcaaaaag	16	8	10	7	2	1	1	0	0	1	1	2	2	1	2	0	2	2	3	0	2	6	3			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:142717001C>A	uc004fbx.2	-	2	2300	c.1924G>T	c.(1924-1926)GTC>TTC	p.V642F	SLITRK4_uc004fby.2_Missense_Mutation_p.V642F	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	642	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CGTCGCAGGACAAAAACAAGA	0.478													53	28					9.57592e-29	1.46121e-28	1	0	A	142717001	A	A	142717001	3	1	136	1	0	0	0	0	1	0	0	0	14809	478	17	4	593	4	SLITRK4	23	142717001	Missense_Mutation	SNP	C	TCGA-CR-7364-01A-11D-2012-08	6603955	142717001	12553559	517	24553											
MAGEA10	4109	broad.mit.edu	37	chrX	151304000	151304000	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcatcctcctccacagccagGggagcctgtgcaccctcgag	7	6	11	17	1	0	0	0	0	0	0	4	2	3	1	6	2	3	2	6	2	0	0			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:151304000G>A	uc004ffk.2	-	5	501	c.93C>T	c.(91-93)CCC>CCT	p.P31P	MAGEA10_uc004ffl.2_Silent_p.P31P	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	31											0	Acute lymphoblastic leukemia(192;6.56e-05)					CCACAGCCAGGGGAGCCTGTG	0.418													34	20					0	0	0	0	A	151304000	A	A	151304000	2	1	136	1	0	0	0	0	0	0	0	1	9215	1219	43	4		4	MAGEA10	23	151304000	Silent	SNP	G	TCGA-CR-7364-01A-11D-2012-08	8586999	151304000	3966560	518	24554											
IL9R	3581	broad.mit.edu	37	chrX	155235022	155235022	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggaccctggctttatccAtgaggccaggctgcgtgtcc	5	10	13	13	1	0	1	0	1	0	0	2	2	2	2	4	4	1	3	4	4	1	2			TCGA-CR-7364-01A-11D-2012-08	TCGA-CR-7364-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5047f1e-5088-4d30-927d-e64147fe661d	76d2a8b9-826c-48a4-99f5-f5d826aac3a0	g.chrX:155235022A>T	uc004fnv.1	+	6	838	c.659A>T	c.(658-660)CAT>CTT	p.H220L	IL9R_uc010nvn.2_Missense_Mutation_p.H199L|IL9R_uc004fnu.1_Missense_Mutation_p.H255L	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	220	Extracellular (Potential).|Fibronectin type-III.				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GGCTTTATCCATGAGGCCAGG	0.582													52	55					0	0	0	0	T	155235022	T	T	155235022	3	4	136	1	0	0	0	0	1	0	0	0	7747	217	8	5	681	5	IL9R	23	155235022	Missense_Mutation	SNP	A	TCGA-CR-7364-01A-11D-2012-08	3931022	155235022	35538	519	24555											
SDF4	51150	broad.mit.edu	37	chr1	1163936	1163936	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtccttgcctaggaagacctCctggtggaagccgcgattga	8	9	13	11	2	0	2	0	1	0	1	2	5	2	4	5	3	2	0	5	3	3	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:1163936C>G	uc001adh.3	-	2	567	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	SDF4_uc001adi.3_Missense_Mutation_p.E80Q|SDF4_uc009vjv.2_Intron|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	80					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		AGGAAGACCTCCTGGTGGAAG	0.617													17	31					0	0	0	0	G	1163936	G	G	1163936	3	3	137	1	0	0	0	0	1	0	0	0	14027	864	30	2	990	2	SDF4	1	1163936	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08		1163936	248086685	1	24556											
SDF4	51150	broad.mit.edu	37	chr1	1164020	1164020	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggcaggatctcattctcctCcctgttggctactctctctc	4	14	8	15	0	4	0	1	0	4	0	9	1	5	1	2	3	1	3	2	3	1	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:1164020C>T	uc001adh.3	-	2	483	c.154G>A	c.(154-156)GAG>AAG	p.E52K	SDF4_uc001adi.3_Missense_Mutation_p.E52K|SDF4_uc009vjv.2_Intron|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	52					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		TCATTCTCCTCCCTGTTGGCT	0.627													29	44					0	0	0	0	T	1164020	T	T	1164020	3	4	137	1	0	0	0	0	1	0	0	0	14027	864	30	2	1074	2	SDF4	1	1164020	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	84	1164020	248086601	2	24557											
C1orf127	148345	broad.mit.edu	37	chr1	11007909	11007909	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgtgggagcccacaggctCagggtttgcgtggatggagg	6	8	18	9	1	1	0	1	0	0	0	1	3	1	3	2	6	2	2	2	6	0	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:11007909C>T	uc010oao.1	-	8	1841	c.1836G>A	c.(1834-1836)CTG>CTA	p.L612L	C1orf127_uc001arr.1_Silent_p.L594L|C1orf127_uc001ars.1_Silent_p.L586L	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	612										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		CCCACAGGCTCAGGGTTTGCG	0.662													5	29					0	0	0	0	T	11007909	T	T	11007909	2	4	137	1	0	0	0	0	0	0	0	1	2003	813	29	2		2	C1orf127	1	11007909	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	9843889	11007909	238242712	3	24558											
PLOD1	5351	broad.mit.edu	37	chr1	12024727	12024727	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggaatgtgccctatatttCaaacatctacttgatcaagg	12	13	7	9	0	3	1	2	1	1	0	3	2	3	2	1	2	3	0	1	2	6	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:12024727C>G	uc001atm.2	+	13	1446	c.1355C>G	c.(1354-1356)TCA>TGA	p.S452*	PLOD1_uc010obb.1_Nonsense_Mutation_p.S499*	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	452					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	CCCTATATTTCAAACATCTAC	0.587													52	68					0	0	0	0	G	12024727	G	G	12024727	4	3	137	1	0	0	0	0	0	1	0	0	12156	838	29	2	1405	2	PLOD1	1	12024727	Nonsense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	1016818	12024727	237225894	4	24559											
WDTC1	23038	broad.mit.edu	37	chr1	27632792	27632792	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcaacatgggctaccggaTcacgggcctgagcagtgggg	8	6	16	11	2	2	1	2	1	0	0	2	2	2	2	2	5	3	3	2	5	2	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:27632792T>A	uc009vst.2	+	16	2487	c.1952T>A	c.(1951-1953)ATC>AAC	p.I651N	WDTC1_uc001bno.2_Missense_Mutation_p.I650N|WDTC1_uc001bnp.1_RNA|WDTC1_uc001bnq.2_Missense_Mutation_p.I329N	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	651							protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		GGCTACCGGATCACGGGCCTG	0.647													21	38					0	0	0	0	A	27632792	A	A	27632792	3	1	137	1	0	0	0	0	1	0	0	0	17410	1435	50	5	2007	5	WDTC1	1	27632792	Missense_Mutation	SNP	T	TCGA-CR-7365-01A-11D-2012-08	15608065	27632792	221617829	5	24560											
NT5C1A	84618	broad.mit.edu	37	chr1	40129051	40129051	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggttggtgtgataggccttGaggtagcagatcgggctgtt	7	12	17	5	1	0	3	0	2	0	1	1	3	0	3	1	5	1	5	1	5	2	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:40129051G>C	uc001cdq.1	-	4	489	c.489C>G	c.(487-489)CTC>CTG	p.L163L		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	163					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GATAGGCCTTGAGGTAGCAGA	0.532													23	29					0	0	0	0	C	40129051	C	C	40129051	2	2	137	1	0	0	0	0	0	0	0	1	10739	1277	45	2		2	NT5C1A	1	40129051	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	12496259	40129051	209121570	6	24561											
CYP4A11	1579	broad.mit.edu	37	chr1	47395807	47395807	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaagctggtccttgtcttCacaagggttagggagcctcc	8	11	11	11	0	3	0	2	0	1	0	5	1	5	1	3	3	2	2	3	3	3	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:47395807C>T	uc001cqp.3	-	12	1591	c.1540G>A	c.(1540-1542)GAA>AAA	p.E514K		NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	514			NGIHLRLRRLPNPCEDKDQL -> MESTCVSGGSLTLVKTR TSFEGLHLPSCLPDPRFCPLPVCPYPVFCLPTFPSSHLPAV PQSACPSLSHLSPGLPTCLSTCLLPTCISCWEKS (in CYP4A11V).		long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	TCCTTGTCTTCACAAGGGTTA	0.353													11	43					0	0	0	0	T	47395807	T	T	47395807	3	4	137	1	0	0	0	0	1	0	0	0	4200	835	29	2	23	2	CYP4A11	1	47395807	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	7266756	47395807	201854814	7	24562											
FOXE3	2301	broad.mit.edu	37	chr1	47882283	47882283	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacgctggccgccatctaccGcttcatcaccgaacgctttg	7	9	8	17	5	3	0	2	0	1	0	3	1	3	0	4	1	2	3	4	1	2	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:47882283G>A	uc001crk.2	+	1	540	c.296G>A	c.(295-297)CGC>CAC	p.R99H		NM_012186	NP_036318	Q13461	FOXE3_HUMAN	forkhead box E3	99	Fork-head.				cell migration|embryonic organ morphogenesis|enteric nervous system development|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|pattern specification process|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		GCCATCTACCGCTTCATCACC	0.642													6	45					0	0	0	0	A	47882283	A	A	47882283	3	1	137	1	0	0	0	0	1	0	0	0	6038	1087	38	1	298	1	FOXE3	1	47882283	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	486476	47882283	201368338	8	24563											
USP24	23358	broad.mit.edu	37	chr1	55598230	55598230	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcttacttctaagttgtaGagcactctgaaggtagacat	11	15	8	7	0	3	3	0	1	3	2	3	3	3	3	0	1	2	4	0	1	5	7			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:55598230G>C	uc001cyg.3	-	28	3045	c.3045C>G	c.(3043-3045)CTC>CTG	p.L1015L		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1175					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						CTAAGTTGTAGAGCACTCTGA	0.383													29	41					0	0	0	0	C	55598230	C	C	55598230	2	2	137	1	0	0	0	0	0	0	0	1	17123	929	33	2		2	USP24	1	55598230	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	7715947	55598230	193652391	9	24564											
C1orf168	199920	broad.mit.edu	37	chr1	57216842	57216842	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtggacgttggtcatcTgaattttttcaggtgtccct	5	17	11	8	1	3	1	2	1	1	0	4	2	4	2	1	3	0	1	1	3	1	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:57216842T>C	uc001cym.3	-	9	1668	c.1262A>G	c.(1261-1263)CAG>CGG	p.Q421R	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	421										ovary(3)|skin(2)	5						GTTGGTCATCTGAATTTTTTC	0.458													3	48					0	0	0	0	C	57216842	C	C	57216842	3	2	137	1	0	0	0	0	1	0	0	0	2021	1580	55	5	972	5	C1orf168	1	57216842	Missense_Mutation	SNP	T	TCGA-CR-7365-01A-11D-2012-08	1618612	57216842	192033779	10	24565											
LRRC7	57554	broad.mit.edu	37	chr1	70504339	70504340	+	Frame_Shift_Ins	INS	-	A	A																															atcccaacaggagtcttagtINSaatgtcttttctcaaatcca																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:70504339_70504340insA	uc001dep.2	+	19	2748_2749	c.2718_2719insA	c.(2716-2721)AGTAATfs	p.S906fs	LRRC7_uc009wbg.2_Frame_Shift_Ins_p.S190fs|LRRC7_uc001deq.2_Frame_Shift_Ins_p.S147fs	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	906_907						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GGAGTCTTAGTAATGTCTTTTC	0.401													---	---	---								A	70504340	A	A	70504339	7	5	137	1	0	1	1	0	0	0	0	0	9070	1635	57	0	2792	0	LRRC7	1	70504339	Frame_Shift_Ins	INS	-	TCGA-CR-7365-01A-11D-2012-08	13287497	70504339	178746282	11	24566											
LRRIQ3	127255	broad.mit.edu	37	chr1	74507588	74507588	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaactggtatccaatttttCatccacaatttcatcttcag	13	15	3	10	0	4	0	3	0	1	0	6	0	6	0	2	1	1	1	2	1	5	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:74507588C>T	uc001dfy.3	-	7	1219	c.1027G>A	c.(1027-1029)GAA>AAA	p.E343K	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	343										ovary(2)	2						TCCAATTTTTCATCCACAATT	0.308													5	40					0	0	0	0	T	74507588	T	T	74507588	3	4	137	1	0	0	0	0	1	0	0	0	9080	835	29	2	855	2	LRRIQ3	1	74507588	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	4003249	74507588	174743033	12	24567											
SYCP1	6847	broad.mit.edu	37	chr1	115398091	115398091	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accgtaacagagaaaatggaAaagcaaaagccctttgcatt	18	7	8	8	1	0	1	0	0	0	1	0	3	0	2	2	1	4	3	2	1	7	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:115398091A>C	uc001efr.2	+	2	215	c.6A>C	c.(4-6)GAA>GAC	p.E2D	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.E2D|SYCP1_uc009wgw.2_Missense_Mutation_p.E2D	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	2					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGAAAATGGAAAAGCAAAAGC	0.483													16	44					0	0	0	0	C	115398091	C	C	115398091	3	2	137	1	0	0	0	0	1	0	0	0	15497	11	1	5	8	5	SYCP1	1	115398091	Missense_Mutation	SNP	A	TCGA-CR-7365-01A-11D-2012-08	40890503	115398091	133852530	13	24568											
HIST2H3D	653604	broad.mit.edu	37	chr1	149784921	149784921	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcgcacaggttcgtgtcttCgaacagccccaccaggtagg	8	7	13	13	3	1	0	0	0	1	0	3	1	1	0	3	4	2	3	3	4	2	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:149784921C>T	uc010pbl.1	-	1	316	c.316G>A	c.(316-318)GAA>AAA	p.E106K	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	106					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						TTCGTGTCTTCGAACAGCCCC	0.652													11	51					0	0	0	0	T	149784921	T	T	149784921	3	4	137	1	0	0	0	0	1	0	0	0	7220	893	31	1	96	1	HIST2H3D	1	149784921	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	34386830	149784921	99465700	14	24569											
TUFT1	7286	broad.mit.edu	37	chr1	151542192	151542206	+	In_Frame_Del	DEL	GGCCAAGCTTCAGGA	-	-																															aagacggtgcaggacttgctGgccaagcttcaggaggccaa																								rs149655288		TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:151542192_151542206delGGCCAAGCTTCAGGA	uc001eyl.2	+	7	602_616	c.540_554delGGCCAAGCTTCAGGA	c.(538-555)CTGGCCAAGCTTCAGGAG>CTG	p.AKLQE181del	TUFT1_uc001eym.2_In_Frame_Del_p.AKLQE156del|TUFT1_uc010pdf.1_In_Frame_Del_p.AKLQE200del|TUFT1_uc010pdg.1_In_Frame_Del_p.AKLQE129del	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1	181_185	Potential.				bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGGACTTGCTGGCCAAGCTTCAGGAGGCCAAGCGG	0.54													---	---	---								-	151542206	-	-	151542192	7	5	137	1	0	1	0	1	0	0	0	0	16840	1335	47	0	566	0	TUFT1	1	151542192	In_Frame_Del	DEL	GGCCAAGCTTCAGGA	TCGA-CR-7365-01A-11D-2012-08	1757271	151542192	97708429	15	24570											
MUC1	4582	broad.mit.edu	37	chr1	155161971	155161971	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtacgctgctggtcatactCacagcattcttctcagtaga	10	12	8	11	1	4	1	3	0	2	1	5	1	4	1	0	1	4	5	0	1	3	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:155161971C>G	uc010pft.1	-	2	228	c.162G>C	c.(160-162)GTG>GTC	p.V54V	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_5'Flank|MUC1_uc001fhz.2_5'Flank|MUC1_uc010pfb.1_Intron|MUC1_uc010pfc.1_Intron|MUC1_uc009wph.2_Intron|MUC1_uc010pfd.1_Intron|MUC1_uc010pfe.1_Intron|MUC1_uc010pff.1_Intron|MUC1_uc009wpi.2_Intron|MUC1_uc010pfg.1_Intron|MUC1_uc010pfh.1_Intron|MUC1_uc010pfi.1_Intron|MUC1_uc010pfj.1_Intron|MUC1_uc010pfk.1_Intron|MUC1_uc010pfl.1_Intron|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Intron|MUC1_uc001fip.2_Intron|MUC1_uc009wqg.2_Intron|MUC1_uc009wpo.2_Intron|MUC1_uc009wps.2_Intron|MUC1_uc009wpt.2_Intron|MUC1_uc001fic.2_Intron|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Intron|MUC1_uc009wpv.2_Intron|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Intron|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Intron|MUC1_uc001fid.2_Intron|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Intron|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Intron|MUC1_uc001fiq.2_Intron|MUC1_uc009wpz.2_Intron|MUC1_uc010pfn.1_Intron|MUC1_uc009wqa.2_Intron|MUC1_uc010pfo.1_Intron|MUC1_uc010pfp.1_Intron|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Intron|MUC1_uc009wqc.2_Intron|MUC1_uc009wqd.2_Intron|MUC1_uc009wqb.2_Intron|MUC1_uc010pfq.1_Intron|MUC1_uc010pfr.1_Intron|MUC1_uc001fit.2_Intron|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Intron|MUC1_uc009wpm.2_Intron|MUC1_uc009wpp.2_Intron|MUC1_uc010pfs.1_Intron|MUC1_uc001fik.2_Intron|MUC1_uc001fio.2_Intron|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Intron|MUC1_uc001fis.1_Intron|uc009wqh.2_5'Flank|MUC1_uc001fiv.1_Silent_p.V63V|MUC1_uc001fiw.1_Silent_p.V54V|MIR92B_hsa-mir-92b|MI0003560_5'Flank			P15941	MUC1_HUMAN	SubName: Full=MUC1 isoform M13;	54	Extracellular (Potential).					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGTCATACTCACAGCATTCT	0.577			T	IGH@	B-NHL								21	115					0	0	0	0	G	155161971	G	G	155161971	2	3	137	1	0	0	0	0	0	0	0	1	10023	841	29	2		2	MUC1	1	155161971	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	3619779	155161971	94088650	16	24571											
SELE	6401	broad.mit.edu	37	chr1	169694892	169694892	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattcttttgaacttaaaggAtgtaagaaggcttttggtag	12	15	11	3	0	1	2	0	1	1	1	1	4	1	3	0	3	1	3	0	3	6	8			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:169694892A>C	uc001ggm.3	-	13	1983	c.1826T>G	c.(1825-1827)ATC>AGC	p.I609S	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	609	Cytoplasmic (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					AACTTAAAGGATGTAAGAAGG	0.408													13	26					0	0	0	0	C	169694892	C	C	169694892	3	2	137	1	0	0	0	0	1	0	0	0	14078	333	12	5	10	5	SELE	1	169694892	Missense_Mutation	SNP	A	TCGA-CR-7365-01A-11D-2012-08	14532921	169694892	79555729	17	24572											
PRDX6	9588	broad.mit.edu	37	chr1	173456943	173456943	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaacttttcccgaaaggaGtcttcaccaaagagctccca	15	8	6	12	1	2	1	1	0	1	1	4	3	4	2	3	1	2	1	3	1	4	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:173456943G>T	uc001giy.1	+	5	667	c.616G>T	c.(616-618)GTC>TTC	p.V206F		NM_004905	NP_004896	P30041	PRDX6_HUMAN	peroxiredoxin 6	206					cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			central_nervous_system(1)	1						CCCGAAAGGAGTCTTCACCAA	0.478													38	42					1.07121e-22	1.22859e-22	1	0	T	173456943	T	T	173456943	3	4	137	1	0	0	0	0	1	0	0	0	12531	1029	36	4	634	4	PRDX6	1	173456943	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	3762051	173456943	75793678	18	24573											
TDRD5	163589	broad.mit.edu	37	chr1	179659915	179659915	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagacaagcgtcaagaatCtgtagaccagctgtctttga	14	9	9	9	1	3	4	1	1	2	3	3	4	3	4	1	0	2	2	1	0	5	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:179659915C>G	uc001gnf.1	+	17	3033	c.2783C>G	c.(2782-2784)TCT>TGT	p.S928C	TDRD5_uc010pnp.1_Missense_Mutation_p.S982C|TDRD5_uc001gnh.1_Missense_Mutation_p.S483C	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	928					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CGTCAAGAATCTGTAGACCAG	0.438													13	47					0	0	0	0	G	179659915	G	G	179659915	3	3	137	1	0	0	0	0	1	0	0	0	15799	913	32	2	2845	2	TDRD5	1	179659915	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	6202972	179659915	69590706	19	24574											
RGL1	23179	broad.mit.edu	37	chr1	183816705	183816705	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taatttattatacaggttgaAggggaccagctgcctccagg	11	11	11	8	0	0	1	0	1	0	0	1	2	1	2	3	4	3	2	3	4	5	6			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:183816705A>G	uc001gqo.2	+	3	301	c.144A>G	c.(142-144)GAA>GAG	p.E48E	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Silent_p.E83E|RGL1_uc010pog.1_Silent_p.E46E|RGL1_uc010poh.1_Silent_p.E46E|RGL1_uc010poi.1_Silent_p.E48E	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	48					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						TACAGGTTGAAGGGGACCAGC	0.418													3	172					0	0	0	0	G	183816705	G	G	183816705	2	3	137	1	0	0	0	0	0	0	0	1	13341	69	3	5		5	RGL1	1	183816705	Silent	SNP	A	TCGA-CR-7365-01A-11D-2012-08	4156790	183816705	65433916	20	24575											
PPFIA4	8497	broad.mit.edu	37	chr1	203025593	203025593	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacccaggacgctgcggctaGagaagcttggccacccagcc	9	4	12	16	2	0	1	0	0	0	1	0	3	0	2	4	3	3	3	4	3	2	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:203025593G>C	uc001gyz.2	+	5	1272	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	PPFIA4_uc009xaj.2_Missense_Mutation_p.E858Q|PPFIA4_uc010pqf.1_Missense_Mutation_p.E440Q|PPFIA4_uc001gza.2_Missense_Mutation_p.E227Q|PPFIA4_uc001gzb.1_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	227					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GCTGCGGCTAGAGAAGCTTGG	0.567													8	30					0	0	0	0	C	203025593	C	C	203025593	3	2	137	1	0	0	0	0	1	0	0	0	12367	943	33	2	697	2	PPFIA4	1	203025593	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	19208888	203025593	46225028	21	24576											
NSL1	25936	broad.mit.edu	37	chr1	212965008	212965008	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcacccgaaagtcttctCggggagtggcggagaccaag	10	5	15	11	4	2	1	0	0	2	1	3	4	2	2	2	4	1	1	2	4	2	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:212965008C>A	uc001hjn.2	-	1	132	c.98G>T	c.(97-99)CGA>CTA	p.R33L	NSL1_uc001hjm.2_Missense_Mutation_p.R33L|NSL1_uc010pti.1_Missense_Mutation_p.R33L|TATDN3_uc001hjo.2_5'Flank|TATDN3_uc010ptj.1_5'Flank|TATDN3_uc010ptk.1_5'Flank|TATDN3_uc001hjp.2_5'Flank|TATDN3_uc010ptl.1_5'Flank	NM_015471	NP_056286	Q96IY1	NSL1_HUMAN	NSL1, MIND kinetochore complex component isoform	33					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00597)|all cancers(67;0.00893)|GBM - Glioblastoma multiforme(131;0.0514)|Epithelial(68;0.102)		AAAGTCTTCTCGGGGAGTGGC	0.632													31	58					1.39806e-14	1.56634e-14	1	0	A	212965008	A	A	212965008	3	1	137	1	0	0	0	0	1	0	0	0	10727	884	31	3	860	3	NSL1	1	212965008	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	9939415	212965008	36285613	22	24577											
PTPN14	5784	broad.mit.edu	37	chr1	214549657	214549657	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggacaacttcacggattcGgctgcgctcggcgttttctg	5	11	14	11	5	2	0	1	0	1	0	4	2	2	2	0	5	2	3	0	5	1	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:214549657G>A	uc001hkk.1	-	15	3083	c.2812C>T	c.(2812-2814)CGA>TGA	p.R938*	PTPN14_uc010pty.1_Nonsense_Mutation_p.R839*	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	938	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TCACGGATTCGGCTGCGCTCG	0.458													31	55					0	0	0	0	A	214549657	A	A	214549657	4	1	137	1	0	0	0	0	0	1	0	0	12846	1124	39	1	771	1	PTPN14	1	214549657	Nonsense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	1584649	214549657	34700964	23	24578											
LIN9	286826	broad.mit.edu	37	chr1	226465500	226465500	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactttcgttccaataaccaGaggcaaaggaatttcatctg	14	11	7	9	1	2	1	1	0	1	1	4	2	3	2	2	2	2	2	2	2	5	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:226465500G>A	uc001hqa.2	-	7	1016	c.706C>T	c.(706-708)CTG>TTG	p.L236L	LIN9_uc001hqb.2_Silent_p.L201L|LIN9_uc001hqc.2_Silent_p.L168L|LIN9_uc009xel.1_Silent_p.L201L	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	220	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		CCAATAACCAGAGGCAAAGGA	0.333													12	48					0	0	0	0	A	226465500	A	A	226465500	2	1	137	1	0	0	0	0	0	0	0	1	8855	933	33	2		2	LIN9	1	226465500	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	11915843	226465500	22785121	24	24579											
OR2M5	127059	broad.mit.edu	37	chr1	248309245	248309245	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acatacggcccacatctgatCgctcccctatgcaggacaag	11	7	8	15	2	1	1	0	1	1	0	3	2	2	2	3	2	2	2	3	2	3	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:248309245C>T	uc010pze.1	+	1	796	c.796C>T	c.(796-798)CGC>TGC	p.R266C		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CACATCTGATCGCTCCCCTAT	0.522													65	94					0	0	0	0	T	248309245	T	T	248309245	3	4	137	1	0	0	0	0	1	0	0	0	11067	884	31	1	798	1	OR2M5	1	248309245	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	21843745	248309245	941376	25	24580											
OR2T6	254879	broad.mit.edu	37	chr1	248551737	248551737	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagataaggtcttctctgcCttttataccatcctcacacc	11	13	4	13	0	3	1	1	0	2	1	5	1	4	1	4	1	2	0	4	1	4	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:248551737C>A	uc001iei.1	+	1	828	c.828C>A	c.(826-828)GCC>GCA	p.A276A		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCTTCTCTGCCTTTTATACCA	0.463													16	69					4.7546e-09	5.11384e-09	1	0	A	248551737	A	A	248551737	2	1	137	1	0	0	0	0	0	0	0	1	11083	668	24	4		4	OR2T6	1	248551737	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	242492	248551737	698884	26	24581											
PRKD3	23683	broad.mit.edu	37	chr2	37501611	37501611	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcaaacacttgcttgaggaGtaacaggcatgagggcttgg	11	9	14	7	0	0	2	0	2	0	0	0	3	0	3	0	4	4	5	0	4	2	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:37501611G>A	uc002rqd.2	-	10	2159	c.1604C>T	c.(1603-1605)ACT>ATT	p.T535I	PRKD3_uc002rqe.1_Missense_Mutation_p.T135I|PRKD3_uc002rqf.1_Missense_Mutation_p.T535I	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	535					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				TGCTTGAGGAGTAACAGGCAT	0.453													18	45					0	0	0	0	A	37501611	A	A	37501611	3	1	137	1	0	0	0	0	1	0	0	0	12582	1029	36	4	1104	4	PRKD3	2	37501611	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08		37501611	205697762	27	24582											
PLEK	5341	broad.mit.edu	37	chr2	68620335	68620335	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagtgaggaagttcatcttGagagaagaccctgcctacct	13	9	10	9	0	2	4	1	2	1	2	2	6	2	5	3	1	2	1	3	1	4	3	rs146499837		TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:68620335G>C	uc002sen.3	+	7	966	c.804G>C	c.(802-804)TTG>TTC	p.L268F	PLEK_uc010fde.2_Missense_Mutation_p.L268F	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	268	PH 2.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AGTTCATCTTGAGAGAAGACC	0.423													45	130					0	0	0	0	C	68620335	C	C	68620335	3	2	137	1	0	0	0	0	1	0	0	0	12108	1281	45	2	830	2	PLEK	2	68620335	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	31118724	68620335	174579038	28	24583											
BMP10	27302	broad.mit.edu	37	chr2	69093522	69093522	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctcattatcccctttgctCtccagcacttcaaaaatggt	9	13	4	15	0	3	0	2	0	1	0	5	0	4	0	4	1	2	2	4	1	3	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:69093522C>T	uc002sez.1	-	2	675	c.516G>A	c.(514-516)GAG>GAA	p.E172E		NM_014482	NP_055297	O95393	BMP10_HUMAN	bone morphogenetic protein 10 preproprotein	172					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			ovary(2)	2						CCCCTTTGCTCTCCAGCACTT	0.448													25	61					0	0	0	0	T	69093522	T	T	69093522	2	4	137	1	0	0	0	0	0	0	0	1	1460	912	32	2		2	BMP10	2	69093522	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	473187	69093522	174105851	29	24584											
NAT8	9027	broad.mit.edu	37	chr2	73868736	73868737	+	Missense_Mutation	DNP	CG	GA	GA																															ggtcgctctcctggtatttgCggatgtgacaaggagccatg																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:73868736_73868737CG>GA	uc002sji.1	-	2	186_187	c.19_20CG>TC	c.(19-21)CGC>TCC	p.R7S		NM_003960	NP_003951	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8	7					gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			ovary(1)	1						CTGGTATTTGCGGATGTGACAA	0.589													33	84					0	0	0	0	GA	73868737	GA	GA	73868736	3	3	137	1	0	0	0	0	1	0	0	0	10232	768	27	3	667	3	NAT8	2	73868736	Missense_Mutation	DNP	CG	TCGA-CR-7365-01A-11D-2012-08	4775214	73868736	169330637	30	24585											
C2orf65	130951	broad.mit.edu	37	chr2	74785901	74785901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagaaggcatctgaggaaGatttgctggctgctggcatc	10	9	15	7	0	1	3	0	1	1	2	2	5	1	5	0	5	2	5	0	5	3	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:74785901G>A	uc002smy.2	-	11	1652	c.1535C>T	c.(1534-1536)TCT>TTT	p.S512F	C2orf65_uc010ysa.1_Missense_Mutation_p.S508F|C2orf65_uc010ffp.2_Missense_Mutation_p.S161F|C2orf65_uc002smx.2_Missense_Mutation_p.S264F	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	512					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						ATCTGAGGAAGATTTGCTGGC	0.587													14	85					0	0	0	0	A	74785901	A	A	74785901	3	1	137	1	0	0	0	0	1	0	0	0	2194	942	33	2	61	2	C2orf65	2	74785901	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	917165	74785901	168413472	31	24586											
C2orf89	129293	broad.mit.edu	37	chr2	85097636	85097636	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	catcatgagcttgacatactCcaggtggcgcttgaggcggc	8	9	13	11	2	1	3	1	3	0	0	2	3	2	3	1	4	2	2	1	4	1	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:85097636C>G	uc010ysl.1	-	2	471	c.382G>C	c.(382-384)GAG>CAG	p.E128Q	C2orf89_uc002sou.3_Missense_Mutation_p.E128Q|C2orf89_uc010fgc.1_Missense_Mutation_p.E128Q	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	128	Extracellular (Potential).					integral to membrane				ovary(1)	1						TTGACATACTCCAGGTGGCGC	0.577													15	39					0	0	0	0	G	85097636	G	G	85097636	3	3	137	1	0	0	0	0	1	0	0	0	2213	864	30	2	1008	2	C2orf89	2	85097636	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	10311735	85097636	158101737	32	24587											
IL1B	3553	broad.mit.edu	37	chr2	113591119	113591119	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcgtagctggatgccgccatCcagagggcagaggtccaggt	8	7	15	11	2	0	2	0	0	0	2	3	3	2	3	4	4	2	3	4	4	1	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:113591119C>A	uc002tii.1	-	4	220	c.133G>T	c.(133-135)GAT>TAT	p.D45Y	IL1B_uc002tih.1_Missense_Mutation_p.D14Y	NM_000576	NP_000567	P01584	IL1B_HUMAN	interleukin 1, beta proprotein	45					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			lung(3)|breast(1)	4					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	ATGCCGCCATCCAGAGGGCAG	0.602													29	55					9.39395e-14	1.03805e-13	1	0	A	113591119	A	A	113591119	3	1	137	1	0	0	0	0	1	0	0	0	7690	855	30	2	692	2	IL1B	2	113591119	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	28493483	113591119	129608254	33	24588											
LCT	3938	broad.mit.edu	37	chr2	136579616	136579616	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaacttgatgaacaactCagaaactcattaatatcaaa	18	11	5	7	0	3	3	3	2	0	1	3	4	3	4	0	1	4	0	0	1	7	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:136579616C>A	uc002tuu.1	-	5	971	c.960G>T	c.(958-960)CTG>CTT	p.L320L	uc002tuv.1_RNA	NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	320	Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATGAACAACTCAGAAACTCAT	0.264													13	31					1.05317e-09	1.1429e-09	1	0	A	136579616	A	A	136579616	2	1	137	1	0	0	0	0	0	0	0	1	8733	813	29	2		2	LCT	2	136579616	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	22988497	136579616	106619757	34	24589											
ACVR1	90	broad.mit.edu	37	chr2	158617419	158617419	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caccatccgcctggccacttCccacaaaacaagtccaaagg	13	5	6	17	1	0	0	0	0	0	0	3	0	3	0	6	2	1	0	6	2	4	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:158617419C>G	uc002tzm.3	-	10	1576	c.1237G>C	c.(1237-1239)GAA>CAA	p.E413Q	ACVR1_uc002tzn.3_Missense_Mutation_p.E413Q|ACVR1_uc010fog.2_Missense_Mutation_p.E413Q	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	413	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	CTGGCCACTTCCCACAAAACA	0.433													5	34					0	0	0	0	G	158617419	G	G	158617419	3	3	137	1	0	0	0	0	1	0	0	0	220	864	30	2	304	2	ACVR1	2	158617419	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	22037803	158617419	84581954	35	24590											
BAZ2B	29994	broad.mit.edu	37	chr2	160245956	160245956	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttacgctctttatttaatCttttctcatcacgtttttct	6	23	3	9	2	5	0	2	0	4	0	6	0	5	0	0	0	1	3	0	0	3	10			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:160245956C>G	uc002uao.2	-	21	3468	c.3116G>C	c.(3115-3117)AGA>ACA	p.R1039T	BAZ2B_uc002uap.2_Missense_Mutation_p.R1003T	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1039	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TTTATTTAATCTTTTCTCATC	0.323													23	56					0	0	0	0	G	160245956	G	G	160245956	3	3	137	1	0	0	0	0	1	0	0	0	1334	913	32	2	3458	2	BAZ2B	2	160245956	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	1628537	160245956	82953417	36	24591											
TTN	7273	broad.mit.edu	37	chr2	179579947	179579947	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtgaacatcagctccttTcagtgtctctataggatgag	11	12	10	8	0	3	2	2	2	1	0	5	3	4	3	1	2	2	1	1	2	4	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:179579947T>C	uc010zfg.1	-	87	22458	c.22234A>G	c.(22234-22236)AAA>GAA	p.K7412E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K4073E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8339							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGCTCCTTTCAGTGTCTCT	0.398													40	92					0	0	0	0	C	179579947	C	C	179579947	3	2	137	1	0	0	0	0	1	0	0	0	16803	1792	62	5	78655	5	TTN	2	179579947	Missense_Mutation	SNP	T	TCGA-CR-7365-01A-11D-2012-08	19333991	179579947	63619426	37	24592											
ANKAR	150709	broad.mit.edu	37	chr2	190571721	190571721	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagcactggacactattcaAtacctgttttctatcggtgc	9	13	9	10	1	2	0	1	0	1	0	3	2	2	2	1	3	3	2	1	3	4	6			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:190571721A>G	uc002uqw.1	+	8	1755	c.1755A>G	c.(1753-1755)CAA>CAG	p.Q585Q	ANKAR_uc002uqu.2_RNA	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	656	ANK 4.					integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			ACACTATTCAATACCTGTTTT	0.353													10	66					0	0	0	0	G	190571721	G	G	190571721	2	3	137	1	0	0	0	0	0	0	0	1	623	98	4	5		5	ANKAR	2	190571721	Silent	SNP	A	TCGA-CR-7365-01A-11D-2012-08	10991774	190571721	52627652	38	24593											
OSGEPL1	64172	broad.mit.edu	37	chr2	190617430	190617430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaaatgcccaagccagcaCgtagtctttcaataccattc	13	10	6	12	1	2	0	1	0	1	0	3	0	2	0	3	0	4	3	3	0	6	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:190617430C>T	uc002uqz.1	-	7	1649	c.1115G>A	c.(1114-1116)CGT>CAT	p.R372H	OSGEPL1_uc002ura.1_Intron	NM_022353	NP_071748	Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	372					proteolysis|tRNA processing		metalloendopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			CAAGCCAGCACGTAGTCTTTC	0.343													28	59					0	0	0	0	T	190617430	T	T	190617430	3	4	137	1	0	0	0	0	1	0	0	0	11342	536	19	1	137	1	OSGEPL1	2	190617430	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	45709	190617430	52581943	39	24594											
ALS2CR8	79800	broad.mit.edu	37	chr2	203834680	203834680	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagaagtttcctgaatataGagttcctacagaccccaaaa	16	9	6	10	0	0	4	0	1	0	3	2	4	2	4	4	0	1	2	4	0	7	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:203834680G>C	uc002uzo.2	+	10	1272	c.992G>C	c.(991-993)AGA>ACA	p.R331T	ALS2CR8_uc010zhz.1_RNA|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.R255T|ALS2CR8_uc010zib.1_Missense_Mutation_p.R255T|ALS2CR8_uc010zic.1_Missense_Mutation_p.R243T|ALS2CR8_uc002uzp.2_Missense_Mutation_p.R331T	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	331										large_intestine(1)|ovary(1)	2						CCTGAATATAGAGTTCCTACA	0.308													15	22					0	0	0	0	C	203834680	C	C	203834680	3	2	137	1	0	0	0	0	1	0	0	0	555	942	33	2	1022	2	ALS2CR8	2	203834680	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	13217250	203834680	39364693	40	24595											
ABCA12	26154	broad.mit.edu	37	chr2	215797408	215797408	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacacttatagtggaaccttGgctgctggtatcagcagttt	10	13	10	8	0	1	0	1	0	0	0	1	1	1	1	1	3	4	5	1	3	5	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:215797408G>C	uc002vew.2	-	53	7958	c.7738C>G	c.(7738-7740)CAA>GAA	p.Q2580E	ABCA12_uc002vev.2_Missense_Mutation_p.Q2262E|ABCA12_uc010zjn.1_Missense_Mutation_p.Q1507E	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2580					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GTGGAACCTTGGCTGCTGGTA	0.423													14	42					0	0	0	0	C	215797408	C	C	215797408	3	2	137	1	0	0	0	0	1	0	0	0	30	1357	47	4	53	4	ABCA12	2	215797408	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	11962728	215797408	27401965	41	24596											
C3orf15	89876	broad.mit.edu	37	chr3	119462951	119462951	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcctttgtcatgctggctGagcgccagcggcgggtacga	6	9	15	11	4	1	1	1	1	0	0	1	2	1	1	2	3	5	3	2	3	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr3:119462951G>A	uc003ede.3	+	14	1887	c.1810G>A	c.(1810-1812)GAG>AAG	p.E604K	C3orf15_uc010hqz.2_Missense_Mutation_p.E542K|C3orf15_uc011bjd.1_Missense_Mutation_p.E478K|C3orf15_uc011bje.1_Missense_Mutation_p.E584K	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	440						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		CATGCTGGCTGAGCGCCAGCG	0.572													33	78					0	0	0	0	A	119462951	A	A	119462951	3	1	137	1	0	0	0	0	1	0	0	0	2219	1291	45	2	1864	2	C3orf15	3	119462951	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08		119462951	78559479	42	24597											
KALRN	8997	broad.mit.edu	37	chr3	124398320	124398320	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaaggagacgaacagttccGaggaatcagagtgtgatgat	14	8	13	6	2	2	4	2	2	0	2	3	8	3	5	1	2	1	1	1	2	3	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr3:124398320G>A	uc003ehg.2	+	51	7460	c.7333G>A	c.(7333-7335)GAG>AAG	p.E2445K	KALRN_uc003ehk.2_Missense_Mutation_p.E748K	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2444					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GAACAGTTCCGAGGAATCAGA	0.428													38	122					0	0	0	0	A	124398320	A	A	124398320	3	1	137	1	0	0	0	0	1	0	0	0	8014	1059	37	1	7691	1	KALRN	3	124398320	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	4935369	124398320	73624110	43	24598											
HLTF	6596	broad.mit.edu	37	chr3	148781271	148781271	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaaacttactcttctccttGatatctgaaatactgggttg	10	15	7	9	1	3	2	0	2	3	0	4	3	3	2	1	1	3	1	1	1	5	6			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr3:148781271G>C	uc003ewq.1	-	10	1325	c.1107C>G	c.(1105-1107)ATC>ATG	p.I369M	HLTF_uc003ewr.1_Missense_Mutation_p.I369M|HLTF_uc003ews.1_Missense_Mutation_p.I369M|HLTF_uc010hve.1_Missense_Mutation_p.I369M	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	369					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TCTTCTCCTTGATATCTGAAA	0.333													25	61					0	0	0	0	C	148781271	C	C	148781271	3	2	137	1	0	0	0	0	1	0	0	0	7254	1280	45	2	1986	2	HLTF	3	148781271	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	24382951	148781271	49241159	44	24599											
TNIK	23043	broad.mit.edu	37	chr3	170786641	170786641	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttctgagtacttacatgaGatggtatgtagatatcataa	14	14	8	5	0	2	3	1	2	1	2	2	4	2	3	0	1	2	3	0	1	6	7			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr3:170786641G>T	uc003fhh.2	-	30	4040	c.3695C>A	c.(3694-3696)TCT>TAT	p.S1232Y	TNIK_uc003fhi.2_Missense_Mutation_p.S1177Y|TNIK_uc003fhj.2_Missense_Mutation_p.S1203Y|TNIK_uc003fhk.2_Missense_Mutation_p.S1224Y|TNIK_uc003fhl.2_Missense_Mutation_p.S1148Y|TNIK_uc003fhm.2_Missense_Mutation_p.S1169Y|TNIK_uc003fhn.2_Missense_Mutation_p.S1195Y|TNIK_uc003fho.2_Missense_Mutation_p.S1140Y|TNIK_uc003fhg.2_Missense_Mutation_p.S410Y|TNIK_uc003fhp.2_Missense_Mutation_p.S164Y	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1232	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			ACTTACATGAGATGGTATGTA	0.363													8	46					0.000157383	0.000163462	1	0	T	170786641	T	T	170786641	3	4	137	1	0	0	0	0	1	0	0	0	16379	942	33	2	403	2	TNIK	3	170786641	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	22005370	170786641	27235789	45	24600											
GRK4	2868	broad.mit.edu	37	chr4	3021418	3021418	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgccttgtgcttggtgctCaccattatgaatggagggga	8	12	14	7	0	1	1	1	1	0	0	1	4	1	3	2	4	3	2	2	4	2	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:3021418C>T	uc003ggn.1	+	9	1247	c.792C>T	c.(790-792)CTC>CTT	p.L264L	GRK4_uc003ggo.1_Silent_p.L264L|GRK4_uc003ggp.1_Silent_p.L232L|GRK4_uc003ggq.1_Silent_p.L232L	NM_182982	NP_892027	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4 isoform	264	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCTTGGTGCTCACCATTATGA	0.433													44	60					0	0	0	0	T	3021418	T	T	3021418	2	4	137	1	0	0	0	0	0	0	0	1	6830	813	29	2		2	GRK4	4	3021418	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08		3021418	188132858	46	24601											
STX18	53407	broad.mit.edu	37	chr4	4458949	4458949	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atccaccactcttttaactcGgatggctctctgttctgagt	7	15	7	12	1	3	1	0	1	3	0	6	2	4	2	2	2	1	2	2	2	1	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:4458949G>T	uc003gic.2	-	5	550	c.466C>A	c.(466-468)CGA>AGA	p.R156R		NM_016930	NP_058626	Q9P2W9	STX18_HUMAN	syntaxin 18	156	Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|intracellular protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	SNAP receptor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.0534)		CTTTTAACTCGGATGGCTCTC	0.343													7	26					3.09899e-07	3.31838e-07	1	0	T	4458949	T	T	4458949	2	4	137	1	0	0	0	0	0	0	0	1	15407	1124	39	3		3	STX18	4	4458949	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	1437531	4458949	186695327	47	24602											
BOD1L	259282	broad.mit.edu	37	chr4	13601055	13601055	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctaagccccttcctgctGaataacttgctgtgctactg	7	13	7	14	0	1	1	0	1	1	0	2	1	2	1	4	0	6	3	4	0	4	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:13601055G>T	uc003gmz.1	-	10	7586	c.7469C>A	c.(7468-7470)TCA>TAA	p.S2490*	BOD1L_uc010idr.1_Nonsense_Mutation_p.S1827*	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2490							DNA binding			ovary(5)|breast(1)	6						CCTTCCTGCTGAATAACTTGC	0.507											OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	49					1.61879e-10	1.77261e-10	1	0	T	13601055	T	T	13601055	4	4	137	1	0	0	0	0	0	1	0	0	1486	1294	45	2	1754	2	BOD1L	4	13601055	Nonsense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	9142106	13601055	177553221	48	24603											
NCAPG	64151	broad.mit.edu	37	chr4	17841312	17841313	+	Frame_Shift_Ins	INS	-	T	T																															ttttaggccttaacagtacaINStgacaatttggctatgaaaa																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:17841312_17841313insT	uc003gpp.2	+	17	2656_2657	c.2480_2481insT	c.(2479-2481)CATfs	p.H827fs	NCAPG_uc011bxj.1_Frame_Shift_Ins_p.H336fs	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	827					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		TTAACAGTACATGACAATTTGG	0.312													---	---	---								T	17841313	T	T	17841312	7	5	137	1	0	1	1	0	0	0	0	0	10261	217	8	0	2546	0	NCAPG	4	17841312	Frame_Shift_Ins	INS	-	TCGA-CR-7365-01A-11D-2012-08	4240257	17841312	173312964	49	24604											
UGT2A1	10941	broad.mit.edu	37	chr4	70512979	70512979	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgttggtttttaagaacGccatcacagatctcctgaga	11	12	9	9	1	2	3	1	1	1	3	3	4	2	3	2	1	2	3	2	1	2	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:70512979G>A	uc003hem.3	-	1	447	c.384C>T	c.(382-384)GGC>GGT	p.G128G	UGT2A1_uc011caq.1_Silent_p.G128G|UGT2A1_uc010ihu.2_Silent_p.G128G|UGT2A1_uc010iht.2_Silent_p.G128G	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	128	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						TTTTAAGAACGCCATCACAGA	0.418													19	36					0	0	0	0	A	70512979	A	A	70512979	2	1	137	1	0	0	0	0	0	0	0	1	17021	1074	38	1		1	UGT2A1	4	70512979	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	52671667	70512979	120641297	50	24605											
CNOT6L	246175	broad.mit.edu	37	chr4	78641757	78641757	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccccaggacaccaagcacgTtcatatgagtcttggaatag	12	8	10	11	1	2	1	1	1	1	0	2	3	2	3	3	2	1	2	3	2	4	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:78641757T>A	uc011ccd.1	-	12	1627	c.1496A>T	c.(1495-1497)AAC>ATC	p.N499I	CNOT6L_uc003hks.2_Missense_Mutation_p.N499I	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	499					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						ACCAAGCACGTTCATATGAGT	0.428													40	131					0	0	0	0	A	78641757	A	A	78641757	3	1	137	1	0	0	0	0	1	0	0	0	3638	1725	60	5	175	5	CNOT6L	4	78641757	Missense_Mutation	SNP	T	TCGA-CR-7365-01A-11D-2012-08	8128778	78641757	112512519	51	24606											
EGF	1950	broad.mit.edu	37	chr4	110866313	110866313	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaatttggatagccaacaaAcacactggaaaggacatggt	17	7	9	8	0	0	0	0	0	0	0	0	3	0	3	1	4	3	0	1	4	5	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:110866313A>G	uc003hzy.3	+	5	1274	c.822A>G	c.(820-822)AAA>AAG	p.K274K	EGF_uc011cfu.1_Silent_p.K274K|EGF_uc011cfv.1_Silent_p.K274K	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	274	Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TAGCCAACAAACACACTGGAA	0.398													7	23					0	0	0	0	G	110866313	G	G	110866313	2	3	137	1	0	0	0	0	0	0	0	1	4984	40	2	5		5	EGF	4	110866313	Silent	SNP	A	TCGA-CR-7365-01A-11D-2012-08	32224556	110866313	80287963	52	24607											
PET112L	5188	broad.mit.edu	37	chr4	152593929	152593930	+	Frame_Shift_Ins	INS	-	T	T																															tcaccacttgaggatgggccINStccatcacagagtggcagag																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:152593929_152593930insT	uc003iml.2	-	12	1541_1542	c.1529_1530insA	c.(1528-1530)GAGfs	p.E510fs	PET112L_uc003imk.2_RNA	NM_004564	NP_004555	O75879	GATB_HUMAN	PET112-like precursor	510						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding				0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)			L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAGGATGGGCCTCCATCACAGA	0.609													---	---	---								T	152593930	T	T	152593929	7	5	137	1	0	1	1	0	0	0	0	0	11788	680	24	0	151	0	PET112L	4	152593929	Frame_Shift_Ins	INS	-	TCGA-CR-7365-01A-11D-2012-08	41727616	152593929	38560347	53	24608											
DCHS2	54798	broad.mit.edu	37	chr4	155161884	155161884	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagcaaacttggttccaggAttactctctttggcaaaact	12	13	7	9	0	1	0	0	0	1	0	3	1	2	1	1	3	4	3	1	3	5	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:155161884A>G	uc003inw.2	-	23	5799	c.5799T>C	c.(5797-5799)AAT>AAC	p.N1933N		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1933	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGTTCCAGGATTACTCTCTT	0.383													16	55					0	0	0	0	G	155161884	G	G	155161884	2	3	137	1	0	0	0	0	0	0	0	1	4305	330	12	5		5	DCHS2	4	155161884	Silent	SNP	A	TCGA-CR-7365-01A-11D-2012-08	2567955	155161884	35992392	54	24609											
AHRR	57491	broad.mit.edu	37	chr5	422960	422960	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtgtttgggcagcccccGcccttggagacaggtgggtg	4	9	18	10	1	0	1	0	0	0	1	0	2	0	1	3	5	1	2	3	5	0	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:422960G>A	uc003jav.2	+	6	614	c.570G>A	c.(568-570)CCG>CCA	p.P190P	AHRR_uc003jaw.2_Silent_p.P186P|AHRR_uc010isy.2_Silent_p.P36P|AHRR_uc010isz.2_Silent_p.P186P|AHRR_uc003jax.2_Intron|AHRR_uc003jay.2_Silent_p.P46P	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GGCAGCCCCCGCCCTTGGAGA	0.592													6	47					0	0	0	0	A	422960	A	A	422960	2	1	137	1	0	0	0	0	0	0	0	1	417	1074	38	1		1	AHRR	5	422960	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08		422960	180492300	55	24610											
SPEF2	79925	broad.mit.edu	37	chr5	35692806	35692806	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgctctaccagttctgcaaGaggagattaaagaaagccag	15	8	10	8	0	2	3	0	0	2	3	2	4	2	3	2	1	4	3	2	1	5	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:35692806G>A	uc003jjo.2	+	12	1990	c.1879G>A	c.(1879-1881)GAG>AAG	p.E627K	SPEF2_uc003jjq.3_Missense_Mutation_p.E627K|SPEF2_uc003jjp.1_Missense_Mutation_p.E118K	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	627					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTTCTGCAAGAGGAGATTAA	0.393													21	41					0	0	0	0	A	35692806	A	A	35692806	3	1	137	1	0	0	0	0	1	0	0	0	15101	943	33	2	1946	2	SPEF2	5	35692806	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	35269846	35692806	145222454	56	24611											
VCAN	1462	broad.mit.edu	37	chr5	82834175	82834175	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caccaacacagtctgaaaggGaaatgacagattctactcct	15	8	7	11	0	2	3	0	2	2	1	3	4	3	4	2	1	2	0	2	1	4	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:82834175G>T	uc003kii.3	+	8	5709	c.5353G>T	c.(5353-5355)GAA>TAA	p.E1785*	VCAN_uc003kij.3_Nonsense_Mutation_p.E798*|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Nonsense_Mutation_p.E449*	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1785	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GTCTGAAAGGGAAATGACAGA	0.403													27	24					2.24059e-21	2.55766e-21	1	0	T	82834175	T	T	82834175	4	4	137	1	0	0	0	0	0	1	0	0	17206	1175	41	2	5379	2	VCAN	5	82834175	Nonsense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	47141369	82834175	98081085	57	24612											
RASA1	5921	broad.mit.edu	37	chr5	86675622	86675622	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacctattgaacatactttCagagcttgtggagaaaatat	15	12	7	7	0	1	3	1	1	0	2	1	4	1	3	1	1	3	1	1	1	6	6			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:86675622C>G	uc003kiw.2	+	19	2676	c.2558C>G	c.(2557-2559)TCA>TGA	p.S853*	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Nonsense_Mutation_p.S676*|RASA1_uc011ctv.1_Nonsense_Mutation_p.S686*|RASA1_uc011ctw.1_Nonsense_Mutation_p.S687*|RASA1_uc010jaw.2_Nonsense_Mutation_p.S675*	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	853	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		AACATACTTTCAGAGCTTGTG	0.303													14	17					0	0	0	0	G	86675622	G	G	86675622	4	3	137	1	0	0	0	0	0	1	0	0	13125	838	29	2	2644	2	RASA1	5	86675622	Nonsense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	3841447	86675622	94239638	58	24613											
ADAMTS19	171019	broad.mit.edu	37	chr5	128984583	128984583	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcaggtttgcctggattcaGagactggcaatgtcaggctt	8	12	13	8	0	2	1	2	0	0	1	2	3	2	2	1	4	2	4	1	4	1	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:128984583G>C	uc003kvb.1	+	13	2078	c.2078G>C	c.(2077-2079)AGA>ACA	p.R693T	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	693	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CCTGGATTCAGAGACTGGCAA	0.448													48	44					0	0	0	0	C	128984583	C	C	128984583	3	2	137	1	0	0	0	0	1	0	0	0	264	942	33	2	2128	2	ADAMTS19	5	128984583	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	42308961	128984583	51930677	59	24614											
PCDHB9	56127	broad.mit.edu	37	chr5	140568765	140568765	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcgcacaatggggaggtgcGcaccgccaggctgctgagcg	7	4	18	12	4	0	1	0	1	0	0	0	2	0	2	2	5	3	4	2	5	1	0			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:140568765G>A	uc003liw.1	+	3	1874	c.1874G>A	c.(1873-1875)CGC>CAC	p.R625H		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	625	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGGAGGTGCGCACCGCCAGG	0.692													35	36					0	0	0	0	A	140568765	A	A	140568765	3	1	137	1	0	0	0	0	1	0	0	0	11603	1087	38	1	1875	1	PCDHB9	5	140568765	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	11584182	140568765	40346495	60	24615											
RNF14	9604	broad.mit.edu	37	chr5	141358012	141358012	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgagctcaagattggttctCagaaaaaagtgcagagaagg	15	9	12	5	0	2	4	2	1	1	3	3	5	2	4	0	2	2	3	0	2	5	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:141358012C>T	uc003lly.2	+	4	490	c.451C>T	c.(451-453)CAG>TAG	p.Q151*	RNF14_uc003llz.2_Nonsense_Mutation_p.Q151*|RNF14_uc003lma.2_Nonsense_Mutation_p.Q151*|RNF14_uc003lmb.2_Nonsense_Mutation_p.Q25*|RNF14_uc003lmc.2_Nonsense_Mutation_p.Q151*|RNF14_uc011dbg.1_Intron|RNF14_uc011dbh.1_Intron|RNF14_uc003lmd.2_Nonsense_Mutation_p.Q151*	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	151					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GATTGGTTCTCAGAAAAAAGT	0.463													11	11					0	0	0	0	T	141358012	T	T	141358012	4	4	137	1	0	0	0	0	0	1	0	0	13508	827	29	2	461	2	RNF14	5	141358012	Nonsense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	789247	141358012	39557248	61	24616											
RNF14	9604	broad.mit.edu	37	chr5	141358039	141358039	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtgcagagaaggacagctCaagcttctcccaacacagag	15	5	10	11	0	2	2	1	0	1	2	3	4	2	3	1	1	4	3	1	1	4	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:141358039C>G	uc003lly.2	+	4	517	c.478C>G	c.(478-480)CAA>GAA	p.Q160E	RNF14_uc003llz.2_Missense_Mutation_p.Q160E|RNF14_uc003lma.2_Missense_Mutation_p.Q160E|RNF14_uc003lmb.2_Missense_Mutation_p.Q34E|RNF14_uc003lmc.2_Missense_Mutation_p.Q160E|RNF14_uc011dbg.1_Intron|RNF14_uc011dbh.1_Intron|RNF14_uc003lmd.2_Missense_Mutation_p.Q160E	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	160					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		AAGGACAGCTCAAGCTTCTCC	0.443													6	15					0	0	0	0	G	141358039	G	G	141358039	3	3	137	1	0	0	0	0	1	0	0	0	13508	827	29	2	488	2	RNF14	5	141358039	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	27	141358039	39557221	62	24617											
HIST1H2BB	3018	broad.mit.edu	37	chr6	26043802	26043802	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcggctgcgcttacgcttCttaccatccttcttctgcgc	3	15	8	15	4	3	0	0	0	3	0	4	0	4	0	2	1	5	3	2	1	2	6			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:26043802C>G	uc003nfu.2	-	1	84	c.84G>C	c.(82-84)AAG>AAC	p.K28N	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	28					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCTTACGCTTCTTACCATCCT	0.507													38	117					0	0	0	0	G	26043802	G	G	26043802	3	3	137	1	0	0	0	0	1	0	0	0	7180	912	32	2	300	2	HIST1H2BB	6	26043802	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08		26043802	145071265	63	24618											
HIST1H3D	8351	broad.mit.edu	37	chr6	26197074	26197074	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attcacaagacaatttacgcCctctccccacgaatgcggcg	11	8	7	15	4	2	1	1	0	1	1	3	2	2	1	3	1	2	0	3	1	4	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:26197074C>A	uc003ngv.2	-	2	802	c.405G>T	c.(403-405)AGG>AGT	p.R135S	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	135				Missing (in Ref. 2; AAA52651).	blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				CAATTTACGCCCTCTCCCCAC	0.502													28	40					7.26314e-15	8.17526e-15	1	0	A	26197074	A	A	26197074	3	1	137	1	0	0	0	0	1	0	0	0	7197	622	22	4	9	4	HIST1H3D	6	26197074	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	153272	26197074	144917993	64	24619											
DDR1	780	broad.mit.edu	37	chr6	30859860	30859860	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagagtcaggagctgcgggtCtggccaggctatgactatgt	9	9	15	8	1	2	2	1	1	1	1	2	3	2	3	1	4	2	2	1	4	3	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:30859860C>G	uc003nrr.2	+	8	1006	c.747C>G	c.(745-747)GTC>GTG	p.V249V	DDR1_uc010jse.2_Silent_p.V249V|DDR1_uc003nrq.2_Silent_p.V249V|DDR1_uc003nrs.2_Silent_p.V249V|DDR1_uc003nrt.2_Silent_p.V249V|DDR1_uc011dms.1_Silent_p.V267V|DDR1_uc003nru.2_Silent_p.V249V|DDR1_uc011dmu.1_Missense_Mutation_p.S216C|DDR1_uc003nrv.2_Silent_p.V249V|DDR1_uc003nrw.1_Silent_p.V48V|DDR1_uc003nry.1_5'Flank|DDR1_uc003nrx.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	249	Extracellular (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	AGCTGCGGGTCTGGCCAGGCT	0.577													54	89					0	0	0	0	G	30859860	G	G	30859860	2	3	137	1	0	0	0	0	0	0	0	1	4353	900	32	2		2	DDR1	6	30859860	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	4662786	30859860	140255207	65	24620											
DDR1	780	broad.mit.edu	37	chr6	30860256	30860256	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcggccgtgtggctcgctttCtgcagtgccgcttcctcttt	1	14	12	14	4	2	0	0	0	2	0	4	0	3	0	3	2	2	4	3	2	0	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:30860256C>T	uc003nrr.2	+	9	1295	c.1036C>T	c.(1036-1038)CTG>TTG	p.L346L	DDR1_uc010jse.2_Silent_p.L346L|DDR1_uc003nrq.2_Silent_p.L346L|DDR1_uc003nrs.2_Silent_p.L346L|DDR1_uc003nrt.2_Silent_p.L346L|DDR1_uc011dms.1_Silent_p.L364L|DDR1_uc003nru.2_Silent_p.L346L|DDR1_uc003nrv.2_Silent_p.L346L|DDR1_uc003nrw.1_Silent_p.L145L|DDR1_uc003nry.1_5'Flank|DDR1_uc003nrx.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	346	Extracellular (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	GGCTCGCTTTCTGCAGTGCCG	0.637													35	33					0	0	0	0	T	30860256	T	T	30860256	2	4	137	1	0	0	0	0	0	0	0	1	4353	912	32	2		2	DDR1	6	30860256	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	396	30860256	140254811	66	24621											
DDR1	780	broad.mit.edu	37	chr6	30862324	30862324	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggagctgacggttcacctCtctgtccctggggacactat	7	10	12	12	1	2	1	1	1	1	0	4	4	3	3	2	4	1	2	2	4	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:30862324C>G	uc003nrr.2	+	12	1648	c.1389C>G	c.(1387-1389)CTC>CTG	p.L463L	DDR1_uc010jse.2_Silent_p.L463L|DDR1_uc003nrq.2_Silent_p.L463L|DDR1_uc003nrs.2_Silent_p.L463L|DDR1_uc003nrt.2_Silent_p.L463L|DDR1_uc011dms.1_Silent_p.L481L|DDR1_uc003nru.2_Silent_p.L463L|DDR1_uc003nrv.2_Silent_p.L463L|DDR1_uc003nrw.1_Intron|DDR1_uc003nry.1_RNA|DDR1_uc003nrx.1_Intron|DDR1_uc003nrz.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	463	Cytoplasmic (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	CGGTTCACCTCTCTGTCCCTG	0.587													46	52					0	0	0	0	G	30862324	G	G	30862324	2	3	137	1	0	0	0	0	0	0	0	1	4353	900	32	2		2	DDR1	6	30862324	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	2068	30862324	140252743	67	24622											
CCHCR1	54535	broad.mit.edu	37	chr6	31118878	31118878	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actggaaagagcctcctcgtGagcctgtgtcaaagaggaca	12	7	12	10	1	1	3	1	1	0	2	3	5	2	5	3	2	2	0	3	2	2	0			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:31118878G>C	uc003nsr.3	-	5	679	c.556C>G	c.(556-558)CAC>GAC	p.H186D	CCHCR1_uc011dne.1_Missense_Mutation_p.H186D|CCHCR1_uc003nsq.3_Missense_Mutation_p.H239D|CCHCR1_uc003nsp.3_Missense_Mutation_p.H275D|CCHCR1_uc010jsk.1_Missense_Mutation_p.H186D	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	186	Potential.				cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						GCCTCCTCGTGAGCCTGTGTC	0.572													41	146					0	0	0	0	C	31118878	C	C	31118878	3	2	137	1	0	0	0	0	1	0	0	0	2890	1290	45	2	1848	2	CCHCR1	6	31118878	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	256554	31118878	139996189	68	24623											
MOCS1	4337	broad.mit.edu	37	chr6	39874211	39874211	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaacacgatgtccctgctGacagccttgcacatgtcata	10	10	7	14	1	1	1	1	1	0	0	3	2	3	1	3	0	4	2	3	0	2	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:39874211G>T	uc003opb.2	-	10	1971	c.1833C>A	c.(1831-1833)GTC>GTA	p.V611V	MOCS1_uc003opa.2_3'UTR|MOCS1_uc003opc.2_Silent_p.V595V|MOCS1_uc003opd.2_3'UTR|MOCS1_uc003ope.2_Silent_p.V508V	NM_005942	NP_005933	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis-step 1 protein	611	Molybdenum cofactor biosynthesis protein C.				Mo-molybdopterin cofactor biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			ovary(1)|liver(1)|central_nervous_system(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					TGTCCCTGCTGACAGCCTTGC	0.627													72	96					3.61411e-23	4.16483e-23	1	0	T	39874211	T	T	39874211	2	4	137	1	0	0	0	0	0	0	0	1	9743	1305	45	2		2	MOCS1	6	39874211	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	8755333	39874211	131240856	69	24624											
CUL7	9820	broad.mit.edu	37	chr6	43007895	43007895	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctgcctggctgctcactCttgttgtagaagttggagta	6	14	11	10	0	3	1	1	0	2	1	3	2	3	2	2	2	2	6	2	2	3	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:43007895C>G	uc003otq.2	-	22	4596	c.4293G>C	c.(4291-4293)AAG>AAC	p.K1431N	CUL7_uc010jyg.2_Missense_Mutation_p.K710N|CUL7_uc011dvb.1_Missense_Mutation_p.K1515N|CUL7_uc010jyh.2_Missense_Mutation_p.K424N|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1431					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GCTGCTCACTCTTGTTGTAGA	0.592													23	112					0	0	0	0	G	43007895	G	G	43007895	3	3	137	1	0	0	0	0	1	0	0	0	4077	927	32	2	823	2	CUL7	6	43007895	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	3133684	43007895	128107172	70	24625											
CUL7	9820	broad.mit.edu	37	chr6	43008291	43008291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tattttcttctctgtatcctCcagcttcaggagttcctgat	6	18	6	11	0	3	1	1	1	2	0	7	2	6	2	3	1	1	3	3	1	2	7			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:43008291C>T	uc003otq.2	-	21	4303	c.4000G>A	c.(4000-4002)GAG>AAG	p.E1334K	CUL7_uc010jyg.2_Missense_Mutation_p.E613K|CUL7_uc011dvb.1_Missense_Mutation_p.E1418K|CUL7_uc010jyh.2_Missense_Mutation_p.E327K|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1334					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TCTGTATCCTCCAGCTTCAGG	0.567													57	187					0	0	0	0	T	43008291	T	T	43008291	3	4	137	1	0	0	0	0	1	0	0	0	4077	864	30	2	1120	2	CUL7	6	43008291	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	396	43008291	128106776	71	24626											
SPATS1	221409	broad.mit.edu	37	chr6	44337822	44337822	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agaaatttgatacatttattCcacttgagcctcttccacaa	13	14	4	10	0	1	3	0	2	1	1	3	3	3	3	3	0	2	0	3	0	4	7			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:44337822C>G	uc003oxk.2	+	6	1077	c.730C>G	c.(730-732)CCA>GCA	p.P244A	SPATS1_uc003oxg.2_RNA|SPATS1_uc010jzb.2_Missense_Mutation_p.P129A	NM_145026	NP_659463	Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	244										skin(1)	1	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TACATTTATTCCACTTGAGCC	0.323													42	54					0	0	0	0	G	44337822	G	G	44337822	3	3	137	1	0	0	0	0	1	0	0	0	15084	855	30	2	752	2	SPATS1	6	44337822	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	1329531	44337822	126777245	72	24627											
DST	667	broad.mit.edu	37	chr6	56338733	56338733	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaggaaggatcagcagctCtcctcttataggtcttcgtt	9	13	10	9	1	4	1	1	1	3	0	6	3	4	3	1	3	2	3	1	3	3	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:56338733C>T	uc003pdf.2	-	87	15603	c.15575G>A	c.(15574-15576)AGA>AAA	p.R5192K	DST_uc003pcz.3_Missense_Mutation_p.R5014K|DST_uc011dxj.1_Missense_Mutation_p.R5043K|DST_uc011dxk.1_Missense_Mutation_p.R5054K|DST_uc003pcy.3_Missense_Mutation_p.R4688K	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7100					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATCAGCAGCTCTCCTCTTATA	0.373													11	5					0	0	0	0	T	56338733	T	T	56338733	3	4	137	1	0	0	0	0	1	0	0	0	4805	913	32	2	1496	2	DST	6	56338733	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	12000911	56338733	114776334	73	24628											
DDX43	55510	broad.mit.edu	37	chr6	74114465	74114466	+	Frame_Shift_Ins	INS	-	A	A																															agtccactgccacaagtgccINSatgtcaaaagtagaagcaga																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:74114465_74114466insA	uc003pgw.2	+	5	965_966	c.621_622insA	c.(619-624)GCCATGfs	p.A207fs	DDX43_uc011dyn.1_Intron	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	207_208						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						CCACAAGTGCCATGTCAAAAGT	0.361													---	---	---								A	74114466	A	A	74114465	7	5	137	1	0	1	1	0	0	0	0	0	4380	581	21	0	639	0	DDX43	6	74114465	Frame_Shift_Ins	INS	-	TCGA-CR-7365-01A-11D-2012-08	17775732	74114465	97000602	74	24629											
ZUFSP	221302	broad.mit.edu	37	chr6	116968707	116968707	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaagaataatagttcaatatCcattcaaataagcgagggtg	17	10	9	5	1	2	1	2	0	0	1	3	3	3	1	1	1	1	1	1	1	8	6			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:116968707C>G	uc003pxf.1	-	8	1629	c.1383G>C	c.(1381-1383)TGG>TGC	p.W461C	ZUFSP_uc010kef.1_Missense_Mutation_p.W265C	NM_145062	NP_659499	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	461						intracellular	zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		AGTTCAATATCCATTCAAATA	0.353													21	54					0	0	0	0	G	116968707	G	G	116968707	3	3	137	1	0	0	0	0	1	0	0	0	18313	856	30	2	365	2	ZUFSP	6	116968707	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	42854242	116968707	54146360	75	24630											
PLEKHG1	57480	broad.mit.edu	37	chr6	151161325	151161325	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgcagcgtggtagtaagtCagcccaacaaagagaactgg	14	6	13	8	1	1	1	1	0	0	1	1	3	1	1	1	2	5	3	1	2	5	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:151161325C>T	uc003qny.1	+	17	3763	c.3451C>T	c.(3451-3453)CAG>TAG	p.Q1151*	PLEKHG1_uc011eem.1_Nonsense_Mutation_p.Q1210*	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	1151					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GGTAGTAAGTCAGCCCAACAA	0.522													25	114					0	0	0	0	T	151161325	T	T	151161325	4	4	137	1	0	0	0	0	0	1	0	0	12123	827	29	2	3509	2	PLEKHG1	6	151161325	Nonsense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	34192618	151161325	19953742	76	24631											
SERAC1	84947	broad.mit.edu	37	chr6	158535902	158535902	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagccaaacgtgatccatGatgagggacactataaaaaa	17	8	8	8	1	1	3	1	3	0	0	2	4	2	4	2	1	2	0	2	1	5	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:158535902G>A	uc003qrc.2	-	15	1745	c.1603C>T	c.(1603-1605)CAT>TAT	p.H535Y	SERAC1_uc003qrb.2_Missense_Mutation_p.H263Y	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	535					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		CGTGATCCATGATGAGGGACA	0.383													62	110					0	0	0	0	A	158535902	A	A	158535902	3	1	137	1	0	0	0	0	1	0	0	0	14139	1290	45	2	373	2	SERAC1	6	158535902	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	7374577	158535902	12579165	77	24632											
TTLL2	83887	broad.mit.edu	37	chr6	167753771	167753771	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaacctgtactggaggacatCctctttccgaatgaccgaac	11	9	9	12	2	1	1	0	1	1	0	3	6	3	3	4	2	3	1	4	2	4	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:167753771C>T	uc003qvs.1	+	3	471	c.383C>T	c.(382-384)TCC>TTC	p.S128F	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	128	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TGGAGGACATCCTCTTTCCGA	0.537													5	24					0	0	0	0	T	167753771	T	T	167753771	3	4	137	1	0	0	0	0	1	0	0	0	16795	855	30	2	393	2	TTLL2	6	167753771	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	9217869	167753771	3361296	78	24633											
DNAH11	8701	broad.mit.edu	37	chr7	21847506	21847506	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatctttcagtcagagaagAttcgctggggtcaatccatt	10	13	9	9	1	5	2	4	0	1	2	7	3	6	2	1	2	0	1	1	2	2	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:21847506A>G	uc003svc.2	+	64	10223	c.10192A>G	c.(10192-10194)ATT>GTT	p.I3398V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3398	Potential.|Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTCAGAGAAGATTCGCTGGGG	0.443									Kartagener_syndrome				15	14					0	0	0	0	G	21847506	G	G	21847506	3	3	137	1	0	0	0	0	1	0	0	0	4621	333	12	5	10443	5	DNAH11	7	21847506	Missense_Mutation	SNP	A	TCGA-CR-7365-01A-11D-2012-08		21847506	137291157	79	24634											
DFNA5	1687	broad.mit.edu	37	chr7	24784316	24784316	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagtgcagtctccagggttCcactcacgtggtttgcaaac	8	10	10	13	1	2	0	1	0	1	0	4	0	3	0	3	2	3	4	3	2	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:24784316C>A	uc010kus.1	-	3	357	c.269G>T	c.(268-270)GGA>GTA	p.G90V	DFNA5_uc003swz.2_5'UTR|DFNA5_uc003sxa.1_Missense_Mutation_p.G90V|DFNA5_uc010kut.1_5'UTR|DFNA5_uc003sxb.2_Missense_Mutation_p.G90V|DFNA5_uc003sxc.2_Missense_Mutation_p.G90V	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	90					sensory perception of sound					ovary(1)	1						CTCCAGGGTTCCACTCACGTG	0.562													50	48					7.89702e-26	9.14392e-26	1	0	A	24784316	A	A	24784316	3	1	137	1	0	0	0	0	1	0	0	0	4476	855	30	2	1253	2	DFNA5	7	24784316	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	2936810	24784316	134354347	80	24635											
CYCS	54205	broad.mit.edu	37	chr7	25163649	25163649	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aagagaccatggagatttggCccagtcttgtgcttgcctcc	8	11	11	11	0	1	2	0	0	1	2	2	4	2	2	4	2	2	1	4	2	1	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:25163649C>T	uc003sxl.2	-	2	235	c.90G>A	c.(88-90)GGG>GGA	p.G30G		NM_018947	NP_061820	P99999	CYC_HUMAN	cytochrome c	30					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis by intracellular signals|respiratory electron transport chain|transport	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nucleus|protein phosphatase type 2A complex|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding|protein binding			ovary(1)|lung(1)	2					Melatonin(DB01065)|Minocycline(DB01017)	GGAGATTTGGCCCAGTCTTGT	0.443													4	86					0	0	0	0	T	25163649	T	T	25163649	2	4	137	1	0	0	0	0	0	0	0	1	4153	726	26	4		4	CYCS	7	25163649	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	379333	25163649	133975014	81	24636											
POM121L12	285877	broad.mit.edu	37	chr7	53103452	53103453	+	Missense_Mutation	DNP	GC	AA	AA																															tgcaaggccccgacgccctgGcggctcccatgagcaggtca																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:53103452_53103453GC>AA	uc003tpz.2	+	1	104_105	c.88_89GC>AA	c.(88-90)GCG>AAG	p.A30K		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	30											0						CGACGCCCTGGCGGCTCCCATG	0.693													13	42					0	0	0	0	AA	53103453	AA	AA	53103452	3	1	137	1	0	0	0	0	1	0	0	0	12296	1203	42	4	90	4	POM121L12	7	53103452	Missense_Mutation	DNP	GC	TCGA-CR-7365-01A-11D-2012-08	27939803	53103452	106035211	82	24637											
POM121L12	285877	broad.mit.edu	37	chr7	53103987	53103987	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agacagcaagggtggcaggcGgaacctgcagccccggccct	9	3	15	14	2	0	1	0	0	0	1	0	2	0	2	4	5	4	3	4	5	2	0			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:53103987G>A	uc003tpz.2	+	1	639	c.623G>A	c.(622-624)CGG>CAG	p.R208Q		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	208											0						GGTGGCAGGCGGAACCTGCAG	0.667													42	59					0	0	0	0	A	53103987	A	A	53103987	3	1	137	1	0	0	0	0	1	0	0	0	12296	1116	39	1	625	1	POM121L12	7	53103987	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	535	53103987	106034676	83	24638											
MAGI2	9863	broad.mit.edu	37	chr7	78636436	78636436	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggaggtagaggttgtcacGaatgatttgctgaagctcat	10	11	14	6	2	2	3	2	2	0	1	2	5	2	4	0	3	2	4	0	3	3	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:78636436G>T	uc003ugx.2	-	2	642	c.388C>A	c.(388-390)CGT>AGT	p.R130S	MAGI2_uc003ugy.2_Missense_Mutation_p.R130S	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	130	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AGGTTGTCACGAATGATTTGC	0.363													27	34					4.87955e-14	5.41675e-14	1	0	T	78636436	T	T	78636436	3	4	137	1	0	0	0	0	1	0	0	0	9244	1058	37	3	4063	3	MAGI2	7	78636436	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	25532449	78636436	80502227	84	24639											
INTS10	55174	broad.mit.edu	37	chr8	19681434	19681434	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagcaaacgtagctctcagAagtacataatagaagggctg	15	8	10	8	1	1	2	1	0	1	2	2	2	1	2	0	1	4	5	0	1	8	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:19681434A>G	uc003wzj.2	+	7	846	c.715A>G	c.(715-717)AAG>GAG	p.K239E		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	239					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		TAGCTCTCAGAAGTACATAAT	0.398													24	50					0	0	0	0	G	19681434	G	G	19681434	3	3	137	1	0	0	0	0	1	0	0	0	7815	247	9	5	741	5	INTS10	8	19681434	Missense_Mutation	SNP	A	TCGA-CR-7365-01A-11D-2012-08		19681434	126682588	85	24640											
TRPA1	8989	broad.mit.edu	37	chr8	72958791	72958791	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atataacatcctgtgtaggtGtttttttggtgaattctaat	10	19	8	4	0	1	1	0	1	1	0	2	1	2	1	1	2	1	2	1	2	5	8			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:72958791G>T	uc003xza.2	-	17	2193	c.2018C>A	c.(2017-2019)ACA>AAA	p.T673K	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	673	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CTGTGTAGGTGTTTTTTTGGT	0.269													19	45					3.8784e-16	4.38586e-16	1	0	T	72958791	T	T	72958791	3	4	137	1	0	0	0	0	1	0	0	0	16644	1377	48	4	1385	4	TRPA1	8	72958791	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	53277357	72958791	73405231	86	24641			1	35		2	2	17	N	G_C	9.923053e-05
TRPA1	8989	broad.mit.edu	37	chr8	72958807	72958807	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtgtttttttggtgaattCtaatggacattgaagatatt	11	18	10	2	0	1	3	0	2	1	1	1	4	1	4	0	3	0	1	0	3	4	8			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:72958807C>G	uc003xza.2	-	17	2177	c.2002G>C	c.(2002-2004)GAA>CAA	p.E668Q	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	668	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TTGGTGAATTCTAATGGACAT	0.294													11	38					0	0	0	0	G	72958807	G	G	72958807	3	3	137	1	0	0	0	0	1	0	0	0	16644	922	32	2	1401	2	TRPA1	8	72958807	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	16	72958807	73405215	87	24642			1	35		2	2	17	N	G_C	9.923053e-05
FZD6	8323	broad.mit.edu	37	chr8	104343656	104343656	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttcagaaccaagcagcctCaaaggttccacatctctgct	11	10	6	14	0	4	1	2	0	2	1	6	1	5	1	3	1	4	3	3	1	3	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:104343656C>G	uc003ylh.2	+	7	2324	c.2040C>G	c.(2038-2040)CTC>CTG	p.L680L	FZD6_uc003ylj.2_Silent_p.L680L|FZD6_uc011lhn.1_Silent_p.L646L|FZD6_uc011lho.1_Silent_p.L375L|FZD6_uc011lhp.1_Silent_p.L625L	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	680	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			CAAGCAGCCTCAAAGGTTCCA	0.448													34	105					0	0	0	0	G	104343656	G	G	104343656	2	3	137	1	0	0	0	0	0	0	0	1	6168	813	29	2		2	FZD6	8	104343656	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	31384849	104343656	42020366	88	24643											
TRPS1	7227	broad.mit.edu	37	chr8	116631735	116631735	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggcacttgtgggttttttGaggccactgaaactgggctc	8	12	13	8	0	0	2	0	2	0	0	1	2	0	2	1	4	1	3	1	4	2	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:116631735G>C	uc003ynz.2	-	2	1010	c.551C>G	c.(550-552)TCA>TGA	p.S184*	TRPS1_uc011lhy.1_Nonsense_Mutation_p.S188*|TRPS1_uc003yny.2_Nonsense_Mutation_p.S197*|TRPS1_uc010mcy.2_Nonsense_Mutation_p.S184*	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	184					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TGGGTTTTTTGAGGCCACTGA	0.483									Langer-Giedion_syndrome				21	139					0	0	0	0	C	116631735	C	C	116631735	4	2	137	1	0	0	0	0	0	1	0	0	16660	1294	45	2	3314	2	TRPS1	8	116631735	Nonsense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	12288079	116631735	29732287	89	24644											
PHF20L1	51105	broad.mit.edu	37	chr8	133837598	133837598	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaagaagaaaaaaaagaaaAagaaatctaagcaacatggt	26	4	8	3	0	1	5	0	0	1	5	1	5	1	5	0	1	2	1	0	1	11	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:133837598A>G	uc003ytt.2	+	14	2051	c.1726A>G	c.(1726-1728)AAG>GAG	p.K576E	PHF20L1_uc011lja.1_Missense_Mutation_p.K550E|PHF20L1_uc003ytu.1_RNA	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	576	Lys-rich.						nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			aaaaaagaaaaagaaATCTAA	0.199													7	0					0	0	0	0	G	133837598	G	G	133837598	3	3	137	1	0	0	0	0	1	0	0	0	11887	15	1	5	1872	5	PHF20L1	8	133837598	Missense_Mutation	SNP	A	TCGA-CR-7365-01A-11D-2012-08	17205863	133837598	12526424	90	24645											
PLEC	5339	broad.mit.edu	37	chr8	144995066	144995066	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccaggctgcgcaggccctCaaagcaaagccggcccttct	9	5	10	17	2	2	0	1	0	1	0	2	0	2	0	4	3	3	3	4	3	2	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144995066C>G	uc003zaf.1	-	32	9504	c.9334G>C	c.(9334-9336)GAG>CAG	p.E3112Q	PLEC_uc003zab.1_Missense_Mutation_p.E2975Q|PLEC_uc003zac.1_Missense_Mutation_p.E2979Q|PLEC_uc003zad.2_Missense_Mutation_p.E2975Q|PLEC_uc003zae.1_Missense_Mutation_p.E2943Q|PLEC_uc003zag.1_Missense_Mutation_p.E2953Q|PLEC_uc003zah.2_Missense_Mutation_p.E2961Q|PLEC_uc003zaj.2_Missense_Mutation_p.E3002Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3112	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCAGGCCCTCAAAGCAAAGC	0.647													13	35					0	0	0	0	G	144995066	G	G	144995066	3	3	137	1	0	0	0	0	1	0	0	0	12107	835	29	2	4724	2	PLEC	8	144995066	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	11157468	144995066	1368956	91	24646			2	36	72036259	6	6	1330	C		3.125562e-13
PLEC	5339	broad.mit.edu	37	chr8	144995127	144995127	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgatgatgatcttgatgatCttctccactgtgatccggcc	7	14	10	10	1	3	6	0	6	3	0	5	6	4	6	3	1	0	0	3	1	0	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144995127C>G	uc003zaf.1	-	32	9443	c.9273G>C	c.(9271-9273)AAG>AAC	p.K3091N	PLEC_uc003zab.1_Missense_Mutation_p.K2954N|PLEC_uc003zac.1_Missense_Mutation_p.K2958N|PLEC_uc003zad.2_Missense_Mutation_p.K2954N|PLEC_uc003zae.1_Missense_Mutation_p.K2922N|PLEC_uc003zag.1_Missense_Mutation_p.K2932N|PLEC_uc003zah.2_Missense_Mutation_p.K2940N|PLEC_uc003zaj.2_Missense_Mutation_p.K2981N	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3091	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCTTGATGATCTTCTCCACTG	0.622													17	53					0	0	0	0	G	144995127	G	G	144995127	3	3	137	1	0	0	0	0	1	0	0	0	12107	912	32	2	4785	2	PLEC	8	144995127	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	61	144995127	1368895	92	24647			2	36	72036259	6	6	1330	C		3.125562e-13
PLEC	5339	broad.mit.edu	37	chr8	144995409	144995409	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgcaggtacgtgaggttCtcgtgcgtgttggggtcaaa	7	11	16	7	3	2	1	1	1	1	0	3	1	2	1	0	4	4	5	0	4	2	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144995409C>T	uc003zaf.1	-	32	9161	c.8991G>A	c.(8989-8991)GAG>GAA	p.E2997E	PLEC_uc003zab.1_Silent_p.E2860E|PLEC_uc003zac.1_Silent_p.E2864E|PLEC_uc003zad.2_Silent_p.E2860E|PLEC_uc003zae.1_Silent_p.E2828E|PLEC_uc003zag.1_Silent_p.E2838E|PLEC_uc003zah.2_Silent_p.E2846E|PLEC_uc003zaj.2_Silent_p.E2887E	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2997	Globular 2.|Plectin 5.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						ACGTGAGGTTCTCGTGCGTGT	0.657													31	128					0	0	0	0	T	144995409	T	T	144995409	2	4	137	1	0	0	0	0	0	0	0	1	12107	912	32	2		2	PLEC	8	144995409	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	282	144995409	1368613	93	24648			2	36	72036259	6	6	1330	C		3.125562e-13
PLEC	5339	broad.mit.edu	37	chr8	144996152	144996152	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcgaggcagtgacctcctCtgagtgcgccagcgcggccc	5	6	14	16	4	1	2	0	2	1	0	2	3	2	2	4	2	3	1	4	2	0	0			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144996152C>G	uc003zaf.1	-	32	8418	c.8248G>C	c.(8248-8250)GAG>CAG	p.E2750Q	PLEC_uc003zab.1_Missense_Mutation_p.E2613Q|PLEC_uc003zac.1_Missense_Mutation_p.E2617Q|PLEC_uc003zad.2_Missense_Mutation_p.E2613Q|PLEC_uc003zae.1_Missense_Mutation_p.E2581Q|PLEC_uc003zag.1_Missense_Mutation_p.E2591Q|PLEC_uc003zah.2_Missense_Mutation_p.E2599Q|PLEC_uc003zaj.2_Missense_Mutation_p.E2640Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2750	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTGACCTCCTCTGAGTGCGCC	0.632													4	45					0	0	0	0	G	144996152	G	G	144996152	3	3	137	1	0	0	0	0	1	0	0	0	12107	922	32	2	5810	2	PLEC	8	144996152	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	743	144996152	1367870	94	24649			2	36	72036259	6	6	1330	C		3.125562e-13
PLEC	5339	broad.mit.edu	37	chr8	144996219	144996219	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctcacgcagcctctggttCtcctcagccagcagctcctc	5	10	8	18	1	4	0	2	0	2	0	7	0	5	0	4	1	5	5	4	1	0	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144996219C>T	uc003zaf.1	-	32	8351	c.8181G>A	c.(8179-8181)GAG>GAA	p.E2727E	PLEC_uc003zab.1_Silent_p.E2590E|PLEC_uc003zac.1_Silent_p.E2594E|PLEC_uc003zad.2_Silent_p.E2590E|PLEC_uc003zae.1_Silent_p.E2558E|PLEC_uc003zag.1_Silent_p.E2568E|PLEC_uc003zah.2_Silent_p.E2576E|PLEC_uc003zaj.2_Silent_p.E2617E	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2727	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCTCTGGTTCTCCTCAGCCA	0.547													4	27					0	0	0	0	T	144996219	T	T	144996219	2	4	137	1	0	0	0	0	0	0	0	1	12107	912	32	2		2	PLEC	8	144996219	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	67	144996219	1367803	95	24650			2	36	72036259	6	6	1330	C		3.125562e-13
PLEC	5339	broad.mit.edu	37	chr8	144996395	144996395	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctgccgctgctgctcctCacgcagctgctgtgccttgg	2	11	12	16	2	1	0	1	0	0	0	2	0	2	0	3	1	7	7	3	1	0	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144996395C>T	uc003zaf.1	-	32	8175	c.8005G>A	c.(8005-8007)GAG>AAG	p.E2669K	PLEC_uc003zab.1_Missense_Mutation_p.E2532K|PLEC_uc003zac.1_Missense_Mutation_p.E2536K|PLEC_uc003zad.2_Missense_Mutation_p.E2532K|PLEC_uc003zae.1_Missense_Mutation_p.E2500K|PLEC_uc003zag.1_Missense_Mutation_p.E2510K|PLEC_uc003zah.2_Missense_Mutation_p.E2518K|PLEC_uc003zaj.2_Missense_Mutation_p.E2559K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2669	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						tgctgctCCTCACGCAGCTGC	0.517													9	8					0	0	0	0	T	144996395	T	T	144996395	3	4	137	1	0	0	0	0	1	0	0	0	12107	835	29	2	6053	2	PLEC	8	144996395	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	176	144996395	1367627	96	24651			2	36	72036259	6	6	1330	C		3.125562e-13
SLC39A4	55630	broad.mit.edu	37	chr8	145638738	145638738	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcgaagttgtgcacggcgtCgcccagagtgatcatatagg	9	8	15	9	4	1	2	1	1	0	1	2	3	1	2	1	3	1	2	1	3	3	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:145638738C>T	uc003zcq.2	-	10	1610	c.1510G>A	c.(1510-1512)GAC>AAC	p.D504N	SLC39A4_uc003zcm.1_Missense_Mutation_p.D6N|SLC39A4_uc003zcn.2_Missense_Mutation_p.D6N|SLC39A4_uc003zco.2_Missense_Mutation_p.D228N|SLC39A4_uc003zcp.2_Missense_Mutation_p.D479N	NM_130849	NP_570901	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter),	504	Cytoplasmic (Potential).					cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			TGCACGGCGTCGCCCAGAGTG	0.697													8	27					0	0	0	0	T	145638738	T	T	145638738	3	4	137	1	0	0	0	0	1	0	0	0	14684	884	31	1	445	1	SLC39A4	8	145638738	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	642343	145638738	725284	97	24652											
ACO1	48	broad.mit.edu	37	chr9	32448900	32448900	+	Frame_Shift_Del	DEL	A	-	-																															tctttattcatcagggaatcAaagccgtcctggccgagagc																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:32448900delA	uc003zqw.3	+	20	2532	c.2377delA	c.(2377-2379)AAAfs	p.K793fs	ACO1_uc003zqx.3_Frame_Shift_Del_p.K793fs|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	793					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TCAGGGAATCAAAGCCGTCCT	0.448													---	---	---								-	32448900	-	-	32448900	7	5	137	1	0	1	0	1	0	0	0	0	146	131	5	0	2451	0	ACO1	9	32448900	Frame_Shift_Del	DEL	A	TCGA-CR-7365-01A-11D-2012-08		32448900	108764531	98	24653											
DDX58	23586	broad.mit.edu	37	chr9	32493813	32493813	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattcagacagatcagaaatGatatcggttgggataattct	14	12	9	6	1	3	4	2	1	1	3	4	5	3	5	0	2	0	1	0	2	3	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:32493813G>A	uc003zra.2	-	3	527	c.369C>T	c.(367-369)ATC>ATT	p.I123I	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Silent_p.I78I|DDX58_uc011lnr.1_5'UTR|DDX58_uc010mji.2_Silent_p.I52I	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	123	CARD 2.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		GATCAGAAATGATATCGGTTG	0.274													26	23					0	0	0	0	A	32493813	A	A	32493813	2	1	137	1	0	0	0	0	0	0	0	1	4392	1280	45	2		2	DDX58	9	32493813	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	44913	32493813	108719618	99	24654											
GRIN3A	116443	broad.mit.edu	37	chr9	104499666	104499666	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcgccctggctctgggggAaggcgagcagcgccgacacc	6	6	15	14	4	1	0	0	0	1	0	2	3	1	1	3	4	2	2	3	4	1	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:104499666A>G	uc004bbp.1	-	1	1197	c.596T>C	c.(595-597)TTC>TCC	p.F199S	GRIN3A_uc004bbq.1_Missense_Mutation_p.F199S	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	199	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GCTCTGGGGGAAGGCGAGCAG	0.587													3	100					0	0	0	0	G	104499666	G	G	104499666	3	3	137	1	0	0	0	0	1	0	0	0	6822	246	9	5	2787	5	GRIN3A	9	104499666	Missense_Mutation	SNP	A	TCGA-CR-7365-01A-11D-2012-08	72005853	104499666	36713765	100	24655											
RALGDS	5900	broad.mit.edu	37	chr9	136030585	136030585	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccccacggcaaacaccgtGaccccaatggtcaggttcag	10	7	9	15	2	2	1	2	1	0	0	3	1	3	1	5	3	1	2	5	3	2	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:136030585G>A	uc011mcw.1	-	6	657	c.376C>T	c.(376-378)CAC>TAC	p.H126Y	GBGT1_uc004ccx.2_Silent_p.V66V|GBGT1_uc010nab.2_Missense_Mutation_p.H126Y|GBGT1_uc011mcx.1_Silent_p.V96V|GBGT1_uc004ccw.2_Silent_p.V113V|GBGT1_uc010nac.1_5'UTR|GBGT1_uc004ccy.1_Silent_p.V113V	NM_001042368	NP_001035827	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	Error:Variant_position_missing_in_Q12967_after_alignment					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CAAACACCGTGACCCCAATGG	0.587			T	CIITA	PMBL|Hodgkin Lymphona|								35	56					0	0	0	0	A	136030585	A	A	136030585	3	1	137	1	0	0	0	0	1	0	0	0	13081	1277	45	2		2	RALGDS	9	136030585	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	31530919	136030585	5182846	101	24656											
NOTCH1	4851	broad.mit.edu	37	chr9	139400138	139400138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggctctcggatgtgggctCacaggtcccctggttgtagc	4	10	16	11	1	2	0	1	0	1	0	4	1	3	1	2	6	1	4	2	6	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:139400138C>T	uc004chz.2	-	25	4210	c.4210G>A	c.(4210-4212)GAG>AAG	p.E1404K	NOTCH1_uc004cia.1_Missense_Mutation_p.E634K	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1404	Extracellular (Potential).|EGF-like 36.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GATGTGGGCTCACAGGTCCCC	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			35	49					0	0	0	0	T	139400138	T	T	139400138	3	4	137	1	0	0	0	0	1	0	0	0	10601	835	29	2	3497	2	NOTCH1	9	139400138	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	3369553	139400138	1813293	102	24657											
NOTCH1	4851	broad.mit.edu	37	chr9	139410477	139410477	+	Frame_Shift_Del	DEL	T	-	-																															tgttgggtccgtccaggcacTtggcaccattcttgcagggg																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:139410477delT	uc004chz.2	-	10	1625	c.1625delA	c.(1624-1626)AAGfs	p.K542fs	NOTCH1_uc004cia.1_5'Flank	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	542	Extracellular (Potential).|EGF-like 14; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTCCAGGCACTTGGCACCATT	0.667			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								-	139410477	-	-	139410477	7	5	137	1	0	1	0	1	0	0	0	0	10601	1609	56	0	6142	0	NOTCH1	9	139410477	Frame_Shift_Del	DEL	T	TCGA-CR-7365-01A-11D-2012-08	10339	139410477	1802954	103	24658											
ABCA2	20	broad.mit.edu	37	chr9	139910605	139910605	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcggaacccgacgttggaggGaacaggccggtcaggatgga	10	4	18	9	4	1	0	1	0	0	0	1	6	1	5	2	7	2	1	2	7	2	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:139910605G>C	uc011mem.1	-	21	3271	c.3123C>G	c.(3121-3123)TTC>TTG	p.F1041L	ABCA2_uc011mel.1_Missense_Mutation_p.F1042L|ABCA2_uc004ckl.1_Missense_Mutation_p.F972L|ABCA2_uc004ckm.1_Missense_Mutation_p.F1072L|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1041	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		ACGTTGGAGGGAACAGGCCGG	0.652													44	63					0	0	0	0	C	139910605	C	C	139910605	3	2	137	1	0	0	0	0	1	0	0	0	32	1165	41	2	4296	2	ABCA2	9	139910605	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	500128	139910605	1302826	104	24659											
USP6NL	9712	broad.mit.edu	37	chr10	11505446	11505446	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcagttctctctgtagctGagacgtctgacggtttattc	6	15	11	9	2	3	2	0	2	3	1	5	3	3	2	0	2	1	5	0	2	2	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr10:11505446G>A	uc001ikt.3	-	15	1802	c.1481C>T	c.(1480-1482)TCA>TTA	p.S494L	USP6NL_uc001iks.1_Missense_Mutation_p.S511L	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	494						intracellular	Rab GTPase activator activity				0						CTCTGTAGCTGAGACGTCTGA	0.537													46	206					0	0	0	0	A	11505446	A	A	11505446	3	1	137	1	0	0	0	0	1	0	0	0	17155	1294	45	2	1009	2	USP6NL	10	11505446	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08		11505446	124029301	105	24660											
MYO3A	53904	broad.mit.edu	37	chr10	26409613	26409613	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtgtgtttcagcaacttggTagtatatacagcatactcgc	10	13	10	8	1	1	0	1	0	0	0	2	0	1	0	0	2	5	5	0	2	6	7			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr10:26409613T>C	uc001isn.2	+	18	2145	c.1785T>C	c.(1783-1785)GGT>GGC	p.G595G	MYO3A_uc009xko.1_Silent_p.G595G|MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	595	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AGCAACTTGGTAGTATATACA	0.438													12	70					0	0	0	0	C	26409613	C	C	26409613	2	2	137	1	0	0	0	0	0	0	0	1	10129	1625	57	5		5	MYO3A	10	26409613	Silent	SNP	T	TCGA-CR-7365-01A-11D-2012-08	14904167	26409613	109125134	106	24661											
TSPAN14	81619	broad.mit.edu	37	chr10	82269077	82269077	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgtggcaccatcgtgctCatcttcttcctggagctggc	4	14	10	13	1	4	0	1	0	3	0	6	1	5	1	2	3	2	3	2	3	0	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr10:82269077C>T	uc001kcj.3	+	5	407	c.300C>T	c.(298-300)CTC>CTT	p.L100L	TSPAN14_uc009xss.2_Intron|TSPAN14_uc001kci.3_Silent_p.L83L	NM_030927	NP_112189	Q8NG11	TSN14_HUMAN	tetraspanin 14 isoform 1	100	Helical; (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)			CCATCGTGCTCATCTTCTTCC	0.612													23	28					0	0	0	0	T	82269077	T	T	82269077	2	4	137	1	0	0	0	0	0	0	0	1	16705	813	29	2		2	TSPAN14	10	82269077	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	55859464	82269077	53265670	107	24662											
CUEDC2	79004	broad.mit.edu	37	chr10	104184490	104184490	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agttctcctctgatgggcccGaggggcccaggtcctccagg	5	8	14	14	1	2	1	0	1	2	0	5	2	4	1	5	5	0	1	5	5	0	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr10:104184490G>C	uc001kvn.2	-	3	285	c.134C>G	c.(133-135)TCG>TGG	p.S45W	CUEDC2_uc001kvm.2_5'Flank	NM_024040	NP_076945	Q9H467	CUED2_HUMAN	CUE domain containing 2	45						cytoplasm|nucleus	protein binding				0		Colorectal(252;0.122)		Epithelial(162;9.17e-09)|all cancers(201;2.16e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		TGATGGGCCCGAGGGGCCCAG	0.587													30	43					0	0	0	0	C	104184490	C	C	104184490	3	2	137	1	0	0	0	0	1	0	0	0	4070	1059	37	3	757	3	CUEDC2	10	104184490	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	21915413	104184490	31350257	108	24663											
DOCK1	1793	broad.mit.edu	37	chr10	129141970	129141970	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctcaagagtccctgcaactgGagaatttttcaagtgccaag	12	10	9	10	0	2	2	2	0	0	2	3	3	3	2	2	1	3	1	2	1	5	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr10:129141970G>C	uc001ljt.2	+	31	3185	c.3121G>C	c.(3121-3123)GAG>CAG	p.E1041Q	DOCK1_uc010qun.1_Missense_Mutation_p.E1062Q|DOCK1_uc009yaq.2_Missense_Mutation_p.E36Q	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1041					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CCTGCAACTGGAGAATTTTTC	0.433													2	7					0	0	0	0	C	129141970	C	C	129141970	3	2	137	1	0	0	0	0	1	0	0	0	4706	1175	41	2	3243	2	DOCK1	10	129141970	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	24957480	129141970	6392777	109	24664											
HBD	3045	broad.mit.edu	37	chr11	5255269	5255269	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtcacagtgcagctcactCagctgagaaaaagtgccctt	11	10	9	11	0	3	1	3	1	0	1	3	2	3	1	1	0	4	3	1	0	2	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:5255269C>G	uc001maf.1	-	2	462	c.267G>C	c.(265-267)CTG>CTC	p.L89L		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	89					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAGCTCACTCAGCTGAGAAA	0.493													30	60					0	0	0	0	G	5255269	G	G	5255269	2	3	137	1	0	0	0	0	0	0	0	1	7018	813	29	2		2	HBD	11	5255269	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08		5255269	129751247	110	24665											
ABCC8	6833	broad.mit.edu	37	chr11	17427072	17427072	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttacagtcagatgaaaatCtgttcaggatgctcccaagg	12	11	10	8	0	3	2	2	1	1	1	4	3	4	3	1	2	2	3	1	2	4	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:17427072C>G	uc001mnc.2	-	27	3494	c.3368G>C	c.(3367-3369)AGA>ACA	p.R1123T		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1123	Cytoplasmic (By similarity).|ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGATGAAAATCTGTTCAGGAT	0.512													46	101					0	0	0	0	G	17427072	G	G	17427072	3	3	137	1	0	0	0	0	1	0	0	0	58	913	32	2	1429	2	ABCC8	11	17427072	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	12171803	17427072	117579444	111	24666											
SLC6A5	9152	broad.mit.edu	37	chr11	20622705	20622705	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcccaaggaaatgaataaaCtgccagccaacagcccggag	15	4	9	13	1	0	1	0	1	0	0	1	3	1	3	4	2	5	0	4	2	6	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:20622705C>G	uc001mqd.2	+	2	307	c.34C>G	c.(34-36)CTG>GTG	p.L12V	SLC6A5_uc009yic.2_5'UTR	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	12	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	AATGAATAAACTGCCAGCCAA	0.572													6	17					0	0	0	0	G	20622705	G	G	20622705	3	3	137	1	0	0	0	0	1	0	0	0	14751	564	20	4	40	4	SLC6A5	11	20622705	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	3195633	20622705	114383811	112	24667											
CATSPER1	117144	broad.mit.edu	37	chr11	65793518	65793518	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcatcatggtagtcctcaccGtaggaacggtgggaggggac	9	8	15	9	2	3	0	3	0	0	0	4	3	4	3	2	6	1	2	2	6	3	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:65793518G>A	uc001ogt.2	-	1	471	c.333C>T	c.(331-333)TAC>TAT	p.Y111Y		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	111	His-rich.|Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						AGTCCTCACCGTAGGAACGGT	0.597													22	125					0	0	0	0	A	65793518	A	A	65793518	2	1	137	1	0	0	0	0	0	0	0	1	2699	1140	40	1		1	CATSPER1	11	65793518	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	45170813	65793518	69212998	113	24668											
ARAP1	116985	broad.mit.edu	37	chr11	72406446	72406446	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctaccttgatatgctgctCagtctctgccttcttctctt	5	17	5	14	0	4	1	1	1	3	0	6	1	4	1	3	0	4	2	3	0	2	6			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:72406446C>G	uc001osu.2	-	26	3751	c.3562G>C	c.(3562-3564)GAG>CAG	p.E1188Q	ARAP1_uc001osv.2_Missense_Mutation_p.E1188Q|ARAP1_uc001osr.2_Missense_Mutation_p.E948Q|ARAP1_uc001oss.2_Missense_Mutation_p.E943Q|ARAP1_uc009yth.2_Missense_Mutation_p.E882Q|ARAP1_uc010rre.1_Missense_Mutation_p.E943Q	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1188	Ras-associating.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						ATATGCTGCTCAGTCTCTGCC	0.577													14	52					0	0	0	0	G	72406446	G	G	72406446	3	3	137	1	0	0	0	0	1	0	0	0	838	835	29	2	830	2	ARAP1	11	72406446	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	6612928	72406446	62600070	114	24669											
ARAP1	116985	broad.mit.edu	37	chr11	72406880	72406880	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgccaggttgtgcacgttCatctggttcgtgtctgagaa	7	14	12	8	2	3	1	1	1	2	1	4	2	3	1	1	2	2	4	1	2	1	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:72406880C>T	uc001osu.2	-	24	3492	c.3303G>A	c.(3301-3303)ATG>ATA	p.M1101I	ARAP1_uc001osv.2_Missense_Mutation_p.M1101I|ARAP1_uc001osr.2_Missense_Mutation_p.M861I|ARAP1_uc001oss.2_Missense_Mutation_p.M856I|ARAP1_uc009yth.2_Missense_Mutation_p.M795I|ARAP1_uc010rre.1_Missense_Mutation_p.M856I	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1101	Rho-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						TGTGCACGTTCATCTGGTTCG	0.537													14	23					0	0	0	0	T	72406880	T	T	72406880	3	4	137	1	0	0	0	0	1	0	0	0	838	826	29	2	1097	2	ARAP1	11	72406880	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	434	72406880	62599636	115	24670											
C2CD3	26005	broad.mit.edu	37	chr11	73789689	73789689	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctccagaccacccacgatCttctgcatgagctccaggcc	9	7	8	17	1	2	2	0	1	2	1	4	3	4	2	5	1	3	3	5	1	0	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:73789689C>G	uc001ouu.2	-	23	4301	c.4074G>C	c.(4072-4074)AAG>AAC	p.K1358N	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1358						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					CACCCACGATCTTCTGCATGA	0.498													41	71					0	0	0	0	G	73789689	G	G	73789689	3	3	137	1	0	0	0	0	1	0	0	0	2164	912	32	2	1853	2	C2CD3	11	73789689	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	1382809	73789689	61216827	116	24671											
ODZ4	26011	broad.mit.edu	37	chr11	78381038	78381038	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaaacttcccaaactgctCtgtcttgcctgacacatcat	11	11	4	15	0	3	1	1	1	2	0	4	1	4	1	3	0	4	1	3	0	2	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:78381038C>T	uc001ozl.3	-	32	6815	c.6352G>A	c.(6352-6354)GAG>AAG	p.E2118K	ODZ4_uc001ozk.3_Missense_Mutation_p.E343K|ODZ4_uc009yvb.1_Missense_Mutation_p.E702K	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2118	YD 14.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CCAAACTGCTCTGTCTTGCCT	0.478													19	26					0	0	0	0	T	78381038	T	T	78381038	3	4	137	1	0	0	0	0	1	0	0	0	10891	922	32	2	1969	2	ODZ4	11	78381038	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	4591349	78381038	56625478	117	24672											
CASP1	834	broad.mit.edu	37	chr11	104901918	104901918	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgacttttgtttccatatccTttgagcttcttctagggagc	6	17	8	10	1	2	1	0	1	2	0	4	3	4	2	2	1	2	2	2	1	2	8			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:104901918T>C	uc010rve.1	-	4	444	c.427A>G	c.(427-429)AGG>GGG	p.R143G	CASP1_uc001pig.2_Missense_Mutation_p.R50G|CASP1_uc001pik.2_Missense_Mutation_p.R106G|CASP1_uc010rvf.1_Missense_Mutation_p.R50G|CASP1_uc010rvg.1_Missense_Mutation_p.R122G|CASP1_uc010rvh.1_Missense_Mutation_p.R50G|CASP1_uc010rvi.1_Intron|CASP1_uc001pim.3_Missense_Mutation_p.R143G|CASP1_uc009yxi.2_Missense_Mutation_p.R122G|CASP1_uc010rvj.1_Missense_Mutation_p.R143G|CASP1_uc009yxj.2_Intron|CASP1_uc010rvk.1_Missense_Mutation_p.R104G|CASP1_uc010rvl.1_Missense_Mutation_p.R143G	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	143					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TTCCATATCCTTTGAGCTTCT	0.507													16	24					0	0	0	0	C	104901918	C	C	104901918	3	2	137	1	0	0	0	0	1	0	0	0	2680	1608	56	5	811	5	CASP1	11	104901918	Missense_Mutation	SNP	T	TCGA-CR-7365-01A-11D-2012-08	26520880	104901918	30104598	118	24673											
MLL	4297	broad.mit.edu	37	chr11	118339526	118339526	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttggctcagatgaagaaGtcagagtgcgaagtcccaca	12	9	12	8	1	2	4	2	1	0	3	3	5	3	4	1	1	1	2	1	1	3	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:118339526G>A	uc001pta.2	+	2	492	c.469G>A	c.(469-471)GTC>ATC	p.V157I	MLL_uc001ptb.2_Missense_Mutation_p.V157I|MLL_uc001psz.1_Missense_Mutation_p.V190I|MLL_uc001ptd.1_5'UTR	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	157					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AGATGAAGAAGTCAGAGTGCG	0.408			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								19	28					0	0	0	0	A	118339526	A	A	118339526	3	1	137	1	0	0	0	0	1	0	0	0	9673	1029	36	4	475	4	MLL	11	118339526	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	13437608	118339526	16666990	119	24674											
SLC37A4	2542	broad.mit.edu	37	chr11	118895769	118895769	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggtgctgaagggcagccCagccagaaagccgcccactg	11	4	13	13	1	0	2	0	1	0	1	0	2	0	2	4	2	4	2	4	2	3	0			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:118895769C>T	uc010rys.1	-	11	1898	c.1141G>A	c.(1141-1143)GGG>AGG	p.G381R	SLC37A4_uc009zam.2_RNA|SLC37A4_uc009zan.2_RNA|SLC37A4_uc010ryr.1_Missense_Mutation_p.G403R|SLC37A4_uc010ryt.1_Missense_Mutation_p.G308R|SLC37A4_uc001pus.2_Missense_Mutation_p.G381R	NM_001164277	NP_001157749	O43826	G6PT1_HUMAN	solute carrier family 37 (glucose-6-phosphate	381	Helical; (Potential).				glucose homeostasis|glucose metabolic process	endoplasmic reticulum membrane|integral to endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphate transmembrane transporter activity|glucose-6-phosphate transmembrane transporter activity			large_intestine(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		AAGGGCAGCCCAGCCAGAAAG	0.582									Glycogen_Storage_Disease_type_Ib				30	53					0	0	0	0	T	118895769	T	T	118895769	3	4	137	1	0	0	0	0	1	0	0	0	14664	594	21	4	152	4	SLC37A4	11	118895769	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	556243	118895769	16110747	120	24675											
MFRP	83552	broad.mit.edu	37	chr11	119214569	119214569	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgagctgctggtctcatacaCctccacgtagtcaaacttgc	9	11	8	13	1	2	1	2	1	1	0	4	1	3	1	2	1	5	3	2	1	3	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:119214569C>A	uc001pwj.2	-	9	1241	c.1081G>T	c.(1081-1083)GTG>TTG	p.V361L	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Intron	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		GTCTCATACACCTCCACGTAG	0.582													38	83					4.32679e-17	4.91589e-17	1	0	A	119214569	A	A	119214569	3	1	137	1	0	0	0	0	1	0	0	0	9579	507	18	4	678	4	MFRP	11	119214569	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	318800	119214569	15791947	121	24676											
EI24	9538	broad.mit.edu	37	chr11	125453532	125453532	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgcagagaagttcccttCaccgcatccgtcgcctgcca	7	10	8	16	3	2	1	1	0	1	1	5	2	4	1	5	0	2	3	5	0	1	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:125453532C>A	uc001qca.2	+	12	1219	c.977C>A	c.(976-978)TCA>TAA	p.S326*	EI24_uc001qcb.2_3'UTR|EI24_uc010sbd.1_RNA|EI24_uc009zbl.2_Nonsense_Mutation_p.S327*|EI24_uc001qcc.2_RNA|EI24_uc010sbe.1_Nonsense_Mutation_p.S313*|EI24_uc010sbf.1_RNA	NM_004879	NP_004870	O14681	EI24_HUMAN	etoposide induced 2.4 isoform 1	326					apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		AAGTTCCCTTCACCGCATCCG	0.552													15	22					1.3612e-06	1.44479e-06	1	0	A	125453532	A	A	125453532	4	1	137	1	0	0	0	0	0	1	0	0	5007	838	29	2	1014	2	EI24	11	125453532	Nonsense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	6238963	125453532	9552984	122	24677											
SLCO1A2	6579	broad.mit.edu	37	chr12	21471722	21471722	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaataattcattaccaatctCaaagcttccattaatgaatc	17	13	2	9	0	2	1	2	1	1	0	5	1	3	1	2	0	2	1	2	0	7	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:21471722C>G	uc001rer.2	-	2	447	c.196G>C	c.(196-198)GAG>CAG	p.E66Q	SLCO1A2_uc001res.2_Missense_Mutation_p.E66Q|SLCO1A2_uc010siq.1_5'UTR|SLCO1A2_uc010sio.1_5'UTR|SLCO1A2_uc010sip.1_Intron|SLCO1A2_uc001ret.2_Missense_Mutation_p.E64Q|SLCO1A2_uc001reu.2_Missense_Mutation_p.E46Q	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	66	Helical; Name=2; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TTACCAATCTCAAAGCTTCCA	0.328													23	61					0	0	0	0	G	21471722	G	G	21471722	3	3	137	1	0	0	0	0	1	0	0	0	14786	835	29	2	1868	2	SLCO1A2	12	21471722	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08		21471722	112380173	123	24678											
IFLTD1	160492	broad.mit.edu	37	chr12	25672833	25672833	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttccacctgataatttgaGatatctttcttaggttgatc	9	18	7	7	0	2	3	0	3	2	1	4	4	3	3	2	1	0	2	2	1	3	7			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:25672833G>C	uc001rgs.2	-	6	1062	c.912C>G	c.(910-912)ATC>ATG	p.I304M	IFLTD1_uc001rgt.1_Missense_Mutation_p.I207M|IFLTD1_uc010sji.1_Missense_Mutation_p.I325M|IFLTD1_uc010sjj.1_Missense_Mutation_p.I241M|IFLTD1_uc009zjc.2_Missense_Mutation_p.I285M	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	304						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					GATAATTTGAGATATCTTTCT	0.373													18	40					0	0	0	0	C	25672833	C	C	25672833	3	2	137	1	0	0	0	0	1	0	0	0	7569	932	33	2	266	2	IFLTD1	12	25672833	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	4201111	25672833	108179062	124	24679											
C12orf41	54934	broad.mit.edu	37	chr12	49073534	49073534	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggcacaggagtgtttcacCcacaggccctgggttggtct	6	10	13	12	0	2	0	1	0	1	0	2	1	2	1	2	5	0	3	2	5	0	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:49073534C>T	uc001rrx.2	-	3	409	c.334G>A	c.(334-336)GGT>AGT	p.G112S	C12orf41_uc001rrw.2_5'UTR|C12orf41_uc001rrz.2_Missense_Mutation_p.G295S|C12orf41_uc001rry.2_RNA	NM_017822	NP_060292	Q9H9L4	CL041_HUMAN	hypothetical protein LOC54934	112										ovary(2)	2						AGTGTTTCACCCACAGGCCCT	0.507													6	17					0	0	0	0	T	49073534	T	T	49073534	3	4	137	1	0	0	0	0	1	0	0	0	1693	623	22	4	1176	4	C12orf41	12	49073534	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	23400701	49073534	84778361	125	24680											
EIF4B	1975	broad.mit.edu	37	chr12	53410267	53410267	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaaaacagcaaaaaagaaGaataagaaggggaagactat	23	6	9	3	0	0	4	0	0	0	4	0	5	0	5	0	2	2	1	0	2	11	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:53410267G>C	uc001sbh.3	+	2	230	c.24G>C	c.(22-24)AAG>AAC	p.K8N	EIF4B_uc009zmp.1_RNA|EIF4B_uc010snu.1_Missense_Mutation_p.K8N|EIF4B_uc010snv.1_Missense_Mutation_p.K8N|EIF4B_uc001sbi.2_5'UTR	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	8					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						CAAAAAAGAAGAATAAGAAGG	0.393													10	29					0	0	0	0	C	53410267	C	C	53410267	3	2	137	1	0	0	0	0	1	0	0	0	5051	933	33	2	30	2	EIF4B	12	53410267	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	4336733	53410267	80441628	126	24681											
TIMELESS	8914	broad.mit.edu	37	chr12	56816656	56816656	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccagggagccatagccctCagtcatctctcgaaccacag	11	7	8	15	1	3	0	2	0	1	0	6	2	4	1	4	1	3	0	4	1	2	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:56816656C>T	uc001slf.2	-	19	2581	c.2413G>A	c.(2413-2415)GAG>AAG	p.E805K		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	805					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CCATAGCCCTCAGTCATCTCT	0.448													38	59					0	0	0	0	T	56816656	T	T	56816656	3	4	137	1	0	0	0	0	1	0	0	0	15970	835	29	2	1257	2	TIMELESS	12	56816656	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	3406389	56816656	77035239	127	24682											
LGR5	8549	broad.mit.edu	37	chr12	71965319	71965319	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcttacaacctattagaaGatttacccagtttttcagtc	11	16	5	9	0	2	2	1	0	1	2	3	2	2	2	2	0	3	1	2	0	6	7			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:71965319G>C	uc001swl.2	+	12	1144	c.1096G>C	c.(1096-1098)GAT>CAT	p.D366H	LGR5_uc001swm.2_Missense_Mutation_p.D342H|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	366	LRR 13.|Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						CCTATTAGAAGATTTACCCAG	0.338													7	28					0	0	0	0	C	71965319	C	C	71965319	3	2	137	1	0	0	0	0	1	0	0	0	8798	942	33	2	1142	2	LGR5	12	71965319	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	15148663	71965319	61886576	128	24683											
KSR2	283455	broad.mit.edu	37	chr12	118105354	118105354	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcccacaaagaaggagcGgagggagcgctcggacagca	12	3	16	10	3	0	1	0	0	0	1	2	5	1	5	1	4	3	2	1	4	2	0			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:118105354G>A	uc001two.2	-	5	1064	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	366					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAGAAGGAGCGGAGGGAGCGC	0.602													11	19					0	0	0	0	A	118105354	A	A	118105354	3	1	137	1	0	0	0	0	1	0	0	0	8622	1116	39	1	1820	1	KSR2	12	118105354	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	46140035	118105354	15746541	129	24684											
GCN1L1	10985	broad.mit.edu	37	chr12	120600729	120600729	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataaaggcttcaggatcgatCttcatcctggcaagaagtgc	12	10	10	9	1	3	1	2	0	1	1	5	3	4	2	1	3	1	2	1	3	4	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:120600729C>T	uc001txo.2	-	20	2098	c.2085G>A	c.(2083-2085)AAG>AAA	p.K695K		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	695					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGGATCGATCTTCATCCTGG	0.557													38	74					0	0	0	0	T	120600729	T	T	120600729	2	4	137	1	0	0	0	0	0	0	0	1	6334	912	32	2		2	GCN1L1	12	120600729	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	2495375	120600729	13251166	130	24685											
KNTC1	9735	broad.mit.edu	37	chr12	123061462	123061462	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagtggttagatacattctCaaacaagatgtcccatcttc	13	12	7	9	0	2	3	1	0	2	3	5	3	3	3	1	1	2	1	1	1	4	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:123061462C>G	uc001ucv.2	+	30	2770	c.2607C>G	c.(2605-2607)CTC>CTG	p.L869L	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	869					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GATACATTCTCAAACAAGATG	0.348													14	21					0	0	0	0	G	123061462	G	G	123061462	2	3	137	1	0	0	0	0	0	0	0	1	8467	813	29	2		2	KNTC1	12	123061462	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	2460733	123061462	10790433	131	24686											
LMO7	4008	broad.mit.edu	37	chr13	76381901	76381901	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgagcaagatgattctgtAgagcgagatataattttaca	14	13	9	5	1	2	5	0	2	2	3	2	6	2	5	0	0	3	2	0	0	5	6			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr13:76381901A>G	uc001vjv.2	+	7	1543	c.783A>G	c.(781-783)GTA>GTG	p.V261V	LMO7_uc010thv.1_Intron|LMO7_uc001vjt.1_Intron|LMO7_uc010thw.1_Intron|LMO7_uc001vjw.1_Silent_p.V167V	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	546						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		ATGATTCTGTAGAGCGAGATA	0.388													30	59					0	0	0	0	G	76381901	G	G	76381901	2	3	137	1	0	0	0	0	0	0	0	1	8897	407	15	5		5	LMO7	13	76381901	Silent	SNP	A	TCGA-CR-7365-01A-11D-2012-08		76381901	38787977	132	24687											
DOCK9	23348	broad.mit.edu	37	chr13	99498246	99498246	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcatgcatcattcctgttCtgttacgggaaacaggcaat	10	12	10	9	1	2	0	1	0	1	0	3	1	3	1	1	3	3	5	1	3	3	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr13:99498246C>G	uc001vnt.2	-	38	4120	c.4065_splice	c.e38-1	p.R1355_splice	DOCK9_uc001vnw.2_Splice_Site_p.R1354_splice|DOCK9_uc001vnv.1_Splice_Site|DOCK9_uc010tir.1_Splice_Site_p.R1355_splice|DOCK9_uc001vnq.2_5'UTR|DOCK9_uc001vnr.2_5'UTR|DOCK9_uc010tin.1_5'UTR|DOCK9_uc001vns.2_Intron|DOCK9_uc010tio.1_Missense_Mutation_p.R47T|DOCK9_uc010tip.1_Missense_Mutation_p.R65T|DOCK9_uc001vnu.1_5'UTR|DOCK9_uc010tiq.1_Splice_Site_p.R333_splice	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a						blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CATTCCTGTTCTGTTACGGGA	0.483													7	16					0	0	0	0	G	99498246	G	G	99498246	5	3	137	1	0	0	0	0	0	0	1	0	4716	927	32	2	2217	2	DOCK9	13	99498246	Splice_Site	SNP	C	TCGA-CR-7365-01A-11D-2012-08	23116345	99498246	15671632	133	24688											
MYH7	4625	broad.mit.edu	37	chr14	23893298	23893298	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcaccttggcctccagctGaatcttgtttttgatcagct	6	16	7	12	0	3	2	2	2	1	0	4	2	4	2	3	1	2	3	3	1	1	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr14:23893298G>T	uc001wjx.2	-	23	2846	c.2740C>A	c.(2740-2742)CAG>AAG	p.Q914K		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	914	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCCTCCAGCTGAATCTTGTTT	0.532													28	66					2.44723e-14	2.72917e-14	1	0	T	23893298	T	T	23893298	3	4	137	1	0	0	0	0	1	0	0	0	10092	1299	45	2	3139	2	MYH7	14	23893298	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08		23893298	83456242	134	24689											
FSCB	84075	broad.mit.edu	37	chr14	44975541	44975541	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttagtctcctgagtaaatGaagttctgctgatatttttc	9	19	7	6	0	2	3	0	3	2	0	4	3	2	3	1	0	1	3	1	0	5	7			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr14:44975541G>A	uc001wvn.2	-	1	959	c.650C>T	c.(649-651)TCA>TTA	p.S217L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	217						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CTGAGTAAATGAAGTTCTGCT	0.393													26	64					0	0	0	0	A	44975541	A	A	44975541	3	1	137	1	0	0	0	0	1	0	0	0	6100	1294	45	2	1831	2	FSCB	14	44975541	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	21082243	44975541	62373999	135	24690											
MTHFD1	4522	broad.mit.edu	37	chr14	64906869	64906879	+	Frame_Shift_Del	DEL	GTGAAATTATG	-	-																															gtttgatatctctgtggccaGtgaaattatggctgtcctgg																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr14:64906869_64906879delGTGAAATTATG	uc001xhb.2	+	18	2087_2097	c.1700_1710delGTGAAATTATG	c.(1699-1710)AGTGAAATTATGfs	p.S567fs	MTHFD1_uc010aqe.2_Frame_Shift_Del_p.S603fs|MTHFD1_uc010aqf.2_Frame_Shift_Del_p.S623fs	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	567_570	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TCTGTGGCCAGTGAAATTATGGCTGTCCTGG	0.479													---	---	---								-	64906879	-	-	64906869	7	5	137	1	0	1	0	1	0	0	0	0	9980	1029	36	0	1770	0	MTHFD1	14	64906869	Frame_Shift_Del	DEL	GTGAAATTATG	TCGA-CR-7365-01A-11D-2012-08	19931328	64906869	42442671	136	24691											
C14orf49	161176	broad.mit.edu	37	chr14	95906295	95906295	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcatcccccgggcccgcctCtccccggtgtgcctccagct	2	7	11	21	3	1	0	0	0	1	0	4	0	3	0	8	3	2	2	8	3	0	0			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr14:95906295C>G	uc001yei.3	-	11	2044	c.2029G>C	c.(2029-2031)GAG>CAG	p.E677Q	C14orf49_uc010avi.2_Missense_Mutation_p.E677Q	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	677	Spectrin 2.|Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		GGGCCCGCCTCTCCCCGGTGT	0.637													75	66					0	0	0	0	G	95906295	G	G	95906295	3	3	137	1	0	0	0	0	1	0	0	0	1782	922	32	2	926	2	C14orf49	14	95906295	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	30999426	95906295	11443245	137	24692											
DYNC1H1	1778	broad.mit.edu	37	chr14	102504835	102504835	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagttttgaacccggtgctGaaccgtgaagtgcggcgaac	9	8	13	11	4	0	3	0	3	0	0	0	4	0	3	3	2	5	2	3	2	4	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr14:102504835G>C	uc001yks.2	+	58	11111	c.10947G>C	c.(10945-10947)CTG>CTC	p.L3649L		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3649	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding	p.L3649V(1)		ovary(7)|central_nervous_system(2)|pancreas(1)	10						ACCCGGTGCTGAACCGTGAAG	0.542													7	34					0	0	0	0	C	102504835	C	C	102504835	2	2	137	1	0	0	0	0	0	0	0	1	4863	1277	45	2		2	DYNC1H1	14	102504835	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	6598540	102504835	4844705	138	24693											
EPB42	2038	broad.mit.edu	37	chr15	43508574	43508574	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccctcctcacaaagaggcGccgggagctgagggccttgg	7	5	14	15	2	1	2	1	1	0	1	2	3	2	3	5	4	1	1	5	4	1	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:43508574G>A	uc001zra.3	-	2	388	c.88C>T	c.(88-90)CGC>TGC	p.R30C	EPB42_uc010bde.2_5'UTR|EPB42_uc001zrb.3_Missense_Mutation_p.R60C|EPB42_uc010udm.1_Missense_Mutation_p.R30C	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	30					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		ACAAAGAGGCGCCGGGAGCTG	0.582													27	50					0	0	0	0	A	43508574	A	A	43508574	3	1	137	1	0	0	0	0	1	0	0	0	5182	1087	38	1	2035	1	EPB42	15	43508574	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08		43508574	59022818	139	24694											
CATSPER2	117155	broad.mit.edu	37	chr15	43924464	43924464	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttctagcaactcaaaataTcggaagagtgagtctctggg	12	12	10	7	1	3	2	1	1	2	1	5	3	3	3	0	2	2	1	0	2	6	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:43924464T>C	uc001zsh.2	-	12	1709	c.1494A>G	c.(1492-1494)CGA>CGG	p.R498R	STRC_uc010udz.1_RNA|CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Silent_p.R496R|CATSPER2_uc001zsj.2_Silent_p.R496R	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	498	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		ACTCAAAATATCGGAAGAGTG	0.483													21	53					0	0	0	0	C	43924464	C	C	43924464	2	2	137	1	0	0	0	0	0	0	0	1	2700	1422	50	5		5	CATSPER2	15	43924464	Silent	SNP	T	TCGA-CR-7365-01A-11D-2012-08	415890	43924464	58606928	140	24695											
SHC4	399694	broad.mit.edu	37	chr15	49126974	49126974	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtcaatgataccttgccttCaggatccaccaggagaagat	13	9	9	10	0	2	3	2	1	0	2	3	5	3	4	4	2	2	0	4	2	3	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:49126974C>T	uc001zxb.1	-	11	2158	c.1729G>A	c.(1729-1731)GAA>AAA	p.E577K	SHC4_uc010uey.1_Missense_Mutation_p.E334K|SHC4_uc010uez.1_Missense_Mutation_p.E291K	NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	577	SH2.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		ACCTTGCCTTCAGGATCCACC	0.453													33	85					0	0	0	0	T	49126974	T	T	49126974	3	4	137	1	0	0	0	0	1	0	0	0	14338	835	29	2	171	2	SHC4	15	49126974	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	5202510	49126974	53404418	141	24696											
LACTB	114294	broad.mit.edu	37	chr15	63419597	63419597	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttcccatttaagtggaattCgtcattatgaaaaggacata	14	14	7	6	1	1	1	1	1	0	0	3	3	2	3	1	2	0	0	1	2	6	6			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:63419597C>T	uc002alw.2	+	4	700	c.661C>T	c.(661-663)CGT>TGT	p.R221C	LACTB_uc002alv.2_Missense_Mutation_p.R221C	NM_032857	NP_116246	P83111	LACTB_HUMAN	lactamase, beta isoform a	221						mitochondrion	hydrolase activity				0						AAGTGGAATTCGTCATTATGA	0.299													34	85					0	0	0	0	T	63419597	T	T	63419597	3	4	137	1	0	0	0	0	1	0	0	0	8637	884	31	1	675	1	LACTB	15	63419597	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	14292623	63419597	39111795	142	24697											
CSPG4	1464	broad.mit.edu	37	chr15	75982391	75982391	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctggtgtcaggcccaggcGgtgttcctggaggtgacgag	5	9	17	10	2	2	1	1	1	1	0	3	3	3	2	2	6	0	1	2	6	0	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:75982391G>A	uc002baw.2	-	3	1108	c.1015C>T	c.(1015-1017)CGC>TGC	p.R339C		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	339	Extracellular (Potential).|Neurite growth inhibition (By similarity).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						AGGCCCAGGCGGTGTTCCTGG	0.642													5	37					0	0	0	0	A	75982391	A	A	75982391	3	1	137	1	0	0	0	0	1	0	0	0	3977	1116	39	1	5985	1	CSPG4	15	75982391	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	12562794	75982391	26549001	143	24698											
C15orf27	123591	broad.mit.edu	37	chr15	76426621	76426621	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acccatggctgtggctccatCtttcaacatgaccaatccac	10	10	6	15	0	2	1	1	1	1	0	4	1	4	1	4	2	1	2	4	2	2	1	rs114291110	by1000genomes	TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:76426621C>G	uc002bbq.2	+	2	172	c.17C>G	c.(16-18)TCT>TGT	p.S6C	C15orf27_uc010bkp.2_Translation_Start_Site	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	6						integral to membrane					0						GTGGCTCCATCTTTCAACATG	0.463													26	38					0	0	0	0	G	76426621	G	G	76426621	3	3	137	1	0	0	0	0	1	0	0	0	1794	913	32	2	19	2	C15orf27	15	76426621	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	444230	76426621	26104771	144	24699											
IL16	3603	broad.mit.edu	37	chr15	81565513	81565513	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caaaaccatttttgcaggggGagcagcagcagccgatggaa	13	6	13	9	1	0	0	0	0	0	0	0	3	0	2	2	3	6	4	2	3	3	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:81565513G>T	uc002bgh.3	+	6	1134	c.758G>T	c.(757-759)GGA>GTA	p.G253V	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.G253V|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.G295V|IL16_uc002bgg.2_Missense_Mutation_p.G253V	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	253	Interaction with GRIN2A.|PDZ 1.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						TTTGCAGGGGGAGCAGCAGCA	0.522													18	42					6.49762e-13	7.14738e-13	1	0	T	81565513	T	T	81565513	3	4	137	1	0	0	0	0	1	0	0	0	7672	1174	41	2	776	2	IL16	15	81565513	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	5138892	81565513	20965879	145	24700											
IFT140	9742	broad.mit.edu	37	chr16	1573848	1573848	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtggtacagcatgaccGccctgtccatctgcacgccc	6	9	9	17	2	1	1	0	1	1	0	2	1	2	1	5	1	3	3	5	1	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:1573848G>A	uc002cmb.2	-	25	3613	c.3251C>T	c.(3250-3252)GCG>GTG	p.A1084V	IFT140_uc002clz.2_Missense_Mutation_p.A697V	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	1084	TPR 6.									ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				CAGCATGACCGCCCTGTCCAT	0.672													13	38					0	0	0	0	A	1573848	A	A	1573848	3	1	137	1	0	0	0	0	1	0	0	0	7595	1087	38	1	1165	1	IFT140	16	1573848	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08		1573848	88780905	146	24701											
FAM100A	124402	broad.mit.edu	37	chr16	4664715	4664715	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gccgcctgcagcagttgcttCgcctggtcggccgcgcagcc	3	7	14	17	5	0	0	0	0	0	0	2	0	0	0	5	2	4	5	5	2	0	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:4664715C>G	uc002cwx.2	-	1	213	c.84G>C	c.(82-84)GCG>GCC	p.A28A	FAM100A_uc010btv.1_Silent_p.A28A|FAM100A_uc002cwy.2_Silent_p.A28A	NM_145253	NP_660296	Q8TB05	F100A_HUMAN	hypothetical protein LOC124402	28											0						GCAGTTGCTTCGCCTGGTCGG	0.731													4	23					0	0	0	0	G	4664715	G	G	4664715	2	3	137	1	0	0	0	0	0	0	0	1	5406	871	31	3		3	FAM100A	16	4664715	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	3090867	4664715	85690038	147	24702											
TNRC6A	27327	broad.mit.edu	37	chr16	24802886	24802887	+	Frame_Shift_Ins	INS	-	T	T																															aggctggctggggggacctaINStaccagccccagcaaaagaa																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:24802886_24802887insT	uc002dmm.2	+	6	3037_3038	c.2923_2924insT	c.(2923-2925)ATAfs	p.I975fs	TNRC6A_uc010bxs.2_Frame_Shift_Ins_p.I722fs|TNRC6A_uc010vcc.1_Frame_Shift_Ins_p.I722fs|TNRC6A_uc002dmn.2_Frame_Shift_Ins_p.I722fs|TNRC6A_uc002dmo.2_Frame_Shift_Ins_p.I722fs	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	975	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GGGGGGACCTATACCAGCCCCA	0.525													---	---	---								T	24802887	T	T	24802886	7	5	137	1	0	1	1	0	0	0	0	0	16406	449	16	0	2945	0	TNRC6A	16	24802886	Frame_Shift_Ins	INS	-	TCGA-CR-7365-01A-11D-2012-08	20138171	24802886	65551867	148	24703											
CORO1A	11151	broad.mit.edu	37	chr16	30199820	30199820	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctacgtacccccaaagagcCgggagctgagggtcaaccgg	10	4	14	13	3	1	2	1	1	0	1	1	3	1	3	4	3	5	3	4	3	4	2	rs150186033	byFrequency	TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:30199820C>T	uc002dww.2	+	10	1326	c.1204C>T	c.(1204-1206)CGG>TGG	p.R402W	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Missense_Mutation_p.R402W|CORO1A_uc010bzr.2_Intron|CORO1A_uc002dwx.2_Missense_Mutation_p.R296W|CORO1A_uc002dwy.1_3'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	402					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						CCCAAAGAGCCGGGAGCTGAG	0.701													20	29					0	0	0	0	T	30199820	T	T	30199820	3	4	137	1	0	0	0	0	1	0	0	0	3768	643	23	1	1238	1	CORO1A	16	30199820	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	5396934	30199820	60154933	149	24704											
BBS2	583	broad.mit.edu	37	chr16	56539947	56539947	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctcatggcatgatttttcGactgaaaaagaattttaata	14	15	7	5	1	1	3	1	2	0	1	2	4	1	3	0	1	1	2	0	1	5	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:56539947G>A	uc002ejd.2	-	7	953	c.719C>T	c.(718-720)TCG>TTG	p.S240L	BBS2_uc010ccg.2_Missense_Mutation_p.S240L	NM_031885	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein	240					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1						ATGATTTTTCGACTGAAAAAG	0.343									Bardet-Biedl_syndrome				10	24					0	0	0	0	A	56539947	A	A	56539947	3	1	137	1	0	0	0	0	1	0	0	0	1340	1072	37	1	1490	1	BBS2	16	56539947	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	26340127	56539947	33814806	150	24705											
PKD1L2	114780	broad.mit.edu	37	chr16	81219116	81219116	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgactcgaggcctgagttCccagggcgcagacacgtaga	9	6	13	13	3	0	4	0	2	0	2	2	5	1	4	3	2	0	3	3	2	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:81219116C>A	uc002fgh.1	-	11	1978	c.1978G>T	c.(1978-1980)GAA>TAA	p.E660*	PKD1L2_uc002fgj.2_Nonsense_Mutation_p.E660*	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	660	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCCTGAGTTCCCAGGGCGCA	0.542													9	23					0.000274275	0.000283652	1	0	A	81219116	A	A	81219116	4	1	137	1	0	0	0	0	0	1	0	0	12020	864	30	2	5602	2	PKD1L2	16	81219116	Nonsense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	24679169	81219116	9135637	151	24706											
ZZEF1	23140	broad.mit.edu	37	chr17	3981229	3981229	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctccagagtccgtgctcttCagctgcaggtagcaccagga	8	8	12	13	1	2	1	1	0	1	1	4	2	4	2	3	2	4	6	3	2	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:3981229C>T	uc002fxe.2	-	19	3001	c.2937G>A	c.(2935-2937)CTG>CTA	p.L979L	ZZEF1_uc002fxk.1_Silent_p.L980L	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	979							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCGTGCTCTTCAGCTGCAGGT	0.512													24	46					0	0	0	0	T	3981229	T	T	3981229	2	4	137	1	0	0	0	0	0	0	0	1	18322	813	29	2		2	ZZEF1	17	3981229	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08		3981229	77213981	152	24707											
TP53	7157	broad.mit.edu	37	chr17	7578203	7578203	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggctcatagggcaccaccaCactatgtcgaaaagtgtttc	11	9	9	12	2	1	0	1	0	0	0	3	1	1	0	2	2	0	3	2	2	4	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:7578203C>T	uc002gim.2	-	6	840	c.646G>A	c.(646-648)GTG>ATG	p.V216M	TP53_uc002gig.1_Missense_Mutation_p.V216M|TP53_uc002gih.2_Missense_Mutation_p.V216M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V84M|TP53_uc010cng.1_Missense_Mutation_p.V84M|TP53_uc002gii.1_Missense_Mutation_p.V84M|TP53_uc010cnh.1_Missense_Mutation_p.V216M|TP53_uc010cni.1_Missense_Mutation_p.V216M|TP53_uc002gij.2_Missense_Mutation_p.V216M|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.V123M|TP53_uc002gio.2_Missense_Mutation_p.V84M|TP53_uc010vug.1_Missense_Mutation_p.V177M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	216	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> A (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> M (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V216M(49)|p.V216del(8)|p.0?(7)|p.V216L(7)|p.V216E(4)|p.V216G(3)|p.V216A(3)|p.V216fs*6(2)|p.V216fs*31(2)|p.H214fs*5(2)|p.K164_P219del(1)|p.V216fs*32(1)|p.V216fs*33(1)|p.S215fs*27(1)|p.S215fs*29(1)|p.V216fs*5(1)|p.V216_Y220delVVVPY(1)|p.D208_V216delDRNTFRHSV(1)|p.D208fs*1(1)|p.V216fs*28(1)|p.S215fs*31(1)|p.S215_V216insX(1)|p.T211fs*28(1)|p.D207_V216del10(1)|p.S215_V218>R(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACCACCACACTATGTCGA	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			27	10					0	0	0	0	T	7578203	T	T	7578203	3	4	137	1	0	0	0	0	1	0	0	0	16448	478	17	4	648	4	TP53	17	7578203	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	3596974	7578203	73617007	153	24708											
MYH8	4626	broad.mit.edu	37	chr17	10322343	10322343	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttggtcttccctgacagttAgagtctggtgagtaagcaag	9	12	12	8	0	2	3	0	2	2	1	3	3	3	3	1	2	1	3	1	2	3	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:10322343A>G	uc002gmm.2	-	4	310	c.215T>C	c.(214-216)CTA>CCA	p.L72P	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	72	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CCTGACAGTTAGAGTCTGGTG	0.313									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				26	45					0	0	0	0	G	10322343	G	G	10322343	3	3	137	1	0	0	0	0	1	0	0	0	10094	420	15	5	5746	5	MYH8	17	10322343	Missense_Mutation	SNP	A	TCGA-CR-7365-01A-11D-2012-08	2744140	10322343	70872867	154	24709											
FLII	2314	broad.mit.edu	37	chr17	18151261	18151261	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagccgcattcttggcatCagctccaccttgggacgctg	7	9	10	15	2	2	0	1	0	1	0	3	1	3	1	4	2	2	4	4	2	0	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:18151261C>T	uc002gsr.1	-	19	2328	c.2277G>A	c.(2275-2277)CTG>CTA	p.L759L	FLII_uc002gsq.1_Silent_p.L630L|FLII_uc010cpy.1_Silent_p.L748L|FLII_uc010vxn.1_Silent_p.L728L|FLII_uc010vxo.1_Silent_p.L704L|FLII_uc002gss.1_Silent_p.L758L	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	759	Interaction with ACTL6A.|Gelsolin-like 3.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					TTCTTGGCATCAGCTCCACCT	0.617													32	73					0	0	0	0	T	18151261	T	T	18151261	2	4	137	1	0	0	0	0	0	0	0	1	5957	813	29	2		2	FLII	17	18151261	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	7828918	18151261	63043949	155	24710											
SOCS7	30837	broad.mit.edu	37	chr17	36552194	36552194	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgcagctcatttccaaacaGaagcaagaggtggaaccctc	13	6	10	12	1	1	2	1	0	0	2	3	3	2	3	2	2	4	3	2	2	4	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:36552194G>A	uc002hqa.2	+	9	1842	c.1719G>A	c.(1717-1719)CAG>CAA	p.Q573Q	SOCS7_uc010cvl.2_Silent_p.Q539Q|SOCS7_uc002hqb.2_Intron	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	573					intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					TTTCCAAACAGAAGCAAGAGG	0.512													18	31					0	0	0	0	A	36552194	A	A	36552194	2	1	137	1	0	0	0	0	0	0	0	1	14983	933	33	2		2	SOCS7	17	36552194	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	18400933	36552194	44643016	156	24711											
MLLT6	4302	broad.mit.edu	37	chr17	36872785	36872785	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagcagaaggtggtcttctCtggctttgggcccatcatgc	6	12	13	10	0	3	2	1	1	2	1	4	2	3	2	1	4	2	2	1	4	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:36872785C>T	uc002hqi.3	+	10	1215	c.1202C>T	c.(1201-1203)TCT>TTT	p.S401F	MLLT6_uc002hqj.2_Intron|MLLT6_uc002hqk.3_5'Flank	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	401					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					GTGGTCTTCTCTGGCTTTGGG	0.657			T	MLL	AL								30	42					0	0	0	0	T	36872785	T	T	36872785	3	4	137	1	0	0	0	0	1	0	0	0	9683	913	32	2	1240	2	MLLT6	17	36872785	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	320591	36872785	44322425	157	24712											
PGAP3	93210	broad.mit.edu	37	chr17	37840929	37840929	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggcagagcatcaccaggCtggccaggccattgagaaac	12	4	13	12	1	1	2	1	1	0	2	1	3	1	2	3	4	3	3	3	4	1	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:37840929C>T	uc002hsj.2	-	3	396	c.353G>A	c.(352-354)AGC>AAC	p.S118N	PGAP3_uc010cvy.2_RNA|PGAP3_uc010wej.1_Missense_Mutation_p.S118N|PGAP3_uc002hsk.2_Intron|PGAP3_uc010cvz.2_Missense_Mutation_p.S118N	NM_033419	NP_219487	Q96FM1	PGAP3_HUMAN	per1-like domain containing 1 precursor	118	Helical; (Potential).				GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			upper_aerodigestive_tract(1)	1						CATCACCAGGCTGGCCAGGCC	0.602													18	26					0	0	0	0	T	37840929	T	T	37840929	3	4	137	1	0	0	0	0	1	0	0	0	11834	797	28	4	633	4	PGAP3	17	37840929	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	968144	37840929	43354281	158	24713											
NKIRAS2	28511	broad.mit.edu	37	chr17	40174467	40174467	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacgtgggctccattgagAcagaccggggggtgcgagag	8	7	17	9	3	1	3	0	1	1	3	2	5	2	3	2	4	2	1	2	4	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:40174467A>G	uc002hyq.2	+	3	210	c.145A>G	c.(145-147)ACA>GCA	p.T49A	NKIRAS2_uc010wgd.1_Missense_Mutation_p.T49A|NKIRAS2_uc002hyr.2_Missense_Mutation_p.T49A|NKIRAS2_uc002hys.2_Missense_Mutation_p.T49A|NKIRAS2_uc010wge.1_Missense_Mutation_p.T49A|NKIRAS2_uc002hyt.2_Missense_Mutation_p.T49A	NM_001001349	NP_001001349	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2 isoform a	49	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			ovary(1)	1		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				CTCCATTGAGACAGACCGGGG	0.557													27	42					0	0	0	0	G	40174467	G	G	40174467	3	3	137	1	0	0	0	0	1	0	0	0	10499	275	10	5	151	5	NKIRAS2	17	40174467	Missense_Mutation	SNP	A	TCGA-CR-7365-01A-11D-2012-08	2333538	40174467	41020743	159	24714											
GPATCH8	23131	broad.mit.edu	37	chr17	42483420	42483420	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttcagatcttttaatctCtgggttaaaagaaagaaaga	15	13	8	5	0	3	4	1	0	2	4	4	4	3	4	0	1	1	2	0	1	5	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:42483420C>G	uc002igw.1	-	7	557	c.493_splice	c.e7-1	p.R165_splice	GPATCH8_uc002igv.1_Splice_Site_p.R87_splice|GPATCH8_uc010wiz.1_Splice_Site_p.R87_splice	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8							intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CTTTTAATCTCTGGGTTAAAA	0.433													18	29					0	0	0	0	G	42483420	G	G	42483420	5	3	137	1	0	0	0	0	0	0	1	0	6632	927	32	2	4024	2	GPATCH8	17	42483420	Splice_Site	SNP	C	TCGA-CR-7365-01A-11D-2012-08	2308953	42483420	38711790	160	24715											
AKAP1	8165	broad.mit.edu	37	chr17	55182885	55182885	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggatgctggcgctcctCggctggtggtggtttttctc	1	14	15	11	2	1	0	0	0	1	0	4	1	2	1	2	6	1	4	2	6	0	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:55182885C>A	uc002iux.2	+	2	291	c.60C>A	c.(58-60)CTC>CTA	p.L20L	AKAP1_uc010wnl.1_Silent_p.L20L|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Silent_p.L20L	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	20					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					TGGCGCTCCTCGGCTGGTGGT	0.577													22	32					1.87028e-06	1.97646e-06	1	0	A	55182885	A	A	55182885	2	1	137	1	0	0	0	0	0	0	0	1	445	871	31	3		3	AKAP1	17	55182885	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	12699465	55182885	26012325	161	24716											
MED13	9969	broad.mit.edu	37	chr17	60042437	60042437	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaatcccagctgtctgtaGagctgatgtctgttgccctc	8	12	10	11	0	2	3	0	1	2	2	4	3	3	3	2	0	3	4	2	0	2	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:60042437G>C	uc002izo.2	-	20	4851	c.4774C>G	c.(4774-4776)CTA>GTA	p.L1592V		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1592					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GCTGTCTGTAGAGCTGATGTC	0.453													12	41					0	0	0	0	C	60042437	C	C	60042437	3	2	137	1	0	0	0	0	1	0	0	0	9483	933	33	2	1794	2	MED13	17	60042437	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	4859552	60042437	21152773	162	24717											
DNAI2	64446	broad.mit.edu	37	chr17	72308173	72308173	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagacccggcgagagaagaTcctggaggccaggcaccggg	10	3	17	11	3	0	3	0	1	0	3	1	7	1	4	4	5	0	1	4	5	1	0			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:72308173T>A	uc002jkf.2	+	12	1625	c.1526T>A	c.(1525-1527)ATC>AAC	p.I509N	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_5'Flank|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	509					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CGAGAGAAGATCCTGGAGGCC	0.652									Kartagener_syndrome				14	21					0	0	0	0	A	72308173	A	A	72308173	3	1	137	1	0	0	0	0	1	0	0	0	4632	1435	50	5	1568	5	DNAI2	17	72308173	Missense_Mutation	SNP	T	TCGA-CR-7365-01A-11D-2012-08	12265736	72308173	8887037	163	24718											
CDR2L	30850	broad.mit.edu	37	chr17	72997458	72997458	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctaaccaagcagctggacaCgctgcggcacgtgaacgagc	11	4	12	14	4	0	1	0	1	0	0	0	3	0	2	2	2	6	4	2	2	3	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:72997458C>T	uc002jml.3	+	3	627	c.215C>T	c.(214-216)ACG>ATG	p.T72M		NM_014603	NP_055418	Q86X02	CDR2L_HUMAN	cerebellar degeneration-related protein 2-like	72	Potential.										0	all_lung(278;0.226)					CAGCTGGACACGCTGCGGCAC	0.562													6	21					0	0	0	0	T	72997458	T	T	72997458	3	4	137	1	0	0	0	0	1	0	0	0	3188	536	19	1	225	1	CDR2L	17	72997458	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	689285	72997458	8197752	164	24719											
SMAD4	4089	broad.mit.edu	37	chr18	48584552	48584552	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggactgttgcagatagcatCagggcctcagccaggacagc	11	6	13	11	0	2	1	2	0	0	1	2	3	2	3	2	3	4	3	2	3	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr18:48584552C>G	uc010xdp.1	+	6	1263	c.725C>G	c.(724-726)TCA>TGA	p.S242*	SMAD4_uc010xdo.1_RNA|SMAD4_uc002lfb.3_Nonsense_Mutation_p.S87*	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	242					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CAGATAGCATCAGGGCCTCAG	0.433									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				21	14					0	0	0	0	G	48584552	G	G	48584552	4	3	137	1	0	0	0	0	0	1	0	0	14824	838	29	2	743	2	SMAD4	18	48584552	Nonsense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08		48584552	29492696	165	24720											
APBA3	9546	broad.mit.edu	37	chr19	3759797	3759797	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgctcagcagaggccccctCcacccattctggggagtcag	7	7	11	16	0	3	1	2	0	1	1	4	2	4	2	4	3	2	2	4	3	0	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:3759797C>G	uc002lyp.1	-	2	643	c.466G>C	c.(466-468)GAG>CAG	p.E156Q	MRPL54_uc002lyq.3_5'Flank	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	156					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGCCCCCTCCACCCATTCT	0.642													10	33					0	0	0	0	G	3759797	G	G	3759797	3	3	137	1	0	0	0	0	1	0	0	0	758	864	30	2	1301	2	APBA3	19	3759797	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08		3759797	55369186	166	24721											
GDF1	2657	broad.mit.edu	37	chr19	18990068	18990068	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaggaaccagtagaggttCataagggtgagcagcagcag	14	5	14	8	0	1	2	1	1	0	1	1	3	1	3	2	3	4	5	2	3	3	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:18990068C>T	uc002nki.1	-	5	954	c.882G>A	c.(880-882)ATG>ATA	p.M294I	LASS1_uc002nkj.2_Missense_Mutation_p.M294I|LASS1_uc010ebx.2_Missense_Mutation_p.M196I	NM_021267	NP_067090	P27539	GDF1_HUMAN	LAG1 homolog, ceramide synthase 1 isoform 1	Error:Variant_position_missing_in_P27539_after_alignment					growth	extracellular space	cytokine activity|growth factor activity				0						AGTAGAGGTTCATAAGGGTGA	0.612													4	27					0	0	0	0	T	18990068	T	T	18990068	3	4	137	1	0	0	0	0	1	0	0	0	6347	826	29	2		2	GDF1	19	18990068	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	15230271	18990068	40138915	167	24722											
ZNF254	9534	broad.mit.edu	37	chr19	24309211	24309211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagtataaggtgaacaaaGaaggttataatggacttaac	18	10	10	3	0	0	3	0	2	0	1	0	4	0	4	0	3	2	2	0	3	8	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:24309211G>A	uc002nru.2	+	4	543	c.409G>A	c.(409-411)GAA>AAA	p.E137K	ZNF254_uc010xrk.1_Missense_Mutation_p.E52K	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	137					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				GGTGAACAAAGAAGGTTATAA	0.299													23	34					0	0	0	0	A	24309211	A	A	24309211	3	1	137	1	0	0	0	0	1	0	0	0	17865	943	33	2	423	2	ZNF254	19	24309211	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	5319143	24309211	34819772	168	24723											
MAG	4099	broad.mit.edu	37	chr19	35790470	35790470	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtatagacacccccaacatCgtggtgcccccagaggtggt	9	7	11	14	2	0	2	0	0	0	2	1	2	0	2	4	3	2	1	4	3	3	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:35790470C>T	uc002nyy.1	+	5	578	c.429C>T	c.(427-429)ATC>ATT	p.I143I	MAG_uc002nyx.1_Silent_p.I143I|MAG_uc010eds.1_Silent_p.I118I|MAG_uc002nyz.1_Silent_p.I143I	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	143	Ig-like C2-type 1.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCCCCAACATCGTGGTGCCCC	0.672													3	19					0	0	0	0	T	35790470	T	T	35790470	2	4	137	1	0	0	0	0	0	0	0	1	9213	874	31	1		1	MAG	19	35790470	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	11481259	35790470	23338513	169	24724											
HSD17B14	51171	broad.mit.edu	37	chr19	49316972	49316972	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggccaaagctttggtcaTggctgttactgccccctgca	7	10	11	13	0	1	0	1	0	0	0	1	0	1	0	3	3	4	4	3	3	2	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:49316972T>C	uc002pkv.1	-	7	756	c.490A>G	c.(490-492)ATG>GTG	p.M164V	BCAT2_uc002pkq.3_5'Flank|BCAT2_uc002pkr.2_5'Flank|BCAT2_uc002pks.2_5'Flank|BCAT2_uc002pkt.2_5'Flank|BCAT2_uc010emh.1_5'Flank|BCAT2_uc010emi.1_5'Flank|BCAT2_uc010emj.1_5'Flank|HSD17B14_uc010emk.1_Missense_Mutation_p.M164V	NM_016246	NP_057330	Q9BPX1	DHB14_HUMAN	dehydrogenase/reductase (SDR family) member 10	164					steroid catabolic process	centrosome|cytosol	estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity				0		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000341)|all cancers(93;0.000764)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.0346)		GCTTTGGTCATGGCTGTTACT	0.612													41	58					0	0	0	0	C	49316972	C	C	49316972	3	2	137	1	0	0	0	0	1	0	0	0	7422	1464	51	5	334	5	HSD17B14	19	49316972	Missense_Mutation	SNP	T	TCGA-CR-7365-01A-11D-2012-08	13526502	49316972	9812011	170	24725											
CPT1C	126129	broad.mit.edu	37	chr19	50204760	50204760	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cttctcccctttagtacctgGagtcggtccggcccatcctc	4	12	8	17	2	1	0	0	0	1	0	6	1	3	1	6	3	1	1	6	3	2	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:50204760G>C	uc002ppj.2	+	6	767	c.562G>C	c.(562-564)GAG>CAG	p.E188Q	CPT1C_uc002ppl.3_Missense_Mutation_p.E154Q|CPT1C_uc002ppi.2_Missense_Mutation_p.E105Q|CPT1C_uc002ppk.2_Missense_Mutation_p.E188Q|CPT1C_uc010eng.2_Missense_Mutation_p.E188Q|CPT1C_uc010enh.2_Missense_Mutation_p.E188Q|CPT1C_uc010ybc.1_Missense_Mutation_p.E26Q	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	188	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTAGTACCTGGAGTCGGTCCG	0.577													14	32					0	0	0	0	C	50204760	C	C	50204760	3	2	137	1	0	0	0	0	1	0	0	0	3848	1175	41	2	580	2	CPT1C	19	50204760	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	887788	50204760	8924223	171	24726											
PTOV1	53635	broad.mit.edu	37	chr19	50361359	50361359	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtacatgcagctcatcccGcagcagctgctggtgagggg	7	8	14	12	1	1	1	1	1	0	0	2	1	2	1	1	3	6	7	1	3	1	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:50361359G>A	uc002pqf.1	+	9	1094	c.924G>A	c.(922-924)CCG>CCA	p.P308P	PTOV1_uc002ppz.3_RNA|PTOV1_uc002pqb.3_Silent_p.P276P|PTOV1_uc002pqa.2_RNA|PTOV1_uc002pqc.1_RNA|PTOV1_uc002pqd.2_RNA|PTOV1_uc002pqe.1_RNA	NM_017432	NP_059128	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	308	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		AGCTCATCCCGCAGCAGCTGC	0.687													12	30					0	0	0	0	A	50361359	A	A	50361359	2	1	137	1	0	0	0	0	0	0	0	1	12832	1074	38	1		1	PTOV1	19	50361359	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	156599	50361359	8767624	172	24727											
PNKP	11284	broad.mit.edu	37	chr19	50368399	50368399	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaccttgccctggggtttCaccccagctgcggtgaacac	6	9	10	16	1	2	1	2	1	0	0	2	1	2	1	4	3	4	2	4	3	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:50368399C>T	uc002pqh.2	-	3	535	c.483G>A	c.(481-483)GTG>GTA	p.V161V	PNKP_uc002pqg.2_5'UTR|PNKP_uc002pqi.2_Silent_p.V122V|PNKP_uc002pqj.2_Silent_p.V161V|PNKP_uc010enm.2_Silent_p.V161V|PNKP_uc002pqk.2_Silent_p.V161V	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	161					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		CCTGGGGTTTCACCCCAGCTG	0.552								Other_BER_factors					5	21					0	0	0	0	T	50368399	T	T	50368399	2	4	137	1	0	0	0	0	0	0	0	1	12202	813	29	2		2	PNKP	19	50368399	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	7040	50368399	8760584	173	24728											
ZFP28	140612	broad.mit.edu	37	chr19	57061542	57061542	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggagaacaacagtgacctggGatcagcaggtaaggatgtcc	13	6	14	8	0	1	2	1	1	0	1	2	5	2	4	2	4	3	2	2	4	3	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:57061542G>T	uc002qnj.2	+	6	865	c.794G>T	c.(793-795)GGA>GTA	p.G265V	ZFP28_uc002qni.2_Missense_Mutation_p.G265V|uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	265	KRAB 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		AGTGACCTGGGATCAGCAGGT	0.478													5	9					3.59834e-05	3.78608e-05	1	0	T	57061542	T	T	57061542	3	4	137	1	0	0	0	0	1	0	0	0	17709	1174	41	2	816	2	ZFP28	19	57061542	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	6693143	57061542	2067441	174	24729											
ZNF835	90485	broad.mit.edu	37	chr19	57174961	57174961	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccctcagctcttaatcttCtgctggtccacgcgggtttc	4	13	10	14	2	4	0	1	0	3	0	6	0	5	0	2	3	2	3	2	3	1	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:57174961C>G	uc010ygo.1	-	2	1672	c.1672G>C	c.(1672-1674)GAA>CAA	p.E558Q	ZNF835_uc010ygn.1_Missense_Mutation_p.E536Q	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						TCTTAATCTTCTGCTGGTCCA	0.388													27	31					0	0	0	0	G	57174961	G	G	57174961	3	3	137	1	0	0	0	0	1	0	0	0	18253	922	32	2	9	2	ZNF835	19	57174961	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	113419	57174961	1954022	175	24730											
ZIK1	284307	broad.mit.edu	37	chr19	58102361	58102361	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagtcaaaaagctaccctCattaaacaccagagagttca	16	10	5	10	0	3	1	3	0	0	1	3	2	3	1	2	0	3	2	2	0	6	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:58102361C>A	uc002qpg.2	+	4	1279	c.1182C>A	c.(1180-1182)CTC>CTA	p.L394L	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Silent_p.L339L|ZIK1_uc002qpi.2_Silent_p.L381L|ZIK1_uc002qpj.2_Silent_p.L291L	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	394	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAGCTACCCTCATTAAACACC	0.438													26	43					1.85244e-09	2.0013e-09	1	0	A	58102361	A	A	58102361	2	1	137	1	0	0	0	0	0	0	0	1	17750	813	29	2		2	ZIK1	19	58102361	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08	927400	58102361	1026622	176	24731											
A1BG	1	broad.mit.edu	37	chr19	58863922	58863922	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagggagcaggcaaggactCtgtgggtggggtggagttga	8	7	20	6	0	1	1	0	1	1	0	1	4	1	4	1	7	1	3	1	7	1	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:58863922C>T	uc002qsd.3	-	4	403	c.341_splice	c.e4-1	p.K114_splice	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_Splice_Site|NCRNA00181_uc002qsg.2_RNA	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor							extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		GGCAAGGACTCTGTGGGTGGG	0.602													16	115					0	0	0	0	T	58863922	T	T	58863922	5	4	137	1	0	0	0	0	0	0	1	0	1	927	32	2	1167	2	A1BG	19	58863922	Splice_Site	SNP	C	TCGA-CR-7365-01A-11D-2012-08	761561	58863922	265061	177	24732											
RALGAPA2	57186	broad.mit.edu	37	chr20	20621406	20621407	+	Frame_Shift_Ins	INS	-	A	A																															tgcaagggcccctggatgacINSatgactgctgggaaaccagg																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:20621406_20621407insA	uc002wrz.2	-	6	631_632	c.488_489insT	c.(487-489)ATGfs	p.M163fs	RALGAPA2_uc010zsg.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	163					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						CCCTGGATGACATGACTGCTGG	0.485													---	---	---								A	20621407	A	A	20621406	7	5	137	1	0	1	1	0	0	0	0	0	13079	478	17	0	5268	0	RALGAPA2	20	20621406	Frame_Shift_Ins	INS	-	TCGA-CR-7365-01A-11D-2012-08		20621406	42404114	178	24733											
CBFA2T2	9139	broad.mit.edu	37	chr20	32232451	32232451	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatcgacaccaacggactctGagccccggactctgcttacc	9	8	8	16	3	2	1	0	1	2	0	3	4	2	3	4	2	4	1	4	2	3	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:32232451G>A	uc002wzg.1	+	12	2351	c.1814G>A	c.(1813-1815)TGA>TAA	p.*605*	CBFA2T2_uc010zug.1_Silent_p.*379*|CBFA2T2_uc002wze.1_Silent_p.*596*|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Silent_p.*576*|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA|CBFA2T2_uc002wzk.1_Silent_p.*153*	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	605						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						AACGGACTCTGAGCCCCGGAC	0.607													33	99					0	0	0	0	A	32232451	A	A	32232451	2	1	137	1	0	0	0	0	0	0	0	1	2709	1285	45	2		2	CBFA2T2	20	32232451	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	11611045	32232451	30793069	179	24734											
EPB41L1	2036	broad.mit.edu	37	chr20	34761727	34761727	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagacaggccccgactctGaggtgaagaaagctcaggag	13	4	14	10	1	2	4	1	2	1	2	2	7	2	5	2	3	1	1	2	3	2	0			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:34761727G>A	uc002xfb.2	+	2	199	c.28G>A	c.(28-30)GAG>AAG	p.E10K	EPB41L1_uc002xeu.2_Intron|EPB41L1_uc010zvo.1_Missense_Mutation_p.E10K|EPB41L1_uc002xev.2_Missense_Mutation_p.E10K|EPB41L1_uc002xew.2_Intron|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Missense_Mutation_p.E10K|EPB41L1_uc002xez.2_Intron	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	10					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					CCCCGACTCTGAGGTGAAGAA	0.627													20	69					0	0	0	0	A	34761727	A	A	34761727	3	1	137	1	0	0	0	0	1	0	0	0	5176	1291	45	2	30	2	EPB41L1	20	34761727	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	2529276	34761727	28263793	180	24735											
RIMS4	140730	broad.mit.edu	37	chr20	43385614	43385614	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggtccagcgacttgcgagcGactttggtcttcttcttggc	4	13	13	11	3	3	0	0	0	3	0	4	3	4	0	1	3	3	0	1	3	0	5			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:43385614G>A	uc002xms.2	-	5	516	c.516C>T	c.(514-516)GTC>GTT	p.V172V	RIMS4_uc010ggu.2_Silent_p.V173V	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	172	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				ACTTGCGAGCGACTTTGGTCT	0.562													117	361					0	0	0	0	A	43385614	A	A	43385614	2	1	137	1	0	0	0	0	0	0	0	1	13435	1045	37	1		1	RIMS4	20	43385614	Silent	SNP	G	TCGA-CR-7365-01A-11D-2012-08	8623887	43385614	19639906	181	24736											
ELMO2	63916	broad.mit.edu	37	chr20	44999107	44999107	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtttcagagcacttttcTctttcatgtggggacaatct	7	17	8	9	0	5	1	2	0	3	1	6	2	5	2	0	2	1	2	0	2	1	4			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:44999107T>C	uc002xrt.1	-	20	2069	c.1859A>G	c.(1858-1860)GAG>GGG	p.E620G	ELMO2_uc010zxq.1_Missense_Mutation_p.E352G|ELMO2_uc002xrs.1_Missense_Mutation_p.E367G|ELMO2_uc002xru.1_Missense_Mutation_p.E620G|ELMO2_uc010zxr.1_Missense_Mutation_p.E632G|ELMO2_uc010zxs.1_Missense_Mutation_p.E437G|ELMO2_uc002xrv.1_Missense_Mutation_p.E339G	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	620	PH.				apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				AGCACTTTTCTCTTTCATGTG	0.458													27	107					0	0	0	0	C	44999107	C	C	44999107	3	2	137	1	0	0	0	0	1	0	0	0	5090	1551	54	5	315	5	ELMO2	20	44999107	Missense_Mutation	SNP	T	TCGA-CR-7365-01A-11D-2012-08	1613493	44999107	18026413	182	24737											
ITSN1	6453	broad.mit.edu	37	chr21	35208792	35208792	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaccgcgcagaatgacgatGagctggccttcaacaagggc	12	5	12	12	3	1	3	1	2	0	1	1	4	1	3	2	2	2	2	2	2	3	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr21:35208792G>C	uc002yta.1	+	29	3785	c.3517G>C	c.(3517-3519)GAG>CAG	p.E1173Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E1097Q|ITSN1_uc010gmg.2_Missense_Mutation_p.E1060Q|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E1173Q|ITSN1_uc010gmi.2_Missense_Mutation_p.E1136Q|ITSN1_uc010gmj.2_Missense_Mutation_p.E1052Q|ITSN1_uc002ysy.2_Missense_Mutation_p.E1168Q|ITSN1_uc002ysx.2_Missense_Mutation_p.E1131Q|ITSN1_uc002ytb.1_Missense_Mutation_p.E1168Q|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E1065Q|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E1168Q|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E1036Q|ITSN1_uc002yti.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1173	SH3 5.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						GAATGACGATGAGCTGGCCTT	0.572													19	26					0	0	0	0	C	35208792	C	C	35208792	3	2	137	1	0	0	0	0	1	0	0	0	7965	1291	45	2	3627	2	ITSN1	21	35208792	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08		35208792	12921103	183	24738											
NPTXR	23467	broad.mit.edu	37	chr22	39222541	39222541	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctccatgggctcatggccCgcctctagcagtacaatctc	8	9	9	15	1	3	0	1	0	2	0	5	0	4	0	3	2	3	4	3	2	3	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr22:39222541C>T	uc003awk.2	-	3	1216	c.1062G>A	c.(1060-1062)GCG>GCA	p.A354A		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	354	Pentaxin.|Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					GCTCATGGCCCGCCTCTAGCA	0.667													15	95					0	0	0	0	T	39222541	T	T	39222541	2	4	137	1	0	0	0	0	0	0	0	1	10658	639	23	1		1	NPTXR	22	39222541	Silent	SNP	C	TCGA-CR-7365-01A-11D-2012-08		39222541	12082025	184	24739											
POLDIP3	84271	broad.mit.edu	37	chr22	42981957	42981957	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgctctcctttttcattgatGggctgtcactcagccgcctg	4	14	9	14	2	4	1	3	1	1	0	5	1	4	1	3	1	1	2	3	1	0	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr22:42981957G>T	uc003bcu.2	-	9	1205	c.1106C>A	c.(1105-1107)CCA>CAA	p.P369Q	POLDIP3_uc011app.1_3'UTR|POLDIP3_uc003bcv.2_Missense_Mutation_p.P340Q|POLDIP3_uc011apq.1_Missense_Mutation_p.P386Q|POLDIP3_uc010gza.2_RNA|POLDIP3_uc011apr.1_RNA|POLDIP3_uc010gzb.1_Intron	NM_032311	NP_115687	Q9BY77	PDIP3_HUMAN	DNA polymerase delta interacting protein 3	369					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding				0						TTTCATTGATGGGCTGTCACT	0.488													7	35					8.12818e-05	8.51524e-05	1	0	T	42981957	T	T	42981957	3	4	137	1	0	0	0	0	1	0	0	0	12250	1348	47	4	163	4	POLDIP3	22	42981957	Missense_Mutation	SNP	G	TCGA-CR-7365-01A-11D-2012-08	3759416	42981957	8322609	185	24740											
BEND2	139105	broad.mit.edu	37	chrX	18183158	18183158	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggtcagtggcgtcgggatCtcctggctttgactcctgct	3	13	14	11	2	2	1	1	1	1	0	5	2	3	2	2	4	1	2	2	4	0	1			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:18183158C>G	uc004cyj.3	-	14	2525	c.2371G>C	c.(2371-2373)GAT>CAT	p.D791H		NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	791										ovary(3)|kidney(1)|central_nervous_system(1)	5						GCGTCGGGATCTCCTGGCTTT	0.478													64	43					0	0	0	0	G	18183158	G	G	18183158	3	3	137	1	0	0	0	0	1	0	0	0	1400	913	32	2	32	2	BEND2	23	18183158	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08		18183158	137087402	186	24741											
ZNF182	7569	broad.mit.edu	37	chrX	47837109	47837109	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttggtgataattgttttcTtgtcagaaaatccaacttgc	10	17	7	7	0	3	2	1	1	2	1	4	2	4	2	1	1	2	1	1	1	4	7			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:47837109T>C	uc004dir.2	-	7	723	c.377A>G	c.(376-378)AAG>AGG	p.K126R	ZNF182_uc004dis.2_Missense_Mutation_p.K107R|ZNF182_uc004dit.2_Missense_Mutation_p.K126R|ZNF182_uc011mlu.1_Missense_Mutation_p.K106R	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						AATTGTTTTCTTGTCAGAAAA	0.383													14	8					0	0	0	0	C	47837109	C	C	47837109	3	2	137	1	0	0	0	0	1	0	0	0	17817	1609	56	5	1546	5	ZNF182	23	47837109	Missense_Mutation	SNP	T	TCGA-CR-7365-01A-11D-2012-08	29653951	47837109	107433451	187	24742											
HUWE1	10075	broad.mit.edu	37	chrX	53560308	53560308	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttcagagcactcctggatagCcaacagtagcatgtggcgga	11	8	12	10	1	1	1	1	0	0	1	2	3	2	3	2	3	4	3	2	3	3	3			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:53560308C>A	uc004dsp.2	-	84	13489	c.13087G>T	c.(13087-13089)GCT>TCT	p.A4363S	HUWE1_uc004dsn.2_Missense_Mutation_p.A3171S	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4363	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCCTGGATAGCCAACAGTAGC	0.512													8	5					0.000157383	0.000163462	1	0	A	53560308	A	A	53560308	3	1	137	1	0	0	0	0	1	0	0	0	7500	739	26	4	41	4	HUWE1	23	53560308	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	5723199	53560308	101710252	188	24743											
HUWE1	10075	broad.mit.edu	37	chrX	53589155	53589155	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttactgccactgctgtcctCttcctgagtgtgctcctcct	3	15	8	15	0	1	1	0	1	1	0	5	1	5	1	5	0	4	3	5	0	1	2			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:53589155C>T	uc004dsp.2	-	54	7657	c.7255G>A	c.(7255-7257)GAG>AAG	p.E2419K	HUWE1_uc004dsn.2_Missense_Mutation_p.E1243K	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2419	Glu-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CTGCTGTCCTCTTCCTGAGTG	0.403													17	12					0	0	0	0	T	53589155	T	T	53589155	3	4	137	1	0	0	0	0	1	0	0	0	7500	922	32	2	5993	2	HUWE1	23	53589155	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	28847	53589155	101681405	189	24744											
PCDH19	57526	broad.mit.edu	37	chrX	99657785	99657785	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccggggtaccaggcggatgtCattcttactgatttttttct	6	16	10	9	2	3	1	1	1	2	0	3	2	3	2	2	4	2	1	2	4	2	6			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:99657785C>G	uc010nmz.2	-	3	4029	c.2353G>C	c.(2353-2355)GAC>CAC	p.D785H	PCDH19_uc004efw.3_Missense_Mutation_p.D738H|PCDH19_uc004efx.3_Missense_Mutation_p.D738H	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	785	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						AGGCGGATGTCATTCTTACTG	0.448													10	14					0	0	0	0	G	99657785	G	G	99657785	3	3	137	1	0	0	0	0	1	0	0	0	11568	826	29	2	1109	2	PCDH19	23	99657785	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	46068630	99657785	55612775	190	24745											
NKAP	79576	broad.mit.edu	37	chrX	119066103	119066103	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagggattttccagaaactCttcttgggattctttagagc	9	14	9	9	0	3	2	0	0	3	2	4	4	4	4	2	2	2	0	2	2	2	7			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:119066103C>G	uc004esh.2	-	6	981	c.814G>C	c.(814-816)GAG>CAG	p.E272Q	NKAP_uc004esg.2_Missense_Mutation_p.E159Q	NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	272	Necessary for interaction with CIR1.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						TCCAGAAACTCTTCTTGGGAT	0.353													74	51					0	0	0	0	G	119066103	G	G	119066103	3	3	137	1	0	0	0	0	1	0	0	0	10493	922	32	2	449	2	NKAP	23	119066103	Missense_Mutation	SNP	C	TCGA-CR-7365-01A-11D-2012-08	19408318	119066103	36204457	191	24746											
FLNA	2316	broad.mit.edu	37	chrX	153580304	153580305	+	Frame_Shift_Del	DEL	AA	-	-																															gagccgtccttgcggtcctcAaaagagatctcagccttgct																										TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:153580304_153580305delAA	uc004fkk.2	-	42	7103_7104	c.6854_6855delTT	c.(6853-6855)TTTfs	p.F2285fs	FLNA_uc004fki.2_Frame_Shift_Del_p.F328fs|FLNA_uc011mzn.1_Frame_Shift_Del_p.F418fs|FLNA_uc010nuu.1_Frame_Shift_Del_p.F2277fs	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2285	Filamin 21.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGCGGTCCTCAAAAGAGATCTC	0.619													---	---	---								-	153580305	-	-	153580304	7	5	137	1	0	1	0	1	0	0	0	0	5965	127	5	0	1116	0	FLNA	23	153580304	Frame_Shift_Del	DEL	AA	TCGA-CR-7365-01A-11D-2012-08	34514201	153580304	1690256	192	24747											
TAS1R1	80835	broad.mit.edu	37	chr1	6635143	6635143	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtgcccgggatccagcgCattgggatggtgctgggcgt	4	8	20	9	3	0	0	0	0	0	0	1	2	1	2	2	6	3	2	2	6	0	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:6635143C>T	uc001ant.2	+	3	951	c.951C>T	c.(949-951)CGC>CGT	p.R317R	TAS1R1_uc001anu.2_Intron|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_Silent_p.R317R	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	317	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		GGATCCAGCGCATTGGGATGG	0.642													10	32					0	0	0	0	T	6635143	T	T	6635143	2	4	138	1	0	0	0	0	0	0	0	1	15628	697	25	4		4	TAS1R1	1	6635143	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08		6635143	242615478	1	24748											
VPS13D	55187	broad.mit.edu	37	chr1	12326995	12326995	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcctcgttgctttcagtccGgttgggtggactgtttcttc	2	18	11	10	2	2	0	1	0	1	0	6	1	4	1	2	3	1	4	2	3	0	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:12326995G>A	uc001atv.2	+	14	1793	c.1652G>A	c.(1651-1653)CGG>CAG	p.R551Q	VPS13D_uc001atw.2_Missense_Mutation_p.R551Q	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	551					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CTTTCAGTCCGGTTGGGTGGA	0.388													16	35					0	0	0	0	A	12326995	A	A	12326995	3	1	138	1	0	0	0	0	1	0	0	0	17260	1116	39	1	1702	1	VPS13D	1	12326995	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	5691852	12326995	236923626	2	24749											
HNRNPR	10236	broad.mit.edu	37	chr1	23637236	23637241	+	In_Frame_Del	DEL	GGTCCC	-	-																															cacccctagagcctcttggtGgtcccaaaggtgcccccctc																										TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:23637236_23637241delGGTCCC	uc001bgr.3	-	11	1767_1772	c.1608_1613delGGGACC	c.(1606-1614)TTGGGACCA>TTA	p.GP537del	HNRNPR_uc001bgo.2_In_Frame_Del_p.GP147del|HNRNPR_uc001bgp.3_In_Frame_Del_p.GP540del|HNRNPR_uc009vqk.2_In_Frame_Del_p.GP439del|HNRNPR_uc001bgs.3_In_Frame_Del_p.GP436del|HNRNPR_uc010odw.1_In_Frame_Del_p.GP499del|HNRNPR_uc010odx.1_In_Frame_Del_p.GP377del|HNRNPR_uc009vql.2_In_Frame_Del_p.GP398del	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	537_538	RNA-binding RGG-box.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		GCCTCTTGGTGGTCCCAAAGGTGCCC	0.568													---	---	---								-	23637241	-	-	23637236	7	5	138	1	0	1	0	1	0	0	0	0	7311	1348	47	0	292	0	HNRNPR	1	23637236	In_Frame_Del	DEL	GGTCCC	TCGA-CR-7367-01A-11D-2012-08	11310241	23637236	225613385	3	24750											
TMEM39B	55116	broad.mit.edu	37	chr1	32557499	32557499	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgtcacccagcctcatcCgcagtgaggtggagttcctc	6	9	11	15	1	2	1	2	1	0	0	5	2	4	2	5	2	1	2	5	2	0	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:32557499C>T	uc010ogv.1	+	6	960	c.814C>T	c.(814-816)CGC>TGC	p.R272C	TMEM39B_uc010ogt.1_RNA|TMEM39B_uc010ogu.1_Missense_Mutation_p.R145C|TMEM39B_uc001bue.3_Missense_Mutation_p.R273C|TMEM39B_uc001buf.3_Missense_Mutation_p.R73C|TMEM39B_uc010ogw.1_Missense_Mutation_p.R73C	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	272						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CAGCCTCATCCGCAGTGAGGT	0.597													5	49					0	0	0	0	T	32557499	T	T	32557499	3	4	138	1	0	0	0	0	1	0	0	0	16228	652	23	1	836	1	TMEM39B	1	32557499	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	8920263	32557499	216693122	4	24751											
ELAVL4	1996	broad.mit.edu	37	chr1	50666696	50666696	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacaacgtaaaggtgattcGtgacttcaacaccaacaagt	16	8	8	9	2	1	2	1	2	0	0	2	3	1	2	1	1	4	1	1	1	7	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:50666696G>A	uc001csb.2	+	7	1257	c.989G>A	c.(988-990)CGT>CAT	p.R330H	ELAVL4_uc001cry.3_Missense_Mutation_p.R319H|ELAVL4_uc001crz.3_Missense_Mutation_p.R316H|ELAVL4_uc001csa.3_Missense_Mutation_p.R333H|ELAVL4_uc001csc.3_Missense_Mutation_p.R316H|ELAVL4_uc010omz.1_Missense_Mutation_p.R321H	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	330	RRM 3.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						AAGGTGATTCGTGACTTCAAC	0.542													10	68					0	0	0	0	A	50666696	A	A	50666696	3	1	138	1	0	0	0	0	1	0	0	0	5076	1145	40	1	1114	1	ELAVL4	1	50666696	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	18109197	50666696	198583925	5	24752											
C1orf177	163747	broad.mit.edu	37	chr1	55282673	55282673	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttgcagaacccagtaggTgtgggccgctacctcaacac	9	8	11	13	1	1	1	1	0	0	1	1	1	1	1	3	2	4	4	3	2	4	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:55282673T>A	uc001cyb.3	+	9	1116	c.1062T>A	c.(1060-1062)GGT>GGA	p.G354G	C1orf177_uc001cya.3_Silent_p.G354G	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	354											0						ACCCAGTAGGTGTGGGCCGCT	0.572													6	40					0	0	0	0	A	55282673	A	A	55282673	2	1	138	1	0	0	0	0	0	0	0	1	2026	1683	59	5		5	C1orf177	1	55282673	Silent	SNP	T	TCGA-CR-7367-01A-11D-2012-08	4615977	55282673	193967948	6	24753											
C8A	731	broad.mit.edu	37	chr1	57351627	57351627	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttcacaagaatcttcacaAaggtgcagactgcacatttt	13	13	6	9	0	3	2	2	0	1	2	3	2	3	2	0	1	2	2	0	1	3	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:57351627A>T	uc001cyo.2	+	7	1015	c.883A>T	c.(883-885)AAG>TAG	p.K295*		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	295	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						AATCTTCACAAAGGTGCAGAC	0.368													20	29					0	0	0	0	T	57351627	T	T	57351627	4	4	138	1	0	0	0	0	0	1	0	0	2427	15	1	5	909	5	C8A	1	57351627	Nonsense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	2068954	57351627	191898994	7	24754											
DAB1	1600	broad.mit.edu	37	chr1	57611078	57611078	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctttaaacctctttatcAaagtggcttcactgcgatcc	10	13	5	13	1	3	0	2	0	1	0	4	1	4	0	3	1	2	1	3	1	4	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:57611078A>G	uc001cys.1	-	5	766	c.92T>C	c.(91-93)TTG>TCG	p.L31S	DAB1_uc001cyt.1_Missense_Mutation_p.L31S|DAB1_uc001cyq.1_Missense_Mutation_p.L31S|DAB1_uc001cyr.1_Missense_Mutation_p.L31S|DAB1_uc009vzw.1_Missense_Mutation_p.L31S|DAB1_uc009vzx.1_Missense_Mutation_p.L31S	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	31					cell differentiation|nervous system development					skin(2)|ovary(1)	3						CCTCTTTATCAAAGTGGCTTC	0.443													5	47					0	0	0	0	G	57611078	G	G	57611078	3	3	138	1	0	0	0	0	1	0	0	0	4234	131	5	5	1623	5	DAB1	1	57611078	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	259451	57611078	191639543	8	24755											
COL24A1	255631	broad.mit.edu	37	chr1	86529426	86529426	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggaagtcctgggagtccaGgatgtcctttgagaccctgt	7	11	13	10	0	0	1	0	1	0	1	3	5	3	4	4	3	0	0	4	3	1	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:86529426G>C	uc001dlj.2	-	8	1766	c.1724C>G	c.(1723-1725)CCT>CGT	p.P575R	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.P575R	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	575	Collagen-like 2.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TGGGAGTCCAGGATGTCCTTT	0.383													20	103					0	0	0	0	C	86529426	C	C	86529426	3	2	138	1	0	0	0	0	1	0	0	0	3698	1000	35	4	3632	4	COL24A1	1	86529426	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	28918348	86529426	162721195	9	24756											
COL11A1	1301	broad.mit.edu	37	chr1	103491099	103491099	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catttgtcccagaaacatgcCtaggagcttctgtctggtaa	10	12	9	10	0	2	1	0	0	2	1	3	2	3	2	2	2	3	2	2	2	3	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:103491099C>T	uc001dul.2	-	7	1286	c.968G>A	c.(967-969)AGG>AAG	p.R323K	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.R335K|COL11A1_uc001dun.2_Missense_Mutation_p.R284K|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	323	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGAAACATGCCTAGGAGCTTC	0.328													6	47					0	0	0	0	T	103491099	T	T	103491099	3	4	138	1	0	0	0	0	1	0	0	0	3682	681	24	4	4696	4	COL11A1	1	103491099	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	16961673	103491099	145759522	10	24757											
AMY2B	280	broad.mit.edu	37	chr1	104115869	104115869	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggagatatcgagaactacaAtgatgctactcaggtaaatt	15	11	9	6	1	1	3	1	1	0	2	2	5	1	3	0	2	4	2	0	2	7	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:104115869A>G	uc001duq.2	+	5	1116	c.500A>G	c.(499-501)AAT>AGT	p.N167S	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.N167S|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	167					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GAGAACTACAATGATGCTACT	0.358													43	352					0	0	0	0	G	104115869	G	G	104115869	3	3	138	1	0	0	0	0	1	0	0	0	595	101	4	5	510	5	AMY2B	1	104115869	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	624770	104115869	145134752	11	24758											
HSD3B2	3284	broad.mit.edu	37	chr1	119962178	119962178	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttggtgtcactcacagaGagtccatcatgaatgtcaat	11	13	8	9	0	5	2	4	1	1	1	6	3	6	2	1	1	0	0	1	1	2	1	rs6211	byFrequency	TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:119962178G>A	uc001ehs.2	+	2	1053	c.280G>A	c.(280-282)GAG>AAG	p.E94K	HSD3B2_uc001eht.2_Missense_Mutation_p.E94K|HSD3B2_uc001ehu.2_Missense_Mutation_p.E94K	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	94				HRE -> RRQ (in Ref. 8; AAD14329).	androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CACTCACAGAGAGTCCATCAT	0.463													6	56					0	0	0	0	A	119962178	A	A	119962178	3	1	138	1	0	0	0	0	1	0	0	0	7430	943	33	2	286	2	HSD3B2	1	119962178	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	15846309	119962178	129288443	12	24759											
PIAS3	10401	broad.mit.edu	37	chr1	145581554	145581554	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggctccctatgaatctcttAtcattgatgggtagggccat	9	13	10	9	0	2	2	1	2	1	0	4	2	3	2	2	3	0	2	2	3	4	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:145581554A>G	uc001eoc.1	+	9	1226	c.1135A>G	c.(1135-1137)ATC>GTC	p.I379V	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_Missense_Mutation_p.I48V	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	379	SP-RING-type.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGAATCTCTTATCATTGATGG	0.388													14	89					0	0	0	0	G	145581554	G	G	145581554	3	3	138	1	0	0	0	0	1	0	0	0	11932	449	16	5	1169	5	PIAS3	1	145581554	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	25619376	145581554	103669067	13	24760											
THEM5	284486	broad.mit.edu	37	chr1	151824868	151824868	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtacaggctcagcatgtccGaacaccagctggcattggga	10	7	13	11	1	1	0	1	0	0	0	2	2	2	1	2	4	4	5	2	4	2	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:151824868G>A	uc009wnd.2	-	2	323	c.191C>T	c.(190-192)TCG>TTG	p.S64L		NM_182578	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	64							hydrolase activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CAGCATGTCCGAACACCAGCT	0.493													20	117					0	0	0	0	A	151824868	A	A	151824868	3	1	138	1	0	0	0	0	1	0	0	0	15925	1059	37	1	572	1	THEM5	1	151824868	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	6243314	151824868	97425753	14	24761											
FCRL6	343413	broad.mit.edu	37	chr1	159785428	159785428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctccaagaaccccttagcGactgtgaggaggttctctgc	8	10	10	13	1	2	2	0	1	2	1	4	4	2	3	3	2	3	1	3	2	3	2	rs146779081	byFrequency	TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:159785428G>A	uc001fud.3	+	10	1324	c.1282G>A	c.(1282-1284)GAC>AAC	p.D428N	FCRL6_uc001fuc.2_3'UTR|FCRL6_uc009wsz.1_3'UTR|FCRL6_uc009wta.2_3'UTR	NM_001004310	NP_001004310	Q6DN72	FCRL6_HUMAN	Fc receptor-like 6 precursor	428	Cytoplasmic (Potential).					integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.0597)					ACCCCTTAGCGACTGTGAGGA	0.547													10	46					0	0	0	0	A	159785428	A	A	159785428	3	1	138	1	0	0	0	0	1	0	0	0	5831	1058	37	1	1320	1	FCRL6	1	159785428	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	7960560	159785428	89465193	15	24762											
EPRS	2058	broad.mit.edu	37	chr1	220153465	220153465	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcagatataaatgcttctaTtgtagttgtatagtctcctc	11	16	7	7	0	2	1	0	0	2	1	4	1	2	1	1	0	2	5	1	0	7	9			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:220153465T>C	uc001hly.1	-	26	3943	c.3673A>G	c.(3673-3675)ATA>GTA	p.I1225V		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1225	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AATGCTTCTATTGTAGTTGTA	0.408													11	118					0	0	0	0	C	220153465	C	C	220153465	3	2	138	1	0	0	0	0	1	0	0	0	5215	1493	52	5	893	5	EPRS	1	220153465	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	60368037	220153465	29097156	16	24763											
PARP1	142	broad.mit.edu	37	chr1	226552719	226552719	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataccacgggcgcttcaggcGgggctatccgaagaccctgg	8	6	14	13	4	1	1	1	0	0	1	2	2	2	1	3	5	1	2	3	5	3	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:226552719G>A	uc001hqd.3	-	19	2813	c.2642C>T	c.(2641-2643)CCG>CTG	p.P881L		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	881	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		CGCTTCAGGCGGGGCTATCCG	0.567								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					4	90					0	0	0	0	A	226552719	A	A	226552719	3	1	138	1	0	0	0	0	1	0	0	0	11508	1116	39	1	422	1	PARP1	1	226552719	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	6399254	226552719	22697902	17	24764											
SNAP47	116841	broad.mit.edu	37	chr1	227935683	227935683	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccaagcactggttcagctcCctgcggccaagtcgaaatgt	9	8	11	13	2	1	0	1	0	0	0	3	1	2	0	3	2	3	3	3	2	3	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:227935683C>T	uc001hrf.2	+	2	795	c.381C>T	c.(379-381)TCC>TCT	p.S127S	SNAP47_uc001hqz.2_Silent_p.S82S|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_Silent_p.S127S|SNAP47_uc001hre.2_Intron|SNAP47_uc001hrg.1_Silent_p.S82S	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	127						endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						GGTTCAGCTCCCTGCGGCCAA	0.547													8	90					0	0	0	0	T	227935683	T	T	227935683	2	4	138	1	0	0	0	0	0	0	0	1	14896	610	22	4		4	SNAP47	1	227935683	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	1382964	227935683	21314938	18	24765											
GNPAT	8443	broad.mit.edu	37	chr1	231396372	231396372	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttgtgccttcaccctgagCaaagtatttaaacaaatttt	12	16	5	8	0	1	1	1	1	0	0	1	1	1	1	2	0	3	2	2	0	5	8			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:231396372C>A	uc001hup.3	+	3	587	c.381C>A	c.(379-381)AGC>AGA	p.S127R	GNPAT_uc009xfo.1_Missense_Mutation_p.S18R|GNPAT_uc009xfp.2_Missense_Mutation_p.S66R	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	127					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TCACCCTGAGCAAAGTATTTA	0.363													29	233					2.85442e-18	5.37302e-18	1	0	A	231396372	A	A	231396372	3	1	138	1	0	0	0	0	1	0	0	0	6578	709	25	4	391	4	GNPAT	1	231396372	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	3460689	231396372	17854249	19	24766											
RYR2	6262	broad.mit.edu	37	chr1	237659856	237659856	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcagtgaaggttctgctcaGtataagaaatggtactatga	13	12	11	5	0	3	3	2	2	1	1	3	3	3	3	0	2	2	4	0	2	6	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:237659856G>A	uc001hyl.1	+	20	2127	c.2007G>A	c.(2005-2007)CAG>CAA	p.Q669Q		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	669	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTTCTGCTCAGTATAAGAAAT	0.448													13	59					0	0	0	0	A	237659856	A	A	237659856	2	1	138	1	0	0	0	0	0	0	0	1	13834	1020	36	4		4	RYR2	1	237659856	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	6263484	237659856	11590765	20	24767											
AKT3	10000	broad.mit.edu	37	chr1	243708856	243708856	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttactccagagaagaaacTgtgtctcataatttcttttg	11	16	7	7	0	2	2	1	0	2	2	4	3	3	2	1	0	2	1	1	0	4	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:243708856T>C	uc001iab.1	-	11	1288	c.1207A>G	c.(1207-1209)AGT>GGT	p.S403G	AKT3_uc001hzz.1_Missense_Mutation_p.S403G	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	403	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GAGAAGAAACTGTGTCTCATA	0.328													8	54					0	0	0	0	C	243708856	C	C	243708856	3	2	138	1	0	0	0	0	1	0	0	0	481	1580	55	5	292	5	AKT3	1	243708856	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	6049000	243708856	5541765	21	24768											
OR2L3	391192	broad.mit.edu	37	chr1	248223987	248223987	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagcacacgaatgccccatgGaaaattacaatcaaacatca	18	6	6	11	1	2	0	2	0	0	0	2	3	2	1	2	1	4	1	2	1	6	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:248223987G>T	uc001idx.1	+	1	4	c.4G>T	c.(4-6)GAA>TAA	p.E2*	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ATGCCCCATGGAAAATTACAA	0.303													30	119					5.77227e-19	1.09829e-18	1	0	T	248223987	T	T	248223987	4	4	138	1	0	0	0	0	0	1	0	0	11062	1175	41	2	6	2	OR2L3	1	248223987	Nonsense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	4515131	248223987	1026634	22	24769											
OR2L3	391192	broad.mit.edu	37	chr1	248224181	248224181	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcctacttagtcagctctcCctcattgacctaaattacat	10	15	3	13	0	3	1	2	1	1	0	5	1	4	1	3	0	3	1	3	0	5	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:248224181C>G	uc001idx.1	+	1	198	c.198C>G	c.(196-198)TCC>TCG	p.S66S	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GTCAGCTCTCCCTCATTGACC	0.423													39	326					0	0	0	0	G	248224181	G	G	248224181	2	3	138	1	0	0	0	0	0	0	0	1	11062	610	22	4		4	OR2L3	1	248224181	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	194	248224181	1026440	23	24770											
MYT1L	23040	broad.mit.edu	37	chr2	1921066	1921066	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtggccggttccatcacacCcgggggttggacacttgctc	5	9	13	14	3	1	0	1	0	0	0	3	1	2	1	3	5	1	3	3	5	0	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:1921066C>A	uc002qxe.2	-	11	2356	c.1529G>T	c.(1528-1530)GGG>GTG	p.G510V	MYT1L_uc002qxd.2_Missense_Mutation_p.G508V|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	510	C2HC-type 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCCATCACACCCGGGGGTTGG	0.507													54	104					1.86277e-20	3.58303e-20	1	0	A	1921066	A	A	1921066	3	1	138	1	0	0	0	0	1	0	0	0	10160	623	22	4	2091	4	MYT1L	2	1921066	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08		1921066	241278307	24	24771											
APOB	338	broad.mit.edu	37	chr2	21239357	21239357	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtaattttcttgttctgaaTgtccagggtgagtctgtaag	9	16	11	5	0	3	2	0	2	3	0	4	2	4	2	1	1	0	3	1	1	3	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:21239357T>C	uc002red.2	-	21	3414	c.3286A>G	c.(3286-3288)ATT>GTT	p.I1096V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1096					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGTTCTGAATGTCCAGGGTG	0.478													6	46					0	0	0	0	C	21239357	C	C	21239357	3	2	138	1	0	0	0	0	1	0	0	0	785	1464	51	5	10441	5	APOB	2	21239357	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	19318291	21239357	221960016	25	24772											
ATAD2B	54454	broad.mit.edu	37	chr2	24011485	24011485	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctttgaatatacaagacCtcttcatactgtattctaaa	13	14	5	9	0	3	2	1	1	2	1	3	2	3	2	2	1	2	1	2	1	8	8			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:24011485C>A	uc002rek.3	-	20	2967	c.2673G>T	c.(2671-2673)GAG>GAT	p.E891D	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Missense_Mutation_p.E136D|ATAD2B_uc002rej.3_Missense_Mutation_p.E59D	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	891							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATACAAGACCTCTTCATACT	0.313													13	22					0.00136819	0.00218911	1	0	A	24011485	A	A	24011485	3	1	138	1	0	0	0	0	1	0	0	0	1074	680	24	4	1739	4	ATAD2B	2	24011485	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	2772128	24011485	219187888	26	24773											
DQX1	165545	broad.mit.edu	37	chr2	74745638	74745638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgctccctgctgtagaatCtgccattccttcccttagct	5	16	6	14	0	1	1	0	0	1	1	4	1	4	1	4	0	4	4	4	0	3	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:74745638C>T	uc010yrw.1	-	12	2254	c.2089G>A	c.(2089-2091)GAT>AAT	p.D697N	DQX1_uc002smc.2_Missense_Mutation_p.D258N	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	697						nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						GCTGTAGAATCTGCCATTCCT	0.532													9	51					0	0	0	0	T	74745638	T	T	74745638	3	4	138	1	0	0	0	0	1	0	0	0	4773	913	32	2	68	2	DQX1	2	74745638	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	50734153	74745638	168453735	27	24774											
GYPC	2995	broad.mit.edu	37	chr2	127451474	127451474	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtctggatggccggatggCagaatggagacctccacccc	9	7	13	12	1	1	2	0	0	1	2	2	5	2	4	5	5	0	1	5	5	1	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:127451474C>A	uc002tnq.2	+	3	297	c.141C>A	c.(139-141)GGC>GGA	p.G47G	GYPC_uc002tnr.2_Silent_p.G28G|GYPC_uc010flv.2_RNA	NM_002101	NP_002092	P04921	GLPC_HUMAN	glycophorin C isoform 1	47	Extracellular.					cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)	1	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		GGCCGGATGGCAGAATGGAGA	0.562													9	84					0.000274275	0.000446967	1	0	A	127451474	A	A	127451474	2	1	138	1	0	0	0	0	0	0	0	1	6949	697	25	4		4	GYPC	2	127451474	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	52705836	127451474	115747899	28	24775											
FMNL2	114793	broad.mit.edu	37	chr2	153504404	153504404	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcgttctgttaatggtgcCgaaataacaatgtgaacctg	11	13	10	7	2	1	1	0	1	1	0	1	2	1	1	2	1	4	2	2	1	5	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:153504404C>T	uc002tye.2	+	26	3631	c.3264C>T	c.(3262-3264)GCC>GCT	p.A1088A	FMNL2_uc010fob.2_3'UTR|FMNL2_uc002tyf.2_3'UTR	NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	Error:Variant_position_missing_in_Q96PY5_after_alignment					actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						TTAATGGTGCCGAAATAACAA	0.478													20	169					0	0	0	0	T	153504404	T	T	153504404	2	4	138	1	0	0	0	0	0	0	0	1	5984	639	23	1		1	FMNL2	2	153504404	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	26052930	153504404	89694969	29	24776											
KLHL23	151230	broad.mit.edu	37	chr2	170592711	170592711	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgatcctttaaaagagaaatGgattcctattgcaaacatga	16	12	7	6	0	0	3	0	2	0	1	2	5	2	4	2	1	2	1	2	1	5	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:170592711G>T	uc002ufh.1	+	4	1525	c.1187G>T	c.(1186-1188)TGG>TTG	p.W396L	KLHL23_uc002ufi.1_Missense_Mutation_p.W396L	NM_144711	NP_653312	Q8NBE8	KLH23_HUMAN	kelch-like 23	396	Kelch 3.										0						AAAGAGAAATGGATTCCTATT	0.408													12	104					7.03913e-09	1.22058e-08	1	0	T	170592711	T	T	170592711	3	4	138	1	0	0	0	0	1	0	0	0	8417	1357	47	4	1189	4	KLHL23	2	170592711	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	17088307	170592711	72606662	30	24777											
DNAJC10	54431	broad.mit.edu	37	chr2	183627484	183627484	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgccagaaagctgggatcAgggcctatccaactgttaaa	13	8	10	10	0	1	1	1	0	0	1	2	2	2	2	3	2	3	2	3	2	5	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:183627484A>C	uc002uow.1	+	22	2636	c.2221A>C	c.(2221-2223)AGG>CGG	p.R741R	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Silent_p.R695R|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	741	Thioredoxin 4.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			AGCTGGGATCAGGGCCTATCC	0.408													4	49					0	0	0	0	C	183627484	C	C	183627484	2	2	138	1	0	0	0	0	0	0	0	1	4651	179	7	5		5	DNAJC10	2	183627484	Silent	SNP	A	TCGA-CR-7367-01A-11D-2012-08	13034773	183627484	59571889	31	24778											
ALS2	57679	broad.mit.edu	37	chr2	202593826	202593826	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagtgtgtattctgcttcCttccttttcctgccgagatg	4	16	8	13	1	1	1	0	0	1	1	4	2	4	1	5	0	2	2	5	0	1	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:202593826C>T	uc002uyo.2	-	14	3017	c.2661G>A	c.(2659-2661)AAG>AAA	p.K887K	ALS2_uc002uyp.3_Silent_p.K887K|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	887					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						ATTCTGCTTCCTTCCTTTTCC	0.453													129	78					0	0	0	0	T	202593826	T	T	202593826	2	4	138	1	0	0	0	0	0	0	0	1	550	680	24	4		4	ALS2	2	202593826	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	18966342	202593826	40605547	32	24779											
CPS1	1373	broad.mit.edu	37	chr2	211502448	211502448	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccatgacagaagaaaccCtgaaaagggcaaaggagatt	18	5	11	7	0	0	5	0	2	0	3	1	6	1	5	2	2	1	1	2	2	5	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:211502448C>G	uc002vee.3	+	22	2842	c.2710C>G	c.(2710-2712)CTG>GTG	p.L904V	CPS1_uc010fur.2_Missense_Mutation_p.L910V|CPS1_uc010fus.2_Missense_Mutation_p.L453V	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	904					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AGAAGAAACCCTGAAAAGGGC	0.398													7	39					0	0	0	0	G	211502448	G	G	211502448	3	3	138	1	0	0	0	0	1	0	0	0	3838	680	24	4	2818	4	CPS1	2	211502448	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	8908622	211502448	31696925	33	24780											
CHRND	1144	broad.mit.edu	37	chr2	233398936	233398936	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcccctcgtctgtaggcCggcccccagcaagctctgag	5	7	12	17	2	2	1	0	1	2	0	3	1	2	1	5	3	2	3	5	3	2	1	rs140455307		TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:233398936C>T	uc002vsw.2	+	11	1259	c.1255C>T	c.(1255-1257)CGG>TGG	p.R419W	CHRND_uc010zmg.1_Missense_Mutation_p.R404W|CHRND_uc010fyc.2_Missense_Mutation_p.R292W|CHRND_uc010zmh.1_Missense_Mutation_p.R225W	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	419	Cytoplasmic (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GTCTGTAGGCCGGCCCCCAGC	0.607													12	71					0	0	0	0	T	233398936	T	T	233398936	3	4	138	1	0	0	0	0	1	0	0	0	3409	643	23	1	1297	1	CHRND	2	233398936	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	21896488	233398936	9800437	34	24781											
GIGYF2	26058	broad.mit.edu	37	chr2	233680442	233680442	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agctagagaaggccaaagctGcaaaggtctgaaactcattc	15	7	10	9	0	2	2	1	1	1	1	3	3	2	2	1	2	4	3	1	2	5	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:233680442G>T	uc002vti.3	+	21	2540	c.2203G>T	c.(2203-2205)GCA>TCA	p.A735S	GIGYF2_uc010zmj.1_Missense_Mutation_p.A735S|GIGYF2_uc002vtg.2_Missense_Mutation_p.A729S|GIGYF2_uc002vtj.3_Missense_Mutation_p.A756S|GIGYF2_uc002vtk.3_Missense_Mutation_p.A735S|GIGYF2_uc002vth.3_Missense_Mutation_p.A729S|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.A566S|GIGYF2_uc002vtq.3_Missense_Mutation_p.A68S	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	735	Gln-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GGCCAAAGCTGCAAAGGTCTG	0.478													3	29					0.004672	0.00740786	1	0	T	233680442	T	T	233680442	3	4	138	1	0	0	0	0	1	0	0	0	6415	1319	46	4	2339	4	GIGYF2	2	233680442	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	281506	233680442	9518931	35	24782											
HDAC4	9759	broad.mit.edu	37	chr2	240085518	240085518	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgtaccagtagcgagggtCgctggaaatgcagtggttca	9	8	14	10	3	1	0	1	0	0	0	2	2	1	1	2	3	3	5	2	3	3	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:240085518C>T	uc002vyk.3	-	6	1384	c.592G>A	c.(592-594)GAC>AAC	p.D198N	HDAC4_uc010fyz.1_Missense_Mutation_p.D193N|HDAC4_uc010zoa.1_Missense_Mutation_p.D193N|HDAC4_uc010fza.2_Missense_Mutation_p.D198N|HDAC4_uc010fyy.2_Missense_Mutation_p.D150N|HDAC4_uc010znz.1_Missense_Mutation_p.D81N	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	198	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		TAGCGAGGGTCGCTGGAAATG	0.562													22	78					0	0	0	0	T	240085518	T	T	240085518	3	4	138	1	0	0	0	0	1	0	0	0	7048	884	31	1	2750	1	HDAC4	2	240085518	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	6405076	240085518	3113855	36	24783											
RAF1	5894	broad.mit.edu	37	chr3	12653459	12653459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagctcttaccctttgtgttCgtggagaagtctgaacactg	8	13	11	9	1	2	2	0	1	2	1	3	4	2	2	1	1	3	2	1	1	3	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:12653459C>T	uc003bxf.3	-	3	725	c.310G>A	c.(310-312)GAA>AAA	p.E104K	RAF1_uc011aut.1_5'Flank|RAF1_uc011auu.1_Intron	NM_002880	NP_002871	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog	104	RBD.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)	CCTTTGTGTTCGTGGAGAAGT	0.428			T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				49	87					0	0	0	0	T	12653459	T	T	12653459	3	4	138	1	0	0	0	0	1	0	0	0	13067	893	31	1	1696	1	RAF1	3	12653459	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08		12653459	185368971	37	24784											
C3orf75	54859	broad.mit.edu	37	chr3	47552662	47552662	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagatagaaggagagaaagtGgtgtacaaggaaactcccat	17	6	13	5	0	0	3	0	0	0	3	1	7	1	5	1	3	2	1	1	3	6	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:47552662G>T	uc003crk.2	-	2	228	c.109C>A	c.(109-111)CAC>AAC	p.H37N	C3orf75_uc003crj.2_5'UTR|C3orf75_uc011bba.1_Silent_p.T11T|C3orf75_uc003crl.1_Missense_Mutation_p.H37N	NM_001031703	NP_001026873	Q0PNE2	CC075_HUMAN	transmembrane protein 103	37											0						GAGAGAAAGTGGTGTACAAGG	0.403													8	51					9.70103e-10	1.69889e-09	1	0	T	47552662	T	T	47552662	3	4	138	1	0	0	0	0	1	0	0	0	2255	1348	47	4	715	4	C3orf75	3	47552662	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	34899203	47552662	150469768	38	24785											
ATRIP	84126	broad.mit.edu	37	chr3	48491541	48491541	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aagataatttcgaattagagGtacttcaggcacaatacaaa	18	10	7	6	1	1	2	1	0	0	2	2	3	1	2	0	2	2	2	0	2	8	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:48491541G>T	uc003ctf.1	+	2	378	c.346G>T	c.(346-348)GTA>TTA	p.V116L	ATRIP_uc011bbj.1_5'UTR|ATRIP_uc003ctg.1_Missense_Mutation_p.V116L	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	116	Potential.				DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CGAATTAGAGGTACTTCAGGC	0.333								Other_conserved_DNA_damage_response_genes					31	53					1.88708e-17	3.53326e-17	1	0	T	48491541	T	T	48491541	3	4	138	1	0	0	0	0	1	0	0	0	1207	1261	44	4	352	4	ATRIP	3	48491541	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	938879	48491541	149530889	39	24786											
RNF123	63891	broad.mit.edu	37	chr3	49744294	49744294	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagctggaccacctgagccGccgtcttgcctgggtccatg	7	8	12	14	2	1	1	0	1	1	0	2	2	2	2	6	2	3	1	6	2	1	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:49744294G>A	uc003cxh.2	+	26	2545	c.2459G>A	c.(2458-2460)CGC>CAC	p.R820H	RNF123_uc010hky.1_Missense_Mutation_p.R482H|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	820						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CACCTGAGCCGCCGTCTTGCC	0.567													12	45					0	0	0	0	A	49744294	A	A	49744294	3	1	138	1	0	0	0	0	1	0	0	0	13498	1087	38	1	2557	1	RNF123	3	49744294	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	1252753	49744294	148278136	40	24787											
CBLB	868	broad.mit.edu	37	chr3	105421037	105421037	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattgacatttgaactcgcTgtgattccaggttttggaga	9	14	10	8	1	0	4	0	3	0	1	2	5	1	4	2	2	1	2	2	2	1	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:105421037T>A	uc003dwc.2	-	12	2182	c.1860A>T	c.(1858-1860)ACA>ACT	p.T620T	CBLB_uc011bhi.1_Silent_p.T642T|CBLB_uc003dwd.1_Silent_p.T620T|CBLB_uc003dwe.1_Silent_p.T620T	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	620	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TTGAACTCGCTGTGATTCCAG	0.517			Mis S		AML								20	100					0	0	0	0	A	105421037	A	A	105421037	2	1	138	1	0	0	0	0	0	0	0	1	2713	1567	55	5		5	CBLB	3	105421037	Silent	SNP	T	TCGA-CR-7367-01A-11D-2012-08	55676743	105421037	92601393	41	24788											
CCDC54	84692	broad.mit.edu	37	chr3	107096565	107096565	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcggcaccaagattcaactgGatatcccactgtgacatctg	11	10	8	12	1	2	2	1	1	1	1	4	3	3	3	2	2	1	1	2	2	3	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:107096565G>C	uc003dwi.1	+	1	378	c.131G>C	c.(130-132)GGA>GCA	p.G44A		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	44											0						GATTCAACTGGATATCCCACT	0.398													16	94					0	0	0	0	C	107096565	C	C	107096565	3	2	138	1	0	0	0	0	1	0	0	0	2837	1174	41	2	133	2	CCDC54	3	107096565	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	1675528	107096565	90925865	42	24789											
LRRC58	116064	broad.mit.edu	37	chr3	120053967	120053967	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagttattgtgaagacttaGggaacgaagtgaatgtaacc	15	10	11	5	1	0	3	0	2	0	1	0	5	0	4	1	1	2	2	1	1	8	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:120053967G>A	uc003edr.2	-	3	745	c.649C>T	c.(649-651)CTA>TTA	p.L217L		NM_001099678	NP_001093148	Q96CX6	LRC58_HUMAN	leucine rich repeat containing 58	217	LRR 8.										0				GBM - Glioblastoma multiforme(114;0.147)		TGAAGACTTAGGGAACGAAGT	0.348													4	53					0	0	0	0	A	120053967	A	A	120053967	2	1	138	1	0	0	0	0	0	0	0	1	9064	991	35	4		4	LRRC58	3	120053967	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	12957402	120053967	77968463	43	24790											
UROC1	131669	broad.mit.edu	37	chr3	126220060	126220060	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caactcccaacccccactcaCcaaagagccaccacgttgcc	12	4	4	21	1	1	1	1	0	0	1	2	1	2	1	7	0	4	1	7	0	3	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:126220060C>T	uc003eiz.1	-	10	997	c.965_splice	c.e10+1	p.W322_splice	UROC1_uc010hsi.1_Splice_Site_p.W382_splice	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1						histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		CCCCCACTCACCAAAGAGCCA	0.562													29	282					0	0	0	0	T	126220060	T	T	126220060	5	4	138	1	0	0	0	0	0	0	1	0	17096	521	18	4	1108	4	UROC1	3	126220060	Splice_Site	SNP	C	TCGA-CR-7367-01A-11D-2012-08	6166093	126220060	71802370	44	24791											
ASTE1	28990	broad.mit.edu	37	chr3	130742943	130742943	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattaatcctttccacttcaCtgaaagctagaggctgagga	12	12	8	9	0	1	3	1	2	0	1	3	4	3	4	2	2	1	2	2	2	4	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:130742943C>A	uc003env.1	-	3	1650	c.1208G>T	c.(1207-1209)AGT>ATT	p.S403I	NEK11_uc003enx.2_5'Flank|NEK11_uc003eny.2_5'Flank|NEK11_uc003eoa.2_5'Flank|NEK11_uc003enz.2_5'Flank|NEK11_uc010htn.2_5'Flank|NEK11_uc011blk.1_5'Flank|NEK11_uc011bll.1_5'Flank|NEK11_uc003enw.1_5'Flank|NEK11_uc011blm.1_5'Flank|ASTE1_uc010htm.1_Missense_Mutation_p.S403I|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	403					DNA repair		nuclease activity				0						TTCCACTTCACTGAAAGCTAG	0.428													48	106					6.7651e-33	1.31564e-32	1	0	A	130742943	A	A	130742943	3	1	138	1	0	0	0	0	1	0	0	0	1064	565	20	4	847	4	ASTE1	3	130742943	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	4522883	130742943	67279487	45	24792											
TMEM22	80723	broad.mit.edu	37	chr3	136574278	136574278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttatctcattgctatatgtGtctgttctactgcagcattc	7	18	7	9	0	3	0	1	0	3	0	5	0	3	0	0	0	4	5	0	0	4	7			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:136574278G>A	uc003erf.3	+	2	1190	c.976G>A	c.(976-978)GTC>ATC	p.V326I	TMEM22_uc003erg.3_Missense_Mutation_p.V326I|TMEM22_uc010hub.2_Missense_Mutation_p.V326I	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	326	DUF6 2.|Helical; (Potential).					Golgi apparatus|integral to membrane				ovary(1)	1						TGCTATATGTGTCTGTTCTAC	0.393													75	189					0	0	0	0	A	136574278	A	A	136574278	3	1	138	1	0	0	0	0	1	0	0	0	16209	1377	48	4	978	4	TMEM22	3	136574278	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	5831335	136574278	61448152	46	24793											
TM4SF4	7104	broad.mit.edu	37	chr3	149216509	149216509	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtcccctatatcaccaacagGgattatctcaatgatgaggc	12	10	8	11	0	2	2	2	2	1	0	4	3	3	3	3	2	1	0	3	2	5	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:149216509G>C	uc003exd.1	+	4	633	c.402G>C	c.(400-402)GGG>GGC	p.G134G		NM_004617	NP_004608	P48230	T4S4_HUMAN	transmembrane 4 superfamily member 4	134	Extracellular (Potential).					integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TCACCAACAGGGATTATCTCA	0.448													4	35					0	0	0	0	C	149216509	C	C	149216509	2	2	138	1	0	0	0	0	0	0	0	1	16036	1246	43	4		4	TM4SF4	3	149216509	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	12642231	149216509	48805921	47	24794											
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	17	7	10	7	0	1	2	1	2	0	0	1	4	1	3	0	3	3	2	0	3	5	0	rs121913279		TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	43					0	0	0	0	G	178952085	G	G	178952085	3	3	138	1	0	0	0	0	1	0	0	0	11968	217	8	5	3218	5	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	29735576	178952085	19070345	48	24795											
FAM131A	131408	broad.mit.edu	37	chr3	184059698	184059698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttcctgtgagtacatgctggGgtctcccctttcttcccttg	3	16	9	13	0	2	1	0	1	2	0	5	1	4	1	4	2	2	2	4	2	1	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:184059698G>A	uc003fog.2	+	1	1441	c.77G>A	c.(76-78)GGG>GAG	p.G26E	FAM131A_uc003fob.1_Intron|FAM131A_uc003foc.2_Intron|FAM131A_uc003foe.2_Intron	NM_144635	NP_653236	Q6UXB0	F131A_HUMAN	hypothetical protein LOC131408 precursor	26						extracellular region				breast(1)	1	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TACATGCTGGGGTCTCCCCTT	0.547													67	127					0	0	0	0	A	184059698	A	A	184059698	3	1	138	1	0	0	0	0	1	0	0	0	5467	1247	43	4		4	FAM131A	3	184059698	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	5107613	184059698	13962732	49	24796											
C3orf59	151963	broad.mit.edu	37	chr3	192516720	192516720	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgatggctttgcaggcctGataggcctgcatgaggctgc	7	10	15	9	0	0	3	0	3	0	0	0	4	0	3	2	4	3	4	2	4	1	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:192516720G>C	uc011bsp.1	-	2	1252	c.931C>G	c.(931-933)CAG>GAG	p.Q311E		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	311											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGCAGGCCTGATAGGCCTGC	0.557													9	40					0	0	0	0	C	192516720	C	C	192516720	3	2	138	1	0	0	0	0	1	0	0	0	2247	1299	45	2	548	2	C3orf59	3	192516720	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	8457022	192516720	5505710	50	24797											
WHSC1	7468	broad.mit.edu	37	chr4	1955057	1955057	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taactttttgttagggattcActcatgtttcgtgtgtaaag	9	18	9	5	1	2	0	2	0	0	0	3	1	2	1	0	1	1	3	0	1	4	7			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:1955057A>T	uc003gdz.3	+	12	2320	c.2144A>T	c.(2143-2145)CAC>CTC	p.H715L	WHSC1_uc003geb.3_Missense_Mutation_p.H715L|WHSC1_uc003gec.3_Missense_Mutation_p.H715L|WHSC1_uc003ged.3_Missense_Mutation_p.H715L|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_5'UTR|WHSC1_uc011bvh.1_5'UTR|WHSC1_uc010icf.2_Missense_Mutation_p.H63L	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	715	PHD-type 2.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TTAGGGATTCACTCATGTTTC	0.403			T	IGH@	MM								10	87					0	0	0	0	T	1955057	T	T	1955057	3	4	138	1	0	0	0	0	1	0	0	0	17430	159	6	5	2262	5	WHSC1	4	1955057	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08		1955057	189199219	51	24798											
TBC1D14	57533	broad.mit.edu	37	chr4	7026838	7026848	+	Frame_Shift_Del	DEL	TCCTGAAGCTG	-	-																															gttccgcacggccctgggcaTcctgaagctgttcgaggaca																										TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:7026838_7026848delTCCTGAAGCTG	uc011bwg.1	+	13	1944_1954	c.1865_1875delTCCTGAAGCTG	c.(1864-1875)ATCCTGAAGCTGfs	p.I622fs	TBC1D14_uc003gjs.3_Frame_Shift_Del_p.I622fs|TBC1D14_uc010idh.2_Frame_Shift_Del_p.I342fs|TBC1D14_uc011bwh.1_Frame_Shift_Del_p.I269fs|TBC1D14_uc003gju.3_Frame_Shift_Del_p.I113fs	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	622_625						intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						GCCCTGGGCATCCTGAAGCTGTTCGAGGACA	0.588													---	---	---								-	7026848	-	-	7026838	7	5	138	1	0	1	0	1	0	0	0	0	15669	1435	50	0	1918	0	TBC1D14	4	7026838	Frame_Shift_Del	DEL	TCCTGAAGCTG	TCGA-CR-7367-01A-11D-2012-08	5071781	7026838	184127438	52	24799											
SCFD2	152579	broad.mit.edu	37	chr4	53751945	53751945	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcaacgatgccacaagaTctttgaccattttcacttca	11	13	5	12	1	4	2	3	1	1	1	4	3	4	2	2	0	2	1	2	0	2	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:53751945T>C	uc003gzu.2	-	8	2065	c.1931A>G	c.(1930-1932)GAT>GGT	p.D644G	SCFD2_uc010igm.2_Missense_Mutation_p.D599G	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	644					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TGCCACAAGATCTTTGACCAT	0.532													10	87					0	0	0	0	C	53751945	C	C	53751945	3	2	138	1	0	0	0	0	1	0	0	0	13955	1435	50	5	131	5	SCFD2	4	53751945	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	46725107	53751945	137402331	53	24800											
UGT2B4	7363	broad.mit.edu	37	chr4	70359477	70359477	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaacatttggtaagagtggGtgaggaaattgaaaatccca	15	10	11	5	0	1	3	1	2	0	1	2	4	2	4	1	3	1	1	1	3	5	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:70359477G>T	uc003hek.3	-	2	851	c.804C>A	c.(802-804)CAC>CAA	p.H268Q	UGT2B4_uc011cap.1_Missense_Mutation_p.H132Q|UGT2B4_uc003hel.3_Missense_Mutation_p.H268Q	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	268					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						GTAAGAGTGGGTGAGGAAATT	0.423													40	88					4.32679e-17	8.05836e-17	1	0	T	70359477	T	T	70359477	3	4	138	1	0	0	0	0	1	0	0	0	17029	1252	44	4	802	4	UGT2B4	4	70359477	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	16607532	70359477	120794799	54	24801											
SLC4A4	8671	broad.mit.edu	37	chr4	72423471	72423471	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgatgcctctgaagcatCagcctgacttcatctacctg	8	13	7	13	0	5	3	2	3	3	0	5	3	5	3	3	0	4	1	3	0	2	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:72423471C>T	uc003hfy.2	+	22	2923	c.2806C>T	c.(2806-2808)CAG>TAG	p.Q936*	SLC4A4_uc010iic.2_Nonsense_Mutation_p.Q936*|SLC4A4_uc010iib.2_Nonsense_Mutation_p.Q852*|SLC4A4_uc003hfz.2_Nonsense_Mutation_p.Q936*|SLC4A4_uc003hgc.3_Nonsense_Mutation_p.Q892*|SLC4A4_uc010iid.2_Nonsense_Mutation_p.Q140*	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	936	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TCTGAAGCATCAGCCTGACTT	0.507													15	41					0	0	0	0	T	72423471	T	T	72423471	4	4	138	1	0	0	0	0	0	1	0	0	14720	827	29	2	3009	2	SLC4A4	4	72423471	Nonsense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	2063994	72423471	118730805	55	24802											
NPFFR2	10886	broad.mit.edu	37	chr4	73012719	73012719	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtgtgtggtctaccctttTaaaccaaagctcactatcaa	12	12	6	11	0	3	0	2	0	1	0	3	0	3	0	2	1	3	1	2	1	6	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:73012719T>G	uc003hgg.2	+	4	857	c.759T>G	c.(757-759)TTT>TTG	p.F253L	NPFFR2_uc010iig.1_Missense_Mutation_p.F35L|NPFFR2_uc003hgi.2_Missense_Mutation_p.F154L|NPFFR2_uc003hgh.2_Missense_Mutation_p.F151L|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	253	Cytoplasmic (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TCTACCCTTTTAAACCAAAGC	0.388													13	169					0	0	0	0	G	73012719	G	G	73012719	3	3	138	1	0	0	0	0	1	0	0	0	10632	1751	61	5	779	5	NPFFR2	4	73012719	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	589248	73012719	118141557	56	24803											
FAM175A	84142	broad.mit.edu	37	chr4	84384670	84384670	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctgaatctgtgctcctCtccttttctcaatttctcgt	4	18	5	14	1	4	1	1	1	4	0	8	1	5	1	3	0	2	1	3	0	2	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:84384670C>A	uc003hou.2	-	8	838	c.773G>T	c.(772-774)AGA>ATA	p.R258I	MRPS18C_uc011ccu.1_Intron|FAM175A_uc003hot.2_Missense_Mutation_p.R86I|FAM175A_uc003hov.2_Missense_Mutation_p.R149I	NM_139076	NP_620775	Q6UWZ7	F175A_HUMAN	coiled-coil domain containing 98	258	Potential.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1						CTGTGCTCCTCTCCTTTTCTC	0.284													10	66					7.48243e-07	1.27237e-06	1	0	A	84384670	A	A	84384670	3	1	138	1	0	0	0	0	1	0	0	0	5525	913	32	2	464	2	FAM175A	4	84384670	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	11371951	84384670	106769606	57	24804											
MAPK10	5602	broad.mit.edu	37	chr4	86988972	86988972	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gctgggaagagggaatctggGaagagtttggggaaggtgag	11	7	21	2	0	1	3	0	1	1	2	1	7	1	7	0	6	0	2	0	6	4	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:86988972G>C	uc003hpq.2	-	9	1006	c.939C>G	c.(937-939)TTC>TTG	p.F313L	MAPK10_uc010ikg.2_Missense_Mutation_p.F275L|MAPK10_uc003hpr.2_Missense_Mutation_p.F275L|MAPK10_uc003hps.2_Missense_Mutation_p.F313L|MAPK10_uc003hpt.2_Missense_Mutation_p.F313L|MAPK10_uc003hpu.2_Missense_Mutation_p.F313L|MAPK10_uc003hpv.2_Missense_Mutation_p.F168L|MAPK10_uc003hpn.2_Missense_Mutation_p.F61L|MAPK10_uc003hpo.2_Missense_Mutation_p.F168L|MAPK10_uc011ccw.1_Missense_Mutation_p.F199L|MAPK10_uc003hpp.2_Missense_Mutation_p.F168L	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	313	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		GGGAATCTGGGAAGAGTTTGG	0.488													10	27					0	0	0	0	C	86988972	C	C	86988972	3	2	138	1	0	0	0	0	1	0	0	0	9325	1165	41	2	480	2	MAPK10	4	86988972	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	2604302	86988972	104165304	58	24805											
HERC6	55008	broad.mit.edu	37	chr4	89318075	89318075	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catggaccaagtgacacaagCaagccaactcatccggaggc	14	4	10	13	1	1	1	1	1	0	0	2	3	2	3	3	3	3	1	3	3	4	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:89318075C>A	uc011cdi.1	+	7	1143	c.960C>A	c.(958-960)AGC>AGA	p.S320R	HERC6_uc003hrp.1_Intron|HERC6_uc011cdj.1_Missense_Mutation_p.S320R|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_Intron	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	320					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		GTGACACAAGCAAGCCAACTC	0.453													7	141					0.00307968	0.00490519	1	0	A	89318075	A	A	89318075	3	1	138	1	0	0	0	0	1	0	0	0	7101	709	25	4	783	4	HERC6	4	89318075	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	2329103	89318075	101836201	59	24806											
ADH4	127	broad.mit.edu	37	chr4	100062731	100062731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctggcccaatactttccaCaatacctgcagcctcatggc	9	10	6	16	0	1	0	1	0	0	0	3	0	3	0	5	2	4	1	5	2	4	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:100062731C>T	uc003hun.2	-	3	299	c.223G>A	c.(223-225)GTG>ATG	p.V75M	uc003hum.1_Intron|ADH4_uc011ced.1_Missense_Mutation_p.V94M	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	75					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	ATACTTTCCACAATACCTGCA	0.403													5	24					0	0	0	0	T	100062731	T	T	100062731	3	4	138	1	0	0	0	0	1	0	0	0	310	478	17	4	947	4	ADH4	4	100062731	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	10744656	100062731	91091545	60	24807											
ADH1A	124	broad.mit.edu	37	chr4	100205642	100205642	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagaggcgaggctgcatcaaTtttggctactgcattttcat	9	14	10	8	1	2	1	2	0	0	1	2	2	2	1	0	3	3	4	0	3	3	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:100205642T>C	uc003hur.1	-	5	552	c.481A>G	c.(481-483)ATT>GTT	p.I161V	uc003hum.1_Intron|ADH1A_uc011ceg.1_Missense_Mutation_p.I161V|ADH1A_uc010ilf.1_5'UTR	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit	161					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	GCTGCATCAATTTTGGCTACT	0.493													9	43					0	0	0	0	C	100205642	C	C	100205642	3	2	138	1	0	0	0	0	1	0	0	0	307	1493	52	5	666	5	ADH1A	4	100205642	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	142911	100205642	90948634	61	24808											
LEF1	51176	broad.mit.edu	37	chr4	109088757	109088757	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tttcagactcgttcaccaagGaagacttgatgtcagctaaa	13	11	8	9	1	3	3	3	1	0	2	4	4	3	4	1	1	1	2	1	1	4	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:109088757G>A	uc003hyt.1	-	1	822	c.167C>T	c.(166-168)TCC>TTC	p.S56F	LEF1_uc011cfj.1_5'Flank|LEF1_uc011cfk.1_5'Flank|LEF1_uc003hyu.1_Missense_Mutation_p.S56F|LEF1_uc003hyv.1_Missense_Mutation_p.S56F|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	56	CTNNB1-binding (By similarity).				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		GTTCACCAAGGAAGACTTGAT	0.577													19	89					0	0	0	0	A	109088757	A	A	109088757	3	1	138	1	0	0	0	0	1	0	0	0	8754	1174	41	2	1173	2	LEF1	4	109088757	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	8883115	109088757	82065519	62	24809											
COL25A1	84570	broad.mit.edu	37	chr4	110222987	110222987	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttggcggattcgagagcggcGatcctcgcctggaggtcgtt	5	10	16	10	6	0	1	0	0	0	1	4	5	1	3	2	5	1	1	2	5	0	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:110222987G>A	uc003hze.1	-	2	720	c.189C>T	c.(187-189)ATC>ATT	p.I63I	COL25A1_uc003hzg.2_Silent_p.I63I|COL25A1_uc003hzh.1_Silent_p.I63I	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	63	Extracellular (Potential).					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CGAGAGCGGCGATCCTCGCCT	0.607													11	74					0	0	0	0	A	110222987	A	A	110222987	2	1	138	1	0	0	0	0	0	0	0	1	3699	1048	37	1		1	COL25A1	4	110222987	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	1134230	110222987	80931289	63	24810											
DCHS2	54798	broad.mit.edu	37	chr4	155158157	155158157	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agattataggatttgactgtGaattcaggggcataattgtt	12	15	11	3	0	1	3	1	2	0	1	1	4	1	4	0	3	0	2	0	3	4	7			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:155158157G>A	uc003inw.2	-	25	6282	c.6282C>T	c.(6280-6282)TTC>TTT	p.F2094F		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2094	Cadherin 18.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATTTGACTGTGAATTCAGGGG	0.418													17	90					0	0	0	0	A	155158157	A	A	155158157	2	1	138	1	0	0	0	0	0	0	0	1	4305	1281	45	2		2	DCHS2	4	155158157	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	44935170	155158157	35996119	64	24811											
SEMA5A	9037	broad.mit.edu	37	chr5	9066574	9066574	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccgtcgctagaacagtacCgcatttcgattctctgtctt	7	14	8	12	4	2	1	0	0	2	1	5	2	2	1	2	0	3	3	2	0	3	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:9066574C>T	uc003jek.2	-	17	2970	c.2258G>A	c.(2257-2259)CGG>CAG	p.R753Q		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	753	TSP type-1 4.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						AGAACAGTACCGCATTTCGAT	0.537													29	128					0	0	0	0	T	9066574	T	T	9066574	3	4	138	1	0	0	0	0	1	0	0	0	14102	652	23	1	994	1	SEMA5A	5	9066574	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08		9066574	171848686	65	24812											
CDH6	1004	broad.mit.edu	37	chr5	31323025	31323025	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacattgtcagttacaacgaCgaaggtggtggagaggagga	14	7	15	5	2	1	1	1	0	0	1	1	6	1	3	0	5	3	1	0	5	4	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:31323025C>T	uc003jhe.1	+	12	2309	c.1983C>T	c.(1981-1983)GAC>GAT	p.D661D		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	661	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						GTTACAACGACGAAGGTGGTG	0.493													12	66					0	0	0	0	T	31323025	T	T	31323025	2	4	138	1	0	0	0	0	0	0	0	1	3129	535	19	1		1	CDH6	5	31323025	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	22256451	31323025	149592235	66	24813											
OSMR	9180	broad.mit.edu	37	chr5	38933399	38933399	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtttggagacaaggacagTctcccaacaaacccagtaga	15	7	9	10	0	1	2	0	0	1	2	2	4	1	3	2	2	2	2	2	2	4	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:38933399T>C	uc003jln.1	+	18	3160	c.2793T>C	c.(2791-2793)AGT>AGC	p.S931S	OSMR_uc011cpj.1_Silent_p.S135S	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	931	Cytoplasmic (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					ACAAGGACAGTCTCCCAACAA	0.483													19	171					0	0	0	0	C	38933399	C	C	38933399	2	2	138	1	0	0	0	0	0	0	0	1	11346	1664	58	5		5	OSMR	5	38933399	Silent	SNP	T	TCGA-CR-7367-01A-11D-2012-08	7610374	38933399	141981861	67	24814											
ANKRD55	79722	broad.mit.edu	37	chr5	55407004	55407004	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggagacctcttggtgaccaGgccggacactgagcaatctg	9	7	13	12	2	2	3	0	2	2	1	2	5	2	4	3	4	1	1	3	4	1	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:55407004G>T	uc003jqu.2	-	10	1723	c.1571C>A	c.(1570-1572)CCT>CAT	p.P524H	ANKRD55_uc003jqt.2_Missense_Mutation_p.P236H	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	523										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				TTGGTGACCAGGCCGGACACT	0.463													22	168					2.21704e-12	4.00203e-12	1	0	T	55407004	T	T	55407004	3	4	138	1	0	0	0	0	1	0	0	0	681	1000	35	4	285	4	ANKRD55	5	55407004	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	16473605	55407004	125508256	68	24815											
MCCC2	64087	broad.mit.edu	37	chr5	70898414	70898414	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actgtgaaaaaacaattacgGgcccaagaaattgccatgca	17	7	8	9	1	0	2	0	1	0	1	0	2	0	2	2	1	4	1	2	1	7	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:70898414G>A	uc003kbs.3	+	5	603	c.465G>A	c.(463-465)CGG>CGA	p.R155R	MCCC2_uc010iyv.1_Silent_p.R155R|MCCC2_uc003kbt.3_RNA|MCCC2_uc003kbu.1_Silent_p.R24R	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	155	Carboxyltransferase.		R -> Q (in MCC2 deficiency; mild form).		leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	AACAATTACGGGCCCAAGAAA	0.418													5	43					0	0	0	0	A	70898414	A	A	70898414	2	1	138	1	0	0	0	0	0	0	0	1	9428	1219	43	4		4	MCCC2	5	70898414	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	15491410	70898414	110016846	69	24816											
MTX3	345778	broad.mit.edu	37	chr5	79282892	79282892	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accgtactttgtaaagaggtGcaagaaaaccaaaaacatag	19	7	8	7	1	0	2	0	0	0	2	0	2	0	2	2	1	4	3	2	1	9	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:79282892G>T	uc010jag.2	-	7	647	c.620C>A	c.(619-621)GCA>GAA	p.A207E	MTX3_uc010jah.2_Missense_Mutation_p.A207E|MTX3_uc003kge.3_Missense_Mutation_p.A146E|MTX3_uc003kgf.1_RNA	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	207					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		GTAAAGAGGTGCAAGAAAACC	0.348													17	44					2.35188e-11	4.20235e-11	1	0	T	79282892	T	T	79282892	3	4	138	1	0	0	0	0	1	0	0	0	10022	1319	46	4	330	4	MTX3	5	79282892	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	8384478	79282892	101632368	70	24817											
WNT8A	7478	broad.mit.edu	37	chr5	137426351	137426351	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaggccaagtatgaccaggcGctgaaaattgaaatggataa	17	7	11	6	1	0	3	0	3	0	0	0	4	0	4	2	3	0	2	2	3	7	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:137426351G>A	uc003lcd.1	+	6	650	c.645G>A	c.(643-645)GCG>GCA	p.A215A	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_Silent_p.A233A|WNT8A_uc011cyk.1_Silent_p.A233A	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	215					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ATGACCAGGCGCTGAAAATTG	0.587													8	41					0	0	0	0	A	137426351	A	A	137426351	2	1	138	1	0	0	0	0	0	0	0	1	17464	1074	38	1		1	WNT8A	5	137426351	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	58143459	137426351	43488909	71	24818											
PCDHA1	56147	broad.mit.edu	37	chr5	140165973	140165973	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggggagcggccagctccactActcgatcccggaggaagcca	9	4	14	14	3	0	0	0	0	0	0	3	4	2	3	4	5	4	1	4	5	2	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:140165973A>C	uc003lhb.2	+	1	98	c.98A>C	c.(97-99)TAC>TCC	p.Y33S	PCDHA1_uc003lha.2_Missense_Mutation_p.Y33S|PCDHA1_uc003lgz.2_Missense_Mutation_p.Y33S	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	33	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCTCCACTACTCGATCCCG	0.652													12	80					0	0	0	0	C	140165973	C	C	140165973	3	2	138	1	0	0	0	0	1	0	0	0	11573	391	14	5	100	5	PCDHA1	5	140165973	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	2739622	140165973	40749287	72	24819											
PCDHA6	56142	broad.mit.edu	37	chr5	140209865	140209865	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctcggcgccacccaccgaggGcgcgtgcacggcggacaagc	7	2	15	17	7	0	0	0	0	0	0	1	2	0	1	3	4	2	1	3	4	1	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:140209865G>A	uc003lho.2	+	1	2216	c.2189G>A	c.(2188-2190)GGC>GAC	p.G730D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.G730D	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	730	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCACCGAGGGCGCGTGCACG	0.682													31	55					0	0	0	0	A	140209865	A	A	140209865	3	1	138	1	0	0	0	0	1	0	0	0	11582	1203	42	4	2191	4	PCDHA6	5	140209865	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	43892	140209865	40705395	73	24820											
PCDHAC2	56134	broad.mit.edu	37	chr5	140346785	140346785	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attggacatcaacgacaactCaccgcgtttcccgcggccca	10	7	8	16	5	2	0	2	0	0	0	3	2	3	1	3	2	2	1	3	2	2	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:140346785C>G	uc003lii.2	+	1	674	c.434C>G	c.(433-435)TCA>TGA	p.S145*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Nonsense_Mutation_p.S145*	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	145	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGACAACTCACCGCGTTTC	0.632													8	29					0	0	0	0	G	140346785	G	G	140346785	4	3	138	1	0	0	0	0	0	1	0	0	11587	838	29	2	436	2	PCDHAC2	5	140346785	Nonsense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	136920	140346785	40568475	74	24821											
PCDHB10	56126	broad.mit.edu	37	chr5	140572211	140572211	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtgtccttggcaggttctgGgtttggacgttattcggtga	5	15	15	6	2	1	1	0	1	1	0	3	2	2	2	1	5	0	4	1	5	1	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:140572211G>T	uc003lix.2	+	1	260	c.86G>T	c.(85-87)GGG>GTG	p.G29V		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	29	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGGTTCTGGGTTTGGACGT	0.502													22	112					1.1804e-14	2.16406e-14	1	0	T	140572211	T	T	140572211	3	4	138	1	0	0	0	0	1	0	0	0	11589	1232	43	4	88	4	PCDHB10	5	140572211	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	225426	140572211	40343049	75	24822											
ARSI	340075	broad.mit.edu	37	chr5	149676799	149676799	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatccgttgggacattagcCtggtgttgagtttacggaaa	10	12	13	6	2	0	2	0	1	0	1	1	4	1	4	2	3	2	3	2	3	3	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:149676799C>T	uc003lrv.2	-	2	2277	c.1688G>A	c.(1687-1689)AGG>AAG	p.R563K		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	563						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGACATTAGCCTGGTGTTGAG	0.532													16	95					0	0	0	0	T	149676799	T	T	149676799	3	4	138	1	0	0	0	0	1	0	0	0	996	681	24	4	25	4	ARSI	5	149676799	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	9104588	149676799	31238461	76	24823											
HIST1H4F	8361	broad.mit.edu	37	chr6	26240858	26240858	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcctggagaatgtgatacggGacgccgtaacctacacggag	11	7	13	10	4	0	2	0	1	0	1	1	5	1	4	3	3	3	1	3	3	4	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:26240858G>T	uc003nhe.1	+	1	205	c.205G>T	c.(205-207)GAC>TAC	p.D69Y		NM_003540	NP_003531	P62805	H4_HUMAN	histone cluster 1, H4f	69					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TGTGATACGGGACGCCGTAAC	0.587													31	27					5.45727e-16	1.01103e-15	1	0	T	26240858	T	T	26240858	3	4	138	1	0	0	0	0	1	0	0	0	7209	1174	41	2	207	2	HIST1H4F	6	26240858	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08		26240858	144874209	77	24824											
HIST1H3I	8354	broad.mit.edu	37	chr6	27840062	27840062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcggcgctttgccgccggtgGacttgcgagctgtttgcttt	2	13	15	11	5	0	0	0	0	0	0	0	2	0	1	2	3	4	4	2	3	0	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:27840062G>A	uc003njy.2	-	1	38	c.32C>T	c.(31-33)TCC>TTC	p.S11F		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	11					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GCCGCCGGTGGACTTGCGAGC	0.587													5	36					0	0	0	0	A	27840062	A	A	27840062	3	1	138	1	0	0	0	0	1	0	0	0	7202	1174	41	2	382	2	HIST1H3I	6	27840062	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	1599204	27840062	143275005	78	24825											
ITPR3	3710	broad.mit.edu	37	chr6	33653966	33653966	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catcaatgaggacaacgtggGcctcgtcatccagaccttgg	10	8	11	12	2	2	2	2	1	0	1	4	3	3	3	3	3	1	0	3	3	2	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:33653966G>A	uc011drk.1	+	42	6023	c.5804G>A	c.(5803-5805)GGC>GAC	p.G1935D	ITPR3_uc003oey.2_Missense_Mutation_p.G22D	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1935	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GACAACGTGGGCCTCGTCATC	0.612													6	22					0	0	0	0	A	33653966	A	A	33653966	3	1	138	1	0	0	0	0	1	0	0	0	7961	1203	42	4	5970	4	ITPR3	6	33653966	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	5813904	33653966	137461101	79	24826											
DNAH8	1769	broad.mit.edu	37	chr6	38831662	38831662	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgccaggtcttgcacagtcGggttcctggggctgttttga	5	13	14	9	1	1	1	0	1	1	0	3	1	2	1	2	4	2	4	2	4	0	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:38831662G>T	uc003ooe.1	+	43	6273	c.5673G>T	c.(5671-5673)TCG>TCT	p.S1891S		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTGCACAGTCGGGTTCCTGGG	0.358													10	51					0.00010058	0.000167001	1	0	T	38831662	T	T	38831662	2	4	138	1	0	0	0	0	0	0	0	1	4629	1103	39	3		3	DNAH8	6	38831662	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	5177696	38831662	132283405	80	24827											
ZNF318	24149	broad.mit.edu	37	chr6	43304974	43304974	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggcattccctgagggacCatattgtcttcaattacctg	9	13	8	11	0	3	1	2	1	1	0	4	2	4	2	3	2	1	1	3	2	3	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:43304974C>T	uc003oux.2	-	10	6840	c.6762G>A	c.(6760-6762)ATG>ATA	p.M2254I	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2254					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CCTGAGGGACCATATTGTCTT	0.463													15	30					0	0	0	0	T	43304974	T	T	43304974	3	4	138	1	0	0	0	0	1	0	0	0	17903	594	21	4	81	4	ZNF318	6	43304974	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	4473312	43304974	127810093	81	24828											
DST	667	broad.mit.edu	37	chr6	56495121	56495121	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacacagtttagtttcataGagttttacgagggcttctgc	9	15	9	8	1	3	1	2	0	1	1	3	2	3	1	0	1	2	4	0	1	3	7			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:56495121G>T	uc003pdf.2	-	30	4132	c.4104C>A	c.(4102-4104)CTC>CTA	p.L1368L	DST_uc003pcz.3_Silent_p.L1190L|DST_uc011dxj.1_Silent_p.L1219L|DST_uc011dxk.1_Silent_p.L1230L|DST_uc003pcy.3_Silent_p.L864L|DST_uc003pdb.2_Silent_p.L864L|DST_uc003pdc.3_Silent_p.L864L|DST_uc003pdd.3_Silent_p.L864L	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1190					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TAGTTTCATAGAGTTTTACGA	0.323													14	73					0.000151284	0.00025001	1	0	T	56495121	T	T	56495121	2	4	138	1	0	0	0	0	0	0	0	1	4805	929	33	2		2	DST	6	56495121	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	13190147	56495121	114619946	82	24829											
FUT9	10690	broad.mit.edu	37	chr6	96651372	96651372	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatccatcaccgagacatcaGttgggatctgacaaatttac	13	10	8	10	1	3	2	2	1	1	1	4	5	4	3	2	1	1	1	2	1	2	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:96651372G>C	uc003pop.3	+	3	682	c.341G>C	c.(340-342)AGT>ACT	p.S114T		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	114	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		CGAGACATCAGTTGGGATCTG	0.473													6	54					0	0	0	0	C	96651372	C	C	96651372	3	2	138	1	0	0	0	0	1	0	0	0	6145	1029	36	4	343	4	FUT9	6	96651372	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	40156251	96651372	74463695	83	24830											
SIM1	6492	broad.mit.edu	37	chr6	100895160	100895160	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacgtgaggacatagttgaCgctgacgatacagtgtggcc	10	9	13	9	3	1	3	1	3	0	0	1	5	1	4	1	2	1	2	1	2	2	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:100895160C>T	uc003pqj.3	-	8	1189	c.982G>A	c.(982-984)GTC>ATC	p.V328I	SIM1_uc010kcu.2_Missense_Mutation_p.V328I	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	328	PAC.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		ACATAGTTGACGCTGACGATA	0.627													4	31					0	0	0	0	T	100895160	T	T	100895160	3	4	138	1	0	0	0	0	1	0	0	0	14388	536	19	1	1334	1	SIM1	6	100895160	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	4243788	100895160	70219907	84	24831											
TFB1M	51106	broad.mit.edu	37	chr6	155581464	155581464	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atacattctgaaccacttttTccaccagcttgaatggctgc	10	13	6	12	0	1	2	0	2	1	0	2	2	2	2	3	1	4	2	3	1	3	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:155581464T>C	uc003qqj.3	-	6	801	c.737A>G	c.(736-738)GAA>GGA	p.E246G	TFB1M_uc003qqk.2_Intron	NM_016020	NP_057104	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			skin(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		AACCACTTTTTCCACCAGCTT	0.438													3	37					0	0	0	0	C	155581464	C	C	155581464	3	2	138	1	0	0	0	0	1	0	0	0	15859	1783	62	5	311	5	TFB1M	6	155581464	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	54686304	155581464	15533603	85	24832											
RAC1	5879	broad.mit.edu	37	chr7	6441634	6441634	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcccatcacctatccgcagGgtctagccatggctaaggag	9	8	10	14	1	2	0	1	0	1	0	4	1	4	1	4	3	1	2	4	3	3	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:6441634G>A	uc003spx.2	+	5	665	c.424G>A	c.(424-426)GGT>AGT	p.G142S	RAC1_uc003spw.2_Missense_Mutation_p.G161S	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	142					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	CTATCCGCAGGGTCTAGCCAT	0.463													5	154					0	0	0	0	A	6441634	A	A	6441634	3	1	138	1	0	0	0	0	1	0	0	0	13039	1232	43	4	503	4	RAC1	7	6441634	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08		6441634	152697029	86	24833											
THSD7A	221981	broad.mit.edu	37	chr7	11485699	11485699	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgaattaccatggctgttaCatctagatgtttccacaagc	11	14	7	9	0	1	2	0	1	1	1	2	2	2	2	2	1	3	3	2	1	5	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:11485699C>A	uc003ssf.3	-	13	3305	c.3053G>T	c.(3052-3054)TGT>TTT	p.C1018F		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1018	TSP type-1 10.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ATGGCTGTTACATCTAGATGT	0.423										HNSCC(18;0.044)			89	168					3.10062e-51	6.06344e-51	1	0	A	11485699	A	A	11485699	3	1	138	1	0	0	0	0	1	0	0	0	15945	478	17	4	1980	4	THSD7A	7	11485699	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	5044065	11485699	147652964	87	24834											
SEPT7	989	broad.mit.edu	37	chr7	35930338	35930338	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cactatgagaactacagaagCagaaaacttgcagctgtgac	16	7	9	9	0	0	4	0	2	0	3	0	5	0	4	0	0	6	3	0	0	6	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:35930338C>T	uc010kxc.2	+	10	1126	c.933C>T	c.(931-933)AGC>AGT	p.S311S	SEPT7_uc011kat.1_Silent_p.S310S|SEPT7_uc011kau.1_Silent_p.S275S|SEPT7_uc011kav.1_Silent_p.S258S|SEPT7_uc003tey.2_Silent_p.S159S	NM_001788	NP_001779	Q16181	SEPT7_HUMAN	cell division cycle 10 isoform 1	311					cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity				0						ACTACAGAAGCAGAAAACTTG	0.333													4	34					0	0	0	0	T	35930338	T	T	35930338	2	4	138	1	0	0	0	0	0	0	0	1	14134	709	25	4		4	SEPT7	7	35930338	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	24444639	35930338	123208325	88	24835											
VPS41	27072	broad.mit.edu	37	chr7	38765891	38765891	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttcctggtccacggttcttAgcactgcagatgttgcagaa	8	12	10	11	1	1	2	0	0	1	2	3	2	3	2	2	2	3	5	2	2	2	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:38765891A>C	uc003tgy.2	-	29	2546	c.2520T>G	c.(2518-2520)GCT>GCG	p.A840A	VPS41_uc003tgz.2_Silent_p.A815A|VPS41_uc010kxn.2_Silent_p.A751A|VPS41_uc003tgx.2_RNA	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	840					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						CACGGTTCTTAGCACTGCAGA	0.363													17	24					0	0	0	0	C	38765891	C	C	38765891	2	2	138	1	0	0	0	0	0	0	0	1	17278	407	15	5		5	VPS41	7	38765891	Silent	SNP	A	TCGA-CR-7367-01A-11D-2012-08	2835553	38765891	120372772	89	24836											
POM121L12	285877	broad.mit.edu	37	chr7	53104113	53104113	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcctcagtttttgtgatgAtgcttggccttccgtgctgg	4	15	13	9	1	1	2	1	2	0	0	2	3	2	2	3	2	3	3	3	2	0	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:53104113A>T	uc003tpz.2	+	1	765	c.749A>T	c.(748-750)GAT>GTT	p.D250V		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	250											0						TTTTGTGATGATGCTTGGCCT	0.627													19	97					0	0	0	0	T	53104113	T	T	53104113	3	4	138	1	0	0	0	0	1	0	0	0	12296	333	12	5	751	5	POM121L12	7	53104113	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	14338222	53104113	106034550	90	24837											
ZNF117	51351	broad.mit.edu	37	chr7	64438853	64438853	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggttaaaggctttgccacAttctccacatttgtagggtt	8	15	9	9	0	1	0	0	0	1	0	2	0	1	0	2	3	1	4	2	3	3	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:64438853A>T	uc003ttr.2	-	4	2381	c.1096T>A	c.(1096-1098)TGT>AGT	p.C366S		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	366	C2H2-type 10.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				GCTTTGCCACATTCTCCACAT	0.398													11	65					0	0	0	0	T	64438853	T	T	64438853	3	4	138	1	0	0	0	0	1	0	0	0	17784	217	8	5	359	5	ZNF117	7	64438853	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	11334740	64438853	94699810	91	24838											
GRM3	2913	broad.mit.edu	37	chr7	86416016	86416016	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgggtggccagcgacggctGgggcgcgcaggagagcatca	7	4	19	11	4	1	1	1	0	0	1	1	3	1	1	1	6	2	3	1	6	0	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:86416016G>A	uc003uid.2	+	3	2007	c.908G>A	c.(907-909)TGG>TAG	p.W303*	GRM3_uc010lef.2_Nonsense_Mutation_p.W301*|GRM3_uc010leg.2_Nonsense_Mutation_p.W175*|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	303	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AGCGACGGCTGGGGCGCGCAG	0.687													9	38					0	0	0	0	A	86416016	A	A	86416016	4	1	138	1	0	0	0	0	0	1	0	0	6837	1357	47	4	914	4	GRM3	7	86416016	Nonsense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	21977163	86416016	72722647	92	24839											
GNG11	2791	broad.mit.edu	37	chr7	93555441	93555441	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaataaagaactatattgaAgaacgttctggagaggatcc	17	9	10	5	1	1	4	0	1	1	3	2	7	2	5	1	2	2	1	1	2	8	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:93555441A>T	uc003und.2	+	2	569	c.135A>T	c.(133-135)GAA>GAT	p.E45D		NM_004126	NP_004117	P61952	GBG11_HUMAN	guanine nucleotide binding protein gamma 11	45					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway	heterotrimeric G-protein complex	GTPase activity|signal transducer activity			kidney(1)	1	all_cancers(62;2.39e-10)|all_epithelial(64;1.54e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			ACTATATTGAAGAACGTTCTG	0.348													22	81					0	0	0	0	T	93555441	T	T	93555441	3	4	138	1	0	0	0	0	1	0	0	0	6561	69	3	5	141	5	GNG11	7	93555441	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	7139425	93555441	65583222	93	24840											
CADPS2	93664	broad.mit.edu	37	chr7	122153341	122153341	+	Frame_Shift_Del	DEL	A	-	-																															acgttttttccatcttttccAaaccttctgtccaagggcat																										TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:122153341delA	uc010lkp.2	-	9	1667	c.1504delT	c.(1504-1506)TGGfs	p.W502fs	CADPS2_uc003vkg.3_Frame_Shift_Del_p.W202fs|CADPS2_uc010lkq.2_Frame_Shift_Del_p.W502fs	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	502	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						CATCTTTTCCAAACCTTCTGT	0.313													---	---	---								-	122153341	-	-	122153341	7	5	138	1	0	1	0	1	0	0	0	0	2583	130	5	0	2518	0	CADPS2	7	122153341	Frame_Shift_Del	DEL	A	TCGA-CR-7367-01A-11D-2012-08	28597900	122153341	36985322	94	24841											
EXOC4	60412	broad.mit.edu	37	chr7	133160110	133160110	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aactgagtacttggatatgaAaaatactcgtacggcctctg	13	11	9	8	2	1	2	0	2	1	0	2	3	1	3	1	2	4	2	1	2	7	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:133160110A>T	uc003vrk.2	+	8	1246	c.1211A>T	c.(1210-1212)AAA>ATA	p.K404I	EXOC4_uc011kpo.1_Missense_Mutation_p.K303I|EXOC4_uc003vri.2_Missense_Mutation_p.K404I|EXOC4_uc003vrj.2_Missense_Mutation_p.K404I	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	404					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				TTGGATATGAAAAATACTCGT	0.363													10	99					0	0	0	0	T	133160110	T	T	133160110	3	4	138	1	0	0	0	0	1	0	0	0	5330	14	1	5	1241	5	EXOC4	7	133160110	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	11006769	133160110	25978553	95	24842											
KIAA1549	57670	broad.mit.edu	37	chr7	138583773	138583773	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggtccattttgttaatcaGgtccgaagacttgactgcac	10	12	10	9	1	1	2	1	1	0	1	3	4	3	2	2	2	1	2	2	2	2	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:138583773G>A	uc011kql.1	-	9	3824	c.3775C>T	c.(3775-3777)CTG>TTG	p.L1259L	KIAA1549_uc011kqi.1_Silent_p.L43L|KIAA1549_uc003vuk.3_Silent_p.L1209L|KIAA1549_uc011kqj.1_Silent_p.L1259L|KIAA1549_uc011kqk.1_Silent_p.L43L	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1259						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TTGTTAATCAGGTCCGAAGAC	0.493			O	BRAF	pilocytic astrocytoma								15	133					0	0	0	0	A	138583773	A	A	138583773	2	1	138	1	0	0	0	0	0	0	0	1	8283	991	35	4		4	KIAA1549	7	138583773	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	5423663	138583773	20554890	96	24843											
TBXAS1	6916	broad.mit.edu	37	chr7	139715537	139715537	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcagattcacacgggaggCagctcaggactgcgaggtgc	9	6	14	12	2	3	1	3	0	0	1	3	4	3	3	1	4	3	2	1	4	0	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:139715537C>A	uc011kqv.1	+	12	1546	c.1382C>A	c.(1381-1383)GCA>GAA	p.A461E	TBXAS1_uc003vvh.2_Missense_Mutation_p.A415E|TBXAS1_uc010lne.2_Missense_Mutation_p.A347E|TBXAS1_uc011kqu.1_Missense_Mutation_p.A366E|TBXAS1_uc003vvi.2_Missense_Mutation_p.A415E|TBXAS1_uc003vvj.2_Missense_Mutation_p.A415E|TBXAS1_uc011kqw.1_Missense_Mutation_p.A395E	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	414	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					ACACGGGAGGCAGCTCAGGAC	0.642													8	80					0.000274275	0.000446967	1	0	A	139715537	A	A	139715537	3	1	138	1	0	0	0	0	1	0	0	0	15730	710	25	4	1428	4	TBXAS1	7	139715537	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	1131764	139715537	19423126	97	24844											
PARP12	64761	broad.mit.edu	37	chr7	139724438	139724438	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcttggaggaggtggtgtaCtggatgacatactctgggta	8	11	17	5	0	1	1	0	1	1	0	1	4	1	4	0	7	2	3	0	7	3	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:139724438C>T	uc003vvl.1	-	12	2902	c.2028G>A	c.(2026-2028)CAG>CAA	p.Q676Q	PARP12_uc003vvk.1_Silent_p.Q462Q|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	676	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					AGGTGGTGTACTGGATGACAT	0.572													10	52					0	0	0	0	T	139724438	T	T	139724438	2	4	138	1	0	0	0	0	0	0	0	1	11511	564	20	4		4	PARP12	7	139724438	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	8901	139724438	19414225	98	24845											
TRPV5	56302	broad.mit.edu	37	chr7	142612693	142612693	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccccaacgatgctcaccaGctcccccaccagcctgatga	10	5	7	19	1	1	2	1	2	0	0	2	3	2	2	7	0	5	2	7	0	1	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:142612693G>A	uc003wby.1	-	9	1432	c.1168C>T	c.(1168-1170)CTG>TTG	p.L390L		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	390	Helical; (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					ATGCTCACCAGCTCCCCCACC	0.547													5	40					0	0	0	0	A	142612693	A	A	142612693	2	1	138	1	0	0	0	0	0	0	0	1	16666	962	34	4		4	TRPV5	7	142612693	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	2888255	142612693	16525970	99	24846											
PAXIP1	22976	broad.mit.edu	37	chr7	154738231	154738231	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaaacgtacctatgcctcTggcaaaatattctcggcata	12	10	9	10	2	2	0	0	0	2	0	3	1	2	1	2	3	3	3	2	3	7	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:154738231T>G	uc003wlp.2	-	19	3167	c.3124A>C	c.(3124-3126)AGA>CGA	p.R1042R	LOC100132707_uc011kvr.1_Intron|LOC100132707_uc003wlo.2_Intron|PAXIP1_uc003wlq.1_Silent_p.R1008R|PAXIP1_uc011kvs.1_Silent_p.R1006R	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	1042	Interaction with TP53BP1.|BRCT 6.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		CCTATGCCTCTGGCAAAATAT	0.413													3	46					0	0	0	0	G	154738231	G	G	154738231	2	3	138	1	0	0	0	0	0	0	0	1	11541	1588	55	5		5	PAXIP1	7	154738231	Silent	SNP	T	TCGA-CR-7367-01A-11D-2012-08	12125538	154738231	4400432	100	24847											
WRN	7486	broad.mit.edu	37	chr8	30977861	30977861	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acatggaatcatattatcagGagattggtagagctggtcgt	12	12	12	5	1	2	2	2	0	0	2	3	4	2	3	0	4	1	2	0	4	4	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr8:30977861G>T	uc003xio.3	+	21	3339	c.2551G>T	c.(2551-2553)GAG>TAG	p.E851*	WRN_uc010lvk.2_Nonsense_Mutation_p.E318*	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	851	Helicase C-terminal.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		ATATTATCAGGAGATTGGTAG	0.393			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				18	102					3.41278e-10	6.0065e-10	1	0	T	30977861	T	T	30977861	4	4	138	1	0	0	0	0	0	1	0	0	17470	1175	41	2	2629	2	WRN	8	30977861	Nonsense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08		30977861	115386161	101	24848											
PXDNL	137902	broad.mit.edu	37	chr8	52284568	52284569	+	Missense_Mutation	DNP	CC	AA	AA																															gtcaccattgtcacaaagcaCccggctcagggacgcctgct																										TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr8:52284568_52284569CC>AA	uc003xqu.3	-	19	3866_3867	c.3765_3766GG>TT	c.(3763-3768)CGGGTG>CGTTTG	p.V1256L	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1256					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TCACAAAGCACCCGGCTCAGGG	0.49													18	17					0	0	0	0	AA	52284569	AA	AA	52284568	3	1	138	1	0	0	0	0	1	0	0	0	12913	507	18	4	645	4	PXDNL	8	52284568	Missense_Mutation	DNP	CC	TCGA-CR-7367-01A-11D-2012-08	21306707	52284568	94079454	102	24849											
SLC26A7	115111	broad.mit.edu	37	chr8	92401664	92401664	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggagtctccatgcttgttGaggtatttatggaacttgtg	7	16	12	6	0	1	1	0	1	1	0	2	3	1	3	1	3	2	3	1	3	3	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr8:92401664G>A	uc003yex.2	+	17	2052	c.1774G>A	c.(1774-1776)GAG>AAG	p.E592K	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.E592K|SLC26A7_uc003yfa.2_Missense_Mutation_p.E592K	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	592	STAS.|Cytoplasmic (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CATGCTTGTTGAGGTATTTAT	0.413													57	107					0	0	0	0	A	92401664	A	A	92401664	3	1	138	1	0	0	0	0	1	0	0	0	14586	1291	45	2	1832	2	SLC26A7	8	92401664	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	40117096	92401664	53962358	103	24850											
CSMD3	114788	broad.mit.edu	37	chr8	113241018	113241018	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gataaaatccaaatcctgcaAatataagtgcaaaaaaaggc	21	7	6	7	0	0	0	0	0	0	0	2	1	2	0	2	1	2	2	2	1	9	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr8:113241018A>G	uc003ynu.2	-	70	11090	c.10931T>C	c.(10930-10932)TTT>TCT	p.F3644S	CSMD3_uc003yns.2_Missense_Mutation_p.F2846S|CSMD3_uc003ynt.2_Missense_Mutation_p.F3604S|CSMD3_uc011lhx.1_Missense_Mutation_p.F3475S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3644	Helical; (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAATCCTGCAAATATAAGTGC	0.313										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			38	34					0	0	0	0	G	113241018	G	G	113241018	3	3	138	1	0	0	0	0	1	0	0	0	3963	14	1	5	200	5	CSMD3	8	113241018	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	20839354	113241018	33123004	104	24851											
EIF2C2	27161	broad.mit.edu	37	chr8	141570572	141570572	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagagggttagagcagccttCggacgcggtgaagaaggagc	12	5	17	7	3	0	4	0	1	0	3	1	6	0	6	1	4	3	2	1	4	4	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr8:141570572C>T	uc003yvn.2	-	5	596	c.556G>A	c.(556-558)GAA>AAA	p.E186K	EIF2C2_uc010men.2_Missense_Mutation_p.E109K|EIF2C2_uc010meo.2_Missense_Mutation_p.E186K	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	186					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			GAGCAGCCTTCGGACGCGGTG	0.597													46	78					0	0	0	0	T	141570572	T	T	141570572	3	4	138	1	0	0	0	0	1	0	0	0	5028	893	31	1	2083	1	EIF2C2	8	141570572	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	28329554	141570572	4793450	105	24852											
SLC46A2	57864	broad.mit.edu	37	chr9	115652267	115652267	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctggctgggtttggccaccGactcagggacctttagcacc	6	9	12	14	1	1	0	1	0	0	0	1	2	1	1	5	4	1	3	5	4	1	3	rs140881150		TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr9:115652267G>A	uc004bgk.2	-	1	927	c.695C>T	c.(694-696)TCG>TTG	p.S232L		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	232	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						TTTGGCCACCGACTCAGGGAC	0.607													13	41					0	0	0	0	A	115652267	A	A	115652267	3	1	138	1	0	0	0	0	1	0	0	0	14709	1059	37	1	748	1	SLC46A2	9	115652267	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08		115652267	25561164	106	24853											
ASTN2	23245	broad.mit.edu	37	chr9	119976974	119976974	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caacgtcgctgggcgtacagCgccacggtgaacaccagcag	10	4	13	14	5	0	1	0	1	0	0	1	1	0	1	2	2	5	3	2	2	3	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr9:119976974C>A	uc004bjs.1	-	3	779	c.678G>T	c.(676-678)GCG>GCT	p.A226A	ASTN2_uc004bjr.1_Silent_p.A226A|ASTN2_uc004bjt.1_Silent_p.A226A	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	226	Helical; (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GGGCGTACAGCGCCACGGTGA	0.602													25	29					4.7796e-09	8.32881e-09	1	0	A	119976974	A	A	119976974	2	1	138	1	0	0	0	0	0	0	0	1	1067	755	27	3		3	ASTN2	9	119976974	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	4324707	119976974	21236457	107	24854											
UCK1	83549	broad.mit.edu	37	chr9	134404963	134404963	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgtgcatcaaatcattatCaaaggcatctgcagggttgg	11	11	10	9	0	4	0	3	0	1	0	4	0	4	0	1	3	2	4	1	3	3	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr9:134404963C>G	uc004cay.2	-	3	378	c.277G>C	c.(277-279)GAT>CAT	p.D93H	UCK1_uc010mzk.2_Missense_Mutation_p.D84H|UCK1_uc004cba.2_Missense_Mutation_p.D93H|UCK1_uc004caz.2_RNA	NM_031432	NP_113620	Q9HA47	UCK1_HUMAN	uridine-cytidine kinase 1 isoform a	93					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;2.34e-05)|Epithelial(140;0.000219)		AAATCATTATCAAAGGCATCT	0.547													17	91					0	0	0	0	G	134404963	G	G	134404963	3	3	138	1	0	0	0	0	1	0	0	0	16991	826	29	2	576	2	UCK1	9	134404963	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	14427989	134404963	6808468	108	24855											
WDR5	11091	broad.mit.edu	37	chr9	137017113	137017113	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgcttcgaagtcgcatctGggacaccgcctcaggccagt	7	10	11	13	3	2	0	1	0	1	0	4	2	2	1	3	2	1	2	3	2	1	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr9:137017113G>A	uc004cey.2	+	9	764	c.593G>A	c.(592-594)TGG>TAG	p.W198*	WDR5_uc004cez.2_Nonsense_Mutation_p.W198*	NM_017588	NP_060058	P61964	WDR5_HUMAN	WD repeat domain 5	198	WD 4.				histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding				0		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		AGTCGCATCTGGGACACCGCC	0.557													17	160					0	0	0	0	A	137017113	A	A	137017113	4	1	138	1	0	0	0	0	0	1	0	0	17371	1357	47	4	623	4	WDR5	9	137017113	Nonsense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	2612150	137017113	4196318	109	24856											
ADARB2	105	broad.mit.edu	37	chr10	1405839	1405839	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaccgctaccgcgaagaccGgggcatgcaccgggcccgtc	7	3	13	18	6	0	1	0	0	0	1	1	2	0	1	6	3	2	3	6	3	2	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:1405839G>T	uc009xhq.2	-	3	835	c.461C>A	c.(460-462)CCG>CAG	p.P154Q		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	154	DRBM 1.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CGCGAAGACCGGGGCATGCAC	0.692													3	28					0.00024832	0.000408452	1	0	T	1405839	T	T	1405839	3	4	138	1	0	0	0	0	1	0	0	0	283	1116	39	3	1790	3	ADARB2	10	1405839	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08		1405839	134128908	110	24857											
ACBD5	91452	broad.mit.edu	37	chr10	27493384	27493384	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttaccttctccttctttgaTagtataaatacaccaaccac	12	14	2	13	0	2	1	0	1	2	0	3	1	2	1	4	0	3	1	4	0	7	8			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:27493384T>C	uc010qdp.1	-	12	1741	c.1550A>G	c.(1549-1551)TAT>TGT	p.Y517C	ACBD5_uc010qdm.1_Missense_Mutation_p.Y515C|ACBD5_uc010qdn.1_Missense_Mutation_p.Y408C|ACBD5_uc010qdo.1_Missense_Mutation_p.Y340C|ACBD5_uc001ito.2_Missense_Mutation_p.Y482C|ACBD5_uc001itp.2_Missense_Mutation_p.Y408C|ACBD5_uc001itq.2_Missense_Mutation_p.Y408C|ACBD5_uc001itr.1_Missense_Mutation_p.Y306C	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	526	Helical; (Potential).				transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						CCTTCTTTGATAGTATAAATA	0.413													6	32					0	0	0	0	C	27493384	C	C	27493384	3	2	138	1	0	0	0	0	1	0	0	0	125	1406	49	5	35	5	ACBD5	10	27493384	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	26087545	27493384	108041363	111	24858											
ASAH2	56624	broad.mit.edu	37	chr10	52005019	52005019	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgtcctgtgcagtcagctCgtccaacaccaatatggtag	9	11	9	12	1	1	0	1	0	0	0	4	0	3	0	3	1	3	3	3	1	4	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:52005019C>T	uc001jjd.2	-	2	323	c.323G>A	c.(322-324)CGA>CAA	p.R108Q	ASAH2_uc009xos.2_Missense_Mutation_p.R108Q	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	108	Lumenal (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						GCAGTCAGCTCGTCCAACACC	0.448													34	210					0	0	0	0	T	52005019	T	T	52005019	3	4	138	1	0	0	0	0	1	0	0	0	1009	884	31	1	2095	1	ASAH2	10	52005019	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	24511635	52005019	83529728	112	24859											
UNC5B	219699	broad.mit.edu	37	chr10	73057778	73057778	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catccgccagaagatatgcaAcagcctagatgcccccaact	13	6	7	15	1	0	3	0	0	0	3	1	3	1	3	5	0	5	1	5	0	5	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:73057778A>G	uc001jro.2	+	16	3048	c.2603A>G	c.(2602-2604)AAC>AGC	p.N868S	UNC5B_uc001jrp.2_Missense_Mutation_p.N857S|UNC5B_uc001jrq.1_5'Flank	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	868	Cytoplasmic (Potential).|Death.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						AAGATATGCAACAGCCTAGAT	0.572													8	55					0	0	0	0	G	73057778	G	G	73057778	3	3	138	1	0	0	0	0	1	0	0	0	17060	43	2	5	2665	5	UNC5B	10	73057778	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	21052759	73057778	62476969	113	24860											
LRIT1	26103	broad.mit.edu	37	chr10	86001255	86001256	+	5'Flank	INS	-	GCCCAGCAA	GCCCAGCAA																															tggaccgctccgtcccaccgINSgcccagcaagctcagcagct																								rs142133495	by1000genomes	TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:86001255_86001256insGCCCAGCAA	uc001kcz.1	-						LRIT1_uc001kda.1_RNA	NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL							integral to endoplasmic reticulum membrane					0						CCGTCCCACCGGCCCAGCAAGC	0.653													---	---	---								GCCCAGCAA	86001256	GCCCAGCAA	GCCCAGCAA	86001255	6	5	138	0	1	1	1	0	0	0	0	0	8997	1131	39	0		0	LRIT1	10	86001255	5'Flank	INS	-	TCGA-CR-7367-01A-11D-2012-08	12943477	86001255	49533492	114	24861											
MKI67	4288	broad.mit.edu	37	chr10	129913914	129913914	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtaggacattttcttttTgtgattttacatccaactct	9	19	5	8	0	2	1	0	1	2	0	3	2	3	2	1	1	2	1	1	1	3	7			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:129913914T>G	uc001lke.2	-	7	953	c.758A>C	c.(757-759)CAA>CCA	p.Q253P	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	253					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ATTTTCTTTTTGTGATTTTAC	0.373													4	55					0	0	0	0	G	129913914	G	G	129913914	3	3	138	1	0	0	0	0	1	0	0	0	9651	1812	63	5	9048	5	MKI67	10	129913914	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	43912659	129913914	5620833	115	24862											
MGMT	4255	broad.mit.edu	37	chr10	131565165	131565165	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccatgaaggccaccggttGgggaagccaggcttgggagg	8	5	18	10	1	0	1	0	1	0	0	0	3	0	3	4	7	1	2	4	7	2	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:131565165G>T	uc001lkh.2	+	5	647	c.621G>T	c.(619-621)TTG>TTT	p.L207F		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	176										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		GCCACCGGTTGGGGAAGCCAG	0.662								Direct_reversal_of_damage					8	25					1.06961e-07	1.8366e-07	1	0	T	131565165	T	T	131565165	3	4	138	1	0	0	0	0	1	0	0	0	9610	1339	47	4	639	4	MGMT	10	131565165	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	1651251	131565165	3969582	116	24863											
LRRC56	115399	broad.mit.edu	37	chr11	554064	554064	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcggtggtcgacagacctgCagtccagggggcgtcggctc	5	6	17	13	5	0	1	0	0	0	1	4	2	1	1	2	5	1	2	2	5	0	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:554064C>A	uc010qvz.1	+	14	1922	c.1417C>A	c.(1417-1419)CAG>AAG	p.Q473K		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	473										skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GACAGACCTGCAGTCCAGGGG	0.701													17	96					9.16793e-09	1.58192e-08	1	0	A	554064	A	A	554064	3	1	138	1	0	0	0	0	1	0	0	0	9062	711	25	4	1459	4	LRRC56	11	554064	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08		554064	134452452	117	24864											
OR51V1	283111	broad.mit.edu	37	chr11	5221490	5221490	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaattttgataattctggaAttagtcaggatggaggaata	14	13	10	4	0	2	1	1	1	1	0	2	5	2	5	1	4	0	0	1	4	6	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:5221490A>C	uc010qyz.1	-	1	441	c.441T>G	c.(439-441)AAT>AAG	p.N147K		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	147	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAATTCTGGAATTAGTCAGGA	0.398													6	47					0	0	0	0	C	5221490	C	C	5221490	3	2	138	1	0	0	0	0	1	0	0	0	11161	98	4	5	527	5	OR51V1	11	5221490	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	4667426	5221490	129785026	118	24865											
ANO3	63982	broad.mit.edu	37	chr11	26529781	26529781	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacatttgaaaagaacctcaGagcagaaggcttgatgttgg	14	9	11	7	0	1	5	1	2	0	3	1	5	1	5	1	2	2	3	1	2	4	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:26529781G>A	uc001mqt.3	+	5	708	c.563G>A	c.(562-564)AGA>AAA	p.R188K	ANO3_uc010rdr.1_Missense_Mutation_p.R172K|ANO3_uc010rds.1_Missense_Mutation_p.R42K|ANO3_uc010rdt.1_Missense_Mutation_p.R42K	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	188	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAGAACCTCAGAGCAGAAGGC	0.318													7	43					0	0	0	0	A	26529781	A	A	26529781	3	1	138	1	0	0	0	0	1	0	0	0	698	942	33	2	581	2	ANO3	11	26529781	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	21308291	26529781	108476735	119	24866											
OR5M11	219487	broad.mit.edu	37	chr11	56310671	56310671	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaagcagagactggagttcCgggcaatctgtgagcccaag	13	6	13	9	1	1	2	0	1	1	1	2	4	2	3	2	2	2	3	2	2	4	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:56310671C>T	uc010rjl.1	-	1	63	c.63G>A	c.(61-63)CCG>CCA	p.P21P		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTGGAGTTCCGGGCAATCTG	0.458													10	110					0	0	0	0	T	56310671	T	T	56310671	2	4	138	1	0	0	0	0	0	0	0	1	11228	639	23	1		1	OR5M11	11	56310671	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	29780890	56310671	78695845	120	24867											
TNKS1BP1	85456	broad.mit.edu	37	chr11	57085295	57085295	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggaggataactcacatcAgcaggtagctccgagctggc	11	7	12	11	1	2	0	2	0	0	0	3	3	3	2	1	4	4	4	1	4	2	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:57085295A>G	uc001njr.2	-	3	1107	c.795T>C	c.(793-795)GCT>GCC	p.A265A	TNKS1BP1_uc001njs.2_Silent_p.A265A|TNKS1BP1_uc009ymd.1_5'UTR	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	265	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				AACTCACATCAGCAGGTAGCT	0.358													8	23					0	0	0	0	G	57085295	G	G	57085295	2	3	138	1	0	0	0	0	0	0	0	1	16386	175	7	5		5	TNKS1BP1	11	57085295	Silent	SNP	A	TCGA-CR-7367-01A-11D-2012-08	774624	57085295	77921221	121	24868											
CTNND1	1500	broad.mit.edu	37	chr11	57582974	57582974	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggaacaacacccttgatggTaaattctctttatatactgc	12	13	7	9	0	1	1	0	1	1	0	2	2	1	2	1	2	4	1	1	2	7	7			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:57582974T>C	uc001nmc.3	+	19	3379	c.2808_splice	c.e19+2	p.M936_splice	CTNND1_uc001nlh.1_Splice_Site_p.M936_splice|CTNND1_uc001nlu.3_Splice_Site_p.M829_splice|CTNND1_uc001nlt.3_Splice_Site_p.M829_splice|CTNND1_uc001nls.3_Splice_Site_p.M808_splice|CTNND1_uc001nlw.3_Splice_Site_p.M829_splice|CTNND1_uc001nmf.3_Splice_Site_p.M936_splice|CTNND1_uc001nmd.3_Splice_Site_p.M882_splice|CTNND1_uc001nlk.3_Splice_Site_p.M882_splice|CTNND1_uc001nme.3_Splice_Site_p.M930_splice|CTNND1_uc001nll.3_Splice_Site_p.M876_splice|CTNND1_uc001nmg.3_Splice_Site_p.M876_splice|CTNND1_uc001nlj.3_Splice_Site_p.M876_splice|CTNND1_uc001nlr.3_Splice_Site_p.M876_splice|CTNND1_uc001nlp.3_Splice_Site_p.M855_splice|CTNND1_uc001nlx.3_Splice_Site_p.M613_splice|CTNND1_uc001nlz.3_Splice_Site_p.M613_splice|CTNND1_uc009ymn.2_Splice_Site_p.M607_splice|CTNND1_uc001nlm.3_Splice_Site_p.M930_splice|CTNND1_uc001nly.3_Splice_Site_p.M607_splice|CTNND1_uc001nmb.3_Splice_Site_p.M607_splice|CTNND1_uc001nma.3_Splice_Site_p.M586_splice|CTNND1_uc001nmi.3_Splice_Site_p.M835_splice|CTNND1_uc001nmh.3_Splice_Site_p.M930_splice|CTNND1_uc001nlq.3_Splice_Site_p.M835_splice|CTNND1_uc001nln.3_Splice_Site_p.M930_splice|CTNND1_uc001nli.3_Splice_Site_p.M909_splice|CTNND1_uc001nlo.3_Splice_Site_p.M829_splice|CTNND1_uc001nlv.3_Splice_Site_p.M829_splice	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC						adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				CCCTTGATGGTAAATTCTCTT	0.413													3	20					0	0	0	0	C	57582974	C	C	57582974	5	2	138	1	0	0	0	0	0	0	1	0	4036	1652	57	5	2876	5	CTNND1	11	57582974	Splice_Site	SNP	T	TCGA-CR-7367-01A-11D-2012-08	497679	57582974	77423542	122	24869											
B3GAT3	26229	broad.mit.edu	37	chr11	62388037	62388038	+	Frame_Shift_Ins	INS	-	G	G																															cagggggctgggcaggggcaINSgggggtggccgtcggagttc																										TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:62388037_62388038insG	uc001ntw.2	-	2	217_218	c.188_189insC	c.(187-189)CCTfs	p.P63fs	B3GAT3_uc009ynz.2_Frame_Shift_Ins_p.P56fs|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Frame_Shift_Ins_p.P63fs	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	63	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						GGGCAGGGGCAGGGGGTGGCCG	0.634													---	---	---								G	62388038	G	G	62388037	7	5	138	1	0	1	1	0	0	0	0	0	1257	175	7	0	834	0	B3GAT3	11	62388037	Frame_Shift_Ins	INS	-	TCGA-CR-7367-01A-11D-2012-08	4805063	62388037	72618479	123	24870											
NUMA1	4926	broad.mit.edu	37	chr11	71729904	71729904	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgcggttctcagctagcTccagctccagctcatcccta	6	11	8	16	1	2	0	2	0	1	0	6	0	5	0	3	1	5	6	3	1	2	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:71729904T>A	uc001orl.1	-	10	879	c.707A>T	c.(706-708)GAG>GTG	p.E236V	NUMA1_uc009ysw.1_5'Flank|NUMA1_uc001ork.1_Missense_Mutation_p.E236V|NUMA1_uc001orm.1_Missense_Mutation_p.E236V|NUMA1_uc001orn.2_5'Flank|NUMA1_uc009ysx.1_Missense_Mutation_p.E236V|NUMA1_uc001oro.1_Missense_Mutation_p.E236V|NUMA1_uc009ysy.1_Missense_Mutation_p.E236V|NUMA1_uc001orp.2_Missense_Mutation_p.E236V|NUMA1_uc001orq.2_Missense_Mutation_p.E236V	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	236	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CTCAGCTAGCTCCAGCTCCAG	0.562			T	RARA	APL								22	110					0	0	0	0	A	71729904	A	A	71729904	3	1	138	1	0	0	0	0	1	0	0	0	10804	1551	54	5	5712	5	NUMA1	11	71729904	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	9341867	71729904	63276612	124	24871											
RELT	84957	broad.mit.edu	37	chr11	73106507	73106507	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagaaccgctatgtggtcCggctaagtgagagcaacctg	11	7	14	9	2	0	2	0	1	0	2	1	4	1	2	3	3	3	3	3	3	4	2	rs139368769	byFrequency	TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:73106507C>T	uc001otv.2	+	11	1429	c.1264C>T	c.(1264-1266)CGG>TGG	p.R422W	RELT_uc001otw.2_Missense_Mutation_p.R422W|RELT_uc001otx.2_RNA	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	422	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						ctatgtggtccggctaagtga	0.129													17	82					0	0	0	0	T	73106507	T	T	73106507	3	4	138	1	0	0	0	0	1	0	0	0	13286	643	23	1	1302	1	RELT	11	73106507	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	1376603	73106507	61900009	125	24872											
PIWIL4	143689	broad.mit.edu	37	chr11	94341767	94341767	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agttaaagtccctgatggtgGtcggtattgatgtctgtaaa	10	14	12	5	1	1	2	0	2	1	0	3	2	2	2	1	3	0	3	1	3	5	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:94341767G>A	uc001pfa.2	+	15	2069	c.1858G>A	c.(1858-1860)GTC>ATC	p.V620I	PIWIL4_uc010rue.1_Intron|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	620	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCTGATGGTGGTCGGTATTGA	0.388													33	102					0	0	0	0	A	94341767	A	A	94341767	3	1	138	1	0	0	0	0	1	0	0	0	12015	1261	44	4	1916	4	PIWIL4	11	94341767	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	21235260	94341767	40664749	126	24873											
OR6X1	390260	broad.mit.edu	37	chr11	123624803	123624803	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacccaggagctcagggccaGctgcaggcagagtttgctgg	8	6	15	12	0	1	1	1	0	0	1	1	2	1	2	2	4	4	6	2	4	0	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:123624803G>T	uc010rzy.1	-	1	424	c.424C>A	c.(424-426)CTG>ATG	p.L142M		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CTCAGGGCCAGCTGCAGGCAG	0.507													12	74					6.81908e-15	1.25671e-14	1	0	T	123624803	T	T	123624803	3	4	138	1	0	0	0	0	1	0	0	0	11266	962	34	4	516	4	OR6X1	11	123624803	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	29283036	123624803	11381713	127	24874											
ANO2	57101	broad.mit.edu	37	chr12	5685021	5685021	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagaactgaacctcctggTcaaactgtgagttttctggc	9	12	10	10	0	2	3	1	2	1	1	3	3	3	3	2	2	4	2	2	2	3	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:5685021T>C	uc001qnm.2	-	24	2672	c.2600A>G	c.(2599-2601)GAC>GGC	p.D867G		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	872	Extracellular (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						AACCTCCTGGTCAAACTGTGA	0.493													5	40					0	0	0	0	C	5685021	C	C	5685021	3	2	138	1	0	0	0	0	1	0	0	0	697	1667	58	5	408	5	ANO2	12	5685021	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08		5685021	128166874	128	24875											
ATN1	1822	broad.mit.edu	37	chr12	7048173	7048173	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agccctgcggcctgacatgtCctatgctgagcggctggcag	6	8	14	13	2	0	2	0	2	0	0	1	2	1	2	3	3	4	3	3	3	1	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:7048173C>A	uc001qrw.1	+	7	3284	c.3047C>A	c.(3046-3048)TCC>TAC	p.S1016Y	ATN1_uc001qrx.1_Missense_Mutation_p.S1016Y	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	1016					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCTGACATGTCCTATGCTGAG	0.667													23	78					7.92952e-12	1.42408e-11	1	0	A	7048173	A	A	7048173	3	1	138	1	0	0	0	0	1	0	0	0	1113	855	30	2	3069	2	ATN1	12	7048173	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	1363152	7048173	126803722	129	24876											
EMG1	10436	broad.mit.edu	37	chr12	7080212	7080213	+	Splice_Site	INS	-	C	C																															acaagatcggaggccgtagtINSttattgtggtgctggaaggg																								rs17857448		TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:7080212_7080213insC	uc001qsh.3	+	2	272	c.129_splice	c.e2+1	p.L43_splice	PHB2_uc001qsd.2_5'Flank|PHB2_uc010sft.1_5'Flank|PHB2_uc010sfu.1_5'Flank|EMG1_uc009zfo.2_RNA|EMG1_uc010sfv.1_RNA	NM_006331	NP_006322	Q92979	NEP1_HUMAN	ribosome biogenesis protein NEP1						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding				0						GAGGCCGTAGTTTATTGTGGTG	0.569													---	---	---								C	7080213	C	C	7080212	8	5	138	1	0	1	1	0	0	0	1	0	5114	1722	60	0	128	0	EMG1	12	7080212	Splice_Site	INS	-	TCGA-CR-7367-01A-11D-2012-08	32039	7080212	126771683	130	24877											
CD69	969	broad.mit.edu	37	chr12	9907188	9907188	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttctggagacttaccagttGttaaattctttgccatttga	9	17	7	8	0	2	2	0	1	2	1	2	3	2	2	2	1	2	2	2	1	3	7			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:9907188G>T	uc001qwk.2	-	4	567	c.486C>A	c.(484-486)AAC>AAA	p.N162K	CD69_uc010sgu.1_Missense_Mutation_p.N162K|CD69_uc010sgv.1_3'UTR	NM_001781	NP_001772	Q07108	CD69_HUMAN	CD69 molecule	162	C-type lectin.|Extracellular (Potential).					integral to plasma membrane	sugar binding|transmembrane receptor activity				0						CTTACCAGTTGTTAAATTCTT	0.413													38	123					9.80977e-26	1.89727e-25	1	0	T	9907188	T	T	9907188	3	4	138	1	0	0	0	0	1	0	0	0	3046	1368	48	4	121	4	CD69	12	9907188	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	2826976	9907188	123944707	131	24878											
CAPRIN2	65981	broad.mit.edu	37	chr12	30877333	30877333	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacctggagtagctgaaggcGgttgtgacgttggaattgca	9	11	15	6	2	0	2	0	2	0	0	0	4	0	4	1	4	3	5	1	4	4	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:30877333G>T	uc001rji.1	-	10	2709	c.1958C>A	c.(1957-1959)CCG>CAG	p.P653Q	CAPRIN2_uc001rjf.1_Missense_Mutation_p.P450Q|CAPRIN2_uc001rjg.1_Missense_Mutation_p.P320Q|CAPRIN2_uc001rjh.1_Missense_Mutation_p.P653Q|CAPRIN2_uc001rjj.1_Missense_Mutation_p.P320Q|CAPRIN2_uc001rjk.3_Missense_Mutation_p.P653Q|CAPRIN2_uc001rjl.3_Missense_Mutation_p.P653Q|CAPRIN2_uc001rjm.1_Missense_Mutation_p.P320Q	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	653					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AGCTGAAGGCGGTTGTGACGT	0.388													4	26					0.000602214	0.000972383	1	0	T	30877333	T	T	30877333	3	4	138	1	0	0	0	0	1	0	0	0	2648	1116	39	3	1461	3	CAPRIN2	12	30877333	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	20970145	30877333	102974562	132	24879											
ADAMTS20	80070	broad.mit.edu	37	chr12	43822059	43822059	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttactgatccccatggtccGgttctccactggtttcctct	4	15	7	15	1	2	1	0	1	2	0	6	1	5	1	5	3	1	2	5	3	1	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:43822059G>A	uc010skx.1	-	26	3930	c.3930C>T	c.(3928-3930)ACC>ACT	p.T1310T	ADAMTS20_uc001rno.1_Silent_p.T428T|ADAMTS20_uc001rnp.1_Silent_p.T464T	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1310	TSP type-1 9.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCCATGGTCCGGTTCTCCACT	0.358													10	92					0	0	0	0	A	43822059	A	A	43822059	2	1	138	1	0	0	0	0	0	0	0	1	266	1103	39	1		1	ADAMTS20	12	43822059	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	12944726	43822059	90029836	133	24880											
ITGB7	3695	broad.mit.edu	37	chr12	53590515	53590515	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgaatggtgactggcagcGctccagccgggtggggcagg	6	6	19	10	2	0	2	0	2	0	0	1	2	1	2	2	6	2	4	2	6	1	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:53590515G>A	uc009zmv.2	-	5	735	c.664C>T	c.(664-666)CGC>TGC	p.R222C	ITGB7_uc001scc.2_Missense_Mutation_p.R222C|ITGB7_uc010snz.1_RNA|ITGB7_uc010soa.1_3'UTR	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	222	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						GACTGGCAGCGCTCCAGCCGG	0.617													8	15					0	0	0	0	A	53590515	A	A	53590515	3	1	138	1	0	0	0	0	1	0	0	0	7939	1087	38	1	1776	1	ITGB7	12	53590515	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	9768456	53590515	80261380	134	24881											
ESYT1	23344	broad.mit.edu	37	chr12	56528126	56528126	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccctcctctacatctccagGctgtctacagtaccaactgc	8	11	5	17	0	3	0	0	0	3	0	6	0	5	0	4	1	5	2	4	1	4	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:56528126G>A	uc001sjq.2	+	15	1596	c.1546G>A	c.(1546-1548)GCT>ACT	p.A516T	ESYT1_uc001sjr.2_Missense_Mutation_p.A526T	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	516	C2 2.					integral to membrane		p.A516G(1)		ovary(4)|skin(1)	5						ACATCTCCAGGCTGTCTACAG	0.502													35	104					0	0	0	0	A	56528126	A	A	56528126	3	1	138	1	0	0	0	0	1	0	0	0	5288	1217	42	4	1634	4	ESYT1	12	56528126	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	2937611	56528126	77323769	135	24882											
LRP1	4035	broad.mit.edu	37	chr12	57604546	57604546	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggcttcacgggccccaaatGcacccagcaggtgtgtgcgg	7	6	15	13	2	1	0	1	0	0	0	1	0	1	0	3	4	3	3	3	4	1	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:57604546G>A	uc001snd.2	+	83	13266	c.12800G>A	c.(12799-12801)TGC>TAC	p.C4267Y		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4267	EGF-like 18.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGCCCCAAATGCACCCAGCAG	0.667													14	90					0	0	0	0	A	57604546	A	A	57604546	3	1	138	1	0	0	0	0	1	0	0	0	9001	1319	46	4	13130	4	LRP1	12	57604546	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	1076420	57604546	76247349	136	24883											
TMBIM4	51643	broad.mit.edu	37	chr12	66531827	66531827	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggctgatggcagctaatacGtactcttcaggtgacagttt	10	12	11	8	1	2	2	1	2	1	0	2	2	2	2	0	3	3	5	0	3	3	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:66531827G>A	uc001stc.2	-	7	706	c.630C>T	c.(628-630)TAC>TAT	p.Y210Y	LLPH_uc010ssx.1_RNA|TMBIM4_uc001std.2_Silent_p.Y179Y|TMBIM4_uc009zqr.2_Silent_p.Y257Y|TMBIM4_uc001ste.2_RNA|TMBIM4_uc001stf.2_3'UTR|TMBIM4_uc009zqs.2_3'UTR	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	210	Helical; (Potential).					integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)		CAGCTAATACGTACTCTTCAG	0.413													25	47					0	0	0	0	A	66531827	A	A	66531827	2	1	138	1	0	0	0	0	0	0	0	1	16048	1140	40	1		1	TMBIM4	12	66531827	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	8927281	66531827	67320068	137	24884											
C12orf63	374467	broad.mit.edu	37	chr12	97043804	97043804	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccgaggagcaaatttgtgtgTaatggatcattttatgaaaa	14	13	10	4	1	1	1	1	1	0	0	1	4	1	3	1	2	1	2	1	2	5	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:97043804T>C	uc001tet.1	+	2	179	c.101T>C	c.(100-102)GTA>GCA	p.V34A		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	34										skin(6)|ovary(1)	7						AATTTGTGTGTAATGGATCAT	0.308													10	52					0	0	0	0	C	97043804	C	C	97043804	3	2	138	1	0	0	0	0	1	0	0	0	1712	1638	57	5	103	5	C12orf63	12	97043804	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	30511977	97043804	36808091	138	24885											
ACAD10	80724	broad.mit.edu	37	chr12	112150407	112150407	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgaaaaagacgatggaaattCcgaaagattccttgcagaag	17	8	10	6	2	0	4	0	1	0	3	2	7	2	5	2	1	1	1	2	1	5	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:112150407C>T	uc001tsq.2	+	6	996	c.796C>T	c.(796-798)CCG>TCG	p.P266S	ACAD10_uc001tso.3_Missense_Mutation_p.P266S|ACAD10_uc001tsp.2_Missense_Mutation_p.P266S|ACAD10_uc009zvx.2_Missense_Mutation_p.P297S|ACAD10_uc001tsr.2_Missense_Mutation_p.P4S|ACAD10_uc001tss.1_5'Flank	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	266							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						GATGGAAATTCCGAAAGATTC	0.453													30	197					0	0	0	0	T	112150407	T	T	112150407	3	4	138	1	0	0	0	0	1	0	0	0	108	855	30	2	911	2	ACAD10	12	112150407	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	15106603	112150407	21701488	139	24886											
VSIG10	54621	broad.mit.edu	37	chr12	118517157	118517157	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaaacagactcactgatctGcaccatgcagctggcgcccg	11	6	9	15	2	2	2	1	1	1	1	2	2	2	2	2	1	4	3	2	1	2	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:118517157G>T	uc001tws.2	-	4	1253	c.919C>A	c.(919-921)CAG>AAG	p.Q307K		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	307	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane					0						TCACTGATCTGCACCATGCAG	0.517													6	64					2.0095e-06	3.38442e-06	1	0	T	118517157	T	T	118517157	3	4	138	1	0	0	0	0	1	0	0	0	17291	1328	46	4	727	4	VSIG10	12	118517157	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	6366750	118517157	15334738	140	24887											
DHX37	57647	broad.mit.edu	37	chr12	125470690	125470690	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttctgcagcactttcttCtccttcttggtcagaggctt	5	18	7	11	0	5	1	1	0	4	1	6	1	5	1	1	2	2	3	1	2	0	7			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:125470690C>T	uc001ugy.2	-	2	327	c.228G>A	c.(226-228)GAG>GAA	p.E76E		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	76							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		GCACTTTCTTCTCCTTCTTGG	0.512													77	114					0	0	0	0	T	125470690	T	T	125470690	2	4	138	1	0	0	0	0	0	0	0	1	4532	912	32	2		2	DHX37	12	125470690	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	6953533	125470690	8381205	141	24888											
CDK8	1024	broad.mit.edu	37	chr13	26971342	26971342	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaacataaagttaaaccaGatagtaaagcattccacttg	20	9	5	7	0	0	1	0	0	0	1	1	1	1	1	2	0	3	3	2	0	9	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:26971342G>A	uc001uqr.1	+	9	939	c.913G>A	c.(913-915)GAT>AAT	p.D305N	CDK8_uc001uqs.1_Missense_Mutation_p.D305N|CDK8_uc001uqt.1_Missense_Mutation_p.D132N	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	305	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGTTAAACCAGATAGTAAAGC	0.318													10	32					0	0	0	0	A	26971342	A	A	26971342	3	1	138	1	0	0	0	0	1	0	0	0	3165	942	33	2	947	2	CDK8	13	26971342	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08		26971342	88198536	142	24889											
DGKH	160851	broad.mit.edu	37	chr13	42803280	42803280	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atgtgaagcgaattctccagGgaattaaagagcttggaagg	14	9	13	5	1	1	2	0	1	1	1	2	5	1	4	1	3	2	1	1	3	6	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:42803280G>A	uc001uyl.1	+	30	3640	c.3619G>A	c.(3619-3621)GGA>AGA	p.G1207R	DGKH_uc010tfh.1_Missense_Mutation_p.G1163E|DGKH_uc001uym.1_Missense_Mutation_p.G1163E|DGKH_uc010tfi.1_Missense_Mutation_p.G918E|DGKH_uc010tfj.1_Missense_Mutation_p.G1062R|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.G1078R|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	1207	SAM.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		AATTCTCCAGGGAATTAAAGA	0.323													14	82					0	0	0	0	A	42803280	A	A	42803280	3	1	138	1	0	0	0	0	1	0	0	0	4492	1233	43	4	3737	4	DGKH	13	42803280	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	15831938	42803280	72366598	143	24890											
CLN5	1203	broad.mit.edu	37	chr13	77566263	77566263	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtagacacggcacagggCgccgagatgcggcggggcgc	8	2	20	11	6	0	2	0	0	0	2	0	4	0	2	1	6	1	2	1	6	1	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:77566263C>T	uc001vkc.2	+	1	205	c.177C>T	c.(175-177)GGC>GGT	p.G59G		NM_006493	NP_006484	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	10					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		CGGCACAGGGCGCCGAGATgc	0.642													7	23					0	0	0	0	T	77566263	T	T	77566263	2	4	138	1	0	0	0	0	0	0	0	1	3559	755	27	1		1	CLN5	13	77566263	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	34762983	77566263	37603615	144	24891											
EDNRB	1910	broad.mit.edu	37	chr13	78477688	78477688	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccacagaggctttctgtaTgaaaggcaccagcttacaca	12	9	8	12	0	1	2	0	1	1	1	2	2	2	2	2	2	2	4	2	2	3	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:78477688T>C	uc001vko.2	-	2	796	c.538A>G	c.(538-540)ATA>GTA	p.I180V	EDNRB_uc001vkq.1_Missense_Mutation_p.I180V|uc001vkn.1_Intron|EDNRB_uc010aez.1_Missense_Mutation_p.I180V|EDNRB_uc001vkp.1_Missense_Mutation_p.I263V	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	180	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GCTTTCTGTATGAAAGGCACC	0.443													33	53					0	0	0	0	C	78477688	C	C	78477688	3	2	138	1	0	0	0	0	1	0	0	0	4942	1464	51	5	935	5	EDNRB	13	78477688	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	911425	78477688	36692190	145	24892											
SLITRK1	114798	broad.mit.edu	37	chr13	84453689	84453689	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcggaggagttggcatctcGtctcttggaccgctttcggt	4	12	14	11	5	2	0	0	0	2	0	5	3	2	3	1	5	0	3	1	5	0	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:84453689G>A	uc001vlk.2	-	1	2840	c.1954C>T	c.(1954-1956)CGA>TGA	p.R652*		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	652	Cytoplasmic (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TTGGCATCTCGTCTCTTGGAC	0.572													13	47					0	0	0	0	A	84453689	A	A	84453689	4	1	138	1	0	0	0	0	0	1	0	0	14806	1153	40	1	140	1	SLITRK1	13	84453689	Nonsense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	5976001	84453689	30716189	146	24893											
ERCC5	2073	broad.mit.edu	37	chr13	103518238	103518238	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatgcggaagattcgctcCatgaatggcaagatattaat	15	10	10	6	2	0	4	0	1	0	3	2	5	1	5	1	2	1	2	1	2	6	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:103518238C>T	uc001vpw.2	+	9	2619	c.2176C>T	c.(2176-2178)CAT>TAT	p.H726Y	ERCC5_uc001vpu.1_Missense_Mutation_p.H1180Y|ERCC5_uc010tjb.1_Missense_Mutation_p.H726Y|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.H558Y	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	726					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AGATTCGCTCCATGAATGGCA	0.483			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				9	48					0	0	0	0	T	103518238	T	T	103518238	3	4	138	1	0	0	0	0	1	0	0	0	5240	594	21	4	2210	4	ERCC5	13	103518238	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	19064549	103518238	11651640	147	24894											
FAM155A	728215	broad.mit.edu	37	chr13	108518140	108518140	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcatggtggtcatagtcctGgtaagcctcgacgcactgcc	8	9	12	12	2	1	0	1	0	0	0	3	1	2	0	3	3	3	3	3	3	2	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:108518140G>T	uc001vql.2	-	1	1321	c.805C>A	c.(805-807)CAG>AAG	p.Q269K		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	269						integral to membrane	binding			skin(1)	1						TCATAGTCCTGGTAAGCCTCG	0.522													22	119					2.52088e-20	4.82255e-20	1	0	T	108518140	T	T	108518140	3	4	138	1	0	0	0	0	1	0	0	0	5493	1357	47	4	583	4	FAM155A	13	108518140	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	4999902	108518140	6651738	148	24895											
CMA1	1215	broad.mit.edu	37	chr14	24974805	24974805	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggggctttgcatccgaccGtccataggatacgatgccct	8	9	12	12	3	0	0	0	0	0	0	2	3	2	1	4	3	3	2	4	3	2	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr14:24974805G>A	uc001wpp.1	-	5	691	c.661C>T	c.(661-663)CGG>TGG	p.R221W	CMA1_uc010alx.1_Missense_Mutation_p.R110W	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	221	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		GCATCCGACCGTCCATAGGAT	0.592													9	62					0	0	0	0	A	24974805	A	A	24974805	3	1	138	1	0	0	0	0	1	0	0	0	3589	1144	40	1	86	1	CMA1	14	24974805	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08		24974805	82374735	149	24896											
SYNE2	23224	broad.mit.edu	37	chr14	64496701	64496701	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatactacattggacaattTctccaaggaatttgtcagtt	13	14	7	7	0	2	0	1	0	1	0	3	3	2	2	1	2	2	1	1	2	6	6			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr14:64496701T>C	uc001xgm.2	+	44	7033	c.6803T>C	c.(6802-6804)TTC>TCC	p.F2268S	SYNE2_uc001xgl.2_Missense_Mutation_p.F2268S	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2268	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTGGACAATTTCTCCAAGGAA	0.408													3	35					0	0	0	0	C	64496701	C	C	64496701	3	2	138	1	0	0	0	0	1	0	0	0	15512	1783	62	5	6973	5	SYNE2	14	64496701	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	39521896	64496701	42852839	150	24897											
TLN2	83660	broad.mit.edu	37	chr15	62939593	62939593	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaccatctacagctgtgtaCgatgcgtgtcgagtcattcg	9	11	11	10	4	2	0	1	0	1	0	4	3	2	0	1	0	5	2	1	0	3	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr15:62939593C>G	uc002alb.3	+	1	84	c.84C>G	c.(82-84)TAC>TAG	p.Y28*	MGC15885_uc010uib.1_5'Flank|MGC15885_uc002ala.3_5'Flank	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	28					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CAGCTGTGTACGATGCGTGTC	0.488													19	119					0	0	0	0	G	62939593	G	G	62939593	4	3	138	1	0	0	0	0	0	1	0	0	16014	547	19	3	86	3	TLN2	15	62939593	Nonsense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08		62939593	39591799	151	24898											
SOLH	6650	broad.mit.edu	37	chr16	596993	596993	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagaaatggccctgcgcccGctgcaccttccgcaacttcc	7	7	9	18	3	0	1	0	0	0	1	2	1	2	1	5	1	3	4	5	1	2	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:596993G>A	uc002chi.2	+	4	518	c.155G>A	c.(154-156)CGC>CAC	p.R52H	SOLH_uc002chh.1_Missense_Mutation_p.R52H	NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	52	RanBP2-type 2.				proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				CCCTGCGCCCGCTGCACCTTC	0.692													5	40					0	0	0	0	A	596993	A	A	596993	3	1	138	1	0	0	0	0	1	0	0	0	14989	1087	38	1	157	1	SOLH	16	596993	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08		596993	89757760	152	24899											
ATP6V0C	527	broad.mit.edu	37	chr16	2569563	2569563	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttcctccagctgggcgcCggcctgagcgtgggcctgag	4	7	16	14	3	0	2	0	2	0	0	2	2	2	2	5	3	3	2	5	3	0	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:2569563C>T	uc002cqn.2	+	3	437	c.285C>T	c.(283-285)GCC>GCT	p.A95A	TBC1D24_uc002cqm.2_3'UTR|ATP6V0C_uc002cqo.2_Silent_p.A52A|AMDHD2_uc002cqp.2_5'Flank|AMDHD2_uc002cqq.2_5'Flank|AMDHD2_uc010uwc.1_5'Flank|AMDHD2_uc010uwd.1_5'Flank	NM_001694	NP_001685	P27449	VATL_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	95	Helical; (Potential).				ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|interspecies interaction between organisms|transferrin transport	endosome membrane|integral to membrane|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|ubiquitin protein ligase binding			ovary(1)	1		Ovarian(90;0.17)				AGCTGGGCGCCGGCCTGAGCG	0.701													19	39					0	0	0	0	T	2569563	T	T	2569563	2	4	138	1	0	0	0	0	0	0	0	1	1174	639	23	1		1	ATP6V0C	16	2569563	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	1972570	2569563	87785190	153	24900											
TXNDC11	51061	broad.mit.edu	37	chr16	11792153	11792153	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttacagatgttctcagctGtgtagttcaggacctccctg	8	13	9	11	0	2	1	2	0	1	1	4	2	3	2	2	1	2	4	2	1	2	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:11792153G>A	uc010buu.1	-	8	1078	c.1016C>T	c.(1015-1017)ACA>ATA	p.T339I	TXNDC11_uc002dbg.1_Missense_Mutation_p.T312I	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	339					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						GTTCTCAGCTGTGTAGTTCAG	0.552													12	34					0	0	0	0	A	11792153	A	A	11792153	3	1	138	1	0	0	0	0	1	0	0	0	16860	1377	48	4	1965	4	TXNDC11	16	11792153	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	9222590	11792153	78562600	154	24901											
PDXDC1	23042	broad.mit.edu	37	chr16	15127244	15127244	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccacagcccgggagatagaGgagaactcgagggtccgtag	11	4	16	10	3	0	3	0	0	0	3	2	6	1	3	3	3	2	1	3	3	3	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:15127244G>A	uc002dda.3	+	19	2024	c.1800G>A	c.(1798-1800)GAG>GAA	p.E600E	PDXDC1_uc010uzl.1_Silent_p.E585E|PDXDC1_uc010uzm.1_Silent_p.E509E|PDXDC1_uc002ddb.3_Silent_p.E573E|PDXDC1_uc010uzn.1_Silent_p.E572E|PDXDC1_uc002ddc.2_Intron	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	600					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GGGAGATAGAGGAGAACTCGA	0.567													33	101					0	0	0	0	A	15127244	A	A	15127244	2	1	138	1	0	0	0	0	0	0	0	1	11750	991	35	4		4	PDXDC1	16	15127244	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	3335091	15127244	75227509	155	24902											
ACSM2A	123876	broad.mit.edu	37	chr16	20486734	20486734	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atgggtgcccccattgtttaCcggatgttgctacagcagga	8	11	12	10	1	0	0	0	0	0	0	0	2	0	2	3	3	5	4	3	3	2	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:20486734C>T	uc010bwe.2	+	8	1184	c.945C>T	c.(943-945)TAC>TAT	p.Y315Y	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Silent_p.Y236Y|ACSM2A_uc002dhf.3_Silent_p.Y315Y|ACSM2A_uc002dhg.3_Silent_p.Y315Y|ACSM2A_uc010vay.1_Silent_p.Y236Y|ACSM2A_uc002dhh.3_5'Flank	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	315					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CCATTGTTTACCGGATGTTGC	0.512													26	104					0	0	0	0	T	20486734	T	T	20486734	2	4	138	1	0	0	0	0	0	0	0	1	183	518	18	4		4	ACSM2A	16	20486734	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	5359490	20486734	69868019	156	24903											
GTF3C1	2975	broad.mit.edu	37	chr16	27549582	27549582	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttccaggatgcagtaggagAagtcgggcagcttcaggtcg	9	8	16	8	2	1	1	1	0	0	1	4	3	2	2	1	4	2	5	1	4	2	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:27549582A>T	uc002dov.1	-	3	567	c.527T>A	c.(526-528)TTC>TAC	p.F176Y	GTF3C1_uc002dou.2_Missense_Mutation_p.F176Y	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	176						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GCAGTAGGAGAAGTCGGGCAG	0.602													16	93					0	0	0	0	T	27549582	T	T	27549582	3	4	138	1	0	0	0	0	1	0	0	0	6911	246	9	5	5942	5	GTF3C1	16	27549582	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	7062848	27549582	62805171	157	24904											
DOC2A	8448	broad.mit.edu	37	chr16	30018259	30018259	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcccctgcccctgctccGcctgctccaactgcggggca	4	6	11	20	2	0	0	0	0	0	0	2	0	2	0	7	2	6	4	7	2	1	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:30018259G>A	uc002dvm.2	-	8	825	c.725C>T	c.(724-726)GCG>GTG	p.A242V	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|DOC2A_uc002dvl.2_Missense_Mutation_p.A240V|DOC2A_uc002dvn.2_Missense_Mutation_p.A242V|DOC2A_uc010vef.1_RNA|DOC2A_uc002dvo.2_Missense_Mutation_p.A242V|DOC2A_uc002dvp.2_Missense_Mutation_p.A242V|DOC2A_uc002dvq.2_Missense_Mutation_p.A242V	NM_003586	NP_003577	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	242	Interaction with UNC13D.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			ovary(2)	2						CCCCTGCTCCGCCTGCTCCAA	0.682													8	22					0	0	0	0	A	30018259	A	A	30018259	3	1	138	1	0	0	0	0	1	0	0	0	4705	1087	38	1	493	1	DOC2A	16	30018259	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	2468677	30018259	60336494	158	24905											
SETD1A	9739	broad.mit.edu	37	chr16	30995053	30995053	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caccatcatcgatgccaccaAgtgtggcaacctggccagat	11	7	9	14	1	1	1	1	0	0	1	2	2	1	1	5	2	2	1	5	2	2	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:30995053A>C	uc002ead.1	+	18	5596	c.4910A>C	c.(4909-4911)AAG>ACG	p.K1637T	HSD3B7_uc002eaf.2_5'Flank|HSD3B7_uc010cac.2_5'Flank|HSD3B7_uc002eag.2_5'Flank|HSD3B7_uc002eah.2_5'Flank	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1637	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						GATGCCACCAAGTGTGGCAAC	0.652													10	37					0	0	0	0	C	30995053	C	C	30995053	3	2	138	1	0	0	0	0	1	0	0	0	14195	72	3	5	4976	5	SETD1A	16	30995053	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	976794	30995053	59359700	159	24906											
N4BP1	9683	broad.mit.edu	37	chr16	48580115	48580115	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggtccacttcttcccagaGgatcatcgggaaccataaat	12	9	9	11	1	2	1	1	0	1	1	5	4	4	3	3	3	1	0	3	3	3	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:48580115G>T	uc002efp.2	-	6	2513	c.2276C>A	c.(2275-2277)CCT>CAT	p.P759H		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	759					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				TCTTCCCAGAGGATCATCGGG	0.458													20	75					2.89027e-11	5.11243e-11	1	0	T	48580115	T	T	48580115	3	4	138	1	0	0	0	0	1	0	0	0	10162	1000	35	4	422	4	N4BP1	16	48580115	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	17585062	48580115	41774638	160	24907											
SETD6	79918	broad.mit.edu	37	chr16	58552440	58552440	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagaggagctgaccaccaCactaaaggtaaacggctgaa	16	5	11	9	1	0	4	0	3	0	1	0	5	0	5	2	3	2	3	2	3	6	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:58552440C>T	uc002ens.2	+	7	1168	c.1109C>T	c.(1108-1110)ACA>ATA	p.T370I	SETD6_uc002enr.2_Missense_Mutation_p.T346I|SETD6_uc010cdm.2_RNA	NM_001160305	NP_001153777	Q8TBK2	SETD6_HUMAN	SET domain containing 6 isoform a	370					negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			ovary(1)	1						CTGACCACCACACTAAAGGTA	0.443													8	55					0	0	0	0	T	58552440	T	T	58552440	3	4	138	1	0	0	0	0	1	0	0	0	14200	478	17	4	1135	4	SETD6	16	58552440	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	9972325	58552440	31802313	161	24908											
CNTROB	116840	broad.mit.edu	37	chr17	7847811	7847811	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagactggcccgggagcaagCgcgagtgtgcgaactgcaga	10	4	16	11	4	0	2	0	0	0	2	0	5	0	3	1	2	5	2	1	2	2	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:7847811C>T	uc002gjq.2	+	13	2508	c.1589C>T	c.(1588-1590)GCG>GTG	p.A530V	CNTROB_uc002gjp.2_Missense_Mutation_p.A530V|CNTROB_uc002gjr.2_Missense_Mutation_p.A432V|CNTROB_uc010vum.1_3'UTR	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	530	Potential.|Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				CGGGAGCAAGCGCGAGTGTGC	0.567													5	30					0	0	0	0	T	7847811	T	T	7847811	3	4	138	1	0	0	0	0	1	0	0	0	3666	768	27	1	1635	1	CNTROB	17	7847811	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08		7847811	73347399	162	24909											
ACCN1	40	broad.mit.edu	37	chr17	32483155	32483155	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccgcagggcctccagcaCggaggggtcagccagatggg	7	4	17	13	2	1	1	1	0	0	1	2	2	2	2	4	5	3	2	4	5	0	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:32483155C>T	uc002hhu.2	-	1	671	c.397G>A	c.(397-399)GTG>ATG	p.V133M		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	133	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	GCCTCCAGCACGGAGGGGTCA	0.612													14	97					0	0	0	0	T	32483155	T	T	32483155	3	4	138	1	0	0	0	0	1	0	0	0	128	536	19	1	1893	1	ACCN1	17	32483155	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	24635344	32483155	48712055	163	24910											
SLFN5	162394	broad.mit.edu	37	chr17	33592632	33592633	+	Frame_Shift_Ins	INS	-	A	A																															caccaaagcaagtgaagtggINSaaaaatataaagacaggctt																										TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:33592632_33592633insA	uc002hjf.3	+	5	2518_2519	c.2401_2402insA	c.(2401-2403)GAAfs	p.E801fs	SLFN5_uc010wcg.1_3'UTR	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	801					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		AAGTGAAGTGGAAAAATATAAA	0.426													---	---	---								A	33592633	A	A	33592632	7	5	138	1	0	1	1	0	0	0	0	0	14801	1175	41	0	2415	0	SLFN5	17	33592632	Frame_Shift_Ins	INS	-	TCGA-CR-7367-01A-11D-2012-08	1109477	33592632	47602578	164	24911											
VAT1	10493	broad.mit.edu	37	chr17	41168533	41168533	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggccagggccatcaggtTccgtttggggcccgtcagca	5	7	15	14	3	2	0	2	0	0	0	3	0	3	0	5	5	1	3	5	5	0	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:41168533T>C	uc002icm.1	-	5	1009	c.889A>G	c.(889-891)AAC>GAC	p.N297D	VAT1_uc010cyw.1_Missense_Mutation_p.N163D|VAT1_uc010whk.1_Missense_Mutation_p.N229D	NM_006373	NP_006364	Q99536	VAT1_HUMAN	vesicle amine transport protein 1	297						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		GCCATCAGGTTCCGTTTGGGG	0.612													3	25					0	0	0	0	C	41168533	C	C	41168533	3	2	138	1	0	0	0	0	1	0	0	0	17197	1783	62	5	300	5	VAT1	17	41168533	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	7575901	41168533	40026677	165	24912											
NSF	4905	broad.mit.edu	37	chr17	44770322	44770322	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgatgaaattgatgccatCtgcaagcagagagggagcat	13	10	12	6	0	1	4	0	3	1	1	1	6	1	5	1	1	4	3	1	1	2	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:44770322C>T	uc002iku.2	+	10	1103	c.999C>T	c.(997-999)ATC>ATT	p.I333I	NSF_uc010wke.1_Silent_p.I239I|NSF_uc010wkf.1_Silent_p.I239I|NSF_uc010wkg.1_Silent_p.I328I	NM_006178	NP_006169	P46459	NSF_HUMAN	vesicle-fusing ATPase	333					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			ovary(1)	1		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		TTGATGCCATCTGCAAGCAGA	0.418													4	28					0	0	0	0	T	44770322	T	T	44770322	2	4	138	1	0	0	0	0	0	0	0	1	10725	903	32	2		2	NSF	17	44770322	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	3601789	44770322	36424888	166	24913											
COL1A1	1277	broad.mit.edu	37	chr17	48263006	48263006	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgccccaggctccggtgtGactctggggtggggcggaga	4	8	18	11	2	1	2	0	1	1	1	2	3	2	2	3	7	1	1	3	7	0	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:48263006G>A	uc002iqm.2	-	51	4378	c.4252C>T	c.(4252-4254)CAC>TAC	p.H1418Y		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	1418	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	GCTCCGGTGTGACTCTGGGGT	0.617			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						8	40					0	0	0	0	A	48263006	A	A	48263006	3	1	138	1	0	0	0	0	1	0	0	0	3692	1290	45	2	146	2	COL1A1	17	48263006	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	3492684	48263006	32932204	167	24914											
RPS6KB1	6198	broad.mit.edu	37	chr17	58009058	58009058	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctacagagacctgaagccGgagaatatcatgcttaatca	15	9	8	9	1	3	3	2	1	1	2	3	5	3	3	2	1	3	1	2	1	5	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:58009058G>A	uc002ixy.2	+	7	766	c.663G>A	c.(661-663)CCG>CCA	p.P221P	RPS6KB1_uc010ddj.1_Silent_p.P221P|RPS6KB1_uc010wom.1_Silent_p.P168P|RPS6KB1_uc010won.1_Silent_p.P198P|RPS6KB1_uc010woo.1_Silent_p.P156P	NM_003161	NP_003152	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide	221	Protein kinase.				apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			large_intestine(1)	1	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			ACCTGAAGCCGGAGAATATCA	0.388													7	38					0	0	0	0	A	58009058	A	A	58009058	2	1	138	1	0	0	0	0	0	0	0	1	13721	1103	39	1		1	RPS6KB1	17	58009058	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	9746052	58009058	23186152	168	24915											
SMURF2	64750	broad.mit.edu	37	chr17	62589665	62589665	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtgattccatacactgatcGtaactgaatcagactttcca	12	13	6	10	1	1	4	1	3	0	1	4	4	3	4	2	0	2	1	2	0	3	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:62589665G>A	uc002jep.1	-	4	615	c.227C>T	c.(226-228)ACG>ATG	p.T76M	SMURF2_uc002jeq.1_Translation_Start_Site|SMURF2_uc002jer.1_Translation_Start_Site	NM_022739	NP_073576	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	76	C2.				BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			TACACTGATCGTAACTGAATC	0.393													6	64					0	0	0	0	A	62589665	A	A	62589665	3	1	138	1	0	0	0	0	1	0	0	0	14884	1145	40	1	2083	1	SMURF2	17	62589665	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	4580607	62589665	18605545	169	24916											
ARSG	22901	broad.mit.edu	37	chr17	66381312	66381312	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaccagcactgccttgttaAggtatgagaccaaaactacc	13	9	7	12	0	1	1	1	1	0	1	1	2	1	1	4	1	4	3	4	1	5	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:66381312A>T	uc002jhc.2	+	9	1886	c.1090A>T	c.(1090-1092)AGC>TGC	p.S364C	ARSG_uc002jhb.1_Missense_Mutation_p.S200C	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	364					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGCCTTGTTAAGGTATGAGAC	0.418													24	49					0	0	0	0	T	66381312	T	T	66381312	3	4	138	1	0	0	0	0	1	0	0	0	994	86	3	5	1120	5	ARSG	17	66381312	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	3791647	66381312	14813898	170	24917											
PIK3C3	5289	broad.mit.edu	37	chr18	39534966	39534967	+	5'Flank	INS	-	A	A																															gatagcgtctctttttctttINSaaaaaaaaaaaaaagtgctg																								rs139494080		TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:39534966_39534967insA	uc002lap.2	+						PIK3C3_uc010xcl.1_5'Flank|PIK3C3_uc002lao.2_5'Flank	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3						cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						TCTTTTTCTTTAAAAAAAAAAA	0.381										TSP Lung(28;0.18)			---	---	---								A	39534967	A	A	39534966	6	5	138	0	1	1	1	0	0	0	0	0	11967	1769	61	0		0	PIK3C3	18	39534966	5'Flank	INS	-	TCGA-CR-7367-01A-11D-2012-08		39534966	38542282	171	24918											
SYT4	6860	broad.mit.edu	37	chr18	40854093	40854093	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgggaaaattgccattgaGatctctcttttcaagatcca	11	15	7	8	0	3	2	1	1	2	2	5	4	4	3	2	1	1	0	2	1	3	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:40854093G>T	uc002law.2	-	2	670	c.301C>A	c.(301-303)CTC>ATC	p.L101I	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Missense_Mutation_p.L83I|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	101	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TTGCCATTGAGATCTCTCTTT	0.398													12	90					1.36491e-13	2.47654e-13	1	0	T	40854093	T	T	40854093	3	4	138	1	0	0	0	0	1	0	0	0	15542	942	33	2	988	2	SYT4	18	40854093	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	1319127	40854093	37223155	172	24919											
ST8SIA5	29906	broad.mit.edu	37	chr18	44260231	44260231	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgcagtgaccagaatgaggCcggtgctgatgcgcttggcg	7	7	16	11	4	0	4	0	3	0	1	0	4	0	4	3	3	2	3	3	3	1	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:44260231C>T	uc002lcj.1	-	7	1473	c.905G>A	c.(904-906)GGC>GAC	p.G302D	ST8SIA5_uc002lci.1_Missense_Mutation_p.G149D|ST8SIA5_uc010xcy.1_Missense_Mutation_p.G338D|ST8SIA5_uc010xcz.1_Missense_Mutation_p.G271D	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	302	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						CAGAATGAGGCCGGTGCTGAT	0.622													15	75					0	0	0	0	T	44260231	T	T	44260231	3	4	138	1	0	0	0	0	1	0	0	0	15301	739	26	4	229	4	ST8SIA5	18	44260231	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	3406138	44260231	33817017	173	24920											
CDH7	1005	broad.mit.edu	37	chr18	63511243	63511243	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcggaagctacccaggttGggaatatcattggcactgta	10	11	12	8	1	1	0	1	0	0	0	2	2	1	2	1	4	2	4	1	4	5	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:63511243G>A	uc002ljz.2	+	7	1502	c.1177G>A	c.(1177-1179)GGG>AGG	p.G393R	CDH7_uc002lka.2_Missense_Mutation_p.G393R|CDH7_uc002lkb.2_Missense_Mutation_p.G393R	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	393	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TACCCAGGTTGGGAATATCAT	0.448													41	75					0	0	0	0	A	63511243	A	A	63511243	3	1	138	1	0	0	0	0	1	0	0	0	3130	1348	47	4	1199	4	CDH7	18	63511243	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	19251012	63511243	14566005	174	24921											
TSHZ1	10194	broad.mit.edu	37	chr18	72999914	72999914	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaaacctcacaggccgccTgacgcccaagtcctccacgc	11	4	8	18	3	1	1	1	1	0	0	3	2	3	1	6	1	1	0	6	1	3	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:72999914T>A	uc002lly.2	+	2	2980	c.2417T>A	c.(2416-2418)CTG>CAG	p.L806Q		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	851						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		ACAGGCCGCCTGACGCCCAAG	0.602													9	79					0	0	0	0	A	72999914	A	A	72999914	3	1	138	1	0	0	0	0	1	0	0	0	16690	1580	55	5	2419	5	TSHZ1	18	72999914	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	9488671	72999914	5077334	175	24922											
SALL3	27164	broad.mit.edu	37	chr18	76757094	76757094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcactaacgggctcgccatGaagaacaacgagatctccgt	13	7	9	12	4	2	3	1	1	1	2	4	4	2	3	2	1	3	1	2	1	4	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:76757094G>A	uc002lmt.2	+	3	3675	c.3675G>A	c.(3673-3675)ATG>ATA	p.M1225I	SALL3_uc010dra.2_Missense_Mutation_p.M760I	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGCTCGCCATGAAGAACAACG	0.602													35	166					0	0	0	0	A	76757094	A	A	76757094	3	1	138	1	0	0	0	0	1	0	0	0	13877	1290	45	2	3685	2	SALL3	18	76757094	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	3757180	76757094	1320154	176	24923											
C3	718	broad.mit.edu	37	chr19	6714452	6714452	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttgaccgggatgccttcCgggttctgtgggaggcagga	5	10	17	9	2	1	1	0	1	1	0	2	4	2	4	3	5	2	3	3	5	0	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:6714452C>T	uc002mfm.2	-	5	572	c.510G>A	c.(508-510)CCG>CCA	p.P170P		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	170					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GGATGCCTTCCGGGTTCTGTG	0.562													5	43					0	0	0	0	T	6714452	T	T	6714452	2	4	138	1	0	0	0	0	0	0	0	1	2214	639	23	1		1	C3	19	6714452	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08		6714452	52414531	177	24924											
PDE4A	5141	broad.mit.edu	37	chr19	10570295	10570295	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggacctgctgaagaaattcCgcatccctgtggacacgatg	10	8	12	11	2	0	2	0	1	0	1	2	5	2	4	3	2	1	2	3	2	2	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:10570295C>T	uc002moj.2	+	10	1333	c.1225C>T	c.(1225-1227)CGC>TGC	p.R409C	PDE4A_uc002mok.2_Missense_Mutation_p.R383C|PDE4A_uc002mol.2_Missense_Mutation_p.R348C|PDE4A_uc002mom.2_Missense_Mutation_p.R170C|PDE4A_uc002mon.2_Intron|PDE4A_uc002moo.2_Missense_Mutation_p.R75C	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	409	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	GAAGAAATTCCGCATCCCTGT	0.637													6	39					0	0	0	0	T	10570295	T	T	10570295	3	4	138	1	0	0	0	0	1	0	0	0	11693	652	23	1	1720	1	PDE4A	19	10570295	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	3855843	10570295	48558688	178	24925											
SMARCA4	6597	broad.mit.edu	37	chr19	11101902	11101902	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caatgctaaggcctacaagcGcagcaagcgccagtccctgc	11	5	10	15	2	0	0	0	0	0	0	1	0	1	0	3	1	6	3	3	1	5	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:11101902G>A	uc002mqf.3	+	8	1606	c.1322G>A	c.(1321-1323)CGC>CAC	p.R441H	SMARCA4_uc010dxp.2_Missense_Mutation_p.R441H|SMARCA4_uc010dxo.2_Missense_Mutation_p.R441H|SMARCA4_uc002mqg.1_Missense_Mutation_p.R441H|SMARCA4_uc010dxq.2_Missense_Mutation_p.R441H|SMARCA4_uc010dxr.2_Missense_Mutation_p.R441H|SMARCA4_uc002mqj.3_Missense_Mutation_p.R441H|SMARCA4_uc010dxs.2_Missense_Mutation_p.R441H|SMARCA4_uc002mqe.2_Missense_Mutation_p.R441H	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	441					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCCTACAAGCGCAGCAAGCGC	0.632			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				4	38					0	0	0	0	A	11101902	A	A	11101902	3	1	138	1	0	0	0	0	1	0	0	0	14834	1087	38	1	1348	1	SMARCA4	19	11101902	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	531607	11101902	48027081	179	24926											
ZNF625	90589	broad.mit.edu	37	chr19	12256889	12256889	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccagtgtcagctctgtggtgCctattaagggatgcatgacc	8	11	12	10	0	2	1	1	1	1	0	2	2	2	2	3	2	3	2	3	2	2	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:12256889C>T	uc002mth.2	-	4	494	c.144G>A	c.(142-144)AGG>AGA	p.R48R	ZNF20_uc002mtg.1_Intron|ZNF625_uc010dyn.1_RNA|ZNF625_uc010dyo.1_Silent_p.R82R	NM_145233	NP_660276	Q96I27	ZN625_HUMAN	zinc finger protein 625	48	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTCTGTGGTGCCTATTAAGGG	0.443													17	56					0	0	0	0	T	12256889	T	T	12256889	2	4	138	1	0	0	0	0	0	0	0	1	18116	738	26	4		4	ZNF625	19	12256889	Silent	SNP	C	TCGA-CR-7367-01A-11D-2012-08	1154987	12256889	46872094	180	24927											
ZNF99	7652	broad.mit.edu	37	chr19	22940808	22940808	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatctcatgttttctaagggTtgaggactggctaaaagctt	10	15	10	6	0	2	1	1	1	2	0	3	2	2	2	0	3	1	4	0	3	4	7			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:22940808T>C	uc010xrh.1	-	5	1630	c.1630A>G	c.(1630-1632)ACC>GCC	p.T544A		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTCTAAGGGTTGAGGACTGG	0.373													12	61					0	0	0	0	C	22940808	C	C	22940808	3	2	138	1	0	0	0	0	1	0	0	0	18271	1725	60	5	1494	5	ZNF99	19	22940808	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	10683919	22940808	36188175	181	24928											
C19orf2	8725	broad.mit.edu	37	chr19	30433493	30433494	+	Frame_Shift_Ins	INS	-	C	C																															agacgccccccgacccctcgINScccccttcggccccggcccc																										TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:30433493_30433494insC	uc002nsr.2	+	1	69_70	c.39_40insC	c.(37-42)TCGCCCfs	p.S13fs	C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_5'UTR	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	13_14					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		CCGACCCCTCGCCCCCTTCGGC	0.762													---	---	---								C	30433494	C	C	30433493	7	5	138	1	0	1	1	0	0	0	0	0	1920	1074	38	0	41	0	C19orf2	19	30433493	Frame_Shift_Ins	INS	-	TCGA-CR-7367-01A-11D-2012-08	7492685	30433493	28695490	182	24929											
ACTN4	81	broad.mit.edu	37	chr19	39191741	39191741	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccagcaaaggcgtcaagcTggtctccatcggggcagaag	10	6	14	11	2	2	1	1	0	1	1	4	1	2	1	2	4	3	3	2	4	3	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:39191741T>A	uc002oja.1	+	3	436	c.377T>A	c.(376-378)CTG>CAG	p.L126Q	ACTN4_uc010egc.1_Missense_Mutation_p.L126Q	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	126	Actin-binding.|CH 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGCGTCAAGCTGGTCTCCATC	0.557													21	51					0	0	0	0	A	39191741	A	A	39191741	3	1	138	1	0	0	0	0	1	0	0	0	207	1580	55	5	387	5	ACTN4	19	39191741	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	8758248	39191741	19937242	183	24930											
CEACAM3	1084	broad.mit.edu	37	chr19	42314017	42314017	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctagaaccagcatccagcGtgacctcaaggagcagcagc	12	5	10	14	1	1	2	1	1	0	1	3	3	3	3	4	1	6	3	4	1	3	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:42314017G>A	uc002orn.1	+	4	633	c.557G>A	c.(556-558)CGT>CAT	p.R186H	CEACAM3_uc010eia.1_Intron|CEACAM3_uc002oro.1_RNA	NM_001815	NP_001806	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion	186	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						AGCATCCAGCGTGACCTCAAG	0.592													36	295					0	0	0	0	A	42314017	A	A	42314017	3	1	138	1	0	0	0	0	1	0	0	0	3208	1145	40	1	571	1	CEACAM3	19	42314017	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	3122276	42314017	16814966	184	24931											
ZNF180	7733	broad.mit.edu	37	chr19	45004353	45004353	+	Translation_Start_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccgctggcccgcagcccaGgctgggcctgtcaccgcctc	3	6	13	19	3	1	0	1	0	0	0	3	0	2	0	6	3	1	3	6	3	0	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:45004353G>T	uc002ozf.3	-	1	222	c.-60C>A	c.(-62--58)GCCTG>GCATG		ZNF180_uc002ozh.3_Translation_Start_Site|ZNF180_uc002ozi.3_Translation_Start_Site|ZNF180_uc002ozg.3_Translation_Start_Site|ZNF180_uc010ejm.2_Translation_Start_Site	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				CCGCAGCCCAGGCTGGGCCTG	0.701											OREG0025537	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	76					3.5997e-14	6.56525e-14	1	0	T	45004353	T	T	45004353	1	4	138	1	0	0	0	0	0	0	0	0	17815	1015	35	4		4	ZNF180	19	45004353	Translation_Start_Site	SNP	G	TCGA-CR-7367-01A-11D-2012-08	2690336	45004353	14124630	185	24932											
IRF2BP1	26145	broad.mit.edu	37	chr19	46388533	46388533	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccagacactgcagctgccAgcagcccagggggcatcaag	10	3	14	14	0	1	1	1	0	0	1	1	1	1	1	3	3	5	4	3	3	1	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:46388533A>T	uc002pds.1	-	1	844	c.500T>A	c.(499-501)CTG>CAG	p.L167Q		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		TGCAGCTGCCAGCAGCCCAGG	0.682													9	61					0	0	0	0	T	46388533	T	T	46388533	3	4	138	1	0	0	0	0	1	0	0	0	7868	188	7	5	1258	5	IRF2BP1	19	46388533	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	1384180	46388533	12740450	186	24933											
TSKS	60385	broad.mit.edu	37	chr19	50250010	50250010	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcggcctcctgccgtcGcggcgtctcatcctgcagct	3	9	11	18	5	1	0	1	0	1	0	6	0	3	0	4	2	4	3	4	2	0	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:50250010G>A	uc002ppm.2	-	6	720	c.709C>T	c.(709-711)CGA>TGA	p.R237*		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	237							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		tcctgccgtcgcggcgtctca	0.284													6	34					0	0	0	0	A	50250010	A	A	50250010	4	1	138	1	0	0	0	0	0	1	0	0	16693	1095	38	1	1093	1	TSKS	19	50250010	Nonsense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	3861477	50250010	8878973	187	24934											
MYADM	91663	broad.mit.edu	37	chr19	54377153	54377153	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatcatctaccccaccaccTatgtccagttcctgtcccac	8	10	3	20	0	2	0	1	0	1	0	5	0	5	0	8	0	1	1	8	0	2	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:54377153T>C	uc002qcl.2	+	3	518	c.370T>C	c.(370-372)TAT>CAT	p.Y124H	MYADM_uc002qcm.2_Missense_Mutation_p.Y124H|MYADM_uc002qcn.2_Missense_Mutation_p.Y124H|MYADM_uc002qco.2_Missense_Mutation_p.Y124H|MYADM_uc002qcp.2_Missense_Mutation_p.Y124H	NM_001020820	NP_001018656	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	124	MARVEL 1.					integral to membrane				ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		CCCCACCACCTATGTCCAGTT	0.647													20	129					0	0	0	0	C	54377153	C	C	54377153	3	2	138	1	0	0	0	0	1	0	0	0	10059	1522	53	5	372	5	MYADM	19	54377153	Missense_Mutation	SNP	T	TCGA-CR-7367-01A-11D-2012-08	4127143	54377153	4751830	188	24935											
NLRP2	55655	broad.mit.edu	37	chr19	55481573	55481573	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatcctcaccacccattgtGacagctactgggtggagatg	11	9	10	11	0	1	2	1	1	0	1	2	3	2	2	3	2	2	1	3	2	2	2			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:55481573G>C	uc002qij.2	+	2	276	c.190G>C	c.(190-192)GAC>CAC	p.D64H	NLRP2_uc010yfp.1_Intron|NLRP2_uc010esn.2_Missense_Mutation_p.D64H|NLRP2_uc010eso.2_Missense_Mutation_p.D64H|NLRP2_uc010esp.2_Missense_Mutation_p.D64H	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	64	DAPIN.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CACCCATTGTGACAGCTACTG	0.532													15	74					0	0	0	0	C	55481573	C	C	55481573	3	2	138	1	0	0	0	0	1	0	0	0	10531	1290	45	2	192	2	NLRP2	19	55481573	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	1104420	55481573	3647410	189	24936											
NLRP2	55655	broad.mit.edu	37	chr19	55494909	55494909	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtctgtacgagtctcaggagGaggagctggtgaaggaggtg	9	8	19	5	1	2	1	1	1	2	0	3	6	2	5	0	6	2	2	0	6	2	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:55494909G>T	uc002qij.2	+	6	1929	c.1843G>T	c.(1843-1845)GAG>TAG	p.E615*	NLRP2_uc010yfp.1_Nonsense_Mutation_p.E592*|NLRP2_uc010esn.2_Nonsense_Mutation_p.E591*|NLRP2_uc010eso.2_Nonsense_Mutation_p.E612*|NLRP2_uc010esp.2_Nonsense_Mutation_p.E593*	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	615					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GTCTCAGGAGGAGGAGCTGGT	0.507													12	30					5.50884e-06	9.23386e-06	1	0	T	55494909	T	T	55494909	4	4	138	1	0	0	0	0	0	1	0	0	10531	1175	41	2	1861	2	NLRP2	19	55494909	Nonsense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	13336	55494909	3634074	190	24937											
SBK2	646643	broad.mit.edu	37	chr19	56047567	56047567	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcctcctggccctgctggAgctcctctaatgtcaggccg	5	9	11	16	1	2	0	1	0	1	0	4	1	4	1	5	3	3	2	5	3	1	1			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:56047567A>T	uc010ygc.1	-	1	95	c.95T>A	c.(94-96)CTC>CAC	p.L32H		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	32							ATP binding|protein serine/threonine kinase activity				0						GCCCTGCTGGAGCTCCTCTAA	0.667													4	38					0	0	0	0	T	56047567	T	T	56047567	3	4	138	1	0	0	0	0	1	0	0	0	13926	304	11	5	962	5	SBK2	19	56047567	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	552658	56047567	3081416	191	24938											
ZNF581	51545	broad.mit.edu	37	chr19	56156365	56156365	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacctggcgggtggtgggcGgccccacggctgcccgctct	2	7	16	16	4	2	0	1	0	1	0	2	0	2	0	4	6	1	2	4	6	0	0			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:56156365G>A	uc002qln.2	+	2	1144	c.428G>A	c.(427-429)CGG>CAG	p.R143Q	ZNF581_uc002qlq.2_Missense_Mutation_p.R143Q|CCDC106_uc002qlr.2_5'Flank	NM_016535	NP_057619	Q9P0T4	ZN581_HUMAN	zinc finger protein 581	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		GGTGGTGGGCGGCCCCACGGC	0.667													21	104					0	0	0	0	A	56156365	A	A	56156365	3	1	138	1	0	0	0	0	1	0	0	0	18080	1116	39	1	430	1	ZNF581	19	56156365	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08	108798	56156365	2972618	192	24939											
NLRP4	147945	broad.mit.edu	37	chr19	56369225	56369225	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtacagtgatcattcaaggaCcacaaggaattggaaaaacg	17	7	10	7	1	2	1	2	1	0	0	2	4	2	4	1	3	2	1	1	3	6	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:56369225C>T	uc002qmd.3	+	3	888	c.466C>T	c.(466-468)CCA>TCA	p.P156S	NLRP4_uc002qmf.2_Missense_Mutation_p.P81S|NLRP4_uc010etf.2_5'UTR	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	156	NACHT.|ATP (Potential).						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CATTCAAGGACCACAAGGAAT	0.473													18	151					0	0	0	0	T	56369225	T	T	56369225	3	4	138	1	0	0	0	0	1	0	0	0	10533	507	18	4	472	4	NLRP4	19	56369225	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	212860	56369225	2759758	193	24940											
SNRPB2	6629	broad.mit.edu	37	chr20	16721614	16721614	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggatttaagatcacaccGtcccatgctatgaagatcac	13	9	8	11	1	2	3	2	1	0	2	3	4	3	4	2	1	1	1	2	1	3	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr20:16721614G>A	uc002wph.1	+	7	858	c.642G>A	c.(640-642)CCG>CCA	p.P214P	SNRPB2_uc002wpi.1_Silent_p.P214P	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''	214	RRM 2.					catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						AGATCACACCGTCCCATGCTA	0.413													8	63					0	0	0	0	A	16721614	A	A	16721614	2	1	138	1	0	0	0	0	0	0	0	1	14926	1132	40	1		1	SNRPB2	20	16721614	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08		16721614	46303906	194	24941											
CHD6	84181	broad.mit.edu	37	chr20	40162087	40162087	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctgaggcagacagtgactAgcaacatcttcaattttctc	11	13	7	10	0	4	3	1	2	3	1	5	3	4	3	0	1	2	2	0	1	3	5			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr20:40162087A>G	uc002xka.1	-	3	334	c.156T>C	c.(154-156)GCT>GCC	p.A52A	CHD6_uc002xkd.2_Silent_p.A30A|CHD6_uc002xkc.2_Silent_p.A87A	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	52					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GACAGTGACTAGCAACATCTT	0.448													53	91					0	0	0	0	G	40162087	G	G	40162087	2	3	138	1	0	0	0	0	0	0	0	1	3344	407	15	5		5	CHD6	20	40162087	Silent	SNP	A	TCGA-CR-7367-01A-11D-2012-08	23440473	40162087	22863433	195	24942											
BMP7	655	broad.mit.edu	37	chr20	55803477	55803477	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaattccttgtcatgttccActggaagaggaagagaacac	14	9	10	8	0	1	3	1	0	0	3	3	6	3	5	2	2	1	1	2	2	4	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr20:55803477A>G	uc010gip.1	-	2	948	c.419T>C	c.(418-420)GTG>GCG	p.V140A	BMP7_uc010giq.1_Missense_Mutation_p.V140A|BMP7_uc002xyc.2_Missense_Mutation_p.V140A	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor	140					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			GTCATGTTCCACTGGAAGAGG	0.512													3	114					0	0	0	0	G	55803477	G	G	55803477	3	3	138	1	0	0	0	0	1	0	0	0	1468	173	6	5	900	5	BMP7	20	55803477	Missense_Mutation	SNP	A	TCGA-CR-7367-01A-11D-2012-08	15641390	55803477	7222043	196	24943											
LAMA5	3911	broad.mit.edu	37	chr20	60888727	60888727	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaaggtactggggtaccccCcgacgtagaagacgaagtcg	11	6	14	10	4	0	3	0	1	0	2	1	5	0	3	3	3	2	3	3	3	6	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr20:60888727C>T	uc002ycq.2	-	63	8703	c.8636G>A	c.(8635-8637)GGG>GAG	p.G2879E		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2879	Laminin G-like 1.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGGTACCCCCCGACGTAGAA	0.677													18	76					0	0	0	0	T	60888727	T	T	60888727	3	4	138	1	0	0	0	0	1	0	0	0	8649	623	22	4	2523	4	LAMA5	20	60888727	Missense_Mutation	SNP	C	TCGA-CR-7367-01A-11D-2012-08	5085250	60888727	2136793	197	24944											
POTEH	23784	broad.mit.edu	37	chr22	16267041	16267042	+	Missense_Mutation	DNP	GG	AT	AT																															agcagtggcaccgttagtcaGgttttctgggaatcccatat																										TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr22:16267041_16267042GG>AT	uc010gqp.2	-	9	1459_1460	c.1407_1408CC>AT	c.(1405-1410)AACCTG>AAATTG	p.N469K	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.N188K|POTEH_uc002zlj.1_Missense_Mutation_p.N304K	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	469										skin(1)	1						CCGTTAGTCAGGTTTTCTGGGA	0.401													25	573					0	0	0	0	AT	16267042	AT	AT	16267041	3	1	138	1	0	0	0	0	1	0	0	0	12322	991	35	4	237	4	POTEH	22	16267041	Missense_Mutation	DNP	GG	TCGA-CR-7367-01A-11D-2012-08		16267041	35037525	198	24945											
CELSR1	9620	broad.mit.edu	37	chr22	46859980	46859980	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaagaactggccgcggacGccgccaggcagcagcgccga	9	1	17	14	6	0	1	0	0	0	1	0	4	0	3	4	4	3	2	4	4	2	0	rs148297929	byFrequency	TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr22:46859980G>A	uc003bhw.1	-	2	3807	c.3807C>T	c.(3805-3807)GGC>GGT	p.G1269G		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1269	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GGCCGCGGACGCCGCCAGGCA	0.632													6	48					0	0	0	0	A	46859980	A	A	46859980	2	1	138	1	0	0	0	0	0	0	0	1	3236	1074	38	1		1	CELSR1	22	46859980	Silent	SNP	G	TCGA-CR-7367-01A-11D-2012-08	30592939	46859980	4444586	199	24946											
AKAP4	8852	broad.mit.edu	37	chrX	49957554	49957554	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatggtccaggggctctgtGagattctagttgtttcactg	6	14	14	7	0	3	1	1	1	2	1	4	3	4	2	1	4	0	3	1	4	1	4			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chrX:49957554G>A	uc004dow.1	-	5	1934	c.1810C>T	c.(1810-1812)CAC>TAC	p.H604Y	AKAP4_uc004dov.1_Missense_Mutation_p.H221Y|AKAP4_uc010njp.1_Missense_Mutation_p.H426Y|AKAP4_uc004dou.1_Missense_Mutation_p.H595Y	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	604					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					GGGGCTCTGTGAGATTCTAGT	0.458													18	27					0	0	0	0	A	49957554	A	A	49957554	3	1	138	1	0	0	0	0	1	0	0	0	453	1290	45	2	762	2	AKAP4	23	49957554	Missense_Mutation	SNP	G	TCGA-CR-7367-01A-11D-2012-08		49957554	105313006	200	24947											
KDM5C	8242	broad.mit.edu	37	chrX	53240037	53240038	+	Frame_Shift_Ins	INS	-	A	A																															tccaaccactggtagcatacINStcctgccaggtcaggtattt																										TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chrX:53240037_53240038insA	uc004drz.2	-	11	1936_1937	c.1403_1404insT	c.(1402-1404)GAGfs	p.E468fs	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Frame_Shift_Ins_p.E401fs|KDM5C_uc004dsa.2_Frame_Shift_Ins_p.E467fs	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	468	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						TGGTAGCATACTCCTGCCAGGT	0.455			N|F|S		clear cell renal carcinoma								---	---	---								A	53240038	A	A	53240037	7	5	138	1	0	1	1	0	0	0	0	0	8174	564	20	0	3440	0	KDM5C	23	53240037	Frame_Shift_Ins	INS	-	TCGA-CR-7367-01A-11D-2012-08	3282483	53240037	102030523	201	24948											
H2BFWT	158983	broad.mit.edu	37	chrX	103268089	103268089	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacgtagtggagttggcctcTttgggctcctgggtgatcag	5	12	16	8	1	2	1	1	1	1	0	3	3	3	2	2	4	0	3	2	4	1	3			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chrX:103268089T>C	uc004elr.2	-	1	168	c.144A>G	c.(142-144)AAA>AAG	p.K48K		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	48					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						AGTTGGCCTCTTTGGGCTCCT	0.627													7	10					0	0	0	0	C	103268089	C	C	103268089	2	2	138	1	0	0	0	0	0	0	0	1	6971	1606	56	5		5	H2BFWT	23	103268089	Silent	SNP	T	TCGA-CR-7367-01A-11D-2012-08	50028052	103268089	52002471	202	24949											
ANGPTL7	10218	broad.mit.edu	37	chr1	11249656	11249656	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgctgaaaaagcctctctCagctgtgacctggctctgca	9	10	10	12	0	3	2	1	2	2	0	4	3	3	2	2	1	4	4	2	1	2	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:11249656C>G	uc001ase.2	+	1	259	c.20C>G	c.(19-21)TCA>TGA	p.S7*	MTOR_uc001asd.2_Intron	NM_021146	NP_066969	O43827	ANGL7_HUMAN	angiopoietin-like 7 precursor	7					response to oxidative stress|signal transduction	extracellular region	receptor binding				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.39e-06)|COAD - Colon adenocarcinoma(227;0.000244)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0487)		AAGCCTCTCTCAGCTGTGACC	0.557													18	138					0	0	0	0	G	11249656	G	G	11249656	4	3	139	1	0	0	0	0	0	1	0	0	619	838	29	2	22	2	ANGPTL7	1	11249656	Nonsense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08		11249656	238000965	1	24950											
VPS13D	55187	broad.mit.edu	37	chr1	12337106	12337106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagaagcttcagagaacaagGaacttaccagtctacatatg	17	8	8	8	0	2	2	1	0	1	2	2	4	2	3	1	1	5	1	1	1	8	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:12337106G>A	uc001atv.2	+	19	3602	c.3461G>A	c.(3460-3462)GGA>GAA	p.G1154E	VPS13D_uc001atw.2_Missense_Mutation_p.G1154E|VPS13D_uc001atx.2_Missense_Mutation_p.G342E	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1154					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGAGAACAAGGAACTTACCAG	0.393													5	84					0	0	0	0	A	12337106	A	A	12337106	3	1	139	1	0	0	0	0	1	0	0	0	17260	1174	41	2	3531	2	VPS13D	1	12337106	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1087450	12337106	236913515	2	24951											
PADI3	51702	broad.mit.edu	37	chr1	17609457	17609457	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgctggagccgctgggcctCcactgcaccttcattgatga	6	10	11	14	1	1	2	1	2	0	0	2	3	2	3	4	2	3	3	4	2	0	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:17609457C>G	uc001bai.2	+	16	1918	c.1878C>G	c.(1876-1878)CTC>CTG	p.L626L		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	626					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CGCTGGGCCTCCACTGCACCT	0.587													7	54					0	0	0	0	G	17609457	G	G	17609457	2	3	139	1	0	0	0	0	0	0	0	1	11433	842	30	2		2	PADI3	1	17609457	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	5272351	17609457	231641164	3	24952											
NFYC	4802	broad.mit.edu	37	chr1	41235027	41235027	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaccatcttgattcttacaGattacacagacagaggtcca	13	11	6	11	0	2	4	0	1	2	3	3	4	3	4	2	1	3	0	2	1	3	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:41235027G>A	uc001cge.2	+	9	894	c.886_splice	c.e9-1	p.I296_splice	NFYC_uc001cfx.3_Splice_Site_p.I296_splice|NFYC_uc009vwd.2_Splice_Site_p.I277_splice|NFYC_uc001cfz.2_Splice_Site_p.I277_splice|NFYC_uc010ojn.1_Splice_Site_p.I239_splice|NFYC_uc001cfy.3_Splice_Site_p.I277_splice|NFYC_uc001cgc.2_Splice_Site_p.I243_splice|NFYC_uc001cgb.2_Splice_Site_p.I277_splice|NFYC_uc001cgd.3_Splice_Site_p.I277_splice	NM_001142588	NP_001136060	Q13952	NFYC_HUMAN	nuclear transcription factor Y, gamma isoform 1						protein folding|regulation of transcription from RNA polymerase II promoter	CCAAT-binding factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|kidney(1)	3	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.72e-17)			GATTCTTACAGATTACACAGA	0.463													9	93					0	0	0	0	A	41235027	A	A	41235027	5	1	139	1	0	0	0	0	0	0	1	0	10445	956	33	2	919	2	NFYC	1	41235027	Splice_Site	SNP	G	TCGA-CR-7368-01A-11D-2129-08	23625570	41235027	208015594	4	24953											
KDM4A	9682	broad.mit.edu	37	chr1	44137205	44137205	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actccactgaagtcaaatttGaagagcttaaaaatgtcaaa	18	10	6	7	0	2	3	2	2	0	1	3	3	3	3	1	0	1	1	1	0	7	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:44137205G>A	uc001cjx.2	+	11	1559	c.1393G>A	c.(1393-1395)GAA>AAA	p.E465K	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	465					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						AGTCAAATTTGAAGAGCTTAA	0.418													13	110					0	0	0	0	A	44137205	A	A	44137205	3	1	139	1	0	0	0	0	1	0	0	0	8167	1291	45	2	1431	2	KDM4A	1	44137205	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	2902178	44137205	205113416	5	24954											
RPS8	6202	broad.mit.edu	37	chr1	45243773	45243773	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaatcagcagtctcctggaGgagcagttccagcagggcaa	13	6	12	10	0	2	0	1	0	1	0	4	2	3	2	2	3	3	5	2	3	3	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:45243773G>A	uc001cmi.2	+	5	512	c.489G>A	c.(487-489)GAG>GAA	p.E163E	SNORD38B_uc001cml.2_5'Flank	NM_001012	NP_001003	P62241	RS8_HUMAN	ribosomal protein S8	163					endocrine pancreas development|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					GTCTCCTGGAGGAGCAGTTCC	0.448													3	12					0	0	0	0	A	45243773	A	A	45243773	2	1	139	1	0	0	0	0	0	0	0	1	13726	991	35	4		4	RPS8	1	45243773	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1106568	45243773	204006848	6	24955											
DNAJC6	9829	broad.mit.edu	37	chr1	65858191	65858191	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtgagcaatcagatgatGaacttctgacactttccagt	14	11	8	8	0	2	5	1	4	1	1	3	5	3	5	1	0	2	1	1	0	3	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:65858191G>T	uc001dcd.1	+	12	1539	c.1375G>T	c.(1375-1377)GAA>TAA	p.E459*	DNAJC6_uc001dcc.1_Nonsense_Mutation_p.E490*|DNAJC6_uc010opc.1_Nonsense_Mutation_p.E446*|DNAJC6_uc001dce.1_Nonsense_Mutation_p.E516*	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	459					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						ATCAGATGATGAACTTCTGAC	0.512													11	25					1.61879e-10	1.74143e-10	1	0	T	65858191	T	T	65858191	4	4	139	1	0	0	0	0	0	1	0	0	4675	1291	45	2	1421	2	DNAJC6	1	65858191	Nonsense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	20614418	65858191	183392430	7	24956											
ODF2L	57489	broad.mit.edu	37	chr1	86852635	86852635	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actggtacaccgtggtaaatCttctttctctgatatagttt	9	17	7	8	1	3	1	0	1	3	0	4	1	3	1	1	2	1	3	1	2	5	7			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:86852635C>G	uc001dll.1	-	2	416	c.76G>C	c.(76-78)GAT>CAT	p.D26H	ODF2L_uc001dlm.1_Missense_Mutation_p.D26H|ODF2L_uc001dln.2_Missense_Mutation_p.D26H|ODF2L_uc001dlo.2_5'UTR|ODF2L_uc001dlp.2_Missense_Mutation_p.D26H|ODF2L_uc010osg.1_Missense_Mutation_p.D26H|ODF2L_uc001dlq.1_Intron|ODF2L_uc009wcr.1_Intron	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	26						centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		CGTGGTAAATCTTCTTTCTCT	0.358													7	68					0	0	0	0	G	86852635	G	G	86852635	3	3	139	1	0	0	0	0	1	0	0	0	10882	913	32	2	2078	2	ODF2L	1	86852635	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	20994444	86852635	162397986	8	24957											
DNTTIP2	30836	broad.mit.edu	37	chr1	94342038	94342038	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattacaaacaatgcattgtCacatgacagacttcctgtgt	14	12	6	9	0	1	2	1	1	0	1	2	2	2	2	1	0	3	1	1	0	4	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:94342038C>T	uc001dqf.2	-	2	1491	c.1453G>A	c.(1453-1455)GAC>AAC	p.D485N	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Missense_Mutation_p.D280N	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	485					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		AATGCATTGTCACATGACAGA	0.378													23	41					0	0	0	0	T	94342038	T	T	94342038	3	4	139	1	0	0	0	0	1	0	0	0	4704	826	29	2	841	2	DNTTIP2	1	94342038	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	7489403	94342038	154908583	9	24958											
GNAT2	2780	broad.mit.edu	37	chr1	110151357	110151357	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctccacgagctcaggaggCatggttccctcctcaatgga	9	8	10	14	1	2	0	2	0	0	0	5	3	5	2	4	4	1	3	4	4	1	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:110151357C>T	uc001dya.2	-	4	570	c.357G>A	c.(355-357)ATG>ATA	p.M119I		NM_005272	NP_005263	P19087	GNAT2_HUMAN	guanine nucleotide binding protein, alpha	119					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		GCTCAGGAGGCATGGTTCCCT	0.517													21	49					0	0	0	0	T	110151357	T	T	110151357	3	4	139	1	0	0	0	0	1	0	0	0	6549	710	25	4	727	4	GNAT2	1	110151357	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	15809319	110151357	139099264	10	24959											
SLC16A4	9122	broad.mit.edu	37	chr1	110921808	110921808	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccttgatggtagactcttCtgtctcatggcagtgtgttt	5	17	11	8	0	3	2	1	1	3	1	5	2	4	2	1	2	0	3	1	2	1	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:110921808C>T	uc001dzo.1	-	6	879	c.697G>A	c.(697-699)GAA>AAA	p.E233K	SLC16A4_uc009wfs.1_Missense_Mutation_p.E185K|SLC16A4_uc001dzp.1_Intron|SLC16A4_uc010ovy.1_Missense_Mutation_p.E171K|SLC16A4_uc001dzq.1_Intron|SLC16A4_uc010ovz.1_Missense_Mutation_p.E123K	NM_004696	NP_004687	O15374	MOT5_HUMAN	solute carrier family 16, member 4	233	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			ovary(3)	3		all_cancers(81;0.000476)|all_epithelial(167;0.000401)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0251)|all cancers(265;0.0766)|Epithelial(280;0.0807)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.14)	Pyruvic acid(DB00119)	GTAGACTCTTCTGTCTCATGG	0.423													39	90					0	0	0	0	T	110921808	T	T	110921808	3	4	139	1	0	0	0	0	1	0	0	0	14475	922	32	2	782	2	SLC16A4	1	110921808	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	770451	110921808	138328813	11	24960											
CA14	23632	broad.mit.edu	37	chr1	150235226	150235226	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtgagactaagaatatagcTtatgaacacattctgagtca	15	11	9	6	0	2	4	1	3	1	2	2	5	2	4	0	1	2	1	0	1	6	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:150235226T>G	uc001etx.2	+	6	828	c.519T>G	c.(517-519)GCT>GCG	p.A173A		NM_012113	NP_036245	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV precursor	173	Extracellular (Potential).					integral to membrane	carbonate dehydratase activity|metal ion binding			ovary(1)	1	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGAATATAGCTTATGAACACA	0.363													55	91					0	0	0	0	G	150235226	G	G	150235226	2	3	139	1	0	0	0	0	0	0	0	1	2527	1596	56	5		5	CA14	1	150235226	Silent	SNP	T	TCGA-CR-7368-01A-11D-2129-08	39313418	150235226	99015395	12	24961											
C1orf56	54964	broad.mit.edu	37	chr1	151021004	151021004	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccggtctgggaagctgcaCggcctttccgggcgccttcg	4	8	15	14	5	1	0	0	0	1	0	3	1	2	1	4	4	3	2	4	4	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:151021004C>A	uc001ewn.2	+	1	746	c.681C>A	c.(679-681)CAC>CAA	p.H227Q		NM_017860	NP_060330	Q9BUN1	CA056_HUMAN	hypothetical protein LOC54964 precursor	227						extracellular region					0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGAAGCTGCACGGCCTTTCCG	0.652											OREG0013793	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	83					4.16121e-05	4.36083e-05	1	0	A	151021004	A	A	151021004	3	1	139	1	0	0	0	0	1	0	0	0	2058	535	19	3	683	3	C1orf56	1	151021004	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	785778	151021004	98229617	13	24962											
FLG2	388698	broad.mit.edu	37	chr1	152324824	152324824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtctttgtgagaaccctGagtgcccttcactgtcactg	6	13	11	11	0	3	2	2	2	1	1	3	3	3	2	2	1	2	0	2	1	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:152324824G>A	uc001ezw.3	-	3	5511	c.5438C>T	c.(5437-5439)TCA>TTA	p.S1813L	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1813							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGAACCCTGAGTGCCCTTC	0.537													61	149					0	0	0	0	A	152324824	A	A	152324824	3	1	139	1	0	0	0	0	1	0	0	0	5955	1294	45	2	1741	2	FLG2	1	152324824	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1303820	152324824	96925797	14	24963											
ADAMTS4	9507	broad.mit.edu	37	chr1	161166083	161166083	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgtgtcgcaagtggagactCcacacaggtcctgtggagag	9	7	15	10	2	0	2	0	0	0	2	3	4	2	2	2	3	0	1	2	3	1	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:161166083C>A	uc001fyt.3	-	3	1396	c.968G>T	c.(967-969)GGA>GTA	p.G323V	ADAMTS4_uc001fyu.2_3'UTR	NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	323	Peptidase M12B.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			AGTGGAGACTCCACACAGGTC	0.597													12	59					3.07112e-06	3.23036e-06	1	0	A	161166083	A	A	161166083	3	1	139	1	0	0	0	0	1	0	0	0	268	855	30	2	1573	2	ADAMTS4	1	161166083	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	8841259	161166083	88084538	15	24964											
DDR2	4921	broad.mit.edu	37	chr1	162749994	162749994	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acgaagaaccgtccctcattCcaagaaatccaccttctgct	12	9	5	15	2	2	2	1	0	1	2	5	3	5	2	5	0	2	1	5	0	4	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:162749994C>G	uc001gcf.2	+	19	2991	c.2526C>G	c.(2524-2526)TTC>TTG	p.F842L	DDR2_uc001gcg.2_Missense_Mutation_p.F842L|uc001gch.1_5'Flank	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	842	Cytoplasmic (Potential).|Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GTCCCTCATTCCAAGAAATCC	0.522													8	98					0	0	0	0	G	162749994	G	G	162749994	3	3	139	1	0	0	0	0	1	0	0	0	4354	854	30	2	2588	2	DDR2	1	162749994	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	1583911	162749994	86500627	16	24965											
CFH	3075	broad.mit.edu	37	chr1	196658599	196658599	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catggaggtctatatcatgaGaatatgcgtagaccatactt	13	12	9	7	1	2	2	1	1	1	2	2	4	2	3	1	2	2	1	1	2	6	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:196658599G>A	uc001gtj.3	+	8	1254	c.1014G>A	c.(1012-1014)GAG>GAA	p.E338E	CFH_uc001gti.3_Silent_p.E338E|CFH_uc009wyw.2_Intron|CFH_uc009wyx.2_Silent_p.E274E	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	338	Sushi 6.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TATATCATGAGAATATGCGTA	0.313													12	62					0	0	0	0	A	196658599	A	A	196658599	2	1	139	1	0	0	0	0	0	0	0	1	3298	933	33	2		2	CFH	1	196658599	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	33908605	196658599	52592022	17	24966											
ATP6V1G3	127124	broad.mit.edu	37	chr1	198509756	198509756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgcctgaagaagctggtGgatcccctgagactggcttg	7	11	13	10	0	1	3	0	2	1	2	2	5	2	4	3	3	2	2	3	3	2	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:198509756G>A	uc001gup.2	-	2	131	c.25C>T	c.(25-27)CAC>TAC	p.H9Y	ATP6V1G3_uc009wzd.2_Missense_Mutation_p.H9Y|ATP6V1G3_uc001guo.2_Missense_Mutation_p.H9Y	NM_133262	NP_573569	Q96LB4	VATG3_HUMAN	ATPase, H+ transporting, lysosomal, V1 subunit	9	Potential.				cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding			central_nervous_system(1)	1						AGAAGCTGGTGGATCCCCTGA	0.448													43	70					0	0	0	0	A	198509756	A	A	198509756	3	1	139	1	0	0	0	0	1	0	0	0	1190	1348	47	4	393	4	ATP6V1G3	1	198509756	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1851157	198509756	50740865	18	24967											
KIF14	9928	broad.mit.edu	37	chr1	200549426	200549426	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aagtttagattcaaacttttCcagactccagaatgttgaga	14	13	7	7	0	1	4	1	1	0	4	3	5	3	4	2	0	1	2	2	0	4	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:200549426C>G	uc010ppk.1	-	21	3860	c.3421G>C	c.(3421-3423)GAA>CAA	p.E1141Q	KIF14_uc010ppj.1_Missense_Mutation_p.E650Q	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1141	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TCAAACTTTTCCAGACTCCAG	0.264													6	16					0	0	0	0	G	200549426	G	G	200549426	3	3	139	1	0	0	0	0	1	0	0	0	8315	864	30	2	1565	2	KIF14	1	200549426	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	2039670	200549426	48701195	19	24968											
LMOD1	25802	broad.mit.edu	37	chr1	201868676	201868676	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatccttcttctctccctTggcttcctgtgcctgccttt	2	17	6	16	0	2	1	0	0	2	1	6	1	5	1	5	1	2	1	5	1	0	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:201868676T>G	uc001gxb.2	-	2	1713	c.1465A>C	c.(1465-1467)AAG>CAG	p.K489Q	LMOD1_uc010ppu.1_Missense_Mutation_p.K438Q	NM_012134	NP_036266	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	489					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			ovary(1)|pancreas(1)|skin(1)	3						TTCTCTCCCTTGGCTTCCTGT	0.592													11	16					0	0	0	0	G	201868676	G	G	201868676	3	3	139	1	0	0	0	0	1	0	0	0	8898	1821	63	5	345	5	LMOD1	1	201868676	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08	1319250	201868676	47381945	20	24969											
C4BPA	722	broad.mit.edu	37	chr1	207286390	207286390	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgcaccccccaaaaactcCatctggggctcttcatagaa	12	8	6	15	0	3	1	1	0	2	1	4	1	4	1	4	2	2	2	4	2	4	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:207286390C>T	uc001hfo.2	+	2	214	c.20C>T	c.(19-21)CCA>CTA	p.P7L		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	7					complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CCAAAAACTCCATCTGGGGCT	0.393													16	32					0	0	0	0	T	207286390	T	T	207286390	3	4	139	1	0	0	0	0	1	0	0	0	2259	594	21	4	22	4	C4BPA	1	207286390	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	5417714	207286390	41964231	21	24970											
MTR	4548	broad.mit.edu	37	chr1	236995364	236995364	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agtttgctaaactcatcatgGcaggaaactatgaagtgagc	14	10	10	7	0	2	2	2	2	0	0	2	3	2	3	0	2	4	3	0	2	5	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:236995364G>T	uc001hyi.3	+	13	1597	c.1174G>T	c.(1174-1176)GCA>TCA	p.A392S	MTR_uc010pxw.1_Intron|MTR_uc010pxx.1_Missense_Mutation_p.A392S|MTR_uc010pxy.1_Missense_Mutation_p.A392S	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	392	Pterin-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	ACTCATCATGGCAGGAAACTA	0.448													6	48					2.0095e-06	2.12155e-06	1	0	T	236995364	T	T	236995364	3	4	139	1	0	0	0	0	1	0	0	0	10011	1203	42	4	1224	4	MTR	1	236995364	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	29708974	236995364	12255257	22	24971											
EXO1	9156	broad.mit.edu	37	chr1	242045251	242045251	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atattaagttacttgacagtCaaagtgaccagacctccaag	15	10	7	9	0	1	3	1	2	0	1	2	3	2	3	3	0	1	1	3	0	5	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:242045251C>T	uc001hzh.2	+	14	2683	c.2143C>T	c.(2143-2145)CAA>TAA	p.Q715*	EXO1_uc001hzi.2_Nonsense_Mutation_p.Q715*|EXO1_uc001hzj.2_Nonsense_Mutation_p.Q715*|EXO1_uc009xgq.2_Nonsense_Mutation_p.Q714*	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	715	Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			ACTTGACAGTCAAAGTGACCA	0.279								Direct_reversal_of_damage|Editing_and_processing_nucleases					4	44					0	0	0	0	T	242045251	T	T	242045251	4	4	139	1	0	0	0	0	0	1	0	0	5324	827	29	2	2185	2	EXO1	1	242045251	Nonsense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	5049887	242045251	7205370	23	24972											
OR2M2	391194	broad.mit.edu	37	chr1	248343777	248343777	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcattgatgctgtagccacaTtttccttctccttttgtggg	5	18	8	10	0	2	1	1	1	1	0	4	1	3	1	3	1	2	2	3	1	1	7			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr1:248343777T>C	uc010pzf.1	+	1	490	c.490T>C	c.(490-492)TTT>CTT	p.F164L		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	164	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGTAGCCACATTTTCCTTCTC	0.418													115	182					0	0	0	0	C	248343777	C	C	248343777	3	2	139	1	0	0	0	0	1	0	0	0	11064	1493	52	5	492	5	OR2M2	1	248343777	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08	6298526	248343777	906844	24	24973											
KCNS3	3790	broad.mit.edu	37	chr2	18113159	18113159	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccagatcctacggcttaTgaggattttccgaattctaa	10	13	9	9	2	1	2	0	1	1	1	4	4	4	3	3	3	1	1	3	3	4	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:18113159T>G	uc002rcv.2	+	3	1335	c.884T>G	c.(883-885)ATG>AGG	p.M295R	KCNS3_uc002rcw.2_Missense_Mutation_p.M295R	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	295	Helical; Name=Segment S4; (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTACGGCTTATGAGGATTTTC	0.498													30	61					0	0	0	0	G	18113159	G	G	18113159	3	3	139	1	0	0	0	0	1	0	0	0	8129	1464	51	5	886	5	KCNS3	2	18113159	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08		18113159	225086214	25	24974											
STRN	6801	broad.mit.edu	37	chr2	37126701	37126701	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacgcttttctctcttccatCaacatcatcatcttcatctt	8	17	2	14	1	8	0	4	0	4	0	10	1	9	0	1	0	1	1	1	0	1	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:37126701C>T	uc002rpn.2	-	6	769	c.760G>A	c.(760-762)GAT>AAT	p.D254N	STRN_uc010ezx.2_Missense_Mutation_p.D254N	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	254					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TCTCTTCCATCAACATCATCA	0.338													4	47					0	0	0	0	T	37126701	T	T	37126701	3	4	139	1	0	0	0	0	1	0	0	0	15395	826	29	2	1634	2	STRN	2	37126701	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	19013542	37126701	206072672	26	24975											
ABCG8	64241	broad.mit.edu	37	chr2	44079964	44079964	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtccagtatttcacagccatCggctacccctgtcctcgcta	7	11	7	16	2	1	0	1	0	0	0	5	0	3	0	5	1	2	3	5	1	3	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:44079964C>T	uc002rtq.2	+	6	1011	c.921C>T	c.(919-921)ATC>ATT	p.I307I	ABCG8_uc010yoa.1_Silent_p.I307I	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	307	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCACAGCCATCGGCTACCCCT	0.592													11	92					0	0	0	0	T	44079964	T	T	44079964	2	4	139	1	0	0	0	0	0	0	0	1	72	874	31	1		1	ABCG8	2	44079964	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	6953263	44079964	199119409	27	24976											
ABCG8	64241	broad.mit.edu	37	chr2	44102445	44102445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattatggccctggccgccgCggccctgctccccaccttcc	3	8	10	20	3	0	0	0	0	0	0	2	1	2	0	8	3	1	1	8	3	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:44102445C>T	uc002rtq.2	+	11	1739	c.1649C>T	c.(1648-1650)GCG>GTG	p.A550V	ABCG8_uc010yoa.1_Missense_Mutation_p.A549V	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	550	Helical; Name=4; (Potential).|ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGGCCGCCGCGGCCCTGCTC	0.617													18	49					0	0	0	0	T	44102445	T	T	44102445	3	4	139	1	0	0	0	0	1	0	0	0	72	768	27	1	1691	1	ABCG8	2	44102445	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	22481	44102445	199096928	28	24977											
USP34	9736	broad.mit.edu	37	chr2	61431396	61431396	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcatcccaacataccttacTggtttccaccattgtgggca	9	11	8	13	0	0	0	0	0	0	0	2	0	2	0	4	3	3	3	4	3	3	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:61431396T>C	uc002sbe.2	-	74	9401	c.9379A>G	c.(9379-9381)AGT>GGT	p.S3127G	USP34_uc002sbd.2_Intron	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3127					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CATACCTTACTGGTTTCCACC	0.428													44	72					0	0	0	0	C	61431396	C	C	61431396	3	2	139	1	0	0	0	0	1	0	0	0	17133	1580	55	5	1289	5	USP34	2	61431396	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08	17328951	61431396	181767977	29	24978											
LRRTM1	347730	broad.mit.edu	37	chr2	80530075	80530075	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggctcgatgtaggtgaggcgGttggagtccagctgcaggga	7	8	19	7	2	0	1	0	1	0	0	2	4	1	3	1	6	2	5	1	6	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:80530075G>T	uc002sok.1	-	2	1140	c.870C>A	c.(868-870)AAC>AAA	p.N290K	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	290	LRR 9.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						AGGTGAGGCGGTTGGAGTCCA	0.602										HNSCC(69;0.2)			13	32					1.5739e-10	1.69957e-10	1	0	T	80530075	T	T	80530075	3	4	139	1	0	0	0	0	1	0	0	0	9089	1252	44	4	702	4	LRRTM1	2	80530075	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	19098679	80530075	162669298	30	24979											
SLC5A7	60482	broad.mit.edu	37	chr2	108604753	108604753	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatcatagttggtggccgaGatattggtttattggttggt	7	16	13	5	1	1	1	1	0	0	1	1	2	1	1	2	5	0	3	2	5	3	8			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:108604753G>A	uc002tdv.2	+	2	418	c.142G>A	c.(142-144)GAT>AAT	p.D48N	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.D48N|SLC5A7_uc010ywn.1_Intron	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	48	Extracellular (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TGGTGGCCGAGATATTGGTTT	0.527													4	66					0	0	0	0	A	108604753	A	A	108604753	3	1	139	1	0	0	0	0	1	0	0	0	14734	942	33	2	144	2	SLC5A7	2	108604753	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	28074678	108604753	134594620	31	24980											
TTL	150465	broad.mit.edu	37	chr2	113251798	113251798	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgatttatccaaccaatctCaagactccagttgctccagc	11	11	6	13	0	1	2	1	1	1	1	5	2	4	2	4	0	3	2	4	0	4	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:113251798C>G	uc002thu.2	+	3	494	c.315C>G	c.(313-315)CTC>CTG	p.L105L		NM_153712	NP_714923	Q8NG68	TTL_HUMAN	tubulin tyrosine ligase	105	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0		Ovarian(717;0.024)		BRCA - Breast invasive adenocarcinoma(221;6.17e-07)|STAD - Stomach adenocarcinoma(1183;0.00644)		CAACCAATCTCAAGACTCCAG	0.443			T	ETV6	ALL								10	52					0	0	0	0	G	113251798	G	G	113251798	2	3	139	1	0	0	0	0	0	0	0	1	16789	813	29	2		2	TTL	2	113251798	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	4647045	113251798	129947575	32	24981											
UBXN4	23190	broad.mit.edu	37	chr2	136528186	136528186	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagaaaaactggaaaagaaAtgttggattataaaagaaaa	23	7	10	1	0	0	3	0	0	0	3	0	6	0	5	0	3	1	1	0	3	10	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:136528186A>G	uc002tur.2	+	8	1014	c.703A>G	c.(703-705)ATG>GTG	p.M235V	UBXN4_uc002tus.2_Missense_Mutation_p.M1V	NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	235	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						TGGAAAAGAAATGTTGGATTA	0.328													8	13					0	0	0	0	G	136528186	G	G	136528186	3	3	139	1	0	0	0	0	1	0	0	0	16984	101	4	5	733	5	UBXN4	2	136528186	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	23276388	136528186	106671187	33	24982											
ARL6IP6	151188	broad.mit.edu	37	chr2	153575279	153575279	+	Frame_Shift_Del	DEL	A	-	-																															gaagtcgacgaggaggagggAtgcgaccaagtggcccgcga																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:153575279delA	uc002tyn.2	+	1	857	c.141delA	c.(139-141)GGAfs	p.G47fs	ARL6IP6_uc002tym.2_Intron|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_5'Flank|PRPF40A_uc010zcd.1_5'Flank|PRPF40A_uc002tyi.2_5'Flank|PRPF40A_uc002tyj.2_5'Flank|PRPF40A_uc002tyl.1_5'Flank	NM_152522	NP_689735	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting	47						integral to membrane					0						AGGAGGAGGGATGCGACCAAG	0.706													---	---	---								-	153575279	-	-	153575279	7	5	139	1	0	1	0	1	0	0	0	0	947	320	12	0	143	0	ARL6IP6	2	153575279	Frame_Shift_Del	DEL	A	TCGA-CR-7368-01A-11D-2129-08	17047093	153575279	89624094	34	24983											
FAP	2191	broad.mit.edu	37	chr2	163055300	163055300	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcatagtacttggcgtagtCgctgaaacttgctgtgtaat	9	14	11	7	2	0	1	0	1	0	0	1	1	0	1	0	1	4	6	0	1	5	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:163055300C>T	uc002ucd.2	-	16	1577	c.1369G>A	c.(1369-1371)GAC>AAC	p.D457N	FAP_uc010fpc.2_5'UTR|FAP_uc010zct.1_Missense_Mutation_p.D432N|FAP_uc010fpd.2_5'UTR	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	457	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						TTGGCGTAGTCGCTGAAACTT	0.468													20	41					0	0	0	0	T	163055300	T	T	163055300	3	4	139	1	0	0	0	0	1	0	0	0	5705	884	31	1	957	1	FAP	2	163055300	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	9480021	163055300	80144073	35	24984											
XIRP2	129446	broad.mit.edu	37	chr2	168103755	168103755	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaaaaaagatgctaaagcTgtgatggcaggatcctcggg	15	8	12	6	1	0	2	0	1	0	1	2	3	1	3	1	3	2	3	1	3	6	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:168103755T>G	uc002udx.2	+	8	5871	c.5853T>G	c.(5851-5853)GCT>GCG	p.A1951A	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.A1776A|XIRP2_uc010fpq.2_Silent_p.A1729A|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1776					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATGCTAAAGCTGTGATGGCAG	0.403													8	43					0	0	0	0	G	168103755	G	G	168103755	2	3	139	1	0	0	0	0	0	0	0	1	17498	1567	55	5		5	XIRP2	2	168103755	Silent	SNP	T	TCGA-CR-7368-01A-11D-2129-08	5048455	168103755	75095618	36	24985											
TTN	7273	broad.mit.edu	37	chr2	179635006	179635006	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaaggcaacagtggcattttCcaaggctgtcacatcctttg	11	11	9	10	0	1	0	1	0	0	0	3	0	3	0	2	3	1	3	2	3	3	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:179635006C>G	uc010zfg.1	-	36	8646	c.8422G>C	c.(8422-8424)GAA>CAA	p.E2808Q	TTN_uc010zfh.1_Missense_Mutation_p.E2762Q|TTN_uc010zfi.1_Missense_Mutation_p.E2762Q|TTN_uc010zfj.1_Missense_Mutation_p.E2762Q|TTN_uc002unb.2_Missense_Mutation_p.E2808Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2808							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGCATTTTCCAAGGCTGTC	0.408													16	88					0	0	0	0	G	179635006	G	G	179635006	3	3	139	1	0	0	0	0	1	0	0	0	16803	864	30	2	102874	2	TTN	2	179635006	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	11531251	179635006	63564367	37	24986											
COL3A1	1281	broad.mit.edu	37	chr2	189873853	189873853	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcactcaagtctgttaatggAcaaatagaaagcctcattag	15	11	7	8	0	4	1	3	0	1	1	4	2	4	2	1	1	1	1	1	1	6	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:189873853A>G	uc002uqj.1	+	48	3846	c.3729A>G	c.(3727-3729)GGA>GGG	p.G1243G		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1243	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGTTAATGGACAAATAGAAA	0.423													5	106					0	0	0	0	G	189873853	G	G	189873853	2	3	139	1	0	0	0	0	0	0	0	1	3703	262	10	5		5	COL3A1	2	189873853	Silent	SNP	A	TCGA-CR-7368-01A-11D-2129-08	10238847	189873853	53325520	38	24987											
ANKAR	150709	broad.mit.edu	37	chr2	190559831	190559831	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttccactgacagatgctCaattacatgaacaatttaag	15	11	6	9	0	1	3	1	2	0	1	2	4	2	3	1	0	3	1	1	0	5	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:190559831C>G	uc002uqw.1	+	5	1219	c.1219C>G	c.(1219-1221)CAA>GAA	p.Q407E	ANKAR_uc002uqu.2_RNA	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	478						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			GACAGATGCTCAATTACATGA	0.338													4	47					0	0	0	0	G	190559831	G	G	190559831	3	3	139	1	0	0	0	0	1	0	0	0	623	827	29	2	1450	2	ANKAR	2	190559831	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	685978	190559831	52639542	39	24988											
PLCL1	5334	broad.mit.edu	37	chr2	198949886	198949886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaagttgccttctgatccaGatgtgttagaaggagaagta	13	11	12	5	0	1	5	0	1	1	4	2	6	2	5	2	1	1	3	2	1	5	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:198949886G>C	uc010fsp.2	+	2	1936	c.1645G>C	c.(1645-1647)GAT>CAT	p.D549H	PLCL1_uc002uuv.3_Missense_Mutation_p.D470H	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	549	Interaction with GABA A beta subunit (By similarity).				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TTCTGATCCAGATGTGTTAGA	0.413													20	41					0	0	0	0	C	198949886	C	C	198949886	3	2	139	1	0	0	0	0	1	0	0	0	12094	942	33	2	1651	2	PLCL1	2	198949886	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	8390055	198949886	44249487	40	24989											
NOP58	51602	broad.mit.edu	37	chr2	203157551	203157551	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctatgaatatctacaaaatCgaatgatggccattgcaccc	14	11	6	10	1	2	2	0	2	2	0	3	3	2	2	2	1	2	1	2	1	7	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:203157551C>T	uc002uzb.2	+	9	982	c.832C>T	c.(832-834)CGA>TGA	p.R278*	SNORD11_uc002uzd.1_5'Flank	NM_015934	NP_057018	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein homolog	278	Nop.				cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding				0						TCTACAAAATCGAATGATGGC	0.358													7	106					0	0	0	0	T	203157551	T	T	203157551	4	4	139	1	0	0	0	0	0	1	0	0	10594	876	31	1	866	1	NOP58	2	203157551	Nonsense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	4207665	203157551	40041822	41	24990											
SPEG	10290	broad.mit.edu	37	chr2	220354138	220354138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggcccggcctcctgactctCctacctcactggccccaccc	4	7	8	22	1	2	1	1	1	1	0	4	1	3	1	8	3	1	0	8	3	1	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:220354138C>T	uc010fwg.2	+	36	8398	c.8398C>T	c.(8398-8400)CCT>TCT	p.P2800S		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2800	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCCTGACTCTCCTACCTCACT	0.627													4	15					0	0	0	0	T	220354138	T	T	220354138	3	4	139	1	0	0	0	0	1	0	0	0	15102	855	30	2	8552	2	SPEG	2	220354138	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	17196587	220354138	22845235	42	24991											
UGT1A10	54575	broad.mit.edu	37	chr2	234545520	234545520	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttcatccagtggttttcttGacttatttttttcgcattgc	5	21	7	8	1	2	1	1	1	1	0	4	1	3	1	1	1	1	3	1	1	1	9	rs45458396		TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr2:234545520G>C	uc002vur.2	+	1	398	c.352G>C	c.(352-354)GAC>CAC	p.D118H	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Missense_Mutation_p.D118H	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	118					flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGGTTTTCTTGACTTATTTTT	0.368													13	106					0	0	0	0	C	234545520	C	C	234545520	3	2	139	1	0	0	0	0	1	0	0	0	17013	1290	45	2	354	2	UGT1A10	2	234545520	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	14191382	234545520	8653853	43	24992											
CNTN6	27255	broad.mit.edu	37	chr3	1363508	1363508	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccttgcaaagggtcaactCattttttatggtgagctaat	12	14	8	7	0	2	1	2	1	0	0	2	1	2	1	1	2	4	2	1	2	5	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:1363508C>G	uc003boz.2	+	8	1203	c.936C>G	c.(934-936)CTC>CTG	p.L312L	CNTN6_uc011asj.1_Silent_p.L240L|CNTN6_uc003bpa.2_Silent_p.L312L	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	312					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AGGGTCAACTCATTTTTTATG	0.348													21	25					0	0	0	0	G	1363508	G	G	1363508	2	3	139	1	0	0	0	0	0	0	0	1	3660	813	29	2		2	CNTN6	3	1363508	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08		1363508	196658922	44	24993											
CAPN7	23473	broad.mit.edu	37	chr3	15276644	15276644	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgctgttttggatattagaGagttcaaggttttgccttaa	10	17	10	4	0	1	1	1	0	0	1	1	3	1	2	1	2	2	4	1	2	4	8			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:15276644G>C	uc003bzn.2	+	12	1669	c.1399G>C	c.(1399-1401)GAG>CAG	p.E467Q		NM_014296	NP_055111	Q9Y6W3	CAN7_HUMAN	calpain 7	467	Calpain catalytic.				proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1						GGATATTAGAGAGTTCAAGGT	0.393													5	22					0	0	0	0	C	15276644	C	C	15276644	3	2	139	1	0	0	0	0	1	0	0	0	2643	943	33	2	1445	2	CAPN7	3	15276644	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	13913136	15276644	182745786	45	24994											
SATB1	6304	broad.mit.edu	37	chr3	18390856	18390856	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtttgccgtggtgcttgaGatagtaccgctggttctgaa	7	13	13	8	2	1	2	0	2	1	1	1	3	1	2	2	2	3	5	2	2	3	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:18390856G>C	uc003cbh.2	-	11	3833	c.2098C>G	c.(2098-2100)CTC>GTC	p.L700V	SATB1_uc003cbi.2_Missense_Mutation_p.L732V|SATB1_uc003cbj.2_Missense_Mutation_p.L700V	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	700	Homeobox.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						TGGTGCTTGAGATAGTACCGC	0.507													7	134					0	0	0	0	C	18390856	C	C	18390856	3	2	139	1	0	0	0	0	1	0	0	0	13918	942	33	2	197	2	SATB1	3	18390856	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	3114212	18390856	179631574	46	24995											
SNRK	54861	broad.mit.edu	37	chr3	43344765	43344765	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atctggataaaaccttgggtCgaggccattttgccgtggtt	8	13	12	8	2	1	0	0	0	1	0	2	2	1	1	3	4	2	1	3	4	2	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:43344765C>T	uc003cms.3	+	3	402	c.70C>T	c.(70-72)CGA>TGA	p.R24*	SNRK_uc003cmt.3_Nonsense_Mutation_p.R24*|SNRK_uc010hik.2_Nonsense_Mutation_p.R24*|SNRK_uc011azr.1_Intron|SNRK_uc003cmu.2_Nonsense_Mutation_p.R24*	NM_017719	NP_060189	Q9NRH2	SNRK_HUMAN	SNF related kinase	24	ATP (By similarity).|Protein kinase.				myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		AACCTTGGGTCGAGGCCATTT	0.423													22	27					0	0	0	0	T	43344765	T	T	43344765	4	4	139	1	0	0	0	0	0	1	0	0	14915	876	31	1	72	1	SNRK	3	43344765	Nonsense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	24953909	43344765	154677665	47	24996											
MAP4	4134	broad.mit.edu	37	chr3	47957727	47957727	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcagacatacgttcttgatGagaactacttctgtttctgg	9	14	10	8	1	3	3	0	2	3	2	3	4	3	3	0	2	3	3	0	2	3	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:47957727G>A	uc003csb.2	-	7	2116	c.1590C>T	c.(1588-1590)CTC>CTT	p.L530L	MAP4_uc003csc.3_Silent_p.L530L|MAP4_uc011bbf.1_Silent_p.L507L|MAP4_uc003csf.3_Silent_p.L547L	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	530	17 X 14 AA tandem repeats.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CGTTCTTGATGAGAACTACTT	0.502													36	33					0	0	0	0	A	47957727	A	A	47957727	2	1	139	1	0	0	0	0	0	0	0	1	9311	1277	45	2		2	MAP4	3	47957727	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	4612962	47957727	150064703	48	24997											
PRICKLE2	166336	broad.mit.edu	37	chr3	64085380	64085380	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaggtctctgtagccaaTggggttgctgagctggtgga	6	11	16	8	0	1	1	0	1	1	0	2	2	1	2	1	5	4	5	1	5	2	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:64085380T>A	uc003dmf.2	-	8	2468	c.1882A>T	c.(1882-1884)ATT>TTT	p.I628F		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	628						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CTGTAGCCAATGGGGTTGCTG	0.602													35	34					0	0	0	0	A	64085380	A	A	64085380	3	1	139	1	0	0	0	0	1	0	0	0	12549	1464	51	5	656	5	PRICKLE2	3	64085380	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08	16127653	64085380	133937050	49	24998											
CD80	941	broad.mit.edu	37	chr3	119246643	119246643	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggcgtacactttcccttCtcaatctctcattcctcctt	6	15	4	16	1	3	0	2	0	2	0	8	0	6	0	3	1	1	1	3	1	2	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:119246643C>T	uc003ecq.2	-	6	1237	c.842G>A	c.(841-843)AGA>AAA	p.R281K	CD80_uc010hqt.1_Missense_Mutation_p.R249K|CD80_uc010hqu.1_Missense_Mutation_p.R155K	NM_005191	NP_005182	P33681	CD80_HUMAN	CD80 antigen precursor	281	Cytoplasmic (Potential).				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2					Abatacept(DB01281)	ACTTTCCCTTCTCAATCTCTC	0.453													11	95					0	0	0	0	T	119246643	T	T	119246643	3	4	139	1	0	0	0	0	1	0	0	0	3053	913	32	2	28	2	CD80	3	119246643	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	55161263	119246643	78775787	50	24999											
PODXL2	50512	broad.mit.edu	37	chr3	127379318	127379318	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctctcccttgcccaagatGaatctggttgagcctccctg	6	11	8	16	0	2	3	0	2	2	1	4	3	3	3	5	1	2	1	5	1	2	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:127379318G>A	uc003ejq.2	+	3	471	c.447G>A	c.(445-447)ATG>ATA	p.M149I		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	149	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						TGCCCAAGATGAATCTGGTTG	0.348													17	68					0	0	0	0	A	127379318	A	A	127379318	3	1	139	1	0	0	0	0	1	0	0	0	12236	1290	45	2	457	2	PODXL2	3	127379318	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	8132675	127379318	70643112	51	25000											
ATP2C1	27032	broad.mit.edu	37	chr3	130714944	130714944	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	attaaaaatttcgttagattCcagctgagcacgtaagtttg	13	14	8	6	2	0	2	0	1	0	1	2	2	1	2	1	0	2	5	1	0	5	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:130714944C>T	uc003enl.2	+	23	2337	c.2115C>T	c.(2113-2115)TTC>TTT	p.F705F	ATP2C1_uc011blg.1_Silent_p.F739F|ATP2C1_uc011blh.1_Silent_p.F700F|ATP2C1_uc011bli.1_Silent_p.F739F|ATP2C1_uc003enk.2_Silent_p.F689F|ATP2C1_uc003enm.2_Silent_p.F705F|ATP2C1_uc003enn.2_Silent_p.F689F|ATP2C1_uc003eno.2_Silent_p.F705F|ATP2C1_uc003enp.2_Silent_p.F705F|ATP2C1_uc003enq.2_Silent_p.F705F|ATP2C1_uc003enr.2_Silent_p.F705F|ATP2C1_uc003ens.2_Silent_p.F705F|ATP2C1_uc003ent.2_Silent_p.F705F|ATP2C1_uc003enu.2_Silent_p.F383F	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	705	Helical; Name=5; (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TCGTTAGATTCCAGCTGAGCA	0.318									Hailey-Hailey_disease				9	162					0	0	0	0	T	130714944	T	T	130714944	2	4	139	1	0	0	0	0	0	0	0	1	1145	854	30	2		2	ATP2C1	3	130714944	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	3335626	130714944	67307486	52	25001											
DNAJC13	23317	broad.mit.edu	37	chr3	132196904	132196904	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtttatgtttacaagccCttgctattgtttatggcaga	9	17	9	6	0	0	1	0	0	0	1	0	1	0	1	1	1	3	5	1	1	5	9			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:132196904C>T	uc003eor.2	+	24	2694	c.2629C>T	c.(2629-2631)CTT>TTT	p.L877F		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	877							heat shock protein binding			ovary(1)|breast(1)	2						TTTACAAGCCCTTGCTATTGT	0.333													22	92					0	0	0	0	T	132196904	T	T	132196904	3	4	139	1	0	0	0	0	1	0	0	0	4654	681	24	4	2719	4	DNAJC13	3	132196904	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	1481960	132196904	65825526	53	25002											
RFC4	5984	broad.mit.edu	37	chr3	186507820	186507820	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgatgagttgcaaatgttCatcagcaccatctgctaggc	10	11	10	10	0	3	2	2	2	1	0	3	2	3	2	1	1	3	6	1	1	2	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:186507820C>G	uc003fqz.2	-	11	1253	c.1030G>C	c.(1030-1032)GAA>CAA	p.E344Q	RFC4_uc011bsc.1_Missense_Mutation_p.E344Q	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	344					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TGCAAATGTTCATCAGCACCA	0.378													9	79					0	0	0	0	G	186507820	G	G	186507820	3	3	139	1	0	0	0	0	1	0	0	0	13312	835	29	2	65	2	RFC4	3	186507820	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	54310916	186507820	11514610	54	25003											
RFC4	5984	broad.mit.edu	37	chr3	186507847	186507847	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accatctgctaggcatttgtCaacttcctacgagaaaaatt	13	12	6	10	1	2	1	1	0	1	1	3	2	3	1	2	1	3	2	2	1	5	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr3:186507847C>T	uc003fqz.2	-	11	1226	c.1003G>A	c.(1003-1005)GAC>AAC	p.D335N	RFC4_uc011bsc.1_Missense_Mutation_p.D335N	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	335					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		AGGCATTTGTCAACTTCCTAC	0.378													9	71					0	0	0	0	T	186507847	T	T	186507847	3	4	139	1	0	0	0	0	1	0	0	0	13312	826	29	2	92	2	RFC4	3	186507847	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	27	186507847	11514583	55	25004											
EVC	2121	broad.mit.edu	37	chr4	5811288	5811288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgagctggcagccttggcccGagtgccccttgctgaaagca	7	7	13	14	2	0	1	0	1	0	0	0	3	0	1	4	2	5	4	4	2	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:5811288G>A	uc003gil.1	+	19	2916	c.2732G>A	c.(2731-2733)CGA>CAA	p.R911Q	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	911					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				GCCTTGGCCCGAGTGCCCCTT	0.433													6	49					0	0	0	0	A	5811288	A	A	5811288	3	1	139	1	0	0	0	0	1	0	0	0	5309	1058	37	1	2806	1	EVC	4	5811288	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08		5811288	185342988	56	25005											
BOD1L	259282	broad.mit.edu	37	chr4	13606027	13606027	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctctgccttagttttttcagCtgacaagcgtctctcttttt	5	19	6	11	1	4	1	1	1	3	0	5	1	4	1	1	0	3	2	1	0	2	6	rs79874260	by1000genomes	TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:13606027C>T	uc003gmz.1	-	10	2614	c.2497G>A	c.(2497-2499)GCT>ACT	p.A833T	BOD1L_uc010idr.1_Missense_Mutation_p.A170T	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	833	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						GTTTTTTCAGCTGACAAGCGT	0.353													6	17					0	0	0	0	T	13606027	T	T	13606027	3	4	139	1	0	0	0	0	1	0	0	0	1486	797	28	4	6726	4	BOD1L	4	13606027	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	7794739	13606027	177548249	57	25006											
UBA6	55236	broad.mit.edu	37	chr4	68543386	68543386	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaaggaacagaagatgaTgtgacatgaacgtatggatt	16	10	12	3	1	0	6	0	4	0	2	0	8	0	8	0	2	2	1	0	2	5	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:68543386T>A	uc003hdg.3	-	6	460	c.408A>T	c.(406-408)ACA>ACT	p.T136T	UBA6_uc003hdi.2_Silent_p.T136T|UBA6_uc003hdj.2_Silent_p.T136T	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	136					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						CAGAAGATGATGTGACATGAA	0.308													28	38					0	0	0	0	A	68543386	A	A	68543386	2	1	139	1	0	0	0	0	0	0	0	1	16900	1451	51	5		5	UBA6	4	68543386	Silent	SNP	T	TCGA-CR-7368-01A-11D-2129-08	54937359	68543386	122610890	58	25007											
C4orf7	260436	broad.mit.edu	37	chr4	71099858	71099858	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagacgtaattttcctattcCaatacctgaatctgccccta	11	14	4	12	1	1	2	0	1	1	1	3	2	3	2	5	0	2	1	5	0	7	8			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:71099858C>T	uc003hfd.2	+	4	297	c.212C>T	c.(211-213)CCA>CTA	p.P71L		NM_152997	NP_694542	Q8NFU4	FDSCP_HUMAN	chromosome 4 open reading frame 7 precursor	71	Pro-rich.					extracellular region				central_nervous_system(1)	1						TTTCCTATTCCAATACCTGAA	0.408													42	85					0	0	0	0	T	71099858	T	T	71099858	3	4	139	1	0	0	0	0	1	0	0	0	2289	594	21	4	222	4	C4orf7	4	71099858	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	2556472	71099858	120054418	59	25008											
G3BP2	9908	broad.mit.edu	37	chr4	76572243	76572243	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcctttagctcattttcatCaatatcatgtggcaagttac	10	17	5	9	0	4	0	4	0	0	0	5	0	5	0	1	1	2	3	1	1	5	7			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:76572243C>G	uc003hir.2	-	10	1192	c.1027G>C	c.(1027-1029)GAT>CAT	p.D343H	G3BP2_uc003his.2_Missense_Mutation_p.D343H|G3BP2_uc003hit.2_Missense_Mutation_p.D310H	NM_012297	NP_036429	Q9UN86	G3BP2_HUMAN	Ras-GTPase activating protein SH3 domain-binding	343	RRM.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(2)|central_nervous_system(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TCATTTTCATCAATATCATGT	0.338													8	41					0	0	0	0	G	76572243	G	G	76572243	3	3	139	1	0	0	0	0	1	0	0	0	6176	826	29	2	433	2	G3BP2	4	76572243	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	5472385	76572243	114582033	60	25009											
PTPN13	5783	broad.mit.edu	37	chr4	87671658	87671658	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagcctgaatctccaagcaGagtctgttagaggatttaat	12	11	11	7	0	2	3	0	1	2	2	3	5	2	5	2	2	2	2	2	2	4	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:87671658G>A	uc003hpz.2	+	18	3166	c.2686G>A	c.(2686-2688)GAG>AAG	p.E896K	PTPN13_uc003hpy.2_Missense_Mutation_p.E896K|PTPN13_uc003hqa.2_Missense_Mutation_p.E896K|PTPN13_uc003hqb.2_Intron	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	896						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCTCCAAGCAGAGTCTGTTAG	0.438													9	176					0	0	0	0	A	87671658	A	A	87671658	3	1	139	1	0	0	0	0	1	0	0	0	12845	943	33	2	2752	2	PTPN13	4	87671658	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	11099415	87671658	103482618	61	25010											
RG9MTD2	93587	broad.mit.edu	37	chr4	100474995	100474995	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacataggcctttgattcatCtaattccttcagtatattag	11	16	5	9	0	3	1	2	1	1	0	4	1	4	1	2	1	0	1	2	1	5	9			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:100474995C>T	uc003huy.2	-	6	905	c.592G>A	c.(592-594)GAT>AAT	p.D198N	RG9MTD2_uc003huz.3_Missense_Mutation_p.D198N|RG9MTD2_uc003hva.3_Missense_Mutation_p.D198N	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	198							methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)		TTTGATTCATCTAATTCCTTC	0.323													6	45					0	0	0	0	T	100474995	T	T	100474995	3	4	139	1	0	0	0	0	1	0	0	0	13337	913	32	2	439	2	RG9MTD2	4	100474995	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	12803337	100474995	90679281	62	25011											
MFSD8	256471	broad.mit.edu	37	chr4	128878725	128878725	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcggctcttataatgctcttCagtctctaaaatgtcccatt	9	16	5	11	1	4	0	1	0	3	0	7	0	5	0	1	1	1	2	1	1	4	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:128878725C>G	uc003ifp.2	-	3	248	c.85G>C	c.(85-87)GAA>CAA	p.E29Q	MFSD8_uc011cgu.1_5'UTR|MFSD8_uc011cgv.1_Missense_Mutation_p.E29Q|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_5'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	29	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						TAATGCTCTTCAGTCTCTAAA	0.299													15	92					0	0	0	0	G	128878725	G	G	128878725	3	3	139	1	0	0	0	0	1	0	0	0	9591	835	29	2	1515	2	MFSD8	4	128878725	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	28403730	128878725	62275551	63	25012											
FHDC1	85462	broad.mit.edu	37	chr4	153897181	153897181	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccatcaccaagtccagcaGaggcgccggctggaggcgac	9	3	14	15	3	1	1	1	0	0	1	2	3	2	2	4	4	1	2	4	4	1	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:153897181G>A	uc003inf.2	+	11	2813	c.2738G>A	c.(2737-2739)AGA>AAA	p.R913K		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	913					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					AAGTCCAGCAGAGGCGCCGGC	0.672													5	30					0	0	0	0	A	153897181	A	A	153897181	3	1	139	1	0	0	0	0	1	0	0	0	5908	942	33	2	2780	2	FHDC1	4	153897181	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	25018456	153897181	37257095	64	25013											
DCHS2	54798	broad.mit.edu	37	chr4	155157796	155157796	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttccttgacatgggtgtgatAgctcaggctgctgaagtttg	7	14	13	7	0	1	3	1	3	0	0	2	3	2	3	1	2	2	4	1	2	2	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr4:155157796A>T	uc003inw.2	-	25	6643	c.6643T>A	c.(6643-6645)TAT>AAT	p.Y2215N		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2215	Cadherin 20.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGGTGTGATAGCTCAGGCTG	0.488													4	69					0	0	0	0	T	155157796	T	T	155157796	3	4	139	1	0	0	0	0	1	0	0	0	4305	420	15	5	2111	5	DCHS2	4	155157796	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	1260615	155157796	35996480	65	25014											
FASTKD3	79072	broad.mit.edu	37	chr5	7867461	7867461	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtaaatgtttccaatttttCaccttgaagttgatttataa	12	18	6	5	0	1	2	1	2	0	0	2	2	2	2	2	1	0	3	2	1	6	9			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:7867461C>T	uc003jeb.2	-	2	873	c.736G>A	c.(736-738)GAA>AAA	p.E246K	FASTKD3_uc011cmp.1_5'UTR|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	246					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TCCAATTTTTCACCTTGAAGT	0.373													9	119					0	0	0	0	T	7867461	T	T	7867461	3	4	139	1	0	0	0	0	1	0	0	0	5719	835	29	2	1276	2	FASTKD3	5	7867461	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08		7867461	173047799	66	25015			1	37		3	3	238	C		1.664905e-06
FASTKD3	79072	broad.mit.edu	37	chr5	7867642	7867642	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatccacatgcaacagaatCagagcttgcaaagcagtcac	15	6	9	11	0	2	2	2	0	0	2	3	3	3	3	1	1	5	4	1	1	3	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:7867642C>G	uc003jeb.2	-	2	692	c.555G>C	c.(553-555)CTG>CTC	p.L185L	FASTKD3_uc011cmp.1_Intron|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	185					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						GCAACAGAATCAGAGCTTGCA	0.433													10	127					0	0	0	0	G	7867642	G	G	7867642	2	3	139	1	0	0	0	0	0	0	0	1	5719	813	29	2		2	FASTKD3	5	7867642	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	181	7867642	173047618	67	25016			1	37		3	3	238	C		1.664905e-06
FASTKD3	79072	broad.mit.edu	37	chr5	7867698	7867698	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctgtgagggctccttttCaaactgaaagcataaagctt	12	11	9	9	0	1	2	1	2	0	0	2	2	2	2	1	1	4	4	1	1	4	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:7867698C>G	uc003jeb.2	-	2	636	c.499G>C	c.(499-501)GAA>CAA	p.E167Q	FASTKD3_uc011cmp.1_Intron|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	167					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						GGCTCCTTTTCAAACTGAAAG	0.413													8	108					0	0	0	0	G	7867698	G	G	7867698	3	3	139	1	0	0	0	0	1	0	0	0	5719	835	29	2	1513	2	FASTKD3	5	7867698	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	56	7867698	173047562	68	25017			1	37		3	3	238	C		1.664905e-06
SEMA5A	9037	broad.mit.edu	37	chr5	9052056	9052056	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggagcactggctgcccatgGggaacaggaggatgcactgg	9	5	17	10	1	0	0	0	0	0	0	0	4	0	4	1	7	4	3	1	7	1	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:9052056G>T	uc003jek.2	-	20	3486	c.2774C>A	c.(2773-2775)CCC>CAC	p.P925H		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	925	Extracellular (Potential).|TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GCTGCCCATGGGGAACAGGAG	0.572													10	32					0.000978159	0.00101017	1	0	T	9052056	T	T	9052056	3	4	139	1	0	0	0	0	1	0	0	0	14102	1232	43	4	466	4	SEMA5A	5	9052056	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1184358	9052056	171863204	69	25018											
RANBP3L	202151	broad.mit.edu	37	chr5	36251470	36251470	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcattctcatcacagctttcGcagttcaattgttgggctgt	7	16	8	10	1	4	0	4	0	1	0	6	0	4	0	0	1	1	5	0	1	1	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:36251470G>A	uc003jkh.2	-	13	1792	c.1299C>T	c.(1297-1299)TGC>TGT	p.C433C	RANBP3L_uc011cow.1_Silent_p.C458C	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	433					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CACAGCTTTCGCAGTTCAATT	0.373													19	37					0	0	0	0	A	36251470	A	A	36251470	2	1	139	1	0	0	0	0	0	0	0	1	13095	1079	38	1		1	RANBP3L	5	36251470	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	27199414	36251470	144663790	70	25019											
EGFLAM	133584	broad.mit.edu	37	chr5	38407099	38407099	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcccatacagagaaaggggaAgaatggtgtggccataatgt	14	8	13	6	0	0	2	0	0	0	2	1	4	1	3	2	4	1	0	2	4	5	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:38407099A>G	uc003jlc.1	+	8	1322	c.998A>G	c.(997-999)AAG>AGG	p.K333R	EGFLAM_uc003jlb.1_Missense_Mutation_p.K333R|EGFLAM_uc003jle.1_Missense_Mutation_p.K99R|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	333						cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					AGAAAGGGGAAGAATGGTGTG	0.532													29	106					0	0	0	0	G	38407099	G	G	38407099	3	3	139	1	0	0	0	0	1	0	0	0	4988	72	3	5	1042	5	EGFLAM	5	38407099	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	2155629	38407099	142508161	71	25020											
RICTOR	253260	broad.mit.edu	37	chr5	38944623	38944623	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctaatcttagaacttctttgCgaaggagtatacggcacatt	12	13	8	8	2	2	1	0	0	2	1	2	3	2	2	0	2	3	2	0	2	6	7			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:38944623C>T	uc003jlp.2	-	36	4862	c.4838G>A	c.(4837-4839)CGC>CAC	p.R1613H	RICTOR_uc003jlo.2_Missense_Mutation_p.R1637H|RICTOR_uc010ivf.2_Missense_Mutation_p.R1290H	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1613					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					AACTTCTTTGCGAAGGAGTAT	0.333													28	86					0	0	0	0	T	38944623	T	T	38944623	3	4	139	1	0	0	0	0	1	0	0	0	13423	768	27	1	300	1	RICTOR	5	38944623	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	537524	38944623	141970637	72	25021											
ITGA2	3673	broad.mit.edu	37	chr5	52371079	52371079	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagaagaaaacaaggctgatAatttggtcaacctcaaaatt	19	9	7	6	0	2	3	2	1	0	2	2	3	2	3	1	2	2	1	1	2	9	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:52371079A>T	uc003joy.2	+	23	2913	c.2770A>T	c.(2770-2772)AAT>TAT	p.N924Y	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.N848Y|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	924	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CAAGGCTGATAATTTGGTCAA	0.368													9	27					0	0	0	0	T	52371079	T	T	52371079	3	4	139	1	0	0	0	0	1	0	0	0	7914	362	13	5	2860	5	ITGA2	5	52371079	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	13426456	52371079	128544181	73	25022											
CCDC125	202243	broad.mit.edu	37	chr5	68616157	68616157	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaatactgaaaactcgcttCatttctttcttctccctttc	8	17	4	12	1	4	1	1	1	3	0	7	2	4	2	1	1	2	1	1	1	4	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:68616157C>G	uc003jvv.1	-	1	254	c.211G>C	c.(211-213)GAA>CAA	p.E71Q	CCDC125_uc003jvx.1_Missense_Mutation_p.E71Q|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_5'UTR|CCDC125_uc003jvz.1_Missense_Mutation_p.E71Q	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	71						cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		AAACTCGCTTCATTTCTTTCT	0.388													54	56					0	0	0	0	G	68616157	G	G	68616157	3	3	139	1	0	0	0	0	1	0	0	0	2773	835	29	2	1368	2	CCDC125	5	68616157	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	16245078	68616157	112299103	74	25023											
POLK	51426	broad.mit.edu	37	chr5	74879221	74879221	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caagctgtgatggacttcatCaaggatttacccattagaaa	14	11	8	8	0	2	2	2	1	0	1	2	4	2	4	1	2	2	1	1	2	5	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:74879221C>G	uc003kdw.2	+	8	1134	c.1038C>G	c.(1036-1038)ATC>ATG	p.I346M	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003keb.2_Missense_Mutation_p.I346M|POLK_uc010izq.2_Intron|POLK_uc003kec.2_Missense_Mutation_p.I256M|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.I256M|POLK_uc003kee.2_Missense_Mutation_p.I346M|POLK_uc003kef.2_Missense_Mutation_p.I256M	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	346	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TGGACTTCATCAAGGATTTAC	0.323								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					17	37					0	0	0	0	G	74879221	G	G	74879221	3	3	139	1	0	0	0	0	1	0	0	0	12259	816	29	2	1064	2	POLK	5	74879221	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	6263064	74879221	106036039	75	25024											
SV2C	22987	broad.mit.edu	37	chr5	75490760	75490760	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaggcagcatagtgtacctCgggatgatggtgggggcgtt	7	9	18	7	2	0	1	0	1	0	0	1	2	0	2	1	5	2	5	1	5	2	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:75490760C>T	uc003kei.1	+	3	731	c.597C>T	c.(595-597)CTC>CTT	p.L199L		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	199	Helical; (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		TAGTGTACCTCGGGATGATGG	0.468													13	125					0	0	0	0	T	75490760	T	T	75490760	2	4	139	1	0	0	0	0	0	0	0	1	15485	871	31	1		1	SV2C	5	75490760	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	611539	75490760	105424500	76	25025											
CMYA5	202333	broad.mit.edu	37	chr5	79030703	79030703	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaaagaagatagccaggaaAaaattaaactacctcctgaa	20	6	6	9	0	0	3	0	1	0	2	1	4	1	4	4	1	3	0	4	1	10	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:79030703A>G	uc003kgc.2	+	2	6187	c.6115A>G	c.(6115-6117)AAA>GAA	p.K2039E		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2039						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TAGCCAGGAAAAAATTAAACT	0.428													23	22					0	0	0	0	G	79030703	G	G	79030703	3	3	139	1	0	0	0	0	1	0	0	0	3605	15	1	5	6121	5	CMYA5	5	79030703	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	3539943	79030703	101884557	77	25026											
PCDHA2	56146	broad.mit.edu	37	chr5	140175902	140175902	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggccgacgtgaacgacaaCgcgccggcgttcgcacagcc	8	4	14	15	8	0	1	0	1	0	0	1	3	0	1	3	2	3	2	3	2	2	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:140175902C>T	uc003lhd.2	+	1	1459	c.1353C>T	c.(1351-1353)AAC>AAT	p.N451N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.N451N|PCDHA2_uc011czy.1_Silent_p.N451N	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACAACGCGCCGGCGT	0.647													39	44					0	0	0	0	T	140175902	T	T	140175902	2	4	139	1	0	0	0	0	0	0	0	1	11578	535	19	1		1	PCDHA2	5	140175902	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	61145199	140175902	40739358	78	25027											
PCDHB6	56130	broad.mit.edu	37	chr5	140529865	140529865	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaactaaagtacagaacaaGaaaaggcaagtggctttctt	18	8	8	7	0	1	2	0	0	1	2	1	2	1	2	0	2	3	3	0	2	9	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:140529865G>C	uc003lir.2	+	1	27	c.27G>C	c.(25-27)AAG>AAC	p.K9N	PCDHB6_uc011dah.1_5'UTR	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	9					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TACAGAACAAGAAAAGGCAAG	0.433													15	57					0	0	0	0	C	140529865	C	C	140529865	3	2	139	1	0	0	0	0	1	0	0	0	11600	933	33	2	29	2	PCDHB6	5	140529865	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	353963	140529865	40385395	79	25028											
PCDHGB4	8641	broad.mit.edu	37	chr5	140768638	140768638	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttaaaatattaacttcttCaagaaacacgtataaattag	19	14	3	5	1	2	1	1	0	1	1	2	1	2	1	0	0	2	1	0	0	10	9			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:140768638C>G	uc003lkc.1	+	1	1187	c.1187C>G	c.(1186-1188)TCA>TGA	p.S396*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Nonsense_Mutation_p.S396*	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	396	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAACTTCTTCAAGAAACACG	0.418													6	77					0	0	0	0	G	140768638	G	G	140768638	4	3	139	1	0	0	0	0	0	1	0	0	11619	838	29	2	1189	2	PCDHGB4	5	140768638	Nonsense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	238773	140768638	40146622	80	25029											
RNF14	9604	broad.mit.edu	37	chr5	141353158	141353158	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgttttcaggtccttatgtCgtcagaagatcgagaagctc	10	13	10	8	2	2	3	2	0	0	3	6	4	3	3	1	1	1	2	1	1	3	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:141353158C>T	uc003lly.2	+	2	44	c.5C>T	c.(4-6)TCG>TTG	p.S2L	RNF14_uc003llz.2_Missense_Mutation_p.S2L|RNF14_uc003lma.2_Missense_Mutation_p.S2L|RNF14_uc003lmb.2_5'UTR|RNF14_uc003lmc.2_Missense_Mutation_p.S2L|RNF14_uc011dbg.1_Missense_Mutation_p.S2L|RNF14_uc011dbh.1_Missense_Mutation_p.S2L|RNF14_uc003lmd.2_Missense_Mutation_p.S2L	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	2					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GTCCTTATGTCGTCAGAAGAT	0.328													8	37					0	0	0	0	T	141353158	T	T	141353158	3	4	139	1	0	0	0	0	1	0	0	0	13508	893	31	1	7	1	RNF14	5	141353158	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	584520	141353158	39562102	81	25030											
ABLIM3	22885	broad.mit.edu	37	chr5	148619423	148619423	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcatgtcccccaccttctcCcgctcacctcaccactacta	7	9	4	21	1	3	0	2	0	1	0	5	0	4	0	6	1	1	2	6	1	2	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:148619423C>T	uc003lpy.2	+	13	1427	c.1176C>T	c.(1174-1176)TCC>TCT	p.S392S	ABLIM3_uc003lpz.1_Silent_p.S392S|ABLIM3_uc003lqa.1_Silent_p.S338S|ABLIM3_uc003lqb.2_Silent_p.S330S|ABLIM3_uc003lqc.1_Silent_p.S392S|ABLIM3_uc003lqd.1_Silent_p.S330S|ABLIM3_uc003lqf.2_Silent_p.S330S|ABLIM3_uc003lqe.1_Silent_p.S330S	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	392					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCTTCTCCCGCTCACCTC	0.627													35	35					0	0	0	0	T	148619423	T	T	148619423	2	4	139	1	0	0	0	0	0	0	0	1	96	610	22	4		4	ABLIM3	5	148619423	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	7266265	148619423	32295837	82	25031											
PDGFRB	5159	broad.mit.edu	37	chr5	149516593	149516593	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgagggccagagctggcatCgcacccggaagccgcatggt	8	6	15	12	3	0	2	0	1	0	1	1	3	0	3	3	4	2	4	3	4	1	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:149516593C>T	uc003lro.2	-	2	487	c.18G>A	c.(16-18)GCG>GCA	p.A6A	PDGFRB_uc010jhd.2_5'UTR|PDGFRB_uc011dcg.1_Silent_p.A6A	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	6					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GAGCTGGCATCGCACCCGGAA	0.647			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								3	21					0	0	0	0	T	149516593	T	T	149516593	2	4	139	1	0	0	0	0	0	0	0	1	11716	871	31	1		1	PDGFRB	5	149516593	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	897170	149516593	31398667	83	25032											
GABRA1	2554	broad.mit.edu	37	chr5	161322867	161322867	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatggcaaaagtgtggttcCagaaaaggtaaatgctttaa	15	10	12	4	0	0	1	0	0	0	1	1	2	1	2	1	4	1	4	1	4	7	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:161322867C>A	uc010jiw.2	+	10	1520	c.1052C>A	c.(1051-1053)CCA>CAA	p.P351Q	GABRA1_uc010jix.2_Missense_Mutation_p.P351Q|GABRA1_uc010jiy.2_Missense_Mutation_p.P351Q|GABRA1_uc003lyx.3_Missense_Mutation_p.P351Q|GABRA1_uc010jiz.2_Missense_Mutation_p.P351Q|GABRA1_uc010jja.2_Missense_Mutation_p.P351Q|GABRA1_uc010jjb.2_Missense_Mutation_p.P351Q	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	351	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	AGTGTGGTTCCAGAAAAGGTA	0.398													31	35					4.74835e-14	5.16679e-14	1	0	A	161322867	A	A	161322867	3	1	139	1	0	0	0	0	1	0	0	0	6194	594	21	4	1082	4	GABRA1	5	161322867	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	11806274	161322867	19592393	84	25033											
BTNL9	153579	broad.mit.edu	37	chr5	180472573	180472573	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcctcatgcacctcctcctCcttcagcctggggagccgag	5	10	9	17	1	2	0	2	0	0	0	6	2	6	1	7	2	3	1	7	2	0	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr5:180472573C>T	uc003mmt.2	+	2	315	c.84C>T	c.(82-84)CTC>CTT	p.L28L	BTNL9_uc011dhi.1_Intron	NM_152547	NP_689760	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9 precursor	28						integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCTCCTCCTCCTTCAGCCTG	0.607													5	39					0	0	0	0	T	180472573	T	T	180472573	2	4	139	1	0	0	0	0	0	0	0	1	1573	842	30	2		2	BTNL9	5	180472573	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	19149706	180472573	442687	85	25034											
HIST1H2AB	8335	broad.mit.edu	37	chr6	26033738	26033738	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaactgcaaacctgcacgaGaagaccgagtcttagccttg	13	7	10	11	2	1	2	0	0	1	2	1	5	1	2	3	0	5	2	3	0	4	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:26033738G>C	uc003nft.1	-	1	59	c.59C>G	c.(58-60)TCT>TGT	p.S20C	HIST1H3B_uc003nfs.1_5'Flank	NM_003513	NP_003504	P04908	H2A1B_HUMAN	histone cluster 1, H2ab	20					nucleosome assembly	nucleosome|nucleus	DNA binding				0						ACCTGCACGAGAAGACCGAGT	0.572													5	106					0	0	0	0	C	26033738	C	C	26033738	3	2	139	1	0	0	0	0	1	0	0	0	7168	942	33	2	337	2	HIST1H2AB	6	26033738	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08		26033738	145081329	86	25035											
ZKSCAN4	387032	broad.mit.edu	37	chr6	28215883	28215883	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggaagctaccattgcatCttctctgcagcaccctccct	7	11	6	17	0	2	0	0	0	2	0	4	1	3	1	4	1	5	4	4	1	2	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:28215883C>G	uc003nks.1	-	3	860	c.616G>C	c.(616-618)GAT>CAT	p.D206H	ZKSCAN4_uc011dlb.1_Missense_Mutation_p.D51H	NM_019110	NP_061983	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	206					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						ACCATTGCATCTTCTCTGCAG	0.572													9	18					0	0	0	0	G	28215883	G	G	28215883	3	3	139	1	0	0	0	0	1	0	0	0	17756	913	32	2	1033	2	ZKSCAN4	6	28215883	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	2182145	28215883	142899184	87	25036											
NOTCH4	4855	broad.mit.edu	37	chr6	32169064	32169064	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttacccagagtcctaccctCagagtcagggacagcacccg	10	6	9	16	1	2	2	2	0	0	2	3	3	3	3	4	1	3	1	4	1	2	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:32169064C>G	uc003obb.2	-	22	4108	c.3969G>C	c.(3967-3969)CTG>CTC	p.L1323L	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1323	Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GTCCTACCCTCAGAGTCAGGG	0.642													7	67					0	0	0	0	G	32169064	G	G	32169064	2	3	139	1	0	0	0	0	0	0	0	1	10605	813	29	2		2	NOTCH4	6	32169064	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	3953181	32169064	138946003	88	25037											
SPDEF	25803	broad.mit.edu	37	chr6	34512160	34512160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccttctccaagcctgtccGcgacaccgtgtcggggggca	5	7	13	16	5	1	0	0	0	1	0	4	1	2	0	5	3	1	1	5	3	1	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:34512160G>A	uc003ojq.1	-	2	488	c.73C>T	c.(73-75)CGG>TGG	p.R25W	SPDEF_uc011dsq.1_Missense_Mutation_p.R25W	NM_012391	NP_036523	O95238	SPDEF_HUMAN	SAM pointed domain containing ets transcription	25					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(3)|ovary(1)|central_nervous_system(1)	5						AAGCCTGTCCGCGACACCGTG	0.716													5	36					0	0	0	0	A	34512160	A	A	34512160	3	1	139	1	0	0	0	0	1	0	0	0	15092	1086	38	1	954	1	SPDEF	6	34512160	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	2343096	34512160	136602907	89	25038											
PRICKLE4	29964	broad.mit.edu	37	chr6	41753185	41753185	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggcctgtggccaggccctGataaacctcatctacttcta	9	10	8	14	0	3	1	1	1	2	0	3	1	3	1	4	3	2	0	4	3	4	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:41753185G>C	uc011duf.1	+	6	737	c.489G>C	c.(487-489)CTG>CTC	p.L163L	PRICKLE4_uc003ord.2_RNA|TOMM6_uc003org.2_5'Flank|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	over-expressed breast tumor protein	123	LIM zinc-binding 1.					nucleus	zinc ion binding				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCCAGGCCCTGATAAACCTCA	0.617													5	58					0	0	0	0	C	41753185	C	C	41753185	2	2	139	1	0	0	0	0	0	0	0	1	12551	1277	45	2		2	PRICKLE4	6	41753185	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	7241025	41753185	129361882	90	25039											
PKHD1	5314	broad.mit.edu	37	chr6	51890330	51890330	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacacaagtaaaaggaccCgagaggtcaacccgaactga	17	4	9	11	2	2	2	2	1	0	1	2	5	2	3	2	2	2	1	2	2	5	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:51890330C>T	uc003pah.1	-	32	4554	c.4278G>A	c.(4276-4278)TCG>TCA	p.S1426S	PKHD1_uc003pai.2_Silent_p.S1426S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1426	IPT/TIG 9.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TAAAAGGACCCGAGAGGTCAA	0.537													28	110					0	0	0	0	T	51890330	T	T	51890330	2	4	139	1	0	0	0	0	0	0	0	1	12026	639	23	1		1	PKHD1	6	51890330	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	10137145	51890330	119224737	91	25040											
RAB23	51715	broad.mit.edu	37	chr6	57061369	57061369	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttcaaaagattccctatCtgtggtagagaacacgagca	13	10	9	9	1	2	2	1	0	1	2	3	4	3	2	1	1	3	3	1	1	5	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:57061369C>T	uc003pds.2	-	4	483	c.277G>A	c.(277-279)GAT>AAT	p.D93N	RAB23_uc003pdt.2_Missense_Mutation_p.D93N|RAB23_uc010kac.2_Missense_Mutation_p.D93N|RAB23_uc010kad.2_Intron	NM_183227	NP_899050	Q9ULC3	RAB23_HUMAN	Ras-related protein Rab-23	93					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			skin(1)	1	Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GATTCCCTATCTGTGGTAGAG	0.353													6	65					0	0	0	0	T	57061369	T	T	57061369	3	4	139	1	0	0	0	0	1	0	0	0	12975	913	32	2	452	2	RAB23	6	57061369	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	5171039	57061369	114053698	92	25041											
CD109	135228	broad.mit.edu	37	chr6	74516607	74516607	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatgtttccttgaagccgatCcttacatagatattgatcag	11	14	8	8	1	1	3	1	2	0	1	3	5	3	3	3	0	2	1	3	0	4	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:74516607C>G	uc003php.2	+	25	3426	c.3001C>G	c.(3001-3003)CCT>GCT	p.P1001A	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Missense_Mutation_p.P1001A|CD109_uc010kba.2_Missense_Mutation_p.P924A	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	1001						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						TGAAGCCGATCCTTACATAGA	0.343													4	30					0	0	0	0	G	74516607	G	G	74516607	3	3	139	1	0	0	0	0	1	0	0	0	2978	855	30	2	3099	2	CD109	6	74516607	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	17455238	74516607	96598460	93	25042											
ZNF292	23036	broad.mit.edu	37	chr6	87969609	87969609	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agattaggaggcataaaaaaGaaaaggaggagaaaaaacga	24	3	12	2	1	0	3	0	0	0	3	0	7	0	5	0	4	1	1	0	4	9	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:87969609G>C	uc003plm.3	+	8	6303	c.6262G>C	c.(6262-6264)GAA>CAA	p.E2088Q		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2088					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GCATAAAAAAGAAAAGGAGGA	0.388													7	45					0	0	0	0	C	87969609	C	C	87969609	3	2	139	1	0	0	0	0	1	0	0	0	17893	943	33	2	6292	2	ZNF292	6	87969609	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	13453002	87969609	83145458	94	25043											
CNR1	1268	broad.mit.edu	37	chr6	88853849	88853849	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagcaggcagagcatactgCagaatgcaaacaccgtctta	14	7	9	11	1	2	2	1	0	1	2	2	2	2	2	1	1	6	5	1	1	4	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:88853849C>A	uc011dzq.1	-	2	4708	c.1145G>T	c.(1144-1146)TGC>TTC	p.C382F	CNR1_uc010kbz.2_Missense_Mutation_p.C382F|CNR1_uc011dzr.1_Missense_Mutation_p.C382F|CNR1_uc011dzs.1_Missense_Mutation_p.C382F|CNR1_uc003pmq.3_Missense_Mutation_p.C382F|CNR1_uc011dzt.1_Missense_Mutation_p.C382F|CNR1_uc010kca.2_Missense_Mutation_p.C349F	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	382	Helical; Name=7; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GAGCATACTGCAGAATGCAAA	0.507													18	49					3.51602e-12	3.81125e-12	1	0	A	88853849	A	A	88853849	3	1	139	1	0	0	0	0	1	0	0	0	3646	710	25	4	277	4	CNR1	6	88853849	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	884240	88853849	82261218	95	25044											
PREP	5550	broad.mit.edu	37	chr6	105824004	105824004	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tctgtgtagcacttacctcgGagtgccactgtgccatcgtc	6	12	10	13	2	1	0	0	0	1	0	4	1	1	1	3	1	4	2	3	1	2	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:105824004G>C	uc003prc.2	-	4	584	c.381C>G	c.(379-381)CTC>CTG	p.L127L		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	127					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	ACTTACCTCGGAGTGCCACTG	0.522													17	38					0	0	0	0	C	105824004	C	C	105824004	2	2	139	1	0	0	0	0	0	0	0	1	12536	1161	41	2		2	PREP	6	105824004	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	16970155	105824004	65291063	96	25045											
REV3L	5980	broad.mit.edu	37	chr6	111697577	111697577	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaatatcttcttcataatCaaaaatactactttcacagg	15	14	4	8	0	5	0	3	0	2	0	5	1	5	1	0	2	2	0	0	2	7	7			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:111697577C>T	uc003puy.3	-	13	2304	c.1981G>A	c.(1981-1983)GAT>AAT	p.D661N	REV3L_uc003pux.3_Missense_Mutation_p.D583N|REV3L_uc003puz.3_Missense_Mutation_p.D583N	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	661					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TCTTCATAATCAAAAATACTA	0.323								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					15	38					0	0	0	0	T	111697577	T	T	111697577	3	4	139	1	0	0	0	0	1	0	0	0	13305	826	29	2	7491	2	REV3L	6	111697577	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	5873573	111697577	59417490	97	25046											
FYN	2534	broad.mit.edu	37	chr6	112035585	112035585	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaatttttctcctttgtgAaaactcaggtcatcttctgt	9	18	6	8	0	5	2	2	2	3	0	6	2	5	2	1	1	1	0	1	1	3	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:112035585A>T	uc003pvj.2	-	4	649	c.309T>A	c.(307-309)TTT>TTA	p.F103L	FYN_uc003pvi.2_Missense_Mutation_p.F103L|FYN_uc003pvk.2_Missense_Mutation_p.F103L|FYN_uc003pvh.2_Missense_Mutation_p.F103L	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	103	SH3.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	CTCCTTTGTGAAAACTCAGGT	0.428													5	58					0	0	0	0	T	112035585	T	T	112035585	3	4	139	1	0	0	0	0	1	0	0	0	6160	243	9	5	1504	5	FYN	6	112035585	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	338008	112035585	59079482	98	25047											
HS3ST5	222537	broad.mit.edu	37	chr6	114378934	114378934	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgacaatgatcaacaacttGatggatgagttcattttgta	13	14	8	6	0	2	4	2	4	0	0	2	5	2	5	0	1	2	2	0	1	4	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:114378934G>A	uc003pwg.3	-	2	560	c.528C>T	c.(526-528)ATC>ATT	p.I176I	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Silent_p.I176I	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	176	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		TCAACAACTTGATGGATGAGT	0.403													43	247					0	0	0	0	A	114378934	A	A	114378934	2	1	139	1	0	0	0	0	0	0	0	1	7407	1280	45	2		2	HS3ST5	6	114378934	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	2343349	114378934	56736133	99	25048											
SYNE1	23345	broad.mit.edu	37	chr6	152770688	152770688	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaacggcacgtttaacctCtccgtggttggcagtatcga	8	12	10	11	4	2	0	1	0	1	0	4	1	2	0	2	3	2	5	2	3	3	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr6:152770688C>G	uc010kiw.2	-	28	4086	c.3484G>C	c.(3484-3486)GAG>CAG	p.E1162Q	SYNE1_uc003qot.3_Missense_Mutation_p.E1169Q|SYNE1_uc003qou.3_Missense_Mutation_p.E1162Q|SYNE1_uc010kjb.1_Missense_Mutation_p.E1145Q|SYNE1_uc003qow.2_Missense_Mutation_p.E457Q|SYNE1_uc003qox.1_Missense_Mutation_p.E678Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1162	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CGTTTAACCTCTCCGTGGTTG	0.403										HNSCC(10;0.0054)			25	46					0	0	0	0	G	152770688	G	G	152770688	3	3	139	1	0	0	0	0	1	0	0	0	15511	922	32	2	23458	2	SYNE1	6	152770688	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	38391754	152770688	18344379	100	25049											
DMTF1	9988	broad.mit.edu	37	chr7	86817567	86817567	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagataatacagccatctCttctagccccatggcagcat	12	9	8	12	0	2	1	0	0	2	1	3	2	2	2	3	2	4	2	3	2	4	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:86817567C>T	uc003uih.2	+	13	1687	c.1361C>T	c.(1360-1362)TCT>TTT	p.S454F	DMTF1_uc003uii.2_Missense_Mutation_p.S188F|DMTF1_uc003uij.2_Missense_Mutation_p.S188F|DMTF1_uc011khb.1_Missense_Mutation_p.S366F|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Missense_Mutation_p.S454F|DMTF1_uc003uin.2_Missense_Mutation_p.S188F	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	454	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					ACAGCCATCTCTTCTAGCCCC	0.423													56	114					0	0	0	0	T	86817567	T	T	86817567	3	4	139	1	0	0	0	0	1	0	0	0	4614	913	32	2	1403	2	DMTF1	7	86817567	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08		86817567	72321096	101	25050											
RUNDC3B	154661	broad.mit.edu	37	chr7	87339931	87339931	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatggaaaaacatttatctGaatacatctctacagctctg	14	13	5	9	0	4	1	1	1	3	0	5	2	4	2	0	1	4	1	0	1	6	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:87339931G>C	uc003ujb.2	+	5	880	c.469G>C	c.(469-471)GAA>CAA	p.E157Q	ABCB1_uc003uiz.1_Intron|ABCB1_uc003uja.1_Intron|ABCB1_uc010lei.1_Intron|RUNDC3B_uc011khd.1_Missense_Mutation_p.E140Q|RUNDC3B_uc011khe.1_Missense_Mutation_p.E140Q|RUNDC3B_uc003ujc.2_Missense_Mutation_p.E140Q|RUNDC3B_uc003ujd.2_Missense_Mutation_p.E62Q	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	157	RUN.									skin(1)	1	Esophageal squamous(14;0.00164)					ACATTTATCTGAATACATCTC	0.303													14	29					0	0	0	0	C	87339931	C	C	87339931	3	2	139	1	0	0	0	0	1	0	0	0	13810	1291	45	2	487	2	RUNDC3B	7	87339931	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	522364	87339931	71798732	102	25051											
MGC26647	219557	broad.mit.edu	37	chr7	88424117	88424117	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccactagaaacatcctatcaAgaaggaatttctttaggtgt	14	12	7	8	0	2	2	1	0	1	2	3	3	3	3	2	2	1	0	2	2	7	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:88424117A>T	uc003ujv.2	-	2	322	c.140T>A	c.(139-141)CTT>CAT	p.L47H	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	47											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			CATCCTATCAAGAAGGAATTT	0.388													40	97					0	0	0	0	T	88424117	T	T	88424117	3	4	139	1	0	0	0	0	1	0	0	0	9603	72	3	5	625	5	MGC26647	7	88424117	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	1084186	88424117	70714546	103	25052											
COL1A2	1278	broad.mit.edu	37	chr7	94043559	94043559	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctggcccctcaggtcccgCtggtgaagttggcaaaccag	7	7	13	14	1	1	1	1	1	0	0	2	1	2	1	5	4	1	3	5	4	2	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:94043559C>A	uc003ung.1	+	29	2162	c.1691C>A	c.(1690-1692)GCT>GAT	p.A564D	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	564					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCAGGTCCCGCTGGTGAAGTT	0.433										HNSCC(75;0.22)			7	33					3.09899e-07	3.284e-07	1	0	A	94043559	A	A	94043559	3	1	139	1	0	0	0	0	1	0	0	0	3693	797	28	4	1805	4	COL1A2	7	94043559	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	5619442	94043559	65095104	104	25053											
NPTX2	4885	broad.mit.edu	37	chr7	98256519	98256519	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgacggcaagtggcacCacatctgtgtcacctggacg	9	8	12	12	2	3	1	2	1	1	0	3	2	3	2	2	3	0	2	2	3	1	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:98256519C>T	uc003upl.2	+	4	1108	c.931C>T	c.(931-933)CAC>TAC	p.H311Y		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	311	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			CAAGTGGCACCACATCTGTGT	0.637													19	30					0	0	0	0	T	98256519	T	T	98256519	3	4	139	1	0	0	0	0	1	0	0	0	10657	594	21	4	945	4	NPTX2	7	98256519	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	4212960	98256519	60882144	105	25054											
SLC26A5	375611	broad.mit.edu	37	chr7	103017279	103017279	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcatcctgctaagtatacatAtataccgacgtctccatatt	12	13	5	11	2	1	0	0	0	1	0	3	1	2	0	3	0	3	3	3	0	7	8			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:103017279A>G	uc003vbz.2	-	19	2253	c.2017T>C	c.(2017-2019)TAT>CAT	p.Y673H	SLC26A5_uc003vbt.1_Missense_Mutation_p.Y673H|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.Y641H|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	673	Cytoplasmic (Potential).|STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						AAGTATACATATATACCGACG	0.313													14	58					0	0	0	0	G	103017279	G	G	103017279	3	3	139	1	0	0	0	0	1	0	0	0	14584	449	16	5	266	5	SLC26A5	7	103017279	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	4760760	103017279	56121384	106	25055											
RINT1	60561	broad.mit.edu	37	chr7	105190824	105190834	+	Frame_Shift_Del	DEL	TGAAAGGGAGC	-	-																															gtggatgaagtactcttgttTgaaagggagctacacagtgt																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:105190824_105190834delTGAAAGGGAGC	uc003vda.1	+	9	1455_1465	c.1224_1234delTGAAAGGGAGC	c.(1222-1236)TTTGAAAGGGAGCTAfs	p.F408fs	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	408_412	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						TACTCTTGTTTGAAAGGGAGCTACACAGTGT	0.417													---	---	---								-	105190834	-	-	105190824	7	5	139	1	0	1	0	1	0	0	0	0	13441	1809	63	0	1258	0	RINT1	7	105190824	Frame_Shift_Del	DEL	TGAAAGGGAGC	TCGA-CR-7368-01A-11D-2129-08	2173545	105190824	53947839	107	25056											
CTTNBP2	83992	broad.mit.edu	37	chr7	117431659	117431659	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactcgtgctacaccatgagTctttaaactggtccgaccaa	12	10	7	12	2	1	1	0	1	1	0	3	2	2	1	3	1	4	1	3	1	5	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:117431659T>A	uc003vjf.2	-	4	1683	c.1591A>T	c.(1591-1593)ACT>TCT	p.T531S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	531	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		ACACCATGAGTCTTTAAACTG	0.547													42	79					0	0	0	0	A	117431659	A	A	117431659	3	1	139	1	0	0	0	0	1	0	0	0	4062	1667	58	5	3480	5	CTTNBP2	7	117431659	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08	12240835	117431659	41707004	108	25057											
RBM28	55131	broad.mit.edu	37	chr7	127964661	127964661	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccagtcggcttcttcacCttcgtcgtctgaagctttgc	4	14	10	13	3	3	1	1	1	2	0	6	1	3	1	2	1	3	2	2	1	1	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:127964661C>G	uc003vmp.2	-	12	1405	c.1290G>C	c.(1288-1290)AAG>AAC	p.K430N	RBM28_uc003vmo.2_Missense_Mutation_p.K47N|RBM28_uc011koj.1_Missense_Mutation_p.K289N|RBM28_uc011kok.1_Missense_Mutation_p.K377N	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	430					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						GCTTCTTCACCTTCGTCGTCT	0.557													26	207					0	0	0	0	G	127964661	G	G	127964661	3	3	139	1	0	0	0	0	1	0	0	0	13193	680	24	4	1021	4	RBM28	7	127964661	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	10533002	127964661	31174002	109	25058											
AHCYL2	23382	broad.mit.edu	37	chr7	129028933	129028933	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagctctgatgatgagacatCgcccagggacaagcagcaaa	14	6	11	10	1	1	3	0	3	1	1	2	5	1	4	1	1	3	3	1	1	3	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:129028933C>T	uc011kov.1	+	3	566	c.512C>T	c.(511-513)TCG>TTG	p.S171L	AHCYL2_uc003vot.2_Missense_Mutation_p.S170L|AHCYL2_uc003vov.2_Missense_Mutation_p.S68L|AHCYL2_uc011kow.1_Missense_Mutation_p.S69L|AHCYL2_uc011kox.1_Missense_Mutation_p.S68L	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	171					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						GATGAGACATCGCCCAGGGAC	0.398													19	49					0	0	0	0	T	129028933	T	T	129028933	3	4	139	1	0	0	0	0	1	0	0	0	411	893	31	1	644	1	AHCYL2	7	129028933	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	1064272	129028933	30109730	110	25059											
ZC3HAV1	56829	broad.mit.edu	37	chr7	138774437	138774437	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctttgttcagtccagagAgttcgtgatttttcaggact	7	16	9	9	1	3	2	2	1	1	1	5	4	4	3	2	1	0	2	2	1	0	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr7:138774437A>T	uc003vun.2	-	2	765	c.377T>A	c.(376-378)CTC>CAC	p.L126H	ZC3HAV1_uc003vup.2_Missense_Mutation_p.L126H	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	126					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						CAGTCCAGAGAGTTCGTGATT	0.408													26	11					0	0	0	0	T	138774437	T	T	138774437	3	4	139	1	0	0	0	0	1	0	0	0	17642	304	11	5	2383	5	ZC3HAV1	7	138774437	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	9745504	138774437	20364226	111	25060											
MTMR9	66036	broad.mit.edu	37	chr8	11172549	11172549	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accattcgtggttttgaggcCctgattgaaagagagtggct	9	12	13	7	1	0	4	0	3	0	1	1	5	0	4	2	3	0	2	2	3	1	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:11172549C>T	uc003wtm.2	+	7	1487	c.1089C>T	c.(1087-1089)GCC>GCT	p.A363A	MTMR9_uc010lrx.2_Silent_p.A256A|MTMR9_uc011kxa.1_Silent_p.A278A	NM_015458	NP_056273	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	363	Myotubularin phosphatase.					cytoplasm	phosphatase activity|protein binding				0			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		GTTTTGAGGCCCTGATTGAAA	0.483													48	114					0	0	0	0	T	11172549	T	T	11172549	2	4	139	1	0	0	0	0	0	0	0	1	10003	610	22	4		4	MTMR9	8	11172549	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08		11172549	135191473	112	25061											
BIN3	55909	broad.mit.edu	37	chr8	22487967	22487967	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagtcaccttttcctgattGaaggcatccatccgcttcat	8	14	6	13	1	2	2	2	2	0	0	5	2	5	2	4	1	0	2	4	1	2	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:22487967G>T	uc003xcl.2	-	5	382	c.285C>A	c.(283-285)TTC>TTA	p.F95L	BIN3_uc003xck.2_Missense_Mutation_p.F47L|BIN3_uc010ltw.2_Missense_Mutation_p.F41L	NM_018688	NP_061158	Q9NQY0	BIN3_HUMAN	bridging integrator 3	95	BAR.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity				0		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		TTTCCTGATTGAAGGCATCCA	0.592													36	186					3.61848e-18	3.96775e-18	1	0	T	22487967	T	T	22487967	3	4	139	1	0	0	0	0	1	0	0	0	1437	1281	45	2	496	2	BIN3	8	22487967	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	11315418	22487967	123876055	113	25062											
NEFM	4741	broad.mit.edu	37	chr8	24771655	24771655	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgctttgccggctacataGagaaggtgcactacctggag	10	8	12	11	2	0	1	0	0	0	1	0	3	0	2	3	3	4	3	3	3	4	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:24771655G>C	uc003xed.3	+	1	382	c.349G>C	c.(349-351)GAG>CAG	p.E117Q	NEFM_uc011lac.1_Missense_Mutation_p.E117Q|NEFM_uc010lue.2_5'Flank|uc010luc.1_3'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	117	Rod.|Coil 1A.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CGGCTACATAGAGAAGGTGCA	0.647													3	13					0	0	0	0	C	24771655	C	C	24771655	3	2	139	1	0	0	0	0	1	0	0	0	10370	943	33	2	351	2	NEFM	8	24771655	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	2283688	24771655	121592367	114	25063											
DCTN6	10671	broad.mit.edu	37	chr8	30038087	30038087	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacatttgaagtcatccctGagaatacggtgatctatggt	12	13	9	7	1	2	3	1	3	1	1	3	4	3	3	1	2	2	0	1	2	5	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:30038087G>C	uc003xhy.2	+	6	502	c.415G>C	c.(415-417)GAG>CAG	p.E139Q		NM_006571	NP_006562	O00399	DCTN6_HUMAN	dynactin 6	139						centrosome	transferase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.099)|Kidney(114;0.119)		AGTCATCCCTGAGAATACGGT	0.438													10	43					0	0	0	0	C	30038087	C	C	30038087	3	2	139	1	0	0	0	0	1	0	0	0	4328	1291	45	2	437	2	DCTN6	8	30038087	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	5266432	30038087	116325935	115	25064											
RBPMS	11030	broad.mit.edu	37	chr8	30402106	30402106	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tagcgcctgctctacctcctCctgctttcacctatcccgct	4	13	5	19	2	2	0	1	0	1	0	5	0	5	0	6	0	4	3	6	0	3	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:30402106C>G	uc003xic.1	+	6	1158	c.493C>G	c.(493-495)CCT>GCT	p.P165A	RBPMS_uc003xid.1_Missense_Mutation_p.P165A|RBPMS_uc003xie.1_Missense_Mutation_p.P165A|RBPMS_uc003xif.1_RNA|RBPMS_uc011lba.1_Missense_Mutation_p.P165A|RBPMS_uc003xib.2_Missense_Mutation_p.P165A|RBPMS_uc010lvh.1_Missense_Mutation_p.P61A	NM_006867	NP_006858	Q93062	RBPMS_HUMAN	RNA-binding protein with multiple splicing	165					positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|nucleus	nucleotide binding|poly(A) RNA binding|protein binding|transcription coactivator activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.144)|Kidney(114;0.172)		TCTACCTCCTCCTGCTTTCAC	0.562													8	159					0	0	0	0	G	30402106	G	G	30402106	3	3	139	1	0	0	0	0	1	0	0	0	13228	855	30	2	515	2	RBPMS	8	30402106	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	364019	30402106	115961916	116	25065											
PURG	29942	broad.mit.edu	37	chr8	30889927	30889927	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcccaggtgggcatagtgCtcgatgaagtcccctagaca	10	7	13	11	1	0	2	0	1	0	1	2	3	1	2	3	3	1	2	3	3	3	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:30889927C>T	uc003xin.2	-	1	391	c.372G>A	c.(370-372)GAG>GAA	p.E124E	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Silent_p.E124E	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	124	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		GGGCATAGTGCTCGATGAAGT	0.597													15	92					0	0	0	0	T	30889927	T	T	30889927	2	4	139	1	0	0	0	0	0	0	0	1	12894	796	28	4		4	PURG	8	30889927	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	487821	30889927	115474095	117	25066											
RB1CC1	9821	broad.mit.edu	37	chr8	53569790	53569790	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcattttttaaagacagtaGttctttttgatgtttttctt	8	24	5	4	0	3	2	1	1	2	1	3	2	3	2	0	0	0	3	0	0	3	11			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:53569790G>C	uc003xre.3	-	15	3157	c.2599C>G	c.(2599-2601)CTA>GTA	p.L867V	RB1CC1_uc003xrf.3_Missense_Mutation_p.L867V	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	867	Potential.				autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AAAGACAGTAGTTCTTTTTGA	0.264													7	33					0	0	0	0	C	53569790	C	C	53569790	3	2	139	1	0	0	0	0	1	0	0	0	13164	1020	36	4	2225	4	RB1CC1	8	53569790	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	22679863	53569790	92794232	118	25067											
MOS	4342	broad.mit.edu	37	chr8	57025630	57025630	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcccggggagcgagtcctcGaagacggcagcggagaggga	9	3	19	10	5	0	2	0	0	0	2	2	7	1	4	2	5	3	1	2	5	1	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:57025630G>A	uc011leb.1	-	1	912	c.912C>T	c.(910-912)TTC>TTT	p.F304F		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	304	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			GCGAGTCCTCGAAGACGGCAG	0.682													6	29					0	0	0	0	A	57025630	A	A	57025630	2	1	139	1	0	0	0	0	0	0	0	1	9765	1049	37	1		1	MOS	8	57025630	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	3455840	57025630	89338392	119	25068											
CSPP1	79848	broad.mit.edu	37	chr8	68028195	68028195	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaccaagacactttgaagAgatgataccacctgaaagac	16	6	9	10	0	0	6	0	3	0	3	0	7	0	6	3	1	1	1	3	1	4	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:68028195A>G	uc003xxi.2	+	13	1455	c.1424A>G	c.(1423-1425)GAG>GGG	p.E475G	CSPP1_uc003xxg.1_Missense_Mutation_p.E467G|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.E440G|CSPP1_uc003xxk.2_Missense_Mutation_p.E146G	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	475						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			CACTTTGAAGAGATGATACCA	0.408													37	81					0	0	0	0	G	68028195	G	G	68028195	3	3	139	1	0	0	0	0	1	0	0	0	3979	304	11	5	1474	5	CSPP1	8	68028195	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	11002565	68028195	78335827	120	25069											
KIAA1429	25962	broad.mit.edu	37	chr8	95504890	95504890	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaattttaccttgacgttaTaaaggtctcatgcttgtgct	10	17	7	7	1	1	1	1	1	1	0	2	1	1	1	1	1	3	3	1	1	6	7			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr8:95504890T>C	uc003ygo.1	-	21	4811	c.4798A>G	c.(4798-4800)ATA>GTA	p.I1600V	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1600					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CTTGACGTTATAAAGGTCTCA	0.338													10	74					0	0	0	0	C	95504890	C	C	95504890	3	2	139	1	0	0	0	0	1	0	0	0	8270	1406	49	5	656	5	KIAA1429	8	95504890	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08	27476695	95504890	50859132	121	25070											
IFNA8	3445	broad.mit.edu	37	chr9	21409512	21409512	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaattctacatcgaacttGaccagcagctgaatgacctg	13	10	8	10	1	1	4	0	4	1	0	2	5	1	4	2	0	4	2	2	0	4	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:21409512G>C	uc003zpc.1	+	1	367	c.337G>C	c.(337-339)GAC>CAC	p.D113H		NM_002170	NP_002161	P32881	IFNA8_HUMAN	interferon, alpha 8 precursor	113					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		CATCGAACTTGACCAGCAGCT	0.502													26	45					0	0	0	0	C	21409512	C	C	21409512	3	2	139	1	0	0	0	0	1	0	0	0	7582	1290	45	2	339	2	IFNA8	9	21409512	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08		21409512	119803919	122	25071											
RGP1	9827	broad.mit.edu	37	chr9	35751957	35751957	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtctcttgctcccagttttCagtcagcttacagaccgagg	7	13	9	12	1	3	1	2	0	1	1	5	2	4	1	2	1	3	3	2	1	1	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:35751957C>T	uc011lpf.1	+	8	908	c.767C>T	c.(766-768)TCA>TTA	p.S256L	GBA2_uc003zxw.2_5'Flank|GBA2_uc011lpc.1_5'Flank|GBA2_uc011lpd.1_5'Flank|RGP1_uc011lpe.1_Missense_Mutation_p.S296L	NM_001080496	NP_001073965	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog	256										ovary(1)	1	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCCCAGTTTTCAGTCAGCTTA	0.577													5	24					0	0	0	0	T	35751957	T	T	35751957	3	4	139	1	0	0	0	0	1	0	0	0	13349	838	29	2	921	2	RGP1	9	35751957	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	14342445	35751957	105461474	123	25072											
CBWD6	644019	broad.mit.edu	37	chr9	69238279	69238279	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcttctgggaccaagtctgTtttattaatgagaatgatat	11	17	8	5	0	3	2	0	2	3	1	3	4	3	3	1	1	0	1	1	1	5	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:69238279T>C	uc004afj.3	-	8	719	c.613A>G	c.(613-615)ACA>GCA	p.T205A	CBWD6_uc004afk.3_Intron|CBWD6_uc011lrf.1_Intron	NM_001085457	NP_001078926	Q4V339	CBWD6_HUMAN	COBW domain containing 6	205	ATP (Potential).						ATP binding				0						ACCAAGTCTGTTTTATTAATG	0.313													35	110					0	0	0	0	C	69238279	C	C	69238279	3	2	139	1	0	0	0	0	1	0	0	0	2728	1725	60	5	606	5	CBWD6	9	69238279	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08	33486322	69238279	71975152	124	25073											
PIP5K1B	8395	broad.mit.edu	37	chr9	71606110	71606110	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagaggggaccatctacttGaccgctgagcccaacactct	11	7	10	13	1	2	3	0	2	2	1	2	5	2	4	3	2	3	1	3	2	3	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:71606110G>A	uc004agu.2	+	15	1862	c.1557G>A	c.(1555-1557)TTG>TTA	p.L519L	PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	519						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		CCATCTACTTGACCGCTGAGC	0.448													9	95					0	0	0	0	A	71606110	A	A	71606110	2	1	139	1	0	0	0	0	0	0	0	1	11995	1281	45	2		2	PIP5K1B	9	71606110	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	2367831	71606110	69607321	125	25074											
FAM120A	23196	broad.mit.edu	37	chr9	96291798	96291798	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtcgcacctgaggtgctgaGagtggccgagcacaggcaca	9	5	15	12	3	0	2	0	2	0	1	1	4	0	2	2	3	2	4	2	3	0	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:96291798G>C	uc004atw.2	+	9	1695	c.1670G>C	c.(1669-1671)AGA>ACA	p.R557T	FAM120A_uc004atv.2_Missense_Mutation_p.R557T|FAM120A_uc004atx.2_Missense_Mutation_p.R339T|FAM120A_uc004aty.2_Missense_Mutation_p.R338T|FAM120A_uc004atz.2_Missense_Mutation_p.R206T|FAM120A_uc010mrf.1_RNA|FAM120A_uc010mrg.2_5'Flank	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	557						cytoplasm|plasma membrane	RNA binding				0						GAGGTGCTGAGAGTGGCCGAG	0.592													15	65					0	0	0	0	C	96291798	C	C	96291798	3	2	139	1	0	0	0	0	1	0	0	0	5443	942	33	2	1704	2	FAM120A	9	96291798	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	24685688	96291798	44921633	126	25075											
FAM120A	23196	broad.mit.edu	37	chr9	96320925	96320925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcccttaccgtgccttcCgtgtggcggcagcatcggga	5	8	14	14	4	0	0	0	0	0	0	2	1	1	1	4	4	3	2	4	4	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:96320925C>T	uc004atw.2	+	15	2756	c.2731C>T	c.(2731-2733)CGT>TGT	p.R911C	FAM120A_uc004aty.2_Missense_Mutation_p.R692C|FAM120A_uc004atz.2_Missense_Mutation_p.R560C|FAM120A_uc010mrg.2_Intron	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	911	RNA binding.					cytoplasm|plasma membrane	RNA binding				0						CCGTGCCTTCCGTGTGGCGGC	0.612													18	96					0	0	0	0	T	96320925	T	T	96320925	3	4	139	1	0	0	0	0	1	0	0	0	5443	652	23	1	2789	1	FAM120A	9	96320925	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	29127	96320925	44892506	127	25076											
RBM18	92400	broad.mit.edu	37	chr9	125004258	125004258	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacaggcgctgctggatactCtgcatcaggattttccgcca	9	10	10	12	2	2	0	1	0	1	0	3	2	3	2	2	3	4	3	2	3	2	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:125004258C>G	uc004bma.2	-	6	644	c.478G>C	c.(478-480)GAG>CAG	p.E160Q	RBM18_uc004blz.2_RNA|RBM18_uc010mvy.2_RNA|RBM18_uc011lyp.1_RNA	NM_033117	NP_149108	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	160							nucleotide binding|RNA binding				0						GCTGGATACTCTGCATCAGGA	0.408													13	78					0	0	0	0	G	125004258	G	G	125004258	3	3	139	1	0	0	0	0	1	0	0	0	13185	922	32	2	98	2	RBM18	9	125004258	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	28683333	125004258	16209173	128	25077											
COL5A1	1289	broad.mit.edu	37	chr9	137623932	137623932	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccagattggaggacctcggGgcgagaaaggccaaaaggga	13	3	16	9	2	0	2	0	0	0	2	1	6	0	5	3	6	0	0	3	6	3	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:137623932G>T	uc004cfe.2	+	9	1730	c.1348G>T	c.(1348-1350)GGC>TGC	p.G450C		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	450	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGGACCTCGGGGCGAGAAAGG	0.527													67	56					7.07328e-35	7.84692e-35	1	0	T	137623932	T	T	137623932	3	4	139	1	0	0	0	0	1	0	0	0	3711	1232	43	4	1382	4	COL5A1	9	137623932	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	12619674	137623932	3589499	129	25078											
MAMDC4	158056	broad.mit.edu	37	chr9	139751179	139751179	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaggtctcctgtaactttGagcgggacacatgcagctgg	9	9	13	10	1	1	2	0	1	1	1	2	3	1	3	1	3	4	3	1	3	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr9:139751179G>A	uc004cjs.2	+	15	1788	c.1738G>A	c.(1738-1740)GAG>AAG	p.E580K	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	659	MAM 4.|Extracellular (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CTGTAACTTTGAGCGGGACAC	0.662													10	23					0	0	0	0	A	139751179	A	A	139751179	3	1	139	1	0	0	0	0	1	0	0	0	9257	1291	45	2	1796	2	MAMDC4	9	139751179	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	2127247	139751179	1462252	130	25079											
FBXO18	84893	broad.mit.edu	37	chr10	5956205	5956205	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacaagatggaacctctcCaggtggtgaaaattatggcc	13	9	10	9	0	2	2	1	1	1	1	3	3	2	3	3	4	1	0	3	4	5	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:5956205C>T	uc001iis.2	+	8	1464	c.1369C>T	c.(1369-1371)CAG>TAG	p.Q457*	FBXO18_uc001iir.2_Nonsense_Mutation_p.Q383*|FBXO18_uc009xig.2_Nonsense_Mutation_p.Q383*|FBXO18_uc001iit.2_Nonsense_Mutation_p.Q508*	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	457					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						GGAACCTCTCCAGGTGGTGAA	0.448													9	86					0	0	0	0	T	5956205	T	T	5956205	4	4	139	1	0	0	0	0	0	1	0	0	5763	595	21	4	1561	4	FBXO18	10	5956205	Nonsense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08		5956205	129578542	131	25080											
APBB1IP	54518	broad.mit.edu	37	chr10	26789781	26789781	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggaagaccaagatttagAtgctctcatggcagatctgg	12	10	11	8	0	2	4	1	0	2	4	3	5	2	5	1	3	1	2	1	3	3	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:26789781A>G	uc001iss.2	+	5	515	c.194A>G	c.(193-195)GAT>GGT	p.D65G	APBB1IP_uc001isr.2_Missense_Mutation_p.D65G|APBB1IP_uc009xks.1_Missense_Mutation_p.D65G	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	65					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CAAGATTTAGATGCTCTCATG	0.403													14	51					0	0	0	0	G	26789781	G	G	26789781	3	3	139	1	0	0	0	0	1	0	0	0	760	333	12	5	204	5	APBB1IP	10	26789781	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	20833576	26789781	108744966	132	25081											
MASTL	84930	broad.mit.edu	37	chr10	27459563	27459563	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttttctatgttctgatgatGatagagcttctaaaaatatt	12	18	7	4	0	3	4	0	3	3	1	3	4	3	4	0	0	1	3	0	0	6	9			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:27459563G>A	uc001itm.2	+	8	2314	c.1675G>A	c.(1675-1677)GAT>AAT	p.D559N	MASTL_uc001itl.2_Missense_Mutation_p.D559N|MASTL_uc009xkw.1_Missense_Mutation_p.D559N|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	559	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						TTCTGATGATGATAGAGCTTC	0.333													14	51					0	0	0	0	A	27459563	A	A	27459563	3	1	139	1	0	0	0	0	1	0	0	0	9381	1290	45	2	1705	2	MASTL	10	27459563	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	669782	27459563	108075184	133	25082											
ITGB1	3688	broad.mit.edu	37	chr10	33197461	33197462	+	Frame_Shift_Del	DEL	CT	-	-																															atgtctggaccagtgggacaCtctggaaaataagaaggtaa																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:33197461_33197462delCT	uc001iws.3	-	15	2301_2302	c.2165_2166delAG	c.(2164-2166)GAGfs	p.E722fs	ITGB1_uc001iwp.3_Frame_Shift_Del_p.E722fs|ITGB1_uc001iwq.3_Frame_Shift_Del_p.E722fs|ITGB1_uc001iwr.3_Frame_Shift_Del_p.E722fs|ITGB1_uc001iwt.3_Frame_Shift_Del_p.E722fs|ITGB1_uc001iwu.1_Frame_Shift_Del_p.E722fs	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	722	Extracellular (Potential).				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				CAGTGGGACACTCTGGAAAATA	0.406													---	---	---								-	33197462	-	-	33197461	7	5	139	1	0	1	0	1	0	0	0	0	7929	579	20	0	476	0	ITGB1	10	33197461	Frame_Shift_Del	DEL	CT	TCGA-CR-7368-01A-11D-2129-08	5737898	33197461	102337286	134	25083											
ANK3	288	broad.mit.edu	37	chr10	62029966	62029966	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgattttcctgggctgccaTatacaatggcgtgaaaccat	10	12	10	9	1	0	2	0	2	0	0	1	2	1	2	3	2	3	1	3	2	4	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:62029966T>C	uc001jky.2	-	5	628	c.436A>G	c.(436-438)ATG>GTG	p.M146V	ANK3_uc010qih.1_Missense_Mutation_p.M129V|ANK3_uc001jkz.3_Missense_Mutation_p.M140V|ANK3_uc001jlb.1_Translation_Start_Site	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	146	ANK 3.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TGGGCTGCCATATACAATGGC	0.398													19	33					0	0	0	0	C	62029966	C	C	62029966	3	2	139	1	0	0	0	0	1	0	0	0	622	1406	49	5	13186	5	ANK3	10	62029966	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08	28832505	62029966	73504781	135	25084											
ARID5B	84159	broad.mit.edu	37	chr10	63816914	63816914	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagccttgaccaagccgaaGaataaccataactgtaaaaa	18	7	6	10	1	1	2	1	1	0	1	1	3	1	2	4	0	4	1	4	0	8	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:63816914G>C	uc001jlt.1	+	6	911	c.885G>C	c.(883-885)AAG>AAC	p.K295N	ARID5B_uc001jlu.1_Missense_Mutation_p.K52N	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	295					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CCAAGCCGAAGAATAACCATA	0.458													18	22					0	0	0	0	C	63816914	C	C	63816914	3	2	139	1	0	0	0	0	1	0	0	0	922	933	33	2	907	2	ARID5B	10	63816914	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1786948	63816914	71717833	136	25085											
HERC4	26091	broad.mit.edu	37	chr10	69699408	69699408	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taatccagtaactgttgcatGcttctgcaaaataatatata	15	14	5	7	0	1	0	0	0	1	0	2	0	2	0	1	0	4	5	1	0	8	8			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:69699408G>A	uc001jng.3	-	22	2843	c.2532C>T	c.(2530-2532)AGC>AGT	p.S844S	HERC4_uc009xpq.2_Silent_p.S376S|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Silent_p.S836S|HERC4_uc009xpr.2_Intron|HERC4_uc001jni.3_Silent_p.S580S	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	844	HECT.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						ACTGTTGCATGCTTCTGCAAA	0.284													10	34					0	0	0	0	A	69699408	A	A	69699408	2	1	139	1	0	0	0	0	0	0	0	1	7099	1310	46	4		4	HERC4	10	69699408	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	5882494	69699408	65835339	137	25086											
HKDC1	80201	broad.mit.edu	37	chr10	71000451	71000451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctggtcaatgacaccgtggGgaccatgatgacctgtgcct	8	9	12	12	1	1	3	1	3	0	0	1	4	1	4	5	3	1	0	5	3	1	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:71000451G>A	uc001jpf.3	+	6	768	c.635G>A	c.(634-636)GGG>GAG	p.G212E	HKDC1_uc010qje.1_Missense_Mutation_p.G75E	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	212					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						GACACCGTGGGGACCATGATG	0.562													29	41					0	0	0	0	A	71000451	A	A	71000451	3	1	139	1	0	0	0	0	1	0	0	0	7232	1232	43	4	657	4	HKDC1	10	71000451	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1301043	71000451	64534296	138	25087											
IFIT1B	439996	broad.mit.edu	37	chr10	91143656	91143656	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataaatttaacacagcatcaGggaggaataaggcattttct	16	11	8	6	0	2	0	1	0	1	0	2	2	2	2	0	3	2	2	0	3	5	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:91143656G>A	uc001kgh.2	+	2	666	c.586G>A	c.(586-588)GGG>AGG	p.G196R	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron	NM_001010987	NP_001010987	Q5T764	IFT1B_HUMAN	interferon-induced protein with	196	TPR 4.						binding				0						CACAGCATCAGGGAGGAATAA	0.453													43	211					0	0	0	0	A	91143656	A	A	91143656	3	1	139	1	0	0	0	0	1	0	0	0	7561	1000	35	4	592	4	IFIT1B	10	91143656	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	20143205	91143656	44391091	139	25088											
SMC3	9126	broad.mit.edu	37	chr10	112356208	112356208	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggggttattatgacacaagGaagtctcgacttgaattgca	12	11	12	6	1	1	2	0	2	1	0	2	4	1	3	0	3	1	2	0	3	5	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:112356208G>A	uc001kze.2	+	19	2142	c.2016G>A	c.(2014-2016)AGG>AGA	p.R672R		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	672	Potential.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		ATGACACAAGGAAGTCTCGAC	0.373													28	53					0	0	0	0	A	112356208	A	A	112356208	2	1	139	1	0	0	0	0	0	0	0	1	14848	1165	41	2		2	SMC3	10	112356208	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	21212552	112356208	23178539	140	25089											
EBF3	253738	broad.mit.edu	37	chr10	131641455	131641455	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaggtccgccgcccgcttCagtaacacctcctaaaggaa	11	6	8	16	3	1	0	1	0	0	0	3	1	3	1	6	2	1	2	6	2	4	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:131641455C>T	uc001lki.1	-	12	1172	c.1113G>A	c.(1111-1113)CTG>CTA	p.L371L		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	380					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCGCCCGCTTCAGTAACACCT	0.602													4	10					0	0	0	0	T	131641455	T	T	131641455	2	4	139	1	0	0	0	0	0	0	0	1	4904	813	29	2		2	EBF3	10	131641455	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	19285247	131641455	3893292	141	25090											
ECHS1	1892	broad.mit.edu	37	chr10	135176399	135176399	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttgaagttggcctttctCttttccacaaacgcggtcat	7	16	7	11	2	3	1	1	1	2	0	5	1	4	1	2	2	1	1	2	2	2	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr10:135176399C>G	uc001lmu.2	-	8	917	c.846G>C	c.(844-846)AAG>AAC	p.K282N		NM_004092	NP_004083	P30084	ECHM_HUMAN	mitochondrial short-chain enoyl-coenzyme A	282					fatty acid beta-oxidation	mitochondrial matrix	enoyl-CoA hydratase activity|protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;1.62e-06)|OV - Ovarian serous cystadenocarcinoma(35;5.75e-06)|Epithelial(32;7.58e-06)		TGGCCTTTCTCTTTTCCACAA	0.517													4	75					0	0	0	0	G	135176399	G	G	135176399	3	3	139	1	0	0	0	0	1	0	0	0	4918	912	32	2	30	2	ECHS1	10	135176399	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	3534944	135176399	358348	142	25091											
TEAD1	7003	broad.mit.edu	37	chr11	12785959	12785959	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggaggaggaaaatcatcttAtcagacgaaggcaaaatgta	17	7	12	5	1	3	1	2	0	1	1	3	5	3	4	0	4	0	2	0	4	7	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:12785959A>T	uc001mkj.3	+	3	800	c.135A>T	c.(133-135)TTA>TTT	p.L45F		NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1	60	TEA.				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		AAATCATCTTATCAGACGAAG	0.488													23	42					0	0	0	0	T	12785959	T	T	12785959	3	4	139	1	0	0	0	0	1	0	0	0	15804	446	16	5	182	5	TEAD1	11	12785959	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08		12785959	122220557	143	25092											
CYP2R1	120227	broad.mit.edu	37	chr11	14907463	14907463	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaagatctaaactgaagaTctttgagaagagaagaaaaa	20	8	8	5	0	2	6	0	2	2	5	3	8	3	6	1	0	1	0	1	0	8	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:14907463T>A	uc001mlr.2	-	2	226	c.226A>T	c.(226-228)ATC>TTC	p.I76F	CYP2R1_uc001mlo.2_5'UTR|CYP2R1_uc001mlp.2_5'UTR|CYP2R1_uc001mlq.2_RNA|CYP2R1_uc001mls.1_Missense_Mutation_p.I21F	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	76					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	AAACTGAAGATCTTTGAGAAG	0.373													14	33					0	0	0	0	A	14907463	A	A	14907463	3	1	139	1	0	0	0	0	1	0	0	0	4190	1449	50	5	1295	5	CYP2R1	11	14907463	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08	2121504	14907463	120099053	144	25093											
ANO5	203859	broad.mit.edu	37	chr11	22248857	22248857	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttaatgcaggactcggaaGatggaagaacttattttgtc	12	14	10	5	1	0	2	0	0	0	2	2	5	0	5	0	3	2	1	0	3	5	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:22248857G>C	uc001mqi.2	+	7	690	c.373G>C	c.(373-375)GAT>CAT	p.D125H	ANO5_uc001mqj.2_Missense_Mutation_p.D124H	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	125	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						GGACTCGGAAGATGGAAGAAC	0.348													38	97					0	0	0	0	C	22248857	C	C	22248857	3	2	139	1	0	0	0	0	1	0	0	0	700	942	33	2	399	2	ANO5	11	22248857	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	7341394	22248857	112757659	145	25094											
OR4B1	119765	broad.mit.edu	37	chr11	48238839	48238839	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actccataattcagattctcGttatcatccaattgcccttc	10	15	3	13	1	3	1	2	0	1	1	7	1	5	1	3	0	1	1	3	0	3	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:48238839G>A	uc010rhs.1	+	1	478	c.478G>A	c.(478-480)GTT>ATT	p.V160I		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	160	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						TCAGATTCTCGTTATCATCCA	0.468													38	77					0	0	0	0	A	48238839	A	A	48238839	3	1	139	1	0	0	0	0	1	0	0	0	11098	1145	40	1	480	1	OR4B1	11	48238839	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	25989982	48238839	86767677	146	25095											
SPRYD5	84767	broad.mit.edu	37	chr11	55653074	55653074	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcagtgctctgaatgcaagaAgacaacgcggcagagaaacc	15	5	11	10	2	2	4	1	1	1	3	2	5	2	4	1	1	4	3	1	1	5	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:55653074A>C	uc010rip.1	+	2	262	c.170A>C	c.(169-171)AAG>ACG	p.K57T	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	57						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GAATGCAAGAAGACAACGCGG	0.512													4	14					0	0	0	0	C	55653074	C	C	55653074	3	2	139	1	0	0	0	0	1	0	0	0	15177	72	3	5	172	5	SPRYD5	11	55653074	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	7414235	55653074	79353442	147	25096											
OR10AG1	282770	broad.mit.edu	37	chr11	55735780	55735780	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaagggaaaaattgctaaGaaaaaaatacatgggagtct	21	7	9	4	0	1	1	0	0	1	1	1	3	1	3	0	2	2	1	0	2	9	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:55735780G>C	uc010rit.1	-	1	160	c.160C>G	c.(160-162)CTT>GTT	p.L54V		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	54	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					AAATTGCTAAGAAAAAAATAC	0.328													15	81					0	0	0	0	C	55735780	C	C	55735780	3	2	139	1	0	0	0	0	1	0	0	0	10951	942	33	2	748	2	OR10AG1	11	55735780	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	82706	55735780	79270736	148	25097											
INTS5	80789	broad.mit.edu	37	chr11	62416825	62416825	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccttaaggccacaggagaGaacccgggaaatgatggtgc	12	6	14	9	1	0	2	0	1	0	1	1	5	1	4	3	4	2	0	3	4	3	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:62416825G>A	uc001nud.2	-	2	780	c.727C>T	c.(727-729)CTC>TTC	p.L243F	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	243					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CCACAGGAGAGAACCCGGGAA	0.542													21	50					0	0	0	0	A	62416825	A	A	62416825	3	1	139	1	0	0	0	0	1	0	0	0	7820	942	33	2	2336	2	INTS5	11	62416825	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	6681045	62416825	72589691	149	25098											
NPAS4	266743	broad.mit.edu	37	chr11	66191403	66191403	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatgctgccctcattccctGaaaacattctttcccaggaa	10	11	5	15	0	2	1	1	1	1	0	4	2	4	2	4	1	3	1	4	1	3	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:66191403G>A	uc001ohx.1	+	7	1218	c.1042G>A	c.(1042-1044)GAA>AAA	p.E348K	NPAS4_uc010rpc.1_Missense_Mutation_p.E138K	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	348					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CTCATTCCCTGAAAACATTCT	0.577													29	181					0	0	0	0	A	66191403	A	A	66191403	3	1	139	1	0	0	0	0	1	0	0	0	10619	1291	45	2	1068	2	NPAS4	11	66191403	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	3774578	66191403	68815113	150	25099											
ACER3	55331	broad.mit.edu	37	chr11	76709867	76709867	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctatttatattgttacatggTaagtagtttggatcatctgc	10	18	8	5	0	2	0	1	0	1	0	2	1	2	1	0	2	2	4	0	2	6	9			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:76709867T>C	uc009yum.1	+	7	601	c.497_splice	c.e7+2	p.W166_splice	ACER3_uc010rsg.1_Splice_Site_p.W124_splice|ACER3_uc009yul.1_Splice_Site|ACER3_uc001oxu.2_Splice_Site|ACER3_uc009yun.1_Splice_Site_p.W124_splice|ACER3_uc009yuo.1_Splice_Site_p.W71_splice|ACER3_uc010rsh.1_Splice_Site_p.W129_splice|ACER3_uc010rsi.1_Splice_Site_p.W71_splice|ACER3_uc010rsj.1_Splice_Site_p.W71_splice	NM_018367	NP_060837	Q9NUN7	ACER3_HUMAN	phytoceramidase, alkaline						ceramide metabolic process|phytosphingosine biosynthetic process|positive regulation of cell proliferation|sphingosine biosynthetic process	integral to endoplasmic reticulum membrane|integral to Golgi membrane	phytoceramidase activity				0						TGTTACATGGTAAGTAGTTTG	0.318													7	29					0	0	0	0	C	76709867	C	C	76709867	5	2	139	1	0	0	0	0	0	0	1	0	140	1652	57	5	525	5	ACER3	11	76709867	Splice_Site	SNP	T	TCGA-CR-7368-01A-11D-2129-08	10518464	76709867	58296649	151	25100											
FAT3	120114	broad.mit.edu	37	chr11	92624013	92624013	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcctcacccattccccaacGaaacggatttggtgggcccg	8	8	9	16	3	1	0	1	0	0	0	3	2	3	1	5	3	2	0	5	3	2	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:92624013G>A	uc001pdj.3	+	25	13425	c.13408G>A	c.(13408-13410)GAA>AAA	p.E4470K	FAT3_uc001pdi.3_Missense_Mutation_p.E942K	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4502	Pro-rich.|Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTCCCCAACGAAACGGATTT	0.592										TCGA Ovarian(4;0.039)			17	29					0	0	0	0	A	92624013	A	A	92624013	3	1	139	1	0	0	0	0	1	0	0	0	5723	1059	37	1	13506	1	FAT3	11	92624013	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	15914146	92624013	42382503	152	25101											
SLC35F2	54733	broad.mit.edu	37	chr11	107676147	107676147	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctaaaaactcctgtctgctCagcttcttcacgatgtattc	9	14	5	13	1	4	0	2	0	2	0	6	1	5	0	2	0	3	3	2	0	4	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:107676147C>T	uc001pjq.2	-	5	1090	c.669G>A	c.(667-669)CTG>CTA	p.L223L	SLC35F2_uc010rvu.1_Silent_p.L75L|SLC35F2_uc001pjs.2_3'UTR	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	223					transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		CCTGTCTGCTCAGCTTCTTCA	0.408													5	46					0	0	0	0	T	107676147	T	T	107676147	2	4	139	1	0	0	0	0	0	0	0	1	14653	813	29	2		2	SLC35F2	11	107676147	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	15052134	107676147	27330369	153	25102											
SIK3	23387	broad.mit.edu	37	chr11	116729228	116729228	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtatagtgtggcggctgctGatgtgcactgggagggaagg	7	9	20	5	1	0	1	0	1	0	0	0	3	0	3	0	6	2	4	0	6	3	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:116729228G>C	uc001ppy.2	-	20	2671	c.2635C>G	c.(2635-2637)CAG>GAG	p.Q879E	SIK3_uc001ppz.2_Missense_Mutation_p.Q718E|SIK3_uc001pqa.2_Missense_Mutation_p.Q819E|SIK3_uc001ppw.2_Missense_Mutation_p.Q236E|SIK3_uc001ppx.2_Missense_Mutation_p.Q257E|SIK3_uc001pqb.2_Missense_Mutation_p.Q182E	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	879	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.R879R(1)		ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						GGCGGCTGCTGATGTGCACTG	0.587													12	107					0	0	0	0	C	116729228	C	C	116729228	3	2	139	1	0	0	0	0	1	0	0	0	14384	1299	45	2	1172	2	SIK3	11	116729228	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	9053081	116729228	18277288	154	25103											
OR6T1	219874	broad.mit.edu	37	chr11	123814028	123814028	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacgaaagaagtggtcaataCcattggggccacagaaaggc	15	5	12	9	1	1	2	1	0	0	2	1	3	1	2	2	4	1	0	2	4	5	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:123814028C>A	uc010sab.1	-	1	518	c.518G>T	c.(517-519)GGT>GTT	p.G173V		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTGGTCAATACCATTGGGGCC	0.562													25	21					7.76418e-22	8.57988e-22	1	0	A	123814028	A	A	123814028	3	1	139	1	0	0	0	0	1	0	0	0	11264	507	18	4	456	4	OR6T1	11	123814028	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	7084800	123814028	11192488	155	25104											
PRDM10	56980	broad.mit.edu	37	chr11	129780421	129780421	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggtacgtgtgctgcacaGaggaattctgctgctgctgc	7	10	14	10	1	1	1	0	0	1	1	1	2	1	2	0	2	7	7	0	2	2	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr11:129780421G>A	uc001qfm.2	-	20	3357	c.3125C>T	c.(3124-3126)TCT>TTT	p.S1042F	PRDM10_uc001qfj.2_Missense_Mutation_p.S943F|PRDM10_uc001qfk.2_Missense_Mutation_p.S905F|PRDM10_uc001qfl.2_Missense_Mutation_p.S956F|PRDM10_uc010sbx.1_Missense_Mutation_p.S952F|PRDM10_uc001qfn.2_Missense_Mutation_p.S1038F	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	1029	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		GTGCTGCACAGAGGAATTctg	0.522													11	45					0	0	0	0	A	129780421	A	A	129780421	3	1	139	1	0	0	0	0	1	0	0	0	12513	942	33	2	369	2	PRDM10	11	129780421	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	5966393	129780421	5226095	156	25105											
IFLTD1	160492	broad.mit.edu	37	chr12	25702360	25702360	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaatctgaggactagacagAtagtaaccaagaggcattcc	15	8	9	9	0	1	4	0	1	1	3	2	5	2	5	2	2	1	2	2	2	5	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:25702360A>T	uc001rgs.2	-	2	297	c.147T>A	c.(145-147)TAT>TAA	p.Y49*	IFLTD1_uc001rgt.1_5'UTR|IFLTD1_uc010sji.1_Nonsense_Mutation_p.Y70*|IFLTD1_uc010sjj.1_Intron|IFLTD1_uc009zjc.2_Nonsense_Mutation_p.Y70*	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	49						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					GACTAGACAGATAGTAACCAA	0.398													22	37					0	0	0	0	T	25702360	T	T	25702360	4	4	139	1	0	0	0	0	0	1	0	0	7569	340	12	5	1047	5	IFLTD1	12	25702360	Nonsense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08		25702360	108149535	157	25106											
RASSF8	11228	broad.mit.edu	37	chr12	26217552	26217552	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgctagtgatgtgcagctCattctacgacgaactgggcc	9	11	11	10	2	2	1	1	1	1	0	2	3	2	1	1	1	5	3	1	1	4	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:26217552C>G	uc001rgx.2	+	3	446	c.225C>G	c.(223-225)CTC>CTG	p.L75L	RASSF8_uc001rgy.2_Silent_p.L75L|RASSF8_uc001rgz.2_Silent_p.L75L|RASSF8_uc009zjd.1_Silent_p.L75L|RASSF8_uc009zje.1_Silent_p.L75L	NM_007211	NP_009142	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family	75	Ras-associating.				signal transduction						0	Colorectal(261;0.0847)					ATGTGCAGCTCATTCTACGAC	0.463													21	109					0	0	0	0	G	26217552	G	G	26217552	2	3	139	1	0	0	0	0	0	0	0	1	13157	813	29	2		2	RASSF8	12	26217552	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	515192	26217552	107634343	158	25107											
C12orf35	55196	broad.mit.edu	37	chr12	32135856	32135856	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcagtggacaagaatcctCaacaaaaggaatgcctgcta	15	8	9	9	0	1	1	1	0	0	1	2	3	2	3	2	2	4	2	2	2	7	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:32135856C>T	uc001rks.2	+	4	2381	c.1967C>T	c.(1966-1968)TCA>TTA	p.S656L		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	656										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CAAGAATCCTCAACAAAAGGA	0.423													6	59					0	0	0	0	T	32135856	T	T	32135856	3	4	139	1	0	0	0	0	1	0	0	0	1688	838	29	2	1969	2	C12orf35	12	32135856	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	5918304	32135856	101716039	159	25108											
NELL2	4753	broad.mit.edu	37	chr12	45173642	45173642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacttacttattgcagtCaatgtgtaaaatcaaatggg	14	13	7	7	0	2	0	2	0	0	0	2	0	2	0	0	1	3	2	0	1	7	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:45173642C>T	uc001rog.2	-	4	1094	c.499G>A	c.(499-501)GAC>AAC	p.D167N	NELL2_uc001rof.3_Missense_Mutation_p.D166N|NELL2_uc001roh.2_Missense_Mutation_p.D167N|NELL2_uc009zkd.2_Missense_Mutation_p.D166N|NELL2_uc010skz.1_Missense_Mutation_p.D217N|NELL2_uc010sla.1_Missense_Mutation_p.D190N|NELL2_uc001roi.1_Missense_Mutation_p.D167N|NELL2_uc010slb.1_Missense_Mutation_p.D166N|NELL2_uc001roj.2_Missense_Mutation_p.D167N	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	167	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TTATTGCAGTCAATGTGTAAA	0.403													8	82					0	0	0	0	T	45173642	T	T	45173642	3	4	139	1	0	0	0	0	1	0	0	0	10388	826	29	2	2019	2	NELL2	12	45173642	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	13037786	45173642	88678253	160	25109											
DDX23	9416	broad.mit.edu	37	chr12	49225034	49225034	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatccttggccccagccttGaggttggacaacgcaaactc	10	9	9	13	1	0	1	0	1	0	0	2	2	1	2	4	3	3	2	4	3	3	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:49225034G>C	uc001rsm.2	-	16	2221	c.2130C>G	c.(2128-2130)CTC>CTG	p.L710L		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	710	Helicase C-terminal.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						CCCCAGCCTTGAGGTTGGACA	0.483													19	146					0	0	0	0	C	49225034	C	C	49225034	2	2	139	1	0	0	0	0	0	0	0	1	4367	1277	45	2		2	DDX23	12	49225034	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	4051392	49225034	84626861	161	25110											
SCN8A	6334	broad.mit.edu	37	chr12	52099309	52099309	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtggtggccatggcttatGaagaacagaatcaggcaaca	13	8	12	8	0	1	3	1	1	0	2	1	3	1	3	1	4	2	2	1	4	5	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:52099309G>A	uc001ryw.2	+	10	1421	c.1243G>A	c.(1243-1245)GAA>AAA	p.E415K	SCN8A_uc010snl.1_Missense_Mutation_p.E280K|SCN8A_uc001ryx.1_Missense_Mutation_p.E280K|SCN8A_uc001ryz.1_Missense_Mutation_p.E280K|SCN8A_uc001ryy.2_Missense_Mutation_p.E280K	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	415	I.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CATGGCTTATGAAGAACAGAA	0.453													4	33					0	0	0	0	A	52099309	A	A	52099309	3	1	139	1	0	0	0	0	1	0	0	0	13989	1291	45	2	1277	2	SCN8A	12	52099309	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	2874275	52099309	81752586	162	25111											
MYF5	4617	broad.mit.edu	37	chr12	81112735	81112735	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaacctgggttgcctctcCaggatctggcttctctctct	5	13	9	14	0	4	0	0	0	4	0	7	1	4	1	3	3	3	3	3	3	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:81112735C>A	uc001szg.2	+	3	808	c.673C>A	c.(673-675)CAG>AAG	p.Q225K		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	225					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						GTTGCCTCTCCAGGATCTGGC	0.488													25	60					7.41945e-09	7.89185e-09	1	0	A	81112735	A	A	81112735	3	1	139	1	0	0	0	0	1	0	0	0	10080	595	21	4	683	4	MYF5	12	81112735	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	29013426	81112735	52739160	163	25112											
CUX2	23316	broad.mit.edu	37	chr12	111785464	111785464	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagccctgactctgagactGaggaccagaagccaaccgtg	12	5	12	12	1	1	5	0	3	1	3	1	7	1	6	4	1	3	0	4	1	2	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:111785464G>A	uc001tsa.1	+	22	3949	c.3796G>A	c.(3796-3798)GAG>AAG	p.E1266K		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1266						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CTCTGAGACTGAGGACCAGAA	0.622													11	32					0	0	0	0	A	111785464	A	A	111785464	3	1	139	1	0	0	0	0	1	0	0	0	4082	1291	45	2	3882	2	CUX2	12	111785464	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	30672729	111785464	22066431	164	25113											
TRIAP1	51499	broad.mit.edu	37	chr12	120882720	120882720	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccatggcccatgaactcCagtccttcaataggaatctc	10	11	7	13	0	2	1	1	1	1	0	5	2	4	2	4	2	2	0	4	2	4	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:120882720C>T	uc001tyg.2	-	2	226	c.186G>A	c.(184-186)CTG>CTA	p.L62L	GATC_uc010szi.1_5'Flank	NM_016399	NP_057483	O43715	TRIA1_HUMAN	p53-inducible cell-survival factor	62					anti-apoptosis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	mitochondrion|perinuclear region of cytoplasm	caspase inhibitor activity|protein binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCATGAACTCCAGTCCTTCAA	0.403													32	156					0	0	0	0	T	120882720	T	T	120882720	2	4	139	1	0	0	0	0	0	0	0	1	16548	581	21	4		4	TRIAP1	12	120882720	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	9097256	120882720	12969175	165	25114											
CLIP1	6249	broad.mit.edu	37	chr12	122794385	122794385	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttctcttcttgcaacgctGaaagctgctgggacttctga	7	13	10	11	2	3	2	0	2	3	0	4	3	3	3	0	1	4	5	0	1	2	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr12:122794385G>T	uc001ucg.1	-	19	3624	c.3518C>A	c.(3517-3519)TCA>TAA	p.S1173*	CLIP1_uc001uch.1_Nonsense_Mutation_p.S1162*|CLIP1_uc001uci.1_Nonsense_Mutation_p.S1127*|CLIP1_uc001ucj.1_Nonsense_Mutation_p.S748*	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1173	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TTGCAACGCTGAAAGCTGCTG	0.507													19	39					6.94344e-10	7.44127e-10	1	0	T	122794385	T	T	122794385	4	4	139	1	0	0	0	0	0	1	0	0	3547	1294	45	2	826	2	CLIP1	12	122794385	Nonsense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1911665	122794385	11057510	166	25115											
DIAPH3	81624	broad.mit.edu	37	chr13	60557957	60557957	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcgatatgtgaagtctggatCcattccatctctatgcaata	11	14	7	9	1	2	1	0	1	2	0	6	3	4	2	2	1	1	1	2	1	5	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr13:60557957C>A	uc001vht.2	-	13	1645	c.1426G>T	c.(1426-1428)GAT>TAT	p.D476Y	DIAPH3_uc001vhu.2_Missense_Mutation_p.D213Y|DIAPH3_uc001vhv.2_Missense_Mutation_p.D54Y	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	476	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AAGTCTGGATCCATTCCATCT	0.294													31	68					3.03874e-20	3.34497e-20	1	0	A	60557957	A	A	60557957	3	1	139	1	0	0	0	0	1	0	0	0	4542	855	30	2	2239	2	DIAPH3	13	60557957	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08		60557957	54611921	167	25116											
NGDN	25983	broad.mit.edu	37	chr14	23945265	23945265	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaggatgaggaggaagatGaagcagaagatgaccagtct	15	6	15	5	0	1	7	0	4	1	3	1	10	1	10	1	3	1	1	1	3	3	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr14:23945265G>A	uc001wjy.2	+	7	475	c.448G>A	c.(448-450)GAA>AAA	p.E150K	NGDN_uc001wjz.2_Missense_Mutation_p.E150K|NGDN_uc001wka.2_5'Flank	NM_001042635	NP_001036100	Q8NEJ9	NGDN_HUMAN	neuroguidin isoform 1	150	Necessary for interaction with EIF4E (By similarity).				regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus					0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GGAGGAAGATGAAGCAGAAGA	0.423													5	61					0	0	0	0	A	23945265	A	A	23945265	3	1	139	1	0	0	0	0	1	0	0	0	10447	1291	45	2	474	2	NGDN	14	23945265	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08		23945265	83404275	168	25117											
RIN3	79890	broad.mit.edu	37	chr14	93118912	93118912	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggccaaagccctgcttcTcaggctgggactcagcaccc	8	6	12	15	0	2	0	2	0	1	0	3	2	2	1	3	3	3	3	3	3	1	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr14:93118912T>A	uc001yap.2	+	6	1670	c.1518T>A	c.(1516-1518)TCT>TCA	p.S506S	RIN3_uc010auk.2_Silent_p.S168S|RIN3_uc001yaq.2_Silent_p.S431S|RIN3_uc001yar.1_Silent_p.S168S|RIN3_uc001yas.1_Silent_p.S168S	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	506	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				GCCCTGCTTCTCAGGCTGGGA	0.652													20	40					0	0	0	0	A	93118912	A	A	93118912	2	1	139	1	0	0	0	0	0	0	0	1	13438	1538	54	5		5	RIN3	14	93118912	Silent	SNP	T	TCGA-CR-7368-01A-11D-2129-08	69173647	93118912	14230628	169	25118											
ATG2B	55102	broad.mit.edu	37	chr14	96807957	96807957	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggtcagaaggtgctatctCtggtaaatttctagttagct	9	15	11	6	0	3	1	1	0	2	1	4	1	3	1	0	3	2	4	0	3	6	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr14:96807957C>T	uc001yfi.2	-	6	1191	c.826G>A	c.(826-828)GAG>AAG	p.E276K		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	276										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GGTGCTATCTCTGGTAAATTT	0.438													16	82					0	0	0	0	T	96807957	T	T	96807957	3	4	139	1	0	0	0	0	1	0	0	0	1096	922	32	2	5558	2	ATG2B	14	96807957	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	3689045	96807957	10541583	170	25119											
AHNAK2	113146	broad.mit.edu	37	chr14	105413766	105413767	+	Frame_Shift_Del	DEL	AG	-	-																															tcggcttccaccttcagctcAgacacatccaccaacgcctc																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr14:105413766_105413767delAG	uc010axc.1	-	7	8141_8142	c.8021_8022delCT	c.(8020-8022)TCTfs	p.S2674fs	AHNAK2_uc001ypx.2_Frame_Shift_Del_p.S2574fs	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2674						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTTCAGCTCAGACACATCCAC	0.564													---	---	---								-	105413767	-	-	105413766	7	5	139	1	0	1	0	1	0	0	0	0	415	175	7	0	9369	0	AHNAK2	14	105413766	Frame_Shift_Del	DEL	AG	TCGA-CR-7368-01A-11D-2129-08	8605809	105413766	1935774	171	25120											
AHNAK2	113146	broad.mit.edu	37	chr14	105418065	105418066	+	Missense_Mutation	DNP	GC	AA	AA																															ttgggcaggtgccctttgaaGccggctccctcaggcacgtg																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr14:105418065_105418066GC>AA	uc010axc.1	-	7	3842_3843	c.3722_3723GC>TT	c.(3721-3723)GGC>GTT	p.G1241V	AHNAK2_uc001ypx.2_Missense_Mutation_p.G1141V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1241						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCCCTTTGAAGCCGGCTCCCTC	0.639													78	36					0	0	0	0	AA	105418066	AA	AA	105418065	3	1	139	1	0	0	0	0	1	0	0	0	415	958	34	4	13668	4	AHNAK2	14	105418065	Missense_Mutation	DNP	GC	TCGA-CR-7368-01A-11D-2129-08	4299	105418065	1931475	172	25121											
MKRN3	7681	broad.mit.edu	37	chr15	23812217	23812217	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgagggctggggagatgagCctcctgggccaggtggtggg	5	7	21	8	0	0	3	0	2	0	1	1	4	1	3	3	7	1	1	3	7	0	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:23812217C>A	uc001ywh.3	+	1	1764	c.1288C>A	c.(1288-1290)CCT>ACT	p.P430T	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Intron	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	430						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GGGAGATGAGCCTCCTGGGCC	0.522													15	46					5.01169e-05	5.2328e-05	1	0	A	23812217	A	A	23812217	3	1	139	1	0	0	0	0	1	0	0	0	9661	739	26	4	1290	4	MKRN3	15	23812217	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08		23812217	78719175	173	25122											
LCMT2	9836	broad.mit.edu	37	chr15	43622164	43622164	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaggctgcgtcgagccccGcggcgcccagggcctcctcc	3	5	15	18	5	0	1	0	1	0	0	3	2	2	1	6	3	2	1	6	3	0	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:43622164G>A	uc001zrg.2	-	1	728	c.524C>T	c.(523-525)GCG>GTG	p.A175V	LCMT2_uc010udn.1_Intron|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	175					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	GTCGAGCCCCGCGGCGCCCAG	0.716													23	28					0	0	0	0	A	43622164	A	A	43622164	3	1	139	1	0	0	0	0	1	0	0	0	8719	1087	38	1	1540	1	LCMT2	15	43622164	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	19809947	43622164	58909228	174	25123											
GNB5	10681	broad.mit.edu	37	chr15	52446255	52446255	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgccccagggcctccaccCgctccgccacctggtgcact	5	6	9	21	2	0	0	0	0	0	0	2	0	2	0	8	2	2	2	8	2	0	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:52446255C>T	uc002abt.1	-	4	322	c.257G>A	c.(256-258)CGG>CAG	p.R86Q	GNB5_uc002abr.1_Missense_Mutation_p.R44Q|GNB5_uc002abs.1_Missense_Mutation_p.R44Q|GNB5_uc002abu.3_Missense_Mutation_p.R44Q	NM_016194	NP_057278	O14775	GBB5_HUMAN	guanine nucleotide-binding protein, beta-5	86						heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)	1				all cancers(107;0.0163)		GGCCTCCACCCGCTCCGCCAC	0.562													9	29					0	0	0	0	T	52446255	T	T	52446255	3	4	139	1	0	0	0	0	1	0	0	0	6558	652	23	1	970	1	GNB5	15	52446255	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	8824091	52446255	50085137	175	25124											
MYO5A	4644	broad.mit.edu	37	chr15	52609388	52609388	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attcatcagattcttgtcacGcagccattcttccagttgac	9	14	6	12	1	5	2	3	1	2	1	6	2	6	2	2	0	1	2	2	0	0	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:52609388G>C	uc002aby.2	-	39	5435	c.5191C>G	c.(5191-5193)CGT>GGT	p.R1731G	MYO5A_uc002abx.3_Missense_Mutation_p.R1704G|MYO5A_uc010ugd.1_Missense_Mutation_p.R453G	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1731	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TTCTTGTCACGCAGCCATTCT	0.368													7	50					0	0	0	0	C	52609388	C	C	52609388	3	2	139	1	0	0	0	0	1	0	0	0	10131	1087	38	3	388	3	MYO5A	15	52609388	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	163133	52609388	49922004	176	25125											
LMAN1L	79748	broad.mit.edu	37	chr15	75105240	75105240	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cccttattctgccttctcctCctgctcctggacccccacag	4	12	5	20	0	2	0	0	0	2	0	5	1	4	1	7	1	2	1	7	1	1	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:75105240C>G	uc002ayt.1	+	1	47	c.45C>G	c.(43-45)CTC>CTG	p.L15L	LMAN1L_uc010bkd.2_Intron|LMAN1L_uc010ulo.1_Intron|LMAN1L_uc010bke.1_Silent_p.L15L	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	15						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						GCCTTCTCCTCCTGCTCCTGG	0.632													33	60					0	0	0	0	G	75105240	G	G	75105240	2	3	139	1	0	0	0	0	0	0	0	1	8879	842	30	2		2	LMAN1L	15	75105240	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	22495852	75105240	27426152	177	25126											
LMAN1L	79748	broad.mit.edu	37	chr15	75105354	75105354	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctggggctggaatacccttCtggagccatcatggaggtga	8	9	14	10	0	2	1	1	1	1	0	2	4	2	4	3	6	2	1	3	6	2	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:75105354C>T	uc002ayt.1	+	1	161	c.159C>T	c.(157-159)TTC>TTT	p.F53F	LMAN1L_uc010bkd.2_5'UTR|LMAN1L_uc010ulo.1_5'UTR|LMAN1L_uc010bke.1_Silent_p.F53F	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	53	Lumenal (Potential).|L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						GAATACCCTTCTGGAGCCATC	0.617													23	31					0	0	0	0	T	75105354	T	T	75105354	2	4	139	1	0	0	0	0	0	0	0	1	8879	912	32	2		2	LMAN1L	15	75105354	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	114	75105354	27426038	178	25127											
FURIN	5045	broad.mit.edu	37	chr15	91422758	91422758	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagcagccggcatcattgctCtcaccctggaggccaagtaa	10	8	10	13	1	2	0	2	0	1	0	3	1	2	1	3	3	3	4	3	3	3	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:91422758C>G	uc002bpu.1	+	10	1354	c.1138C>G	c.(1138-1140)CTC>GTC	p.L380V		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	380					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CATCATTGCTCTCACCCTGGA	0.627													4	31					0	0	0	0	G	91422758	G	G	91422758	3	3	139	1	0	0	0	0	1	0	0	0	6133	913	32	2	1172	2	FURIN	15	91422758	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	16317404	91422758	11108634	179	25128											
ST8SIA2	8128	broad.mit.edu	37	chr15	92981732	92981732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgagctcctccccaggacttCgccactgaagaataagcact	11	7	8	15	2	0	2	0	1	0	1	3	4	2	3	4	1	2	2	4	1	3	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr15:92981732C>T	uc002bra.2	+	4	595	c.440C>T	c.(439-441)TCG>TTG	p.S147L	ST8SIA2_uc002brb.2_Missense_Mutation_p.S126L	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	147	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			CCCAGGACTTCGCCACTGAAG	0.537													9	106					0	0	0	0	T	92981732	T	T	92981732	3	4	139	1	0	0	0	0	1	0	0	0	15298	893	31	1	454	1	ST8SIA2	15	92981732	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	1558974	92981732	9549660	180	25129											
KIAA0556	23247	broad.mit.edu	37	chr16	27720105	27720105	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgtccaactggggcaactCgtggtgggtgggtctcacag	6	9	15	11	1	1	0	1	0	1	0	4	0	2	0	2	5	2	1	2	5	2	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:27720105C>T	uc002dow.2	+	13	1493	c.1469C>T	c.(1468-1470)TCG>TTG	p.S490L	KIAA0556_uc002dox.1_Missense_Mutation_p.S398L	NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	490								p.S490S(1)		ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TGGGGCAACTCGTGGTGGGTG	0.483													7	59					0	0	0	0	T	27720105	T	T	27720105	3	4	139	1	0	0	0	0	1	0	0	0	8222	893	31	1	1519	1	KIAA0556	16	27720105	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08		27720105	62634648	181	25130											
SLC5A2	6524	broad.mit.edu	37	chr16	31498885	31498885	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggcgggtattcgggtctcttCgacaaatacctgggagcagc	8	9	14	10	3	1	0	0	0	1	0	4	2	1	1	1	4	3	2	1	4	3	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:31498885C>G	uc002ecf.3	+	7	709	c.690C>G	c.(688-690)TTC>TTG	p.F230L	SLC5A2_uc010car.2_RNA|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	230	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						CGGGTCTCTTCGACAAATACC	0.652													4	85					0	0	0	0	G	31498885	G	G	31498885	3	3	139	1	0	0	0	0	1	0	0	0	14729	883	31	3	716	3	SLC5A2	16	31498885	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	3778780	31498885	58855868	182	25131											
CAPNS2	84290	broad.mit.edu	37	chr16	55601232	55601232	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcttccagctaaatgaacaActttaccaaatgattgtccg	13	11	7	10	1	0	2	0	2	0	0	2	2	2	2	3	1	4	2	3	1	6	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:55601232A>G	uc002eid.1	+	1	649	c.564A>G	c.(562-564)CAA>CAG	p.Q188Q	LPCAT2_uc002eie.3_Intron|LPCAT2_uc002eic.2_Intron	NM_032330	NP_115706	Q96L46	CPNS2_HUMAN	calpain small subunit 2	188	EF-hand 3.					cytoplasm|plasma membrane	calcium ion binding				0						TAAATGAACAACTTTACCAAA	0.483													47	88					0	0	0	0	G	55601232	G	G	55601232	2	3	139	1	0	0	0	0	0	0	0	1	2646	40	2	5		5	CAPNS2	16	55601232	Silent	SNP	A	TCGA-CR-7368-01A-11D-2129-08	24102347	55601232	34753521	183	25132											
ATMIN	23300	broad.mit.edu	37	chr16	81077197	81077197	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttgctctcttaaggagaGcctacctcttttcaaaattg	9	14	8	10	0	3	1	1	0	2	1	4	2	3	1	2	2	3	2	2	2	4	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:81077197G>C	uc002ffz.1	+	4	1112	c.1094G>C	c.(1093-1095)AGC>ACC	p.S365T	ATMIN_uc002fga.2_Missense_Mutation_p.S207T|ATMIN_uc010vnn.1_Missense_Mutation_p.S136T|ATMIN_uc002fgb.1_Missense_Mutation_p.S207T	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	365	Required for formation of RAD51 foci.				response to DNA damage stimulus	nucleus	zinc ion binding				0						CTTAAGGAGAGCCTACCTCTT	0.458													9	52					0	0	0	0	C	81077197	C	C	81077197	3	2	139	1	0	0	0	0	1	0	0	0	1112	971	34	4	1108	4	ATMIN	16	81077197	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	25475965	81077197	9277556	184	25133											
SLC7A5	8140	broad.mit.edu	37	chr16	87885358	87885359	+	Frame_Shift_Ins	INS	-	A	A																															tctggacgaagcccagcaggINSatgatcagggccagggccag																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:87885358_87885359insA	uc002fkm.2	-	2	707_708	c.635_636insT	c.(634-636)ATCfs	p.I212fs		NM_003486	NP_003477	Q01650	LAT1_HUMAN	solute carrier family 7 (cationic amino acid	212	Helical; (Potential).				blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding				0				BRCA - Breast invasive adenocarcinoma(80;0.049)		AGCCCAGCAGGATGATCAGGGC	0.668													---	---	---								A	87885359	A	A	87885358	7	5	139	1	0	1	1	0	0	0	0	0	14764	1164	41	0	923	0	SLC7A5	16	87885358	Frame_Shift_Ins	INS	-	TCGA-CR-7368-01A-11D-2129-08	6808161	87885358	2469395	185	25134											
FANCA	2175	broad.mit.edu	37	chr16	89849296	89849296	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtccccagctgatgacaaatCctcgtagagtcccatgtttt	9	12	8	12	1	0	3	0	2	0	1	4	3	3	3	4	0	1	3	4	0	2	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr16:89849296C>T	uc002fou.1	-	17	1639	c.1597G>A	c.(1597-1599)GAT>AAT	p.D533N	FANCA_uc010vpn.1_Missense_Mutation_p.D533N	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	533					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GATGACAAATCCTCGTAGAGT	0.488			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				7	40					0	0	0	0	T	89849296	T	T	89849296	3	4	139	1	0	0	0	0	1	0	0	0	5694	855	30	2	2878	2	FANCA	16	89849296	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	1963938	89849296	505457	186	25135											
ACADVL	37	broad.mit.edu	37	chr17	7127131	7127131	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcatctgttctttgtccctaGgaggcagcctggaaggtgac	7	12	12	10	0	3	1	1	1	2	0	4	3	4	3	2	4	1	2	2	4	2	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:7127131G>A	uc002gev.2	+	13	1421	c.1270_splice	c.e13-1	p.E424_splice	ACADVL_uc010vtp.1_Splice_Site_p.E434_splice|ACADVL_uc002gew.2_Splice_Site_p.E402_splice|ACADVL_uc002gex.2_Splice_Site_p.E348_splice|uc002gey.1_5'Flank|MIR324_hsa-mir-324|MI0000813_5'Flank	NM_000018	NP_000009	P49748	ACADV_HUMAN	acyl-Coenzyme A dehydrogenase, very long chain						energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			ovary(3)	3						TTTGTCCCTAGGAGGCAGCCT	0.557													24	48					0	0	0	0	A	7127131	A	A	7127131	5	1	139	1	0	0	0	0	0	0	1	0	116	1014	35	4	1319	4	ACADVL	17	7127131	Splice_Site	SNP	G	TCGA-CR-7368-01A-11D-2129-08		7127131	74068079	187	25136											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	6	9	15	11	2	1	2	1	2	0	0	2	3	2	3	4	4	2	2	4	4	0	1	rs11540652		TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	43					0	0	0	0	T	7577538	T	T	7577538	3	4	139	1	0	0	0	0	1	0	0	0	16448	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	450407	7577538	73617672	188	25137											
MFSD6L	162387	broad.mit.edu	37	chr17	8701980	8701980	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttcaccaggtgggtttctGaagccaggcatttccacctc	7	12	9	13	0	2	1	1	1	1	0	4	1	3	1	4	3	1	2	4	3	1	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:8701980G>A	uc002glp.1	-	1	607	c.459C>T	c.(457-459)TTC>TTT	p.F153F		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	153						integral to membrane				central_nervous_system(1)	1						GTGGGTTTCTGAAGCCAGGCA	0.582													11	93					0	0	0	0	A	8701980	A	A	8701980	2	1	139	1	0	0	0	0	0	0	0	1	9589	1281	45	2		2	MFSD6L	17	8701980	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1124442	8701980	72493230	189	25138											
FAM18B	51030	broad.mit.edu	37	chr17	18694255	18694255	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tattctttcgagtcagtgcaAtcatcgtctatcttctctgt	7	18	6	10	2	6	0	2	0	4	0	9	1	6	0	0	0	1	1	0	0	3	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:18694255A>G	uc002gum.2	+	3	167	c.142A>G	c.(142-144)ATC>GTC	p.I48V	FAM18B_uc002gun.2_5'UTR	NM_016078	NP_057162	Q9NYZ1	F18B1_HUMAN	hypothetical protein LOC51030	48	Helical; (Potential).			I -> T (in Ref. 4; BAF83502).		integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (53;0.0872)|READ - Rectum adenocarcinoma(1115;0.0967)		AGTCAGTGCAATCATCGTCTA	0.393													110	136					0	0	0	0	G	18694255	G	G	18694255	3	3	139	1	0	0	0	0	1	0	0	0	5547	101	4	5	152	5	FAM18B	17	18694255	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	9992275	18694255	62500955	190	25139											
MYO18A	399687	broad.mit.edu	37	chr17	27442707	27442707	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatctcccaggccactctcCtcggggccctggcggaagga	6	6	12	17	2	2	0	0	0	2	0	5	2	2	2	5	6	0	0	5	6	1	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:27442707C>T	uc002hdt.1	-	12	2360	c.2202G>A	c.(2200-2202)GAG>GAA	p.E734E	MYO18A_uc010wbc.1_Silent_p.E276E|MYO18A_uc002hds.2_Silent_p.E276E|MYO18A_uc010csa.1_Silent_p.E734E|MYO18A_uc002hdu.1_Silent_p.E734E|MYO18A_uc010wbd.1_Silent_p.E403E	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	734	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GGCCACTCTCCTCGGGGCCCT	0.642													7	6					0	0	0	0	T	27442707	T	T	27442707	2	4	139	1	0	0	0	0	0	0	0	1	10118	680	24	4		4	MYO18A	17	27442707	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	8748452	27442707	53752503	191	25140											
WNK4	65266	broad.mit.edu	37	chr17	40947834	40947834	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaccagggaagctctggctGagagcgaccgtgcagctgag	10	5	16	10	2	1	3	0	2	1	2	1	6	1	4	2	2	4	4	2	2	1	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:40947834G>C	uc002ibj.2	+	16	3235	c.3214G>C	c.(3214-3216)GAG>CAG	p.E1072Q	WNK4_uc010wgx.1_Missense_Mutation_p.E736Q|CCDC56_uc010wgz.1_Missense_Mutation_p.Q142E	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1072					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		AGCTCTGGCTGAGAGCGACCG	0.607													3	40					0	0	0	0	C	40947834	C	C	40947834	3	2	139	1	0	0	0	0	1	0	0	0	17448	1291	45	2	3276	2	WNK4	17	40947834	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	13505127	40947834	40247376	192	25141											
IMP5	162540	broad.mit.edu	37	chr17	43923106	43923106	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttctatgaccactttgtCtatgtcaccattgggatctt	7	18	6	10	0	5	1	1	1	4	0	5	2	5	2	2	1	0	0	2	1	2	7			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:43923106C>T	uc010wka.1	+	1	834	c.834C>T	c.(832-834)GTC>GTT	p.V278V	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	278	Helical; (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		ACCACTTTGTCTATGTCACCA	0.592													6	136					0	0	0	0	T	43923106	T	T	43923106	2	4	139	1	0	0	0	0	0	0	0	1	7760	900	32	2		2	IMP5	17	43923106	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	2975272	43923106	37272104	193	25142											
XYLT2	64132	broad.mit.edu	37	chr17	48432263	48432263	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggagctggcccagggctatGataacgtgcgggtgacgccc	7	7	16	11	3	0	2	0	2	0	0	0	3	0	3	2	4	3	2	2	4	2	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:48432263G>C	uc002iqo.2	+	4	962	c.853G>C	c.(853-855)GAT>CAT	p.D285H	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	285	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					CCAGGGCTATGATAACGTGCG	0.642													7	86					0	0	0	0	C	48432263	C	C	48432263	3	2	139	1	0	0	0	0	1	0	0	0	17532	1290	45	2	867	2	XYLT2	17	48432263	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	4509157	48432263	32762947	194	25143											
ZNF750	79755	broad.mit.edu	37	chr17	80790225	80790226	+	Frame_Shift_Ins	INS	-	A	A																															ttaaaaagatgtgacttctcINSattgcaagtaaagggacatt																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr17:80790225_80790226insA	uc002kga.2	-	2	416_417	c.105_106insT	c.(103-108)AATGAGfs	p.N35fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	35_36						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGTGACTTCTCATTGCAAGTAA	0.411													---	---	---								A	80790226	A	A	80790225	7	5	139	1	0	1	1	0	0	0	0	0	18199	835	29	0	2073	0	ZNF750	17	80790225	Frame_Shift_Ins	INS	-	TCGA-CR-7368-01A-11D-2129-08	32357962	80790225	404985	195	25144											
COLEC12	81035	broad.mit.edu	37	chr18	480723	480723	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaccaaaccgcttgtaaccGaaggattgcacctcctcctc	10	9	6	16	2	1	0	1	0	0	0	4	2	3	1	6	1	3	3	6	1	3	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr18:480723G>A	uc002kkm.2	-	2	257	c.42C>T	c.(40-42)TTC>TTT	p.F14F		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	14	Cytoplasmic (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GCTTGTAACCGAAGGATTGCA	0.552													12	49					0	0	0	0	A	480723	A	A	480723	2	1	139	1	0	0	0	0	0	0	0	1	3727	1049	37	1		1	COLEC12	18	480723	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08		480723	77596525	196	25145											
DSG2	1829	broad.mit.edu	37	chr18	29104495	29104495	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtaaaacaagctcaagttCagattcgtattttggatgtc	12	14	8	7	1	2	1	2	0	0	1	4	2	2	2	0	1	2	4	0	1	5	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr18:29104495C>T	uc002kwu.3	+	7	963	c.775C>T	c.(775-777)CAG>TAG	p.Q259*		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	259	Extracellular (Potential).|Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGCTCAAGTTCAGATTCGTAT	0.343													5	35					0	0	0	0	T	29104495	T	T	29104495	4	4	139	1	0	0	0	0	0	1	0	0	4799	827	29	2	801	2	DSG2	18	29104495	Nonsense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	28623772	29104495	48972753	197	25146											
CDH20	28316	broad.mit.edu	37	chr18	59221721	59221721	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggccaagctctacgaggcCgacatggacctgtgggcacc	8	6	13	14	2	1	0	0	0	1	0	1	3	1	1	4	4	2	2	4	4	2	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr18:59221721C>T	uc010dps.1	+	11	2211	c.2199C>T	c.(2197-2199)GCC>GCT	p.A733A	CDH20_uc002lif.2_Silent_p.A727A	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	733	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TCTACGAGGCCGACATGGACC	0.642													3	33					0	0	0	0	T	59221721	T	T	59221721	2	4	139	1	0	0	0	0	0	0	0	1	3121	639	23	1		1	CDH20	18	59221721	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	30117226	59221721	18855527	198	25147											
MAP2K2	5605	broad.mit.edu	37	chr19	4101137	4101137	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgaggatgttggagggcttCacatctggaggcggcaggct	8	8	17	8	2	2	0	1	0	1	0	2	4	2	3	0	7	0	4	0	7	0	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:4101137C>G	uc002lzk.2	-	6	839	c.585G>C	c.(583-585)GTG>GTC	p.V195V	MAP2K2_uc002lzj.2_Silent_p.V5V	NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	195	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGAGGGCTTCACATCTGGAG	0.662									Cardiofaciocutaneous_syndrome				6	13					0	0	0	0	G	4101137	G	G	4101137	2	3	139	1	0	0	0	0	0	0	0	1	9290	813	29	2		2	MAP2K2	19	4101137	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08		4101137	55027846	199	25148											
TMEM146	257062	broad.mit.edu	37	chr19	5754220	5754220	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagctggaattgactgcttcGttgataccccagccaggcac	9	9	10	13	1	0	2	0	2	0	0	1	3	0	3	3	2	4	4	3	2	2	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:5754220G>A	uc002mda.2	+	13	1303	c.1242G>A	c.(1240-1242)TCG>TCA	p.S414S	TMEM146_uc010duj.1_Silent_p.S72S	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	414	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGACTGCTTCGTTGATACCCC	0.453													41	88					0	0	0	0	A	5754220	A	A	5754220	2	1	139	1	0	0	0	0	0	0	0	1	16126	1132	40	1		1	TMEM146	19	5754220	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1653083	5754220	53374763	200	25149											
ACER1	125981	broad.mit.edu	37	chr19	6309843	6309843	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agaccaggcggatgaactggGacctggggaggaaggggctc	10	4	19	8	1	0	2	0	1	0	1	1	6	0	6	2	8	1	1	2	8	2	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:6309843G>A	uc002mel.2	-	4	431	c.353C>T	c.(352-354)TCC>TTC	p.S118F		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	118	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0						GATGAACTGGGACCTGGGGAG	0.617													6	32					0	0	0	0	A	6309843	A	A	6309843	3	1	139	1	0	0	0	0	1	0	0	0	138	1174	41	2	453	2	ACER1	19	6309843	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	555623	6309843	52819140	201	25150											
MYO1F	4542	broad.mit.edu	37	chr19	8618294	8618294	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatgatatatttggctgcCactgtcttcccagctccact	7	13	6	15	0	1	1	0	1	1	0	3	1	3	1	4	1	2	2	4	1	2	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:8618294C>G	uc002mkg.2	-	5	468	c.354G>C	c.(352-354)GTG>GTC	p.V118V	MYO1F_uc002mkh.2_Silent_p.V118V|MYO1F_uc010xkf.1_Silent_p.V118V	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	118	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						ATTTGGCTGCCACTGTCTTCC	0.512													6	87					0	0	0	0	G	8618294	G	G	8618294	2	3	139	1	0	0	0	0	0	0	0	1	10126	581	21	4		4	MYO1F	19	8618294	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	2308451	8618294	50510689	202	25151											
ZNF266	10781	broad.mit.edu	37	chr19	9528555	9528555	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttcttgttccagccaagAgatcagactgggtttgaaga	10	12	10	9	0	3	4	1	1	2	3	4	5	4	4	2	1	1	2	2	1	2	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:9528555A>T	uc002mll.2	-	2	330	c.64T>A	c.(64-66)TCT>ACT	p.S22T	ZNF266_uc002mlm.2_Missense_Mutation_p.S22T|ZNF266_uc002mln.2_Missense_Mutation_p.S22T|ZNF266_uc002mlo.2_Missense_Mutation_p.S22T|ZNF266_uc010dwp.2_Missense_Mutation_p.S22T|ZNF266_uc010dwq.2_Missense_Mutation_p.S22T	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	22	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCCAGCCAAGAGATCAGACTG	0.438													61	111					0	0	0	0	T	9528555	T	T	9528555	3	4	139	1	0	0	0	0	1	0	0	0	17872	304	11	5	1597	5	ZNF266	19	9528555	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	910261	9528555	49600428	203	25152											
DNM2	1785	broad.mit.edu	37	chr19	10893634	10893635	+	Splice_Site	INS	-	GGCTACATT	GGCTACATT																															cctgactgcctctccccacaINSggctacattggcgtggtgaa																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:10893634_10893635insGGCTACATT	uc002mps.1	+	6	853	c.689_splice	c.e6-1	p.G230_splice	DNM2_uc010dxk.2_Splice_Site|DNM2_uc002mpt.1_Splice_Site_p.G230_splice|DNM2_uc002mpv.1_Splice_Site_p.G230_splice|DNM2_uc002mpu.1_Splice_Site_p.G230_splice|DNM2_uc010dxl.1_Splice_Site_p.G230_splice|DNM2_uc002mpw.2_5'Flank	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2						G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CTCTCCCCACAGGCTACATTGG	0.574													---	---	---								GGCTACATT	10893635	GGCTACATT	GGCTACATT	10893634	8	5	139	1	0	1	1	0	0	0	1	0	4694	202	7	0	709	0	DNM2	19	10893634	Splice_Site	INS	-	TCGA-CR-7368-01A-11D-2129-08	1365079	10893634	48235349	204	25153											
HOOK2	29911	broad.mit.edu	37	chr19	12878702	12878702	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcctcccgcaaggagtcccGctccgccaacagccgctgca	7	4	11	19	4	0	0	0	0	0	0	3	1	3	1	6	2	3	4	6	2	2	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:12878702G>A	uc002muy.2	-	13	1402	c.1231C>T	c.(1231-1233)CGG>TGG	p.R411W	HOOK2_uc010xmq.1_5'Flank|HOOK2_uc002muz.2_Missense_Mutation_p.R411W	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	411	Sufficient for interaction with microtubules.|Potential.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						AAGGAGTCCCGCTCCGCCAAC	0.677													21	22					0	0	0	0	A	12878702	A	A	12878702	3	1	139	1	0	0	0	0	1	0	0	0	7322	1086	38	1	972	1	HOOK2	19	12878702	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1985068	12878702	46250281	205	25154											
CYP4F8	11283	broad.mit.edu	37	chr19	15728925	15728925	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatcaacttgtgccaccctGacatcgtccgatctgtcatc	8	12	6	15	2	4	1	3	1	1	0	7	2	5	1	3	0	2	0	3	0	1	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:15728925G>C	uc002nbi.2	+	3	377	c.313G>C	c.(313-315)GAC>CAC	p.D105H	CYP4F8_uc010xoi.1_Missense_Mutation_p.D105H|CYP4F8_uc010xoj.1_Intron	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	105					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						GTGCCACCCTGACATCGTCCG	0.577													17	98					0	0	0	0	C	15728925	C	C	15728925	3	2	139	1	0	0	0	0	1	0	0	0	4208	1290	45	2	319	2	CYP4F8	19	15728925	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	2850223	15728925	43400058	206	25155											
C19orf2	8725	broad.mit.edu	37	chr19	30505952	30505952	+	Frame_Shift_Del	DEL	T	-	-																															agggtttcaaagtttaaagcTgccagattgcaacagaaaga																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:30505952delT	uc002nsr.2	+	11	1614	c.1584delT	c.(1582-1584)GCTfs	p.A528fs	C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_Frame_Shift_Del_p.A488fs|C19orf2_uc002nst.2_Frame_Shift_Del_p.A452fs	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	528					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		AGTTTAAAGCTGCCAGATTGC	0.413													---	---	---								-	30505952	-	-	30505952	7	5	139	1	0	1	0	1	0	0	0	0	1920	1567	55	0	1626	0	C19orf2	19	30505952	Frame_Shift_Del	DEL	T	TCGA-CR-7368-01A-11D-2129-08	14777027	30505952	28623031	207	25156											
FCGBP	8857	broad.mit.edu	37	chr19	40368715	40368715	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcagagcccgcacactgcGccatgatagctgctggggag	8	5	14	14	3	0	2	0	1	0	1	0	3	0	3	3	2	4	4	3	2	1	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:40368715G>A	uc002omp.3	-	28	12641	c.12633C>T	c.(12631-12633)GGC>GGT	p.G4211G		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4211	VWFD 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CGCACACTGCGCCATGATAGC	0.597													31	348					0	0	0	0	A	40368715	A	A	40368715	2	1	139	1	0	0	0	0	0	0	0	1	5810	1074	38	1		1	FCGBP	19	40368715	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	9862763	40368715	18760268	208	25157											
TSKS	60385	broad.mit.edu	37	chr19	50266447	50266447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccacccccgtgggggtgtCcccggcctcatggatctctt	3	10	11	17	2	2	0	1	0	1	0	5	1	4	1	6	4	0	0	6	4	0	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:50266447C>T	uc002ppm.2	-	1	69	c.58G>A	c.(58-60)GAC>AAC	p.D20N		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	20							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GTGGGGGTGTCCCCGGCCTCA	0.657													16	74					0	0	0	0	T	50266447	T	T	50266447	3	4	139	1	0	0	0	0	1	0	0	0	16693	855	30	2	1764	2	TSKS	19	50266447	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	9897732	50266447	8862536	209	25158											
RDH13	112724	broad.mit.edu	37	chr19	55559839	55559839	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaacatgggccagggacgaGaggttgatgatccgcgaagg	11	5	17	8	3	0	3	0	2	0	1	1	6	1	4	2	4	1	2	2	4	2	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:55559839G>C	uc002qio.3	-	5	701	c.516C>G	c.(514-516)CTC>CTG	p.L172L	RDH13_uc002qip.2_Silent_p.L101L|RDH13_uc010esr.1_RNA	NM_001145971	NP_001139443	Q8NBN7	RDH13_HUMAN	retinol dehydrogenase 13 isoform 1	172							binding|oxidoreductase activity			large_intestine(1)|ovary(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(297;0.199)	GBM - Glioblastoma multiforme(193;0.0504)	Vitamin A(DB00162)	CCAGGGACGAGAGGTTGATGA	0.512													5	67					0	0	0	0	C	55559839	C	C	55559839	2	2	139	1	0	0	0	0	0	0	0	1	13257	929	33	2		2	RDH13	19	55559839	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	5293392	55559839	3569144	210	25159											
ZNF211	10520	broad.mit.edu	37	chr19	58152803	58152803	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggccttatgcgtgccctGaatgtgggaaatcgtttagt	10	12	12	7	2	0	1	0	1	0	0	1	2	0	2	2	2	2	1	2	2	5	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:58152803G>A	uc002qpq.2	+	3	1129	c.949G>A	c.(949-951)GAA>AAA	p.E317K	ZNF211_uc010yhb.1_Missense_Mutation_p.E321K|ZNF211_uc002qpp.2_Missense_Mutation_p.E330K|ZNF211_uc002qpr.2_Missense_Mutation_p.E381K|ZNF211_uc002qps.2_Missense_Mutation_p.E382K|ZNF211_uc002qpt.2_Missense_Mutation_p.E329K|ZNF211_uc010yhc.1_Missense_Mutation_p.E329K|ZNF211_uc010yhd.1_Missense_Mutation_p.E256K|ZNF211_uc010yhe.1_Missense_Mutation_p.E308K	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	317	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGCGTGCCCTGAATGTGGGAA	0.408													18	79					0	0	0	0	A	58152803	A	A	58152803	3	1	139	1	0	0	0	0	1	0	0	0	17834	1291	45	2	1002	2	ZNF211	19	58152803	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	2592964	58152803	976180	211	25160											
ZNF274	10782	broad.mit.edu	37	chr19	58697098	58697098	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaccagtgacctttgaagAtgtaacactgggttttaccc	11	11	10	9	0	0	3	0	2	0	1	0	4	0	4	3	2	3	2	3	2	4	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr19:58697098A>T	uc002qrq.1	+	3	512	c.53A>T	c.(52-54)GAT>GTT	p.D18V	ZNF274_uc010yhu.1_RNA|ZNF274_uc010yhv.1_Intron|ZNF274_uc002qrr.1_Missense_Mutation_p.D18V|ZNF274_uc002qrs.1_Intron|ZNF274_uc010eum.1_5'UTR	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	18	KRAB 1.				viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		ACCTTTGAAGATGTAACACTG	0.517													42	65					0	0	0	0	T	58697098	T	T	58697098	3	4	139	1	0	0	0	0	1	0	0	0	17876	333	12	5	59	5	ZNF274	19	58697098	Missense_Mutation	SNP	A	TCGA-CR-7368-01A-11D-2129-08	544295	58697098	431885	212	25161											
SNX5	27131	broad.mit.edu	37	chr20	17937598	17937598	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgtgtgcactgtaaatttGactttgtctctctcactgag	7	18	8	8	0	2	2	1	2	2	0	4	2	2	2	0	0	1	2	0	0	2	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:17937598G>C	uc002wqc.2	-	2	221	c.135C>G	c.(133-135)GTC>GTG	p.V45V	SNX5_uc002wqb.2_RNA|SNX5_uc002wqd.2_Silent_p.V45V|SNX5_uc002wqe.2_5'UTR|SNX5_uc010zrt.1_Silent_p.V45V	NM_014426	NP_055241	Q9Y5X3	SNX5_HUMAN	sorting nexin 5	45	Phosphatidylinositol bisphosphate binding (By similarity).|PX.				cell communication|pinocytosis|protein transport	cytoplasmic vesicle membrane|early endosome membrane|extrinsic to endosome membrane|extrinsic to internal side of plasma membrane|macropinocytic cup|phagocytic cup|ruffle	phosphatidylinositol binding			large_intestine(1)	1						CTGTAAATTTGACTTTGTCTC	0.423													16	57					0	0	0	0	C	17937598	C	C	17937598	2	2	139	1	0	0	0	0	0	0	0	1	14969	1277	45	2		2	SNX5	20	17937598	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08		17937598	45087922	213	25162											
ACSS1	84532	broad.mit.edu	37	chr20	25038407	25038407	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcccgaagcccactcaccaGagacatttaactggcctccc	10	7	6	18	1	1	1	1	0	0	1	3	3	3	1	5	1	2	0	5	1	2	2	rs141662914		TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:25038407G>A	uc002wub.2	-	1	1210	c.332C>T	c.(331-333)TCT>TTT	p.S111F	ACSS1_uc002wuc.2_Missense_Mutation_p.S111F|ACSS1_uc010gdc.2_Missense_Mutation_p.S111F	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	111					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCACTCACCAGAGACATTTAA	0.667													7	47					0	0	0	0	A	25038407	A	A	25038407	3	1	139	1	0	0	0	0	1	0	0	0	188	942	33	2	1793	2	ACSS1	20	25038407	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	7100809	25038407	37987113	214	25163											
NANP	140838	broad.mit.edu	37	chr20	25604531	25604531	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgctcgccccggccgtgtcGatgagagtgttgtccaagtc	5	10	13	13	4	0	1	0	1	0	1	4	3	1	1	4	1	1	2	4	1	1	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:25604531G>A	uc002wuy.2	-	1	118	c.54C>T	c.(52-54)ATC>ATT	p.I18I	uc002wuz.2_5'Flank	NM_152667	NP_689880	Q8TBE9	NANP_HUMAN	N-acetylneuraminic acid phosphatase	18					N-acetylneuraminate biosynthetic process		N-acylneuraminate-9-phosphatase activity|phosphoglycolate phosphatase activity				0						CGGCCGTGTCGATGAGAGTGT	0.701													4	26					0	0	0	0	A	25604531	A	A	25604531	2	1	139	1	0	0	0	0	0	0	0	1	10207	1048	37	1		1	NANP	20	25604531	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	566124	25604531	37420989	215	25164											
ITCH	83737	broad.mit.edu	37	chr20	33045206	33045206	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcccaaagagaagagaacaGacagcaatggcagagtatat	18	6	10	7	0	0	4	0	0	0	4	1	6	1	4	1	1	2	3	1	1	6	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:33045206G>A	uc010geu.1	+	14	1537	c.1345G>A	c.(1345-1347)GAC>AAC	p.D449N	ITCH_uc002xak.2_Missense_Mutation_p.D408N|ITCH_uc010zuj.1_Missense_Mutation_p.D298N	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	449	WW 3.|Required for interaction with FYN.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						GAAGAGAACAGACAGCAATGG	0.403													4	20					0	0	0	0	A	33045206	A	A	33045206	3	1	139	1	0	0	0	0	1	0	0	0	7907	942	33	2	1264	2	ITCH	20	33045206	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	7440675	33045206	29980314	216	25165											
ADIG	149685	broad.mit.edu	37	chr20	37209995	37209995	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgttgttattgatcatctgGctacgcttcttacttagcca	7	17	7	10	1	3	1	1	1	2	0	3	1	3	1	1	1	3	4	1	1	4	7			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:37209995G>A	uc002xjb.1	+	1	158	c.102G>A	c.(100-102)TGG>TGA	p.W34*		NM_001018082	NP_001018092	Q0VDE8	ADIG_HUMAN	small adipocyte factor 1	34	Helical; (Potential).				brown fat cell differentiation|positive regulation of fat cell differentiation|white fat cell differentiation	cytoplasm|integral to membrane|nucleus					0		Myeloproliferative disorder(115;0.00878)				TGATCATCTGGCTACGCTTCT	0.517													40	49					0	0	0	0	A	37209995	A	A	37209995	4	1	139	1	0	0	0	0	0	1	0	0	316	1212	42	4	104	4	ADIG	20	37209995	Nonsense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	4164789	37209995	25815525	217	25166											
MAFB	9935	broad.mit.edu	37	chr20	39316788	39316788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcttcaggcggatcacctCgtccttggtgaagccccgca	6	9	11	15	3	2	1	2	1	0	0	4	2	3	2	4	3	2	2	4	3	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:39316788C>T	uc002xji.2	-	1	1089	c.703G>A	c.(703-705)GAG>AAG	p.E235K		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	235					negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				CGGATCACCTCGTCCTTGGTG	0.612			T	IGH@	MM								5	12					0	0	0	0	T	39316788	T	T	39316788	3	4	139	1	0	0	0	0	1	0	0	0	9209	893	31	1	272	1	MAFB	20	39316788	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	2106793	39316788	23708732	218	25167											
ZNF334	55713	broad.mit.edu	37	chr20	45130984	45130985	+	Frame_Shift_Ins	INS	-	A	A																															tcagccagggctgacttccgINSaaaaaaggtctttccacatt																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:45130984_45130985insA	uc002xsc.2	-	5	1177_1178	c.993_994insT	c.(991-996)TTTCGGfs	p.F331fs	ZNF334_uc002xsa.2_Frame_Shift_Ins_p.F354fs|ZNF334_uc002xsb.2_Frame_Shift_Ins_p.F293fs|ZNF334_uc002xsd.2_Frame_Shift_Ins_p.F293fs|ZNF334_uc010ghl.2_Frame_Shift_Ins_p.F330fs	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	331_332	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				GCTGACTTCCGAAAAAAGGTCT	0.436													---	---	---								A	45130985	A	A	45130984	7	5	139	1	0	1	1	0	0	0	0	0	17918	1057	37	0	1052	0	ZNF334	20	45130984	Frame_Shift_Ins	INS	-	TCGA-CR-7368-01A-11D-2129-08	5814196	45130984	17894536	219	25168											
ZNFX1	57169	broad.mit.edu	37	chr20	47863847	47863847	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caaagttcatcaggttgttgGccgtgtcagaccaggcagca	10	9	12	10	1	3	1	3	0	0	1	3	1	3	1	2	3	1	5	2	3	1	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:47863847G>A	uc002xui.2	-	14	5961	c.5714C>T	c.(5713-5715)GCC>GTC	p.A1905V		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1905							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CAGGTTGTTGGCCGTGTCAGA	0.522													30	64					0	0	0	0	A	47863847	A	A	47863847	3	1	139	1	0	0	0	0	1	0	0	0	18272	1203	42	4	46	4	ZNFX1	20	47863847	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	2732863	47863847	15161673	220	25169											
BMP7	655	broad.mit.edu	37	chr20	55840910	55840910	+	Frame_Shift_Del	DEL	A	-	-																															cgccgccctcctccaccgccAtggcgttgtacaggtccagc																										TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:55840910delA	uc010gip.1	-	1	798	c.269delT	c.(268-270)ATGfs	p.M90fs	BMP7_uc010giq.1_Frame_Shift_Del_p.M90fs|BMP7_uc002xyc.2_Frame_Shift_Del_p.M90fs|uc010gir.1_5'Flank	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor	90					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			CTCCACCGCCATGGCGTTGTA	0.672													---	---	---								-	55840910	-	-	55840910	7	5	139	1	0	1	0	1	0	0	0	0	1468	217	8	0	1054	0	BMP7	20	55840910	Frame_Shift_Del	DEL	A	TCGA-CR-7368-01A-11D-2129-08	7977063	55840910	7184610	221	25170											
MYT1	4661	broad.mit.edu	37	chr20	62871203	62871203	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctgtttctggagctgtccGgcctgagccaggccctcatc	4	10	11	16	1	2	1	1	1	1	0	4	2	3	2	5	3	2	2	5	3	0	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr20:62871203G>T	uc002yii.2	+	22	3548	c.3184G>T	c.(3184-3186)GGC>TGC	p.G1062C	MYT1_uc002yij.2_Missense_Mutation_p.G721C|MYT1_uc002yik.2_Missense_Mutation_p.G28C	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1062					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GGAGCTGTCCGGCCTGAGCCA	0.592													19	119					7.41877e-09	7.89185e-09	1	0	T	62871203	T	T	62871203	3	4	139	1	0	0	0	0	1	0	0	0	10159	1116	39	3	3262	3	MYT1	20	62871203	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	7030293	62871203	154317	222	25171											
GABPA	2551	broad.mit.edu	37	chr21	27136626	27136626	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaagagcgccgaggatttCaggagaagatagaagctcac	16	5	12	8	2	2	4	2	0	0	4	2	7	2	5	1	2	2	1	1	2	4	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr21:27136626C>T	uc002ylx.3	+	8	1435	c.908C>T	c.(907-909)TCA>TTA	p.S303L	GABPA_uc002yly.3_Missense_Mutation_p.S303L	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	303					positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						CCGAGGATTTCAGGAGAAGAT	0.338													16	24					0	0	0	0	T	27136626	T	T	27136626	3	4	139	1	0	0	0	0	1	0	0	0	6191	838	29	2	934	2	GABPA	21	27136626	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08		27136626	20993269	223	25172											
KRTAP13-2	337959	broad.mit.edu	37	chr21	31744345	31744345	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggacgtctggcagctggtggGctcccagcagatctcctgac	6	8	14	13	1	2	2	0	1	2	1	4	3	3	3	2	4	2	4	2	4	0	0			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr21:31744345G>A	uc002ynz.3	-	1	213	c.187C>T	c.(187-189)CCC>TCC	p.P63S		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	63	5 X 10 AA approximate repeats.|2.					intermediate filament					0						CAGCTGGTGGGCTCCCAGCAG	0.602													23	43					0	0	0	0	A	31744345	A	A	31744345	3	1	139	1	0	0	0	0	1	0	0	0	8562	1203	42	4	344	4	KRTAP13-2	21	31744345	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	4607719	31744345	16385550	224	25173											
ZNF280A	129025	broad.mit.edu	37	chr22	22869589	22869589	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagctcattttataaccaggTtcagatgaagacttcatagt	13	13	8	7	0	3	3	3	1	0	2	3	4	3	3	1	1	2	2	1	1	4	6			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr22:22869589T>C	uc002zwe.2	-	2	619	c.366A>G	c.(364-366)GAA>GAG	p.E122E	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	122					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TATAACCAGGTTCAGATGAAG	0.483													35	51					0	0	0	0	C	22869589	C	C	22869589	2	2	139	1	0	0	0	0	0	0	0	1	17881	1722	60	5		5	ZNF280A	22	22869589	Silent	SNP	T	TCGA-CR-7368-01A-11D-2129-08		22869589	28434977	225	25174											
TST	7263	broad.mit.edu	37	chr22	37407100	37407100	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agactttccctgggacacacGgctctctgggggggcccggc	5	7	15	14	2	1	1	0	0	1	1	3	2	2	2	2	6	0	1	2	6	0	1	rs148918180	by1000genomes	TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr22:37407100G>A	uc003aqg.2	-	2	1562	c.862C>T	c.(862-864)CGT>TGT	p.R288C	TST_uc003aqh.2_Missense_Mutation_p.R288C	NM_003312	NP_003303	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase	288	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity				0						TGGGACACACGGCTCTCTGGG	0.617													5	103					0	0	0	0	A	37407100	A	A	37407100	3	1	139	1	0	0	0	0	1	0	0	0	16740	1116	39	1	35	1	TST	22	37407100	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08	14537511	37407100	13897466	226	25175											
MICALL1	85377	broad.mit.edu	37	chr22	38323542	38323542	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcagagcttctggagccGccagctgtgcccaagagctc	7	7	14	13	1	1	2	0	0	1	2	2	3	1	3	3	2	6	4	3	2	1	1	rs138192828		TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr22:38323542G>A	uc003aui.2	+	9	1674	c.1590G>A	c.(1588-1590)CCG>CCA	p.P530P		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	530	Pro-rich.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					TTCTGGAGCCGCCAGCTGTGC	0.657													33	53					0	0	0	0	A	38323542	A	A	38323542	2	1	139	1	0	0	0	0	0	0	0	1	9626	1074	38	1		1	MICALL1	22	38323542	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	916442	38323542	12981024	227	25176											
APOBEC3H	164668	broad.mit.edu	37	chr22	39497505	39497505	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccggtggaggtcatgggcttCccaagtaggaaagaggcttt	9	9	15	8	1	1	1	1	0	0	1	2	3	2	3	2	6	0	3	2	6	3	3			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chr22:39497505C>T	uc011aoh.1	+	3	480	c.414C>T	c.(412-414)TTC>TTT	p.F138F	APOBEC3H_uc011aoi.1_5'Flank|APOBEC3H_uc003axa.3_5'Flank	NM_181773	NP_861438	Q6NTF7	ABC3H_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	138					DNA cytosine deamination|negative regulation of retroviral genome replication|negative regulation of transposition	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Melanoma(58;0.04)					TCATGGGCTTCCCAAGTAGGA	0.493													13	47					0	0	0	0	T	39497505	T	T	39497505	2	4	139	1	0	0	0	0	0	0	0	1	795	854	30	2		2	APOBEC3H	22	39497505	Silent	SNP	C	TCGA-CR-7368-01A-11D-2129-08	1173963	39497505	11807061	228	25177											
PPP2R3B	28227	broad.mit.edu	37	chrX	306382	306382	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtcagctggttgatgtccGcctcctcctccagcagcgcc	4	9	11	17	3	1	1	1	1	0	0	5	1	5	1	6	2	3	3	6	2	0	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:306382G>A	uc004cpg.2	-	7	1106	c.905C>T	c.(904-906)GCG>GTG	p.A302V	PPP2R3B_uc011mha.1_Missense_Mutation_p.A141V	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	302					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTTGATGTCCGCCTCCTCCTC	0.637													19	45					0	0	0	0	A	306382	A	A	306382	3	1	139	1	0	0	0	0	1	0	0	0	12449	1087	38	1	850	1	PPP2R3B	23	306382	Missense_Mutation	SNP	G	TCGA-CR-7368-01A-11D-2129-08		306382	154964178	229	25178											
CSF2RA	1438	broad.mit.edu	37	chrX	1407734	1407734	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtacctgggcgaggggtccGacggccccccgtgacgtcca	5	6	15	15	5	0	1	0	1	0	0	2	3	2	1	6	4	1	1	6	4	1	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:1407734G>A	uc010nct.2	+	7	748	c.426G>A	c.(424-426)CCG>CCA	p.P142P	CSF2RA_uc011mhb.1_Silent_p.P142P|CSF2RA_uc004cpq.2_Silent_p.P142P|CSF2RA_uc004cpn.2_Silent_p.P142P|CSF2RA_uc004cpo.2_Silent_p.P142P|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Silent_p.P9P|CSF2RA_uc004cpp.2_Silent_p.P142P|CSF2RA_uc010ncv.2_Silent_p.P142P|CSF2RA_uc004cpr.2_Silent_p.P142P	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	142	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CGAGGGGTCCGACGGCCCCCC	0.478													53	68					0	0	0	0	A	1407734	A	A	1407734	2	1	139	1	0	0	0	0	0	0	0	1	3951	1045	37	1		1	CSF2RA	23	1407734	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	1101352	1407734	153862826	230	25179											
PIGA	5277	broad.mit.edu	37	chrX	15349714	15349714	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccgaacaaatatgtacctGagcaatggcagactgtgaaa	15	8	9	9	1	0	3	0	2	0	1	1	4	1	3	2	1	3	3	2	1	6	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:15349714G>A	uc004cwr.2	-	2	439	c.339C>T	c.(337-339)CTC>CTT	p.L113L	PIGA_uc004cwq.2_5'UTR|PIGA_uc010nev.2_Silent_p.L113L|PIGA_uc004cws.2_Intron|PIGA_uc011miq.1_Intron|PIGA_uc010new.1_Silent_p.L113L	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	113	Cytoplasmic (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)					ATATGTACCTGAGCAATGGCA	0.478													43	10					0	0	0	0	A	15349714	A	A	15349714	2	1	139	1	0	0	0	0	0	0	0	1	11939	1277	45	2		2	PIGA	23	15349714	Silent	SNP	G	TCGA-CR-7368-01A-11D-2129-08	13941980	15349714	139920846	231	25180											
SH3KBP1	30011	broad.mit.edu	37	chrX	19568091	19568091	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagtttgaggagacacttaCagatgtgagggactgggacg	12	8	15	6	1	0	4	0	2	0	2	0	7	0	6	0	3	1	1	0	3	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:19568091C>T	uc004czm.2	-	14	1810	c.1494_splice	c.e14+1	p.S498_splice	SH3KBP1_uc011mje.1_Splice_Site_p.S237_splice|SH3KBP1_uc011mjf.1_Splice_Site_p.S260_splice|SH3KBP1_uc004czl.2_Splice_Site_p.S461_splice|SH3KBP1_uc010nfm.2_Splice_Site	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a						apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						GAGACACTTACAGATGTGAGG	0.488													5	74					0	0	0	0	T	19568091	T	T	19568091	5	4	139	1	0	0	0	0	0	0	1	0	14320	492	17	4	522	4	SH3KBP1	23	19568091	Splice_Site	SNP	C	TCGA-CR-7368-01A-11D-2129-08	4218377	19568091	135702469	232	25181											
SAT1	6303	broad.mit.edu	37	chrX	23803928	23803928	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagagggttggagactgttCaagatcgacaaggagtactt	13	9	14	5	1	1	3	1	0	0	3	2	7	1	4	0	3	1	3	0	3	4	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:23803928C>A	uc004dau.2	+	6	665	c.471C>A	c.(469-471)TTC>TTA	p.F157L	SAT1_uc004dav.2_RNA	NM_002970	NP_002961	P21673	SAT1_HUMAN	diamine N-acetyltransferase 1	157	N-acetyltransferase.				angiogenesis|polyamine biosynthetic process	cytosol	diamine N-acetyltransferase activity|protein binding				0					Spermine(DB00127)	GGAGACTGTTCAAGATCGACA	0.423													17	15					1.40151e-16	1.53088e-16	1	0	A	23803928	A	A	23803928	3	1	139	1	0	0	0	0	1	0	0	0	13916	825	29	2	493	2	SAT1	23	23803928	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	4235837	23803928	131466632	233	25182											
KDM6A	7403	broad.mit.edu	37	chrX	44870205	44870205	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttttcccttcctttacaGaatgctgcctttttatatgg	6	20	5	10	0	1	1	0	0	1	1	3	1	3	1	3	1	3	1	3	1	4	9			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:44870205G>A	uc004dge.3	+	5	760	c.385_splice	c.e5-1	p.N129_splice	KDM6A_uc010nhk.2_Splice_Site_p.N129_splice|KDM6A_uc011mkz.1_Splice_Site_p.N129_splice|KDM6A_uc011mla.1_Splice_Site_p.N129_splice|KDM6A_uc011mlb.1_Splice_Site_p.N129_splice|KDM6A_uc011mlc.1_Splice_Site	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TTCCTTTACAGAATGCTGCCT	0.299			D|N|F|S		renal|oesophageal SCC|MM								5	6					0	0	0	0	A	44870205	A	A	44870205	5	1	139	1	0	0	0	0	0	0	1	0	8176	956	33	2	402	2	KDM6A	23	44870205	Splice_Site	SNP	G	TCGA-CR-7368-01A-11D-2129-08	21066277	44870205	110400355	234	25183											
MTMR8	55613	broad.mit.edu	37	chrX	63555987	63555987	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacttgtggcccatggataTccattccttctctatcaaga	11	13	6	11	0	2	1	1	0	1	1	5	2	4	2	3	2	1	0	3	2	4	5			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:63555987T>A	uc004dvs.2	-	10	1191	c.1123A>T	c.(1123-1125)ATA>TTA	p.I375L	MTMR8_uc011mou.1_Intron|MTMR8_uc004dvt.1_Missense_Mutation_p.I375L	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	375	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						CCCATGGATATCCATTCCTTC	0.338													33	10					0	0	0	0	A	63555987	A	A	63555987	3	1	139	1	0	0	0	0	1	0	0	0	10002	1435	50	5	1011	5	MTMR8	23	63555987	Missense_Mutation	SNP	T	TCGA-CR-7368-01A-11D-2129-08	18685782	63555987	91714573	235	25184											
IGSF1	3547	broad.mit.edu	37	chrX	130412064	130412064	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccggagttgtagttcctggcCccggattgtgggggaagcag	6	9	17	9	2	0	0	0	0	0	0	1	3	1	3	4	5	1	4	4	5	2	4			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:130412064C>T	uc004ewd.2	-	13	2324	c.2086G>A	c.(2086-2088)GGC>AGC	p.G696S	IGSF1_uc004ewe.3_Missense_Mutation_p.G690S|IGSF1_uc004ewf.2_Missense_Mutation_p.G676S	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	696	Extracellular (Potential).|Ig-like C2-type 7.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						AGTTCCTGGCCCCGGATTGTG	0.532													37	18					0	0	0	0	T	130412064	T	T	130412064	3	4	139	1	0	0	0	0	1	0	0	0	7635	623	22	4	1956	4	IGSF1	23	130412064	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	66856077	130412064	24858496	236	25185											
ZNF75D	7626	broad.mit.edu	37	chrX	134426280	134426280	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtagtacccggtatgtattCcaatattctttctggaacac	10	15	7	9	1	2	0	0	0	2	0	3	1	3	1	2	2	2	4	2	2	7	8			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:134426280C>T	uc004eyp.2	-	4	3186	c.531G>A	c.(529-531)TGG>TGA	p.W177*	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'UTR|ZNF75D_uc004eyo.2_Intron	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	177					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGTATGTATTCCAATATTCTT	0.498													5	77					0	0	0	0	T	134426280	T	T	134426280	4	4	139	1	0	0	0	0	0	1	0	0	18201	856	30	2	1017	2	ZNF75D	23	134426280	Nonsense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	4014216	134426280	20844280	237	25186											
LDOC1	23641	broad.mit.edu	37	chrX	140270912	140270912	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccacccactcctcggcttCcccggtgaggaggctgatta	7	8	10	16	2	0	2	0	2	0	0	3	3	2	3	5	4	0	2	5	4	1	2			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:140270912C>T	uc004fbj.2	-	1	399	c.295G>A	c.(295-297)GAA>AAA	p.E99K		NM_012317	NP_036449	O95751	LDOC1_HUMAN	leucine zipper, down-regulated in cancer 1	99					negative regulation of cell proliferation	nucleus	protein binding				0	Acute lymphoblastic leukemia(192;7.65e-05)					TCCTCGGCTTCCCCGGTGAGG	0.552													38	24					0	0	0	0	T	140270912	T	T	140270912	3	4	139	1	0	0	0	0	1	0	0	0	8749	864	30	2	149	2	LDOC1	23	140270912	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	5844632	140270912	14999648	238	25187											
CXorf40B	541578	broad.mit.edu	37	chrX	149101932	149101932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctctccaccagcagctccCgacaggcatcgccttcccag	7	7	8	19	2	1	0	0	0	1	0	6	1	4	0	5	1	2	3	5	1	0	1			TCGA-CR-7368-01A-11D-2129-08	TCGA-CR-7368-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	4b194ab3-d213-4a7a-be46-909b4f0c7291	2f1b122e-205d-44be-a6e1-1fc7f2271d99	g.chrX:149101932C>T	uc004fdy.2	-	4	677	c.161G>A	c.(160-162)CGG>CAG	p.R54Q	CXorf40B_uc011mxs.1_RNA	NM_001013845	NP_001013867	Q96DE9	CX04B_HUMAN	hypothetical protein LOC541578	54											0	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCAGCTCCCGACAGGCATC	0.587													45	24					0	0	0	0	T	149101932	T	T	149101932	3	4	139	1	0	0	0	0	1	0	0	0	4126	652	23	1	323	1	CXorf40B	23	149101932	Missense_Mutation	SNP	C	TCGA-CR-7368-01A-11D-2129-08	8831020	149101932	6168628	239	25188											
CASZ1	54897	broad.mit.edu	37	chr1	10715709	10715710	+	Frame_Shift_Ins	INS	-	A	A																															cgggtgcgggaggcacctgcINSatgcagtgatagtgggtgct																										TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:10715709_10715710insA	uc001aro.2	-	9	1981_1982	c.1661_1662insT	c.(1660-1662)ATGfs	p.M554fs	CASZ1_uc001arp.1_Frame_Shift_Ins_p.M554fs|CASZ1_uc009vmx.2_Frame_Shift_Ins_p.M578fs	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	554	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GAGGCACCTGCATGCAGTGATA	0.678													---	---	---								A	10715710	A	A	10715709	7	5	140	1	0	1	1	0	0	0	0	0	2697	710	25	0	3673	0	CASZ1	1	10715709	Frame_Shift_Ins	INS	-	TCGA-CR-7369-01A-11D-2129-08		10715709	238534912	1	25189											
CASZ1	54897	broad.mit.edu	37	chr1	10720212	10720212	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcatctggacactgctgtgcGacggcaggggcaggatggtg	7	7	18	9	2	1	0	0	0	1	0	1	3	1	2	0	6	2	4	0	6	0	0			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:10720212G>A	uc001aro.2	-	6	1207	c.887C>T	c.(886-888)TCG>TTG	p.S296L	CASZ1_uc001arp.1_Missense_Mutation_p.S296L|CASZ1_uc009vmx.2_Missense_Mutation_p.S320L|CASZ1_uc001arq.1_Missense_Mutation_p.S155L	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		ACTGCTGTGCGACGGCAGGGG	0.657													85	68					0	0	0	0	A	10720212	A	A	10720212	3	1	140	1	0	0	0	0	1	0	0	0	2697	1059	37	1	4460	1	CASZ1	1	10720212	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	4503	10720212	238530409	2	25190											
PRDM2	7799	broad.mit.edu	37	chr1	14075948	14075948	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggaagagcgagccagcgcCcggagcaagcggagctcccc	10	1	16	14	4	0	1	0	0	0	1	1	6	1	4	4	3	6	2	4	3	2	0			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:14075948C>A	uc001avi.2	+	6	1333	c.477C>A	c.(475-477)GCC>GCA	p.A159A	PRDM2_uc001avg.2_Silent_p.A159A|PRDM2_uc001avh.2_Silent_p.A159A|PRDM2_uc001avj.2_RNA|PRDM2_uc009vod.1_5'UTR|PRDM2_uc001avk.2_5'UTR|PRDM2_uc009voe.2_RNA|PRDM2_uc009vof.2_RNA	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	159				A->V: Reduced histone methyltransferase activity.		Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GAGCCAGCGCCCGGAGCAAGC	0.453													8	13					2.17888e-05	2.28465e-05	1	0	A	14075948	A	A	14075948	2	1	140	1	0	0	0	0	0	0	0	1	12520	610	22	4		4	PRDM2	1	14075948	Silent	SNP	C	TCGA-CR-7369-01A-11D-2129-08	3355736	14075948	235174673	3	25191											
RNF19B	127544	broad.mit.edu	37	chr1	33402524	33402524	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctctgggggtcgaggggcaGgctgcagtatgggagcgggg	5	6	23	7	2	1	0	0	0	1	0	2	2	1	1	0	8	2	5	0	8	1	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:33402524G>A	uc010oho.1	-	9	2082	c.2082C>T	c.(2080-2082)GCC>GCT	p.A694A	RNF19B_uc001bwm.3_3'UTR|RNF19B_uc010ohp.1_Silent_p.A693A	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	694						integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TCGAGGGGCAGGCTGCAGTAT	0.587													41	117					0	0	0	0	A	33402524	A	A	33402524	2	1	140	1	0	0	0	0	0	0	0	1	13536	987	35	4		4	RNF19B	1	33402524	Silent	SNP	G	TCGA-CR-7369-01A-11D-2129-08	19326576	33402524	215848097	4	25192											
GBP3	2635	broad.mit.edu	37	chr1	89481070	89481070	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccagattcctttggtgtgaGatttcactgtggagcccaga	8	13	11	9	0	1	3	1	1	0	3	3	5	3	4	3	2	1	0	3	2	0	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:89481070G>C	uc001dmt.2	-	3	423	c.218C>G	c.(217-219)TCT>TGT	p.S73C	GBP3_uc010oss.1_Translation_Start_Site|GBP3_uc001dmu.2_Translation_Start_Site|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	73						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		TTTGGTGTGAGATTTCACTGT	0.483													33	98					0	0	0	0	C	89481070	C	C	89481070	3	2	140	1	0	0	0	0	1	0	0	0	6310	942	33	2	1605	2	GBP3	1	89481070	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	56078546	89481070	159769551	5	25193											
BTBD8	284697	broad.mit.edu	37	chr1	92604948	92604948	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttatgatgcattttatatAtggaggaactctggacattc	11	16	9	5	0	1	1	0	1	1	0	2	4	1	4	0	3	2	2	0	3	5	6			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:92604948A>G	uc001doo.2	+	6	1061	c.794A>G	c.(793-795)TAT>TGT	p.Y265C	BTBD8_uc010otc.1_RNA	NM_183242	NP_899065	Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	265	BTB 2.					nucleus				ovary(1)	1		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		CATTTTATATATGGAGGAACT	0.294													22	97					0	0	0	0	G	92604948	G	G	92604948	3	3	140	1	0	0	0	0	1	0	0	0	1552	449	16	5	816	5	BTBD8	1	92604948	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08	3123878	92604948	156645673	6	25194											
FNDC7	163479	broad.mit.edu	37	chr1	109270438	109270438	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgctttcagctccctgtTgtcctagtgacattaacccc	6	14	6	15	0	1	1	1	1	0	0	4	1	4	1	5	0	3	3	5	0	2	4			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:109270438T>C	uc001dvx.2	+	7	1120	c.1120T>C	c.(1120-1122)TGT>CGT	p.C374R	FNDC7_uc010ova.1_Missense_Mutation_p.C141R	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	375						extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		AGCTCCCTGTTGTCCTAGTGA	0.547													44	131					0	0	0	0	C	109270438	C	C	109270438	3	2	140	1	0	0	0	0	1	0	0	0	6005	1812	63	5	1146	5	FNDC7	1	109270438	Missense_Mutation	SNP	T	TCGA-CR-7369-01A-11D-2129-08	16665490	109270438	139980183	7	25195											
PDE4DIP	9659	broad.mit.edu	37	chr1	144923767	144923767	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agatacagactgctgagttaTagtggtctcatgtgaattca	12	13	10	6	0	2	4	2	2	1	2	3	4	2	4	0	1	2	2	0	1	4	4			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:144923767T>C	uc001elw.3	-	6	982	c.691A>G	c.(691-693)ATA>GTA	p.I231V	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.I297V|PDE4DIP_uc001emc.1_Missense_Mutation_p.I231V|PDE4DIP_uc001emd.1_Missense_Mutation_p.I231V|PDE4DIP_uc001emb.1_Missense_Mutation_p.I394V|PDE4DIP_uc001eme.1_5'Flank|PDE4DIP_uc001emf.1_Missense_Mutation_p.I18V	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	231					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGCTGAGTTATAGTGGTCTCA	0.448			T	PDGFRB	MPD								32	221					0	0	0	0	C	144923767	C	C	144923767	3	2	140	1	0	0	0	0	1	0	0	0	11697	1406	49	5	6515	5	PDE4DIP	1	144923767	Missense_Mutation	SNP	T	TCGA-CR-7369-01A-11D-2129-08	35653329	144923767	104326854	8	25196											
UBE2Q1	55585	broad.mit.edu	37	chr1	154524644	154524644	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggagatcgttgtgcaaagcGctgtcctggtcaactctaag	9	11	12	9	2	2	1	1	0	1	1	4	2	3	1	1	2	3	3	1	2	3	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:154524644G>A	uc001fff.1	-	8	982	c.891C>T	c.(889-891)AGC>AGT	p.S297S		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	297							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGTGCAAAGCGCTGTCCTGGT	0.493													18	98					0	0	0	0	A	154524644	A	A	154524644	2	1	140	1	0	0	0	0	0	0	0	1	16937	1078	38	1		1	UBE2Q1	1	154524644	Silent	SNP	G	TCGA-CR-7369-01A-11D-2129-08	9600877	154524644	94725977	9	25197											
PLA2G4A	5321	broad.mit.edu	37	chr1	186946794	186946794	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaagattgatccttatgtgTttgatcgggaagggctgaag	11	12	13	5	1	0	4	0	3	0	1	2	5	1	5	1	2	0	2	1	2	4	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:186946794T>A	uc001gsc.2	+	16	2039	c.1834T>A	c.(1834-1836)TTT>ATT	p.F612I	PLA2G4A_uc010pos.1_Missense_Mutation_p.F552I	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	612	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	TCCTTATGTGTTTGATCGGGA	0.418													23	77					0	0	0	0	A	186946794	A	A	186946794	3	1	140	1	0	0	0	0	1	0	0	0	12056	1725	60	5	1892	5	PLA2G4A	1	186946794	Missense_Mutation	SNP	T	TCGA-CR-7369-01A-11D-2129-08	32422150	186946794	62303827	10	25198											
ASPM	259266	broad.mit.edu	37	chr1	197091601	197091601	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ataccactgaaccagtttgcGtacattccacagtttgagta	12	12	7	10	1	0	2	0	2	0	0	1	2	1	2	3	0	4	4	3	0	4	6			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:197091601G>A	uc001gtu.2	-	14	3772	c.3515C>T	c.(3514-3516)ACG>ATG	p.T1172M	ASPM_uc001gtv.2_Missense_Mutation_p.T1172M|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1172	CH 2.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ACCAGTTTGCGTACATTCCAC	0.413													9	38					0	0	0	0	A	197091601	A	A	197091601	3	1	140	1	0	0	0	0	1	0	0	0	1058	1145	40	1	6978	1	ASPM	1	197091601	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	10144807	197091601	52159020	11	25199											
GREM2	64388	broad.mit.edu	37	chr1	240656691	240656691	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgtaaggcgaggggatggCgcccgccggccggttcttcc	4	8	16	13	5	1	0	0	0	1	0	2	2	2	1	4	6	0	2	4	6	1	4			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:240656691C>T	uc001hys.2	-	2	365	c.85G>A	c.(85-87)GCC>ACC	p.A29T		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	29					BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			GAGGGGATGGCGCCCGCCGGC	0.622													10	17					0	0	0	0	T	240656691	T	T	240656691	3	4	140	1	0	0	0	0	1	0	0	0	6801	768	27	1	425	1	GREM2	1	240656691	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	43565090	240656691	8593930	12	25200											
HNRNPU	3192	broad.mit.edu	37	chr1	245021401	245021401	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaaagtatactcttcaggtAttggaaaatatggcttttcc	12	15	8	6	0	2	1	1	1	1	0	3	2	3	2	1	3	1	3	1	3	7	8			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr1:245021401A>G	uc001iaz.1	-	7	1624	c.1406T>C	c.(1405-1407)ATA>ACA	p.I469T	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Missense_Mutation_p.I193T|HNRNPU_uc001iba.1_Missense_Mutation_p.I450T|HNRNPU_uc001ibb.1_Missense_Mutation_p.I157T	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	469					CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			CTCTTCAGGTATTGGAAAATA	0.438													13	49					0	0	0	0	G	245021401	G	G	245021401	3	3	140	1	0	0	0	0	1	0	0	0	7312	449	16	5	1103	5	HNRNPU	1	245021401	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08	4364710	245021401	4229220	13	25201											
BRE	9577	broad.mit.edu	37	chr2	28210901	28210901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatacccagaactgcctcccGattttatctttggagaagat	12	12	7	10	1	1	3	0	0	1	3	2	5	2	3	3	1	3	0	3	1	5	4			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr2:28210901G>A	uc002rlr.2	+	5	565	c.247G>A	c.(247-249)GAT>AAT	p.D83N	BRE_uc002rlp.1_Missense_Mutation_p.D83N|BRE_uc002rlq.2_Missense_Mutation_p.D83N|BRE_uc002rls.2_Missense_Mutation_p.D83N|BRE_uc002rlt.2_Missense_Mutation_p.D83N|BRE_uc002rlu.2_Missense_Mutation_p.D83N|BRE_uc002rlv.2_5'UTR	NM_199194	NP_954664	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A	83	UEV-like 1.				apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			lung(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					ACTGCCTCCCGATTTTATCTT	0.398													94	326					0	0	0	0	A	28210901	A	A	28210901	3	1	140	1	0	0	0	0	1	0	0	0	1514	1058	37	1	257	1	BRE	2	28210901	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08		28210901	214988472	14	25202											
RAB1A	5861	broad.mit.edu	37	chr2	65318142	65318142	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgtcacatcatacacaactAtgatgccatgggctcctctg	10	11	7	13	0	3	1	2	1	1	0	4	1	4	1	2	1	3	1	2	1	3	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr2:65318142A>G	uc002sdm.2	-	4	649	c.263T>C	c.(262-264)ATA>ACA	p.I88T	RAB1A_uc002sdn.2_Intron|RAB1A_uc010yqe.1_Intron|RAB1A_uc002sdo.2_Intron	NM_004161	NP_004152	P62820	RAB1A_HUMAN	RAB1A, member RAS oncogene family isoform 1	88					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	GTP binding|GTPase activity				0						ATACACAACTATGATGCCATG	0.398													4	26					0	0	0	0	G	65318142	G	G	65318142	3	3	140	1	0	0	0	0	1	0	0	0	12970	449	16	5	366	5	RAB1A	2	65318142	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08	37107241	65318142	177881231	15	25203											
ZNF638	27332	broad.mit.edu	37	chr2	71633384	71633384	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accatgtattcataagtaatAgaaacaaggtaacaagttcc	18	10	6	7	0	1	1	1	0	0	1	2	1	2	1	2	1	2	4	2	1	8	7			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr2:71633384A>G	uc002shx.2	+	19	3446	c.3127A>G	c.(3127-3129)AGA>GGA	p.R1043G	ZNF638_uc010yqw.1_Missense_Mutation_p.R622G|ZNF638_uc002shy.2_Missense_Mutation_p.R1043G|ZNF638_uc002shz.2_Missense_Mutation_p.R1043G|ZNF638_uc002sia.2_Missense_Mutation_p.R1043G|ZNF638_uc002sib.1_Missense_Mutation_p.R1043G|ZNF638_uc010fed.2_RNA|ZNF638_uc002sic.2_Missense_Mutation_p.R140G	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1043					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						CATAAGTAATAGAAACAAGGT	0.343													14	40					0	0	0	0	G	71633384	G	G	71633384	3	3	140	1	0	0	0	0	1	0	0	0	18122	412	15	5	3197	5	ZNF638	2	71633384	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08	6315242	71633384	171565989	16	25204											
REG3A	5068	broad.mit.edu	37	chr2	79385538	79385538	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggacacgaaggatccctcagCcccactgagcacagacacca	13	3	9	16	1	1	2	1	1	0	1	2	5	2	4	4	2	2	1	4	2	1	0			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr2:79385538C>G	uc002sod.1	-	3	502	c.247G>C	c.(247-249)GCT>CCT	p.A83P	REG3A_uc002soe.1_Missense_Mutation_p.A83P|REG3A_uc002sof.1_Missense_Mutation_p.A83P	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	83	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						GATCCCTCAGCCCCACTGAGC	0.572													12	67					0	0	0	0	G	79385538	G	G	79385538	3	3	140	1	0	0	0	0	1	0	0	0	13277	739	26	4	292	4	REG3A	2	79385538	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	7752154	79385538	163813835	17	25205											
FAHD2A	51011	broad.mit.edu	37	chr2	96072879	96072879	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatcgtggggccctatgatGaggtggtcctcccaccacag	7	8	12	14	1	0	2	0	2	0	0	3	2	2	2	5	4	0	0	5	4	1	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr2:96072879G>A	uc002sur.2	+	3	615	c.436G>A	c.(436-438)GAG>AAG	p.E146K	FAHD2A_uc002sus.2_Missense_Mutation_p.E146K	NM_016044	NP_057128	Q96GK7	FAH2A_HUMAN	fumarylacetoacetate hydrolase domain containing	146							hydrolase activity|metal ion binding			ovary(1)	1						GCCCTATGATGAGGTGGTCCT	0.562													18	88					0	0	0	0	A	96072879	A	A	96072879	3	1	140	1	0	0	0	0	1	0	0	0	5401	1291	45	2	442	2	FAHD2A	2	96072879	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	16687341	96072879	147126494	18	25206											
CSRNP3	80034	broad.mit.edu	37	chr2	166533063	166533063	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggactgtggctgtgactgccGagtgttctgtgatccagaca	7	11	14	9	1	1	3	0	2	1	1	2	5	2	4	2	2	1	2	2	2	0	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr2:166533063G>A	uc002udf.2	+	6	1026	c.650G>A	c.(649-651)CGA>CAA	p.R217Q	CSRNP3_uc002udg.2_Missense_Mutation_p.R217Q	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	217	Cys-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						TGTGACTGCCGAGTGTTCTGT	0.542													21	50					0	0	0	0	A	166533063	A	A	166533063	3	1	140	1	0	0	0	0	1	0	0	0	3982	1058	37	1	660	1	CSRNP3	2	166533063	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	70460184	166533063	76666310	19	25207											
DHX30	22907	broad.mit.edu	37	chr3	47889378	47889378	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgctgagacttccatcacaAtcaatgacatcgtgcatgtg	11	12	8	10	1	2	2	2	2	0	1	4	3	3	2	1	0	2	2	1	0	2	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr3:47889378A>G	uc003cru.2	+	14	2644	c.2218A>G	c.(2218-2220)ATC>GTC	p.I740V	DHX30_uc003crt.2_Missense_Mutation_p.I701V|MIR1226_hsa-mir-1226|MI0006313_5'Flank	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	740	Helicase C-terminal.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TTCCATCACAATCAATGACAT	0.547													23	39					0	0	0	0	G	47889378	G	G	47889378	3	3	140	1	0	0	0	0	1	0	0	0	4526	101	4	5	2275	5	DHX30	3	47889378	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08		47889378	150133052	20	25208											
ROBO1	6091	broad.mit.edu	37	chr3	78987994	78987994	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcagctttgcagttcaaagTtgcaggttctccttttgaga	8	16	9	8	0	3	1	2	1	1	1	4	2	3	1	1	1	3	6	1	1	1	7			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr3:78987994T>G	uc003dqe.2	-	4	464	c.256A>C	c.(256-258)ACT>CCT	p.T86P	ROBO1_uc003dqb.2_Missense_Mutation_p.T47P|ROBO1_uc003dqc.2_Missense_Mutation_p.T47P|ROBO1_uc003dqd.2_Missense_Mutation_p.T47P	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	86	Extracellular (Potential).|Ig-like C2-type 1.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CAGTTCAAAGTTGCAGGTTCT	0.507													21	55					0	0	0	0	G	78987994	G	G	78987994	3	3	140	1	0	0	0	0	1	0	0	0	13578	1725	60	5	4824	5	ROBO1	3	78987994	Missense_Mutation	SNP	T	TCGA-CR-7369-01A-11D-2129-08	31098616	78987994	119034436	21	25209											
ZPLD1	131368	broad.mit.edu	37	chr3	102171893	102171893	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcatggggactcccactgCagagggttcatcaataacaa	13	7	11	10	0	2	1	2	0	0	1	3	2	3	2	1	4	2	3	1	4	3	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr3:102171893C>A	uc003dvs.1	+	10	1119	c.237C>A	c.(235-237)TGC>TGA	p.C79*	ZPLD1_uc003dvt.1_Nonsense_Mutation_p.C95*|ZPLD1_uc011bhg.1_Nonsense_Mutation_p.C79*	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	79	ZP.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						ACTCCCACTGCAGAGGGTTCA	0.453													74	36					4.09166e-32	5.0793e-32	1	0	A	102171893	A	A	102171893	4	1	140	1	0	0	0	0	0	1	0	0	18288	718	25	4	295	4	ZPLD1	3	102171893	Nonsense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	23183899	102171893	95850537	22	25210											
WDR5B	54554	broad.mit.edu	37	chr3	122133906	122133906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acaaagtcttgagacactttCctgttttcacctcccatatt	10	15	4	12	0	2	1	1	1	1	1	4	2	4	1	3	0	0	1	3	0	2	6			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr3:122133906C>T	uc003efa.1	-	1	977	c.470G>A	c.(469-471)GGA>GAA	p.G157E		NM_019069	NP_061942	Q86VZ2	WDR5B_HUMAN	WD repeat domain 5B	157	WD 3.									ovary(3)	3				GBM - Glioblastoma multiforme(114;0.0704)		GAGACACTTTCCTGTTTTCAC	0.403													22	81					0	0	0	0	T	122133906	T	T	122133906	3	4	140	1	0	0	0	0	1	0	0	0	17377	855	30	2	526	2	WDR5B	3	122133906	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	19962013	122133906	75888524	23	25211											
TRIM59	286827	broad.mit.edu	37	chr3	160156068	160156069	+	Frame_Shift_Del	DEL	TG	-	-																															agaaattttcattttgggaaTgagaacgttcttaatttgtc																										TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr3:160156068_160156069delTG	uc003fdm.2	-	3	1098_1099	c.903_904delCA	c.(901-906)CTCATTfs	p.L301fs	IFT80_uc003fda.2_RNA	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	301_302						integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ATTTTGGGAATGAGAACGTTCT	0.342													---	---	---								-	160156069	-	-	160156068	7	5	140	1	0	1	0	1	0	0	0	0	16599	1464	51	0	311	0	TRIM59	3	160156068	Frame_Shift_Del	DEL	TG	TCGA-CR-7369-01A-11D-2129-08	38022162	160156068	37866362	24	25212											
AHSG	197	broad.mit.edu	37	chr3	186338468	186338468	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccgtcccctccacttggcGcacctggactccctccagct	4	9	7	21	2	0	0	0	0	0	0	5	1	5	1	7	2	1	2	7	2	0	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr3:186338468G>A	uc003fqk.3	+	7	934	c.853G>A	c.(853-855)GCA>ACA	p.A285T	AHSG_uc003fql.3_Missense_Mutation_p.A286T|AHSG_uc003fqm.3_Missense_Mutation_p.A284T|AHSG_uc010hyp.2_Missense_Mutation_p.A248T	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	285					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		TCCACTTGGCGCACCTGGACT	0.642													126	83					0	0	0	0	A	186338468	A	A	186338468	3	1	140	1	0	0	0	0	1	0	0	0	420	1087	38	1	879	1	AHSG	3	186338468	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	26182400	186338468	11683962	25	25213											
WHSC1	7468	broad.mit.edu	37	chr4	1902895	1902895	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagaaggaacaggaagaggAgcataaaatatgactccttg	17	6	12	6	1	0	3	0	1	0	2	1	7	1	6	1	3	2	1	1	3	6	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr4:1902895A>T	uc003gdz.3	+	2	690	c.514A>T	c.(514-516)AGC>TGC	p.S172C	WHSC1_uc003geb.3_Missense_Mutation_p.S172C|WHSC1_uc003gec.3_Missense_Mutation_p.S172C|WHSC1_uc003ged.3_Missense_Mutation_p.S172C|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdx.2_Missense_Mutation_p.S172C|WHSC1_uc003gdy.1_Missense_Mutation_p.S172C|WHSC1_uc010icd.1_Missense_Mutation_p.S172C|WHSC1_uc003gea.1_Missense_Mutation_p.S172C|WHSC1_uc010ice.1_Missense_Mutation_p.S172C|WHSC1_uc003geg.1_Missense_Mutation_p.S172C|WHSC1_uc003geh.1_Missense_Mutation_p.S172C	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	172					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CAGGAAGAGGAGCATAAAATA	0.438			T	IGH@	MM								12	22					0	0	0	0	T	1902895	T	T	1902895	3	4	140	1	0	0	0	0	1	0	0	0	17430	304	11	5	516	5	WHSC1	4	1902895	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08		1902895	189251381	26	25214											
SCARB2	950	broad.mit.edu	37	chr4	77091132	77091132	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgggaaagacataatgatgGgtgcacctgcatttgaagga	13	9	14	5	0	0	3	0	2	0	1	0	5	0	5	1	3	2	2	1	3	3	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr4:77091132G>T	uc003hju.1	-	8	1340	c.1001C>A	c.(1000-1002)CCC>CAC	p.P334H	SCARB2_uc011cbu.1_Missense_Mutation_p.P191H	NM_005506	NP_005497	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	334	Lumenal (Potential).				cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity				0			Lung(101;0.196)			CATAATGATGGGTGCACCTGC	0.413													5	107					4.096e-09	4.608e-09	1	0	T	77091132	T	T	77091132	3	4	140	1	0	0	0	0	1	0	0	0	13947	1232	43	4	455	4	SCARB2	4	77091132	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	75188237	77091132	114063144	27	25215											
SEC31A	22872	broad.mit.edu	37	chr4	83748771	83748771	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgatgggaacaggaggcatGaagttttcaggcatctgtta	11	11	14	5	0	2	2	1	2	1	0	2	4	2	4	0	4	1	4	0	4	3	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr4:83748771G>A	uc003hnf.2	-	24	3206	c.3042C>T	c.(3040-3042)TTC>TTT	p.F1014F	SEC31A_uc003hnd.2_Silent_p.F183F|SEC31A_uc003hne.2_Silent_p.F763F|SEC31A_uc011ccl.1_Silent_p.F960F|SEC31A_uc003hnl.2_Silent_p.F861F|SEC31A_uc003hng.2_Silent_p.F999F|SEC31A_uc003hnh.2_Silent_p.F1014F|SEC31A_uc003hni.2_Silent_p.F900F|SEC31A_uc003hnj.2_Silent_p.F975F|SEC31A_uc011ccm.1_Silent_p.F994F|SEC31A_uc011ccn.1_Silent_p.F999F|SEC31A_uc003hnk.2_Silent_p.F975F|SEC31A_uc003hnm.2_Silent_p.F1014F	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	1014	Interaction with PDCD6.|Pro-rich.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				CAGGAGGCATGAAGTTTTCAG	0.433													7	181					0	0	0	0	A	83748771	A	A	83748771	2	1	140	1	0	0	0	0	0	0	0	1	14063	1281	45	2		2	SEC31A	4	83748771	Silent	SNP	G	TCGA-CR-7369-01A-11D-2129-08	6657639	83748771	107405505	28	25216											
ADH6	130	broad.mit.edu	37	chr4	100131636	100131636	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acattctccacactgtggcaGaaagagtgtgataactttgt	12	12	9	8	0	1	3	0	1	1	2	2	3	1	3	1	1	1	1	1	1	2	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr4:100131636G>A	uc003hup.3	-	4	380	c.286C>T	c.(286-288)CTG>TTG	p.L96L	uc003hum.1_Intron|ADH6_uc003huo.2_Silent_p.L96L|ADH6_uc011cef.1_5'UTR|ADH6_uc010ile.2_Silent_p.L96L	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	96					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	CACTGTGGCAGAAAGAGTGTG	0.303													28	80					0	0	0	0	A	100131636	A	A	100131636	2	1	140	1	0	0	0	0	0	0	0	1	312	933	33	2		2	ADH6	4	100131636	Silent	SNP	G	TCGA-CR-7369-01A-11D-2129-08	16382865	100131636	91022640	29	25217											
LRBA	987	broad.mit.edu	37	chr4	151773953	151773953	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcgtatctggttgctgggatCctactgaaacattaatatcc	10	14	8	9	1	1	1	0	1	1	0	4	2	3	2	2	2	3	3	2	2	5	5			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr4:151773953C>A	uc010ipj.2	-	23	3383	c.2909G>T	c.(2908-2910)GGA>GTA	p.G970V	LRBA_uc003ilu.3_Missense_Mutation_p.G970V	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	970						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TTGCTGGGATCCTACTGAAAC	0.403													12	41					7.03913e-09	7.7574e-09	1	0	A	151773953	A	A	151773953	3	1	140	1	0	0	0	0	1	0	0	0	8981	855	30	2	5826	2	LRBA	4	151773953	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	51642317	151773953	39380323	30	25218											
RAPGEF2	9693	broad.mit.edu	37	chr4	160266481	160266481	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgagccagcaaccaacacaTgtgagtttttccttaaagtg	12	11	9	9	0	0	2	0	2	0	0	1	2	1	2	3	0	4	2	3	0	4	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr4:160266481T>G	uc003iqg.3	+	18	3329	c.3019T>G	c.(3019-3021)TTG>GTG	p.L1007V		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	1007					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		AACCAACACATGTGAGTTTTT	0.463													11	56					0	0	0	0	G	160266481	G	G	160266481	3	3	140	1	0	0	0	0	1	0	0	0	13109	1478	51	5	3089	5	RAPGEF2	4	160266481	Missense_Mutation	SNP	T	TCGA-CR-7369-01A-11D-2129-08	8492528	160266481	30887795	31	25219											
GLRA3	8001	broad.mit.edu	37	chr4	175598318	175598318	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	taccctggccggtgctgcatCcatgttgatccagaatgaaa	10	10	10	11	1	0	3	0	2	0	1	2	3	2	3	4	2	3	3	4	2	3	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr4:175598318C>T	uc003ity.1	-	7	1341	c.838G>A	c.(838-840)GAT>AAT	p.D280N	GLRA3_uc003itz.1_Missense_Mutation_p.D280N	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	280					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GGTGCTGCATCCATGTTGATC	0.473													20	38					0	0	0	0	T	175598318	T	T	175598318	3	4	140	1	0	0	0	0	1	0	0	0	6493	855	30	2	572	2	GLRA3	4	175598318	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	15331837	175598318	15555958	32	25220											
NIPBL	25836	broad.mit.edu	37	chr5	37008756	37008756	+	Nonsense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atatgaaaaacataggcagtTaattttggaagaaattttta	18	14	7	2	0	0	2	0	1	0	1	0	3	0	3	0	2	1	2	0	2	8	8			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr5:37008756T>G	uc003jkl.3	+	20	4851	c.4352T>G	c.(4351-4353)TTA>TGA	p.L1451*	NIPBL_uc003jkk.3_Nonsense_Mutation_p.L1451*	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1451					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CATAGGCAGTTAATTTTGGAA	0.279													24	116					0	0	0	0	G	37008756	G	G	37008756	4	3	140	1	0	0	0	0	0	1	0	0	10482	1764	61	5	4426	5	NIPBL	5	37008756	Nonsense_Mutation	SNP	T	TCGA-CR-7369-01A-11D-2129-08		37008756	143906504	33	25221											
HEATR7B2	133558	broad.mit.edu	37	chr5	41008749	41008749	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgttctccctgctgcatCacatgccgcctatggctcca	5	12	8	16	1	2	0	1	0	1	0	4	0	3	0	4	1	4	5	4	1	1	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr5:41008749C>T	uc003jmj.3	-	33	4057	c.3567G>A	c.(3565-3567)GTG>GTA	p.V1189V	HEATR7B2_uc003jmi.3_Silent_p.V744V	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1189	HEAT 13.						binding			ovary(6)|central_nervous_system(2)	8						CCTGCTGCATCACATGCCGCC	0.567													34	51					0	0	0	0	T	41008749	T	T	41008749	2	4	140	1	0	0	0	0	0	0	0	1	7074	813	29	2		2	HEATR7B2	5	41008749	Silent	SNP	C	TCGA-CR-7369-01A-11D-2129-08	3999993	41008749	139906511	34	25222											
YTHDC2	64848	broad.mit.edu	37	chr5	112868639	112868639	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgccgtatattttgtactCaaccaagacgattggcagct	10	12	8	11	2	1	1	1	0	0	1	1	2	1	1	3	1	4	4	3	1	5	6			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr5:112868639C>T	uc003kqn.2	+	5	922	c.739C>T	c.(739-741)CAA>TAA	p.Q247*	YTHDC2_uc010jce.1_Nonsense_Mutation_p.Q247*|YTHDC2_uc010jcf.1_5'UTR	NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	247	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		ATTTTGTACTCAACCAAGACG	0.378													4	74					0	0	0	0	T	112868639	T	T	112868639	4	4	140	1	0	0	0	0	0	1	0	0	17565	827	29	2	757	2	YTHDC2	5	112868639	Nonsense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	71859890	112868639	68046621	35	25223											
CEP120	153241	broad.mit.edu	37	chr5	122729184	122729184	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggaagtttcatggtacatGgaattaactaaacatttcag	14	13	8	6	0	2	0	2	0	0	0	2	2	2	2	0	3	3	2	0	3	6	5			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr5:122729184G>T	uc003ktk.2	-	7	702	c.620C>A	c.(619-621)CCA>CAA	p.P207Q	CEP120_uc011cwq.1_Missense_Mutation_p.P16Q|CEP120_uc010jcz.1_Missense_Mutation_p.P181Q	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	207						centrosome				ovary(1)	1						CATGGTACATGGAATTAACTA	0.303													20	31					3.6726e-16	4.40712e-16	1	0	T	122729184	T	T	122729184	3	4	140	1	0	0	0	0	1	0	0	0	3261	1348	47	4	2400	4	CEP120	5	122729184	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	9860545	122729184	58186076	36	25224											
DUSP22	56940	broad.mit.edu	37	chr6	348127	348127	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccggggtctccaggagcgtGacactggtgatcgcatacat	8	8	14	11	3	1	2	0	2	1	0	3	3	1	3	2	4	2	1	2	4	1	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr6:348127G>A	uc003msx.2	+	6	727	c.288G>A	c.(286-288)GTG>GTA	p.V96V	DUSP22_uc011dhn.1_Silent_p.V96V|DUSP22_uc003msy.1_Silent_p.V53V	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	96	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CCAGGAGCGTGACACTGGTGA	0.612													50	280					0	0	0	0	A	348127	A	A	348127	2	1	140	1	0	0	0	0	0	0	0	1	4843	1277	45	2		2	DUSP22	6	348127	Silent	SNP	G	TCGA-CR-7369-01A-11D-2129-08		348127	170766940	37	25225											
PPIL1	51645	broad.mit.edu	37	chr6	36824426	36824426	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatagatagatgcaccaccTcgacctgcccgattggaaga	12	7	9	13	2	0	3	0	0	0	3	1	6	0	4	5	1	2	1	5	1	3	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr6:36824426T>C	uc003omu.2	-	3	468	c.216A>G	c.(214-216)CGA>CGG	p.R72R		NM_016059	NP_057143	Q9Y3C6	PPIL1_HUMAN	peptidylprolyl isomerase-like 1	72	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						ATGCACCACCTCGACCTGCCC	0.458													12	45					0	0	0	0	C	36824426	C	C	36824426	2	2	140	1	0	0	0	0	0	0	0	1	12386	1538	54	5		5	PPIL1	6	36824426	Silent	SNP	T	TCGA-CR-7369-01A-11D-2129-08	36476299	36824426	134290641	38	25226											
LRFN2	57497	broad.mit.edu	37	chr6	40360344	40360344	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacacattgctcacggccgCtgccatcttgctgggggcct	5	10	12	14	2	2	0	1	0	1	0	2	0	2	0	3	3	4	4	3	3	1	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr6:40360344C>T	uc003oph.1	-	3	2173	c.1708G>A	c.(1708-1710)GCG>ACG	p.A570T		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	570	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTCACGGCCGCTGCCATCTTG	0.677													7	41					0	0	0	0	T	40360344	T	T	40360344	3	4	140	1	0	0	0	0	1	0	0	0	8988	797	28	4	665	4	LRFN2	6	40360344	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	3535918	40360344	130754723	39	25227											
CUL9	23113	broad.mit.edu	37	chr6	43189000	43189000	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaagcacctggccaagctCatctccaagcgctgtcccag	10	6	9	16	1	2	0	1	0	1	0	4	0	3	0	4	1	4	4	4	1	3	0			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr6:43189000C>T	uc003ouk.2	+	34	6768	c.6693C>T	c.(6691-6693)CTC>CTT	p.L2231L	CUL9_uc003oul.2_Silent_p.L2203L|CUL9_uc010jyk.2_Silent_p.L1383L|CUL9_uc003oun.2_Silent_p.L26L	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	2231					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						TGGCCAAGCTCATCTCCAAGC	0.612													12	39					0	0	0	0	T	43189000	T	T	43189000	2	4	140	1	0	0	0	0	0	0	0	1	4078	813	29	2		2	CUL9	6	43189000	Silent	SNP	C	TCGA-CR-7369-01A-11D-2129-08	2828656	43189000	127926067	40	25228											
BEND6	221336	broad.mit.edu	37	chr6	56857219	56857219	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctttctgcctggtgaaagctCcagtgaggatgaagagcctt	9	11	12	9	0	1	4	0	3	1	1	2	5	2	5	3	2	3	1	3	2	2	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr6:56857219C>T	uc010kab.2	+	3	750	c.164C>T	c.(163-165)TCC>TTC	p.S55F	BEND6_uc003pdg.2_RNA	NM_152731	NP_689944	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	55											0						GGTGAAAGCTCCAGTGAGGAT	0.403													55	209					0	0	0	0	T	56857219	T	T	56857219	3	4	140	1	0	0	0	0	1	0	0	0	1404	855	30	2	170	2	BEND6	6	56857219	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	13668219	56857219	114257848	41	25229											
FNDC1	84624	broad.mit.edu	37	chr6	159653481	159653481	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgacaacgacttggtggActcagacgaagatgagcgcg	13	6	14	8	4	1	4	1	2	0	2	1	8	1	5	0	2	2	0	0	2	3	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr6:159653481A>G	uc010kjv.2	+	11	2137	c.1937A>G	c.(1936-1938)GAC>GGC	p.D646G	FNDC1_uc010kjw.1_Missense_Mutation_p.D531G	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	646						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GACTTGGTGGACTCAGACGAA	0.697													9	50					0	0	0	0	G	159653481	G	G	159653481	3	3	140	1	0	0	0	0	1	0	0	0	6000	275	10	5	1979	5	FNDC1	6	159653481	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08	102796262	159653481	11461586	42	25230											
PRPS1L1	221823	broad.mit.edu	37	chr7	18067095	18067095	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttggcagagattggggacCggctcttatccttcttatcc	6	13	11	11	1	2	1	0	0	2	1	4	3	4	2	3	4	0	3	3	4	2	5			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr7:18067095C>A	uc003stz.2	-	1	392	c.311G>T	c.(310-312)CGG>CTG	p.R104L		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	104					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					GATTGGGGACCGGCTCTTATC	0.468													36	110					6.90743e-12	8.02153e-12	1	0	A	18067095	A	A	18067095	3	1	140	1	0	0	0	0	1	0	0	0	12641	652	23	3	649	3	PRPS1L1	7	18067095	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08		18067095	141071568	43	25231											
LAMB4	22798	broad.mit.edu	37	chr7	107732207	107732207	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcggcattcacactgcccaTtcttgggtgagcacctgagg	7	9	13	12	1	2	2	1	2	1	0	2	2	2	2	2	4	2	2	2	4	0	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr7:107732207T>C	uc010ljo.1	-	14	1649	c.1565A>G	c.(1564-1566)AAT>AGT	p.N522S	LAMB4_uc003vey.2_Missense_Mutation_p.N522S	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	522	Laminin EGF-like 5; truncated.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						ACACTGCCCATTCTTGGGTGA	0.502													18	69					0	0	0	0	C	107732207	C	C	107732207	3	2	140	1	0	0	0	0	1	0	0	0	8653	1493	52	5	3804	5	LAMB4	7	107732207	Missense_Mutation	SNP	T	TCGA-CR-7369-01A-11D-2129-08	89665112	107732207	51406456	44	25232											
CPA5	93979	broad.mit.edu	37	chr7	130002807	130002807	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catagagctcgtcacaaaccCtgatgggtttgcttttaccc	9	12	8	12	1	1	2	1	1	0	1	2	2	1	2	2	1	4	3	2	1	3	4			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr7:130002807C>T	uc010lmd.1	+	10	1339	c.719C>T	c.(718-720)CCT>CTT	p.P240L	CPA5_uc003vps.2_Missense_Mutation_p.P240L|CPA5_uc003vpt.2_Missense_Mutation_p.P240L|CPA5_uc010lme.1_Missense_Mutation_p.P240L|CPA5_uc003vpu.1_Missense_Mutation_p.P240L	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1	240					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)					GTCACAAACCCTGATGGGTTT	0.502													3	41					0	0	0	0	T	130002807	T	T	130002807	3	4	140	1	0	0	0	0	1	0	0	0	3808	681	24	4	745	4	CPA5	7	130002807	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	22270600	130002807	29135856	45	25233											
PXDNL	137902	broad.mit.edu	37	chr8	52336282	52336282	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttaccactctcagtaatctGcacaccttcctagggagcaa	11	11	6	13	0	2	0	1	0	2	0	4	1	3	1	3	1	3	3	3	1	4	5			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr8:52336282G>T	uc003xqu.3	-	14	1749	c.1648C>A	c.(1648-1650)CAG>AAG	p.Q550K		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	550	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TCAGTAATCTGCACACCTTCC	0.403													12	43					7.03913e-09	7.7574e-09	1	0	T	52336282	T	T	52336282	3	4	140	1	0	0	0	0	1	0	0	0	12913	1328	46	4	2783	4	PXDNL	8	52336282	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08		52336282	94027740	46	25234											
ST18	9705	broad.mit.edu	37	chr8	53044649	53044649	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggattctccttctgtctCttggcagccagaggacagcc	8	10	11	12	0	3	2	0	0	3	2	5	4	3	4	3	3	2	1	3	3	0	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr8:53044649C>G	uc003xqz.2	-	17	2691	c.2535G>C	c.(2533-2535)AAG>AAC	p.K845N	ST18_uc011ldq.1_Missense_Mutation_p.K492N|ST18_uc011ldr.1_Missense_Mutation_p.K810N|ST18_uc011lds.1_Missense_Mutation_p.K750N|ST18_uc003xra.2_Missense_Mutation_p.K845N	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	845						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCTTCTGTCTCTTGGCAGCCA	0.522													14	60					0	0	0	0	G	53044649	G	G	53044649	3	3	140	1	0	0	0	0	1	0	0	0	15278	912	32	2	628	2	ST18	8	53044649	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	708367	53044649	93319373	47	25235											
DCAF4L2	138009	broad.mit.edu	37	chr8	88886149	88886149	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagtcccactctgactgtCtttttctgcttgtctgcttc	3	19	7	12	0	4	2	0	2	4	0	6	2	5	2	1	0	2	2	1	0	0	5			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr8:88886149C>A	uc003ydz.2	-	1	148	c.51G>T	c.(49-51)AAG>AAT	p.K17N		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	17										ovary(1)	1						CTCTGACTGTCTTTTTCTGCT	0.537													18	52					3.5997e-14	4.22573e-14	1	0	A	88886149	A	A	88886149	3	1	140	1	0	0	0	0	1	0	0	0	4289	912	32	2	1140	2	DCAF4L2	8	88886149	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	35841500	88886149	57477873	48	25236											
UBR5	51366	broad.mit.edu	37	chr8	103354705	103354705	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattttttccaaataccttaTcaggccaccactgcaaatct	13	13	3	12	0	2	0	1	0	1	0	3	0	3	0	4	1	2	1	4	1	5	5			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr8:103354705T>C	uc003ykr.1	-	9	1127	c.1094A>G	c.(1093-1095)GAT>GGT	p.D365G	UBR5_uc003yks.1_Missense_Mutation_p.D365G	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	365					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AAATACCTTATCAGGCCACCA	0.408													81	88					0	0	0	0	C	103354705	C	C	103354705	3	2	140	1	0	0	0	0	1	0	0	0	16973	1435	50	5	7509	5	UBR5	8	103354705	Missense_Mutation	SNP	T	TCGA-CR-7369-01A-11D-2129-08	14468556	103354705	43009317	49	25237											
PLEC	5339	broad.mit.edu	37	chr8	145008578	145008579	+	Frame_Shift_Ins	INS	-	G	G																															catccagcgggtggtagccaINSgggggcaccttgagctggcc																										TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr8:145008578_145008579insG	uc003zaf.1	-	11	1657_1658	c.1487_1488insC	c.(1486-1488)CCTfs	p.P496fs	PLEC_uc003zab.1_Frame_Shift_Ins_p.P359fs|PLEC_uc003zac.1_Frame_Shift_Ins_p.P363fs|PLEC_uc003zad.2_Frame_Shift_Ins_p.P359fs|PLEC_uc003zae.1_Frame_Shift_Ins_p.P327fs|PLEC_uc003zag.1_Frame_Shift_Ins_p.P337fs|PLEC_uc003zah.2_Frame_Shift_Ins_p.P345fs|PLEC_uc003zaj.2_Frame_Shift_Ins_p.P386fs	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	496	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GGTGGTAGCCAGGGGGCACCTT	0.673													---	---	---								G	145008579	G	G	145008578	7	5	140	1	0	1	1	0	0	0	0	0	12107	175	7	0	12654	0	PLEC	8	145008578	Frame_Shift_Ins	INS	-	TCGA-CR-7369-01A-11D-2129-08	41653873	145008578	1355444	50	25238											
GPR172A	79581	broad.mit.edu	37	chr8	145583549	145583549	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcctcgaatgtcactttcCtgcccttcttgagccacctg	5	13	8	15	1	2	1	1	1	1	0	4	2	3	1	5	0	3	0	5	0	1	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr8:145583549C>T	uc003zcc.1	+	3	554	c.397C>T	c.(397-399)CTG>TTG	p.L133L	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Silent_p.L133L|GPR172A_uc003zce.1_Silent_p.L133L|GPR172A_uc010mfy.1_Silent_p.L133L|GPR172A_uc003zcf.1_Silent_p.L133L|GPR172A_uc011llc.1_Silent_p.L45L	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	133						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			TGTCACTTTCCTGCCCTTCTT	0.602													65	281					0	0	0	0	T	145583549	T	T	145583549	2	4	140	1	0	0	0	0	0	0	0	1	6707	680	24	4		4	GPR172A	8	145583549	Silent	SNP	C	TCGA-CR-7369-01A-11D-2129-08	574971	145583549	780473	51	25239											
GLIS3	169792	broad.mit.edu	37	chr9	4117907	4117907	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgcgctggtcgatgtggAccttctcgatgtgccgcacg	4	12	13	12	5	1	0	0	0	1	0	3	3	1	1	2	2	2	2	2	2	0	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr9:4117907A>G	uc003zhw.1	-	3	1300	c.1106T>C	c.(1105-1107)GTC>GCC	p.V369A	GLIS3_uc003zhx.1_Missense_Mutation_p.V524A|GLIS3_uc003zic.1_Missense_Mutation_p.V524A|GLIS3_uc003zie.1_Missense_Mutation_p.V524A|GLIS3_uc010mhh.1_Missense_Mutation_p.V399A|GLIS3_uc003zid.1_Missense_Mutation_p.V302A|GLIS3_uc010mhi.1_Missense_Mutation_p.V331A|GLIS3_uc003zif.1_Missense_Mutation_p.V302A|GLIS3_uc003zig.1_Missense_Mutation_p.V368A|GLIS3_uc003zih.1_Missense_Mutation_p.V302A|GLIS3_uc003zhy.1_Missense_Mutation_p.V302A|GLIS3_uc003zhz.1_Missense_Mutation_p.V302A|GLIS3_uc003zib.1_Missense_Mutation_p.V368A|GLIS3_uc010mhg.1_Missense_Mutation_p.V302A	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	369	C2H2-type 1.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GTCGATGTGGACCTTCTCGAT	0.612													11	73					0	0	0	0	G	4117907	G	G	4117907	3	3	140	1	0	0	0	0	1	0	0	0	6484	275	10	5	1253	5	GLIS3	9	4117907	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08		4117907	137095524	52	25240											
PLIN2	123	broad.mit.edu	37	chr9	19126190	19126190	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggtcttcacaccgttctctgCcatctcacacacagacttca	9	11	5	16	1	5	1	3	0	3	1	7	1	5	1	2	1	1	1	2	1	0	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr9:19126190C>A	uc003zno.2	-	3	327	c.148G>T	c.(148-150)GCA>TCA	p.A50S	PLIN2_uc011lna.1_Missense_Mutation_p.A22S|PLIN2_uc011lnb.1_Missense_Mutation_p.A50S	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	50					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						CCGTTCTCTGCCATCTCACAC	0.517													39	82					1.59361e-14	1.89132e-14	1	0	A	19126190	A	A	19126190	3	1	140	1	0	0	0	0	1	0	0	0	12145	739	26	4	1189	4	PLIN2	9	19126190	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	15008283	19126190	122087241	53	25241											
PTEN	5728	broad.mit.edu	37	chr10	89692794	89692794	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatatccttttgaagaccAtaacccaccacagctagaac	16	8	4	13	0	0	3	0	1	0	2	1	3	1	3	4	0	3	1	4	0	6	5	rs121909238		TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr10:89692794A>G	uc001kfb.2	+	6	1309	c.278A>G	c.(277-279)CAT>CGT	p.H93R		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	93	Phosphatase tensin-type.		H -> R (in MCEPHAS).|H -> Y (in CD).	H->A: 75% reduction in phosphatase activity towards PtdIns(3,4,5)P3. Modest reduction in phosphatase activity towards PtdIns(3,4)P2.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.H93Y(3)|p.H93Q(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.H93fs*5(1)|p.H93D(1)|p.H93R(1)|p.Q87_P96del(1)|p.N82_P95del(1)|p.F90_P95>L(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TTTGAAGACCATAACCCACCA	0.338		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			21	63					0	0	0	0	G	89692794	G	G	89692794	3	3	140	1	0	0	0	0	1	0	0	0	12800	217	8	5	296	5	PTEN	10	89692794	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08		89692794	45841953	54	25242											
TLL2	7093	broad.mit.edu	37	chr10	98155039	98155039	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctcgatttcacatcctccGgcttctcatagccacaaaag	11	10	6	14	2	2	0	2	0	1	0	6	1	4	0	3	1	2	2	3	1	3	3	rs140011074		TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr10:98155039G>A	uc001kml.1	-	13	1857	c.1631C>T	c.(1630-1632)CCG>CTG	p.P544L	TLL2_uc009xvf.1_Missense_Mutation_p.P522L	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	544	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CACATCCTCCGGCTTCTCATA	0.507													4	87					0	0	0	0	A	98155039	A	A	98155039	3	1	140	1	0	0	0	0	1	0	0	0	16012	1116	39	1	1452	1	TLL2	10	98155039	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	8462245	98155039	37379708	55	25243											
TH	7054	broad.mit.edu	37	chr11	2190937	2190937	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtggccctcggggagaaGagcaggtttagcacggcctt	7	9	16	9	2	0	2	0	0	0	2	1	3	0	2	2	6	2	3	2	6	2	4			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr11:2190937G>A	uc001lvq.2	-	3	367	c.348C>T	c.(346-348)CTC>CTT	p.L116L	TH_uc001lvp.2_Silent_p.L112L|TH_uc001lvr.2_Silent_p.L85L|TH_uc010qxj.1_Silent_p.L89L|TH_uc001lvs.2_Silent_p.L85L|TH_uc001lvt.2_Silent_p.L89L|TH_uc009ydh.1_5'Flank	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	116					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	TCGGGGAGAAGAGCAGGTTTA	0.672													30	71					0	0	0	0	A	2190937	A	A	2190937	2	1	140	1	0	0	0	0	0	0	0	1	15904	929	33	2		2	TH	11	2190937	Silent	SNP	G	TCGA-CR-7369-01A-11D-2129-08		2190937	132815579	56	25244											
OR52B2	255725	broad.mit.edu	37	chr11	6191145	6191145	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccccacaacaggccatgttaGcactgttgtatatctcagtg	10	11	8	12	0	1	0	1	0	1	0	2	0	1	0	3	1	2	4	3	1	4	4			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr11:6191145G>A	uc010qzy.1	-	1	412	c.412C>T	c.(412-414)CTA>TTA	p.L138L		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCATGTTAGCACTGTTGTA	0.512													9	49					0	0	0	0	A	6191145	A	A	6191145	2	1	140	1	0	0	0	0	0	0	0	1	11165	962	34	4		4	OR52B2	11	6191145	Silent	SNP	G	TCGA-CR-7369-01A-11D-2129-08	4000208	6191145	128815371	57	25245											
ABCC8	6833	broad.mit.edu	37	chr11	17428479	17428479	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggggtcagggtcagggCgctgtcggtccacttggcca	5	8	17	11	2	2	0	2	0	0	0	4	0	3	0	2	6	1	2	2	6	0	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr11:17428479C>T	uc001mnc.2	-	25	3244	c.3118G>A	c.(3118-3120)GCC>ACC	p.A1040T		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1040	ABC transmembrane type-1 2.|Extracellular (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGGGTCAGGGCGCTGTCGGTC	0.652													6	87					0	0	0	0	T	17428479	T	T	17428479	3	4	140	1	0	0	0	0	1	0	0	0	58	768	27	1	1687	1	ABCC8	11	17428479	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	11237334	17428479	117578037	58	25246											
SLC5A12	159963	broad.mit.edu	37	chr11	26734241	26734241	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgaactggtttgttgaatcGtagttgtaagtactaaagga	12	13	12	4	2	0	1	0	1	0	0	1	3	0	2	0	2	2	6	0	2	7	7			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr11:26734241G>A	uc001mra.2	-	2	665	c.352C>T	c.(352-354)CGA>TGA	p.R118*	SLC5A12_uc001mrb.2_RNA|SLC5A12_uc001mrc.3_Nonsense_Mutation_p.R118*	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	118	Cytoplasmic (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						TTGTTGAATCGTAGTTGTAAG	0.418													60	189					0	0	0	0	A	26734241	A	A	26734241	4	1	140	1	0	0	0	0	0	1	0	0	14728	1153	40	1	1560	1	SLC5A12	11	26734241	Nonsense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	9305762	26734241	108272275	59	25247											
TTC17	55761	broad.mit.edu	37	chr11	43418289	43418289	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgtgggtactgtataacatgGcttcattttactggagaatt	10	15	10	6	1	1	1	1	0	0	1	1	2	1	1	0	3	3	3	0	3	5	7			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr11:43418289G>T	uc001mxi.2	+	6	708	c.694G>T	c.(694-696)GCT>TCT	p.A232S	TTC17_uc001mxh.2_Missense_Mutation_p.A232S|TTC17_uc010rfj.1_Missense_Mutation_p.A175S|TTC17_uc001mxj.2_Missense_Mutation_p.A2S	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	232							binding			ovary(5)	5						GTATAACATGGCTTCATTTTA	0.388													15	66					0.000308642	0.00031746	1	0	T	43418289	T	T	43418289	3	4	140	1	0	0	0	0	1	0	0	0	16752	1203	42	4	716	4	TTC17	11	43418289	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	16684048	43418289	91588227	60	25248											
FAT3	120114	broad.mit.edu	37	chr11	92613978	92613978	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcttcccaaacccctgccGgaatggaggatcctgcgatc	8	8	10	15	2	0	0	0	0	0	0	3	4	2	3	5	3	4	1	5	3	2	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr11:92613978G>A	uc001pdj.3	+	22	12226	c.12209G>A	c.(12208-12210)CGG>CAG	p.R4070Q	FAT3_uc001pdi.3_Missense_Mutation_p.R510Q	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4070	EGF-like 3.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AACCCCTGCCGGAATGGAGGA	0.478										TCGA Ovarian(4;0.039)			6	179					0	0	0	0	A	92613978	A	A	92613978	3	1	140	1	0	0	0	0	1	0	0	0	5723	1116	39	1	12295	1	FAT3	11	92613978	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	49195689	92613978	42392538	61	25249											
OR8D2	283160	broad.mit.edu	37	chr11	124189328	124189328	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggcttgaaatacatgaatgTtatagacccaaaaaagatgc	17	9	9	6	0	0	4	0	2	0	2	0	4	0	4	1	1	2	2	1	1	8	4			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr11:124189328T>A	uc010sah.1	-	1	766	c.766A>T	c.(766-768)ACA>TCA	p.T256S		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TACATGAATGTTATAGACCCA	0.438													37	81					0	0	0	0	A	124189328	A	A	124189328	3	1	140	1	0	0	0	0	1	0	0	0	11286	1725	60	5	172	5	OR8D2	11	124189328	Missense_Mutation	SNP	T	TCGA-CR-7369-01A-11D-2129-08	31575350	124189328	10817188	62	25250											
AVPR1A	552	broad.mit.edu	37	chr12	63544069	63544069	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagacgaagtactgcggcGtgctcagcacgaagctcagc	12	5	13	11	4	2	2	2	0	0	2	2	4	2	2	0	1	6	4	0	1	4	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr12:63544069G>A	uc001sro.1	-	1	2522	c.548C>T	c.(547-549)ACG>ATG	p.T183M		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	183	Helical; Name=4; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	GTACTGCGGCGTGCTCAGCAC	0.642													29	50					0	0	0	0	A	63544069	A	A	63544069	3	1	140	1	0	0	0	0	1	0	0	0	1233	1145	40	1	716	1	AVPR1A	12	63544069	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08		63544069	70307826	63	25251											
KDM2B	84678	broad.mit.edu	37	chr12	122018774	122018774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgctgcatgtctttttcgtgGggggtgatcctctgcagatc	4	15	13	9	1	2	2	0	1	2	1	5	2	3	2	1	3	3	3	1	3	0	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr12:122018774G>A	uc001uat.2	-	1	147	c.43C>T	c.(43-45)CCA>TCA	p.P15S	KDM2B_uc001uas.2_5'Flank|KDM2B_uc001uau.2_5'UTR|KDM2B_uc001uav.3_Missense_Mutation_p.P15S	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	15					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CTTTTTCGTGGGGGGTGATCC	0.483													32	135					0	0	0	0	A	122018774	A	A	122018774	3	1	140	1	0	0	0	0	1	0	0	0	8164	1232	43	4	4148	4	KDM2B	12	122018774	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	58474705	122018774	11833121	64	25252											
TPP2	7174	broad.mit.edu	37	chr13	103295686	103295686	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attctataagttttgttctcTtccagagaaaggaacactga	13	14	7	7	0	2	2	0	1	2	1	4	4	3	3	1	1	1	2	1	1	4	7			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr13:103295686T>C	uc001vpi.3	+	17	2238	c.2135T>C	c.(2134-2136)CTT>CCT	p.L712P		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	712					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTTTGTTCTCTTCCAGAGAAA	0.373													12	32					0	0	0	0	C	103295686	C	C	103295686	3	2	140	1	0	0	0	0	1	0	0	0	16479	1609	56	5	2201	5	TPP2	13	103295686	Missense_Mutation	SNP	T	TCGA-CR-7369-01A-11D-2129-08		103295686	11874192	65	25253											
POTEG	404785	broad.mit.edu	37	chr14	19553545	19553545	+	Frame_Shift_Del	DEL	G	-	-																															gggagcggcaagagcaacgtGggcacttctggagaccacga																										TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr14:19553545delG	uc001vuz.1	+	1	181	c.129delG	c.(127-129)GTGfs	p.V43fs	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	43										ovary(1)	1						AGAGCAACGTGGGCACTTCTG	0.602													---	---	---								-	19553545	-	-	19553545	7	5	140	1	0	1	0	1	0	0	0	0	12321	1335	47	0	131	0	POTEG	14	19553545	Frame_Shift_Del	DEL	G	TCGA-CR-7369-01A-11D-2129-08		19553545	87795995	66	25254											
LRFN5	145581	broad.mit.edu	37	chr14	42360816	42360816	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaatacaaggctgtagtgtAacgctgccccagtccgtgtc	10	9	10	12	2	0	0	0	0	0	0	2	0	1	0	3	1	3	4	3	1	5	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr14:42360816A>T	uc001wvm.2	+	4	2947	c.1749A>T	c.(1747-1749)GTA>GTT	p.V583V	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	583	Cytoplasmic (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GCTGTAGTGTAACGCTGCCCC	0.453										HNSCC(30;0.082)			22	48					0	0	0	0	T	42360816	T	T	42360816	2	4	140	1	0	0	0	0	0	0	0	1	8991	349	13	5		5	LRFN5	14	42360816	Silent	SNP	A	TCGA-CR-7369-01A-11D-2129-08	22807271	42360816	64988724	67	25255											
PCNX	22990	broad.mit.edu	37	chr14	71500712	71500712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccagaagaccctctatctGaagtaaaagatccactgcct	14	9	6	12	0	2	4	0	1	2	3	4	4	4	4	4	0	1	1	4	0	5	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr14:71500712G>A	uc001xmo.2	+	18	4179	c.3733G>A	c.(3733-3735)GAA>AAA	p.E1245K	PCNX_uc010are.1_Missense_Mutation_p.E1134K|PCNX_uc010arf.1_Missense_Mutation_p.E105K	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1245						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CCCTCTATCTGAAGTAAAAGA	0.308													35	87					0	0	0	0	A	71500712	A	A	71500712	3	1	140	1	0	0	0	0	1	0	0	0	11645	1291	45	2	3803	2	PCNX	14	71500712	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	29139896	71500712	35848828	68	25256											
C15orf42	90381	broad.mit.edu	37	chr15	90168261	90168261	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttctggccttcccaaacttCgaattaagaagatagacccc	12	10	6	13	1	1	3	0	0	1	3	3	4	2	3	4	1	1	0	4	1	5	5			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr15:90168261C>T	uc002boe.2	+	20	4720	c.4720C>T	c.(4720-4722)CGA>TGA	p.R1574*	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1574					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TCCCAAACTTCGAATTAAGAA	0.537													32	98					0	0	0	0	T	90168261	T	T	90168261	4	4	140	1	0	0	0	0	0	1	0	0	1802	876	31	1	4798	1	C15orf42	15	90168261	Nonsense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08		90168261	12363131	69	25257											
RBBP6	5930	broad.mit.edu	37	chr16	24551988	24551988	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attttcctctaaactcaactAtgataccgtcacctttgatg	11	15	4	11	1	3	2	2	2	1	0	4	2	4	2	3	0	3	0	3	0	5	6			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr16:24551988A>G	uc002dmh.2	+	1	1081	c.41A>G	c.(40-42)TAT>TGT	p.Y14C	RBBP6_uc010vcb.1_Intron|RBBP6_uc002dmg.2_Missense_Mutation_p.Y14C|RBBP6_uc002dmi.2_Missense_Mutation_p.Y14C|RBBP6_uc010bxr.2_Missense_Mutation_p.Y14C	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	14	DWNN.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		AAACTCAACTATGATACCGTC	0.473													20	72					0	0	0	0	G	24551988	G	G	24551988	3	3	140	1	0	0	0	0	1	0	0	0	13168	449	16	5	43	5	RBBP6	16	24551988	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08		24551988	65802765	70	25258											
RGS9	8787	broad.mit.edu	37	chr17	63223491	63223491	+	Frame_Shift_Del	DEL	A	-	-																															gtcgggtgaccgggccacagAaaaggaggtcatctgcccct																										TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr17:63223491delA	uc002jfe.2	+	19	2101	c.1991delA	c.(1990-1992)GAAfs	p.E664fs	RGS9_uc002jfd.2_Frame_Shift_Del_p.E661fs|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Frame_Shift_Del_p.E435fs	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	664					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						CGGGCCACAGAAAAGGAGGTC	0.582													---	---	---								-	63223491	-	-	63223491	7	5	140	1	0	1	0	1	0	0	0	0	13378	246	9	0	2120	0	RGS9	17	63223491	Frame_Shift_Del	DEL	A	TCGA-CR-7369-01A-11D-2129-08		63223491	17971719	71	25259											
CCDC40	55036	broad.mit.edu	37	chr17	78063685	78063685	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagatccacaggatgaaggTgaggggaggagagcggcgtg	11	4	20	6	3	0	4	0	2	0	2	1	8	1	6	1	6	1	0	1	6	1	0			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr17:78063685T>G	uc010dht.2	+	17	2859	c.2832_splice	c.e17+2	p.K944_splice	CCDC40_uc002jxm.3_Splice_Site_p.K727_splice|CCDC40_uc002jxn.3_Splice_Site_p.K340_splice	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40						axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGGATGAAGGTGAGGGGAGGA	0.627													10	32					0	0	0	0	G	78063685	G	G	78063685	5	3	140	1	0	0	0	0	0	0	1	0	2825	1710	59	5	2900	5	CCDC40	17	78063685	Splice_Site	SNP	T	TCGA-CR-7369-01A-11D-2129-08	14840194	78063685	3131525	72	25260											
FAM38B	63895	broad.mit.edu	37	chr18	10691302	10691302	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgcgttgggtagccacaacGgatctggtaagcagacaacc	11	7	12	11	3	1	1	0	0	1	1	2	2	1	2	2	3	4	4	2	3	4	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr18:10691302G>A	uc002kor.3	-	6	942	c.802C>T	c.(802-804)CGT>TGT	p.R268C	FAM38B_uc002koq.2_Missense_Mutation_p.R166C	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2311						integral to membrane	ion channel activity			ovary(1)	1						TAGCCACAACGGATCTGGTAA	0.468													28	69					0	0	0	0	A	10691302	A	A	10691302	3	1	140	1	0	0	0	0	1	0	0	0	5587	1116	39	1	1363	1	FAM38B	18	10691302	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08		10691302	67385946	73	25261											
PIP5K1C	23396	broad.mit.edu	37	chr19	3648623	3648623	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagacccgggcacccacCtgtaggactgcaggatgtcg	8	6	13	14	2	0	1	0	0	0	1	1	3	0	3	3	3	2	4	3	3	1	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr19:3648623C>A	uc002lyj.1	-	9	1268	c.1211G>T	c.(1210-1212)AGG>ATG	p.R404M	PIP5K1C_uc010xhq.1_Missense_Mutation_p.R404M|PIP5K1C_uc010xhr.1_Missense_Mutation_p.R404M	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	404	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		GGGCACCCACCTGTAGGACTG	0.706													15	57					5.3912e-06	5.76485e-06	1	0	A	3648623	A	A	3648623	3	1	140	1	0	0	0	0	1	0	0	0	11996	695	24	4	835	4	PIP5K1C	19	3648623	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08		3648623	55480360	74	25262											
CCDC94	55702	broad.mit.edu	37	chr19	4267629	4267629	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcacctgcaggccccaaaGcccaagaggaaggtggaggt	12	4	13	12	0	1	1	1	0	0	1	1	3	1	3	4	5	2	1	4	5	3	0	rs144896215	byFrequency	TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr19:4267629G>A	uc002lzv.3	+	7	750	c.717G>A	c.(715-717)AAG>AAA	p.K239K		NM_018074	NP_060544	Q9BW85	CCD94_HUMAN	coiled-coil domain containing 94	239											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)		AGGCCCCAAAGCCCAAGAGGA	0.687											OREG0025164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	37					0	0	0	0	A	4267629	A	A	4267629	2	1	140	1	0	0	0	0	0	0	0	1	2886	962	34	4		4	CCDC94	19	4267629	Silent	SNP	G	TCGA-CR-7369-01A-11D-2129-08	619006	4267629	54861354	75	25263											
ZNRF4	148066	broad.mit.edu	37	chr19	5455922	5455922	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggaggtcaagccagccaaCgcgtgccatcccatcgaggc	10	5	12	14	3	1	0	1	0	0	0	3	2	2	1	4	3	4	0	4	3	2	0			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr19:5455922C>T	uc002mca.3	+	1	497	c.420C>T	c.(418-420)AAC>AAT	p.N140N		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	140	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		AGCCAGCCAACGCGTGCCATC	0.672													22	67					0	0	0	0	T	5455922	T	T	5455922	2	4	140	1	0	0	0	0	0	0	0	1	18281	535	19	1		1	ZNRF4	19	5455922	Silent	SNP	C	TCGA-CR-7369-01A-11D-2129-08	1188293	5455922	53673061	76	25264											
MUC16	94025	broad.mit.edu	37	chr19	8966769	8966769	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctccgagccagtggcgagAagttacacagggagtccacc	10	6	12	13	2	1	1	0	0	1	1	3	4	2	2	4	2	2	1	4	2	2	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr19:8966769A>G	uc002mkp.2	-	81	43388	c.43184T>C	c.(43183-43185)TTC>TCC	p.F14395S	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.F1195S|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGTGGCGAGAAGTTACACAG	0.527													2	7					0	0	0	0	G	8966769	G	G	8966769	3	3	140	1	0	0	0	0	1	0	0	0	10026	246	9	5	355	5	MUC16	19	8966769	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08	3510847	8966769	50162214	77	25265											
PRR12	57479	broad.mit.edu	37	chr19	50099696	50099696	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagaggtaccacctgcagAgtgtcatccgcaccagtgcc	9	6	10	16	1	1	2	1	0	0	2	2	2	2	2	6	1	3	3	6	1	1	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr19:50099696A>T	uc002poo.3	+	4	2104	c.2104A>T	c.(2104-2106)AGT>TGT	p.S702C		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CCACCTGCAGAGTGTCATCCG	0.657													14	20					0	0	0	0	T	50099696	T	T	50099696	3	4	140	1	0	0	0	0	1	0	0	0	12646	304	11	5	2118	5	PRR12	19	50099696	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08	41132927	50099696	9029287	78	25266											
ZNF543	125919	broad.mit.edu	37	chr19	57839395	57839395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcacatggaccagttacaGatgccttgattcgcgaagag	12	10	10	9	2	1	3	1	1	0	2	2	5	1	4	2	1	2	1	2	1	2	4			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr19:57839395G>A	uc002qoi.1	+	4	910	c.565G>A	c.(565-567)GAT>AAT	p.D189N		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ACCAGTTACAGATGCCTTGAT	0.403													29	81					0	0	0	0	A	57839395	A	A	57839395	3	1	140	1	0	0	0	0	1	0	0	0	18043	942	33	2	579	2	ZNF543	19	57839395	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	7739699	57839395	1289588	79	25267											
ANGPT4	51378	broad.mit.edu	37	chr20	896725	896725	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttgggcagcaagaaggtgtAgctacagtggccgtgctgga	9	8	16	8	1	0	1	0	0	0	1	0	2	0	2	1	4	4	5	1	4	4	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr20:896725A>C	uc002wei.2	-	1	236	c.133T>G	c.(133-135)TAC>GAC	p.Y45D	ANGPT4_uc010zpn.1_Missense_Mutation_p.Y39D	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	45					anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						AAGAAGGTGTAGCTACAGTGG	0.607													19	65					0	0	0	0	C	896725	C	C	896725	3	2	140	1	0	0	0	0	1	0	0	0	612	420	15	5	1414	5	ANGPT4	20	896725	Missense_Mutation	SNP	A	TCGA-CR-7369-01A-11D-2129-08		896725	62128795	80	25268											
C20orf186	149954	broad.mit.edu	37	chr20	31671216	31671216	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gacttccatgtccgaggaccCcccccagtatataccaacgg	10	7	8	16	2	0	0	0	0	0	0	2	3	2	1	7	2	2	1	7	2	4	4	rs145261889	byFrequency	TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr20:31671216C>A	uc010zue.1	+	3	228	c.213C>A	c.(211-213)CCC>CCA	p.P71P		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	71						cytoplasm|extracellular region	lipid binding				0						TCCGAGGACCCCCCCCAGTAT	0.488													39	113					7.05121e-23	8.65376e-23	1	0	A	31671216	A	A	31671216	2	1	140	1	0	0	0	0	0	0	0	1	2108	610	22	4		4	C20orf186	20	31671216	Silent	SNP	C	TCGA-CR-7369-01A-11D-2129-08	30774491	31671216	31354304	81	25269											
KIAA1755	85449	broad.mit.edu	37	chr20	36841569	36841569	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctggggggctgctgccGgaagaaggtggtggcaagca	7	6	19	9	1	0	1	0	0	0	1	0	2	0	2	2	7	4	4	2	7	3	0			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr20:36841569G>A	uc002xhy.1	-	14	3750	c.3478C>T	c.(3478-3480)CGG>TGG	p.R1160W	KIAA1755_uc002xhv.1_Missense_Mutation_p.R224W|KIAA1755_uc002xhw.1_Missense_Mutation_p.R215W|KIAA1755_uc002xhx.1_Missense_Mutation_p.R438W	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	1160										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GGCTGCTGCCGGAAGAAGGTG	0.647													17	74					0	0	0	0	A	36841569	A	A	36841569	3	1	140	1	0	0	0	0	1	0	0	0	8296	1115	39	1	128	1	KIAA1755	20	36841569	Missense_Mutation	SNP	G	TCGA-CR-7369-01A-11D-2129-08	5170353	36841569	26183951	82	25270											
PPP1R16B	26051	broad.mit.edu	37	chr20	37464808	37464808	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggcctcgctgaggaacgaCgccgaggaaggtaggcccct	9	4	16	12	4	0	1	0	1	0	0	1	6	0	3	4	5	1	2	4	5	3	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr20:37464808C>A	uc002xje.2	+	2	429	c.240C>A	c.(238-240)GAC>GAA	p.D80E	PPP1R16B_uc010ggc.2_Missense_Mutation_p.D80E	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	80					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TGAGGAACGACGCCGAGGAAG	0.652													12	41					6.72482e-11	7.72639e-11	1	0	A	37464808	A	A	37464808	3	1	140	1	0	0	0	0	1	0	0	0	12426	535	19	3	242	3	PPP1R16B	20	37464808	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08	623239	37464808	25560712	83	25271											
YWHAB	7529	broad.mit.edu	37	chr20	43530339	43530339	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctacaagaatgtggtaggCgcccgccgctcttcctggcg	6	8	13	14	4	1	1	0	0	1	1	2	1	2	1	4	3	1	2	4	3	4	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr20:43530339C>T	uc002xmt.2	+	3	447	c.165C>T	c.(163-165)GGC>GGT	p.G55G	YWHAB_uc002xmu.2_Silent_p.G55G	NM_003404	NP_003395	P31946	1433B_HUMAN	tyrosine 3-monooxygenase/tryptophan	55					activation of MAPKK activity|activation of pro-apoptotic gene products|axon guidance|cytoplasmic sequestering of protein|epidermal growth factor receptor signaling pathway|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|mRNA metabolic process|negative regulation of protein dephosphorylation|nerve growth factor receptor signaling pathway|Ras protein signal transduction	centrosome|cytosol|melanosome|perinuclear region of cytoplasm	histone deacetylase binding|phosphoserine binding|protein domain specific binding			kidney(2)|ovary(1)|breast(1)	4		Myeloproliferative disorder(115;0.0122)				ATGTGGTAGGCGCCCGCCGCT	0.512													23	41					0	0	0	0	T	43530339	T	T	43530339	2	4	140	1	0	0	0	0	0	0	0	1	17569	755	27	1		1	YWHAB	20	43530339	Silent	SNP	C	TCGA-CR-7369-01A-11D-2129-08	6065531	43530339	19495181	84	25272											
DIP2A	23181	broad.mit.edu	37	chr21	47977603	47977603	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacaaggcccgcgtcaccttCtgctcctactctgtgatgga	7	11	9	14	2	3	1	1	1	2	0	4	2	4	2	3	2	3	1	3	2	3	3			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr21:47977603C>G	uc002zjo.2	+	31	3918	c.3735C>G	c.(3733-3735)TTC>TTG	p.F1245L	DIP2A_uc011afz.1_Missense_Mutation_p.F1241L|DIP2A_uc002zjr.2_Missense_Mutation_p.F212L	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	1245					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GCGTCACCTTCTGCTCCTACT	0.637													8	18					0	0	0	0	G	47977603	G	G	47977603	3	3	140	1	0	0	0	0	1	0	0	0	4549	912	32	2	3970	2	DIP2A	21	47977603	Missense_Mutation	SNP	C	TCGA-CR-7369-01A-11D-2129-08		47977603	152292	85	25273											
SFI1	9814	broad.mit.edu	37	chr22	32009447	32009447	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctccaggagggtgccacGcggctcctgcgctttgcagc	4	8	13	16	3	0	0	0	0	0	0	3	1	3	1	4	3	4	3	4	3	0	1			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chr22:32009447G>T	uc003ale.2	+	26	3066	c.2673G>T	c.(2671-2673)ACG>ACT	p.T891T	SFI1_uc003alf.2_Silent_p.T860T|SFI1_uc003alg.2_Silent_p.T809T|SFI1_uc011alp.1_Silent_p.T797T|SFI1_uc011alq.1_Silent_p.T836T|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA|SFI1_uc003ali.2_5'Flank|SFI1_uc003alj.2_5'Flank	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	891					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						AGGGTGCCACGCGGCTCCTGC	0.682													7	23					2.0095e-06	2.17026e-06	1	0	T	32009447	T	T	32009447	2	4	140	1	0	0	0	0	0	0	0	1	14221	1074	38	3		3	SFI1	22	32009447	Silent	SNP	G	TCGA-CR-7369-01A-11D-2129-08		32009447	19295119	86	25274											
SOX3	6658	broad.mit.edu	37	chrX	139586674	139586674	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgtcgatgaatggtcgcttCtcggcgtcggtcagcagttt	5	13	13	10	6	2	1	1	1	1	0	7	2	2	1	0	3	1	3	0	3	1	2			TCGA-CR-7369-01A-11D-2129-08	TCGA-CR-7369-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	f16a5c08-c9f8-442e-ba13-45681cacda40	1455ebfe-ee2b-43e5-a4bb-993118f35835	g.chrX:139586674C>T	uc004fbd.1	-	1	552	c.552G>A	c.(550-552)GAG>GAA	p.E184E		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	184	HMG box.				face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					ATGGTCGCTTCTCGGCGTCGG	0.612													4	50					0	0	0	0	T	139586674	T	T	139586674	2	4	140	1	0	0	0	0	0	0	0	1	15015	912	32	2		2	SOX3	23	139586674	Silent	SNP	C	TCGA-CR-7369-01A-11D-2129-08		139586674	15683886	87	25275											
KIAA0562	9731	broad.mit.edu	37	chr1	3740094	3740094	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttttgtcacattccgtcagCaagtgctccgtcagactgga	8	13	9	11	2	3	1	3	0	0	1	5	2	5	2	2	1	2	2	2	1	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:3740094C>A	uc001aky.2	-	19	2756	c.2397G>T	c.(2395-2397)TTG>TTT	p.L799F	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	799						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		ATTCCGTCAGCAAGTGCTCCG	0.502													35	30					1.30998e-17	1.77818e-17	1	0	A	3740094	A	A	3740094	3	1	141	1	0	0	0	0	1	0	0	0	8223	709	25	4	396	4	KIAA0562	1	3740094	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08		3740094	245510527	1	25276											
CA6	765	broad.mit.edu	37	chr1	9019024	9019024	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctatgatatagcccaagatgCgccggatggtttggctgtac	9	11	12	9	2	0	2	0	1	0	1	0	3	0	3	2	3	3	3	2	3	5	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:9019024C>A	uc001apm.2	+	4	488	c.464C>A	c.(463-465)GCG>GAG	p.A155E	CA6_uc009vmn.2_Missense_Mutation_p.A95E	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	155					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCAAGATGCGCCGGATGGT	0.428													103	52					4.60726e-43	7.20069e-43	1	0	A	9019024	A	A	9019024	3	1	141	1	0	0	0	0	1	0	0	0	2533	768	27	3	478	3	CA6	1	9019024	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	5278930	9019024	240231597	2	25277											
CROCC	9696	broad.mit.edu	37	chr1	17295649	17295649	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcagggaccctgcagctGaccgtggagcggctgaatgg	9	5	17	10	2	0	2	0	2	0	0	0	4	0	4	2	5	3	4	2	5	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:17295649G>T	uc001azt.2	+	32	5184	c.5115G>T	c.(5113-5115)CTG>CTT	p.L1705L	CROCC_uc001azu.2_Silent_p.L1008L|CROCC_uc001azv.2_Silent_p.L41L	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	1705					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CCCTGCAGCTGACCGTGGAGC	0.667													3	11					0.004672	0.00482335	1	0	T	17295649	T	T	17295649	2	4	141	1	0	0	0	0	0	0	0	1	3908	1277	45	2		2	CROCC	1	17295649	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	8276625	17295649	231954972	3	25278											
SH3BGRL3	83442	broad.mit.edu	37	chr1	26607338	26607338	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtggacatctcccaggacaAcgccctgagggatgagatgc	11	6	13	11	1	1	2	0	2	1	1	2	6	1	5	2	3	2	0	2	3	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:26607338A>G	uc001blu.2	+	2	565	c.131A>G	c.(130-132)AAC>AGC	p.N44S		NM_031286	NP_112576	Q9H299	SH3L3_HUMAN	SH3 domain binding glutamic acid-rich protein	44	Glutaredoxin.				cell redox homeostasis	cytoplasm|nucleus	electron carrier activity|protein disulfide oxidoreductase activity				0		all_cancers(24;1.16e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.22e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00751)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCAGGACAACGCCCTGAGG	0.617													18	10					0	0	0	0	G	26607338	G	G	26607338	3	3	141	1	0	0	0	0	1	0	0	0	14308	43	2	5	137	5	SH3BGRL3	1	26607338	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	9311689	26607338	222643283	4	25279											
CSMD2	114784	broad.mit.edu	37	chr1	34123627	34123627	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcacttccctgcagcgCgtagccagggtcacactgga	7	8	11	15	2	2	0	1	0	1	0	3	1	3	1	2	2	4	3	2	2	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:34123627C>T	uc001bxn.1	-	27	4275	c.4246G>A	c.(4246-4248)GCG>ACG	p.A1416T	CSMD2_uc001bxm.1_Missense_Mutation_p.A1456T|CSMD2_uc001bxo.1_Missense_Mutation_p.A329T	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1416	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCCTGCAGCGCGTAGCCAGGG	0.592													44	22					0	0	0	0	T	34123627	T	T	34123627	3	4	141	1	0	0	0	0	1	0	0	0	3962	768	27	1	6389	1	CSMD2	1	34123627	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	7516289	34123627	215126994	5	25280											
CSMD2	114784	broad.mit.edu	37	chr1	34174731	34174731	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttcgaatgccctggctttCagctgaattcccttccctgg	6	13	9	13	1	1	1	1	1	0	0	4	2	3	1	3	2	2	3	3	2	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:34174731C>T	uc001bxn.1	-	22	3443	c.3414G>A	c.(3412-3414)CTG>CTA	p.L1138L	CSMD2_uc001bxm.1_Silent_p.L1178L|CSMD2_uc001bxo.1_Silent_p.L51L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1138	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCCTGGCTTTCAGCTGAATTC	0.443													8	60					0	0	0	0	T	34174731	T	T	34174731	2	4	141	1	0	0	0	0	0	0	0	1	3962	813	29	2		2	CSMD2	1	34174731	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	51104	34174731	215075890	6	25281											
TMEM125	128218	broad.mit.edu	37	chr1	43738818	43738818	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgccgcccctgcccctgctcGgccgctggccgccatgctgt	1	7	12	21	5	0	0	0	0	0	0	1	0	0	0	8	2	3	3	8	2	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:43738818G>T	uc001cir.2	+	4	995	c.425G>T	c.(424-426)CGG>CTG	p.R142L	EBNA1BP2_uc001cio.2_5'Flank|TMEM125_uc001cis.2_Missense_Mutation_p.R142L	NM_144626	NP_653227	Q96AQ2	TM125_HUMAN	transmembrane protein 125	142						integral to membrane				breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCCCCTGCTCGGCCGCTGGCC	0.706													9	5					2.74318e-10	3.34568e-10	1	0	T	43738818	T	T	43738818	3	4	141	1	0	0	0	0	1	0	0	0	16103	1116	39	3	427	3	TMEM125	1	43738818	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	9564087	43738818	205511803	7	25282											
PCSK9	255738	broad.mit.edu	37	chr1	55518372	55518372	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctggcaggggtggtcagcgGccgggatgccggcgtggcca	4	5	20	12	4	1	0	1	0	0	0	1	1	1	1	4	8	2	1	4	8	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:55518372G>A	uc001cyf.1	+	5	998	c.707G>A	c.(706-708)GGC>GAC	p.G236D	PCSK9_uc010ool.1_RNA|PCSK9_uc010oom.1_RNA	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	236	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GTGGTCAGCGGCCGGGATGCC	0.637													25	11					0	0	0	0	A	55518372	A	A	55518372	3	1	141	1	0	0	0	0	1	0	0	0	11660	1203	42	4	725	4	PCSK9	1	55518372	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	11779554	55518372	193732249	8	25283											
INADL	10207	broad.mit.edu	37	chr1	62340990	62340990	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtcaacaaggcagatttGacgacctggaaaatcttaat	16	9	8	8	1	2	2	1	1	1	1	2	4	2	3	1	2	1	1	1	2	5	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:62340990G>T	uc001dab.2	+	21	3025	c.2911G>T	c.(2911-2913)GAC>TAC	p.D971Y	INADL_uc009waf.1_Missense_Mutation_p.D971Y|INADL_uc001daa.2_Missense_Mutation_p.D971Y|INADL_uc001dad.3_Missense_Mutation_p.D668Y|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	971					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						AGGCAGATTTGACGACCTGGA	0.338													34	13					7.83172e-31	1.19101e-30	1	0	T	62340990	T	T	62340990	3	4	141	1	0	0	0	0	1	0	0	0	7770	1290	45	2	2989	2	INADL	1	62340990	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	6822618	62340990	186909631	9	25284											
C1orf173	127254	broad.mit.edu	37	chr1	75072536	75072536	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcagtgctcttttctttcCtagatttcggcaaagacggt	7	16	8	10	2	3	2	1	0	3	2	6	2	4	2	1	2	1	2	1	2	2	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:75072536C>A	uc001dgg.2	-	10	1457	c.1238G>T	c.(1237-1239)AGG>ATG	p.R413M	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.R207M	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	413										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTTTTCTTTCCTAGATTTCGG	0.408													47	34					2.47907e-22	3.58413e-22	1	0	A	75072536	A	A	75072536	3	1	141	1	0	0	0	0	1	0	0	0	2023	681	24	4	3374	4	C1orf173	1	75072536	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	12731546	75072536	174178085	10	25285											
WDR63	126820	broad.mit.edu	37	chr1	85561694	85561694	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcattgctggaggctgtatCaatgggcaggtacttaacag	11	11	12	7	0	2	0	2	0	0	0	2	1	2	1	0	4	3	5	0	4	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:85561694C>G	uc001dkt.2	+	11	1445	c.1254C>G	c.(1252-1254)ATC>ATG	p.I418M	WDR63_uc009wcl.2_Missense_Mutation_p.I379M	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	418	WD 1.									upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		GAGGCTGTATCAATGGGCAGG	0.393													31	19					0	0	0	0	G	85561694	G	G	85561694	3	3	141	1	0	0	0	0	1	0	0	0	17382	816	29	2	1292	2	WDR63	1	85561694	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	10489158	85561694	163688927	11	25286											
HFM1	164045	broad.mit.edu	37	chr1	91843694	91843694	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagttttcattctgctaactAcaacttcaagagttggacca	12	13	6	10	0	3	1	2	0	1	1	3	2	3	2	1	1	4	3	1	1	4	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:91843694A>G	uc001doa.3	-	11	1383	c.1283T>C	c.(1282-1284)GTA>GCA	p.V428A	HFM1_uc010osu.1_Missense_Mutation_p.V107A|HFM1_uc010osv.1_Missense_Mutation_p.V112A|HFM1_uc001doc.1_Missense_Mutation_p.V428A	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	428	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TCTGCTAACTACAACTTCAAG	0.318													19	16					0	0	0	0	G	91843694	G	G	91843694	3	3	141	1	0	0	0	0	1	0	0	0	7122	391	14	5	3140	5	HFM1	1	91843694	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	6282000	91843694	157406927	12	25287											
COL11A1	1301	broad.mit.edu	37	chr1	103462681	103462681	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttctttcccaggatgaccCtatatttagcaaaaacatac	13	12	4	12	0	1	1	0	1	1	0	2	2	2	2	3	1	3	1	3	1	6	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:103462681C>T	uc001dul.2	-	26	2515	c.2197_splice	c.e26-1	p.G733_splice	COL11A1_uc001duk.2_Splice_Site|COL11A1_uc001dum.2_Splice_Site_p.G745_splice|COL11A1_uc001dun.2_Splice_Site_p.G694_splice|COL11A1_uc009weh.2_Splice_Site_p.G617_splice	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGGATGACCCTATATTTAGC	0.318													100	51					0	0	0	0	T	103462681	T	T	103462681	5	4	141	1	0	0	0	0	0	0	1	0	3682	695	24	4	3392	4	COL11A1	1	103462681	Splice_Site	SNP	C	TCGA-CR-7370-01A-11D-2129-08	11618987	103462681	145787940	13	25288											
COL11A1	1301	broad.mit.edu	37	chr1	103487279	103487279	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttacaggctcaaccactgctGgttctcctttctgtcctttc	5	16	6	14	0	3	0	1	0	2	0	6	0	4	0	3	2	3	3	3	2	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:103487279G>T	uc001dul.2	-	9	1610	c.1292C>A	c.(1291-1293)CCA>CAA	p.P431Q	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.P443Q|COL11A1_uc001dun.2_Missense_Mutation_p.P392Q|COL11A1_uc009weh.2_Missense_Mutation_p.P315Q	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	431	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AACCACTGCTGGTTCTCCTTT	0.353													29	20					1.99505e-19	2.79612e-19	1	0	T	103487279	T	T	103487279	3	4	141	1	0	0	0	0	1	0	0	0	3682	1348	47	4	4364	4	COL11A1	1	103487279	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	24598	103487279	145763342	14	25289											
PDE4DIP	9659	broad.mit.edu	37	chr1	145075791	145075791	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	taaggcgtgtagtgagcccgGcgggacgcgcgacagcagca	9	4	17	11	6	0	1	0	1	0	0	0	3	0	2	1	3	3	3	1	3	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:145075791G>T	uc001emh.2	-	1	289	c.72C>A	c.(70-72)CGC>CGA	p.R24R	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Silent_p.R24R|PDE4DIP_uc001emk.2_Silent_p.R24R	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:Variant_position_missing_in_Q5VU43_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGTGAGCCCGGCGGGACGCGC	0.716			T	PDGFRB	MPD								17	85					1.36565e-18	1.88516e-18	1	0	T	145075791	T	T	145075791	2	4	141	1	0	0	0	0	0	0	0	1	11697	1190	42	4		4	PDE4DIP	1	145075791	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	41588512	145075791	104174830	15	25290											
CHD1L	9557	broad.mit.edu	37	chr1	146747865	146747865	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctcaccaacatgatcataGaaggaggccattttactctg	13	10	8	10	0	3	2	2	1	1	1	3	3	3	3	2	2	3	1	2	2	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:146747865G>C	uc001epm.3	+	14	1546	c.1483G>C	c.(1483-1485)GAA>CAA	p.E495Q	uc001epp.2_Intron|CHD1L_uc001epn.3_Missense_Mutation_p.E382Q|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Missense_Mutation_p.E401Q|CHD1L_uc010ozp.1_Missense_Mutation_p.E214Q|CHD1L_uc001epo.3_Missense_Mutation_p.E291Q|CHD1L_uc010ozq.1_Missense_Mutation_p.E68Q|CHD1L_uc009wji.2_Missense_Mutation_p.E214Q	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	495	Helicase C-terminal.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					CATGATCATAGAAGGAGGCCA	0.453													6	102					0	0	0	0	C	146747865	C	C	146747865	3	2	141	1	0	0	0	0	1	0	0	0	3339	943	33	2	1537	2	CHD1L	1	146747865	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1672074	146747865	102502756	16	25291											
FAM63A	55793	broad.mit.edu	37	chr1	150974945	150974945	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcttggtctgctggctccCgttctctagcctccccatca	5	12	8	16	1	3	0	1	0	2	0	6	0	5	0	4	2	3	4	4	2	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:150974945C>A	uc001ewf.2	-	3	1833	c.149G>T	c.(148-150)CGG>CTG	p.R50L	FAM63A_uc001ewc.2_Intron|FAM63A_uc010pcm.1_Intron|FAM63A_uc001ewd.2_Intron|FAM63A_uc001ewe.2_Intron|FAM63A_uc010pcn.1_Missense_Mutation_p.R98L|FAM63A_uc001ewg.2_Missense_Mutation_p.R50L	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	50							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGCTGGCTCCCGTTCTCTAGC	0.592													20	248					7.45023e-12	9.4318e-12	1	0	A	150974945	A	A	150974945	3	1	141	1	0	0	0	0	1	0	0	0	5628	652	23	3	1296	3	FAM63A	1	150974945	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4227080	150974945	98275676	17	25292											
S100A11	6282	broad.mit.edu	37	chr1	152005294	152005294	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaggacaccagggtccttCtggttctgcagagaaaataa	13	9	10	9	0	3	1	1	0	2	1	4	3	4	2	2	3	1	2	2	3	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:152005294C>G	uc001ezn.2	-	3	282	c.162G>C	c.(160-162)CAG>CAC	p.Q54H	uc001ezm.1_Intron	NM_005620	NP_005611	P31949	S10AB_HUMAN	S100 calcium binding protein A11	54					negative regulation of cell proliferation|negative regulation of DNA replication|signal transduction	cytoplasm|nucleus|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|S100 beta binding				0	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CAGGGTCCTTCTGGTTCTGCA	0.269													29	52					0	0	0	0	G	152005294	G	G	152005294	3	3	141	1	0	0	0	0	1	0	0	0	13838	912	32	2	159	2	S100A11	1	152005294	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1030349	152005294	97245327	18	25293											
DCST2	127579	broad.mit.edu	37	chr1	155004083	155004083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acagagcgccagtttgaaggGcatgagcacgtaacacaggt	13	6	13	9	2	0	3	0	2	0	1	0	3	0	3	1	2	3	4	1	2	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:155004083G>A	uc001fgm.2	-	4	786	c.706C>T	c.(706-708)CCC>TCC	p.P236S	DCST2_uc009wpb.2_RNA|DCST1_uc010per.1_5'Flank|DCST1_uc001fgn.1_5'Flank|DCST1_uc010pes.1_5'Flank	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	236	Helical; (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AGTTTGAAGGGCATGAGCACG	0.512													32	76					0	0	0	0	A	155004083	A	A	155004083	3	1	141	1	0	0	0	0	1	0	0	0	4320	1203	42	4	1663	4	DCST2	1	155004083	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2998789	155004083	94246538	19	25294											
SYT11	23208	broad.mit.edu	37	chr1	155837912	155837912	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catgctcaaaggcatcagcaTatacccagagaccctcagca	14	6	7	14	0	3	1	3	0	0	1	3	2	3	1	2	1	4	4	2	1	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:155837912T>C	uc001fmg.2	+	2	454	c.191T>C	c.(190-192)ATA>ACA	p.I64T	SYT11_uc010pgq.1_Intron	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	64	Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			GGCATCAGCATATACCCAGAG	0.502													33	70					0	0	0	0	C	155837912	C	C	155837912	3	2	141	1	0	0	0	0	1	0	0	0	15533	1406	49	5	197	5	SYT11	1	155837912	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	833829	155837912	93412709	20	25295											
CD1E	913	broad.mit.edu	37	chr1	158325824	158325824	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaccctggatgtggcggctgGggaggcagctggcctgtcct	5	8	17	11	1	0	0	0	0	0	0	1	2	1	2	3	7	2	3	3	7	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:158325824G>C	uc001fse.2	+	4	1072	c.833G>C	c.(832-834)GGG>GCG	p.G278A	CD1E_uc010pid.1_Missense_Mutation_p.G276A|CD1E_uc010pie.1_Missense_Mutation_p.G179A|CD1E_uc010pif.1_Missense_Mutation_p.G89A|CD1E_uc001fsd.2_Intron|CD1E_uc001fsk.2_Missense_Mutation_p.G188A|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Missense_Mutation_p.G89A|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.G278A|CD1E_uc001fry.2_Intron|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Missense_Mutation_p.G89A|CD1E_uc001fsi.2_Intron|CD1E_uc009wsv.2_Missense_Mutation_p.G179A|CD1E_uc001frz.2_Missense_Mutation_p.G188A|CD1E_uc009wsw.2_Missense_Mutation_p.G36A	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	278	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					GTGGCGGCTGGGGAGGCAGCT	0.607													39	64					0	0	0	0	C	158325824	C	C	158325824	3	2	141	1	0	0	0	0	1	0	0	0	2993	1232	43	4	847	4	CD1E	1	158325824	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2487912	158325824	90924797	21	25296											
OR10K1	391109	broad.mit.edu	37	chr1	158435444	158435444	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagctgctctttgttatcttCctgctcctctacctgttcac	4	17	5	15	0	4	0	1	0	3	0	6	0	6	0	3	0	4	5	3	0	2	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:158435444C>T	uc010pij.1	+	1	93	c.93C>T	c.(91-93)TTC>TTT	p.F31F		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TTGTTATCTTCCTGCTCCTCT	0.517													40	65					0	0	0	0	T	158435444	T	T	158435444	2	4	141	1	0	0	0	0	0	0	0	1	10967	854	30	2		2	OR10K1	1	158435444	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	109620	158435444	90815177	22	25297											
SPTA1	6708	broad.mit.edu	37	chr1	158582607	158582607	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagcaaccagaatcggacCtgcttcatgtcttctttggt	9	12	10	10	1	3	1	1	0	2	1	4	3	3	3	2	3	3	2	2	3	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:158582607C>T	uc001fst.1	-	51	7333	c.7134G>A	c.(7132-7134)CAG>CAA	p.Q2378Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2378	EF-hand 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGAATCGGACCTGCTTCATGT	0.458													26	51					0	0	0	0	T	158582607	T	T	158582607	2	4	141	1	0	0	0	0	0	0	0	1	15182	695	24	4		4	SPTA1	1	158582607	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	147163	158582607	90668014	23	25298											
SPTA1	6708	broad.mit.edu	37	chr1	158627344	158627344	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgatccatgtttctgcttCatgcaggtcagccaggtact	7	14	9	11	0	4	1	2	1	2	0	5	1	5	1	2	2	4	4	2	2	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:158627344C>G	uc001fst.1	-	19	2927	c.2728G>C	c.(2728-2730)GAA>CAA	p.E910Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	910	Spectrin 10.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GTTTCTGCTTCATGCAGGTCA	0.473													71	111					0	0	0	0	G	158627344	G	G	158627344	3	3	141	1	0	0	0	0	1	0	0	0	15182	835	29	2	4667	2	SPTA1	1	158627344	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	44737	158627344	90623277	24	25299											
DARC	2532	broad.mit.edu	37	chr1	159175930	159175930	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccaaggggctgaagaaggCattgggtatggggccaggcc	10	5	18	8	0	0	2	0	1	0	1	0	2	0	2	3	7	1	3	3	7	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:159175930C>A	uc001fto.2	+	2	941	c.701C>A	c.(700-702)GCA>GAA	p.A234E	DARC_uc001ftp.3_Missense_Mutation_p.A236E	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	234	Cytoplasmic (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					CTGAAGAAGGCATTGGGTATG	0.542													26	62					6.12954e-19	8.47726e-19	1	0	A	159175930	A	A	159175930	3	1	141	1	0	0	0	0	1	0	0	0	4257	710	25	4	734	4	DARC	1	159175930	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	548586	159175930	90074691	25	25300											
DEDD	9191	broad.mit.edu	37	chr1	161093691	161093691	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggctctgggggtcacatagCgaattgatgtctcctccaga	8	10	13	10	1	3	2	1	1	2	1	5	3	4	2	2	3	1	1	2	3	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:161093691C>G	uc001fxz.2	-	4	544	c.371G>C	c.(370-372)CGC>CCC	p.R124P	NIT1_uc001fxw.2_Intron|DEDD_uc009wty.2_Missense_Mutation_p.R124P|DEDD_uc001fya.2_Missense_Mutation_p.R124P|DEDD_uc001fyb.2_Missense_Mutation_p.R124P|DEDD_uc010pkb.1_Missense_Mutation_p.R81P|DEDD_uc001fyc.2_5'UTR	NM_001039712	NP_001034801	O75618	DEDD_HUMAN	death effector domain-containing protein	124					apoptosis|induction of apoptosis via death domain receptors|negative regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding				0	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			GGTCACATAGCGAATTGATGT	0.483													37	97					0	0	0	0	G	161093691	G	G	161093691	3	3	141	1	0	0	0	0	1	0	0	0	4401	768	27	3	597	3	DEDD	1	161093691	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1917761	161093691	88156930	26	25301											
DDR2	4921	broad.mit.edu	37	chr1	162731083	162731083	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgctctgaagccagtgagtGggaacctaatgccatttcct	9	10	10	12	1	1	2	0	2	1	0	2	3	2	3	5	1	3	1	5	1	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:162731083G>T	uc001gcf.2	+	10	1403	c.938G>T	c.(937-939)TGG>TTG	p.W313L	DDR2_uc001gcg.2_Missense_Mutation_p.W313L	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	313	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GCCAGTGAGTGGGAACCTAAT	0.527													28	30					2.12542e-12	2.71416e-12	1	0	T	162731083	T	T	162731083	3	4	141	1	0	0	0	0	1	0	0	0	4354	1357	47	4	964	4	DDR2	1	162731083	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1637392	162731083	86519538	27	25302											
C1orf110	339512	broad.mit.edu	37	chr1	162824618	162824618	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcctgccctggatgatgaGgattccccatgcccaaatat	9	12	8	12	0	0	2	0	2	0	0	2	4	2	4	5	2	2	0	5	2	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:162824618G>A	uc001gck.2	-	4	1021	c.846C>T	c.(844-846)TCC>TCT	p.S282S	C1orf110_uc009wuw.1_Intron|C1orf110_uc009wux.1_Silent_p.S281S	NM_178550	NP_848645	Q86UF4	CA110_HUMAN	hypothetical protein LOC339512	282											0						TGGATGATGAGGATTCCCCAT	0.473													50	71					0	0	0	0	A	162824618	A	A	162824618	2	1	141	1	0	0	0	0	0	0	0	1	1992	987	35	4		4	C1orf110	1	162824618	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	93535	162824618	86426003	28	25303											
FAM5B	57795	broad.mit.edu	37	chr1	177226407	177226407	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatcgggggcagtgggaacAgcacagctgtgtccctggag	9	7	16	9	1	0	0	0	0	0	0	2	2	1	2	1	4	3	3	1	4	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:177226407A>T	uc001glf.2	+	4	868	c.556A>T	c.(556-558)AGC>TGC	p.S186C	FAM5B_uc010pna.1_5'UTR|FAM5B_uc001glg.2_Missense_Mutation_p.S81C	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	186						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CAGTGGGAACAGCACAGCTGT	0.557													16	33					0	0	0	0	T	177226407	T	T	177226407	3	4	141	1	0	0	0	0	1	0	0	0	5625	188	7	5	566	5	FAM5B	1	177226407	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	14401789	177226407	72024214	29	25304											
CEP350	9857	broad.mit.edu	37	chr1	180006140	180006140	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacgccattgaggagtcGgtgcgccaactgtcagatgt	9	9	13	10	3	1	3	1	2	0	1	2	4	1	4	2	2	3	0	2	2	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:180006140G>T	uc001gnt.2	+	17	4409	c.4026G>T	c.(4024-4026)TCG>TCT	p.S1342S	CEP350_uc009wxl.2_Silent_p.S1341S|CEP350_uc001gnu.2_Silent_p.S1175S	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1342						centrosome|nucleus|spindle				ovary(4)	4						TTGAGGAGTCGGTGCGCCAAC	0.468													7	7					5.4927e-09	6.48334e-09	1	0	T	180006140	T	T	180006140	2	4	141	1	0	0	0	0	0	0	0	1	3269	1103	39	3		3	CEP350	1	180006140	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2779733	180006140	69244481	30	25305											
CACNA1E	777	broad.mit.edu	37	chr1	181690908	181690908	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgtagatcctgacgggtgaGgactggaatgaggtgatgta	10	11	16	4	1	0	5	0	4	0	1	1	7	1	7	1	4	0	2	1	4	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:181690908G>A	uc001gow.2	+	16	2136	c.1971G>A	c.(1969-1971)GAG>GAA	p.E657E	CACNA1E_uc009wxs.2_Silent_p.E564E	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	657	Extracellular (Potential).|II.	Calcium ion selectivity and permeability (By similarity).			energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TGACGGGTGAGGACTGGAATG	0.542													54	122					0	0	0	0	A	181690908	A	A	181690908	2	1	141	1	0	0	0	0	0	0	0	1	2554	991	35	4		4	CACNA1E	1	181690908	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1684768	181690908	67559713	31	25306											
UCHL5	51377	broad.mit.edu	37	chr1	193028325	193028325	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggttctcaccgaatcctttAatgagctcggtgaagacccc	9	11	9	12	2	1	3	1	2	1	1	4	4	2	3	4	2	1	2	4	2	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:193028325A>C	uc001gsm.2	-	1	197	c.66T>G	c.(64-66)ATT>ATG	p.I22M	UCHL5_uc001gsn.2_RNA|UCHL5_uc001gso.2_Missense_Mutation_p.I22M|UCHL5_uc010pov.1_RNA|UCHL5_uc001gsp.2_Missense_Mutation_p.I22M|UCHL5_uc001gsq.2_Missense_Mutation_p.I22M|UCHL5_uc010pow.1_Intron|UCHL5_uc010pox.1_Translation_Start_Site|UCHL5_uc001gsr.1_3'UTR|TROVE2_uc001gst.1_5'Flank|TROVE2_uc001gss.2_5'Flank|TROVE2_uc001gsu.1_5'Flank|TROVE2_uc001gsv.1_5'Flank|TROVE2_uc001gsw.2_5'Flank|TROVE2_uc009wyp.2_5'Flank|TROVE2_uc009wyq.2_5'Flank	NM_015984	NP_057068	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	22					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3						CGAATCCTTTAATGAGCTCGG	0.677													14	7					0	0	0	0	C	193028325	C	C	193028325	3	2	141	1	0	0	0	0	1	0	0	0	16990	358	13	5	967	5	UCHL5	1	193028325	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	11337417	193028325	56222296	32	25307											
KCNT2	343450	broad.mit.edu	37	chr1	196227558	196227558	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgagttgcggtggttgctgcGgtggtgcccttgttctttgg	1	16	17	7	2	1	1	0	1	1	0	1	1	1	1	1	5	4	4	1	5	0	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:196227558G>T	uc001gtd.1	-	26	3037	c.2977C>A	c.(2977-2979)CGC>AGC	p.R993S	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.R926S|KCNT2_uc001gtf.1_Missense_Mutation_p.R969S|KCNT2_uc001gtg.1_RNA|KCNT2_uc001gth.1_Missense_Mutation_p.R497S	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	993	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TGGTTGCTGCGGTGGTGCCCT	0.468													40	79					6.48837e-15	8.58479e-15	1	0	T	196227558	T	T	196227558	3	4	141	1	0	0	0	0	1	0	0	0	8131	1116	39	3	442	3	KCNT2	1	196227558	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3199233	196227558	53023063	33	25308											
CRB1	23418	broad.mit.edu	37	chr1	197404354	197404354	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtttcattaataaacctCaggaagagcaatttctcaaa	16	12	6	7	0	3	1	3	0	1	1	4	2	3	2	1	2	2	2	1	2	6	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:197404354C>A	uc001gtz.2	+	9	3496	c.3361C>A	c.(3361-3363)CAG>AAG	p.Q1121K	CRB1_uc010poz.1_Missense_Mutation_p.Q1097K|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.Q1009K|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.Q602K|CRB1_uc001gub.1_Missense_Mutation_p.Q770K	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1121	Extracellular (Potential).|Laminin G-like 3.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TAATAAACCTCAGGAAGAGCA	0.398													30	72					1.13719e-10	1.40094e-10	1	0	A	197404354	A	A	197404354	3	1	141	1	0	0	0	0	1	0	0	0	3863	827	29	2	3395	2	CRB1	1	197404354	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1176796	197404354	51846267	34	25309											
SLC26A9	115019	broad.mit.edu	37	chr1	205900999	205900999	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccctcacctggatgatggCggtgaggcaggctagcgtag	7	7	15	12	2	1	2	1	2	0	0	1	3	1	3	3	5	1	3	3	5	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:205900999C>G	uc001hdq.2	-	5	655	c.541G>C	c.(541-543)GCC>CCC	p.A181P	SLC26A9_uc001hdp.2_Missense_Mutation_p.A181P	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	181	Helical; (Potential).					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TGGATGATGGCGGTGAGGCAG	0.562													21	31					0	0	0	0	G	205900999	G	G	205900999	3	3	141	1	0	0	0	0	1	0	0	0	14588	768	27	3	2198	3	SLC26A9	1	205900999	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	8496645	205900999	43349622	35	25310											
PIGR	5284	broad.mit.edu	37	chr1	207106357	207106357	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaatccacagatgctctgctCccatcggcttgatctcttgt	7	13	8	13	1	2	2	0	1	2	1	6	3	4	2	2	1	2	3	2	1	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:207106357C>A	uc001hez.2	-	7	2044	c.1860G>T	c.(1858-1860)GGG>GGT	p.G620G	PIGR_uc009xbz.2_Silent_p.G620G	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	620	Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ATGCTCTGCTCCCATCGGCTT	0.557													25	63					3.65163e-15	4.84899e-15	1	0	A	207106357	A	A	207106357	2	1	141	1	0	0	0	0	0	0	0	1	11952	842	30	2		2	PIGR	1	207106357	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1205358	207106357	42144264	36	25311											
CAMK1G	57172	broad.mit.edu	37	chr1	209781228	209781228	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtgctggcccagaaaccCtacagcaaggctgtggattg	11	7	13	10	0	0	1	0	0	0	1	0	3	0	2	2	3	4	3	2	3	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:209781228C>A	uc001hhd.2	+	7	687	c.585C>A	c.(583-585)CCC>CCA	p.P195P	CAMK1G_uc001hhf.3_Silent_p.P195P|CAMK1G_uc001hhe.2_Silent_p.P195P	NM_020439	NP_065172	Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	195	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		CCCAGAAACCCTACAGCAAGG	0.597													56	87					3.89483e-19	5.4483e-19	1	0	A	209781228	A	A	209781228	2	1	141	1	0	0	0	0	0	0	0	1	2610	668	24	4		4	CAMK1G	1	209781228	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2674871	209781228	39469393	37	25312											
C1orf107	27042	broad.mit.edu	37	chr1	210006693	210006693	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagacaactcttctttgaaAgcctctcaaggtcatagcac	12	10	8	11	0	4	2	2	1	3	1	5	3	4	2	1	2	3	1	1	2	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:210006693A>G	uc001hhr.1	+	4	628	c.552A>G	c.(550-552)AAA>AAG	p.K184K	C1orf107_uc009xcu.1_5'UTR	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	184					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		CTTCTTTGAAAGCCTCTCAAG	0.398													44	85					0	0	0	0	G	210006693	G	G	210006693	2	3	141	1	0	0	0	0	0	0	0	1	1990	69	3	5		5	C1orf107	1	210006693	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	225465	210006693	39243928	38	25313											
KCNH1	3756	broad.mit.edu	37	chr1	211093374	211093374	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcccaagacggagcagcCggacaacttttagagagctg	11	6	12	12	3	0	2	0	0	0	2	1	5	0	4	2	2	4	2	2	2	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:211093374C>A	uc001hib.2	-	7	1240	c.1070G>T	c.(1069-1071)CGG>CTG	p.R357L	KCNH1_uc001hic.2_Missense_Mutation_p.R330L	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	357	Helical; Voltage-sensor; Name=Segment S4; (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		ACGGAGCAGCCGGACAACTTT	0.567													29	62					6.38683e-12	8.12769e-12	1	0	A	211093374	A	A	211093374	3	1	141	1	0	0	0	0	1	0	0	0	8070	652	23	3	1919	3	KCNH1	1	211093374	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1086681	211093374	38157247	39	25314											
PROX1	5629	broad.mit.edu	37	chr1	214170119	214170119	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagagggcgaactcgtatGaagatgccatgatgcctttt	11	11	12	7	2	0	5	0	3	0	2	1	6	0	5	2	1	3	1	2	1	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:214170119G>A	uc001hkh.2	+	2	513	c.241G>A	c.(241-243)GAA>AAA	p.E81K	PROX1_uc001hkg.1_Missense_Mutation_p.E81K	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	81					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GAACTCGTATGAAGATGCCAT	0.478													9	71					0	0	0	0	A	214170119	A	A	214170119	3	1	141	1	0	0	0	0	1	0	0	0	12622	1291	45	2	243	2	PROX1	1	214170119	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3076745	214170119	35080502	40	25315											
PROX1	5629	broad.mit.edu	37	chr1	214170863	214170863	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaacaagccgaagcgagaaGgcaacaacaaagaaagagac	23	0	10	8	2	0	3	0	0	0	3	0	6	0	3	1	1	5	1	1	1	9	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:214170863G>A	uc001hkh.2	+	2	1257	c.985G>A	c.(985-987)GGC>AGC	p.G329S	PROX1_uc001hkg.1_Missense_Mutation_p.G329S	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	329					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GAAGCGAGAAGGCAACAACAA	0.493													9	50					0	0	0	0	A	214170863	A	A	214170863	3	1	141	1	0	0	0	0	1	0	0	0	12622	1000	35	4	987	4	PROX1	1	214170863	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	744	214170863	35079758	41	25316											
USH2A	7399	broad.mit.edu	37	chr1	215955411	215955411	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtggcacagccagcaacCgtgcaagctttcagctgata	10	8	11	12	1	1	1	1	1	0	0	1	1	1	1	2	2	6	5	2	2	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:215955411C>G	uc001hku.1	-	54	11100	c.10713G>C	c.(10711-10713)ACG>ACC	p.T3571T		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3571	Extracellular (Potential).|Fibronectin type-III 20.		T -> M (in USH2A).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGCCAGCAACCGTGCAAGCTT	0.443										HNSCC(13;0.011)			37	62					0	0	0	0	G	215955411	G	G	215955411	2	3	141	1	0	0	0	0	0	0	0	1	17104	639	23	3		3	USH2A	1	215955411	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1784548	215955411	33295210	42	25317											
USH2A	7399	broad.mit.edu	37	chr1	216258127	216258127	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttgttcttcagaactctGccaatccagaggttcccaaa	11	12	7	11	0	3	2	1	0	2	2	5	3	5	2	3	1	2	2	3	1	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:216258127G>T	uc001hku.1	-	25	5467	c.5080C>A	c.(5080-5082)CAG>AAG	p.Q1694K		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1694	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCAGAACTCTGCCAATCCAGA	0.433										HNSCC(13;0.011)			54	88					3.4597e-24	5.09229e-24	1	0	T	216258127	T	T	216258127	3	4	141	1	0	0	0	0	1	0	0	0	17104	1328	46	4	10720	4	USH2A	1	216258127	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	302716	216258127	32992494	43	25318											
SPATA17	128153	broad.mit.edu	37	chr1	217822275	217822275	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatgcagcagttaaaatccaAagctggtttcgaggatgtca	13	10	11	7	1	1	0	1	0	0	0	3	3	2	1	1	2	3	5	1	2	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:217822275A>T	uc001hlh.1	+	2	146	c.120A>T	c.(118-120)CAA>CAT	p.Q40H	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.Q40H	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	40	IQ 1.					cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TTAAAATCCAAAGCTGGTTTC	0.303													25	60					0	0	0	0	T	217822275	T	T	217822275	3	4	141	1	0	0	0	0	1	0	0	0	15068	11	1	5	126	5	SPATA17	1	217822275	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	1564148	217822275	31428346	44	25319											
TRIM67	440730	broad.mit.edu	37	chr1	231335944	231335944	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaagctgcgtcagtccacCggactgatggagtactgcct	8	10	12	11	2	1	2	1	2	0	0	2	4	2	4	3	2	4	2	3	2	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:231335944C>T	uc009xfn.1	+	4	1356	c.1314C>T	c.(1312-1314)ACC>ACT	p.T438T		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	438						cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GTCAGTCCACCGGACTGATGG	0.522													14	147					0	0	0	0	T	231335944	T	T	231335944	2	4	141	1	0	0	0	0	0	0	0	1	16607	639	23	1		1	TRIM67	1	231335944	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	13513669	231335944	17914677	45	25320											
RBM34	23029	broad.mit.edu	37	chr1	235324273	235324273	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actgaagagggacgccagccGaccggtgccacctctggaat	10	5	13	13	3	1	2	0	1	1	1	1	5	1	4	5	3	2	0	5	3	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:235324273G>A	uc001hwn.2	-	2	193	c.163C>T	c.(163-165)CGG>TGG	p.R55W	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Missense_Mutation_p.R55W	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	55						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			GACGCCAGCCGACCGGTGCCA	0.587													16	61					0	0	0	0	A	235324273	A	A	235324273	3	1	141	1	0	0	0	0	1	0	0	0	13196	1057	37	1	1190	1	RBM34	1	235324273	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3988329	235324273	13926348	46	25321											
RYR2	6262	broad.mit.edu	37	chr1	237774236	237774236	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacgccaaggctggttggtgCagtgtttggatcctctgcag	7	11	14	9	1	1	0	0	0	1	0	2	1	2	1	2	4	3	5	2	4	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:237774236C>A	uc001hyl.1	+	36	4978	c.4858C>A	c.(4858-4860)CAG>AAG	p.Q1620K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1620	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGGTTGGTGCAGTGTTTGGA	0.502													5	14					2.0095e-06	2.2488e-06	1	0	A	237774236	A	A	237774236	3	1	141	1	0	0	0	0	1	0	0	0	13834	711	25	4	5000	4	RYR2	1	237774236	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2449963	237774236	11476385	47	25322											
RYR2	6262	broad.mit.edu	37	chr1	237817705	237817705	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggcatttttgatgccctGtctcaaaaggtaatttaatg	10	15	10	6	0	1	1	1	1	1	0	2	1	1	1	1	3	1	2	1	3	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:237817705G>T	uc001hyl.1	+	52	8076	c.7956G>T	c.(7954-7956)CTG>CTT	p.L2652L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2652	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTGATGCCCTGTCTCAAAAGG	0.378													11	24					2.80697e-09	3.34012e-09	1	0	T	237817705	T	T	237817705	2	4	141	1	0	0	0	0	0	0	0	1	13834	1364	48	4		4	RYR2	1	237817705	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	43469	237817705	11432916	48	25323											
RYR2	6262	broad.mit.edu	37	chr1	237843850	237843850	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgctctggaggacatgcttCcaacaaagagaaagaaatgg	15	7	11	8	0	1	2	0	0	1	2	2	5	2	4	1	3	3	2	1	3	4	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:237843850C>G	uc001hyl.1	+	62	9110	c.8990C>G	c.(8989-8991)TCC>TGC	p.S2997C	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2997	Modulator (Potential).|Cytoplasmic (By similarity).|Calmodulin-binding (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGACATGCTTCCAACAAAGAG	0.388													9	8					0	0	0	0	G	237843850	G	G	237843850	3	3	141	1	0	0	0	0	1	0	0	0	13834	855	30	2	9236	2	RYR2	1	237843850	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	26145	237843850	11406771	49	25324											
FMN2	56776	broad.mit.edu	37	chr1	240370334	240370334	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatcataggattttagaggCgaaatcgatacagacttccc	13	10	9	9	2	1	2	1	0	0	2	3	5	2	3	1	2	1	1	1	2	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:240370334C>T	uc010pyd.1	+	5	2447	c.2222C>T	c.(2221-2223)GCG>GTG	p.A741V	FMN2_uc010pye.1_Missense_Mutation_p.A745V	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	741					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ATTTTAGAGGCGAAATCGATA	0.567													10	27					0	0	0	0	T	240370334	T	T	240370334	3	4	141	1	0	0	0	0	1	0	0	0	5982	768	27	1	2240	1	FMN2	1	240370334	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2526484	240370334	8880287	50	25325											
CHML	1122	broad.mit.edu	37	chr1	241798273	241798273	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttccttcccgaaatgcaaGaatcctagtgacatttttaa	12	14	5	10	1	0	2	0	1	0	1	3	3	3	2	3	0	1	1	3	0	5	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:241798273G>C	uc001hzd.2	-	1	960	c.796C>G	c.(796-798)CTT>GTT	p.L266V	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	266					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CGAAATGCAAGAATCCTAGTG	0.358													19	36					0	0	0	0	C	241798273	C	C	241798273	3	2	141	1	0	0	0	0	1	0	0	0	3366	942	33	2	1178	2	CHML	1	241798273	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1427939	241798273	7452348	51	25326											
CNST	163882	broad.mit.edu	37	chr1	246784843	246784844	+	Frame_Shift_Ins	INS	-	GC	GC																															atgctaatgagcagccagagINSgcgccaaagcttgttctgca																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:246784843_246784844insGC	uc001ibp.2	+	3	870_871	c.492_493insGC	c.(490-495)GAGGCGfs	p.E164fs	CNST_uc001ibo.3_Frame_Shift_Ins_p.E164fs	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	164_165					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						AGCAGCCAGAGGCGCCAAAGCT	0.441													---	---	---								GC	246784844	GC	GC	246784843	7	5	141	1	0	1	1	0	0	0	0	0	3649	991	35	0	498	0	CNST	1	246784843	Frame_Shift_Ins	INS	-	TCGA-CR-7370-01A-11D-2129-08	4986570	246784843	2465778	52	25327											
OR2G3	81469	broad.mit.edu	37	chr1	247769784	247769784	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaacaaggatatgaaagaGgctctgaggaaacttctctc	15	8	11	7	0	2	3	0	2	2	1	4	6	2	6	0	4	2	1	0	4	5	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:247769784G>C	uc010pyz.1	+	1	897	c.897G>C	c.(895-897)GAG>GAC	p.E299D		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATATGAAAGAGGCTCTGAGGA	0.408													39	76					0	0	0	0	C	247769784	C	C	247769784	3	2	141	1	0	0	0	0	1	0	0	0	11053	991	35	4	899	4	OR2G3	1	247769784	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	984941	247769784	1480837	53	25328											
OR2L3	391192	broad.mit.edu	37	chr1	248224349	248224349	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctatggcctatgatcgttaCattgctatttgctttcctct	6	19	6	10	1	2	1	0	1	2	0	4	1	3	1	2	1	3	3	2	1	4	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:248224349C>T	uc001idx.1	+	1	366	c.366C>T	c.(364-366)TAC>TAT	p.Y122Y	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ATGATCGTTACATTGCTATTT	0.448													100	141					0	0	0	0	T	248224349	T	T	248224349	2	4	141	1	0	0	0	0	0	0	0	1	11062	489	17	4		4	OR2L3	1	248224349	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	454565	248224349	1026272	54	25329											
OR2M2	391194	broad.mit.edu	37	chr1	248343675	248343675	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atattgctatttgccaccctCtaagatataccaatctcatg	12	14	4	11	0	2	1	1	0	2	1	3	1	2	1	3	0	3	1	3	0	6	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:248343675C>A	uc010pzf.1	+	1	388	c.388C>A	c.(388-390)CTA>ATA	p.L130I		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTGCCACCCTCTAAGATATAC	0.403													133	263					1.14977e-51	1.82026e-51	1	0	A	248343675	A	A	248343675	3	1	141	1	0	0	0	0	1	0	0	0	11064	912	32	2	390	2	OR2M2	1	248343675	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	119326	248343675	906946	55	25330											
OR2T12	127064	broad.mit.edu	37	chr1	248458101	248458101	+	Frame_Shift_Del	DEL	G	-	-																															ttagtggacctgtgggatttGggtctcatataggtaaaaat																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:248458101delG	uc010pzj.1	-	1	780	c.780delC	c.(778-780)CCCfs	p.P260fs		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TGTGGGATTTGGGTCTCATAT	0.483													---	---	---								-	248458101	-	-	248458101	7	5	141	1	0	1	0	1	0	0	0	0	11073	1335	47	0	185	0	OR2T12	1	248458101	Frame_Shift_Del	DEL	G	TCGA-CR-7370-01A-11D-2129-08	114426	248458101	792520	56	25331											
OR2M7	391196	broad.mit.edu	37	chr1	248487047	248487047	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacgatggtgtagaatacaGacaccatcttgtcctgcata	12	11	9	9	1	1	3	0	1	1	2	2	4	2	3	2	1	2	2	2	1	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:248487047G>A	uc010pzk.1	-	1	824	c.824C>T	c.(823-825)TCT>TTT	p.S275F		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTAGAATACAGACACCATCTT	0.463													43	64					0	0	0	0	A	248487047	A	A	248487047	3	1	141	1	0	0	0	0	1	0	0	0	11068	942	33	2	117	2	OR2M7	1	248487047	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	28946	248487047	763574	57	25332											
OR2T10	127069	broad.mit.edu	37	chr1	248756557	248756557	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagaagtgctgaatctcatgGgatctgcagaaggggaagct	13	8	14	6	0	2	3	1	1	2	2	3	5	2	5	0	3	3	3	0	3	5	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:248756557G>A	uc010pzn.1	-	1	513	c.513C>T	c.(511-513)TCC>TCT	p.S171S		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAATCTCATGGGATCTGCAGA	0.502													49	94					0	0	0	0	A	248756557	A	A	248756557	2	1	141	1	0	0	0	0	0	0	0	1	11071	1219	43	4		4	OR2T10	1	248756557	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	269510	248756557	494064	58	25333											
PXDN	7837	broad.mit.edu	37	chr2	1652098	1652098	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgatggccgccaggtccaGagccaccgtgtgtgccatgg	6	8	15	12	2	0	2	0	1	0	1	1	2	1	2	6	3	2	1	6	3	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:1652098G>T	uc002qxa.2	-	17	3518	c.3454C>A	c.(3454-3456)CTG>ATG	p.L1152M		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1152					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GCCAGGTCCAGAGCCACCGTG	0.647													24	42					1.37878e-21	1.96624e-21	1	0	T	1652098	T	T	1652098	3	4	141	1	0	0	0	0	1	0	0	0	12912	933	33	2	1013	2	PXDN	2	1652098	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08		1652098	241547275	59	25334											
PXDN	7837	broad.mit.edu	37	chr2	1652817	1652817	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcccgtacacgttggatGcgtctatgtaggaggtgagc	7	11	14	9	3	1	1	0	1	1	0	2	3	2	3	1	3	4	4	1	3	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:1652817G>A	uc002qxa.2	-	17	2799	c.2735C>T	c.(2734-2736)GCA>GTA	p.A912V		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	912					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CACGTTGGATGCGTCTATGTA	0.672													18	22					0	0	0	0	A	1652817	A	A	1652817	3	1	141	1	0	0	0	0	1	0	0	0	12912	1319	46	4	1732	4	PXDN	2	1652817	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	719	1652817	241546556	60	25335											
PXDN	7837	broad.mit.edu	37	chr2	1668820	1668820	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaataacgactctgtcctGaggcgtcacagtgaactgag	11	9	10	11	2	3	3	2	3	1	0	4	4	4	3	1	1	2	0	1	1	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:1668820G>C	uc002qxa.2	-	11	1382	c.1318C>G	c.(1318-1320)CAG>GAG	p.Q440E	PXDN_uc002qxb.1_Missense_Mutation_p.Q440E|PXDN_uc002qxc.1_Missense_Mutation_p.Q257E	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	440	Ig-like C2-type 3.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ACTCTGTCCTGAGGCGTCACA	0.532													9	8					0	0	0	0	C	1668820	C	C	1668820	3	2	141	1	0	0	0	0	1	0	0	0	12912	1299	45	2	3173	2	PXDN	2	1668820	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	16003	1668820	241530553	61	25336											
HPCAL1	3241	broad.mit.edu	37	chr2	10563138	10563138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagatggtgtcgtctgtgatGaagatgccggaggatgagtc	10	10	16	5	2	1	5	0	3	1	2	3	7	1	7	1	3	1	0	1	3	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:10563138G>A	uc002raj.2	+	4	782	c.408G>A	c.(406-408)ATG>ATA	p.M136I	HPCAL1_uc002rak.2_Missense_Mutation_p.M136I|HPCAL1_uc002ral.2_Missense_Mutation_p.M136I|HPCAL1_uc010exe.2_RNA|HPCAL1_uc010exf.2_Missense_Mutation_p.M136I	NM_002149	NP_002140	P37235	HPCL1_HUMAN	hippocalcin-like 1	136							calcium ion binding			pancreas(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)		CGTCTGTGATGAAGATGCCGG	0.622													11	36					0	0	0	0	A	10563138	A	A	10563138	3	1	141	1	0	0	0	0	1	0	0	0	7369	1290	45	2	414	2	HPCAL1	2	10563138	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	8894318	10563138	232636235	62	25337											
NBAS	51594	broad.mit.edu	37	chr2	15415825	15415825	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggaaagcatctgtccatccTtttcagggattttgggaaca	10	12	11	8	0	2	0	1	0	1	0	4	3	4	3	2	3	2	1	2	3	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:15415825T>A	uc002rcc.1	-	44	5533	c.5507A>T	c.(5506-5508)AAG>ATG	p.K1836M	NBAS_uc010exl.1_Missense_Mutation_p.K908M|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1836										ovary(2)|liver(1)|skin(1)	4						CTGTCCATCCTTTTCAGGGAT	0.433													17	54					0	0	0	0	A	15415825	A	A	15415825	3	1	141	1	0	0	0	0	1	0	0	0	10239	1609	56	5	1644	5	NBAS	2	15415825	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	4852687	15415825	227783548	63	25338											
DNMT3A	1788	broad.mit.edu	37	chr2	25464448	25464448	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacatgcttctgtgtgacgcTgcggacgtccccgacgtaca	7	10	11	13	5	1	1	0	1	1	0	2	3	2	2	2	1	4	3	2	1	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:25464448T>A	uc002rgc.2	-	17	2322	c.2065A>T	c.(2065-2067)AGC>TGC	p.S689C	DNMT3A_uc002rgd.2_Missense_Mutation_p.S689C|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.S500C	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	689					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTGTGACGCTGCGGACGTCC	0.612			Mis|F|N|S		AML								9	43					0	0	0	0	A	25464448	A	A	25464448	3	1	141	1	0	0	0	0	1	0	0	0	4698	1580	55	5	701	5	DNMT3A	2	25464448	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	10048623	25464448	217734925	64	25339											
TRMT61B	55006	broad.mit.edu	37	chr2	29074027	29074027	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgttgattttagattctactTtttgagctaaaattccattt	10	21	5	5	0	1	3	0	2	1	1	2	3	2	3	1	0	2	2	1	0	4	10			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:29074027T>C	uc002rmm.2	-	5	1255	c.1223A>G	c.(1222-1224)AAA>AGA	p.K408R	TRMT61B_uc002rmn.2_Missense_Mutation_p.K408R|TRMT61B_uc010ezk.2_Intron	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	408							tRNA (adenine-N1-)-methyltransferase activity				0						AGATTCTACTTTTTGAGCTAA	0.378													7	39					0	0	0	0	C	29074027	C	C	29074027	3	2	141	1	0	0	0	0	1	0	0	0	16637	1841	64	5	222	5	TRMT61B	2	29074027	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	3609579	29074027	214125346	65	25340											
TTC27	55622	broad.mit.edu	37	chr2	32859031	32859031	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccctgttgacttacaccctCaggactttttgtcatctgtt	6	16	6	13	0	3	1	2	1	1	0	3	2	3	2	3	1	1	2	3	1	1	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:32859031C>G	uc002rom.2	+	3	586	c.355C>G	c.(355-357)CAG>GAG	p.Q119E	TTC27_uc010ymx.1_Missense_Mutation_p.Q69E	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	119							protein binding			central_nervous_system(1)	1						CTTACACCCTCAGGACTTTTT	0.358													23	64					0	0	0	0	G	32859031	G	G	32859031	3	3	141	1	0	0	0	0	1	0	0	0	16763	827	29	2	365	2	TTC27	2	32859031	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3785004	32859031	210340342	66	25341											
LTBP1	4052	broad.mit.edu	37	chr2	33246136	33246136	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctggggctgcttcctcgtgGggccctcctgagcaagcagc	4	8	14	15	1	0	1	0	1	0	0	3	1	2	1	4	4	4	4	4	4	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:33246136G>T	uc002ros.2	+	3	726	c.726G>T	c.(724-726)TGG>TGT	p.W242C		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	242					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CTTCCTCGTGGGGCCCTCCTG	0.562													65	83					6.1719e-39	9.56449e-39	1	0	T	33246136	T	T	33246136	3	4	141	1	0	0	0	0	1	0	0	0	9123	1241	43	4	736	4	LTBP1	2	33246136	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	387105	33246136	209953237	67	25342											
C2orf86	51057	broad.mit.edu	37	chr2	63380060	63380060	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgttttacctgttctctgcCgtcttctctcagttctccgt	2	19	7	13	2	5	0	1	0	4	0	8	0	5	0	3	0	2	3	3	0	1	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:63380060C>A	uc002sch.2	-	17	2625	c.2179G>T	c.(2179-2181)GGC>TGC	p.G727C	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.G568C|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.G535C	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	727					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						TGTTCTCTGCCGTCTTCTCTC	0.274													10	29					1.05317e-09	1.26761e-09	1	0	A	63380060	A	A	63380060	3	1	141	1	0	0	0	0	1	0	0	0	2211	652	23	3	69	3	C2orf86	2	63380060	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	30133924	63380060	179819313	68	25343											
SPRED2	200734	broad.mit.edu	37	chr2	65540979	65540979	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtacacgcaccgcgagcgctCtccgtcctccttccgccgcc	4	7	9	21	7	1	0	0	0	1	0	5	1	4	0	7	0	2	3	7	0	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:65540979C>G	uc002sdr.3	-	6	1448	c.913G>C	c.(913-915)GAG>CAG	p.E305Q	SPRED2_uc010fcw.2_Missense_Mutation_p.E302Q	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	305					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CGCGAGCGCTCTCCGTCCTCC	0.682													20	94					0	0	0	0	G	65540979	G	G	65540979	3	3	141	1	0	0	0	0	1	0	0	0	15159	922	32	2	347	2	SPRED2	2	65540979	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2160919	65540979	177658394	69	25344											
SMYD5	10322	broad.mit.edu	37	chr2	73446061	73446061	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagaacggcccctggtggctGcacagtttctctggaatgca	8	10	12	11	1	1	1	0	0	1	1	2	2	1	2	2	4	3	4	2	4	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:73446061G>T	uc002siw.2	+	2	198	c.169G>T	c.(169-171)GCA>TCA	p.A57S	SMYD5_uc010yre.1_5'UTR	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	57							metal ion binding				0						CCTGGTGGCTGCACAGTTTCT	0.557													17	44					2.37509e-13	3.07044e-13	1	0	T	73446061	T	T	73446061	3	4	141	1	0	0	0	0	1	0	0	0	14889	1319	46	4	175	4	SMYD5	2	73446061	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	7905082	73446061	169753312	70	25345											
LOXL3	84695	broad.mit.edu	37	chr2	74763195	74763195	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgtgaacaatcctcagcTgtgatgttcttgtgggggca	8	13	12	8	0	2	2	1	2	1	0	3	2	3	2	1	2	2	3	1	2	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:74763195T>A	uc002smp.1	-	7	1248	c.1176A>T	c.(1174-1176)ACA>ACT	p.T392T	LOXL3_uc002smo.1_Silent_p.T31T|LOXL3_uc010ffm.1_Silent_p.T392T|LOXL3_uc002smq.1_Silent_p.T247T|LOXL3_uc010ffn.1_Silent_p.T247T	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	392	SRCR 3.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						AATCCTCAGCTGTGATGTTCT	0.567													39	46					0	0	0	0	A	74763195	A	A	74763195	2	1	141	1	0	0	0	0	0	0	0	1	8951	1567	55	5		5	LOXL3	2	74763195	Silent	SNP	T	TCGA-CR-7370-01A-11D-2129-08	1317134	74763195	168436178	71	25346											
REG1A	5967	broad.mit.edu	37	chr2	79349979	79349979	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatctagaaccgccgctggCactggagcagtgggtccctg	7	7	13	14	2	1	1	0	0	1	1	2	2	2	2	4	3	2	3	4	3	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:79349979C>T	uc002snz.2	+	5	437	c.334C>T	c.(334-336)CAC>TAC	p.H112Y	REG1A_uc010ysd.1_Missense_Mutation_p.H112Y	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	112	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CCGCCGCTGGCACTGGAGCAG	0.557													34	120					0	0	0	0	T	79349979	T	T	79349979	3	4	141	1	0	0	0	0	1	0	0	0	13275	710	25	4	348	4	REG1A	2	79349979	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4586784	79349979	163849394	72	25347											
PROM2	150696	broad.mit.edu	37	chr2	95952298	95952298	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccttcaccaggagaaggtCgtcccccagcagagccttgt	10	7	10	14	1	1	2	1	0	0	2	3	3	2	2	5	2	3	1	5	2	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:95952298C>A	uc002suh.1	+	17	2152	c.2019C>A	c.(2017-2019)GTC>GTA	p.V673V	PROM2_uc002sui.2_Silent_p.V673V|PROM2_uc002suj.2_Silent_p.V327V|PROM2_uc002suk.2_Silent_p.V673V|PROM2_uc002sul.2_Silent_p.V199V|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	673	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						AGGAGAAGGTCGTCCCCCAGC	0.612													34	44					2.87052e-16	3.85365e-16	1	0	A	95952298	A	A	95952298	2	1	141	1	0	0	0	0	0	0	0	1	12618	871	31	3		3	PROM2	2	95952298	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	16602319	95952298	147247075	73	25348											
AFF3	3899	broad.mit.edu	37	chr2	100623731	100623731	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagtgctacagatagacgaGggctggttctgggctcttga	8	11	15	7	1	2	3	0	1	2	2	2	4	2	3	0	3	2	5	0	3	3	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:100623731G>A	uc002tag.2	-	5	602	c.366C>T	c.(364-366)CCC>CCT	p.P122P	AFF3_uc002taf.2_Silent_p.P147P|AFF3_uc010fiq.1_Silent_p.P122P|AFF3_uc010yvr.1_Silent_p.P276P|AFF3_uc002tah.1_Silent_p.P147P|AFF3_uc010fir.1_Silent_p.P199P|AFF3_uc002tai.2_Silent_p.P44P	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	122					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						AGATAGACGAGGGCTGGTTCT	0.537													41	58					0	0	0	0	A	100623731	A	A	100623731	2	1	141	1	0	0	0	0	0	0	0	1	358	987	35	4		4	AFF3	2	100623731	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4671433	100623731	142575642	74	25349											
CCDC138	165055	broad.mit.edu	37	chr2	109408221	109408221	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gattatagagttagtacctcGaaaataaccaagcagtcttt	15	12	7	7	1	1	1	0	0	1	1	2	3	1	1	2	0	3	3	2	0	8	6	rs36034137	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:109408221G>A	uc002ten.1	+	4	417	c.357G>A	c.(355-357)TCG>TCA	p.S119S	CCDC138_uc002teo.1_Silent_p.S119S|CCDC138_uc002tep.1_5'UTR|CCDC138_uc010fjm.1_5'UTR	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	119											0						TTAGTACCTCGAAAATAACCA	0.284													18	101					0	0	0	0	A	109408221	A	A	109408221	2	1	141	1	0	0	0	0	0	0	0	1	2784	1045	37	1		1	CCDC138	2	109408221	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	8784490	109408221	133791152	75	25350											
DPP10	57628	broad.mit.edu	37	chr2	116598360	116598360	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacactcagcagaattaatCaagcacctaataaaagctgg	18	7	6	10	0	2	1	2	0	0	1	2	1	2	1	1	1	4	3	1	1	7	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:116598360C>G	uc002tla.1	+	25	2674	c.2217C>G	c.(2215-2217)ATC>ATG	p.I739M	DPP10_uc002tlb.1_Missense_Mutation_p.I689M|DPP10_uc002tlc.1_Missense_Mutation_p.I735M|DPP10_uc002tle.2_Missense_Mutation_p.I743M|DPP10_uc002tlf.1_Missense_Mutation_p.I732M	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	739	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CAGAATTAATCAAGCACCTAA	0.343													37	52					0	0	0	0	G	116598360	G	G	116598360	3	3	141	1	0	0	0	0	1	0	0	0	4749	816	29	2	2486	2	DPP10	2	116598360	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	7190139	116598360	126601013	76	25351											
GLI2	2736	broad.mit.edu	37	chr2	121555035	121555035	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcagcagcagcggtagctGcccaaggaggtactttctgt	8	8	14	11	2	1	0	0	0	1	0	1	1	1	1	1	4	6	6	1	4	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:121555035G>A	uc010flp.2	+	1	169	c.139G>A	c.(139-141)GCC>ACC	p.A47T	GLI2_uc010yyu.1_Missense_Mutation_p.A47T|GLI2_uc002tmp.1_Missense_Mutation_p.A47T|GLI2_uc010fln.1_RNA|GLI2_uc002tmq.1_5'UTR|GLI2_uc002tmr.1_5'UTR|GLI2_uc002tmt.3_5'UTR|GLI2_uc002tmu.3_5'UTR|GLI2_uc002tmv.1_Missense_Mutation_p.A47T|GLI2_uc010flo.1_5'UTR|GLI2_uc002tmw.1_Missense_Mutation_p.A47T	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	47					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				AGCGGTAGCTGCCCAAGGAGG	0.572													29	66					0	0	0	0	A	121555035	A	A	121555035	3	1	141	1	0	0	0	0	1	0	0	0	6475	1319	46	4	141	4	GLI2	2	121555035	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4956675	121555035	121644338	77	25352											
YSK4	80122	broad.mit.edu	37	chr2	135744037	135744037	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggataaatctgagacaggaGggaattcattctgtttcatg	12	13	11	5	0	4	1	2	1	2	1	4	5	4	4	0	3	0	1	0	3	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:135744037G>A	uc002tue.1	-	7	2436	c.2405C>T	c.(2404-2406)CCT>CTT	p.P802L	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.P689L|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.P530L|YSK4_uc002tui.3_Missense_Mutation_p.P819L	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	802							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TGAGACAGGAGGGAATTCATT	0.388													54	56					0	0	0	0	A	135744037	A	A	135744037	3	1	141	1	0	0	0	0	1	0	0	0	17563	1000	35	4	1597	4	YSK4	2	135744037	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	14189002	135744037	107455336	78	25353											
R3HDM1	23518	broad.mit.edu	37	chr2	136467633	136467633	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattctgattttcagctggAccaccaccgccacctggtgg	9	10	9	13	1	2	1	1	1	1	0	2	2	2	2	5	3	1	1	5	3	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:136467633A>G	uc002tuo.2	+	22	2833	c.2463A>G	c.(2461-2463)GGA>GGG	p.G821G	R3HDM1_uc010fni.2_Silent_p.G820G|R3HDM1_uc002tup.2_Silent_p.G766G|R3HDM1_uc010zbh.1_Silent_p.G569G	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	821							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		TTTCAGCTGGACCACCACCGC	0.443											OREG0014997	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	73					0	0	0	0	G	136467633	G	G	136467633	2	3	141	1	0	0	0	0	0	0	0	1	12952	262	10	5		5	R3HDM1	2	136467633	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	723596	136467633	106731740	79	25354											
LCT	3938	broad.mit.edu	37	chr2	136566979	136566979	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgggaaaatccgagaccAggagatagagaagcggtagg	15	5	16	5	2	0	3	0	0	0	3	1	7	1	4	2	4	1	2	2	4	5	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:136566979A>T	uc002tuu.1	-	8	2949	c.2938T>A	c.(2938-2940)TGG>AGG	p.W980R		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	980	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATCCGAGACCAGGAGATAGAG	0.498													40	50					0	0	0	0	T	136566979	T	T	136566979	3	4	141	1	0	0	0	0	1	0	0	0	8733	188	7	5	2885	5	LCT	2	136566979	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	99346	136566979	106632394	80	25355											
UPP2	151531	broad.mit.edu	37	chr2	158962720	158962720	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctaccagcaatgtttggaGatgtaaaggtaaaaacattt	16	11	8	6	0	0	1	0	0	0	1	0	2	0	1	2	2	3	4	2	2	7	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:158962720G>C	uc002tzp.2	+	2	366	c.172G>C	c.(172-174)GAT>CAT	p.D58H	UPP2_uc002tzo.2_Missense_Mutation_p.D115H	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	58					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						AATGTTTGGAGATGTAAAGGT	0.328													15	27					0	0	0	0	C	158962720	C	C	158962720	3	2	141	1	0	0	0	0	1	0	0	0	17081	942	33	2	357	2	UPP2	2	158962720	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	22395741	158962720	84236653	81	25356											
BAZ2B	29994	broad.mit.edu	37	chr2	160257124	160257124	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctacctctagaatttgctGagctcgaagttctttttcca	8	17	6	10	1	3	2	0	1	3	1	5	3	4	2	2	0	3	3	2	0	4	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:160257124G>A	uc002uao.2	-	17	3236	c.2884C>T	c.(2884-2886)CAG>TAG	p.Q962*	BAZ2B_uc002uap.2_Nonsense_Mutation_p.Q926*|BAZ2B_uc002uaq.1_Nonsense_Mutation_p.Q792*	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	962	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AGAATTTGCTGAGCTCGAAGT	0.259													11	26					0	0	0	0	A	160257124	A	A	160257124	4	1	141	1	0	0	0	0	0	1	0	0	1334	1299	45	2	3706	2	BAZ2B	2	160257124	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1294404	160257124	82942249	82	25357											
FIGN	55137	broad.mit.edu	37	chr2	164466811	164466811	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgtcagtccactgaacgCgtctgacctcaacactggcc	8	7	10	16	3	3	2	2	2	1	0	4	2	4	2	4	2	2	0	4	2	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:164466811C>A	uc002uck.1	-	3	1842	c.1531G>T	c.(1531-1533)GCG>TCG	p.A511S		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	511						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CCACTGAACGCGTCTGACCTC	0.532													54	60					9.10829e-22	1.30909e-21	1	0	A	164466811	A	A	164466811	3	1	141	1	0	0	0	0	1	0	0	0	5923	768	27	3	752	3	FIGN	2	164466811	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4209687	164466811	78732562	83	25358											
SCN3A	6328	broad.mit.edu	37	chr2	165956828	165956828	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccctcatgccttcaaacCgggataaggctcttagaggt	10	11	9	11	1	3	1	2	0	1	1	3	2	3	2	3	3	3	1	3	3	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:165956828C>A	uc002ucx.2	-	22	4442	c.3950G>T	c.(3949-3951)CGG>CTG	p.R1317L	SCN3A_uc002ucy.2_Missense_Mutation_p.R1268L|SCN3A_uc002ucz.2_Missense_Mutation_p.R1268L|SCN3A_uc002uda.1_Missense_Mutation_p.R1137L|SCN3A_uc002udb.1_Missense_Mutation_p.R1137L	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1317	Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GCCTTCAAACCGGGATAAGGC	0.403													39	56					6.33695e-27	9.49894e-27	1	0	A	165956828	A	A	165956828	3	1	141	1	0	0	0	0	1	0	0	0	13983	652	23	3	2080	3	SCN3A	2	165956828	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1490017	165956828	77242545	84	25359											
SCRN3	79634	broad.mit.edu	37	chr2	175287708	175287708	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccactgcaagcatggttTctattttacctcaagactcc	10	13	6	12	0	2	2	1	1	1	1	3	2	3	2	3	1	3	3	3	1	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:175287708T>A	uc002uiq.2	+	6	938	c.850T>A	c.(850-852)TCT>ACT	p.S284T	SCRN3_uc010zen.1_Missense_Mutation_p.S277T|SCRN3_uc010zeo.1_Missense_Mutation_p.S82T|SCRN3_uc002uis.2_Missense_Mutation_p.S26T	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	284					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			AAGCATGGTTTCTATTTTACC	0.408													42	46					0	0	0	0	A	175287708	A	A	175287708	3	1	141	1	0	0	0	0	1	0	0	0	14005	1783	62	5	868	5	SCRN3	2	175287708	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	9330880	175287708	67911665	85	25360											
TTN	7273	broad.mit.edu	37	chr2	179401131	179401131	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcactgaaaagacagtttctCgaatttcttctgttgtcaca	11	15	6	9	1	5	2	2	1	3	1	6	3	5	2	0	0	0	2	0	0	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179401131C>G	uc010zfg.1	-	306	92863	c.92639G>C	c.(92638-92640)CGA>CCA	p.R30880P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R24575P|TTN_uc010zfi.1_Missense_Mutation_p.R24508P|TTN_uc010zfj.1_Missense_Mutation_p.R24383P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31807							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACAGTTTCTCGAATTTCTTC	0.388													23	61					0	0	0	0	G	179401131	G	G	179401131	3	3	141	1	0	0	0	0	1	0	0	0	16803	884	31	3	7660	3	TTN	2	179401131	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4113423	179401131	63798242	86	25361											
TTN	7273	broad.mit.edu	37	chr2	179412806	179412806	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttggccttcacacggaattCatattcagttttctcaacaa	11	14	5	11	1	4	0	4	0	1	0	5	1	4	1	1	2	1	1	1	2	4	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179412806C>T	uc010zfg.1	-	288	86067	c.85843G>A	c.(85843-85845)GAA>AAA	p.E28615K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E22310K|TTN_uc010zfi.1_Missense_Mutation_p.E22243K|TTN_uc010zfj.1_Missense_Mutation_p.E22118K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29542							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACGGAATTCATATTCAGTT	0.453													93	88					0	0	0	0	T	179412806	T	T	179412806	3	4	141	1	0	0	0	0	1	0	0	0	16803	835	29	2	14528	2	TTN	2	179412806	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	11675	179412806	63786567	87	25362											
TTN	7273	broad.mit.edu	37	chr2	179439363	179439363	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtaactgcagttacctgaggGgtaccaggaggtccaggaac	11	7	14	9	0	0	1	0	1	0	0	1	3	1	3	3	5	5	4	3	5	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179439363G>T	uc010zfg.1	-	275	64016	c.63792C>A	c.(63790-63792)ACC>ACA	p.T21264T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T14959T|TTN_uc010zfi.1_Silent_p.T14892T|TTN_uc010zfj.1_Silent_p.T14767T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22191							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACCTGAGGGGTACCAGGAG	0.448													18	87					3.51602e-12	4.48216e-12	1	0	T	179439363	T	T	179439363	2	4	141	1	0	0	0	0	0	0	0	1	16803	1219	43	4		4	TTN	2	179439363	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	26557	179439363	63760010	88	25363											
TTN	7273	broad.mit.edu	37	chr2	179443986	179443986	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gactctagtgtcagttgctaGaggatcttcccctttcttcc	6	15	8	12	0	4	1	1	0	3	1	6	3	6	2	3	1	1	2	3	1	2	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179443986G>C	uc010zfg.1	-	269	60291	c.60067C>G	c.(60067-60069)CTA>GTA	p.L20023V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L13718V|TTN_uc010zfi.1_Missense_Mutation_p.L13651V|TTN_uc010zfj.1_Missense_Mutation_p.L13526V|uc002umv.1_Missense_Mutation_p.R71T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20950							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGTTGCTAGAGGATCTTCC	0.438													55	65					0	0	0	0	C	179443986	C	C	179443986	3	2	141	1	0	0	0	0	1	0	0	0	16803	933	33	2	40380	2	TTN	2	179443986	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4623	179443986	63755387	89	25364											
TTN	7273	broad.mit.edu	37	chr2	179598401	179598401	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcattttcagccaggcacgTgtatttgcctccaaaactaa	11	13	6	11	1	2	0	2	0	0	0	3	0	3	0	3	1	3	2	3	1	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179598401T>C	uc010zfg.1	-	50	12207	c.11983A>G	c.(11983-11985)ACG>GCG	p.T3995A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T656A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4922							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E3995*(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCAGGCACGTGTATTTGCCT	0.383													48	119					0	0	0	0	C	179598401	C	C	179598401	3	2	141	1	0	0	0	0	1	0	0	0	16803	1696	59	5	89054	5	TTN	2	179598401	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	154415	179598401	63600972	90	25365											
TTN	7273	broad.mit.edu	37	chr2	179610817	179610817	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacatttcgaattttaagaGtgtgacttcccttctcctcg	9	15	7	10	2	1	3	0	1	1	2	5	4	2	3	2	0	0	0	2	0	2	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179610817G>T	uc002unb.2	-	46	16534	c.16310C>A	c.(16309-16311)ACT>AAT	p.T5437N	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	8944							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTTTAAGAGTGTGACTTCC	0.418													96	101					5.71645e-57	9.0696e-57	1	0	T	179610817	T	T	179610817	3	4	141	1	0	0	0	0	1	0	0	0	16803	1029	36	4	93987	4	TTN	2	179610817	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	12416	179610817	63588556	91	25366											
TTN	7273	broad.mit.edu	37	chr2	179613353	179613353	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggttgaccactatctaattCttggaatttcacatctgtgt	9	17	7	8	0	4	1	1	1	3	0	4	2	4	2	1	2	0	1	1	2	3	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179613353C>T	uc002unb.2	-	46	13998	c.13774G>A	c.(13774-13776)GAA>AAA	p.E4592K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTATCTAATTCTTGGAATTTC	0.318													11	234					0	0	0	0	T	179613353	T	T	179613353	3	4	141	1	0	0	0	0	1	0	0	0	16803	922	32	2	96523	2	TTN	2	179613353	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2536	179613353	63586020	92	25367											
SSFA2	6744	broad.mit.edu	37	chr2	182779977	182779977	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaggctatggggagtagtgCtgatagttgtgacagtgaga	10	10	17	4	0	0	3	0	3	0	1	0	5	0	4	0	3	1	5	0	3	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:182779977C>T	uc002uoi.2	+	11	1932	c.1610C>T	c.(1609-1611)GCT>GTT	p.A537V	SSFA2_uc002uoh.2_Missense_Mutation_p.A537V|SSFA2_uc002uoj.2_Missense_Mutation_p.A537V|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.A384V|SSFA2_uc002uol.2_Missense_Mutation_p.A384V|SSFA2_uc002uom.2_Missense_Mutation_p.A5V	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	537						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			GGGAGTAGTGCTGATAGTTGT	0.423													66	82					0	0	0	0	T	182779977	T	T	182779977	3	4	141	1	0	0	0	0	1	0	0	0	15249	797	28	4	1652	4	SSFA2	2	182779977	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3166624	182779977	60419396	93	25368											
COL5A2	1290	broad.mit.edu	37	chr2	189918902	189918902	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taccttttctccagtaggacCtgccggacctggagggccca	7	9	11	14	1	1	0	0	0	1	0	2	3	1	3	6	4	2	1	6	4	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:189918902C>A	uc002uqk.2	-	36	2703	c.2428G>T	c.(2428-2430)GGT>TGT	p.G810C	COL5A2_uc010frx.2_Missense_Mutation_p.G386C	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	810					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAGTAGGACCTGCCGGACCT	0.393													55	71					3.63617e-18	4.9819e-18	1	0	A	189918902	A	A	189918902	3	1	141	1	0	0	0	0	1	0	0	0	3712	681	24	4	2147	4	COL5A2	2	189918902	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	7138925	189918902	53280471	94	25369											
DNAH7	56171	broad.mit.edu	37	chr2	196825030	196825030	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaaggagatcctcgcatagTttgtgttttaataatatggt	12	15	10	4	1	0	1	0	0	0	1	2	3	1	1	1	2	0	3	1	2	5	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:196825030T>C	uc002utj.3	-	18	2946	c.2845A>G	c.(2845-2847)ACT>GCT	p.T949A		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	949	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CCTCGCATAGTTTGTGTTTTA	0.323													11	157					0	0	0	0	C	196825030	C	C	196825030	3	2	141	1	0	0	0	0	1	0	0	0	4628	1725	60	5	9421	5	DNAH7	2	196825030	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	6906128	196825030	46374343	95	25370											
CYP27A1	1593	broad.mit.edu	37	chr2	219677074	219677074	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgactcgactggaccagctGcgggcagagagtgcttcggg	8	7	16	10	3	0	2	0	1	0	1	2	5	0	3	1	3	3	3	1	3	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:219677074G>T	uc002viz.3	+	3	1010	c.576G>T	c.(574-576)CTG>CTT	p.L192L		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	192					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	TGGACCAGCTGCGGGCAGAGA	0.557													11	173					1.08611e-07	1.24006e-07	1	0	T	219677074	T	T	219677074	2	4	141	1	0	0	0	0	0	0	0	1	4175	1306	46	4		4	CYP27A1	2	219677074	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	22852044	219677074	23522299	96	25371											
SP140L	93349	broad.mit.edu	37	chr2	231248247	231248247	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaaaagaaggggcatggctgGagcagaatgggaacgagaac	17	3	16	5	1	0	3	0	0	0	3	0	6	0	5	0	5	3	3	0	5	6	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:231248247G>T	uc010fxm.1	+	8	751	c.660G>T	c.(658-660)TGG>TGT	p.W220C	SP140L_uc010fxo.1_Missense_Mutation_p.W27C	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	220						nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1						GGCATGGCTGGAGCAGAATGG	0.358													8	15					2.17888e-05	2.3626e-05	1	0	T	231248247	T	T	231248247	3	4	141	1	0	0	0	0	1	0	0	0	15027	1183	41	2	690	2	SP140L	2	231248247	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	11571173	231248247	11951126	97	25372											
ECEL1	9427	broad.mit.edu	37	chr2	233349955	233349956	+	Missense_Mutation	DNP	AG	TT	TT																															ggtacagggtcctctctggcAgggtgagcccatcctggtca																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:233349955_233349956AG>TT	uc002vsv.2	-	3	1013_1014	c.808_809CT>AA	c.(808-810)CTG>AAG	p.L270K	ECEL1_uc010fya.1_Missense_Mutation_p.L270K|ECEL1_uc010fyb.1_5'UTR	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	270	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CCTCTCTGGCAGGGTGAGCCCA	0.634													15	5					0	0	0	0	TT	233349956	TT	TT	233349955	3	4	141	1	0	0	0	0	1	0	0	0	4913	188	7	5	1582	5	ECEL1	2	233349955	Missense_Mutation	DNP	AG	TCGA-CR-7370-01A-11D-2129-08	2101708	233349955	9849418	98	25373											
KIF1A	547	broad.mit.edu	37	chr2	241661290	241661290	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgttgaatgtgtgcgtgagCaggcgcaagcactgtggaca	9	9	15	8	2	0	2	0	2	0	0	0	3	0	3	0	2	3	4	0	2	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:241661290C>T	uc002vzy.2	-	42	4520	c.4374G>A	c.(4372-4374)CTG>CTA	p.L1458L	KIF1A_uc010fzk.2_Silent_p.L1559L|KIF1A_uc002vzw.2_Silent_p.L119L|KIF1A_uc002vzx.2_Silent_p.L185L	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1458					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TGTGCGTGAGCAGGCGCAAGC	0.657													6	2					0	0	0	0	T	241661290	T	T	241661290	2	4	141	1	0	0	0	0	0	0	0	1	8322	697	25	4		4	KIF1A	2	241661290	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	8311335	241661290	1538083	99	25374											
CNTN4	152330	broad.mit.edu	37	chr3	3081938	3081938	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagtcccaccacggtggTgtattctgcagaagaaggta	10	11	11	9	1	2	2	1	0	1	2	3	2	3	2	2	3	1	3	2	3	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:3081938T>G	uc003bpc.2	+	19	2602	c.2381T>G	c.(2380-2382)GTG>GGG	p.V794G	CNTN4_uc003bpb.1_Missense_Mutation_p.V465G|CNTN4_uc003bpe.2_Missense_Mutation_p.V466G|CNTN4_uc003bpf.2_Missense_Mutation_p.V465G|CNTN4_uc003bpg.2_Missense_Mutation_p.V50G	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	794	Fibronectin type-III 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ACCACGGTGGTGTATTCTGCA	0.428													25	17					0	0	0	0	G	3081938	G	G	3081938	3	3	141	1	0	0	0	0	1	0	0	0	3658	1696	59	5	2447	5	CNTN4	3	3081938	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08		3081938	194940492	100	25375											
CHCHD4	131474	broad.mit.edu	37	chr3	14154541	14154541	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatgcattcctgcatggccCggaactggtctacacagtct	8	10	10	13	1	2	0	0	0	2	0	3	1	3	1	2	3	4	3	2	3	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:14154541C>T	uc003byj.3	-	3	470	c.275G>A	c.(274-276)CGG>CAG	p.R92Q	CHCHD4_uc003byi.3_Missense_Mutation_p.R105Q	NM_001098502	NP_001091972	Q8N4Q1	MIA40_HUMAN	coiled-coil-helix-coiled-coil-helix domain	92	CHCH.				protein transport|transmembrane transport	mitochondrial intermembrane space					0						CTGCATGGCCCGGAACTGGTC	0.388													3	45					0	0	0	0	T	14154541	T	T	14154541	3	4	141	1	0	0	0	0	1	0	0	0	3333	652	23	1	157	1	CHCHD4	3	14154541	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	11072603	14154541	183867889	101	25376											
XPC	7508	broad.mit.edu	37	chr3	14220052	14220052	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgcggctccccgccggccGcgcgtttccgagccatgttg	2	7	13	19	8	0	0	0	0	0	0	2	1	2	0	7	2	1	3	7	2	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:14220052G>C	uc011ave.1	-	1	121	c.17C>G	c.(16-18)GCG>GGG	p.A6G	XPC_uc011avf.1_5'UTR|XPC_uc011avg.1_Missense_Mutation_p.A6G|LSM3_uc003byn.2_5'Flank	NM_004628	NP_004619	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	6					nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			ovary(2)|breast(1)	3						CCCGCCGGCCGCGCGTTTCCG	0.701			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				5	37					0	0	0	0	C	14220052	C	C	14220052	3	2	141	1	0	0	0	0	1	0	0	0	17509	1087	38	3	1818	3	XPC	3	14220052	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	65511	14220052	183802378	102	25377											
C3orf20	84077	broad.mit.edu	37	chr3	14745912	14745912	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcttacgaaactacaaggCaaagatgccctctcatctaa	15	9	6	11	1	3	1	1	0	3	1	4	3	3	1	1	1	4	1	1	1	6	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:14745912C>T	uc003byy.2	+	7	1351	c.947C>T	c.(946-948)GCA>GTA	p.A316V	C3orf20_uc003byz.2_Missense_Mutation_p.A194V|C3orf20_uc003bza.2_Missense_Mutation_p.A194V|C3orf20_uc003byx.1_Intron	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	316						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						AACTACAAGGCAAAGATGCCC	0.512													46	26					0	0	0	0	T	14745912	T	T	14745912	3	4	141	1	0	0	0	0	1	0	0	0	2223	710	25	4	965	4	C3orf20	3	14745912	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	525860	14745912	183276518	103	25378											
GALNTL2	117248	broad.mit.edu	37	chr3	16254215	16254215	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cattgctgagacctggctggGgtcattcaaagaaaccttct	10	11	10	10	0	3	2	2	1	1	2	3	3	3	2	2	3	2	2	2	3	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:16254215G>T	uc003car.3	+	6	1812	c.1337G>T	c.(1336-1338)GGG>GTG	p.G446V	GALNTL2_uc003caq.3_Missense_Mutation_p.G179V	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	446	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						ACCTGGCTGGGGTCATTCAAA	0.557													41	25					5.44703e-19	7.56188e-19	1	0	T	16254215	T	T	16254215	3	4	141	1	0	0	0	0	1	0	0	0	6257	1232	43	4	1359	4	GALNTL2	3	16254215	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1508303	16254215	181768215	104	25379											
ARPP21	10777	broad.mit.edu	37	chr3	35778754	35778754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctgcgaagcgccatggtggGgcagtcccaacagcagccac	9	4	13	15	2	0	0	0	0	0	0	1	1	1	0	4	3	5	2	4	3	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:35778754G>A	uc003cgb.2	+	16	1808	c.1544G>A	c.(1543-1545)GGG>GAG	p.G515E	ARPP21_uc003cga.2_Missense_Mutation_p.G461E|ARPP21_uc011axy.1_Missense_Mutation_p.G481E|ARPP21_uc003cgf.2_Missense_Mutation_p.G316E|ARPP21_uc003cgg.2_Missense_Mutation_p.G3E	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	515	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GCCATGGTGGGGCAGTCCCAA	0.627													30	27					0	0	0	0	A	35778754	A	A	35778754	3	1	141	1	0	0	0	0	1	0	0	0	980	1232	43	4	1611	4	ARPP21	3	35778754	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	19524539	35778754	162243676	105	25380											
SCN11A	11280	broad.mit.edu	37	chr3	38889201	38889201	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtcggagggaaaggaatgtGctcctgattttccaaggtag	10	10	14	7	2	0	1	0	1	0	0	3	4	2	4	2	4	1	2	2	4	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:38889201G>T	uc011ays.1	-	26	4559	c.4360C>A	c.(4360-4362)CAC>AAC	p.H1454N		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1454	IV.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAAGGAATGTGCTCCTGATTT	0.502													19	10					4.30721e-22	6.21493e-22	1	0	T	38889201	T	T	38889201	3	4	141	1	0	0	0	0	1	0	0	0	13978	1319	46	4	1019	4	SCN11A	3	38889201	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3110447	38889201	159133229	106	25381											
SCN11A	11280	broad.mit.edu	37	chr3	38951680	38951680	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttggtgtgcttacattcAtattgtatggaacaggcact	10	16	9	6	0	1	0	1	0	0	0	1	1	1	1	0	3	3	3	0	3	4	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:38951680A>T	uc011ays.1	-	8	1177	c.978T>A	c.(976-978)TAT>TAA	p.Y326*		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	326	I.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GCTTACATTCATATTGTATGG	0.383													44	17					0	0	0	0	T	38951680	T	T	38951680	4	4	141	1	0	0	0	0	0	1	0	0	13978	224	8	5	4473	5	SCN11A	3	38951680	Nonsense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	62479	38951680	159070750	107	25382											
CDCP1	64866	broad.mit.edu	37	chr3	45152275	45152275	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggaagccttctgggtagttGgcagacatcagggttgctga	8	10	16	7	0	2	2	1	1	1	1	2	3	2	3	1	4	2	5	1	4	2	4	rs151241354		TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:45152275G>T	uc003com.2	-	4	849	c.714C>A	c.(712-714)GCC>GCA	p.A238A	CDCP1_uc003con.2_Silent_p.A238A	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	238	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		CTGGGTAGTTGGCAGACATCA	0.542													10	139					1.58986e-06	1.78464e-06	1	0	T	45152275	T	T	45152275	2	4	141	1	0	0	0	0	0	0	0	1	3108	1335	47	4		4	CDCP1	3	45152275	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	6200595	45152275	152870155	108	25383											
DHX30	22907	broad.mit.edu	37	chr3	47890739	47890739	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttcctggtggggaagccctCggactgcaccctggcctccg	4	8	13	16	2	0	0	0	0	0	0	3	2	2	2	5	5	2	1	5	5	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:47890739C>T	uc003cru.2	+	19	3413	c.2987C>T	c.(2986-2988)TCG>TTG	p.S996L	DHX30_uc003crt.2_Missense_Mutation_p.S957L|MIR1226_hsa-mir-1226|MI0006313_5'Flank	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	996						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GGGAAGCCCTCGGACTGCACC	0.597													5	54					0	0	0	0	T	47890739	T	T	47890739	3	4	141	1	0	0	0	0	1	0	0	0	4526	893	31	1	3064	1	DHX30	3	47890739	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2738464	47890739	150131691	109	25384											
BSN	8927	broad.mit.edu	37	chr3	49690362	49690362	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacaccgctcctcctgctctGagtactcaccctcaccctcc	6	10	4	21	1	3	1	2	1	1	0	6	1	6	1	6	0	3	3	6	0	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:49690362G>C	uc003cxe.3	+	5	3487	c.3373G>C	c.(3373-3375)GAG>CAG	p.E1125Q		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1125					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTCCTGCTCTGAGTACTCACC	0.612													36	27					0	0	0	0	C	49690362	C	C	49690362	3	2	141	1	0	0	0	0	1	0	0	0	1535	1291	45	2	3391	2	BSN	3	49690362	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1799623	49690362	148332068	110	25385											
PARP3	10039	broad.mit.edu	37	chr3	51982442	51982442	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcccagagcgagtacctCatctaccaggagagccagtg	10	8	10	13	1	3	2	1	0	2	2	4	4	3	2	4	1	4	1	4	1	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:51982442C>T	uc003dby.2	+	11	1919	c.1548C>T	c.(1546-1548)CTC>CTT	p.L516L	PARP3_uc003dbz.2_Silent_p.L523L	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	516	PARP catalytic.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCGAGTACCTCATCTACCAGG	0.642													38	15					0	0	0	0	T	51982442	T	T	51982442	2	4	141	1	0	0	0	0	0	0	0	1	11516	813	29	2		2	PARP3	3	51982442	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2292080	51982442	146039988	111	25386											
SFMBT1	51460	broad.mit.edu	37	chr3	52945182	52945182	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaacagtagcccgataactCtttcctttatatctgccatt	10	15	4	12	1	3	0	1	0	2	0	4	1	4	0	3	0	4	1	3	0	5	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:52945182C>A	uc003dgf.2	-	18	2312	c.1743G>T	c.(1741-1743)AAG>AAT	p.K581N	SFMBT1_uc010hmr.2_Missense_Mutation_p.K528N|SFMBT1_uc003dgg.2_Missense_Mutation_p.K581N|SFMBT1_uc003dgh.2_Missense_Mutation_p.K581N	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	581					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		CCCGATAACTCTTTCCTTTAT	0.388													41	22					1.6237e-14	2.13292e-14	1	0	A	52945182	A	A	52945182	3	1	141	1	0	0	0	0	1	0	0	0	14222	912	32	2	877	2	SFMBT1	3	52945182	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	962740	52945182	145077248	112	25387											
COL8A1	1295	broad.mit.edu	37	chr3	99513341	99513341	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggaccacaaggacctcCagggcctcatggacttcctg	9	6	10	16	0	1	0	1	0	0	0	3	3	3	3	6	4	0	0	6	4	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:99513341C>A	uc003dtg.1	+	5	841	c.596C>A	c.(595-597)CCA>CAA	p.P199Q	COL8A1_uc003dth.1_Missense_Mutation_p.P199Q|COL8A1_uc003dti.1_Missense_Mutation_p.P200Q	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	199	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						CAAGGACCTCCAGGGCCTCAT	0.592													23	27					2.27731e-05	2.46204e-05	1	0	A	99513341	A	A	99513341	3	1	141	1	0	0	0	0	1	0	0	0	3720	594	21	4	602	4	COL8A1	3	99513341	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	46568159	99513341	98509089	113	25388											
ABI3BP	25890	broad.mit.edu	37	chr3	100621495	100621495	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttttgacttggaggtggagCaggtcgcacaactatcagat	10	11	12	8	1	1	2	1	1	0	1	2	4	1	4	0	4	2	2	0	4	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:100621495C>A	uc003dun.2	-	3	401	c.316G>T	c.(316-318)GCT>TCT	p.A106S	ABI3BP_uc003duo.2_Missense_Mutation_p.A99S|ABI3BP_uc003dup.3_Missense_Mutation_p.A99S	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	106						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						GGAGGTGGAGCAGGTCGCACA	0.398													17	27					2.70639e-06	3.01487e-06	1	0	A	100621495	A	A	100621495	3	1	141	1	0	0	0	0	1	0	0	0	91	710	25	4	3043	4	ABI3BP	3	100621495	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1108154	100621495	97400935	114	25389											
WDR52	55779	broad.mit.edu	37	chr3	113099870	113099870	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaagtggagcttcaagaataTagccattttcacagataatt	15	12	8	6	0	2	2	2	0	0	2	2	4	2	3	1	1	2	1	1	1	6	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:113099870T>C	uc003eae.1	-	16	1974	c.1928A>G	c.(1927-1929)TAT>TGT	p.Y643C		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	643										central_nervous_system(1)	1						TTCAAGAATATAGCCATTTTC	0.299													30	47					0	0	0	0	C	113099870	C	C	113099870	3	2	141	1	0	0	0	0	1	0	0	0	17372	1406	49	5	3731	5	WDR52	3	113099870	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	12478375	113099870	84922560	115	25390											
HCLS1	3059	broad.mit.edu	37	chr3	121352001	121352001	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gactctgatgatggaggagtCccaactggaggccaggcctg	9	7	15	10	0	1	2	0	2	1	0	2	6	2	5	3	5	1	0	3	5	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:121352001C>A	uc003eeh.3	-	11	1046	c.921G>T	c.(919-921)GGG>GGT	p.G307G	HCLS1_uc011bjj.1_Silent_p.G270G|HCLS1_uc011bjk.1_RNA	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	307					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		ATGGAGGAGTCCCAACTGGAG	0.468													8	5					0.00307968	0.00320654	1	0	A	121352001	A	A	121352001	2	1	141	1	0	0	0	0	0	0	0	1	7034	842	30	2		2	HCLS1	3	121352001	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	8252131	121352001	76670429	116	25391											
PARP9	83666	broad.mit.edu	37	chr3	122277281	122277281	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagagcgaggtaatcctacCtgatttttcattgtaagctg	10	14	10	7	1	1	2	1	2	0	1	2	4	2	2	2	1	3	3	2	1	3	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:122277281C>A	uc010hri.2	-	3	194	c.49G>T	c.(49-51)GGT>TGT	p.G17C	PARP9_uc003eff.3_Nonsense_Mutation_p.E17*|PARP9_uc011bjs.1_Nonsense_Mutation_p.E17*|PARP9_uc003efg.2_Missense_Mutation_p.D17Y|PARP9_uc003efi.2_Nonsense_Mutation_p.E17*|PARP9_uc003efh.2_Missense_Mutation_p.G17C|PARP9_uc003efj.2_Nonsense_Mutation_p.E17*	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	17					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		GTAATCCTACCTGATTTTTCA	0.423													40	42					1.07121e-22	1.55793e-22	1	0	A	122277281	A	A	122277281	3	1	141	1	0	0	0	0	1	0	0	0	11520	695	24	4	2604	4	PARP9	3	122277281	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	925280	122277281	75745149	117	25392											
KIAA1257	57501	broad.mit.edu	37	chr3	128695838	128695838	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttactgaatcgtggaagaatCgtccattttgagggacttct	10	14	10	7	2	1	3	0	2	1	1	4	5	2	5	1	2	1	0	1	2	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:128695838C>T	uc003elj.3	-	6	1076	c.880G>A	c.(880-882)GAT>AAT	p.D294N	KIAA1257_uc003elg.1_Missense_Mutation_p.D294N|KIAA1257_uc003eli.3_Missense_Mutation_p.D182N	NM_020741	NP_065792	Q9ULG3	K1257_HUMAN	hypothetical protein LOC57501	294											0						GTGGAAGAATCGTCCATTTTG	0.443													18	21					0	0	0	0	T	128695838	T	T	128695838	3	4	141	1	0	0	0	0	1	0	0	0	8257	884	31	1	361	1	KIAA1257	3	128695838	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	6418557	128695838	69326592	118	25393											
DZIP1L	199221	broad.mit.edu	37	chr3	137822454	137822454	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgctgaccacgctgctgctgGcccaggctggtctgcagccg	4	8	14	15	2	1	1	0	1	1	0	1	1	1	1	3	3	5	6	3	3	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:137822454G>A	uc003erq.2	-	2	723	c.360C>T	c.(358-360)GGC>GGT	p.G120G	DZIP1L_uc003err.1_Silent_p.G120G	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	120						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						GCTGCTGCTGGCCCAGGCTGG	0.662													10	14					0	0	0	0	A	137822454	A	A	137822454	2	1	141	1	0	0	0	0	0	0	0	1	4886	1190	42	4		4	DZIP1L	3	137822454	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	9126616	137822454	60199976	119	25394											
A4GNT	51146	broad.mit.edu	37	chr3	137850025	137850025	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagaggcagctggacttcAgggtgaactggtagaggaag	13	6	17	5	0	1	4	1	1	0	3	1	6	1	6	0	5	2	3	0	5	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:137850025A>T	uc003ers.2	-	2	276	c.74T>A	c.(73-75)CTG>CAG	p.L25Q		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	25	Helical; Signal-anchor for type II membrane protein; (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						GCTGGACTTCAGGGTGAACTG	0.567													14	21					0	0	0	0	T	137850025	T	T	137850025	3	4	141	1	0	0	0	0	1	0	0	0	7	188	7	5	956	5	A4GNT	3	137850025	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	27571	137850025	60172405	120	25395											
TFDP2	7029	broad.mit.edu	37	chr3	141682777	141682777	+	Frame_Shift_Del	DEL	C	-	-																															gctgctcattttgtcgatttCtctgtaccaggtttttgaaa																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:141682777delC	uc003eun.3	-	10	1140	c.761delG	c.(760-762)AGAfs	p.R254fs	TFDP2_uc003euk.3_Frame_Shift_Del_p.R167fs|TFDP2_uc010hur.2_Frame_Shift_Del_p.R194fs|TFDP2_uc003eul.3_Frame_Shift_Del_p.R194fs|TFDP2_uc011bnf.1_Frame_Shift_Del_p.R157fs|TFDP2_uc011bng.1_Frame_Shift_Del_p.R118fs|TFDP2_uc003eum.3_Frame_Shift_Del_p.R194fs	NM_006286	NP_006277	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization	254	Dimerization (Potential).|DCB1.				cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)	1						TTGTCGATTTCTCTGTACCAG	0.368													---	---	---								-	141682777	-	-	141682777	7	5	141	1	0	1	0	1	0	0	0	0	15864	913	32	0	595	0	TFDP2	3	141682777	Frame_Shift_Del	DEL	C	TCGA-CR-7370-01A-11D-2129-08	3832752	141682777	56339653	121	25396											
PLSCR4	57088	broad.mit.edu	37	chr3	145917674	145917674	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcattgtcatgatttctcGgcccatacaatcagtgaccc	9	12	7	13	1	3	2	2	2	1	0	4	2	3	2	2	1	2	1	2	1	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:145917674G>A	uc010huy.2	-	6	879	c.550C>T	c.(550-552)CGA>TGA	p.R184*	PLSCR4_uc010huz.2_Nonsense_Mutation_p.R184*|PLSCR4_uc003evt.3_Nonsense_Mutation_p.R184*|PLSCR4_uc010hva.2_Intron|PLSCR4_uc003evu.3_Intron	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	184	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						ATGATTTCTCGGCCCATACAA	0.502													15	15					0	0	0	0	A	145917674	A	A	145917674	4	1	141	1	0	0	0	0	0	1	0	0	12167	1124	39	1	455	1	PLSCR4	3	145917674	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4234897	145917674	52104756	122	25397											
MED12L	116931	broad.mit.edu	37	chr3	151082807	151082807	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaaccatatataataacGtgatgcctgcaaattcgaac	17	9	6	9	2	0	1	0	1	0	0	1	2	0	1	2	0	6	2	2	0	7	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:151082807G>C	uc003eyp.2	+	20	2931	c.2893G>C	c.(2893-2895)GTG>CTG	p.V965L	MED12L_uc011bnz.1_Missense_Mutation_p.V825L|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.V128L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	965					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATATAATAACGTGATGCCTGC	0.363													68	97					0	0	0	0	C	151082807	C	C	151082807	3	2	141	1	0	0	0	0	1	0	0	0	9482	1145	40	3	2971	3	MED12L	3	151082807	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	5165133	151082807	46939623	123	25398											
PLCH1	23007	broad.mit.edu	37	chr3	155218533	155218533	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccagtactctgctgtgtGtcttcctcatcatcagtact	6	16	7	12	0	5	0	3	0	2	0	6	0	6	0	2	0	4	3	2	0	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:155218533G>T	uc011bok.1	-	13	1996	c.1719C>A	c.(1717-1719)GAC>GAA	p.D573E	PLCH1_uc011boj.1_Missense_Mutation_p.D573E|PLCH1_uc011bol.1_Missense_Mutation_p.D555E	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	573					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCTGCTGTGTGTCTTCCTCAT	0.428													14	129					1.5739e-10	1.93244e-10	1	0	T	155218533	T	T	155218533	3	4	141	1	0	0	0	0	1	0	0	0	12092	1368	48	4	3421	4	PLCH1	3	155218533	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4135726	155218533	42803897	124	25399											
GMPS	8833	broad.mit.edu	37	chr3	155632262	155632262	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaaccctaccaatatcagAtgaagatagaaccccacgga	18	5	6	12	1	1	4	1	1	0	3	1	5	1	5	4	1	4	0	4	1	8	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:155632262A>G	uc003faq.2	+	8	1276	c.941A>G	c.(940-942)GAT>GGT	p.D314G	GMPS_uc011bom.1_Missense_Mutation_p.D215G	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	314					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCAATATCAGATGAAGATAGA	0.358			T	MLL	AML								8	84					0	0	0	0	G	155632262	G	G	155632262	3	3	141	1	0	0	0	0	1	0	0	0	6535	333	12	5	971	5	GMPS	3	155632262	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	413729	155632262	42390168	125	25400											
VEPH1	79674	broad.mit.edu	37	chr3	157099093	157099093	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttttaatctccagcaggaGaatatggtgaaacgaatgct	13	11	10	7	1	1	2	0	1	1	1	2	4	1	2	1	2	3	3	1	2	5	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:157099093G>T	uc003fbj.1	-	7	1296	c.979C>A	c.(979-981)CTC>ATC	p.L327I	VEPH1_uc003fbk.1_Missense_Mutation_p.L327I|VEPH1_uc010hvu.1_Missense_Mutation_p.L327I	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	327						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TCCAGCAGGAGAATATGGTGA	0.498													42	48					3.43241e-23	5.01187e-23	1	0	T	157099093	T	T	157099093	3	4	141	1	0	0	0	0	1	0	0	0	17222	942	33	2	1554	2	VEPH1	3	157099093	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1466831	157099093	40923337	126	25401											
SI	6476	broad.mit.edu	37	chr3	164737463	164737463	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttaaatgctgtatgttccActtccccaaaaccatatata	13	13	4	11	0	0	0	0	0	0	0	2	0	2	0	4	0	2	4	4	0	8	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:164737463A>T	uc003fei.2	-	28	3412	c.3350T>A	c.(3349-3351)GTG>GAG	p.V1117E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1117	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGTATGTTCCACTTCCCCAAA	0.438										HNSCC(35;0.089)			19	76					0	0	0	0	T	164737463	T	T	164737463	3	4	141	1	0	0	0	0	1	0	0	0	14362	159	6	5	2217	5	SI	3	164737463	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	7638370	164737463	33284967	127	25402											
SI	6476	broad.mit.edu	37	chr3	164750444	164750444	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctaaggtagttccttcctGatatgatgaatgtgtgcaca	10	14	10	7	0	0	3	0	3	0	0	2	3	2	3	2	1	2	4	2	1	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:164750444G>T	uc003fei.2	-	24	2664	c.2602C>A	c.(2602-2604)CAG>AAG	p.Q868K		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	868	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTTCCTTCCTGATATGATGAA	0.343										HNSCC(35;0.089)			16	21					2.35188e-11	2.94689e-11	1	0	T	164750444	T	T	164750444	3	4	141	1	0	0	0	0	1	0	0	0	14362	1299	45	2	2981	2	SI	3	164750444	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	12981	164750444	33271986	128	25403											
HTR3C	170572	broad.mit.edu	37	chr3	183776222	183776222	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctcccttccagtggacagCatgctgctgggcatggacaa	8	8	12	13	0	0	0	0	0	0	0	2	2	2	2	3	3	3	4	3	3	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:183776222C>A	uc003fmk.2	+	6	601	c.567C>A	c.(565-567)AGC>AGA	p.S189R		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine receptor 3 subunit C	189	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CAGTGGACAGCATGCTGCTGG	0.567													6	90					0.00198382	0.00207142	1	0	A	183776222	A	A	183776222	3	1	141	1	0	0	0	0	1	0	0	0	7485	709	25	4	589	4	HTR3C	3	183776222	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	19025778	183776222	14246208	129	25404											
HTR3C	170572	broad.mit.edu	37	chr3	183776244	183776244	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgctgctgggcatggacaagGaggtgtgggagatcacagac	10	7	17	7	0	1	2	1	0	0	2	1	5	1	4	0	5	2	3	0	5	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:183776244G>A	uc003fmk.2	+	6	623	c.589G>A	c.(589-591)GAG>AAG	p.E197K		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine receptor 3 subunit C	197	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CATGGACAAGGAGGTGTGGGA	0.582													9	108					0	0	0	0	A	183776244	A	A	183776244	3	1	141	1	0	0	0	0	1	0	0	0	7485	1175	41	2	611	2	HTR3C	3	183776244	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	22	183776244	14246186	130	25405											
MASP1	5648	broad.mit.edu	37	chr3	186944202	186944202	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcactcactcacccaggatGattttgaagtcagaagggct	11	10	9	11	0	4	3	4	2	0	1	4	4	4	4	1	2	0	1	1	2	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:186944202G>T	uc003frh.1	-	12	1880	c.1548C>A	c.(1546-1548)ATC>ATA	p.I516I		NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	516	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CACCCAGGATGATTTTGAAGT	0.567													6	21					5.9392e-07	6.69759e-07	1	0	T	186944202	T	T	186944202	2	4	141	1	0	0	0	0	0	0	0	1	9375	1280	45	2		2	MASP1	3	186944202	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3167958	186944202	11078228	131	25406											
ATP13A5	344905	broad.mit.edu	37	chr3	193042775	193042775	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccatggcacagcctggcCtgaggcaaagctgtgggctt	7	8	14	12	0	0	1	0	1	0	0	1	1	1	1	3	4	2	5	3	4	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:193042775C>A	uc011bsq.1	-	14	1552	c.1552G>T	c.(1552-1554)GGC>TGC	p.G518C		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	518					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		ACAGCCTGGCCTGAGGCAAAG	0.502													36	284					2.42023e-17	3.27312e-17	1	0	A	193042775	A	A	193042775	3	1	141	1	0	0	0	0	1	0	0	0	1129	681	24	4	2170	4	ATP13A5	3	193042775	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	6098573	193042775	4979655	132	25407											
ATP13A3	79572	broad.mit.edu	37	chr3	194149602	194149602	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accactaccaaaatgattgcCagatcaatgaagagaaactg	18	7	7	9	0	1	4	1	2	0	2	1	5	1	4	3	0	3	0	3	0	6	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:194149602C>T	uc003fty.3	-	27	3321	c.2919G>A	c.(2917-2919)CTG>CTA	p.L973L		NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	973	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AAATGATTGCCAGATCAATGA	0.274													12	94					0	0	0	0	T	194149602	T	T	194149602	2	4	141	1	0	0	0	0	0	0	0	1	1127	581	21	4		4	ATP13A3	3	194149602	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1106827	194149602	3872828	133	25408											
TMEM44	93109	broad.mit.edu	37	chr3	194344010	194344010	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaggcagcaacgctaccCagcaggtagccgaggatctc	12	4	11	14	2	1	0	0	0	1	0	2	2	1	1	3	3	5	5	3	3	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:194344010C>A	uc010hzn.2	-	5	724	c.555G>T	c.(553-555)CTG>CTT	p.L185L	TMEM44_uc003fue.2_Silent_p.L185L|TMEM44_uc003fud.2_Silent_p.L185L|TMEM44_uc003fuf.2_Silent_p.L185L|TMEM44_uc011bsv.1_Silent_p.L185L|TMEM44_uc003fuh.1_RNA	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	185	Helical; (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		CAACGCTACCCAGCAGGTAGC	0.572													28	17					4.15321e-07	4.698e-07	1	0	A	194344010	A	A	194344010	2	1	141	1	0	0	0	0	0	0	0	1	16234	581	21	4		4	TMEM44	3	194344010	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	194408	194344010	3678420	134	25409											
MUC4	4585	broad.mit.edu	37	chr3	195479980	195479980	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagcagcggctgtcagtgaaGgctggggggcaggtgcacat	9	6	18	8	1	1	1	1	1	0	0	1	1	1	1	0	6	3	5	0	6	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:195479980G>A	uc011bto.1	-	21	15526	c.15066C>T	c.(15064-15066)GCC>GCT	p.A5022A	MUC4_uc010hzq.2_Silent_p.A7A|MUC4_uc003fuz.2_Silent_p.A748A|MUC4_uc003fva.2_Silent_p.A630A|MUC4_uc003fvb.2_Silent_p.A666A|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Silent_p.A666A|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Silent_p.A630A|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Silent_p.A714A|MUC4_uc011bti.1_Silent_p.A714A|MUC4_uc011btj.1_Silent_p.A891A|MUC4_uc011btk.1_Silent_p.A630A|MUC4_uc011btl.1_Silent_p.A659A|MUC4_uc011btm.1_Silent_p.A839A|MUC4_uc011btn.1_Silent_p.A630A|MUC4_uc003fvo.2_Silent_p.A914A|MUC4_uc003fvp.2_Silent_p.A863A	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1907	EGF-like 1.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTCAGTGAAGGCTGGGGGGC	0.592													77	191					0	0	0	0	A	195479980	A	A	195479980	2	1	141	1	0	0	0	0	0	0	0	1	10031	987	35	4		4	MUC4	3	195479980	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1135970	195479980	2542450	135	25410											
LMLN	89782	broad.mit.edu	37	chr3	197707351	197707351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctcttatgcagcctattGtcagcaggaagcaaacatgg	12	10	9	10	0	2	0	1	0	1	0	3	1	2	1	1	2	5	3	1	2	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:197707351G>A	uc011buo.1	+	6	726	c.704G>A	c.(703-705)TGT>TAT	p.C235Y	LMLN_uc003fyt.2_Missense_Mutation_p.C183Y|LMLN_uc010iar.2_Missense_Mutation_p.C235Y|LMLN_uc010ias.2_Missense_Mutation_p.C183Y|LMLN_uc003fyu.2_5'UTR	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	235					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		GCAGCCTATTGTCAGCAGGAA	0.433													13	277					0	0	0	0	A	197707351	A	A	197707351	3	1	141	1	0	0	0	0	1	0	0	0	8889	1377	48	4	726	4	LMLN	3	197707351	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2227371	197707351	315079	136	25411											
CWH43	80157	broad.mit.edu	37	chr4	49000563	49000563	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtttgatctggtgggttaCaggtatgtggaatttacctg	7	16	14	4	0	1	1	0	1	1	0	1	2	1	2	1	5	2	3	1	5	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:49000563C>T	uc003gyv.2	+	6	982	c.800C>T	c.(799-801)ACA>ATA	p.T267I	CWH43_uc011bzl.1_Missense_Mutation_p.T240I	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	267					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						TGGTGGGTTACAGGTATGTGG	0.453													48	20					0	0	0	0	T	49000563	T	T	49000563	3	4	141	1	0	0	0	0	1	0	0	0	4090	478	17	4	822	4	CWH43	4	49000563	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08		49000563	142153713	137	25412											
EXOC1	55763	broad.mit.edu	37	chr4	56744196	56744196	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagctgatggagtggctaaaGagtacagattatggaaaata	17	9	12	3	0	0	3	0	1	0	2	0	5	0	5	0	3	2	3	0	3	8	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:56744196G>A	uc003hbe.1	+	9	1346	c.1188G>A	c.(1186-1188)AAG>AAA	p.K396K	EXOC1_uc003hbf.1_Silent_p.K396K|EXOC1_uc003hbg.1_Silent_p.K396K	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	396					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					AGTGGCTAAAGAGTACAGATT	0.383													46	31					0	0	0	0	A	56744196	A	A	56744196	2	1	141	1	0	0	0	0	0	0	0	1	5325	933	33	2		2	EXOC1	4	56744196	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	7743633	56744196	134410080	138	25413											
NUP54	53371	broad.mit.edu	37	chr4	77039260	77039260	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgcatttagttcaccctGaatcgtatccagctgaactc	10	12	8	11	1	1	2	1	2	0	0	4	2	2	2	2	1	3	4	2	1	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:77039260G>A	uc003hjs.2	-	10	1380	c.1252C>T	c.(1252-1254)CAG>TAG	p.Q418*	NUP54_uc010ije.2_Nonsense_Mutation_p.Q136*|NUP54_uc011cbs.1_Nonsense_Mutation_p.Q238*|NUP54_uc011cbt.1_Nonsense_Mutation_p.Q370*|NUP54_uc003hjt.2_Nonsense_Mutation_p.Q202*	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	418	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2						AGTTCACCCTGAATCGTATCC	0.383													10	55					0	0	0	0	A	77039260	A	A	77039260	4	1	141	1	0	0	0	0	0	1	0	0	10821	1299	45	2	283	2	NUP54	4	77039260	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	20295064	77039260	114115016	139	25414											
GRID2	2895	broad.mit.edu	37	chr4	94377028	94377028	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtctactggtctacctcttGaactggcttaatcccccacg	7	12	8	14	1	3	1	0	1	3	0	4	1	4	1	3	3	3	1	3	3	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:94377028G>C	uc011cdt.1	+	11	2019	c.1761G>C	c.(1759-1761)TTG>TTC	p.L587F	GRID2_uc011cdu.1_Missense_Mutation_p.L492F	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	587	Helical; (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TCTACCTCTTGAACTGGCTTA	0.453													8	74					0	0	0	0	C	94377028	C	C	94377028	3	2	141	1	0	0	0	0	1	0	0	0	6811	1281	45	2	1803	2	GRID2	4	94377028	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	17337768	94377028	96777248	140	25415											
PDHA2	5161	broad.mit.edu	37	chr4	96762223	96762223	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacgagaagaaattcaggaaGtaagaagtaagagggatcct	18	6	12	5	1	1	4	1	0	0	4	2	7	2	6	1	2	0	2	1	2	6	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:96762223G>A	uc003htr.3	+	1	985	c.922G>A	c.(922-924)GTA>ATA	p.V308I		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	308					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	AATTCAGGAAGTAAGAAGTAA	0.438													38	22					0	0	0	0	A	96762223	A	A	96762223	3	1	141	1	0	0	0	0	1	0	0	0	11719	1029	36	4	924	4	PDHA2	4	96762223	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2385195	96762223	94392053	141	25416											
DDIT4L	115265	broad.mit.edu	37	chr4	101111077	101111077	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggctctctgggtgatagcCacagtccagcaattctgaaa	11	9	10	11	0	2	2	0	2	2	0	4	2	3	2	2	2	2	2	2	2	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:101111077C>A	uc003hvq.2	-	2	267	c.64G>T	c.(64-66)GGC>TGC	p.G22C		NM_145244	NP_660287	Q96D03	DDT4L_HUMAN	DNA-damage-inducible transcript 4-like	22					negative regulation of signal transduction	cytoplasm				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;5.75e-09)		GGGTGATAGCCACAGTCCAGC	0.592													27	16					1.08312e-15	1.44877e-15	1	0	A	101111077	A	A	101111077	3	1	141	1	0	0	0	0	1	0	0	0	4349	594	21	4	525	4	DDIT4L	4	101111077	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4348854	101111077	90043199	142	25417											
NHEDC1	150159	broad.mit.edu	37	chr4	103870556	103870556	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcctaagattgaccaggtCatacaccatatcacaaacag	16	7	7	11	0	2	2	2	1	0	1	2	3	2	2	3	1	3	0	3	1	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:103870556C>A	uc003hww.2	-	4	362	c.240G>T	c.(238-240)ATG>ATT	p.M80I	NHEDC1_uc003hwu.2_Missense_Mutation_p.M80I|NHEDC1_uc010ilm.2_5'UTR|NHEDC1_uc003hwv.2_Intron|NHEDC1_uc011cev.1_Intron	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	80	Helical; (Potential).					integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		TTGACCAGGTCATACACCATA	0.338													37	35					9.14704e-12	1.15401e-11	1	0	A	103870556	A	A	103870556	3	1	141	1	0	0	0	0	1	0	0	0	10454	826	29	2	1443	2	NHEDC1	4	103870556	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2759479	103870556	87283720	143	25418											
ANK2	287	broad.mit.edu	37	chr4	114238907	114238907	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtctcacactctgagccatgCctcctacctgagggacagtg	8	9	10	14	0	2	2	1	2	2	0	4	3	3	3	4	1	3	0	4	1	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:114238907C>T	uc003ibe.3	+	25	2838	c.2738C>T	c.(2737-2739)GCC>GTC	p.A913V	ANK2_uc003ibd.3_Missense_Mutation_p.A892V|ANK2_uc003ibf.3_Missense_Mutation_p.A913V|ANK2_uc011cgc.1_Missense_Mutation_p.A122V|ANK2_uc003ibg.3_5'Flank|ANK2_uc003ibc.2_Missense_Mutation_p.A889V|ANK2_uc011cgb.1_Missense_Mutation_p.A928V	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	913					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGAGCCATGCCTCCTACCTG	0.527													26	18					0	0	0	0	T	114238907	T	T	114238907	3	4	141	1	0	0	0	0	1	0	0	0	621	739	26	4	2861	4	ANK2	4	114238907	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	10368351	114238907	76915369	144	25419											
ANK2	287	broad.mit.edu	37	chr4	114275560	114275560	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaaaaacacccgccagtatCgcctgggagaacagaaaaac	18	3	9	11	2	0	3	0	0	0	3	1	4	0	3	3	1	3	1	3	1	6	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:114275560C>T	uc003ibe.3	+	38	5886	c.5786C>T	c.(5785-5787)TCG>TTG	p.S1929L	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.S1944L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1896	Repeat-rich region.|Repeat A; approximate.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCGCCAGTATCGCCTGGGAGA	0.522													12	27					0	0	0	0	T	114275560	T	T	114275560	3	4	141	1	0	0	0	0	1	0	0	0	621	893	31	1	6001	1	ANK2	4	114275560	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	36653	114275560	76878716	145	25420											
TNIP3	79931	broad.mit.edu	37	chr4	122075747	122075748	+	Nonsense_Mutation	DNP	CC	AA	AA																															acattcgtaatgttccttttCcttgttcgcaagagtatttt																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:122075747_122075748CC>AA	uc010ing.2	-	5	646_647	c.450_451GG>TT	c.(448-453)AAGGAA>AATTAA	p.150_151KE>N*	TNIP3_uc010inh.2_Nonsense_Mutation_p.150_151KE>N*|TNIP3_uc011cgj.1_Nonsense_Mutation_p.208_209KE>N*|TNIP3_uc010ini.2_Nonsense_Mutation_p.150_151KE>N*	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	150_151	Potential.									ovary(1)	1						TGTTCCTTTTCCTTGTTCGCAA	0.347													19	14					0	0	0	0	AA	122075748	AA	AA	122075747	4	1	141	1	0	0	0	0	0	1	0	0	16382	864	30	2	554	2	TNIP3	4	122075747	Nonsense_Mutation	DNP	CC	TCGA-CR-7370-01A-11D-2129-08	7800187	122075747	69078529	146	25421											
ANKRD50	57182	broad.mit.edu	37	chr4	125591844	125591844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgttcaataagtgcttcaCatatcaatctgtgcccttca	10	15	5	11	0	5	0	4	0	1	0	5	0	5	0	1	0	2	2	1	0	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:125591844C>T	uc003ifg.3	-	3	2854	c.2588G>A	c.(2587-2589)TGT>TAT	p.C863Y	ANKRD50_uc011cgo.1_Missense_Mutation_p.C684Y|ANKRD50_uc010inw.2_Missense_Mutation_p.C863Y	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	863	ANK 12.									central_nervous_system(1)	1						AAGTGCTTCACATATCAATCT	0.408													63	29					0	0	0	0	T	125591844	T	T	125591844	3	4	141	1	0	0	0	0	1	0	0	0	677	478	17	4	1705	4	ANKRD50	4	125591844	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3516097	125591844	65562432	147	25422											
FAT4	79633	broad.mit.edu	37	chr4	126336137	126336137	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaaagtcctaaaagctttgGatcgggaaagtcagtccttc	12	11	9	9	1	2	0	2	0	0	0	6	2	4	2	2	2	1	1	2	2	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:126336137G>T	uc003ifj.3	+	5	6019	c.6019G>T	c.(6019-6021)GAT>TAT	p.D2007Y	FAT4_uc011cgp.1_Missense_Mutation_p.D305Y	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2007	Cadherin 19.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AAAAGCTTTGGATCGGGAAAG	0.443													75	48					2.15109e-50	3.39816e-50	1	0	T	126336137	T	T	126336137	3	4	141	1	0	0	0	0	1	0	0	0	5724	1174	41	2	6037	2	FAT4	4	126336137	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	744293	126336137	64818139	148	25423											
INTU	27152	broad.mit.edu	37	chr4	128637585	128637585	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattgttctttgggttaacCttgtagctgtgctttcttga	7	19	9	6	0	2	1	0	1	2	0	2	1	2	1	1	1	3	5	1	1	3	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:128637585C>T	uc003ifk.1	+	16	2893	c.2823C>T	c.(2821-2823)ACC>ACT	p.T941T	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	941										ovary(1)	1						TTGGGTTAACCTTGTAGCTGT	0.358													22	17					0	0	0	0	T	128637585	T	T	128637585	2	4	141	1	0	0	0	0	0	0	0	1	7825	668	24	4		4	INTU	4	128637585	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2301448	128637585	62516691	149	25424											
LRAT	9227	broad.mit.edu	37	chr4	155665906	155665906	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcaacgaggaggtggcgcGgagggctgaaaagctgctgg	9	5	19	8	3	1	1	1	1	0	0	1	4	1	3	0	6	3	4	0	6	3	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:155665906G>A	uc003iom.1	+	1	755	c.428G>A	c.(427-429)CGG>CAG	p.R143Q	uc003iol.2_Intron|LRAT_uc003ion.1_Missense_Mutation_p.R143Q	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	143	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	GAGGTGGCGCGGAGGGCTGAA	0.582													33	19					0	0	0	0	A	155665906	A	A	155665906	3	1	141	1	0	0	0	0	1	0	0	0	8980	1116	39	1	430	1	LRAT	4	155665906	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	27028321	155665906	35488370	150	25425											
TDO2	6999	broad.mit.edu	37	chr4	156831334	156831334	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aactgctacttaaatctgagCaggaaaagacacttctggaa	16	9	8	8	0	2	2	0	1	2	1	2	4	2	4	0	2	4	2	0	2	7	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:156831334C>A	uc003ipf.1	+	6	653	c.589C>A	c.(589-591)CAG>AAG	p.Q197K		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	197					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	TAAATCTGAGCAGGAAAAGAC	0.328													34	26					3.2961e-07	3.73422e-07	1	0	A	156831334	A	A	156831334	3	1	141	1	0	0	0	0	1	0	0	0	15793	711	25	4	611	4	TDO2	4	156831334	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1165428	156831334	34322942	151	25426											
FAT1	2195	broad.mit.edu	37	chr4	187629115	187629116	+	Frame_Shift_Del	DEL	CC	-	-																															cgatcgctttaatgacaataCccccgagttggggtttaaac																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:187629115_187629116delCC	uc003izf.2	-	2	2054_2055	c.1866_1867delGG	c.(1864-1869)GGGGTAfs	p.G622fs	FAT1_uc010iso.1_Frame_Shift_Del_p.G622fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	622_623	Extracellular (Potential).|Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AATGACAATACCCCCGAGTTGG	0.426										HNSCC(5;0.00058)			---	---	---								-	187629116	-	-	187629115	7	5	141	1	0	1	0	1	0	0	0	0	5721	507	18	0	12003	0	FAT1	4	187629115	Frame_Shift_Del	DEL	CC	TCGA-CR-7370-01A-11D-2129-08	30797781	187629115	3525161	152	25427											
FRG1	2483	broad.mit.edu	37	chr4	190878615	190878615	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcaatgaagcaggggacatAgaagcaaaaagtaaaacagc	20	4	11	6	0	0	2	0	1	0	1	0	3	0	3	0	2	5	4	0	2	8	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:190878615A>T	uc003izs.2	+	6	686	c.495A>T	c.(493-495)ATA>ATT	p.I165I		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	165					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		CAGGGGACATAGAAGCAAAAA	0.378													22	113					0	0	0	0	T	190878615	T	T	190878615	2	4	141	1	0	0	0	0	0	0	0	1	6080	410	15	5		5	FRG1	4	190878615	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	3249500	190878615	275661	153	25428											
TPPP	11076	broad.mit.edu	37	chr5	677917	677917	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacggtcacgttcctgccgtCgatcacctggcagtccttgc	5	10	11	15	4	2	0	2	0	0	0	5	2	4	0	4	2	2	2	4	2	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:677917C>A	uc003jbg.3	-	1	977	c.259G>T	c.(259-261)GAC>TAC	p.D87Y	TPPP_uc003jbh.3_Missense_Mutation_p.D87Y	NM_007030	NP_008961	O94811	TPPP_HUMAN	tubulin polymerization promoting protein	87	Mediates interaction with LIMK1.				microtubule bundle formation|microtubule polymerization|positive regulation of protein polymerization	nucleus|perinuclear region of cytoplasm|soluble fraction	calcium ion binding|microtubule binding				0		Ovarian(839;0.0563)	Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)	GBM - Glioblastoma multiforme(108;0.0191)		TTCCTGCCGTCGATCACCTGG	0.642													33	56					8.4185e-14	1.09605e-13	1	0	A	677917	A	A	677917	3	1	141	1	0	0	0	0	1	0	0	0	16480	884	31	3	412	3	TPPP	5	677917	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08		677917	180237343	154	25429											
NSUN2	54888	broad.mit.edu	37	chr5	6609987	6609987	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagattttttcaccaatacTgccacaaaaaaccctccagt	15	10	4	12	0	1	1	1	0	0	1	2	2	2	1	4	0	3	0	4	0	6	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:6609987T>A	uc003jdu.2	-	12	1340	c.1275A>T	c.(1273-1275)GCA>GCT	p.A425A	NSUN2_uc003jdt.2_Silent_p.A189A|NSUN2_uc011cmk.1_Silent_p.A390A|NSUN2_uc003jdv.2_Silent_p.A189A	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	425						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						TCACCAATACTGCCACAAAAA	0.328													35	40					0	0	0	0	A	6609987	A	A	6609987	2	1	141	1	0	0	0	0	0	0	0	1	10732	1567	55	5		5	NSUN2	5	6609987	Silent	SNP	T	TCGA-CR-7370-01A-11D-2129-08	5932070	6609987	174305273	155	25430											
FASTKD3	79072	broad.mit.edu	37	chr5	7867502	7867502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgagttctagtgtcacacaaCctgaactgtgcagtgtaatc	11	12	9	9	0	2	2	1	2	1	0	3	2	2	2	1	0	3	3	1	0	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:7867502C>T	uc003jeb.2	-	2	832	c.695G>A	c.(694-696)GGT>GAT	p.G232D	FASTKD3_uc011cmp.1_5'UTR|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	232					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TGTCACACAACCTGAACTGTG	0.418													22	74					0	0	0	0	T	7867502	T	T	7867502	3	4	141	1	0	0	0	0	1	0	0	0	5719	507	18	4	1317	4	FASTKD3	5	7867502	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1257515	7867502	173047758	156	25431											
MTRR	4552	broad.mit.edu	37	chr5	7897181	7897181	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatatattatatttcagaaaAgagctcagacatttccttaa	16	15	4	6	0	2	3	2	0	0	3	3	3	3	3	1	0	1	1	1	0	8	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:7897181A>G	uc003jed.2	+	14	1884	c.1854A>G	c.(1852-1854)AAA>AAG	p.K618K	MTRR_uc003jee.3_Silent_p.K591K|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	618					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	ATTTCAGAAAAGAGCTCAGAC	0.388													15	20					0	0	0	0	G	7897181	G	G	7897181	2	3	141	1	0	0	0	0	0	0	0	1	10014	69	3	5		5	MTRR	5	7897181	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	29679	7897181	173018079	157	25432											
SEMA5A	9037	broad.mit.edu	37	chr5	9202224	9202224	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccagcaggaagcgcccacCaatatcgttcttgcacaccc	10	8	7	16	2	1	0	0	0	1	0	3	1	2	1	4	1	3	3	4	1	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:9202224C>A	uc003jek.2	-	9	1487	c.775G>T	c.(775-777)GGT>TGT	p.G259C		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	259	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						AAGCGCCCACCAATATCGTTC	0.507													30	59					4.02929e-09	4.78682e-09	1	0	A	9202224	A	A	9202224	3	1	141	1	0	0	0	0	1	0	0	0	14102	594	21	4	2509	4	SEMA5A	5	9202224	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1305043	9202224	171713036	158	25433											
PRDM9	56979	broad.mit.edu	37	chr5	23522738	23522738	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagattgtgagatgtgtcAgaacttcttcattgacagct	10	14	9	8	0	3	4	2	2	1	3	4	5	4	4	1	0	2	1	1	0	1	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:23522738A>G	uc003jgo.2	+	8	808	c.626A>G	c.(625-627)CAG>CGG	p.Q209R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	209					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GAGATGTGTCAGAACTTCTTC	0.483										HNSCC(3;0.000094)			20	15					0	0	0	0	G	23522738	G	G	23522738	3	3	141	1	0	0	0	0	1	0	0	0	12525	188	7	5	652	5	PRDM9	5	23522738	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	14320514	23522738	157392522	159	25434											
CDH6	1004	broad.mit.edu	37	chr5	31323142	31323142	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccgaagcccttttcctaccCcgacggactccaacagctcg	8	7	7	19	4	0	0	0	0	0	0	3	3	2	1	6	1	4	1	6	1	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:31323142C>A	uc003jhe.1	+	12	2426	c.2100C>A	c.(2098-2100)CCC>CCA	p.P700P		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	700	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TTTTCCTACCCCGACGGACTC	0.517													15	50					0.000308642	0.000326929	1	0	A	31323142	A	A	31323142	2	1	141	1	0	0	0	0	0	0	0	1	3129	610	22	4		4	CDH6	5	31323142	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	7800404	31323142	149592118	160	25435											
TARS	6897	broad.mit.edu	37	chr5	33461070	33461070	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgcggctagctgattttggGgtacttcataggaacgagct	8	12	13	8	2	1	1	1	1	0	0	1	3	1	2	0	4	5	4	0	4	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:33461070G>A	uc003jhy.2	+	12	1609	c.1314G>A	c.(1312-1314)GGG>GGA	p.G438G	TARS_uc011cob.1_Silent_p.G426G|TARS_uc010iup.1_Silent_p.G379G|TARS_uc011coc.1_Silent_p.G459G|TARS_uc003jhz.2_Silent_p.G334G|TARS_uc011cod.1_Silent_p.G317G	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	438					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	CTGATTTTGGGGTACTTCATA	0.502													18	48					0	0	0	0	A	33461070	A	A	33461070	2	1	141	1	0	0	0	0	0	0	0	1	15625	1219	43	4		4	TARS	5	33461070	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2137928	33461070	147454190	161	25436											
SPEF2	79925	broad.mit.edu	37	chr5	35654802	35654802	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggaaattgttaatggacCagttaatagcccacgaagca	14	8	11	8	2	0	0	0	0	0	0	0	3	0	2	2	3	2	3	2	3	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:35654802C>T	uc003jjo.2	+	7	1063	c.952C>T	c.(952-954)CAG>TAG	p.Q318*	SPEF2_uc003jjn.1_Nonsense_Mutation_p.Q318*|SPEF2_uc003jjq.3_Nonsense_Mutation_p.Q318*	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	318					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTTAATGGACCAGTTAATAGC	0.383													45	43					0	0	0	0	T	35654802	T	T	35654802	4	4	141	1	0	0	0	0	0	1	0	0	15101	595	21	4	978	4	SPEF2	5	35654802	Nonsense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2193732	35654802	145260458	162	25437											
SKP2	6502	broad.mit.edu	37	chr5	36184011	36184011	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgccctcaaacatacagaacTtccaaactcaagtccagcca	15	7	4	15	0	2	1	2	0	0	1	4	1	4	1	4	0	6	0	4	0	5	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:36184011T>G	uc003jkd.2	+	10	1307	c.1131T>G	c.(1129-1131)ACT>ACG	p.T377T		NM_032637	NP_116026	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 2	Error:Variant_position_missing_in_Q13309_after_alignment					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CATACAGAACTTCCAAACTCA	0.363													7	71					0	0	0	0	G	36184011	G	G	36184011	2	3	141	1	0	0	0	0	0	0	0	1	14427	1596	56	5		5	SKP2	5	36184011	Silent	SNP	T	TCGA-CR-7370-01A-11D-2129-08	529209	36184011	144731249	163	25438											
PTGER4	5734	broad.mit.edu	37	chr5	40681505	40681505	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgtggacaagcgattggcggGcctcacgctctttgcagtct	6	10	13	12	4	3	0	1	0	2	0	3	2	3	1	1	3	2	2	1	3	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:40681505G>T	uc003jlz.2	+	2	1002	c.410G>T	c.(409-411)GGC>GTC	p.G137V		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	137	Helical; Name=4; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						CGATTGGCGGGCCTCACGCTC	0.597											OREG0016588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	58	74					9.59835e-30	1.45064e-29	1	0	T	40681505	T	T	40681505	3	4	141	1	0	0	0	0	1	0	0	0	12808	1203	42	4	412	4	PTGER4	5	40681505	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4497494	40681505	140233755	164	25439											
HEATR7B2	133558	broad.mit.edu	37	chr5	41038946	41038946	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccactgctccatagatgacCatgacatctgtcttggtcag	9	11	9	12	0	3	3	1	2	2	1	4	3	4	3	3	1	1	1	3	1	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:41038946C>A	uc003jmj.3	-	21	2596	c.2106G>T	c.(2104-2106)ATG>ATT	p.M702I	HEATR7B2_uc003jmi.3_Missense_Mutation_p.M257I	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	702							binding			ovary(6)|central_nervous_system(2)	8						CATAGATGACCATGACATCTG	0.453													19	57					7.41877e-09	8.7427e-09	1	0	A	41038946	A	A	41038946	3	1	141	1	0	0	0	0	1	0	0	0	7074	594	21	4	2739	4	HEATR7B2	5	41038946	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	357441	41038946	139876314	165	25440											
MGC42105	167359	broad.mit.edu	37	chr5	43280809	43280809	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagagggataagacacacatCcaaattttgctcgattttat	14	12	7	8	1	0	2	0	0	0	2	2	4	1	3	1	1	1	1	1	1	3	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:43280809C>G	uc003jno.2	+	4	2170	c.1289C>G	c.(1288-1290)TCC>TGC	p.S430C		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	430							ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						AGACACACATCCAAATTTTGC	0.403													25	33					0	0	0	0	G	43280809	G	G	43280809	3	3	141	1	0	0	0	0	1	0	0	0	9605	855	30	2	1299	2	MGC42105	5	43280809	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2241863	43280809	137634451	166	25441											
CCL28	56477	broad.mit.edu	37	chr5	43382139	43382139	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgacacagattcttctGcgcttgacatgaaggctgtt	8	12	12	9	1	2	4	0	3	2	1	2	4	2	4	0	2	1	4	0	2	1	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:43382139G>T	uc003jnu.2	-	3	277	c.207C>A	c.(205-207)CGC>CGA	p.R69R	CCL28_uc003jns.2_RNA|CCL28_uc003jnt.2_RNA|CCL28_uc010ivn.2_Silent_p.R22R	NM_148672	NP_683513	Q9NRJ3	CCL28_HUMAN	chemokine (C-C motif) ligand 28 precursor	69					chemotaxis|immune response	extracellular space	chemokine activity			ovary(1)|kidney(1)	2						AGATTCTTCTGCGCTTGACAT	0.398													12	60					6.40141e-05	6.85999e-05	1	0	T	43382139	T	T	43382139	2	4	141	1	0	0	0	0	0	0	0	1	2913	1306	46	4		4	CCL28	5	43382139	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	101330	43382139	137533121	167	25442											
MAP1B	4131	broad.mit.edu	37	chr5	71492252	71492252	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagaggaggctgatgaggagGacaaagctgaagatgccaga	16	4	16	5	0	0	6	0	3	0	3	0	9	0	9	1	4	2	2	1	4	3	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:71492252G>A	uc003kbw.3	+	5	3311	c.3070G>A	c.(3070-3072)GAC>AAC	p.D1024N	MAP1B_uc010iyw.1_Missense_Mutation_p.D1041N|MAP1B_uc010iyx.1_Missense_Mutation_p.D898N|MAP1B_uc010iyy.1_Missense_Mutation_p.D898N	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1024						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TGATGAGGAGGACAAAGCTGA	0.532													37	11					0	0	0	0	A	71492252	A	A	71492252	3	1	141	1	0	0	0	0	1	0	0	0	9281	1174	41	2	3088	2	MAP1B	5	71492252	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	28110113	71492252	109423008	168	25443											
AP3B1	8546	broad.mit.edu	37	chr5	77385258	77385258	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacaagtgtaaaccttcaaGatcagccatcaaacttggag	15	9	8	9	0	3	2	3	1	0	1	3	3	3	3	2	1	3	1	2	1	5	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:77385258G>T	uc003kfj.2	-	22	2661	c.2536C>A	c.(2536-2538)CTT>ATT	p.L846I		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	846					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		AAACCTTCAAGATCAGCCATC	0.393									Hermansky-Pudlak_syndrome				28	14					1.5548e-18	2.14223e-18	1	0	T	77385258	T	T	77385258	3	4	141	1	0	0	0	0	1	0	0	0	744	942	33	2	772	2	AP3B1	5	77385258	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	5893006	77385258	103530002	169	25444											
NR2F1	7025	broad.mit.edu	37	chr5	92923837	92923837	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcgagctggccgcgcgcctGctcttcagcgccgtcgagtg	3	8	15	15	7	2	0	1	0	1	0	3	2	2	0	3	1	4	2	3	1	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:92923837G>C	uc003kkj.2	+	2	2365	c.678G>C	c.(676-678)CTG>CTC	p.L226L		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	226					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		CCGCGCGCCTGCTCTTCAGCG	0.652													40	28					0	0	0	0	C	92923837	C	C	92923837	2	2	141	1	0	0	0	0	0	0	0	1	10681	1306	46	4		4	NR2F1	5	92923837	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	15538579	92923837	87991423	170	25445											
TRIM36	55521	broad.mit.edu	37	chr5	114472790	114472790	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtctgagctgcaggtctaaAgctcttcaaagattctgtgg	10	12	11	8	0	5	2	1	1	4	1	5	2	5	2	0	2	3	3	0	2	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:114472790A>G	uc003kqs.2	-	7	1662	c.1153T>C	c.(1153-1155)TTT>CTT	p.F385L	TRIM36_uc011cwc.1_Missense_Mutation_p.F373L|TRIM36_uc003kqt.2_Missense_Mutation_p.F230L	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	385	COS.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		GCAGGTCTAAAGCTCTTCAAA	0.333													12	13					0	0	0	0	G	114472790	G	G	114472790	3	3	141	1	0	0	0	0	1	0	0	0	16577	72	3	5	1049	5	TRIM36	5	114472790	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	21548953	114472790	66442470	171	25446											
P4HA2	8974	broad.mit.edu	37	chr5	131533904	131533904	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acacatcatactcacgtagtTtaagaaagtagccacacgat	16	9	6	10	2	2	1	2	0	0	1	2	2	2	1	1	0	2	3	1	0	5	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:131533904T>A	uc003kwh.2	-	12	1930	c.1366A>T	c.(1366-1368)AAC>TAC	p.N456Y	P4HA2_uc003kwg.2_Intron|P4HA2_uc003kwi.2_Intron|P4HA2_uc003kwk.2_Intron|P4HA2_uc003kwl.2_Missense_Mutation_p.N456Y|P4HA2_uc003kwj.2_Intron	NM_004199	NP_004190	O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha II subunit isoform 1	456	Fe2OG dioxygenase.					endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding				0		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	CTCACGTAGTTTAAGAAAGTA	0.502													31	11					0	0	0	0	A	131533904	A	A	131533904	3	1	141	1	0	0	0	0	1	0	0	0	11411	1841	64	5	257	5	P4HA2	5	131533904	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	17061114	131533904	49381356	172	25447											
GFRA3	2676	broad.mit.edu	37	chr5	137593402	137593402	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaggcggcagcgcgcagttGggggcgatggtgttgcgccg	5	6	20	10	6	0	0	0	0	0	0	0	1	0	0	1	5	2	4	1	5	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:137593402G>T	uc003lcn.2	-	4	851	c.711C>A	c.(709-711)CCC>CCA	p.P237P	GFRA3_uc003lco.2_Silent_p.P206P	NM_001496	NP_001487	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3 preproprotein	237					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GCGCGCAGTTGGGGGCGATGG	0.711													16	6					3.52763e-06	3.91188e-06	1	0	T	137593402	T	T	137593402	2	4	141	1	0	0	0	0	0	0	0	1	6386	1335	47	4		4	GFRA3	5	137593402	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	6059498	137593402	43321858	173	25448											
NRG2	9542	broad.mit.edu	37	chr5	139231313	139231313	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccgggcctccacacatgctgGgctgttgcatttgctggtac	5	11	12	13	1	0	0	0	0	0	0	1	0	1	0	3	3	4	6	3	3	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:139231313G>T	uc003lex.1	-	9	1873	c.1648C>A	c.(1648-1650)CCA>ACA	p.P550T	NRG2_uc003lev.1_Missense_Mutation_p.P558T|NRG2_uc003lew.1_Missense_Mutation_p.P552T|NRG2_uc003ley.1_Missense_Mutation_p.P544T	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	550	Cytoplasmic (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACATGCTGGGCTGTTGCAT	0.627													7	25					0.00198382	0.00207142	1	0	T	139231313	T	T	139231313	3	4	141	1	0	0	0	0	1	0	0	0	10702	1232	43	4	912	4	NRG2	5	139231313	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1637911	139231313	41683947	174	25449											
PCDHA4	56144	broad.mit.edu	37	chr5	140188217	140188217	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgtgtctgcgtgggacgCggacgcgcaggagaacgcgc	7	5	17	12	7	1	1	0	0	1	1	1	4	1	3	0	3	2	1	0	3	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140188217C>A	uc003lhi.2	+	1	1546	c.1445C>A	c.(1444-1446)GCG>GAG	p.A482E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.A482E|PCDHA4_uc011daa.1_Missense_Mutation_p.A482E	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	482	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTGGGACGCGGACGCGCAG	0.657													36	28					1.71298e-08	2.0122e-08	1	0	A	140188217	A	A	140188217	3	1	141	1	0	0	0	0	1	0	0	0	11580	768	27	3	1447	3	PCDHA4	5	140188217	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	956904	140188217	40727043	175	25450											
PCDHA4	56144	broad.mit.edu	37	chr5	140188563	140188563	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggcaaaggtgcgcgcggtGgatgctgactcgggctacaa	8	7	17	9	4	0	1	0	1	0	0	1	2	0	2	0	5	3	3	0	5	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140188563G>A	uc003lhi.2	+	1	1892	c.1791G>A	c.(1789-1791)GTG>GTA	p.V597V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.V597V|PCDHA4_uc011daa.1_Silent_p.V597V	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	597	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGCGCGGTGGATGCTGACT	0.692													41	21					0	0	0	0	A	140188563	A	A	140188563	2	1	141	1	0	0	0	0	0	0	0	1	11580	1335	47	4		4	PCDHA4	5	140188563	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	346	140188563	40726697	176	25451											
PCDHA6	56142	broad.mit.edu	37	chr5	140209620	140209620	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctccgcgccaccggctgctGgtgctggtgaaagaccacgg	6	7	14	14	4	1	2	0	1	1	1	2	2	1	2	4	4	2	3	4	4	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140209620G>T	uc003lho.2	+	1	1971	c.1944G>T	c.(1942-1944)CTG>CTT	p.L648L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.L648L	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	648	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGGCTGCTGGTGCTGGTGA	0.667													37	16					3.6622e-26	5.46719e-26	1	0	T	140209620	T	T	140209620	2	4	141	1	0	0	0	0	0	0	0	1	11582	1335	47	4		4	PCDHA6	5	140209620	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	21057	140209620	40705640	177	25452											
PCDHA12	56137	broad.mit.edu	37	chr5	140257259	140257259	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accgtgagccggtgcgcgccGggcaagcccacgctggtgtg	5	5	17	14	6	0	1	0	1	0	0	0	1	0	1	4	3	3	2	4	3	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140257259G>T	uc003lic.2	+	1	2329	c.2202G>T	c.(2200-2202)CCG>CCT	p.P734P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.P734P	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	734	5 X 4 AA repeats of P-X-X-P.|Cytoplasmic (Potential).|PXXP 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCGCGCCGGGCAAGCCCA	0.682													13	2					4.36969e-10	5.30295e-10	1	0	T	140257259	T	T	140257259	2	4	141	1	0	0	0	0	0	0	0	1	11576	1103	39	3		3	PCDHA12	5	140257259	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	47639	140257259	40658001	178	25453											
PCDHGA1	56114	broad.mit.edu	37	chr5	140712446	140712446	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaggcttcgggaggcggctTagcgagcatgcccggttcgc	6	7	16	12	5	0	0	0	0	0	0	2	2	0	1	1	5	3	4	1	5	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140712446T>A	uc003lji.1	+	1	2195	c.2195T>A	c.(2194-2196)TTA>TAA	p.L732*	PCDHGA1_uc011dan.1_Nonsense_Mutation_p.L732*	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	732	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGGCGGCTTAGCGAGCATG	0.652													50	35					0	0	0	0	A	140712446	A	A	140712446	4	1	141	1	0	0	0	0	0	1	0	0	11604	1764	61	5	2197	5	PCDHGA1	5	140712446	Nonsense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	455187	140712446	40202814	179	25454											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720611	140720611	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacgattcggacctcactctGtacctggtggtggcggtggc	6	10	14	11	3	2	0	1	0	1	0	3	2	2	1	2	6	2	1	2	6	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140720611G>T	uc003ljk.1	+	1	2258	c.2073G>T	c.(2071-2073)CTG>CTT	p.L691L	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Silent_p.L691L|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	691	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTCACTCTGTACCTGGTGG	0.677													84	53					1.52804e-57	2.42961e-57	1	0	T	140720611	T	T	140720611	2	4	141	1	0	0	0	0	0	0	0	1	11608	1364	48	4		4	PCDHGA2	5	140720611	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	8165	140720611	40194649	180	25455											
PCDHGB6	56100	broad.mit.edu	37	chr5	140789266	140789267	+	Missense_Mutation	DNP	GG	TT	TT																															gcgagtgacctagagcccctGgcggtgtcgtcatacgtgtc																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140789266_140789267GG>TT	uc003lkj.1	+	1	1497_1498	c.1497_1498GG>TT	c.(1495-1500)CTGGCG>CTTTCG	p.A500S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.A500S	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	500	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGAGCCCCTGGCGGTGTCGTC	0.639													15	7					0	0	0	0	TT	140789267	TT	TT	140789266	3	4	141	1	0	0	0	0	1	0	0	0	11621	1335	47	4	1499	4	PCDHGB6	5	140789266	Missense_Mutation	DNP	GG	TCGA-CR-7370-01A-11D-2129-08	68655	140789266	40125994	181	25456											
PCDHGA12	26025	broad.mit.edu	37	chr5	140811002	140811002	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccggtgcgcacaggcaccGcgcgcatccgcgtgatggtt	6	6	14	15	7	0	1	0	1	0	0	1	1	1	1	3	3	1	4	3	3	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140811002G>A	uc003lkt.1	+	1	845	c.676G>A	c.(676-678)GCG>ACG	p.A226T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.A226T	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	226	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAGGCACCGCGCGCATCCG	0.657													33	12					0	0	0	0	A	140811002	A	A	140811002	3	1	141	1	0	0	0	0	1	0	0	0	11607	1087	38	1	678	1	PCDHGA12	5	140811002	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	21736	140811002	40104258	182	25457											
ZNF300	91975	broad.mit.edu	37	chr5	150275854	150275854	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccccagtatgagttctcTgatgtacaacaagatgaaac	13	11	7	10	0	2	4	0	3	2	1	4	4	2	4	2	0	3	3	2	0	5	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:150275854T>C	uc003lsy.1	-	6	1214	c.947A>G	c.(946-948)CAG>CGG	p.Q316R	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	316	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGAGTTCTCTGATGTACAAC	0.398													69	43					0	0	0	0	C	150275854	C	C	150275854	3	2	141	1	0	0	0	0	1	0	0	0	17898	1580	55	5	871	5	ZNF300	5	150275854	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	9464852	150275854	30639406	183	25458											
GRIA1	2890	broad.mit.edu	37	chr5	153077675	153077675	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagctgggggcgataattcAagtgttcagaacagaacata	15	8	11	7	1	2	2	2	0	0	2	2	3	2	2	0	2	3	2	0	2	6	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:153077675A>T	uc003lva.3	+	9	1571	c.1206A>T	c.(1204-1206)TCA>TCT	p.S402S	GRIA1_uc003luy.3_Silent_p.S402S|GRIA1_uc003luz.3_Silent_p.S307S|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Silent_p.S322S|GRIA1_uc011dcx.1_Silent_p.S333S|GRIA1_uc011dcy.1_Silent_p.S412S|GRIA1_uc011dcz.1_Silent_p.S412S|GRIA1_uc010jia.1_Silent_p.S382S	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	402	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GCGATAATTCAAGTGTTCAGA	0.458													16	15					0	0	0	0	T	153077675	T	T	153077675	2	4	141	1	0	0	0	0	0	0	0	1	6806	117	5	5		5	GRIA1	5	153077675	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	2801821	153077675	27837585	184	25459											
SGCD	6444	broad.mit.edu	37	chr5	156184595	156184595	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttgggtgtttttcaggttGgagtccccaacccggtctct	4	15	11	11	1	3	0	1	0	2	0	5	1	4	1	3	4	1	2	3	4	1	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:156184595G>T	uc003lwd.3	+	7	1052	c.576G>T	c.(574-576)TTG>TTT	p.L192F	SGCD_uc003lwb.2_Missense_Mutation_p.L193F|SGCD_uc003lwc.3_Missense_Mutation_p.L193F	NM_001128209	NP_001121681	Q92629	SGCD_HUMAN	delta-sarcoglycan isoform 3	192	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTTCAGGTTGGAGTCCCCAA	0.443													9	2					2.80697e-09	3.34012e-09	1	0	T	156184595	T	T	156184595	3	4	141	1	0	0	0	0	1	0	0	0	14266	1339	47	4	605	4	SGCD	5	156184595	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3106920	156184595	24730665	185	25460											
C5orf54	63920	broad.mit.edu	37	chr5	159821207	159821207	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgaaacaattatttcttCaagaaaaggaaaattggtaa	19	12	6	4	0	3	2	1	1	2	1	3	3	3	3	0	2	1	1	0	2	9	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:159821207C>A	uc003lye.1	-	2	1755	c.1291G>T	c.(1291-1293)GAA>TAA	p.E431*	C5orf54_uc003lyf.1_Nonsense_Mutation_p.E431*	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	431										pancreas(1)	1						attatttcttcaagaaaagga	0													38	20					1.414e-09	1.69634e-09	1	0	A	159821207	A	A	159821207	4	1	141	1	0	0	0	0	0	1	0	0	2320	835	29	2	497	2	C5orf54	5	159821207	Nonsense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3636612	159821207	21094053	186	25461											
ATP10B	23120	broad.mit.edu	37	chr5	160029629	160029629	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accatcctggccaggcgcgaGtaacaccagtggccatgcac	10	5	11	15	2	0	0	0	0	0	0	1	1	1	0	5	3	2	2	5	3	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:160029629G>A	uc003lym.1	-	21	4165	c.3318C>T	c.(3316-3318)TAC>TAT	p.Y1106Y	ATP10B_uc010jit.1_Silent_p.Y423Y	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1106	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCAGGCGCGAGTAACACCAGT	0.567													22	10					0	0	0	0	A	160029629	A	A	160029629	2	1	141	1	0	0	0	0	0	0	0	1	1119	1024	36	4		4	ATP10B	5	160029629	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	208422	160029629	20885631	187	25462											
ATP10B	23120	broad.mit.edu	37	chr5	160033898	160033898	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caattccagaaacttcttctCtagctttccctggaagatgg	10	13	7	11	0	2	2	0	0	2	2	5	3	4	3	2	2	2	1	2	2	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:160033898C>A	uc003lym.1	-	19	3881	c.3034G>T	c.(3034-3036)GAG>TAG	p.E1012*	ATP10B_uc010jit.1_Nonsense_Mutation_p.E329*	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1012	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AACTTCTTCTCTAGCTTTCCC	0.507													51	40					4.86159e-25	7.18457e-25	1	0	A	160033898	A	A	160033898	4	1	141	1	0	0	0	0	0	1	0	0	1119	922	32	2	1383	2	ATP10B	5	160033898	Nonsense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4269	160033898	20881362	188	25463											
ODZ2	57451	broad.mit.edu	37	chr5	167655022	167655022	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcaccatcacccccaccAttggacgctgcaacatctcc	9	6	7	19	2	2	0	1	0	1	0	3	1	2	1	5	2	2	3	5	2	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:167655022A>G	uc010jjd.2	+	25	5380	c.5380A>G	c.(5380-5382)ATT>GTT	p.I1794V	ODZ2_uc003lzr.3_Missense_Mutation_p.I1564V|ODZ2_uc003lzt.3_Missense_Mutation_p.I1167V|ODZ2_uc010jje.2_Missense_Mutation_p.I1058V	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CACCCCCACCATTGGACGCTG	0.512													14	5					0	0	0	0	G	167655022	G	G	167655022	3	3	141	1	0	0	0	0	1	0	0	0	10889	217	8	5	5478	5	ODZ2	5	167655022	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	7621124	167655022	13260238	189	25464											
HK3	3101	broad.mit.edu	37	chr5	176318482	176318482	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcgcctgctccatggaacCcaagaggctggcttggatct	8	8	12	13	1	1	1	0	0	1	1	2	3	2	3	3	4	3	3	3	4	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:176318482C>G	uc003mfa.2	-	3	258	c.166G>C	c.(166-168)GGT>CGT	p.G56R	HK3_uc003mez.2_5'Flank	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	56	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCATGGAACCCAAGAGGCTG	0.627													30	28					0	0	0	0	G	176318482	G	G	176318482	3	3	141	1	0	0	0	0	1	0	0	0	7231	623	22	4	2673	4	HK3	5	176318482	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	8663460	176318482	4596778	190	25465											
ZNF346	23567	broad.mit.edu	37	chr5	176489129	176489129	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacagtaccaagctcatgtCagcggcttcaaacacaagaa	16	6	8	11	1	3	1	3	0	0	1	3	2	3	1	1	1	5	3	1	1	6	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:176489129C>T	uc003mfi.2	+	6	817	c.774C>T	c.(772-774)GTC>GTT	p.V258V	ZNF346_uc011dfr.1_Silent_p.V226V|ZNF346_uc011dfs.1_Silent_p.V160V|ZNF346_uc003mfj.2_Silent_p.V82V|ZNF346_uc003mfk.1_Silent_p.V283V|ZNF346_uc011dft.1_Silent_p.V82V	NM_012279	NP_036411	Q9UL40	ZN346_HUMAN	zinc finger protein 346	258	Matrin-type 4.					cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding				0	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGCTCATGTCAGCGGCTTCA	0.408													66	48					0	0	0	0	T	176489129	T	T	176489129	2	4	141	1	0	0	0	0	0	0	0	1	17927	813	29	2		2	ZNF346	5	176489129	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	170647	176489129	4426131	191	25466											
ADAMTS2	9509	broad.mit.edu	37	chr5	178770807	178770807	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcgccacagaggaggcttcGgctaggccggccacgtctcc	7	5	14	15	4	1	1	0	0	1	1	3	2	1	2	4	5	1	2	4	5	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:178770807G>A	uc003mjw.2	-	2	495	c.495C>T	c.(493-495)GCC>GCT	p.A165A	ADAMTS2_uc011dgm.1_Silent_p.A165A	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	165					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		AGGAGGCTTCGGCTAGGCCGG	0.652													6	8					0	0	0	0	A	178770807	A	A	178770807	2	1	141	1	0	0	0	0	0	0	0	1	265	1103	39	1		1	ADAMTS2	5	178770807	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2281678	178770807	2144453	192	25467											
JARID2	3720	broad.mit.edu	37	chr6	15468903	15468903	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcatcttcatgccagtcGacccccaggaaaggaaaaac	13	7	8	13	1	3	0	2	0	1	0	4	3	3	2	3	2	2	1	3	2	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:15468903G>T	uc003nbj.2	+	5	868	c.624G>T	c.(622-624)TCG>TCT	p.S208S	JARID2_uc011diu.1_Silent_p.S72S|JARID2_uc011div.1_Silent_p.S36S|JARID2_uc011diw.1_Silent_p.S170S	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	208					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CATGCCAGTCGACCCCCAGGA	0.468													37	57					3.71624e-46	5.83298e-46	1	0	T	15468903	T	T	15468903	2	4	141	1	0	0	0	0	0	0	0	1	7984	1045	37	3		3	JARID2	6	15468903	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08		15468903	155646164	193	25468											
OR2B6	26212	broad.mit.edu	37	chr6	27925284	27925284	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtaaatttatgcagcatcaGgaaagtaatcagttatcgtg	15	12	9	5	1	2	0	2	0	0	0	3	1	2	1	0	1	2	5	0	1	6	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:27925284G>A	uc011dkx.1	+	1	266	c.266G>A	c.(265-267)AGG>AAG	p.R89K		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGCAGCATCAGGAAAGTAATC	0.428													30	16					0	0	0	0	A	27925284	A	A	27925284	3	1	141	1	0	0	0	0	1	0	0	0	11045	1000	35	4	268	4	OR2B6	6	27925284	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	12456381	27925284	143189783	194	25469											
COL11A2	1302	broad.mit.edu	37	chr6	33146751	33146751	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcagcacctgcccggccCtgggagaacaagggaagtgt	10	5	13	13	1	1	1	1	0	0	1	1	3	1	2	4	3	3	1	4	3	3	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:33146751C>A	uc003ocx.1	-	17	1840	c.1612_splice	c.e17-1	p.G538_splice	COL11A2_uc010jul.1_5'Flank|COL11A2_uc003ocy.1_Splice_Site_p.G452_splice|COL11A2_uc003ocz.1_Splice_Site_p.G431_splice	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1						cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CTGCCCGGCCCTGGGAGAACA	0.647													16	11					0.00400662	0.00415397	1	0	A	33146751	A	A	33146751	5	1	141	1	0	0	0	0	0	0	1	0	3683	695	24	4	3799	4	COL11A2	6	33146751	Splice_Site	SNP	C	TCGA-CR-7370-01A-11D-2129-08	5221467	33146751	137968316	195	25470											
RGL2	5863	broad.mit.edu	37	chr6	33264212	33264212	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttgtcctctctagttcgTcggtaggatgagattcaagg	7	14	12	8	2	2	1	1	1	1	1	6	3	3	2	1	3	0	3	1	3	3	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:33264212T>C	uc003odv.2	-	5	582	c.449A>G	c.(448-450)GAC>GGC	p.D150G	RGL2_uc003odu.2_5'Flank|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_Missense_Mutation_p.D68G|RGL2_uc011drb.1_Missense_Mutation_p.D68G	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	150	N-terminal Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						CTCTAGTTCGTCGGTAGGATG	0.522													33	18					0	0	0	0	C	33264212	C	C	33264212	3	2	141	1	0	0	0	0	1	0	0	0	13342	1667	58	5	1940	5	RGL2	6	33264212	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	117461	33264212	137850855	196	25471											
LRFN2	57497	broad.mit.edu	37	chr6	40399511	40399511	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagctggtacatcttcacccGgggtgctgacttgctgacag	7	10	12	12	1	2	2	1	2	1	0	2	2	2	2	1	3	4	4	1	3	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:40399511G>A	uc003oph.1	-	2	1807	c.1342C>T	c.(1342-1344)CGG>TGG	p.R448W		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	448	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					ATCTTCACCCGGGGTGCTGAC	0.592													11	37					0	0	0	0	A	40399511	A	A	40399511	3	1	141	1	0	0	0	0	1	0	0	0	8988	1115	39	1	1035	1	LRFN2	6	40399511	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	7135299	40399511	130715556	197	25472											
TFEB	7942	broad.mit.edu	37	chr6	41653831	41653831	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caagttcaggaccagacctgGatacggagccagagctgctt	11	7	12	11	1	1	2	1	0	0	2	1	5	1	5	3	3	4	3	3	3	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:41653831G>T	uc003oqs.1	-	9	1250	c.948C>A	c.(946-948)ATC>ATA	p.I316I	TFEB_uc003oqt.1_Silent_p.I316I|TFEB_uc003oqu.1_Silent_p.I330I|TFEB_uc003oqr.1_Silent_p.I231I	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	316	Leucine-zipper.				embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			ACCAGACCTGGATACGGAGCC	0.537			T	ALPHA	renal (childhood epithelioid)								15	61					3.41278e-10	4.14854e-10	1	0	T	41653831	T	T	41653831	2	4	141	1	0	0	0	0	0	0	0	1	15867	1164	41	2		2	TFEB	6	41653831	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1254320	41653831	129461236	198	25473											
CUL7	9820	broad.mit.edu	37	chr6	43020081	43020081	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctccagtgaggggctcaatgCtggcataggcgctgagcacg	8	7	15	11	2	1	2	1	2	0	0	2	2	2	2	1	4	2	5	1	4	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:43020081C>T	uc003otq.2	-	2	749	c.446G>A	c.(445-447)AGC>AAC	p.S149N	CUL7_uc011dvb.1_Missense_Mutation_p.S201N|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	149					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GGGCTCAATGCTGGCATAGGC	0.557													4	35					0	0	0	0	T	43020081	T	T	43020081	3	4	141	1	0	0	0	0	1	0	0	0	4077	797	28	4	4846	4	CUL7	6	43020081	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1366250	43020081	128094986	199	25474											
PTK7	5754	broad.mit.edu	37	chr6	43109969	43109969	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgtggcccctgaggactcagGccgctacacctgcattgcag	7	7	12	15	2	1	1	1	1	0	0	1	2	1	2	4	3	3	3	4	3	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:43109969G>T	uc003oub.1	+	13	2177	c.1979G>T	c.(1978-1980)GGC>GTC	p.G660V	PTK7_uc003ouc.1_Intron|PTK7_uc003oud.1_Missense_Mutation_p.G620V|PTK7_uc003oue.1_Missense_Mutation_p.G530V|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Missense_Mutation_p.G668V|PTK7_uc010jyj.1_Intron	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	660	Ig-like C2-type 7.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GAGGACTCAGGCCGCTACACC	0.607													27	40					4.74835e-14	6.21526e-14	1	0	T	43109969	T	T	43109969	3	4	141	1	0	0	0	0	1	0	0	0	12828	1203	42	4	2029	4	PTK7	6	43109969	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	89888	43109969	128005098	200	25475											
TINAG	27283	broad.mit.edu	37	chr6	54191661	54191661	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagaagatggttttaaatttCgccttggcactttgccacct	9	15	8	9	1	0	2	0	0	0	2	1	2	0	2	3	2	1	2	3	2	4	6	rs115438249	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:54191661C>T	uc003pcj.2	+	4	717	c.571C>T	c.(571-573)CGC>TGC	p.R191C	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	191					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TTTTAAATTTCGCCTTGGCAC	0.373													26	38					0	0	0	0	T	54191661	T	T	54191661	3	4	141	1	0	0	0	0	1	0	0	0	15987	884	31	1	585	1	TINAG	6	54191661	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	11081692	54191661	116923406	201	25476											
TINAG	27283	broad.mit.edu	37	chr6	54214671	54214671	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acaggatctatcaatgttctCctccatacagagtctcttcc	10	13	5	13	0	4	1	1	0	3	1	8	2	6	2	3	1	1	1	3	1	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:54214671C>A	uc003pcj.2	+	7	1203	c.1057C>A	c.(1057-1059)CCT>ACT	p.P353T	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	353					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TCAATGTTCTCCTCCATACAG	0.408													11	51					7.93312e-07	8.91868e-07	1	0	A	54214671	A	A	54214671	3	1	141	1	0	0	0	0	1	0	0	0	15987	855	30	2	1083	2	TINAG	6	54214671	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	23010	54214671	116900396	202	25477											
PRIM2	5558	broad.mit.edu	37	chr6	57512611	57512611	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caaaccaagtgtccagaaaaCcaaggatgcatcatctgctc	15	7	7	12	0	2	1	1	0	1	1	4	2	3	2	3	1	4	2	3	1	5	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:57512611C>T	uc003pdx.2	+	15	1526	c.1439C>T	c.(1438-1440)ACC>ATC	p.T480I		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	480					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		GTCCAGAAAACCAAGGATGCA	0.403													60	373					0	0	0	0	T	57512611	T	T	57512611	3	4	141	1	0	0	0	0	1	0	0	0	12553	507	18	4	1489	4	PRIM2	6	57512611	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3297940	57512611	113602456	203	25478											
DDX43	55510	broad.mit.edu	37	chr6	74116174	74116174	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agacattgtgttatttaatgCctggatttattcatctggtc	9	18	8	6	0	2	1	1	0	1	1	3	2	2	2	1	2	1	1	1	2	3	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:74116174C>A	uc003pgw.2	+	7	1239	c.895C>A	c.(895-897)CCT>ACT	p.P299T	DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	299	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						TTATTTAATGCCTGGATTTAT	0.378													23	20					9.57634e-11	1.18173e-10	1	0	A	74116174	A	A	74116174	3	1	141	1	0	0	0	0	1	0	0	0	4380	739	26	4	921	4	DDX43	6	74116174	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	16603563	74116174	96998893	204	25479											
FUT9	10690	broad.mit.edu	37	chr6	96651708	96651708	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaagcatttggagaatatgTcaatgataaaaatttgattc	16	13	8	4	0	1	3	1	2	0	1	2	4	1	3	0	1	1	2	0	1	7	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:96651708T>A	uc003pop.3	+	3	1018	c.677T>A	c.(676-678)GTC>GAC	p.V226D		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	226	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GGAGAATATGTCAATGATAAA	0.353													8	20					0	0	0	0	A	96651708	A	A	96651708	3	1	141	1	0	0	0	0	1	0	0	0	6145	1667	58	5	679	5	FUT9	6	96651708	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	22535534	96651708	74463359	205	25480											
LIN28B	389421	broad.mit.edu	37	chr6	105406156	105406156	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttccagtcgatgtatttgtaCaccaagtaagccaaactttt	12	14	6	9	1	0	0	0	0	0	0	2	1	1	0	3	0	3	3	3	0	5	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:105406156C>G	uc003pqv.1	+	2	396	c.193C>G	c.(193-195)CAC>GAC	p.H65D	LIN28B_uc010kda.1_Missense_Mutation_p.H25D	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	65	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				TGTATTTGTACACCAAGTAAG	0.453													36	56					0	0	0	0	G	105406156	G	G	105406156	3	3	141	1	0	0	0	0	1	0	0	0	8848	478	17	4	199	4	LIN28B	6	105406156	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	8754448	105406156	65708911	206	25481											
C6orf203	51250	broad.mit.edu	37	chr6	107361208	107361208	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatgtatttttcctttttccGtaagactcaaaagtaatata	14	17	4	6	1	1	1	1	0	0	1	3	1	3	1	2	0	0	3	2	0	8	9	rs150832095	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:107361208G>A	uc003prq.2	+	2	325	c.244G>A	c.(244-246)GTA>ATA	p.V82I	C6orf203_uc011eaj.1_Missense_Mutation_p.V87I|C6orf203_uc010kde.2_Missense_Mutation_p.V82I	NM_016487	NP_057571	Q9P0P8	CF203_HUMAN	hypothetical protein LOC51250 isoform a	82											0	Breast(9;0.00124)|all_epithelial(6;0.0729)	all_cancers(87;0.00461)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|Colorectal(196;0.171)|all_epithelial(87;0.23)	BRCA - Breast invasive adenocarcinoma(8;0.000395)|all cancers(7;0.00065)|Epithelial(6;0.000834)|OV - Ovarian serous cystadenocarcinoma(5;0.244)	BRCA - Breast invasive adenocarcinoma(108;0.117)		TCCTTTTTCCGTAAGACTCAA	0.333													25	55					0	0	0	0	A	107361208	A	A	107361208	3	1	141	1	0	0	0	0	1	0	0	0	2362	1145	40	1	265	1	C6orf203	6	107361208	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1955052	107361208	63753859	207	25482											
GPR6	2830	broad.mit.edu	37	chr6	110301114	110301114	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgctgcagcagcactgcctgGcgccaccccatctcgctgcc	5	6	10	20	3	1	0	0	0	1	0	2	0	1	0	5	1	5	5	5	1	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:110301114G>T	uc011eaw.1	+	2	979	c.799G>T	c.(799-801)GCG>TCG	p.A267S	GPR6_uc011eav.1_Missense_Mutation_p.A282S|GPR6_uc003ptu.2_Missense_Mutation_p.A267S	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	267	Cytoplasmic (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		GCACTGCCTGGCGCCACCCCA	0.637													7	37					5.4927e-09	6.48334e-09	1	0	T	110301114	T	T	110301114	3	4	141	1	0	0	0	0	1	0	0	0	6739	1203	42	4	801	4	GPR6	6	110301114	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2939906	110301114	60813953	208	25483											
GPRC6A	222545	broad.mit.edu	37	chr6	117130668	117130668	+	Frame_Shift_Del	DEL	A	-	-																															tgccactgtgacttctgtacAagtgtcatagatttcatacc																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:117130668delA	uc003pxj.1	-	2	329	c.307delT	c.(307-309)TGTfs	p.C103fs	GPRC6A_uc003pxk.1_Frame_Shift_Del_p.C103fs|GPRC6A_uc003pxl.1_Frame_Shift_Del_p.C103fs	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	103	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ACTTCTGTACAAGTGTCATAG	0.408													---	---	---								-	117130668	-	-	117130668	7	5	141	1	0	1	0	1	0	0	0	0	6767	130	5	0	2493	0	GPRC6A	6	117130668	Frame_Shift_Del	DEL	A	TCGA-CR-7370-01A-11D-2129-08	6829554	117130668	53984399	209	25484											
ROS1	6098	broad.mit.edu	37	chr6	117665282	117665282	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attaacttctgcataataaaCcaggtatgttggagtagggc	13	12	10	6	0	1	0	0	0	1	0	1	1	1	1	1	3	3	4	1	3	6	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:117665282C>A	uc003pxp.1	-	27	4664	c.4465G>T	c.(4465-4467)GTT>TTT	p.V1489F	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1489	Extracellular (Potential).|Fibronectin type-III 6.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCATAATAAACCAGGTATGTT	0.398			T	GOPC|ROS1	glioblastoma|NSCLC								17	32					5.35267e-07	6.04546e-07	1	0	A	117665282	A	A	117665282	3	1	141	1	0	0	0	0	1	0	0	0	13596	507	18	4	2646	4	ROS1	6	117665282	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	534614	117665282	53449785	210	25485											
LAMA2	3908	broad.mit.edu	37	chr6	129704301	129704301	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcagatggcgagcagaccgGacaggatgctgagaggacca	13	3	16	9	2	0	3	0	1	0	3	0	8	0	6	2	4	3	3	2	4	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:129704301G>T	uc003qbn.2	+	35	5099	c.4994G>T	c.(4993-4995)GGA>GTA	p.G1665V	LAMA2_uc003qbo.2_Missense_Mutation_p.G1665V	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1665	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAGCAGACCGGACAGGATGCT	0.448													10	17					0.000978159	0.00102574	1	0	T	129704301	T	T	129704301	3	4	141	1	0	0	0	0	1	0	0	0	8646	1174	41	2	5132	2	LAMA2	6	129704301	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	12039019	129704301	41410766	211	25486											
MOXD1	26002	broad.mit.edu	37	chr6	132722446	132722446	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctgccccgctggctccaGcccagccagtacttgccctc	4	8	10	19	1	0	0	0	0	0	0	2	0	1	0	6	2	5	4	6	2	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:132722446G>T	uc003qdf.2	-	1	219	c.120C>A	c.(118-120)GGC>GGA	p.G40G		NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	40	Lumenal (Potential).|DOMON.				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		GCTGGCTCCAGCCCAGCCAGT	0.736													6	7					1.06961e-07	1.22696e-07	1	0	T	132722446	T	T	132722446	2	4	141	1	0	0	0	0	0	0	0	1	9773	958	34	4		4	MOXD1	6	132722446	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3018145	132722446	38392621	212	25487											
TAAR2	9287	broad.mit.edu	37	chr6	132938351	132938351	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgagctgaaaattttacCtagcaaaatgtacttcagtg	15	12	7	7	0	1	2	1	2	0	0	1	2	1	2	1	0	4	3	1	0	7	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:132938351C>T	uc003qdl.1	-	2	994	c.994G>A	c.(994-996)GGT>AGT	p.G332S	TAAR2_uc010kfr.1_Missense_Mutation_p.G287S	NM_001033080	NP_001028252	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2 isoform 1	332	Cytoplasmic (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		AAAATTTTACCTAGCAAAATG	0.343													23	20					0	0	0	0	T	132938351	T	T	132938351	3	4	141	1	0	0	0	0	1	0	0	0	15556	681	24	4	65	4	TAAR2	6	132938351	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	215905	132938351	38176716	213	25488											
VNN2	8875	broad.mit.edu	37	chr6	133073775	133073775	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagggtaacaccaggatcAtagaagaatatatcaaagca	19	6	8	8	0	2	2	2	0	0	2	2	3	2	3	2	2	2	2	2	2	7	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:133073775A>G	uc003qdt.2	-	4	662	c.651T>C	c.(649-651)TAT>TAC	p.Y217Y	VNN2_uc003qds.2_Intron|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Silent_p.Y164Y	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	217	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CACCAGGATCATAGAAGAATA	0.443													42	95					0	0	0	0	G	133073775	G	G	133073775	2	3	141	1	0	0	0	0	0	0	0	1	17251	224	8	5		5	VNN2	6	133073775	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	135424	133073775	38041292	214	25489											
ALDH8A1	64577	broad.mit.edu	37	chr6	135239568	135239568	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagatcagtgtttaacggtGatggttttgatctcagtgaa	12	14	11	4	1	2	4	2	3	1	1	3	4	2	4	0	2	1	2	0	2	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:135239568G>T	uc003qew.2	-	7	1502	c.1449C>A	c.(1447-1449)ATC>ATA	p.I483I	ALDH8A1_uc003qex.2_Silent_p.I429I|ALDH8A1_uc010kgh.2_Silent_p.I261I|ALDH8A1_uc011ecx.1_Silent_p.I433I	NM_022568	NP_072090	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8A1 isoform 1	483					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		GTTTAACGGTGATGGTTTTGA	0.478													13	30					1.49906e-05	1.63757e-05	1	0	T	135239568	T	T	135239568	2	4	141	1	0	0	0	0	0	0	0	1	505	1280	45	2		2	ALDH8A1	6	135239568	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2165793	135239568	35875499	215	25490											
OLIG3	167826	broad.mit.edu	37	chr6	137814953	137814953	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcgatcttggagagcttgcGcaccgacggcccatgcgcgt	6	7	15	13	6	1	1	0	0	1	1	1	4	1	1	2	3	3	2	2	3	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:137814953G>C	uc003qhp.1	-	1	579	c.355C>G	c.(355-357)CGC>GGC	p.R119G		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	119	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		GAGAGCTTGCGCACCGACGGC	0.602													17	50					0	0	0	0	C	137814953	C	C	137814953	3	2	141	1	0	0	0	0	1	0	0	0	10916	1087	38	3	467	3	OLIG3	6	137814953	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2575385	137814953	33300114	216	25491											
ULBP1	80329	broad.mit.edu	37	chr6	150290448	150290448	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgggggattgtaagatgTggcttgaagaatttttgatg	10	14	14	3	0	0	4	0	2	0	2	0	5	0	5	0	3	0	2	0	3	3	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:150290448T>C	uc003qnp.2	+	3	620	c.577T>C	c.(577-579)TGG>CGG	p.W193R		NM_025218	NP_079494	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1 precursor	193	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			pancreas(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		TTGTAAGATGTGGCTTGAAGA	0.448													52	65					0	0	0	0	C	150290448	C	C	150290448	3	2	141	1	0	0	0	0	1	0	0	0	17040	1696	59	5	587	5	ULBP1	6	150290448	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	12475495	150290448	20824619	217	25492											
SYNE1	23345	broad.mit.edu	37	chr6	152652521	152652521	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtcactgagacaattcacGtggctttgtgcatcagagag	12	10	11	8	1	3	2	3	1	0	2	3	4	3	2	0	1	1	2	0	1	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:152652521G>T	uc010kiw.2	-	78	13901	c.13299C>A	c.(13297-13299)CAC>CAA	p.H4433Q	SYNE1_uc003qot.3_Missense_Mutation_p.H4362Q|SYNE1_uc003qou.3_Missense_Mutation_p.H4433Q|SYNE1_uc010kiz.2_Missense_Mutation_p.H188Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4433	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACAATTCACGTGGCTTTGTG	0.493										HNSCC(10;0.0054)			35	29					9.80977e-26	1.45853e-25	1	0	T	152652521	T	T	152652521	3	4	141	1	0	0	0	0	1	0	0	0	15511	1136	40	3	13443	3	SYNE1	6	152652521	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2362073	152652521	18462546	218	25493											
RGS17	26575	broad.mit.edu	37	chr6	153347653	153347653	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtcttcccgcattttcccCtctttcttcattcctcacag	4	16	5	16	1	5	0	2	0	3	0	8	0	8	0	4	1	0	1	4	1	0	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:153347653C>A	uc003qpm.2	-	3	301	c.145G>T	c.(145-147)GGG>TGG	p.G49W		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	49					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		GCATTTTCCCCTCTTTCTTCA	0.398									Lung_Cancer_Familial_Clustering_of				23	89					1.75199e-13	2.26891e-13	1	0	A	153347653	A	A	153347653	3	1	141	1	0	0	0	0	1	0	0	0	13364	681	24	4	499	4	RGS17	6	153347653	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	695132	153347653	17767414	219	25494											
SYNJ2	8871	broad.mit.edu	37	chr6	158454617	158454617	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaggccaaggcctgcctcGtctctcgcgttagctgtgag	6	9	13	13	3	1	1	0	1	1	0	4	1	1	1	3	2	3	3	3	2	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:158454617G>T	uc003qqx.1	+	4	691	c.616G>T	c.(616-618)GTC>TTC	p.V206F	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Missense_Mutation_p.V206F|SYNJ2_uc003qqy.1_5'UTR|SYNJ2_uc011efn.1_Missense_Mutation_p.V155F|SYNJ2_uc010kjo.1_Missense_Mutation_p.V155F	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	206	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		GGCCTGCCTCGTCTCTCGCGT	0.622													23	32					4.72057e-08	5.4577e-08	1	0	T	158454617	T	T	158454617	3	4	141	1	0	0	0	0	1	0	0	0	15519	1145	40	3	630	3	SYNJ2	6	158454617	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	5106964	158454617	12660450	220	25495											
PDE10A	10846	broad.mit.edu	37	chr6	165752772	165752772	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaataattcatacctggcCttgggggacttcatccttct	8	16	7	10	0	3	0	2	0	1	0	4	1	4	1	3	3	1	0	3	3	3	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:165752772C>A	uc003qun.2	-	21	2384	c.2143G>T	c.(2143-2145)GGC>TGC	p.G715C	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.G645C|PDE10A_uc003quo.2_Missense_Mutation_p.G725C	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	715					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CATACCTGGCCTTGGGGGACT	0.353													23	92					5.35356e-11	6.63986e-11	1	0	A	165752772	A	A	165752772	3	1	141	1	0	0	0	0	1	0	0	0	11684	681	24	4	208	4	PDE10A	6	165752772	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	7298155	165752772	5362295	221	25496											
T	6862	broad.mit.edu	37	chr6	166581041	166581041	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtggtccactcggtactgCaggctctttcccgcgctctc	4	11	11	15	3	2	0	0	0	2	0	6	0	4	0	2	4	2	4	2	4	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:166581041C>G	uc003quu.1	-	2	532	c.39G>C	c.(37-39)CTG>CTC	p.L13L	T_uc003qut.1_Silent_p.L13L|T_uc003quv.1_Silent_p.L13L	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	13					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		CTCGGTACTGCAGGCTCTTTC	0.697									Chordoma_Familial_Clustering_of				5	8					0	0	0	0	G	166581041	G	G	166581041	2	3	141	1	0	0	0	0	0	0	0	1	15554	697	25	4		4	T	6	166581041	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	828269	166581041	4534026	222	25497											
FRMD1	79981	broad.mit.edu	37	chr6	168457935	168457935	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctgagtgaggtgggcgctgGgtgcagggccagctggtgca	5	7	21	8	1	0	2	0	2	0	0	0	2	0	2	1	5	3	5	1	5	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:168457935G>T	uc003qwo.3	-	11	1557	c.1492C>A	c.(1492-1494)CCA>ACA	p.P498T	FRMD1_uc003qwm.3_Missense_Mutation_p.P292T|FRMD1_uc011egs.1_Missense_Mutation_p.P269T|FRMD1_uc011egt.1_Missense_Mutation_p.P433T|FRMD1_uc003qwn.3_Missense_Mutation_p.P430T	NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	498						cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GTGGGCGCTGGGTGCAGGGCC	0.672													8	3					5.18039e-06	5.71872e-06	1	0	T	168457935	T	T	168457935	3	4	141	1	0	0	0	0	1	0	0	0	6083	1232	43	4	161	4	FRMD1	6	168457935	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1876894	168457935	2657132	223	25498											
FRMD1	79981	broad.mit.edu	37	chr6	168464370	168464370	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcctccttggggctcaggcCctggcgctcacggtgcaggg	3	7	17	14	2	2	0	2	0	0	0	3	0	3	0	3	7	1	3	3	7	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:168464370C>A	uc003qwo.3	-	6	780	c.715G>T	c.(715-717)GGC>TGC	p.G239C	FRMD1_uc003qwm.3_Missense_Mutation_p.G10C|FRMD1_uc011egs.1_Missense_Mutation_p.G10C|FRMD1_uc011egt.1_Missense_Mutation_p.G151C|FRMD1_uc003qwn.3_Missense_Mutation_p.G171C	NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	239	FERM.					cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GGGCTCAGGCCCTGGCGCTCA	0.642													15	31					1.02788e-11	1.29457e-11	1	0	A	168464370	A	A	168464370	3	1	141	1	0	0	0	0	1	0	0	0	6083	623	22	4	958	4	FRMD1	6	168464370	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	6435	168464370	2650697	224	25499											
DNAH11	8701	broad.mit.edu	37	chr7	21747362	21747362	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atgttaacatgaaacagaagCcggtttggaatgacttaaac	16	10	9	6	1	0	3	0	2	0	1	0	4	0	4	1	2	4	2	1	2	6	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:21747362C>T	uc003svc.2	+	41	6644	c.6613C>T	c.(6613-6615)CCG>TCG	p.P2205S		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2205	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GAAACAGAAGCCGGTTTGGAA	0.383									Kartagener_syndrome				13	25					0	0	0	0	T	21747362	T	T	21747362	3	4	141	1	0	0	0	0	1	0	0	0	4621	739	26	4	6772	4	DNAH11	7	21747362	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08		21747362	137391301	225	25500											
CCDC126	90693	broad.mit.edu	37	chr7	23682551	23682551	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgatttattcccctagcGgatctgaaaagaacaattgc	12	13	7	9	1	2	3	0	2	2	1	3	4	3	4	2	1	3	0	2	1	6	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:23682551G>T	uc003swl.2	+	4	697	c.240G>T	c.(238-240)GCG>GCT	p.A80A	CCDC126_uc003swm.2_Silent_p.A80A|CCDC126_uc003swn.2_Silent_p.A80A	NM_138771	NP_620126	Q96EE4	CC126_HUMAN	coiled-coil domain containing 126 precursor	80						extracellular region				ovary(1)|skin(1)	2						TTCCCCTAGCGGATCTGAAAA	0.368													25	35					3.7963e-18	5.19159e-18	1	0	T	23682551	T	T	23682551	2	4	141	1	0	0	0	0	0	0	0	1	2774	1130	39	3		3	CCDC126	7	23682551	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1935189	23682551	135456112	226	25501											
LOC402644	402644	broad.mit.edu	37	chr7	28318964	28318964	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttgccatccaaccacccCgtcttggcagtgcagatgaa	9	9	9	14	1	1	2	0	1	1	1	2	2	2	2	5	1	4	3	5	1	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:28318964C>A	uc010kuz.1	-	1	355	c.355G>T	c.(355-357)GGG>TGG	p.G119W		NM_001126493	NP_001119965			hypothetical protein LOC402644												0						CCAACCACCCCGTCTTGGCAG	0.468													19	30					1.96292e-10	2.40204e-10	1	0	A	28318964	A	A	28318964	3	1	141	1	0	0	0	0	1	0	0	0	8927	652	23	3	125	3	LOC402644	7	28318964	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4636413	28318964	130819699	227	25502											
PDE1C	5137	broad.mit.edu	37	chr7	31864484	31864484	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caagcttccccactgacctcGaacgcctctgtcctgtccca	7	9	6	19	2	1	1	0	1	1	0	5	2	4	1	6	0	2	1	6	0	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:31864484G>C	uc003tcm.1	-	13	1872	c.1403C>G	c.(1402-1404)TCG>TGG	p.S468W	PDE1C_uc003tcn.1_Missense_Mutation_p.S468W|PDE1C_uc003tco.1_Missense_Mutation_p.S528W|PDE1C_uc003tcr.2_Missense_Mutation_p.S468W|PDE1C_uc003tcs.2_Missense_Mutation_p.S468W	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	468	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.S468S(1)		skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CACTGACCTCGAACGCCTCTG	0.512													42	94					0	0	0	0	C	31864484	C	C	31864484	3	2	141	1	0	0	0	0	1	0	0	0	11689	1059	37	3	521	3	PDE1C	7	31864484	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3545520	31864484	127274179	228	25503											
BMPER	168667	broad.mit.edu	37	chr7	34009964	34009964	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcgttgtcacagagtctggGgtgcgctgtgttgttcattg	4	14	16	7	2	3	1	2	0	1	1	3	1	3	1	0	3	1	4	0	3	0	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:34009964G>A	uc011kap.1	+	5	540	c.426G>A	c.(424-426)GGG>GGA	p.G142G		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	142	VWFC 2.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						CAGAGTCTGGGGTGCGCTGTG	0.488													44	77					0	0	0	0	A	34009964	A	A	34009964	2	1	141	1	0	0	0	0	0	0	0	1	1471	1219	43	4		4	BMPER	7	34009964	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2145480	34009964	125128699	229	25504											
URGCP	55665	broad.mit.edu	37	chr7	43917780	43917780	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggcccggatcctcttcaCgaagctgtcgctgtcagtgc	6	10	12	13	3	3	0	2	0	1	0	5	3	4	1	2	2	2	2	2	2	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:43917780C>A	uc003tiw.2	-	6	1339	c.1282G>T	c.(1282-1284)GTG>TTG	p.V428L	URGCP_uc003tiu.2_Missense_Mutation_p.V385L|URGCP_uc003tiv.2_Missense_Mutation_p.V353L|URGCP_uc003tix.2_Missense_Mutation_p.V419L|URGCP_uc003tiy.2_Missense_Mutation_p.V385L|URGCP_uc003tiz.2_Missense_Mutation_p.V385L|URGCP_uc011kbj.1_Missense_Mutation_p.V385L	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	428					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						ATCCTCTTCACGAAGCTGTCG	0.537													46	110					1.48734e-19	2.09657e-19	1	0	A	43917780	A	A	43917780	3	1	141	1	0	0	0	0	1	0	0	0	17094	536	19	3	1517	3	URGCP	7	43917780	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	9907816	43917780	115220883	230	25505											
DDX56	54606	broad.mit.edu	37	chr7	44609415	44609415	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaggctcttacctccactGagaagctcctcaatcttgcc	8	10	7	16	0	3	1	1	1	2	1	5	2	5	1	5	1	3	2	5	1	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:44609415G>A	uc003tlg.2	-	9	1855	c.1212C>T	c.(1210-1212)CTC>CTT	p.L404L	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Silent_p.L340L|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Silent_p.L364L|DDX56_uc010kyh.1_RNA	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	404	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1						TACCTCCACTGAGAAGCTCCT	0.507													12	12					0	0	0	0	A	44609415	A	A	44609415	2	1	141	1	0	0	0	0	0	0	0	1	4391	1277	45	2		2	DDX56	7	44609415	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	691635	44609415	114529248	231	25506											
ZNF479	90827	broad.mit.edu	37	chr7	57194381	57194381	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatccaggcattgccattcCtccagagagaattctatagc	12	10	7	12	0	1	2	0	0	1	2	4	3	4	2	4	1	2	1	4	1	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:57194381C>T	uc010kzo.2	-	3	355	c.84G>A	c.(82-84)GAG>GAA	p.E28E		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			ATTGCCATTCCTCCAGAGAGA	0.438													30	46					0	0	0	0	T	57194381	T	T	57194381	2	4	141	1	0	0	0	0	0	0	0	1	18000	680	24	4		4	ZNF479	7	57194381	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	12584966	57194381	101944282	232	25507											
ZNF735	730291	broad.mit.edu	37	chr7	63680233	63680233	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attcacactggagagaaaccCtacgcatgtgaagaatgtgg	14	8	11	8	1	1	3	1	1	0	2	1	5	1	4	1	2	2	1	1	2	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:63680233C>A	uc011kdn.1	+	4	804	c.804C>A	c.(802-804)CCC>CCA	p.P268P		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	268					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAGAAACCCTACGCATGTG	0.448													8	22					0.000157383	0.000167921	1	0	A	63680233	A	A	63680233	2	1	141	1	0	0	0	0	0	0	0	1	18191	668	24	4		4	ZNF735	7	63680233	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	6485852	63680233	95458430	233	25508											
NSUN5	55695	broad.mit.edu	37	chr7	72718297	72718297	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggatccgagggggagacCgccaggaagtcctcctcagc	8	5	15	13	3	1	1	1	0	0	1	4	5	4	3	5	4	1	0	5	4	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:72718297C>A	uc003txw.2	-	7	900	c.864G>T	c.(862-864)GCG>GCT	p.A288A	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Silent_p.A288A|NSUN5_uc003txx.2_Silent_p.A250A|NSUN5_uc011kev.1_Silent_p.A288A	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	288							methyltransferase activity				0		Lung NSC(55;0.163)				AGGGGGAGACCGCCAGGAAGT	0.592													17	33					5.3912e-06	5.94249e-06	1	0	A	72718297	A	A	72718297	2	1	141	1	0	0	0	0	0	0	0	1	10735	639	23	3		3	NSUN5	7	72718297	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	9038064	72718297	86420366	234	25509											
PCLO	27445	broad.mit.edu	37	chr7	82584629	82584629	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcaatttataaactttttgTacttctattattttttccgg	9	21	5	6	1	1	0	0	0	1	0	2	0	2	0	1	2	2	2	1	2	7	12			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:82584629T>A	uc003uhx.2	-	5	5929	c.5640A>T	c.(5638-5640)GTA>GTT	p.V1880V	PCLO_uc003uhv.2_Silent_p.V1880V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1811					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AAACTTTTTGTACTTCTATTA	0.368													22	34					0	0	0	0	A	82584629	A	A	82584629	2	1	141	1	0	0	0	0	0	0	0	1	11637	1625	57	5		5	PCLO	7	82584629	Silent	SNP	T	TCGA-CR-7370-01A-11D-2129-08	9866332	82584629	76554034	235	25510											
ABCB1	5243	broad.mit.edu	37	chr7	87173503	87173503	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcaggcctccatttataatgGcacaaaatacaccaacaaca	17	7	5	12	0	0	0	0	0	0	0	1	0	1	0	3	2	3	2	3	2	7	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:87173503G>T	uc003uiz.1	-	18	2571	c.2153C>A	c.(2152-2154)GCC>GAC	p.A718D	ABCB1_uc011khc.1_Missense_Mutation_p.A654D	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	718	ABC transmembrane type-1 2.|Helical; (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATTTATAATGGCACAAAATAC	0.358													33	55					1.39649e-27	2.09759e-27	1	0	T	87173503	T	T	87173503	3	4	141	1	0	0	0	0	1	0	0	0	40	1203	42	4	1737	4	ABCB1	7	87173503	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4588874	87173503	71965160	236	25511											
STEAP4	79689	broad.mit.edu	37	chr7	87910388	87910388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaatggattctccttcttgaGtattgcctaagaaaaattat	14	15	6	6	0	2	2	0	1	2	1	3	3	2	3	2	1	1	1	2	1	6	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:87910388G>A	uc003ujs.2	-	4	1096	c.991C>T	c.(991-993)CTC>TTC	p.L331F	STEAP4_uc010lek.2_Missense_Mutation_p.L155F	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	331	Ferric oxidoreductase.				fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					TCCTTCTTGAGTATTGCCTAA	0.368													13	23					0	0	0	0	A	87910388	A	A	87910388	3	1	141	1	0	0	0	0	1	0	0	0	15346	1029	36	4	396	4	STEAP4	7	87910388	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	736885	87910388	71228275	237	25512											
STEAP2	261729	broad.mit.edu	37	chr7	89856546	89856546	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgacttttacaaaattcctAtagagattgtgaataaaacc	16	13	6	6	0	0	3	0	2	0	1	1	4	1	3	2	0	2	0	2	0	8	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:89856546A>G	uc003ujz.2	+	3	1147	c.754A>G	c.(754-756)ATA>GTA	p.I252V	STEAP2_uc003ujy.2_Missense_Mutation_p.I294V|STEAP2_uc010len.2_Missense_Mutation_p.I252V|STEAP2_uc003uka.2_Missense_Mutation_p.I252V|STEAP2_uc003ukb.2_Missense_Mutation_p.I252V|STEAP2_uc003ukc.2_Missense_Mutation_p.I252V|STEAP2_uc003ukd.2_Missense_Mutation_p.I252V	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	252					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					CAAAATTCCTATAGAGATTGT	0.378													36	62					0	0	0	0	G	89856546	G	G	89856546	3	3	141	1	0	0	0	0	1	0	0	0	15344	449	16	5	760	5	STEAP2	7	89856546	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	1946158	89856546	69282117	238	25513											
PEX1	5189	broad.mit.edu	37	chr7	92143172	92143172	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaactcactaaattctctCtaggttgtaactttagagat	12	16	6	7	0	3	2	1	1	2	1	4	3	3	2	0	1	2	2	0	1	6	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:92143172C>G	uc003uly.2	-	6	1445	c.1349G>C	c.(1348-1350)AGA>ACA	p.R450T	PEX1_uc011khr.1_Missense_Mutation_p.R242T|PEX1_uc010ley.2_Missense_Mutation_p.R450T|PEX1_uc011khs.1_Missense_Mutation_p.R128T|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	450					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TAAATTCTCTCTAGGTTGTAA	0.328													41	70					0	0	0	0	G	92143172	G	G	92143172	3	3	141	1	0	0	0	0	1	0	0	0	11790	913	32	2	2578	2	PEX1	7	92143172	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2286626	92143172	66995491	239	25514											
HEPACAM2	253012	broad.mit.edu	37	chr7	92848626	92848626	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtatttgggcattgtgtggGgtctctcaaatagccatatg	9	14	12	6	0	2	0	1	0	1	0	3	0	2	0	1	3	1	2	1	3	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:92848626G>A	uc003umm.2	-	2	241	c.218C>T	c.(217-219)CCC>CTC	p.P73L	HEPACAM2_uc003uml.2_Missense_Mutation_p.P61L|HEPACAM2_uc010lff.2_Missense_Mutation_p.P61L|HEPACAM2_uc011khy.1_Missense_Mutation_p.P96L	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	73	Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						CATTGTGTGGGGTCTCTCAAA	0.498													38	55					0	0	0	0	A	92848626	A	A	92848626	3	1	141	1	0	0	0	0	1	0	0	0	7092	1232	43	4	1206	4	HEPACAM2	7	92848626	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	705454	92848626	66290037	240	25515											
FBXO24	26261	broad.mit.edu	37	chr7	100192139	100192139	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtggcctgcatgacttccaaCcagagcagcaccctctacgt	9	8	9	15	1	1	2	0	1	1	1	2	2	2	2	4	1	5	3	4	1	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:100192139C>A	uc003uvm.1	+	6	1220	c.927C>A	c.(925-927)AAC>AAA	p.N309K	FBXO24_uc003uvl.1_Missense_Mutation_p.N295K|FBXO24_uc003uvn.1_Missense_Mutation_p.N4K|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Missense_Mutation_p.N347K|FBXO24_uc011kka.1_Missense_Mutation_p.N297K	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	309						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TGACTTCCAACCAGAGCAGCA	0.602													18	22					5.01169e-05	5.37858e-05	1	0	A	100192139	A	A	100192139	3	1	141	1	0	0	0	0	1	0	0	0	5767	506	18	4	1106	4	FBXO24	7	100192139	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	7343513	100192139	58946524	241	25516											
ACHE	43	broad.mit.edu	37	chr7	100490790	100490790	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctagccactagttacctgcAggccgtggaagtctcccgcg	7	8	12	14	3	1	0	0	0	1	0	2	1	1	1	4	2	3	3	4	2	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:100490790A>G	uc003uxd.2	-	1	1220	c.1064T>C	c.(1063-1065)CTG>CCG	p.L355P	ACHE_uc003uxe.2_Missense_Mutation_p.L355P|ACHE_uc003uxf.2_Missense_Mutation_p.L355P|ACHE_uc003uxg.2_Missense_Mutation_p.L355P|ACHE_uc003uxh.2_Missense_Mutation_p.L355P|ACHE_uc003uxi.2_Missense_Mutation_p.L355P|ACHE_uc003uxj.1_Missense_Mutation_p.L474P	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	355					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	AGTTACCTGCAGGCCGTGGAA	0.622													7	19					0	0	0	0	G	100490790	G	G	100490790	3	3	141	1	0	0	0	0	1	0	0	0	141	188	7	5	931	5	ACHE	7	100490790	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	298651	100490790	58647873	242	25517											
RELN	5649	broad.mit.edu	37	chr7	103389906	103389906	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttaattgcagttggtggtagGagtcaaagtcatctctcagg	10	13	12	6	0	4	0	3	0	1	0	5	1	4	1	0	4	1	3	0	4	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:103389906G>T	uc003vca.2	-	6	783	c.623C>A	c.(622-624)TCC>TAC	p.S208Y	RELN_uc010liz.2_Missense_Mutation_p.S208Y	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	208					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTGGTGGTAGGAGTCAAAGTC	0.343													57	70					2.165e-29	3.26532e-29	1	0	T	103389906	T	T	103389906	3	4	141	1	0	0	0	0	1	0	0	0	13285	1174	41	2	9999	2	RELN	7	103389906	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2899116	103389906	55748757	243	25518											
LAMB4	22798	broad.mit.edu	37	chr7	107704266	107704266	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttgcagagctggcagtttgCgccctgagtgttgtgcaaac	7	12	13	9	1	0	2	0	1	0	1	0	2	0	2	1	1	5	6	1	1	1	3	rs142967094		TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:107704266C>T	uc010ljo.1	-	22	3085	c.3001G>A	c.(3001-3003)GCA>ACA	p.A1001T	LAMB4_uc003vey.2_Missense_Mutation_p.A1001T|LAMB4_uc010ljp.1_5'UTR	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1001	Laminin EGF-like 10.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TGGCAGTTTGCGCCCTGAGTG	0.527													51	107					0	0	0	0	T	107704266	T	T	107704266	3	4	141	1	0	0	0	0	1	0	0	0	8653	768	27	1	2336	1	LAMB4	7	107704266	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4314360	107704266	51434397	244	25519											
IFRD1	3475	broad.mit.edu	37	chr7	112097034	112097034	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttcaaaaatgctgtatgAatttattctggaaaggagaa	15	12	10	4	0	2	2	1	1	1	1	2	4	2	3	0	3	1	3	0	3	7	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:112097034A>G	uc003vgh.2	+	5	793	c.350A>G	c.(349-351)GAA>GGA	p.E117G	IFRD1_uc011kmn.1_Missense_Mutation_p.E67G|IFRD1_uc003vgi.2_Missense_Mutation_p.E117G|IFRD1_uc003vgj.2_Missense_Mutation_p.E117G|IFRD1_uc011kmo.1_RNA|IFRD1_uc011kmp.1_Missense_Mutation_p.E67G	NM_001007245	NP_001007246	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	117					multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2						ATGCTGTATGAATTTATTCTG	0.368													26	40					0	0	0	0	G	112097034	G	G	112097034	3	3	141	1	0	0	0	0	1	0	0	0	7592	246	9	5	364	5	IFRD1	7	112097034	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	4392768	112097034	47041629	245	25520											
PPP1R3A	5506	broad.mit.edu	37	chr7	113518193	113518193	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctttcttttctactacctGatgtcactattcctgaactt	8	19	3	11	0	4	2	1	2	3	0	5	2	5	2	2	0	3	0	2	0	4	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:113518193G>T	uc010ljy.1	-	4	2985	c.2954C>A	c.(2953-2955)TCA>TAA	p.S985*		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	985					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TCTACTACCTGATGTCACTAT	0.368													12	90					1.08611e-07	1.24006e-07	1	0	T	113518193	T	T	113518193	4	4	141	1	0	0	0	0	0	1	0	0	12431	1294	45	2	418	2	PPP1R3A	7	113518193	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1421159	113518193	45620470	246	25521											
RNF133	168433	broad.mit.edu	37	chr7	122338457	122338457	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctcaaccacggctgtaatGagaactcccttcttaattaa	13	11	5	12	1	2	1	1	1	1	1	3	2	3	1	3	1	2	2	3	1	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:122338457G>A	uc003vkj.1	-	1	752	c.516C>T	c.(514-516)CTC>CTT	p.L172L	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	172						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						CGGCTGTAATGAGAACTCCCT	0.398													51	96					0	0	0	0	A	122338457	A	A	122338457	2	1	141	1	0	0	0	0	0	0	0	1	13504	1277	45	2		2	RNF133	7	122338457	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	8820264	122338457	36800206	247	25522											
RNF133	168433	broad.mit.edu	37	chr7	122338764	122338764	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactataactcctgccactCtcttcaaagtggagcttctt	9	13	6	13	0	3	0	1	0	2	0	5	1	4	1	2	1	3	2	2	1	3	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:122338764C>A	uc003vkj.1	-	1	445	c.209G>T	c.(208-210)AGA>ATA	p.R70I	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	70	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						TCCTGCCACTCTCTTCAAAGT	0.433													63	78					2.44918e-20	3.46574e-20	1	0	A	122338764	A	A	122338764	3	1	141	1	0	0	0	0	1	0	0	0	13504	913	32	2	925	2	RNF133	7	122338764	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	307	122338764	36799899	248	25523											
NDUFA5	4698	broad.mit.edu	37	chr7	123197486	123197486	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagtattgcacacagccaatCccacaaggccagtggtctgt	11	8	10	12	0	1	0	0	0	1	0	2	1	2	0	3	2	2	2	3	2	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:123197486C>G	uc003vks.2	-	2	147	c.38G>C	c.(37-39)GGA>GCA	p.G13A	NDUFA5_uc003vkr.2_RNA|NDUFA5_uc003vkt.1_Missense_Mutation_p.G13A	NM_005000	NP_004991	Q16718	NDUA5_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	13					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	CACAGCCAATCCCACAAGGCC	0.423													5	54					0	0	0	0	G	123197486	G	G	123197486	3	3	141	1	0	0	0	0	1	0	0	0	10322	855	30	2	328	2	NDUFA5	7	123197486	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	858722	123197486	35941177	249	25524											
GCC1	79571	broad.mit.edu	37	chr7	127224972	127224972	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgctatcctcgctgtgagTggagcaccggtcatccacag	8	9	12	12	2	1	1	1	1	0	0	4	2	3	2	3	2	2	3	3	2	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:127224972T>A	uc003vma.2	-	1	683	c.265A>T	c.(265-267)ACT>TCT	p.T89S		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	89						Golgi membrane|plasma membrane	protein binding			ovary(2)	2						TCGCTGTGAGTGGAGCACCGG	0.597													26	44					0	0	0	0	A	127224972	A	A	127224972	3	1	141	1	0	0	0	0	1	0	0	0	6320	1696	59	5	2070	5	GCC1	7	127224972	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	4027486	127224972	31913691	250	25525											
RAB19	401409	broad.mit.edu	37	chr7	140125809	140125809	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaagaacatagaagaagtCttcgtgctcatggccaagga	15	8	10	8	1	3	3	2	0	1	3	4	4	3	4	1	2	2	1	1	2	6	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:140125809C>T	uc010lni.2	+	4	711	c.513C>T	c.(511-513)GTC>GTT	p.V171V	RAB19_uc011krc.1_Silent_p.V171V	NM_001008749	NP_001008749	A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	171					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0	Melanoma(164;0.0142)					TAGAAGAAGTCTTCGTGCTCA	0.582													31	92					0	0	0	0	T	140125809	T	T	140125809	2	4	141	1	0	0	0	0	0	0	0	1	12969	900	32	2		2	RAB19	7	140125809	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	12900837	140125809	19012854	251	25526											
TAS2R4	50832	broad.mit.edu	37	chr7	141478516	141478516	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtctcttcaaatacggaaagGtcagtctacctgtctgcttt	9	14	8	10	1	5	0	2	0	3	0	6	1	5	1	1	2	3	1	1	2	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:141478516G>A	uc003vwq.1	+	1	228	c.228G>A	c.(226-228)AGG>AGA	p.R76R		NM_016944	NP_058640	Q9NYW5	TA2R4_HUMAN	taste receptor T2R4	76	Extracellular (Potential).				sensory perception of taste	cilium membrane	taste receptor activity				0	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		ATACGGAAAGGTCAGTCTACC	0.433													65	116					0	0	0	0	A	141478516	A	A	141478516	2	1	141	1	0	0	0	0	0	0	0	1	15643	1252	44	4		4	TAS2R4	7	141478516	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1352707	141478516	17660147	252	25527											
PRSS1	5644	broad.mit.edu	37	chr7	142459743	142459743	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaggaagactctgaacaatGacatcatgttaatcaagctc	16	9	7	9	0	3	3	2	2	1	1	4	4	3	4	0	1	2	2	0	1	5	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:142459743G>A	uc003wak.2	+	3	336	c.319G>A	c.(319-321)GAC>AAC	p.D107N	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.D47N	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	107	Peptidase S1.	Charge relay system.			digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			TCTGAACAATGACATCATGTT	0.552									Hereditary_Pancreatitis				11	165					0	0	0	0	A	142459743	A	A	142459743	3	1	141	1	0	0	0	0	1	0	0	0	12676	1290	45	2	329	2	PRSS1	7	142459743	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	981227	142459743	16678920	253	25528											
OR2F1	26211	broad.mit.edu	37	chr7	143657597	143657597	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtttattgatcacatatcCtgtgaactcctagctgtggt	10	15	8	8	0	1	2	1	2	0	0	3	2	3	2	2	1	2	2	2	1	5	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:143657597C>T	uc003wds.1	+	1	578	c.534C>T	c.(532-534)TCC>TCT	p.S178S		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					ATCACATATCCTGTGAACTCC	0.498													36	56					0	0	0	0	T	143657597	T	T	143657597	2	4	141	1	0	0	0	0	0	0	0	1	11050	668	24	4		4	OR2F1	7	143657597	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1197854	143657597	15481066	254	25529											
ZNF425	155054	broad.mit.edu	37	chr7	148800930	148800930	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggaccttcaagctgcccCtgatgcagtagctcttgtca	8	11	10	12	0	3	1	2	1	1	0	3	2	3	2	3	1	4	4	3	1	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:148800930C>T	uc003wfj.2	-	4	2106	c.2033G>A	c.(2032-2034)AGG>AAG	p.R678K		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	678	C2H2-type 17.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CAAGCTGCCCCTGATGCAGTA	0.547													56	95					0	0	0	0	T	148800930	T	T	148800930	3	4	141	1	0	0	0	0	1	0	0	0	17966	681	24	4	229	4	ZNF425	7	148800930	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	5143333	148800930	10337733	255	25530											
GIMAP8	155038	broad.mit.edu	37	chr7	150164299	150164299	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactgcattttcaacaacaaGaccaatagtaaggatgagca	17	9	7	8	0	1	2	1	1	0	1	1	3	1	3	1	1	5	3	1	1	7	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:150164299G>A	uc003whj.2	+	2	843	c.513G>A	c.(511-513)AAG>AAA	p.K171K		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	171						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TCAACAACAAGACCAATAGTA	0.443													8	142					0	0	0	0	A	150164299	A	A	150164299	2	1	141	1	0	0	0	0	0	0	0	1	6422	933	33	2		2	GIMAP8	7	150164299	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1363369	150164299	8974364	256	25531											
AGAP3	116988	broad.mit.edu	37	chr7	150784095	150784095	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctacgccatctacgacctGatcgagcgcatcgaggattt	10	10	9	12	5	2	1	0	1	2	0	4	5	2	2	2	1	3	1	2	1	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:150784095G>T	uc003wjg.1	+	1	270	c.267G>T	c.(265-267)CTG>CTT	p.L89L	AGAP3_uc003wje.1_Intron|AGAP3_uc003wjf.1_Silent_p.L89L|AGAP3_uc010lpy.1_Silent_p.L89L	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	53					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						TCTACGACCTGATCGAGCGCA	0.667													7	12					1.76689e-08	2.0689e-08	1	0	T	150784095	T	T	150784095	2	4	141	1	0	0	0	0	0	0	0	1	369	1277	45	2		2	AGAP3	7	150784095	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	619796	150784095	8354568	257	25532											
MLL3	58508	broad.mit.edu	37	chr7	151877135	151877135	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggcactgcgggtgagtccTgtgaccccttctcctgtcga	5	10	13	13	2	1	2	0	2	1	0	4	4	2	2	4	2	1	1	4	2	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:151877135T>C	uc003wla.2	-	37	7445	c.7226A>G	c.(7225-7227)CAG>CGG	p.Q2409R	MLL3_uc003wkz.2_Missense_Mutation_p.Q1470R|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2409					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGGTGAGTCCTGTGACCCCTT	0.517			N		medulloblastoma								99	190					0	0	0	0	C	151877135	C	C	151877135	3	2	141	1	0	0	0	0	1	0	0	0	9675	1580	55	5	7601	5	MLL3	7	151877135	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	1093040	151877135	7261528	258	25533											
DLGAP2	9228	broad.mit.edu	37	chr8	1497720	1497720	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgacgccaagtacctgaaGcgcagctcctggtctacgct	8	7	10	16	4	1	1	0	1	1	0	2	2	2	1	4	1	4	4	4	1	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:1497720G>A	uc003wpl.2	+	2	958	c.861G>A	c.(859-861)AAG>AAA	p.K287K	DLGAP2_uc003wpm.2_Silent_p.K287K	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	366					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		AGTACCTGAAGCGCAGCTCCT	0.642													11	40					0	0	0	0	A	1497720	A	A	1497720	2	1	141	1	0	0	0	0	0	0	0	1	4582	962	34	4		4	DLGAP2	8	1497720	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08		1497720	144866302	259	25534											
CSMD1	64478	broad.mit.edu	37	chr8	3226842	3226842	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggataaaaatctggaaaccCaggagaaaggactgttccac	16	7	10	8	0	1	1	0	0	1	1	2	5	2	4	2	4	1	1	2	4	5	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:3226842C>A	uc011kwk.1	-	19	3226	c.2836G>T	c.(2836-2838)GGG>TGG	p.G946W	CSMD1_uc011kwj.1_Missense_Mutation_p.G338W|CSMD1_uc003wqe.2_Missense_Mutation_p.G102W	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	946	Extracellular (Potential).|CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCTGGAAACCCAGGAGAAAGG	0.393													17	14					6.94344e-10	8.38475e-10	1	0	A	3226842	A	A	3226842	3	1	141	1	0	0	0	0	1	0	0	0	3961	594	21	4	8069	4	CSMD1	8	3226842	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1729122	3226842	143137180	260	25535											
XKR6	286046	broad.mit.edu	37	chr8	10782284	10782284	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcatagcccagtagaagcgtCgctggtgttccttccgccgc	6	10	11	14	4	1	1	1	0	0	1	4	1	3	1	4	1	2	3	4	1	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:10782284C>T	uc003wtk.1	-	2	848	c.821G>A	c.(820-822)CGA>CAA	p.R274Q		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	274						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		GTAGAAGCGTCGCTGGTGTTC	0.582													7	117					0	0	0	0	T	10782284	T	T	10782284	3	4	141	1	0	0	0	0	1	0	0	0	17503	884	31	1	1112	1	XKR6	8	10782284	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	7555442	10782284	135581738	261	25536											
SGCZ	137868	broad.mit.edu	37	chr8	13959908	13959909	+	Missense_Mutation	DNP	GG	TT	TT																															cccttctgtagattgcagatGgagctccttcctgcaggtgg																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:13959908_13959909GG>TT	uc003wwq.2	-	7	1380_1381	c.720_721CC>AA	c.(718-723)CTCCAT>CTAAAT	p.H241N	SGCZ_uc010lss.2_Missense_Mutation_p.H194N	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	228	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GATTGCAGATGGAGCTCCTTCC	0.515													24	63					0	0	0	0	TT	13959909	TT	TT	13959908	3	4	141	1	0	0	0	0	1	0	0	0	14269	1348	47	4	225	4	SGCZ	8	13959908	Missense_Mutation	DNP	GG	TCGA-CR-7370-01A-11D-2129-08	3177624	13959908	132404114	262	25537											
ENTPD4	9583	broad.mit.edu	37	chr8	23243466	23243466	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaagcagcacattgcaagTgtttggtggccccatatggt	9	11	11	10	0	0	0	0	0	0	0	1	0	1	0	3	3	3	4	3	3	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:23243466T>G	uc011kzu.1	-	13	1963	c.1691A>C	c.(1690-1692)CAC>CCC	p.H564P	LOXL2_uc003xdh.1_Intron	NM_001128930	NP_001122402	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	Error:Variant_position_missing_in_Q9Y227_after_alignment					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		acattgcaagtgtttggtggc	0.015													35	92					0	0	0	0	G	23243466	G	G	23243466	3	3	141	1	0	0	0	0	1	0	0	0	5165	1711	59	5		5	ENTPD4	8	23243466	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	9283558	23243466	123120556	263	25538											
ADRA1A	148	broad.mit.edu	37	chr8	26721992	26721992	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcctcgggggccggctgcctCcagccgaacaggggtccaat	6	6	14	15	3	0	0	0	0	0	0	4	1	3	0	6	5	3	1	6	5	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:26721992C>G	uc003xfh.1	-	1	931	c.495G>C	c.(493-495)TGG>TGC	p.W165C	ADRA1A_uc003xfc.1_Missense_Mutation_p.W165C|ADRA1A_uc010lul.1_Missense_Mutation_p.W165C|ADRA1A_uc003xfd.1_RNA|ADRA1A_uc003xfe.1_Missense_Mutation_p.W165C|ADRA1A_uc010lum.1_Missense_Mutation_p.W165C|ADRA1A_uc003xff.1_RNA|ADRA1A_uc003xfg.1_Missense_Mutation_p.W165C	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	165	Helical; Name=4; (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	CCGGCTGCCTCCAGCCGAACA	0.637													30	32					0	0	0	0	G	26721992	G	G	26721992	3	3	141	1	0	0	0	0	1	0	0	0	334	856	30	2	1204	2	ADRA1A	8	26721992	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3478526	26721992	119642030	264	25539											
KIF13B	23303	broad.mit.edu	37	chr8	29037627	29037627	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgaacacctaccccagaCttcacatcgtagagagtatg	13	9	7	12	1	2	3	1	1	1	2	3	4	2	3	3	0	2	2	3	0	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:29037627C>T	uc003xhh.3	-	8	773	c.714G>A	c.(712-714)AAG>AAA	p.K238K	KIF13B_uc003xhj.2_Silent_p.K135K|KIF13B_uc010lvf.1_Silent_p.K174K	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	238	Kinesin-motor.				microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CTACCCCAGACTTCACATCGT	0.408													52	135					0	0	0	0	T	29037627	T	T	29037627	2	4	141	1	0	0	0	0	0	0	0	1	8314	564	20	4		4	KIF13B	8	29037627	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2315635	29037627	117326395	265	25540											
ST18	9705	broad.mit.edu	37	chr8	53025853	53025853	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagattgctgtacatatctgTgagtgtatttacatatgctt	10	17	8	6	0	1	2	0	1	1	1	1	2	1	2	0	0	4	4	0	0	5	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:53025853T>G	uc003xqz.2	-	21	3205	c.3049A>C	c.(3049-3051)ACA>CCA	p.T1017P	ST18_uc011ldq.1_Missense_Mutation_p.T664P|ST18_uc011ldr.1_Missense_Mutation_p.T982P|ST18_uc011lds.1_Missense_Mutation_p.T922P|ST18_uc003xra.2_Missense_Mutation_p.T1017P	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	1017						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TACATATCTGTGAGTGTATTT	0.433													31	88					0	0	0	0	G	53025853	G	G	53025853	3	3	141	1	0	0	0	0	1	0	0	0	15278	1696	59	5	98	5	ST18	8	53025853	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	23988226	53025853	93338169	266	25541											
RP1	6101	broad.mit.edu	37	chr8	55540739	55540739	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaagtttcaggatgaaaatGcatatacttcctttgatatg	13	14	9	5	0	1	2	1	2	0	0	2	4	2	4	1	2	2	2	1	2	6	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:55540739G>T	uc003xsd.1	+	4	4445	c.4297G>T	c.(4297-4299)GCA>TCA	p.A1433S	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1433					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGATGAAAATGCATATACTTC	0.363													26	72					1.42536e-11	1.78902e-11	1	0	T	55540739	T	T	55540739	3	4	141	1	0	0	0	0	1	0	0	0	13597	1319	46	4	4307	4	RP1	8	55540739	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2514886	55540739	90823283	267	25542											
LYN	4067	broad.mit.edu	37	chr8	56879420	56879420	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acgctgtggtcaccagggagGagcccatttacatcatcacc	10	8	10	13	1	3	0	3	0	0	0	3	2	3	2	3	3	2	1	3	3	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:56879420G>T	uc003xsk.3	+	9	1219	c.937G>T	c.(937-939)GAG>TAG	p.E313*	LYN_uc003xsl.3_Nonsense_Mutation_p.E292*	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	313	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			CACCAGGGAGGAGCCCATTTA	0.512													15	57					1.5739e-10	1.93244e-10	1	0	T	56879420	T	T	56879420	4	4	141	1	0	0	0	0	0	1	0	0	9158	1175	41	2	967	2	LYN	8	56879420	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1338681	56879420	89484602	268	25543											
NSMAF	8439	broad.mit.edu	37	chr8	59514633	59514633	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ataccagtagtctctccagcCgttccttatttagggcccct	7	13	7	14	1	1	0	0	0	1	0	4	0	3	0	6	1	2	2	6	1	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:59514633C>A	uc003xtt.2	-	14	1323	c.1109G>T	c.(1108-1110)CGG>CTG	p.R370L	NSMAF_uc011lee.1_Missense_Mutation_p.R401L|NSMAF_uc003xtu.2_Missense_Mutation_p.R370L	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	370	BEACH.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				TCTCTCCAGCCGTTCCTTATT	0.413													39	112					1.7489e-18	2.40515e-18	1	0	A	59514633	A	A	59514633	3	1	141	1	0	0	0	0	1	0	0	0	10728	652	23	3	1716	3	NSMAF	8	59514633	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2635213	59514633	86849389	269	25544											
NSMAF	8439	broad.mit.edu	37	chr8	59548030	59548030	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttaaaatgtatttaccttGatgatgggctgggatattga	12	16	10	3	0	0	3	0	3	0	0	0	4	0	4	1	2	1	2	1	2	5	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:59548030G>C	uc003xtt.2	-	3	439	c.225C>G	c.(223-225)ATC>ATG	p.I75M	NSMAF_uc011lee.1_Missense_Mutation_p.I106M|NSMAF_uc003xtu.2_Missense_Mutation_p.I75M	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	75					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				TATTTACCTTGATGATGGGCT	0.308													12	227					0	0	0	0	C	59548030	C	C	59548030	3	2	141	1	0	0	0	0	1	0	0	0	10728	1280	45	2	2644	2	NSMAF	8	59548030	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	33397	59548030	86815992	270	25545											
ASPH	444	broad.mit.edu	37	chr8	62415961	62415961	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgctgtggtgtcagttccGgatgccacacatccacgatg	7	11	11	12	2	2	0	1	0	1	0	4	2	4	1	3	2	2	2	3	2	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:62415961G>A	uc003xuj.2	-	25	2503	c.2234C>T	c.(2233-2235)CCG>CTG	p.P745L	ASPH_uc011leg.1_Missense_Mutation_p.P716L	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	745	Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	TGTCAGTTCCGGATGCCACAC	0.512													4	51					0	0	0	0	A	62415961	A	A	62415961	3	1	141	1	0	0	0	0	1	0	0	0	1055	1116	39	1	46	1	ASPH	8	62415961	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2867931	62415961	83948061	271	25546											
BHLHE22	27319	broad.mit.edu	37	chr8	65493499	65493499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccctggcgccgccgcctcGggaacgcccggcgtcctcct	2	6	13	20	7	0	0	0	0	0	0	4	1	3	1	7	3	1	0	7	3	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:65493499G>A	uc003xvi.2	+	1	686	c.152G>A	c.(151-153)CGG>CAG	p.R51Q	LOC401463_uc003xvh.2_Intron	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	51					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						CCGCCGCCTCGGGAACGCCCG	0.706													8	5					0	0	0	0	A	65493499	A	A	65493499	3	1	141	1	0	0	0	0	1	0	0	0	1424	1116	39	1	154	1	BHLHE22	8	65493499	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3077538	65493499	80870523	272	25547											
ZFHX4	79776	broad.mit.edu	37	chr8	77767550	77767550	+	Frame_Shift_Del	DEL	C	-	-																															tgggtatgatcaaaataaaaCcgattttgatgagacttcat																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:77767550delC	uc003yav.2	+	10	8645	c.8258delC	c.(8257-8259)ACCfs	p.T2753fs	ZFHX4_uc003yau.1_Frame_Shift_Del_p.T2798fs|ZFHX4_uc003yaw.1_Frame_Shift_Del_p.T2753fs	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2753						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAAAATAAAACCGATTTTGAT	0.438										HNSCC(33;0.089)			---	---	---								-	77767550	-	-	77767550	7	5	141	1	0	1	0	1	0	0	0	0	17702	507	18	0	8427	0	ZFHX4	8	77767550	Frame_Shift_Del	DEL	C	TCGA-CR-7370-01A-11D-2129-08	12274051	77767550	68596472	273	25548											
ATP6V0D2	245972	broad.mit.edu	37	chr8	87126074	87126074	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagtatttccggaatcattcCctggagcccctcagcacatt	9	11	8	13	1	2	0	2	0	0	0	4	3	4	2	4	2	2	2	4	2	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:87126074C>A	uc003ydp.1	+	2	336	c.267C>A	c.(265-267)TCC>TCA	p.S89S		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	89					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0						GGAATCATTCCCTGGAGCCCC	0.423													25	121					4.59853e-10	5.57144e-10	1	0	A	87126074	A	A	87126074	2	1	141	1	0	0	0	0	0	0	0	1	1176	610	22	4		4	ATP6V0D2	8	87126074	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	9358524	87126074	59237948	274	25549											
MMP16	4325	broad.mit.edu	37	chr8	89128829	89128829	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgggataggagggtctgccGgttggaggccgaggaggttt	6	8	20	7	3	1	0	0	0	1	0	1	5	1	4	3	8	1	2	3	8	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:89128829G>A	uc003yeb.3	-	6	1272	c.990C>T	c.(988-990)ACC>ACT	p.T330T	MMP16_uc003yec.2_Silent_p.T330T	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	330	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						AGGGTCTGCCGGTTGGAGGCC	0.532													78	56					0	0	0	0	A	89128829	A	A	89128829	2	1	141	1	0	0	0	0	0	0	0	1	9708	1103	39	1		1	MMP16	8	89128829	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2002755	89128829	57235193	275	25550											
RIPK2	8767	broad.mit.edu	37	chr8	90777691	90777691	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcatgacttgaagactcaGaatatcttattggacaatga	15	12	7	7	0	3	5	2	3	1	2	3	6	3	6	0	1	0	0	0	1	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:90777691G>A	uc003yee.2	+	3	764	c.450G>A	c.(448-450)CAG>CAA	p.Q150Q	RIPK2_uc003yef.2_Silent_p.Q13Q	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	150	Protein kinase.				activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TGAAGACTCAGAATATCTTAT	0.313													7	90					0	0	0	0	A	90777691	A	A	90777691	2	1	141	1	0	0	0	0	0	0	0	1	13446	933	33	2		2	RIPK2	8	90777691	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1648862	90777691	55586331	276	25551											
CALB1	793	broad.mit.edu	37	chr8	91081386	91081386	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagctttcttataccttcAtgaattcctcacaggacttc	9	14	6	12	0	3	1	2	1	1	0	5	2	4	2	2	2	2	2	2	2	3	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:91081386A>T	uc003yel.1	-	4	493	c.311T>A	c.(310-312)ATG>AAG	p.M104K	CALB1_uc011lge.1_Missense_Mutation_p.M47K	NM_004929	NP_004920	P05937	CALB1_HUMAN	calbindin 1	104	EF-hand 3.					nucleus	calcium ion binding|vitamin D binding			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.00953)			TTATACCTTCATGAATTCCTC	0.378													8	57					0	0	0	0	T	91081386	T	T	91081386	3	4	141	1	0	0	0	0	1	0	0	0	2585	217	8	5	506	5	CALB1	8	91081386	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	303695	91081386	55282636	277	25552											
RUNX1T1	862	broad.mit.edu	37	chr8	93003956	93003956	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caatggccatatcatccaaaCggtaatgctgaggtggaggt	12	9	12	8	1	1	1	1	1	0	0	2	2	2	2	2	5	2	2	2	5	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:93003956C>T	uc003yfd.2	-	6	986	c.902G>A	c.(901-903)CGT>CAT	p.R301H	RUNX1T1_uc003yfc.1_Missense_Mutation_p.R274H|RUNX1T1_uc003yfe.1_Missense_Mutation_p.R264H|RUNX1T1_uc010mao.2_Missense_Mutation_p.R274H|RUNX1T1_uc011lgi.1_Missense_Mutation_p.R312H|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Missense_Mutation_p.R264H	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	301					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			ATCATCCAAACGGTAATGCTG	0.552													20	124					0	0	0	0	T	93003956	T	T	93003956	3	4	141	1	0	0	0	0	1	0	0	0	13812	536	19	1	936	1	RUNX1T1	8	93003956	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1922570	93003956	53360066	278	25553											
RUNX1T1	862	broad.mit.edu	37	chr8	93027017	93027017	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgagggggcgccattcaaGgctgtaggagaatggctcgt	8	8	18	7	2	1	2	1	1	0	1	2	3	1	2	1	6	0	3	1	6	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:93027017G>A	uc003yfd.2	-	3	342	c.258C>T	c.(256-258)GCC>GCT	p.A86A	RUNX1T1_uc003yfc.1_Silent_p.A59A|RUNX1T1_uc003yfe.1_Silent_p.A49A|RUNX1T1_uc010mao.2_Silent_p.A59A|RUNX1T1_uc011lgi.1_Silent_p.A97A|RUNX1T1_uc003yfh.1_Silent_p.A49A|RUNX1T1_uc003yfb.1_Silent_p.A49A|RUNX1T1_uc003yff.1_Silent_p.A49A|RUNX1T1_uc003yfg.1_Silent_p.A49A	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	86					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CGCCATTCAAGGCTGTAGGAG	0.512													8	51					0	0	0	0	A	93027017	A	A	93027017	2	1	141	1	0	0	0	0	0	0	0	1	13812	987	35	4		4	RUNX1T1	8	93027017	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	23061	93027017	53337005	279	25554											
FAM135B	51059	broad.mit.edu	37	chr8	139149455	139149455	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgaatgaaatggcacataaCggtcttggggagaagcaacc	14	7	12	8	1	1	3	0	2	1	1	1	4	1	3	1	4	3	2	1	4	5	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:139149455C>G	uc003yuy.2	-	19	4121	c.3950G>C	c.(3949-3951)CGT>CCT	p.R1317P	FAM135B_uc003yux.2_Missense_Mutation_p.R1218P|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1317										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGGCACATAACGGTCTTGGGG	0.413										HNSCC(54;0.14)			24	117					0	0	0	0	G	139149455	G	G	139149455	3	3	141	1	0	0	0	0	1	0	0	0	5477	536	19	3	278	3	FAM135B	8	139149455	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	46122438	139149455	7214567	280	25555											
COL22A1	169044	broad.mit.edu	37	chr8	139603718	139603718	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggccaactccaggtgcacCtgggtcacctttggctcctc	6	9	11	15	0	1	0	1	0	0	0	4	1	3	0	5	4	2	2	5	4	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:139603718C>T	uc003yvd.2	-	64	5089	c.4642G>A	c.(4642-4644)GGT>AGT	p.G1548S	COL22A1_uc011ljo.1_Missense_Mutation_p.G828S	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1548	Pro-rich.|Gly-rich.|Collagen-like 15.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCAGGTGCACCTGGGTCACCT	0.602										HNSCC(7;0.00092)			3	19					0	0	0	0	T	139603718	T	T	139603718	3	4	141	1	0	0	0	0	1	0	0	0	3696	681	24	4	246	4	COL22A1	8	139603718	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	454263	139603718	6760304	281	25556											
FLJ43860	389690	broad.mit.edu	37	chr8	142486153	142486153	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaagaggcaggtgtgcttctCcagggcatccagcagtggca	10	7	14	10	0	1	1	0	0	1	1	3	1	2	1	2	4	2	5	2	4	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:142486153C>G	uc003ywi.2	-	13	1621	c.1540G>C	c.(1540-1542)GAG>CAG	p.E514Q	FLJ43860_uc011ljs.1_Intron|FLJ43860_uc010meu.1_Intron	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	514							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GTGTGCTTCTCCAGGGCATCC	0.642													6	19					0	0	0	0	G	142486153	G	G	142486153	3	3	141	1	0	0	0	0	1	0	0	0	5962	864	30	2	2488	2	FLJ43860	8	142486153	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2882435	142486153	3877869	282	25557											
RPL8	6132	broad.mit.edu	37	chr8	146017246	146017246	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcttaaaccgatacggatcCcggaagaccaccttggcgag	11	8	10	12	4	1	1	0	0	1	1	2	5	2	3	4	3	2	0	4	3	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:146017246C>A	uc003zeb.2	-	3	303	c.192G>T	c.(190-192)CGG>CGT	p.R64R	RPL8_uc003zdz.2_RNA|RPL8_uc003zea.2_Intron|RPL8_uc003zec.2_Silent_p.R64R|RPL8_uc010mgc.2_Silent_p.R64R	NM_033301	NP_150644	P62917	RL8_HUMAN	ribosomal protein L8	64					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	rRNA binding|structural constituent of ribosome				0	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.191)		GATACGGATCCCGGAAGACCA	0.657													33	171					3.28013e-08	3.80433e-08	1	0	A	146017246	A	A	146017246	2	1	141	1	0	0	0	0	0	0	0	1	13667	610	22	4		4	RPL8	8	146017246	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3531093	146017246	346776	283	25558											
CDKN2A	1029	broad.mit.edu	37	chr9	21971035	21971035	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcagacggccccaggcaTcgcgcacgtccagccgcgcc	6	2	14	19	7	0	1	0	0	0	1	2	1	1	1	5	3	1	3	5	3	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:21971035T>A	uc003zpk.2	-	2	535	c.323A>T	c.(322-324)GAT>GTT	p.D108V	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.R163R	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	108			D -> Y (in a head and neck tumor).|D -> H (in a bladder tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.D108Y(14)|p.?(13)|p.D108H(9)|p.D108N(5)|p.H83fs*2(2)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCCCCAGGCATCGCGCACGTC	0.741		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			23	4					0	0	0	0	A	21971035	A	A	21971035	3	1	141	1	0	0	0	0	1	0	0	0	3176	1435	50	5	155	5	CDKN2A	9	21971035	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08		21971035	119242396	284	25559											
TAF1L	138474	broad.mit.edu	37	chr9	32633172	32633172	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaaacaagggacactgctgGccaaccacaaaaatatccac	17	5	6	13	0	1	0	1	0	0	0	2	1	2	1	3	2	3	1	3	2	6	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:32633172G>A	uc003zrg.1	-	1	2496	c.2406C>T	c.(2404-2406)GGC>GGT	p.G802G	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	802					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GACACTGCTGGCCAACCACAA	0.423													53	112					0	0	0	0	A	32633172	A	A	32633172	2	1	141	1	0	0	0	0	0	0	0	1	15589	1190	42	4		4	TAF1L	9	32633172	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	10662137	32633172	108580259	285	25560											
FOXB2	442425	broad.mit.edu	37	chr9	79634859	79634859	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accccgactgcggggacatgTtcgagaacggcagcttcctg	8	7	13	13	4	0	1	0	0	0	1	2	4	1	2	3	3	3	3	3	3	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:79634859T>A	uc004ako.1	+	1	289	c.289T>A	c.(289-291)TTC>ATC	p.F97I		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	97	Fork-head.				brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CGGGGACATGTTCGAGAACGG	0.652													26	35					0	0	0	0	A	79634859	A	A	79634859	3	1	141	1	0	0	0	0	1	0	0	0	6025	1725	60	5	291	5	FOXB2	9	79634859	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	47001687	79634859	61578572	286	25561											
FLJ46321	389763	broad.mit.edu	37	chr9	84609214	84609214	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagcccagggtccctaccTgtgtcttacagaagtgtcaa	10	9	11	11	0	2	1	1	0	1	1	3	2	3	2	3	2	3	0	3	2	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:84609214T>A	uc004amn.2	+	4	3876	c.3829T>A	c.(3829-3831)TGT>AGT	p.C1277S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1277						integral to membrane					0						GGTCCCTACCTGTGTCTTACA	0.552													38	46					0	0	0	0	A	84609214	A	A	84609214	3	1	141	1	0	0	0	0	1	0	0	0	5964	1580	55	5	3843	5	FLJ46321	9	84609214	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	4974355	84609214	56604217	287	25562											
TBC1D2	55357	broad.mit.edu	37	chr9	101017708	101017708	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggaccgcctccagggacCgggcgcagtcccccgattct	5	6	14	16	4	1	0	0	0	1	0	3	3	3	2	6	4	0	1	6	4	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:101017708C>G	uc011lvb.1	-	1	296	c.116G>C	c.(115-117)CGG>CCG	p.R39P	TBC1D2_uc004ayq.2_Missense_Mutation_p.R39P|TBC1D2_uc004ayr.2_5'UTR|TBC1D2_uc004ayo.3_Missense_Mutation_p.R39P	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	39	Interaction with CADH1.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		CTCCAGGGACCGGGCGCAGTC	0.637													14	30					0	0	0	0	G	101017708	G	G	101017708	3	3	141	1	0	0	0	0	1	0	0	0	15674	652	23	3	2689	3	TBC1D2	9	101017708	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	16408494	101017708	40195723	288	25563											
COL15A1	1306	broad.mit.edu	37	chr9	101749627	101749627	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accccaggactcccgaggagCtgtgtgaccctgaagagtcc	9	6	12	14	1	0	3	0	2	0	1	2	6	2	5	5	2	1	1	5	2	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:101749627C>A	uc004azb.1	+	4	906	c.700C>A	c.(700-702)CTG>ATG	p.L234M		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	234	Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TCCCGAGGAGCTGTGTGACCC	0.642													21	160					1.55795e-14	2.05391e-14	1	0	A	101749627	A	A	101749627	3	1	141	1	0	0	0	0	1	0	0	0	3687	796	28	4	714	4	COL15A1	9	101749627	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	731919	101749627	39463804	289	25564											
KIF12	113220	broad.mit.edu	37	chr9	116858353	116858353	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggccagcaggcttcggttGatgctgttagcctcaagcat	8	10	13	10	1	1	1	1	1	0	0	2	1	1	1	2	3	4	6	2	3	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:116858353G>C	uc004bif.2	-	6	697	c.459C>G	c.(457-459)ATC>ATG	p.I153M	KIF12_uc004big.2_RNA	NM_138424	NP_612433	Q96FN5	KIF12_HUMAN	kinesin family member 12	286	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GGCTTCGGTTGATGCTGTTAG	0.617													39	68					0	0	0	0	C	116858353	C	C	116858353	3	2	141	1	0	0	0	0	1	0	0	0	8312	1280	45	2	1126	2	KIF12	9	116858353	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	15108726	116858353	24355078	290	25565											
TLR4	7099	broad.mit.edu	37	chr9	120476132	120476132	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagtctagctttcttaaatCttactcagaatgactttgct	10	17	6	8	0	4	2	1	1	3	1	4	2	4	2	0	0	3	3	0	0	6	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:120476132C>A	uc004bjz.2	+	3	2017	c.1726C>A	c.(1726-1728)CTT>ATT	p.L576I	TLR4_uc004bka.2_Missense_Mutation_p.L536I|TLR4_uc004bkb.2_Missense_Mutation_p.L376I	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	576	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTTCTTAAATCTTACTCAGAA	0.413													17	34					0.000422831	0.000447237	1	0	A	120476132	A	A	120476132	3	1	141	1	0	0	0	0	1	0	0	0	16019	913	32	2	1736	2	TLR4	9	120476132	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3617779	120476132	20737299	291	25566											
SPTAN1	6709	broad.mit.edu	37	chr9	131331097	131331097	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaagctgaagtgcaggccaActcaggagccattgttaagc	12	8	12	9	0	1	2	1	2	0	0	1	3	1	3	2	2	5	3	2	2	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:131331097A>T	uc004bvl.3	+	3	397	c.284A>T	c.(283-285)AAC>ATC	p.N95I	SPTAN1_uc011mbg.1_Missense_Mutation_p.N95I|SPTAN1_uc011mbh.1_Missense_Mutation_p.N107I|SPTAN1_uc004bvm.3_Missense_Mutation_p.N95I|SPTAN1_uc004bvn.3_Missense_Mutation_p.N95I	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	95	Spectrin 2.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GTGCAGGCCAACTCAGGAGCC	0.488													54	9					0	0	0	0	T	131331097	T	T	131331097	3	4	141	1	0	0	0	0	1	0	0	0	15183	43	2	5	290	5	SPTAN1	9	131331097	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	10854965	131331097	9882334	292	25567											
RXRA	6256	broad.mit.edu	37	chr9	137293648	137293648	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcatgggcccgcctttctcgGtcatcagctcccccatgggc	4	9	11	17	2	3	0	2	0	1	0	5	0	4	0	4	3	1	2	4	3	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:137293648G>T	uc004cfb.2	+	2	361	c.199G>T	c.(199-201)GTC>TTC	p.V67F	RXRA_uc004cfa.1_Missense_Mutation_p.G117V	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	67	Modulating (By similarity).				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCCTTTCTCGGTCATCAGCTC	0.647													124	40					4.56963e-79	7.29746e-79	1	0	T	137293648	T	T	137293648	3	4	141	1	0	0	0	0	1	0	0	0	13828	1261	44	4	205	4	RXRA	9	137293648	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	5962551	137293648	3919783	293	25568											
OLFM1	10439	broad.mit.edu	37	chr9	137998625	137998625	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gttgacgggcatcagtgaccCcgtgactgtcaagacctccg	8	8	12	13	3	2	4	2	3	0	1	3	4	3	4	4	1	0	2	4	1	1	1	rs146984036		TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:137998625C>A	uc010nar.2	+	5	1023	c.707C>A	c.(706-708)CCC>CAC	p.P236H	OLFM1_uc004cfl.3_Missense_Mutation_p.P218H|OLFM1_uc004cfn.3_5'UTR	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	236	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding	p.P218L(1)		ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		ATCAGTGACCCCGTGACTGTC	0.527													15	10					3.41278e-10	4.14854e-10	1	0	A	137998625	A	A	137998625	3	1	141	1	0	0	0	0	1	0	0	0	10906	623	22	4	681	4	OLFM1	9	137998625	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	704977	137998625	3214806	294	25569											
SNAPC4	6621	broad.mit.edu	37	chr9	139282935	139282935	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgccgacgcgcatctcctGcaccagctgcgtgagcatgc	6	7	12	16	4	1	1	0	1	1	0	2	2	1	1	3	0	6	5	3	0	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:139282935G>T	uc004chh.2	-	10	1093	c.1084C>A	c.(1084-1086)CAG>AAG	p.Q362K		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	362	Myb-like 2.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CGCATCTCCTGCACCAGCTGC	0.622													14	46					9.31168e-06	1.02331e-05	1	0	T	139282935	T	T	139282935	3	4	141	1	0	0	0	0	1	0	0	0	14901	1328	46	4	3377	4	SNAPC4	9	139282935	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1284310	139282935	1930496	295	25570											
LARP4B	23185	broad.mit.edu	37	chr10	875449	875449	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgacgtcgcgtagcgctgcTgggcatacaggctcacgtcc	7	7	13	14	6	1	0	1	0	0	0	3	1	2	0	1	2	3	5	1	2	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:875449T>A	uc001ifs.1	-	10	1042	c.1001A>T	c.(1000-1002)CAG>CTG	p.Q334L		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	334							nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						GTAGCGCTGCTGGGCATACAG	0.517													38	19					0	0	0	0	A	875449	A	A	875449	3	1	141	1	0	0	0	0	1	0	0	0	8671	1580	55	5	1247	5	LARP4B	10	875449	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08		875449	134659298	296	25571											
NET1	10276	broad.mit.edu	37	chr10	5498668	5498668	+	Frame_Shift_Del	DEL	C	-	-																															ctgtattcgagcggccattgCccccttccagtcggcaggca																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:5498668delC	uc001iia.2	+	12	1640	c.1502delC	c.(1501-1503)GCCfs	p.A501fs	NET1_uc010qar.1_Frame_Shift_Del_p.A320fs|NET1_uc001iib.2_Frame_Shift_Del_p.A447fs|NET1_uc010qas.1_Frame_Shift_Del_p.A320fs	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	501	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						GCGGCCATTGCCCCCTTCCAG	0.602													---	---	---								-	5498668	-	-	5498668	7	5	141	1	0	1	0	1	0	0	0	0	10392	739	26	0	1645	0	NET1	10	5498668	Frame_Shift_Del	DEL	C	TCGA-CR-7370-01A-11D-2129-08	4623219	5498668	130036079	297	25572											
TAF3	83860	broad.mit.edu	37	chr10	8006089	8006089	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcactaaaggggacacgctaGatgttgtgttattggaagct	11	11	13	6	1	0	1	0	0	0	1	0	3	0	3	0	3	1	5	0	3	5	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:8006089G>A	uc010qbd.1	+	3	616	c.616G>A	c.(616-618)GAT>AAT	p.D206N		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	206					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						GGACACGCTAGATGTTGTGTT	0.478													36	28					0	0	0	0	A	8006089	A	A	8006089	3	1	141	1	0	0	0	0	1	0	0	0	15591	942	33	2	626	2	TAF3	10	8006089	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2507421	8006089	127528658	298	25573											
ARMC3	219681	broad.mit.edu	37	chr10	23248003	23248003	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcttcctttgtagatgaTgttaaaaaattgttaaggga	12	17	9	3	0	1	2	0	1	1	1	2	3	2	3	1	1	0	4	1	1	5	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:23248003T>A	uc001irm.3	+	5	380	c.297T>A	c.(295-297)GAT>GAA	p.D99E	ARMC3_uc010qcv.1_Missense_Mutation_p.D99E|ARMC3_uc010qcw.1_5'UTR|ARMC3_uc001irn.1_Missense_Mutation_p.D11E	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	99	ARM 3.						binding				0						TTGTAGATGATGTTAAAAAAT	0.229													30	27					0	0	0	0	A	23248003	A	A	23248003	3	1	141	1	0	0	0	0	1	0	0	0	954	1461	51	5	311	5	ARMC3	10	23248003	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	15241914	23248003	112286744	299	25574											
PARD3	56288	broad.mit.edu	37	chr10	34671813	34671813	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccacatggaaccaaatgaTgggtgtacgcatggcttggc	12	8	12	9	1	0	1	0	1	0	0	0	2	0	2	2	4	3	3	2	4	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:34671813T>C	uc010qej.1	-	9	1054	c.1054A>G	c.(1054-1056)ATC>GTC	p.I352V	PARD3_uc010qek.1_Missense_Mutation_p.I352V|PARD3_uc010qel.1_Missense_Mutation_p.I352V|PARD3_uc010qem.1_Missense_Mutation_p.I352V|PARD3_uc010qen.1_Missense_Mutation_p.I352V|PARD3_uc010qeo.1_Missense_Mutation_p.I352V|PARD3_uc010qep.1_Missense_Mutation_p.I308V|PARD3_uc010qeq.1_Missense_Mutation_p.I308V|PARD3_uc001ixo.1_Missense_Mutation_p.I82V|PARD3_uc001ixp.1_Missense_Mutation_p.I217V|PARD3_uc001ixq.1_Missense_Mutation_p.I352V|PARD3_uc001ixr.1_Missense_Mutation_p.I352V|PARD3_uc001ixt.1_Missense_Mutation_p.I173V|PARD3_uc001ixu.1_Missense_Mutation_p.I308V|PARD3_uc001ixs.1_Missense_Mutation_p.I5V	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	352	PDZ 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				AACCAAATGATGGGTGTACGC	0.398													66	50					0	0	0	0	C	34671813	C	C	34671813	3	2	141	1	0	0	0	0	1	0	0	0	11497	1464	51	5	3119	5	PARD3	10	34671813	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	11423810	34671813	100862934	300	25575											
ZNF32	7580	broad.mit.edu	37	chr10	44140211	44140211	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttgaggatcctgtagcctCagagtggtcatatttgtggt	7	14	13	7	0	2	2	2	1	0	1	3	3	3	3	2	3	1	2	2	3	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:44140211C>T	uc001jbb.2	-	3	298	c.109G>A	c.(109-111)GAG>AAG	p.E37K	uc001jba.2_Intron|ZNF32_uc001jbc.2_Missense_Mutation_p.E37K	NM_001005368	NP_001005368	P17041	ZNF32_HUMAN	zinc finger protein 32	37					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		all_neural(218;0.0182)|Ovarian(717;0.0443)|Renal(717;0.157)		Lung(62;0.179)		CCTGTAGCCTCAGAGTGGTCA	0.418													14	90					0	0	0	0	T	44140211	T	T	44140211	3	4	141	1	0	0	0	0	1	0	0	0	17905	835	29	2	716	2	ZNF32	10	44140211	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	9468398	44140211	91394536	301	25576											
CHAT	1103	broad.mit.edu	37	chr10	50863176	50863176	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcccacctacgagagcgCgtccatccgccgattccagg	7	6	12	16	5	0	1	0	0	0	1	3	3	3	1	6	2	3	0	6	2	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:50863176C>T	uc001jhz.2	+	12	1823	c.1670C>T	c.(1669-1671)GCG>GTG	p.A557V	CHAT_uc001jhv.1_Missense_Mutation_p.A439V|CHAT_uc001jhx.1_Missense_Mutation_p.A439V|CHAT_uc001jhy.1_Missense_Mutation_p.A439V|CHAT_uc001jia.2_Missense_Mutation_p.A439V|CHAT_uc010qgs.1_Missense_Mutation_p.A439V	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	557					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TACGAGAGCGCGTCCATCCGC	0.547													15	45					0	0	0	0	T	50863176	T	T	50863176	3	4	141	1	0	0	0	0	1	0	0	0	3328	768	27	1	1760	1	CHAT	10	50863176	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	6722965	50863176	84671571	302	25577											
DUPD1	338599	broad.mit.edu	37	chr10	76803730	76803730	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggccgcgttcagcacgtgCgtgaaccccgccttctgcag	5	8	13	15	5	2	1	1	1	1	0	2	1	2	1	4	1	4	3	4	1	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:76803730C>T	uc001jwq.1	-	2	246	c.246G>A	c.(244-246)ACG>ACA	p.T82T		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	82	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TCAGCACGTGCGTGAACCCCG	0.711													13	13					0	0	0	0	T	76803730	T	T	76803730	2	4	141	1	0	0	0	0	0	0	0	1	4826	755	27	1		1	DUPD1	10	76803730	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	25940554	76803730	58731017	303	25578											
MAT1A	4143	broad.mit.edu	37	chr10	82039969	82039969	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcagccaggggaggaggccgGagcgcctgaggtctgccatc	7	4	18	12	2	1	1	0	1	1	0	2	4	1	4	4	6	3	1	4	6	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:82039969G>C	uc001kbw.2	-	5	764	c.509C>G	c.(508-510)TCC>TGC	p.S170C		NM_000429	NP_000420	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	170					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	GAGGAGGCCGGAGCGCCTGAG	0.577													48	29					0	0	0	0	C	82039969	C	C	82039969	3	2	141	1	0	0	0	0	1	0	0	0	9382	1174	41	2	698	2	MAT1A	10	82039969	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	5236239	82039969	53494778	304	25579											
GRID1	2894	broad.mit.edu	37	chr10	87614373	87614373	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaggccagtgatgtggccCtgcagaagaggagaaaaacc	13	5	15	8	0	0	5	0	2	0	3	0	6	0	5	3	3	2	1	3	3	3	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:87614373C>A	uc001kdl.1	-	8	1215	c.1114_splice	c.e8-1	p.G372_splice	GRID1_uc009xsu.1_Splice_Site	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1							cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TGATGTGGCCCTGCAGAAGAG	0.498										Multiple Myeloma(13;0.14)			23	9					5.35356e-11	6.63986e-11	1	0	A	87614373	A	A	87614373	5	1	141	1	0	0	0	0	0	0	1	0	6810	695	24	4	1952	4	GRID1	10	87614373	Splice_Site	SNP	C	TCGA-CR-7370-01A-11D-2129-08	5574404	87614373	47920374	305	25580											
OPALIN	93377	broad.mit.edu	37	chr10	98105775	98105775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatagtaggacggtaacggtCatgcacaggttcctcgcttc	9	11	11	10	3	1	0	1	0	0	0	4	1	2	1	1	4	2	5	1	4	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:98105775C>T	uc001kmj.2	-	6	788	c.349G>A	c.(349-351)GAC>AAC	p.D117N	OPALIN_uc010qor.1_Missense_Mutation_p.D107N|OPALIN_uc001kmi.2_Missense_Mutation_p.D107N|OPALIN_uc001kmk.2_Missense_Mutation_p.D94N|OPALIN_uc010qos.1_RNA	NM_033207	NP_149984	Q96PE5	OPALI_HUMAN	transmembrane protein 10 isoform a	117						Golgi apparatus|integral to membrane|plasma membrane					0						CGGTAACGGTCATGCACAGGT	0.507													59	41					0	0	0	0	T	98105775	T	T	98105775	3	4	141	1	0	0	0	0	1	0	0	0	10927	826	29	2	80	2	OPALIN	10	98105775	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	10491402	98105775	37428972	306	25581											
GBF1	8729	broad.mit.edu	37	chr10	104120033	104120033	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacacgaccgccataactcaGaggttatgattcacatggga	13	8	9	11	2	2	2	2	1	0	1	2	4	2	3	2	2	1	1	2	2	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:104120033G>A	uc001kux.1	+	12	1510	c.1270G>A	c.(1270-1272)GAG>AAG	p.E424K	GBF1_uc001kuw.2_3'UTR|GBF1_uc001kuy.1_Missense_Mutation_p.E424K|GBF1_uc001kuz.1_Missense_Mutation_p.E425K	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	424					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CCATAACTCAGAGGTTATGAT	0.562													183	89					0	0	0	0	A	104120033	A	A	104120033	3	1	141	1	0	0	0	0	1	0	0	0	6306	943	33	2	1312	2	GBF1	10	104120033	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	6014258	104120033	31414714	307	25582											
TRIM8	81603	broad.mit.edu	37	chr10	104416663	104416663	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcggccagtacggggcggCgggcacagccagcggtgagg	6	2	22	11	5	0	1	0	1	0	0	0	1	0	1	2	8	3	2	2	8	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:104416663C>T	uc001kvz.2	+	6	1331	c.1208C>T	c.(1207-1209)GCG>GTG	p.A403V		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	403						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		TACGGGGCGGCGGGCACAGCC	0.711													38	23					0	0	0	0	T	104416663	T	T	104416663	3	4	141	1	0	0	0	0	1	0	0	0	16615	768	27	1	1230	1	TRIM8	10	104416663	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	296630	104416663	31118084	308	25583											
GFRA1	2674	broad.mit.edu	37	chr10	117885028	117885028	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgtcgaggttgcaggccttCgctgcatccaggcagttgtt	5	12	13	11	3	0	0	0	0	0	0	4	1	1	0	2	3	2	7	2	3	0	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:117885028C>T	uc001lcj.2	-	6	1172	c.474G>A	c.(472-474)GCG>GCA	p.A158A	GFRA1_uc001lci.2_Silent_p.A153A|GFRA1_uc009xyr.2_Silent_p.A153A	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	158	2.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TGCAGGCCTTCGCTGCATCCA	0.557													4	14					0	0	0	0	T	117885028	T	T	117885028	2	4	141	1	0	0	0	0	0	0	0	1	6384	871	31	1		1	GFRA1	10	117885028	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	13468365	117885028	17649719	309	25584											
IRF7	3665	broad.mit.edu	37	chr11	613308	613308	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcctgggggtccgcccacctCccagtacaccttgcacttgc	5	8	10	18	1	0	0	0	0	0	0	2	0	2	0	6	2	3	2	6	2	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:613308C>T	uc001lqh.2	-	9	1505	c.1135G>A	c.(1135-1137)GAG>AAG	p.E379K	IRF7_uc009ycb.2_Missense_Mutation_p.E273K|IRF7_uc010qwf.1_Missense_Mutation_p.E378K|IRF7_uc001lqf.2_Missense_Mutation_p.E86K|IRF7_uc010qwg.1_Missense_Mutation_p.E86K|IRF7_uc001lqg.2_Missense_Mutation_p.E392K|IRF7_uc001lqi.2_Missense_Mutation_p.E350K|IRF7_uc010qwh.1_Missense_Mutation_p.E86K	NM_001572	NP_001563	Q92985	IRF7_HUMAN	interferon regulatory factor 7 isoform a	379					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCGCCCACCTCCCAGTACACC	0.677													13	32					0	0	0	0	T	613308	T	T	613308	3	4	141	1	0	0	0	0	1	0	0	0	7874	864	30	2	388	2	IRF7	11	613308	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08		613308	134393208	310	25585											
MRGPRE	116534	broad.mit.edu	37	chr11	3249862	3249862	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggaggtagatggcgaagggGtttctgtagacattggagct	10	10	17	4	1	1	2	0	0	1	2	1	5	1	4	0	6	1	4	0	6	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:3249862G>A	uc001lxq.3	-	2	475	c.165C>T	c.(163-165)AAC>AAT	p.N55N		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	55	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCGAAGGGGTTTCTGTAGA	0.632													41	65					0	0	0	0	A	3249862	A	A	3249862	2	1	141	1	0	0	0	0	0	0	0	1	9817	1252	44	4		4	MRGPRE	11	3249862	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2636554	3249862	131756654	311	25586											
OR52K2	119774	broad.mit.edu	37	chr11	4470788	4470788	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgttggcagccatcgacctGgtcctttcctcctcagcact	6	12	8	15	1	1	0	1	0	0	0	5	1	4	0	5	2	2	3	5	2	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:4470788G>T	uc001lyz.1	+	1	219	c.219G>T	c.(217-219)CTG>CTT	p.L73L		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATCGACCTGGTCCTTTCCT	0.527													74	107					4.12397e-46	6.45913e-46	1	0	T	4470788	T	T	4470788	2	4	141	1	0	0	0	0	0	0	0	1	11178	1335	47	4		4	OR52K2	11	4470788	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1220926	4470788	130535728	312	25587											
OR52A5	390054	broad.mit.edu	37	chr11	5153170	5153170	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaaggccttgaatcgtgcctCcttctggggcagctgaaaga	10	9	12	10	1	1	3	0	2	1	1	3	3	2	3	3	3	2	2	3	3	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:5153170C>T	uc010qyx.1	-	1	703	c.703G>A	c.(703-705)GAG>AAG	p.E235K		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AATCGTGCCTCCTTCTGGGGC	0.418													48	47					0	0	0	0	T	5153170	T	T	5153170	3	4	141	1	0	0	0	0	1	0	0	0	11164	864	30	2	250	2	OR52A5	11	5153170	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	682382	5153170	129853346	313	25588											
OR51B6	390058	broad.mit.edu	37	chr11	5373014	5373014	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcacagggagattggccatGgagcctgcttctctcaggcc	8	9	12	12	0	3	1	2	0	1	1	4	3	3	2	3	4	2	1	3	4	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:5373014G>T	uc010qzb.1	+	1	277	c.277G>T	c.(277-279)GGA>TGA	p.G93*	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATTGGCCATGGAGCCTGCTT	0.483													52	62					7.06795e-37	1.0884e-36	1	0	T	5373014	T	T	5373014	4	4	141	1	0	0	0	0	0	1	0	0	11146	1349	47	4	279	4	OR51B6	11	5373014	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	219844	5373014	129633502	314	25589											
OR52D1	390066	broad.mit.edu	37	chr11	5510563	5510563	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaactgtggctctgctggcCatgggactggattccattct	6	13	11	11	0	2	0	0	0	2	0	3	2	3	2	2	4	2	2	2	4	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:5510563C>A	uc010qzg.1	+	1	627	c.627C>A	c.(625-627)GCC>GCA	p.A209A	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCTGCTGGCCATGGGACTGG	0.483													93	167					1.10192e-24	1.62517e-24	1	0	A	5510563	A	A	5510563	2	1	141	1	0	0	0	0	0	0	0	1	11168	581	21	4		4	OR52D1	11	5510563	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	137549	5510563	129495953	315	25590											
OR10A4	283297	broad.mit.edu	37	chr11	6898646	6898647	+	Missense_Mutation	DNP	CA	AT	AT																															tctctcttctatagcactgcCatcctcacgtatttccgacc																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:6898646_6898647CA>AT	uc010rat.1	+	1	768_769	c.768_769CA>AT	c.(766-771)GCCATC>GCATTC	p.I257F		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATAGCACTGCCATCCTCACGTA	0.525													53	71					0	0	0	0	AT	6898647	AT	AT	6898646	3	1	141	1	0	0	0	0	1	0	0	0	10946	581	21	4	770	4	OR10A4	11	6898646	Missense_Mutation	DNP	CA	TCGA-CR-7370-01A-11D-2129-08	1388083	6898646	128107870	316	25591											
RIC3	79608	broad.mit.edu	37	chr11	8132424	8132424	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccaagacagcaggatcctCgtcttcatgaaaacagcagg	13	7	10	11	1	2	2	1	1	1	1	4	3	3	3	2	2	4	2	2	2	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:8132424C>T	uc001mgd.2	-	6	985	c.931G>A	c.(931-933)GAG>AAG	p.E311K	RIC3_uc001mgb.2_Missense_Mutation_p.E149K|RIC3_uc001mgc.2_Missense_Mutation_p.E310K|RIC3_uc001mge.2_Missense_Mutation_p.E129K|RIC3_uc010rbl.1_Missense_Mutation_p.E261K|RIC3_uc010rbm.1_Missense_Mutation_p.E339K|RIC3_uc009yfm.2_Missense_Mutation_p.E230K|RIC3_uc009yfn.2_Missense_Mutation_p.E114K	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	311	Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		GCAGGATCCTCGTCTTCATGA	0.483													80	94					0	0	0	0	T	8132424	T	T	8132424	3	4	141	1	0	0	0	0	1	0	0	0	13419	893	31	1	182	1	RIC3	11	8132424	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1233778	8132424	126874092	317	25592											
C11orf16	56673	broad.mit.edu	37	chr11	8947492	8947492	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccctagcagagagcagcaaGgggcccagtgaaggggcctg	10	3	17	11	0	0	2	0	1	0	1	0	3	0	2	3	4	3	3	3	4	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:8947492G>A	uc001mhb.3	-	5	846	c.722C>T	c.(721-723)CCT>CTT	p.P241L	C11orf16_uc001mhc.3_Missense_Mutation_p.P241L	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	241										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		AGAGCAGCAAGGGGCCCAGTG	0.612													14	91					0	0	0	0	A	8947492	A	A	8947492	3	1	141	1	0	0	0	0	1	0	0	0	1637	1000	35	4	689	4	C11orf16	11	8947492	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	815068	8947492	126059024	318	25593											
MRGPRX3	117195	broad.mit.edu	37	chr11	18158862	18158862	+	Frame_Shift_Del	DEL	C	-	-																															ggggctgacgtgcatcgtttCccttgtcgcgctgacaggaa																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:18158862delC	uc001mnu.2	+	3	474	c.113delC	c.(112-114)TCCfs	p.S38fs		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	38	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						TGCATCGTTTCCCTTGTCGCG	0.592													---	---	---								-	18158862	-	-	18158862	7	5	141	1	0	1	0	1	0	0	0	0	9821	855	30	0	115	0	MRGPRX3	11	18158862	Frame_Shift_Del	DEL	C	TCGA-CR-7370-01A-11D-2129-08	9211370	18158862	116847654	319	25594											
PRMT3	10196	broad.mit.edu	37	chr11	20483570	20483570	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttgtagcagtgagtgatGtgaataaacatgctgataga	13	11	12	5	0	0	5	0	4	0	1	0	5	0	5	1	0	3	3	1	0	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:20483570G>A	uc001mqb.2	+	12	1334	c.1117G>A	c.(1117-1119)GTG>ATG	p.V373M	PRMT3_uc001mqc.2_Missense_Mutation_p.V296M|PRMT3_uc010rdn.1_Missense_Mutation_p.V311M	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1	373							zinc ion binding				0						AGTGAGTGATGTGAATAAACA	0.388													43	91					0	0	0	0	A	20483570	A	A	20483570	3	1	141	1	0	0	0	0	1	0	0	0	12600	1377	48	4	1163	4	PRMT3	11	20483570	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2324708	20483570	114522946	320	25595											
ANO5	203859	broad.mit.edu	37	chr11	22242683	22242683	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagattctatcttcttccGagatgggattaggcaaattg	12	13	9	7	1	3	2	0	0	3	2	4	4	4	3	1	2	0	1	1	2	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:22242683G>T	uc001mqi.2	+	5	538	c.221G>T	c.(220-222)CGA>CTA	p.R74L	ANO5_uc001mqj.2_Missense_Mutation_p.R73L	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	74	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						ATCTTCTTCCGAGATGGGATT	0.353													23	32					1.17739e-12	1.51409e-12	1	0	T	22242683	T	T	22242683	3	4	141	1	0	0	0	0	1	0	0	0	700	1058	37	3	239	3	ANO5	11	22242683	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1759113	22242683	112763833	321	25596											
IMMP1L	196294	broad.mit.edu	37	chr11	31484808	31484808	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtcgaaaggttttccccaGaacaccacgaagcatagttc	14	8	8	11	2	0	1	0	0	0	1	3	3	1	1	3	1	2	3	3	1	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:31484808G>A	uc001msy.1	-	3	212	c.16C>T	c.(16-18)CTG>TTG	p.L6L	IMMP1L_uc001msz.1_Silent_p.L6L|IMMP1L_uc009yjo.2_Silent_p.L6L|IMMP1L_uc009yjp.2_Intron	NM_144981	NP_659418	Q96LU5	IMP1L_HUMAN	IMP1 inner mitochondrial membrane	6					proteolysis	mitochondrial inner membrane	serine-type peptidase activity				0	Lung SC(675;0.225)					GTTTTCCCCAGAACACCACGA	0.363													6	79					0	0	0	0	A	31484808	A	A	31484808	2	1	141	1	0	0	0	0	0	0	0	1	7755	933	33	2		2	IMMP1L	11	31484808	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	9242125	31484808	103521708	322	25597											
ALX4	60529	broad.mit.edu	37	chr11	44286554	44286554	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaaacaggctgcccatgtgCgtctggcccacgtgactgcc	7	7	11	16	2	1	1	0	1	1	0	1	1	1	1	4	2	4	1	4	2	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:44286554C>T	uc001myb.2	-	4	1190	c.1086G>A	c.(1084-1086)ACG>ACA	p.T362T		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	362					hair follicle development						0						TGCCCATGTGCGTCTGGCCCA	0.677													12	41					0	0	0	0	T	44286554	T	T	44286554	2	4	141	1	0	0	0	0	0	0	0	1	558	755	27	1		1	ALX4	11	44286554	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	12801746	44286554	90719962	323	25598											
ZNF408	79797	broad.mit.edu	37	chr11	46726538	46726538	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acctcaaagagcaccaggtgGtacattcaggtgcccggccc	10	6	11	14	1	2	1	2	0	0	1	2	1	2	1	4	4	3	2	4	4	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:46726538G>C	uc001nde.1	+	5	1518	c.1288G>C	c.(1288-1290)GTA>CTA	p.V430L	ZNF408_uc010rgw.1_Missense_Mutation_p.V422L	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	430	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						GCACCAGGTGGTACATTCAGG	0.647													26	66					0	0	0	0	C	46726538	C	C	46726538	3	2	141	1	0	0	0	0	1	0	0	0	17955	1261	44	4	1338	4	ZNF408	11	46726538	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2439984	46726538	88279978	324	25599											
C1QTNF4	114900	broad.mit.edu	37	chr11	47611622	47611622	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctcgtcgcggttcttcatCagcttaaccgacagcgtctt	7	12	8	14	5	4	0	2	0	2	0	6	1	4	0	2	1	3	2	2	1	1	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:47611622C>T	uc001ngc.2	-	2	1008	c.741G>A	c.(739-741)CTG>CTA	p.L247L		NM_031909	NP_114115	Q9BXJ3	C1QT4_HUMAN	C1q and tumor necrosis factor related protein 4	247	C1q 2.					extracellular region					0						GGTTCTTCATCAGCTTAACCG	0.677													11	20					0	0	0	0	T	47611622	T	T	47611622	2	4	141	1	0	0	0	0	0	0	0	1	1974	813	29	2		2	C1QTNF4	11	47611622	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	885084	47611622	87394894	325	25600											
OR4S1	256148	broad.mit.edu	37	chr11	48327915	48327915	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctggtcatcatcaccatCaatgctagaaagaccctgaa	13	10	6	12	0	5	3	4	1	1	2	5	3	5	3	2	1	1	1	2	1	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:48327915C>A	uc010rhu.1	+	1	141	c.141C>A	c.(139-141)ATC>ATA	p.I47I		NM_001004725	NP_001004725	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCATCACCATCAATGCTAGAA	0.448													69	88					6.12789e-21	8.68809e-21	1	0	A	48327915	A	A	48327915	2	1	141	1	0	0	0	0	0	0	0	1	11136	816	29	2		2	OR4S1	11	48327915	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	716293	48327915	86678601	326	25601											
OR4P4	81300	broad.mit.edu	37	chr11	55405873	55405873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcactttgtttattctcttgGggttttcccaaaataagaac	10	16	7	8	0	1	1	0	0	1	1	3	1	2	1	1	2	1	3	1	2	5	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:55405873G>A	uc010rij.1	+	1	40	c.40G>A	c.(40-42)GGG>AGG	p.G14R		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TATTCTCTTGGGGTTTTCCCA	0.313													75	112					0	0	0	0	A	55405873	A	A	55405873	3	1	141	1	0	0	0	0	1	0	0	0	11134	1232	43	4	42	4	OR4P4	11	55405873	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	7077958	55405873	79600643	327	25602											
SPRYD5	84767	broad.mit.edu	37	chr11	55658943	55658943	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttaccacctccccacttgtGgtgcaatatgttccaagacc	9	12	6	14	0	0	1	0	0	0	1	2	1	2	1	6	1	2	2	6	1	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:55658943G>T	uc010rip.1	+	7	1286	c.1194G>T	c.(1192-1194)GTG>GTT	p.V398V	SPRYD5_uc010riq.1_Silent_p.V255V	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	398	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CCCCACTTGTGGTGCAATATG	0.448													24	41					7.26314e-15	9.59258e-15	1	0	T	55658943	T	T	55658943	2	4	141	1	0	0	0	0	0	0	0	1	15177	1335	47	4		4	SPRYD5	11	55658943	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	253070	55658943	79347573	328	25603											
OR5W2	390148	broad.mit.edu	37	chr11	55681386	55681386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagagtgtatctccaagaCtgataggatgatataacaat	16	10	9	6	0	1	4	0	2	1	2	2	5	1	5	1	1	2	2	1	1	6	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:55681386C>T	uc010rir.1	-	1	673	c.673G>A	c.(673-675)GTC>ATC	p.V225I		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATCTCCAAGACTGATAGGATG	0.403													20	45					0	0	0	0	T	55681386	T	T	55681386	3	4	141	1	0	0	0	0	1	0	0	0	11239	565	20	4	261	4	OR5W2	11	55681386	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	22443	55681386	79325130	329	25604											
OR5J2	282775	broad.mit.edu	37	chr11	55944656	55944656	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttcactgctaaagctgtCatgttctgacacctccatga	9	13	6	13	0	3	2	2	2	1	0	5	2	5	2	3	0	2	3	3	0	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:55944656C>A	uc010rjb.1	+	1	563	c.563C>A	c.(562-564)TCA>TAA	p.S188*		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					CTAAAGCTGTCATGTTCTGAC	0.438													47	77					2.13384e-23	3.12821e-23	1	0	A	55944656	A	A	55944656	4	1	141	1	0	0	0	0	0	1	0	0	11219	838	29	2	565	2	OR5J2	11	55944656	Nonsense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	263270	55944656	79061860	330	25605											
OR8J1	219477	broad.mit.edu	37	chr11	56128446	56128446	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaaagccttttctacctgtGcttcacatatgatggcagtc	11	13	7	10	0	2	1	1	1	1	0	3	1	2	1	2	1	3	2	2	1	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:56128446G>A	uc010rjh.1	+	1	724	c.724G>A	c.(724-726)GCT>ACT	p.A242T		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TTCTACCTGTGCTTCACATAT	0.348													49	79					0	0	0	0	A	56128446	A	A	56128446	3	1	141	1	0	0	0	0	1	0	0	0	11295	1319	46	4	726	4	OR8J1	11	56128446	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	183790	56128446	78878070	331	25606											
SERPING1	710	broad.mit.edu	37	chr11	57379390	57379390	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgaccagccaggatatgctCtcaatcatggagaaattggg	13	8	11	9	1	2	1	2	0	1	1	3	4	2	2	2	3	2	1	2	3	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:57379390C>A	uc001nkp.1	+	7	1421	c.1230C>A	c.(1228-1230)CTC>CTA	p.L410L	SERPING1_uc001nkq.1_Silent_p.L373L|SERPING1_uc010rju.1_Silent_p.L358L|SERPING1_uc010rjv.1_Silent_p.L415L|SERPING1_uc001nkr.1_Silent_p.L410L|SERPING1_uc009ymi.1_Silent_p.L419L|SERPING1_uc009ymj.1_Intron|SERPING1_uc001nks.1_Silent_p.L101L	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	410					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						AGGATATGCTCTCAATCATGG	0.453									Hereditary_Angioedema				28	49					3.70037e-05	3.98878e-05	1	0	A	57379390	A	A	57379390	2	1	141	1	0	0	0	0	0	0	0	1	14181	900	32	2		2	SERPING1	11	57379390	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1250944	57379390	77627126	332	25607											
OR5B17	219965	broad.mit.edu	37	chr11	58126398	58126398	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtgtggagatgagagtccaGcaggattaatatgatcatcc	13	10	12	6	0	1	3	1	2	0	2	3	6	3	4	2	2	1	1	2	2	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:58126398G>C	uc010rke.1	-	1	145	c.145C>G	c.(145-147)CTG>GTG	p.L49V		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGAGAGTCCAGCAGGATTAAT	0.463													40	71					0	0	0	0	C	58126398	C	C	58126398	3	2	141	1	0	0	0	0	1	0	0	0	11203	962	34	4	801	4	OR5B17	11	58126398	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	747008	58126398	76880118	333	25608											
TCN1	6947	broad.mit.edu	37	chr11	59626621	59626621	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctcagacagaatcttttCtaccagtgactttgtataaa	12	16	5	8	0	3	3	1	1	3	2	4	3	3	3	1	0	1	1	1	0	5	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:59626621C>G	uc001noj.2	-	5	774	c.676G>C	c.(676-678)GAA>CAA	p.E226Q		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	226					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGAATCTTTTCTACCAGTGAC	0.413													56	105					0	0	0	0	G	59626621	G	G	59626621	3	3	141	1	0	0	0	0	1	0	0	0	15772	922	32	2	645	2	TCN1	11	59626621	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1500223	59626621	75379895	334	25609											
ZP1	22917	broad.mit.edu	37	chr11	60637115	60637115	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccaaacctgacccctccCggactctggactcccagctg	7	7	8	19	1	1	1	0	1	1	0	4	3	4	3	6	2	2	1	6	2	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:60637115C>A	uc001nqd.2	+	3	444	c.424C>A	c.(424-426)CGG>AGG	p.R142R	ZP1_uc001nqe.2_5'Flank	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	142	Extracellular (Potential).				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						TGACCCCTCCCGGACTCTGGA	0.597													20	27					3.08376e-08	3.58793e-08	1	0	A	60637115	A	A	60637115	2	1	141	1	0	0	0	0	0	0	0	1	18282	643	23	3		3	ZP1	11	60637115	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1010494	60637115	74369401	335	25610											
DDB1	1642	broad.mit.edu	37	chr11	61094321	61094321	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttattgaattccttttcTcggagagacacctcataggt	9	14	7	11	1	2	2	1	1	1	1	4	4	3	3	3	2	0	0	3	2	3	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:61094321T>A	uc001nrc.3	-	5	820	c.594A>T	c.(592-594)CGA>CGT	p.R198R	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Silent_p.R198R|DDB1_uc010rlg.1_RNA|DDB1_uc001nrd.2_Silent_p.R198R|DDB1_uc009ynl.1_Silent_p.R85R	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	198	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						ATTCCTTTTCTCGGAGAGACA	0.522								NER					97	158					0	0	0	0	A	61094321	A	A	61094321	2	1	141	1	0	0	0	0	0	0	0	1	4340	1538	54	5		5	DDB1	11	61094321	Silent	SNP	T	TCGA-CR-7370-01A-11D-2129-08	457206	61094321	73912195	336	25611											
AHNAK	79026	broad.mit.edu	37	chr11	62296993	62296993	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcccttcaacttcccttcTggaccttcaatatcaatatc	9	13	5	14	0	4	0	3	0	1	0	6	1	5	1	3	2	1	0	3	2	5	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:62296993T>C	uc001ntl.2	-	5	5196	c.4896A>G	c.(4894-4896)CCA>CCG	p.P1632P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1632					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACTTCCCTTCTGGACCTTCAA	0.473													99	142					0	0	0	0	C	62296993	C	C	62296993	2	2	141	1	0	0	0	0	0	0	0	1	414	1567	55	5		5	AHNAK	11	62296993	Silent	SNP	T	TCGA-CR-7370-01A-11D-2129-08	1202672	62296993	72709523	337	25612											
NRXN2	9379	broad.mit.edu	37	chr11	64415749	64415749	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagtcgcaggtgaagccatcCcactgctgcaagcagacgcc	10	5	11	15	2	0	2	0	1	0	1	2	2	1	2	3	1	4	4	3	1	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:64415749C>A	uc001oar.2	-	18	3784	c.3345G>T	c.(3343-3345)TGG>TGT	p.W1115C	NRXN2_uc001oas.2_Missense_Mutation_p.W1075C|NRXN2_uc001oaq.2_Missense_Mutation_p.W782C	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						TGAAGCCATCCCACTGCTGCA	0.627													34	62					1.62565e-12	2.08322e-12	1	0	A	64415749	A	A	64415749	3	1	141	1	0	0	0	0	1	0	0	0	10720	624	22	4	2090	4	NRXN2	11	64415749	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2118756	64415749	70590767	338	25613											
ANKRD13D	338692	broad.mit.edu	37	chr11	67068516	67068516	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgctctccctgggtgaccagGtgacccccatcatcgaccta	7	8	9	17	2	2	2	1	2	1	0	4	3	2	2	5	2	0	1	5	2	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:67068516G>T	uc001okc.1	+	12	1379	c.868G>T	c.(868-870)GTG>TTG	p.V290L	ANKRD13D_uc001okd.1_Missense_Mutation_p.V377L|ANKRD13D_uc001oke.1_Missense_Mutation_p.V290L|ANKRD13D_uc001okg.1_Missense_Mutation_p.V73L|ANKRD13D_uc001okh.1_Missense_Mutation_p.V73L|ANKRD13D_uc001oki.1_Missense_Mutation_p.V27L|SSH3_uc001okj.2_5'Flank|SSH3_uc001okk.2_5'Flank|SSH3_uc001okl.2_5'Flank	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	290										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GGGTGACCAGGTGACCCCCAT	0.607													16	29					3.52763e-06	3.91188e-06	1	0	T	67068516	T	T	67068516	3	4	141	1	0	0	0	0	1	0	0	0	644	1261	44	4	1171	4	ANKRD13D	11	67068516	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2652767	67068516	67938000	339	25614											
TBX10	347853	broad.mit.edu	37	chr11	67399229	67399229	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cttgggatccctaggtggctCggggctccagagtacaggct	6	9	15	11	1	0	1	0	0	0	1	3	2	2	2	2	6	1	4	2	6	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:67399229C>G	uc001omp.2	-	8	1093	c.1005G>C	c.(1003-1005)CCG>CCC	p.P335P	NUDT8_uc001omn.2_5'Flank|NUDT8_uc001omo.1_5'Flank	NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	335					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CTAGGTGGCTCGGGGCTCCAG	0.652													7	12					0	0	0	0	G	67399229	G	G	67399229	2	3	141	1	0	0	0	0	0	0	0	1	15717	871	31	3		3	TBX10	11	67399229	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	330713	67399229	67607287	340	25615											
LRP5	4041	broad.mit.edu	37	chr11	68181317	68181317	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atccagggccacctggacttCgtgatggacatcctggtgtt	7	11	12	11	1	0	1	0	1	0	0	3	3	2	3	4	4	0	1	4	4	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:68181317C>T	uc001ont.2	+	12	2739	c.2664C>T	c.(2662-2664)TTC>TTT	p.F888F	LRP5_uc009ysg.2_Silent_p.F298F	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	888	Beta-propeller 3.|LDL-receptor class B 15.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						ACCTGGACTTCGTGATGGACA	0.592													27	33					0	0	0	0	T	68181317	T	T	68181317	2	4	141	1	0	0	0	0	0	0	0	1	9010	883	31	1		1	LRP5	11	68181317	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	782088	68181317	66825199	341	25616											
SHANK2	22941	broad.mit.edu	37	chr11	70332941	70332941	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acccacgaaatggttttcggGctccctgggcgtggcactcg	6	9	13	13	4	0	0	0	0	0	0	3	1	1	0	2	4	0	3	2	4	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:70332941G>T	uc001oqc.2	-	21	3535	c.3457C>A	c.(3457-3459)CCC>ACC	p.P1153T	SHANK2_uc010rqn.1_Missense_Mutation_p.P565T|SHANK2_uc001opz.2_Missense_Mutation_p.P558T|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	774					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGGTTTTCGGGCTCCCTGGGC	0.677													34	49					2.20262e-25	3.26166e-25	1	0	T	70332941	T	T	70332941	3	4	141	1	0	0	0	0	1	0	0	0	14330	1203	42	4	2100	4	SHANK2	11	70332941	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2151624	70332941	64673575	342	25617											
KRTAP5-9	3846	broad.mit.edu	37	chr11	71260116	71260116	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagccctgctgctcatcctCaggctgtgggtcatcctgct	5	11	10	15	0	3	0	3	0	0	0	5	0	5	0	3	2	4	4	3	2	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:71260116C>T	uc001oqs.1	+	1	651	c.413C>T	c.(412-414)TCA>TTA	p.S138L		NM_005553	NP_005544	P26371	KRA59_HUMAN	keratin associated protein 5-9	138	8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament					0						TGCTCATCCTCAGGCTGTGGG	0.612													93	163					0	0	0	0	T	71260116	T	T	71260116	3	4	141	1	0	0	0	0	1	0	0	0	8608	838	29	2	415	2	KRTAP5-9	11	71260116	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	927175	71260116	63746400	343	25618											
P4HA3	283208	broad.mit.edu	37	chr11	74013546	74013546	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcacattgagcatgtacacGtcctgcagccgcatcagggc	9	9	10	13	2	2	1	2	1	0	0	3	1	3	1	2	1	4	4	2	1	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:74013546G>T	uc001ouz.2	-	3	478	c.435C>A	c.(433-435)GAC>GAA	p.D145E	P4HA3_uc001ouy.3_RNA|P4HA3_uc010rrj.1_Missense_Mutation_p.D145E	NM_182904	NP_878907	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha III subunit	145						endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			skin(1)	1	Breast(11;2.31e-05)					GCATGTACACGTCCTGCAGCC	0.552													56	109					5.82218e-30	8.81747e-30	1	0	T	74013546	T	T	74013546	3	4	141	1	0	0	0	0	1	0	0	0	11412	1136	40	3	1243	3	P4HA3	11	74013546	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2753430	74013546	60992970	344	25619											
CHRDL2	25884	broad.mit.edu	37	chr11	74408263	74408263	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctaccttcgtgggggccAgcgagcagtcggaagtgctg	6	8	15	12	3	0	0	0	0	0	0	3	2	1	1	3	3	4	2	3	3	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:74408263A>G	uc001ovi.2	-	10	1453	c.1200T>C	c.(1198-1200)GCT>GCC	p.A400A	CHRDL2_uc001ovg.2_Silent_p.A284A|CHRDL2_uc001ovh.2_Missense_Mutation_p.W419R			Q6WN34	CRDL2_HUMAN	RecName: Full=Chordin-like protein 2; AltName: Full=Chordin-related protein 2; AltName: Full=Breast tumor novel factor 1;          Short=BNF-1; Flags: Precursor;	400					cartilage development|cell differentiation|ossification	extracellular region|mitochondrion					0	Hepatocellular(1;0.098)					CGTGGGGGCCAGCGAGCAGTC	0.587													40	68					0	0	0	0	G	74408263	G	G	74408263	2	3	141	1	0	0	0	0	0	0	0	1	3389	188	7	5		5	CHRDL2	11	74408263	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	394717	74408263	60598253	345	25620											
OR2AT4	341152	broad.mit.edu	37	chr11	74800700	74800700	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctctggcagagaggggatgCccaatagatagaagacgggt	12	7	15	7	1	1	4	0	0	1	4	2	6	1	5	1	4	1	1	1	4	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:74800700C>T	uc010rro.1	-	1	59	c.59G>A	c.(58-60)GGC>GAC	p.G20D		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGAGGGGATGCCCAATAGATA	0.507													28	39					0	0	0	0	T	74800700	T	T	74800700	3	4	141	1	0	0	0	0	1	0	0	0	11041	739	26	4	906	4	OR2AT4	11	74800700	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	392437	74800700	60205816	346	25621											
MMP12	4321	broad.mit.edu	37	chr11	102738033	102738033	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaaagatcttatttcccacGgtagtgacagcatcaaaact	16	10	6	9	1	2	2	1	1	1	1	3	2	3	2	1	1	2	2	1	1	6	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:102738033G>C	uc001phk.2	-	7	924	c.879C>G	c.(877-879)ACC>ACG	p.T293T		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	293	Hemopexin-like 1.				positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TATTTCCCACGGTAGTGACAG	0.368													7	3					0	0	0	0	C	102738033	C	C	102738033	2	2	141	1	0	0	0	0	0	0	0	1	9704	1103	39	3		3	MMP12	11	102738033	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	27937333	102738033	32268483	347	25622											
PIH1D2	120379	broad.mit.edu	37	chr11	111938637	111938637	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attagcgtggatttttctttGataaattttgctgtggtcat	8	20	9	4	1	2	1	1	1	1	0	2	2	2	2	0	2	2	1	0	2	3	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:111938637G>C	uc001pmq.3	-	6	988	c.906C>G	c.(904-906)ATC>ATG	p.I302M	PIH1D2_uc009yyl.2_Intron|PIH1D2_uc001pmp.3_Missense_Mutation_p.I302M	NM_138789	NP_620144	Q8WWB5	PIHD2_HUMAN	PIH1 domain containing 2 isoform 1	302										ovary(1)	1		all_cancers(61;1.09e-14)|all_epithelial(67;7.64e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.19e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;6.18e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0508)		ATTTTTCTTTGATAAATTTTG	0.333													38	33					0	0	0	0	C	111938637	C	C	111938637	3	2	141	1	0	0	0	0	1	0	0	0	11962	1280	45	2	103	2	PIH1D2	11	111938637	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	9200604	111938637	23067879	348	25623											
FAM55A	120400	broad.mit.edu	37	chr11	114393726	114393726	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actgaacctggttgcaaaatGttgttatccattttccttgt	9	17	7	8	0	0	1	0	1	0	0	2	1	2	1	3	1	2	4	3	1	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:114393726G>A	uc001ppa.2	-	5	974	c.557C>T	c.(556-558)ACA>ATA	p.T186I	FAM55A_uc010rxd.1_Missense_Mutation_p.T35I	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	328						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		GTTGCAAAATGTTGTTATCCA	0.403													19	12					0	0	0	0	A	114393726	A	A	114393726	3	1	141	1	0	0	0	0	1	0	0	0	5616	1377	48	4	668	4	FAM55A	11	114393726	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2455089	114393726	20612790	349	25624											
FAM55D	54827	broad.mit.edu	37	chr11	114453199	114453199	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccacattcagagtggactTgggaagtgccattgacaaac	12	8	12	9	0	1	2	1	1	0	1	1	4	1	4	2	3	2	0	2	3	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:114453199T>G	uc001ppc.2	-	3	822	c.641A>C	c.(640-642)CAA>CCA	p.Q214P	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	214						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		AGAGTGGACTTGGGAAGTGCC	0.512													36	28					0	0	0	0	G	114453199	G	G	114453199	3	3	141	1	0	0	0	0	1	0	0	0	5619	1812	63	5	1009	5	FAM55D	11	114453199	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	59473	114453199	20553317	350	25625											
DSCAML1	57453	broad.mit.edu	37	chr11	117299175	117299175	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgtgggcccccggctcgtgGaggctcggtgctgggggccg	1	7	21	12	4	0	0	0	0	0	0	2	1	0	1	3	7	1	3	3	7	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:117299175G>A	uc001prh.1	-	33	6213	c.6211C>T	c.(6211-6213)CCA>TCA	p.P2071S		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	2011	Cytoplasmic (Potential).|Pro-rich.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCGGCTCGTGGAGGCTCGGTG	0.746													7	6					0	0	0	0	A	117299175	A	A	117299175	3	1	141	1	0	0	0	0	1	0	0	0	4791	1174	41	2	134	2	DSCAML1	11	117299175	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2845976	117299175	17707341	351	25626											
USP2	9099	broad.mit.edu	37	chr11	119229766	119229766	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggttctcagggttggacttAggtctcagtgtcactcggtt	6	14	13	8	1	3	0	3	0	2	0	6	1	3	1	0	5	0	3	0	5	1	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:119229766A>T	uc001pwm.3	-	6	1435	c.1140T>A	c.(1138-1140)CCT>CCA	p.P380P	USP2_uc001pwl.3_Silent_p.P171P|USP2_uc001pwn.3_Silent_p.P137P	NM_004205	NP_004196	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2 isoform a	380					cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			ovary(2)|urinary_tract(1)|skin(1)	4		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		GGTTGGACTTAGGTCTCAGTG	0.483													39	15					0	0	0	0	T	119229766	T	T	119229766	2	4	141	1	0	0	0	0	0	0	0	1	17119	407	15	5		5	USP2	11	119229766	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	1930591	119229766	15776750	352	25627											
OPCML	4978	broad.mit.edu	37	chr11	132306621	132306621	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcacagctcaggatgccCttctgaccgactgaaacacc	10	8	8	15	1	3	2	2	2	1	0	3	4	3	3	3	1	3	2	3	1	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:132306621C>T	uc001qgs.2	-	5	767	c.717G>A	c.(715-717)AAG>AAA	p.K239K	OPCML_uc001qgu.2_Silent_p.K232K|OPCML_uc010sck.1_Silent_p.K239K|OPCML_uc001qgt.2_Silent_p.K238K|OPCML_uc010scl.1_Silent_p.K198K	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	239	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TCAGGATGCCCTTCTGACCGA	0.393													21	21					0	0	0	0	T	132306621	T	T	132306621	2	4	141	1	0	0	0	0	0	0	0	1	10928	680	24	4		4	OPCML	11	132306621	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	13076855	132306621	2699895	353	25628											
IGSF9B	22997	broad.mit.edu	37	chr11	133790844	133790844	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaaccgagggctgtatgctgGtggtggcaggtaggactcct	7	9	17	8	1	0	0	0	0	0	0	1	3	1	1	2	6	2	5	2	6	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:133790844G>T	uc001qgx.3	-	18	3007	c.2776C>A	c.(2776-2778)CCA>ACA	p.P926T		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	926	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTGTATGCTGGTGGTGGCAGG	0.706													32	21					2.80507e-11	3.50873e-11	1	0	T	133790844	T	T	133790844	3	4	141	1	0	0	0	0	1	0	0	0	7645	1261	44	4	1281	4	IGSF9B	11	133790844	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1484223	133790844	1215672	354	25629											
IQSEC3	440073	broad.mit.edu	37	chr12	266858	266858	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggacttcatccgaaaccttcGaggtgaggaggtgggcactg	9	8	15	9	2	1	1	1	1	0	0	3	5	2	3	2	5	1	1	2	5	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:266858G>A	uc001qhw.1	+	4	1538	c.1532G>A	c.(1531-1533)CGA>CAA	p.R511Q	IQSEC3_uc001qhu.1_Missense_Mutation_p.R511Q	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	814	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CGAAACCTTCGAGGTGAGGAG	0.587													5	57					0	0	0	0	A	266858	A	A	266858	3	1	141	1	0	0	0	0	1	0	0	0	7858	1058	37	1	2467	1	IQSEC3	12	266858	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08		266858	133585037	355	25630											
AKAP3	10566	broad.mit.edu	37	chr12	4747326	4747326	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatcaactttgcatactcCattttggctttgtaaccagt	10	15	6	10	0	1	0	1	0	0	0	2	1	2	0	2	1	4	3	2	1	3	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:4747326C>T	uc001qnb.3	-	3	266	c.37G>A	c.(37-39)GGA>AGA	p.G13R		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	13					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						TTGCATACTCCATTTTGGCTT	0.408													44	149					0	0	0	0	T	4747326	T	T	4747326	3	4	141	1	0	0	0	0	1	0	0	0	452	603	21	4	2536	4	AKAP3	12	4747326	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4480468	4747326	129104569	356	25631											
GAPDH	2597	broad.mit.edu	37	chr12	6646845	6646845	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggggctctccagaacatcatCcctgcctctactggcgctgc	6	9	10	16	1	3	1	1	0	2	1	5	1	4	1	3	3	4	2	3	3	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:6646845C>A	uc001qop.1	+	8	723	c.621C>A	c.(619-621)ATC>ATA	p.I207I	GAPDH_uc009zep.1_Silent_p.I165I|GAPDH_uc001qoq.1_Silent_p.I132I|GAPDH_uc001qor.1_Silent_p.I166I|GAPDH_uc001qos.1_Silent_p.I207I|GAPDH_uc001qot.1_Silent_p.I207I|GAPDH_uc001qou.1_Silent_p.I166I|GAPDH_uc001qov.1_Silent_p.I165I|GAPDH_uc001qow.1_Silent_p.I160I|GAPDH_uc001qox.1_Silent_p.I33I	NM_002046	NP_002037	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	207					gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding				0					NADH(DB00157)	AGAACATCATCCCTGCCTCTA	0.622											OREG0021628	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	16					0.000308642	0.000326929	1	0	A	6646845	A	A	6646845	2	1	141	1	0	0	0	0	0	0	0	1	6271	845	30	2		2	GAPDH	12	6646845	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1899519	6646845	127205050	357	25632											
C1R	715	broad.mit.edu	37	chr12	7188341	7188341	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgggtggacgctgaccctgCggatggggtgatttcctagc	5	9	16	11	3	0	2	0	2	0	0	1	4	1	4	3	5	2	1	3	5	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:7188341C>A	uc010sfy.1	-	10	1672	c.1613G>T	c.(1612-1614)CGC>CTC	p.R538L		NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	538	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GCTGACCCTGCGGATGGGGTG	0.552													30	98					2.46105e-21	3.50282e-21	1	0	A	7188341	A	A	7188341	3	1	141	1	0	0	0	0	1	0	0	0	1981	768	27	3	508	3	C1R	12	7188341	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	541496	7188341	126663554	358	25633											
BCL2L14	79370	broad.mit.edu	37	chr12	12232294	12232294	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccctagatgatgatgacCtaaacaccatagaattcaaa	16	9	5	11	0	1	5	1	3	0	2	2	5	2	5	4	0	1	0	4	0	6	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:12232294C>T	uc001rac.2	+	2	256	c.55C>T	c.(55-57)CTA>TTA	p.L19L	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_RNA|BCL2L14_uc001rad.2_Silent_p.L19L|BCL2L14_uc001rae.2_Silent_p.L19L	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	19					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		TGATGATGACCTAAACACCAT	0.483													13	96					0	0	0	0	T	12232294	T	T	12232294	2	4	141	1	0	0	0	0	0	0	0	1	1374	680	24	4		4	BCL2L14	12	12232294	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	5043953	12232294	121619601	359	25634											
LST-3TM12	338821	broad.mit.edu	37	chr12	21168707	21168707	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttaattgatggaagcttCgaaataggtagctttttatt	11	17	10	3	1	0	1	0	1	0	0	1	3	0	2	0	3	2	4	0	3	6	10			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:21168707C>A	uc010sin.1	+	1	78	c.78C>A	c.(76-78)TTC>TTA	p.F26L	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Intron	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	26						membrane	transporter activity				0						ATGGAAGCTTCGAAATAGGTA	0.249													10	15					3.86212e-05	4.15093e-05	1	0	A	21168707	A	A	21168707	3	1	141	1	0	0	0	0	1	0	0	0	9116	883	31	3	80	3	LST-3TM12	12	21168707	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	8936413	21168707	112683188	360	25635											
ADAMTS20	80070	broad.mit.edu	37	chr12	43769237	43769237	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctgaaaacagtgtatccAgcagctaagtgtccattgtc	11	12	9	9	0	0	1	0	1	0	0	3	1	2	1	2	0	4	4	2	0	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:43769237A>G	uc010skx.1	-	36	5391	c.5391T>C	c.(5389-5391)GCT>GCC	p.A1797A		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1797	GON.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CAGTGTATCCAGCAGCTAAGT	0.338													15	57					0	0	0	0	G	43769237	G	G	43769237	2	3	141	1	0	0	0	0	0	0	0	1	266	175	7	5		5	ADAMTS20	12	43769237	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	22600530	43769237	90082658	361	25636											
ADAMTS20	80070	broad.mit.edu	37	chr12	43846439	43846439	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgccttttggacatgaatcaGtattacatgatcgaaatttc	12	15	7	7	1	1	2	1	2	0	0	3	4	1	3	1	1	2	1	1	1	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:43846439G>C	uc010skx.1	-	13	1820	c.1820C>G	c.(1819-1821)ACT>AGT	p.T607S		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	607	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding	p.T607T(1)		central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACATGAATCAGTATTACATGA	0.403													3	20					0	0	0	0	C	43846439	C	C	43846439	3	2	141	1	0	0	0	0	1	0	0	0	266	1029	36	4	4019	4	ADAMTS20	12	43846439	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	77202	43846439	90005456	362	25637											
ADAMTS20	80070	broad.mit.edu	37	chr12	43847820	43847820	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatttacaggacgtgtttcCgtttctttgtttacacatag	8	17	7	9	2	1	0	0	0	1	0	2	1	2	1	2	1	2	3	2	1	3	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:43847820C>T	uc010skx.1	-	12	1650	c.1650G>A	c.(1648-1650)ACG>ACA	p.T550T		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	550	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding	p.T550M(1)		central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GACGTGTTTCCGTTTCTTTGT	0.398													4	34					0	0	0	0	T	43847820	T	T	43847820	2	4	141	1	0	0	0	0	0	0	0	1	266	639	23	1		1	ADAMTS20	12	43847820	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1381	43847820	90004075	363	25638											
ADCY6	112	broad.mit.edu	37	chr12	49164737	49164737	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttttccagctgccggaacCgctcctcgctgataatctga	7	12	8	14	3	2	2	0	2	2	0	5	3	4	3	4	1	3	3	4	1	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:49164737C>A	uc001rsh.3	-	19	3728	c.3068G>T	c.(3067-3069)CGG>CTG	p.R1023L	ADCY6_uc001rsj.3_Missense_Mutation_p.R1023L|ADCY6_uc001rsi.3_Missense_Mutation_p.R970L|ADCY6_uc010slw.1_3'UTR	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	1023	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CTGCCGGAACCGCTCCTCGCT	0.577													14	24					1.05317e-09	1.26761e-09	1	0	A	49164737	A	A	49164737	3	1	141	1	0	0	0	0	1	0	0	0	298	652	23	3	450	3	ADCY6	12	49164737	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	5316917	49164737	84687158	364	25639											
RHEBL1	121268	broad.mit.edu	37	chr12	49460759	49460759	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccaactggtacctgccctgCtgtgtccaccagatgtaggt	7	10	10	14	0	0	1	0	0	0	1	1	1	1	1	5	2	4	3	5	2	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:49460759C>T	uc001rtc.1	-	3	391	c.184G>A	c.(184-186)GCA>ACA	p.A62T	RHEBL1_uc001rtd.1_Missense_Mutation_p.A58T|RHEBL1_uc009zlc.1_Intron	NM_144593	NP_653194	Q8TAI7	REBL1_HUMAN	Ras homolog enriched in brain like 1 precursor	62	GTP (By similarity).				positive regulation of NF-kappaB transcription factor activity|small GTPase mediated signal transduction|TOR signaling cascade	cytoplasm|plasma membrane	GTP binding|GTPase activity|protein binding			lung(1)|breast(1)	2						ACCTGCCCTGCTGTGTCCACC	0.453													5	66					0	0	0	0	T	49460759	T	T	49460759	3	4	141	1	0	0	0	0	1	0	0	0	13394	797	28	4	391	4	RHEBL1	12	49460759	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	296022	49460759	84391136	365	25640											
LIMA1	51474	broad.mit.edu	37	chr12	50594642	50594642	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattttatgaattttgattTcgccaccactggctttcagc	8	16	6	11	1	1	2	1	2	0	0	2	2	1	2	3	1	1	1	3	1	2	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:50594642T>C	uc001rwj.3	-	7	1064	c.890A>G	c.(889-891)GAA>GGA	p.E297G	LIMA1_uc001rwg.3_5'UTR|LIMA1_uc001rwh.3_Missense_Mutation_p.E137G|LIMA1_uc001rwi.3_Missense_Mutation_p.E137G|LIMA1_uc001rwk.3_Missense_Mutation_p.E297G|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	297					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						AATTTTGATTTCGCCACCACT	0.388													110	123					0	0	0	0	C	50594642	C	C	50594642	3	2	141	1	0	0	0	0	1	0	0	0	8837	1783	62	5	1412	5	LIMA1	12	50594642	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	1133883	50594642	83257253	366	25641											
SCN8A	6334	broad.mit.edu	37	chr12	52164414	52164414	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcctcatcgtggagcacAactggtttgagaccttcatc	8	12	9	12	1	2	1	2	1	0	1	5	3	3	2	2	2	2	3	2	2	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:52164414A>G	uc001ryw.2	+	19	3770	c.3592A>G	c.(3592-3594)AAC>GAC	p.N1198D	SCN8A_uc010snl.1_Missense_Mutation_p.N1063D	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1198	III.|Helical; Name=S1 of repeat III; (Potential).				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CGTGGAGCACAACTGGTTTGA	0.562													7	44					0	0	0	0	G	52164414	G	G	52164414	3	3	141	1	0	0	0	0	1	0	0	0	13989	130	5	5	3662	5	SCN8A	12	52164414	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	1569772	52164414	81687481	367	25642											
RARG	5916	broad.mit.edu	37	chr12	53621207	53621207	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccccggaagctagggctcagCatctcgaaaggcggagaccc	10	4	13	14	3	2	1	1	0	1	1	3	4	2	2	3	4	2	3	3	4	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:53621207C>G	uc001sce.2	-	3	608	c.123G>C	c.(121-123)ATG>ATC	p.M41I	RARG_uc001scf.2_Missense_Mutation_p.M41I|RARG_uc001scg.2_Intron|RARG_uc010soc.1_Intron	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	41	Modulating.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TAGGGCTCAGCATCTCGAAAG	0.627													62	29					0	0	0	0	G	53621207	G	G	53621207	3	3	141	1	0	0	0	0	1	0	0	0	13119	710	25	4	1428	4	RARG	12	53621207	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1456793	53621207	80230688	368	25643											
ESPL1	9700	broad.mit.edu	37	chr12	53684657	53684657	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccctagagaagtctgtgctGggctgctggaaggggctgct	6	10	16	9	0	1	1	0	0	1	1	2	3	2	2	1	4	3	5	1	4	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:53684657G>T	uc001sck.2	+	25	5488	c.5397G>T	c.(5395-5397)CTG>CTT	p.L1799L	ESPL1_uc001scj.2_Silent_p.L1474L	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1799					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						AGTCTGTGCTGGGCTGCTGGA	0.592													8	11					1.06961e-07	1.22696e-07	1	0	T	53684657	T	T	53684657	2	4	141	1	0	0	0	0	0	0	0	1	5277	1335	47	4		4	ESPL1	12	53684657	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	63450	53684657	80167238	369	25644											
SLC16A7	9194	broad.mit.edu	37	chr12	60168743	60168743	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgattcaagcccaaagaaaAtcaaaacgaagaaatcaact	22	6	5	8	1	3	3	3	1	0	2	3	4	3	3	1	0	3	0	1	0	9	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:60168743A>G	uc001sqs.2	+	5	966	c.667A>G	c.(667-669)ATC>GTC	p.I223V	SLC16A7_uc001sqt.2_Missense_Mutation_p.I223V|SLC16A7_uc001squ.2_Missense_Mutation_p.I223V|SLC16A7_uc009zqi.2_Missense_Mutation_p.I124V|SLC16A7_uc010ssi.1_Missense_Mutation_p.I124V	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	223	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	CCCAAAGAAAATCAAAACGAA	0.363													15	17					0	0	0	0	G	60168743	G	G	60168743	3	3	141	1	0	0	0	0	1	0	0	0	14478	101	4	5	677	5	SLC16A7	12	60168743	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	6484086	60168743	73683152	370	25645											
RASSF3	283349	broad.mit.edu	37	chr12	65088583	65088583	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaactacagaatttcttgcGcatcttggacaaggaagaag	15	9	10	7	1	2	3	0	0	2	3	2	5	2	5	0	2	3	1	0	2	6	4	rs147804503		TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:65088583G>T	uc001ssd.2	+	5	728	c.608G>T	c.(607-609)CGC>CTC	p.R203L	RASSF3_uc009zqn.2_RNA|RASSF3_uc001sse.2_Missense_Mutation_p.R133L	NM_178169	NP_835463	Q86WH2	RASF3_HUMAN	Ras association (RalGDS/AF-6) domain family	203	SARAH.				signal transduction	cytoplasm|microtubule	identical protein binding				0			Lung(2;0.00133)|LUAD - Lung adenocarcinoma(6;0.0665)|LUSC - Lung squamous cell carcinoma(43;0.132)	GBM - Glioblastoma multiforme(28;0.0611)		AATTTCTTGCGCATCTTGGAC	0.473													39	56					2.26627e-22	3.28296e-22	1	0	T	65088583	T	T	65088583	3	4	141	1	0	0	0	0	1	0	0	0	13152	1087	38	3	626	3	RASSF3	12	65088583	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4919840	65088583	68763312	371	25646											
BEST3	144453	broad.mit.edu	37	chr12	70087573	70087573	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgtccttctaagcaggcgcCcgtgctcgtcgcttccgtga	4	10	12	15	6	1	1	0	1	1	0	5	1	3	1	3	1	2	3	3	1	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:70087573C>A	uc001svg.2	-	4	589	c.362G>T	c.(361-363)GGG>GTG	p.G121V	BEST3_uc001svd.1_Missense_Mutation_p.G121V|BEST3_uc001sve.1_RNA|BEST3_uc010stm.1_Missense_Mutation_p.G15V|BEST3_uc001svh.2_5'UTR|BEST3_uc001svi.1_RNA	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	121	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			AAGCAGGCGCCCGTGCTCGTC	0.532													15	30					1.52009e-12	1.95136e-12	1	0	A	70087573	A	A	70087573	3	1	141	1	0	0	0	0	1	0	0	0	1408	623	22	4	1672	4	BEST3	12	70087573	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4998990	70087573	63764322	372	25647											
TRHDE	29953	broad.mit.edu	37	chr12	72936127	72936127	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggccattcagttttccagagGggtttgcaagtaagtaaaat	12	12	11	6	0	1	1	1	0	0	1	2	1	2	1	2	3	1	5	2	3	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:72936127G>A	uc001sxa.2	+	7	1674	c.1644G>A	c.(1642-1644)AGG>AGA	p.R548R		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	548	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTTTCCAGAGGGGTTTGCAAG	0.308													16	20					0	0	0	0	A	72936127	A	A	72936127	2	1	141	1	0	0	0	0	0	0	0	1	16546	1223	43	4		4	TRHDE	12	72936127	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2848554	72936127	60915768	373	25648											
NAV3	89795	broad.mit.edu	37	chr12	78400833	78400833	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctccaaaattgcaagcttGatccctaagggcagcaagac	14	7	8	12	0	0	2	0	1	0	1	2	2	2	2	3	1	3	4	3	1	5	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:78400833G>A	uc001syp.2	+	8	1688	c.1515G>A	c.(1513-1515)TTG>TTA	p.L505L	NAV3_uc001syo.2_Silent_p.L505L	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	505						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TTGCAAGCTTGATCCCTAAGG	0.428										HNSCC(70;0.22)			35	29					0	0	0	0	A	78400833	A	A	78400833	2	1	141	1	0	0	0	0	0	0	0	1	10238	1281	45	2		2	NAV3	12	78400833	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	5464706	78400833	55451062	374	25649											
NAV3	89795	broad.mit.edu	37	chr12	78553062	78553062	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaactatgacagcggaacAaaaggtatgttcagaaattg	16	10	9	6	1	2	2	1	1	1	1	2	3	2	3	0	2	3	2	0	2	7	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:78553062A>C	uc001syp.2	+	23	5038	c.4865A>C	c.(4864-4866)CAA>CCA	p.Q1622P	NAV3_uc001syo.2_Missense_Mutation_p.Q1622P|NAV3_uc010sub.1_Missense_Mutation_p.Q1108P|NAV3_uc009zsf.2_Missense_Mutation_p.Q453P	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1622	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACAGCGGAACAAAAGGTATGT	0.383										HNSCC(70;0.22)			13	42					0	0	0	0	C	78553062	C	C	78553062	3	2	141	1	0	0	0	0	1	0	0	0	10238	130	5	5	4955	5	NAV3	12	78553062	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	152229	78553062	55298833	375	25650											
PPFIA2	8499	broad.mit.edu	37	chr12	82147793	82147793	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtctctggagtgagtctcGgtcatagatgacatcctgaa	9	12	11	9	1	3	4	1	3	2	1	6	5	4	5	1	2	0	0	1	2	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:82147793G>T	uc001szo.1	-	3	369	c.208C>A	c.(208-210)CGA>AGA	p.R70R	PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(3)|lung(2)|pancreas(1)	6						AGTGAGTCTCGGTCATAGATG	0.468													6	20					2.0095e-06	2.2488e-06	1	0	T	82147793	T	T	82147793	2	4	141	1	0	0	0	0	0	0	0	1	12365	1124	39	3		3	PPFIA2	12	82147793	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3594731	82147793	51704102	376	25651											
ALX1	8092	broad.mit.edu	37	chr12	85677506	85677506	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	taaatgtgatagcaatgtatCcagcagtaagaaacggaggc	16	8	11	6	1	0	2	0	1	0	1	1	3	1	3	1	2	3	4	1	2	7	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:85677506C>T	uc001tae.3	+	2	387	c.383C>T	c.(382-384)TCC>TTC	p.S128F		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	128					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		AGCAATGTATCCAGCAGTAAG	0.478													41	38					0	0	0	0	T	85677506	T	T	85677506	3	4	141	1	0	0	0	0	1	0	0	0	556	855	30	2	389	2	ALX1	12	85677506	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3529713	85677506	48174389	377	25652											
C12orf50	160419	broad.mit.edu	37	chr12	88381702	88381702	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgcgttgtaggtactagtcGggtagttagggaatgctttg	8	14	15	4	2	0	0	0	0	0	0	1	1	0	1	0	3	3	6	0	3	6	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:88381702G>A	uc001tam.1	-	9	910	c.742C>T	c.(742-744)CGA>TGA	p.R248*	C12orf50_uc001tan.2_Intron	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	248										skin(2)|ovary(1)	3						GGTACTAGTCGGGTAGTTAGG	0.343													23	31					0	0	0	0	A	88381702	A	A	88381702	4	1	141	1	0	0	0	0	0	1	0	0	1701	1124	39	1	522	1	C12orf50	12	88381702	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2704196	88381702	45470193	378	25653											
STAB2	55576	broad.mit.edu	37	chr12	104152959	104152959	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctcgccaatgtcagcatgTttttctacaatgaccttgtc	9	14	6	12	1	2	1	1	1	1	0	4	1	2	1	3	0	2	2	3	0	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:104152959T>C	uc001tjw.2	+	65	7342	c.7156T>C	c.(7156-7158)TTT>CTT	p.F2386L	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2386	Extracellular (Potential).|FAS1 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TGTCAGCATGTTTTTCTACAA	0.507													58	51					0	0	0	0	C	104152959	C	C	104152959	3	2	141	1	0	0	0	0	1	0	0	0	15304	1725	60	5	7414	5	STAB2	12	104152959	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	15771257	104152959	29698936	379	25654											
ACACB	32	broad.mit.edu	37	chr12	109684049	109684049	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggaaggacgggatgtgatCgtcatcggcaatgacatcac	11	7	13	10	4	2	2	2	2	0	0	4	5	2	5	1	4	0	1	1	4	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:109684049C>A	uc001tob.2	+	39	5486	c.5367C>A	c.(5365-5367)ATC>ATA	p.I1789I	ACACB_uc001toc.2_Silent_p.I1789I|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.I455I	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1789					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGGATGTGATCGTCATCGGCA	0.552													39	33					1.57019e-19	2.20912e-19	1	0	A	109684049	A	A	109684049	2	1	141	1	0	0	0	0	0	0	0	1	107	874	31	3		3	ACACB	12	109684049	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	5531090	109684049	24167846	380	25655											
ATXN2	6311	broad.mit.edu	37	chr12	111923529	111923529	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgacttacttgcacgcctggGctcactgggactggatacat	8	11	11	11	1	1	1	1	1	0	0	1	3	1	3	1	3	3	2	1	3	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:111923529G>A	uc001tsj.2	-	17	3087	c.2925C>T	c.(2923-2925)AGC>AGT	p.S975S	ATXN2_uc001tsh.2_Silent_p.S710S|ATXN2_uc001tsi.2_Silent_p.S686S|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Silent_p.S161S	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	975	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						GCACGCCTGGGCTCACTGGGA	0.453													16	56					0	0	0	0	A	111923529	A	A	111923529	2	1	141	1	0	0	0	0	0	0	0	1	1213	1194	42	4		4	ATXN2	12	111923529	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2239480	111923529	21928366	381	25656											
NOS1	4842	broad.mit.edu	37	chr12	117685212	117685212	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcccacagagctcatcccCttccctcatcttcaggatcc	7	10	5	19	0	4	1	3	0	1	1	7	2	7	2	5	1	2	1	5	1	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:117685212C>T	uc001twm.1	-	18	3450	c.2764G>A	c.(2764-2766)GGG>AGG	p.G922R		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	922	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGCTCATCCCCTTCCCTCATC	0.552													54	61					0	0	0	0	T	117685212	T	T	117685212	3	4	141	1	0	0	0	0	1	0	0	0	10595	681	24	4	1588	4	NOS1	12	117685212	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	5761683	117685212	16166683	382	25657											
CIT	11113	broad.mit.edu	37	chr12	120173008	120173008	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctcgttccgtgatctccCggcggagatggtccacttca	5	12	10	14	4	3	2	1	1	2	1	8	3	5	2	3	3	0	1	3	3	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:120173008C>A	uc001txi.1	-	24	3040	c.2987G>T	c.(2986-2988)CGG>CTG	p.R996L	CIT_uc001txh.1_Missense_Mutation_p.R530L|CIT_uc001txj.1_Missense_Mutation_p.R1038L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	996	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CGTGATCTCCCGGCGGAGATG	0.498													31	88					4.3181e-19	6.01743e-19	1	0	A	120173008	A	A	120173008	3	1	141	1	0	0	0	0	1	0	0	0	3453	652	23	3	3192	3	CIT	12	120173008	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2487796	120173008	13678887	383	25658											
PXN	5829	broad.mit.edu	37	chr12	120652757	120652757	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctggcagtgggtgcaGacgaagtgctcggggtgcca	6	8	16	11	2	0	1	0	0	0	1	3	2	2	1	3	4	3	3	3	4	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:120652757G>T	uc001txt.2	-	9	1280	c.1149C>A	c.(1147-1149)GTC>GTA	p.V383V	PXN_uc001txu.2_Silent_p.V195V|PXN_uc001txv.2_Silent_p.V264V|PXN_uc001txx.2_Silent_p.V216V|PXN_uc001txy.2_Silent_p.V349V|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	383	LIM zinc-binding 1.				cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGTGGGTGCAGACGAAGTGCT	0.632													4	23					0.00024832	0.000264562	1	0	T	120652757	T	T	120652757	2	4	141	1	0	0	0	0	0	0	0	1	12917	929	33	2		2	PXN	12	120652757	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	479749	120652757	13199138	384	25659											
PITPNM2	57605	broad.mit.edu	37	chr12	123485364	123485364	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccacactggaggccaccctGaactcaggggcaccctggcg	8	5	12	16	1	1	1	1	1	0	0	2	2	2	2	4	5	1	1	4	5	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:123485364G>A	uc001uej.1	-	9	1324	c.1185C>T	c.(1183-1185)TTC>TTT	p.F395F	PITPNM2_uc001uek.1_Silent_p.F395F|PITPNM2_uc009zxu.1_Silent_p.F395F	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	395					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		AGGCCACCCTGAACTCAGGGG	0.652													4	26					0	0	0	0	A	123485364	A	A	123485364	2	1	141	1	0	0	0	0	0	0	0	1	12006	1281	45	2		2	PITPNM2	12	123485364	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2832607	123485364	10366531	385	25660											
GTF2H3	2967	broad.mit.edu	37	chr12	124144433	124144433	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctgcttgcttctgtcatcGaaatctcattgaaattggtt	8	16	9	8	1	3	1	2	1	2	0	5	2	3	1	0	2	2	4	0	2	2	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:124144433G>A	uc001ufo.1	+	11	802	c.776G>A	c.(775-777)CGA>CAA	p.R259Q	GTF2H3_uc010tau.1_Missense_Mutation_p.R218Q	NM_001516	NP_001507	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3,	259					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		TTCTGTCATCGAAATCTCATT	0.413								NER					16	68					0	0	0	0	A	124144433	A	A	124144433	3	1	141	1	0	0	0	0	1	0	0	0	6903	1058	37	1	818	1	GTF2H3	12	124144433	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	659069	124144433	9707462	386	25661											
TCTN2	79867	broad.mit.edu	37	chr12	124191294	124191294	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctcctcagtgaactggcaGtaccagtgtgggcttacctg	7	12	11	11	0	2	1	1	1	1	0	3	1	2	1	3	2	3	3	3	2	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:124191294G>T	uc001ufp.2	+	16	1919	c.1791G>T	c.(1789-1791)CAG>CAT	p.Q597H	TCTN2_uc009zya.2_Missense_Mutation_p.Q596H	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	597	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TGAACTGGCAGTACCAGTGTG	0.502													39	61					2.26627e-22	3.28296e-22	1	0	T	124191294	T	T	124191294	3	4	141	1	0	0	0	0	1	0	0	0	15789	1020	36	4	1853	4	TCTN2	12	124191294	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	46861	124191294	9660601	387	25662											
RIMBP2	23504	broad.mit.edu	37	chr12	130926460	130926460	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctccagcgggagctgccaCggcatctggtggggtttggc	4	9	17	11	2	1	0	0	0	1	0	2	1	2	1	2	6	4	4	2	6	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:130926460C>A	uc001uil.2	-	8	1550	c.1386G>T	c.(1384-1386)CCG>CCT	p.P462P	RIMBP2_uc001uim.2_Silent_p.P370P|RIMBP2_uc001uin.1_Silent_p.P121P	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	462	Fibronectin type-III 2.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGAGCTGCCACGGCATCTGGT	0.587													22	32					2.39556e-15	3.18684e-15	1	0	A	130926460	A	A	130926460	2	1	141	1	0	0	0	0	0	0	0	1	13428	523	19	3		3	RIMBP2	12	130926460	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	6735166	130926460	2925435	388	25663											
EP400	57634	broad.mit.edu	37	chr12	132510276	132510276	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgcagaccgtgtctcaggcGggcgctgtgcacggcgccct	5	7	15	14	5	1	1	1	0	1	1	2	1	1	1	2	3	2	3	2	3	0	0	rs79827647	by1000genomes	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:132510276G>T	uc001ujn.2	+	24	4976	c.4941G>T	c.(4939-4941)GCG>GCT	p.A1647A	EP400_uc001ujl.2_Silent_p.A1646A|EP400_uc001ujm.2_Silent_p.A1566A	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1683					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TGTCTCAGGCGGGCGCTGTGC	0.692													5	24					1.23904e-05	1.35555e-05	1	0	T	132510276	T	T	132510276	2	4	141	1	0	0	0	0	0	0	0	1	5173	1103	39	3		3	EP400	12	132510276	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1583816	132510276	1341619	389	25664											
CHFR	55743	broad.mit.edu	37	chr12	133433063	133433063	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatgatttacctaatgtctGaggactcactgtcaacgtct	10	13	8	10	1	4	2	2	2	2	0	4	3	4	3	1	1	2	1	1	1	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:133433063G>C	uc001ulf.2	-	10	1340	c.1256C>G	c.(1255-1257)TCA>TGA	p.S419*	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Nonsense_Mutation_p.S407*|CHFR_uc010tbs.1_Nonsense_Mutation_p.S419*|CHFR_uc001uld.2_Nonsense_Mutation_p.S378*|CHFR_uc010tbt.1_Nonsense_Mutation_p.S327*	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	419					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		CCTAATGTCTGAGGACTCACT	0.537													31	108					0	0	0	0	C	133433063	C	C	133433063	4	2	141	1	0	0	0	0	0	1	0	0	3352	1294	45	2	774	2	CHFR	12	133433063	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	922787	133433063	418832	390	25665											
FREM2	341640	broad.mit.edu	37	chr13	39262131	39262131	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccgagacagaggagtgccGcgtgggcatcctgtccggct	6	6	16	13	4	0	2	0	0	0	2	2	4	2	3	4	3	1	2	4	3	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:39262131G>T	uc001uwv.2	+	1	959	c.650G>T	c.(649-651)CGC>CTC	p.R217L		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	217	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GAGGAGTGCCGCGTGGGCATC	0.682													34	11					9.17885e-22	1.31665e-21	1	0	T	39262131	T	T	39262131	3	4	141	1	0	0	0	0	1	0	0	0	6079	1087	38	3	652	3	FREM2	13	39262131	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08		39262131	75907747	391	25666											
RB1	5925	broad.mit.edu	37	chr13	48941688	48941688	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taaaaataaagatctagatgCaagattatttttggatcatg	17	14	7	3	0	2	3	1	0	1	3	2	4	2	4	0	1	1	1	0	1	8	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:48941688C>T	uc001vcb.2	+	10	1164	c.998C>T	c.(997-999)GCA>GTA	p.A333V	RB1_uc010act.1_Missense_Mutation_p.A34V	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	333					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GATCTAGATGCAAGATTATTT	0.284		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			48	29					0	0	0	0	T	48941688	T	T	48941688	3	4	141	1	0	0	0	0	1	0	0	0	13163	710	25	4	1036	4	RB1	13	48941688	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	9679557	48941688	66228190	392	25667											
PCDH17	27253	broad.mit.edu	37	chr13	58298958	58298958	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttttgtacatttggaaaaGacaagcgagagcacactatt	14	12	8	7	1	0	2	0	0	0	2	0	4	0	3	0	1	3	2	0	1	5	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:58298958G>C	uc001vhq.1	+	4	3902	c.3010G>C	c.(3010-3012)GAC>CAC	p.D1004H	PCDH17_uc010aec.1_Missense_Mutation_p.D1003H|PCDH17_uc001vhr.1_Missense_Mutation_p.D93H	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1004	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATTTGGAAAAGACAAGCGAGA	0.433													55	23					0	0	0	0	C	58298958	C	C	58298958	3	2	141	1	0	0	0	0	1	0	0	0	11566	942	33	2	3024	2	PCDH17	13	58298958	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	9357270	58298958	56870920	393	25668											
PCDH20	64881	broad.mit.edu	37	chr13	61985813	61985813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtctgcagcaatgcctcttCcaaagtaatgttgccagttt	9	14	8	10	0	2	0	0	0	2	0	3	0	3	0	3	0	4	5	3	0	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:61985813C>T	uc001vid.3	-	2	2783	c.2419G>A	c.(2419-2421)GAA>AAA	p.E807K	PCDH20_uc010thj.1_Missense_Mutation_p.E807K	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	780	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		AATGCCTCTTCCAAAGTAATG	0.488													81	30					0	0	0	0	T	61985813	T	T	61985813	3	4	141	1	0	0	0	0	1	0	0	0	11569	864	30	2	440	2	PCDH20	13	61985813	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3686855	61985813	53184065	394	25669											
FARP1	10160	broad.mit.edu	37	chr13	99092244	99092244	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgaagacgagtggggggtGccccactgcctgaccctccg	7	5	15	14	3	0	2	0	1	0	1	1	4	1	2	5	3	3	0	5	3	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:99092244G>T	uc001vnj.2	+	22	2799	c.2463G>T	c.(2461-2463)GTG>GTT	p.V821V	FARP1_uc001vnh.2_Silent_p.V852V	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	821	PH 1.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGTGGGGGGTGCCCCACTGCC	0.617													157	65					1.46131e-73	2.32857e-73	1	0	T	99092244	T	T	99092244	2	4	141	1	0	0	0	0	0	0	0	1	5708	1306	46	4		4	FARP1	13	99092244	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	37106431	99092244	16077634	395	25670											
DOCK9	23348	broad.mit.edu	37	chr13	99481561	99481561	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggctggcagggctactacCtctgagagatcgccattttt	7	11	12	11	2	1	2	0	1	1	1	2	3	1	2	2	3	2	3	2	3	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:99481561C>G	uc001vnt.2	-	43	4954	c.4899G>C	c.(4897-4899)GAG>GAC	p.E1633D	DOCK9_uc001vnw.2_Missense_Mutation_p.E1632D|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.E1633D|DOCK9_uc001vnq.2_Missense_Mutation_p.E205D|DOCK9_uc001vnr.2_Missense_Mutation_p.E276D|DOCK9_uc010tin.1_Missense_Mutation_p.E276D|DOCK9_uc001vns.2_Missense_Mutation_p.E205D|DOCK9_uc010tio.1_Missense_Mutation_p.E325D|DOCK9_uc010tip.1_Missense_Mutation_p.E343D|DOCK9_uc001vnu.1_Missense_Mutation_p.E205D|DOCK9_uc010tiq.1_Missense_Mutation_p.E611D	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1633	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GGGCTACTACCTCTGAGAGAT	0.488													4	2					0	0	0	0	G	99481561	G	G	99481561	3	3	141	1	0	0	0	0	1	0	0	0	4716	695	24	4	1362	4	DOCK9	13	99481561	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	389317	99481561	15688317	396	25671											
MYO16	23026	broad.mit.edu	37	chr13	109793638	109793638	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccaggcctctcagcagccCcctggacgagctcgccagcc	6	5	10	20	2	1	0	1	0	1	0	4	2	2	1	6	2	4	2	6	2	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:109793638C>A	uc001vqt.1	+	32	5138	c.5012C>A	c.(5011-5013)CCC>CAC	p.P1671H	MYO16_uc010agk.1_Missense_Mutation_p.P1693H	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1671	Pro-rich.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CTCAGCAGCCCCCTGGACGAG	0.672													6	4					8.12818e-05	8.69775e-05	1	0	A	109793638	A	A	109793638	3	1	141	1	0	0	0	0	1	0	0	0	10117	623	22	4	5134	4	MYO16	13	109793638	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	10312077	109793638	5376240	397	25672											
MCF2L	23263	broad.mit.edu	37	chr13	113729415	113729415	+	Frame_Shift_Del	DEL	G	-	-																															cccaaagtgccaggagctccGgcacctctgtgaccagttct																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:113729415delG	uc001vsu.2	+	11	1413	c.1391delG	c.(1390-1392)CGGfs	p.R464fs	MCF2L_uc001vsq.2_Frame_Shift_Del_p.R464fs|MCF2L_uc010tjr.1_Frame_Shift_Del_p.R407fs|MCF2L_uc001vsr.2_Frame_Shift_Del_p.R411fs|MCF2L_uc001vss.3_Frame_Shift_Del_p.R405fs|MCF2L_uc010tjs.1_Frame_Shift_Del_p.R405fs|MCF2L_uc001vst.1_Frame_Shift_Del_p.R369fs	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	437	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CAGGAGCTCCGGCACCTCTGT	0.667													---	---	---								-	113729415	-	-	113729415	7	5	141	1	0	1	0	1	0	0	0	0	9432	1116	39	0	1528	0	MCF2L	13	113729415	Frame_Shift_Del	DEL	G	TCGA-CR-7370-01A-11D-2129-08	3935777	113729415	1440463	398	25673											
REM2	161253	broad.mit.edu	37	chr14	23354038	23354038	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccaggctgtagatgaacttGactggccacctcaggcctca	9	8	10	14	0	2	3	2	2	0	1	2	3	2	3	4	3	1	2	4	3	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:23354038G>C	uc001whf.1	+	2	324	c.259G>C	c.(259-261)GAC>CAC	p.D87H	REM2_uc010tnd.1_Missense_Mutation_p.D79H	NM_173527	NP_775798	Q8IYK8	REM2_HUMAN	rad and gem related GTP binding protein 2	87					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)		AGATGAACTTGACTGGCCACC	0.622													7	81					0	0	0	0	C	23354038	C	C	23354038	3	2	141	1	0	0	0	0	1	0	0	0	13288	1290	45	2	265	2	REM2	14	23354038	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08		23354038	83995502	399	25674											
REM2	161253	broad.mit.edu	37	chr14	23355356	23355356	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agaccctacttcggctccggGctgggaggccgcaccacgac	7	5	13	16	4	0	1	0	0	0	1	2	3	1	2	4	4	1	3	4	4	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:23355356G>A	uc001whf.1	+	4	708	c.643G>A	c.(643-645)GCT>ACT	p.A215T	REM2_uc010tnd.1_Missense_Mutation_p.G182D	NM_173527	NP_775798	Q8IYK8	REM2_HUMAN	rad and gem related GTP binding protein 2	215					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)		TCGGCTCCGGGCTGGGAGGCC	0.597													7	61					0	0	0	0	A	23355356	A	A	23355356	3	1	141	1	0	0	0	0	1	0	0	0	13288	1203	42	4	657	4	REM2	14	23355356	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1318	23355356	83994184	400	25675											
EFS	10278	broad.mit.edu	37	chr14	23826490	23826491	+	Frame_Shift_Del	DEL	TC	-	-																															gcagggcctgccctgccagtTctgttacacactgcaccatc																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:23826490_23826491delTC	uc001wjo.2	-	6	2238_2239	c.1630_1631delGA	c.(1630-1632)GAAfs	p.E544fs	EFS_uc001wjp.2_Frame_Shift_Del_p.E451fs|EFS_uc010tnm.1_Frame_Shift_Del_p.E375fs	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	544					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		CCCTGCCAGTTCTGTTACACAC	0.619													---	---	---								-	23826491	-	-	23826490	7	5	141	1	0	1	0	1	0	0	0	0	4981	1783	62	0	58	0	EFS	14	23826490	Frame_Shift_Del	DEL	TC	TCGA-CR-7370-01A-11D-2129-08	471134	23826490	83523050	401	25676											
CTSG	1511	broad.mit.edu	37	chr14	25043923	25043923	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggatggtccgctgattataTtgagggtggcggatggctct	6	13	16	6	2	1	2	0	2	1	0	2	4	2	4	1	6	0	2	1	6	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:25043923T>C	uc001wpq.2	-	3	334	c.297A>G	c.(295-297)CAA>CAG	p.Q99Q		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	99	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		GCTGATTATATTGAGGGTGGC	0.537													104	28					0	0	0	0	C	25043923	C	C	25043923	2	2	141	1	0	0	0	0	0	0	0	1	4052	1490	52	5		5	CTSG	14	25043923	Silent	SNP	T	TCGA-CR-7370-01A-11D-2129-08	1217433	25043923	82305617	402	25677											
STRN3	29966	broad.mit.edu	37	chr14	31405784	31405784	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcttcatcactgtcatCggcattttctaagaaattga	11	15	5	10	1	6	2	4	1	2	1	7	2	6	2	0	1	0	1	0	1	2	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:31405784C>A	uc001wqu.2	-	6	979	c.763G>T	c.(763-765)GAT>TAT	p.D255Y	STRN3_uc001wqv.2_Missense_Mutation_p.D255Y|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	255					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TCACTGTCATCGGCATTTTCT	0.363													58	17					2.37032e-18	3.25365e-18	1	0	A	31405784	A	A	31405784	3	1	141	1	0	0	0	0	1	0	0	0	15396	884	31	3	1682	3	STRN3	14	31405784	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	6361861	31405784	75943756	403	25678											
STRN3	29966	broad.mit.edu	37	chr14	31405799	31405799	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcatcggcattttctaagaAattgaacgtctcaagaacat	14	12	7	8	2	3	3	2	1	2	2	5	3	3	3	0	1	2	1	0	1	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:31405799A>C	uc001wqu.2	-	6	964	c.748T>G	c.(748-750)TTC>GTC	p.F250V	STRN3_uc001wqv.2_Missense_Mutation_p.F250V|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	250					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TTTTCTAAGAAATTGAACGTC	0.383													51	17					0	0	0	0	C	31405799	C	C	31405799	3	2	141	1	0	0	0	0	1	0	0	0	15396	14	1	5	1697	5	STRN3	14	31405799	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	15	31405799	75943741	404	25679											
CDKL1	8814	broad.mit.edu	37	chr14	50857053	50857053	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacactgtcctgtccttgacCtccaactccgctaggagcat	8	10	8	15	1	0	1	0	1	0	0	4	3	4	2	5	1	2	2	5	1	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:50857053C>T	uc010anu.1	-	6	856	c.856G>A	c.(856-858)GGT>AGT	p.G286S	CDKL1_uc001wxz.2_Intron	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	Error:Variant_position_missing_in_Q00532_after_alignment						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					TGTCCTTGACCTCCAACTCCG	0.478													21	34					0	0	0	0	T	50857053	T	T	50857053	3	4	141	1	0	0	0	0	1	0	0	0	3168	696	24	4		4	CDKL1	14	50857053	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	19451254	50857053	56492487	405	25680											
FBXO34	55030	broad.mit.edu	37	chr14	55818402	55818402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgaattgcccacagatgctGttgattgtatgagcagagag	11	11	12	7	0	0	5	0	3	0	2	0	6	0	5	1	0	3	4	1	0	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:55818402G>A	uc001xbu.2	+	2	1539	c.1294G>A	c.(1294-1296)GTT>ATT	p.V432I	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.V432I	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	432										ovary(2)|lung(2)|skin(1)	5						CACAGATGCTGTTGATTGTAT	0.418													16	282					0	0	0	0	A	55818402	A	A	55818402	3	1	141	1	0	0	0	0	1	0	0	0	5776	1377	48	4	1296	4	FBXO34	14	55818402	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4961349	55818402	51531138	406	25681											
DACT1	51339	broad.mit.edu	37	chr14	59112862	59112862	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaagttgtacagcccctgaaAaagatgtcacagaaaaacag	19	6	8	8	0	1	3	1	1	0	2	1	3	1	3	2	0	3	2	2	0	6	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:59112862A>G	uc001xdw.2	+	4	1685	c.1521A>G	c.(1519-1521)AAA>AAG	p.K507K	DACT1_uc010trv.1_Silent_p.K226K|DACT1_uc001xdx.2_Silent_p.K470K|DACT1_uc010trw.1_Silent_p.K226K	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	507					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						AGCCCCTGAAAAAGATGTCAC	0.592													159	29					0	0	0	0	G	59112862	G	G	59112862	2	3	141	1	0	0	0	0	0	0	0	1	4239	11	1	5		5	DACT1	14	59112862	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	3294460	59112862	48236678	407	25682											
C14orf149	112849	broad.mit.edu	37	chr14	59950740	59950741	+	Missense_Mutation	DNP	CC	AA	AA																															gccgcacatggagctgtagcCctcgttgtgcaggaacagga																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:59950740_59950741CC>AA	uc001xee.1	-	1	333_334	c.294_295GG>TT	c.(292-297)GAGGGC>GATTGC	p.98_99EG>DC	C14orf149_uc010trx.1_Missense_Mutation_p.98_99EG>DC|JKAMP_uc001xef.3_5'Flank|JKAMP_uc001xeh.3_5'Flank|JKAMP_uc001xeg.3_5'Flank|JKAMP_uc010try.1_5'Flank|JKAMP_uc001xei.3_5'Flank	NM_144581	NP_653182	Q96EM0	PRCM_HUMAN	proline racemase-like	98_99							proline racemase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.14)	L-Proline(DB00172)	GAGCTGTAGCCCTCGTTGTGCA	0.708											OREG0022712	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	21					0	0	0	0	AA	59950741	AA	AA	59950740	3	1	141	1	0	0	0	0	1	0	0	0	1758	623	22	4	789	4	C14orf149	14	59950740	Missense_Mutation	DNP	CC	TCGA-CR-7370-01A-11D-2129-08	837878	59950740	47398800	408	25683											
PPM1A	5494	broad.mit.edu	37	chr14	60756619	60756619	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcctcccaccagggggtGaattggcaagcaagtaagtt	11	7	12	11	0	0	1	0	1	0	0	1	1	1	1	4	3	2	4	4	3	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:60756619G>T	uc010apn.2	+	5	1450	c.1048G>T	c.(1048-1050)GAA>TAA	p.E350*	PPM1A_uc001xew.3_Nonsense_Mutation_p.E423*|PPM1A_uc001xey.3_Nonsense_Mutation_p.E350*	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	350					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		ACCAGGGGGTGAATTGGCAAG	0.438													28	37					8.58068e-18	1.16908e-17	1	0	T	60756619	T	T	60756619	4	4	141	1	0	0	0	0	0	1	0	0	12395	1291	45	2	1304	2	PPM1A	14	60756619	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	805879	60756619	46592921	409	25684											
RHOJ	57381	broad.mit.edu	37	chr14	63671525	63671525	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggctttctgccgcttcatGtgctttggaaaaagcaggag	8	12	12	9	1	2	0	1	0	1	0	2	2	2	2	1	3	3	4	1	3	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:63671525G>A	uc001xgb.1	+	1	381	c.-62G>A	c.(-64--60)ATGTG>ATATG			NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	ras homolog gene family, member J precursor						actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		GCCGCTTCATGTGCTTTGGAA	0.527													3	4					0	0	0	0	A	63671525	A	A	63671525	1	1	141	1	0	0	0	0	0	0	0	0	13406	1392	48	4		4	RHOJ	14	63671525	Translation_Start_Site	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2914906	63671525	43678015	410	25685											
SPTB	6710	broad.mit.edu	37	chr14	65268548	65268548	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttggtgacattaacatgagGgtagctgcatccaagagaaa	14	9	12	6	0	0	3	0	2	0	1	1	4	1	3	1	2	3	4	1	2	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:65268548G>A	uc001xht.2	-	5	625	c.571C>T	c.(571-573)CCT>TCT	p.P191S	SPTB_uc001xhr.2_Missense_Mutation_p.P191S|SPTB_uc001xhs.2_Missense_Mutation_p.P191S|SPTB_uc001xhu.2_Missense_Mutation_p.P191S	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	191	Actin-binding.|CH 2.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TTAACATGAGGGTAGCTGCAT	0.463											OREG0022735	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	129	17					0	0	0	0	A	65268548	A	A	65268548	3	1	141	1	0	0	0	0	1	0	0	0	15184	1232	43	4	6608	4	SPTB	14	65268548	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1597023	65268548	42080992	411	25686											
C14orf115	55237	broad.mit.edu	37	chr14	74825284	74825284	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcttcttcagaagatgtaGagggagggccttccagagag	10	8	16	7	0	2	4	1	0	1	4	3	6	3	5	2	3	0	2	2	3	2	4	rs45447993	by1000genomes	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:74825284G>A	uc001xpw.3	+	2	1989	c.1798G>A	c.(1798-1800)GAG>AAG	p.E600K		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	600					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		AGAAGATGTAGAGGGAGGGCC	0.662													52	20					0	0	0	0	A	74825284	A	A	74825284	3	1	141	1	0	0	0	0	1	0	0	0	1746	943	33	2	1800	2	C14orf115	14	74825284	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	9556736	74825284	32524256	412	25687											
ISM2	145501	broad.mit.edu	37	chr14	77948965	77948965	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgggctcagccaacaggtCtatcgacacctcggcctggg	7	7	13	14	2	2	0	1	0	1	0	4	1	2	0	3	4	2	2	3	4	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:77948965C>A	uc001xtz.2	-	4	747	c.673G>T	c.(673-675)GAC>TAC	p.D225Y	ISM2_uc001xua.2_Intron|ISM2_uc001xty.2_Missense_Mutation_p.D137Y|ISM2_uc010tvl.1_Missense_Mutation_p.D144Y	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	225						extracellular region				skin(1)	1						GCCAACAGGTCTATCGACACC	0.612													107	151					1.07149e-41	1.67107e-41	1	0	A	77948965	A	A	77948965	3	1	141	1	0	0	0	0	1	0	0	0	7900	913	32	2	1058	2	ISM2	14	77948965	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3123681	77948965	29400575	413	25688											
SEL1L	6400	broad.mit.edu	37	chr14	81953772	81953772	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatcgcatcacgccggtgcCactggcatgcatctgagcta	8	9	11	13	3	2	2	1	2	1	0	3	2	2	2	2	2	3	4	2	2	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:81953772C>T	uc010tvv.1	-	16	1711	c.1594G>A	c.(1594-1596)GGC>AGC	p.G532S		NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	532	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Sel1-like 9.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		ACGCCGGTGCCACTGGCATGC	0.478													60	17					0	0	0	0	T	81953772	T	T	81953772	3	4	141	1	0	0	0	0	1	0	0	0	14075	594	21	4	814	4	SEL1L	14	81953772	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4004807	81953772	25395768	414	25689											
FLRT2	23768	broad.mit.edu	37	chr14	86088031	86088031	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgaagcttgacctcagtgcCtcttgggatcccggagggcg	6	8	15	12	3	2	1	1	1	1	0	3	4	3	3	3	3	2	1	3	3	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:86088031C>G	uc001xvr.2	+	2	940	c.173C>G	c.(172-174)CCT>CGT	p.P58R	FLRT2_uc010atd.2_Missense_Mutation_p.P58R	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	58	Extracellular (Potential).|LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		ACCTCAGTGCCTCTTGGGATC	0.522													157	48					0	0	0	0	G	86088031	G	G	86088031	3	3	141	1	0	0	0	0	1	0	0	0	5971	681	24	4	175	4	FLRT2	14	86088031	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4134259	86088031	21261509	415	25690											
CYP46A1	10858	broad.mit.edu	37	chr14	100157458	100157458	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcttttggaaaaaggatGaggttggtggccgtgtgctc	7	12	15	7	1	0	1	0	1	0	0	1	3	0	3	2	5	2	3	2	5	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:100157458G>T	uc001ygo.2	+	2	160	c.160G>T	c.(160-162)GAG>TAG	p.E54*	CYP46A1_uc001ygn.1_Missense_Mutation_p.M1I	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	54					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GAAAAAGGATGAGGTTGGTGG	0.502													76	115					3.64303e-30	5.52865e-30	1	0	T	100157458	T	T	100157458	4	4	141	1	0	0	0	0	0	1	0	0	4199	1291	45	2	166	2	CYP46A1	14	100157458	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	14069427	100157458	7192082	416	25691											
DEGS2	123099	broad.mit.edu	37	chr14	100615483	100615483	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcaggcccaggcccaggaagGagctggccagcaggtagacc	10	2	16	13	0	0	1	0	0	0	1	0	3	0	3	4	6	2	4	4	6	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:100615483G>C	uc001ygx.2	-	2	735	c.647C>G	c.(646-648)TCC>TGC	p.S216C		NM_206918	NP_996801	Q6QHC5	DEGS2_HUMAN	degenerative spermatocyte homolog 2, lipid	216	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity				0		Melanoma(154;0.212)				GCCCAGGAAGGAGCTGGCCAG	0.647													83	17					0	0	0	0	C	100615483	C	C	100615483	3	2	141	1	0	0	0	0	1	0	0	0	4445	1174	41	2	332	2	DEGS2	14	100615483	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	458025	100615483	6734057	417	25692											
AHNAK2	113146	broad.mit.edu	37	chr14	105419983	105419983	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttctgtggctttttctCtgcctgtctttgtgtgcttg	0	22	10	9	0	4	0	0	0	4	0	5	0	4	0	1	1	2	2	1	1	0	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:105419983C>A	uc010axc.1	-	7	1925	c.1805G>T	c.(1804-1806)AGA>ATA	p.R602I	AHNAK2_uc001ypx.2_Missense_Mutation_p.R502I	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	602						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGCTTTTTCTCTGCCTGTCTT	0.502													49	542					6.03219e-31	9.19251e-31	1	0	A	105419983	A	A	105419983	3	1	141	1	0	0	0	0	1	0	0	0	415	913	32	2	15586	2	AHNAK2	14	105419983	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4804500	105419983	1929557	418	25693											
MKRN3	7681	broad.mit.edu	37	chr15	23811411	23811411	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagtggcggaagccccccCggctgcatcctccctttcct	5	8	11	17	2	0	0	0	0	0	0	3	2	3	2	6	4	2	2	6	4	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:23811411C>A	uc001ywh.3	+	1	958	c.482C>A	c.(481-483)CCG>CAG	p.P161Q	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.P161Q	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	161						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GAAGCCCCCCCGGCTGCATCC	0.642													17	24					1.15088e-07	1.30993e-07	1	0	A	23811411	A	A	23811411	3	1	141	1	0	0	0	0	1	0	0	0	9661	652	23	3	484	3	MKRN3	15	23811411	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08		23811411	78719981	419	25694											
MKRN3	7681	broad.mit.edu	37	chr15	23811593	23811593	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgggttgcatctgcccccGaggctcctctacagagctca	6	9	11	15	1	3	1	1	0	2	1	4	2	4	1	3	2	4	5	3	2	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:23811593G>T	uc001ywh.3	+	1	1140	c.664G>T	c.(664-666)GAG>TAG	p.E222*	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Nonsense_Mutation_p.E222*	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	222						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		ATCTGCCCCCGAGGCTCCTCT	0.597													10	24					0.000978159	0.00102574	1	0	T	23811593	T	T	23811593	4	4	141	1	0	0	0	0	0	1	0	0	9661	1059	37	3	666	3	MKRN3	15	23811593	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	182	23811593	78719799	420	25695											
C15orf2	23742	broad.mit.edu	37	chr15	24922301	24922301	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctttgcccatccctgacttGgctgacctggctactggacc	5	11	9	16	0	0	2	0	2	0	0	1	3	1	3	5	3	2	2	5	3	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:24922301G>T	uc001ywo.2	+	1	1761	c.1287G>T	c.(1285-1287)TTG>TTT	p.L429F		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	429	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TCCCTGACTTGGCTGACCTGG	0.542													32	56					2.08457e-15	2.77816e-15	1	0	T	24922301	T	T	24922301	3	4	141	1	0	0	0	0	1	0	0	0	1790	1339	47	4	1289	4	C15orf2	15	24922301	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1110708	24922301	77609091	421	25696											
GABRA5	2558	broad.mit.edu	37	chr15	27128609	27128609	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctggaccccagacacgttCttccacaacgggaagaagtc	12	7	9	13	2	2	2	0	0	2	2	4	4	3	4	3	2	1	1	3	2	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:27128609C>T	uc001zbd.1	+	7	741	c.402C>T	c.(400-402)TTC>TTT	p.F134F	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	134	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAGACACGTTCTTCCACAACG	0.572													6	47					0	0	0	0	T	27128609	T	T	27128609	2	4	141	1	0	0	0	0	0	0	0	1	6198	912	32	2		2	GABRA5	15	27128609	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2206308	27128609	75402783	422	25697											
MTMR15	22909	broad.mit.edu	37	chr15	31197880	31197880	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcatggagtaacatccaagaGgctcctctgcaggatgacag	12	7	12	10	0	1	2	0	1	1	1	3	4	3	4	2	3	2	4	2	3	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:31197880G>A	uc001zff.2	+	2	1305	c.1014G>A	c.(1012-1014)GAG>GAA	p.E338E	MTMR15_uc001zfc.3_Silent_p.E338E|MTMR15_uc010azw.2_Silent_p.E338E|MTMR15_uc001zfd.3_Silent_p.E338E|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	338					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		ACATCCAAGAGGCTCCTCTGC	0.458								Direct_reversal_of_damage|Editing_and_processing_nucleases					30	68					0	0	0	0	A	31197880	A	A	31197880	2	1	141	1	0	0	0	0	0	0	0	1	9996	991	35	4		4	MTMR15	15	31197880	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4069271	31197880	71333512	423	25698											
SLC12A6	9990	broad.mit.edu	37	chr15	34543234	34543234	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttcgatgatctctcccttgGgtaggtaattactccaaaga	10	14	8	9	1	1	2	0	1	1	1	5	3	3	2	2	2	1	2	2	2	4	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:34543234G>T	uc001zhw.2	-	10	1522	c.1358C>A	c.(1357-1359)CCC>CAC	p.P453H	SLC12A6_uc001zhv.2_Missense_Mutation_p.P402H|SLC12A6_uc001zhx.2_Missense_Mutation_p.P438H|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.P394H|SLC12A6_uc001zib.2_Missense_Mutation_p.P444H|SLC12A6_uc001zic.2_Missense_Mutation_p.P453H|SLC12A6_uc010bau.2_Missense_Mutation_p.P453H|SLC12A6_uc001zid.2_Missense_Mutation_p.P394H|SLC12A6_uc001zht.2_5'Flank|SLC12A6_uc001zhu.2_Missense_Mutation_p.P265H	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	453	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CTCTCCCTTGGGTAGGTAATT	0.383													28	53					2.48696e-23	3.6386e-23	1	0	T	34543234	T	T	34543234	3	4	141	1	0	0	0	0	1	0	0	0	14452	1232	43	4	2158	4	SLC12A6	15	34543234	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3345354	34543234	67988158	424	25699											
C15orf55	256646	broad.mit.edu	37	chr15	34640393	34640393	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggatgggggcccttgcctCagtggggctggggctggcaa	4	7	21	9	0	1	0	1	0	0	0	1	1	1	1	2	9	1	3	2	9	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:34640393C>T	uc001zif.2	+	2	395	c.240C>T	c.(238-240)CTC>CTT	p.L80L	C15orf55_uc010ucc.1_Silent_p.L108L|C15orf55_uc010ucd.1_Silent_p.L98L	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	80	Pro-rich.					cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GCCCTTGCCTCAGTGGGGCTG	0.557			T	BRD3|BRD4	lethal midline carcinoma								29	121					0	0	0	0	T	34640393	T	T	34640393	2	4	141	1	0	0	0	0	0	0	0	1	1809	813	29	2		2	C15orf55	15	34640393	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	97159	34640393	67890999	425	25700											
RASGRP1	10125	broad.mit.edu	37	chr15	38852064	38852064	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgagatcgtccaggctggCtcctttggctaaatgtccca	9	11	10	11	1	0	1	0	1	0	1	4	2	3	1	3	3	0	3	3	3	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:38852064C>T	uc001zke.3	-	2	356	c.178G>A	c.(178-180)GCC>ACC	p.A60T	RASGRP1_uc001zkd.3_Missense_Mutation_p.A60T	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	60	Ras exchanger motif region; required for transforming activity (By similarity).|N-terminal Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TCCAGGCTGGCTCCTTTGGCT	0.502													11	34					0	0	0	0	T	38852064	T	T	38852064	3	4	141	1	0	0	0	0	1	0	0	0	13139	797	28	4	2279	4	RASGRP1	15	38852064	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4211671	38852064	63679328	426	25701											
MAPKBP1	23005	broad.mit.edu	37	chr15	42117604	42117604	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaactgttgcttcgagcCgtggaacggcgtatggaacg	9	9	14	9	5	1	1	1	0	0	1	2	4	1	3	1	3	5	3	1	3	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:42117604C>T	uc001zok.3	+	32	4801	c.4515C>T	c.(4513-4515)GCC>GCT	p.A1505A	MAPKBP1_uc001zoj.3_Silent_p.A1499A|MAPKBP1_uc010bcj.2_Silent_p.A1006A|MAPKBP1_uc010bci.2_Silent_p.A1222A|MAPKBP1_uc010udb.1_Silent_p.A1338A|MAPKBP1_uc010bck.2_Silent_p.A716A|MAPKBP1_uc010bcl.2_Silent_p.A1004A|JMJD7-PLA2G4B_uc010bcm.1_5'Flank|JMJD7-PLA2G4B_uc001zom.2_5'Flank|JMJD7-PLA2G4B_uc001zon.2_5'Flank|JMJD7-PLA2G4B_uc001zoo.3_5'Flank|JMJD7-PLA2G4B_uc010bcn.2_5'Flank	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	1505										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TGCTTCGAGCCGTGGAACGGC	0.607													13	22					0	0	0	0	T	42117604	T	T	42117604	2	4	141	1	0	0	0	0	0	0	0	1	9345	639	23	1		1	MAPKBP1	15	42117604	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3265540	42117604	60413788	427	25702											
PLA2G4E	123745	broad.mit.edu	37	chr15	42278076	42278076	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtagttgaggtggatgatGaggtcggcttttcgctctgg	6	13	16	6	2	1	3	0	3	1	0	3	4	1	4	0	5	0	4	0	5	1	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:42278076G>A	uc001zow.1	-	17	2076	c.2076C>T	c.(2074-2076)CTC>CTT	p.L692L	PLA2G4E_uc010udc.1_Silent_p.L164L|PLA2G4E_uc001zov.1_Silent_p.L345L	NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	709	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		GGTGGATGATGAGGTCGGCTT	0.617													6	10					0	0	0	0	A	42278076	A	A	42278076	2	1	141	1	0	0	0	0	0	0	0	1	12060	1277	45	2		2	PLA2G4E	15	42278076	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	160472	42278076	60253316	428	25703											
TTBK2	146057	broad.mit.edu	37	chr15	43122142	43122142	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaaaggtccctaccggtttGatgtctcgatgcaagaatcc	11	10	10	10	2	1	2	0	1	1	1	4	4	3	2	3	2	2	2	3	2	5	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:43122142G>C	uc001zqo.2	-	5	865	c.426C>G	c.(424-426)ATC>ATG	p.I142M	TTBK2_uc010bcy.2_Missense_Mutation_p.I73M|TTBK2_uc001zqp.2_Missense_Mutation_p.I142M|TTBK2_uc010bcz.1_Missense_Mutation_p.I142M	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	142	Protein kinase.				cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CTACCGGTTTGATGTCTCGAT	0.408													24	65					0	0	0	0	C	43122142	C	C	43122142	3	2	141	1	0	0	0	0	1	0	0	0	16745	1280	45	2	3352	2	TTBK2	15	43122142	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	844066	43122142	59409250	429	25704											
SLC28A2	9153	broad.mit.edu	37	chr15	45560574	45560574	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatacaggggctcactttcCaggtaaaggattacatttgt	12	12	9	8	0	1	0	1	0	0	0	2	1	2	1	1	4	2	2	1	4	4	5	rs142426040	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:45560574C>T	uc001zva.2	+	13	1431	c.1366C>T	c.(1366-1368)CAG>TAG	p.Q456*		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	456	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		GCTCACTTTCCAGGTAAAGGA	0.438													65	97					0	0	0	0	T	45560574	T	T	45560574	4	4	141	1	0	0	0	0	0	1	0	0	14596	595	21	4	1412	4	SLC28A2	15	45560574	Nonsense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2438432	45560574	56970818	430	25705											
SCG3	29106	broad.mit.edu	37	chr15	51984366	51984366	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccactggagactccaatggCagcaattcaagatggtcttg	11	9	10	11	0	2	2	1	0	1	2	3	3	3	2	2	3	1	2	2	3	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:51984366C>A	uc002abh.2	+	7	1109	c.701C>A	c.(700-702)GCA>GAA	p.A234E	SCG3_uc010ufz.1_Missense_Mutation_p.A2E	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	234					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		ACTCCAATGGCAGCAATTCAA	0.378													17	98					1.64113e-05	1.78745e-05	1	0	A	51984366	A	A	51984366	3	1	141	1	0	0	0	0	1	0	0	0	13957	710	25	4	727	4	SCG3	15	51984366	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	6423792	51984366	50547026	431	25706											
UNC13C	440279	broad.mit.edu	37	chr15	54305610	54305610	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggcagctctgacggggaGcgtactctacatggcttaaa	10	8	14	9	2	2	1	0	1	2	0	2	3	2	2	0	4	4	4	0	4	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:54305610G>T	uc002ack.2	+	1	510	c.510G>T	c.(508-510)GAG>GAT	p.E170D		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	170					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CTGACGGGGAGCGTACTCTAC	0.473													25	70					1.42536e-11	1.78902e-11	1	0	T	54305610	T	T	54305610	3	4	141	1	0	0	0	0	1	0	0	0	17054	962	34	4	512	4	UNC13C	15	54305610	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2321244	54305610	48225782	432	25707											
GCOM1	145781	broad.mit.edu	37	chr15	57929944	57929944	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacatgaaacagaaatgtctGgggagttaactgattctgac	15	10	10	6	0	2	4	0	3	2	1	2	5	2	5	0	2	3	1	0	2	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:57929944G>A	uc002aei.2	+	9	1104	c.985G>A	c.(985-987)GGG>AGG	p.G329R	GCOM1_uc002aej.2_Missense_Mutation_p.G329R|GCOM1_uc002aek.2_RNA|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Missense_Mutation_p.G329R|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Missense_Mutation_p.G329R|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	329	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						AGAAATGTCTGGGGAGTTAAC	0.383													6	9					0	0	0	0	A	57929944	A	A	57929944	3	1	141	1	0	0	0	0	1	0	0	0	6340	1348	47	4	1019	4	GCOM1	15	57929944	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3624334	57929944	44601448	433	25708											
NOX5	79400	broad.mit.edu	37	chr15	69347810	69347810	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacggggctgcagacgcgCacccagcctgggcggcctga	7	4	15	15	4	1	2	1	1	0	1	1	2	1	2	3	4	2	3	3	4	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:69347810C>T	uc002ars.1	+	15	2156	c.2136C>T	c.(2134-2136)CGC>CGT	p.R712R	NOX5_uc002arp.1_Silent_p.R694R|NOX5_uc002arq.1_Silent_p.R666R|NOX5_uc010bid.1_Silent_p.R677R|NOX5_uc002arr.1_Silent_p.R684R|NOX5_uc010bie.1_Silent_p.R512R|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	712	Extracellular (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						TGCAGACGCGCACCCAGCCTG	0.607													18	27					0	0	0	0	T	69347810	T	T	69347810	2	4	141	1	0	0	0	0	0	0	0	1	10613	697	25	4		4	NOX5	15	69347810	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	11417866	69347810	33183582	434	25709											
ISL2	64843	broad.mit.edu	37	chr15	76630854	76630854	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccgcggcctgcatctgccCggtaagcgcgccggggcctg	3	5	16	17	6	1	0	0	0	1	0	1	0	1	0	5	4	3	2	5	4	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:76630854C>A	uc002bbw.1	+	3	588	c.510C>A	c.(508-510)CCC>CCA	p.P170P		NM_145805	NP_665804	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	170						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGCATCTGCCCGGTAAGCGCG	0.468													18	22					3.52763e-06	3.91188e-06	1	0	A	76630854	A	A	76630854	2	1	141	1	0	0	0	0	0	0	0	1	7896	666	23	3		3	ISL2	15	76630854	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	7283044	76630854	25900538	435	25710											
IREB2	3658	broad.mit.edu	37	chr15	78758820	78758820	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgtgtccttttcatttgcaAccagtgcctgagtatgagat	8	15	9	9	0	1	2	1	2	0	1	2	3	2	2	3	0	3	2	3	0	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:78758820A>G	uc002bdr.2	+	5	780	c.618A>G	c.(616-618)CAA>CAG	p.Q206Q	IREB2_uc010unb.1_5'UTR|IREB2_uc002bdq.2_Silent_p.Q206Q	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	206							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		TTCATTTGCAACCAGTGCCTG	0.383													23	51					0	0	0	0	G	78758820	G	G	78758820	2	3	141	1	0	0	0	0	0	0	0	1	7865	40	2	5		5	IREB2	15	78758820	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	2127966	78758820	23772572	436	25711											
IREB2	3658	broad.mit.edu	37	chr15	78765606	78765606	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttggaggcattgaaacagaAgcagttatgcttggtctgcc	10	11	13	7	0	1	2	0	1	1	1	1	3	1	3	1	3	4	5	1	3	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:78765606A>G	uc002bdr.2	+	8	1068	c.906A>G	c.(904-906)GAA>GAG	p.E302E	IREB2_uc010unb.1_Silent_p.E52E|IREB2_uc002bdq.2_Silent_p.E302E	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	302							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		TTGAAACAGAAGCAGTTATGC	0.388													50	117					0	0	0	0	G	78765606	G	G	78765606	2	3	141	1	0	0	0	0	0	0	0	1	7865	69	3	5		5	IREB2	15	78765606	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	6786	78765606	23765786	437	25712											
ADAMTS7	11173	broad.mit.edu	37	chr15	79059741	79059741	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgagaccagttccccacagCccaggtggccggacagggta	9	5	13	14	1	0	1	0	1	0	1	1	3	1	2	5	4	1	2	5	4	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:79059741C>A	uc002bej.3	-	18	3050	c.2839G>T	c.(2839-2841)GCT>TCT	p.A947S	ADAMTS7_uc010und.1_Intron	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	947	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						TTCCCCACAGCCCAGGTGGCC	0.652													16	19					9.16793e-09	1.07867e-08	1	0	A	79059741	A	A	79059741	3	1	141	1	0	0	0	0	1	0	0	0	271	739	26	4	2249	4	ADAMTS7	15	79059741	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	294135	79059741	23471651	438	25713											
ZFAND6	54469	broad.mit.edu	37	chr15	80423525	80423525	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcgtatttttgttagcttCagtatcagacacagcacagc	10	14	7	10	1	2	1	2	0	0	1	3	1	2	1	0	0	3	5	0	0	3	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:80423525C>T	uc002bfe.1	+	6	679	c.368C>T	c.(367-369)TCA>TTA	p.S123L	ZFAND6_uc002bff.1_Missense_Mutation_p.S123L|ZFAND6_uc002bfg.1_Missense_Mutation_p.S111L|ZFAND6_uc002bfh.1_Missense_Mutation_p.S123L|ZFAND6_uc002bfi.1_Missense_Mutation_p.S123L	NM_019006	NP_061879	Q6FIF0	ZFAN6_HUMAN	zinc finger, AN1-type domain 6	123							DNA binding|zinc ion binding				0						TTGTTAGCTTCAGTATCAGAC	0.393													9	94					0	0	0	0	T	80423525	T	T	80423525	3	4	141	1	0	0	0	0	1	0	0	0	17698	838	29	2	382	2	ZFAND6	15	80423525	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1363784	80423525	22107867	439	25714											
ZNF592	9640	broad.mit.edu	37	chr15	85326320	85326320	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagagccattacccaccttCaaccagttcagtccaatctc	11	10	4	16	0	4	1	3	0	1	1	6	1	5	1	5	0	3	1	5	0	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:85326320C>T	uc002bld.2	+	4	750	c.414C>T	c.(412-414)TTC>TTT	p.F138F	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	138					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TACCCACCTTCAACCAGTTCA	0.478													42	139					0	0	0	0	T	85326320	T	T	85326320	2	4	141	1	0	0	0	0	0	0	0	1	18089	825	29	2		2	ZNF592	15	85326320	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4902795	85326320	17205072	440	25715											
SLC28A1	9154	broad.mit.edu	37	chr15	85431063	85431063	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaagggtctggagaacatGggggctgatttcttggaaag	10	9	16	6	0	2	2	0	1	2	1	2	4	2	3	1	5	1	1	1	5	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:85431063G>T	uc002blg.2	+	3	274	c.72G>T	c.(70-72)ATG>ATT	p.M24I	SLC28A1_uc010upd.1_5'UTR|SLC28A1_uc010bnb.2_Missense_Mutation_p.M24I|SLC28A1_uc010upe.1_Missense_Mutation_p.M24I|SLC28A1_uc010upf.1_Missense_Mutation_p.M24I|SLC28A1_uc010upg.1_Missense_Mutation_p.M24I|SLC28A1_uc002blf.2_Missense_Mutation_p.M24I	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	24					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGGAGAACATGGGGGCTGATT	0.567													31	50					1.82574e-34	2.79973e-34	1	0	T	85431063	T	T	85431063	3	4	141	1	0	0	0	0	1	0	0	0	14595	1348	47	4	74	4	SLC28A1	15	85431063	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	104743	85431063	17100329	441	25716											
RHCG	51458	broad.mit.edu	37	chr15	90019999	90019999	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aactcacctcccagtagaccGcatcctcaaagcagttctca	12	8	5	16	1	3	1	3	0	1	1	6	1	5	1	4	0	2	4	4	0	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:90019999G>T	uc002bnz.2	-	9	1322	c.1298C>A	c.(1297-1299)GCG>GAG	p.A433E	RHCG_uc002bny.2_Missense_Mutation_p.A204E|RHCG_uc002boa.2_RNA	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	433	Cytoplasmic (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					CCAGTAGACCGCATCCTCAAA	0.562													26	50					2.08973e-25	3.10075e-25	1	0	T	90019999	T	T	90019999	3	4	141	1	0	0	0	0	1	0	0	0	13391	1087	38	3	149	3	RHCG	15	90019999	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4588936	90019999	12511393	442	25717											
TELO2	9894	broad.mit.edu	37	chr16	1552736	1552736	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgcgccagagagccctggtgGccgtcacggtcacagacccg	7	5	14	15	4	2	2	2	0	0	2	2	3	2	2	4	3	2	0	4	3	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:1552736G>T	uc002cly.2	+	14	2035	c.1744G>T	c.(1744-1746)GCC>TCC	p.A582S		NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	582						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				AGCCCTGGTGGCCGTCACGGT	0.672													33	92					1.58521e-26	2.37134e-26	1	0	T	1552736	T	T	1552736	3	4	141	1	0	0	0	0	1	0	0	0	15823	1203	42	4	1794	4	TELO2	16	1552736	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08		1552736	88802017	443	25718											
ZNF200	7752	broad.mit.edu	37	chr16	3274518	3274518	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgagagaccaaggaagaatCcatttcatcatcatctgaag	15	9	8	9	0	4	4	3	2	1	2	5	6	5	5	2	1	0	0	2	1	4	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:3274518C>T	uc002cuj.2	-	5	1194	c.562G>A	c.(562-564)GAT>AAT	p.D188N	ZNF200_uc002cum.3_Missense_Mutation_p.D187N|ZNF200_uc010bti.2_Missense_Mutation_p.D187N|ZNF200_uc002cuk.2_Missense_Mutation_p.D188N|ZNF200_uc002cui.2_Missense_Mutation_p.D187N|ZNF200_uc002cul.3_Missense_Mutation_p.D187N	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AAGGAAGAATCCATTTCATCA	0.398													34	57					0	0	0	0	T	3274518	T	T	3274518	3	4	141	1	0	0	0	0	1	0	0	0	17829	855	30	2	629	2	ZNF200	16	3274518	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1721782	3274518	87080235	444	25719											
A2BP1	54715	broad.mit.edu	37	chr16	7102088	7102088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacagatgaattgtgaaagaGagcagctaagggtaggtgca	16	7	14	4	0	0	4	0	2	0	2	0	5	0	4	0	2	4	4	0	2	5	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:7102088G>A	uc002cys.2	+	4	1004	c.16G>A	c.(16-18)GAG>AAG	p.E6K	A2BP1_uc010buf.1_Missense_Mutation_p.E6K|A2BP1_uc002cyr.1_Missense_Mutation_p.E6K|A2BP1_uc002cyt.2_Missense_Mutation_p.E6K|A2BP1_uc010uxz.1_Missense_Mutation_p.E49K|A2BP1_uc010uya.1_Missense_Mutation_p.E42K|A2BP1_uc002cyv.1_Missense_Mutation_p.E6K|A2BP1_uc010uyb.1_Missense_Mutation_p.E6K	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	6					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TTGTGAAAGAGAGCAGCTAAG	0.398													8	17					0	0	0	0	A	7102088	A	A	7102088	3	1	141	1	0	0	0	0	1	0	0	0	3	943	33	2	18	2	A2BP1	16	7102088	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3827570	7102088	83252665	445	25720											
GRIN2A	2903	broad.mit.edu	37	chr16	9923430	9923430	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtggtccctttaggattctgGacaggcacggagttattgaa	9	12	13	7	1	1	1	0	1	1	0	2	4	2	4	1	5	0	2	1	5	3	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:9923430G>T	uc002czo.3	-	9	2405	c.1857C>A	c.(1855-1857)GTC>GTA	p.V619V	GRIN2A_uc010uym.1_Silent_p.V619V|GRIN2A_uc010uyn.1_Silent_p.V462V|GRIN2A_uc002czr.3_Silent_p.V619V	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	619	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TAGGATTCTGGACAGGCACGG	0.488													34	64					4.3181e-19	6.01743e-19	1	0	T	9923430	T	T	9923430	2	4	141	1	0	0	0	0	0	0	0	1	6818	1161	41	2		2	GRIN2A	16	9923430	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2821342	9923430	80431323	446	25721											
GPR139	124274	broad.mit.edu	37	chr16	20043241	20043241	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgtggcggctgccatggtgCggaaccgcttgctgatgaag	6	8	17	10	4	0	2	0	2	0	0	0	3	0	3	2	4	4	3	2	4	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:20043241C>T	uc002dgu.1	-	2	1040	c.878G>A	c.(877-879)CGC>CAC	p.R293H	GPR139_uc010vaw.1_Missense_Mutation_p.R200H	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	293	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						TGCCATGGTGCGGAACCGCTT	0.512													51	98					0	0	0	0	T	20043241	T	T	20043241	3	4	141	1	0	0	0	0	1	0	0	0	6686	768	27	1	187	1	GPR139	16	20043241	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	10119811	20043241	70311512	447	25722											
OTOA	146183	broad.mit.edu	37	chr16	21696600	21696600	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcaccagccccagaagcTgctggaggacctgaggaaga	11	5	13	12	0	1	3	0	1	1	2	1	6	1	6	4	3	4	3	4	3	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:21696600T>A	uc002djh.2	+	6	318	c.317T>A	c.(316-318)CTG>CAG	p.L106Q	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.L27Q	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	106					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		CCCCAGAAGCTGCTGGAGGAC	0.577													28	32					0	0	0	0	A	21696600	A	A	21696600	3	1	141	1	0	0	0	0	1	0	0	0	11356	1580	55	5	373	5	OTOA	16	21696600	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	1653359	21696600	68658153	448	25723											
EEF2K	29904	broad.mit.edu	37	chr16	22271832	22271832	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcatccagagaccatgaTcatctagacaaccaccgggt	13	7	9	12	1	2	3	1	1	1	2	3	4	3	3	4	2	1	1	4	2	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:22271832T>G	uc002dki.2	+	11	1766	c.1281T>G	c.(1279-1281)GAT>GAG	p.D427E	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	427					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		GAGACCATGATCATCTAGACA	0.542													60	91					0	0	0	0	G	22271832	G	G	22271832	3	3	141	1	0	0	0	0	1	0	0	0	4952	1432	50	5	1319	5	EEF2K	16	22271832	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	575232	22271832	68082921	449	25724											
PALB2	79728	broad.mit.edu	37	chr16	23647270	23647270	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttcagatttaagacttaaAaggtgagttcttatttcagt	13	16	8	4	0	3	3	2	1	1	2	3	3	3	3	0	1	0	2	0	1	4	7			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:23647270A>C	uc002dlx.1	-	4	797	c.597T>G	c.(595-597)CTT>CTG	p.L199L		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	199	Interaction with RAD51.|Interaction with BRCA1.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		TAAGACTTAAAAGGTGAGTTC	0.378			F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				93	135					0	0	0	0	C	23647270	C	C	23647270	2	2	141	1	0	0	0	0	0	0	0	1	11460	1	1	5		5	PALB2	16	23647270	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	1375438	23647270	66707483	450	25725											
TNRC6A	27327	broad.mit.edu	37	chr16	24800997	24800997	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caacaatagaatgaatgcttGgggcactgtaagttcttcat	13	12	9	7	0	2	2	1	1	1	1	2	2	2	2	0	2	2	4	0	2	6	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:24800997G>C	uc002dmm.2	+	6	1148	c.1034G>C	c.(1033-1035)TGG>TCG	p.W345S	TNRC6A_uc010bxs.2_Missense_Mutation_p.W92S|TNRC6A_uc010vcc.1_Missense_Mutation_p.W92S|TNRC6A_uc002dmn.2_Missense_Mutation_p.W92S|TNRC6A_uc002dmo.2_Missense_Mutation_p.W92S	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	345	Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C1, EIF2C3 and EIF2C4.|Sufficient for interaction with EIF2C2.|Ser-rich.|Sufficient for interaction with EIF2C2.			W->A: Does not impair interaction with EIF2C2; when associated with A-313; A- 370; A-420 and A-483.	negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		ATGAATGCTTGGGGCACTGTA	0.438													45	101					0	0	0	0	C	24800997	C	C	24800997	3	2	141	1	0	0	0	0	1	0	0	0	16406	1357	47	4	1056	4	TNRC6A	16	24800997	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1153727	24800997	65553756	451	25726											
C16orf93	90835	broad.mit.edu	37	chr16	30770417	30770417	+	Missense_Mutation	SNP	C	T	T																															ctccatctccttgctttcttCtttctctgcaaaccagaagc																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:30770417C>T	uc002dzm.2	-	8	1064	c.733G>A	c.(733-735)GAA>AAA	p.E245K	C16orf93_uc002dzn.2_Missense_Mutation_p.E310K|C16orf93_uc002dzo.2_Missense_Mutation_p.E208K	NM_001014979	NP_001014979	A1A4V9	CP093_HUMAN	hypothetical protein LOC90835	245											0						TTGCTTTCTTCTTTCTCTGCA	0.597													163	144					0	0	0	0	T	30770417	T	T	30770417	3	4	141	1	0	0	0	0	1	0	0	0	1852	922	32	2	270	2	C16orf93	16	30770417	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	5969420	30770417	59584336	452	25727	51	2									
C16orf93	90835	broad.mit.edu	37	chr16	30770423	30770423	+	Splice_Site	SNP	C	T	T																															ctccttgctttcttctttctCtgcaaaccagaagcaggaag																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:30770423C>T	uc002dzm.2	-	8	1059	c.728_splice	c.e8-1	p.E243_splice	C16orf93_uc002dzn.2_Splice_Site_p.E308_splice|C16orf93_uc002dzo.2_Splice_Site_p.E206_splice	NM_001014979	NP_001014979	A1A4V9	CP093_HUMAN	hypothetical protein LOC90835												0						TCTTCTTTCTCTGCAAACCAG	0.587													148	139					0	0	0	0	T	30770423	T	T	30770423	5	4	141	1	0	0	0	0	0	0	1	0	1852	927	32	2	276	2	C16orf93	16	30770423	Splice_Site	SNP	C	TCGA-CR-7370-01A-11D-2129-08	6	30770423	59584330	453	25728	51	2									
C16orf93	90835	broad.mit.edu	37	chr16	30771764	30771764	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaccctagctccagcagctCagccagcacccttgggaggg	9	5	11	16	0	1	0	1	0	0	0	2	1	2	1	4	2	5	4	4	2	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:30771764C>G	uc002dzm.2	-	4	641	c.310G>C	c.(310-312)GAG>CAG	p.E104Q	C16orf93_uc002dzn.2_Missense_Mutation_p.E104Q|C16orf93_uc002dzo.2_Missense_Mutation_p.E67Q|C16orf93_uc002dzp.2_Missense_Mutation_p.E104Q|RNF40_uc002dzq.2_5'Flank|RNF40_uc010caa.2_5'Flank|RNF40_uc010cab.2_5'Flank|RNF40_uc010vfa.1_5'Flank|RNF40_uc002dzr.2_5'Flank|RNF40_uc010vfb.1_5'Flank	NM_001014979	NP_001014979	A1A4V9	CP093_HUMAN	hypothetical protein LOC90835	104											0						TCCAGCAGCTCAGCCAGCACC	0.597													33	40					0	0	0	0	G	30771764	G	G	30771764	3	3	141	1	0	0	0	0	1	0	0	0	1852	835	29	2	709	2	C16orf93	16	30771764	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1341	30771764	59582989	454	25729											
PRSS8	5652	broad.mit.edu	37	chr16	31143906	31143906	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgcagtggcttgggcgtCaggaggctcactgtgggggt	4	10	19	8	1	2	0	2	0	0	0	2	1	2	1	0	6	2	4	0	6	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:31143906C>T	uc002ebc.3	-	5	881	c.549G>A	c.(547-549)CTG>CTA	p.L183L	PRSS8_uc010vfe.1_Silent_p.L129L	NM_002773	NP_002764	Q16651	PRSS8_HUMAN	prostasin preproprotein	183	Peptidase S1.				proteolysis	extracellular space|integral to membrane|plasma membrane	serine-type endopeptidase activity				0						GCTTGGGCGTCAGGAGGCTCA	0.612													37	40					0	0	0	0	T	31143906	T	T	31143906	2	4	141	1	0	0	0	0	0	0	0	1	12697	813	29	2		2	PRSS8	16	31143906	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	372142	31143906	59210847	455	25730											
CDH1	999	broad.mit.edu	37	chr16	68842735	68842735	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagcctctggatagagaacGcattgccacatacactgtaa	14	8	9	10	1	1	2	0	0	1	2	1	4	1	3	2	1	4	2	2	1	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:68842735G>A	uc002ewg.1	+	5	795	c.671G>A	c.(670-672)CGC>CAC	p.R224H	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.R224H	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	224	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GATAGAGAACGCATTGCCACA	0.483			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				4	30					0	0	0	0	A	68842735	A	A	68842735	3	1	141	1	0	0	0	0	1	0	0	0	3110	1087	38	1	689	1	CDH1	16	68842735	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	37698829	68842735	21512018	456	25731											
ZBTB4	57659	broad.mit.edu	37	chr17	7366417	7366417	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctccatctcctctccgctCagctccccaggacgcaggtc	5	9	7	20	2	3	0	1	0	2	0	9	1	6	1	6	2	1	3	6	2	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:7366417C>A	uc002ghc.3	-	4	2134	c.1884G>T	c.(1882-1884)CTG>CTT	p.L628L	ZBTB4_uc002ghd.3_Silent_p.L628L	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	628	Glu-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		cctcTCCGCTCAGCTCCCCAG	0.398													6	7					0.00307968	0.00320654	1	0	A	7366417	A	A	7366417	2	1	141	1	0	0	0	0	0	0	0	1	17608	813	29	2		2	ZBTB4	17	7366417	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08		7366417	73828793	457	25732											
TP53	7157	broad.mit.edu	37	chr17	7577569	7577569	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccatgcaggaactgttacAcatgtagttgtagtggatgg	10	11	13	7	0	0	0	0	0	0	0	0	2	0	2	1	3	3	5	1	3	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:7577569A>T	uc002gim.2	-	7	906	c.712T>A	c.(712-714)TGT>AGT	p.C238S	TP53_uc002gig.1_Missense_Mutation_p.C238S|TP53_uc002gih.2_Missense_Mutation_p.C238S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106S|TP53_uc010cng.1_Missense_Mutation_p.C106S|TP53_uc002gii.1_Missense_Mutation_p.C106S|TP53_uc010cnh.1_Missense_Mutation_p.C238S|TP53_uc010cni.1_Missense_Mutation_p.C238S|TP53_uc002gij.2_Missense_Mutation_p.C238S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145S|TP53_uc002gio.2_Missense_Mutation_p.C106S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(32)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238del(1)|p.C238G(1)|p.C238fs*21(1)|p.C238C(1)|p.M237fs*1(1)|p.H233fs*6(1)|p.H233_C242del10(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAACTGTTACACATGTAGTTG	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	54					0	0	0	0	T	7577569	T	T	7577569	3	4	141	1	0	0	0	0	1	0	0	0	16448	159	6	5	578	5	TP53	17	7577569	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	211152	7577569	73617641	458	25733											
DNAH2	146754	broad.mit.edu	37	chr17	7662908	7662908	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtcattttgaagaatgatCtgcaaggaagtgtggcacag	12	12	12	5	0	2	3	1	2	1	1	2	4	2	4	0	2	1	2	0	2	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:7662908C>G	uc002giu.1	+	15	2631	c.2617C>G	c.(2617-2619)CTG>GTG	p.L873V		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	873	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GAAGAATGATCTGCAAGGAAG	0.448													10	98					0	0	0	0	G	7662908	G	G	7662908	3	3	141	1	0	0	0	0	1	0	0	0	4624	912	32	2	2675	2	DNAH2	17	7662908	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	85339	7662908	73532302	459	25734											
CHD3	1107	broad.mit.edu	37	chr17	7814256	7814256	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctggccgccgcaggcgccaAttacagccagatgcctgcag	8	5	12	16	3	0	1	0	0	0	1	0	1	0	1	6	2	4	2	6	2	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:7814256A>G	uc002gje.2	+	39	5996	c.5846A>G	c.(5845-5847)AAT>AGT	p.N1949S	CHD3_uc002gjd.2_Missense_Mutation_p.N2008S|CHD3_uc002gjf.2_Missense_Mutation_p.N1915S|CHD3_uc002gjh.2_Missense_Mutation_p.N526S|CHD3_uc002gjj.2_Missense_Mutation_p.N112S	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1949	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GCAGGCGCCAATTACAGCCAG	0.632													63	92					0	0	0	0	G	7814256	G	G	7814256	3	3	141	1	0	0	0	0	1	0	0	0	3341	101	4	5	6281	5	CHD3	17	7814256	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	151348	7814256	73380954	460	25735											
MYH10	4628	broad.mit.edu	37	chr17	8451705	8451705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatttccaaactgtagcactGaagatactactttaagcatt	14	14	5	8	0	0	2	0	1	0	1	1	2	1	2	1	0	5	3	1	0	7	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:8451705G>A	uc002gll.2	-	10	1151	c.1055C>T	c.(1054-1056)TCA>TTA	p.S352L	MYH10_uc002glm.2_Missense_Mutation_p.S362L|MYH10_uc010cnx.2_Missense_Mutation_p.S361L	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	352	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CTGTAGCACTGAAGATACTAC	0.299													52	49					0	0	0	0	A	8451705	A	A	8451705	3	1	141	1	0	0	0	0	1	0	0	0	10083	1294	45	2	5003	2	MYH10	17	8451705	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	637449	8451705	72743505	461	25736											
GLP2R	9340	broad.mit.edu	37	chr17	9792910	9792910	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggggagctgggcgcccagcCccaacaggaccatgcacgct	8	4	14	15	2	0	0	0	0	0	0	0	2	0	2	4	4	4	3	4	4	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:9792910C>A	uc002gmd.1	+	13	1550	c.1550C>A	c.(1549-1551)CCC>CAC	p.P517H		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	517	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	GGCGCCCAGCCCCAACAGGAC	0.632													24	29					1.10923e-09	1.3329e-09	1	0	A	9792910	A	A	9792910	3	1	141	1	0	0	0	0	1	0	0	0	6490	623	22	4	1600	4	GLP2R	17	9792910	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1341205	9792910	71402300	462	25737											
MYH13	8735	broad.mit.edu	37	chr17	10206572	10206572	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcagcttgtccaccaggtCctggagcctaaggatattct	8	11	10	12	0	1	0	0	0	1	0	3	2	3	2	4	3	3	2	4	3	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10206572C>A	uc002gmk.1	-	39	5698	c.5608G>T	c.(5608-5610)GAC>TAC	p.D1870Y		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1870	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCCACCAGGTCCTGGAGCCTA	0.582													92	154					1.11883e-47	1.75987e-47	1	0	A	10206572	A	A	10206572	3	1	141	1	0	0	0	0	1	0	0	0	10085	855	30	2	220	2	MYH13	17	10206572	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	413662	10206572	70988638	463	25738											
MYH8	4626	broad.mit.edu	37	chr17	10310220	10310220	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgtcttaccaggagttttgGtttcattgggaatgatacac	9	15	11	6	0	2	1	1	1	1	0	2	3	2	3	1	3	2	2	1	3	3	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10310220G>A	uc002gmm.2	-	18	2137	c.2042C>T	c.(2041-2043)ACC>ATC	p.T681I	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	681	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						AGGAGTTTTGGTTTCATTGGG	0.388									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				8	65					0	0	0	0	A	10310220	A	A	10310220	3	1	141	1	0	0	0	0	1	0	0	0	10094	1261	44	4	3863	4	MYH8	17	10310220	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	103648	10310220	70884990	464	25739											
MYH4	4622	broad.mit.edu	37	chr17	10351938	10351938	+	Frame_Shift_Del	DEL	G	-	-																															tgattacagtgactcacgttGtaagttcttattctctcgct																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10351938delG	uc002gmn.2	-	32	4639	c.4528delC	c.(4528-4530)CAAfs	p.Q1510fs	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1510	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GACTCACGTTGTAAGTTCTTA	0.378													---	---	---								-	10351938	-	-	10351938	7	5	141	1	0	1	0	1	0	0	0	0	10090	1386	48	0	1327	0	MYH4	17	10351938	Frame_Shift_Del	DEL	G	TCGA-CR-7370-01A-11D-2129-08	41718	10351938	70843272	465	25740											
MYH4	4622	broad.mit.edu	37	chr17	10364260	10364260	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatctggctctgcctgctCttccctttgcttttgcttga	2	17	8	14	0	3	1	0	1	3	0	4	1	4	1	3	1	4	4	3	1	0	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10364260C>A	uc002gmn.2	-	12	1231	c.1120G>T	c.(1120-1122)GAG>TAG	p.E374*	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	374	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TCTGCCTGCTCTTCCCTTTGC	0.493													50	89					9.22156e-22	1.3202e-21	1	0	A	10364260	A	A	10364260	4	1	141	1	0	0	0	0	0	1	0	0	10090	922	32	2	4815	2	MYH4	17	10364260	Nonsense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	12322	10364260	70830950	466	25741											
MYH4	4622	broad.mit.edu	37	chr17	10366498	10366498	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagtaactcgggacttctcTagcagatctggaagtcagat	13	10	10	8	1	3	2	1	0	2	2	5	4	3	4	0	2	2	2	0	2	4	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10366498T>C	uc002gmn.2	-	10	924	c.813A>G	c.(811-813)CTA>CTG	p.L271L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	271	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GGGACTTCTCTAGCAGATCTG	0.353													26	43					0	0	0	0	C	10366498	C	C	10366498	2	2	141	1	0	0	0	0	0	0	0	1	10090	1509	53	5		5	MYH4	17	10366498	Silent	SNP	T	TCGA-CR-7370-01A-11D-2129-08	2238	10366498	70828712	467	25742											
MYH3	4621	broad.mit.edu	37	chr17	10554888	10554888	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgtggggtggggcctccTggcgctttttgcctcggtag	3	12	17	9	2	0	1	0	0	0	1	2	1	1	1	3	6	1	2	3	6	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10554888T>A	uc002gmq.1	-	4	523	c.446A>T	c.(445-447)CAG>CTG	p.Q149L		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	149	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TGGGGCCTCCTGGCGCTTTTT	0.577													86	180					0	0	0	0	A	10554888	A	A	10554888	3	1	141	1	0	0	0	0	1	0	0	0	10089	1580	55	5	5524	5	MYH3	17	10554888	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	188390	10554888	70640322	468	25743											
MYO15A	51168	broad.mit.edu	37	chr17	18030103	18030103	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctaatgacctgtctccccAggcacctctttgctgttgca	6	13	7	15	0	3	1	0	1	3	0	4	1	3	1	4	1	2	4	4	1	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:18030103A>G	uc010vxh.1	+	6	4205	c.3867_splice	c.e6-2	p.P1289_splice		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV						sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CTGTCTCCCCAGGCACCTCTT	0.552													52	97					0	0	0	0	G	18030103	G	G	18030103	5	3	141	1	0	0	0	0	0	0	1	0	10116	202	7	5	3883	5	MYO15A	17	18030103	Splice_Site	SNP	A	TCGA-CR-7370-01A-11D-2129-08	7475215	18030103	63165107	469	25744											
FBXW10	10517	broad.mit.edu	37	chr17	18653137	18653137	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacgatccctgcaatctatTggttgacctggatgacatca	10	12	9	10	1	2	2	1	2	1	0	3	4	3	3	2	2	2	3	2	2	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:18653137T>C	uc002guk.2	+	3	1005	c.773T>C	c.(772-774)TTG>TCG	p.L258S	FBXW10_uc002guj.2_Missense_Mutation_p.L258S|FBXW10_uc002gul.2_Missense_Mutation_p.L258S|FBXW10_uc010cqh.1_Missense_Mutation_p.L258S	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	258										ovary(1)	1						TGCAATCTATTGGTTGACCTG	0.468													50	162					0	0	0	0	C	18653137	C	C	18653137	3	2	141	1	0	0	0	0	1	0	0	0	5795	1821	63	5	783	5	FBXW10	17	18653137	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	623034	18653137	62542073	470	25745											
MAP2K3	5606	broad.mit.edu	37	chr17	21205550	21205550	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgacaattccagaggacatCcttggggagattgctgtgtc	10	11	12	8	0	0	3	0	1	0	2	3	5	2	4	2	3	1	1	2	3	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:21205550C>A	uc002gys.2	+	6	760	c.495C>A	c.(493-495)ATC>ATA	p.I165I	MAP2K3_uc002gyt.2_Silent_p.I136I|MAP2K3_uc002gyu.2_Silent_p.I136I	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	165	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CAGAGGACATCCTTGGGGAGA	0.582													16	52					6.49762e-13	8.3704e-13	1	0	A	21205550	A	A	21205550	2	1	141	1	0	0	0	0	0	0	0	1	9291	845	30	2		2	MAP2K3	17	21205550	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2552413	21205550	59989660	471	25746											
KCNJ12	3768	broad.mit.edu	37	chr17	21318731	21318732	+	Missense_Mutation	DNP	CG	TC	TC																															gctgcacctggtcaccatgtCgggcgccaacggcttcggca																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:21318731_21318732CG>TC	uc002gyv.1	+	3	782_783	c.77_78CG>TC	c.(76-78)TCG>TTC	p.S26F		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	26	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	GTCACCATGTCGGGCGCCAACG	0.658										Prostate(3;0.18)			4	45					0	0	0	0	TC	21318732	TC	TC	21318731	3	4	141	1	0	0	0	0	1	0	0	0	8085	893	31	1	79	1	KCNJ12	17	21318731	Missense_Mutation	DNP	CG	TCGA-CR-7370-01A-11D-2129-08	113181	21318731	59876479	472	25747											
NOS2	4843	broad.mit.edu	37	chr17	26084314	26084314	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgctgggctgcaccgccacCctgtccttcttcgcctcgta	3	11	9	18	3	1	0	0	0	1	0	4	0	2	0	5	1	2	4	5	1	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:26084314C>A	uc002gzu.2	-	27	3684	c.3420G>T	c.(3418-3420)AGG>AGT	p.R1140S		NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	1140					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GCACCGCCACCCTGTCCTTCT	0.537											OREG0024267	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	57					4.527e-37	6.98588e-37	1	0	A	26084314	A	A	26084314	3	1	141	1	0	0	0	0	1	0	0	0	10597	622	22	4	45	4	NOS2	17	26084314	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4765583	26084314	55110896	473	25748											
SUPT6H	6830	broad.mit.edu	37	chr17	27008409	27008409	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagcgtgtcagggaagaGggagatgaagaaggttagtg	13	7	18	3	1	1	5	1	2	0	3	1	7	1	6	0	3	1	1	0	3	5	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:27008409G>T	uc002hby.2	+	12	1575	c.1485G>T	c.(1483-1485)GAG>GAT	p.E495D	SUPT6H_uc010crt.2_Missense_Mutation_p.E495D	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	495					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TCAGGGAAGAGGGAGATGAAG	0.338													24	41					6.12954e-19	8.47726e-19	1	0	T	27008409	T	T	27008409	3	4	141	1	0	0	0	0	1	0	0	0	15466	991	35	4	1527	4	SUPT6H	17	27008409	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	924095	27008409	54186801	474	25749											
ACCN1	40	broad.mit.edu	37	chr17	31340990	31340990	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gactcgaggggtgtcagcagGcaatctcctccaaggtcccc	8	7	12	14	1	2	0	1	0	1	0	6	2	4	0	4	4	1	2	4	4	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:31340990G>T	uc002hhu.2	-	10	1806	c.1532C>A	c.(1531-1533)GCC>GAC	p.A511D	ACCN1_uc002hht.2_Missense_Mutation_p.A562D	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	511	Cytoplasmic (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	GTGTCAGCAGGCAATCTCCTC	0.572													4	6					1.23904e-05	1.35555e-05	1	0	T	31340990	T	T	31340990	3	4	141	1	0	0	0	0	1	0	0	0	128	1203	42	4	10	4	ACCN1	17	31340990	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4332581	31340990	49854220	475	25750											
CCL1	6346	broad.mit.edu	37	chr17	32690143	32690143	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttccggccacatcccagctAgcagcaagcacaccagggct	10	5	9	17	1	0	0	0	0	0	0	2	0	2	0	4	2	4	5	4	2	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:32690143A>T	uc002hid.1	-	1	110	c.38T>A	c.(37-39)CTA>CAA	p.L13Q		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	13					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		CATCCCAGCTAGCAGCAAGCA	0.562													20	30					0	0	0	0	T	32690143	T	T	32690143	3	4	141	1	0	0	0	0	1	0	0	0	2895	420	15	5	264	5	CCL1	17	32690143	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	1349153	32690143	48505067	476	25751											
SLFN13	146857	broad.mit.edu	37	chr17	33768373	33768373	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccgggtctctgctcggcaGatatttctatcactgtaaaa	9	13	8	11	2	3	1	1	0	2	1	6	1	4	1	1	2	1	3	1	2	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:33768373G>A	uc002hjk.1	-	4	2265	c.1935C>T	c.(1933-1935)ATC>ATT	p.I645I	SLFN13_uc010wch.1_Silent_p.I645I|SLFN13_uc002hjl.2_Silent_p.I645I|SLFN13_uc010ctt.2_Silent_p.I327I|SLFN13_uc002hjm.2_Silent_p.I314I	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	645						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTGCTCGGCAGATATTTCTAT	0.388													26	53					0	0	0	0	A	33768373	A	A	33768373	2	1	141	1	0	0	0	0	0	0	0	1	14800	932	33	2		2	SLFN13	17	33768373	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1078230	33768373	47426837	477	25752											
TOP2A	7153	broad.mit.edu	37	chr17	38564238	38564238	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcttatgagaagcttctCgaacattgagtatttttcct	9	16	7	9	1	1	2	0	2	1	1	3	4	2	2	2	0	3	3	2	0	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:38564238C>A	uc002huq.2	-	12	1607	c.1481G>T	c.(1480-1482)CGA>CTA	p.R494L	TOP2A_uc002hur.1_Missense_Mutation_p.R135L	NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	494					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	AGAAGCTTCTCGAACATTGAG	0.373													36	68					1.59932e-28	2.4072e-28	1	0	A	38564238	A	A	38564238	3	1	141	1	0	0	0	0	1	0	0	0	16432	884	31	3	3210	3	TOP2A	17	38564238	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4795865	38564238	42630972	478	25753											
KRT10	3858	broad.mit.edu	37	chr17	38975866	38975866	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtattcagtattctggcactCggtttcagctcgaatctgtt	7	16	9	9	2	4	0	2	0	2	0	6	1	4	0	0	2	1	6	0	2	3	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:38975866C>G	uc002hvi.2	-	6	1302	c.1276G>C	c.(1276-1278)GAG>CAG	p.E426Q	KRT10_uc010cxd.2_RNA|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	426	Rod.|Gly-rich.|Coil 2.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				TTCTGGCACTCGGTTTCAGCT	0.483													6	135					0	0	0	0	G	38975866	G	G	38975866	3	3	141	1	0	0	0	0	1	0	0	0	8487	893	31	3	490	3	KRT10	17	38975866	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	411628	38975866	42219344	479	25754											
CNTNAP1	8506	broad.mit.edu	37	chr17	40847817	40847817	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccttcagcttcagcaccAgctccgcccctgctgtcctg	4	11	7	19	1	3	0	2	0	1	0	6	0	5	0	6	0	4	4	6	0	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:40847817A>T	uc002iay.2	+	19	3487	c.3271A>T	c.(3271-3273)AGC>TGC	p.S1091C	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	1091	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		CTTCAGCACCAGCTCCGCCCC	0.617													34	47					0	0	0	0	T	40847817	T	T	40847817	3	4	141	1	0	0	0	0	1	0	0	0	3661	188	7	5	3345	5	CNTNAP1	17	40847817	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	1871951	40847817	40347393	480	25755											
G6PC	2538	broad.mit.edu	37	chr17	41052904	41052904	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggaaatgaggatggaggaagGaatgaatgttctccatgact	14	9	14	4	0	1	3	0	3	1	0	2	8	1	8	1	5	0	1	1	5	4	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:41052904G>A	uc002icb.1	+	1	90	c.11G>A	c.(10-12)GGA>GAA	p.G4E	LOC388387_uc002ibz.2_5'Flank|LOC388387_uc002iby.2_5'Flank|LOC388387_uc002ica.2_5'Flank|LOC388387_uc010whe.1_5'Flank|G6PC_uc010whf.1_Missense_Mutation_p.G6E	NM_000151	NP_000142	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	4	Lumenal (Potential).				gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		ATGGAGGAAGGAATGAATGTT	0.498									Glycogen_Storage_Disease_type_Ia				10	46					0	0	0	0	A	41052904	A	A	41052904	3	1	141	1	0	0	0	0	1	0	0	0	6177	1174	41	2	13	2	G6PC	17	41052904	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	205087	41052904	40142306	481	25756											
CACNA1G	8913	broad.mit.edu	37	chr17	48676874	48676874	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccggaacagcctcggccGtgcacccagcctgaagcgga	9	3	13	16	4	0	1	0	1	0	0	1	3	0	3	5	3	6	1	5	3	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:48676874G>T	uc002irk.1	+	17	3716	c.3344G>T	c.(3343-3345)CGT>CTT	p.R1115L	CACNA1G_uc002iri.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irj.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irl.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irm.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irn.1_Missense_Mutation_p.R1092L|CACNA1G_uc002iro.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irp.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irq.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irr.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irs.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irt.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irv.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irw.1_Missense_Mutation_p.R1092L|CACNA1G_uc002iru.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irx.1_Missense_Mutation_p.R1028L|CACNA1G_uc002iry.1_Missense_Mutation_p.R1028L|CACNA1G_uc002irz.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isa.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isb.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isc.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isd.1_Missense_Mutation_p.R1028L|CACNA1G_uc002ise.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isf.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isg.1_Missense_Mutation_p.R1028L|CACNA1G_uc002ish.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isi.1_Missense_Mutation_p.R1005L|CACNA1G_uc002isj.2_5'UTR	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1115	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AGCCTCGGCCGTGCACCCAGC	0.677													10	9					4.68919e-08	5.42998e-08	1	0	T	48676874	T	T	48676874	3	4	141	1	0	0	0	0	1	0	0	0	2556	1145	40	3	3410	3	CACNA1G	17	48676874	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	7623970	48676874	32518336	482	25757											
C17orf47	284083	broad.mit.edu	37	chr17	56620307	56620309	+	Missense_Mutation	TNP	GGC	TTT	TTT																															acctaggtaaggaccgaggaGgcaagggcctaggggtcagt																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:56620307_56620309GGC>TTT	uc002iwq.1	-	1	1375_1377	c.1239_1241GCC>AAA	c.(1237-1242)TTGCCT>TTAAAT	p.P414N	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	414										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGACCGAGGAGGCAAGGGCCTAG	0.527													24	79					0	0	0	0	TTT	56620309	TTT	TTT	56620307	3	4	141	1	0	0	0	0	1	0	0	0	1865	1000	35	4	479	4	C17orf47	17	56620307	Missense_Mutation	TNP	GGC	TCGA-CR-7370-01A-11D-2129-08	7943433	56620307	24574903	483	25758											
USP32	84669	broad.mit.edu	37	chr17	58258936	58258936	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatatctgcccagccccatTttctttgctggcatccaagt	8	13	6	14	0	2	0	0	0	2	0	3	0	3	0	4	1	3	2	4	1	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:58258936T>A	uc002iyo.1	-	32	4583	c.4297A>T	c.(4297-4299)AAT>TAT	p.N1433Y	USP32_uc002iyn.1_Missense_Mutation_p.N1103Y	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1433					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			CCAGCCCCATTTTCTTTGCTG	0.552													17	55					0	0	0	0	A	58258936	A	A	58258936	3	1	141	1	0	0	0	0	1	0	0	0	17131	1841	64	5	529	5	USP32	17	58258936	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	1638629	58258936	22936274	484	25759											
ACE	1636	broad.mit.edu	37	chr17	61557822	61557822	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccatgccttcgtccgccgCgcactgcatcgccgatacgg	5	8	10	18	7	0	0	0	0	0	0	4	1	2	0	5	1	3	2	5	1	1	2	rs4302	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:61557822C>T	uc002jau.1	+	5	802	c.780C>T	c.(778-780)CGC>CGT	p.R260R	ACE_uc010wpi.1_Silent_p.R260R|ACE_uc010ddu.1_Silent_p.R77R	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	260	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TCGTCCGCCGCGCACTGCATC	0.607													31	65					0	0	0	0	T	61557822	T	T	61557822	2	4	141	1	0	0	0	0	0	0	0	1	136	755	27	1		1	ACE	17	61557822	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3298886	61557822	19637388	485	25760											
TEX2	55852	broad.mit.edu	37	chr17	62291328	62291328	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcagggccggcggggtCatggccaacttggggttcaa	7	6	18	10	2	2	0	2	0	0	0	2	0	2	0	2	8	2	3	2	8	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:62291328C>A	uc002jec.2	-	2	423	c.250G>T	c.(250-252)GAC>TAC	p.D84Y	TEX2_uc002jed.2_Missense_Mutation_p.D84Y|TEX2_uc002jee.2_Missense_Mutation_p.D84Y	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	84					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CCGGCGGGGTCATGGCCAACT	0.562													97	160					1.26289e-39	1.96123e-39	1	0	A	62291328	A	A	62291328	3	1	141	1	0	0	0	0	1	0	0	0	15847	826	29	2	3198	2	TEX2	17	62291328	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	733506	62291328	18903882	486	25761											
PITPNC1	26207	broad.mit.edu	37	chr17	65628289	65628289	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaagccaaagacgtggagAgagaagtttgctttattgat	14	11	12	4	1	0	5	0	2	0	3	0	7	0	5	1	1	2	2	1	1	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:65628289A>T	uc002jgc.2	+	6	744	c.397A>T	c.(397-399)AGA>TGA	p.R133*	PITPNC1_uc002jgb.2_Nonsense_Mutation_p.R133*	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	133					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			AGACGTGGAGAGAGAAGTTTG	0.428													22	32					0	0	0	0	T	65628289	T	T	65628289	4	4	141	1	0	0	0	0	0	1	0	0	12004	296	11	5	419	5	PITPNC1	17	65628289	Nonsense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	3336961	65628289	15566921	487	25762											
NOL11	25926	broad.mit.edu	37	chr17	65722658	65722658	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagagcttagttaaatcactGctgctcaaggctgttgtatc	10	13	9	9	0	2	1	2	0	0	1	3	1	2	1	0	1	3	7	0	1	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:65722658G>A	uc002jgd.1	+	7	750	c.747G>A	c.(745-747)CTG>CTA	p.L249L	NOL11_uc010wql.1_Silent_p.L67L|NOL11_uc010deu.1_5'UTR	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	249						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTAAATCACTGCTGCTCAAGG	0.458													33	42					0	0	0	0	A	65722658	A	A	65722658	2	1	141	1	0	0	0	0	0	0	0	1	10575	1306	46	4		4	NOL11	17	65722658	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	94369	65722658	15472552	488	25763											
ENOSF1	55556	broad.mit.edu	37	chr18	677394	677394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtagtcaaatataatcaggtGctgcaccagttcacagaggc	13	9	10	9	0	3	1	3	0	0	1	3	1	3	1	1	2	2	4	1	2	4	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:677394G>A	uc002kku.3	-	14	1174	c.1099C>T	c.(1099-1101)CAC>TAC	p.H367Y	ENOSF1_uc002kkt.3_Missense_Mutation_p.H285Y|ENOSF1_uc010dke.2_RNA|ENOSF1_uc010dkf.2_Missense_Mutation_p.H374Y|ENOSF1_uc002kkv.3_Missense_Mutation_p.H354Y|ENOSF1_uc002kkw.3_Missense_Mutation_p.H186Y|ENOSF1_uc002kkx.3_Missense_Mutation_p.H291Y	NM_017512	NP_059982	Q7L5Y1	ENOF1_HUMAN	enolase superfamily 1 isoform rTS beta	367					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			ovary(1)	1						ATAATCAGGTGCTGCACCAGT	0.433													6	129					0	0	0	0	A	677394	A	A	677394	3	1	141	1	0	0	0	0	1	0	0	0	5149	1319	46	4	244	4	ENOSF1	18	677394	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08		677394	77399854	489	25764											
EPB41L3	23136	broad.mit.edu	37	chr18	5397201	5397201	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccttcctctttagccccCtccgtcaaggcagagccctc	5	10	6	20	1	2	1	1	0	1	1	6	1	5	1	7	1	2	1	7	1	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:5397201C>A	uc002kmt.1	-	18	2783	c.2697G>T	c.(2695-2697)GAG>GAT	p.E899D	EPB41L3_uc010wzh.1_Missense_Mutation_p.E730D|EPB41L3_uc002kmu.1_Missense_Mutation_p.E677D|EPB41L3_uc010dkq.1_Missense_Mutation_p.E568D|EPB41L3_uc002kms.1_Missense_Mutation_p.E134D|EPB41L3_uc010wze.1_Missense_Mutation_p.E204D|EPB41L3_uc010wzf.1_Missense_Mutation_p.E196D|EPB41L3_uc010wzg.1_Missense_Mutation_p.E171D|EPB41L3_uc010dkr.2_Missense_Mutation_p.E291D	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	899	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CTTTAGCCCCCTCCGTCAAGG	0.602													175	53					2.60769e-80	4.17344e-80	1	0	A	5397201	A	A	5397201	3	1	141	1	0	0	0	0	1	0	0	0	5178	680	24	4	586	4	EPB41L3	18	5397201	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4719807	5397201	72680047	490	25765											
PTPRM	5797	broad.mit.edu	37	chr18	7888335	7888335	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacacgtacatggaacagggCagaactggccattagtactt	14	8	10	9	1	0	1	0	0	0	1	0	2	0	2	1	3	5	3	1	3	6	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:7888335C>A	uc002knn.3	+	3	931	c.428C>A	c.(427-429)GCA>GAA	p.A143E	PTPRM_uc010dkv.2_Missense_Mutation_p.A143E	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	143	MAM.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				TGGAACAGGGCAGAACTGGCC	0.403													7	145					5.4927e-09	6.48334e-09	1	0	A	7888335	A	A	7888335	3	1	141	1	0	0	0	0	1	0	0	0	12871	710	25	4	438	4	PTPRM	18	7888335	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2491134	7888335	70188913	491	25766											
PTPRM	5797	broad.mit.edu	37	chr18	8113617	8113617	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagtactactttgctgcaGaatttcctgcagacagcctc	10	11	7	13	0	0	2	0	0	0	2	2	2	1	2	2	0	6	4	2	0	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:8113617G>T	uc002knn.3	+	12	2493	c.1990G>T	c.(1990-1992)GAA>TAA	p.E664*	PTPRM_uc010dkv.2_Nonsense_Mutation_p.E664*|PTPRM_uc010wzl.1_Nonsense_Mutation_p.E451*	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	664	Fibronectin type-III 4.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CTTTGCTGCAGAATTTCCTGC	0.428													125	37					2.60151e-83	4.17266e-83	1	0	T	8113617	T	T	8113617	4	4	141	1	0	0	0	0	0	1	0	0	12871	943	33	2	2036	2	PTPRM	18	8113617	Nonsense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	225282	8113617	69963631	492	25767											
KIAA0802	23255	broad.mit.edu	37	chr18	8786039	8786039	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgcaccgccgcgcagacGgggacaccgggagccacggg	8	1	17	15	6	0	1	0	0	0	1	0	3	0	3	4	4	3	3	4	4	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:8786039G>A	uc002knr.2	+	7	1979	c.1837G>A	c.(1837-1839)GGG>AGG	p.G613R	KIAA0802_uc002knq.2_Missense_Mutation_p.G613R|KIAA0802_uc010dkw.1_Missense_Mutation_p.G451R	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	964											0						CCGCGCAGACGGGGACACCGG	0.726													17	3					0	0	0	0	A	8786039	A	A	8786039	3	1	141	1	0	0	0	0	1	0	0	0	8233	1116	39	1	1855	1	KIAA0802	18	8786039	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	672422	8786039	69291209	493	25768											
GNAL	2774	broad.mit.edu	37	chr18	11868555	11868555	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccaagatgtcacagctatCatttacgtcgcagcctgcag	11	9	8	13	2	2	1	2	0	0	1	3	1	2	1	2	0	4	3	2	0	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:11868555C>T	uc010dkz.2	+	10	939	c.693C>T	c.(691-693)ATC>ATT	p.I231I	GNAL_uc002kqc.2_Silent_p.I308I|GNAL_uc002kqd.2_Silent_p.I231I|GNAL_uc010wzt.1_Silent_p.I24I	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	231					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						TCACAGCTATCATTTACGTCG	0.463													11	223					0	0	0	0	T	11868555	T	T	11868555	2	4	141	1	0	0	0	0	0	0	0	1	6544	816	29	2		2	GNAL	18	11868555	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3082516	11868555	66208693	494	25769											
POTEC	388468	broad.mit.edu	37	chr18	14542920	14542920	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcccacgttgctcgtgcCgctccccctgcagcagggga	5	7	13	16	3	0	0	0	0	0	0	2	1	1	1	4	2	5	5	4	2	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:14542920C>T	uc010dln.2	-	1	680	c.226G>A	c.(226-228)GGC>AGC	p.G76S	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	76										skin(3)	3						TTGCTCGTGCCGCTCCCCCTG	0.572													14	402					0	0	0	0	T	14542920	T	T	14542920	3	4	141	1	0	0	0	0	1	0	0	0	12317	652	23	1	1446	1	POTEC	18	14542920	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2674365	14542920	63534328	495	25770											
KIAA1632	57724	broad.mit.edu	37	chr18	43492360	43492360	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagagcctggtgggcccagCgataaatcagcagcctctgg	9	6	13	13	1	2	1	1	0	1	1	2	2	2	1	4	3	4	1	4	3	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:43492360C>A	uc002lbm.2	-	22	3978	c.3878G>T	c.(3877-3879)CGC>CTC	p.R1293L	KIAA1632_uc002lbo.1_Missense_Mutation_p.R1293L|KIAA1632_uc010xcq.1_5'UTR|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.R168L	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1293					autophagy						0						GTGGGCCCAGCGATAAATCAG	0.537													6	75					1.06961e-07	1.22696e-07	1	0	A	43492360	A	A	43492360	3	1	141	1	0	0	0	0	1	0	0	0	8288	768	27	3	3953	3	KIAA1632	18	43492360	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	28949440	43492360	34584888	496	25771											
DCC	1630	broad.mit.edu	37	chr18	50866223	50866223	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atggcgttgggagcccttacGctgagacagtgcgtgtggac	7	9	16	9	3	0	1	0	1	0	1	0	4	0	3	1	3	3	2	1	3	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:50866223G>A	uc002lfe.1	+	15	2892	c.2305G>A	c.(2305-2307)GCT>ACT	p.A769T	DCC_uc010xdr.1_Missense_Mutation_p.A617T|DCC_uc010dpf.1_Missense_Mutation_p.A424T	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	769	Extracellular (Potential).|Fibronectin type-III 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GAGCCCTTACGCTGAGACAGT	0.448													10	31					0	0	0	0	A	50866223	A	A	50866223	3	1	141	1	0	0	0	0	1	0	0	0	4299	1087	38	1	2363	1	DCC	18	50866223	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	7373863	50866223	27211025	497	25772											
CDH7	1005	broad.mit.edu	37	chr18	63547683	63547683	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agaagacggaaaaaagagccCcttatttttgacgaagaaag	18	7	10	6	2	0	5	0	1	0	4	0	7	0	6	2	1	1	0	2	1	7	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:63547683C>A	uc002ljz.2	+	12	2236	c.1911C>A	c.(1909-1911)CCC>CCA	p.P637P	CDH7_uc002lkb.2_Silent_p.P637P	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	637	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				AAAAAGAGCCCCTTATTTTTG	0.458													10	18					0.000442599	0.000467472	1	0	A	63547683	A	A	63547683	2	1	141	1	0	0	0	0	0	0	0	1	3130	610	22	4		4	CDH7	18	63547683	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	12681460	63547683	14529565	498	25773											
TSHZ1	10194	broad.mit.edu	37	chr18	72997606	72997606	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcgcccttcagtgagagcAgcgaccagctagcccatttc	8	8	11	14	2	1	1	1	1	0	1	3	3	1	1	3	1	4	2	3	1	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:72997606A>T	uc002lly.2	+	2	672	c.109A>T	c.(109-111)AGC>TGC	p.S37C		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	82	Ser-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CAGTGAGAGCAGCGACCAGCT	0.597													9	10					0	0	0	0	T	72997606	T	T	72997606	3	4	141	1	0	0	0	0	1	0	0	0	16690	188	7	5	111	5	TSHZ1	18	72997606	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	9449923	72997606	5079642	499	25774											
ANKRD24	170961	broad.mit.edu	37	chr19	4216937	4216937	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggagctgaggccacaggaGccaaggtcacagaaacaaaa	16	2	13	10	1	1	2	1	1	0	1	1	4	1	4	2	4	3	1	2	4	4	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:4216937G>T	uc010dtt.1	+	18	2056	c.1780G>T	c.(1780-1782)GCC>TCC	p.A594S	ANKRD24_uc002lzs.2_Missense_Mutation_p.A565S|ANKRD24_uc002lzt.2_Missense_Mutation_p.A566S	NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	594											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		GGCCACAGGAGCCAAGGTCAC	0.562													3	11					0.004672	0.00482335	1	0	T	4216937	T	T	4216937	3	4	141	1	0	0	0	0	1	0	0	0	653	971	34	4	1846	4	ANKRD24	19	4216937	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08		4216937	54912046	500	25775											
MUC16	94025	broad.mit.edu	37	chr19	9074423	9074423	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaaagtggcttgtgtcttGgtgacatgagtagtagcatc	10	12	14	5	0	1	3	0	2	1	1	2	4	1	3	0	2	1	4	0	2	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:9074423G>T	uc002mkp.2	-	3	13227	c.13023C>A	c.(13021-13023)ACC>ACA	p.T4341T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4343	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTTGTGTCTTGGTGACATGAG	0.483													4	26					1.06961e-07	1.22696e-07	1	0	T	9074423	T	T	9074423	2	4	141	1	0	0	0	0	0	0	0	1	10026	1335	47	4		4	MUC16	19	9074423	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4857486	9074423	50054560	501	25776											
CDC37	11140	broad.mit.edu	37	chr19	10505718	10505718	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttaatcttagtgaagaactgCcggaagcaggcccgggggtc	10	8	14	9	2	1	2	0	1	1	1	2	3	1	3	2	4	3	1	2	4	5	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:10505718C>A	uc002mof.1	-	5	821	c.705G>T	c.(703-705)CGG>CGT	p.R235R	CDC37_uc002moe.1_Silent_p.R190R|CDC37_uc010dxf.1_Silent_p.R72R|CDC37_uc002mog.1_Intron|CDC37_uc002moh.2_Silent_p.R235R	NM_007065	NP_008996	Q16543	CDC37_HUMAN	cell division cycle 37 protein	235					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		TGAAGAACTGCCGGAAGCAGG	0.587													78	22					4.97629e-18	6.79258e-18	1	0	A	10505718	A	A	10505718	2	1	141	1	0	0	0	0	0	0	0	1	3083	726	26	4		4	CDC37	19	10505718	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1431295	10505718	48623265	502	25777											
ZNF878	729747	broad.mit.edu	37	chr19	12154763	12154763	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagaaatgaaggctttccCacactgtttacatttatagg	13	12	9	7	0	0	2	0	1	0	1	1	3	1	3	1	3	1	2	1	3	6	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:12154763C>G	uc002mta.1	-	5	1594	c.1594G>C	c.(1594-1596)GGG>CGG	p.G532R		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	485	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AAGGCTTTCCCACACTGTTTA	0.383													49	13					0	0	0	0	G	12154763	G	G	12154763	3	3	141	1	0	0	0	0	1	0	0	0	18263	594	21	4	146	4	ZNF878	19	12154763	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1649045	12154763	46974220	503	25778											
ZNF709	163051	broad.mit.edu	37	chr19	12577309	12577309	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgatttttgtgatcttcaAtgttcttctcctcccagttt	5	20	5	11	0	4	2	1	2	3	0	6	2	5	2	3	0	0	2	3	0	1	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:12577309A>C	uc002mtv.3	-	3	316	c.155T>G	c.(154-156)ATT>AGT	p.I52S	ZNF709_uc002mtw.3_Missense_Mutation_p.I20S|ZNF709_uc002mtx.3_Missense_Mutation_p.I52S	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTGATCTTCAATGTTCTTCTC	0.338													7	113					0	0	0	0	C	12577309	C	C	12577309	3	2	141	1	0	0	0	0	1	0	0	0	18180	101	4	5	1778	5	ZNF709	19	12577309	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	422546	12577309	46551674	504	25779											
WIZ	58525	broad.mit.edu	37	chr19	15537872	15537872	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agttccccatgaagggccccCggcagcatctcccgcttgat	7	8	10	16	2	1	2	0	2	1	0	3	2	2	2	5	2	1	4	5	2	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:15537872C>A	uc002nbc.2	-	4	1547	c.1524G>T	c.(1522-1524)CCG>CCT	p.P508P	WIZ_uc002nba.3_Silent_p.P375P|WIZ_uc002nbb.3_Silent_p.P334P	NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	1191						nucleus	zinc ion binding				0						GAAGGGCCCCCGGCAGCATCT	0.607													75	22					5.02462e-34	7.68904e-34	1	0	A	15537872	A	A	15537872	2	1	141	1	0	0	0	0	0	0	0	1	17443	639	23	3		3	WIZ	19	15537872	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2960563	15537872	43591111	505	25780											
PIK3R2	5296	broad.mit.edu	37	chr19	18271316	18271316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acttgcccgagcagttctccCcacctgatgtggctccccct	5	10	8	18	1	1	1	0	1	1	0	3	2	2	1	6	1	2	3	6	1	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:18271316C>T	uc002nia.1	+	3	870	c.358C>T	c.(358-360)CCA>TCA	p.P120S	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	120	Rho-GAP.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						GCAGTTCTCCCCACCTGATGT	0.577													29	34					0	0	0	0	T	18271316	T	T	18271316	3	4	141	1	0	0	0	0	1	0	0	0	11974	623	22	4	364	4	PIK3R2	19	18271316	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2733444	18271316	40857667	506	25781											
ZNF737	100129842	broad.mit.edu	37	chr19	20727787	20727787	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtagtaagggaagaggagtActtaaaggcttcgccacatt	13	10	12	6	1	0	1	0	0	0	1	1	3	0	3	1	3	1	4	1	3	6	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:20727787A>G	uc002npa.2	-	4	1402	c.1222T>C	c.(1222-1224)TAC>CAC	p.Y408H		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	408					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GAAGAGGAGTACTTAAAGGCT	0.428													21	43					0	0	0	0	G	20727787	G	G	20727787	3	3	141	1	0	0	0	0	1	0	0	0	18193	391	14	5	392	5	ZNF737	19	20727787	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	2456471	20727787	38401196	507	25782											
DPY19L3	147991	broad.mit.edu	37	chr19	32954307	32954307	+	Frame_Shift_Del	DEL	A	-	-																															acaatccgtgggtaaaatggAaaaaggcacagttgacctga																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:32954307delA	uc002ntg.2	+	13	1534	c.1358delA	c.(1357-1359)GAAfs	p.E453fs	DPY19L3_uc002nth.1_Frame_Shift_Del_p.E453fs|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	453						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					GGTAAAATGGAAAAAGGCACA	0.333													---	---	---								-	32954307	-	-	32954307	7	5	141	1	0	1	0	1	0	0	0	0	4764	246	9	0	1404	0	DPY19L3	19	32954307	Frame_Shift_Del	DEL	A	TCGA-CR-7370-01A-11D-2129-08	12226520	32954307	26174676	508	25783											
MLL4	9757	broad.mit.edu	37	chr19	36212275	36212275	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcttggggctcctgaaGcccctgagccagagcctcct	5	9	10	17	0	1	3	0	2	1	1	4	3	4	3	7	2	3	1	7	2	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:36212275G>A	uc010eei.2	+	3	2026	c.2026G>A	c.(2026-2028)GCC>ACC	p.A676T		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	676	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGCTCCTGAAGCCCCTGAGCC	0.642													7	7					0	0	0	0	A	36212275	A	A	36212275	3	1	141	1	0	0	0	0	1	0	0	0	9676	971	34	4	2036	4	MLL4	19	36212275	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3257968	36212275	22916708	509	25784											
ZNF568	374900	broad.mit.edu	37	chr19	37440567	37440567	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagttcagacattgttacttCaagacaaagcttctatgact	13	13	7	8	0	3	3	2	1	1	2	3	4	3	3	0	0	2	3	0	0	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:37440567C>A	uc002ofc.2	+	7	1027	c.512C>A	c.(511-513)TCA>TAA	p.S171*	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Nonsense_Mutation_p.S95*|ZNF568_uc010efe.2_Nonsense_Mutation_p.S95*|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTGTTACTTCAAGACAAAGC	0.338													8	93					0.000157383	0.000167921	1	0	A	37440567	A	A	37440567	4	1	141	1	0	0	0	0	0	1	0	0	18066	838	29	2	530	2	ZNF568	19	37440567	Nonsense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1228292	37440567	21688416	510	25785											
GGN	199720	broad.mit.edu	37	chr19	38876144	38876144	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggacaggagttaagcacctgGaagggcagccagtggcgcgc	10	4	17	10	2	0	0	0	0	0	0	0	3	0	3	2	5	2	3	2	5	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:38876144G>T	uc002oij.1	-	3	1893	c.1758C>A	c.(1756-1758)TTC>TTA	p.F586L	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Intron	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	586	Interactions with ZNF403/GGNBP2 and OAZ3 (By similarity).				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TAAGCACCTGGAAGGGCAGCC	0.667													15	27					8.60227e-14	1.11799e-13	1	0	T	38876144	T	T	38876144	3	4	141	1	0	0	0	0	1	0	0	0	6395	1165	41	2	208	2	GGN	19	38876144	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1435577	38876144	20252839	511	25786											
FAM98C	147965	broad.mit.edu	37	chr19	38899416	38899416	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgggcaacgttccagaccGggggggccgcccaaatgagc	9	5	15	12	3	0	2	0	1	0	1	1	2	1	2	4	4	2	2	4	4	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:38899416G>T	uc002oin.1	+	8	963	c.944G>T	c.(943-945)CGG>CTG	p.R315L	FAM98C_uc002oio.1_Missense_Mutation_p.R233L|FAM98C_uc010xtz.1_Silent_p.P181P	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	315										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GTTCCAGACCGGGGGGGCCGC	0.562													24	69					9.86323e-18	1.34133e-17	1	0	T	38899416	T	T	38899416	3	4	141	1	0	0	0	0	1	0	0	0	5690	1116	39	3	974	3	FAM98C	19	38899416	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	23272	38899416	20229567	512	25787											
NCCRP1	342897	broad.mit.edu	37	chr19	39691333	39691333	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggccaagaaccgcatggaGcctggtgggctgcggcggac	9	4	17	11	3	0	1	0	0	0	1	0	3	0	3	3	6	3	2	3	6	3	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:39691333G>C	uc002okq.1	+	6	784	c.765G>C	c.(763-765)GAG>GAC	p.E255D		NM_001001414	NP_001001414	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1	255	FBA.				protein catabolic process					ovary(1)	1						ACCGCATGGAGCCTGGTGGGC	0.632													121	196					0	0	0	0	C	39691333	C	C	39691333	3	2	141	1	0	0	0	0	1	0	0	0	10267	962	34	4	787	4	NCCRP1	19	39691333	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	791917	39691333	19437650	513	25788											
PRX	57716	broad.mit.edu	37	chr19	40909731	40909731	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accccggtctgcgcctccgtCtccacgataatttccaccaa	8	9	6	18	4	2	0	0	0	2	0	5	1	4	0	7	1	1	0	7	1	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:40909731C>G	uc002onr.2	-	5	335	c.66G>C	c.(64-66)GAG>GAC	p.E22D	PRX_uc002onq.2_5'UTR|PRX_uc002ons.2_Missense_Mutation_p.E22D	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	22	PDZ.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCGCCTCCGTCTCCACGATAA	0.692													6	15					0	0	0	0	G	40909731	G	G	40909731	3	3	141	1	0	0	0	0	1	0	0	0	12704	912	32	2	4394	2	PRX	19	40909731	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1218398	40909731	18219252	514	25789											
TGFB1	7040	broad.mit.edu	37	chr19	41854358	41854358	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgcttgaacttgtcatagaTttctagcagggagaaatgaa	13	12	10	6	0	2	4	1	2	1	2	2	5	2	4	0	1	3	2	0	1	5	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:41854358T>C	uc002oqh.1	-	2	1225	c.358A>G	c.(358-360)ATC>GTC	p.I120V	CYP2F1_uc010xvw.1_Intron|TMEM91_uc002oqi.2_5'Flank	NM_000660	NP_000651	P01137	TGFB1_HUMAN	transforming growth factor, beta 1 precursor	120					active induction of host immune response by virus|ATP biosynthetic process|cell cycle arrest|cell growth|cell-cell junction organization|chondrocyte differentiation|connective tissue replacement involved in inflammatory response wound healing|epidermal growth factor receptor signaling pathway|evasion of host defenses by virus|hemopoietic progenitor cell differentiation|induction of apoptosis|lymph node development|mitotic cell cycle G1/S transition checkpoint|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of cell-cell adhesion|negative regulation of DNA replication|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|negative regulation of macrophage cytokine production|negative regulation of mitotic cell cycle|negative regulation of protein phosphorylation|ossification involved in bone remodeling|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of collagen biosynthetic process|positive regulation of epithelial to mesenchymal transition|positive regulation of fibroblast migration|positive regulation of interleukin-17 production|positive regulation of isotype switching to IgA isotypes|positive regulation of MAP kinase activity|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein dephosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|protein export from nucleus|protein import into nucleus, translocation|receptor catabolic process|regulation of DNA binding|regulation of striated muscle tissue development|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|response to estradiol stimulus|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway|viral infectious cycle	extracellular space|Golgi lumen|nucleus|platelet alpha granule lumen|proteinaceous extracellular matrix	growth factor activity|type II transforming growth factor beta receptor binding				0					Hyaluronidase(DB00070)	TTGTCATAGATTTCTAGCAGG	0.527													45	68					0	0	0	0	C	41854358	C	C	41854358	3	2	141	1	0	0	0	0	1	0	0	0	15882	1493	52	5	838	5	TGFB1	19	41854358	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	944627	41854358	17274625	515	25790											
CEACAM7	1087	broad.mit.edu	37	chr19	42187790	42187790	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttcacattcatagggtcctAtgtcattctttgtggcgctg	6	17	9	9	1	4	0	3	0	1	0	5	0	5	0	1	2	0	1	1	2	2	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:42187790A>T	uc002ori.1	-	3	634	c.632T>A	c.(631-633)ATA>AAA	p.I211K	CEACAM7_uc010ehx.2_Missense_Mutation_p.I211K|CEACAM7_uc010ehy.1_Intron	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	211	Ig-like C2-type.					anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		ATAGGGTCCTATGTCATTCTT	0.542													93	131					0	0	0	0	T	42187790	T	T	42187790	3	4	141	1	0	0	0	0	1	0	0	0	3212	449	16	5	173	5	CEACAM7	19	42187790	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	333432	42187790	16941193	516	25791											
CEACAM5	1048	broad.mit.edu	37	chr19	42224051	42224051	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaatgtcacaagaaatgaCgcaagagcctatgtatgtgg	14	10	10	7	1	2	3	2	1	0	2	2	3	2	3	1	1	1	2	1	1	6	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:42224051C>T	uc002ork.2	+	7	1816	c.1695C>T	c.(1693-1695)GAC>GAT	p.D565D	CEACAM5_uc002orj.1_Silent_p.D564D|CEACAM5_uc002orl.2_Silent_p.D565D	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	565	Ig-like 6.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CAAGAAATGACGCAAGAGCCT	0.517													99	125					0	0	0	0	T	42224051	T	T	42224051	2	4	141	1	0	0	0	0	0	0	0	1	3210	535	19	1		1	CEACAM5	19	42224051	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	36261	42224051	16904932	517	25792											
RELB	5971	broad.mit.edu	37	chr19	45540703	45540703	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgctgccagaccctgaCttcttctctggcaccgtgtc	4	11	9	17	1	2	2	0	1	2	1	4	2	2	2	4	1	2	2	4	1	0	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:45540703C>A	uc002paj.1	+	13	1521	c.1395C>A	c.(1393-1395)GAC>GAA	p.D465E	SFRS16_uc002pak.2_5'Flank|SFRS16_uc002pal.2_5'Flank|SFRS16_uc010xxh.1_5'Flank|SFRS16_uc002pam.2_5'Flank|SFRS16_uc002pan.1_5'Flank	NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	465						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		CAGACCCTGACTTCTTCTCTG	0.632													41	193					5.44703e-19	7.56188e-19	1	0	A	45540703	A	A	45540703	3	1	141	1	0	0	0	0	1	0	0	0	13282	564	20	4	1433	4	RELB	19	45540703	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3316652	45540703	13588280	518	25793											
SFRS16	11129	broad.mit.edu	37	chr19	45570821	45570821	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagctgaccaggccggccGcgtcccctgctgtgggcgag	6	5	16	14	4	0	2	0	1	0	1	1	3	1	2	5	3	2	2	5	3	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:45570821G>T	uc002pak.2	+	14	1734	c.1636G>T	c.(1636-1638)GCG>TCG	p.A546S	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Missense_Mutation_p.A484S|SFRS16_uc002pam.2_Missense_Mutation_p.A546S	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	546	Arg-rich.				mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CAGGCCGGCCGCGTCCCCTGC	0.438													14	13					6.31663e-08	7.29148e-08	1	0	T	45570821	T	T	45570821	3	4	141	1	0	0	0	0	1	0	0	0	14237	1087	38	3	1686	3	SFRS16	19	45570821	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	30118	45570821	13558162	519	25794											
CCDC8	83987	broad.mit.edu	37	chr19	46914604	46914604	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctctccggcgcttgcaaaaCcacgaaaagcgtccaggggt	10	6	12	13	4	1	0	0	0	1	0	3	1	2	0	3	3	3	3	3	3	4	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:46914604C>T	uc002pep.2	-	1	2316	c.1464G>A	c.(1462-1464)TGG>TGA	p.W488*		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	488						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		GCTTGCAAAACCACGAAAAGC	0.622													37	57					0	0	0	0	T	46914604	T	T	46914604	4	4	141	1	0	0	0	0	0	1	0	0	2866	508	18	4	156	4	CCDC8	19	46914604	Nonsense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1343783	46914604	12214379	520	25795											
GYS1	2997	broad.mit.edu	37	chr19	49488819	49488819	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccctttccatgcagtatCggtggtagatctgcctctcc	5	12	9	15	2	2	1	0	0	2	1	5	1	3	1	5	2	2	3	5	2	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:49488819C>A	uc002plp.2	-	5	963	c.722G>T	c.(721-723)CGA>CTA	p.R241L	GYS1_uc010xzy.1_Intron|GYS1_uc010emm.2_Missense_Mutation_p.R177L|GYS1_uc010xzz.1_Missense_Mutation_p.R161L|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	241					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		CATGCAGTATCGGTGGTAGAT	0.522													26	56					4.87955e-14	6.3756e-14	1	0	A	49488819	A	A	49488819	3	1	141	1	0	0	0	0	1	0	0	0	6951	884	31	3	1539	3	GYS1	19	49488819	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2574215	49488819	9640164	521	25796											
PRR12	57479	broad.mit.edu	37	chr19	50123642	50123642	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggcgtctgctcaaaaccaGggcgatgcgggagatgtacc	9	7	15	10	3	2	1	1	0	1	1	2	3	2	1	2	3	4	2	2	3	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:50123642G>T	uc002poo.3	+	10	5531	c.5531G>T	c.(5530-5532)AGG>ATG	p.R1844M		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	1023							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CTCAAAACCAGGGCGATGCGG	0.507													3	16					0.004672	0.00482335	1	0	T	50123642	T	T	50123642	3	4	141	1	0	0	0	0	1	0	0	0	12646	1000	35	4	5569	4	PRR12	19	50123642	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	634823	50123642	9005341	522	25797											
CPT1C	126129	broad.mit.edu	37	chr19	50204810	50204810	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacttcgactggaccgcggtCctggcgcaggaattcctgag	7	8	14	12	4	0	1	0	1	0	0	3	5	2	3	3	4	0	1	3	4	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:50204810C>A	uc002ppj.2	+	6	817	c.612C>A	c.(610-612)GTC>GTA	p.V204V	CPT1C_uc002ppl.3_Silent_p.V170V|CPT1C_uc002ppi.2_Silent_p.V121V|CPT1C_uc002ppk.2_Silent_p.V204V|CPT1C_uc010eng.2_Silent_p.V204V|CPT1C_uc010enh.2_Silent_p.V204V|CPT1C_uc010ybc.1_Silent_p.V42V	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	204	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GGACCGCGGTCCTGGCGCAGG	0.577													27	31					2.12542e-12	2.71416e-12	1	0	A	50204810	A	A	50204810	2	1	141	1	0	0	0	0	0	0	0	1	3848	842	30	2		2	CPT1C	19	50204810	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	81168	50204810	8924173	523	25798											
AP2A1	160	broad.mit.edu	37	chr19	50305113	50305113	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccccagcagcaacgacatCaacgggggcatggagcccac	12	2	12	15	2	1	0	1	0	0	0	1	3	1	1	3	3	5	3	3	3	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:50305113C>T	uc002ppn.2	+	14	2131	c.1920C>T	c.(1918-1920)ATC>ATT	p.I640I	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Silent_p.I640I|AP2A1_uc002ppp.1_Missense_Mutation_p.S11L	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	640					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		GCAACGACATCAACGGGGGCA	0.716													6	4					0	0	0	0	T	50305113	T	T	50305113	2	4	141	1	0	0	0	0	0	0	0	1	739	816	29	2		2	AP2A1	19	50305113	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	100303	50305113	8823870	524	25799											
NUP62	23636	broad.mit.edu	37	chr19	50412135	50412135	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagggccaggtggagcggtCacggcagctgctgtattgct	6	8	16	11	2	1	0	1	0	0	0	1	1	1	1	2	5	4	5	2	5	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:50412135C>A	uc002pqx.2	-	2	1034	c.930G>T	c.(928-930)GTG>GTT	p.V310V	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Silent_p.V310V|NUP62_uc002pqz.2_Silent_p.V310V|NUP62_uc002pra.2_Silent_p.V310V|NUP62_uc002prb.2_Silent_p.V310V|NUP62_uc002prc.2_Intron	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	310	Ala-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GTGGAGCGGTCACGGCAGCTG	0.527													25	54					4.22769e-11	5.27922e-11	1	0	A	50412135	A	A	50412135	2	1	141	1	0	0	0	0	0	0	0	1	10822	813	29	2		2	NUP62	19	50412135	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	107022	50412135	8716848	525	25800											
SIGLEC9	27180	broad.mit.edu	37	chr19	51633327	51633327	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagtactcggagatcaagatCcacagatgagaaactgcaga	16	6	11	8	1	1	5	1	1	0	5	3	8	2	5	1	1	3	2	1	1	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:51633327C>A	uc002pvu.2	+	7	1450	c.1383C>A	c.(1381-1383)ATC>ATA	p.I461I	SIGLEC9_uc010yct.1_Intron	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	461	Cytoplasmic (Potential).				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		AGATCAAGATCCACAGATGAG	0.542													22	50					1.28384e-07	1.459e-07	1	0	A	51633327	A	A	51633327	2	1	141	1	0	0	0	0	0	0	0	1	14380	845	30	2		2	SIGLEC9	19	51633327	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1221192	51633327	7495656	526	25801											
SIGLEC14	100049587	broad.mit.edu	37	chr19	52149112	52149112	+	Frame_Shift_Del	DEL	C	-	-																															cctgacaggtgaggttggtgCcatggtcctcgggcctgggg																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:52149112delC	uc002pxf.3	-	3	743	c.623delG	c.(622-624)GGCfs	p.G208fs		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	208	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		GAGGTTGGTGCCATGGTCCTC	0.637													---	---	---								-	52149112	-	-	52149112	7	5	141	1	0	1	0	1	0	0	0	0	14374	739	26	0	587	0	SIGLEC14	19	52149112	Frame_Shift_Del	DEL	C	TCGA-CR-7370-01A-11D-2129-08	515785	52149112	6979871	527	25802											
ZNF649	65251	broad.mit.edu	37	chr19	52394076	52394076	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcaagacatatagaagtaaGctttctcacactcatcacag	15	9	7	10	0	3	2	3	0	1	2	4	2	3	2	0	1	1	3	0	1	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:52394076G>A	uc002pxy.2	-	5	1581	c.1313C>T	c.(1312-1314)GCT>GTT	p.A438V	ZNF577_uc010ydd.1_5'Flank|ZNF577_uc002pxx.3_5'Flank|ZNF577_uc002pxv.2_5'Flank|ZNF577_uc002pxw.2_5'Flank|ZNF577_uc010yde.1_5'Flank|ZNF577_uc010ydf.1_Intron	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	438	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		ATAGAAGTAAGCTTTCTCACA	0.448													99	195					0	0	0	0	A	52394076	A	A	52394076	3	1	141	1	0	0	0	0	1	0	0	0	18131	971	34	4	208	4	ZNF649	19	52394076	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	244964	52394076	6734907	528	25803											
ZNF615	284370	broad.mit.edu	37	chr19	52496176	52496176	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taacaaggatagacaagtgcGcaaaagctttcccacaatca	17	7	7	10	1	1	1	1	0	0	1	2	2	2	2	1	1	3	2	1	1	7	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:52496176G>A	uc002pye.1	-	6	2445	c.2153C>T	c.(2152-2154)GCG>GTG	p.A718V	ZNF615_uc002pyf.1_Missense_Mutation_p.A729V|ZNF615_uc002pyg.1_Missense_Mutation_p.A610V|ZNF615_uc002pyh.1_Missense_Mutation_p.A729V|ZNF615_uc010epi.1_Missense_Mutation_p.A725V|ZNF615_uc010ydg.1_Missense_Mutation_p.A723V	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	718	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		AGACAAGTGCGCAAAAGCTTT	0.438													76	103					0	0	0	0	A	52496176	A	A	52496176	3	1	141	1	0	0	0	0	1	0	0	0	18107	1087	38	1	46	1	ZNF615	19	52496176	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	102100	52496176	6632807	529	25804											
ZNF528	84436	broad.mit.edu	37	chr19	52919907	52919907	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaccatagaattcacattgGagagaaaccttacaaatgca	17	9	6	9	0	2	2	2	0	0	2	2	4	2	3	2	1	3	1	2	1	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:52919907G>T	uc002pzh.2	+	7	2228	c.1802G>T	c.(1801-1803)GGA>GTA	p.G601V	ZNF528_uc002pzi.2_Missense_Mutation_p.G368V	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	601					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		ATTCACATTGGAGAGAAACCT	0.418													34	62					9.80977e-26	1.45853e-25	1	0	T	52919907	T	T	52919907	3	4	141	1	0	0	0	0	1	0	0	0	18036	1174	41	2	1816	2	ZNF528	19	52919907	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	423731	52919907	6209076	530	25805											
ZNF83	55769	broad.mit.edu	37	chr19	53122257	53122257	+	5'Flank	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcctctgagcagggtccAggcatttccactcctcctga	7	10	10	14	0	1	2	0	2	1	0	6	3	6	2	5	2	1	2	5	2	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:53122257A>T	uc002pzu.3	-						ZNF83_uc002pzv.3_Intron|ZNF83_uc010eps.2_5'UTR|ZNF83_uc010ept.2_5'UTR|ZNF83_uc010epu.2_5'UTR|ZNF83_uc010epv.2_5'UTR|ZNF83_uc010epw.2_5'UTR|ZNF83_uc010epx.2_Intron|ZNF83_uc010epy.2_Intron|ZNF83_uc010epz.2_5'UTR|ZNF83_uc010eqb.1_Intron	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		AGCAGGGTCCAGGCATTTCCA	0.468													36	135					0	0	0	0	T	53122257	T	T	53122257	1	4	141	0	1	0	0	0	0	0	0	0	18250	203	7	5		5	ZNF83	19	53122257	5'Flank	SNP	A	TCGA-CR-7370-01A-11D-2129-08	202350	53122257	6006726	531	25806											
ZNF415	55786	broad.mit.edu	37	chr19	53612438	53612438	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaactctccgatgtagtgcaAggcatgagttgcgactgaaa	12	9	12	8	2	1	2	0	2	1	0	2	5	1	2	1	1	3	4	1	1	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:53612438A>G	uc002qax.2	-	7	1353	c.1004T>C	c.(1003-1005)CTT>CCT	p.L335P	ZNF415_uc002qat.2_Missense_Mutation_p.L299P|ZNF415_uc002qaw.2_Missense_Mutation_p.L287P|ZNF415_uc010yds.1_Missense_Mutation_p.L287P|ZNF415_uc010ydt.1_Missense_Mutation_p.L287P|ZNF415_uc002qau.2_Missense_Mutation_p.L274P|ZNF415_uc002qav.2_Missense_Mutation_p.L299P|ZNF415_uc002qba.2_Missense_Mutation_p.L57P|ZNF415_uc002qay.2_Missense_Mutation_p.L274P|ZNF415_uc002qaz.2_Missense_Mutation_p.L335P	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	335	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		ATGTAGTGCAAGGCATGAGTT	0.413													11	75					0	0	0	0	G	53612438	G	G	53612438	3	3	141	1	0	0	0	0	1	0	0	0	17959	72	3	5	811	5	ZNF415	19	53612438	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	490181	53612438	5516545	532	25807											
NLRP12	91662	broad.mit.edu	37	chr19	54297343	54297343	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaggttttgttactcgaagcGctgccaacctactgtgggtc	8	12	11	10	2	0	0	0	0	0	0	2	1	0	0	2	2	5	3	2	2	5	4	rs146786265	by1000genomes	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:54297343G>T	uc002qch.3	-	10	3366	c.3146C>A	c.(3145-3147)GCG>GAG	p.A1049E	NLRP12_uc010eqw.2_Missense_Mutation_p.A275E|NLRP12_uc002qci.3_Missense_Mutation_p.A992E|NLRP12_uc002qcj.3_Missense_Mutation_p.A1050E|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_3'UTR	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	1049	LRR 8.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TACTCGAAGCGCTGCCAACCT	0.463													21	54					5.35356e-11	6.63986e-11	1	0	T	54297343	T	T	54297343	3	4	141	1	0	0	0	0	1	0	0	0	10528	1087	38	3	43	3	NLRP12	19	54297343	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	684905	54297343	4831640	533	25808											
CACNG7	59284	broad.mit.edu	37	chr19	54418659	54418659	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttccccatggtcagcctCttcctcgtgttcacggcctt	3	13	7	18	2	3	0	2	0	1	0	6	0	5	0	6	2	1	1	6	2	0	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:54418659C>A	uc002qcr.1	+	3	339	c.324C>A	c.(322-324)CTC>CTA	p.L108L	CACNG7_uc010era.1_Silent_p.L108L	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	108	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		TGGTCAGCCTCTTCCTCGTGT	0.607													22	32					1.85244e-09	2.21869e-09	1	0	A	54418659	A	A	54418659	2	1	141	1	0	0	0	0	0	0	0	1	2574	900	32	2		2	CACNG7	19	54418659	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	121316	54418659	4710324	534	25809											
TMC4	147798	broad.mit.edu	37	chr19	54666867	54666867	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagaagagcaggaccaccaGggaggcgaggcgaagaaaca	17	0	16	8	2	0	3	0	0	0	3	0	8	0	5	2	4	2	1	2	4	3	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:54666867G>C	uc010erf.2	-	9	1453	c.1321C>G	c.(1321-1323)CTG>GTG	p.L441V	TMC4_uc002qdn.2_Missense_Mutation_p.L155V|TMC4_uc002qdo.2_Missense_Mutation_p.L435V	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	441	Helical; (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					AGGACCACCAGGGAGGCGAGG	0.577													15	30					0	0	0	0	C	54666867	C	C	54666867	3	2	141	1	0	0	0	0	1	0	0	0	16053	991	35	4	845	4	TMC4	19	54666867	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	248208	54666867	4462116	535	25810											
LAIR2	3904	broad.mit.edu	37	chr19	55019221	55019222	+	Nonsense_Mutation	DNP	GG	TT	TT																															caaacattccgcctggagagGgaggatagagccaagtacaa																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:55019221_55019222GG>TT	uc002qgc.2	+	3	308_309	c.186_187GG>TT	c.(184-189)AGGGAG>AGTTAG	p.62_63RE>S*	LAIR2_uc002qga.1_RNA|LAIR2_uc002qgb.1_RNA|LAIR2_uc002qgd.2_Nonsense_Mutation_p.62_63RE>S*|LAIR2_uc010erl.2_Nonsense_Mutation_p.62_63RE>S*	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like	62_63	Ig-like C2-type.					extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		GCCTGGAGAGGGAGGATAGAGC	0.53													50	76					0	0	0	0	TT	55019222	TT	TT	55019221	4	4	141	1	0	0	0	0	0	1	0	0	8643	1223	43	4	196	4	LAIR2	19	55019221	Nonsense_Mutation	DNP	GG	TCGA-CR-7370-01A-11D-2129-08	352354	55019221	4109762	536	25811											
LILRB4	11006	broad.mit.edu	37	chr19	55177323	55177324	+	Missense_Mutation	DNP	TC	AA	AA																															ggtggtctccatcctgcttcTctccctcctcctcttcctcc																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:55177323_55177324TC>AA	uc002qgp.2	+	7	1177_1178	c.815_816TC>AA	c.(814-816)CTC>CAA	p.L272Q	LILRB4_uc002qgq.2_Missense_Mutation_p.L272Q|LILRB4_uc002qgr.2_Missense_Mutation_p.L313Q|LILRB4_uc010ert.2_Missense_Mutation_p.L313Q|LILRB4_uc010eru.2_Missense_Mutation_p.L301Q	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	272	Helical; (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		Atcctgcttctctccctcctcc	0.431													8	20					0	0	0	0	AA	55177324	AA	AA	55177323	3	1	141	1	0	0	0	0	1	0	0	0	8834	1551	54	5	841	5	LILRB4	19	55177323	Missense_Mutation	DNP	TC	TCGA-CR-7370-01A-11D-2129-08	158102	55177323	3951660	537	25812											
NLRP8	126205	broad.mit.edu	37	chr19	56487625	56487625	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgatggggtgatcctgctGtgtgaggccctgaagaaccc	8	9	15	9	0	0	5	0	4	0	1	1	6	1	5	3	3	2	1	3	3	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:56487625G>T	uc002qmh.2	+	8	2903	c.2832G>T	c.(2830-2832)CTG>CTT	p.L944L	NLRP8_uc010etg.2_Silent_p.L925L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	944	LRR 5.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TGATCCTGCTGTGTGAGGCCC	0.463													35	50					1.07121e-22	1.55793e-22	1	0	T	56487625	T	T	56487625	2	4	141	1	0	0	0	0	0	0	0	1	10537	1364	48	4		4	NLRP8	19	56487625	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1310302	56487625	2641358	538	25813											
PEG3	5178	broad.mit.edu	37	chr19	57325220	57325220	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgcaggctcaaatatgatCatgctggcatgagttttcag	10	14	10	7	0	3	2	3	2	0	0	3	2	3	2	0	2	2	5	0	2	2	4	rs140891968		TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:57325220C>G	uc002qnu.2	-	7	4941	c.4590G>C	c.(4588-4590)ATG>ATC	p.M1530I	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.M1501I|PEG3_uc002qnv.2_Missense_Mutation_p.M1530I|PEG3_uc002qnw.2_Missense_Mutation_p.M1406I|PEG3_uc002qnx.2_Missense_Mutation_p.M1404I|PEG3_uc010etr.2_Missense_Mutation_p.M1530I	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1530					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CAAATATGATCATGCTGGCAT	0.478													44	69					0	0	0	0	G	57325220	G	G	57325220	3	3	141	1	0	0	0	0	1	0	0	0	11774	826	29	2	180	2	PEG3	19	57325220	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	837595	57325220	1803763	539	25814											
ZNF17	7565	broad.mit.edu	37	chr19	57931542	57931542	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgaatgtggcaaattgtttAggtacaactccgaccttatt	11	14	9	7	1	0	1	0	1	0	0	1	2	1	1	2	2	2	3	2	2	6	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:57931542A>C	uc002qoo.1	+	3	913	c.682A>C	c.(682-684)AGG>CGG	p.R228R	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Silent_p.R230R	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	228	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		CAAATTGTTTAGGTACAACTC	0.413													5	91					0	0	0	0	C	57931542	C	C	57931542	2	2	141	1	0	0	0	0	0	0	0	1	17810	411	15	5		5	ZNF17	19	57931542	Silent	SNP	A	TCGA-CR-7370-01A-11D-2129-08	606322	57931542	1197441	540	25815											
RSPO4	343637	broad.mit.edu	37	chr20	947818	947818	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggggaggtccccactcaccCtggcactcccgtgtgttctg	4	9	12	16	2	2	0	1	0	1	0	4	1	4	1	4	4	0	2	4	4	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:947818C>T	uc002wej.2	-	3	505	c.408G>A	c.(406-408)CAG>CAA	p.Q136Q	RSPO4_uc002wek.2_Silent_p.Q136Q	NM_001029871	NP_001025042	Q2I0M5	RSPO4_HUMAN	R-spondin family, member 4 isoform 1 precursor	136					Wnt receptor signaling pathway	extracellular region	heparin binding				0						CCCACTCACCCTGGCACTCCC	0.627													6	29					0	0	0	0	T	947818	T	T	947818	2	4	141	1	0	0	0	0	0	0	0	1	13777	695	24	4		4	RSPO4	20	947818	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08		947818	62077702	541	25816											
PSMF1	9491	broad.mit.edu	37	chr20	1144966	1144966	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttcttcttgcctcaggcctCggagaggtggcatgattgtg	5	14	13	9	1	3	2	1	1	2	1	4	3	3	2	2	4	1	1	2	4	0	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:1144966C>T	uc002wel.3	+	7	778	c.610C>T	c.(610-612)CGG>TGG	p.R204W	PSMF1_uc010zpo.1_Missense_Mutation_p.R116W|PSMF1_uc002wem.3_Missense_Mutation_p.R204W|PSMF1_uc010zpp.1_Missense_Mutation_p.R142W|PSMF1_uc002wen.3_Missense_Mutation_p.R204W|PSMF1_uc002wep.3_Missense_Mutation_p.R155W	NM_178578	NP_848693	Q92530	PSMF1_HUMAN	proteasome inhibitor subunit 1	204	Pro-rich.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding				0						CCTCAGGCCTCGGAGAGGTGG	0.552													209	236					0	0	0	0	T	1144966	T	T	1144966	3	4	141	1	0	0	0	0	1	0	0	0	12772	875	31	1	632	1	PSMF1	20	1144966	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	197148	1144966	61880554	542	25817											
BMP2	650	broad.mit.edu	37	chr20	6759467	6759467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtacgtggacttcagtgacGtggggtggaatgactggatt	8	12	16	5	2	1	2	1	2	0	0	1	5	1	5	0	5	1	1	0	5	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:6759467G>A	uc002wmu.1	+	3	1707	c.922G>A	c.(922-924)GTG>ATG	p.V308M		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	308					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	CTTCAGTGACGTGGGGTGGAA	0.507													26	87					0	0	0	0	A	6759467	A	A	6759467	3	1	141	1	0	0	0	0	1	0	0	0	1462	1145	40	1	928	1	BMP2	20	6759467	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	5614501	6759467	56266053	543	25818											
PLCB1	23236	broad.mit.edu	37	chr20	8609052	8609052	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatctcccatttgaatctcGtggctttccaagaagaagtg	11	12	8	10	1	2	3	0	1	2	2	5	3	3	3	2	1	0	1	2	1	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:8609052G>T	uc002wnb.2	+	4	361	c.358G>T	c.(358-360)GTG>TTG	p.V120L	PLCB1_uc010zrb.1_Missense_Mutation_p.V19L|PLCB1_uc010gbv.1_Missense_Mutation_p.V120L|PLCB1_uc002wmz.1_Missense_Mutation_p.V120L|PLCB1_uc002wna.2_Missense_Mutation_p.V120L|PLCB1_uc002wnc.1_Missense_Mutation_p.V19L	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	120					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TTTGAATCTCGTGGCTTTCCA	0.478													30	67					8.16721e-17	1.1025e-16	1	0	T	8609052	T	T	8609052	3	4	141	1	0	0	0	0	1	0	0	0	12082	1145	40	3	372	3	PLCB1	20	8609052	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1849585	8609052	54416468	544	25819											
SNRPB2	6629	broad.mit.edu	37	chr20	16719498	16719498	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccctatttattttgcttaggGaactccaaattcagctaata	12	15	5	9	0	1	0	1	0	0	0	2	1	2	1	2	1	3	2	2	1	7	9			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:16719498G>A	uc002wph.1	+	5	596	c.380G>A	c.(379-381)GGA>GAA	p.G127E	SNRPB2_uc002wpi.1_Missense_Mutation_p.G127E	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''	127						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						TTTGCTTAGGGAACTCCAAAT	0.299													7	22					0	0	0	0	A	16719498	A	A	16719498	3	1	141	1	0	0	0	0	1	0	0	0	14926	1188	41	2	394	2	SNRPB2	20	16719498	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	8110446	16719498	46306022	545	25820											
PAX1	5075	broad.mit.edu	37	chr20	21687098	21687098	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagacgtatggcgaggtgaaCcagctgggcggtgtgttcgt	7	9	17	8	4	0	2	0	1	0	1	1	3	0	2	1	4	2	3	1	4	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:21687098C>T	uc002wsj.2	+	2	363	c.309C>T	c.(307-309)AAC>AAT	p.N103N	PAX1_uc010zsl.1_Silent_p.N103N|PAX1_uc010zsm.1_Silent_p.N79N	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	103	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						GCGAGGTGAACCAGCTGGGCG	0.662													23	76					0	0	0	0	T	21687098	T	T	21687098	2	4	141	1	0	0	0	0	0	0	0	1	11532	506	18	4		4	PAX1	20	21687098	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4967600	21687098	41338422	546	25821											
MYLK2	85366	broad.mit.edu	37	chr20	30408307	30408307	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagccaggaggggctcacCtgcctttctgcatagcccca	8	7	11	15	0	2	0	1	0	1	0	2	1	2	1	5	3	5	3	5	3	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:30408307C>T	uc002wwq.2	+	3	533	c.431C>T	c.(430-432)CCT>CTT	p.P144L		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	144					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGGGGCTCACCTGCCTTTCTG	0.637													39	40					0	0	0	0	T	30408307	T	T	30408307	3	4	141	1	0	0	0	0	1	0	0	0	10110	681	24	4	437	4	MYLK2	20	30408307	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	8721209	30408307	32617213	547	25822											
ZNF341	84905	broad.mit.edu	37	chr20	32378871	32378871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgccgagcatcagcgcgccCacacgggcaactacaagttc	10	5	10	16	5	1	0	1	0	0	0	3	1	1	0	2	1	4	3	2	1	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:32378871C>T	uc002wzy.2	+	15	2133	c.2113C>T	c.(2113-2115)CAC>TAC	p.H705Y	ZNF341_uc002wzx.2_Missense_Mutation_p.H698Y|ZNF341_uc010geq.2_Missense_Mutation_p.H615Y|ZNF341_uc010ger.2_RNA|ZNF341_uc002wzz.2_Missense_Mutation_p.H132Y	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	705	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TCAGCGCGCCCACACGGGCAA	0.612													17	44					0	0	0	0	T	32378871	T	T	32378871	3	4	141	1	0	0	0	0	1	0	0	0	17924	594	21	4	2150	4	ZNF341	20	32378871	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	1970564	32378871	30646649	548	25823											
NCOA6	23054	broad.mit.edu	37	chr20	33337564	33337564	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcatctgagataaactgaCatcgttatttgctgtagtag	12	14	8	7	1	2	2	1	2	1	1	3	3	2	2	0	0	2	4	0	0	5	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:33337564C>A	uc002xav.2	-	10	5005	c.2434G>T	c.(2434-2436)GTC>TTC	p.V812F	NCOA6_uc002xaw.2_Missense_Mutation_p.V812F	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	812	TBP/GTF2A-binding region.|NCOA1-binding region.|NCOA6IP-binding region.|CREBBP-binding region.|Gln-rich.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						GATAAACTGACATCGTTATTT	0.542													48	71					1.56793e-16	2.11266e-16	1	0	A	33337564	A	A	33337564	3	1	141	1	0	0	0	0	1	0	0	0	10287	478	17	4	3785	4	NCOA6	20	33337564	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	958693	33337564	29687956	549	25824											
NCOA6	23054	broad.mit.edu	37	chr20	33345322	33345322	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagttgggaccctagagggcCctccctgcaaactcttcatc	8	9	10	14	0	2	1	1	0	1	1	4	3	3	2	3	2	2	2	3	2	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:33345322C>A	uc002xav.2	-	8	3800	c.1229G>T	c.(1228-1230)GGG>GTG	p.G410V	NCOA6_uc002xaw.2_Missense_Mutation_p.G410V|NCOA6_uc010gew.1_Missense_Mutation_p.G367V	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	410	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CCTAGAGGGCCCTCCCTGCAA	0.597													23	51					2.27731e-05	2.46204e-05	1	0	A	33345322	A	A	33345322	3	1	141	1	0	0	0	0	1	0	0	0	10287	623	22	4	4998	4	NCOA6	20	33345322	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	7758	33345322	29680198	550	25825											
CDH22	64405	broad.mit.edu	37	chr20	44839176	44839176	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaggatcacggtgtgcacGggctgggattcgaagtccag	8	8	15	10	3	1	0	1	0	0	0	4	3	3	2	2	4	1	2	2	4	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:44839176G>T	uc002xrm.2	-	6	1457	c.1056C>A	c.(1054-1056)CCC>CCA	p.P352P	CDH22_uc010ghk.1_Silent_p.P352P|CDH22_uc002xrn.1_Silent_p.P103P	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	352	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				CGGTGTGCACGGGCTGGGATT	0.677													16	11					2.94398e-08	3.43075e-08	1	0	T	44839176	T	T	44839176	2	4	141	1	0	0	0	0	0	0	0	1	3122	1103	39	3		3	CDH22	20	44839176	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	11493854	44839176	18186344	551	25826											
FAM65C	140876	broad.mit.edu	37	chr20	49221286	49221286	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcccgtggggctgggtgacaCcaggaagctctcagtatcaa	9	7	14	11	1	2	1	2	1	1	0	3	2	2	2	2	4	1	3	2	4	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:49221286C>G	uc002xvm.2	-	12	1288	c.970G>C	c.(970-972)GTG>CTG	p.V324L	FAM65C_uc010zyt.1_Missense_Mutation_p.V328L|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.V324L	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	324										ovary(2)	2						CTGGGTGACACCAGGAAGCTC	0.602													10	13					0	0	0	0	G	49221286	G	G	49221286	3	3	141	1	0	0	0	0	1	0	0	0	5633	507	18	4	1914	4	FAM65C	20	49221286	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4382110	49221286	13804234	552	25827											
RAB22A	57403	broad.mit.edu	37	chr20	56929251	56929254	+	Frame_Shift_Del	DEL	TATT	-	-																															gcaaaggactacgccgactcTattcatgcaatttttgtaga																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:56929251_56929254delTATT	uc002xyz.2	+	6	679_682	c.417_420delTATT	c.(415-420)TCTATTfs	p.S139fs		NM_020673	NP_065724	Q9UL26	RB22A_HUMAN	RAS-related protein RAB-22A	139_140					endocytosis|endosome organization|protein transport|small GTPase mediated signal transduction	early endosome|endosome membrane|plasma membrane	GTP binding|GTPase activity|protein binding				0	all_epithelial(3;5.09e-14)|Lung NSC(12;0.000122)|all_lung(29;0.00042)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;4.73e-08)|all cancers(14;4.83e-07)			ACGCCGACTCTATTCATGCAATTT	0.402													---	---	---								-	56929254	-	-	56929251	7	5	141	1	0	1	0	1	0	0	0	0	12974	1509	53	0	439	0	RAB22A	20	56929251	Frame_Shift_Del	DEL	TATT	TCGA-CR-7370-01A-11D-2129-08	7707965	56929251	6096269	553	25828											
LAMA5	3911	broad.mit.edu	37	chr20	60887107	60887107	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacacctggcatagcccatcCtggggacggcagccaggtca	9	5	13	14	1	1	0	1	0	0	0	2	2	2	1	4	5	2	2	4	5	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:60887107C>T	uc002ycq.2	-	70	9572	c.9505_splice	c.e70-1	p.D3169_splice		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor						angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATAGCCCATCCTGGGGACGGC	0.672													21	23					0	0	0	0	T	60887107	T	T	60887107	5	4	141	1	0	0	0	0	0	0	1	0	8649	695	24	4	1627	4	LAMA5	20	60887107	Splice_Site	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3957856	60887107	2138413	554	25829											
TPTE	7179	broad.mit.edu	37	chr21	10959762	10959762	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catatgaagcaacattttcaGcatcttcaacttcaaacttg	14	13	4	10	0	4	1	3	1	1	0	4	1	4	1	0	0	5	2	0	0	5	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:10959762G>T	uc002yip.1	-	8	580	c.212C>A	c.(211-213)GCT>GAT	p.A71D	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.A53D|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	71					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AACATTTTCAGCATCTTCAAC	0.363													9	192					2.74318e-10	3.34568e-10	1	0	T	10959762	T	T	10959762	3	4	141	1	0	0	0	0	1	0	0	0	16497	971	34	4	1511	4	TPTE	21	10959762	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08		10959762	37170133	555	25830											
TPTE	7179	broad.mit.edu	37	chr21	11012957	11012958	+	RNA	DNP	AG	CT	CT																															acaatttgtgctacaagtgaAgatccacagcagtctgagga																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:11012957_11012958AG>CT	uc002yis.1	-	9		c.1663_1664CT>AG						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTACAAGTGAAGATCCACAGCA	0.262													5	75					0	0	0	0	CT	11012958	CT	CT	11012957	1	2	141	0	1	0	0	0	0	0	0	0	16497	87	3	5		5	TPTE	21	11012957	RNA	DNP	AG	TCGA-CR-7370-01A-11D-2129-08	53195	11012957	37116938	556	25831											
DOPEY2	9980	broad.mit.edu	37	chr21	37586451	37586452	+	Frame_Shift_Ins	INS	-	T	T																															tatgaagaccagtcgtcttaINStttttttgaaaaatactcca																								rs147590869	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:37586451_37586452insT	uc002yvg.2	+	8	1056_1057	c.977_978insT	c.(976-978)TATfs	p.Y326fs	DOPEY2_uc011aeb.1_Frame_Shift_Ins_p.Y326fs	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	326					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CAGTCGTCTTATTTTTTTGAAA	0.396													---	---	---								T	37586452	T	T	37586451	7	5	141	1	0	1	1	0	0	0	0	0	4730	449	16	0	1003	0	DOPEY2	21	37586451	Frame_Shift_Ins	INS	-	TCGA-CR-7370-01A-11D-2129-08	26573494	37586451	10543444	557	25832											
DSCAM	1826	broad.mit.edu	37	chr21	41539196	41539196	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ataggctccaggtgaacttcCtgaggtggaccatcaggagc	10	8	13	10	0	1	2	1	2	0	0	3	4	3	4	3	5	2	1	3	5	2	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:41539196C>A	uc002yyq.1	-	16	3419	c.2967G>T	c.(2965-2967)CAG>CAT	p.Q989H	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	989	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGTGAACTTCCTGAGGTGGAC	0.532													18	42					7.45023e-12	9.4318e-12	1	0	A	41539196	A	A	41539196	3	1	141	1	0	0	0	0	1	0	0	0	4790	680	24	4	3143	4	DSCAM	21	41539196	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	3952745	41539196	6590699	558	25833											
KRTAP10-9	386676	broad.mit.edu	37	chr21	46047615	46047615	+	Frame_Shift_Del	DEL	C	-	-																															gccagcttgctgcacttcctCcccctgccagcagtcctact																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:46047615delC	uc002zfp.3	+	1	576	c.527delC	c.(526-528)TCCfs	p.S176fs	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	176	16.|25 X 5 AA repeats of C-C-X(3).					keratin filament					0						TGCACTTCCTCCCCCTGCCAG	0.552													---	---	---								-	46047615	-	-	46047615	7	5	141	1	0	1	0	1	0	0	0	0	8555	855	30	0	529	0	KRTAP10-9	21	46047615	Frame_Shift_Del	DEL	C	TCGA-CR-7370-01A-11D-2129-08	4508419	46047615	2082280	559	25834											
COL6A2	1292	broad.mit.edu	37	chr21	47545908	47545908	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagaagacacgtgtgtttGcggtggtcatcacggacggg	8	8	16	9	4	2	2	2	0	0	2	2	3	2	3	1	4	1	1	1	4	1	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:47545908G>T	uc002zia.1	+	26	2261	c.2179G>T	c.(2179-2181)GCG>TCG	p.A727S	COL6A2_uc002zhy.1_Missense_Mutation_p.A727S|COL6A2_uc002zhz.1_Missense_Mutation_p.A727S|COL6A2_uc002zib.1_Missense_Mutation_p.A133S|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	727	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACGTGTGTTTGCGGTGGTCAT	0.657													12	31					3.03607e-14	3.98111e-14	1	0	T	47545908	T	T	47545908	3	4	141	1	0	0	0	0	1	0	0	0	3715	1319	46	4	2277	4	COL6A2	21	47545908	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1498293	47545908	583987	560	25835											
MICAL3	57553	broad.mit.edu	37	chr22	18300912	18300912	+	Frame_Shift_Del	DEL	G	-	-																															gacttccgcacctcctctctGgggggctgagcaggctcccg																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:18300912delG	uc002zng.3	-	26	4868	c.4515delC	c.(4513-4515)CCCfs	p.P1505fs	MICAL3_uc011agl.1_Frame_Shift_Del_p.P1421fs|MICAL3_uc010gre.1_5'Flank	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1505	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CCTCCTCTCTGGGGGGCTGAG	0.652													---	---	---								-	18300912	-	-	18300912	7	5	141	1	0	1	0	1	0	0	0	0	9624	1335	47	0	1521	0	MICAL3	22	18300912	Frame_Shift_Del	DEL	G	TCGA-CR-7370-01A-11D-2129-08		18300912	33003654	561	25836											
ZNF74	7625	broad.mit.edu	37	chr22	20760750	20760750	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagcccttcaagtgcaacgAgtgcggcaaagccttcagct	11	7	11	12	2	2	0	2	0	0	0	2	2	2	0	2	1	6	3	2	1	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:20760750A>C	uc010gsm.2	+	6	1639	c.1427A>C	c.(1426-1428)GAG>GCG	p.E476A	ZNF74_uc002zsg.2_Missense_Mutation_p.E405A|ZNF74_uc002zsh.2_Missense_Mutation_p.E476A|ZNF74_uc002zsi.2_Missense_Mutation_p.E405A|ZNF74_uc010gsn.2_Missense_Mutation_p.E405A	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	476	C2H2-type 9.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AAGTGCAACGAGTGCGGCAAA	0.642													25	53					0	0	0	0	C	20760750	C	C	20760750	3	2	141	1	0	0	0	0	1	0	0	0	18194	304	11	5	1445	5	ZNF74	22	20760750	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	2459838	20760750	30543816	562	25837											
BPIL2	254240	broad.mit.edu	37	chr22	32828502	32828502	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccatgatcctcaccatgaagGgctgggacaagatgtagatc	12	8	11	10	0	1	4	1	2	0	2	3	5	2	5	3	2	0	2	3	2	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:32828502G>T	uc003amn.2	-	10	1007	c.1007C>A	c.(1006-1008)CCC>CAC	p.P336H	BPIL2_uc010gwo.2_Intron|BPIL2_uc011amb.1_Missense_Mutation_p.P60H	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	336						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						CACCATGAAGGGCTGGGACAA	0.488													33	66					4.4194e-11	5.50922e-11	1	0	T	32828502	T	T	32828502	3	4	141	1	0	0	0	0	1	0	0	0	1497	1232	43	4	540	4	BPIL2	22	32828502	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	12067752	32828502	18476064	563	25838											
TRIOBP	11078	broad.mit.edu	37	chr22	38121264	38121264	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attcatctccccatcgtactAacaaagacatcccctgggcc	11	9	5	16	1	2	1	1	0	1	1	5	1	3	1	5	1	2	1	5	1	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:38121264A>T	uc003atr.2	+	7	2972	c.2701A>T	c.(2701-2703)AAC>TAC	p.N901Y	TRIOBP_uc003atu.2_Missense_Mutation_p.N729Y|TRIOBP_uc003atq.1_Missense_Mutation_p.N901Y|TRIOBP_uc003ats.1_Missense_Mutation_p.N729Y	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	901					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCATCGTACTAACAAAGACAT	0.547													99	156					0	0	0	0	T	38121264	T	T	38121264	3	4	141	1	0	0	0	0	1	0	0	0	16620	362	13	5	2719	5	TRIOBP	22	38121264	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	5292762	38121264	13183302	564	25839											
GCAT	23464	broad.mit.edu	37	chr22	38212669	38212669	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatagcgaggaagacattGaccgctgcgtggaggccttc	9	8	14	10	3	0	2	0	1	0	1	1	5	0	4	2	3	3	2	2	3	2	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:38212669G>T	uc003atz.2	+	9	1224	c.1204G>T	c.(1204-1206)GAC>TAC	p.D402Y	GCAT_uc003aua.1_Missense_Mutation_p.D428Y	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	402					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GGAAGACATTGACCGCTGCGT	0.627													43	60					7.53189e-24	1.10639e-23	1	0	T	38212669	T	T	38212669	3	4	141	1	0	0	0	0	1	0	0	0	6319	1290	45	2	1316	2	GCAT	22	38212669	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	91405	38212669	13091897	565	25840											
NPTXR	23467	broad.mit.edu	37	chr22	39219124	39219124	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataaggatcccatgaggcttGatggggtgccaggcagccag	10	7	15	9	0	0	2	0	2	0	0	1	3	1	3	3	5	2	2	3	5	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:39219124G>C	uc003awk.2	-	4	1396	c.1242C>G	c.(1240-1242)ATC>ATG	p.I414M		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	414	Pentaxin.|Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					CATGAGGCTTGATGGGGTGCC	0.502													28	67					0	0	0	0	C	39219124	C	C	39219124	3	2	141	1	0	0	0	0	1	0	0	0	10658	1280	45	2	268	2	NPTXR	22	39219124	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1006455	39219124	12085442	566	25841											
ENTHD1	150350	broad.mit.edu	37	chr22	40140270	40140270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggagaaaaggaagatgctCcctcagaagcagttgaaact	17	6	11	7	0	1	4	1	1	0	3	2	6	2	5	1	2	3	3	1	2	6	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:40140270C>T	uc003ayg.2	-	7	1489	c.1238G>A	c.(1237-1239)GGA>GAA	p.G413E		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	413										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GGAAGATGCTCCCTCAGAAGC	0.363													8	41					0	0	0	0	T	40140270	T	T	40140270	3	4	141	1	0	0	0	0	1	0	0	0	5161	855	30	2	589	2	ENTHD1	22	40140270	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	921146	40140270	11164296	567	25842											
PKDREJ	10343	broad.mit.edu	37	chr22	46657867	46657867	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gctatggcttttggtccttgGagcacgtggaccctcttatc	5	14	11	11	1	1	0	0	0	1	0	3	2	2	2	2	4	1	3	2	4	2	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:46657867G>C	uc003bhh.2	-	1	1353	c.1353C>G	c.(1351-1353)CTC>CTG	p.L451L		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	451	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TTGGTCCTTGGAGCACGTGGA	0.408													43	40					0	0	0	0	C	46657867	C	C	46657867	2	2	141	1	0	0	0	0	0	0	0	1	12025	1161	41	2		2	PKDREJ	22	46657867	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	6517597	46657867	4646699	568	25843											
PKDREJ	10343	broad.mit.edu	37	chr22	46658330	46658330	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catacactccccactgtaacGaattattggggatgtgaatg	12	11	9	9	1	0	1	0	1	0	0	1	3	1	2	2	2	2	1	2	2	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:46658330G>A	uc003bhh.2	-	1	890	c.890C>T	c.(889-891)TCG>TTG	p.S297L		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	297	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CCACTGTAACGAATTATTGGG	0.572													125	132					0	0	0	0	A	46658330	A	A	46658330	3	1	141	1	0	0	0	0	1	0	0	0	12025	1059	37	1	5875	1	PKDREJ	22	46658330	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	463	46658330	4646236	569	25844											
TUBGCP6	85378	broad.mit.edu	37	chr22	50665439	50665439	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaactcacggtgggaaacgCggccctggggcctcctccac	8	5	12	16	3	1	0	1	0	0	0	3	1	3	1	4	5	2	0	4	5	2	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:50665439C>A	uc003bkb.1	-	6	1992	c.1480G>T	c.(1480-1482)GCG>TCG	p.A494S	TUBGCP6_uc010har.1_Missense_Mutation_p.A494S|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'Flank|TUBGCP6_uc003bkd.1_5'Flank	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	494					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GTGGGAAACGCGGCCCTGGGG	0.687													4	10					0.000602214	0.000634229	1	0	A	50665439	A	A	50665439	3	1	141	1	0	0	0	0	1	0	0	0	16838	768	27	3	4059	3	TUBGCP6	22	50665439	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	4007109	50665439	639127	570	25845											
MAPK8IP2	23542	broad.mit.edu	37	chr22	51041671	51041671	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggacagcctctccctggggcGctcggagcagccgcacccca	6	4	13	18	3	1	0	0	0	1	0	3	2	1	2	5	4	3	3	5	4	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:51041671G>T	uc003bmx.2	+	3	308	c.191G>T	c.(190-192)CGC>CTC	p.R64L	MAPK8IP2_uc003bmy.2_Missense_Mutation_p.R37L|MAPK8IP2_uc011asc.1_5'Flank	NM_012324	NP_036456	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting	64					behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			large_intestine(2)|central_nervous_system(1)	3		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCCCTGGGGCGCTCGGAGCAG	0.527													16	14					2.32078e-09	2.7751e-09	1	0	T	51041671	T	T	51041671	3	4	141	1	0	0	0	0	1	0	0	0	9338	1087	38	3	291	3	MAPK8IP2	22	51041671	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	376232	51041671	262895	571	25846											
MXRA5	25878	broad.mit.edu	37	chrX	3235181	3235181	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcctcttggacggcagccTccagaggatgcgcggccagg	7	6	14	14	3	1	1	0	0	1	1	3	3	3	3	4	5	2	1	4	5	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:3235181T>A	uc004crg.3	-	6	6698	c.6541A>T	c.(6541-6543)AGG>TGG	p.R2181W		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2181	Ig-like C2-type 6.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GACGGCAGCCTCCAGAGGATG	0.652													3	8					0	0	0	0	A	3235181	A	A	3235181	3	1	141	1	0	0	0	0	1	0	0	0	10056	1550	54	5	1953	5	MXRA5	23	3235181	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08		3235181	152035379	572	25847											
NLGN4X	57502	broad.mit.edu	37	chrX	5821198	5821198	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaaaagttacaactgaaGagctcggtgggaccgatcat	13	9	12	7	2	1	2	1	1	0	1	2	5	1	4	1	3	3	2	1	3	5	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:5821198G>T	uc010ndh.2	-	5	2022	c.1521C>A	c.(1519-1521)CTC>CTA	p.L507L	NLGN4X_uc004crp.2_Silent_p.L527L|NLGN4X_uc004crq.2_Silent_p.L507L|NLGN4X_uc010ndi.2_Silent_p.L544L|NLGN4X_uc004crr.2_Silent_p.L507L|NLGN4X_uc010ndj.2_Silent_p.L507L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	507	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TACAACTGAAGAGCTCGGTGG	0.537													17	53					3.45872e-05	3.73378e-05	1	0	T	5821198	T	T	5821198	2	4	141	1	0	0	0	0	0	0	0	1	10518	929	33	2		2	NLGN4X	23	5821198	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2586017	5821198	149449362	573	25848											
FAM9B	171483	broad.mit.edu	37	chrX	8997416	8997416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctgtgatgtattcttcaaGgacatttagcaacttcagag	11	14	9	7	0	4	2	2	1	2	1	4	3	4	3	0	1	2	2	0	1	4	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:8997416G>A	uc011mhu.1	-	5	414	c.325C>T	c.(325-327)CTT>TTT	p.L109F	FAM9B_uc011mhv.1_RNA|FAM9B_uc004csh.2_Missense_Mutation_p.L149F	NM_205849	NP_995321	Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	109						nucleus					0		Hepatocellular(5;0.219)				TATTCTTCAAGGACATTTAGC	0.289													4	25					0	0	0	0	A	8997416	A	A	8997416	3	1	141	1	0	0	0	0	1	0	0	0	5692	1000	35	4	247	4	FAM9B	23	8997416	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3176218	8997416	146273144	574	25849											
SHROOM2	357	broad.mit.edu	37	chrX	9862691	9862691	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgggaggctcccaggcaggGtggccggcaggcccaggccg	5	3	19	14	2	0	0	0	0	0	0	1	1	1	1	4	8	0	3	4	8	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:9862691G>T	uc004csu.1	+	4	833	c.743G>T	c.(742-744)GGT>GTT	p.G248V		NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	248					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CCCAGGCAGGGTGGCCGGCAG	0.667													3	13					2.56e-06	2.85613e-06	1	0	T	9862691	T	T	9862691	3	4	141	1	0	0	0	0	1	0	0	0	14359	1261	44	4	757	4	SHROOM2	23	9862691	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	865275	9862691	145407869	575	25850											
FRMPD4	9758	broad.mit.edu	37	chrX	12632926	12632926	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgaaggcaagctgatcccGggagatcagattgtaatgat	12	10	12	7	1	2	5	1	3	1	2	3	6	3	5	1	2	1	3	1	2	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:12632926G>A	uc004cuz.1	+	4	854	c.348G>A	c.(346-348)CCG>CCA	p.P116P	FRMPD4_uc011mij.1_Silent_p.P108P	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	116	PDZ.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGCTGATCCCGGGAGATCAGA	0.517													21	73					0	0	0	0	A	12632926	A	A	12632926	2	1	141	1	0	0	0	0	0	0	0	1	6093	1103	39	1		1	FRMPD4	23	12632926	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	2770235	12632926	142637634	576	25851											
TLR7	51284	broad.mit.edu	37	chrX	12905663	12905663	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatgcctccaaatctaaagaAtctctctttggccaaaaatg	14	12	5	10	0	3	1	0	0	3	1	5	1	4	1	3	1	1	0	3	1	7	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:12905663A>G	uc004cvc.2	+	3	2175	c.2036A>G	c.(2035-2037)AAT>AGT	p.N679S		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	679	Extracellular (Potential).|LRR 23.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	AATCTAAAGAATCTCTCTTTG	0.393													40	131					0	0	0	0	G	12905663	G	G	12905663	3	3	141	1	0	0	0	0	1	0	0	0	16022	101	4	5	2042	5	TLR7	23	12905663	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	272737	12905663	142364897	577	25852											
BMX	660	broad.mit.edu	37	chrX	15543445	15543445	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatgttgcaagcagtaacCaaaaagaaagaaatgtgaat	21	7	9	4	0	0	4	0	1	0	3	0	4	0	4	1	0	3	4	1	0	8	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:15543445C>G	uc004cww.2	+	8	975	c.787C>G	c.(787-789)CAA>GAA	p.Q263E	BMX_uc004cwx.3_Missense_Mutation_p.Q263E|BMX_uc004cwy.3_Missense_Mutation_p.Q263E	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	263					cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AAGCAGTAACCAAAAAGAAAG	0.313													15	68					0	0	0	0	G	15543445	G	G	15543445	3	3	141	1	0	0	0	0	1	0	0	0	1476	595	21	4	813	4	BMX	23	15543445	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	2637782	15543445	139727115	578	25853											
CDKL5	6792	broad.mit.edu	37	chrX	18622489	18622489	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcctctaggagtccctcctAcaggaccaaggccaaaagcc	11	6	9	15	0	1	0	0	0	1	0	4	2	4	2	6	3	2	0	6	3	5	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:18622489A>G	uc004cym.2	+	12	1698	c.1445A>G	c.(1444-1446)TAC>TGC	p.Y482C	CDKL5_uc004cyn.2_Missense_Mutation_p.Y482C	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	482					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					AGTCCCTCCTACAGGACCAAG	0.532													21	114					0	0	0	0	G	18622489	G	G	18622489	3	3	141	1	0	0	0	0	1	0	0	0	3172	391	14	5	1487	5	CDKL5	23	18622489	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	3079044	18622489	136648071	579	25854											
ACOT9	23597	broad.mit.edu	37	chrX	23723192	23723192	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctaccacaaacggtcgaGaaccactgttgggggaaagg	12	6	13	10	2	0	1	0	0	0	1	1	3	0	2	2	4	4	2	2	4	4	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:23723192G>A	uc004dap.2	-	13	1144	c.998C>T	c.(997-999)TCT>TTT	p.S333F	ACOT9_uc004dan.2_Missense_Mutation_p.S83F|ACOT9_uc004dao.2_Missense_Mutation_p.S342F|ACOT9_uc004daq.2_Missense_Mutation_p.S291F|ACOT9_uc004dar.2_Missense_Mutation_p.S273F|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Missense_Mutation_p.S273F	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	333					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						AAACGGTCGAGAACCACTGTT	0.408													46	68					0	0	0	0	A	23723192	A	A	23723192	3	1	141	1	0	0	0	0	1	0	0	0	157	942	33	2	333	2	ACOT9	23	23723192	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	5100703	23723192	131547368	580	25855											
MAGEB4	4115	broad.mit.edu	37	chrX	30260834	30260834	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaccagagcagtgcctggacCcttccaaggaatgggcttct	10	8	11	12	0	1	1	0	0	1	1	2	3	2	3	4	3	3	2	4	3	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:30260834C>A	uc004dcb.2	+	1	666	c.582C>A	c.(580-582)ACC>ACA	p.T194T	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	194	MAGE.									ovary(1)	1						GTGCCTGGACCCTTCCAAGGA	0.522													16	17					0.00316338	0.00328436	1	0	A	30260834	A	A	30260834	2	1	141	1	0	0	0	0	0	0	0	1	9231	610	22	4		4	MAGEB4	23	30260834	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	6537642	30260834	125009726	581	25856											
NR0B1	190	broad.mit.edu	37	chrX	30326619	30326619	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagggacgcccagcagttgcGcaccagcaccagctgctggt	8	5	13	15	2	0	0	0	0	0	0	0	1	0	1	3	2	5	6	3	2	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:30326619G>T	uc004dcf.3	-	1	877	c.862C>A	c.(862-864)CGC>AGC	p.R288S		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	288	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	CAGCAGTTGCGCACCAGCACC	0.632											OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	7					2.56e-06	2.85613e-06	1	0	T	30326619	T	T	30326619	3	4	141	1	0	0	0	0	1	0	0	0	10667	1087	38	3	558	3	NR0B1	23	30326619	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	65785	30326619	124943941	582	25857											
NR0B1	190	broad.mit.edu	37	chrX	30327199	30327199	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgtcgcctcgggcgccttCggtgccgcgtacgtttgctt	2	11	14	14	8	0	0	0	0	0	0	3	0	0	0	3	2	4	3	3	2	1	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:30327199C>T	uc004dcf.3	-	1	297	c.282G>A	c.(280-282)CCG>CCA	p.P94P		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	94	4 X 67 AA tandem repeats.|2.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	CGGGCGCCTTCGGTGCCGCGT	0.687													16	18					0	0	0	0	T	30327199	T	T	30327199	2	4	141	1	0	0	0	0	0	0	0	1	10667	871	31	1		1	NR0B1	23	30327199	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	580	30327199	124943361	583	25858											
CXorf59	286464	broad.mit.edu	37	chrX	36122647	36122647	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcccgtgtagtgccatactGcagcaataatatgcccccca	11	9	7	14	1	0	0	0	0	0	0	1	0	1	0	5	0	5	3	5	0	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:36122647G>T	uc004ddk.1	+	8	1070	c.884G>T	c.(883-885)TGC>TTC	p.C295F		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	295						integral to membrane				central_nervous_system(1)	1						GTGCCATACTGCAGCAATAAT	0.343													23	92					6.07407e-21	8.62848e-21	1	0	T	36122647	T	T	36122647	3	4	141	1	0	0	0	0	1	0	0	0	4132	1319	46	4	910	4	CXorf59	23	36122647	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	5795448	36122647	119147913	584	25859											
CXorf38	159013	broad.mit.edu	37	chrX	40498350	40498350	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcacattcctcaggtccttGtttgtctgctagtcctcggg	5	15	9	12	1	3	0	2	0	1	0	7	0	6	0	3	2	1	2	3	2	1	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:40498350G>T	uc004dew.2	-	3	387	c.382C>A	c.(382-384)CAA>AAA	p.Q128K	CXorf38_uc011mko.1_Intron|CXorf38_uc004dev.1_Missense_Mutation_p.Q9K|CXorf38_uc010nhd.2_RNA	NM_144970	NP_659407	Q8TB03	CX038_HUMAN	hypothetical protein LOC159013	128										ovary(1)	1						TCAGGTCCTTGTTTGTCTGCT	0.498													13	75					6.72482e-11	8.31247e-11	1	0	T	40498350	T	T	40498350	3	4	141	1	0	0	0	0	1	0	0	0	4124	1386	48	4	593	4	CXorf38	23	40498350	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	4375703	40498350	114772210	585	25860											
ZNF157	7712	broad.mit.edu	37	chrX	47272966	47272966	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacataggctggtcctggcgTtgtacaatgaagaaagcctc	11	9	11	10	1	0	2	0	1	0	1	2	2	1	2	2	3	2	3	2	3	5	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:47272966T>G	uc004dhr.1	+	4	1563	c.1494T>G	c.(1492-1494)CGT>CGG	p.R498R		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	498					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGTCCTGGCGTTGTACAATGA	0.502													20	79					0	0	0	0	G	47272966	G	G	47272966	2	3	141	1	0	0	0	0	0	0	0	1	17804	1712	60	5		5	ZNF157	23	47272966	Silent	SNP	T	TCGA-CR-7370-01A-11D-2129-08	6774616	47272966	107997594	586	25861											
PORCN	64840	broad.mit.edu	37	chrX	48370283	48370283	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcacctttttcctcagtgaGatgcacatggtagacaccgt	10	11	9	11	1	1	2	1	1	0	2	2	3	2	2	3	1	2	3	3	1	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:48370283G>A	uc010nie.1	+	4	491	c.333G>A	c.(331-333)GAG>GAA	p.E111E	PORCN_uc004djq.1_Silent_p.E224E|PORCN_uc004djr.1_Silent_p.E111E|PORCN_uc004djs.1_Silent_p.E111E|PORCN_uc004djt.1_Silent_p.E40E|PORCN_uc011mlx.1_Silent_p.E40E|PORCN_uc004dju.1_5'UTR|PORCN_uc004djv.1_Silent_p.E111E|PORCN_uc004djw.1_Silent_p.E111E	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	111	Helical; (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						TCCTCAGTGAGATGCACATGG	0.597											OREG0019764	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	61					0	0	0	0	A	48370283	A	A	48370283	2	1	141	1	0	0	0	0	0	0	0	1	12313	933	33	2		2	PORCN	23	48370283	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1097317	48370283	106900277	587	25862											
HDAC6	10013	broad.mit.edu	37	chrX	48678561	48678561	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctggctttgatgctgcacggGgggatccgctggggggctgc	3	9	19	10	2	0	1	0	1	0	0	1	2	1	2	1	7	3	5	1	7	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:48678561G>T	uc011mmi.1	+	23	2331	c.2236G>T	c.(2236-2238)GGG>TGG	p.G746W	HDAC6_uc004dks.1_Missense_Mutation_p.G746W|HDAC6_uc010nig.1_Missense_Mutation_p.G594W|HDAC6_uc004dkt.1_Missense_Mutation_p.G746W|HDAC6_uc011mmk.1_Missense_Mutation_p.G727W|HDAC6_uc004dkv.1_Missense_Mutation_p.G394W|HDAC6_uc004dkw.1_Missense_Mutation_p.G394W|HDAC6_uc004dkx.1_Missense_Mutation_p.G109W	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	746	Histone deacetylase 2.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	TGCTGCACGGGGGGATCCGCT	0.572													15	74					1.15088e-07	1.30993e-07	1	0	T	48678561	T	T	48678561	3	4	141	1	0	0	0	0	1	0	0	0	7050	1232	43	4	2322	4	HDAC6	23	48678561	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	308278	48678561	106591999	588	25863											
HDAC6	10013	broad.mit.edu	37	chrX	48681696	48681696	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctgtgggaggagccattctgGaccagaccacctcagaggat	10	7	13	11	0	2	2	1	0	1	2	2	6	2	6	4	4	1	0	4	4	0	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:48681696G>C	uc011mmi.1	+	25	2982	c.2887G>C	c.(2887-2889)GAC>CAC	p.D963H	HDAC6_uc004dks.1_Missense_Mutation_p.D963H|HDAC6_uc010nig.1_Missense_Mutation_p.D811H|HDAC6_uc004dkt.1_Missense_Mutation_p.D963H|HDAC6_uc011mmk.1_Missense_Mutation_p.D944H|HDAC6_uc004dkv.1_Missense_Mutation_p.D611H|HDAC6_uc004dkw.1_Missense_Mutation_p.D611H|HDAC6_uc004dkx.1_Missense_Mutation_p.D326H	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	963					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	AGCCATTCTGGACCAGACCAC	0.647													3	14					0	0	0	0	C	48681696	C	C	48681696	3	2	141	1	0	0	0	0	1	0	0	0	7050	1174	41	2	2981	2	HDAC6	23	48681696	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3135	48681696	106588864	589	25864											
SLC35A2	7355	broad.mit.edu	37	chrX	48762559	48762559	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgaagccggaggagagacaGgaggccacgacggctgccag	11	1	18	11	4	0	1	0	0	0	1	0	7	0	4	3	5	2	1	3	5	1	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:48762559G>A	uc004dlo.1	-	4	631	c.627C>T	c.(625-627)TCC>TCT	p.S209S	SLC35A2_uc011mml.1_Silent_p.S222S|SLC35A2_uc004dlp.1_Silent_p.S209S|SLC35A2_uc011mmm.1_Silent_p.S237S|SLC35A2_uc011mmn.1_Silent_p.S148S|SLC35A2_uc004dlr.1_Intron|SLC35A2_uc004dlq.2_Intron	NM_005660	NP_005651	P78381	S35A2_HUMAN	solute carrier family 35, member A2 isoform a	209	Helical; (Potential).				galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)	1						AGGAGAGACAGGAGGCCACGA	0.647													9	7					0	0	0	0	A	48762559	A	A	48762559	2	1	141	1	0	0	0	0	0	0	0	1	14635	987	35	4		4	SLC35A2	23	48762559	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	80863	48762559	106508001	590	25865											
GPKOW	27238	broad.mit.edu	37	chrX	48979050	48979051	+	Silent	DNP	GG	TT	TT																															tgtggatggcccagggggccGggctggtggctgcctgcgat																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:48979050_48979051GG>TT	uc004dmr.2	-	2	259_260	c.252_253CC>AA	c.(250-255)GCCCGG>GCAAGG	p.84_85AR>AR		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	84_85						nucleus	nucleic acid binding			ovary(2)	2						CCAGGGGGCCGGGCTGGTGGCT	0.629													12	23					0	0	0	0	TT	48979051	TT	TT	48979050	2	4	141	1	0	0	0	0	0	0	0	1	6651	1115	39	3		3	GPKOW	23	48979050	Silent	DNP	GG	TCGA-CR-7370-01A-11D-2129-08	216491	48979050	106291510	591	25866											
CCDC22	28952	broad.mit.edu	37	chrX	49099871	49099871	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagctctgccagcagacgggCcgggaccggccaggggatga	8	3	17	13	3	1	2	0	1	1	1	1	4	1	4	4	5	3	2	4	5	0	0			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:49099871C>T	uc004dnd.1	+	6	813	c.657C>T	c.(655-657)GGC>GGT	p.G219G	CCDC22_uc011mna.1_Silent_p.G219G|CCDC22_uc004dnc.1_RNA	NM_014008	NP_054727	O60826	CCD22_HUMAN	coiled-coil domain containing 22	219										central_nervous_system(1)	1						AGCAGACGGGCCGGGACCGGC	0.682													7	13					0	0	0	0	T	49099871	T	T	49099871	2	4	141	1	0	0	0	0	0	0	0	1	2810	726	26	4		4	CCDC22	23	49099871	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	120821	49099871	106170689	592	25867											
GAGE10	643832	broad.mit.edu	37	chrX	49173663	49173663	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgaagcctgaagctgataGccaggaacaggttcacccaa	13	5	11	12	1	1	2	1	2	0	0	1	4	1	3	4	2	4	2	4	2	5	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:49173663G>C	uc010nir.1	+	4	340	c.224G>C	c.(223-225)AGC>ACC	p.S75T	GAGE10_uc010nis.2_RNA	NM_001098413	NP_001091883	A6NGK3	GAG10_HUMAN	G antigen 10	75											0	Ovarian(276;0.236)					GAAGCTGATAGCCAGGAACAG	0.423													68	152					0	0	0	0	C	49173663	C	C	49173663	3	2	141	1	0	0	0	0	1	0	0	0	6221	971	34	4	234	4	GAGE10	23	49173663	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	73792	49173663	106096897	593	25868											
AKAP4	8852	broad.mit.edu	37	chrX	49958928	49958928	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggatgctctgtgatattCgccctctgtgtctcctactt	6	15	9	11	1	3	2	0	1	3	1	5	3	3	3	2	1	2	1	2	1	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:49958928C>A	uc004dow.1	-	5	560	c.436G>T	c.(436-438)GAA>TAA	p.E146*	AKAP4_uc004dov.1_Nonsense_Mutation_p.E137*|AKAP4_uc010njp.1_5'UTR|AKAP4_uc004dou.1_Nonsense_Mutation_p.E137*	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	146				E -> D (in Ref. 2; AAC79433).	cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					CTGTGATATTCGCCCTCTGTG	0.448													55	46					5.39261e-20	7.61616e-20	1	0	A	49958928	A	A	49958928	4	1	141	1	0	0	0	0	0	1	0	0	453	893	31	3	2136	3	AKAP4	23	49958928	Nonsense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	785265	49958928	105311632	594	25869											
IQSEC2	23096	broad.mit.edu	37	chrX	53276218	53276218	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgacgctgggactgtacatGtcggtattgaggaggatgat	9	12	15	5	2	0	3	0	3	0	0	1	6	0	6	0	4	1	3	0	4	2	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:53276218G>A	uc004dsd.2	-	8	2883	c.2682C>T	c.(2680-2682)GAC>GAT	p.D894D	IQSEC2_uc004dsc.2_Silent_p.D689D	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	884	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						GACTGTACATGTCGGTATTGA	0.517													9	46					0	0	0	0	A	53276218	A	A	53276218	2	1	141	1	0	0	0	0	0	0	0	1	7857	1368	48	4		4	IQSEC2	23	53276218	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	3317290	53276218	101994342	595	25870											
RIBC1	158787	broad.mit.edu	37	chrX	53455483	53455483	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagacctagacagggacaCacggctgagaatgcagcagg	14	3	15	9	1	0	3	0	1	0	3	0	6	0	5	1	4	2	3	1	4	3	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:53455483C>G	uc004dsk.2	+	5	605	c.452C>G	c.(451-453)ACA>AGA	p.T151R	RIBC1_uc004dsj.1_Missense_Mutation_p.T151R|RIBC1_uc011mog.1_Intron	NM_001031745	NP_001026915	Q8N443	RIBC1_HUMAN	RIB43A domain with coiled-coils 1 isoform 1	151											0						GACAGGGACACACGGCTGAGA	0.507													14	18					0	0	0	0	G	53455483	G	G	53455483	3	3	141	1	0	0	0	0	1	0	0	0	13417	478	17	4	462	4	RIBC1	23	53455483	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	179265	53455483	101815077	596	25871											
HUWE1	10075	broad.mit.edu	37	chrX	53658553	53658553	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgtgaatataatgtagtGtgttactagttgtctaaaat	13	17	8	3	0	1	1	0	1	1	0	1	1	1	1	0	0	1	3	0	0	9	8			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:53658553G>C	uc004dsp.2	-	10	1061	c.659C>G	c.(658-660)ACA>AGA	p.T220R		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	220					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						ATAATGTAGTGTGTTACTAGT	0.378													18	63					0	0	0	0	C	53658553	C	C	53658553	3	2	141	1	0	0	0	0	1	0	0	0	7500	1377	48	4	12765	4	HUWE1	23	53658553	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	203070	53658553	101612007	597	25872											
FAM123B	139285	broad.mit.edu	37	chrX	63413127	63413127	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtactcccagaggctgcagCtcccttggcctgagcagctt	6	9	12	14	0	0	2	0	1	0	1	2	2	2	2	3	3	5	6	3	3	1	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:63413127C>T	uc004dvo.2	-	2	313	c.40G>A	c.(40-42)GCT>ACT	p.A14T		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	14					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GAGGCTGCAGCTCCCTTGGCC	0.557													20	88					0	0	0	0	T	63413127	T	T	63413127	3	4	141	1	0	0	0	0	1	0	0	0	5451	797	28	4	3371	4	FAM123B	23	63413127	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	9754574	63413127	91857433	598	25873											
MSN	4478	broad.mit.edu	37	chrX	64957172	64957172	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccttgctgcaggcctcccGggaccagaaaaagactcagg	10	5	13	13	1	1	2	1	0	0	2	2	3	2	3	4	4	2	2	4	4	2	1			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:64957172G>T	uc004dwf.2	+	10	1421	c.1223G>T	c.(1222-1224)CGG>CTG	p.R408L		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	408					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						CAGGCCTCCCGGGACCAGAAA	0.542			T	ALK	ALCL								5	13					1.23904e-05	1.35555e-05	1	0	T	64957172	T	T	64957172	3	4	141	1	0	0	0	0	1	0	0	0	9938	1116	39	3	1261	3	MSN	23	64957172	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	1544045	64957172	90313388	599	25874											
ATRX	546	broad.mit.edu	37	chrX	76939151	76939151	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaacttccatagcagtctCaagattctcaaaaatgtctt	13	13	5	10	0	3	2	2	1	3	1	6	2	4	2	1	0	2	1	1	0	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:76939151C>G	uc004ecp.3	-	9	1829	c.1597G>C	c.(1597-1599)GAG>CAG	p.E533Q	ATRX_uc004ecq.3_Missense_Mutation_p.E495Q|ATRX_uc004eco.3_Missense_Mutation_p.E318Q|ATRX_uc004ecr.2_Missense_Mutation_p.E494Q|ATRX_uc010nlx.1_Missense_Mutation_p.E533Q|ATRX_uc010nly.1_Missense_Mutation_p.E478Q	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	533					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATAGCAGTCTCAAGATTCTCA	0.393			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						159	124					0	0	0	0	G	76939151	G	G	76939151	3	3	141	1	0	0	0	0	1	0	0	0	1210	835	29	2	5989	2	ATRX	23	76939151	Missense_Mutation	SNP	C	TCGA-CR-7370-01A-11D-2129-08	11981979	76939151	78331409	600	25875											
KLHL4	56062	broad.mit.edu	37	chrX	86890748	86890754	+	Frame_Shift_Del	DEL	GCTCCAG	-	-																															tgcccctgcttccaaccattGctccaggctttctgactgtg																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:86890748_86890754delGCTCCAG	uc004efb.2	+	9	2080_2086	c.1898_1904delGCTCCAG	c.(1897-1905)TGCTCCAGGfs	p.C633fs	KLHL4_uc004efa.2_Frame_Shift_Del_p.C633fs	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	633_635	Kelch 5.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TCCAACCATTGCTCCAGGCTTTCTGAC	0.382													---	---	---								-	86890754	-	-	86890748	7	5	141	1	0	1	0	1	0	0	0	0	8430	1319	46	0	1932	0	KLHL4	23	86890748	Frame_Shift_Del	DEL	GCTCCAG	TCGA-CR-7370-01A-11D-2129-08	9951597	86890748	68379812	601	25876											
KLHL4	56062	broad.mit.edu	37	chrX	86919890	86919890	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgacggacatacttatttGaacacagttgagtcatatga	14	13	8	6	1	1	4	1	4	0	0	1	5	1	5	0	1	2	1	0	1	5	6			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:86919890G>A	uc004efb.2	+	10	2234	c.2052G>A	c.(2050-2052)TTG>TTA	p.L684L	KLHL4_uc004efa.2_Silent_p.L684L	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	684	Kelch 6.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						ATACTTATTTGAACACAGTTG	0.383													23	18					0	0	0	0	A	86919890	A	A	86919890	2	1	141	1	0	0	0	0	0	0	0	1	8430	1281	45	2		2	KLHL4	23	86919890	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	29142	86919890	68350670	602	25877											
PCDH11X	27328	broad.mit.edu	37	chrX	91133291	91133292	+	Missense_Mutation	DNP	GG	TT	TT																															tccaactgttcttatgaattGgttctaccgtccactaatcc																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:91133291_91133292GG>TT	uc004efk.1	+	2	2897_2898	c.2052_2053GG>TT	c.(2050-2055)TTGGTT>TTTTTT	p.684_685LV>FF	PCDH11X_uc004efl.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc004efo.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc010nmv.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc004efm.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc004efn.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc004efh.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc004efj.1_Missense_Mutation_p.684_685LV>FF	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	684_685	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTTATGAATTGGTTCTACCGTC	0.426													73	53					0	0	0	0	TT	91133292	TT	TT	91133291	3	4	141	1	0	0	0	0	1	0	0	0	11562	1339	47	4	2058	4	PCDH11X	23	91133291	Missense_Mutation	DNP	GG	TCGA-CR-7370-01A-11D-2129-08	4213401	91133291	64137269	603	25878											
TEX13A	56157	broad.mit.edu	37	chrX	104463830	104463830	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctgatggtctattctgtggGgccccccatcagaccacagg	7	9	11	14	0	3	2	1	1	2	1	3	2	3	2	5	4	0	0	5	4	1	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:104463830G>T	uc004ema.2	-	5	1158	c.1046C>A	c.(1045-1047)CCC>CAC	p.P349H	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.P350T	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	349						intracellular	zinc ion binding			ovary(2)	2						TATTCTGTGGGGCCCCCCATC	0.567													46	26					5.34276e-22	7.69399e-22	1	0	T	104463830	T	T	104463830	3	4	141	1	0	0	0	0	1	0	0	0	15842	1232	43	4	187	4	TEX13A	23	104463830	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	13330539	104463830	50806730	604	25879											
DCX	1641	broad.mit.edu	37	chrX	110653517	110653517	+	Frame_Shift_Del	DEL	A	-	-																															gcaaggttctggttcggtagAagctacagtgggcgctgtga																										TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:110653517delA	uc004epd.2	-	2	525	c.353delT	c.(352-354)TTCfs	p.F118fs	DCX_uc011msv.1_Frame_Shift_Del_p.F118fs|DCX_uc004epe.2_Frame_Shift_Del_p.F37fs|DCX_uc004epf.2_Frame_Shift_Del_p.F37fs|DCX_uc004epg.2_Frame_Shift_Del_p.F37fs	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	118					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						GGTTCGGTAGAAGCTACAGTG	0.512													---	---	---								-	110653517	-	-	110653517	7	5	141	1	0	1	0	1	0	0	0	0	4335	246	9	0	1011	0	DCX	23	110653517	Frame_Shift_Del	DEL	A	TCGA-CR-7370-01A-11D-2129-08	6189687	110653517	44617043	605	25880											
DCX	1641	broad.mit.edu	37	chrX	110654066	110654066	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacacatgcccacatgactaAcagttgtaaatgaatccata	16	9	5	11	0	0	2	0	2	0	0	1	2	1	2	2	0	2	2	2	0	5	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:110654066A>G	uc004epd.2	-	1	309	c.137T>C	c.(136-138)GTT>GCT	p.V46A	DCX_uc011msv.1_Missense_Mutation_p.V46A|DCX_uc004epe.2_Intron|DCX_uc004epf.2_Intron|DCX_uc004epg.2_Intron	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	46					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						CACATGACTAACAGTTGTAAA	0.428													107	64					0	0	0	0	G	110654066	G	G	110654066	3	3	141	1	0	0	0	0	1	0	0	0	4335	43	2	5	1231	5	DCX	23	110654066	Missense_Mutation	SNP	A	TCGA-CR-7370-01A-11D-2129-08	549	110654066	44616494	606	25881											
TRPC5	7224	broad.mit.edu	37	chrX	111090412	111090412	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggctcatcgatagctctggTttcataatagaagtaaagct	13	12	9	7	1	3	1	2	0	1	1	4	2	3	1	0	2	2	5	0	2	6	5			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:111090412T>A	uc004epl.1	-	6	2549	c.1630A>T	c.(1630-1632)ACC>TCC	p.T544S	TRPC5_uc004epm.1_Missense_Mutation_p.T544S	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	544	Extracellular (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						ATAGCTCTGGTTTCATAATAG	0.433													54	36					0	0	0	0	A	111090412	A	A	111090412	3	1	141	1	0	0	0	0	1	0	0	0	16649	1725	60	5	1315	5	TRPC5	23	111090412	Missense_Mutation	SNP	T	TCGA-CR-7370-01A-11D-2129-08	436346	111090412	44180148	607	25882											
ARHGAP36	158763	broad.mit.edu	37	chrX	130220339	130220339	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggcaggttgctaagcgcGtgtggaagtccagcccggaa	10	6	16	9	3	0	1	0	0	0	1	1	3	1	3	2	4	3	3	2	4	3	2			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:130220339G>T	uc004evz.2	+	10	1663	c.1318G>T	c.(1318-1320)GTG>TTG	p.V440L	ARHGAP36_uc004ewa.2_Missense_Mutation_p.V428L|ARHGAP36_uc004ewb.2_Missense_Mutation_p.V409L|ARHGAP36_uc004ewc.2_Missense_Mutation_p.V304L	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	440					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						TGCTAAGCGCGTGTGGAAGTC	0.453													27	27					2.08457e-15	2.77816e-15	1	0	T	130220339	T	T	130220339	3	4	141	1	0	0	0	0	1	0	0	0	883	1145	40	3	1352	3	ARHGAP36	23	130220339	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	19129927	130220339	25050221	608	25883											
GPR112	139378	broad.mit.edu	37	chrX	135429618	135429618	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atccagttggtgactagcacCtctgtcttatcttccgacaa	9	13	7	12	1	3	1	0	1	3	0	5	2	5	1	3	1	1	2	3	1	3	4			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:135429618C>A	uc004ezu.1	+	6	4044	c.3753C>A	c.(3751-3753)ACC>ACA	p.T1251T	GPR112_uc010nsb.1_Silent_p.T1046T|GPR112_uc010nsc.1_Silent_p.T1018T	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1251	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TGACTAGCACCTCTGTCTTAT	0.433													16	123					0.00498961	0.005144	1	0	A	135429618	A	A	135429618	2	1	141	1	0	0	0	0	0	0	0	1	6667	668	24	4		4	GPR112	23	135429618	Silent	SNP	C	TCGA-CR-7370-01A-11D-2129-08	5209279	135429618	19840942	609	25884											
GPR112	139378	broad.mit.edu	37	chrX	135431250	135431250	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aattgcttttcttctaatacTagaaagatgacttccttgtt	11	18	5	7	0	2	3	0	1	2	2	3	3	3	3	1	0	2	2	1	0	5	10			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:135431250T>G	uc004ezu.1	+	6	5676	c.5385T>G	c.(5383-5385)ACT>ACG	p.T1795T	GPR112_uc010nsb.1_Silent_p.T1590T|GPR112_uc010nsc.1_Silent_p.T1562T	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1795	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CTTCTAATACTAGAAAGATGA	0.398													31	111					0	0	0	0	G	135431250	G	G	135431250	2	3	141	1	0	0	0	0	0	0	0	1	6667	1509	53	5		5	GPR112	23	135431250	Silent	SNP	T	TCGA-CR-7370-01A-11D-2129-08	1632	135431250	19839310	610	25885											
BRS3	680	broad.mit.edu	37	chrX	135574475	135574475	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggagcatacagatgtctGaaattagtgtgacctcgttc	10	12	11	8	1	1	3	0	2	1	1	3	4	1	4	1	1	2	2	1	1	3	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:135574475G>A	uc004ezv.1	+	3	1290	c.1141G>A	c.(1141-1143)GAA>AAA	p.E381K		NM_001727	NP_001718	P32247	BRS3_HUMAN	bombesin-like receptor 3	381	Cytoplasmic (Potential).				adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					ACAGATGTCTGAAATTAGTGT	0.542													13	77					0	0	0	0	A	135574475	A	A	135574475	3	1	141	1	0	0	0	0	1	0	0	0	1527	1291	45	2	1151	2	BRS3	23	135574475	Missense_Mutation	SNP	G	TCGA-CR-7370-01A-11D-2129-08	143225	135574475	19696085	611	25886											
RAB39B	116442	broad.mit.edu	37	chrX	154493403	154493403	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagatctggagcttgatGcgttttcctggctcgatctc	5	14	10	12	2	2	2	0	1	2	1	6	4	4	3	2	2	2	3	2	2	0	3			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:154493403G>C	uc004fne.2	-	1	450	c.171C>G	c.(169-171)CGC>CGG	p.R57R		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	57				R -> T (in Ref. 1; AAL12244).	protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GGAGCTTGATGCGTTTTCCTG	0.622													34	24					0	0	0	0	C	154493403	C	C	154493403	2	2	141	1	0	0	0	0	0	0	0	1	12995	1306	46	4		4	RAB39B	23	154493403	Silent	SNP	G	TCGA-CR-7370-01A-11D-2129-08	18918928	154493403	777157	612	25887											
HSPG2	3339	broad.mit.edu	37	chr1	22157584	22157584	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatggcactgaccgccattCtgcaaagcagcccccagaag	11	6	9	15	1	2	2	1	1	1	1	2	2	2	2	4	1	3	3	4	1	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:22157584C>G	uc001bfj.2	-	85	11603	c.11563_splice	c.e85-1	p.N3855_splice	HSPG2_uc001bfi.2_5'Flank|HSPG2_uc009vqd.2_Splice_Site_p.N3856_splice	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor						angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GACCGCCATTCTGCAAAGCAG	0.637													3	18					0	0	0	0	G	22157584	G	G	22157584	5	3	142	1	0	0	0	0	0	0	1	0	7469	927	32	2	1665	2	HSPG2	1	22157584	Splice_Site	SNP	C	TCGA-CR-7371-01A-11D-2012-08		22157584	227093037	1	25888											
FNDC5	252995	broad.mit.edu	37	chr1	33330273	33330273	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttgccctcaccttgctgcGgagaagccccccgccctggt	4	9	10	18	2	2	1	1	0	1	1	2	2	2	1	6	2	4	1	6	2	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:33330273G>T	uc001bwg.2	-	5	615	c.400C>A	c.(400-402)CGC>AGC	p.R134S	FNDC5_uc001bwe.2_RNA|FNDC5_uc001bwf.1_Missense_Mutation_p.R134S	NM_153756	NP_715637	Q8NAU1	FNDC5_HUMAN	fibronectin type III domain containing 5	193	Cytoplasmic (Potential).					integral to membrane|peroxisomal membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACCTTGCTGCGGAGAAGCCCC	0.577													11	38					3.07112e-06	6.11685e-06	1	0	T	33330273	T	T	33330273	3	4	142	1	0	0	0	0	1	0	0	0	6004	1116	39	3	94	3	FNDC5	1	33330273	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	11172689	33330273	215920348	2	25889											
CSMD2	114784	broad.mit.edu	37	chr1	34092182	34092182	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccaagggcagtgattctcCtgccgagataaggggcaagg	10	6	16	9	1	1	2	0	1	1	1	2	3	1	2	3	5	1	2	3	5	3	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:34092182C>T	uc001bxn.1	-	33	5110	c.5081_splice	c.e33-1	p.G1694_splice	CSMD2_uc001bxm.1_Splice_Site_p.G1734_splice|CSMD2_uc001bxo.1_Splice_Site_p.G607_splice	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGTGATTCTCCTGCCGAGATA	0.557													5	11					0	0	0	0	T	34092182	T	T	34092182	5	4	142	1	0	0	0	0	0	0	1	0	3962	695	24	4	5531	4	CSMD2	1	34092182	Splice_Site	SNP	C	TCGA-CR-7371-01A-11D-2012-08	761909	34092182	215158439	3	25890											
ZMYM1	79830	broad.mit.edu	37	chr1	35580175	35580175	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctttaaaacaatctgggatgGaacagaggaaatatgtcaaa	18	9	9	5	0	2	1	1	0	1	1	2	4	2	4	0	3	2	0	0	3	7	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:35580175G>C	uc001bym.2	+	11	2892	c.2744G>C	c.(2743-2745)GGA>GCA	p.G915A	ZMYM1_uc001byn.2_Missense_Mutation_p.G915A|ZMYM1_uc010ohu.1_Missense_Mutation_p.G896A|ZMYM1_uc001byo.2_Missense_Mutation_p.G555A|ZMYM1_uc009vut.2_Missense_Mutation_p.G840A	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	915						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATCTGGGATGGAACAGAGGAA	0.294													4	19					0	0	0	0	C	35580175	C	C	35580175	3	2	142	1	0	0	0	0	1	0	0	0	17766	1174	41	2	2778	2	ZMYM1	1	35580175	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1487993	35580175	213670446	4	25891											
ZSWIM5	57643	broad.mit.edu	37	chr1	45516821	45516821	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccatagtttccatcctccaGgggacagacatccaggtcgc	9	9	9	14	1	0	1	0	0	0	1	6	2	5	2	5	3	0	1	5	3	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:45516821G>C	uc001cnd.2	-	5	1585	c.1357C>G	c.(1357-1359)CTG>GTG	p.L453V		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	453							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					CCATCCTCCAGGGGACAGACA	0.517													35	56					0	0	0	0	C	45516821	C	C	45516821	3	2	142	1	0	0	0	0	1	0	0	0	18311	991	35	4	2240	4	ZSWIM5	1	45516821	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	9936646	45516821	203733800	5	25892											
ACOT11	26027	broad.mit.edu	37	chr1	55059688	55059688	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcaaggccttggccaccttCgtggcccgccgagagatcac	7	7	12	15	3	1	1	1	0	0	1	2	3	1	1	5	3	1	1	5	3	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:55059688C>T	uc001cxm.1	+	5	529	c.447C>T	c.(445-447)TTC>TTT	p.F149F	ACOT11_uc001cxj.1_Silent_p.F27F|ACOT11_uc001cxk.2_Silent_p.F115F|ACOT11_uc001cxl.1_Silent_p.F149F	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	149	Acyl coenzyme A hydrolase 1.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						TGGCCACCTTCGTGGCCCGCC	0.632													8	49					0	0	0	0	T	55059688	T	T	55059688	2	4	142	1	0	0	0	0	0	0	0	1	149	883	31	1		1	ACOT11	1	55059688	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	9542867	55059688	194190933	6	25893											
DPYD	1806	broad.mit.edu	37	chr1	98015229	98015229	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaatacccatgcttcactagTttgcatagtttctggatcta	11	15	6	9	0	3	0	1	0	2	0	3	1	3	1	1	1	3	4	1	1	5	7			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:98015229T>A	uc001drv.2	-	12	1548	c.1411A>T	c.(1411-1413)ACT>TCT	p.T471S		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	471	FAD (Potential).				'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GCTTCACTAGTTTGCATAGTT	0.403													10	21					0	0	0	0	A	98015229	A	A	98015229	3	1	142	1	0	0	0	0	1	0	0	0	4767	1725	60	5	1714	5	DPYD	1	98015229	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	42955541	98015229	151235392	7	25894											
SYPL2	284612	broad.mit.edu	37	chr1	110020605	110020605	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtgccggggccacgcccTctatgggcctggccaacatc	6	6	13	16	2	1	0	0	0	1	0	2	0	1	0	5	4	2	1	5	4	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:110020605T>A	uc001dxp.2	+	5	988	c.622T>A	c.(622-624)TCT>ACT	p.S208T	SYPL2_uc001dxo.2_Missense_Mutation_p.S208T|SYPL2_uc010ovk.1_Intron|SYPL2_uc001dxq.2_Missense_Mutation_p.S116T	NM_001040709	NP_001035799	Q5VXT5	SYPL2_HUMAN	mitsugumin 29	208	Vesicular (Potential).|MARVEL.					integral to membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGCCACGCCCTCTATGGGCCT	0.637													9	29					0	0	0	0	A	110020605	A	A	110020605	3	1	142	1	0	0	0	0	1	0	0	0	15529	1551	54	5	640	5	SYPL2	1	110020605	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	12005376	110020605	139230016	8	25895											
TRIM45	80263	broad.mit.edu	37	chr1	117656090	117656090	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggtgctttctcctcaccatCacagtgaatggcgagccctg	7	10	10	14	2	3	1	2	1	1	0	4	2	3	1	3	2	2	1	3	2	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:117656090C>G	uc001egz.2	-	5	2073	c.1485G>C	c.(1483-1485)GTG>GTC	p.V495V	TRIM45_uc009whe.2_Silent_p.V477V|TRIM45_uc001eha.2_Silent_p.V391V	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	495	Filamin.					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		TCCTCACCATCACAGTGAATG	0.552													8	14					0	0	0	0	G	117656090	G	G	117656090	2	3	142	1	0	0	0	0	0	0	0	1	16587	813	29	2		2	TRIM45	1	117656090	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	7635485	117656090	131594531	9	25896											
FLG	2312	broad.mit.edu	37	chr1	152279054	152279054	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtgcctggagctgtcttgtgCctgctcatggcgggatcctt	3	13	14	11	1	2	0	1	0	1	0	3	2	3	2	3	3	4	2	3	3	0	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:152279054C>T	uc001ezu.1	-	3	8344	c.8308G>A	c.(8308-8310)GCA>ACA	p.A2770T		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2770	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCTTGTGCCTGCTCATGG	0.587									Ichthyosis				15	588					0	0	0	0	T	152279054	T	T	152279054	3	4	142	1	0	0	0	0	1	0	0	0	5954	739	26	4	3881	4	FLG	1	152279054	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	34622964	152279054	96971567	10	25897											
FLG	2312	broad.mit.edu	37	chr1	152283044	152283044	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcacctggtagaggaaagAccttgaacgtccagagcttt	11	9	11	10	1	1	4	1	1	0	3	2	5	2	5	3	2	2	3	3	2	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:152283044A>G	uc001ezu.1	-	3	4354	c.4318T>C	c.(4318-4320)TCT>CCT	p.S1440P	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1440	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAGAGGAAAGACCTTGAACGT	0.587									Ichthyosis				15	273					0	0	0	0	G	152283044	G	G	152283044	3	3	142	1	0	0	0	0	1	0	0	0	5954	275	10	5	7871	5	FLG	1	152283044	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	3990	152283044	96967577	11	25898											
CLK2	1196	broad.mit.edu	37	chr1	155240769	155240769	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccttcgaggatgcggcatCtggaaggcaagggaaagcgg	11	6	16	8	3	1	0	0	0	1	0	2	4	1	3	1	6	3	2	1	6	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:155240769C>G	uc001fjy.2	-	2	291	c.1_splice	c.e2-1	p.M1_splice	RAG1AP1_uc010pey.1_Intron|CLK2_uc001fjw.2_Splice_Site_p.M1_splice|CLK2_uc001fjx.2_Splice_Site|CLK2_uc009wqm.2_Splice_Site_p.M1_splice	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2							nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GATGCGGCATCTGGAAGGCAA	0.527								Other_conserved_DNA_damage_response_genes					16	144					0	0	0	0	G	155240769	G	G	155240769	5	3	142	1	0	0	0	0	0	0	1	0	3552	927	32	2	1544	2	CLK2	1	155240769	Splice_Site	SNP	C	TCGA-CR-7371-01A-11D-2012-08	2957725	155240769	94009852	12	25899											
BCAN	63827	broad.mit.edu	37	chr1	156621474	156621474	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagcagaggcccctaggacGctcctaggtaagtcggatcc	9	6	12	14	2	0	1	0	0	0	1	3	3	2	3	5	4	1	3	5	4	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:156621474G>A	uc001fpp.2	+	7	1626	c.1290G>A	c.(1288-1290)ACG>ACA	p.T430T	BCAN_uc001fpo.2_Silent_p.T430T	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	430	Glu-rich.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCCCTAGGACGCTCCTAGGTA	0.557													16	80					0	0	0	0	A	156621474	A	A	156621474	2	1	142	1	0	0	0	0	0	0	0	1	1347	1074	38	1		1	BCAN	1	156621474	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1380705	156621474	92629147	13	25900											
NTRK1	4914	broad.mit.edu	37	chr1	156849868	156849868	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtaagttcaccaccgagagCgacgtgtggagcttcggcgt	8	8	14	11	6	1	1	1	0	0	1	2	4	1	2	2	2	2	3	2	2	1	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:156849868C>T	uc001fqh.1	+	16	2180	c.2124C>T	c.(2122-2124)AGC>AGT	p.S708S	NTRK1_uc001fqf.1_Silent_p.S672S|NTRK1_uc009wsi.1_Silent_p.S407S|NTRK1_uc001fqi.1_Silent_p.S702S|NTRK1_uc009wsk.1_Silent_p.S705S	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	708	Cytoplasmic (Potential).|Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CCACCGAGAGCGACGTGTGGA	0.647			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			5	82					0	0	0	0	T	156849868	T	T	156849868	2	4	142	1	0	0	0	0	0	0	0	1	10760	767	27	1		1	NTRK1	1	156849868	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	228394	156849868	92400753	14	25901											
FCRL3	115352	broad.mit.edu	37	chr1	157667698	157667698	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacaggatgtaaagcctgcaGgatcagccagtctgcaaaga	14	6	12	9	0	2	1	1	0	1	1	2	4	2	3	2	2	4	3	2	2	3	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:157667698G>T	uc001frb.2	-	5	602	c.310C>A	c.(310-312)CTG>ATG	p.L104M	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.L104M|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Translation_Start_Site|FCRL3_uc001frc.1_Missense_Mutation_p.L104M	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	104	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					AAAGCCTGCAGGATCAGCCAG	0.468													7	27					8.12818e-05	0.000156711	1	0	T	157667698	T	T	157667698	3	4	142	1	0	0	0	0	1	0	0	0	5828	991	35	4	1938	4	FCRL3	1	157667698	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	817830	157667698	91582923	15	25902											
SPTA1	6708	broad.mit.edu	37	chr1	158595971	158595971	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaggaagtcaccaaggtCtgcaccattgccattggtct	10	10	11	10	0	3	1	1	1	2	0	3	2	3	2	3	3	2	1	3	3	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:158595971C>A	uc001fst.1	-	42	6074	c.5875G>T	c.(5875-5877)GAC>TAC	p.D1959Y		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1959	Spectrin 19.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCACCAAGGTCTGCACCATTG	0.423													8	34					1.12685e-05	2.23209e-05	1	0	A	158595971	A	A	158595971	3	1	142	1	0	0	0	0	1	0	0	0	15182	913	32	2	1428	2	SPTA1	1	158595971	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	928273	158595971	90654650	16	25903											
OR6K6	128371	broad.mit.edu	37	chr1	158724934	158724934	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccaccatccccaagatgcTgtcctgcctaatcagtgagc	11	8	7	15	0	1	2	1	1	0	1	3	2	3	2	6	0	4	1	6	0	3	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:158724934T>G	uc001fsw.1	+	1	329	c.329T>G	c.(328-330)CTG>CGG	p.L110R		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	110	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					CCCAAGATGCTGTCCTGCCTA	0.512													35	113					0	0	0	0	G	158724934	G	G	158724934	3	3	142	1	0	0	0	0	1	0	0	0	11258	1580	55	5	331	5	OR6K6	1	158724934	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	128963	158724934	90525687	17	25904											
IFI16	3428	broad.mit.edu	37	chr1	159021690	159021690	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagttcaccccaaagaagatCattgccatagcaaattatgt	16	10	6	9	0	2	2	2	0	0	2	2	2	2	2	3	0	2	2	3	0	6	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:159021690C>G	uc001ftg.2	+	9	2009	c.1719C>G	c.(1717-1719)ATC>ATG	p.I573M	IFI16_uc010pis.1_Missense_Mutation_p.I573M|IFI16_uc001fth.2_Missense_Mutation_p.I116M|IFI16_uc010pit.1_Missense_Mutation_p.I172M	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	629	HIN-200 2.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					CAAAGAAGATCATTGCCATAG	0.423													13	59					0	0	0	0	G	159021690	G	G	159021690	3	3	142	1	0	0	0	0	1	0	0	0	7550	816	29	2	1749	2	IFI16	1	159021690	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	296756	159021690	90228931	18	25905											
CASQ1	844	broad.mit.edu	37	chr1	160160609	160160609	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggcactgctgttgctgcTggtgctagggacacccaagt	6	10	14	11	0	0	0	0	0	0	0	0	1	0	1	1	3	4	7	1	3	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:160160609T>A	uc010pja.1	+	1	325	c.68T>A	c.(67-69)CTG>CAG	p.L23Q		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	23	Poly-Leu.					mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTGTTGCTGCTGGTGCTAGGG	0.592													9	38					0	0	0	0	A	160160609	A	A	160160609	3	1	142	1	0	0	0	0	1	0	0	0	2692	1580	55	5	70	5	CASQ1	1	160160609	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	1138919	160160609	89090012	19	25906											
DCAF8	50717	broad.mit.edu	37	chr1	160209906	160209906	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcttcttcctcctcttcctCttcctctgagcggtcatgga	3	16	6	16	1	6	1	1	1	5	0	10	2	10	2	4	2	1	0	4	2	0	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:160209906C>G	uc001fvo.2	-	4	616	c.304G>C	c.(304-306)GAG>CAG	p.E102Q	DCAF8_uc001fvn.2_Missense_Mutation_p.E102Q|DCAF8_uc009wth.2_Missense_Mutation_p.E102Q|DCAF8_uc010pjb.1_Missense_Mutation_p.E102Q|DCAF8_uc010pjc.1_Missense_Mutation_p.E256Q|DCAF8_uc001fvq.3_Missense_Mutation_p.E102Q|DCAF8_uc001fvp.3_Missense_Mutation_p.E102Q|uc010pjd.1_3'UTR	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	102						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						tcctcttcctcttcctctGAG	0.438													3	28					0	0	0	0	G	160209906	G	G	160209906	3	3	142	1	0	0	0	0	1	0	0	0	4293	922	32	2	1533	2	DCAF8	1	160209906	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	49297	160209906	89040715	20	25907											
F5	2153	broad.mit.edu	37	chr1	169511663	169511664	+	Nonsense_Mutation	DNP	TA	AT	AT																															gcttaggtgtctcccaacttTatgtgctagtaatttcatcc																										TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:169511663_169511664TA>AT	uc001ggg.1	-	13	2809_2810	c.2664_2665TA>AT	c.(2662-2667)CATAAA>CAATAA	p.888_889HK>Q*		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	888_889	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CTCCCAACTTTATGTGCTAGTA	0.475													32	133					0	0	0	0	AT	169511664	AT	AT	169511663	4	1	142	1	0	0	0	0	0	1	0	0	5373	1763	61	5	4061	5	F5	1	169511663	Nonsense_Mutation	DNP	TA	TCGA-CR-7371-01A-11D-2012-08	9301757	169511663	79738958	21	25908											
TNN	63923	broad.mit.edu	37	chr1	175086104	175086104	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccccaaaacctggtgaccGaccgggtgacagagaatatg	12	5	12	12	2	0	3	0	2	0	1	0	5	0	3	5	2	1	0	5	2	4	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:175086104G>T	uc001gkl.1	+	10	2262	c.2149G>T	c.(2149-2151)GAC>TAC	p.D717Y		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	717	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCTGGTGACCGACCGGGTGAC	0.512													25	119					2.44723e-14	5.51199e-14	1	0	T	175086104	T	T	175086104	3	4	142	1	0	0	0	0	1	0	0	0	16389	1058	37	3	2183	3	TNN	1	175086104	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	5574441	175086104	74164517	22	25909											
PAPPA2	60676	broad.mit.edu	37	chr1	176525600	176525600	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaggtgctgttggaaggaGaacgttgttggctgggggcc	7	10	18	6	1	1	1	1	0	0	1	1	3	1	2	1	6	2	5	1	6	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:176525600G>C	uc001gkz.2	+	2	1306	c.142G>C	c.(142-144)GAA>CAA	p.E48Q	PAPPA2_uc001gky.1_Missense_Mutation_p.E48Q|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	48					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GTTGGAAGGAGAACGTTGTTG	0.572													17	98					0	0	0	0	C	176525600	C	C	176525600	3	2	142	1	0	0	0	0	1	0	0	0	11487	943	33	2	144	2	PAPPA2	1	176525600	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1439496	176525600	72725021	23	25910											
IER5	51278	broad.mit.edu	37	chr1	181058479	181058479	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagccgcgtggaggggccGcgccaggcggcggccagaga	6	2	21	12	6	0	1	0	0	0	1	0	4	0	3	4	7	1	0	4	7	0	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:181058479G>C	uc001got.3	+	1	842	c.441G>C	c.(439-441)CCG>CCC	p.P147P		NM_016545	NP_057629	Q5VY09	IER5_HUMAN	immediate early response 5	147										pancreas(1)	1						TGGAGGGGCCGCGCCAGGCGG	0.746													3	9					0	0	0	0	C	181058479	C	C	181058479	2	2	142	1	0	0	0	0	0	0	0	1	7547	1074	38	3		3	IER5	1	181058479	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	4532879	181058479	68192142	24	25911											
CFHR2	3080	broad.mit.edu	37	chr1	196920114	196920114	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgagaacaacatttcatGtgtagaacggggctggtcca	13	9	11	8	1	1	2	1	1	0	2	2	3	2	2	1	3	3	2	1	3	5	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:196920114G>T	uc001gtq.1	+	3	463	c.386G>T	c.(385-387)TGT>TTT	p.C129F	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	129	Sushi 2.					extracellular region				skin(2)|ovary(1)	3						AACATTTCATGTGTAGAACGG	0.383													7	51					0.00448238	0.00826725	1	0	T	196920114	T	T	196920114	3	4	142	1	0	0	0	0	1	0	0	0	3300	1377	48	4	396	4	CFHR2	1	196920114	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	15861635	196920114	52330507	25	25912											
CRB1	23418	broad.mit.edu	37	chr1	197403914	197403914	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaatattaccagagaactcaCcaatatcacatttggtttca	15	12	5	9	0	3	1	3	0	0	1	3	3	3	1	2	1	2	1	2	1	6	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:197403914C>A	uc001gtz.2	+	9	3056	c.2921C>A	c.(2920-2922)ACC>AAC	p.T974N	CRB1_uc010poz.1_Missense_Mutation_p.T950N|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.T862N|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.T455N|CRB1_uc001gub.1_Missense_Mutation_p.T623N	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	974	Extracellular (Potential).|Laminin G-like 3.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AGAGAACTCACCAATATCACA	0.333													8	42					0.00307968	0.00569465	1	0	A	197403914	A	A	197403914	3	1	142	1	0	0	0	0	1	0	0	0	3863	507	18	4	2955	4	CRB1	1	197403914	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	483800	197403914	51846707	26	25913											
PROX1	5629	broad.mit.edu	37	chr1	214170122	214170122	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagggcgaactcgtatgaaGatgccatgatgccttttcca	11	10	11	9	2	0	4	0	2	0	2	2	5	1	4	3	1	3	1	3	1	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:214170122G>C	uc001hkh.2	+	2	516	c.244G>C	c.(244-246)GAT>CAT	p.D82H	PROX1_uc001hkg.1_Missense_Mutation_p.D82H	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	82					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CTCGTATGAAGATGCCATGAT	0.483													4	83					0	0	0	0	C	214170122	C	C	214170122	3	2	142	1	0	0	0	0	1	0	0	0	12622	942	33	2	246	2	PROX1	1	214170122	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	16766208	214170122	35080499	27	25914											
USH2A	7399	broad.mit.edu	37	chr1	215821936	215821936	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccgtccttgaggccagcGtcccgatttgtggagaggac	7	8	15	11	3	0	2	0	1	0	1	2	5	2	3	4	4	1	0	4	4	0	2	rs139065588		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:215821936G>A	uc001hku.1	-	66	14903	c.14516C>T	c.(14515-14517)ACG>ATG	p.T4839M		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4839	Extracellular (Potential).|Fibronectin type-III 34.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGAGGCCAGCGTCCCGATTTG	0.572										HNSCC(13;0.011)			23	65					0	0	0	0	A	215821936	A	A	215821936	3	1	142	1	0	0	0	0	1	0	0	0	17104	1145	40	1	1120	1	USH2A	1	215821936	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1651814	215821936	33428685	28	25915											
TTC13	79573	broad.mit.edu	37	chr1	231076226	231076226	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccccgatgtctgtacagcCgtgctgagggctgcagttgg	5	11	14	11	2	1	1	0	1	1	0	2	2	2	1	3	2	4	5	3	2	1	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:231076226C>A	uc001huf.3	-	7	780	c.749G>T	c.(748-750)CGG>CTG	p.R250L	TTC13_uc009xfi.2_Missense_Mutation_p.R197L|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.R197L|TTC13_uc009xfk.1_Missense_Mutation_p.R140L	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	250	TPR 3.						binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TCTGTACAGCCGTGCTGAGGG	0.423													7	35					0.00198382	0.00369665	1	0	A	231076226	A	A	231076226	3	1	142	1	0	0	0	0	1	0	0	0	16748	652	23	3	1901	3	TTC13	1	231076226	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	15254290	231076226	18174395	29	25916											
ACTN2	88	broad.mit.edu	37	chr1	236900470	236900470	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggttcttgctgtgaatcaaGagaatgagaggctgatggaa	13	10	14	4	0	2	4	1	3	1	2	2	7	2	5	0	3	1	3	0	3	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:236900470G>C	uc001hyf.2	+	9	1036	c.832G>C	c.(832-834)GAG>CAG	p.E278Q	ACTN2_uc001hyg.2_Missense_Mutation_p.E70Q|ACTN2_uc009xgi.1_Missense_Mutation_p.E278Q|ACTN2_uc010pxu.1_Missense_Mutation_p.E63Q|ACTN2_uc001hyh.2_5'Flank	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	278					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TGTGAATCAAGAGAATGAGAG	0.512													7	45					0	0	0	0	C	236900470	C	C	236900470	3	2	142	1	0	0	0	0	1	0	0	0	205	943	33	2	866	2	ACTN2	1	236900470	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	5824244	236900470	12350151	30	25917											
MTR	4548	broad.mit.edu	37	chr1	236979822	236979822	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagggatttgtcatcagcgTgtctcatggagaaccactct	10	11	11	9	1	4	2	3	0	2	2	5	4	4	3	1	2	2	0	1	2	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:236979822T>A	uc001hyi.3	+	8	1166	c.743T>A	c.(742-744)GTG>GAG	p.V248E	MTR_uc010pxv.1_RNA|MTR_uc010pxw.1_5'UTR|MTR_uc010pxx.1_Missense_Mutation_p.V248E|MTR_uc010pxy.1_Missense_Mutation_p.V248E|MTR_uc009xgj.1_Missense_Mutation_p.C79S	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	248	Hcy-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GTCATCAGCGTGTCTCATGGA	0.458													26	101					0	0	0	0	A	236979822	A	A	236979822	3	1	142	1	0	0	0	0	1	0	0	0	10011	1696	59	5	773	5	MTR	1	236979822	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	79352	236979822	12270799	31	25918											
WDR64	128025	broad.mit.edu	37	chr1	241953918	241953918	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaaaatgagctcagtgtctCtacttttcaaacgcacacct	13	11	6	11	1	3	1	2	1	1	0	4	2	3	1	1	0	3	2	1	0	4	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr1:241953918C>G	uc001hzf.1	+	14	1699	c.1546C>G	c.(1546-1548)CTA>GTA	p.L516V	WDR64_uc001hzg.1_Missense_Mutation_p.L429V	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	963										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CTCAGTGTCTCTACTTTTCAA	0.353													26	84					0	0	0	0	G	241953918	G	G	241953918	3	3	142	1	0	0	0	0	1	0	0	0	17383	912	32	2	2981	2	WDR64	1	241953918	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	4974096	241953918	7296703	32	25919											
PXDN	7837	broad.mit.edu	37	chr2	1664703	1664703	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccgacccaatggtgttccggGccacacactcatagcgacct	9	7	9	16	3	1	0	1	0	0	0	2	2	2	0	5	2	1	1	5	2	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:1664703G>C	uc002qxa.2	-	14	1851	c.1787C>G	c.(1786-1788)GCC>GGC	p.A596G	PXDN_uc002qxb.1_Missense_Mutation_p.A596G	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	596	Ig-like C2-type 4.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GGTGTTCCGGGCCACACACTC	0.522													5	57					0	0	0	0	C	1664703	C	C	1664703	3	2	142	1	0	0	0	0	1	0	0	0	12912	1203	42	4	2692	4	PXDN	2	1664703	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08		1664703	241534670	33	25920											
ADCY3	109	broad.mit.edu	37	chr2	25050956	25050956	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagttgtaatacttggggttCtccaggcagctgccctccgt	6	13	11	11	1	1	0	0	0	1	0	3	0	2	0	3	3	3	5	3	3	3	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:25050956C>T	uc002rfs.3	-	13	2446	c.2247G>A	c.(2245-2247)GAG>GAA	p.E749E	ADCY3_uc002rfr.3_Intron|ADCY3_uc010ykm.1_Silent_p.E749E	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	749					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					ACTTGGGGTTCTCCAGGCAGC	0.607											OREG0014498	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	36					0	0	0	0	T	25050956	T	T	25050956	2	4	142	1	0	0	0	0	0	0	0	1	295	912	32	2		2	ADCY3	2	25050956	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	23386253	25050956	218148417	34	25921											
MAPRE3	22924	broad.mit.edu	37	chr2	27247054	27247054	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattctttgacgcaaactatGatggaaaggattacaaccct	15	11	7	8	1	1	2	0	2	1	0	1	4	1	4	1	2	3	1	1	2	6	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:27247054G>C	uc002rhw.2	+	4	511	c.358G>C	c.(358-360)GAT>CAT	p.D120H	MAPRE3_uc002rhx.2_Missense_Mutation_p.D120H	NM_012326	NP_036458	Q9UPY8	MARE3_HUMAN	microtubule-associated protein, RP/EB family,	120					cell division|mitosis|positive regulation of transcription, DNA-dependent	cytoplasm|cytoplasmic microtubule|microtubule|midbody|perinuclear region of cytoplasm	microtubule binding|protein binding|small GTPase regulator activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGCAAACTATGATGGAAAGGA	0.413													7	34					0	0	0	0	C	27247054	C	C	27247054	3	2	142	1	0	0	0	0	1	0	0	0	9349	1290	45	2	368	2	MAPRE3	2	27247054	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	2196098	27247054	215952319	35	25922											
BIRC6	57448	broad.mit.edu	37	chr2	32667279	32667279	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggttagctggagttcattCaaatggacccggaaggttaa	11	12	12	6	1	2	0	2	0	0	0	2	3	2	3	1	5	1	4	1	5	4	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:32667279C>T	uc010ezu.2	+	18	4225	c.4091C>T	c.(4090-4092)TCA>TTA	p.S1364L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1364					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GGAGTTCATTCAAATGGACCC	0.388													6	43					0	0	0	0	T	32667279	T	T	32667279	3	4	142	1	0	0	0	0	1	0	0	0	1441	838	29	2	4161	2	BIRC6	2	32667279	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	5420225	32667279	210532094	36	25923											
HEATR5B	54497	broad.mit.edu	37	chr2	37217854	37217854	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cagccattctgtaatgactgGactcctattatttcattact	10	16	5	10	0	2	1	1	1	1	0	3	2	3	2	2	1	2	1	2	1	4	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:37217854G>C	uc002rpp.1	-	34	5730	c.5634C>G	c.(5632-5634)GTC>GTG	p.V1878V	HEATR5B_uc002rpo.1_Silent_p.V190V|HEATR5B_uc010ezy.1_Silent_p.V373V	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1878							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				GTAATGACTGGACTCCTATTA	0.373													10	47					0	0	0	0	C	37217854	C	C	37217854	2	2	142	1	0	0	0	0	0	0	0	1	7071	1161	41	2		2	HEATR5B	2	37217854	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	4550575	37217854	205981519	37	25924											
C2orf78	388960	broad.mit.edu	37	chr2	74041177	74041177	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cacactggggcctcaactatCctgcctgcaatcttatggct	8	11	8	14	0	2	0	1	0	1	0	3	0	3	0	3	3	3	2	3	3	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:74041177C>G	uc002sjr.1	+	2	792	c.671C>G	c.(670-672)TCC>TGC	p.S224C		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	224										ovary(2)	2						CCTCAACTATCCTGCCTGCAA	0.483													18	74					0	0	0	0	G	74041177	G	G	74041177	3	3	142	1	0	0	0	0	1	0	0	0	2205	855	30	2	677	2	C2orf78	2	74041177	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	36823323	74041177	169158196	38	25925											
CTNNA2	1496	broad.mit.edu	37	chr2	80097015	80097016	+	Missense_Mutation	DNP	GG	TT	TT																															aaaccgttttaaagagtttgGgaaagagatggtgaaactta																										TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:80097015_80097016GG>TT	uc010ysh.1	+	4	544_545	c.539_540GG>TT	c.(538-540)GGG>GTT	p.G180V	CTNNA2_uc010yse.1_Missense_Mutation_p.G180V|CTNNA2_uc010ysf.1_Missense_Mutation_p.G180V|CTNNA2_uc010ysg.1_Missense_Mutation_p.G180V	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	180					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AAAGAGTTTGGGAAAGAGATGG	0.401													8	52					0	0	0	0	TT	80097016	TT	TT	80097015	3	4	142	1	0	0	0	0	1	0	0	0	4030	1232	43	4	553	4	CTNNA2	2	80097015	Missense_Mutation	DNP	GG	TCGA-CR-7371-01A-11D-2012-08	6055838	80097015	163102358	39	25926											
LRRTM1	347730	broad.mit.edu	37	chr2	80530635	80530635	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaaggcgtccccctgcaCggagcagatgtgattgtgat	9	9	13	10	2	0	4	0	3	0	1	1	5	1	5	2	2	2	2	2	2	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:80530635C>G	uc002sok.1	-	2	580	c.310G>C	c.(310-312)GTG>CTG	p.V104L	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	104	LRR 1.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						TCCCCCTGCACGGAGCAGATG	0.597										HNSCC(69;0.2)			22	110					0	0	0	0	G	80530635	G	G	80530635	3	3	142	1	0	0	0	0	1	0	0	0	9089	536	19	3	1262	3	LRRTM1	2	80530635	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	433620	80530635	162668738	40	25927											
GPAT2	150763	broad.mit.edu	37	chr2	96689186	96689186	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caggctggccgggagcctggGgtctaggggccgtggagcca	5	5	20	11	2	1	0	0	0	1	0	1	2	1	2	4	8	2	1	4	8	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:96689186G>A	uc002svf.2	-	18	2122	c.1899C>T	c.(1897-1899)ACC>ACT	p.T633T	GPAT2_uc002svd.2_Silent_p.T452T|GPAT2_uc002sve.2_Silent_p.T435T|GPAT2_uc002svg.2_Silent_p.T512T|GPAT2_uc010yuh.1_Silent_p.T562T|GPAT2_uc002svh.2_Intron	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	633					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						GGGAGCCTGGGGTCTAGGGGC	0.567													10	41					0	0	0	0	A	96689186	A	A	96689186	2	1	142	1	0	0	0	0	0	0	0	1	6627	1219	43	4		4	GPAT2	2	96689186	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	16158551	96689186	146510187	41	25928											
KYNU	8942	broad.mit.edu	37	chr2	143712377	143712377	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacgatatgtttattttacAggagccaatgagaaagaaat	16	13	8	4	1	0	2	0	1	0	2	0	5	0	3	1	1	3	1	1	1	7	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:143712377A>G	uc002tvl.2	+	5	504	c.374_splice	c.e5-2	p.G125_splice	KYNU_uc002tvk.2_Splice_Site_p.G125_splice|KYNU_uc010fnm.2_Splice_Site_p.G125_splice	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a						anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTTATTTTACAGGAGCCAATG	0.303													11	27					0	0	0	0	G	143712377	G	G	143712377	5	3	142	1	0	0	0	0	0	0	1	0	8627	202	7	5	386	5	KYNU	2	143712377	Splice_Site	SNP	A	TCGA-CR-7371-01A-11D-2012-08	47023191	143712377	99486996	42	25929											
ATP5G3	518	broad.mit.edu	37	chr2	176043799	176043799	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattacctggcataaccaatGataaggctgccaaagactgt	14	9	9	9	0	0	2	0	1	0	1	0	3	0	2	3	2	3	2	3	2	5	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:176043799G>C	uc002ujz.3	-	3	570	c.300C>G	c.(298-300)ATC>ATG	p.I100M	ATP5G3_uc002uka.3_Missense_Mutation_p.I100M|ATP5G3_uc002ukb.1_Missense_Mutation_p.I100M	NM_001002258	NP_001002258	P48201	AT5G3_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	100	Helical; (Potential).				ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.147)			CATAACCAATGATAAGGCTGC	0.388													11	42					0	0	0	0	C	176043799	C	C	176043799	3	2	142	1	0	0	0	0	1	0	0	0	1157	1280	45	2	140	2	ATP5G3	2	176043799	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	32331422	176043799	67155574	43	25930											
OSBPL6	114880	broad.mit.edu	37	chr2	179259094	179259094	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagagaagcaaagagtagaGgaactccagagatctcggag	16	5	13	7	1	2	4	1	0	1	4	4	8	3	6	1	2	2	2	1	2	4	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:179259094G>A	uc002ulx.2	+	24	3006	c.2628G>A	c.(2626-2628)GAG>GAA	p.E876E	OSBPL6_uc002uly.2_Silent_p.E901E|OSBPL6_uc010zfe.1_Silent_p.E845E|OSBPL6_uc002ulz.2_Silent_p.E840E|OSBPL6_uc002uma.2_Silent_p.E880E	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	876					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			AAAGAGTAGAGGAACTCCAGA	0.348													22	66					0	0	0	0	A	179259094	A	A	179259094	2	1	142	1	0	0	0	0	0	0	0	1	11335	991	35	4		4	OSBPL6	2	179259094	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	3215295	179259094	63940279	44	25931											
TTN	7273	broad.mit.edu	37	chr2	179579978	179579978	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ataggatgaggctttttgcgGaaaatgggtggttctaaaat	12	13	13	3	1	1	1	0	1	1	0	1	3	1	3	0	5	1	2	0	5	5	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:179579978G>A	uc010zfg.1	-	87	22427	c.22203C>T	c.(22201-22203)TTC>TTT	p.F7401F	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.F4062F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8328							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTTTTGCGGAAAATGGGTG	0.388													19	43					0	0	0	0	A	179579978	A	A	179579978	2	1	142	1	0	0	0	0	0	0	0	1	16803	1165	41	2		2	TTN	2	179579978	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	320884	179579978	63619395	45	25932											
FRZB	2487	broad.mit.edu	37	chr2	183731215	183731215	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgggcacccggagcaggcaGagagcagccagggcaagcag	11	0	17	13	2	0	1	0	0	0	1	0	3	0	2	3	4	4	6	3	4	1	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:183731215G>A	uc002upa.1	-	1	284	c.66C>T	c.(64-66)CTC>CTT	p.L22L		NM_001463	NP_001454	Q92765	SFRP3_HUMAN	frizzled-related protein precursor	22					brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			GGAGCAGGCAGAGAGCAGCCA	0.706													4	5					0	0	0	0	A	183731215	A	A	183731215	2	1	142	1	0	0	0	0	0	0	0	1	6099	929	33	2		2	FRZB	2	183731215	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	4151237	183731215	59468158	46	25933											
CFLAR	8837	broad.mit.edu	37	chr2	202005138	202005138	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagcaatccaaaagagtctCaaggatccttcaaataactt	16	9	6	10	0	2	1	2	0	1	1	5	2	4	2	2	1	2	2	2	1	6	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:202005138C>T	uc002uxb.3	+	5	1034	c.582C>T	c.(580-582)CTC>CTT	p.L194L	CFLAR_uc002uwz.2_Silent_p.L194L|CFLAR_uc002uxa.3_Silent_p.L194L|CFLAR_uc010zhk.1_Silent_p.L98L|CFLAR_uc002uxc.3_Silent_p.L194L|CFLAR_uc010zhl.1_Silent_p.L98L|CFLAR_uc010fsw.1_RNA|CFLAR_uc002uxd.3_Silent_p.L194L|CFLAR_uc002uxe.2_Silent_p.L194L|CFLAR_uc002uxf.2_Silent_p.L194L|CFLAR_uc010fsy.2_RNA|CFLAR_uc010fsx.2_Silent_p.L194L|CFLAR_uc010zhm.1_Silent_p.L98L|CFLAR_uc010fsz.2_5'UTR|CFLAR_uc002uxg.2_5'UTR|uc002uxh.1_RNA	NM_003879	NP_003870	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator isoform	194	Interaction with caspase-8 propeptide.|Interaction with FADD.|Interaction with caspase-3.|Not proteolytically processed and involved in apoptosis inhibition.|Interaction with TRAF1 and TRAF2.|Interaction with caspase-8.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding				0						AAAAGAGTCTCAAGGATCCTT	0.388													13	38					0	0	0	0	T	202005138	T	T	202005138	2	4	142	1	0	0	0	0	0	0	0	1	3307	813	29	2		2	CFLAR	2	202005138	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	18273923	202005138	41194235	47	25934											
ING5	84289	broad.mit.edu	37	chr2	242662623	242662623	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttctccctttactttgcAgtgtccaattgagtggtttc	5	18	9	9	0	1	1	0	1	1	0	4	1	2	1	2	2	2	3	2	2	2	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr2:242662623A>T	uc002wcd.2	+	7	644	c.619_splice	c.e7-2	p.C207_splice		NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5						DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		TTTACTTTGCAGTGTCCAATT	0.522													57	191					0	0	0	0	T	242662623	T	T	242662623	5	4	142	1	0	0	0	0	0	0	1	0	7778	202	7	5	643	5	ING5	2	242662623	Splice_Site	SNP	A	TCGA-CR-7371-01A-11D-2012-08	40657485	242662623	536750	48	25935											
SMARCC1	6599	broad.mit.edu	37	chr3	47712147	47712147	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	catatgcattaatctgcttaCctccaggagtagaagggtct	11	12	9	9	0	2	1	0	0	2	1	3	2	3	2	2	2	3	3	2	2	5	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:47712147C>A	uc003crq.2	-	19	2017	c.1899_splice	c.e19+1	p.E633_splice	SMARCC1_uc011bbc.1_Splice_Site|SMARCC1_uc011bbd.1_Splice_Site_p.E524_splice	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated						chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		AATCTGCTTACCTCCAGGAGT	0.289													5	20					0.00198382	0.00369665	1	0	A	47712147	A	A	47712147	5	1	142	1	0	0	0	0	0	0	1	0	14839	521	18	4	1457	4	SMARCC1	3	47712147	Splice_Site	SNP	C	TCGA-CR-7371-01A-11D-2012-08		47712147	150310283	49	25936											
CNTN3	5067	broad.mit.edu	37	chr3	74350693	74350693	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcttcccatcgatgacctCaggcactacaaaggaatatt	12	10	7	12	2	2	1	1	1	1	0	4	3	3	2	2	2	1	1	2	2	4	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:74350693C>A	uc003dpm.1	-	15	2031	c.1951G>T	c.(1951-1953)GAG>TAG	p.E651*		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	651	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TCGATGACCTCAGGCACTACA	0.448													25	48					1.66031e-10	3.49971e-10	1	0	A	74350693	A	A	74350693	4	1	142	1	0	0	0	0	0	1	0	0	3657	835	29	2	1167	2	CNTN3	3	74350693	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	26638546	74350693	123671737	50	25937											
CNTN3	5067	broad.mit.edu	37	chr3	74411068	74411068	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctcctgcacgctcacatccCccttcttccaggaagagagt	8	9	8	16	1	2	1	1	0	1	1	5	3	5	2	4	1	1	3	4	1	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:74411068C>T	uc003dpm.1	-	10	1417	c.1337G>A	c.(1336-1338)GGG>GAG	p.G446E		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	446	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GCTCACATCCCCCTTCTTCCA	0.473													12	35					0	0	0	0	T	74411068	T	T	74411068	3	4	142	1	0	0	0	0	1	0	0	0	3657	623	22	4	1801	4	CNTN3	3	74411068	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	60375	74411068	123611362	51	25938											
POU1F1	5449	broad.mit.edu	37	chr3	87325510	87325510	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcatggttggagactggtaGacactcggcagcactgtgat	9	9	15	8	1	0	3	0	1	0	2	1	4	0	3	0	5	1	5	0	5	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:87325510G>A	uc003dqq.1	-	1	228	c.103C>T	c.(103-105)CTA>TTA	p.L35L	POU1F1_uc010hoj.1_Silent_p.L35L	NM_000306	NP_000297	P28069	PIT1_HUMAN	pituitary specific transcription factor 1	35					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|skin(1)	2	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		GAGACTGGTAGACACTCGGCA	0.453													14	64					0	0	0	0	A	87325510	A	A	87325510	2	1	142	1	0	0	0	0	0	0	0	1	12324	933	33	2		2	POU1F1	3	87325510	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	12914442	87325510	110696920	52	25939											
LNP1	348801	broad.mit.edu	37	chr3	100170695	100170695	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggatgggtcattcaaggagCcactggaatcaaaaggaaga	16	6	13	6	0	3	1	3	0	0	1	3	5	3	5	1	5	1	0	1	5	5	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:100170695C>A	uc003dtx.3	+	3	1569	c.289C>A	c.(289-291)CCA>ACA	p.P97T	LNP1_uc003dty.3_RNA|LNP1_uc011bhb.1_RNA	NM_001085451	NP_001078920	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	97											0						ATTCAAGGAGCCACTGGAATC	0.453													15	59					3.45872e-05	6.75852e-05	1	0	A	100170695	A	A	100170695	3	1	142	1	0	0	0	0	1	0	0	0	8905	739	26	4	295	4	LNP1	3	100170695	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	12845185	100170695	97851735	53	25940											
ADCY5	111	broad.mit.edu	37	chr3	123019032	123019032	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacctggcacctccacgatGagcacgtagatgagctcgat	11	7	10	13	3	0	3	0	2	0	1	2	5	1	3	3	1	2	4	3	1	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:123019032G>A	uc003egh.1	-	15	2835	c.2835C>T	c.(2833-2835)CTC>CTT	p.L945L	ADCY5_uc003egg.1_Silent_p.L578L|ADCY5_uc003egi.1_Silent_p.L504L	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	945	Helical; (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		CCTCCACGATGAGCACGTAGA	0.632													5	58					0	0	0	0	A	123019032	A	A	123019032	2	1	142	1	0	0	0	0	0	0	0	1	297	1277	45	2		2	ADCY5	3	123019032	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	22848337	123019032	75003398	54	25941											
PIK3R4	30849	broad.mit.edu	37	chr3	130463595	130463595	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaacccaattccaactggtGaccatcacattctcagtctt	12	11	5	13	0	3	2	2	1	2	1	5	2	4	2	3	1	2	0	3	1	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:130463595G>A	uc003enj.2	-	2	1049	c.468C>T	c.(466-468)GTC>GTT	p.V156V		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	156	Protein kinase.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TCCAACTGGTGACCATCACAT	0.443													14	84					0	0	0	0	A	130463595	A	A	130463595	2	1	142	1	0	0	0	0	0	0	0	1	11976	1277	45	2		2	PIK3R4	3	130463595	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	7444563	130463595	67558835	55	25942											
NEK11	79858	broad.mit.edu	37	chr3	130828653	130828653	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcttcatttcagggccgaGatctggacgataaaattcag	11	11	10	9	2	5	1	3	0	2	1	5	4	5	2	1	2	0	1	1	2	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:130828653G>A	uc003eny.2	+	5	669	c.343G>A	c.(343-345)GAT>AAT	p.D115N	NEK11_uc003enx.2_Missense_Mutation_p.D115N|NEK11_uc003eoa.2_Missense_Mutation_p.D115N|NEK11_uc003enz.2_5'UTR|NEK11_uc010htn.2_RNA|NEK11_uc011blk.1_5'UTR|NEK11_uc011bll.1_Missense_Mutation_p.D115N|NEK11_uc003enw.1_Missense_Mutation_p.D115N|NEK11_uc011blm.1_Missense_Mutation_p.D115N|NEK11_uc010hto.1_5'UTR	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1	115	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						TCAGGGCCGAGATCTGGACGA	0.333													8	101					0	0	0	0	A	130828653	A	A	130828653	3	1	142	1	0	0	0	0	1	0	0	0	10377	942	33	2	353	2	NEK11	3	130828653	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	365058	130828653	67193777	56	25943											
ATP1B3	483	broad.mit.edu	37	chr3	141622516	141622516	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttcctggctgcactcttctCattcacgatgtgggttatgc	5	15	10	11	1	3	0	2	0	2	0	5	1	4	0	1	2	2	4	1	2	1	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:141622516C>G	uc003eug.1	+	2	338	c.164C>G	c.(163-165)TCA>TGA	p.S55*	ATP1B3_uc011bne.1_RNA|ATP1B3_uc003euh.1_Nonsense_Mutation_p.S41*	NM_001679	NP_001670	P54709	AT1B3_HUMAN	Na+/K+ -ATPase beta 3 subunit	55	Helical; Signal-anchor for type II membrane protein; (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity				0						GCACTCTTCTCATTCACGATG	0.408													16	81					0	0	0	0	G	141622516	G	G	141622516	4	3	142	1	0	0	0	0	0	1	0	0	1136	838	29	2	170	2	ATP1B3	3	141622516	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	10793863	141622516	56399914	57	25944											
CPB1	1360	broad.mit.edu	37	chr3	148562481	148562481	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagccgattttggagaaaGactcgctccacccatactgg	11	8	10	12	2	0	3	0	0	0	3	2	5	1	3	3	2	2	1	3	2	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:148562481G>T	uc003ewl.2	+	8	728	c.705G>T	c.(703-705)AAG>AAT	p.K235N		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	235					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TTTGGAGAAAGACTCGCTCCA	0.438													14	101					9.05144e-12	1.98912e-11	1	0	T	148562481	T	T	148562481	3	4	142	1	0	0	0	0	1	0	0	0	3811	933	33	2	735	2	CPB1	3	148562481	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	6939965	148562481	49459949	58	25945											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			9	56					0	0	0	0	A	178936091	A	A	178936091	3	1	142	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	30373610	178936091	19086339	59	25946											
ZNF639	51193	broad.mit.edu	37	chr3	179051458	179051458	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtactgattcaaatgtgtgtCgagtatgcaaggaaagtttc	12	13	11	5	1	1	1	1	1	0	0	3	3	1	2	0	1	2	4	0	1	5	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:179051458C>T	uc003fjq.1	+	6	1049	c.706C>T	c.(706-708)CGA>TGA	p.R236*	ZNF639_uc003fjr.1_Nonsense_Mutation_p.R236*	NM_016331	NP_057415	Q9UID6	ZN639_HUMAN	zinc finger protein 639	236	C2H2-type 2.				initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			AAATGTGTGTCGAGTATGCAA	0.353													18	71					0	0	0	0	T	179051458	T	T	179051458	4	4	142	1	0	0	0	0	0	1	0	0	18123	876	31	1	720	1	ZNF639	3	179051458	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	115367	179051458	18970972	60	25947											
TTC14	151613	broad.mit.edu	37	chr3	180324283	180324283	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctctagatatgcgacaaaagGaagtttgaacaaagcaatag	18	8	9	6	1	1	2	0	1	1	1	1	4	1	3	0	1	3	2	0	1	9	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:180324283G>T	uc003fkk.2	+	9	1196	c.1064G>T	c.(1063-1065)GGA>GTA	p.G355V	TTC14_uc003fkl.2_Missense_Mutation_p.G355V|TTC14_uc003fkm.2_Missense_Mutation_p.G355V	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	355	TPR 3.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GCGACAAAAGGAAGTTTGAAC	0.373													11	135					5.50884e-06	1.0942e-05	1	0	T	180324283	T	T	180324283	3	4	142	1	0	0	0	0	1	0	0	0	16749	1174	41	2	1098	2	TTC14	3	180324283	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1272825	180324283	17698147	61	25948											
C3orf59	151963	broad.mit.edu	37	chr3	192516720	192516720	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgatggctttgcaggcctGataggcctgcatgaggctgc	7	10	15	9	0	0	3	0	3	0	0	0	4	0	3	2	4	3	4	2	4	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:192516720G>C	uc011bsp.1	-	2	1252	c.931C>G	c.(931-933)CAG>GAG	p.Q311E		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	311											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGCAGGCCTGATAGGCCTGC	0.557													3	73					0	0	0	0	C	192516720	C	C	192516720	3	2	142	1	0	0	0	0	1	0	0	0	2247	1299	45	2	548	2	C3orf59	3	192516720	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	12192437	192516720	5505710	62	25949											
ATP13A3	79572	broad.mit.edu	37	chr3	194169313	194169313	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattcatctcctattcctttCacatccactgaaggatttgg	10	15	5	11	0	3	1	2	1	1	0	6	2	5	2	3	2	0	0	3	2	3	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:194169313C>T	uc003fty.3	-	11	1425	c.1023G>A	c.(1021-1023)GTG>GTA	p.V341V	ATP13A3_uc003ftz.1_Silent_p.V47V	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	341					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CTATTCCTTTCACATCCACTG	0.333													11	53					0	0	0	0	T	194169313	T	T	194169313	2	4	142	1	0	0	0	0	0	0	0	1	1127	813	29	2		2	ATP13A3	3	194169313	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1652593	194169313	3853117	63	25950											
MUC20	200958	broad.mit.edu	37	chr3	195451995	195451995	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaagctaagggcctgtcctCagagagcagcgcctcttccg	9	7	12	13	2	2	2	1	0	1	2	4	3	4	2	4	1	3	2	4	1	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr3:195451995C>G	uc010hzo.2	+	2	647	c.521C>G	c.(520-522)TCA>TGA	p.S174*	MUC20_uc010hzp.2_Nonsense_Mutation_p.S139*|MUC20_uc011bte.1_5'Flank	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	345	10.|12 X 20 AA approximate tandem repeats of S-S-E-S-S-A-S-S-D-S-P-H-P-V-I-T-P-S-R-A.|Ser-rich.		Missing.|Missing.|Missing.|Missing.		protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		GGCCTGTCCTCAGAGAGCAGC	0.587													19	133					0	0	0	0	G	195451995	G	G	195451995	4	3	142	1	0	0	0	0	0	1	0	0	10029	838	29	2	527	2	MUC20	3	195451995	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1282682	195451995	2570435	64	25951											
LDB2	9079	broad.mit.edu	37	chr4	16760821	16760821	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccaaacaaaatgaaagggtTaatgtggcgtcatcttcaaa	16	10	8	7	1	3	1	2	1	1	0	4	1	4	1	1	2	1	1	1	2	6	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:16760821T>A	uc003goz.2	-	2	511	c.195A>T	c.(193-195)TTA>TTT	p.L65F	LDB2_uc003gpa.2_Missense_Mutation_p.L65F|LDB2_uc003gpb.2_Missense_Mutation_p.L65F|LDB2_uc011bxh.1_Missense_Mutation_p.L65F|LDB2_uc010iee.2_Missense_Mutation_p.L65F	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	65							LIM domain binding|transcription cofactor activity				0						ATGAAAGGGTTAATGTGGCGT	0.388													11	47					0	0	0	0	A	16760821	A	A	16760821	3	1	142	1	0	0	0	0	1	0	0	0	8736	1751	61	5	1063	5	LDB2	4	16760821	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08		16760821	174393455	65	25952											
SOD3	6649	broad.mit.edu	37	chr4	24801160	24801160	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccatgctggcgctactgtGttcctgcctgctcctggcag	4	11	12	14	1	0	0	0	0	0	0	2	0	2	0	4	2	5	5	4	2	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:24801160G>T	uc003gqz.2	+	2	222	c.17G>T	c.(16-18)TGT>TTT	p.C6F	SOD3_uc003gqy.1_RNA	NM_003102	NP_003093	P08294	SODE_HUMAN	superoxide dismutase 3, extracellular precursor	6					removal of superoxide radicals	extracellular space|nucleus|soluble fraction	copper ion binding|heparin binding|protein binding|superoxide dismutase activity|zinc ion binding				0		Breast(46;0.0503)				GCGCTACTGTGTTCCTGCCTG	0.662													3	13					0.004672	0.00859505	1	0	T	24801160	T	T	24801160	3	4	142	1	0	0	0	0	1	0	0	0	14986	1377	48	4	19	4	SOD3	4	24801160	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	8040339	24801160	166353116	66	25953											
ATP8A1	10396	broad.mit.edu	37	chr4	42602537	42602537	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagcaccatttctcaaaacTggaaagagaaaaggtgacat	18	7	8	8	0	1	2	1	1	1	1	2	4	1	3	1	2	2	1	1	2	6	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:42602537T>A	uc003gwr.2	-	6	642	c.410_splice	c.e6-1	p.V137_splice	ATP8A1_uc003gws.2_Splice_Site_p.V137_splice|ATP8A1_uc011byz.1_Splice_Site_p.V137_splice	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),						ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	TTCTCAAAACTGGAAAGAGAA	0.333													5	27					0	0	0	0	A	42602537	A	A	42602537	5	1	142	1	0	0	0	0	0	0	1	0	1194	1594	55	5	3292	5	ATP8A1	4	42602537	Splice_Site	SNP	T	TCGA-CR-7371-01A-11D-2012-08	17801377	42602537	148551739	67	25954											
ATP10D	57205	broad.mit.edu	37	chr4	47559897	47559897	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaggtctcccaggtgtgtGagagcccccagtgctccagt	8	8	13	12	0	1	2	0	1	1	2	3	3	2	2	4	2	2	1	4	2	1	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:47559897G>C	uc003gxk.1	+	12	2205	c.2041G>C	c.(2041-2043)GAG>CAG	p.E681Q	ATP10D_uc003gxl.1_Intron	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	681	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CCAGGTGTGTGAGAGCCCCCA	0.552													6	44					0	0	0	0	C	47559897	C	C	47559897	3	2	142	1	0	0	0	0	1	0	0	0	1120	1291	45	2	2083	2	ATP10D	4	47559897	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	4957360	47559897	143594379	68	25955											
AASDH	132949	broad.mit.edu	37	chr4	57221514	57221514	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accaccaagggctaatactcGaagagaagtagtggctgaca	15	6	11	9	1	0	2	0	1	0	1	1	4	0	2	2	2	1	3	2	2	6	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:57221514G>A	uc003hbn.2	-	6	1090	c.937C>T	c.(937-939)CGA>TGA	p.R313*	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Nonsense_Mutation_p.R160*|AASDH_uc003hbo.2_Nonsense_Mutation_p.R213*|AASDH_uc011cab.1_5'UTR|AASDH_uc010ihc.2_Nonsense_Mutation_p.R313*|AASDH_uc003hbp.2_Nonsense_Mutation_p.R313*	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	313					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				GCTAATACTCGAAGAGAAGTA	0.368													10	59					0	0	0	0	A	57221514	A	A	57221514	4	1	142	1	0	0	0	0	0	1	0	0	22	1066	37	1	2399	1	AASDH	4	57221514	Nonsense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	9661617	57221514	133932762	69	25956											
PPM1K	152926	broad.mit.edu	37	chr4	89189447	89189447	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatttacgtgaggctgcccCaaactattccaagctacaaa	13	9	6	13	1	0	1	0	1	0	0	1	1	1	1	4	1	5	2	4	1	6	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:89189447C>A	uc003hrm.3	-	5	1137	c.747G>T	c.(745-747)TTG>TTT	p.L249F		NM_152542	NP_689755	Q8N3J5	PPM1K_HUMAN	protein phosphatase 1K (PP2C domain containing)	249	PP2C-like.				protein dephosphorylation	mitochondrial matrix|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000192)		GAGGCTGCCCCAAACTATTCC	0.373													12	37					6.42651e-13	1.42965e-12	1	0	A	89189447	A	A	89189447	3	1	142	1	0	0	0	0	1	0	0	0	12403	593	21	4	383	4	PPM1K	4	89189447	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	31967933	89189447	101964829	70	25957											
FAM13A	10144	broad.mit.edu	37	chr4	89668809	89668809	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcagggcggctgctttcCgctcgcttctcctggagctt	2	13	11	15	3	2	0	1	0	1	0	6	1	4	1	3	3	2	5	3	3	0	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:89668809C>A	uc003hse.1	-	18	2563	c.2355G>T	c.(2353-2355)GCG>GCT	p.A785A	FAM13A_uc003hsa.1_Silent_p.A256A|FAM13A_uc003hsb.1_Silent_p.A459A|FAM13A_uc003hsd.1_Silent_p.A459A|FAM13A_uc003hsc.1_Silent_p.A445A|FAM13A_uc011cdq.1_Silent_p.A431A|FAM13A_uc003hsf.1_Silent_p.A371A|FAM13A_uc003hsg.1_Silent_p.A256A	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	785					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						GGCTGCTTTCCGCTCGCTTCT	0.498													25	141					3.73988e-18	8.58392e-18	1	0	A	89668809	A	A	89668809	2	1	142	1	0	0	0	0	0	0	0	1	5480	639	23	3		3	FAM13A	4	89668809	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	479362	89668809	101485467	71	25958											
GRID2	2895	broad.mit.edu	37	chr4	94693335	94693335	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctcgtcaattgatttgaccCctctggacattgacactttg	8	14	7	12	1	2	3	1	3	1	0	3	4	2	4	3	1	0	0	3	1	1	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:94693335C>G	uc011cdt.1	+	16	2968	c.2710C>G	c.(2710-2712)CCT>GCT	p.P904A	GRID2_uc011cdu.1_Missense_Mutation_p.P809A	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	904	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGATTTGACCCCTCTGGACAT	0.458													5	80					0	0	0	0	G	94693335	G	G	94693335	3	3	142	1	0	0	0	0	1	0	0	0	6811	623	22	4	2772	4	GRID2	4	94693335	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	5024526	94693335	96460941	72	25959											
CENPE	1062	broad.mit.edu	37	chr4	104035710	104035710	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcttttgtagcactgattCtaacaaaaacaataaaaata	18	12	5	6	0	1	1	0	1	1	0	1	1	1	1	0	1	3	3	0	1	9	7			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:104035710C>T	uc003hxb.1	-	46	7533	c.7443_splice	c.e46-1	p.E2481_splice	CENPE_uc003hxc.1_Splice_Site_p.E2360_splice	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E						blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		AGCACTGATTCTAACAAAAAC	0.348													5	25					0	0	0	0	T	104035710	T	T	104035710	5	4	142	1	0	0	0	0	0	0	1	0	3245	927	32	2	679	2	CENPE	4	104035710	Splice_Site	SNP	C	TCGA-CR-7371-01A-11D-2012-08	9342375	104035710	87118566	73	25960											
COL25A1	84570	broad.mit.edu	37	chr4	109769944	109769944	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atccattcctgggattcctgGagatccctgctctccctatt	6	14	7	14	0	1	1	0	0	1	1	6	3	5	2	5	2	1	1	5	2	1	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:109769944G>C	uc003hze.1	-	26	1936	c.1405C>G	c.(1405-1407)CCA>GCA	p.P469A	COL25A1_uc003hzg.2_Missense_Mutation_p.P469A|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Missense_Mutation_p.P227A	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	469	Extracellular (Potential).|Collagen-like 6.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		GGGATTCCTGGAGATCCCTGC	0.348													9	36					0	0	0	0	C	109769944	C	C	109769944	3	2	142	1	0	0	0	0	1	0	0	0	3699	1174	41	2	691	2	COL25A1	4	109769944	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	5734234	109769944	81384332	74	25961											
CAMK2D	817	broad.mit.edu	37	chr4	114376956	114376956	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctcctgagaagttttctttCccatttggaatacagggtgg	8	14	10	9	0	1	1	0	1	1	1	3	3	3	2	3	3	1	1	3	3	3	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:114376956C>T	uc003ibi.2	-	18	2314	c.1455G>A	c.(1453-1455)GGG>GGA	p.G485G	CAMK2D_uc003ibj.2_Intron|CAMK2D_uc003ibk.2_Intron|CAMK2D_uc003ibo.3_Silent_p.G519G	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	485					interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		AGTTTTCTTTCCCATTTGGAA	0.423													6	36					0	0	0	0	T	114376956	T	T	114376956	2	4	142	1	0	0	0	0	0	0	0	1	2613	842	30	2		2	CAMK2D	4	114376956	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	4607012	114376956	76777320	75	25962											
PCDH10	57575	broad.mit.edu	37	chr4	134084409	134084409	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggactgctgactaatacGcgagcgccttacaaaccacc	12	7	9	13	3	0	1	0	1	0	0	0	4	0	2	3	1	5	1	3	1	4	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:134084409G>T	uc003iha.2	+	4	3901	c.3075G>T	c.(3073-3075)ACG>ACT	p.T1025T		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	1025	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TGACTAATACGCGAGCGCCTT	0.483													14	134					6.72482e-11	1.44704e-10	1	0	T	134084409	T	T	134084409	2	4	142	1	0	0	0	0	0	0	0	1	11561	1074	38	3		3	PCDH10	4	134084409	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	19707453	134084409	57069867	76	25963											
ELF2	1998	broad.mit.edu	37	chr4	139980635	139980635	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgactacctttggagaggtCgctgttgttggactagtgct	7	14	13	7	1	0	2	0	1	0	1	1	4	0	3	1	3	2	4	1	3	2	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:139980635C>T	uc003ihp.1	-	9	1454	c.1248G>A	c.(1246-1248)GCG>GCA	p.A416A	ELF2_uc003ihm.1_Silent_p.A368A|ELF2_uc003ihn.1_Silent_p.A356A|ELF2_uc003iho.1_Silent_p.A339A|ELF2_uc011chc.1_Silent_p.A231A	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	428					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					TTGGAGAGGTCGCTGTTGTTG	0.428													12	34					0	0	0	0	T	139980635	T	T	139980635	2	4	142	1	0	0	0	0	0	0	0	1	5078	871	31	1		1	ELF2	4	139980635	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	5896226	139980635	51173641	77	25964											
FBXW7	55294	broad.mit.edu	37	chr4	153247311	153247311	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgctgcaacatgacccatCaaaacatgtaaacactggcc	15	7	6	13	0	1	1	1	1	0	0	1	1	1	1	2	1	5	3	2	1	5	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:153247311C>T	uc003ims.2	-	10	1640	c.1491G>A	c.(1489-1491)TTG>TTA	p.L497L	FBXW7_uc011cii.1_Silent_p.L497L|FBXW7_uc003imt.2_Silent_p.L497L|FBXW7_uc011cih.1_Silent_p.L321L|FBXW7_uc003imq.2_Silent_p.L417L|FBXW7_uc003imr.2_Silent_p.L379L	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	497	WD 3.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CATGACCCATCAAAACATGTA	0.453			Mis|N|D|F		colorectal|endometrial|T-ALL								5	74					0	0	0	0	T	153247311	T	T	153247311	2	4	142	1	0	0	0	0	0	0	0	1	5801	825	29	2		2	FBXW7	4	153247311	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	13266676	153247311	37906965	78	25965											
MARCH1	55016	broad.mit.edu	37	chr4	164466767	164466767	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccattgtcattgccttgcttGatttcctccgctgtccggtc	3	16	8	14	2	1	1	1	1	0	0	5	1	4	1	5	1	2	2	5	1	0	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:164466767G>C	uc003iqs.1	-	7	1529	c.552C>G	c.(550-552)ATC>ATG	p.I184M	MARCH1_uc003iqr.1_Missense_Mutation_p.I167M	NM_017923	NP_060393	Q8TCQ1	MARH1_HUMAN	membrane-associated RING-CH protein I	184					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGCCTTGCTTGATTTCCTCCG	0.438													3	39					0	0	0	0	C	164466767	C	C	164466767	3	2	142	1	0	0	0	0	1	0	0	0	9351	1280	45	2	325	2	MARCH1	4	164466767	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	11219456	164466767	26687509	79	25966											
TLL1	7092	broad.mit.edu	37	chr4	166795090	166795090	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctttccccgaggatgctcGtgtggctggtggcctcgggg	2	10	17	12	4	0	0	0	0	0	0	3	2	1	1	3	6	1	3	3	6	0	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:166795090G>A	uc003irh.1	+	1	681	c.34G>A	c.(34-36)GTG>ATG	p.V12M	TLL1_uc011cjn.1_Missense_Mutation_p.V12M|TLL1_uc011cjo.1_Translation_Start_Site	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	12					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GAGGATGCTCGTGTGGCTGGT	0.592													8	120					0	0	0	0	A	166795090	A	A	166795090	3	1	142	1	0	0	0	0	1	0	0	0	16011	1145	40	1	36	1	TLL1	4	166795090	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	2328323	166795090	24359186	80	25967											
GPM6A	2823	broad.mit.edu	37	chr4	176573010	176573010	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacgaaggtccaagcagagAtttgctccctccactaatgt	11	10	9	11	1	0	2	0	1	0	1	3	4	3	2	3	1	2	2	3	1	3	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr4:176573010A>G	uc003iuf.2	-	4	1320	c.516T>C	c.(514-516)AAT>AAC	p.N172N	GPM6A_uc011ckj.1_Silent_p.N165N|GPM6A_uc003iug.2_Silent_p.N172N|GPM6A_uc003iuh.2_Silent_p.N161N	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	172	Extracellular (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		CCAAGCAGAGATTTGCTCCCT	0.463													10	74					0	0	0	0	G	176573010	G	G	176573010	2	3	142	1	0	0	0	0	0	0	0	1	6653	330	12	5		5	GPM6A	4	176573010	Silent	SNP	A	TCGA-CR-7371-01A-11D-2012-08	9777920	176573010	14581266	81	25968											
SDHA	6389	broad.mit.edu	37	chr5	228381	228381	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggggagtgccgtggtgtcAtcgcactgtgcatagaggac	8	9	16	8	2	1	1	1	0	0	1	2	3	1	3	1	4	2	2	1	4	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:228381A>T	uc003jao.3	+	6	818	c.703A>T	c.(703-705)ATC>TTC	p.I235F	SDHA_uc003jan.2_Missense_Mutation_p.I235F|SDHA_uc011clv.1_Missense_Mutation_p.I235F|SDHA_uc011clw.1_Missense_Mutation_p.I187F|SDHA_uc003jap.3_Missense_Mutation_p.I235F|SDHA_uc003jaq.3_Missense_Mutation_p.I10F|SDHA_uc003jar.3_5'Flank	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	235					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	CCGTGGTGTCATCGCACTGTG	0.428									Familial_Paragangliomas				3	38					0	0	0	0	T	228381	T	T	228381	3	4	142	1	0	0	0	0	1	0	0	0	14028	217	8	5	725	5	SDHA	5	228381	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08		228381	180686879	82	25969											
ADCY2	108	broad.mit.edu	37	chr5	7717278	7717278	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttcatatagaaccaagtCacaaaagaagagatttgaag	18	11	7	5	0	2	4	2	1	0	3	2	5	2	4	1	0	1	0	1	0	8	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:7717278C>A	uc003jdz.1	+	12	1698	c.1631C>A	c.(1630-1632)TCA>TAA	p.S544*	ADCY2_uc011cmo.1_Nonsense_Mutation_p.S364*	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	544	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AGAACCAAGTCACAAAAGAAG	0.239													5	50					8.12818e-05	0.000156711	1	0	A	7717278	A	A	7717278	4	1	142	1	0	0	0	0	0	1	0	0	294	838	29	2	1677	2	ADCY2	5	7717278	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	7488897	7717278	173197982	83	25970											
CTNND2	1501	broad.mit.edu	37	chr5	11236806	11236806	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atccaaggagcactgacctcGgctttaattttgttgtctcc	8	14	8	11	1	1	1	0	1	1	0	4	2	2	2	3	2	1	3	3	2	2	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:11236806G>T	uc003jfa.1	-	10	1903	c.1758C>A	c.(1756-1758)GCC>GCA	p.A586A	CTNND2_uc010itt.2_Silent_p.A495A|CTNND2_uc011cmy.1_Silent_p.A249A|CTNND2_uc011cmz.1_Silent_p.A153A|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.A153A	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	586	ARM 3.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CACTGACCTCGGCTTTAATTT	0.443													27	115					2.79863e-10	5.88201e-10	1	0	T	11236806	T	T	11236806	2	4	142	1	0	0	0	0	0	0	0	1	4037	1103	39	3		3	CTNND2	5	11236806	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	3519528	11236806	169678454	84	25971											
PARP8	79668	broad.mit.edu	37	chr5	50092850	50092850	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcattccagtacgagaccGtggcttcctggtgcaggtat	8	11	12	10	2	0	1	0	0	0	1	2	2	2	1	3	3	3	5	3	3	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:50092850G>A	uc003jon.3	+	14	1645	c.1463G>A	c.(1462-1464)CGT>CAT	p.R488H	PARP8_uc011cpz.1_Missense_Mutation_p.R380H|PARP8_uc003joo.2_Missense_Mutation_p.R488H|PARP8_uc003jop.2_Missense_Mutation_p.R488H	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	488						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GTACGAGACCGTGGCTTCCTG	0.294													8	20					0	0	0	0	A	50092850	A	A	50092850	3	1	142	1	0	0	0	0	1	0	0	0	11519	1145	40	1	1513	1	PARP8	5	50092850	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	38856044	50092850	130822410	85	25972											
HTR1A	3350	broad.mit.edu	37	chr5	63256365	63256365	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgtaaatgacggggttaagCagagagttggagtagcccag	12	7	16	6	2	0	2	0	1	0	1	0	4	0	3	1	3	2	5	1	3	4	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:63256365C>A	uc011cqt.1	-	1	1182	c.1182G>T	c.(1180-1182)CTG>CTT	p.L394L		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	394	Helical; Name=7; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CGGGGTTAAGCAGAGAGTTGG	0.498													47	159					4.01344e-20	9.30037e-20	1	0	A	63256365	A	A	63256365	2	1	142	1	0	0	0	0	0	0	0	1	7475	697	25	4		4	HTR1A	5	63256365	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	13163515	63256365	117658895	86	25973											
HTR1A	3350	broad.mit.edu	37	chr5	63256923	63256923	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagagaaccagcatgagcagCagcgggatgtagaaagctcc	14	5	13	9	1	0	3	0	1	0	2	1	5	1	4	2	1	6	5	2	1	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:63256923C>A	uc011cqt.1	-	1	624	c.624G>T	c.(622-624)CTG>CTT	p.L208L		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	208	Helical; Name=5; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GCATGAGCAGCAGCGGGATGT	0.592													37	122					2.66277e-13	5.96031e-13	1	0	A	63256923	A	A	63256923	2	1	142	1	0	0	0	0	0	0	0	1	7475	697	25	4		4	HTR1A	5	63256923	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	558	63256923	117658337	87	25974											
MSH3	4437	broad.mit.edu	37	chr5	79966002	79966002	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actgcttccaaatcagctaaCaaacggtccaaaagcatcta	16	8	5	12	1	2	0	1	0	1	0	4	0	4	0	2	1	5	3	2	1	6	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:79966002C>G	uc003kgz.2	+	4	919	c.666C>G	c.(664-666)AAC>AAG	p.N222K		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	222	Interaction with EXO1.				maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		AATCAGCTAACAAACGGTCCA	0.378								MMR					8	22					0	0	0	0	G	79966002	G	G	79966002	3	3	142	1	0	0	0	0	1	0	0	0	9924	477	17	4	680	4	MSH3	5	79966002	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	16709079	79966002	100949258	88	25975											
C5orf36	285600	broad.mit.edu	37	chr5	93856022	93856022	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccacacgaacagcattttCtctgaactgcagctcacaaa	15	8	5	13	1	2	1	1	1	1	0	3	2	2	1	1	0	6	3	1	0	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:93856022C>G	uc011cuk.1	-	5	1158	c.901G>C	c.(901-903)GAA>CAA	p.E301Q	C5orf36_uc003kkp.2_Missense_Mutation_p.E301Q	NM_001145678	NP_001139150	Q8IV33	K0825_HUMAN	hypothetical protein LOC285600 isoform 1	301											0		all_cancers(142;2.12e-08)|all_epithelial(76;5.95e-11)|all_lung(232;0.000996)|Lung NSC(167;0.0108)|Ovarian(174;0.0218)|Colorectal(57;0.0329)|Breast(839;0.214)|Lung SC(612;0.236)		all cancers(79;3.96e-19)		ACAGCATTTTCTCTGAACTGC	0.363													9	18					0	0	0	0	G	93856022	G	G	93856022	3	3	142	1	0	0	0	0	1	0	0	0	2305	922	32	2	2999	2	C5orf36	5	93856022	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	13890020	93856022	87059238	89	25976											
GPR150	285601	broad.mit.edu	37	chr5	94957182	94957182	+	Frame_Shift_Del	DEL	T	-	-																															cgccaacgctggccccacccTcattatcaccatgctcggcg																										TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:94957182delT	uc003kle.1	+	1	1203	c.1203delT	c.(1201-1203)CCTfs	p.P401fs		NM_199243	NP_954713	Q8NGU9	GP150_HUMAN	G protein-coupled receptor 150	401	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(142;0.000462)|all_epithelial(76;2.44e-06)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)		all cancers(79;1.82e-16)		GGCCCCACCCTCATTATCACC	0.726													---	---	---								-	94957182	-	-	94957182	7	5	142	1	0	1	0	1	0	0	0	0	6694	1538	54	0	1205	0	GPR150	5	94957182	Frame_Shift_Del	DEL	T	TCGA-CR-7371-01A-11D-2012-08	1101160	94957182	85958078	90	25977											
SRFBP1	153443	broad.mit.edu	37	chr5	121355833	121355833	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgttgctgaagttgagTcatcaaagaatgcttcagag	15	11	10	5	0	3	4	3	2	0	2	3	4	3	4	0	0	2	4	0	0	5	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:121355833T>A	uc003kst.1	+	6	475	c.403T>A	c.(403-405)TCA>ACA	p.S135T		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	135	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		TGAAGTTGAGTCATCAAAGAA	0.368													12	31					0	0	0	0	A	121355833	A	A	121355833	3	1	142	1	0	0	0	0	1	0	0	0	15210	1667	58	5	425	5	SRFBP1	5	121355833	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	26398651	121355833	59559427	91	25978											
PCDHB16	57717	broad.mit.edu	37	chr5	140562680	140562680	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctcatttccgggttctaatCcatgaattcagagatggcag	10	13	9	9	1	3	2	2	1	2	1	6	3	5	2	2	2	0	2	2	2	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:140562680C>T	uc003liv.2	+	1	1701	c.546C>T	c.(544-546)ATC>ATT	p.I182I	PCDHB16_uc010jfw.1_Intron	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	182	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGTTCTAATCCATGAATTCA	0.458													12	33					0	0	0	0	T	140562680	T	T	140562680	2	4	142	1	0	0	0	0	0	0	0	1	11595	845	30	2		2	PCDHB16	5	140562680	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	19206847	140562680	40352580	92	25979											
PCDHB16	57717	broad.mit.edu	37	chr5	140563947	140563947	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatgcctggctgtcgtacCagctgctcaaggccacggag	9	7	13	12	2	1	1	1	0	0	1	2	2	1	2	3	3	4	4	3	3	3	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:140563947C>A	uc003liv.2	+	1	2968	c.1813C>A	c.(1813-1815)CAG>AAG	p.Q605K	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	605	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGTCGTACCAGCTGCTCAA	0.706													35	101					2.87052e-16	6.52637e-16	1	0	A	140563947	A	A	140563947	3	1	142	1	0	0	0	0	1	0	0	0	11595	595	21	4	1815	4	PCDHB16	5	140563947	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1267	140563947	40351313	93	25980											
ARAP3	64411	broad.mit.edu	37	chr5	141033762	141033762	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggggggcctggagggggctCaggtggcctctcctcctggc	3	7	19	12	0	2	0	1	0	1	0	4	1	3	1	4	9	0	1	4	9	0	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:141033762C>G	uc003llm.2	-	33	4468	c.4390G>C	c.(4390-4392)GAG>CAG	p.E1464Q	ARAP3_uc003lll.2_Missense_Mutation_p.E415Q|ARAP3_uc011dbe.1_Missense_Mutation_p.E1113Q|ARAP3_uc003lln.2_Missense_Mutation_p.E1295Q	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1464	Pro-rich.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						GGAGGGGGCTCAGGTGGCCTC	0.612													15	48					0	0	0	0	G	141033762	G	G	141033762	3	3	142	1	0	0	0	0	1	0	0	0	840	835	29	2	248	2	ARAP3	5	141033762	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	469815	141033762	39881498	94	25981											
PCDH1	5097	broad.mit.edu	37	chr5	141233941	141233941	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcatgtgtcagagtggccaAactcactgcactcccgggta	10	8	11	12	1	2	1	2	0	0	1	3	1	3	1	2	2	3	3	2	2	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:141233941A>T	uc003llp.2	-	5	3497	c.3380T>A	c.(3379-3381)TTT>TAT	p.F1127Y		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		AGAGTGGCCAAACTCACTGCA	0.587													8	21					0	0	0	0	T	141233941	T	T	141233941	3	4	142	1	0	0	0	0	1	0	0	0	11560	14	1	5	337	5	PCDH1	5	141233941	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	200179	141233941	39681319	95	25982											
DOCK2	1794	broad.mit.edu	37	chr5	169484632	169484632	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgactgcatacaagctgccgGggatcctgcgctggtttgag	7	10	14	10	2	0	2	0	2	0	0	1	3	1	3	2	3	5	4	2	3	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:169484632G>C	uc003maf.2	+	44	4509	c.4429G>C	c.(4429-4431)GGG>CGG	p.G1477R	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.G969R|DOCK2_uc003mah.2_Missense_Mutation_p.G33R	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1477	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAAGCTGCCGGGGATCCTGCG	0.582													12	43					0	0	0	0	C	169484632	C	C	169484632	3	2	142	1	0	0	0	0	1	0	0	0	4709	1232	43	4	4603	4	DOCK2	5	169484632	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	28250691	169484632	11430628	96	25983											
FLT4	2324	broad.mit.edu	37	chr5	180057697	180057697	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtagggcctggcgtctgtGccctcgcagtctcgcaccac	5	8	12	16	3	2	0	0	0	2	0	4	0	2	0	3	2	1	3	3	2	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr5:180057697G>A	uc003mma.3	-	3	337	c.258C>T	c.(256-258)GGC>GGT	p.G86G	FLT4_uc003mlz.3_Silent_p.G86G|FLT4_uc003mmb.1_5'Flank|FLT4_uc011dgy.1_Silent_p.G86G|FLT4_uc011dgz.1_Silent_p.G86G|FLT4_uc011dha.1_Silent_p.G86G	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	86	Ig-like C2-type 1.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGCGTCTGTGCCCTCGCAGT	0.632									Congenital_Hereditary_Lymphedema				16	51					0	0	0	0	A	180057697	A	A	180057697	2	1	142	1	0	0	0	0	0	0	0	1	5976	1306	46	4		4	FLT4	5	180057697	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	10573065	180057697	857563	97	25984											
HIST1H2BG	8339	broad.mit.edu	37	chr6	26216847	26216847	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggaacccttcttcggagcagGagctgacttagctggttcag	8	10	13	10	1	2	1	1	1	1	0	3	4	2	4	1	4	4	4	1	4	2	4	rs149681157		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:26216847G>C	uc003ngz.2	-	1	26	c.25C>G	c.(25-27)CCT>GCT	p.P9A	HIST1H2AE_uc003nha.1_5'Flank	NM_003518	NP_003509	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	9					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				TTCGGAGCAGGAGCTGACTTA	0.483													11	67					0	0	0	0	C	26216847	C	C	26216847	3	2	142	1	0	0	0	0	1	0	0	0	7185	1174	41	2	359	2	HIST1H2BG	6	26216847	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08		26216847	144898220	98	25985											
TNXB	7148	broad.mit.edu	37	chr6	32036752	32036752	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggagttgcccgtctctatCtgtgtactggatttcgaagg	6	15	12	8	2	2	0	0	0	2	0	4	3	2	2	1	3	2	2	1	3	3	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:32036752C>G	uc003nzl.2	-	16	5951	c.5749G>C	c.(5749-5751)GAT>CAT	p.D1917H		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1999	Fibronectin type-III 12.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCGTCTCTATCTGTGTACTGG	0.552													17	61					0	0	0	0	G	32036752	G	G	32036752	3	3	142	1	0	0	0	0	1	0	0	0	16412	913	32	2	9080	2	TNXB	6	32036752	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	5819905	32036752	139078315	99	25986											
DNAH8	1769	broad.mit.edu	37	chr6	38834618	38834618	+	Frame_Shift_Del	DEL	T	-	-																															ggctcaaaaattttacgttcTttacaaactctgtgaagagc																										TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:38834618delT	uc003ooe.1	+	45	6608	c.6008delT	c.(6007-6009)CTTfs	p.L2003fs		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTTTACGTTCTTTACAAACTC	0.303													---	---	---								-	38834618	-	-	38834618	7	5	142	1	0	1	0	1	0	0	0	0	4629	1609	56	0	6178	0	DNAH8	6	38834618	Frame_Shift_Del	DEL	T	TCGA-CR-7371-01A-11D-2012-08	6797866	38834618	132280449	100	25987											
APOBEC2	10930	broad.mit.edu	37	chr6	41029282	41029282	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccttcgacccagccctgcGgtacaatgtcacctggtatg	8	9	10	14	2	1	0	1	0	0	0	2	1	1	0	4	2	4	2	4	2	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:41029282G>A	uc003opl.2	+	2	494	c.347G>A	c.(346-348)CGG>CAG	p.R116Q	UNC5CL_uc010jxe.1_Intron|APOBEC2_uc010jxf.2_RNA	NM_006789	NP_006780	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	116					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCAGCCCTGCGGTACAATGTC	0.562													13	155					0	0	0	0	A	41029282	A	A	41029282	3	1	142	1	0	0	0	0	1	0	0	0	788	1116	39	1	353	1	APOBEC2	6	41029282	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	2194664	41029282	130085785	101	25988											
BAI3	577	broad.mit.edu	37	chr6	70040462	70040462	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctgcagccgctgttgtcCtggtaaacatcaaaatcaac	12	9	8	12	1	2	0	2	0	0	0	3	1	3	0	3	1	4	4	3	1	5	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:70040462C>T	uc003pev.3	+	23	3548	c.3100C>T	c.(3100-3102)CTG>TTG	p.L1034L	BAI3_uc010kak.2_Silent_p.L1034L|BAI3_uc011dxx.1_Silent_p.L240L|BAI3_uc003pex.1_Silent_p.L164L	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1034	Helical; Name=5; (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CGCTGTTGTCCTGGTAAACAT	0.353													5	26					0	0	0	0	T	70040462	T	T	70040462	2	4	142	1	0	0	0	0	0	0	0	1	1302	680	24	4		4	BAI3	6	70040462	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	29011180	70040462	101074605	102	25989											
FUT9	10690	broad.mit.edu	37	chr6	96651056	96651056	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcaacatccaaaggaattCttcgcccatttttaattgtc	12	14	4	11	1	2	0	1	0	1	0	5	1	3	1	2	1	1	0	2	1	4	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:96651056C>G	uc003pop.3	+	3	366	c.25C>G	c.(25-27)CTT>GTT	p.L9V		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	9	Cytoplasmic (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		CAAAGGAATTCTTCGCCCATT	0.393													15	69					0	0	0	0	G	96651056	G	G	96651056	3	3	142	1	0	0	0	0	1	0	0	0	6145	913	32	2	27	2	FUT9	6	96651056	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	26610594	96651056	74464011	103	25990											
FUT9	10690	broad.mit.edu	37	chr6	96651727	96651727	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaatgataaaaatttgatTcctaccatatctacttgtaa	15	15	4	7	0	2	2	1	2	1	0	3	2	3	2	2	0	2	1	2	0	8	8			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:96651727T>C	uc003pop.3	+	3	1037	c.696T>C	c.(694-696)ATT>ATC	p.I232I		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	232	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		AAAATTTGATTCCTACCATAT	0.358													5	21					0	0	0	0	C	96651727	C	C	96651727	2	2	142	1	0	0	0	0	0	0	0	1	6145	1771	62	5		5	FUT9	6	96651727	Silent	SNP	T	TCGA-CR-7371-01A-11D-2012-08	671	96651727	74463340	104	25991											
TMEM200A	114801	broad.mit.edu	37	chr6	130762242	130762243	+	Missense_Mutation	DNP	CG	GT	GT																															agttttcgaatggacagctcCgtggaggaggatgaacttat																										TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:130762242_130762243CG>GT	uc003qca.2	+	3	1546_1547	c.675_676CG>GT	c.(673-678)TCCGTG>TCGTTG	p.V226L	TMEM200A_uc010kfh.2_Missense_Mutation_p.V226L|TMEM200A_uc010kfi.2_Missense_Mutation_p.V226L|TMEM200A_uc003qcb.2_Missense_Mutation_p.V226L	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	226	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TGGACAGCTCCGTGGAGGAGGA	0.49													6	44					0	0	0	0	GT	130762243	GT	GT	130762242	3	3	142	1	0	0	0	0	1	0	0	0	16189	639	23	3	677	3	TMEM200A	6	130762242	Missense_Mutation	DNP	CG	TCGA-CR-7371-01A-11D-2012-08	34110515	130762242	40352825	105	25992											
TAAR6	319100	broad.mit.edu	37	chr6	132891511	132891511	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcagctgtgctacgcgaaCgtgaatgggtcctgtgtgaa	8	10	15	8	3	0	2	0	2	0	0	1	3	1	2	1	1	5	3	1	1	4	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:132891511C>A	uc011eck.1	+	1	51	c.51C>A	c.(49-51)AAC>AAA	p.N17K		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	17	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		GCTACGCGAACGTGAATGGGT	0.493													18	76					2.35188e-11	5.10634e-11	1	0	A	132891511	A	A	132891511	3	1	142	1	0	0	0	0	1	0	0	0	15558	535	19	3	53	3	TAAR6	6	132891511	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	2129269	132891511	38223556	106	25993											
TAAR1	134864	broad.mit.edu	37	chr6	132966284	132966284	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccaaaccaaatcaatacatCattcaaagtaggtggaataa	19	8	6	8	0	3	0	3	0	0	0	3	1	3	1	2	2	2	1	2	2	8	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:132966284C>G	uc003qdm.1	-	1	859	c.859G>C	c.(859-861)GAT>CAT	p.D287H		NM_138327	NP_612200	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	287	Extracellular (Potential).					plasma membrane					0	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	ATCAATACATCATTCAAAGTA	0.373													10	45					0	0	0	0	G	132966284	G	G	132966284	3	3	142	1	0	0	0	0	1	0	0	0	15555	826	29	2	164	2	TAAR1	6	132966284	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	74773	132966284	38148783	107	25994											
EYA4	2070	broad.mit.edu	37	chr6	133802716	133802716	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggaaaaataatccctccccGcctcctgatagtgacctgga	11	8	8	14	2	0	2	0	2	0	0	3	4	3	4	6	2	0	0	6	2	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:133802716G>T	uc003qec.3	+	12	1544	c.1086G>T	c.(1084-1086)CCG>CCT	p.P362P	EYA4_uc011ecq.1_Silent_p.P308P|EYA4_uc011ecr.1_Silent_p.P314P|EYA4_uc003qed.3_Silent_p.P362P|EYA4_uc003qee.3_Silent_p.P339P|EYA4_uc011ecs.1_Silent_p.P368P|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	362					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		ATCCCTCCCCGCCTCCTGATA	0.448													23	82					7.41877e-09	1.54576e-08	1	0	T	133802716	T	T	133802716	2	4	142	1	0	0	0	0	0	0	0	1	5356	1074	38	3		3	EYA4	6	133802716	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	836432	133802716	37312351	108	25995											
SYNE1	23345	broad.mit.edu	37	chr6	152554980	152554980	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagtccactggctatcaatgCgcgacagctcagagcgcagc	10	6	11	14	3	2	1	2	0	0	1	3	2	3	1	1	1	4	3	1	1	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:152554980C>T	uc010kiw.2	-	112	21250	c.20648G>A	c.(20647-20649)CGC>CAC	p.R6883H	SYNE1_uc010kiv.2_Missense_Mutation_p.R1407H|SYNE1_uc003qos.3_Missense_Mutation_p.R1407H|SYNE1_uc003qot.3_Missense_Mutation_p.R6812H|SYNE1_uc003qou.3_Missense_Mutation_p.R6883H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6883	Spectrin 21.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCTATCAATGCGCGACAGCTC	0.512										HNSCC(10;0.0054)			10	39					0	0	0	0	T	152554980	T	T	152554980	3	4	142	1	0	0	0	0	1	0	0	0	15511	768	27	1	5958	1	SYNE1	6	152554980	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	18752264	152554980	18560087	109	25996											
RSPH3	83861	broad.mit.edu	37	chr6	159420840	159420840	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagcaacccagggttctgtCtgggggcgggaactccgggc	6	6	16	13	2	2	0	0	0	2	0	3	1	3	1	3	5	3	2	3	5	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr6:159420840C>G	uc003qrx.2	-	1	359	c.169G>C	c.(169-171)GAC>CAC	p.D57H	RSPH3_uc010kju.2_Missense_Mutation_p.D57H|RSPH3_uc003qry.1_Missense_Mutation_p.D57H	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	57										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		AGGGTTCTGTCTGGGGGCGGG	0.682													13	66					0	0	0	0	G	159420840	G	G	159420840	3	3	142	1	0	0	0	0	1	0	0	0	13770	913	32	2	1545	2	RSPH3	6	159420840	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	6865860	159420840	11694227	110	25997											
COL28A1	340267	broad.mit.edu	37	chr7	7412695	7412695	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtagcaattagattcatttCtttgtggaatatttcaaagt	13	17	7	4	0	3	1	2	0	1	1	3	2	3	2	0	1	1	2	0	1	6	7			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:7412695C>G	uc003src.1	-	32	2959	c.2842G>C	c.(2842-2844)GAA>CAA	p.E948Q	COL28A1_uc011jxe.1_Missense_Mutation_p.E631Q	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	948	VWFA 2.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		AGATTCATTTCTTTGTGGAAT	0.428													8	39					0	0	0	0	G	7412695	G	G	7412695	3	3	142	1	0	0	0	0	1	0	0	0	3701	922	32	2	551	2	COL28A1	7	7412695	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08		7412695	151725968	111	25998											
TARP	445347	broad.mit.edu	37	chr7	38305125	38305125	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctgggatcccagaatcgtGttgctcttcttttcttgcca	5	16	8	12	1	3	1	0	0	3	1	6	2	5	2	3	1	2	2	3	1	1	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:38305125G>T	uc003tge.1	-	5	959	c.582C>A	c.(580-582)AAC>AAA	p.N194K	uc003tfz.1_Intron|TARP_uc003tgb.2_5'UTR|TARP_uc003tgc.1_5'UTR|TARP_uc003tgd.1_5'UTR|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						CCAGAATCGTGTTGCTCTTCT	0.418													20	183					6.12954e-19	1.41586e-18	1	0	T	38305125	T	T	38305125	3	4	142	1	0	0	0	0	1	0	0	0	15624	1377	48	4	377	4	TARP	7	38305125	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	30892430	38305125	120833538	112	25999											
PKD1L1	168507	broad.mit.edu	37	chr7	47913505	47913505	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgttactcacaggtcctcGcccagacagtcatttccatg	8	12	8	13	1	2	1	2	0	0	1	5	1	4	1	3	1	1	1	3	1	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:47913505G>A	uc003tny.1	-	24	3888	c.3888C>T	c.(3886-3888)GGC>GGT	p.G1296G		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1296	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						ACAGGTCCTCGCCCAGACAGT	0.502													6	42					0	0	0	0	A	47913505	A	A	47913505	2	1	142	1	0	0	0	0	0	0	0	1	12019	1074	38	1		1	PKD1L1	7	47913505	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	9608380	47913505	111225158	113	26000											
EGFR	1956	broad.mit.edu	37	chr7	55221793	55221793	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accacgtaccagatggatgtGaaccccgagggcaaatacag	14	5	11	11	2	0	2	0	1	0	1	0	4	0	3	4	2	3	2	4	2	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:55221793G>A	uc003tqk.2	+	7	1083	c.837G>A	c.(835-837)GTG>GTA	p.V279V	EGFR_uc003tqh.2_Silent_p.V279V|EGFR_uc003tqi.2_Silent_p.V279V|EGFR_uc003tqj.2_Silent_p.V279V|EGFR_uc010kzg.1_Silent_p.V234V|EGFR_uc011kco.1_Silent_p.V226V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	279	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGATGGATGTGAACCCCGAGG	0.587		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			7	67					0	0	0	0	A	55221793	A	A	55221793	2	1	142	1	0	0	0	0	0	0	0	1	4989	1277	45	2		2	EGFR	7	55221793	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	7308288	55221793	103916870	114	26001											
AKAP9	10142	broad.mit.edu	37	chr7	91730347	91730347	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacttcaaactctgagccctGattctgaacatgtcacttta	11	14	5	11	0	4	3	2	3	2	0	4	3	4	3	1	0	4	0	1	0	4	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:91730347G>C	uc003ulg.2	+	45	11299	c.11074G>C	c.(11074-11076)GAT>CAT	p.D3692H	AKAP9_uc003ulf.2_Missense_Mutation_p.D3684H|AKAP9_uc003uli.2_Missense_Mutation_p.D3315H|AKAP9_uc003ulj.2_Missense_Mutation_p.D1462H|AKAP9_uc003ull.2_Missense_Mutation_p.D588H	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3696					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCTGAGCCCTGATTCTGAACA	0.383			T	BRAF	papillary thyroid								7	29					0	0	0	0	C	91730347	C	C	91730347	3	2	142	1	0	0	0	0	1	0	0	0	459	1290	45	2	11252	2	AKAP9	7	91730347	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	36508554	91730347	67408316	115	26002											
ZKSCAN5	23660	broad.mit.edu	37	chr7	99124010	99124010	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgcatctgatcgaacacctAaaacgccacttcagggagaa	14	7	8	12	3	2	2	1	1	1	1	4	4	2	2	2	1	2	1	2	1	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:99124010A>G	uc003uqv.2	+	6	1471	c.1347A>G	c.(1345-1347)CTA>CTG	p.L449L	ZKSCAN5_uc010lfx.2_Silent_p.L449L|ZKSCAN5_uc003uqw.2_Silent_p.L449L|ZKSCAN5_uc003uqx.2_Silent_p.L376L|ZKSCAN5_uc003uqy.2_Silent_p.L185L	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	449	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TCGAACACCTAAAACGCCACT	0.502													54	173					0	0	0	0	G	99124010	G	G	99124010	2	3	142	1	0	0	0	0	0	0	0	1	17757	349	13	5		5	ZKSCAN5	7	99124010	Silent	SNP	A	TCGA-CR-7371-01A-11D-2012-08	7393663	99124010	60014653	116	26003											
MUC17	140453	broad.mit.edu	37	chr7	100679091	100679091	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtatacctgtcagcaacaCgccggtggccaattctgagg	11	8	11	11	2	2	1	1	1	1	0	2	1	2	1	3	3	3	2	3	3	5	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:100679091C>A	uc003uxp.1	+	3	4447	c.4394C>A	c.(4393-4395)ACG>AAG	p.T1465K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1465	Extracellular (Potential).|Ser-rich.|22.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGCAACACGCCGGTGGCC	0.473													80	288					5.41795e-27	1.27595e-26	1	0	A	100679091	A	A	100679091	3	1	142	1	0	0	0	0	1	0	0	0	10027	536	19	3	4404	3	MUC17	7	100679091	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1555081	100679091	58459572	117	26004											
FBXL13	222235	broad.mit.edu	37	chr7	102665637	102665637	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcttttgagtattaacCtatttttccattttttcaat	9	21	3	8	0	2	1	1	1	1	0	3	1	3	1	2	0	2	2	2	0	4	10			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:102665637C>A	uc003vaq.2	-	6	795	c.368G>T	c.(367-369)AGG>ATG	p.R123M	FBXL13_uc010liq.1_Translation_Start_Site|FBXL13_uc010lir.1_Missense_Mutation_p.R123M|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.R123M|FBXL13_uc003vav.2_RNA	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	123											0						GAGTATTAACCTATTTTTCCA	0.318													8	19					0.000442599	0.000846559	1	0	A	102665637	A	A	102665637	3	1	142	1	0	0	0	0	1	0	0	0	5741	681	24	4	1899	4	FBXL13	7	102665637	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1986546	102665637	56473026	118	26005											
RELN	5649	broad.mit.edu	37	chr7	103237037	103237037	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagcactctctccgcctatCtggatgtagaactggacaaa	12	9	9	11	1	2	1	0	0	2	1	4	4	3	3	2	2	2	2	2	2	5	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:103237037C>A	uc003vca.2	-	25	3565	c.3405G>T	c.(3403-3405)CAG>CAT	p.Q1135H	RELN_uc010liz.2_Missense_Mutation_p.Q1135H	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1135					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTCCGCCTATCTGGATGTAGA	0.502													24	102					4.72057e-08	9.72357e-08	1	0	A	103237037	A	A	103237037	3	1	142	1	0	0	0	0	1	0	0	0	13285	912	32	2	7141	2	RELN	7	103237037	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	571400	103237037	55901626	119	26006											
HYAL4	23553	broad.mit.edu	37	chr7	123516942	123516942	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcataaggaagatgtggaaCgcgcccagttaccttcactt	11	10	10	10	2	1	1	1	0	0	1	1	3	1	3	2	2	3	2	2	2	4	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:123516942C>T	uc003vlc.2	+	5	1817	c.1179C>T	c.(1177-1179)AAC>AAT	p.N393N	HYAL4_uc011knz.1_3'UTR	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	393	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						AGATGTGGAACGCGCCCAGTT	0.507													10	60					0	0	0	0	T	123516942	T	T	123516942	2	4	142	1	0	0	0	0	0	0	0	1	7505	535	19	1		1	HYAL4	7	123516942	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	20279905	123516942	35621721	120	26007											
TRYX3	136541	broad.mit.edu	37	chr7	141952173	141952173	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatcccattgcagattgcCggggcagcagaaacttcctg	10	8	11	12	1	0	2	0	0	0	2	2	2	2	2	3	2	5	4	3	2	1	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:141952173C>T	uc003vxb.2	-	5	914	c.594G>A	c.(592-594)CCG>CCA	p.P198P	TRYX3_uc003vxc.3_Silent_p.P198P	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	198	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					TGCAGATTGCCGGGGCAGCAG	0.393													7	31					0	0	0	0	T	141952173	T	T	141952173	2	4	142	1	0	0	0	0	0	0	0	1	16671	639	23	1		1	TRYX3	7	141952173	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	18435231	141952173	17186490	121	26008											
OR2A14	135941	broad.mit.edu	37	chr7	143826781	143826781	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttggcctgtgctgacacctgGctcaaccaggtggtcatctt	6	12	11	12	0	3	1	2	1	1	0	3	1	3	1	3	4	2	2	3	4	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:143826781G>C	uc011kua.1	+	1	576	c.576G>C	c.(574-576)TGG>TGC	p.W192C		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					CTGACACCTGGCTCAACCAGG	0.562													48	240					0	0	0	0	C	143826781	C	C	143826781	3	2	142	1	0	0	0	0	1	0	0	0	11030	1212	42	4	578	4	OR2A14	7	143826781	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1874608	143826781	15311882	122	26009											
SSPO	23145	broad.mit.edu	37	chr7	149486333	149486333	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctggccctgctctgtgacCgccaggatgactgtggagat	6	9	13	13	1	1	3	0	2	1	1	1	5	1	4	4	3	1	1	4	3	0	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:149486333C>A	uc010lpk.2	+	30	4309	c.4309C>A	c.(4309-4311)CGC>AGC	p.R1437S		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1437	LDL-receptor class A 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCTCTGTGACCGCCAGGATGA	0.687													6	29					0.00198382	0.00369665	1	0	A	149486333	A	A	149486333	3	1	142	1	0	0	0	0	1	0	0	0	15255	652	23	3	4423	3	SSPO	7	149486333	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	5659552	149486333	9652330	123	26010											
RARRES2	5919	broad.mit.edu	37	chr7	150036164	150036164	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatgcaggccaggcatttccGtttcctctgtgggggagcgg	5	10	16	10	2	1	0	0	0	1	0	3	2	3	1	3	5	2	3	3	5	0	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr7:150036164G>C	uc003wha.2	-	4	403	c.286C>G	c.(286-288)CGG>GGG	p.R96G	RARRES2_uc010lpp.1_Missense_Mutation_p.R96G	NM_002889	NP_002880	Q99969	RARR2_HUMAN	chemerin preproprotein	96					embryonic digestive tract development|in utero embryonic development|positive regulation of macrophage chemotaxis|retinoid metabolic process	extracellular matrix	receptor binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.011)			AGGCATTTCCGTTTCCTCTGT	0.617													18	76					0	0	0	0	C	150036164	C	C	150036164	3	2	142	1	0	0	0	0	1	0	0	0	13121	1144	40	3	213	3	RARRES2	7	150036164	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	549831	150036164	9102499	124	26011											
ARHGEF10	9639	broad.mit.edu	37	chr8	1876769	1876769	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaccccgagaccccggccgtGagagcttctgatgtccccac	7	6	11	17	3	1	3	0	2	1	2	2	6	2	3	7	1	1	1	7	1	0	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:1876769G>C	uc003wpr.2	+	24	3052	c.2874G>C	c.(2872-2874)GTG>GTC	p.V958V	ARHGEF10_uc003wps.2_Silent_p.V920V|ARHGEF10_uc010lre.2_Silent_p.V609V	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	983					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CCCCGGCCGTGAGAGCTTCTG	0.612													6	60					0	0	0	0	C	1876769	C	C	1876769	2	2	142	1	0	0	0	0	0	0	0	1	894	1277	45	2		2	ARHGEF10	8	1876769	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08		1876769	144487253	125	26012											
CSMD1	64478	broad.mit.edu	37	chr8	3256980	3256980	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccattcacaatgtaaagaatCcttataatatcctggccatc	14	12	4	11	0	1	1	1	0	0	1	4	1	3	1	4	1	0	1	4	1	7	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:3256980C>G	uc011kwk.1	-	16	2731	c.2341G>C	c.(2341-2343)GAT>CAT	p.D781H	CSMD1_uc011kwj.1_Missense_Mutation_p.D173H	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	781	Extracellular (Potential).|CUB 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGTAAAGAATCCTTATAATAT	0.388													12	48					0	0	0	0	G	3256980	G	G	3256980	3	3	142	1	0	0	0	0	1	0	0	0	3961	855	30	2	8576	2	CSMD1	8	3256980	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1380211	3256980	143107042	126	26013											
PNOC	5368	broad.mit.edu	37	chr8	28196682	28196682	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcatgtggcggctgctctCtaccagccgagagcttcgga	7	8	14	12	3	1	1	0	0	1	1	3	4	1	2	2	3	5	4	2	3	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:28196682C>T	uc010lva.2	+	3	460	c.252C>T	c.(250-252)CTC>CTT	p.L84L	PNOC_uc003xgp.2_Silent_p.L84L|PNOC_uc011lau.1_Silent_p.L20L	NM_006228	NP_006219	Q13519	PNOC_HUMAN	prepronociceptin precursor	84					neuropeptide signaling pathway|sensory perception|synaptic transmission	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(1)	1		Ovarian(32;0.000953)		KIRC - Kidney renal clear cell carcinoma(542;0.104)|Kidney(114;0.125)|Colorectal(74;0.145)|BRCA - Breast invasive adenocarcinoma(99;0.245)		CGGCTGCTCTCTACCAGCCGA	0.652													12	63					0	0	0	0	T	28196682	T	T	28196682	2	4	142	1	0	0	0	0	0	0	0	1	12217	900	32	2		2	PNOC	8	28196682	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	24939702	28196682	118167340	127	26014											
TEX15	56154	broad.mit.edu	37	chr8	30695362	30695362	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcatgctatttaaatttTcctgttgtccactgaagtga	9	18	6	8	0	2	2	1	2	1	0	4	2	4	2	2	0	1	2	2	0	4	7			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:30695362T>A	uc003xil.2	-	3	7289	c.7289A>T	c.(7288-7290)GAA>GTA	p.E2430V		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2430										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATTTAAATTTTCCTGTTGTCC	0.358													39	157					0	0	0	0	A	30695362	A	A	30695362	3	1	142	1	0	0	0	0	1	0	0	0	15845	1783	62	5	1088	5	TEX15	8	30695362	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	2498680	30695362	115668660	128	26015											
MYST3	7994	broad.mit.edu	37	chr8	41791507	41791507	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaggaatctcttcctcctCttttaattcgattaactctt	9	18	4	10	1	3	1	0	1	3	0	7	3	5	2	2	1	1	0	2	1	3	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:41791507C>G	uc010lxb.2	-	18	4775	c.4231G>C	c.(4231-4233)GAG>CAG	p.E1411Q	MYST3_uc010lxc.2_Missense_Mutation_p.E1411Q|MYST3_uc003xon.3_Missense_Mutation_p.E1411Q	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1411	Poly-Glu.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TCTTCCTCCTCTTTTAATTCG	0.507													20	72					0	0	0	0	G	41791507	G	G	41791507	3	3	142	1	0	0	0	0	1	0	0	0	10157	922	32	2	1787	2	MYST3	8	41791507	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	11096145	41791507	104572515	129	26016											
MYST3	7994	broad.mit.edu	37	chr8	41798738	41798738	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgaagacgtctcttccaaGagcagtttagaatctttatc	11	13	8	9	1	2	4	0	1	2	3	5	4	3	4	1	0	1	3	1	0	5	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:41798738G>C	uc010lxb.2	-	16	3205	c.2661C>G	c.(2659-2661)CTC>CTG	p.L887L	MYST3_uc010lxc.2_Silent_p.L887L|MYST3_uc003xon.3_Silent_p.L887L	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	887					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TCTCTTCCAAGAGCAGTTTAG	0.483													14	58					0	0	0	0	C	41798738	C	C	41798738	2	2	142	1	0	0	0	0	0	0	0	1	10157	929	33	2		2	MYST3	8	41798738	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	7231	41798738	104565284	130	26017											
AP3M2	10947	broad.mit.edu	37	chr8	42024827	42024827	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcaccagccagatgcccaagGgggtcctgaacatgagcctt	10	7	11	13	0	1	3	1	2	0	1	2	3	2	3	5	2	4	0	5	2	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:42024827G>A	uc003xop.2	+	8	1240	c.949G>A	c.(949-951)GGG>AGG	p.G317R	AP3M2_uc003xoo.2_Missense_Mutation_p.G317R|AP3M2_uc010lxe.2_Intron	NM_001134296	NP_001127768	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	317	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus					0	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			GATGCCCAAGGGGGTCCTGAA	0.522													11	47					0	0	0	0	A	42024827	A	A	42024827	3	1	142	1	0	0	0	0	1	0	0	0	748	1232	43	4	971	4	AP3M2	8	42024827	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	226089	42024827	104339195	131	26018											
HOOK3	84376	broad.mit.edu	37	chr8	42868217	42868217	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atccgtactttagatcctaaAcagaatcaaggagcagcacc	15	8	7	11	1	1	2	1	0	0	2	3	3	3	3	3	1	4	3	3	1	6	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:42868217A>T	uc003xpr.2	+	20	2105	c.1863A>T	c.(1861-1863)AAA>AAT	p.K621N		NM_032410	NP_115786	Q86VS8	HOOK3_HUMAN	golgi-associated microtubule-binding protein	621	Potential.|Required for interaction with MSR1.|Required for association with Golgi.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			ovary(1)|breast(1)	2	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			TAGATCCTAAACAGAATCAAG	0.333			T	RET	papillary thyroid								6	22					0	0	0	0	T	42868217	T	T	42868217	3	4	142	1	0	0	0	0	1	0	0	0	7323	40	2	5	1941	5	HOOK3	8	42868217	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	843390	42868217	103495805	132	26019											
SNTG1	54212	broad.mit.edu	37	chr8	51617301	51617301	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcaacctttctagaagtaGaacggatacaggtgagagtc	14	8	11	8	1	1	3	0	1	1	3	2	5	1	4	1	2	4	2	1	2	6	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:51617301G>A	uc010lxy.1	+	17	1551	c.1180G>A	c.(1180-1182)GAA>AAA	p.E394K	SNTG1_uc003xqs.1_Missense_Mutation_p.E394K|SNTG1_uc010lxz.1_Missense_Mutation_p.E394K|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	394					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCTAGAAGTAGAACGGATACA	0.507													4	31					0	0	0	0	A	51617301	A	A	51617301	3	1	142	1	0	0	0	0	1	0	0	0	14938	943	33	2	1234	2	SNTG1	8	51617301	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	8749084	51617301	94746721	133	26020											
ST18	9705	broad.mit.edu	37	chr8	53073977	53073977	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtccttgcactgtttgtaTgagagggcgtttaccgaaaa	9	13	11	8	3	0	1	0	1	0	1	2	3	1	1	2	1	2	4	2	1	4	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:53073977T>A	uc003xqz.2	-	9	1708	c.1552A>T	c.(1552-1554)ATA>TTA	p.I518L	ST18_uc011ldq.1_Missense_Mutation_p.I165L|ST18_uc011ldr.1_Missense_Mutation_p.I483L|ST18_uc011lds.1_Missense_Mutation_p.I423L|ST18_uc003xra.2_Missense_Mutation_p.I518L|ST18_uc003xrb.2_Missense_Mutation_p.I518L	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	518						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ACTGTTTGTATGAGAGGGCGT	0.428													24	78					0	0	0	0	A	53073977	A	A	53073977	3	1	142	1	0	0	0	0	1	0	0	0	15278	1464	51	5	1643	5	ST18	8	53073977	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	1456676	53073977	93290045	134	26021											
RP1	6101	broad.mit.edu	37	chr8	55533682	55533682	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccccaattcggcggggtcagGgtggtggtcaaccctcgctc	5	8	14	14	3	2	0	2	0	0	0	5	0	2	0	3	6	1	1	3	6	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:55533682G>T	uc003xsd.1	+	2	304	c.156G>T	c.(154-156)AGG>AGT	p.R52S	RP1_uc011ldy.1_Missense_Mutation_p.R52S	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	52	Doublecortin 1.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GCGGGGTCAGGGTGGTGGTCA	0.557													15	65					7.93312e-07	1.59767e-06	1	0	T	55533682	T	T	55533682	3	4	142	1	0	0	0	0	1	0	0	0	13597	1223	43	4	158	4	RP1	8	55533682	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	2459705	55533682	90830340	135	26022											
VPS13B	157680	broad.mit.edu	37	chr8	100831006	100831006	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccattatcatacatttggaGaaaaggagtctgggattgag	13	11	11	6	0	2	2	1	1	1	1	2	5	2	4	1	3	1	0	1	3	4	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:100831006G>A	uc003yiv.2	+	47	8697	c.8586G>A	c.(8584-8586)GAG>GAA	p.E2862E	VPS13B_uc003yiw.2_Silent_p.E2837E	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2862					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TACATTTGGAGAAAAGGAGTC	0.373													15	111					0	0	0	0	A	100831006	A	A	100831006	2	1	142	1	0	0	0	0	0	0	0	1	17258	933	33	2		2	VPS13B	8	100831006	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	45297324	100831006	45533016	136	26023											
VPS13B	157680	broad.mit.edu	37	chr8	100831079	100831079	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaaccactgcaaaacataGaacctgaccttgtacatcac	18	7	4	12	0	1	2	1	1	0	1	1	2	1	2	3	0	5	2	3	0	7	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:100831079G>A	uc003yiv.2	+	47	8770	c.8659G>A	c.(8659-8661)GAA>AAA	p.E2887K	VPS13B_uc003yiw.2_Missense_Mutation_p.E2862K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2887					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GCAAAACATAGAACCTGACCT	0.378													13	67					0	0	0	0	A	100831079	A	A	100831079	3	1	142	1	0	0	0	0	1	0	0	0	17258	943	33	2	9035	2	VPS13B	8	100831079	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	73	100831079	45532943	137	26024											
SLC30A8	169026	broad.mit.edu	37	chr8	118183329	118183329	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcttattttagcagtcgacGgggtgctgtctgtgcacagc	7	12	13	9	2	1	0	0	0	1	0	2	1	1	0	0	2	5	4	0	2	2	3	rs139489847		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:118183329G>T	uc003yoh.2	+	7	1116	c.886G>T	c.(886-888)GGG>TGG	p.G296W	SLC30A8_uc010mcz.2_Missense_Mutation_p.G247W|SLC30A8_uc011lia.1_Missense_Mutation_p.G247W|SLC30A8_uc003yog.2_Missense_Mutation_p.G247W	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	296	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			AGCAGTCGACGGGGTGCTGTC	0.448													14	85					1.49906e-05	2.95319e-05	1	0	T	118183329	T	T	118183329	3	4	142	1	0	0	0	0	1	0	0	0	14625	1116	39	3	912	3	SLC30A8	8	118183329	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	17352250	118183329	28180693	138	26025											
COL14A1	7373	broad.mit.edu	37	chr8	121296005	121296005	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	attctgacccattggttgggGttattttagacagtaagtat	10	16	10	5	0	1	2	0	1	1	1	1	2	1	2	1	3	0	4	1	3	4	8			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:121296005G>T	uc003yox.2	+	32	4220	c.3955G>T	c.(3955-3957)GTT>TTT	p.V1319F	COL14A1_uc003yoz.2_Missense_Mutation_p.V284F	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1319	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ATTGGTTGGGGTTATTTTAGA	0.358													13	52					0.00136819	0.00257605	1	0	T	121296005	T	T	121296005	3	4	142	1	0	0	0	0	1	0	0	0	3686	1261	44	4	4077	4	COL14A1	8	121296005	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	3112676	121296005	25068017	139	26026											
FAM135B	51059	broad.mit.edu	37	chr8	139155262	139155262	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtttccttttacctaattcGggatatggagaggttgtaca	9	15	11	6	1	0	1	0	0	0	1	2	3	1	2	2	4	2	3	2	4	4	8			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:139155262G>T	uc003yuy.2	-	16	3802	c.3631C>A	c.(3631-3633)CGA>AGA	p.R1211R	FAM135B_uc003yux.2_Silent_p.R1112R|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.R773R|FAM135B_uc003yvb.2_3'UTR	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1211										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TACCTAATTCGGGATATGGAG	0.398										HNSCC(54;0.14)			4	32					1.23904e-05	2.44761e-05	1	0	T	139155262	T	T	139155262	2	4	142	1	0	0	0	0	0	0	0	1	5477	1124	39	3		3	FAM135B	8	139155262	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	17859257	139155262	7208760	140	26027											
FAM135B	51059	broad.mit.edu	37	chr8	139165260	139165260	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatatgattttgtgtggcCacattctcacctggctctgg	6	15	9	11	0	2	1	1	1	2	0	4	1	3	1	3	3	0	1	3	3	1	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:139165260C>T	uc003yuy.2	-	13	1629	c.1458G>A	c.(1456-1458)GTG>GTA	p.V486V	FAM135B_uc003yux.2_Silent_p.V387V|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.V48V|FAM135B_uc003yvb.2_Silent_p.V48V	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	486										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTTGTGTGGCCACATTCTCAC	0.393										HNSCC(54;0.14)			10	78					0	0	0	0	T	139165260	T	T	139165260	2	4	142	1	0	0	0	0	0	0	0	1	5477	581	21	4		4	FAM135B	8	139165260	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	9998	139165260	7198762	141	26028											
COL22A1	169044	broad.mit.edu	37	chr8	139614357	139614357	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgcctgtgctctccactcaCcctttctcctttgaatccag	5	14	6	16	0	3	1	1	1	2	0	6	1	4	1	5	0	2	1	5	0	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:139614357C>A	uc003yvd.2	-	60	4632	c.4185_splice	c.e60+1	p.R1395_splice	COL22A1_uc011ljo.1_Splice_Site_p.R675_splice	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCTCCACTCACCCTTTCTCCT	0.572										HNSCC(7;0.00092)			20	61					5.35267e-07	1.081e-06	1	0	A	139614357	A	A	139614357	5	1	142	1	0	0	0	0	0	0	1	0	3696	521	18	4	718	4	COL22A1	8	139614357	Splice_Site	SNP	C	TCGA-CR-7371-01A-11D-2012-08	449097	139614357	6749665	142	26029											
TSNARE1	203062	broad.mit.edu	37	chr8	143425409	143425409	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacctgctccacgggcgtGagagccagggcctggggctt	6	6	15	14	2	0	1	0	1	0	1	1	2	1	1	5	4	2	2	5	4	0	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:143425409G>T	uc003ywk.2	-	4	781	c.663C>A	c.(661-663)CTC>CTA	p.L221L	TSNARE1_uc011lju.1_Silent_p.L221L|TSNARE1_uc003ywj.2_Silent_p.L221L|TSNARE1_uc003ywl.3_Intron	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	221					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCACGGGCGTGAGAGCCAGGG	0.706													10	41					1.33987e-11	2.91785e-11	1	0	T	143425409	T	T	143425409	2	4	142	1	0	0	0	0	0	0	0	1	16697	1277	45	2		2	TSNARE1	8	143425409	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	3811052	143425409	2938613	143	26030											
JRK	8629	broad.mit.edu	37	chr8	143747266	143747266	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gctgctccagcgccttgttgGagtccgagctggcgaagaac	7	8	14	12	3	0	1	0	0	0	1	2	4	2	2	3	2	4	4	3	2	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:143747266G>C	uc003ywo.2	-	2	726	c.212C>G	c.(211-213)TCC>TGC	p.S71C	JRK_uc003ywp.2_Missense_Mutation_p.S71C|JRK_uc010mew.1_Missense_Mutation_p.S71C	NM_001077527	NP_001070995			jerky isoform b												0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				cgccttgttggagtccgagct	0													4	19					0	0	0	0	C	143747266	C	C	143747266	3	2	142	1	0	0	0	0	1	0	0	0	8003	1174	41	2	1594	2	JRK	8	143747266	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	321857	143747266	2616756	144	26031											
TSTA3	7264	broad.mit.edu	37	chr8	144696589	144696589	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacgttggtggggatgacagCggtgaaggtgcagccgtact	8	8	18	7	3	0	2	0	2	0	0	0	4	0	3	1	5	4	3	1	5	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr8:144696589C>T	uc003yza.2	-	6	535	c.499G>A	c.(499-501)GCT>ACT	p.A167T	TSTA3_uc003yzb.2_Missense_Mutation_p.A167T	NM_003313	NP_003304	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	167					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			pancreas(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	GGGATGACAGCGGTGAAGGTG	0.662													4	38					0	0	0	0	T	144696589	T	T	144696589	3	4	142	1	0	0	0	0	1	0	0	0	16741	768	27	1	490	1	TSTA3	8	144696589	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	949323	144696589	1667433	145	26032											
MPDZ	8777	broad.mit.edu	37	chr9	13168483	13168483	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccaatggcaatccggcCatctcgactaatggcacctc	9	8	8	16	2	1	0	0	0	1	0	5	1	3	0	5	3	0	2	5	3	3	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:13168483C>A	uc010mia.1	-	21	3193	c.3136G>T	c.(3136-3138)GGC>TGC	p.G1046C	MPDZ_uc003zkz.3_5'UTR|MPDZ_uc010mhy.2_Missense_Mutation_p.G1046C|MPDZ_uc010mhz.2_Missense_Mutation_p.G1046C|MPDZ_uc011lmn.1_Missense_Mutation_p.G1046C|MPDZ_uc003zlb.3_Missense_Mutation_p.G1046C	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1046	PDZ 6.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		GCAATCCGGCCATCTCGACTA	0.453													113	129					1.22118e-62	2.89479e-62	1	0	A	13168483	A	A	13168483	3	1	142	1	0	0	0	0	1	0	0	0	9775	594	21	4	3089	4	MPDZ	9	13168483	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08		13168483	128044948	146	26033											
LINGO2	158038	broad.mit.edu	37	chr9	27950478	27950478	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttttagcctgtttttactGaggtccaagattttggtttc	6	20	8	7	0	0	2	0	1	0	1	2	2	1	2	2	2	2	2	2	2	3	9			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:27950478G>A	uc003zqu.1	-	2	386	c.192C>T	c.(190-192)CTC>CTT	p.L64L	LINGO2_uc010mjf.1_Silent_p.L64L|LINGO2_uc003zqv.1_Silent_p.L64L	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	64	LRR 1.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TGTTTTTACTGAGGTCCAAGA	0.458													72	94					0	0	0	0	A	27950478	A	A	27950478	2	1	142	1	0	0	0	0	0	0	0	1	8857	1277	45	2		2	LINGO2	9	27950478	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	14781995	27950478	113262953	147	26034											
TAF1L	138474	broad.mit.edu	37	chr9	32631662	32631662	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaggtttcgaaggtggcaCatttgtttgataatagaggg	12	12	13	4	1	0	2	0	1	0	1	1	3	0	2	0	4	1	3	0	4	4	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:32631662C>T	uc003zrg.1	-	1	4006	c.3916G>A	c.(3916-3918)GTG>ATG	p.V1306M	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1306					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GAAGGTGGCACATTTGTTTGA	0.428													91	134					0	0	0	0	T	32631662	T	T	32631662	3	4	142	1	0	0	0	0	1	0	0	0	15589	478	17	4	1568	4	TAF1L	9	32631662	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	4681184	32631662	108581769	148	26035											
TAF1L	138474	broad.mit.edu	37	chr9	32633519	32633519	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tttgcctgtgagatcctgagGtgtgcgcataaaaaacaact	12	11	10	8	1	0	2	0	2	0	1	1	3	1	2	2	1	4	1	2	1	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:32633519G>A	uc003zrg.1	-	1	2149	c.2059C>T	c.(2059-2061)CCT>TCT	p.P687S	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	687					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGATCCTGAGGTGTGCGCATA	0.433													6	117					0	0	0	0	A	32633519	A	A	32633519	3	1	142	1	0	0	0	0	1	0	0	0	15589	1261	44	4	3425	4	TAF1L	9	32633519	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1857	32633519	108579912	149	26036											
KIAA1539	80256	broad.mit.edu	37	chr9	35107755	35107755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggggctggccctggggactCccccagggacccctgtcccc	4	5	14	18	0	0	0	0	0	0	0	2	2	2	2	7	6	0	1	7	6	0	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:35107755C>T	uc003zwl.2	-	3	842	c.517G>A	c.(517-519)GAG>AAG	p.E173K	KIAA1539_uc003zwm.2_Missense_Mutation_p.E173K|KIAA1539_uc003zwn.2_Intron|KIAA1539_uc003zwo.2_Missense_Mutation_p.E173K|KIAA1539_uc003zwp.1_Missense_Mutation_p.E173K|KIAA1539_uc010mkk.1_Intron	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	173						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CCTGGGGACTCCCCCAGGGAC	0.632													15	109					0	0	0	0	T	35107755	T	T	35107755	3	4	142	1	0	0	0	0	1	0	0	0	8281	864	30	2	1127	2	KIAA1539	9	35107755	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	2474236	35107755	106105676	150	26037											
SIT1	27240	broad.mit.edu	37	chr9	35650548	35650548	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcccctggtccactgggacaAgtgtgcagccagcgagatga	9	6	14	12	1	0	2	0	1	0	1	1	4	1	3	4	2	3	1	4	2	1	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:35650548A>T	uc003zxe.1	-	2	284	c.187T>A	c.(187-189)TTG>ATG	p.L63M	SIT1_uc003zxf.1_Intron	NM_014450	NP_055265	Q9Y3P8	SIT1_HUMAN	SHP2-interacting transmembrane adaptor protein	63	Cytoplasmic (Potential).				regulation of T cell activation|signal transduction	integral to plasma membrane	kinase binding|SH2 domain binding				0			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CACTGGGACAAGTGTGCAGCC	0.597													58	69					0	0	0	0	T	35650548	T	T	35650548	3	4	142	1	0	0	0	0	1	0	0	0	14409	69	3	5	419	5	SIT1	9	35650548	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	542793	35650548	105562883	151	26038											
PGM5	5239	broad.mit.edu	37	chr9	71002492	71002492	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aactgaagattcgcattgacGcaatgcacggaggtaagctt	13	9	11	8	3	0	3	0	2	0	1	1	4	0	4	0	2	3	5	0	2	4	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:71002492G>C	uc004agr.2	+	4	914	c.685G>C	c.(685-687)GCA>CCA	p.A229P		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	229					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						TCGCATTGACGCAATGCACGG	0.468													7	55					0	0	0	0	C	71002492	C	C	71002492	3	2	142	1	0	0	0	0	1	0	0	0	11856	1087	38	3	699	3	PGM5	9	71002492	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	35351944	71002492	70210939	152	26039											
C9orf135	138255	broad.mit.edu	37	chr9	72435949	72435949	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtgttggtgtattcctggTgagcgaagtcccctcgcaag	6	11	14	10	3	0	1	0	1	0	0	3	2	2	1	3	3	1	3	3	3	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:72435949T>A	uc004ahl.2	+	1	217	c.152_splice	c.e1+2	p.W51_splice	C9orf135_uc011lrw.1_Splice_Site|C9orf135_uc010moq.2_Splice_Site|C9orf135_uc011lrx.1_Splice_Site|C9orf135_uc010mop.2_Splice_Site_p.W51_splice|uc004ahk.2_5'Flank	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255							integral to membrane				ovary(1)	1						GTATTCCTGGTGAGCGAAGTC	0.408													10	39					0	0	0	0	A	72435949	A	A	72435949	5	1	142	1	0	0	0	0	0	0	1	0	2470	1710	59	5	156	5	C9orf135	9	72435949	Splice_Site	SNP	T	TCGA-CR-7371-01A-11D-2012-08	1433457	72435949	68777482	153	26040											
TRPM3	80036	broad.mit.edu	37	chr9	73167807	73167807	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgctctcgtgtttcctccatCggcagcacaggtgctggaat	6	11	11	13	3	1	0	0	0	1	0	5	1	3	1	2	3	2	5	2	3	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:73167807C>T	uc004aid.2	-	23	3735	c.3491G>A	c.(3490-3492)CGA>CAA	p.R1164Q	TRPM3_uc004ahu.2_Missense_Mutation_p.R1006Q|TRPM3_uc004ahv.2_Missense_Mutation_p.R966Q|TRPM3_uc004ahw.2_Missense_Mutation_p.R1036Q|TRPM3_uc004ahx.2_Missense_Mutation_p.R1023Q|TRPM3_uc004ahy.2_Missense_Mutation_p.R1026Q|TRPM3_uc004ahz.2_Missense_Mutation_p.R1013Q|TRPM3_uc004aia.2_Missense_Mutation_p.R1011Q|TRPM3_uc004aib.2_Missense_Mutation_p.R1001Q|TRPM3_uc004aic.2_Missense_Mutation_p.R1164Q	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1189	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TTTCCTCCATCGGCAGCACAG	0.527													24	222					0	0	0	0	T	73167807	T	T	73167807	3	4	142	1	0	0	0	0	1	0	0	0	16654	884	31	1	1644	1	TRPM3	9	73167807	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	731858	73167807	68045624	154	26041											
PRUNE2	158471	broad.mit.edu	37	chr9	79320154	79320154	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatcaccccacgaggcttCagatgagcagatatcttgct	13	9	8	11	1	3	3	2	1	1	2	3	4	3	3	2	1	2	3	2	1	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:79320154C>A	uc010mpk.2	-	8	7160	c.7036G>T	c.(7036-7038)GAA>TAA	p.E2346*	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2346					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CACGAGGCTTCAGATGAGCAG	0.473													32	133					9.65021e-13	2.14021e-12	1	0	A	79320154	A	A	79320154	4	1	142	1	0	0	0	0	0	1	0	0	12703	835	29	2	2278	2	PRUNE2	9	79320154	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	6152347	79320154	61893277	155	26042											
TLE1	7088	broad.mit.edu	37	chr9	84199390	84199390	+	Frame_Shift_Del	DEL	C	-	-																															atgctggctccatagggggtCcgccaagcattgaggaggtt																										TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:84199390delC	uc004aly.2	-	19	2619	c.2178delG	c.(2176-2178)CGGfs	p.R726fs	TLE1_uc004alz.2_Frame_Shift_Del_p.R736fs|TLE1_uc011lsr.1_Frame_Shift_Del_p.R711fs	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	726	WD 5.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						CATAGGGGGTCCGCCAAGCAT	0.453													---	---	---								-	84199390	-	-	84199390	7	5	142	1	0	1	0	1	0	0	0	0	16004	842	30	0	142	0	TLE1	9	84199390	Frame_Shift_Del	DEL	C	TCGA-CR-7371-01A-11D-2012-08	4879236	84199390	57014041	156	26043											
C9orf4	23732	broad.mit.edu	37	chr9	111903626	111903626	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaaatgtaagcttaccctGaatggctggaccccaagcaa	13	8	9	11	0	0	2	0	2	0	0	0	3	0	3	3	2	3	4	3	2	6	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:111903626G>A	uc004bdw.1	-	4	859	c.859C>T	c.(859-861)CAG>TAG	p.Q287*		NM_014334	NP_055149	Q9P0K9	CI004_HUMAN	hypothetical protein LOC23732	287						integral to membrane					0						AGCTTACCCTGAATGGCTGGA	0.433													5	34					0	0	0	0	A	111903626	A	A	111903626	4	1	142	1	0	0	0	0	0	1	0	0	2492	1299	45	2	183	2	C9orf4	9	111903626	Nonsense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	27704236	111903626	29309805	157	26044											
UGCG	7357	broad.mit.edu	37	chr9	114676936	114676936	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaacagccttatagcaagctCccaggtgtctctcttctgaa	11	11	7	12	0	3	1	0	1	3	0	5	1	4	1	2	1	4	2	2	1	5	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:114676936C>T	uc004bft.2	+	2	440	c.150C>T	c.(148-150)CTC>CTT	p.L50L		NM_003358	NP_003349	Q16739	CEGT_HUMAN	ceramide glucosyltransferase	50	Cytoplasmic (Potential).				epidermis development|glucosylceramide biosynthetic process	Golgi membrane|integral to membrane|membrane fraction	ceramide glucosyltransferase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.0433)	Miglustat(DB00419)	ATAGCAAGCTCCCAGGTGTCT	0.368													13	52					0	0	0	0	T	114676936	T	T	114676936	2	4	142	1	0	0	0	0	0	0	0	1	17007	842	30	2		2	UGCG	9	114676936	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	2773310	114676936	26536495	158	26045											
ALAD	210	broad.mit.edu	37	chr9	116155760	116155760	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtagatgaggttggaggcaTtgagggtggtggtggctgtc	6	11	21	3	0	0	3	0	2	0	1	1	4	0	4	0	8	0	4	0	8	1	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:116155760T>C	uc011lxf.1	-	2	282	c.80A>G	c.(79-81)AAT>AGT	p.N27S	ALAD_uc011lxe.1_Missense_Mutation_p.N27S|ALAD_uc004bhl.3_Missense_Mutation_p.M1V	NM_000031	NP_000022	P13716	HEM2_HUMAN	delta-aminolevulinic acid dehydratase	27					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding				0					Aminolevulinic acid(DB00855)	GTTGGAGGCATTGAGGGTGGT	0.547													11	39					0	0	0	0	C	116155760	C	C	116155760	3	2	142	1	0	0	0	0	1	0	0	0	483	1493	52	5	956	5	ALAD	9	116155760	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	1478824	116155760	25057671	159	26046											
DENND1A	57706	broad.mit.edu	37	chr9	126429310	126429310	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcccaagtacttacattctCaggtatgctgggaagttctc	9	14	8	10	0	2	0	1	0	2	0	5	1	3	1	1	2	3	4	1	2	5	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:126429310C>G	uc004bnz.1	-	8	735	c.502G>C	c.(502-504)GAG>CAG	p.E168Q	DENND1A_uc004bny.1_5'UTR|DENND1A_uc011lzm.1_Missense_Mutation_p.E136Q|DENND1A_uc004boa.1_Missense_Mutation_p.E168Q|DENND1A_uc004bob.1_Missense_Mutation_p.E138Q|DENND1A_uc004boc.2_Missense_Mutation_p.E136Q	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	168	DENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						CTTACATTCTCAGGTATGCTG	0.299													5	31					0	0	0	0	G	126429310	G	G	126429310	3	3	142	1	0	0	0	0	1	0	0	0	4448	835	29	2	2694	2	DENND1A	9	126429310	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	10273550	126429310	14784121	160	26047											
SH2D3C	10044	broad.mit.edu	37	chr9	130511596	130511596	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggggcctgaggggctgaCggggctagcaggcttgctac	5	8	18	10	1	0	2	0	2	0	0	0	2	0	2	1	7	3	5	1	7	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:130511596C>A	uc004bsc.2	-	5	1175	c.1033G>T	c.(1033-1035)GTC>TTC	p.V345F	SH2D3C_uc010mxo.2_Missense_Mutation_p.V185F|SH2D3C_uc004bry.2_Missense_Mutation_p.V187F|SH2D3C_uc004brz.3_5'UTR|SH2D3C_uc011mak.1_5'UTR|SH2D3C_uc004bsa.2_Missense_Mutation_p.V188F|SH2D3C_uc004bsb.2_Missense_Mutation_p.V277F	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	345					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						GAGGGGCTGACGGGGCTAGCA	0.657													12	51					0.000978159	0.00186108	1	0	A	130511596	A	A	130511596	3	1	142	1	0	0	0	0	1	0	0	0	14299	536	19	3	1581	3	SH2D3C	9	130511596	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	4082286	130511596	10701835	161	26048											
AIF1L	83543	broad.mit.edu	37	chr9	133993218	133993218	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagatgaagaagatgatctCagaggtgacaggaggggtca	14	6	17	4	0	2	7	2	3	1	4	3	9	2	8	0	5	0	0	0	5	2	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:133993218C>G	uc004cab.1	+	5	383	c.278C>G	c.(277-279)TCA>TGA	p.S93*	AIF1L_uc004cad.1_Nonsense_Mutation_p.S119*|AIF1L_uc004cae.1_Nonsense_Mutation_p.S93*|AIF1L_uc004cac.1_RNA|AIF1L_uc011mce.1_Nonsense_Mutation_p.S98*	NM_031426	NP_113614	Q9BQI0	AIF1L_HUMAN	ionized calcium binding adapter molecule 2	93	EF-hand 2; degenerate.					actin cytoskeleton|cytoplasm|focal adhesion|ruffle membrane	actin filament binding|calcium ion binding				0						AAGATGATCTCAGAGGTGACA	0.507													8	69					0	0	0	0	G	133993218	G	G	133993218	4	3	142	1	0	0	0	0	0	1	0	0	425	838	29	2	378	2	AIF1L	9	133993218	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	3481622	133993218	7220213	162	26049											
BAT2L1	84726	broad.mit.edu	37	chr9	134308156	134308156	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgggacgggatgggcaaacAagcaggatcagcaagaccca	15	2	14	10	2	1	1	1	0	0	1	1	4	1	4	1	4	3	3	1	4	3	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:134308156A>T	uc004can.3	+	2	323	c.268A>T	c.(268-270)AAG>TAG	p.K90*	BAT2L1_uc004cam.1_Nonsense_Mutation_p.K90*	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	90							protein binding				0						ATGGGCAAACAAGCAGGATCA	0.577													7	50					0	0	0	0	T	134308156	T	T	134308156	4	4	142	1	0	0	0	0	0	1	0	0	1322	131	5	5	274	5	BAT2L1	9	134308156	Nonsense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	314938	134308156	6905275	163	26050											
COL5A1	1289	broad.mit.edu	37	chr9	137716625	137716625	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctggagattgagcagatgaaAcggcccctgggcacgcagca	11	5	14	11	2	0	4	0	2	0	2	0	5	0	4	2	3	3	4	2	3	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:137716625A>T	uc004cfe.2	+	62	5260	c.4878A>T	c.(4876-4878)AAA>AAT	p.K1626N	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1626	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGCAGATGAAACGGCCCCTGG	0.632													10	31					0	0	0	0	T	137716625	T	T	137716625	3	4	142	1	0	0	0	0	1	0	0	0	3711	40	2	5	5124	5	COL5A1	9	137716625	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	3408469	137716625	3496806	164	26051											
ABCA2	20	broad.mit.edu	37	chr9	139913671	139913671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgctgcagcctgccctgctCcaggaagctgcggatctccg	5	9	12	15	2	1	0	0	0	1	0	3	2	2	2	4	2	7	4	4	2	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr9:139913671C>T	uc011mem.1	-	10	1658	c.1510G>A	c.(1510-1512)GAG>AAG	p.E504K	ABCA2_uc011mel.1_Missense_Mutation_p.E505K|ABCA2_uc004ckl.1_Missense_Mutation_p.E435K|ABCA2_uc004ckm.1_Missense_Mutation_p.E535K|ABCA2_uc004ckn.1_5'Flank|ABCA2_uc004cko.1_Missense_Mutation_p.E281K	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	504					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CTGCCCTGCTCCAGGAAGCTG	0.652													6	31					0	0	0	0	T	139913671	T	T	139913671	3	4	142	1	0	0	0	0	1	0	0	0	32	864	30	2	5953	2	ABCA2	9	139913671	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	2197046	139913671	1299760	165	26052											
C10orf18	54906	broad.mit.edu	37	chr10	5799599	5799599	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcgtgcaggaggctttgtGatatcagatgacaagatact	11	13	11	6	1	1	4	1	2	0	2	2	5	1	5	0	2	2	2	0	2	3	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:5799599G>A	uc001iij.2	+	17	7474	c.6849G>A	c.(6847-6849)GTG>GTA	p.V2283V	C10orf18_uc001iik.2_Silent_p.V1127V	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2283										ovary(1)|central_nervous_system(1)	2						GAGGCTTTGTGATATCAGATG	0.428													6	155					0	0	0	0	A	5799599	A	A	5799599	2	1	142	1	0	0	0	0	0	0	0	1	1602	1277	45	2		2	C10orf18	10	5799599	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08		5799599	129735148	166	26053											
CELF2	10659	broad.mit.edu	37	chr10	11047378	11047378	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcccaaatccgctgttactAtgagaaatgaagagctgctt	12	11	9	9	1	0	3	0	2	0	2	2	4	2	3	2	0	3	4	2	0	5	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:11047378A>G	uc001iki.3	+	1	120	c.28A>G	c.(28-30)ATG>GTG	p.M10V	CELF2_uc010qbi.1_5'UTR|CELF2_uc010qbj.1_Missense_Mutation_p.M10V	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	10	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						CGCTGTTACTATGAGAAATGA	0.413													6	182					0	0	0	0	G	11047378	G	G	11047378	3	3	142	1	0	0	0	0	1	0	0	0	3231	449	16	5	30	5	CELF2	10	11047378	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	5247779	11047378	124487369	167	26054											
ITGA8	8516	broad.mit.edu	37	chr10	15655677	15655677	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaggcagcagatgtcataGagtctggaacctggcaagtt	12	8	12	9	0	2	2	1	0	1	2	2	3	2	3	2	3	2	4	2	3	3	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:15655677G>C	uc001ioc.1	-	15	1535	c.1535C>G	c.(1534-1536)TCT>TGT	p.S512C	ITGA8_uc010qcb.1_Missense_Mutation_p.S497C	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	512	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						AGATGTCATAGAGTCTGGAAC	0.313													17	112					0	0	0	0	C	15655677	C	C	15655677	3	2	142	1	0	0	0	0	1	0	0	0	7921	942	33	2	1720	2	ITGA8	10	15655677	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	4608299	15655677	119879070	168	26055											
MYO3A	53904	broad.mit.edu	37	chr10	26414348	26414348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcttctttgctttgcattcGggcagatgagctacaagaag	9	13	11	8	1	1	3	0	1	1	2	2	3	1	3	0	1	5	5	0	1	3	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:26414348G>A	uc001isn.2	+	19	2285	c.1925G>A	c.(1924-1926)CGG>CAG	p.R642Q	MYO3A_uc009xko.1_Missense_Mutation_p.R642Q|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	642	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						CTTTGCATTCGGGCAGATGAG	0.418													66	40					0	0	0	0	A	26414348	A	A	26414348	3	1	142	1	0	0	0	0	1	0	0	0	10129	1116	39	1	1991	1	MYO3A	10	26414348	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	10758671	26414348	109120399	169	26056											
PARD3	56288	broad.mit.edu	37	chr10	34420402	34420402	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attacttacccagggttgctCaaaactataggtccgccgac	11	10	8	12	2	1	0	1	0	0	0	2	1	2	0	3	2	4	2	3	2	6	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:34420402C>G	uc010qej.1	-	23	3538	c.3538G>C	c.(3538-3540)GAG>CAG	p.E1180Q	PARD3_uc010qek.1_Missense_Mutation_p.E1177Q|PARD3_uc010qel.1_Missense_Mutation_p.E1143Q|PARD3_uc010qem.1_Missense_Mutation_p.E1164Q|PARD3_uc010qen.1_Missense_Mutation_p.E1134Q|PARD3_uc010qeo.1_Missense_Mutation_p.E1097Q|PARD3_uc010qep.1_Missense_Mutation_p.E1090Q|PARD3_uc010qeq.1_Missense_Mutation_p.E1068Q	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1180					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CAGGGTTGCTCAAAACTATAG	0.458													4	47					0	0	0	0	G	34420402	G	G	34420402	3	3	142	1	0	0	0	0	1	0	0	0	11497	835	29	2	544	2	PARD3	10	34420402	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	8006054	34420402	101114345	170	26057											
PARD3	56288	broad.mit.edu	37	chr10	34420469	34420469	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttgctgaaattcttgcctCagacgctgtatccgatcatg	8	13	9	11	2	3	2	2	1	1	1	4	3	4	2	2	0	2	4	2	0	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:34420469C>G	uc010qej.1	-	23	3471	c.3471G>C	c.(3469-3471)CTG>CTC	p.L1157L	PARD3_uc010qek.1_Silent_p.L1154L|PARD3_uc010qel.1_Silent_p.L1120L|PARD3_uc010qem.1_Silent_p.L1141L|PARD3_uc010qen.1_Silent_p.L1111L|PARD3_uc010qeo.1_Silent_p.L1074L|PARD3_uc010qep.1_Silent_p.L1067L|PARD3_uc010qeq.1_Silent_p.L1045L	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1157	Potential.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				ATTCTTGCCTCAGACGCTGTA	0.433													9	62					0	0	0	0	G	34420469	G	G	34420469	2	3	142	1	0	0	0	0	0	0	0	1	11497	813	29	2		2	PARD3	10	34420469	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	67	34420469	101114278	171	26058											
ANKRD30A	91074	broad.mit.edu	37	chr10	37440991	37440991	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgattaaccttttatagatcCgatgttcccaccagaatcca	12	13	5	11	1	0	3	0	1	0	2	3	4	3	3	5	0	1	1	5	0	4	5	rs45515098		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:37440991C>T	uc001iza.1	+	12	1580	c.1481C>T	c.(1480-1482)CCG>CTG	p.P494L		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	550						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TTTATAGATCCGATGTTCCCA	0.294													9	43					0	0	0	0	T	37440991	T	T	37440991	3	4	142	1	0	0	0	0	1	0	0	0	658	652	23	1	1527	1	ANKRD30A	10	37440991	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	3020522	37440991	98093756	172	26059											
ZNF33A	7581	broad.mit.edu	37	chr10	38344884	38344884	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggggagaaaccctatgaatGtaatgaatgtggaaaagcct	16	8	12	5	0	0	3	0	2	0	1	0	5	0	4	2	3	2	1	2	3	7	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:38344884G>A	uc001izh.2	+	5	2007	c.1829G>A	c.(1828-1830)TGT>TAT	p.C610Y	ZNF33A_uc001izg.2_Missense_Mutation_p.C611Y|ZNF33A_uc010qev.1_Missense_Mutation_p.C617Y|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	610	C2H2-type 11.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						CCCTATGAATGTAATGAATGT	0.363													11	58					0	0	0	0	A	38344884	A	A	38344884	3	1	142	1	0	0	0	0	1	0	0	0	17921	1377	48	4	1846	4	ZNF33A	10	38344884	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	903893	38344884	97189863	173	26060											
CSGALNACT2	55454	broad.mit.edu	37	chr10	43654256	43654256	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagacatgtgaccctcttccGcccttttggacctctcatga	7	13	7	14	1	2	3	1	2	2	1	4	4	3	4	4	1	0	0	4	1	1	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:43654256G>T	uc001jan.2	+	3	1090	c.755G>T	c.(754-756)CGC>CTC	p.R252L	CSGALNACT2_uc001jam.1_Missense_Mutation_p.R252L	NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	252	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						ACCCTCTTCCGCCCTTTTGGA	0.393													11	50					3.07112e-06	6.11685e-06	1	0	T	43654256	T	T	43654256	3	4	142	1	0	0	0	0	1	0	0	0	3956	1087	38	3	761	3	CSGALNACT2	10	43654256	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	5309372	43654256	91880491	174	26061											
ANK3	288	broad.mit.edu	37	chr10	61815535	61815535	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacacagggtttagtctcttCtattataagcttgctggttt	8	17	8	8	0	2	0	0	0	2	0	3	0	2	0	0	2	2	4	0	2	4	8			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:61815535C>G	uc001jky.2	-	42	13138	c.12946G>C	c.(12946-12948)GAA>CAA	p.E4316Q	ANK3_uc001jkw.2_Missense_Mutation_p.E940Q|ANK3_uc009xpa.2_Missense_Mutation_p.E940Q|ANK3_uc001jkx.2_Missense_Mutation_p.E984Q|ANK3_uc010qih.1_Missense_Mutation_p.E1807Q|ANK3_uc001jkz.3_Missense_Mutation_p.E1800Q|ANK3_uc001jkv.2_Missense_Mutation_p.E339Q	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	4316					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTAGTCTCTTCTATTATAAGC	0.438													6	218					0	0	0	0	G	61815535	G	G	61815535	3	3	142	1	0	0	0	0	1	0	0	0	622	922	32	2	195	2	ANK3	10	61815535	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	18161279	61815535	73719212	175	26062											
AGAP5	729092	broad.mit.edu	37	chr10	75457410	75457410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgccatcctgtccccagctCctgcctcatagatctcagat	7	11	6	17	0	2	2	2	0	1	2	6	2	5	2	6	0	3	1	6	0	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:75457410C>T	uc009xri.2	-	1	145	c.104G>A	c.(103-105)GGA>GAA	p.G35E	AGAP5_uc001juu.3_5'UTR	NM_001144000	NP_001137472	A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	35					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						GTCCCCAGCTCCTGCCTCATA	0.582													21	152					0	0	0	0	T	75457410	T	T	75457410	3	4	142	1	0	0	0	0	1	0	0	0	371	855	30	2	1988	2	AGAP5	10	75457410	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	13641875	75457410	60077337	176	26063											
WAPAL	23063	broad.mit.edu	37	chr10	88232004	88232004	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaggctgagtgctctttaagCcacttaacaagtactcaatg	12	11	9	9	0	2	1	1	1	1	0	2	2	2	1	1	1	4	3	1	1	5	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:88232004C>G	uc001kdo.2	-	7	2433	c.1991G>C	c.(1990-1992)GGC>GCC	p.G664A	WAPAL_uc009xsv.2_5'Flank|WAPAL_uc001kdn.2_Missense_Mutation_p.G701A|WAPAL_uc009xsw.2_Missense_Mutation_p.G658A	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	664	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						GCTCTTTAAGCCACTTAACAA	0.343													4	41					0	0	0	0	G	88232004	G	G	88232004	3	3	142	1	0	0	0	0	1	0	0	0	17316	739	26	4	1633	4	WAPAL	10	88232004	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	12774594	88232004	47302743	177	26064											
ABLIM1	3983	broad.mit.edu	37	chr10	116444079	116444079	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcccatggtgtgatgagggtCcgtgagctcagtcatttcca	7	12	12	10	1	2	3	2	3	0	0	5	3	5	3	3	2	1	1	3	2	0	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:116444079C>A	uc010qsh.1	-	1	336	c.34G>T	c.(34-36)GAC>TAC	p.D12Y	ABLIM1_uc010qsi.1_Missense_Mutation_p.D12Y|ABLIM1_uc009xyp.2_Missense_Mutation_p.D6Y|ABLIM1_uc001lbz.1_Intron	NM_001003408	NP_001003408	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform c	Error:Variant_position_missing_in_O14639_after_alignment					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		TGATGAGGGTCCGTGAGCTCA	0.468													12	62					3.27435e-08	6.78326e-08	1	0	A	116444079	A	A	116444079	3	1	142	1	0	0	0	0	1	0	0	0	94	855	30	2	2546	2	ABLIM1	10	116444079	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	28212075	116444079	19090668	178	26065											
KCNK18	338567	broad.mit.edu	37	chr10	118969465	118969465	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatcatcagcaacctggaTgaagttggacagcaggtgga	12	8	12	9	0	2	1	2	1	0	0	3	4	3	4	2	4	3	3	2	4	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:118969465T>C	uc010qsr.1	+	3	810	c.810T>C	c.(808-810)GAT>GAC	p.D270D		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	270	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		GCAACCTGGATGAAGTTGGAC	0.527													18	93					0	0	0	0	C	118969465	C	C	118969465	2	2	142	1	0	0	0	0	0	0	0	1	8104	1461	51	5		5	KCNK18	10	118969465	Silent	SNP	T	TCGA-CR-7371-01A-11D-2012-08	2525386	118969465	16565282	179	26066											
RAB11FIP2	22841	broad.mit.edu	37	chr10	119768713	119768713	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagactacgataccctgcAgtggcatcaaaggggttgct	10	9	12	10	1	2	1	2	0	0	1	2	2	2	1	1	3	4	4	1	3	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:119768713A>T	uc001ldj.1	-	5	1775	c.1335T>A	c.(1333-1335)ACT>ACA	p.T445T	RAB11FIP2_uc009xyz.1_Silent_p.T465T	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	445	FIP-RBD.				protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		GATACCCTGCAGTGGCATCAA	0.458													25	73					0	0	0	0	T	119768713	T	T	119768713	2	4	142	1	0	0	0	0	0	0	0	1	12959	175	7	5		5	RAB11FIP2	10	119768713	Silent	SNP	A	TCGA-CR-7371-01A-11D-2012-08	799248	119768713	15766034	180	26067											
WDR11	55717	broad.mit.edu	37	chr10	122618278	122618278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcaggagtagctcagtgtGagatccaagagcatgccaag	13	6	13	9	0	1	2	1	1	0	2	2	4	2	3	2	1	4	4	2	1	3	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr10:122618278G>A	uc010qtf.1	+	3	560	c.322G>A	c.(322-324)GAG>AAG	p.E108K	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	108	WD 1.					integral to membrane					0						AGCTCAGTGTGAGATCCAAGA	0.458													6	41					0	0	0	0	A	122618278	A	A	122618278	3	1	142	1	0	0	0	0	1	0	0	0	17341	1291	45	2	332	2	WDR11	10	122618278	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	2849565	122618278	12916469	181	26068											
OR51G1	79324	broad.mit.edu	37	chr11	4945474	4945474	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcaggtagatgaagcagaaGggaatagagatccagccatg	15	6	14	6	0	1	4	1	1	0	3	2	6	2	5	2	2	2	2	2	2	5	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:4945474G>T	uc010qyr.1	-	1	96	c.96C>A	c.(94-96)CCC>CCA	p.P32P		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAAGCAGAAGGGAATAGAGA	0.468													11	50					1.33987e-11	2.91785e-11	1	0	T	4945474	T	T	4945474	2	4	142	1	0	0	0	0	0	0	0	1	11152	987	35	4		4	OR51G1	11	4945474	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08		4945474	130061042	182	26069											
TRIM6-TRIM34	445372	broad.mit.edu	37	chr11	5653889	5653889	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aactcctactcttctgtaagGaggataggaaagtcatttgc	12	12	9	8	0	3	0	1	0	2	0	4	3	4	3	1	3	3	1	1	3	5	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:5653889G>T	uc001mbf.2	+	8	1634	c.1390G>T	c.(1390-1392)GAG>TAG	p.E464*	HBG2_uc001mak.1_Intron|TRIM34_uc001mbh.2_Nonsense_Mutation_p.E110*|TRIM34_uc009yeq.2_5'UTR|TRIM34_uc001mbi.2_Nonsense_Mutation_p.E110*|TRIM34_uc001mbj.2_Nonsense_Mutation_p.E110*	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	464						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		CTTCTGTAAGGAGGATAGGAA	0.493													4	23					0.00024832	0.000477488	1	0	T	5653889	T	T	5653889	4	4	142	1	0	0	0	0	0	1	0	0	16601	1175	41	2	1420	2	TRIM6-TRIM34	11	5653889	Nonsense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	708415	5653889	129352627	183	26070											
OR52E6	390078	broad.mit.edu	37	chr11	5862952	5862952	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcagtagtacatgggcTcatggagactctgctcagtt	9	10	12	10	0	3	1	2	0	1	1	3	2	3	1	1	3	2	6	1	3	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:5862952T>A	uc010qzq.1	-	1	176	c.176A>T	c.(175-177)GAG>GTG	p.E59V	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTACATGGGCTCATGGAGACT	0.463													17	98					0	0	0	0	A	5862952	A	A	5862952	3	1	142	1	0	0	0	0	1	0	0	0	11171	1551	54	5	767	5	OR52E6	11	5862952	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	209063	5862952	129143564	184	26071											
OR2D2	120776	broad.mit.edu	37	chr11	6913477	6913477	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgaccttctttctggaaagCaggtggactagtgcctgagg	9	11	13	8	0	2	2	0	2	2	0	2	4	2	4	2	4	2	1	2	4	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:6913477C>A	uc010rau.1	-	1	255	c.255G>T	c.(253-255)CTG>CTT	p.L85L		NM_003700	NP_003691	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TTCTGGAAAGCAGGTGGACTA	0.468													9	52					0.000274275	0.000525997	1	0	A	6913477	A	A	6913477	2	1	142	1	0	0	0	0	0	0	0	1	11048	697	25	4		4	OR2D2	11	6913477	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1050525	6913477	128093039	185	26072											
NLRP14	338323	broad.mit.edu	37	chr11	7064307	7064307	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagataagaggtgggccatGaaagtattcagttcactaaa	16	9	11	5	0	2	3	2	1	0	2	2	4	2	3	1	2	0	2	1	2	6	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:7064307G>A	uc001mfb.1	+	4	1373	c.1050G>A	c.(1048-1050)ATG>ATA	p.M350I		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	350	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GGTGGGCCATGAAAGTATTCA	0.428													15	87					0	0	0	0	A	7064307	A	A	7064307	3	1	142	1	0	0	0	0	1	0	0	0	10530	1290	45	2	1060	2	NLRP14	11	7064307	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	150830	7064307	127942209	186	26073											
OR10A3	26496	broad.mit.edu	37	chr11	7960962	7960962	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttcccatcagggtcaccaCataaataactaggaaaaccc	16	8	5	12	0	2	0	2	0	0	0	3	1	3	1	3	2	2	0	3	2	6	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:7960962C>T	uc010rbi.1	-	1	106	c.106G>A	c.(106-108)GTG>ATG	p.V36M		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGGGTCACCACATAAATAACT	0.458													16	43					0	0	0	0	T	7960962	T	T	7960962	3	4	142	1	0	0	0	0	1	0	0	0	10945	478	17	4	841	4	OR10A3	11	7960962	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	896655	7960962	127045554	187	26074											
ABCC8	6833	broad.mit.edu	37	chr11	17482165	17482165	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggaccaggcgcctcccgaagGcatggctgagtgcctgccag	7	5	15	14	2	0	1	0	1	0	0	1	3	1	2	5	4	2	2	5	4	1	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:17482165G>T	uc001mnc.2	-	6	1007	c.881C>A	c.(880-882)GCC>GAC	p.A294D	ABCC8_uc010rcy.1_Missense_Mutation_p.A293D	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	294	Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CCTCCCGAAGGCATGGCTGAG	0.642													14	73					3.45872e-05	6.75852e-05	1	0	T	17482165	T	T	17482165	3	4	142	1	0	0	0	0	1	0	0	0	58	1203	42	4	4000	4	ABCC8	11	17482165	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	9521203	17482165	117524351	188	26075											
IGSF22	283284	broad.mit.edu	37	chr11	18741305	18741305	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctctttgagcttcctgagCagcccccgaaagtcggtgaa	9	10	10	12	2	1	3	0	3	1	0	4	4	2	3	3	1	3	2	3	1	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:18741305C>A	uc009yht.2	-	7	844	c.654G>T	c.(652-654)CTG>CTT	p.L218L	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	218	Lys-rich.									ovary(4)|large_intestine(2)|kidney(1)	7						GCTTCCTGAGCAGCCCCCGAA	0.517													19	158					1.01871e-10	2.17265e-10	1	0	A	18741305	A	A	18741305	2	1	142	1	0	0	0	0	0	0	0	1	7639	697	25	4		4	IGSF22	11	18741305	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1259140	18741305	116265211	189	26076											
SLC6A5	9152	broad.mit.edu	37	chr11	20639323	20639323	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgctgaagatttctgcaGggattgaatatcctggcgag	9	13	13	6	1	1	3	0	2	1	1	2	5	2	4	1	2	2	2	1	2	3	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:20639323G>T	uc001mqd.2	+	7	1426	c.1153G>T	c.(1153-1155)GGG>TGG	p.G385W	SLC6A5_uc009yic.2_Missense_Mutation_p.G150W	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	385	Extracellular (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	GATTTCTGCAGGGATTGAATA	0.368													10	89					0.000978159	0.00186108	1	0	T	20639323	T	T	20639323	3	4	142	1	0	0	0	0	1	0	0	0	14751	1000	35	4	1179	4	SLC6A5	11	20639323	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1898018	20639323	114367193	190	26077											
FBXO3	26273	broad.mit.edu	37	chr11	33768856	33768856	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccgacctgggctgatgatTggaaattcacctgcagggaa	11	8	12	10	1	1	2	1	2	0	0	1	5	1	4	3	3	1	2	3	3	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:33768856T>C	uc001muz.2	-	10	1087	c.1059A>G	c.(1057-1059)CCA>CCG	p.P353P	FBXO3_uc010rej.1_Silent_p.P40P|FBXO3_uc001muy.2_Silent_p.P240P|FBXO3_uc009ykb.2_RNA|FBXO3_uc001mva.1_Silent_p.P353P|FBXO3_uc001mvb.1_Silent_p.P348P|FBXO3_uc010rek.1_RNA	NM_012175	NP_036307	Q9UK99	FBX3_HUMAN	F-box only protein 3 isoform 1	353	ApaG.				proteolysis	nucleus	ubiquitin-protein ligase activity			pancreas(1)	1		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		GGCTGATGATTGGAAATTCAC	0.343													14	35					0	0	0	0	C	33768856	C	C	33768856	2	2	142	1	0	0	0	0	0	0	0	1	5771	1799	63	5		5	FBXO3	11	33768856	Silent	SNP	T	TCGA-CR-7371-01A-11D-2012-08	13129533	33768856	101237660	191	26078											
HARBI1	283254	broad.mit.edu	37	chr11	46637351	46637351	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catggatacagtcaaccaccCccatcacccctggcatccct	10	7	5	19	0	2	0	2	0	0	0	3	1	3	1	6	2	2	1	6	2	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:46637351C>G	uc001ncy.2	-	2	685	c.437G>C	c.(436-438)GGG>GCG	p.G146A	KIAA0652_uc009yld.2_5'Flank|KIAA0652_uc001nda.2_5'Flank|KIAA0652_uc001ndb.2_5'Flank|KIAA0652_uc001ncz.2_5'Flank|KIAA0652_uc001ndc.2_5'Flank|KIAA0652_uc010rgv.1_5'Flank	NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	146						cytoplasm|nucleus	metal ion binding|nuclease activity				0						GTCAACCACCCCCATCACCCC	0.512													46	195					0	0	0	0	G	46637351	G	G	46637351	3	3	142	1	0	0	0	0	1	0	0	0	6997	623	22	4	620	4	HARBI1	11	46637351	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	12868495	46637351	88369165	192	26079											
OR4C15	81309	broad.mit.edu	37	chr11	55322242	55322242	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgaaggctgcatgatgcagCtctttgctgaacacttcttt	8	15	9	9	0	2	3	0	3	2	0	2	3	2	3	0	1	5	5	0	1	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:55322242C>A	uc010rig.1	+	1	460	c.460C>A	c.(460-462)CTC>ATC	p.L154I		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	100	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CATGATGCAGCTCTTTGCTGA	0.478										HNSCC(20;0.049)			29	110					1.2476e-16	2.85447e-16	1	0	A	55322242	A	A	55322242	3	1	142	1	0	0	0	0	1	0	0	0	11102	797	28	4	462	4	OR4C15	11	55322242	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	8684891	55322242	79684274	193	26080											
OR4C15	81309	broad.mit.edu	37	chr11	55322833	55322833	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaggaagtaaaacaggccAtgaggagaatatggaacaga	20	5	12	4	0	0	3	0	1	0	2	0	6	0	5	1	4	2	1	1	4	7	3	rs112163324		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:55322833A>T	uc010rig.1	+	1	1051	c.1051A>T	c.(1051-1053)ATG>TTG	p.M351L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AAAACAGGCCATGAGGAGAAT	0.333										HNSCC(20;0.049)			9	55					0	0	0	0	T	55322833	T	T	55322833	3	4	142	1	0	0	0	0	1	0	0	0	11102	217	8	5	1053	5	OR4C15	11	55322833	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	591	55322833	79683683	194	26081											
OR8K3	219473	broad.mit.edu	37	chr11	56086330	56086330	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctactgtgacagtctccCtttgttacctttgctttgtt	4	21	6	10	0	2	1	0	1	2	0	3	1	2	1	2	0	3	3	2	0	2	7			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:56086330C>A	uc010rjf.1	+	1	548	c.548C>A	c.(547-549)CCT>CAT	p.P183H		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					GACAGTCTCCCTTTGTTACCT	0.328													18	77					5.35267e-07	1.081e-06	1	0	A	56086330	A	A	56086330	3	1	142	1	0	0	0	0	1	0	0	0	11298	681	24	4	550	4	OR8K3	11	56086330	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	763497	56086330	78920186	195	26082											
P2RX3	5024	broad.mit.edu	37	chr11	57118259	57118259	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggagttctgggcattaagatCggctgggtgtgcgacttgga	7	11	17	6	2	1	1	0	0	1	1	2	4	1	3	0	5	1	3	0	5	1	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:57118259C>T	uc001nju.2	+	8	805	c.729C>T	c.(727-729)ATC>ATT	p.I243I		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	243	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GCATTAAGATCGGCTGGGTGT	0.622													4	26					0	0	0	0	T	57118259	T	T	57118259	2	4	142	1	0	0	0	0	0	0	0	1	11395	874	31	1		1	P2RX3	11	57118259	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1031929	57118259	77888257	196	26083											
OR4D11	219986	broad.mit.edu	37	chr11	59271774	59271774	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccatctccacttgcacctcCcacatcactgtggtgaccct	7	10	6	18	0	2	1	1	1	1	0	4	1	3	1	5	1	1	1	5	1	0	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:59271774C>T	uc001noa.1	+	1	726	c.726C>T	c.(724-726)TCC>TCT	p.S242S		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTTGCACCTCCCACATCACTG	0.547													28	160					0	0	0	0	T	59271774	T	T	59271774	2	4	142	1	0	0	0	0	0	0	0	1	11109	610	22	4		4	OR4D11	11	59271774	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	2153515	59271774	75734742	197	26084											
MS4A5	64232	broad.mit.edu	37	chr11	60215208	60215208	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttggggtgccactcagaggaTtgtgattgtgaacaatgttg	9	13	14	5	0	1	3	1	2	0	1	1	4	1	4	1	3	2	1	1	3	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:60215208T>C	uc001npo.2	+	5	665	c.579T>C	c.(577-579)GAT>GAC	p.D193D		NM_023945	NP_076434	Q9H3V2	MS4A5_HUMAN	membrane-spanning 4-domains, subfamily A, member	193	Cytoplasmic (Potential).					integral to membrane	receptor activity			large_intestine(1)|ovary(1)	2						ACTCAGAGGATTGTGATTGTG	0.353													16	88					0	0	0	0	C	60215208	C	C	60215208	2	2	142	1	0	0	0	0	0	0	0	1	9916	1490	52	5		5	MS4A5	11	60215208	Silent	SNP	T	TCGA-CR-7371-01A-11D-2012-08	943434	60215208	74791308	198	26085											
SART1	9092	broad.mit.edu	37	chr11	65744017	65744017	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacgggctggctggcaatcGcgaggagcaggaggagctca	9	5	17	10	3	1	0	1	0	0	0	2	4	1	3	0	6	3	5	0	6	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:65744017G>A	uc001ogl.2	+	13	1816	c.1724G>A	c.(1723-1725)CGC>CAC	p.R575H		NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	575					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1						GCTGGCAATCGCGAGGAGCAG	0.687													8	39					0	0	0	0	A	65744017	A	A	65744017	3	1	142	1	0	0	0	0	1	0	0	0	13911	1087	38	1	1774	1	SART1	11	65744017	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	5528809	65744017	69262499	199	26086											
SPTBN2	6712	broad.mit.edu	37	chr11	66454925	66454925	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccttcttcccgaaggccTccatctcctgcttgcggcac	5	10	8	18	2	2	0	0	0	2	0	5	1	4	0	5	2	3	2	5	2	1	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:66454925T>C	uc001ojd.2	-	34	6767	c.6695A>G	c.(6694-6696)GAG>GGG	p.E2232G	SPTBN2_uc001ojc.1_Missense_Mutation_p.R93G	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	2232	PH.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCCGAAGGCCTCCATCTCCTG	0.642													3	93					0	0	0	0	C	66454925	C	C	66454925	3	2	142	1	0	0	0	0	1	0	0	0	15186	1551	54	5	493	5	SPTBN2	11	66454925	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	710908	66454925	68551591	200	26087											
UVRAG	7405	broad.mit.edu	37	chr11	75851885	75851885	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgaaaacgggccagctctGagaatgagagacttcagtac	14	7	11	9	2	2	3	1	2	1	2	3	6	2	3	1	1	3	2	1	1	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:75851885G>A	uc001oxc.2	+	15	1769	c.1528G>A	c.(1528-1530)GAG>AAG	p.E510K	UVRAG_uc010rrw.1_Missense_Mutation_p.E409K|UVRAG_uc001oxd.2_Missense_Mutation_p.E138K|UVRAG_uc010rrx.1_Missense_Mutation_p.E138K|UVRAG_uc010rry.1_Missense_Mutation_p.E66K	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	510					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						GGCCAGCTCTGAGAATGAGAG	0.527													7	104					0	0	0	0	A	75851885	A	A	75851885	3	1	142	1	0	0	0	0	1	0	0	0	17176	1291	45	2	1586	2	UVRAG	11	75851885	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	9396960	75851885	59154631	201	26088											
AQP11	282679	broad.mit.edu	37	chr11	77301379	77301379	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctggggggcatgtccccCgagacgggtgcggtgaggct	5	7	19	10	3	0	2	0	1	0	1	1	3	1	2	2	6	2	3	2	6	0	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:77301379C>A	uc001oyj.2	+	1	700	c.342C>A	c.(340-342)CCC>CCA	p.P114P	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	114						cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			GCATGTCCCCCGAGACGGGTG	0.607													15	83					1.45105e-14	3.27847e-14	1	0	A	77301379	A	A	77301379	2	1	142	1	0	0	0	0	0	0	0	1	823	639	23	3		3	AQP11	11	77301379	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1449494	77301379	57705137	202	26089											
DLG2	1740	broad.mit.edu	37	chr11	83673932	83673932	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaggcatatctgacctggTgtagtcgtcgtcaacaagca	12	9	10	10	2	2	1	1	1	1	0	4	1	2	1	1	2	3	3	1	2	5	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:83673932T>G	uc001paj.2	-	9	1324	c.1021A>C	c.(1021-1023)ACC>CCC	p.T341P	DLG2_uc001pai.2_Missense_Mutation_p.T290P|DLG2_uc010rsy.1_Missense_Mutation_p.T308P|DLG2_uc010rsz.1_Missense_Mutation_p.T341P|DLG2_uc010rta.1_Missense_Mutation_p.T341P|DLG2_uc001pak.2_Missense_Mutation_p.T446P|DLG2_uc010rtb.1_Missense_Mutation_p.T308P|DLG2_uc001pal.1_Missense_Mutation_p.T341P|DLG2_uc001pam.1_Missense_Mutation_p.T380P	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	341						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCTGACCTGGTGTAGTCGTCG	0.418													4	218					0	0	0	0	G	83673932	G	G	83673932	3	3	142	1	0	0	0	0	1	0	0	0	4577	1696	59	5	1701	5	DLG2	11	83673932	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	6372553	83673932	51332584	203	26090											
KBTBD3	143879	broad.mit.edu	37	chr11	105924580	105924580	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagagtccaccagaacctTgcacacacttaattgcatcc	13	8	7	13	0	0	2	0	0	0	2	2	3	2	3	4	1	3	2	4	1	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:105924580T>G	uc001pja.2	-	4	1476	c.836A>C	c.(835-837)CAA>CCA	p.Q279P	KBTBD3_uc001pjb.2_Missense_Mutation_p.Q279P|KBTBD3_uc009yxm.2_Missense_Mutation_p.Q200P	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	275										ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		ACCAGAACCTTGCACACACTT	0.378													4	54					0	0	0	0	G	105924580	G	G	105924580	3	3	142	1	0	0	0	0	1	0	0	0	8033	1812	63	5	1006	5	KBTBD3	11	105924580	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	22250648	105924580	29081936	204	26091											
HSPA8	3312	broad.mit.edu	37	chr11	122930370	122930370	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tactgggtccagggtgccacGgaacaggtcagcattcagtt	9	9	13	10	1	2	0	2	0	0	0	3	1	3	1	2	4	4	2	2	4	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:122930370G>A	uc001pyo.2	-	5	1009	c.931C>T	c.(931-933)CGT>TGT	p.R311C	HSPA8_uc009zbc.2_Missense_Mutation_p.R75C|HSPA8_uc001pyp.2_Missense_Mutation_p.R311C|HSPA8_uc010rzu.1_Missense_Mutation_p.R234C|HSPA8_uc009zbd.1_Missense_Mutation_p.R311C	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	311	Interaction with BAG1.				cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGGGTGCCACGGAACAGGTCA	0.488													17	39					0	0	0	0	A	122930370	A	A	122930370	3	1	142	1	0	0	0	0	1	0	0	0	7455	1116	39	1	1029	1	HSPA8	11	122930370	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	17005790	122930370	12076146	205	26092											
OR8B2	26595	broad.mit.edu	37	chr11	124252330	124252330	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcctctgaattttaatcaGagctttcctcagtgcaactt	9	16	5	11	0	4	2	2	1	2	1	6	2	5	2	2	0	3	2	2	0	3	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:124252330G>A	uc010sai.1	-	1	910	c.910C>T	c.(910-912)CTG>TTG	p.L304L		NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		ATTTTAATCAGAGCTTTCCTC	0.338													16	37					0	0	0	0	A	124252330	A	A	124252330	2	1	142	1	0	0	0	0	0	0	0	1	11281	933	33	2		2	OR8B2	11	124252330	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1321960	124252330	10754186	206	26093											
STT3A	3703	broad.mit.edu	37	chr11	125484217	125484217	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattgtacatttgtttttccAggcaatggcgtccacagagg	10	13	10	8	1	0	1	0	0	0	1	2	1	2	1	2	3	1	3	2	3	3	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:125484217A>G	uc001qcd.2	+	15	1782	c.1672_splice	c.e15-2	p.A558_splice	STT3A_uc001qce.2_Splice_Site_p.A558_splice|STT3A_uc010sbg.1_Splice_Site_p.A466_splice|STT3A_uc009zbn.2_Splice_Site_p.A280_splice	NM_152713	NP_689926	P46977	STT3A_HUMAN	integral membrane protein 1						post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		TTGTTTTTCCAGGCAATGGCG	0.453													19	222					0	0	0	0	G	125484217	G	G	125484217	5	3	142	1	0	0	0	0	0	0	1	0	15399	202	7	5	1724	5	STT3A	11	125484217	Splice_Site	SNP	A	TCGA-CR-7371-01A-11D-2012-08	1231887	125484217	9522299	207	26094											
ADAMTS15	170689	broad.mit.edu	37	chr11	130318901	130318901	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcatcctaaccctggctttCgccgggcgaaccgctggagg	6	7	14	14	4	0	0	0	0	0	0	2	2	1	1	4	5	2	3	4	5	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr11:130318901C>T	uc010scd.1	+	1	33	c.33C>T	c.(31-33)TTC>TTT	p.F11F		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	11					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CCCTGGCTTTCGCCGGGCGAA	0.711													4	29					0	0	0	0	T	130318901	T	T	130318901	2	4	142	1	0	0	0	0	0	0	0	1	260	883	31	1		1	ADAMTS15	11	130318901	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	4834684	130318901	4687615	208	26095											
CLEC4E	26253	broad.mit.edu	37	chr12	8691819	8691819	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggactattatacctgatcCataattgtagcaggagagct	12	12	10	7	0	0	2	0	1	0	1	1	4	1	3	2	2	3	3	2	2	5	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:8691819C>A	uc001quo.1	-	3	379	c.214G>T	c.(214-216)GGA>TGA	p.G72*		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	72	Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					ATACCTGATCCATAATTGTAG	0.383													16	108					2.23348e-06	4.47316e-06	1	0	A	8691819	A	A	8691819	4	1	142	1	0	0	0	0	0	1	0	0	3530	603	21	4	461	4	CLEC4E	12	8691819	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08		8691819	125160076	209	26096											
KLRF1	51348	broad.mit.edu	37	chr12	9984956	9984956	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaaatcttactgggaataTctggaaccgtgaatggtatt	14	13	9	5	1	2	1	0	1	2	0	2	3	2	3	1	3	2	1	1	3	8	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:9984956T>C	uc010sgw.1	+	2	194	c.130T>C	c.(130-132)TCT>CCT	p.S44P	KLRF1_uc009zgw.2_Missense_Mutation_p.S44P|KLRF1_uc009zgx.2_RNA|KLRF1_uc001qwm.2_RNA|KLRF1_uc009zgy.2_RNA|KLRF1_uc009zgz.2_Missense_Mutation_p.S44P|KLRF1_uc009zha.2_RNA	NM_016523	NP_057607	Q9NZS2	KLRF1_HUMAN	killer cell lectin-like receptor subfamily F,	44	Helical; Signal-anchor for type II membrane protein; (Potential).				cell surface receptor linked signaling pathway	integral to plasma membrane	MHC class I receptor activity|sugar binding			large_intestine(1)	1						ACTGGGAATATCTGGAACCGT	0.323													9	28					0	0	0	0	C	9984956	C	C	9984956	3	2	142	1	0	0	0	0	1	0	0	0	8459	1435	50	5	136	5	KLRF1	12	9984956	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	1293137	9984956	123866939	210	26097											
ETV6	2120	broad.mit.edu	37	chr12	12022820	12022820	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccatcaacctctctcatcGggaagacctggcttacatga	10	9	8	14	1	3	2	2	1	1	1	5	3	3	3	3	2	2	1	3	2	3	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:12022820G>T	uc001qzz.2	+	5	1200	c.926G>T	c.(925-927)CGG>CTG	p.R309L	ETV6_uc001raa.1_Missense_Mutation_p.R102L	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	309						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CTCTCTCATCGGGAAGACCTG	0.577			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								23	98					1.55469e-16	3.54588e-16	1	0	T	12022820	T	T	12022820	3	4	142	1	0	0	0	0	1	0	0	0	5307	1116	39	3	944	3	ETV6	12	12022820	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	2037864	12022820	121829075	211	26098											
GRIN2B	2904	broad.mit.edu	37	chr12	14018815	14018815	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaaatgaaatcgaggatctGggcgatggcttcctggtctg	9	11	14	7	2	2	2	0	2	2	0	4	5	3	3	1	4	0	1	1	4	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:14018815G>T	uc001rbt.2	-	2	507	c.328C>A	c.(328-330)CAG>AAG	p.Q110K		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	110	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCGAGGATCTGGGCGATGGCT	0.542													23	86					5.26018e-13	1.1738e-12	1	0	T	14018815	T	T	14018815	3	4	142	1	0	0	0	0	1	0	0	0	6819	1357	47	4	4174	4	GRIN2B	12	14018815	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1995995	14018815	119833080	212	26099											
C12orf40	283461	broad.mit.edu	37	chr12	40076630	40076630	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgtgactcttttgttagtCaaaatatgatcaatgtatta	13	18	6	4	0	3	2	2	2	1	0	3	2	3	2	0	0	0	2	0	0	7	7			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:40076630C>A	uc001rmc.2	+	8	1071	c.904C>A	c.(904-906)CAA>AAA	p.Q302K	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	302										ovary(6)	6						TTTTGTTAGTCAAAATATGAT	0.323													18	53					1.99824e-07	4.06965e-07	1	0	A	40076630	A	A	40076630	3	1	142	1	0	0	0	0	1	0	0	0	1692	827	29	2	934	2	C12orf40	12	40076630	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	26057815	40076630	93775265	213	26100											
LMBR1L	55716	broad.mit.edu	37	chr12	49495950	49495950	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagggggtagcccaggttccGttgccaggctgaagccttcc	6	8	14	13	1	0	1	0	1	0	0	2	1	2	1	5	4	3	4	5	4	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:49495950G>A	uc001rth.3	-	11	1225	c.883C>T	c.(883-885)CGG>TGG	p.R295W	LMBR1L_uc001rtg.3_Missense_Mutation_p.R290W|LMBR1L_uc001rti.3_Missense_Mutation_p.R295W|LMBR1L_uc001rtj.1_Missense_Mutation_p.R139W|LMBR1L_uc009zld.1_Missense_Mutation_p.R168W	NM_018113	NP_060583	Q6UX01	LMBRL_HUMAN	lipocalin-interacting membrane receptor	295	Cytoplasmic (Potential).				endocytosis	integral to membrane|plasma membrane	receptor activity			pancreas(1)	1						CCCAGGTTCCGTTGCCAGGCT	0.597													11	63					0	0	0	0	A	49495950	A	A	49495950	3	1	142	1	0	0	0	0	1	0	0	0	8883	1144	40	1	614	1	LMBR1L	12	49495950	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	9419320	49495950	84355945	214	26101											
DGKA	1606	broad.mit.edu	37	chr12	56332340	56332340	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagaaatgggatcctggacaGctcagtgagttggggaccct	10	8	14	9	0	1	2	1	1	0	1	2	5	2	5	2	4	1	2	2	4	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:56332340G>C	uc001sij.2	+	6	659	c.395G>C	c.(394-396)AGC>ACC	p.S132T	DGKA_uc009zoc.1_Missense_Mutation_p.S132T|DGKA_uc001sih.1_Intron|DGKA_uc001sii.1_5'UTR|DGKA_uc009zod.1_Missense_Mutation_p.S51T|DGKA_uc009zoe.1_Missense_Mutation_p.S132T|DGKA_uc001sik.2_Missense_Mutation_p.S132T|DGKA_uc001sil.2_Missense_Mutation_p.S132T|DGKA_uc001sim.2_Missense_Mutation_p.S132T|DGKA_uc001sin.2_Missense_Mutation_p.S132T|DGKA_uc009zof.2_5'UTR|DGKA_uc001sio.2_5'UTR	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	132	1 (Probable).|EF-hand 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	ATCCTGGACAGCTCAGTGAGT	0.507													29	122					0	0	0	0	C	56332340	C	C	56332340	3	2	142	1	0	0	0	0	1	0	0	0	4487	971	34	4	413	4	DGKA	12	56332340	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	6836390	56332340	77519555	215	26102											
OS9	10956	broad.mit.edu	37	chr12	58090152	58090152	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaggccccgggaggccgaggTtcgggtgagtcttgagagag	7	6	20	8	3	1	3	0	2	1	1	2	7	1	4	3	5	0	1	3	5	0	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:58090152T>G	uc001spj.2	+	5	634	c.575T>G	c.(574-576)GTT>GGT	p.V192G	OS9_uc010srx.1_Intron|OS9_uc001spk.2_Missense_Mutation_p.V192G|OS9_uc001spl.2_Missense_Mutation_p.V192G|OS9_uc001spm.2_Missense_Mutation_p.V192G|OS9_uc001spn.2_Missense_Mutation_p.V192G|OS9_uc010sry.1_Intron|OS9_uc010srz.1_Missense_Mutation_p.V133G	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	192					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GAGGCCGAGGTTCGGGTGAGT	0.592													12	52					0	0	0	0	G	58090152	G	G	58090152	3	3	142	1	0	0	0	0	1	0	0	0	11326	1725	60	5	593	5	OS9	12	58090152	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	1757812	58090152	75761743	216	26103											
EEA1	8411	broad.mit.edu	37	chr12	93196189	93196189	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaactactaaccaagtctaaTatagcggcttttcctttctg	12	14	5	10	1	2	0	0	0	2	0	3	0	3	0	2	1	4	1	2	1	7	8			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:93196189T>C	uc001tck.2	-	19	2926	c.2661A>G	c.(2659-2661)ATA>ATG	p.I887M		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	887	Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						CCAAGTCTAATATAGCGGCTT	0.289													4	37					0	0	0	0	C	93196189	C	C	93196189	3	2	142	1	0	0	0	0	1	0	0	0	4943	1396	49	5	1618	5	EEA1	12	93196189	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	35106037	93196189	40655706	217	26104											
EEA1	8411	broad.mit.edu	37	chr12	93219970	93219970	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcgaagttttgccgtggtgCtttgctgaagagcctgttgt	5	15	13	8	2	0	2	0	1	0	1	1	3	0	2	2	1	4	4	2	1	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:93219970C>A	uc001tck.2	-	13	1761	c.1496G>T	c.(1495-1497)AGC>ATC	p.S499I		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	499	Gln/Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TGCCGTGGTGCTTTGCTGAAG	0.328													5	27					0.00116845	0.00221148	1	0	A	93219970	A	A	93219970	3	1	142	1	0	0	0	0	1	0	0	0	4943	797	28	4	2807	4	EEA1	12	93219970	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	23781	93219970	40631925	218	26105											
NR1H4	9971	broad.mit.edu	37	chr12	100955661	100955661	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgattgcaactttcccccacAggtatctctgatgaatatat	11	14	6	10	0	1	3	0	3	1	0	3	3	2	3	2	1	2	2	2	1	5	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:100955661A>T	uc001tht.1	+	8	1137	c.1109_splice	c.e8-2	p.G370_splice	NR1H4_uc001thp.1_Splice_Site_p.G356_splice|NR1H4_uc001thq.1_Splice_Site_p.G360_splice|NR1H4_uc010svj.1_Splice_Site|NR1H4_uc001thr.1_Splice_Site_p.G360_splice|NR1H4_uc010svk.1_Splice_Site_p.G309_splice|NR1H4_uc001ths.1_Splice_Site_p.G366_splice	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4						bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TTTCCCCCACAGGTATCTCTG	0.318													11	17					0	0	0	0	T	100955661	T	T	100955661	5	4	142	1	0	0	0	0	0	0	1	0	10673	202	7	5	1095	5	NR1H4	12	100955661	Splice_Site	SNP	A	TCGA-CR-7371-01A-11D-2012-08	7735691	100955661	32896234	219	26106											
WSCD2	9671	broad.mit.edu	37	chr12	108589738	108589738	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggctttgtgggccagccCgctgtctcggggaaccaggc	4	9	15	13	2	2	0	0	0	2	0	3	1	2	1	3	5	2	2	3	5	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:108589738C>T	uc001tms.2	+	2	873	c.129C>T	c.(127-129)CCC>CCT	p.P43P	WSCD2_uc001tmt.2_Silent_p.P43P	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	43						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						TGGGCCAGCCCGCTGTCTCGG	0.612													30	135					0	0	0	0	T	108589738	T	T	108589738	2	4	142	1	0	0	0	0	0	0	0	1	17475	639	23	1		1	WSCD2	12	108589738	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	7634077	108589738	25262157	220	26107											
C12orf34	84915	broad.mit.edu	37	chr12	110205834	110205834	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcgaggcggtggccagcGccatgcattcctcccgctac	6	6	13	16	4	0	0	0	0	0	0	2	1	2	0	4	4	3	2	4	4	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:110205834G>T	uc001tpd.1	+	3	659	c.100G>T	c.(100-102)GCC>TCC	p.A34S	MGC14436_uc010sxs.1_Intron|MGC14436_uc001tpe.2_Intron|C12orf34_uc001tpf.1_Missense_Mutation_p.A34S	NM_032829	NP_116218	Q5U5X8	CL034_HUMAN	hypothetical protein LOC84915	34										ovary(1)	1						GGTGGCCAGCGCCATGCATTC	0.652													7	52					0.00307968	0.00569465	1	0	T	110205834	T	T	110205834	3	4	142	1	0	0	0	0	1	0	0	0	1687	1087	38	3	106	3	C12orf34	12	110205834	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1616096	110205834	23646061	221	26108											
ATP2A2	488	broad.mit.edu	37	chr12	110784230	110784230	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ataatgcccctggtgatctgGgtctatagcacagacactaa	12	10	9	10	0	2	2	0	1	2	1	2	2	2	2	2	2	2	1	2	2	4	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:110784230G>T	uc001tqk.3	+	20	3647	c.3084G>T	c.(3082-3084)TGG>TGT	p.W1028C	ATP2A2_uc001tql.3_Intron|ATP2A2_uc010sxy.1_Missense_Mutation_p.W1001C|ATP2A2_uc001tqn.3_Missense_Mutation_p.W105C|ATP2A2_uc009zvn.2_Intron	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	1028	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						TGGTGATCTGGGTCTATAGCA	0.433													6	31					0.00198382	0.00369665	1	0	T	110784230	T	T	110784230	3	4	142	1	0	0	0	0	1	0	0	0	1139	1241	43	4	3162	4	ATP2A2	12	110784230	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	578396	110784230	23067665	222	26109											
RILPL1	353116	broad.mit.edu	37	chr12	124008157	124008157	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggagaggaggtcctgcgcCtcccctcgccacacatcctc	6	7	11	17	2	0	1	0	0	0	1	5	3	3	2	6	3	1	0	6	3	0	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:124008157C>T	uc001ufe.2	-	2	581	c.345G>A	c.(343-345)GAG>GAA	p.E115E	RILPL1_uc010tas.1_Silent_p.E115E	NM_178314	NP_847884	Q5EBL4	RIPL1_HUMAN	Rab interacting lysosomal protein-like 1	115	Potential.				neuroprotection	cytosol					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		GGTCCTGCGCCTCCCCTCGCC	0.627													10	31					0	0	0	0	T	124008157	T	T	124008157	2	4	142	1	0	0	0	0	0	0	0	1	13426	680	24	4		4	RILPL1	12	124008157	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	13223927	124008157	9843738	223	26110											
SFRS8	6433	broad.mit.edu	37	chr12	132281832	132281832	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcgccccggcccgcggccCccgcggcccactcggcgcac	3	1	13	24	8	0	0	0	0	0	0	1	0	0	0	6	4	1	1	6	4	0	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr12:132281832C>G	uc001uja.1	+	16	2784	c.2644C>G	c.(2644-2646)CCC>GCC	p.P882A	SFRS8_uc010tbn.1_Missense_Mutation_p.P934A	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	882	Arg/Ser-rich (RS domain).				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		gcccgcggcccccgcggcccA	0.557													15	60					0	0	0	0	G	132281832	G	G	132281832	3	3	142	1	0	0	0	0	1	0	0	0	14248	623	22	4	2706	4	SFRS8	12	132281832	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	8273675	132281832	1570063	224	26111											
TUBA3C	7278	broad.mit.edu	37	chr13	19748110	19748110	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgggcctcagagaactcccCctcctccatgccttctccca	6	8	7	20	1	2	1	1	0	1	1	6	2	5	1	7	1	2	0	7	1	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:19748110C>A	uc009zzj.2	-	5	1295	c.1246G>T	c.(1246-1248)GGG>TGG	p.G416W		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	416					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GAGAACTCCCCCTCCTCCATG	0.602													31	113					3.86903e-22	9.02357e-22	1	0	A	19748110	A	A	19748110	3	1	142	1	0	0	0	0	1	0	0	0	16814	623	22	4	110	4	TUBA3C	13	19748110	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08		19748110	95421768	225	26112											
ATP8A2	51761	broad.mit.edu	37	chr13	26154054	26154054	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgaaggacagagctcaacGgttggaagagtgttacgaga	14	8	14	5	2	1	4	1	1	0	3	1	7	1	6	0	3	3	3	0	3	4	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:26154054G>T	uc001uqk.2	+	22	2118	c.1976G>T	c.(1975-1977)CGG>CTG	p.R659L	ATP8A2_uc010tdi.1_Missense_Mutation_p.R619L|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.R169L	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	619	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGAGCTCAACGGTTGGAAGAG	0.438													13	28					2.61681e-11	5.66454e-11	1	0	T	26154054	T	T	26154054	3	4	142	1	0	0	0	0	1	0	0	0	1195	1116	39	3	2062	3	ATP8A2	13	26154054	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	6405944	26154054	89015824	226	26113											
FLT3	2322	broad.mit.edu	37	chr13	28589793	28589793	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actcttaatggtgtagatgcCttcaaacaggctttcggggg	9	12	12	8	1	2	1	1	0	1	1	3	1	2	1	1	4	2	2	1	4	3	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:28589793C>A	uc001urw.2	-	21	2669	c.2587G>T	c.(2587-2589)GGC>TGC	p.G863C	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.G822C	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	863	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GTGTAGATGCCTTCAAACAGG	0.483			Mis|O		AML|ALL								18	50					1.01871e-10	2.17265e-10	1	0	A	28589793	A	A	28589793	3	1	142	1	0	0	0	0	1	0	0	0	5974	681	24	4	410	4	FLT3	13	28589793	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	2435739	28589793	86580085	227	26114											
FREM2	341640	broad.mit.edu	37	chr13	39425083	39425083	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgacattattgttccaggtGagacagaaaagccctgcatt	12	11	9	9	0	0	3	0	2	0	2	1	4	1	3	2	1	2	2	2	1	3	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:39425083G>C	uc001uwv.2	+	10	6889	c.6580G>C	c.(6580-6582)GAG>CAG	p.E2194Q	FREM2_uc001uww.2_Missense_Mutation_p.E280Q	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2194	Extracellular (Potential).|Calx-beta 4.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGTTCCAGGTGAGACAGAAAA	0.378													11	49					0	0	0	0	C	39425083	C	C	39425083	3	2	142	1	0	0	0	0	1	0	0	0	6079	1291	45	2	6618	2	FREM2	13	39425083	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	10835290	39425083	75744795	228	26115											
LHFP	10186	broad.mit.edu	37	chr13	39952599	39952599	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagaagtgtagccacaagtCtgccggacttcctcactgtc	9	9	9	14	1	2	1	1	0	1	1	4	2	3	2	4	1	2	1	4	1	3	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:39952599C>G	uc001uxf.2	-	3	961	c.450G>C	c.(448-450)CAG>CAC	p.Q150H		NM_005780	NP_005771	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner precursor	150						integral to membrane	DNA binding		HMGA2/LHFP(2)	soft_tissue(2)|lung(1)|breast(1)	4		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		AGCCACAAGTCTGCCGGACTT	0.493			T	HMGA2	lipoma								16	51					0	0	0	0	G	39952599	G	G	39952599	3	3	142	1	0	0	0	0	1	0	0	0	8804	912	32	2	160	2	LHFP	13	39952599	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	527516	39952599	75217279	229	26116											
NALCN	259232	broad.mit.edu	37	chr13	101747987	101747987	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaattttaaatttaagttCtttgacacactgacattaat	14	17	3	7	0	2	2	1	2	1	0	2	2	2	2	0	0	0	1	0	0	5	7			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr13:101747987C>G	uc001vox.1	-	28	3396	c.3207G>C	c.(3205-3207)AAG>AAC	p.K1069N		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1069	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AATTTAAGTTCTTTGACACAC	0.358													9	47					0	0	0	0	G	101747987	G	G	101747987	3	3	142	1	0	0	0	0	1	0	0	0	10201	912	32	2	2077	2	NALCN	13	101747987	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	61795388	101747987	13421891	230	26117											
TEP1	7011	broad.mit.edu	37	chr14	20849805	20849805	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcccatcagggaggcacaGccgggcaccagggcgctcca	8	2	16	15	2	1	0	1	0	0	0	2	1	2	1	4	5	1	3	4	5	0	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:20849805G>A	uc001vxe.2	-	31	4505	c.4465C>T	c.(4465-4467)CTG>TTG	p.L1489L	TEP1_uc010ahk.2_Silent_p.L832L|TEP1_uc010tlf.1_Intron|TEP1_uc010tlg.1_Silent_p.L1381L|TEP1_uc010tlh.1_Intron	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1489	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGGAGGCACAGCCGGGCACCA	0.602													17	92					0	0	0	0	A	20849805	A	A	20849805	2	1	142	1	0	0	0	0	0	0	0	1	15825	962	34	4		4	TEP1	14	20849805	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08		20849805	86499735	231	26118											
OR4E2	26686	broad.mit.edu	37	chr14	22133982	22133982	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtttctcttcgaaaacactCagctgaagggcgccagaaag	12	8	11	10	2	2	2	1	1	1	1	4	3	2	2	1	2	2	2	1	2	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:22133982C>G	uc010tmd.1	+	1	686	c.686C>G	c.(685-687)TCA>TGA	p.S229*		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CGAAAACACTCAGCTGAAGGG	0.517													11	64					0	0	0	0	G	22133982	G	G	22133982	4	3	142	1	0	0	0	0	0	1	0	0	11114	838	29	2	688	2	OR4E2	14	22133982	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1284177	22133982	85215558	232	26119											
PRKD1	5587	broad.mit.edu	37	chr14	30066700	30066700	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaatggaagatattaccttCatgagatatttccttccagg	12	14	8	7	0	1	3	1	2	0	2	3	5	3	4	3	2	1	0	3	2	5	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:30066700C>G	uc001wqh.2	-	16	2612	c.2431G>C	c.(2431-2433)GAA>CAA	p.E811Q		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	811	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		ATATTACCTTCATGAGATATT	0.274													12	66					0	0	0	0	G	30066700	G	G	30066700	3	3	142	1	0	0	0	0	1	0	0	0	12580	835	29	2	319	2	PRKD1	14	30066700	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	7932718	30066700	77282840	233	26120											
NPAS3	64067	broad.mit.edu	37	chr14	33684490	33684490	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaagttgttgcctcttccTgcagccattaccagccagct	7	11	8	15	0	1	0	0	0	1	0	2	0	2	0	6	0	6	4	6	0	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:33684490T>A	uc001wru.2	+	3	307	c.243T>A	c.(241-243)CCT>CCA	p.P81P	NPAS3_uc001wrs.2_Silent_p.P51P|NPAS3_uc001wrt.2_Silent_p.P51P|NPAS3_uc001wrv.2_Silent_p.P51P|NPAS3_uc001wrw.2_5'UTR	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	81	Helix-loop-helix motif.			PLP -> LS (in Ref. 4; CAB45154).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		TGCCTCTTCCTGCAGCCATTA	0.493													17	103					0	0	0	0	A	33684490	A	A	33684490	2	1	142	1	0	0	0	0	0	0	0	1	10618	1567	55	5		5	NPAS3	14	33684490	Silent	SNP	T	TCGA-CR-7371-01A-11D-2012-08	3617790	33684490	73665050	234	26121											
MIPOL1	145282	broad.mit.edu	37	chr14	37754564	37754564	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcgcagaaggaacgtgatGaagctgttatgtctagactg	11	11	13	6	2	1	4	0	2	1	2	1	5	1	5	0	1	3	3	0	1	5	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:37754564G>T	uc001wuc.2	+	8	1038	c.535G>T	c.(535-537)GAA>TAA	p.E179*	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Nonsense_Mutation_p.E148*|MIPOL1_uc001wud.2_Nonsense_Mutation_p.E179*|MIPOL1_uc010ams.2_Nonsense_Mutation_p.E179*|MIPOL1_uc001wue.2_Nonsense_Mutation_p.E148*|MIPOL1_uc010amt.2_5'UTR	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	179	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		GGAACGTGATGAAGCTGTTAT	0.378													14	79					1.02788e-11	2.252e-11	1	0	T	37754564	T	T	37754564	4	4	142	1	0	0	0	0	0	1	0	0	9646	1291	45	2	553	2	MIPOL1	14	37754564	Nonsense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	4070074	37754564	69594976	235	26122											
SSTR1	6751	broad.mit.edu	37	chr14	38679129	38679130	+	Frame_Shift_Ins	INS	-	T	T																															cgtggccaaggtagtaaaccINStgggcgtgtgggtgctatcg																										TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:38679129_38679130insT	uc001wul.1	+	3	1152_1153	c.535_536insT	c.(535-537)CTGfs	p.L179fs	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	179	Helical; Name=4; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GGTAGTAAACCTGGGCGTGTGG	0.644													---	---	---								T	38679130	T	T	38679129	7	5	142	1	0	1	1	0	0	0	0	0	15263	680	24	0	537	0	SSTR1	14	38679129	Frame_Shift_Ins	INS	-	TCGA-CR-7371-01A-11D-2012-08	924565	38679129	68670411	236	26123											
SSTR1	6751	broad.mit.edu	37	chr14	38679680	38679680	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accgcgctcaagagccgtgcCtacagtgtggaagacttcca	10	7	11	13	3	1	2	1	0	0	2	2	3	2	3	4	1	3	1	4	1	3	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:38679680C>A	uc001wul.1	+	3	1703	c.1086C>A	c.(1084-1086)GCC>GCA	p.A362A	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	362	Cytoplasmic (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	AGAGCCGTGCCTACAGTGTGG	0.612													18	75					3.51602e-12	7.77394e-12	1	0	A	38679680	A	A	38679680	2	1	142	1	0	0	0	0	0	0	0	1	15263	668	24	4		4	SSTR1	14	38679680	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	551	38679680	68669860	237	26124											
LRFN5	145581	broad.mit.edu	37	chr14	42356976	42356976	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctccctcacttactaaataGtacaaaccatatccatgagc	14	10	4	13	0	1	1	1	1	0	0	3	1	3	1	3	0	4	2	3	0	7	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:42356976G>T	uc001wvm.2	+	3	2346	c.1148G>T	c.(1147-1149)AGT>ATT	p.S383I	LRFN5_uc010ana.2_Missense_Mutation_p.S383I	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	383	Extracellular (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TTACTAAATAGTACAAACCAT	0.393										HNSCC(30;0.082)			10	56					1.58986e-06	3.19298e-06	1	0	T	42356976	T	T	42356976	3	4	142	1	0	0	0	0	1	0	0	0	8991	1029	36	4	1150	4	LRFN5	14	42356976	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	3677296	42356976	64992564	238	26125											
FSCB	84075	broad.mit.edu	37	chr14	44975712	44975712	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaccactatttctgattcaCtaaagtatgtctgttgttcc	10	17	5	9	0	3	1	1	1	2	0	4	1	4	1	2	0	1	3	2	0	5	8			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:44975712C>A	uc001wvn.2	-	1	788	c.479G>T	c.(478-480)AGT>ATT	p.S160I		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	160						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TTCTGATTCACTAAAGTATGT	0.418													29	157					1.13719e-10	2.4182e-10	1	0	A	44975712	A	A	44975712	3	1	142	1	0	0	0	0	1	0	0	0	6100	565	20	4	2002	4	FSCB	14	44975712	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	2618736	44975712	62373828	239	26126											
FSCB	84075	broad.mit.edu	37	chr14	44975773	44975773	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggatgttcatcatggtccAgtatcctgtacggctggtct	6	13	13	9	1	3	0	2	0	1	0	5	1	5	1	2	5	1	4	2	5	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:44975773A>T	uc001wvn.2	-	1	727	c.418T>A	c.(418-420)TGG>AGG	p.W140R		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	140						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		ATCATGGTCCAGTATCCTGTA	0.423													39	164					0	0	0	0	T	44975773	T	T	44975773	3	4	142	1	0	0	0	0	1	0	0	0	6100	188	7	5	2063	5	FSCB	14	44975773	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	61	44975773	62373767	240	26127											
FKBP3	2287	broad.mit.edu	37	chr14	45590112	45590112	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctctgataactttgcctactCcgaccttaaaacttaaaggc	12	12	5	12	1	1	1	0	1	1	0	2	2	2	1	3	1	4	0	3	1	6	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:45590112C>G	uc010tqf.1	-	5	573	c.500G>C	c.(499-501)GGA>GCA	p.G167A		NM_002013	NP_002004	Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	167	PPIase FKBP-type.				protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity				0						TTTGCCTACTCCGACCTTAAA	0.333													3	61					0	0	0	0	G	45590112	G	G	45590112	3	3	142	1	0	0	0	0	1	0	0	0	5941	855	30	2	186	2	FKBP3	14	45590112	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	614339	45590112	61759428	241	26128											
FRMD6	122786	broad.mit.edu	37	chr14	52194577	52194577	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctgtgtcaggacactgctCagagttacacctttggatgt	8	13	11	9	0	3	1	2	0	1	1	3	3	3	3	1	2	2	2	1	2	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:52194577C>G	uc001wzd.2	+	14	1984	c.1699C>G	c.(1699-1701)CAG>GAG	p.Q567E	FRMD6_uc001wzb.2_Missense_Mutation_p.Q559E|FRMD6_uc001wzc.2_Missense_Mutation_p.Q559E|FRMD6_uc001wze.2_Missense_Mutation_p.Q490E|FRMD6_uc001wzf.2_Missense_Mutation_p.Q260E|FRMD6_uc001wzg.2_Missense_Mutation_p.Q209E	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	567						cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					GGACACTGCTCAGAGTTACAC	0.502													11	45					0	0	0	0	G	52194577	G	G	52194577	3	3	142	1	0	0	0	0	1	0	0	0	6088	827	29	2	1725	2	FRMD6	14	52194577	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	6604465	52194577	55154963	242	26129											
ABCD4	5826	broad.mit.edu	37	chr14	74761852	74761852	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatctctccagactcaccTgtagaaagcagcaggctccg	11	7	8	15	1	2	2	1	0	1	2	5	2	4	2	4	1	2	4	4	1	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:74761852T>A	uc001xpr.2	-	7	870	c.718A>T	c.(718-720)AGA>TGA	p.R240*	ABCD4_uc001xps.2_Nonsense_Mutation_p.R81*|ABCD4_uc001xpt.2_Nonsense_Mutation_p.R81*|ABCD4_uc010tur.1_Intron|ABCD4_uc001xpu.2_Silent_p.T8T|ABCD4_uc001xpv.2_RNA	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	240	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		CAGACTCACCTGTAGAAAGCA	0.562													17	54					0	0	0	0	A	74761852	A	A	74761852	4	1	142	1	0	0	0	0	0	1	0	0	63	1594	55	5	1154	5	ABCD4	14	74761852	Nonsense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	22567275	74761852	32587688	243	26130											
TMEM90A	646658	broad.mit.edu	37	chr14	74874270	74874270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gttctgggacatgtaagctgCcagagccaccaccacagcca	11	6	10	14	0	1	1	0	0	1	1	1	2	1	2	5	1	4	3	5	1	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:74874270C>T	uc001xpx.2	-	4	933	c.685G>A	c.(685-687)GCA>ACA	p.A229T		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	229					response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		ATGTAAGCTGCCAGAGCCACC	0.652													17	68					0	0	0	0	T	74874270	T	T	74874270	3	4	142	1	0	0	0	0	1	0	0	0	16284	739	26	4	35	4	TMEM90A	14	74874270	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	112418	74874270	32475270	244	26131											
KCNK10	54207	broad.mit.edu	37	chr14	88707107	88707107	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgaggtcccagtggctgcTgttgttggaagagtttccta	6	12	14	9	1	0	1	0	0	0	1	2	3	2	2	3	3	1	5	3	3	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:88707107T>A	uc001xwo.2	-	3	902	c.445A>T	c.(445-447)AGC>TGC	p.S149C	KCNK10_uc001xwm.2_Missense_Mutation_p.S154C|KCNK10_uc001xwn.2_Missense_Mutation_p.S154C	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	149					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						CAGTGGCTGCTGTTGTTGGAA	0.458													27	105					0	0	0	0	A	88707107	A	A	88707107	3	1	142	1	0	0	0	0	1	0	0	0	8098	1580	55	5	1191	5	KCNK10	14	88707107	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	13832837	88707107	18642433	245	26132											
SPATA7	55812	broad.mit.edu	37	chr14	88904701	88904701	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaaggcgacaataatcatGacatggagttatcaactctt	15	11	7	8	1	4	1	3	1	1	0	4	3	4	2	0	2	1	1	0	2	5	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:88904701G>C	uc001xwq.2	+	12	1886	c.1735G>C	c.(1735-1737)GAC>CAC	p.D579H	SPATA7_uc001xwr.2_Missense_Mutation_p.D547H|SPATA7_uc001xws.2_Missense_Mutation_p.D515H|SPATA7_uc001xwt.2_Missense_Mutation_p.D473H|SPATA7_uc001xwu.2_Missense_Mutation_p.D94H	NM_018418	NP_060888	Q9P0W8	SPAT7_HUMAN	spermatogenesis-associated protein 7 isoform a	579					response to stimulus|visual perception					ovary(1)	1						CAATAATCATGACATGGAGTT	0.383													7	28					0	0	0	0	C	88904701	C	C	88904701	3	2	142	1	0	0	0	0	1	0	0	0	15080	1290	45	2	1781	2	SPATA7	14	88904701	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	197594	88904701	18444839	246	26133											
TTC8	123016	broad.mit.edu	37	chr14	89305909	89305909	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatgaaaatgctatagctcaAgttccacgtaagtattgggt	13	12	10	6	1	1	1	1	1	0	0	2	2	2	1	1	1	2	5	1	1	7	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:89305909A>G	uc010ath.2	+	2	362	c.228A>G	c.(226-228)CAA>CAG	p.Q76Q	TTC8_uc010atg.1_RNA|TTC8_uc001xxl.2_5'UTR|TTC8_uc010ati.2_5'UTR|TTC8_uc001xxm.2_Silent_p.Q76Q|TTC8_uc010atj.2_Intron|TTC8_uc001xxi.2_Silent_p.Q86Q|TTC8_uc001xxj.2_Silent_p.Q76Q|TTC8_uc001xxk.2_Silent_p.Q76Q	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	86					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						CTATAGCTCAAGTTCCACGTA	0.328									Bardet-Biedl_syndrome				6	45					0	0	0	0	G	89305909	G	G	89305909	2	3	142	1	0	0	0	0	0	0	0	1	16782	69	3	5		5	TTC8	14	89305909	Silent	SNP	A	TCGA-CR-7371-01A-11D-2012-08	401208	89305909	18043631	247	26134											
CCDC88C	440193	broad.mit.edu	37	chr14	91780146	91780146	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagagtccggttctccagctGcaggccctggctctcatgct	5	10	11	15	1	2	1	1	0	2	1	5	1	3	1	3	3	3	5	3	3	0	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:91780146G>A	uc010aty.2	-	15	2113	c.2014C>T	c.(2014-2016)CAG>TAG	p.Q672*		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	672	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				TTCTCCAGCTGCAGGCCCTGG	0.627													6	15					0	0	0	0	A	91780146	A	A	91780146	4	1	142	1	0	0	0	0	0	1	0	0	2878	1328	46	4	4136	4	CCDC88C	14	91780146	Nonsense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	2474237	91780146	15569394	248	26135											
PAPOLA	10914	broad.mit.edu	37	chr14	97022574	97022574	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccatttctccaccaccaaagCctacggtctccagagttgtt	9	11	6	15	1	2	1	0	0	2	1	4	1	2	1	6	1	2	2	6	1	2	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:97022574C>T	uc001yfq.2	+	19	2038	c.1828C>T	c.(1828-1830)CCT>TCT	p.P610S	PAPOLA_uc001yfr.2_Missense_Mutation_p.P609S|PAPOLA_uc010twv.1_Missense_Mutation_p.P610S|PAPOLA_uc010avp.2_Missense_Mutation_p.P360S	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	610	Ser/Thr-rich.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		ACCACCAAAGCCTACGGTCTC	0.418													22	86					0	0	0	0	T	97022574	T	T	97022574	3	4	142	1	0	0	0	0	1	0	0	0	11483	739	26	4	1902	4	PAPOLA	14	97022574	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	5242428	97022574	10326966	249	26136											
DIO3	1735	broad.mit.edu	37	chr14	102028010	102028010	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcggcacggccttcatgctCtggcttctcgatttcttgtg	3	15	10	13	3	4	0	1	0	3	0	6	1	4	0	1	3	1	3	1	3	0	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr14:102028010C>G	uc010txq.1	+	1	323	c.99C>G	c.(97-99)CTC>CTG	p.L33L	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	33	Helical; Signal-anchor for type II membrane protein; (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				CCTTCATGCTCTGGCTTCTCG	0.657													10	77					0	0	0	0	G	102028010	G	G	102028010	2	3	142	1	0	0	0	0	0	0	0	1	4548	900	32	2		2	DIO3	14	102028010	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	5005436	102028010	5321530	250	26137											
MAGEL2	54551	broad.mit.edu	37	chr15	23890179	23890179	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggccctgccagtcatgaaagGctagcgtgtggccacggctg	7	7	15	12	2	1	1	1	1	0	0	1	1	1	1	3	4	2	2	3	4	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:23890179G>A	uc001ywj.3	-	1	997	c.902C>T	c.(901-903)GCC>GTC	p.A301V		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GTCATGAAAGGCTAGCGTGTG	0.627													18	46					0	0	0	0	A	23890179	A	A	23890179	3	1	142	1	0	0	0	0	1	0	0	0	9242	1203	42	4	1042	4	MAGEL2	15	23890179	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08		23890179	78641213	251	26138											
TTBK2	146057	broad.mit.edu	37	chr15	43067454	43067454	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgttctgaagcagcagtaGgaggaccctctgcagaaagt	12	9	12	8	0	2	2	0	1	2	1	2	4	2	4	1	2	3	5	1	2	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:43067454G>A	uc001zqo.2	-	13	2316	c.1877C>T	c.(1876-1878)CCT>CTT	p.P626L	TTBK2_uc010bcy.2_Missense_Mutation_p.P557L	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	626					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		AGCAGCAGTAGGAGGACCCTC	0.488													63	67					0	0	0	0	A	43067454	A	A	43067454	3	1	142	1	0	0	0	0	1	0	0	0	16745	1000	35	4	1869	4	TTBK2	15	43067454	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	19177275	43067454	59463938	252	26139											
USP8	9101	broad.mit.edu	37	chr15	50786338	50786338	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catgaaagccctgtggacagGacagtatagatatatcagtc	14	9	10	8	0	1	2	1	1	0	1	2	4	1	4	1	2	1	1	1	2	5	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:50786338G>A	uc001zym.3	+	17	3019	c.2519G>A	c.(2518-2520)GGA>GAA	p.G840E	USP8_uc001zyl.3_Missense_Mutation_p.G840E|USP8_uc001zyn.3_Missense_Mutation_p.G840E|USP8_uc010ufh.1_Missense_Mutation_p.G734E|uc001zyo.1_RNA|USP8_uc001zyp.3_Missense_Mutation_p.G7E	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	840					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CTGTGGACAGGACAGTATAGA	0.383													19	87					0	0	0	0	A	50786338	A	A	50786338	3	1	142	1	0	0	0	0	1	0	0	0	17157	1174	41	2	2577	2	USP8	15	50786338	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	7718884	50786338	51745054	253	26140											
NOX5	79400	broad.mit.edu	37	chr15	69335123	69335123	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcgaggagtgtgacaatgaGaaagagtcaaaggtcgtcca	14	7	14	6	2	1	3	1	2	0	2	4	6	2	4	1	2	0	0	1	2	3	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:69335123G>C	uc002ars.1	+	10	1645	c.1625G>C	c.(1624-1626)AGA>ACA	p.R542T	NOX5_uc002arp.1_Missense_Mutation_p.R524T|NOX5_uc002arq.1_Missense_Mutation_p.R496T|NOX5_uc010bid.1_Missense_Mutation_p.R507T|NOX5_uc002arr.1_Missense_Mutation_p.R514T|NOX5_uc010bie.1_Missense_Mutation_p.R342T|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	542	FAD-binding FR-type.|Cytoplasmic (Potential).|C-terminal catalytic region.				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						GTGACAATGAGAAAGAGTCAA	0.552													19	17					0	0	0	0	C	69335123	C	C	69335123	3	2	142	1	0	0	0	0	1	0	0	0	10613	942	33	2	1696	2	NOX5	15	69335123	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	18548785	69335123	33196269	254	26141											
LINGO1	84894	broad.mit.edu	37	chr15	77906424	77906424	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacttgcggggcgcgtcggCggagctgatgcctgcgtccg	4	7	18	12	7	0	1	0	1	0	0	2	3	1	2	2	4	5	1	2	4	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:77906424C>A	uc002bct.1	-	2	1877	c.1825G>T	c.(1825-1827)GCC>TCC	p.A609S	LINGO1_uc002bcu.1_Missense_Mutation_p.A603S	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	609	Cytoplasmic (Potential).				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						GGCGCGTCGGCGGAGCTGATG	0.493													10	15					2.17888e-05	4.28078e-05	1	0	A	77906424	A	A	77906424	3	1	142	1	0	0	0	0	1	0	0	0	8856	768	27	3	41	3	LINGO1	15	77906424	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	8571301	77906424	24624968	255	26142											
ADAMTS17	170691	broad.mit.edu	37	chr15	100672232	100672232	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggggttgtcacatttcctCtgcctgaagcgggctcccgt	4	11	14	12	2	2	1	1	1	1	0	4	1	4	1	3	4	2	2	3	4	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr15:100672232C>G	uc002bvv.1	-	12	1780	c.1701G>C	c.(1699-1701)CAG>CAC	p.Q567H	ADAMTS17_uc002bvx.1_Missense_Mutation_p.Q324H	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	567	TSP type-1 1.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CACATTTCCTCTGCCTGAAGC	0.627											OREG0023513	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	79					0	0	0	0	G	100672232	G	G	100672232	3	3	142	1	0	0	0	0	1	0	0	0	262	912	32	2	1630	2	ADAMTS17	15	100672232	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	22765808	100672232	1859160	256	26143											
RPL3L	6123	broad.mit.edu	37	chr16	1996719	1996719	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgcgggcccctgccgatGcggaagatctgccagaaggg	8	6	16	11	3	1	2	0	0	1	2	1	4	1	3	4	3	4	0	4	3	2	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:1996719G>C	uc002cnh.2	-	7	905	c.858C>G	c.(856-858)CGC>CGG	p.R286R		NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	286					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						CCCTGCCGATGCGGAAGATCT	0.632													8	28					0	0	0	0	C	1996719	C	C	1996719	2	2	142	1	0	0	0	0	0	0	0	1	13659	1306	46	4		4	RPL3L	16	1996719	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08		1996719	88358034	257	26144											
CLEC16A	23274	broad.mit.edu	37	chr16	11071128	11071128	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctggtggcagagcacctaGaccacctgcactatctcaat	11	9	8	13	0	2	2	1	0	2	2	3	2	2	2	3	2	2	3	3	2	3	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:11071128G>C	uc002dao.2	+	8	1005	c.775G>C	c.(775-777)GAC>CAC	p.D259H	CLEC16A_uc002dan.3_Missense_Mutation_p.D257H	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	259										ovary(1)|central_nervous_system(1)	2						AGAGCACCTAGACCACCTGCA	0.537													11	69					0	0	0	0	C	11071128	C	C	11071128	3	2	142	1	0	0	0	0	1	0	0	0	3515	942	33	2	801	2	CLEC16A	16	11071128	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	9074409	11071128	79283625	258	26145											
ITGAL	3683	broad.mit.edu	37	chr16	30518132	30518132	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tactgggtccagctggacctGcacttccccccgggactctc	5	9	10	17	1	1	0	0	0	1	0	4	2	3	2	5	3	3	2	5	3	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:30518132G>C	uc002dyi.3	+	21	2639	c.2463G>C	c.(2461-2463)CTG>CTC	p.L821L	ITGAL_uc002dyj.3_Silent_p.L737L|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	821	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	AGCTGGACCTGCACTTCCCCC	0.602													33	180					0	0	0	0	C	30518132	C	C	30518132	2	2	142	1	0	0	0	0	0	0	0	1	7925	1306	46	4		4	ITGAL	16	30518132	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	19447004	30518132	59836621	259	26146											
ZNF668	79759	broad.mit.edu	37	chr16	31073227	31073227	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgccacgaacgtcttgtcaCattgcaggcacttgaacggc	10	8	10	13	4	2	1	1	1	1	0	2	2	2	1	1	2	3	2	1	2	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:31073227C>T	uc010caf.2	-	3	1379	c.1022G>A	c.(1021-1023)TGT>TAT	p.C341Y	ZNF668_uc002eao.2_Missense_Mutation_p.C341Y	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	341	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						CGTCTTGTCACATTGCAGGCA	0.677													13	59					0	0	0	0	T	31073227	T	T	31073227	3	4	142	1	0	0	0	0	1	0	0	0	18142	478	17	4	841	4	ZNF668	16	31073227	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	555095	31073227	59281526	260	26147											
C16orf58	64755	broad.mit.edu	37	chr16	31502206	31502206	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccatgtggccctccactcatCcacctctagctggtgcttct	5	12	7	17	0	3	0	1	0	2	0	5	0	5	0	5	2	2	2	5	2	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:31502206C>T	uc002eci.1	-	13	1369	c.1357G>A	c.(1357-1359)GGT>AGT	p.G453S	C16orf58_uc002ecg.2_5'Flank|C16orf58_uc002ech.1_Missense_Mutation_p.D191N	NM_022744	NP_073581	Q96GQ5	CP058_HUMAN	hypothetical protein LOC64755	453				D -> G (in Ref. 1; BAB14730).		integral to membrane				ovary(1)|breast(1)	2						CTCCACTCATCCACCTCTAGC	0.612													20	71					0	0	0	0	T	31502206	T	T	31502206	3	4	142	1	0	0	0	0	1	0	0	0	1828	855	30	2	53	2	C16orf58	16	31502206	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	428979	31502206	58852547	261	26148											
CSNK2A2	1459	broad.mit.edu	37	chr16	58198043	58198043	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggctgggactgctccttcaCcacagggtctgcaagaaagc	10	7	12	12	0	2	1	1	0	1	1	3	2	3	2	2	3	3	3	2	3	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:58198043C>A	uc002enc.2	-	11	1127	c.985G>T	c.(985-987)GTG>TTG	p.V329L		NM_001896	NP_001887	P19784	CSK22_HUMAN	casein kinase 2, alpha prime polypeptide	329					axon guidance|Wnt receptor signaling pathway	cytosol|nucleus	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						TGCTCCTTCACCACAGGGTCT	0.547													13	58					1.61879e-10	3.42218e-10	1	0	A	58198043	A	A	58198043	3	1	142	1	0	0	0	0	1	0	0	0	3975	507	18	4	71	4	CSNK2A2	16	58198043	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	26695837	58198043	32156710	262	26149											
CALB2	794	broad.mit.edu	37	chr16	71406097	71406097	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagctagaaaactttttcCaagagctggagaaggcaagg	16	7	12	6	0	0	4	0	0	0	4	1	5	1	4	1	3	3	3	1	3	7	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:71406097C>T	uc002faa.3	+	2	206	c.136C>T	c.(136-138)CAA>TAA	p.Q46*	CALB2_uc010vme.1_RNA|CALB2_uc002fac.3_Nonsense_Mutation_p.Q46*	NM_001740	NP_001731	P22676	CALB2_HUMAN	calbindin 2 isoform 1	46	EF-hand 1.						calcium ion binding				0		Ovarian(137;0.125)				AAACTTTTTCCAAGAGCTGGA	0.458													13	58					0	0	0	0	T	71406097	T	T	71406097	4	4	142	1	0	0	0	0	0	1	0	0	2586	595	21	4	142	4	CALB2	16	71406097	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	13208054	71406097	18948656	263	26150											
USP10	9100	broad.mit.edu	37	chr16	84808830	84808830	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaacctatcggctctttgcAggtgagtaaatttgtacgac	10	12	10	9	3	1	1	0	1	1	0	2	3	1	1	1	2	3	4	1	2	5	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr16:84808830A>T	uc002fii.2	+	13	2350	c.2208A>T	c.(2206-2208)GCA>GCT	p.A736A	USP10_uc010voe.1_Silent_p.A740A|USP10_uc010vof.1_Silent_p.A298A|USP10_uc002fij.2_Silent_p.A262A	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	736					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						GGCTCTTTGCAGGTGAGTAAA	0.403													19	58					0	0	0	0	T	84808830	T	T	84808830	2	4	142	1	0	0	0	0	0	0	0	1	17109	202	7	5		5	USP10	16	84808830	Silent	SNP	A	TCGA-CR-7371-01A-11D-2012-08	13402733	84808830	5545923	264	26151											
USP6	9098	broad.mit.edu	37	chr17	5036229	5036229	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcggcgggagatgacacgaAcgagcaagtggatggaaatg	13	6	16	6	4	0	2	0	1	0	1	1	7	0	4	0	4	2	1	0	4	3	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:5036229A>G	uc002gau.1	+	13	2450	c.220A>G	c.(220-222)ACG>GCG	p.T74A	USP6_uc002gav.1_Missense_Mutation_p.T74A|USP6_uc010ckz.1_5'UTR|USP6_uc002gaw.2_Missense_Mutation_p.T135A|uc002gay.1_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	74					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						GATGACACGAACGAGCAAGTG	0.532			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								3	153					0	0	0	0	G	5036229	G	G	5036229	3	3	142	1	0	0	0	0	1	0	0	0	17154	43	2	5	234	5	USP6	17	5036229	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08		5036229	76158981	265	26152											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	7	7	13	14	3	3	0	3	0	0	0	4	0	4	0	3	3	3	2	3	3	1	0	rs28934578		TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	36					0	0	0	0	T	7578406	T	T	7578406	3	4	142	1	0	0	0	0	1	0	0	0	16448	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	2542177	7578406	73616804	266	26153											
NTN1	9423	broad.mit.edu	37	chr17	9143248	9143248	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggcggctgcgcaagttccAgcagcgtgagaagaagggca	10	4	17	10	4	0	2	0	1	0	2	1	3	1	2	1	3	3	5	1	3	3	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:9143248A>G	uc002glw.3	+	7	1885	c.1778A>G	c.(1777-1779)CAG>CGG	p.Q593R		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	593	NTR.				apoptosis|axon guidance		protein binding				0						CGCAAGTTCCAGCAGCGTGAG	0.607													3	13					0	0	0	0	G	9143248	G	G	9143248	3	3	142	1	0	0	0	0	1	0	0	0	10754	188	7	5	1800	5	NTN1	17	9143248	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	1564842	9143248	72051962	267	26154											
MYH13	8735	broad.mit.edu	37	chr17	10213055	10213055	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgctcgatttcttcatcCttctcaatgaccttgcggtc	6	15	7	13	2	3	1	2	1	2	0	7	2	4	1	2	1	3	2	2	1	1	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:10213055C>A	uc002gmk.1	-	34	4839	c.4749G>T	c.(4747-4749)AAG>AAT	p.K1583N		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1583	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TTTCTTCATCCTTCTCAATGA	0.562													3	7					6.4e-05	0.000124722	1	0	A	10213055	A	A	10213055	3	1	142	1	0	0	0	0	1	0	0	0	10085	680	24	4	1099	4	MYH13	17	10213055	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1069807	10213055	70982155	268	26155											
NOS2	4843	broad.mit.edu	37	chr17	26107912	26107912	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagcggccgtacttgggcttCcagcccaggtcgatgcacag	8	7	13	13	3	0	0	0	0	0	0	2	1	1	0	3	3	4	3	3	3	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:26107912C>T	uc002gzu.2	-	9	1149	c.885G>A	c.(883-885)TGG>TGA	p.W295*	NOS2_uc010crh.1_Nonsense_Mutation_p.W295*|NOS2_uc010wab.1_Nonsense_Mutation_p.W295*	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	295					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	ACTTGGGCTTCCAGCCCAGGT	0.627													11	39					0	0	0	0	T	26107912	T	T	26107912	4	4	142	1	0	0	0	0	0	1	0	0	10597	856	30	2	2652	2	NOS2	17	26107912	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	15894857	26107912	55087298	269	26156											
C17orf63	55731	broad.mit.edu	37	chr17	27085655	27085655	+	Frame_Shift_Del	DEL	G	-	-																															gaccattggggtaggccaatGgggctgccatgccgttgact																										TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:27085655delG	uc002hct.1	-	3	1589	c.1322delC	c.(1321-1323)CCAfs	p.P441fs	C17orf63_uc010wax.1_Frame_Shift_Del_p.P441fs|C17orf63_uc010way.1_Frame_Shift_Del_p.P441fs|C17orf63_uc002hcw.2_Frame_Shift_Del_p.P313fs	NM_018182	NP_060652	Q8WU58	CQ063_HUMAN	hypothetical protein LOC55731	441										ovary(1)	1	all_epithelial(6;5.06e-20)|Lung NSC(42;0.01)		Epithelial(11;3.38e-06)|all cancers(11;2.46e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.104)			GTAGGCCAATGGGGCTGCCAT	0.612													---	---	---								-	27085655	-	-	27085655	7	5	142	1	0	1	0	1	0	0	0	0	1878	1348	47	0		0	C17orf63	17	27085655	Frame_Shift_Del	DEL	G	TCGA-CR-7371-01A-11D-2012-08	977743	27085655	54109555	270	26157											
LRRC46	90506	broad.mit.edu	37	chr17	45914142	45914142	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaaggagctggagcaggagCtgagcaggcacagggagcac	12	3	17	9	0	1	1	1	1	0	0	1	5	1	5	0	5	5	6	0	5	1	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:45914142C>A	uc002ima.2	+	8	878	c.622C>A	c.(622-624)CTG>ATG	p.L208M	LRRC46_uc002imb.2_Missense_Mutation_p.L161M	NM_033413	NP_219481	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	208	Potential.									ovary(1)	1						GGAGCAGGAGCTGAGCAGGCA	0.687													5	41					0.00116845	0.00221148	1	0	A	45914142	A	A	45914142	3	1	142	1	0	0	0	0	1	0	0	0	9053	796	28	4	652	4	LRRC46	17	45914142	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	18828487	45914142	35281068	271	26158											
NFE2L1	4779	broad.mit.edu	37	chr17	46135825	46135825	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcttactcttcagccccGaggtggaaagcctgcctgtg	7	11	10	13	1	3	0	1	0	2	0	3	2	3	1	4	2	4	0	4	2	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:46135825G>T	uc002imz.3	+	6	1792	c.1141G>T	c.(1141-1143)GAG>TAG	p.E381*	NFE2L1_uc002ina.3_Nonsense_Mutation_p.E351*|NFE2L1_uc002inb.3_Nonsense_Mutation_p.E351*|NFE2L1_uc010wle.1_Nonsense_Mutation_p.E193*|NFE2L1_uc010wlf.1_Nonsense_Mutation_p.E225*	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	381					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						CTTCAGCCCCGAGGTGGAAAG	0.607													32	85					9.78306e-22	2.27433e-21	1	0	T	46135825	T	T	46135825	4	4	142	1	0	0	0	0	0	1	0	0	10421	1059	37	3	1159	3	NFE2L1	17	46135825	Nonsense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	221683	46135825	35059385	272	26159											
TTLL6	284076	broad.mit.edu	37	chr17	46867429	46867429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	accatctttcacctctttatCcaaccgagagtcggtggaga	10	11	8	12	2	3	2	1	0	2	2	5	4	4	2	4	2	1	0	4	2	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:46867429C>T	uc010wlo.1	-	11	1299	c.1264G>A	c.(1264-1266)GAT>AAT	p.D422N	TTLL6_uc002iob.2_Missense_Mutation_p.D115N|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Missense_Mutation_p.D175N|TTLL6_uc002iod.2_Missense_Mutation_p.D269N	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	374	TTL.					cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						ACCTCTTTATCCAACCGAGAG	0.512													19	68					0	0	0	0	T	46867429	T	T	46867429	3	4	142	1	0	0	0	0	1	0	0	0	16799	855	30	2	1435	2	TTLL6	17	46867429	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	731604	46867429	34327781	273	26160											
C17orf47	284083	broad.mit.edu	37	chr17	56620420	56620420	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtaatttctgggggtttttgGgtttgctgtttatagatggg	5	19	15	2	0	1	1	0	0	1	1	1	1	1	1	0	4	1	5	0	4	3	8			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:56620420G>C	uc002iwq.1	-	1	1264	c.1128C>G	c.(1126-1128)ACC>ACG	p.T376T	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	376										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGGTTTTTGGGTTTGCTGTT	0.493													13	61					0	0	0	0	C	56620420	C	C	56620420	2	2	142	1	0	0	0	0	0	0	0	1	1865	1219	43	4		4	C17orf47	17	56620420	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	9752991	56620420	24574790	274	26161											
ERN1	2081	broad.mit.edu	37	chr17	62122729	62122729	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcatgatcacctgtctggagGgggacagtgatgttctcccg	7	10	14	10	1	3	2	1	2	2	0	4	4	3	4	2	3	0	2	2	3	0	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:62122729G>A	uc002jdz.2	-	20	2756	c.2643C>T	c.(2641-2643)CCC>CCT	p.P881P		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	881	Cytoplasmic (Potential).|KEN.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						CTGTCTGGAGGGGGACAGTGA	0.562													6	37					0	0	0	0	A	62122729	A	A	62122729	2	1	142	1	0	0	0	0	0	0	0	1	5261	1219	43	4		4	ERN1	17	62122729	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	5502309	62122729	19072481	275	26162											
CCDC46	201134	broad.mit.edu	37	chr17	64059084	64059084	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tattttatgtagcttaccttTttttcccagtcattatttag	8	22	4	7	0	1	0	1	0	0	0	2	0	2	0	2	0	2	2	2	0	6	11			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:64059084T>A	uc002jfl.2	-	11	1290	c.1071A>T	c.(1069-1071)AAA>AAT	p.K357N	CCDC46_uc010deo.2_Missense_Mutation_p.K99N|CCDC46_uc002jfm.2_Missense_Mutation_p.K357N|CCDC46_uc010dep.2_Missense_Mutation_p.K315N	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	357	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			AGCTTACCTTTTTTTCCCAGT	0.299													7	35					0	0	0	0	A	64059084	A	A	64059084	3	1	142	1	0	0	0	0	1	0	0	0	2830	1838	64	5	2030	5	CCDC46	17	64059084	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	1936355	64059084	17136126	276	26163											
GPR142	350383	broad.mit.edu	37	chr17	72368159	72368159	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgcaccatcgggccgcctCgtccccaggccggacccgcc	4	4	11	22	5	0	0	0	0	0	0	3	1	1	1	9	3	1	1	9	3	0	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:72368159C>T	uc010wqy.1	+	4	809	c.809C>T	c.(808-810)TCG>TTG	p.S270L	GPR142_uc010wqx.1_Missense_Mutation_p.S182L	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	270	Cytoplasmic (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CGGGCCGCCTCGTCCCCAGGC	0.657													5	24					0	0	0	0	T	72368159	T	T	72368159	3	4	142	1	0	0	0	0	1	0	0	0	6688	893	31	1	823	1	GPR142	17	72368159	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	8309075	72368159	8827051	277	26164											
GPRC5C	55890	broad.mit.edu	37	chr17	72443133	72443133	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccgaaagacggcaagaactCtcaggtctttagaaacccct	13	7	9	12	2	2	3	1	0	2	3	3	4	2	3	3	2	2	1	3	2	5	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:72443133C>G	uc002jks.2	+	3	1331	c.1292C>G	c.(1291-1293)TCT>TGT	p.S431C	GPRC5C_uc002jkp.2_Missense_Mutation_p.S476C|GPRC5C_uc002jkq.2_3'UTR|GPRC5C_uc002jkr.2_Missense_Mutation_p.S443C|GPRC5C_uc002jkt.2_Missense_Mutation_p.S431C|GPRC5C_uc002jku.2_Missense_Mutation_p.S186C	NM_018653	NP_061123	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	431	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5						GGCAAGAACTCTCAGGTCTTT	0.652													16	91					0	0	0	0	G	72443133	G	G	72443133	3	3	142	1	0	0	0	0	1	0	0	0	6765	913	32	2	1449	2	GPRC5C	17	72443133	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	74974	72443133	8752077	278	26165											
CASKIN2	57513	broad.mit.edu	37	chr17	73498200	73498200	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcttaacagtgtctgattcCgtgaggttgaaatcgaggcc	9	11	12	9	3	1	3	0	3	1	0	3	4	2	3	2	2	1	2	2	2	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr17:73498200C>A	uc002joc.2	-	18	3505	c.2955G>T	c.(2953-2955)ACG>ACT	p.T985T	CASKIN2_uc010wsc.1_Silent_p.T903T	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	985	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGTCTGATTCCGTGAGGTTGA	0.667													17	71					4.96729e-08	1.02027e-07	1	0	A	73498200	A	A	73498200	2	1	142	1	0	0	0	0	0	0	0	1	2679	639	23	3		3	CASKIN2	17	73498200	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	1055067	73498200	7697010	279	26166											
EPB41L3	23136	broad.mit.edu	37	chr18	5397146	5397146	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgggaagcagcggctgtctCttcctgttccaggacagctt	7	10	12	12	2	1	0	0	0	1	0	4	2	3	2	2	3	3	4	2	3	1	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr18:5397146C>G	uc002kmt.1	-	18	2838	c.2752G>C	c.(2752-2754)GAG>CAG	p.E918Q	EPB41L3_uc010wzh.1_Missense_Mutation_p.E749Q|EPB41L3_uc002kmu.1_Missense_Mutation_p.E696Q|EPB41L3_uc010dkq.1_Missense_Mutation_p.E587Q|EPB41L3_uc002kms.1_Missense_Mutation_p.E153Q|EPB41L3_uc010wze.1_Missense_Mutation_p.E223Q|EPB41L3_uc010wzf.1_Missense_Mutation_p.E215Q|EPB41L3_uc010wzg.1_Missense_Mutation_p.E190Q|EPB41L3_uc010dkr.2_Missense_Mutation_p.E310Q	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	918	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GCGGCTGTCTCTTCCTGTTCC	0.522													6	136					0	0	0	0	G	5397146	G	G	5397146	3	3	142	1	0	0	0	0	1	0	0	0	5178	922	32	2	531	2	EPB41L3	18	5397146	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08		5397146	72680102	280	26167											
C18orf45	85019	broad.mit.edu	37	chr18	20979546	20979546	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaccagtctggacaatgctCtggacccagcatagattata	12	11	8	10	0	2	1	0	0	2	1	2	3	2	3	2	2	3	2	2	2	5	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr18:20979546C>G	uc002kuf.2	-	4	372	c.263G>C	c.(262-264)AGA>ACA	p.R88T	C18orf45_uc010xaq.1_Intron|C18orf45_uc010xar.1_RNA|C18orf45_uc002kug.2_RNA|C18orf45_uc002kuh.2_RNA	NM_032933	NP_116322	Q24JQ0	CR045_HUMAN	hypothetical protein LOC85019	88						integral to membrane					0	all_cancers(21;0.000238)|all_epithelial(16;5.29e-06)|Lung NSC(20;0.00925)|Colorectal(14;0.0202)|all_lung(20;0.0255)|Ovarian(20;0.127)					GGACAATGCTCTGGACCCAGC	0.443													8	69					0	0	0	0	G	20979546	G	G	20979546	3	3	142	1	0	0	0	0	1	0	0	0	1912	913	32	2	675	2	C18orf45	18	20979546	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	15582400	20979546	57097702	281	26168											
ZNF521	25925	broad.mit.edu	37	chr18	22806305	22806305	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taatatgctcttccagggaaGagtcagtgagaaaccccata	14	9	9	9	0	2	2	1	1	1	2	3	4	3	3	3	1	2	1	3	1	5	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr18:22806305G>C	uc002kvk.2	-	4	1824	c.1577C>G	c.(1576-1578)TCT>TGT	p.S526C	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.S526C|ZNF521_uc002kvl.2_Missense_Mutation_p.S306C	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	526	C2H2-type 12.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TTCCAGGGAAGAGTCAGTGAG	0.468			T	PAX5	ALL								7	70					0	0	0	0	C	22806305	C	C	22806305	3	2	142	1	0	0	0	0	1	0	0	0	18032	942	33	2	2378	2	ZNF521	18	22806305	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1826759	22806305	55270943	282	26169											
MOCOS	55034	broad.mit.edu	37	chr18	33828964	33828964	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcagggtctgtgctgacagGtgagactctgaagcacgtga	10	8	15	8	1	2	4	0	4	2	1	2	5	2	4	0	2	3	3	0	2	1	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr18:33828964G>T	uc002kzq.3	+	10	2062	c.2039_splice	c.e10+1	p.R680_splice		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase						Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GTGCTGACAGGTGAGACTCTG	0.413													7	21					8.12818e-05	0.000156711	1	0	T	33828964	T	T	33828964	5	4	142	1	0	0	0	0	0	0	1	0	9742	1275	44	4	2078	4	MOCOS	18	33828964	Splice_Site	SNP	G	TCGA-CR-7371-01A-11D-2012-08	11022659	33828964	44248284	283	26170											
FAM69C	125704	broad.mit.edu	37	chr18	72103843	72103843	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttcccactggggaccccagGgtctgcacattcctgcaccg	6	8	11	16	1	1	0	0	0	1	0	3	1	3	1	5	3	2	3	5	3	0	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr18:72103843G>C	uc002llk.2	-	4	1162	c.1153C>G	c.(1153-1155)CCT>GCT	p.P385A		NM_001044369	NP_001037834	Q0P6D2	FA69C_HUMAN	hypothetical protein LOC125704	385	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0						GGGACCCCAGGGTCTGCACAT	0.587													6	21					0	0	0	0	C	72103843	C	C	72103843	3	2	142	1	0	0	0	0	1	0	0	0	5636	1232	43	4	110	4	FAM69C	18	72103843	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	38274879	72103843	5973405	284	26171											
POLRMT	5442	broad.mit.edu	37	chr19	619032	619032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcgatagggctggatgaCggggacgcccaggggtgtga	8	5	20	8	3	0	2	0	2	0	0	0	5	0	4	1	7	0	1	1	7	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:619032C>T	uc002lpf.1	-	15	3288	c.3232G>A	c.(3232-3234)GTC>ATC	p.V1078I		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	1078	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTGGATGACGGGGACGCCC	0.632													4	19					0	0	0	0	T	619032	T	T	619032	3	4	142	1	0	0	0	0	1	0	0	0	12293	536	19	1	488	1	POLRMT	19	619032	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08		619032	58509951	285	26172											
ABCA7	10347	broad.mit.edu	37	chr19	1043352	1043352	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccccgcctgctcggagctGattggagccctggacagcca	6	6	14	15	2	0	1	0	1	0	0	1	4	0	4	5	4	4	2	5	4	0	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:1043352G>C	uc002lqw.3	+	9	1041	c.810G>C	c.(808-810)CTG>CTC	p.L270L	ABCA7_uc010dsb.1_Silent_p.L132L	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	270	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity	p.L270L(1)		pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCGGAGCTGATTGGAGCCC	0.627													12	79					0	0	0	0	C	1043352	C	C	1043352	2	2	142	1	0	0	0	0	0	0	0	1	37	1277	45	2		2	ABCA7	19	1043352	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	424320	1043352	58085631	286	26173											
FZR1	51343	broad.mit.edu	37	chr19	3527705	3527705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaaggtgctggacgcgcccGagctgcaggacgacttctac	8	7	13	13	4	2	0	1	0	1	0	2	4	2	2	1	3	4	3	1	3	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:3527705G>A	uc010dtk.2	+	6	581	c.547G>A	c.(547-549)GAG>AAG	p.E183K	FZR1_uc002lxt.2_Missense_Mutation_p.E183K|FZR1_uc002lxv.2_Intron	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	183	WD 1.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACGCGCCCGAGCTGCAGGA	0.632													6	42					0	0	0	0	A	3527705	A	A	3527705	3	1	142	1	0	0	0	0	1	0	0	0	6172	1059	37	1	569	1	FZR1	19	3527705	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	2484353	3527705	55601278	287	26174											
SEMA6B	10501	broad.mit.edu	37	chr19	4548323	4548323	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaggaagacactgagcccaGacgtccctgaggtgctggca	10	5	13	13	1	0	4	0	2	0	2	1	5	1	5	3	3	2	2	3	3	1	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:4548323G>C	uc010duc.1	-	12	1444	c.1406C>G	c.(1405-1407)TCT>TGT	p.S469C	SEMA6B_uc010dud.2_Missense_Mutation_p.S469C|SEMA6B_uc010xih.1_Missense_Mutation_p.S469C	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	469	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTGAGCCCAGACGTCCCTGA	0.647													8	61					0	0	0	0	C	4548323	C	C	4548323	3	2	142	1	0	0	0	0	1	0	0	0	14105	942	33	2	1280	2	SEMA6B	19	4548323	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1020618	4548323	54580660	288	26175											
FEM1A	55527	broad.mit.edu	37	chr19	4792971	4792971	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgctgatcaccgacccggatGagatgcgcatgcaggccctg	8	6	13	14	4	1	2	1	2	0	1	1	5	1	3	3	2	2	3	3	2	0	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:4792971G>A	uc002mbf.2	+	1	1244	c.1105G>A	c.(1105-1107)GAG>AAG	p.E369K	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	369					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CGACCCGGATGAGATGCGCAT	0.632													16	61					0	0	0	0	A	4792971	A	A	4792971	3	1	142	1	0	0	0	0	1	0	0	0	5841	1291	45	2	1107	2	FEM1A	19	4792971	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	244648	4792971	54336012	289	26176											
MUC16	94025	broad.mit.edu	37	chr19	9056573	9056573	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggctcgtggaactccagtGgtggcaaatgaagtcatggc	10	9	14	8	1	1	1	1	1	0	0	3	2	2	2	1	5	1	2	1	5	3	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:9056573G>A	uc002mkp.2	-	3	31077	c.30873C>T	c.(30871-30873)ACC>ACT	p.T10291T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10293	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAACTCCAGTGGTGGCAAATG	0.517													10	92					0	0	0	0	A	9056573	A	A	9056573	2	1	142	1	0	0	0	0	0	0	0	1	10026	1335	47	4		4	MUC16	19	9056573	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	4263602	9056573	50072410	290	26177											
MUC16	94025	broad.mit.edu	37	chr19	9068476	9068476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatgtggctttatatgggtCtgagtcaggtgagacagtaa	10	12	15	4	0	2	2	1	2	1	1	2	4	2	3	0	4	0	2	0	4	3	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:9068476C>T	uc002mkp.2	-	3	19174	c.18970G>A	c.(18970-18972)GAC>AAC	p.D6324N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6326	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTATATGGGTCTGAGTCAGGT	0.443													9	79					0	0	0	0	T	9068476	T	T	9068476	3	4	142	1	0	0	0	0	1	0	0	0	10026	913	32	2	24881	2	MUC16	19	9068476	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	11903	9068476	50060507	291	26178											
ZNF136	7695	broad.mit.edu	37	chr19	12297490	12297490	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaagaaaatccctggagtGaaactctgtgaaagcattgt	15	9	10	7	0	1	3	0	2	1	1	2	4	2	4	1	1	3	2	1	1	5	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:12297490G>A	uc002mti.2	+	4	397	c.297G>A	c.(295-297)GTG>GTA	p.V99V	ZNF136_uc010xmh.1_Silent_p.V33V	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	99					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						TCCCTGGAGTGAAACTCTGTG	0.398													5	33					0	0	0	0	A	12297490	A	A	12297490	2	1	142	1	0	0	0	0	0	0	0	1	17793	1277	45	2		2	ZNF136	19	12297490	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	3229014	12297490	46831493	292	26179											
ZNF85	7639	broad.mit.edu	37	chr19	21132951	21132951	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctacacatgtgaagaatgtgGcaaagcctttaaccagtcct	13	10	8	10	0	0	2	0	1	0	1	1	2	1	2	3	1	3	1	3	1	5	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:21132951G>A	uc002npg.3	+	4	1758	c.1631G>A	c.(1630-1632)GGC>GAC	p.G544D	ZNF85_uc010ecn.2_Missense_Mutation_p.G479D|ZNF85_uc010eco.2_Missense_Mutation_p.G492D|ZNF85_uc002npi.2_Missense_Mutation_p.G485D	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	544	C2H2-type 15.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1						GAAGAATGTGGCAAAGCCTTT	0.348													5	41					0	0	0	0	A	21132951	A	A	21132951	3	1	142	1	0	0	0	0	1	0	0	0	18260	1203	42	4	1645	4	ZNF85	19	21132951	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	8835461	21132951	37996032	293	26180											
ZNF431	170959	broad.mit.edu	37	chr19	21365549	21365549	+	Frame_Shift_Del	DEL	C	-	-																															tttacagttaagaaaaggctCcgcaagtgtagatgagtata																										TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:21365549delC	uc002npp.2	+	5	590	c.443delC	c.(442-444)TCCfs	p.S148fs	ZNF431_uc010ecq.2_Frame_Shift_Del_p.S57fs|ZNF431_uc010ecr.2_Frame_Shift_Del_p.S149fs	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						AGAAAAGGCTCCGCAAGTGTA	0.358													---	---	---								-	21365549	-	-	21365549	7	5	142	1	0	1	0	1	0	0	0	0	17972	855	30	0	461	0	ZNF431	19	21365549	Frame_Shift_Del	DEL	C	TCGA-CR-7371-01A-11D-2012-08	232598	21365549	37763434	294	26181											
ZNF98	148198	broad.mit.edu	37	chr19	22575547	22575547	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttgaatttgaaaatttatGaaagactttcacatatttgt	14	18	6	3	0	1	4	1	3	0	1	1	4	1	4	0	0	0	1	0	0	6	7			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:22575547G>A	uc002nqt.2	-	4	612	c.490C>T	c.(490-492)CAT>TAT	p.H164Y		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				GAAAATTTATGAAAGACTTTC	0.313													3	7					0	0	0	0	A	22575547	A	A	22575547	3	1	142	1	0	0	0	0	1	0	0	0	18270	1290	45	2	1232	2	ZNF98	19	22575547	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1209998	22575547	36553436	295	26182											
ZNF536	9745	broad.mit.edu	37	chr19	31039948	31039948	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctgatggaaaggcccactCtgaagaggatgtccccatcc	10	7	11	13	0	1	3	0	2	1	1	3	5	3	5	5	3	0	0	5	3	2	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:31039948C>G	uc002nsu.1	+	4	3560	c.3422C>G	c.(3421-3423)TCT>TGT	p.S1141C	ZNF536_uc010edd.1_Missense_Mutation_p.S1141C	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					AAGGCCCACTCTGAAGAGGAT	0.542													6	38					0	0	0	0	G	31039948	G	G	31039948	3	3	142	1	0	0	0	0	1	0	0	0	18041	913	32	2	3432	2	ZNF536	19	31039948	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	8464401	31039948	28089035	296	26183											
CHST8	64377	broad.mit.edu	37	chr19	34263714	34263714	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctgcagcccctgcctcatcGactacgatttcgtaggcaag	8	10	9	14	3	2	0	1	0	1	0	4	2	2	0	3	1	4	3	3	1	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:34263714G>A	uc002nus.3	+	5	1526	c.1021G>A	c.(1021-1023)GAC>AAC	p.D341N	CHST8_uc002nut.3_Missense_Mutation_p.D341N|CHST8_uc002nuu.2_Missense_Mutation_p.D341N	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	341	Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					CTGCCTCATCGACTACGATTT	0.607													13	34					0	0	0	0	A	34263714	A	A	34263714	3	1	142	1	0	0	0	0	1	0	0	0	3425	1058	37	1	1031	1	CHST8	19	34263714	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	3223766	34263714	24865269	297	26184											
ZNF565	147929	broad.mit.edu	37	chr19	36673999	36673999	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacagtgagttgggagccaCgaatgaaagccttgccacag	12	6	13	10	1	0	2	0	2	0	0	0	4	0	3	3	1	3	2	3	1	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:36673999C>T	uc002odn.2	-	5	977	c.869G>A	c.(868-870)CGT>CAT	p.R290H	ZNF565_uc010ees.2_Missense_Mutation_p.R225H|ZNF565_uc002odo.2_Missense_Mutation_p.R290H	NM_152477	NP_689690	Q8N9K5	ZN565_HUMAN	zinc finger protein 565	290	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)			TTGGGAGCCACGAATGAAAGC	0.502													14	81					0	0	0	0	T	36673999	T	T	36673999	3	4	142	1	0	0	0	0	1	0	0	0	18063	536	19	1	634	1	ZNF565	19	36673999	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	2410285	36673999	22454984	298	26185											
ZNF345	25850	broad.mit.edu	37	chr19	37367985	37367985	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcgacatcagcgaattcatActggtgagaaaccttatgaa	14	11	8	8	2	2	2	2	2	0	1	3	5	2	2	1	1	3	0	1	1	5	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:37367985A>G	uc002oex.2	+	3	631	c.253A>G	c.(253-255)ACT>GCT	p.T85A	ZNF345_uc002oey.3_Missense_Mutation_p.T85A|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	85					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GCGAATTCATACTGGTGAGAA	0.403													6	38					0	0	0	0	G	37367985	G	G	37367985	3	3	142	1	0	0	0	0	1	0	0	0	17926	391	14	5	255	5	ZNF345	19	37367985	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	693986	37367985	21760998	299	26186											
ZNF45	7596	broad.mit.edu	37	chr19	44417888	44417888	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccagaaaattggaggccCgacagaagcccttcccacac	12	5	10	14	1	0	2	0	0	0	2	1	4	1	3	4	2	2	0	4	2	3	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:44417888C>A	uc002oxu.1	-	4	1799	c.1700G>T	c.(1699-1701)CGG>CTG	p.R567L	ZNF45_uc002oxw.1_Missense_Mutation_p.R567L|ZNF45_uc002oxv.1_Missense_Mutation_p.R567L	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	567	C2H2-type 15.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						ATTGGAGGCCCGACAGAAGCC	0.517													17	85					3.41278e-10	7.15201e-10	1	0	A	44417888	A	A	44417888	3	1	142	1	0	0	0	0	1	0	0	0	17988	652	23	3	352	3	ZNF45	19	44417888	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	7049903	44417888	14711095	300	26187											
MYADM	91663	broad.mit.edu	37	chr19	54377171	54377171	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctatgtccagttcctgtccCacggccgttcgcgggaccac	5	9	10	17	4	0	0	0	0	0	0	4	1	3	1	6	2	0	2	6	2	1	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:54377171C>A	uc002qcl.2	+	3	536	c.388C>A	c.(388-390)CAC>AAC	p.H130N	MYADM_uc002qcm.2_Missense_Mutation_p.H130N|MYADM_uc002qcn.2_Missense_Mutation_p.H130N|MYADM_uc002qco.2_Missense_Mutation_p.H130N|MYADM_uc002qcp.2_Missense_Mutation_p.H130N	NM_001020820	NP_001018656	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	130	MARVEL 1.					integral to membrane				ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		GTTCCTGTCCCACGGCCGTTC	0.662													20	98					7.45023e-12	1.64223e-11	1	0	A	54377171	A	A	54377171	3	1	142	1	0	0	0	0	1	0	0	0	10059	594	21	4	390	4	MYADM	19	54377171	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	9959283	54377171	4751812	301	26188											
LILRB5	10990	broad.mit.edu	37	chr19	54756392	54756392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctctggccccgcagcccCtgcaggacggtagaaatggg	7	5	16	13	2	1	1	0	0	1	1	1	2	1	2	4	5	2	4	4	5	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:54756392C>T	uc002qex.2	-	10	1603	c.1492G>A	c.(1492-1494)GGG>AGG	p.G498R	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.G490R|LILRB5_uc002qey.2_Missense_Mutation_p.G499R|LILRB5_uc002qez.2_Missense_Mutation_p.G399R|LILRB5_uc002qfa.1_3'UTR	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	498	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCCGCAGCCCCTGCAGGACGG	0.607													8	76					0	0	0	0	T	54756392	T	T	54756392	3	4	142	1	0	0	0	0	1	0	0	0	8835	681	24	4	296	4	LILRB5	19	54756392	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	379221	54756392	4372591	302	26189											
LILRA1	11024	broad.mit.edu	37	chr19	55106219	55106219	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctggtgtcaggggatcctgGagacccaggagtaccgtctg	7	9	15	10	1	3	1	1	0	2	1	4	4	4	3	3	5	1	1	3	5	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:55106219G>A	uc002qgh.1	+	4	342	c.160G>A	c.(160-162)GAG>AAG	p.E54K	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.E54K	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	54	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GGGGATCCTGGAGACCCAGGA	0.577													19	91					0	0	0	0	A	55106219	A	A	55106219	3	1	142	1	0	0	0	0	1	0	0	0	8825	1175	41	2	170	2	LILRA1	19	55106219	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	349827	55106219	4022764	303	26190											
LILRB1	10859	broad.mit.edu	37	chr19	55148286	55148286	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatcccaggaagggccctCtccagctgtgcccagcatct	7	8	9	17	0	2	0	0	0	2	0	5	1	4	1	5	2	3	2	5	2	1	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr19:55148286C>T	uc002qgj.2	+	16	2250	c.1910C>T	c.(1909-1911)TCT>TTT	p.S637F	LILRB1_uc002qgl.2_Missense_Mutation_p.S638F|LILRB1_uc002qgk.2_Missense_Mutation_p.S638F|LILRB1_uc002qgm.2_Missense_Mutation_p.S639F|LILRB1_uc010erq.2_Missense_Mutation_p.S621F|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	637	Cytoplasmic (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GAAGGGCCCTCTCCAGCTGTG	0.642										HNSCC(37;0.09)			17	47					0	0	0	0	T	55148286	T	T	55148286	3	4	142	1	0	0	0	0	1	0	0	0	8831	913	32	2	1970	2	LILRB1	19	55148286	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	42067	55148286	3980697	304	26191											
CPXM1	56265	broad.mit.edu	37	chr20	2775946	2775946	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaggtaggtgaggagggCgtctttgttgttctcccact	5	13	13	10	1	2	1	0	1	2	0	4	2	3	2	2	4	0	3	2	4	1	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:2775946C>A	uc002wgu.2	-	12	1901	c.1837G>T	c.(1837-1839)GCC>TCC	p.A613S	CPXM1_uc010gas.2_Missense_Mutation_p.A539S	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	613					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						GTGAGGAGGGCGTCTTTGTTG	0.517													6	43					8.12818e-05	0.000156711	1	0	A	2775946	A	A	2775946	3	1	142	1	0	0	0	0	1	0	0	0	3852	768	27	3	379	3	CPXM1	20	2775946	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08		2775946	60249574	305	26192											
ADAM33	80332	broad.mit.edu	37	chr20	3655732	3655732	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggccgtagtgggtttctatgTatcctggggccagcagcctg	5	11	15	10	1	1	0	0	0	1	0	2	0	2	0	4	4	2	4	4	4	3	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:3655732T>A	uc002wit.2	-	4	362	c.275A>T	c.(274-276)TAC>TTC	p.Y92F	ADAM33_uc002wir.1_Missense_Mutation_p.Y92F|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Missense_Mutation_p.Y92F|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Missense_Mutation_p.Y91F|ADAM33_uc010zqg.1_Missense_Mutation_p.Y91F|ADAM33_uc010zqh.1_Missense_Mutation_p.Y92F	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	92	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						GGTTTCTATGTATCCTGGGGC	0.602													21	52					0	0	0	0	A	3655732	A	A	3655732	3	1	142	1	0	0	0	0	1	0	0	0	250	1638	57	5	2242	5	ADAM33	20	3655732	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	879786	3655732	59369788	306	26193											
C20orf12	55184	broad.mit.edu	37	chr20	18393348	18393348	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcactcattttctcctgcctCtgcttttgagaggctagttc	5	17	7	12	0	4	1	2	1	2	1	6	2	4	1	2	1	2	3	2	1	1	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:18393348C>G	uc010zsa.1	-	13	1640	c.1431G>C	c.(1429-1431)CAG>CAC	p.Q477H	C20orf12_uc010zrz.1_5'UTR|C20orf12_uc002wqp.3_Missense_Mutation_p.Q168H|C20orf12_uc002wqr.3_RNA|C20orf12_uc002wqs.3_Missense_Mutation_p.Q344H|C20orf12_uc002wqq.3_Missense_Mutation_p.Q458H	NM_001099407	NP_001092877	Q9NVP4	CT012_HUMAN	hypothetical protein LOC55184	285						intracellular	zinc ion binding			ovary(1)	1		Myeloproliferative disorder(85;0.0122)				TCTCCTGCCTCTGCTTTTGAG	0.517													19	174					0	0	0	0	G	18393348	G	G	18393348	3	3	142	1	0	0	0	0	1	0	0	0	2095	912	32	2	920	2	C20orf12	20	18393348	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	14737616	18393348	44632172	307	26194											
BPIL3	128859	broad.mit.edu	37	chr20	31620830	31620830	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagtcatatcctggagaaGatggcagccgaggcaggcaa	13	5	15	8	1	1	3	1	0	0	3	2	6	2	3	2	4	1	3	2	4	3	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:31620830G>A	uc010zuc.1	+	2	138	c.138G>A	c.(136-138)AAG>AAA	p.K46K	BPIL3_uc010zud.1_5'UTR	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	46						extracellular region	lipid binding			ovary(1)|pancreas(1)	2						TCCTGGAGAAGATGGCAGCCG	0.557													16	87					0	0	0	0	A	31620830	A	A	31620830	2	1	142	1	0	0	0	0	0	0	0	1	1498	933	33	2		2	BPIL3	20	31620830	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	13227482	31620830	31404690	308	26195											
ZNF831	128611	broad.mit.edu	37	chr20	57767508	57767508	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacctggacgcccccagaCaagtctcggcccctcttctt	6	9	7	19	2	3	1	0	0	3	1	5	2	4	2	6	2	0	0	6	2	1	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr20:57767508C>G	uc002yan.2	+	1	1434	c.1434C>G	c.(1432-1434)GAC>GAG	p.D478E		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	478						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CGCCCCCAGACAAGTCTCGGC	0.662													13	47					0	0	0	0	G	57767508	G	G	57767508	3	3	142	1	0	0	0	0	1	0	0	0	18252	477	17	4	1436	4	ZNF831	20	57767508	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	26146678	57767508	5258012	309	26196											
KRTAP20-1	337975	broad.mit.edu	37	chr21	31988891	31988891	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctatggaggctatggaaatGgctactactgcccatcttgc	9	11	11	10	0	1	0	0	0	1	0	1	2	1	2	1	4	4	3	1	4	5	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr21:31988891G>T	uc011ade.1	+	1	118	c.118G>T	c.(118-120)GGC>TGC	p.G40C	KRTAP6-1_uc002yop.2_5'Flank	NM_181615	NP_853646	Q3LI63	KR201_HUMAN	keratin associated protein 20-1	40						intermediate filament				breast(1)	1						CTATGGAAATGGCTACTACTG	0.463													11	42					1.08611e-07	2.22452e-07	1	0	T	31988891	T	T	31988891	3	4	142	1	0	0	0	0	1	0	0	0	8575	1348	47	4	120	4	KRTAP20-1	21	31988891	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08		31988891	16141004	310	26197											
ADARB1	104	broad.mit.edu	37	chr21	46596174	46596174	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgaaactcctgacaaggcGgagcctcccttttacgtggg	8	11	11	11	2	0	2	0	2	0	0	2	3	2	3	3	3	3	0	3	3	3	3	rs146135960	byFrequency	TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr21:46596174G>A	uc002zgy.2	+	4	993	c.558G>A	c.(556-558)GCG>GCA	p.A186A	ADARB1_uc002zgr.2_Silent_p.A186A|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Silent_p.A186A|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Silent_p.A186A|ADARB1_uc010gpx.2_Intron|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA|ADARB1_uc011afo.1_Silent_p.A235A	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	186					adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		CTGACAAGGCGGAGCCTCCCT	0.592													6	26					0	0	0	0	A	46596174	A	A	46596174	2	1	142	1	0	0	0	0	0	0	0	1	282	1103	39	1		1	ADARB1	21	46596174	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	14607283	46596174	1533721	311	26198											
XKR3	150165	broad.mit.edu	37	chr22	17288660	17288660	+	Frame_Shift_Del	DEL	A	-	-																															tcctaaaagaagaatgtgccAaaaaagtaatgcagccttat																										TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:17288660delA	uc002zlv.2	-	2	402	c.304delT	c.(304-306)TGGfs	p.W102fs	XKR3_uc011agf.1_Frame_Shift_Del_p.W102fs	NM_175878	NP_787074	Q5GH77	XKR3_HUMAN	X Kell blood group precursor-related family,	102	Helical; (Potential).					integral to membrane|plasma membrane				large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGAATGTGCCAAAAAAGTAAT	0.333													---	---	---								-	17288660	-	-	17288660	7	5	142	1	0	1	0	1	0	0	0	0	17500	130	5	0	1087	0	XKR3	22	17288660	Frame_Shift_Del	DEL	A	TCGA-CR-7371-01A-11D-2012-08		17288660	34015906	312	26199											
PI4KA	5297	broad.mit.edu	37	chr22	21064999	21064999	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggctcaccgcacagccaggTagcctcggacacacatctcc	10	5	9	17	2	2	0	1	0	1	0	4	1	2	1	4	3	2	3	4	3	1	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:21064999T>C	uc002zsz.3	-	52	6128	c.5897A>G	c.(5896-5898)TAC>TGC	p.Y1966C	PI4KA_uc010gsp.2_Missense_Mutation_p.Y357C|PI4KA_uc002zsy.3_Missense_Mutation_p.Y776C	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	1966	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CACAGCCAGGTAGCCTCGGAC	0.587													40	171					0	0	0	0	C	21064999	C	C	21064999	3	2	142	1	0	0	0	0	1	0	0	0	11928	1638	57	5	253	5	PI4KA	22	21064999	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	3776339	21064999	30239567	313	26200											
HIC2	23119	broad.mit.edu	37	chr22	21799710	21799710	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcatccaagctcggtatCaggggctcgtggatgggcgc	6	9	15	11	3	2	0	2	0	0	0	5	1	3	1	1	5	1	3	1	5	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:21799710C>T	uc002zur.3	+	3	756	c.526C>T	c.(526-528)CAG>TAG	p.Q176*	HIC2_uc002zus.3_Nonsense_Mutation_p.Q176*	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	176				Q -> R (in Ref. 3; BAA82972).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				AGCTCGGTATCAGGGGCTCGT	0.677													14	12					0	0	0	0	T	21799710	T	T	21799710	4	4	142	1	0	0	0	0	0	1	0	0	7141	827	29	2	532	2	HIC2	22	21799710	Nonsense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	734711	21799710	29504856	314	26201											
ZNRF3	84133	broad.mit.edu	37	chr22	29442723	29442723	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaattccatgaacaggctggCtgtgcaggctctagagaaga	12	8	13	8	0	1	3	0	1	1	2	2	5	2	3	1	3	2	4	1	3	4	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:29442723C>A	uc003aeg.2	+	6	629	c.464C>A	c.(463-465)GCT>GAT	p.A155D	ZNRF3_uc003aeh.1_Missense_Mutation_p.A155D	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	255	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						AACAGGCTGGCTGTGCAGGCT	0.562													50	131					4.86159e-25	1.14121e-24	1	0	A	29442723	A	A	29442723	3	1	142	1	0	0	0	0	1	0	0	0	18280	797	28	4	482	4	ZNRF3	22	29442723	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	7643013	29442723	21861843	315	26202											
MTMR3	8897	broad.mit.edu	37	chr22	30412531	30412531	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccataggtgaaactggtgcaGcatacctattcctgcctgtt	9	12	9	11	0	0	1	0	1	0	0	1	1	1	1	4	2	5	3	4	2	4	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:30412531G>A	uc003agv.3	+	15	1846	c.1518G>A	c.(1516-1518)CAG>CAA	p.Q506Q	MTMR3_uc003agu.3_Silent_p.Q506Q|MTMR3_uc003agw.3_Silent_p.Q506Q	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	506	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			AACTGGTGCAGCATACCTATT	0.478													39	120					0	0	0	0	A	30412531	A	A	30412531	2	1	142	1	0	0	0	0	0	0	0	1	9998	962	34	4		4	MTMR3	22	30412531	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	969808	30412531	20892035	316	26203											
PES1	23481	broad.mit.edu	37	chr22	30977575	30977575	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagttgacaaagcccagcagCgtggtgtagaactcggtgaa	13	7	13	8	2	0	3	0	2	0	1	1	3	0	3	1	2	4	3	1	2	5	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:30977575C>T	uc003aij.1	-	7	761	c.687G>A	c.(685-687)ACG>ACA	p.T229T	PES1_uc003aik.1_Silent_p.T229T|PES1_uc003ail.1_Silent_p.T212T|PES1_uc003aim.1_Silent_p.T229T|PES1_uc003ain.1_Silent_p.T90T|PES1_uc003aio.1_Silent_p.T90T	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	229	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						AGCCCAGCAGCGTGGTGTAGA	0.597													5	34					0	0	0	0	T	30977575	T	T	30977575	2	4	142	1	0	0	0	0	0	0	0	1	11787	755	27	1		1	PES1	22	30977575	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	565044	30977575	20326991	317	26204											
DEPDC5	9681	broad.mit.edu	37	chr22	32217595	32217595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actcctctgcagagctgctgGagttagcatatcatgaagct	10	11	10	10	0	2	2	1	1	1	1	3	3	3	3	1	1	5	6	1	1	3	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:32217595G>A	uc003als.2	+	23	2120	c.1978G>A	c.(1978-1980)GAG>AAG	p.E660K	DEPDC5_uc011als.1_Intron|DEPDC5_uc011alu.1_Missense_Mutation_p.E660K|DEPDC5_uc011alv.1_Intron|DEPDC5_uc003alt.2_Missense_Mutation_p.E660K|DEPDC5_uc003alu.2_Missense_Mutation_p.E100K|DEPDC5_uc003alv.2_Intron|DEPDC5_uc011alw.1_5'Flank|DEPDC5_uc011alt.1_Intron	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	660					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						AGAGCTGCTGGAGTTAGCATA	0.557													24	217					0	0	0	0	A	32217595	A	A	32217595	3	1	142	1	0	0	0	0	1	0	0	0	4464	1175	41	2	2082	2	DEPDC5	22	32217595	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1240020	32217595	19086971	318	26205											
MPPED1	758	broad.mit.edu	37	chr22	43821067	43821067	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcccctgcggcctgggcatgGcattctcccagtcccacgtg	4	9	11	17	2	1	0	0	0	1	0	4	0	3	0	5	3	1	2	5	3	0	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:43821067G>C	uc011apv.1	+	2	299	c.76G>C	c.(76-78)GCA>CCA	p.A26P	MPPED1_uc011apw.1_Intron|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Missense_Mutation_p.A26P|MPPED1_uc011apz.1_Missense_Mutation_p.A59P	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	26							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				CCTGGGCATGGCATTCTCCCA	0.697													12	22					0	0	0	0	C	43821067	C	C	43821067	3	2	142	1	0	0	0	0	1	0	0	0	9794	1203	42	4	78	4	MPPED1	22	43821067	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	11603472	43821067	7483499	319	26206											
PARVG	64098	broad.mit.edu	37	chr22	44585010	44585010	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagagaggctggcggcgctCaagctggaagcagaggacat	11	4	16	10	2	1	2	1	0	0	2	1	5	1	4	1	5	2	4	1	5	2	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:44585010C>T	uc011aqe.1	+	6	688	c.264C>T	c.(262-264)CTC>CTT	p.L88L	PARVG_uc003bep.2_Silent_p.L88L|PARVG_uc011aqf.1_Silent_p.L88L|PARVG_uc003beq.2_RNA|PARVG_uc003ber.2_RNA	NM_001137605	NP_001131077	Q9HBI0	PARVG_HUMAN	parvin, gamma	88	CH 1.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding				0		Ovarian(80;0.024)|all_neural(38;0.0299)				TGGCGGCGCTCAAGCTGGAAG	0.652													5	61					0	0	0	0	T	44585010	T	T	44585010	2	4	142	1	0	0	0	0	0	0	0	1	11524	813	29	2		2	PARVG	22	44585010	Silent	SNP	C	TCGA-CR-7371-01A-11D-2012-08	763943	44585010	6719556	320	26207											
GRAMD4	23151	broad.mit.edu	37	chr22	47033858	47033858	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attggaaaaacatttcttacGtgagtaccagaaagcgcttg	14	11	9	7	2	1	2	0	1	1	1	1	3	1	3	1	1	4	2	1	1	5	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:47033858G>T	uc003bhx.2	+	2	322	c.283_splice	c.e2+1	p.Q95_splice	GRAMD4_uc010had.2_Splice_Site_p.Q34_splice	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein						apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		CATTTCTTACGTGAGTACCAG	0.522													31	94					9.04072e-19	2.08167e-18	1	0	T	47033858	T	T	47033858	5	4	142	1	0	0	0	0	0	0	1	0	6791	1159	40	3	290	3	GRAMD4	22	47033858	Splice_Site	SNP	G	TCGA-CR-7371-01A-11D-2012-08	2448848	47033858	4270708	321	26208											
CERK	64781	broad.mit.edu	37	chr22	47095335	47095335	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgctgttgtggtggactGaggacacatccatggccagc	7	10	15	9	0	0	1	0	1	0	0	1	3	1	3	2	4	2	2	2	4	0	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chr22:47095335G>T	uc003bia.2	-	8	925	c.818C>A	c.(817-819)TCA>TAA	p.S273*	CERK_uc010hae.2_Nonsense_Mutation_p.S75*	NM_022766	NP_073603	Q8TCT0	CERK1_HUMAN	ceramide kinase	273	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			skin(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GTGGTGGACTGAGGACACATC	0.612													16	113					1.15088e-07	2.35052e-07	1	0	T	47095335	T	T	47095335	4	4	142	1	0	0	0	0	0	1	0	0	3282	1294	45	2	819	2	CERK	22	47095335	Nonsense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	61477	47095335	4209231	322	26209											
WWC3	55841	broad.mit.edu	37	chrX	10106854	10106854	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagctgaatgaggagctcTgcgccctccgtgagctgcgg	6	7	16	12	3	1	3	0	3	1	0	2	4	2	4	2	3	5	4	2	3	1	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:10106854T>A	uc004csx.3	+	21	3160	c.2962T>A	c.(2962-2964)TGC>AGC	p.C988S	WWC3_uc010nds.2_Missense_Mutation_p.C652S|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	988	Potential.									ovary(4)	4						TGAGGAGCTCTGCGCCCTCCG	0.677													7	28					0	0	0	0	A	10106854	A	A	10106854	3	1	142	1	0	0	0	0	1	0	0	0	17481	1580	55	5	3040	5	WWC3	23	10106854	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08		10106854	145163706	323	26210											
CLCN4	1183	broad.mit.edu	37	chrX	10176392	10176392	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgccatcactgccatcattgCctaccccaatccctacacac	10	9	3	19	0	2	0	2	0	0	0	3	0	3	0	6	0	5	0	6	0	3	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:10176392C>G	uc004csy.3	+	9	1581	c.1151C>G	c.(1150-1152)GCC>GGC	p.A384G	CLCN4_uc011mid.1_Missense_Mutation_p.A290G	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	384	Helical; (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GCCATCATTGCCTACCCCAAT	0.577													47	261					0	0	0	0	G	10176392	G	G	10176392	3	3	142	1	0	0	0	0	1	0	0	0	3480	739	26	4	1177	4	CLCN4	23	10176392	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	69538	10176392	145094168	324	26211											
FRMPD4	9758	broad.mit.edu	37	chrX	12736348	12736348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaggaagaaggagctcctGatggagaaaccagtgatggc	14	5	16	6	0	0	4	0	2	0	2	1	8	1	7	2	5	2	1	2	5	4	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:12736348G>A	uc004cuz.1	+	16	3909	c.3403G>A	c.(3403-3405)GAT>AAT	p.D1135N	FRMPD4_uc011mij.1_Missense_Mutation_p.D1127N	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1135					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGGAGCTCCTGATGGAGAAAC	0.512													34	273					0	0	0	0	A	12736348	A	A	12736348	3	1	142	1	0	0	0	0	1	0	0	0	6093	1290	45	2	3465	2	FRMPD4	23	12736348	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	2559956	12736348	142534212	325	26212											
ARX	170302	broad.mit.edu	37	chrX	25033720	25033720	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggcaagctctgcgcggcTcccagcaaccgcattttgca	8	7	11	15	3	1	0	0	0	1	0	2	0	2	0	2	2	5	7	2	2	2	2			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:25033720T>A	uc004dbp.3	-	1	346	c.135A>T	c.(133-135)GGA>GGT	p.G45G		NM_139058	NP_620689	Q96QS3	ARX_HUMAN	aristaless related homeobox	45						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCTGCGCGGCTCCCAGCAACC	0.607													5	24					0	0	0	0	A	25033720	A	A	25033720	2	1	142	1	0	0	0	0	0	0	0	1	1006	1538	54	5		5	ARX	23	25033720	Silent	SNP	T	TCGA-CR-7371-01A-11D-2012-08	12297372	25033720	130236840	326	26213											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29686564	29686564	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagcccctctgactgataagCcacccaagcttttgtatcct	9	11	6	15	0	1	2	0	2	1	0	2	2	2	2	5	0	3	2	5	0	3	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:29686564C>T	uc004dby.2	+	6	1229	c.721C>T	c.(721-723)CCA>TCA	p.P241S		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	241	Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						GACTGATAAGCCACCCAAGCT	0.368													4	32					0	0	0	0	T	29686564	T	T	29686564	3	4	142	1	0	0	0	0	1	0	0	0	7700	739	26	4	739	4	IL1RAPL1	23	29686564	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	4652844	29686564	125583996	327	26214											
DMD	1756	broad.mit.edu	37	chrX	31496268	31496268	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagagtcaatgaggagatcGcccacgggctgccaggatcc	11	5	14	11	2	1	3	1	1	0	2	3	6	2	4	3	3	1	1	3	3	1	0			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:31496268G>C	uc004dda.1	-	59	9136	c.8892C>G	c.(8890-8892)GGC>GGG	p.G2964G	DMD_uc004dcq.1_Silent_p.G235G|DMD_uc004dcr.1_Silent_p.G504G|DMD_uc004dcs.1_Silent_p.G504G|DMD_uc004dct.1_Silent_p.G504G|DMD_uc004dcu.1_Silent_p.G504G|DMD_uc004dcv.1_Silent_p.G504G|DMD_uc004dcw.2_Silent_p.G1620G|DMD_uc004dcx.2_Silent_p.G1623G|DMD_uc004dcz.2_Silent_p.G2841G|DMD_uc004dcy.1_Silent_p.G2960G|DMD_uc004ddb.1_Silent_p.G2956G	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2964	Spectrin 22.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGAGGAGATCGCCCACGGGCT	0.532													4	28					0	0	0	0	C	31496268	C	C	31496268	2	2	142	1	0	0	0	0	0	0	0	1	4602	1074	38	3		3	DMD	23	31496268	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	1809704	31496268	123774292	328	26215											
DMD	1756	broad.mit.edu	37	chrX	31496480	31496480	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacattctgggctctctcctCaggaggcagctctaaattgg	8	11	11	11	0	4	0	1	0	3	0	6	2	5	1	1	4	1	3	1	4	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:31496480C>G	uc004dda.1	-	59	8924	c.8680G>C	c.(8680-8682)GAG>CAG	p.E2894Q	DMD_uc004dcq.1_Missense_Mutation_p.E165Q|DMD_uc004dcr.1_Missense_Mutation_p.E434Q|DMD_uc004dcs.1_Missense_Mutation_p.E434Q|DMD_uc004dct.1_Missense_Mutation_p.E434Q|DMD_uc004dcu.1_Missense_Mutation_p.E434Q|DMD_uc004dcv.1_Missense_Mutation_p.E434Q|DMD_uc004dcw.2_Missense_Mutation_p.E1550Q|DMD_uc004dcx.2_Missense_Mutation_p.E1553Q|DMD_uc004dcz.2_Missense_Mutation_p.E2771Q|DMD_uc004dcy.1_Missense_Mutation_p.E2890Q|DMD_uc004ddb.1_Missense_Mutation_p.E2886Q	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2894	Spectrin 20.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GCTCTCTCCTCAGGAGGCAGC	0.443													17	83					0	0	0	0	G	31496480	G	G	31496480	3	3	142	1	0	0	0	0	1	0	0	0	4602	835	29	2	2575	2	DMD	23	31496480	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	212	31496480	123774080	329	26216											
ITIH5L	347365	broad.mit.edu	37	chrX	54823474	54823474	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acaggacagaggtgaccaagGtgtgggcatagcgagacacc	13	4	15	9	1	0	3	0	1	0	2	0	5	0	4	2	4	1	1	2	4	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:54823474G>A	uc004dtj.2	-	2	188	c.158C>T	c.(157-159)ACC>ATC	p.T53I		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	53	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GGTGACCAAGGTGTGGGCATA	0.473													11	34					0	0	0	0	A	54823474	A	A	54823474	3	1	142	1	0	0	0	0	1	0	0	0	7947	1261	44	4	3831	4	ITIH5L	23	54823474	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	23326994	54823474	100447086	330	26217											
SLC7A3	84889	broad.mit.edu	37	chrX	70146774	70146774	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggccagagagtggagtgggGatggagttgagtgggaaaaa	12	7	20	2	0	0	2	0	1	0	1	0	7	0	6	1	6	0	1	1	6	2	1			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:70146774G>A	uc004dyn.2	-	9	1562	c.1404C>T	c.(1402-1404)ATC>ATT	p.I468I	SLC7A3_uc004dyo.2_Silent_p.I468I	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	468	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GTGGAGTGGGGATGGAGTTGA	0.483													6	51					0	0	0	0	A	70146774	A	A	70146774	2	1	142	1	0	0	0	0	0	0	0	1	14762	1164	41	2		2	SLC7A3	23	70146774	Silent	SNP	G	TCGA-CR-7371-01A-11D-2012-08	15323300	70146774	85123786	331	26218											
KIAA2022	340533	broad.mit.edu	37	chrX	73964112	73964112	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagatggcattcacagaagCactattagcagcatgttcgg	12	9	12	8	1	1	2	1	0	0	2	2	3	1	2	0	3	3	5	0	3	3	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:73964112C>T	uc004eby.2	-	3	897	c.280G>A	c.(280-282)GCT>ACT	p.A94T		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	94					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTCACAGAAGCACTATTAGCA	0.512													21	101					0	0	0	0	T	73964112	T	T	73964112	3	4	142	1	0	0	0	0	1	0	0	0	8308	710	25	4	4278	4	KIAA2022	23	73964112	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	3817338	73964112	81306448	332	26219											
IL1RAPL2	26280	broad.mit.edu	37	chrX	104984567	104984567	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagagcatcttggagaaaaaGaagttgaattggcactcatc	16	9	10	6	0	2	4	1	1	1	3	3	5	2	4	0	2	1	3	0	2	5	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:104984567G>C	uc004elz.1	+	8	1687	c.931G>C	c.(931-933)GAA>CAA	p.E311Q		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	311	Ig-like C2-type 3.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						TGGAGAAAAAGAAGTTGAATT	0.443													12	61					0	0	0	0	C	104984567	C	C	104984567	3	2	142	1	0	0	0	0	1	0	0	0	7701	943	33	2	957	2	IL1RAPL2	23	104984567	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	31020455	104984567	50285993	333	26220											
TRPC5	7224	broad.mit.edu	37	chrX	111097124	111097124	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggtcaaataggatgctgTgtggcagataaacttgataa	15	10	12	4	0	1	2	1	1	0	1	1	4	1	3	0	3	2	2	0	3	6	4			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:111097124T>A	uc004epl.1	-	4	2030	c.1111A>T	c.(1111-1113)ACA>TCA	p.T371S	TRPC5_uc004epm.1_Missense_Mutation_p.T371S	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	371	Extracellular (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						TAGGATGCTGTGTGGCAGATA	0.498													25	66					0	0	0	0	A	111097124	A	A	111097124	3	1	142	1	0	0	0	0	1	0	0	0	16649	1696	59	5	1842	5	TRPC5	23	111097124	Missense_Mutation	SNP	T	TCGA-CR-7371-01A-11D-2012-08	6112557	111097124	44173436	334	26221											
AMOT	154796	broad.mit.edu	37	chrX	112033890	112033890	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attctcctccaaatatttctGctcccactttgtcatatcag	9	16	3	13	0	4	0	2	0	2	0	7	0	6	0	3	0	1	1	3	0	3	5			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:112033890G>C	uc004epr.2	-	7	2047	c.2047C>G	c.(2047-2049)CAG>GAG	p.Q683E	AMOT_uc004eps.2_Missense_Mutation_p.Q274E	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	683	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						AAATATTTCTGCTCCCACTTT	0.493													39	168					0	0	0	0	C	112033890	C	C	112033890	3	2	142	1	0	0	0	0	1	0	0	0	582	1328	46	4	1227	4	AMOT	23	112033890	Missense_Mutation	SNP	G	TCGA-CR-7371-01A-11D-2012-08	936766	112033890	43236670	335	26222											
GABRQ	55879	broad.mit.edu	37	chrX	151820062	151820062	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccccaacatttcctgtatCaaggccattgatatctatat	11	14	4	12	0	2	1	1	1	1	0	4	1	4	1	4	1	1	1	4	1	6	6			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:151820062C>G	uc004ffp.1	+	8	995	c.975C>G	c.(973-975)ATC>ATG	p.I325M		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	325						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCTGTATCAAGGCCATTG	0.448													33	84					0	0	0	0	G	151820062	G	G	151820062	3	3	142	1	0	0	0	0	1	0	0	0	6209	816	29	2	1005	2	GABRQ	23	151820062	Missense_Mutation	SNP	C	TCGA-CR-7371-01A-11D-2012-08	39786172	151820062	3450498	336	26223											
MAGEA12	4111	broad.mit.edu	37	chrX	151900413	151900413	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcatttctgcctttgtgaAtggctccctggctcgatact	6	14	9	12	1	1	1	0	1	1	0	3	2	2	1	2	2	3	3	2	2	2	3			TCGA-CR-7371-01A-11D-2012-08	TCGA-CR-7371-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	68201be8-a1a9-4c78-ad99-3c767ca8366b	a676c12d-d9aa-4f59-8d74-c0d2684b3631	g.chrX:151900413A>T	uc010ntp.2	-	3	742	c.388T>A	c.(388-390)TTC>ATC	p.F130I	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.F130I|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	130	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GCCTTTGTGAATGGCTCCCTG	0.498													47	117					0	0	0	0	T	151900413	T	T	151900413	3	4	142	1	0	0	0	0	1	0	0	0	9217	101	4	5	560	5	MAGEA12	23	151900413	Missense_Mutation	SNP	A	TCGA-CR-7371-01A-11D-2012-08	80351	151900413	3370147	337	26224											
VSIG8	391123	broad.mit.edu	37	chr1	159827930	159827930	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatggtggtcttcttcaccCggcactcataagtggctgta	7	12	10	12	1	4	0	2	0	2	0	4	0	4	0	2	4	0	3	2	4	2	4			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr1:159827930C>T	uc001fuh.2	-	3	516	c.380G>A	c.(379-381)CGG>CAG	p.R127Q	C1orf204_uc001fug.1_5'Flank	NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	127	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)					CTTCTTCACCCGGCACTCATA	0.562													7	34					0	0	0	0	T	159827930	T	T	159827930	3	4	143	1	0	0	0	0	1	0	0	0	17294	652	23	1	884	1	VSIG8	1	159827930	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08		159827930	89422691	1	26225											
PTPRC	5788	broad.mit.edu	37	chr1	198723447	198723447	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctttgttaaatctcttaGaaagtgcggaaacagaagag	14	11	11	5	1	1	3	0	0	1	3	2	4	1	4	0	1	3	2	0	1	6	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr1:198723447G>T	uc001gur.1	+	32	3733	c.3553G>T	c.(3553-3555)GAA>TAA	p.E1185*	PTPRC_uc001gus.1_Nonsense_Mutation_p.E1137*|PTPRC_uc001gut.1_Nonsense_Mutation_p.E1024*	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1185	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						AAATCTCTTAGAAAGTGCGGA	0.383													13	31					0.00136819	0.00156365	1	0	T	198723447	T	T	198723447	4	4	143	1	0	0	0	0	0	1	0	0	12862	943	33	2	3686	2	PTPRC	1	198723447	Nonsense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08	38895517	198723447	50527174	2	26226											
DISP1	84976	broad.mit.edu	37	chr1	223177009	223177009	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagttccaggtgttccggtCgtcccatccttttgagcgtt	4	14	11	12	4	0	1	0	1	0	0	5	2	4	1	4	2	1	3	4	2	0	5			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr1:223177009C>A	uc001hnu.1	+	8	2417	c.2270C>A	c.(2269-2271)TCG>TAG	p.S757*		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	757					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		GTGTTCCGGTCGTCCCATCCT	0.463													12	67					1.08611e-07	1.39642e-07	1	0	A	223177009	A	A	223177009	4	1	143	1	0	0	0	0	0	1	0	0	4561	893	31	3	2296	3	DISP1	1	223177009	Nonsense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	24453562	223177009	26073612	3	26227											
SFRS7	6432	broad.mit.edu	37	chr2	38976812	38976812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atctccgaggcatgcctgtcGatagttcaaccctcactcgg	8	10	9	14	3	3	0	2	0	1	0	6	2	3	0	3	2	2	2	3	2	2	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr2:38976812G>A	uc002rqz.2	-	3	483	c.245C>T	c.(244-246)TCG>TTG	p.S82L	SFRS7_uc002rra.2_RNA|SFRS7_uc010ynp.1_Missense_Mutation_p.S82L|GEMIN6_uc002rrb.2_5'Flank	NM_001031684	NP_001026854	Q16629	SRSF7_HUMAN	splicing factor, arginine/serine-rich 7	82	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding|zinc ion binding				0		all_hematologic(82;0.248)				CATGCCTGTCGATAGTTCAAC	0.393													19	41					0	0	0	0	A	38976812	A	A	38976812	3	1	143	1	0	0	0	0	1	0	0	0	14247	1059	37	1	495	1	SFRS7	2	38976812	Missense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08		38976812	204222561	4	26228											
BUB1	699	broad.mit.edu	37	chr2	111399701	111399701	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actcaggtcatttacctttaAaacaaatttctgtttatttt	12	19	3	7	0	3	0	2	0	1	0	3	0	3	0	1	1	2	1	1	1	5	9			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr2:111399701A>C	uc002tgc.2	-	20	2570	c.2458T>G	c.(2458-2460)TTA>GTA	p.L820V	BUB1_uc010yxh.1_Missense_Mutation_p.L800V|BUB1_uc010fkb.2_Missense_Mutation_p.L820V	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	820	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TTTACCTTTAAAACAAATTTC	0.353													3	17					0	0	0	0	C	111399701	C	C	111399701	3	2	143	1	0	0	0	0	1	0	0	0	1575	11	1	5	823	5	BUB1	2	111399701	Missense_Mutation	SNP	A	TCGA-CR-7372-01A-11D-2012-08	72422889	111399701	131799672	5	26229											
LRP1B	53353	broad.mit.edu	37	chr2	141081499	141081499	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgatgagatatcaaaacaccTtttgttttatcaatatttaa	15	16	4	6	1	2	1	2	1	0	1	2	3	2	1	1	0	1	1	1	0	7	8			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr2:141081499T>G	uc002tvj.1	-	81	13449	c.12477A>C	c.(12475-12477)AAA>AAC	p.K4159N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4159	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCAAAACACCTTTTGTTTTAT	0.269										TSP Lung(27;0.18)			15	27					0	0	0	0	G	141081499	G	G	141081499	3	3	143	1	0	0	0	0	1	0	0	0	9005	1606	56	5	1366	5	LRP1B	2	141081499	Missense_Mutation	SNP	T	TCGA-CR-7372-01A-11D-2012-08	29681798	141081499	102117874	6	26230											
KIF1A	547	broad.mit.edu	37	chr2	241737138	241737138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaattgaaggggcggaccCgcaccgccaccttcaccgaa	10	4	13	14	4	1	1	1	1	0	0	1	4	1	3	5	4	0	1	5	4	3	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr2:241737138C>T	uc002vzy.2	-	2	178	c.32G>A	c.(31-33)CGG>CAG	p.R11Q	KIF1A_uc010fzk.2_Missense_Mutation_p.R11Q|KIF1A_uc002vzz.1_Missense_Mutation_p.R11Q	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	11	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GGGGCGGACCCGCACCGCCAC	0.602													6	15					0	0	0	0	T	241737138	T	T	241737138	3	4	143	1	0	0	0	0	1	0	0	0	8322	652	23	1	5224	1	KIF1A	2	241737138	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	100655639	241737138	1462235	7	26231											
ALS2CL	259173	broad.mit.edu	37	chr3	46728524	46728524	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagcacgtactgttgcacGtgatgggcgagtggctggtg	7	9	18	7	3	0	1	0	1	0	0	0	3	0	2	0	4	3	5	0	4	1	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr3:46728524G>A	uc003cqa.1	-	5	673	c.483C>T	c.(481-483)CAC>CAT	p.H161H	ALS2CL_uc003cqb.1_Silent_p.H161H|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	161					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		ACTGTTGCACGTGATGGGCGA	0.677													11	15					0	0	0	0	A	46728524	A	A	46728524	2	1	143	1	0	0	0	0	0	0	0	1	551	1136	40	1		1	ALS2CL	3	46728524	Silent	SNP	G	TCGA-CR-7372-01A-11D-2012-08		46728524	151293906	8	26232											
ALCAM	214	broad.mit.edu	37	chr3	105260531	105260531	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacactgacggatgtgaggCgcaatgcaacaggagactac	14	5	12	10	2	0	3	0	2	0	1	0	5	0	4	0	3	3	2	0	3	3	1			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr3:105260531C>T	uc003dvx.2	+	8	1453	c.913C>T	c.(913-915)CGC>TGC	p.R305C	ALCAM_uc003dvw.1_Missense_Mutation_p.R305C|ALCAM_uc003dvy.2_Missense_Mutation_p.R305C|ALCAM_uc011bhh.1_Missense_Mutation_p.R254C|ALCAM_uc010hpp.2_Intron|ALCAM_uc003dvz.2_5'Flank	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	305	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						GGATGTGAGGCGCAATGCAAC	0.423													6	43					0	0	0	0	T	105260531	T	T	105260531	3	4	143	1	0	0	0	0	1	0	0	0	487	768	27	1	943	1	ALCAM	3	105260531	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	58532007	105260531	92761899	9	26233											
GTF2E1	2960	broad.mit.edu	37	chr3	120469828	120469828	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acagacttagaagctaatcaGctctttgatcctatgacagg	13	11	8	9	0	2	4	1	2	1	2	3	4	3	4	1	1	2	2	1	1	4	4			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr3:120469828G>T	uc003edz.3	+	2	543	c.429G>T	c.(427-429)CAG>CAT	p.Q143H	GTF2E1_uc003edy.2_Missense_Mutation_p.Q143H	NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	143	C4-type (Potential).				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		AAGCTAATCAGCTCTTTGATC	0.353													10	45					4.68919e-08	6.13858e-08	1	0	T	120469828	T	T	120469828	3	4	143	1	0	0	0	0	1	0	0	0	6895	962	34	4	431	4	GTF2E1	3	120469828	Missense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08	15209297	120469828	77552602	10	26234											
PLXND1	23129	broad.mit.edu	37	chr3	129284253	129284253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccacagactctgtgcgcCgcagcatgagcttggggttc	7	8	12	14	2	1	2	0	1	1	1	2	2	1	2	3	2	3	4	3	2	0	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr3:129284253C>T	uc003emx.2	-	25	4551	c.4451G>A	c.(4450-4452)CGG>CAG	p.R1484Q	PLXND1_uc011blb.1_Missense_Mutation_p.R152Q	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1484	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CTCTGTGCGCCGCAGCATGAG	0.602													14	103					0	0	0	0	T	129284253	T	T	129284253	3	4	143	1	0	0	0	0	1	0	0	0	12182	652	23	1	1374	1	PLXND1	3	129284253	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	8814425	129284253	68738177	11	26235											
CAMK2D	817	broad.mit.edu	37	chr4	114469879	114469879	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttctagaatctgctgtatAcaatgactgcaaagatacaa	15	12	6	8	0	2	3	0	1	2	2	2	3	2	3	0	0	4	3	0	0	8	5			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr4:114469879A>G	uc003ibi.2	-	6	1207	c.348T>C	c.(346-348)TGT>TGC	p.C116C	CAMK2D_uc003ibj.2_Silent_p.C116C|CAMK2D_uc003ibk.2_Silent_p.C116C|CAMK2D_uc003ibo.3_Intron|CAMK2D_uc003ibm.2_Silent_p.C116C|CAMK2D_uc003ibn.2_Silent_p.C116C|CAMK2D_uc003ibl.2_Silent_p.C116C	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	116	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		TCTGCTGTATACAATGACTGC	0.358													6	14					0	0	0	0	G	114469879	G	G	114469879	2	3	143	1	0	0	0	0	0	0	0	1	2613	389	14	5		5	CAMK2D	4	114469879	Silent	SNP	A	TCGA-CR-7372-01A-11D-2012-08		114469879	76684397	12	26236											
CDC23	8697	broad.mit.edu	37	chr5	137548688	137548688	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatgtccttacctctgtaaTaggcggaggcggttgcagct	8	11	12	10	2	1	0	0	0	1	0	2	1	2	1	2	4	3	4	2	4	3	4			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr5:137548688T>A	uc003lcl.2	-	2	257	c.226A>T	c.(226-228)ATT>TTT	p.I76F	CDC23_uc003lcm.1_Missense_Mutation_p.I76F	NM_004661	NP_004652	Q9UJX2	CDC23_HUMAN	cell division cycle protein 23	76					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ACCTCTGTAATAGGCGGAGGC	0.438													13	81					0	0	0	0	A	137548688	A	A	137548688	3	1	143	1	0	0	0	0	1	0	0	0	3076	1406	49	5	1627	5	CDC23	5	137548688	Missense_Mutation	SNP	T	TCGA-CR-7372-01A-11D-2012-08		137548688	43366572	13	26237											
HIST1H1E	3008	broad.mit.edu	37	chr6	26156805	26156807	+	In_Frame_Del	DEL	AAG	-	-																															gcgtatctttggccgctctcAagaaagcgctggcagccgct																										TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr6:26156805_26156807delAAG	uc003ngq.2	+	1	247_249	c.187_189delAAG	c.(187-189)AAGdel	p.K64del	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	64	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						GGCCGCTCTCAAGAAAGCGCTGG	0.616													---	---	---								-	26156807	-	-	26156805	7	5	143	1	0	1	0	1	0	0	0	0	7165	131	5	0	189	0	HIST1H1E	6	26156805	In_Frame_Del	DEL	AAG	TCGA-CR-7372-01A-11D-2012-08		26156805	144958262	14	26238											
MTO1	25821	broad.mit.edu	37	chr6	74176036	74176037	+	Frame_Shift_Ins	INS	-	GT	GT																															tcgcatctgtgaccagtctgINSgtgtacattataaagtatta																										TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr6:74176036_74176037insGT	uc003pgy.3	+	2	446_447	c.322_323insGT	c.(322-324)GGTfs	p.G108fs	MTO1_uc010kav.2_Frame_Shift_Ins_p.G108fs|MTO1_uc003pgz.3_Frame_Shift_Ins_p.G108fs|MTO1_uc003pha.3_5'UTR|MTO1_uc003phb.3_Frame_Shift_Ins_p.G34fs|MTO1_uc003phc.1_Frame_Shift_Ins_p.G34fs	NM_133645	NP_598400	Q9Y2Z2	MTO1_HUMAN	mitochondrial translation optimization 1 homolog	108					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			ovary(3)|skin(2)|pancreas(1)	6						TGACCAGTCTGGTGTACATTAT	0.455													---	---	---								GT	74176037	GT	GT	74176036	7	5	143	1	0	1	1	0	0	0	0	0	10006	1348	47	0	328	0	MTO1	6	74176036	Frame_Shift_Ins	INS	-	TCGA-CR-7372-01A-11D-2012-08	48019231	74176036	96939031	15	26239											
HS3ST5	222537	broad.mit.edu	37	chr6	114379098	114379098	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attatcaaaaaagtggatttCttgagaggctttgactactg	13	14	9	5	0	2	2	1	2	1	1	2	4	2	3	0	2	1	1	0	2	5	5			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr6:114379098C>A	uc003pwg.3	-	2	396	c.364G>T	c.(364-366)GAA>TAA	p.E122*	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Nonsense_Mutation_p.E122*	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	122	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		AAGTGGATTTCTTGAGAGGCT	0.443													16	72					1.3612e-06	1.63344e-06	1	0	A	114379098	A	A	114379098	4	1	143	1	0	0	0	0	0	1	0	0	7407	922	32	2	680	2	HS3ST5	6	114379098	Nonsense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	40203062	114379098	56735969	16	26240											
PRKAR1B	5575	broad.mit.edu	37	chr7	635848	635848	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtccgtcttggctttcaCggtcgcagccctgggggtgc	3	10	16	12	3	2	0	1	0	1	0	4	1	3	0	2	5	2	2	2	5	0	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr7:635848C>T	uc003siu.1	-	8	749	c.643G>A	c.(643-645)GTG>ATG	p.V215M	PRKAR1B_uc003siv.2_Missense_Mutation_p.V215M|PRKAR1B_uc003siw.1_Missense_Mutation_p.V215M|PRKAR1B_uc003six.1_RNA	NM_002735	NP_002726	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type	215	cAMP 1.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		TTGGCTTTCACGGTCGCAGCC	0.622													19	63					0	0	0	0	T	635848	T	T	635848	3	4	143	1	0	0	0	0	1	0	0	0	12566	536	19	1	522	1	PRKAR1B	7	635848	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08		635848	158502815	17	26241											
TNRC18	84629	broad.mit.edu	37	chr7	5410483	5410484	+	Missense_Mutation	DNP	GC	TT	TT																															cagtgtctcgggtgtcagctGcacccccaggtccagggcgg																										TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr7:5410483_5410484GC>TT	uc003soi.3	-	11	4090_4091	c.3741_3742GC>AA	c.(3739-3744)GTGCAG>GTAAAG	p.Q1248K		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1248							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GGTGTCAGCTGCACCCCCAGGT	0.693													11	31					0	0	0	0	TT	5410484	TT	TT	5410483	3	4	143	1	0	0	0	0	1	0	0	0	16405	1328	46	4	5244	4	TNRC18	7	5410483	Missense_Mutation	DNP	GC	TCGA-CR-7372-01A-11D-2012-08	4774635	5410483	153728180	18	26242											
OGDH	4967	broad.mit.edu	37	chr7	44737087	44737087	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acagctcactgtctgagtacGgcgtgctgggtgagtgcctg	6	10	15	10	2	2	2	1	2	1	0	2	2	2	2	1	2	4	3	1	2	1	1			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr7:44737087G>A	uc003tln.2	+	16	2279	c.2170G>A	c.(2170-2172)GGC>AGC	p.G724S	OGDH_uc011kbx.1_Missense_Mutation_p.G720S|OGDH_uc011kby.1_Missense_Mutation_p.G574S|OGDH_uc003tlp.2_Missense_Mutation_p.G735S|OGDH_uc011kbz.1_Missense_Mutation_p.G519S|OGDH_uc003tlo.1_Missense_Mutation_p.G557S	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	724					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GTCTGAGTACGGCGTGCTGGG	0.597													12	74					0	0	0	0	A	44737087	A	A	44737087	3	1	143	1	0	0	0	0	1	0	0	0	10893	1116	39	1	2401	1	OGDH	7	44737087	Missense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08	39326604	44737087	114401576	19	26243											
STEAP4	79689	broad.mit.edu	37	chr7	87913465	87913465	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacaacagaataaccacaCtggagcattttcaatcccag	18	7	5	11	0	1	1	1	0	0	1	2	2	2	2	2	1	4	1	2	1	6	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr7:87913465C>A	uc003ujs.2	-	2	225	c.120G>T	c.(118-120)CAG>CAT	p.Q40H	STEAP4_uc010lek.2_Missense_Mutation_p.Q40H|STEAP4_uc003ujt.2_Missense_Mutation_p.Q40H	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	40					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					AATAACCACACTGGAGCATTT	0.428													9	58					7.48243e-07	9.1311e-07	1	0	A	87913465	A	A	87913465	3	1	143	1	0	0	0	0	1	0	0	0	15346	564	20	4	1275	4	STEAP4	7	87913465	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	43176378	87913465	71225198	20	26244											
PTPRZ1	5803	broad.mit.edu	37	chr7	121691548	121691548	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taaagcaatgcaacagggaaAagaatcgaacttcttctatc	17	9	7	8	1	2	1	0	0	2	1	4	3	2	2	0	1	4	2	0	1	9	4			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr7:121691548A>T	uc003vjy.2	+	24	6546	c.6151A>T	c.(6151-6153)AAG>TAG	p.K2051*	PTPRZ1_uc003vjz.2_Nonsense_Mutation_p.K1184*|PTPRZ1_uc011knt.1_Nonsense_Mutation_p.K641*	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	2051	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CAACAGGGAAAAGAATCGAAC	0.348													28	60					0	0	0	0	T	121691548	T	T	121691548	4	4	143	1	0	0	0	0	0	1	0	0	12879	15	1	5	6245	5	PTPRZ1	7	121691548	Nonsense_Mutation	SNP	A	TCGA-CR-7372-01A-11D-2012-08	33778083	121691548	37447115	21	26245											
ZFHX4	79776	broad.mit.edu	37	chr8	77690483	77690483	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcagtgaatcccgaatccTgctattactactgtgccgtg	8	12	10	11	2	0	1	0	1	0	0	2	2	2	1	3	0	5	2	3	0	5	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr8:77690483T>C	uc003yav.2	+	4	3442	c.3055T>C	c.(3055-3057)TGC>CGC	p.C1019R	ZFHX4_uc003yau.1_Missense_Mutation_p.C1045R|ZFHX4_uc003yaw.1_Missense_Mutation_p.C1019R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1019						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCCCGAATCCTGCTATTACTA	0.488										HNSCC(33;0.089)			21	151					0	0	0	0	C	77690483	C	C	77690483	3	2	143	1	0	0	0	0	1	0	0	0	17702	1580	55	5	3143	5	ZFHX4	8	77690483	Missense_Mutation	SNP	T	TCGA-CR-7372-01A-11D-2012-08		77690483	68673539	22	26246											
PKHD1L1	93035	broad.mit.edu	37	chr8	110477209	110477209	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcggccatcttgatgaactGggaatggggtctgcattttg	7	13	14	7	1	2	2	0	2	2	0	3	3	2	3	1	4	2	1	1	4	2	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr8:110477209G>T	uc003yne.2	+	49	8252	c.8148G>T	c.(8146-8148)CTG>CTT	p.L2716L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2716	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTGATGAACTGGGAATGGGGT	0.473										HNSCC(38;0.096)			44	113					8.20599e-20	1.15849e-19	1	0	T	110477209	T	T	110477209	2	4	143	1	0	0	0	0	0	0	0	1	12027	1335	47	4		4	PKHD1L1	8	110477209	Silent	SNP	G	TCGA-CR-7372-01A-11D-2012-08	32786726	110477209	35886813	23	26247											
CSMD3	114788	broad.mit.edu	37	chr8	113649178	113649178	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accaatcccaaagttgaaccCgattcgactaccatattgag	14	9	6	12	2	0	2	0	2	0	0	2	4	1	2	4	0	2	1	4	0	5	5			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr8:113649178C>T	uc003ynu.2	-	22	3742	c.3583G>A	c.(3583-3585)GGG>AGG	p.G1195R	CSMD3_uc003yns.2_Missense_Mutation_p.G467R|CSMD3_uc003ynt.2_Missense_Mutation_p.G1155R|CSMD3_uc011lhx.1_Missense_Mutation_p.G1091R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1195	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAGTTGAACCCGATTCGACTA	0.473										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	60					0	0	0	0	T	113649178	T	T	113649178	3	4	143	1	0	0	0	0	1	0	0	0	3963	652	23	1	7740	1	CSMD3	8	113649178	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	3171969	113649178	32714844	24	26248											
KCNK9	51305	broad.mit.edu	37	chr8	140630972	140630972	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagctaaaggccacgtagagCggcttcttctgcagggcacc	10	7	12	12	2	2	1	0	0	2	1	2	1	2	1	2	3	3	5	2	3	4	4			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr8:140630972C>T	uc003yvf.1	-	2	718	c.654G>A	c.(652-654)CCG>CCA	p.P218P	KCNK9_uc003yvg.1_Silent_p.P218P|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	218	Extracellular (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CCACGTAGAGCGGCTTCTTCT	0.557													20	99					0	0	0	0	T	140630972	T	T	140630972	2	4	143	1	0	0	0	0	0	0	0	1	8111	755	27	1		1	KCNK9	8	140630972	Silent	SNP	C	TCGA-CR-7372-01A-11D-2012-08	26981794	140630972	5733050	25	26249											
PTPN3	5774	broad.mit.edu	37	chr9	112200446	112200446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taaaaagtcctcattttgatCgggtataaagtgactatcgg	13	13	9	6	2	1	2	1	2	0	0	4	2	2	2	1	2	0	1	1	2	7	6			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr9:112200446C>T	uc004bed.2	-	8	647	c.535G>A	c.(535-537)GAT>AAT	p.D179N	PTPN3_uc004beb.2_Missense_Mutation_p.D48N|PTPN3_uc004bec.2_Missense_Mutation_p.D48N|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.D179N|PTPN3_uc011lwh.1_Missense_Mutation_p.D70N	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	179	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						TCATTTTGATCGGGTATAAAG	0.433													13	49					0	0	0	0	T	112200446	T	T	112200446	3	4	143	1	0	0	0	0	1	0	0	0	12854	884	31	1	2282	1	PTPN3	9	112200446	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08		112200446	29012985	26	26250											
TTLL11	158135	broad.mit.edu	37	chr9	124751527	124751527	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtctgactggtagaagaCtttgagctctggagtcagcg	9	11	14	7	1	3	4	1	2	2	2	3	6	3	5	0	2	2	2	0	2	2	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr9:124751527C>T	uc004blt.1	-	4	1674	c.1486G>A	c.(1486-1488)GTC>ATC	p.V496I	TTLL11_uc011lyl.1_Missense_Mutation_p.V496I|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Missense_Mutation_p.V173I|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	496	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						TGGTAGAAGACTTTGAGCTCT	0.562													14	77					0	0	0	0	T	124751527	T	T	124751527	3	4	143	1	0	0	0	0	1	0	0	0	16792	565	20	4	1018	4	TTLL11	9	124751527	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	12551081	124751527	16461904	27	26251											
KIAA1217	56243	broad.mit.edu	37	chr10	24834796	24834796	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctggtggggactttaagcCtacttccccctccttacctg	6	13	8	14	0	1	0	0	0	1	0	3	1	3	1	5	3	3	0	5	3	3	5			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr10:24834796C>T	uc001iru.3	+	21	5778	c.5375C>T	c.(5374-5376)CCT>CTT	p.P1792L	KIAA1217_uc001irs.2_Missense_Mutation_p.P1113L|KIAA1217_uc001irt.3_Missense_Mutation_p.P1158L|KIAA1217_uc010qcy.1_Missense_Mutation_p.P1223L|KIAA1217_uc010qcz.1_Missense_Mutation_p.P1198L|KIAA1217_uc001irw.2_3'UTR|KIAA1217_uc001irz.2_3'UTR|KIAA1217_uc001irx.2_3'UTR|KIAA1217_uc001iry.2_3'UTR	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1792					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GACTTTAAGCCTACTTCCCCC	0.493													14	107					0	0	0	0	T	24834796	T	T	24834796	3	4	143	1	0	0	0	0	1	0	0	0	8255	681	24	4	5457	4	KIAA1217	10	24834796	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08		24834796	110699951	28	26252											
TDRD1	56165	broad.mit.edu	37	chr10	115962045	115962045	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgaaacaaaggatgtggaGgtaaacaataaggtatggta	18	9	12	2	0	0	1	0	1	0	0	0	3	0	3	0	5	2	3	0	5	8	5			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr10:115962045G>A	uc001lbg.1	+	6	837	c.684G>A	c.(682-684)GAG>GAA	p.E228E	TDRD1_uc001lbf.2_Silent_p.E219E|TDRD1_uc001lbh.1_Silent_p.E219E|TDRD1_uc001lbi.1_Silent_p.E219E|TDRD1_uc010qsc.1_5'Flank|TDRD1_uc001lbj.2_5'Flank	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	228					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		AGGATGTGGAGGTAAACAATA	0.264													11	21					0	0	0	0	A	115962045	A	A	115962045	2	1	143	1	0	0	0	0	0	0	0	1	15796	991	35	4		4	TDRD1	10	115962045	Silent	SNP	G	TCGA-CR-7372-01A-11D-2012-08	91127249	115962045	19572702	29	26253											
IPO7	10527	broad.mit.edu	37	chr11	9445348	9445348	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttatccaagatgttatttttCcattgatgtgctatacagat	11	18	6	6	0	0	3	0	1	0	2	2	3	2	3	2	0	2	2	2	0	5	7			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr11:9445348C>A	uc001mho.2	+	10	1208	c.1066C>A	c.(1066-1068)CCA>ACA	p.P356T		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	356					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TGTTATTTTTCCATTGATGTG	0.308													13	45					4.3838e-07	5.44196e-07	1	0	A	9445348	A	A	9445348	3	1	143	1	0	0	0	0	1	0	0	0	7836	855	30	2	1104	2	IPO7	11	9445348	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08		9445348	125561168	30	26254											
OR5M8	219484	broad.mit.edu	37	chr11	56258616	56258616	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatctccagcatctttggAgtcacattggaagagaagca	15	9	9	8	0	3	1	1	0	2	1	4	4	3	3	1	2	2	2	1	2	4	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr11:56258616A>G	uc001nix.1	-	1	231	c.231T>C	c.(229-231)ACT>ACC	p.T77T		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	77	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					GCATCTTTGGAGTCACATTGG	0.468													8	89					0	0	0	0	G	56258616	G	G	56258616	2	3	143	1	0	0	0	0	0	0	0	1	11230	291	11	5		5	OR5M8	11	56258616	Silent	SNP	A	TCGA-CR-7372-01A-11D-2012-08	46813268	56258616	78747900	31	26255			1	38		2	2	30	N	C_A	5.339566e-05
OR5M8	219484	broad.mit.edu	37	chr11	56258645	56258645	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagagaagcacagatccaCgaaggataagtggctcagga	16	4	14	7	1	1	2	1	0	0	2	2	7	2	5	1	4	1	2	1	4	4	1			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr11:56258645C>G	uc001nix.1	-	1	202	c.202G>C	c.(202-204)GTG>CTG	p.V68L		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					CACAGATCCACGAAGGATAAG	0.493													8	100					0	0	0	0	G	56258645	G	G	56258645	3	3	143	1	0	0	0	0	1	0	0	0	11230	536	19	3	737	3	OR5M8	11	56258645	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	29	56258645	78747871	32	26256			1	38		2	2	30	N	C_A	5.339566e-05
PRB4	5545	broad.mit.edu	37	chr12	11461743	11461743	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctccttgtgggggtggtccTtgtggctttcctggaggagg	2	13	17	9	0	0	0	0	0	0	0	3	2	3	2	4	7	0	1	4	7	0	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr12:11461743T>C	uc001qzf.1	-	3	208	c.174A>G	c.(172-174)CAA>CAG	p.Q58Q	PRB4_uc001qzt.2_Silent_p.Q58Q	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	58	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|2.					extracellular region				ovary(1)	1						GGGGTGGTCCTTGTGGCTTTC	0.622										HNSCC(22;0.051)			94	290					0	0	0	0	C	11461743	C	C	11461743	2	2	143	1	0	0	0	0	0	0	0	1	12507	1606	56	5		5	PRB4	12	11461743	Silent	SNP	T	TCGA-CR-7372-01A-11D-2012-08		11461743	122390152	33	26257											
GRIP1	23426	broad.mit.edu	37	chr12	66786267	66786267	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatagggaacttcttggggCtcgatgctgactgggcttta	9	12	13	7	1	1	1	0	1	1	0	2	3	1	2	0	4	2	3	0	4	4	5			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr12:66786267C>A	uc001stk.2	-	18	2370	c.2129G>T	c.(2128-2130)AGC>ATC	p.S710I	GRIP1_uc010sta.1_Missense_Mutation_p.S654I|GRIP1_uc001stj.2_Missense_Mutation_p.S492I|GRIP1_uc001stl.1_Missense_Mutation_p.S602I|GRIP1_uc001stm.2_Missense_Mutation_p.S710I	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	762					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CTTCTTGGGGCTCGATGCTGA	0.453													13	99					9.31168e-06	1.09908e-05	1	0	A	66786267	A	A	66786267	3	1	143	1	0	0	0	0	1	0	0	0	6826	797	28	4	1129	4	GRIP1	12	66786267	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	55324524	66786267	67065628	34	26258											
POLE	5426	broad.mit.edu	37	chr12	133215740	133215740	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcttcttcatcatgttgtgGagtgtgcggtgcagggcagg	6	12	16	7	1	3	0	2	0	1	0	3	1	3	1	0	4	3	4	0	4	0	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr12:133215740G>A	uc001uks.1	-	40	5567	c.5523C>T	c.(5521-5523)CTC>CTT	p.L1841L	POLE_uc001ukq.1_Silent_p.L51L|POLE_uc001ukr.1_Silent_p.L645L|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1841					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TCATGTTGTGGAGTGTGCGGT	0.582								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage			OREG0022269	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	35					0	0	0	0	A	133215740	A	A	133215740	2	1	143	1	0	0	0	0	0	0	0	1	12251	1161	41	2		2	POLE	12	133215740	Silent	SNP	G	TCGA-CR-7372-01A-11D-2012-08	66429473	133215740	636155	35	26259											
DIAPH3	81624	broad.mit.edu	37	chr13	60384961	60384961	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acgctttttcttttgttggcGttcgagtctttctcgctctg	2	20	9	10	4	4	0	0	0	4	0	6	1	4	0	0	1	0	4	0	1	0	7			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr13:60384961G>A	uc001vht.2	-	25	3343	c.3124C>T	c.(3124-3126)CGC>TGC	p.R1042C	DIAPH3_uc001vhu.2_Missense_Mutation_p.R779C	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	1042	Potential.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TTTTGTTGGCGTTCGAGTCTT	0.323													3	33					0	0	0	0	A	60384961	A	A	60384961	3	1	143	1	0	0	0	0	1	0	0	0	4542	1145	40	1	493	1	DIAPH3	13	60384961	Missense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08		60384961	54784917	36	26260											
NALCN	259232	broad.mit.edu	37	chr13	101714441	101714441	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccagctgcaagctcttcCggatgtccacggaccggtat	7	9	10	15	3	1	0	0	0	1	0	4	2	4	2	5	3	3	4	5	3	2	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr13:101714441C>T	uc001vox.1	-	41	4823	c.4634G>A	c.(4633-4635)CGG>CAG	p.R1545Q		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1545	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity	p.R1545W(1)		ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CAAGCTCTTCCGGATGTCCAC	0.542													13	43					0	0	0	0	T	101714441	T	T	101714441	3	4	143	1	0	0	0	0	1	0	0	0	10201	652	23	1	598	1	NALCN	13	101714441	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	41329480	101714441	13455437	37	26261											
TP53BP1	7158	broad.mit.edu	37	chr15	43705366	43705366	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccatctggcagtttggagcgGctggccaacttgtcactggt	6	11	13	11	1	2	0	1	0	1	0	2	1	2	1	2	5	2	3	2	5	1	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr15:43705366G>A	uc001zrs.2	-	24	5389	c.5241C>T	c.(5239-5241)AGC>AGT	p.S1747S	TP53BP1_uc010udp.1_Silent_p.S1745S|TP53BP1_uc001zrq.3_Silent_p.S1750S|TP53BP1_uc001zrr.3_Silent_p.S1752S|TP53BP1_uc001zrp.2_Silent_p.S164S	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1747	BRCT 1.				double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GTTTGGAGCGGCTGGCCAACT	0.537								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					3	64					0	0	0	0	A	43705366	A	A	43705366	2	1	143	1	0	0	0	0	0	0	0	1	16450	1194	42	4		4	TP53BP1	15	43705366	Silent	SNP	G	TCGA-CR-7372-01A-11D-2012-08		43705366	58826026	38	26262											
MAP1A	4130	broad.mit.edu	37	chr15	43815758	43815758	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaggtaactccaaggagccGggaggcttttgggggtcggg	8	7	19	7	2	0	0	0	0	0	0	2	3	1	2	2	7	2	2	2	7	3	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr15:43815758G>T	uc001zrt.2	+	4	2554	c.2087G>T	c.(2086-2088)CGG>CTG	p.R696L		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	696						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCAAGGAGCCGGGAGGCTTTT	0.547													7	24					8.12818e-05	9.43918e-05	1	0	T	43815758	T	T	43815758	3	4	143	1	0	0	0	0	1	0	0	0	9280	1116	39	3	2089	3	MAP1A	15	43815758	Missense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08	110392	43815758	58715634	39	26263											
DUOX1	53905	broad.mit.edu	37	chr15	45439652	45439652	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctggacatcaaccaggccGacgcagggaccctgcccctg	8	5	12	16	2	1	0	1	0	0	0	1	3	1	2	5	3	3	2	5	3	1	0			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr15:45439652G>A	uc001zus.1	+	20	2690	c.2344G>A	c.(2344-2346)GAC>AAC	p.D782N	DUOX1_uc001zut.1_Missense_Mutation_p.D782N|DUOX1_uc010bee.1_Missense_Mutation_p.D162N|DUOX1_uc001zuu.2_5'Flank	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	782	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CAACCAGGCCGACGCAGGGAC	0.637													3	19					0	0	0	0	A	45439652	A	A	45439652	3	1	143	1	0	0	0	0	1	0	0	0	4822	1058	37	1	2414	1	DUOX1	15	45439652	Missense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08	1623894	45439652	57091740	40	26264											
UNC13C	440279	broad.mit.edu	37	chr15	54542506	54542506	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacaattttgaggtctggacGgctaccacacccacctactg	10	9	8	14	1	1	1	0	1	1	0	1	2	1	2	3	3	2	1	3	3	3	4			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr15:54542506G>A	uc002ack.2	+	6	3312	c.3312G>A	c.(3310-3312)ACG>ACA	p.T1104T		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1104	Phorbol-ester/DAG-type.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGGTCTGGACGGCTACCACAC	0.493													17	37					0	0	0	0	A	54542506	A	A	54542506	2	1	143	1	0	0	0	0	0	0	0	1	17054	1103	39	1		1	UNC13C	15	54542506	Silent	SNP	G	TCGA-CR-7372-01A-11D-2012-08	9102854	54542506	47988886	41	26265											
POLG	5428	broad.mit.edu	37	chr15	89871966	89871966	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccttcacaaacagttctcGaggctccttctctaagggag	9	10	9	13	1	3	0	1	0	2	0	6	2	4	1	2	2	1	2	2	2	2	4			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr15:89871966G>A	uc002bns.3	-	5	1402	c.1120C>T	c.(1120-1122)CGA>TGA	p.R374*	POLG_uc002bnr.3_Nonsense_Mutation_p.R374*	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	374					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			AACAGTTCTCGAGGCTCCTTC	0.567								DNA_polymerases_(catalytic_subunits)					8	187					0	0	0	0	A	89871966	A	A	89871966	4	1	143	1	0	0	0	0	0	1	0	0	12255	1066	37	1	2675	1	POLG	15	89871966	Nonsense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08	35329460	89871966	12659426	42	26266											
SEC14L5	9717	broad.mit.edu	37	chr16	5058627	5058627	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggaggctccccttgtctGccgggagggggagagcatcc	5	8	17	11	1	1	1	0	0	1	1	3	4	3	3	4	5	2	2	4	5	0	1			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr16:5058627G>T	uc002cye.2	+	14	1958	c.1778G>T	c.(1777-1779)TGC>TTC	p.C593F		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	593	GOLD.					integral to membrane|intracellular	transporter activity				0						CCCCTTGTCTGCCGGGAGGGG	0.468													22	83					1.96895e-08	2.62526e-08	1	0	T	5058627	T	T	5058627	3	4	143	1	0	0	0	0	1	0	0	0	14050	1319	46	4	1828	4	SEC14L5	16	5058627	Missense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08		5058627	85296126	43	26267											
CNOT1	23019	broad.mit.edu	37	chr16	58633241	58633241	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgagagcgagtcaagattcaTtgctggttggggcggaagca	10	8	16	7	3	2	2	2	0	0	2	2	5	2	3	0	4	3	3	0	4	2	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr16:58633241T>C	uc002env.2	-	2	294	c.1A>G	c.(1-3)ATG>GTG	p.M1V	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.M1V|CNOT1_uc002enx.2_Missense_Mutation_p.M1V|CNOT1_uc002enz.1_5'UTR	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TCAAGATTCATTGCTGGTTGG	0.498													20	56					0	0	0	0	C	58633241	C	C	58633241	3	2	143	1	0	0	0	0	1	0	0	0	3632	1493	52	5	7543	5	CNOT1	16	58633241	Missense_Mutation	SNP	T	TCGA-CR-7372-01A-11D-2012-08	53574614	58633241	31721512	44	26268											
AP1G1	164	broad.mit.edu	37	chr16	71784153	71784153	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctttgtacaggcgctggAcagtataggcatgcatctcc	8	12	11	10	1	1	0	0	0	1	0	2	1	1	1	1	3	3	6	1	3	3	5			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr16:71784153A>G	uc010cgg.2	-	14	1681	c.1367T>C	c.(1366-1368)GTC>GCC	p.V456A	AP1G1_uc002fba.2_Missense_Mutation_p.V459A|AP1G1_uc002fbb.2_Missense_Mutation_p.V479A|AP1G1_uc002faz.2_5'Flank	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	456					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				CAGGCGCTGGACAGTATAGGC	0.378													19	157					0	0	0	0	G	71784153	G	G	71784153	3	3	143	1	0	0	0	0	1	0	0	0	732	275	10	5	1141	5	AP1G1	16	71784153	Missense_Mutation	SNP	A	TCGA-CR-7372-01A-11D-2012-08	13150912	71784153	18570600	45	26269											
TP53	7157	broad.mit.edu	37	chr17	7579450	7579451	+	Frame_Shift_Ins	INS	-	G	G																															caggggccgccggtgtaggaINSgctgctggtgcaggggccac																										TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr17:7579450_7579451insG	uc002gim.2	-	4	430_431	c.236_237insC	c.(235-237)GCTfs	p.A79fs	TP53_uc002gig.1_Frame_Shift_Ins_p.A79fs|TP53_uc002gih.2_Frame_Shift_Ins_p.A79fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Ins_p.A79fs|TP53_uc010cni.1_Frame_Shift_Ins_p.A79fs|TP53_uc002gij.2_Frame_Shift_Ins_p.A79fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Ins_p.A40fs|TP53_uc010cnk.1_Frame_Shift_Ins_p.A94fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	79	Interaction with WWOX.|Interaction with HRMT1L2.		A -> G (in a sporadic cancer; somatic mutation).|A -> T (in a sporadic cancer; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.A76_S90del15(3)|p.G59fs*23(3)|p.V73fs*9(1)|p.R65fs*38(1)|p.D48fs*55(1)|p.A79V(1)|p.A79_A88del10(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTGTAGGAGCTGCTGGTGC	0.624		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								G	7579451	G	G	7579450	7	5	143	1	0	1	1	0	0	0	0	0	16448	291	11	0	1065	0	TP53	17	7579450	Frame_Shift_Ins	INS	-	TCGA-CR-7372-01A-11D-2012-08		7579450	73615760	46	26270											
DSC2	1824	broad.mit.edu	37	chr18	28651727	28651727	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagtgacactagacatgcCaagtctatctctcactgtta	12	12	7	10	0	3	3	1	2	2	1	4	3	3	3	1	0	1	1	1	0	5	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr18:28651727C>T	uc002kwl.3	-	13	2423	c.1969G>A	c.(1969-1971)GGC>AGC	p.G657S	DSC2_uc002kwk.3_Missense_Mutation_p.G657S	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	657	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CTAGACATGCCAAGTCTATCT	0.408													9	16					0	0	0	0	T	28651727	T	T	28651727	3	4	143	1	0	0	0	0	1	0	0	0	4788	594	21	4	792	4	DSC2	18	28651727	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08		28651727	49425521	47	26271											
DTNA	1837	broad.mit.edu	37	chr18	32443990	32443990	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caggagagccggagagagctAatggtccagttggagggtct	10	7	17	7	1	1	2	0	0	1	2	2	6	2	4	2	5	2	2	2	5	1	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr18:32443990A>G	uc010dmn.1	+	16	1627	c.1626A>G	c.(1624-1626)CTA>CTG	p.L542L	DTNA_uc010xbx.1_Silent_p.L292L|DTNA_uc002kxv.3_Silent_p.L485L|DTNA_uc002kxw.2_Silent_p.L485L|DTNA_uc010dmj.2_Silent_p.L482L|DTNA_uc002kxz.2_Silent_p.L482L|DTNA_uc002kxy.2_Silent_p.L482L|DTNA_uc010dml.2_Silent_p.L482L|DTNA_uc002kyb.3_Silent_p.L539L|DTNA_uc010dmm.2_Silent_p.L542L|DTNA_uc010xby.1_Silent_p.L232L|DTNA_uc010dmo.2_Silent_p.*163*|DTNA_uc002kyd.3_Silent_p.L164L|DTNA_uc010xbz.1_Silent_p.L251L|DTNA_uc010xca.1_Silent_p.L194L|DTNA_uc002kye.2_Silent_p.L190L	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	542	Potential.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						GGAGAGAGCTAATGGTCCAGT	0.458													7	8					0	0	0	0	G	32443990	G	G	32443990	2	3	143	1	0	0	0	0	0	0	0	1	4810	349	13	5		5	DTNA	18	32443990	Silent	SNP	A	TCGA-CR-7372-01A-11D-2012-08	3792263	32443990	45633258	48	26272											
ATP8B3	148229	broad.mit.edu	37	chr19	1784856	1784856	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagggctgggaagatgactcGgagggccaggacagggaagg	11	3	21	6	1	0	2	0	1	0	1	1	7	0	6	1	7	0	1	1	7	2	0			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:1784856G>A	uc002ltw.2	-	28	3856	c.3622C>T	c.(3622-3624)CGA>TGA	p.R1208*	ATP8B3_uc002ltv.2_Nonsense_Mutation_p.R1171*|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1208	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGATGACTCGGAGGGCCAGG	0.622													3	23					0	0	0	0	A	1784856	A	A	1784856	4	1	143	1	0	0	0	0	0	1	0	0	1198	1124	39	1	288	1	ATP8B3	19	1784856	Nonsense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08		1784856	57344127	49	26273											
ZNF792	126375	broad.mit.edu	37	chr19	35450296	35450296	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cacaaatggtttctgcctggGatgtgttgtctggtgttcag	6	15	13	7	0	3	0	1	0	2	0	3	1	3	1	1	3	1	3	1	3	1	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:35450296G>T	uc002nxh.1	-	4	850	c.463C>A	c.(463-465)CCC>ACC	p.P155T		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TTCTGCCTGGGATGTGTTGTC	0.507													76	112					3.00167e-28	4.32241e-28	1	0	T	35450296	T	T	35450296	3	4	143	1	0	0	0	0	1	0	0	0	18231	1174	41	2	1439	2	ZNF792	19	35450296	Missense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08	33665440	35450296	23678687	50	26274											
CLIP3	25999	broad.mit.edu	37	chr19	36515479	36515479	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccgcctctgccttgtccAgggacatgtccataggatct	6	11	11	13	1	2	0	0	0	2	0	4	2	4	2	5	2	2	0	5	2	1	2			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:36515479A>G	uc010eeq.1	-	6	1019	c.737T>C	c.(736-738)CTG>CCG	p.L246P	uc002ocy.2_Intron|CLIP3_uc002ocz.1_Missense_Mutation_p.L246P	NM_015526	NP_056341	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	246					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TGCCTTGTCCAGGGACATGTC	0.612													3	59					0	0	0	0	G	36515479	G	G	36515479	3	3	143	1	0	0	0	0	1	0	0	0	3549	188	7	5	938	5	CLIP3	19	36515479	Missense_Mutation	SNP	A	TCGA-CR-7372-01A-11D-2012-08	1065183	36515479	22613504	51	26275											
CIC	23152	broad.mit.edu	37	chr19	42793503	42793503	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcggccagtgaggacatgacGagtgatgaggagcgcatggt	10	6	18	7	3	0	4	0	4	0	0	0	7	0	6	1	4	1	1	1	4	0	0			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:42793503G>A	uc002otf.1	+	8	1345	c.1305G>A	c.(1303-1305)ACG>ACA	p.T435T		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				AGGACATGACGAGTGATGAGG	0.642			T	DUX4	soft tissue sarcoma								9	22					0	0	0	0	A	42793503	A	A	42793503	2	1	143	1	0	0	0	0	0	0	0	1	3439	1045	37	1		1	CIC	19	42793503	Silent	SNP	G	TCGA-CR-7372-01A-11D-2012-08	6278024	42793503	16335480	52	26276											
ZFP112	7771	broad.mit.edu	37	chr19	44832521	44832521	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatggtttttctccagtgtGaactctctgatggccttgaa	7	16	10	8	0	2	3	0	3	2	0	4	3	2	3	2	2	1	2	2	2	3	4			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:44832521G>T	uc010ejj.2	-	5	1920	c.1807C>A	c.(1807-1809)CAC>AAC	p.H603N	ZFP112_uc002ozc.3_Missense_Mutation_p.H597N|ZFP112_uc010xwy.1_Missense_Mutation_p.H620N|ZFP112_uc010xwz.1_Missense_Mutation_p.H602N	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	603	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TCTCCAGTGTGAACTCTCTGA	0.478													25	111					2.79863e-10	3.87503e-10	1	0	T	44832521	T	T	44832521	3	4	143	1	0	0	0	0	1	0	0	0	17705	1290	45	2	938	2	ZFP112	19	44832521	Missense_Mutation	SNP	G	TCGA-CR-7372-01A-11D-2012-08	2039018	44832521	14296462	53	26277											
ZNF473	25888	broad.mit.edu	37	chr19	50549981	50549981	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagaaaagccttatgtttgtCaggaatgcgggaaagccttc	12	10	12	7	1	1	1	1	0	0	1	2	4	1	3	2	2	3	1	2	2	5	3			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr19:50549981C>T	uc002prn.2	+	5	2518	c.2281C>T	c.(2281-2283)CAG>TAG	p.Q761*	ZNF473_uc002prm.2_Nonsense_Mutation_p.Q761*|ZNF473_uc010ybo.1_Nonsense_Mutation_p.Q749*	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	761	C2H2-type 17.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		TTATGTTTGTCAGGAATGCGG	0.522											OREG0025632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	84					0	0	0	0	T	50549981	T	T	50549981	4	4	143	1	0	0	0	0	0	1	0	0	17998	827	29	2	2295	2	ZNF473	19	50549981	Nonsense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08	5717460	50549981	8579002	54	26278											
SLC5A1	6523	broad.mit.edu	37	chr22	32498104	32498104	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggagctgcatggagcccagCaactgtcccacgattatctg	9	8	12	12	1	1	0	0	0	1	0	2	3	2	2	2	2	5	3	2	2	2	1			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chr22:32498104C>A	uc003amc.2	+	13	1777	c.1545C>A	c.(1543-1545)AGC>AGA	p.S515R	SLC5A1_uc011alz.1_Missense_Mutation_p.S388R	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	515	Extracellular (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						TGGAGCCCAGCAACTGTCCCA	0.498													15	130					2.32078e-09	3.15276e-09	1	0	A	32498104	A	A	32498104	3	1	143	1	0	0	0	0	1	0	0	0	14725	709	25	4	1595	4	SLC5A1	22	32498104	Missense_Mutation	SNP	C	TCGA-CR-7372-01A-11D-2012-08		32498104	18806462	55	26279											
DMD	1756	broad.mit.edu	37	chrX	31200900	31200900	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagatgttacatttggccTgatgcttggcagtttctgca	7	15	11	8	0	1	2	0	1	1	1	1	2	1	2	1	2	4	6	1	2	1	4			TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chrX:31200900T>C	uc004dda.1	-	68	10173	c.9929A>G	c.(9928-9930)CAG>CGG	p.Q3310R	DMD_uc004dcq.1_Missense_Mutation_p.Q581R|DMD_uc004dcr.1_Missense_Mutation_p.Q850R|DMD_uc004dcs.1_Missense_Mutation_p.Q850R|DMD_uc004dct.1_Missense_Mutation_p.Q850R|DMD_uc004dcu.1_Missense_Mutation_p.Q850R|DMD_uc004dcv.1_Missense_Mutation_p.Q850R|DMD_uc004dcw.2_Missense_Mutation_p.Q1966R|DMD_uc004dcx.2_Missense_Mutation_p.Q1969R|DMD_uc004dcz.2_Missense_Mutation_p.Q3187R|DMD_uc004dcy.1_Missense_Mutation_p.Q3306R|DMD_uc004ddb.1_Missense_Mutation_p.Q3302R|DMD_uc004dcm.1_Missense_Mutation_p.Q242R|DMD_uc004dcn.1_Missense_Mutation_p.Q242R|DMD_uc004dco.1_Missense_Mutation_p.Q242R|DMD_uc004dcp.1_Missense_Mutation_p.Q242R|DMD_uc011mkb.1_Missense_Mutation_p.Q242R|DMD_uc010ngm.2_Missense_Mutation_p.Q242R	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3310	Interaction with SYNM (By similarity).|ZZ-type.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ACATTTGGCCTGATGCTTGGC	0.458													3	57					0	0	0	0	C	31200900	C	C	31200900	3	2	143	1	0	0	0	0	1	0	0	0	4602	1580	55	5	1266	5	DMD	23	31200900	Missense_Mutation	SNP	T	TCGA-CR-7372-01A-11D-2012-08		31200900	124069660	56	26280											
PPP1R3F	89801	broad.mit.edu	37	chrX	49137917	49137919	+	In_Frame_Del	DEL	TGC	-	-																															aacatggatgataacaccttTgccatgggtaagcaattggc																										TCGA-CR-7372-01A-11D-2012-08	TCGA-CR-7372-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9032c525-9bed-47f9-b9f2-ecce4593ea37	067eb6e6-2211-467d-993f-f16368e1da5d	g.chrX:49137917_49137919delTGC	uc004dnh.1	+	2	1069_1071	c.1053_1055delTGC	c.(1051-1056)TTTGCC>TTC	p.A352del	PPP1R3F_uc011mnd.1_In_Frame_Del_p.A24del|PPP1R3F_uc004dni.2_In_Frame_Del_p.A7del|PPP1R3F_uc004dnj.1_In_Frame_Del_p.A7del	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	352	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					ATAACACCTTTGCCATGGGTAAG	0.404													---	---	---								-	49137919	-	-	49137917	7	5	143	1	0	1	0	1	0	0	0	0	12435	1809	63	0	1059	0	PPP1R3F	23	49137917	In_Frame_Del	DEL	TGC	TCGA-CR-7372-01A-11D-2012-08	17937017	49137917	106132643	57	26281											
KAZ	23254	broad.mit.edu	37	chr1	14925658	14925658	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcccgggagccgcggccagCgcctcggcggcgggggactc	3	2	20	16	7	0	0	0	0	0	0	2	2	0	2	4	7	2	0	4	7	0	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:14925658C>T	uc001avm.3	+	1	446	c.165C>T	c.(163-165)AGC>AGT	p.S55S	KAZ_uc009vog.1_Silent_p.S55S|KAZ_uc010obj.1_Silent_p.S55S	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	55					keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						ccgcggccagcgcctcggcgg	0.473													3	4					0	0	0	0	T	14925658	T	T	14925658	2	4	144	1	0	0	0	0	0	0	0	1	8027	767	27	1		1	KAZ	1	14925658	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08		14925658	234324963	1	26282											
IPO13	9670	broad.mit.edu	37	chr1	44415762	44415762	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttgctgctctgcaggactCggagctcttcgacagcagtg	6	11	12	12	2	2	0	0	0	2	0	4	3	2	2	0	2	5	5	0	2	0	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:44415762C>T	uc001ckx.2	+	2	1553	c.758C>T	c.(757-759)TCG>TTG	p.S253L		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	253	HEAT 3.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CTGCAGGACTCGGAGCTCTTC	0.577													12	27					0	0	0	0	T	44415762	T	T	44415762	3	4	144	1	0	0	0	0	1	0	0	0	7833	893	31	1	764	1	IPO13	1	44415762	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	29490104	44415762	204834859	2	26283											
DNTTIP2	30836	broad.mit.edu	37	chr1	94342345	94342345	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcaagtcacttgcttttatGgggctctttttgttgttatt	5	21	9	6	0	3	0	2	0	1	0	3	0	3	0	0	2	1	4	0	2	3	8			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:94342345G>A	uc001dqf.2	-	2	1184	c.1146C>T	c.(1144-1146)CCC>CCT	p.P382P	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Silent_p.P177P	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TTGCTTTTATGGGGCTCTTTT	0.398													139	171					0	0	0	0	A	94342345	A	A	94342345	2	1	144	1	0	0	0	0	0	0	0	1	4704	1335	47	4		4	DNTTIP2	1	94342345	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	49926583	94342345	154908276	3	26284											
DDX20	11218	broad.mit.edu	37	chr1	112309065	112309065	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcaaaggaaataagtcataCttggaaggctcttctgataa	16	10	9	6	0	3	1	1	1	2	0	3	3	3	3	0	3	2	2	0	3	6	5			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:112309065C>T	uc001ebs.2	+	11	2376	c.2019C>T	c.(2017-2019)TAC>TAT	p.Y673Y	DDX20_uc010owf.1_Silent_p.Y435Y|DDX20_uc001ebt.2_Silent_p.Y281Y	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	673					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAAGTCATACTTGGAAGGCT	0.453													14	43					0	0	0	0	T	112309065	T	T	112309065	2	4	144	1	0	0	0	0	0	0	0	1	4365	576	20	4		4	DDX20	1	112309065	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	17966720	112309065	136941556	4	26285											
FLG	2312	broad.mit.edu	37	chr1	152276170	152276170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggatccttgtcttcctccaGtactgggcccagcccgtcca	5	10	10	16	1	1	0	0	0	1	0	5	1	5	1	6	2	2	1	6	2	1	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:152276170G>A	uc001ezu.1	-	3	11228	c.11192C>T	c.(11191-11193)ACT>ATT	p.T3731I		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3731	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTTCCTCCAGTACTGGGCCC	0.617									Ichthyosis				139	307					0	0	0	0	A	152276170	A	A	152276170	3	1	144	1	0	0	0	0	1	0	0	0	5954	1029	36	4	997	4	FLG	1	152276170	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	39967105	152276170	96974451	5	26286											
IVL	3713	broad.mit.edu	37	chr1	152883939	152883939	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggccaggtccaagacattCaaccagccctgcccacaaag	13	4	8	16	0	1	1	1	0	0	1	2	1	2	1	5	2	3	0	5	2	3	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:152883939C>T	uc001fau.2	+	2	1712	c.1666C>T	c.(1666-1668)CAA>TAA	p.Q556*		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	556					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCAAGACATTCAACCAGCCCT	0.388													19	53					0	0	0	0	T	152883939	T	T	152883939	4	4	144	1	0	0	0	0	0	1	0	0	7968	827	29	2	1668	2	IVL	1	152883939	Nonsense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	607769	152883939	96366682	6	26287											
S100A2	6273	broad.mit.edu	37	chr1	153533987	153533987	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtgccaggaaaacagcataCtcctggaagtccacctgctg	12	7	10	12	0	0	0	0	0	0	0	2	2	2	2	4	2	5	2	4	2	4	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:153533987C>T	uc001fcb.2	-	3	560	c.222G>A	c.(220-222)GAG>GAA	p.E74E		NM_005978	NP_005969	P29034	S10A2_HUMAN	S100 calcium binding protein A2	75	EF-hand 2.|2; high affinity (Potential).				endothelial cell migration		calcium ion binding			ovary(1)	1	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAACAGCATACTCCTGGAAGT	0.527													56	149					0	0	0	0	T	153533987	T	T	153533987	2	4	144	1	0	0	0	0	0	0	0	1	13843	564	20	4		4	S100A2	1	153533987	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	650048	153533987	95716634	7	26288											
RAB13	5872	broad.mit.edu	37	chr1	153957221	153957221	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgtagtttgatcttcttcCcctctatatccacagtgcgg	6	16	7	12	1	3	1	0	1	3	0	5	1	5	1	3	1	1	2	3	1	3	7			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:153957221C>T	uc001fdt.1	-	2	255	c.161G>A	c.(160-162)GGG>GAG	p.G54E	RAB13_uc001fdu.1_Missense_Mutation_p.G54E	NM_002870	NP_002861	P51153	RAB13_HUMAN	RAB13, member RAS oncogene family	54					cell adhesion|protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	cytoplasmic vesicle membrane|tight junction	GTP binding|GTPase activity				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GATCTTCTTCCCCTCTATATC	0.448													4	31					0	0	0	0	T	153957221	T	T	153957221	3	4	144	1	0	0	0	0	1	0	0	0	12964	623	22	4	478	4	RAB13	1	153957221	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	423234	153957221	95293400	8	26289											
OR10J5	127385	broad.mit.edu	37	chr1	159505792	159505792	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttctgtgaagttctttctCttcattctgctatatcagtg	7	19	6	9	0	6	1	2	1	4	0	7	1	6	1	0	0	1	2	0	0	3	7			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:159505792C>G	uc010piw.1	-	1	6	c.6G>C	c.(4-6)AAG>AAC	p.K2N		NM_001004469	NP_001004469	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_hematologic(112;0.0429)					AGTTCTTTCTCTTCATTCTGC	0.348													14	32					0	0	0	0	G	159505792	G	G	159505792	3	3	144	1	0	0	0	0	1	0	0	0	10966	912	32	2	925	2	OR10J5	1	159505792	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	5548571	159505792	89744829	9	26290											
ATP1A2	477	broad.mit.edu	37	chr1	160109482	160109482	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacggcgttggctgcctttCtctcttactgcccaggcatg	5	12	11	13	2	2	1	0	0	2	1	3	1	2	1	2	3	3	3	2	3	1	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:160109482C>A	uc001fvc.2	+	21	3025	c.2893C>A	c.(2893-2895)CTC>ATC	p.L965I	ATP1A2_uc001fvd.2_Missense_Mutation_p.L684I	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	965	Helical; (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GGCTGCCTTTCTCTCTTACTG	0.582													18	51					6.49762e-13	9.52391e-13	1	0	A	160109482	A	A	160109482	3	1	144	1	0	0	0	0	1	0	0	0	1131	913	32	2	2975	2	ATP1A2	1	160109482	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	603690	160109482	89141139	10	26291											
RXRG	6258	broad.mit.edu	37	chr1	165378880	165378880	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaggatgccatcctgcaCggaaactgagcggtgggaga	12	5	15	9	2	0	3	0	1	0	2	1	6	1	5	2	4	4	1	2	4	2	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:165378880C>T	uc001gda.2	-	7	1261	c.961G>A	c.(961-963)GTG>ATG	p.V321M		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	321	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CCATCCTGCACGGAAACTGAG	0.517													8	21					0	0	0	0	T	165378880	T	T	165378880	3	4	144	1	0	0	0	0	1	0	0	0	13830	536	19	1	446	1	RXRG	1	165378880	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	5269398	165378880	83871741	11	26292											
PTPRC	5788	broad.mit.edu	37	chr1	198685828	198685828	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaaaaagattgcctcaatCtggataaaaacctgatcaaa	19	8	6	8	0	3	3	2	1	1	2	3	4	3	4	2	1	2	0	2	1	7	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:198685828C>G	uc001gur.1	+	13	1483	c.1303C>G	c.(1303-1305)CTG>GTG	p.L435V	PTPRC_uc001gus.1_Missense_Mutation_p.L387V|PTPRC_uc001gut.1_Missense_Mutation_p.L274V|PTPRC_uc009wzf.1_Missense_Mutation_p.L323V|PTPRC_uc010ppg.1_Missense_Mutation_p.L371V	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	435	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TTGCCTCAATCTGGATAAAAA	0.303													12	54					0	0	0	0	G	198685828	G	G	198685828	3	3	144	1	0	0	0	0	1	0	0	0	12862	912	32	2	1360	2	PTPRC	1	198685828	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	33306948	198685828	50564793	12	26293											
DUSP10	11221	broad.mit.edu	37	chr1	221913036	221913036	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgagatcctgaggtcggacGggcctagatagtgccactac	9	9	13	10	2	0	3	0	2	0	2	2	5	1	4	3	3	2	0	3	3	3	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:221913036G>A	uc001hmy.1	-	2	233	c.51C>T	c.(49-51)CCC>CCT	p.P17P	DUSP10_uc001hmx.1_5'Flank|DUSP10_uc001hmz.1_Intron	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	17					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		GAGGTCGGACGGGCCTAGATA	0.517													33	76					0	0	0	0	A	221913036	A	A	221913036	2	1	144	1	0	0	0	0	0	0	0	1	4832	1103	39	1		1	DUSP10	1	221913036	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	23227208	221913036	27337585	13	26294											
KIAA1383	54627	broad.mit.edu	37	chr1	232941709	232941709	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataatcgagtgggcgagcggActggggacattgcactggcc	9	7	16	9	3	0	0	0	0	0	0	1	4	0	2	1	5	2	1	1	5	1	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:232941709A>G	uc001hvh.2	+	1	1072	c.940A>G	c.(940-942)ACT>GCT	p.T314A		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	172										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				GGGCGAGCGGACTGGGGACAT	0.692													10	17					0	0	0	0	G	232941709	G	G	232941709	3	3	144	1	0	0	0	0	1	0	0	0	8267	275	10	5	942	5	KIAA1383	1	232941709	Missense_Mutation	SNP	A	TCGA-CR-7373-01A-11D-2012-08	11028673	232941709	16308912	14	26295											
C2orf44	80304	broad.mit.edu	37	chr2	24261267	24261267	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagatggaatgacagagtaGatcaaaattatattacaagt	19	10	9	3	0	1	4	1	1	0	3	1	6	1	5	0	1	1	1	0	1	9	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:24261267G>C	uc002rep.2	-	2	1229	c.1098C>G	c.(1096-1098)ATC>ATG	p.I366M	C2orf44_uc010eya.2_Missense_Mutation_p.I366M	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	366							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACAGAGTAGATCAAAATTA	0.393													20	65					0	0	0	0	C	24261267	C	C	24261267	3	2	144	1	0	0	0	0	1	0	0	0	2178	932	33	2	1079	2	C2orf44	2	24261267	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08		24261267	218938106	15	26296			1	39		3	3	481	G		2.314428e-06
C2orf44	80304	broad.mit.edu	37	chr2	24261335	24261335	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttaagattaaatgctatcaGatcaggaaccagaatgcctg	15	11	8	7	0	2	3	2	0	0	3	2	4	2	4	2	1	3	1	2	1	6	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:24261335G>A	uc002rep.2	-	2	1161	c.1030C>T	c.(1030-1032)CTG>TTG	p.L344L	C2orf44_uc010eya.2_Silent_p.L344L	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	344							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATGCTATCAGATCAGGAACC	0.413													16	44					0	0	0	0	A	24261335	A	A	24261335	2	1	144	1	0	0	0	0	0	0	0	1	2178	933	33	2		2	C2orf44	2	24261335	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	68	24261335	218938038	16	26297			1	39		3	3	481	G		2.314428e-06
C2orf44	80304	broad.mit.edu	37	chr2	24261747	24261747	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagttgctgtgatggagcaGacgtggctgtccacatcaaa	11	9	12	9	1	1	2	1	1	0	1	2	3	2	3	1	2	2	4	1	2	1	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:24261747G>C	uc002rep.2	-	2	749	c.618C>G	c.(616-618)GTC>GTG	p.V206V	C2orf44_uc010eya.2_Silent_p.V206V	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	206							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATGGAGCAGACGTGGCTGT	0.488													15	47					0	0	0	0	C	24261747	C	C	24261747	2	2	144	1	0	0	0	0	0	0	0	1	2178	929	33	2		2	C2orf44	2	24261747	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	412	24261747	218937626	17	26298			1	39		3	3	481	G		2.314428e-06
ALK	238	broad.mit.edu	37	chr2	29443686	29443686	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaatgcagcgaacaatgttCtggtggttgaatttgctgca	10	12	11	8	1	1	1	0	1	1	0	1	2	1	1	1	2	5	5	1	2	4	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:29443686C>G	uc002rmy.2	-	23	4438	c.3531G>C	c.(3529-3531)CAG>CAC	p.Q1177H	ALK_uc010ymo.1_Missense_Mutation_p.Q109H	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1177	Protein kinase.|Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GAACAATGTTCTGGTGGTTGA	0.517			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				13	28					0	0	0	0	G	29443686	G	G	29443686	3	3	144	1	0	0	0	0	1	0	0	0	525	912	32	2	1359	2	ALK	2	29443686	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	5181939	29443686	213755687	18	26299											
SMEK2	57223	broad.mit.edu	37	chr2	55812192	55812192	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcattattacttacgtcatCactctgctgagcttcttgca	9	15	6	11	1	4	1	2	1	2	0	4	1	4	1	0	0	6	4	0	0	3	5			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:55812192C>T	uc002rzc.2	-	7	1603	c.1228G>A	c.(1228-1230)GAT>AAT	p.D410N	SMEK2_uc002rzb.2_Missense_Mutation_p.D410N|SMEK2_uc002rzd.2_Missense_Mutation_p.D410N|SMEK2_uc002rza.2_Missense_Mutation_p.D286N	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	410						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTTACGTCATCACTCTGCTGA	0.348													15	48					0	0	0	0	T	55812192	T	T	55812192	3	4	144	1	0	0	0	0	1	0	0	0	14858	826	29	2	1365	2	SMEK2	2	55812192	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	26368506	55812192	187387181	19	26300											
TMEM131	23505	broad.mit.edu	37	chr2	98408979	98408979	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtcctcggaactgtgcctCgcgctgctggcacgttctgg	4	10	14	13	4	1	0	0	0	1	0	4	2	2	1	2	3	3	4	2	3	1	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:98408979C>T	uc002syh.3	-	31	4243	c.4014G>A	c.(4012-4014)GCG>GCA	p.A1338A		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1338						integral to membrane				ovary(4)|central_nervous_system(2)	6						AACTGTGCCTCGCGCTGCTGG	0.622													5	22					0	0	0	0	T	98408979	T	T	98408979	2	4	144	1	0	0	0	0	0	0	0	1	16110	871	31	1		1	TMEM131	2	98408979	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	42596787	98408979	144790394	20	26301											
COL5A2	1290	broad.mit.edu	37	chr2	189953461	189953461	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctacttgactcccaagtccaGatttttcatccaacccagcc	10	11	4	16	0	1	2	1	1	0	1	4	2	4	2	5	0	3	0	5	0	3	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:189953461G>C	uc002uqk.2	-	8	880	c.605C>G	c.(604-606)TCT>TGT	p.S202C	COL5A2_uc010frx.2_5'Flank	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	202					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCAAGTCCAGATTTTTCATC	0.353													18	49					0	0	0	0	C	189953461	C	C	189953461	3	2	144	1	0	0	0	0	1	0	0	0	3712	942	33	2	4082	2	COL5A2	2	189953461	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	91544482	189953461	53245912	21	26302											
SP140	11262	broad.mit.edu	37	chr2	231112687	231112687	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catacagcacagcaccagggGagaaacagggagaggaggaa	17	1	15	8	0	0	2	0	0	0	2	0	6	0	4	1	5	4	2	1	5	3	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:231112687G>A	uc002vql.2	+	8	914	c.799G>A	c.(799-801)GAG>AAG	p.E267K	SP140_uc010zma.1_Intron|SP140_uc002vqk.2_Missense_Mutation_p.E267K|SP140_uc002vqn.2_Intron|SP140_uc002vqm.2_Missense_Mutation_p.E241K|SP140_uc010fxl.2_Missense_Mutation_p.E267K	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	267					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGCACCAGGGGAGAAACAGGG	0.473													46	38					0	0	0	0	A	231112687	A	A	231112687	3	1	144	1	0	0	0	0	1	0	0	0	15026	1175	41	2	946	2	SP140	2	231112687	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	41159226	231112687	12086686	22	26303											
PRRT3	285368	broad.mit.edu	37	chr3	9989488	9989488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagggggccccagcgtagcgGgggtgcagtggcgttggctg	5	6	21	9	3	0	0	0	0	0	0	0	0	0	0	2	6	3	4	2	6	2	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:9989488G>A	uc003bul.2	-	4	1499	c.1369C>T	c.(1369-1371)CCG>TCG	p.P457S	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	457	Extracellular (Potential).|Pro-rich.					integral to membrane					0						CAGCGTAGCGGGGGTGCAGTG	0.716													3	5					0	0	0	0	A	9989488	A	A	9989488	3	1	144	1	0	0	0	0	1	0	0	0	12673	1232	43	4	1580	4	PRRT3	3	9989488	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08		9989488	188032942	23	26304											
ZNF621	285268	broad.mit.edu	37	chr3	40570902	40570902	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggccctgtacggggaggtGatgctggagaattatgcaaa	11	8	16	6	1	0	2	0	1	0	1	0	4	0	3	1	5	3	3	1	5	4	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:40570902G>A	uc003ckm.2	+	3	333	c.117G>A	c.(115-117)GTG>GTA	p.V39V	ZNF621_uc003ckn.2_Silent_p.V39V|ZNF621_uc003cko.2_Intron|ZNF621_uc011aze.1_Intron	NM_001098414	NP_001091884	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		ACGGGGAGGTGATGCTGGAGA	0.517													57	85					0	0	0	0	A	40570902	A	A	40570902	2	1	144	1	0	0	0	0	0	0	0	1	18112	1277	45	2		2	ZNF621	3	40570902	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	30581414	40570902	157451528	24	26305											
CLDND1	56650	broad.mit.edu	37	chr3	98240146	98240146	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttattcaaatcactggaattTtcttgaactggacttcgata	12	16	6	7	1	3	1	2	1	1	0	4	4	3	3	0	2	1	0	0	2	5	7			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:98240146T>G	uc003dsp.2	-	2	1003	c.123A>C	c.(121-123)GAA>GAC	p.E41D	CLDND1_uc003dso.2_Missense_Mutation_p.E41D|CLDND1_uc003dsq.2_Missense_Mutation_p.E41D|CLDND1_uc003dss.2_Missense_Mutation_p.E41D|CLDND1_uc003dsr.2_Intron|CLDND1_uc003dst.2_Missense_Mutation_p.E64D|CLDND1_uc003dsu.2_Missense_Mutation_p.E41D|CLDND1_uc003dsv.2_Missense_Mutation_p.E41D	NM_019895	NP_063948	Q9NY35	CLDN1_HUMAN	claudin domain containing 1 protein isoform a	41						integral to membrane				ovary(1)	1						CACTGGAATTTTCTTGAACTG	0.393													15	46					0	0	0	0	G	98240146	G	G	98240146	3	3	144	1	0	0	0	0	1	0	0	0	3508	1838	64	5	654	5	CLDND1	3	98240146	Missense_Mutation	SNP	T	TCGA-CR-7373-01A-11D-2012-08	57669244	98240146	99782284	25	26306											
ARGFX	503582	broad.mit.edu	37	chr3	121303817	121303817	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcacccaccaacagtatgagGagctagaagctctgtttagc	12	9	9	11	0	2	2	1	1	1	1	2	3	2	3	2	1	4	4	2	1	5	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:121303817G>C	uc003eef.2	+	4	369	c.274G>C	c.(274-276)GAG>CAG	p.E92Q		NM_001012659	NP_001012677	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	92	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(114;0.152)		ACAGTATGAGGAGCTAGAAGC	0.443													30	116					0	0	0	0	C	121303817	C	C	121303817	3	2	144	1	0	0	0	0	1	0	0	0	859	1175	41	2	284	2	ARGFX	3	121303817	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	23063671	121303817	76718613	26	26307											
MYLK	4638	broad.mit.edu	37	chr3	123383036	123383036	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccgcagtgctcctggcGcgcggccaggatggtgagct	5	6	17	13	4	0	1	0	1	0	0	1	2	1	2	3	4	3	4	3	4	0	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:123383036G>A	uc003ego.2	-	23	4183	c.3901C>T	c.(3901-3903)CGC>TGC	p.R1301C	MYLK_uc010hrr.2_5'UTR|MYLK_uc011bjv.1_Missense_Mutation_p.R101C|MYLK_uc011bjw.1_Missense_Mutation_p.R1301C|MYLK_uc003egp.2_Missense_Mutation_p.R1232C|MYLK_uc003egq.2_Missense_Mutation_p.R1301C|MYLK_uc003egr.2_Missense_Mutation_p.R1232C|MYLK_uc003egs.2_Missense_Mutation_p.R1125C	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1301	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 8.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGCTCCTGGCGCGCGGCCAGG	0.627													51	171					0	0	0	0	A	123383036	A	A	123383036	3	1	144	1	0	0	0	0	1	0	0	0	10109	1087	38	1	1891	1	MYLK	3	123383036	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	2079219	123383036	74639394	27	26308											
MECOM	2122	broad.mit.edu	37	chr3	168834351	168834351	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgccttggccaaaaaatcCacctgccgcaaaatggttct	13	9	7	12	1	1	0	0	0	1	0	2	0	2	0	5	2	2	2	5	2	6	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:168834351C>A	uc003ffi.3	-	7	1014	c.745G>T	c.(745-747)GGA>TGA	p.G249*	MECOM_uc010hwk.1_Nonsense_Mutation_p.G272*|MECOM_uc003ffj.3_Nonsense_Mutation_p.G314*|MECOM_uc011bpi.1_Nonsense_Mutation_p.G250*|MECOM_uc003ffn.3_Nonsense_Mutation_p.G249*|MECOM_uc003ffk.2_Nonsense_Mutation_p.G249*|MECOM_uc003ffl.2_Nonsense_Mutation_p.G409*|MECOM_uc011bpj.1_Nonsense_Mutation_p.G437*|MECOM_uc011bpk.1_Nonsense_Mutation_p.G239*|MECOM_uc010hwn.2_Nonsense_Mutation_p.G437*	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	249	Interaction with MAPK9, SMAD3 and probably SUV39H1.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CCAAAAAATCCACCTGCCGCA	0.453													18	59					1.2644e-06	1.79194e-06	1	0	A	168834351	A	A	168834351	4	1	144	1	0	0	0	0	0	1	0	0	9475	603	21	4	2450	4	MECOM	3	168834351	Nonsense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	45451315	168834351	29188079	28	26309											
MYNN	55892	broad.mit.edu	37	chr3	169496734	169496734	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgtcttcttactctgcgaGattataataatcgagagaaa	13	14	7	7	2	3	2	0	0	3	2	4	5	3	2	0	0	2	0	0	0	5	6			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:169496734G>C	uc003fft.2	+	3	874	c.445G>C	c.(445-447)GAT>CAT	p.D149H	MYNN_uc011bpm.1_Missense_Mutation_p.D35H|MYNN_uc003ffu.2_Missense_Mutation_p.D149H|MYNN_uc003ffv.2_5'UTR|MYNN_uc010hwo.2_Missense_Mutation_p.D149H|MYNN_uc003ffw.1_RNA	NM_018657	NP_061127	Q9NPC7	MYNN_HUMAN	myoneurin	149						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TACTCTGCGAGATTATAATAA	0.343													21	36					0	0	0	0	C	169496734	C	C	169496734	3	2	144	1	0	0	0	0	1	0	0	0	10114	942	33	2	451	2	MYNN	3	169496734	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	662383	169496734	28525696	29	26310											
SRD5A3	79644	broad.mit.edu	37	chr4	56230347	56230347	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgtcttctccaatgtcatGattcacgtcgtgcagtactg	8	14	9	10	2	4	1	2	1	2	0	6	1	4	1	1	0	2	2	1	0	2	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr4:56230347G>C	uc003hau.2	+	3	566	c.471G>C	c.(469-471)ATG>ATC	p.M157I	uc003hav.1_RNA	NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	157	Lumenal (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			CCAATGTCATGATTCACGTCG	0.483													16	72					0	0	0	0	C	56230347	C	C	56230347	3	2	144	1	0	0	0	0	1	0	0	0	15206	1290	45	2	481	2	SRD5A3	4	56230347	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08		56230347	134923929	30	26311											
MAP1B	4131	broad.mit.edu	37	chr5	71491499	71491499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaagaaagattctgttgctGccggaaagccaaaggagaag	15	7	12	7	1	2	3	1	0	1	3	2	5	2	4	2	2	3	2	2	2	5	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:71491499G>A	uc003kbw.3	+	5	2558	c.2317G>A	c.(2317-2319)GCC>ACC	p.A773T	MAP1B_uc010iyw.1_Missense_Mutation_p.A790T|MAP1B_uc010iyx.1_Missense_Mutation_p.A647T|MAP1B_uc010iyy.1_Missense_Mutation_p.A647T	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	773	Lys-rich (highly basic, contains many KKEE and KKEI/V repeats).					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TTCTGTTGCTGCCGGAAAGCC	0.473													37	124					0	0	0	0	A	71491499	A	A	71491499	3	1	144	1	0	0	0	0	1	0	0	0	9281	1319	46	4	2335	4	MAP1B	5	71491499	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08		71491499	109423761	31	26312											
VCAN	1462	broad.mit.edu	37	chr5	82808041	82808041	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaggcggcatggaggaacGgctttgaccagtgcgattac	9	8	14	10	3	0	1	0	1	0	0	1	4	1	3	2	5	3	2	2	5	2	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:82808041G>A	uc003kii.3	+	6	1224	c.868G>A	c.(868-870)GGC>AGC	p.G290S	VCAN_uc003kij.3_Missense_Mutation_p.G290S|VCAN_uc010jau.2_Missense_Mutation_p.G290S|VCAN_uc003kik.3_Missense_Mutation_p.G290S|VCAN_uc003kih.3_Missense_Mutation_p.G290S	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	290	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ATGGAGGAACGGCTTTGACCA	0.602													15	26					0	0	0	0	A	82808041	A	A	82808041	3	1	144	1	0	0	0	0	1	0	0	0	17206	1116	39	1	886	1	VCAN	5	82808041	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	11316542	82808041	98107219	32	26313											
SEC24A	10802	broad.mit.edu	37	chr5	134007526	134007526	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaaataccaataacggatCtatggtggtccacagtagtt	14	11	8	8	1	2	0	1	0	1	0	3	1	3	1	2	3	2	2	2	3	6	5			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:134007526C>G	uc003kzs.2	+	4	1055	c.767C>G	c.(766-768)TCT>TGT	p.S256C	SEC24A_uc011cxu.1_Missense_Mutation_p.L24V	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	256					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AATAACGGATCTATGGTGGTC	0.308													12	27					0	0	0	0	G	134007526	G	G	134007526	3	3	144	1	0	0	0	0	1	0	0	0	14059	913	32	2	781	2	SEC24A	5	134007526	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	51199485	134007526	46907734	33	26314											
PCDHA5	56143	broad.mit.edu	37	chr5	140203521	140203521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctgctgtacaccgcgctgCggtgctcggcgcagcccacc	4	7	13	17	5	0	0	0	0	0	0	1	0	0	0	3	2	6	6	3	2	1	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:140203521C>T	uc003lhl.2	+	1	2161	c.2161C>T	c.(2161-2163)CGG>TGG	p.R721W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R721W|PCDHA5_uc003lhj.1_Missense_Mutation_p.R721W	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	721	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCGCGCTGCGGTGCTCGGC	0.667													33	69					0	0	0	0	T	140203521	T	T	140203521	3	4	144	1	0	0	0	0	1	0	0	0	11581	759	27	1	2163	1	PCDHA5	5	140203521	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	6195995	140203521	40711739	34	26315											
PCDHGA4	56111	broad.mit.edu	37	chr5	140735144	140735144	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaggtggaaataatcgatgTtaatgataacccacccagtt	15	10	9	7	1	0	2	0	1	0	1	1	4	0	3	2	2	1	2	2	2	4	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:140735144T>C	uc003ljq.1	+	1	377	c.377T>C	c.(376-378)GTT>GCT	p.V126A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.V126A	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	126	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAATCGATGTTAATGATAAC	0.423													19	36					0	0	0	0	C	140735144	C	C	140735144	3	2	144	1	0	0	0	0	1	0	0	0	11610	1725	60	5	379	5	PCDHGA4	5	140735144	Missense_Mutation	SNP	T	TCGA-CR-7373-01A-11D-2012-08	531623	140735144	40180116	35	26316											
TCOF1	6949	broad.mit.edu	37	chr5	149754239	149754239	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcagcccctgccaaggagtcCcccaggaaaggagctgcccc	9	4	11	17	0	1	0	1	0	0	0	2	3	2	3	7	3	4	1	7	3	2	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:149754239C>A	uc003lry.2	+	9	1251	c.1143C>A	c.(1141-1143)TCC>TCA	p.S381S	TCOF1_uc003lrw.2_Silent_p.S381S|TCOF1_uc011dch.1_Silent_p.S381S|TCOF1_uc003lrz.2_Silent_p.S381S|TCOF1_uc003lrx.2_Silent_p.S304S|TCOF1_uc003lsa.2_Silent_p.S304S|TCOF1_uc011dci.1_5'Flank	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	381					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAAGGAGTCCCCCAGGAAAG	0.657													20	66					1.2644e-06	1.79194e-06	1	0	A	149754239	A	A	149754239	2	1	144	1	0	0	0	0	0	0	0	1	15774	610	22	4		4	TCOF1	5	149754239	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	9019095	149754239	31161021	36	26317											
MYLK4	340156	broad.mit.edu	37	chr6	2675332	2675332	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgacaaccaggggtgcttGagagcttcgcttgcacttat	8	12	11	10	1	1	2	0	2	1	1	2	3	1	2	1	2	4	4	1	2	2	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:2675332G>C	uc003mty.3	-	11	1365	c.1068C>G	c.(1066-1068)CTC>CTG	p.L356L	MYLK4_uc003mtx.3_Silent_p.L71L	NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	356	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				AGGGGTGCTTGAGAGCTTCGC	0.488													25	66					0	0	0	0	C	2675332	C	C	2675332	2	2	144	1	0	0	0	0	0	0	0	1	10112	1277	45	2		2	MYLK4	6	2675332	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08		2675332	168439735	37	26318											
ZNF184	7738	broad.mit.edu	37	chr6	27420303	27420303	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttccataaagtggcctctCtggctaaaggcttttccaca	9	13	8	11	0	1	0	0	0	1	0	4	0	3	0	3	3	0	3	3	3	4	5			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:27420303C>G	uc003njj.2	-	5	1846	c.1035G>C	c.(1033-1035)CAG>CAC	p.Q345H	ZNF184_uc010jqv.2_Missense_Mutation_p.Q345H|ZNF184_uc003nji.2_Missense_Mutation_p.Q345H	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	345	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGTGGCCTCTCTGGCTAAAGG	0.423													6	30					0	0	0	0	G	27420303	G	G	27420303	3	3	144	1	0	0	0	0	1	0	0	0	17818	912	32	2	1224	2	ZNF184	6	27420303	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	24744971	27420303	143694764	38	26319											
HLA-A	3105	broad.mit.edu	37	chr6	29910349	29910349	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatggccgtcatggcgcccCgaaccctcctcctgctactc	5	8	10	18	3	1	0	1	0	0	0	4	2	3	1	6	3	3	1	6	3	2	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:29910349C>T	uc003nol.2	+	1	19	c.19C>T	c.(19-21)CGA>TGA	p.R7*	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Nonsense_Mutation_p.R7*|HLA-A_uc003noo.2_Nonsense_Mutation_p.R7*|HLA-A_uc010jrr.2_Nonsense_Mutation_p.R7*|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_5'Flank|HLA-A_uc011dmc.1_5'Flank|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	7					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CATGGCGCCCCGAACCCTCCT	0.677									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			17	65					0	0	0	0	T	29910349	T	T	29910349	4	4	144	1	0	0	0	0	0	1	0	0	7234	644	23	1	21	1	HLA-A	6	29910349	Nonsense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	2490046	29910349	141204718	39	26320											
VPS52	6293	broad.mit.edu	37	chr6	33219368	33219368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactcagagattccactgatGatttccaggaactaccaaag	14	9	8	10	0	1	3	1	2	0	1	3	6	3	4	3	1	2	0	3	1	3	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:33219368G>A	uc003odm.1	-	19	2162	c.1952C>T	c.(1951-1953)TCA>TTA	p.S651L	VPS52_uc003odn.1_Missense_Mutation_p.S462L	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	651					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						TTCCACTGATGATTTCCAGGA	0.507													30	74					0	0	0	0	A	33219368	A	A	33219368	3	1	144	1	0	0	0	0	1	0	0	0	17282	1294	45	2	227	2	VPS52	6	33219368	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	3309019	33219368	137895699	40	26321											
LRFN2	57497	broad.mit.edu	37	chr6	40359913	40359913	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtttggccttgccctccaaCggcaaggggagcaggctcct	6	8	13	14	2	0	0	0	0	0	0	2	1	2	1	4	5	3	4	4	5	2	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:40359913C>T	uc003oph.1	-	3	2604	c.2139G>A	c.(2137-2139)CCG>CCA	p.P713P		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	713	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGCCCTCCAACGGCAAGGGGA	0.736													5	14					0	0	0	0	T	40359913	T	T	40359913	2	4	144	1	0	0	0	0	0	0	0	1	8988	523	19	1		1	LRFN2	6	40359913	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	7140545	40359913	130755154	41	26322											
NCR2	9436	broad.mit.edu	37	chr6	41318601	41318601	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatgatgaacacactttgtGaataataaaattatctgaat	17	14	6	4	0	1	5	0	5	1	0	1	5	1	5	0	0	1	0	0	0	7	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:41318601G>A	uc003oqh.2	+	5	917	c.830G>A	c.(829-831)TGA>TAA	p.*277*	NCR2_uc003oqi.2_3'UTR|NCR2_uc003oqj.2_3'UTR	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	277					cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					cacactttgtgaataataaaa	0.169													15	39					0	0	0	0	A	41318601	A	A	41318601	2	1	144	1	0	0	0	0	0	0	0	1	10292	1285	45	2		2	NCR2	6	41318601	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	958688	41318601	129796466	42	26323											
MAN1A1	4121	broad.mit.edu	37	chr6	119501047	119501047	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atagggagaagatgtgcctcGctattgaagatccaatgctc	12	10	11	8	1	0	4	0	1	0	3	3	5	1	4	2	1	2	2	2	1	5	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:119501047G>A	uc003pym.1	-	13	2341	c.1899C>T	c.(1897-1899)AGC>AGT	p.S633S		NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	633	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		GATGTGCCTCGCTATTGAAGA	0.378													9	39					0	0	0	0	A	119501047	A	A	119501047	2	1	144	1	0	0	0	0	0	0	0	1	9263	1078	38	1		1	MAN1A1	6	119501047	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	78182446	119501047	51614020	43	26324											
NCOA7	135112	broad.mit.edu	37	chr6	126203622	126203622	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccattgaaagagtcttatcGtctacttctgaagaagatga	13	12	8	8	1	3	6	0	3	3	3	4	6	3	6	1	0	1	0	1	0	5	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:126203622G>A	uc010kes.2	+	9	1073	c.624G>A	c.(622-624)TCG>TCA	p.S208S	NCOA7_uc003qae.3_Silent_p.S208S|NCOA7_uc003qah.2_Silent_p.S208S|NCOA7_uc003qai.2_Silent_p.S208S|NCOA7_uc010ket.2_Silent_p.S104S|NCOA7_uc003qaf.2_Silent_p.S208S|NCOA7_uc003qag.2_Silent_p.S208S	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	208					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		GAGTCTTATCGTCTACTTCTG	0.348													7	39					0	0	0	0	A	126203622	A	A	126203622	2	1	144	1	0	0	0	0	0	0	0	1	10288	1132	40	1		1	NCOA7	6	126203622	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	6702575	126203622	44911445	44	26325											
NCOA7	135112	broad.mit.edu	37	chr6	126210917	126210917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcgggtgatcccataactGagggcaataaagagccagat	14	6	13	8	1	0	4	0	2	0	2	1	4	1	4	2	3	2	1	2	3	4	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:126210917G>A	uc010kes.2	+	11	2166	c.1717G>A	c.(1717-1719)GAG>AAG	p.E573K	NCOA7_uc003qae.3_Missense_Mutation_p.E573K|NCOA7_uc003qah.2_Missense_Mutation_p.E562K|NCOA7_uc003qai.2_Missense_Mutation_p.E573K|NCOA7_uc010ket.2_Missense_Mutation_p.E458K	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	573					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		TCCCATAACTGAGGGCAATAA	0.438													13	43					0	0	0	0	A	126210917	A	A	126210917	3	1	144	1	0	0	0	0	1	0	0	0	10288	1291	45	2	1747	2	NCOA7	6	126210917	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	7295	126210917	44904150	45	26326											
SYNE1	23345	broad.mit.edu	37	chr6	152706952	152706952	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagatgatctttcacaatctCttccactttcctcatttttt	8	20	2	11	0	4	2	2	1	2	1	7	2	6	2	2	0	0	0	2	0	2	7			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:152706952C>T	uc010kiw.2	-	55	9111	c.8509G>A	c.(8509-8511)GAG>AAG	p.E2837K	SYNE1_uc003qot.3_Missense_Mutation_p.E2844K|SYNE1_uc003qou.3_Missense_Mutation_p.E2837K|SYNE1_uc010kjb.1_Missense_Mutation_p.E2820K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2837	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCACAATCTCTTCCACTTTC	0.408										HNSCC(10;0.0054)			19	79					0	0	0	0	T	152706952	T	T	152706952	3	4	144	1	0	0	0	0	1	0	0	0	15511	922	32	2	18325	2	SYNE1	6	152706952	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	26496035	152706952	18408115	46	26327											
QKI	9444	broad.mit.edu	37	chr6	163876442	163876442	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactttatgtgcctgtaaaaGaatacccagatgtaagtata	16	12	7	6	0	0	2	0	0	0	2	0	2	0	2	2	0	3	3	2	0	9	7			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:163876442G>C	uc003qui.2	+	2	825	c.274G>C	c.(274-276)GAA>CAA	p.E92Q	QKI_uc003que.2_Missense_Mutation_p.E92Q|QKI_uc003quf.2_Missense_Mutation_p.E92Q|QKI_uc003qug.2_Missense_Mutation_p.E92Q|QKI_uc003quh.2_Missense_Mutation_p.E92Q|QKI_uc003quj.2_Missense_Mutation_p.E92Q	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	92	KH.				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		GCCTGTAAAAGAATACCCAGA	0.343													24	54					0	0	0	0	C	163876442	C	C	163876442	3	2	144	1	0	0	0	0	1	0	0	0	12938	943	33	2	280	2	QKI	6	163876442	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	11169490	163876442	7238625	47	26328											
DGKB	1607	broad.mit.edu	37	chr7	14378224	14378224	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctattcgtcgatggcttcGtcttttcttagactctcccc	4	17	6	14	3	4	1	0	0	4	1	8	2	4	1	2	1	0	1	2	1	2	6			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:14378224G>A	uc003ssz.2	-	22	2228	c.2041C>T	c.(2041-2043)CGA>TGA	p.R681*	DGKB_uc011jxt.1_Nonsense_Mutation_p.R662*|DGKB_uc003sta.2_Nonsense_Mutation_p.R681*|DGKB_uc011jxu.1_Nonsense_Mutation_p.R680*	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	681					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	CGATGGCTTCGTCTTTTCTTA	0.398													30	68					0	0	0	0	A	14378224	A	A	14378224	4	1	144	1	0	0	0	0	0	1	0	0	4488	1153	40	1	404	1	DGKB	7	14378224	Nonsense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08		14378224	144760439	48	26329											
GRM3	2913	broad.mit.edu	37	chr7	86468769	86468769	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgtgcattgcgccgactcGggctggggagttccttcgct	3	12	14	12	4	1	0	0	0	1	0	4	2	2	1	2	3	2	4	2	3	0	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:86468769G>A	uc003uid.2	+	4	3038	c.1939G>A	c.(1939-1941)GGG>AGG	p.G647R	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.G519R|GRM3_uc010leh.2_Missense_Mutation_p.G239R	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	647	Helical; Name=3; (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCGCCGACTCGGGCTGGGGAG	0.527													53	136					0	0	0	0	A	86468769	A	A	86468769	3	1	144	1	0	0	0	0	1	0	0	0	6837	1116	39	1	1949	1	GRM3	7	86468769	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	72090545	86468769	72669894	49	26330											
ZNF789	285989	broad.mit.edu	37	chr7	99084583	99084583	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacggtccataaacagtgTcacctgcaaaacaagccata	15	8	6	12	1	1	0	1	0	0	0	2	0	2	0	3	1	5	1	3	1	7	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:99084583T>G	uc003uqq.1	+	5	969	c.750T>G	c.(748-750)TGT>TGG	p.C250W	ZNF789_uc010lfw.1_Missense_Mutation_p.C155W|ZNF789_uc003uqr.1_Missense_Mutation_p.C192W	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	zinc finger protein 789 isoform 1	250	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					ATAAACAGTGTCACCTGCAAA	0.428													27	67					0	0	0	0	G	99084583	G	G	99084583	3	3	144	1	0	0	0	0	1	0	0	0	18227	1673	58	5	806	5	ZNF789	7	99084583	Missense_Mutation	SNP	T	TCGA-CR-7373-01A-11D-2012-08	12615814	99084583	60054080	50	26331											
WASL	8976	broad.mit.edu	37	chr7	123346798	123346798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaaaaatatgacttacatctCcagcaaaggtatgaaaatat	19	10	6	6	0	1	2	0	2	1	0	2	3	1	2	1	1	2	2	1	1	9	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:123346798C>T	uc003vkz.2	-	3	663	c.335G>A	c.(334-336)GGA>GAA	p.G112E		NM_003941	NP_003932	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome gene-like protein	112	WH1.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity				0						ACTTACATCTCCAGCAAAGGT	0.284													18	38					0	0	0	0	T	123346798	T	T	123346798	3	4	144	1	0	0	0	0	1	0	0	0	17324	855	30	2	1218	2	WASL	7	123346798	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	24262215	123346798	35791865	51	26332											
TMEM140	55281	broad.mit.edu	37	chr7	134849458	134849458	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggccaggcttggcgtgtacGggtccctggtcctcaccctc	3	10	13	15	2	1	0	1	0	0	0	4	0	3	0	4	5	1	2	4	5	1	2	rs143180494	by1000genomes	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:134849458G>A	uc003vsi.2	+	2	546	c.265G>A	c.(265-267)GGG>AGG	p.G89R	C7orf49_uc003vsh.2_Intron	NM_018295	NP_060765	Q9NV12	TM140_HUMAN	transmembrane protein 140	89	Helical; (Potential).					integral to membrane				large_intestine(1)	1						TGGCGTGTACGGGTCCCTGGT	0.652													38	69					0	0	0	0	A	134849458	A	A	134849458	3	1	144	1	0	0	0	0	1	0	0	0	16121	1116	39	1	267	1	TMEM140	7	134849458	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	11502660	134849458	24289205	52	26333											
TAF2	6873	broad.mit.edu	37	chr8	120818639	120818639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaaaaataattgaggtttCtcctggggaaaaaaaagagc	17	9	11	4	0	1	2	0	1	1	1	2	4	1	4	1	4	1	1	1	4	7	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr8:120818639C>T	uc003you.2	-	4	572	c.302G>A	c.(301-303)AGA>AAA	p.R101K		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	101					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATTGAGGTTTCTCCTGGGGAA	0.313													18	64					0	0	0	0	T	120818639	T	T	120818639	3	4	144	1	0	0	0	0	1	0	0	0	15590	913	32	2	3389	2	TAF2	8	120818639	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08		120818639	25545383	53	26334											
ZC3H3	23144	broad.mit.edu	37	chr8	144557590	144557590	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcgcaggaggggcctgctGcccgcatcactgggctggcc	4	6	17	14	2	1	0	1	0	0	0	1	1	1	1	3	5	3	4	3	5	0	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr8:144557590G>T	uc003yyd.2	-	5	1910	c.1881C>A	c.(1879-1881)GGC>GGA	p.G627G		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	627					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			GGGGCCTGCTGCCCGCATCAC	0.657													13	37					4.36969e-10	6.36132e-10	1	0	T	144557590	T	T	144557590	2	4	144	1	0	0	0	0	0	0	0	1	17636	1306	46	4		4	ZC3H3	8	144557590	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	23738951	144557590	1806432	54	26335											
TAF1L	138474	broad.mit.edu	37	chr9	32635389	32635389	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcccccaagcctgccaagtgCttcttacactcatcatccaa	10	9	5	17	0	3	0	2	0	1	0	4	0	4	0	5	0	4	1	5	0	4	2	rs55895024	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:32635389C>T	uc003zrg.1	-	1	279	c.189G>A	c.(187-189)AAG>AAA	p.K63K	uc003zrh.1_Intron	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	63					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CTGCCAAGTGCTTCTTACACT	0.547													35	134					0	0	0	0	T	32635389	T	T	32635389	2	4	144	1	0	0	0	0	0	0	0	1	15589	796	28	4		4	TAF1L	9	32635389	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08		32635389	108578042	55	26336											
UBE2R2	54926	broad.mit.edu	37	chr9	33917126	33917126	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttccaatgacaacagctCagatttgctttacgacgact	11	11	7	12	2	1	2	1	1	0	1	2	4	2	2	2	0	4	2	2	0	3	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:33917126C>G	uc003ztm.2	+	5	1182	c.608C>G	c.(607-609)TCA>TGA	p.S203*		NM_017811	NP_060281	Q712K3	UB2R2_HUMAN	ubiquitin-conjugating enzyme UBC3B	203	Asp/Glu-rich (acidic).				protein K48-linked ubiquitination|protein monoubiquitination		ATP binding|ubiquitin-protein ligase activity				0			LUSC - Lung squamous cell carcinoma(29;0.0176)	GBM - Glioblastoma multiforme(74;0.188)		GACAACAGCTCAGATTTGCTT	0.328													8	66					0	0	0	0	G	33917126	G	G	33917126	4	3	144	1	0	0	0	0	0	1	0	0	16939	838	29	2	626	2	UBE2R2	9	33917126	Nonsense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	1281737	33917126	107296305	56	26337											
ARID3C	138715	broad.mit.edu	37	chr9	34623560	34623560	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctgggtcctgagcgccccGagggggcggccctgccaagc	4	4	18	15	3	0	1	0	1	0	0	1	2	1	1	5	5	3	1	5	5	1	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:34623560G>A	uc011lon.1	-	4	727	c.727C>T	c.(727-729)CGG>TGG	p.R243W		NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	243	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		TGAGCGCCCCGAGGGGGCGGC	0.746													7	42					0	0	0	0	A	34623560	A	A	34623560	3	1	144	1	0	0	0	0	1	0	0	0	918	1057	37	1	526	1	ARID3C	9	34623560	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	706434	34623560	106589871	57	26338											
TLN1	7094	broad.mit.edu	37	chr9	35715166	35715166	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctgctgctcctcactgtCagggtgggcagctgctccct	3	11	12	15	0	2	0	2	0	0	0	4	0	4	0	2	2	5	6	2	2	0	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:35715166C>T	uc003zxt.2	-	21	2998	c.2644G>A	c.(2644-2646)GAC>AAC	p.D882N		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	882					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCCTCACTGTCAGGGTGGGCA	0.592													10	93					0	0	0	0	T	35715166	T	T	35715166	3	4	144	1	0	0	0	0	1	0	0	0	16013	826	29	2	5129	2	TLN1	9	35715166	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	1091606	35715166	105498265	58	26339											
C9orf135	138255	broad.mit.edu	37	chr9	72471558	72471558	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagcaaggctttattgaatGaggaaacagtgagctccggg	13	8	14	6	1	0	4	0	3	0	1	1	5	1	5	1	3	3	3	1	3	4	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:72471558G>A	uc004ahl.2	+	3	414	c.349G>A	c.(349-351)GAG>AAG	p.E117K	C9orf135_uc011lrw.1_Missense_Mutation_p.E9K|C9orf135_uc010moq.2_Missense_Mutation_p.E9K|C9orf135_uc011lrx.1_RNA|C9orf135_uc010mop.2_Missense_Mutation_p.E117K	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255	117	Extracellular (Potential).					integral to membrane				ovary(1)	1						TTTATTGAATGAGGAAACAGT	0.348													8	69					0	0	0	0	A	72471558	A	A	72471558	3	1	144	1	0	0	0	0	1	0	0	0	2470	1291	45	2	359	2	C9orf135	9	72471558	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	36756392	72471558	68741873	59	26340											
IARS	3376	broad.mit.edu	37	chr9	95043130	95043130	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactaaagatacagtttcatCttcttccaaagggaaagtta	16	12	6	7	0	3	1	1	0	2	1	4	2	4	2	1	1	2	2	1	1	7	6			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:95043130C>G	uc004art.1	-	7	900	c.643G>C	c.(643-645)GAT>CAT	p.D215H	IARS_uc004ars.1_Missense_Mutation_p.D60H|IARS_uc004aru.3_Missense_Mutation_p.D215H|IARS_uc010mqr.2_Missense_Mutation_p.D105H|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	215					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	ACAGTTTCATCTTCTTCCAAA	0.353													4	52					0	0	0	0	G	95043130	G	G	95043130	3	3	144	1	0	0	0	0	1	0	0	0	7512	913	32	2	3257	2	IARS	9	95043130	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	22571572	95043130	46170301	60	26341											
C5	727	broad.mit.edu	37	chr9	123731393	123731393	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttccgtagcctctgtagtggGatgctggcacataagacaag	10	10	12	9	1	1	1	0	0	1	1	2	2	2	2	2	2	2	4	2	2	4	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:123731393G>C	uc004bkv.2	-	33	4196	c.4166C>G	c.(4165-4167)TCC>TGC	p.S1389C		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1389					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TCTGTAGTGGGATGCTGGCAC	0.413													15	106					0	0	0	0	C	123731393	C	C	123731393	3	2	144	1	0	0	0	0	1	0	0	0	2290	1174	41	2	900	2	C5	9	123731393	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	28688263	123731393	17482038	61	26342											
TTLL11	158135	broad.mit.edu	37	chr9	124751422	124751422	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacacgaagccagagagcccTcttgaggccggtcaaggctg	10	6	13	12	2	2	2	1	1	1	1	2	4	2	2	3	3	3	1	3	3	3	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:124751422T>A	uc004blt.1	-	4	1779	c.1591A>T	c.(1591-1593)AGG>TGG	p.R531W	TTLL11_uc011lyl.1_Intron|TTLL11_uc004blr.2_Intron|TTLL11_uc011lym.1_Intron|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	531	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						CAGAGAGCCCTCTTGAGGCCG	0.547													29	113					0	0	0	0	A	124751422	A	A	124751422	3	1	144	1	0	0	0	0	1	0	0	0	16792	1550	54	5	913	5	TTLL11	9	124751422	Missense_Mutation	SNP	T	TCGA-CR-7373-01A-11D-2012-08	1020029	124751422	16462009	62	26343											
LRSAM1	90678	broad.mit.edu	37	chr9	130257620	130257620	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggagttagaagccaaaagtGaaaccaggcaggaaaattac	18	5	11	7	1	0	2	0	1	0	1	0	4	0	4	2	3	3	2	2	3	8	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:130257620G>A	uc004brb.1	+	22	1966	c.1621G>A	c.(1621-1623)GAA>AAA	p.E541K	LRSAM1_uc010mxk.1_Missense_Mutation_p.E514K|LRSAM1_uc004brc.1_Missense_Mutation_p.E541K|LRSAM1_uc004brd.1_Missense_Mutation_p.E541K|LRSAM1_uc004bre.1_Missense_Mutation_p.E121K|uc004brf.1_5'Flank|LRSAM1_uc004brg.1_5'UTR	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	541	Potential.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						AGCCAAAAGTGAAACCAGGCA	0.418													8	46					0	0	0	0	A	130257620	A	A	130257620	3	1	144	1	0	0	0	0	1	0	0	0	9093	1291	45	2	1699	2	LRSAM1	9	130257620	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	5506198	130257620	10955811	63	26344											
AK1	203	broad.mit.edu	37	chr9	130630646	130630646	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaggcgatgacaggttctGtggccttgtaataggtctcc	9	11	13	8	1	2	2	0	1	2	1	3	3	2	2	2	4	0	2	2	4	3	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:130630646G>A	uc004bsm.3	-	6	623	c.470C>T	c.(469-471)ACA>ATA	p.T157I		NM_000476	NP_000467	P00568	KAD1_HUMAN	adenylate kinase 1	157					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding				0						GACAGGTTCTGTGGCCTTGTA	0.532													10	17					0	0	0	0	A	130630646	A	A	130630646	3	1	144	1	0	0	0	0	1	0	0	0	439	1377	48	4	122	4	AK1	9	130630646	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	373026	130630646	10582785	64	26345											
BAT2L1	84726	broad.mit.edu	37	chr9	134321939	134321939	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gattctaaggacccctctctCcgcccggctcagcctgtccg	5	9	9	18	3	3	0	1	0	2	0	6	2	5	1	6	2	1	1	6	2	1	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:134321939C>T	uc004can.3	+	6	820	c.765C>T	c.(763-765)CTC>CTT	p.L255L	BAT2L1_uc010mzj.1_5'Flank|BAT2L1_uc004cam.1_Silent_p.L255L	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	255							protein binding				0						ACCCCTCTCTCCGCCCGGCTC	0.562													5	48					0	0	0	0	T	134321939	T	T	134321939	2	4	144	1	0	0	0	0	0	0	0	1	1322	842	30	2		2	BAT2L1	9	134321939	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	3691293	134321939	6891492	65	26346											
FAM69B	138311	broad.mit.edu	37	chr9	139617956	139617956	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacagcaccgactgcacctaCgggcgcgactgcagggcccc	8	3	12	18	4	0	0	0	0	0	0	0	2	0	0	4	2	4	3	4	2	1	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:139617956C>T	uc004cik.2	+	5	1120	c.1026C>T	c.(1024-1026)TAC>TAT	p.Y342Y	FAM69B_uc004cil.2_Silent_p.Y255Y|SNHG7_uc004cim.2_Intron	NM_152421	NP_689634	Q5VUD6	FA69B_HUMAN	hypothetical protein LOC138311	342	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.03e-05)|Epithelial(140;0.00013)		ACTGCACCTACGGGCGCGACT	0.687													8	13					0	0	0	0	T	139617956	T	T	139617956	2	4	144	1	0	0	0	0	0	0	0	1	5635	547	19	1		1	FAM69B	9	139617956	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	5296017	139617956	1595475	66	26347											
LYZL2	119180	broad.mit.edu	37	chr10	30900884	30900884	+	Nonstop_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcctgggtccagttccagtTtaggaaacctcacagtcttt	9	13	8	11	0	2	0	1	0	1	0	5	1	5	1	4	2	1	2	4	2	2	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:30900884T>A	uc001ivk.2	-	5	598	c.585A>T	c.(583-585)TAA>TAT	p.*195Y		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	195					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				CAGTTCCAGTTTAGGAAACCT	0.517													81	156					0	0	0	0	A	30900884	A	A	30900884	4	1	144	1	0	0	0	0	0	0	0	0	9183	1848	64	5	3	5	LYZL2	10	30900884	Nonstop_Mutation	SNP	T	TCGA-CR-7373-01A-11D-2012-08		30900884	104633863	67	26348											
ZNF438	220929	broad.mit.edu	37	chr10	31139092	31139092	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggccagcaacctgcatcaggGcatagttctgggtggacatc	9	8	13	11	0	2	0	1	0	1	0	3	1	2	1	2	4	3	4	2	4	2	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:31139092G>A	uc010qdz.1	-	7	677	c.242C>T	c.(241-243)GCC>GTC	p.A81V	ZNF438_uc001ivn.2_Missense_Mutation_p.A32V|ZNF438_uc010qdy.1_Missense_Mutation_p.A71V|ZNF438_uc001ivo.3_Intron|ZNF438_uc009xlg.2_Missense_Mutation_p.A81V|ZNF438_uc001ivp.3_Missense_Mutation_p.A71V|ZNF438_uc010qea.1_Missense_Mutation_p.A81V|ZNF438_uc010qeb.1_Missense_Mutation_p.A81V|ZNF438_uc010qec.1_Intron	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				CTGCATCAGGGCATAGTTCTG	0.532													4	116					0	0	0	0	A	31139092	A	A	31139092	3	1	144	1	0	0	0	0	1	0	0	0	17977	1203	42	4	2252	4	ZNF438	10	31139092	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	238208	31139092	104395655	68	26349											
ANKRD30A	91074	broad.mit.edu	37	chr10	37508040	37508040	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaggaaaataaatactttGaggacattaagattttaaaa	22	11	6	2	0	0	2	0	1	0	1	0	4	0	4	0	2	1	0	0	2	10	6			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:37508040G>A	uc001iza.1	+	34	3331	c.3232G>A	c.(3232-3234)GAG>AAG	p.E1078K		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1134	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TAAATACTTTGAGGACATTAA	0.338													48	88					0	0	0	0	A	37508040	A	A	37508040	3	1	144	1	0	0	0	0	1	0	0	0	658	1291	45	2	3366	2	ANKRD30A	10	37508040	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	6368948	37508040	98026707	69	26350											
CYP2C8	1558	broad.mit.edu	37	chr10	96818118	96818118	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cattttgatcaggaagcaatCgataaagtcccgaggattgt	13	11	10	7	2	1	1	1	1	0	0	3	5	2	3	1	2	1	1	1	2	4	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:96818118C>G	uc001kkb.2	-	5	888	c.793G>C	c.(793-795)GAT>CAT	p.D265H	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.D195H|CYP2C8_uc010qob.1_Missense_Mutation_p.D179H|CYP2C8_uc010qoc.1_Missense_Mutation_p.D163H|CYP2C8_uc010qod.1_Missense_Mutation_p.D179H	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	265					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	AGGAAGCAATCGATAAAGTCC	0.358													4	58					0	0	0	0	G	96818118	G	G	96818118	3	3	144	1	0	0	0	0	1	0	0	0	4184	884	31	3	699	3	CYP2C8	10	96818118	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	59310078	96818118	38716629	70	26351											
SLIT1	6585	broad.mit.edu	37	chr10	98770859	98770859	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggttctcactgcagttgtCacctgcataacctggcatgc	7	12	9	13	0	2	0	2	0	1	0	3	0	2	0	2	2	4	5	2	2	1	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:98770859C>T	uc001kmw.2	-	31	3484	c.3232G>A	c.(3232-3234)GAC>AAC	p.D1078N		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1078	EGF-like 4.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CTGCAGTTGTCACCTGCATAA	0.607													5	34					0	0	0	0	T	98770859	T	T	98770859	3	4	144	1	0	0	0	0	1	0	0	0	14803	826	29	2	1400	2	SLIT1	10	98770859	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	1952741	98770859	36763888	71	26352											
CCDC147	159686	broad.mit.edu	37	chr10	106113661	106113661	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagagagcatcaggatggcTgaggtcaggagtcagcgccc	10	5	15	11	1	3	2	3	1	0	1	3	5	3	4	2	4	2	2	2	4	0	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:106113661T>A	uc001kyh.2	+	1	140	c.6T>A	c.(4-6)GCT>GCA	p.A2A		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	2										ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		TCAGGATGGCTGAGGTCAGGA	0.597											OREG0020519	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	32					0	0	0	0	A	106113661	A	A	106113661	2	1	144	1	0	0	0	0	0	0	0	1	2793	1567	55	5		5	CCDC147	10	106113661	Silent	SNP	T	TCGA-CR-7373-01A-11D-2012-08	7342802	106113661	29421086	72	26353											
TACC2	10579	broad.mit.edu	37	chr10	123845099	123845099	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gatggttgttccccactctgGggcttgagtaagagggagat	8	11	15	7	0	1	3	0	1	1	2	2	5	2	3	2	4	0	4	2	4	1	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:123845099G>C	uc001lfv.2	+	4	3444	c.3084G>C	c.(3082-3084)TGG>TGC	p.W1028C	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.W1028C|TACC2_uc010qtv.1_Missense_Mutation_p.W1028C	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1028						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCCCACTCTGGGGCTTGAGTA	0.562													12	41					0	0	0	0	C	123845099	C	C	123845099	3	2	144	1	0	0	0	0	1	0	0	0	15568	1241	43	4	3094	4	TACC2	10	123845099	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	17731438	123845099	11689648	73	26354											
FAM53B	9679	broad.mit.edu	37	chr10	126311927	126311927	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgctctcctgccacaatcctCgtccagggcgcagctgtctg	5	9	10	17	3	2	0	0	0	2	0	6	0	4	0	4	1	2	3	4	1	1	0	rs140442850	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:126311927C>T	uc001lhv.1	-	5	1676	c.1153G>A	c.(1153-1155)GAG>AAG	p.E385K	FAM53B_uc001lhu.1_Intron	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	385										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		CCACAATCCTCGTCCAGGGCG	0.682													7	25					0	0	0	0	T	126311927	T	T	126311927	3	4	144	1	0	0	0	0	1	0	0	0	5612	893	31	1	119	1	FAM53B	10	126311927	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	2466828	126311927	9222820	74	26355											
SIRT3	23410	broad.mit.edu	37	chr11	233115	233115	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctccttggccaaagtgaaaaAgggcttggggttgtgaaaga	12	9	14	6	0	0	3	0	2	0	1	1	3	1	3	2	4	0	2	2	4	4	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:233115A>G	uc001lok.3	-	3	608	c.574T>C	c.(574-576)TTT>CTT	p.F192L	SIRT3_uc001loj.3_Missense_Mutation_p.F50L|SIRT3_uc010qvm.1_Missense_Mutation_p.F128L|SIRT3_uc010qvn.1_Missense_Mutation_p.F111L|SIRT3_uc010qvo.1_Missense_Mutation_p.F192L|SIRT3_uc010qvp.1_Missense_Mutation_p.F192L|SIRT3_uc010qvq.1_Missense_Mutation_p.F50L|SIRT3_uc009ybt.1_RNA	NM_012239	NP_036371	Q9NTG7	SIRT3_HUMAN	sirtuin 3 isoform a	192	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			urinary_tract(1)	1		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		AAAGTGAAAAAGGGCTTGGGG	0.547													3	61					0	0	0	0	G	233115	G	G	233115	3	3	144	1	0	0	0	0	1	0	0	0	14404	72	3	5	645	5	SIRT3	11	233115	Missense_Mutation	SNP	A	TCGA-CR-7373-01A-11D-2012-08		233115	134773401	75	26356											
MUC5B	727897	broad.mit.edu	37	chr11	1271273	1271273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctcctccactccggggaCgacctggatcctcacagagc	7	6	9	19	2	1	1	1	0	0	1	5	4	5	3	7	3	1	0	7	3	0	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:1271273C>T	uc009ycr.1	+	51	14708	c.14582C>T	c.(14581-14583)ACG>ATG	p.T4861M	MUC5B_uc001ltb.2_Missense_Mutation_p.T4391M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4388	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACTCCGGGGACGACCTGGATC	0.662													55	129					0	0	0	0	T	1271273	T	T	1271273	3	4	144	1	0	0	0	0	1	0	0	0	10032	536	19	1	13294	1	MUC5B	11	1271273	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	1038158	1271273	133735243	76	26357											
OR52H1	390067	broad.mit.edu	37	chr11	5566547	5566547	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggccagcatggagagaaaGaagaacatgggttcatgaag	16	6	14	5	0	1	4	1	1	0	3	1	6	1	5	1	3	2	2	1	3	4	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:5566547G>C	uc010qzh.1	-	1	207	c.207C>G	c.(205-207)TTC>TTG	p.F69L	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGAGAGAAAGAAGAACATGG	0.473													19	55					0	0	0	0	C	5566547	C	C	5566547	3	2	144	1	0	0	0	0	1	0	0	0	11173	933	33	2	758	2	OR52H1	11	5566547	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	4295274	5566547	129439969	77	26358											
OR10A2	341276	broad.mit.edu	37	chr11	6891450	6891450	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggctcttcagttttccattCtgtggcaccaacaaggtgaa	9	13	9	10	0	3	1	1	1	2	0	4	1	4	1	2	3	1	3	2	3	3	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:6891450C>T	uc001meu.1	+	1	465	c.465C>T	c.(463-465)TTC>TTT	p.F155F		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	155	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GTTTTCCATTCTGTGGCACCA	0.537													33	114					0	0	0	0	T	6891450	T	T	6891450	2	4	144	1	0	0	0	0	0	0	0	1	10944	912	32	2		2	OR10A2	11	6891450	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	1324903	6891450	128115066	78	26359											
SLC1A2	6506	broad.mit.edu	37	chr11	35308446	35308446	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatctagtcacacgcttatCaatccccagattttcttcca	11	13	4	13	1	4	1	2	0	2	1	6	2	6	1	3	0	0	1	3	0	4	5			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:35308446C>G	uc001mwd.2	-	8	1736	c.1144G>C	c.(1144-1146)GAT>CAT	p.D382H	SLC1A2_uc001mwe.2_Missense_Mutation_p.D373H|SLC1A2_uc010rev.1_Missense_Mutation_p.D382H	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	382					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	ACACGCTTATCAATCCCCAGA	0.458													39	124					0	0	0	0	G	35308446	G	G	35308446	3	3	144	1	0	0	0	0	1	0	0	0	14497	826	29	2	596	2	SLC1A2	11	35308446	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	28416996	35308446	99698070	79	26360											
MS4A2	2206	broad.mit.edu	37	chr11	59857261	59857261	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaccactgcatacatggctGacagttttgaaaaaagagca	15	8	8	10	0	0	3	0	2	0	1	0	3	0	3	2	1	3	4	2	1	4	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:59857261G>A	uc001nop.2	+	2	255	c.153G>A	c.(151-153)CTG>CTA	p.L51L	MS4A2_uc009ymu.2_Silent_p.L51L	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	51	Cytoplasmic (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	ATACATGGCTGACAGTTTTGA	0.468													23	44					0	0	0	0	A	59857261	A	A	59857261	2	1	144	1	0	0	0	0	0	0	0	1	9913	1277	45	2		2	MS4A2	11	59857261	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	24548815	59857261	75149255	80	26361											
C11orf51	25906	broad.mit.edu	37	chr11	71822259	71822259	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctcttccacacagggtcGatccagattaaaccacagag	12	9	8	12	1	1	2	0	0	1	2	5	3	3	2	3	1	1	0	3	1	2	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:71822259G>T	uc001orw.2	-	3	286	c.64C>A	c.(64-66)CGA>AGA	p.R22R	C11orf51_uc009ytc.1_Intron|C11orf51_uc001orv.2_Silent_p.R22R	NM_014042	NP_054761	P60006	CK051_HUMAN	hypothetical protein LOC25906	22						intracellular					0						ACACAGGGTCGATCCAGATTA	0.542													37	67					2.42023e-17	3.57193e-17	1	0	T	71822259	T	T	71822259	2	4	144	1	0	0	0	0	0	0	0	1	1652	1066	37	3		3	C11orf51	11	71822259	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	11964998	71822259	63184257	81	26362											
CCDC83	220047	broad.mit.edu	37	chr11	85597249	85597249	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttattttcaacagatatgcGcatgcaaataagtaatgctg	14	14	7	6	1	1	1	1	0	0	1	1	1	1	1	0	0	4	4	0	0	6	7			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:85597249G>A	uc001pbh.1	+	5	862	c.350G>A	c.(349-351)CGC>CAC	p.R117H	CCDC83_uc001pbg.1_Missense_Mutation_p.R117H|CCDC83_uc001pbi.1_RNA|CCDC83_uc001pbj.1_Intron	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	117	Potential.									skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				ACAGATATGCGCATGCAAATA	0.333													6	15					0	0	0	0	A	85597249	A	A	85597249	3	1	144	1	0	0	0	0	1	0	0	0	2870	1087	38	1	364	1	CCDC83	11	85597249	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	13774990	85597249	49409267	82	26363											
GPR83	10888	broad.mit.edu	37	chr11	94134045	94134045	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaaagtgaagggggtgttGagcagcgtgatcattatgtc	11	10	14	6	1	1	3	1	3	0	0	2	3	1	3	1	2	2	2	1	2	3	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:94134045G>C	uc001pet.2	-	1	541	c.369C>G	c.(367-369)CTC>CTG	p.L123L		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	123	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AGGGGGTGTTGAGCAGCGTGA	0.438													12	28					0	0	0	0	C	94134045	C	C	94134045	2	2	144	1	0	0	0	0	0	0	0	1	6751	1277	45	2		2	GPR83	11	94134045	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	8536796	94134045	40872471	83	26364											
ROBO3	64221	broad.mit.edu	37	chr11	124750348	124750348	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccatacagcagaccaagcttCctgtcccggggccagggcac	9	5	11	16	1	0	1	0	0	0	1	2	1	2	1	5	3	3	3	5	3	2	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:124750348C>T	uc001qbc.2	+	27	4185	c.3993C>T	c.(3991-3993)TTC>TTT	p.F1331F	ROBO3_uc001qbd.2_Silent_p.F256F|ROBO3_uc010sar.1_Silent_p.F380F|ROBO3_uc001qbe.2_Silent_p.F256F|ROBO3_uc001qbf.1_Silent_p.F215F	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	1331	Cytoplasmic (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GACCAAGCTTCCTGTCCCGGG	0.622													10	17					0	0	0	0	T	124750348	T	T	124750348	2	4	144	1	0	0	0	0	0	0	0	1	13580	854	30	2		2	ROBO3	11	124750348	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	30616303	124750348	10256168	84	26365											
ARHGAP32	9743	broad.mit.edu	37	chr11	128838895	128838895	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgtagcataggtcctgctCtgtggatggggaaagccagg	8	9	16	8	0	1	0	0	0	1	0	2	2	2	2	2	5	3	4	2	5	3	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:128838895C>G	uc009zcp.2	-	22	6171	c.6171G>C	c.(6169-6171)CAG>CAC	p.Q2057H	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.Q1016H|ARHGAP32_uc001qez.2_Missense_Mutation_p.Q1708H	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	2057	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						AGGTCCTGCTCTGTGGATGGG	0.587													7	25					0	0	0	0	G	128838895	G	G	128838895	3	3	144	1	0	0	0	0	1	0	0	0	881	912	32	2	96	2	ARHGAP32	11	128838895	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	4088547	128838895	6167621	85	26366											
IGSF9B	22997	broad.mit.edu	37	chr11	133792107	133792107	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcctgcagtgggtgatggaGagtggagggtctggaaggaa	9	9	19	4	0	1	2	0	1	1	1	2	6	2	5	1	6	1	1	1	6	2	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:133792107G>C	uc001qgx.3	-	17	2523	c.2292C>G	c.(2290-2292)CTC>CTG	p.L764L		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	764	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GGGTGATGGAGAGTGGAGGGT	0.602													4	16					0	0	0	0	C	133792107	C	C	133792107	2	2	144	1	0	0	0	0	0	0	0	1	7645	929	33	2		2	IGSF9B	11	133792107	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	4953212	133792107	1214409	86	26367											
CCND2	894	broad.mit.edu	37	chr12	4409145	4409145	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaactggaccaagccagcacCcctacagacgtgcgggatat	12	5	11	13	2	0	1	0	0	0	1	0	4	0	3	4	2	5	1	4	2	4	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:4409145C>T	uc001qmo.2	+	5	1145	c.840C>T	c.(838-840)ACC>ACT	p.T280T		NM_001759	NP_001750	P30279	CCND2_HUMAN	cyclin D2	280					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|breast(1)|kidney(1)	3			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			AAGCCAGCACCCCTACAGACG	0.547			T	IGL@	NHL,CLL								3	29					0	0	0	0	T	4409145	T	T	4409145	2	4	144	1	0	0	0	0	0	0	0	1	2932	610	22	4		4	CCND2	12	4409145	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08		4409145	129442750	87	26368											
GRIN2B	2904	broad.mit.edu	37	chr12	13722780	13722780	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaccatctccaaagagctgCaggatagcaaggtccacctg	12	7	9	13	0	2	1	1	0	1	1	4	2	3	2	4	2	3	3	4	2	3	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:13722780C>A	uc001rbt.2	-	11	2522	c.2343G>T	c.(2341-2343)CTG>CTT	p.L781L		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	781	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CAAAGAGCTGCAGGATAGCAA	0.488													18	46					1.33834e-09	1.93516e-09	1	0	A	13722780	A	A	13722780	2	1	144	1	0	0	0	0	0	0	0	1	6819	697	25	4		4	GRIN2B	12	13722780	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	9313635	13722780	120129115	88	26369											
MBD6	114785	broad.mit.edu	37	chr12	57920934	57920934	+	Frame_Shift_Del	DEL	C	-	-																															acttttccccccactttcagCcccccctaccctcatagctt																										TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:57920934delC	uc001soj.1	+	7	2230	c.2006delC	c.(2005-2007)GCCfs	p.A669fs	MBD6_uc001sok.1_Frame_Shift_Del_p.A536fs|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	669	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCACTTTCAGCCCCCCCTACC	0.642													---	---	---								-	57920934	-	-	57920934	7	5	144	1	0	1	0	1	0	0	0	0	9401	739	26	0	2024	0	MBD6	12	57920934	Frame_Shift_Del	DEL	C	TCGA-CR-7373-01A-11D-2012-08	44198154	57920934	75930961	89	26370											
TBX5	6910	broad.mit.edu	37	chr12	114804166	114804166	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggccactttttgcctcacGgtgctcctggggaccacggg	5	9	14	13	2	1	0	1	0	0	0	2	2	2	1	4	5	2	1	4	5	0	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:114804166G>C	uc001tvo.2	-	8	1281	c.786C>G	c.(784-786)ACC>ACG	p.T262T	TBX5_uc001tvp.2_Silent_p.T262T|TBX5_uc001tvq.2_Silent_p.T212T|TBX5_uc010syv.1_Silent_p.T262T	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	262					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TTTGCCTCACGGTGCTCCTGG	0.512													4	88					0	0	0	0	C	114804166	C	C	114804166	2	2	144	1	0	0	0	0	0	0	0	1	15727	1103	39	3		3	TBX5	12	114804166	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	56883232	114804166	19047729	90	26371											
RNF10	9921	broad.mit.edu	37	chr12	120972767	120972767	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccggcgagtctaaacccaaGagcggtaaggacgggcctgc	10	4	15	12	4	1	1	0	0	1	1	1	3	1	2	3	4	3	1	3	4	4	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:120972767G>C	uc001typ.3	+	1	636	c.153G>C	c.(151-153)AAG>AAC	p.K51N	RNF10_uc010szk.1_RNA	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	51	Ser-rich.				negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTAAACCCAAGAGCGGTAAGG	0.701													8	26					0	0	0	0	C	120972767	C	C	120972767	3	2	144	1	0	0	0	0	1	0	0	0	13487	933	33	2	155	2	RNF10	12	120972767	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	6168601	120972767	12879128	91	26372											
ORAI1	84876	broad.mit.edu	37	chr12	122079382	122079382	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaccatcatggtgcccttcGgcctgatctttatcgtcttc	5	14	7	15	2	3	1	1	1	2	0	6	1	3	1	4	2	1	0	4	2	1	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:122079382G>A	uc010szz.1	+	3	932	c.739G>A	c.(739-741)GGC>AGC	p.G247S		NM_032790	NP_116179	Q96D31	CRCM1_HUMAN	calcium release-activated calcium channel	247	Helical; (Potential).				platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		GGTGCCCTTCGGCCTGATCTT	0.627													28	56					0	0	0	0	A	122079382	A	A	122079382	3	1	144	1	0	0	0	0	1	0	0	0	11311	1116	39	1	751	1	ORAI1	12	122079382	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	1106615	122079382	11772513	92	26373											
MYCBP2	23077	broad.mit.edu	37	chr13	77715011	77715011	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaggttcagactttggtttGaccaactgagttcctggtgg	7	14	13	7	0	1	4	1	3	0	1	2	4	2	4	2	4	1	3	2	4	1	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr13:77715011G>C	uc001vkf.2	-	51	7348	c.7257C>G	c.(7255-7257)GTC>GTG	p.V2419V	MYCBP2_uc010aev.2_Silent_p.V1823V	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACTTTGGTTTGACCAACTGAG	0.408													66	179					0	0	0	0	C	77715011	C	C	77715011	2	2	144	1	0	0	0	0	0	0	0	1	10071	1277	45	2		2	MYCBP2	13	77715011	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08		77715011	37454867	93	26374											
OR4K2	390431	broad.mit.edu	37	chr14	20345329	20345329	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagatagccatgaggaaactGaaaaataggtttctaaattt	18	11	8	4	0	1	3	0	2	1	1	1	4	1	4	1	2	2	1	1	2	8	5			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr14:20345329G>C	uc001vwh.1	+	1	903	c.903G>C	c.(901-903)CTG>CTC	p.L301L		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGAGGAAACTGAAAAATAGGT	0.348													20	20					0	0	0	0	C	20345329	C	C	20345329	2	2	144	1	0	0	0	0	0	0	0	1	11126	1277	45	2		2	OR4K2	14	20345329	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08		20345329	87004211	94	26375											
RALGAPA1	253959	broad.mit.edu	37	chr14	36097115	36097115	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagatgtgtaataacagtgCgggctgctatagagattaat	13	11	11	6	1	0	2	0	0	0	2	0	3	0	2	1	1	3	3	1	1	5	5			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr14:36097115C>T	uc001wti.2	-	33	4911	c.4520G>A	c.(4519-4521)CGC>CAC	p.R1507H	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.R1507H|RALGAPA1_uc010tpv.1_Missense_Mutation_p.R1520H|RALGAPA1_uc010tpw.1_Missense_Mutation_p.R1554H	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1507	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						AATAACAGTGCGGGCTGCTAT	0.398													45	35					0	0	0	0	T	36097115	T	T	36097115	3	4	144	1	0	0	0	0	1	0	0	0	13078	768	27	1	1775	1	RALGAPA1	14	36097115	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	15751786	36097115	71252425	95	26376											
TJP1	7082	broad.mit.edu	37	chr15	30011032	30011032	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagagtgctgattatcaaaaGgtggccgagatgggtagggc	11	8	17	5	1	1	3	1	1	0	2	1	5	1	3	1	4	1	2	1	4	4	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:30011032G>C	uc001zcr.2	-	21	3789	c.3314C>G	c.(3313-3315)CCT>CGT	p.P1105R	TJP1_uc010azl.2_Missense_Mutation_p.P1093R|TJP1_uc001zcq.2_Missense_Mutation_p.P1029R|TJP1_uc001zcs.2_Missense_Mutation_p.P1025R	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1105					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		ATTATCAAAAGGTGGCCGAGA	0.493													4	162					0	0	0	0	C	30011032	C	C	30011032	3	2	144	1	0	0	0	0	1	0	0	0	15995	1000	35	4	1964	4	TJP1	15	30011032	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08		30011032	72520360	96	26377											
EHD4	30844	broad.mit.edu	37	chr15	42192864	42192864	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcggccttgggcagggaCttcctgtgcgaggggggcac	5	7	18	11	2	0	0	0	0	0	0	2	2	1	1	2	6	1	2	2	6	0	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:42192864C>A	uc001zot.2	-	6	1668	c.1605G>T	c.(1603-1605)AAG>AAT	p.K535N		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	535	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		TGGGCAGGGACTTCCTGTGCG	0.453													11	10					3.86212e-05	5.40192e-05	1	0	A	42192864	A	A	42192864	3	1	144	1	0	0	0	0	1	0	0	0	5002	564	20	4	24	4	EHD4	15	42192864	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	12181832	42192864	60338528	97	26378											
SH3GL3	6457	broad.mit.edu	37	chr15	84286874	84286874	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagccctgctgtcgtggtctCtatgactttgagccagaaaa	9	11	10	11	1	1	3	0	2	1	1	3	3	1	3	2	1	3	1	2	1	3	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:84286874C>G	uc002bjw.2	+	9	1074	c.879C>G	c.(877-879)CTC>CTG	p.L293L	SH3GL3_uc002bjx.2_Silent_p.L224L|SH3GL3_uc002bju.2_Silent_p.L301L|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	293	SH3.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						GTCGTGGTCTCTATGACTTTG	0.398													20	49					0	0	0	0	G	84286874	G	G	84286874	2	3	144	1	0	0	0	0	0	0	0	1	14317	900	32	2		2	SH3GL3	15	84286874	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	42094010	84286874	18244518	98	26379											
PDE8A	5151	broad.mit.edu	37	chr15	85669605	85669605	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcggaagaatatttttctcaGgtaagttgctgcctctttta	9	17	8	7	1	2	1	1	0	2	1	4	2	2	2	1	2	2	3	1	2	5	7			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:85669605G>A	uc002blh.2	+	20	2442	c.2253G>A	c.(2251-2253)CAG>CAA	p.Q751Q	PDE8A_uc002bli.2_Silent_p.Q705Q|PDE8A_uc010bnc.2_Silent_p.Q504Q|PDE8A_uc010bnd.2_Silent_p.Q504Q|PDE8A_uc002blj.2_Silent_p.Q371Q|PDE8A_uc002blk.2_Silent_p.Q371Q|PDE8A_uc002bll.2_Silent_p.Q103Q	NM_002605	NP_002596	O60658	PDE8A_HUMAN	phosphodiesterase 8A isoform 1	751	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			ATTTTTCTCAGGTAAGTTGCT	0.413													18	58					0	0	0	0	A	85669605	A	A	85669605	2	1	144	1	0	0	0	0	0	0	0	1	11707	1014	35	4		4	PDE8A	15	85669605	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	1382731	85669605	16861787	99	26380											
AGBL1	123624	broad.mit.edu	37	chr15	86687068	86687068	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccggctgctggccaaagttgGcctaagaggtactcgtactc	8	9	12	12	2	0	1	0	0	0	1	2	1	0	1	3	4	3	5	3	4	4	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:86687068G>A	uc002blz.1	+	2	196	c.116G>A	c.(115-117)GGC>GAC	p.G39D		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	39					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GCCAAAGTTGGCCTAAGAGGT	0.522													17	39					0	0	0	0	A	86687068	A	A	86687068	3	1	144	1	0	0	0	0	1	0	0	0	375	1203	42	4	118	4	AGBL1	15	86687068	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	1017463	86687068	15844324	100	26381											
C15orf42	90381	broad.mit.edu	37	chr15	90143870	90143870	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taaaaactagtaaaagtcttCgacagaatctaggaaaaaaa	22	8	6	5	1	2	1	0	0	2	1	3	3	2	2	0	1	1	1	0	1	11	5			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:90143870C>T	uc002boe.2	+	9	2107	c.2107C>T	c.(2107-2109)CGA>TGA	p.R703*		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	703					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TAAAAGTCTTCGACAGAATCT	0.303													6	19					0	0	0	0	T	90143870	T	T	90143870	4	4	144	1	0	0	0	0	0	1	0	0	1802	876	31	1	2141	1	C15orf42	15	90143870	Nonsense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	3456802	90143870	12387522	101	26382											
PDIA2	64714	broad.mit.edu	37	chr16	335330	335330	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacgtctgccaagatcttcGcggccaggatcctcaaccac	10	7	9	15	3	3	2	1	0	2	2	5	3	4	3	4	2	2	0	4	2	2	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:335330G>A	uc002cgn.1	+	11	1922	c.814G>A	c.(814-816)GCG>ACG	p.A272T	PDIA2_uc010bqt.1_Missense_Mutation_p.A117T|PDIA2_uc002cgo.1_Missense_Mutation_p.A272T	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	272					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CAAGATCTTCGCGGCCAGGAT	0.642													11	40					0	0	0	0	A	335330	A	A	335330	3	1	144	1	0	0	0	0	1	0	0	0	11722	1087	38	1	836	1	PDIA2	16	335330	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08		335330	90019423	102	26383											
FBXL16	146330	broad.mit.edu	37	chr16	745785	745785	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgagatggccgcgatggcgtCgtcggccacgttgatgcagt	6	8	16	11	7	0	2	0	1	0	1	2	4	0	2	2	3	1	2	2	3	0	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:745785C>T	uc002cjc.2	-	4	975	c.772G>A	c.(772-774)GAC>AAC	p.D258N	FBXL16_uc002cja.2_5'Flank|FBXL16_uc002cjb.2_Missense_Mutation_p.D46N	NM_153350	NP_699181	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	258	LRR 1.										0		Hepatocellular(780;0.0218)				GCGATGGCGTCGTCGGCCACG	0.687													20	30					0	0	0	0	T	745785	T	T	745785	3	4	144	1	0	0	0	0	1	0	0	0	5744	884	31	1	683	1	FBXL16	16	745785	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	410455	745785	89608968	103	26384											
SH2B1	25970	broad.mit.edu	37	chr16	28883683	28883683	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagtgagacaaggcggggTgaatacgtcctcaccttcaa	12	7	12	10	2	2	3	2	2	0	2	3	4	3	3	2	3	1	0	2	3	4	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:28883683T>G	uc002dri.2	+	9	2125	c.1686T>G	c.(1684-1686)GGT>GGG	p.G562G	uc010vct.1_Intron|SH2B1_uc010vdc.1_Silent_p.G252G|SH2B1_uc002drj.2_Silent_p.G562G|SH2B1_uc002drk.2_Silent_p.G562G|SH2B1_uc002drl.2_Silent_p.G562G|SH2B1_uc010vdd.1_Silent_p.G226G|SH2B1_uc010vde.1_Silent_p.G562G|SH2B1_uc002drm.2_Silent_p.G562G	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	562	SH2.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						CAAGGCGGGGTGAATACGTCC	0.612													4	60					0	0	0	0	G	28883683	G	G	28883683	2	3	144	1	0	0	0	0	0	0	0	1	14292	1683	59	5		5	SH2B1	16	28883683	Silent	SNP	T	TCGA-CR-7373-01A-11D-2012-08	28137898	28883683	61471070	104	26385											
ATP2A1	487	broad.mit.edu	37	chr16	28906160	28906160	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggccaaaggtgtctatgaGaaggtcggcgaggccaccga	11	5	15	10	3	1	1	0	1	1	1	2	4	1	1	3	5	0	0	3	5	3	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:28906160G>A	uc002dro.1	+	12	1489	c.1305G>A	c.(1303-1305)GAG>GAA	p.E435E	uc010vct.1_Intron|ATP2A1_uc002drn.1_Silent_p.E435E|ATP2A1_uc002drp.1_Silent_p.E310E	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	435	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTGTCTATGAGAAGGTCGGCG	0.567													17	41					0	0	0	0	A	28906160	A	A	28906160	2	1	144	1	0	0	0	0	0	0	0	1	1138	933	33	2		2	ATP2A1	16	28906160	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	22477	28906160	61448593	105	26386											
ZNF668	79759	broad.mit.edu	37	chr16	31073297	31073297	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccaggtccgccggctgccGgaagtccttgccgcacttct	4	8	13	16	4	1	0	0	0	1	0	3	1	3	1	6	4	2	2	6	4	1	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:31073297G>A	uc010caf.2	-	3	1309	c.952C>T	c.(952-954)CGG>TGG	p.R318W	ZNF668_uc002eao.2_Missense_Mutation_p.R318W	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	318	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						GCCGGCTGCCGGAAGTCCTTG	0.662													10	34					0	0	0	0	A	31073297	A	A	31073297	3	1	144	1	0	0	0	0	1	0	0	0	18142	1115	39	1	911	1	ZNF668	16	31073297	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	2167137	31073297	59281456	106	26387											
TMCO7	79613	broad.mit.edu	37	chr16	69007962	69007962	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtcagacgtctatcctgaGaaaatcttgccggacttgtt	9	13	9	10	2	3	2	1	1	2	2	4	4	4	3	2	1	1	1	2	1	3	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:69007962G>C	uc002ewi.3	+	15	2745	c.2733G>C	c.(2731-2733)GAG>GAC	p.E911D		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	911						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		TCTATCCTGAGAAAATCTTGC	0.458													11	23					0	0	0	0	C	69007962	C	C	69007962	3	2	144	1	0	0	0	0	1	0	0	0	16067	933	33	2	2791	2	TMCO7	16	69007962	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	37934665	69007962	21346791	107	26388											
CTRB2	440387	broad.mit.edu	37	chr16	75238201	75238201	+	Frame_Shift_Del	DEL	A	-	-																															ctccgtccttctggcagaccAgggggcctccagagtcaccc																										TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:75238201delA	uc002fdr.2	-	7	683	c.650delT	c.(649-651)CTGfs	p.L217fs		NM_001025200	NP_001020371	Q6GPI1	CTRB2_HUMAN	chymotrypsin B2 precursor	217	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity				0						CTGGCAGACCAGGGGGCCTCC	0.657													---	---	---								-	75238201	-	-	75238201	7	5	144	1	0	1	0	1	0	0	0	0	4043	188	7	0	145	0	CTRB2	16	75238201	Frame_Shift_Del	DEL	A	TCGA-CR-7373-01A-11D-2012-08	6230239	75238201	15116552	108	26389											
MTHFSD	64779	broad.mit.edu	37	chr16	86580199	86580199	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcgacggatcccaccacaacTaaatccacgaggactctgga	13	5	9	14	3	1	0	0	0	1	0	3	5	3	3	3	3	1	0	3	3	3	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:86580199T>C	uc002fjn.2	-	5	459	c.408A>G	c.(406-408)TTA>TTG	p.L136L	MTHFSD_uc010voo.1_Silent_p.L116L|MTHFSD_uc002fjo.2_5'UTR|MTHFSD_uc002fjm.2_Silent_p.L135L|MTHFSD_uc010vop.1_5'UTR|MTHFSD_uc010voq.1_Silent_p.L135L|MTHFSD_uc010vor.1_Silent_p.L136L|MTHFSD_uc002fjp.2_Silent_p.L116L	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	136					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0						CCACCACAACTAAATCCACGA	0.537													3	101					0	0	0	0	C	86580199	C	C	86580199	2	2	144	1	0	0	0	0	0	0	0	1	9986	1519	53	5		5	MTHFSD	16	86580199	Silent	SNP	T	TCGA-CR-7373-01A-11D-2012-08	11341998	86580199	3774554	109	26390											
TRPV1	7442	broad.mit.edu	37	chr17	3475479	3475479	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacctgcagcagcttgcctGagcggaaggccttcctcatg	7	8	11	15	1	1	1	1	1	0	0	2	2	2	2	5	2	5	3	5	2	1	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:3475479G>A	uc010vrr.1	-	13	2695	c.2168C>T	c.(2167-2169)TCA>TTA	p.S723L	TRPV1_uc010vro.1_Missense_Mutation_p.S734L|TRPV1_uc010vrp.1_Missense_Mutation_p.S663L|TRPV1_uc010vrq.1_Missense_Mutation_p.S721L|TRPV1_uc010vrs.1_Missense_Mutation_p.S723L|TRPV1_uc010vrt.1_Missense_Mutation_p.S723L|TRPV1_uc010vru.1_Missense_Mutation_p.S723L	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,	723	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	CAGCTTGCCTGAGCGGAAGGC	0.592													7	22					0	0	0	0	A	3475479	A	A	3475479	3	1	144	1	0	0	0	0	1	0	0	0	16662	1294	45	2	363	2	TRPV1	17	3475479	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08		3475479	77719731	110	26391											
RNF167	26001	broad.mit.edu	37	chr17	4847869	4847869	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggagaccagtatgatgtCtgtgccatttgcctggatga	9	11	12	9	0	1	3	0	2	1	1	1	5	1	4	4	2	2	1	4	2	1	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:4847869C>T	uc002fzq.2	+	10	1103	c.687C>T	c.(685-687)GTC>GTT	p.V229V	RNF167_uc002fzr.2_Silent_p.V229V|RNF167_uc002fzs.2_Silent_p.V229V|RNF167_uc002fzt.2_Silent_p.V229V|RNF167_uc002fzu.2_Silent_p.V228V|RNF167_uc002fzv.2_Silent_p.V194V|RNF167_uc002fzx.2_Silent_p.V193V|RNF167_uc002fzy.2_Missense_Mutation_p.S3F	NM_015528	NP_056343	Q9H6Y7	RN167_HUMAN	ring finger protein 167 precursor	229					negative regulation of cell cycle|protein polyubiquitination	cytoplasm|endomembrane system|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						AGTATGATGTCTGTGCCATTT	0.517													20	84					0	0	0	0	T	4847869	T	T	4847869	2	4	144	1	0	0	0	0	0	0	0	1	13523	900	32	2		2	RNF167	17	4847869	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	1372390	4847869	76347341	111	26392											
USP6	9098	broad.mit.edu	37	chr17	5048764	5048764	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgttccatgggcagctaaGatctcaagtcaaatgcaaga	13	11	9	8	0	2	2	2	0	1	2	4	2	3	2	1	1	2	4	1	1	4	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:5048764G>A	uc002gau.1	+	27	4287	c.2057G>A	c.(2056-2058)AGA>AAA	p.R686K	USP6_uc002gav.1_Missense_Mutation_p.R686K|USP6_uc010ckz.1_Missense_Mutation_p.R369K	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	686					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						GGGCAGCTAAGATCTCAAGTC	0.373			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								19	47					0	0	0	0	A	5048764	A	A	5048764	3	1	144	1	0	0	0	0	1	0	0	0	17154	942	33	2	2127	2	USP6	17	5048764	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	200895	5048764	76146446	112	26393											
SREBF1	6720	broad.mit.edu	37	chr17	17720296	17720297	+	Frame_Shift_Ins	INS	-	TT	TT																															ccaggtccaggtcagcctgcINSttgcgatgcctccagaagta																										TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:17720296_17720297insTT	uc002gru.1	-	9	1954_1955	c.1760_1761insAA	c.(1759-1761)AAGfs	p.K587fs	SREBF1_uc002grp.1_Frame_Shift_Ins_p.K206fs|SREBF1_uc002grq.1_Frame_Shift_Ins_p.K106fs|SREBF1_uc002grr.1_Frame_Shift_Ins_p.K333fs|SREBF1_uc002grs.1_Frame_Shift_Ins_p.K563fs|SREBF1_uc002grt.1_Frame_Shift_Ins_p.K617fs	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	587	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						GGTCAGCCTGCTTGCGATGCCT	0.653													---	---	---								TT	17720297	TT	TT	17720296	7	5	144	1	0	1	1	0	0	0	0	0	15207	796	28	0	1726	0	SREBF1	17	17720296	Frame_Shift_Ins	INS	-	TCGA-CR-7373-01A-11D-2012-08	12671532	17720296	63474914	113	26394											
LLGL1	3996	broad.mit.edu	37	chr17	18144788	18144788	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcacactgcccaaggtgagCgcgaagaccaagttcaagct	12	7	10	12	2	2	2	2	1	0	1	2	3	2	2	2	1	3	2	2	1	4	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:18144788C>T	uc002gsp.2	+	18	2587	c.2526C>T	c.(2524-2526)AGC>AGT	p.S842S		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	842	WD 12.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					CCAAGGTGAGCGCGAAGACCA	0.632													11	29					0	0	0	0	T	18144788	T	T	18144788	2	4	144	1	0	0	0	0	0	0	0	1	8875	767	27	1		1	LLGL1	17	18144788	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	424492	18144788	63050422	114	26395											
SHMT1	6470	broad.mit.edu	37	chr17	18244076	18244076	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcttcgggtggaagaggcGtgcgttctcctccagctggt	5	10	15	11	3	1	1	0	0	1	1	4	2	2	2	2	4	3	3	2	4	1	2	rs148701087	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:18244076G>A	uc002gta.2	-	6	761	c.571C>T	c.(571-573)CGC>TGC	p.R191C	SHMT1_uc002gsz.2_Translation_Start_Site|SHMT1_uc002gtb.2_Missense_Mutation_p.R191C|SHMT1_uc010cqb.2_Missense_Mutation_p.R191C|SHMT1_uc010vxt.1_Missense_Mutation_p.R53C|SHMT1_uc002gtd.1_Missense_Mutation_p.R191C|SHMT1_uc010vxu.1_Missense_Mutation_p.R191C	NM_004169	NP_004160	P34896	GLYC_HUMAN	serine hydroxymethyltransferase 1 (soluble)	191					carnitine biosynthetic process|folic acid metabolic process|L-serine catabolic process|one-carbon metabolic process|purine base biosynthetic process	cytosol|nucleus	glycine hydroxymethyltransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					Glycine(DB00145)|Mimosine(DB01055)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	TGGAAGAGGCGTGCGTTCTCC	0.557													5	12					0	0	0	0	A	18244076	A	A	18244076	3	1	144	1	0	0	0	0	1	0	0	0	14350	1145	40	1	908	1	SHMT1	17	18244076	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	99288	18244076	62951134	115	26396											
MED1	5469	broad.mit.edu	37	chr17	37576168	37576168	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagtgctgctgaccaggaaGagcctgggcaaaaagaacag	14	4	14	9	0	0	3	0	1	0	2	0	4	0	4	2	2	4	4	2	2	4	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:37576168G>C	uc002hrv.3	-	14	1311	c.1099C>G	c.(1099-1101)CTT>GTT	p.L367V	MED1_uc010wee.1_Missense_Mutation_p.L195V|MED1_uc002hru.2_Missense_Mutation_p.L367V	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	367	Interaction with ESR1.|Interaction with the Mediator complex.|Interaction with the Mediator complex and THRA.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TGACCAGGAAGAGCCTGGGCA	0.433										HNSCC(31;0.082)			23	36					0	0	0	0	C	37576168	C	C	37576168	3	2	144	1	0	0	0	0	1	0	0	0	9478	942	33	2	3662	2	MED1	17	37576168	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	19332092	37576168	43619042	116	26397											
SMARCE1	6605	broad.mit.edu	37	chr17	38785063	38785063	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttctcatcttctggtaTgggatctgttggtggctcct	3	20	10	8	0	4	0	1	0	4	0	6	1	5	1	1	4	0	3	1	4	1	6			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:38785063T>C	uc002hux.2	-	11	1334	c.1210A>G	c.(1210-1212)ATA>GTA	p.I404V	SMARCE1_uc010wff.1_3'UTR|SMARCE1_uc010wfg.1_3'UTR|SMARCE1_uc002huy.2_Missense_Mutation_p.I369V|SMARCE1_uc010wfh.1_Missense_Mutation_p.I334V|SMARCE1_uc010wfi.1_Missense_Mutation_p.I386V	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	404	Glu-rich.				chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)				TCTTCTGGTATGGGATCTGTT	0.418													64	131					0	0	0	0	C	38785063	C	C	38785063	3	2	144	1	0	0	0	0	1	0	0	0	14844	1464	51	5	29	5	SMARCE1	17	38785063	Missense_Mutation	SNP	T	TCGA-CR-7373-01A-11D-2012-08	1208895	38785063	42410147	117	26398											
FZD2	2535	broad.mit.edu	37	chr17	42635585	42635585	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgggactgcagccgggtgccGggggcaccccgggtggcccg	3	3	20	15	5	0	0	0	0	0	0	0	1	0	1	5	6	3	2	5	6	0	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:42635585G>A	uc002igx.1	+	1	661	c.529G>A	c.(529-531)GGG>AGG	p.G177R		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	177	Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		gccgggtgccgggggcacccc	0.418													5	13					0	0	0	0	A	42635585	A	A	42635585	3	1	144	1	0	0	0	0	1	0	0	0	6164	1116	39	1	531	1	FZD2	17	42635585	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	3850522	42635585	38559625	118	26399											
KIAA1267	284058	broad.mit.edu	37	chr17	44248386	44248386	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctccaattcttctgaaattGaattgcttttcagaaagttg	11	17	6	7	0	4	3	1	2	3	1	5	3	4	3	1	0	1	2	1	0	4	7	rs142696045	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:44248386G>C	uc002ikb.2	-	1	1209	c.1124C>G	c.(1123-1125)TCA>TGA	p.S375*	KIAA1267_uc002ikc.2_Nonsense_Mutation_p.S375*|KIAA1267_uc002ikd.2_Nonsense_Mutation_p.S375*|KIAA1267_uc010dav.2_Nonsense_Mutation_p.S375*	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	375						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				TTCTGAAATTGAATTGCTTTT	0.453													23	121					0	0	0	0	C	44248386	C	C	44248386	4	2	144	1	0	0	0	0	0	1	0	0	8258	1294	45	2	2249	2	KIAA1267	17	44248386	Nonsense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	1612801	44248386	36946824	119	26400											
RSAD1	55316	broad.mit.edu	37	chr17	48556334	48556334	+	Frame_Shift_Del	DEL	C	-	-																															cgtggagaacgcaggagggtCcccgagtcctgagcctgcgg																										TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:48556334delC	uc002iqw.1	+	1	145	c.89delC	c.(88-90)TCCfs	p.S30fs	RSAD1_uc010wmp.1_Frame_Shift_Del_p.S30fs|RSAD1_uc010wmq.1_RNA	NM_018346	NP_060816	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing	30					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GCAGGAGGGTCCCCGAGTCCT	0.776											OREG0024566	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	48556334	-	-	48556334	7	5	144	1	0	1	0	1	0	0	0	0	13759	855	30	0	91	0	RSAD1	17	48556334	Frame_Shift_Del	DEL	C	TCGA-CR-7373-01A-11D-2012-08	4307948	48556334	32638876	120	26401											
DGKE	8526	broad.mit.edu	37	chr17	54940147	54940147	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaagatataaaggcgactGaatagatggatgagggagtg	17	7	15	2	1	0	5	0	2	0	3	0	8	0	7	0	3	0	0	0	3	7	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:54940147G>T	uc002iur.2	+	12	1879	c.1699G>T	c.(1699-1701)GAA>TAA	p.E567*	DGKE_uc002ius.1_3'UTR	NM_003647	NP_003638	P52429	DGKE_HUMAN	diacylglycerol kinase epsilon	567					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)					AAAGGCGACTGAATAGATGGA	0.358													10	17					2.17888e-05	3.06763e-05	1	0	T	54940147	T	T	54940147	4	4	144	1	0	0	0	0	0	1	0	0	4490	1291	45	2	1741	2	DGKE	17	54940147	Nonsense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	6383813	54940147	26255063	121	26402											
ITGB4	3691	broad.mit.edu	37	chr17	73751885	73751885	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcaggagccgcggtgcgaGcggccgctgcagggctacag	6	4	19	12	5	0	0	0	0	0	0	0	2	0	1	2	5	5	4	2	5	1	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:73751885G>A	uc002jpg.2	+	35	4849	c.4662G>A	c.(4660-4662)GAG>GAA	p.E1554E	ITGB4_uc002jph.2_Silent_p.E1484E|ITGB4_uc002jpi.3_Silent_p.E1484E|ITGB4_uc002jpj.2_Silent_p.E1537E|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1554	Cytoplasmic (Potential).|Fibronectin type-III 3.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGCGGTGCGAGCGGCCGCTGC	0.701													11	25					0	0	0	0	A	73751885	A	A	73751885	2	1	144	1	0	0	0	0	0	0	0	1	7936	962	34	4		4	ITGB4	17	73751885	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	18811738	73751885	7443325	122	26403											
PQLC1	80148	broad.mit.edu	37	chr18	77710917	77710917	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caggagccagtccaggccctCggcctccatcgcagcgcccg	6	4	12	19	4	0	0	0	0	0	0	4	1	2	1	6	3	2	1	6	3	0	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr18:77710917C>G	uc002lnl.2	-	2	182	c.10G>C	c.(10-12)GAG>CAG	p.E4Q	PQLC1_uc010dre.2_5'UTR|PQLC1_uc002lnk.2_Missense_Mutation_p.E4Q|PQLC1_uc010xfm.1_Missense_Mutation_p.E4Q	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	4						integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		TCCAGGCCCTCGGCCTCCATC	0.766													3	6					0	0	0	0	G	77710917	G	G	77710917	3	3	144	1	0	0	0	0	1	0	0	0	12478	893	31	3	825	3	PQLC1	18	77710917	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08		77710917	366331	123	26404											
ZNRF4	148066	broad.mit.edu	37	chr19	5456154	5456154	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgttcgtgagcgaggccGcctcgcaggacctgcgggtc	5	7	16	13	5	0	1	0	1	0	0	3	3	0	2	3	3	2	2	3	3	0	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:5456154G>A	uc002mca.3	+	1	729	c.652G>A	c.(652-654)GCC>ACC	p.A218T		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	218	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GAGCGAGGCCGCCTCGCAGGA	0.672													34	74					0	0	0	0	A	5456154	A	A	5456154	3	1	144	1	0	0	0	0	1	0	0	0	18281	1087	38	1	654	1	ZNRF4	19	5456154	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08		5456154	53672829	124	26405											
SMARCA4	6597	broad.mit.edu	37	chr19	11132522	11132522	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgctgctgacgggcacacCgctgcagaacaagcttcccg	8	6	11	16	3	0	2	0	1	0	1	1	2	1	2	3	1	5	6	3	1	2	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:11132522C>T	uc002mqf.3	+	19	3022	c.2738C>T	c.(2737-2739)CCG>CTG	p.P913L	SMARCA4_uc010dxp.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxo.2_Missense_Mutation_p.P913L|SMARCA4_uc002mqg.1_Missense_Mutation_p.P913L|SMARCA4_uc010dxq.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxr.2_Missense_Mutation_p.P913L|SMARCA4_uc002mqj.3_Missense_Mutation_p.P913L|SMARCA4_uc010dxs.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxt.1_Missense_Mutation_p.P133L|SMARCA4_uc002mqh.3_Missense_Mutation_p.P36L|SMARCA4_uc002mqi.1_Missense_Mutation_p.P116L	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	913	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ACGGGCACACCGCTGCAGAAC	0.612			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				12	44					0	0	0	0	T	11132522	T	T	11132522	3	4	144	1	0	0	0	0	1	0	0	0	14834	652	23	1	2808	1	SMARCA4	19	11132522	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	5676368	11132522	47996461	125	26406											
NOTCH3	4854	broad.mit.edu	37	chr19	15290215	15290215	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagcagagatagcgggccacGaggtcaatgcatgaaccccc	12	4	13	12	2	1	2	1	1	0	1	1	5	1	2	3	2	4	2	3	2	3	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:15290215G>A	uc002nan.2	-	21	3496	c.3420C>T	c.(3418-3420)CTC>CTT	p.L1140L	NOTCH3_uc002nao.1_Silent_p.L1088L	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1140	Extracellular (Potential).|EGF-like 29; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			AGCGGGCCACGAGGTCAATGC	0.602													12	37					0	0	0	0	A	15290215	A	A	15290215	2	1	144	1	0	0	0	0	0	0	0	1	10604	1045	37	1		1	NOTCH3	19	15290215	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	4157693	15290215	43838768	126	26407											
CEACAM6	4680	broad.mit.edu	37	chr19	42260628	42260628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccacaacctgccccagaatcGtattggttacagctggtaca	11	9	8	13	1	0	1	0	0	0	1	1	1	0	1	4	2	5	4	4	2	5	4	rs145319104		TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:42260628G>A	uc002orm.2	+	2	334	c.185G>A	c.(184-186)CGT>CAT	p.R62H		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	62	Ig-like V-type.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		CCCCAGAATCGTATTGGTTAC	0.512													6	189					0	0	0	0	A	42260628	A	A	42260628	3	1	144	1	0	0	0	0	1	0	0	0	3211	1145	40	1	191	1	CEACAM6	19	42260628	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	26970413	42260628	16868355	127	26408											
RUVBL2	10856	broad.mit.edu	37	chr19	49507659	49507659	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccagccgggcacggggaaGacggccatcgccatgggtaa	9	3	17	12	4	0	1	0	0	0	1	1	2	0	2	4	6	1	2	4	6	2	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:49507659G>C	uc002plr.1	+	4	262	c.249G>C	c.(247-249)AAG>AAC	p.K83N	RUVBL2_uc002plq.1_Missense_Mutation_p.K38N|RUVBL2_uc010yab.1_Missense_Mutation_p.K83N|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Missense_Mutation_p.K38N|RUVBL2_uc010yac.1_Missense_Mutation_p.K38N	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	83	ATP.				cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		GCACGGGGAAGACGGCCATCG	0.537													14	60					0	0	0	0	C	49507659	C	C	49507659	3	2	144	1	0	0	0	0	1	0	0	0	13818	933	33	2	263	2	RUVBL2	19	49507659	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08	7247031	49507659	9621324	128	26409											
PRR12	57479	broad.mit.edu	37	chr19	50098966	50098966	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgggaccccaggcctacggGcaagggtttggaggggggca	7	5	19	10	1	0	0	0	0	0	0	0	2	0	2	3	8	1	3	3	8	2	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:50098966G>T	uc002poo.3	+	4	1374	c.1374G>T	c.(1372-1374)GGG>GGT	p.G458G		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	207	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		AGGCCTACGGGCAAGGGTTTG	0.711													7	20					0.00198382	0.00273895	1	0	T	50098966	T	T	50098966	2	4	144	1	0	0	0	0	0	0	0	1	12646	1190	42	4		4	PRR12	19	50098966	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08	591307	50098966	9030017	129	26410											
MYBPC2	4606	broad.mit.edu	37	chr19	50958903	50958903	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtactgcctggaaggctgTgagtgaccctggcagggctg	7	8	17	9	0	0	2	0	2	0	0	0	4	0	3	2	4	2	4	2	4	2	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:50958903T>C	uc002psf.2	+	20	2389	c.2338_splice	c.e20+2	p.S780_splice		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type						cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		TGGAAGGCTGTGAGTGACCCT	0.602													31	46					0	0	0	0	C	50958903	C	C	50958903	5	2	144	1	0	0	0	0	0	0	1	0	10065	1710	59	5	2418	5	MYBPC2	19	50958903	Splice_Site	SNP	T	TCGA-CR-7373-01A-11D-2012-08	859937	50958903	8170080	130	26411											
GGTLC1	92086	broad.mit.edu	37	chr20	23966391	23966391	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggcccacttcacgtcataGccgaaccagaggttgtagat	11	8	10	12	3	2	2	2	0	0	2	2	3	2	2	3	2	2	2	3	2	3	4			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:23966391G>A	uc002wts.2	-	5	577	c.444C>T	c.(442-444)GGC>GGT	p.G148G	GGTLC1_uc002wtu.2_Silent_p.G148G	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	148							gamma-glutamyltransferase activity			ovary(1)	1						TCACGTCATAGCCGAACCAGA	0.612													38	142					0	0	0	0	A	23966391	A	A	23966391	2	1	144	1	0	0	0	0	0	0	0	1	6402	958	34	4		4	GGTLC1	20	23966391	Silent	SNP	G	TCGA-CR-7373-01A-11D-2012-08		23966391	39059129	131	26412											
GGTLC1	92086	broad.mit.edu	37	chr20	23967230	23967230	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcccggagctgggcagAgaagaactcggaggtcatgt	9	6	17	9	2	1	2	1	0	0	2	2	5	1	4	1	5	2	2	1	5	2	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:23967230A>C	uc002wts.2	-	2	152	c.19T>G	c.(19-21)TCT>GCT	p.S7A	GGTLC1_uc002wtu.2_Missense_Mutation_p.S7A	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	7							gamma-glutamyltransferase activity			ovary(1)	1						AGCTGGGCAGAGAAGAACTCG	0.642													3	83					0	0	0	0	C	23967230	C	C	23967230	3	2	144	1	0	0	0	0	1	0	0	0	6402	304	11	5	678	5	GGTLC1	20	23967230	Missense_Mutation	SNP	A	TCGA-CR-7373-01A-11D-2012-08	839	23967230	39058290	132	26413											
RBL1	5933	broad.mit.edu	37	chr20	35695460	35695460	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgcattggcaaaaatcagAtccaagcagcatagaagtaa	18	7	8	8	1	1	2	1	0	0	2	3	2	2	2	1	1	2	5	1	1	6	3			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:35695460A>G	uc002xgi.2	-	5	700	c.621T>C	c.(619-621)GAT>GAC	p.D207D	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Silent_p.D207D|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	207					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				CAAAAATCAGATCCAAGCAGC	0.303													25	68					0	0	0	0	G	35695460	G	G	35695460	2	3	144	1	0	0	0	0	0	0	0	1	13174	330	12	5		5	RBL1	20	35695460	Silent	SNP	A	TCGA-CR-7373-01A-11D-2012-08	11728230	35695460	27330060	133	26414											
SEMG1	6406	broad.mit.edu	37	chr20	43837187	43837187	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacaaatagagaacaagacCtactcagtcatgaacaaaaa	21	6	5	9	0	2	3	2	1	0	2	2	4	2	3	1	0	4	0	1	0	9	3	rs145325570	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:43837187C>A	uc002xni.2	+	2	1306	c.1249C>A	c.(1249-1251)CTA>ATA	p.L417I	SEMG1_uc002xnj.2_Missense_Mutation_p.L357I|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.L357I	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	417	42 AA repeat 3.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				AGAACAAGACCTACTCAGTCA	0.438													21	48					4.96729e-08	7.13423e-08	1	0	A	43837187	A	A	43837187	3	1	144	1	0	0	0	0	1	0	0	0	14109	680	24	4	1255	4	SEMG1	20	43837187	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08	8141727	43837187	19188333	134	26415											
ZNF831	128611	broad.mit.edu	37	chr20	57768086	57768086	+	Frame_Shift_Del	DEL	T	-	-																															agcagggagctcaggcacagTccccacccaagacaggagga																										TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:57768086delT	uc002yan.2	+	1	2012	c.2012delT	c.(2011-2013)GTCfs	p.V671fs		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	671						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCAGGCACAGTCCCCACCCAA	0.622													---	---	---								-	57768086	-	-	57768086	7	5	144	1	0	1	0	1	0	0	0	0	18252	1667	58	0	2014	0	ZNF831	20	57768086	Frame_Shift_Del	DEL	T	TCGA-CR-7373-01A-11D-2012-08	13930899	57768086	5257434	135	26416											
DSCAM	1826	broad.mit.edu	37	chr21	41710050	41710050	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcacggtcacgtggacgctCtggctggtggagagttgtgg	5	11	17	8	3	3	1	2	0	1	1	3	3	3	2	0	6	0	3	0	6	0	2			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr21:41710050C>G	uc002yyq.1	-	8	2213	c.1761G>C	c.(1759-1761)CAG>CAC	p.Q587H	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	587	Extracellular (Potential).|Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CGTGGACGCTCTGGCTGGTGG	0.507													12	102					0	0	0	0	G	41710050	G	G	41710050	3	3	144	1	0	0	0	0	1	0	0	0	4790	912	32	2	4381	2	DSCAM	21	41710050	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08		41710050	6419845	136	26417											
LZTR1	8216	broad.mit.edu	37	chr22	21348988	21348988	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctggttgtgtgcgagagtgCcgcccggctgcagctgagcc	4	8	17	12	3	0	2	0	1	0	1	0	3	0	2	3	2	5	5	3	2	0	1			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr22:21348988C>T	uc002zto.2	+	15	1860	c.1757C>T	c.(1756-1758)GCC>GTC	p.A586V	LZTR1_uc002ztn.2_Missense_Mutation_p.A545V|LZTR1_uc011ahy.1_Missense_Mutation_p.A567V|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	586					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGCGAGAGTGCCGCCCGGCTG	0.657													3	31					0	0	0	0	T	21348988	T	T	21348988	3	4	144	1	0	0	0	0	1	0	0	0	9188	739	26	4	1815	4	LZTR1	22	21348988	Missense_Mutation	SNP	C	TCGA-CR-7373-01A-11D-2012-08		21348988	29955578	137	26418											
SYAP1	94056	broad.mit.edu	37	chrX	16737953	16737953	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccgtccgagacggtggctGagtctgcggaggaggagctg	7	6	19	9	4	1	2	0	1	1	1	2	6	2	5	2	5	3	2	2	5	0	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chrX:16737953G>C	uc004cxp.2	+	1	199	c.106G>C	c.(106-108)GAG>CAG	p.E36Q	SYAP1_uc004cxo.2_Missense_Mutation_p.E36Q|SYAP1_uc011miv.1_Silent_p.L14L	NM_032796	NP_116185	Q96A49	SYAP1_HUMAN	SYAP1 protein	36										skin(1)	1	Hepatocellular(33;0.0997)					GACGGTGGCTGAGTCTGCGGA	0.667													4	3					0	0	0	0	C	16737953	C	C	16737953	3	2	144	1	0	0	0	0	1	0	0	0	15492	1291	45	2	108	2	SYAP1	23	16737953	Missense_Mutation	SNP	G	TCGA-CR-7373-01A-11D-2012-08		16737953	138532607	138	26419											
SSX1	6756	broad.mit.edu	37	chrX	48123288	48123288	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaagcatctggcccacaaaaCgatgggaaacaactgcaccc	15	4	9	13	1	1	0	0	0	1	0	1	3	1	1	2	2	5	2	2	2	5	0			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chrX:48123288C>T	uc004djb.1	+	6	493	c.402C>T	c.(400-402)AAC>AAT	p.N134N		NM_005635	NP_005626	Q16384	SSX1_HUMAN	synovial sarcoma, X breakpoint 1	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|transcription corepressor activity		SS18/SSX1(1169)	soft_tissue(1169)	1169						GCCCACAAAACGATGGGAAAC	0.423													82	59					0	0	0	0	T	48123288	T	T	48123288	2	4	144	1	0	0	0	0	0	0	0	1	15269	535	19	1		1	SSX1	23	48123288	Silent	SNP	C	TCGA-CR-7373-01A-11D-2012-08	31385335	48123288	107147272	139	26420											
CASZ1	54897	broad.mit.edu	37	chr1	10713622	10713622	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggtgtgtcaggggtggctGaggctgctgacccagacgac	6	8	18	9	1	1	3	1	2	0	1	1	4	1	3	1	5	1	3	1	5	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:10713622G>C	uc001aro.2	-	11	2812	c.2492C>G	c.(2491-2493)TCA>TGA	p.S831*	CASZ1_uc001arp.1_Nonsense_Mutation_p.S831*|CASZ1_uc009vmx.2_Nonsense_Mutation_p.S855*	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	831					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		AGGGGTGGCTGAGGCTGCTGA	0.706													12	52					0	0	0	0	C	10713622	C	C	10713622	4	2	145	1	0	0	0	0	0	1	0	0	2697	1294	45	2	2835	2	CASZ1	1	10713622	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08		10713622	238536999	1	26421											
PDPN	10630	broad.mit.edu	37	chr1	13940214	13940214	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagacacacagacaacagttGagaaaggtaggctagatttt	16	8	11	6	0	0	4	0	1	0	4	0	6	0	4	0	2	1	3	0	2	4	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:13940214G>C	uc001avd.2	+	4	641	c.592G>C	c.(592-594)GAG>CAG	p.E198Q	PDPN_uc001avc.2_Missense_Mutation_p.E198Q|PDPN_uc009vob.2_Missense_Mutation_p.E80Q|PDPN_uc009voc.2_Missense_Mutation_p.E80Q|PDPN_uc001ave.2_Missense_Mutation_p.E80Q|PDPN_uc001avf.2_Missense_Mutation_p.E80Q	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	122	Extracellular (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		GACAACAGTTGAGAAAGGTAG	0.323													16	19					0	0	0	0	C	13940214	C	C	13940214	3	2	145	1	0	0	0	0	1	0	0	0	11742	1291	45	2	606	2	PDPN	1	13940214	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3226592	13940214	235310407	2	26422											
PUM1	9698	broad.mit.edu	37	chr1	31423055	31423055	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atctgtagtgccaatgacagGacgtggcctcgaatccgttc	9	10	11	11	3	1	1	0	1	1	0	4	3	2	2	3	2	1	2	3	2	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:31423055G>A	uc001bsi.1	-	17	2888	c.2775C>T	c.(2773-2775)GTC>GTT	p.V925V	PUM1_uc001bsf.1_Silent_p.V591V|PUM1_uc001bsg.1_Silent_p.V659V|PUM1_uc001bsh.1_Silent_p.V925V|PUM1_uc001bsj.1_Silent_p.V899V|PUM1_uc010oga.1_Silent_p.V781V|PUM1_uc001bsk.1_Silent_p.V961V|PUM1_uc010ogb.1_Silent_p.V866V|SNORD103A_uc009vts.1_5'Flank	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	925	PUM-HD.|Pumilio 3.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		CCAATGACAGGACGTGGCCTC	0.438													6	65					0	0	0	0	A	31423055	A	A	31423055	2	1	145	1	0	0	0	0	0	0	0	1	12890	1161	41	2		2	PUM1	1	31423055	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	17482841	31423055	217827566	3	26423											
TRIT1	54802	broad.mit.edu	37	chr1	40319737	40319737	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctcgggcaaatatatcttCaatgtgaacattaagaaaga	16	11	8	6	1	3	3	1	1	2	2	4	3	3	3	0	1	1	1	0	1	7	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:40319737C>T	uc010oiz.1	-	3	333	c.319G>A	c.(319-321)GAA>AAA	p.E107K	TRIT1_uc001cec.3_RNA|TRIT1_uc001ced.3_5'UTR|TRIT1_uc001cee.3_RNA|TRIT1_uc001cef.3_RNA|TRIT1_uc001ceg.3_5'UTR|TRIT1_uc001ceh.3_5'UTR|TRIT1_uc009vvv.2_5'UTR|TRIT1_uc001cei.3_5'UTR|TRIT1_uc001ceq.2_Intron|TRIT1_uc001cek.2_Intron|TRIT1_uc009vvx.2_Intron|TRIT1_uc001cel.2_Intron|TRIT1_uc001cem.2_Intron|TRIT1_uc001cen.2_Intron|TRIT1_uc001ceo.2_Intron|TRIT1_uc001cep.2_Intron|TRIT1_uc010oja.1_RNA	NM_017646	NP_060116	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1 precursor	107					tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AATATATCTTCAATGTGAACA	0.373													13	73					0	0	0	0	T	40319737	T	T	40319737	3	4	145	1	0	0	0	0	1	0	0	0	16627	840	29	2	1120	2	TRIT1	1	40319737	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	8896682	40319737	208930884	4	26424											
RIMS3	9783	broad.mit.edu	37	chr1	41107389	41107389	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgccccctcaccaggctgcGgaagctggagtgtgctcttg	6	9	13	13	1	2	0	1	0	1	0	2	2	2	2	3	3	4	3	3	3	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:41107389G>A	uc001cfu.1	-	3	678	c.209C>T	c.(208-210)CCG>CTG	p.P70L	RIMS3_uc001cfv.1_Missense_Mutation_p.P70L	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	70					neurotransmitter transport	cell junction|synapse					0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			ACCAGGCTGCGGAAGCTGGAG	0.637													15	92					0	0	0	0	A	41107389	A	A	41107389	3	1	145	1	0	0	0	0	1	0	0	0	13434	1116	39	1	741	1	RIMS3	1	41107389	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	787652	41107389	208143232	5	26425											
SLC5A9	200010	broad.mit.edu	37	chr1	48708177	48708177	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	actgccccctctctgagctgGagaaggaggcccacgagagc	9	5	13	14	1	1	3	0	1	1	2	2	6	1	4	3	3	3	1	3	3	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:48708177G>T	uc001cro.2	+	13	1778	c.1726G>T	c.(1726-1728)GAG>TAG	p.E576*	SLC5A9_uc001crn.2_Nonsense_Mutation_p.E601*|SLC5A9_uc010omt.1_Nonsense_Mutation_p.E590*|SLC5A9_uc001crp.2_Nonsense_Mutation_p.E243*|SLC5A9_uc010omu.1_Nonsense_Mutation_p.E243*|SLC5A9_uc009vyt.1_RNA	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	576	Cytoplasmic (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						CTCTGAGCTGGAGAAGGAGGC	0.622													6	170					0.00116845	0.00170388	1	0	T	48708177	T	T	48708177	4	4	145	1	0	0	0	0	0	1	0	0	14736	1175	41	2	1855	2	SLC5A9	1	48708177	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	7600788	48708177	200542444	6	26426											
ELAVL4	1996	broad.mit.edu	37	chr1	50661352	50661352	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccgattactgtgaagtttGccaacaaccccagccagaag	14	7	8	12	1	0	2	0	1	0	1	0	3	0	2	5	0	6	1	5	0	6	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:50661352G>T	uc001csb.2	+	5	896	c.628G>T	c.(628-630)GCC>TCC	p.A210S	ELAVL4_uc001cry.3_Missense_Mutation_p.A213S|ELAVL4_uc001crz.3_Missense_Mutation_p.A210S|ELAVL4_uc001csa.3_Missense_Mutation_p.A227S|ELAVL4_uc001csc.3_Missense_Mutation_p.A210S|ELAVL4_uc009vyu.2_Missense_Mutation_p.A215S|ELAVL4_uc010omz.1_Missense_Mutation_p.A215S	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	210	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						TGTGAAGTTTGCCAACAACCC	0.572													57	94					4.54978e-40	8.39599e-40	1	0	T	50661352	T	T	50661352	3	4	145	1	0	0	0	0	1	0	0	0	5076	1319	46	4	745	4	ELAVL4	1	50661352	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1953175	50661352	198589269	7	26427											
ORC1L	4998	broad.mit.edu	37	chr1	52854210	52854210	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctctccttggaaggggCggtgtggaagcctcttcttc	4	12	15	10	1	3	0	0	0	3	0	5	2	3	2	2	6	2	1	2	6	2	3	rs61756135		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:52854210C>T	uc001ctt.2	-	8	1506	c.1287G>A	c.(1285-1287)CCG>CCA	p.P429P	ORC1L_uc010oni.1_Silent_p.P429P|ORC1L_uc001ctu.2_Silent_p.P429P|ORC1L_uc009vzd.2_Silent_p.P183P	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	429					cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						TTGGAAGGGGCGGTGTGGAAG	0.483													8	180					0	0	0	0	T	52854210	T	T	52854210	2	4	145	1	0	0	0	0	0	0	0	1	11315	755	27	1		1	ORC1L	1	52854210	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2192858	52854210	196396411	8	26428											
FAM73A	374986	broad.mit.edu	37	chr1	78279429	78279429	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taatttttaggtatggaattGtttgaagaggcattgcgtcg	10	16	12	3	2	0	2	0	1	0	1	1	3	0	3	0	3	1	3	0	3	5	8			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:78279429G>A	uc001dhx.2	+	6	680	c.648G>A	c.(646-648)TTG>TTA	p.L216L	FAM73A_uc010ork.1_Silent_p.L216L|FAM73A_uc010orl.1_Silent_p.L178L|FAM73A_uc001dhy.1_Silent_p.L5L	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	216						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		GTATGGAATTGTTTGAAGAGG	0.388													45	50					0	0	0	0	A	78279429	A	A	78279429	2	1	145	1	0	0	0	0	0	0	0	1	5649	1368	48	4		4	FAM73A	1	78279429	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	25425219	78279429	170971192	9	26429											
MCOLN3	55283	broad.mit.edu	37	chr1	85498622	85498622	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatgtgaaaaggttcatctgGctccacaaagaaacactctg	15	9	8	9	0	3	2	1	1	2	1	4	2	4	2	1	2	1	2	1	2	5	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:85498622G>C	uc001dkp.2	-	5	661	c.568C>G	c.(568-570)CCA>GCA	p.P190A	MCOLN3_uc001dkq.2_Missense_Mutation_p.P134A|MCOLN3_uc001dkr.2_Missense_Mutation_p.P190A|MCOLN3_uc001dks.3_Missense_Mutation_p.P35A	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	190						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		GGTTCATCTGGCTCCACAAAG	0.398													110	126					0	0	0	0	C	85498622	C	C	85498622	3	2	145	1	0	0	0	0	1	0	0	0	9450	1203	42	4	1129	4	MCOLN3	1	85498622	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	7219193	85498622	163751999	10	26430											
CCDC18	343099	broad.mit.edu	37	chr1	93672782	93672782	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtattttgaagctagagagtGagttagagaacaaagacgaa	17	9	12	3	1	0	5	0	2	0	3	0	8	0	5	0	0	2	3	0	0	7	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:93672782G>C	uc001dpq.2	+	9	1558	c.1390G>C	c.(1390-1392)GAG>CAG	p.E464Q	CCDC18_uc009wdl.1_Missense_Mutation_p.E25Q	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	346	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		GCTAGAGAGTGAGTTAGAGAA	0.353													7	36					0	0	0	0	C	93672782	C	C	93672782	3	2	145	1	0	0	0	0	1	0	0	0	2807	1291	45	2	1424	2	CCDC18	1	93672782	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	8174160	93672782	155577839	11	26431											
AKNAD1	254268	broad.mit.edu	37	chr1	109369904	109369904	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agttgatccttccgtggcccTttttctccacgttttgcttc	3	18	7	13	2	1	1	0	1	1	0	5	1	3	1	4	1	1	3	4	1	0	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:109369904T>C	uc001dwa.2	-	11	2128	c.1859A>G	c.(1858-1860)AAG>AGG	p.K620R	AKNAD1_uc010ovb.1_Missense_Mutation_p.K327R|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	620										ovary(3)	3						TCCGTGGCCCTTTTTCTCCAC	0.413													4	219					0	0	0	0	C	109369904	C	C	109369904	3	2	145	1	0	0	0	0	1	0	0	0	464	1609	56	5	675	5	AKNAD1	1	109369904	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	15697122	109369904	139880717	12	26432											
WDR47	22911	broad.mit.edu	37	chr1	109538250	109538250	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaaaggtatgtgatttgttGatccaggattacgaggagtg	12	12	14	3	1	0	2	0	2	0	0	1	6	1	4	1	3	1	2	1	3	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:109538250G>C	uc001dwj.2	-	8	2019	c.1643C>G	c.(1642-1644)TCA>TGA	p.S548*	WDR47_uc001dwl.2_Nonsense_Mutation_p.S556*|WDR47_uc001dwi.2_Nonsense_Mutation_p.S549*|WDR47_uc001dwk.2_Nonsense_Mutation_p.S520*|WDR47_uc010ovf.1_Nonsense_Mutation_p.S475*	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	548										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		GTGATTTGTTGATCCAGGATT	0.373													37	235					0	0	0	0	C	109538250	C	C	109538250	4	2	145	1	0	0	0	0	0	1	0	0	17368	1294	45	2	1148	2	WDR47	1	109538250	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	168346	109538250	139712371	13	26433											
PTPN22	26191	broad.mit.edu	37	chr1	114397643	114397643	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catggtctggccaattcttgTaatgaaactggtagatagtt	11	14	10	6	0	2	2	0	1	2	1	2	2	2	2	1	3	1	3	1	3	5	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:114397643T>C	uc001eds.2	-	8	699	c.569A>G	c.(568-570)TAC>TGC	p.Y190C	uc001edv.1_5'Flank|PTPN22_uc009wgq.2_Missense_Mutation_p.Y190C|PTPN22_uc010owo.1_Intron|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.Y190C|PTPN22_uc009wgs.2_Intron|PTPN22_uc001edu.2_Missense_Mutation_p.Y190C	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	190	Tyrosine-protein phosphatase.				negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAATTCTTGTAATGAAACTG	0.299													30	36					0	0	0	0	C	114397643	C	C	114397643	3	2	145	1	0	0	0	0	1	0	0	0	12852	1638	57	5	1933	5	PTPN22	1	114397643	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	4859393	114397643	134852978	14	26434											
BCL9	607	broad.mit.edu	37	chr1	147095739	147095739	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggaatgacccagccactttCtcactccaatcagatgccct	10	9	7	15	0	2	2	2	1	1	1	4	3	3	3	4	1	2	0	4	1	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:147095739C>G	uc001epq.2	+	10	4000	c.3260C>G	c.(3259-3261)TCT>TGT	p.S1087C	BCL9_uc010ozr.1_Missense_Mutation_p.S1001C	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1087	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CAGCCACTTTCTCACTCCAAT	0.527			T	IGH@|IGL@	B-ALL								4	468					0	0	0	0	G	147095739	G	G	147095739	3	3	145	1	0	0	0	0	1	0	0	0	1383	913	32	2	3286	2	BCL9	1	147095739	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	32698096	147095739	102154882	15	26435											
HIST2H2BF	440689	broad.mit.edu	37	chr1	149783712	149783712	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgcccatggccttggacGagatgccggtgtcggggtgg	5	9	18	9	3	0	2	0	1	0	1	1	4	0	3	3	6	2	0	3	6	0	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:149783712G>T	uc001esr.2	-	1	217	c.167C>A	c.(166-168)TCG>TAG	p.S56*	HIST2H2BF_uc010pbj.1_Nonsense_Mutation_p.S56*|HIST2H2BF_uc010pbk.1_Nonsense_Mutation_p.S56*	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	56					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					GGCCTTGGACGAGATGCCGGT	0.607													134	313					5.71173e-70	1.0819e-69	1	0	T	149783712	T	T	149783712	4	4	145	1	0	0	0	0	0	1	0	0	7219	1059	37	3	634	3	HIST2H2BF	1	149783712	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2687973	149783712	99466909	16	26436											
HIST2H2AB	317772	broad.mit.edu	37	chr1	149859080	149859080	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcaagcctcttaattacttGttcttgccaggcttgtgact	7	16	8	10	0	3	1	1	1	2	0	3	1	3	1	2	1	3	2	2	1	3	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:149859080G>T	uc001ete.2	-	1	387	c.387C>A	c.(385-387)AAC>AAA	p.N129K	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	129					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TTAATTACTTGTTCTTGCCAG	0.498													67	86					7.59065e-32	1.35873e-31	1	0	T	149859080	T	T	149859080	3	4	145	1	0	0	0	0	1	0	0	0	7216	1368	48	4	9	4	HIST2H2AB	1	149859080	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	75368	149859080	99391541	17	26437											
FLG	2312	broad.mit.edu	37	chr1	152275982	152275982	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcatcagaccttccctGggatgtggtgtggctgtgat	6	11	16	8	0	1	2	1	1	0	1	2	4	2	4	2	5	0	2	2	5	0	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:152275982G>A	uc001ezu.1	-	3	11416	c.11380C>T	c.(11380-11382)CAG>TAG	p.Q3794*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3794	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCTTCCCTGGGATGTGGTG	0.572									Ichthyosis				294	562					0	0	0	0	A	152275982	A	A	152275982	4	1	145	1	0	0	0	0	0	1	0	0	5954	1357	47	4	809	4	FLG	1	152275982	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2416902	152275982	96974639	18	26438											
FLG	2312	broad.mit.edu	37	chr1	152283008	152283008	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtctgtccgtgtgtggactCagactgttcatgagagctca	8	12	12	9	1	4	2	3	1	1	2	5	4	5	3	1	1	1	2	1	1	0	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:152283008C>G	uc001ezu.1	-	3	4390	c.4354G>C	c.(4354-4356)GAG>CAG	p.E1452Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1452	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGTGGACTCAGACTGTTCA	0.572									Ichthyosis				10	608					0	0	0	0	G	152283008	G	G	152283008	3	3	145	1	0	0	0	0	1	0	0	0	5954	835	29	2	7835	2	FLG	1	152283008	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	7026	152283008	96967613	19	26439											
JTB	10899	broad.mit.edu	37	chr1	153949693	153949710	+	In_Frame_Del	DEL	CTGGGGGAGGCCAGGCCT	-	-																															aaccagcagaggtggcggccCtgggggaggccaggcctccc																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:153949693_153949710delCTGGGGGAGGCCAGGCCT	uc001fds.2	-	1	742_759	c.19_36delAGGCCTGGCCTCCCCCAG	c.(19-36)AGGCCTGGCCTCCCCCAGdel	p.RPGLPQ7del		NM_006694	NP_006685	O76095	JTB_HUMAN	jumping translocation breakpoint precursor	7_12					apoptosis|cell cycle cytokinesis|mitosis|positive regulation of protein kinase activity	integral to plasma membrane|membrane fraction|microtubule organizing center|midbody|mitochondrion|spindle	protein kinase binding				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGTGGCGGCCCTGGGGGAGGCCAGGCCTCCCGGCACCC	0.638													---	---	---								-	153949710	-	-	153949693	7	5	145	1	0	1	0	1	0	0	0	0	8006	680	24	0	424	0	JTB	1	153949693	In_Frame_Del	DEL	CTGGGGGAGGCCAGGCCT	TCGA-CR-7374-01A-11D-2012-08	1666685	153949693	95300928	20	26440											
C1orf85	112770	broad.mit.edu	37	chr1	156263979	156263979	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaggtgtctgctgtgtgcaGgaggcgagggggttgggctg	5	9	21	6	1	1	0	0	0	1	0	1	2	1	1	0	6	2	4	0	6	0	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:156263979G>C	uc001foh.2	-	4	641	c.628C>G	c.(628-630)CTG>GTG	p.L210V	C1orf85_uc001fof.3_5'Flank|C1orf85_uc001fog.1_Intron|C1orf85_uc001foi.2_Missense_Mutation_p.L210V|C1orf85_uc009wrx.2_Missense_Mutation_p.L143V|C1orf85_uc001foj.2_Missense_Mutation_p.L124V	NM_144580	NP_653181	Q8WWB7	NCUG1_HUMAN	kidney predominant protein NCU-G1 precursor	210	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2	Hepatocellular(266;0.158)					GCTGTGTGCAGGAGGCGAGGG	0.607													15	80					0	0	0	0	C	156263979	C	C	156263979	3	2	145	1	0	0	0	0	1	0	0	0	2072	991	35	4	604	4	C1orf85	1	156263979	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2314286	156263979	92986642	21	26441											
CD5L	922	broad.mit.edu	37	chr1	157803289	157803289	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtctcctcctactagtctCaagtcaaagggatctgcagg	9	12	9	11	0	4	0	2	0	3	0	7	1	5	1	2	2	2	1	2	2	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:157803289C>G	uc001frk.3	-	5	875	c.732G>C	c.(730-732)TTG>TTC	p.L244F		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	244	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTACTAGTCTCAAGTCAAAGG	0.478													4	208					0	0	0	0	G	157803289	G	G	157803289	3	3	145	1	0	0	0	0	1	0	0	0	3042	825	29	2	319	2	CD5L	1	157803289	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1539310	157803289	91447332	22	26442											
OR10X1	128367	broad.mit.edu	37	chr1	158549486	158549486	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataggggtgtggagggacctGtccacccaagttagacccat	10	8	13	10	0	0	1	0	0	0	1	1	3	1	3	4	4	0	1	4	4	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:158549486G>C	uc010pin.1	-	1	204	c.204C>G	c.(202-204)GAC>GAG	p.D68E		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	68	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GGAGGGACCTGTCCACCCAAG	0.478													41	109					0	0	0	0	C	158549486	C	C	158549486	3	2	145	1	0	0	0	0	1	0	0	0	10976	1368	48	4	771	4	OR10X1	1	158549486	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	746197	158549486	90701135	23	26443											
OR6K6	128371	broad.mit.edu	37	chr1	158725260	158725260	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgagcttggcctgcacaGatacattcctagtggtcatt	8	13	10	10	0	1	2	1	1	0	1	2	2	2	2	2	2	4	3	2	2	2	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:158725260G>A	uc001fsw.1	+	1	655	c.655G>A	c.(655-657)GAT>AAT	p.D219N		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	219	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					GGCCTGCACAGATACATTCCT	0.473													36	104					0	0	0	0	A	158725260	A	A	158725260	3	1	145	1	0	0	0	0	1	0	0	0	11258	942	33	2	657	2	OR6K6	1	158725260	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	175774	158725260	90525361	24	26444											
COPA	1314	broad.mit.edu	37	chr1	160264643	160264662	+	Splice_Site	DEL	CTTCCCTACAGAGGGAAGGA	-	-																															tcagcagccagtgctcctccCttccctacagagggaaggaa																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:160264643_160264662delCTTCCCTACAGAGGGAAGGA	uc009wti.2	-	24	2871	c.2477_splice	c.e24-1	p.G826_splice	COPA_uc001fvv.3_Splice_Site_p.G835_splice	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform						COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGCTCCTCCCTTCCCTACAGAGGGAAGGAACAGAACGGA	0.491													---	---	---								-	160264662	-	-	160264643	8	5	145	1	0	1	0	1	0	0	1	0	3742	680	24	0	1233	0	COPA	1	160264643	Splice_Site	DEL	CTTCCCTACAGAGGGAAGGA	TCGA-CR-7374-01A-11D-2012-08	1539383	160264643	88985978	25	26445											
MPZL1	9019	broad.mit.edu	37	chr1	167742587	167742587	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctatagaaggaaaaactCtaaacgggattacactgggt	15	9	9	8	1	2	1	0	0	2	1	2	3	2	3	1	3	3	0	1	3	8	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:167742587C>G	uc001geo.2	+	4	789	c.587C>G	c.(586-588)TCT>TGT	p.S196C	MPZL1_uc001gen.3_Missense_Mutation_p.S196C|MPZL1_uc001gep.2_Missense_Mutation_p.S196C|MPZL1_uc001geq.2_Intron|MPZL1_uc009wvh.2_RNA	NM_003953	NP_003944	O95297	MPZL1_HUMAN	myelin protein zero-like 1 isoform a	196	Cytoplasmic (Potential).				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			ovary(2)	2	all_hematologic(923;0.215)					AGGAAAAACTCTAAACGGGAT	0.438													7	106					0	0	0	0	G	167742587	G	G	167742587	3	3	145	1	0	0	0	0	1	0	0	0	9802	913	32	2	601	2	MPZL1	1	167742587	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	7477944	167742587	81508034	26	26446											
F5	2153	broad.mit.edu	37	chr1	169510654	169510654	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aaatgggcatctgaccgaggGctggggaaaggtttctctga	10	9	15	7	1	2	2	0	2	2	0	3	4	2	3	1	5	0	3	1	5	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:169510654G>T	uc001ggg.1	-	13	3819	c.3674C>A	c.(3673-3675)GCC>GAC	p.A1225D		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1225	2-5.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CTGACCGAGGGCTGGGGAAAG	0.532													204	448					6.2134e-80	1.18005e-79	1	0	T	169510654	T	T	169510654	3	4	145	1	0	0	0	0	1	0	0	0	5373	1203	42	4	3052	4	F5	1	169510654	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1768067	169510654	79739967	27	26447											
FAM5C	339479	broad.mit.edu	37	chr1	190067943	190067943	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctattcgtctgtccgttttCtgcagcagatatttcatctc	6	18	6	11	2	5	1	1	0	4	1	8	1	6	1	1	0	2	3	1	0	2	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:190067943C>T	uc001gse.1	-	8	1738	c.1506G>A	c.(1504-1506)CAG>CAA	p.Q502Q	FAM5C_uc010pot.1_Silent_p.Q400Q	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	502						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TGTCCGTTTTCTGCAGCAGAT	0.498													51	239					0	0	0	0	T	190067943	T	T	190067943	2	4	145	1	0	0	0	0	0	0	0	1	5626	912	32	2		2	FAM5C	1	190067943	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	20557289	190067943	59182678	28	26448											
PIGR	5284	broad.mit.edu	37	chr1	207110641	207110641	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttccccagggtgttgacgaCcacgtcacagttttccccac	7	10	8	16	2	1	1	1	1	0	0	3	2	3	1	5	1	0	2	5	1	0	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:207110641C>A	uc001hez.2	-	4	1028	c.844G>T	c.(844-846)GTC>TTC	p.V282F	PIGR_uc009xbz.2_Missense_Mutation_p.V282F	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	282	Ig-like V-type 3.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GTGTTGACGACCACGTCACAG	0.602													39	96					1.07121e-22	1.84816e-22	1	0	A	207110641	A	A	207110641	3	1	145	1	0	0	0	0	1	0	0	0	11952	507	18	4	1482	4	PIGR	1	207110641	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	17042698	207110641	42139980	29	26449											
TRAF3IP3	80342	broad.mit.edu	37	chr1	209933400	209933400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcatcatgatcagcccagacCccaggccctcccctggcttg	7	8	8	18	0	3	2	3	1	0	1	4	2	4	2	6	2	1	1	6	2	0	1	rs151094826		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:209933400C>T	uc001hho.2	+	3	306	c.16C>T	c.(16-18)CCC>TCC	p.P6S	TRAF3IP3_uc001hhl.2_Missense_Mutation_p.P6S|TRAF3IP3_uc001hhm.1_Missense_Mutation_p.P6S|TRAF3IP3_uc001hhn.2_Missense_Mutation_p.P6S|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.P6S	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	6	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		CAGCCCAGACCCCAGGCCCTC	0.602													18	50					0	0	0	0	T	209933400	T	T	209933400	3	4	145	1	0	0	0	0	1	0	0	0	16509	623	22	4	18	4	TRAF3IP3	1	209933400	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2822759	209933400	39317221	30	26450											
USH2A	7399	broad.mit.edu	37	chr1	215848133	215848133	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgggcggtgaccaacataCattcatttgagtggcactga	10	11	12	8	1	1	3	1	3	0	0	1	3	1	3	1	3	2	1	1	3	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:215848133C>T	uc001hku.1	-	63	13507	c.13120G>A	c.(13120-13122)GTA>ATA	p.V4374I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4374	Extracellular (Potential).|Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GACCAACATACATTCATTTGA	0.488										HNSCC(13;0.011)			27	61					0	0	0	0	T	215848133	T	T	215848133	3	4	145	1	0	0	0	0	1	0	0	0	17104	478	17	4	2528	4	USH2A	1	215848133	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	5914733	215848133	33402488	31	26451											
USH2A	7399	broad.mit.edu	37	chr1	216052268	216052268	+	Frame_Shift_Del	DEL	C	-	-																															accctccaaggtacccattaCcccctgagcaagcaacaatg																								rs148433761		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:216052268delC	uc001hku.1	-	42	8783	c.8396delG	c.(8395-8397)GGTfs	p.G2799fs		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2799	Fibronectin type-III 14.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTACCCATTACCCCCTGAGCA	0.443										HNSCC(13;0.011)			---	---	---								-	216052268	-	-	216052268	7	5	145	1	0	1	0	1	0	0	0	0	17104	507	18	0	7336	0	USH2A	1	216052268	Frame_Shift_Del	DEL	C	TCGA-CR-7374-01A-11D-2012-08	204135	216052268	33198353	32	26452											
ESRRG	2104	broad.mit.edu	37	chr1	216850476	216850476	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catgatgctaccccatagtgGtacccagaagcgatgtcacc	11	8	9	13	1	1	2	1	1	0	1	1	3	1	2	4	1	4	2	4	1	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:216850476G>C	uc001hkw.1	-	2	580	c.414C>G	c.(412-414)TAC>TAG	p.Y138*	ESRRG_uc001hky.1_Nonsense_Mutation_p.Y115*|ESRRG_uc009xdp.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hkz.1_Nonsense_Mutation_p.Y115*|ESRRG_uc010puc.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hla.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hlb.1_Nonsense_Mutation_p.Y115*|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hld.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hkx.1_Nonsense_Mutation_p.Y143*|ESRRG_uc009xdo.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hle.1_Nonsense_Mutation_p.Y115*	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	138	Nuclear receptor.|NR C4-type.				positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CCCCATAGTGGTACCCAGAAG	0.498													56	138					0	0	0	0	C	216850476	C	C	216850476	4	2	145	1	0	0	0	0	0	1	0	0	5286	1256	44	4	986	4	ESRRG	1	216850476	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	798208	216850476	32400145	33	26453											
LBR	3930	broad.mit.edu	37	chr1	225598118	225598118	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catcaccaagttaataaccaCctgaaacaaaaggggaaagt	19	6	7	9	0	1	1	1	1	0	0	1	2	1	2	3	2	2	1	3	2	7	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:225598118C>A	uc001hoy.2	-	10	1332	c.1189G>T	c.(1189-1191)GTG>TTG	p.V397L	LBR_uc001hoz.2_Missense_Mutation_p.V397L|LBR_uc001hpa.1_Missense_Mutation_p.V397L	NM_002296	NP_002287	Q14739	LBR_HUMAN	lamin B receptor	397	Helical; (Potential).				cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			ovary(1)|skin(1)	2	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		TTAATAACCACCTGAAACAAA	0.244													41	83					1.47197e-15	2.37907e-15	1	0	A	225598118	A	A	225598118	3	1	145	1	0	0	0	0	1	0	0	0	8692	521	18	4	678	4	LBR	1	225598118	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	8747642	225598118	23652503	34	26454											
C1orf55	163859	broad.mit.edu	37	chr1	226176001	226176001	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttggagcatggaaacccaTtcctgaagtgcttggtgctt	8	14	11	8	0	0	1	0	1	0	0	1	3	1	3	2	3	4	3	2	3	2	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:226176001T>C	uc001hpu.3	-	6	783	c.730A>G	c.(730-732)ATG>GTG	p.M244V	C1orf55_uc001hpv.2_Missense_Mutation_p.M244V	NM_152608	NP_689821	Q6IQ49	CA055_HUMAN	hypothetical protein LOC163859	244										lung(1)	1	Breast(184;0.197)					TGGAAACCCATTCCTGAAGTG	0.498													92	204					0	0	0	0	C	226176001	C	C	226176001	3	2	145	1	0	0	0	0	1	0	0	0	2057	1493	52	5	633	5	C1orf55	1	226176001	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	577883	226176001	23074620	35	26455											
TTC13	79573	broad.mit.edu	37	chr1	231069578	231069578	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataaagtcaactttctgcttCaaagcttctttgaaggattc	12	15	6	8	0	4	1	2	1	2	0	5	2	4	2	0	1	3	2	0	1	5	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:231069578C>G	uc001huf.3	-	9	961	c.930G>C	c.(928-930)TTG>TTC	p.L310F	TTC13_uc009xfi.2_Missense_Mutation_p.L257F|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.L257F|TTC13_uc009xfk.1_Missense_Mutation_p.L200F	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	310	TPR 4.						binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CTTTCTGCTTCAAAGCTTCTT	0.328													21	88					0	0	0	0	G	231069578	G	G	231069578	3	3	145	1	0	0	0	0	1	0	0	0	16748	825	29	2	1712	2	TTC13	1	231069578	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	4893577	231069578	18181043	36	26456											
HEATR1	55127	broad.mit.edu	37	chr1	236724551	236724551	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaggccttttaaaatctcAggaccaccactctcaactac	13	10	4	14	0	3	0	3	0	2	0	5	1	3	1	3	2	2	0	3	2	5	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:236724551A>G	uc001hyd.1	-	33	4745	c.4620T>C	c.(4618-4620)CCT>CCC	p.P1540P	HEATR1_uc009xgh.1_Silent_p.P702P	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1540					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTAAAATCTCAGGACCACCAC	0.269													3	148					0	0	0	0	G	236724551	G	G	236724551	2	3	145	1	0	0	0	0	0	0	0	1	7066	175	7	5		5	HEATR1	1	236724551	Silent	SNP	A	TCGA-CR-7374-01A-11D-2012-08	5654973	236724551	12526070	37	26457											
RYR2	6262	broad.mit.edu	37	chr1	237951342	237951342	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagacaagggcaaacaaaaGttgaggcagcttcacacaca	18	4	10	9	0	1	2	1	1	0	1	1	3	1	2	0	2	2	4	0	2	5	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:237951342G>T	uc001hyl.1	+	92	13503	c.13383G>T	c.(13381-13383)AAG>AAT	p.K4461N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4461					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCAAACAAAAGTTGAGGCAGC	0.398													13	18					9.31168e-06	1.3948e-05	1	0	T	237951342	T	T	237951342	3	4	145	1	0	0	0	0	1	0	0	0	13834	1020	36	4	13749	4	RYR2	1	237951342	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1226791	237951342	11299279	38	26458											
FMN2	56776	broad.mit.edu	37	chr1	240256603	240256603	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgcggccgcttccctgccCggcagccccgcgcctagcca	3	4	11	23	6	0	0	0	0	0	0	1	0	1	0	8	2	3	2	8	2	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:240256603C>A	uc010pyd.1	+	1	1419	c.1194C>A	c.(1192-1194)CCC>CCA	p.P398P	FMN2_uc010pye.1_Silent_p.P398P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	398					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTTCCCTGCCCGGCAGCCCCG	0.706													36	76					3.03874e-20	5.11938e-20	1	0	A	240256603	A	A	240256603	2	1	145	1	0	0	0	0	0	0	0	1	5982	639	23	3		3	FMN2	1	240256603	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2305261	240256603	8994018	39	26459											
FMN2	56776	broad.mit.edu	37	chr1	240371048	240371048	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agcaggaatacctcctccacCccctctacccggagcgggca	9	5	9	18	2	1	0	0	0	1	0	3	2	3	2	6	3	4	2	6	3	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:240371048C>A	uc010pyd.1	+	5	3161	c.2936C>A	c.(2935-2937)CCC>CAC	p.P979H	FMN2_uc010pye.1_Missense_Mutation_p.P983H	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	979	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTCCTCCACCCCCTCTACCC	0.716													36	52					2.6416e-12	4.20308e-12	1	0	A	240371048	A	A	240371048	3	1	145	1	0	0	0	0	1	0	0	0	5982	623	22	4	2954	4	FMN2	1	240371048	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	114445	240371048	8879573	40	26460											
FMN2	56776	broad.mit.edu	37	chr1	240635698	240635698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaagccgaagaggtgtgtaGacagaagaaaggaaaatcac	19	4	13	5	1	1	5	1	0	0	5	1	7	1	6	1	2	1	1	1	2	7	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:240635698G>A	uc010pyd.1	+	17	5312	c.5087G>A	c.(5086-5088)AGA>AAA	p.R1696K	FMN2_uc010pye.1_Missense_Mutation_p.R1700K|FMN2_uc010pyg.1_Missense_Mutation_p.R292K|FMN2_uc001hyr.2_RNA	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1696	Potential.|FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GAGGTGTGTAGACAGAAGAAA	0.328													23	76					0	0	0	0	A	240635698	A	A	240635698	3	1	145	1	0	0	0	0	1	0	0	0	5982	942	33	2	5153	2	FMN2	1	240635698	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	264650	240635698	8614923	41	26461											
RGS7	6000	broad.mit.edu	37	chr1	241519074	241519074	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccataattattcccctgggcCatgtcacccaaaacttggtc	10	11	6	14	0	1	0	1	0	0	0	3	0	2	0	5	2	1	0	5	2	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:241519074C>A	uc001hyv.2	-	2	333	c.3G>T	c.(1-3)ATG>ATT	p.M1I	RGS7_uc001hyu.2_Missense_Mutation_p.M1I|RGS7_uc009xgn.1_Missense_Mutation_p.M1I|RGS7_uc001hyw.2_Missense_Mutation_p.M1I	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	1					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCCCCTGGGCCATGTCACCCA	0.498													42	91					4.67007e-22	8.01863e-22	1	0	A	241519074	A	A	241519074	3	1	145	1	0	0	0	0	1	0	0	0	13375	594	21	4	1528	4	RGS7	1	241519074	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	883376	241519074	7731547	42	26462											
OR2W5	441932	broad.mit.edu	37	chr1	247655015	247655015	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaggaaaccatgctggtaGaagcgattcacctttgccct	10	10	11	10	1	1	2	1	1	0	1	1	4	1	3	3	2	4	2	3	2	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:247655015G>T	uc001icz.1	+	1	586	c.586G>T	c.(586-588)GAA>TAA	p.E196*		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CATGCTGGTAGAAGCGATTCA	0.587													81	146					4.41824e-40	8.17431e-40	1	0	T	247655015	T	T	247655015	4	4	145	1	0	0	0	0	0	1	0	0	11088	943	33	2	588	2	OR2W5	1	247655015	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	6135941	247655015	1595606	43	26463											
OR2C3	81472	broad.mit.edu	37	chr1	247695641	247695641	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagaaagaagtacataggtGtgtggaggtgcacatctgta	14	9	13	5	0	1	2	0	0	1	2	1	3	1	3	0	3	2	3	0	3	6	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:247695641G>T	uc009xgy.2	-	2	535	c.173C>A	c.(172-174)ACA>AAA	p.T58K	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	58	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			GTACATAGGTGTGTGGAGGTG	0.488													53	92					1.11015e-26	1.95299e-26	1	0	T	247695641	T	T	247695641	3	4	145	1	0	0	0	0	1	0	0	0	11047	1377	48	4	793	4	OR2C3	1	247695641	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	40626	247695641	1554980	44	26464											
TRIM58	25893	broad.mit.edu	37	chr1	248039588	248039588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttcttggactatgaagccGgtgaaatttcattctacaat	11	16	7	7	1	3	2	1	2	2	0	3	3	3	3	1	2	2	0	1	2	5	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:248039588G>A	uc001ido.2	+	6	1306	c.1258G>A	c.(1258-1260)GGT>AGT	p.G420S	OR2W3_uc001idp.1_Intron	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	420	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTATGAAGCCGGTGAAATTTC	0.448													124	220					0	0	0	0	A	248039588	A	A	248039588	3	1	145	1	0	0	0	0	1	0	0	0	16598	1116	39	1	1280	1	TRIM58	1	248039588	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	343947	248039588	1211033	45	26465											
OR2AK2	391191	broad.mit.edu	37	chr1	248129228	248129228	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttctgtgaagttccagctCtactatcattggtgtgtcag	7	17	9	8	0	4	1	2	1	2	0	5	1	5	1	1	1	2	2	1	1	3	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:248129228C>A	uc010pzd.1	+	1	595	c.595C>A	c.(595-597)CTA>ATA	p.L199I	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			AGTTCCAGCTCTACTATCATT	0.428													12	114					3.07112e-06	4.62931e-06	1	0	A	248129228	A	A	248129228	3	1	145	1	0	0	0	0	1	0	0	0	11040	912	32	2	597	2	OR2AK2	1	248129228	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	89640	248129228	1121393	46	26466											
OR2T4	127074	broad.mit.edu	37	chr1	248525904	248525904	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatgttaacagtggaacCtgcctttcaaaaagctatgg	15	10	9	7	0	1	0	1	0	0	0	1	2	1	1	2	2	4	2	2	2	7	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:248525904C>T	uc001ieh.1	+	1	1022	c.1022C>T	c.(1021-1023)CCT>CTT	p.P341L		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	341	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGTGGAACCTGCCTTTCAA	0.393													5	238					0	0	0	0	T	248525904	T	T	248525904	3	4	145	1	0	0	0	0	1	0	0	0	11081	681	24	4	1024	4	OR2T4	1	248525904	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	396676	248525904	724717	47	26467											
OR2T27	403239	broad.mit.edu	37	chr1	248813773	248813773	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caatcaaccagcagatcttgCggctcatgaggacaggatag	13	7	11	10	1	3	2	2	1	1	1	3	4	3	4	1	3	3	2	1	3	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:248813773C>G	uc010pzo.1	-	1	413	c.413G>C	c.(412-414)CGC>CCC	p.R138P		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCAGATCTTGCGGCTCATGAG	0.557													50	128					0	0	0	0	G	248813773	G	G	248813773	3	3	145	1	0	0	0	0	1	0	0	0	11075	768	27	3	543	3	OR2T27	1	248813773	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	287869	248813773	436848	48	26468											
NTSR2	23620	broad.mit.edu	37	chr2	11809734	11809734	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgagttcgtgcttctgcccCatgatgacggccatgggcag	6	10	13	12	3	1	2	0	2	1	0	3	3	1	2	3	2	2	3	3	2	0	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:11809734C>A	uc002rbq.3	-	1	596	c.522G>T	c.(520-522)ATG>ATT	p.M174I		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	174	Helical; Name=4; (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	GCTTCTGCCCCATGATGACGG	0.721													19	14					2.94398e-08	4.51369e-08	1	0	A	11809734	A	A	11809734	3	1	145	1	0	0	0	0	1	0	0	0	10765	594	21	4	726	4	NTSR2	2	11809734	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08		11809734	231389639	49	26469											
ITSN2	50618	broad.mit.edu	37	chr2	24507701	24507701	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgaagaacagagtcatcCatattcccacactgtaagat	15	9	6	11	0	1	4	1	1	0	3	3	4	3	4	2	0	1	1	2	0	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:24507701C>G	uc002rfe.2	-	17	2133	c.1875G>C	c.(1873-1875)ATG>ATC	p.M625I	ITSN2_uc002rff.2_Intron|ITSN2_uc002rfg.2_Missense_Mutation_p.M625I	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	625	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGAGTCATCCATATTCCCAC	0.284													34	50					0	0	0	0	G	24507701	G	G	24507701	3	3	145	1	0	0	0	0	1	0	0	0	7966	594	21	4	3365	4	ITSN2	2	24507701	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	12697967	24507701	218691672	50	26470											
UGP2	7360	broad.mit.edu	37	chr2	64085024	64085024	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tagatttttgcaagaaaaggGgccttctgtggattggggaa	11	12	14	4	0	1	2	0	0	1	2	1	4	1	4	1	5	1	1	1	5	5	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:64085024G>T	uc002scm.2	+	3	515	c.209G>T	c.(208-210)GGG>GTG	p.G70V	UGP2_uc002scl.2_Missense_Mutation_p.G59V|UGP2_uc010ypx.1_Missense_Mutation_p.G79V	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	70					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						CAAGAAAAGGGGCCTTCTGTG	0.403													118	271					3.21087e-66	6.06592e-66	1	0	T	64085024	T	T	64085024	3	4	145	1	0	0	0	0	1	0	0	0	17011	1232	43	4	219	4	UGP2	2	64085024	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	39577323	64085024	179114349	51	26471											
ANKRD53	79998	broad.mit.edu	37	chr2	71206951	71206951	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caccaccgtggccctcccctGcatctactacctgctggaga	7	8	8	18	1	1	1	0	0	1	1	2	2	2	1	6	2	4	2	6	2	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:71206951G>T	uc002shl.3	+	3	779	c.578G>T	c.(577-579)TGC>TTC	p.C193F	ANKRD53_uc002shk.3_Missense_Mutation_p.C193F|ANKRD53_uc002shm.3_Missense_Mutation_p.C159F	NM_001115116	NP_001108588	Q8N9V6	ANR53_HUMAN	ankyrin repeat domain 53 isoform a	193	ANK 2.										0						GCCCTCCCCTGCATCTACTAC	0.602													36	76					4.3949e-29	7.78898e-29	1	0	T	71206951	T	T	71206951	3	4	145	1	0	0	0	0	1	0	0	0	679	1319	46	4	588	4	ANKRD53	2	71206951	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	7121927	71206951	171992422	52	26472											
REG1A	5967	broad.mit.edu	37	chr2	79349251	79349251	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcctccatgaccccaaaaaGgtaggctgcagccttcttta	10	9	9	13	0	1	1	0	1	1	0	2	1	2	1	5	3	2	3	5	3	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:79349251G>T	uc002snz.2	+	4	424	c.321G>T	c.(319-321)AAG>AAT	p.K107N	REG1A_uc010ffx.1_3'UTR|REG1A_uc010ysd.1_Missense_Mutation_p.K107N	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	107	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						ACCCCAAAAAGGTAGGCTGCA	0.488													41	80					1.96642e-18	3.23668e-18	1	0	T	79349251	T	T	79349251	3	4	145	1	0	0	0	0	1	0	0	0	13275	1014	35	4	331	4	REG1A	2	79349251	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	8142300	79349251	163850122	53	26473											
REG3A	5068	broad.mit.edu	37	chr2	79386513	79386513	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catccaagatacactgggcaGggccatgggaggcagcatag	12	5	14	10	0	0	1	0	0	0	1	1	2	1	2	2	4	2	3	2	4	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:79386513G>T	uc002sod.1	-	1	274	c.19C>A	c.(19-21)CTG>ATG	p.L7M	REG3A_uc002soe.1_Missense_Mutation_p.L7M|REG3A_uc002sof.1_Missense_Mutation_p.L7M	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	7					acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						ACACTGGGCAGGGCCATGGGA	0.532													24	83					1.38267e-23	2.40289e-23	1	0	T	79386513	T	T	79386513	3	4	145	1	0	0	0	0	1	0	0	0	13277	991	35	4	528	4	REG3A	2	79386513	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	37262	79386513	163812860	54	26474											
CTNNA2	1496	broad.mit.edu	37	chr2	80874994	80874994	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaagcaatggattccttCtaggacgataggttttaaca	13	13	8	7	1	2	0	1	0	1	0	3	3	3	2	1	3	2	2	1	3	5	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:80874994C>A	uc010ysh.1	+	18	2864	c.2859C>A	c.(2857-2859)TTC>TTA	p.F953L	CTNNA2_uc010yse.1_Missense_Mutation_p.F905L|CTNNA2_uc010ysf.1_Missense_Mutation_p.F905L|CTNNA2_uc010ysg.1_Missense_Mutation_p.F860L|CTNNA2_uc010ysi.1_Missense_Mutation_p.F537L|CTNNA2_uc010ysj.1_Missense_Mutation_p.F234L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	953					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TGGATTCCTTCTAGGACGATA	0.343													74	147					9.88329e-16	1.601e-15	1	0	A	80874994	A	A	80874994	3	1	145	1	0	0	0	0	1	0	0	0	4030	912	32	2	2573	2	CTNNA2	2	80874994	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1488481	80874994	162324379	55	26475											
FABP1	2168	broad.mit.edu	37	chr2	88424028	88424028	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacattggtgattatgtcGccgttgagttcggtcacaga	8	14	11	8	3	1	3	1	2	0	1	3	3	1	3	1	2	1	2	1	2	2	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:88424028G>A	uc002sst.1	-	3	360	c.318C>T	c.(316-318)GGC>GGT	p.G106G	FABP1_uc002ssu.2_Silent_p.G106G	NM_001443	NP_001434	P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	106					organ morphogenesis						0						TGATTATGTCGCCGTTGAGTT	0.522													40	75					0	0	0	0	A	88424028	A	A	88424028	2	1	145	1	0	0	0	0	0	0	0	1	5383	1074	38	1		1	FABP1	2	88424028	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	7549034	88424028	154775345	56	26476											
MITD1	129531	broad.mit.edu	37	chr2	99787024	99787024	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttctcggtcatgtattgaaGaagagtattgaacttccaac	12	14	8	7	1	2	4	1	2	1	2	4	4	3	4	1	1	2	2	1	1	6	6	rs144672860		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:99787024G>A	uc002szs.1	-	5	617	c.569C>T	c.(568-570)TCT>TTT	p.S190F	MRPL30_uc002szl.1_Intron|MRPL30_uc002szr.2_Intron	NM_138798	NP_620153	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport,	190					protein transport	late endosome membrane				large_intestine(1)|ovary(1)	2						ATGTATTGAAGAAGAGTATTG	0.313													105	264					0	0	0	0	A	99787024	A	A	99787024	3	1	145	1	0	0	0	0	1	0	0	0	9648	942	33	2	192	2	MITD1	2	99787024	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	11362996	99787024	143412349	57	26477											
DPP10	57628	broad.mit.edu	37	chr2	116257182	116257182	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attggaaaacacaacttttgTaagtaatgaataattaatta	19	14	5	3	0	0	1	0	1	0	0	0	2	0	2	0	1	2	2	0	1	9	8			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:116257182T>A	uc002tla.1	+	4	823	c.366_splice	c.e4+2	p.F122_splice	DPP10_uc002tlb.1_Splice_Site_p.F72_splice|DPP10_uc002tlc.1_Splice_Site_p.F118_splice|DPP10_uc002tle.2_Splice_Site_p.F126_splice|DPP10_uc002tlf.1_Splice_Site_p.F115_splice	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long						proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ACAACTTTTGTAAGTAATGAA	0.313													21	37					0	0	0	0	A	116257182	A	A	116257182	5	1	145	1	0	0	0	0	0	0	1	0	4749	1652	57	5	553	5	DPP10	2	116257182	Splice_Site	SNP	T	TCGA-CR-7374-01A-11D-2012-08	16470158	116257182	126942191	58	26478											
IMP4	92856	broad.mit.edu	37	chr2	131100699	131100699	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgccgcgagtacctgtaccGcaaggcccgggaggaggcgc	7	3	17	14	6	0	0	0	0	0	0	0	3	0	2	4	4	2	3	4	4	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:131100699G>T	uc002tra.1	+	2	61	c.44G>T	c.(43-45)CGC>CTC	p.R15L	CCDC115_uc002tqw.1_5'Flank|CCDC115_uc010zaf.1_5'Flank|CCDC115_uc002tqx.2_5'Flank|CCDC115_uc002tqy.1_5'Flank|CCDC115_uc002tqz.1_5'Flank	NM_033416	NP_219484	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein,	15	Arg-rich.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)	2	Colorectal(110;0.1)					TACCTGTACCGCAAGGCCCGG	0.736													6	12					0.000157383	0.000232823	1	0	T	131100699	T	T	131100699	3	4	145	1	0	0	0	0	1	0	0	0	7759	1087	38	3	50	3	IMP4	2	131100699	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	14843517	131100699	112098674	59	26479											
FAM123C	205147	broad.mit.edu	37	chr2	131521734	131521734	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agcccccggccgcatggcctCcaaggcaagacatgggcagt	9	4	13	15	2	0	1	0	0	0	1	1	1	1	1	5	4	1	3	5	4	2	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:131521734C>T	uc002trw.2	+	2	2279	c.2089C>T	c.(2089-2091)CCA>TCA	p.P697S	FAM123C_uc010fmv.2_Missense_Mutation_p.P697S|FAM123C_uc010fms.1_Missense_Mutation_p.P697S|FAM123C_uc010fmt.1_Missense_Mutation_p.P697S|FAM123C_uc010fmu.1_Missense_Mutation_p.P697S	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	697										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CGCATGGCCTCCAAGGCAAGA	0.642													18	32					0	0	0	0	T	131521734	T	T	131521734	3	4	145	1	0	0	0	0	1	0	0	0	5452	855	30	2	2091	2	FAM123C	2	131521734	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	421035	131521734	111677639	60	26480											
LRP1B	53353	broad.mit.edu	37	chr2	141032165	141032165	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacaatagtggtggcacaCgtctaggaaaaaaaggcaca	17	5	10	9	1	1	0	0	0	1	0	1	1	1	1	0	4	0	2	0	4	6	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:141032165C>A	uc002tvj.1	-	85	13942	c.12970G>T	c.(12970-12972)GTG>TTG	p.V4324L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4324	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGGTGGCACACGTCTAGGAAA	0.353										TSP Lung(27;0.18)			21	36					0.000132079	0.0001962	1	0	A	141032165	A	A	141032165	3	1	145	1	0	0	0	0	1	0	0	0	9005	536	19	3	857	3	LRP1B	2	141032165	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	9510431	141032165	102167208	61	26481											
ARHGAP15	55843	broad.mit.edu	37	chr2	143986215	143986215	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaattttacaaagaatccaAgcaacaggctctgtccaata	16	10	6	9	0	1	2	0	1	1	1	3	2	3	2	2	1	3	2	2	1	8	3	rs150643555		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:143986215A>G	uc002tvm.3	+	5	513	c.362A>G	c.(361-363)AAG>AGG	p.K121R	ARHGAP15_uc010zbl.1_Missense_Mutation_p.K121R	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	121	PH.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		AAAGAATCCAAGCAACAGGCT	0.299													37	62					0	0	0	0	G	143986215	G	G	143986215	3	3	145	1	0	0	0	0	1	0	0	0	866	72	3	5	376	5	ARHGAP15	2	143986215	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	2954050	143986215	99213158	62	26482											
PRPF40A	55660	broad.mit.edu	37	chr2	153573823	153573823	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agccggacaatctccgctccCcgtccccaggaccctgcgag	7	5	10	19	4	1	0	0	0	1	0	4	3	3	2	7	2	2	1	7	2	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:153573823C>T	uc002tyi.2	-	1	99	c.86G>A	c.(85-87)GGG>GAG	p.G29E	ARL6IP6_uc002tyn.2_5'Flank|ARL6IP6_uc002tym.2_5'Flank|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_Intron|PRPF40A_uc010zcd.1_Intron|PRPF40A_uc002tyj.2_Intron|PRPF40A_uc002tyl.1_Missense_Mutation_p.G29E	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	29					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						TCTCCGCTCCCCGTCCCCAGG	0.657													10	32					0	0	0	0	T	153573823	T	T	153573823	3	4	145	1	0	0	0	0	1	0	0	0	12633	638	22	4		4	PRPF40A	2	153573823	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	9587608	153573823	89625550	63	26483											
SCN1A	6323	broad.mit.edu	37	chr2	166847776	166847776	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatttccctttggctttttcAtctttgccttcttgctcatg	3	22	5	11	0	4	0	2	0	2	0	5	0	5	0	2	1	2	2	2	1	1	8			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:166847776A>T	uc010zcz.1	-	26	5994	c.5976T>A	c.(5974-5976)GAT>GAA	p.D1992E		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	2003						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGGCTTTTTCATCTTTGCCTT	0.378													28	43					0	0	0	0	T	166847776	T	T	166847776	3	4	145	1	0	0	0	0	1	0	0	0	13979	214	8	5	24	5	SCN1A	2	166847776	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	13273953	166847776	76351597	64	26484											
SCN9A	6335	broad.mit.edu	37	chr2	167056097	167056097	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcaaatcatactgttgccAaaggtctcaaaattgaacat	16	10	7	8	0	2	1	2	1	1	0	3	1	2	1	1	2	3	2	1	2	6	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:167056097A>G	uc010fpl.2	-	27	5360	c.5019T>C	c.(5017-5019)TTT>TTC	p.F1673F	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1684	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TACTGTTGCCAAAGGTCTCAA	0.423													97	277					0	0	0	0	G	167056097	G	G	167056097	2	3	145	1	0	0	0	0	0	0	0	1	13990	127	5	5		5	SCN9A	2	167056097	Silent	SNP	A	TCGA-CR-7374-01A-11D-2012-08	208321	167056097	76143276	65	26485											
XIRP2	129446	broad.mit.edu	37	chr2	168103763	168103763	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgctaaagctgtgatggCaggatcctcgggagagcaga	12	7	15	7	1	0	4	0	1	0	3	2	6	1	5	1	3	3	4	1	3	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:168103763C>A	uc002udx.2	+	8	5879	c.5861C>A	c.(5860-5862)GCA>GAA	p.A1954E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.A1779E|XIRP2_uc010fpq.2_Missense_Mutation_p.A1732E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1779					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GCTGTGATGGCAGGATCCTCG	0.423													19	66					0.000132079	0.0001962	1	0	A	168103763	A	A	168103763	3	1	145	1	0	0	0	0	1	0	0	0	17498	710	25	4	5891	4	XIRP2	2	168103763	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1047666	168103763	75095610	66	26486											
XIRP2	129446	broad.mit.edu	37	chr2	168107805	168107805	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatccgcaaggttgcagtGcctcctcgcctgtcagagca	8	9	10	14	2	2	1	2	0	0	1	5	1	4	1	4	1	3	4	4	1	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:168107805G>A	uc002udx.2	+	8	9921	c.9903G>A	c.(9901-9903)GTG>GTA	p.V3301V	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.V3126V|XIRP2_uc010fpq.2_Silent_p.V3079V|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3126					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGGTTGCAGTGCCTCCTCGCC	0.438													54	144					0	0	0	0	A	168107805	A	A	168107805	2	1	145	1	0	0	0	0	0	0	0	1	17498	1306	46	4		4	XIRP2	2	168107805	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4042	168107805	75091568	67	26487											
MYO3B	140469	broad.mit.edu	37	chr2	171260886	171260886	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaggaaagtcggtttcccCaagcaactgaccagaccctg	12	7	10	12	1	0	3	0	2	0	1	2	4	1	4	4	2	2	2	4	2	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:171260886C>A	uc002ufy.2	+	20	2550	c.2407C>A	c.(2407-2409)CAA>AAA	p.Q803K	MYO3B_uc002ufv.2_Missense_Mutation_p.Q790K|MYO3B_uc010fqb.1_Missense_Mutation_p.Q790K|MYO3B_uc002ufz.2_Missense_Mutation_p.Q803K|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	803	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						TCGGTTTCCCCAAGCAACTGA	0.468													36	72					1.36161e-19	2.27784e-19	1	0	A	171260886	A	A	171260886	3	1	145	1	0	0	0	0	1	0	0	0	10130	595	21	4	2485	4	MYO3B	2	171260886	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	3153081	171260886	71938487	68	26488											
TTN	7273	broad.mit.edu	37	chr2	179452324	179452324	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atattttcctgagtcatcacGggtagaattggggatgacaa	12	12	11	6	1	2	3	2	2	0	1	3	4	3	4	1	3	0	1	1	3	4	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:179452324G>A	uc010zfg.1	-	255	56232	c.56008C>T	c.(56008-56010)CGT>TGT	p.R18670C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R12365C|TTN_uc010zfi.1_Missense_Mutation_p.R12298C|TTN_uc010zfj.1_Missense_Mutation_p.R12173C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19597							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGTCATCACGGGTAGAATTG	0.413													17	63					0	0	0	0	A	179452324	A	A	179452324	3	1	145	1	0	0	0	0	1	0	0	0	16803	1116	39	1	44495	1	TTN	2	179452324	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	8191438	179452324	63747049	69	26489											
TTN	7273	broad.mit.edu	37	chr2	179469614	179469614	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aacagcaagatttcttggtgGggatgggcggtctggaaagg	10	9	17	5	1	2	1	0	0	2	1	2	3	2	3	0	7	2	1	0	7	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:179469614G>C	uc010zfg.1	-	230	46722	c.46498C>G	c.(46498-46500)CCA>GCA	p.P15500A	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P9195A|TTN_uc010zfi.1_Missense_Mutation_p.P9128A|TTN_uc010zfj.1_Missense_Mutation_p.P9003A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16427							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTTGGTGGGGATGGGCGG	0.423													56	133					0	0	0	0	C	179469614	C	C	179469614	3	2	145	1	0	0	0	0	1	0	0	0	16803	1232	43	4	53819	4	TTN	2	179469614	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	17290	179469614	63729759	70	26490											
ZNF385B	151126	broad.mit.edu	37	chr2	180308165	180308165	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggctggggccaaaggctTcatcatatctttctggaatg	10	11	12	8	0	4	0	2	0	2	0	4	2	4	1	1	5	0	2	1	5	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:180308165T>C	uc002unn.3	-	10	1832	c.1228A>G	c.(1228-1230)AAG>GAG	p.K410E	ZNF385B_uc002unj.2_Missense_Mutation_p.K308E|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Missense_Mutation_p.K307E|ZNF385B_uc002unm.2_Missense_Mutation_p.K334E	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	410						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GCCAAAGGCTTCATCATATCT	0.562													8	28					0	0	0	0	C	180308165	C	C	180308165	3	2	145	1	0	0	0	0	1	0	0	0	17944	1792	62	5	191	5	ZNF385B	2	180308165	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	838551	180308165	62891208	71	26491											
ZNF385B	151126	broad.mit.edu	37	chr2	180383318	180383318	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtttcttctttgggggaatGgatactccaaatgtatggtt	8	17	11	5	0	2	0	0	0	2	0	3	2	3	2	1	4	1	3	1	4	4	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:180383318G>T	uc002unn.3	-	5	1048	c.444C>A	c.(442-444)TCC>TCA	p.S148S	ZNF385B_uc002unj.2_Silent_p.S46S|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Silent_p.S45S|ZNF385B_uc002unm.2_Silent_p.S72S	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	148						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TTGGGGGAATGGATACTCCAA	0.343													72	126					4.38973e-58	8.24946e-58	1	0	T	180383318	T	T	180383318	2	4	145	1	0	0	0	0	0	0	0	1	17944	1335	47	4		4	ZNF385B	2	180383318	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	75153	180383318	62816055	72	26492											
ZNF804A	91752	broad.mit.edu	37	chr2	185801142	185801142	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaaataccactagagagtgTtgttattaatgaagacatac	16	12	7	6	0	1	3	1	1	0	2	1	4	1	3	1	0	2	2	1	0	7	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:185801142T>C	uc002uph.2	+	4	1613	c.1019T>C	c.(1018-1020)GTT>GCT	p.V340A		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	340						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CTAGAGAGTGTTGTTATTAAT	0.333													36	80					0	0	0	0	C	185801142	C	C	185801142	3	2	145	1	0	0	0	0	1	0	0	0	18237	1725	60	5	1033	5	ZNF804A	2	185801142	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	5417824	185801142	57398231	73	26493											
NAB1	4664	broad.mit.edu	37	chr2	191555023	191555023	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagcttttaccttagaaaaGaaagtcatcaaaacagagcc	17	9	6	9	0	3	3	3	0	0	3	3	3	3	3	2	0	4	1	2	0	7	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:191555023G>C	uc002usb.2	+	10	2000	c.1428G>C	c.(1426-1428)AAG>AAC	p.K476N	NAB1_uc010fsc.2_Missense_Mutation_p.K476N|NAB1_uc010fsd.2_Missense_Mutation_p.K475N|NAB1_uc002usc.2_Missense_Mutation_p.K475N|NAB1_uc010zgh.1_Missense_Mutation_p.K446N	NM_005966	NP_005957	Q13506	NAB1_HUMAN	NGFI-A binding protein 1	476					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			CCTTAGAAAAGAAAGTCATCA	0.353													4	428					0	0	0	0	C	191555023	C	C	191555023	3	2	145	1	0	0	0	0	1	0	0	0	10184	933	33	2	1454	2	NAB1	2	191555023	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	5753881	191555023	51644350	74	26494											
ANKRD44	91526	broad.mit.edu	37	chr2	197863757	197863757	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctccacatgatcagcaaatgCtgccgcatgaaggggtgtcc	10	8	11	12	1	1	2	1	2	0	0	3	2	3	2	3	2	3	3	3	2	2	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:197863757C>A	uc002uua.1	-	24	2541	c.2464G>T	c.(2464-2466)GCA>TCA	p.A822S	ANKRD44_uc002utz.3_Missense_Mutation_p.A554S	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	847	ANK 25.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCAGCAAATGCTGCCGCATGA	0.438													18	87					5.35267e-07	8.13696e-07	1	0	A	197863757	A	A	197863757	3	1	145	1	0	0	0	0	1	0	0	0	672	797	28	4	307	4	ANKRD44	2	197863757	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	6308734	197863757	45335616	75	26495											
ALS2	57679	broad.mit.edu	37	chr2	202575803	202575803	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccaaactctctagtgtctGagtctgtgaacgactcagta	10	13	8	10	1	4	2	1	2	3	0	6	3	5	2	1	0	2	1	1	0	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:202575803G>C	uc002uyo.2	-	26	4389	c.4033C>G	c.(4033-4035)CAG>GAG	p.Q1345E	ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	1345					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TCTAGTGTCTGAGTCTGTGAA	0.363													27	102					0	0	0	0	C	202575803	C	C	202575803	3	2	145	1	0	0	0	0	1	0	0	0	550	1299	45	2	976	2	ALS2	2	202575803	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4712046	202575803	40623570	76	26496											
PIKFYVE	200576	broad.mit.edu	37	chr2	209180091	209180091	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccgtcagtttgtccacatCaaaaaagtgagctctgctaa	13	11	7	10	1	3	1	2	1	1	0	5	1	5	1	2	0	2	3	2	0	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:209180091C>T	uc002vcz.2	+	15	2159	c.2001C>T	c.(1999-2001)ATC>ATT	p.I667I	PIKFYVE_uc010fun.1_Silent_p.I348I|PIKFYVE_uc002vcy.1_Silent_p.I611I	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	667					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TTGTCCACATCAAAAAAGTGA	0.418													13	29					0	0	0	0	T	209180091	T	T	209180091	2	4	145	1	0	0	0	0	0	0	0	1	11979	816	29	2		2	PIKFYVE	2	209180091	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	6604288	209180091	34019282	77	26497											
C2orf67	151050	broad.mit.edu	37	chr2	211018891	211018891	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcactggctcgtggtatctGatagaggctcctttttgatg	6	15	12	8	1	1	3	0	2	1	1	3	3	2	3	1	3	1	4	1	3	2	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:211018891G>C	uc002vds.2	-	2	624	c.416C>G	c.(415-417)TCA>TGA	p.S139*	C2orf67_uc002vdt.2_Nonsense_Mutation_p.S139*|C2orf67_uc002vdw.2_Nonsense_Mutation_p.S139*|C2orf67_uc002vdy.1_Nonsense_Mutation_p.S139*|C2orf67_uc002vdv.2_Nonsense_Mutation_p.S139*|C2orf67_uc002vdx.1_Nonsense_Mutation_p.S139*	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	139										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		CGTGGTATCTGATAGAGGCTC	0.343													5	73					0	0	0	0	C	211018891	C	C	211018891	4	2	145	1	0	0	0	0	0	1	0	0	2196	1294	45	2	2603	2	C2orf67	2	211018891	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1838800	211018891	32180482	78	26498											
MYL1	4632	broad.mit.edu	37	chr2	211163191	211163191	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcctgacctctgcattggtgGgatttgtgcccagagctcga	6	12	12	11	1	1	2	0	1	1	1	3	4	2	3	3	2	3	2	3	2	0	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:211163191G>C	uc002vec.2	-	3	386	c.257C>G	c.(256-258)CCC>CGC	p.P86R	MYL1_uc002veb.2_Missense_Mutation_p.P42R	NM_079420	NP_524144	P05976	MYL1_HUMAN	fast skeletal myosin alkali light chain 1	86					muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			ovary(1)	1				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		TGCATTGGTGGGATTTGTGCC	0.473													57	72					0	0	0	0	C	211163191	C	C	211163191	3	2	145	1	0	0	0	0	1	0	0	0	10096	1232	43	4	343	4	MYL1	2	211163191	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	144300	211163191	32036182	79	26499											
ERBB4	2066	broad.mit.edu	37	chr2	212589868	212589868	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatggcagcagtcactgacgTaaggtccgtagcatctgccg	9	8	13	11	3	2	1	1	1	1	0	3	2	3	1	2	2	3	5	2	2	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:212589868T>A	uc002veg.1	-	6	772	c.674A>T	c.(673-675)TAC>TTC	p.Y225F	ERBB4_uc002veh.1_Missense_Mutation_p.Y225F|ERBB4_uc010zji.1_Missense_Mutation_p.Y225F|ERBB4_uc010zjj.1_Missense_Mutation_p.Y225F|ERBB4_uc010fut.1_Missense_Mutation_p.Y225F	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	225	Cys-rich.|Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTCACTGACGTAAGGTCCGTA	0.493										TSP Lung(8;0.080)			41	47					0	0	0	0	A	212589868	A	A	212589868	3	1	145	1	0	0	0	0	1	0	0	0	5233	1638	57	5	3344	5	ERBB4	2	212589868	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	1426677	212589868	30609505	80	26500											
FN1	2335	broad.mit.edu	37	chr2	216269263	216269263	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgcctgggctgtcctcttcgGgtaaggcccacggtcagtcg	4	10	14	13	3	2	0	1	0	1	0	5	0	3	0	3	4	1	2	3	4	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:216269263G>A	uc002vfa.2	-	20	3368	c.3102C>T	c.(3100-3102)ACC>ACT	p.T1034T	FN1_uc002vfb.2_Silent_p.T1034T|FN1_uc002vfc.2_Silent_p.T1034T|FN1_uc002vfd.2_Silent_p.T1034T|FN1_uc002vfe.2_Silent_p.T1034T|FN1_uc002vff.2_Silent_p.T1034T|FN1_uc002vfg.2_Silent_p.T1034T|FN1_uc002vfh.2_Silent_p.T1034T|FN1_uc002vfi.2_Silent_p.T1034T|FN1_uc002vfj.2_Silent_p.T1034T	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1034	|Fibronectin type-III 5.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCCTCTTCGGGTAAGGCCCA	0.547													45	50					0	0	0	0	A	216269263	A	A	216269263	2	1	145	1	0	0	0	0	0	0	0	1	5994	1219	43	4		4	FN1	2	216269263	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3679395	216269263	26930110	81	26501											
RNPEPL1	57140	broad.mit.edu	37	chr2	241514540	241514540	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctctgcggagacccacagcGctttgatgactttctccgag	7	10	11	13	3	2	3	0	2	2	1	3	5	2	3	2	1	2	2	2	1	0	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:241514540G>A	uc002vzi.2	+	7	1282	c.689G>A	c.(688-690)CGC>CAC	p.R230H	RNPEPL1_uc010fzf.2_Missense_Mutation_p.R136H|RNPEPL1_uc002vzj.2_5'Flank	NM_018226	NP_060696	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like	230					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		GACCCACAGCGCTTTGATGAC	0.632													81	75					0	0	0	0	A	241514540	A	A	241514540	3	1	145	1	0	0	0	0	1	0	0	0	13575	1087	38	1	707	1	RNPEPL1	2	241514540	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	25245277	241514540	1684833	82	26502											
HDLBP	3069	broad.mit.edu	37	chr2	242187504	242187504	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggacaatgtcacttttttGtgctgggtctggaaagttaa	9	15	11	6	0	2	0	1	0	1	0	2	2	2	2	0	3	1	2	0	3	3	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:242187504G>T	uc002waz.2	-	14	1873	c.1645C>A	c.(1645-1647)CAA>AAA	p.Q549K	HDLBP_uc002wba.2_Missense_Mutation_p.Q549K|HDLBP_uc002wbb.2_Missense_Mutation_p.Q501K	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	549	KH 6.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TCACTTTTTTGTGCTGGGTCT	0.408													43	37					1.8453e-21	3.14579e-21	1	0	T	242187504	T	T	242187504	3	4	145	1	0	0	0	0	1	0	0	0	7064	1386	48	4	2221	4	HDLBP	2	242187504	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	672964	242187504	1011869	83	26503											
ITPR1	3708	broad.mit.edu	37	chr3	4829703	4829703	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tatgtgaattcctaaccaagGagtcaaaactacgaatttac	16	11	6	8	1	1	1	1	1	0	0	2	3	2	2	2	1	4	0	2	1	9	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:4829703G>A	uc003bqa.2	+	49	6892	c.6544G>A	c.(6544-6546)GAG>AAG	p.E2182K	ITPR1_uc010hca.1_Missense_Mutation_p.E2167K|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.E1152K	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2230	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CCTAACCAAGGAGTCAAAACT	0.388													5	38					0	0	0	0	A	4829703	A	A	4829703	3	1	145	1	0	0	0	0	1	0	0	0	7959	1175	41	2	6886	2	ITPR1	3	4829703	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08		4829703	193192727	84	26504											
SYN2	6854	broad.mit.edu	37	chr3	12208791	12208791	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctctgcgatgctggagcaGattgccatgtcagacaggtg	8	9	15	9	1	2	2	1	0	1	2	2	4	2	3	1	3	4	3	1	3	0	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:12208791G>C	uc003bwm.2	+	12	1202	c.1038G>C	c.(1036-1038)CAG>CAC	p.Q346H	SYN2_uc003bwl.1_Missense_Mutation_p.Q346H|SYN2_uc003bwn.2_Missense_Mutation_p.Q20H	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	346					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						TGCTGGAGCAGATTGCCATGT	0.517													6	31					0	0	0	0	C	12208791	C	C	12208791	3	2	145	1	0	0	0	0	1	0	0	0	15507	933	33	2	1069	2	SYN2	3	12208791	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	7379088	12208791	185813639	85	26505											
SLC4A7	9497	broad.mit.edu	37	chr3	27463267	27463267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttctcatgaaattcatatCaacctattgacaaataaata	17	15	2	7	0	3	2	3	2	1	0	4	2	3	2	1	0	1	0	1	0	8	8			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:27463267C>T	uc003cdv.2	-	9	1314	c.1243G>A	c.(1243-1245)GAT>AAT	p.D415N	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.D296N|SLC4A7_uc011aww.1_Missense_Mutation_p.D424N|SLC4A7_uc011awx.1_Missense_Mutation_p.D411N|SLC4A7_uc011awy.1_Missense_Mutation_p.D407N|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.D296N|SLC4A7_uc011axb.1_Missense_Mutation_p.D411N|SLC4A7_uc010hfl.2_Intron|SLC4A7_uc003cdw.2_Missense_Mutation_p.D291N	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	415	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						AAATTCATATCAACCTATTGA	0.353													50	33					0	0	0	0	T	27463267	T	T	27463267	3	4	145	1	0	0	0	0	1	0	0	0	14722	826	29	2	2469	2	SLC4A7	3	27463267	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	15254476	27463267	170559163	86	26506											
ANO10	55129	broad.mit.edu	37	chr3	43596801	43596801	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caatattggctgaaggttctGagaatggacgtttgaagacc	12	11	12	6	1	1	4	0	3	1	2	1	6	1	5	1	3	0	3	1	3	5	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:43596801G>C	uc003cmv.2	-	10	1808	c.1637C>G	c.(1636-1638)TCA>TGA	p.S546*	ANO10_uc011azs.1_Nonsense_Mutation_p.S546*|ANO10_uc003cmw.2_Nonsense_Mutation_p.S480*|ANO10_uc010hil.2_Nonsense_Mutation_p.S356*|ANO10_uc011azt.1_Nonsense_Mutation_p.S435*	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	546	Cytoplasmic (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						TGAAGGTTCTGAGAATGGACG	0.353													8	112					0	0	0	0	C	43596801	C	C	43596801	4	2	145	1	0	0	0	0	0	1	0	0	696	1294	45	2	361	2	ANO10	3	43596801	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	16133534	43596801	154425629	87	26507											
LTF	4057	broad.mit.edu	37	chr3	46482938	46482938	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaagacagtgacatctttCacaaatgcaacgtctccagc	13	9	7	12	1	3	2	1	1	2	1	4	2	3	2	1	0	4	2	1	0	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:46482938C>A	uc003cpq.2	-	14	1730	c.1692G>T	c.(1690-1692)GTG>GTT	p.V564V	LTF_uc003fzr.2_Silent_p.V520V|LTF_uc010hjh.2_Silent_p.V562V|LTF_uc003cpr.2_Silent_p.V551V	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	564	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	TGACATCTTTCACAAATGCAA	0.403													60	27					2.04494e-18	3.3582e-18	1	0	A	46482938	A	A	46482938	2	1	145	1	0	0	0	0	0	0	0	1	9129	813	29	2		2	LTF	3	46482938	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2886137	46482938	151539492	88	26508											
NBEAL2	23218	broad.mit.edu	37	chr3	47049354	47049354	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtggcatctacctcatctCaggctcccgggacaccacgt	7	9	9	16	2	3	0	2	0	2	0	5	1	4	1	3	3	1	2	3	3	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:47049354C>G	uc003cqp.2	+	49	7735	c.7556C>G	c.(7555-7557)TCA>TGA	p.S2519*	NBEAL2_uc010hjm.1_Nonsense_Mutation_p.S1896*|NBEAL2_uc010hjn.1_Nonsense_Mutation_p.S885*|NBEAL2_uc010hjo.1_Nonsense_Mutation_p.S79*	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2519	WD 3.						binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TACCTCATCTCAGGCTCCCGG	0.632													12	26					0	0	0	0	G	47049354	G	G	47049354	4	3	145	1	0	0	0	0	0	1	0	0	10242	838	29	2	7750	2	NBEAL2	3	47049354	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	566416	47049354	150973076	89	26509											
NBEAL2	23218	broad.mit.edu	37	chr3	47049787	47049787	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcaggatggaactgtgatCatacacactgtacgccgcgg	10	8	12	11	3	1	1	1	1	0	0	1	3	1	3	1	3	4	2	1	3	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:47049787C>G	uc003cqp.2	+	51	7913	c.7734C>G	c.(7732-7734)ATC>ATG	p.I2578M	NBEAL2_uc010hjm.1_Missense_Mutation_p.I1955M|NBEAL2_uc010hjn.1_Missense_Mutation_p.I944M|NBEAL2_uc010hjo.1_Missense_Mutation_p.I138M	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2578	WD 4.						binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GAACTGTGATCATACACACTG	0.602													9	27					0	0	0	0	G	47049787	G	G	47049787	3	3	145	1	0	0	0	0	1	0	0	0	10242	816	29	2	7936	2	NBEAL2	3	47049787	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	433	47049787	150972643	90	26510											
ZMYND10	51364	broad.mit.edu	37	chr3	50380755	50380755	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cacctgcatggggttgctgtCctgggatccctccccctcag	4	10	11	16	0	1	0	1	0	0	0	4	1	4	1	5	3	2	3	5	3	0	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:50380755C>G	uc003dag.1	-	5	639	c.493G>C	c.(493-495)GAC>CAC	p.D165H	RASSF1_uc003dad.1_5'Flank|RASSF1_uc003dae.1_5'Flank|RASSF1_uc010hlk.1_5'Flank|RASSF1_uc003daf.1_5'Flank|RASSF1_uc011bdq.1_5'Flank|ZMYND10_uc010hll.1_Missense_Mutation_p.D165H|ZMYND10_uc003dah.1_Missense_Mutation_p.D86H|ZMYND10_uc010hlm.1_Missense_Mutation_p.D122H	NM_015896	NP_056980	O75800	ZMY10_HUMAN	zinc finger, MYND domain-containing 10	165						cytoplasm	protein binding|zinc ion binding			lung(4)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGGTTGCTGTCCTGGGATCCC	0.617										TSP Lung(30;0.18)			21	51					0	0	0	0	G	50380755	G	G	50380755	3	3	145	1	0	0	0	0	1	0	0	0	17772	855	30	2	861	2	ZMYND10	3	50380755	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	3330968	50380755	147641675	91	26511											
LRIG1	26018	broad.mit.edu	37	chr3	66460596	66460596	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccagcccttgcggtgaaTgcgagcgatggaattgttgc	7	10	14	10	3	0	1	0	1	0	0	1	4	1	2	2	2	5	2	2	2	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:66460596T>C	uc003dmx.2	-	7	906	c.892A>G	c.(892-894)ATT>GTT	p.I298V	LRIG1_uc010hnz.2_Missense_Mutation_p.I38V|LRIG1_uc010hoa.2_Missense_Mutation_p.I298V	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	298	Extracellular (Potential).|LRR 10.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TTGCGGTGAATGCGAGCGATG	0.567													141	137					0	0	0	0	C	66460596	C	C	66460596	3	2	145	1	0	0	0	0	1	0	0	0	8994	1464	51	5	2441	5	LRIG1	3	66460596	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	16079841	66460596	131561834	92	26512											
FRMD4B	23150	broad.mit.edu	37	chr3	69239050	69239050	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggaagagccacttacgatCatcataggtggtggtgtcag	12	9	13	7	1	3	1	3	0	0	1	3	3	3	2	1	4	2	0	1	4	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:69239050C>T	uc003dnv.2	-	18	2058	c.1768G>A	c.(1768-1770)GAT>AAT	p.D590N	FRMD4B_uc003dnw.2_Intron|FRMD4B_uc003dnu.2_Missense_Mutation_p.D242N|FRMD4B_uc011bga.1_Missense_Mutation_p.D434N	NM_015123	NP_055938	Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	590						cytoplasm|cytoskeleton	binding			ovary(3)|central_nervous_system(1)	4		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		CACTTACGATCATCATAGGTG	0.313													16	27					0	0	0	0	T	69239050	T	T	69239050	3	4	145	1	0	0	0	0	1	0	0	0	6086	826	29	2	1360	2	FRMD4B	3	69239050	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2778454	69239050	128783380	93	26513											
OR5K3	403277	broad.mit.edu	37	chr3	98109533	98109533	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataaggagaatcactccttGatagctgagttcatcctcac	13	11	7	10	0	3	3	3	2	0	1	5	4	5	3	2	1	1	2	2	1	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:98109533G>C	uc011bgw.1	+	1	24	c.24G>C	c.(22-24)TTG>TTC	p.L8F		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATCACTCCTTGATAGCTGAGT	0.388													24	73					0	0	0	0	C	98109533	C	C	98109533	3	2	145	1	0	0	0	0	1	0	0	0	11222	1281	45	2	26	2	OR5K3	3	98109533	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	28870483	98109533	99912897	94	26514											
CD200R1	131450	broad.mit.edu	37	chr3	112647682	112647682	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaggaagtagctctatgtaCagactcttgttgccagtcaa	11	11	9	10	0	3	1	1	0	2	1	3	2	3	2	2	1	3	4	2	1	5	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:112647682C>A	uc003dzk.1	-	4	914	c.681G>T	c.(679-681)CTG>CTT	p.L227L	CD200R1_uc003dzj.1_Silent_p.L250L|CD200R1_uc011bhx.1_Silent_p.L205L	NM_170780	NP_740750	Q8TD46	MO2R1_HUMAN	CD200 receptor 1 isoform d	227	Ig-like C2-type.|Extracellular (Potential).				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(2)|pancreas(1)	3						GCTCTATGTACAGACTCTTGT	0.378													20	40					3.62473e-10	5.67901e-10	1	0	A	112647682	A	A	112647682	2	1	145	1	0	0	0	0	0	0	0	1	2996	465	17	4		4	CD200R1	3	112647682	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	14538149	112647682	85374748	95	26515											
TIGIT	201633	broad.mit.edu	37	chr3	114026751	114026751	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtttttagaagaaagccCtcagaatccattctgtggaa	12	14	8	7	0	2	3	1	0	1	3	3	4	3	4	2	1	1	1	2	1	5	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:114026751C>T	uc003ebg.1	+	4	542	c.508C>T	c.(508-510)CTC>TTC	p.L170F		NM_173799	NP_776160	Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	170	Cytoplasmic (Potential).				negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)	1						GAAGAAAGCCCTCAGAATCCA	0.418													21	111					0	0	0	0	T	114026751	T	T	114026751	3	4	145	1	0	0	0	0	1	0	0	0	15968	681	24	4	522	4	TIGIT	3	114026751	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1379069	114026751	83995679	96	26516											
CASR	846	broad.mit.edu	37	chr3	122003103	122003103	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcttcatcacgtgccacgagGgctccctcatggccctgggc	5	9	11	16	2	4	0	3	0	1	0	5	1	5	0	3	3	1	1	3	3	0	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:122003103G>T	uc003eev.3	+	7	2674	c.2302G>T	c.(2302-2304)GGC>TGC	p.G768C	CASR_uc003eew.3_Missense_Mutation_p.G778C	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	768	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GTGCCACGAGGGCTCCCTCAT	0.587													22	44					1.10513e-12	1.77019e-12	1	0	T	122003103	T	T	122003103	3	4	145	1	0	0	0	0	1	0	0	0	2694	1232	43	4	2354	4	CASR	3	122003103	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	7976352	122003103	76019327	97	26517											
KALRN	8997	broad.mit.edu	37	chr3	124390618	124390618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccctactcctctgttcctgCgggctcagagaagcccccaa	7	8	9	17	1	2	1	1	0	1	1	4	2	4	1	5	1	3	2	5	1	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:124390618C>T	uc003ehg.2	+	48	6939	c.6812C>T	c.(6811-6813)GCG>GTG	p.A2271V	KALRN_uc003ehi.2_Missense_Mutation_p.A612V|KALRN_uc003ehk.2_Missense_Mutation_p.A574V|KALRN_uc011bjz.1_Missense_Mutation_p.A363V	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2270					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TCTGTTCCTGCGGGCTCAGAG	0.567													20	151					0	0	0	0	T	124390618	T	T	124390618	3	4	145	1	0	0	0	0	1	0	0	0	8014	768	27	1	7158	1	KALRN	3	124390618	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2387515	124390618	73631812	98	26518											
CLRN1	7401	broad.mit.edu	37	chr3	150690259	150690259	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttacatgagaaccgaaagggCcttgctcccaacccacactg	12	7	8	14	1	0	1	0	1	0	1	1	3	1	1	4	1	4	1	4	1	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:150690259C>T	uc003eyk.1	-	1	528	c.237G>A	c.(235-237)AGG>AGA	p.R79R	CLRN1OS_uc011bny.1_Intron|CLRN1OS_uc003eyl.2_5'Flank	NM_174878	NP_777367	P58418	CLRN1_HUMAN	clarin 1 isoform a	79					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			ACCGAAAGGGCCTTGCTCCCA	0.473													56	164					0	0	0	0	T	150690259	T	T	150690259	2	4	145	1	0	0	0	0	0	0	0	1	3572	738	26	4		4	CLRN1	3	150690259	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	26299641	150690259	47332171	99	26519											
IFT80	57560	broad.mit.edu	37	chr3	160099294	160099294	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttatttaaaacttaccatCagaacttgtgaggacaaagc	15	12	7	7	0	1	2	1	1	0	1	1	3	1	3	1	1	4	1	1	1	6	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:160099294C>G	uc011boy.1	-	3	689	c.256G>C	c.(256-258)GAT>CAT	p.D86H	IFT80_uc003fda.2_Intron|IFT80_uc003fdb.1_5'UTR|IFT80_uc003fdd.1_5'UTR|IFT80_uc003fde.1_5'UTR	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	86						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AACTTACCATCAGAACTTGTG	0.328													15	106					0	0	0	0	G	160099294	G	G	160099294	3	3	145	1	0	0	0	0	1	0	0	0	7603	826	29	2	2149	2	IFT80	3	160099294	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	9409035	160099294	37923136	100	26520											
SMC4	10051	broad.mit.edu	37	chr3	160120573	160120573	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aataagatctaaaaaactctCagtattaatacataattctg	19	13	3	6	0	3	1	1	0	3	1	4	1	3	1	0	0	2	1	0	0	9	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:160120573C>A	uc003fdh.2	+	4	541	c.428C>A	c.(427-429)TCA>TAA	p.S143*	IFT80_uc003fda.2_Intron|SMC4_uc003fdf.1_RNA|SMC4_uc003fdg.1_Nonsense_Mutation_p.S143*|SMC4_uc010hwc.1_Intron|SMC4_uc003fdi.2_Nonsense_Mutation_p.S118*|SMC4_uc003fdj.2_Nonsense_Mutation_p.S143*|SMC4_uc010hwd.2_Nonsense_Mutation_p.S143*|uc011boz.1_5'Flank|MIR15B_hsa-mir-15b|MI0000438_5'Flank|uc003fdk.2_5'Flank|MIR16-2_hsa-mir-16-2|MI0000115_5'Flank	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	143					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AAAAAACTCTCAGTATTAATA	0.323													8	262					0.000274275	0.000403246	1	0	A	160120573	A	A	160120573	4	1	145	1	0	0	0	0	0	1	0	0	14849	838	29	2	438	2	SMC4	3	160120573	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	21279	160120573	37901857	101	26521											
MYNN	55892	broad.mit.edu	37	chr3	169492266	169492266	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcacttctgagaacaatgtCtttcttgatcagagtcaggt	11	13	9	8	0	5	3	2	2	3	2	5	4	5	3	0	1	2	1	0	1	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:169492266C>G	uc003fft.2	+	2	612	c.183C>G	c.(181-183)GTC>GTG	p.V61V	MYNN_uc011bpm.1_Intron|MYNN_uc003ffu.2_Silent_p.V61V|MYNN_uc003ffv.2_5'UTR|MYNN_uc010hwo.2_Silent_p.V61V	NM_018657	NP_061127	Q9NPC7	MYNN_HUMAN	myoneurin	61	BTB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			AGAACAATGTCTTTCTTGATC	0.388													5	380					0	0	0	0	G	169492266	G	G	169492266	2	3	145	1	0	0	0	0	0	0	0	1	10114	900	32	2		2	MYNN	3	169492266	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	9371693	169492266	28530164	102	26522											
NAALADL2	254827	broad.mit.edu	37	chr3	174814867	174814867	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgactacattacccattatAcacgatctgcaccaaagagc	14	9	5	13	1	1	2	0	1	1	1	1	3	1	2	2	0	5	1	2	0	5	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:174814867A>T	uc003fit.2	+	2	418	c.331A>T	c.(331-333)ACA>TCA	p.T111S	NAALADL2_uc003fiu.1_Missense_Mutation_p.T104S	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	111	Cytoplasmic (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TACCCATTATACACGATCTGC	0.388													58	233					0	0	0	0	T	174814867	T	T	174814867	3	4	145	1	0	0	0	0	1	0	0	0	10183	391	14	5	337	5	NAALADL2	3	174814867	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	5322601	174814867	23207563	103	26523											
NAALADL2	254827	broad.mit.edu	37	chr3	174951960	174951960	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagccaagacctgctctattCatatgcagcctattctgcca	10	11	6	14	0	3	1	1	0	2	1	3	1	3	1	4	0	5	2	4	0	4	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:174951960C>T	uc003fit.2	+	3	872	c.785C>T	c.(784-786)TCA>TTA	p.S262L	NAALADL2_uc003fiu.1_Missense_Mutation_p.S255L|NAALADL2_uc010hwy.1_Missense_Mutation_p.S84L	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	262	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		CTGCTCTATTCATATGCAGCC	0.428													26	146					0	0	0	0	T	174951960	T	T	174951960	3	4	145	1	0	0	0	0	1	0	0	0	10183	838	29	2	795	2	NAALADL2	3	174951960	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	137093	174951960	23070470	104	26524											
PIK3CA	5290	broad.mit.edu	37	chr3	178921521	178921521	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttataaatagtgcactcAgaataaaaattctttgtgca	15	13	8	5	0	2	1	1	0	1	1	2	1	2	1	0	1	2	3	0	1	8	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:178921521A>G	uc003fjk.2	+	5	1160	c.1003A>G	c.(1003-1005)AGA>GGA	p.R335G		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	335					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TAGTGCACTCAGAATAAAAAT	0.313		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			40	317					0	0	0	0	G	178921521	G	G	178921521	3	3	145	1	0	0	0	0	1	0	0	0	11968	180	7	5	1017	5	PIK3CA	3	178921521	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	3969561	178921521	19100909	105	26525											
MCCC1	56922	broad.mit.edu	37	chr3	182790247	182790247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcaaattccatgttttctGagagaaaaccgcatcctgga	13	10	8	10	1	1	2	0	1	1	1	3	4	3	3	3	1	2	3	3	1	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:182790247G>A	uc003fle.2	-	5	535	c.398C>T	c.(397-399)TCA>TTA	p.S133L	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Intron|MCCC1_uc003flg.2_Missense_Mutation_p.S24L|MCCC1_uc011bqp.1_Missense_Mutation_p.S86L|MCCC1_uc011bqq.1_Missense_Mutation_p.S24L	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	133	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	CATGTTTTCTGAGAGAAAACC	0.383													14	228					0	0	0	0	A	182790247	A	A	182790247	3	1	145	1	0	0	0	0	1	0	0	0	9427	1294	45	2	1839	2	MCCC1	3	182790247	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3868726	182790247	15232183	106	26526											
PAK2	5062	broad.mit.edu	37	chr3	196509690	196509690	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaatcatctccatattctCaggcacagagaaaggtaaat	17	10	6	8	0	3	1	2	0	2	1	5	2	3	1	1	2	0	2	1	2	6	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:196509690C>T	uc003fwy.3	+	2	495	c.173C>T	c.(172-174)TCA>TTA	p.S58L		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	58					axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		TCCATATTCTCAGGCACAGAG	0.413													32	377					0	0	0	0	T	196509690	T	T	196509690	3	4	145	1	0	0	0	0	1	0	0	0	11455	838	29	2	175	2	PAK2	3	196509690	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	13719443	196509690	1512740	107	26527											
DLG1	1739	broad.mit.edu	37	chr3	196846384	196846384	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgggctaacatggttatCaacaggctgagaagaagctt	14	9	12	6	0	1	3	1	1	0	3	1	4	1	3	0	3	3	4	0	3	5	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:196846384C>G	uc003fxo.3	-	13	1472	c.1282G>C	c.(1282-1284)GAT>CAT	p.D428H	DLG1_uc011bub.1_Missense_Mutation_p.D312H|DLG1_uc011buc.1_Missense_Mutation_p.D312H|DLG1_uc011bud.1_Missense_Mutation_p.D111H|DLG1_uc003fxn.3_Missense_Mutation_p.D428H|DLG1_uc011bue.1_Missense_Mutation_p.D395H|DLG1_uc010ial.2_Missense_Mutation_p.D428H|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Missense_Mutation_p.D395H|DLG1_uc010ian.2_Missense_Mutation_p.D295H	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	428					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		ACATGGTTATCAACAGGCTGA	0.388													13	146					0	0	0	0	G	196846384	G	G	196846384	3	3	145	1	0	0	0	0	1	0	0	0	4576	826	29	2	1592	2	DLG1	3	196846384	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	336694	196846384	1176046	108	26528											
LPHN3	23284	broad.mit.edu	37	chr4	62778453	62778453	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcagcttcagaaaagagagcGctcttgcagagcctatgtcc	11	9	10	11	1	3	3	2	0	1	3	4	4	4	3	2	0	4	3	2	0	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:62778453G>A	uc010ihh.2	+	10	2059	c.1886G>A	c.(1885-1887)CGC>CAC	p.R629H	LPHN3_uc003hcq.3_Missense_Mutation_p.R629H|LPHN3_uc003hct.2_Intron|LPHN3_uc003hcs.1_Intron	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AAAAGAGAGCGCTCTTGCAGA	0.363													50	51					0	0	0	0	A	62778453	A	A	62778453	3	1	145	1	0	0	0	0	1	0	0	0	8967	1087	38	1	1924	1	LPHN3	4	62778453	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08		62778453	128375823	109	26529											
SLC4A4	8671	broad.mit.edu	37	chr4	72205125	72205125	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatccgattcatcttgggaGaggaggatgacagcccagct	10	8	13	10	1	2	2	1	1	1	1	3	6	3	4	2	3	2	2	2	3	0	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:72205125G>C	uc003hfy.2	+	4	409	c.292G>C	c.(292-294)GAG>CAG	p.E98Q	SLC4A4_uc010iic.2_Missense_Mutation_p.E98Q|SLC4A4_uc010iib.2_Missense_Mutation_p.E98Q|SLC4A4_uc003hfz.2_Missense_Mutation_p.E98Q|SLC4A4_uc003hgc.3_Missense_Mutation_p.E54Q|SLC4A4_uc003hga.2_5'UTR|SLC4A4_uc003hgb.3_Missense_Mutation_p.E54Q	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	98	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CATCTTGGGAGAGGAGGATGA	0.552													23	212					0	0	0	0	C	72205125	C	C	72205125	3	2	145	1	0	0	0	0	1	0	0	0	14720	943	33	2	423	2	SLC4A4	4	72205125	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	9426672	72205125	118949151	110	26530											
ADAMTS3	9508	broad.mit.edu	37	chr4	73280591	73280591	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttctacagctgatctcttgTagacaacatgaatccttcct	10	14	6	11	0	2	3	0	2	2	1	5	3	4	3	2	0	3	3	2	0	4	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:73280591T>A	uc003hgk.1	-	4	639	c.602A>T	c.(601-603)TAC>TTC	p.Y201F		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	201					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGATCTCTTGTAGACAACATG	0.373													44	48					0	0	0	0	A	73280591	A	A	73280591	3	1	145	1	0	0	0	0	1	0	0	0	267	1638	57	5	3091	5	ADAMTS3	4	73280591	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	1075466	73280591	117873685	111	26531											
FRAS1	80144	broad.mit.edu	37	chr4	79285132	79285132	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcctcatgtgacaccaacctCgtgctgtcccacactggcac	8	9	7	17	1	1	1	1	1	0	0	4	1	3	1	4	1	2	2	4	1	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:79285132C>G	uc003hlb.2	+	22	3086	c.2646C>G	c.(2644-2646)CTC>CTG	p.L882L	FRAS1_uc003hkw.2_Silent_p.L882L	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	882	FU 10.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ACACCAACCTCGTGCTGTCCC	0.527													4	29					0	0	0	0	G	79285132	G	G	79285132	2	3	145	1	0	0	0	0	0	0	0	1	6076	871	31	3		3	FRAS1	4	79285132	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	6004541	79285132	111869144	112	26532											
DMP1	1758	broad.mit.edu	37	chr4	88584164	88584164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcgaatccagtgagagcCtcaacttctcagaggaaagc	14	6	10	11	1	2	2	2	1	1	2	4	5	3	3	2	1	4	0	2	1	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:88584164C>T	uc003hqv.2	+	6	1338	c.1234C>T	c.(1234-1236)CTC>TTC	p.L412F	DMP1_uc003hqw.2_Missense_Mutation_p.L396F	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	412					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CAGTGAGAGCCTCAACTTCTC	0.572													58	59					0	0	0	0	T	88584164	T	T	88584164	3	4	145	1	0	0	0	0	1	0	0	0	4605	681	24	4	1252	4	DMP1	4	88584164	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	9299032	88584164	102570112	113	26533											
CENPE	1062	broad.mit.edu	37	chr4	104068734	104068734	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taataactccagttcattcaTtgtttcctgagtctcactga	10	16	5	10	0	3	2	3	2	1	0	6	2	5	2	2	0	1	2	2	0	2	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:104068734T>C	uc003hxb.1	-	29	4003	c.3913A>G	c.(3913-3915)ATG>GTG	p.M1305V	CENPE_uc003hxc.1_Missense_Mutation_p.M1280V	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1305	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		AGTTCATTCATTGTTTCCTGA	0.388													44	40					0	0	0	0	C	104068734	C	C	104068734	3	2	145	1	0	0	0	0	1	0	0	0	3245	1493	52	5	4276	5	CENPE	4	104068734	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	15484570	104068734	87085542	114	26534											
COL25A1	84570	broad.mit.edu	37	chr4	109822296	109822296	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaggtcctggtattccattCtgtcctactgctccaggcaa	7	14	8	12	0	1	0	0	0	1	0	5	0	5	0	4	3	2	3	4	3	4	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:109822296C>T	uc003hze.1	-	13	1344	c.813G>A	c.(811-813)CAG>CAA	p.Q271Q	COL25A1_uc003hzg.2_Silent_p.Q271Q|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Silent_p.Q52Q	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	271	Extracellular (Potential).|Collagen-like 3.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		GTATTCCATTCTGTCCTACTG	0.348													15	50					0	0	0	0	T	109822296	T	T	109822296	2	4	145	1	0	0	0	0	0	0	0	1	3699	912	32	2		2	COL25A1	4	109822296	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	5753562	109822296	81331980	115	26535											
KIAA1109	84162	broad.mit.edu	37	chr4	123155982	123155982	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aataagaggtgtagaaacaaAtgtggttgtctcggtggctg	12	11	14	4	1	1	2	0	0	1	2	2	2	1	2	0	4	1	3	0	4	5	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:123155982A>G	uc003ieh.2	+	25	3423	c.3378A>G	c.(3376-3378)AAA>AAG	p.K1126K	KIAA1109_uc003iei.1_Silent_p.K879K|KIAA1109_uc010ins.1_Silent_p.K469K	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1126					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GTAGAAACAAATGTGGTTGTC	0.393													50	54					0	0	0	0	G	123155982	G	G	123155982	2	3	145	1	0	0	0	0	0	0	0	1	8247	98	4	5		5	KIAA1109	4	123155982	Silent	SNP	A	TCGA-CR-7374-01A-11D-2012-08	13333686	123155982	67998294	116	26536											
SPATA5	166378	broad.mit.edu	37	chr4	123855336	123855336	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcaagtattgcgagtgaaagGggcagatggcatgatattgg	12	9	16	4	1	0	3	0	2	0	1	0	4	0	3	0	4	1	4	0	4	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:123855336G>T	uc003iez.3	+	5	663	c.590G>T	c.(589-591)GGG>GTG	p.G197V	SPATA5_uc003iey.2_Missense_Mutation_p.G196V	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	197					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						CGAGTGAAAGGGGCAGATGGC	0.463													30	42					1.80694e-10	2.84972e-10	1	0	T	123855336	T	T	123855336	3	4	145	1	0	0	0	0	1	0	0	0	15077	1232	43	4	608	4	SPATA5	4	123855336	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	699354	123855336	67298940	117	26537											
HSPA4L	22824	broad.mit.edu	37	chr4	128741604	128741604	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctgtctcagacaaacaaGaccgattaaatcagacactt	16	8	6	11	1	2	3	2	0	1	3	3	4	2	3	1	0	2	1	1	0	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:128741604G>C	uc003ifm.2	+	14	1949	c.1696G>C	c.(1696-1698)GAC>CAC	p.D566H	HSPA4L_uc010iny.1_Missense_Mutation_p.D525H|HSPA4L_uc011cgr.1_Missense_Mutation_p.D533H	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	566					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						AGACAAACAAGACCGATTAAA	0.338													14	27					0	0	0	0	C	128741604	C	C	128741604	3	2	145	1	0	0	0	0	1	0	0	0	7452	942	33	2	1750	2	HSPA4L	4	128741604	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4886268	128741604	62412672	118	26538											
HSPA4L	22824	broad.mit.edu	37	chr4	128743942	128743942	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggaagatgatcatgcaaGataagttagagaaagaaaga	20	6	13	2	0	1	6	1	1	0	5	1	8	1	7	0	2	1	2	0	2	6	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:128743942G>T	uc003ifm.2	+	15	2084	c.1831G>T	c.(1831-1833)GAT>TAT	p.D611Y	HSPA4L_uc011cgr.1_Missense_Mutation_p.D578Y	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	611					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GATCATGCAAGATAAGTTAGA	0.274													16	26					4.7546e-09	7.36861e-09	1	0	T	128743942	T	T	128743942	3	4	145	1	0	0	0	0	1	0	0	0	7452	942	33	2	1889	2	HSPA4L	4	128743942	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2338	128743942	62410334	119	26539											
HSPA4L	22824	broad.mit.edu	37	chr4	128748493	128748493	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctattcaaatgaagtacatgGagcatgaagagagaccaaaa	19	7	9	6	0	1	4	1	2	0	2	1	6	1	5	1	1	2	2	1	1	7	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:128748493G>C	uc003ifm.2	+	17	2333	c.2080G>C	c.(2080-2082)GAG>CAG	p.E694Q	HSPA4L_uc011cgr.1_Missense_Mutation_p.E661Q	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	694					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GAAGTACATGGAGCATGAAGA	0.318													21	53					0	0	0	0	C	128748493	C	C	128748493	3	2	145	1	0	0	0	0	1	0	0	0	7452	1175	41	2	2146	2	HSPA4L	4	128748493	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4551	128748493	62405783	120	26540											
MFSD8	256471	broad.mit.edu	37	chr4	128865017	128865017	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctgccacggaaatcaagatgGagacaataagaggctctttt	14	9	10	8	1	2	3	1	0	1	3	2	5	2	4	1	3	1	1	1	3	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:128865017G>C	uc003ifp.2	-	5	492	c.329C>G	c.(328-330)TCC>TGC	p.S110C	MFSD8_uc011cgu.1_Missense_Mutation_p.S65C|MFSD8_uc011cgv.1_Missense_Mutation_p.S110C|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_Missense_Mutation_p.S65C	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	110	Helical; (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						AATCAAGATGGAGACAATAAG	0.423													3	75					0	0	0	0	C	128865017	C	C	128865017	3	2	145	1	0	0	0	0	1	0	0	0	9591	1174	41	2	1263	2	MFSD8	4	128865017	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	116524	128865017	62289259	121	26541											
NPY1R	4886	broad.mit.edu	37	chr4	164247211	164247211	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcaaagaagaagccacagCaaggacccaaatcacagcaa	20	1	9	11	0	1	2	1	0	0	2	1	3	1	3	2	2	3	3	2	2	6	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:164247211C>T	uc003iqm.1	-	2	762	c.496G>A	c.(496-498)GCT>ACT	p.A166T	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	166	Helical; Name=4; (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GAAGCCACAGCAAGGACCCAA	0.433													30	39					0	0	0	0	T	164247211	T	T	164247211	3	4	145	1	0	0	0	0	1	0	0	0	10662	710	25	4	666	4	NPY1R	4	164247211	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	35382194	164247211	26907065	122	26542											
GPM6A	2823	broad.mit.edu	37	chr4	176573001	176573001	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccaaactgacgaaggtcCaagcagagatttgctccctc	12	9	8	12	1	0	2	0	1	0	1	3	4	2	2	3	1	4	2	3	1	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:176573001C>T	uc003iuf.2	-	4	1329	c.525G>A	c.(523-525)TTG>TTA	p.L175L	GPM6A_uc011ckj.1_Silent_p.L168L|GPM6A_uc003iug.2_Silent_p.L175L|GPM6A_uc003iuh.2_Silent_p.L164L	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	175	Extracellular (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		GACGAAGGTCCAAGCAGAGAT	0.438													10	141					0	0	0	0	T	176573001	T	T	176573001	2	4	145	1	0	0	0	0	0	0	0	1	6653	593	21	4		4	GPM6A	4	176573001	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	12325790	176573001	14581275	123	26543											
FAT1	2195	broad.mit.edu	37	chr4	187521277	187521277	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acttcttccatgccttgttcCctgctgacggatgtggccac	5	13	9	14	1	1	1	0	1	1	0	3	2	3	2	4	2	2	2	4	2	0	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:187521277C>A	uc003izf.2	-	22	12066	c.11878G>T	c.(11878-11880)GGA>TGA	p.G3960*	FAT1_uc003ize.2_5'Flank	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3960	Extracellular (Potential).|Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGCCTTGTTCCCTGCTGACGG	0.483										HNSCC(5;0.00058)			60	70					6.09941e-20	1.02516e-19	1	0	A	187521277	A	A	187521277	4	1	145	1	0	0	0	0	0	1	0	0	5721	632	22	4	1912	4	FAT1	4	187521277	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	10948276	187521277	3632999	124	26544											
SEMA5A	9037	broad.mit.edu	37	chr5	9066745	9066745	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caggacacgggttggtgttgCaagactggtactcctgggga	8	9	16	8	1	0	1	0	0	0	1	1	3	1	3	1	6	2	4	1	6	2	3	rs140646095		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:9066745C>A	uc003jek.2	-	17	2799	c.2087G>T	c.(2086-2088)TGC>TTC	p.C696F		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	696	TSP type-1 3.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GTTGGTGTTGCAAGACTGGTA	0.537													78	178					4.63251e-29	8.18982e-29	1	0	A	9066745	A	A	9066745	3	1	145	1	0	0	0	0	1	0	0	0	14102	710	25	4	1165	4	SEMA5A	5	9066745	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08		9066745	171848515	125	26545											
CTNND2	1501	broad.mit.edu	37	chr5	11023077	11023077	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagcctgtggactaggtctcGcatggcgtatttgcctggaa	8	11	13	9	2	1	0	0	0	1	0	2	2	1	2	2	4	2	2	2	4	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:11023077G>A	uc003jfa.1	-	17	2948	c.2803C>T	c.(2803-2805)CGA>TGA	p.R935*	CTNND2_uc010itt.2_Nonsense_Mutation_p.R844*|CTNND2_uc011cmy.1_Nonsense_Mutation_p.R598*|CTNND2_uc011cmz.1_Nonsense_Mutation_p.R502*|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Nonsense_Mutation_p.R527*	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	935					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						ACTAGGTCTCGCATGGCGTAT	0.512													63	74					0	0	0	0	A	11023077	A	A	11023077	4	1	145	1	0	0	0	0	0	1	0	0	4037	1095	38	1	898	1	CTNND2	5	11023077	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1956332	11023077	169892183	126	26546											
CTNND2	1501	broad.mit.edu	37	chr5	11346514	11346514	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgaatgctatcaatggacGgggacctggccaaggtgcct	9	9	13	10	1	2	1	1	1	1	0	2	3	2	3	3	5	2	1	3	5	4	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:11346514G>T	uc003jfa.1	-	9	1743	c.1598C>A	c.(1597-1599)CCG>CAG	p.P533Q	CTNND2_uc010itt.2_Missense_Mutation_p.P442Q|CTNND2_uc011cmy.1_Missense_Mutation_p.P196Q|CTNND2_uc011cmz.1_Missense_Mutation_p.P100Q|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.P100Q	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	533					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						ATCAATGGACGGGGACCTGGC	0.493													105	163					3.00942e-58	5.67038e-58	1	0	T	11346514	T	T	11346514	3	4	145	1	0	0	0	0	1	0	0	0	4037	1116	39	3	2135	3	CTNND2	5	11346514	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	323437	11346514	169568746	127	26547											
MYO10	4651	broad.mit.edu	37	chr5	16783479	16783479	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcgttcaacacaggatgtCttctcctttaaggacaattc	10	13	7	11	1	3	0	1	0	2	0	6	2	3	2	1	2	1	2	1	2	3	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:16783479C>A	uc003jft.3	-	5	1035	c.567G>T	c.(565-567)AAG>AAT	p.K189N	MYO10_uc003jfu.2_Missense_Mutation_p.K156N	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	189	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CACAGGATGTCTTCTCCTTTA	0.378													9	23					1.76689e-08	2.7148e-08	1	0	A	16783479	A	A	16783479	3	1	145	1	0	0	0	0	1	0	0	0	10115	912	32	2	5757	2	MYO10	5	16783479	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	5436965	16783479	164131781	128	26548											
CDH9	1007	broad.mit.edu	37	chr5	26890642	26890642	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgagtgaataccaaaaatacGgtccatatcagtatgccgat	15	10	8	8	2	1	2	1	2	0	0	2	3	2	2	3	1	3	1	3	1	7	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:26890642G>T	uc003jgs.1	-	8	1454	c.1285C>A	c.(1285-1287)CGT>AGT	p.R429S	CDH9_uc011cnv.1_Missense_Mutation_p.R22S	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	429	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CCAAAAATACGGTCCATATCA	0.403													33	92					1.414e-09	2.20092e-09	1	0	T	26890642	T	T	26890642	3	4	145	1	0	0	0	0	1	0	0	0	3132	1116	39	3	1104	3	CDH9	5	26890642	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	10107163	26890642	154024618	129	26549											
AGXT2	64902	broad.mit.edu	37	chr5	35039554	35039554	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggtttctggaaatatgcCgtcaccacaggagaaagatg	13	8	13	7	1	2	2	1	0	1	2	2	4	2	3	2	4	1	1	2	4	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:35039554C>T	uc003jjf.2	-	3	316	c.237G>A	c.(235-237)ACG>ACA	p.T79T	AGXT2_uc011com.1_Silent_p.T79T|AGXT2_uc011con.1_5'UTR	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	79					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GGAAATATGCCGTCACCACAG	0.473													38	102					0	0	0	0	T	35039554	T	T	35039554	2	4	145	1	0	0	0	0	0	0	0	1	405	639	23	1		1	AGXT2	5	35039554	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	8148912	35039554	145875706	130	26550											
HEATR7B2	133558	broad.mit.edu	37	chr5	41055916	41055916	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcattattacttcttacttGttcatcaaaaaattccatca	13	18	1	9	0	5	0	4	0	1	0	6	0	6	0	1	0	2	1	1	0	6	8			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:41055916G>T	uc003jmj.3	-	10	1451	c.961C>A	c.(961-963)CAA>AAA	p.Q321K	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	321	HEAT 4.						binding			ovary(6)|central_nervous_system(2)	8						CTTCTTACTTGTTCATCAAAA	0.403													35	122					9.78485e-24	1.70461e-23	1	0	T	41055916	T	T	41055916	3	4	145	1	0	0	0	0	1	0	0	0	7074	1386	48	4	3928	4	HEATR7B2	5	41055916	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	6016362	41055916	139859344	131	26551											
FST	10468	broad.mit.edu	37	chr5	52778754	52778754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgaagaacggccgctgccagGtcctgtacaagaccgaactg	11	5	12	13	4	0	2	0	0	0	2	1	4	1	2	4	2	4	2	4	2	5	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:52778754G>A	uc003jpd.2	+	2	157	c.130G>A	c.(130-132)GTC>ATC	p.V44I	FST_uc003jpc.2_Missense_Mutation_p.V44I	NM_013409	NP_037541	P19883	FST_HUMAN	follistatin isoform FST344 precursor	44	TB.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of follicle-stimulating hormone secretion|negative regulation of transcription from RNA polymerase II promoter|positive regulation of hair follicle development	extracellular region	activin binding|protein binding|signal transducer activity				0		Ovarian(174;1.78e-06)|Lung NSC(810;3.55e-06)|Breast(144;4.08e-05)				CCGCTGCCAGGTCCTGTACAA	0.617											OREG0016608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	61					0	0	0	0	A	52778754	A	A	52778754	3	1	145	1	0	0	0	0	1	0	0	0	6110	1261	44	4	136	4	FST	5	52778754	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	11722838	52778754	128136506	132	26552											
MAP1B	4131	broad.mit.edu	37	chr5	71501008	71501008	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caacatcatggttttagcaaGcagcagcacagtggttatgc	12	10	10	9	0	1	0	1	0	0	0	1	0	1	0	0	2	6	6	0	2	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:71501008G>A	uc003kbw.3	+	7	7590	c.7349G>A	c.(7348-7350)AGC>AAC	p.S2450N		NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2450						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GTTTTAGCAAGCAGCAGCACA	0.468													10	211					0	0	0	0	A	71501008	A	A	71501008	3	1	145	1	0	0	0	0	1	0	0	0	9281	971	34	4	7375	4	MAP1B	5	71501008	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	18722254	71501008	109414252	133	26553											
AP3B1	8546	broad.mit.edu	37	chr5	77311320	77311320	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacagagggagtgaaattCtgtggtgcagcaatgattac	13	10	12	6	0	2	3	1	2	1	1	2	4	2	4	0	2	3	2	0	2	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:77311320C>A	uc003kfj.2	-	26	3170	c.3045G>T	c.(3043-3045)CAG>CAT	p.Q1015H		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	1015					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		GAGTGAAATTCTGTGGTGCAG	0.393									Hermansky-Pudlak_syndrome				74	34					2.0493e-37	3.73358e-37	1	0	A	77311320	A	A	77311320	3	1	145	1	0	0	0	0	1	0	0	0	744	912	32	2	247	2	AP3B1	5	77311320	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	5810312	77311320	103603940	134	26554											
ACOT12	134526	broad.mit.edu	37	chr5	80640770	80640770	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccttatcatcagcagcattGtaaatgagaaaagcactgtt	14	12	7	8	0	2	1	2	1	0	1	3	2	3	1	1	0	3	5	1	0	5	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:80640770G>A	uc003khl.3	-	8	919	c.864C>T	c.(862-864)TAC>TAT	p.Y288Y	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	288	Acyl coenzyme A hydrolase 2.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		CAGCAGCATTGTAAATGAGAA	0.488													49	118					0	0	0	0	A	80640770	A	A	80640770	2	1	145	1	0	0	0	0	0	0	0	1	150	1372	48	4		4	ACOT12	5	80640770	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3329450	80640770	100274490	135	26555											
GPR98	84059	broad.mit.edu	37	chr5	90106677	90106677	+	Silent	SNP	T	A	A																															acccttcatggcacacctgcTgtgtctgaaaagcctgatgt																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:90106677T>A	uc003kju.2	+	74	15696	c.15600T>A	c.(15598-15600)GCT>GCA	p.A5200A	GPR98_uc003kjt.2_Silent_p.A2906A|GPR98_uc003kjw.2_Silent_p.A861A	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5200	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCACACCTGCTGTGTCTGAAA	0.478													55	116					0	0	0	0	A	90106677	A	A	90106677	2	1	145	1	0	0	0	0	0	0	0	1	6760	1567	55	5		5	GPR98	5	90106677	Silent	SNP	T	TCGA-CR-7374-01A-11D-2012-08	9465907	90106677	90808583	136	26556	52	2									
GPR98	84059	broad.mit.edu	37	chr5	90106682	90106682	+	Missense_Mutation	SNP	C	A	A																															tcatggcacacctgctgtgtCtgaaaagcctgatgtggcca																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:90106682C>A	uc003kju.2	+	74	15701	c.15605C>A	c.(15604-15606)TCT>TAT	p.S5202Y	GPR98_uc003kjt.2_Missense_Mutation_p.S2908Y|GPR98_uc003kjw.2_Missense_Mutation_p.S863Y	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5202	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCTGCTGTGTCTGAAAAGCCT	0.468													57	111					3.31993e-32	5.97253e-32	1	0	A	90106682	A	A	90106682	3	1	145	1	0	0	0	0	1	0	0	0	6760	913	32	2	15899	2	GPR98	5	90106682	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	5	90106682	90808578	137	26557	52	2									
NUDT12	83594	broad.mit.edu	37	chr5	102890447	102890447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaaatggcttaccaggctCaataaatccagcaaggcaag	17	6	9	9	0	1	1	1	0	0	1	2	1	2	1	2	3	2	4	2	3	8	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:102890447C>T	uc003koi.2	-	5	1165	c.1072G>A	c.(1072-1074)GAG>AAG	p.E358K	NUDT12_uc011cvb.1_Missense_Mutation_p.E340K	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	358	Nudix box.|Nudix hydrolase.					nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		TTACCAGGCTCAATAAATCCA	0.318													23	71					0	0	0	0	T	102890447	T	T	102890447	3	4	145	1	0	0	0	0	1	0	0	0	10782	835	29	2	328	2	NUDT12	5	102890447	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	12783765	102890447	78024813	138	26558											
KCNN2	3781	broad.mit.edu	37	chr5	113831600	113831600	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgtttttcagacccagaaCatcatgtatgatatgatttc	11	15	6	9	0	2	4	2	2	0	2	3	4	2	4	2	0	1	2	2	0	3	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:113831600C>T	uc003kqo.2	+	8	1918	c.1461C>T	c.(1459-1461)AAC>AAT	p.N487N	KCNN2_uc003kqp.2_Silent_p.N139N|KCNN2_uc010jcg.2_RNA|uc003kqr.1_Intron	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	487	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		AGACCCAGAACATCATGTATG	0.408													40	125					0	0	0	0	T	113831600	T	T	113831600	2	4	145	1	0	0	0	0	0	0	0	1	8118	477	17	4		4	KCNN2	5	113831600	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	10941153	113831600	67083660	139	26559											
DMXL1	1657	broad.mit.edu	37	chr5	118576160	118576160	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcacctgccaatagtttaGtccatggtaagttttcaaag	12	13	8	8	0	1	0	1	0	0	0	2	0	2	0	3	1	2	4	3	1	6	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:118576160G>C	uc003ksd.2	+	41	8816	c.8635G>C	c.(8635-8637)GTC>CTC	p.V2879L	DMXL1_uc010jcl.1_Missense_Mutation_p.V2900L|DMXL1_uc010jcm.1_RNA|DMXL1_uc003kse.1_Missense_Mutation_p.V53L	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2879										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CAATAGTTTAGTCCATGGTAA	0.289													42	102					0	0	0	0	C	118576160	C	C	118576160	3	2	145	1	0	0	0	0	1	0	0	0	4616	1029	36	4	8797	4	DMXL1	5	118576160	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4744560	118576160	62339100	140	26560											
PCDHA11	56138	broad.mit.edu	37	chr5	140250129	140250129	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacagtgtcggcgcgggacGcggacgcgcaggagaacgcg	8	3	18	12	9	1	1	1	0	0	1	2	4	1	3	0	4	1	1	0	4	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:140250129G>C	uc003lia.2	+	1	2299	c.1441G>C	c.(1441-1443)GCG>CCG	p.A481P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.A481P	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	481	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGCGGGACGCGGACGCGCA	0.667													8	225					0	0	0	0	C	140250129	C	C	140250129	3	2	145	1	0	0	0	0	1	0	0	0	11575	1087	38	3	1443	3	PCDHA11	5	140250129	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	21673969	140250129	40665131	141	26561											
PCDHAC2	56134	broad.mit.edu	37	chr5	140347910	140347910	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcaagggctgccagtcacctCctatgtctccattaacagtg	9	11	8	13	0	3	0	2	0	1	0	5	0	4	0	4	1	2	1	4	1	3	2	rs148804197		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:140347910C>T	uc003lii.2	+	1	1799	c.1559C>T	c.(1558-1560)TCC>TTC	p.S520F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.S520F	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	520	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGTCACCTCCTATGTCTCC	0.507													6	102					0	0	0	0	T	140347910	T	T	140347910	3	4	145	1	0	0	0	0	1	0	0	0	11587	855	30	2	1561	2	PCDHAC2	5	140347910	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	97781	140347910	40567350	142	26562											
PCDHB11	56125	broad.mit.edu	37	chr5	140581330	140581330	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	accgccacgctgcaagtgctCctggtggacggcttctccca	6	8	11	16	3	1	0	0	0	1	0	3	1	2	1	4	3	2	4	4	3	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:140581330C>G	uc003liy.2	+	1	1983	c.1983C>G	c.(1981-1983)CTC>CTG	p.L661L	PCDHB11_uc011daj.1_Silent_p.L296L	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	661	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCAAGTGCTCCTGGTGGACG	0.706													9	162					0	0	0	0	G	140581330	G	G	140581330	2	3	145	1	0	0	0	0	0	0	0	1	11590	842	30	2		2	PCDHB11	5	140581330	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	233420	140581330	40333930	143	26563											
PCDHGA2	56113	broad.mit.edu	37	chr5	140719457	140719457	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactgacaatcataaaagatCtagattatgaggatgctaca	18	10	7	6	0	2	4	1	2	1	2	2	5	2	5	0	1	3	1	0	1	7	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:140719457C>T	uc003ljk.1	+	1	1104	c.919C>T	c.(919-921)CTA>TTA	p.L307L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.L307L	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	307	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATAAAAGATCTAGATTATGA	0.423													12	255					0	0	0	0	T	140719457	T	T	140719457	2	4	145	1	0	0	0	0	0	0	0	1	11608	912	32	2		2	PCDHGA2	5	140719457	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	138127	140719457	40195803	144	26564											
PCDHGA10	56106	broad.mit.edu	37	chr5	140795002	140795002	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacggggttcgggctttcCtgcagacctattcccacgag	6	10	13	12	3	0	1	0	0	0	1	3	3	2	2	3	4	1	3	3	4	1	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:140795002C>T	uc003lkl.1	+	1	2260	c.2260C>T	c.(2260-2262)CTG>TTG	p.L754L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.L754L|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	754	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGGCTTTCCTGCAGACCTA	0.627													83	122					0	0	0	0	T	140795002	T	T	140795002	2	4	145	1	0	0	0	0	0	0	0	1	11605	680	24	4		4	PCDHGA10	5	140795002	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	75545	140795002	40120258	145	26565											
SH3RF2	153769	broad.mit.edu	37	chr5	145439601	145439601	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggggtccaagcctgccctCacgggggagcccgccctcac	6	5	13	17	2	2	0	2	0	0	0	3	1	3	1	5	4	3	0	5	4	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:145439601C>T	uc003lnt.2	+	9	1966	c.1728C>T	c.(1726-1728)CTC>CTT	p.L576L	SH3RF2_uc011dbl.1_Silent_p.L576L|SH3RF2_uc011dbm.1_Silent_p.L61L|SH3RF2_uc003lnu.2_Silent_p.L67L|SH3RF2_uc011dbn.1_Silent_p.L67L|SH3RF2_uc011dbo.1_Silent_p.L33L	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	576							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCTGCCCTCACGGGGGAGC	0.632													38	74					0	0	0	0	T	145439601	T	T	145439601	2	4	145	1	0	0	0	0	0	0	0	1	14324	813	29	2		2	SH3RF2	5	145439601	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	4644599	145439601	35475659	146	26566											
GABRA1	2554	broad.mit.edu	37	chr5	161324208	161324208	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taatttggccaggggcgaccCgggcttagccaccattgcta	8	9	12	12	2	0	0	0	0	0	0	0	1	0	0	4	4	2	2	4	4	3	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:161324208C>A	uc010jiw.2	+	11	1619	c.1151C>A	c.(1150-1152)CCG>CAG	p.P384Q	GABRA1_uc010jix.2_Missense_Mutation_p.P384Q|GABRA1_uc010jiy.2_Missense_Mutation_p.P384Q|GABRA1_uc003lyx.3_Missense_Mutation_p.P384Q|GABRA1_uc010jiz.2_Missense_Mutation_p.P384Q|GABRA1_uc010jja.2_Missense_Mutation_p.P384Q|GABRA1_uc010jjb.2_Missense_Mutation_p.P384Q	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	384	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	AGGGGCGACCCGGGCTTAGCC	0.458													85	113					2.02726e-29	3.61074e-29	1	0	A	161324208	A	A	161324208	3	1	145	1	0	0	0	0	1	0	0	0	6194	652	23	3	1185	3	GABRA1	5	161324208	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	15884607	161324208	19591052	147	26567											
ZFP2	80108	broad.mit.edu	37	chr5	178358636	178358636	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctatgaatgtaatcagtgcAgcaaaaccttcagtcagagc	14	10	8	9	0	4	2	3	1	1	1	4	2	4	2	1	0	4	3	1	0	5	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:178358636A>T	uc003mjn.1	+	5	831	c.322A>T	c.(322-324)AGC>TGC	p.S108C	ZFP2_uc010jky.2_Missense_Mutation_p.S108C|ZFP2_uc010jkx.1_Missense_Mutation_p.S108C	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	108	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		TAATCAGTGCAGCAAAACCTT	0.373													23	33					0	0	0	0	T	178358636	T	T	178358636	3	4	145	1	0	0	0	0	1	0	0	0	17708	188	7	5	324	5	ZFP2	5	178358636	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	17034428	178358636	2556624	148	26568											
ZNF354C	30832	broad.mit.edu	37	chr5	178506641	178506641	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaacccttatcgaacatcAgcgaattcacactggacaaa	15	9	6	11	2	2	0	2	0	0	0	3	3	2	1	1	1	3	1	1	1	5	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:178506641A>G	uc003mju.2	+	5	1323	c.1208A>G	c.(1207-1209)CAG>CGG	p.Q403R		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	403	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		ATCGAACATCAGCGAATTCAC	0.408													3	158					0	0	0	0	G	178506641	G	G	178506641	3	3	145	1	0	0	0	0	1	0	0	0	17933	188	7	5	1222	5	ZNF354C	5	178506641	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	148005	178506641	2408619	149	26569											
HIST1H3D	8351	broad.mit.edu	37	chr6	26197326	26197326	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttctggtagcggcggatCtcgcgcagagccaccgtgcc	6	7	14	14	5	2	1	0	0	2	1	3	3	2	2	3	3	3	2	3	3	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:26197326C>T	uc003ngv.2	-	2	550	c.153G>A	c.(151-153)GAG>GAA	p.E51E	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	51					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				AGCGGCGGATCTCGCGCAGAG	0.632													49	107					0	0	0	0	T	26197326	T	T	26197326	2	4	145	1	0	0	0	0	0	0	0	1	7197	912	32	2		2	HIST1H3D	6	26197326	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08		26197326	144917741	150	26570											
BTN3A2	11118	broad.mit.edu	37	chr6	26370714	26370714	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgtggttgcagatggagtgGgcctatatgaagtagcagca	10	10	15	6	0	0	2	0	1	0	1	0	3	0	3	1	3	3	5	1	3	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:26370714G>T	uc010jqh.1	+	5	857	c.598G>T	c.(598-600)GGC>TGC	p.G200C	BTN3A2_uc003nho.1_Missense_Mutation_p.G198C|BTN3A2_uc003nhp.2_Missense_Mutation_p.G200C|BTN3A2_uc011dkd.1_Missense_Mutation_p.G158C|BTN3A2_uc011dke.1_Missense_Mutation_p.G177C|BTN3A2_uc010jqi.1_Missense_Mutation_p.G198C	NM_007047	NP_008978	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2 precursor	200	Extracellular (Potential).					integral to membrane					0						AGATGGAGTGGGCCTATATGA	0.567													67	196					2.17656e-39	3.99593e-39	1	0	T	26370714	T	T	26370714	3	4	145	1	0	0	0	0	1	0	0	0	1568	1232	43	4	608	4	BTN3A2	6	26370714	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	173388	26370714	144744353	151	26571											
SCAND3	114821	broad.mit.edu	37	chr6	28541503	28541503	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttggttttcccttcttcAggataacttctattgttaac	7	20	5	9	0	3	0	1	0	2	0	4	1	4	1	1	2	2	2	1	2	3	11			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:28541503A>C	uc003nlo.2	-	4	2781	c.2163T>G	c.(2161-2163)CCT>CCG	p.P721P		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	721					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						tcccttcttcaggataacttc	0													4	34					0	0	0	0	C	28541503	C	C	28541503	2	2	145	1	0	0	0	0	0	0	0	1	13941	175	7	5		5	SCAND3	6	28541503	Silent	SNP	A	TCGA-CR-7374-01A-11D-2012-08	2170789	28541503	142573564	152	26572											
RNF39	80352	broad.mit.edu	37	chr6	30043359	30043359	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgggcccagctcgggcgcatCcatggaaagccaggatctgg	8	5	15	13	3	1	0	0	0	1	0	3	2	2	2	3	5	2	2	3	5	1	0	rs141667762		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:30043359C>G	uc003npe.2	-	1	270	c.208G>C	c.(208-210)GAT>CAT	p.D70H	RNF39_uc003npd.2_Missense_Mutation_p.D70H	NM_025236	NP_079512	Q9H2S5	RNF39_HUMAN	ring finger protein 39 isoform 1	70						cytoplasm	zinc ion binding				0						TCGGGCGCATCCATGGAAAGC	0.701													19	33					0	0	0	0	G	30043359	G	G	30043359	3	3	145	1	0	0	0	0	1	0	0	0	13556	855	30	2	1070	2	RNF39	6	30043359	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1501856	30043359	141071708	153	26573											
AGER	177	broad.mit.edu	37	chr6	32148952	32148952	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtactactctcgcctgcctCaggttcctccgactgattca	7	12	7	15	2	3	1	2	1	1	0	6	2	5	1	4	1	3	2	4	1	2	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:32148952C>T	uc003oal.1	-	11	1207	c.1183G>A	c.(1183-1185)GAG>AAG	p.E395K	AGER_uc003oak.1_Missense_Mutation_p.E124K|AGER_uc003oar.2_Missense_Mutation_p.E294K|AGER_uc011dpm.1_Missense_Mutation_p.E285K|AGER_uc011dpn.1_3'UTR|AGER_uc010jtv.1_3'UTR|AGER_uc011dpo.1_3'UTR|AGER_uc003oam.1_RNA|AGER_uc003oan.1_Silent_p.*343*|AGER_uc003oap.1_Missense_Mutation_p.E411K|AGER_uc003oat.1_3'UTR|AGER_uc003oao.1_RNA|AGER_uc003oaq.1_Missense_Mutation_p.E381K|AGER_uc010jtw.1_RNA|AGER_uc003oas.1_3'UTR|AGER_uc003oau.1_3'UTR	NM_001136	NP_001127	Q15109	RAGE_HUMAN	advanced glycosylation end product-specific	395	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response|neuron projection development|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	S100 alpha binding|transmembrane receptor activity			breast(1)	1						TCGCCTGCCTCAGGTTCCTCC	0.557													7	438					0	0	0	0	T	32148952	T	T	32148952	3	4	145	1	0	0	0	0	1	0	0	0	379	838	29	2	35	2	AGER	6	32148952	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2105593	32148952	138966115	154	26574											
TAP2	6891	broad.mit.edu	37	chr6	32797792	32797792	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcaccttatcatcttcgcaGctctgcagcccataagcaat	11	11	5	14	1	4	0	2	0	2	0	5	0	4	0	2	0	4	4	2	0	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:32797792G>C	uc003occ.2	-	9	1741	c.1710C>G	c.(1708-1710)AGC>AGG	p.S570R	TAP2_uc011dqf.1_Missense_Mutation_p.S570R|TAP2_uc003ocb.1_Missense_Mutation_p.S570R|TAP2_uc003ocd.2_Missense_Mutation_p.S570R	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	570	ABC transporter.|Cytoplasmic (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						CATCTTCGCAGCTCTGCAGCC	0.537													61	142					0	0	0	0	C	32797792	C	C	32797792	3	2	145	1	0	0	0	0	1	0	0	0	15617	962	34	4	447	4	TAP2	6	32797792	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	648840	32797792	138317275	155	26575											
ZBTB22	9278	broad.mit.edu	37	chr6	33283712	33283712	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcctcacaggtcaacaccaGatcttcctcctcctcttcct	8	12	3	18	0	4	1	2	0	2	1	9	1	9	1	6	1	1	0	6	1	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:33283712G>C	uc003oeb.2	-	2	1134	c.982C>G	c.(982-984)CTG>GTG	p.L328V	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.L328V	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTCAACACCAGATCTTCCTCC	0.557													16	166					0	0	0	0	C	33283712	C	C	33283712	3	2	145	1	0	0	0	0	1	0	0	0	17597	933	33	2	926	2	ZBTB22	6	33283712	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	485920	33283712	137831355	156	26576											
DAXX	1616	broad.mit.edu	37	chr6	33287564	33287564	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagatctgctgatctgtttGccaggttccaggttcttttc	6	16	10	9	0	3	2	0	1	3	1	5	3	4	2	2	2	2	4	2	2	1	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:33287564G>C	uc003oec.2	-	6	1737	c.1533C>G	c.(1531-1533)GGC>GGG	p.G511G	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Silent_p.G436G|DAXX_uc011dre.1_Silent_p.G523G|DAXX_uc003oed.2_Silent_p.G511G	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	511	Asp/Glu-rich (acidic).|Interaction with MAP3K5.|Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						TGATCTGTTTGCCAGGTTCCA	0.502			Mis|F|N		Pancreatic neuroendocrine tumors								9	118					0	0	0	0	C	33287564	C	C	33287564	2	2	145	1	0	0	0	0	0	0	0	1	4260	1306	46	4		4	DAXX	6	33287564	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3852	33287564	137827503	157	26577											
PPARD	5467	broad.mit.edu	37	chr6	35378951	35378951	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagaaggagccccagagctCaatgggggaccacagcatgc	12	3	14	12	0	1	2	1	0	0	2	1	4	1	4	3	3	4	3	3	3	2	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:35378951C>G	uc003okm.2	+	3	396	c.87C>G	c.(85-87)CTC>CTG	p.L29L	PPARD_uc003okl.2_Silent_p.L29L|PPARD_uc003okn.2_Silent_p.L29L|PPARD_uc011dtb.1_Intron|PPARD_uc011dtc.1_Silent_p.L29L|PPARD_uc010jvv.1_RNA	NM_006238	NP_006229	Q03181	PPARD_HUMAN	peroxisome proliferative activated receptor,	29					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	CCCCAGAGCTCAATGGGGGAC	0.627													16	68					0	0	0	0	G	35378951	G	G	35378951	2	3	145	1	0	0	0	0	0	0	0	1	12353	813	29	2		2	PPARD	6	35378951	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2091387	35378951	135736116	158	26578											
MAPK13	5603	broad.mit.edu	37	chr6	36106682	36106682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acctgctggagaagatgctgGagctagacgtggacaagcgc	11	6	15	9	2	0	3	0	0	0	3	0	6	0	5	1	3	4	3	1	3	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:36106682G>A	uc003ols.2	+	11	966	c.868G>A	c.(868-870)GAG>AAG	p.E290K	MAPK13_uc003olt.2_RNA	NM_002754	NP_002745	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	290	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3						GAAGATGCTGGAGCTAGACGT	0.672													22	81					0	0	0	0	A	36106682	A	A	36106682	3	1	145	1	0	0	0	0	1	0	0	0	9328	1175	41	2	910	2	MAPK13	6	36106682	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	727731	36106682	135008385	159	26579											
DNAH8	1769	broad.mit.edu	37	chr6	38759381	38759381	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagttctgaaggagatagcCaaaactgtgttgatttctct	12	13	9	7	0	2	3	0	2	2	1	3	4	2	3	1	1	2	2	1	1	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:38759381C>T	uc003ooe.1	+	19	2781	c.2181C>T	c.(2179-2181)GCC>GCT	p.A727A		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGGAGATAGCCAAAACTGTGT	0.353													20	37					0	0	0	0	T	38759381	T	T	38759381	2	4	145	1	0	0	0	0	0	0	0	1	4629	581	21	4		4	DNAH8	6	38759381	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2652699	38759381	132355686	160	26580											
TREM1	54210	broad.mit.edu	37	chr6	41250265	41250265	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacgcgcagtaaaccatgatCatggtagtcttctagtatga	12	11	10	8	2	3	2	1	2	2	0	3	3	3	2	1	1	1	4	1	1	5	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:41250265C>G	uc003oqf.1	-	2	338	c.274G>C	c.(274-276)GAT>CAT	p.D92H	TREM1_uc003oqg.1_Missense_Mutation_p.D92H	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	92	Extracellular (Potential).|Ig-like V-type.				blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	AAACCATGATCATGGTAGTCT	0.512													24	94					0	0	0	0	G	41250265	G	G	41250265	3	3	145	1	0	0	0	0	1	0	0	0	16537	826	29	2	442	2	TREM1	6	41250265	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2490884	41250265	129864802	161	26581											
SLC35B2	347734	broad.mit.edu	37	chr6	44224086	44224086	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccacctacccacctggagcCctgtggcacagaagagcagc	10	4	10	17	0	0	2	0	0	0	2	0	3	0	3	5	2	4	2	5	2	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:44224086C>T	uc003oxd.2	-	3	489	c.353G>A	c.(352-354)GGG>GAG	p.G118E	SLC35B2_uc011dvt.1_Intron|SLC35B2_uc011dvu.1_Intron	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	118	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CACCTGGAGCCCTGTGGCACA	0.622													86	199					0	0	0	0	T	44224086	T	T	44224086	3	4	145	1	0	0	0	0	1	0	0	0	14640	623	22	4	953	4	SLC35B2	6	44224086	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2973821	44224086	126890981	162	26582											
GPR116	221395	broad.mit.edu	37	chr6	46830642	46830642	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccttagccatctggagcaGactgtttattggggcagaga	10	10	12	9	0	1	2	0	0	1	2	1	4	1	3	2	3	2	3	2	3	2	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:46830642G>C	uc003oyo.3	-	15	2471	c.2182C>G	c.(2182-2184)CTG>GTG	p.L728V	GPR116_uc011dwj.1_Missense_Mutation_p.L283V|GPR116_uc011dwk.1_Missense_Mutation_p.L157V|GPR116_uc003oyp.3_Missense_Mutation_p.L586V|GPR116_uc003oyq.3_Missense_Mutation_p.L728V|GPR116_uc010jzi.1_Missense_Mutation_p.L400V	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	728	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			ATCTGGAGCAGACTGTTTATT	0.502													73	281					0	0	0	0	C	46830642	C	C	46830642	3	2	145	1	0	0	0	0	1	0	0	0	6671	933	33	2	1886	2	GPR116	6	46830642	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2606556	46830642	124284425	163	26583											
TNFRSF21	27242	broad.mit.edu	37	chr6	47200672	47200672	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtggagcatgtcatcaaaGataggctgcaagtcacaggg	14	7	13	7	0	3	1	3	0	0	1	3	2	3	2	0	3	2	3	0	3	4	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:47200672G>C	uc003oyv.2	-	6	2230	c.1797C>G	c.(1795-1797)ATC>ATG	p.I599M		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	599	Cytoplasmic (Potential).				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			TGTCATCAAAGATAGGCTGCA	0.498													13	239					0	0	0	0	C	47200672	C	C	47200672	3	2	145	1	0	0	0	0	1	0	0	0	16361	932	33	2	174	2	TNFRSF21	6	47200672	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	370030	47200672	123914395	164	26584											
GCM1	8521	broad.mit.edu	37	chr6	52993279	52993279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acagccagttttggctgcagGtggctccaatggaagctgct	8	10	13	10	0	0	0	0	0	0	0	1	1	1	1	2	4	4	6	2	4	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:52993279G>A	uc003pbp.2	-	6	1245	c.1036C>T	c.(1036-1038)CCT>TCT	p.P346S		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	346						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					TTGGCTGCAGGTGGCTCCAAT	0.473													39	162					0	0	0	0	A	52993279	A	A	52993279	3	1	145	1	0	0	0	0	1	0	0	0	6332	1261	44	4	278	4	GCM1	6	52993279	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	5792607	52993279	118121788	165	26585											
BAI3	577	broad.mit.edu	37	chr6	70071204	70071204	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tattgcactacaaagtaaacCctgaattcaatatgaatccc	16	11	4	10	0	1	2	1	2	0	0	2	2	2	2	2	0	3	2	2	0	9	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:70071204C>A	uc003pev.3	+	29	4487	c.4039C>A	c.(4039-4041)CCT>ACT	p.P1347T	BAI3_uc010kak.2_Missense_Mutation_p.P1347T|BAI3_uc011dxx.1_Missense_Mutation_p.P553T	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1347	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CAAAGTAAACCCTGAATTCAA	0.403													77	122					7.97268e-31	1.42355e-30	1	0	A	70071204	A	A	70071204	3	1	145	1	0	0	0	0	1	0	0	0	1302	623	22	4	4145	4	BAI3	6	70071204	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	17077925	70071204	101043863	166	26586											
FAM135A	57579	broad.mit.edu	37	chr6	71185189	71185189	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcaaattttgtacaaaaaTgaagaggttgttttaaatga	16	16	7	2	0	1	3	1	2	0	1	1	3	1	3	0	1	1	3	0	1	7	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:71185189T>C	uc003pfj.2	+	4	367	c.234T>C	c.(232-234)AAT>AAC	p.N78N	FAM135A_uc003pfi.2_Silent_p.N78N|FAM135A_uc003pfh.2_Silent_p.N35N|FAM135A_uc003pfk.2_Silent_p.N78N|FAM135A_uc003pfl.2_5'UTR	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	78										central_nervous_system(1)	1						TGTACAAAAATGAAGAGGTTG	0.264													5	43					0	0	0	0	C	71185189	C	C	71185189	2	2	145	1	0	0	0	0	0	0	0	1	5476	1461	51	5		5	FAM135A	6	71185189	Silent	SNP	T	TCGA-CR-7374-01A-11D-2012-08	1113985	71185189	99929878	167	26587											
ANKRD6	22881	broad.mit.edu	37	chr6	90331648	90331648	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgcctccttcaggtcttgcGcttcagtcgtgggcgaagcc	4	12	12	13	3	3	0	2	0	1	0	5	1	4	0	3	2	3	1	3	2	1	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:90331648G>T	uc003pni.3	+	10	1141	c.800G>T	c.(799-801)CGC>CTC	p.R267L	ANKRD6_uc003pne.3_Missense_Mutation_p.R267L|ANKRD6_uc003pnf.3_Intron|ANKRD6_uc011dzy.1_Missense_Mutation_p.R267L|ANKRD6_uc010kcd.2_Missense_Mutation_p.R208L|LYRM2_uc010kce.1_RNA|LYRM2_uc003png.2_RNA|ANKRD6_uc003pnh.3_5'UTR|LYRM2_uc010kcf.1_RNA|ANKRD6_uc003pnj.3_5'UTR	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	267	ANK 8.						protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		CAGGTCTTGCGCTTCAGTCGT	0.547													22	64					7.45023e-12	1.18017e-11	1	0	T	90331648	T	T	90331648	3	4	145	1	0	0	0	0	1	0	0	0	685	1087	38	3	834	3	ANKRD6	6	90331648	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	19146459	90331648	80783419	168	26588											
C6orf170	221322	broad.mit.edu	37	chr6	121482138	121482138	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatccgttccaatggcccacCaacaagatttattctaacaa	15	10	4	12	1	1	1	0	0	1	1	3	1	3	1	4	1	2	1	4	1	7	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:121482138C>A	uc003pyo.1	-	23	2703	c.2635G>T	c.(2635-2637)GGT>TGT	p.G879C	C6orf170_uc003pyq.1_RNA|C6orf170_uc010kej.1_5'UTR|C6orf170_uc003pyp.1_Missense_Mutation_p.G439C	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	879					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		AATGGCCCACCAACAAGATTT	0.383													30	82					5.90632e-09	9.09447e-09	1	0	A	121482138	A	A	121482138	3	1	145	1	0	0	0	0	1	0	0	0	2354	594	21	4	1178	4	C6orf170	6	121482138	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	31150490	121482138	49632929	169	26589											
MAP3K5	4217	broad.mit.edu	37	chr6	136990454	136990454	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaaaggaagattcaaactGgtgtccagctgccaggagga	13	7	12	9	0	2	1	2	0	0	1	3	4	3	4	2	4	3	1	2	4	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:136990454G>A	uc003qhc.2	-	8	1694	c.1333C>T	c.(1333-1335)CAG>TAG	p.Q445*	MAP3K5_uc011edk.1_Nonsense_Mutation_p.Q290*|MAP3K5_uc010kgw.1_Nonsense_Mutation_p.Q445*	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	445					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GATTCAAACTGGTGTCCAGCT	0.393													52	143					0	0	0	0	A	136990454	A	A	136990454	4	1	145	1	0	0	0	0	0	1	0	0	9306	1357	47	4	2883	4	MAP3K5	6	136990454	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	15508316	136990454	34124613	170	26590											
STXBP5	134957	broad.mit.edu	37	chr6	147684646	147684646	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtatccccctcctcttctcaGgaaattagtgaaaaccagta	12	11	6	12	0	2	1	1	1	2	0	5	2	4	2	4	1	1	2	4	1	6	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:147684646G>A	uc003qlz.2	+	24	2882	c.2721G>A	c.(2719-2721)CAG>CAA	p.Q907Q	STXBP5_uc010khz.1_Silent_p.Q871Q|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Silent_p.Q562Q	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	907	WD 12.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		CCTCTTCTCAGGAAATTAGTG	0.418													16	54					0	0	0	0	A	147684646	A	A	147684646	2	1	145	1	0	0	0	0	0	0	0	1	15422	991	35	4		4	STXBP5	6	147684646	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	10694192	147684646	23430421	171	26591											
MICALL2	79778	broad.mit.edu	37	chr7	1481953	1481953	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgcctgccgggggcaacgcgGatgcctgagaggtactgctc	6	7	16	12	3	0	1	0	1	0	1	1	3	0	2	3	4	6	3	3	4	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:1481953G>T	uc003skj.3	-	7	1733	c.1586C>A	c.(1585-1587)TCC>TAC	p.S529Y	MICALL2_uc003ski.3_Missense_Mutation_p.S16Y	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	529						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GGGCAACGCGGATGCCTGAGA	0.667													20	236					7.45023e-12	1.18017e-11	1	0	T	1481953	T	T	1481953	3	4	145	1	0	0	0	0	1	0	0	0	9627	1174	41	2	1172	2	MICALL2	7	1481953	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08		1481953	157656710	172	26592											
FOXK1	221937	broad.mit.edu	37	chr7	4722314	4722314	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgccagcccagcgtcaccatCggccgcaactcgtcgcaggg	7	4	12	18	6	1	0	1	0	0	0	4	0	1	0	4	2	3	2	4	2	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:4722314C>G	uc003snc.1	+	1	385	c.375C>G	c.(373-375)ATC>ATG	p.I125M	FOXK1_uc003sna.1_Intron|FOXK1_uc003snb.1_Missense_Mutation_p.I125M	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	125	FHA.				cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		GCGTCACCATCGGCCGCAACT	0.647													5	38					0	0	0	0	G	4722314	G	G	4722314	3	3	145	1	0	0	0	0	1	0	0	0	6048	874	31	3	377	3	FOXK1	7	4722314	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	3240361	4722314	154416349	173	26593											
FOXK1	221937	broad.mit.edu	37	chr7	4800781	4800781	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggccagccagatggcccccGgggtccccggacacacggtc	6	4	14	17	3	0	1	0	0	0	1	2	2	1	2	6	6	1	0	6	6	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:4800781G>A	uc003snc.1	+	8	1793	c.1783G>A	c.(1783-1785)GGG>AGG	p.G595R	FOXK1_uc003sna.1_Missense_Mutation_p.G432R	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	595					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		GATGGCCCCCGGGGTCCCCGG	0.672													42	93					0	0	0	0	A	4800781	A	A	4800781	3	1	145	1	0	0	0	0	1	0	0	0	6048	1116	39	1	1813	1	FOXK1	7	4800781	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	78467	4800781	154337882	174	26594											
TNRC18	84629	broad.mit.edu	37	chr7	5353145	5353145	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtccagtttgacaagcagCtcggcctcctcccccggcct	5	9	10	17	2	0	1	0	1	0	0	4	1	3	1	6	3	2	3	6	3	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:5353145C>T	uc003soi.3	-	27	7726	c.7377G>A	c.(7375-7377)GAG>GAA	p.E2459E		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2459							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		TGACAAGCAGCTCGGCCTCCT	0.687													21	38					0	0	0	0	T	5353145	T	T	5353145	2	4	145	1	0	0	0	0	0	0	0	1	16405	796	28	4		4	TNRC18	7	5353145	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	552364	5353145	153785518	175	26595											
DNAH11	8701	broad.mit.edu	37	chr7	21640667	21640667	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtatgttcaaatgagcaaaTttgaggactttagagtgttt	12	16	10	3	0	1	3	1	2	0	1	1	4	1	4	0	1	1	4	0	1	4	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:21640667T>C	uc003svc.2	+	17	3326	c.3295T>C	c.(3295-3297)TTT>CTT	p.F1099L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1099	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AATGAGCAAATTTGAGGACTT	0.333									Kartagener_syndrome				22	74					0	0	0	0	C	21640667	C	C	21640667	3	2	145	1	0	0	0	0	1	0	0	0	4621	1493	52	5	3361	5	DNAH11	7	21640667	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	16287522	21640667	137497996	176	26596											
C7orf30	115416	broad.mit.edu	37	chr7	23348989	23348989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacaggcagcatggtgattCatttgatgcttccagaaacc	11	11	10	9	0	1	4	1	3	0	1	2	4	2	4	2	2	3	3	2	2	1	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:23348989C>T	uc003swd.1	+	4	564	c.532C>T	c.(532-534)CAT>TAT	p.H178Y	C7orf30_uc003swe.2_RNA	NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	178						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			CATGGTGATTCATTTGATGCT	0.398													39	127					0	0	0	0	T	23348989	T	T	23348989	3	4	145	1	0	0	0	0	1	0	0	0	2397	826	29	2	546	2	C7orf30	7	23348989	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1708322	23348989	135789674	177	26597											
HERPUD2	64224	broad.mit.edu	37	chr7	35673933	35673933	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcacataccatttcttcaaGttccaagttgtttgcatttt	10	18	4	9	0	3	0	2	0	1	0	4	0	4	0	2	0	2	4	2	0	3	8			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:35673933G>C	uc003tet.2	-	7	1853	c.1048C>G	c.(1048-1050)CTT>GTT	p.L350V	HERPUD2_uc003tes.3_Missense_Mutation_p.L350V	NM_022373	NP_071768	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	350					response to unfolded protein	integral to membrane				ovary(3)	3						ATTTCTTCAAGTTCCAAGTTG	0.408													35	66					0	0	0	0	C	35673933	C	C	35673933	3	2	145	1	0	0	0	0	1	0	0	0	7103	1029	36	4	180	4	HERPUD2	7	35673933	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	12324944	35673933	123464730	178	26598											
DBNL	28988	broad.mit.edu	37	chr7	44091508	44091508	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcagagtgaaggaccccaaCtctggactgcccaaatttgt	11	9	10	11	0	1	2	0	1	1	1	1	4	1	4	3	2	3	1	3	2	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:44091508C>T	uc003tjp.3	+	3	317	c.219C>T	c.(217-219)AAC>AAT	p.N73N	DBNL_uc003tjn.2_Intron|DBNL_uc003tjo.3_Silent_p.N73N|DBNL_uc003tjr.3_Intron|DBNL_uc003tjq.3_Silent_p.N73N|DBNL_uc011kbm.1_Silent_p.N73N|DBNL_uc011kbn.1_Intron|DBNL_uc011kbo.1_Intron|DBNL_uc011kbp.1_Silent_p.N73N|DBNL_uc011kbq.1_Intron|DBNL_uc011kbr.1_Silent_p.N21N|DBNL_uc011kbs.1_5'Flank	NM_001014436	NP_001014436	Q9UJU6	DBNL_HUMAN	drebrin-like isoform b	73	ADF-H.				activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			skin(1)	1						AGGACCCCAACTCTGGACTGC	0.527													33	97					0	0	0	0	T	44091508	T	T	44091508	2	4	145	1	0	0	0	0	0	0	0	1	4272	564	20	4		4	DBNL	7	44091508	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	8417575	44091508	115047155	179	26599											
SUMF2	25870	broad.mit.edu	37	chr7	56147375	56147375	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctggccatgttgcaaacagCgcaattccaagctcgagagc	11	7	10	13	2	0	1	0	0	0	1	2	2	1	1	3	1	5	4	3	1	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:56147375C>T	uc003trv.2	+	8	919	c.888C>T	c.(886-888)AGC>AGT	p.S296S	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_3'UTR|SUMF2_uc011kcx.1_3'UTR|SUMF2_uc003trt.2_3'UTR|SUMF2_uc011kcy.1_3'UTR|SUMF2_uc011kcz.1_3'UTR|SUMF2_uc003tru.2_RNA|SUMF2_uc011kda.1_Silent_p.S109S|SUMF2_uc003trx.2_RNA	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	Error:Variant_position_missing_in_Q8NBJ7_after_alignment						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTGCAAACAGCGCAATTCCAA	0.602											OREG0018082	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	52					0	0	0	0	T	56147375	T	T	56147375	2	4	145	1	0	0	0	0	0	0	0	1	15452	767	27	1		1	SUMF2	7	56147375	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	12055867	56147375	102991288	180	26600											
RABGEF1	27342	broad.mit.edu	37	chr7	66236935	66236935	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatgtggatcaatcggatCtcctgtgcaagaaaggatgt	11	12	11	7	1	3	1	2	0	1	1	5	4	3	4	1	3	1	1	1	3	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:66236935C>G	uc011kee.1	+	2	255	c.91C>G	c.(91-93)CTC>GTC	p.L31V	RABGEF1_uc003tvf.2_Translation_Start_Site|RABGEF1_uc003tvg.2_Translation_Start_Site|RABGEF1_uc010lag.2_Missense_Mutation_p.L17V|RABGEF1_uc003tvh.2_Missense_Mutation_p.L17V|RABGEF1_uc003tvi.2_Translation_Start_Site	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	155	Interaction with ubiquitinated proteins.|A20-type.				endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						TCAATCGGATCTCCTGTGCAA	0.483													50	231					0	0	0	0	G	66236935	G	G	66236935	3	3	145	1	0	0	0	0	1	0	0	0	13031	913	32	2	51	2	RABGEF1	7	66236935	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	10089560	66236935	92901728	181	26601											
TYW1	55253	broad.mit.edu	37	chr7	66479523	66479523	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtatttggcctgggaaattCtgcctatgctagccacttca	8	13	10	10	0	2	0	1	0	1	0	2	1	2	1	3	3	3	2	3	3	4	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:66479523C>T	uc003tvn.2	+	5	694	c.545C>T	c.(544-546)TCT>TTT	p.S182F	TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	182	FMN (By similarity).|Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				CTGGGAAATTCTGCCTATGCT	0.333													63	293					0	0	0	0	T	66479523	T	T	66479523	3	4	145	1	0	0	0	0	1	0	0	0	16886	913	32	2	563	2	TYW1	7	66479523	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	242588	66479523	92659140	182	26602											
ABCB4	5244	broad.mit.edu	37	chr7	87056098	87056098	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccacatcaaggctcttctGacacatttgtgaatttttaa	11	16	5	9	0	3	2	1	2	2	0	4	2	4	2	1	1	0	1	1	1	3	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:87056098G>A	uc003uiv.1	-	16	2108	c.2032C>T	c.(2032-2034)CAG>TAG	p.Q678*	ABCB4_uc003uiw.1_Nonsense_Mutation_p.Q678*|ABCB4_uc003uix.1_Nonsense_Mutation_p.Q678*	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	678	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AGGCTCTTCTGACACATTTGT	0.353													27	39					0	0	0	0	A	87056098	A	A	87056098	4	1	145	1	0	0	0	0	0	1	0	0	43	1299	45	2	1880	2	ABCB4	7	87056098	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	20576575	87056098	72082565	183	26603											
COL1A2	1278	broad.mit.edu	37	chr7	94057155	94057155	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagaaagaacccagctcgcAcatgccgtgacttgagactc	12	7	9	13	2	0	4	0	2	0	3	2	5	0	4	2	0	3	2	2	0	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:94057155A>C	uc003ung.1	+	49	3955	c.3484A>C	c.(3484-3486)ACA>CCA	p.T1162P	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1162	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCCAGCTCGCACATGCCGTGA	0.488										HNSCC(75;0.22)			32	24					0	0	0	0	C	94057155	C	C	94057155	3	2	145	1	0	0	0	0	1	0	0	0	3693	159	6	5	3678	5	COL1A2	7	94057155	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	7001057	94057155	65081508	184	26604											
TRIP6	7205	broad.mit.edu	37	chr7	100466214	100466214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctatgggggccccactcCagcctcttacactaccgcca	7	8	7	19	1	1	0	0	0	1	0	3	0	3	0	7	2	3	0	7	2	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:100466214C>T	uc003uww.2	+	4	631	c.461C>T	c.(460-462)CCA>CTA	p.P154L	TRIP6_uc010lhk.1_RNA	NM_003302	NP_003293	Q15654	TRIP6_HUMAN	thyroid receptor-interacting protein 6	154					focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGCCCCACTCCAGCCTCTTAC	0.697													7	65					0	0	0	0	T	100466214	T	T	100466214	3	4	145	1	0	0	0	0	1	0	0	0	16626	594	21	4	475	4	TRIP6	7	100466214	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	6409059	100466214	58672449	185	26605											
MUC17	140453	broad.mit.edu	37	chr7	100677694	100677694	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgctggtggccaattctgaGgctagcaccctttcaacaac	10	9	9	13	1	2	1	1	1	1	0	2	1	2	1	2	3	3	3	2	3	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:100677694G>T	uc003uxp.1	+	3	3050	c.2997G>T	c.(2995-2997)GAG>GAT	p.E999D	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	999	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|14.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAATTCTGAGGCTAGCACCC	0.522													307	339					9.82643e-173	1.87619e-172	1	0	T	100677694	T	T	100677694	3	4	145	1	0	0	0	0	1	0	0	0	10027	991	35	4	3007	4	MUC17	7	100677694	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	211480	100677694	58460969	186	26606											
CUX1	1523	broad.mit.edu	37	chr7	101918582	101918582	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattcactgctttccatcatCtccagccagagggagcgctt	8	11	9	13	1	3	1	2	0	1	1	5	3	4	2	3	1	3	2	3	1	0	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:101918582C>G	uc003uyt.2	+	17	1534	c.1515C>G	c.(1513-1515)ATC>ATG	p.I505M	CUX1_uc011kkn.1_Missense_Mutation_p.I466M|CUX1_uc003uyw.2_Missense_Mutation_p.I459M|CUX1_uc003uyv.2_Missense_Mutation_p.I489M|CUX1_uc003uyu.2_Missense_Mutation_p.I503M|CUX1_uc003uyz.2_RNA	NM_001913	NP_001904	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform b	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						TTTCCATCATCTCCAGCCAGA	0.632													12	92					0	0	0	0	G	101918582	G	G	101918582	3	3	145	1	0	0	0	0	1	0	0	0	4081	903	32	2	4951	2	CUX1	7	101918582	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1240888	101918582	57220081	187	26607											
CPA4	51200	broad.mit.edu	37	chr7	129948163	129948163	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcagaaccgattatggaggaAgacgcggtcccgaaatcctg	12	7	12	10	4	1	2	1	0	0	2	3	6	3	4	3	3	1	0	3	3	4	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:129948163A>C	uc003vpr.2	+	8	766	c.719A>C	c.(718-720)AAG>ACG	p.K240T	CPA4_uc011kpd.1_Missense_Mutation_p.K207T|CPA4_uc011kpe.1_Missense_Mutation_p.K136T	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	240					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TTATGGAGGAAGACGCGGTCC	0.537													31	40					0	0	0	0	C	129948163	C	C	129948163	3	2	145	1	0	0	0	0	1	0	0	0	3807	72	3	5	749	5	CPA4	7	129948163	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	28029581	129948163	29190500	188	26608											
OR2A25	392138	broad.mit.edu	37	chr7	143772094	143772094	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catcatcatgtatgttgagcCccagtatgagagccccaagg	11	9	10	11	0	2	2	2	2	0	1	2	3	2	2	4	1	2	3	4	1	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:143772094C>A	uc011ktx.1	+	1	782	c.782C>A	c.(781-783)CCC>CAC	p.P261H		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TATGTTGAGCCCCAGTATGAG	0.488													135	168					2.4537e-52	4.58707e-52	1	0	A	143772094	A	A	143772094	3	1	145	1	0	0	0	0	1	0	0	0	11032	623	22	4	784	4	OR2A25	7	143772094	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	13823931	143772094	15366569	189	26609											
C7orf33	202865	broad.mit.edu	37	chr7	148311217	148311217	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	accaaatctggtgccccgtgGcattttctttctcaaggtcc	7	13	8	13	1	3	0	1	0	3	0	5	0	4	0	4	3	1	1	4	3	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:148311217G>T	uc003wew.2	+	2	649	c.288G>T	c.(286-288)TGG>TGT	p.W96C		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	96										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GTGCCCCGTGGCATTTTCTTT	0.517													27	57					8.24728e-16	1.33901e-15	1	0	T	148311217	T	T	148311217	3	4	145	1	0	0	0	0	1	0	0	0	2399	1212	42	4	294	4	C7orf33	7	148311217	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4539123	148311217	10827446	190	26610											
GIMAP6	474344	broad.mit.edu	37	chr7	150325508	150325508	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagacgtccctgccgaggaTgctgtttcctgttgcactct	6	12	11	12	2	1	1	0	0	1	1	3	4	3	2	3	1	3	4	3	1	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:150325508T>C	uc003whn.2	-	3	602	c.178A>G	c.(178-180)ATC>GTC	p.I60V	GIMAP6_uc003whm.2_Intron	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	60							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGCCGAGGATGCTGTTTCCT	0.547													20	477					0	0	0	0	C	150325508	C	C	150325508	3	2	145	1	0	0	0	0	1	0	0	0	6420	1464	51	5	704	5	GIMAP6	7	150325508	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	2014291	150325508	8813155	191	26611											
ABP1	26	broad.mit.edu	37	chr7	150557669	150557669	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaacgacccctggcaccCgcccgtggtctttgagcagt	7	7	11	16	3	1	2	0	1	1	1	1	3	1	2	5	2	2	2	5	2	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:150557669C>A	uc003why.1	+	5	6155	c.1937C>A	c.(1936-1938)CCG>CAG	p.P646Q	ABP1_uc003whz.1_Missense_Mutation_p.P646Q|ABP1_uc003wia.1_Missense_Mutation_p.P665Q	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	646					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	CCCTGGCACCCGCCCGTGGTC	0.617													81	73					1.3515e-34	2.45602e-34	1	0	A	150557669	A	A	150557669	3	1	145	1	0	0	0	0	1	0	0	0	98	652	23	3	1947	3	ABP1	7	150557669	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	232161	150557669	8580994	192	26612											
UNC5D	137970	broad.mit.edu	37	chr8	35608237	35608237	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgtgccgtgaagcaactGaaggtggcggtttttggctg	7	11	16	7	2	0	2	0	2	0	0	0	3	0	2	1	4	3	3	1	4	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:35608237G>T	uc003xjr.1	+	13	2401	c.2073G>T	c.(2071-2073)CTG>CTT	p.L691L	UNC5D_uc003xjs.1_Silent_p.L686L|UNC5D_uc003xju.1_Silent_p.L267L	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	691	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGAAGCAACTGAAGGTGGCGG	0.507													31	306					5.45727e-16	8.88046e-16	1	0	T	35608237	T	T	35608237	2	4	145	1	0	0	0	0	0	0	0	1	17063	1277	45	2		2	UNC5D	8	35608237	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08		35608237	110755785	193	26613											
UNC5D	137970	broad.mit.edu	37	chr8	35624547	35624547	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattcggcagctcaaaggccAtgaacagatcctccaagtgc	12	7	9	13	1	1	2	1	1	0	1	4	2	3	2	3	2	3	2	3	2	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:35624547A>G	uc003xjr.1	+	15	2769	c.2441A>G	c.(2440-2442)CAT>CGT	p.H814R	UNC5D_uc003xjs.1_Missense_Mutation_p.H809R|UNC5D_uc003xju.1_Missense_Mutation_p.H390R	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	814	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CTCAAAGGCCATGAACAGATC	0.507													93	121					0	0	0	0	G	35624547	G	G	35624547	3	3	145	1	0	0	0	0	1	0	0	0	17063	217	8	5	2499	5	UNC5D	8	35624547	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	16310	35624547	110739475	194	26614											
MYST3	7994	broad.mit.edu	37	chr8	41792081	41792081	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctccttcctctcctcgggTaggggcatgtcttcttttgg	2	16	10	13	1	3	0	0	0	3	0	8	0	6	0	4	4	0	2	4	4	1	5	rs7820342		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:41792081T>C	uc010lxb.2	-	18	4201	c.3657A>G	c.(3655-3657)CTA>CTG	p.L1219L	MYST3_uc010lxc.2_Silent_p.L1219L|MYST3_uc003xon.3_Silent_p.L1219L	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1219					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			tctcctcGGGTAGGGGCATGT	0.343													58	67					0	0	0	0	C	41792081	C	C	41792081	2	2	145	1	0	0	0	0	0	0	0	1	10157	1625	57	5		5	MYST3	8	41792081	Silent	SNP	T	TCGA-CR-7374-01A-11D-2012-08	6167534	41792081	104571941	195	26615											
YTHDF3	253943	broad.mit.edu	37	chr8	64099575	64099575	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcagcaacaaggacctcagCcacaggcccagcctcaccaa	14	2	8	17	0	2	0	2	0	0	0	2	1	2	1	5	2	5	2	5	2	3	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:64099575C>T	uc003xuy.2	+	5	1322	c.1006C>T	c.(1006-1008)CCA>TCA	p.P336S	YTHDF3_uc010lys.2_Missense_Mutation_p.P280S|YTHDF3_uc003xuz.2_Missense_Mutation_p.P280S|YTHDF3_uc003xva.2_Missense_Mutation_p.P280S|YTHDF3_uc011len.1_Missense_Mutation_p.P280S	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	336											0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			AGGACCTCAGCCACAGGCCCA	0.567													14	31					0	0	0	0	T	64099575	T	T	64099575	3	4	145	1	0	0	0	0	1	0	0	0	17568	738	26	4	1019	4	YTHDF3	8	64099575	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	22307494	64099575	82264447	196	26616											
PREX2	80243	broad.mit.edu	37	chr8	69005862	69005862	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agattccatacaatgggtttAtaatagcattgagagtgctc	13	13	9	6	0	0	2	0	1	0	2	2	3	1	2	1	1	3	3	1	1	5	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:69005862A>T	uc003xxv.1	+	21	2300	c.2273A>T	c.(2272-2274)TAT>TTT	p.Y758F	PREX2_uc003xxu.1_Missense_Mutation_p.Y758F|PREX2_uc011lez.1_Missense_Mutation_p.Y693F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	758					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CAATGGGTTTATAATAGCATT	0.438													49	101					0	0	0	0	T	69005862	T	T	69005862	3	4	145	1	0	0	0	0	1	0	0	0	12539	449	16	5	2355	5	PREX2	8	69005862	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	4906287	69005862	77358160	197	26617											
KIAA1429	25962	broad.mit.edu	37	chr8	95547138	95547138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggaggtggtggtggtggaGagtctctgtcatgacttatc	6	13	17	5	0	2	2	1	1	1	1	4	4	2	3	0	6	0	0	0	6	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:95547138G>A	uc003ygo.1	-	5	426	c.413C>T	c.(412-414)TCT>TTT	p.S138F	KIAA1429_uc003ygp.2_Missense_Mutation_p.S138F	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	138					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			tggtggtggAGAGTCTCTGTC	0.353													41	109					0	0	0	0	A	95547138	A	A	95547138	3	1	145	1	0	0	0	0	1	0	0	0	8270	942	33	2	5159	2	KIAA1429	8	95547138	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	26541276	95547138	50816884	198	26618											
UBR5	51366	broad.mit.edu	37	chr8	103335611	103335611	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctaagttgaaatctacagCtgtcattcatattccaaact	14	14	4	9	0	4	1	2	1	2	0	5	1	5	1	1	0	3	2	1	0	5	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:103335611C>A	uc003ykr.1	-	14	1745	c.1712G>T	c.(1711-1713)AGC>ATC	p.S571I	UBR5_uc003yks.1_Missense_Mutation_p.S571I	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	571					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AAATCTACAGCTGTCATTCAT	0.363													15	44					0.00244969	0.00355777	1	0	A	103335611	A	A	103335611	3	1	145	1	0	0	0	0	1	0	0	0	16973	797	28	4	6871	4	UBR5	8	103335611	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	7788473	103335611	43028411	199	26619											
KCNV1	27012	broad.mit.edu	37	chr8	110980568	110980568	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aataggcaaggccaagacaaGaattcccgataatatacaca	19	6	7	9	1	0	2	0	0	0	2	1	3	1	2	2	2	1	1	2	2	9	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:110980568G>A	uc003ynr.3	-	3	1594	c.1252C>T	c.(1252-1254)CTT>TTT	p.L418F	KCNV1_uc010mcw.2_Missense_Mutation_p.L418F	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	418	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GCCAAGACAAGAATTCCCGAT	0.478													51	113					0	0	0	0	A	110980568	A	A	110980568	3	1	145	1	0	0	0	0	1	0	0	0	8133	942	33	2	254	2	KCNV1	8	110980568	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	7644957	110980568	35383454	200	26620											
CSMD3	114788	broad.mit.edu	37	chr8	113668540	113668540	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggcccatcatgaacttcCagaacatcataattcagttc	12	13	5	11	0	3	2	3	1	0	1	5	2	4	2	2	1	2	1	2	1	3	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:113668540C>G	uc003ynu.2	-	18	3006	c.2847G>C	c.(2845-2847)CTG>CTC	p.L949L	CSMD3_uc003yns.2_Silent_p.L221L|CSMD3_uc003ynt.2_Silent_p.L909L|CSMD3_uc011lhx.1_Silent_p.L845L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	949	Extracellular (Potential).|CUB 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATGAACTTCCAGAACATCAT	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			28	69					0	0	0	0	G	113668540	G	G	113668540	2	3	145	1	0	0	0	0	0	0	0	1	3963	581	21	4		4	CSMD3	8	113668540	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2687972	113668540	32695482	201	26621											
WISP1	8840	broad.mit.edu	37	chr8	134232922	134232922	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcacgtgcatcgacggcGcggtgggctgcacaccactg	7	6	14	14	5	0	0	0	0	0	0	1	1	0	0	1	3	3	4	1	3	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:134232922G>T	uc003yub.2	+	3	524	c.448G>T	c.(448-450)GCG>TCG	p.A150S	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	150	VWFC.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CATCGACGGCGCGGTGGGCTG	0.667													50	138					1.39843e-22	2.40691e-22	1	0	T	134232922	T	T	134232922	3	4	145	1	0	0	0	0	1	0	0	0	17440	1087	38	3	458	3	WISP1	8	134232922	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	20564382	134232922	12131100	202	26622											
GLI4	2738	broad.mit.edu	37	chr8	144358699	144358699	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccaacctggtgcgccacCagcggctgcacacgggtgag	7	5	14	15	3	0	1	0	1	0	0	1	1	1	1	4	3	4	3	4	3	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:144358699C>T	uc003yxx.2	+	4	941	c.856C>T	c.(856-858)CAG>TAG	p.Q286*	ZFP41_uc003yxv.2_RNA	NM_138465	NP_612474	P10075	GLI4_HUMAN	GLI-Kruppel family member GLI4	286	C2H2-type 4.					nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GGTGCGCCACCAGCGGCTGCA	0.657													21	35					0	0	0	0	T	144358699	T	T	144358699	4	4	145	1	0	0	0	0	0	1	0	0	6477	595	21	4	866	4	GLI4	8	144358699	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	10125777	144358699	2005323	203	26623											
RHPN1	114822	broad.mit.edu	37	chr8	144463846	144463846	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacgcttcggggagactcGcctgtcctcatcgctgccgt	4	10	11	16	5	2	1	2	0	0	1	6	2	3	1	3	2	1	2	3	2	0	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:144463846G>A	uc003yyb.2	+	13	1726	c.1593G>A	c.(1591-1593)TCG>TCA	p.S531S		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	556	PDZ.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			GGGGAGACTCGCCTGTCCTCA	0.692													23	39					0	0	0	0	A	144463846	A	A	144463846	2	1	145	1	0	0	0	0	0	0	0	1	13415	1074	38	1		1	RHPN1	8	144463846	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	105147	144463846	1900176	204	26624											
KANK1	23189	broad.mit.edu	37	chr9	712501	712501	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggagagggtggaaatgcatGaccgatgtgctgggaggtct	10	8	18	5	1	1	2	0	1	1	1	1	6	1	4	1	5	2	2	1	5	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:712501G>C	uc003zgl.1	+	7	2384	c.1735G>C	c.(1735-1737)GAC>CAC	p.D579H	KANK1_uc003zgm.2_Missense_Mutation_p.D579H|KANK1_uc003zgn.1_Missense_Mutation_p.D579H|KANK1_uc003zgo.1_Missense_Mutation_p.D579H|KANK1_uc003zgp.1_Missense_Mutation_p.D579H|KANK1_uc003zgq.2_Missense_Mutation_p.D421H|KANK1_uc003zgr.1_Missense_Mutation_p.D421H|KANK1_uc003zgs.1_Missense_Mutation_p.D421H	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	579					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GGAAATGCATGACCGATGTGC	0.507													30	196					0	0	0	0	C	712501	C	C	712501	3	2	145	1	0	0	0	0	1	0	0	0	8015	1290	45	2	1741	2	KANK1	9	712501	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08		712501	140500930	205	26625											
DNAI1	27019	broad.mit.edu	37	chr9	34493300	34493300	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcagggaagatggccatgAggaagctgacatctatggag	14	7	14	6	0	2	3	1	2	1	1	2	6	2	6	1	4	1	1	1	4	4	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:34493300A>G	uc003zum.2	+	9	983	c.790A>G	c.(790-792)AGG>GGG	p.R264G		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	264					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		GATGGCCATGAGGAAGCTGAC	0.478									Kartagener_syndrome				39	53					0	0	0	0	G	34493300	G	G	34493300	3	3	145	1	0	0	0	0	1	0	0	0	4631	295	11	5	824	5	DNAI1	9	34493300	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	33780799	34493300	106720131	206	26626											
TLN1	7094	broad.mit.edu	37	chr9	35706887	35706887	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttcacactccagctgccctgGagccttgtccctgcagacac	7	9	8	17	0	1	1	1	0	0	1	3	2	3	2	4	1	4	2	4	1	0	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:35706887G>C	uc003zxt.2	-	38	5320	c.4966C>G	c.(4966-4968)CCA>GCA	p.P1656A		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1656	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGCTGCCCTGGAGCCTTGTCC	0.582													4	116					0	0	0	0	C	35706887	C	C	35706887	3	2	145	1	0	0	0	0	1	0	0	0	16013	1174	41	2	2739	2	TLN1	9	35706887	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1213587	35706887	105506544	207	26627											
FLJ46321	389763	broad.mit.edu	37	chr9	84609741	84609741	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtgcatgtcagagcagaGcctgtccagggctgtccctg	8	8	14	11	0	1	2	1	0	0	2	3	3	3	2	3	1	3	3	3	1	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:84609741G>A	uc004amn.2	+	4	4403	c.4356G>A	c.(4354-4356)GAG>GAA	p.E1452E		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1452						integral to membrane					0						TCAGAGCAGAGCCTGTCCAGG	0.532													33	37					0	0	0	0	A	84609741	A	A	84609741	2	1	145	1	0	0	0	0	0	0	0	1	5964	962	34	4		4	FLJ46321	9	84609741	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	48902854	84609741	56603690	208	26628											
OR13C4	138804	broad.mit.edu	37	chr9	107288743	107288743	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagatggtaccataaaataTgatcaccacagtcaggtgag	16	8	10	7	0	2	3	2	2	0	1	2	4	2	3	2	2	1	1	2	2	5	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:107288743T>C	uc011lvn.1	-	1	748	c.748A>G	c.(748-750)ATA>GTA	p.I250V		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CCATAAAATATGATCACCACA	0.453													80	63					0	0	0	0	C	107288743	C	C	107288743	3	2	145	1	0	0	0	0	1	0	0	0	10990	1464	51	5	210	5	OR13C4	9	107288743	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	22679002	107288743	33924688	209	26629											
ABCA1	19	broad.mit.edu	37	chr9	107586827	107586827	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccagtaggacttggtgcaagGaaaataccagggcctgggaa	13	6	14	8	0	0	0	0	0	0	0	0	3	0	3	3	5	2	2	3	5	6	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:107586827G>A	uc004bcl.2	-	18	2888	c.2575C>T	c.(2575-2577)CCT>TCT	p.P859S		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	859					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTGGTGCAAGGAAAATACCAG	0.507													56	38					0	0	0	0	A	107586827	A	A	107586827	3	1	145	1	0	0	0	0	1	0	0	0	28	1174	41	2	4342	2	ABCA1	9	107586827	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	298084	107586827	33626604	210	26630											
TTC16	158248	broad.mit.edu	37	chr9	130485521	130485521	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgccaagatgcggggatcCtggctgtgcagggcaagctg	7	6	17	11	3	0	1	0	0	0	1	1	2	1	2	2	4	3	4	2	4	2	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:130485521C>T	uc004brq.1	+	7	848	c.781C>T	c.(781-783)CTG>TTG	p.L261L	PTRH1_uc011mah.1_Intron|TTC16_uc011mai.1_Silent_p.L248L|TTC16_uc004brr.1_Silent_p.L206L|TTC16_uc010mxn.1_5'UTR	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	261	TPR 4.						binding				0						TGCGGGGATCCTGGCTGTGCA	0.632													41	22					0	0	0	0	T	130485521	T	T	130485521	2	4	145	1	0	0	0	0	0	0	0	1	16751	680	24	4		4	TTC16	9	130485521	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	22898694	130485521	10727910	211	26631											
NUP188	23511	broad.mit.edu	37	chr9	131768858	131768858	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccactggtgtcctcccctcGccgcagggcaagtccacctc	5	7	10	19	2	0	0	0	0	0	0	5	0	3	0	7	2	0	2	7	2	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:131768858G>A	uc004bws.1	+	44	5173	c.5151G>A	c.(5149-5151)TCG>TCA	p.S1717S		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1717					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TCCTCCCCTCGCCGCAGGGCA	0.612											OREG0019528	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	79	53					0	0	0	0	A	131768858	A	A	131768858	2	1	145	1	0	0	0	0	0	0	0	1	10812	1074	38	1		1	NUP188	9	131768858	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1283337	131768858	9444573	212	26632											
DBH	1621	broad.mit.edu	37	chr9	136522303	136522303	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaggccctgtacagcttCgcgcccatctccatgcactg	7	9	9	16	2	1	1	0	1	1	0	3	1	1	1	3	1	3	3	3	1	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:136522303C>A	uc004cel.2	+	11	1683	c.1674C>A	c.(1672-1674)TTC>TTA	p.F558L	uc010nao.1_Silent_p.A26A	NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	558	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	TGTACAGCTTCGCGCCCATCT	0.632													38	57					2.87052e-16	4.68176e-16	1	0	A	136522303	A	A	136522303	3	1	145	1	0	0	0	0	1	0	0	0	4267	883	31	3	1716	3	DBH	9	136522303	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	4753445	136522303	4691128	213	26633											
GATA3	2625	broad.mit.edu	37	chr10	8100437	8100437	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgtctaccccccggcctcGtcctcctccttgtcgggggg	1	10	11	19	4	1	0	0	0	1	0	7	0	5	0	8	4	1	0	8	4	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:8100437G>A	uc001ika.2	+	3	968	c.411G>A	c.(409-411)TCG>TCA	p.S137S	GATA3_uc001ijz.2_Silent_p.S137S	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	137	Poly-Ser.				aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						CCCCGGCCTCGTCCTCCTCCT	0.716			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						51	120					0	0	0	0	A	8100437	A	A	8100437	2	1	145	1	0	0	0	0	0	0	0	1	6290	1132	40	1		1	GATA3	10	8100437	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08		8100437	127434310	214	26634											
ACBD7	414149	broad.mit.edu	37	chr10	15120601	15120601	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtcgcatcttccgtcgacaaCcctagaaagatacaaacagg	14	7	8	12	3	1	2	0	0	1	2	4	3	2	2	2	1	3	1	2	1	5	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:15120601C>A	uc001inv.2	-	4	243	c.195G>T	c.(193-195)GGG>GGT	p.G65G	ACBD7_uc010qby.1_Intron	NM_001039844	NP_001034933	Q8N6N7	ACBD7_HUMAN	acyl-Coenzyme A binding domain containing 7	65	ACB.						fatty-acyl-CoA binding				0						CCGTCGACAACCCTAGAAAGA	0.363													56	115					4.48484e-38	8.21264e-38	1	0	A	15120601	A	A	15120601	2	1	145	1	0	0	0	0	0	0	0	1	127	521	18	4		4	ACBD7	10	15120601	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	7020164	15120601	120414146	215	26635											
NEBL	10529	broad.mit.edu	37	chr10	21139430	21139430	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catattcttctttatatttcAccttcattggaaaaagaaaa	15	16	3	7	0	4	1	2	0	2	1	4	2	4	2	1	1	0	0	1	1	7	9			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:21139430A>G	uc001iqi.2	-	11	1407	c.1010T>C	c.(1009-1011)GTG>GCG	p.V337A	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	337	Nebulin 9.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TTTATATTTCACCTTCATTGG	0.318													3	117					0	0	0	0	G	21139430	G	G	21139430	3	3	145	1	0	0	0	0	1	0	0	0	10357	173	6	5	2106	5	NEBL	10	21139430	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	6018829	21139430	114395317	216	26636											
ARHGAP21	57584	broad.mit.edu	37	chr10	24884718	24884718	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttatcacattcaaatctcGccatttctaggtgtacaaaa	13	13	5	10	1	4	0	2	0	2	0	5	0	4	0	1	1	1	2	1	1	6	5	rs149363020		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:24884718G>A	uc001isb.2	-	19	4127	c.3640C>T	c.(3640-3642)CGA>TGA	p.R1214*	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1213	Rho-GAP.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TTCAAATCTCGCCATTTCTAG	0.358													27	55					0	0	0	0	A	24884718	A	A	24884718	4	1	145	1	0	0	0	0	0	1	0	0	871	1095	38	1	2268	1	ARHGAP21	10	24884718	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3745288	24884718	110650029	217	26637											
YME1L1	10730	broad.mit.edu	37	chr10	27434503	27434503	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcagataatccaaggtccCttaagttaagtgaaggctgt	12	12	10	7	0	1	2	1	1	0	1	3	2	3	2	2	2	0	3	2	2	5	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:27434503C>T	uc001iti.2	-	4	538	c.356G>A	c.(355-357)AGG>AAG	p.R119K	YME1L1_uc001itj.2_Missense_Mutation_p.R62K|YME1L1_uc010qdl.1_Missense_Mutation_p.R62K|YME1L1_uc009xkv.2_RNA|YME1L1_uc001itk.1_3'UTR	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	119					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						TCCAAGGTCCCTTAAGTTAAG	0.333													21	77					0	0	0	0	T	27434503	T	T	27434503	3	4	145	1	0	0	0	0	1	0	0	0	17555	681	24	4	2033	4	YME1L1	10	27434503	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2549785	27434503	108100244	218	26638											
ANKRD30A	91074	broad.mit.edu	37	chr10	37438733	37438733	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaatgcaaaactctgttcCaaataaagcctttgaattga	16	12	6	7	0	1	3	0	3	1	0	2	3	2	3	2	0	3	2	2	0	7	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:37438733C>A	uc001iza.1	+	11	1532	c.1433C>A	c.(1432-1434)CCA>CAA	p.P478Q		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	534						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AACTCTGTTCCAAATAAAGCC	0.294													48	107					3.76997e-23	6.53583e-23	1	0	A	37438733	A	A	37438733	3	1	145	1	0	0	0	0	1	0	0	0	658	594	21	4	1475	4	ANKRD30A	10	37438733	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	10004230	37438733	98096014	219	26639											
FRMPD2	143162	broad.mit.edu	37	chr10	49414961	49414961	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaccagcacaccgtattctgGgagctgctgagtgacctgga	10	8	12	11	1	1	2	0	2	1	0	1	4	1	4	3	2	4	4	3	2	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:49414961G>T	uc001jgi.2	-	14	1734	c.1627C>A	c.(1627-1629)CCA>ACA	p.P543T	FRMPD2_uc001jgh.2_Missense_Mutation_p.P511T|FRMPD2_uc001jgj.2_Missense_Mutation_p.P521T	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	543	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CCGTATTCTGGGAGCTGCTGA	0.498													21	48					5.35047e-06	8.04819e-06	1	0	T	49414961	T	T	49414961	3	4	145	1	0	0	0	0	1	0	0	0	6092	1232	43	4	2366	4	FRMPD2	10	49414961	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	11976228	49414961	86119786	220	26640											
PCDH15	65217	broad.mit.edu	37	chr10	55782945	55782945	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgaccatttattccagcatCagggtctgttgcctattaaa	10	15	7	9	0	2	1	1	1	1	0	3	1	3	1	3	1	2	2	3	1	4	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:55782945C>T	uc001jju.1	-	19	2628	c.2233G>A	c.(2233-2235)GAT>AAT	p.D745N	PCDH15_uc010qhq.1_Missense_Mutation_p.D750N|PCDH15_uc010qhr.1_Missense_Mutation_p.D745N|PCDH15_uc010qhs.1_Missense_Mutation_p.D757N|PCDH15_uc010qht.1_Missense_Mutation_p.D752N|PCDH15_uc010qhu.1_Missense_Mutation_p.D745N|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.D745N|PCDH15_uc010qhw.1_Missense_Mutation_p.D708N|PCDH15_uc010qhx.1_Missense_Mutation_p.D674N|PCDH15_uc010qhy.1_Missense_Mutation_p.D750N|PCDH15_uc010qhz.1_Missense_Mutation_p.D745N|PCDH15_uc010qia.1_Missense_Mutation_p.D723N|PCDH15_uc010qib.1_Missense_Mutation_p.D723N|PCDH15_uc001jjw.2_Missense_Mutation_p.D745N	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	745	Extracellular (Potential).|Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATTCCAGCATCAGGGTCTGTT	0.338										HNSCC(58;0.16)			9	59					0	0	0	0	T	55782945	T	T	55782945	3	4	145	1	0	0	0	0	1	0	0	0	11565	826	29	2	5313	2	PCDH15	10	55782945	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	6367984	55782945	79751802	221	26641											
RHOBTB1	9886	broad.mit.edu	37	chr10	62648067	62648067	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatgaaggcttccttgttCatgatgttttccaccatcat	8	17	6	10	0	3	2	3	2	0	0	5	2	5	2	3	1	0	3	3	1	1	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:62648067C>A	uc001jli.2	-	7	1797	c.1359G>T	c.(1357-1359)ATG>ATT	p.M453I	RHOBTB1_uc001jlh.2_Missense_Mutation_p.M453I|RHOBTB1_uc001jlj.2_Missense_Mutation_p.M453I|RHOBTB1_uc001jlk.2_Missense_Mutation_p.M453I|RHOBTB1_uc009xpe.1_Missense_Mutation_p.M391I|RHOBTB1_uc001jll.2_Missense_Mutation_p.M203I	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	453					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					CTTCCTTGTTCATGATGTTTT	0.483													28	91					1.50538e-07	2.2933e-07	1	0	A	62648067	A	A	62648067	3	1	145	1	0	0	0	0	1	0	0	0	13398	826	29	2	755	2	RHOBTB1	10	62648067	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	6865122	62648067	72886680	222	26642											
LRRTM3	347731	broad.mit.edu	37	chr10	68687192	68687192	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taactccctgagaaccatccCtgtgcgaatattccaagact	12	10	6	13	1	0	2	0	1	0	2	3	4	3	2	4	0	3	0	4	0	5	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:68687192C>T	uc001jmz.1	+	2	1068	c.518C>T	c.(517-519)CCT>CTT	p.P173L	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.P173L	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	173	Extracellular (Potential).|LRR 5.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						AGAACCATCCCTGTGCGAATA	0.488													17	195					0	0	0	0	T	68687192	T	T	68687192	3	4	145	1	0	0	0	0	1	0	0	0	9091	681	24	4	524	4	LRRTM3	10	68687192	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	6039125	68687192	66847555	223	26643											
TET1	80312	broad.mit.edu	37	chr10	70406353	70406353	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattctcaggtacagttaacGgtgaatgccaatcagaaagc	15	9	9	8	1	2	2	2	1	1	1	3	2	2	2	1	2	4	2	1	2	6	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:70406353G>A	uc001jok.3	+	4	4372	c.3867G>A	c.(3865-3867)ACG>ACA	p.T1289T		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1289					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TACAGTTAACGGTGAATGCCA	0.458													8	166					0	0	0	0	A	70406353	A	A	70406353	2	1	145	1	0	0	0	0	0	0	0	1	15835	1103	39	1		1	TET1	10	70406353	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1719161	70406353	65128394	224	26644											
OIT3	170392	broad.mit.edu	37	chr10	74673213	74673213	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttctctctcaagacatgtgGtacagtggtcgatgtaggtt	8	14	11	8	1	2	1	1	0	2	1	5	2	2	1	0	3	1	3	0	3	3	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:74673213G>T	uc001jte.1	+	6	1156	c.938G>T	c.(937-939)GGT>GTT	p.G313V	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	313	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					AAGACATGTGGTACAGTGGTC	0.557													39	114					1.57019e-19	2.62065e-19	1	0	T	74673213	T	T	74673213	3	4	145	1	0	0	0	0	1	0	0	0	10903	1261	44	4	960	4	OIT3	10	74673213	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4266860	74673213	60861534	225	26645											
ANXA7	310	broad.mit.edu	37	chr10	75139821	75139821	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccatggtagctctcagctGaggaaagcttcttgtggcaa	9	11	11	10	0	2	1	1	1	2	0	4	2	3	2	1	3	3	5	1	3	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:75139821G>A	uc001jtz.2	-	11	1196	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	ANXA7_uc001jua.2_Nonsense_Mutation_p.Q353*|ANXA7_uc001jub.2_Nonsense_Mutation_p.Q313*|ANXA7_uc010qki.1_Nonsense_Mutation_p.Q263*|ANXA7_uc009xre.2_Nonsense_Mutation_p.Q282*|ANXA7_uc009xrf.1_Nonsense_Mutation_p.Q295*	NM_004034	NP_004025	P20073	ANXA7_HUMAN	annexin VII isoform 2	375	Annexin 3.						calcium ion binding|calcium-dependent phospholipid binding|calcium-dependent protein binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					GCTCTCAGCTGAGGAAAGCTT	0.428													101	344					0	0	0	0	A	75139821	A	A	75139821	4	1	145	1	0	0	0	0	0	1	0	0	723	1299	45	2	359	2	ANXA7	10	75139821	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	466608	75139821	60394926	226	26646											
USP54	159195	broad.mit.edu	37	chr10	75277422	75277422	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcaggtgaatggaagaaaGaactggccccaaactctgta	16	6	11	8	0	1	3	0	1	1	2	1	4	1	4	2	3	3	2	2	3	7	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:75277422G>C	uc001juo.2	-	18	2779	c.2762C>G	c.(2761-2763)TCT>TGT	p.S921C	USP54_uc010qkk.1_Missense_Mutation_p.S103C|USP54_uc001juk.2_Missense_Mutation_p.S9C|USP54_uc001jul.2_Missense_Mutation_p.S9C|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	921					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					ATGGAAGAAAGAACTGGCCCC	0.512													18	87					0	0	0	0	C	75277422	C	C	75277422	3	2	145	1	0	0	0	0	1	0	0	0	17153	942	33	2	2312	2	USP54	10	75277422	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	137601	75277422	60257325	227	26647											
PTEN	5728	broad.mit.edu	37	chr10	89624270	89624270	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgttagcagaaacaaaaggaGatatcaagaggatggattcg	17	7	12	5	2	1	3	1	0	0	3	2	6	1	5	0	3	2	2	0	3	6	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:89624270G>C	uc001kfb.2	+	2	1075	c.44G>C	c.(43-45)AGA>ACA	p.R15T	KILLIN_uc009xti.2_5'Flank	NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	15	Phosphatase tensin-type.		R -> S (in glioma).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(13)|p.0?(12)|p.R15I(4)|p.R15S(3)|p.R15K(1)|p.R14fs*26(1)|p.R15fs*28(1)|p.R15fs*9(1)|p.N12fs*6(1)|p.R14_D22del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AACAAAAGGAGATATCAAGAG	0.478		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			15	129					0	0	0	0	C	89624270	C	C	89624270	3	2	145	1	0	0	0	0	1	0	0	0	12800	942	33	2	46	2	PTEN	10	89624270	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	14346848	89624270	45910477	228	26648											
TMEM20	159371	broad.mit.edu	37	chr10	95658490	95658490	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaatgctagttgttatccCttgcttaatatacagaaagt	13	14	6	8	0	0	1	0	0	0	1	1	1	1	1	2	0	3	4	2	0	7	7	rs78174634		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:95658490C>A	uc001kjg.1	+	2	402	c.341C>A	c.(340-342)CCT>CAT	p.P114H	TMEM20_uc001kji.2_Intron|TMEM20_uc001kjf.1_Missense_Mutation_p.P113H|TMEM20_uc001kjh.2_Intron|TMEM20_uc010qnw.1_Missense_Mutation_p.P97H|TMEM20_uc001kjj.2_Intron	NM_001134658	NP_001128130	Q2M3R5	TMM20_HUMAN	transmembrane protein 20 isoform 1	114	Helical; (Potential).|DUF6 1.					integral to membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;3.46e-05)|Renal(717;0.018)|Ovarian(717;0.0228)|all_hematologic(284;0.189)		STAD - Stomach adenocarcinoma(243;0.00345)		GTTGTTATCCCTTGCTTAATA	0.338													4	47					0.000602214	0.00087997	1	0	A	95658490	A	A	95658490	3	1	145	1	0	0	0	0	1	0	0	0	16188	681	24	4	347	4	TMEM20	10	95658490	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	6034220	95658490	39876257	229	26649											
ANO9	338440	broad.mit.edu	37	chr11	433389	433389	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaggctccaggaggaaaGtgcggtacaggccaaagaca	13	4	13	11	1	1	1	1	0	0	1	2	3	2	3	3	5	2	2	3	5	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:433389G>C	uc001lpi.2	-	4	360	c.275C>G	c.(274-276)ACT>AGT	p.T92S	ANO9_uc010qvv.1_5'UTR	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	92	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CAGGAGGAAAGTGCGGTACAG	0.647													45	40					0	0	0	0	C	433389	C	C	433389	3	2	145	1	0	0	0	0	1	0	0	0	704	1029	36	4	2153	4	ANO9	11	433389	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08		433389	134573127	230	26650											
EPS8L2	64787	broad.mit.edu	37	chr11	722549	722549	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagagctggatgcggccccGgtagggcagggcagagcagt	9	4	19	9	2	0	2	0	0	0	2	0	4	0	3	2	5	3	5	2	5	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:722549G>A	uc001lqt.2	+	13	1455	c.1208G>A	c.(1207-1209)CGT>CAT	p.R403H	EPS8L2_uc001lqu.2_Missense_Mutation_p.R403H|EPS8L2_uc010qwk.1_Missense_Mutation_p.R419H|EPS8L2_uc001lqv.2_Missense_Mutation_p.R358H|EPS8L2_uc001lqw.2_Missense_Mutation_p.R15H|EPS8L2_uc001lqx.2_Missense_Mutation_p.R15H|EPS8L2_uc001lqy.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	403						cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATGCGGCCCCGGTAGGGCAGG	0.687													24	22					0	0	0	0	A	722549	A	A	722549	3	1	145	1	0	0	0	0	1	0	0	0	5220	1130	39	1	1254	1	EPS8L2	11	722549	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	289160	722549	134283967	231	26651											
OR51S1	119692	broad.mit.edu	37	chr11	4870420	4870420	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctattgggggctatctGagttggtaatgttgacatag	8	14	14	5	0	1	2	0	2	1	0	1	2	1	2	0	3	1	6	0	3	4	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:4870420G>T	uc010qyo.1	-	1	19	c.19C>A	c.(19-21)CAG>AAG	p.Q7K		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGGGCTATCTGAGTTGGTAAT	0.483													50	120					9.22156e-22	1.57581e-21	1	0	T	4870420	T	T	4870420	3	4	145	1	0	0	0	0	1	0	0	0	11159	1299	45	2	955	2	OR51S1	11	4870420	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4147871	4870420	130136096	232	26652											
OR52A4	390053	broad.mit.edu	37	chr11	5142452	5142452	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggtccagagccatggctagCaggactcctgattcaatgcc	9	8	11	13	1	1	2	1	1	0	1	3	3	3	3	4	3	3	2	4	3	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:5142452C>A	uc001lzz.1	-	1	357	c.357G>T	c.(355-357)CTG>CTT	p.L119L	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CCATGGCTAGCAGGACTCCTG	0.438													13	73					1.05317e-09	1.64644e-09	1	0	A	5142452	A	A	5142452	2	1	145	1	0	0	0	0	0	0	0	1	11163	697	25	4		4	OR52A4	11	5142452	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	272032	5142452	129864064	233	26653											
DENND5A	23258	broad.mit.edu	37	chr11	9161320	9161320	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgacaagtgtatggtctttGatcagtgccacatcctcata	10	14	8	9	0	3	2	2	2	1	0	4	2	4	2	2	1	1	1	2	1	3	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:9161320G>C	uc001mhl.2	-	23	4017	c.3762C>G	c.(3760-3762)ATC>ATG	p.I1254M	DENND5A_uc001mhk.2_Missense_Mutation_p.I597M|DENND5A_uc010rbw.1_3'UTR	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	1254	RUN 2.									liver(1)	1						TATGGTCTTTGATCAGTGCCA	0.527													8	68					0	0	0	0	C	9161320	C	C	9161320	3	2	145	1	0	0	0	0	1	0	0	0	4458	1280	45	2	105	2	DENND5A	11	9161320	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4018868	9161320	125845196	234	26654											
KCNJ11	3767	broad.mit.edu	37	chr11	17409546	17409546	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttggacacaaagcgggccctCcgctggcgggcacggtacct	7	6	14	14	4	0	0	0	0	0	0	1	1	1	1	3	5	2	3	3	5	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:17409546C>T	uc001mna.2	-	1	661	c.93G>A	c.(91-93)CGG>CGA	p.R31R	KCNJ11_uc001mnb.3_Intron	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	31						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		AGCGGGCCCTCCGCTGGCGGG	0.652													14	157					0	0	0	0	T	17409546	T	T	17409546	2	4	145	1	0	0	0	0	0	0	0	1	8084	842	30	2		2	KCNJ11	11	17409546	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	8248226	17409546	117596970	235	26655											
ABCC8	6833	broad.mit.edu	37	chr11	17427052	17427052	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctgtacctggtcgatggTgttacagtcagatgaaaatc	10	12	10	9	1	2	2	1	1	1	1	4	3	2	2	2	2	2	2	2	2	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:17427052T>C	uc001mnc.2	-	27	3514	c.3388A>G	c.(3388-3390)ACC>GCC	p.T1130A		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1130	Cytoplasmic (By similarity).|ABC transmembrane type-1 2.		T -> P (in HHF1).		carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGGTCGATGGTGTTACAGTCA	0.542													54	191					0	0	0	0	C	17427052	C	C	17427052	3	2	145	1	0	0	0	0	1	0	0	0	58	1696	59	5	1409	5	ABCC8	11	17427052	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	17506	17427052	117579464	236	26656											
SPTY2D1	144108	broad.mit.edu	37	chr11	18636297	18636298	+	Frame_Shift_Ins	INS	-	T	T																															ctggtcttcctgggactgaaINSttactgacagtccgtccagc																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:18636297_18636298insT	uc001moy.2	-	3	1739_1740	c.1523_1524insA	c.(1522-1524)AATfs	p.N508fs	SPTY2D1_uc010rdi.1_Frame_Shift_Ins_p.N508fs	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	508	Ser-rich.									breast(1)	1						CTGGGACTGAATTACTGACAGT	0.559													---	---	---								T	18636298	T	T	18636297	7	5	145	1	0	1	1	0	0	0	0	0	15192	98	4	0	549	0	SPTY2D1	11	18636297	Frame_Shift_Ins	INS	-	TCGA-CR-7374-01A-11D-2012-08	1209245	18636297	116370219	237	26657											
MRGPRX2	117194	broad.mit.edu	37	chr11	19077336	19077336	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagaggatcctgaccagcAgggccagactggacccacag	12	3	12	14	0	0	3	0	1	0	2	1	5	1	5	4	3	1	1	4	3	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:19077336A>T	uc001mph.2	-	2	702	c.614T>A	c.(613-615)CTG>CAG	p.L205Q		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	205	Helical; Name=5; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						CCTGACCAGCAGGGCCAGACT	0.547													24	48					0	0	0	0	T	19077336	T	T	19077336	3	4	145	1	0	0	0	0	1	0	0	0	9820	188	7	5	382	5	MRGPRX2	11	19077336	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	441039	19077336	115929180	238	26658											
NELL1	4745	broad.mit.edu	37	chr11	21592462	21592462	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtggagacaattggacccaTagctgtcagcagtgtcggtg	10	9	14	8	1	1	1	1	0	0	1	2	3	1	2	1	3	2	2	1	3	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:21592462T>A	uc001mqe.2	+	18	2286	c.2133T>A	c.(2131-2133)CAT>CAA	p.H711Q	NELL1_uc001mqf.2_Missense_Mutation_p.H664Q|NELL1_uc009yid.2_Missense_Mutation_p.H739Q|NELL1_uc010rdo.1_Missense_Mutation_p.H654Q|NELL1_uc010rdp.1_Missense_Mutation_p.H424Q|NELL1_uc001mqh.2_Missense_Mutation_p.H256Q	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	711	VWFC 4.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						ATTGGACCCATAGCTGTCAGC	0.448													62	168					0	0	0	0	A	21592462	A	A	21592462	3	1	145	1	0	0	0	0	1	0	0	0	10387	1403	49	5	2203	5	NELL1	11	21592462	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	2515126	21592462	113414054	239	26659											
SVIP	258010	broad.mit.edu	37	chr11	22848863	22848863	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctaaaattccccgagatgCagccttgaagaaatttgata	15	11	7	8	1	1	4	0	2	1	2	2	5	2	4	3	0	2	1	3	0	5	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:22848863C>A	uc001mqp.3	-	3	197	c.109G>T	c.(109-111)GCA>TCA	p.A37S	uc001mqq.1_5'Flank	NM_148893	NP_683691	Q8NHG7	SVIP_HUMAN	small VCP/p97-interacting protein	37						Golgi membrane|plasma membrane|smooth endoplasmic reticulum membrane					0						CCCCGAGATGCAGCCTTGAAG	0.353													37	137					1.69901e-12	2.70934e-12	1	0	A	22848863	A	A	22848863	3	1	145	1	0	0	0	0	1	0	0	0	15488	710	25	4	132	4	SVIP	11	22848863	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1256401	22848863	112157653	240	26660											
ANO3	63982	broad.mit.edu	37	chr11	26681844	26681844	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attaagtcattcatcgcataCctgattccagacgtaccaaa	14	11	5	11	2	2	2	2	1	0	1	4	2	3	2	3	0	2	2	3	0	4	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:26681844C>T	uc001mqt.3	+	27	2944	c.2799C>T	c.(2797-2799)TAC>TAT	p.Y933Y	ANO3_uc010rdr.1_Silent_p.Y917Y|ANO3_uc010rds.1_Silent_p.Y772Y|ANO3_uc010rdt.1_Silent_p.Y787Y	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	933	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCATCGCATACCTGATTCCAG	0.373													27	90					0	0	0	0	T	26681844	T	T	26681844	2	4	145	1	0	0	0	0	0	0	0	1	698	518	18	4		4	ANO3	11	26681844	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	3832981	26681844	108324672	241	26661											
SLC5A12	159963	broad.mit.edu	37	chr11	26742938	26742938	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttacctcataagtgctggtGataccagatctgtagaacac	12	11	8	10	0	2	3	1	1	1	2	2	3	2	3	2	1	4	2	2	1	5	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:26742938G>A	uc001mra.2	-	1	637	c.324C>T	c.(322-324)ATC>ATT	p.I108I	SLC5A12_uc001mrb.2_Intron|SLC5A12_uc001mrc.3_Silent_p.I108I	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	108	Cytoplasmic (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						AAGTGCTGGTGATACCAGATC	0.408													20	40					0	0	0	0	A	26742938	A	A	26742938	2	1	145	1	0	0	0	0	0	0	0	1	14728	1280	45	2		2	SLC5A12	11	26742938	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	61094	26742938	108263578	242	26662											
CD44	960	broad.mit.edu	37	chr11	35222735	35222735	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctacttcagacaaccacaagGatgactggtaatgggttctg	12	10	10	9	0	2	2	1	1	1	1	2	3	2	3	1	3	2	2	1	3	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:35222735G>A	uc001mvu.2	+	8	1463	c.1029G>A	c.(1027-1029)AGG>AGA	p.R343R	CD44_uc001mvv.2_Silent_p.R300R|CD44_uc001mvw.2_Intron|CD44_uc001mvx.2_Intron|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Intron|CD44_uc010rer.1_Intron|CD44_uc009ykh.2_Intron|CD44_uc010res.1_Intron|CD44_uc010ret.1_Intron|CD44_uc010reu.1_Intron	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	343	Extracellular (Potential).|Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	CAACCACAAGGATGACTGGTA	0.463													41	146					0	0	0	0	A	35222735	A	A	35222735	2	1	145	1	0	0	0	0	0	0	0	1	3032	1165	41	2		2	CD44	11	35222735	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	8479797	35222735	99783781	243	26663											
OR5L2	26338	broad.mit.edu	37	chr11	55595390	55595390	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagatacactctgcagaGagcaggcacaaagctttctc	13	8	9	11	0	2	3	0	1	2	2	3	4	2	3	0	1	4	4	0	1	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:55595390G>T	uc001nhy.1	+	1	696	c.696G>T	c.(694-696)GAG>GAT	p.E232D		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				ACTCTGCAGAGAGCAGGCACA	0.493										HNSCC(27;0.073)			61	130					3.21867e-24	5.63465e-24	1	0	T	55595390	T	T	55595390	3	4	145	1	0	0	0	0	1	0	0	0	11225	933	33	2	698	2	OR5L2	11	55595390	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	20372655	55595390	79411126	244	26664											
OR8H2	390151	broad.mit.edu	37	chr11	55872670	55872670	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggatgatattgataatccGcctggacctccagcttcaca	10	10	10	11	1	1	2	1	2	0	0	3	4	3	4	4	3	1	1	4	3	2	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:55872670G>T	uc010riy.1	+	1	152	c.152G>T	c.(151-153)CGC>CTC	p.R51L		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					TTGATAATCCGCCTGGACCTC	0.428										HNSCC(53;0.14)			80	277					5.42582e-32	9.73656e-32	1	0	T	55872670	T	T	55872670	3	4	145	1	0	0	0	0	1	0	0	0	11292	1087	38	3	154	3	OR8H2	11	55872670	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	277280	55872670	79133846	245	26665											
OR8H2	390151	broad.mit.edu	37	chr11	55872803	55872803	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaactatatttcctttacGggctgctttgcccagatgtt	7	16	7	11	1	0	1	0	0	0	1	2	1	2	1	3	1	4	3	3	1	4	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:55872803G>T	uc010riy.1	+	1	285	c.285G>T	c.(283-285)ACG>ACT	p.T95T		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					TTTCCTTTACGGGCTGCTTTG	0.443										HNSCC(53;0.14)			177	524					4.48366e-97	8.53803e-97	1	0	T	55872803	T	T	55872803	2	4	145	1	0	0	0	0	0	0	0	1	11292	1103	39	3		3	OR8H2	11	55872803	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	133	55872803	79133713	246	26666											
OR8K5	219453	broad.mit.edu	37	chr11	55927286	55927286	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgactgatgacattagagcCacagaaggtcaatgtaaaaa	18	8	9	6	0	1	5	1	3	0	2	1	5	1	5	1	1	1	1	1	1	6	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:55927286C>A	uc010rja.1	-	1	508	c.508G>T	c.(508-510)GGC>TGC	p.G170C		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ACATTAGAGCCACAGAAGGTC	0.388													50	86					8.0703e-11	1.27557e-10	1	0	A	55927286	A	A	55927286	3	1	145	1	0	0	0	0	1	0	0	0	11299	594	21	4	418	4	OR8K5	11	55927286	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	54483	55927286	79079230	247	26667											
OR5M9	390162	broad.mit.edu	37	chr11	56230512	56230512	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagagggttgcagccggcCatgtacctgtcaaaggccat	10	7	13	11	1	1	1	1	0	0	1	1	1	1	1	4	3	4	4	4	3	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:56230512C>A	uc010rjj.1	-	1	366	c.366G>T	c.(364-366)ATG>ATT	p.M122I		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TGCAGCCGGCCATGTACCTGT	0.493													53	125					1.00221e-16	1.63832e-16	1	0	A	56230512	A	A	56230512	3	1	145	1	0	0	0	0	1	0	0	0	11231	594	21	4	568	4	OR5M9	11	56230512	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	303226	56230512	78776004	248	26668											
MS4A14	84689	broad.mit.edu	37	chr11	60183849	60183849	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagttatggaagagaccaaaGaatggaaatctgaggaggaa	19	6	13	3	0	1	3	0	1	1	2	1	8	1	7	1	4	0	1	1	4	7	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:60183849G>C	uc001npj.2	+	5	1973	c.1408G>C	c.(1408-1410)GAA>CAA	p.E470Q	MS4A14_uc001npi.2_Missense_Mutation_p.E358Q|MS4A14_uc001npn.2_Missense_Mutation_p.E208Q|MS4A14_uc001npk.2_Missense_Mutation_p.E453Q|MS4A14_uc001npl.2_Missense_Mutation_p.E208Q|MS4A14_uc001npm.2_Missense_Mutation_p.E208Q	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	470	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						AGAGACCAAAGAATGGAAATC	0.388													9	114					0	0	0	0	C	60183849	C	C	60183849	3	2	145	1	0	0	0	0	1	0	0	0	9911	943	33	2	1426	2	MS4A14	11	60183849	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3953337	60183849	74822667	249	26669											
CPSF7	79869	broad.mit.edu	37	chr11	61179315	61179320	+	In_Frame_Del	DEL	GATGAG	-	-																															agacagtccttaagagaggaGatgaggacacggcaacgctc																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:61179315_61179320delGATGAG	uc001nrq.2	-	8	1308_1313	c.1174_1179delCTCATC	c.(1174-1179)CTCATCdel	p.LI392del	CPSF7_uc001nro.2_In_Frame_Del_p.LI383del|CPSF7_uc001nrp.2_In_Frame_Del_p.LI435del|CPSF7_uc001nrr.2_In_Frame_Del_p.LI383del	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	392_393					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TAAGAGAGGAGATGAGGACACGGCAA	0.524													---	---	---								-	61179320	-	-	61179315	7	5	145	1	0	1	0	1	0	0	0	0	3845	932	33	0	244	0	CPSF7	11	61179315	In_Frame_Del	DEL	GATGAG	TCGA-CR-7374-01A-11D-2012-08	995466	61179315	73827201	250	26670											
FIBP	9158	broad.mit.edu	37	chr11	65651446	65651446	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggagcgttgggaggcacctCagtcatgatacaggcgcagg	9	6	16	10	3	2	1	2	1	0	0	2	3	2	3	1	5	2	3	1	5	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:65651446C>T	uc001ogd.2	-	10	1215	c.1094G>A	c.(1093-1095)TGA>TAA	p.*365*	FIBP_uc009yqu.2_3'UTR|FIBP_uc001oge.2_Silent_p.*358*	NM_198897	NP_942600	O43427	FIBP_HUMAN	FGF intracellular binding protein isoform a	365					fibroblast growth factor receptor signaling pathway	endomembrane system|membrane|microsome|mitochondrion|nucleus	fibroblast growth factor binding			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.166)		GGAGGCACCTCAGTCATGATA	0.602											OREG0021089	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	77					0	0	0	0	T	65651446	T	T	65651446	2	4	145	1	0	0	0	0	0	0	0	1	5918	837	29	2		2	FIBP	11	65651446	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	4472131	65651446	69355070	251	26671											
NDUFV1	4723	broad.mit.edu	37	chr11	67378581	67378581	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagagaacgcaactcaggCaccaaactattcaacatctc	15	6	7	13	1	3	1	2	0	1	1	4	2	3	1	1	2	4	3	1	2	5	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:67378581C>T	uc001omj.2	+	6	969	c.816C>T	c.(814-816)GGC>GGT	p.G272G	NDUFV1_uc010rpv.1_Silent_p.G171G|NDUFV1_uc001oml.2_Silent_p.G265G|NDUFV1_uc001omk.3_Silent_p.G263G|NDUFV1_uc009yrz.1_Silent_p.G171G|NDUFV1_uc010rpw.1_5'UTR	NM_007103	NP_009034	P49821	NDUV1_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 1	272					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)	GCAACTCAGGCACCAAACTAT	0.542													42	115					0	0	0	0	T	67378581	T	T	67378581	2	4	145	1	0	0	0	0	0	0	0	1	10353	697	25	4		4	NDUFV1	11	67378581	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1727135	67378581	67627935	252	26672											
PRKRIR	5612	broad.mit.edu	37	chr11	76063227	76063227	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcctggccacgacaatactCcatatttaatccccacttct	11	11	4	15	1	1	0	0	0	1	0	3	1	3	0	5	1	2	0	5	1	4	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:76063227C>A	uc001oxh.1	-	5	967	c.967G>T	c.(967-969)GAG>TAG	p.E323*	PRKRIR_uc010rrz.1_Nonsense_Mutation_p.E148*	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	323					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						CGACAATACTCCATATTTAAT	0.383													41	86					9.55421e-19	1.57622e-18	1	0	A	76063227	A	A	76063227	4	1	145	1	0	0	0	0	0	1	0	0	12588	864	30	2	1322	2	PRKRIR	11	76063227	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	8684646	76063227	58943289	253	26673											
PCF11	51585	broad.mit.edu	37	chr11	82879779	82879779	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	accaggacaaatggggggagGaggccctttgagatttgagg	11	7	17	6	0	0	2	0	2	0	1	0	6	0	5	2	7	0	0	2	7	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:82879779G>C	uc001ozx.3	+	8	2747	c.2402G>C	c.(2401-2403)GGA>GCA	p.G801A	PCF11_uc010rsu.1_Missense_Mutation_p.G932A	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	801	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ATGGGGGGAGGAGGCCCTTTG	0.522													7	83					0	0	0	0	C	82879779	C	C	82879779	3	2	145	1	0	0	0	0	1	0	0	0	11627	1174	41	2	2432	2	PCF11	11	82879779	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	6816552	82879779	52126737	254	26674											
ME3	10873	broad.mit.edu	37	chr11	86152375	86152378	+	Frame_Shift_Del	DEL	AAAG	-	-																															caagtgtagctgtccagtgtAaaggagtcatagtctggagt																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:86152375_86152378delAAAG	uc001pbz.2	-	14	2012_2015	c.1758_1761delCTTT	c.(1756-1761)TCCTTTfs	p.S586fs	ME3_uc001pca.2_Frame_Shift_Del_p.S586fs|ME3_uc009yvk.2_Frame_Shift_Del_p.S586fs	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	586_587					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	TGTCCAGTGTAAAGGAGTCATAGT	0.51													---	---	---								-	86152378	-	-	86152375	7	5	145	1	0	1	0	1	0	0	0	0	9472	359	13	0	57	0	ME3	11	86152375	Frame_Shift_Del	DEL	AAAG	TCGA-CR-7374-01A-11D-2012-08	3272596	86152375	48854141	255	26675											
DYNC2H1	79659	broad.mit.edu	37	chr11	103027117	103027117	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggatattttgtgttaaatagGatttaaatagtcgggcacaa	14	14	10	3	1	0	0	0	0	0	0	1	2	0	2	0	3	0	2	0	3	8	8			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:103027117G>C	uc001pho.2	+	26	3889	c.3745G>C	c.(3745-3747)GAT>CAT	p.D1249H	DYNC2H1_uc001phn.1_Missense_Mutation_p.D1249H|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1249	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TGTTAAATAGGATTTAAATAG	0.284													26	45					0	0	0	0	C	103027117	C	C	103027117	3	2	145	1	0	0	0	0	1	0	0	0	4868	1188	41	2	3847	2	DYNC2H1	11	103027117	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	16874742	103027117	31979399	256	26676											
CASP1	834	broad.mit.edu	37	chr11	104904955	104904955	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgctgagagtcccagcgtcCctgccaggtaactgtcttct	6	11	10	14	1	2	1	0	1	2	1	4	2	4	1	3	1	4	2	3	1	1	2	rs2509649		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:104904955C>T	uc010rve.1	-	2	271	c.254G>A	c.(253-255)GGG>GAG	p.G85E	CASP1_uc001pig.2_Intron|CASP1_uc001pik.2_Missense_Mutation_p.G69E|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Missense_Mutation_p.G85E|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CASP1_uc001pim.3_Missense_Mutation_p.G85E|CASP1_uc009yxi.2_Missense_Mutation_p.G85E|CASP1_uc010rvj.1_Missense_Mutation_p.G85E|CASP1_uc009yxj.2_5'UTR|CASP1_uc010rvk.1_Missense_Mutation_p.G46E|CASP1_uc010rvl.1_Missense_Mutation_p.G85E	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	85	CARD.				cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TCCCAGCGTCCCTGCCAGGTA	0.468													6	270					0	0	0	0	T	104904955	T	T	104904955	3	4	145	1	0	0	0	0	1	0	0	0	2680	623	22	4	992	4	CASP1	11	104904955	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1877838	104904955	30101561	257	26677											
NPAT	4863	broad.mit.edu	37	chr11	108043717	108043717	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagtattctcttcttttacaGaagatgaaggctcctgtgaa	11	15	8	7	0	2	4	0	2	2	2	4	4	3	4	1	1	1	2	1	1	6	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:108043717G>A	uc001pjz.3	-	13	2096	c.1994C>T	c.(1993-1995)TCT>TTT	p.S665F	NPAT_uc010rvv.1_5'Flank|NPAT_uc001pka.2_Missense_Mutation_p.S460F	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	665					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TTCTTTTACAGAAGATGAAGG	0.393													5	78					0	0	0	0	A	108043717	A	A	108043717	3	1	145	1	0	0	0	0	1	0	0	0	10620	942	33	2	2313	2	NPAT	11	108043717	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3138762	108043717	26962799	258	26678											
CBL	867	broad.mit.edu	37	chr11	119144609	119144609	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttggaagagctttcgacagGctctacatgaagtgcatccc	10	10	10	11	1	1	2	0	1	1	1	3	4	2	3	1	2	3	3	1	2	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:119144609G>C	uc001pwe.2	+	4	760	c.622G>C	c.(622-624)GCT>CCT	p.A208P		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	208	Cbl-PTB.|EF-hand-like.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CTTTCGACAGGCTCTACATGA	0.458									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				24	56					0	0	0	0	C	119144609	C	C	119144609	3	2	145	1	0	0	0	0	1	0	0	0	2712	1203	42	4	636	4	CBL	11	119144609	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	11100892	119144609	15861907	259	26679											
TBCEL	219899	broad.mit.edu	37	chr11	120925915	120925915	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttatgtttccttcactggatAccctcgtcctggccaacaat	8	14	6	13	1	1	0	1	0	0	0	4	1	3	1	4	2	2	1	4	2	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:120925915A>T	uc009zay.2	+	5	688	c.610A>T	c.(610-612)ACC>TCC	p.T204S	TBCEL_uc001pxo.2_Missense_Mutation_p.T204S|TBCEL_uc001pxp.2_Missense_Mutation_p.T60S|TBCEL_uc001pxq.2_Intron	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	204	LRR 6.					cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		TTCACTGGATACCCTCGTCCT	0.418													40	63					0	0	0	0	T	120925915	T	T	120925915	3	4	145	1	0	0	0	0	1	0	0	0	15701	391	14	5	624	5	TBCEL	11	120925915	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	1781306	120925915	14080601	260	26680											
SORL1	6653	broad.mit.edu	37	chr11	121476228	121476228	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagtacaggttcagtgtctCagcaaggcacacaacaccaa	16	6	8	11	0	2	0	2	0	1	0	3	0	2	0	1	2	3	4	1	2	5	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:121476228C>G	uc001pxx.2	+	35	4976	c.4896C>G	c.(4894-4896)CTC>CTG	p.L1632L	SORL1_uc010rzp.1_Silent_p.L478L|SORL1_uc010rzq.1_Silent_p.L247L	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1632	Extracellular (Potential).|Fibronectin type-III 1.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TTCAGTGTCTCAGCAAGGCAC	0.443													29	357					0	0	0	0	G	121476228	G	G	121476228	2	3	145	1	0	0	0	0	0	0	0	1	14998	813	29	2		2	SORL1	11	121476228	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	550313	121476228	13530288	261	26681											
C12orf60	144608	broad.mit.edu	37	chr12	14976373	14976373	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagagcaatcagatgtcacCacatctgagagaaccagaag	18	5	9	9	0	3	5	2	1	1	4	3	6	3	5	2	0	2	1	2	0	4	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:14976373C>T	uc001rcj.3	+	2	708	c.504C>T	c.(502-504)ACC>ACT	p.T168T		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	168										ovary(1)|central_nervous_system(1)	2						CAGATGTCACCACATCTGAGA	0.393													6	77					0	0	0	0	T	14976373	T	T	14976373	2	4	145	1	0	0	0	0	0	0	0	1	1709	581	21	4		4	C12orf60	12	14976373	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08		14976373	118875522	262	26682											
SUOX	6821	broad.mit.edu	37	chr12	56396425	56396425	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caccttctctggtgataactCcagcacccagggatggagag	10	8	11	12	0	1	2	0	1	1	1	3	4	2	3	3	3	2	1	3	3	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:56396425C>G	uc001six.2	+	5	475	c.149C>G	c.(148-150)TCC>TGC	p.S50C	SUOX_uc009zoh.2_Missense_Mutation_p.S50C|SUOX_uc001siy.2_Missense_Mutation_p.S50C|SUOX_uc001siz.2_Missense_Mutation_p.S50C|SUOX_uc001sja.2_Missense_Mutation_p.S50C	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	50						mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			GGTGATAACTCCAGCACCCAG	0.537													39	201					0	0	0	0	G	56396425	G	G	56396425	3	3	145	1	0	0	0	0	1	0	0	0	15461	855	30	2	155	2	SUOX	12	56396425	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	41420052	56396425	77455470	263	26683											
SMARCC2	6601	broad.mit.edu	37	chr12	56572300	56572300	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgctctcccttgttccccgTactgttctcatcctcatcct	3	16	4	18	1	3	0	2	0	2	0	8	0	6	0	5	0	2	4	5	0	1	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:56572300T>C	uc001skb.2	-	14	1304	c.1198A>G	c.(1198-1200)ACG>GCG	p.T400A	SMARCC2_uc001skd.2_Missense_Mutation_p.T400A|SMARCC2_uc001ska.2_Missense_Mutation_p.T400A|SMARCC2_uc001skc.2_Missense_Mutation_p.T400A|SMARCC2_uc010sqf.1_Missense_Mutation_p.T289A	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	400					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TTGTTCCCCGTACTGTTCTCA	0.542													5	145					0	0	0	0	C	56572300	C	C	56572300	3	2	145	1	0	0	0	0	1	0	0	0	14840	1638	57	5	2603	5	SMARCC2	12	56572300	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	175875	56572300	77279595	264	26684											
MARS	4141	broad.mit.edu	37	chr12	57883081	57883081	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttatctggctgggagcaaGatgacctcactaaccagtgg	10	10	12	9	0	2	2	1	1	1	1	2	3	2	3	2	3	2	3	2	3	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:57883081G>A	uc001sog.2	+	3	255	c.232G>A	c.(232-234)GAT>AAT	p.D78N	ARHGAP9_uc001sod.2_5'Flank|ARHGAP9_uc001soe.1_5'Flank|MARS_uc001sof.1_RNA|MARS_uc010srp.1_Intron|MARS_uc010srq.1_5'UTR	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	78	GST C-terminal.				methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	CTGGGAGCAAGATGACCTCAC	0.517													11	158					0	0	0	0	A	57883081	A	A	57883081	3	1	145	1	0	0	0	0	1	0	0	0	9369	942	33	2	242	2	MARS	12	57883081	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1310781	57883081	75968814	265	26685											
NUP107	57122	broad.mit.edu	37	chr12	69109407	69109407	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acttttttttcttcttacagGaccctgatgctcccataaga	9	16	5	11	0	2	2	0	1	2	1	3	3	3	3	2	1	2	1	2	1	2	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:69109407G>T	uc001suf.2	+	12	1085	c.970G>T	c.(970-972)GAC>TAC	p.D324Y	NUP107_uc001sug.2_Missense_Mutation_p.D171Y|NUP107_uc010stj.1_Missense_Mutation_p.D295Y	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	324					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			CTTCTTACAGGACCCTGATGC	0.358													49	109					2.0833e-19	3.46894e-19	1	0	T	69109407	T	T	69109407	3	4	145	1	0	0	0	0	1	0	0	0	10807	1188	41	2	1016	2	NUP107	12	69109407	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	11226326	69109407	64742488	266	26686											
TBC1D15	64786	broad.mit.edu	37	chr12	72278770	72278770	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatagcaaactactgattGaatctcttgaaaaatatgtg	16	12	8	5	0	1	4	0	3	1	1	2	5	1	4	0	0	3	1	0	0	7	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:72278770G>T	uc001swu.2	+	5	598	c.589G>T	c.(589-591)GAA>TAA	p.E197*	TBC1D15_uc009zrv.2_Nonsense_Mutation_p.E76*|TBC1D15_uc010stt.1_Nonsense_Mutation_p.E183*|TBC1D15_uc001swv.2_Nonsense_Mutation_p.E197*|TBC1D15_uc001sww.2_Intron	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15 isoform 1	175							protein binding|Rab GTPase activator activity				0						ACTACTGATTGAATCTCTTGA	0.353													15	77					2.31682e-05	3.46314e-05	1	0	T	72278770	T	T	72278770	4	4	145	1	0	0	0	0	0	1	0	0	15670	1291	45	2	665	2	TBC1D15	12	72278770	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3169363	72278770	61573125	267	26687											
NAV3	89795	broad.mit.edu	37	chr12	78444768	78444768	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtataccacgcctctccGtcgagctgctgtctctaggc	6	11	9	15	3	2	0	0	0	2	0	5	1	2	0	3	1	3	3	3	1	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:78444768G>A	uc001syp.2	+	11	2530	c.2357G>A	c.(2356-2358)CGT>CAT	p.R786H	NAV3_uc001syo.2_Missense_Mutation_p.R786H|NAV3_uc010sub.1_Missense_Mutation_p.R286H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	786						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACGCCTCTCCGTCGAGCTGCT	0.557										HNSCC(70;0.22)			17	40					0	0	0	0	A	78444768	A	A	78444768	3	1	145	1	0	0	0	0	1	0	0	0	10238	1145	40	1	2399	1	NAV3	12	78444768	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	6165998	78444768	55407127	268	26688											
CCDC41	51134	broad.mit.edu	37	chr12	94806149	94806149	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttatgatgctcacatcgtaAcctttcatcaattaacattt	12	17	3	9	1	3	1	3	1	0	0	4	1	3	1	1	0	3	2	1	0	4	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:94806149A>T	uc001tdd.2	-	3	704	c.118T>A	c.(118-120)TTA>ATA	p.L40I	CCDC41_uc001tde.2_Missense_Mutation_p.L40I|CCDC41_uc009zsw.1_RNA|CCDC41_uc001tdf.2_Missense_Mutation_p.L40I	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	32	Potential.										0						TCACATCGTAACCTTTCATCA	0.378													32	116					0	0	0	0	T	94806149	T	T	94806149	3	4	145	1	0	0	0	0	1	0	0	0	2826	40	2	5	2047	5	CCDC41	12	94806149	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	16361381	94806149	39045746	269	26689											
NR1H4	9971	broad.mit.edu	37	chr12	100934551	100934551	+	Frame_Shift_Del	DEL	C	-	-																															agattttcaataagaaacttCcgtctgggcattctgaccta																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:100934551delC	uc001tht.1	+	7	1091	c.1063delC	c.(1063-1065)CCGfs	p.P355fs	NR1H4_uc001thp.1_Frame_Shift_Del_p.P341fs|NR1H4_uc001thq.1_Frame_Shift_Del_p.P345fs|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Frame_Shift_Del_p.P345fs|NR1H4_uc010svk.1_Frame_Shift_Del_p.P294fs|NR1H4_uc001ths.1_Frame_Shift_Del_p.P351fs	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	355	Ligand-binding.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TAAGAAACTTCCGTCTGGGCA	0.378													---	---	---								-	100934551	-	-	100934551	7	5	145	1	0	1	0	1	0	0	0	0	10673	855	30	0	1047	0	NR1H4	12	100934551	Frame_Shift_Del	DEL	C	TCGA-CR-7374-01A-11D-2012-08	6128402	100934551	32917344	270	26690											
UTP20	27340	broad.mit.edu	37	chr12	101750774	101750774	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagacattgcacgcagcactCttgcgaaaataatagaggat	15	8	10	8	2	1	2	0	0	1	2	1	5	1	3	0	1	3	3	0	1	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:101750774C>G	uc001tia.1	+	43	5761	c.5605C>G	c.(5605-5607)CTT>GTT	p.L1869V		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1869	HEAT 2.				endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						ACGCAGCACTCTTGCGAAAAT	0.388													28	48					0	0	0	0	G	101750774	G	G	101750774	3	3	145	1	0	0	0	0	1	0	0	0	17167	913	32	2	5775	2	UTP20	12	101750774	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	816223	101750774	32101121	271	26691											
RFX4	5992	broad.mit.edu	37	chr12	107109319	107109319	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaccggaaactcatcaccCaatgtaagctgtcccaccag	13	6	7	15	1	2	0	2	0	0	0	3	1	3	1	4	1	3	3	4	1	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:107109319C>T	uc001tlr.2	+	11	1201	c.1135C>T	c.(1135-1137)CAA>TAA	p.Q379*	RFX4_uc010swv.1_RNA|RFX4_uc001tls.2_Nonsense_Mutation_p.Q388*|RFX4_uc001tlt.2_Nonsense_Mutation_p.Q388*|RFX4_uc001tlv.2_Nonsense_Mutation_p.Q285*	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	379	Necessary for dimerization.				transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						ACTCATCACCCAATGTAAGCT	0.458													49	96					0	0	0	0	T	107109319	T	T	107109319	4	4	145	1	0	0	0	0	0	1	0	0	13330	595	21	4	1350	4	RFX4	12	107109319	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	5358545	107109319	26742576	272	26692											
KCTD10	83892	broad.mit.edu	37	chr12	109893929	109893929	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgaggctcttaccttggtCtgtttcttctcagtggcata	5	16	9	11	1	4	0	1	0	4	0	6	1	4	0	1	3	1	3	1	3	2	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:109893929C>A	uc001toi.1	-	6	805	c.717G>T	c.(715-717)CAG>CAT	p.Q239H	KCTD10_uc001toh.1_RNA|KCTD10_uc009zvi.1_Missense_Mutation_p.Q213H|KCTD10_uc001toj.1_Missense_Mutation_p.Q248H|KCTD10_uc001tok.1_Missense_Mutation_p.Q58H	NM_031954	NP_114160	Q9H3F6	BACD3_HUMAN	potassium channel tetramerisation domain	239	PCNA-binding (By similarity).				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|nucleus|voltage-gated potassium channel complex	voltage-gated potassium channel activity				0						TTACCTTGGTCTGTTTCTTCT	0.473													25	62					4.7796e-09	7.37542e-09	1	0	A	109893929	A	A	109893929	3	1	145	1	0	0	0	0	1	0	0	0	8136	912	32	2	232	2	KCTD10	12	109893929	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2784610	109893929	23957966	273	26693											
C12orf51	283450	broad.mit.edu	37	chr12	112711557	112711557	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgatcgatatagtcatttGagcatgtccatagcatgttg	11	14	9	7	1	1	2	1	2	0	0	3	3	2	2	1	0	2	3	1	0	3	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:112711557G>C	uc009zwc.2	-	4	566	c.548C>G	c.(547-549)TCA>TGA	p.S183*	C12orf51_uc010syk.1_Nonsense_Mutation_p.S6*|C12orf51_uc001tts.2_Nonsense_Mutation_p.S6*|C12orf51_uc001ttt.3_Nonsense_Mutation_p.S6*	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						ATAGTCATTTGAGCATGTCCA	0.443													9	167					0	0	0	0	C	112711557	C	C	112711557	4	2	145	1	0	0	0	0	0	1	0	0	1702	1294	45	2	11706	2	C12orf51	12	112711557	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2817628	112711557	21140338	274	26694											
HPD	3242	broad.mit.edu	37	chr12	122281718	122281718	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagataagaactccaggccTctctctctcaagtggcgaat	12	9	8	12	1	3	2	1	0	2	2	6	3	4	2	2	2	1	0	2	2	4	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:122281718T>C	uc001ubj.2	-	12	892	c.852A>G	c.(850-852)AGA>AGG	p.R284R	HPD_uc001ubk.2_Silent_p.R245R	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	284					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	ACTCCAGGCCTCTCTCTCTCA	0.537													3	93					0	0	0	0	C	122281718	C	C	122281718	2	2	145	1	0	0	0	0	0	0	0	1	7371	1548	54	5		5	HPD	12	122281718	Silent	SNP	T	TCGA-CR-7374-01A-11D-2012-08	9570161	122281718	11570177	275	26695											
MPHOSPH9	10198	broad.mit.edu	37	chr12	123651318	123651318	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccatttccgcctgctgacGtctgaagttgctagtgtgct	6	13	11	11	2	1	2	0	2	1	0	2	2	2	2	3	0	4	4	3	0	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:123651318G>A	uc001uel.2	-	13	2126	c.2019C>T	c.(2017-2019)GAC>GAT	p.D673D	MPHOSPH9_uc010tal.1_Silent_p.D127D|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Silent_p.D127D	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	673					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		GCCTGCTGACGTCTGAAGTTG	0.473													73	146					0	0	0	0	A	123651318	A	A	123651318	2	1	145	1	0	0	0	0	0	0	0	1	9781	1136	40	1		1	MPHOSPH9	12	123651318	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1369600	123651318	10200577	276	26696											
DNAH10	196385	broad.mit.edu	37	chr12	124408924	124408924	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttatcagaaatgttttcagAcaactttgggcaacttcctg	11	15	7	8	0	2	2	2	0	0	2	3	2	3	2	1	1	2	2	1	1	4	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:124408924A>G	uc001uft.3	+	66	11382	c.11357A>G	c.(11356-11358)GAC>GGC	p.D3786G	DNAH10_uc001ufu.3_5'Flank	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3786					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATGTTTTCAGACAACTTTGGG	0.453													14	38					0	0	0	0	G	124408924	G	G	124408924	3	3	145	1	0	0	0	0	1	0	0	0	4620	275	10	5	11619	5	DNAH10	12	124408924	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	757606	124408924	9442971	277	26697											
UBC	7316	broad.mit.edu	37	chr12	125397588	125397588	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgtcactgggctcgacctCaagggtgatggtcttgccag	7	10	14	10	1	3	1	2	1	1	0	4	2	3	1	2	3	1	1	2	3	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:125397588C>G	uc001ugs.3	-	2	1178	c.730G>C	c.(730-732)GAG>CAG	p.E244Q	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.E244Q|UBC_uc001ugt.2_Missense_Mutation_p.E244Q|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Missense_Mutation_p.E92Q	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	244	Ubiquitin-like 4.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GGCTCGACCTCAAGGGTGATG	0.512													21	330					0	0	0	0	G	125397588	G	G	125397588	3	3	145	1	0	0	0	0	1	0	0	0	16910	835	29	2	1331	2	UBC	12	125397588	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	988664	125397588	8454307	278	26698											
ATP12A	479	broad.mit.edu	37	chr13	25263504	25263504	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtccagcttcaataagatGatccctcaggtgagtggcag	11	10	11	9	0	2	3	2	2	0	1	4	3	4	3	2	2	1	2	2	2	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:25263504G>C	uc001upp.2	+	5	724	c.537G>C	c.(535-537)ATG>ATC	p.M179I	ATP12A_uc010aaa.2_Missense_Mutation_p.M179I	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	179	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TCAATAAGATGATCCCTCAGG	0.552													20	124					0	0	0	0	C	25263504	C	C	25263504	3	2	145	1	0	0	0	0	1	0	0	0	1124	1290	45	2	555	2	ATP12A	13	25263504	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08		25263504	89906374	279	26699											
MTUS2	23281	broad.mit.edu	37	chr13	29599738	29599738	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtaaactggaagcacaattAggtcagggaaagggagaggc	16	5	15	5	0	1	1	1	0	0	1	1	4	1	3	0	5	2	2	0	5	6	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:29599738A>T	uc001usl.3	+	1	991	c.933A>T	c.(931-933)TTA>TTT	p.L311F		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	301						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						AAGCACAATTAGGTCAGGGAA	0.517													19	24					0	0	0	0	T	29599738	T	T	29599738	3	4	145	1	0	0	0	0	1	0	0	0	10019	417	15	5	935	5	MTUS2	13	29599738	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	4336234	29599738	85570140	280	26700											
N4BP2L2	10443	broad.mit.edu	37	chr13	33016826	33016826	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgagattcgaaagtcaaaaaCagtttcttgtttgtaaaaga	16	13	8	4	1	2	2	1	1	1	2	3	4	2	2	0	0	1	3	0	0	5	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:33016826C>T	uc010abe.1	-	7	1870	c.1848G>A	c.(1846-1848)CTG>CTA	p.L616L	N4BP2L2_uc001uug.2_Silent_p.L499L|N4BP2L2_uc010abd.1_Silent_p.L529L|N4BP2L2_uc001uuh.2_Silent_p.L447L|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Silent_p.L601L	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		AAGTCAAAAACAGTTTCTTGT	0.323													25	30					0	0	0	0	T	33016826	T	T	33016826	2	4	145	1	0	0	0	0	0	0	0	1	10165	465	17	4		4	N4BP2L2	13	33016826	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	3417088	33016826	82153052	281	26701											
PDS5B	23047	broad.mit.edu	37	chr13	33281144	33281144	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgagggtgttccaactgatCaagccatcagagcaggtctt	11	10	11	9	0	3	3	2	2	1	1	4	3	4	3	2	2	3	2	2	2	2	2	rs141013786	by1000genomes	TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:33281144C>G	uc010abf.2	+	18	2088	c.1930C>G	c.(1930-1932)CAA>GAA	p.Q644E	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	644					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		TCCAACTGATCAAGCCATCAG	0.313													12	73					0	0	0	0	G	33281144	G	G	33281144	3	3	145	1	0	0	0	0	1	0	0	0	11746	827	29	2	1996	2	PDS5B	13	33281144	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	264318	33281144	81888734	282	26702											
STOML3	161003	broad.mit.edu	37	chr13	39564848	39564848	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttctcaggtgaagacaccCtagaatccatctcattcttg	10	12	7	12	0	3	3	2	1	3	2	6	3	4	3	2	1	0	1	2	1	3	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:39564848C>A	uc001uwx.2	-	1	149	c.11G>T	c.(10-12)AGG>ATG	p.R4M	STOML3_uc010tez.1_Translation_Start_Site	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	4						integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		TGAAGACACCCTAGAATCCAT	0.408													10	98					0.000219431	0.000323944	1	0	A	39564848	A	A	39564848	3	1	145	1	0	0	0	0	1	0	0	0	15381	681	24	4	921	4	STOML3	13	39564848	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	6283704	39564848	75605030	283	26703											
RB1	5925	broad.mit.edu	37	chr13	48955580	48955580	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatcccttgcatggctctcaGtaagtagctaaataattgaa	14	12	7	8	0	1	1	1	1	1	0	3	1	2	1	1	1	2	5	1	1	7	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:48955580G>A	uc001vcb.2	+	17	1861	c.1695_splice	c.e17+1	p.S565_splice		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(4)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATGGCTCTCAGTAAGTAGCTA	0.343		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			13	15					0	0	0	0	A	48955580	A	A	48955580	5	1	145	1	0	0	0	0	0	0	1	0	13163	1043	36	4	1762	4	RB1	13	48955580	Splice_Site	SNP	G	TCGA-CR-7374-01A-11D-2012-08	9390732	48955580	66214298	284	26704											
CYSLTR2	57105	broad.mit.edu	37	chr13	49281892	49281893	+	Missense_Mutation	DNP	GG	TT	TT																															tttgctggggagaattttaaGgacagactaaagtctgcact																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:49281892_49281893GG>TT	uc010acx.1	+	6	1622_1623	c.939_940GG>TT	c.(937-942)AAGGAC>AATTAC	p.313_314KD>NY	CYSLTR2_uc010acy.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010acz.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010ada.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010adb.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010adc.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010add.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010acw.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc001vck.2_Missense_Mutation_p.313_314KD>NY	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	313_314	Cytoplasmic (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	AGAATTTTAAGGACAGACTAAA	0.441													55	50					0	0	0	0	TT	49281893	TT	TT	49281892	3	4	145	1	0	0	0	0	1	0	0	0	4219	991	35	4	941	4	CYSLTR2	13	49281892	Missense_Mutation	DNP	GG	TCGA-CR-7374-01A-11D-2012-08	326312	49281892	65887986	285	26705											
PCCA	5095	broad.mit.edu	37	chr13	100807338	100807338	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagccattaagaaaaccaggGcccaagctgtgagtctgaat	15	7	10	9	0	1	3	0	2	1	1	1	3	1	3	3	1	3	1	3	1	6	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:100807338G>T	uc001voo.2	+	5	444	c.406G>T	c.(406-408)GCC>TCC	p.A136S	PCCA_uc010aga.2_Missense_Mutation_p.A110S|PCCA_uc010tiz.1_Missense_Mutation_p.A136S	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	136	Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	GAAAACCAGGGCCCAAGCTGT	0.423													103	52					7.34945e-47	1.37037e-46	1	0	T	100807338	T	T	100807338	3	4	145	1	0	0	0	0	1	0	0	0	11558	1203	42	4	424	4	PCCA	13	100807338	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	51525446	100807338	14362540	286	26706											
POTEG	404785	broad.mit.edu	37	chr14	19553818	19553818	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatggagccgaggtaccaCgtccgtcgagaagatctgga	10	8	13	10	4	2	2	1	0	1	2	4	6	3	4	3	3	2	1	3	3	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:19553818C>G	uc001vuz.1	+	1	454	c.402C>G	c.(400-402)CAC>CAG	p.H134Q	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	134										ovary(1)	1						CGAGGTACCACGTCCGTCGAG	0.587													21	452					0	0	0	0	G	19553818	G	G	19553818	3	3	145	1	0	0	0	0	1	0	0	0	12321	535	19	3	404	3	POTEG	14	19553818	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08		19553818	87795722	287	26707											
FOXG1	2290	broad.mit.edu	37	chr14	29237608	29237608	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaacggggagatcccgtacGccacgcaccacctcacggcc	9	4	10	18	5	2	1	2	0	0	1	3	2	3	1	5	3	2	2	5	3	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:29237608G>T	uc001wqe.2	+	1	1322	c.1123G>T	c.(1123-1125)GCC>TCC	p.A375S		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	375					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GATCCCGTACGCCACGCACCA	0.677													40	88					2.75727e-19	4.56992e-19	1	0	T	29237608	T	T	29237608	3	4	145	1	0	0	0	0	1	0	0	0	6041	1087	38	3	1125	3	FOXG1	14	29237608	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	9683790	29237608	78111932	288	26708											
FOXA1	3169	broad.mit.edu	37	chr14	38060620	38060620	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cacaccttggtagtacgccgGctccagggctgagggctcga	7	7	14	13	3	0	1	0	1	0	0	2	2	1	1	3	4	1	5	3	4	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:38060620G>A	uc001wuf.2	-	2	1681	c.1369C>T	c.(1369-1371)CCG>TCG	p.P457S	FOXA1_uc010tpz.1_Missense_Mutation_p.P424S	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	457					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TAGTACGCCGGCTCCAGGGCT	0.612													4	103					0	0	0	0	A	38060620	A	A	38060620	3	1	145	1	0	0	0	0	1	0	0	0	6021	1203	42	4	53	4	FOXA1	14	38060620	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	8823012	38060620	69288920	289	26709											
SLC35F4	341880	broad.mit.edu	37	chr14	58060786	58060786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtctactgatgccactgtGtgaactggggcagttggctc	6	13	13	9	0	1	2	0	2	1	0	2	2	1	2	1	3	3	3	1	3	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:58060786G>A	uc001xdb.1	-	2	268	c.268C>T	c.(268-270)CAC>TAC	p.H90Y	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_5'UTR	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						ATGCCACTGTGTGAACTGGGG	0.488													18	27					0	0	0	0	A	58060786	A	A	58060786	3	1	145	1	0	0	0	0	1	0	0	0	14655	1377	48	4	1325	4	SLC35F4	14	58060786	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	20000166	58060786	49288754	290	26710											
SYT16	83851	broad.mit.edu	37	chr14	62550913	62550913	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgttgttcttcccctccaGagtggagggtctccgctcag	4	14	11	12	1	3	1	1	0	2	1	6	2	5	2	4	2	0	3	4	2	0	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:62550913G>A	uc001xfu.1	+	5	1632	c.1435_splice	c.e5-1	p.S479_splice	SYT16_uc010tse.1_Splice_Site_p.S37_splice	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like											central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TTCCCCTCCAGAGTGGAGGGT	0.522													42	148					0	0	0	0	A	62550913	A	A	62550913	5	1	145	1	0	0	0	0	0	0	1	0	15538	956	33	2	1452	2	SYT16	14	62550913	Splice_Site	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4490127	62550913	44798627	291	26711											
ZBTB25	7597	broad.mit.edu	37	chr14	64954378	64954378	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgctcctccagggcctGggtggcaggacaggccctct	4	8	15	14	0	1	0	0	0	1	0	3	1	3	1	4	6	1	2	4	6	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:64954378G>A	uc001xhf.2	-	3	754	c.571C>T	c.(571-573)CAG>TAG	p.Q191*	ZBTB25_uc001xhc.2_Intron|ZBTB25_uc001xhg.2_Nonsense_Mutation_p.Q191*	NM_006977	NP_008908	P24278	ZBT25_HUMAN	zinc finger protein 46	191						cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		TCCAGGGCCTGGGTGGCAGGA	0.592													141	286					0	0	0	0	A	64954378	A	A	64954378	4	1	145	1	0	0	0	0	0	1	0	0	17599	1357	47	4	740	4	ZBTB25	14	64954378	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2403465	64954378	42395162	292	26712											
PLEKHH1	57475	broad.mit.edu	37	chr14	68029252	68029252	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggacaaagacctctgccAgggaaggtggtcctggcagc	9	6	15	11	0	1	1	0	0	1	1	2	3	2	3	3	5	2	1	3	5	2	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:68029252A>T	uc001xjl.1	+	7	1046	c.904A>T	c.(904-906)AGG>TGG	p.R302W		NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	302						cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		GACCTCTGCCAGGGAAGGTGG	0.592													15	49					0	0	0	0	T	68029252	T	T	68029252	3	4	145	1	0	0	0	0	1	0	0	0	12131	179	7	5	926	5	PLEKHH1	14	68029252	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	3074874	68029252	39320288	293	26713											
SLC39A9	55334	broad.mit.edu	37	chr14	69919976	69919976	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatccagaagcagcaaggtCtagcaattccaaaatcacca	17	6	7	11	0	2	2	1	0	1	2	4	2	4	2	3	1	3	3	3	1	6	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:69919976C>G	uc001xle.2	+	4	1102	c.422C>G	c.(421-423)TCT>TGT	p.S141C	SLC39A9_uc010aqx.2_Intron|SLC39A9_uc001xlf.3_Missense_Mutation_p.S141C|SLC39A9_uc001xlg.3_RNA	NM_018375	NP_060845	Q9NUM3	S39A9_HUMAN	solute carrier family 39 (zinc transporter),	141					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		GCAGCAAGGTCTAGCAATTCC	0.448													7	199					0	0	0	0	G	69919976	G	G	69919976	3	3	145	1	0	0	0	0	1	0	0	0	14689	913	32	2	436	2	SLC39A9	14	69919976	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1890724	69919976	37429564	294	26714											
SFRS5	6430	broad.mit.edu	37	chr14	70238141	70238141	+	Frame_Shift_Del	DEL	C	-	-																															ggatcgccagaggtcccggtCccgatcaaggtccagatcag																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:70238141delC	uc001xll.2	+	9	2233	c.782delC	c.(781-783)TCCfs	p.S261fs	SFRS5_uc001xlm.2_RNA|SFRS5_uc001xlo.2_Frame_Shift_Del_p.S261fs|SFRS5_uc001xlp.2_Frame_Shift_Del_p.S261fs|SFRS5_uc001xlq.2_Frame_Shift_Del_p.S258fs	NM_006925	NP_008856	Q13243	SRSF5_HUMAN	splicing factor, arginine/serine-rich 5	261	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding				0				all cancers(60;0.00144)|BRCA - Breast invasive adenocarcinoma(234;0.0132)|OV - Ovarian serous cystadenocarcinoma(108;0.0154)		AGGTCCCGGTCCCGATCAAGG	0.463													---	---	---								-	70238141	-	-	70238141	7	5	145	1	0	1	0	1	0	0	0	0	14245	855	30	0	808	0	SFRS5	14	70238141	Frame_Shift_Del	DEL	C	TCGA-CR-7374-01A-11D-2012-08	318165	70238141	37111399	295	26715											
FLRT2	23768	broad.mit.edu	37	chr14	86088200	86088200	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccaagaatgtcagagttctCcatttgcaggaaaacaatat	15	10	7	9	0	2	2	1	0	1	2	3	3	2	3	2	1	2	2	2	1	6	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:86088200C>T	uc001xvr.2	+	2	1109	c.342C>T	c.(340-342)CTC>CTT	p.L114L	FLRT2_uc010atd.2_Silent_p.L114L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	114	LRR 3.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TCAGAGTTCTCCATTTGCAGG	0.493													61	133					0	0	0	0	T	86088200	T	T	86088200	2	4	145	1	0	0	0	0	0	0	0	1	5971	842	30	2		2	FLRT2	14	86088200	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	15850059	86088200	21261340	296	26716											
PTPN21	11099	broad.mit.edu	37	chr14	88983571	88983571	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacccaccggcgctgatttTgcttgttgtagtaccagagg	7	12	11	11	2	0	2	0	1	0	1	0	2	0	2	3	2	3	5	3	2	3	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:88983571T>G	uc001xwv.3	-	3	546	c.215A>C	c.(214-216)CAA>CCA	p.Q72P	PTPN21_uc010twc.1_5'UTR|PTPN21_uc010atf.1_Missense_Mutation_p.Q72P	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	72	FERM.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GCGCTGATTTTGCTTGTTGTA	0.423													50	112					0	0	0	0	G	88983571	G	G	88983571	3	3	145	1	0	0	0	0	1	0	0	0	12851	1812	63	5	3377	5	PTPN21	14	88983571	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	2895371	88983571	18365969	297	26717											
ATXN3	4287	broad.mit.edu	37	chr14	92560173	92560173	+	Frame_Shift_Del	DEL	A	-	-																															actttcaaggcattgcttatAacctgttaagaaaaatagca																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:92560173delA	uc001yac.3	-	4	306	c.237delT	c.(235-237)GTTfs	p.V79fs	ATXN3_uc010aug.2_Frame_Shift_Del_p.V64fs|ATXN3_uc001yad.3_Frame_Shift_Del_p.V24fs|ATXN3_uc010auh.2_Intron|ATXN3_uc001yae.3_Intron|ATXN3_uc010twl.1_Intron	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	79	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		CATTGCTTATAACCTGTTAAG	0.353													---	---	---								-	92560173	-	-	92560173	7	5	145	1	0	1	0	1	0	0	0	0	1215	349	13	0	880	0	ATXN3	14	92560173	Frame_Shift_Del	DEL	A	TCGA-CR-7374-01A-11D-2012-08	3576602	92560173	14789367	298	26718											
CPSF2	53981	broad.mit.edu	37	chr14	92625450	92625450	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacacaggggttattttaGaagaaggagaactaaaggat	16	9	13	3	0	0	3	0	0	0	3	0	6	0	5	0	5	1	1	0	5	7	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:92625450G>T	uc001yah.1	+	14	2182	c.1945G>T	c.(1945-1947)GAA>TAA	p.E649*		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	649					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		GGTTATTTTAGAAGAAGGAGA	0.413													31	62					6.04164e-23	1.04488e-22	1	0	T	92625450	T	T	92625450	4	4	145	1	0	0	0	0	0	1	0	0	3840	943	33	2	1991	2	CPSF2	14	92625450	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	65277	92625450	14724090	299	26719											
RCOR1	23186	broad.mit.edu	37	chr14	103188673	103188673	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggaggcagaacatggtaaaGaagagaccaatgggcccagt	15	4	15	7	0	0	3	0	0	0	3	0	5	0	4	2	4	1	2	2	4	5	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:103188673G>C	uc001ymb.2	+	11	1330	c.1330G>C	c.(1330-1332)GAA>CAA	p.E444Q		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	444					blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						ACATGGTAAAGAAGAGACCAA	0.413													21	277					0	0	0	0	C	103188673	C	C	103188673	3	2	145	1	0	0	0	0	1	0	0	0	13247	943	33	2	1372	2	RCOR1	14	103188673	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	10563223	103188673	4160867	300	26720											
OR4N4	283694	broad.mit.edu	37	chr15	22332412	22332413	+	Translation_Start_Site	INS	-	A	A																															ttgatattcttggcttgatgINSaaaaaaaacaagattctaac																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:22332412_22332413insA	uc001yuc.1	+	3	219_220	c.-762_-761insA	c.(-764--759)ATGAAA>ATGAAAA		LOC727924_uc001ytz.1_Intron|LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTGGCTTGATGAAAAAAAACAA	0.287													---	---	---								A	22332413	A	A	22332412	6	5	145	1	0	1	1	0	0	0	0	0	11132	1305	45	0		0	OR4N4	15	22332412	Translation_Start_Site	INS	-	TCGA-CR-7374-01A-11D-2012-08		22332412	80198980	301	26721											
OR4N4	283694	broad.mit.edu	37	chr15	22332526	22332526	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttacattgctattgtcCtgggaaacctcttgatagtg	8	18	8	7	0	1	1	0	1	1	0	2	2	2	2	2	1	3	1	2	1	4	8			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:22332526C>A	uc001yuc.1	+	3	333	c.-648C>A	c.(-650--646)TCCTG>TCATG		LOC727924_uc001ytz.1_Intron|LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGCTATTGTCCTGGGAAACCT	0.388													89	768					4.92795e-40	9.07047e-40	1	0	A	22332526	A	A	22332526	1	1	145	1	0	0	0	0	0	0	0	0	11132	696	24	4		4	OR4N4	15	22332526	Translation_Start_Site	SNP	C	TCGA-CR-7374-01A-11D-2012-08	114	22332526	80198866	302	26722											
GJD2	57369	broad.mit.edu	37	chr15	35045073	35045073	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgggagatgccttcctgcCttctgagcttggattttgat	6	14	12	9	1	1	3	0	2	1	1	2	5	2	4	3	2	4	1	3	2	0	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:35045073C>A	uc001zis.1	-	2	572	c.572G>T	c.(571-573)AGG>ATG	p.R191M	uc001zit.1_5'Flank	NM_020660	NP_065711	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	191	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		GCCTTCCTGCCTTCTGAGCTT	0.478													91	142					2.06477e-34	3.74271e-34	1	0	A	35045073	A	A	35045073	3	1	145	1	0	0	0	0	1	0	0	0	6454	681	24	4	397	4	GJD2	15	35045073	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	12712547	35045073	67486319	303	26723											
BUB1B	701	broad.mit.edu	37	chr15	40462766	40462766	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctggacagagcagaactatCctcaaggtgggaaggagagt	13	6	15	7	0	1	3	1	0	0	3	2	6	2	5	1	4	2	2	1	4	4	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:40462766C>T	uc001zkx.3	+	4	480	c.268C>T	c.(268-270)CCT>TCT	p.P90S		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	90	BUB1 N-terminal.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GCAGAACTATCCTCAAGGTGG	0.373			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				10	104					0	0	0	0	T	40462766	T	T	40462766	3	4	145	1	0	0	0	0	1	0	0	0	1576	855	30	2	282	2	BUB1B	15	40462766	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	5417693	40462766	62068626	304	26724											
GANC	2595	broad.mit.edu	37	chr15	42632035	42632035	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcatccgagaagccatcaGagagcgctatggcctcctgc	10	7	10	14	2	2	2	2	0	0	2	4	4	4	2	4	1	3	1	4	1	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:42632035G>T	uc001zpi.2	+	17	2326	c.2012G>T	c.(2011-2013)AGA>ATA	p.R671I		NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	671					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GAAGCCATCAGAGAGCGCTAT	0.542													40	75					7.53189e-24	1.31533e-23	1	0	T	42632035	T	T	42632035	3	4	145	1	0	0	0	0	1	0	0	0	6269	942	33	2	2078	2	GANC	15	42632035	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2169269	42632035	59899357	305	26725											
SLC12A1	6557	broad.mit.edu	37	chr15	48577394	48577394	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagtggaggcatccgaggCttgtttaaaaaagctggcaa	14	8	13	6	1	0	0	0	0	0	0	1	3	1	1	1	4	1	5	1	4	5	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:48577394C>T	uc001zwn.3	+	21	2793	c.2577C>T	c.(2575-2577)GGC>GGT	p.G859G	SLC12A1_uc010uew.1_Silent_p.G665G|SLC12A1_uc001zwq.3_Silent_p.G630G|SLC12A1_uc001zwr.3_Silent_p.G586G	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	859	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GCATCCGAGGCTTGTTTAAAA	0.363													66	131					0	0	0	0	T	48577394	T	T	48577394	2	4	145	1	0	0	0	0	0	0	0	1	14447	784	28	4		4	SLC12A1	15	48577394	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	5945359	48577394	53953998	306	26726											
FBN1	2200	broad.mit.edu	37	chr15	48730063	48730063	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgatttctggatttgggtGatgaacactttcctccttca	8	16	9	8	0	2	3	1	3	1	0	4	4	4	4	2	2	1	0	2	2	1	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:48730063G>A	uc001zwx.1	-	51	6543	c.6215C>T	c.(6214-6216)TCA>TTA	p.S2072L	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2072	TB 8.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GGATTTGGGTGATGAACACTT	0.502													14	167					0	0	0	0	A	48730063	A	A	48730063	3	1	145	1	0	0	0	0	1	0	0	0	5734	1294	45	2	2464	2	FBN1	15	48730063	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	152669	48730063	53801329	307	26727											
USP8	9101	broad.mit.edu	37	chr15	50773685	50773685	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttgttgctctagattgatcGtactaaaaaaccagcagtca	13	13	7	8	1	2	2	1	1	1	1	3	2	2	2	1	0	4	4	1	0	5	6	rs114434131	by1000genomes	TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:50773685G>T	uc001zym.3	+	12	1726	c.1226G>T	c.(1225-1227)CGT>CTT	p.R409L	USP8_uc001zyk.1_Missense_Mutation_p.R110L|USP8_uc001zyl.3_Missense_Mutation_p.R409L|USP8_uc001zyn.3_Missense_Mutation_p.R409L|USP8_uc010ufh.1_Missense_Mutation_p.R332L|USP8_uc010bev.1_Missense_Mutation_p.R38L	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	409	SH3-binding (By similarity).				cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TAGATTGATCGTACTAAAAAA	0.358													15	25					1.52009e-12	2.42943e-12	1	0	T	50773685	T	T	50773685	3	4	145	1	0	0	0	0	1	0	0	0	17157	1145	40	3	1264	3	USP8	15	50773685	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2043622	50773685	51757707	308	26728											
TRPM7	54822	broad.mit.edu	37	chr15	50902065	50902065	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcatccattgtcatctgatGagcatcttgagattgtggga	9	14	11	7	0	4	3	2	3	2	1	5	5	5	4	1	1	1	1	1	1	0	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:50902065G>A	uc001zyt.3	-	18	2638	c.2374C>T	c.(2374-2376)CAT>TAT	p.H792Y	TRPM7_uc010bew.1_Missense_Mutation_p.H792Y|TRPM7_uc001zyu.2_Missense_Mutation_p.H350Y	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	792	Extracellular (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		GTCATCTGATGAGCATCTTGA	0.358													35	88					0	0	0	0	A	50902065	A	A	50902065	3	1	145	1	0	0	0	0	1	0	0	0	16658	1290	45	2	3311	2	TRPM7	15	50902065	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	128380	50902065	51629327	309	26729											
PRTG	283659	broad.mit.edu	37	chr15	55929374	55929374	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttatgatatttaccttcacGgtgtaagacctgccactctc	9	15	6	11	1	2	2	1	1	1	1	3	2	2	2	3	1	2	1	3	1	4	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:55929374G>T	uc002adg.2	-	15	2665	c.2617C>A	c.(2617-2619)CGT>AGT	p.R873S		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	873	Fibronectin type-III 5.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TTACCTTCACGGTGTAAGACC	0.393													53	109					5.13769e-22	8.80044e-22	1	0	T	55929374	T	T	55929374	3	4	145	1	0	0	0	0	1	0	0	0	12700	1116	39	3	859	3	PRTG	15	55929374	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	5027309	55929374	46602018	310	26730											
FAM63B	54629	broad.mit.edu	37	chr15	59146757	59146757	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acgtaaacggaaggaaccacGagaaaaagataaagaaaaag	24	2	10	5	3	0	3	0	0	0	3	0	6	0	5	1	2	2	1	1	2	10	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:59146757G>C	uc002afj.2	+	9	2016	c.1814G>C	c.(1813-1815)CGA>CCA	p.R605P	FAM63B_uc002afi.2_Missense_Mutation_p.R604P|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_RNA	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	hypothetical protein LOC54629 isoform a	605										central_nervous_system(1)	1						AAGGAACCACGAGAAAAAGAT	0.383													12	67					0	0	0	0	C	59146757	C	C	59146757	3	2	145	1	0	0	0	0	1	0	0	0	5629	1058	37	3	1848	3	FAM63B	15	59146757	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3217383	59146757	43384635	311	26731											
GTF2A2	2958	broad.mit.edu	37	chr15	59934436	59934436	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaagtccacacattatcgCagaatctgtacgtatttaga	15	11	6	9	2	1	2	0	0	1	2	3	2	2	2	1	0	1	3	1	0	7	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:59934436C>A	uc002agg.2	-	4	385	c.203G>T	c.(202-204)TGC>TTC	p.C68F		NM_004492	NP_004483	P52657	T2AG_HUMAN	general transcription factor IIA, 2, 12kDa	68					interspecies interaction between organisms|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIA complex	protein heterodimerization activity|protein homodimerization activity|TBP-class protein binding|transcription coactivator activity			central_nervous_system(2)	2						CACATTATCGCAGAATCTGTA	0.343													37	104					3.76114e-14	6.05163e-14	1	0	A	59934436	A	A	59934436	3	1	145	1	0	0	0	0	1	0	0	0	6893	710	25	4	134	4	GTF2A2	15	59934436	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	787679	59934436	42596956	312	26732											
MAP2K1	5604	broad.mit.edu	37	chr15	66777514	66777514	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacccaggccaaggacccccGggaggccccttagctgtgag	8	4	13	16	1	0	1	0	1	0	0	0	3	0	3	6	4	1	1	6	4	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:66777514G>A	uc010bhq.2	+	7	1355	c.880G>A	c.(880-882)GGG>AGG	p.G294R	MAP2K1_uc010ujp.1_Missense_Mutation_p.G272R	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	294	Protein kinase.|Pro-rich.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						AAGGACCCCCGGGAGGCCCCT	0.607									Cardiofaciocutaneous_syndrome				21	79					0	0	0	0	A	66777514	A	A	66777514	3	1	145	1	0	0	0	0	1	0	0	0	9289	1116	39	1	906	1	MAP2K1	15	66777514	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	6843078	66777514	35753878	313	26733											
RASGRF1	5923	broad.mit.edu	37	chr15	79292109	79292109	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actggctaaggacatcctccGgtacttctccttgtttgggg	6	13	11	11	1	1	0	0	0	1	0	4	1	3	1	3	5	1	3	3	5	2	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:79292109G>T	uc002beq.2	-	18	3145	c.2770C>A	c.(2770-2772)CGG>AGG	p.R924R	RASGRF1_uc002bep.2_Silent_p.R908R|RASGRF1_uc010blm.1_Silent_p.R833R|RASGRF1_uc002ber.3_Silent_p.R908R|RASGRF1_uc010unh.1_Silent_p.R319R|RASGRF1_uc002beo.2_Silent_p.R140R	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	926					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GACATCCTCCGGTACTTCTCC	0.607													38	120					9.8876e-21	1.67761e-20	1	0	T	79292109	T	T	79292109	2	4	145	1	0	0	0	0	0	0	0	1	13137	1115	39	3		3	RASGRF1	15	79292109	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	12514595	79292109	23239283	314	26734											
EFTUD1	79631	broad.mit.edu	37	chr15	82523196	82523196	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tataccacattacctgatcaCccttcatgatctttttagcc	10	15	3	13	0	3	2	2	2	1	0	3	2	3	2	4	0	3	0	4	0	4	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:82523196C>A	uc002bgt.1	-	8	1017	c.848G>T	c.(847-849)GGT>GTT	p.G283V	EFTUD1_uc002bgu.1_Missense_Mutation_p.G232V	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	283					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						TACCTGATCACCCTTCATGAT	0.323													8	135					0.00307968	0.00446366	1	0	A	82523196	A	A	82523196	3	1	145	1	0	0	0	0	1	0	0	0	4982	507	18	4	2566	4	EFTUD1	15	82523196	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	3231087	82523196	20008196	315	26735											
MRPS11	64963	broad.mit.edu	37	chr15	89015921	89015921	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggaaagaaatttgaggaGatcccaattgcacacattaa	17	8	9	7	0	0	3	0	1	0	2	1	5	1	4	1	2	1	2	1	2	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:89015921G>A	uc002bml.2	+	3	511	c.246G>A	c.(244-246)GAG>GAA	p.E82E	MRPS11_uc002bmm.2_Intron|MRPS11_uc002bmn.2_Silent_p.E81E|MRPS11_uc010bnj.2_RNA	NM_022839	NP_073750	P82912	RT11_HUMAN	mitochondrial ribosomal protein S11 isoform a	82					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0	Lung NSC(78;0.203)		BRCA - Breast invasive adenocarcinoma(143;0.188)			AATTTGAGGAGATCCCAATTG	0.443													4	56					0	0	0	0	A	89015921	A	A	89015921	2	1	145	1	0	0	0	0	0	0	0	1	9875	933	33	2		2	MRPS11	15	89015921	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	6492725	89015921	13515471	316	26736											
MFGE8	4240	broad.mit.edu	37	chr15	89453073	89453073	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taaggcacgtgcaggtgtacGaggggaagacatctcctcgc	10	7	14	10	3	1	1	0	0	1	1	3	3	1	2	1	4	2	3	1	4	3	2	rs145851768		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:89453073G>A	uc002bng.3	-	2	268	c.155C>T	c.(154-156)TCG>TTG	p.S52L	MFGE8_uc002bnf.3_5'UTR|MFGE8_uc002bnh.3_Missense_Mutation_p.S52L|MFGE8_uc010bnn.2_Missense_Mutation_p.S44L|MFGE8_uc010upq.1_Intron|MFGE8_uc010upr.1_Missense_Mutation_p.S52L|MFGE8_uc010bno.2_Intron	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	52	EGF-like.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					GCAGGTGTACGAGGGGAAGAC	0.542													38	225					0	0	0	0	A	89453073	A	A	89453073	3	1	145	1	0	0	0	0	1	0	0	0	9573	1059	37	1	1036	1	MFGE8	15	89453073	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	437152	89453073	13078319	317	26737											
FANCI	55215	broad.mit.edu	37	chr15	89837176	89837176	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatggccaacaagacaagtGatagtcttttgtccatgaaa	16	10	8	7	0	1	3	0	2	1	1	2	3	2	3	2	1	1	0	2	1	6	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:89837176G>A	uc010bnp.1	+	23	2494	c.2404G>A	c.(2404-2406)GAT>AAT	p.D802N	FANCI_uc002bnm.1_Missense_Mutation_p.D802N|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.D623N|FANCI_uc002bnq.1_Missense_Mutation_p.D215N	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	802					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					CAAGACAAGTGATAGTCTTTT	0.398								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				27	139					0	0	0	0	A	89837176	A	A	89837176	3	1	145	1	0	0	0	0	1	0	0	0	5701	1290	45	2	2490	2	FANCI	15	89837176	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	384103	89837176	12694216	318	26738											
POLG	5428	broad.mit.edu	37	chr15	89862533	89862533	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccctcagtcctgtccactggGaggttcaactccctcaccag	7	9	8	17	0	3	0	3	0	0	0	6	1	6	1	5	2	1	1	5	2	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:89862533G>A	uc002bns.3	-	19	3312	c.3030C>T	c.(3028-3030)CTC>CTT	p.L1010L	POLG_uc002bnr.3_Silent_p.L1010L	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	1010					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			TGTCCACTGGGAGGTTCAACT	0.557								DNA_polymerases_(catalytic_subunits)					4	73					0	0	0	0	A	89862533	A	A	89862533	2	1	145	1	0	0	0	0	0	0	0	1	12255	1161	41	2		2	POLG	15	89862533	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	25357	89862533	12668859	319	26739											
FES	2242	broad.mit.edu	37	chr15	91436009	91436009	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcggtgaagtcttgtcgaGagacgctcccacctgacctc	7	9	12	13	3	1	3	0	2	1	1	4	5	2	3	3	2	0	1	3	2	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:91436009G>C	uc002bpv.2	+	14	1876	c.1780G>C	c.(1780-1782)GAG>CAG	p.E594Q	FES_uc010uqj.1_Missense_Mutation_p.E466Q|FES_uc010uqk.1_Missense_Mutation_p.E576Q|FES_uc002bpw.2_RNA|FES_uc010bny.2_Missense_Mutation_p.E466Q|FES_uc002bpx.2_Missense_Mutation_p.E524Q|FES_uc002bpy.2_Missense_Mutation_p.E536Q	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	594	Protein kinase.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GTCTTGTCGAGAGACGCTCCC	0.572													8	125					0	0	0	0	C	91436009	C	C	91436009	3	2	145	1	0	0	0	0	1	0	0	0	5852	943	33	2	1830	2	FES	15	91436009	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1573476	91436009	11095383	320	26740											
MCTP2	55784	broad.mit.edu	37	chr15	94928705	94928705	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gacagtgtttgatgaagatgGagataaacccccagattttc	13	11	10	7	0	0	5	0	2	0	3	1	7	0	5	2	1	1	1	2	1	3	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:94928705G>T	uc002btj.2	+	13	1804	c.1739G>T	c.(1738-1740)GGA>GTA	p.G580V	MCTP2_uc002bti.2_Missense_Mutation_p.G580V|MCTP2_uc010boj.2_Missense_Mutation_p.G309V|MCTP2_uc010bok.2_Missense_Mutation_p.G580V|MCTP2_uc002btk.3_Missense_Mutation_p.G168V|MCTP2_uc002btl.2_Missense_Mutation_p.G168V	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	580	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GATGAAGATGGAGATAAACCC	0.338													74	263					7.09011e-46	1.31858e-45	1	0	T	94928705	T	T	94928705	3	4	145	1	0	0	0	0	1	0	0	0	9454	1174	41	2	1789	2	MCTP2	15	94928705	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3492696	94928705	7602687	321	26741											
HBM	3042	broad.mit.edu	37	chr16	216015	216015	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccatgctcagcgcccaggagCgcgcccaaatcgcgcaggtc	8	4	12	17	5	1	0	1	0	0	0	3	1	1	1	3	2	3	2	3	2	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:216015C>A	uc002cfu.1	+	1	43	c.19C>A	c.(19-21)CGC>AGC	p.R7S		NM_001003938	NP_001003938	Q6B0K9	HBM_HUMAN	hemoglobin mu chain	7						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		all_cancers(16;1.62e-06)|all_epithelial(16;4.01e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				CGCCCAGGAGCGCGCCCAAAT	0.721													9	21					0.000442599	0.000649388	1	0	A	216015	A	A	216015	3	1	145	1	0	0	0	0	1	0	0	0	7023	768	27	3	21	3	HBM	16	216015	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08		216015	90138738	322	26742											
ACSM5	54988	broad.mit.edu	37	chr16	20439173	20439173	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccatctttcggctgcttgtgCaggaggatctgaccaggtac	7	11	12	11	1	2	1	0	1	2	0	3	3	2	3	2	4	3	4	2	4	1	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:20439173C>T	uc002dhe.2	+	7	1132	c.985C>T	c.(985-987)CAG>TAG	p.Q329*		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	329					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						GCTGCTTGTGCAGGAGGATCT	0.463													6	231					0	0	0	0	T	20439173	T	T	20439173	4	4	145	1	0	0	0	0	0	1	0	0	187	711	25	4	1007	4	ACSM5	16	20439173	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	20223158	20439173	69915580	323	26743											
ACSM2A	123876	broad.mit.edu	37	chr16	20476886	20476886	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggtgggtgaatgggaaGgggaaggaattaatgtggaa	12	9	19	1	0	0	1	0	1	0	0	0	5	0	5	0	7	0	0	0	7	6	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:20476886G>A	uc010bwe.2	+	4	464	c.225G>A	c.(223-225)AAG>AAA	p.K75K	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_5'UTR|ACSM2A_uc002dhf.3_Silent_p.K75K|ACSM2A_uc002dhg.3_Silent_p.K75K|ACSM2A_uc010vay.1_5'UTR	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	75					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						TGAATGGGAAGGGGAAGGAAT	0.572													6	72					0	0	0	0	A	20476886	A	A	20476886	2	1	145	1	0	0	0	0	0	0	0	1	183	991	35	4		4	ACSM2A	16	20476886	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	37713	20476886	69877867	324	26744											
ACSM2B	348158	broad.mit.edu	37	chr16	20570722	20570722	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccacattaattccttcccCttcccattcacccaccacag	9	12	1	19	0	1	0	1	0	0	0	5	0	5	0	7	0	0	0	7	0	1	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:20570722C>T	uc002dhj.3	-	4	435	c.225G>A	c.(223-225)AAG>AAA	p.K75K	ACSM2B_uc002dhk.3_Silent_p.K75K|ACSM2B_uc010bwf.1_Silent_p.K75K	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	75					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						ATTCCTTCCCCTTCCCATTCA	0.557													18	31					0	0	0	0	T	20570722	T	T	20570722	2	4	145	1	0	0	0	0	0	0	0	1	184	680	24	4		4	ACSM2B	16	20570722	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	93836	20570722	69784031	325	26745											
ZP2	7783	broad.mit.edu	37	chr16	21215680	21215680	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caccttctgtccaggagataTaaatgtaagcttcagagaca	14	10	8	9	0	2	2	1	0	1	2	3	4	3	2	2	1	1	2	2	1	4	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:21215680T>C	uc002dii.2	-	8	739	c.739A>G	c.(739-741)ATA>GTA	p.I247V	ZP2_uc010bwn.1_Missense_Mutation_p.I286V|ZP2_uc010bwo.2_Missense_Mutation_p.I286V	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	247	Extracellular (Potential).				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		CCAGGAGATATAAATGTAAGC	0.428													32	40					0	0	0	0	C	21215680	C	C	21215680	3	2	145	1	0	0	0	0	1	0	0	0	18283	1406	49	5	1546	5	ZP2	16	21215680	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	644958	21215680	69139073	326	26746											
ARHGAP17	55114	broad.mit.edu	37	chr16	24958893	24958893	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catcgctggtctgagcaagcTttgcaaggaacttgatcaaa	12	10	10	9	1	2	2	1	2	1	0	3	3	2	3	0	2	4	4	0	2	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:24958893T>C	uc002dnb.2	-	14	1244	c.1151A>G	c.(1150-1152)AAG>AGG	p.K384R	ARHGAP17_uc002dna.2_Missense_Mutation_p.K111R|ARHGAP17_uc002dnc.2_Missense_Mutation_p.K384R|ARHGAP17_uc010vcf.1_Missense_Mutation_p.K205R	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	384	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CTGAGCAAGCTTTGCAAGGAA	0.463													3	71					0	0	0	0	C	24958893	C	C	24958893	3	2	145	1	0	0	0	0	1	0	0	0	867	1609	56	5	1522	5	ARHGAP17	16	24958893	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	3743213	24958893	65395860	327	26747											
SEPHS2	22928	broad.mit.edu	37	chr16	30456514	30456514	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcactcatactctggctgaCgctgagtaacatcaacatgt	11	11	7	12	1	4	2	3	2	1	0	4	2	4	2	0	1	3	3	0	1	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:30456514C>A	uc010ves.1	-	2	711	c.535G>T	c.(535-537)GTC>TTC	p.V179F	SEPHS2_uc002dyh.1_Missense_Mutation_p.V122F|SEPHS2_uc010vet.1_Missense_Mutation_p.V61F	NM_012248	NP_036380	Q99611	SPS2_HUMAN	selenophosphate synthetase 2	179					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(2)	2						CTCTGGCTGACGCTGAGTAAC	0.547													62	75					2.73361e-28	4.82086e-28	1	0	A	30456514	A	A	30456514	3	1	145	1	0	0	0	0	1	0	0	0	14120	536	19	3	815	3	SEPHS2	16	30456514	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	5497621	30456514	59898239	328	26748											
ITGAL	3683	broad.mit.edu	37	chr16	30495265	30495265	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatgcggccaaagacatcatCcgctacatcatcggggtagg	11	7	12	11	3	2	1	2	0	0	1	4	2	3	1	2	4	2	2	2	4	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:30495265C>T	uc002dyi.3	+	8	1016	c.840C>T	c.(838-840)ATC>ATT	p.I280I	ITGAL_uc010veu.1_RNA|ITGAL_uc002dyj.3_Silent_p.I197I|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	280	VWFA.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	AAGACATCATCCGCTACATCA	0.582													5	249					0	0	0	0	T	30495265	T	T	30495265	2	4	145	1	0	0	0	0	0	0	0	1	7925	845	30	2		2	ITGAL	16	30495265	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	38751	30495265	59859488	329	26749											
RNF40	9810	broad.mit.edu	37	chr16	30779633	30779633	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagctggtcccctctgaagaGgacttccagggtataacccc	9	8	11	13	0	1	2	0	1	1	1	3	4	3	3	5	3	2	2	5	3	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:30779633G>A	uc002dzq.2	+	13	1884	c.1761G>A	c.(1759-1761)GAG>GAA	p.E587E	RNF40_uc010caa.2_Silent_p.E587E|RNF40_uc010cab.2_Silent_p.E487E|RNF40_uc010vfa.1_5'UTR|RNF40_uc002dzr.2_Silent_p.E587E|RNF40_uc010vfb.1_Silent_p.E279E|RNF40_uc010vfc.1_5'UTR	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	587					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			CCTCTGAAGAGGACTTCCAGG	0.622													15	28					0	0	0	0	A	30779633	A	A	30779633	2	1	145	1	0	0	0	0	0	0	0	1	13558	991	35	4		4	RNF40	16	30779633	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	284368	30779633	59575120	330	26750											
C16orf57	79650	broad.mit.edu	37	chr16	58043902	58043902	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcccagacatatgtcccccGgctggtaaggatgaaggtgt	9	9	13	10	1	0	2	0	1	0	1	1	3	1	3	3	4	1	2	3	4	3	2	rs142683238	byFrequency	TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:58043902G>A	uc002emz.2	+	3	418	c.335G>A	c.(334-336)CGG>CAG	p.R112Q	C16orf57_uc010via.1_Missense_Mutation_p.R112Q|C16orf57_uc002emy.2_RNA|C16orf57_uc010vib.1_Missense_Mutation_p.R112Q|C16orf57_uc010vic.1_Missense_Mutation_p.R61Q	NM_024598	NP_078874	Q9BQ65	CP057_HUMAN	hypothetical protein LOC79650	112											0						TATGTCCCCCGGCTGGTAAGG	0.592													9	260					0	0	0	0	A	58043902	A	A	58043902	3	1	145	1	0	0	0	0	1	0	0	0	1827	1116	39	1	345	1	C16orf57	16	58043902	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	27264269	58043902	32310851	331	26751											
CA7	766	broad.mit.edu	37	chr16	66881111	66881111	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtccaggtagacttcaaTgacagcgatgaccgaaccgg	11	8	11	11	3	2	3	1	2	1	1	3	5	3	3	3	2	2	1	3	2	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:66881111T>C	uc002eqi.2	+	2	328	c.219T>C	c.(217-219)AAT>AAC	p.N73N	uc002eqh.2_Intron|CA7_uc002eqj.2_Silent_p.N17N	NM_005182	NP_005173	P43166	CAH7_HUMAN	carbonic anhydrase VII isoform 1	73					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		TAGACTTCAATGACAGCGATG	0.582													23	46					0	0	0	0	C	66881111	C	C	66881111	2	2	145	1	0	0	0	0	0	0	0	1	2534	1461	51	5		5	CA7	16	66881111	Silent	SNP	T	TCGA-CR-7374-01A-11D-2012-08	8837209	66881111	23473642	332	26752											
PARD6A	50855	broad.mit.edu	37	chr16	67694944	67694944	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcccgcccggccccgccatGgcccggccgcagaggactcc	4	2	14	21	5	0	1	0	0	0	1	1	2	1	2	8	5	0	1	8	5	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:67694944G>C	uc002ett.2	+	1	94	c.3G>C	c.(1-3)ATG>ATC	p.M1I	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|PARD6A_uc002ets.2_Missense_Mutation_p.M1I|PARD6A_uc002etu.2_5'Flank	NM_016948	NP_058644	Q9NPB6	PAR6A_HUMAN	par-6 partitioning defective 6 homolog alpha	1	Interaction with PRKCI and PRKCZ.				cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		gccccgccATGGCCCGGCCGC	0.363													23	47					0	0	0	0	C	67694944	C	C	67694944	3	2	145	1	0	0	0	0	1	0	0	0	11499	1348	47	4	5	4	PARD6A	16	67694944	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	813833	67694944	22659809	333	26753											
EDC4	23644	broad.mit.edu	37	chr16	67913615	67913615	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcctcagtctgagcagtGagaccaagcccaagttgatg	11	9	10	11	0	2	3	1	3	1	1	3	4	3	3	3	0	2	2	3	0	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:67913615G>T	uc002eur.2	+	15	1925	c.1759G>T	c.(1759-1761)GAG>TAG	p.E587*	EDC4_uc010cer.2_Nonsense_Mutation_p.E206*|EDC4_uc010vkg.1_Nonsense_Mutation_p.E519*|EDC4_uc010ces.1_Nonsense_Mutation_p.E375*|EDC4_uc002eus.2_Nonsense_Mutation_p.E317*|EDC4_uc002eut.1_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	587					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TCTGAGCAGTGAGACCAAGCC	0.632													7	231					0.000274275	0.000403246	1	0	T	67913615	T	T	67913615	4	4	145	1	0	0	0	0	0	1	0	0	4930	1291	45	2	1817	2	EDC4	16	67913615	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	218671	67913615	22441138	334	26754											
SLC7A6OS	84138	broad.mit.edu	37	chr16	68337973	68337973	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcacggagaggatgttctCaatccagcctggagtggccg	8	8	14	11	2	1	1	1	0	1	1	3	4	2	3	3	4	2	2	3	4	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:68337973C>G	uc002evw.1	-	3	653	c.634G>C	c.(634-636)GAG>CAG	p.E212Q		NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	212					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		AGGATGTTCTCAATCCAGCCT	0.527													10	145					0	0	0	0	G	68337973	G	G	68337973	3	3	145	1	0	0	0	0	1	0	0	0	14766	835	29	2	307	2	SLC7A6OS	16	68337973	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	424358	68337973	22016780	335	26755											
CDH3	1001	broad.mit.edu	37	chr16	68729192	68729192	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcttttgttggtgagaaaGaagcggaagatcaaggagcc	12	9	14	6	1	1	3	1	1	0	3	1	6	1	5	1	3	3	2	1	3	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:68729192G>A	uc002ewf.2	+	14	3169	c.2037G>A	c.(2035-2037)AAG>AAA	p.K679K	CDH3_uc010vli.1_Silent_p.K624K	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	679	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		TGGTGAGAAAGAAGCGGAAGA	0.587													11	73					0	0	0	0	A	68729192	A	A	68729192	2	1	145	1	0	0	0	0	0	0	0	1	3126	933	33	2		2	CDH3	16	68729192	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	391219	68729192	21625561	336	26756											
CHST4	10164	broad.mit.edu	37	chr16	71570718	71570718	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccgagcgcatgcacgtgctGgttctgtcttcctggcgctc	3	11	12	15	4	2	0	0	0	2	0	4	1	3	0	2	2	3	5	2	2	0	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:71570718G>T	uc002fan.2	+	2	319	c.138G>T	c.(136-138)CTG>CTT	p.L46L	CHST4_uc002fao.2_Silent_p.L46L	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	46	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						TGCACGTGCTGGTTCTGTCTT	0.557													5	189					0.000602214	0.00087997	1	0	T	71570718	T	T	71570718	2	4	145	1	0	0	0	0	0	0	0	1	3421	1335	47	4		4	CHST4	16	71570718	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2841526	71570718	18784035	337	26757											
ATP2C2	9914	broad.mit.edu	37	chr16	84485542	84485542	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagtgctggccctggcttCtgggcccgagctggggcggc	2	8	17	14	2	2	0	1	0	1	0	2	1	2	0	2	6	2	3	2	6	0	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:84485542C>G	uc002fhx.2	+	18	1765	c.1676C>G	c.(1675-1677)TCT>TGT	p.S559C	ATP2C2_uc010chj.2_Missense_Mutation_p.S559C|ATP2C2_uc002fhy.2_Missense_Mutation_p.S576C|ATP2C2_uc002fhz.2_Missense_Mutation_p.S408C	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	559	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						GCCCTGGCTTCTGGGCCCGAG	0.542													25	308					0	0	0	0	G	84485542	G	G	84485542	3	3	145	1	0	0	0	0	1	0	0	0	1146	913	32	2	1746	2	ATP2C2	16	84485542	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	12914824	84485542	5869211	338	26758											
ANKRD11	29123	broad.mit.edu	37	chr16	89371734	89371734	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagttttggggtcttggttaGagaaactttatctttatcct	8	18	9	6	0	2	1	0	0	2	1	3	2	3	1	1	3	1	2	1	3	4	8			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:89371734G>C	uc002fmx.1	-	4	567	c.106C>G	c.(106-108)CTA>GTA	p.L36V	ANKRD11_uc002fmy.1_Missense_Mutation_p.L36V|ANKRD11_uc002fnc.1_Missense_Mutation_p.L36V|ANKRD11_uc002fnd.2_5'UTR|ANKRD11_uc002fne.2_5'UTR|ANKRD11_uc002fng.1_Missense_Mutation_p.L36V|ANKRD11_uc002fnf.1_Missense_Mutation_p.L36V	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	36						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GTCTTGGTTAGAGAAACTTTA	0.507													7	115					0	0	0	0	C	89371734	C	C	89371734	3	2	145	1	0	0	0	0	1	0	0	0	639	933	33	2	7925	2	ANKRD11	16	89371734	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4886192	89371734	983019	339	26759											
SMYD4	114826	broad.mit.edu	37	chr17	1703541	1703541	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgacctgattgttgctttCaggtaaacagatgtccttgt	8	16	9	8	0	1	3	1	2	0	1	2	3	2	3	2	1	2	3	2	1	2	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:1703541C>T	uc002ftm.3	-	5	1315	c.1147G>A	c.(1147-1149)GAA>AAA	p.E383K	SMYD4_uc002ftn.1_Missense_Mutation_p.E238K	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	383							zinc ion binding			skin(3)|kidney(2)	5						TTGTTGCTTTCAGGTAAACAG	0.418													17	196					0	0	0	0	T	1703541	T	T	1703541	3	4	145	1	0	0	0	0	1	0	0	0	14888	835	29	2	1295	2	SMYD4	17	1703541	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08		1703541	79491669	340	26760											
RPA1	6117	broad.mit.edu	37	chr17	1747221	1747221	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttctgtcctagaacatccGtcccattactacggggaata	10	13	7	11	2	1	1	0	0	1	1	4	2	4	2	3	2	3	0	3	2	6	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:1747221G>A	uc002fto.2	+	3	207	c.92G>A	c.(91-93)CGT>CAT	p.R31H		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	31					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TAGAACATCCGTCCCATTACT	0.488								NER					69	36					0	0	0	0	A	1747221	A	A	1747221	3	1	145	1	0	0	0	0	1	0	0	0	13601	1145	40	1	102	1	RPA1	17	1747221	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	43680	1747221	79447989	341	26761											
METT10D	79066	broad.mit.edu	37	chr17	2323539	2323539	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccaaaacctccacccctcCcttttcctcactcctttcat	7	14	0	20	0	2	0	2	0	0	0	7	0	7	0	8	0	1	0	8	0	2	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:2323539C>A	uc002fut.2	-	10	1562	c.1414G>T	c.(1414-1416)GGA>TGA	p.G472*	METT10D_uc002fuu.3_RNA|METT10D_uc010cka.2_RNA|METT10D_uc002fuv.2_Intron|METT10D_uc010vqx.1_RNA|METT10D_uc010vqy.1_Nonsense_Mutation_p.G254*	NM_024086	NP_076991	Q86W50	MET16_HUMAN	methyltransferase 10 domain containing	472							methyltransferase activity				0						TCCACCCCTCCCTTTTCCTCA	0.617													95	281					6.44939e-38	1.178e-37	1	0	A	2323539	A	A	2323539	4	1	145	1	0	0	0	0	0	1	0	0	9543	632	22	4	278	4	METT10D	17	2323539	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	576318	2323539	78871671	342	26762											
CAMTA2	23125	broad.mit.edu	37	chr17	4883457	4883457	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcccccctccatatgtctggCccctctgggggctgttgaga	4	10	12	15	0	2	1	0	1	2	1	3	2	3	1	6	3	0	2	6	3	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:4883457C>A	uc002gah.1	-	9	1268	c.1160G>T	c.(1159-1161)GGC>GTC	p.G387V	CAMTA2_uc010cku.1_Missense_Mutation_p.G410V|CAMTA2_uc002gag.1_Missense_Mutation_p.G386V|CAMTA2_uc002gai.1_Missense_Mutation_p.G389V|CAMTA2_uc010ckv.1_Missense_Mutation_p.G34V|CAMTA2_uc010vsu.1_Missense_Mutation_p.G200V	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	387					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						ATATGTCTGGCCCCTCTGGGG	0.617													28	79					4.7796e-09	7.37542e-09	1	0	A	4883457	A	A	4883457	3	1	145	1	0	0	0	0	1	0	0	0	2626	739	26	4	2558	4	CAMTA2	17	4883457	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	2559918	4883457	76311753	343	26763											
TP53	7157	broad.mit.edu	37	chr17	7578469	7578469	+	Frame_Shift_Del	DEL	C	-	-																															ccatggcgcggacgcgggtgCcgggcgggggtgtggaatca																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:7578469delC	uc002gim.2	-	5	655	c.461delG	c.(460-462)GGCfs	p.G154fs	TP53_uc002gig.1_Frame_Shift_Del_p.G154fs|TP53_uc002gih.2_Frame_Shift_Del_p.G154fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.G22fs|TP53_uc010cng.1_Frame_Shift_Del_p.G22fs|TP53_uc002gii.1_Frame_Shift_Del_p.G22fs|TP53_uc010cnh.1_Frame_Shift_Del_p.G154fs|TP53_uc010cni.1_Frame_Shift_Del_p.G154fs|TP53_uc002gij.2_Frame_Shift_Del_p.G154fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.G61fs|TP53_uc002gio.2_Frame_Shift_Del_p.G22fs|TP53_uc010vug.1_Frame_Shift_Del_p.G115fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	154	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> D (in sporadic cancers; somatic mutation).|G -> S (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|G -> I (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G154V(36)|p.G154G(12)|p.G154S(9)|p.0?(7)|p.G154D(6)|p.P152fs*14(4)|p.G154I(3)|p.G154fs*27(3)|p.G154fs*16(2)|p.G154fs*14(2)|p.P153fs*26(2)|p.P153fs*22(2)|p.P151_V173del23(1)|p.G154_R156delGTR(1)|p.G154C(1)|p.Q144_G154del11(1)|p.D148_T155delDSTPPPGT(1)|p.G154A(1)|p.S149fs*72(1)|p.G154fs*22(1)|p.D148fs*23(1)|p.P153_G154insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACGCGGGTGCCGGGCGGGGG	0.607		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578469	-	-	7578469	7	5	145	1	0	1	0	1	0	0	0	0	16448	739	26	0	837	0	TP53	17	7578469	Frame_Shift_Del	DEL	C	TCGA-CR-7374-01A-11D-2012-08	2695012	7578469	73616741	344	26764											
MYH4	4622	broad.mit.edu	37	chr17	10353772	10353772	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcactaaaagcacatacttGgcctcctccagctcctctgt	9	11	6	15	0	1	0	0	0	1	0	4	0	4	0	4	1	4	3	4	1	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:10353772G>T	uc002gmn.2	-	30	4290	c.4179C>A	c.(4177-4179)GCC>GCA	p.A1393A	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1393	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GCACATACTTGGCCTCCTCCA	0.517													83	171					2.93416e-43	5.44263e-43	1	0	T	10353772	T	T	10353772	2	4	145	1	0	0	0	0	0	0	0	1	10090	1335	47	4		4	MYH4	17	10353772	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2775303	10353772	70841438	345	26765											
MYO15A	51168	broad.mit.edu	37	chr17	18070960	18070960	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgccggccagccggcccagCgagcagctgctgcagcaggt	6	4	16	15	3	0	0	0	0	0	0	0	1	0	0	4	3	8	5	4	3	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:18070960C>T	uc010vxh.1	+	61	10343	c.10005C>T	c.(10003-10005)AGC>AGT	p.S3335S	MYO15A_uc010vxi.1_Silent_p.S599S|MYO15A_uc010vxk.1_Silent_p.S28S|MYO15A_uc010vxl.1_Silent_p.S324S|MYO15A_uc002gsl.2_Silent_p.S342S|MYO15A_uc010vxm.1_Intron|MYO15A_uc010cpv.2_RNA	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3335	Tail.|FERM.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GCCGGCCCAGCGAGCAGCTGC	0.662													23	45					0	0	0	0	T	18070960	T	T	18070960	2	4	145	1	0	0	0	0	0	0	0	1	10116	767	27	1		1	MYO15A	17	18070960	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	7717188	18070960	63124250	346	26766											
NF1	4763	broad.mit.edu	37	chr17	29490331	29490331	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaacttcggaattctgcctCtggggttttattttctctca	6	18	8	9	1	4	1	1	1	3	0	6	2	4	2	1	3	2	1	1	3	3	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:29490331C>G	uc002hgg.2	+	4	749	c.416C>G	c.(415-417)TCT>TGT	p.S139C	NF1_uc002hge.1_Missense_Mutation_p.S139C|NF1_uc002hgf.1_Missense_Mutation_p.S139C|NF1_uc002hgh.2_Missense_Mutation_p.S139C|NF1_uc010csn.1_Missense_Mutation_p.L35V	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	139					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(5)|p.?(4)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AATTCTGCCTCTGGGGTTTTA	0.443			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			3	96					0	0	0	0	G	29490331	G	G	29490331	3	3	145	1	0	0	0	0	1	0	0	0	10410	913	32	2	430	2	NF1	17	29490331	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	11419371	29490331	51704879	347	26767											
NF1	4763	broad.mit.edu	37	chr17	29528502	29528502	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actccatcgaatcatcaccaAtgtaagtccaaaaggtattg	15	10	6	10	1	2	0	2	0	0	0	5	1	4	0	3	1	0	2	3	1	6	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:29528502A>T	uc002hgg.2	+	11	1592	c.1259A>T	c.(1258-1260)AAT>ATT	p.N420I	NF1_uc002hge.1_Missense_Mutation_p.N420I|NF1_uc002hgf.1_Missense_Mutation_p.N420I|NF1_uc002hgh.2_Missense_Mutation_p.N420I|NF1_uc010csn.1_Missense_Mutation_p.N280I	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	420					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATCATCACCAATGTAAGTCCA	0.313			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			148	90					0	0	0	0	T	29528502	T	T	29528502	3	4	145	1	0	0	0	0	1	0	0	0	10410	115	4	5	1301	5	NF1	17	29528502	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	38171	29528502	51666708	348	26768											
EVI2B	2124	broad.mit.edu	37	chr17	29631403	29631403	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttggtttttcataaaatCtactggtggcaggggcaagt	9	15	11	6	0	3	0	1	0	2	0	3	0	3	0	0	5	1	3	0	5	4	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:29631403C>T	uc002hgk.2	-	2	1380	c.1225G>A	c.(1225-1227)GAT>AAT	p.D409N	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.D424N	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	409	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		TTCATAAAATCTACTGGTGGC	0.423													40	91					0	0	0	0	T	29631403	T	T	29631403	3	4	145	1	0	0	0	0	1	0	0	0	5312	913	32	2	125	2	EVI2B	17	29631403	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	102901	29631403	51563807	349	26769											
MYO19	80179	broad.mit.edu	37	chr17	34863652	34863652	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catccctcacctgctgggccCttaggtagtgagccacaaaa	10	8	9	14	0	1	1	1	1	0	0	2	1	2	1	4	2	2	2	4	2	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:34863652C>G	uc010wcy.1	-	16	2335	c.1343G>C	c.(1342-1344)AGG>ACG	p.R448T	MYO19_uc002hmw.2_Intron|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	448	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTGCTGGGCCCTTAGGTAGTG	0.512													14	29					0	0	0	0	G	34863652	G	G	34863652	3	3	145	1	0	0	0	0	1	0	0	0	10120	681	24	4	1617	4	MYO19	17	34863652	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	5232249	34863652	46331558	350	26770											
KRT24	192666	broad.mit.edu	37	chr17	38858167	38858167	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaatgatcccagcattttCaacagtggcagcaatgatct	14	10	7	10	0	2	2	1	2	1	0	3	2	3	2	1	1	3	3	1	1	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:38858167C>G	uc002hvd.2	-	2	691	c.634G>C	c.(634-636)GAA>CAA	p.E212Q		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	212	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				CCAGCATTTTCAACAGTGGCA	0.393													3	48					0	0	0	0	G	38858167	G	G	38858167	3	3	145	1	0	0	0	0	1	0	0	0	8500	835	29	2	971	2	KRT24	17	38858167	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	3994515	38858167	42337043	351	26771											
KRT24	192666	broad.mit.edu	37	chr17	38859533	38859533	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcatggtttgcttttcccctCcagagaaaagccccccatcg	8	10	8	15	1	0	1	0	0	0	1	3	2	2	1	6	1	2	3	6	1	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:38859533C>G	uc002hvd.2	-	1	470	c.413G>C	c.(412-414)GGA>GCA	p.G138A		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	138	Head.|Gly-rich.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				CTTTTCCCCTCCAGAGAAAAG	0.522													30	371					0	0	0	0	G	38859533	G	G	38859533	3	3	145	1	0	0	0	0	1	0	0	0	8500	855	30	2	1196	2	KRT24	17	38859533	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1366	38859533	42335677	352	26772											
KRT25	147183	broad.mit.edu	37	chr17	38906696	38906696	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttccaggtggagcttgatgtCcaggagctgctcatactcca	8	11	11	11	0	1	1	1	1	0	0	4	3	4	3	3	3	4	3	3	3	1	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:38906696C>G	uc002hve.2	-	6	1172	c.1111G>C	c.(1111-1113)GAC>CAC	p.D371H		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	371	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity	p.D371N(1)		ovary(2)	2		Breast(137;0.00526)				AGCTTGATGTCCAGGAGCTGC	0.527													91	337					0	0	0	0	G	38906696	G	G	38906696	3	3	145	1	0	0	0	0	1	0	0	0	8501	855	30	2	253	2	KRT25	17	38906696	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	47163	38906696	42288514	353	26773											
KRT25	147183	broad.mit.edu	37	chr17	38906822	38906822	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtagttgctctcggtctCtgtcaaggagcactccaggg	8	10	12	11	1	3	0	1	0	2	0	6	1	4	1	1	3	2	4	1	3	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:38906822C>A	uc002hve.2	-	6	1046	c.985G>T	c.(985-987)GAG>TAG	p.E329*		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	329	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				CTCTCGGTCTCTGTCAAGGAG	0.527													64	311					7.75977e-34	1.40303e-33	1	0	A	38906822	A	A	38906822	4	1	145	1	0	0	0	0	0	1	0	0	8501	922	32	2	379	2	KRT25	17	38906822	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	126	38906822	42288388	354	26774											
ABCA10	10349	broad.mit.edu	37	chr17	67197788	67197788	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttaaggaaaaataatggaGaatccccatggccatcttta	16	10	7	8	0	1	1	0	0	1	1	2	3	2	2	3	3	0	0	3	3	6	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:67197788G>A	uc010dfa.1	-	11	1907	c.1028C>T	c.(1027-1029)TCT>TTT	p.S343F	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_5'UTR|ABCA10_uc010dfc.1_Intron	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	343					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					AAATAATGGAGAATCCCCATG	0.318													13	56					0	0	0	0	A	67197788	A	A	67197788	3	1	145	1	0	0	0	0	1	0	0	0	29	942	33	2	3723	2	ABCA10	17	67197788	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	28290966	67197788	13997422	355	26775											
C17orf95	124512	broad.mit.edu	37	chr17	74729274	74729274	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaagatattatccttgcatCtgatgtgttctttgaaccag	11	15	7	8	0	2	3	0	2	2	1	3	3	3	3	2	0	2	2	2	0	4	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:74729274C>G	uc002jsr.2	+	3	631	c.299C>G	c.(298-300)TCT>TGT	p.S100C	C17orf95_uc002jsp.2_Missense_Mutation_p.S100C|C17orf95_uc002jsq.2_RNA|C17orf95_uc002jss.2_Missense_Mutation_p.S100C|C17orf95_uc002jst.2_Missense_Mutation_p.S33C|C17orf95_uc002jsu.2_Intron|MFSD11_uc002jsz.1_5'Flank|MFSD11_uc002jta.2_5'Flank	NM_001080510	NP_001073979	Q86XA0	MET23_HUMAN	hypothetical protein LOC124512	100						integral to membrane	methyltransferase activity				0						ATCCTTGCATCTGATGTGTTC	0.403													4	60					0	0	0	0	G	74729274	G	G	74729274	3	3	145	1	0	0	0	0	1	0	0	0	1900	913	32	2	305	2	C17orf95	17	74729274	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	7531486	74729274	6465936	356	26776											
RNF213	57674	broad.mit.edu	37	chr17	78327389	78327389	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcacatcaggggaggtggcaGaggtggcagaggaggccatg	10	4	20	7	0	1	2	1	0	0	2	1	4	1	4	1	8	0	3	1	8	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:78327389G>C	uc002jyh.1	+	9	4943	c.4720G>C	c.(4720-4722)GAG>CAG	p.E1574Q	uc002jyi.1_RNA|RNF213_uc010dhw.1_5'Flank	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GGAGGTGGCAGAGGTGGCAGA	0.567													5	78					0	0	0	0	C	78327389	C	C	78327389	3	2	145	1	0	0	0	0	1	0	0	0	13542	943	33	2	10950	2	RNF213	17	78327389	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3598115	78327389	2867821	357	26777											
FLJ35220	284131	broad.mit.edu	37	chr17	78388916	78388916	+	5'Flank	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccgggaaagcgcaagcgtctCcatggcaacgagggcggacg	10	3	16	12	6	1	0	0	0	1	0	2	3	1	2	2	4	3	2	2	4	3	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:78388916C>G	uc002jym.1	+						uc002jyi.1_RNA|FLJ35220_uc002jyj.1_5'Flank|FLJ35220_uc002jyk.2_5'Flank|FLJ35220_uc002jyl.1_5'Flank|FLJ35220_uc002jyn.2_5'Flank	NM_173627	NP_775898	Q8N8Q3	ENDOV_HUMAN	hypothetical protein LOC284131 isoform 1						DNA repair		endodeoxyribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			GCAAGCGTCTCCATGGCAACG	0.706								Direct_reversal_of_damage|Editing_and_processing_nucleases					3	22					0	0	0	0	G	78388916	G	G	78388916	1	3	145	0	1	0	0	0	0	0	0	0	5959	870	30	2		2	FLJ35220	17	78388916	5'Flank	SNP	C	TCGA-CR-7374-01A-11D-2012-08	61527	78388916	2806294	358	26778											
KIAA0802	23255	broad.mit.edu	37	chr18	8783661	8783661	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccagaagtacaagtccctctAtggggatgtggacagtcccc	10	8	11	12	0	1	1	0	0	1	1	3	3	3	3	4	3	1	1	4	3	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:8783661A>C	uc002knr.2	+	6	693	c.551A>C	c.(550-552)TAT>TCT	p.Y184S	KIAA0802_uc002knq.2_Missense_Mutation_p.Y184S|KIAA0802_uc010dkw.1_Missense_Mutation_p.Y22S	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	535	Potential.										0						AAGTCCCTCTATGGGGATGTG	0.612													3	44					0	0	0	0	C	8783661	C	C	8783661	3	2	145	1	0	0	0	0	1	0	0	0	8233	449	16	5	565	5	KIAA0802	18	8783661	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08		8783661	69293587	359	26779											
POTEC	388468	broad.mit.edu	37	chr18	14542977	14542977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttgcccatcttgctcctgaGcatcttcataaaggagtcgt	8	13	8	12	1	3	1	1	1	2	0	5	2	4	2	2	1	3	2	2	1	2	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:14542977G>A	uc010dln.2	-	1	623	c.169C>T	c.(169-171)CTC>TTC	p.L57F	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	57										skin(3)	3						TTGCTCCTGAGCATCTTCATA	0.587													108	691					0	0	0	0	A	14542977	A	A	14542977	3	1	145	1	0	0	0	0	1	0	0	0	12317	971	34	4	1503	4	POTEC	18	14542977	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	5759316	14542977	63534271	360	26780											
DSG3	1830	broad.mit.edu	37	chr18	29052738	29052738	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagccaatggagccgatttCatggaaagttctggtaagtg	12	10	12	7	1	2	0	1	0	1	0	2	3	2	2	2	3	2	2	2	3	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:29052738C>T	uc002kws.2	+	14	2197	c.2088C>T	c.(2086-2088)TTC>TTT	p.F696F	DSG3_uc002kwt.2_5'Flank	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	696	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GAGCCGATTTCATGGAAAGTT	0.323													4	53					0	0	0	0	T	29052738	T	T	29052738	2	4	145	1	0	0	0	0	0	0	0	1	4800	825	29	2		2	DSG3	18	29052738	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	14509761	29052738	49024510	361	26781											
ASXL3	80816	broad.mit.edu	37	chr18	31325388	31325388	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgttaaaggggtgccttGtgtcatcagttccggcatca	9	12	12	8	1	3	1	3	0	0	1	4	1	4	1	2	3	1	3	2	3	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:31325388G>T	uc010dmg.1	+	12	5631	c.5576G>T	c.(5575-5577)TGT>TTT	p.C1859F	ASXL3_uc002kxq.2_Missense_Mutation_p.C1566F	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1859					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GGGGTGCCTTGTGTCATCAGT	0.468													18	548					1.33834e-09	2.08769e-09	1	0	T	31325388	T	T	31325388	3	4	145	1	0	0	0	0	1	0	0	0	1070	1377	48	4	5622	4	ASXL3	18	31325388	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2272650	31325388	46751860	362	26782											
ELP2	55250	broad.mit.edu	37	chr18	33750144	33750144	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcagcgtctgcccagtgcTccacccttctcaacggtcag	6	10	9	16	2	4	0	3	0	2	0	6	0	5	0	3	1	4	1	3	1	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:33750144T>G	uc002kzk.1	+	20	2205	c.2195T>G	c.(2194-2196)CTC>CGC	p.L732R	ELP2_uc010xcg.1_Missense_Mutation_p.L797R|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Missense_Mutation_p.L706R|ELP2_uc010xch.1_Missense_Mutation_p.L727R|ELP2_uc002kzn.1_Missense_Mutation_p.L662R|ELP2_uc002kzo.1_Missense_Mutation_p.L662R	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	732	WD 13.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						TGCCCAGTGCTCCACCCTTCT	0.512													54	98					0	0	0	0	G	33750144	G	G	33750144	3	3	145	1	0	0	0	0	1	0	0	0	5104	1551	54	5	2273	5	ELP2	18	33750144	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	2424756	33750144	44327104	363	26783											
RIT2	6014	broad.mit.edu	37	chr18	40613778	40613778	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaggaagcttccacttacctAtagtagggtcatgataatca	14	11	8	8	0	2	1	2	1	0	0	3	2	3	2	2	2	2	2	2	2	7	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:40613778A>G	uc002lav.2	-	2	331	c.158T>C	c.(157-159)ATA>ACA	p.I53T	RIT2_uc010dnf.2_Missense_Mutation_p.I53T	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	53					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						CCACTTACCTATAGTAGGGTC	0.308													21	17					0	0	0	0	G	40613778	G	G	40613778	3	3	145	1	0	0	0	0	1	0	0	0	13452	449	16	5	511	5	RIT2	18	40613778	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	6863634	40613778	37463470	364	26784											
SLC14A1	6563	broad.mit.edu	37	chr18	43310367	43310367	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtttcgccatgtcaagggAgaaggtgcttccccaaagct	10	9	12	10	1	1	1	1	0	0	1	3	2	2	1	3	3	2	3	3	3	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:43310367A>G	uc010xcn.1	+	4	401	c.82A>G	c.(82-84)AGA>GGA	p.R28G	SLC14A1_uc010dnk.2_Missense_Mutation_p.R84G|SLC14A1_uc002lbf.3_Missense_Mutation_p.R28G|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Intron|SLC14A1_uc002lbh.3_Intron|SLC14A1_uc002lbi.3_Intron|SLC14A1_uc002lbj.3_Missense_Mutation_p.R84G|SLC14A1_uc002lbk.3_Missense_Mutation_p.R28G	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	28						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						ATGTCAAGGGAGAAGGTGCTT	0.498													6	121					0	0	0	0	G	43310367	G	G	43310367	3	3	145	1	0	0	0	0	1	0	0	0	14461	296	11	5	256	5	SLC14A1	18	43310367	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	2696589	43310367	34766881	365	26785											
AP3D1	8943	broad.mit.edu	37	chr19	2109958	2109958	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggtcgcaccctcgtcattCtgcggtggagtgaaggtggt	5	11	16	9	3	2	1	1	1	1	0	4	2	2	2	1	5	1	1	1	5	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:2109958C>G	uc002luz.2	-	27	3302	c.3079_splice	c.e27-1	p.N1027_splice	AP3D1_uc010dsv.2_Splice_Site_p.N117_splice|AP3D1_uc002luy.2_Splice_Site_p.N986_splice|AP3D1_uc002lva.2_Splice_Site_p.N1089_splice	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1						eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCGTCATTCTGCGGTGGAG	0.642													19	56					0	0	0	0	G	2109958	G	G	2109958	5	3	145	1	0	0	0	0	0	0	1	0	746	927	32	2	399	2	AP3D1	19	2109958	Splice_Site	SNP	C	TCGA-CR-7374-01A-11D-2012-08		2109958	57019025	366	26786											
EMR1	2015	broad.mit.edu	37	chr19	6924814	6924814	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacaacacctacctccacctGcacctctgcgtgtgtctcct	7	10	5	19	1	2	0	0	0	2	0	4	0	3	0	6	0	4	1	6	0	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:6924814G>T	uc002mfw.2	+	15	1955	c.1917G>T	c.(1915-1917)CTG>CTT	p.L639L	EMR1_uc010dvc.2_Intron|EMR1_uc010dvb.2_Silent_p.L587L|EMR1_uc010xji.1_Silent_p.L498L|EMR1_uc010xjj.1_Silent_p.L462L	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	639	Helical; Name=2; (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					ACCTCCACCTGCACCTCTGCG	0.552													35	111					5.43694e-19	8.99041e-19	1	0	T	6924814	T	T	6924814	2	4	145	1	0	0	0	0	0	0	0	1	5128	1306	46	4		4	EMR1	19	6924814	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4814856	6924814	52204169	367	26787											
PCP2	126006	broad.mit.edu	37	chr19	7697683	7697683	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccctgcacgtggctcagcaGattgaagaagccctcctggt	8	8	12	13	1	1	3	1	1	0	2	2	3	2	3	3	2	3	3	3	2	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:7697683G>A	uc002mgz.2	-	2	312	c.85C>T	c.(85-87)CTG>TTG	p.L29L		NM_174895	NP_777555	Q8IVA1	PCP2_HUMAN	Purkinje cell protein 2	29	GoLoco 1.				signal transduction		GTPase activator activity				0						TGGCTCAGCAGATTGAAGAAG	0.672													5	4					0	0	0	0	A	7697683	A	A	7697683	2	1	145	1	0	0	0	0	0	0	0	1	11651	933	33	2		2	PCP2	19	7697683	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	772869	7697683	51431300	368	26788											
LRRC8E	80131	broad.mit.edu	37	chr19	7965435	7965435	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagctcggcctgtgctcAggcctccgtctgctggatgt	3	11	12	15	2	2	0	1	0	1	0	5	1	4	1	4	3	3	3	4	3	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:7965435A>T	uc002mir.2	+	3	2129	c.2028A>T	c.(2026-2028)TCA>TCT	p.S676S		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	676						integral to membrane				lung(1)|pancreas(1)	2						GCCTGTGCTCAGGCCTCCGTC	0.632													36	63					0	0	0	0	T	7965435	T	T	7965435	2	4	145	1	0	0	0	0	0	0	0	1	9075	175	7	5		5	LRRC8E	19	7965435	Silent	SNP	A	TCGA-CR-7374-01A-11D-2012-08	267752	7965435	51163548	369	26789											
MUC16	94025	broad.mit.edu	37	chr19	9003657	9003657	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaggttagtgatggtaaaaTtgagggtgaatggcagcagg	12	9	17	3	0	0	3	0	3	0	0	0	3	0	3	0	5	1	5	0	5	4	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:9003657T>G	uc002mkp.2	-	49	40187	c.39983A>C	c.(39982-39984)AAT>ACT	p.N13328T	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.N145T|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13330	Extracellular (Potential).|SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATGGTAAAATTGAGGGTGAA	0.483													33	379					0	0	0	0	G	9003657	G	G	9003657	3	3	145	1	0	0	0	0	1	0	0	0	10026	1493	52	5	3684	5	MUC16	19	9003657	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	1038222	9003657	50125326	370	26790											
MUC16	94025	broad.mit.edu	37	chr19	9069584	9069584	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagggaagtcacagggagAgcagaagtggggctacttcc	13	5	16	7	0	1	3	1	0	0	3	2	5	2	4	1	4	2	2	1	4	4	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:9069584A>T	uc002mkp.2	-	3	18066	c.17862T>A	c.(17860-17862)GCT>GCA	p.A5954A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5956	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCACAGGGAGAGCAGAAGTGG	0.488													54	107					0	0	0	0	T	9069584	T	T	9069584	2	4	145	1	0	0	0	0	0	0	0	1	10026	291	11	5		5	MUC16	19	9069584	Silent	SNP	A	TCGA-CR-7374-01A-11D-2012-08	65927	9069584	50059399	371	26791											
GADD45GIP1	90480	broad.mit.edu	37	chr19	13067806	13067806	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctccggcgacggccataacGaaccggggaccaccccggag	9	2	14	16	6	0	0	0	0	0	0	1	4	1	2	6	5	2	1	6	5	2	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:13067806G>A	uc002mwb.2	-	1	245	c.221C>T	c.(220-222)TCG>TTG	p.S74L		NM_052850	NP_443082	Q8TAE8	G45IP_HUMAN	growth arrest and DNA-damage-inducible, gamma	74					cell cycle|interspecies interaction between organisms	nucleus	protein binding			ovary(1)|skin(1)	2						CGGCCATAACGAACCGGGGAC	0.706													17	26					0	0	0	0	A	13067806	A	A	13067806	3	1	145	1	0	0	0	0	1	0	0	0	6218	1059	37	1	455	1	GADD45GIP1	19	13067806	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	3998222	13067806	46061177	372	26792											
RFX1	5989	broad.mit.edu	37	chr19	14090331	14090331	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccgggtttgggcgcttgTggagtggcctggaccacaga	5	8	19	9	2	0	1	0	0	0	1	0	3	0	3	3	6	0	2	3	6	0	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:14090331T>A	uc002mxv.2	-	7	1034	c.762A>T	c.(760-762)CCA>CCT	p.P254P	RFX1_uc010dzi.2_Silent_p.P254P	NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	254					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			TGGGCGCTTGTGGAGTGGCCT	0.642													38	120					0	0	0	0	A	14090331	A	A	14090331	2	1	145	1	0	0	0	0	0	0	0	1	13327	1683	59	5		5	RFX1	19	14090331	Silent	SNP	T	TCGA-CR-7374-01A-11D-2012-08	1022525	14090331	45038652	373	26793											
ZNF14	7561	broad.mit.edu	37	chr19	19822966	19822966	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catgcaatcgaagagaaatgGaccaactgaatgatttgcca	16	8	9	8	1	0	3	0	2	0	1	1	6	0	4	2	1	3	1	2	1	5	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:19822966G>A	uc002nnk.1	-	4	1278	c.1124C>T	c.(1123-1125)TCC>TTC	p.S375F		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	375	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				AAGAGAAATGGACCAACTGAA	0.373													17	116					0	0	0	0	A	19822966	A	A	19822966	3	1	145	1	0	0	0	0	1	0	0	0	17795	1174	41	2	808	2	ZNF14	19	19822966	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	5732635	19822966	39306017	374	26794											
MAG	4099	broad.mit.edu	37	chr19	35800952	35800952	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcggagcgcagcggcctcgtGctcaccagcatcctcacgct	6	7	11	17	5	2	0	2	0	0	0	5	1	3	1	3	2	4	4	3	2	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:35800952G>T	uc002nyy.1	+	8	1556	c.1407G>T	c.(1405-1407)GTG>GTT	p.V469V	MAG_uc002nyx.1_Silent_p.V469V|MAG_uc010eds.1_Silent_p.V444V|MAG_uc002nyz.1_Silent_p.V469V	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	469	Ig-like C2-type 4.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GCGGCCTCGTGCTCACCAGCA	0.687													44	46					6.68952e-21	1.1377e-20	1	0	T	35800952	T	T	35800952	2	4	145	1	0	0	0	0	0	0	0	1	9213	1306	46	4		4	MAG	19	35800952	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	15977986	35800952	23328031	375	26795											
APLP1	333	broad.mit.edu	37	chr19	36362534	36362534	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctgcagctcccagggcctCatcctgcacggctcgggcat	5	7	12	17	2	1	0	1	0	0	0	4	0	3	0	4	3	3	5	4	3	0	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:36362534C>T	uc002oce.2	+	5	696	c.558C>T	c.(556-558)CTC>CTT	p.L186L	APLP1_uc010xsz.1_Silent_p.L147L|APLP1_uc002ocf.2_Silent_p.L186L|APLP1_uc002ocg.2_Silent_p.L89L|APLP1_uc010xta.1_Silent_p.L180L	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	186	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCAGGGCCTCATCCTGCACG	0.652													24	92					0	0	0	0	T	36362534	T	T	36362534	2	4	145	1	0	0	0	0	0	0	0	1	778	813	29	2		2	APLP1	19	36362534	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	561582	36362534	22766449	376	26796											
POU2F2	5452	broad.mit.edu	37	chr19	42597981	42597981	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cattttctgccctccctgacCtgttgtgctcagactgctgg	4	14	9	14	0	2	2	1	1	1	1	3	2	3	2	3	1	3	3	3	1	0	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:42597981C>G	uc002osp.2	-	12	1265	c.1198G>C	c.(1198-1200)GTT>CTT	p.V400L	POU2F2_uc002osn.2_Missense_Mutation_p.V384L|POU2F2_uc002oso.2_Missense_Mutation_p.V173L|POU2F2_uc002osq.2_Missense_Mutation_p.A384P|POU2F2_uc002osr.1_Missense_Mutation_p.V400L	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	400	Leucine-zipper.				humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				CCTCCCTGACCTGTTGTGCTC	0.607													15	250					0	0	0	0	G	42597981	G	G	42597981	3	3	145	1	0	0	0	0	1	0	0	0	12327	695	24	4	253	4	POU2F2	19	42597981	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	6235447	42597981	16531002	377	26797											
CIC	23152	broad.mit.edu	37	chr19	42795409	42795409	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaggtacagtacatcctgcCcacgctgccccagcagcttc	8	7	8	18	1	0	0	0	0	0	0	2	0	1	0	5	1	6	5	5	1	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:42795409C>A	uc002otf.1	+	10	2529	c.2489C>A	c.(2488-2490)CCC>CAC	p.P830H		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	830	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				TACATCCTGCCCACGCTGCCC	0.687			T	DUX4	soft tissue sarcoma								14	18					0.00244969	0.00355777	1	0	A	42795409	A	A	42795409	3	1	145	1	0	0	0	0	1	0	0	0	3439	623	22	4	2527	4	CIC	19	42795409	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	197428	42795409	16333574	378	26798											
TMEM145	284339	broad.mit.edu	37	chr19	42827922	42827922	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcacggagctcttctccaTccccccgcccgccacctccg	4	8	6	23	4	3	0	1	0	2	0	6	1	5	1	8	1	1	1	8	1	0	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:42827922T>C	uc002otk.1	+	14	1434	c.1382T>C	c.(1381-1383)ATC>ACC	p.I461T	MEGF8_uc002otl.3_5'Flank	NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	461						integral to membrane					0		Prostate(69;0.00682)				CTCTTCTCCATCCCCCCGCCC	0.582													4	104					0	0	0	0	C	42827922	C	C	42827922	3	2	145	1	0	0	0	0	1	0	0	0	16125	1435	50	5	1436	5	TMEM145	19	42827922	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	32513	42827922	16301061	379	26799											
ZNF404	342908	broad.mit.edu	37	chr19	44376785	44376785	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgactaaaggccttaccacaTtctttgcatttctgtggttt	8	17	7	9	0	2	1	0	1	2	0	2	1	2	1	2	2	2	2	2	2	3	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:44376785T>C	uc002oxs.3	-	2	1581	c.1572A>G	c.(1570-1572)GAA>GAG	p.E524E		NM_001033719	NP_001028891	Q494X3	ZN404_HUMAN	zinc finger protein 404	527	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CCTTACCACATTCTTTGCATT	0.388													19	15					0	0	0	0	C	44376785	C	C	44376785	2	2	145	1	0	0	0	0	0	0	0	1	17953	1490	52	5		5	ZNF404	19	44376785	Silent	SNP	T	TCGA-CR-7374-01A-11D-2012-08	1548863	44376785	14752198	380	26800											
KLK13	26085	broad.mit.edu	37	chr19	51563831	51563831	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccacctgggagaaacccaCtggtcccattggtgttgaga	10	8	12	11	0	0	2	0	1	0	2	1	4	1	2	4	3	2	1	4	3	1	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:51563831C>A	uc002pvn.2	-	2	141	c.98G>T	c.(97-99)AGT>ATT	p.S33I	KLK13_uc002pvl.2_RNA|KLK13_uc002pvm.2_RNA|KLK13_uc002pvo.2_RNA|KLK13_uc002pvp.2_RNA|KLK13_uc010eon.2_Missense_Mutation_p.S33I|KLK13_uc002pvq.2_RNA|KLK13_uc010eoo.2_Intron|KLK13_uc002pvr.2_Missense_Mutation_p.S33I	NM_015596	NP_056411	Q9UKR3	KLK13_HUMAN	kallikrein 13 precursor	33					proteolysis		protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		GAGAAACCCACTGGTCCCATT	0.582													69	85					1.33801e-20	2.25947e-20	1	0	A	51563831	A	A	51563831	3	1	145	1	0	0	0	0	1	0	0	0	8440	565	20	4	751	4	KLK13	19	51563831	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	7187046	51563831	7565152	381	26801											
ZNF615	284370	broad.mit.edu	37	chr19	52497539	52497539	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggaaggttttgtcacattCagtgcattcataatgtttca	11	15	9	6	0	4	0	4	0	0	0	4	2	4	1	0	2	1	3	0	2	2	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:52497539C>T	uc002pye.1	-	6	1082	c.790G>A	c.(790-792)GAA>AAA	p.E264K	ZNF615_uc002pyf.1_Missense_Mutation_p.E275K|ZNF615_uc002pyg.1_Missense_Mutation_p.E156K|ZNF615_uc002pyh.1_Missense_Mutation_p.E275K|ZNF615_uc010epi.1_Missense_Mutation_p.E271K|ZNF615_uc010ydg.1_Missense_Mutation_p.E269K	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	264	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TTGTCACATTCAGTGCATTCA	0.403													16	154					0	0	0	0	T	52497539	T	T	52497539	3	4	145	1	0	0	0	0	1	0	0	0	18107	835	29	2	1409	2	ZNF615	19	52497539	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	933708	52497539	6631444	382	26802											
ZNF836	162962	broad.mit.edu	37	chr19	52659425	52659426	+	Missense_Mutation	DNP	CC	AA	AA																															agccctgtttaaaggctttaCcacatttatcacatttgtaa																										TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:52659425_52659426CC>AA	uc010ydi.1	-	5	1884_1885	c.1510_1511GG>TT	c.(1510-1512)GGT>TTT	p.G504F	ZNF836_uc010ydj.1_Missense_Mutation_p.G504F	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	504	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAGGCTTTACCACATTTATCA	0.406													67	64					0	0	0	0	AA	52659426	AA	AA	52659425	3	1	145	1	0	0	0	0	1	0	0	0	18254	507	18	4	1301	4	ZNF836	19	52659425	Missense_Mutation	DNP	CC	TCGA-CR-7374-01A-11D-2012-08	161886	52659425	6469558	383	26803											
NLRP12	91662	broad.mit.edu	37	chr19	54318203	54318203	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agacttccagaaggcatgttGactggttcccaagtgaggac	11	9	12	9	0	0	4	0	2	0	2	2	5	2	5	2	3	0	3	2	3	2	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:54318203G>C	uc002qch.3	-	2	549	c.329C>G	c.(328-330)TCA>TGA	p.S110*	NLRP12_uc002qci.3_Nonsense_Mutation_p.S110*|NLRP12_uc002qcj.3_Nonsense_Mutation_p.S110*|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Nonsense_Mutation_p.S110*	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	110					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AAGGCATGTTGACTGGTTCCC	0.517													15	127					0	0	0	0	C	54318203	C	C	54318203	4	2	145	1	0	0	0	0	0	1	0	0	10528	1294	45	2	2988	2	NLRP12	19	54318203	Nonsense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1658778	54318203	4810780	384	26804											
LILRA1	11024	broad.mit.edu	37	chr19	55106848	55106848	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtctctacccagtgatctCctggagctcctggtcctagg	5	12	11	13	0	2	1	0	1	2	0	6	2	4	2	4	4	2	1	4	4	2	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:55106848C>A	uc002qgh.1	+	5	824	c.642C>A	c.(640-642)CTC>CTA	p.L214L	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Silent_p.L214L	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	214	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CCAGTGATCTCCTGGAGCTCC	0.587													13	205					6.31663e-08	9.64329e-08	1	0	A	55106848	A	A	55106848	2	1	145	1	0	0	0	0	0	0	0	1	8825	842	30	2		2	LILRA1	19	55106848	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	788645	55106848	4022135	385	26805											
C20orf194	25943	broad.mit.edu	37	chr20	3324338	3324338	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacctgttttcagttataTggctagagatcattccatga	10	16	7	8	0	2	2	2	1	0	1	3	3	3	2	2	1	1	3	2	1	4	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:3324338T>A	uc002wii.2	-	9	881	c.830A>T	c.(829-831)CAT>CTT	p.H277L	C20orf194_uc002wij.3_5'Flank|C20orf194_uc002wik.2_Intron|C20orf194_uc010gay.1_RNA	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	277											0						TTCAGTTATATGGCTAGAGAT	0.388													292	252					0	0	0	0	A	3324338	A	A	3324338	3	1	145	1	0	0	0	0	1	0	0	0	2109	1464	51	5	2819	5	C20orf194	20	3324338	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08		3324338	59701182	386	26806											
SLC23A2	9962	broad.mit.edu	37	chr20	4865411	4865411	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcttttacctctcggatccgGggataccagatgtgttctgt	6	15	10	10	2	3	1	0	0	3	1	5	3	4	3	3	3	2	1	3	3	2	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:4865411G>A	uc002wlg.1	-	8	1005	c.630C>T	c.(628-630)CCC>CCT	p.P210P	SLC23A2_uc010zqr.1_Intron|SLC23A2_uc002wlh.1_Silent_p.P210P|SLC23A2_uc002wli.2_Silent_p.P209P	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	210					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						CTCGGATCCGGGGATACCAGA	0.418													54	180					0	0	0	0	A	4865411	A	A	4865411	2	1	145	1	0	0	0	0	0	0	0	1	14527	1219	43	4		4	SLC23A2	20	4865411	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	1541073	4865411	58160109	387	26807											
INSM1	3642	broad.mit.edu	37	chr20	20350277	20350277	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgttcgccagcaagggcgctCaggagcgccacctgcgcctg	6	5	14	16	5	1	0	1	0	0	0	2	1	1	1	4	2	3	3	4	2	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:20350277C>T	uc002wrx.2	+	1	1513	c.1366C>T	c.(1366-1368)CAG>TAG	p.Q456*		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	456	C2H2-type 4.				endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		CAAGGGCGCTCAGGAGCGCCA	0.716													14	37					0	0	0	0	T	20350277	T	T	20350277	4	4	145	1	0	0	0	0	0	1	0	0	7810	827	29	2	1368	2	INSM1	20	20350277	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	15484866	20350277	42675243	388	26808											
C20orf185	359710	broad.mit.edu	37	chr20	31652345	31652345	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaaccagtacatagaactGgacatcaacgtgagtaacca	16	7	7	11	1	1	2	1	1	0	1	2	3	2	3	3	1	5	2	3	1	6	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:31652345G>T	uc002wym.1	+	7	735	c.735G>T	c.(733-735)CTG>CTT	p.L245L		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	245					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						ACATAGAACTGGACATCAACG	0.587													28	67					7.26314e-15	1.17126e-14	1	0	T	31652345	T	T	31652345	2	4	145	1	0	0	0	0	0	0	0	1	2107	1335	47	4		4	C20orf185	20	31652345	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	11302068	31652345	31373175	389	26809											
SAMHD1	25939	broad.mit.edu	37	chr20	35559189	35559189	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgacaaagtccagcaatcTgaacacagagaacatctcgt	16	7	7	11	1	2	3	0	2	2	1	4	4	3	3	1	0	3	1	1	0	4	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:35559189T>C	uc002xgh.1	-	5	729	c.599A>G	c.(598-600)CAG>CGG	p.Q200R		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	200	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				TCCAGCAATCTGAACACAGAG	0.413													64	141					0	0	0	0	C	35559189	C	C	35559189	3	2	145	1	0	0	0	0	1	0	0	0	13893	1580	55	5	1329	5	SAMHD1	20	35559189	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	3906844	35559189	27466331	390	26810											
RTEL1	51750	broad.mit.edu	37	chr20	62321524	62321524	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gacaactttggccatgtcatCcgagacgtggcccagttctt	8	11	10	12	2	2	1	1	0	1	1	3	3	3	1	3	2	1	1	3	2	1	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:62321524C>T	uc002yfu.1	+	25	2569	c.2226C>T	c.(2224-2226)ATC>ATT	p.I742I	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Silent_p.I742I|RTEL1_uc011abd.1_Silent_p.I766I|RTEL1_uc011abe.1_Silent_p.I519I|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_5'UTR	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	742					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GCCATGTCATCCGAGACGTGG	0.617													9	99					0	0	0	0	T	62321524	T	T	62321524	2	4	145	1	0	0	0	0	0	0	0	1	13785	845	30	2		2	RTEL1	20	62321524	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	26762335	62321524	703996	391	26811											
ZNF512B	57473	broad.mit.edu	37	chr20	62591451	62591451	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggcaccaatgagtcctggctCctgtgtttgggaggtgggtc	5	11	16	9	0	0	1	0	1	0	0	3	2	2	2	3	5	0	3	3	5	1	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:62591451C>G	uc002yhl.1	-	17	2523	c.2469G>C	c.(2467-2469)AGG>AGC	p.R823S		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	823					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					AGTCCTGGCTCCTGTGTTTGG	0.572													6	122					0	0	0	0	G	62591451	G	G	62591451	3	3	145	1	0	0	0	0	1	0	0	0	18024	854	30	2	213	2	ZNF512B	20	62591451	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	269927	62591451	434069	392	26812											
MRAP	56246	broad.mit.edu	37	chr21	33671361	33671361	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atctggacctcattcccgtgGacgagaagaagctgaaagcc	12	7	11	11	2	2	3	1	1	1	2	3	6	3	5	3	2	2	1	3	2	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr21:33671361G>C	uc002ypj.2	+	3	266	c.79G>C	c.(79-81)GAC>CAC	p.D27H	MRAP_uc002ypk.2_Missense_Mutation_p.D27H|MRAP_uc011ado.1_Intron|MRAP_uc002ypl.2_Missense_Mutation_p.D27H	NM_178817	NP_848932	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	27	Cytoplasmic (Potential).				positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding				0						CATTCCCGTGGACGAGAAGAA	0.582													8	91					0	0	0	0	C	33671361	C	C	33671361	3	2	145	1	0	0	0	0	1	0	0	0	9806	1174	41	2	81	2	MRAP	21	33671361	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08		33671361	14458534	393	26813											
SYNJ1	8867	broad.mit.edu	37	chr21	34003713	34003713	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagagaagggaaaggactGatagtaacgggctcttcttt	12	10	13	6	1	2	2	0	1	2	1	2	5	2	4	0	3	2	3	0	3	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr21:34003713G>A	uc002yqh.2	-	32	4431	c.4431C>T	c.(4429-4431)ATC>ATT	p.I1477I	SYNJ1_uc011ads.1_3'UTR|SYNJ1_uc002yqf.2_3'UTR|SYNJ1_uc002yqg.2_Silent_p.I1391I|SYNJ1_uc002yqi.2_3'UTR|SYNJ1_uc002yqe.3_Silent_p.I63I	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1438	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						GGAAAGGACTGATAGTAACGG	0.468													19	67					0	0	0	0	A	34003713	A	A	34003713	2	1	145	1	0	0	0	0	0	0	0	1	15518	1280	45	2		2	SYNJ1	21	34003713	Silent	SNP	G	TCGA-CR-7374-01A-11D-2012-08	332352	34003713	14126182	394	26814											
TMEM50B	757	broad.mit.edu	37	chr21	34853826	34853827	+	5'Flank	INS	-	G	G																															caaatctcatcactttttttINSgggggggtgggggaggcatc																								rs139799615	by1000genomes	TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr21:34853826_34853827insG	uc002yrt.1	-						TMEM50B_uc002yrs.1_5'Flank|TMEM50B_uc010gmb.1_5'Flank	NM_006134	NP_006125	P56557	TM50B_HUMAN	transmembrane protein 50B							endoplasmic reticulum|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TCACTTTTTTTGGGGGGGTGGG	0.317													---	---	---								G	34853827	G	G	34853826	6	5	145	0	1	1	1	0	0	0	0	0	16242	1827	63	0		0	TMEM50B	21	34853826	5'Flank	INS	-	TCGA-CR-7374-01A-11D-2012-08	850113	34853826	13276069	395	26815											
DSCAM	1826	broad.mit.edu	37	chr21	42080487	42080487	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgaagcttgaaggagggaagGggaaaatttggagagtgccg	13	7	18	3	1	0	3	0	2	0	1	0	7	0	6	1	5	2	1	1	5	5	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr21:42080487G>A	uc002yyq.1	-	2	706	c.254C>T	c.(253-255)CCC>CTC	p.P85L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	85	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGGAGGGAAGGGGAAAATTTG	0.498													5	110					0	0	0	0	A	42080487	A	A	42080487	3	1	145	1	0	0	0	0	1	0	0	0	4790	1232	43	4	5912	4	DSCAM	21	42080487	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	7226661	42080487	6049408	396	26816											
XBP1	7494	broad.mit.edu	37	chr22	29191483	29191483	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attagcttggctctctgtctCagagggtatctctaagacta	9	14	9	9	0	3	2	1	0	3	2	6	2	3	2	0	2	1	3	0	2	4	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:29191483C>G	uc011akl.1	-	6	859	c.811G>C	c.(811-813)GAG>CAG	p.E271Q	XBP1_uc003aec.2_Missense_Mutation_p.E92Q|XBP1_uc003aed.2_3'UTR|XBP1_uc003aef.2_Missense_Mutation_p.E92Q	NM_001079539	NP_001073007	P17861	XBP1_HUMAN	X-box binding protein 1 isoform XBP1(S)	Error:Variant_position_missing_in_P17861_after_alignment					immune response	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CTCTCTGTCTCAGAGGGTATC	0.463													4	39					0	0	0	0	G	29191483	G	G	29191483	3	3	145	1	0	0	0	0	1	0	0	0	17490	835	29	2	323	2	XBP1	22	29191483	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08		29191483	22113083	397	26817											
THOC5	8563	broad.mit.edu	37	chr22	29940543	29940543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgtataactcatagtctctgCcagggtcccgcagatccacc	9	10	8	14	1	2	1	1	0	1	1	5	1	4	1	4	1	2	2	4	1	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:29940543C>T	uc003afr.2	-	4	481	c.146G>A	c.(145-147)GGC>GAC	p.G49D	THOC5_uc003afs.2_Missense_Mutation_p.G49D|THOC5_uc003aft.2_Missense_Mutation_p.G49D|THOC5_uc003afu.2_Missense_Mutation_p.G49D|THOC5_uc010gvo.2_5'UTR|THOC5_uc003afv.1_Missense_Mutation_p.G49D|THOC5_uc003afw.1_5'Flank	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	49	Interaction with THOC7.|Interaction with CSF1R (By similarity).				intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						ATAGTCTCTGCCAGGGTCCCG	0.527													6	157					0	0	0	0	T	29940543	T	T	29940543	3	4	145	1	0	0	0	0	1	0	0	0	15934	739	26	4	1977	4	THOC5	22	29940543	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	749060	29940543	21364023	398	26818											
OSBP2	23762	broad.mit.edu	37	chr22	31091189	31091189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccaggggctgggcagccatCggaactgctgcaggggtcgc	6	5	18	12	2	0	0	0	0	0	0	2	1	0	1	2	6	4	4	2	6	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:31091189C>T	uc003aiy.1	+	1	397	c.293C>T	c.(292-294)TCG>TTG	p.S98L	OSBP2_uc011ala.1_Intron|OSBP2_uc010gwc.1_Intron|OSBP2_uc003aix.1_Missense_Mutation_p.S98L|OSBP2_uc011alb.1_Missense_Mutation_p.S98L|OSBP2_uc003aiz.1_Missense_Mutation_p.S98L	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	98					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						GGGCAGCCATCGGAACTGCTG	0.667													9	76					0	0	0	0	T	31091189	T	T	31091189	3	4	145	1	0	0	0	0	1	0	0	0	11328	893	31	1	295	1	OSBP2	22	31091189	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1150646	31091189	20213377	399	26819											
GRAMD4	23151	broad.mit.edu	37	chr22	47033814	47033814	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgatcgactgaatgagatCaaaggtcacctggaaattgc	13	11	10	7	1	2	3	2	3	0	1	3	6	2	4	1	2	1	0	1	2	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:47033814C>T	uc003bhx.2	+	2	279	c.240C>T	c.(238-240)ATC>ATT	p.I80I	GRAMD4_uc010had.2_Silent_p.I19I	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	80					apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		TGAATGAGATCAAAGGTCACC	0.498													6	225					0	0	0	0	T	47033814	T	T	47033814	2	4	145	1	0	0	0	0	0	0	0	1	6791	816	29	2		2	GRAMD4	22	47033814	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	15942625	47033814	4270752	400	26820											
PLXNB2	23654	broad.mit.edu	37	chr22	50718166	50718166	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttccacctgatgtttgaTggccttgaagagcttgtaca	8	15	9	9	0	0	4	0	3	0	1	1	4	1	4	3	1	2	3	3	1	2	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:50718166T>A	uc003bkv.3	-	27	4388	c.4282A>T	c.(4282-4284)ATC>TTC	p.I1428F	PLXNB2_uc003bkt.1_Missense_Mutation_p.I220F|PLXNB2_uc003bku.1_Missense_Mutation_p.I413F	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1428	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGATGTTTGATGGCCTTGAAG	0.622													116	223					0	0	0	0	A	50718166	A	A	50718166	3	1	145	1	0	0	0	0	1	0	0	0	12179	1464	51	5	1278	5	PLXNB2	22	50718166	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	3684352	50718166	586400	401	26821											
SAPS2	9701	broad.mit.edu	37	chr22	50860746	50860746	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcatacgctgtcagcagcagCgtactacacggcatcgagcc	10	7	10	14	4	2	0	2	0	0	0	3	1	2	0	1	1	7	5	1	1	3	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:50860746C>T	uc003blb.1	+	10	1331	c.909C>T	c.(907-909)AGC>AGT	p.S303S	SAPS2_uc003bky.1_Silent_p.S303S|SAPS2_uc003bkz.1_Silent_p.S303S|SAPS2_uc003blc.2_Silent_p.S303S|SAPS2_uc003bla.1_Silent_p.S304S|uc011arw.1_5'Flank	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	303						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		TCAGCAGCAGCGTACTACACG	0.592													11	167					0	0	0	0	T	50860746	T	T	50860746	2	4	145	1	0	0	0	0	0	0	0	1	13902	767	27	1		1	SAPS2	22	50860746	Silent	SNP	C	TCGA-CR-7374-01A-11D-2012-08	142580	50860746	443820	402	26822											
TLR7	51284	broad.mit.edu	37	chrX	12904444	12904444	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccatttccttgtgcgccgTgtaaaaataattctccccta	9	13	5	14	2	1	0	0	0	1	0	3	0	2	0	6	0	1	1	6	0	5	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:12904444T>G	uc004cvc.2	+	3	956	c.817T>G	c.(817-819)TGT>GGT	p.C273G		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	273	Extracellular (Potential).|LRR 9.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	TTGTGCGCCGTGTAAAAATAA	0.388													56	70					0	0	0	0	G	12904444	G	G	12904444	3	3	145	1	0	0	0	0	1	0	0	0	16022	1696	59	5	823	5	TLR7	23	12904444	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08		12904444	142366116	403	26823											
YY2	404281	broad.mit.edu	37	chrX	21863309	21863309	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttcaattttggaatggtgtTtggcgtaattgccatgttta	8	18	11	4	1	1	0	1	0	0	0	1	1	1	1	1	3	1	4	1	3	4	8			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:21863309T>G	uc010nfq.2	+	3	442	c.245T>G	c.(244-246)TTT>TGT	p.F82C	MBTPS2_uc004dae.2_Missense_Mutation_p.F82C|MBTPS2_uc004dab.2_Missense_Mutation_p.F82C	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	Error:Variant_position_missing_in_O15391_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GGAATGGTGTTTGGCGTAATT	0.333													59	60					0	0	0	0	G	21863309	G	G	21863309	3	3	145	1	0	0	0	0	1	0	0	0	17577	1841	64	5		5	YY2	23	21863309	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	8958865	21863309	133407251	404	26824											
CXorf59	286464	broad.mit.edu	37	chrX	36162677	36162677	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggcaacgttttgtttctaGgtgtgtctgagggtgtttcc	4	17	13	7	1	2	1	0	1	2	0	3	1	3	1	1	3	1	4	1	3	2	5			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:36162677G>C	uc004ddk.1	+	11	1447	c.1261_splice	c.e11-1	p.V421_splice		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464							integral to membrane				central_nervous_system(1)	1						tttgtttctaggtgtgtctga	0.01													47	74					0	0	0	0	C	36162677	C	C	36162677	5	2	145	1	0	0	0	0	0	0	1	0	4132	1014	35	4	1298	4	CXorf59	23	36162677	Splice_Site	SNP	G	TCGA-CR-7374-01A-11D-2012-08	14299368	36162677	119107883	405	26825											
USP9X	8239	broad.mit.edu	37	chrX	41069829	41069829	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aattttttaattcattggtgGatagtttagatgaagcttta	12	19	8	2	0	1	2	1	1	0	1	1	3	1	3	0	2	1	2	0	2	6	10			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:41069829G>T	uc004dfb.2	+	33	5716	c.5083G>T	c.(5083-5085)GAT>TAT	p.D1695Y	USP9X_uc004dfc.2_Missense_Mutation_p.D1695Y	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1695					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TTCATTGGTGGATAGTTTAGA	0.388													43	36					1.22674e-20	2.07647e-20	1	0	T	41069829	T	T	41069829	3	4	145	1	0	0	0	0	1	0	0	0	17158	1174	41	2	5209	2	USP9X	23	41069829	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	4907152	41069829	114200731	406	26826											
HUWE1	10075	broad.mit.edu	37	chrX	53634558	53634558	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcaatgggcagattgggaaGacccaaaatggtaaccaaag	16	6	12	7	0	1	2	1	0	0	2	1	3	1	3	2	3	1	2	2	3	6	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:53634558G>A	uc004dsp.2	-	25	2824	c.2422C>T	c.(2422-2424)CTT>TTT	p.L808F		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	808					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGATTGGGAAGACCCAAAATG	0.438													10	92					0	0	0	0	A	53634558	A	A	53634558	3	1	145	1	0	0	0	0	1	0	0	0	7500	942	33	2	10942	2	HUWE1	23	53634558	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	12564729	53634558	101636002	407	26827											
TSR2	90121	broad.mit.edu	37	chrX	54469925	54469925	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagacgggagtctgccccagGtgagcttatcacgggcacaa	11	6	13	11	2	2	2	1	1	1	1	2	3	2	3	2	3	2	2	2	3	3	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:54469925G>T	uc004dte.2	+	3	266	c.264_splice	c.e3+1	p.Q88_splice	TSR2_uc004dtf.2_Splice_Site	NM_058163	NP_477511	Q969E8	TSR2_HUMAN	TSR2, 20S rRNA accumulation, homolog						rRNA processing		protein binding				0						TCTGCCCCAGGTGAGCTTATC	0.512													51	125					7.05377e-20	1.18279e-19	1	0	T	54469925	T	T	54469925	5	4	145	1	0	0	0	0	0	0	1	0	16732	1275	44	4	275	4	TSR2	23	54469925	Splice_Site	SNP	G	TCGA-CR-7374-01A-11D-2012-08	835367	54469925	100800635	408	26828											
FAAH2	158584	broad.mit.edu	37	chrX	57313310	57313310	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttcctcttgcgggcgctaGgctttctcataggcttagta	5	15	11	10	2	2	0	1	0	2	0	4	0	3	0	1	3	1	5	1	3	4	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:57313310G>A	uc004dvc.2	+	1	201	c.52G>A	c.(52-54)GGC>AGC	p.G18S		NM_174912	NP_777572	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	18	Helical; (Potential).					integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3						GCGGGCGCTAGGCTTTCTCAT	0.562										HNSCC(52;0.14)			8	31					0	0	0	0	A	57313310	A	A	57313310	3	1	145	1	0	0	0	0	1	0	0	0	5382	1000	35	4	54	4	FAAH2	23	57313310	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2843385	57313310	97957250	409	26829											
KIAA2022	340533	broad.mit.edu	37	chrX	73960704	73960704	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttctctccattgatggcagCcatgtatttccctttctttg	5	19	6	11	0	2	1	0	1	2	0	5	1	4	1	3	1	1	2	3	1	1	6			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:73960704C>T	uc004eby.2	-	3	4305	c.3688G>A	c.(3688-3690)GCT>ACT	p.A1230T		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1230					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTGATGGCAGCCATGTATTTC	0.473													33	85					0	0	0	0	T	73960704	T	T	73960704	3	4	145	1	0	0	0	0	1	0	0	0	8308	739	26	4	870	4	KIAA2022	23	73960704	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	16647394	73960704	81309856	410	26830											
ATRX	546	broad.mit.edu	37	chrX	76874427	76874427	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatccaagtaaattttccttGataaaattaaccatacaatg	17	13	4	7	0	0	1	0	1	0	0	2	2	2	1	3	0	2	1	3	0	8	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:76874427G>C	uc004ecp.3	-	21	5527	c.5295C>G	c.(5293-5295)ATC>ATG	p.I1765M	ATRX_uc004ecq.3_Missense_Mutation_p.I1727M|ATRX_uc004eco.3_Missense_Mutation_p.I1550M	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1765	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AATTTTCCTTGATAAAATTAA	0.313			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						8	41					0	0	0	0	C	76874427	C	C	76874427	3	2	145	1	0	0	0	0	1	0	0	0	1210	1280	45	2	2243	2	ATRX	23	76874427	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	2913723	76874427	78396133	411	26831											
PABPC5	140886	broad.mit.edu	37	chrX	90690736	90690736	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccgaatctgccgtgatccgGtgacccgcagccccctgggc	5	6	12	18	4	1	2	0	2	1	0	2	3	2	2	6	2	2	1	6	2	1	0			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:90690736G>T	uc004efg.2	+	2	600	c.160G>T	c.(160-162)GTG>TTG	p.V54L	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	54	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CCGTGATCCGGTGACCCGCAG	0.537													14	17					1.36491e-13	2.1912e-13	1	0	T	90690736	T	T	90690736	3	4	145	1	0	0	0	0	1	0	0	0	11421	1261	44	4	162	4	PABPC5	23	90690736	Missense_Mutation	SNP	G	TCGA-CR-7374-01A-11D-2012-08	13816309	90690736	64579824	412	26832											
TNMD	64102	broad.mit.edu	37	chrX	99854535	99854535	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatagaatttgatcccatgCtggatgagagaggttattgt	12	13	12	4	0	0	4	0	2	0	2	1	7	1	5	1	2	1	2	1	2	4	4			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:99854535C>A	uc004efy.3	+	7	1001	c.775C>A	c.(775-777)CTG>ATG	p.L259M	TNMD_uc004efz.2_3'UTR	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	259	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						TGATCCCATGCTGGATGAGAG	0.478													17	10					3.41278e-10	5.35867e-10	1	0	A	99854535	A	A	99854535	3	1	145	1	0	0	0	0	1	0	0	0	16388	796	28	4	801	4	TNMD	23	99854535	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	9163799	99854535	55416025	413	26833											
ZMAT1	84460	broad.mit.edu	37	chrX	101139207	101139207	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctgcacttttatgtaatCttcaagttcatcttggaaag	10	18	6	7	0	5	0	2	0	3	0	5	1	5	1	0	1	1	3	0	1	4	7			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:101139207C>G	uc004eim.2	-	2	4177	c.679G>C	c.(679-681)GAT>CAT	p.D227H	ZMAT1_uc011mrl.1_Missense_Mutation_p.D398H|ZMAT1_uc004ein.2_Missense_Mutation_p.D227H|ZMAT1_uc011mrm.1_Missense_Mutation_p.D227H	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	227						nucleus	zinc ion binding			ovary(1)	1						TTTATGTAATCTTCAAGTTCA	0.413													14	310					0	0	0	0	G	101139207	G	G	101139207	3	3	145	1	0	0	0	0	1	0	0	0	17758	913	32	2	728	2	ZMAT1	23	101139207	Missense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	1284672	101139207	54131353	414	26834											
GRIA3	2892	broad.mit.edu	37	chrX	122318400	122318400	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcgtacatggccaggcagAagaaaatggggcaaagcgtg	14	4	16	7	2	0	2	0	0	0	2	0	2	0	2	1	5	2	3	1	5	5	1			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:122318400A>G	uc004etq.3	+	2	306	c.13A>G	c.(13-15)AAG>GAG	p.K5E	GRIA3_uc004etr.3_Missense_Mutation_p.K5E|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_5'Flank|GRIA3_uc010nqs.1_Missense_Mutation_p.K5E	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	5					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	GGCCAGGCAGAAGAAAATGGG	0.483													94	97					0	0	0	0	G	122318400	G	G	122318400	3	3	145	1	0	0	0	0	1	0	0	0	6808	247	9	5	15	5	GRIA3	23	122318400	Missense_Mutation	SNP	A	TCGA-CR-7374-01A-11D-2012-08	21179193	122318400	32952160	415	26835											
SLITRK2	84631	broad.mit.edu	37	chrX	144906314	144906314	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgccccttcctatgaatctCgacgccaaaaccaagacaga	13	8	6	14	2	1	3	0	1	1	2	3	4	2	3	5	0	2	0	5	0	5	3			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:144906314C>T	uc004fcd.2	+	5	3361	c.2371C>T	c.(2371-2373)CGA>TGA	p.R791*	SLITRK2_uc010nsp.2_Nonsense_Mutation_p.R791*|SLITRK2_uc010nso.2_Nonsense_Mutation_p.R791*|SLITRK2_uc011mwq.1_Nonsense_Mutation_p.R791*|SLITRK2_uc011mwr.1_Nonsense_Mutation_p.R791*|SLITRK2_uc011mws.1_Nonsense_Mutation_p.R791*|SLITRK2_uc004fcg.2_Nonsense_Mutation_p.R791*|SLITRK2_uc011mwt.1_Nonsense_Mutation_p.R791*|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	791	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CTATGAATCTCGACGCCAAAA	0.453													98	109					0	0	0	0	T	144906314	T	T	144906314	4	4	145	1	0	0	0	0	0	1	0	0	14807	876	31	1	2373	1	SLITRK2	23	144906314	Nonsense_Mutation	SNP	C	TCGA-CR-7374-01A-11D-2012-08	22587914	144906314	10364246	416	26836											
FLNA	2316	broad.mit.edu	37	chrX	153594777	153594777	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctggcgtcaccctgtgacTtatccacgtacacctcgaag	8	10	9	14	3	1	1	1	1	0	0	3	2	2	1	3	1	2	2	3	1	3	2			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:153594777T>A	uc004fkk.2	-	8	1376	c.1127A>T	c.(1126-1128)AAG>ATG	p.K376M	FLNA_uc010nuu.1_Missense_Mutation_p.K376M	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	376	Filamin 2.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCCTGTGACTTATCCACGTA	0.597													13	73					0	0	0	0	A	153594777	A	A	153594777	3	1	145	1	0	0	0	0	1	0	0	0	5965	1609	56	5	6980	5	FLNA	23	153594777	Missense_Mutation	SNP	T	TCGA-CR-7374-01A-11D-2012-08	8688463	153594777	1675783	417	26837											
PRAMEF2	65122	broad.mit.edu	37	chr1	12920037	12920037	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatggttagtcaccagattCacctctgtgttcctcaggct	7	13	10	11	0	4	1	3	0	1	1	5	2	5	2	3	3	0	3	3	3	1	3			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr1:12920037C>T	uc001aum.1	+	3	864	c.777C>T	c.(775-777)TTC>TTT	p.F259F		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	259											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCACCAGATTCACCTCTGTGT	0.458													10	125					0	0	0	0	T	12920037	T	T	12920037	2	4	146	1	0	0	0	0	0	0	0	1	12495	825	29	2		2	PRAMEF2	1	12920037	Silent	SNP	C	TCGA-CR-7376-01A-11D-2129-08		12920037	236330584	1	26838											
MPL	4352	broad.mit.edu	37	chr1	43812539	43812539	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggagtggcagcacccatcGtcctgggcagcccaagagac	9	6	13	13	1	0	1	0	0	0	1	2	3	1	2	3	3	2	3	3	3	1	1			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr1:43812539G>A	uc001ciw.2	+	8	1287	c.1242G>A	c.(1240-1242)TCG>TCA	p.S414S	MPL_uc001civ.2_Silent_p.S414S|MPL_uc009vwr.2_Silent_p.S407S	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	414	Fibronectin type-III 2.|Extracellular (Potential).				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGCACCCATCGTCCTGGGCAG	0.567			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						10	69					0	0	0	0	A	43812539	A	A	43812539	2	1	146	1	0	0	0	0	0	0	0	1	9783	1132	40	1		1	MPL	1	43812539	Silent	SNP	G	TCGA-CR-7376-01A-11D-2129-08	30892502	43812539	205438082	2	26839											
KIAA0494	9813	broad.mit.edu	37	chr1	47148983	47148983	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaatttaccttcagtgctaGaaactcctggtagggagata	14	11	9	7	0	1	2	1	0	0	2	2	3	2	2	2	2	3	2	2	2	7	6			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr1:47148983G>C	uc001cqk.3	-	10	2278	c.1301C>G	c.(1300-1302)TCT>TGT	p.S434C	KIAA0494_uc010omh.1_Missense_Mutation_p.S370C|KIAA0494_uc010omj.1_Missense_Mutation_p.S226C	NM_014774	NP_055589	O75071	K0494_HUMAN	hypothetical protein LOC9813	434	EF-hand 1.						calcium ion binding				0	Acute lymphoblastic leukemia(166;0.155)					TTCAGTGCTAGAAACTCCTGG	0.358													9	126					0	0	0	0	C	47148983	C	C	47148983	3	2	146	1	0	0	0	0	1	0	0	0	8218	942	33	2	194	2	KIAA0494	1	47148983	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	3336444	47148983	202101638	3	26840											
PXDN	7837	broad.mit.edu	37	chr2	1652027	1652027	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccgccgatagattgcagtaGaccctgtagtcgtggtaggg	8	9	15	9	3	0	2	0	0	0	2	1	3	0	2	3	2	1	4	3	2	4	5			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr2:1652027G>C	uc002qxa.2	-	17	3589	c.3525C>G	c.(3523-3525)GTC>GTG	p.V1175V		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1175					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GATTGCAGTAGACCCTGTAGT	0.572													16	166					0	0	0	0	C	1652027	C	C	1652027	2	2	146	1	0	0	0	0	0	0	0	1	12912	929	33	2		2	PXDN	2	1652027	Silent	SNP	G	TCGA-CR-7376-01A-11D-2129-08		1652027	241547346	4	26841											
GREB1	9687	broad.mit.edu	37	chr2	11767109	11767109	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagggatgtcccggaagcCggaggacctttatgtgcggc	8	7	16	10	3	0	1	0	0	0	1	1	5	1	5	3	5	2	0	3	5	2	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr2:11767109C>T	uc002rbk.1	+	25	4628	c.4328C>T	c.(4327-4329)CCG>CTG	p.P1443L	GREB1_uc002rbp.1_Missense_Mutation_p.P441L	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1443						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TCCCGGAAGCCGGAGGACCTT	0.532													4	65					0	0	0	0	T	11767109	T	T	11767109	3	4	146	1	0	0	0	0	1	0	0	0	6799	652	23	1	4530	1	GREB1	2	11767109	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	10115082	11767109	231432264	5	26842											
TTN	7273	broad.mit.edu	37	chr2	179439605	179439605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtacaccaccatcgttctCaggtgggtcccaagagaagg	10	8	12	11	1	1	1	1	0	1	1	4	2	2	1	3	4	1	2	3	4	3	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr2:179439605C>T	uc010zfg.1	-	275	63774	c.63550G>A	c.(63550-63552)GAG>AAG	p.E21184K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E14879K|TTN_uc010zfi.1_Missense_Mutation_p.E14812K|TTN_uc010zfj.1_Missense_Mutation_p.E14687K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22111							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATCGTTCTCAGGTGGGTCC	0.453													5	21					0	0	0	0	T	179439605	T	T	179439605	3	4	146	1	0	0	0	0	1	0	0	0	16803	835	29	2	36873	2	TTN	2	179439605	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	167672496	179439605	63759768	6	26843											
ERBB4	2066	broad.mit.edu	37	chr2	212587119	212587119	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttattctgttacttacgTggacatttcttgacacagaa	10	17	6	8	1	3	2	0	1	3	1	3	3	3	3	0	1	2	1	0	1	4	7	rs77309171	byFrequency	TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr2:212587119T>C	uc002veg.1	-	7	980	c.882A>G	c.(880-882)CCA>CCG	p.P294P	ERBB4_uc002veh.1_Silent_p.P294P|ERBB4_uc010zji.1_Silent_p.P294P|ERBB4_uc010zjj.1_Silent_p.P294P|ERBB4_uc010fut.1_Silent_p.P294P	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	294	Cys-rich.|Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTTACTTACGTGGACATTTCT	0.313										TSP Lung(8;0.080)			3	46					0	0	0	0	C	212587119	C	C	212587119	2	2	146	1	0	0	0	0	0	0	0	1	5233	1710	59	5		5	ERBB4	2	212587119	Silent	SNP	T	TCGA-CR-7376-01A-11D-2129-08	33147514	212587119	30612254	7	26844											
ATG7	10533	broad.mit.edu	37	chr3	11389503	11389503	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggctccagaaaatattcccCggtgtggtatgttgttgctt	7	14	11	9	2	0	1	0	0	0	1	2	1	2	1	3	3	1	5	3	3	4	6			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr3:11389503C>T	uc003bwc.2	+	12	1395	c.1278C>T	c.(1276-1278)CCC>CCT	p.P426P	ATG7_uc003bwd.2_Silent_p.P426P|ATG7_uc011aum.1_Silent_p.P387P	NM_006395	NP_006386	O95352	ATG7_HUMAN	APG7 autophagy 7-like isoform a	426					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)	1						AAATATTCCCCGGTGTGGTAT	0.478													8	123					0	0	0	0	T	11389503	T	T	11389503	2	4	146	1	0	0	0	0	0	0	0	1	1103	639	23	1		1	ATG7	3	11389503	Silent	SNP	C	TCGA-CR-7376-01A-11D-2129-08		11389503	186632927	8	26845											
TGFBR2	7048	broad.mit.edu	37	chr3	30713559	30713559	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacagagaaggacatcttctCagacatcaatctgaagcatg	15	8	9	9	0	4	3	2	1	3	2	5	6	4	4	0	1	1	1	0	1	3	1			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr3:30713559C>G	uc003ceo.2	+	4	1266	c.884C>G	c.(883-885)TCA>TGA	p.S295*	TGFBR2_uc003cen.2_Nonsense_Mutation_p.S320*	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	295	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						GACATCTTCTCAGACATCAAT	0.493													9	77					0	0	0	0	G	30713559	G	G	30713559	4	3	146	1	0	0	0	0	0	1	0	0	15888	838	29	2	977	2	TGFBR2	3	30713559	Nonsense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	19324056	30713559	167308871	9	26846											
SLC22A14	9389	broad.mit.edu	37	chr3	38347718	38347718	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtttggcacattccagcaGaggctagtagccctcacctt	9	10	10	12	0	1	1	1	0	0	1	2	2	2	1	3	2	2	5	3	2	2	5			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr3:38347718G>C	uc010hhc.1	+	2	243	c.201G>C	c.(199-201)CAG>CAC	p.Q67H	SLC22A14_uc003cia.2_Missense_Mutation_p.Q67H|SLC22A14_uc003cib.2_Missense_Mutation_p.Q67H|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	67	Cytoplasmic (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		CATTCCAGCAGAGGCTAGTAG	0.532													10	85					0	0	0	0	C	38347718	C	C	38347718	3	2	146	1	0	0	0	0	1	0	0	0	14510	933	33	2	203	2	SLC22A14	3	38347718	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	7634159	38347718	159674712	10	26847											
ACOX2	8309	broad.mit.edu	37	chr3	58514635	58514635	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgatggccagctgaggaaaGagtttctgctgttgtgtctg	7	13	14	7	0	2	3	0	2	2	1	2	4	2	4	1	2	2	4	1	2	1	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr3:58514635G>C	uc003dkl.2	-	9	1216	c.1041C>G	c.(1039-1041)CTC>CTG	p.L347L		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	acyl-Coenzyme A oxidase 2	347					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		GCTGAGGAAAGAGTTTCTGCT	0.463													8	77					0	0	0	0	C	58514635	C	C	58514635	2	2	146	1	0	0	0	0	0	0	0	1	159	929	33	2		2	ACOX2	3	58514635	Silent	SNP	G	TCGA-CR-7376-01A-11D-2129-08	20166917	58514635	139507795	11	26848											
GPR15	2838	broad.mit.edu	37	chr3	98251012	98251012	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttacacagctgtgttcctGactggagtgctggggaacct	7	13	12	9	0	0	1	0	1	0	0	1	3	1	3	2	3	4	3	2	3	2	3			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr3:98251012G>T	uc011bgy.1	+	1	135	c.135G>T	c.(133-135)CTG>CTT	p.L45L		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	45	Helical; Name=1; (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		CTGTGTTCCTGACTGGAGTGC	0.502													7	68					8.12818e-05	8.941e-05	1	0	T	98251012	T	T	98251012	2	4	146	1	0	0	0	0	0	0	0	1	6693	1277	45	2		2	GPR15	3	98251012	Silent	SNP	G	TCGA-CR-7376-01A-11D-2129-08	39736377	98251012	99771418	12	26849											
H1FX	8971	broad.mit.edu	37	chr3	129034495	129034495	+	Frame_Shift_Del	DEL	T	-	-																															acttgaggtaggtgcgcccaTtctgctggtcgaaccacgga																										TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr3:129034495delT	uc003elx.2	-	1	626	c.251delA	c.(250-252)AATfs	p.N84fs	C3orf47_uc011bkv.1_5'Flank	NM_006026	NP_006017	Q92522	H1X_HUMAN	H1 histone family, member X	84	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding				0						GGTGCGCCCATTCTGCTGGTC	0.612													---	---	---								-	129034495	-	-	129034495	7	5	146	1	0	1	0	1	0	0	0	0	6962	1493	52	0	394	0	H1FX	3	129034495	Frame_Shift_Del	DEL	T	TCGA-CR-7376-01A-11D-2129-08	30783483	129034495	68987935	13	26850											
SLC34A2	10568	broad.mit.edu	37	chr4	25667818	25667818	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttgttggggctggtgatcGgggtgctggtgaccgtcttg	2	14	18	7	2	1	2	0	2	1	0	2	2	1	2	1	6	1	3	1	6	0	3			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr4:25667818G>A	uc003grr.2	+	5	529	c.448G>A	c.(448-450)GGG>AGG	p.G150R	SLC34A2_uc003grs.2_Missense_Mutation_p.G149R|SLC34A2_uc010iev.2_Missense_Mutation_p.G149R	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	150	Helical; Name=M2; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GCTGGTGATCGGGGTGCTGGT	0.507													6	100					0	0	0	0	A	25667818	A	A	25667818	3	1	146	1	0	0	0	0	1	0	0	0	14632	1116	39	1	462	1	SLC34A2	4	25667818	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08		25667818	165486458	14	26851											
FAT4	79633	broad.mit.edu	37	chr4	126412367	126412367	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagtggagaggctcaacaCacctcgccctagaaacccaa	15	4	9	13	1	1	3	1	0	0	3	2	4	1	3	3	2	2	1	3	2	5	1			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr4:126412367C>A	uc003ifj.3	+	17	14390	c.14390C>A	c.(14389-14391)ACA>AAA	p.T4797K	FAT4_uc011cgp.1_Missense_Mutation_p.T3038K|FAT4_uc003ifi.1_Missense_Mutation_p.T2274K	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4797	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGGCTCAACACACCTCGCCCT	0.527													6	71					3.59834e-05	4.04813e-05	1	0	A	126412367	A	A	126412367	3	1	146	1	0	0	0	0	1	0	0	0	5724	478	17	4	14456	4	FAT4	4	126412367	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	100744549	126412367	64741909	15	26852											
TRIO	7204	broad.mit.edu	37	chr5	14504668	14504668	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcggcctcctcgacacctttGagacccccaccagctacatc	8	8	6	19	2	0	1	0	1	0	1	4	3	1	1	6	1	2	1	6	1	1	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr5:14504668G>C	uc003jff.2	+	55	8584	c.8578G>C	c.(8578-8580)GAG>CAG	p.E2860Q	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2860	Protein kinase.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CGACACCTTTGAGACCCCCAC	0.582													8	228					0	0	0	0	C	14504668	C	C	14504668	3	2	146	1	0	0	0	0	1	0	0	0	16619	1291	45	2	8796	2	TRIO	5	14504668	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08		14504668	166410592	16	26853											
SLC4A9	83697	broad.mit.edu	37	chr5	139747331	139747331	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctggcttccacctggacctCttctgtgtggctgtgctgat	3	14	12	12	0	2	1	0	1	2	0	3	2	3	2	3	3	1	4	3	3	0	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr5:139747331C>G	uc003lfm.2	+	16	2309	c.2274C>G	c.(2272-2274)CTC>CTG	p.L758L	SLC4A9_uc003lfj.2_Silent_p.L734L|SLC4A9_uc011czg.1_Silent_p.L671L|SLC4A9_uc003lfl.2_Silent_p.L734L|SLC4A9_uc003lfk.2_Silent_p.L720L	NM_031467	NP_113655	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate	758	Helical; (Potential).|Membrane (anion exchange).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTGGACCTCTTCTGTGTGG	0.582													4	38					0	0	0	0	G	139747331	G	G	139747331	2	3	146	1	0	0	0	0	0	0	0	1	14724	900	32	2		2	SLC4A9	5	139747331	Silent	SNP	C	TCGA-CR-7376-01A-11D-2129-08	125242663	139747331	41167929	17	26854											
PCDHGA12	26025	broad.mit.edu	37	chr5	140812277	140812277	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccgtccaggaccacggcCagccccctctctccgccact	5	6	9	21	3	1	0	0	0	1	0	4	1	3	1	8	3	1	0	8	3	0	0			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr5:140812277C>A	uc003lkt.1	+	1	2120	c.1951C>A	c.(1951-1953)CAG>AAG	p.Q651K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.Q651K	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	651	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACCACGGCCAGCCCCCTCT	0.697													10	121					6.40141e-05	7.12067e-05	1	0	A	140812277	A	A	140812277	3	1	146	1	0	0	0	0	1	0	0	0	11607	595	21	4	1953	4	PCDHGA12	5	140812277	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	1064946	140812277	40102983	18	26855											
OR2J2	26707	broad.mit.edu	37	chr6	29141890	29141890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttttactatctcagcacttCattcctcctttactttctgg	6	19	4	12	0	3	0	2	0	2	0	6	0	5	0	2	1	3	2	2	1	3	8			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr6:29141890C>T	uc011dlm.1	+	1	580	c.478C>T	c.(478-480)CAT>TAT	p.H160Y		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	160	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTCAGCACTTCATTCCTCCTT	0.463													19	250					0	0	0	0	T	29141890	T	T	29141890	3	4	146	1	0	0	0	0	1	0	0	0	11057	826	29	2	480	2	OR2J2	6	29141890	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08		29141890	141973177	19	26856											
TDRD6	221400	broad.mit.edu	37	chr6	46658969	46658969	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttaaaaacatctcccttgaAccctggaaccttgtgccttg	10	13	6	12	0	1	1	0	1	1	0	2	2	1	2	4	1	4	0	4	1	5	5			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr6:46658969A>G	uc003oyj.2	+	1	3104	c.3104A>G	c.(3103-3105)AAC>AGC	p.N1035S	TDRD6_uc010jze.2_Missense_Mutation_p.N1029S	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1035	Tudor 5.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TCTCCCTTGAACCCTGGAACC	0.368													4	83					0	0	0	0	G	46658969	G	G	46658969	3	3	146	1	0	0	0	0	1	0	0	0	15800	43	2	5	3106	5	TDRD6	6	46658969	Missense_Mutation	SNP	A	TCGA-CR-7376-01A-11D-2129-08	17517079	46658969	124456098	20	26857											
AIM1	202	broad.mit.edu	37	chr6	106967352	106967352	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaaccaaagttaccgtctcgGaagaagagattctgccagca	15	7	9	10	2	2	2	0	0	2	2	3	4	2	3	3	1	4	2	3	1	5	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr6:106967352G>A	uc003prh.2	+	2	1532	c.1045G>A	c.(1045-1047)GAA>AAA	p.E349K		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	349							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TACCGTCTCGGAAGAAGAGAT	0.438													8	67					0	0	0	0	A	106967352	A	A	106967352	3	1	146	1	0	0	0	0	1	0	0	0	430	1175	41	2	1051	2	AIM1	6	106967352	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	60308383	106967352	64147715	21	26858											
MYO1G	64005	broad.mit.edu	37	chr7	45010270	45010270	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccatcacgccgaggatcccGgccccggggttccatgacac	7	5	12	17	4	1	1	1	1	0	0	3	3	3	2	6	4	0	1	6	4	0	1			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr7:45010270G>A	uc003tmh.2	-	9	1282	c.1138C>T	c.(1138-1140)CGG>TGG	p.R380W	MYO1G_uc003tmf.2_5'Flank|MYO1G_uc003tmg.2_Missense_Mutation_p.R142W|MYO1G_uc010kym.2_Missense_Mutation_p.R265W|MYO1G_uc003tmi.1_Missense_Mutation_p.R292W|MYO1G_uc003tmj.2_Missense_Mutation_p.R142W	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	380	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						CGAGGATCCCGGCCCCGGGGT	0.602													12	118					0	0	0	0	A	45010270	A	A	45010270	3	1	146	1	0	0	0	0	1	0	0	0	10127	1115	39	1	1974	1	MYO1G	7	45010270	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08		45010270	114128393	22	26859											
SUMF2	25870	broad.mit.edu	37	chr7	56136270	56136270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagatggtgacgggcctgtgCgggaggcgacagtgaaaccc	9	5	18	9	3	0	3	0	2	0	1	0	6	0	4	2	4	2	0	2	4	1	0	rs150976522	byFrequency	TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr7:56136270C>T	uc003trv.2	+	2	251	c.220C>T	c.(220-222)CGG>TGG	p.R74W	PSPH_uc003trj.2_Intron|SUMF2_uc003tro.2_Missense_Mutation_p.R74W|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_Missense_Mutation_p.R74W|SUMF2_uc011kcx.1_Missense_Mutation_p.R74W|SUMF2_uc003trt.2_Intron|SUMF2_uc011kcy.1_Missense_Mutation_p.R74W|SUMF2_uc011kcz.1_Missense_Mutation_p.R74W|SUMF2_uc003tru.2_RNA|SUMF2_uc011kda.1_5'UTR|SUMF2_uc003trx.2_RNA	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	55						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CGGGCCTGTGCGGGAGGCGAC	0.507													4	46					0	0	0	0	T	56136270	T	T	56136270	3	4	146	1	0	0	0	0	1	0	0	0	15452	759	27	1	226	1	SUMF2	7	56136270	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	11126000	56136270	103002393	23	26860											
RABGEF1	27342	broad.mit.edu	37	chr7	66262383	66262383	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctccagaaagagtcgagaaGataatggatcagattgaaaa	18	7	10	6	1	1	6	1	1	0	5	3	8	2	7	2	1	0	0	2	1	5	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr7:66262383G>C	uc011kee.1	+	6	824	c.660G>C	c.(658-660)AAG>AAC	p.K220N	RABGEF1_uc003tvf.2_Missense_Mutation_p.K79N|RABGEF1_uc003tvg.2_Missense_Mutation_p.K14N|RABGEF1_uc010lag.2_Missense_Mutation_p.K206N|RABGEF1_uc003tvh.2_Missense_Mutation_p.K206N|RABGEF1_uc003tvi.2_Missense_Mutation_p.K40N	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	423					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						GAGTCGAGAAGATAATGGATC	0.279													4	46					0	0	0	0	C	66262383	C	C	66262383	3	2	146	1	0	0	0	0	1	0	0	0	13031	933	33	2	636	2	RABGEF1	7	66262383	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	10126113	66262383	92876280	24	26861											
AKAP9	10142	broad.mit.edu	37	chr7	91682106	91682106	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgacattaacatgtggtCaaaagtaactgaggaaggaa	19	8	10	4	0	1	2	1	2	0	0	1	4	1	4	0	3	2	1	0	3	7	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr7:91682106C>G	uc003ulg.2	+	22	5660	c.5435C>G	c.(5434-5436)TCA>TGA	p.S1812*	AKAP9_uc003ulf.2_Nonsense_Mutation_p.S1812*|AKAP9_uc003uli.2_Nonsense_Mutation_p.S1435*	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1824					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AACATGTGGTCAAAAGTAACT	0.373			T	BRAF	papillary thyroid								9	61					0	0	0	0	G	91682106	G	G	91682106	4	3	146	1	0	0	0	0	0	1	0	0	459	838	29	2	5521	2	AKAP9	7	91682106	Nonsense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	25419723	91682106	67456557	25	26862											
PCOLCE	5118	broad.mit.edu	37	chr7	100205594	100205594	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgatgggccaggtagaagaGaacagaggccccgtccttcc	10	6	13	12	1	0	4	0	1	0	3	2	5	2	4	5	3	1	1	5	3	3	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr7:100205594G>A	uc003uvo.2	+	9	1416	c.1218G>A	c.(1216-1218)GAG>GAA	p.E406E	PCOLCE_uc010lhb.1_RNA|PCOLCE_uc003uvp.1_RNA	NM_002593	NP_002584	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	406	NTR.				multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity				0	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					AGGTAGAAGAGAACAGAGGCC	0.547													12	105					0	0	0	0	A	100205594	A	A	100205594	2	1	146	1	0	0	0	0	0	0	0	1	11648	933	33	2		2	PCOLCE	7	100205594	Silent	SNP	G	TCGA-CR-7376-01A-11D-2129-08	8523488	100205594	58933069	26	26863											
MUC17	140453	broad.mit.edu	37	chr7	100685103	100685103	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgcctctcagtaccacgcCggtggccagttctgaggcta	7	10	11	13	2	2	1	1	1	2	0	3	1	2	1	4	3	2	3	4	3	3	4	rs146748610	byFrequency	TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr7:100685103C>T	uc003uxp.1	+	3	10459	c.10406C>T	c.(10405-10407)CCG>CTG	p.P3469L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3469	Extracellular (Potential).|Ser-rich.|56.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGTACCACGCCGGTGGCCAGT	0.498													33	350					0	0	0	0	T	100685103	T	T	100685103	3	4	146	1	0	0	0	0	1	0	0	0	10027	652	23	1	10416	1	MUC17	7	100685103	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	479509	100685103	58453560	27	26864											
PIK3CG	5294	broad.mit.edu	37	chr7	106520087	106520087	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaaacatggtgatgatctgCgccaagacatgcttatttta	12	14	8	7	1	1	3	0	2	1	1	1	3	1	3	1	1	3	1	1	1	5	4			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr7:106520087C>T	uc003vdv.3	+	6	2600	c.2515C>T	c.(2515-2517)CGC>TGC	p.R839C	PIK3CG_uc003vdu.2_Missense_Mutation_p.R839C|PIK3CG_uc003vdw.2_Missense_Mutation_p.R839C	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	839	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding	p.R839C(1)		lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TGATGATCTGCGCCAAGACAT	0.333													6	67					0	0	0	0	T	106520087	T	T	106520087	3	4	146	1	0	0	0	0	1	0	0	0	11971	768	27	1	2533	1	PIK3CG	7	106520087	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	5834984	106520087	52618576	28	26865											
LAMB1	3912	broad.mit.edu	37	chr7	107572693	107572693	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccatggctttctgccaggCgttgtgtgcaacagtaacca	8	11	11	11	1	1	0	0	0	1	0	2	0	2	0	3	2	4	4	3	2	2	3			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr7:107572693C>T	uc003vew.2	-	28	4653	c.4318G>A	c.(4318-4320)GCC>ACC	p.A1440T	LAMB1_uc003vev.2_Missense_Mutation_p.A1464T|LAMB1_uc003veu.2_5'Flank	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1440	Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCTGCCAGGCGTTGTGTGCA	0.552													19	179					0	0	0	0	T	107572693	T	T	107572693	3	4	146	1	0	0	0	0	1	0	0	0	8650	768	27	1	1070	1	LAMB1	7	107572693	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	1052606	107572693	51565970	29	26866											
OR6B1	135946	broad.mit.edu	37	chr7	143701885	143701885	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacctcgagttatccatgccTtcaacatgaacaaaattatt	14	12	5	10	1	1	1	1	1	0	0	3	3	2	1	3	0	3	1	3	0	6	4			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr7:143701885T>G	uc003wdt.1	+	1	796	c.796T>G	c.(796-798)TTC>GTC	p.F266V		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					TATCCATGCCTTCAACATGAA	0.428													8	90					0	0	0	0	G	143701885	G	G	143701885	3	3	146	1	0	0	0	0	1	0	0	0	11241	1609	56	5	798	5	OR6B1	7	143701885	Missense_Mutation	SNP	T	TCGA-CR-7376-01A-11D-2129-08	36129192	143701885	15436778	30	26867											
PRKAG2	51422	broad.mit.edu	37	chr7	151573605	151573605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactcaccggaatgtgcacgCgcagcgaacgcctcttctgg	8	7	12	14	5	3	0	1	0	2	0	3	3	3	1	2	2	3	2	2	2	2	1			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr7:151573605C>T	uc003wkk.2	-	1	712	c.101G>A	c.(100-102)CGC>CAC	p.R34H	PRKAG2_uc010lqe.1_RNA|PRKAG2_uc003wkm.1_Missense_Mutation_p.R34H|uc003wko.1_5'Flank	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	34					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		AATGTGCACGCGCAGCGAACG	0.647													7	68					0	0	0	0	T	151573605	T	T	151573605	3	4	146	1	0	0	0	0	1	0	0	0	12563	768	27	1	1672	1	PRKAG2	7	151573605	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	7871720	151573605	7565058	31	26868											
PREX2	80243	broad.mit.edu	37	chr8	69005941	69005941	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgaagcaggggatgctttTgactgtaaagtagaaggtag	13	10	15	3	0	0	3	0	2	0	1	0	5	0	4	0	3	2	5	0	3	6	5			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr8:69005941T>C	uc003xxv.1	+	21	2379	c.2352T>C	c.(2350-2352)TTT>TTC	p.F784F	PREX2_uc003xxu.1_Silent_p.F784F|PREX2_uc011lez.1_Silent_p.F719F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	784					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GGGATGCTTTTGACTGTAAAG	0.403													9	102					0	0	0	0	C	69005941	C	C	69005941	2	2	146	1	0	0	0	0	0	0	0	1	12539	1809	63	5		5	PREX2	8	69005941	Silent	SNP	T	TCGA-CR-7376-01A-11D-2129-08		69005941	77358081	32	26869											
C8orf34	116328	broad.mit.edu	37	chr8	69358591	69358591	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaacaagaagggatttcaGaagctatgataaaccttggc	16	8	11	6	0	1	3	1	1	0	2	1	5	1	5	1	3	3	1	1	3	7	4			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr8:69358591G>A	uc010lyz.2	+	3	294	c.245G>A	c.(244-246)AGA>AAA	p.R82K	C8orf34_uc010lyx.1_Missense_Mutation_p.R82K|C8orf34_uc010lyy.1_Missense_Mutation_p.R82K|C8orf34_uc003xyb.2_Missense_Mutation_p.R57K	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	82					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			AGGGATTTCAGAAGCTATGAT	0.348													4	58					0	0	0	0	A	69358591	A	A	69358591	3	1	146	1	0	0	0	0	1	0	0	0	2434	942	33	2	176	2	C8orf34	8	69358591	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	352650	69358591	77005431	33	26870											
RSPO2	340419	broad.mit.edu	37	chr8	109001316	109001316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcatatctggggctcggtgtCcatagtacccggatgggcag	7	10	14	10	2	2	0	1	0	1	0	4	1	3	1	2	5	1	3	2	5	3	3			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr8:109001316C>T	uc003yms.2	-	3	909	c.251G>A	c.(250-252)GGA>GAA	p.G84E	RSPO2_uc003ymq.2_Missense_Mutation_p.G17E|RSPO2_uc003ymr.2_Intron	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	84					Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			GGCTCGGTGTCCATAGTACCC	0.488													4	78					0	0	0	0	T	109001316	T	T	109001316	3	4	146	1	0	0	0	0	1	0	0	0	13775	855	30	2	496	2	RSPO2	8	109001316	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	39642725	109001316	37362706	34	26871											
CSMD3	114788	broad.mit.edu	37	chr8	113308235	113308235	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggaattccacaatgacccGctgaaatacgttataaagta	15	10	7	9	2	0	2	0	2	0	0	1	3	1	3	2	1	1	3	2	1	8	5			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr8:113308235G>A	uc003ynu.2	-	54	8600	c.8441C>T	c.(8440-8442)GCG>GTG	p.A2814V	CSMD3_uc003yns.2_Missense_Mutation_p.A2016V|CSMD3_uc003ynt.2_Missense_Mutation_p.A2774V|CSMD3_uc011lhx.1_Missense_Mutation_p.A2645V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2814	Extracellular (Potential).|Sushi 17.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACAATGACCCGCTGAAATACG	0.299										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	35					0	0	0	0	A	113308235	A	A	113308235	3	1	146	1	0	0	0	0	1	0	0	0	3963	1101	38	1	2754	1	CSMD3	8	113308235	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	4306919	113308235	33055787	35	26872											
GNE	10020	broad.mit.edu	37	chr9	36236908	36236908	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatgttaattcaaacattttTatggaatgcttaatgtcagt	14	17	6	4	0	2	0	2	0	0	0	2	1	2	1	0	1	2	2	0	1	6	6			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr9:36236908T>A	uc010mlh.2	-	4	905	c.690A>T	c.(688-690)ATA>ATT	p.I230I	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Silent_p.I230I|GNE_uc011lpl.1_Intron|GNE_uc010mli.2_Silent_p.I261I|GNE_uc010mlj.2_Silent_p.I225I	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	230	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			CAAACATTTTTATGGAATGCT	0.348													6	70					0	0	0	0	A	36236908	A	A	36236908	2	1	146	1	0	0	0	0	0	0	0	1	6559	1744	61	5		5	GNE	9	36236908	Silent	SNP	T	TCGA-CR-7376-01A-11D-2129-08		36236908	104976523	36	26873											
NOTCH1	4851	broad.mit.edu	37	chr9	139411828	139411828	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgttgacctcgcagtgcacaCcctcgtagcctgtggggtgg	5	10	14	12	2	0	1	0	1	0	0	2	1	0	1	3	3	2	4	3	3	1	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr9:139411828C>A	uc004chz.2	-	9	1451	c.1451G>T	c.(1450-1452)GGT>GTT	p.G484V		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	484	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.G484V(2)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCAGTGCACACCCTCGTAGCC	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			3	16					0.004672	0.00502748	1	0	A	139411828	A	A	139411828	3	1	146	1	0	0	0	0	1	0	0	0	10601	507	18	4	6320	4	NOTCH1	9	139411828	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	103174920	139411828	1801603	37	26874											
ARMC4	55130	broad.mit.edu	37	chr10	28228887	28228887	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcactatttaggttcttgAcaaggttttcaatgatcctt	9	18	6	8	0	3	2	2	2	2	0	5	2	4	2	1	2	0	2	1	2	4	8			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr10:28228887A>G	uc009xky.2	-	14	2134	c.2036T>C	c.(2035-2037)GTC>GCC	p.V679A	ARMC4_uc010qds.1_Missense_Mutation_p.V204A|ARMC4_uc010qdt.1_Missense_Mutation_p.V371A|ARMC4_uc001itz.2_Missense_Mutation_p.V679A	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	679	ARM 4.|HEAT.						binding			ovary(4)|skin(2)	6						TAGGTTCTTGACAAGGTTTTC	0.433													5	58					0	0	0	0	G	28228887	G	G	28228887	3	3	146	1	0	0	0	0	1	0	0	0	955	275	10	5	1126	5	ARMC4	10	28228887	Missense_Mutation	SNP	A	TCGA-CR-7376-01A-11D-2129-08		28228887	107305860	38	26875											
MTPAP	55149	broad.mit.edu	37	chr10	30630542	30630542	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattttgcatctcagagaatCtccttttgggaatcttgtct	8	17	7	9	0	4	1	1	0	4	1	6	3	4	2	1	1	1	1	1	1	2	5			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr10:30630542C>G	uc001iva.3	-	2	248	c.185G>C	c.(184-186)AGA>ACA	p.R62T	MTPAP_uc001ivb.3_Missense_Mutation_p.R192T|MTPAP_uc001ivc.2_Missense_Mutation_p.R62T	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor	62					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						CTCAGAGAATCTCCTTTTGGG	0.348													6	82					0	0	0	0	G	30630542	G	G	30630542	3	3	146	1	0	0	0	0	1	0	0	0	10009	913	32	2	1595	2	MTPAP	10	30630542	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	2401655	30630542	104904205	39	26876											
C10orf11	83938	broad.mit.edu	37	chr10	77818491	77818491	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaaagtaaccagacaagaaCgagaggaggcgttggtcaga	17	4	14	6	2	1	5	1	0	0	5	1	7	1	6	1	3	2	2	1	3	4	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr10:77818491C>T	uc001jxi.2	+	4	597	c.382C>T	c.(382-384)CGA>TGA	p.R128*		NM_032024	NP_114413	Q9H2I8	CJ011_HUMAN	chromosome 10 open reading frame 11	128	LRRCT.										0	Prostate(51;0.0095)|all_epithelial(25;0.0221)					CAGACAAGAACGAGAGGAGGC	0.478													13	106					0	0	0	0	T	77818491	T	T	77818491	4	4	146	1	0	0	0	0	0	1	0	0	1588	528	19	1	396	1	C10orf11	10	77818491	Nonsense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	47187949	77818491	57716256	40	26877											
MUC6	4588	broad.mit.edu	37	chr11	1018367	1018367	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatggtacctgttggcgcTgagtggttggaggcagatgt	7	11	18	5	1	0	2	0	1	0	1	0	4	0	4	1	6	1	5	1	6	2	3			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr11:1018367T>A	uc001lsw.2	-	31	4485	c.4434A>T	c.(4432-4434)TCA>TCT	p.S1478S		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1478	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTGTTGGCGCTGAGTGGTTGG	0.587													20	206					0	0	0	0	A	1018367	A	A	1018367	2	1	146	1	0	0	0	0	0	0	0	1	10033	1567	55	5		5	MUC6	11	1018367	Silent	SNP	T	TCGA-CR-7376-01A-11D-2129-08		1018367	133988149	41	26878											
MOB2	81532	broad.mit.edu	37	chr11	1501645	1501645	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgcacacggccatcgtctGacacgtctctcctgtgcaga	7	10	10	14	3	2	2	0	1	2	1	5	2	3	2	2	1	2	3	2	1	0	1			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr11:1501645G>A	uc010qwz.1	-	3	533	c.343C>T	c.(343-345)CAG>TAG	p.Q115*	MOB2_uc001lto.1_5'UTR|MOB2_uc001ltp.1_5'UTR|MOB2_uc001ltq.1_Nonsense_Mutation_p.Q78*|MOB2_uc010qwy.1_5'UTR	NM_053005	NP_443731	Q70IA6	MOB2_HUMAN	HCCA2 protein	84						nucleus|perinuclear region of cytoplasm	metal ion binding				0						GCCATCGTCTGACACGTCTCT	0.587													10	82					0	0	0	0	A	1501645	A	A	1501645	4	1	146	1	0	0	0	0	0	1	0	0	9734	1299	45	2	475	2	MOB2	11	1501645	Nonsense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	483278	1501645	133504871	42	26879											
CSRP3	8048	broad.mit.edu	37	chr11	19213969	19213969	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcttttcacaggctccacaTtttgcgcctccgccccagtt	5	13	7	16	2	2	0	1	0	1	0	4	0	4	0	5	1	1	2	5	1	0	5			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr11:19213969T>G	uc001mpk.2	-	2	144	c.27A>C	c.(25-27)AAA>AAC	p.K9N		NM_003476	NP_003467	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3	9					cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding				0						AGGCTCCACATTTTGCGCCTC	0.498													3	45					0	0	0	0	G	19213969	G	G	19213969	3	3	146	1	0	0	0	0	1	0	0	0	3986	1490	52	5	577	5	CSRP3	11	19213969	Missense_Mutation	SNP	T	TCGA-CR-7376-01A-11D-2129-08	17712324	19213969	115792547	43	26880											
C11orf59	55004	broad.mit.edu	37	chr11	71808908	71808908	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccagctcctcttttgcgTccacacggatctgagaaagt	10	10	8	13	2	2	1	0	1	2	1	4	3	4	2	3	1	3	1	3	1	2	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr11:71808908T>A	uc001ort.2	-	5	498	c.446A>T	c.(445-447)GAC>GTC	p.D149V	LRTOMT_uc010rqv.1_Intron|LRTOMT_uc010rqw.1_Intron|LRTOMT_uc001ors.3_Intron|C11orf59_uc009ytb.2_Silent_p.G73G|C11orf59_uc001oru.1_3'UTR	NM_017907	NP_060377	Q6IAA8	LTOR1_HUMAN	hypothetical protein LOC55004	149	Interaction with LAMTOR2 and LAMTOR3 (By similarity).				cell growth|cellular protein localization|cellular response to amino acid stimulus|cholesterol homeostasis|endosome localization|endosome organization|lysosome localization|lysosome organization|positive regulation of MAPKKK cascade|positive regulation of TOR signaling cascade|regulation of cholesterol efflux|regulation of cholesterol esterification|regulation of cholesterol import|regulation of receptor recycling	Golgi apparatus|lysosomal membrane|plasma membrane|Ragulator complex	protein binding				0						CTCTTTTGCGTCCACACGGAT	0.463													18	238					0	0	0	0	A	71808908	A	A	71808908	3	1	146	1	0	0	0	0	1	0	0	0	1658	1667	58	5	43	5	C11orf59	11	71808908	Missense_Mutation	SNP	T	TCGA-CR-7376-01A-11D-2129-08	52594939	71808908	63197608	44	26881											
TMEM25	84866	broad.mit.edu	37	chr11	118404820	118404820	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccgtccaaccttcagctcAatgacctcactccagattcc	9	10	4	18	1	3	2	3	1	0	1	7	2	7	2	6	0	2	1	6	0	2	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr11:118404820A>T	uc010rye.1	+	7	1087	c.913A>T	c.(913-915)AAT>TAT	p.N305Y	TMEM25_uc001ptk.3_Missense_Mutation_p.N305Y|TMEM25_uc001pth.2_Missense_Mutation_p.N261Y|TMEM25_uc009zad.2_Missense_Mutation_p.N261Y|TMEM25_uc001pti.2_Missense_Mutation_p.N157Y|TMEM25_uc010ryf.1_Missense_Mutation_p.N208Y|TMEM25_uc001ptl.2_Missense_Mutation_p.N305Y|TMEM25_uc001ptm.2_Missense_Mutation_p.N261Y|TMEM25_uc001ptn.2_Missense_Mutation_p.N261Y	NM_032780	NP_116169	Q86YD3	TMM25_HUMAN	transmembrane protein 25 isoform 1	305	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		CCTTCAGCTCAATGACCTCAC	0.517													7	46					0	0	0	0	T	118404820	T	T	118404820	3	4	146	1	0	0	0	0	1	0	0	0	16216	130	5	5	935	5	TMEM25	11	118404820	Missense_Mutation	SNP	A	TCGA-CR-7376-01A-11D-2129-08	46595912	118404820	16601696	45	26882											
DCP1B	196513	broad.mit.edu	37	chr12	2107117	2107117	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttaccttgtataaacaaataAggttccttccacatcagttt	13	15	4	9	0	1	0	1	0	0	0	3	0	3	0	3	1	2	3	3	1	6	8			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr12:2107117A>T	uc001qjx.1	-	2	255	c.175T>A	c.(175-177)TTA>ATA	p.L59I	DCP1B_uc010sdy.1_5'UTR|DCP1B_uc010sdz.1_Missense_Mutation_p.L59I	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	59					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			TAAACAAATAAGGTTCCTTCC	0.308													7	81					0	0	0	0	T	2107117	T	T	2107117	3	4	146	1	0	0	0	0	1	0	0	0	4316	69	3	5	1710	5	DCP1B	12	2107117	Missense_Mutation	SNP	A	TCGA-CR-7376-01A-11D-2129-08		2107117	131744778	46	26883											
A2M	2	broad.mit.edu	37	chr12	9251236	9251236	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctcagcatcaggcttcatGagcagcacgctttggtccac	9	9	10	13	1	3	1	3	1	0	0	4	1	4	1	1	2	4	6	1	2	0	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr12:9251236G>A	uc001qvk.1	-	15	1931	c.1818C>T	c.(1816-1818)CTC>CTT	p.L606L	A2M_uc009zgk.1_Silent_p.L456L	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	606					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CAGGCTTCATGAGCAGCACGC	0.617													3	17					0	0	0	0	A	9251236	A	A	9251236	2	1	146	1	0	0	0	0	0	0	0	1	4	1277	45	2		2	A2M	12	9251236	Silent	SNP	G	TCGA-CR-7376-01A-11D-2129-08	7144119	9251236	124600659	47	26884											
CAPRIN2	65981	broad.mit.edu	37	chr12	30869532	30869532	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttgctgtggtaaaactttGattgtagccaggtgaataag	12	13	11	5	0	0	2	0	2	0	0	0	2	0	2	1	2	3	3	1	2	5	6			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr12:30869532G>C	uc001rji.1	-	14	3125	c.2374C>G	c.(2374-2376)CAA>GAA	p.Q792E	CAPRIN2_uc001rjf.1_Missense_Mutation_p.Q589E|CAPRIN2_uc001rjg.1_Missense_Mutation_p.Q459E|CAPRIN2_uc001rjh.1_Missense_Mutation_p.Q743E|CAPRIN2_uc001rjj.1_Missense_Mutation_p.Q459E|CAPRIN2_uc001rjk.3_Missense_Mutation_p.Q792E|CAPRIN2_uc001rjl.3_Missense_Mutation_p.Q757E|CAPRIN2_uc001rjm.1_Missense_Mutation_p.Q424E	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	792					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GTAAAACTTTGATTGTAGCCA	0.408													14	190					0	0	0	0	C	30869532	C	C	30869532	3	2	146	1	0	0	0	0	1	0	0	0	2648	1299	45	2	1029	2	CAPRIN2	12	30869532	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	21618296	30869532	102982363	48	26885											
ANO6	196527	broad.mit.edu	37	chr12	45782051	45782051	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgaccagaatacgaagcaCgatgtactcacgtagtgata	14	7	9	11	4	1	2	1	1	0	1	1	5	1	2	2	0	3	3	2	0	6	4			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr12:45782051C>G	uc001roo.2	+	11	1608	c.1273C>G	c.(1273-1275)CGA>GGA	p.R425G	ANO6_uc010sld.1_Missense_Mutation_p.R425G|ANO6_uc010sle.1_Missense_Mutation_p.R425G|ANO6_uc010slf.1_Missense_Mutation_p.R446G|ANO6_uc010slg.1_Missense_Mutation_p.R407G	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	425	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						ATACGAAGCACGATGTACTCA	0.393													10	120					0	0	0	0	G	45782051	G	G	45782051	3	3	146	1	0	0	0	0	1	0	0	0	701	528	19	3	1335	3	ANO6	12	45782051	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	14912519	45782051	88069844	49	26886											
CRY1	1407	broad.mit.edu	37	chr12	107393445	107393445	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctgtgtcatgatggcatCaatccatggaaagcctgtcc	11	10	10	10	0	2	1	2	1	0	0	4	2	4	2	3	2	2	2	3	2	3	0			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr12:107393445C>G	uc001tmi.3	-	7	1880	c.1021G>C	c.(1021-1023)GAT>CAT	p.D341H		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	341	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						ATGATGGCATCAATCCATGGA	0.493													4	61					0	0	0	0	G	107393445	G	G	107393445	3	3	146	1	0	0	0	0	1	0	0	0	3918	826	29	2	763	2	CRY1	12	107393445	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	61611394	107393445	26458450	50	26887											
RNF34	80196	broad.mit.edu	37	chr12	121867998	121867998	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaattgcgttgtggtctgttGtcccacgttccaaatggaaa	9	13	11	8	2	1	0	0	0	1	0	3	2	3	1	2	2	1	3	2	2	3	4			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr12:121867998G>T	uc001uam.1	+	7	1339	c.1225G>T	c.(1225-1227)GTC>TTC	p.V409F	KDM2B_uc001uaq.2_Intron|KDM2B_uc010szy.1_3'UTR|KDM2B_uc001uar.2_Intron|KDM2B_uc001uas.2_Intron|KDM2B_uc001uat.2_3'UTR|KDM2B_uc001uau.2_3'UTR|KDM2B_uc001uao.2_Intron|KDM2B_uc010szx.1_3'UTR|KDM2B_uc001uap.2_Intron	NM_025126	NP_079402	Q969K3	RNF34_HUMAN	ring finger protein 34 isoform 2	Error:Variant_position_missing_in_Q969K3_after_alignment					apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		GTGGTCTGTTGTCCCACGTTC	0.473													8	79					0.000157383	0.000171219	1	0	T	121867998	T	T	121867998	3	4	146	1	0	0	0	0	1	0	0	0	13554	1392	48	4		4	RNF34	12	121867998	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	14474553	121867998	11983897	51	26888											
NBEA	26960	broad.mit.edu	37	chr13	36229804	36229804	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attggtggggactgctacatCgtgtccggatctcgagatgc	7	11	14	9	3	1	1	0	0	1	1	4	4	2	3	1	4	3	1	1	4	1	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr13:36229804C>T	uc001uvb.2	+	54	8423	c.8217C>T	c.(8215-8217)ATC>ATT	p.I2739I	NBEA_uc010abi.2_Silent_p.I1395I|NBEA_uc010tef.1_Silent_p.I532I|NBEA_uc001uvd.2_Silent_p.I317I	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2739	WD 2.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ACTGCTACATCGTGTCCGGAT	0.512													5	126					0	0	0	0	T	36229804	T	T	36229804	2	4	146	1	0	0	0	0	0	0	0	1	10240	874	31	1		1	NBEA	13	36229804	Silent	SNP	C	TCGA-CR-7376-01A-11D-2129-08		36229804	78940074	52	26889											
HEATR5A	25938	broad.mit.edu	37	chr14	31774252	31774252	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttagggtttaattctgggaGctgtctaactagaatgcata	11	15	10	5	0	2	1	0	0	2	1	2	2	2	2	0	2	3	3	0	2	6	8			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr14:31774252G>A	uc001wrf.3	-	26	4296	c.4219C>T	c.(4219-4221)CTC>TTC	p.L1407F	HEATR5A_uc010ami.2_Missense_Mutation_p.L1305F	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1694							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		AATTCTGGGAGCTGTCTAACT	0.448													16	108					0	0	0	0	A	31774252	A	A	31774252	3	1	146	1	0	0	0	0	1	0	0	0	7070	971	34	4	1062	4	HEATR5A	14	31774252	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08		31774252	75575288	53	26890											
CCDC88C	440193	broad.mit.edu	37	chr14	91780018	91780018	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgctggtgaagcgcatggtCtccaccagcctgcgcagctc	6	8	13	14	2	1	1	0	1	1	0	3	1	1	1	3	2	5	4	3	2	1	0			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr14:91780018C>G	uc010aty.2	-	15	2241	c.2142G>C	c.(2140-2142)GAG>GAC	p.E714D		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	714	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				AGCGCATGGTCTCCACCAGCC	0.602													6	75					0	0	0	0	G	91780018	G	G	91780018	3	3	146	1	0	0	0	0	1	0	0	0	2878	912	32	2	4008	2	CCDC88C	14	91780018	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	60005766	91780018	15569522	54	26891											
VRK1	7443	broad.mit.edu	37	chr14	97321591	97321591	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagattatggccttgcttatCggtactgcccagaaggagtt	9	13	11	8	1	0	2	0	0	0	2	1	3	0	3	2	3	3	3	2	3	5	6	rs144600646	by1000genomes	TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr14:97321591C>T	uc001yft.2	+	8	713	c.607C>T	c.(607-609)CGG>TGG	p.R203W		NM_003384	NP_003375	Q99986	VRK1_HUMAN	vaccinia related kinase 1	203	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|stomach(1)	2		Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.234)		CCTTGCTTATCGGTACTGCCC	0.408													7	103					0	0	0	0	T	97321591	T	T	97321591	3	4	146	1	0	0	0	0	1	0	0	0	17287	875	31	1	633	1	VRK1	14	97321591	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	5541573	97321591	10027949	55	26892											
RNF40	9810	broad.mit.edu	37	chr16	30777510	30777510	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgctgaatgcagagttagaGgaaaaccaggaactggccaa	16	6	12	7	0	0	3	0	1	0	2	0	5	0	5	2	3	4	3	2	3	6	1			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr16:30777510G>C	uc002dzq.2	+	9	1143	c.1020G>C	c.(1018-1020)GAG>GAC	p.E340D	RNF40_uc010caa.2_Missense_Mutation_p.E340D|RNF40_uc010cab.2_Intron|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Missense_Mutation_p.E340D|RNF40_uc010vfb.1_Intron|RNF40_uc010vfc.1_5'Flank	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	340	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			CAGAGTTAGAGGAAAACCAGG	0.592													5	92					0	0	0	0	C	30777510	C	C	30777510	3	2	146	1	0	0	0	0	1	0	0	0	13558	991	35	4	1050	4	RNF40	16	30777510	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08		30777510	59577243	56	26893											
HPR	3250	broad.mit.edu	37	chr16	72108189	72108189	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctctctttgcagatgaccGcttcccgaagccccctgaga	7	10	8	16	2	2	3	0	2	2	2	4	5	3	3	4	0	2	2	4	0	1	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr16:72108189G>A	uc002fby.2	+	3	128	c.98G>A	c.(97-99)CGC>CAC	p.R33H	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	33					proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				GCAGATGACCGCTTCCCGAAG	0.483													12	75					0	0	0	0	A	72108189	A	A	72108189	3	1	146	1	0	0	0	0	1	0	0	0	7376	1087	38	1	108	1	HPR	16	72108189	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	41330679	72108189	18246564	57	26894											
DPEP1	1800	broad.mit.edu	37	chr16	89696859	89696859	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggccccttgtggccgtctGcactgcagacttctttcggg	3	12	13	13	2	2	1	0	0	2	1	3	1	2	1	3	3	2	2	3	3	0	3			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr16:89696859G>A	uc010cin.2	+	2	244	c.41G>A	c.(40-42)TGC>TAC	p.C14Y	DPEP1_uc002fnr.3_Missense_Mutation_p.C14Y|DPEP1_uc002fns.3_Missense_Mutation_p.C14Y	NM_001128141	NP_001121613	P16444	DPEP1_HUMAN	dipeptidase 1 precursor	14					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(1)	1		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	GTGGCCGTCTGCACTGCAGAC	0.632													10	72					0	0	0	0	A	89696859	A	A	89696859	3	1	146	1	0	0	0	0	1	0	0	0	4735	1319	46	4	43	4	DPEP1	16	89696859	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	17588670	89696859	657894	58	26895											
TP53	7157	broad.mit.edu	37	chr17	7577098	7577098	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcctctgtgcgccggtcTctcccaggacaggcacaaac	7	9	9	16	2	3	0	0	0	3	0	6	1	5	1	3	3	2	1	3	3	1	1			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr17:7577098T>G	uc002gim.2	-	8	1034	c.840A>C	c.(838-840)AGA>AGC	p.R280S	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148S|TP53_uc010cng.1_Missense_Mutation_p.R148S|TP53_uc002gii.1_Missense_Mutation_p.R148S|TP53_uc010cnh.1_Missense_Mutation_p.R280S|TP53_uc010cni.1_Missense_Mutation_p.R280S|TP53_uc002gij.2_Missense_Mutation_p.R280S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCGCCGGTCTCTCCCAGGAC	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	36					0	0	0	0	G	7577098	G	G	7577098	3	3	146	1	0	0	0	0	1	0	0	0	16448	1548	54	5	446	5	TP53	17	7577098	Missense_Mutation	SNP	T	TCGA-CR-7376-01A-11D-2129-08		7577098	73618112	59	26896											
TP53	7157	broad.mit.edu	37	chr17	7579698	7579699	+	Splice_Site	INS	-	CC	CC																															cagcccaacccttgtccttaINSccagaacgttgttttcagga																										TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr17:7579698_7579699insCC	uc002gim.2	-	3	290	c.96_splice	c.e3+1	p.L32_splice	TP53_uc002gig.1_Splice_Site_p.L32_splice|TP53_uc002gih.2_Splice_Site_p.L32_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Splice_Site_p.L32_splice|TP53_uc010cni.1_Splice_Site_p.L32_splice|TP53_uc002gij.2_Splice_Site_p.L32_splice|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Splice_Site_p.L32_splice|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Splice_Site|TP53_uc010cnk.1_Splice_Site_p.L47_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(2)|p.S33fs*10(1)|p.P13fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTGTCCTTACCAGAACGTTG	0.381		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								CC	7579699	CC	CC	7579698	8	5	146	1	0	1	1	0	0	0	1	0	16448	405	14	0	1208	0	TP53	17	7579698	Splice_Site	INS	-	TCGA-CR-7376-01A-11D-2129-08	2600	7579698	73615512	60	26897											
MYH2	4620	broad.mit.edu	37	chr17	10427914	10427914	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagcaggttggctctgcGctccaccatggccagctgtt	5	10	12	14	1	1	0	0	0	1	0	2	0	2	0	3	3	4	7	3	3	0	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr17:10427914G>A	uc010coi.2	-	35	5172	c.5044C>T	c.(5044-5046)CGC>TGC	p.R1682C	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1682C|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1682	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TTGGCTCTGCGCTCCACCATG	0.567													6	58					0	0	0	0	A	10427914	A	A	10427914	3	1	146	1	0	0	0	0	1	0	0	0	10088	1087	38	1	805	1	MYH2	17	10427914	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	2848216	10427914	70767296	61	26898											
COL1A1	1277	broad.mit.edu	37	chr17	48273002	48273002	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggggaccttcagagcctcGgggcccttggggaccagctt	5	8	15	13	1	1	1	1	0	0	1	2	3	1	3	4	6	2	1	4	6	0	3	rs72645366		TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr17:48273002G>A	uc002iqm.2	-	17	1207	c.1081C>T	c.(1081-1083)CGA>TGA	p.R361*		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	361	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	TCAGAGCCTCGGGGCCCTTGG	0.637			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta				OREG0024559	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	39					0	0	0	0	A	48273002	A	A	48273002	4	1	146	1	0	0	0	0	0	1	0	0	3692	1124	39	1	3453	1	COL1A1	17	48273002	Nonsense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	37845088	48273002	32922208	62	26899											
ASXL3	80816	broad.mit.edu	37	chr18	31326305	31326305	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttggtagcacgagtttcAaaagggcagcatctgcaatt	12	11	10	8	1	2	0	1	0	1	0	2	1	2	0	0	2	3	6	0	2	4	4			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr18:31326305A>C	uc010dmg.1	+	12	6548	c.6493A>C	c.(6493-6495)AAA>CAA	p.K2165Q	ASXL3_uc002kxq.2_Missense_Mutation_p.K1872Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CACGAGTTTCAAAAGGGCAGC	0.468													10	140					0	0	0	0	C	31326305	C	C	31326305	3	2	146	1	0	0	0	0	1	0	0	0	1070	131	5	5	6539	5	ASXL3	18	31326305	Missense_Mutation	SNP	A	TCGA-CR-7376-01A-11D-2129-08		31326305	46750943	63	26900											
KIAA1328	57536	broad.mit.edu	37	chr18	34539358	34539358	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaggagaagctcaccatgtCtctctcagaacttggtgctg	10	10	10	11	0	3	2	2	0	2	2	5	3	3	2	1	2	3	2	1	2	2	1			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr18:34539358C>G	uc002kzz.2	+	6	558	c.536C>G	c.(535-537)TCT>TGT	p.S179C	KIAA1328_uc002lab.2_Intron|KIAA1328_uc002lac.1_Missense_Mutation_p.S2C|KIAA1328_uc010dnc.1_RNA	NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	179										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		CTCACCATGTCTCTCTCAGAA	0.408													2	16					0	0	0	0	G	34539358	G	G	34539358	3	3	146	1	0	0	0	0	1	0	0	0	8264	913	32	2	558	2	KIAA1328	18	34539358	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	3213053	34539358	43537890	64	26901											
ZNF236	7776	broad.mit.edu	37	chr18	74580734	74580734	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaggagctggctggaaccCggcagcatgcctgcaaggcc	8	4	15	14	1	0	0	0	0	0	0	0	2	0	2	4	5	5	5	4	5	2	0			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr18:74580734C>T	uc002lmi.2	+	4	649	c.451C>T	c.(451-453)CGG>TGG	p.R151W	ZNF236_uc002lmj.2_RNA|ZNF236_uc002lmk.1_Missense_Mutation_p.R151W	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	151					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GGCTGGAACCCGGCAGCATGC	0.522													7	133					0	0	0	0	T	74580734	T	T	74580734	3	4	146	1	0	0	0	0	1	0	0	0	17856	643	23	1	465	1	ZNF236	18	74580734	Missense_Mutation	SNP	C	TCGA-CR-7376-01A-11D-2129-08	40041376	74580734	3496514	65	26902											
HCN2	610	broad.mit.edu	37	chr19	613894	613894	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgccgcacggcgagcgtgcGggctgacacctactgccgcc	5	4	14	18	7	0	1	0	1	0	0	0	2	0	1	5	2	4	2	5	2	1	1			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr19:613894G>A	uc002lpe.2	+	7	1921	c.1868G>A	c.(1867-1869)CGG>CAG	p.R623Q		NM_001194	NP_001185	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic	623	cAMP.|Cytoplasmic (Potential).				cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGAGCGTGCGGGCTGACACC	0.716													4	34					0	0	0	0	A	613894	A	A	613894	3	1	146	1	0	0	0	0	1	0	0	0	7036	1116	39	1	1894	1	HCN2	19	613894	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08		613894	58515089	66	26903											
ZNF486	90649	broad.mit.edu	37	chr19	20295277	20295277	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgttagagaactacagacAcctggtcttccttggtgagg	10	11	12	8	0	1	3	0	1	1	2	2	5	2	3	2	3	2	1	2	3	3	4			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr19:20295277A>C	uc002nou.2	+	2	200	c.143A>C	c.(142-144)CAC>CCC	p.H48P		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	48	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AACTACAGACACCTGGTCTTC	0.363													11	161					0	0	0	0	C	20295277	C	C	20295277	3	2	146	1	0	0	0	0	1	0	0	0	18006	159	6	5	149	5	ZNF486	19	20295277	Missense_Mutation	SNP	A	TCGA-CR-7376-01A-11D-2129-08	19681383	20295277	38833706	67	26904											
KLK12	43849	broad.mit.edu	37	chr19	51532606	51532606	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagtccacatacttgcaaatAtaggtgtagactccagggat	13	10	9	9	0	0	1	0	0	0	1	2	2	2	2	2	2	2	2	2	2	5	5			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr19:51532606A>G	uc002pvg.1	-	5	819	c.699T>C	c.(697-699)TAT>TAC	p.Y233Y	KLK11_uc002pvd.1_5'Flank|KLK11_uc002pve.1_5'Flank|KLK11_uc002pvf.1_5'Flank|KLK11_uc002pvc.3_5'Flank|KLK11_uc010eom.2_5'Flank|KLK12_uc010ycp.1_RNA|KLK12_uc010ycq.1_Silent_p.Y123Y|KLK12_uc010ycr.1_Silent_p.Y123Y|KLK12_uc010ycs.1_Silent_p.Y123Y|KLK12_uc002pvh.1_Silent_p.Y233Y|KLK12_uc002pvi.1_Silent_p.Y233Y|KLK12_uc002pvj.1_3'UTR	NM_145894	NP_665901	Q9UKR0	KLK12_HUMAN	kallikrein 12 isoform 2	233	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			ovary(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		ACTTGCAAATATAGGTGTAGA	0.587													13	113					0	0	0	0	G	51532606	G	G	51532606	2	3	146	1	0	0	0	0	0	0	0	1	8439	456	16	5		5	KLK12	19	51532606	Silent	SNP	A	TCGA-CR-7376-01A-11D-2129-08	31237329	51532606	7596377	68	26905											
ZNF335	63925	broad.mit.edu	37	chr20	44592204	44592204	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgggagttgacgtggaagcGcaggtcctcgtgggacagaa	10	7	17	7	3	0	2	0	1	0	1	2	5	1	5	1	4	1	2	1	4	2	1	rs141481390		TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chr20:44592204G>A	uc002xqw.2	-	9	1564	c.1441C>T	c.(1441-1443)CGC>TGC	p.R481C	ZNF335_uc010zxk.1_Missense_Mutation_p.R326C	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	481	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				ACGTGGAAGCGCAGGTCCTCG	0.587													8	154					0	0	0	0	A	44592204	A	A	44592204	3	1	146	1	0	0	0	0	1	0	0	0	17919	1087	38	1	2667	1	ZNF335	20	44592204	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08		44592204	18433316	69	26906											
GLRA2	2742	broad.mit.edu	37	chrX	14550468	14550468	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaaggacatcaggatatgAtgcaagaatcaggccaaatt	16	7	12	6	0	2	2	2	1	0	1	2	5	2	5	1	4	1	1	1	4	5	2			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chrX:14550468A>G	uc010nep.2	+	3	508	c.176A>G	c.(175-177)GAT>GGT	p.D59G	GLRA2_uc010neq.2_Missense_Mutation_p.D59G|GLRA2_uc004cwe.3_Missense_Mutation_p.D59G|GLRA2_uc011mio.1_5'UTR|GLRA2_uc011mip.1_Missense_Mutation_p.D37G	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	59	Extracellular (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	TCAGGATATGATGCAAGAATC	0.378													10	43					0	0	0	0	G	14550468	G	G	14550468	3	3	146	1	0	0	0	0	1	0	0	0	6492	333	12	5	182	5	GLRA2	23	14550468	Missense_Mutation	SNP	A	TCGA-CR-7376-01A-11D-2129-08		14550468	140720092	70	26907											
RBBP7	5931	broad.mit.edu	37	chrX	16870184	16870184	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttaccttaaatcccacacaTtcaggcggcggtcagtacca	11	9	8	13	2	2	0	2	0	0	0	3	0	3	0	3	3	2	2	3	3	4	4			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chrX:16870184T>G	uc004cxt.2	-	9	1383	c.1025A>C	c.(1024-1026)AAT>ACT	p.N342T	RBBP7_uc004cxs.1_Missense_Mutation_p.N386T|RBBP7_uc004cxu.2_Missense_Mutation_p.N333T	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	342	WD 6.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					ATCCCACACATTCAGGCGGCG	0.368													17	111					0	0	0	0	G	16870184	G	G	16870184	3	3	146	1	0	0	0	0	1	0	0	0	13169	1493	52	5	268	5	RBBP7	23	16870184	Missense_Mutation	SNP	T	TCGA-CR-7376-01A-11D-2129-08	2319716	16870184	138400376	71	26908											
ELF4	2000	broad.mit.edu	37	chrX	129201444	129201444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgtctgcagggtcagggccGagcccgaccccacgggggcc	5	4	16	16	4	2	0	1	0	1	0	3	2	2	0	5	4	2	1	5	4	0	0			TCGA-CR-7376-01A-11D-2129-08	TCGA-CR-7376-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6b11f68-79da-4542-818d-f404116c0bf8	47cf1857-e93d-470f-abe2-bebe102fb2c1	g.chrX:129201444G>A	uc004evd.3	-	9	1629	c.1244C>T	c.(1243-1245)TCG>TTG	p.S415L	ELF4_uc004eve.3_Missense_Mutation_p.S415L	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	415					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGTCAGGGCCGAGCCCGACCC	0.587			T	ERG	AML								12	46					0	0	0	0	A	129201444	A	A	129201444	3	1	146	1	0	0	0	0	1	0	0	0	5080	1059	37	1	751	1	ELF4	23	129201444	Missense_Mutation	SNP	G	TCGA-CR-7376-01A-11D-2129-08	112331260	129201444	26069116	72	26909											
SPATA21	374955	broad.mit.edu	37	chr1	16727317	16727317	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtagggaagcttctgcaaccGcagccggcctacggccgctt	7	7	13	14	4	1	0	0	0	1	0	1	1	1	1	4	3	5	5	4	3	4	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:16727317G>A	uc001ayn.2	-	11	1555	c.1072C>T	c.(1072-1074)CGG>TGG	p.R358W	SPATA21_uc001ayl.1_RNA|SPATA21_uc010occ.1_Missense_Mutation_p.R335W	NM_198546	NP_940948	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	358							calcium ion binding			ovary(2)|breast(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		TTCTGCAACCGCAGCCGGCCT	0.582													6	264					0	0	0	0	A	16727317	A	A	16727317	3	1	147	1	0	0	0	0	1	0	0	0	15073	1086	38	1	349	1	SPATA21	1	16727317	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08		16727317	232523304	1	26910											
SASS6	163786	broad.mit.edu	37	chr1	100572486	100572486	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacttttcattattttttaGaagttgtttgctttcttcaa	9	22	4	6	0	3	1	2	0	1	1	3	1	3	1	0	0	1	3	0	0	4	10			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:100572486G>A	uc001dsu.2	-	12	1531	c.1390C>T	c.(1390-1392)CTA>TTA	p.L464L	SASS6_uc009wdz.2_Silent_p.L297L	NM_194292	NP_919268	Q6UVJ0	SAS6_HUMAN	spindle assembly abnormal protein 6	464	Potential.				centriole replication	centriole				upper_aerodigestive_tract(1)|ovary(1)	2		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		TTATTTTTTAGAAGTTGTTTG	0.214													3	20					0	0	0	0	A	100572486	A	A	100572486	2	1	147	1	0	0	0	0	0	0	0	1	13915	933	33	2		2	SASS6	1	100572486	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08	83845169	100572486	148678135	2	26911											
STXBP3	6814	broad.mit.edu	37	chr1	109340774	109340774	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaattgtattagtctcaacAaggcaaaccgttaagaaagg	16	10	8	7	1	1	1	1	0	1	1	2	1	1	1	1	2	2	3	1	2	8	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:109340774A>C	uc001dvy.2	+	16	1439	c.1364A>C	c.(1363-1365)CAA>CCA	p.Q455P	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	455					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TAGTCTCAACAAGGCAAACCG	0.313													29	113					0	0	0	0	C	109340774	C	C	109340774	3	2	147	1	0	0	0	0	1	0	0	0	15420	130	5	5	1426	5	STXBP3	1	109340774	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	8768288	109340774	139909847	3	26912											
SYT6	148281	broad.mit.edu	37	chr1	114680442	114680442	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtcaaaagccttcaggataCgcacaatcagggtctcggtc	11	8	11	11	2	4	0	3	0	1	0	6	1	4	1	1	4	2	1	1	4	4	2	rs139165674	byFrequency	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:114680442C>T	uc001eev.2	-	3	741	c.491G>A	c.(490-492)CGT>CAT	p.R164H		NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	249	Cytoplasmic (Potential).|C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCAGGATACGCACAATCAG	0.542													32	89					0	0	0	0	T	114680442	T	T	114680442	3	4	147	1	0	0	0	0	1	0	0	0	15544	536	19	1	806	1	SYT6	1	114680442	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	5339668	114680442	134570179	4	26913											
PTGFRN	5738	broad.mit.edu	37	chr1	117492010	117492010	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattccctggtgcacagctcGcctcatgttgctttgagtca	6	13	10	12	1	2	1	2	1	0	0	4	2	3	1	2	1	3	4	2	1	0	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:117492010G>A	uc001egv.1	+	4	1166	c.1029G>A	c.(1027-1029)TCG>TCA	p.S343S		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	343	Ig-like C2-type 3.|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		TGCACAGCTCGCCTCATGTTG	0.572													11	89					0	0	0	0	A	117492010	A	A	117492010	2	1	147	1	0	0	0	0	0	0	0	1	12813	1074	38	1		1	PTGFRN	1	117492010	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08	2811568	117492010	131758611	5	26914											
HIST2H2AC	8338	broad.mit.edu	37	chr1	149858559	149858559	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaacaaggaggcaaggcccGcgccaaggccaagtcgcgct	12	2	13	14	4	0	0	0	0	0	0	1	1	0	1	3	4	1	2	3	4	5	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:149858559G>C	uc001etd.2	+	1	35	c.35G>C	c.(34-36)CGC>CCC	p.R12P	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	12					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGCAAGGCCCGCGCCAAGGCC	0.582													12	128					0	0	0	0	C	149858559	C	C	149858559	3	2	147	1	0	0	0	0	1	0	0	0	7217	1087	38	3	37	3	HIST2H2AC	1	149858559	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	32366549	149858559	99392062	6	26915											
THEM5	284486	broad.mit.edu	37	chr1	151824773	151824773	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatgggagcttgagtccccGgatgtggtctctgttggact	6	12	15	8	1	1	2	0	1	1	1	3	5	2	5	2	4	1	2	2	4	0	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:151824773G>A	uc009wnd.2	-	2	418	c.286C>T	c.(286-288)CGG>TGG	p.R96W		NM_182578	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	96							hydrolase activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TTGAGTCCCCGGATGTGGTCT	0.542													19	139					0	0	0	0	A	151824773	A	A	151824773	3	1	147	1	0	0	0	0	1	0	0	0	15925	1115	39	1	477	1	THEM5	1	151824773	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	1966214	151824773	97425848	7	26916											
NTRK1	4914	broad.mit.edu	37	chr1	156843527	156843527	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtctctgcgctggctcttcaAtggctccgtgctcaatgaga	6	12	11	12	2	4	1	2	1	2	1	6	2	5	1	1	2	2	4	1	2	2	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:156843527A>G	uc001fqh.1	+	8	1009	c.953A>G	c.(952-954)AAT>AGT	p.N318S	NTRK1_uc001fqf.1_Missense_Mutation_p.N288S|NTRK1_uc009wsi.1_Missense_Mutation_p.N23S|NTRK1_uc001fqi.1_Missense_Mutation_p.N318S|NTRK1_uc009wsk.1_Missense_Mutation_p.N318S	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	318	Ig-like C2-type 2.|Extracellular (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGGCTCTTCAATGGCTCCGTG	0.637			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			5	27					0	0	0	0	G	156843527	G	G	156843527	3	3	147	1	0	0	0	0	1	0	0	0	10760	101	4	5	1113	5	NTRK1	1	156843527	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	5018754	156843527	92407094	8	26917											
RNASEL	6041	broad.mit.edu	37	chr1	182554927	182554927	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgccccccagtgtgagctctGaggcttccagtcttcagcag	6	10	11	14	0	3	2	1	2	2	0	4	2	4	2	4	1	3	3	4	1	0	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:182554927G>A	uc001gpj.1	-	1	1182	c.1015C>T	c.(1015-1017)CAG>TAG	p.Q339*	RNASEL_uc009wxz.1_Nonsense_Mutation_p.Q339*|RNASEL_uc001gpk.2_Nonsense_Mutation_p.Q339*|RNASEL_uc009wya.1_Nonsense_Mutation_p.Q339*	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	339					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						TGTGAGCTCTGAGGCTTCCAG	0.463									Hereditary_Prostate_Cancer				11	84					0	0	0	0	A	182554927	A	A	182554927	4	1	147	1	0	0	0	0	0	1	0	0	13481	1299	45	2	1234	2	RNASEL	1	182554927	Nonsense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	25711400	182554927	66695694	9	26918											
DHX9	1660	broad.mit.edu	37	chr1	182812531	182812531	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgttaactatttggttcgaAtaaatgaaataaagagtgaa	17	14	8	2	1	0	3	0	2	0	1	1	4	0	3	0	1	1	2	0	1	9	7			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:182812531A>G	uc001gpr.2	+	3	377	c.214A>G	c.(214-216)ATA>GTA	p.I72V	DHX9_uc001gps.2_5'UTR	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	72	Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TTTGGTTCGAATAAATGAAAT	0.378													7	74					0	0	0	0	G	182812531	G	G	182812531	3	3	147	1	0	0	0	0	1	0	0	0	4538	101	4	5	220	5	DHX9	1	182812531	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	257604	182812531	66438090	10	26919											
HMCN1	83872	broad.mit.edu	37	chr1	186136045	186136045	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgttgtggaagtggctttcGaagaacctctgatgggctga	8	11	14	8	2	1	3	0	2	1	1	2	5	1	4	2	3	1	3	2	3	3	2	rs148826584	by1000genomes	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:186136045G>A	uc001grq.1	+	100	15774	c.15545G>A	c.(15544-15546)CGA>CAA	p.R5182Q	HMCN1_uc001grs.1_Missense_Mutation_p.R751Q	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5182	EGF-like 2; calcium-binding (Potential).				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGTGGCTTTCGAAGAACCTCT	0.458													10	68					0	0	0	0	A	186136045	A	A	186136045	3	1	147	1	0	0	0	0	1	0	0	0	7259	1058	37	1	15943	1	HMCN1	1	186136045	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	3323514	186136045	63114576	11	26920											
BTG2	7832	broad.mit.edu	37	chr1	203276431	203276431	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaggtgtcctaccgcattggGgaggacggctccatctgcgt	6	9	15	11	3	1	0	0	0	1	0	3	3	3	2	3	5	2	2	3	5	1	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:203276431G>A	uc001gzq.2	+	2	413	c.342G>A	c.(340-342)GGG>GGA	p.G114G	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	114					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			ACCGCATTGGGGAGGACGGCT	0.667													15	81					0	0	0	0	A	203276431	A	A	203276431	2	1	147	1	0	0	0	0	0	0	0	1	1559	1219	43	4		4	BTG2	1	203276431	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08	17140386	203276431	45974190	12	26921											
CD34	947	broad.mit.edu	37	chr1	208061164	208061164	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccggtcccgttttcctgAgcccctcggttcacactggc	3	11	11	16	3	1	1	1	1	0	0	4	1	3	1	5	4	1	2	5	4	0	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:208061164A>T	uc001hgw.1	-	8	1335	c.1077T>A	c.(1075-1077)GCT>GCA	p.A359A	CD34_uc001hgv.1_Silent_p.A201A|CD34_uc001hgx.1_3'UTR|CD34_uc010psj.1_Silent_p.A224A	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	359	Cytoplasmic (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						CGTTTTCCTGAGCCCCTCGGT	0.592													5	53					0	0	0	0	T	208061164	T	T	208061164	2	4	147	1	0	0	0	0	0	0	0	1	3021	291	11	5		5	CD34	1	208061164	Silent	SNP	A	TCGA-CR-7377-01A-11D-2012-08	4784733	208061164	41189457	13	26922											
TTC13	79573	broad.mit.edu	37	chr1	231060684	231060684	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggtccatgtacgctgcaCggcttgcatgacctccaatg	7	11	11	12	2	0	1	0	1	0	0	2	1	2	1	3	2	3	6	3	2	2	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:231060684C>T	uc001huf.3	-	14	1655	c.1624G>A	c.(1624-1626)GTG>ATG	p.V542M	TTC13_uc009xfi.2_Missense_Mutation_p.V489M|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.V489M|TTC13_uc009xfk.1_Missense_Mutation_p.V432M	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	542							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		GTACGCTGCACGGCTTGCATG	0.463													24	101					0	0	0	0	T	231060684	T	T	231060684	3	4	147	1	0	0	0	0	1	0	0	0	16748	536	19	1	998	1	TTC13	1	231060684	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	22999520	231060684	18189937	14	26923											
OR2T2	401992	broad.mit.edu	37	chr1	248616314	248616314	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctctccatcatggatacCatctacatctgtatcactgt	10	13	5	13	0	5	0	2	0	3	0	6	1	5	1	2	1	3	2	2	1	3	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:248616314C>A	uc001iek.1	+	1	216	c.216C>A	c.(214-216)ACC>ACA	p.T72T		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCATGGATACCATCTACATCT	0.512													16	189					3.51602e-12	4.38982e-12	1	0	A	248616314	A	A	248616314	2	1	147	1	0	0	0	0	0	0	0	1	11074	581	21	4		4	OR2T2	1	248616314	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	17555630	248616314	634307	15	26924											
OR2T2	401992	broad.mit.edu	37	chr1	248616457	248616457	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcctgctgggtctcatggCctatgaccgctatgtggctg	4	13	12	12	1	1	1	1	1	1	0	3	1	2	1	3	3	1	3	3	3	2	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr1:248616457C>A	uc001iek.1	+	1	359	c.359C>A	c.(358-360)GCC>GAC	p.A120D		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGTCTCATGGCCTATGACCGC	0.547													12	130					5.01169e-05	6.04267e-05	1	0	A	248616457	A	A	248616457	3	1	147	1	0	0	0	0	1	0	0	0	11074	739	26	4	361	4	OR2T2	1	248616457	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	143	248616457	634164	16	26925											
DTNB	1838	broad.mit.edu	37	chr2	25754408	25754408	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggatgcgggggttctctcGtgggtacacaccccaaagat	9	8	13	11	2	1	1	0	0	1	1	3	2	1	2	2	4	2	2	2	4	2	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:25754408G>C	uc002rgh.2	-	9	1185	c.935C>G	c.(934-936)ACG>AGG	p.T312R	DTNB_uc010yko.1_Missense_Mutation_p.T255R|DTNB_uc010ykp.1_Missense_Mutation_p.T108R|DTNB_uc002rgo.2_Missense_Mutation_p.T133R|DTNB_uc002rgi.2_Missense_Mutation_p.T312R|DTNB_uc002rgj.2_Missense_Mutation_p.T312R|DTNB_uc002rgk.2_Missense_Mutation_p.T312R|DTNB_uc002rgl.2_Missense_Mutation_p.T312R|DTNB_uc002rgq.2_Missense_Mutation_p.T312R|DTNB_uc002rgm.2_Missense_Mutation_p.T312R|DTNB_uc002rgn.2_Missense_Mutation_p.T108R|DTNB_uc002rgr.1_Missense_Mutation_p.T301R|DTNB_uc010ykq.1_Missense_Mutation_p.T165R	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	312						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGTTCTCTCGTGGGTACACA	0.438													16	104					0	0	0	0	C	25754408	C	C	25754408	3	2	147	1	0	0	0	0	1	0	0	0	4811	1145	40	3	996	3	DTNB	2	25754408	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08		25754408	217444965	17	26926											
SOS1	6654	broad.mit.edu	37	chr2	39251221	39251221	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgaacattaagcaaagctgTtattgcttgttttaaacatt	13	16	6	6	0	0	1	0	1	0	0	0	1	0	1	0	0	5	5	0	0	6	7			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:39251221T>A	uc002rrk.3	-	9	1173	c.1132A>T	c.(1132-1134)ACA>TCA	p.T378S	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_5'UTR|SOS1_uc002rrl.2_Missense_Mutation_p.T110S	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	378	DH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				AGCAAAGCTGTTATTGCTTGT	0.303									Noonan_syndrome				4	49					0	0	0	0	A	39251221	A	A	39251221	3	1	147	1	0	0	0	0	1	0	0	0	15000	1725	60	5	2929	5	SOS1	2	39251221	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08	13496813	39251221	203948152	18	26927											
SLC8A1	6546	broad.mit.edu	37	chr2	40397431	40397431	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatgagtacctgcaatggtGattacagtagagagaatcgg	15	9	12	5	1	0	4	0	2	0	2	1	5	0	4	1	2	3	3	1	2	6	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:40397431G>A	uc002rrx.2	-	6	2052	c.2028C>T	c.(2026-2028)ATC>ATT	p.I676I	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Silent_p.I671I|SLC8A1_uc002rrz.2_Silent_p.I663I|SLC8A1_uc002rsa.2_Intron|SLC8A1_uc002rsd.3_Intron|SLC8A1_uc002rsb.1_Silent_p.I668I	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	676	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CTGCAATGGTGATTACAGTAG	0.433													8	56					0	0	0	0	A	40397431	A	A	40397431	2	1	147	1	0	0	0	0	0	0	0	1	14770	1280	45	2		2	SLC8A1	2	40397431	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08	1146210	40397431	202801942	19	26928											
RGPD4	285190	broad.mit.edu	37	chr2	108487680	108487680	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tatttagatttgatgctgagGtaaggcagtggaaagaaagg	14	11	14	2	0	0	4	0	2	0	2	0	5	0	5	0	4	1	3	0	4	5	5	rs2919157		TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:108487680G>A	uc010ywk.1	+	20	3302	c.3220G>A	c.(3220-3222)GTA>ATA	p.V1074I	RGPD4_uc002tdu.2_Missense_Mutation_p.V261I|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1074	RanBD1 1.				intracellular transport		binding			skin(2)	2						TGATGCTGAGGTAAGGCAGTG	0.383													71	513					0	0	0	0	A	108487680	A	A	108487680	3	1	147	1	0	0	0	0	1	0	0	0	13353	1261	44	4	3298	4	RGPD4	2	108487680	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	68090249	108487680	134711693	20	26929											
SULT1C2	6819	broad.mit.edu	37	chr2	108924864	108924864	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccagaatgagaggtttgatGaaatctatagaagaaagatg	17	9	11	4	0	1	7	0	3	1	5	1	8	1	7	1	1	0	1	1	1	6	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:108924864G>A	uc002tdy.2	+	8	1288	c.835G>A	c.(835-837)GAA>AAA	p.E279K	SULT1C2_uc002tdx.2_Missense_Mutation_p.E290K|SULT1C2_uc010ywq.1_Missense_Mutation_p.E293K	NM_001056	NP_001047	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 1	279					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			ovary(1)	1						GAGGTTTGATGAAATCTATAG	0.413													9	86					0	0	0	0	A	108924864	A	A	108924864	3	1	147	1	0	0	0	0	1	0	0	0	15443	1291	45	2	960	2	SULT1C2	2	108924864	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	437184	108924864	134274509	21	26930											
ERCC3	2071	broad.mit.edu	37	chr2	128029027	128029027	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agatcaaacgaagtgtcaccTacctacagaaacaagttgga	17	7	8	9	1	2	2	2	0	0	2	2	4	2	3	2	1	4	1	2	1	6	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:128029027T>A	uc002toh.1	-	12	1925	c.1830A>T	c.(1828-1830)GTA>GTT	p.V610V	ERCC3_uc002toe.1_Silent_p.V365V|ERCC3_uc002tof.1_Silent_p.V546V|ERCC3_uc002tog.1_Silent_p.V546V	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	610	Helicase C-terminal.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		AAGTGTCACCTACCTACAGAA	0.413			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				8	118					0	0	0	0	A	128029027	A	A	128029027	2	1	147	1	0	0	0	0	0	0	0	1	5238	1509	53	5		5	ERCC3	2	128029027	Silent	SNP	T	TCGA-CR-7377-01A-11D-2012-08	19104163	128029027	115170346	22	26931											
SPHKAP	80309	broad.mit.edu	37	chr2	228882145	228882145	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagcagtaactcaaatcctCtcccttcattttccatctgg	9	13	4	15	0	4	0	2	0	2	0	7	0	6	0	4	1	2	2	4	1	2	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:228882145C>G	uc002vpq.2	-	7	3472	c.3425G>C	c.(3424-3426)AGA>ACA	p.R1142T	SPHKAP_uc002vpp.2_Missense_Mutation_p.R1142T|SPHKAP_uc010zlx.1_Missense_Mutation_p.R1142T	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1142						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTCAAATCCTCTCCCTTCATT	0.527													9	46					0	0	0	0	G	228882145	G	G	228882145	3	3	147	1	0	0	0	0	1	0	0	0	15114	913	32	2	1701	2	SPHKAP	2	228882145	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	100853118	228882145	14317228	23	26932											
GIGYF2	26058	broad.mit.edu	37	chr2	233675989	233675989	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggttttggcccaacagcagaAagcagcactgtcttcccagc	10	8	10	13	0	1	1	0	0	1	1	2	1	2	1	2	2	5	4	2	2	2	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:233675989A>C	uc002vti.3	+	19	2271	c.1934A>C	c.(1933-1935)AAA>ACA	p.K645T	GIGYF2_uc010zmj.1_Missense_Mutation_p.K645T|GIGYF2_uc002vtg.2_Missense_Mutation_p.K639T|GIGYF2_uc002vtj.3_Missense_Mutation_p.K666T|GIGYF2_uc002vtk.3_Missense_Mutation_p.K645T|GIGYF2_uc002vth.3_Missense_Mutation_p.K639T|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.K476T|GIGYF2_uc002vtq.3_5'UTR	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	645	Gln-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		CAACAGCAGAAAGCAGCACTG	0.423													7	60					0	0	0	0	C	233675989	C	C	233675989	3	2	147	1	0	0	0	0	1	0	0	0	6415	14	1	5	2062	5	GIGYF2	2	233675989	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	4793844	233675989	9523384	24	26933											
ESPNL	339768	broad.mit.edu	37	chr2	239040108	239040108	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccgccgggcctggaccgacgGcttcgaggacatcaaagccc	8	4	13	16	5	1	0	1	0	0	0	2	4	1	2	5	4	1	1	5	4	1	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr2:239040108G>A	uc002vxq.3	+	9	2863	c.2753G>A	c.(2752-2754)GGC>GAC	p.G918D	ESPNL_uc010fyw.2_Missense_Mutation_p.G614D	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	918										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		TGGACCGACGGCTTCGAGGAC	0.706													3	35					0	0	0	0	A	239040108	A	A	239040108	3	1	147	1	0	0	0	0	1	0	0	0	5279	1203	42	4	2787	4	ESPNL	2	239040108	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	5364119	239040108	4159265	25	26934											
LRRN1	57633	broad.mit.edu	37	chr3	3887531	3887531	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatgttctgtgccatgccGcccgaatataaagggcacca	10	9	9	13	2	1	0	0	0	1	0	2	1	2	0	5	1	2	2	5	1	4	3	rs147557425	by1000genomes	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:3887531G>C	uc003bpt.3	+	2	1967	c.1206G>C	c.(1204-1206)CCG>CCC	p.P402P	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	402	LRRCT.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		GTGCCATGCCGCCCGAATATA	0.483													26	79					0	0	0	0	C	3887531	C	C	3887531	2	2	147	1	0	0	0	0	0	0	0	1	9084	1074	38	3		3	LRRN1	3	3887531	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08		3887531	194134899	26	26935											
SLC6A11	6538	broad.mit.edu	37	chr3	10974928	10974928	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctttgagtgcatctgcatcgGctgggtgtatggtgagtagc	6	13	15	7	1	1	2	0	2	1	0	2	2	1	2	0	3	3	5	0	3	2	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:10974928G>A	uc003bvz.2	+	11	1497	c.1463G>A	c.(1462-1464)GGC>GAC	p.G488D		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	488	Helical; Name=10; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		ATCTGCATCGGCTGGGTGTAT	0.582													4	171					0	0	0	0	A	10974928	A	A	10974928	3	1	147	1	0	0	0	0	1	0	0	0	14738	1203	42	4	1505	4	SLC6A11	3	10974928	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	7087397	10974928	187047502	27	26936											
MITF	4286	broad.mit.edu	37	chr3	70008500	70008500	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agttgcaacgagaacagcaaCgcgcaaaagaacttgaaaac	19	4	9	9	3	0	3	0	1	0	2	0	4	0	3	0	0	7	4	0	0	8	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:70008500C>T	uc003dnz.2	+	9	1206	c.1090C>T	c.(1090-1092)CGC>TGC	p.R364C	MITF_uc011bgb.1_Missense_Mutation_p.R312C|MITF_uc003doa.2_Missense_Mutation_p.R363C|MITF_uc003dob.2_Missense_Mutation_p.R348C|MITF_uc003dod.2_Missense_Mutation_p.R339C|MITF_uc003doe.2_Missense_Mutation_p.R257C|MITF_uc003dof.2_Missense_Mutation_p.R263C	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	370					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		AGAACAGCAACGCGCAAAAGA	0.463			A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						8	35					0	0	0	0	T	70008500	T	T	70008500	3	4	147	1	0	0	0	0	1	0	0	0	9649	536	19	1	1363	1	MITF	3	70008500	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	59033572	70008500	128013930	28	26937											
OR5H14	403273	broad.mit.edu	37	chr3	97868271	97868271	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctgacagagtttgttctCacaggatttttatatcaacc	10	16	7	8	0	2	2	2	1	1	1	3	3	2	3	1	1	2	3	1	1	3	7			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:97868271C>T	uc003dsg.1	+	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGTTTGTTCTCACAGGATTTT	0.403													18	167					0	0	0	0	T	97868271	T	T	97868271	2	4	147	1	0	0	0	0	0	0	0	1	11214	813	29	2		2	OR5H14	3	97868271	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	27859771	97868271	100154159	29	26938											
ABI3BP	25890	broad.mit.edu	37	chr3	100469363	100469363	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cattttccaggaattgtagtCccacattcataccactgaac	12	12	5	12	0	1	1	1	1	0	0	3	2	3	2	3	1	2	1	3	1	4	6			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:100469363C>T	uc003dun.2	-	35	3289	c.3204G>A	c.(3202-3204)GGG>GGA	p.G1068G	ABI3BP_uc003duj.2_Silent_p.G648G|ABI3BP_uc003duk.2_Silent_p.G777G|ABI3BP_uc003dul.2_Silent_p.G898G|ABI3BP_uc011bhd.1_Silent_p.G1022G|ABI3BP_uc003dum.2_Silent_p.G479G	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	1068						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						GAATTGTAGTCCCACATTCAT	0.388													9	130					0	0	0	0	T	100469363	T	T	100469363	2	4	147	1	0	0	0	0	0	0	0	1	91	842	30	2		2	ABI3BP	3	100469363	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	2601092	100469363	97553067	30	26939											
MORC1	27136	broad.mit.edu	37	chr3	108746688	108746688	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttttttgatggtgatattgtGctcatggtgcccagtgggat	6	17	13	5	0	1	2	1	2	0	0	1	3	1	3	1	3	2	1	1	3	1	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:108746688G>A	uc003dxl.2	-	17	1701	c.1614C>T	c.(1612-1614)AGC>AGT	p.S538S	MORC1_uc011bhn.1_Silent_p.S538S	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	538					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						GTGATATTGTGCTCATGGTGC	0.398													17	79					0	0	0	0	A	108746688	A	A	108746688	2	1	147	1	0	0	0	0	0	0	0	1	9754	1310	46	4		4	MORC1	3	108746688	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08	8277325	108746688	89275742	31	26940											
DPPA2	151871	broad.mit.edu	37	chr3	109023367	109023367	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tattatcttctatgcctgggGatgggaaaatgcaggcaggt	10	12	13	6	0	2	0	0	0	2	0	2	2	2	2	1	5	2	2	1	5	5	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:109023367G>T	uc003dxo.2	-	7	1056	c.809C>A	c.(808-810)TCC>TAC	p.S270Y		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	270						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						TATGCCTGGGGATGGGAAAAT	0.478													17	53					9.16793e-09	1.12467e-08	1	0	T	109023367	T	T	109023367	3	4	147	1	0	0	0	0	1	0	0	0	4756	1174	41	2	95	2	DPPA2	3	109023367	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	276679	109023367	88999063	32	26941											
DPPA4	55211	broad.mit.edu	37	chr3	109047778	109047778	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacatattgtcttcaaggtgCgggggtggaaaattggaggc	11	10	15	5	1	2	0	1	0	1	0	2	2	2	2	0	6	2	0	0	6	5	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:109047778C>T	uc003dxq.3	-	6	892	c.837G>A	c.(835-837)CCG>CCA	p.P279P	DPPA4_uc011bho.1_Missense_Mutation_p.A181T	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	279						nucleus	protein binding			upper_aerodigestive_tract(1)	1						CTTCAAGGTGCGGGGGTGGAA	0.463													12	40					0	0	0	0	T	109047778	T	T	109047778	2	4	147	1	0	0	0	0	0	0	0	1	4758	755	27	1		1	DPPA4	3	109047778	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	24411	109047778	88974652	33	26942											
GOLGB1	2804	broad.mit.edu	37	chr3	121414052	121414052	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctaggttagcttgtttaGatacattaccttctatctga	9	17	6	9	0	3	2	0	1	3	1	3	2	3	2	2	1	3	3	2	1	6	9			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:121414052G>C	uc003eei.3	-	13	5429	c.5303C>G	c.(5302-5304)TCT>TGT	p.S1768C	GOLGB1_uc010hrc.2_Missense_Mutation_p.S1773C|GOLGB1_uc003eej.3_Missense_Mutation_p.S1734C|GOLGB1_uc011bjm.1_Missense_Mutation_p.S1654C|GOLGB1_uc010hrd.1_Missense_Mutation_p.S1732C	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1768	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AGCTTGTTTAGATACATTACC	0.393													20	226					0	0	0	0	C	121414052	C	C	121414052	3	2	147	1	0	0	0	0	1	0	0	0	6602	942	33	2	4516	2	GOLGB1	3	121414052	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	12366274	121414052	76608378	34	26943											
PLCH1	23007	broad.mit.edu	37	chr3	155314050	155314050	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcactcttcctagagggtCgccatcggaggcgtgtccgg	5	10	13	13	4	2	1	1	0	2	1	7	2	4	2	3	4	0	0	3	4	1	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:155314050C>T	uc011bok.1	-	2	438	c.161G>A	c.(160-162)CGA>CAA	p.R54Q	PLCH1_uc011boj.1_Missense_Mutation_p.R54Q|PLCH1_uc011bol.1_Missense_Mutation_p.R36Q	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	54	PH.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCTAGAGGGTCGCCATCGGAG	0.498													55	195					0	0	0	0	T	155314050	T	T	155314050	3	4	147	1	0	0	0	0	1	0	0	0	12092	884	31	1	5023	1	PLCH1	3	155314050	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	33899998	155314050	42708380	35	26944											
SI	6476	broad.mit.edu	37	chr3	164760860	164760860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcttacttcatatccgtcaGaattatggtttctggaaaat	11	16	6	8	1	4	1	2	0	2	1	5	2	5	2	1	2	1	1	1	2	6	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr3:164760860G>A	uc003fei.2	-	17	2053	c.1991C>T	c.(1990-1992)TCT>TTT	p.S664F		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	664	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATATCCGTCAGAATTATGGTT	0.358										HNSCC(35;0.089)			14	73					0	0	0	0	A	164760860	A	A	164760860	3	1	147	1	0	0	0	0	1	0	0	0	14362	942	33	2	3620	2	SI	3	164760860	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	9446810	164760860	33261570	36	26945											
CCDC149	91050	broad.mit.edu	37	chr4	24854761	24854761	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcttctcccagatgtttaTttcggtcctgagaatctctc	6	18	6	11	1	3	2	0	1	3	2	8	3	4	2	2	1	0	1	2	1	2	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr4:24854761T>C	uc011bxr.1	-	5	449	c.305A>G	c.(304-306)AAT>AGT	p.N102S	CCDC149_uc003grc.2_Missense_Mutation_p.N102S|CCDC149_uc003grb.2_RNA|CCDC149_uc003grd.2_Missense_Mutation_p.N102S|CCDC149_uc003gre.2_Missense_Mutation_p.N47S|CCDC149_uc011bxq.1_5'UTR	NM_173463	NP_775734	B4DZG3	B4DZG3_HUMAN	coiled-coil domain containing 149 isoform 1	102											0		Breast(46;0.173)				CAGATGTTTATTTCGGTCCTG	0.413													16	83					0	0	0	0	C	24854761	C	C	24854761	3	2	147	1	0	0	0	0	1	0	0	0	2795	1493	52	5	1324	5	CCDC149	4	24854761	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08		24854761	166299515	37	26946											
PLK4	10733	broad.mit.edu	37	chr4	128807211	128807211	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtagtattggcagattatgAaatgccatcttttttgtcaa	12	16	8	5	0	2	2	1	1	1	1	2	2	2	2	1	1	1	3	1	1	5	7			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr4:128807211A>T	uc003ifo.2	+	5	931	c.686A>T	c.(685-687)GAA>GTA	p.E229V	PLK4_uc011cgs.1_Missense_Mutation_p.E197V|PLK4_uc011cgt.1_Missense_Mutation_p.E188V	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	229	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GCAGATTATGAAATGCCATCT	0.398													10	131					0	0	0	0	T	128807211	T	T	128807211	3	4	147	1	0	0	0	0	1	0	0	0	12153	246	9	5	704	5	PLK4	4	128807211	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	103952450	128807211	62347065	38	26947											
ZNF827	152485	broad.mit.edu	37	chr4	146807157	146807157	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtggggagatcccttgaCatctgggtctgggatctcct	6	11	15	9	0	3	2	0	1	3	1	5	5	4	3	2	5	0	0	2	5	0	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr4:146807157C>T	uc003ikn.2	-	4	1468	c.1420G>A	c.(1420-1422)GTC>ATC	p.V474I	ZNF827_uc003ikm.2_Missense_Mutation_p.V474I|ZNF827_uc010iox.2_Missense_Mutation_p.V124I	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	474					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					GATCCCTTGACATCTGGGTCT	0.567													9	65					0	0	0	0	T	146807157	T	T	146807157	3	4	147	1	0	0	0	0	1	0	0	0	18247	478	17	4	1853	4	ZNF827	4	146807157	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	17999946	146807157	44347119	39	26948											
FSTL5	56884	broad.mit.edu	37	chr4	162306902	162306902	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgtatcgtagggtttttaGgcatctccaacccaaatgac	11	13	8	9	1	1	1	0	1	1	0	3	1	1	1	2	2	1	4	2	2	5	6			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr4:162306902G>A	uc003iqh.2	-	16	2977	c.2541C>T	c.(2539-2541)GCC>GCT	p.A847A	FSTL5_uc003iqi.2_Silent_p.A846A|FSTL5_uc010iqv.2_Silent_p.A837A|uc010iqu.1_Intron	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	847						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		AGGGTTTTTAGGCATCTCCAA	0.338													10	81					0	0	0	0	A	162306902	A	A	162306902	2	1	147	1	0	0	0	0	0	0	0	1	6114	987	35	4		4	FSTL5	4	162306902	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08	15499745	162306902	28847374	40	26949											
ACSL1	2180	broad.mit.edu	37	chr4	185681655	185681655	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataattttcaaggtgccattCtgttgatcagaggggagggg	10	12	14	5	0	3	2	2	1	1	1	3	3	3	3	1	5	1	1	1	5	2	5	rs111329654		TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr4:185681655C>T	uc003iww.2	-	18	1933	c.1639_splice	c.e18-1	p.N547_splice	ACSL1_uc011ckm.1_Splice_Site_p.N376_splice|ACSL1_uc003iwt.1_Splice_Site_p.N547_splice|ACSL1_uc003iwu.1_Splice_Site_p.N547_splice|ACSL1_uc011ckn.1_Splice_Site_p.N513_splice|ACSL1_uc003iws.1_Splice_Site_p.N107_splice	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1						digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGGTGCCATTCTGTTGATCAG	0.403													44	337					0	0	0	0	T	185681655	T	T	185681655	5	4	147	1	0	0	0	0	0	0	1	0	177	927	32	2	474	2	ACSL1	4	185681655	Splice_Site	SNP	C	TCGA-CR-7377-01A-11D-2012-08	23374753	185681655	5472621	41	26950											
DHX29	54505	broad.mit.edu	37	chr5	54565331	54565331	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgcaaggtgttggcccaaCggagtcagtttaggctcatt	8	11	13	9	1	2	0	2	0	0	0	2	1	2	1	1	4	2	5	1	4	3	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr5:54565331C>T	uc003jpx.2	-	21	3324	c.3204G>A	c.(3202-3204)CCG>CCA	p.P1068P	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	1068							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GTTGGCCCAACGGAGTCAGTT	0.443													7	32					0	0	0	0	T	54565331	T	T	54565331	2	4	147	1	0	0	0	0	0	0	0	1	4525	523	19	1		1	DHX29	5	54565331	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08		54565331	126349929	42	26951											
IPO11	51194	broad.mit.edu	37	chr5	61779883	61779883	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cataagattaagatggcattCttcacatatcctactttgac	13	14	5	9	0	2	3	1	1	1	2	3	3	3	3	1	1	1	1	1	1	4	7			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr5:61779883C>G	uc003jtc.2	+	11	1258	c.1068C>G	c.(1066-1068)TTC>TTG	p.F356L	IPO11_uc011cqr.1_Missense_Mutation_p.F396L|IPO11_uc003jtb.1_Missense_Mutation_p.F356L	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	356	HEAT 3.					cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		AGATGGCATTCTTCACATATC	0.353													9	62					0	0	0	0	G	61779883	G	G	61779883	3	3	147	1	0	0	0	0	1	0	0	0	7832	912	32	2	1230	2	IPO11	5	61779883	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	7214552	61779883	119135377	43	26952											
PCDHB14	56122	broad.mit.edu	37	chr5	140603276	140603276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcacgtgaagcccgggtaGtgtctgatgataataaaaag	13	10	11	7	2	2	3	1	3	1	0	2	3	2	3	1	1	1	1	1	1	6	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr5:140603276G>A	uc003ljb.2	+	1	199	c.199G>A	c.(199-201)GTG>ATG	p.V67M	PCDHB14_uc011dal.1_Intron	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	67	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCCCGGGTAGTGTCTGATGA	0.493													14	106					0	0	0	0	A	140603276	A	A	140603276	3	1	147	1	0	0	0	0	1	0	0	0	11593	1029	36	4	201	4	PCDHB14	5	140603276	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	78823393	140603276	40311984	44	26953											
POU4F3	5459	broad.mit.edu	37	chr5	145719962	145719962	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtgagagtctggttctgcaaCcagagacagaaacagaaacg	15	6	12	8	1	2	4	0	1	2	4	2	6	2	4	1	1	4	2	1	1	3	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr5:145719962C>T	uc003loa.2	+	2	1061	c.972C>T	c.(970-972)AAC>AAT	p.N324N		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	324	Homeobox.				sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTTCTGCAACCAGAGACAGA	0.552													7	74					0	0	0	0	T	145719962	T	T	145719962	2	4	147	1	0	0	0	0	0	0	0	1	12335	506	18	4		4	POU4F3	5	145719962	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	5116686	145719962	35195298	45	26954											
KIAA0319	9856	broad.mit.edu	37	chr6	24564520	24564520	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgtacaccccctccaccaGattcgtaagctgcagagcca	11	7	8	15	1	0	2	0	0	0	2	2	2	1	2	5	0	4	4	5	0	2	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:24564520G>C	uc011djo.1	-	15	2578	c.2341C>G	c.(2341-2343)CTG>GTG	p.L781V	KIAA0319_uc011djp.1_Missense_Mutation_p.L736V|KIAA0319_uc003neh.1_Missense_Mutation_p.L781V|KIAA0319_uc011djq.1_Missense_Mutation_p.L772V|KIAA0319_uc011djr.1_Missense_Mutation_p.L781V|KIAA0319_uc010jpt.1_Missense_Mutation_p.L192V	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	781	PKD 5.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CCCTCCACCAGATTCGTAAGC	0.567													14	86					0	0	0	0	C	24564520	C	C	24564520	3	2	147	1	0	0	0	0	1	0	0	0	8207	933	33	2	905	2	KIAA0319	6	24564520	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08		24564520	146550547	46	26955											
HIST1H2BE	8344	broad.mit.edu	37	chr6	26184294	26184294	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaacaagcgctcgaccatcAcctccagggagatccagacg	13	4	9	15	3	1	2	1	0	0	2	4	4	3	2	4	1	2	1	4	1	2	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:26184294A>G	uc003ngt.2	+	1	271	c.271A>G	c.(271-273)ACC>GCC	p.T91A		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	91					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CTCGACCATCACCTCCAGGGA	0.607													11	134					0	0	0	0	G	26184294	G	G	26184294	3	3	147	1	0	0	0	0	1	0	0	0	7183	159	6	5	273	5	HIST1H2BE	6	26184294	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	1619774	26184294	144930773	47	26956											
TRIM15	89870	broad.mit.edu	37	chr6	30140093	30140093	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttccctttctttgccgtctgGaaaaaaggttcctgccttac	7	15	7	12	1	2	0	0	0	2	0	4	1	4	1	4	2	3	1	4	2	4	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:30140093G>A	uc010jrx.2	+	7	1844	c.1365G>A	c.(1363-1365)TGG>TGA	p.W455*		NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15	455	B30.2/SPRY.				mesodermal cell fate determination	intracellular	zinc ion binding				0						TTGCCGTCTGGAAAAAAGGTT	0.637													10	54					0	0	0	0	A	30140093	A	A	30140093	4	1	147	1	0	0	0	0	0	1	0	0	16557	1183	41	2	1391	2	TRIM15	6	30140093	Nonsense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	3955799	30140093	140974974	48	26957											
GLO1	2739	broad.mit.edu	37	chr6	38649810	38649810	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatcaggtttcttcacaaaTttgactcccagttcttcaaa	11	15	4	11	0	6	1	4	1	2	0	7	1	7	1	1	1	0	2	1	1	2	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:38649810T>C	uc003ooc.2	-	5	566	c.444A>G	c.(442-444)AAA>AAG	p.K148K		NM_006708	NP_006699	Q04760	LGUL_HUMAN	glyoxalase I	148					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			ovary(1)	1					Glutathione(DB00143)	TCTTCACAAATTTGACTCCCA	0.413													10	75					0	0	0	0	C	38649810	C	C	38649810	2	2	147	1	0	0	0	0	0	0	0	1	6486	1490	52	5		5	GLO1	6	38649810	Silent	SNP	T	TCGA-CR-7377-01A-11D-2012-08	8509717	38649810	132465257	49	26958											
ZNF318	24149	broad.mit.edu	37	chr6	43322834	43322834	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagtctaattggggcagaTggggctgatggcaacatgca	11	8	16	6	0	1	2	0	1	1	1	1	3	1	3	0	6	2	4	0	6	3	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:43322834T>C	uc003oux.2	-	4	2316	c.2238A>G	c.(2236-2238)CCA>CCG	p.P746P	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	746					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TTGGGGCAGATGGGGCTGATG	0.512													17	81					0	0	0	0	C	43322834	C	C	43322834	2	2	147	1	0	0	0	0	0	0	0	1	17903	1451	51	5		5	ZNF318	6	43322834	Silent	SNP	T	TCGA-CR-7377-01A-11D-2012-08	4673024	43322834	127792233	50	26959											
CRISP3	10321	broad.mit.edu	37	chr6	49704206	49704206	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttgggtggttaacaaagcAgtaaaagcgggatcctaagg	13	9	14	5	1	0	0	0	0	0	0	1	1	1	1	1	4	3	4	1	4	5	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:49704206A>G	uc003ozs.2	-	3	102	c.87T>C	c.(85-87)ACT>ACC	p.T29T		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	29					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TTAACAAAGCAGTAAAAGCGG	0.378													23	190					0	0	0	0	G	49704206	G	G	49704206	2	3	147	1	0	0	0	0	0	0	0	1	3896	175	7	5		5	CRISP3	6	49704206	Silent	SNP	A	TCGA-CR-7377-01A-11D-2012-08	6381372	49704206	121410861	51	26960											
COL21A1	81578	broad.mit.edu	37	chr6	55925556	55925556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacctcttattacatctgtgCaaacttgtcgaataaattgt	12	16	5	8	1	2	0	0	0	2	0	3	1	2	0	1	0	4	1	1	0	7	6			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:55925556C>T	uc003pcs.2	-	27	2622	c.2390G>A	c.(2389-2391)TGC>TAC	p.C797Y	COL21A1_uc010jzz.2_Missense_Mutation_p.C182Y|COL21A1_uc011dxg.1_Missense_Mutation_p.C170Y|COL21A1_uc011dxh.1_Missense_Mutation_p.C182Y|COL21A1_uc003pcr.2_Missense_Mutation_p.C154Y	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	797					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TACATCTGTGCAAACTTGTCG	0.299													7	66					0	0	0	0	T	55925556	T	T	55925556	3	4	147	1	0	0	0	0	1	0	0	0	3695	710	25	4	499	4	COL21A1	6	55925556	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	6221350	55925556	115189511	52	26961											
FAM135A	57579	broad.mit.edu	37	chr6	71232224	71232224	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaattttttaggtacgcagAttttctgaggcattcttttg	8	18	10	5	1	2	2	0	1	2	1	2	3	2	3	0	3	1	3	0	3	3	9			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:71232224A>G	uc003pfj.2	+	11	1171	c.1038A>G	c.(1036-1038)AGA>AGG	p.R346R	FAM135A_uc003pfi.2_Silent_p.R346R|FAM135A_uc003pfh.2_Silent_p.R329R|FAM135A_uc003pfk.2_Silent_p.R372R|FAM135A_uc003pfl.2_Silent_p.R209R|FAM135A_uc003pfn.2_5'Flank|FAM135A_uc003pfo.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	346										central_nervous_system(1)	1						AGGTACGCAGATTTTCTGAGG	0.348													14	144					0	0	0	0	G	71232224	G	G	71232224	2	3	147	1	0	0	0	0	0	0	0	1	5476	330	12	5		5	FAM135A	6	71232224	Silent	SNP	A	TCGA-CR-7377-01A-11D-2012-08	15306668	71232224	99882843	53	26962											
SIM1	6492	broad.mit.edu	37	chr6	100838427	100838427	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcatgcttgtcaaaatacTgccggtgagagccaaagcag	14	7	11	9	1	1	1	1	1	0	1	1	2	1	1	2	1	6	3	2	1	5	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:100838427T>C	uc003pqj.3	-	11	2318	c.2111A>G	c.(2110-2112)CAG>CGG	p.Q704R	SIM1_uc010kcu.2_Missense_Mutation_p.Q704R	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	704	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GTCAAAATACTGCCGGTGAGA	0.448													11	91					0	0	0	0	C	100838427	C	C	100838427	3	2	147	1	0	0	0	0	1	0	0	0	14388	1580	55	5	193	5	SIM1	6	100838427	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08	29606203	100838427	70276640	54	26963											
SIM1	6492	broad.mit.edu	37	chr6	100901656	100901656	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctggagcagatgggagccCagttctcggccaacgttgtc	8	8	13	12	2	1	1	0	0	1	1	3	3	1	3	3	3	3	3	3	3	1	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:100901656C>T	uc003pqj.3	-	2	447	c.240G>A	c.(238-240)CTG>CTA	p.L80L	SIM1_uc010kcu.2_Silent_p.L80L	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	80	PAS 1.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GATGGGAGCCCAGTTCTCGGC	0.587													15	92					0	0	0	0	T	100901656	T	T	100901656	2	4	147	1	0	0	0	0	0	0	0	1	14388	581	21	4		4	SIM1	6	100901656	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	63229	100901656	70213411	55	26964											
TMEM200A	114801	broad.mit.edu	37	chr6	130762312	130762312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttatgccccctttgctctctGacagctctgtgtctgtcttt	3	18	7	13	0	4	1	0	1	4	0	5	1	4	1	2	0	3	2	2	0	1	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:130762312G>A	uc003qca.2	+	3	1616	c.745G>A	c.(745-747)GAC>AAC	p.D249N	TMEM200A_uc010kfh.2_Missense_Mutation_p.D249N|TMEM200A_uc010kfi.2_Missense_Mutation_p.D249N|TMEM200A_uc003qcb.2_Missense_Mutation_p.D249N	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	249	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TTTGCTCTCTGACAGCTCTGT	0.463													10	82					0	0	0	0	A	130762312	A	A	130762312	3	1	147	1	0	0	0	0	1	0	0	0	16189	1290	45	2	747	2	TMEM200A	6	130762312	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	29860656	130762312	40352755	56	26965											
SGK1	6446	broad.mit.edu	37	chr6	134638658	134638658	+	Translation_Start_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcacccgcctggttagtgcaTatctgtttccccggtttacc	5	13	9	14	2	1	0	0	0	1	0	2	0	2	0	5	2	2	5	5	2	3	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:134638658T>C	uc003qeo.3	-	1	539	c.-59A>G	c.(-61--57)ATATG>ATGTG		SGK1_uc003qep.2_Translation_Start_Site	NM_001143676	NP_001137148	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1 isoform						apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(3)|stomach(1)|lung(1)|central_nervous_system(1)	6	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		GGTTAGTGCATATCTGTTTCC	0.493													15	67					0	0	0	0	C	134638658	C	C	134638658	1	2	147	1	0	0	0	0	0	0	0	0	14272	1421	49	5		5	SGK1	6	134638658	Translation_Start_Site	SNP	T	TCGA-CR-7377-01A-11D-2012-08	3876346	134638658	36476409	57	26966											
AHI1	54806	broad.mit.edu	37	chr6	135778701	135778701	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttttaccattgggtgagaaAtcataaaatctgacttaagt	14	15	7	5	0	2	2	1	2	1	1	2	3	2	2	1	1	1	0	1	1	5	6			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr6:135778701A>G	uc003qgi.2	-	9	1466	c.1082T>C	c.(1081-1083)ATT>ACT	p.I361T	AHI1_uc003qgh.2_Missense_Mutation_p.I361T|AHI1_uc003qgj.2_Missense_Mutation_p.I361T|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Missense_Mutation_p.I361T	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	361						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TGGGTGAGAAATCATAAAATC	0.358													15	64					0	0	0	0	G	135778701	G	G	135778701	3	3	147	1	0	0	0	0	1	0	0	0	413	101	4	5	2649	5	AHI1	6	135778701	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	1140043	135778701	35336366	58	26967											
TMEM106B	54664	broad.mit.edu	37	chr7	12258148	12258148	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agattaaggccaagaagaacGtaagtgattctaagaatatg	18	9	10	4	1	1	5	0	1	1	4	1	5	1	5	1	1	1	1	1	1	8	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:12258148G>A	uc011jxk.1	+	4	681	c.281_splice	c.e4+1	p.T94_splice	TMEM106B_uc003ssh.2_Splice_Site_p.T94_splice	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B							integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		CAAGAAGAACGTAAGTGATTC	0.279													10	30					0	0	0	0	A	12258148	A	A	12258148	5	1	147	1	0	0	0	0	0	0	1	0	16087	1159	40	1	288	1	TMEM106B	7	12258148	Splice_Site	SNP	G	TCGA-CR-7377-01A-11D-2012-08		12258148	146880515	59	26968											
ANKMY2	57037	broad.mit.edu	37	chr7	16640498	16640498	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatcttcaggattggaatccTtttgagagatacctacttca	12	14	7	8	0	3	2	2	1	1	1	4	5	4	4	2	2	2	0	2	2	4	7			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:16640498T>C	uc003sti.2	-	10	1414	c.1214A>G	c.(1213-1215)AAG>AGG	p.K405R	ANKMY2_uc010ktz.2_RNA	NM_020319	NP_064715	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	405						cilium	zinc ion binding			central_nervous_system(1)	1	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		ATTGGAATCCTTTTGAGAGAT	0.423													15	52					0	0	0	0	C	16640498	C	C	16640498	3	2	147	1	0	0	0	0	1	0	0	0	635	1609	56	5	115	5	ANKMY2	7	16640498	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08	4382350	16640498	142498165	60	26969											
BMPER	168667	broad.mit.edu	37	chr7	34118721	34118721	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtgcgctggaacggctcgcGcatcgcgctcccctgccgcg	3	6	14	18	9	0	0	0	0	0	0	3	1	1	1	3	2	3	4	3	2	1	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:34118721G>A	uc011kap.1	+	12	1445	c.1331G>A	c.(1330-1332)CGC>CAC	p.R444H		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	444	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						AACGGCTCGCGCATCGCGCTC	0.662													4	102					0	0	0	0	A	34118721	A	A	34118721	3	1	147	1	0	0	0	0	1	0	0	0	1471	1087	38	1	1377	1	BMPER	7	34118721	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	17478223	34118721	125019942	61	26970											
ELMO1	9844	broad.mit.edu	37	chr7	37264509	37264509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtgtggaatgagctggcCgatggtgatctcctgcgcca	7	9	15	10	2	1	2	0	2	1	0	2	4	1	3	3	4	2	1	3	4	1	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:37264509C>T	uc003tfk.1	-	9	983	c.676G>A	c.(676-678)GGC>AGC	p.G226S	ELMO1_uc011kbc.1_Missense_Mutation_p.G130S|ELMO1_uc010kxg.1_Missense_Mutation_p.G226S	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	226					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						ATGAGCTGGCCGATGGTGATC	0.532													24	73					0	0	0	0	T	37264509	T	T	37264509	3	4	147	1	0	0	0	0	1	0	0	0	5089	652	23	1	1563	1	ELMO1	7	37264509	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	3145788	37264509	121874154	62	26971											
HECW1	23072	broad.mit.edu	37	chr7	43581558	43581558	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacaacatcacagacatcttAgacctcactttcactgttaa	15	11	3	12	0	4	2	3	0	1	2	4	2	4	2	1	0	2	1	1	0	4	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:43581558A>G	uc003tid.1	+	26	4814	c.4209A>G	c.(4207-4209)TTA>TTG	p.L1403L	HECW1_uc011kbi.1_Silent_p.L1369L	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1403	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CAGACATCTTAGACCTCACTT	0.378													13	65					0	0	0	0	G	43581558	G	G	43581558	2	3	147	1	0	0	0	0	0	0	0	1	7081	417	15	5		5	HECW1	7	43581558	Silent	SNP	A	TCGA-CR-7377-01A-11D-2012-08	6317049	43581558	115557105	63	26972											
DBNL	28988	broad.mit.edu	37	chr7	44089842	44089842	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggctctctttacctatgaAggcaacagcaatgacatccg	12	9	9	11	1	1	2	0	2	1	0	3	2	2	2	2	2	3	3	2	2	5	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:44089842A>C	uc003tjp.3	+	2	200	c.102A>C	c.(100-102)GAA>GAC	p.E34D	DBNL_uc003tjn.2_5'UTR|DBNL_uc003tjo.3_Missense_Mutation_p.E34D|DBNL_uc003tjr.3_5'UTR|DBNL_uc003tjq.3_Missense_Mutation_p.E34D|DBNL_uc011kbm.1_Missense_Mutation_p.E34D|DBNL_uc011kbn.1_Intron|DBNL_uc011kbo.1_5'UTR|DBNL_uc011kbp.1_Missense_Mutation_p.E34D|DBNL_uc011kbq.1_5'UTR|DBNL_uc011kbr.1_5'UTR|DBNL_uc011kbs.1_5'Flank	NM_001014436	NP_001014436	Q9UJU6	DBNL_HUMAN	drebrin-like isoform b	34	ADF-H.				activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			skin(1)	1						TTACCTATGAAGGCAACAGCA	0.542													3	121					0	0	0	0	C	44089842	C	C	44089842	3	2	147	1	0	0	0	0	1	0	0	0	4272	69	3	5	108	5	DBNL	7	44089842	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	508284	44089842	115048821	64	26973											
STEAP4	79689	broad.mit.edu	37	chr7	87913347	87913347	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ataatgctctctgtggattgCtatgattatgatgccagact	10	15	9	7	0	1	3	0	2	1	1	2	4	1	4	1	1	3	2	1	1	3	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:87913347C>T	uc003ujs.2	-	2	343	c.238G>A	c.(238-240)GCA>ACA	p.A80T	STEAP4_uc010lek.2_Missense_Mutation_p.A80T|STEAP4_uc003ujt.2_Missense_Mutation_p.A80T	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	80					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					CTGTGGATTGCTATGATTATG	0.413													11	94					0	0	0	0	T	87913347	T	T	87913347	3	4	147	1	0	0	0	0	1	0	0	0	15346	797	28	4	1157	4	STEAP4	7	87913347	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	43823505	87913347	71225316	65	26974											
ZNF804B	219578	broad.mit.edu	37	chr7	88965755	88965755	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccataacattttctcctgaCgaaatagataaatataagat	17	12	4	8	1	1	3	0	1	1	2	2	4	1	3	2	0	1	0	2	0	7	7	rs76889726	by1000genomes	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:88965755C>A	uc011khi.1	+	4	3997	c.3459C>A	c.(3457-3459)GAC>GAA	p.D1153E		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1153						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TTTCTCCTGACGAAATAGATA	0.418										HNSCC(36;0.09)			6	64					5.9392e-07	7.24376e-07	1	0	A	88965755	A	A	88965755	3	1	147	1	0	0	0	0	1	0	0	0	18238	535	19	3	3473	3	ZNF804B	7	88965755	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	1052408	88965755	70172908	66	26975											
ZAN	7455	broad.mit.edu	37	chr7	100358081	100358081	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttcctgggtgcaagcgggcGgtttgtggagctgcagacgg	5	9	18	9	3	0	1	0	0	0	1	1	2	1	2	1	5	4	4	1	5	1	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr7:100358081G>A	uc003uwj.2	+	19	3929	c.3764G>A	c.(3763-3765)CGG>CAG	p.R1255Q	ZAN_uc003uwk.2_Missense_Mutation_p.R1255Q|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_5'Flank	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1255	VWFD 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCAAGCGGGCGGTTTGTGGAG	0.587													14	95					0	0	0	0	A	100358081	A	A	100358081	3	1	147	1	0	0	0	0	1	0	0	0	17581	1116	39	1	3834	1	ZAN	7	100358081	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	11392326	100358081	58780582	67	26976											
CSMD1	64478	broad.mit.edu	37	chr8	4494972	4494972	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actgtatcctattgcgctcgCccgtgatgatgatccaggtg	7	12	11	11	3	0	3	0	3	0	0	3	3	2	3	3	1	1	2	3	1	2	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr8:4494972C>G	uc011kwk.1	-	2	584	c.194G>C	c.(193-195)GGC>GCC	p.G65A		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	65	Extracellular (Potential).|CUB 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATTGCGCTCGCCCGTGATGAT	0.473													18	93					0	0	0	0	G	4494972	G	G	4494972	3	3	147	1	0	0	0	0	1	0	0	0	3961	739	26	4	10589	4	CSMD1	8	4494972	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08		4494972	141869050	68	26977											
TRPA1	8989	broad.mit.edu	37	chr8	72938196	72938196	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgttatgtgtacttacgAataacatcccaccagatctg	12	14	6	9	1	1	1	0	0	1	1	2	2	2	1	2	0	3	2	2	0	5	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr8:72938196A>G	uc003xza.2	-	25	3225	c.3050T>C	c.(3049-3051)TTC>TCC	p.F1017S	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	1017	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TGTACTTACGAATAACATCCC	0.413													7	57					0	0	0	0	G	72938196	G	G	72938196	3	3	147	1	0	0	0	0	1	0	0	0	16644	260	9	5	321	5	TRPA1	8	72938196	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	68443224	72938196	73425826	69	26978											
CNGB3	54714	broad.mit.edu	37	chr8	87645051	87645051	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgaaaaacaatttcaaataAagtttgtggttctggaaggc	15	13	9	4	0	2	1	1	1	1	0	2	2	2	2	0	3	1	2	0	3	7	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr8:87645051A>C	uc003ydx.2	-	11	1295	c.1249T>G	c.(1249-1251)TTA>GTA	p.L417V	CNGB3_uc010maj.2_Missense_Mutation_p.L279V	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	417	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						ATTTCAAATAAAGTTTGTGGT	0.343													17	33					0	0	0	0	C	87645051	C	C	87645051	3	2	147	1	0	0	0	0	1	0	0	0	3616	11	1	5	1212	5	CNGB3	8	87645051	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	14706855	87645051	58718971	70	26979											
TRPM6	140803	broad.mit.edu	37	chr9	77370356	77370356	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctggctctggattcaactGgtcactctgagagcaggcat	8	11	11	11	0	4	1	2	1	2	1	5	3	5	2	1	4	2	3	1	4	1	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:77370356G>A	uc004ajl.1	-	28	5057	c.4819C>T	c.(4819-4821)CAG>TAG	p.Q1607*	TRPM6_uc004ajk.1_Nonsense_Mutation_p.Q1602*|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Nonsense_Mutation_p.Q558*|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Nonsense_Mutation_p.Q563*	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1607	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GGATTCAACTGGTCACTCTGA	0.428													3	81					0	0	0	0	A	77370356	A	A	77370356	4	1	147	1	0	0	0	0	0	1	0	0	16657	1357	47	4	1297	4	TRPM6	9	77370356	Nonsense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08		77370356	63843075	71	26980											
C9orf3	84909	broad.mit.edu	37	chr9	97535328	97535328	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcccataaacaacagggcccTttttccatgccaggagccac	11	8	7	15	0	0	0	0	0	0	0	2	1	2	1	5	2	4	0	5	2	3	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:97535328T>C	uc004ava.2	+	2	977	c.842T>C	c.(841-843)CTT>CCT	p.L281P	C9orf3_uc011lui.1_RNA|C9orf3_uc004aux.1_Missense_Mutation_p.L281P|C9orf3_uc004auy.2_Missense_Mutation_p.L281P|C9orf3_uc004auz.1_Missense_Mutation_p.L281P	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	281					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AACAGGGCCCTTTTTCCATGC	0.463													3	165					0	0	0	0	C	97535328	C	C	97535328	3	2	147	1	0	0	0	0	1	0	0	0	2489	1609	56	5	848	5	C9orf3	9	97535328	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08	20164972	97535328	43678103	72	26981											
ZNF510	22869	broad.mit.edu	37	chr9	99522337	99522337	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcattaaaggcttttccaaTtttattacattcaaaagctt	14	17	3	7	0	2	0	2	0	0	0	3	0	3	0	1	1	2	2	1	1	7	8			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:99522337T>C	uc004awn.1	-	6	964	c.775A>G	c.(775-777)ATT>GTT	p.I259V	ZNF510_uc004awo.1_Missense_Mutation_p.I259V	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	259	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				GCTTTTCCAATTTTATTACAT	0.303													6	50					0	0	0	0	C	99522337	C	C	99522337	3	2	147	1	0	0	0	0	1	0	0	0	18021	1493	52	5	1280	5	ZNF510	9	99522337	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08	1987009	99522337	41691094	73	26982											
TEX10	54881	broad.mit.edu	37	chr9	103070951	103070951	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccgtgctgtcaggaattaCagtcaacccaacctaagcag	13	7	9	12	1	2	0	2	0	0	0	2	1	2	1	3	1	6	2	3	1	5	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:103070951C>T	uc004bas.2	-	13	2511	c.2296G>A	c.(2296-2298)GTA>ATA	p.V766I	TEX10_uc011lvf.1_Missense_Mutation_p.V605I|TEX10_uc011lvg.1_Missense_Mutation_p.V769I	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	766						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TCAGGAATTACAGTCAACCCA	0.428													15	55					0	0	0	0	T	103070951	T	T	103070951	3	4	147	1	0	0	0	0	1	0	0	0	15838	478	17	4	505	4	TEX10	9	103070951	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	3548614	103070951	38142480	74	26983											
ZNF483	158399	broad.mit.edu	37	chr9	114305147	114305147	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaccagtgtgagaaagccttCccaacccattcactgctaag	13	8	7	13	0	1	1	1	1	0	1	2	2	2	1	4	0	4	1	4	0	4	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:114305147C>T	uc004bff.2	+	6	2156	c.1932C>T	c.(1930-1932)TTC>TTT	p.F644F	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	644	C2H2-type 8.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						AGAAAGCCTTCCCAACCCATT	0.388													9	48					0	0	0	0	T	114305147	T	T	114305147	2	4	147	1	0	0	0	0	0	0	0	1	18003	854	30	2		2	ZNF483	9	114305147	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	11234196	114305147	26908284	75	26984											
CRB2	286204	broad.mit.edu	37	chr9	126137517	126137517	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaggtccccactctcccCtgtgaagccaacccctgctt	6	10	7	18	0	2	1	1	1	1	0	4	1	3	1	7	1	3	1	7	1	2	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:126137517C>T	uc004bnx.1	+	12	3620	c.3528C>T	c.(3526-3528)CCC>CCT	p.P1176P		NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	1176	Extracellular (Potential).|EGF-like 15.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CCACTCTCCCCTGTGAAGCCA	0.627													8	91					0	0	0	0	T	126137517	T	T	126137517	2	4	147	1	0	0	0	0	0	0	0	1	3864	668	24	4		4	CRB2	9	126137517	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	11832370	126137517	15075914	76	26985											
NOTCH1	4851	broad.mit.edu	37	chr9	139400000	139400000	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctggcactcgggcagctCgcacgcctcctcgatcagcg	5	7	11	18	5	1	0	1	0	0	0	6	1	3	0	3	2	2	4	3	2	0	0	rs147841035	by1000genomes	TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr9:139400000C>A	uc004chz.2	-	25	4348	c.4348G>T	c.(4348-4350)GAG>TAG	p.E1450*	NOTCH1_uc004cia.1_Nonsense_Mutation_p.E680*	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1450	Extracellular (Potential).|LNR 1.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TCGGGCAGCTCGCACGCCTCC	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			7	47					0.000442599	0.000527618	1	0	A	139400000	A	A	139400000	4	1	147	1	0	0	0	0	0	1	0	0	10601	893	31	3	3359	3	NOTCH1	9	139400000	Nonsense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	13262483	139400000	1813431	77	26986											
PFKFB3	5209	broad.mit.edu	37	chr10	6255710	6255710	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggattggcgtccccacaaaAggtgagactgggtctcgagg	9	8	15	9	2	1	1	0	1	1	1	3	4	2	2	2	5	0	0	2	5	2	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr10:6255710A>G	uc001ije.2	+	2	585	c.201A>G	c.(199-201)AAA>AAG	p.K67K	PFKFB3_uc001ijd.2_Silent_p.K47K|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Silent_p.K81K|PFKFB3_uc001ijf.2_Silent_p.K67K	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	67	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(2)|central_nervous_system(1)	3						TCCCCACAAAAGGTGAGACTG	0.612													3	158					0	0	0	0	G	6255710	G	G	6255710	2	3	147	1	0	0	0	0	0	0	0	1	11817	86	3	5		5	PFKFB3	10	6255710	Silent	SNP	A	TCGA-CR-7377-01A-11D-2012-08		6255710	129279037	78	26987											
PCDH15	65217	broad.mit.edu	37	chr10	55600185	55600185	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaaaaggcatctccatgcCggcgagctccaatggactcc	10	6	12	13	2	1	0	0	0	1	0	4	3	3	2	4	4	2	2	4	4	3	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr10:55600185C>A	uc001jju.1	-	29	4273	c.3878G>T	c.(3877-3879)CGG>CTG	p.R1293L	PCDH15_uc010qhq.1_Missense_Mutation_p.R1298L|PCDH15_uc010qhr.1_Missense_Mutation_p.R1293L|PCDH15_uc010qhs.1_Missense_Mutation_p.R1305L|PCDH15_uc010qht.1_Missense_Mutation_p.R1300L|PCDH15_uc010qhu.1_Missense_Mutation_p.R1293L|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.R1293L|PCDH15_uc010qhw.1_Missense_Mutation_p.R1256L|PCDH15_uc010qhx.1_Missense_Mutation_p.R1222L|PCDH15_uc010qhy.1_Missense_Mutation_p.R1298L|PCDH15_uc010qhz.1_Missense_Mutation_p.R1293L|PCDH15_uc010qia.1_Missense_Mutation_p.R1271L|PCDH15_uc010qib.1_Missense_Mutation_p.R1271L	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1293	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATCTCCATGCCGGCGAGCTCC	0.448										HNSCC(58;0.16)			11	71					0.00829132	0.00961246	1	0	A	55600185	A	A	55600185	3	1	147	1	0	0	0	0	1	0	0	0	11565	652	23	3	3628	3	PCDH15	10	55600185	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	49344475	55600185	79934562	79	26988											
ARID5B	84159	broad.mit.edu	37	chr10	63829502	63829502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acatatttatgatgaattagGcggtaatcctgggagcacca	13	11	10	7	1	0	2	0	2	0	0	1	3	1	3	2	3	1	2	2	3	5	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr10:63829502G>A	uc001jlt.1	+	8	1171	c.1145G>A	c.(1144-1146)GGC>GAC	p.G382D	ARID5B_uc001jlu.1_Missense_Mutation_p.G139D	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	382	ARID.				liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GATGAATTAGGCGGTAATCCT	0.403													12	58					0	0	0	0	A	63829502	A	A	63829502	3	1	147	1	0	0	0	0	1	0	0	0	922	1203	42	4	1175	4	ARID5B	10	63829502	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	8229317	63829502	71705245	80	26989											
ZNF503	84858	broad.mit.edu	37	chr10	77160129	77160129	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagcgggctcttcttggcatCgagctgcggggtcagacgat	6	9	15	11	4	3	1	1	0	2	1	4	3	3	1	0	4	3	3	0	4	0	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr10:77160129C>G	uc001jxg.2	-	2	655	c.319G>C	c.(319-321)GAT>CAT	p.D107H	C10orf41_uc010qlf.1_5'Flank	NM_032772	NP_116161	Q96F45	ZN503_HUMAN	zinc finger protein 503	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1	all_cancers(46;0.105)|all_epithelial(25;0.00449)|Prostate(51;0.0112)|Ovarian(15;0.088)					TTCTTGGCATCGAGCTGCGGG	0.597													8	45					0	0	0	0	G	77160129	G	G	77160129	3	3	147	1	0	0	0	0	1	0	0	0	18018	884	31	3	1625	3	ZNF503	10	77160129	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	13330627	77160129	58374618	81	26990											
MUC5B	727897	broad.mit.edu	37	chr11	1156593	1156593	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagctggacaccaaatacGccaacaagacctgtgggctc	12	6	11	12	1	0	1	0	0	0	1	1	3	0	3	3	3	3	2	3	3	4	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:1156593G>A	uc009ycr.1	+	7	736	c.610G>A	c.(610-612)GCC>ACC	p.A204T		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	200	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACCAAATACGCCAACAAGAC	0.607													13	101					0	0	0	0	A	1156593	A	A	1156593	3	1	147	1	0	0	0	0	1	0	0	0	10032	1102	38	1		1	MUC5B	11	1156593	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08		1156593	133849923	82	26991											
CARS	833	broad.mit.edu	37	chr11	3038413	3038413	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctcacggctttccgggCtgccatatagaggttgcact	6	12	10	13	2	1	1	1	0	0	1	3	1	3	1	3	3	2	4	3	3	2	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:3038413C>A	uc001lxh.2	-	15	1665	c.1591G>T	c.(1591-1593)GCC>TCC	p.A531S	CARS_uc001lxe.2_Missense_Mutation_p.A521S|CARS_uc001lxf.2_Missense_Mutation_p.A614S|CARS_uc001lxg.2_Missense_Mutation_p.A531S|CARS_uc010qxo.1_Missense_Mutation_p.A614S|CARS_uc010qxp.1_Missense_Mutation_p.A544S	NM_001751	NP_001742	P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase isoform b	531					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|protein homodimerization activity|tRNA binding|tRNA binding		CARS/ALK(5)	soft_tissue(5)|ovary(2)	7		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	GCTTTCCGGGCTGCCATATAG	0.577			T	ALK	ALCL								8	71					5.18039e-06	6.28197e-06	1	0	A	3038413	A	A	3038413	3	1	147	1	0	0	0	0	1	0	0	0	2669	797	28	4	695	4	CARS	11	3038413	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	1881820	3038413	131968103	83	26992											
NUP98	4928	broad.mit.edu	37	chr11	3697423	3697423	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagccagttctcgcagatagGactgggtaaggctgcgcagt	9	8	14	10	2	1	1	0	0	1	1	2	2	1	2	1	3	2	5	1	3	2	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:3697423G>A	uc001lyh.2	-	33	5660	c.5369C>T	c.(5368-5370)TCC>TTC	p.S1790F	NUP98_uc001lyi.2_Missense_Mutation_p.S1716F|NUP98_uc001lyg.2_Missense_Mutation_p.S755F	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1807					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TCGCAGATAGGACTGGGTAAG	0.587			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								11	60					0	0	0	0	A	3697423	A	A	3697423	3	1	147	1	0	0	0	0	1	0	0	0	10827	1174	41	2	37	2	NUP98	11	3697423	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	659010	3697423	131309093	84	26993											
TAF10	6881	broad.mit.edu	37	chr11	6632171	6632173	+	In_Frame_Del	DEL	CTT	-	-																															gctcaggtgaagtagtgcggCttcttcacattgatgccata																										TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:6632171_6632173delCTT	uc001mej.1	-	5	662_664	c.637_639delAAG	c.(637-639)AAGdel	p.K213del		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	213					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AGTAGTGCGGCTTCTTCACATTG	0.458													---	---	---								-	6632173	-	-	6632171	7	5	147	1	0	1	0	1	0	0	0	0	15580	796	28	0	21	0	TAF10	11	6632171	In_Frame_Del	DEL	CTT	TCGA-CR-7377-01A-11D-2012-08	2934748	6632171	128374345	85	26994											
TPH1	7166	broad.mit.edu	37	chr11	18054883	18054883	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttggcacaatggtccaggtCagaaatcttctttggaaacc	11	11	10	9	0	3	1	1	0	2	1	4	2	4	2	2	4	1	2	2	4	3	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:18054883C>G	uc001mnp.2	-	3	366	c.340G>C	c.(340-342)GAC>CAC	p.D114H	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	114					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	TGGTCCAGGTCAGAAATCTTC	0.284													21	157					0	0	0	0	G	18054883	G	G	18054883	3	3	147	1	0	0	0	0	1	0	0	0	16468	826	29	2	1026	2	TPH1	11	18054883	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	11422712	18054883	116951633	86	26995											
HRASLS2	54979	broad.mit.edu	37	chr11	63326093	63326093	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctatggctttgttggtcaggGcagacaggacactggccgca	8	9	14	10	1	1	1	1	0	0	1	1	2	1	2	1	5	0	4	1	5	1	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:63326093G>A	uc001nxg.1	-	3	217	c.158C>T	c.(157-159)GCC>GTC	p.A53V		NM_017878	NP_060348	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	53					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity				0						GTTGGTCAGGGCAGACAGGAC	0.557													4	162					0	0	0	0	A	63326093	A	A	63326093	3	1	147	1	0	0	0	0	1	0	0	0	7389	1203	42	4	338	4	HRASLS2	11	63326093	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	45271210	63326093	71680423	87	26996											
IGHMBP2	3508	broad.mit.edu	37	chr11	68701351	68701351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcgggctgtttgagctggagGaggaggacgaacagtcgaaa	11	6	18	6	3	0	1	0	1	0	0	1	7	0	5	0	5	2	3	0	5	2	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:68701351G>A	uc001ook.1	+	10	1609	c.1507G>A	c.(1507-1509)GAG>AAG	p.E503K	IGHMBP2_uc001ool.1_Missense_Mutation_p.E127K|IGHMBP2_uc001oom.1_Missense_Mutation_p.E81K	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	503					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGAGCTGGAGGAGGAGGACGA	0.562													7	16					0	0	0	0	A	68701351	A	A	68701351	3	1	147	1	0	0	0	0	1	0	0	0	7630	1175	41	2	1545	2	IGHMBP2	11	68701351	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	5375258	68701351	66305165	88	26997											
MYO7A	4647	broad.mit.edu	37	chr11	76919561	76919561	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagctcggcccatcaaggaCggtaatgaggccgggtcctg	10	6	14	11	3	1	1	1	1	0	0	3	2	2	2	3	5	1	2	3	5	3	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:76919561C>T	uc001oyb.2	+	43	6215	c.5943C>T	c.(5941-5943)GAC>GAT	p.D1981D	MYO7A_uc001oyc.2_Silent_p.D1943D|MYO7A_uc001oye.2_RNA	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1981	FERM 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCATCAAGGACGGTAATGAGG	0.597													3	21					0	0	0	0	T	76919561	T	T	76919561	2	4	147	1	0	0	0	0	0	0	0	1	10135	550	19	1		1	MYO7A	11	76919561	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	8218210	76919561	58086955	89	26998											
SCN3B	55800	broad.mit.edu	37	chr11	123516409	123516410	+	Missense_Mutation	DNP	GG	AA	AA																															ttcatggggttgccctgcacGgcctccgtctccgagggcac																										TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr11:123516409_123516410GG>AA	uc001pza.1	-	3	511_512	c.104_105CC>TT	c.(103-105)GCC>GTT	p.A35V	SCN3B_uc001pzb.1_Missense_Mutation_p.A35V	NM_001040151	NP_001035241	Q9NY72	SCN3B_HUMAN	voltage-gated sodium channel beta-3 subunit	35	Ig-like C2-type.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		TGCCCTGCACGGCCTCCGTCTC	0.629													15	100					0	0	0	0	AA	123516410	AA	AA	123516409	3	1	147	1	0	0	0	0	1	0	0	0	13984	1103	39	1	558	1	SCN3B	11	123516409	Missense_Mutation	DNP	GG	TCGA-CR-7377-01A-11D-2012-08	46596848	123516409	11490107	90	26999											
GOLT1B	51026	broad.mit.edu	37	chr12	21668638	21668638	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagaaagcaacaatatggtAtaacaacaagtgaatttgaa	20	8	9	4	0	0	3	0	2	0	1	0	4	0	3	0	2	4	2	0	2	10	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:21668638A>G	uc001rez.2	+	5	573	c.414A>G	c.(412-414)GTA>GTG	p.V138V	GOLT1B_uc009zis.2_RNA|GOLT1B_uc009zit.2_RNA|GOLT1B_uc009ziu.2_RNA	NM_016072	NP_057156	Q9Y3E0	GOT1B_HUMAN	golgi transport 1 homolog B	138	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport|vesicle-mediated transport	endoplasmic reticulum|Golgi membrane|integral to membrane	signal transducer activity				0						ACAATATGGTATAACAACAAG	0.264													8	58					0	0	0	0	G	21668638	G	G	21668638	2	3	147	1	0	0	0	0	0	0	0	1	6608	436	16	5		5	GOLT1B	12	21668638	Silent	SNP	A	TCGA-CR-7377-01A-11D-2012-08		21668638	112183257	91	27000											
ASB8	140461	broad.mit.edu	37	chr12	48543152	48543152	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaaacatcttctccggctaTtctaaaagtaacaggtattc	13	12	6	10	1	3	0	0	0	3	0	5	0	3	0	1	2	2	4	1	2	6	7			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:48543152T>C	uc001rrh.2	-	4	1033	c.864A>G	c.(862-864)GAA>GAG	p.E288E	ASB8_uc010slr.1_Silent_p.E284E	NM_024095	NP_077000	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box-containing 8	288	SOCS box.				intracellular signal transduction	cytoplasm|nucleus				kidney(1)	1						TCTCCGGCTATTCTAAAAGTA	0.517													6	50					0	0	0	0	C	48543152	C	C	48543152	2	2	147	1	0	0	0	0	0	0	0	1	1031	1490	52	5		5	ASB8	12	48543152	Silent	SNP	T	TCGA-CR-7377-01A-11D-2012-08	26874514	48543152	85308743	92	27001											
TUBA1B	10376	broad.mit.edu	37	chr12	49521800	49521800	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatccacaccaacctcctCataatccttctcaagggcag	13	8	5	15	0	2	1	2	0	1	1	6	1	5	1	5	1	1	1	5	1	4	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:49521800C>A	uc001rtm.2	-	4	1518	c.1297G>T	c.(1297-1299)GAG>TAG	p.E433*	TUBA1B_uc001rto.2_Nonsense_Mutation_p.E398*|TUBA1B_uc001rtk.2_Nonsense_Mutation_p.E398*|TUBA1B_uc001rtl.2_Nonsense_Mutation_p.E398*|TUBA1B_uc001rtn.2_Nonsense_Mutation_p.E280*|uc010smg.1_5'UTR	NM_006082	NP_006073	P68363	TBA1B_HUMAN	tubulin, alpha, ubiquitous	433					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding				0						CCAACCTCCTCATAATCCTTC	0.517													29	168					1.88708e-17	2.38428e-17	1	0	A	49521800	A	A	49521800	4	1	147	1	0	0	0	0	0	1	0	0	16812	835	29	2	62	2	TUBA1B	12	49521800	Nonsense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	978648	49521800	84330095	93	27002											
ESYT1	23344	broad.mit.edu	37	chr12	56524381	56524381	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggtcagcttcccagacGtggaaaaggctgaatggctc	10	8	12	11	1	1	2	1	1	0	1	4	3	3	3	2	4	1	3	2	4	3	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:56524381G>A	uc001sjq.2	+	2	456	c.406G>A	c.(406-408)GTG>ATG	p.V136M	ESYT1_uc001sjr.2_Missense_Mutation_p.V136M	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	136						integral to membrane				ovary(4)|skin(1)	5						CTTCCCAGACGTGGAAAAGGC	0.507													12	76					0	0	0	0	A	56524381	A	A	56524381	3	1	147	1	0	0	0	0	1	0	0	0	5288	1145	40	1	412	1	ESYT1	12	56524381	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	7002581	56524381	77327514	94	27003											
TMEM19	55266	broad.mit.edu	37	chr12	72091109	72091109	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaatggagctgtacccacAgaactggccctgctgtacat	10	10	10	11	0	0	1	0	0	0	1	0	2	0	2	2	2	5	5	2	2	4	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:72091109A>G	uc001sws.2	+	4	1015	c.432A>G	c.(430-432)ACA>ACG	p.T144T	TMEM19_uc001swr.1_Silent_p.T130T|TMEM19_uc009zru.1_RNA	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	144						integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGTACCCACAGAACTGGCCC	0.468													27	128					0	0	0	0	G	72091109	G	G	72091109	2	3	147	1	0	0	0	0	0	0	0	1	16179	175	7	5		5	TMEM19	12	72091109	Silent	SNP	A	TCGA-CR-7377-01A-11D-2012-08	15566728	72091109	61760786	95	27004											
PWP1	11137	broad.mit.edu	37	chr12	108102726	108102726	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtacagatgacggctttgtAtataatttggatgcacgttc	11	14	10	6	2	0	2	0	1	0	1	1	3	0	3	0	2	2	5	0	2	4	7			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:108102726A>G	uc001tmo.1	+	12	1188	c.1101A>G	c.(1099-1101)GTA>GTG	p.V367V	PWP1_uc009zuu.1_Silent_p.V367V	NM_007062	NP_008993	Q13610	PWP1_HUMAN	periodic tryptophan protein 1	367					transcription, DNA-dependent	nucleus					0						ACGGCTTTGTATATAATTTGG	0.368													5	34					0	0	0	0	G	108102726	G	G	108102726	2	3	147	1	0	0	0	0	0	0	0	1	12908	436	16	5		5	PWP1	12	108102726	Silent	SNP	A	TCGA-CR-7377-01A-11D-2012-08	36011617	108102726	25749169	96	27005											
TMEM132B	114795	broad.mit.edu	37	chr12	126139185	126139185	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgataacatcaagtgggtcTgccaagatatggggctgggg	11	9	15	6	0	2	2	1	1	1	1	2	2	2	2	1	5	2	1	1	5	4	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr12:126139185T>A	uc001uhe.1	+	9	3174	c.3166T>A	c.(3166-3168)TGC>AGC	p.C1056S	TMEM132B_uc001uhf.1_Missense_Mutation_p.C568S	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	1056	Cytoplasmic (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CAAGTGGGTCTGCCAAGATAT	0.473													4	75					0	0	0	0	A	126139185	A	A	126139185	3	1	147	1	0	0	0	0	1	0	0	0	16112	1580	55	5	3200	5	TMEM132B	12	126139185	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08	18036459	126139185	7712710	97	27006											
SPERT	220082	broad.mit.edu	37	chr13	46287817	46287817	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgggccccctcgccactgctGcacaaagacagcgcgtccct	7	5	10	19	4	0	1	0	0	0	1	2	1	1	1	4	1	3	2	4	1	1	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr13:46287817G>A	uc001van.1	+	3	737	c.657G>A	c.(655-657)CTG>CTA	p.L219L	SPERT_uc001vao.2_Silent_p.L183L	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	219						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CGCCACTGCTGCACAAAGACA	0.657													4	47					0	0	0	0	A	46287817	A	A	46287817	2	1	147	1	0	0	0	0	0	0	0	1	15105	1306	46	4		4	SPERT	13	46287817	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08		46287817	68882061	98	27007											
LPAR6	10161	broad.mit.edu	37	chr13	48985944	48985944	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggttaaagtttttagcaccaTactagaacaagttacattta	15	14	6	6	0	0	1	0	0	0	1	0	1	0	1	1	1	4	4	1	1	9	9			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr13:48985944T>C	uc010acu.2	-	1	1710	c.616A>G	c.(616-618)ATG>GTG	p.M206V	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Missense_Mutation_p.M206V|LPAR6_uc001vcf.2_Missense_Mutation_p.M206V	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	206	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						TTTAGCACCATACTAGAACAA	0.254													5	38					0	0	0	0	C	48985944	C	C	48985944	3	2	147	1	0	0	0	0	1	0	0	0	8959	1406	49	5	422	5	LPAR6	13	48985944	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08	2698127	48985944	66183934	99	27008											
DIS3	22894	broad.mit.edu	37	chr13	73334727	73334727	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattagatgagtctaacatGattttcactttaactttatc	13	17	5	6	0	2	4	1	2	1	2	3	4	2	4	0	0	2	0	0	0	4	8			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr13:73334727G>T	uc001vix.3	-	20	3107	c.2733C>A	c.(2731-2733)ATC>ATA	p.I911I	DIS3_uc001viy.3_Silent_p.I881I|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	911					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		AGTCTAACATGATTTTCACTT	0.333										Multiple Myeloma(4;0.011)			12	57					6.40141e-05	7.67442e-05	1	0	T	73334727	T	T	73334727	2	4	147	1	0	0	0	0	0	0	0	1	4557	1280	45	2		2	DIS3	13	73334727	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08	24348783	73334727	41835151	100	27009											
CARS2	79587	broad.mit.edu	37	chr13	111299462	111299462	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcttacctctcccacagcatCgcttccctgacggagccgca	7	9	7	18	3	2	1	0	1	2	0	5	2	3	2	4	1	3	3	4	1	1	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr13:111299462C>T	uc001vrd.2	-	11	1219	c.1179G>A	c.(1177-1179)GCG>GCA	p.A393A	CARS2_uc010tjm.1_RNA	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	393					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	CCCACAGCATCGCTTCCCTGA	0.672													3	14					0	0	0	0	T	111299462	T	T	111299462	2	4	147	1	0	0	0	0	0	0	0	1	2670	871	31	1		1	CARS2	13	111299462	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	37964735	111299462	3870416	101	27010											
C13orf16	121793	broad.mit.edu	37	chr13	111973249	111973249	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgcagcaatggaatacgtGctggaagtgaagaactctcc	12	8	12	9	1	1	2	0	1	1	1	2	4	1	4	1	2	5	4	1	2	6	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr13:111973249G>T	uc001vsa.2	+	2	141	c.12G>T	c.(10-12)GTG>GTT	p.V4V		NM_152324	NP_689537	Q8N6K0	CM016_HUMAN	hypothetical protein LOC121793	4	Extracellular (Potential).					integral to membrane					0	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		all cancers(43;0.113)|GBM - Glioblastoma multiforme(44;0.174)|BRCA - Breast invasive adenocarcinoma(86;0.188)			TGGAATACGTGCTGGAAGTGA	0.642													5	108					0.000602214	0.000709873	1	0	T	111973249	T	T	111973249	2	4	147	1	0	0	0	0	0	0	0	1	1725	1306	46	4		4	C13orf16	13	111973249	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08	673787	111973249	3196629	102	27011											
OSGEP	55644	broad.mit.edu	37	chr14	20917164	20917164	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtatcctggacttgggtcGttagaaatctagcagaagaa	12	12	11	6	1	1	3	0	0	1	3	3	4	2	4	1	2	1	3	1	2	6	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr14:20917164G>A	uc001vxf.2	-	5	872	c.516C>T	c.(514-516)AAC>AAT	p.N172N		NM_017807	NP_060277	Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase	172					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		GACTTGGGTCGTTAGAAATCT	0.453													21	198					0	0	0	0	A	20917164	A	A	20917164	2	1	147	1	0	0	0	0	0	0	0	1	11341	1136	40	1		1	OSGEP	14	20917164	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08		20917164	86432376	103	27012											
GMPR2	51292	broad.mit.edu	37	chr14	24702464	24702464	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgaggctaagcgccatgcCtcatattgacaacgatgtga	11	8	10	12	3	1	2	1	2	0	0	1	4	1	2	3	1	3	1	3	1	3	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr14:24702464C>T	uc001wnr.2	+	2	387	c.5C>T	c.(4-6)CCT>CTT	p.P2L	NEDD8_uc001wnn.2_5'Flank|NEDD8_uc001wno.2_5'Flank|NEDD8_uc001wnp.2_5'Flank|GMPR2_uc001wnq.1_Missense_Mutation_p.P2L|GMPR2_uc001wnv.2_5'UTR|GMPR2_uc001wns.2_Missense_Mutation_p.P2L|GMPR2_uc001wnt.2_Missense_Mutation_p.P2L|GMPR2_uc001wnu.2_5'UTR|GMPR2_uc001wnw.2_Missense_Mutation_p.P2L|GMPR2_uc010all.2_Missense_Mutation_p.P2L|GMPR2_uc001wnx.2_Missense_Mutation_p.P20L|GMPR2_uc010tod.1_Missense_Mutation_p.P2L|GMPR2_uc010alk.1_Missense_Mutation_p.P2L|GMPR2_uc010toe.1_Missense_Mutation_p.P2L	NM_001002001	NP_001002001	Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2 isoform 2	2					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			ovary(3)	3				GBM - Glioblastoma multiforme(265;0.0181)		AGCGCCATGCCTCATATTGAC	0.517													79	341					0	0	0	0	T	24702464	T	T	24702464	3	4	147	1	0	0	0	0	1	0	0	0	6534	681	24	4	61	4	GMPR2	14	24702464	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	3785300	24702464	82647076	104	27013											
COCH	1690	broad.mit.edu	37	chr14	31348049	31348049	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caactcagggggacctgtacGagtctatagcctacctggtc	9	9	11	12	1	2	0	1	0	1	0	3	2	2	1	3	3	4	1	3	3	5	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr14:31348049G>A	uc001wqr.2	+	5	352	c.272G>A	c.(271-273)CGA>CAA	p.R91Q	COCH_uc001wqp.2_Missense_Mutation_p.R91Q|COCH_uc001wqq.3_Missense_Mutation_p.R91Q|uc001wqs.2_Intron|COCH_uc001wqt.1_5'Flank	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	91	LCCL.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		GGACCTGTACGAGTCTATAGC	0.458													17	81					0	0	0	0	A	31348049	A	A	31348049	3	1	147	1	0	0	0	0	1	0	0	0	3671	1058	37	1	286	1	COCH	14	31348049	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	6645585	31348049	76001491	105	27014											
NRXN3	9369	broad.mit.edu	37	chr14	79933641	79933641	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaatgacaggcccagcacgCggtctgaccgccttgccgtg	7	6	12	16	4	1	2	0	2	1	0	1	2	1	2	5	2	2	1	5	2	1	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr14:79933641C>T	uc001xun.2	+	13	2712	c.2221C>T	c.(2221-2223)CGG>TGG	p.R741W	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.R109W|NRXN3_uc010asw.2_Missense_Mutation_p.R109W|NRXN3_uc001xur.3_Missense_Mutation_p.R109W	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1114	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCCCAGCACGCGGTCTGACCG	0.577													19	94					0	0	0	0	T	79933641	T	T	79933641	3	4	147	1	0	0	0	0	1	0	0	0	10721	759	27	1	2514	1	NRXN3	14	79933641	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	48585592	79933641	27415899	106	27015											
KIAA1409	57578	broad.mit.edu	37	chr14	94089060	94089060	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggatggagctgaggaatcCgaatttaagattcagattgt	13	11	13	4	1	1	3	1	1	0	2	2	8	2	6	1	3	1	1	1	3	3	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr14:94089060C>T	uc001ybv.1	+	28	5099	c.5016C>T	c.(5014-5016)TCC>TCT	p.S1672S	KIAA1409_uc001ybs.1_Silent_p.S1650S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1827						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CTGAGGAATCCGAATTTAAGA	0.473													7	46					0	0	0	0	T	94089060	T	T	94089060	2	4	147	1	0	0	0	0	0	0	0	1	8269	639	23	1		1	KIAA1409	14	94089060	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	14155419	94089060	13260480	107	27016											
SORD	6652	broad.mit.edu	37	chr15	45353314	45353314	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccgagaaaatgatgaattCtgcaagatgggccgatacaa	15	7	10	9	2	1	4	0	2	1	2	1	6	1	4	3	1	2	1	3	1	6	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr15:45353314C>G	uc001zul.3	+	4	456	c.315C>G	c.(313-315)TTC>TTG	p.F105L	SORD_uc010uel.1_Intron|SORD_uc001zum.3_Missense_Mutation_p.F105L|SORD_uc010bdz.2_Missense_Mutation_p.F26L	NM_003104	NP_003095	Q00796	DHSO_HUMAN	sorbitol dehydrogenase	105					fructose biosynthetic process|glucose metabolic process|L-xylitol catabolic process|sorbitol catabolic process|sperm motility	cilium|extracellular space|flagellum|membrane fraction|mitochondrial membrane|soluble fraction	L-iditol 2-dehydrogenase activity|NAD binding|sugar binding|zinc ion binding				0		all_cancers(109;3.43e-12)|all_epithelial(112;2.33e-10)|Lung NSC(122;6.01e-07)|all_lung(180;4.38e-06)|Melanoma(134;0.0122)		all cancers(107;1.6e-18)|GBM - Glioblastoma multiforme(94;4.95e-07)|COAD - Colon adenocarcinoma(120;0.0704)|Colorectal(133;0.0706)	NADH(DB00157)	ATGATGAATTCTGCAAGATGG	0.542													7	57					0	0	0	0	G	45353314	G	G	45353314	3	3	147	1	0	0	0	0	1	0	0	0	14997	912	32	2	329	2	SORD	15	45353314	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08		45353314	57178078	108	27017											
RNF111	54778	broad.mit.edu	37	chr15	59373425	59373425	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccagcacagagactgcatCctcatgaagtgatgcagagg	12	7	11	11	0	1	4	1	2	0	2	3	5	3	4	2	1	3	3	2	1	1	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr15:59373425C>T	uc002afv.2	+	8	2518	c.2239C>T	c.(2239-2241)CCT>TCT	p.P747S	RNF111_uc002afs.2_Missense_Mutation_p.P747S|RNF111_uc002aft.2_Missense_Mutation_p.P747S|RNF111_uc002afu.2_Missense_Mutation_p.P746S|RNF111_uc002afw.2_Missense_Mutation_p.P747S|RNF111_uc002afx.2_Missense_Mutation_p.P273S	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	747	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		GAGACTGCATCCTCATGAAGT	0.463													11	83					0	0	0	0	T	59373425	T	T	59373425	3	4	147	1	0	0	0	0	1	0	0	0	13490	855	30	2	2265	2	RNF111	15	59373425	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	14020111	59373425	43157967	109	27018											
THSD4	79875	broad.mit.edu	37	chr15	72030124	72030124	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggagccaggaggagggaGaacagaaagggaggaacgag	16	0	20	5	1	0	2	0	0	0	2	0	9	0	7	1	6	3	1	1	6	3	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr15:72030124G>A	uc002atb.1	+	10	1763	c.1684G>A	c.(1684-1686)GAA>AAA	p.E562K	THSD4_uc010ukg.1_Missense_Mutation_p.E202K|THSD4_uc002ate.2_Missense_Mutation_p.E202K	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	562						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						GGAGGAGGGAGAACAGAAAGG	0.562													11	62					0	0	0	0	A	72030124	A	A	72030124	3	1	147	1	0	0	0	0	1	0	0	0	15944	943	33	2	1722	2	THSD4	15	72030124	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	12656699	72030124	30501268	110	27019											
SNRNP25	79622	broad.mit.edu	37	chr16	104045	104045	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggacccgctgctctgcgAtctgccgatccaggtgtgtg	5	9	14	13	3	2	0	0	0	2	0	3	3	3	1	3	2	3	3	3	2	0	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:104045A>G	uc002cfj.3	+	1	217	c.56A>G	c.(55-57)GAT>GGT	p.D19G	POLR3K_uc002cfi.1_5'Flank|SNRNP25_uc002cfk.3_5'Flank	NM_024571	NP_078847	Q9BV90	SNR25_HUMAN	U11/U12 snRNP 25K protein	19					mRNA processing	U12-type spliceosomal complex					0						CTGCTCTGCGATCTGCCGATC	0.701													5	22					0	0	0	0	G	104045	G	G	104045	3	3	147	1	0	0	0	0	1	0	0	0	14917	333	12	5	58	5	SNRNP25	16	104045	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08		104045	90250708	111	27020											
IGFALS	3483	broad.mit.edu	37	chr16	1842153	1842153	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggaaggctgccggggggAcggacgagaggttgttgccg	6	7	20	8	4	1	1	0	0	1	1	1	5	1	4	2	7	2	3	2	7	1	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:1842153A>G	uc002cmy.2	-	2	347	c.266T>C	c.(265-267)GTC>GCC	p.V89A	IGFALS_uc010uvn.1_Missense_Mutation_p.V127A|IGFALS_uc010uvo.1_5'UTR	NM_004970	NP_004961	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid	89	LRR 1.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding				0						TGCCGGGGGGACGGACGAGAG	0.687													3	40					0	0	0	0	G	1842153	G	G	1842153	3	3	147	1	0	0	0	0	1	0	0	0	7616	275	10	5	1555	5	IGFALS	16	1842153	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	1738108	1842153	88512600	112	27021											
DNAH3	55567	broad.mit.edu	37	chr16	20994156	20994156	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcgtacagcaattgatcagCgaagggaacatccgcaggcg	13	6	12	10	4	1	1	1	1	0	0	3	3	2	2	1	2	4	3	1	2	4	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:20994156C>T	uc010vbe.1	-	49	7746	c.7746G>A	c.(7744-7746)TCG>TCA	p.S2582S	DNAH3_uc010vbd.1_Silent_p.S17S	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2582	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AATTGATCAGCGAAGGGAACA	0.483													13	78					0	0	0	0	T	20994156	T	T	20994156	2	4	147	1	0	0	0	0	0	0	0	1	4625	755	27	1		1	DNAH3	16	20994156	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	19152003	20994156	69360597	113	27022											
GDPD3	79153	broad.mit.edu	37	chr16	30124099	30124100	+	Missense_Mutation	DNP	GC	AA	AA																															tcgagctccaggaggtccgaGcgctgggccatggagctgtg																										TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:30124099_30124100GC>AA	uc002dwp.2	-	3	276_277	c.197_198GC>TT	c.(196-198)CGC>CTT	p.R66L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Missense_Mutation_p.R4L|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	66	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						GGAGGTCCGAGCGCTGGGCCAT	0.653											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	84					0	0	0	0	AA	30124100	AA	AA	30124099	3	1	147	1	0	0	0	0	1	0	0	0	6362	958	34	4	790	4	GDPD3	16	30124099	Missense_Mutation	DNP	GC	TCGA-CR-7377-01A-11D-2012-08	9129943	30124099	60230654	114	27023											
ITGAX	3687	broad.mit.edu	37	chr16	31383062	31383062	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgagccgagtccgagtccTcgggctgaaggcacactgtg	7	8	14	12	3	1	2	0	2	1	0	4	4	3	2	3	2	1	2	3	2	1	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:31383062T>C	uc002ebu.1	+	17	2184	c.2117T>C	c.(2116-2118)CTC>CCC	p.L706P	ITGAX_uc002ebt.2_Missense_Mutation_p.L706P	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	706	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTCCGAGTCCTCGGGCTGAAG	0.632													7	85					0	0	0	0	C	31383062	C	C	31383062	3	2	147	1	0	0	0	0	1	0	0	0	7928	1551	54	5	2183	5	ITGAX	16	31383062	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08	1258963	31383062	58971691	115	27024											
ABCC11	85320	broad.mit.edu	37	chr16	48226462	48226462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcttgttgtgcagggccgtgGatgccttcctcgtgaccttg	3	13	14	11	2	0	1	0	1	0	0	2	2	1	2	4	2	2	3	4	2	0	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:48226462G>A	uc002eff.1	-	19	3025	c.2675C>T	c.(2674-2676)TCC>TTC	p.S892F	ABCC11_uc002efg.1_Missense_Mutation_p.S892F|ABCC11_uc002efh.1_Missense_Mutation_p.S892F|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	892	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CAGGGCCGTGGATGCCTTCCT	0.562									Cerumen_Type				10	79					0	0	0	0	A	48226462	A	A	48226462	3	1	147	1	0	0	0	0	1	0	0	0	51	1174	41	2	1517	2	ABCC11	16	48226462	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	16843400	48226462	42128291	116	27025											
CDYL2	124359	broad.mit.edu	37	chr16	80638322	80638322	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtcctgcaggtagctgaaaAgggagtcaaggcctttggag	10	9	15	7	0	1	1	1	1	0	0	2	3	2	3	2	4	2	3	2	4	4	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:80638322A>G	uc002ffs.2	-	7	1589	c.1484T>C	c.(1483-1485)CTT>CCT	p.L495P		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	495						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						GTAGCTGAAAAGGGAGTCAAG	0.552													3	129					0	0	0	0	G	80638322	G	G	80638322	3	3	147	1	0	0	0	0	1	0	0	0	3201	72	3	5	40	5	CDYL2	16	80638322	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	32411860	80638322	9716431	117	27026											
ZNF276	92822	broad.mit.edu	37	chr16	89789017	89789017	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagaagcctgcgcagcatctCcgagagggcgcctggagcga	9	4	16	12	4	1	2	0	0	1	2	2	6	1	3	3	2	4	2	3	2	1	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr16:89789017C>T	uc002fos.3	+	2	381	c.284C>T	c.(283-285)TCC>TTC	p.S95F	C16orf7_uc002fol.1_5'Flank|C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Missense_Mutation_p.S20F|ZNF276_uc002foq.3_Missense_Mutation_p.S20F|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	95	ZAD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CGCAGCATCTCCGAGAGGGCG	0.667													10	94					0	0	0	0	T	89789017	T	T	89789017	3	4	147	1	0	0	0	0	1	0	0	0	17878	855	30	2	290	2	ZNF276	16	89789017	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	9150695	89789017	565736	118	27027											
CAMTA2	23125	broad.mit.edu	37	chr17	4873662	4873662	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttgagctggggaaatggTccacattctccaggtagctg	8	10	15	8	0	1	1	0	1	1	0	3	2	2	2	2	5	2	4	2	5	2	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:4873662T>C	uc002gah.1	-	17	3086	c.2978A>G	c.(2977-2979)GAC>GGC	p.D993G	SPAG7_uc002gae.2_5'Flank|SPAG7_uc002gaf.2_5'Flank|CAMTA2_uc010cku.1_Missense_Mutation_p.D1016G|CAMTA2_uc002gag.1_Missense_Mutation_p.D992G|CAMTA2_uc002gai.1_Missense_Mutation_p.D995G|CAMTA2_uc010ckv.1_Missense_Mutation_p.D640G	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	993					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GGGGAAATGGTCCACATTCTC	0.602													3	108					0	0	0	0	C	4873662	C	C	4873662	3	2	147	1	0	0	0	0	1	0	0	0	2626	1667	58	5	708	5	CAMTA2	17	4873662	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08		4873662	76321548	119	27028											
TP53	7157	broad.mit.edu	37	chr17	7577022	7577022	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtcctgcttgcttacctcGcttagtgctccctgggggca	3	14	11	13	1	0	0	0	0	0	0	3	0	2	0	3	2	4	5	3	2	2	4	rs121913344		TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:7577022G>A	uc002gim.2	-	8	1110	c.916C>T	c.(916-918)CGA>TGA	p.R306*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.R306*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R174*|TP53_uc010cng.1_Nonsense_Mutation_p.R174*|TP53_uc002gii.1_Nonsense_Mutation_p.R174*|TP53_uc010cnh.1_Nonsense_Mutation_p.R306*|TP53_uc010cni.1_Nonsense_Mutation_p.R306*|TP53_uc002gij.2_Nonsense_Mutation_p.R306*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	306	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		R -> Q (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(99)|p.0?(7)|p.?(3)|p.R306R(2)|p.R306fs*39(2)|p.K305fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTACCTCGCTTAGTGCTC	0.562	R306*(MFE296_ENDOMETRIUM)|R306*(HCC1937_BREAST)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	75					0	0	0	0	A	7577022	A	A	7577022	4	1	147	1	0	0	0	0	0	1	0	0	16448	1095	38	1	370	1	TP53	17	7577022	Nonsense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	2703360	7577022	73618188	120	27029											
MYCBPAP	84073	broad.mit.edu	37	chr17	48597049	48597049	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactggaatacttgggagatGagatgacaggtctggtcatg	11	10	15	5	0	2	3	1	2	1	2	2	7	2	4	0	4	1	0	0	4	2	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:48597049G>A	uc010wmr.1	+	7	1108	c.946G>A	c.(946-948)GAG>AAG	p.E316K	MYCBPAP_uc002iqx.2_Missense_Mutation_p.E316K|MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	279					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CTTGGGAGATGAGATGACAGG	0.547													7	44					0	0	0	0	A	48597049	A	A	48597049	3	1	147	1	0	0	0	0	1	0	0	0	10072	1291	45	2	972	2	MYCBPAP	17	48597049	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	41020027	48597049	32598161	121	27030											
CA10	56934	broad.mit.edu	37	chr17	49825158	49825158	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agggatacgtgtcttccagtGttgtacatggtcccactgac	8	12	11	10	1	1	1	0	1	1	0	3	2	3	2	2	2	2	2	2	2	2	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:49825158G>A	uc002itw.3	-	4	1286	c.300C>T	c.(298-300)AAC>AAT	p.N100N	CA10_uc002itu.3_Silent_p.N29N|CA10_uc002itv.3_Silent_p.N106N|CA10_uc002itx.3_Silent_p.N100N|CA10_uc002ity.3_Silent_p.N100N|CA10_uc002itz.2_Silent_p.N100N	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	100					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GTCTTCCAGTGTTGTACATGG	0.542													11	81					0	0	0	0	A	49825158	A	A	49825158	2	1	147	1	0	0	0	0	0	0	0	1	2523	1368	48	4		4	CA10	17	49825158	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08	1228109	49825158	31370052	122	27031											
INTS2	57508	broad.mit.edu	37	chr17	59972740	59972740	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaaggagcttggcttaattAcaatctaaaattaccaaaag	17	11	6	7	0	2	0	1	0	1	0	2	1	2	1	1	2	3	2	1	2	9	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:59972740A>G	uc002izn.2	-	12	1599	c.1523T>C	c.(1522-1524)GTA>GCA	p.V508A	INTS2_uc002izm.2_Missense_Mutation_p.V500A	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	508					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						TGGCTTAATTACAATCTAAAA	0.294													4	15					0	0	0	0	G	59972740	G	G	59972740	3	3	147	1	0	0	0	0	1	0	0	0	7817	391	14	5	2147	5	INTS2	17	59972740	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	10147582	59972740	21222470	123	27032											
MRC2	9902	broad.mit.edu	37	chr17	60749025	60749025	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagacaggtgggccaatgTgaaggtggagtgcgagccga	10	6	18	7	2	0	2	0	1	0	1	0	5	0	3	2	4	3	1	2	4	2	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr17:60749025T>A	uc002jad.2	+	7	1535	c.1133T>A	c.(1132-1134)GTG>GAG	p.V378E	MRC2_uc002jac.2_Missense_Mutation_p.V378E	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	378	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TGGGCCAATGTGAAGGTGGAG	0.632													6	42					0	0	0	0	A	60749025	A	A	60749025	3	1	147	1	0	0	0	0	1	0	0	0	9811	1696	59	5	1159	5	MRC2	17	60749025	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08	776285	60749025	20446185	124	27033											
C19orf21	126353	broad.mit.edu	37	chr19	758519	758519	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaggcccaagtcccccatGtctggggctgggaggtggct	6	7	16	12	0	1	0	0	0	1	0	2	1	2	1	3	6	1	3	3	6	1	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:758519G>T	uc002lpo.2	+	2	1656	c.1573G>T	c.(1573-1575)GTC>TTC	p.V525F		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	525										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCCCCCATGTCTGGGGCTG	0.672													17	58					1.02788e-11	1.27578e-11	1	0	T	758519	T	T	758519	3	4	147	1	0	0	0	0	1	0	0	0	1922	1377	48	4	1575	4	C19orf21	19	758519	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08		758519	58370464	125	27034											
DENND1C	79958	broad.mit.edu	37	chr19	6476960	6476960	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcgtcagtcacggccaccaCcagctccgttaggttcctct	6	10	8	17	3	3	0	2	0	1	0	6	0	5	0	5	2	1	3	5	2	1	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:6476960C>T	uc002mfe.2	-	10	678	c.586G>A	c.(586-588)GTG>ATG	p.V196M	DENND1C_uc002mfb.2_5'Flank|DENND1C_uc002mfc.2_5'Flank|DENND1C_uc002mfd.2_Translation_Start_Site|DENND1C_uc010xje.1_Missense_Mutation_p.V152M	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	196	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						ACGGCCACCACCAGCTCCGTT	0.642													12	40					0	0	0	0	T	6476960	T	T	6476960	3	4	147	1	0	0	0	0	1	0	0	0	4450	507	18	4	1875	4	DENND1C	19	6476960	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	5718441	6476960	52652023	126	27035											
ZNF177	7730	broad.mit.edu	37	chr19	9489013	9489013	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcagggtggctgacaacctGgtcacaggtacacaagaaat	13	7	12	9	0	1	2	1	1	0	1	1	2	1	2	1	4	3	3	1	4	4	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:9489013G>C	uc002mli.2	+	8	689	c.26G>C	c.(25-27)TGG>TCG	p.W9S	ZNF177_uc002mlj.2_5'UTR|ZNF177_uc002mlk.2_Missense_Mutation_p.W9S	NM_003451	NP_003442	Q13360	ZN177_HUMAN	zinc finger protein 177	9					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTGACAACCTGGTCACAGGTA	0.507													4	52					0	0	0	0	C	9489013	C	C	9489013	3	2	147	1	0	0	0	0	1	0	0	0	17813	1357	47	4	28	4	ZNF177	19	9489013	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	3012053	9489013	49639970	127	27036											
FARSA	2193	broad.mit.edu	37	chr19	13035607	13035607	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgatggagaagtacttgacCggagtgaagggcttctaggg	10	9	16	6	2	1	3	0	2	1	1	2	6	1	4	1	4	1	2	1	4	4	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:13035607C>T	uc002mvs.2	-	10	1089	c.1041G>A	c.(1039-1041)CCG>CCA	p.P347P	FARSA_uc002mvt.2_RNA|FARSA_uc010xmv.1_Silent_p.P316P|FARSA_uc010dyy.1_Silent_p.P268P	NM_004461	NP_004452	Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	347					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)	AGTACTTGACCGGAGTGAAGG	0.632													12	161					0	0	0	0	T	13035607	T	T	13035607	2	4	147	1	0	0	0	0	0	0	0	1	5711	639	23	1		1	FARSA	19	13035607	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	3546594	13035607	46093376	128	27037											
ASF1B	55723	broad.mit.edu	37	chr19	14247232	14247232	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtggaaagggctcgggttctCcaggaccgccacgttcagca	8	7	14	12	3	2	0	1	0	1	0	4	2	2	2	3	4	1	4	3	4	1	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:14247232C>T	uc002mye.2	-	1	209	c.37G>A	c.(37-39)GAG>AAG	p.E13K	uc002myf.2_5'Flank	NM_018154	NP_060624	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B	13	Interaction with CHAF1B.|Interaction with histone H3 (By similarity).				cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus					0						CTCGGGTTCTCCAGGACCGCC	0.716													13	49					0	0	0	0	T	14247232	T	T	14247232	3	4	147	1	0	0	0	0	1	0	0	0	1040	864	30	2	587	2	ASF1B	19	14247232	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	1211625	14247232	44881751	129	27038											
ZNF676	163223	broad.mit.edu	37	chr19	22363559	22363559	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgttcagtaaggcttgaggaCcagctgaaggctttgccaca	10	10	12	9	0	1	2	1	2	0	0	1	3	1	3	2	3	2	5	2	3	2	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:22363559C>G	uc002nqs.1	-	3	1278	c.960G>C	c.(958-960)TGG>TGC	p.W320C		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	320	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GGCTTGAGGACCAGCTGAAGG	0.433													11	105					0	0	0	0	G	22363559	G	G	22363559	3	3	147	1	0	0	0	0	1	0	0	0	18150	508	18	4	810	4	ZNF676	19	22363559	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	8116327	22363559	36765424	130	27039											
ZNF99	7652	broad.mit.edu	37	chr19	22939799	22939799	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	attatcttatgtttcctaagGgctgagaaattgctaaaagc	13	14	8	6	0	1	1	0	1	1	1	2	2	2	1	1	1	2	3	1	1	6	6			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:22939799G>A	uc010xrh.1	-	6	2532	c.2532C>T	c.(2530-2532)GCC>GCT	p.A844A		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GTTTCCTAAGGGCTGAGAAAT	0.348													13	86					0	0	0	0	A	22939799	A	A	22939799	2	1	147	1	0	0	0	0	0	0	0	1	18271	1219	43	4		4	ZNF99	19	22939799	Silent	SNP	G	TCGA-CR-7377-01A-11D-2012-08	576240	22939799	36189184	131	27040											
WTIP	126374	broad.mit.edu	37	chr19	34984493	34984493	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcccttcaccgtggacgtgGagaacaacatctactgcgtg	9	10	10	12	3	2	1	1	0	1	1	3	3	3	2	2	2	4	0	2	2	3	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:34984493G>T	uc002nvm.2	+	5	997	c.997G>T	c.(997-999)GAG>TAG	p.E333*		NM_001080436	NP_001073905			Wilms tumor 1 interacting protein												0	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			CGTGGACGTGGAGAACAACAT	0.617													11	99					0.00829132	0.00961246	1	0	T	34984493	T	T	34984493	4	4	147	1	0	0	0	0	0	1	0	0	17478	1175	41	2	1015	2	WTIP	19	34984493	Nonsense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	12044694	34984493	24144490	132	27041											
MLL4	9757	broad.mit.edu	37	chr19	36212436	36212436	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggctccagctctgagcaaCgggccacagacacaggctca	10	4	13	14	1	2	2	1	1	1	1	3	2	3	2	2	4	3	4	2	4	1	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:36212436C>T	uc010eei.2	+	3	2187	c.2187C>T	c.(2185-2187)AAC>AAT	p.N729N		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	729	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCTGAGCAACGGGCCACAGA	0.662													6	60					0	0	0	0	T	36212436	T	T	36212436	2	4	147	1	0	0	0	0	0	0	0	1	9676	535	19	1		1	MLL4	19	36212436	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	1227943	36212436	22916547	133	27042											
HNRNPL	3191	broad.mit.edu	37	chr19	39336375	39336375	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acagatagtgtaaagaacatCctgcaaaagcaaacacaggc	19	5	8	9	0	0	2	0	0	0	2	1	2	1	2	1	1	4	3	1	1	7	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:39336375C>A	uc010xul.1	-	4	636	c.625G>T	c.(625-627)GAT>TAT	p.D209Y	HNRNPL_uc010xum.1_Missense_Mutation_p.D76Y|HNRNPL_uc010xun.1_5'Flank	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	209	RRM 2.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			TAAAGAACATCCTGCAAAAGC	0.478													5	59					0.000602214	0.000709873	1	0	A	39336375	A	A	39336375	3	1	147	1	0	0	0	0	1	0	0	0	7309	869	30	2	1184	2	HNRNPL	19	39336375	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	3123939	39336375	19792608	134	27043											
STRN4	29888	broad.mit.edu	37	chr19	47226075	47226075	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagcccccttaccgctgctgCcccgggactccagcgtgagg	5	6	12	18	3	0	1	0	1	0	0	1	2	1	2	6	2	5	2	6	2	1	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr19:47226075C>T	uc002pfl.2	-	14	1931	c.1898G>A	c.(1897-1899)GGC>GAC	p.G633D	STRN4_uc002pfm.2_Missense_Mutation_p.G640D|STRN4_uc010xyf.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	633						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		ACCGCTGCTGCCCCGGGACTC	0.627													23	134					0	0	0	0	T	47226075	T	T	47226075	3	4	147	1	0	0	0	0	1	0	0	0	15397	739	26	4	379	4	STRN4	19	47226075	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	7889700	47226075	11902908	135	27044											
ENTPD6	955	broad.mit.edu	37	chr20	25188018	25188018	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtacacgtcttccagttcAcccggccccccagaggtacc	8	7	9	17	2	2	1	1	0	1	1	3	2	3	1	6	2	2	3	6	2	2	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr20:25188018A>C	uc002wuj.2	+	3	541	c.361A>C	c.(361-363)ACC>CCC	p.T121P	ENTPD6_uc010zsy.1_Missense_Mutation_p.T121P|ENTPD6_uc010gdj.1_Missense_Mutation_p.T93P|ENTPD6_uc010zsz.1_Intron|ENTPD6_uc002wum.2_Missense_Mutation_p.T104P|ENTPD6_uc010zta.1_Missense_Mutation_p.T121P|ENTPD6_uc002wun.2_Missense_Mutation_p.T121P|ENTPD6_uc002wuk.2_Missense_Mutation_p.T120P|ENTPD6_uc002wul.2_Missense_Mutation_p.T120P|ENTPD6_uc010ztb.1_Missense_Mutation_p.T93P|ENTPD6_uc010ztc.1_Missense_Mutation_p.T93P|ENTPD6_uc002wuo.2_Intron|ENTPD6_uc010ztd.1_5'Flank	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	121	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						CTTCCAGTTCACCCGGCCCCC	0.587													9	49					0	0	0	0	C	25188018	C	C	25188018	3	2	147	1	0	0	0	0	1	0	0	0	5167	159	6	5	374	5	ENTPD6	20	25188018	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08		25188018	37837502	136	27045											
NINL	22981	broad.mit.edu	37	chr20	25456758	25456758	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagaagtttggtttccatgtCatccttctctctctccagcg	6	16	7	12	1	3	1	1	0	2	1	8	1	6	1	3	1	1	2	3	1	2	4			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr20:25456758C>T	uc002wux.1	-	17	3243	c.3169G>A	c.(3169-3171)GAC>AAC	p.D1057N	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1057	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GTTTCCATGTCATCCTTCTCT	0.532													33	108					0	0	0	0	T	25456758	T	T	25456758	3	4	147	1	0	0	0	0	1	0	0	0	10474	826	29	2	1011	2	NINL	20	25456758	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	268740	25456758	37568762	137	27046											
ZNF334	55713	broad.mit.edu	37	chr20	45131154	45131154	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgaggcttgtcttcacaCgaaaagttttcctacaatca	12	12	8	9	1	3	1	2	1	1	0	4	3	4	1	1	1	1	2	1	1	4	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr20:45131154C>T	uc002xsc.2	-	5	1008	c.824G>A	c.(823-825)CGT>CAT	p.R275H	ZNF334_uc002xsa.2_Missense_Mutation_p.R298H|ZNF334_uc002xsb.2_Missense_Mutation_p.R237H|ZNF334_uc002xsd.2_Missense_Mutation_p.R237H|ZNF334_uc010ghl.2_Missense_Mutation_p.R274H	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	275	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				TGTCTTCACACGAAAAGTTTT	0.413													15	113					0	0	0	0	T	45131154	T	T	45131154	3	4	147	1	0	0	0	0	1	0	0	0	17918	536	19	1	1222	1	ZNF334	20	45131154	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	19674396	45131154	17894366	138	27047											
ZNF831	128611	broad.mit.edu	37	chr20	57767313	57767313	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcatcgcccagctcatctcCcacaaccaggcggtggtgga	8	6	11	16	3	2	0	1	0	1	0	4	1	2	1	3	4	2	2	3	4	1	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr20:57767313C>T	uc002yan.2	+	1	1239	c.1239C>T	c.(1237-1239)TCC>TCT	p.S413S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	413	Potential.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AGCTCATCTCCCACAACCAGG	0.532													5	17					0	0	0	0	T	57767313	T	T	57767313	2	4	147	1	0	0	0	0	0	0	0	1	18252	610	22	4		4	ZNF831	20	57767313	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	12636159	57767313	5258207	139	27048											
CCT8L2	150160	broad.mit.edu	37	chr22	17072462	17072462	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgtgtccaacacctcacTcaggtaaatgatctccatcc	11	10	7	13	0	3	1	2	1	1	0	6	1	5	1	4	2	1	1	4	2	3	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr22:17072462T>A	uc002zlp.1	-	1	1239	c.979A>T	c.(979-981)AGT>TGT	p.S327C		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	327					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AACACCTCACTCAGGTAAATG	0.577													28	221					0	0	0	0	A	17072462	A	A	17072462	3	1	147	1	0	0	0	0	1	0	0	0	2976	1551	54	5	698	5	CCT8L2	22	17072462	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08		17072462	34232104	140	27049											
LZTR1	8216	broad.mit.edu	37	chr22	21348279	21348279	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgctggcttcgcaggaagAtcacgcaggcgcgggagagg	8	4	18	11	5	1	2	1	0	0	2	2	4	1	3	1	5	0	4	1	5	1	1			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr22:21348279A>G	uc002zto.2	+	13	1523	c.1420A>G	c.(1420-1422)ATC>GTC	p.I474V	LZTR1_uc002ztn.2_Missense_Mutation_p.I433V|LZTR1_uc011ahy.1_Missense_Mutation_p.I455V|LZTR1_uc010gsr.1_Missense_Mutation_p.I345V|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	474	BTB 1.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TCGCAGGAAGATCACGCAGGC	0.647													6	31					0	0	0	0	G	21348279	G	G	21348279	3	3	147	1	0	0	0	0	1	0	0	0	9188	333	12	5	1470	5	LZTR1	22	21348279	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08	4275817	21348279	29956287	141	27050											
AP1B1	162	broad.mit.edu	37	chr22	29754833	29754833	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagctgctgtcttgcgcacaTatggatcctcgtccttcagg	6	12	10	13	2	2	0	1	0	1	0	5	1	4	1	2	2	3	3	2	2	1	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr22:29754833T>A	uc003afj.2	-	5	591	c.407A>T	c.(406-408)TAT>TTT	p.Y136F	AP1B1_uc003afi.2_Missense_Mutation_p.Y136F|AP1B1_uc003afk.2_Missense_Mutation_p.Y136F|AP1B1_uc003afl.2_Missense_Mutation_p.Y136F	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	136					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CTTGCGCACATATGGATCCTC	0.602													11	40					0	0	0	0	A	29754833	A	A	29754833	3	1	147	1	0	0	0	0	1	0	0	0	731	1406	49	5	2518	5	AP1B1	22	29754833	Missense_Mutation	SNP	T	TCGA-CR-7377-01A-11D-2012-08	8406554	29754833	21549733	142	27051											
MPPED1	758	broad.mit.edu	37	chr22	43830954	43830954	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtgtcatctctccctgcagGgtggacccggtgcctcacga	6	9	12	14	2	3	0	2	0	1	0	5	2	4	1	3	3	2	1	3	3	0	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr22:43830954G>A	uc011apv.1	+	3	448	c.225G>A	c.(223-225)ATG>ATA	p.M75I	MPPED1_uc011apw.1_5'UTR|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Missense_Mutation_p.M75I|MPPED1_uc011apz.1_Missense_Mutation_p.M108I	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	75							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				CTCCCTGCAGGGTGGACCCGG	0.647													15	150					0	0	0	0	A	43830954	A	A	43830954	3	1	147	1	0	0	0	0	1	0	0	0	9794	1246	43	4	231	4	MPPED1	22	43830954	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	14076121	43830954	7473612	143	27052											
PLXNB2	23654	broad.mit.edu	37	chr22	50720046	50720046	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtttctgccgccgcttgggCgggggctgcacctccggggg	1	8	18	14	5	1	0	0	0	1	0	2	0	2	0	4	5	2	4	4	5	0	2			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chr22:50720046C>T	uc003bkv.3	-	21	3577	c.3471G>A	c.(3469-3471)CCG>CCA	p.P1157P	PLXNB2_uc003bkt.1_5'UTR|PLXNB2_uc003bku.1_Silent_p.P142P	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1157	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCGCTTGGGCGGGGGCTGCA	0.692													10	67					0	0	0	0	T	50720046	T	T	50720046	2	4	147	1	0	0	0	0	0	0	0	1	12179	755	27	1		1	PLXNB2	22	50720046	Silent	SNP	C	TCGA-CR-7377-01A-11D-2012-08	6889092	50720046	584520	144	27053											
ALAS2	212	broad.mit.edu	37	chrX	55042039	55042039	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccagagatgatgtcaatcttAtgcataattccatcacgctc	12	12	6	11	1	3	2	2	1	1	1	5	3	4	2	2	0	1	2	2	0	3	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chrX:55042039A>C	uc004dua.3	-	8	1278	c.1140T>G	c.(1138-1140)CAT>CAG	p.H380Q	ALAS2_uc004dub.3_Missense_Mutation_p.H367Q|ALAS2_uc004dud.3_Missense_Mutation_p.H343Q	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	380					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	TGTCAATCTTATGCATAATTC	0.517													10	39					0	0	0	0	C	55042039	C	C	55042039	3	2	147	1	0	0	0	0	1	0	0	0	485	446	16	5	639	5	ALAS2	23	55042039	Missense_Mutation	SNP	A	TCGA-CR-7377-01A-11D-2012-08		55042039	100228521	145	27054											
TAF1	6872	broad.mit.edu	37	chrX	70604857	70604857	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaactgtttactgccatacAtctcctttcctgggttctct	7	16	6	12	0	2	0	0	0	2	0	5	1	3	0	3	1	4	2	3	1	3	5			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chrX:70604857A>G	uc004dzu.3	+	14	2232	c.2181A>G	c.(2179-2181)ACA>ACG	p.T727T	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Silent_p.T748T	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	727					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				ACTGCCATACATCTCCTTTCC	0.393													11	38					0	0	0	0	G	70604857	G	G	70604857	2	3	147	1	0	0	0	0	0	0	0	1	15579	204	8	5		5	TAF1	23	70604857	Silent	SNP	A	TCGA-CR-7377-01A-11D-2012-08	15562818	70604857	84665703	146	27055											
RGAG1	57529	broad.mit.edu	37	chrX	109696314	109696314	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccatgtctgctccacaaatGacagccacagcctctggaat	11	8	8	14	0	2	1	0	1	2	0	3	2	3	2	4	1	3	1	4	1	2	0			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chrX:109696314G>A	uc004eor.1	+	3	2715	c.2469G>A	c.(2467-2469)ATG>ATA	p.M823I	RGAG1_uc011msr.1_Missense_Mutation_p.M823I	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	823										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CTCCACAAATGACAGCCACAG	0.532													31	91					0	0	0	0	A	109696314	A	A	109696314	3	1	147	1	0	0	0	0	1	0	0	0	13339	1290	45	2	2471	2	RGAG1	23	109696314	Missense_Mutation	SNP	G	TCGA-CR-7377-01A-11D-2012-08	39091457	109696314	45574246	147	27056											
ATP11C	286410	broad.mit.edu	37	chrX	138886713	138886713	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgatagaagaataagatCacagggaaaggtttcatctg	17	9	11	4	0	3	5	2	1	1	4	3	6	3	6	0	2	0	1	0	2	5	3			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chrX:138886713C>A	uc004faz.2	-	6	580	c.481G>T	c.(481-483)GAT>TAT	p.D161Y	ATP11C_uc004fba.2_Missense_Mutation_p.D161Y	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	161	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					AGAATAAGATCACAGGGAAAG	0.368													17	81					1.56452e-12	1.96497e-12	1	0	A	138886713	A	A	138886713	3	1	147	1	0	0	0	0	1	0	0	0	1123	826	29	2	3080	2	ATP11C	23	138886713	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	29190399	138886713	16383847	148	27057											
SLITRK2	84631	broad.mit.edu	37	chrX	144904539	144904539	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctaaaagtaatgccttttgCtggcgtccttgaacatattg	10	14	9	8	1	0	1	0	1	0	0	1	1	1	1	2	1	3	3	2	1	5	7			TCGA-CR-7377-01A-11D-2012-08	TCGA-CR-7377-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	93e4eb9a-7643-411b-be90-94b801f23566	93f4434d-0de9-466f-a47f-6b774b51c44e	g.chrX:144904539C>T	uc004fcd.2	+	5	1586	c.596C>T	c.(595-597)GCT>GTT	p.A199V	SLITRK2_uc010nsp.2_Missense_Mutation_p.A199V|SLITRK2_uc010nso.2_Missense_Mutation_p.A199V|SLITRK2_uc011mwq.1_Missense_Mutation_p.A199V|SLITRK2_uc011mwr.1_Missense_Mutation_p.A199V|SLITRK2_uc011mws.1_Missense_Mutation_p.A199V|SLITRK2_uc004fcg.2_Missense_Mutation_p.A199V|SLITRK2_uc011mwt.1_Missense_Mutation_p.A199V	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	199	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					ATGCCTTTTGCTGGCGTCCTT	0.483													22	79					0	0	0	0	T	144904539	T	T	144904539	3	4	147	1	0	0	0	0	1	0	0	0	14807	797	28	4	598	4	SLITRK2	23	144904539	Missense_Mutation	SNP	C	TCGA-CR-7377-01A-11D-2012-08	6017826	144904539	10366021	149	27058											
HSPG2	3339	broad.mit.edu	37	chr1	22173889	22173889	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagacggagatgacgatggAggcctccagggcatcgatgt	10	6	17	8	3	0	3	0	1	0	2	2	8	1	4	2	5	0	1	2	5	0	0			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:22173889A>G	uc001bfj.2	-	62	8162	c.8122T>C	c.(8122-8124)TCC>CCC	p.S2708P	HSPG2_uc009vqd.2_Missense_Mutation_p.S2709P	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2708	Ig-like C2-type 12.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	ATGACGATGGAGGCCTCCAGG	0.627													3	99					0	0	0	0	G	22173889	G	G	22173889	3	3	148	1	0	0	0	0	1	0	0	0	7469	304	11	5	5197	5	HSPG2	1	22173889	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08		22173889	227076732	1	27059											
SYTL1	84958	broad.mit.edu	37	chr1	27676942	27676942	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagacggcggtgaagaaacGgaatctgaatccggttttca	13	8	12	8	4	2	4	1	2	1	2	3	5	3	5	1	4	1	1	1	4	5	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:27676942G>A	uc001bnw.1	+	10	1138	c.971G>A	c.(970-972)CGG>CAG	p.R324Q	SYTL1_uc001bnv.1_Missense_Mutation_p.R312Q|SYTL1_uc009vsu.1_Missense_Mutation_p.R312Q|SYTL1_uc001bnx.2_3'UTR|SYTL1_uc009vsv.1_Missense_Mutation_p.R324Q	NM_032872	NP_116261	Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	324	C2 1.				exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			ovary(1)	1		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GTGAAGAAACGGAATCTGAAT	0.602													42	56					0	0	0	0	A	27676942	A	A	27676942	3	1	148	1	0	0	0	0	1	0	0	0	15548	1116	39	1	969	1	SYTL1	1	27676942	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	5503053	27676942	221573679	2	27060											
PTPRU	10076	broad.mit.edu	37	chr1	29650167	29650167	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggaggggcacctgctggtgCggcacttccagttcctgcgc	5	8	15	13	2	0	0	0	0	0	0	2	1	2	1	3	5	3	4	3	5	0	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:29650167C>T	uc001bru.2	+	29	4119	c.4009C>T	c.(4009-4011)CGG>TGG	p.R1337W	PTPRU_uc001brv.2_Missense_Mutation_p.R1333W|PTPRU_uc001brw.2_Missense_Mutation_p.R1327W|PTPRU_uc009vtq.2_Missense_Mutation_p.R1331W|PTPRU_uc009vtr.2_Missense_Mutation_p.R1324W|PTPRU_uc001brx.2_Missense_Mutation_p.R63W	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1337	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CCTGCTGGTGCGGCACTTCCA	0.642													31	26					0	0	0	0	T	29650167	T	T	29650167	3	4	148	1	0	0	0	0	1	0	0	0	12878	759	27	1	4145	1	PTPRU	1	29650167	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	1973225	29650167	219600454	3	27061											
PTPRF	5792	broad.mit.edu	37	chr1	44085815	44085815	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcctctggcagagagcaccGaggacttctggcgcatgcta	8	7	14	12	2	2	1	0	0	2	1	2	4	2	2	2	4	2	4	2	4	1	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:44085815G>A	uc001cjr.2	+	30	5501	c.5161G>A	c.(5161-5163)GAG>AAG	p.E1721K	PTPRF_uc001cjs.2_Missense_Mutation_p.E1712K|PTPRF_uc001cju.2_Missense_Mutation_p.E1110K|PTPRF_uc009vwt.2_Missense_Mutation_p.E1281K|PTPRF_uc001cjv.2_Missense_Mutation_p.E1192K|PTPRF_uc001cjw.2_Missense_Mutation_p.E947K	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1721	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity	p.E1711Q(1)		ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGAGAGCACCGAGGACTTCTG	0.592													70	60					0	0	0	0	A	44085815	A	A	44085815	3	1	148	1	0	0	0	0	1	0	0	0	12866	1059	37	1	5271	1	PTPRF	1	44085815	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	14435648	44085815	205164806	4	27062											
DDX20	11218	broad.mit.edu	37	chr1	112303130	112303130	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcatagaacttgactacttGaacccaggcagtatacgcct	12	10	7	12	1	1	3	1	2	0	1	1	3	1	3	2	1	4	2	2	1	6	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:112303130G>A	uc001ebs.2	+	4	957	c.600G>A	c.(598-600)TTG>TTA	p.L200L	DDX20_uc010owf.1_5'UTR|DDX20_uc001ebt.2_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	200	Helicase ATP-binding.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGACTACTTGAACCCAGGCA	0.308													56	64					0	0	0	0	A	112303130	A	A	112303130	2	1	148	1	0	0	0	0	0	0	0	1	4365	1281	45	2		2	DDX20	1	112303130	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	68217315	112303130	136947491	5	27063											
MAGI3	260425	broad.mit.edu	37	chr1	114215339	114215339	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgacaccgcagtaatttcAgttgtaggcagtcggcacaa	11	9	10	11	2	1	1	1	1	0	0	2	1	1	1	2	2	0	6	2	2	3	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:114215339A>G	uc001edk.2	+	18	3202	c.3021A>G	c.(3019-3021)TCA>TCG	p.S1007S	MAGI3_uc001edh.3_Silent_p.S1032S|MAGI3_uc001edi.3_Silent_p.S1007S|MAGI3_uc010owm.1_Silent_p.S1032S|MAGI3_uc001edj.2_Silent_p.S728S	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1032					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGTAATTTCAGTTGTAGGCA	0.448													4	261					0	0	0	0	G	114215339	G	G	114215339	2	3	148	1	0	0	0	0	0	0	0	1	9245	175	7	5		5	MAGI3	1	114215339	Silent	SNP	A	TCGA-CR-7379-01A-11D-2012-08	1912209	114215339	135035282	6	27064											
PEX11B	8799	broad.mit.edu	37	chr1	145522726	145522726	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcggctgcaagtcctgcTcctggctcgagtccttagag	6	11	11	13	2	0	1	0	0	0	1	5	2	3	1	3	2	2	4	3	2	2	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:145522726T>G	uc001eny.1	+	4	605	c.587T>G	c.(586-588)CTC>CGC	p.L196R	NBPF10_uc001emp.3_Intron|PEX11B_uc010oyu.1_Missense_Mutation_p.L182R|ITGA10_uc001enz.1_5'Flank|ITGA10_uc001eoa.2_5'Flank|ITGA10_uc010oyv.1_5'Flank|ITGA10_uc009wiw.2_5'Flank	NM_003846	NP_003837	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	196					peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CAAGTCCTGCTCCTGGCTCGA	0.582													3	92					0	0	0	0	G	145522726	G	G	145522726	3	3	148	1	0	0	0	0	1	0	0	0	11793	1551	54	5	619	5	PEX11B	1	145522726	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	31307387	145522726	103727895	7	27065											
RPRD2	23248	broad.mit.edu	37	chr1	150445676	150445676	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtataatcttacggagtcccCggccagactttcggcctagg	8	10	11	12	3	1	1	0	0	1	1	3	2	2	2	4	4	1	1	4	4	4	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:150445676C>T	uc009wlr.2	+	11	4453	c.4252C>T	c.(4252-4254)CGG>TGG	p.R1418W	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Missense_Mutation_p.R1392W	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1418	Pro-rich.						protein binding			ovary(1)	1						ACGGAGTCCCCGGCCAGACTT	0.582													76	47					0	0	0	0	T	150445676	T	T	150445676	3	4	148	1	0	0	0	0	1	0	0	0	13682	643	23	1	4294	1	RPRD2	1	150445676	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	4922950	150445676	98804945	8	27066											
ATP1A4	480	broad.mit.edu	37	chr1	160141474	160141474	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacctttgttttgtgggccTcatatccatgattgaccctc	7	15	7	12	0	1	2	1	2	0	0	3	2	2	2	4	1	1	1	4	1	2	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:160141474T>C	uc001fve.3	+	12	2260	c.1781T>C	c.(1780-1782)CTC>CCC	p.L594P	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.L97P	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	594	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TTTGTGGGCCTCATATCCATG	0.488													3	192					0	0	0	0	C	160141474	C	C	160141474	3	2	148	1	0	0	0	0	1	0	0	0	1133	1551	54	5	1827	5	ATP1A4	1	160141474	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	9695798	160141474	89109147	9	27067											
SELP	6403	broad.mit.edu	37	chr1	169580906	169580906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggggcttccaggtgctgaCactgcacagctggagagaat	9	8	15	9	0	0	2	0	1	0	1	1	4	1	3	1	4	3	4	1	4	1	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:169580906C>T	uc001ggi.3	-	7	1036	c.971G>A	c.(970-972)TGT>TAT	p.C324Y	SELP_uc001ggh.2_Missense_Mutation_p.C159Y|SELP_uc009wvr.2_Missense_Mutation_p.C324Y	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	324	Sushi 3.|Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CAGGTGCTGACACTGCACAGC	0.507													54	61					0	0	0	0	T	169580906	T	T	169580906	3	4	148	1	0	0	0	0	1	0	0	0	14084	478	17	4	1561	4	SELP	1	169580906	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	9439432	169580906	79669715	10	27068											
METTL13	51603	broad.mit.edu	37	chr1	171753042	171753042	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcttgaagatggacatgAcgcagatggagtttcctgat	10	12	12	7	1	1	5	0	3	1	2	2	7	2	7	1	2	0	3	1	2	1	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:171753042A>C	uc001ghz.2	+	2	663	c.316A>C	c.(316-318)ACG>CCG	p.T106P	METTL13_uc001gia.2_Missense_Mutation_p.T20P|METTL13_uc001gib.2_Missense_Mutation_p.T106P|METTL13_uc010pml.1_Missense_Mutation_p.T105P	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	106							methyltransferase activity|protein binding			kidney(1)	1						GATGGACATGACGCAGATGGA	0.502													42	32					0	0	0	0	C	171753042	C	C	171753042	3	2	148	1	0	0	0	0	1	0	0	0	9550	275	10	5	322	5	METTL13	1	171753042	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	2172136	171753042	77497579	11	27069											
SPATA17	128153	broad.mit.edu	37	chr1	217856693	217856693	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtcgtttcagagaccaatGatgcaattaggtaagtagtg	14	11	11	5	1	1	2	1	1	0	1	2	3	1	2	1	1	1	4	1	1	6	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:217856693G>T	uc001hlh.1	+	5	411	c.385G>T	c.(385-387)GAT>TAT	p.D129Y	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.D129Y	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	129						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		AGAGACCAATGATGCAATTAG	0.343													61	60					4.09171e-25	1.09853e-24	1	0	T	217856693	T	T	217856693	3	4	148	1	0	0	0	0	1	0	0	0	15068	1290	45	2	403	2	SPATA17	1	217856693	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	46103651	217856693	31393928	12	27070											
VN1R5	317705	broad.mit.edu	37	chr1	247420369	247420369	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaatattcaagactctgcaAatgttatggtttaaatattt	15	16	5	5	0	2	1	1	0	1	1	2	1	2	1	0	1	1	3	0	1	8	7			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr1:247420369A>C	uc010pyu.1	+	2	996	c.996A>C	c.(994-996)CAA>CAC	p.Q332H		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	332	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			AGACTCTGCAAAtgttatggt	0.209													4	37					0	0	0	0	C	247420369	C	C	247420369	3	2	148	1	0	0	0	0	1	0	0	0	17249	11	1	5	998	5	VN1R5	1	247420369	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	29563676	247420369	1830252	13	27071											
PSD4	23550	broad.mit.edu	37	chr2	113949982	113949982	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgaggacaccgatgaacTcttcttggcttcctgggagc	8	11	11	11	1	3	2	0	2	3	0	4	5	4	4	2	3	2	1	2	3	1	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:113949982T>A	uc002tjc.2	+	6	1837	c.1654T>A	c.(1654-1656)TCT>ACT	p.S552T	PSD4_uc002tjd.2_Missense_Mutation_p.S173T|PSD4_uc002tje.2_Missense_Mutation_p.S523T|PSD4_uc002tjf.2_Missense_Mutation_p.S173T	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	552	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						ACCGATGAACTCTTCTTGGCT	0.547													84	146					0	0	0	0	A	113949982	A	A	113949982	3	1	148	1	0	0	0	0	1	0	0	0	12711	1551	54	5	1672	5	PSD4	2	113949982	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08		113949982	129249391	14	27072											
TTN	7273	broad.mit.edu	37	chr2	179472661	179472661	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgatcatcttctctgtgcagCgtgaccattcatttgtgcca	7	15	8	11	1	4	2	2	2	2	0	5	2	4	2	2	0	3	1	2	0	0	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:179472661C>T	uc010zfg.1	-	225	45373	c.45149G>A	c.(45148-45150)CGC>CAC	p.R15050H	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R8745H|TTN_uc010zfi.1_Missense_Mutation_p.R8678H|TTN_uc010zfj.1_Missense_Mutation_p.R8553H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15977							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTGTGCAGCGTGACCATTC	0.478													34	103					0	0	0	0	T	179472661	T	T	179472661	3	4	148	1	0	0	0	0	1	0	0	0	16803	768	27	1	55188	1	TTN	2	179472661	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	65522679	179472661	63726712	15	27073											
CASP8	841	broad.mit.edu	37	chr2	202131228	202131228	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatggacttcagcagaaatCtttatgatattggggaacaa	15	11	10	5	0	2	3	1	1	1	2	2	5	2	5	0	3	2	1	0	3	5	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:202131228C>G	uc002uxr.1	+	3	228	c.19C>G	c.(19-21)CTT>GTT	p.L7V	CASP8_uc010ftc.1_Missense_Mutation_p.L7V|CASP8_uc002uxo.1_Missense_Mutation_p.L7V|CASP8_uc002uxp.1_Missense_Mutation_p.L7V|CASP8_uc002uxq.1_Missense_Mutation_p.L7V|CASP8_uc002uxs.1_Missense_Mutation_p.L7V|CASP8_uc002uxt.1_Missense_Mutation_p.L66V|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.L7V|CASP8_uc002uxw.1_Missense_Mutation_p.L7V|CASP8_uc002uxy.1_Missense_Mutation_p.L7V|CASP8_uc002uxx.1_Missense_Mutation_p.L7V|CASP8_uc010ftf.2_Missense_Mutation_p.L7V	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	7	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CAGCAGAAATCTTTATGATAT	0.408										HNSCC(4;0.00038)			16	43					0	0	0	0	G	202131228	G	G	202131228	3	3	148	1	0	0	0	0	1	0	0	0	2689	913	32	2	202	2	CASP8	2	202131228	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	22658567	202131228	41068145	16	27074											
ALS2	57679	broad.mit.edu	37	chr2	202625656	202625656	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcctctcttactgaatgaTctgacagtttccgtaggtat	9	15	8	9	1	2	3	0	3	2	0	5	3	4	3	2	1	1	3	2	1	4	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:202625656T>A	uc002uyo.2	-	4	1417	c.1061A>T	c.(1060-1062)GAT>GTT	p.D354V	ALS2_uc002uyp.3_Missense_Mutation_p.D354V|ALS2_uc002uyq.2_Missense_Mutation_p.D354V|ALS2_uc002uyr.2_Missense_Mutation_p.D354V	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	354					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TACTGAATGATCTGACAGTTT	0.413													17	74					0	0	0	0	A	202625656	A	A	202625656	3	1	148	1	0	0	0	0	1	0	0	0	550	1435	50	5	4114	5	ALS2	2	202625656	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	494428	202625656	40573717	17	27075											
ERBB4	2066	broad.mit.edu	37	chr2	212488657	212488657	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttttacttactttataaaccGttccaaaagcacctgagcca	13	13	4	11	1	0	1	0	1	0	0	1	1	1	1	4	0	5	2	4	0	7	7			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:212488657G>A	uc002veg.1	-	18	2290	c.2192C>T	c.(2191-2193)ACG>ATG	p.T731M	ERBB4_uc002veh.1_Missense_Mutation_p.T731M|ERBB4_uc010zji.1_Missense_Mutation_p.T721M|ERBB4_uc010zjj.1_Missense_Mutation_p.T721M|ERBB4_uc010fut.1_Missense_Mutation_p.T731M	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	731	ATP (By similarity).|Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TTTATAAACCGTTCCAAAAGC	0.363										TSP Lung(8;0.080)			11	49					0	0	0	0	A	212488657	A	A	212488657	3	1	148	1	0	0	0	0	1	0	0	0	5233	1145	40	1	1778	1	ERBB4	2	212488657	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	9863001	212488657	30710716	18	27076											
ERBB4	2066	broad.mit.edu	37	chr2	212568852	212568852	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagagtactcttccaccaatGgtcaccaggttagaaaaaac	15	9	7	10	0	2	2	1	0	1	2	3	2	3	2	3	2	2	2	3	2	7	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:212568852G>A	uc002veg.1	-	11	1364	c.1266C>T	c.(1264-1266)ACC>ACT	p.T422T	ERBB4_uc002veh.1_Silent_p.T422T|ERBB4_uc010zji.1_Silent_p.T422T|ERBB4_uc010zjj.1_Silent_p.T422T|ERBB4_uc010fut.1_Silent_p.T422T	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	422	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TTCCACCAATGGTCACCAGGT	0.393										TSP Lung(8;0.080)			21	80					0	0	0	0	A	212568852	A	A	212568852	2	1	148	1	0	0	0	0	0	0	0	1	5233	1335	47	4		4	ERBB4	2	212568852	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	80195	212568852	30630521	19	27077											
ASB18	401036	broad.mit.edu	37	chr2	237172797	237172797	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggttacctagcagcatgccGgtgggcagctgagccgaggg	7	7	17	10	2	0	1	0	1	0	0	0	2	0	1	3	4	6	5	3	4	2	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr2:237172797G>A	uc010znh.1	-	1	192	c.192C>T	c.(190-192)ACC>ACT	p.T64T		NM_212556	NP_997721	Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box-containing 18	64					intracellular signal transduction					ovary(1)	1		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		GCAGCATGCCGGTGGGCAGCT	0.527													4	33					0	0	0	0	A	237172797	A	A	237172797	2	1	148	1	0	0	0	0	0	0	0	1	1024	1103	39	1		1	ASB18	2	237172797	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	24603945	237172797	6026576	20	27078											
SETMAR	6419	broad.mit.edu	37	chr3	4355272	4355272	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaggctagatcatgggaaaCtaaggaaaccttgttactgt	15	10	10	6	0	1	1	1	0	0	1	1	3	1	3	1	3	3	2	1	3	6	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:4355272C>G	uc011asp.1	+	2	914	c.847C>G	c.(847-849)CTA>GTA	p.L283V	SUMF1_uc003bps.1_Intron|SETMAR_uc003bpw.3_Missense_Mutation_p.L270V|SETMAR_uc003bpy.3_Intron|SETMAR_uc011asq.1_Intron|SETMAR_uc011asr.1_Intron|SETMAR_uc010hbx.2_Missense_Mutation_p.L78V	NM_006515	NP_006506	Q53H47	SETMR_HUMAN	SET domain and mariner transposase fusion	270	Post-SET.|Histone-lysine N-methyltransferase.				DNA integration|DNA repair|transposition, DNA-mediated	chromosome|nucleus	DNA binding|endonuclease activity|histone-lysine N-methyltransferase activity|transposase activity|zinc ion binding			ovary(1)	1		Melanoma(143;0.0657)		Epithelial(13;0.0025)|OV - Ovarian serous cystadenocarcinoma(96;0.011)|all cancers(10;0.0114)		TCATGGGAAACTAAGGAAACC	0.403								Chromatin_Structure|Direct_reversal_of_damage					10	34					0	0	0	0	G	4355272	G	G	4355272	3	3	148	1	0	0	0	0	1	0	0	0	14205	564	20	4	853	4	SETMAR	3	4355272	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08		4355272	193667158	21	27079											
SLMAP	7871	broad.mit.edu	37	chr3	57898145	57898145	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacatcgatactgagaatctCcgggaggagaaggacagtga	14	6	13	8	2	1	3	0	2	1	2	3	8	1	5	1	3	1	0	1	3	3	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:57898145C>T	uc003dje.1	+	18	1891	c.1686C>T	c.(1684-1686)CTC>CTT	p.L562L	SLMAP_uc003djd.1_Silent_p.L545L|SLMAP_uc003djf.1_Silent_p.L524L|SLMAP_uc003djg.1_Silent_p.L156L|SLMAP_uc011bez.1_Silent_p.L30L|SLMAP_uc011bfa.1_Silent_p.L96L|SLMAP_uc003djh.2_Silent_p.L55L|SLMAP_uc003dji.1_Silent_p.L96L|SLMAP_uc011bfb.1_Silent_p.L96L|SLMAP_uc011bfc.1_Silent_p.L55L	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	562	Cytoplasmic (Potential).|Potential.				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		CTGAGAATCTCCGGGAGGAGA	0.413													11	56					0	0	0	0	T	57898145	T	T	57898145	2	4	148	1	0	0	0	0	0	0	0	1	14813	842	30	2		2	SLMAP	3	57898145	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	53542873	57898145	140124285	22	27080											
ZNF654	55279	broad.mit.edu	37	chr3	88188748	88188750	+	In_Frame_Del	DEL	TAC	-	-																															gatttggaagtggagacactTactgcttctagtgaaggaaa																										TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:88188748_88188750delTAC	uc003dqv.2	+	1	487_489	c.288_290delTAC	c.(286-291)CTTACT>CTT	p.T97del	CGGBP1_uc003dqu.2_Intron	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TGGAGACACTTACTGCTTCTAGT	0.34													---	---	---								-	88188750	-	-	88188748	7	5	148	1	0	1	0	1	0	0	0	0	18134	1741	61	0	290	0	ZNF654	3	88188748	In_Frame_Del	DEL	TAC	TCGA-CR-7379-01A-11D-2012-08	30290603	88188748	109833682	23	27081											
OR5H14	403273	broad.mit.edu	37	chr3	97868899	97868899	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttacatatttgtcctctatAcaatcttgaaaaagaagtct	14	15	4	8	0	3	2	0	1	3	1	4	2	4	2	1	0	2	0	1	0	8	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:97868899A>C	uc003dsg.1	+	1	670	c.670A>C	c.(670-672)ACA>CCA	p.T224P		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGTCCTCTATACAATCTTGAA	0.358													3	38					0	0	0	0	C	97868899	C	C	97868899	3	2	148	1	0	0	0	0	1	0	0	0	11214	391	14	5	672	5	OR5H14	3	97868899	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	9680151	97868899	100153531	24	27082											
OR5H6	79295	broad.mit.edu	37	chr3	97983841	97983841	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatatcttatacaattatccTctttacaatcttagaaaaga	16	16	2	7	0	3	2	0	0	3	2	4	2	4	2	1	0	2	0	1	0	11	8			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:97983841T>C	uc003dsi.1	+	1	713	c.713T>C	c.(712-714)CTC>CCC	p.L238P		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	238	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						ACAATTATCCTCTTTACAATC	0.353													4	35					0	0	0	0	C	97983841	C	C	97983841	3	2	148	1	0	0	0	0	1	0	0	0	11217	1551	54	5	715	5	OR5H6	3	97983841	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	114942	97983841	100038589	25	27083											
HHLA2	11148	broad.mit.edu	37	chr3	108072558	108072558	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtaagccttctggacgaaGgaatttacacctgctatgta	12	11	10	8	1	1	0	0	0	1	0	1	4	1	2	2	2	3	3	2	2	6	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:108072558G>A	uc003dwy.3	+	4	516	c.349G>A	c.(349-351)GGA>AGA	p.G117R	HHLA2_uc011bhl.1_Missense_Mutation_p.G53R|HHLA2_uc010hpu.2_Missense_Mutation_p.G117R|HHLA2_uc003dwz.2_Missense_Mutation_p.G117R	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	117	Ig-like V-type 1.					integral to membrane				ovary(1)	1						TCTGGACGAAGGAATTTACAC	0.403													15	34					0	0	0	0	A	108072558	A	A	108072558	3	1	148	1	0	0	0	0	1	0	0	0	7134	1001	35	4	355	4	HHLA2	3	108072558	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	10088717	108072558	89949872	26	27084											
IGSF10	285313	broad.mit.edu	37	chr3	151161398	151161398	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actgtttggtttgcaagaatCcaggtaactgtagggcttgg	9	13	13	6	0	0	1	0	0	0	1	1	1	1	1	1	4	2	6	1	4	4	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr3:151161398C>A	uc011bod.1	-	5	5337	c.5337G>T	c.(5335-5337)TGG>TGT	p.W1779C	IGSF10_uc011bob.1_5'Flank|IGSF10_uc011boc.1_5'Flank	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1779	Ig-like C2-type 4.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTGCAAGAATCCAGGTAACTG	0.498													16	93					9.16793e-09	2.32254e-08	1	0	A	151161398	A	A	151161398	3	1	148	1	0	0	0	0	1	0	0	0	7636	856	30	2	2590	2	IGSF10	3	151161398	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	43088840	151161398	46861032	27	27085											
DOK7	285489	broad.mit.edu	37	chr4	3494760	3494783	+	In_Frame_Del	DEL	CAGCAGCCTCTCGTCCTACGCGGG	-	-																															ggcagccactcctcttactcCagcagcctctcgtcctacgc																										TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:3494760_3494783delCAGCAGCCTCTCGTCCTACGCGGG	uc003ghd.2	+	7	1117_1140	c.1047_1070delCAGCAGCCTCTCGTCCTACGCGGG	c.(1045-1071)TCCAGCAGCCTCTCGTCCTACGCGGGC>TCC	p.SSLSSYAG350del	DOK7_uc003ghe.2_In_Frame_Del_p.SSLSSYAG212del|DOK7_uc003ghf.2_In_Frame_Del_p.AASRPTRA92del|DOK7_uc003ghg.1_In_Frame_Del_p.SSLSSYAG40del	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	350_357	Ser-rich.				positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCTCTTACTCCAGCAGCCTCTCGTCCTACGCGGGCAGCAGCCTG	0.714													---	---	---								-	3494783	-	-	3494760	7	5	148	1	0	1	0	1	0	0	0	0	4724	581	21	0	1073	0	DOK7	4	3494760	In_Frame_Del	DEL	CAGCAGCCTCTCGTCCTACGCGGG	TCGA-CR-7379-01A-11D-2012-08		3494760	187659516	28	27086											
MSX1	4487	broad.mit.edu	37	chr4	4864759	4864759	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagctgtagcggccgcggcGggtgcctcgctctacggtgc	3	7	17	14	6	1	0	0	0	1	0	2	0	1	0	2	4	5	4	2	4	2	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:4864759G>T	uc003gif.2	+	2	1036	c.801G>T	c.(799-801)GCG>GCT	p.A267A		NM_002448	NP_002439	P28360	MSX1_HUMAN	msh homeobox 1	261	Poly-Ala.				apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CGGCCGCGGCGGGTGCCTCGC	0.706													6	18					5.9392e-07	1.46698e-06	1	0	T	4864759	T	T	4864759	2	4	148	1	0	0	0	0	0	0	0	1	9948	1103	39	3		3	MSX1	4	4864759	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	1369999	4864759	186289517	29	27087											
AIMP1	9255	broad.mit.edu	37	chr4	107252981	107252981	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgtggaagaagtagatgtcGgagaaatagccccaaggaca	16	6	13	6	1	0	3	0	0	0	3	1	6	0	5	2	3	1	1	2	3	6	2	rs148281523		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:107252981G>A	uc011cfg.1	+	5	596	c.544G>A	c.(544-546)GGA>AGA	p.G182R	AIMP1_uc003hyg.2_Missense_Mutation_p.G182R|AIMP1_uc003hyh.2_Missense_Mutation_p.G206R	NM_001142415	NP_001135887	Q12904	AIMP1_HUMAN	small inducible cytokine subfamily E, member 1	182	tRNA-binding.|Interaction with HSP90B1 (By similarity).|Required for endothelial cell migration.				angiogenesis|apoptosis|cell adhesion|cell-cell signaling|chemotaxis|glucose metabolic process|inflammatory response|leukocyte migration|negative regulation of endothelial cell proliferation|signal transduction|tRNA aminoacylation for protein translation	aminoacyl-tRNA synthetase multienzyme complex|cytosol|endoplasmic reticulum|extracellular space|Golgi apparatus|nucleus|transport vesicle	cell surface binding|cytokine activity|protein homodimerization activity|tRNA binding				0						AGTAGATGTCGGAGAAATAGC	0.428													27	189					0	0	0	0	A	107252981	A	A	107252981	3	1	148	1	0	0	0	0	1	0	0	0	433	1117	39	1	634	1	AIMP1	4	107252981	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	102388222	107252981	83901295	30	27088											
FAT4	79633	broad.mit.edu	37	chr4	126241670	126241670	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttttagcattagcccaaaCactgggagtatttttcttgc	10	15	7	9	0	1	0	0	0	1	0	1	1	1	1	1	1	4	2	1	1	4	7			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:126241670C>T	uc003ifj.3	+	1	4104	c.4104C>T	c.(4102-4104)AAC>AAT	p.N1368N		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1368	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TTAGCCCAAACACTGGGAGTA	0.378													21	72					0	0	0	0	T	126241670	T	T	126241670	2	4	148	1	0	0	0	0	0	0	0	1	5724	477	17	4		4	FAT4	4	126241670	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	18988689	126241670	64912606	31	27089											
FBXW7	55294	broad.mit.edu	37	chr4	153247226	153247226	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttcagtctctggatcccAcacctttaccataaaatcat	11	13	5	12	0	3	0	2	0	1	0	5	1	4	1	3	2	1	1	3	2	3	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:153247226A>G	uc003ims.2	-	10	1725	c.1576T>C	c.(1576-1578)TGG>CGG	p.W526R	FBXW7_uc011cii.1_Missense_Mutation_p.W526R|FBXW7_uc003imt.2_Missense_Mutation_p.W526R|FBXW7_uc011cih.1_Missense_Mutation_p.W350R|FBXW7_uc003imq.2_Missense_Mutation_p.W446R|FBXW7_uc003imr.2_Missense_Mutation_p.W408R	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	526	WD 4.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.W526R(2)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TCTGGATCCCACACCTTTACC	0.428			Mis|N|D|F		colorectal|endometrial|T-ALL								16	89					0	0	0	0	G	153247226	G	G	153247226	3	3	148	1	0	0	0	0	1	0	0	0	5801	159	6	5	559	5	FBXW7	4	153247226	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	27005556	153247226	37907050	32	27090											
FBXW7	55294	broad.mit.edu	37	chr4	153259045	153259046	+	Frame_Shift_Ins	INS	-	TGAGT	TGAGT																															tgttggttcacaactatcaaINStgagttcatctaaagcaagc																										TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:153259045_153259046insTGAGT	uc003ims.2	-	5	918_919	c.769_770insACTCA	c.(769-771)ATTfs	p.I257fs	FBXW7_uc011cii.1_Frame_Shift_Ins_p.I257fs|FBXW7_uc003imt.2_Frame_Shift_Ins_p.I257fs|FBXW7_uc011cih.1_Frame_Shift_Ins_p.I81fs|FBXW7_uc003imq.2_Frame_Shift_Ins_p.I177fs|FBXW7_uc003imr.2_Frame_Shift_Ins_p.I139fs	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	257					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACAACTATCAATGAGTTCATCT	0.356			Mis|N|D|F		colorectal|endometrial|T-ALL								---	---	---								TGAGT	153259046	TGAGT	TGAGT	153259045	7	5	148	1	0	1	1	0	0	0	0	0	5801	101	4	0	1385	0	FBXW7	4	153259045	Frame_Shift_Ins	INS	-	TCGA-CR-7379-01A-11D-2012-08	11819	153259045	37895231	33	27091											
ACCN5	51802	broad.mit.edu	37	chr4	156752996	156752996	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtaactcagacacactcAccgccttttgctgctgggtt	9	11	8	13	1	2	1	2	0	0	1	2	1	2	1	2	1	3	4	2	1	2	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:156752996A>T	uc003ipe.1	-	9	1354	c.1307T>A	c.(1306-1308)GTG>GAG	p.V436E		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	436	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		AGACACACTCACCGCCTTTTG	0.249													17	73					0	0	0	0	T	156752996	T	T	156752996	3	4	148	1	0	0	0	0	1	0	0	0	132	159	6	5	218	5	ACCN5	4	156752996	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	3493951	156752996	34401280	34	27092											
WDR17	116966	broad.mit.edu	37	chr4	177081214	177081214	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcatagccattggtgatgtGaaaaagctagtccatttttt	11	15	9	6	0	0	2	0	2	0	0	1	2	1	2	2	1	3	2	2	1	4	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:177081214G>A	uc003iuj.2	+	20	2823	c.2667G>A	c.(2665-2667)GTG>GTA	p.V889V	WDR17_uc003iuk.2_Silent_p.V865V|WDR17_uc003ium.3_Silent_p.V865V|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Silent_p.V108V	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	889										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TTGGTGATGTGAAAAAGCTAG	0.378													8	32					0	0	0	0	A	177081214	A	A	177081214	2	1	148	1	0	0	0	0	0	0	0	1	17345	1277	45	2		2	WDR17	4	177081214	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	20328218	177081214	14073062	35	27093											
FAT1	2195	broad.mit.edu	37	chr4	187628208	187628208	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattaggtggaataaatgtaGgtgggttgtcattaacatct	13	14	11	3	0	2	0	1	0	1	0	2	1	2	1	0	4	1	2	0	4	7	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr4:187628208G>C	uc003izf.2	-	2	2962	c.2774C>G	c.(2773-2775)CCT>CGT	p.P925R	FAT1_uc010iso.1_Missense_Mutation_p.P925R	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	925	Extracellular (Potential).|Cadherin 7.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AATAAATGTAGGTGGGTTGTC	0.458										HNSCC(5;0.00058)			38	249					0	0	0	0	C	187628208	C	C	187628208	3	2	148	1	0	0	0	0	1	0	0	0	5721	1000	35	4	11096	4	FAT1	4	187628208	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	10546994	187628208	3526068	36	27094											
CCT5	22948	broad.mit.edu	37	chr5	10250043	10250047	+	5'Flank	DEL	AAAAC	-	-																															aaaaaaaaaaaaaaaaaaaaAaaaccggaaatgggtcctac																								rs140525101	by1000genomes	TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:10250043_10250047delAAAAC	uc003jeq.2	+						FAM173B_uc003jeo.2_5'Flank|FAM173B_uc003jep.2_5'Flank|FAM173B_uc010itr.2_5'Flank|CCT5_uc011cmq.1_5'Flank|CCT5_uc003jer.2_5'Flank|CCT5_uc010its.2_5'Flank|CCT5_uc011cmr.1_5'Flank|CCT5_uc011cms.1_5'Flank|CCT5_uc011cmt.1_5'Flank	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)						'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						aaaaaaaaaaaaaaCCGGAAATGGG	0.424													---	---	---								-	10250047	-	-	10250043	6	5	148	0	1	1	0	1	0	0	0	0	2971	29	1	0		0	CCT5	5	10250043	5'Flank	DEL	AAAAC	TCGA-CR-7379-01A-11D-2012-08		10250043	170665217	37	27095											
PRDM9	56979	broad.mit.edu	37	chr5	23522511	23522511	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccgcaggatgatgattacCtctgtaagtgacacttttgg	10	12	11	8	1	1	3	0	3	1	0	1	4	1	4	2	2	2	2	2	2	2	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:23522511C>A	uc003jgo.2	+	7	789	c.607C>A	c.(607-609)CTC>ATC	p.L203I		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	203					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TGATGATTACCTCTGTAAGTG	0.438										HNSCC(3;0.000094)			32	110					9.65963e-10	2.48534e-09	1	0	A	23522511	A	A	23522511	3	1	148	1	0	0	0	0	1	0	0	0	12525	681	24	4	629	4	PRDM9	5	23522511	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	13272468	23522511	157392749	38	27096											
OTP	23440	broad.mit.edu	37	chr5	76932942	76932942	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagagtggctccctccactgGgtcagagttgggcgccaggt	6	8	15	12	1	1	2	1	0	0	2	3	2	3	2	3	4	0	2	3	4	0	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:76932942G>A	uc003kfg.2	-	2	299	c.151C>T	c.(151-153)CCA>TCA	p.P51S		NM_032109	NP_115485	Q5XKR4	OTP_HUMAN	orthopedia homeobox	51						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;9.04e-51)|Epithelial(54;1.62e-45)|all cancers(79;4.4e-41)		CCCTCCACTGGGTCAGAGTTG	0.716													8	9					0	0	0	0	A	76932942	A	A	76932942	3	1	148	1	0	0	0	0	1	0	0	0	11364	1232	43	4	834	4	OTP	5	76932942	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	53410431	76932942	103982318	39	27097											
PCDHB8	56128	broad.mit.edu	37	chr5	140558802	140558802	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacccttcctcctgaaatCttctgtggggaacttttaca	8	15	6	12	0	3	1	0	1	3	0	5	2	5	2	3	2	3	0	3	2	4	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:140558802C>A	uc011dai.1	+	1	1373	c.1187C>A	c.(1186-1188)TCT>TAT	p.S396Y	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	396	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCTGAAATCTTCTGTGGGG	0.453													34	447					2.81731e-10	7.32502e-10	1	0	A	140558802	A	A	140558802	3	1	148	1	0	0	0	0	1	0	0	0	11602	913	32	2	1189	2	PCDHB8	5	140558802	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	63625860	140558802	40356458	40	27098											
ITK	3702	broad.mit.edu	37	chr5	156668657	156668657	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcttttcaatcaacccaggCctggtgactcgactccggta	8	10	10	13	2	2	1	2	1	0	0	4	2	3	1	3	4	1	2	3	4	3	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:156668657C>T	uc003lwo.1	+	11	1069	c.987C>T	c.(985-987)GGC>GGT	p.G329G		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	329	SH2.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCAACCCAGGCCTGGTGACTC	0.448			T	SYK	peripheral T-cell lymphoma								9	24					0	0	0	0	T	156668657	T	T	156668657	2	4	148	1	0	0	0	0	0	0	0	1	7948	753	26	4		4	ITK	5	156668657	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	16109855	156668657	24246603	41	27099											
GFPT2	9945	broad.mit.edu	37	chr5	179740899	179740899	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcccacggtgttggtgaCgcccacggtgagagcgccgc	5	6	16	14	5	0	2	0	2	0	1	0	3	0	2	3	3	2	2	3	3	0	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr5:179740899C>T	uc003mlw.1	-	14	1437	c.1339G>A	c.(1339-1341)GTC>ATC	p.V447I		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	447	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	GTGTTGGTGACGCCCACGGTG	0.706													4	14					0	0	0	0	T	179740899	T	T	179740899	3	4	148	1	0	0	0	0	1	0	0	0	6383	536	19	1	733	1	GFPT2	5	179740899	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	23072242	179740899	1174361	42	27100											
SERPINB9	5272	broad.mit.edu	37	chr6	2900802	2900802	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttgacacagtatctttaaaAggcgtatggcaaaagtacca	15	10	8	8	1	1	1	0	1	1	0	1	1	1	1	1	2	1	4	1	2	7	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr6:2900802A>G	uc003mug.2	-	2	165	c.44T>C	c.(43-45)CTT>CCT	p.L15P	uc003mue.2_RNA|SERPINB9_uc003muh.2_Missense_Mutation_p.L15P	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	15					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TATCTTTAAAAGGCGTATGGC	0.473													3	162					0	0	0	0	G	2900802	G	G	2900802	3	3	148	1	0	0	0	0	1	0	0	0	14173	72	3	5	1110	5	SERPINB9	6	2900802	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08		2900802	168214265	43	27101											
LRFN2	57497	broad.mit.edu	37	chr6	40399668	40399668	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagccagtgatgtctgagagGcgggacttggggggtgcagt	7	8	20	6	1	1	2	0	2	1	1	1	5	1	3	1	5	2	1	1	5	0	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr6:40399668G>A	uc003oph.1	-	2	1650	c.1185C>T	c.(1183-1185)CGC>CGT	p.R395R		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	395	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGTCTGAGAGGCGGGACTTGG	0.667													14	43					0	0	0	0	A	40399668	A	A	40399668	2	1	148	1	0	0	0	0	0	0	0	1	8988	1190	42	4		4	LRFN2	6	40399668	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	37498866	40399668	130715399	44	27102											
PHF3	23469	broad.mit.edu	37	chr6	64422707	64422707	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagcaaaacccttacaggaGgatattttaatgcaaaatat	18	10	6	7	0	0	0	0	0	0	0	0	2	0	2	1	2	4	2	1	2	9	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr6:64422707G>A	uc003pep.1	+	15	5249	c.5223G>A	c.(5221-5223)GAG>GAA	p.E1741E	PHF3_uc003pen.2_Silent_p.E1653E|PHF3_uc011dxs.1_Silent_p.E1010E	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1741					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CCTTACAGGAGGATATTTTAA	0.388													10	41					0	0	0	0	A	64422707	A	A	64422707	2	1	148	1	0	0	0	0	0	0	0	1	11891	991	35	4		4	PHF3	6	64422707	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	24023039	64422707	106692360	45	27103											
MED23	9439	broad.mit.edu	37	chr6	131917269	131917269	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaggatccacctgttccGcgaggccctcaaaatacaac	12	6	9	14	2	1	0	1	0	0	0	3	3	3	2	4	3	2	1	4	3	4	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr6:131917269G>A	uc003qcs.1	-	22	2987	c.2813C>T	c.(2812-2814)GCG>GTG	p.A938V	MED23_uc003qcq.2_Missense_Mutation_p.A944V|MED23_uc003qcr.1_5'Flank|MED23_uc011eca.1_Missense_Mutation_p.A579V	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	938					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		CACCTGTTCCGCGAGGCCCTC	0.383													25	70					0	0	0	0	A	131917269	A	A	131917269	3	1	148	1	0	0	0	0	1	0	0	0	9494	1087	38	1	1332	1	MED23	6	131917269	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	67494562	131917269	39197798	46	27104											
AHR	196	broad.mit.edu	37	chr7	17349613	17349613	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatccttccaagcggcataGagaccgacttaatacagagt	15	8	8	10	2	0	2	0	0	0	2	2	4	2	2	3	1	2	1	3	1	5	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:17349613G>C	uc011jxz.1	+	2	732	c.119G>C	c.(118-120)AGA>ACA	p.R40T	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	40	Basic motif.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					AAGCGGCATAGAGACCGACTT	0.383													8	38					0	0	0	0	C	17349613	C	C	17349613	3	2	148	1	0	0	0	0	1	0	0	0	416	942	33	2	125	2	AHR	7	17349613	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08		17349613	141789050	47	27105											
MACC1	346389	broad.mit.edu	37	chr7	20199733	20199733	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctcttcctgttatttcttAgttgagttatgtcatccaaa	8	20	5	8	0	3	1	1	1	2	0	6	1	5	1	2	0	0	3	2	0	4	7			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:20199733A>G	uc003sus.3	-	5	560	c.251T>C	c.(250-252)CTA>CCA	p.L84P	MACC1_uc010kug.2_Missense_Mutation_p.L84P	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	84					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						GTTATTTCTTAGTTGAGTTAT	0.348													16	37					0	0	0	0	G	20199733	G	G	20199733	3	3	148	1	0	0	0	0	1	0	0	0	9194	420	15	5	2319	5	MACC1	7	20199733	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	2850120	20199733	138938930	48	27106											
NEUROD6	63974	broad.mit.edu	37	chr7	31378780	31378780	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatctgtttggaaaagctttCtggcttcttaatttgcttct	8	19	7	7	0	4	0	0	0	4	0	4	1	4	1	0	2	2	4	0	2	4	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:31378780C>G	uc003tch.2	-	2	456	c.103G>C	c.(103-105)GAA>CAA	p.E35Q		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	35					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						GAAAAGCTTTCTGGCTTCTTA	0.333													37	121					0	0	0	0	G	31378780	G	G	31378780	3	3	148	1	0	0	0	0	1	0	0	0	10405	922	32	2	914	2	NEUROD6	7	31378780	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	11179047	31378780	127759883	49	27107											
ABCA13	154664	broad.mit.edu	37	chr7	48390266	48390266	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggatgagatgtttaacCatgcaggcgctggacgcttc	8	11	13	9	2	0	1	0	1	0	1	1	4	0	3	1	3	3	5	1	3	1	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:48390266C>T	uc003toq.2	+	30	10256	c.10231C>T	c.(10231-10233)CAT>TAT	p.H3411Y	ABCA13_uc010kys.1_Missense_Mutation_p.H485Y|ABCA13_uc003tos.1_Missense_Mutation_p.H237Y	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3411					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GATGTTTAACCATGCAGGCGC	0.512													63	103					0	0	0	0	T	48390266	T	T	48390266	3	4	148	1	0	0	0	0	1	0	0	0	31	594	21	4	10178	4	ABCA13	7	48390266	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	17011486	48390266	110748397	50	27108											
ZPBP	11055	broad.mit.edu	37	chr7	50121443	50121443	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagcatttcgcagttgttgCgttacacataacacgtgtgg	9	13	10	9	3	1	0	1	0	0	0	2	0	1	0	0	1	4	5	0	1	2	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:50121443C>G	uc003tou.2	-	3	331	c.261G>C	c.(259-261)ACG>ACC	p.T87T	ZPBP_uc011kci.1_Silent_p.T13T|ZPBP_uc010kyw.2_Silent_p.T87T	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	87					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					GCAGTTGTTGCGTTACACATA	0.343													23	39					0	0	0	0	G	50121443	G	G	50121443	2	3	148	1	0	0	0	0	0	0	0	1	18286	755	27	3		3	ZPBP	7	50121443	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	1731177	50121443	109017220	51	27109											
CTTNBP2	83992	broad.mit.edu	37	chr7	117432010	117432010	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagttctgaggagctatgcCtggtgtttgagcggtgggag	6	11	18	6	2	1	2	0	2	1	0	1	5	1	4	1	4	3	3	1	4	1	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:117432010C>T	uc003vjf.2	-	4	1332	c.1240G>A	c.(1240-1242)GGC>AGC	p.G414S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	414	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GGAGCTATGCCTGGTGTTTGA	0.527													4	142					0	0	0	0	T	117432010	T	T	117432010	3	4	148	1	0	0	0	0	1	0	0	0	4062	681	24	4	3831	4	CTTNBP2	7	117432010	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	67310567	117432010	41706653	52	27110											
FAM115C	285966	broad.mit.edu	37	chr7	143417084	143417084	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaaatctaaaagatctgtGtcctctcctatcggagcatg	12	11	7	11	1	3	1	0	0	3	1	6	2	4	2	2	1	1	1	2	1	4	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr7:143417084G>T	uc003wdf.2	+	3	1015	c.932G>T	c.(931-933)TGT>TTT	p.C311F	FAM115C_uc003wdg.2_Missense_Mutation_p.C30F|FAM115C_uc011ktk.1_Missense_Mutation_p.C311F|FAM115C_uc003wdh.2_Missense_Mutation_p.C311F|FAM115C_uc011ktm.1_Missense_Mutation_p.C311F|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron|FAM115C_uc011ktt.1_Missense_Mutation_p.C147F|FAM115C_uc003wdi.1_Missense_Mutation_p.C30F	NM_001130025	NP_001123497	A6NFQ2	F115C_HUMAN	hypothetical protein LOC285966 isoform A	311											0						AAAGATCTGTGTCCTCTCCTA	0.562													6	19					1.58986e-06	3.90743e-06	1	0	T	143417084	T	T	143417084	3	4	148	1	0	0	0	0	1	0	0	0	5434	1377	48	4	1073	4	FAM115C	7	143417084	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	25985074	143417084	15721579	53	27111											
SNTG1	54212	broad.mit.edu	37	chr8	51571204	51571204	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacattctcagtttatgagaTtatgtgcaagatcctcaagg	13	13	8	7	0	2	2	2	1	1	2	4	3	3	2	1	1	2	2	1	1	5	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:51571204T>C	uc010lxy.1	+	16	1390	c.1019T>C	c.(1018-1020)ATT>ACT	p.I340T	SNTG1_uc003xqs.1_Missense_Mutation_p.I340T|SNTG1_uc010lxz.1_Missense_Mutation_p.I340T|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	340	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GTTTATGAGATTATGTGCAAG	0.358													26	30					0	0	0	0	C	51571204	C	C	51571204	3	2	148	1	0	0	0	0	1	0	0	0	14938	1493	52	5	1069	5	SNTG1	8	51571204	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08		51571204	94792818	54	27112											
SULF1	23213	broad.mit.edu	37	chr8	70476367	70476367	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttgtgcttaccgatgatCaagatgtggagctgggtgag	8	13	14	6	1	2	3	1	2	1	1	2	5	2	4	1	2	3	2	1	2	2	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:70476367C>T	uc010lza.1	+	5	874	c.157C>T	c.(157-159)CAA>TAA	p.Q53*	SULF1_uc003xyd.2_Nonsense_Mutation_p.Q53*|SULF1_uc003xye.2_Nonsense_Mutation_p.Q53*|SULF1_uc003xyf.2_Nonsense_Mutation_p.Q53*|SULF1_uc003xyg.2_Nonsense_Mutation_p.Q53*	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	53					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TACCGATGATCAAGATGTGGA	0.468													26	108					0	0	0	0	T	70476367	T	T	70476367	4	4	148	1	0	0	0	0	0	1	0	0	15436	827	29	2	159	2	SULF1	8	70476367	Nonsense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	18905163	70476367	75887655	55	27113											
TRAM1	23471	broad.mit.edu	37	chr8	71520380	71520380	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccgcgtgattctgcaggaCgaattcgtggctcagcactg	7	10	13	11	4	2	1	1	1	1	0	4	3	3	2	1	2	2	3	1	2	1	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:71520380C>T	uc003xyo.1	-	1	225	c.55G>A	c.(55-57)GTC>ATC	p.V19I	TRAM1_uc011lfc.1_Intron	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	19	Cytoplasmic (Potential).				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			TTCTGCAGGACGAATTCGTGG	0.662													24	103					0	0	0	0	T	71520380	T	T	71520380	3	4	148	1	0	0	0	0	1	0	0	0	16518	536	19	1	1113	1	TRAM1	8	71520380	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	1044013	71520380	74843642	56	27114											
ZBTB10	65986	broad.mit.edu	37	chr8	81400004	81400004	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccgagcacaaactccacgAagccaacgcccaggtacagt	14	4	8	15	3	0	0	0	0	0	0	1	2	1	0	4	1	6	2	4	1	5	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:81400004A>G	uc003ybx.3	+	1	1557	c.959A>G	c.(958-960)GAA>GGA	p.E320G	ZBTB10_uc003ybv.3_Intron|ZBTB10_uc003ybw.3_Missense_Mutation_p.E320G|ZBTB10_uc010lzt.2_Missense_Mutation_p.E320G	NM_001105539	NP_001099009	Q96DT7	ZBT10_HUMAN	zinc finger and BTB domain containing 10 isoform	320					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)	1	all_cancers(3;1.68e-09)|all_epithelial(4;5.13e-11)|Lung NSC(7;1.75e-07)|all_lung(9;7.38e-07)|Breast(3;2.96e-06)		BRCA - Breast invasive adenocarcinoma(6;0.000434)|Epithelial(68;0.00486)|all cancers(69;0.0296)			AAACTCCACGAAGCCAACGCC	0.537													6	102					0	0	0	0	G	81400004	G	G	81400004	3	3	148	1	0	0	0	0	1	0	0	0	17590	246	9	5	961	5	ZBTB10	8	81400004	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	9879624	81400004	64964018	57	27115											
NECAB1	64168	broad.mit.edu	37	chr8	91929759	91929759	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttggaacaattcgtaactAgatttttattgaaggaaacc	15	14	7	5	1	0	2	0	1	0	1	1	4	0	4	1	2	3	1	1	2	7	8			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:91929759A>T	uc011lgg.1	+	6	591	c.397A>T	c.(397-399)AGA>TGA	p.R133*		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	133					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			ATTCGTAACTAGATTTTTATT	0.403													14	28					0	0	0	0	T	91929759	T	T	91929759	4	4	148	1	0	0	0	0	0	1	0	0	10358	412	15	5	419	5	NECAB1	8	91929759	Nonsense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	10529755	91929759	54434263	58	27116			1	40		2	2	13	A		6.667158e-05
NECAB1	64168	broad.mit.edu	37	chr8	91929771	91929771	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtaactagatttttattgAaggaaaccctgaatcagctg	13	13	8	7	1	1	3	1	2	0	1	2	4	1	4	1	1	3	2	1	1	6	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:91929771A>T	uc011lgg.1	+	6	603	c.409A>T	c.(409-411)AAG>TAG	p.K137*		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	137	Potential.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			ATTTTTATTGAAGGAAACCCT	0.393													16	30					0	0	0	0	T	91929771	T	T	91929771	4	4	148	1	0	0	0	0	0	1	0	0	10358	247	9	5	431	5	NECAB1	8	91929771	Nonsense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	12	91929771	54434251	59	27117			1	40		2	2	13	A		6.667158e-05
INTS8	55656	broad.mit.edu	37	chr8	95862216	95862216	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgagcttttcattacattGttgaaagatgaagaacgaaa	16	12	8	5	1	1	5	1	3	0	2	1	6	1	5	0	0	3	2	0	0	5	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:95862216G>C	uc003yhb.2	+	12	1530	c.1404G>C	c.(1402-1404)TTG>TTC	p.L468F	INTS8_uc003yha.1_Missense_Mutation_p.L468F|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.L295F	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	468					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TCATTACATTGTTGAAAGATG	0.353													8	76					0	0	0	0	C	95862216	C	C	95862216	3	2	148	1	0	0	0	0	1	0	0	0	7823	1368	48	4	1450	4	INTS8	8	95862216	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	3932445	95862216	50501806	60	27118											
CYP11B2	1585	broad.mit.edu	37	chr8	143999224	143999224	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggacagccagggcgctgcCacgcacacctctgcctttgc	7	6	12	16	2	1	0	0	0	1	0	1	1	1	1	4	2	4	2	4	2	0	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:143999224C>T	uc003yxk.1	-	1	36	c.33G>A	c.(31-33)GTG>GTA	p.V11V		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	11					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	AGGGCGCTGCCACGCACACCT	0.617									Familial_Hyperaldosteronism_type_I				41	180					0	0	0	0	T	143999224	T	T	143999224	2	4	148	1	0	0	0	0	0	0	0	1	4163	581	21	4		4	CYP11B2	8	143999224	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	48137008	143999224	2364798	61	27119											
FAM83H	286077	broad.mit.edu	37	chr8	144811234	144811234	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtgcggcagtagtaggtggGgcccgccacagtccgtacgc	7	6	16	12	4	0	0	0	0	0	0	1	0	1	0	3	4	2	4	3	4	3	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:144811234G>T	uc003yzk.2	-	4	709	c.640C>A	c.(640-642)CCC>ACC	p.P214T	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	214					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TAGTAGGTGGGGCCCGCCACA	0.627													31	112					3.90053e-15	1.03041e-14	1	0	T	144811234	T	T	144811234	3	4	148	1	0	0	0	0	1	0	0	0	5672	1232	43	4	2907	4	FAM83H	8	144811234	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	812010	144811234	1552788	62	27120											
PLEC	5339	broad.mit.edu	37	chr8	145012832	145012832	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgttgacccacttggtgaaGgttttcttctgcacacgatc	7	15	9	10	1	2	2	0	2	2	0	3	3	2	2	1	2	1	3	1	2	1	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr8:145012832G>T	uc003zaf.1	-	2	722	c.552C>A	c.(550-552)ACC>ACA	p.T184T	PLEC_uc003zab.1_Silent_p.T47T|PLEC_uc003zac.1_Silent_p.T51T|PLEC_uc003zad.2_Silent_p.T47T|PLEC_uc003zae.1_Silent_p.T15T|PLEC_uc003zag.1_Silent_p.T25T|PLEC_uc003zah.2_Silent_p.T33T|PLEC_uc003zaj.2_Silent_p.T74T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	184	CH 1.|Globular 1.|Actin-binding.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						ACTTGGTGAAGGTTTTCTTCT	0.637													17	85					6.94344e-10	1.79584e-09	1	0	T	145012832	T	T	145012832	2	4	148	1	0	0	0	0	0	0	0	1	12107	987	35	4		4	PLEC	8	145012832	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	201598	145012832	1351190	63	27121											
TPD52L3	89882	broad.mit.edu	37	chr9	6328941	6328941	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttggaggcgtgaagaagtcgGccacattcagatcttttgaa	11	11	12	7	2	2	4	1	2	1	2	3	5	2	5	1	3	0	0	1	3	3	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:6328941G>A	uc003zjw.2	+	1	567	c.346G>A	c.(346-348)GCC>ACC	p.A116T	TPD52L3_uc003zjv.2_Missense_Mutation_p.A116T|TPD52L3_uc003zjx.1_Missense_Mutation_p.A116T	NM_033516	NP_277051	Q96J77	TPD55_HUMAN	protein kinase NYD-SP25 isoform 1	116							protein binding				0		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		GAAGAAGTCGGCCACATTCAG	0.517													12	74					0	0	0	0	A	6328941	A	A	6328941	3	1	148	1	0	0	0	0	1	0	0	0	16467	1203	42	4	348	4	TPD52L3	9	6328941	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08		6328941	134884490	64	27122											
TTC39B	158219	broad.mit.edu	37	chr9	15199906	15199906	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgagtccacctttgatgaaGttgatcatattttcatcctg	9	17	7	8	0	2	4	2	4	0	0	4	4	4	4	3	0	0	1	3	0	2	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:15199906G>A	uc003zlr.1	-	8	700	c.579C>T	c.(577-579)AAC>AAT	p.N193N	TTC39B_uc003zlq.1_Silent_p.N162N|TTC39B_uc011lmp.1_Silent_p.N94N|TTC39B_uc010mie.1_Silent_p.N191N|TTC39B_uc011lmq.1_Silent_p.N193N|TTC39B_uc011lmr.1_Silent_p.N124N|TTC39B_uc010mif.1_Silent_p.N193N|TTC39B_uc003zls.1_Silent_p.N94N|TTC39B_uc010mig.1_Silent_p.N162N|TTC39B_uc011lms.1_Intron	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	193							binding			ovary(1)	1						CTTTGATGAAGTTGATCATAT	0.274													4	22					0	0	0	0	A	15199906	A	A	15199906	2	1	148	1	0	0	0	0	0	0	0	1	16776	1020	36	4		4	TTC39B	9	15199906	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	8870965	15199906	126013525	65	27123											
ACO1	48	broad.mit.edu	37	chr9	32407405	32407405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagtgccatttaagcctgctCgtgtcatcctgcaggacttt	8	13	9	11	1	1	0	1	0	0	0	3	1	2	1	3	1	4	2	3	1	2	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:32407405C>T	uc003zqw.3	+	3	399	c.244C>T	c.(244-246)CGT>TGT	p.R82C	ACO1_uc010mjh.1_5'UTR|ACO1_uc003zqx.3_Missense_Mutation_p.R82C|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	82					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TAAGCCTGCTCGTGTCATCCT	0.388													9	44					0	0	0	0	T	32407405	T	T	32407405	3	4	148	1	0	0	0	0	1	0	0	0	146	884	31	1	250	1	ACO1	9	32407405	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	17207499	32407405	108806026	66	27124											
CCDC107	203260	broad.mit.edu	37	chr9	35658694	35658694	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcgctgtacaccgcggccgtCgcggcttttgtgctgtacaa	5	10	13	13	6	0	0	0	0	0	0	1	0	0	0	2	2	3	5	2	2	3	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:35658694C>G	uc011lox.1	+	2	294	c.228C>G	c.(226-228)GTC>GTG	p.V76V	RMRP_uc003zxh.1_5'Flank|CCDC107_uc010mkx.1_Silent_p.V76V|CCDC107_uc011loy.1_Silent_p.V76V|CCDC107_uc003zxj.2_Silent_p.V76V|CCDC107_uc003zxk.2_Silent_p.V76V	NM_174923	NP_777583	Q8WV48	CC107_HUMAN	coiled-coil domain containing 107 precursor	76	Helical; (Potential).					integral to membrane					0	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CCGCGGCCGTCGCGGCTTTTG	0.731													11	32					0	0	0	0	G	35658694	G	G	35658694	2	3	148	1	0	0	0	0	0	0	0	1	2754	871	31	3		3	CCDC107	9	35658694	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	3251289	35658694	105554737	67	27125											
PGM5	5239	broad.mit.edu	37	chr9	71098810	71098810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggggttggatcccaagaCgacatattatatcatgaggg	12	10	13	6	1	1	3	1	2	0	1	2	5	2	4	1	4	0	1	1	4	4	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:71098810C>T	uc004agr.2	+	9	1554	c.1325C>T	c.(1324-1326)ACG>ATG	p.T442M		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	442					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						GATCCCAAGACGACATATTAT	0.512													15	51					0	0	0	0	T	71098810	T	T	71098810	3	4	148	1	0	0	0	0	1	0	0	0	11856	536	19	1	1359	1	PGM5	9	71098810	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	35440116	71098810	70114621	68	27126											
SHC3	53358	broad.mit.edu	37	chr9	91657049	91657049	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaggtgggtgcttctcccgTgggggccacgtgcagtttcc	3	11	16	11	2	1	0	0	0	1	0	3	0	2	0	3	4	2	4	3	4	1	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:91657049T>C	uc004aqg.2	-	10	1559	c.1252A>G	c.(1252-1254)ACG>GCG	p.T418A		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	418	CH1.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						GCTTCTCCCGTGGGGGCCACG	0.572													35	102					0	0	0	0	C	91657049	C	C	91657049	3	2	148	1	0	0	0	0	1	0	0	0	14337	1696	59	5	544	5	SHC3	9	91657049	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	20558239	91657049	49556382	69	27127											
SPTAN1	6709	broad.mit.edu	37	chr9	131367378	131367378	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tctaaacacagacaattatgGacatgatctcgccagtgtcc	13	10	7	11	1	2	2	0	1	2	1	4	3	3	3	2	1	1	0	2	1	4	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:131367378G>C	uc004bvl.3	+	30	3898	c.3785G>C	c.(3784-3786)GGA>GCA	p.G1262A	SPTAN1_uc011mbh.1_Missense_Mutation_p.G1274A|SPTAN1_uc004bvm.3_Missense_Mutation_p.G1262A|SPTAN1_uc004bvn.3_Missense_Mutation_p.G1242A	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1262	Spectrin 14.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GACAATTATGGACATGATCTC	0.488													5	42					0	0	0	0	C	131367378	C	C	131367378	3	2	148	1	0	0	0	0	1	0	0	0	15183	1174	41	2	3899	2	SPTAN1	9	131367378	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	39710329	131367378	9846053	70	27128											
NOTCH1	4851	broad.mit.edu	37	chr9	139396213	139396213	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttaccaggcccgcggacAttgacgtccatgcagtcggc	7	7	11	16	4	0	1	0	1	0	0	2	2	1	2	4	3	2	1	4	3	1	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr9:139396213A>T	uc004chz.2	-	30	5625	c.5625T>A	c.(5623-5625)AAT>AAA	p.N1875K		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1875	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCCCGCGGACATTGACGTCCA	0.662			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			7	29					0	0	0	0	T	139396213	T	T	139396213	3	4	148	1	0	0	0	0	1	0	0	0	10601	214	8	5	2062	5	NOTCH1	9	139396213	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	8028835	139396213	1817218	71	27129											
FAM171A1	221061	broad.mit.edu	37	chr10	15255111	15255111	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaggctgggcagctggcCaccacttctccgactcgacc	6	7	11	17	2	1	0	0	0	1	0	3	2	1	0	4	3	2	4	4	3	0	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:15255111C>T	uc001iob.2	-	8	2483	c.2476G>A	c.(2476-2478)GGC>AGC	p.G826S		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	826	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						GGCAGCTGGCCACCACTTCTC	0.647													14	68					0	0	0	0	T	15255111	T	T	15255111	3	4	148	1	0	0	0	0	1	0	0	0	5518	594	21	4	200	4	FAM171A1	10	15255111	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08		15255111	120279636	72	27130											
RBP3	5949	broad.mit.edu	37	chr10	48388751	48388751	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgggggtgcttcctctacCaccagctcgccagggctgtg	4	9	15	13	1	1	0	0	0	1	0	3	0	2	0	4	4	3	3	4	4	1	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:48388751C>T	uc001jez.2	-	1	2241	c.2127G>A	c.(2125-2127)GTG>GTA	p.V709V		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	709	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CTTCCTCTACCACCAGCTCGC	0.627													15	51					0	0	0	0	T	48388751	T	T	48388751	2	4	148	1	0	0	0	0	0	0	0	1	13222	581	21	4		4	RBP3	10	48388751	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	33133640	48388751	87145996	73	27131											
C10orf12	26148	broad.mit.edu	37	chr10	98743187	98743187	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacagcatgtggaggaggcTgtgaatgaggtagacaacga	14	6	15	6	1	0	3	0	2	0	1	0	6	0	5	0	4	2	3	0	4	3	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:98743187T>A	uc001kmv.2	+	1	2147	c.2040T>A	c.(2038-2040)GCT>GCA	p.A680A		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	680										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGGAGGAGGCTGTGAATGAGG	0.498													12	58					0	0	0	0	A	98743187	A	A	98743187	2	1	148	1	0	0	0	0	0	0	0	1	1595	1567	55	5		5	C10orf12	10	98743187	Silent	SNP	T	TCGA-CR-7379-01A-11D-2012-08	50354436	98743187	36791560	74	27132											
C10orf12	26148	broad.mit.edu	37	chr10	98744511	98744511	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgatggagccaccaaaaccCctgctgccaagaggccagct	11	5	10	15	0	0	2	0	1	0	1	0	3	0	3	6	2	5	2	6	2	3	0			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:98744511C>T	uc001kmv.2	+	1	3471	c.3364C>T	c.(3364-3366)CCT>TCT	p.P1122S		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	1122										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CACCAAAACCCCTGCTGCCAA	0.517													10	62					0	0	0	0	T	98744511	T	T	98744511	3	4	148	1	0	0	0	0	1	0	0	0	1595	623	22	4	3366	4	C10orf12	10	98744511	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	1324	98744511	36790236	75	27133											
MGEA5	10724	broad.mit.edu	37	chr10	103558656	103558656	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acactactatttgctcgaagCcattgaaattcccgtaacat	13	12	5	11	2	0	1	0	1	0	0	2	2	1	1	2	0	4	2	2	0	5	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:103558656C>T	uc001ktv.2	-	9	2195	c.1752G>A	c.(1750-1752)TGG>TGA	p.W584*	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Nonsense_Mutation_p.W531*|MGEA5_uc009xws.2_Nonsense_Mutation_p.W531*|MGEA5_uc001ktw.2_Nonsense_Mutation_p.W584*|MGEA5_uc009xwt.2_Nonsense_Mutation_p.W347*	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	584	Histone acetyltransferase activity (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TTGCTCGAAGCCATTGAAATT	0.443													11	91					0	0	0	0	T	103558656	T	T	103558656	4	4	148	1	0	0	0	0	0	1	0	0	9608	740	26	4	1030	4	MGEA5	10	103558656	Nonsense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	4814145	103558656	31976091	76	27134											
C10orf78	119392	broad.mit.edu	37	chr10	105882813	105882813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaggcctctgcgaatccatCatctccctatacaaatagtt	11	12	5	13	1	4	0	2	0	2	0	6	1	5	0	3	1	2	1	3	1	5	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:105882813C>T	uc001kxu.2	+	2	117	c.104C>T	c.(103-105)TCA>TTA	p.S35L	C10orf78_uc001kxs.2_Missense_Mutation_p.S22L|C10orf78_uc001kxt.2_5'UTR|C10orf78_uc001kxv.2_Missense_Mutation_p.S97L	NM_001002759	NP_001002759	Q86XK3	SFR1_HUMAN	hypothetical protein LOC119392 isoform a	35					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;1.31e-09)|all cancers(201;3.84e-08)|BRCA - Breast invasive adenocarcinoma(275;0.014)		GCGAATCCATCATCTCCCTAT	0.398													13	105					0	0	0	0	T	105882813	T	T	105882813	3	4	148	1	0	0	0	0	1	0	0	0	1623	838	29	2	110	2	C10orf78	10	105882813	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	2324157	105882813	29651934	77	27135											
SORCS1	114815	broad.mit.edu	37	chr10	108389086	108389086	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccatggagctgagattgaCgtaagacaccgcgataccat	12	9	10	10	3	0	3	0	2	0	2	1	6	1	4	3	1	2	2	3	1	2	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:108389086C>T	uc001kym.2	-	19	2544	c.2536G>A	c.(2536-2538)GTC>ATC	p.V846I	SORCS1_uc001kyl.2_Missense_Mutation_p.V846I|SORCS1_uc009xxs.2_Missense_Mutation_p.V846I|SORCS1_uc001kyn.1_Missense_Mutation_p.V846I|SORCS1_uc001kyo.2_Missense_Mutation_p.V846I	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	846	Lumenal (Potential).|PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTGAGATTGACGTAAGACACC	0.488													8	41					0	0	0	0	T	108389086	T	T	108389086	3	4	148	1	0	0	0	0	1	0	0	0	14994	536	19	1	1236	1	SORCS1	10	108389086	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	2506273	108389086	27145661	78	27136											
FAM160B1	57700	broad.mit.edu	37	chr10	116593011	116593011	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgataaagccccagtgacCgatacaaatattccatcgca	15	8	7	11	2	0	2	0	2	0	0	2	4	1	2	4	0	2	1	4	0	5	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:116593011C>T	uc001lcb.2	+	3	479	c.144C>T	c.(142-144)ACC>ACT	p.T48T	FAM160B1_uc001lcc.2_Silent_p.T48T	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	48										lung(1)	1						CCCCAGTGACCGATACAAATA	0.338													5	45					0	0	0	0	T	116593011	T	T	116593011	2	4	148	1	0	0	0	0	0	0	0	1	5498	639	23	1		1	FAM160B1	10	116593011	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	8203925	116593011	18941736	79	27137											
MKI67	4288	broad.mit.edu	37	chr10	129913712	129913712	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacagactccacgtctctTcccttccccttgttctggtc	5	14	6	16	1	2	2	0	1	2	1	7	2	5	2	4	1	1	1	4	1	1	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr10:129913712T>C	uc001lke.2	-	7	1155	c.960A>G	c.(958-960)GGA>GGG	p.G320G	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	320					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CCACGTCTCTTCCCTTCCCCT	0.547													18	79					0	0	0	0	C	129913712	C	C	129913712	2	2	148	1	0	0	0	0	0	0	0	1	9651	1770	62	5		5	MKI67	10	129913712	Silent	SNP	T	TCGA-CR-7379-01A-11D-2012-08	13320701	129913712	5621035	80	27138											
OR52D1	390066	broad.mit.edu	37	chr11	5509984	5509984	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcttccagacaccttcttCttaacagggatcccagggct	9	11	7	14	0	3	1	0	0	3	1	5	2	5	2	3	2	1	1	3	2	1	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:5509984C>T	uc010qzg.1	+	1	48	c.48C>T	c.(46-48)TTC>TTT	p.F16F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACACCTTCTTCTTAACAGGGA	0.488													18	67					0	0	0	0	T	5509984	T	T	5509984	2	4	148	1	0	0	0	0	0	0	0	1	11168	912	32	2		2	OR52D1	11	5509984	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08		5509984	129496532	81	27139											
HPX	3263	broad.mit.edu	37	chr11	6452483	6452483	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggtcacattctggggttgCggaagggccttggctgcatt	5	12	15	9	1	2	0	1	0	1	0	2	1	2	1	1	6	2	3	1	6	1	4	rs143855789		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:6452483C>T	uc001mdg.2	-	10	1408	c.1347G>A	c.(1345-1347)CCG>CCA	p.P449P	HPX_uc001mdf.2_Silent_p.P195P|HPX_uc009yfc.2_RNA	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	449					cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		TCTGGGGTTGCGGAAGGGCCT	0.542													6	69					0	0	0	0	T	6452483	T	T	6452483	2	4	148	1	0	0	0	0	0	0	0	1	7385	755	27	1		1	HPX	11	6452483	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	942499	6452483	128554033	82	27140											
PRMT3	10196	broad.mit.edu	37	chr11	20409618	20409618	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccagaactgtcggacagcGgggacgaggccgcctgggag	8	4	18	11	4	0	1	0	0	0	1	1	5	0	4	3	5	3	0	3	5	1	0			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:20409618G>A	uc001mqb.2	+	2	299	c.82G>A	c.(82-84)GGG>AGG	p.G28R	PRMT3_uc001mqc.2_Intron|PRMT3_uc010rdn.1_Intron	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1	28							zinc ion binding				0						GTCGGACAGCGGGGACGAGGC	0.647													5	39					0	0	0	0	A	20409618	A	A	20409618	3	1	148	1	0	0	0	0	1	0	0	0	12600	1116	39	1	88	1	PRMT3	11	20409618	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	13957135	20409618	114596898	83	27141											
MADD	8567	broad.mit.edu	37	chr11	47298327	47298327	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgcactctccatgtctgtGatggcattcgtggcaatgat	9	13	10	9	1	2	2	0	2	2	0	4	2	2	2	1	2	1	3	1	2	2	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:47298327G>C	uc001ner.1	+	5	1199	c.1008G>C	c.(1006-1008)GTG>GTC	p.V336V	MADD_uc001neq.2_Silent_p.V336V|MADD_uc001nev.1_Silent_p.V336V|MADD_uc001nes.1_Silent_p.V336V|MADD_uc001net.1_Silent_p.V336V|MADD_uc009yln.1_Silent_p.V336V|MADD_uc001neu.1_Silent_p.V336V|MADD_uc001nex.2_Silent_p.V336V|MADD_uc001nez.2_Silent_p.V336V|MADD_uc001new.2_Silent_p.V336V	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	336	Helical; (Potential).|DENN.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		CCATGTCTGTGATGGCATTCG	0.483													12	87					0	0	0	0	C	47298327	C	C	47298327	2	2	148	1	0	0	0	0	0	0	0	1	9203	1277	45	2		2	MADD	11	47298327	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	26888709	47298327	87708189	84	27142											
OR5AS1	219447	broad.mit.edu	37	chr11	55798090	55798090	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtattattttcttagcaacTtatctttcttagacatcagc	10	19	4	8	0	4	1	1	0	3	1	4	1	4	1	0	0	3	2	0	0	6	8			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:55798090T>G	uc010riw.1	+	1	196	c.196T>G	c.(196-198)TTA>GTA	p.L66V		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					TCTTAGCAACTTATCTTTCTT	0.348													6	43					0	0	0	0	G	55798090	G	G	55798090	3	3	148	1	0	0	0	0	1	0	0	0	11200	1606	56	5	198	5	OR5AS1	11	55798090	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	8499763	55798090	79208426	85	27143											
SLC43A3	29015	broad.mit.edu	37	chr11	57175311	57175311	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccaagtacggcattcccgaTataccagaaaggggtggaag	13	7	12	9	2	0	1	0	0	0	1	2	3	2	2	3	4	2	2	3	4	6	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:57175311T>G	uc001nkg.2	-	14	1840	c.1430A>C	c.(1429-1431)TAT>TCT	p.Y477S	PRG2_uc001nke.2_Intron|SLC43A3_uc001nkh.2_Missense_Mutation_p.Y477S|SLC43A3_uc010rjr.1_Missense_Mutation_p.Y490S|SLC43A3_uc009yme.2_Missense_Mutation_p.Y477S|SLC43A3_uc001nki.2_Missense_Mutation_p.Y477S	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	477					transmembrane transport	integral to membrane				central_nervous_system(1)	1						GCATTCCCGATATACCAGAAA	0.473													3	69					0	0	0	0	G	57175311	G	G	57175311	3	3	148	1	0	0	0	0	1	0	0	0	14698	1406	49	5	49	5	SLC43A3	11	57175311	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	1377221	57175311	77831205	86	27144											
MS4A2	2206	broad.mit.edu	37	chr11	59863040	59863040	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcccttatcaggttccagagGatcgtgtttatgaagaatta	11	14	9	7	1	1	3	1	1	0	2	4	4	3	4	2	2	0	2	2	2	5	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:59863040G>A	uc001nop.2	+	7	748	c.646G>A	c.(646-648)GAT>AAT	p.D216N		NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	216	Cytoplasmic (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	GGTTCCAGAGGATCGTGTTTA	0.388													6	31					0	0	0	0	A	59863040	A	A	59863040	3	1	148	1	0	0	0	0	1	0	0	0	9913	1174	41	2	723	2	MS4A2	11	59863040	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	2687729	59863040	75143476	87	27145											
EXPH5	23086	broad.mit.edu	37	chr11	108380962	108380962	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatttctgtgcaggctccaGtggaaaaggagggctcagcc	10	8	14	9	0	2	1	1	0	1	1	3	3	3	3	2	4	2	3	2	4	2	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr11:108380962G>A	uc001pkk.2	-	6	5383	c.5272C>T	c.(5272-5274)CTG>TTG	p.L1758L	EXPH5_uc010rvy.1_Silent_p.L1570L|EXPH5_uc010rvz.1_Silent_p.L1602L|EXPH5_uc010rwa.1_Silent_p.L1682L	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1758					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GCAGGCTCCAGTGGAAAAGGA	0.512													15	77					0	0	0	0	A	108380962	A	A	108380962	2	1	148	1	0	0	0	0	0	0	0	1	5347	1020	36	4		4	EXPH5	11	108380962	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	48517922	108380962	26625554	88	27146											
PRH2	5555	broad.mit.edu	37	chr12	11082884	11082884	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagatgtcagccaagaagaCgttcccttggtaatatcagg	12	10	10	9	1	2	3	2	0	0	3	3	3	3	3	2	2	1	2	2	2	5	5	rs1130408		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:11082884C>T	uc009zhr.2	+	2	119	c.81C>T	c.(79-81)GAC>GAT	p.D27D	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH2_uc001qzh.2_Silent_p.D27D|PRH2_uc001qzi.3_Silent_p.D27D	NM_001110213	NP_001103683	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 2	27	Inhibits hydroxyapatite formation, binds to hydroxyapatite and calcium.					extracellular space	protein binding				0						GCCAAGAAGACGTTCCCTTGG	0.388													13	76					0	0	0	0	T	11082884	T	T	11082884	2	4	148	1	0	0	0	0	0	0	0	1	12545	535	19	1		1	PRH2	12	11082884	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08		11082884	122769011	89	27147											
PPFIBP1	8496	broad.mit.edu	37	chr12	27841969	27841969	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctagagcctcgttttaacGtagaaacaatggctcagtta	12	13	8	8	2	2	2	1	0	1	2	3	2	2	2	1	1	3	4	1	1	6	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:27841969G>A	uc001ric.1	+	26	2913	c.2536G>A	c.(2536-2538)GTA>ATA	p.V846I	PPFIBP1_uc010sjr.1_Missense_Mutation_p.V677I|PPFIBP1_uc001rib.1_Missense_Mutation_p.V840I|PPFIBP1_uc001ria.2_Missense_Mutation_p.V815I|PPFIBP1_uc001rid.1_Missense_Mutation_p.V693I|PPFIBP1_uc001rif.1_Missense_Mutation_p.V353I	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	846	SAM 3.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					TCGTTTTAACGTAGAAACAAT	0.338													15	72					0	0	0	0	A	27841969	A	A	27841969	3	1	148	1	0	0	0	0	1	0	0	0	12368	1145	40	1	2658	1	PPFIBP1	12	27841969	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	16759085	27841969	106009926	90	27148											
MLL2	8085	broad.mit.edu	37	chr12	49447796	49447796	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctcactgtgctctgggcatAgcagctgcagtgttttcatg	6	13	11	11	0	3	0	2	0	1	0	3	0	3	0	1	1	4	6	1	1	1	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:49447796A>G	uc001rta.3	-	5	638	c.638T>C	c.(637-639)CTA>CCA	p.L213P		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	213					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTCTGGGCATAGCAGCTGCAG	0.532			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			18	69					0	0	0	0	G	49447796	G	G	49447796	3	3	148	1	0	0	0	0	1	0	0	0	9674	420	15	5	16175	5	MLL2	12	49447796	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	21605827	49447796	84404099	91	27149											
CALCOCO1	57658	broad.mit.edu	37	chr12	54110137	54110137	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgctcctcttgccagctCttcgcctccttcaggtccaa	4	13	6	18	1	4	0	1	0	3	0	8	0	7	0	5	1	3	2	5	1	1	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:54110137C>T	uc001sef.2	-	8	1056	c.912G>A	c.(910-912)AAG>AAA	p.K304K	CALCOCO1_uc001see.2_5'Flank|CALCOCO1_uc010som.1_Intron|CALCOCO1_uc010son.1_Silent_p.K181K|CALCOCO1_uc001seh.2_Silent_p.K304K|CALCOCO1_uc009znd.2_Silent_p.K304K|CALCOCO1_uc001seg.2_Intron|CALCOCO1_uc010soo.1_Silent_p.K297K	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	304	Potential.				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CTTGCCAGCTCTTCGCCTCCT	0.562													26	68					0	0	0	0	T	54110137	T	T	54110137	2	4	148	1	0	0	0	0	0	0	0	1	2589	912	32	2		2	CALCOCO1	12	54110137	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	4662341	54110137	79741758	92	27150											
DTX3	196403	broad.mit.edu	37	chr12	58000719	58000719	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgactgtgtccaagcccGtgtgggacttcctgagcaaa	10	9	12	10	1	0	2	0	2	0	0	2	3	2	3	3	1	2	1	3	1	3	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:58000719G>A	uc001sow.1	+	5	410	c.73G>A	c.(73-75)GTG>ATG	p.V25M	DTX3_uc001sov.1_Missense_Mutation_p.V18M|DTX3_uc001sox.1_Missense_Mutation_p.V18M|DTX3_uc001soy.1_Missense_Mutation_p.V18M	NM_178502	NP_848597	Q8N9I9	DTX3_HUMAN	deltex homolog 3	25					Notch signaling pathway	cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					GTCCAAGCCCGTGTGGGACTT	0.597													99	227					0	0	0	0	A	58000719	A	A	58000719	3	1	148	1	0	0	0	0	1	0	0	0	4817	1145	40	1	79	1	DTX3	12	58000719	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	3890582	58000719	75851176	93	27151											
PPFIA2	8499	broad.mit.edu	37	chr12	81675072	81675072	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatttttaaatggacacggAgatctttttttgttaggtga	10	17	9	5	1	1	2	0	1	1	1	1	4	1	3	1	3	0	1	1	3	3	7			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:81675072A>G	uc001szo.1	-	27	3337	c.3176T>C	c.(3175-3177)CTC>CCC	p.L1059P	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	958										ovary(3)|lung(2)|pancreas(1)	6						ATGGACACGGAGATCTTTTTT	0.343													4	26					0	0	0	0	G	81675072	G	G	81675072	3	3	148	1	0	0	0	0	1	0	0	0	12365	304	11	5	621	5	PPFIA2	12	81675072	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	23674353	81675072	52176823	94	27152											
KERA	11081	broad.mit.edu	37	chr12	91449289	91449289	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgatgatacatcaaatcctCttgatgggagaccctcatct	11	13	7	10	0	4	4	2	3	2	1	5	5	5	4	2	1	1	0	2	1	2	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:91449289C>T	uc001tbl.2	-	2	1389	c.770G>A	c.(769-771)AGA>AAA	p.R257K		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	257	LRR 8.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						ATCAAATCCTCTTGATGGGAG	0.398													19	63					0	0	0	0	T	91449289	T	T	91449289	3	4	148	1	0	0	0	0	1	0	0	0	8182	913	32	2	296	2	KERA	12	91449289	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	9774217	91449289	42402606	95	27153											
NAA25	80018	broad.mit.edu	37	chr12	112506764	112506764	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggtttatcgccaaacttttTaaaatactggaacattaatt	15	15	5	6	1	0	0	0	0	0	0	1	1	0	1	1	2	3	1	1	2	7	8	rs149344901		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:112506764T>A	uc001ttm.2	-	11	1089	c.1069A>T	c.(1069-1071)AAA>TAA	p.K357*	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Nonsense_Mutation_p.K329*|NAA25_uc009zwa.1_Nonsense_Mutation_p.K357*	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	357						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						CCAAACTTTTTAAAATACTGG	0.353													13	51					0	0	0	0	A	112506764	A	A	112506764	4	1	148	1	0	0	0	0	0	1	0	0	10174	1763	61	5	1905	5	NAA25	12	112506764	Nonsense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	21057475	112506764	21345131	96	27154											
MED13L	23389	broad.mit.edu	37	chr12	116434432	116434432	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcttcagtggagcaaacaTggaggatcccacaaaaggtt	14	8	10	9	0	2	0	1	0	1	0	3	3	3	3	1	4	2	2	1	4	3	2	rs35760315		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:116434432T>C	uc001tvw.2	-	16	2900	c.2845A>G	c.(2845-2847)ATG>GTG	p.M949V		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	949					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GGAGCAAACATGGAGGATCCC	0.438													10	41					0	0	0	0	C	116434432	C	C	116434432	3	2	148	1	0	0	0	0	1	0	0	0	9484	1464	51	5	3851	5	MED13L	12	116434432	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	3927668	116434432	17417463	97	27155											
KSR2	283455	broad.mit.edu	37	chr12	118406030	118406030	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caaactcagaggctgctgctCctcgcttttcgtcatgtttt	6	15	8	12	2	2	1	2	0	0	1	5	1	3	1	1	1	3	5	1	1	1	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:118406030C>A	uc001two.2	-	1	1	c.-54_splice	c.e1-1			NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2						intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCTGCTGCTCCTCGCTTTTC	0.522													7	110					0.00198382	0.00475731	1	0	A	118406030	A	A	118406030	5	1	148	1	0	0	0	0	0	0	1	0	8622	870	30	2		2	KSR2	12	118406030	Splice_Site	SNP	C	TCGA-CR-7379-01A-11D-2012-08	1971598	118406030	15445865	98	27156											
NCOR2	9612	broad.mit.edu	37	chr12	124862849	124862849	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcctccatctcctcatcctCcaccacgggcgggaatgcag	7	7	9	18	3	2	0	1	0	1	0	6	1	5	1	6	2	1	1	6	2	1	0			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr12:124862849C>A	uc010tba.1	-	18	2218	c.2101G>T	c.(2101-2103)GAG>TAG	p.E701*	NCOR2_uc010tay.1_Nonsense_Mutation_p.E701*|NCOR2_uc010taz.1_Nonsense_Mutation_p.E701*|NCOR2_uc010tbb.1_Nonsense_Mutation_p.E701*|NCOR2_uc010tbc.1_Nonsense_Mutation_p.E700*|NCOR2_uc001ugj.1_Nonsense_Mutation_p.E701*	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	701					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TCCTCATCCTCCACCACGGGC	0.667													14	53					4.3838e-07	1.08824e-06	1	0	A	124862849	A	A	124862849	4	1	148	1	0	0	0	0	0	1	0	0	10290	864	30	2	5587	2	NCOR2	12	124862849	Nonsense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	6456819	124862849	8989046	99	27157											
ATP12A	479	broad.mit.edu	37	chr13	25275010	25275010	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtcaatgatcgatccccctCggtccaccgtgccagatgca	8	9	9	15	3	1	2	1	1	0	1	5	3	3	2	5	1	2	1	5	1	1	0			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr13:25275010C>T	uc001upp.2	+	13	2018	c.1831C>T	c.(1831-1833)CGG>TGG	p.R611W	ATP12A_uc010aaa.2_Missense_Mutation_p.R617W	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	611	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CGATCCCCCTCGGTCCACCGT	0.483													10	48					0	0	0	0	T	25275010	T	T	25275010	3	4	148	1	0	0	0	0	1	0	0	0	1124	875	31	1	1899	1	ATP12A	13	25275010	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08		25275010	89894868	100	27158											
RB1	5925	broad.mit.edu	37	chr13	49027134	49027134	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgtttcatataggattcAcctttatttgatcttattaa	11	20	4	6	0	4	1	3	1	1	0	4	2	4	2	1	1	0	1	1	1	5	9			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr13:49027134A>T	uc001vcb.2	+	18	1867	c.1701A>T	c.(1699-1701)TCA>TCT	p.S567S		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	567	Domain A.|Pocket; binds T and E1A.		S -> L (in RB).		androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)|p.S567*(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TATAGGATTCACCTTTATTTG	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			3	32					0	0	0	0	T	49027134	T	T	49027134	2	4	148	1	0	0	0	0	0	0	0	1	13163	146	6	5		5	RB1	13	49027134	Silent	SNP	A	TCGA-CR-7379-01A-11D-2012-08	23752124	49027134	66142744	101	27159											
CLDN10	9071	broad.mit.edu	37	chr13	96212417	96212417	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcatgtagaggacttatgatCgctgctgtcagcctgggctt	7	12	13	9	1	1	2	1	1	0	1	2	3	1	3	1	2	2	5	1	2	2	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr13:96212417C>G	uc001vmh.2	+	2	313	c.252C>G	c.(250-252)ATC>ATG	p.I84M	CLDN10_uc001vmg.2_Missense_Mutation_p.I82M|CLDN10_uc010tii.1_Missense_Mutation_p.I63M	NM_006984	NP_008915	P78369	CLD10_HUMAN	claudin 10 isoform b	84	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			GACTTATGATCGCTGCTGTCA	0.433													5	64					0	0	0	0	G	96212417	G	G	96212417	3	3	148	1	0	0	0	0	1	0	0	0	3487	874	31	3	476	3	CLDN10	13	96212417	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	47185283	96212417	18957461	102	27160											
POTEG	404785	broad.mit.edu	37	chr14	19566010	19566010	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttattacaattttatacatAgaatttgccagttactttct	12	20	3	6	0	1	1	0	0	1	1	1	1	1	1	1	0	4	1	1	0	8	10			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:19566010A>T	uc001vuz.1	+	6	1108	c.1056_splice	c.e6-2	p.V352_splice	POTEG_uc001vva.1_Splice_Site|POTEG_uc010ahc.1_Splice_Site|uc001vvb.2_Intron	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G											ovary(1)	1						TTTTATACATAGAATTTGCCA	0.259													7	78					0	0	0	0	T	19566010	T	T	19566010	5	4	148	1	0	0	0	0	0	0	1	0	12321	434	15	5	1076	5	POTEG	14	19566010	Splice_Site	SNP	A	TCGA-CR-7379-01A-11D-2012-08		19566010	87783530	103	27161											
FOXG1	2290	broad.mit.edu	37	chr14	29237757	29237757	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcccccacgtcccgcacccGtcaatgacttcgcagagcag	8	7	8	18	4	1	2	1	1	0	1	4	2	3	2	4	0	1	3	4	0	1	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:29237757G>A	uc001wqe.2	+	1	1471	c.1272G>A	c.(1270-1272)CCG>CCA	p.P424P		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	424					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TCCCGCACCCGTCAATGACTT	0.657													15	47					0	0	0	0	A	29237757	A	A	29237757	2	1	148	1	0	0	0	0	0	0	0	1	6041	1132	40	1		1	FOXG1	14	29237757	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	9671747	29237757	78111783	104	27162											
PRKD1	5587	broad.mit.edu	37	chr14	30046528	30046528	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggctagcacttggattGatcaggtgtgtggggtactg	6	13	16	6	0	1	1	1	1	0	0	1	2	1	2	0	5	2	3	0	5	2	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:30046528G>T	uc001wqh.2	-	18	2836	c.2655C>A	c.(2653-2655)ATC>ATA	p.I885I		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	885					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CACTTGGATTGATCAGGTGTG	0.517													36	104					1.36161e-19	3.61633e-19	1	0	T	30046528	T	T	30046528	2	4	148	1	0	0	0	0	0	0	0	1	12580	1280	45	2		2	PRKD1	14	30046528	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	808771	30046528	77303012	105	27163											
HEATR5A	25938	broad.mit.edu	37	chr14	31762629	31762629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttatagcagcctcaaggCgggcttttagggctggagaa	9	10	13	9	1	1	1	1	0	0	1	1	2	1	1	2	4	2	3	2	4	5	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:31762629C>T	uc001wrf.3	-	30	5221	c.5144G>A	c.(5143-5145)CGC>CAC	p.R1715H	HEATR5A_uc010ami.2_Missense_Mutation_p.R1538H	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	2002							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		AGCCTCAAGGCGGGCTTTTAG	0.378													50	145					0	0	0	0	T	31762629	T	T	31762629	3	4	148	1	0	0	0	0	1	0	0	0	7070	768	27	1	121	1	HEATR5A	14	31762629	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	1716101	31762629	75586911	106	27164											
RPL10L	140801	broad.mit.edu	37	chr14	47120482	47120482	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaacttgaacttggccctgCgcaaggcttcaatcacatgc	10	9	10	12	1	2	1	2	1	0	0	2	2	2	2	1	3	4	2	1	3	4	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:47120482C>T	uc001wwg.2	-	1	547	c.458G>A	c.(457-459)CGC>CAC	p.R153H		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	153					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						CTTGGCCCTGCGCAAGGCTTC	0.517													12	76					0	0	0	0	T	47120482	T	T	47120482	3	4	148	1	0	0	0	0	1	0	0	0	13621	768	27	1	190	1	RPL10L	14	47120482	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	15357853	47120482	60229058	107	27165											
SOCS4	122809	broad.mit.edu	37	chr14	55509833	55509833	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtcggagcagaagtgccgAcagaaaagacggttatgtgt	13	8	14	6	3	0	3	0	0	0	3	1	5	0	4	1	2	2	2	1	2	5	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:55509833A>G	uc001xbo.2	+	3	639	c.74A>G	c.(73-75)GAC>GGC	p.D25G	SOCS4_uc001xbp.2_Missense_Mutation_p.D25G	NM_199421	NP_955453	Q8WXH5	SOCS4_HUMAN	suppressor of cytokine signaling 4	25					intracellular signal transduction|negative regulation of signal transduction|regulation of growth					ovary(1)|kidney(1)	2						AGAAGTGCCGACAGAAAAGAC	0.363													13	57					0	0	0	0	G	55509833	G	G	55509833	3	3	148	1	0	0	0	0	1	0	0	0	14980	275	10	5	76	5	SOCS4	14	55509833	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	8389351	55509833	51839707	108	27166											
ZBTB1	22890	broad.mit.edu	37	chr14	64989074	64989074	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgcacagacggacaaataCagaggagacacaagccaggc	16	3	11	11	1	1	3	0	0	1	3	1	5	1	4	1	3	3	1	1	3	3	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:64989074C>T	uc001xhh.3	+	4	1283	c.852C>T	c.(850-852)TAC>TAT	p.Y284Y	ZBTB1_uc010aqg.2_Silent_p.Y284Y|ZBTB1_uc001xhi.2_Silent_p.Y284Y	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	284					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		CGGACAAATACAGAGGAGACA	0.398													11	44					0	0	0	0	T	64989074	T	T	64989074	2	4	148	1	0	0	0	0	0	0	0	1	17589	489	17	4		4	ZBTB1	14	64989074	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	9479241	64989074	42360466	109	27167											
EIF2S1	1965	broad.mit.edu	37	chr14	67843302	67843302	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgatgcatttaagcatgcAgtctcgtaagaataccttct	12	14	7	8	1	2	2	0	1	2	1	3	2	2	2	1	0	4	4	1	0	5	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:67843302A>C	uc001xjg.2	+	4	609	c.468A>C	c.(466-468)GCA>GCC	p.A156A		NM_004094	NP_004085	P05198	IF2A_HUMAN	eukaryotic translation initiation factor 2,	156						cytosol|eukaryotic translation initiation factor 2 complex|polysome|stress granule	protein binding|ribosome binding|translation initiation factor activity			ovary(1)	1				all cancers(60;0.000683)|OV - Ovarian serous cystadenocarcinoma(108;0.00579)|BRCA - Breast invasive adenocarcinoma(234;0.00937)		TTAAGCATGCAGTCTCGTAAG	0.428													20	71					0	0	0	0	C	67843302	C	C	67843302	2	2	148	1	0	0	0	0	0	0	0	1	5031	175	7	5		5	EIF2S1	14	67843302	Silent	SNP	A	TCGA-CR-7379-01A-11D-2012-08	2854228	67843302	39506238	110	27168											
AHNAK2	113146	broad.mit.edu	37	chr14	105410852	105410852	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggccgataccctgaatgacgGcatcttgaatttgggcattt	9	12	11	9	2	1	3	0	3	1	0	1	4	1	3	2	3	1	2	2	3	3	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr14:105410852G>A	uc010axc.1	-	7	11056	c.10936C>T	c.(10936-10938)CCG>TCG	p.P3646S	AHNAK2_uc001ypx.2_Missense_Mutation_p.P3546S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3646						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGAATGACGGCATCTTGAAT	0.592													6	375					0	0	0	0	A	105410852	A	A	105410852	3	1	148	1	0	0	0	0	1	0	0	0	415	1203	42	4	6455	4	AHNAK2	14	105410852	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	37567550	105410852	1938688	111	27169											
EPB42	2038	broad.mit.edu	37	chr15	43503700	43503700	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcaacaagtactccatgcGctgagcctcattcttcagga	10	11	8	12	1	4	1	3	1	1	0	5	2	5	2	2	1	4	3	2	1	3	4	rs146473183		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:43503700G>A	uc001zra.3	-	4	763	c.463C>T	c.(463-465)CGC>TGC	p.R155C	EPB42_uc001zqz.3_5'Flank|EPB42_uc010bde.2_5'UTR|EPB42_uc001zrb.3_Missense_Mutation_p.R185C|EPB42_uc010udm.1_Missense_Mutation_p.R77C	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	155					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		TACTCCATGCGCTGAGCCTCA	0.582													29	56					0	0	0	0	A	43503700	A	A	43503700	3	1	148	1	0	0	0	0	1	0	0	0	5182	1087	38	1	1652	1	EPB42	15	43503700	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08		43503700	59027692	112	27170											
FBN1	2200	broad.mit.edu	37	chr15	48760184	48760184	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtaccccaggctttaccCagagaacagcagcaggaagc	13	4	12	12	0	0	1	0	0	0	1	0	4	0	3	3	3	6	4	3	3	4	3	rs143544916		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:48760184C>G	uc001zwx.1	-	38	5026	c.4698G>C	c.(4696-4698)CTG>CTC	p.L1566L	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1566	TB 6.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGGCTTTACCCAGAGAACAGC	0.453													17	63					0	0	0	0	G	48760184	G	G	48760184	2	3	148	1	0	0	0	0	0	0	0	1	5734	581	21	4		4	FBN1	15	48760184	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	5256484	48760184	53771208	113	27171											
SPPL2A	84888	broad.mit.edu	37	chr15	51031995	51031995	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctttttcctcatttctctAtcttcagttgtcactgcttt	4	23	3	11	0	6	0	3	0	3	0	8	0	7	0	1	0	1	2	1	0	1	8			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:51031995A>G	uc001zyv.2	-	6	795	c.615T>C	c.(613-615)GAT>GAC	p.D205D		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	signal peptide peptidase-like 2A	205						integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		TCATTTCTCTATCTTCAGTTG	0.318													14	54					0	0	0	0	G	51031995	G	G	51031995	2	3	148	1	0	0	0	0	0	0	0	1	15154	446	16	5		5	SPPL2A	15	51031995	Silent	SNP	A	TCGA-CR-7379-01A-11D-2012-08	2271811	51031995	51499397	114	27172											
BNC1	646	broad.mit.edu	37	chr15	83932492	83932492	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaagggagtatcccaggcGtgtttgctacctcggcaggc	7	8	16	10	2	0	0	0	0	0	0	2	2	1	2	2	5	2	4	2	5	3	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:83932492G>A	uc002bjt.1	-	4	1599	c.1511C>T	c.(1510-1512)ACG>ATG	p.T504M	BNC1_uc010uos.1_Missense_Mutation_p.T492M	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	504					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TATCCCAGGCGTGTTTGCTAC	0.512													27	67					0	0	0	0	A	83932492	A	A	83932492	3	1	148	1	0	0	0	0	1	0	0	0	1477	1145	40	1	1481	1	BNC1	15	83932492	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	32900497	83932492	18598900	115	27173											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84690198	84690198	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtaactggtcacattgttCtgccacctgtggtcatttgg	6	15	11	9	0	3	0	2	0	1	0	3	0	3	0	2	4	2	2	2	4	1	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:84690198C>G	uc002bjz.3	+	26	4534	c.4310C>G	c.(4309-4311)TCT>TGT	p.S1437C	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.S1437C|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.S1437C	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1437	TSP type-1 8.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCACATTGTTCTGCCACCTGT	0.517													14	212					0	0	0	0	G	84690198	G	G	84690198	3	3	148	1	0	0	0	0	1	0	0	0	276	913	32	2	4408	2	ADAMTSL3	15	84690198	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	757706	84690198	17841194	116	27174											
BLM	641	broad.mit.edu	37	chr15	91346818	91346818	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttattcacgacacaatgcCgaaagactttttaaaaagct	15	11	6	9	2	1	1	1	0	0	1	1	3	1	1	1	0	2	2	1	0	6	5	rs147148171		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:91346818C>T	uc002bpr.2	+	18	3523	c.3426C>T	c.(3424-3426)GCC>GCT	p.A1142A	BLM_uc010uqh.1_Silent_p.A1142A|BLM_uc010uqi.1_Silent_p.A767A|BLM_uc010bnx.2_Intron|BLM_uc002bpt.2_Silent_p.A117A	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	1142					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			GACACAATGCCGAAAGACTTT	0.373			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				21	61					0	0	0	0	T	91346818	T	T	91346818	2	4	148	1	0	0	0	0	0	0	0	1	1448	639	23	1		1	BLM	15	91346818	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	6656620	91346818	11184574	117	27175											
SV2B	9899	broad.mit.edu	37	chr15	91769696	91769696	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caagcaggccaagatggcgcCctccagaatggacagccttc	11	5	11	14	1	0	2	0	0	0	2	2	3	1	3	4	3	2	1	4	3	3	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr15:91769696C>T	uc002bqv.2	+	1	594	c.203C>T	c.(202-204)CCC>CTC	p.P68L	SV2B_uc002bqt.2_Missense_Mutation_p.P68L|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	68	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			AAGATGGCGCCCTCCAGAATG	0.577													18	44					0	0	0	0	T	91769696	T	T	91769696	3	4	148	1	0	0	0	0	1	0	0	0	15484	623	22	4	205	4	SV2B	15	91769696	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	422878	91769696	10761696	118	27176											
BTBD12	84464	broad.mit.edu	37	chr16	3646278	3646278	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggctggccgaaggcgaCgggcccctggagccacagcc	6	4	15	16	3	1	0	0	0	1	0	1	3	1	1	5	5	2	1	5	5	1	0			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:3646278C>T	uc002cvp.2	-	8	2427	c.1800G>A	c.(1798-1800)CCG>CCA	p.P600P		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	600	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CCGAAGGCGACGGGCCCCTGG	0.731								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				3	5					0	0	0	0	T	3646278	T	T	3646278	2	4	148	1	0	0	0	0	0	0	0	1	1545	523	19	1		1	BTBD12	16	3646278	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08		3646278	86708475	119	27177											
TMC7	79905	broad.mit.edu	37	chr16	19047109	19047109	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcactaaccgcagcatggcGgatctgaagcacagcagctt	12	7	10	12	2	2	1	1	1	1	0	2	2	2	2	1	2	5	5	1	2	2	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:19047109G>A	uc002dfq.2	+	7	1099	c.969G>A	c.(967-969)GCG>GCA	p.A323A	TMC7_uc010vao.1_Silent_p.A323A|TMC7_uc002dfp.2_Silent_p.A323A|TMC7_uc010vap.1_Silent_p.A213A	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	323	Cytoplasmic (Potential).					integral to membrane				skin(2)|ovary(1)	3						GCAGCATGGCGGATCTGAAGC	0.542													24	51					0	0	0	0	A	19047109	A	A	19047109	2	1	148	1	0	0	0	0	0	0	0	1	16056	1103	39	1		1	TMC7	16	19047109	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	15400831	19047109	71307644	120	27178											
ACSM5	54988	broad.mit.edu	37	chr16	20439133	20439133	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctccaaattcccgataacCaccctctgctgtgtcccaac	9	10	4	18	1	2	0	0	0	2	0	5	1	4	0	5	0	3	1	5	0	3	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:20439133C>A	uc002dhe.2	+	7	1092	c.945C>A	c.(943-945)ACC>ACA	p.T315T		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	315					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TCCCGATAACCACCCTCTGCT	0.478													58	152					6.12789e-21	1.63631e-20	1	0	A	20439133	A	A	20439133	2	1	148	1	0	0	0	0	0	0	0	1	187	581	21	4		4	ACSM5	16	20439133	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	1392024	20439133	69915620	121	27179											
ZNF423	23090	broad.mit.edu	37	chr16	49764836	49764836	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgctgttcctgtcttccagCgcacggctggttttctgatc	4	14	10	13	3	2	1	0	1	2	0	5	1	4	1	2	2	1	5	2	2	0	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:49764836C>T	uc002efs.2	-	4	421	c.123G>A	c.(121-123)GCG>GCA	p.A41A		NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	41					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				TGTCTTCCAGCGCACGGCTGG	0.512													39	248					0	0	0	0	T	49764836	T	T	49764836	2	4	148	1	0	0	0	0	0	0	0	1	17965	755	27	1		1	ZNF423	16	49764836	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	29325703	49764836	40589917	122	27180											
HYDIN	54768	broad.mit.edu	37	chr16	71163606	71163606	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctccctgcaccagcctcctCtgattcgcaaaggttcggga	7	10	9	15	2	2	1	0	1	2	0	6	2	3	2	4	2	2	3	4	2	1	2	rs79679861		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr16:71163606C>G	uc002ezr.2	-	9	1292	c.1164G>C	c.(1162-1164)CAG>CAC	p.Q388H	HYDIN_uc010cfz.1_Missense_Mutation_p.Q133H|HYDIN_uc002ezv.2_Missense_Mutation_p.Q388H|HYDIN_uc010vmc.1_Missense_Mutation_p.Q405H|HYDIN_uc010vmd.1_Missense_Mutation_p.Q415H|HYDIN_uc002ezw.3_Missense_Mutation_p.Q405H	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	388										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCAGCCTCCTCTGATTCGCAA	0.448													5	40					0	0	0	0	G	71163606	G	G	71163606	3	3	148	1	0	0	0	0	1	0	0	0	7506	912	32	2	14522	2	HYDIN	16	71163606	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	21398770	71163606	19191147	123	27181											
ZMYND15	84225	broad.mit.edu	37	chr17	4647997	4647997	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcactaaggagaaagggggCcgcagggacctgcagatcaa	13	3	16	9	1	1	2	1	0	0	2	1	4	1	3	2	5	1	3	2	5	3	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:4647997C>G	uc002fyt.2	+	10	1683	c.1644C>G	c.(1642-1644)GGC>GGG	p.G548G	ZMYND15_uc002fyv.2_Silent_p.G587G|ZMYND15_uc002fyu.2_Silent_p.G587G	NM_032265	NP_115641	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15 isoform 2	548							zinc ion binding				0						AGAAAGGGGGCCGCAGGGACC	0.622													7	69					0	0	0	0	G	4647997	G	G	4647997	2	3	148	1	0	0	0	0	0	0	0	1	17775	726	26	4		4	ZMYND15	17	4647997	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08		4647997	76547213	124	27182											
TP53	7157	broad.mit.edu	37	chr17	7578522	7578522	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acagggcaggtcttggccagTtggcaaaacatcttgttgag	10	10	13	8	0	2	1	0	1	2	0	2	1	2	1	1	4	1	4	1	4	2	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:7578522T>A	uc002gim.2	-	5	602	c.408A>T	c.(406-408)CAA>CAT	p.Q136H	TP53_uc002gig.1_Missense_Mutation_p.Q136H|TP53_uc002gih.2_Missense_Mutation_p.Q136H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Q4H|TP53_uc010cng.1_Missense_Mutation_p.Q4H|TP53_uc002gii.1_Missense_Mutation_p.Q4H|TP53_uc010cnh.1_Missense_Mutation_p.Q136H|TP53_uc010cni.1_Missense_Mutation_p.Q136H|TP53_uc002gij.2_Missense_Mutation_p.Q136H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Q43H|TP53_uc002gio.2_Missense_Mutation_p.Q4H|TP53_uc010vug.1_Missense_Mutation_p.Q97H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	136	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q136*(28)|p.0?(7)|p.Q136H(5)|p.Q136Q(4)|p.Q136P(3)|p.Q136E(3)|p.Q136fs*13(2)|p.N131fs*27(2)|p.Q136R(2)|p.Q136fs*34(2)|p.V73fs*9(1)|p.F134_T140>S(1)|p.C135_T140delCQLAKT(1)|p.Q136K(1)|p.C135_A138delCQLA(1)|p.K132_A138delKMFCQLA(1)|p.L137fs*12(1)|p.S127_Q136del10(1)|p.Q136_K139delQLAK(1)|p.C135_Q136insX(1)|p.C135_Q136insXXXXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTTGGCCAGTTGGCAAAACA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	44					0	0	0	0	A	7578522	A	A	7578522	3	1	148	1	0	0	0	0	1	0	0	0	16448	1722	60	5	890	5	TP53	17	7578522	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	2930525	7578522	73616688	125	27183											
C17orf68	80169	broad.mit.edu	37	chr17	8132760	8132760	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caggtagatgtggggcagggGaatgctaaataaatacaggg	14	7	16	4	0	0	1	0	0	0	1	0	2	0	2	0	6	2	3	0	6	7	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:8132760G>A	uc002gkq.3	-	19	3075	c.3016C>T	c.(3016-3018)CCC>TCC	p.P1006S	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	1006					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						TGGGGCAGGGGAATGCTAAAT	0.527													10	61					0	0	0	0	A	8132760	A	A	8132760	3	1	148	1	0	0	0	0	1	0	0	0	1883	1174	41	2	657	2	C17orf68	17	8132760	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	554238	8132760	73062450	126	27184											
SYNRG	11276	broad.mit.edu	37	chr17	35880712	35880712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcatttttaatcccaggccGtaacatacaggaggaaaaat	16	9	8	8	1	0	0	0	0	0	0	1	2	1	2	2	3	3	2	2	3	5	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:35880712G>A	uc002hoa.2	-	20	3789	c.3706C>T	c.(3706-3708)CGG>TGG	p.R1236W	SYNRG_uc010wde.1_Missense_Mutation_p.R1181W|SYNRG_uc010wdf.1_Missense_Mutation_p.R1158W|SYNRG_uc002hoc.2_Missense_Mutation_p.R1157W|SYNRG_uc002hoe.2_Missense_Mutation_p.R1158W|SYNRG_uc002hod.2_Missense_Mutation_p.R1113W|SYNRG_uc010wdg.1_Missense_Mutation_p.R1030W|SYNRG_uc002hob.2_Missense_Mutation_p.R1236W	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	1236					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						ATCCCAGGCCGTAACATACAG	0.517													14	52					0	0	0	0	A	35880712	A	A	35880712	3	1	148	1	0	0	0	0	1	0	0	0	15526	1144	40	1	250	1	SYNRG	17	35880712	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	27747952	35880712	45314498	127	27185											
KRT14	3861	broad.mit.edu	37	chr17	39740574	39740574	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaatctgcatctccaggtCagctctggccagggtcagtt	7	11	10	13	0	6	0	3	0	3	0	7	0	6	0	2	3	2	3	2	3	1	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:39740574C>A	uc002hxf.1	-	3	761	c.700G>T	c.(700-702)GAC>TAC	p.D234Y	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Missense_Mutation_p.D234Y	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	234	Coil 1B.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				ATCTCCAGGTCAGCTCTGGCC	0.522													6	172					0.00307968	0.00734957	1	0	A	39740574	A	A	39740574	3	1	148	1	0	0	0	0	1	0	0	0	8490	826	29	2	742	2	KRT14	17	39740574	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	3859862	39740574	41454636	128	27186											
RUNDC1	146923	broad.mit.edu	37	chr17	41142894	41142894	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggatgtgaagaaagtcCgggagacggggctgcacctg	11	5	17	8	2	0	4	0	1	0	3	1	6	1	5	2	4	1	2	2	4	2	0			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:41142894C>T	uc002ici.1	+	5	1015	c.1003C>T	c.(1003-1005)CGG>TGG	p.R335W	RUNDC1_uc010whi.1_Missense_Mutation_p.R105W	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	335											0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		GAAGAAAGTCCGGGAGACGGG	0.557													23	77					0	0	0	0	T	41142894	T	T	41142894	3	4	148	1	0	0	0	0	1	0	0	0	13807	643	23	1	1021	1	RUNDC1	17	41142894	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	1402320	41142894	40052316	129	27187											
KIAA1267	284058	broad.mit.edu	37	chr17	44110824	44110824	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaagatcaacctcccgcCagctgcaaaaccaagaacag	16	4	7	14	1	1	3	1	1	0	2	2	3	2	3	4	0	5	2	4	0	6	0			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:44110824C>T	uc002ikb.2	-	11	2754	c.2669G>A	c.(2668-2670)TGG>TAG	p.W890*	KIAA1267_uc002ikc.2_Nonsense_Mutation_p.W890*|KIAA1267_uc002ikd.2_Nonsense_Mutation_p.W890*|KIAA1267_uc010dav.2_Nonsense_Mutation_p.W889*|KIAA1267_uc010wkb.1_Nonsense_Mutation_p.W221*|KIAA1267_uc010wkc.1_Nonsense_Mutation_p.W158*	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	890						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				AACCTCCCGCCAGCTGCAAAA	0.498													4	36					0	0	0	0	T	44110824	T	T	44110824	4	4	148	1	0	0	0	0	0	1	0	0	8258	595	21	4	664	4	KIAA1267	17	44110824	Nonsense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	2967930	44110824	37084386	130	27188											
ITGB3	3690	broad.mit.edu	37	chr17	45361893	45361893	+	Frame_Shift_Del	DEL	C	-	-																															cttgatggacctgtcttactCcatgaaggatgatctgtgga																										TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:45361893delC	uc002ilj.2	+	4	466	c.446delC	c.(445-447)TCCfs	p.S149fs	ITGB3_uc002ili.1_Frame_Shift_Del_p.S149fs|ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	149	VWFA.|Extracellular (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	CTGTCTTACTCCATGAAGGAT	0.512													---	---	---								-	45361893	-	-	45361893	7	5	148	1	0	1	0	1	0	0	0	0	7934	855	30	0	460	0	ITGB3	17	45361893	Frame_Shift_Del	DEL	C	TCGA-CR-7379-01A-11D-2012-08	1251069	45361893	35833317	131	27189											
USP32	84669	broad.mit.edu	37	chr17	58329765	58329765	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ataatttgtccttcttcttcCggagtagctggtcttaaccc	7	16	7	11	1	3	0	0	0	3	0	5	1	5	1	3	2	2	2	3	2	3	7	rs61751977	byFrequency	TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:58329765C>T	uc002iyo.1	-	11	1399	c.1113G>A	c.(1111-1113)CCG>CCA	p.P371P	USP32_uc002iyn.1_Silent_p.P41P|USP32_uc010wov.1_Silent_p.P371P	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	371	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			CTTCTTCTTCCGGAGTAGCTG	0.328													6	22					0	0	0	0	T	58329765	T	T	58329765	2	4	148	1	0	0	0	0	0	0	0	1	17131	639	23	1		1	USP32	17	58329765	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	12967872	58329765	22865445	132	27190											
HGS	9146	broad.mit.edu	37	chr17	79658578	79658578	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggaggtgcgcgtgtgtgaGccctgctacgagcagctgaa	9	7	16	9	3	0	2	0	2	0	0	0	4	0	3	1	2	6	3	1	2	3	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr17:79658578G>A	uc002kbg.2	+	8	716	c.639G>A	c.(637-639)GAG>GAA	p.E213E	HGS_uc010wus.1_Silent_p.E213E	NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	213	FYVE-type.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			GCGTGTGTGAGCCCTGCTACG	0.602													34	91					0	0	0	0	A	79658578	A	A	79658578	2	1	148	1	0	0	0	0	0	0	0	1	7126	962	34	4		4	HGS	17	79658578	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	21328813	79658578	1536632	133	27191											
POTEC	388468	broad.mit.edu	37	chr18	14537869	14537869	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attaatttatcttcattgtgGacagcatagtgtagagtggt	11	16	10	4	0	2	1	1	0	1	1	2	2	2	2	0	2	1	2	0	2	4	7			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:14537869G>T	uc010dln.2	-	3	1195	c.741C>A	c.(739-741)GTC>GTA	p.V247V	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	247	ANK 4.									skin(3)	3						CTTCATTGTGGACAGCATAGT	0.353													40	82					4.34086e-07	1.08302e-06	1	0	T	14537869	T	T	14537869	2	4	148	1	0	0	0	0	0	0	0	1	12317	1161	41	2		2	POTEC	18	14537869	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08		14537869	63539379	134	27192											
TAF4B	6875	broad.mit.edu	37	chr18	23845146	23845146	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaatataggaaccgttttgaTtaaaagtaacagtggtccgt	15	12	9	5	2	0	1	0	1	0	0	1	2	1	2	2	2	2	2	2	2	7	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:23845146T>A	uc002kvu.3	+	2	845	c.356T>A	c.(355-357)ATT>AAT	p.I119N	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.I119N	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	119					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			ACCGTTTTGATTAAAAGTAAC	0.393													15	116					0	0	0	0	A	23845146	A	A	23845146	3	1	148	1	0	0	0	0	1	0	0	0	15593	1493	52	5	362	5	TAF4B	18	23845146	Missense_Mutation	SNP	T	TCGA-CR-7379-01A-11D-2012-08	9307277	23845146	54232102	135	27193											
KLHL14	57565	broad.mit.edu	37	chr18	30350279	30350279	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggctgctgctgctgtgaCggctgctgctgcggcggctg	1	9	19	12	4	0	1	0	1	0	0	0	1	0	1	0	5	6	8	0	5	0	0			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:30350279C>T	uc002kxm.1	-	2	664	c.276G>A	c.(274-276)CCG>CCA	p.P92P		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	92	BTB.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						gctgctgtgacggctgctgct	0.522													8	27					0	0	0	0	T	30350279	T	T	30350279	2	4	148	1	0	0	0	0	0	0	0	1	8409	523	19	1		1	KLHL14	18	30350279	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	6505133	30350279	47726969	136	27194											
DCC	1630	broad.mit.edu	37	chr18	50929242	50929242	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgagttggcagcctcccttgGaagccaatgggaaaattact	11	10	11	9	0	0	1	0	1	0	0	1	3	1	3	3	3	3	2	3	3	5	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:50929242G>A	uc002lfe.1	+	19	3501	c.2914G>A	c.(2914-2916)GAA>AAA	p.E972K	DCC_uc010xdr.1_Missense_Mutation_p.E800K|DCC_uc010dpf.1_Missense_Mutation_p.E607K	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	972	Extracellular (Potential).|Fibronectin type-III 6.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCCTCCCTTGGAAGCCAATGG	0.532													5	151					0	0	0	0	A	50929242	A	A	50929242	3	1	148	1	0	0	0	0	1	0	0	0	4299	1175	41	2	2988	2	DCC	18	50929242	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	20578963	50929242	27148006	137	27195											
DOK6	220164	broad.mit.edu	37	chr18	67425109	67425109	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgaaatctacagtttgcaaGgcaagtcactttaatgtaag	14	12	9	6	0	2	1	1	1	1	0	2	1	2	1	0	1	2	4	0	1	6	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr18:67425109G>T	uc002lkl.2	+	7	1046	c.856G>T	c.(856-858)GGT>TGT	p.G286C		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	286							insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				CAGTTTGCAAGGCAAGTCACT	0.438													5	46					0.00116845	0.00281567	1	0	T	67425109	T	T	67425109	3	4	148	1	0	0	0	0	1	0	0	0	4723	1014	35	4	882	4	DOK6	18	67425109	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	16495867	67425109	10652139	138	27196											
HMHA1	23526	broad.mit.edu	37	chr19	1080465	1080465	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agacgcctctttctccagccGggcgaggacaccaggttcac	8	7	11	15	3	3	1	1	0	2	1	4	3	3	2	4	3	1	1	4	3	0	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:1080465G>A	uc002lqz.1	+	15	2062	c.1831G>A	c.(1831-1833)GGG>AGG	p.G611R	HMHA1_uc010xgd.1_Missense_Mutation_p.G627R|HMHA1_uc010xge.1_Missense_Mutation_p.G479R|HMHA1_uc002lra.1_Missense_Mutation_p.G451R|HMHA1_uc002lrb.1_Missense_Mutation_p.G494R|HMHA1_uc002lrc.1_Missense_Mutation_p.G246R|HMHA1_uc002lrd.1_5'Flank|HMHA1_uc010dsd.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	611					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTCCAGCCGGGCGAGGACA	0.692													11	57					0	0	0	0	A	1080465	A	A	1080465	3	1	148	1	0	0	0	0	1	0	0	0	7279	1116	39	1	1889	1	HMHA1	19	1080465	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08		1080465	58048518	139	27197											
MUC16	94025	broad.mit.edu	37	chr19	9085508	9085508	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctgtttctggatttctttGcttagcagcagatgtggatg	6	17	11	7	0	3	1	0	0	3	1	3	3	3	3	0	2	3	4	0	2	1	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:9085508G>A	uc002mkp.2	-	1	6511	c.6307C>T	c.(6307-6309)CAA>TAA	p.Q2103*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2103	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGATTTCTTTGCTTAGCAGCA	0.488													24	218					0	0	0	0	A	9085508	A	A	9085508	4	1	148	1	0	0	0	0	0	1	0	0	10026	1328	46	4	37552	4	MUC16	19	9085508	Nonsense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	8005043	9085508	50043475	140	27198											
RDH8	50700	broad.mit.edu	37	chr19	10129435	10129435	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctggaatgggcctggtgggGcccctggaggggctcagcct	4	7	19	11	0	1	0	1	0	0	0	1	2	1	2	4	8	1	2	4	8	1	0			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:10129435G>T	uc002mmr.2	+	3	540	c.291G>T	c.(289-291)GGG>GGT	p.G97G		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	97	Helical; (Potential).				estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	GCCTGGTGGGGCCCCTGGAGG	0.507													23	138					1.10513e-12	2.88855e-12	1	0	T	10129435	T	T	10129435	2	4	148	1	0	0	0	0	0	0	0	1	13261	1190	42	4		4	RDH8	19	10129435	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	1043927	10129435	48999548	141	27199											
MAN2B1	4125	broad.mit.edu	37	chr19	12763060	12763060	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgaggcctggtcactttcGttgtcacctatactggcgtt	5	14	10	12	2	2	1	2	1	0	0	3	1	2	1	3	3	1	2	3	3	2	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:12763060G>A	uc002mub.2	-	16	2029	c.1953C>T	c.(1951-1953)AAC>AAT	p.N651N	MAN2B1_uc010dyv.1_Silent_p.N650N	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	651					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						GGTCACTTTCGTTGTCACCTA	0.602													22	94					0	0	0	0	A	12763060	A	A	12763060	2	1	148	1	0	0	0	0	0	0	0	1	9269	1136	40	1		1	MAN2B1	19	12763060	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	2633625	12763060	46365923	142	27200											
ZNF101	94039	broad.mit.edu	37	chr19	19790618	19790618	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttcggacacatgaaatcAgatctcacgcgctggagaaa	14	7	9	11	3	2	3	2	1	1	2	4	5	2	4	1	2	0	1	1	2	2	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:19790618A>C	uc002nni.1	+	4	930	c.820A>C	c.(820-822)AGA>CGA	p.R274R	ZNF101_uc010ecg.1_Silent_p.R154R|ZNF101_uc002nnj.1_Silent_p.R154R	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	274	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ACATGAAATCAGATCTCACGC	0.423													4	35					0	0	0	0	C	19790618	C	C	19790618	2	2	148	1	0	0	0	0	0	0	0	1	17781	180	7	5		5	ZNF101	19	19790618	Silent	SNP	A	TCGA-CR-7379-01A-11D-2012-08	7027558	19790618	39338365	143	27201											
ZNF14	7561	broad.mit.edu	37	chr19	19822565	19822565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaaaactgaaggttttacCgcatagtttacattcatagg	14	13	8	6	1	1	2	1	2	0	0	1	2	1	2	1	2	3	3	1	2	7	7			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:19822565C>T	uc002nnk.1	-	4	1679	c.1525G>A	c.(1525-1527)GGT>AGT	p.G509S		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	509	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				AAGGTTTTACCGCATAGTTTA	0.393													18	122					0	0	0	0	T	19822565	T	T	19822565	3	4	148	1	0	0	0	0	1	0	0	0	17795	652	23	1	407	1	ZNF14	19	19822565	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	31947	19822565	39306418	144	27202											
ZNF99	7652	broad.mit.edu	37	chr19	22941431	22941431	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctttgccacattcttcaCatttgcagggtttctctgca	8	15	7	11	0	3	0	1	0	2	0	4	0	3	0	1	1	4	4	1	1	1	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:22941431C>A	uc010xrh.1	-	5	1007	c.1007G>T	c.(1006-1008)TGT>TTT	p.C336F		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACATTCTTCACATTTGCAGGG	0.373													29	65					1.75199e-13	4.60362e-13	1	0	A	22941431	A	A	22941431	3	1	148	1	0	0	0	0	1	0	0	0	18271	478	17	4	2117	4	ZNF99	19	22941431	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	3118866	22941431	36187552	145	27203											
WDR62	284403	broad.mit.edu	37	chr19	36572390	36572390	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatcaggatcctttctgaCttgttcttcagacaacacca	10	12	6	13	0	4	2	2	1	2	1	5	3	5	3	3	1	1	1	3	1	1	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:36572390C>T	uc002odc.2	+	10	1380	c.1289C>T	c.(1288-1290)ACT>ATT	p.T430I	WDR62_uc002odd.2_Missense_Mutation_p.T430I	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	430	WD 6.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TCCTTTCTGACTTGTTCTTCA	0.468													15	115					0	0	0	0	T	36572390	T	T	36572390	3	4	148	1	0	0	0	0	1	0	0	0	17381	565	20	4	1327	4	WDR62	19	36572390	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	13630959	36572390	22556593	146	27204											
SFRS16	11129	broad.mit.edu	37	chr19	45556084	45556084	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacaccaacaacatgattgAccgattcgatgtccgtgccc	11	8	9	13	3	0	2	0	2	0	0	2	5	1	3	4	1	3	0	4	1	2	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:45556084A>G	uc002pak.2	+	4	331	c.233A>G	c.(232-234)GAC>GGC	p.D78G	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Intron|SFRS16_uc002pam.2_Missense_Mutation_p.D78G|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	78					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AACATGATTGACCGATTCGAT	0.602													17	43					0	0	0	0	G	45556084	G	G	45556084	3	3	148	1	0	0	0	0	1	0	0	0	14237	275	10	5	243	5	SFRS16	19	45556084	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	8983694	45556084	13572899	147	27205											
TMC4	147798	broad.mit.edu	37	chr19	54666830	54666830	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcggagtcgcccccacaaGtgatctgattccagagagag	10	7	11	13	2	1	4	0	2	1	2	4	6	2	5	4	1	0	0	4	1	1	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:54666830G>A	uc010erf.2	-	9	1490	c.1358C>T	c.(1357-1359)ACT>ATT	p.T453I	TMC4_uc002qdn.2_Missense_Mutation_p.T167I|TMC4_uc002qdo.2_Missense_Mutation_p.T447I	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	453	Cytoplasmic (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCCCCACAAGTGATCTGATT	0.582													25	48					0	0	0	0	A	54666830	A	A	54666830	3	1	148	1	0	0	0	0	1	0	0	0	16053	1029	36	4	808	4	TMC4	19	54666830	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	9110746	54666830	4462153	148	27206											
ZIM3	114026	broad.mit.edu	37	chr19	57648260	57648260	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgcacggccacttcccagCacttcctcttcctccaacca	7	9	4	21	1	1	0	0	0	1	0	5	0	5	0	7	1	3	2	7	1	1	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr19:57648260C>T	uc002qnz.1	-	4	608	c.222G>A	c.(220-222)GTG>GTA	p.V74V		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	74	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CACTTCCCAGCACTTCCTCTT	0.517													13	81					0	0	0	0	T	57648260	T	T	57648260	2	4	148	1	0	0	0	0	0	0	0	1	17752	697	25	4		4	ZIM3	19	57648260	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	2981430	57648260	1480723	149	27207											
LBP	3929	broad.mit.edu	37	chr20	36992665	36992665	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagtttcgccgacattgattAtagcttagtggaagcccctc	9	12	9	11	2	0	1	0	1	0	0	2	3	0	2	3	1	2	2	3	1	4	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr20:36992665A>T	uc002xic.1	+	7	724	c.689A>T	c.(688-690)TAT>TTT	p.Y230F		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	230					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				GACATTGATTATAGCTTAGTG	0.557													16	40					0	0	0	0	T	36992665	T	T	36992665	3	4	148	1	0	0	0	0	1	0	0	0	8691	449	16	5	715	5	LBP	20	36992665	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08		36992665	26032855	150	27208											
C20orf111	51526	broad.mit.edu	37	chr20	42825851	42825851	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacagagttctggcgtgcagCgactgagagtagtcctcaag	10	8	14	9	2	2	2	1	1	1	2	3	5	3	2	1	1	2	3	1	1	2	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr20:42825851C>T	uc002xlk.2	-	4	857	c.720G>A	c.(718-720)TCG>TCA	p.S240S		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	240											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			TGGCGTGCAGCGACTGAGAGT	0.532													8	102					0	0	0	0	T	42825851	T	T	42825851	2	4	148	1	0	0	0	0	0	0	0	1	2090	755	27	1		1	C20orf111	20	42825851	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	5833186	42825851	20199669	151	27209											
FOXRED2	80020	broad.mit.edu	37	chr22	36900343	36900343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcaggatggccagatccGtcaggtcagactcgagcagc	9	7	12	13	2	3	2	3	0	0	2	5	4	4	3	3	3	2	1	3	3	0	1	rs142793535		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr22:36900343G>A	uc003apn.3	-	3	959	c.851C>T	c.(850-852)ACG>ATG	p.T284M	FOXRED2_uc003apo.3_Missense_Mutation_p.T284M|FOXRED2_uc003app.3_Missense_Mutation_p.T284M	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	284					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						GGCCAGATCCGTCAGGTCAGA	0.562													24	46					0	0	0	0	A	36900343	A	A	36900343	3	1	148	1	0	0	0	0	1	0	0	0	6068	1145	40	1	1227	1	FOXRED2	22	36900343	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08		36900343	14404223	152	27210											
CBX7	23492	broad.mit.edu	37	chr22	39529912	39529912	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgattcagaacttcccactgCggtctcggaagaagccctca	10	9	9	13	2	3	3	2	1	1	2	5	4	4	4	2	2	3	0	2	2	3	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr22:39529912C>A	uc003axb.2	-	6	829	c.740G>T	c.(739-741)CGC>CTC	p.R247L	CBX7_uc003axc.2_Missense_Mutation_p.R154L	NM_175709	NP_783640	O95931	CBX7_HUMAN	chromobox homolog 7	247					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				ovary(1)	1	Melanoma(58;0.04)					CTTCCCACTGCGGTCTCGGAA	0.577													12	74					9.31168e-06	2.27721e-05	1	0	A	39529912	A	A	39529912	3	1	148	1	0	0	0	0	1	0	0	0	2735	768	27	3	19	3	CBX7	22	39529912	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	2629569	39529912	11774654	153	27211											
MKL1	57591	broad.mit.edu	37	chr22	40815260	40815260	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggatagaggtggcggcAggggccttgggggctcctgg	5	7	21	8	1	0	1	0	0	0	1	1	2	1	2	2	9	1	3	2	9	1	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr22:40815260A>G	uc003ayv.1	-	9	1389	c.1182T>C	c.(1180-1182)CCT>CCC	p.P394P	MKL1_uc003ayw.1_Silent_p.P394P|MKL1_uc010gye.1_Silent_p.P394P|MKL1_uc010gyf.1_Silent_p.P344P	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	394					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AGGTGGCGGCAGGGGCCTTGG	0.657			T	RBM15	acute megakaryocytic leukemia								6	16					0	0	0	0	G	40815260	G	G	40815260	2	3	148	1	0	0	0	0	0	0	0	1	9654	175	7	5		5	MKL1	22	40815260	Silent	SNP	A	TCGA-CR-7379-01A-11D-2012-08	1285348	40815260	10489306	154	27212											
IL17REL	400935	broad.mit.edu	37	chr22	50439548	50439548	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgcgtacacgcaggagcatCgcgcagccgtcagaggggac	9	3	16	13	6	1	1	1	0	0	1	2	3	1	3	1	3	3	4	1	3	1	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr22:50439548C>T	uc003bje.1	-	4	304	c.72G>A	c.(70-72)GCG>GCA	p.A24A		NM_001001694	NP_001001694	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	24										pancreas(1)	1		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GCAGGAGCATCGCGCAGCCGT	0.662													6	11					0	0	0	0	T	50439548	T	T	50439548	2	4	148	1	0	0	0	0	0	0	0	1	7683	871	31	1		1	IL17REL	22	50439548	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	9624288	50439548	865018	155	27213											
LMF2	91289	broad.mit.edu	37	chr22	50943500	50943500	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acccaccaggctaatcaggaAcaaggccacggtcgcagtgc	12	4	11	14	2	1	0	1	0	0	0	2	1	1	1	3	4	2	2	3	4	3	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chr22:50943500A>G	uc003blp.2	-	9	1271	c.1240T>C	c.(1240-1242)TTC>CTC	p.F414L	LMF2_uc010hba.2_Missense_Mutation_p.F236L|LMF2_uc003blo.2_Missense_Mutation_p.F389L	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	414	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTAATCAGGAACAAGGCCACG	0.647													12	41					0	0	0	0	G	50943500	G	G	50943500	3	3	148	1	0	0	0	0	1	0	0	0	8888	43	2	5	907	5	LMF2	22	50943500	Missense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	503952	50943500	361066	156	27214											
FANCB	2187	broad.mit.edu	37	chrX	14861944	14861944	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcatgtttagctatggcAgaagaaagagaactaagggt	14	11	11	5	0	1	3	1	0	0	3	1	4	1	3	0	2	2	3	0	2	6	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:14861944A>C	uc004cwg.1	-	10	2593	c.2325T>G	c.(2323-2325)TCT>TCG	p.S775S	FANCB_uc004cwh.1_Silent_p.S775S	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	775					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					TAGCTATGGCAGAAGAAAGAG	0.383								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				14	71					0	0	0	0	C	14861944	C	C	14861944	2	2	148	1	0	0	0	0	0	0	0	1	5695	175	7	5		5	FANCB	23	14861944	Silent	SNP	A	TCGA-CR-7379-01A-11D-2012-08		14861944	140408616	157	27215											
LANCL3	347404	broad.mit.edu	37	chrX	37431412	37431412	+	Nonsense_Mutation	SNP	A	T	T																															aacgctacctgcgctcggctAagcgcctcatcgacgcgtgc																										TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:37431412A>T	uc011mkd.1	+	1	591	c.289A>T	c.(289-291)AAG>TAG	p.K97*	LANCL3_uc004ddp.1_Nonsense_Mutation_p.K97*	NM_198511	NP_940913	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3	97							catalytic activity				0						GCGCTCGGCTAAGCGCCTCAT	0.716													4	13					0	0	0	0	T	37431412	T	T	37431412	4	4	148	1	0	0	0	0	0	1	0	0	8662	363	13	5	291	5	LANCL3	23	37431412	Nonsense_Mutation	SNP	A	TCGA-CR-7379-01A-11D-2012-08	22569468	37431412	117839148	158	27216	53	2									
LANCL3	347404	broad.mit.edu	37	chrX	37431414	37431414	+	Silent	SNP	G	A	A																															cgctacctgcgctcggctaaGcgcctcatcgacgcgtgcgc																										TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:37431414G>A	uc011mkd.1	+	1	593	c.291G>A	c.(289-291)AAG>AAA	p.K97K	LANCL3_uc004ddp.1_Silent_p.K97K	NM_198511	NP_940913	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3	97							catalytic activity				0						GCTCGGCTAAGCGCCTCATCG	0.716													4	13					0	0	0	0	A	37431414	A	A	37431414	2	1	148	1	0	0	0	0	0	0	0	1	8662	962	34	4		4	LANCL3	23	37431414	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	2	37431414	117839146	159	27217	53	2									
SUV39H1	6839	broad.mit.edu	37	chrX	48564736	48564736	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacctctttgacctggactaCgtggaggacgtgtacaccgt	8	11	11	11	3	1	1	0	1	1	0	1	4	1	4	3	3	3	1	3	3	3	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:48564736C>A	uc004dkn.2	+	4	954	c.909C>A	c.(907-909)TAC>TAA	p.Y303*	SUV39H1_uc011mmf.1_Nonsense_Mutation_p.Y314*|SUV39H1_uc011mmg.1_RNA	NM_003173	NP_003164	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1	303	Mediates interaction with MECOM (By similarity).|SET.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding				0						ACCTGGACTACGTGGAGGACG	0.612													13	69					6.31663e-08	1.58397e-07	1	0	A	48564736	A	A	48564736	4	1	148	1	0	0	0	0	0	1	0	0	15478	547	19	3	923	3	SUV39H1	23	48564736	Nonsense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	11133322	48564736	106705824	160	27218											
FOXR2	139628	broad.mit.edu	37	chrX	55650595	55650595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggtatccattcccccagtGactttgagctcacagaagag	11	9	10	11	0	1	4	1	2	0	2	3	4	3	4	3	1	1	2	3	1	2	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:55650595G>A	uc004duo.2	+	1	763	c.451G>A	c.(451-453)GAC>AAC	p.D151N		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	151					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						TTCCCCCAGTGACTTTGAGCT	0.502													9	54					0	0	0	0	A	55650595	A	A	55650595	3	1	148	1	0	0	0	0	1	0	0	0	6066	1290	45	2	453	2	FOXR2	23	55650595	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	7085859	55650595	99619965	161	27219											
VSIG4	11326	broad.mit.edu	37	chrX	65253341	65253341	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacacggagctcagtaatCttatctctcacgacttggtt	9	13	9	10	2	4	0	2	0	2	0	5	3	4	2	0	3	1	3	0	3	2	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:65253341C>A	uc004dwh.2	-	2	514	c.387G>T	c.(385-387)AAG>AAT	p.K129N	VSIG4_uc004dwi.2_Missense_Mutation_p.K129N|VSIG4_uc010nkq.1_Missense_Mutation_p.K129N|VSIG4_uc004dwj.2_Missense_Mutation_p.K129N|VSIG4_uc011moy.1_Missense_Mutation_p.K129N|VSIG4_uc004dwk.2_Missense_Mutation_p.K129N|VSIG4_uc004dwl.2_Missense_Mutation_p.K25N	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	129	Ig-like 1.|Extracellular (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						GCTCAGTAATCTTATCTCTCA	0.473													28	121					1.16021e-09	2.96965e-09	1	0	A	65253341	A	A	65253341	3	1	148	1	0	0	0	0	1	0	0	0	17293	912	32	2	844	2	VSIG4	23	65253341	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	9602746	65253341	90017219	162	27220											
ZMYM3	9203	broad.mit.edu	37	chrX	70461117	70461117	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atagaacttgacagggcagcGgaggggattcatgcggttct	10	9	15	7	2	2	2	1	1	1	1	2	4	2	4	0	5	3	2	0	5	2	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:70461117G>A	uc004dzh.1	-	24	3967	c.3880C>T	c.(3880-3882)CGC>TGC	p.R1294C	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.R1294C|ZMYM3_uc004dzj.1_Missense_Mutation_p.R1282C	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1294					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					ACAGGGCAGCGGAGGGGATTC	0.507													5	39					0	0	0	0	A	70461117	A	A	70461117	3	1	148	1	0	0	0	0	1	0	0	0	17768	1116	39	1	240	1	ZMYM3	23	70461117	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	5207776	70461117	84809443	163	27221											
ERCC6L	54821	broad.mit.edu	37	chrX	71425660	71425660	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaaccctgctctggaattaGgtgcagagccacacaagcta	13	7	9	12	0	1	1	0	0	1	1	1	2	1	2	2	2	5	3	2	2	5	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:71425660G>C	uc004eaq.1	-	2	3054	c.2957C>G	c.(2956-2958)CCT>CGT	p.P986R	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Missense_Mutation_p.P863R	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	986					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					TCTGGAATTAGGTGCAGAGCC	0.393													30	59					0	0	0	0	C	71425660	C	C	71425660	3	2	148	1	0	0	0	0	1	0	0	0	5242	1000	35	4	799	4	ERCC6L	23	71425660	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	964543	71425660	83844900	164	27222											
ARMCX3	51566	broad.mit.edu	37	chrX	100879979	100879979	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggacgattgcatgggctacGccaggaaagtaggctgggtg	9	7	18	7	2	0	0	0	0	0	0	0	3	0	2	1	5	2	4	1	5	3	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:100879979G>A	uc004ehz.1	+	5	543	c.10G>A	c.(10-12)GCC>ACC	p.A4T	ARMCX3_uc004eia.1_Missense_Mutation_p.A4T|ARMCX3_uc004eib.1_Missense_Mutation_p.A4T|ARMCX3_uc004eic.1_Missense_Mutation_p.A4T	NM_016607	NP_057691	Q9UH62	ARMX3_HUMAN	armadillo repeat containing, X-linked 3	4						integral to membrane	binding			ovary(1)|lung(1)	2						CATGGGCTACGCCAGGAAAGT	0.557													15	80					0	0	0	0	A	100879979	A	A	100879979	3	1	148	1	0	0	0	0	1	0	0	0	963	1087	38	1	12	1	ARMCX3	23	100879979	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	29454319	100879979	54390581	165	27223											
NXF5	55998	broad.mit.edu	37	chrX	101095787	101095787	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggagagattcagggtcttGactttgggagccttctctgt	6	15	13	7	0	3	2	1	1	2	1	4	5	3	4	1	3	1	0	1	3	0	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:101095787G>C	uc011mrk.1	-	9	921	c.561C>G	c.(559-561)GTC>GTG	p.V187V	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	187	LRR 2.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TCAGGGTCTTGACTTTGGGAG	0.478													5	44					0	0	0	0	C	101095787	C	C	101095787	2	2	148	1	0	0	0	0	0	0	0	1	10840	1277	45	2		2	NXF5	23	101095787	Silent	SNP	G	TCGA-CR-7379-01A-11D-2012-08	215808	101095787	54174773	166	27224											
NXF3	56000	broad.mit.edu	37	chrX	102337969	102337969	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggatatcaagagcttcCtgggagacatcacactgttg	10	11	10	10	0	3	2	2	0	1	2	4	4	4	3	1	2	1	2	1	2	2	3			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:102337969C>T	uc004eju.2	-	7	725	c.654G>A	c.(652-654)CAG>CAA	p.Q218Q	NXF3_uc010noi.1_Silent_p.Q68Q|NXF3_uc011mrw.1_Silent_p.Q218Q|NXF3_uc011mrx.1_Silent_p.Q129Q	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	218						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CAAGAGCTTCCTGGGAGACAT	0.498													33	308					0	0	0	0	T	102337969	T	T	102337969	2	4	148	1	0	0	0	0	0	0	0	1	10839	680	24	4		4	NXF3	23	102337969	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	1242182	102337969	52932591	167	27225											
HTR2C	3358	broad.mit.edu	37	chrX	114141460	114141460	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaccaagaccagaacgcaCgccgaagaaagaagaaggag	19	1	11	10	3	0	5	0	0	0	5	0	7	0	6	3	1	2	1	3	1	7	1			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:114141460C>T	uc004epu.1	+	6	1587	c.859C>T	c.(859-861)CGC>TGC	p.R287C	HTR2C_uc010nqc.1_Missense_Mutation_p.R287C|HTR2C_uc004epv.1_3'UTR	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	287	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	CCAGAACGCACGCCGAAGAAA	0.493													20	141					0	0	0	0	T	114141460	T	T	114141460	3	4	148	1	0	0	0	0	1	0	0	0	7482	536	19	1	873	1	HTR2C	23	114141460	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	11803491	114141460	41129100	168	27226											
PGRMC1	10857	broad.mit.edu	37	chrX	118370576	118370576	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgcggcgcttcgacggcGtccaggacccgcgcatactc	6	6	13	16	7	0	0	0	0	0	0	3	2	1	1	2	3	3	3	2	3	1	2			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:118370576G>A	uc004erb.2	+	1	366	c.250G>A	c.(250-252)GTC>ATC	p.V84I	PGRMC1_uc011mts.1_Missense_Mutation_p.V84I	NM_006667	NP_006658	O00264	PGRC1_HUMAN	progesterone receptor membrane component 1	84	Cytochrome b5 heme-binding.|Cytoplasmic (Potential).					cell surface|endoplasmic reticulum membrane|integral to membrane|microsome|nucleolus	heme binding|protein binding|receptor activity|steroid binding				0						CTTCGACGGCGTCCAGGACCC	0.721													4	30					0	0	0	0	A	118370576	A	A	118370576	3	1	148	1	0	0	0	0	1	0	0	0	11861	1145	40	1	252	1	PGRMC1	23	118370576	Missense_Mutation	SNP	G	TCGA-CR-7379-01A-11D-2012-08	4229116	118370576	36899984	169	27227											
ODZ1	10178	broad.mit.edu	37	chrX	123518065	123518065	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtaggctttctgcagcaggCcattagaattatattcaaaa	13	13	8	7	0	2	1	1	0	1	1	2	1	2	1	1	2	2	4	1	2	7	6			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:123518065C>G	uc004euj.2	-	29	6759	c.6695G>C	c.(6694-6696)GGC>GCC	p.G2232A	ODZ1_uc011muj.1_Missense_Mutation_p.G2238A|ODZ1_uc010nqy.2_Missense_Mutation_p.G2239A	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2232	YD 20.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTGCAGCAGGCCATTAGAATT	0.463													9	82					0	0	0	0	G	123518065	G	G	123518065	3	3	148	1	0	0	0	0	1	0	0	0	10888	739	26	4	1494	4	ODZ1	23	123518065	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	5147489	123518065	31752495	170	27228											
MAGEA4	4103	broad.mit.edu	37	chrX	151092703	151092703	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgggcctttcctatgatggCctgctgggtaataatcagat	8	13	11	9	0	1	2	1	1	0	1	2	2	2	2	3	3	1	2	3	3	3	4			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:151092703C>G	uc004fez.2	+	3	723	c.567C>G	c.(565-567)GGC>GGG	p.G189G	MAGEA4_uc004ffa.2_Silent_p.G189G|MAGEA4_uc004ffb.2_Silent_p.G189G|MAGEA4_uc004ffc.2_Silent_p.G189G|MAGEA4_uc004ffd.2_Silent_p.G189G	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	189	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATGATGGCCTGCTGGGTA	0.537													15	161					0	0	0	0	G	151092703	G	G	151092703	2	3	148	1	0	0	0	0	0	0	0	1	9219	726	26	4		4	MAGEA4	23	151092703	Silent	SNP	C	TCGA-CR-7379-01A-11D-2012-08	27574638	151092703	4177857	171	27229											
MPP1	4354	broad.mit.edu	37	chrX	154013398	154013398	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggactgcagctcggggcttCgctaggagctgactgagcca	7	7	16	11	2	0	2	0	2	0	0	2	4	0	4	1	4	4	5	1	4	1	2	rs146674414		TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:154013398C>T	uc004fmp.1	-	7	827	c.712G>A	c.(712-714)GAA>AAA	p.E238K	MPP1_uc010nvg.1_Missense_Mutation_p.E218K|MPP1_uc011mzv.1_Missense_Mutation_p.E208K|MPP1_uc004fmq.1_Missense_Mutation_p.E192K|MPP1_uc011mzw.1_Missense_Mutation_p.E221K|MPP1_uc010nvh.1_Missense_Mutation_p.E112K	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	238					regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTCGGGGCTTCGCTAGGAGCT	0.552													4	25					0	0	0	0	T	154013398	T	T	154013398	3	4	148	1	0	0	0	0	1	0	0	0	9786	893	31	1	712	1	MPP1	23	154013398	Missense_Mutation	SNP	C	TCGA-CR-7379-01A-11D-2012-08	2920695	154013398	1257162	172	27230											
F8	2157	broad.mit.edu	37	chrX	154159320	154159320	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacttgtattatcagtaccTgctgccaaattgtctgatgg	10	14	9	8	0	2	1	1	1	1	0	2	2	2	1	2	1	4	3	2	1	5	5			TCGA-CR-7379-01A-11D-2012-08	TCGA-CR-7379-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8cc45c01-a363-4151-9ea0-32c404b79da4	fccf77bc-8678-467a-bef2-24001108bacf	g.chrX:154159320T>G	uc004fmt.2	-	14	2916	c.2745A>C	c.(2743-2745)GCA>GCC	p.A915A		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	915	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TATCAGTACCTGCTGCCAAAT	0.378													5	82					0	0	0	0	G	154159320	G	G	154159320	2	3	148	1	0	0	0	0	0	0	0	1	5375	1567	55	5		5	F8	23	154159320	Silent	SNP	T	TCGA-CR-7379-01A-11D-2012-08	145922	154159320	1111240	173	27231											
IL22RA1	58985	broad.mit.edu	37	chr1	24460838	24460838	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcatctgaatcgatctcaCtttggagatacaggtcacat	13	12	7	9	1	4	2	3	1	2	1	6	4	4	2	0	2	1	0	0	2	3	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:24460838C>T	uc001biq.1	-	4	433	c.394G>A	c.(394-396)GTG>ATG	p.V132M	IL22RA1_uc010oeg.1_Missense_Mutation_p.V24M|IL22RA1_uc009vrb.1_Translation_Start_Site|IL22RA1_uc010oeh.1_Missense_Mutation_p.V132M	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	132	Extracellular (Potential).					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		ATCGATCTCACTTTGGAGATA	0.507													27	25					0	0	0	0	T	24460838	T	T	24460838	3	4	149	1	0	0	0	0	1	0	0	0	7712	565	20	4	1346	4	IL22RA1	1	24460838	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08		24460838	224789783	1	27232											
ZNF362	149076	broad.mit.edu	37	chr1	33745945	33745945	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcttggcccccccaagtcCgaacgcggccgcaaaaagat	10	5	10	16	4	0	1	0	0	0	1	1	2	1	1	5	2	2	2	5	2	4	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:33745945C>T	uc001bxc.1	+	5	740	c.570C>T	c.(568-570)TCC>TCT	p.S190S		NM_152493	NP_689706	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CCCCCAAGTCCGAACGCGGCC	0.657													18	52					0	0	0	0	T	33745945	T	T	33745945	2	4	149	1	0	0	0	0	0	0	0	1	17935	639	23	1		1	ZNF362	1	33745945	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08	9285107	33745945	215504676	2	27233											
SMAP2	64744	broad.mit.edu	37	chr1	40839835	40839835	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtggatcggtaccaggctGtcctggccaacctgctgctg	6	9	13	13	2	0	0	0	0	0	0	2	1	1	1	4	4	4	4	4	4	2	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:40839835G>C	uc001cfj.2	+	1	108	c.43G>C	c.(43-45)GTC>CTC	p.V15L	SMAP2_uc010ojh.1_Missense_Mutation_p.V15L|SMAP2_uc001cfk.2_5'Flank	NM_022733	NP_073570	Q8WU79	SMAP2_HUMAN	small ArfGAP2	15	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm|nucleus	ARF GTPase activator activity|zinc ion binding				0	Lung NSC(20;1.56e-05)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.04e-17)			GTACCAGGCTGTCCTGGCCAA	0.662													12	22					0	0	0	0	C	40839835	C	C	40839835	3	2	149	1	0	0	0	0	1	0	0	0	14831	1377	48	4	45	4	SMAP2	1	40839835	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	7093890	40839835	208410786	3	27234											
PTPRF	5792	broad.mit.edu	37	chr1	44085423	44085423	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcaacaagttcaagaacCggctggtgaacatcatgccc	12	7	9	13	1	2	2	2	1	0	1	2	2	2	2	3	2	5	3	3	2	5	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:44085423C>T	uc001cjr.2	+	29	5345	c.5005C>T	c.(5005-5007)CGG>TGG	p.R1669W	PTPRF_uc001cjs.2_Missense_Mutation_p.R1660W|PTPRF_uc001cju.2_Missense_Mutation_p.R1058W|PTPRF_uc009vwt.2_Missense_Mutation_p.R1229W|PTPRF_uc001cjv.2_Missense_Mutation_p.R1140W|PTPRF_uc001cjw.2_Missense_Mutation_p.R895W	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1669	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GTTCAAGAACCGGCTGGTGAA	0.582													12	65					0	0	0	0	T	44085423	T	T	44085423	3	4	149	1	0	0	0	0	1	0	0	0	12866	643	23	1	5111	1	PTPRF	1	44085423	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	3245588	44085423	205165198	4	27235											
ST6GALNAC3	256435	broad.mit.edu	37	chr1	76877873	76877873	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgagttgtgtcccataccAgcgttcctcttttgctaaaa	8	15	7	11	2	1	0	0	0	1	0	4	1	3	0	3	0	3	3	3	0	3	7			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:76877873A>G	uc001dhh.2	+	3	557	c.394A>G	c.(394-396)AGC>GGC	p.S132G	ST6GALNAC3_uc001dhg.3_Missense_Mutation_p.S132G|ST6GALNAC3_uc010orh.1_Missense_Mutation_p.S67G	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	132	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						GTCCCATACCAGCGTTCCTCT	0.428													23	69					0	0	0	0	G	76877873	G	G	76877873	3	3	149	1	0	0	0	0	1	0	0	0	15291	188	7	5	404	5	ST6GALNAC3	1	76877873	Missense_Mutation	SNP	A	TCGA-CR-7380-01A-11D-2012-08	32792450	76877873	172372748	5	27236											
NEXN	91624	broad.mit.edu	37	chr1	78392266	78392266	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaacaacgaccatctctCaaggaagcaaagtgtctttc	15	8	8	10	1	3	1	1	0	2	1	5	4	3	2	1	1	3	1	1	1	6	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:78392266C>G	uc001dic.3	+	7	954	c.657C>G	c.(655-657)CTC>CTG	p.L219L	NEXN_uc001dia.3_Silent_p.L205L|NEXN_uc009wcb.1_Silent_p.L141L|NEXN_uc001dib.3_Silent_p.L155L|NEXN_uc001did.1_Silent_p.L129L|NEXN_uc001dif.1_Silent_p.L111L	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	219	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		GACCATCTCTCAAGGAAGCAA	0.313													22	61					0	0	0	0	G	78392266	G	G	78392266	2	3	149	1	0	0	0	0	0	0	0	1	10409	813	29	2		2	NEXN	1	78392266	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08	1514393	78392266	170858355	6	27237											
ABCA4	24	broad.mit.edu	37	chr1	94543340	94543340	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcgtcagcctggctttccCgagggcccttgtagaggaag	6	10	14	11	2	1	1	1	0	0	1	3	3	2	2	3	3	1	2	3	3	2	3	rs145614671		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:94543340C>T	uc001dqh.2	-	11	1564	c.1460G>A	c.(1459-1461)CGG>CAG	p.R487Q	ABCA4_uc010otn.1_Missense_Mutation_p.R487Q	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	487	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CTGGCTTTCCCGAGGGCCCTT	0.502													55	122					0	0	0	0	T	94543340	T	T	94543340	3	4	149	1	0	0	0	0	1	0	0	0	34	652	23	1	5521	1	ABCA4	1	94543340	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	16151074	94543340	154707281	7	27238											
PRPF38B	55119	broad.mit.edu	37	chr1	109242023	109242023	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaggcatagaagtcgcagtcGaagtcgtgataggaaagggg	14	6	16	5	3	0	2	0	1	0	1	3	4	0	3	0	4	0	2	0	4	6	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:109242023G>A	uc001dvv.3	+	6	1304	c.1022G>A	c.(1021-1023)CGA>CAA	p.R341Q	PRPF38B_uc001dvw.3_Missense_Mutation_p.R230Q|PRPF38B_uc010ouz.1_Missense_Mutation_p.R144Q	NM_018061	NP_060531	Q5VTL8	PR38B_HUMAN	PRP38 pre-mRNA processing factor 38 (yeast)	341	Arg-rich.				mRNA processing|RNA splicing	spliceosomal complex					0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		AGTCGCAGTCGAAGTCGTGAT	0.328													22	42					0	0	0	0	A	109242023	A	A	109242023	3	1	149	1	0	0	0	0	1	0	0	0	12630	1058	37	1	1044	1	PRPF38B	1	109242023	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	14698683	109242023	140008598	8	27239											
TNN	63923	broad.mit.edu	37	chr1	175048747	175048747	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcatgtcggaggactgcagcGagaagcgctgtcccggcgac	8	6	15	12	5	1	1	1	0	0	1	3	5	2	3	1	3	3	2	1	3	1	0			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:175048747G>A	uc001gkl.1	+	3	801	c.688G>A	c.(688-690)GAG>AAG	p.E230K	TNN_uc010pmx.1_Missense_Mutation_p.E230K	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	230	EGF-like 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGACTGCAGCGAGAAGCGCTG	0.677													6	4					0	0	0	0	A	175048747	A	A	175048747	3	1	149	1	0	0	0	0	1	0	0	0	16389	1059	37	1	694	1	TNN	1	175048747	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	65806724	175048747	74201874	9	27240											
DENND1B	163486	broad.mit.edu	37	chr1	197482029	197482029	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttcaatgtcatcatcatCttcatcatcatatagagcac	12	15	3	11	0	9	1	7	0	2	1	9	1	9	1	0	0	1	1	0	0	3	4			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:197482029C>T	uc010ppe.1	-	20	1848	c.1510G>A	c.(1510-1512)GAT>AAT	p.D504N	DENND1B_uc010ppf.1_RNA	NM_001142795	NP_001136267	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 1	Error:Variant_position_missing_in_Q6P3S1_after_alignment						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						TCATCATCATCTTCATCATCA	0.373													7	36					0	0	0	0	T	197482029	T	T	197482029	3	4	149	1	0	0	0	0	1	0	0	0	4449	913	32	2	769	2	DENND1B	1	197482029	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	22433282	197482029	51768592	10	27241											
MOSC2	54996	broad.mit.edu	37	chr1	220955133	220955133	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttcagctaccgcctgtgtGatccttctgagagggaattg	7	13	12	9	1	2	2	1	2	1	1	3	4	3	3	3	1	2	2	3	1	2	4			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:220955133G>A	uc001hmq.2	+	7	1096	c.898G>A	c.(898-900)GAT>AAT	p.D300N	MOSC2_uc001hmr.2_Missense_Mutation_p.D300N|MOSC2_uc009xdx.2_Intron	NM_017898	NP_060368	Q969Z3	MOSC2_HUMAN	MOCO sulphurase C-terminal domain containing 2	300	MOSC.					mitochondrial outer membrane|peroxisome	molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding				0				GBM - Glioblastoma multiforme(131;0.00499)|all cancers(67;0.204)		CCGCCTGTGTGATCCTTCTGA	0.393													18	88					0	0	0	0	A	220955133	A	A	220955133	3	1	149	1	0	0	0	0	1	0	0	0	9767	1290	45	2	924	2	MOSC2	1	220955133	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	23473104	220955133	28295488	11	27242											
ZNF670	93474	broad.mit.edu	37	chr1	247201303	247201303	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgaagataacttgaataattGaaggctttatcacaatgttt	15	14	7	5	1	1	3	1	2	0	1	1	4	1	3	0	1	1	2	0	1	7	7			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr1:247201303G>A	uc001icd.1	-	4	789	c.618C>T	c.(616-618)TTC>TTT	p.F206F	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	206	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			TTGAATAATTGAAGGCTTTAT	0.343													5	40					0	0	0	0	A	247201303	A	A	247201303	2	1	149	1	0	0	0	0	0	0	0	1	18144	1281	45	2		2	ZNF670	1	247201303	Silent	SNP	G	TCGA-CR-7380-01A-11D-2012-08	26246170	247201303	2049318	12	27243											
SDC1	6382	broad.mit.edu	37	chr2	20405159	20405160	+	Frame_Shift_Ins	INS	-	G	G																															cagagccatcttgatcttcaINSgggggcaaattagtagccac																										TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:20405159_20405160insG	uc002rdo.1	-	2	391_392	c.92_93insC	c.(91-93)CCTfs	p.P31fs	SDC1_uc002rdp.1_Frame_Shift_Ins_p.P31fs|SDC1_uc010exv.2_Frame_Shift_Ins_p.P31fs|SDC1_uc010exw.1_RNA	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	31	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)|skin(1)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		CTTGATCTTCAGGGGGCAAATT	0.55													---	---	---								G	20405160	G	G	20405159	7	5	149	1	0	1	1	0	0	0	0	0	14016	175	7	0	855	0	SDC1	2	20405159	Frame_Shift_Ins	INS	-	TCGA-CR-7380-01A-11D-2012-08		20405159	222794214	13	27244											
C2orf16	84226	broad.mit.edu	37	chr2	27800115	27800115	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcttaggattaactccaGagaaaagctaccaaatccta	17	10	5	9	0	1	1	0	0	1	1	3	3	3	2	3	1	3	1	3	1	8	5			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:27800115G>T	uc002rkz.3	+	1	727	c.676G>T	c.(676-678)GAG>TAG	p.E226*		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	226										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					ATTAACTCCAGAGAAAAGCTA	0.448													22	48					6.33239e-15	8.11697e-15	1	0	T	27800115	T	T	27800115	4	4	149	1	0	0	0	0	0	1	0	0	2167	943	33	2	678	2	C2orf16	2	27800115	Nonsense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	7394956	27800115	215399258	14	27245											
PRKD3	23683	broad.mit.edu	37	chr2	37543567	37543567	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagtcgggcagagagtcccGtcttaggacttgaacacgga	11	7	14	9	3	1	3	0	1	1	2	3	6	2	5	1	3	1	1	1	3	2	2	rs114047527		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:37543567G>A	uc002rqd.2	-	1	656	c.101C>T	c.(100-102)ACG>ATG	p.T34M	PRKD3_uc002rqf.1_Missense_Mutation_p.T34M	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	34					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				AGAGAGTCCCGTCTTAGGACT	0.493													26	56					0	0	0	0	A	37543567	A	A	37543567	3	1	149	1	0	0	0	0	1	0	0	0	12582	1145	40	1	2643	1	PRKD3	2	37543567	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	9743452	37543567	205655806	15	27246											
GPR75	10936	broad.mit.edu	37	chr2	54081573	54081573	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggatactactggctgagctGaagaataacacaaaggtgaa	16	7	12	6	0	0	4	0	3	0	1	0	5	0	5	0	3	4	2	0	3	7	3			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:54081573G>A	uc002rxo.3	-	2	592	c.321C>T	c.(319-321)TTC>TTT	p.F107F	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	107	Helical; Name=2; (Potential).|Phe-rich.					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TGGCTGAGCTGAAGAATAACA	0.468													4	72					0	0	0	0	A	54081573	A	A	54081573	2	1	149	1	0	0	0	0	0	0	0	1	6746	1281	45	2		2	GPR75	2	54081573	Silent	SNP	G	TCGA-CR-7380-01A-11D-2012-08	16538006	54081573	189117800	16	27247											
SPTBN1	6711	broad.mit.edu	37	chr2	54753667	54753667	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatgagaacagctctgcgCggctttttgagcggtcccgc	8	9	12	12	4	1	2	0	2	1	1	2	3	2	2	1	2	4	2	1	2	2	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:54753667C>T	uc002rxu.2	+	2	361	c.112C>T	c.(112-114)CGG>TGG	p.R38W	SPTBN1_uc002rxv.1_Missense_Mutation_p.R38W|RPL23AP32_uc010yot.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	38	Actin-binding.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CAGCTCTGCGCGGCTTTTTGA	0.527													13	64					0	0	0	0	T	54753667	T	T	54753667	3	4	149	1	0	0	0	0	1	0	0	0	15185	759	27	1	114	1	SPTBN1	2	54753667	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	672094	54753667	188445706	17	27248											
SLC5A7	60482	broad.mit.edu	37	chr2	108625031	108625031	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtatatttctttctttGgtcttggtgcagtttctgct	3	22	9	7	0	4	0	0	0	4	0	4	0	4	0	0	2	2	4	0	2	2	7			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:108625031G>T	uc002tdv.2	+	8	1282	c.1006G>T	c.(1006-1008)GGT>TGT	p.G336C	SLC5A7_uc010ywm.1_Missense_Mutation_p.G89C|SLC5A7_uc010fjj.2_Missense_Mutation_p.G336C|SLC5A7_uc010ywn.1_Missense_Mutation_p.G223C	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	336	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TTCTTTCTTTGGTCTTGGTGC	0.443													18	25					2.94398e-08	3.64124e-08	1	0	T	108625031	T	T	108625031	3	4	149	1	0	0	0	0	1	0	0	0	14734	1348	47	4	1032	4	SLC5A7	2	108625031	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	53871364	108625031	134574342	18	27249											
GPR39	2863	broad.mit.edu	37	chr2	133174856	133174856	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtttggcttgctcggacatcTtggtgttcctcatcggcatg	4	15	12	10	2	2	0	1	0	1	0	5	1	3	1	1	4	1	5	1	4	0	4			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:133174856T>C	uc002ttl.2	+	1	710	c.241T>C	c.(241-243)TTG>CTG	p.L81L		NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	81	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						CTCGGACATCTTGGTGTTCCT	0.547													3	113					0	0	0	0	C	133174856	C	C	133174856	2	2	149	1	0	0	0	0	0	0	0	1	6731	1606	56	5		5	GPR39	2	133174856	Silent	SNP	T	TCGA-CR-7380-01A-11D-2012-08	24549825	133174856	110024517	19	27250											
LY75	4065	broad.mit.edu	37	chr2	160690588	160690588	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagtatgaacttcatcctGtgttgttgccatatgcctat	8	18	7	8	0	1	1	1	1	0	0	2	1	2	1	3	0	3	3	3	0	5	8			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:160690588G>A	uc002ubc.3	-	27	3877	c.3808C>T	c.(3808-3810)CAG>TAG	p.Q1270*	LY75_uc002ubb.3_Nonsense_Mutation_p.Q1270*|LY75_uc010fos.2_Nonsense_Mutation_p.Q1270*	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1270	Extracellular (Potential).|C-type lectin 8.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		ACTTCATCCTGTGTTGTTGCC	0.249													16	32					0	0	0	0	A	160690588	A	A	160690588	4	1	149	1	0	0	0	0	0	1	0	0	9150	1386	48	4	1396	4	LY75	2	160690588	Nonsense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	27515732	160690588	82508785	20	27251											
LY75	4065	broad.mit.edu	37	chr2	160708798	160708799	+	Frame_Shift_Ins	INS	-	T	T																															tctaacgaagaaacattataINStttttcacagatgaagggca																										TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:160708798_160708799insT	uc002ubc.3	-	21	2865_2866	c.2796_2797insA	c.(2794-2799)AAATATfs	p.K932fs	LY75_uc002ubb.3_Frame_Shift_Ins_p.K932fs|LY75_uc010fos.2_Frame_Shift_Ins_p.K932fs	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	932_933	Extracellular (Potential).				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		GAAACATTATATTTTTCACAGA	0.366													---	---	---								T	160708799	T	T	160708798	7	5	149	1	0	1	1	0	0	0	0	0	9150	449	16	0	2431	0	LY75	2	160708798	Frame_Shift_Ins	INS	-	TCGA-CR-7380-01A-11D-2012-08	18210	160708798	82490575	21	27252											
XIRP2	129446	broad.mit.edu	37	chr2	168107151	168107151	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagaaaacagtacagcaccaAgtagcagctcatcatgaagc	17	5	9	10	0	2	2	2	1	0	1	2	3	2	2	1	0	6	5	1	0	6	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:168107151A>T	uc002udx.2	+	8	9267	c.9249A>T	c.(9247-9249)CAA>CAT	p.Q3083H	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.Q2908H|XIRP2_uc010fpq.2_Missense_Mutation_p.Q2861H|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2908					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TACAGCACCAAGTAGCAGCTC	0.353													23	29					0	0	0	0	T	168107151	T	T	168107151	3	4	149	1	0	0	0	0	1	0	0	0	17498	69	3	5	9279	5	XIRP2	2	168107151	Missense_Mutation	SNP	A	TCGA-CR-7380-01A-11D-2012-08	7398353	168107151	75092222	22	27253											
WIPF1	7456	broad.mit.edu	37	chr2	175446145	175446145	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcctgctctgtcttattcAaggtaggcttctctgtattg	6	16	9	10	0	4	0	1	0	3	0	5	0	4	0	1	2	2	4	1	2	4	6			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:175446145A>C	uc002uiy.2	-	4	406	c.74T>G	c.(73-75)TTG>TGG	p.L25W	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.L25W|WIPF1_uc010fqt.1_Missense_Mutation_p.L25W|WIPF1_uc002ujc.1_Missense_Mutation_p.L25W|WIPF1_uc002uiz.2_Missense_Mutation_p.L25W|WIPF1_uc002ujb.1_Missense_Mutation_p.L25W|WIPF1_uc010zep.1_Missense_Mutation_p.L25W	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	25					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						TGTCTTATTCAAGGTAGGCTT	0.443													45	156					0	0	0	0	C	175446145	C	C	175446145	3	2	149	1	0	0	0	0	1	0	0	0	17435	131	5	5	1461	5	WIPF1	2	175446145	Missense_Mutation	SNP	A	TCGA-CR-7380-01A-11D-2012-08	7338994	175446145	67753228	23	27254											
TTN	7273	broad.mit.edu	37	chr2	179400029	179400029	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgaaggctctgaaggcttGctcagaccaaatttattttc	10	14	8	9	0	3	3	1	2	2	1	4	3	3	3	1	2	1	3	1	2	4	5			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:179400029G>T	uc010zfg.1	-	307	93833	c.93609C>A	c.(93607-93609)AGC>AGA	p.S31203R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S24898R|TTN_uc010zfi.1_Missense_Mutation_p.S24831R|TTN_uc010zfj.1_Missense_Mutation_p.S24706R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32130							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAAGGCTTGCTCAGACCAA	0.423													42	66					6.45866e-13	8.20424e-13	1	0	T	179400029	T	T	179400029	3	4	149	1	0	0	0	0	1	0	0	0	16803	1310	46	4	6686	4	TTN	2	179400029	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	3953884	179400029	63799344	24	27255											
TTN	7273	broad.mit.edu	37	chr2	179596116	179596116	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcccatcatgcttgacttCaatgccactgaggtacaaac	11	12	6	12	0	2	2	2	2	0	0	3	2	3	2	2	1	4	2	2	1	3	4			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:179596116C>T	uc010zfg.1	-	56	13869	c.13645G>A	c.(13645-13647)GAA>AAA	p.E4549K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E1210K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5476							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTTGACTTCAATGCCACTG	0.403													9	175					0	0	0	0	T	179596116	T	T	179596116	3	4	149	1	0	0	0	0	1	0	0	0	16803	835	29	2	87368	2	TTN	2	179596116	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	196087	179596116	63603257	25	27256											
COL3A1	1281	broad.mit.edu	37	chr2	189857641	189857641	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggtcctcctggaactgccgGattccctggatcccctggtg	4	11	12	14	1	0	0	0	0	0	0	4	3	4	3	6	5	2	0	6	5	1	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:189857641G>T	uc002uqj.1	+	15	1142	c.1025G>T	c.(1024-1026)GGA>GTA	p.G342V	COL3A1_uc010frw.1_RNA	NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	342	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGAACTGCCGGATTCCCTGGA	0.393													37	37					8.16277e-20	1.05592e-19	1	0	T	189857641	T	T	189857641	3	4	149	1	0	0	0	0	1	0	0	0	3703	1174	41	2	1083	2	COL3A1	2	189857641	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	10261525	189857641	53341732	26	27257											
CPS1	1373	broad.mit.edu	37	chr2	211471497	211471497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgcccagacactctccaatgCcgagtttcagatgttgagac	10	10	9	12	1	2	3	1	1	1	3	3	5	2	3	3	0	2	2	3	0	1	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:211471497C>T	uc002vee.3	+	18	2156	c.2024C>T	c.(2023-2025)GCC>GTC	p.A675V	CPS1_uc010fur.2_Missense_Mutation_p.A681V|CPS1_uc010fus.2_Missense_Mutation_p.A224V	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	675	ATP-grasp 1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CTCTCCAATGCCGAGTTTCAG	0.453													19	20					0	0	0	0	T	211471497	T	T	211471497	3	4	149	1	0	0	0	0	1	0	0	0	3838	739	26	4	2116	4	CPS1	2	211471497	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	21613856	211471497	31727876	27	27258											
OBSL1	23363	broad.mit.edu	37	chr2	220422982	220422982	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcgtcctcaggctgggcGtggggcagggtcagggtgcg	3	6	21	11	4	2	0	2	0	0	0	3	0	3	0	2	7	1	2	2	7	0	0			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr2:220422982G>A	uc010fwk.2	-	10	3483	c.3426C>T	c.(3424-3426)CAC>CAT	p.H1142H	OBSL1_uc002vmh.1_Silent_p.H133H|OBSL1_uc010zli.1_Intron|OBSL1_uc010fwl.1_Silent_p.H617H	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1142	Ig-like 9.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CAGGCTGGGCGTGGGGCAGGG	0.667													11	7					0	0	0	0	A	220422982	A	A	220422982	2	1	149	1	0	0	0	0	0	0	0	1	10867	1136	40	1		1	OBSL1	2	220422982	Silent	SNP	G	TCGA-CR-7380-01A-11D-2012-08	8951485	220422982	22776391	28	27259											
DOCK3	1795	broad.mit.edu	37	chr3	51349911	51349911	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctctgtctgtctaggtgtGgaattcttactttagcctgg	5	18	10	8	0	4	0	0	0	4	0	5	1	4	1	1	3	2	0	1	3	4	6			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr3:51349911G>T	uc011bds.1	+	30	3121	c.3098G>T	c.(3097-3099)TGG>TTG	p.W1033L		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1033						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GTCTAGGTGTGGAATTCTTAC	0.373													3	38					0.004672	0.00544423	1	0	T	51349911	T	T	51349911	3	4	149	1	0	0	0	0	1	0	0	0	4710	1357	47	4	3216	4	DOCK3	3	51349911	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08		51349911	146672519	29	27260											
NAALADL2	254827	broad.mit.edu	37	chr3	174974310	174974310	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaattaggaaaattgccactGctttataaggttggtccagt	13	13	9	6	0	0	0	0	0	0	0	1	1	1	1	2	3	2	2	2	3	6	6			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr3:174974310G>A	uc003fit.2	+	4	1017	c.930G>A	c.(928-930)CTG>CTA	p.L310L	NAALADL2_uc003fiu.1_Silent_p.L303L|NAALADL2_uc010hwy.1_Silent_p.L132L|NAALADL2_uc010hwz.1_5'UTR	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	310	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		AATTGCCACTGCTTTATAAGG	0.358													4	40					0	0	0	0	A	174974310	A	A	174974310	2	1	149	1	0	0	0	0	0	0	0	1	10183	1306	46	4		4	NAALADL2	3	174974310	Silent	SNP	G	TCGA-CR-7380-01A-11D-2012-08	123624399	174974310	23048120	30	27261											
C4orf23	152992	broad.mit.edu	37	chr4	8456493	8456493	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcagagggattgatgtcCgaagaagaaaaatctgggac	15	6	14	6	1	1	4	0	1	1	3	2	7	2	6	1	3	0	1	1	3	4	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr4:8456493C>T	uc003glg.1	+	6	657	c.469C>T	c.(469-471)CGA>TGA	p.R157*	C4orf23_uc003glf.1_Nonsense_Mutation_p.R145*|C4orf23_uc003glh.1_5'UTR	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	386					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						GATTGATGTCCGAAGAAGAAA	0.393													29	68					0	0	0	0	T	8456493	T	T	8456493	4	4	149	1	0	0	0	0	0	1	0	0	2266	644	23	1	1178	1	C4orf23	4	8456493	Nonsense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08		8456493	182697783	31	27262											
DNAH5	1767	broad.mit.edu	37	chr5	13919309	13919309	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagtttcgacttggccgcCgcaagcactgccagcacagc	9	6	11	15	3	0	0	0	0	0	0	1	1	0	0	3	1	5	5	3	1	1	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr5:13919309C>T	uc003jfd.2	-	7	993	c.951G>A	c.(949-951)GCG>GCA	p.A317A	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	317	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACTTGGCCGCCGCAAGCACTG	0.463									Kartagener_syndrome				42	104					0	0	0	0	T	13919309	T	T	13919309	2	4	149	1	0	0	0	0	0	0	0	1	4626	639	23	1		1	DNAH5	5	13919309	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08		13919309	166995951	32	27263											
SLC1A3	6507	broad.mit.edu	37	chr5	36608588	36608591	+	Frame_Shift_Del	DEL	AGTC	-	-																															atggagagattccagcagggAgtccgtaaacgcacactttt																										TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr5:36608588_36608591delAGTC	uc003jkj.3	+	2	539_542	c.63_66delAGTC	c.(61-66)GGAGTCfs	p.G21fs	SLC1A3_uc011cox.1_5'UTR|SLC1A3_uc010iuy.2_Frame_Shift_Del_p.G21fs	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	21_22	Cytoplasmic (Potential).				D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TCCAGCAGGGAGTCCGTAAACGCA	0.446													---	---	---								-	36608591	-	-	36608588	7	5	149	1	0	1	0	1	0	0	0	0	14498	291	11	0	65	0	SLC1A3	5	36608588	Frame_Shift_Del	DEL	AGTC	TCGA-CR-7380-01A-11D-2012-08	22689279	36608588	144306672	33	27264											
AFF4	27125	broad.mit.edu	37	chr5	132232472	132232472	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taggtcgaggggaagacttaGactccttctttatattgggt	9	14	12	6	1	1	2	0	0	1	2	3	4	2	3	1	4	0	0	1	4	5	7			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr5:132232472G>C	uc003kyd.2	-	11	2258	c.1850C>G	c.(1849-1851)TCT>TGT	p.S617C	AFF4_uc011cxk.1_Missense_Mutation_p.S295C|AFF4_uc003kye.1_Missense_Mutation_p.S617C	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	617					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGAAGACTTAGACTCCTTCTT	0.433													36	26					0	0	0	0	C	132232472	C	C	132232472	3	2	149	1	0	0	0	0	1	0	0	0	359	942	33	2	1685	2	AFF4	5	132232472	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	95623884	132232472	48682788	34	27265											
SLC25A2	83884	broad.mit.edu	37	chr5	140683343	140683343	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcttcacttttattgtgtcGaagggctgcccagtcagtac	8	14	9	10	1	3	0	2	0	1	0	4	1	3	0	1	1	2	2	1	1	3	5			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr5:140683343G>A	uc003ljf.2	-	1	270	c.90C>T	c.(88-90)TTC>TTT	p.F30F		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	30	Solcar 1.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TTATTGTGTCGAAGGGCTGCC	0.597													8	71					0	0	0	0	A	140683343	A	A	140683343	2	1	149	1	0	0	0	0	0	0	0	1	14546	1049	37	1		1	SLC25A2	5	140683343	Silent	SNP	G	TCGA-CR-7380-01A-11D-2012-08	8450871	140683343	40231917	35	27266											
MFAP3	4238	broad.mit.edu	37	chr5	153432559	153432559	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtgggctctatacctgtttCgtcacctctccaattcgtgc	5	14	8	14	3	3	0	1	0	2	0	6	0	3	0	3	1	2	2	3	1	3	4			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr5:153432559C>T	uc003lvf.2	+	3	891	c.375C>T	c.(373-375)TTC>TTT	p.F125F	MFAP3_uc010jib.2_Silent_p.F125F|MFAP3_uc011ddb.1_5'UTR	NM_001135037	NP_001128509	P55082	MFAP3_HUMAN	microfibrillar-associated protein 3 isoform 2	125	Ig-like C2-type.|Extracellular (Potential).					integral to membrane|plasma membrane					0	Renal(175;0.00488)	Lung NSC(249;0.00145)|all_lung(500;0.00226)|all_neural(177;0.122)|Breast(839;0.14)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;9.69e-06)|GBM - Glioblastoma multiforme(465;0.0201)		ATACCTGTTTCGTCACCTCTC	0.438													44	44					0	0	0	0	T	153432559	T	T	153432559	2	4	149	1	0	0	0	0	0	0	0	1	9568	883	31	1		1	MFAP3	5	153432559	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08	12749216	153432559	27482701	36	27267											
NHP2	55651	broad.mit.edu	37	chr5	177577981	177577981	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatgggcagtgtgtctcctgCcaaaaccatgatcctgaaat	12	10	9	10	0	1	2	0	2	1	0	3	2	2	2	4	1	2	1	4	1	4	0			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr5:177577981C>A	uc003mir.2	-	3	387	c.244G>T	c.(244-246)GCA>TCA	p.A82S	NHP2_uc003mis.2_Intron	NM_017838	NP_060308	Q9NX24	NHP2_HUMAN	nucleolar protein family A, member 2 isoform a	82					rRNA pseudouridine synthesis	Cajal body|nucleolus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding				0						GTGTCTCCTGCCAAAACCATG	0.483													16	137					2.32078e-09	2.89585e-09	1	0	A	177577981	A	A	177577981	3	1	149	1	0	0	0	0	1	0	0	0	10463	739	26	4	225	4	NHP2	5	177577981	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	24145422	177577981	3337279	37	27268											
NEDD9	4739	broad.mit.edu	37	chr6	11191251	11191251	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaccggttctgcagctcctGgaatgtcacagttgtatttt	7	14	9	11	1	2	0	1	0	1	0	3	1	3	1	3	2	2	5	3	2	2	5			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr6:11191251G>T	uc003mzv.2	-	5	1018	c.851C>A	c.(850-852)CCA>CAA	p.P284Q	NEDD9_uc010joz.2_Missense_Mutation_p.P284Q|NEDD9_uc003mzw.3_Missense_Mutation_p.P138Q	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	284					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			TGCAGCTCCTGGAATGTCACA	0.577													12	51					4.3838e-07	5.28304e-07	1	0	T	11191251	T	T	11191251	3	4	149	1	0	0	0	0	1	0	0	0	10367	1348	47	4	1665	4	NEDD9	6	11191251	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08		11191251	159923816	38	27269											
DCDC2	51473	broad.mit.edu	37	chr6	24302242	24302242	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttctaaagcgagctgacaCgttgatcctgctatggatta	10	14	9	8	2	1	2	0	2	1	0	2	4	2	3	1	1	3	3	1	1	4	6			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr6:24302242C>T	uc003ndx.2	-	3	681	c.379G>A	c.(379-381)GTG>ATG	p.V127M	DCDC2_uc003ndy.2_Missense_Mutation_p.V127M	NM_016356	NP_057440	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	127					cellular defense response|intracellular signal transduction|neuron migration					ovary(1)	1		Ovarian(999;0.101)				CGAGCTGACACGTTGATCCTG	0.353													22	43					0	0	0	0	T	24302242	T	T	24302242	3	4	149	1	0	0	0	0	1	0	0	0	4302	536	19	1	1083	1	DCDC2	6	24302242	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	13110991	24302242	146812825	39	27270											
DDR1	780	broad.mit.edu	37	chr6	30856982	30856982	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccctcttcaccctcaggttGgagagcagtgacggggatgg	7	8	14	12	1	3	2	2	1	1	1	3	4	3	3	3	5	1	2	3	5	0	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr6:30856982G>A	uc003nrr.2	+	5	451	c.192G>A	c.(190-192)TTG>TTA	p.L64L	DDR1_uc010jse.2_Silent_p.L64L|DDR1_uc003nrq.2_Silent_p.L64L|DDR1_uc003nrs.2_Silent_p.L64L|DDR1_uc003nrt.2_Silent_p.L64L|DDR1_uc011dms.1_Silent_p.L82L|DDR1_uc011dmt.1_Silent_p.L90L|DDR1_uc003nru.2_Silent_p.L64L|DDR1_uc011dmu.1_Silent_p.L64L|DDR1_uc003nrv.2_Silent_p.L64L|DDR1_uc003nrw.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	64	Extracellular (Potential).|F5/8 type C.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	CCCTCAGGTTGGAGAGCAGTG	0.602													65	137					0	0	0	0	A	30856982	A	A	30856982	2	1	149	1	0	0	0	0	0	0	0	1	4353	1339	47	4		4	DDR1	6	30856982	Silent	SNP	G	TCGA-CR-7380-01A-11D-2012-08	6554740	30856982	140258085	40	27271											
OOEP	441161	broad.mit.edu	37	chr6	74078519	74078519	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttgtcttaagcaacaggAtcctggggagagtgggggtc	9	10	16	6	0	1	1	0	0	1	1	3	3	2	2	1	5	2	2	1	5	2	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr6:74078519A>T	uc003pgu.3	-	3	438	c.438T>A	c.(436-438)GAT>GAA	p.D146E	OOEP_uc003pgv.3_Missense_Mutation_p.D91E	NM_001080507	NP_001073976	A6NGQ2	OOEP_HUMAN	oocyte expressed protein homolog	146						cytoplasm					0						AAGCAACAGGATCCTGGGGAG	0.423													4	45					0	0	0	0	T	74078519	T	T	74078519	3	4	149	1	0	0	0	0	1	0	0	0	10924	330	12	5	15	5	OOEP	6	74078519	Missense_Mutation	SNP	A	TCGA-CR-7380-01A-11D-2012-08	43221537	74078519	97036548	41	27272											
RAET1E	135250	broad.mit.edu	37	chr6	150209677	150209677	+	Frame_Shift_Del	DEL	T	-	-																															gaccagcctgccactcaccaTtttgccaccagacacagatg																										TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr6:150209677delT	uc003qnl.1	-	4	809	c.749delA	c.(748-750)AATfs	p.N250fs	uc003qni.1_Intron|RAET1E_uc003qnj.2_Intron|RAET1E_uc003qnk.1_Frame_Shift_Del_p.N214fs|RAET1E_uc010kih.1_RNA	NM_139165	NP_631904	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E precursor	250	Cytoplasmic (Potential).				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		CCACTCACCATTTTGCCACCA	0.507													---	---	---								-	150209677	-	-	150209677	7	5	149	1	0	1	0	1	0	0	0	0	13064	1493	52	0	46	0	RAET1E	6	150209677	Frame_Shift_Del	DEL	T	TCGA-CR-7380-01A-11D-2012-08	76131158	150209677	20905390	42	27273											
CARD11	84433	broad.mit.edu	37	chr7	2954903	2954903	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcaagagcttggtggcgTccagcgaggaccgggccagg	8	5	17	11	3	1	1	1	0	0	1	2	3	2	2	3	5	2	1	3	5	1	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr7:2954903T>C	uc003smv.2	-	21	3211	c.2807A>G	c.(2806-2808)GAC>GGC	p.D936G		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	936					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CTTGGTGGCGTCCAGCGAGGA	0.627			Mis		DLBCL								3	171					0	0	0	0	C	2954903	C	C	2954903	3	2	149	1	0	0	0	0	1	0	0	0	2657	1667	58	5	677	5	CARD11	7	2954903	Missense_Mutation	SNP	T	TCGA-CR-7380-01A-11D-2012-08		2954903	156183760	43	27274											
STK31	56164	broad.mit.edu	37	chr7	23825153	23825153	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcttcttgatgctgagccCatgaaggaacttagcagcaa	12	10	10	9	0	2	3	0	3	2	0	2	5	2	4	1	1	5	3	1	1	4	3			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr7:23825153C>T	uc003sws.3	+	18	2272	c.2205C>T	c.(2203-2205)CCC>CCT	p.P735P	STK31_uc003swt.3_Silent_p.P712P|STK31_uc011jze.1_Silent_p.P735P|STK31_uc010kuq.2_Silent_p.P712P|STK31_uc003swv.1_5'Flank	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	735	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						ATGCTGAGCCCATGAAGGAAC	0.423													33	140					0	0	0	0	T	23825153	T	T	23825153	2	4	149	1	0	0	0	0	0	0	0	1	15362	581	21	4		4	STK31	7	23825153	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08	20870250	23825153	135313510	44	27275											
SFRP4	6424	broad.mit.edu	37	chr7	37955724	37955724	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtccgtgacgatggcttcaGgcgagatgcacacgccacgg	8	6	15	12	5	1	2	1	1	0	1	2	4	2	2	2	4	1	2	2	4	0	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr7:37955724G>T	uc003tfo.3	-	1	802	c.416C>A	c.(415-417)CCT>CAT	p.P139H		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	139	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						GATGGCTTCAGGCGAGATGCA	0.652													71	59					1.7488e-33	2.30449e-33	1	0	T	37955724	T	T	37955724	3	4	149	1	0	0	0	0	1	0	0	0	14228	1000	35	4	648	4	SFRP4	7	37955724	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	14130571	37955724	121182939	45	27276											
TYW1	55253	broad.mit.edu	37	chr7	66703464	66703465	+	Frame_Shift_Ins	INS	-	G	G																															gaaagaggctttgatcccaaINSggacacaagacatcagagaa																										TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr7:66703464_66703465insG	uc003tvn.2	+	16	2296_2297	c.2147_2148insG	c.(2146-2148)AAGfs	p.K716fs	TYW1_uc010lai.2_RNA|TYW1_uc011kef.1_Frame_Shift_Ins_p.K330fs|PMS2L4_uc003tvo.2_Intron	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	716					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				TTTGATCCCAAGGACACAAGAC	0.421													---	---	---								G	66703465	G	G	66703464	7	5	149	1	0	1	1	0	0	0	0	0	16886	72	3	0	2209	0	TYW1	7	66703464	Frame_Shift_Ins	INS	-	TCGA-CR-7380-01A-11D-2012-08	28747740	66703464	92435199	46	27277											
LEP	3952	broad.mit.edu	37	chr7	127894691	127894691	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggccagtggcctggagAccttggacagcctggggggt	5	7	18	11	0	0	1	0	0	0	1	0	3	0	2	5	7	1	0	5	7	0	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr7:127894691A>G	uc003vml.2	+	3	436	c.379A>G	c.(379-381)ACC>GCC	p.T127A	LEP_uc003vmm.2_Missense_Mutation_p.T126A	NM_000230	NP_000221	P41159	LEP_HUMAN	leptin precursor	127					adult feeding behavior|energy reserve metabolic process|negative regulation of appetite|placenta development|positive regulation of developmental growth	extracellular space					0						TGGCCTGGAGACCTTGGACAG	0.607													11	36					0	0	0	0	G	127894691	G	G	127894691	3	3	149	1	0	0	0	0	1	0	0	0	8767	275	10	5	385	5	LEP	7	127894691	Missense_Mutation	SNP	A	TCGA-CR-7380-01A-11D-2012-08	61191227	127894691	31243972	47	27278											
NRF1	4899	broad.mit.edu	37	chr7	129297406	129297406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggtgacagctcatctggCagctgcaggtagtgttgttt	7	13	14	7	0	2	2	1	2	1	0	2	2	2	2	0	3	3	7	0	3	1	3			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr7:129297406C>T	uc003voz.2	+	2	332	c.215C>T	c.(214-216)GCA>GTA	p.A72V	NRF1_uc003vpa.2_Missense_Mutation_p.A72V|NRF1_uc011kpa.1_5'UTR|NRF1_uc003vpb.2_Missense_Mutation_p.A72V	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	72	Dimerization.				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GCTCATCTGGCAGCTGCAGGT	0.338													14	33					0	0	0	0	T	129297406	T	T	129297406	3	4	149	1	0	0	0	0	1	0	0	0	10700	710	25	4	217	4	NRF1	7	129297406	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	1402715	129297406	29841257	48	27279											
EPHA1	2041	broad.mit.edu	37	chr7	143098584	143098584	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgcgggaagcctcctcccCgcggtagatccaattggagc	8	6	13	14	4	0	1	0	0	0	1	3	4	3	3	5	3	2	1	5	3	3	2	rs144146635		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr7:143098584C>T	uc003wcz.2	-	3	352	c.265G>A	c.(265-267)GGG>AGG	p.G89R		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	89	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GCCTCCTCCCCGCGGTAGATC	0.607													82	112					0	0	0	0	T	143098584	T	T	143098584	3	4	149	1	0	0	0	0	1	0	0	0	5189	652	23	1	2729	1	EPHA1	7	143098584	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	13801178	143098584	16040079	49	27280											
ZNF212	7988	broad.mit.edu	37	chr7	148947811	148947811	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgatggcgtctgtttcaccGagcaggaatgggagaatctg	10	10	14	7	2	3	2	1	1	2	1	3	5	3	3	1	3	1	2	1	3	2	1	rs145118937	by1000genomes	TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr7:148947811G>A	uc003wfp.2	+	3	550	c.454G>A	c.(454-456)GAG>AAG	p.E152K		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	152	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			CTGTTTCACCGAGCAGGAATG	0.498													58	75					0	0	0	0	A	148947811	A	A	148947811	3	1	149	1	0	0	0	0	1	0	0	0	17835	1059	37	1	464	1	ZNF212	7	148947811	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	5849227	148947811	10190852	50	27281											
KCNH2	3757	broad.mit.edu	37	chr7	150649889	150649889	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggatggtccagcggtggatgCgcggtgcctgcagcttgtac	5	9	17	10	3	0	0	0	0	0	0	1	2	1	2	2	5	6	3	2	5	1	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr7:150649889C>T	uc003wic.2	-	6	1194	c.1181G>A	c.(1180-1182)CGC>CAC	p.R394H	KCNH2_uc003wib.2_Missense_Mutation_p.R54H|KCNH2_uc011kux.1_Missense_Mutation_p.R298H|KCNH2_uc003wid.2_Missense_Mutation_p.R54H|KCNH2_uc003wie.2_Missense_Mutation_p.R394H	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	394	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GCGGTGGATGCGCGGTGCCTG	0.647													7	82					0	0	0	0	T	150649889	T	T	150649889	3	4	149	1	0	0	0	0	1	0	0	0	8071	768	27	1	2607	1	KCNH2	7	150649889	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	1702078	150649889	8488774	51	27282											
NOM1	64434	broad.mit.edu	37	chr7	156762310	156762310	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaagaacgcacaggcccaCagaagcgccgacgaagccaa	16	1	10	14	4	0	2	0	0	0	2	0	4	0	2	3	1	3	1	3	1	6	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr7:156762310C>T	uc003wmy.2	+	11	2511	c.2496C>T	c.(2494-2496)CAC>CAT	p.H832H		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	832					RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		CACAGGCCCACAGAAGCGCCG	0.507													33	94					0	0	0	0	T	156762310	T	T	156762310	2	4	149	1	0	0	0	0	0	0	0	1	10584	477	17	4		4	NOM1	7	156762310	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08	6112421	156762310	2376353	52	27283											
CHD7	55636	broad.mit.edu	37	chr8	61707620	61707620	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaacagaaggttctgaaaaTtcagacttagacaaaacacc	20	7	6	8	0	2	4	1	1	1	3	2	4	2	4	1	1	2	1	1	1	8	3			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr8:61707620T>A	uc003xue.2	+	4	2649	c.2172T>A	c.(2170-2172)AAT>AAA	p.N724K		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	724					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GTTCTGAAAATTCAGACTTAG	0.418													40	89					0	0	0	0	A	61707620	A	A	61707620	3	1	149	1	0	0	0	0	1	0	0	0	3345	1490	52	5	2182	5	CHD7	8	61707620	Missense_Mutation	SNP	T	TCGA-CR-7380-01A-11D-2012-08		61707620	84656402	53	27284											
TERF1	7013	broad.mit.edu	37	chr8	73921257	73921257	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgaatgccaggaactgctcGagtgccaggtgcaggtgggg	8	7	17	9	2	0	0	0	0	0	0	2	3	0	1	2	5	5	2	2	5	2	0			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr8:73921257G>A	uc003xzd.2	+	1	161	c.136G>A	c.(136-138)GAG>AAG	p.E46K	TERF1_uc003xzc.2_RNA|TERF1_uc003xze.2_Missense_Mutation_p.E46K	NM_017489	NP_059523	P54274	TERF1_HUMAN	telomeric repeat binding factor 1 isoform 1	46	Asp/Glu-rich (acidic).				age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			ovary(1)|lung(1)|skin(1)	3	Breast(64;0.218)		Epithelial(68;0.0984)			GGAACTGCTCGAGTGCCAGGT	0.587													4	49					0	0	0	0	A	73921257	A	A	73921257	3	1	149	1	0	0	0	0	1	0	0	0	15827	1059	37	1	138	1	TERF1	8	73921257	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	12213637	73921257	72442765	54	27285											
SLC26A7	115111	broad.mit.edu	37	chr8	92365190	92365191	+	Frame_Shift_Ins	INS	-	A	A																															ctaatacagttccgagatttINSaaaaaaatattggaatgtgg																										TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr8:92365190_92365191insA	uc003yex.2	+	12	1558_1559	c.1280_1281insA	c.(1279-1281)TTAfs	p.L427fs	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Frame_Shift_Ins_p.L427fs|SLC26A7_uc003yfa.2_Frame_Shift_Ins_p.L427fs	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	427	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TTCCGAGATTTAAAAAAATATT	0.327													---	---	---								A	92365191	A	A	92365190	7	5	149	1	0	1	1	0	0	0	0	0	14586	1764	61	0	1318	0	SLC26A7	8	92365190	Frame_Shift_Ins	INS	-	TCGA-CR-7380-01A-11D-2012-08	18443933	92365190	53998832	55	27286											
VPS13B	157680	broad.mit.edu	37	chr8	100147902	100147902	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaattcattgtttgattacCgaagcccagaaaataatggt	15	12	7	7	1	1	2	1	1	0	1	1	3	1	2	2	1	2	1	2	1	6	5			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr8:100147902C>T	uc003yiv.2	+	11	1615	c.1504C>T	c.(1504-1506)CGA>TGA	p.R502*	VPS13B_uc003yiw.2_Nonsense_Mutation_p.R502*|VPS13B_uc003yit.2_Nonsense_Mutation_p.R502*|VPS13B_uc003yiu.1_Nonsense_Mutation_p.R502*|VPS13B_uc003yix.1_5'Flank	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	502					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GTTTGATTACCGAAGCCCAGA	0.338													16	37					0	0	0	0	T	100147902	T	T	100147902	4	4	149	1	0	0	0	0	0	1	0	0	17258	644	23	1	1584	1	VPS13B	8	100147902	Nonsense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	7782712	100147902	46216120	56	27287											
COL22A1	169044	broad.mit.edu	37	chr8	139890008	139890008	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcactttcacaaagacggcGccgcagcttgccccggatct	8	8	9	16	4	3	1	2	0	1	1	3	2	3	2	3	2	2	2	3	2	1	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr8:139890008G>A	uc003yvd.2	-	3	1090	c.643C>T	c.(643-645)CGC>TGC	p.R215C		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	215					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CAAAGACGGCGCCGCAGCTTG	0.662										HNSCC(7;0.00092)			17	30					0	0	0	0	A	139890008	A	A	139890008	3	1	149	1	0	0	0	0	1	0	0	0	3696	1087	38	1	4489	1	COL22A1	8	139890008	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	39742106	139890008	6474014	57	27288											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			16	7					0	0	0	0	A	21971120	A	A	21971120	4	1	149	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08		21971120	119242311	58	27289											
ELAVL2	1993	broad.mit.edu	37	chr9	23692607	23692607	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agacctgcagtactctgtctCccagacggtatccattgagg	9	10	10	12	1	2	3	0	1	2	2	4	3	3	3	3	2	2	3	3	2	2	3			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr9:23692607C>T	uc003zpu.2	-	7	1303	c.1028G>A	c.(1027-1029)GGA>GAA	p.G343E	ELAVL2_uc003zps.2_Missense_Mutation_p.G330E|ELAVL2_uc003zpt.2_Missense_Mutation_p.G330E|ELAVL2_uc003zpv.2_Missense_Mutation_p.G343E|ELAVL2_uc003zpw.2_Missense_Mutation_p.G330E	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	343	RRM 3.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TACTCTGTCTCCCAGACGGTA	0.408													18	25					0	0	0	0	T	23692607	T	T	23692607	3	4	149	1	0	0	0	0	1	0	0	0	5074	855	30	2	55	2	ELAVL2	9	23692607	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	1721487	23692607	117520824	59	27290											
TAF1L	138474	broad.mit.edu	37	chr9	32635310	32635310	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatttaccaaggcaccgcCagtcccagtcaattcttcat	11	11	5	14	1	4	0	3	0	1	0	5	0	5	0	4	1	1	1	4	1	3	4			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr9:32635310C>T	uc003zrg.1	-	1	358	c.268G>A	c.(268-270)GGC>AGC	p.G90S	uc003zrh.1_Intron	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	90					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AAGGCACCGCCAGTCCCAGTC	0.488													67	139					0	0	0	0	T	32635310	T	T	32635310	3	4	149	1	0	0	0	0	1	0	0	0	15589	594	21	4	5216	4	TAF1L	9	32635310	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	8942703	32635310	108578121	60	27291											
NPR2	4882	broad.mit.edu	37	chr9	35799694	35799694	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgtctgctgataagagcccGggaagactttggtgtggagc	8	10	15	8	2	1	3	0	1	1	2	2	5	1	5	1	3	3	1	1	3	2	2	rs144940095		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr9:35799694G>A	uc003zyd.2	+	3	953	c.953G>A	c.(952-954)CGG>CAG	p.R318Q	NPR2_uc010mlb.2_Missense_Mutation_p.R318Q	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	318	Extracellular (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	ATAAGAGCCCGGGAAGACTTT	0.527													10	87					0	0	0	0	A	35799694	A	A	35799694	3	1	149	1	0	0	0	0	1	0	0	0	10649	1116	39	1	963	1	NPR2	9	35799694	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	3164384	35799694	105413737	61	27292											
DAB2IP	153090	broad.mit.edu	37	chr9	124522454	124522454	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacctgctgcctcggtggcCgggcggcagttcgtggagaa	5	8	16	12	4	0	1	0	0	0	1	2	2	0	1	3	5	3	3	3	5	2	2	rs140379738		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr9:124522454C>T	uc004bln.2	+	6	891	c.822C>T	c.(820-822)GCC>GCT	p.A274A	DAB2IP_uc004blo.2_Silent_p.A178A	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	302					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						CCTCGGTGGCCGGGCGGCAGT	0.637													9	75					0	0	0	0	T	124522454	T	T	124522454	2	4	149	1	0	0	0	0	0	0	0	1	4236	639	23	1		1	DAB2IP	9	124522454	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08	88722760	124522454	16690977	62	27293											
PKN3	29941	broad.mit.edu	37	chr9	131476379	131476379	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccggctgcagaggcaggaaCgcatcttctctaaacgcaga	11	6	11	13	3	2	2	0	0	2	2	3	3	2	3	1	3	3	5	1	3	3	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr9:131476379C>T	uc004bvw.2	+	10	1684	c.1291C>T	c.(1291-1293)CGC>TGC	p.R431C	PKN3_uc010myh.2_Missense_Mutation_p.R431C|PKN3_uc011mbk.1_Translation_Start_Site	NM_013355	NP_037487	Q6P5Z2	PKN3_HUMAN	protein kinase PKNbeta	431					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			stomach(2)|lung(2)	4						GAGGCAGGAACGCATCTTCTC	0.627													28	99					0	0	0	0	T	131476379	T	T	131476379	3	4	149	1	0	0	0	0	1	0	0	0	12036	536	19	1	1329	1	PKN3	9	131476379	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	6953925	131476379	9737052	63	27294											
LRRC8A	56262	broad.mit.edu	37	chr9	131678559	131678559	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgagtgcccactgctcaagcGcagcggcttggtggtggagg	6	7	17	11	3	1	0	1	0	0	0	1	2	1	1	1	5	4	3	1	5	1	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr9:131678559G>A	uc004bwl.3	+	4	2596	c.2342G>A	c.(2341-2343)CGC>CAC	p.R781H	LRRC8A_uc010myp.2_Missense_Mutation_p.R781H|LRRC8A_uc010myq.2_Missense_Mutation_p.R781H	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	781					pre-B cell differentiation	integral to membrane					0						CTGCTCAAGCGCAGCGGCTTG	0.672													20	38					0	0	0	0	A	131678559	A	A	131678559	3	1	149	1	0	0	0	0	1	0	0	0	9071	1087	38	1	2348	1	LRRC8A	9	131678559	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	202180	131678559	9534872	64	27295											
PHYHD1	254295	broad.mit.edu	37	chr9	131696086	131696086	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagactatttcttgagcaGtggtgacaagattcgattct	11	13	9	8	1	2	4	0	2	2	2	3	5	2	4	0	1	1	1	0	1	2	5			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr9:131696086G>T	uc004bwo.2	+	5	1151	c.218G>T	c.(217-219)AGT>ATT	p.S73I	PHYHD1_uc004bwn.2_Missense_Mutation_p.S73I|PHYHD1_uc004bwm.2_RNA|PHYHD1_uc004bwp.2_Missense_Mutation_p.S73I	NM_001100876	NP_001094346	Q5SRE7	PHYD1_HUMAN	phytanoyl-CoA dioxygenase domain containing 1	73							metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TTCTTGAGCAGTGGTGACAAG	0.552											OREG0003917	type=REGULATORY REGION|Gene=AK130919|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	64	91					5.10652e-33	6.66685e-33	1	0	T	131696086	T	T	131696086	3	4	149	1	0	0	0	0	1	0	0	0	11920	1029	36	4	228	4	PHYHD1	9	131696086	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	17527	131696086	9517345	65	27296											
NOTCH1	4851	broad.mit.edu	37	chr9	139405168	139405168	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagccggcctggcagtggcAgcggtagccgccgtgggtgt	4	7	19	11	4	0	0	0	0	0	0	0	0	0	0	4	5	3	4	4	5	2	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr9:139405168A>T	uc004chz.2	-	17	2677	c.2677T>A	c.(2677-2679)TGC>AGC	p.C893S	NOTCH1_uc004cia.1_Missense_Mutation_p.C123S	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	893	Extracellular (Potential).|EGF-like 23; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TGGCAGTGGCAGCGGTAGCCG	0.692			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			13	26					0	0	0	0	T	139405168	T	T	139405168	3	4	149	1	0	0	0	0	1	0	0	0	10601	188	7	5	5062	5	NOTCH1	9	139405168	Missense_Mutation	SNP	A	TCGA-CR-7380-01A-11D-2012-08	7709082	139405168	1808263	66	27297											
ITGB1	3688	broad.mit.edu	37	chr10	33217097	33217097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actttttacattctccaaatCgtctttcattgagtaagaca	12	16	4	9	1	3	2	1	1	2	1	5	2	3	2	1	0	1	1	1	0	3	7			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr10:33217097C>T	uc001iws.3	-	5	608	c.472G>A	c.(472-474)GAT>AAT	p.D158N	ITGB1_uc001iwp.3_Missense_Mutation_p.D158N|ITGB1_uc001iwq.3_Missense_Mutation_p.D158N|ITGB1_uc001iwr.3_Missense_Mutation_p.D158N|ITGB1_uc001iwt.3_Missense_Mutation_p.D158N|ITGB1_uc001iwu.1_Missense_Mutation_p.D158N	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	158	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TTCTCCAAATCGTCTTTCATT	0.373													18	61					0	0	0	0	T	33217097	T	T	33217097	3	4	149	1	0	0	0	0	1	0	0	0	7929	884	31	1	2210	1	ITGB1	10	33217097	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08		33217097	102317650	67	27298											
TSPAN15	23555	broad.mit.edu	37	chr10	71258083	71258083	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgagattggagcaagaatcaGtaccacgactgcagtgcccc	12	6	11	12	2	1	2	1	0	0	2	1	5	1	3	3	1	4	3	3	1	3	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr10:71258083G>A	uc001jpo.1	+	5	626	c.501G>A	c.(499-501)CAG>CAA	p.Q167Q		NM_012339	NP_036471	O95858	TSN15_HUMAN	transmembrane 4 superfamily member 15	167	Extracellular (Potential).					integral to plasma membrane|membrane fraction					0						GCAAGAATCAGTACCACGACT	0.627													18	27					0	0	0	0	A	71258083	A	A	71258083	2	1	149	1	0	0	0	0	0	0	0	1	16706	1020	36	4		4	TSPAN15	10	71258083	Silent	SNP	G	TCGA-CR-7380-01A-11D-2012-08	38040986	71258083	64276664	68	27299											
SORCS1	114815	broad.mit.edu	37	chr10	108389025	108389025	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccacctgcacggtcacaCggaaaatgcccacgttctga	10	8	9	14	3	2	1	1	1	1	0	3	2	3	2	3	2	2	2	3	2	2	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr10:108389025C>T	uc001kym.2	-	19	2605	c.2597G>A	c.(2596-2598)CGT>CAT	p.R866H	SORCS1_uc001kyl.2_Missense_Mutation_p.R866H|SORCS1_uc009xxs.2_Missense_Mutation_p.R866H|SORCS1_uc001kyn.1_Missense_Mutation_p.R866H|SORCS1_uc001kyo.2_Missense_Mutation_p.R866H	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	866	Lumenal (Potential).|PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CACGGTCACACGGAAAATGCC	0.473													9	24					0	0	0	0	T	108389025	T	T	108389025	3	4	149	1	0	0	0	0	1	0	0	0	14994	536	19	1	1175	1	SORCS1	10	108389025	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	37130942	108389025	27145722	69	27300											
GALNTL4	374378	broad.mit.edu	37	chr11	11394162	11394163	+	Frame_Shift_Ins	INS	-	T	T																															gtccacaatgaagcagccaaINStgagggcagggctcctgcag																										TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr11:11394162_11394163insT	uc001mjo.2	-	6	1412_1413	c.991_992insA	c.(991-993)ATTfs	p.I331fs		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	331	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		GAAGCAGCCAATGAGGGCAGGG	0.604													---	---	---								T	11394163	T	T	11394162	7	5	149	1	0	1	1	0	0	0	0	0	6258	101	4	0	855	0	GALNTL4	11	11394162	Frame_Shift_Ins	INS	-	TCGA-CR-7380-01A-11D-2012-08		11394162	123612354	70	27301											
SLC22A11	55867	broad.mit.edu	37	chr11	64337279	64337279	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttgtgctgttcttcctccCggagacccagggacttccgc	4	11	12	14	2	1	1	0	0	1	1	4	3	4	2	4	3	1	3	4	3	0	4			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr11:64337279C>T	uc001oai.2	+	9	1912	c.1538C>T	c.(1537-1539)CCG>CTG	p.P513L	SLC22A11_uc001oaj.2_Intron|SLC22A11_uc009ypq.2_Missense_Mutation_p.P405L	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	513	Cytoplasmic (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	TTCTTCCTCCCGGAGACCCAG	0.627													32	89					0	0	0	0	T	64337279	T	T	64337279	3	4	149	1	0	0	0	0	1	0	0	0	14507	652	23	1	1572	1	SLC22A11	11	64337279	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	52943117	64337279	70669237	71	27302											
KIAA1377	57562	broad.mit.edu	37	chr11	101818768	101818768	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tattatctctttagtttcccGaaaaccagttcctccattag	10	16	4	11	1	1	0	0	0	1	0	5	1	4	0	4	0	1	2	4	0	6	7			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr11:101818768G>A	uc001pgm.2	+	4	671	c.401G>A	c.(400-402)CGA>CAA	p.R134Q	KIAA1377_uc001pgn.2_Missense_Mutation_p.R90Q|KIAA1377_uc009yxa.1_5'UTR	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	134							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TTAGTTTCCCGAAAACCAGTT	0.333													11	15					0	0	0	0	A	101818768	A	A	101818768	3	1	149	1	0	0	0	0	1	0	0	0	8266	1058	37	1	415	1	KIAA1377	11	101818768	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	37481489	101818768	33187748	72	27303											
ATM	472	broad.mit.edu	37	chr11	108117798	108117798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaagtattcttcaggatttCgtaatattgccgtcaaagaa	14	13	8	6	2	3	1	2	0	1	1	4	3	3	2	1	1	1	2	1	1	6	7	rs138398778		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr11:108117798C>T	uc001pkb.1	+	8	1394	c.1009C>T	c.(1009-1011)CGT>TGT	p.R337C	ATM_uc009yxr.1_Missense_Mutation_p.R337C	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	337			R -> C (in a colorectal adenocarcinoma sample; somatic mutation).|R -> H (in a colorectal adenocarcinoma sample; somatic mutation).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.R337C(2)|p.R337S(2)|p.R337H(1)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTCAGGATTTCGTAATATTGC	0.323			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			17	5					0	0	0	0	T	108117798	T	T	108117798	3	4	149	1	0	0	0	0	1	0	0	0	1111	884	31	1	1035	1	ATM	11	108117798	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	6299030	108117798	26888718	73	27304											
KDM5A	5927	broad.mit.edu	37	chr12	475139	475139	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaaaagctcatatgggtaGagaattctttcataatgtga	14	13	10	4	0	3	2	2	1	1	1	3	4	3	3	0	2	1	2	0	2	6	5			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr12:475139G>C	uc001qif.1	-	4	861	c.498C>G	c.(496-498)CTC>CTG	p.L166L	KDM5A_uc001qie.1_Silent_p.L166L|KDM5A_uc010sdn.1_Silent_p.L125L|KDM5A_uc010sdo.1_Intron	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	166	ARID.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						CATATGGGTAGAGAATTCTTT	0.393			T 	NUP98	AML								8	224					0	0	0	0	C	475139	C	C	475139	2	2	149	1	0	0	0	0	0	0	0	1	8172	929	33	2		2	KDM5A	12	475139	Silent	SNP	G	TCGA-CR-7380-01A-11D-2012-08		475139	133376756	74	27305											
OR6C74	254783	broad.mit.edu	37	chr12	55641374	55641375	+	Frame_Shift_Del	DEL	CA	-	-																															tgtgcagcacagctgtttttCactattctcttgggggcaac																										TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr12:55641374_55641375delCA	uc010spg.1	+	1	303_304	c.303_304delCA	c.(301-306)TTCACTfs	p.F101fs		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	101_102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AGCTGTTTTTCACTATTCTCTT	0.436													---	---	---								-	55641375	-	-	55641374	7	5	149	1	0	1	0	1	0	0	0	0	11252	825	29	0	305	0	OR6C74	12	55641374	Frame_Shift_Del	DEL	CA	TCGA-CR-7380-01A-11D-2012-08	55166235	55641374	78210521	75	27306											
TMCC3	57458	broad.mit.edu	37	chr12	94965489	94965489	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagctccagcttagaaatgcGagtctggcaggattccaagg	11	8	13	9	1	1	1	0	0	1	1	3	4	3	2	2	3	3	3	2	3	3	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr12:94965489G>A	uc001tdj.2	-	4	1274	c.1156C>T	c.(1156-1158)CGC>TGC	p.R386C	TMCC3_uc001tdi.2_Missense_Mutation_p.R355C	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	386	Potential.					integral to membrane				ovary(1)|skin(1)	2						TTAGAAATGCGAGTCTGGCAG	0.547													30	62					0	0	0	0	A	94965489	A	A	94965489	3	1	149	1	0	0	0	0	1	0	0	0	16060	1058	37	1	281	1	TMCC3	12	94965489	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	39324115	94965489	38886406	76	27307											
SLC5A8	160728	broad.mit.edu	37	chr12	101551086	101551086	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcccattgctcttgccacTctgatctgagttcaattcaa	9	14	6	12	0	5	2	2	2	3	0	6	2	6	2	2	0	2	2	2	0	2	4			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr12:101551086T>C	uc001thz.3	-	15	2194	c.1804A>G	c.(1804-1806)AGT>GGT	p.S602G		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	602	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						CTCTTGCCACTCTGATCTGAG	0.368													4	37					0	0	0	0	C	101551086	C	C	101551086	3	2	149	1	0	0	0	0	1	0	0	0	14735	1551	54	5	32	5	SLC5A8	12	101551086	Missense_Mutation	SNP	T	TCGA-CR-7380-01A-11D-2012-08	6585597	101551086	32300809	77	27308											
CUX2	23316	broad.mit.edu	37	chr12	111785858	111785858	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctggaggtgtcactgaactCgccctcggccgcctcctcac	5	8	10	18	3	2	1	2	1	0	0	5	2	3	2	5	3	1	0	5	3	1	0			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr12:111785858C>T	uc001tsa.1	+	22	4343	c.4190C>T	c.(4189-4191)TCG>TTG	p.S1397L		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1397	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TCACTGAACTCGCCCTCGGCC	0.637													30	55					0	0	0	0	T	111785858	T	T	111785858	3	4	149	1	0	0	0	0	1	0	0	0	4082	893	31	1	4276	1	CUX2	12	111785858	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	10234772	111785858	22066037	78	27309											
SUDS3	64426	broad.mit.edu	37	chr12	118829084	118829084	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgacaatggaactgactGgaggtaggaaagccctatgg	13	7	14	7	0	0	2	0	2	0	0	0	5	0	5	1	5	3	2	1	5	5	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr12:118829084G>A	uc001twz.2	+	6	653	c.514G>A	c.(514-516)GGA>AGA	p.G172R		NM_022491	NP_071936	Q9H7L9	SDS3_HUMAN	suppressor of defective silencing 3	172					chromatin modification|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	Sin3 complex	histone deacetylase binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGAACTGACTGGAGGTAGGAA	0.463													16	110					0	0	0	0	A	118829084	A	A	118829084	3	1	149	1	0	0	0	0	1	0	0	0	15433	1349	47	4	536	4	SUDS3	12	118829084	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	7043226	118829084	15022811	79	27310											
HIP1R	9026	broad.mit.edu	37	chr12	123340573	123340573	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccaggtgaatgcactggAgggtgagctggaggagcagc	10	5	19	7	0	0	2	0	2	0	0	0	6	0	5	1	5	5	3	1	5	1	0			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr12:123340573A>G	uc001udj.1	+	14	1234	c.1175A>G	c.(1174-1176)GAG>GGG	p.E392G	HIP1R_uc001udg.1_Missense_Mutation_p.E380G|HIP1R_uc001udi.1_Missense_Mutation_p.E392G|HIP1R_uc001udk.1_5'UTR	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	392	Potential.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		AATGCACTGGAGGGTGAGCTG	0.682													6	6					0	0	0	0	G	123340573	G	G	123340573	3	3	149	1	0	0	0	0	1	0	0	0	7154	304	11	5	1229	5	HIP1R	12	123340573	Missense_Mutation	SNP	A	TCGA-CR-7380-01A-11D-2012-08	4511489	123340573	10511322	80	27311											
FRY	10129	broad.mit.edu	37	chr13	32805362	32805362	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacatcacacctaaaaatCaaaattcaaagagtgctgaa	21	7	5	8	0	3	3	3	1	0	2	3	3	3	3	1	0	1	1	1	0	8	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr13:32805362C>A	uc001utx.2	+	41	5948	c.5452C>A	c.(5452-5454)CAA>AAA	p.Q1818K	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1818					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACCTAAAAATCAAAATTCAAA	0.333													17	42					1.5739e-10	1.98142e-10	1	0	A	32805362	A	A	32805362	3	1	149	1	0	0	0	0	1	0	0	0	6097	827	29	2	5614	2	FRY	13	32805362	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08		32805362	82364516	81	27312											
SMAD9	4093	broad.mit.edu	37	chr13	37439827	37439827	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggaatgtctccccaactcGgttgttcagttcatagtagg	8	13	10	10	1	3	0	2	0	1	0	5	1	3	1	2	3	1	4	2	3	4	5			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr13:37439827G>A	uc001uvw.2	-	5	1193	c.850C>T	c.(850-852)CGA>TGA	p.R284*	SMAD9_uc001uvx.2_Nonsense_Mutation_p.R247*|SMAD9_uc010tep.1_Nonsense_Mutation_p.R77*	NM_001127217	NP_001120689	O15198	SMAD9_HUMAN	SMAD family member 9 isoform a	284	MH2.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		TCCCCAACTCGGTTGTTCAGT	0.498													11	32					0	0	0	0	A	37439827	A	A	37439827	4	1	149	1	0	0	0	0	0	1	0	0	14828	1124	39	1	565	1	SMAD9	13	37439827	Nonsense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	4634465	37439827	77730051	82	27313											
TNFSF11	8600	broad.mit.edu	37	chr13	43180950	43180950	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttggtggattttttaagttaCggtctggagaggaaatcagc	10	14	13	4	1	2	1	1	0	1	1	2	4	2	3	0	5	2	1	0	5	3	5	rs150392469		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr13:43180950C>T	uc001uyu.2	+	5	999	c.850C>T	c.(850-852)CGG>TGG	p.R284W	TNFSF11_uc001uyt.2_Missense_Mutation_p.R211W	NM_003701	NP_003692	O14788	TNF11_HUMAN	tumor necrosis factor ligand superfamily, member	284	Extracellular (Potential).				immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding				0		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TTTTAAGTTACGGTCTGGAGA	0.423													19	82					0	0	0	0	T	43180950	T	T	43180950	3	4	149	1	0	0	0	0	1	0	0	0	16368	527	19	1	868	1	TNFSF11	13	43180950	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	5741123	43180950	71988928	83	27314											
PIBF1	10464	broad.mit.edu	37	chr13	73468075	73468076	+	Frame_Shift_Ins	INS	-	A	A																															tggaatgtgaaaaatatcagINSaaaaaattggaggtacatgt																										TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr13:73468075_73468076insA	uc001vjc.2	+	11	1781_1782	c.1476_1477insA	c.(1474-1479)CAGAAAfs	p.Q492fs	PIBF1_uc010aeo.1_RNA|PIBF1_uc001vjb.2_Frame_Shift_Ins_p.Q492fs|PIBF1_uc010aep.2_Intron	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	492_493						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		AAAAATATCAGAAAAAATTGGA	0.332													---	---	---								A	73468076	A	A	73468075	7	5	149	1	0	1	1	0	0	0	0	0	11934	933	33	0	1514	0	PIBF1	13	73468075	Frame_Shift_Ins	INS	-	TCGA-CR-7380-01A-11D-2012-08	30287125	73468075	41701803	84	27315											
MYO16	23026	broad.mit.edu	37	chr13	109661380	109661380	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggtaaccagaatggagttTtggacttttttttccaggta	9	16	10	6	0	0	1	0	0	0	1	1	3	1	3	2	4	1	3	2	4	3	8			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr13:109661380T>C	uc001vqt.1	+	22	2638	c.2512T>C	c.(2512-2514)TTG>CTG	p.L838L	MYO16_uc010agk.1_Silent_p.L860L|MYO16_uc001vqu.1_Silent_p.L638L|MYO16_uc010tjh.1_Silent_p.L350L	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	838					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GAATGGAGTTTTGGACTTTTT	0.358													21	54					0	0	0	0	C	109661380	C	C	109661380	2	2	149	1	0	0	0	0	0	0	0	1	10117	1838	64	5		5	MYO16	13	109661380	Silent	SNP	T	TCGA-CR-7380-01A-11D-2012-08	36193305	109661380	5508498	85	27316											
CDH24	64403	broad.mit.edu	37	chr14	23517613	23517613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtaggtgatgatgttctctCggacgtcctcctcctccagt	5	13	10	13	3	1	2	0	2	1	0	7	3	5	3	4	2	0	2	4	2	1	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr14:23517613C>T	uc001wil.2	-	13	2296	c.2036G>A	c.(2035-2037)CGA>CAA	p.R679Q	CDH24_uc001wik.3_RNA|CDH24_uc010akf.2_Missense_Mutation_p.R641Q	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	679	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GATGTTCTCTCGGACGTCCTC	0.602													8	201					0	0	0	0	T	23517613	T	T	23517613	3	4	149	1	0	0	0	0	1	0	0	0	3124	884	31	1	427	1	CDH24	14	23517613	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08		23517613	83831927	86	27317											
SERPINA1	5265	broad.mit.edu	37	chr14	94849078	94849078	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccccgaagttgacagtgaagGcttctgagtggtacaacttt	10	11	11	9	1	1	3	0	3	1	0	1	4	1	3	2	2	2	3	2	2	4	4	rs142942004		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr14:94849078G>A	uc001ycx.3	-	2	758	c.497C>T	c.(496-498)GCC>GTC	p.A166V	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Missense_Mutation_p.A166V|SERPINA1_uc010aux.2_Missense_Mutation_p.A166V|SERPINA1_uc001ycy.3_Missense_Mutation_p.A166V|SERPINA1_uc010auy.2_Missense_Mutation_p.A166V|SERPINA1_uc001ycz.3_Missense_Mutation_p.A166V|SERPINA1_uc010auz.2_Missense_Mutation_p.A166V|SERPINA1_uc010ava.2_Missense_Mutation_p.A166V|SERPINA1_uc001ydb.3_Missense_Mutation_p.A166V|SERPINA1_uc010avb.2_Missense_Mutation_p.A166V|SERPINA1_uc001ydc.3_Missense_Mutation_p.A166V|SERPINA1_uc001yda.1_Missense_Mutation_p.A166V	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	166					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	GACAGTGAAGGCTTCTGAGTG	0.498									Alpha-1-Antitrypsin_Deficiency				80	99					0	0	0	0	A	94849078	A	A	94849078	3	1	149	1	0	0	0	0	1	0	0	0	14151	1203	42	4	775	4	SERPINA1	14	94849078	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	71331465	94849078	12500462	87	27318											
DLL4	54567	broad.mit.edu	37	chr15	41228839	41228839	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcatggtggcagtggctGtgcggcagctgcggcttcga	4	9	19	9	3	0	0	0	0	0	0	1	1	0	0	0	6	3	6	0	6	0	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr15:41228839G>A	uc001zng.1	+	9	1974	c.1654G>A	c.(1654-1656)GTG>ATG	p.V552M		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	552	Cytoplasmic (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GGCAGTGGCTGTGCGGCAGCT	0.667													12	23					0	0	0	0	A	41228839	A	A	41228839	3	1	149	1	0	0	0	0	1	0	0	0	4590	1377	48	4	1688	4	DLL4	15	41228839	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08		41228839	61302553	88	27319											
HERC1	8925	broad.mit.edu	37	chr15	63958585	63958585	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catggctttggcaatctgccGaagagagaaccccatttcca	11	9	9	12	1	1	2	0	0	1	2	2	4	2	2	4	2	2	2	4	2	3	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr15:63958585G>A	uc002amp.2	-	41	8441	c.8293C>T	c.(8293-8295)CGG>TGG	p.R2765W		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2765					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GCAATCTGCCGAAGAGAGAAC	0.428													23	75					0	0	0	0	A	63958585	A	A	63958585	3	1	149	1	0	0	0	0	1	0	0	0	7096	1057	37	1	6444	1	HERC1	15	63958585	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	22729746	63958585	38572807	89	27320											
AXIN1	8312	broad.mit.edu	37	chr16	396963	396963	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcaccaggcactgggggtcgGggagcatcttcggtgaaact	8	8	15	10	2	2	1	1	1	1	0	4	2	2	2	1	6	2	2	1	6	1	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr16:396963G>A	uc002cgp.1	-	2	240	c.63C>T	c.(61-63)CCC>CCT	p.P21P	AXIN1_uc002cgq.1_Silent_p.P21P	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	21	Tankyrase-binding motif.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CTGGGGGTCGGGGAGCATCTT	0.572													25	55					0	0	0	0	A	396963	A	A	396963	2	1	149	1	0	0	0	0	0	0	0	1	1238	1219	43	4		4	AXIN1	16	396963	Silent	SNP	G	TCGA-CR-7380-01A-11D-2012-08		396963	89957790	90	27321											
TBL3	10607	broad.mit.edu	37	chr16	2024602	2024602	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctggcaagagggcagcgttAcccgcctgtggaaggcgata	9	6	15	11	3	0	1	0	0	0	1	0	3	0	2	3	4	2	3	3	4	4	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr16:2024602A>C	uc002cnu.1	+	5	403	c.301A>C	c.(301-303)ACC>CCC	p.T101P	TBL3_uc002cnv.1_5'UTR|TBL3_uc010bsb.1_5'UTR|TBL3_uc010bsc.1_5'UTR|TBL3_uc010uvt.1_5'Flank|TBL3_uc002cnw.1_5'Flank	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	101	WD 1.				G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0						GGGCAGCGTTACCCGCCTGTG	0.662													7	36					0	0	0	0	C	2024602	C	C	2024602	3	2	149	1	0	0	0	0	1	0	0	0	15709	391	14	5	319	5	TBL3	16	2024602	Missense_Mutation	SNP	A	TCGA-CR-7380-01A-11D-2012-08	1627639	2024602	88330151	91	27322											
MMP25	64386	broad.mit.edu	37	chr16	3100422	3100422	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgactttgcccgcgccttccAccaggacagctaccccttcg	6	8	8	19	4	0	0	0	0	0	0	2	2	1	1	6	1	3	1	6	1	1	4			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr16:3100422A>G	uc002cth.2	+	4	773	c.536A>G	c.(535-537)CAC>CGC	p.H179R	MMP25_uc002cti.1_Missense_Mutation_p.H115R	NM_022468	NP_071913	Q9NPA2	MMP25_HUMAN	matrix metalloproteinase 25 preproprotein	179					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0						CGCGCCTTCCACCAGGACAGC	0.632													23	60					0	0	0	0	G	3100422	G	G	3100422	3	3	149	1	0	0	0	0	1	0	0	0	9715	159	6	5	550	5	MMP25	16	3100422	Missense_Mutation	SNP	A	TCGA-CR-7380-01A-11D-2012-08	1075820	3100422	87254331	92	27323											
PDILT	204474	broad.mit.edu	37	chr16	20371929	20371929	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagttttgatgtggctttcCaggaagtcagagaagccctt	9	14	11	7	0	1	2	1	1	0	1	2	4	2	3	2	2	1	2	2	2	3	5			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr16:20371929C>T	uc002dhc.1	-	11	1690	c.1467G>A	c.(1465-1467)CTG>CTA	p.L489L		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	489					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TGTGGCTTTCCAGGAAGTCAG	0.468													65	150					0	0	0	0	T	20371929	T	T	20371929	2	4	149	1	0	0	0	0	0	0	0	1	11728	581	21	4		4	PDILT	16	20371929	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08	17271507	20371929	69982824	93	27324											
RPGRIP1L	23322	broad.mit.edu	37	chr16	53720433	53720433	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caactgagttttcaggatctCagccaagtgctctaactcct	10	12	7	12	0	3	1	2	1	2	0	5	2	4	2	2	1	4	2	2	1	3	3			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr16:53720433C>T	uc002ehp.2	-	6	752	c.688G>A	c.(688-690)GAG>AAG	p.E230K	RPGRIP1L_uc002eho.3_Missense_Mutation_p.E230K|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.E230K|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.E230K|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.E230K|RPGRIP1L_uc002ehq.1_Missense_Mutation_p.E230K	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	230	Potential.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TTCAGGATCTCAGCCAAGTGC	0.378													4	70					0	0	0	0	T	53720433	T	T	53720433	3	4	149	1	0	0	0	0	1	0	0	0	13615	835	29	2	3347	2	RPGRIP1L	16	53720433	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	33348504	53720433	36634320	94	27325											
CMTM4	146223	broad.mit.edu	37	chr16	66651242	66651242	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgattttttccttactgttaCgtttgtggagtaggaaaaac	10	17	9	5	1	0	1	0	1	0	0	1	3	1	3	1	2	3	3	1	2	5	7			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr16:66651242C>A	uc002epz.2	-	5	825	c.643G>T	c.(643-645)GTA>TTA	p.V215L	CMTM4_uc002eqa.2_3'UTR	NM_178818	NP_848933	Q8IZR5	CKLF4_HUMAN	chemokine-like factor superfamily 4 isoform 1	215					chemotaxis	extracellular space|integral to membrane	cytokine activity			pancreas(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0811)|Epithelial(162;0.214)		CTTACTGTTACGTTTGTGGAG	0.363													12	21					9.31168e-06	1.11267e-05	1	0	A	66651242	A	A	66651242	3	1	149	1	0	0	0	0	1	0	0	0	3600	536	19	3	65	3	CMTM4	16	66651242	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	12930809	66651242	23703511	95	27326											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	5	11	9	16	2	3	0	0	0	3	0	7	1	5	1	3	3	1	1	3	3	0	2	rs28934574		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	19					0	0	0	0	A	7577094	A	A	7577094	3	1	149	1	0	0	0	0	1	0	0	0	16448	1115	39	1	442	1	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08		7577094	73618116	96	27327											
ALOX15B	247	broad.mit.edu	37	chr17	7951079	7951079	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagtttgactcctgtgcttGgatgcccaacctgccaccca	7	11	8	15	0	1	1	1	1	0	0	2	2	2	2	5	1	4	2	5	1	1	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr17:7951079G>A	uc002gju.2	+	13	1813	c.1697G>A	c.(1696-1698)TGG>TAG	p.W566*	ALOX15B_uc002gjv.2_Nonsense_Mutation_p.W537*|ALOX15B_uc002gjw.2_Nonsense_Mutation_p.W492*|ALOX15B_uc010vun.1_Nonsense_Mutation_p.W554*|ALOX15B_uc010cnp.2_Nonsense_Mutation_p.W372*	NM_001141	NP_001132	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, second type	566	Lipoxygenase.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			ovary(1)	1						TCCTGTGCTTGGATGCCCAAC	0.632													17	56					0	0	0	0	A	7951079	A	A	7951079	4	1	149	1	0	0	0	0	0	1	0	0	539	1357	47	4	1747	4	ALOX15B	17	7951079	Nonsense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	373985	7951079	73244131	97	27328											
TOP3A	7156	broad.mit.edu	37	chr17	18198059	18198059	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caatcctcatggtttctttaGcatttattctcaactttcga	9	18	4	10	1	3	0	2	0	2	0	6	1	4	0	1	1	2	2	1	1	4	7			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr17:18198059G>A	uc002gsx.1	-	10	1260	c.1031C>T	c.(1030-1032)GCT>GTT	p.A344V	TOP3A_uc010vxr.1_5'UTR|TOP3A_uc002gsw.1_5'UTR|TOP3A_uc010vxs.1_Missense_Mutation_p.A242V	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	344					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						GGTTTCTTTAGCATTTATTCT	0.423													13	48					0	0	0	0	A	18198059	A	A	18198059	3	1	149	1	0	0	0	0	1	0	0	0	16434	971	34	4	2014	4	TOP3A	17	18198059	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	10246980	18198059	62997151	98	27329											
CACNB1	782	broad.mit.edu	37	chr17	37331582	37331584	+	In_Frame_Del	DEL	TCT	-	-																															cggtcagctcttcctcatagTcttcttcctcgtcctcccag																										TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr17:37331582_37331584delTCT	uc002hrm.1	-	14	1812_1814	c.1659_1661delAGA	c.(1657-1662)GAAGAC>GAC	p.E553del	CACNB1_uc002hrl.1_In_Frame_Del_p.E325del	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	553					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	TTCCTCATAGTCTTCTTCCTCGT	0.645											OREG0024371	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	37331584	-	-	37331582	7	5	149	1	0	1	0	1	0	0	0	0	2564	1667	58	0	139	0	CACNB1	17	37331582	In_Frame_Del	DEL	TCT	TCGA-CR-7380-01A-11D-2012-08	19133523	37331582	43863628	99	27330											
KRT36	8689	broad.mit.edu	37	chr17	39643859	39643859	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accaggcctccacatctctgCggttattctccaccagggcc	7	9	8	17	1	2	0	0	0	2	0	5	0	3	0	6	3	1	1	6	3	1	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr17:39643859C>T	uc002hwt.2	-	4	830	c.830G>A	c.(829-831)CGC>CAC	p.R277H		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	277	Rod.|Coil 2.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				CACATCTCTGCGGTTATTCTC	0.592													31	85					0	0	0	0	T	39643859	T	T	39643859	3	4	149	1	0	0	0	0	1	0	0	0	8512	768	27	1	589	1	KRT36	17	39643859	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	2312277	39643859	41551351	100	27331											
SLC38A10	124565	broad.mit.edu	37	chr17	79220126	79220126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcccccggcttccctggCggggtctggcacgggcacct	2	7	16	16	3	1	0	0	0	1	0	2	0	2	0	4	7	0	3	4	7	0	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr17:79220126C>T	uc002jzz.1	-	16	2965	c.2590G>A	c.(2590-2592)GCC>ACC	p.A864T	SLC38A10_uc002jzy.1_Missense_Mutation_p.A782T	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	864					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GCTTCCCTGGCGGGGTCTGGC	0.657													21	61					0	0	0	0	T	79220126	T	T	79220126	3	4	149	1	0	0	0	0	1	0	0	0	14666	768	27	1	773	1	SLC38A10	17	79220126	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	39576267	79220126	1975084	101	27332											
KDM4B	23030	broad.mit.edu	37	chr19	5151410	5151410	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggccaaggccgccaagcGcccgcgtgtgggcaccccgc	6	2	16	17	5	0	0	0	0	0	0	0	1	0	1	6	4	1	1	6	4	2	0			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr19:5151410G>A	uc002mbq.3	+	23	3405	c.3179G>A	c.(3178-3180)CGC>CAC	p.R1060H	KDM4B_uc010xim.1_Missense_Mutation_p.R1094H|KDM4B_uc002mbr.3_Missense_Mutation_p.R818H	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	1060					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						GCCGCCAAGCGCCCGCGTGTG	0.721													4	5					0	0	0	0	A	5151410	A	A	5151410	3	1	149	1	0	0	0	0	1	0	0	0	8168	1087	38	1	3261	1	KDM4B	19	5151410	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08		5151410	53977573	102	27333											
MUC16	94025	broad.mit.edu	37	chr19	9048094	9048094	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggtgaccaatgaagttgtGgtctctggttcatcagaaga	10	12	13	6	0	3	4	2	2	1	2	4	4	3	4	1	3	0	2	1	3	3	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr19:9048094G>T	uc002mkp.2	-	5	33741	c.33537C>A	c.(33535-33537)ACC>ACA	p.T11179T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11181	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATGAAGTTGTGGTCTCTGGTT	0.463													9	34					0.000274275	0.000322273	1	0	T	9048094	T	T	9048094	2	4	149	1	0	0	0	0	0	0	0	1	10026	1335	47	4		4	MUC16	19	9048094	Silent	SNP	G	TCGA-CR-7380-01A-11D-2012-08	3896684	9048094	50080889	103	27334											
LPPR2	64748	broad.mit.edu	37	chr19	11470367	11470367	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcctcctgctcttgtctacGcactggtcactgccgggccc	3	11	10	17	2	3	0	1	0	2	0	4	0	4	0	4	2	4	2	4	2	1	2	rs142818555		TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr19:11470367G>A	uc002mre.1	+	4	563	c.226G>A	c.(226-228)GCA>ACA	p.A76T	LPPR2_uc002mrf.1_Missense_Mutation_p.A51T|LPPR2_uc010dxy.1_5'Flank	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	76	Helical; (Potential).					integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						TCTTGTCTACGCACTGGTCAC	0.637													10	38					0	0	0	0	A	11470367	A	A	11470367	3	1	149	1	0	0	0	0	1	0	0	0	8975	1087	38	1	232	1	LPPR2	19	11470367	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	2422273	11470367	47658616	104	27335											
DCAF15	90379	broad.mit.edu	37	chr19	14069867	14069867	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcttcttaggtgacaggagTttctgccaaatcctgtatga	9	14	9	9	0	3	2	0	2	3	0	4	3	4	3	2	2	1	2	2	2	3	4			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr19:14069867T>C	uc002mxt.2	+	7	801	c.795T>C	c.(793-795)AGT>AGC	p.S265S	DCAF15_uc002mxu.2_5'Flank	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	265										central_nervous_system(1)	1						GTGACAGGAGTTTCTGCCAAA	0.622													50	68					0	0	0	0	C	14069867	C	C	14069867	2	2	149	1	0	0	0	0	0	0	0	1	4284	1722	60	5		5	DCAF15	19	14069867	Silent	SNP	T	TCGA-CR-7380-01A-11D-2012-08	2599500	14069867	45059116	105	27336											
NOTCH3	4854	broad.mit.edu	37	chr19	15284919	15284919	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcccgacgggcccggggttCggagccaggactaggccggt	5	5	17	14	5	0	0	0	0	0	0	2	3	1	2	4	7	1	1	4	7	1	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr19:15284919C>T	uc002nan.2	-	25	4772	c.4696G>A	c.(4696-4698)GAA>AAA	p.E1566K		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1566	Extracellular (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GCCCGGGGTTCGGAGCCAGGA	0.692													11	35					0	0	0	0	T	15284919	T	T	15284919	3	4	149	1	0	0	0	0	1	0	0	0	10604	893	31	1	2305	1	NOTCH3	19	15284919	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	1215052	15284919	43844064	106	27337											
GALP	85569	broad.mit.edu	37	chr19	56693617	56693617	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctagacctgtggaaggcCatcggtgagtgagcggggag	9	7	17	8	2	0	3	0	2	0	1	2	5	1	5	3	5	1	0	3	5	2	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr19:56693617C>T	uc002qmo.1	+	4	295	c.213C>T	c.(211-213)GCC>GCT	p.A71A	GALP_uc010eti.2_3'UTR	NM_033106	NP_149097	Q9UBC7	GALP_HUMAN	galanin-like peptide isoform 1 precursor	71					neuropeptide signaling pathway	extracellular region	hormone activity				0		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		TGTGGAAGGCCATCGGTGAGT	0.483													14	18					0	0	0	0	T	56693617	T	T	56693617	2	4	149	1	0	0	0	0	0	0	0	1	6261	581	21	4		4	GALP	19	56693617	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08	41408698	56693617	2435366	107	27338											
PLCB1	23236	broad.mit.edu	37	chr20	8755221	8755221	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccctgatcatggttcatcaaCgattgagcaagacctcgctg	10	10	9	12	2	3	3	3	2	0	1	4	4	3	3	2	1	2	3	2	1	2	2			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr20:8755221C>T	uc002wnb.2	+	27	2969	c.2966C>T	c.(2965-2967)ACG>ATG	p.T989M	PLCB1_uc010zrb.1_Missense_Mutation_p.T888M|PLCB1_uc002wna.2_Missense_Mutation_p.T989M|PLCB1_uc002wnc.1_Missense_Mutation_p.T888M|PLCB1_uc002wnd.1_Missense_Mutation_p.T566M	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	989					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GGTTCATCAACGATTGAGCAA	0.463													42	89					0	0	0	0	T	8755221	T	T	8755221	3	4	149	1	0	0	0	0	1	0	0	0	12082	536	19	1	3072	1	PLCB1	20	8755221	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08		8755221	54270299	108	27339											
ACSS1	84532	broad.mit.edu	37	chr20	24994664	24994664	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatggcagggaggatttccGccccttcttccgagggccgt	5	9	13	14	3	1	0	0	0	1	0	3	3	3	2	6	4	0	1	6	4	0	3			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr20:24994664G>A	uc002wub.2	-	9	2263	c.1385C>T	c.(1384-1386)GCG>GTG	p.A462V	ACSS1_uc002wuc.2_Missense_Mutation_p.A460V|ACSS1_uc010gdc.2_Missense_Mutation_p.A257V|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Missense_Mutation_p.A379V	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	462					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GAGGATTTCCGCCCCTTCTTC	0.587													8	18					0	0	0	0	A	24994664	A	A	24994664	3	1	149	1	0	0	0	0	1	0	0	0	188	1087	38	1	708	1	ACSS1	20	24994664	Missense_Mutation	SNP	G	TCGA-CR-7380-01A-11D-2012-08	16239443	24994664	38030856	109	27340											
ZNF831	128611	broad.mit.edu	37	chr20	57767141	57767141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccgacagcgcggagcagcCgcatgcgccctgcagccccc	6	3	12	20	5	0	0	0	0	0	0	1	2	1	1	5	1	6	3	5	1	0	0			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr20:57767141C>T	uc002yan.2	+	1	1067	c.1067C>T	c.(1066-1068)CCG>CTG	p.P356L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	356						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GCGGAGCAGCCGCATGCGCCC	0.577													23	16					0	0	0	0	T	57767141	T	T	57767141	3	4	149	1	0	0	0	0	1	0	0	0	18252	652	23	1	1069	1	ZNF831	20	57767141	Missense_Mutation	SNP	C	TCGA-CR-7380-01A-11D-2012-08	32772477	57767141	5258379	110	27341											
CELSR1	9620	broad.mit.edu	37	chr22	46776786	46776786	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctctccaggggtctcgggagCggagccccctcgctgtacac	5	7	13	16	3	2	0	0	0	2	0	5	2	2	2	3	4	3	2	3	4	1	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr22:46776786C>T	uc003bhw.1	-	22	7155	c.7155G>A	c.(7153-7155)CCG>CCA	p.P2385P	CELSR1_uc011arc.1_Silent_p.P706P	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2385	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GTCTCGGGAGCGGAGCCCCCT	0.627													17	38					0	0	0	0	T	46776786	T	T	46776786	2	4	149	1	0	0	0	0	0	0	0	1	3236	755	27	1		1	CELSR1	22	46776786	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08		46776786	4527780	111	27342											
PLXNB2	23654	broad.mit.edu	37	chr22	50716420	50716420	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacgctctggaagaagttgTccacaaactgctgcagtgtg	10	9	12	10	1	1	1	0	0	1	1	2	2	2	2	1	1	3	5	1	1	3	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chr22:50716420T>C	uc003bkv.3	-	32	5016	c.4910A>G	c.(4909-4911)GAC>GGC	p.D1637G	PLXNB2_uc003bkt.1_Missense_Mutation_p.D429G|PLXNB2_uc003bku.1_Missense_Mutation_p.D622G	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1637	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GAAGAAGTTGTCCACAAACTG	0.657													22	37					0	0	0	0	C	50716420	C	C	50716420	3	2	149	1	0	0	0	0	1	0	0	0	12179	1667	58	5	630	5	PLXNB2	22	50716420	Missense_Mutation	SNP	T	TCGA-CR-7380-01A-11D-2012-08	3939634	50716420	588146	112	27343											
PASD1	139135	broad.mit.edu	37	chrX	150832808	150832808	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggacctgggggctgctggCgcaagtgctcaggtactctg	5	9	17	10	1	2	0	1	0	1	0	2	1	2	1	1	5	3	5	1	5	2	1			TCGA-CR-7380-01A-11D-2012-08	TCGA-CR-7380-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ac968fdd-970b-41fc-99f7-5670c741bc06	37d0d99a-d9a4-472e-aa15-50dd1650e9d2	g.chrX:150832808C>T	uc004fev.3	+	11	1391	c.1059C>T	c.(1057-1059)GGC>GGT	p.G353G		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	353						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGGCTGCTGGCGCAAGTGCTC	0.552													12	23					0	0	0	0	T	150832808	T	T	150832808	2	4	149	1	0	0	0	0	0	0	0	1	11525	755	27	1		1	PASD1	23	150832808	Silent	SNP	C	TCGA-CR-7380-01A-11D-2012-08		150832808	4437752	113	27344											
KIAA0090	23065	broad.mit.edu	37	chr1	19577911	19577911	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttccacacgtacgcaccaAtcaaacttgcccacttggtc	10	10	6	15	2	1	0	1	0	0	0	3	0	2	0	3	1	3	3	3	1	3	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:19577911A>G	uc001bbo.2	-	1	136	c.93T>C	c.(91-93)GAT>GAC	p.D31D	KIAA0090_uc001bbp.2_Silent_p.D31D|KIAA0090_uc001bbq.2_Silent_p.D31D|KIAA0090_uc001bbr.2_Silent_p.D31D|MRTO4_uc001bbs.2_5'Flank	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	31	Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		GTACGCACCAATCAAACTTGC	0.493													9	48					0	0	0	0	G	19577911	G	G	19577911	2	3	150	1	0	0	0	0	0	0	0	1	8192	98	4	5		5	KIAA0090	1	19577911	Silent	SNP	A	TCGA-CR-7382-01A-11D-2129-08		19577911	229672710	1	27345											
ZNF362	149076	broad.mit.edu	37	chr1	33745847	33745847	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagccagagccgcctcatcGcctcgtcccccaccctcatc	6	6	6	23	3	2	1	2	0	0	1	6	1	3	1	8	0	2	0	8	0	0	0			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:33745847G>A	uc001bxc.1	+	5	642	c.472G>A	c.(472-474)GCC>ACC	p.A158T		NM_152493	NP_689706	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	158					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CCGCCTCATCGCCTCGTCCCC	0.682													8	124					0	0	0	0	A	33745847	A	A	33745847	3	1	150	1	0	0	0	0	1	0	0	0	17935	1087	38	1	486	1	ZNF362	1	33745847	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	14167936	33745847	215504774	2	27346											
DBT	1629	broad.mit.edu	37	chr1	100672165	100672165	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aatcaaaccctgctcagtatCcattgctatcccaatgttat	12	13	4	12	0	2	0	2	0	0	0	4	0	4	0	3	0	3	4	3	0	6	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:100672165C>G	uc001dta.2	-	9	1078	c.1045G>C	c.(1045-1047)GAT>CAT	p.D349H	DBT_uc010oug.1_Missense_Mutation_p.D168H	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	349					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TGCTCAGTATCCATTGCTATC	0.388													33	252					0	0	0	0	G	100672165	G	G	100672165	3	3	150	1	0	0	0	0	1	0	0	0	4275	855	30	2	415	2	DBT	1	100672165	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	66926318	100672165	148578456	3	27347											
PSMB4	5692	broad.mit.edu	37	chr1	151373293	151373293	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctatgaagccccttcgctggCcactggttatggtgcatact	7	12	10	12	1	0	1	0	1	0	0	1	1	0	1	3	3	3	3	3	3	4	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:151373293C>T	uc001eyc.1	+	4	571	c.548C>T	c.(547-549)GCC>GTC	p.A183V	PSMB4_uc010pda.1_3'UTR|PSMB4_uc001eyb.1_3'UTR	NM_002796	NP_002787	P28070	PSB4_HUMAN	proteasome beta 4 subunit	183					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCTTCGCTGGCCACTGGTTAT	0.358													35	302					0	0	0	0	T	151373293	T	T	151373293	3	4	150	1	0	0	0	0	1	0	0	0	12741	739	26	4	562	4	PSMB4	1	151373293	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	50701128	151373293	97877328	4	27348											
NID1	4811	broad.mit.edu	37	chr1	236175241	236175241	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctccgggcacgcaacggaagCcgtctccctgataaccaggt	9	6	11	15	4	1	1	0	1	1	0	3	2	2	2	4	3	3	2	4	3	3	1			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:236175241C>T	uc001hxo.2	-	12	2609	c.2507G>A	c.(2506-2508)GGC>GAC	p.G836D	NID1_uc009xgd.2_Intron|NID1_uc009xgc.2_5'UTR	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	836	EGF-like 5; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCAACGGAAGCCGTCTCCCTG	0.577													8	89					0	0	0	0	T	236175241	T	T	236175241	3	4	150	1	0	0	0	0	1	0	0	0	10468	739	26	4	1272	4	NID1	1	236175241	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	84801948	236175241	13075380	5	27349											
RYR2	6262	broad.mit.edu	37	chr1	237961367	237961367	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatggagagttctacggcCgagacagaatcagtgaatta	15	9	11	6	2	2	4	1	1	1	3	2	6	2	4	1	2	1	1	1	2	6	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:237961367C>T	uc001hyl.1	+	97	14107	c.13987C>T	c.(13987-13989)CGA>TGA	p.R4663*	RYR2_uc010pyb.1_Nonsense_Mutation_p.R96*	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4663					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTTCTACGGCCGAGACAGAAT	0.408													3	17					0	0	0	0	T	237961367	T	T	237961367	4	4	150	1	0	0	0	0	0	1	0	0	13834	644	23	1	14373	1	RYR2	1	237961367	Nonsense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	1786126	237961367	11289254	6	27350											
C1orf101	257044	broad.mit.edu	37	chr1	244735832	244735832	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacaggactatcccttacatCtggaagcacaaagtatagct	14	10	7	10	0	1	0	0	0	1	0	2	2	2	2	1	2	4	3	1	2	7	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr1:244735832C>G	uc001iam.2	+	11	1767	c.1708C>G	c.(1708-1710)CTG>GTG	p.L570V	C1orf101_uc001iak.1_Missense_Mutation_p.L124V|C1orf101_uc001ial.2_Missense_Mutation_p.L570V|C1orf101_uc010pym.1_Missense_Mutation_p.L419V|C1orf101_uc010pyn.1_Missense_Mutation_p.L503V	NM_001130957	NP_001124429	Q5SY80	CA101_HUMAN	hypothetical protein LOC257044 isoform 1	570	Extracellular (Potential).					integral to membrane				ovary(1)|breast(1)	2	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			TCCCTTACATCTGGAAGCACA	0.363													8	70					0	0	0	0	G	244735832	G	G	244735832	3	3	150	1	0	0	0	0	1	0	0	0	1985	912	32	2	1750	2	C1orf101	1	244735832	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	6774465	244735832	4514789	7	27351											
PLEKHH2	130271	broad.mit.edu	37	chr2	43984289	43984289	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agattttgaaagacctttctCaactccagcagggcatgtta	12	12	8	9	0	1	3	1	1	1	2	3	3	2	3	2	1	2	3	2	1	3	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:43984289C>T	uc010yny.1	+	26	3910	c.3827C>T	c.(3826-3828)TCA>TTA	p.S1276L		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1276	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGACCTTTCTCAACTCCAGCA	0.333													6	84					0	0	0	0	T	43984289	T	T	43984289	3	4	150	1	0	0	0	0	1	0	0	0	12132	838	29	2	3925	2	PLEKHH2	2	43984289	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08		43984289	199215084	8	27352											
TMEM37	140738	broad.mit.edu	37	chr2	120194495	120194495	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgggccaaaggcagcccCgccggtccttctttgaatcc	6	10	10	15	2	1	1	0	1	1	0	3	1	3	1	6	3	1	1	6	3	2	3	rs141678483		TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:120194495C>T	uc002tly.2	+	2	86	c.52C>T	c.(52-54)CGC>TGC	p.R18C		NM_183240	NP_899063	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	18						integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)	1						AAGGCAGCCCCGCCGGTCCTT	0.612													12	73					0	0	0	0	T	120194495	T	T	120194495	3	4	150	1	0	0	0	0	1	0	0	0	16224	652	23	1	58	1	TMEM37	2	120194495	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	76210206	120194495	123004878	9	27353											
MYO7B	4648	broad.mit.edu	37	chr2	128389183	128389183	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacagccacacccatcctcCggtacatgggcgactaccct	9	7	8	17	2	0	1	0	1	0	0	2	2	2	1	5	2	3	1	5	2	2	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:128389183C>T	uc002top.2	+	37	5079	c.5026C>T	c.(5026-5028)CGG>TGG	p.R1676W	MYO7B_uc002tos.1_5'Flank|MYO7B_uc002tot.2_5'Flank	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1676	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ACCCATCCTCCGGTACATGGG	0.677													7	34					0	0	0	0	T	128389183	T	T	128389183	3	4	150	1	0	0	0	0	1	0	0	0	10136	643	23	1	5168	1	MYO7B	2	128389183	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	8194688	128389183	114810190	10	27354											
PKP4	8502	broad.mit.edu	37	chr2	159535144	159535144	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcctattcctcaccagcaaGagaacaaaatagacggctac	15	8	6	12	1	1	2	1	0	0	2	3	3	3	2	3	1	3	2	3	1	7	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:159535144G>C	uc002tzv.2	+	21	3568	c.3308G>C	c.(3307-3309)AGA>ACA	p.R1103T	PKP4_uc002tzw.2_Missense_Mutation_p.R1060T|PKP4_uc002tzx.2_Missense_Mutation_p.R760T|PKP4_uc002uaa.2_Missense_Mutation_p.R912T|uc002uab.1_Intron|PKP4_uc002uac.2_Missense_Mutation_p.R284T|PKP4_uc002uad.2_RNA	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	1103					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						TCACCAGCAAGAGAACAAAAT	0.383										HNSCC(62;0.18)			18	71					0	0	0	0	C	159535144	C	C	159535144	3	2	150	1	0	0	0	0	1	0	0	0	12042	942	33	2	3386	2	PKP4	2	159535144	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	31145961	159535144	83664229	11	27355											
CASP8	841	broad.mit.edu	37	chr2	202149644	202149644	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatctaccaactcatggAccacagtaacatggactgct	15	8	7	11	0	2	0	1	0	1	0	2	3	2	2	2	2	4	2	2	2	5	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:202149644A>G	uc002uxr.1	+	9	1117	c.908A>G	c.(907-909)GAC>GGC	p.D303G	CASP8_uc002uxp.1_Missense_Mutation_p.D320G|CASP8_uc002uxq.1_Missense_Mutation_p.D288G|CASP8_uc002uxt.1_Missense_Mutation_p.D362G|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Missense_Mutation_p.D288G|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Missense_Mutation_p.D219G	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	303					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CAACTCATGGACCACAGTAAC	0.473										HNSCC(4;0.00038)			30	136					0	0	0	0	G	202149644	G	G	202149644	3	3	150	1	0	0	0	0	1	0	0	0	2689	275	10	5	1215	5	CASP8	2	202149644	Missense_Mutation	SNP	A	TCGA-CR-7382-01A-11D-2129-08	42614500	202149644	41049729	12	27356											
AGAP1	116987	broad.mit.edu	37	chr2	237032621	237032621	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagctctggcctacgcccGgcaggcctccagccaggagt	7	5	12	17	2	1	0	0	0	1	0	2	1	2	1	5	4	3	2	5	4	1	1	rs150891900		TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr2:237032621G>A	uc002vvs.2	+	18	3024	c.2429G>A	c.(2428-2430)CGG>CAG	p.R810Q	AGAP1_uc002vvt.2_Missense_Mutation_p.R757Q	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	810	ANK 2.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						GCCTACGCCCGGCAGGCCTCC	0.637													6	71					0	0	0	0	A	237032621	A	A	237032621	3	1	150	1	0	0	0	0	1	0	0	0	366	1116	39	1	2499	1	AGAP1	2	237032621	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	34882977	237032621	6166752	13	27357											
TRIM71	131405	broad.mit.edu	37	chr3	32933083	32933083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcaatgggcagttcctgcGcccacaaggggtagctgtgg	8	7	16	10	1	0	0	0	0	0	0	1	0	1	0	2	5	2	5	2	5	3	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr3:32933083G>A	uc003cff.2	+	4	2450	c.2387G>A	c.(2386-2388)CGC>CAC	p.R796H		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	796	NHL 5.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						CAGTTCCTGCGCCCACAAGGG	0.592													9	74					0	0	0	0	A	32933083	A	A	32933083	3	1	150	1	0	0	0	0	1	0	0	0	16611	1087	38	1	2401	1	TRIM71	3	32933083	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08		32933083	165089347	14	27358											
FAM107A	11170	broad.mit.edu	37	chr3	58555543	58555543	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtattctggccgggccatCaggcccccaatgtctgcccg	5	9	11	16	2	3	0	1	0	2	0	3	0	3	0	5	3	1	1	5	3	2	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr3:58555543C>G	uc003dkm.2	-	3	604	c.45G>C	c.(43-45)CTG>CTC	p.L15L	FAM107A_uc003dko.2_Silent_p.L46L|FAM107A_uc003dkn.2_Silent_p.L15L|FAM107A_uc010hnm.2_Silent_p.L43L|FAM107A_uc003dkp.1_Silent_p.L15L	NM_007177	NP_009108	O95990	F107A_HUMAN	downregulated in renal cell carcinoma	15			L -> M (in ovarian cancer and renal cell carcinoma cell lines).		regulation of cell growth	nucleus	protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000189)|Kidney(10;0.000536)|KIRC - Kidney renal clear cell carcinoma(10;0.000716)|OV - Ovarian serous cystadenocarcinoma(275;0.154)		GCCGGGCCATCAGGCCCCCAA	0.597													12	95					0	0	0	0	G	58555543	G	G	58555543	2	3	150	1	0	0	0	0	0	0	0	1	5417	813	29	2		2	FAM107A	3	58555543	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08	25622460	58555543	139466887	15	27359											
PVRL3	25945	broad.mit.edu	37	chr3	110852576	110852576	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagaacctaaaaaattgccCttcccattgtcaactttggc	13	11	5	12	0	1	1	1	0	0	1	2	1	2	1	3	1	3	0	3	1	5	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr3:110852576C>T	uc003dxt.1	+	6	1164	c.1164C>T	c.(1162-1164)CCC>CCT	p.P388P	PVRL3_uc003dxu.1_Intron	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	388	Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						AAAAATTGCCCTTCCCATTGT	0.443													5	111					0	0	0	0	T	110852576	T	T	110852576	2	4	150	1	0	0	0	0	0	0	0	1	12906	668	24	4		4	PVRL3	3	110852576	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08	52297033	110852576	87169854	16	27360											
MFN1	55669	broad.mit.edu	37	chr3	179076745	179076745	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaggaactgatggagataaAgcctatcttatgacagaagg	16	8	12	5	0	1	4	0	2	1	2	1	7	1	5	1	3	2	0	1	3	7	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr3:179076745A>C	uc003fjs.2	+	4	492	c.366A>C	c.(364-366)AAA>AAC	p.K122N	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.K150N	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	122	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			ATGGAGATAAAGCCTATCTTA	0.373													10	79					0	0	0	0	C	179076745	C	C	179076745	3	2	150	1	0	0	0	0	1	0	0	0	9576	69	3	5	376	5	MFN1	3	179076745	Missense_Mutation	SNP	A	TCGA-CR-7382-01A-11D-2129-08	68224169	179076745	18945685	17	27361											
HGFAC	3083	broad.mit.edu	37	chr4	3445789	3445789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctggatccctgtgcctccGgcccctgcctcaatggaggc	4	8	11	18	1	1	0	1	0	0	0	3	2	3	2	7	4	2	0	7	4	1	0			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:3445789G>A	uc003ghc.2	+	5	502	c.499G>A	c.(499-501)GGC>AGC	p.G167S	HGFAC_uc010icw.2_Missense_Mutation_p.G167S	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	167	EGF-like 1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CTGTGCCTCCGGCCCCTGCCT	0.662													9	59					0	0	0	0	A	3445789	A	A	3445789	3	1	150	1	0	0	0	0	1	0	0	0	7125	1116	39	1	517	1	HGFAC	4	3445789	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08		3445789	187708487	18	27362											
SORCS2	57537	broad.mit.edu	37	chr4	7726911	7726911	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggccctctacctggaggtggTtcctgtcattggcctcaacc	5	11	11	14	0	3	0	2	0	1	0	4	1	4	1	5	5	2	1	5	5	2	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:7726911T>C	uc003gkb.3	+	20	2642	c.2642T>C	c.(2641-2643)GTT>GCT	p.V881A	SORCS2_uc011bwi.1_Missense_Mutation_p.V709A	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	881	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						CTGGAGGTGGTTCCTGTCATT	0.577													18	61					0	0	0	0	C	7726911	C	C	7726911	3	2	150	1	0	0	0	0	1	0	0	0	14995	1725	60	5	2720	5	SORCS2	4	7726911	Missense_Mutation	SNP	T	TCGA-CR-7382-01A-11D-2129-08	4281122	7726911	183427365	19	27363											
SCLT1	132320	broad.mit.edu	37	chr4	129864211	129864211	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttaaactctcagtctctttCcgtaactgtttattttcttg	7	20	4	10	1	3	0	1	0	3	0	6	0	4	0	1	0	2	2	1	0	4	8			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:129864211C>T	uc003igp.2	-	17	2078	c.1572G>A	c.(1570-1572)CGG>CGA	p.R524R	SCLT1_uc003ign.2_Silent_p.R188R|SCLT1_uc003igo.2_Silent_p.R134R|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	524	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						CAGTCTCTTTCCGTAACTGTT	0.363													8	92					0	0	0	0	T	129864211	T	T	129864211	2	4	150	1	0	0	0	0	0	0	0	1	13971	842	30	2		2	SCLT1	4	129864211	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08	122137300	129864211	61290065	20	27364											
SCLT1	132320	broad.mit.edu	37	chr4	129873944	129873944	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttgaagggctgaaagttCttctgttaatcgagaaattt	12	15	9	5	1	2	3	0	2	2	1	3	4	2	3	0	1	0	3	0	1	4	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:129873944C>A	uc003igp.2	-	14	1704	c.1198G>T	c.(1198-1200)GAA>TAA	p.E400*	SCLT1_uc003ign.2_Nonsense_Mutation_p.E64*|SCLT1_uc003igo.2_5'UTR|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	400	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						GCTGAAAGTTCTTCTGTTAAT	0.269													8	90					0.000157383	0.000165524	1	0	A	129873944	A	A	129873944	4	1	150	1	0	0	0	0	0	1	0	0	13971	922	32	2	900	2	SCLT1	4	129873944	Nonsense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	9733	129873944	61280332	21	27365											
ZNF827	152485	broad.mit.edu	37	chr4	146767142	146767142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatggtgttttcttttgtatGattgtgctctttgctcactt	4	22	9	6	0	3	1	1	1	2	0	3	2	3	1	0	1	2	4	0	1	1	8			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:146767142G>A	uc003ikn.2	-	7	2293	c.2245C>T	c.(2245-2247)CAT>TAT	p.H749Y	ZNF827_uc003ikm.2_Missense_Mutation_p.H749Y|ZNF827_uc010iox.2_Missense_Mutation_p.H399Y	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	749					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					TCTTTTGTATGATTGTGCTCT	0.463													4	48					0	0	0	0	A	146767142	A	A	146767142	3	1	150	1	0	0	0	0	1	0	0	0	18247	1290	45	2	1016	2	ZNF827	4	146767142	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	16893198	146767142	44387134	22	27366											
FAT1	2195	broad.mit.edu	37	chr4	187541184	187541184	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcaatctctgcactgtagaAaggtttttcaaacacaggca	13	11	8	9	0	2	1	1	0	1	1	3	1	2	1	0	2	3	5	0	2	4	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr4:187541184A>C	uc003izf.2	-	10	6744	c.6556T>G	c.(6556-6558)TTC>GTC	p.F2186V		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2186	Extracellular (Potential).|Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCACTGTAGAAAGGTTTTTCA	0.507										HNSCC(5;0.00058)			6	75					0	0	0	0	C	187541184	C	C	187541184	3	2	150	1	0	0	0	0	1	0	0	0	5721	14	1	5	7282	5	FAT1	4	187541184	Missense_Mutation	SNP	A	TCGA-CR-7382-01A-11D-2129-08	40774042	187541184	3613092	23	27367											
ADAMTS12	81792	broad.mit.edu	37	chr5	33624346	33624346	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttattaccagatccttcCttctgcttaaacatctttct	8	19	3	11	0	3	1	0	0	3	1	5	1	5	1	3	0	3	2	3	0	4	7			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:33624346C>T	uc003jia.1	-	14	2296	c.2133G>A	c.(2131-2133)AAG>AAA	p.K711K	ADAMTS12_uc010iuq.1_Intron	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	711	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CAGATCCTTCCTTCTGCTTAA	0.453										HNSCC(64;0.19)			6	104					0	0	0	0	T	33624346	T	T	33624346	2	4	150	1	0	0	0	0	0	0	0	1	257	680	24	4		4	ADAMTS12	5	33624346	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08		33624346	147290914	24	27368											
HEATR7B2	133558	broad.mit.edu	37	chr5	41008749	41008749	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgttctccctgctgcatCacatgccgcctatggctcca	5	12	8	16	1	2	0	1	0	1	0	4	0	3	0	4	1	4	5	4	1	1	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:41008749C>T	uc003jmj.3	-	33	4057	c.3567G>A	c.(3565-3567)GTG>GTA	p.V1189V	HEATR7B2_uc003jmi.3_Silent_p.V744V	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1189	HEAT 13.						binding			ovary(6)|central_nervous_system(2)	8						CCTGCTGCATCACATGCCGCC	0.567													5	39					0	0	0	0	T	41008749	T	T	41008749	2	4	150	1	0	0	0	0	0	0	0	1	7074	813	29	2		2	HEATR7B2	5	41008749	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08	7384403	41008749	139906511	25	27369											
DDX4	54514	broad.mit.edu	37	chr5	55082475	55082475	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacgagatttgatggcttgcGctcaaacagggtctgggaag	10	9	15	7	2	2	2	1	1	1	1	2	5	2	3	0	3	2	2	0	3	2	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:55082475G>A	uc003jqg.3	+	14	1068	c.994G>A	c.(994-996)GCT>ACT	p.A332T	DDX4_uc010ivz.2_Missense_Mutation_p.A312T|DDX4_uc003jqh.3_Missense_Mutation_p.A298T|DDX4_uc003jqj.2_Missense_Mutation_p.A183T	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	332	ATP (By similarity).|Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				GATGGCTTGCGCTCAAACAGG	0.398													8	136					0	0	0	0	A	55082475	A	A	55082475	3	1	150	1	0	0	0	0	1	0	0	0	4377	1087	38	1	1085	1	DDX4	5	55082475	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	14073726	55082475	125832785	26	27370											
CMYA5	202333	broad.mit.edu	37	chr5	79030604	79030604	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtagagagaaacatagcaGaggggaaggagattcattct	16	8	13	4	0	2	4	1	0	1	4	2	7	2	5	0	3	2	2	0	3	4	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:79030604G>C	uc003kgc.2	+	2	6088	c.6016G>C	c.(6016-6018)GAG>CAG	p.E2006Q		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2006						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAACATAGCAGAGGGGAAGGA	0.408													5	45					0	0	0	0	C	79030604	C	C	79030604	3	2	150	1	0	0	0	0	1	0	0	0	3605	943	33	2	6022	2	CMYA5	5	79030604	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	23948129	79030604	101884656	27	27371											
PCDHGB7	56099	broad.mit.edu	37	chr5	140799485	140799485	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccctctgactcccaggctGagatgcagttttacctggtg	7	11	10	13	0	1	2	0	2	1	1	2	3	2	2	3	2	2	3	3	2	1	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:140799485G>A	uc003lkn.1	+	1	2204	c.2059G>A	c.(2059-2061)GAG>AAG	p.E687K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.E687K|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	687	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCCAGGCTGAGATGCAGTT	0.552													8	72					0	0	0	0	A	140799485	A	A	140799485	3	1	150	1	0	0	0	0	1	0	0	0	11622	1291	45	2	2061	2	PCDHGB7	5	140799485	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	61768881	140799485	40115775	28	27372											
ODZ2	57451	broad.mit.edu	37	chr5	167689098	167689098	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagagagacataaccaggcCttcatggctctggaaggaca	14	6	11	10	0	2	2	1	0	1	2	2	5	2	4	2	4	1	1	2	4	2	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:167689098C>G	uc010jjd.2	+	29	7581	c.7581C>G	c.(7579-7581)GCC>GCG	p.A2527A	ODZ2_uc003lzr.3_Silent_p.A2297A|ODZ2_uc003lzt.3_Silent_p.A1900A|ODZ2_uc010jje.2_Silent_p.A1791A	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ATAACCAGGCCTTCATGGCTC	0.507													6	42					0	0	0	0	G	167689098	G	G	167689098	2	3	150	1	0	0	0	0	0	0	0	1	10889	668	24	4		4	ODZ2	5	167689098	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08	26889613	167689098	13226162	29	27373											
DOCK2	1794	broad.mit.edu	37	chr5	169477279	169477279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacaaagtgttcatctaccGcgggaaggaatatgagcgaa	15	7	12	7	3	2	1	1	1	1	0	2	5	2	3	1	2	3	1	1	2	7	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:169477279G>A	uc003maf.2	+	41	4171	c.4091G>A	c.(4090-4092)CGC>CAC	p.R1364H	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.R856H	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1364	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCATCTACCGCGGGAAGGAA	0.502													19	175					0	0	0	0	A	169477279	A	A	169477279	3	1	150	1	0	0	0	0	1	0	0	0	4709	1087	38	1	4253	1	DOCK2	5	169477279	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	1788181	169477279	11437981	30	27374											
HK3	3101	broad.mit.edu	37	chr5	176314244	176314244	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagtctcgggaatggagtaGatctcgctggtgatctgcac	9	10	13	9	2	3	2	0	1	3	1	5	4	3	4	0	3	1	3	0	3	2	1			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr5:176314244G>C	uc003mfa.2	-	12	1787	c.1695C>G	c.(1693-1695)ATC>ATG	p.I565M	HK3_uc003mez.2_Missense_Mutation_p.I121M	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	565	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAATGGAGTAGATCTCGCTGG	0.622													11	55					0	0	0	0	C	176314244	C	C	176314244	3	2	150	1	0	0	0	0	1	0	0	0	7231	932	33	2	1108	2	HK3	5	176314244	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	6836965	176314244	4601016	31	27375											
GPR116	221395	broad.mit.edu	37	chr6	46847692	46847692	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catagcgccaagacacattgGaggacaaaacttccttttca	14	9	7	11	1	1	1	1	0	0	1	2	3	2	3	2	2	2	0	2	2	4	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr6:46847692G>A	uc003oyo.3	-	9	1188	c.899C>T	c.(898-900)TCC>TTC	p.S300F	GPR116_uc003oyp.3_Intron|GPR116_uc003oyq.3_Missense_Mutation_p.S300F|GPR116_uc010jzi.1_5'UTR|GPR116_uc003oyr.2_Missense_Mutation_p.S300F	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	300	Ig-like 1.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			AGACACATTGGAGGACAAAAC	0.438													9	80					0	0	0	0	A	46847692	A	A	46847692	3	1	150	1	0	0	0	0	1	0	0	0	6671	1174	41	2	3193	2	GPR116	6	46847692	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08		46847692	124267375	32	27376											
CCDC28A	25901	broad.mit.edu	37	chr6	139101031	139101031	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaactccgatccagcactcCttcctcactgatgtctcaga	9	11	5	16	1	3	2	3	1	1	1	8	3	7	2	4	0	2	1	4	0	1	1			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr6:139101031C>T	uc003qie.2	+	3	656	c.501C>T	c.(499-501)TCC>TCT	p.S167S		NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	167											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TCCAGCACTCCTTCCTCACTG	0.453													10	82					0	0	0	0	T	139101031	T	T	139101031	2	4	150	1	0	0	0	0	0	0	0	1	2815	668	24	4		4	CCDC28A	6	139101031	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08	92253339	139101031	32014036	33	27377											
SEMA3E	9723	broad.mit.edu	37	chr7	83014672	83014672	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactttcgcttgtaaagatcGtggggtacattccagcaaag	12	11	10	8	2	0	1	0	0	0	1	3	1	1	1	1	2	3	4	1	2	5	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr7:83014672G>A	uc003uhy.1	-	16	2279	c.1813C>T	c.(1813-1815)CGA>TGA	p.R605*		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	605	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TGTAAAGATCGTGGGGTACAT	0.398													20	132					0	0	0	0	A	83014672	A	A	83014672	4	1	150	1	0	0	0	0	0	1	0	0	14093	1153	40	1	522	1	SEMA3E	7	83014672	Nonsense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08		83014672	76123991	34	27378											
COL1A2	1278	broad.mit.edu	37	chr7	94051241	94051241	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttccctggtgctgctggaCggactggtcccccaggaccc	4	9	13	15	1	0	0	0	0	0	0	2	3	2	3	4	5	2	3	4	5	0	1			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr7:94051241C>T	uc003ung.1	+	39	2851	c.2380C>T	c.(2380-2382)CGG>TGG	p.R794W	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	794			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGCTGCTGGACGGACTGGTCC	0.458										HNSCC(75;0.22)			6	57					0	0	0	0	T	94051241	T	T	94051241	3	4	150	1	0	0	0	0	1	0	0	0	3693	527	19	1	2534	1	COL1A2	7	94051241	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	11036569	94051241	65087422	35	27379											
ZKSCAN5	23660	broad.mit.edu	37	chr7	99117510	99117510	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccaggagctgacagcttCacttctctcaactgggtccc	8	9	9	15	0	3	1	2	1	1	0	5	2	4	2	2	2	4	2	2	2	1	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr7:99117510C>A	uc003uqv.2	+	4	738	c.614C>A	c.(613-615)TCA>TAA	p.S205*	ZKSCAN5_uc010lfx.2_Nonsense_Mutation_p.S205*|ZKSCAN5_uc003uqw.2_Nonsense_Mutation_p.S205*|ZKSCAN5_uc003uqx.2_Intron|ZKSCAN5_uc003uqy.2_5'UTR	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	205					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CTGACAGCTTCACTTCTCTCA	0.517													11	69					2.27111e-07	2.43049e-07	1	0	A	99117510	A	A	99117510	4	1	150	1	0	0	0	0	0	1	0	0	17757	838	29	2	624	2	ZKSCAN5	7	99117510	Nonsense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	5066269	99117510	60021153	36	27380											
IQUB	154865	broad.mit.edu	37	chr7	123142651	123142651	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaataaaagttatctcacCgcctttagtctttgagcatg	12	13	6	10	1	2	1	1	1	2	0	3	1	2	1	2	0	1	2	2	0	5	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr7:123142651C>T	uc003vkn.2	-	6	1600	c.1023G>A	c.(1021-1023)GCG>GCA	p.A341A	IQUB_uc003vko.2_Silent_p.A341A|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Silent_p.A341A|IQUB_uc003vkq.2_3'UTR	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	341	IQ.									ovary(3)|large_intestine(1)	4						GTTATCTCACCGCCTTTAGTC	0.358													6	71					0	0	0	0	T	123142651	T	T	123142651	2	4	150	1	0	0	0	0	0	0	0	1	7859	666	23	1		1	IQUB	7	123142651	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08	24025141	123142651	35996012	37	27381											
PTPRN2	5799	broad.mit.edu	37	chr7	158380276	158380277	+	Frame_Shift_Ins	INS	-	G	G																															ccccgggagctgccggccgcINSgggggacggacgaaggggcg																										TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr7:158380276_158380277insG	uc003wno.2	-	1	206_207	c.85_86insC	c.(85-87)CGCfs	p.R29fs	PTPRN2_uc003wnp.2_Frame_Shift_Ins_p.R29fs|PTPRN2_uc003wnq.2_Frame_Shift_Ins_p.R29fs|PTPRN2_uc003wnr.2_Frame_Shift_Ins_p.R29fs	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	29	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CTGCCGGCCGCGGGGGACGGAC	0.594													---	---	---								G	158380277	G	G	158380276	7	5	150	1	0	1	1	0	0	0	0	0	12873	768	27	0	3053	0	PTPRN2	7	158380276	Frame_Shift_Ins	INS	-	TCGA-CR-7382-01A-11D-2129-08	35237625	158380276	758387	38	27382											
XPO7	23039	broad.mit.edu	37	chr8	21843104	21843104	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcctgctgcaggaaggctGacatggctggtttacattat	8	13	11	9	0	1	1	0	1	1	0	2	2	1	2	1	4	3	5	1	4	3	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr8:21843104G>A	uc003xaa.3	+	13	1581	c.1479G>A	c.(1477-1479)CTG>CTA	p.L493L	XPO7_uc010lti.2_Silent_p.L502L|XPO7_uc010ltk.2_Silent_p.L494L	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	493					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		CAGGAAGGCTGACATGGCTGG	0.498													40	139					0	0	0	0	A	21843104	A	A	21843104	2	1	150	1	0	0	0	0	0	0	0	1	17517	1277	45	2		2	XPO7	8	21843104	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08		21843104	124520918	39	27383											
UBR5	51366	broad.mit.edu	37	chr8	103305835	103305835	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacctggtagcaatttacctGctagactgatcagatgatgg	11	12	10	8	0	1	4	1	2	0	2	1	4	1	4	2	2	4	3	2	2	5	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr8:103305835G>A	uc003ykr.1	-	34	4620	c.4587C>T	c.(4585-4587)AGC>AGT	p.S1529S	UBR5_uc003yks.1_Silent_p.S1529S	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1529	Poly-Ser.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CAATTTACCTGCTAGACTGAT	0.433													11	99					0	0	0	0	A	103305835	A	A	103305835	2	1	150	1	0	0	0	0	0	0	0	1	16973	1310	46	4		4	UBR5	8	103305835	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08	81462731	103305835	43058187	40	27384											
TRAPPC9	83696	broad.mit.edu	37	chr8	140744267	140744267	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacgaaggagacggtgtcGtgcaggtcgtagttgtgcac	8	8	15	10	4	0	1	0	0	0	1	2	3	0	1	1	3	2	4	1	3	2	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr8:140744267G>A	uc003yvj.2	-	22	3368	c.3234C>T	c.(3232-3234)CAC>CAT	p.H1078H	TRAPPC9_uc003yvh.2_Silent_p.H1176H	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	1078					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						AGACGGTGTCGTGCAGGTCGT	0.657													5	11					0	0	0	0	A	140744267	A	A	140744267	2	1	150	1	0	0	0	0	0	0	0	1	16532	1136	40	1		1	TRAPPC9	8	140744267	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08	37438432	140744267	5619755	41	27385											
EPPK1	83481	broad.mit.edu	37	chr8	144940690	144940690	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccacatggcctggtagatGctcatcttctcctggcggcc	5	12	10	14	1	3	1	1	0	2	1	5	1	4	1	4	4	1	2	4	4	1	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr8:144940690G>A	uc003zaa.1	-	2	14755	c.14742C>T	c.(14740-14742)AGC>AGT	p.S4914S		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4914	Plectin 61.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTGGTAGATGCTCATCTTCT	0.711													7	102					0	0	0	0	A	144940690	A	A	144940690	2	1	150	1	0	0	0	0	0	0	0	1	5214	1310	46	4		4	EPPK1	8	144940690	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08	4196423	144940690	1423332	42	27386											
KIAA1797	54914	broad.mit.edu	37	chr9	20789459	20789459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcaagtgactggttggCttcagtagagtcattgcttc	7	14	12	8	0	2	2	2	1	0	1	3	2	2	2	0	2	3	6	0	2	2	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:20789459C>T	uc003zog.1	+	13	1670	c.1307C>T	c.(1306-1308)GCT>GTT	p.A436V		NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	436						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		GACTGGTTGGCTTCAGTAGAG	0.463													11	84					0	0	0	0	T	20789459	T	T	20789459	3	4	150	1	0	0	0	0	1	0	0	0	8297	797	28	4	1345	4	KIAA1797	9	20789459	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08		20789459	120423972	43	27387											
CD72	971	broad.mit.edu	37	chr9	35618375	35618375	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcccctctcgtctctgtccGtttacaactaggctctgtgt	4	15	8	14	2	3	0	0	0	3	0	6	0	4	0	3	1	3	2	3	1	3	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:35618375G>A	uc003zxb.2	-	1	50	c.-74C>T	c.(-76--72)AACGG>AATGG		CD72_uc003zxc.1_Translation_Start_Site|CD72_uc010mkt.1_Translation_Start_Site|CD72_uc010mku.2_Translation_Start_Site|CD72_uc010mkv.2_Translation_Start_Site|CD72_uc010mkw.1_Intron	NM_001782	NP_001773	P21854	CD72_HUMAN	CD72 molecule						axon guidance|cell adhesion	integral to plasma membrane	receptor binding|sugar binding|transmembrane receptor activity				0			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GTCTCTGTCCGTTTACAACTA	0.547													5	21					0	0	0	0	A	35618375	A	A	35618375	1	1	150	1	0	0	0	0	0	0	0	0	3049	1160	40	1		1	CD72	9	35618375	Translation_Start_Site	SNP	G	TCGA-CR-7382-01A-11D-2129-08	14828916	35618375	105595056	44	27388											
IGFBPL1	347252	broad.mit.edu	37	chr9	38414183	38414183	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gttgtgaacacttcggggagGaacgacgaccacaggagcta	12	6	14	9	3	0	1	0	1	0	0	1	6	0	4	1	4	3	2	1	4	3	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:38414183G>A	uc004aba.2	-	2	501	c.478C>T	c.(478-480)CCT>TCT	p.P160S		NM_001007563	NP_001007564	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like	160	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding				0				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		CTTCGGGGAGGAACGACGACC	0.592													6	83					0	0	0	0	A	38414183	A	A	38414183	3	1	150	1	0	0	0	0	1	0	0	0	7624	1174	41	2	370	2	IGFBPL1	9	38414183	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	2795808	38414183	102799248	45	27389											
PRUNE2	158471	broad.mit.edu	37	chr9	79465512	79465512	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctaaaataaacctcgtctCggtgaagtagttgaattcag	13	13	8	7	2	3	2	1	2	2	0	5	2	3	2	1	1	1	2	1	1	7	6			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:79465512C>T	uc010mpk.2	-	3	335	c.211G>A	c.(211-213)GAG>AAG	p.E71K	PRUNE2_uc004akn.2_Missense_Mutation_p.E71K	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	71					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AACCTCGTCTCGGTGAAGTAG	0.393													16	151					0	0	0	0	T	79465512	T	T	79465512	3	4	150	1	0	0	0	0	1	0	0	0	12703	893	31	1	9123	1	PRUNE2	9	79465512	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	41051329	79465512	61747919	46	27390											
DAPK1	1612	broad.mit.edu	37	chr9	90321943	90321943	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagtcgcctgctggacccGcccgaccccctggggaagga	6	5	14	16	3	0	1	0	1	0	0	1	5	0	4	5	4	1	1	5	4	1	0			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:90321943G>A	uc004apc.2	+	26	4095	c.3957G>A	c.(3955-3957)CCG>CCA	p.P1319P	DAPK1_uc004apd.2_Silent_p.P1319P|DAPK1_uc011ltg.1_Silent_p.P1253P|DAPK1_uc011lth.1_Silent_p.P1056P|DAPK1_uc004apg.2_Silent_p.P296P	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	1319	Death.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						TGCTGGACCCGCCCGACCCCC	0.602									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				9	106					0	0	0	0	A	90321943	A	A	90321943	2	1	150	1	0	0	0	0	0	0	0	1	4252	1074	38	1		1	DAPK1	9	90321943	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08	10856431	90321943	50891488	47	27391											
CENPP	401541	broad.mit.edu	37	chr9	95094556	95094556	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcagaactttcatttctaaGtacgcttactggcatcaata	13	14	5	9	1	4	1	3	0	1	1	4	1	4	1	0	1	3	3	0	1	6	6			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:95094556G>C	uc004arz.2	+	2	752	c.212G>C	c.(211-213)AGT>ACT	p.S71T	CENPP_uc010mqx.2_Intron|CENPP_uc004ary.1_Missense_Mutation_p.S71T	NM_001012267	NP_001012267	Q6IPU0	CENPP_HUMAN	centromere protein P	71	Potential.				CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				ovary(2)	2						TCATTTCTAAGTACGCTTACT	0.348													4	31					0	0	0	0	C	95094556	C	C	95094556	3	2	150	1	0	0	0	0	1	0	0	0	3255	1029	36	4	218	4	CENPP	9	95094556	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	4772613	95094556	46118875	48	27392											
TMOD1	7111	broad.mit.edu	37	chr9	100331211	100331211	+	Silent	SNP	G	A	A																															ctcaaggagaacaaggtgttGaagacactgaatgtggaatc																										TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:100331211G>A	uc004axk.1	+	8	975	c.762G>A	c.(760-762)TTG>TTA	p.L254L	TMOD1_uc004axl.1_Silent_p.L254L	NM_003275	NP_003266	P28289	TMOD1_HUMAN	tropomodulin 1	254					muscle filament sliding	cytosol	actin binding				0		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		ACAAGGTGTTGAAGACACTGA	0.507													13	107					0	0	0	0	A	100331211	A	A	100331211	2	1	150	1	0	0	0	0	0	0	0	1	16299	1281	45	2		2	TMOD1	9	100331211	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08	5236655	100331211	40882220	49	27393	54	2									
TMOD1	7111	broad.mit.edu	37	chr9	100331220	100331220	+	Silent	SNP	G	A	A																															aacaaggtgttgaagacactGaatgtggaatccaacttcat																										TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:100331220G>A	uc004axk.1	+	8	984	c.771G>A	c.(769-771)CTG>CTA	p.L257L	TMOD1_uc004axl.1_Silent_p.L257L	NM_003275	NP_003266	P28289	TMOD1_HUMAN	tropomodulin 1	257					muscle filament sliding	cytosol	actin binding				0		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		TGAAGACACTGAATGTGGAAT	0.498													15	102					0	0	0	0	A	100331220	A	A	100331220	2	1	150	1	0	0	0	0	0	0	0	1	16299	1277	45	2		2	TMOD1	9	100331220	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08	9	100331220	40882211	50	27394	54	2									
GALNT12	79695	broad.mit.edu	37	chr9	101585618	101585618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttataatgaagcctggtcaaCtctccttcggacagtttaca	11	13	7	10	1	2	1	1	1	1	0	4	2	2	2	2	2	3	1	2	2	5	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:101585618C>T	uc004ayz.2	+	2	452	c.452C>T	c.(451-453)ACT>ATT	p.T151I		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	151	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				GCCTGGTCAACTCTCCTTCGG	0.428													5	84					0	0	0	0	T	101585618	T	T	101585618	3	4	150	1	0	0	0	0	1	0	0	0	6245	565	20	4	458	4	GALNT12	9	101585618	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	1254398	101585618	39627813	51	27395											
FNBP1	23048	broad.mit.edu	37	chr9	132740854	132740854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctgcgtaatcattcatttCgttcaggttggaaatgaaag	11	13	9	8	2	3	1	3	1	0	0	4	2	3	2	1	2	1	3	1	2	3	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:132740854C>T	uc004byw.1	-	4	454	c.235G>A	c.(235-237)GAA>AAA	p.E79K	FNBP1_uc011mbv.1_Missense_Mutation_p.E79K|FNBP1_uc011mbw.1_Missense_Mutation_p.E79K|FNBP1_uc004bza.2_Missense_Mutation_p.E79K|FNBP1_uc004byz.1_Missense_Mutation_p.E79K|FNBP1_uc004byx.1_5'UTR|FNBP1_uc004byy.1_5'UTR	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	79	Interaction with microtubules (By similarity).|Required for self-association and induction of membrane tubulation.|Self-association, lipid-binding and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		TCATTCATTTCGTTCAGGTTG	0.433			T	MLL	AML								7	50					0	0	0	0	T	132740854	T	T	132740854	3	4	150	1	0	0	0	0	1	0	0	0	5997	893	31	1	1674	1	FNBP1	9	132740854	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	31155236	132740854	8472577	52	27396											
SURF2	6835	broad.mit.edu	37	chr9	136226880	136226882	+	In_Frame_Del	DEL	GGA	-	-																															gcctgcctgcctggtgcaccGgaggaggaggagggaggacc																								rs149969130		TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:136226880_136226882delGGA	uc004cdi.2	+	4	440_442	c.392_394delGGA	c.(391-396)CGGAGG>CGG	p.131_132RR>R		NM_017503	NP_059973	Q15527	SURF2_HUMAN	surfeit 2	131_132							protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		CTGGTGCACCGGAGGAGGAGGAG	0.635													---	---	---								-	136226882	-	-	136226880	7	5	150	1	0	1	0	1	0	0	0	0	15470	1116	39	0	406	0	SURF2	9	136226880	In_Frame_Del	DEL	GGA	TCGA-CR-7382-01A-11D-2129-08	3486026	136226880	4986551	53	27397											
CACNA1B	774	broad.mit.edu	37	chr9	141016410	141016410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagctcgggtggccgagcaCggcacagctaccaccaccct	8	5	11	17	3	1	0	1	0	0	0	2	1	1	0	4	3	4	4	4	3	1	1			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr9:141016410C>T	uc004cog.2	+	46	7124	c.6979C>T	c.(6979-6981)CGG>TGG	p.R2327W	CACNA1B_uc004coi.2_Missense_Mutation_p.R1539W	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	2327	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGGCCGAGCACGGCACAGCTA	0.637													9	39					0	0	0	0	T	141016410	T	T	141016410	3	4	150	1	0	0	0	0	1	0	0	0	2551	527	19	1	7161	1	CACNA1B	9	141016410	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	4789530	141016410	197021	54	27398											
MYO3A	53904	broad.mit.edu	37	chr10	26463239	26463239	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaggaggaagaagataaagCagcggtattcattcagagca	16	6	12	7	1	2	3	2	0	0	3	2	5	2	5	1	3	3	3	1	3	5	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr10:26463239C>A	uc001isn.2	+	30	4406	c.4046C>A	c.(4045-4047)GCA>GAA	p.A1349E	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1349	IQ 3.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GAAGATAAAGCAGCGGTATTC	0.488													11	89					0.00829132	0.00850034	1	0	A	26463239	A	A	26463239	3	1	150	1	0	0	0	0	1	0	0	0	10129	710	25	4	4156	4	MYO3A	10	26463239	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08		26463239	109071508	55	27399											
CSGALNACT2	55454	broad.mit.edu	37	chr10	43650731	43650731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggaaatgcatctcttcCtggtgttgttggggaaaatt	9	15	12	5	0	1	1	0	1	1	0	3	3	2	3	1	4	1	3	1	4	3	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr10:43650731C>T	uc001jan.2	+	2	469	c.134C>T	c.(133-135)CCT>CTT	p.P45L	CSGALNACT2_uc001jam.1_Missense_Mutation_p.P45L	NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	45	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						GCATCTCTTCCTGGTGTTGTT	0.463													8	64					0	0	0	0	T	43650731	T	T	43650731	3	4	150	1	0	0	0	0	1	0	0	0	3956	681	24	4	136	4	CSGALNACT2	10	43650731	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	17187492	43650731	91884016	56	27400											
RHOBTB1	9886	broad.mit.edu	37	chr10	62648571	62648571	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatttggaagaagaggtagcGaggtaaattcgatgtgcaaa	16	9	13	3	2	0	2	0	0	0	2	1	5	0	3	0	3	2	3	0	3	7	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr10:62648571G>A	uc001jli.2	-	7	1293	c.855C>T	c.(853-855)CTC>CTT	p.L285L	RHOBTB1_uc001jlh.2_Silent_p.L285L|RHOBTB1_uc001jlj.2_Silent_p.L285L|RHOBTB1_uc001jlk.2_Silent_p.L285L|RHOBTB1_uc009xpe.1_Silent_p.L223L|RHOBTB1_uc001jll.2_Silent_p.L35L	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	285	BTB 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					AAGAGGTAGCGAGGTAAATTC	0.438													13	92					0	0	0	0	A	62648571	A	A	62648571	2	1	150	1	0	0	0	0	0	0	0	1	13398	1045	37	1		1	RHOBTB1	10	62648571	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08	18997840	62648571	72886176	57	27401											
SEC23IP	11196	broad.mit.edu	37	chr10	121685734	121685734	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatcttttgaagttggcgccGgacaggtgagtttacatatt	10	14	11	6	2	1	2	0	2	1	0	1	3	1	3	1	3	1	2	1	3	4	7			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr10:121685734G>A	uc001leu.1	+	13	2380	c.2308G>A	c.(2308-2310)GGA>AGA	p.G770R	SEC23IP_uc010qtc.1_Missense_Mutation_p.G559R|SEC23IP_uc009xzk.1_RNA	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	770					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding	p.G770R(1)		ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		AGTTGGCGCCGGACAGGTGAG	0.393													19	137					0	0	0	0	A	121685734	A	A	121685734	3	1	150	1	0	0	0	0	1	0	0	0	14058	1117	39	1	2358	1	SEC23IP	10	121685734	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	59037163	121685734	13849013	58	27402											
HRAS	3265	broad.mit.edu	37	chr11	534289	534289	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcactcttgcccacaccgcCggcgcccaccaccaccagct	7	4	7	23	4	1	0	0	0	1	0	1	0	1	0	7	1	2	2	7	1	0	1	rs104894229		TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr11:534289C>T	uc001lpv.2	-	2	222	c.34G>A	c.(34-36)GGC>AGC	p.G12S	HRAS_uc010qvw.1_Missense_Mutation_p.G12S|HRAS_uc010qvx.1_Missense_Mutation_p.G12S|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	12	GTP.		G -> S (in FCSS, OSCC and CMEMS).|G -> E (in FCSS).|G -> C (in FCSS).|G -> A (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12V(250)|p.G12S(54)|p.G12D(39)|p.G12C(23)|p.G12R(12)|p.G12A(7)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CCCACACCGCCGGCGCCCACC	0.647		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			56	46					0	0	0	0	T	534289	T	T	534289	3	4	150	1	0	0	0	0	1	0	0	0	7387	652	23	1	618	1	HRAS	11	534289	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08		534289	134472227	59	27403											
DDB1	1642	broad.mit.edu	37	chr11	61089130	61089130	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aattccattccggatgatccGcaaagaaccttccttgaaag	13	10	7	11	2	0	3	0	2	0	1	4	4	4	4	5	1	1	1	5	1	4	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr11:61089130G>A	uc001nrc.3	-	10	1388	c.1162C>T	c.(1162-1164)CGG>TGG	p.R388W	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Missense_Mutation_p.R388W|DDB1_uc010rlg.1_RNA|DDB1_uc001nrd.2_Missense_Mutation_p.R388W|DDB1_uc009ynl.1_Missense_Mutation_p.R275W	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	388	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						CGGATGATCCGCAAAGAACCT	0.473								NER					19	235					0	0	0	0	A	61089130	A	A	61089130	3	1	150	1	0	0	0	0	1	0	0	0	4340	1086	38	1	2332	1	DDB1	11	61089130	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	60554841	61089130	73917386	60	27404											
DDB1	1642	broad.mit.edu	37	chr11	61090509	61090509	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagctgggagtcacccaggcGagacccgacaaacacaacac	15	2	10	14	2	1	1	1	0	0	1	1	4	1	2	2	2	3	1	2	2	3	0			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr11:61090509G>A	uc001nrc.3	-	8	1205	c.979C>T	c.(979-981)CGC>TGC	p.R327C	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Missense_Mutation_p.R327C|DDB1_uc010rlg.1_RNA|DDB1_uc001nrd.2_Missense_Mutation_p.R327C|DDB1_uc009ynl.1_Missense_Mutation_p.R214C	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	327	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						TCACCCAGGCGAGACCCGACA	0.438								NER					3	31					0	0	0	0	A	61090509	A	A	61090509	3	1	150	1	0	0	0	0	1	0	0	0	4340	1058	37	1	2523	1	DDB1	11	61090509	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	1379	61090509	73916007	61	27405											
DDX10	1662	broad.mit.edu	37	chr11	108546344	108546344	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttgcaagaagctcagtaccGtttggtgactgagatacaga	12	11	11	7	1	1	4	1	2	0	3	1	5	1	4	1	1	4	4	1	1	4	4	rs145766863	byFrequency	TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr11:108546344G>A	uc001pkm.2	+	3	334	c.269G>A	c.(268-270)CGT>CAT	p.R90H	DDX10_uc001pkl.1_Missense_Mutation_p.R90H	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	90	Q motif.|ATP.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		GCTCAGTACCGTTTGGTGACT	0.393			T	NUP98	AML*								8	92					0	0	0	0	A	108546344	A	A	108546344	3	1	150	1	0	0	0	0	1	0	0	0	4359	1145	40	1	279	1	DDX10	11	108546344	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	47455835	108546344	26460172	62	27406											
OR6M1	390261	broad.mit.edu	37	chr11	123676267	123676267	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaccttgtcataatccagtGaggagttctgattgggtctc	8	13	10	10	0	3	2	1	2	2	0	5	3	4	3	3	2	0	1	3	2	1	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr11:123676267G>A	uc010rzz.1	-	1	791	c.791C>T	c.(790-792)TCA>TTA	p.S264L		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		ATAATCCAGTGAGGAGTTCTG	0.488													8	66					0	0	0	0	A	123676267	A	A	123676267	3	1	150	1	0	0	0	0	1	0	0	0	11259	1294	45	2	153	2	OR6M1	11	123676267	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	15129923	123676267	11330249	63	27407											
PRB3	5544	broad.mit.edu	37	chr12	11420574	11420574	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggggtggtccttctggCtttcccggacgaggtggggg	2	11	20	8	2	1	0	0	0	1	0	3	2	3	1	2	8	0	1	2	8	0	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:11420574C>A	uc001qzs.2	-	3	647	c.609G>T	c.(607-609)AAG>AAT	p.K203N	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	203	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|8.|Pro-rich.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GTCCTTCTGGCTTTCCCGGAC	0.627													10	272					1.40151e-16	1.52664e-16	1	0	A	11420574	A	A	11420574	3	1	150	1	0	0	0	0	1	0	0	0	12506	796	28	4	328	4	PRB3	12	11420574	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08		11420574	122431321	64	27408											
PRB3	5544	broad.mit.edu	37	chr12	11420826	11420826	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggggtggtccttctggCtttcccggacgaggtggggg	2	11	20	8	2	1	0	0	0	1	0	3	2	3	1	2	8	0	1	2	8	0	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:11420826C>A	uc001qzs.2	-	3	395	c.357G>T	c.(355-357)AAG>AAT	p.K119N	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	119	4.|10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.			K -> E (in Ref. 1; CAA30728).		extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GTCCTTCTGGCTTTCCCGGAC	0.632													18	195					5.77227e-19	6.3443e-19	1	0	A	11420826	A	A	11420826	3	1	150	1	0	0	0	0	1	0	0	0	12506	796	28	4	580	4	PRB3	12	11420826	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	252	11420826	122431069	65	27409											
PUS7L	83448	broad.mit.edu	37	chr12	44148576	44148576	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcctattgagaattcaggaGgtagtccaattagctctgtt	10	14	10	7	0	2	1	1	1	1	1	3	3	3	2	2	2	2	3	2	2	5	6			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:44148576G>A	uc001rnq.3	-	2	962	c.473C>T	c.(472-474)CCT>CTT	p.P158L	PUS7L_uc001rnr.3_Missense_Mutation_p.P158L|PUS7L_uc001rns.3_Missense_Mutation_p.P158L|PUS7L_uc009zkb.2_Intron	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	158					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		GAATTCAGGAGGTAGTCCAAT	0.368													10	120					0	0	0	0	A	44148576	A	A	44148576	3	1	150	1	0	0	0	0	1	0	0	0	12899	1000	35	4	1664	4	PUS7L	12	44148576	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	32727750	44148576	89703319	66	27410											
ARHGAP9	64333	broad.mit.edu	37	chr12	57867414	57867414	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgctccaggaggtaccgtaGagtgtcatggttgggctttg	7	12	15	7	1	1	1	1	0	0	1	2	2	2	2	2	4	2	5	2	4	2	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:57867414G>C	uc001sod.2	-	20	2459	c.2266C>G	c.(2266-2268)CTA>GTA	p.L756V	ARHGAP9_uc001sny.2_RNA|ARHGAP9_uc001snz.2_Missense_Mutation_p.L482V|ARHGAP9_uc001soa.2_Missense_Mutation_p.L355V|ARHGAP9_uc001sob.2_Intron|ARHGAP9_uc001soc.2_Missense_Mutation_p.L666V	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	685	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			AGGTACCGTAGAGTGTCATGG	0.507													12	109					0	0	0	0	C	57867414	C	C	57867414	3	2	150	1	0	0	0	0	1	0	0	0	889	933	33	2	207	2	ARHGAP9	12	57867414	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	13718838	57867414	75984481	67	27411			1	41		2	2	27	G		8.48245e-05
ARHGAP9	64333	broad.mit.edu	37	chr12	57867440	57867440	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catggttgggctttggcattGagcctattaattcttgtatc	7	17	10	7	0	1	1	0	1	1	0	2	1	1	1	1	3	1	4	1	3	3	8			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:57867440G>C	uc001sod.2	-	20	2433	c.2240C>G	c.(2239-2241)TCA>TGA	p.S747*	ARHGAP9_uc001sny.2_RNA|ARHGAP9_uc001snz.2_Nonsense_Mutation_p.S473*|ARHGAP9_uc001soa.2_Nonsense_Mutation_p.S346*|ARHGAP9_uc001sob.2_Intron|ARHGAP9_uc001soc.2_Nonsense_Mutation_p.S657*	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	676	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			CTTTGGCATTGAGCCTATTAA	0.488													10	92					0	0	0	0	C	57867440	C	C	57867440	4	2	150	1	0	0	0	0	0	1	0	0	889	1294	45	2	233	2	ARHGAP9	12	57867440	Nonsense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	26	57867440	75984455	68	27412			1	41		2	2	27	G		8.48245e-05
GNS	2799	broad.mit.edu	37	chr12	65130831	65130831	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggtcctcgaaccaacagtgGaactttgatatcaaactcat	14	10	7	10	1	2	1	2	1	0	0	4	3	3	2	2	2	4	0	2	2	5	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr12:65130831G>A	uc001ssg.3	-	9	1221	c.1051C>T	c.(1051-1053)CCA>TCA	p.P351S	GNS_uc001ssf.2_Missense_Mutation_p.P295S|GNS_uc010ssq.1_Missense_Mutation_p.P383S|GNS_uc010ssr.1_Missense_Mutation_p.P331S	NM_002076	NP_002067	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase precursor	351						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		ACCAACAGTGGAACTTTGATA	0.458													5	73					0	0	0	0	A	65130831	A	A	65130831	3	1	150	1	0	0	0	0	1	0	0	0	6587	1174	41	2	631	2	GNS	12	65130831	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	7263391	65130831	68721064	69	27413											
ATP11A	23250	broad.mit.edu	37	chr13	113508638	113508638	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgaggccctgcagaaggcCgggatcaaagtctgggttct	9	8	14	10	2	3	1	1	0	2	1	4	3	3	2	2	4	1	2	2	4	2	1	rs144429120		TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr13:113508638C>T	uc001vsi.3	+	19	2125	c.2037C>T	c.(2035-2037)GCC>GCT	p.A679A	ATP11A_uc001vsj.3_Silent_p.A679A|ATP11A_uc001vsm.1_Silent_p.A555A|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	679	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TGCAGAAGGCCGGGATCAAAG	0.592													5	57					0	0	0	0	T	113508638	T	T	113508638	2	4	150	1	0	0	0	0	0	0	0	1	1121	639	23	1		1	ATP11A	13	113508638	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08		113508638	1661240	70	27414											
FSIP1	161835	broad.mit.edu	37	chr15	40068654	40068654	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaagaagcatttgaacttctGctcccagggcgtattcttga	11	12	9	9	1	2	3	0	2	2	1	3	3	3	3	1	1	3	3	1	1	4	5			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr15:40068654G>T	uc001zki.2	-	2	290	c.72C>A	c.(70-72)AGC>AGA	p.S24R		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	24										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		TTGAACTTCTGCTCCCAGGGC	0.368													10	146					4.68919e-08	5.06266e-08	1	0	T	40068654	T	T	40068654	3	4	150	1	0	0	0	0	1	0	0	0	6108	1310	46	4	1717	4	FSIP1	15	40068654	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08		40068654	62462738	71	27415											
B2M	567	broad.mit.edu	37	chr15	45003745	45003745	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacagcattcgggccgagAtgtctcgctccgtggcctta	6	10	12	13	4	1	2	0	1	1	1	4	3	2	2	3	2	1	2	3	2	1	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr15:45003745A>G	uc001zuc.2	+	1	61	c.1A>G	c.(1-3)ATG>GTG	p.M1V	B2M_uc010uek.1_Missense_Mutation_p.M1V|B2M_uc010bdx.1_Missense_Mutation_p.M1V	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	1					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.M1V(2)		ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		TCGGGCCGAGATGTCTCGCTC	0.612													5	74					0	0	0	0	G	45003745	G	G	45003745	3	3	150	1	0	0	0	0	1	0	0	0	1246	333	12	5	3	5	B2M	15	45003745	Missense_Mutation	SNP	A	TCGA-CR-7382-01A-11D-2129-08	4935091	45003745	57527647	72	27416											
HERC1	8925	broad.mit.edu	37	chr15	63942010	63942010	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccagagatccatccatcCgtcccaccaacaacaattct	12	8	4	17	1	1	1	0	0	1	1	6	2	6	1	6	0	2	0	6	0	3	1			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr15:63942010C>T	uc002amp.2	-	54	10809	c.10661G>A	c.(10660-10662)CGG>CAG	p.R3554Q		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3554	WD 6.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TCCATCCATCCGTCCCACCAA	0.512													7	23					0	0	0	0	T	63942010	T	T	63942010	3	4	150	1	0	0	0	0	1	0	0	0	7096	652	23	1	4024	1	HERC1	15	63942010	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	18938265	63942010	38589382	73	27417											
LBXCOR1	390598	broad.mit.edu	37	chr15	68118861	68118861	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcgcaccgaacacccgacgCcaagtacacgcagcccgatg	11	3	9	18	6	0	0	0	0	0	0	1	3	0	0	4	0	3	3	4	0	3	1			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr15:68118861C>T	uc002aqy.1	+	2	668	c.668C>T	c.(667-669)GCC>GTC	p.A223V		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	232					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						ACACCCGACGCCAAGTACACG	0.567													7	57					0	0	0	0	T	68118861	T	T	68118861	3	4	150	1	0	0	0	0	1	0	0	0	8695	739	26	4	674	4	LBXCOR1	15	68118861	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	4176851	68118861	34412531	74	27418											
CHD2	1106	broad.mit.edu	37	chr15	93518123	93518123	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacagcgtctggatggttcCatcaagggagaaatccgaaa	13	9	11	8	2	2	1	1	0	1	1	4	4	4	2	2	3	2	1	2	3	4	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr15:93518123C>A	uc002bsp.2	+	20	3095	c.2520C>A	c.(2518-2520)TCC>TCA	p.S840S	CHD2_uc002bso.1_Silent_p.S840S|CHD2_uc010bog.1_Silent_p.S85S|CHD2_uc010boh.1_Silent_p.S34S	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	840	Helicase C-terminal.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TGGATGGTTCCATCAAGGGAG	0.433													11	62					0.000308642	0.000321832	1	0	A	93518123	A	A	93518123	2	1	150	1	0	0	0	0	0	0	0	1	3340	581	21	4		4	CHD2	15	93518123	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08	25399262	93518123	9013269	75	27419											
RHBDL1	9028	broad.mit.edu	37	chr16	727018	727019	+	Missense_Mutation	DNP	GC	AA	AA																															cgcctcaacaagtgggtgctGcagacctaccaccccgagta																										TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr16:727018_727019GC>AA	uc002cis.1	+	3	696_697	c.669_670GC>AA	c.(667-672)CTGCAG>CTAAAG	p.Q224K	RHBDL1_uc002cir.1_Missense_Mutation_p.Q159K|RHBDL1_uc010uun.1_Missense_Mutation_p.Q159K	NM_003961	NP_003952	O75783	RHBL1_HUMAN	rhomboid protease 1	224					proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.0218)				AGTGGGTGCTGCAGACCTACCA	0.639													8	63					0	0	0	0	AA	727019	AA	AA	727018	3	1	150	1	0	0	0	0	1	0	0	0	13386	1306	46	4	679	4	RHBDL1	16	727018	Missense_Mutation	DNP	GC	TCGA-CR-7382-01A-11D-2129-08		727018	89627735	76	27420											
PLEKHG4	25894	broad.mit.edu	37	chr16	67318871	67318871	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgaggcttcactgaagctaCcaccggtgggcagcacagct	9	8	12	12	1	1	2	1	2	0	0	1	2	1	2	2	3	4	5	2	3	2	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr16:67318871C>A	uc002eso.3	+	12	4483	c.1948C>A	c.(1948-1950)CCA>ACA	p.P650T	PLEKHG4_uc002esp.3_Missense_Mutation_p.P457T|PLEKHG4_uc002esq.3_Missense_Mutation_p.P650T|PLEKHG4_uc010cef.2_Missense_Mutation_p.P650T|PLEKHG4_uc002ess.3_Missense_Mutation_p.P650T|PLEKHG4_uc010ceg.2_Missense_Mutation_p.P569T	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	650					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		ACTGAAGCTACCACCGGTGGG	0.667													6	28					0.00198382	0.00205107	1	0	A	67318871	A	A	67318871	3	1	150	1	0	0	0	0	1	0	0	0	12126	507	18	4	1994	4	PLEKHG4	16	67318871	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	66591853	67318871	23035882	77	27421											
CTCF	10664	broad.mit.edu	37	chr16	67650717	67650717	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagaattggttcggcatcGtcgttacaaacacacccacg	11	9	10	11	4	0	1	0	0	0	1	3	2	0	1	1	3	2	3	1	3	3	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr16:67650717G>A	uc002etl.2	+	5	1312	c.1022G>A	c.(1021-1023)CGT>CAT	p.R341H	CTCF_uc010cek.2_Missense_Mutation_p.R13H	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	341	C2H2-type 3.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		GTTCGGCATCGTCGTTACAAA	0.488													26	276					0	0	0	0	A	67650717	A	A	67650717	3	1	150	1	0	0	0	0	1	0	0	0	4017	1145	40	1	1032	1	CTCF	16	67650717	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	331846	67650717	22704036	78	27422											
PRMT7	54496	broad.mit.edu	37	chr16	68382250	68382250	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttttctttctaagatcttCaaggctaaccacttggaaga	11	14	8	8	0	4	2	1	0	3	2	4	3	4	3	1	3	1	2	1	3	4	7			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr16:68382250C>G	uc002evy.1	+	14	1605	c.1329C>G	c.(1327-1329)TTC>TTG	p.F443L	PRMT7_uc002evx.1_Intron|PRMT7_uc010vlg.1_Missense_Mutation_p.F393L|PRMT7_uc002evz.1_Intron	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	443					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CTAAGATCTTCAAGGCTAACC	0.373													8	84					0	0	0	0	G	68382250	G	G	68382250	3	3	150	1	0	0	0	0	1	0	0	0	12603	825	29	2	1375	2	PRMT7	16	68382250	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	731533	68382250	21972503	79	27423											
ZNF594	84622	broad.mit.edu	37	chr17	5085805	5085805	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttacctgatgtctgatgaGgtctgagctgccctggaaag	9	11	13	8	0	2	4	0	4	2	0	2	5	2	5	2	2	3	2	2	2	2	1			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:5085805G>C	uc010cla.1	-	2	1903	c.1747C>G	c.(1747-1749)CTC>GTC	p.L583V		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	583	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TGTCTGATGAGGTCTGAGCTG	0.458													17	198					0	0	0	0	C	5085805	C	C	5085805	3	2	150	1	0	0	0	0	1	0	0	0	18091	1000	35	4	680	4	ZNF594	17	5085805	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08		5085805	76109405	80	27424											
MYH4	4622	broad.mit.edu	37	chr17	10354168	10354168	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtttgcctcgggatagctGagaaaccatagcatcttttt	9	15	9	8	1	1	1	0	1	1	1	2	3	1	2	2	1	4	3	2	1	3	6			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:10354168G>A	uc002gmn.2	-	29	4021	c.3910C>T	c.(3910-3912)CAG>TAG	p.Q1304*	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1304	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CGGGATAGCTGAGAAACCATA	0.383													20	110					0	0	0	0	A	10354168	A	A	10354168	4	1	150	1	0	0	0	0	0	1	0	0	10090	1299	45	2	1957	2	MYH4	17	10354168	Nonsense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	5268363	10354168	70841042	81	27425											
STAT5B	6777	broad.mit.edu	37	chr17	40359614	40359614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaactggtgtgtagtatttgGagtatacttcatcttttggc	8	17	11	5	0	2	0	1	0	1	0	2	2	2	1	0	3	2	3	0	3	5	8			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:40359614G>A	uc002hzh.2	-	16	2208	c.2039C>T	c.(2038-2040)TCC>TTC	p.S680F		NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	680	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GTAGTATTTGGAGTATACTTC	0.388													18	145					0	0	0	0	A	40359614	A	A	40359614	3	1	150	1	0	0	0	0	1	0	0	0	15335	1174	41	2	340	2	STAT5B	17	40359614	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	30005446	40359614	40835596	82	27426											
EZH1	2145	broad.mit.edu	37	chr17	40854917	40854917	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtaatcaaagaagagctcttCgccagcttgaattgccctct	11	11	8	11	1	3	3	1	1	2	2	4	3	3	3	2	0	3	3	2	0	4	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:40854917C>T	uc002iaz.2	-	20	2306	c.2161G>A	c.(2161-2163)GAA>AAA	p.E721K	EZH1_uc002iba.2_Missense_Mutation_p.E712K|EZH1_uc010wgt.1_Missense_Mutation_p.E651K|EZH1_uc010wgu.1_Missense_Mutation_p.E727K|EZH1_uc010wgv.1_Missense_Mutation_p.E681K|EZH1_uc010wgw.1_Missense_Mutation_p.E582K	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	721	SET.			VVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGI ERETDVL -> GESQ (in Ref. 2; BAA25019).	anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding	p.E721K(1)		ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		AAGAGCTCTTCGCCAGCTTGA	0.512													20	196					0	0	0	0	T	40854917	T	T	40854917	3	4	150	1	0	0	0	0	1	0	0	0	5358	893	31	1	90	1	EZH1	17	40854917	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	495303	40854917	40340293	83	27427											
OTOP2	92736	broad.mit.edu	37	chr17	72926892	72926892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatctcttactactccatcGtggctgtggtggcgggcaca	6	11	11	13	2	1	0	0	0	1	0	4	0	2	0	2	4	2	2	2	4	2	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr17:72926892G>A	uc010wrp.1	+	7	1251	c.1162G>A	c.(1162-1164)GTG>ATG	p.V388M		NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	388	Helical; (Potential).					integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					CTACTCCATCGTGGCTGTGGT	0.617													6	63					0	0	0	0	A	72926892	A	A	72926892	3	1	150	1	0	0	0	0	1	0	0	0	11360	1145	40	1	1180	1	OTOP2	17	72926892	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	32071975	72926892	8268318	84	27428											
EPB41L3	23136	broad.mit.edu	37	chr18	5489117	5489117	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcgcccctgcgcccccgcCgcctcctggggctcggcctc	0	5	13	23	6	0	0	0	0	0	0	3	0	1	0	8	3	1	1	8	3	0	0			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr18:5489117C>T	uc002kmt.1	-	2	152	c.66G>A	c.(64-66)GCG>GCA	p.A22A	EPB41L3_uc010wzh.1_Silent_p.A22A|EPB41L3_uc002kmu.1_Silent_p.A22A|EPB41L3_uc010dkq.1_5'UTR|EPB41L3_uc010dks.1_Silent_p.A44A|EPB41L3_uc002kmv.1_5'UTR	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	22					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						gcgcccccgccgccTCCTGGG	0.512													3	27					0	0	0	0	T	5489117	T	T	5489117	2	4	150	1	0	0	0	0	0	0	0	1	5178	639	23	1		1	EPB41L3	18	5489117	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08		5489117	72588131	85	27429											
ANKRD12	23253	broad.mit.edu	37	chr18	9255584	9255584	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataaaagatctaaaagaagaGagagaaaacatacccacaga	24	4	7	6	0	1	5	0	0	1	5	1	7	1	5	1	0	2	0	1	0	8	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr18:9255584G>C	uc002knv.2	+	9	2576	c.2319G>C	c.(2317-2319)GAG>GAC	p.E773D	ANKRD12_uc002knw.2_Missense_Mutation_p.E750D|ANKRD12_uc002knx.2_Missense_Mutation_p.E750D|ANKRD12_uc010dkx.1_Missense_Mutation_p.E480D	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	773						nucleus				ovary(2)|central_nervous_system(1)	3						TAAAAGAAGAGAGAGAAAACA	0.348													7	64					0	0	0	0	C	9255584	C	C	9255584	3	2	150	1	0	0	0	0	1	0	0	0	640	933	33	2	2349	2	ANKRD12	18	9255584	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	3766467	9255584	68821664	86	27430											
SMAD4	4089	broad.mit.edu	37	chr18	48573554	48573554	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgaaagtttggtaaagaaGctgaaggagaaaaaagatga	20	8	12	1	0	0	6	0	3	0	3	0	7	0	6	0	2	1	3	0	2	8	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr18:48573554G>A	uc010xdp.1	+	2	676	c.138G>A	c.(136-138)AAG>AAA	p.K46K	SMAD4_uc010xdo.1_RNA	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	46	MH1.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(5)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		TGGTAAAGAAGCTGAAGGAGA	0.368									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				7	86					0	0	0	0	A	48573554	A	A	48573554	2	1	150	1	0	0	0	0	0	0	0	1	14824	962	34	4		4	SMAD4	18	48573554	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08	39317970	48573554	29503694	87	27431											
DSEL	92126	broad.mit.edu	37	chr18	65178325	65178325	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattagtattagttggtgatAtttccccttcatagggaagg	10	15	10	6	0	1	1	1	1	0	0	2	2	2	2	2	3	0	2	2	3	6	8			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr18:65178325A>G	uc002lke.1	-	2	4775	c.3551T>C	c.(3550-3552)ATA>ACA	p.I1184T		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1174						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				AGTTGGTGATATTTCCCCTTC	0.363													10	66					0	0	0	0	G	65178325	G	G	65178325	3	3	150	1	0	0	0	0	1	0	0	0	4797	449	16	5	121	5	DSEL	18	65178325	Missense_Mutation	SNP	A	TCGA-CR-7382-01A-11D-2129-08	16604771	65178325	12898923	88	27432											
ZNF407	55628	broad.mit.edu	37	chr18	72344099	72344099	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttggtctagctcagaatcCtgaaaaccagagtagaaagc	14	8	9	10	0	2	4	1	1	1	3	3	4	3	4	3	1	3	2	3	1	6	3			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr18:72344099C>A	uc002llw.2	+	1	1181	c.1124C>A	c.(1123-1125)CCT>CAT	p.P375H	ZNF407_uc010xfc.1_Missense_Mutation_p.P375H|ZNF407_uc010dqu.1_Missense_Mutation_p.P375H|ZNF407_uc002llu.2_Missense_Mutation_p.P374H	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	375					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GCTCAGAATCCTGAAAACCAG	0.413													6	82					0.000157383	0.000165524	1	0	A	72344099	A	A	72344099	3	1	150	1	0	0	0	0	1	0	0	0	17954	681	24	4	1126	4	ZNF407	18	72344099	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	7165774	72344099	5733149	89	27433											
ATCAY	85300	broad.mit.edu	37	chr19	3920766	3920766	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgtctctcctccacaggtCtgctctggtctcagaagatc	6	12	8	15	1	4	2	1	0	4	2	10	2	7	2	3	2	1	1	3	2	1	0			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:3920766C>G	uc002lyy.3	+	12	1506	c.1076C>G	c.(1075-1077)TCT>TGT	p.S359C	ATCAY_uc010xhz.1_Missense_Mutation_p.S365C|ATCAY_uc010dts.2_Missense_Mutation_p.S116C	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	359					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		CTCCACAGGTCTGCTCTGGTC	0.378													4	34					0	0	0	0	G	3920766	G	G	3920766	3	3	150	1	0	0	0	0	1	0	0	0	1079	913	32	2	1118	2	ATCAY	19	3920766	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08		3920766	55208217	90	27434											
PLIN3	10226	broad.mit.edu	37	chr19	4847853	4847853	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagctctgttcctgccgctgCtgctgcacggacgcgacgtc	4	10	12	15	5	1	0	0	0	1	0	3	2	2	1	2	1	5	6	2	1	1	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:4847853C>T	uc002mbj.2	-	6	861	c.684G>A	c.(682-684)CAG>CAA	p.Q228Q	PLIN3_uc002mbk.2_Silent_p.Q216Q|PLIN3_uc002mbl.3_Silent_p.Q228Q	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	228					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	CCTGCCGCTGCTGCTGCACGG	0.617													3	23					0	0	0	0	T	4847853	T	T	4847853	2	4	150	1	0	0	0	0	0	0	0	1	12146	796	28	4		4	PLIN3	19	4847853	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08	927087	4847853	54281130	91	27435											
HNRNPM	4670	broad.mit.edu	37	chr19	8551952	8551952	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgctaaaggacaaattcaaCgagtgcggtaagtgttggga	14	9	13	5	2	1	0	1	0	0	0	1	3	1	2	0	3	3	3	0	3	5	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:8551952C>T	uc010dwe.2	+	15	2102	c.2022C>T	c.(2020-2022)AAC>AAT	p.N674N	HNRNPM_uc010dwd.2_Silent_p.N635N|HNRNPM_uc002mka.2_Silent_p.N539N|HNRNPM_uc002mkb.1_5'Flank	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	674	RRM 3.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						ACAAATTCAACGAGTGCGGTA	0.517													18	142					0	0	0	0	T	8551952	T	T	8551952	2	4	150	1	0	0	0	0	0	0	0	1	7310	535	19	1		1	HNRNPM	19	8551952	Silent	SNP	C	TCGA-CR-7382-01A-11D-2129-08	3704099	8551952	50577031	92	27436											
CACNA1A	773	broad.mit.edu	37	chr19	13414687	13414687	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacctcgttccagtcttcGcccgtcaggatctgaaaggg	8	10	11	12	3	3	2	1	2	2	0	6	3	4	3	3	2	0	1	3	2	1	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:13414687G>A	uc010dze.2	-	16	2237	c.2001C>T	c.(1999-2001)GGC>GGT	p.G667G	CACNA1A_uc010dzc.2_Silent_p.G192G|CACNA1A_uc002mwy.3_Silent_p.G666G|CACNA1A_uc010xne.1_Silent_p.G192G	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	667	Extracellular (Potential).|II.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCCAGTCTTCGCCCGTCAGGA	0.592													18	159					0	0	0	0	A	13414687	A	A	13414687	2	1	150	1	0	0	0	0	0	0	0	1	2550	1074	38	1		1	CACNA1A	19	13414687	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08	4862735	13414687	45714296	93	27437											
ZNF302	55900	broad.mit.edu	37	chr19	35173684	35173684	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatatttgctatttcaggtGacatttagtgatgtggctat	10	18	9	4	0	1	2	1	2	0	0	1	2	1	2	0	2	1	2	0	2	5	8	rs149807567	by1000genomes	TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:35173684G>A	uc002nvr.1	+	4	407	c.144G>A	c.(142-144)GTG>GTA	p.V48V	ZNF302_uc010xrz.1_Silent_p.V4V|ZNF302_uc002nvp.1_Silent_p.V4V|ZNF302_uc002nvq.1_Silent_p.V4V|ZNF302_uc002nvs.1_Silent_p.V4V	NM_018443	NP_060913	Q9NR11	ZN302_HUMAN	zinc finger protein 302	Error:Variant_position_missing_in_Q9NR11_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TATTTCAGGTGACATTTAGTG	0.433													7	64					0	0	0	0	A	35173684	A	A	35173684	2	1	150	1	0	0	0	0	0	0	0	1	17899	1277	45	2		2	ZNF302	19	35173684	Silent	SNP	G	TCGA-CR-7382-01A-11D-2129-08	21758997	35173684	23955299	94	27438											
TRAPPC6A	79090	broad.mit.edu	37	chr19	45681407	45681407	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gctcacccccgggccggggtCggggtcgtgagcccacagct	4	5	16	16	4	1	1	1	1	0	0	3	1	1	1	4	5	2	2	4	5	0	0			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:45681407C>G	uc002paw.2	-	1	89	c.70G>C	c.(70-72)GAC>CAC	p.D24H	TRAPPC6A_uc002pav.2_Missense_Mutation_p.D24H|BLOC1S3_uc002pax.3_5'Flank			O75865	TPC6A_HUMAN	SubName: Full=TRAPPC6Adelta29-42; SubName: Full=Trafficking protein particle complex 6A, isoform CRA_a;	24					vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	guanylate cyclase activity|heme binding				0		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00872)|GBM - Glioblastoma multiforme(486;0.233)		GGGCCGGGGTCGGGGTCGTGA	0.627													5	43					0	0	0	0	G	45681407	G	G	45681407	3	3	150	1	0	0	0	0	1	0	0	0	16530	884	31	3	475	3	TRAPPC6A	19	45681407	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	10507723	45681407	13447576	95	27439											
PPP2R1A	5518	broad.mit.edu	37	chr19	52715983	52715983	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgacacccccatggtgcggcGggccgcagcctccaagctgg	6	5	14	16	3	0	1	0	1	0	0	1	1	1	1	5	4	3	2	5	4	1	0			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:52715983G>A	uc002pyp.2	+	5	707	c.548G>A	c.(547-549)CGG>CAG	p.R183Q	PPP2R1A_uc010ydk.1_Missense_Mutation_p.R128Q|PPP2R1A_uc010epm.1_Missense_Mutation_p.R223Q|PPP2R1A_uc002pyq.2_Missense_Mutation_p.R4Q	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	183	PP2A subunit B binding.|SV40 small T antigen binding.|HEAT 5.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.R183W(16)|p.R183Q(7)|p.R183G(2)		endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		ATGGTGCGGCGGGCCGCAGCC	0.562			Mis		clear cell ovarian carcinoma								15	66					0	0	0	0	A	52715983	A	A	52715983	3	1	150	1	0	0	0	0	1	0	0	0	12442	1116	39	1	566	1	PPP2R1A	19	52715983	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	7034576	52715983	6413000	96	27440											
NLRP5	126206	broad.mit.edu	37	chr19	56539838	56539838	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaagggatcttcccaagaGatgagtccgctgaggcatgt	11	9	12	9	1	2	3	1	2	1	1	4	5	4	4	2	2	0	2	2	2	2	1			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr19:56539838G>C	uc002qmj.2	+	7	2239	c.2239G>C	c.(2239-2241)GAT>CAT	p.D747H	NLRP5_uc002qmi.2_Missense_Mutation_p.D728H	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	747	LRR 2.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTTCCCAAGAGATGAGTCCGC	0.517													20	209					0	0	0	0	C	56539838	C	C	56539838	3	2	150	1	0	0	0	0	1	0	0	0	10534	942	33	2	2265	2	NLRP5	19	56539838	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	3823855	56539838	2589145	97	27441											
C20orf94	128710	broad.mit.edu	37	chr20	10604013	10604013	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaagaaaagaaagaaatacGaaagaggccattaacaccga	22	3	8	8	2	0	4	0	0	0	4	0	6	0	4	3	1	2	0	3	1	8	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr20:10604013G>A	uc010zre.1	+	8	1393	c.1213G>A	c.(1213-1215)GAA>AAA	p.E405K		NM_001009608	NP_001009608	Q5VYV7	CT094_HUMAN	hypothetical protein LOC128710	405							protein binding				0						AAAGAAATACGAAAGAGGCCA	0.448													6	63					0	0	0	0	A	10604013	A	A	10604013	3	1	150	1	0	0	0	0	1	0	0	0	2131	1059	37	1	1239	1	C20orf94	20	10604013	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08		10604013	52421507	98	27442											
SEC23B	10483	broad.mit.edu	37	chr20	18491571	18491571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttccagccggctggaggCtacaagaatggttgtacccc	8	8	12	13	1	0	1	0	0	0	1	1	2	1	2	5	4	3	4	5	4	4	4			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr20:18491571C>T	uc002wqz.1	+	2	535	c.92C>T	c.(91-93)GCT>GTT	p.A31V	SEC23B_uc002wra.1_Missense_Mutation_p.A31V|SEC23B_uc002wrb.1_Missense_Mutation_p.A31V|SEC23B_uc010zsb.1_Missense_Mutation_p.A31V|SEC23B_uc002wrc.1_Missense_Mutation_p.A31V	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	31					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						CGGCTGGAGGCTACAAGAATG	0.502													8	103					0	0	0	0	T	18491571	T	T	18491571	3	4	150	1	0	0	0	0	1	0	0	0	14057	797	28	4	94	4	SEC23B	20	18491571	Missense_Mutation	SNP	C	TCGA-CR-7382-01A-11D-2129-08	7887558	18491571	44533949	99	27443											
ATP9A	10079	broad.mit.edu	37	chr20	50255990	50255990	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctcagctgcatggaagactgGtctcggcccaccagggttaa	9	8	12	12	1	2	1	1	0	1	1	3	2	2	2	2	4	2	3	2	4	2	1			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr20:50255990G>C	uc002xwg.1	-	15	1560	c.1560C>G	c.(1558-1560)GAC>GAG	p.D520E	ATP9A_uc010gih.1_Missense_Mutation_p.D384E|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	520	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TGGAAGACTGGTCTCGGCCCA	0.542											OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	89					0	0	0	0	C	50255990	C	C	50255990	3	2	150	1	0	0	0	0	1	0	0	0	1200	1252	44	4	1639	4	ATP9A	20	50255990	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08	31764419	50255990	12769530	100	27444											
MOV10L1	54456	broad.mit.edu	37	chr22	50580618	50580618	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgcagagatgagcgattggGgtatgtgctcatgaggggca	9	9	17	6	1	1	3	1	2	0	1	1	5	1	3	0	4	3	4	0	4	1	2			TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chr22:50580618G>A	uc003bjj.2	+	16	2262	c.2179G>A	c.(2179-2181)GTA>ATA	p.V727I	MOV10L1_uc003bjk.3_Missense_Mutation_p.V727I|MOV10L1_uc011arp.1_Missense_Mutation_p.V707I|MOV10L1_uc011arq.1_Missense_Mutation_p.V488I|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	727					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GAGCGATTGGGGTATGTGCTC	0.547											OREG0026672	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	36					0	0	0	0	A	50580618	A	A	50580618	3	1	150	1	0	0	0	0	1	0	0	0	9772	1246	43	4	2282	4	MOV10L1	22	50580618	Missense_Mutation	SNP	G	TCGA-CR-7382-01A-11D-2129-08		50580618	723948	101	27445											
RBM10	8241	broad.mit.edu	37	chrX	47030561	47030563	+	In_Frame_Del	DEL	GGA	-	-																															gactatcggaccgagcaaggGgaggaggaggaggaggagga																										TCGA-CR-7382-01A-11D-2129-08	TCGA-CR-7382-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdde6828-b9f4-4648-a86b-157c5d46abb2	51cea5c6-365a-4c91-90c1-05a2619bfdf4	g.chrX:47030561_47030563delGGA	uc004dhf.2	+	4	715_717	c.336_338delGGA	c.(334-339)GGGGAG>GGG	p.E119del	RBM10_uc004dhe.1_In_Frame_Del_p.E109del|RBM10_uc004dhg.2_Intron|RBM10_uc004dhh.2_In_Frame_Del_p.E119del|RBM10_uc010nhq.2_Intron|RBM10_uc004dhi.2_In_Frame_Del_p.E184del	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	119	Poly-Glu.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						CCGAGCAAGGggaggaggaggag	0.522													---	---	---								-	47030563	-	-	47030561	7	5	150	1	0	1	0	1	0	0	0	0	13176	1219	43	0	346	0	RBM10	23	47030561	In_Frame_Del	DEL	GGA	TCGA-CR-7382-01A-11D-2129-08		47030561	108239999	102	27446											
AIM1L	55057	broad.mit.edu	37	chr1	26663842	26663842	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagatactggtggccccGgaagccctccttctcgtagc	7	8	11	15	2	1	1	0	0	1	1	3	2	2	2	4	3	4	2	4	3	3	3	rs145909949	by1000genomes	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:26663842G>A	uc001bmd.3	-	9	968	c.538C>T	c.(538-540)CGG>TGG	p.R180W	AIM1L_uc001bmf.3_Missense_Mutation_p.R71W	NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	180	Beta/gamma crystallin 'Greek key' 4.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		TGGTGGCCCCGGAAGCCCTCC	0.607													5	72					0	0	0	0	A	26663842	A	A	26663842	3	1	151	1	0	0	0	0	1	0	0	0	431	1115	39	1	1356	1	AIM1L	1	26663842	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08		26663842	222586779	1	27447											
LCK	3932	broad.mit.edu	37	chr1	32740034	32740034	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccactggatggcaagggcaCggtaagaggcgagacagggg	11	3	18	9	2	0	2	0	0	0	2	0	4	0	3	1	7	0	3	1	7	2	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:32740034C>T	uc001bux.2	+	2	242	c.104C>T	c.(103-105)ACG>ATG	p.T35M	LCK_uc001buy.2_Missense_Mutation_p.T35M|LCK_uc001buz.2_Missense_Mutation_p.T35M|LCK_uc010ohc.1_Missense_Mutation_p.T79M|LCK_uc001bva.2_Missense_Mutation_p.T35M	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	35	Interactions with CD4 and CD8 (By similarity).			T -> R (in Ref. 2; AAA59502).	activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	GGCAAGGGCACGGTAAGAGGC	0.532			T	TRB@	T-ALL								15	45					0	0	0	0	T	32740034	T	T	32740034	3	4	151	1	0	0	0	0	1	0	0	0	8716	550	19	1	106	1	LCK	1	32740034	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	6076192	32740034	216510587	2	27448											
TMEM54	113452	broad.mit.edu	37	chr1	33363922	33363922	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcccacactcaggcctccTgtgggggacagctatgtcag	7	8	12	14	1	2	0	2	0	0	0	4	1	3	1	3	3	1	1	3	3	1	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:33363922T>A	uc001bwi.1	-	2	131	c.17_splice	c.e2-1	p.G6_splice	TMEM54_uc001bwj.1_Splice_Site_p.G6_splice|TMEM54_uc001bwk.1_Splice_Site_p.G6_splice	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54							integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TCAGGCCTCCTGTGGGGGACA	0.602													15	37					0	0	0	0	A	33363922	A	A	33363922	5	1	151	1	0	0	0	0	0	0	1	0	16246	1594	55	5	673	5	TMEM54	1	33363922	Splice_Site	SNP	T	TCGA-CR-7383-01A-11D-2129-08	623888	33363922	215886699	3	27449											
PTCH2	8643	broad.mit.edu	37	chr1	45293182	45293182	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgcagatcaaagagggCgcgttgggagtgggcgtagt	8	8	19	6	3	1	2	1	0	0	2	1	3	1	3	0	4	1	3	0	4	2	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:45293182C>T	uc010olf.1	-	15	2275	c.2263G>A	c.(2263-2265)GCC>ACC	p.A755T	PTCH2_uc010olg.1_Missense_Mutation_p.A453T	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	755	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					TCAAAGAGGGCGCGTTGGGAG	0.642									Basal_Cell_Nevus_syndrome				12	29					0	0	0	0	T	45293182	T	T	45293182	3	4	151	1	0	0	0	0	1	0	0	0	12793	768	27	1	1400	1	PTCH2	1	45293182	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	11929260	45293182	203957439	4	27450											
TACSTD2	4070	broad.mit.edu	37	chr1	59042502	59042502	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccttgaagcggccctcgggGtcgcagtcggggtcgtagag	5	7	18	11	5	0	2	0	1	0	1	4	2	0	2	2	5	1	2	2	5	2	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:59042502G>A	uc001cyz.3	-	1	665	c.327C>T	c.(325-327)GAC>GAT	p.D109D		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	109	Extracellular (Potential).|Thyroglobulin type-1.				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					GGCCCTCGGGGTCGCAGTCGG	0.701													4	11					0	0	0	0	A	59042502	A	A	59042502	2	1	151	1	0	0	0	0	0	0	0	1	15574	1252	44	4		4	TACSTD2	1	59042502	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08	13749320	59042502	190208119	5	27451											
PKN2	5586	broad.mit.edu	37	chr1	89298809	89298809	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggggctagcgagaaagatgCagaggatgtaaaaaagcacc	16	5	14	6	1	0	3	0	0	0	3	0	5	0	4	1	3	3	4	1	3	5	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:89298809C>T	uc001dmn.2	+	21	3062	c.2720C>T	c.(2719-2721)GCA>GTA	p.A907V	PKN2_uc010osp.1_Missense_Mutation_p.A891V|PKN2_uc010osq.1_Missense_Mutation_p.A750V|PKN2_uc009wcv.2_Missense_Mutation_p.A859V|PKN2_uc010osr.1_Missense_Mutation_p.A572V	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	907	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		GAGAAAGATGCAGAGGATGTA	0.318													3	24					0	0	0	0	T	89298809	T	T	89298809	3	4	151	1	0	0	0	0	1	0	0	0	12035	710	25	4	2802	4	PKN2	1	89298809	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	30256307	89298809	159951812	6	27452											
ABCA4	24	broad.mit.edu	37	chr1	94506793	94506793	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttcctttggctctggatgTttttcatcttgcgcaccaag	5	17	8	11	1	3	0	1	0	2	0	4	1	4	1	2	2	1	3	2	2	1	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:94506793T>C	uc001dqh.2	-	23	3598	c.3494A>G	c.(3493-3495)AAC>AGC	p.N1165S		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1165	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GCTCTGGATGTTTTTCATCTT	0.562													10	53					0	0	0	0	C	94506793	C	C	94506793	3	2	151	1	0	0	0	0	1	0	0	0	34	1725	60	5	3439	5	ABCA4	1	94506793	Missense_Mutation	SNP	T	TCGA-CR-7383-01A-11D-2129-08	5207984	94506793	154743828	7	27453											
PTPN22	26191	broad.mit.edu	37	chr1	114397603	114397603	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagatgagctcaagaataggGtctatagatgaaggtacatc	15	9	11	6	0	2	5	1	2	1	3	3	5	2	5	0	2	2	2	0	2	7	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:114397603G>A	uc001eds.2	-	8	739	c.609C>T	c.(607-609)GAC>GAT	p.D203D	uc001edv.1_5'Flank|PTPN22_uc009wgq.2_Silent_p.D203D|PTPN22_uc010owo.1_Intron|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Silent_p.D203D|PTPN22_uc009wgs.2_Intron|PTPN22_uc001edu.2_Silent_p.D203D	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	203	Tyrosine-protein phosphatase.				negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAGAATAGGGTCTATAGATG	0.368													29	83					0	0	0	0	A	114397603	A	A	114397603	2	1	151	1	0	0	0	0	0	0	0	1	12852	1252	44	4		4	PTPN22	1	114397603	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08	19890810	114397603	134853018	8	27454											
NOTCH2	4853	broad.mit.edu	37	chr1	120458389	120458389	+	Frame_Shift_Del	DEL	G	-	-																															actgaggctggggagcccccGctggttgggcaatactgcct																										TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:120458389delG	uc001eik.2	-	34	7212	c.6956delC	c.(6955-6957)GCGfs	p.A2319fs		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	2319	Cytoplasmic (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGAGCCCCCGCTGGTTGGGC	0.622			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				---	---	---								-	120458389	-	-	120458389	7	5	151	1	0	1	0	1	0	0	0	0	10602	1087	38	0	463	0	NOTCH2	1	120458389	Frame_Shift_Del	DEL	G	TCGA-CR-7383-01A-11D-2129-08	6060786	120458389	128792232	9	27455											
PAPPA2	60676	broad.mit.edu	37	chr1	176738746	176738746	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aatttctctgtttctagaagGaaattctgctcacatgttct	10	17	6	8	0	5	1	1	0	4	1	6	2	5	2	0	1	1	3	0	1	4	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:176738746G>T	uc001gkz.2	+	16	5491	c.4327G>T	c.(4327-4329)GAA>TAA	p.E1443*	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1443	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTTCTAGAAGGAAATTCTGCT	0.453													11	54					1.08611e-07	1.19694e-07	1	0	T	176738746	T	T	176738746	4	4	151	1	0	0	0	0	0	1	0	0	11487	1175	41	2	4438	2	PAPPA2	1	176738746	Nonsense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	56280357	176738746	72511875	10	27456											
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200818427	200818427	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	taaaagagagcatggagaatCctcaagccaaatggctaaag	18	6	10	7	0	1	2	1	0	0	2	2	4	2	2	2	2	2	2	2	2	7	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:200818427C>T	uc001gvl.2	+	12	2833	c.2563C>T	c.(2563-2565)CCT>TCT	p.P855S	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.P844S|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.P828S	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	855						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CATGGAGAATCCTCAAGCCAA	0.413													13	95					0	0	0	0	T	200818427	T	T	200818427	3	4	151	1	0	0	0	0	1	0	0	0	2624	855	30	2	2572	2	CAMSAP1L1	1	200818427	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	24079681	200818427	48432194	11	27457											
IPO9	55705	broad.mit.edu	37	chr1	201817629	201817629	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccattgcccactgggactggCctgaagcttggccccaactc	7	8	10	16	0	0	1	0	1	0	0	1	2	0	2	5	3	3	1	5	3	2	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:201817629C>A	uc001gwz.2	+	4	471	c.421C>A	c.(421-423)CCT>ACT	p.P141T		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	141					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						CTGGGACTGGCCTGAAGCTTG	0.542													10	46					1.58986e-06	1.72858e-06	1	0	A	201817629	A	A	201817629	3	1	151	1	0	0	0	0	1	0	0	0	7838	739	26	4	435	4	IPO9	1	201817629	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	999202	201817629	47432992	12	27458											
GNPAT	8443	broad.mit.edu	37	chr1	231396328	231396330	+	In_Frame_Del	DEL	AAA	-	-																															tcttagatgaaatgagtcacAaactgcgtcttggagccatt																										TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:231396328_231396330delAAA	uc001hup.3	+	3	543_545	c.337_339delAAA	c.(337-339)AAAdel	p.K113del	GNPAT_uc009xfo.1_In_Frame_Del_p.K4del|GNPAT_uc009xfp.2_In_Frame_Del_p.K52del	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	113					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				AATGAGTCACAAACTGCGTCTTG	0.414													---	---	---								-	231396330	-	-	231396328	7	5	151	1	0	1	0	1	0	0	0	0	6578	131	5	0	347	0	GNPAT	1	231396328	In_Frame_Del	DEL	AAA	TCGA-CR-7383-01A-11D-2129-08	29578699	231396328	17854293	13	27459											
DISC1	27185	broad.mit.edu	37	chr1	231829916	231829916	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcttagctggccgtgtggcCctgggagtgctgggtggcag	3	9	20	9	1	0	0	0	0	0	0	0	1	0	1	2	6	2	4	2	6	1	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:231829916C>A	uc001huz.2	+	2	465	c.412C>A	c.(412-414)CCT>ACT	p.P138T	TSNAX-DISC1_uc010pwe.1_Missense_Mutation_p.P93T|TSNAX-DISC1_uc010pwf.1_Missense_Mutation_p.P93T|TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.P127T|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.P93T|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.P93T|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.P127T|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.P127T|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwo.1_Missense_Mutation_p.P138T|DISC1_uc010pwp.1_Missense_Mutation_p.P138T|DISC1_uc010pwq.1_Missense_Mutation_p.P138T|DISC1_uc010pwr.1_Missense_Mutation_p.P138T|DISC1_uc010pws.1_Missense_Mutation_p.P138T|DISC1_uc010pwt.1_Missense_Mutation_p.P138T|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.P138T|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.P138T|DISC1_uc010pxb.1_Missense_Mutation_p.P138T|DISC1_uc010pxc.1_Missense_Mutation_p.P138T|DISC1_uc010pxd.1_5'UTR|DISC1_uc010pxe.1_Missense_Mutation_p.P138T|DISC1_uc009xfr.2_Missense_Mutation_p.P93T|DISC1_uc010pxf.1_Missense_Mutation_p.P138T|DISC1_uc010pxg.1_Missense_Mutation_p.P138T|DISC1_uc010pxh.1_Missense_Mutation_p.P138T|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_5'UTR|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.P138T|DISC1_uc010pxn.1_5'UTR|DISC1_uc001hva.2_Missense_Mutation_p.P138T|DISC1_uc010pwm.1_Missense_Mutation_p.P138T|DISC1_uc001hux.1_Missense_Mutation_p.P138T|DISC1_uc001hvc.3_Missense_Mutation_p.P138T|DISC1_uc010pwn.1_Missense_Mutation_p.P138T	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	138	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				GCCGTGTGGCCCTGGGAGTGC	0.612													8	23					0.00448238	0.00465478	1	0	A	231829916	A	A	231829916	3	1	151	1	0	0	0	0	1	0	0	0	4560	623	22	4	418	4	DISC1	1	231829916	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	433588	231829916	17420705	14	27460											
RBM34	23029	broad.mit.edu	37	chr1	235324629	235324629	+	5'Flank	DEL	C	-	-																															gctctctggccacgccccctCccctccggcagtcggccgcc																										TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:235324629delC	uc001hwn.2	-						RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_5'Flank	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1							nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			CACGCCCCCTCCCCTCCGGCA	0.677													---	---	---								-	235324629	-	-	235324629	6	5	151	0	1	1	0	1	0	0	0	0	13196	870	30	0		0	RBM34	1	235324629	5'Flank	DEL	C	TCGA-CR-7383-01A-11D-2129-08	3494713	235324629	13925992	15	27461											
ZNF670	93474	broad.mit.edu	37	chr1	247201495	247201495	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctttcccacattgtttgcaAtgatataacttctctggaca	10	15	6	10	0	1	1	0	1	1	0	3	2	2	2	1	1	2	3	1	1	3	6			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:247201495A>G	uc001icd.1	-	4	597	c.426T>C	c.(424-426)CAT>CAC	p.H142H	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	142	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			ATTGTTTGCAATGATATAACT	0.413													41	140					0	0	0	0	G	247201495	G	G	247201495	2	3	151	1	0	0	0	0	0	0	0	1	18144	98	4	5		5	ZNF670	1	247201495	Silent	SNP	A	TCGA-CR-7383-01A-11D-2129-08	11876866	247201495	2049126	16	27462											
OR2T12	127064	broad.mit.edu	37	chr1	248458349	248458349	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgcaccaacacgggggcctCgcagaagaagtgatcgatct	12	5	12	12	4	1	3	0	1	1	2	3	4	1	3	2	2	1	2	2	2	3	0			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:248458349C>T	uc010pzj.1	-	1	532	c.532G>A	c.(532-534)GAG>AAG	p.E178K		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ACGGGGGCCTCGCAGAAGAAG	0.567													26	72					0	0	0	0	T	248458349	T	T	248458349	3	4	151	1	0	0	0	0	1	0	0	0	11073	893	31	1	433	1	OR2T12	1	248458349	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	1256854	248458349	792272	17	27463											
OR2T4	127074	broad.mit.edu	37	chr1	248524920	248524920	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggccagccacactggatGgtcggatttcatcctgatgg	8	10	13	10	1	1	1	1	1	0	0	3	4	2	3	3	5	1	0	3	5	0	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:248524920G>T	uc001ieh.1	+	1	38	c.38G>T	c.(37-39)TGG>TTG	p.W13L		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CACACTGGATGGTCGGATTTC	0.483													11	47					0.000151284	0.000163387	1	0	T	248524920	T	T	248524920	3	4	151	1	0	0	0	0	1	0	0	0	11081	1357	47	4	40	4	OR2T4	1	248524920	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	66571	248524920	725701	18	27464											
OR2G6	391211	broad.mit.edu	37	chr1	248685642	248685642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttaaggataaaatcagctgCgggccgccaaaaggcctttg	12	8	12	9	2	1	0	1	0	0	0	1	1	1	1	3	3	2	2	3	3	5	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr1:248685642C>T	uc001ien.1	+	1	695	c.695C>T	c.(694-696)GCG>GTG	p.A232V		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAATCAGCTGCGGGCCGCCAA	0.468													27	70					0	0	0	0	T	248685642	T	T	248685642	3	4	151	1	0	0	0	0	1	0	0	0	11054	768	27	1	697	1	OR2G6	1	248685642	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	160722	248685642	564979	19	27465											
NBAS	51594	broad.mit.edu	37	chr2	15415841	15415841	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atccttttcagggattttggGaacaagtttggaaatagaca	13	13	10	5	0	1	1	1	0	0	1	2	4	2	4	1	3	1	1	1	3	4	6			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:15415841G>A	uc002rcc.1	-	44	5517	c.5491C>T	c.(5491-5493)CCC>TCC	p.P1831S	NBAS_uc010exl.1_Missense_Mutation_p.P903S|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1831										ovary(2)|liver(1)|skin(1)	4						GGGATTTTGGGAACAAGTTTG	0.403													9	58					0	0	0	0	A	15415841	A	A	15415841	3	1	151	1	0	0	0	0	1	0	0	0	10239	1174	41	2	1660	2	NBAS	2	15415841	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08		15415841	227783532	20	27466											
RAD51AP2	729475	broad.mit.edu	37	chr2	17697544	17697544	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattcacaacttgttgaggAcaactcatattctgacaagt	14	12	6	9	0	3	2	2	2	1	0	3	3	3	3	0	1	2	1	0	1	4	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:17697544A>G	uc002rcl.1	-	1	2163	c.2139T>C	c.(2137-2139)TGT>TGC	p.C713C	RAD51AP2_uc010exn.1_Silent_p.C704C	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	713										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTTGTTGAGGACAACTCATAT	0.323													6	66					0	0	0	0	G	17697544	G	G	17697544	2	3	151	1	0	0	0	0	0	0	0	1	13052	273	10	5		5	RAD51AP2	2	17697544	Silent	SNP	A	TCGA-CR-7383-01A-11D-2129-08	2281703	17697544	225501829	21	27467											
LYG2	254773	broad.mit.edu	37	chr2	99863255	99863255	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgaggcttcattgagtgActgaaggggtatgagcccct	9	10	15	7	0	1	5	1	5	0	0	1	5	1	5	2	4	1	2	2	4	2	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:99863255A>C	uc002szw.1	-	3	185	c.72T>G	c.(70-72)AGT>AGG	p.S24R	MRPL30_uc002szl.1_Intron|LYG2_uc010fip.1_Missense_Mutation_p.S24R|LYG2_uc002szx.1_Missense_Mutation_p.S24R	NM_175735	NP_783862	Q86SG7	LYG2_HUMAN	lysozyme G-like 2 precursor	24					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			ovary(1)	1						TCATTGAGTGACTGAAGGGGT	0.502													21	74					0	0	0	0	C	99863255	C	C	99863255	3	2	151	1	0	0	0	0	1	0	0	0	9156	272	10	5	582	5	LYG2	2	99863255	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	82165711	99863255	143336118	22	27468											
EIF5B	9669	broad.mit.edu	37	chr2	100011184	100011184	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtgttttaaccttttaggtAtgcagtaattttggccttcg	7	19	9	6	1	0	0	0	0	0	0	1	0	0	0	2	2	2	4	2	2	4	9			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:100011184A>G	uc002tab.2	+	21	3276	c.3092A>G	c.(3091-3093)TAT>TGT	p.Y1031C	EIF5B_uc010yvq.1_Missense_Mutation_p.Y13C	NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	1031					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						CCTTTTAGGTATGCAGTAATT	0.338													24	102					0	0	0	0	G	100011184	G	G	100011184	3	3	151	1	0	0	0	0	1	0	0	0	5068	449	16	5	3174	5	EIF5B	2	100011184	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	147929	100011184	143188189	23	27469											
NFE2L2	4780	broad.mit.edu	37	chr2	178098945	178098945	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	actgaagtcaaatacttctcGacttactccaagatctatat	14	13	4	10	1	3	2	1	1	2	1	5	3	4	2	1	0	2	0	1	0	7	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:178098945G>C	uc002ulh.3	-	2	655	c.100C>G	c.(100-102)CGA>GGA	p.R34G	NFE2L2_uc002ulg.3_Missense_Mutation_p.R18G|NFE2L2_uc010zfa.1_Missense_Mutation_p.R18G|NFE2L2_uc002uli.3_Missense_Mutation_p.R18G|NFE2L2_uc010fra.2_Missense_Mutation_p.R18G|NFE2L2_uc010frb.2_Missense_Mutation_p.R18G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	34					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AATACTTCTCGACTTACTCCA	0.368			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			20	41					0	0	0	0	C	178098945	C	C	178098945	3	2	151	1	0	0	0	0	1	0	0	0	10422	1066	37	3	1733	3	NFE2L2	2	178098945	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	78087761	178098945	65100428	24	27470											
TTN	7273	broad.mit.edu	37	chr2	179395925	179395925	+	Frame_Shift_Del	DEL	G	-	-																															gcagactcgccctcgtagacGgtcatggaccgtggctttgt																										TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr2:179395925delG	uc010zfg.1	-	307	97937	c.97713delC	c.(97711-97713)ACCfs	p.T32571fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Del_p.T26266fs|TTN_uc010zfi.1_Frame_Shift_Del_p.T26199fs|TTN_uc010zfj.1_Frame_Shift_Del_p.T26074fs|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33498							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCGTAGACGGTCATGGACC	0.483													---	---	---								-	179395925	-	-	179395925	7	5	151	1	0	1	0	1	0	0	0	0	16803	1103	39	0	2582	0	TTN	2	179395925	Frame_Shift_Del	DEL	G	TCGA-CR-7383-01A-11D-2129-08	1296980	179395925	63803448	25	27471											
HHATL	57467	broad.mit.edu	37	chr3	42739102	42739102	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacggccatgatggccaccaCgcttaggcctgcctgggctc	6	7	13	15	2	0	1	0	1	0	0	1	2	0	1	5	4	1	2	5	4	1	1	rs140686107		TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr3:42739102C>T	uc003clw.2	-	8	910	c.763G>A	c.(763-765)GTG>ATG	p.V255M	HHATL_uc003clx.2_Missense_Mutation_p.V255M	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	255	Helical; (Potential).				negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		ATGGCCACCACGCTTAGGCCT	0.612													9	69					0	0	0	0	T	42739102	T	T	42739102	3	4	151	1	0	0	0	0	1	0	0	0	7129	536	19	1	775	1	HHATL	3	42739102	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08		42739102	155283328	26	27472											
ZIC4	84107	broad.mit.edu	37	chr3	147114119	147114119	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccggccgcgcgtacatgtCtccagggagccccagacgca	7	5	12	17	5	1	1	0	0	1	1	3	2	2	2	5	2	2	2	5	2	1	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr3:147114119C>G	uc003ewd.1	-	3	481	c.208G>C	c.(208-210)GAC>CAC	p.D70H	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Missense_Mutation_p.D120H	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	70						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GCGTACATGTCTCCAGGGAGC	0.726													7	11					0	0	0	0	G	147114119	G	G	147114119	3	3	151	1	0	0	0	0	1	0	0	0	17748	913	32	2	808	2	ZIC4	3	147114119	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	104375017	147114119	50908311	27	27473											
SKIL	6498	broad.mit.edu	37	chr3	170078020	170078020	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaagtttgagagtaagttaCgataggcatttgtatccatt	13	14	10	4	1	0	1	0	1	0	1	1	4	1	1	1	1	1	5	1	1	5	7			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr3:170078020C>T	uc003fgu.2	+	2	613	c.-99C>T	c.(-101--97)TACGA>TATGA		SKIL_uc011bps.1_Intron|SKIL_uc003fgv.2_Translation_Start_Site|SKIL_uc003fgw.2_Translation_Start_Site	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1						cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GAGTAAGTTACGATAGGCATT	0.308													8	28					0	0	0	0	T	170078020	T	T	170078020	1	4	151	1	0	0	0	0	0	0	0	0	14423	551	19	1		1	SKIL	3	170078020	Translation_Start_Site	SNP	C	TCGA-CR-7383-01A-11D-2129-08	22963901	170078020	27944410	28	27474											
KLHL24	54800	broad.mit.edu	37	chr3	183381264	183381264	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggtccactggctattctgaGgtgatagttgtcgttggagg	7	13	15	6	1	1	2	0	2	1	0	3	3	2	3	1	5	0	3	1	5	2	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr3:183381264G>A	uc003flv.2	+	4	1234	c.939G>A	c.(937-939)GAG>GAA	p.E313E	KLHL24_uc003flw.2_Silent_p.E313E|KLHL24_uc003flx.2_Silent_p.E313E	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	313						axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GCTATTCTGAGGTGATAGTTG	0.333													32	83					0	0	0	0	A	183381264	A	A	183381264	2	1	151	1	0	0	0	0	0	0	0	1	8418	991	35	4		4	KLHL24	3	183381264	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08	13303244	183381264	14641166	29	27475											
TNK2	10188	broad.mit.edu	37	chr3	195595233	195595233	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtcgtcataggcgggcggggGgggcagcgggcgtgcgtccc	3	5	22	11	6	1	0	1	0	0	0	3	0	2	0	1	7	2	1	1	7	1	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr3:195595233G>C	uc003fvu.1	-	12	2434	c.1891C>G	c.(1891-1893)CCC>GCC	p.P631A	TNK2_uc003fvq.1_Missense_Mutation_p.P38A|TNK2_uc003fvr.1_Missense_Mutation_p.P156A|TNK2_uc003fvs.1_Missense_Mutation_p.P663A|TNK2_uc003fvt.1_Missense_Mutation_p.P709A|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_3'UTR	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	631	Required for interaction with SRC.|Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GCGGGCGGGGGGGGCAGCGGG	0.726													7	33					0	0	0	0	C	195595233	C	C	195595233	3	2	151	1	0	0	0	0	1	0	0	0	16384	1232	43	4	1241	4	TNK2	3	195595233	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	12213969	195595233	2427197	30	27476											
SH3TC1	54436	broad.mit.edu	37	chr4	8224685	8224685	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcaccgatgtctgcagcGtgtacagcctgggtgcgtgt	5	9	16	11	4	1	0	0	0	1	0	1	1	1	0	2	2	5	3	2	2	1	1	rs148540586		TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr4:8224685G>T	uc003gkv.3	+	10	1332	c.1231G>T	c.(1231-1233)GTG>TTG	p.V411L	SH3TC1_uc003gkw.3_Missense_Mutation_p.V335L|SH3TC1_uc003gkx.3_RNA	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	411							binding			large_intestine(2)|pancreas(1)	3						TGTCTGCAGCGTGTACAGCCT	0.602													6	21					0.00198382	0.00210051	1	0	T	8224685	T	T	8224685	3	4	151	1	0	0	0	0	1	0	0	0	14326	1145	40	3	1265	3	SH3TC1	4	8224685	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08		8224685	182929591	31	27477											
NPFFR2	10886	broad.mit.edu	37	chr4	73012967	73012967	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacctggctcccctctcccTcattgtcatcatgtatggaa	7	13	6	15	0	4	0	3	0	1	0	6	1	5	1	4	2	1	2	4	2	3	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr4:73012967T>A	uc003hgg.2	+	4	1105	c.1007T>A	c.(1006-1008)CTC>CAC	p.L336H	NPFFR2_uc010iig.1_Missense_Mutation_p.L118H|NPFFR2_uc003hgi.2_Missense_Mutation_p.L237H|NPFFR2_uc003hgh.2_Missense_Mutation_p.L234H|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	336	Helical; Name=5; (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			CCCCTCTCCCTCATTGTCATC	0.527													16	36					0	0	0	0	A	73012967	A	A	73012967	3	1	151	1	0	0	0	0	1	0	0	0	10632	1551	54	5	1027	5	NPFFR2	4	73012967	Missense_Mutation	SNP	T	TCGA-CR-7383-01A-11D-2129-08	64788282	73012967	118141309	32	27478											
HPSE	10855	broad.mit.edu	37	chr4	84216583	84216583	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtgaacttcctggccggaGaggtttttccattaaaggtg	9	12	12	8	1	0	2	0	1	0	1	2	3	2	2	3	4	1	1	3	4	3	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr4:84216583G>C	uc003hoj.3	-	12	1645	c.1546C>G	c.(1546-1548)CTC>GTC	p.L516V	uc003hoi.2_5'Flank|HPSE_uc010ika.2_Missense_Mutation_p.L458V|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.L259V|HPSE_uc011cct.1_Missense_Mutation_p.L442V|HPSE_uc003hok.3_Missense_Mutation_p.L516V	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	516					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	CCTGGCCGGAGAGGTTTTTCC	0.403													11	69					0	0	0	0	C	84216583	C	C	84216583	3	2	151	1	0	0	0	0	1	0	0	0	7383	942	33	2	89	2	HPSE	4	84216583	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	11203616	84216583	106937693	33	27479											
FSTL5	56884	broad.mit.edu	37	chr4	162463813	162463813	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccccaggctctctagcctGactctctggatacacccgga	8	9	8	16	1	2	1	0	1	2	0	4	3	2	3	4	3	3	1	4	3	3	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr4:162463813G>T	uc003iqh.2	-	9	1484	c.1048C>A	c.(1048-1050)CAG>AAG	p.Q350K	FSTL5_uc003iqi.2_Missense_Mutation_p.Q349K|FSTL5_uc010iqv.2_Missense_Mutation_p.Q349K	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	350	Ig-like 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TCTCTAGCCTGACTCTCTGGA	0.418													10	58					9.05144e-12	1.02541e-11	1	0	T	162463813	T	T	162463813	3	4	151	1	0	0	0	0	1	0	0	0	6114	1299	45	2	1527	2	FSTL5	4	162463813	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	78247230	162463813	28690463	34	27480											
MYO10	4651	broad.mit.edu	37	chr5	16674967	16674967	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccccatgctttaccttttCagatggaacttgagatactt	9	14	7	11	0	1	2	1	1	0	2	1	4	1	3	3	1	4	1	3	1	3	7			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr5:16674967C>T	uc003jft.3	-	35	5427	c.4959G>A	c.(4957-4959)CTG>CTA	p.L1653L	MYO10_uc011cnb.1_Silent_p.L282L|MYO10_uc011cnc.1_Silent_p.L532L|MYO10_uc011cnd.1_Silent_p.L1010L|MYO10_uc011cne.1_Silent_p.L1010L|MYO10_uc010itx.2_Silent_p.L1275L	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1653	MyTH4.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TTTACCTTTTCAGATGGAACT	0.547													15	135					0	0	0	0	T	16674967	T	T	16674967	2	4	151	1	0	0	0	0	0	0	0	1	10115	813	29	2		2	MYO10	5	16674967	Silent	SNP	C	TCGA-CR-7383-01A-11D-2129-08		16674967	164240293	35	27481											
PCDHA12	56137	broad.mit.edu	37	chr5	140255327	140255327	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtttgtgaattctcggatCgaccgcgagaagctgtgcgg	7	12	14	8	5	1	2	0	1	1	1	3	5	1	3	1	2	2	2	1	2	2	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr5:140255327C>A	uc003lic.2	+	1	397	c.270C>A	c.(268-270)ATC>ATA	p.I90I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.I90I	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	90	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATCGACCGCGAGA	0.597													29	226					4.74835e-14	5.49452e-14	1	0	A	140255327	A	A	140255327	2	1	151	1	0	0	0	0	0	0	0	1	11576	874	31	3		3	PCDHA12	5	140255327	Silent	SNP	C	TCGA-CR-7383-01A-11D-2129-08	123580360	140255327	40659933	36	27482											
FAT2	2196	broad.mit.edu	37	chr5	150922100	150922100	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctggcaggtctcacagtcaAgttcctggagtgtggtgatc	7	12	13	9	0	3	1	2	1	2	0	6	2	4	2	1	4	0	2	1	4	1	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr5:150922100A>G	uc003lue.3	-	9	8601	c.8588T>C	c.(8587-8589)CTT>CCT	p.L2863P	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2863	Extracellular (Potential).|Cadherin 25.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCACAGTCAAGTTCCTGGAG	0.532													10	79					0	0	0	0	G	150922100	G	G	150922100	3	3	151	1	0	0	0	0	1	0	0	0	5722	72	3	5	4521	5	FAT2	5	150922100	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	10666773	150922100	29993160	37	27483											
LARP1	23367	broad.mit.edu	37	chr5	154183811	154183811	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcaaacccacccttggagagCcatgtgggctgggtgatgga	9	8	14	10	0	1	2	1	1	0	1	1	4	1	3	3	4	2	1	3	4	1	1	rs140378046	byFrequency	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr5:154183811C>T	uc003lvp.2	+	14	2919	c.2490C>T	c.(2488-2490)AGC>AGT	p.S830S	LARP1_uc003lvo.2_Silent_p.S753S	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	830							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CCTTGGAGAGCCATGTGGGCT	0.537													6	128					0	0	0	0	T	154183811	T	T	154183811	2	4	151	1	0	0	0	0	0	0	0	1	8668	738	26	4		4	LARP1	5	154183811	Silent	SNP	C	TCGA-CR-7383-01A-11D-2129-08	3261711	154183811	26731449	38	27484											
CNOT8	9337	broad.mit.edu	37	chr5	154250226	154250226	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccttgttttttagagaggAcatgtactcccaggattcca	10	13	8	10	0	0	1	0	0	0	1	2	4	2	3	3	2	1	2	3	2	2	6			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr5:154250226A>G	uc003lvu.2	+	5	796	c.317A>G	c.(316-318)GAC>GGC	p.D106G	CNOT8_uc011ddf.1_5'UTR|CNOT8_uc011ddg.1_5'UTR|CNOT8_uc011ddh.1_Intron|CNOT8_uc003lvv.2_Missense_Mutation_p.D106G|CNOT8_uc010jig.2_5'UTR|CNOT8_uc010jif.2_5'UTR|CNOT8_uc003lvw.2_Missense_Mutation_p.D106G|CNOT8_uc011ddi.1_5'UTR|CNOT8_uc011ddj.1_Intron	NM_004779	NP_004770	Q9UFF9	CNOT8_HUMAN	CCR4-NOT transcription complex, subunit 8	106					negative regulation of cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTTAGAGAGGACATGTACTCC	0.393								Direct_reversal_of_damage					22	80					0	0	0	0	G	154250226	G	G	154250226	3	3	151	1	0	0	0	0	1	0	0	0	3640	275	10	5	327	5	CNOT8	5	154250226	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	66415	154250226	26665034	39	27485											
ACOT13	55856	broad.mit.edu	37	chr6	24667534	24667534	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgggaggtgataaaggccAtgaccaaggctcgcaatttt	11	9	13	8	2	0	2	0	2	0	0	1	3	0	3	2	4	1	2	2	4	4	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:24667534A>G	uc003nek.2	+	1	272	c.43A>G	c.(43-45)ATG>GTG	p.M15V	TDP2_uc003nei.2_5'Flank|TDP2_uc003nej.2_5'Flank|TDP2_uc010jpu.1_5'Flank|ACOT13_uc010jpv.2_5'UTR	NM_018473	NP_060943	Q9NPJ3	ACO13_HUMAN	acyl-CoA thioesterase 13 isoform 1	15					protein homotetramerization	mitochondrion	acyl-CoA thioesterase activity				0						GATAAAGGCCATGACCAAGGC	0.512											OREG0017230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	23					0	0	0	0	G	24667534	G	G	24667534	3	3	151	1	0	0	0	0	1	0	0	0	151	217	8	5	45	5	ACOT13	6	24667534	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08		24667534	146447533	40	27486											
RUNX2	860	broad.mit.edu	37	chr6	45459775	45459775	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccagtatgagagtaggtgtCccgcctcagaacccacggcc	9	6	11	15	2	1	2	1	1	0	2	2	3	2	2	5	2	1	2	5	2	3	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:45459775C>A	uc011dvx.1	+	6	993	c.783C>A	c.(781-783)GTC>GTA	p.V261V	RUNX2_uc011dvy.1_Silent_p.V261V|RUNX2_uc003oxt.2_Silent_p.V247V	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	261	Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						GAGTAGGTGTCCCGCCTCAGA	0.502													14	128					1.05317e-09	1.17665e-09	1	0	A	45459775	A	A	45459775	2	1	151	1	0	0	0	0	0	0	0	1	13813	842	30	2		2	RUNX2	6	45459775	Silent	SNP	C	TCGA-CR-7383-01A-11D-2129-08	20792241	45459775	125655292	41	27487											
KHDRBS2	202559	broad.mit.edu	37	chr6	62390900	62390900	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ataggggtgttccctgtatcCccctctggctgacctttgcg	4	13	11	13	1	1	1	0	1	1	0	3	1	3	1	4	3	1	3	4	3	2	4	rs139583671		TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:62390900C>G	uc003peg.2	-	9	1265	c.1018G>C	c.(1018-1020)GGA>CGA	p.G340R		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TCCCTGTATCCCCCTCTGGCT	0.493													13	45					0	0	0	0	G	62390900	G	G	62390900	3	3	151	1	0	0	0	0	1	0	0	0	8186	632	22	4	35	4	KHDRBS2	6	62390900	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	16931125	62390900	108724167	42	27488											
GPRC6A	222545	broad.mit.edu	37	chr6	117128089	117128089	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgattttcttcagtgtcCgattgattctgacttcaatg	10	17	7	7	1	4	3	2	3	2	0	5	4	5	3	1	0	0	0	1	0	2	6			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:117128089C>T	uc003pxj.1	-	3	801	c.779G>A	c.(778-780)CGG>CAG	p.R260Q	GPRC6A_uc003pxk.1_Missense_Mutation_p.R260Q|GPRC6A_uc003pxl.1_Missense_Mutation_p.R260Q	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	260	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CTTCAGTGTCCGATTGATTCT	0.363													11	77					0	0	0	0	T	117128089	T	T	117128089	3	4	151	1	0	0	0	0	1	0	0	0	6767	652	23	1	2017	1	GPRC6A	6	117128089	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	54737189	117128089	53986978	43	27489											
SMPDL3A	10924	broad.mit.edu	37	chr6	123130244	123130244	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcttaactgcaggatatgttGcagtattacttgaatctgac	11	15	8	7	0	2	2	0	2	2	0	2	3	2	3	0	1	4	4	0	1	5	6			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:123130244G>T	uc003pzg.2	+	8	1574	c.1053G>T	c.(1051-1053)TTG>TTT	p.L351F	SMPDL3A_uc003pzh.2_Missense_Mutation_p.L220F	NM_006714	NP_006705	Q92484	ASM3A_HUMAN	acid sphingomyelinase-like phosphodiesterase 3A	351					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|protein binding|sphingomyelin phosphodiesterase activity				0				GBM - Glioblastoma multiforme(226;0.236)		AGGATATGTTGCAGTATTACT	0.413													15	81					8.60227e-14	9.88346e-14	1	0	T	123130244	T	T	123130244	3	4	151	1	0	0	0	0	1	0	0	0	14872	1310	46	4	1083	4	SMPDL3A	6	123130244	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	6002155	123130244	47984823	44	27490											
ECT2L	345930	broad.mit.edu	37	chr6	139206872	139206872	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aataccttaatcttctctacGctgtcaggcttcatacccct	9	14	4	14	1	4	0	2	0	2	0	5	0	4	0	3	1	3	2	3	1	5	6	rs79865247	byFrequency	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:139206872G>A	uc003qif.1	+	16	2267	c.2164G>A	c.(2164-2166)GCT>ACT	p.A722T	ECT2L_uc011edq.1_Intron	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	722	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TCTTCTCTACGCTGTCAGGCT	0.468													17	40					0	0	0	0	A	139206872	A	A	139206872	3	1	151	1	0	0	0	0	1	0	0	0	4924	1087	38	1	2226	1	ECT2L	6	139206872	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	16076628	139206872	31908195	45	27491											
MYCT1	80177	broad.mit.edu	37	chr6	153043080	153043080	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccacagtggctgtgaacgtCgaagcaacctcagcctggcc	9	6	12	14	2	1	1	1	1	0	0	2	2	1	1	4	2	4	2	4	2	3	0			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr6:153043080C>T	uc003qpd.3	+	2	408	c.400C>T	c.(400-402)CGA>TGA	p.R134*	MYCT1_uc010kjc.1_Intron|MYCT1_uc003qpc.3_Nonsense_Mutation_p.R134*	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	134						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		CTGTGAACGTCGAAGCAACCT	0.498													26	100					0	0	0	0	T	153043080	T	T	153043080	4	4	151	1	0	0	0	0	0	1	0	0	10075	876	31	1	406	1	MYCT1	6	153043080	Nonsense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	13836208	153043080	18071987	46	27492											
DDC	1644	broad.mit.edu	37	chr7	50611624	50611624	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgtcgttgatgatgtcctCaaacgtgtctggctcctgag	8	12	11	10	3	2	3	1	3	1	0	5	3	4	3	2	1	2	2	2	1	2	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr7:50611624C>A	uc003tpf.3	-	2	246	c.160G>T	c.(160-162)GAG>TAG	p.E54*	DDC_uc010kza.2_Nonsense_Mutation_p.E54*|DDC_uc003tpg.3_Nonsense_Mutation_p.E54*	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	54					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	ATGATGTCCTCAAACGTGTCT	0.562													43	94					8.01111e-26	9.40435e-26	1	0	A	50611624	A	A	50611624	4	1	151	1	0	0	0	0	0	1	0	0	4342	835	29	2	1334	2	DDC	7	50611624	Nonsense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08		50611624	108527039	47	27493											
STEAP2	261729	broad.mit.edu	37	chr7	89861767	89861767	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaccaccaaactttgttctTgctcttgttttgccctcaat	8	16	4	13	0	3	0	1	0	2	0	3	0	3	0	3	0	3	3	3	0	2	6			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr7:89861767T>G	uc003ujz.2	+	5	1695	c.1302T>G	c.(1300-1302)CTT>CTG	p.L434L	STEAP2_uc010len.2_Silent_p.L434L|STEAP2_uc003uka.2_Silent_p.L434L|STEAP2_uc003ukb.2_Silent_p.L434L|STEAP2_uc003ukc.2_Intron|STEAP2_uc003ukd.2_Silent_p.L434L	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	434	Helical; (Potential).				electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					ACTTTGTTCTTGCTCTTGTTT	0.353													14	31					0	0	0	0	G	89861767	G	G	89861767	2	3	151	1	0	0	0	0	0	0	0	1	15344	1799	63	5		5	STEAP2	7	89861767	Silent	SNP	T	TCGA-CR-7383-01A-11D-2129-08	39250143	89861767	69276896	48	27494											
SRRT	51593	broad.mit.edu	37	chr7	100479790	100479790	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacggaggccgtcaagcgctAtaatgactacaagctggatt	12	8	12	9	3	1	1	1	1	0	0	1	4	1	3	1	3	3	2	1	3	5	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr7:100479790A>G	uc003uwy.2	+	6	783	c.515A>G	c.(514-516)TAT>TGT	p.Y172C	SRRT_uc010lhl.1_Missense_Mutation_p.Y172C|SRRT_uc003uxa.2_Missense_Mutation_p.Y172C|SRRT_uc003uwz.2_Missense_Mutation_p.Y172C	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	172					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GTCAAGCGCTATAATGACTAC	0.557													12	67					0	0	0	0	G	100479790	G	G	100479790	3	3	151	1	0	0	0	0	1	0	0	0	15238	449	16	5	529	5	SRRT	7	100479790	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	10618023	100479790	58658873	49	27495											
MLL3	58508	broad.mit.edu	37	chr7	151875040	151875040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtatttgctgaggaggcaCaaggaagcgctcttgactcg	9	10	13	9	2	1	2	0	2	1	0	2	4	1	4	0	3	2	4	0	3	3	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr7:151875040C>T	uc003wla.2	-	38	7717	c.7498G>A	c.(7498-7500)GTG>ATG	p.V2500M	MLL3_uc003wkz.2_Missense_Mutation_p.V1561M|MLL3_uc003wky.2_Missense_Mutation_p.V9M	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2500	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TGAGGAGGCACAAGGAAGCGC	0.363			N		medulloblastoma								12	106					0	0	0	0	T	151875040	T	T	151875040	3	4	151	1	0	0	0	0	1	0	0	0	9675	478	17	4	7325	4	MLL3	7	151875040	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	51395250	151875040	7263623	50	27496											
HTR5A	3361	broad.mit.edu	37	chr7	154863042	154863042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgctactggtccatcacgCgccacatggaatacacgctc	10	7	8	16	4	1	0	1	0	0	0	3	1	2	1	3	2	2	2	3	2	3	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr7:154863042C>T	uc003wlu.1	+	1	497	c.433C>T	c.(433-435)CGC>TGC	p.R145C	uc011kvt.1_5'UTR|uc003wlt.2_5'UTR	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	145	Cytoplasmic (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GTCCATCACGCGCCACATGGA	0.632													7	30					0	0	0	0	T	154863042	T	T	154863042	3	4	151	1	0	0	0	0	1	0	0	0	7489	768	27	1	435	1	HTR5A	7	154863042	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	2988002	154863042	4275621	51	27497											
ST18	9705	broad.mit.edu	37	chr8	53062328	53062328	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcttcccgtgagttttgctAtagttgataggagtgtccca	7	15	11	8	1	1	2	0	2	1	0	3	3	3	3	2	1	1	3	2	1	3	7			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:53062328A>T	uc003xqz.2	-	11	2172	c.2016T>A	c.(2014-2016)TAT>TAA	p.Y672*	ST18_uc011ldq.1_Nonsense_Mutation_p.Y319*|ST18_uc011ldr.1_Nonsense_Mutation_p.Y637*|ST18_uc011lds.1_Nonsense_Mutation_p.Y577*|ST18_uc003xra.2_Nonsense_Mutation_p.Y672*|ST18_uc003xrb.2_Nonsense_Mutation_p.Y672*	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	672						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GAGTTTTGCTATAGTTGATAG	0.443													9	52					0	0	0	0	T	53062328	T	T	53062328	4	4	151	1	0	0	0	0	0	1	0	0	15278	456	16	5	1171	5	ST18	8	53062328	Nonsense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08		53062328	93301694	52	27498											
ZFHX4	79776	broad.mit.edu	37	chr8	77764890	77764890	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaggaaatgctgccaaagcGttattggaaaactttggttt	13	12	11	5	1	0	1	0	0	0	1	0	3	0	3	1	3	4	3	1	3	5	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:77764890G>A	uc003yav.2	+	10	5985	c.5598G>A	c.(5596-5598)GCG>GCA	p.A1866A	ZFHX4_uc003yau.1_Silent_p.A1911A|ZFHX4_uc003yaw.1_Silent_p.A1866A	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1866						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTGCCAAAGCGTTATTGGAAA	0.453										HNSCC(33;0.089)			4	26					0	0	0	0	A	77764890	A	A	77764890	2	1	151	1	0	0	0	0	0	0	0	1	17702	1132	40	1		1	ZFHX4	8	77764890	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08	24702562	77764890	68599132	53	27499											
SLC26A7	115111	broad.mit.edu	37	chr8	92365191	92365191	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctaatacagttccgagatttAaaaaaatattggaatgtgga	17	12	8	4	1	0	1	0	0	0	1	1	4	1	3	1	2	1	1	1	2	8	7			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:92365191A>T	uc003yex.2	+	12	1559	c.1281A>T	c.(1279-1281)TTA>TTT	p.L427F	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.L427F|SLC26A7_uc003yfa.2_Missense_Mutation_p.L427F	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	427	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TCCGAGATTTAAAAAAATATT	0.328													11	106					0	0	0	0	T	92365191	T	T	92365191	3	4	151	1	0	0	0	0	1	0	0	0	14586	359	13	5	1319	5	SLC26A7	8	92365191	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	14600301	92365191	53998831	54	27500											
VPS13B	157680	broad.mit.edu	37	chr8	100287445	100287445	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatttgatggccttcacaatCcaagttccacaatatattga	13	13	6	9	0	1	2	1	2	0	0	3	3	3	2	3	1	0	1	3	1	5	6			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:100287445C>G	uc003yiv.2	+	19	2898	c.2787C>G	c.(2785-2787)ATC>ATG	p.I929M	VPS13B_uc003yiw.2_Missense_Mutation_p.I929M|VPS13B_uc003yiu.1_Missense_Mutation_p.I929M|VPS13B_uc003yix.1_Missense_Mutation_p.I400M	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	929					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCTTCACAATCCAAGTTCCAC	0.398													13	186					0	0	0	0	G	100287445	G	G	100287445	3	3	151	1	0	0	0	0	1	0	0	0	17258	845	30	2	2980	2	VPS13B	8	100287445	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	7922254	100287445	46076577	55	27501											
SLC25A32	81034	broad.mit.edu	37	chr8	104419953	104419953	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtccatcaagtttccaaaTggtagtcaagcaatgtaaaa	16	11	7	7	0	2	0	2	0	0	0	4	0	4	0	2	1	1	4	2	1	8	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:104419953T>C	uc003yll.2	-	2	517	c.214A>G	c.(214-216)ATT>GTT	p.I72V	SLC25A32_uc011lhr.1_5'UTR	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	72	Solcar 1.				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	AGTTTCCAAATGGTAGTCAAG	0.408													18	167					0	0	0	0	C	104419953	C	C	104419953	3	2	151	1	0	0	0	0	1	0	0	0	14560	1464	51	5	757	5	SLC25A32	8	104419953	Missense_Mutation	SNP	T	TCGA-CR-7383-01A-11D-2129-08	4132508	104419953	41944069	56	27502											
LRP12	29967	broad.mit.edu	37	chr8	105509897	105509897	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagcgtaaaatgactttacGgtgatcaccagtgtctatta	13	12	9	7	2	2	2	1	2	1	0	2	3	2	2	1	1	2	1	1	1	6	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:105509897G>T	uc003yma.2	-	5	978	c.883C>A	c.(883-885)CGT>AGT	p.R295S	LRP12_uc003ymb.2_Missense_Mutation_p.R276S|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	295	Extracellular (Potential).|CUB 2.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATGACTTTACGGTGATCACCA	0.358													8	69					0.000157383	0.000168848	1	0	T	105509897	T	T	105509897	3	4	151	1	0	0	0	0	1	0	0	0	9004	1116	39	3	1708	3	LRP12	8	105509897	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	1089944	105509897	40854125	57	27503											
ADCY8	114	broad.mit.edu	37	chr8	131922053	131922053	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaaaacaccgcacagcaccGagccggagtggattccaatc	13	4	9	15	3	0	0	0	0	0	0	2	3	1	2	5	2	3	2	5	2	3	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:131922053G>A	uc003ytd.3	-	6	1797	c.1541C>T	c.(1540-1542)TCG>TTG	p.S514L	ADCY8_uc010mds.2_Missense_Mutation_p.S514L	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	514	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GCACAGCACCGAGCCGGAGTG	0.478										HNSCC(32;0.087)			12	142					0	0	0	0	A	131922053	A	A	131922053	3	1	151	1	0	0	0	0	1	0	0	0	300	1059	37	1	2266	1	ADCY8	8	131922053	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	26412156	131922053	14441969	58	27504											
PLEC	5339	broad.mit.edu	37	chr8	145001198	145001198	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgggcttcttggccggggAggccaccggctcaagctgcg	4	8	16	13	3	2	0	1	0	1	0	2	1	2	1	3	6	2	3	3	6	1	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr8:145001198A>T	uc003zaf.1	-	29	4473	c.4303T>A	c.(4303-4305)TCC>ACC	p.S1435T	PLEC_uc003zab.1_Missense_Mutation_p.S1298T|PLEC_uc003zac.1_Missense_Mutation_p.S1302T|PLEC_uc003zad.2_Missense_Mutation_p.S1298T|PLEC_uc003zae.1_Missense_Mutation_p.S1266T|PLEC_uc003zag.1_Missense_Mutation_p.S1276T|PLEC_uc003zah.2_Missense_Mutation_p.S1284T|PLEC_uc003zaj.2_Missense_Mutation_p.S1325T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1435	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TTGGCCGGGGAGGCCACCGGC	0.642													9	39					0	0	0	0	T	145001198	T	T	145001198	3	4	151	1	0	0	0	0	1	0	0	0	12107	304	11	5	9767	5	PLEC	8	145001198	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	13079145	145001198	1362824	59	27505											
GLDC	2731	broad.mit.edu	37	chr9	6587232	6587232	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctgatatccttgagcttGatccagaggcacaaaggggt	10	10	12	9	0	0	4	0	3	0	1	2	4	2	4	2	3	2	3	2	3	2	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr9:6587232G>A	uc003zkc.2	-	15	1952	c.1759C>T	c.(1759-1761)CAA>TAA	p.Q587*		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	587					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CCTTGAGCTTGATCCAGAGGC	0.393													32	54					0	0	0	0	A	6587232	A	A	6587232	4	1	151	1	0	0	0	0	0	1	0	0	6470	1299	45	2	1347	2	GLDC	9	6587232	Nonsense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08		6587232	134626199	60	27506											
ECM2	1842	broad.mit.edu	37	chr9	95280053	95280053	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcacatggtttcatcacAaagaactcttccatctgagc	12	11	7	11	0	4	2	2	1	2	1	5	2	5	2	1	2	2	2	1	2	2	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr9:95280053A>T	uc004ash.2	-	3	462	c.397T>A	c.(397-399)TGT>AGT	p.C133S	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Missense_Mutation_p.C133S|ECM2_uc011lty.1_Missense_Mutation_p.C133S|ECM2_uc004asg.2_Missense_Mutation_p.C133S|ECM2_uc011ltz.1_Missense_Mutation_p.C133S|ECM2_uc004asi.2_Missense_Mutation_p.C133S	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	133	VWFC.				cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						GTTTCATCACAAAGAACTCTT	0.522													58	69					0	0	0	0	T	95280053	T	T	95280053	3	4	151	1	0	0	0	0	1	0	0	0	4920	130	5	5	1734	5	ECM2	9	95280053	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	88692821	95280053	45933378	61	27507											
BSPRY	54836	broad.mit.edu	37	chr9	116130642	116130642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgacccaactctgggcaacgGcggttcttgggtctctctca	6	11	11	13	2	4	1	1	1	4	0	6	1	4	1	1	4	2	2	1	4	2	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr9:116130642G>A	uc004bhg.3	+	5	709	c.661G>A	c.(661-663)GCG>ACG	p.A221T	BSPRY_uc010muw.2_Intron	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	221	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						CTGGGCAACGGCGGTTCTTGG	0.527													8	90					0	0	0	0	A	116130642	A	A	116130642	3	1	151	1	0	0	0	0	1	0	0	0	1537	1203	42	4	679	4	BSPRY	9	116130642	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	20850589	116130642	25082789	62	27508											
SORCS1	114815	broad.mit.edu	37	chr10	108716285	108716285	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatacctccaaagcgagctCtctgtgatgctccccaggtt	9	10	8	14	1	1	1	0	1	1	0	4	2	3	1	4	1	4	3	4	1	2	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr10:108716285C>G	uc001kym.2	-	2	620	c.612G>C	c.(610-612)GAG>GAC	p.E204D	SORCS1_uc001kyl.2_Missense_Mutation_p.E204D|SORCS1_uc009xxs.2_Missense_Mutation_p.E204D|SORCS1_uc001kyn.1_Missense_Mutation_p.E204D|SORCS1_uc001kyo.2_Missense_Mutation_p.E204D	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	204	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AAAGCGAGCTCTCTGTGATGC	0.418													17	28					0	0	0	0	G	108716285	G	G	108716285	3	3	151	1	0	0	0	0	1	0	0	0	14994	912	32	2	3228	2	SORCS1	10	108716285	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08		108716285	26818462	63	27509											
BCCIP	56647	broad.mit.edu	37	chr10	127519144	127519144	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaatagcaaacggatgtttCagaagacagcaatgatgata	19	8	9	5	1	1	4	1	2	0	2	1	5	1	5	0	1	3	3	0	1	7	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr10:127519144C>T	uc001ljb.3	+	4	358	c.335C>T	c.(334-336)TCA>TTA	p.S112L	BCCIP_uc001ljd.3_Missense_Mutation_p.S112L|BCCIP_uc010qui.1_Missense_Mutation_p.S112L|BCCIP_uc001ljc.3_Missense_Mutation_p.S112L|BCCIP_uc010quj.1_Intron	NM_078468	NP_510868	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein isoform	112	Interaction with BRCA2.				cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				ACGGATGTTTCAGAAGACAGC	0.299													15	67					0	0	0	0	T	127519144	T	T	127519144	3	4	151	1	0	0	0	0	1	0	0	0	1358	838	29	2	349	2	BCCIP	10	127519144	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	18802859	127519144	8015603	64	27510											
TNKS1BP1	85456	broad.mit.edu	37	chr11	57080223	57080223	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagggtcacggcctcctcctCaacaggcagtgcctgtccag	7	8	11	15	1	2	0	2	0	0	0	5	0	5	0	5	3	2	1	5	3	2	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:57080223C>A	uc001njr.2	-	4	2251	c.1939G>T	c.(1939-1941)GAG>TAG	p.E647*	TNKS1BP1_uc001njs.2_Nonsense_Mutation_p.E647*|TNKS1BP1_uc009ymd.1_Nonsense_Mutation_p.E98*	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	647	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				GCCTCCTCCTCAACAGGCAGT	0.647													15	31					7.93312e-07	8.68355e-07	1	0	A	57080223	A	A	57080223	4	1	151	1	0	0	0	0	0	1	0	0	16386	835	29	2	3278	2	TNKS1BP1	11	57080223	Nonsense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08		57080223	77926293	65	27511											
DAGLA	747	broad.mit.edu	37	chr11	61505662	61505662	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctcctggatgtcctgcagCgaagcaccaagcccaaagtg	11	6	11	13	1	0	0	0	0	0	0	2	2	2	1	4	1	5	3	4	1	3	0			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:61505662C>T	uc001nsa.2	+	16	1750	c.1639C>T	c.(1639-1641)CGA>TGA	p.R547*		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	547	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		TGTCCTGCAGCGAAGCACCAA	0.642													10	39					0	0	0	0	T	61505662	T	T	61505662	4	4	151	1	0	0	0	0	0	1	0	0	4243	760	27	1	1697	1	DAGLA	11	61505662	Nonsense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	4425439	61505662	73500854	66	27512											
HNRNPUL2	221092	broad.mit.edu	37	chr11	62488775	62488775	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagattaatacctgatcaaGaataaagttcctctttgtcc	13	14	5	9	0	3	3	2	1	1	2	5	3	5	3	3	0	1	1	3	0	6	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:62488775G>A	uc001nuw.2	-	9	1796	c.1603C>T	c.(1603-1605)CTT>TTT	p.L535F	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	535					cell killing	nucleus	ATP binding|nucleic acid binding				0						ACCTGATCAAGAATAAAGTTC	0.428													11	295					0	0	0	0	A	62488775	A	A	62488775	3	1	151	1	0	0	0	0	1	0	0	0	7314	942	33	2	664	2	HNRNPUL2	11	62488775	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	983113	62488775	72517741	67	27513											
SIPA1	6494	broad.mit.edu	37	chr11	65417519	65417519	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctggagtcgctgtcccgaGagggtgaggccaccagggtg	6	8	17	10	2	1	2	0	1	1	1	3	4	2	3	3	4	0	1	3	4	0	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:65417519G>T	uc001ofb.2	+	13	3012	c.2845G>T	c.(2845-2847)GAG>TAG	p.E949*	SIPA1_uc010rom.1_Nonsense_Mutation_p.E847*|SIPA1_uc001ofd.2_Nonsense_Mutation_p.E949*	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	949					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						GCTGTCCCGAGAGGGTGAGGC	0.627													19	49					1.67942e-08	1.86346e-08	1	0	T	65417519	T	T	65417519	4	4	151	1	0	0	0	0	0	1	0	0	14393	943	33	2	2891	2	SIPA1	11	65417519	Nonsense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	2928744	65417519	69588997	68	27514											
EXPH5	23086	broad.mit.edu	37	chr11	108380358	108380358	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtccactgggtcatcctcaTagatattaagcggttcactt	10	13	8	10	1	3	1	3	0	0	1	5	1	5	1	2	2	1	1	2	2	3	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:108380358T>C	uc001pkk.2	-	6	5987	c.5876A>G	c.(5875-5877)TAT>TGT	p.Y1959C	EXPH5_uc010rvy.1_Missense_Mutation_p.Y1771C|EXPH5_uc010rvz.1_Missense_Mutation_p.Y1803C|EXPH5_uc010rwa.1_Missense_Mutation_p.Y1883C	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1959					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GTCATCCTCATAGATATTAAG	0.448													47	105					0	0	0	0	C	108380358	C	C	108380358	3	2	151	1	0	0	0	0	1	0	0	0	5347	1406	49	5	97	5	EXPH5	11	108380358	Missense_Mutation	SNP	T	TCGA-CR-7383-01A-11D-2129-08	42962839	108380358	26626158	69	27515											
OR4D5	219875	broad.mit.edu	37	chr11	123811134	123811134	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattccccatggacaaggccGtctctgtgctatacacaatt	10	11	7	13	1	1	0	0	0	1	0	3	1	2	1	3	2	2	1	3	2	4	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr11:123811134G>A	uc001pzk.1	+	1	811	c.811G>A	c.(811-813)GTC>ATC	p.V271I		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	271	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGACAAGGCCGTCTCTGTGCT	0.493													29	79					0	0	0	0	A	123811134	A	A	123811134	3	1	151	1	0	0	0	0	1	0	0	0	11111	1145	40	1	813	1	OR4D5	11	123811134	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	15430776	123811134	11195382	70	27516											
ACRBP	84519	broad.mit.edu	37	chr12	6753641	6753641	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtcggctcctgcctgtgCtccactccttgctcctgctt	1	15	9	16	1	0	0	0	0	0	0	5	0	4	0	5	1	4	4	5	1	0	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:6753641C>T	uc001qpu.1	-	5	654	c.606G>A	c.(604-606)GAG>GAA	p.E202E	ACRBP_uc010sfg.1_Silent_p.E169E	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	202						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						CCTGCCTGTGCTCCACTCCTT	0.378													17	78					0	0	0	0	T	6753641	T	T	6753641	2	4	151	1	0	0	0	0	0	0	0	1	170	796	28	4		4	ACRBP	12	6753641	Silent	SNP	C	TCGA-CR-7383-01A-11D-2129-08		6753641	127098254	71	27517											
PRH1	5554	broad.mit.edu	37	chr12	11126310	11126310	+	Translation_Start_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttccagcaggcaaaatattcTtctgcagcagctaggataag	13	10	9	9	0	2	0	0	0	2	0	3	1	3	1	1	2	4	5	1	2	5	6			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:11126310T>A	uc001qzc.2	-	4	474	c.-114A>T	c.(-116--112)GAAGA>GATGA		PRR4_uc009zhp.2_Missense_Mutation_p.K16M|PRH1_uc001qzb.3_RNA|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_RNA	NM_006250	NP_006241	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1							extracellular space	protein binding				0				BRCA - Breast invasive adenocarcinoma(232;0.245)		caaaatattcttctgcagcag	0.085													14	37					0	0	0	0	A	11126310	A	A	11126310	1	1	151	1	0	0	0	0	0	0	0	0	12544	1609	56	5		5	PRH1	12	11126310	Translation_Start_Site	SNP	T	TCGA-CR-7383-01A-11D-2129-08	4372669	11126310	122725585	72	27518											
PRB3	5544	broad.mit.edu	37	chr12	11421068	11421068	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcctccttgtgggcgtcGtccttctggctttcctggag	1	16	12	12	2	1	0	0	0	1	0	6	1	5	1	4	3	0	2	4	3	0	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:11421068G>A	uc001qzs.2	-	3	153	c.115C>T	c.(115-117)CGA>TGA	p.R39*	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	39	Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TGTGGGCGTCGTCCTTCTGGC	0.547													20	69					0	0	0	0	A	11421068	A	A	11421068	4	1	151	1	0	0	0	0	0	1	0	0	12506	1153	40	1	822	1	PRB3	12	11421068	Nonsense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	294758	11421068	122430827	73	27519											
PRB2	653247	broad.mit.edu	37	chr12	11545926	11545926	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccttgtggctttcctggAggagatcgggcacttcggga	5	11	16	9	2	0	1	0	0	0	1	4	4	2	3	2	6	0	2	2	6	0	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:11545926A>G	uc010shk.1	-	3	1121	c.1086T>C	c.(1084-1086)CCT>CCC	p.P362P		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GCTTTCCTGGAGGAGATCGGG	0.612													81	258					0	0	0	0	G	11545926	G	G	11545926	2	3	151	1	0	0	0	0	0	0	0	1	12505	291	11	5		5	PRB2	12	11545926	Silent	SNP	A	TCGA-CR-7383-01A-11D-2129-08	124858	11545926	122305969	74	27520											
GRIN2B	2904	broad.mit.edu	37	chr12	13828761	13828761	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catcttcactgaaggacaaaTtcctcccctcaaaagtgaca	14	9	5	13	0	3	2	2	2	1	0	5	3	5	3	3	1	0	0	3	1	4	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:13828761T>G	uc001rbt.2	-	4	1222	c.1043A>C	c.(1042-1044)AAT>ACT	p.N348T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	348	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAAGGACAAATTCCTCCCCTC	0.408													21	80					0	0	0	0	G	13828761	G	G	13828761	3	3	151	1	0	0	0	0	1	0	0	0	6819	1493	52	5	3451	5	GRIN2B	12	13828761	Missense_Mutation	SNP	T	TCGA-CR-7383-01A-11D-2129-08	2282835	13828761	120023134	75	27521											
LRRK2	120892	broad.mit.edu	37	chr12	40681270	40681270	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgtgctgtctaaatttgAtgaatggacctttattcctg	10	16	9	6	0	1	3	0	2	1	1	2	4	2	4	2	1	1	1	2	1	4	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:40681270A>T	uc001rmg.3	+	20	2739	c.2618A>T	c.(2617-2619)GAT>GTT	p.D873V	LRRK2_uc001rmh.1_Missense_Mutation_p.D495V	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	873					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCTAAATTTGATGAATGGACC	0.383													6	61					0	0	0	0	T	40681270	T	T	40681270	3	4	151	1	0	0	0	0	1	0	0	0	9083	333	12	5	2696	5	LRRK2	12	40681270	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	26852509	40681270	93170625	76	27522											
SCYL2	55681	broad.mit.edu	37	chr12	100728042	100728042	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catataatgcaagaacagcaGaagtaagtaggttgcacatg	17	8	10	6	0	0	2	0	0	0	2	0	2	0	2	0	1	4	6	0	1	7	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:100728042G>A	uc001thn.2	+	14	1910	c.1860G>A	c.(1858-1860)CAG>CAA	p.Q620Q	SCYL2_uc001thm.1_Silent_p.Q620Q	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	620					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						AAGAACAGCAGAAGTAAGTAG	0.338													20	55					0	0	0	0	A	100728042	A	A	100728042	2	1	151	1	0	0	0	0	0	0	0	1	14013	933	33	2		2	SCYL2	12	100728042	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08	60046772	100728042	33123853	77	27523											
CIT	11113	broad.mit.edu	37	chr12	120214570	120214570	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagattcgtagagatcactcCgtcttcttgctgagacaaga	11	11	9	10	2	3	4	1	1	2	4	5	6	4	4	1	0	1	2	1	0	2	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:120214570C>T	uc001txi.1	-	14	1795	c.1742G>A	c.(1741-1743)CGG>CAG	p.R581Q	CIT_uc001txh.1_Missense_Mutation_p.R115Q|CIT_uc001txj.1_Missense_Mutation_p.R581Q	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	581	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GAGATCACTCCGTCTTCTTGC	0.448													32	63					0	0	0	0	T	120214570	T	T	120214570	3	4	151	1	0	0	0	0	1	0	0	0	3453	652	23	1	4477	1	CIT	12	120214570	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	19486528	120214570	13637325	78	27524											
HNF1A	6927	broad.mit.edu	37	chr12	121432043	121432043	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcgtcacggaggtgcgtGtctacaactggtttgccaac	8	10	11	12	3	2	0	1	0	1	0	3	1	2	1	2	3	5	1	2	3	3	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr12:121432043G>A	uc001tzg.2	+	4	813	c.790G>A	c.(790-792)GTC>ATC	p.V264I	HNF1A_uc001tze.1_Missense_Mutation_p.V264I|HNF1A_uc001tzf.2_Missense_Mutation_p.V264I|HNF1A_uc010szn.1_Missense_Mutation_p.V264I	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	264	Homeobox; HNF1-type.|Interaction with DNA.				glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGAGGTGCGTGTCTACAACTG	0.647									Hepatic_Adenoma_Familial_Clustering_of				5	10					0	0	0	0	A	121432043	A	A	121432043	3	1	151	1	0	0	0	0	1	0	0	0	7290	1377	48	4	804	4	HNF1A	12	121432043	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	1217473	121432043	12419852	79	27525											
FLT1	2321	broad.mit.edu	37	chr13	28880897	28880897	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccaacagagtgctgctgtCgccctggtagtcctaggggg	6	8	16	11	1	0	1	0	0	0	1	2	1	1	1	3	4	3	3	3	4	3	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr13:28880897C>T	uc001usb.3	-	29	4018	c.3733G>A	c.(3733-3735)GAC>AAC	p.D1245N	FLT1_uc010aap.2_Missense_Mutation_p.D250N|FLT1_uc010aaq.2_Missense_Mutation_p.D370N|FLT1_uc001usa.3_Missense_Mutation_p.D463N	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1245	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GTGCTGCTGTCGCCCTGGTAG	0.552													12	52					0	0	0	0	T	28880897	T	T	28880897	3	4	151	1	0	0	0	0	1	0	0	0	5973	884	31	1	291	1	FLT1	13	28880897	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08		28880897	86288981	80	27526											
N4BP2L2	10443	broad.mit.edu	37	chr13	33091954	33091954	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaatttaatgattatttgtGacacagacacgattatgtga	14	15	7	5	1	0	4	0	3	0	1	0	5	0	4	0	0	0	0	0	0	4	6			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr13:33091954G>T	uc001uuk.3	-	6	1915	c.1737C>A	c.(1735-1737)GTC>GTA	p.V579V	N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010abe.1_Intron|N4BP2L2_uc010tdz.1_Intron	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	579											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GATTATTTGTGACACAGACAC	0.413													10	48					0.00829132	0.00855537	1	0	T	33091954	T	T	33091954	2	4	151	1	0	0	0	0	0	0	0	1	10165	1277	45	2		2	N4BP2L2	13	33091954	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08	4211057	33091954	82077924	81	27527											
OLFM4	10562	broad.mit.edu	37	chr13	53616150	53616150	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccatttcttacactgaactgGacttcgagctgatcaaggta	11	12	8	10	1	2	2	1	2	1	0	3	4	2	3	1	2	3	2	1	2	4	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr13:53616150G>T	uc001vhl.2	+	3	463	c.463G>T	c.(463-465)GAC>TAC	p.D155Y	OLFM4_uc001vhk.1_Missense_Mutation_p.D155Y	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	155	Potential.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		CACTGAACTGGACTTCGAGCT	0.403													20	70					5.26018e-13	6.00105e-13	1	0	T	53616150	T	T	53616150	3	4	151	1	0	0	0	0	1	0	0	0	10909	1174	41	2	473	2	OLFM4	13	53616150	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	20524196	53616150	61553728	82	27528											
GPC5	2262	broad.mit.edu	37	chr13	92560274	92560274	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaaggaattgatcctgtgaTaaatcagattattgataaac	17	12	7	5	0	1	4	1	3	0	1	2	5	2	5	1	1	1	0	1	1	7	5			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr13:92560274T>C	uc010tif.1	+	6	1730	c.1364T>C	c.(1363-1365)ATA>ACA	p.I455T		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	455						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GATCCTGTGATAAATCAGATT	0.358													19	27					0	0	0	0	C	92560274	C	C	92560274	3	2	151	1	0	0	0	0	1	0	0	0	6639	1406	49	5	1386	5	GPC5	13	92560274	Missense_Mutation	SNP	T	TCGA-CR-7383-01A-11D-2129-08	38944124	92560274	22609604	83	27529											
PTGER2	5732	broad.mit.edu	37	chr14	52794093	52794093	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgttcagtcctctgttgtcGgatttcattaagaacacaag	10	13	9	9	2	3	1	2	0	1	1	5	2	4	2	1	1	1	2	1	1	3	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr14:52794093G>A	uc001wzr.2	+	2	1249	c.998G>A	c.(997-999)CGG>CAG	p.R333Q		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	333	Cytoplasmic (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	CTCTGTTGTCGGATTTCATTA	0.408													15	90					0	0	0	0	A	52794093	A	A	52794093	3	1	151	1	0	0	0	0	1	0	0	0	12806	1116	39	1	1004	1	PTGER2	14	52794093	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08		52794093	54555447	84	27530											
C14orf102	55051	broad.mit.edu	37	chr14	90798195	90798195	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtgcttacctttcctggaGctcccgccatcgggagcctc	4	11	11	15	2	0	0	0	0	0	0	4	2	2	2	5	2	4	2	5	2	1	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr14:90798195G>T	uc001xyi.1	-	1	85	c.54C>A	c.(52-54)AGC>AGA	p.S18R	C14orf102_uc001xyj.1_5'UTR	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	18							protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		CTTTCCTGGAGCTCCCGCCAT	0.592													9	124					0.00448238	0.00465478	1	0	T	90798195	T	T	90798195	3	4	151	1	0	0	0	0	1	0	0	0	1741	962	34	4	3496	4	C14orf102	14	90798195	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	38004102	90798195	16551345	85	27531											
LGMN	5641	broad.mit.edu	37	chr14	93176022	93176022	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaccactactcacatccaGatgccgctggatctcctccg	8	10	6	17	2	3	1	2	0	1	1	6	2	5	2	5	1	2	1	5	1	1	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr14:93176022G>A	uc001yav.2	-	12	1341	c.1015C>T	c.(1015-1017)CTG>TTG	p.L339L	LGMN_uc001yat.2_Silent_p.L339L|LGMN_uc001yau.2_Silent_p.L339L|LGMN_uc001yaw.2_Silent_p.L339L|LGMN_uc010aul.2_Silent_p.L220L|LGMN_uc001yax.2_Silent_p.L339L|LGMN_uc001yay.2_Silent_p.L339L	NM_001008530	NP_001008530	Q99538	LGMN_HUMAN	legumain preproprotein	339					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			skin(1)	1		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		CTCACATCCAGATGCCGCTGG	0.592													37	112					0	0	0	0	A	93176022	A	A	93176022	2	1	151	1	0	0	0	0	0	0	0	1	8796	933	33	2		2	LGMN	14	93176022	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08	2377827	93176022	14173518	86	27532											
C14orf129	51527	broad.mit.edu	37	chr14	96851862	96851862	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgcatttctcttgtaggtGgtaggctatgcttttgacca	6	17	11	7	0	1	1	0	1	1	0	2	1	1	1	1	3	2	6	1	3	3	8			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr14:96851862G>A	uc001yfj.3	+	4	406	c.261G>A	c.(259-261)GTG>GTA	p.V87V	C14orf129_uc001yfl.2_Silent_p.V87V	NM_016472	NP_057556	Q9P0R6	GSKIP_HUMAN	chromosome 14 open reading frame 129	87						cytoplasm	protein binding				0		Melanoma(154;0.226)		Epithelial(152;0.109)|COAD - Colon adenocarcinoma(157;0.205)		TCTTGTAGGTGGTAGGCTATG	0.398													44	93					0	0	0	0	A	96851862	A	A	96851862	2	1	151	1	0	0	0	0	0	0	0	1	1750	1335	47	4		4	C14orf129	14	96851862	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08	3675840	96851862	10497678	87	27533											
ACSM2B	348158	broad.mit.edu	37	chr16	20559465	20559465	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagtttctggaagaagggaCtcccctccagcgaggcagtt	10	8	13	10	1	1	2	0	0	1	2	3	5	3	4	3	3	1	3	3	3	2	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr16:20559465C>T	uc002dhj.3	-	9	1227	c.1017G>A	c.(1015-1017)GAG>GAA	p.E339E	ACSM2B_uc002dhk.3_Silent_p.E339E|ACSM2B_uc010bwf.1_Silent_p.E339E	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	339					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GAAGAAGGGACTCCCCTCCAG	0.527													42	120					0	0	0	0	T	20559465	T	T	20559465	2	4	151	1	0	0	0	0	0	0	0	1	184	564	20	4		4	ACSM2B	16	20559465	Silent	SNP	C	TCGA-CR-7383-01A-11D-2129-08		20559465	69795288	88	27534											
TUBB3	10381	broad.mit.edu	37	chr16	89986164	89986164	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgggcgcggcgagccgttgcGgccatctgggtggccagtgt	3	7	19	12	6	1	0	0	0	1	0	1	1	1	0	3	5	2	1	3	5	0	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr16:89986164G>A	uc002fpf.2	+	1	906	c.498G>A	c.(496-498)GCG>GCA	p.A166A	MC1R_uc002fpe.3_Silent_p.A166A|TUBB3_uc010ciz.1_5'Flank	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	Error:Variant_position_missing_in_Q13509_after_alignment					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GAGCCGTTGCGGCCATCTGGG	0.647													13	50					0	0	0	0	A	89986164	A	A	89986164	2	1	151	1	0	0	0	0	0	0	0	1	16825	1103	39	1		1	TUBB3	16	89986164	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08	69426699	89986164	368589	89	27535											
TP53	7157	broad.mit.edu	37	chr17	7576852	7576852	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agaggtcccaagacttagtaCctgaagggtgaaatattctc	13	10	10	8	0	1	4	0	2	1	2	3	4	2	4	2	2	1	1	2	2	6	4	rs11575997		TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:7576852C>T	uc002gim.2	-	9	1187	c.993_splice	c.e9+1	p.Q331_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.Q331_splice|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_Splice_Site_p.Q199_splice|TP53_uc010cng.1_Splice_Site_p.Q199_splice|TP53_uc002gii.1_Splice_Site_p.Q199_splice|TP53_uc010cnh.1_Splice_Site_p.Q331_splice|TP53_uc010cni.1_Splice_Site_p.Q331_splice|TP53_uc002gij.2_Splice_Site_p.Q331_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(16)|p.0?(7)|p.I332fs*49(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGACTTAGTACCTGAAGGGTG	0.458		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			37	50					0	0	0	0	T	7576852	T	T	7576852	5	4	151	1	0	0	0	0	0	0	1	0	16448	521	18	4	288	4	TP53	17	7576852	Splice_Site	SNP	C	TCGA-CR-7383-01A-11D-2129-08		7576852	73618358	90	27536											
TEKT3	64518	broad.mit.edu	37	chr17	15231310	15231310	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatttcccccacatttaccGtcagcagttgtgcttcaact	8	13	6	14	1	2	0	2	0	0	0	3	0	3	0	3	0	4	4	3	0	2	5	rs143165525	byFrequency	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:15231310G>A	uc002gon.2	-	4	849	c.662C>T	c.(661-663)ACG>ATG	p.T221M		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	221					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		CACATTTACCGTCAGCAGTTG	0.383													27	89					0	0	0	0	A	15231310	A	A	15231310	3	1	151	1	0	0	0	0	1	0	0	0	15820	1159	40	1	834	1	TEKT3	17	15231310	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	7654458	15231310	65963900	91	27537											
C17orf63	55731	broad.mit.edu	37	chr17	27086837	27086837	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgcgaccttcttagcatacGcatccaattcggctggggta	8	12	10	11	3	1	0	0	0	1	0	3	1	2	0	2	3	3	4	2	3	4	6			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:27086837G>A	uc002hct.1	-	3	407	c.140C>T	c.(139-141)GCG>GTG	p.A47V	C17orf63_uc010wax.1_Missense_Mutation_p.A47V|C17orf63_uc010way.1_Missense_Mutation_p.A47V|C17orf63_uc002hcw.2_Intron	NM_018182	NP_060652	Q8WU58	CQ063_HUMAN	hypothetical protein LOC55731	47										ovary(1)	1	all_epithelial(6;5.06e-20)|Lung NSC(42;0.01)		Epithelial(11;3.38e-06)|all cancers(11;2.46e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.104)			CTTAGCATACGCATCCAATTC	0.393													3	12					0	0	0	0	A	27086837	A	A	27086837	3	1	151	1	0	0	0	0	1	0	0	0	1878	1087	38	1		1	C17orf63	17	27086837	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	11855527	27086837	54108373	92	27538											
ACACA	31	broad.mit.edu	37	chr17	35600294	35600294	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctataaatacctgctggCtgggaaactgacagaggact	13	9	10	9	0	0	2	0	1	0	1	1	4	1	4	2	3	3	2	2	3	5	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:35600294C>T	uc002hnm.2	-	22	3004	c.2813G>A	c.(2812-2814)AGC>AAC	p.S938N	ACACA_uc002hnk.2_Missense_Mutation_p.S860N|ACACA_uc002hnl.2_Missense_Mutation_p.S880N|ACACA_uc002hnn.2_Missense_Mutation_p.S938N|ACACA_uc002hno.2_Missense_Mutation_p.S975N|ACACA_uc010cuz.2_Missense_Mutation_p.S938N	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	938					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TACCTGCTGGCTGGGAAACTG	0.428													18	144					0	0	0	0	T	35600294	T	T	35600294	3	4	151	1	0	0	0	0	1	0	0	0	106	797	28	4	4367	4	ACACA	17	35600294	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	8513457	35600294	45594916	93	27539											
MAPT	4137	broad.mit.edu	37	chr17	44060805	44060805	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagggggcaaagagaggcCggggagcaaggaggaggtgg	11	1	24	5	1	0	1	0	0	0	1	0	5	0	4	1	10	1	3	1	10	2	0			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:44060805C>T	uc002ijr.3	+	6	955	c.635C>T	c.(634-636)CCG>CTG	p.P212L	MAPT_uc010dau.2_Missense_Mutation_p.P212L|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	212					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				AAAGAGAGGCCGGGGAGCAAG	0.692													6	18					0	0	0	0	T	44060805	T	T	44060805	3	4	151	1	0	0	0	0	1	0	0	0	9350	652	23	1	653	1	MAPT	17	44060805	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	8460511	44060805	37134405	94	27540											
BRIP1	83990	broad.mit.edu	37	chr17	59821801	59821801	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atttccagttacctttctctCctttgtatttgattgcgtca	6	20	5	10	1	2	1	1	1	1	0	5	1	4	1	3	0	2	2	3	0	2	7			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:59821801C>A	uc002izk.1	-	15	2390	c.2249G>T	c.(2248-2250)GGA>GTA	p.G750V	BRIP1_uc002izl.1_Missense_Mutation_p.G131V	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	750					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						ACCTTTCTCTCCTTTGTATTT	0.308			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				33	115					2.2871e-25	2.66554e-25	1	0	A	59821801	A	A	59821801	3	1	151	1	0	0	0	0	1	0	0	0	1519	855	30	2	1524	2	BRIP1	17	59821801	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	15760996	59821801	21373409	95	27541											
HELZ	9931	broad.mit.edu	37	chr17	65104673	65104673	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccagtctgccctcactggCggctgatgtaatcccagggg	6	10	12	13	1	2	1	1	1	1	0	4	1	4	1	3	4	1	2	3	4	1	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:65104673C>T	uc010wqk.1	-	30	4849	c.4662G>A	c.(4660-4662)CCG>CCA	p.P1554P	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.P1553P|HELZ_uc010der.2_Silent_p.P97P	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CCCTCACTGGCGGCTGATGTA	0.562													11	58					0	0	0	0	T	65104673	T	T	65104673	2	4	151	1	0	0	0	0	0	0	0	1	7088	755	27	1		1	HELZ	17	65104673	Silent	SNP	C	TCGA-CR-7383-01A-11D-2129-08	5282872	65104673	16090537	96	27542											
ITGB4	3691	broad.mit.edu	37	chr17	73725497	73725497	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcggcttcgatgccatcCtgcagacagctgtgtgcacg	7	8	14	12	3	0	1	0	0	0	1	2	2	1	1	2	2	4	4	2	2	0	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr17:73725497C>T	uc002jpg.2	+	7	905	c.718C>T	c.(718-720)CTG>TTG	p.L240L	ITGB4_uc002jph.2_Silent_p.L240L|ITGB4_uc010dgo.2_Silent_p.L240L|ITGB4_uc002jpi.3_Silent_p.L240L|ITGB4_uc010dgp.1_Silent_p.L240L|ITGB4_uc002jpj.2_Silent_p.L240L|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	240	VWFA.|Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGATGCCATCCTGCAGACAGC	0.622													10	38					0	0	0	0	T	73725497	T	T	73725497	2	4	151	1	0	0	0	0	0	0	0	1	7936	680	24	4		4	ITGB4	17	73725497	Silent	SNP	C	TCGA-CR-7383-01A-11D-2129-08	8620824	73725497	7469713	97	27543											
HRH4	59340	broad.mit.edu	37	chr18	22056762	22056762	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgaagattgttactctgatgGtggccgtttgggtgctggcc	5	14	15	7	1	1	3	0	2	1	1	1	3	1	3	2	4	2	3	2	4	2	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr18:22056762G>A	uc002kvi.2	+	3	509	c.409G>A	c.(409-411)GTG>ATG	p.V137M	HRH4_uc010xbd.1_3'UTR|HRH4_uc010dlx.2_Intron	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	137	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TACTCTGATGGTGGCCGTTTG	0.388													28	81					0	0	0	0	A	22056762	A	A	22056762	3	1	151	1	0	0	0	0	1	0	0	0	7397	1261	44	4	419	4	HRH4	18	22056762	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08		22056762	56020486	98	27544											
PMAIP1	5366	broad.mit.edu	37	chr18	57569917	57569917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctactcaactcaggagatttGgagacaaactgaacttccgg	13	9	9	10	1	2	3	2	1	0	2	3	5	3	3	1	3	4	0	1	3	4	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr18:57569917G>A	uc002lic.2	+	2	315	c.97G>A	c.(97-99)GGA>AGA	p.G33R	PMAIP1_uc002lid.2_Nonsense_Mutation_p.W83*	NM_021127	NP_066950	Q13794	APR_HUMAN	phorbol-12-myristate-13-acetate-induced protein	33	BH3.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to glucose starvation|cellular response to hypoxia|negative regulation of mitochondrial membrane potential|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of glucose metabolic process|positive regulation of protein oligomerization|positive regulation of release of cytochrome c from mitochondria|proteasomal protein catabolic process|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability|response to dsRNA|signal transduction by p53 class mediator resulting in induction of apoptosis|T cell homeostasis|virus-infected cell apoptosis	cytosol|mitochondrial outer membrane|nucleus	protein binding				0		Colorectal(73;0.0946)				CAGGAGATTTGGAGACAAACT	0.433													23	49					0	0	0	0	A	57569917	A	A	57569917	3	1	151	1	0	0	0	0	1	0	0	0	12185	1349	47	4	103	4	PMAIP1	18	57569917	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	35513155	57569917	20507331	99	27545											
ZBTB7A	51341	broad.mit.edu	37	chr19	4054997	4054997	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcctcggcgctgacgaaGtcgatctcgtacacgttctg	7	9	12	13	7	2	1	0	1	2	0	5	3	2	1	1	1	2	3	1	1	2	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:4054997G>C	uc002lzh.2	-	2	309	c.234C>G	c.(232-234)GAC>GAG	p.D78E	ZBTB7A_uc002lzi.2_Missense_Mutation_p.D78E	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	78	BTB.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCTGACGAAGTCGATCTCGT	0.662													5	35					0	0	0	0	C	4054997	C	C	4054997	3	2	151	1	0	0	0	0	1	0	0	0	17620	1020	36	4	1528	4	ZBTB7A	19	4054997	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08		4054997	55073986	100	27546											
TRIP10	9322	broad.mit.edu	37	chr19	6749986	6749986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgtctatgagaagacacCtcagatgggggaccccgcca	11	6	13	11	1	2	3	1	1	1	3	2	6	2	5	4	3	0	0	4	3	2	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:6749986C>T	uc002mfs.2	+	12	1370	c.1304C>T	c.(1303-1305)CCT>CTT	p.P435L	TRIP10_uc010dux.1_Missense_Mutation_p.P379L|TRIP10_uc002mfr.2_Missense_Mutation_p.P379L|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Missense_Mutation_p.P198L	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	435	Interaction with CDC42.|Interaction with PDE6G (By similarity).|REM.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						GAGAAGACACCTCAGATGGGG	0.468													32	103					0	0	0	0	T	6749986	T	T	6749986	3	4	151	1	0	0	0	0	1	0	0	0	16621	681	24	4	1178	4	TRIP10	19	6749986	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	2694989	6749986	52378997	101	27547											
SMARCA4	6597	broad.mit.edu	37	chr19	11134270	11134270	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcggcccttcttgctccgacGactcaagaaggaagtcgagg	9	7	13	12	4	2	1	1	0	1	1	4	5	3	2	2	3	1	1	2	3	3	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:11134270G>A	uc002mqf.3	+	20	3220	c.2936G>A	c.(2935-2937)CGA>CAA	p.R979Q	SMARCA4_uc010dxp.2_Missense_Mutation_p.R979Q|SMARCA4_uc010dxo.2_Missense_Mutation_p.R979Q|SMARCA4_uc002mqg.1_Missense_Mutation_p.R979Q|SMARCA4_uc010dxq.2_Missense_Mutation_p.R979Q|SMARCA4_uc010dxr.2_Missense_Mutation_p.R979Q|SMARCA4_uc002mqj.3_Missense_Mutation_p.R979Q|SMARCA4_uc010dxs.2_Missense_Mutation_p.R979Q|SMARCA4_uc010dxt.1_Missense_Mutation_p.R199Q|SMARCA4_uc002mqh.3_Missense_Mutation_p.R102Q|SMARCA4_uc002mqi.1_Missense_Mutation_p.R182Q	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	979					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TTGCTCCGACGACTCAAGAAG	0.577			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				8	17					0	0	0	0	A	11134270	A	A	11134270	3	1	151	1	0	0	0	0	1	0	0	0	14834	1058	37	1	3010	1	SMARCA4	19	11134270	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	4384284	11134270	47994713	102	27548											
CCDC151	115948	broad.mit.edu	37	chr19	11537572	11537572	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgcgccttcatctgggcCttctccaggcggttctccag	3	12	10	16	2	4	0	1	0	3	0	7	0	5	0	5	3	1	1	5	3	0	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:11537572C>T	uc002mrs.2	-	5	788	c.645G>A	c.(643-645)AAG>AAA	p.K215K	CCDC151_uc002mrr.2_Silent_p.K150K|CCDC151_uc010dxz.2_Intron	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	215	Potential.									ovary(1)	1						TCATCTGGGCCTTCTCCAGGC	0.627													7	25					0	0	0	0	T	11537572	T	T	11537572	2	4	151	1	0	0	0	0	0	0	0	1	2798	680	24	4		4	CCDC151	19	11537572	Silent	SNP	C	TCGA-CR-7383-01A-11D-2129-08	403302	11537572	47591411	103	27549											
DDX39	10212	broad.mit.edu	37	chr19	14521049	14521049	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgcatgaacttcctgcaCacaggccggatgtccttgct	7	11	9	14	1	0	1	0	1	0	0	3	2	3	2	4	2	4	3	4	2	1	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:14521049C>A	uc010xnp.1	-	6	756	c.711G>T	c.(709-711)GTG>GTT	p.V237V	DDX39_uc002myo.2_Silent_p.V237V|DDX39_uc010dzl.2_RNA|DDX39_uc010dzm.1_Silent_p.V237V	NM_005804	NP_005795	O00148	DX39A_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39	237	Helicase ATP-binding.				mRNA export from nucleus|nuclear mRNA splicing, via spliceosome	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding				0						ACTTCCTGCACACAGGCCGGA	0.632													14	52					6.72482e-11	7.56543e-11	1	0	A	14521049	A	A	14521049	2	1	151	1	0	0	0	0	0	0	0	1	4374	465	17	4		4	DDX39	19	14521049	Silent	SNP	C	TCGA-CR-7383-01A-11D-2129-08	2983477	14521049	44607934	104	27550											
ABHD8	79575	broad.mit.edu	37	chr19	17411760	17411760	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcatagaaggtgtaggctgcGgccacctggggcgcagagct	8	6	17	10	2	0	2	0	0	0	2	0	2	0	2	2	5	2	5	2	5	3	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:17411760G>A	uc002ngb.3	-	2	906	c.666C>T	c.(664-666)GCC>GCT	p.A222A		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	222							hydrolase activity				0						TGTAGGCTGCGGCCACCTGGG	0.602													5	90					0	0	0	0	A	17411760	A	A	17411760	2	1	151	1	0	0	0	0	0	0	0	1	87	1103	39	1		1	ABHD8	19	17411760	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08	2890711	17411760	41717223	105	27551											
FXYD5	53827	broad.mit.edu	37	chr19	35657174	35657174	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgaacacaccctccggaaaCgggggctgttggtcgcagct	9	7	13	12	3	0	1	0	1	0	0	2	2	1	2	2	4	3	4	2	4	2	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:35657174C>T	uc002nyg.1	+	8	519	c.433C>T	c.(433-435)CGG>TGG	p.R145W	FXYD5_uc010xsq.1_Missense_Mutation_p.R145W|FXYD5_uc002nyh.1_Missense_Mutation_p.R145W|FXYD5_uc002nyi.1_Missense_Mutation_p.R82W|FXYD5_uc002nyj.1_5'Flank	NM_014164	NP_054883	Q96DB9	FXYD5_HUMAN	FXYD domain-containing ion transport regulator 5	145	Extracellular (Potential).				microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity				0	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CCTCCGGAAACGGGGGCTGTT	0.552													33	205					0	0	0	0	T	35657174	T	T	35657174	3	4	151	1	0	0	0	0	1	0	0	0	6155	527	19	1	459	1	FXYD5	19	35657174	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	18245414	35657174	23471809	106	27552											
ZNF461	92283	broad.mit.edu	37	chr19	37129598	37129598	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggaggagaggaaacctgActggcttctcgccagtatga	11	7	15	8	1	1	3	0	2	1	1	2	7	1	5	2	4	1	2	2	4	2	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:37129598A>T	uc002oem.2	-	6	1877	c.1649T>A	c.(1648-1650)GTC>GAC	p.V550D	ZNF461_uc002oen.2_Missense_Mutation_p.V519D|ZNF461_uc010xtj.1_Missense_Mutation_p.V527D	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	550					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGGAAACCTGACTGGCTTCTC	0.378													4	13					0	0	0	0	T	37129598	T	T	37129598	3	4	151	1	0	0	0	0	1	0	0	0	17992	275	10	5	46	5	ZNF461	19	37129598	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	1472424	37129598	21999385	107	27553											
LIPE	3991	broad.mit.edu	37	chr19	42930494	42930494	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccactgtatcctgacatcaCtttataaccagattttcctt	10	15	3	13	0	1	2	1	1	0	1	3	2	3	2	4	0	1	1	4	0	3	7			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:42930494C>T	uc002otr.2	-	1	1085	c.808G>A	c.(808-810)GTG>ATG	p.V270M	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|LIPE_uc002ots.1_5'Flank	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	270					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				CCTGACATCACTTTATAACCA	0.488													28	120					0	0	0	0	T	42930494	T	T	42930494	3	4	151	1	0	0	0	0	1	0	0	0	8863	565	20	4	2462	4	LIPE	19	42930494	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	5800896	42930494	16198489	108	27554											
TRAPPC6A	79090	broad.mit.edu	37	chr19	45681404	45681404	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcgctcacccccgggccggGgtcggggtcgtgagcccaca	4	4	17	16	5	1	1	1	1	0	0	3	1	1	1	4	6	1	1	4	6	0	0			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:45681404G>T	uc002paw.2	-	1	92	c.73C>A	c.(73-75)CCC>ACC	p.P25T	TRAPPC6A_uc002pav.2_Missense_Mutation_p.P25T|BLOC1S3_uc002pax.3_5'Flank			O75865	TPC6A_HUMAN	SubName: Full=TRAPPC6Adelta29-42; SubName: Full=Trafficking protein particle complex 6A, isoform CRA_a;	25					vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	guanylate cyclase activity|heme binding				0		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00872)|GBM - Glioblastoma multiforme(486;0.233)		CCCGGGCCGGGGTCGGGGTCG	0.612													7	22					0.00448238	0.00465478	1	0	T	45681404	T	T	45681404	3	4	151	1	0	0	0	0	1	0	0	0	16530	1232	43	4	472	4	TRAPPC6A	19	45681404	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	2750910	45681404	13447579	109	27555											
SNRPD2	6633	broad.mit.edu	37	chr19	46191786	46191786	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctcgcttctgcagctccTctggggtcatctcactcttg	3	14	8	16	1	6	0	2	0	5	0	9	0	7	0	2	2	2	3	2	2	0	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:46191786T>G	uc002pcw.2	-	2	338	c.41A>C	c.(40-42)GAG>GCG	p.E14A	SNRPD2_uc002pcv.2_Missense_Mutation_p.E4A	NM_004597	NP_004588	P62316	SMD2_HUMAN	small nuclear ribonucleoprotein D2 isoform 1	14					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00546)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.194)		CTGCAGCTCCTCTGGGGTCAT	0.532													16	134					0	0	0	0	G	46191786	G	G	46191786	3	3	151	1	0	0	0	0	1	0	0	0	14929	1551	54	5	323	5	SNRPD2	19	46191786	Missense_Mutation	SNP	T	TCGA-CR-7383-01A-11D-2129-08	510382	46191786	12937197	110	27556											
SCAF1	58506	broad.mit.edu	37	chr19	50157990	50157990	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctttgggtctgccccctggcCcctccagctacctgcttcct	2	12	8	19	0	1	0	0	0	1	0	3	0	3	0	7	2	4	2	7	2	1	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:50157990C>T	uc002poq.2	+	9	3605	c.3481C>T	c.(3481-3483)CCC>TCC	p.P1161S		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1161					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GCCCCCTGGCCCCTCCAGCTA	0.672													7	99					0	0	0	0	T	50157990	T	T	50157990	3	4	151	1	0	0	0	0	1	0	0	0	13933	623	22	4	3511	4	SCAF1	19	50157990	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	3966204	50157990	8970993	111	27557											
KLK8	11202	broad.mit.edu	37	chr19	51506324	51506324	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accccctaccccgtgcccttCggcctctcttggtcttccaa	4	11	6	20	2	2	0	0	0	2	0	5	0	3	0	7	2	2	0	7	2	2	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:51506324C>T	uc002pur.1	-						KLK9_uc002puw.1_RNA|KLK9_uc010eol.1_3'UTR|KLK9_uc002pux.1_3'UTR|KLK8_uc002puq.1_5'Flank|KLK8_uc002pus.1_5'Flank|KLK8_uc002put.1_5'Flank|KLK8_uc002puu.1_5'UTR|KLK9_uc002puv.1_RNA	NM_007196	NP_009127	O60259	KLK8_HUMAN	kallikrein 8 isoform 1 preproprotein						cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		CCGTGCCCTTCGGCCTCTCTT	0.617													17	160					0	0	0	0	T	51506324	T	T	51506324	1	4	151	0	1	0	0	0	0	0	0	0	8449	899	31	1		1	KLK8	19	51506324	5'Flank	SNP	C	TCGA-CR-7383-01A-11D-2129-08	1348334	51506324	7622659	112	27558											
SIGLEC10	89790	broad.mit.edu	37	chr19	51919567	51919567	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccgacggccctcagtacctgGcgtgttgtcacgtgaaatgc	7	9	12	13	4	2	1	2	1	0	0	2	2	2	1	3	2	2	2	3	2	2	2	rs147122969	byFrequency	TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:51919567G>A	uc002pwo.2	-	4	1367	c.751C>T	c.(751-753)CCA>TCA	p.P251S	SIGLEC10_uc002pwp.2_Missense_Mutation_p.P193S|SIGLEC10_uc002pwq.2_Missense_Mutation_p.P193S|SIGLEC10_uc002pwr.2_Missense_Mutation_p.P251S|SIGLEC10_uc010ycy.1_Missense_Mutation_p.P251S|SIGLEC10_uc010ycz.1_Missense_Mutation_p.P203S|SIGLEC10_uc010eow.2_Silent_p.R15R|SIGLEC10_uc002pws.1_Missense_Mutation_p.P177S	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	251	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		TCAGTACCTGGCGTGTTGTCA	0.483													6	136					0	0	0	0	A	51919567	A	A	51919567	3	1	151	1	0	0	0	0	1	0	0	0	14371	1203	42	4	1374	4	SIGLEC10	19	51919567	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	413243	51919567	7209416	113	27559											
LILRA4	23547	broad.mit.edu	37	chr19	54848719	54848719	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggccgaccactcggaggAgacgttgtgtgcgccgtagc	6	6	18	11	5	0	1	0	0	0	1	1	4	0	2	3	4	2	2	3	4	1	2			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr19:54848719A>G	uc002qfj.2	-	5	961	c.904T>C	c.(904-906)TCC>CCC	p.S302P	LILRA4_uc002qfi.2_Missense_Mutation_p.S236P	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	302	Extracellular (Potential).|Ig-like C2-type 3.					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CACTCGGAGGAGACGTTGTGT	0.682													8	31					0	0	0	0	G	54848719	G	G	54848719	3	3	151	1	0	0	0	0	1	0	0	0	8828	304	11	5	611	5	LILRA4	19	54848719	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	2929152	54848719	4280264	114	27560											
MATN4	8785	broad.mit.edu	37	chr20	43926821	43926822	+	Frame_Shift_Del	DEL	GC	-	-																															caagcccaccttcctccttgGcgcgcgctgcccacaccgag																										TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr20:43926821_43926822delGC	uc002xnn.2	-	7	1601_1602	c.1414_1415delGC	c.(1414-1416)GCCfs	p.A472fs	MATN4_uc002xno.2_Frame_Shift_Del_p.A431fs|MATN4_uc002xnp.2_Frame_Shift_Del_p.A390fs|MATN4_uc010zwr.1_Frame_Shift_Del_p.A420fs|MATN4_uc002xnr.1_Frame_Shift_Del_p.A472fs	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	513	VWFA 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				TTCCTCCTTGGCGCGCGCTGCC	0.683													---	---	---								-	43926822	-	-	43926821	7	5	151	1	0	1	0	1	0	0	0	0	9389	1203	42	0	346	0	MATN4	20	43926821	Frame_Shift_Del	DEL	GC	TCGA-CR-7383-01A-11D-2129-08		43926821	19098699	115	27561											
RTEL1	51750	broad.mit.edu	37	chr20	62326202	62326202	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcccgcagggccctggggtCcgcgggctgtagccaactct	4	7	15	15	3	1	0	0	0	1	0	2	0	2	0	4	4	3	3	4	4	2	1			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr20:62326202C>T	uc002yfu.1	+	32	3561	c.3218C>T	c.(3217-3219)TCC>TTC	p.S1073F	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.S1073F|RTEL1_uc011abd.1_Missense_Mutation_p.S1097F|RTEL1_uc011abe.1_Missense_Mutation_p.S850F|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_Missense_Mutation_p.S318F|TNFRSF6B_uc002yfy.2_5'Flank|TNFRSF6B_uc002yfz.2_5'Flank	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	1073					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GCCCTGGGGTCCGCGGGCTGT	0.662													5	52					0	0	0	0	T	62326202	T	T	62326202	3	4	151	1	0	0	0	0	1	0	0	0	13785	855	30	2	3340	2	RTEL1	20	62326202	Missense_Mutation	SNP	C	TCGA-CR-7383-01A-11D-2129-08	18399381	62326202	699318	116	27562											
BRWD1	54014	broad.mit.edu	37	chr21	40650700	40650700	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaacaaagcatttgaacGcctggcctaggcttttcagt	12	10	10	9	1	1	2	1	1	0	1	1	3	1	2	2	2	3	2	2	2	5	4			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chr21:40650700G>A	uc002yxk.1	-	10	1111	c.972C>T	c.(970-972)GGC>GGT	p.G324G	BRWD1_uc002yxl.2_Silent_p.G324G|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_5'UTR|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Silent_p.G44G	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	324	WD 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GCATTTGAACGCCTGGCCTAG	0.333													33	79					0	0	0	0	A	40650700	A	A	40650700	2	1	151	1	0	0	0	0	0	0	0	1	1530	1074	38	1		1	BRWD1	21	40650700	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08		40650700	7479195	117	27563											
POF1B	79983	broad.mit.edu	37	chrX	84585990	84585990	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaaatgttctaataagcaGtgatatagatccgtattctt	13	15	7	6	1	2	2	0	1	2	1	3	2	3	2	1	0	2	4	1	0	6	8			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chrX:84585990G>A	uc004eer.2	-	7	965	c.819C>T	c.(817-819)CAC>CAT	p.H273H	POF1B_uc004ees.2_Silent_p.H273H	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	273							actin binding				0						CTAATAAGCAGTGATATAGAT	0.378													21	44					0	0	0	0	A	84585990	A	A	84585990	2	1	151	1	0	0	0	0	0	0	0	1	12237	1020	36	4		4	POF1B	23	84585990	Silent	SNP	G	TCGA-CR-7383-01A-11D-2129-08		84585990	70684570	118	27564											
TNMD	64102	broad.mit.edu	37	chrX	99852545	99852545	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttgaacagtcagtgatttgGgtcccagcagaaaagcctat	12	11	10	8	0	1	3	1	2	0	1	2	3	2	3	2	1	3	1	2	1	4	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chrX:99852545G>C	uc004efy.3	+	5	694	c.468G>C	c.(466-468)TGG>TGC	p.W156C	TNMD_uc004efz.2_Missense_Mutation_p.W156C	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	156	Extracellular (Potential).|BRICHOS.					integral to membrane				central_nervous_system(1)	1						CAGTGATTTGGGTCCCAGCAG	0.373													11	99					0	0	0	0	C	99852545	C	C	99852545	3	2	151	1	0	0	0	0	1	0	0	0	16388	1241	43	4	486	4	TNMD	23	99852545	Missense_Mutation	SNP	G	TCGA-CR-7383-01A-11D-2129-08	15266555	99852545	55418015	119	27565											
XKRX	402415	broad.mit.edu	37	chrX	100177997	100177997	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggctgacatagggctccTcctgctcctctttcttccac	5	13	8	15	0	2	2	0	2	2	0	6	2	6	2	4	2	1	3	4	2	1	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chrX:100177997T>A	uc004egn.2	-	2	994	c.389A>T	c.(388-390)GAG>GTG	p.E130V	XKRX_uc011mre.1_Intron	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	130						integral to membrane|plasma membrane				breast(1)	1						ATAGGGCTCCTCCTGCTCCTC	0.507													88	135					0	0	0	0	A	100177997	A	A	100177997	3	1	151	1	0	0	0	0	1	0	0	0	17507	1551	54	5	968	5	XKRX	23	100177997	Missense_Mutation	SNP	T	TCGA-CR-7383-01A-11D-2129-08	325452	100177997	55092563	120	27566											
TCEAL2	140597	broad.mit.edu	37	chrX	101382142	101382142	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtgaaagagagccagagAgtgagggagagccagaaagt	17	3	16	5	0	0	6	0	2	0	4	0	9	0	6	2	1	2	0	2	1	2	0			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chrX:101382142A>T	uc004eip.2	+	3	559	c.340A>T	c.(340-342)AGT>TGT	p.S114C		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						agagccagagagtgagggaga	0.229													33	36					0	0	0	0	T	101382142	T	T	101382142	3	4	151	1	0	0	0	0	1	0	0	0	15737	304	11	5	342	5	TCEAL2	23	101382142	Missense_Mutation	SNP	A	TCGA-CR-7383-01A-11D-2129-08	1204145	101382142	53888418	121	27567											
COL4A5	1287	broad.mit.edu	37	chrX	107909817	107909817	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccagctggacagaagggTgaaccaggtgctgtagtttt	10	9	15	7	0	0	2	0	1	0	1	0	4	0	4	2	4	3	4	2	4	3	3			TCGA-CR-7383-01A-11D-2129-08	TCGA-CR-7383-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	203629ed-2791-4e22-a9da-be647b0cdef5	62ea230c-402e-4a2d-b617-f909b4fad7d7	g.chrX:107909817T>C	uc004enz.1	+	39	3748	c.3546T>C	c.(3544-3546)GGT>GGC	p.G1182G	COL4A5_uc011mso.1_Silent_p.G1182G	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1182	Triple-helical region.		G -> R (in APSX; juvenile type).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GACAGAAGGGTGAACCAGGTG	0.428									Alport_syndrome_with_Diffuse_Leiomyomatosis				20	14					0	0	0	0	C	107909817	C	C	107909817	2	2	151	1	0	0	0	0	0	0	0	1	3709	1683	59	5		5	COL4A5	23	107909817	Silent	SNP	T	TCGA-CR-7383-01A-11D-2129-08	6527675	107909817	47360743	122	27568											
MACF1	23499	broad.mit.edu	37	chr1	39903546	39903546	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctgaagtagacaagatcaGagagtgcatcagtgacaata	16	8	11	6	0	2	5	2	2	0	3	2	6	2	5	0	0	2	3	0	0	5	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:39903546G>C	uc010oiu.1	+	36	13546	c.13415G>C	c.(13414-13416)AGA>ACA	p.R4472T	MACF1_uc010ois.1_Missense_Mutation_p.R3970T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GACAAGATCAGAGAGTGCATC	0.488													3	134					0	0	0	0	C	39903546	C	C	39903546	3	2	152	1	0	0	0	0	1	0	0	0	9195	942	33	2	18326	2	MACF1	1	39903546	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08		39903546	209347075	1	27569											
RAVER2	55225	broad.mit.edu	37	chr1	65243359	65243359	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaacgcaattcagatgtttCatcaatattcttttagagga	14	14	7	6	1	4	3	3	0	1	3	4	4	4	4	0	1	1	2	0	1	5	6			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:65243359C>G	uc001dbs.1	+	3	448	c.370C>G	c.(370-372)CAT>GAT	p.H124D	RAVER2_uc001dbt.1_Missense_Mutation_p.H3D|RAVER2_uc010opb.1_Missense_Mutation_p.H3D	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	124	RRM 1.					cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						TCAGATGTTTCATCAATATTC	0.328													3	111					0	0	0	0	G	65243359	G	G	65243359	3	3	152	1	0	0	0	0	1	0	0	0	13160	826	29	2	380	2	RAVER2	1	65243359	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	25339813	65243359	184007262	2	27570											
FCGR1A	2209	broad.mit.edu	37	chr1	149761632	149761632	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctatttccagctccagtgctGaatgcatctgtgacatcccc	8	12	7	14	0	1	2	0	2	1	0	4	2	4	2	4	0	3	3	4	0	2	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:149761632G>A	uc001esp.3	+	5	632	c.582G>A	c.(580-582)CTG>CTA	p.L194L	HIST2H2BF_uc010pbj.1_Intron|FCGR1A_uc009wlg.2_Intron	NM_000566	NP_000557	P12314	FCGR1_HUMAN	Fc fragment of IgG, high affinity Ia, receptor	194	Extracellular (Potential).|Ig-like C2-type 3.				interferon-gamma-mediated signaling pathway|phagocytosis, engulfment	integral to membrane|plasma membrane	IgG binding|receptor activity|receptor signaling protein activity			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)				Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Methyl aminolevulinate(DB00992)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Porfimer(DB00707)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CTCCAGTGCTGAATGCATCTG	0.498													5	65					0	0	0	0	A	149761632	A	A	149761632	2	1	152	1	0	0	0	0	0	0	0	1	5811	1277	45	2		2	FCGR1A	1	149761632	Silent	SNP	G	TCGA-CR-7385-01A-11D-2012-08	84518273	149761632	99488989	3	27571											
HRNR	388697	broad.mit.edu	37	chr1	152191393	152191393	+	Silent	SNP	G	T	T																															gacccatgtcggccatagctGggagactgccctgacccaga																										TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:152191393G>T	uc001ezt.1	-	3	2788	c.2712C>A	c.(2710-2712)CCC>CCA	p.P904P		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	904	10.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCATAGCTGGGAGACTGCC	0.647													30	175					3.99451e-17	4.89327e-16	1	0	T	152191393	T	T	152191393	2	4	152	1	0	0	0	0	0	0	0	1	7398	1335	47	4		4	HRNR	1	152191393	Silent	SNP	G	TCGA-CR-7385-01A-11D-2012-08	2429761	152191393	97059228	4	27572	55	2									
HRNR	388697	broad.mit.edu	37	chr1	152191395	152191395	+	Missense_Mutation	SNP	G	C	C																															cccatgtcggccatagctggGagactgccctgacccagacc																										TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:152191395G>C	uc001ezt.1	-	3	2786	c.2710C>G	c.(2710-2712)CCC>GCC	p.P904A		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	904	10.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATAGCTGGGAGACTGCCCT	0.647													27	171					0	0	0	0	C	152191395	C	C	152191395	3	2	152	1	0	0	0	0	1	0	0	0	7398	1174	41	2	5846	2	HRNR	1	152191395	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	2	152191395	97059226	5	27573	55	2									
ZBTB7B	51043	broad.mit.edu	37	chr1	154987971	154987971	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctatgagggtgaggaagaaGaagaggagctggtatatccc	13	7	15	6	0	0	5	0	2	0	3	1	7	1	7	2	4	1	2	2	4	6	3			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:154987971G>A	uc001fgk.3	+	3	993	c.835G>A	c.(835-837)GAA>AAA	p.E279K	ZBTB7B_uc009wpa.2_Missense_Mutation_p.E279K|ZBTB7B_uc001fgj.3_Missense_Mutation_p.E313K|ZBTB7B_uc010peq.1_Missense_Mutation_p.E313K|ZBTB7B_uc001fgl.3_Missense_Mutation_p.E279K	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	279					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGAGGAAGAAGAAGAGGAGCT	0.657													6	29					0	0	0	0	A	154987971	A	A	154987971	3	1	152	1	0	0	0	0	1	0	0	0	17621	943	33	2	837	2	ZBTB7B	1	154987971	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	2796576	154987971	94262650	6	27574											
PPFIA4	8497	broad.mit.edu	37	chr1	203017400	203017400	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggagcacctgcggcagctgGagggacagctggaggagaag	11	3	19	8	1	0	1	0	0	0	1	0	6	0	5	1	6	4	4	1	6	1	0			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:203017400G>A	uc001gyz.2	+						PPFIA4_uc009xaj.2_Missense_Mutation_p.E543K|PPFIA4_uc010pqf.1_Missense_Mutation_p.E103K|PPFIA4_uc001gza.2_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f						cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GCGGCAGCTGGAGGGACAGCT	0.672													6	36					0	0	0	0	A	203017400	A	A	203017400	1	1	152	0	1	0	0	0	0	0	0	0	12367	1189	41	2		2	PPFIA4	1	203017400	5'Flank	SNP	G	TCGA-CR-7385-01A-11D-2012-08	48029429	203017400	46233221	7	27575											
TRAF5	7188	broad.mit.edu	37	chr1	211545470	211545470	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttttttttcttatttgcagCcgttttagaagaggaaacta	10	19	7	5	1	1	2	0	0	1	2	1	3	1	3	1	1	3	2	1	1	5	9			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:211545470C>A	uc001hih.2	+	11	1160	c.1100C>A	c.(1099-1101)GCC>GAC	p.A367D	TRAF5_uc001hii.2_Missense_Mutation_p.A367D|TRAF5_uc010psx.1_Missense_Mutation_p.A378D|TRAF5_uc010psy.1_Missense_Mutation_p.A261D|TRAF5_uc001hij.2_Missense_Mutation_p.A367D	NM_004619	NP_004610	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	367					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(2)|ovary(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		TTATTTGCAGCCGTTTTAGAA	0.318													17	52					3.41278e-10	4.12339e-09	1	0	A	211545470	A	A	211545470	3	1	152	1	0	0	0	0	1	0	0	0	16511	753	26	4	1138	4	TRAF5	1	211545470	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	8528070	211545470	37705151	8	27576											
SMYD2	56950	broad.mit.edu	37	chr1	214478569	214478569	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggaagatgcaagcaggcAttttactgcaatgtggagtg	11	11	14	5	0	0	1	0	0	0	1	0	3	0	3	0	3	4	4	0	3	4	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:214478569A>C	uc010ptx.1	+	2	246	c.213A>C	c.(211-213)GCA>GCC	p.A71A	SMYD2_uc009xdj.2_Intron|SMYD2_uc010ptw.1_Intron|SMYD2_uc009xdl.1_RNA	NM_020197	NP_064582	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	71	MYND-type.				negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		GCAAGCAGGCATTTTACTGCA	0.473													32	109					0	0	0	0	C	214478569	C	C	214478569	2	2	152	1	0	0	0	0	0	0	0	1	14886	204	8	5		5	SMYD2	1	214478569	Silent	SNP	A	TCGA-CR-7385-01A-11D-2012-08	2933099	214478569	34772052	9	27577											
SCN2A	6326	broad.mit.edu	37	chr2	166170610	166170610	+	Frame_Shift_Del	DEL	G	-	-																															agttgaaaaagcaacaagaaGaagctcaggtatagtgaaca																										TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr2:166170610delG	uc002udc.2	+	10	1665	c.1375delG	c.(1375-1377)GAAfs	p.E459fs	SCN2A_uc002udd.2_Frame_Shift_Del_p.E459fs|SCN2A_uc002ude.2_Frame_Shift_Del_p.E459fs	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	459					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	GCAACAAGAAGAAGCTCAGGT	0.408													---	---	---								-	166170610	-	-	166170610	7	5	152	1	0	1	0	1	0	0	0	0	13981	943	33	0	1505	0	SCN2A	2	166170610	Frame_Shift_Del	DEL	G	TCGA-CR-7385-01A-11D-2012-08		166170610	77028763	10	27578											
CHRND	1144	broad.mit.edu	37	chr2	233393036	233393036	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacatcagtgtcctgcgccTccccccggacatggtgtggc	7	8	11	15	2	1	0	1	0	0	0	3	1	3	1	5	3	2	0	5	3	1	0			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr2:233393036T>C	uc002vsw.2	+	4	312	c.308T>C	c.(307-309)CTC>CCC	p.L103P	CHRND_uc010zmg.1_Missense_Mutation_p.L88P|CHRND_uc010fyc.2_Missense_Mutation_p.S13P|CHRND_uc010zmh.1_Missense_Mutation_p.S13P	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	103	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GTCCTGCGCCTCCCCCCGGAC	0.567													3	56					0	0	0	0	C	233393036	C	C	233393036	3	2	152	1	0	0	0	0	1	0	0	0	3409	1551	54	5	322	5	CHRND	2	233393036	Missense_Mutation	SNP	T	TCGA-CR-7385-01A-11D-2012-08	67222426	233393036	9806337	11	27579											
MTMR14	64419	broad.mit.edu	37	chr3	9726305	9726305	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtacactgtatctcaggctGggatcggacccccctcttca	7	10	10	14	1	3	0	2	0	2	0	5	2	3	2	3	4	1	3	3	4	2	3			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr3:9726305G>C	uc003brz.2	+	11	1125	c.1001G>C	c.(1000-1002)TGG>TCG	p.W334S	MTMR14_uc003bsa.2_Missense_Mutation_p.W334S|MTMR14_uc003bsb.2_Missense_Mutation_p.W334S|MTMR14_uc011ath.1_RNA|MTMR14_uc010hcl.2_Missense_Mutation_p.W88S|MTMR14_uc003bsc.2_RNA	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	334						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					ATCTCAGGCTGGGATCGGACC	0.577													4	80					0	0	0	0	C	9726305	C	C	9726305	3	2	152	1	0	0	0	0	1	0	0	0	9995	1357	47	4	1043	4	MTMR14	3	9726305	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08		9726305	188296125	12	27580											
NKTR	4820	broad.mit.edu	37	chr3	42679772	42679772	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgccctcattcaaaaaaaaGaactttgaaagagaatcttt	18	11	5	7	0	3	3	2	1	1	2	3	4	3	3	1	0	2	0	1	0	7	3			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr3:42679772G>A	uc003clo.2	+	13	2723	c.2576G>A	c.(2575-2577)AGA>AAA	p.R859K	NKTR_uc003clm.1_Missense_Mutation_p.R606K|NKTR_uc003clp.2_Missense_Mutation_p.R606K|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R749K|NKTR_uc003clr.1_Missense_Mutation_p.R606K|NKTR_uc003cls.2_Missense_Mutation_p.R559K	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	859					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TCAAAAAAAAGAACTTTGAAA	0.373													7	49					0	0	0	0	A	42679772	A	A	42679772	3	1	152	1	0	0	0	0	1	0	0	0	10502	942	33	2	2622	2	NKTR	3	42679772	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	32953467	42679772	155342658	13	27581											
STAB1	23166	broad.mit.edu	37	chr3	52544478	52544478	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgagctggacatgagaggTggctgccacaccgatgccct	8	8	14	11	1	0	2	0	2	0	1	0	5	0	3	3	3	3	2	3	3	0	0			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr3:52544478T>C	uc003dej.2	+	25	2816	c.2742T>C	c.(2740-2742)GGT>GGC	p.G914G		NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	914	Extracellular (Potential).|EGF-like 8.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ACATGAGAGGTGGCTGCCACA	0.647													16	33					0	0	0	0	C	52544478	C	C	52544478	2	2	152	1	0	0	0	0	0	0	0	1	15303	1683	59	5		5	STAB1	3	52544478	Silent	SNP	T	TCGA-CR-7385-01A-11D-2012-08	9864706	52544478	145477952	14	27582											
PEX5L	51555	broad.mit.edu	37	chr3	179525565	179525565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ataggcctccacggcttcctCgctgcggtctccgttcgcca	4	10	10	17	5	1	0	0	0	1	0	6	0	3	0	5	3	1	3	5	3	1	3			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr3:179525565C>T	uc003fki.1	-	14	1703	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K	PEX5L_uc011bqd.1_Missense_Mutation_p.E482K|PEX5L_uc011bqe.1_Missense_Mutation_p.E333K|PEX5L_uc011bqf.1_Missense_Mutation_p.E417K|PEX5L_uc003fkj.1_Missense_Mutation_p.E490K|PEX5L_uc010hxd.1_Missense_Mutation_p.E523K|PEX5L_uc011bqg.1_Missense_Mutation_p.E501K|PEX5L_uc011bqh.1_Missense_Mutation_p.E466K	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	525	TPR 4.				protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			ACGGCTTCCTCGCTGCGGTCT	0.537													28	227					0	0	0	0	T	179525565	T	T	179525565	3	4	152	1	0	0	0	0	1	0	0	0	11804	893	31	1	315	1	PEX5L	3	179525565	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	126981087	179525565	18496865	15	27583											
AMBN	258	broad.mit.edu	37	chr4	71467197	71467197	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagccatccttgaagcctcaAcagccaggactgaaaccttt	12	8	7	14	0	1	2	1	2	0	0	2	3	2	3	5	1	5	0	5	1	3	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr4:71467197A>G	uc003hfl.2	+	6	432	c.357A>G	c.(355-357)CAA>CAG	p.Q119Q		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	119					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			TGAAGCCTCAACAGCCAGGAC	0.502											OREG0016218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	146					0	0	0	0	G	71467197	G	G	71467197	2	3	152	1	0	0	0	0	0	0	0	1	563	40	2	5		5	AMBN	4	71467197	Silent	SNP	A	TCGA-CR-7385-01A-11D-2012-08		71467197	119687079	16	27584											
GPX8	493869	broad.mit.edu	37	chr5	54456872	54456872	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgccaactcacagacagaaaTtacttagggctgaaggaact	15	8	9	9	0	1	3	1	1	0	2	1	4	1	4	1	2	4	1	1	2	6	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr5:54456872T>G	uc003jpq.2	+	2	292	c.255T>G	c.(253-255)AAT>AAG	p.N85K	CDC20B_uc003jpn.1_Intron|CDC20B_uc010ivu.1_Intron|CDC20B_uc003jpo.1_Intron|CDC20B_uc010ivv.1_Intron|CDC20B_uc003jpp.2_Intron|GPX8_uc003jpr.2_Intron|GPX8_uc003jps.2_RNA|GPX8_uc003jpt.2_Missense_Mutation_p.N34K	NM_001008397	NP_001008398	Q8TED1	GPX8_HUMAN	glutathione peroxidase 8	85					response to oxidative stress	integral to membrane	glutathione peroxidase activity				0					Glutathione(DB00143)	CAGACAGAAATTACTTAGGGC	0.463													13	35					0	0	0	0	G	54456872	G	G	54456872	3	3	152	1	0	0	0	0	1	0	0	0	6785	1490	52	5	261	5	GPX8	5	54456872	Missense_Mutation	SNP	T	TCGA-CR-7385-01A-11D-2012-08		54456872	126458388	17	27585											
AP3B1	8546	broad.mit.edu	37	chr5	77590312	77590312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taaagaggccgaaggcccccGagggggaaatggttgaggtc	11	5	17	8	2	0	2	0	1	0	1	1	5	0	3	3	6	0	1	3	6	4	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr5:77590312G>A	uc003kfj.2	-	1	217	c.92C>T	c.(91-93)TCG>TTG	p.S31L		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	31					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		GAAGGCCCCCGAGGGGGAAAT	0.607									Hermansky-Pudlak_syndrome				12	73					0	0	0	0	A	77590312	A	A	77590312	3	1	152	1	0	0	0	0	1	0	0	0	744	1059	37	1	3300	1	AP3B1	5	77590312	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	23133440	77590312	103324948	18	27586											
BRD8	10902	broad.mit.edu	37	chr5	137500599	137500599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgactggctctggttctgcaGgttccaccttgatctctgca	5	14	10	12	0	3	2	0	2	3	0	5	2	4	2	2	3	2	5	2	3	0	3			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr5:137500599G>A	uc003lcf.1	-	12	1590	c.1535C>T	c.(1534-1536)CCT>CTT	p.P512L	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Missense_Mutation_p.P291L|BRD8_uc003lcg.2_Missense_Mutation_p.P585L|BRD8_uc003lci.2_Missense_Mutation_p.P515L|BRD8_uc003lch.2_Missense_Mutation_p.P406L|BRD8_uc011cym.1_Missense_Mutation_p.P496L|BRD8_uc010jer.1_Missense_Mutation_p.P481L|BRD8_uc011cyn.1_Missense_Mutation_p.P471L	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	512					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGGTTCTGCAGGTTCCACCTT	0.502													6	122					0	0	0	0	A	137500599	A	A	137500599	3	1	152	1	0	0	0	0	1	0	0	0	1511	1000	35	4	2300	4	BRD8	5	137500599	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	59910287	137500599	43414661	19	27587											
FAM53C	51307	broad.mit.edu	37	chr5	137680937	137680937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaatgtgccccagctcacaGaccctacagccctcctttct	8	10	5	18	0	3	1	2	0	1	1	4	1	4	1	5	0	4	1	5	0	2	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr5:137680937G>A	uc003lcv.2	+	4	1030	c.560G>A	c.(559-561)AGA>AAA	p.R187K	FAM53C_uc003lcw.2_Missense_Mutation_p.R187K|FAM53C_uc011cyq.1_Intron|FAM53C_uc011cyr.1_Intron	NM_001135647	NP_001129119	Q9NYF3	FA53C_HUMAN	hypothetical protein LOC51307	187										ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCAGCTCACAGACCCTACAGC	0.642													43	213					0	0	0	0	A	137680937	A	A	137680937	3	1	152	1	0	0	0	0	1	0	0	0	5613	942	33	2	570	2	FAM53C	5	137680937	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	180338	137680937	43234323	20	27588											
NSD1	64324	broad.mit.edu	37	chr5	176687121	176687121	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacccctaggcggggctgcCgaaatcatgagcatgttaat	10	10	11	10	2	1	1	1	1	0	0	1	2	1	1	3	3	3	3	3	3	4	3			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr5:176687121C>T	uc003mfr.3	+	14	5236	c.5098C>T	c.(5098-5100)CGA>TGA	p.R1700*	NSD1_uc003mft.3_Nonsense_Mutation_p.R1431*|NSD1_uc003mfs.1_Nonsense_Mutation_p.R1597*|NSD1_uc011dfx.1_Nonsense_Mutation_p.R1348*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1700					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GCGGGGCTGCCGAAATCATGA	0.433			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			5	59					0	0	0	0	T	176687121	T	T	176687121	4	4	152	1	0	0	0	0	0	1	0	0	10723	644	23	1	5148	1	NSD1	5	176687121	Nonsense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	39006184	176687121	4228139	21	27589											
HIST1H2AB	8335	broad.mit.edu	37	chr6	26033429	26033429	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcccttggccttatgatggCtctcagttttcttaggcagc	5	16	9	11	0	2	1	1	1	2	0	4	1	3	1	2	3	1	3	2	3	2	6			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:26033429C>G	uc003nft.1	-	1	368	c.368G>C	c.(367-369)AGC>ACC	p.S123T	HIST1H3B_uc003nfs.1_5'Flank	NM_003513	NP_003504	P04908	H2A1B_HUMAN	histone cluster 1, H2ab	123					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CTTATGATGGCTCTCAGTTTT	0.478													9	68					0	0	0	0	G	26033429	G	G	26033429	3	3	152	1	0	0	0	0	1	0	0	0	7168	797	28	4	28	4	HIST1H2AB	6	26033429	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08		26033429	145081638	22	27590											
ZNF76	7629	broad.mit.edu	37	chr6	35262305	35262305	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcttcgtcatcaacaggtgGcactgttggccacagccaac	9	9	9	14	1	3	0	2	0	1	0	4	0	3	0	2	3	3	2	2	3	2	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:35262305G>A	uc003oki.1	+	13	1772	c.1567G>A	c.(1567-1569)GCA>ACA	p.A523T	ZNF76_uc003okj.1_Missense_Mutation_p.A468T	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	523					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCAACAGGTGGCACTGTTGGC	0.517											OREG0017373	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	56					0	0	0	0	A	35262305	A	A	35262305	3	1	152	1	0	0	0	0	1	0	0	0	18202	1203	42	4	1613	4	ZNF76	6	35262305	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	9228876	35262305	135852762	23	27591											
PRPH2	5961	broad.mit.edu	37	chr6	42689524	42689524	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaggaaaagtccaggtaGcgattgctgatccactgaat	12	10	12	7	1	0	2	0	2	0	0	2	5	2	4	2	3	2	2	2	3	4	3			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:42689524G>A	uc003osk.2	-	1	835	c.549C>T	c.(547-549)CGC>CGT	p.R183R		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	183	Lumenal (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			AGTCCAGGTAGCGATTGCTGA	0.493													18	141					0	0	0	0	A	42689524	A	A	42689524	2	1	152	1	0	0	0	0	0	0	0	1	12639	958	34	4		4	PRPH2	6	42689524	Silent	SNP	G	TCGA-CR-7385-01A-11D-2012-08	7427219	42689524	128425543	24	27592											
TJAP1	93643	broad.mit.edu	37	chr6	43472753	43472753	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgatccagccagtcccccGgcccctggcagccccacccc	5	4	10	22	1	0	1	0	1	0	0	2	1	2	1	10	3	2	1	10	3	0	0			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:43472753G>A	uc003ovd.2	+	11	1210	c.834G>A	c.(832-834)CCG>CCA	p.P278P	TJAP1_uc003ovf.2_Silent_p.P268P|TJAP1_uc003ove.2_Silent_p.P268P|TJAP1_uc003ovc.2_Silent_p.P268P|TJAP1_uc010jyp.2_Silent_p.P237P|TJAP1_uc011dvh.1_Silent_p.P268P|TJAP1_uc003ovg.2_Silent_p.P144P|TJAP1_uc011dvi.1_Silent_p.P278P|TJAP1_uc011dvj.1_Silent_p.P78P|TJAP1_uc003ovi.2_Silent_p.P144P	NM_001146016	NP_001139488	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 isoform a	278	Pro-rich.					Golgi apparatus|tight junction	protein binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CCAGTCCCCCGGCCCCTGGCA	0.657													9	52					0	0	0	0	A	43472753	A	A	43472753	2	1	152	1	0	0	0	0	0	0	0	1	15994	1103	39	1		1	TJAP1	6	43472753	Silent	SNP	G	TCGA-CR-7385-01A-11D-2012-08	783229	43472753	127642314	25	27593											
ECT2L	345930	broad.mit.edu	37	chr6	139167812	139167812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcccggattcctgcgtatGaggtagagtatgttatgagg	9	12	13	7	2	0	3	0	2	0	1	2	4	2	4	2	3	1	4	2	3	4	5			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:139167812G>A	uc003qif.1	+	6	1004	c.901G>A	c.(901-903)GAG>AAG	p.E301K	ECT2L_uc011edq.1_Missense_Mutation_p.E232K	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	301					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TCCTGCGTATGAGGTAGAGTA	0.398													7	273					0	0	0	0	A	139167812	A	A	139167812	3	1	152	1	0	0	0	0	1	0	0	0	4924	1291	45	2	923	2	ECT2L	6	139167812	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	95695059	139167812	31947255	26	27594											
AKAP12	9590	broad.mit.edu	37	chr6	151670504	151670504	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagtggaagcttcagagaaGaaaaaggaacaagagccaga	20	3	13	5	0	1	4	1	0	0	4	1	8	1	6	1	2	3	1	1	2	7	1			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:151670504G>C	uc011eep.1	+	4	1218	c.978G>C	c.(976-978)AAG>AAC	p.K326N	AKAP12_uc003qoe.2_Missense_Mutation_p.K326N|AKAP12_uc003qof.2_Missense_Mutation_p.K228N|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.K221N	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	326	Involved in PKC-binding (Probable).				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CTTCAGAGAAGAAAAAGGAAC	0.507													10	45					0	0	0	0	C	151670504	C	C	151670504	3	2	152	1	0	0	0	0	1	0	0	0	448	933	33	2	1017	2	AKAP12	6	151670504	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	12502692	151670504	19444563	27	27595											
CYTH3	9265	broad.mit.edu	37	chr7	6226735	6226735	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggctatctgtttgttcctCtgagtcgttttgctattggt	4	20	10	7	1	2	1	0	1	2	0	4	1	3	1	1	2	1	5	1	2	2	7			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr7:6226735C>T	uc003spt.2	-	4	299	c.195G>A	c.(193-195)CAG>CAA	p.Q65Q		NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3	65					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						GTTTGTTCCTCTGAGTCGTTT	0.443													28	156					0	0	0	0	T	6226735	T	T	6226735	2	4	152	1	0	0	0	0	0	0	0	1	4222	912	32	2		2	CYTH3	7	6226735	Silent	SNP	C	TCGA-CR-7385-01A-11D-2012-08		6226735	152911928	28	27596											
LINGO2	158038	broad.mit.edu	37	chr9	27949880	27949880	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttaaaggcaaggaagggtaCagtagacagattggtgttgg	13	10	15	3	0	0	2	0	0	0	2	0	3	0	3	0	5	1	4	0	5	6	6	rs148104069		TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr9:27949880C>A	uc003zqu.1	-	2	984	c.790G>T	c.(790-792)GTA>TTA	p.V264L	LINGO2_uc010mjf.1_Missense_Mutation_p.V264L|LINGO2_uc003zqv.1_Missense_Mutation_p.V264L	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	264	LRR 9.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		AGGAAGGGTACAGTAGACAGA	0.463													26	124					1.74197e-06	2.07624e-05	1	0	A	27949880	A	A	27949880	3	1	152	1	0	0	0	0	1	0	0	0	8857	478	17	4	1034	4	LINGO2	9	27949880	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08		27949880	113263551	29	27597											
GOLM1	51280	broad.mit.edu	37	chr9	88650358	88650358	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgctcagggccctccatctCtggattttcctggctcactg	4	13	9	15	1	3	0	2	0	1	0	7	1	5	1	3	3	0	2	3	3	0	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr9:88650358C>G	uc004aol.2	-	8	1138	c.940G>C	c.(940-942)GAG>CAG	p.E314Q	GOLM1_uc004aom.2_Missense_Mutation_p.E314Q	NM_016548	NP_057632	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1	314	Lumenal (Potential).					Golgi apparatus|integral to plasma membrane					0						CCCTCCATCTCTGGATTTTCC	0.642											OREG0019278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	131					0	0	0	0	G	88650358	G	G	88650358	3	3	152	1	0	0	0	0	1	0	0	0	6604	922	32	2	277	2	GOLM1	9	88650358	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	60700478	88650358	52563073	30	27598											
ASTN2	23245	broad.mit.edu	37	chr9	119382714	119382714	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taggaactcatcagtgcactCttgaaggcctggacaaaaaa	15	8	9	9	0	3	1	2	1	1	0	3	3	3	3	1	3	2	1	1	3	6	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr9:119382714C>G	uc004bjs.1	-	18	3182	c.3081G>C	c.(3079-3081)AAG>AAC	p.K1027N	ASTN2_uc004bjr.1_Missense_Mutation_p.K1023N|ASTN2_uc004bjt.1_Missense_Mutation_p.K976N|ASTN2_uc004bjp.1_Missense_Mutation_p.K120N|ASTN2_uc004bjq.1_Missense_Mutation_p.K79N|ASTN2_uc011lxr.1_Missense_Mutation_p.K79N|ASTN2_uc011lxs.1_Missense_Mutation_p.K79N|ASTN2_uc011lxt.1_Missense_Mutation_p.K79N|ASTN2_uc004bjv.1_Missense_Mutation_p.K79N	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1027	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TCAGTGCACTCTTGAAGGCCT	0.507													34	150					0	0	0	0	G	119382714	G	G	119382714	3	3	152	1	0	0	0	0	1	0	0	0	1067	912	32	2	1081	2	ASTN2	9	119382714	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	30732356	119382714	21830717	31	27599											
CYP2C9	1559	broad.mit.edu	37	chr10	96708979	96708979	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaagtaaaagaacaccaaGaatcaatggacatgaacaac	24	4	6	7	0	1	3	1	1	0	2	1	4	1	4	1	1	3	1	1	1	10	1			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr10:96708979G>A	uc001kka.3	+	5	782	c.757G>A	c.(757-759)GAA>AAA	p.E253K	CYP2C9_uc009xut.2_Missense_Mutation_p.E253K	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	253					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	AGAACACCAAGAATCAATGGA	0.333													6	45					0	0	0	0	A	96708979	A	A	96708979	3	1	152	1	0	0	0	0	1	0	0	0	4185	943	33	2	775	2	CYP2C9	10	96708979	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08		96708979	38825768	32	27600											
OR51L1	119682	broad.mit.edu	37	chr11	5021081	5021081	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttcttcccccagtccttaAccctattgtctatagtgtca	7	16	4	14	0	4	0	1	0	3	0	6	0	6	0	4	0	1	0	4	0	4	7			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr11:5021081A>G	uc010qyu.1	+	1	869	c.869A>G	c.(868-870)AAC>AGC	p.N290S		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCAGTCCTTAACCCTATTGTC	0.458													5	43					0	0	0	0	G	5021081	G	G	5021081	3	3	152	1	0	0	0	0	1	0	0	0	11156	43	2	5	871	5	OR51L1	11	5021081	Missense_Mutation	SNP	A	TCGA-CR-7385-01A-11D-2012-08		5021081	129985435	33	27601											
UEVLD	55293	broad.mit.edu	37	chr11	18557990	18557992	+	In_Frame_Del	DEL	CTT	-	-																															ttgagaggtatgactcactaCttcttcttggccactccatg																										TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr11:18557990_18557992delCTT	uc001mot.2	-	10	1165_1167	c.1085_1087delAAG	c.(1084-1089)GAAGTA>GTA	p.E362del	UEVLD_uc001mou.2_In_Frame_Del_p.E362del|UEVLD_uc010rde.1_In_Frame_Del_p.E232del|UEVLD_uc010rdf.1_In_Frame_Del_p.E340del|UEVLD_uc010rdg.1_In_Frame_Del_p.E232del|UEVLD_uc001mov.2_In_Frame_Del_p.E340del	NM_001040697	NP_001035787	Q8IX04	UEVLD_HUMAN	ubiquitin-conjugating enzyme E2-like isoform a	362					cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor				0						TGACTCACTACTTCTTCTTGGCC	0.374													---	---	---								-	18557992	-	-	18557990	7	5	152	1	0	1	0	1	0	0	0	0	17001	565	20	0	340	0	UEVLD	11	18557990	In_Frame_Del	DEL	CTT	TCGA-CR-7385-01A-11D-2012-08	13536909	18557990	116448526	34	27602											
ODZ4	26011	broad.mit.edu	37	chr11	78413296	78413296	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	accttgcttagcaggaagtgGtcaatgccagggacctggca	10	8	13	10	0	1	0	1	0	0	0	1	2	1	2	3	4	3	3	3	4	3	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr11:78413296G>A	uc001ozl.3	-	28	4825	c.4362C>T	c.(4360-4362)GAC>GAT	p.D1454D	ODZ4_uc009yvb.1_Silent_p.D38D	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1454	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GCAGGAAGTGGTCAATGCCAG	0.547													9	41					0	0	0	0	A	78413296	A	A	78413296	2	1	152	1	0	0	0	0	0	0	0	1	10891	1252	44	4		4	ODZ4	11	78413296	Silent	SNP	G	TCGA-CR-7385-01A-11D-2012-08	59855306	78413296	56593220	35	27603											
CCDC89	220388	broad.mit.edu	37	chr11	85396815	85396815	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagcgttcctctagtttcCgactgtactcaccctgggcc	7	12	8	14	2	2	0	1	0	1	0	4	1	4	0	4	1	2	3	4	1	4	5			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr11:85396815C>T	uc001pau.1	-	1	506	c.359G>A	c.(358-360)CGG>CAG	p.R120Q		NM_152723	NP_689936	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	120	Potential.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CTCTAGTTTCCGACTGTACTC	0.542													6	103					0	0	0	0	T	85396815	T	T	85396815	3	4	152	1	0	0	0	0	1	0	0	0	2879	652	23	1	769	1	CCDC89	11	85396815	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	6983519	85396815	49609701	36	27604											
CWF19L2	143884	broad.mit.edu	37	chr11	107224441	107224441	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcatccagggtgtaatagtCtccatctgtttttcccataa	9	15	7	10	0	3	0	1	0	2	0	6	0	5	0	3	1	0	2	3	1	3	5			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr11:107224441C>G	uc010rvp.1	-	13	1924	c.1894G>C	c.(1894-1896)GAC>CAC	p.D632H	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_Intron	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	632							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		GTGTAATAGTCTCCATCTGTT	0.388													14	75					0	0	0	0	G	107224441	G	G	107224441	3	3	152	1	0	0	0	0	1	0	0	0	4089	913	32	2	814	2	CWF19L2	11	107224441	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	21827626	107224441	27782075	37	27605											
A2ML1	144568	broad.mit.edu	37	chr12	9027036	9027036	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagctcattaagaacactCagacttacaccttcaccatc	14	9	3	15	0	3	2	3	0	0	2	4	2	3	2	2	0	3	1	2	0	3	3			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr12:9027036C>G	uc001quz.3	+	34	4335	c.4237C>G	c.(4237-4239)CAG>GAG	p.Q1413E	A2ML1_uc001qva.1_Missense_Mutation_p.Q993E|A2ML1_uc010sgm.1_Missense_Mutation_p.Q913E|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1257						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						TAAGAACACTCAGACTTACAC	0.433													18	54					0	0	0	0	G	9027036	G	G	9027036	3	3	152	1	0	0	0	0	1	0	0	0	5	827	29	2	4371	2	A2ML1	12	9027036	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08		9027036	124824859	38	27606											
TM7SF3	51768	broad.mit.edu	37	chr12	27149786	27149786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actccaaattacagcctccaGggacaggatctggataagaa	15	7	9	10	0	1	1	0	0	1	1	3	4	3	4	3	3	2	0	3	3	4	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr12:27149786G>A	uc010sjl.1	-	4	645	c.407C>T	c.(406-408)CCT>CTT	p.P136L		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	136						integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					ACAGCCTCCAGGGACAGGATC	0.353													4	22					0	0	0	0	A	27149786	A	A	27149786	3	1	152	1	0	0	0	0	1	0	0	0	16041	1000	35	4	1341	4	TM7SF3	12	27149786	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	18122750	27149786	106702109	39	27607											
MDM1	56890	broad.mit.edu	37	chr12	68724993	68724993	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaagttcctctggtattcActcagcccctgtaatgcaaa	11	11	8	11	0	3	0	2	0	1	0	4	1	4	1	3	2	2	4	3	2	4	4			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr12:68724993A>G	uc001stz.2	-	2	163	c.27T>C	c.(25-27)AGT>AGC	p.S9S	MDM1_uc010stc.1_Silent_p.S9S|MDM1_uc009zqv.1_5'UTR|MDM1_uc001sua.3_Silent_p.S9S|MDM1_uc010std.1_Silent_p.S9S	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	9						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		TCTGGTATTCACTCAGCCCCT	0.418													9	161					0	0	0	0	G	68724993	G	G	68724993	2	3	152	1	0	0	0	0	0	0	0	1	9465	156	6	5		5	MDM1	12	68724993	Silent	SNP	A	TCGA-CR-7385-01A-11D-2012-08	41575207	68724993	65126902	40	27608											
NAV3	89795	broad.mit.edu	37	chr12	78400292	78400292	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctgcctctgccatcccttCtccaagtgccagcaagccct	6	10	6	19	0	2	0	0	0	2	0	5	0	4	0	7	0	5	1	7	0	2	1			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr12:78400292C>T	uc001syp.2	+	8	1147	c.974C>T	c.(973-975)TCT>TTT	p.S325F	NAV3_uc001syo.2_Missense_Mutation_p.S325F	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	325						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GCCATCCCTTCTCCAAGTGCC	0.547										HNSCC(70;0.22)			14	65					0	0	0	0	T	78400292	T	T	78400292	3	4	152	1	0	0	0	0	1	0	0	0	10238	913	32	2	1004	2	NAV3	12	78400292	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	9675299	78400292	55451603	41	27609											
STYX	6815	broad.mit.edu	37	chr14	53223283	53223283	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagatatttagtcctggAtattgcagataatccagttg	11	16	8	6	0	1	2	1	0	0	2	3	3	3	3	2	1	1	2	2	1	4	8			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr14:53223283A>T	uc010tqy.1	+	6	319	c.257A>T	c.(256-258)GAT>GTT	p.D86V	STYX_uc001xaa.2_Missense_Mutation_p.D86V	NM_001130701	NP_001124173	Q8WUJ0	STYX_HUMAN	serine/threonine/tyrosine interacting protein	86					protein dephosphorylation|spermatogenesis	cytoplasm	protein tyrosine/serine/threonine phosphatase activity				0	Breast(41;0.176)					TTAGTCCTGGATATTGCAGAT	0.244													8	49					0	0	0	0	T	53223283	T	T	53223283	3	4	152	1	0	0	0	0	1	0	0	0	15426	333	12	5	275	5	STYX	14	53223283	Missense_Mutation	SNP	A	TCGA-CR-7385-01A-11D-2012-08		53223283	54126257	42	27610											
MAPKBP1	23005	broad.mit.edu	37	chr15	42111558	42111558	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcactgcccgtccttgccaaGagtaccaagaaggcactggg	10	6	12	13	1	0	2	0	0	0	2	1	2	1	2	4	2	3	3	4	2	4	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr15:42111558G>A	uc001zok.3	+	22	2710	c.2424G>A	c.(2422-2424)AAG>AAA	p.K808K	MAPKBP1_uc001zoj.3_Silent_p.K802K|MAPKBP1_uc010bcj.2_Silent_p.K309K|MAPKBP1_uc010bci.2_Silent_p.K802K|MAPKBP1_uc010udb.1_Silent_p.K641K|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Silent_p.K309K	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	808										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TCCTTGCCAAGAGTACCAAGA	0.542													13	116					0	0	0	0	A	42111558	A	A	42111558	2	1	152	1	0	0	0	0	0	0	0	1	9345	933	33	2		2	MAPKBP1	15	42111558	Silent	SNP	G	TCGA-CR-7385-01A-11D-2012-08		42111558	60419834	43	27611											
LRRC57	255252	broad.mit.edu	37	chr15	42839505	42839505	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacttgcagctctcccactGagtcaggtatacttcgaatc	9	12	8	12	1	2	2	1	2	1	0	5	3	2	2	1	1	3	3	1	1	3	4			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr15:42839505G>A	uc001zqd.1	-	3	814	c.446C>T	c.(445-447)TCA>TTA	p.S149L	HAUS2_uc001zqe.2_5'Flank|HAUS2_uc010udi.1_5'Flank|HAUS2_uc001zqf.2_5'Flank|LRRC57_uc001zqc.2_Missense_Mutation_p.S149L	NM_153260	NP_694992	Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	149	LRR 5.										0		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		CTCTCCCACTGAGTCAGGTAT	0.468													7	84					0	0	0	0	A	42839505	A	A	42839505	3	1	152	1	0	0	0	0	1	0	0	0	9063	1294	45	2	285	2	LRRC57	15	42839505	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	727947	42839505	59691887	44	27612											
ZNF592	9640	broad.mit.edu	37	chr15	85341886	85341886	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcttcagcggacacatcctCaagccgccctggctctcgag	7	8	10	16	3	4	0	2	0	2	0	6	2	5	1	3	2	2	1	3	2	1	1			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr15:85341886C>G	uc002bld.2	+	8	3140	c.2804C>G	c.(2803-2805)TCA>TGA	p.S935*	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	935					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GACACATCCTCAAGCCGCCCT	0.632													9	50					0	0	0	0	G	85341886	G	G	85341886	4	3	152	1	0	0	0	0	0	1	0	0	18089	838	29	2	2822	2	ZNF592	15	85341886	Nonsense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	42502381	85341886	17189506	45	27613											
SEZ6L2	26470	broad.mit.edu	37	chr16	29888272	29888272	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtgtcgttcctcgggacctCtgcaggggagggaaggcgag	6	7	18	10	4	1	0	0	0	1	0	4	4	2	3	2	5	1	2	2	5	1	1			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr16:29888272C>T	uc002duq.3	-	12	2150	c.1910_splice	c.e12-1	p.E637_splice	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Splice_Site_p.E567_splice|SEZ6L2_uc002dur.3_Splice_Site_p.E567_splice|SEZ6L2_uc002dus.3_Splice_Site_p.E523_splice|SEZ6L2_uc010vec.1_Splice_Site_p.E637_splice|SEZ6L2_uc010ved.1_Splice_Site_p.E593_splice	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform							endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CTCGGGACCTCTGCAGGGGAG	0.652													3	18					0	0	0	0	T	29888272	T	T	29888272	5	4	152	1	0	0	0	0	0	0	1	0	14209	927	32	2	890	2	SEZ6L2	16	29888272	Splice_Site	SNP	C	TCGA-CR-7385-01A-11D-2012-08		29888272	60466481	46	27614											
MYST1	84148	broad.mit.edu	37	chr16	31138398	31138398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccacagcagccttggagaagGagcatgaggcggtaagtggg	11	5	17	8	1	0	2	0	1	0	1	0	4	0	3	2	5	3	3	2	5	2	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr16:31138398G>A	uc002eay.2	+	4	523	c.505G>A	c.(505-507)GAG>AAG	p.E169K	MYST1_uc002eax.2_Missense_Mutation_p.E169K|MYST1_uc002eaz.2_Missense_Mutation_p.E11K|MYST1_uc002eba.2_5'Flank|MYST1_uc002ebb.2_5'Flank	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	169					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1						CTTGGAGAAGGAGCATGAGGC	0.622													13	47					0	0	0	0	A	31138398	A	A	31138398	3	1	152	1	0	0	0	0	1	0	0	0	10155	1175	41	2	519	2	MYST1	16	31138398	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	1250126	31138398	59216355	47	27615											
NMT1	4836	broad.mit.edu	37	chr17	43175832	43175832	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgctccagttctgatccgaGagatcaccaggcgggttcac	8	10	11	12	2	3	2	2	1	1	1	5	4	5	2	3	2	1	3	3	2	0	3			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr17:43175832G>C	uc002ihz.2	+	7	814	c.796G>C	c.(796-798)GAG>CAG	p.E266Q	NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	266					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				TCTGATCCGAGAGATCACCAG	0.522													4	127					0	0	0	0	C	43175832	C	C	43175832	3	2	152	1	0	0	0	0	1	0	0	0	10557	943	33	2	822	2	NMT1	17	43175832	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08		43175832	38019378	48	27616											
NDUFS7	374291	broad.mit.edu	37	chr19	1387822	1387822	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcagctcctggcctgcGcggcttccggatccttggtc	2	11	12	16	3	1	0	0	0	1	0	5	1	4	1	4	4	3	3	4	4	0	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr19:1387822G>A	uc002lse.3	+	2	72	c.29G>A	c.(28-30)CGC>CAC	p.R10H	NDUFS7_uc002lsf.2_Missense_Mutation_p.R74H|NDUFS7_uc002lsh.2_Missense_Mutation_p.R74H|NDUFS7_uc002lsg.2_5'UTR	NM_024407	NP_077718	O75251	NDUS7_HUMAN	NADH-ubiquinone oxidoreductase Fe-S protein 7	10					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)|Breast(49;0.00186)|Lung NSC(49;0.00292)|all_lung(49;0.00419)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	NADH(DB00157)	CCTGGCCTGCGCGGCTTCCGG	0.711													9	41					0	0	0	0	A	1387822	A	A	1387822	3	1	152	1	0	0	0	0	1	0	0	0	10351	1087	38	1	35	1	NDUFS7	19	1387822	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08		1387822	57741161	49	27617											
ATP8B3	148229	broad.mit.edu	37	chr19	1802615	1802615	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccccacgaagtggtgcatccGactgttaggcgcctcacacg	8	7	11	15	4	1	0	1	0	0	0	2	2	2	0	4	2	1	2	4	2	2	1			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr19:1802615G>A	uc002ltw.2	-	11	1168	c.934C>T	c.(934-936)CGG>TGG	p.R312W	ATP8B3_uc002ltv.2_Missense_Mutation_p.R259W|ATP8B3_uc002ltx.2_RNA|ATP8B3_uc002lty.1_Missense_Mutation_p.R60W|ATP8B3_uc002ltz.1_Missense_Mutation_p.R259W	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	312	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGTGCATCCGACTGTTAGGC	0.612													7	20					0	0	0	0	A	1802615	A	A	1802615	3	1	152	1	0	0	0	0	1	0	0	0	1198	1057	37	1	3092	1	ATP8B3	19	1802615	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	414793	1802615	57326368	50	27618											
FBN3	84467	broad.mit.edu	37	chr19	8152087	8152087	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgctgaccatctgcacactCgtccacatcttcggatgacc	8	10	7	16	2	2	2	0	2	2	0	5	3	3	3	3	1	2	2	3	1	0	1			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr19:8152087C>T	uc002mjf.2	-	53	6649	c.6628G>A	c.(6628-6630)GAG>AAG	p.E2210K	FBN3_uc002mje.2_Missense_Mutation_p.E49K	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2210	EGF-like 36; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TCTGCACACTCGTCCACATCT	0.632													6	54					0	0	0	0	T	8152087	T	T	8152087	3	4	152	1	0	0	0	0	1	0	0	0	5736	893	31	1	1845	1	FBN3	19	8152087	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	6349472	8152087	50976896	51	27619											
SLC44A2	57153	broad.mit.edu	37	chr19	10742817	10742817	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatgatcatcatggtgattCtggtgctgggctacggtgcg	6	13	15	7	2	3	3	2	3	1	0	3	3	3	3	0	4	3	2	0	4	1	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr19:10742817C>T	uc002mpf.2	+	10	947	c.808C>T	c.(808-810)CTG>TTG	p.L270L	SLC44A2_uc002mpe.3_Silent_p.L268L|SLC44A2_uc002mpg.1_5'Flank	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	270	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	CATGGTGATTCTGGTGCTGGG	0.562													5	131					0	0	0	0	T	10742817	T	T	10742817	2	4	152	1	0	0	0	0	0	0	0	1	14700	912	32	2		2	SLC44A2	19	10742817	Silent	SNP	C	TCGA-CR-7385-01A-11D-2012-08	2590730	10742817	48386166	52	27620											
LILRB2	10288	broad.mit.edu	37	chr19	54782209	54782209	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtaggtccccgcgtgggctGaggtcacaggactcatgggg	6	8	17	10	2	2	1	2	1	0	0	3	2	3	2	2	6	0	2	2	6	1	1			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr19:54782209G>C	uc002qfb.2	-	7	1429	c.1163C>G	c.(1162-1164)TCA>TGA	p.S388*	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Nonsense_Mutation_p.S388*|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Nonsense_Mutation_p.S388*|LILRB2_uc010yet.1_Nonsense_Mutation_p.S272*|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	388	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CGCGTGGGCTGAGGTCACAGG	0.592													4	158					0	0	0	0	C	54782209	C	C	54782209	4	2	152	1	0	0	0	0	0	1	0	0	8832	1294	45	2	665	2	LILRB2	19	54782209	Nonsense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08	44039392	54782209	4346774	53	27621											
DIP2A	23181	broad.mit.edu	37	chr21	47959793	47959793	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgttgctctgtgcagggtCgatctcctcctgtgacgcct	3	14	11	13	2	2	1	0	1	2	0	5	2	3	1	3	1	2	3	3	1	0	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr21:47959793C>T	uc002zjo.2	+	17	2108	c.1925C>T	c.(1924-1926)TCG>TTG	p.S642L	DIP2A_uc011afy.1_Missense_Mutation_p.S578L|DIP2A_uc011afz.1_Missense_Mutation_p.S638L|DIP2A_uc002zjl.2_Missense_Mutation_p.S642L|DIP2A_uc002zjm.2_Missense_Mutation_p.S642L|DIP2A_uc010gql.2_Missense_Mutation_p.S599L|DIP2A_uc002zjn.2_Missense_Mutation_p.S642L|DIP2A_uc002zjp.1_Missense_Mutation_p.S387L|DIP2A_uc002zjq.2_Missense_Mutation_p.S34L	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	642					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		TGTGCAGGGTCGATCTCCTCC	0.597													33	72					0	0	0	0	T	47959793	T	T	47959793	3	4	152	1	0	0	0	0	1	0	0	0	4549	893	31	1	1991	1	DIP2A	21	47959793	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08		47959793	170102	54	27622											
BCOR	54880	broad.mit.edu	37	chrX	39923017	39923017	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacttccttcctgctttgccGgccaggtttgccatctgctg	3	14	9	15	1	1	0	0	0	1	0	3	0	3	0	5	2	4	3	5	2	0	4	rs147934033		TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chrX:39923017G>A	uc004den.3	-	8	3983	c.3691C>T	c.(3691-3693)CGG>TGG	p.R1231W	BCOR_uc004dep.3_Missense_Mutation_p.R1197W|BCOR_uc004deo.3_Missense_Mutation_p.R1179W|BCOR_uc010nhb.2_5'Flank|BCOR_uc004dem.3_Missense_Mutation_p.R1197W	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1231					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CTGCTTTGCCGGCCAGGTTTG	0.547													4	83					0	0	0	0	A	39923017	A	A	39923017	3	1	152	1	0	0	0	0	1	0	0	0	1388	1115	39	1	1608	1	BCOR	23	39923017	Missense_Mutation	SNP	G	TCGA-CR-7385-01A-11D-2012-08		39923017	115347543	55	27623											
AWAT1	158833	broad.mit.edu	37	chrX	69458123	69458123	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agccatggcactggcaacctCgtgggcattgtagtgggagg	8	8	16	9	1	0	0	0	0	0	0	1	1	0	1	2	5	2	4	2	5	2	2			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chrX:69458123C>T	uc004dxy.2	+	5	563	c.522C>T	c.(520-522)CTC>CTT	p.L174L		NM_001013579	NP_001013597	Q58HT5	AWAT1_HUMAN	wax synthase 1	174					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			ovary(3)	3						CTGGCAACCTCGTGGGCATTG	0.572													10	31					0	0	0	0	T	69458123	T	T	69458123	2	4	152	1	0	0	0	0	0	0	0	1	1236	871	31	1		1	AWAT1	23	69458123	Silent	SNP	C	TCGA-CR-7385-01A-11D-2012-08	29535106	69458123	85812437	56	27624											
SPANXE	171489	broad.mit.edu	37	chrX	140786496	140786496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctaacagtcttaccatctCgttggcctcgttggaatcac	9	12	7	13	2	3	0	1	0	2	0	5	1	3	1	3	2	2	2	3	2	3	4			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chrX:140786496C>T	uc004fbq.2	-	1	160	c.67G>A	c.(67-69)GAG>AAG	p.E23K		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	SPANX family, member E	23						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					CTTACCATCTCGTTGGCCTCG	0.299													26	43					0	0	0	0	T	140786496	T	T	140786496	3	4	152	1	0	0	0	0	1	0	0	0	15055	893	31	1	234	1	SPANXE	23	140786496	Missense_Mutation	SNP	C	TCGA-CR-7385-01A-11D-2012-08	71328373	140786496	14484064	57	27625											
DNAJC11	55735	broad.mit.edu	37	chr1	6738499	6738499	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcttcccatatatatcataGatggccctggtttgggggtc	7	14	10	10	0	2	1	1	0	1	1	4	1	3	1	2	4	0	1	2	4	4	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:6738499G>A	uc001aof.2	-	3	337	c.231C>T	c.(229-231)ATC>ATT	p.I77I	DNAJC11_uc010nzt.1_Silent_p.I39I|DNAJC11_uc001aog.2_Silent_p.I77I|DNAJC11_uc010nzu.1_Intron	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	77	J.				protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		ATATATCATAGATGGCCCTGG	0.388													11	48					0	0	0	0	A	6738499	A	A	6738499	2	1	153	1	0	0	0	0	0	0	0	1	4652	932	33	2		2	DNAJC11	1	6738499	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08		6738499	242512122	1	27626											
SLC2A7	155184	broad.mit.edu	37	chr1	9067373	9067373	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgtgcaggtactcactgggCccaatggaatgtcccgcgat	8	8	13	12	3	1	0	1	0	0	0	2	2	2	1	2	3	2	2	2	3	3	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:9067373C>T	uc009vmo.1	-	10	1188	c.1188G>A	c.(1186-1188)GGG>GGA	p.G396G		NM_207420	NP_997303	Q6PXP3	GTR7_HUMAN	intestinal facilitative glucose transporter 7	396	Helical; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity				0	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		ACTCACTGGGCCCAATGGAAT	0.433													4	53					0	0	0	0	T	9067373	T	T	9067373	2	4	153	1	0	0	0	0	0	0	0	1	14614	726	26	4		4	SLC2A7	1	9067373	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	2328874	9067373	240183248	2	27627											
ZBTB17	7709	broad.mit.edu	37	chr1	16273491	16273491	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccggctcagcaagtgacttGagggcatggcaggccgtgat	8	7	16	10	2	1	3	1	3	0	0	1	3	1	3	2	4	1	4	2	4	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:16273491G>C	uc001axl.3	-	4	572	c.333C>G	c.(331-333)CTC>CTG	p.L111L	ZBTB17_uc010obq.1_Nonsense_Mutation_p.S21*|ZBTB17_uc010obr.1_Silent_p.L111L|ZBTB17_uc010obs.1_Silent_p.L35L|ZBTB17_uc010obt.1_Intron|ZBTB17_uc010obu.1_Silent_p.L35L|ZBTB17_uc009vom.1_Intron|ZBTB17_uc010obv.1_Silent_p.L111L	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	111					negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		CAAGTGACTTGAGGGCATGGC	0.602													8	45					0	0	0	0	C	16273491	C	C	16273491	2	2	153	1	0	0	0	0	0	0	0	1	17594	1277	45	2		2	ZBTB17	1	16273491	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	7206118	16273491	232977130	3	27628											
HSPG2	3339	broad.mit.edu	37	chr1	22170783	22170783	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgatgcggatgggtggggctCcacctggggctggggcacag	5	6	20	10	2	0	0	0	0	0	0	1	2	1	1	2	8	1	3	2	8	0	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:22170783C>T	uc001bfj.2	-	65	8514	c.8474G>A	c.(8473-8475)GGA>GAA	p.G2825E	HSPG2_uc009vqd.2_Missense_Mutation_p.G2826E	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2825	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGGTGGGGCTCCACCTGGGGC	0.682													10	67					0	0	0	0	T	22170783	T	T	22170783	3	4	153	1	0	0	0	0	1	0	0	0	7469	855	30	2	4833	2	HSPG2	1	22170783	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	5897292	22170783	227079838	4	27629											
XKR8	55113	broad.mit.edu	37	chr1	28293631	28293631	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggggtatcagctgcctCagaacaggcgcatgacccat	11	6	12	12	1	2	3	2	1	0	2	2	3	2	3	2	3	3	3	2	3	2	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:28293631C>A	uc001bph.1	+	3	1185	c.1108C>A	c.(1108-1110)CAG>AAG	p.Q370K		NM_018053	NP_060523	Q9H6D3	XKR8_HUMAN	XK, Kell blood group complex subunit-related	370						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;4.72e-24)|Colorectal(126;1.52e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00572)|READ - Rectum adenocarcinoma(331;0.0526)		TCAGCTGCCTCAGAACAGGCG	0.577													10	71					9.70103e-10	1.05692e-09	1	0	A	28293631	A	A	28293631	3	1	153	1	0	0	0	0	1	0	0	0	17505	827	29	2	1118	2	XKR8	1	28293631	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	6122848	28293631	220956990	5	27630											
COL16A1	1307	broad.mit.edu	37	chr1	32165443	32165443	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtcacgggggccgccccCaggcgcaggatgagaggccc	6	3	18	14	3	1	1	1	1	0	1	1	3	1	2	4	6	0	1	4	6	0	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:32165443C>T	uc001btk.1	-	4	602	c.237G>A	c.(235-237)CTG>CTA	p.L79L	COL16A1_uc001btj.1_5'Flank|COL16A1_uc001btl.3_Silent_p.L79L	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	79	TSP N-terminal.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGCCGCCCCCAGGCGCAGGA	0.592													14	83					0	0	0	0	T	32165443	T	T	32165443	2	4	153	1	0	0	0	0	0	0	0	1	3688	581	21	4		4	COL16A1	1	32165443	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	3871812	32165443	217085178	6	27631											
INPP5B	3633	broad.mit.edu	37	chr1	38345771	38345771	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctacctggtatcccagtcGtcagagcccgtatcatactt	9	11	7	14	2	2	1	2	0	0	1	4	1	3	1	4	1	3	2	4	1	4	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:38345771G>A	uc001ccg.1	-	15	1621	c.1527C>T	c.(1525-1527)GAC>GAT	p.D509D	INPP5B_uc009vvk.1_Silent_p.D450D|INPP5B_uc001ccf.1_Silent_p.D345D|INPP5B_uc010oij.1_RNA	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	589				GSDDWDTSEKCRAPAWCDRI -> RALTTGIPVRSAVLLPG VIGF (in Ref. 5; AA sequence).	regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TATCCCAGTCGTCAGAGCCCG	0.478													19	78					0	0	0	0	A	38345771	A	A	38345771	2	1	153	1	0	0	0	0	0	0	0	1	7794	1136	40	1		1	INPP5B	1	38345771	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	6180328	38345771	210904850	7	27632											
IPO13	9670	broad.mit.edu	37	chr1	44422118	44422118	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcatcgctgtggccctgggCgagaaccactcccggtaaag	8	6	13	14	4	0	1	0	0	0	1	2	2	1	1	3	3	1	3	3	3	3	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:44422118C>T	uc001ckx.2	+	3	1743	c.948C>T	c.(946-948)GGC>GGT	p.G316G		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	316					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TGGCCCTGGGCGAGAACCACT	0.597													16	52					0	0	0	0	T	44422118	T	T	44422118	2	4	153	1	0	0	0	0	0	0	0	1	7833	755	27	1		1	IPO13	1	44422118	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	6076347	44422118	204828503	8	27633											
UROD	7389	broad.mit.edu	37	chr1	45480410	45480410	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatctgcttttttctagatCatctttgctaaggatgggca	9	16	9	7	0	4	2	1	0	3	2	4	3	4	3	0	2	2	3	0	2	2	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:45480410C>A	uc001cna.1	+	8	885	c.777C>A	c.(775-777)ATC>ATA	p.I259I	UROD_uc001cnb.1_Silent_p.I224I|UROD_uc010olj.1_3'UTR|UROD_uc001cnc.1_Silent_p.I164I	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	259						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					TTTTCTAGATCATCTTTGCTA	0.527									Porphyria_Cutanea_Tarda_Type_II		OREG0013449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	33					0.00909568	0.00943256	1	0	A	45480410	A	A	45480410	2	1	153	1	0	0	0	0	0	0	0	1	17097	816	29	2		2	UROD	1	45480410	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	1058292	45480410	203770211	9	27634											
MUTYH	4595	broad.mit.edu	37	chr1	45797203	45797203	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggctcccaggtcacggacggGaactcccacagtcctgccag	8	5	12	16	2	1	0	1	0	0	0	4	2	4	2	4	4	2	1	4	4	1	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:45797203G>A	uc001cnm.2	-	13	1419	c.1203C>T	c.(1201-1203)TTC>TTT	p.F401F	MUTYH_uc009vxn.2_Silent_p.F226F|MUTYH_uc001cnf.2_Silent_p.F376F|MUTYH_uc009vxo.2_Silent_p.F376F|MUTYH_uc001cng.2_Silent_p.F387F|MUTYH_uc001cnj.2_Silent_p.F284F|MUTYH_uc001cni.2_Silent_p.F376F|MUTYH_uc001cnh.2_Silent_p.F377F|MUTYH_uc001cno.2_Silent_p.F284F|MUTYH_uc001cnk.2_Silent_p.F261F|MUTYH_uc010oll.1_Silent_p.F85F|MUTYH_uc001cnl.2_Silent_p.F390F|MUTYH_uc009vxp.2_Silent_p.F404F|MUTYH_uc001cnn.2_Silent_p.F391F	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	401	Nudix hydrolase.				depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					TCACGGACGGGAACTCCCACA	0.657			Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				15	56					0	0	0	0	A	45797203	A	A	45797203	2	1	153	1	0	0	0	0	0	0	0	1	10046	1165	41	2		2	MUTYH	1	45797203	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	316793	45797203	203453418	10	27635											
TACSTD2	4070	broad.mit.edu	37	chr1	59042150	59042150	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgcccttgatgtccctctCgaagtagtaggcggcatcgc	6	10	11	14	4	1	1	0	1	1	0	5	2	2	1	2	2	0	3	2	2	3	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:59042150C>T	uc001cyz.3	-	1	1017	c.679G>A	c.(679-681)GAG>AAG	p.E227K		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	227	Extracellular (Potential).				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					ATGTCCCTCTCGAAGTAGTAG	0.632													4	20					0	0	0	0	T	59042150	T	T	59042150	3	4	153	1	0	0	0	0	1	0	0	0	15574	893	31	1	296	1	TACSTD2	1	59042150	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	13244947	59042150	190208471	11	27636											
KIAA1324	57535	broad.mit.edu	37	chr1	109714534	109714534	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acatcgcctccaacacggacGaatgcacagccacactgatg	13	5	8	15	3	0	1	0	1	0	0	2	3	1	2	3	1	3	1	3	1	2	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:109714534G>A	uc001dwq.2	+	5	650	c.514G>A	c.(514-516)GAA>AAA	p.E172K	KIAA1324_uc009wex.1_Missense_Mutation_p.E172K|KIAA1324_uc009wey.2_Missense_Mutation_p.E172K|KIAA1324_uc010ovg.1_Missense_Mutation_p.E70K	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	172	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CAACACGGACGAATGCACAGC	0.532													17	71					0	0	0	0	A	109714534	A	A	109714534	3	1	153	1	0	0	0	0	1	0	0	0	8262	1059	37	1	528	1	KIAA1324	1	109714534	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	50672384	109714534	139536087	12	27637											
CELSR2	1952	broad.mit.edu	37	chr1	109815344	109815344	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcctggaaggtcaagaccagCagcatggtgaggacagaacg	13	5	14	9	1	1	3	1	1	0	2	2	5	2	5	2	4	3	2	2	4	3	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:109815344C>A	uc001dxa.3	+	30	8198	c.8137C>A	c.(8137-8139)CAG>AAG	p.Q2713K		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2713	Cytoplasmic (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TCAAGACCAGCAGCATGGTGA	0.622													12	50					0.000978159	0.00104139	1	0	A	109815344	A	A	109815344	3	1	153	1	0	0	0	0	1	0	0	0	3237	711	25	4	8255	4	CELSR2	1	109815344	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	100810	109815344	139435277	13	27638											
LRIG2	9860	broad.mit.edu	37	chr1	113657144	113657144	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggagggagtcctgcccctCgtctcaactggactaaagat	9	9	11	12	1	1	1	1	0	1	1	4	4	2	4	3	3	2	0	3	3	3	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:113657144C>T	uc001edf.1	+	15	2374	c.2176C>T	c.(2176-2178)CGT>TGT	p.R726C	LRIG2_uc009wgn.1_Missense_Mutation_p.R623C	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	726	Ig-like C2-type 3.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TCCTGCCCCTCGTCTCAACTG	0.498													11	70					0	0	0	0	T	113657144	T	T	113657144	3	4	153	1	0	0	0	0	1	0	0	0	8995	884	31	1	2234	1	LRIG2	1	113657144	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	3841800	113657144	135593477	14	27639											
NBPF10	100132406	broad.mit.edu	37	chr1	145367753	145367753	+	Frame_Shift_Del	DEL	G	-	-																															ggggaaaaaaagaaggggaaGaagatcaaagaaggaaagaa																										TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:145367753delG	uc001end.3	+	85	10609	c.10574delG	c.(10573-10575)AGAfs	p.R3525fs	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3450											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		agaaggggaagaagatcaaag	0.244													---	---	---								-	145367753	-	-	145367753	7	5	153	1	0	1	0	1	0	0	0	0	10246	942	33	0	10679	0	NBPF10	1	145367753	Frame_Shift_Del	DEL	G	TCGA-CR-7386-01A-11D-2012-08	31710609	145367753	103882868	15	27640											
VPS45	11311	broad.mit.edu	37	chr1	150040002	150040002	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtacttctcatggataaaGagacggtgagtttgcttttg	11	14	11	5	1	1	2	1	1	1	1	2	4	1	3	0	2	2	3	0	2	4	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:150040002G>C	uc001etp.2	+	1	661	c.88G>C	c.(88-90)GAG>CAG	p.E30Q	VPS45_uc010pbp.1_RNA|VPS45_uc010pbq.1_5'UTR|VPS45_uc010pbs.1_Intron|VPS45_uc009wlm.1_Missense_Mutation_p.E30Q|VPS45_uc010pbr.1_Intron	NM_007259	NP_009190	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45A	30					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				central_nervous_system(1)|skin(1)	2	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CATGGATAAAGAGACGGTGAG	0.433													4	49					0	0	0	0	C	150040002	C	C	150040002	3	2	153	1	0	0	0	0	1	0	0	0	17279	943	33	2	90	2	VPS45	1	150040002	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	4672249	150040002	99210619	16	27641											
FLG	2312	broad.mit.edu	37	chr1	152284258	152284258	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctgctgactgctggtggcggGatccgtgtctttctcctgga	3	13	14	11	2	2	1	0	1	2	0	4	3	3	3	2	4	2	2	2	4	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:152284258G>C	uc001ezu.1	-	3	3140	c.3104C>G	c.(3103-3105)TCC>TGC	p.S1035C	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1035	Filaggrin 6.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGTGGCGGGATCCGTGTCT	0.567									Ichthyosis				41	651					0	0	0	0	C	152284258	C	C	152284258	3	2	153	1	0	0	0	0	1	0	0	0	5954	1174	41	2	9085	2	FLG	1	152284258	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	2244256	152284258	96966363	17	27642											
LCE2C	353140	broad.mit.edu	37	chr1	152648718	152648718	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctgctccctgagccaccAcaggccccgtctcttccacc	5	8	8	20	1	1	1	0	1	1	0	4	1	3	1	7	2	2	2	7	2	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:152648718A>G	uc001fah.2	+	2	282	c.227A>G	c.(226-228)CAC>CGC	p.H76R		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	76	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGAGCCACCACAGGCCCCGT	0.682													4	143					0	0	0	0	G	152648718	G	G	152648718	3	3	153	1	0	0	0	0	1	0	0	0	8707	159	6	5	229	5	LCE2C	1	152648718	Missense_Mutation	SNP	A	TCGA-CR-7386-01A-11D-2012-08	364460	152648718	96601903	18	27643											
PEA15	8682	broad.mit.edu	37	chr1	160181434	160181434	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaaggaagacatccccagcGaaaagagtgaggagatcact	16	4	12	9	1	1	4	1	1	0	3	2	7	2	5	2	2	1	1	2	2	4	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:160181434G>A	uc001fvk.2	+	2	290	c.100G>A	c.(100-102)GAA>AAA	p.E34K	uc001fvj.1_5'Flank|PEA15_uc001fvl.2_Missense_Mutation_p.E55K|PEA15_uc001fvm.2_Missense_Mutation_p.E34K	NM_003768	NP_003759	Q15121	PEA15_HUMAN	phosphoprotein enriched in astrocytes 15	34	DED.				anti-apoptosis|apoptosis|carbohydrate transport|negative regulation of glucose import	cytoplasm|microtubule associated complex	protein binding				0	all_cancers(52;3.11e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATCCCCAGCGAAAAGAGTGA	0.557													12	75					0	0	0	0	A	160181434	A	A	160181434	3	1	153	1	0	0	0	0	1	0	0	0	11765	1059	37	1	102	1	PEA15	1	160181434	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	7532716	160181434	89069187	19	27644											
KLHL20	27252	broad.mit.edu	37	chr1	173744918	173744918	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagagctgagcagtgctgaGagatacaaccccagaaccaa	16	4	10	11	0	0	5	0	2	0	3	0	6	0	5	3	0	6	3	3	0	4	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:173744918G>C	uc001gjc.2	+	10	1754	c.1575G>C	c.(1573-1575)GAG>GAC	p.E525D	KLHL20_uc010pmr.1_Missense_Mutation_p.E336D|KLHL20_uc009wwf.2_Missense_Mutation_p.E507D	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	525	Kelch 5.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						GCAGTGCTGAGAGATACAACC	0.453													5	75					0	0	0	0	C	173744918	C	C	173744918	3	2	153	1	0	0	0	0	1	0	0	0	8414	933	33	2	1609	2	KLHL20	1	173744918	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	13563484	173744918	75505703	20	27645											
TNN	63923	broad.mit.edu	37	chr1	175097823	175097823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaccatctacctgcatggcGatgccagccggcccctgcag	8	6	10	17	2	1	0	0	0	1	0	1	1	1	0	6	2	5	2	6	2	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:175097823G>A	uc001gkl.1	+	15	3384	c.3271G>A	c.(3271-3273)GAT>AAT	p.D1091N		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1091	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCTGCATGGCGATGCCAGCCG	0.602													10	82					0	0	0	0	A	175097823	A	A	175097823	3	1	153	1	0	0	0	0	1	0	0	0	16389	1058	37	1	3325	1	TNN	1	175097823	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1352905	175097823	74152798	21	27646											
PAPPA2	60676	broad.mit.edu	37	chr1	176740227	176740227	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgctcctgcctcactgcctCcaggacaaccacgacgtggg	7	8	10	16	2	1	0	1	0	0	0	3	2	3	1	5	2	4	1	5	2	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:176740227C>T	uc001gkz.2	+	17	5790	c.4626C>T	c.(4624-4626)CTC>CTT	p.L1542L	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1542	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CTCACTGCCTCCAGGACAACC	0.488													7	61					0	0	0	0	T	176740227	T	T	176740227	2	4	153	1	0	0	0	0	0	0	0	1	11487	842	30	2		2	PAPPA2	1	176740227	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	1642404	176740227	72510394	22	27647											
LAMC1	3915	broad.mit.edu	37	chr1	183103932	183103932	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccttctggagaaaggcaaGactgaacagcaggttggttt	13	9	12	7	0	1	3	0	1	1	2	1	4	1	3	1	4	3	4	1	4	4	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:183103932G>C	uc001gpy.3	+	23	4244	c.3987G>C	c.(3985-3987)AAG>AAC	p.K1329N		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	1329	Potential.|Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAAAGGCAAGACTGAACAGC	0.428													32	174					0	0	0	0	C	183103932	C	C	183103932	3	2	153	1	0	0	0	0	1	0	0	0	8654	933	33	2	4077	2	LAMC1	1	183103932	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	6363705	183103932	66146689	23	27648											
LAMC1	3915	broad.mit.edu	37	chr1	183106903	183106903	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaagcaactgcaggaagcaGaaaaagagctaaagagaaaa	22	3	11	5	0	0	4	0	1	0	3	0	6	0	5	0	1	5	4	0	1	9	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:183106903G>C	uc001gpy.3	+	26	4671	c.4414G>C	c.(4414-4416)GAA>CAA	p.E1472Q		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	1472	Potential.|Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCAGGAAGCAGAAAAAGAGCT	0.428													6	32					0	0	0	0	C	183106903	C	C	183106903	3	2	153	1	0	0	0	0	1	0	0	0	8654	943	33	2	4516	2	LAMC1	1	183106903	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	2971	183106903	66143718	24	27649											
PRG4	10216	broad.mit.edu	37	chr1	186277112	186277112	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caagcccgctccaactacccCtaaggggactgctccaacta	11	6	7	17	1	0	0	0	0	0	0	2	1	2	1	5	2	5	2	5	2	6	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:186277112C>G	uc001gru.3	+	7	2312	c.2261C>G	c.(2260-2262)CCT>CGT	p.P754R	PRG4_uc001grt.3_Missense_Mutation_p.P713R|PRG4_uc009wyl.2_Missense_Mutation_p.P661R|PRG4_uc009wym.2_Missense_Mutation_p.P620R|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	754	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|47; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CCAACTACCCCTAAGGGGACT	0.602													40	172					0	0	0	0	G	186277112	G	G	186277112	3	3	153	1	0	0	0	0	1	0	0	0	12543	681	24	4	2283	4	PRG4	1	186277112	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	3170209	186277112	62973509	25	27650											
C1orf106	55765	broad.mit.edu	37	chr1	200880920	200880920	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgccgcctggctatttcccGgcggggcggtacgtggtggt	2	10	17	12	5	0	0	0	0	0	0	1	0	1	0	3	7	2	2	3	7	2	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:200880920G>A	uc001gvo.2	+	9	1584	c.1554G>A	c.(1552-1554)CCG>CCA	p.P518P	C1orf106_uc010ppm.1_Silent_p.P433P	NM_018265	NP_060735	Q3KP66	CA106_HUMAN	hypothetical protein LOC55765 isoform 1	518										skin(2)|ovary(1)	3						GCTATTTCCCGGCGGGGCGGT	0.726													13	48					0	0	0	0	A	200880920	A	A	200880920	2	1	153	1	0	0	0	0	0	0	0	1	1989	1103	39	1		1	C1orf106	1	200880920	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	14603808	200880920	48369701	26	27651											
CDC42BPA	8476	broad.mit.edu	37	chr1	227268658	227268658	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctttcttgtctgctagatCtttaacctcttcttctaact	6	21	3	11	0	7	1	0	0	7	1	7	1	7	1	1	0	3	1	1	0	3	9			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:227268658C>A	uc001hqr.2	-	17	3359	c.2416G>T	c.(2416-2418)GAT>TAT	p.D806Y	CDC42BPA_uc001hqq.2_Missense_Mutation_p.D70Y|CDC42BPA_uc001hqs.2_Missense_Mutation_p.D725Y|CDC42BPA_uc009xes.2_Missense_Mutation_p.D806Y|CDC42BPA_uc010pvs.1_Missense_Mutation_p.D806Y|CDC42BPA_uc001hqp.2_5'UTR|CDC42BPA_uc001hqu.1_5'UTR	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	806	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TCTGCTAGATCTTTAACCTCT	0.358													18	64					1.99824e-07	2.16863e-07	1	0	A	227268658	A	A	227268658	3	1	153	1	0	0	0	0	1	0	0	0	3087	913	32	2	2823	2	CDC42BPA	1	227268658	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	26387738	227268658	21981963	27	27652											
TMEM178	130733	broad.mit.edu	37	chr2	39893244	39893244	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggcgccacaaggagagctgcGagcgcagccgcgcgggcgcc	7	1	18	15	7	0	1	0	0	0	1	0	3	0	1	3	3	4	2	3	3	1	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:39893244G>C	uc002rrt.2	+	1	155	c.130G>C	c.(130-132)GAG>CAG	p.E44Q	TMEM178_uc010fam.1_Missense_Mutation_p.E44Q	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	44	Extracellular (Potential).					integral to membrane					0		all_hematologic(82;0.248)				GGAGAGCTGCGAGCGCAGCCG	0.642													5	24					0	0	0	0	C	39893244	C	C	39893244	3	2	153	1	0	0	0	0	1	0	0	0	16161	1059	37	3	132	3	TMEM178	2	39893244	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		39893244	203306129	28	27653											
CCDC88A	55704	broad.mit.edu	37	chr2	55546086	55546086	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaattattgttctgtgtctCaagttgcttcagttgagttt	8	19	8	6	0	3	1	2	1	2	0	4	1	3	1	0	0	1	5	0	0	3	7			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:55546086C>G	uc002ryv.2	-	19	4056	c.3214G>C	c.(3214-3216)GAG>CAG	p.E1072Q	CCDC88A_uc010yoz.1_Missense_Mutation_p.E1073Q|CCDC88A_uc010ypa.1_Missense_Mutation_p.E1072Q|CCDC88A_uc002ryu.2_Missense_Mutation_p.E355Q|CCDC88A_uc002rys.2_Missense_Mutation_p.E58Q|CCDC88A_uc002ryw.2_Missense_Mutation_p.E356Q|CCDC88A_uc010fby.1_5'UTR	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1073	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TTCTGTGTCTCAAGTTGCTTC	0.383													4	53					0	0	0	0	G	55546086	G	G	55546086	3	3	153	1	0	0	0	0	1	0	0	0	2876	835	29	2	2454	2	CCDC88A	2	55546086	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	15652842	55546086	187653287	29	27654											
RGPD4	285190	broad.mit.edu	37	chr2	108487257	108487257	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatttcggaaccaggaaatCaagaaaaggaaagtgaaaag	20	5	11	5	1	1	2	1	1	0	1	2	5	1	5	1	3	1	1	1	3	8	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:108487257C>T	uc010ywk.1	+	20	2879	c.2797C>T	c.(2797-2799)CAA>TAA	p.Q933*	RGPD4_uc002tdu.2_Nonsense_Mutation_p.Q120*|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	933					intracellular transport		binding			skin(2)	2						ACCAGGAAATCAAGAAAAGGA	0.413													54	258					0	0	0	0	T	108487257	T	T	108487257	4	4	153	1	0	0	0	0	0	1	0	0	13353	827	29	2	2875	2	RGPD4	2	108487257	Nonsense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	52941171	108487257	134712116	30	27655											
GALNT3	2591	broad.mit.edu	37	chr2	166615260	166615260	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatttccataaacttactctGaaagacatttctatattttc	14	17	2	8	0	2	2	0	1	2	1	4	2	3	2	1	0	2	0	1	0	7	8			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:166615260G>A	uc010fph.1	-	6	1575	c.1188C>T	c.(1186-1188)TTC>TTT	p.F396F	GALNT3_uc010fpi.1_Silent_p.F396F	NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	396	Catalytic subdomain B.|Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						AACTTACTCTGAAAGACATTT	0.308													8	54					0	0	0	0	A	166615260	A	A	166615260	2	1	153	1	0	0	0	0	0	0	0	1	6249	1281	45	2		2	GALNT3	2	166615260	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	58128003	166615260	76584113	31	27656											
STK39	27347	broad.mit.edu	37	chr2	169023849	169023849	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagccaaagttcatctttGaccacaaaagaggtgtaata	16	9	7	9	0	2	2	1	1	1	1	2	2	2	2	3	1	1	2	3	1	5	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:169023849G>A	uc002uea.2	-	3	550	c.390C>T	c.(388-390)GTC>GTT	p.V130V		NM_013233	NP_037365	Q9UEW8	STK39_HUMAN	serine threonine kinase 39 (STE20/SPS1 homolog,	130	Protein kinase.				response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2						GTTCATCTTTGACCACAAAAG	0.378													4	37					0	0	0	0	A	169023849	A	A	169023849	2	1	153	1	0	0	0	0	0	0	0	1	15371	1277	45	2		2	STK39	2	169023849	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	2408589	169023849	74175524	32	27657											
LRP2	4036	broad.mit.edu	37	chr2	170101261	170101261	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgtgtcacagacccagttCtttgagatacactggtgatt	9	14	9	9	0	3	3	1	2	2	2	3	4	3	3	1	1	1	1	1	1	1	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:170101261C>T	uc002ues.2	-	22	3585	c.3372G>A	c.(3370-3372)AAG>AAA	p.K1124K	LRP2_uc010zdf.1_Silent_p.K987K	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1124	LDL-receptor class A 10.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGACCCAGTTCTTTGAGATAC	0.493													20	114					0	0	0	0	T	170101261	T	T	170101261	2	4	153	1	0	0	0	0	0	0	0	1	9006	912	32	2		2	LRP2	2	170101261	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	1077412	170101261	73098112	33	27658											
WIPF1	7456	broad.mit.edu	37	chr2	175432655	175432655	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggtgggggaggtgcccCagcactgggcctatcaggag	7	6	19	9	0	1	0	1	0	0	0	1	3	1	3	3	7	2	1	3	7	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:175432655C>G	uc002uiy.2	-	7	1608	c.1276G>C	c.(1276-1278)GGG>CGG	p.G426R	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.G426R|WIPF1_uc010fqt.1_Missense_Mutation_p.G426R|WIPF1_uc002uiz.2_Missense_Mutation_p.G426R|WIPF1_uc002ujb.1_Missense_Mutation_p.G426R	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	426	Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						GGAGGTGCCCCAGCACTGGGC	0.602													10	64					0	0	0	0	G	175432655	G	G	175432655	3	3	153	1	0	0	0	0	1	0	0	0	17435	594	21	4	247	4	WIPF1	2	175432655	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	5331394	175432655	67766718	34	27659											
TTN	7273	broad.mit.edu	37	chr2	179414566	179414566	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccagtaatattggtgaatCttattggcccaactactttt	10	15	6	10	0	1	1	0	1	1	0	1	1	1	1	3	2	2	1	3	2	6	8			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:179414566C>T	uc010zfg.1	-	287	84403	c.84179G>A	c.(84178-84180)AGA>AAA	p.R28060K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R21755K|TTN_uc010zfi.1_Missense_Mutation_p.R21688K|TTN_uc010zfj.1_Missense_Mutation_p.R21563K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28987							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTGGTGAATCTTATTGGCCC	0.403													5	109					0	0	0	0	T	179414566	T	T	179414566	3	4	153	1	0	0	0	0	1	0	0	0	16803	913	32	2	16196	2	TTN	2	179414566	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	3981911	179414566	63784807	35	27660											
AOX1	316	broad.mit.edu	37	chr2	201534448	201534448	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agattaggatggcctgtgaaGacaagttcacaaaaatggta	16	9	11	5	0	1	3	1	1	0	2	1	4	1	4	1	3	0	2	1	3	6	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:201534448G>A	uc002uvx.2	+	34	4050	c.3949G>A	c.(3949-3951)GAC>AAC	p.D1317N	AOX1_uc010zhf.1_Missense_Mutation_p.D873N|AOX1_uc010fsu.2_Missense_Mutation_p.D683N	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	1317					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity	p.D1317V(1)		ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GGCCTGTGAAGACAAGTTCAC	0.448													17	114					0	0	0	0	A	201534448	A	A	201534448	3	1	153	1	0	0	0	0	1	0	0	0	729	942	33	2	4083	2	AOX1	2	201534448	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	22119882	201534448	41664925	36	27661											
PNKD	25953	broad.mit.edu	37	chr2	219204763	219204763	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtccccaggagtgaaggtgCttcccatccctgtcctctcg	5	11	10	15	1	1	1	0	1	1	0	6	2	5	2	5	2	1	1	5	2	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:219204763C>A	uc002vhn.2	+	4	508	c.364C>A	c.(364-366)CTT>ATT	p.L122I	PNKD_uc002vhq.2_Missense_Mutation_p.L98I	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	122						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGTGAAGGTGCTTCCCATCCC	0.652													13	63					0.000151284	0.000162922	1	0	A	219204763	A	A	219204763	3	1	153	1	0	0	0	0	1	0	0	0	12201	797	28	4	743	4	PNKD	2	219204763	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	17670315	219204763	23994610	37	27662											
EPHA4	2043	broad.mit.edu	37	chr2	222298867	222298867	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacatagagacttacatcttGattggacatatcccaatagg	15	11	7	8	0	1	2	0	1	1	1	2	4	2	3	1	2	2	0	1	2	6	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:222298867G>A	uc002vmq.2	-	14	2533	c.2491C>T	c.(2491-2493)CAA>TAA	p.Q831*	EPHA4_uc002vmr.2_Nonsense_Mutation_p.Q831*|EPHA4_uc010zlm.1_Nonsense_Mutation_p.Q772*|EPHA4_uc010zln.1_Nonsense_Mutation_p.Q831*	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	831	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CTTACATCTTGATTGGACATA	0.408													9	70					0	0	0	0	A	222298867	A	A	222298867	4	1	153	1	0	0	0	0	0	1	0	0	5193	1299	45	2	485	2	EPHA4	2	222298867	Nonsense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	3094104	222298867	20900506	38	27663											
CHRNG	1146	broad.mit.edu	37	chr2	233405103	233405103	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acccccagaacgagcgagagGaagccctcaccaccaatgtc	13	3	9	16	2	1	2	1	0	0	2	2	5	1	3	5	1	3	0	5	1	3	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:233405103G>A	uc002vsx.1	+	3	229	c.208G>A	c.(208-210)GAA>AAA	p.E70K	CHRNG_uc010fyd.2_Missense_Mutation_p.E70K|CHRNG_uc010fye.1_Missense_Mutation_p.E70K	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	70	Extracellular (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CGAGCGAGAGGAAGCCCTCAC	0.632													17	78					0	0	0	0	A	233405103	A	A	233405103	3	1	153	1	0	0	0	0	1	0	0	0	3411	1175	41	2	218	2	CHRNG	2	233405103	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	11106236	233405103	9794270	39	27664											
SH3BP4	23677	broad.mit.edu	37	chr2	235949960	235949960	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtcatgcccagcctggatGagctgaatcccaaaagtact	11	8	9	13	1	1	2	1	2	0	0	2	3	2	3	4	1	4	2	4	1	4	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:235949960G>A	uc002vvp.2	+	4	940	c.547G>A	c.(547-549)GAG>AAG	p.E183K	SH3BP4_uc010fym.2_Missense_Mutation_p.E183K|SH3BP4_uc002vvq.2_Missense_Mutation_p.E183K	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	183					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CAGCCTGGATGAGCTGAATCC	0.493													29	115					0	0	0	0	A	235949960	A	A	235949960	3	1	153	1	0	0	0	0	1	0	0	0	14311	1291	45	2	553	2	SH3BP4	2	235949960	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	2544857	235949960	7249413	40	27665											
TOPBP1	11073	broad.mit.edu	37	chr3	133368367	133368367	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttactttcaggcttatgtGaaactggaatttccactggc	9	15	8	9	0	1	1	1	1	0	0	2	2	2	2	1	3	2	1	1	3	4	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:133368367G>C	uc003eps.2	-	10	1496	c.1364C>G	c.(1363-1365)TCA>TGA	p.S455*		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	455					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						AGGCTTATGTGAAACTGGAAT	0.393								Other_conserved_DNA_damage_response_genes					35	124					0	0	0	0	C	133368367	C	C	133368367	4	2	153	1	0	0	0	0	0	1	0	0	16436	1294	45	2	3280	2	TOPBP1	3	133368367	Nonsense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		133368367	64654063	41	27666											
EPHB1	2047	broad.mit.edu	37	chr3	134911464	134911464	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtttgaaactgccaggcaaGagggaaatctacgtggccat	12	8	12	9	2	1	2	0	1	1	1	1	3	1	3	2	3	3	2	2	3	4	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:134911464G>C	uc003eqt.2	+	11	2149	c.1929G>C	c.(1927-1929)AAG>AAC	p.K643N	EPHB1_uc003equ.2_Missense_Mutation_p.K204N	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	643	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TGCCAGGCAAGAGGGAAATCT	0.527													10	37					0	0	0	0	C	134911464	C	C	134911464	3	2	153	1	0	0	0	0	1	0	0	0	5198	933	33	2	1971	2	EPHB1	3	134911464	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1543097	134911464	63110966	42	27667											
ESYT3	83850	broad.mit.edu	37	chr3	138187688	138187688	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttgactacctgaatggtGaatatcgagccaaaaaactc	14	11	7	9	1	0	3	0	3	0	0	2	4	0	3	2	1	3	0	2	1	7	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:138187688G>A	uc003esk.2	+	14	1625	c.1399G>A	c.(1399-1401)GAA>AAA	p.E467K	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	467	C2 2.					integral to membrane|plasma membrane					0						CCTGAATGGTGAATATCGAGC	0.463													44	363					0	0	0	0	A	138187688	A	A	138187688	3	1	153	1	0	0	0	0	1	0	0	0	5290	1291	45	2	1453	2	ESYT3	3	138187688	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	3276224	138187688	59834742	43	27668											
ATR	545	broad.mit.edu	37	chr3	142241603	142241603	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcagctgaatcttgagctcgGctattatcagcatacgcaag	11	10	10	10	2	2	2	1	2	1	0	3	2	2	2	0	1	4	6	0	1	5	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:142241603G>A	uc003eux.3	-	23	4355	c.4233C>T	c.(4231-4233)AGC>AGT	p.S1411S		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1411					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CTTGAGCTCGGCTATTATCAG	0.358								Other_conserved_DNA_damage_response_genes					42	121					0	0	0	0	A	142241603	A	A	142241603	2	1	153	1	0	0	0	0	0	0	0	1	1206	1194	42	4		4	ATR	3	142241603	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	4053915	142241603	55780827	44	27669											
ATR	545	broad.mit.edu	37	chr3	142285073	142285073	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatcacggaggttggctgaGagtcagttttctttacaagt	10	13	11	7	1	3	1	2	1	1	1	3	3	3	2	0	3	1	3	0	3	2	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:142285073G>C	uc003eux.3	-	3	304	c.182C>G	c.(181-183)TCT>TGT	p.S61C		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	61					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						GGTTGGCTGAGAGTCAGTTTT	0.378								Other_conserved_DNA_damage_response_genes					4	36					0	0	0	0	C	142285073	C	C	142285073	3	2	153	1	0	0	0	0	1	0	0	0	1206	942	33	2	7932	2	ATR	3	142285073	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	43470	142285073	55737357	45	27670											
C3orf79	152118	broad.mit.edu	37	chr3	153202424	153202424	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catggatgttcagttgccatCttctgcctactcctgagctt	6	15	8	12	0	3	1	1	1	2	0	4	2	4	2	3	1	4	3	3	1	1	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:153202424C>G	uc003ezt.2	+	1	141	c.79C>G	c.(79-81)CTT>GTT	p.L27V		NM_001101337	NP_001094807	P0CE67	CC079_HUMAN	chromosome 3 open reading frame 79	27											0						CAGTTGCCATCTTCTGCCTAC	0.413													19	236					0	0	0	0	G	153202424	G	G	153202424	3	3	153	1	0	0	0	0	1	0	0	0	2256	913	32	2	81	2	C3orf79	3	153202424	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	10917351	153202424	44820006	46	27671											
PLCH1	23007	broad.mit.edu	37	chr3	155200325	155200325	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaattacactctcctgcaGaattgcagttgaatgtaggt	12	12	10	7	0	1	2	0	1	1	1	2	3	1	3	1	2	3	4	1	2	5	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:155200325G>A	uc011bok.1	-	23	3791	c.3514C>T	c.(3514-3516)CTG>TTG	p.L1172L	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.L1134L	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1172					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CTCTCCTGCAGAATTGCAGTT	0.458													8	42					0	0	0	0	A	155200325	A	A	155200325	2	1	153	1	0	0	0	0	0	0	0	1	12092	933	33	2		2	PLCH1	3	155200325	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1997901	155200325	42822105	47	27672											
DGKG	1608	broad.mit.edu	37	chr3	185882740	185882740	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctgcactcttcaggccGgtgtagatctgccccatctc	5	11	9	16	1	4	1	1	0	3	1	5	1	4	1	4	2	3	2	4	2	1	2	rs137961016	byFrequency	TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:185882740G>A	uc003fqa.2	-	23	2700	c.2163C>T	c.(2161-2163)ACC>ACT	p.T721T	DGKG_uc003fqb.2_Silent_p.T682T|DGKG_uc003fqc.2_Silent_p.T696T|DGKG_uc011brx.1_Silent_p.T662T	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	721					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TCTTCAGGCCGGTGTAGATCT	0.587													13	52					0	0	0	0	A	185882740	A	A	185882740	2	1	153	1	0	0	0	0	0	0	0	1	4491	1103	39	1		1	DGKG	3	185882740	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	30682415	185882740	12139690	48	27673											
FETUB	26998	broad.mit.edu	37	chr3	186358276	186358276	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctccttcccctggcactCtgcatcctagtcctgtgctg	3	13	8	17	0	1	0	0	0	1	0	5	0	5	0	5	1	3	4	5	1	1	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:186358276C>A	uc010hyq.2	+	2	288	c.27C>A	c.(25-27)CTC>CTA	p.L9L	FETUB_uc011brz.1_Intron|FETUB_uc003fqn.2_Silent_p.L9L|FETUB_uc003fqo.2_Translation_Start_Site|FETUB_uc010hyr.2_Silent_p.L9L|FETUB_uc010hys.2_Translation_Start_Site|FETUB_uc003fqp.3_Silent_p.L9L	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	9				L -> P (in Ref. 6; AAH74734).		extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		CCCTGGCACTCTGCATCCTAG	0.597													77	209					1.41257e-51	1.56952e-51	1	0	A	186358276	A	A	186358276	2	1	153	1	0	0	0	0	0	0	0	1	5853	900	32	2		2	FETUB	3	186358276	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	475536	186358276	11664154	49	27674											
ST6GAL1	6480	broad.mit.edu	37	chr3	186793540	186793540	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggcacagatgaggacatCtacctgcttggaaaagccac	13	6	11	11	0	1	2	0	1	1	1	1	4	1	4	2	3	3	2	2	3	3	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:186793540C>T	uc003frb.2	+	8	1602	c.1170C>T	c.(1168-1170)ATC>ATT	p.I390I	ST6GAL1_uc003frc.2_Silent_p.I159I|ST6GAL1_uc003frd.2_Silent_p.I390I	NM_173216	NP_775323	P15907	SIAT1_HUMAN	ST6 beta-galactosamide	390	Lumenal (Potential).				humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)	1	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		ATGAGGACATCTACCTGCTTG	0.507													5	81					0	0	0	0	T	186793540	T	T	186793540	2	4	153	1	0	0	0	0	0	0	0	1	15287	903	32	2		2	ST6GAL1	3	186793540	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	435264	186793540	11228890	50	27675											
RTP1	132112	broad.mit.edu	37	chr3	186917561	186917561	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accagcctgcgcgagcagtgCtacggcgagcgtggcggcca	7	4	16	14	6	0	0	0	0	0	0	0	2	0	0	3	3	6	2	3	3	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:186917561C>G	uc003frg.2	+	2	525	c.495C>G	c.(493-495)TGC>TGG	p.C165W		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	165	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		GCGAGCAGTGCTACGGCGAGC	0.687													21	29					0	0	0	0	G	186917561	G	G	186917561	3	3	153	1	0	0	0	0	1	0	0	0	13798	805	28	4	501	4	RTP1	3	186917561	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	124021	186917561	11104869	51	27676											
C3orf59	151963	broad.mit.edu	37	chr3	192516720	192516720	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgatggctttgcaggcctGataggcctgcatgaggctgc	7	10	15	9	0	0	3	0	3	0	0	0	4	0	3	2	4	3	4	2	4	1	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:192516720G>C	uc011bsp.1	-	2	1252	c.931C>G	c.(931-933)CAG>GAG	p.Q311E		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	311											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGCAGGCCTGATAGGCCTGC	0.557													4	46					0	0	0	0	C	192516720	C	C	192516720	3	2	153	1	0	0	0	0	1	0	0	0	2247	1299	45	2	548	2	C3orf59	3	192516720	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	5599159	192516720	5505710	52	27677											
IQCG	84223	broad.mit.edu	37	chr3	197665630	197665630	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtctagattcgttccttCtagattcatttctctgcttt	5	22	5	9	1	4	2	1	0	3	2	7	2	5	2	1	0	1	2	1	0	2	9			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:197665630C>A	uc003fyo.2	-	4	450	c.304G>T	c.(304-306)GAA>TAA	p.E102*	IQCG_uc003fyn.2_Nonsense_Mutation_p.E4*|IQCG_uc003fyp.2_Nonsense_Mutation_p.E102*|IQCG_uc003fyq.3_Nonsense_Mutation_p.E102*	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	102											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		TTCGTTCCTTCTAGATTCATT	0.338													27	184					2.44723e-14	2.69774e-14	1	0	A	197665630	A	A	197665630	4	1	153	1	0	0	0	0	0	1	0	0	7849	922	32	2	1059	2	IQCG	3	197665630	Nonsense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	5148910	197665630	356800	53	27678											
DGKQ	1609	broad.mit.edu	37	chr4	957073	957073	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagctgtctgggggcagcttCgcgtgctgacagacaggggg	6	7	18	10	2	1	2	0	1	1	1	2	2	1	2	0	4	3	4	0	4	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:957073C>T	uc003gbw.2	-	16	1814	c.1740G>A	c.(1738-1740)GCG>GCA	p.A580A	DGKQ_uc010ibn.2_Silent_p.A567A	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	580					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GGGGCAGCTTCGCGTGCTGAC	0.652													10	38					0	0	0	0	T	957073	T	T	957073	2	4	153	1	0	0	0	0	0	0	0	1	4495	871	31	1		1	DGKQ	4	957073	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08		957073	190197203	54	27679											
HAUS3	79441	broad.mit.edu	37	chr4	2242704	2242704	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accccaattttgttgtatctGatatgggtttacggtgttga	8	17	10	6	1	1	2	0	2	1	0	1	2	1	2	2	2	1	4	2	2	4	8			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:2242704G>C	uc003ges.1	-	2	200	c.-30C>G	c.(-32--28)ATCAG>ATGAG		POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Translation_Start_Site|HAUS3_uc003get.1_Translation_Start_Site	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4						TGTTGTATCTGATATGGGTTT	0.308													14	46					0	0	0	0	C	2242704	C	C	2242704	1	2	153	1	0	0	0	0	0	0	0	0	7006	1305	45	2		2	HAUS3	4	2242704	Translation_Start_Site	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1285631	2242704	188911572	55	27680											
ADRA2C	152	broad.mit.edu	37	chr4	3768939	3768939	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcgccgcctacccgcagtgCggcctcaacgacgagacctg	7	4	13	17	6	1	1	1	0	0	1	1	3	1	1	5	2	3	1	5	2	2	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:3768939C>T	uc003ghm.2	+	1	644	c.606C>T	c.(604-606)TGC>TGT	p.C202C	ADRA2C_uc010icx.2_Silent_p.C202C	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	202	Extracellular (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	ACCCGCAGTGCGGCCTCAACG	0.672													3	25					0	0	0	0	T	3768939	T	T	3768939	2	4	153	1	0	0	0	0	0	0	0	1	339	776	27	1		1	ADRA2C	4	3768939	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	1526235	3768939	187385337	56	27681											
WDR19	57728	broad.mit.edu	37	chr4	39276495	39276495	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctgaagaactctgctttCagcttcgcagctatgttgat	8	13	10	10	1	2	3	1	2	1	1	3	3	2	3	1	1	4	5	1	1	3	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:39276495C>T	uc003gtv.2	+	33	3787	c.3633C>T	c.(3631-3633)TTC>TTT	p.F1211F	WDR19_uc011byi.1_Silent_p.F1051F|WDR19_uc003gtw.1_Silent_p.F808F	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1211					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						ACTCTGCTTTCAGCTTCGCAG	0.488													8	96					0	0	0	0	T	39276495	T	T	39276495	2	4	153	1	0	0	0	0	0	0	0	1	17347	825	29	2		2	WDR19	4	39276495	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	35507556	39276495	151877781	57	27682											
GUF1	60558	broad.mit.edu	37	chr4	44700691	44700691	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttctgaaaacacaatcttCtaaataattggtgggaaaac	17	11	7	6	0	3	1	0	1	3	0	3	2	3	2	0	2	2	1	0	2	8	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:44700691C>G	uc003gww.3	+	17	2210	c.2003C>G	c.(2002-2004)TCT>TGT	p.S668C	GUF1_uc011bza.1_Missense_Mutation_p.S75C	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	668					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						ACACAATCTTCTAAATAATTG	0.308													9	26					0	0	0	0	G	44700691	G	G	44700691	3	3	153	1	0	0	0	0	1	0	0	0	6938	913	32	2	2069	2	GUF1	4	44700691	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	5424196	44700691	146453585	58	27683											
RUFY3	22902	broad.mit.edu	37	chr4	71628306	71628306	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctgagtatcaagggcttGattgaatcagctctgaacct	12	11	10	8	0	3	4	2	4	1	0	3	4	3	4	1	1	3	4	1	1	5	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:71628306G>C	uc003hfq.2	+	2	844	c.249G>C	c.(247-249)TTG>TTC	p.L83F	RUFY3_uc003hfp.3_Missense_Mutation_p.L143F|RUFY3_uc011cax.1_Missense_Mutation_p.L101F|RUFY3_uc003hfr.2_Missense_Mutation_p.L83F|RUFY3_uc011cay.1_Missense_Mutation_p.L19F	NM_014961	NP_055776	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 2	83					negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			TCAAGGGCTTGATTGAATCAG	0.473													29	200					0	0	0	0	C	71628306	C	C	71628306	3	2	153	1	0	0	0	0	1	0	0	0	13805	1281	45	2	617	2	RUFY3	4	71628306	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	26927615	71628306	119525970	59	27684											
GK2	2712	broad.mit.edu	37	chr4	80328806	80328806	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcctcctgtcaaactccaGataagccatgaatcaatggt	13	10	6	12	0	2	2	2	1	0	1	5	2	5	2	4	1	2	0	4	1	4	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:80328806G>C	uc003hlu.2	-	1	567	c.549C>G	c.(547-549)ATC>ATG	p.I183M		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	183					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						TCAAACTCCAGATAAGCCATG	0.403													4	80					0	0	0	0	C	80328806	C	C	80328806	3	2	153	1	0	0	0	0	1	0	0	0	6458	932	33	2	1116	2	GK2	4	80328806	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	8700500	80328806	110825470	60	27685											
THAP9	79725	broad.mit.edu	37	chr4	83838784	83838784	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatttgaaaaatcatgtactGaaagtgaatagtgccaccca	17	10	7	7	0	1	3	1	3	0	0	1	3	1	3	2	0	2	1	2	0	7	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:83838784G>C	uc003hnt.2	+	5	1538	c.1419G>C	c.(1417-1419)CTG>CTC	p.L473L	THAP9_uc003hns.1_Silent_p.L329L|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_Silent_p.L190L	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	473							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				ATCATGTACTGAAAGTGAATA	0.388													21	104					0	0	0	0	C	83838784	C	C	83838784	2	2	153	1	0	0	0	0	0	0	0	1	15917	1277	45	2		2	THAP9	4	83838784	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	3509978	83838784	107315492	61	27686											
MEPE	56955	broad.mit.edu	37	chr4	88766888	88766888	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggtttgcaggcccaagtGaagctgagagtactcatctt	10	10	12	9	0	2	2	1	2	1	1	2	3	2	2	1	2	3	4	1	2	3	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:88766888G>A	uc003hqy.2	+	4	907	c.868G>A	c.(868-870)GAA>AAA	p.E290K	MEPE_uc010ikn.2_Missense_Mutation_p.E177K	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	290					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AGGCCCAAGTGAAGCTGAGAG	0.448													9	55					0	0	0	0	A	88766888	A	A	88766888	3	1	153	1	0	0	0	0	1	0	0	0	9531	1291	45	2	878	2	MEPE	4	88766888	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	4928104	88766888	102387388	62	27687											
FAM13A	10144	broad.mit.edu	37	chr4	89652580	89652580	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgttccaggagttcaggtCtaagagagaggaagcattgc	11	9	15	6	0	2	2	1	0	1	2	3	5	3	4	1	4	2	3	1	4	2	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:89652580C>G	uc003hse.1	-	23	3052	c.2844_splice	c.e23-1	p.I948_splice	FAM13A_uc011cdp.1_Splice_Site_p.I50_splice|FAM13A_uc003hsa.1_Splice_Site_p.I391_splice|FAM13A_uc003hsb.1_Splice_Site_p.I622_splice|FAM13A_uc003hsd.1_Splice_Site_p.I594_splice|FAM13A_uc003hsc.1_Splice_Site_p.I608_splice|FAM13A_uc011cdq.1_Splice_Site_p.I594_splice|FAM13A_uc003hsf.1_Splice_Site_p.I534_splice|FAM13A_uc003hsg.1_Intron	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						GAGTTCAGGTCTAAGAGAGAG	0.398													4	31					0	0	0	0	G	89652580	G	G	89652580	5	3	153	1	0	0	0	0	0	0	1	0	5480	927	32	2	236	2	FAM13A	4	89652580	Splice_Site	SNP	C	TCGA-CR-7386-01A-11D-2012-08	885692	89652580	101501696	63	27688											
ENPEP	2028	broad.mit.edu	37	chr4	111397596	111397596	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttgcggagagagagggctCtaagagatactgcattcaaa	13	9	12	7	1	2	3	1	0	1	3	2	6	2	3	0	2	3	2	0	2	3	4	rs147278588		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:111397596C>G	uc003iab.3	+	1	368	c.26C>G	c.(25-27)TCT>TGT	p.S9C		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	9	Cytoplasmic (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AGAGAGGGCTCTAAGAGATAC	0.433													17	121					0	0	0	0	G	111397596	G	G	111397596	3	3	153	1	0	0	0	0	1	0	0	0	5152	913	32	2	28	2	ENPEP	4	111397596	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	21745016	111397596	79756680	64	27689											
ANK2	287	broad.mit.edu	37	chr4	114158298	114158298	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgccgcacttctgcttcaGaatgaccacaatgctgacgt	9	11	8	13	2	3	3	1	2	2	1	3	3	3	3	2	0	3	3	2	0	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:114158298G>C	uc003ibe.3	+	6	739	c.639G>C	c.(637-639)CAG>CAC	p.Q213H	ANK2_uc003ibd.3_Missense_Mutation_p.Q192H|ANK2_uc003ibf.3_Missense_Mutation_p.Q213H|ANK2_uc003ibc.2_Missense_Mutation_p.Q189H|ANK2_uc011cgb.1_Missense_Mutation_p.Q228H	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	213	ANK 6.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTCTGCTTCAGAATGACCACA	0.488													11	125					0	0	0	0	C	114158298	C	C	114158298	3	2	153	1	0	0	0	0	1	0	0	0	621	933	33	2	686	2	ANK2	4	114158298	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	2760702	114158298	76995978	65	27690											
TNIP3	79931	broad.mit.edu	37	chr4	122068285	122068285	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcttgattaagtctctcTcgatccgatcgttccttttt	5	20	5	11	3	3	1	0	1	3	0	9	3	5	1	2	0	0	1	2	0	1	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:122068285T>C	uc010ing.2	-	7	850	c.654A>G	c.(652-654)CGA>CGG	p.R218R	TNIP3_uc010inh.2_Silent_p.R218R|TNIP3_uc011cgj.1_Silent_p.R276R	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	218	Potential.									ovary(1)	1						TAAGTCTCTCTCGATCCGATC	0.373													7	70					0	0	0	0	C	122068285	C	C	122068285	2	2	153	1	0	0	0	0	0	0	0	1	16382	1538	54	5		5	TNIP3	4	122068285	Silent	SNP	T	TCGA-CR-7386-01A-11D-2012-08	7909987	122068285	69085991	66	27691											
QRFPR	84109	broad.mit.edu	37	chr4	122301463	122301463	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcggggcgcgactcttacCccccagccagttgtcggaaa	8	6	13	14	4	1	0	0	0	1	0	2	3	1	1	4	3	3	1	4	3	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:122301463C>A	uc010inj.1	-	1	719	c.340G>T	c.(340-342)GGT>TGT	p.G114C	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_Missense_Mutation_p.G114C|QRFPR_uc010inl.1_Missense_Mutation_p.G114C	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	114	Extracellular (Potential).					plasma membrane	neuropeptide Y receptor activity				0						CGACTCTTACCCCCCAGCCAG	0.443													12	73					0.000978159	0.00104139	1	0	A	122301463	A	A	122301463	3	1	153	1	0	0	0	0	1	0	0	0	12943	637	22	4	979	4	QRFPR	4	122301463	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	233178	122301463	68852813	67	27692											
MFSD8	256471	broad.mit.edu	37	chr4	128842692	128842692	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcttacctgaggttttggtCctagaatttttgaatataga	10	16	10	5	0	0	4	0	2	0	2	1	4	1	4	2	3	1	2	2	3	6	8			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:128842692C>A	uc003ifp.2	-	12	1500	c.1337G>T	c.(1336-1338)GGA>GTA	p.G446V	MFSD8_uc011cgu.1_Missense_Mutation_p.G401V|MFSD8_uc011cgv.1_3'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	446	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						AGGTTTTGGTCCTAGAATTTT	0.378													6	50					0.00116845	0.00123458	1	0	A	128842692	A	A	128842692	3	1	153	1	0	0	0	0	1	0	0	0	9591	855	30	2	227	2	MFSD8	4	128842692	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	6541229	128842692	62311584	68	27693											
GLRB	2743	broad.mit.edu	37	chr4	158057783	158057783	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaaaaaagtgccaattttCatgatgtgacccaggaaaac	17	9	8	7	0	1	3	1	3	0	0	1	4	1	4	2	1	2	0	2	1	6	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:158057783C>T	uc003ipj.2	+	5	662	c.460C>T	c.(460-462)CAT>TAT	p.H154Y		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	154	Extracellular (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	TGCCAATTTTCATGATGTGAC	0.353													17	106					0	0	0	0	T	158057783	T	T	158057783	3	4	153	1	0	0	0	0	1	0	0	0	6495	826	29	2	474	2	GLRB	4	158057783	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	29215091	158057783	33096493	69	27694											
FAT1	2195	broad.mit.edu	37	chr4	187532590	187532590	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttcatttccacttattattGagtaggtgatttctgcattt	8	20	7	6	0	2	2	1	2	1	0	3	2	3	2	1	1	1	3	1	1	3	8			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:187532590G>C	uc003izf.2	-	14	9991	c.9803C>G	c.(9802-9804)TCA>TGA	p.S3268*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3268	Extracellular (Potential).|Cadherin 30.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACTTATTATTGAGTAGGTGAT	0.403										HNSCC(5;0.00058)			7	27					0	0	0	0	C	187532590	C	C	187532590	4	2	153	1	0	0	0	0	0	1	0	0	5721	1294	45	2	4019	2	FAT1	4	187532590	Nonsense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	29474807	187532590	3621686	70	27695											
FAT1	2195	broad.mit.edu	37	chr4	187539227	187539227	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taacttggccgttggttcctGagtcagcatcagatgccctg	7	12	11	11	1	2	2	2	1	0	1	3	2	3	2	3	2	3	3	3	2	1	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:187539227G>C	uc003izf.2	-	10	8701	c.8513C>G	c.(8512-8514)TCA>TGA	p.S2838*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2838	Extracellular (Potential).|Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTTGGTTCCTGAGTCAGCATC	0.448										HNSCC(5;0.00058)			15	106					0	0	0	0	C	187539227	C	C	187539227	4	2	153	1	0	0	0	0	0	1	0	0	5721	1294	45	2	5325	2	FAT1	4	187539227	Nonsense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	6637	187539227	3615049	71	27696											
FAT1	2195	broad.mit.edu	37	chr4	187629184	187629184	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatctgatactgtaccaactGaagttcatctgcatcaatag	14	12	6	9	0	4	2	2	2	2	0	4	2	4	2	1	0	4	3	1	0	7	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:187629184G>A	uc003izf.2	-	2	1986	c.1798C>T	c.(1798-1800)CAG>TAG	p.Q600*	FAT1_uc010iso.1_Nonsense_Mutation_p.Q600*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	600	Extracellular (Potential).|Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGTACCAACTGAAGTTCATCT	0.408										HNSCC(5;0.00058)			6	41					0	0	0	0	A	187629184	A	A	187629184	4	1	153	1	0	0	0	0	0	1	0	0	5721	1299	45	2	12072	2	FAT1	4	187629184	Nonsense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	89957	187629184	3525092	72	27697											
DNAH5	1767	broad.mit.edu	37	chr5	13841896	13841896	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaagatgcaatgaggactGagattcttccaaaagagaat	17	8	9	7	0	1	4	0	2	1	3	2	7	2	5	1	1	1	1	1	1	5	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:13841896G>C	uc003jfd.2	-	33	5431	c.5389C>G	c.(5389-5391)CAG>GAG	p.Q1797E		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1797	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AATGAGGACTGAGATTCTTCC	0.438									Kartagener_syndrome				7	50					0	0	0	0	C	13841896	C	C	13841896	3	2	153	1	0	0	0	0	1	0	0	0	4626	1299	45	2	8673	2	DNAH5	5	13841896	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		13841896	167073364	73	27698											
DNAH5	1767	broad.mit.edu	37	chr5	13883188	13883188	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactgttctgcttcatgttaGaggcactgttactgtctgag	8	15	10	8	0	3	2	1	1	2	1	3	2	3	2	0	1	3	5	0	1	3	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:13883188G>A	uc003jfd.2	-	20	3041	c.2999C>T	c.(2998-3000)TCT>TTT	p.S1000F		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1000	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTCATGTTAGAGGCACTGTT	0.378									Kartagener_syndrome				13	92					0	0	0	0	A	13883188	A	A	13883188	3	1	153	1	0	0	0	0	1	0	0	0	4626	942	33	2	11115	2	DNAH5	5	13883188	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	41292	13883188	167032072	74	27699											
LMBRD2	92255	broad.mit.edu	37	chr5	36122518	36122518	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgcttgttccaaaagaatCtgccattgtacttgagttcg	11	14	8	8	1	1	2	0	1	1	1	3	2	2	2	2	0	3	4	2	0	5	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:36122518C>A	uc003jkb.1	-	9	1399	c.984G>T	c.(982-984)CAG>CAT	p.Q328H		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	328	Cytoplasmic (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCAAAAGAATCTGCCATTGTA	0.408													4	40					0.00909568	0.00943256	1	0	A	36122518	A	A	36122518	3	1	153	1	0	0	0	0	1	0	0	0	8885	912	32	2	1143	2	LMBRD2	5	36122518	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	22239330	36122518	144792742	75	27700											
TTC33	23548	broad.mit.edu	37	chr5	40747077	40747077	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgctgggaagtgacctttGagaccttctcaccaattttc	9	13	8	11	0	1	2	1	2	1	1	3	4	1	3	3	1	1	1	3	1	2	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:40747077G>C	uc003jma.2	-	2	192	c.44C>G	c.(43-45)TCA>TGA	p.S15*	TTC33_uc011cpm.1_5'UTR|TTC33_uc010ivg.2_Nonsense_Mutation_p.S15*	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	15							binding			ovary(1)	1						AGTGACCTTTGAGACCTTCTC	0.388													6	46					0	0	0	0	C	40747077	C	C	40747077	4	2	153	1	0	0	0	0	0	1	0	0	16770	1294	45	2	760	2	TTC33	5	40747077	Nonsense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	4624559	40747077	140168183	76	27701											
C6	729	broad.mit.edu	37	chr5	41203191	41203191	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacaaagctcacacccaccTgtgtctgctctgggttccag	8	9	8	16	0	3	0	1	0	2	0	4	0	4	0	4	1	2	3	4	1	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:41203191T>C	uc003jmk.2	-	2	352	c.142A>G	c.(142-144)AGA>GGA	p.R48G	C6_uc003jml.1_Missense_Mutation_p.R48G	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	48	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CACACCCACCTGTGTCTGCTC	0.478													6	238					0	0	0	0	C	41203191	C	C	41203191	3	2	153	1	0	0	0	0	1	0	0	0	2325	1594	55	5	2730	5	C6	5	41203191	Missense_Mutation	SNP	T	TCGA-CR-7386-01A-11D-2012-08	456114	41203191	139712069	77	27702											
SEPP1	6414	broad.mit.edu	37	chr5	42808335	42808335	+	RNA	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	accattggagtttagcattgGatcttgatctcttatgctcc	8	16	8	9	0	2	1	0	1	2	0	4	3	3	3	2	2	2	3	2	2	2	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:42808335G>A	uc011cps.1	-	3		c.309C>T			SEPP1_uc011cpt.1_RNA|SEPP1_uc011cpu.1_RNA|SEPP1_uc011cpv.1_RNA|SEPP1_uc003jna.2_RNA			P49908	SEPP1_HUMAN	Homo sapiens cDNA FLJ37321 fis, clone BRAMY2018122.						response to oxidative stress	extracellular region	selenium binding				0						TTTAGCATTGGATCTTGATCT	0.502													6	37					0	0	0	0	A	42808335	A	A	42808335	1	1	153	0	1	0	0	0	0	0	0	0	14122	1174	41	2		2	SEPP1	5	42808335	RNA	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1605144	42808335	138106925	78	27703											
BTF3	689	broad.mit.edu	37	chr5	72798854	72798854	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgctgagacaaagcagctGacagaaatgctacccagcat	15	6	9	11	0	0	3	0	2	0	2	0	4	0	3	1	0	6	5	1	0	3	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:72798854G>C	uc003kcr.1	+	4	672	c.429G>C	c.(427-429)CTG>CTC	p.L143L	BTF3_uc003kcq.1_Silent_p.L99L|BTF3_uc003kcs.1_RNA|BTF3_uc003kct.1_RNA	NM_001037637	NP_001032726	P20290	BTF3_HUMAN	basic transcription factor 3 isoform A	143	NAC-A/B.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding				0		Lung NSC(167;0.00405)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;2.73e-54)		CAAAGCAGCTGACAGAAATGC	0.473													15	86					0	0	0	0	C	72798854	C	C	72798854	2	2	153	1	0	0	0	0	0	0	0	1	1556	1277	45	2		2	BTF3	5	72798854	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	29990519	72798854	108116406	79	27704											
REEP5	7905	broad.mit.edu	37	chr5	112256898	112256898	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaaatcctatcaggttgcaGaggagagaggctccataacc	13	7	10	11	0	1	2	1	0	0	2	3	4	3	3	4	3	2	3	4	3	3	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:112256898G>C	uc003kqe.1	-	2	318	c.174C>G	c.(172-174)CTC>CTG	p.L58L	REEP5_uc011cvw.1_Silent_p.L31L|REEP5_uc011cvx.1_RNA|REEP5_uc011cvy.1_Silent_p.L58L|REEP5_uc011cvz.1_RNA	NM_005669	NP_005660	Q00765	REEP5_HUMAN	receptor accessory protein 5	58						integral to membrane	protein binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		Epithelial(69;1.3e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.26e-08)|all cancers(49;3.56e-07)|Colorectal(14;0.00778)|COAD - Colon adenocarcinoma(37;0.013)		TCAGGTTGCAGAGGAGAGAGG	0.597													7	43					0	0	0	0	C	112256898	C	C	112256898	2	2	153	1	0	0	0	0	0	0	0	1	13273	929	33	2		2	REEP5	5	112256898	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	39458044	112256898	68658362	80	27705											
HSD17B4	3295	broad.mit.edu	37	chr5	118832266	118832266	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagtataattgaagttctGagtaaaatagattcagaagg	16	11	11	3	0	2	4	1	2	1	2	2	4	2	4	0	2	0	4	0	2	7	7			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:118832266G>C	uc003ksj.2	+	12	1020	c.897G>C	c.(895-897)CTG>CTC	p.L299L	HSD17B4_uc011cwg.1_Silent_p.L275L|HSD17B4_uc011cwh.1_Silent_p.L281L|HSD17B4_uc011cwi.1_Silent_p.L324L|HSD17B4_uc003ksk.3_Silent_p.L152L|HSD17B4_uc011cwj.1_Silent_p.L152L|HSD17B4_uc010jcn.1_Silent_p.L37L	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	299	(3R)-hydroxyacyl-CoA dehydrogenase.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	TTGAAGTTCTGAGTAAAATAG	0.333													8	115					0	0	0	0	C	118832266	C	C	118832266	2	2	153	1	0	0	0	0	0	0	0	1	7425	1277	45	2		2	HSD17B4	5	118832266	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	6575368	118832266	62082994	81	27706											
RAD50	10111	broad.mit.edu	37	chr5	131930643	131930643	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagagcagttgtccagttacGaagacaagctgtttgatgtt	12	12	11	6	1	0	3	0	1	0	2	1	4	1	3	1	0	3	6	1	0	4	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:131930643G>A	uc003kxi.2	+	12	2263	c.1876G>A	c.(1876-1878)GAA>AAA	p.E626K	RAD50_uc003kxh.2_Missense_Mutation_p.E487K	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	626					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCCAGTTACGAAGACAAGCT	0.338								Homologous_recombination					12	63					0	0	0	0	A	131930643	A	A	131930643	3	1	153	1	0	0	0	0	1	0	0	0	13049	1059	37	1	1922	1	RAD50	5	131930643	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	13098377	131930643	48984617	82	27707											
PCDHA2	56146	broad.mit.edu	37	chr5	140176795	140176795	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcgccgtggggagctggtCttactcgcagcagaggcggc	6	6	17	12	4	1	1	0	0	1	1	2	2	1	2	1	5	4	3	1	5	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:140176795C>T	uc003lhd.2	+	1	2352	c.2246C>T	c.(2245-2247)TCT>TTT	p.S749F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.S749F|PCDHA2_uc011czy.1_Missense_Mutation_p.S749F	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	749	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAGCTGGTCTTACTCGCAG	0.672													19	77					0	0	0	0	T	140176795	T	T	140176795	3	4	153	1	0	0	0	0	1	0	0	0	11578	913	32	2	2248	2	PCDHA2	5	140176795	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	8246152	140176795	40738465	83	27708											
PCDHA13	56136	broad.mit.edu	37	chr5	140263342	140263342	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcctactcgctggtggagCggcgggtgggcgagcgtgcg	3	8	19	11	6	1	0	0	0	1	0	3	2	1	1	1	5	4	1	1	5	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:140263342C>T	uc003lif.2	+	1	1489	c.1489C>T	c.(1489-1491)CGG>TGG	p.R497W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.R497W|PCDHA13_uc003lid.2_Missense_Mutation_p.R497W	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	497	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGTGGAGCGGCGGGTGGG	0.662													12	85					0	0	0	0	T	140263342	T	T	140263342	3	4	153	1	0	0	0	0	1	0	0	0	11577	759	27	1	1491	1	PCDHA13	5	140263342	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	86547	140263342	40651918	84	27709											
PCDHGB2	56103	broad.mit.edu	37	chr5	140741419	140741419	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctggggcctgatggctccGccctcttcgatatggtgcca	4	10	13	14	3	1	1	0	1	1	0	3	2	2	1	4	4	1	2	4	4	1	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:140741419G>A	uc003ljs.1	+	1	1717	c.1717G>A	c.(1717-1719)GCC>ACC	p.A573T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.A573T|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	573	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATGGCTCCGCCCTCTTCGA	0.667													12	54					0	0	0	0	A	140741419	A	A	140741419	3	1	153	1	0	0	0	0	1	0	0	0	11617	1087	38	1	1719	1	PCDHGB2	5	140741419	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	478077	140741419	40173841	85	27710											
PCDHGB5	56101	broad.mit.edu	37	chr5	140779485	140779485	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacgcagactcaggacacaaCgcctggctgtcctaccacgt	10	6	10	15	3	1	1	1	0	0	1	2	3	2	2	3	2	2	2	3	2	2	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:140779485C>T	uc003lkf.1	+	1	1791	c.1791C>T	c.(1789-1791)AAC>AAT	p.N597N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.N597N	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	597	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGACACAACGCCTGGCTGT	0.677													12	71					0	0	0	0	T	140779485	T	T	140779485	2	4	153	1	0	0	0	0	0	0	0	1	11620	535	19	1		1	PCDHGB5	5	140779485	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	38066	140779485	40135775	86	27711											
RELL2	285613	broad.mit.edu	37	chr5	141019745	141019745	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acccctcgtgcacttgaaggGaaccccagagcttctgcaga	10	7	10	14	1	1	3	0	1	1	2	2	4	1	4	4	1	4	3	4	1	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:141019745G>A	uc003lli.2	+	6	1610	c.762G>A	c.(760-762)GGG>GGA	p.G254G	RELL2_uc003llh.2_Silent_p.G254G|RELL2_uc003llg.2_Silent_p.G188G|RELL2_uc010jgf.2_Silent_p.G188G|FCHSD1_uc010jgg.2_3'UTR|FCHSD1_uc003llj.2_RNA|FCHSD1_uc003llk.2_3'UTR	NM_001130029	NP_001123501	Q8NC24	RELL2_HUMAN	RELT-like 2	254						integral to membrane|plasma membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACTTGAAGGGAACCCCAGAG	0.647													4	58					0	0	0	0	A	141019745	A	A	141019745	2	1	153	1	0	0	0	0	0	0	0	1	13284	1161	41	2		2	RELL2	5	141019745	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	240260	141019745	39895515	87	27712											
STK32A	202374	broad.mit.edu	37	chr5	146750271	146750271	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaaattgtacacacgtttGagacgactgttgtaacttac	13	12	9	7	2	0	1	0	1	0	1	0	4	0	2	0	1	3	4	0	1	4	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:146750271G>C	uc010jgn.1	+	9	995	c.715G>C	c.(715-717)GAG>CAG	p.E239Q	STK32A_uc003lom.2_Missense_Mutation_p.E239Q|STK32A_uc011dbw.1_Missense_Mutation_p.E239Q	NM_001112724	NP_001106195	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A isoform 1	239	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACACGTTTGAGACGACTGT	0.398													9	131					0	0	0	0	C	146750271	C	C	146750271	3	2	153	1	0	0	0	0	1	0	0	0	15363	1291	45	2	778	2	STK32A	5	146750271	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	5730526	146750271	34164989	88	27713											
GCNT2	2651	broad.mit.edu	37	chr6	10529667	10529667	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggctgacctgaactgcctgGaagaccttgtggcctctgaa	9	9	12	11	0	1	4	0	3	1	1	1	5	1	5	4	3	2	1	4	3	3	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:10529667G>A	uc010joo.2	+	3	1074	c.523G>A	c.(523-525)GAA>AAA	p.E175K	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Missense_Mutation_p.E174K|GCNT2_uc010jon.2_Missense_Mutation_p.E174K	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	175	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		GAACTGCCTGGAAGACCTTGT	0.507													21	39					0	0	0	0	A	10529667	A	A	10529667	3	1	153	1	0	0	0	0	1	0	0	0	6336	1175	41	2	525	2	GCNT2	6	10529667	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		10529667	160585400	89	27714											
OR2J3	442186	broad.mit.edu	37	chr6	29079743	29079743	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattttctaattggcctcatCtggaagtagttatctttgtg	8	18	9	6	0	4	0	1	0	3	0	4	2	4	1	1	2	0	2	1	2	4	7			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:29079743C>G	uc011dll.1	+	1	76	c.76C>G	c.(76-78)CTG>GTG	p.L26V		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	26	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTGGCCTCATCTGGAAGTAGT	0.383													33	109					0	0	0	0	G	29079743	G	G	29079743	3	3	153	1	0	0	0	0	1	0	0	0	11058	912	32	2	78	2	OR2J3	6	29079743	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	18550076	29079743	142035324	90	27715											
MDC1	9656	broad.mit.edu	37	chr6	30671732	30671732	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttaggttccaagggtgcaGagcaaggcttatggtcaatg	11	11	13	6	0	1	1	1	0	0	1	2	1	2	1	1	4	2	4	1	4	5	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:30671732G>C	uc003nrg.3	-	10	5668	c.5228C>G	c.(5227-5229)TCT>TGT	p.S1743C	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.S1350C	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1743	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CAAGGGTGCAGAGCAAGGCTT	0.562								Other_conserved_DNA_damage_response_genes					19	66					0	0	0	0	C	30671732	C	C	30671732	3	2	153	1	0	0	0	0	1	0	0	0	9456	942	33	2	1065	2	MDC1	6	30671732	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1591989	30671732	140443335	91	27716											
PSORS1C2	170680	broad.mit.edu	37	chr6	31106763	31106763	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcacctctggtgtgcaggCaaaggaccaggatccccagg	9	6	12	14	0	2	0	1	0	1	0	3	2	3	2	5	5	1	2	5	5	1	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:31106763C>A	uc003nso.3	-	1	365	c.41G>T	c.(40-42)TGC>TTC	p.C14F	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron|PSORS1C1_uc003nsn.1_Intron	NM_014069	NP_054788	Q9UIG4	PS1C2_HUMAN	SPR1 protein precursor	14						extracellular region					0						GGTGTGCAGGCAAAGGACCAG	0.597													10	51					0.00829132	0.00866257	1	0	A	31106763	A	A	31106763	3	1	153	1	0	0	0	0	1	0	0	0	12777	710	25	4	377	4	PSORS1C2	6	31106763	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	435031	31106763	140008304	92	27717											
MCCD1	401250	broad.mit.edu	37	chr6	31495806	31495811	+	5'Flank	DEL	AAAAAA	-	-																															acagagcgagactccgtctcAaaaaaaaaaaaaaaaaaaaa																								rs147277013		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:31495806_31495811delAAAAAA	uc003ntp.1	+							NM_001011700	NP_001011700	P59942	MCCD1_HUMAN	mitochondrial coiled-coil domain 1 precursor							mitochondrion					0						actccgtctcaaaaaaaaaaaaaaaa	0.204													---	---	---								-	31495811	-	-	31495806	6	5	153	0	1	1	0	1	0	0	0	0	9429	145	5	0		0	MCCD1	6	31495806	5'Flank	DEL	AAAAAA	TCGA-CR-7386-01A-11D-2012-08	389043	31495806	139619261	93	27718											
DST	667	broad.mit.edu	37	chr6	56374648	56374648	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgcgttccaggctctcaagGatctgatctatcttgtcatg	8	14	9	10	1	5	1	2	1	4	0	7	2	6	2	1	2	1	2	1	2	2	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:56374648G>A	uc003pdf.2	-	68	12475	c.12447C>T	c.(12445-12447)ATC>ATT	p.I4149I	DST_uc003pcz.3_Silent_p.I3971I|DST_uc011dxj.1_Silent_p.I4000I|DST_uc011dxk.1_Silent_p.I4011I|DST_uc003pcy.3_Silent_p.I3645I	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6057	Spectrin 12.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GGCTCTCAAGGATCTGATCTA	0.398													5	45					0	0	0	0	A	56374648	A	A	56374648	2	1	153	1	0	0	0	0	0	0	0	1	4805	1164	41	2		2	DST	6	56374648	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	24878842	56374648	114740419	94	27719											
DOPEY1	23033	broad.mit.edu	37	chr6	83810518	83810518	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acatccagcattaccaggtgGagttcatcggaaggcgcttg	10	9	12	10	2	1	0	1	0	0	0	3	2	2	2	2	4	2	3	2	4	2	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:83810518G>C	uc003pjs.1	+	4	493	c.233G>C	c.(232-234)GGA>GCA	p.G78A	DOPEY1_uc011dyy.1_Missense_Mutation_p.G78A|DOPEY1_uc010kbl.1_Missense_Mutation_p.G78A	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	78					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTACCAGGTGGAGTTCATCGG	0.363													26	181					0	0	0	0	C	83810518	C	C	83810518	3	2	153	1	0	0	0	0	1	0	0	0	4729	1174	41	2	239	2	DOPEY1	6	83810518	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	27435870	83810518	87304549	95	27720											
RARS2	57038	broad.mit.edu	37	chr6	88251661	88251661	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agagatgctgtagaggattgGactgcagtttttcctcatag	10	13	12	6	0	1	2	1	0	0	2	2	5	2	4	1	2	2	4	1	2	2	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:88251661G>C	uc003pme.2	-	8	647	c.587C>G	c.(586-588)TCC>TGC	p.S196C	RARS2_uc003pmb.2_Missense_Mutation_p.S21C|RARS2_uc003pmc.2_Missense_Mutation_p.S21C|RARS2_uc003pmd.2_5'UTR|RARS2_uc003pmf.2_RNA	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	196					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		TAGAGGATTGGACTGCAGTTT	0.363													4	26					0	0	0	0	C	88251661	C	C	88251661	3	2	153	1	0	0	0	0	1	0	0	0	13124	1174	41	2	1201	2	RARS2	6	88251661	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	4441143	88251661	82863406	96	27721											
REV3L	5980	broad.mit.edu	37	chr6	111696128	111696128	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaagcattgcctctttttCtgcagcagccatgatttctt	10	15	6	10	0	3	1	0	1	3	0	3	1	3	1	2	0	5	3	2	0	2	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:111696128C>T	uc003puy.3	-	13	3753	c.3430G>A	c.(3430-3432)GAA>AAA	p.E1144K	REV3L_uc003pux.3_Missense_Mutation_p.E1066K|REV3L_uc003puz.3_Missense_Mutation_p.E1066K	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1144					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GCCTCTTTTTCTGCAGCAGCC	0.418								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					15	117					0	0	0	0	T	111696128	T	T	111696128	3	4	153	1	0	0	0	0	1	0	0	0	13305	922	32	2	6042	2	REV3L	6	111696128	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	23444467	111696128	59418939	97	27722											
LAMA2	3908	broad.mit.edu	37	chr6	129714246	129714246	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttggagagtcccggggggAaaatgaagaaatggagaagg	14	6	18	3	1	0	4	0	1	0	3	1	7	1	5	1	6	0	1	1	6	5	1	rs141950826		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:129714246A>G	uc003qbn.2	+	37	5396	c.5291A>G	c.(5290-5292)GAA>GGA	p.E1764G	LAMA2_uc003qbo.2_Missense_Mutation_p.E1764G	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1764	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCCCGGGGGGAAAATGAAGAA	0.453													3	73					0	0	0	0	G	129714246	G	G	129714246	3	3	153	1	0	0	0	0	1	0	0	0	8646	246	9	5	5437	5	LAMA2	6	129714246	Missense_Mutation	SNP	A	TCGA-CR-7386-01A-11D-2012-08	18018118	129714246	41400821	98	27723											
SYNE1	23345	broad.mit.edu	37	chr6	152557387	152557387	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaagtcgtttcccatcatCtaatacttgatataatttgg	12	15	6	8	1	2	2	1	1	1	1	4	2	3	2	1	1	1	1	1	1	5	7			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:152557387C>G	uc010kiw.2	-	110	20853	c.20251G>C	c.(20251-20253)GAT>CAT	p.D6751H	SYNE1_uc010kiv.2_Missense_Mutation_p.D1275H|SYNE1_uc003qos.3_Missense_Mutation_p.D1275H|SYNE1_uc003qot.3_Missense_Mutation_p.D6680H|SYNE1_uc003qou.3_Missense_Mutation_p.D6751H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6751	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCCCATCATCTAATACTTGA	0.328										HNSCC(10;0.0054)			5	50					0	0	0	0	G	152557387	G	G	152557387	3	3	153	1	0	0	0	0	1	0	0	0	15511	913	32	2	6363	2	SYNE1	6	152557387	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	22843141	152557387	18557680	99	27724											
CCR6	1235	broad.mit.edu	37	chr6	167550802	167550802	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatttctcggcagaccagtGagaccgcagataacgacaat	14	7	9	11	3	1	3	0	1	1	3	2	5	1	3	2	1	1	2	2	1	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:167550802G>A	uc003qvl.2	+	13	3560	c.1084G>A	c.(1084-1086)GAG>AAG	p.E362K	CCR6_uc010kkm.2_Missense_Mutation_p.E362K|CCR6_uc003qvn.3_Missense_Mutation_p.E362K|CCR6_uc003qvm.3_Missense_Mutation_p.E362K	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	362	Cytoplasmic (Potential).				cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		GCAGACCAGTGAGACCGCAGA	0.438													5	52					0	0	0	0	A	167550802	A	A	167550802	3	1	153	1	0	0	0	0	1	0	0	0	2960	1291	45	2	1090	2	CCR6	6	167550802	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	14993415	167550802	3564265	100	27725											
CCDC129	223075	broad.mit.edu	37	chr7	31683300	31683300	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctctaagcaacaagaccttGacacatgggccccagcccct	11	6	8	16	0	1	2	0	1	1	1	1	2	1	2	5	1	3	2	5	1	3	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:31683300G>A	uc003tcj.1	+	11	3309	c.2316G>A	c.(2314-2316)TTG>TTA	p.L772L	CCDC129_uc011kad.1_Silent_p.L782L|CCDC129_uc003tci.1_Silent_p.L623L|CCDC129_uc011kae.1_Silent_p.L798L|CCDC129_uc003tck.1_Silent_p.L680L	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	772											0						ACAAGACCTTGACACATGGGC	0.502													17	79					0	0	0	0	A	31683300	A	A	31683300	2	1	153	1	0	0	0	0	0	0	0	1	2776	1281	45	2		2	CCDC129	7	31683300	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08		31683300	127455363	101	27726											
HECW1	23072	broad.mit.edu	37	chr7	43531746	43531746	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acagcttagtagctgctattCgaagccaacatcaacatgag	14	9	8	10	1	1	1	1	1	0	0	2	2	1	1	1	0	6	4	1	0	6	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:43531746C>G	uc003tid.1	+	18	3912	c.3307C>G	c.(3307-3309)CGA>GGA	p.R1103G	HECW1_uc011kbi.1_Missense_Mutation_p.R1069G	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1103					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity	p.R1103H(1)		ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGCTGCTATTCGAAGCCAACA	0.423													9	73					0	0	0	0	G	43531746	G	G	43531746	3	3	153	1	0	0	0	0	1	0	0	0	7081	876	31	3	3369	3	HECW1	7	43531746	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	11848446	43531746	115606917	102	27727											
C7orf57	136288	broad.mit.edu	37	chr7	48092304	48092304	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactctttttaaggcctggtCaaaaaaacagttcacctacc	13	12	5	11	0	3	0	2	0	1	0	3	0	3	0	3	2	3	1	3	2	6	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:48092304C>G	uc003toh.3	+	7	825	c.613C>G	c.(613-615)CAA>GAA	p.Q205E	C7orf57_uc003toi.3_Intron	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	205										ovary(1)	1						AAGGCCTGGTCAAAAAAACAG	0.408													5	99					0	0	0	0	G	48092304	G	G	48092304	3	3	153	1	0	0	0	0	1	0	0	0	2415	827	29	2	635	2	C7orf57	7	48092304	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	4560558	48092304	111046359	103	27728											
FIGNL1	63979	broad.mit.edu	37	chr7	50513306	50513306	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggggaatataaagccttttCaccaatcttctccgggcagc	11	10	9	11	1	3	0	1	0	2	0	4	1	3	1	3	3	2	1	3	3	5	5	rs143012740		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:50513306C>T	uc003tpc.2	-	4	2057	c.1680G>A	c.(1678-1680)GTG>GTA	p.V560V	FIGNL1_uc003tpb.2_Silent_p.V449V|FIGNL1_uc003tpd.2_Silent_p.V560V|FIGNL1_uc003tpe.2_Silent_p.V560V|FIGNL1_uc010kyy.2_Silent_p.V560V	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	560					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				AAAGCCTTTTCACCAATCTTC	0.433													4	92					0	0	0	0	T	50513306	T	T	50513306	2	4	153	1	0	0	0	0	0	0	0	1	5924	813	29	2		2	FIGNL1	7	50513306	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	2421002	50513306	108625357	104	27729											
CCDC146	57639	broad.mit.edu	37	chr7	76924175	76924175	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacctgttataaagccagttGaaatctgaatatgtgaacaa	17	11	7	6	0	1	3	0	3	1	0	1	3	1	3	2	0	3	2	2	0	9	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:76924175G>C	uc003uga.2	+	19	2987	c.2860G>C	c.(2860-2862)GAA>CAA	p.E954Q	CCDC146_uc010ldp.2_Missense_Mutation_p.E668Q|CCDC146_uc003ugc.2_Missense_Mutation_p.E291Q	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	954										ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				AAAGCCAGTTGAAATCTGAAT	0.413													4	27					0	0	0	0	C	76924175	C	C	76924175	3	2	153	1	0	0	0	0	1	0	0	0	2792	1291	45	2	2930	2	CCDC146	7	76924175	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	26410869	76924175	82214488	105	27730											
GRM3	2913	broad.mit.edu	37	chr7	86468876	86468876	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgctcagaggccaaaattCatcagccccagttctcaggt	10	8	10	13	1	4	1	4	0	1	1	5	1	4	1	3	3	1	2	3	3	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:86468876C>A	uc003uid.2	+	4	3145	c.2046C>A	c.(2044-2046)TTC>TTA	p.F682L	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.F554L|GRM3_uc010leh.2_Missense_Mutation_p.F274L	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	682	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGCCAAAATTCATCAGCCCCA	0.542													18	71					2.35188e-11	2.57237e-11	1	0	A	86468876	A	A	86468876	3	1	153	1	0	0	0	0	1	0	0	0	6837	825	29	2	2056	2	GRM3	7	86468876	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	9544701	86468876	72669787	106	27731											
C7orf63	79846	broad.mit.edu	37	chr7	89939442	89939442	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccgattagtaggaggacctCtggttgatacggatattgct	9	12	12	8	2	1	1	0	1	1	0	1	5	1	4	2	4	2	3	2	4	4	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:89939442C>T	uc010lep.2	+	23	2967	c.2716C>T	c.(2716-2718)CTG>TTG	p.L906L	C7orf63_uc011khj.1_Silent_p.L888L|C7orf63_uc011khk.1_Silent_p.L422L	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	906							binding			ovary(1)	1						AGGAGGACCTCTGGTTGATAC	0.433													6	74					0	0	0	0	T	89939442	T	T	89939442	2	4	153	1	0	0	0	0	0	0	0	1	2420	912	32	2		2	C7orf63	7	89939442	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	3470566	89939442	69199221	107	27732											
HBP1	26959	broad.mit.edu	37	chr7	106826264	106826264	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatcatctcctgtacacatCatagccactagcaaaagttt	14	11	5	11	0	3	1	2	0	1	1	4	1	3	1	2	0	3	3	2	0	5	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:106826264C>T	uc003vdy.2	+	4	603	c.417C>T	c.(415-417)ATC>ATT	p.I139I	HBP1_uc011klv.1_Silent_p.I149I|HBP1_uc003vdz.2_Silent_p.I139I|HBP1_uc003vea.2_Silent_p.I139I|HBP1_uc003veb.1_Silent_p.I139I	NM_012257	NP_036389	O60381	HBP1_HUMAN	HMG-box transcription factor 1	139					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			skin(1)	1						CTGTACACATCATAGCCACTA	0.403													18	133					0	0	0	0	T	106826264	T	T	106826264	2	4	153	1	0	0	0	0	0	0	0	1	7024	816	29	2		2	HBP1	7	106826264	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	16886822	106826264	52312399	108	27733											
RBM28	55131	broad.mit.edu	37	chr7	127961459	127961459	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attctggtccttgagtttctGatgcttcagcagctcaaact	8	15	8	10	0	4	2	2	2	2	0	5	2	5	2	1	1	4	4	1	1	1	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:127961459G>C	uc003vmp.2	-	14	1538	c.1423C>G	c.(1423-1425)CAG>GAG	p.Q475E	RBM28_uc003vmo.2_Missense_Mutation_p.Q92E|RBM28_uc011koj.1_Missense_Mutation_p.Q334E	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	475					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						TTGAGTTTCTGATGCTTCAGC	0.433													6	47					0	0	0	0	C	127961459	C	C	127961459	3	2	153	1	0	0	0	0	1	0	0	0	13193	1299	45	2	880	2	RBM28	7	127961459	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	21135195	127961459	31177204	109	27734											
CNTNAP2	26047	broad.mit.edu	37	chr7	146536831	146536831	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggatggtctccatcagacagCgaccattatcaatggcttca	11	10	9	11	1	4	1	3	0	1	1	5	3	4	2	2	3	1	1	2	3	2	2	rs145162968		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:146536831C>T	uc003weu.1	+	3	753	c.237C>T	c.(235-237)AGC>AGT	p.S79S		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	79	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CATCAGACAGCGACCATTATC	0.448										HNSCC(39;0.1)			11	54					0	0	0	0	T	146536831	T	T	146536831	2	4	153	1	0	0	0	0	0	0	0	1	3662	767	27	1		1	CNTNAP2	7	146536831	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	18575372	146536831	12601832	110	27735											
CNTNAP2	26047	broad.mit.edu	37	chr7	147869376	147869376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttcctgggctgcatccgctCcttgaggatgaatggggtga	6	11	14	10	1	0	3	0	3	0	0	3	4	3	4	3	4	1	3	3	4	1	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:147869376C>T	uc003weu.1	+	18	3332	c.2816C>T	c.(2815-2817)TCC>TTC	p.S939F		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	939	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGCATCCGCTCCTTGAGGATG	0.542										HNSCC(39;0.1)			10	65					0	0	0	0	T	147869376	T	T	147869376	3	4	153	1	0	0	0	0	1	0	0	0	3662	855	30	2	2886	2	CNTNAP2	7	147869376	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	1332545	147869376	11269287	111	27736											
PIWIL2	55124	broad.mit.edu	37	chr8	22167484	22167484	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtttagattgaaggacGtgttctgccaatggaaagaa	12	13	11	5	1	2	3	0	1	2	2	2	5	2	5	1	2	1	2	1	2	5	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:22167484G>A	uc003xbn.2	+	15	1845	c.1697G>A	c.(1696-1698)CGT>CAT	p.R566H	PIWIL2_uc011kzf.1_Missense_Mutation_p.R566H|PIWIL2_uc010ltv.2_Missense_Mutation_p.R566H	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	566					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		ATTGAAGGACGTGTTCTGCCA	0.383													6	49					0	0	0	0	A	22167484	A	A	22167484	3	1	153	1	0	0	0	0	1	0	0	0	12013	1145	40	1	1751	1	PIWIL2	8	22167484	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		22167484	124196538	112	27737											
PLAT	5327	broad.mit.edu	37	chr8	42038171	42038171	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctcctttgatgcgaaactGaggctggctgtactgtctca	7	12	10	12	1	1	2	1	2	1	0	3	3	2	2	2	2	3	3	2	2	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:42038171G>A	uc003xos.2	-	10	1131	c.922C>T	c.(922-924)CAG>TAG	p.Q308*	PLAT_uc010lxf.1_Nonsense_Mutation_p.Q225*|PLAT_uc010lxg.1_Nonsense_Mutation_p.Q133*|PLAT_uc003xot.2_Nonsense_Mutation_p.Q262*|PLAT_uc011lcm.1_Nonsense_Mutation_p.Q219*|PLAT_uc011lcn.1_Nonsense_Mutation_p.Q182*	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	308					blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATGCGAAACTGAGGCTGGCTG	0.632													8	35					0	0	0	0	A	42038171	A	A	42038171	4	1	153	1	0	0	0	0	0	1	0	0	12076	1299	45	2	786	2	PLAT	8	42038171	Nonsense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	19870687	42038171	104325851	113	27738											
PRKDC	5591	broad.mit.edu	37	chr8	48842538	48842538	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgagtacacccatggttCaaaaaattctgcttgtttct	13	14	6	8	0	3	1	1	1	2	0	3	1	3	1	1	1	2	4	1	1	5	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:48842538C>A	uc003xqi.2	-	18	1984	c.1927G>T	c.(1927-1929)GAA>TAA	p.E643*	PRKDC_uc003xqj.2_Nonsense_Mutation_p.E643*|PRKDC_uc011ldh.1_Nonsense_Mutation_p.E643*	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	643					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACCCATGGTTCAAAAAATTCT	0.318								NHEJ					5	80					5.9392e-07	6.42076e-07	1	0	A	48842538	A	A	48842538	4	1	153	1	0	0	0	0	0	1	0	0	12583	835	29	2	10734	2	PRKDC	8	48842538	Nonsense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	6804367	48842538	97521484	114	27739											
RGS20	8601	broad.mit.edu	37	chr8	54866838	54866838	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaagcaaggataatctatGaagactacatttctatactt	17	12	6	6	0	2	3	0	1	2	2	2	4	2	4	0	1	3	1	0	1	8	7			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:54866838G>A	uc003xrp.2	+	5	1038	c.946G>A	c.(946-948)GAA>AAA	p.E316K	RGS20_uc003xrq.2_Missense_Mutation_p.E201K|RGS20_uc010lye.2_Missense_Mutation_p.E108K|RGS20_uc010lyf.2_Missense_Mutation_p.E80K|RGS20_uc003xrs.2_Missense_Mutation_p.E169K|RGS20_uc003xrt.2_Missense_Mutation_p.E50K	NM_170587	NP_733466	O76081	RGS20_HUMAN	regulator of G-protein signaling 20 isoform a	316	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			GATAATCTATGAAGACTACAT	0.378													6	47					0	0	0	0	A	54866838	A	A	54866838	3	1	153	1	0	0	0	0	1	0	0	0	13368	1291	45	2	1037	2	RGS20	8	54866838	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	6024300	54866838	91497184	115	27740											
RUNX1T1	862	broad.mit.edu	37	chr8	92972554	92972554	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtggtgtgtccatcgggctCccagccccgctgttgggcgt	2	10	16	13	3	0	0	0	0	0	0	3	0	2	0	4	4	1	3	4	4	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:92972554C>T	uc003yfd.2	-	11	1815	c.1731G>A	c.(1729-1731)GGG>GGA	p.G577G	RUNX1T1_uc003yfc.1_Silent_p.G550G|RUNX1T1_uc003yfe.1_Silent_p.G540G|RUNX1T1_uc010mao.2_Silent_p.G550G|RUNX1T1_uc011lgi.1_Silent_p.G588G|uc010mam.2_5'Flank|RUNX1T1_uc010man.1_Silent_p.G202G|RUNX1T1_uc003yfb.1_Silent_p.G540G	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	577					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CCATCGGGCTCCCAGCCCCGC	0.622													8	39					0	0	0	0	T	92972554	T	T	92972554	2	4	153	1	0	0	0	0	0	0	0	1	13812	842	30	2		2	RUNX1T1	8	92972554	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	38105716	92972554	53391468	116	27741											
HAS2	3037	broad.mit.edu	37	chr8	122626424	122626424	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgatgagaactacatacagCgtcaaaagcatgacccaata	17	8	7	9	1	1	3	1	3	0	1	1	4	1	3	1	0	5	1	1	0	7	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:122626424C>T	uc003yph.2	-	4	2122	c.1584G>A	c.(1582-1584)ACG>ACA	p.T528T		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	528	Helical; Name=7; (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			CTACATACAGCGTCAAAAGCA	0.408													14	84					0	0	0	0	T	122626424	T	T	122626424	2	4	153	1	0	0	0	0	0	0	0	1	7001	755	27	1		1	HAS2	8	122626424	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	29653870	122626424	23737598	117	27742											
PUF60	22827	broad.mit.edu	37	chr8	144899260	144899260	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggctggccaggatggggttCaccactcccaccgaggggat	7	6	16	12	1	1	0	1	0	0	0	2	3	2	2	4	7	0	2	4	7	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:144899260C>T	uc003yzs.2	-	11	1264	c.1200G>A	c.(1198-1200)GTG>GTA	p.V400V	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Silent_p.V340V|PUF60_uc003yzt.2_Silent_p.V383V|PUF60_uc003yzq.2_Silent_p.V357V|PUF60_uc003yzu.1_Silent_p.V389V	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	400	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGATGGGGTTCACCACTCCCA	0.622													3	25					0	0	0	0	T	144899260	T	T	144899260	2	4	153	1	0	0	0	0	0	0	0	1	12889	813	29	2		2	PUF60	8	144899260	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	22272836	144899260	1464762	118	27743											
KIAA2026	158358	broad.mit.edu	37	chr9	5921788	5921788	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgatggtagtagagtactaGaacaaatagaggacttcaag	16	10	11	4	0	1	4	1	1	0	3	1	5	1	5	0	2	2	3	0	2	8	7			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr9:5921788G>C	uc003zjq.3	-	8	4424	c.4208C>G	c.(4207-4209)TCT>TGT	p.S1403C	KIAA2026_uc010mht.2_Missense_Mutation_p.S578C	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1403	Ser-rich.									ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TAGAGTACTAGAACAAATAGA	0.393													15	92					0	0	0	0	C	5921788	C	C	5921788	3	2	153	1	0	0	0	0	1	0	0	0	8309	942	33	2	2107	2	KIAA2026	9	5921788	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		5921788	135291643	119	27744											
CDKN2A	1029	broad.mit.edu	37	chr9	21971028	21971028	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggtccacgggcagacggccCcaggcatcgcgcacgtccag	8	3	14	16	5	0	1	0	0	0	1	3	1	2	1	4	4	0	3	4	4	0	0	rs121913389		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr9:21971028C>T	uc003zpk.2	-	2	542	c.330G>A	c.(328-330)TGG>TGA	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.G166R	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGACGGCCCCAGGCATCGC	0.736		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	23					0	0	0	0	T	21971028	T	T	21971028	4	4	153	1	0	0	0	0	0	1	0	0	3176	624	22	4	148	4	CDKN2A	9	21971028	Nonsense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	16049240	21971028	119242403	120	27745											
TLN1	7094	broad.mit.edu	37	chr9	35698089	35698089	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaccaccactgtctcattCtcctgctcttcaaaggctgc	7	13	5	16	0	5	0	3	0	3	0	7	0	5	0	3	1	2	2	3	1	1	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr9:35698089C>G	uc003zxt.2	-	56	7806	c.7452G>C	c.(7450-7452)GAG>GAC	p.E2484D		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	2484	I/LWEQ.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTGTCTCATTCTCCTGCTCTT	0.562													15	93					0	0	0	0	G	35698089	G	G	35698089	3	3	153	1	0	0	0	0	1	0	0	0	16013	912	32	2	181	2	TLN1	9	35698089	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	13727061	35698089	105515342	121	27746											
KIAA1958	158405	broad.mit.edu	37	chr9	115422154	115422154	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggaggccaagtcccccttCtacctgactgccaggaagga	10	7	11	13	0	1	1	0	1	1	0	2	4	2	4	5	4	2	0	5	4	3	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr9:115422154C>T	uc004bgf.1	+	4	2131	c.1956C>T	c.(1954-1956)TTC>TTT	p.F652F	KIAA1958_uc011lwx.1_Silent_p.F680F	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	652										skin(1)	1						AGTCCCCCTTCTACCTGACTG	0.577													6	35					0	0	0	0	T	115422154	T	T	115422154	2	4	153	1	0	0	0	0	0	0	0	1	8303	912	32	2		2	KIAA1958	9	115422154	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	79724065	115422154	25791277	122	27747											
LCN6	158062	broad.mit.edu	37	chr9	139639631	139639631	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agcacacttactgtacagctCcacggtgttgaagggctcgt	9	10	11	11	2	0	1	0	1	0	0	2	1	1	1	1	2	4	5	1	2	3	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr9:139639631C>T	uc004ciy.2	-	4	448	c.403G>A	c.(403-405)GAG>AAG	p.E135K	LCN10_uc004civ.2_5'Flank|LCN10_uc011med.1_5'Flank|LCN10_uc010nbq.2_5'Flank|LCN10_uc011mee.1_5'Flank|LCN10_uc011mef.1_5'Flank|LCN10_uc004ciw.2_RNA|uc004ciz.1_5'Flank	NM_198946	NP_945184	P62502	LCN6_HUMAN	lipocalin 6 precursor	135					single fertilization	extracellular region	binding				0	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.32e-06)|Epithelial(140;7.83e-05)		CTGTACAGCTCCACGGTGTTG	0.627													10	51					0	0	0	0	T	139639631	T	T	139639631	3	4	153	1	0	0	0	0	1	0	0	0	8725	864	30	2	96	2	LCN6	9	139639631	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	24217477	139639631	1573800	123	27748											
CUBN	8029	broad.mit.edu	37	chr10	17164832	17164832	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaacacatgtgcctccattCtggcagctcaagggtgttcc	8	12	9	12	0	2	0	1	0	1	0	4	0	4	0	3	2	3	3	3	2	2	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:17164832C>G	uc001ioo.2	-	6	607	c.555G>C	c.(553-555)CAG>CAC	p.Q185H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	185	EGF-like 2; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGCCTCCATTCTGGCAGCTCA	0.383													12	45					0	0	0	0	G	17164832	G	G	17164832	3	3	153	1	0	0	0	0	1	0	0	0	4068	912	32	2	10564	2	CUBN	10	17164832	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08		17164832	118369915	124	27749											
KIAA1462	57608	broad.mit.edu	37	chr10	30317105	30317105	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggtcatttgtttgtctgtCttcttctggttcccctagat	4	19	9	9	0	5	1	1	0	4	1	6	2	6	1	2	2	0	2	2	2	1	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:30317105C>G	uc001iux.2	-	2	2031	c.1972G>C	c.(1972-1974)GAC>CAC	p.D658H	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.D520H|KIAA1462_uc009xle.1_Missense_Mutation_p.D658H	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	658										ovary(4)	4						GTTTGTCTGTCTTCTTCTGGT	0.517													8	51					0	0	0	0	G	30317105	G	G	30317105	3	3	153	1	0	0	0	0	1	0	0	0	8273	913	32	2	2115	2	KIAA1462	10	30317105	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	13152273	30317105	105217642	125	27750											
MTPAP	55149	broad.mit.edu	37	chr10	30653930	30653932	+	In_Frame_Del	DEL	TCC	-	-																															cctgggccagcctgatgatgTcctcctcctcctggtgccgc																										TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:30653930_30653932delTCC	uc001ivb.3	-	9	1622_1624	c.250_252delGGA	c.(250-252)GGAdel	p.G84del	LOC729668_uc001ivd.2_RNA|uc001ive.1_RNA|uc001ivg.1_5'Flank	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor	Error:Variant_position_missing_in_Q9NVV4_after_alignment					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						CCTGATGATGTCCTCCTCCTCCT	0.507													---	---	---								-	30653932	-	-	30653930	7	5	153	1	0	1	0	1	0	0	0	0	10009	1682	58	0		0	MTPAP	10	30653930	In_Frame_Del	DEL	TCC	TCGA-CR-7386-01A-11D-2012-08	336825	30653930	104880817	126	27751											
GRID1	2894	broad.mit.edu	37	chr10	87487785	87487785	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggctgtcctaggatgttctCagccaccatcacgaaaggct	9	9	11	12	1	2	0	2	0	1	0	4	2	3	1	3	3	1	3	3	3	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:87487785C>G	uc001kdl.1	-	10	1461	c.1360G>C	c.(1360-1362)GAG>CAG	p.E454Q	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.E25Q	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	454	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGGATGTTCTCAGCCACCATC	0.448										Multiple Myeloma(13;0.14)			17	156					0	0	0	0	G	87487785	G	G	87487785	3	3	153	1	0	0	0	0	1	0	0	0	6810	835	29	2	1697	2	GRID1	10	87487785	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	56833855	87487785	48046962	127	27752											
FAM35A	54537	broad.mit.edu	37	chr10	88946848	88946848	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttactcttttgtaggccagcGttaatgactgccattgatgg	8	15	10	8	1	1	2	0	2	1	0	1	2	1	2	2	2	3	2	2	2	3	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:88946848G>A	uc001kei.3	+	8	2313	c.2199G>A	c.(2197-2199)GCG>GCA	p.A733A	FAM35A_uc001kej.3_Silent_p.A179A	NM_019054	NP_061927	Q86V20	FA35A_HUMAN	hypothetical protein LOC54537	733										ovary(2)|skin(2)	4						GTAGGCCAGCGTTAATGACTG	0.353													4	44					0	0	0	0	A	88946848	A	A	88946848	2	1	153	1	0	0	0	0	0	0	0	1	5585	1132	40	1		1	FAM35A	10	88946848	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1459063	88946848	46587899	128	27753											
SH3PXD2A	9644	broad.mit.edu	37	chr10	105362900	105362900	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgttgatggtgatggatGaggaaaaggaggctgaggag	11	9	20	1	0	0	4	0	4	0	0	0	8	0	8	0	7	0	2	0	7	2	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:105362900G>C	uc001kxj.1	-	14	2131	c.1991C>G	c.(1990-1992)TCA>TGA	p.S664*	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Nonsense_Mutation_p.S499*|SH3PXD2A_uc010qqt.1_Nonsense_Mutation_p.S541*|SH3PXD2A_uc009xxn.1_Nonsense_Mutation_p.S499*|SH3PXD2A_uc010qqu.1_Nonsense_Mutation_p.S607*	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	692	Ser-rich.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		GGTGATGGATGAGGAAAAGGA	0.458													26	144					0	0	0	0	C	105362900	C	C	105362900	4	2	153	1	0	0	0	0	0	1	0	0	14321	1294	45	2	1330	2	SH3PXD2A	10	105362900	Nonsense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	16416052	105362900	30171847	129	27754											
COL17A1	1308	broad.mit.edu	37	chr10	105814753	105814753	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattacctttagggcctggaCttcccatgtcacctgaaacc	10	11	7	13	0	1	1	1	1	0	0	2	2	2	2	5	2	2	0	5	2	4	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:105814753C>G	uc001kxr.2	-	20	1899	c.1730G>C	c.(1729-1731)AGT>ACT	p.S577T	COL17A1_uc010qqv.1_Missense_Mutation_p.S561T	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	577	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGGGCCTGGACTTCCCATGTC	0.383													3	26					0	0	0	0	G	105814753	G	G	105814753	3	3	153	1	0	0	0	0	1	0	0	0	3689	565	20	4	2911	4	COL17A1	10	105814753	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	451853	105814753	29719994	130	27755											
BTBD16	118663	broad.mit.edu	37	chr10	124097537	124097537	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttttcatgttttagaccttGaaaatccaaactgtgggcat	11	16	7	7	0	1	2	1	1	0	1	2	2	2	2	2	1	1	2	2	1	4	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:124097537G>C	uc001lgc.1	+	16	1709	c.1458G>C	c.(1456-1458)TTG>TTC	p.L486F	BTBD16_uc001lgd.1_Missense_Mutation_p.L485F	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	486										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				TTTAGACCTTGAAAATCCAAA	0.403													6	38					0	0	0	0	C	124097537	C	C	124097537	3	2	153	1	0	0	0	0	1	0	0	0	1546	1281	45	2	1516	2	BTBD16	10	124097537	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	18282784	124097537	11437210	131	27756											
DUSP8	1850	broad.mit.edu	37	chr11	1579116	1579116	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgccagccagacagtggacGatgacttggcagctggagag	11	6	15	9	1	0	3	0	1	0	2	0	6	0	4	2	3	3	2	2	3	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:1579116G>A	uc001lts.2	-	6	857	c.729C>T	c.(727-729)ATC>ATT	p.I243I		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	243	Tyrosine-protein phosphatase.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		GACAGTGGACGATGACTTGGC	0.617													13	60					0	0	0	0	A	1579116	A	A	1579116	2	1	153	1	0	0	0	0	0	0	0	1	4853	1048	37	1		1	DUSP8	11	1579116	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08		1579116	133427400	132	27757											
TRIM68	55128	broad.mit.edu	37	chr11	4622349	4622349	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggctgctgcaagctccaaGatttgctcctggtagaggag	8	10	13	10	0	0	2	0	0	0	2	2	3	2	3	2	3	4	6	2	3	3	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:4622349G>C	uc001lzf.1	-	6	1053	c.815C>G	c.(814-816)TCT>TGT	p.S272C	TRIM68_uc001lzg.1_Missense_Mutation_p.S49C|TRIM68_uc010qyj.1_Intron	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	272					protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CAAGCTCCAAGATTTGCTCCT	0.547													12	95					0	0	0	0	C	4622349	C	C	4622349	3	2	153	1	0	0	0	0	1	0	0	0	16608	942	33	2	650	2	TRIM68	11	4622349	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	3043233	4622349	130384167	133	27758											
OR52E2	119678	broad.mit.edu	37	chr11	5080352	5080352	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttacatgattcccacagaagGgcaaccgcaatataagaagt	16	8	8	9	1	0	3	0	1	0	2	1	3	1	3	2	1	2	2	2	1	7	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:5080352G>A	uc010qyw.1	-	1	506	c.506C>T	c.(505-507)CCC>CTC	p.P169L		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCCACAGAAGGGCAACCGCAA	0.418													3	24					0	0	0	0	A	5080352	A	A	5080352	3	1	153	1	0	0	0	0	1	0	0	0	11169	1232	43	4	474	4	OR52E2	11	5080352	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	458003	5080352	129926164	134	27759											
OR56A1	120796	broad.mit.edu	37	chr11	6048851	6048851	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagagccagtgctgccaactCtggaagttggggaagcagat	11	7	15	8	0	1	2	0	0	1	2	1	5	1	4	2	3	5	3	2	3	3	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:6048851C>G	uc010qzw.1	-	1	84	c.84G>C	c.(82-84)CAG>CAC	p.Q28H		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	28	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGCCAACTCTGGAAGTTGG	0.577													7	111					0	0	0	0	G	6048851	G	G	6048851	3	3	153	1	0	0	0	0	1	0	0	0	11187	912	32	2	876	2	OR56A1	11	6048851	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	968499	6048851	128957665	135	27760											
ANO5	203859	broad.mit.edu	37	chr11	22301307	22301307	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagctggctaaatcaacacTctaatcagtatagtgaggaa	16	9	8	8	0	3	1	2	1	1	0	3	2	3	2	0	2	2	3	0	2	7	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:22301307T>C	uc001mqi.2	+	22	3055	c.2738T>C	c.(2737-2739)CTC>CCC	p.L913P	ANO5_uc001mqj.2_Missense_Mutation_p.L912P	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	913	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						AAATCAACACTCTAATCAGTA	0.408													5	22					0	0	0	0	C	22301307	C	C	22301307	3	2	153	1	0	0	0	0	1	0	0	0	700	1551	54	5	2824	5	ANO5	11	22301307	Missense_Mutation	SNP	T	TCGA-CR-7386-01A-11D-2012-08	16252456	22301307	112705209	136	27761											
TTC17	55761	broad.mit.edu	37	chr11	43436245	43436245	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattaaccaccaaatgtccaGagtgtgaaaacagcctgaag	17	7	8	9	0	0	3	0	2	0	1	1	3	1	3	4	0	3	0	4	0	6	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:43436245G>C	uc001mxi.2	+	16	2184	c.2170G>C	c.(2170-2172)GAG>CAG	p.E724Q	TTC17_uc001mxh.2_Missense_Mutation_p.E724Q|TTC17_uc010rfj.1_Missense_Mutation_p.E667Q|TTC17_uc001mxj.2_Missense_Mutation_p.E494Q	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	724							binding			ovary(5)	5						CAAATGTCCAGAGTGTGAAAA	0.438													9	91					0	0	0	0	C	43436245	C	C	43436245	3	2	153	1	0	0	0	0	1	0	0	0	16752	943	33	2	2232	2	TTC17	11	43436245	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	21134938	43436245	91570271	137	27762											
PYGM	5837	broad.mit.edu	37	chr11	64521767	64521767	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtccaccaggatcctcatCagctcggggatggccaggga	9	6	14	12	1	2	0	2	0	0	0	5	3	4	3	4	6	1	1	4	6	0	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:64521767C>G	uc001oax.3	-	9	1867	c.1050G>C	c.(1048-1050)CTG>CTC	p.L350L	PYGM_uc001oay.3_Silent_p.L262L	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	350					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	GGATCCTCATCAGCTCGGGGA	0.632													5	66					0	0	0	0	G	64521767	G	G	64521767	2	3	153	1	0	0	0	0	0	0	0	1	12927	813	29	2		2	PYGM	11	64521767	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	21085522	64521767	70484749	138	27763											
SF3B2	10992	broad.mit.edu	37	chr11	65829169	65829169	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccctcaggggaaggagttcGagacacgactgaaggagaag	13	5	15	8	2	1	3	1	1	0	2	3	8	2	5	1	4	0	1	1	4	3	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:65829169G>A	uc001ogy.1	+	15	1832	c.1792G>A	c.(1792-1794)GAG>AAG	p.E598K		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	598					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						GAAGGAGTTCGAGACACGACT	0.498													8	35					0	0	0	0	A	65829169	A	A	65829169	3	1	153	1	0	0	0	0	1	0	0	0	14216	1059	37	1	1850	1	SF3B2	11	65829169	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1307402	65829169	69177347	139	27764											
DPP3	10072	broad.mit.edu	37	chr11	66272236	66272236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcattgttcagcccaacactCgccttgaaggtaatgaggta	11	11	9	10	1	2	2	2	2	0	0	3	2	2	2	2	2	2	3	2	2	4	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:66272236C>T	uc001oig.1	+	17	2094	c.2032C>T	c.(2032-2034)CGC>TGC	p.R678C	DPP3_uc001oif.1_Missense_Mutation_p.R678C|DPP3_uc010rpe.1_Missense_Mutation_p.R667C|DPP3_uc001oih.1_Silent_p.L45L	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	678					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						GCCCAACACTCGCCTTGAAGG	0.567													19	101					0	0	0	0	T	66272236	T	T	66272236	3	4	153	1	0	0	0	0	1	0	0	0	4750	884	31	1	2094	1	DPP3	11	66272236	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	443067	66272236	68734280	140	27765											
CTSF	8722	broad.mit.edu	37	chr11	66335085	66335085	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactgggccacagtccttccGcagcagcacgtgtcttccga	7	8	10	16	3	1	0	0	0	1	0	4	1	4	0	4	1	2	3	4	1	0	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:66335085G>A	uc001oip.2	-	3	451	c.361C>T	c.(361-363)CGG>TGG	p.R121W		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	121					proteolysis	lysosome	cysteine-type endopeptidase activity				0						CAGTCCTTCCGCAGCAGCACG	0.592													12	135					0	0	0	0	A	66335085	A	A	66335085	3	1	153	1	0	0	0	0	1	0	0	0	4051	1086	38	1	1137	1	CTSF	11	66335085	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	62849	66335085	68671431	141	27766											
APOA5	116519	broad.mit.edu	37	chr11	116662530	116662530	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagggtcggagacccacctGaaagaagagccagagcccag	13	3	13	12	1	1	5	1	1	0	4	2	6	1	5	4	2	2	0	4	2	2	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:116662530G>A	uc001ppr.2	-	1	55	c.47C>T	c.(46-48)TCA>TTA	p.S16L	APOA5_uc009yze.2_Missense_Mutation_p.S16L|APOA5_uc009yzf.2_Missense_Mutation_p.S16L|APOA5_uc009yzg.2_Intron	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	16					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		AGACCCACCTGAAAGAAGAGC	0.632											OREG0021366|OREG0003485	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)|type=REGULATORY REGION|Gene=APOA5|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	4	30					0	0	0	0	A	116662530	A	A	116662530	3	1	153	1	0	0	0	0	1	0	0	0	784	1294	45	2	1065	2	APOA5	11	116662530	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	50327445	116662530	18343986	142	27767											
ABCG4	64137	broad.mit.edu	37	chr11	119025544	119025544	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacgaggacagccctgctctCtggcgggcagaggaagcgtc	8	5	15	13	3	1	1	0	0	1	1	3	4	1	3	1	4	3	2	1	4	1	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:119025544C>G	uc001pvs.2	+	6	941	c.605C>G	c.(604-606)TCT>TGT	p.S202C	ABCG4_uc009zar.2_Missense_Mutation_p.S202C	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	202	Cytoplasmic (Potential).|ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCCCTGCTCTCTGGCGGGCAG	0.622													17	142					0	0	0	0	G	119025544	G	G	119025544	3	3	153	1	0	0	0	0	1	0	0	0	70	913	32	2	623	2	ABCG4	11	119025544	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	2363014	119025544	15980972	143	27768											
OR8B4	283162	broad.mit.edu	37	chr11	124294739	124294739	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccacaaggataaactcaGtcactgaggagctgtttctc	12	10	8	11	0	3	1	2	1	1	0	5	3	4	3	1	2	2	2	1	2	3	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:124294739G>A	uc010sak.1	-	1	29	c.29C>T	c.(28-30)ACT>ATT	p.T10I		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GATAAACTCAGTCACTGAGGA	0.488													6	45					0	0	0	0	A	124294739	A	A	124294739	3	1	153	1	0	0	0	0	1	0	0	0	11283	1029	36	4	902	4	OR8B4	11	124294739	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	5269195	124294739	10711777	144	27769											
C12orf5	57103	broad.mit.edu	37	chr12	4459054	4459054	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taaagtatgactcaagacttCgggaaagggtgagtaactta	15	10	11	5	1	1	3	1	2	0	1	2	4	1	4	0	2	1	2	0	2	7	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:4459054C>T	uc001qmp.2	+	4	341	c.262C>T	c.(262-264)CGG>TGG	p.R88W		NM_020375	NP_065108	Q9NQ88	TIGAR_HUMAN	TP53-induced glycolysis and apoptosis regulator	88						intracellular	fructose-2,6-bisphosphate 2-phosphatase activity			skin(1)	1			all cancers(3;1.15e-07)|Colorectal(7;0.00165)|OV - Ovarian serous cystadenocarcinoma(31;0.00596)|COAD - Colon adenocarcinoma(12;0.0229)|GBM - Glioblastoma multiforme(3;0.0266)|STAD - Stomach adenocarcinoma(119;0.206)			CTCAAGACTTCGGGAAAGGGT	0.353													8	27					0	0	0	0	T	4459054	T	T	4459054	3	4	153	1	0	0	0	0	1	0	0	0	1700	875	31	1	276	1	C12orf5	12	4459054	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08		4459054	129392841	145	27770											
PCBP2	5094	broad.mit.edu	37	chr12	53849783	53849783	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatcattgacaaactggaaGaggtttgttgtctcccactc	10	13	9	9	0	2	3	1	2	1	1	4	4	2	4	1	2	1	2	1	2	2	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:53849783G>T	uc001sdl.3	+	5	591	c.241G>T	c.(241-243)GAG>TAG	p.E81*	PCBP2_uc001sdc.3_Nonsense_Mutation_p.E81*|PCBP2_uc001sdb.3_Nonsense_Mutation_p.E81*|PCBP2_uc001sde.3_Nonsense_Mutation_p.E81*|PCBP2_uc001sdi.3_Nonsense_Mutation_p.E81*|PCBP2_uc001sdd.3_Nonsense_Mutation_p.E81*|PCBP2_uc001sdf.3_Nonsense_Mutation_p.E81*|PCBP2_uc009zna.2_Intron|PCBP2_uc010soh.1_Nonsense_Mutation_p.E81*|PCBP2_uc009zmz.1_Intron	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	81					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						CAAACTGGAAGAGGTTTGTTG	0.413													15	189					2.35188e-11	2.57237e-11	1	0	T	53849783	T	T	53849783	4	4	153	1	0	0	0	0	0	1	0	0	11555	943	33	2	255	2	PCBP2	12	53849783	Nonsense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	49390729	53849783	80002112	146	27771											
GRIP1	23426	broad.mit.edu	37	chr12	66786483	66786483	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctgtttcttaattttcaagGtgacagtctctcctgccatc	7	17	6	11	0	4	1	1	1	3	0	7	1	5	1	2	1	1	1	2	1	2	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:66786483G>T	uc001stk.2	-	17	2328	c.2087C>A	c.(2086-2088)ACC>AAC	p.T696N	GRIP1_uc010sta.1_Missense_Mutation_p.T640N|GRIP1_uc001stj.2_Missense_Mutation_p.T478N|GRIP1_uc001stl.1_Missense_Mutation_p.T588N|GRIP1_uc001stm.2_Missense_Mutation_p.T696N	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	748	PDZ 6.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		AATTTTCAAGGTGACAGTCTC	0.428													10	94					0.000442599	0.000474819	1	0	T	66786483	T	T	66786483	3	4	153	1	0	0	0	0	1	0	0	0	6826	1261	44	4	1175	4	GRIP1	12	66786483	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	12936700	66786483	67065412	147	27772											
PTPRB	5787	broad.mit.edu	37	chr12	70931979	70931979	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcagagcaaggatcatcatCtacattggagagcttcactc	12	10	9	10	0	5	2	4	0	1	2	6	4	5	3	0	2	3	2	0	2	2	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:70931979C>G	uc001swb.3	-	26	5278	c.5248G>C	c.(5248-5250)GAT>CAT	p.D1750H	uc001svz.2_RNA|PTPRB_uc010sto.1_Missense_Mutation_p.D1660H|PTPRB_uc010stp.1_Missense_Mutation_p.D1660H|PTPRB_uc001swc.3_Missense_Mutation_p.D1968H|PTPRB_uc001swa.3_Missense_Mutation_p.D1880H	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1750	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGATCATCATCTACATTGGAG	0.428													10	58					0	0	0	0	G	70931979	G	G	70931979	3	3	153	1	0	0	0	0	1	0	0	0	12861	913	32	2	773	2	PTPRB	12	70931979	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	4145496	70931979	62919916	148	27773											
PMCH	5367	broad.mit.edu	37	chr12	102591364	102591364	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catttttatattgttccaggGaaggagcaataactgatttt	12	16	8	5	0	0	1	0	1	0	0	1	3	1	3	1	2	2	2	1	2	5	9			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:102591364G>T	uc001tjl.2	-	1	251	c.185C>A	c.(184-186)TCC>TAC	p.S62Y		NM_002674	NP_002665	P20382	MCH_HUMAN	pro-melanin-concentrating hormone	62					cell differentiation|neuropeptide signaling pathway|spermatogenesis|synaptic transmission		melanin-concentrating hormone activity				0						TTGTTCCAGGGAAGGAGCAAT	0.353													10	39					0.00621372	0.00651626	1	0	T	102591364	T	T	102591364	3	4	153	1	0	0	0	0	1	0	0	0	12186	1174	41	2	324	2	PMCH	12	102591364	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	31659385	102591364	31260531	149	27774											
APPL2	55198	broad.mit.edu	37	chr12	105568151	105568151	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatcatcgtcatctggttGatcgtttaacagtacatatt	10	16	6	9	2	3	1	2	1	1	0	6	1	4	1	1	1	2	3	1	1	3	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:105568151G>A	uc001tlf.1	-	21	2154	c.1936C>T	c.(1936-1938)CAA>TAA	p.Q646*	APPL2_uc010swt.1_Nonsense_Mutation_p.Q603*|APPL2_uc001tlg.1_Nonsense_Mutation_p.Q400*|APPL2_uc010swu.1_Nonsense_Mutation_p.Q652*	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	646					cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						TCATCTGGTTGATCGTTTAAC	0.453													7	43					0	0	0	0	A	105568151	A	A	105568151	4	1	153	1	0	0	0	0	0	1	0	0	818	1299	45	2	62	2	APPL2	12	105568151	Nonsense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	2976787	105568151	28283744	150	27775											
RIC8B	55188	broad.mit.edu	37	chr12	107245264	107245264	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggatgtgacaaatcgacctGaagttggctcaactgtgaga	12	9	13	7	1	1	3	1	3	0	1	2	6	1	4	1	2	1	2	1	2	3	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:107245264G>A	uc001tlx.2	+	7	1323	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	RIC8B_uc001tlw.2_Missense_Mutation_p.E400K|RIC8B_uc001tly.2_Missense_Mutation_p.E360K|RIC8B_uc001tlz.2_RNA|RIC8B_uc009zur.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	400					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						AAATCGACCTGAAGTTGGCTC	0.448													8	76					0	0	0	0	A	107245264	A	A	107245264	3	1	153	1	0	0	0	0	1	0	0	0	13421	1291	45	2	1224	2	RIC8B	12	107245264	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1677113	107245264	26606631	151	27776											
RIC8B	55188	broad.mit.edu	37	chr12	107245315	107245315	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcgcctcatgacacatgttGaccttggagtcaagcaaatt	11	11	9	10	1	2	2	2	2	0	0	2	3	2	3	2	1	2	2	2	1	2	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:107245315G>A	uc001tlx.2	+	7	1374	c.1249G>A	c.(1249-1251)GAC>AAC	p.D417N	RIC8B_uc001tlw.2_Missense_Mutation_p.D417N|RIC8B_uc001tly.2_Missense_Mutation_p.D377N|RIC8B_uc001tlz.2_RNA|RIC8B_uc009zur.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	417					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						GACACATGTTGACCTTGGAGT	0.448													6	68					0	0	0	0	A	107245315	A	A	107245315	3	1	153	1	0	0	0	0	1	0	0	0	13421	1290	45	2	1275	2	RIC8B	12	107245315	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	51	107245315	26606580	152	27777											
ATXN2	6311	broad.mit.edu	37	chr12	111956093	111956093	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgaaccagaattcgggttGaaatctgaagtgtgagaagt	13	11	12	5	1	2	5	0	4	2	2	3	6	2	5	1	1	1	1	1	1	5	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:111956093G>A	uc001tsj.2	-	9	1767	c.1605C>T	c.(1603-1605)TTC>TTT	p.F535F	ATXN2_uc001tsh.2_Silent_p.F270F|ATXN2_uc001tsi.2_Silent_p.F246F|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_Silent_p.F270F	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	535					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						AATTCGGGTTGAAATCTGAAG	0.423													15	73					0	0	0	0	A	111956093	A	A	111956093	2	1	153	1	0	0	0	0	0	0	0	1	1213	1281	45	2		2	ATXN2	12	111956093	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	4710778	111956093	21895802	153	27778											
MED13L	23389	broad.mit.edu	37	chr12	116429339	116429339	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcccgacatccgcccctttGatgttcatgttgcaggcaca	8	10	9	14	2	1	1	1	1	0	0	2	2	2	1	4	1	2	4	4	1	0	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:116429339G>C	uc001tvw.2	-	17	3475	c.3420C>G	c.(3418-3420)ATC>ATG	p.I1140M		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1140					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CCGCCCCTTTGATGTTCATGT	0.473													16	70					0	0	0	0	C	116429339	C	C	116429339	3	2	153	1	0	0	0	0	1	0	0	0	9484	1280	45	2	3272	2	MED13L	12	116429339	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	4473246	116429339	17422556	154	27779											
AKAP11	11215	broad.mit.edu	37	chr13	42873613	42873613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagctctggacagcagaagtCattggctaaaccctcaactt	12	10	8	11	0	3	1	2	0	1	1	3	2	3	2	1	2	4	3	1	2	5	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr13:42873613C>T	uc001uys.1	+	8	906	c.731C>T	c.(730-732)TCA>TTA	p.S244L		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	244	Ser-rich.				intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CAGCAGAAGTCATTGGCTAAA	0.443													15	56					0	0	0	0	T	42873613	T	T	42873613	3	4	153	1	0	0	0	0	1	0	0	0	447	838	29	2	753	2	AKAP11	13	42873613	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08		42873613	72296265	155	27780											
PCDH17	27253	broad.mit.edu	37	chr13	58208221	58208221	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcctactctatcctgccctCgcacatcggcgacgtgtcta	7	11	7	16	4	2	0	0	0	2	0	6	1	4	0	3	1	2	1	3	1	3	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr13:58208221C>T	uc001vhq.1	+	1	2433	c.1541C>T	c.(1540-1542)TCG>TTG	p.S514L	PCDH17_uc010aec.1_Missense_Mutation_p.S514L	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	514	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATCCTGCCCTCGCACATCGGC	0.592													8	39					0	0	0	0	T	58208221	T	T	58208221	3	4	153	1	0	0	0	0	1	0	0	0	11566	893	31	1	1543	1	PCDH17	13	58208221	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	15334608	58208221	56961657	156	27781											
RNF219	79596	broad.mit.edu	37	chr13	79209281	79209281	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatcaacttcagccttcagtCgtaaattctccctcaccaga	11	12	4	14	1	5	1	4	0	1	1	7	1	5	1	3	0	2	1	3	0	4	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr13:79209281C>T	uc001vkw.1	-	5	661	c.602G>A	c.(601-603)CGA>CAA	p.R201Q	RNF219_uc010afb.1_5'UTR|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	201	Potential.						zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		AGCCTTCAGTCGTAAATTCTC	0.343													7	50					0	0	0	0	T	79209281	T	T	79209281	3	4	153	1	0	0	0	0	1	0	0	0	13547	884	31	1	1586	1	RNF219	13	79209281	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	21001060	79209281	35960597	157	27782											
GPC6	10082	broad.mit.edu	37	chr13	94938726	94938726	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaacagcatgcaggtgtCtgcaaaggtatttgcattag	14	10	11	6	0	1	1	0	0	1	1	1	1	1	1	0	2	5	5	0	2	5	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr13:94938726C>A	uc001vlt.2	+	5	1633	c.1001C>A	c.(1000-1002)TCT>TAT	p.S334Y	GPC6_uc010tig.1_Missense_Mutation_p.S334Y	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	334						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				ATGCAGGTGTCTGCAAAGGTA	0.418													5	41					0.00116845	0.00123458	1	0	A	94938726	A	A	94938726	3	1	153	1	0	0	0	0	1	0	0	0	6640	913	32	2	1019	2	GPC6	13	94938726	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	15729445	94938726	20231152	158	27783											
CDH24	64403	broad.mit.edu	37	chr14	23523465	23523465	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcgttgtcccccaggtctGggtcctgggcccggagccgg	2	7	18	14	3	1	0	0	0	1	0	3	1	3	1	5	6	1	1	5	6	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:23523465G>A	uc001wil.2	-	6	1117	c.857C>T	c.(856-858)CCA>CTA	p.P286L	CDH24_uc010akf.2_Missense_Mutation_p.P286L|CDH24_uc001win.3_Missense_Mutation_p.P286L	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	286	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CCCCAGGTCTGGGTCCTGGGC	0.637													35	164					0	0	0	0	A	23523465	A	A	23523465	3	1	153	1	0	0	0	0	1	0	0	0	3124	1348	47	4	1634	4	CDH24	14	23523465	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		23523465	83826075	159	27784											
MYH7	4625	broad.mit.edu	37	chr14	23897712	23897712	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaggccaaagaggcaccttCtcgatgaggtcaatgcaggc	12	7	12	10	1	2	2	1	1	1	1	3	3	2	2	2	4	1	2	2	4	3	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:23897712C>T	uc001wjx.2	-	15	1681	c.1575G>A	c.(1573-1575)GAG>GAA	p.E525E		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	525	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GAGGCACCTTCTCGATGAGGT	0.502													7	50					0	0	0	0	T	23897712	T	T	23897712	2	4	153	1	0	0	0	0	0	0	0	1	10092	912	32	2		2	MYH7	14	23897712	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	374247	23897712	83451828	160	27785											
FAM179B	23116	broad.mit.edu	37	chr14	45432505	45432505	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggccaagacaggtttcaatCttacatttctcgtctgccct	8	14	7	12	1	4	1	1	0	3	1	5	1	4	1	2	2	2	1	2	2	3	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:45432505C>G	uc001wvv.2	+	1	1090	c.881C>G	c.(880-882)TCT>TGT	p.S294C	FAM179B_uc001wvw.2_Missense_Mutation_p.S294C|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.S294C|FAM179B_uc001wvu.2_Missense_Mutation_p.S294C	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	294							binding			skin(2)|upper_aerodigestive_tract(1)	3						AGGTTTCAATCTTACATTTCT	0.498													20	89					0	0	0	0	G	45432505	G	G	45432505	3	3	153	1	0	0	0	0	1	0	0	0	5534	913	32	2	883	2	FAM179B	14	45432505	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	21534793	45432505	61917035	161	27786											
PPM1A	5494	broad.mit.edu	37	chr14	60750214	60750214	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaagtcactgatgaccttGagaaagtttgcaatgaagta	14	12	10	5	0	1	5	1	5	0	1	1	6	1	5	1	0	1	3	1	0	5	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:60750214G>C	uc010apn.2	+	3	1195	c.793G>C	c.(793-795)GAG>CAG	p.E265Q	PPM1A_uc001xew.3_Missense_Mutation_p.E338Q|PPM1A_uc001xex.3_Missense_Mutation_p.E265Q|PPM1A_uc001xey.3_Missense_Mutation_p.E265Q	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	265					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		TGATGACCTTGAGAAAGTTTG	0.348													8	86					0	0	0	0	C	60750214	C	C	60750214	3	2	153	1	0	0	0	0	1	0	0	0	12395	1291	45	2	1018	2	PPM1A	14	60750214	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	15317709	60750214	46599326	162	27787											
ESRRB	2103	broad.mit.edu	37	chr14	76966231	76966231	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaagagcagcttagaggatCtcccaaggatgaaagaatgt	15	7	11	8	0	1	4	0	1	1	3	2	6	1	6	2	2	2	2	2	2	5	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:76966231C>G	uc001xsr.2	+	10	1693	c.1322C>G	c.(1321-1323)TCT>TGT	p.S441C	ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	441						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CTTAGAGGATCTCCCAAGGAT	0.512													6	53					0	0	0	0	G	76966231	G	G	76966231	3	3	153	1	0	0	0	0	1	0	0	0	5285	913	32	2	1348	2	ESRRB	14	76966231	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	16216017	76966231	30383309	163	27788											
ASB2	51676	broad.mit.edu	37	chr14	94417555	94417555	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctgcattgtgctgcaccaGaatcttcacggcctccgcgt	6	11	10	14	3	3	1	1	0	2	1	4	1	4	1	3	1	3	3	3	1	1	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:94417555G>C	uc001ycc.1	-	4	1015	c.526C>G	c.(526-528)CTG>GTG	p.L176V	ASB2_uc001ycd.2_Missense_Mutation_p.L224V|ASB2_uc001yce.1_Missense_Mutation_p.L122V	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	176	ANK 4.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		TGCTGCACCAGAATCTTCACG	0.617													5	57					0	0	0	0	C	94417555	C	C	94417555	3	2	153	1	0	0	0	0	1	0	0	0	1025	933	33	2	1257	2	ASB2	14	94417555	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	17451324	94417555	12931985	164	27789											
DYNC1H1	1778	broad.mit.edu	37	chr14	102476268	102476268	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcaccatgaaccctggctaCgcgggccggtctaaccttcc	8	8	9	16	3	2	1	1	1	1	0	3	1	3	1	5	3	3	1	5	3	3	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:102476268C>T	uc001yks.2	+	30	6230	c.6066C>T	c.(6064-6066)TAC>TAT	p.Y2022Y		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2022	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						ACCCTGGCTACGCGGGCCGGT	0.552													7	38					0	0	0	0	T	102476268	T	T	102476268	2	4	153	1	0	0	0	0	0	0	0	1	4863	547	19	1		1	DYNC1H1	14	102476268	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	8058713	102476268	4873272	165	27790											
HSP90AA1	3320	broad.mit.edu	37	chr14	102552205	102552205	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcagcaaccaaataagcaGaataaaaaccaacaccgaac	21	4	4	12	1	1	1	1	0	1	1	2	2	1	1	3	0	6	2	3	0	9	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:102552205G>A	uc001yku.3	-	3	609	c.419C>T	c.(418-420)TCT>TTT	p.S140F	HSP90AA1_uc001ykv.3_Missense_Mutation_p.S262F|HSP90AA1_uc001ykw.1_Intron|HSP90AA1_uc001ykx.1_Missense_Mutation_p.S129F	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	140					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CAAATAAGCAGAATAAAAACC	0.473													16	52					0	0	0	0	A	102552205	A	A	102552205	3	1	153	1	0	0	0	0	1	0	0	0	7440	942	33	2	1815	2	HSP90AA1	14	102552205	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	75937	102552205	4797335	166	27791											
NIPA2	81614	broad.mit.edu	37	chr15	23012399	23012399	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacccaattttcccatgaaGattaagtctttcattgagaa	14	13	5	9	0	2	3	1	2	1	2	3	4	3	3	2	0	0	0	2	0	4	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr15:23012399G>A	uc001yux.2	-	7	941	c.328C>T	c.(328-330)CTT>TTT	p.L110F	NIPA2_uc001yuy.2_Missense_Mutation_p.L110F|NIPA2_uc001yuz.2_Missense_Mutation_p.L110F|NIPA2_uc001yva.2_Missense_Mutation_p.L91F|NIPA2_uc001yvb.2_Missense_Mutation_p.L110F|NIPA2_uc010ayb.2_Missense_Mutation_p.L91F	NM_030922	NP_112184	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome	110	Helical; (Potential).					early endosome|integral to membrane|plasma membrane				haematopoietic_and_lymphoid_tissue(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		TTCCCATGAAGATTAAGTCTT	0.333													9	67					0	0	0	0	A	23012399	A	A	23012399	3	1	153	1	0	0	0	0	1	0	0	0	10477	942	33	2	762	2	NIPA2	15	23012399	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		23012399	79518993	167	27792											
RYR3	6263	broad.mit.edu	37	chr15	34131070	34131070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagcttaaagcatgggcctGaagtgggtttgggtgacctc	8	10	15	8	0	0	2	0	2	0	0	1	2	0	2	2	3	2	4	2	3	3	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr15:34131070G>A	uc001zhi.2	+	89	12959	c.12889G>A	c.(12889-12891)GAA>AAA	p.E4297K	RYR3_uc010bar.2_Missense_Mutation_p.E4292K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4297					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCATGGGCCTGAAGTGGGTTT	0.458													7	34					0	0	0	0	A	34131070	A	A	34131070	3	1	153	1	0	0	0	0	1	0	0	0	13835	1291	45	2	13243	2	RYR3	15	34131070	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	11118671	34131070	68400322	168	27793											
SEMA6D	80031	broad.mit.edu	37	chr15	48056145	48056145	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatttctaaaggctcggctGaactgttctgtccctggaga	8	13	10	10	1	3	2	1	1	2	1	5	3	4	2	1	3	1	3	1	3	3	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr15:48056145G>C	uc010bek.2	+	10	1206	c.846G>C	c.(844-846)CTG>CTC	p.L282L	SEMA6D_uc001zvw.2_Silent_p.L282L|SEMA6D_uc001zvx.1_Silent_p.L282L|SEMA6D_uc001zvy.2_Silent_p.L282L|SEMA6D_uc001zvz.2_Silent_p.L282L|SEMA6D_uc001zwa.2_Silent_p.L282L|SEMA6D_uc001zwb.2_Silent_p.L282L|SEMA6D_uc001zwc.2_Silent_p.L282L	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	282	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		AGGCTCGGCTGAACTGTTCTG	0.488													11	86					0	0	0	0	C	48056145	C	C	48056145	2	2	153	1	0	0	0	0	0	0	0	1	14107	1277	45	2		2	SEMA6D	15	48056145	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	13925075	48056145	54475247	169	27794											
C15orf42	90381	broad.mit.edu	37	chr15	90167507	90167507	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatgtgatgtctccaagaaGagtccatttaggaaatctaa	14	13	8	6	0	2	3	0	1	2	2	4	4	3	4	2	1	0	0	2	1	6	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr15:90167507G>C	uc002boe.2	+	20	3966	c.3966G>C	c.(3964-3966)AAG>AAC	p.K1322N	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1322	Pro-rich.				cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TCTCCAAGAAGAGTCCATTTA	0.463													10	128					0	0	0	0	C	90167507	C	C	90167507	3	2	153	1	0	0	0	0	1	0	0	0	1802	933	33	2	4044	2	C15orf42	15	90167507	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	42111362	90167507	12363885	170	27795											
HS3ST6	64711	broad.mit.edu	37	chr16	1962054	1962054	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agagcgtctgggcgtagtcgGagatggcccgggtcacgggg	6	6	20	9	5	2	2	1	0	1	2	3	3	2	2	1	6	1	1	1	6	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:1962054G>A	uc002cnf.2	-	2	473	c.473C>T	c.(472-474)TCC>TTC	p.S158F		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	158											0						GGCGTAGTCGGAGATGGCCCG	0.716													5	31					0	0	0	0	A	1962054	A	A	1962054	3	1	153	1	0	0	0	0	1	0	0	0	7408	1174	41	2	466	2	HS3ST6	16	1962054	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		1962054	88392699	171	27796											
KIAA0556	23247	broad.mit.edu	37	chr16	27751533	27751533	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatgaacgctcactcggaaGaaagcaaaggcacccatgag	15	4	10	12	2	1	3	1	2	0	1	2	4	1	4	2	2	2	3	2	2	4	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:27751533G>C	uc002dow.2	+	15	1939	c.1915G>C	c.(1915-1917)GAA>CAA	p.E639Q		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	639	Potential.									ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TCACTCGGAAGAAAGCAAAGG	0.562													7	59					0	0	0	0	C	27751533	C	C	27751533	3	2	153	1	0	0	0	0	1	0	0	0	8222	943	33	2	1973	2	KIAA0556	16	27751533	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	25789479	27751533	62603220	172	27797											
SRCAP	10847	broad.mit.edu	37	chr16	30749246	30749246	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaggcaccagattctgctGaggggaccacccttacagtg	10	7	13	11	0	1	2	0	1	1	1	1	4	1	4	3	4	2	2	3	4	1	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:30749246G>A	uc002dze.1	+	34	8270	c.7885G>A	c.(7885-7887)GAG>AAG	p.E2629K	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.E2424K	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2629	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			AGATTCTGCTGAGGGGACCAC	0.582													16	80					0	0	0	0	A	30749246	A	A	30749246	3	1	153	1	0	0	0	0	1	0	0	0	15201	1291	45	2	8011	2	SRCAP	16	30749246	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	2997713	30749246	59605507	173	27798											
ZNF423	23090	broad.mit.edu	37	chr16	49672763	49672763	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagacgaggccacccaggaGagttgtgggtcgtcatcacc	9	6	15	11	2	2	2	2	0	0	2	3	5	2	2	3	4	0	1	3	4	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:49672763G>A	uc002efs.2	-	5	598	c.300C>T	c.(298-300)CTC>CTT	p.L100L	ZNF423_uc010vgn.1_5'UTR	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	100					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CCACCCAGGAGAGTTGTGGGT	0.587													6	45					0	0	0	0	A	49672763	A	A	49672763	2	1	153	1	0	0	0	0	0	0	0	1	17965	929	33	2		2	ZNF423	16	49672763	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	18923517	49672763	40681990	174	27799											
TK2	7084	broad.mit.edu	37	chr16	66562953	66562953	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgaatcgacctctccatCaaccgtacagatgacaccta	12	9	6	14	2	2	3	1	2	1	1	4	4	2	3	4	0	2	1	4	0	4	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:66562953C>T	uc002eos.2	-	6	744	c.519G>A	c.(517-519)TTG>TTA	p.L173L	TK2_uc010vip.1_Silent_p.L34L|TK2_uc002eor.2_Silent_p.L100L|TK2_uc010cdq.2_Silent_p.L100L|TK2_uc010cdr.2_Silent_p.L82L|TK2_uc010viq.1_Silent_p.L155L|TK2_uc010vir.1_Silent_p.L148L	NM_004614	NP_004605	O00142	KITM_HUMAN	thymidine kinase 2, mitochondrial	131					pyrimidine base metabolic process|pyrimidine nucleoside salvage	mitochondrial matrix	ATP binding|phosphotransferase activity, alcohol group as acceptor|thymidine kinase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0736)|Epithelial(162;0.237)		ACCTCTCCATCAACCGTACAG	0.393													16	76					0	0	0	0	T	66562953	T	T	66562953	2	4	153	1	0	0	0	0	0	0	0	1	15999	825	29	2		2	TK2	16	66562953	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	16890190	66562953	23791800	175	27800											
ZFHX3	463	broad.mit.edu	37	chr16	72984803	72984803	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagctctcgcccaggttcatCagctcctctgacaccagctg	8	9	8	16	1	4	1	2	1	2	0	6	1	5	1	3	1	3	4	3	1	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:72984803C>T	uc002fck.2	-	3	3454	c.2781G>A	c.(2779-2781)CTG>CTA	p.L927L	ZFHX3_uc002fcl.2_Silent_p.L13L	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	927					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CCAGGTTCATCAGCTCCTCTG	0.617													10	58					0	0	0	0	T	72984803	T	T	72984803	2	4	153	1	0	0	0	0	0	0	0	1	17701	813	29	2		2	ZFHX3	16	72984803	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	6421850	72984803	17369950	176	27801											
ALOX15	246	broad.mit.edu	37	chr17	4535217	4535217	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtctgcccagctgccaagtGatggacatctggagagaagc	10	7	13	11	1	2	2	0	1	2	1	2	5	2	4	2	2	4	1	2	2	2	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:4535217G>A	uc002fyh.2	-	13	1790	c.1776C>T	c.(1774-1776)ATC>ATT	p.I592I	ALOX15_uc010vsd.1_Silent_p.I553I|ALOX15_uc010vse.1_Silent_p.I614I	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	592	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	GCTGCCAAGTGATGGACATCT	0.627													4	47					0	0	0	0	A	4535217	A	A	4535217	2	1	153	1	0	0	0	0	0	0	0	1	538	1280	45	2		2	ALOX15	17	4535217	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08		4535217	76659993	177	27802											
TP53	7157	broad.mit.edu	37	chr17	7578217	7578218	+	Frame_Shift_Del	DEL	GT	-	-																															ccaccacactatgtcgaaaaGtgtttctgtcatccaaatac																										TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:7578217_7578218delGT	uc002gim.2	-	6	825_826	c.631_632delAC	c.(631-633)ACTfs	p.T211fs	TP53_uc002gig.1_Frame_Shift_Del_p.T211fs|TP53_uc002gih.2_Frame_Shift_Del_p.T211fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.T79fs|TP53_uc010cng.1_Frame_Shift_Del_p.T79fs|TP53_uc002gii.1_Frame_Shift_Del_p.T79fs|TP53_uc010cnh.1_Frame_Shift_Del_p.T211fs|TP53_uc010cni.1_Frame_Shift_Del_p.T211fs|TP53_uc002gij.2_Frame_Shift_Del_p.T211fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.T118fs|TP53_uc002gio.2_Frame_Shift_Del_p.T79fs|TP53_uc010vug.1_Frame_Shift_Del_p.T172fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	211	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in sporadic cancers; somatic mutation).|T -> I (in sporadic cancers; somatic mutation).|T -> N (in sporadic cancers; somatic mutation).|T -> S (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T211T(9)|p.T211I(7)|p.0?(7)|p.T211N(4)|p.T211fs*4(3)|p.R209fs*35(2)|p.T211fs*36(2)|p.T211fs*5(2)|p.T211A(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.T211_F212insX(1)|p.R209fs*36(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.D208fs*1(1)|p.R209_R213delRNTFR(1)|p.T211fs*28(1)|p.D207_V216del10(1)|p.T211P(1)|p.T211S(1)|p.R209fs*6(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGTCGAAAAGTGTTTCTGTCA	0.535		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578218	-	-	7578217	7	5	153	1	0	1	0	1	0	0	0	0	16448	1029	36	0	662	0	TP53	17	7578217	Frame_Shift_Del	DEL	GT	TCGA-CR-7386-01A-11D-2012-08	3043000	7578217	73616993	178	27803											
CCDC144A	9720	broad.mit.edu	37	chr17	16594003	16594003	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgggcgacgtccctggggtgGagcacatcttagctcctgga	6	8	15	12	3	1	0	0	0	1	0	3	3	3	2	2	5	2	2	2	5	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:16594003G>C	uc002gqk.1	+	1	365	c.289G>C	c.(289-291)GAG>CAG	p.E97Q		NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	97											0						CCCTGGGGTGGAGCACATCTT	0.647													69	197					0	0	0	0	C	16594003	C	C	16594003	3	2	153	1	0	0	0	0	1	0	0	0	2789	1175	41	2	291	2	CCDC144A	17	16594003	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	9015786	16594003	64601207	179	27804											
KRT13	3860	broad.mit.edu	37	chr17	39659616	39659616	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccaggtcagtcttagacaGagtgagctcatccagcaccc	10	8	9	14	0	3	3	2	1	1	2	5	3	5	3	3	1	2	2	3	1	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:39659616G>A	uc002hwu.1	-	3	721	c.658C>T	c.(658-660)CTG>TTG	p.L220L	KRT13_uc002hwv.1_Silent_p.L220L|KRT13_uc002hww.2_Silent_p.L113L|KRT13_uc010wfr.1_Silent_p.L113L|KRT13_uc010cxo.2_Silent_p.L220L|KRT13_uc002hwx.1_Silent_p.L208L	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	220	Coil 1B.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GTCTTAGACAGAGTGAGCTCA	0.527													20	111					0	0	0	0	A	39659616	A	A	39659616	2	1	153	1	0	0	0	0	0	0	0	1	8489	933	33	2		2	KRT13	17	39659616	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	23065613	39659616	41535594	180	27805											
WNT3	7473	broad.mit.edu	37	chr17	44895960	44895960	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagcccgagcaggtggggctCcattagaagaggcgccgagg	9	4	17	11	3	0	2	0	0	0	2	1	4	1	2	3	5	2	2	3	5	2	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:44895960C>G	uc002ikv.2	-	1	123	c.4G>C	c.(4-6)GAG>CAG	p.E2Q		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	2					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			AGGTGGGGCTCCATTAGAAGA	0.602													2	9					0	0	0	0	G	44895960	G	G	44895960	3	3	153	1	0	0	0	0	1	0	0	0	17456	864	30	2	1079	2	WNT3	17	44895960	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	5236344	44895960	36299250	181	27806											
CSHL1	1444	broad.mit.edu	37	chr17	61988231	61988231	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggacggcaccagcctcttGaagccagggcaggcagagca	10	5	14	12	1	1	2	0	1	1	1	1	3	1	3	3	4	3	4	3	4	1	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:61988231G>C	uc002jda.1	-	2	126	c.64C>G	c.(64-66)CAA>GAA	p.Q22E	CSHL1_uc002jcz.1_Missense_Mutation_p.Q22E|CSHL1_uc002jdb.1_Intron|CSHL1_uc002jdc.1_Intron|CSHL1_uc002jdd.1_Missense_Mutation_p.Q22E|CSHL1_uc002jde.2_Missense_Mutation_p.Q50E|CSHL1_uc002jdf.2_Intron|CSHL1_uc002jdg.2_Missense_Mutation_p.Q22E|CSHL1_uc002jdh.2_Intron	NM_022579	NP_072101	Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	22						extracellular region	hormone activity|metal ion binding				0						CCAGCCTCTTGAAGCCAGGGC	0.612													5	57					0	0	0	0	C	61988231	C	C	61988231	3	2	153	1	0	0	0	0	1	0	0	0	3959	1299	45	2	620	2	CSHL1	17	61988231	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	17092271	61988231	19206979	182	27807											
COG1	9382	broad.mit.edu	37	chr17	71189326	71189326	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tggagcgccaggttcgggccGagatcgagcacaagaaggag	11	4	17	9	4	0	2	0	0	0	2	2	6	0	4	2	4	2	2	2	4	2	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:71189326G>C	uc002jjg.2	+	1	154	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	COG1_uc002jjh.2_Missense_Mutation_p.E40Q|COG1_uc002jjf.1_Missense_Mutation_p.E40Q	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	40					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			GGTTCGGGCCGAGATCGAGCA	0.687													5	17					0	0	0	0	C	71189326	C	C	71189326	3	2	153	1	0	0	0	0	1	0	0	0	3672	1059	37	3	120	3	COG1	17	71189326	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	9201095	71189326	10005884	183	27808											
C17orf77	146723	broad.mit.edu	37	chr17	72588192	72588192	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatatgggcatggatggatGaattggcgctgtcattttcc	9	13	13	6	1	1	1	1	1	0	0	2	4	2	3	1	4	0	2	1	4	3	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:72588192G>A	uc002jla.1	+	3	369	c.7G>A	c.(7-9)GAA>AAA	p.E3K	CD300LD_uc002jkz.2_Intron	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	3						extracellular region					0						ATGGATGGATGAATTGGCGCT	0.443													19	139					0	0	0	0	A	72588192	A	A	72588192	3	1	153	1	0	0	0	0	1	0	0	0	1890	1291	45	2	9	2	C17orf77	17	72588192	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1398866	72588192	8607018	184	27809											
HGS	9146	broad.mit.edu	37	chr17	79663007	79663007	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgcagctgctggagctgctCaaccagctggacgagcgcag	8	5	14	14	3	1	0	1	0	0	0	1	3	1	2	2	2	7	7	2	2	1	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:79663007C>T	uc002kbg.2	+	15	1448	c.1371C>T	c.(1369-1371)CTC>CTT	p.L457L		NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	457	Interaction with STAM1 (By similarity).|Interaction with SNAP25 and TRAK2 (By similarity).|Interaction with SNX1 (By similarity).				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			TGGAGCTGCTCAACCAGCTGG	0.672													4	49					0	0	0	0	T	79663007	T	T	79663007	2	4	153	1	0	0	0	0	0	0	0	1	7126	813	29	2		2	HGS	17	79663007	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	7074815	79663007	1532203	185	27810											
ASXL3	80816	broad.mit.edu	37	chr18	31318686	31318686	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taatggcagaattggagtcaGaggatatcttgatccctgaa	13	11	11	6	0	2	4	1	2	1	2	3	6	3	6	1	3	0	1	1	3	4	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr18:31318686G>A	uc010dmg.1	+	11	1373	c.1318G>A	c.(1318-1320)GAG>AAG	p.E440K	ASXL3_uc002kxq.2_Missense_Mutation_p.E147K	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ATTGGAGTCAGAGGATATCTT	0.413													13	49					0	0	0	0	A	31318686	A	A	31318686	3	1	153	1	0	0	0	0	1	0	0	0	1070	943	33	2	1360	2	ASXL3	18	31318686	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		31318686	46758562	186	27811											
TCF4	6925	broad.mit.edu	37	chr18	52928732	52928732	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccagagcatctccagtctGggagctgccggctgccccgc	5	6	12	18	2	2	1	0	0	2	1	3	2	2	2	6	2	4	3	6	2	0	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr18:52928732G>T	uc002lfz.2	-	12	1567	c.955C>A	c.(955-957)CAG>AAG	p.Q319K	TCF4_uc002lfw.3_Missense_Mutation_p.Q159K|TCF4_uc010xdu.1_Missense_Mutation_p.Q189K|TCF4_uc010xdv.1_Missense_Mutation_p.Q189K|TCF4_uc002lfx.2_Missense_Mutation_p.Q248K|TCF4_uc010xdw.1_Missense_Mutation_p.Q189K|TCF4_uc002lfy.2_Missense_Mutation_p.Q277K|TCF4_uc010xdx.1_Missense_Mutation_p.Q295K|TCF4_uc010dph.1_Missense_Mutation_p.Q319K|TCF4_uc010xdy.1_Missense_Mutation_p.Q295K|TCF4_uc002lga.2_Missense_Mutation_p.Q421K|TCF4_uc002lgb.1_Missense_Mutation_p.Q159K|TCF4_uc010dpi.2_Missense_Mutation_p.Q325K|TCF4_uc002lfv.2_Missense_Mutation_p.Q103K	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	319					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		TCTCCAGTCTGGGAGCTGCCG	0.458													43	227					8.17448e-37	9.04685e-37	1	0	T	52928732	T	T	52928732	3	4	153	1	0	0	0	0	1	0	0	0	15761	1357	47	4	1092	4	TCF4	18	52928732	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	21610046	52928732	25148516	187	27812											
MALT1	10892	broad.mit.edu	37	chr18	56402442	56402442	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tctatttttaaggtgtcaagGagcagaagcttttgaaatcc	12	14	9	6	0	2	2	1	1	1	1	3	3	3	3	1	2	2	2	1	2	5	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr18:56402442G>C	uc002lhm.1	+	13	1742	c.1484G>C	c.(1483-1485)GGA>GCA	p.G495A	MALT1_uc002lhn.1_Missense_Mutation_p.G484A	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	495	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						aggtGTCAAGGAGCAGAAGCT	0.169			T	BIRC3	MALT								4	22					0	0	0	0	C	56402442	C	C	56402442	3	2	153	1	0	0	0	0	1	0	0	0	9255	1174	41	2	1534	2	MALT1	18	56402442	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	3473710	56402442	21674806	188	27813											
C3	718	broad.mit.edu	37	chr19	6697749	6697749	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacagagtagggtagccgcaGgtcgatgaagaagtcctgca	13	6	14	8	2	0	3	0	1	0	2	2	4	1	3	2	2	3	4	2	2	5	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:6697749G>A	uc002mfm.2	-	20	2559	c.2497C>T	c.(2497-2499)CTG>TTG	p.L833L		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	833					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GGTAGCCGCAGGTCGATGAAG	0.567													3	33					0	0	0	0	A	6697749	A	A	6697749	2	1	153	1	0	0	0	0	0	0	0	1	2214	991	35	4		4	C3	19	6697749	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08		6697749	52431234	189	27814											
FBN3	84467	broad.mit.edu	37	chr19	8137035	8137035	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagcagctcctctttgtccGgggtgtcctggggtccgggg	3	10	17	11	2	1	1	0	0	1	1	5	1	5	1	4	6	2	2	4	6	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:8137035G>A	uc002mjf.2	-	62	8006	c.7985C>T	c.(7984-7986)CCG>CTG	p.P2662L	FBN3_uc002mje.2_Missense_Mutation_p.P458L	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2662						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CTCTTTGTCCGGGGTGTCCTG	0.662													29	172					0	0	0	0	A	8137035	A	A	8137035	3	1	153	1	0	0	0	0	1	0	0	0	5736	1116	39	1	452	1	FBN3	19	8137035	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1439286	8137035	50991948	190	27815											
ANGPTL6	83854	broad.mit.edu	37	chr19	10204163	10204163	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggttccagggagaagccatCatagtgggcacgtgctccac	9	7	14	11	1	1	1	1	0	0	1	3	2	3	1	3	3	2	3	3	3	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:10204163C>T	uc002mmx.1	-	5	1202	c.1084G>A	c.(1084-1086)GAT>AAT	p.D362N	ANGPTL6_uc002mmy.1_Missense_Mutation_p.D362N	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	362	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			GAGAAGCCATCATAGTGGGCA	0.622													12	58					0	0	0	0	T	10204163	T	T	10204163	3	4	153	1	0	0	0	0	1	0	0	0	618	826	29	2	336	2	ANGPTL6	19	10204163	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	2067128	10204163	48924820	191	27816											
ZGLP1	100125288	broad.mit.edu	37	chr19	10415872	10415872	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagctggagcagcgagtgccGtatttcttgtacctagggtt	7	12	13	9	2	1	0	0	0	1	0	1	2	1	1	2	2	5	5	2	2	3	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:10415872G>A	uc002mnw.3	-	4	1587	c.711C>T	c.(709-711)TAC>TAT	p.Y237Y		NM_001103167	NP_001096637	P0C6A0	ZGLP1_HUMAN	GATA like protein-1	237					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AGCGAGTGCCGTATTTCTTGT	0.562													8	46					0	0	0	0	A	10415872	A	A	10415872	2	1	153	1	0	0	0	0	0	0	0	1	17740	1140	40	1		1	ZGLP1	19	10415872	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	211709	10415872	48713111	192	27817											
ELOF1	84337	broad.mit.edu	37	chr19	11665079	11665079	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggatttctcgtggttgcaGaaggggcaggtgaactgggt	8	10	17	6	1	1	2	0	1	1	1	2	3	1	3	0	6	2	3	0	6	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:11665079G>A	uc002mse.1	-	2	148	c.84C>T	c.(82-84)TTC>TTT	p.F28F	ELOF1_uc002msd.1_Silent_p.F49F	NM_032377	NP_115753	P60002	ELOF1_HUMAN	elongation factor 1 homolog (ELF1, S.	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding				0						CGTGGTTGCAGAAGGGGCAGG	0.572													14	114					0	0	0	0	A	11665079	A	A	11665079	2	1	153	1	0	0	0	0	0	0	0	1	5096	933	33	2		2	ELOF1	19	11665079	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	1249207	11665079	47463904	193	27818											
EMR2	30817	broad.mit.edu	37	chr19	14884783	14884783	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgggggtggtgatgatctCagaaaaagagctgaaccctg	12	8	14	7	0	1	5	1	3	1	2	2	5	1	5	1	3	2	1	1	3	3	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:14884783C>T	uc002mzp.1	-	4	622	c.166G>A	c.(166-168)GAG>AAG	p.E56K	EMR2_uc010xnw.1_Missense_Mutation_p.E56K|EMR2_uc002mzo.1_Missense_Mutation_p.E56K|EMR2_uc002mzq.1_Missense_Mutation_p.E56K|EMR2_uc002mzr.1_Missense_Mutation_p.E56K|EMR2_uc002mzs.1_Missense_Mutation_p.E56K|EMR2_uc002mzt.1_Missense_Mutation_p.E56K|EMR2_uc002mzu.1_Missense_Mutation_p.E56K|EMR2_uc010xnx.1_5'Flank|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	56	Extracellular (Potential).|EGF-like 1.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						GTGATGATCTCAGAAAAAGAG	0.602													29	109					0	0	0	0	T	14884783	T	T	14884783	3	4	153	1	0	0	0	0	1	0	0	0	5129	835	29	2	2377	2	EMR2	19	14884783	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	3219704	14884783	44244200	194	27819											
F2RL3	9002	broad.mit.edu	37	chr19	17000712	17000712	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcgctggcccttcggggaGgccgcctgccgcctggccac	3	5	15	18	4	0	0	0	0	0	0	1	1	0	1	6	5	2	1	6	5	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:17000712G>C	uc002nfa.2	+	2	613	c.438G>C	c.(436-438)GAG>GAC	p.E146D		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	146	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						CCTTCGGGGAGGCCGCCTGCC	0.706													3	11					0	0	0	0	C	17000712	C	C	17000712	3	2	153	1	0	0	0	0	1	0	0	0	5371	991	35	4	444	4	F2RL3	19	17000712	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	2115929	17000712	42128271	195	27820											
ZNF599	148103	broad.mit.edu	37	chr19	35251156	35251156	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggtcttttcctggtccttGagagtcacactcatggagag	7	12	13	9	0	3	2	2	1	1	2	5	4	5	2	2	4	0	0	2	4	0	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:35251156G>C	uc010edn.1	-	4	938	c.550C>G	c.(550-552)CAA>GAA	p.Q184E	ZNF599_uc010edm.1_Missense_Mutation_p.Q147E	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CCTGGTCCTTGAGAGTCACAC	0.473													7	127					0	0	0	0	C	35251156	C	C	35251156	3	2	153	1	0	0	0	0	1	0	0	0	18096	1299	45	2	1220	2	ZNF599	19	35251156	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	18250444	35251156	23877827	196	27821											
LGI4	163175	broad.mit.edu	37	chr19	35616221	35616221	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacggggggccaccagggccGgaggccccagctcctgcagt	6	3	16	16	2	0	0	0	0	0	0	1	1	1	1	6	6	2	2	6	6	0	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:35616221G>A	uc002nxx.2	-	9	2084	c.1490C>T	c.(1489-1491)CCG>CTG	p.P497L	LGI4_uc002nxy.1_Missense_Mutation_p.P325L|LGI4_uc002nxz.1_3'UTR	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	497						extracellular region				pancreas(1)	1	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CACCAGGGCCGGAGGCCCCAG	0.642													10	51					0	0	0	0	A	35616221	A	A	35616221	3	1	153	1	0	0	0	0	1	0	0	0	8795	1116	39	1	127	1	LGI4	19	35616221	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	365065	35616221	23512762	197	27822											
CYP2B6	1555	broad.mit.edu	37	chr19	41522664	41522664	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggccccagaagacatcgatCtgacaccccaggagtgtggt	10	7	12	12	1	1	3	0	1	1	2	2	5	1	4	4	3	0	0	4	3	1	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:41522664C>G	uc002opr.1	+	9	1415	c.1408C>G	c.(1408-1410)CTG>GTG	p.L470V	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.L270V	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	470					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	AGACATCGATCTGACACCCCA	0.582													7	24					0	0	0	0	G	41522664	G	G	41522664	3	3	153	1	0	0	0	0	1	0	0	0	4181	912	32	2	1442	2	CYP2B6	19	41522664	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	5906443	41522664	17606319	198	27823											
POU2F2	5452	broad.mit.edu	37	chr19	42600050	42600050	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctggctgaagtcgttgccgTagagcttgcccatggccagg	6	10	14	11	2	1	2	0	1	1	1	2	2	1	2	3	3	3	4	3	3	2	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:42600050T>C	uc002osp.2	-	9	762	c.695A>G	c.(694-696)TAC>TGC	p.Y232C	POU2F2_uc002osn.2_Missense_Mutation_p.Y216C|POU2F2_uc002oso.2_Missense_Mutation_p.Y5C|POU2F2_uc002osq.2_Missense_Mutation_p.Y216C|POU2F2_uc002osr.1_Missense_Mutation_p.Y232C	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	232	POU-specific.				humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				GTCGTTGCCGTAGAGCTTGCC	0.652													22	105					0	0	0	0	C	42600050	C	C	42600050	3	2	153	1	0	0	0	0	1	0	0	0	12327	1638	57	5	768	5	POU2F2	19	42600050	Missense_Mutation	SNP	T	TCGA-CR-7386-01A-11D-2012-08	1077386	42600050	16528933	199	27824											
TRPM4	54795	broad.mit.edu	37	chr19	49692319	49692319	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccatgcaagctgacgccCgtgccttctttgcccaggat	6	10	11	14	2	1	1	0	1	1	0	1	2	1	2	4	2	4	2	4	2	1	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:49692319C>T	uc002pmw.2	+	14	2062	c.1990C>T	c.(1990-1992)CGT>TGT	p.R664C	TRPM4_uc010emu.2_Missense_Mutation_p.R664C|TRPM4_uc010yak.1_Missense_Mutation_p.R128C|TRPM4_uc002pmx.2_Missense_Mutation_p.R490C|TRPM4_uc010emv.2_Missense_Mutation_p.R549C|TRPM4_uc010yal.1_Missense_Mutation_p.R310C|TRPM4_uc002pmy.2_Missense_Mutation_p.R6C	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	664	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		AGCTGACGCCCGTGCCTTCTT	0.622													25	108					0	0	0	0	T	49692319	T	T	49692319	3	4	153	1	0	0	0	0	1	0	0	0	16655	652	23	1	2044	1	TRPM4	19	49692319	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	7092269	49692319	9436664	200	27825											
RCN3	57333	broad.mit.edu	37	chr19	50042435	50042435	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtccaggtggaggagtacatCggtgagtgggccccaatttc	8	9	15	9	1	0	1	0	1	0	0	3	3	1	3	3	5	1	1	3	5	2	2	rs151007768	byFrequency	TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:50042435C>T	uc002poj.2	+	5	1125	c.678C>T	c.(676-678)ATC>ATT	p.I226I		NM_020650	NP_065701	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	226	EF-hand 4.					endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		AGGAGTACATCGGTGAGTGGG	0.577													7	53					0	0	0	0	T	50042435	T	T	50042435	2	4	153	1	0	0	0	0	0	0	0	1	13246	898	31	1		1	RCN3	19	50042435	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08	350116	50042435	9086548	201	27826											
NLRP7	199713	broad.mit.edu	37	chr19	55450689	55450689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccggaaagcagcttctgtaCgtccccgatgtcccaggcgt	7	9	11	14	4	1	0	0	0	1	0	4	2	4	1	4	2	3	3	4	2	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:55450689C>T	uc002qih.3	-	4	1574	c.1498G>A	c.(1498-1500)GTA>ATA	p.V500I	NLRP7_uc002qig.3_Missense_Mutation_p.V500I|NLRP7_uc002qii.3_Missense_Mutation_p.V500I|NLRP7_uc010esk.2_Missense_Mutation_p.V500I|NLRP7_uc010esl.2_Missense_Mutation_p.V528I	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	500							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AGCTTCTGTACGTCCCCGATG	0.567													11	72					0	0	0	0	T	55450689	T	T	55450689	3	4	153	1	0	0	0	0	1	0	0	0	10536	536	19	1	1647	1	NLRP7	19	55450689	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	5408254	55450689	3678294	202	27827											
ZNF417	147687	broad.mit.edu	37	chr19	58420667	58420667	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaagatttcccatattctcTacactcataaggcctttctc	12	14	3	12	0	3	1	1	0	2	1	6	1	4	1	2	1	1	0	2	1	5	6			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:58420667T>C	uc002qqq.2	-	3	1178	c.979A>G	c.(979-981)AGA>GGA	p.R327G	ZNF417_uc010yhm.1_Missense_Mutation_p.R284G|ZNF417_uc002qqr.2_Missense_Mutation_p.R326G	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	327	C2H2-type 5; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		CCATATTCTCTACACTCATAA	0.463													12	257					0	0	0	0	C	58420667	C	C	58420667	3	2	153	1	0	0	0	0	1	0	0	0	17961	1530	53	5	752	5	ZNF417	19	58420667	Missense_Mutation	SNP	T	TCGA-CR-7386-01A-11D-2012-08	2969978	58420667	708316	203	27828											
TGM6	343641	broad.mit.edu	37	chr20	2378615	2378615	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccatcctggatcgaagccccGgtcaccaaaacaacccagcc	12	4	7	18	2	1	0	1	0	0	0	3	2	2	1	7	2	4	0	7	2	4	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:2378615G>A	uc002wfy.1	+	5	656	c.595G>A	c.(595-597)GGT>AGT	p.G199S	TGM6_uc010gal.1_Missense_Mutation_p.G199S	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	199					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	TCGAAGCCCCGGTCACCAAAA	0.587													6	69					0	0	0	0	A	2378615	A	A	2378615	3	1	153	1	0	0	0	0	1	0	0	0	15900	1116	39	1	613	1	TGM6	20	2378615	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08		2378615	60646905	204	27829											
PAK7	57144	broad.mit.edu	37	chr20	9520219	9520219	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgttgctctctgagagggctCcctcaccaacatcaagtcta	9	11	8	13	0	4	1	2	1	2	1	6	2	5	1	2	1	2	3	2	1	3	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:9520219C>G	uc002wnl.2	-	11	2595	c.2050G>C	c.(2050-2052)GAG>CAG	p.E684Q	PAK7_uc002wnk.2_Missense_Mutation_p.E684Q|PAK7_uc002wnj.2_Missense_Mutation_p.E684Q|PAK7_uc010gby.1_Missense_Mutation_p.E597Q	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	684	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TGAGAGGGCTCCCTCACCAAC	0.507													26	152					0	0	0	0	G	9520219	G	G	9520219	3	3	153	1	0	0	0	0	1	0	0	0	11459	864	30	2	113	2	PAK7	20	9520219	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	7141604	9520219	53505301	205	27830											
CST9	128822	broad.mit.edu	37	chr20	23586433	23586433	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caccaggcataagtcaccagGagctggaagcccatgagaag	14	4	12	11	0	1	1	1	1	0	1	1	4	1	3	3	3	2	2	3	3	3	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:23586433G>C	uc002wtl.2	-	1	178	c.69C>G	c.(67-69)CTC>CTG	p.L23L		NM_001008693	NP_001008693	Q5W186	CST9_HUMAN	cystatin 9 precursor	23						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Colorectal(13;0.0993)					AAGTCACCAGGAGCTGGAAGC	0.532													14	104					0	0	0	0	C	23586433	C	C	23586433	2	2	153	1	0	0	0	0	0	0	0	1	3996	1161	41	2		2	CST9	20	23586433	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	14066214	23586433	39439087	206	27831											
RBM39	9584	broad.mit.edu	37	chr20	34302145	34302145	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaactgaagacgaccagttGttcccaaatcaattccagtc	13	11	6	11	1	1	2	1	1	0	1	4	3	3	2	3	0	1	2	3	0	4	4			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:34302145G>A	uc002xeb.2	-	11	1402	c.1058C>T	c.(1057-1059)ACA>ATA	p.T353I	RBM39_uc002xdz.2_Missense_Mutation_p.T329I|RBM39_uc002xea.2_Missense_Mutation_p.T196I|RBM39_uc010gfn.2_Missense_Mutation_p.T196I|RBM39_uc010zvm.1_Missense_Mutation_p.T331I|RBM39_uc002xeg.2_Missense_Mutation_p.T331I|RBM39_uc002xec.2_Missense_Mutation_p.T353I|RBM39_uc002xed.2_Missense_Mutation_p.T71I|RBM39_uc002xee.2_Missense_Mutation_p.T196I|RBM39_uc002xef.2_Missense_Mutation_p.T196I|RBM39_uc010zvn.1_Missense_Mutation_p.T196I	NM_184234	NP_909122	Q14498	RBM39_HUMAN	RNA binding motif protein 39 isoform a	353	Activating domain (By similarity).|Interaction with JUN (By similarity).				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					ACGACCAGTTGTTCCCAAATC	0.408													8	66					0	0	0	0	A	34302145	A	A	34302145	3	1	153	1	0	0	0	0	1	0	0	0	13198	1377	48	4	562	4	RBM39	20	34302145	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	10715712	34302145	28723375	207	27832											
KIAA1755	85449	broad.mit.edu	37	chr20	36869389	36869389	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cctgagaccagaggcacagtCcagtgcgtcctcaaggacat	11	6	11	13	1	1	2	1	1	0	2	3	4	3	3	4	2	1	1	4	2	1	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:36869389C>G	uc002xhy.1	-	3	1416	c.1144G>C	c.(1144-1146)GAC>CAC	p.D382H	KIAA1755_uc002xhz.1_Missense_Mutation_p.D382H	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	382										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GAGGCACAGTCCAGTGCGTCC	0.547													30	172					0	0	0	0	G	36869389	G	G	36869389	3	3	153	1	0	0	0	0	1	0	0	0	8296	855	30	2	2506	2	KIAA1755	20	36869389	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	2567244	36869389	26156131	208	27833											
GNAS	2778	broad.mit.edu	37	chr20	57429096	57429096	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccagttcgcggcagtcgCggcctcgagtgcggtccgcc	4	6	15	16	7	0	0	0	0	0	0	4	1	1	0	4	3	2	2	4	3	0	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:57429096C>T	uc002xzw.2	+	1	1061	c.776C>T	c.(775-777)GCG>GTG	p.A259V	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GCGGCAGTCGCGGCCTCGAGT	0.667			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			6	28					0	0	0	0	T	57429096	T	T	57429096	3	4	153	1	0	0	0	0	1	0	0	0	6547	768	27	1	1520	1	GNAS	20	57429096	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	20559707	57429096	5596424	209	27834											
ARFRP1	10139	broad.mit.edu	37	chr20	62331810	62331810	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcgcctacgtgatgtccctCtgccgcggcggccggtgcac	3	8	14	16	6	1	1	0	1	1	0	2	1	2	1	4	3	4	1	4	3	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:62331810C>G	uc002yga.2	-	7	1158	c.591G>C	c.(589-591)CAG>CAC	p.Q197H	ARFRP1_uc002ygc.2_Missense_Mutation_p.Q197H|ARFRP1_uc002ygh.3_3'UTR|ARFRP1_uc011abf.1_3'UTR|ARFRP1_uc011abg.1_3'UTR|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Missense_Mutation_p.Q197H|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	197					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			TGATGTCCCTCTGCCGCGGCG	0.682													3	62					0	0	0	0	G	62331810	G	G	62331810	3	3	153	1	0	0	0	0	1	0	0	0	856	912	32	2	18	2	ARFRP1	20	62331810	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	4902714	62331810	693710	210	27835											
SON	6651	broad.mit.edu	37	chr21	34923116	34923116	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacggtggaacatcctgggCatcctgaggtgacaacggca	11	6	13	11	2	0	2	0	2	0	0	2	3	2	3	2	5	3	2	2	5	3	0			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr21:34923116C>T	uc002yse.1	+	3	1628	c.1579C>T	c.(1579-1581)CAT>TAT	p.H527Y	SON_uc002ysb.1_Missense_Mutation_p.H527Y|SON_uc002ysc.2_Missense_Mutation_p.H527Y|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	527					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						ACATCCTGGGCATCCTGAGGT	0.592													21	125					0	0	0	0	T	34923116	T	T	34923116	3	4	153	1	0	0	0	0	1	0	0	0	14990	710	25	4	1589	4	SON	21	34923116	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08		34923116	13206779	211	27836											
TTC3	7267	broad.mit.edu	37	chr21	38525425	38525425	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacaacctgtttttctagcaGaaattttctaaatgaagcag	14	14	6	7	0	2	2	0	1	2	1	2	2	2	2	1	0	4	3	1	0	7	7			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr21:38525425G>C	uc002yvz.2	+	27	2693	c.2588G>C	c.(2587-2589)AGA>ACA	p.R863T	TTC3_uc011aee.1_Missense_Mutation_p.R553T|TTC3_uc002ywa.2_Missense_Mutation_p.R863T|TTC3_uc002ywb.2_Missense_Mutation_p.R863T|TTC3_uc010gnf.2_Missense_Mutation_p.R628T|TTC3_uc002ywc.2_Missense_Mutation_p.R553T|TTC3_uc011aed.1_Missense_Mutation_p.R553T	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	863					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TTTTCTAGCAGAAATTTTCTA	0.348													18	86					0	0	0	0	C	38525425	C	C	38525425	3	2	153	1	0	0	0	0	1	0	0	0	16765	942	33	2	2690	2	TTC3	21	38525425	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	3602309	38525425	9604470	212	27837											
MYH9	4627	broad.mit.edu	37	chr22	36708234	36708234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttggggaaccagcactcctCgtccagcagggccagaatgc	9	7	12	13	1	0	1	0	0	0	1	3	2	2	2	4	3	4	2	4	3	2	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr22:36708234C>T	uc003apg.2	-	14	1819	c.1588G>A	c.(1588-1590)GAG>AAG	p.E530K	MYH9_uc003aph.1_Missense_Mutation_p.E394K	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	530	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CAGCACTCCTCGTCCAGCAGG	0.637			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				12	65					0	0	0	0	T	36708234	T	T	36708234	3	4	153	1	0	0	0	0	1	0	0	0	10095	893	31	1	4406	1	MYH9	22	36708234	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08		36708234	14596332	213	27838											
DCAF8L1	139425	broad.mit.edu	37	chrX	27999311	27999311	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtatcaccaccatctccggtCgatggctctgtggctgccat	6	11	10	14	2	3	0	1	0	2	0	5	1	3	0	4	3	1	3	4	3	1	1			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:27999311C>G	uc004dbx.1	-	1	256	c.141G>C	c.(139-141)TCG>TCC	p.S47S		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	47										ovary(3)|skin(1)	4						CATCTCCGGTCGATGGCTCTG	0.532													9	28					0	0	0	0	G	27999311	G	G	27999311	2	3	153	1	0	0	0	0	0	0	0	1	4294	871	31	3		3	DCAF8L1	23	27999311	Silent	SNP	C	TCGA-CR-7386-01A-11D-2012-08		27999311	127271249	214	27839											
XK	7504	broad.mit.edu	37	chrX	37587032	37587032	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttcctgtggaggagctttGagattgccactcgagttgta	7	14	12	8	1	1	1	0	1	1	1	3	5	2	3	2	2	2	3	2	2	1	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:37587032G>C	uc004ddq.2	+	3	734	c.652G>C	c.(652-654)GAG>CAG	p.E218Q		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	218	Helical; (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				GAGGAGCTTTGAGATTGCCAC	0.458													8	17					0	0	0	0	C	37587032	C	C	37587032	3	2	153	1	0	0	0	0	1	0	0	0	17499	1291	45	2	662	2	XK	23	37587032	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	9587721	37587032	117683528	215	27840											
SHROOM4	57477	broad.mit.edu	37	chrX	50377069	50377069	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggctctcaggggcttggctGaggcactcggaagacctagc	7	8	15	11	1	1	2	1	1	1	1	3	3	1	3	1	6	1	4	1	6	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:50377069G>A	uc004dpe.2	-	4	2030	c.2004C>T	c.(2002-2004)CTC>CTT	p.L668L	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Silent_p.L552L	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	668					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GGGCTTGGCTGAGGCACTCGG	0.527													7	15					0	0	0	0	A	50377069	A	A	50377069	2	1	153	1	0	0	0	0	0	0	0	1	14361	1277	45	2		2	SHROOM4	23	50377069	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	12790037	50377069	104893491	216	27841			1	42		3	3	788	G		1.584646e-05
SHROOM4	57477	broad.mit.edu	37	chrX	50377082	50377082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttggctgaggcactcggaaGacctagctctgagcatcatg	9	9	12	11	1	2	3	1	2	1	1	3	4	2	4	1	3	2	4	1	3	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:50377082G>A	uc004dpe.2	-	4	2017	c.1991C>T	c.(1990-1992)TCT>TTT	p.S664F	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.S548F	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	664					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GCACTCGGAAGACCTAGCTCT	0.532													9	17					0	0	0	0	A	50377082	A	A	50377082	3	1	153	1	0	0	0	0	1	0	0	0	14361	942	33	2	2514	2	SHROOM4	23	50377082	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	13	50377082	104893478	217	27842			1	42		3	3	788	G		1.584646e-05
SHROOM4	57477	broad.mit.edu	37	chrX	50377856	50377856	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcactatggcgatgccctGtgggtcctatgagatgtgga	7	10	16	8	1	0	1	0	1	0	1	1	4	1	2	2	4	1	1	2	4	2	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:50377856G>C	uc004dpe.2	-	4	1243	c.1217C>G	c.(1216-1218)ACA>AGA	p.T406R	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.T290R	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	406					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GCGATGCCCTGTGGGTCCTAT	0.567													5	11					0	0	0	0	C	50377856	C	C	50377856	3	2	153	1	0	0	0	0	1	0	0	0	14361	1377	48	4	3288	4	SHROOM4	23	50377856	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	774	50377856	104892704	218	27843			1	42		3	3	788	G		1.584646e-05
ATP7A	538	broad.mit.edu	37	chrX	77243873	77243873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accctctccctgttttaactGacaccttgtttctgactgtt	6	17	5	13	0	2	2	0	2	2	0	3	2	2	2	3	0	1	3	3	0	1	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:77243873G>A	uc004ecx.3	+	3	416	c.256G>A	c.(256-258)GAC>AAC	p.D86N	ATP7A_uc004ecw.2_Missense_Mutation_p.D86N	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	86	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TGTTTTAACTGACACCTTGTT	0.443													72	166					0	0	0	0	A	77243873	A	A	77243873	3	1	153	1	0	0	0	0	1	0	0	0	1192	1290	45	2	262	2	ATP7A	23	77243873	Missense_Mutation	SNP	G	TCGA-CR-7386-01A-11D-2012-08	26866017	77243873	78026687	219	27844											
MID2	11043	broad.mit.edu	37	chrX	107169397	107169397	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgatggattgcagatggaGaaggatgaaagctctctaaa	16	9	12	4	0	1	4	0	2	1	2	2	7	1	6	0	3	2	2	0	3	5	2			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:107169397G>A	uc004enl.2	+	9	2244	c.1671G>A	c.(1669-1671)GAG>GAA	p.E557E	MID2_uc004enk.2_Silent_p.E527E	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	557	B30.2/SPRY.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						TGCAGATGGAGAAGGATGAAA	0.423													19	51					0	0	0	0	A	107169397	A	A	107169397	2	1	153	1	0	0	0	0	0	0	0	1	9631	933	33	2		2	MID2	23	107169397	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	29925524	107169397	48101163	220	27845											
AFF2	2334	broad.mit.edu	37	chrX	148059934	148059934	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatttgagaatgtttaagctGaagaaggaccatgctatgaa	15	12	10	4	0	0	4	0	3	0	2	0	6	0	5	1	1	2	3	1	1	7	5			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:148059934G>A	uc004fcp.2	+	18	3998	c.3519G>A	c.(3517-3519)CTG>CTA	p.L1173L	AFF2_uc004fcq.2_Silent_p.L1163L|AFF2_uc004fcr.2_Silent_p.L1134L|AFF2_uc011mxb.1_Silent_p.L1138L|AFF2_uc004fcs.2_Silent_p.L1138L|AFF2_uc011mxc.1_Silent_p.L814L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1173					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TGTTTAAGCTGAAGAAGGACC	0.348													10	43					0	0	0	0	A	148059934	A	A	148059934	2	1	153	1	0	0	0	0	0	0	0	1	357	1277	45	2		2	AFF2	23	148059934	Silent	SNP	G	TCGA-CR-7386-01A-11D-2012-08	40890537	148059934	7210626	221	27846											
FAM3A	60343	broad.mit.edu	37	chrX	153735753	153735753	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctacttggtggctgggtcgtCgtaggatgccacgaacacca	8	9	13	11	3	0	0	0	0	0	0	2	2	0	1	2	4	3	2	2	4	3	3			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:153735753C>T	uc004fls.1	-	7	731	c.454G>A	c.(454-456)GAC>AAC	p.D152N	FAM3A_uc004flt.1_Missense_Mutation_p.D166N|FAM3A_uc011mzp.1_Missense_Mutation_p.D135N|FAM3A_uc004flu.1_Missense_Mutation_p.D149N|FAM3A_uc011mzq.1_Missense_Mutation_p.D152N|FAM3A_uc004flw.1_Missense_Mutation_p.D152N	NM_021806	NP_068578	P98173	FAM3A_HUMAN	family 3, member A protein precursor	152						extracellular region				large_intestine(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTGGGTCGTCGTAGGATGCC	0.602													8	16					0	0	0	0	T	153735753	T	T	153735753	3	4	153	1	0	0	0	0	1	0	0	0	5588	884	31	1	250	1	FAM3A	23	153735753	Missense_Mutation	SNP	C	TCGA-CR-7386-01A-11D-2012-08	5675819	153735753	1534807	222	27847											
SAMD11	148398	broad.mit.edu	37	chr1	871231	871231	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccgagcatcagagccgcTgtgaattccagagaggcagc	10	6	13	12	2	1	3	1	1	0	2	2	5	2	3	3	1	4	3	3	1	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:871231T>A	uc001abw.1	+	5	465	c.385T>A	c.(385-387)TGT>AGT	p.C129S	SAMD11_uc001abv.1_Missense_Mutation_p.C129S|SAMD11_uc001abx.1_Missense_Mutation_p.C8S	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	129				C -> L (in Ref. 2; AAH24295).		nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		TCAGAGCCGCTGTGAATTCCA	0.672													24	70					0	0	0	0	A	871231	A	A	871231	3	1	154	1	0	0	0	0	1	0	0	0	13881	1580	55	5	399	5	SAMD11	1	871231	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08		871231	248379390	1	27848											
PLEKHN1	84069	broad.mit.edu	37	chr1	901962	901964	+	In_Frame_Del	DEL	CTT	-	-																															cccaggaggctccgggcctcCttctccagaaagccctcgct																								rs146294016		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:901962_901964delCTT	uc001ace.2	+	1	86_88	c.51_53delCTT	c.(49-54)TCCTTC>TCC	p.F18del	PLEKHN1_uc001acd.2_In_Frame_Del_p.F18del|PLEKHN1_uc001acf.2_In_Frame_Del_p.F18del	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	18											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		TCCGGGCCTCCTTCTCCAGAAAG	0.69													---	---	---								-	901964	-	-	901962	7	5	154	1	0	1	0	1	0	0	0	0	12138	668	24	0	53	0	PLEKHN1	1	901962	In_Frame_Del	DEL	CTT	TCGA-CR-7388-01A-11D-2012-08	30731	901962	248348659	2	27849											
ICMT	23463	broad.mit.edu	37	chr1	6291999	6291999	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtaaaaccacccgacgtaaGaaggatgccgaaaccaagcg	17	3	10	11	4	0	1	0	0	0	1	0	4	0	2	4	1	4	2	4	1	6	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:6291999G>C	uc001amk.2	-	4	708	c.635C>G	c.(634-636)TCT>TGT	p.S212C	ICMT_uc001aml.2_Missense_Mutation_p.S116C	NM_012405	NP_036537	O60725	ICMT_HUMAN	isoprenylcysteine carboxyl methyltransferase	212					protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;2.4e-22)|all_lung(118;2.65e-08)|Lung NSC(185;6.45e-07)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000688)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;5.52e-38)|GBM - Glioblastoma multiforme(13;6.51e-32)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;7.08e-08)|COAD - Colon adenocarcinoma(227;8.35e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CCCGACGTAAGAAGGATGCCG	0.348													3	51					0	0	0	0	C	6291999	C	C	6291999	3	2	154	1	0	0	0	0	1	0	0	0	7524	942	33	2	227	2	ICMT	1	6291999	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5390037	6291999	242958622	3	27850											
TNFRSF9	3604	broad.mit.edu	37	chr1	7999954	7999954	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acatgataactgggtactcaCcagctgggcagttactacaa	13	9	9	10	0	1	1	1	1	0	0	1	1	1	1	1	2	5	4	1	2	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:7999954C>T	uc001aot.2	-	2	228	c.100_splice	c.e2+1	p.G34_splice		NM_001561	NP_001552	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily,						induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		TGGGTACTCACCAGCTGGGCA	0.453													21	48					0	0	0	0	T	7999954	T	T	7999954	5	4	154	1	0	0	0	0	0	0	1	0	16366	521	18	4	694	4	TNFRSF9	1	7999954	Splice_Site	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1707955	7999954	241250667	4	27851											
PEX14	5195	broad.mit.edu	37	chr1	10659315	10659315	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctgacagatgaagagattGatatggccttccagcagtcg	11	9	13	8	1	0	5	0	3	0	2	2	6	1	5	2	2	1	2	2	2	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:10659315G>A	uc001arn.2	+	4	211	c.190G>A	c.(190-192)GAT>AAT	p.D64N	PEX14_uc009vmu.1_Intron|PEX14_uc009vmv.2_5'UTR|PEX14_uc010oam.1_5'UTR|PEX14_uc010oan.1_Intron|PEX14_uc009vmw.2_5'UTR	NM_004565	NP_004556	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	64					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(1)	1	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		TGAAGAGATTGATATGGCCTT	0.542													11	94					0	0	0	0	A	10659315	A	A	10659315	3	1	154	1	0	0	0	0	1	0	0	0	11797	1290	45	2	204	2	PEX14	1	10659315	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2659361	10659315	238591306	5	27852											
MTOR	2475	broad.mit.edu	37	chr1	11206848	11206848	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttccatgctgtcccactgaCctatacacacacacatagac	12	9	4	16	0	0	2	0	1	0	1	2	2	2	2	3	0	2	1	3	0	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:11206848C>A	uc001asd.2	-	32	4692	c.4571G>T	c.(4570-4572)GGT>GTT	p.G1524V		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1524	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						GTCCCACTGACCTATACACAC	0.488													18	40					1.33834e-09	2.95207e-09	1	0	A	11206848	A	A	11206848	3	1	154	1	0	0	0	0	1	0	0	0	10007	521	18	4	3186	4	MTOR	1	11206848	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	547533	11206848	238043773	6	27853											
UBIAD1	29914	broad.mit.edu	37	chr1	11334044	11334044	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgcttgcctctactacctGtcccctctgaaactggagca	7	10	8	16	1	2	1	0	1	2	0	3	2	3	2	5	1	5	2	5	1	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:11334044G>C	uc001asg.2	+	1	790	c.456G>C	c.(454-456)CTG>CTC	p.L152L		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	152	Helical; (Potential).				menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		TCTACTACCTGTCCCCTCTGA	0.557													8	57					0	0	0	0	C	11334044	C	C	11334044	2	2	154	1	0	0	0	0	0	0	0	1	16953	1364	48	4		4	UBIAD1	1	11334044	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	127196	11334044	237916577	7	27854											
AADACL4	343066	broad.mit.edu	37	chr1	12726424	12726424	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	taagaacagaggctaccaacCctggtctcccggccctttta	10	9	8	14	1	1	2	0	0	1	2	2	2	1	2	4	3	3	1	4	3	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:12726424C>T	uc001auf.2	+	4	902	c.902C>T	c.(901-903)CCC>CTC	p.P301L		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	301	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GGCTACCAACCCTGGTCTCCC	0.493													28	92					0	0	0	0	T	12726424	T	T	12726424	3	4	154	1	0	0	0	0	1	0	0	0	13	623	22	4	916	4	AADACL4	1	12726424	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1392380	12726424	236524197	8	27855											
NBPF1	55672	broad.mit.edu	37	chr1	16907918	16907918	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgagtattcagtgttacctgGgggcagatgattccagtact	9	13	12	7	0	1	3	1	2	0	1	2	3	2	3	2	2	2	4	2	2	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:16907918G>T	uc009vos.1	-	15	2264	c.1376C>A	c.(1375-1377)CCC>CAC	p.P459H	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Intron|NBPF1_uc010oce.1_Missense_Mutation_p.P188H	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	459	NBPF 2.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GTGTTACCTGGGGGCAGATGA	0.433													9	481					0.000219431	0.000425315	1	0	T	16907918	T	T	16907918	3	4	154	1	0	0	0	0	1	0	0	0	10245	1232	43	4	2108	4	NBPF1	1	16907918	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4181494	16907918	232342703	9	27856											
PAX7	5081	broad.mit.edu	37	chr1	19062184	19062184	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagccacaggctgacttctCcatctccccgctgcatggcg	6	8	10	17	2	2	1	0	1	2	0	4	1	2	1	4	2	2	4	4	2	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:19062184C>A	uc001bay.2	+	8	1812	c.1214C>A	c.(1213-1215)TCC>TAC	p.S405Y	PAX7_uc001baz.2_Missense_Mutation_p.S403Y|PAX7_uc010oct.1_Missense_Mutation_p.S405Y	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	405					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		GCTGACTTCTCCATCTCCCCG	0.657			T	FOXO1A	alveolar rhabdomyosarcoma								21	65					3.51602e-12	8.11175e-12	1	0	A	19062184	A	A	19062184	3	1	154	1	0	0	0	0	1	0	0	0	11538	855	30	2	1244	2	PAX7	1	19062184	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2154266	19062184	230188437	10	27857											
ALPL	249	broad.mit.edu	37	chr1	21889671	21889671	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctacctgtgtggggtgaaGgccaatgagggcaccgtggg	7	7	18	9	1	0	2	0	2	0	0	0	2	0	2	4	5	1	1	4	5	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:21889671G>T	uc001bet.2	+	5	623	c.366G>T	c.(364-366)AAG>AAT	p.K122N	ALPL_uc010odn.1_Missense_Mutation_p.K70N|ALPL_uc010odo.1_Missense_Mutation_p.K67N|ALPL_uc010odp.1_Missense_Mutation_p.K45N|ALPL_uc001beu.3_Missense_Mutation_p.K122N	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	122					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	GTGGGGTGAAGGCCAATGAGG	0.657													13	66					0.000151284	0.000294854	1	0	T	21889671	T	T	21889671	3	4	154	1	0	0	0	0	1	0	0	0	547	991	35	4	380	4	ALPL	1	21889671	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2827487	21889671	227360950	11	27858											
E2F2	1870	broad.mit.edu	37	chr1	23848419	23848419	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgcgccgcttctgcacgTccagcacctcagcggcccag	7	6	11	17	4	2	1	1	0	1	1	3	1	3	1	4	1	4	3	4	1	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:23848419T>C	uc001bhe.1	-	3	916	c.488A>G	c.(487-489)GAC>GGC	p.D163G		NM_004091	NP_004082	Q14209	E2F2_HUMAN	E2F transcription factor 2	163	Leucine-zipper.|DEF box.|Potential.				G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|skin(2)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		CTTCTGCACGTCCAGCACCTC	0.567													4	71					0	0	0	0	C	23848419	C	C	23848419	3	2	154	1	0	0	0	0	1	0	0	0	4889	1667	58	5	845	5	E2F2	1	23848419	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1958748	23848419	225402202	12	27859											
HMGCL	3155	broad.mit.edu	37	chr1	24137224	24137224	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccctgacacatgcacacAcctcagctactttagctggg	9	8	8	16	1	1	1	1	1	0	0	1	1	1	1	3	1	4	3	3	1	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:24137224A>C	uc001bib.2	-	6	605	c.561_splice	c.e6+1	p.E187_splice	HMGCL_uc010oec.1_Intron|HMGCL_uc009vqr.2_Intron|HMGCL_uc001bic.2_Splice_Site_p.E162_splice|HMGCL_uc009vqs.1_Intron|HMGCL_uc001bid.1_Missense_Mutation_p.V188G	NM_000191	NP_000182	P35914	HMGCL_HUMAN	3-hydroxy-3-methylglutaryl CoA lyase isoform 1						acetoacetic acid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA lyase activity|metal ion binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.0044)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.38e-24)|Colorectal(126;5.58e-08)|COAD - Colon adenocarcinoma(152;3.12e-06)|GBM - Glioblastoma multiforme(114;4.9e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000982)|KIRC - Kidney renal clear cell carcinoma(1967;0.0034)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0856)|LUSC - Lung squamous cell carcinoma(448;0.188)		ACATGCACACACCTCAGCTAC	0.582											OREG0013233	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	22					0	0	0	0	C	24137224	C	C	24137224	5	2	154	1	0	0	0	0	0	0	1	0	7268	173	6	5	430	5	HMGCL	1	24137224	Splice_Site	SNP	A	TCGA-CR-7388-01A-11D-2012-08	288805	24137224	225113397	13	27860											
ZNF683	257101	broad.mit.edu	37	chr1	26691026	26691026	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccaggaggcagataccttGagattggagagctgcccaaa	12	6	13	10	0	0	3	0	1	0	3	0	6	0	4	3	3	3	2	3	3	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:26691026G>C	uc001bmg.1	-	4	1129	c.1011C>G	c.(1009-1011)CTC>CTG	p.L337L	ZNF683_uc001bmh.1_Silent_p.L337L|ZNF683_uc009vsj.1_Silent_p.L337L	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	337	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		CAGATACCTTGAGATTGGAGA	0.537													34	131					0	0	0	0	C	26691026	C	C	26691026	2	2	154	1	0	0	0	0	0	0	0	1	18157	1277	45	2		2	ZNF683	1	26691026	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2553802	26691026	222559595	14	27861											
ARID1A	8289	broad.mit.edu	37	chr1	27092740	27092740	+	Frame_Shift_Del	DEL	G	-	-																															gctaccccaatatgaatcaaGggggcatgatgggaactgga																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:27092740delG	uc001bmv.1	+	9	3134	c.2761delG	c.(2761-2763)GGGfs	p.G921fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.G921fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.G921fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.G538fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	921					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TATGAATCAAGGGGGCATGAT	0.483			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								---	---	---								-	27092740	-	-	27092740	7	5	154	1	0	1	0	1	0	0	0	0	913	1000	35	0	2795	0	ARID1A	1	27092740	Frame_Shift_Del	DEL	G	TCGA-CR-7388-01A-11D-2012-08	401714	27092740	222157881	15	27862											
AHDC1	27245	broad.mit.edu	37	chr1	27878118	27878118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgttggccaaactgggtGaggagaagaagctgtactgt	10	10	15	6	0	0	3	0	1	0	2	0	4	0	3	1	3	4	4	1	3	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:27878118G>A	uc009vsy.2	-	6	1478	c.509C>T	c.(508-510)TCA>TTA	p.S170L	AHDC1_uc009vsz.1_Missense_Mutation_p.S170L|AHDC1_uc001boh.1_Missense_Mutation_p.S43L	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	170	Pro-rich.						DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CAAACTGGGTGAGGAGAAGAA	0.662													6	127					0	0	0	0	A	27878118	A	A	27878118	3	1	154	1	0	0	0	0	1	0	0	0	412	1294	45	2	4306	2	AHDC1	1	27878118	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	785378	27878118	221372503	16	27863											
PTPRU	10076	broad.mit.edu	37	chr1	29652139	29652139	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacttttgctacgatgtggCcctggagtacttggaggggc	6	11	14	10	1	0	0	0	0	0	0	0	3	0	2	2	5	3	2	2	5	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:29652139C>T	uc001bru.2	+	31	4417	c.4307C>T	c.(4306-4308)GCC>GTC	p.A1436V	PTPRU_uc001brv.2_Missense_Mutation_p.A1432V|PTPRU_uc001brw.2_Missense_Mutation_p.A1426V|PTPRU_uc009vtq.2_Missense_Mutation_p.A1430V|PTPRU_uc009vtr.2_Missense_Mutation_p.A1423V|PTPRU_uc001brx.2_Missense_Mutation_p.A162V	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1436	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).			A -> V (in Ref. 5; AAB07074).	canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		TACGATGTGGCCCTGGAGTAC	0.622													13	72					0	0	0	0	T	29652139	T	T	29652139	3	4	154	1	0	0	0	0	1	0	0	0	12878	739	26	4	4451	4	PTPRU	1	29652139	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1774021	29652139	219598482	17	27864											
PUM1	9698	broad.mit.edu	37	chr1	31414879	31414879	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtgctggtgaagctccTctaaaatagggagtgtctgg	8	12	14	7	0	2	1	0	1	2	0	3	2	3	2	1	3	2	2	1	3	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:31414879T>A	uc001bsi.1	-	19	3193	c.3080A>T	c.(3079-3081)GAG>GTG	p.E1027V	PUM1_uc001bsf.1_Missense_Mutation_p.E695V|PUM1_uc001bsg.1_Missense_Mutation_p.E761V|PUM1_uc001bsh.1_Missense_Mutation_p.E1029V|PUM1_uc001bsj.1_Missense_Mutation_p.E1003V|PUM1_uc010oga.1_Missense_Mutation_p.E885V|PUM1_uc001bsk.1_Missense_Mutation_p.E1065V|PUM1_uc010ogb.1_Missense_Mutation_p.E968V|SNORD103A_uc009vts.1_Intron	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	1027	PUM-HD.|Pumilio 5.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		GTGAAGCTCCTCTAAAATAGG	0.517													27	117					0	0	0	0	A	31414879	A	A	31414879	3	1	154	1	0	0	0	0	1	0	0	0	12890	1551	54	5	496	5	PUM1	1	31414879	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1762740	31414879	217835742	18	27865											
EIF2C1	26523	broad.mit.edu	37	chr1	36367879	36367879	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctacaatgggattgagatCaaagtctgggccatcgcctg	10	11	11	9	1	3	1	1	1	2	1	4	3	3	2	2	2	1	0	2	2	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:36367879C>G	uc001bzl.2	+	11	1551	c.1338C>G	c.(1336-1338)ATC>ATG	p.I446M	EIF2C1_uc001bzk.2_Missense_Mutation_p.I371M|EIF2C1_uc009vuy.2_Intron	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	446					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GGATTGAGATCAAAGTCTGGG	0.572													4	83					0	0	0	0	G	36367879	G	G	36367879	3	3	154	1	0	0	0	0	1	0	0	0	5027	816	29	2	1380	2	EIF2C1	1	36367879	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4953000	36367879	212882742	19	27866											
THRAP3	9967	broad.mit.edu	37	chr1	36755352	36755352	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccggatggactcttttgatGaggacctcgcacggtgagat	8	11	13	9	3	1	3	0	3	1	1	3	7	2	6	2	4	0	1	2	4	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:36755352G>A	uc001cae.3	+	5	1956	c.1732G>A	c.(1732-1734)GAG>AAG	p.E578K	THRAP3_uc001caf.3_Missense_Mutation_p.E578K|THRAP3_uc001cag.1_Missense_Mutation_p.E578K	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	578					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTCTTTTGATGAGGACCTCGC	0.512			T	USP6	aneurysmal bone cysts								5	48					0	0	0	0	A	36755352	A	A	36755352	3	1	154	1	0	0	0	0	1	0	0	0	15940	1291	45	2	1742	2	THRAP3	1	36755352	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	387473	36755352	212495269	20	27867											
PARS2	25973	broad.mit.edu	37	chr1	55224789	55224789	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagagctggcggctgcaggTggccagggcgggcaatgctc	7	5	19	10	2	0	1	0	0	0	1	1	2	0	1	1	6	3	5	1	6	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:55224789T>A	uc001cxy.2	-	2	129	c.46A>T	c.(46-48)ACC>TCC	p.T16S		NM_152268	NP_689481	Q7L3T8	SYPM_HUMAN	prolyl-tRNA synthetase (mitochondrial)(putative)	16					prolyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|proline-tRNA ligase activity			ovary(2)	2					L-Proline(DB00172)	CGGCTGCAGGTGGCCAGGGCG	0.597													5	25					0	0	0	0	A	55224789	A	A	55224789	3	1	154	1	0	0	0	0	1	0	0	0	11521	1696	59	5	1385	5	PARS2	1	55224789	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	18469437	55224789	194025832	21	27868											
C8A	731	broad.mit.edu	37	chr1	57378249	57378249	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaccagctgcaggtgccaGtgccgcctgggtagcttggg	5	7	17	12	1	0	0	0	0	0	0	0	0	0	0	4	4	5	5	4	4	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:57378249G>T	uc001cyo.2	+	10	1686	c.1554G>T	c.(1552-1554)CAG>CAT	p.Q518H		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	518	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GCAGGTGCCAGTGCCGCCTGG	0.602													21	69					1.50039e-11	3.40786e-11	1	0	T	57378249	T	T	57378249	3	4	154	1	0	0	0	0	1	0	0	0	2427	1020	36	4	1592	4	C8A	1	57378249	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2153460	57378249	191872372	22	27869											
SLC35D1	23169	broad.mit.edu	37	chr1	67507918	67507918	+	Splice_Site	DEL	C	-	-																															accgtaattagaaagtcctaCcttttgtgcatctcctgtga																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:67507918delC	uc001ddk.2	-	8	1113	c.729_splice	c.e8+1	p.K243_splice	SLC35D1_uc010oph.1_Splice_Site_p.K164_splice	NM_015139	NP_055954	Q9NTN3	S35D1_HUMAN	solute carrier family 35 (UDP-glucuronic						chondroitin sulfate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity				0					Lorazepam(DB00186)	GAAAGTCCTACCTTTTGTGCA	0.383													---	---	---								-	67507918	-	-	67507918	8	5	154	1	0	1	0	1	0	0	1	0	14645	521	18	0	357	0	SLC35D1	1	67507918	Splice_Site	DEL	C	TCGA-CR-7388-01A-11D-2012-08	10129669	67507918	181742703	23	27870											
C1orf141	400757	broad.mit.edu	37	chr1	67558779	67558779	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatatatttaaaaggctttGagtaacatttgacaggtaag	16	14	8	3	0	0	2	0	2	0	0	0	2	0	2	0	2	1	3	0	2	7	9			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:67558779G>C	uc001ddl.1	-	7	1223	c.1112C>G	c.(1111-1113)TCA>TGA	p.S371*	C1orf141_uc001ddm.1_Nonsense_Mutation_p.S371*|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	371										ovary(1)	1						AAAAGGCTTTGAGTAACATTT	0.318													8	59					0	0	0	0	C	67558779	C	C	67558779	4	2	154	1	0	0	0	0	0	1	0	0	2010	1294	45	2	94	2	C1orf141	1	67558779	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	50861	67558779	181691842	24	27871											
LRRIQ3	127255	broad.mit.edu	37	chr1	74507579	74507579	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgatatcctaaaactggtatCcaatttttcatccacaattt	13	16	3	9	0	1	1	1	1	0	0	4	1	4	1	3	1	1	1	3	1	6	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:74507579C>A	uc001dfy.3	-	7	1228	c.1036G>T	c.(1036-1038)GAT>TAT	p.D346Y	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	346										ovary(2)	2						AAACTGGTATCCAATTTTTCA	0.308													12	39					4.36969e-10	9.73627e-10	1	0	A	74507579	A	A	74507579	3	1	154	1	0	0	0	0	1	0	0	0	9080	855	30	2	846	2	LRRIQ3	1	74507579	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6948800	74507579	174743042	25	27872											
C1orf173	127254	broad.mit.edu	37	chr1	75036823	75036823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agacctgcacgttgttggggGaaacatctgcagtctcgctt	8	11	12	10	2	2	1	0	0	2	1	3	2	2	2	1	2	3	5	1	2	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:75036823G>A	uc001dgg.2	-	14	4790	c.4571C>T	c.(4570-4572)TCC>TTC	p.S1524F		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1524										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTTGTTGGGGGAAACATCTGC	0.512													19	114					0	0	0	0	A	75036823	A	A	75036823	3	1	154	1	0	0	0	0	1	0	0	0	2023	1174	41	2	25	2	C1orf173	1	75036823	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	529244	75036823	174213798	26	27873											
C1orf173	127254	broad.mit.edu	37	chr1	75037379	75037379	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tccgtgtagaacttccacagCcacaacccttcctcctccca	9	9	4	19	1	0	1	0	0	0	1	5	1	5	1	7	0	3	1	7	0	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:75037379C>G	uc001dgg.2	-	14	4234	c.4015G>C	c.(4015-4017)GCT>CCT	p.A1339P		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1339	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						ACTTCCACAGCCACAACCCTT	0.557													29	84					0	0	0	0	G	75037379	G	G	75037379	3	3	154	1	0	0	0	0	1	0	0	0	2023	739	26	4	581	4	C1orf173	1	75037379	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	556	75037379	174213242	27	27874											
USP33	23032	broad.mit.edu	37	chr1	78200086	78200086	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacaagtatttccaatatttTtcaaacctgtaagacctatt	15	15	3	8	0	1	1	1	0	0	1	2	1	2	1	3	0	2	2	3	0	8	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:78200086T>C	uc001dht.2	-	8	910	c.563A>G	c.(562-564)AAA>AGA	p.K188R	USP33_uc001dhu.2_Missense_Mutation_p.K157R|USP33_uc001dhv.2_5'UTR|USP33_uc001dhw.2_Missense_Mutation_p.K188R	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	188					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						TCCAATATTTTTCAAACCTGT	0.249													5	20					0	0	0	0	C	78200086	C	C	78200086	3	2	154	1	0	0	0	0	1	0	0	0	17132	1841	64	5	2349	5	USP33	1	78200086	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	3162707	78200086	171050535	28	27875											
SPATA1	64173	broad.mit.edu	37	chr1	84991680	84991680	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaattagtgtaactttgttCaaggaggaacttggaagaga	14	11	11	5	0	1	1	1	0	0	1	1	5	1	4	1	3	2	2	1	3	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:84991680C>A	uc001djz.1	+	6	733	c.534C>A	c.(532-534)TTC>TTA	p.F178L	SPATA1_uc001djx.2_Missense_Mutation_p.F178L|SPATA1_uc001djy.1_RNA	NM_001081472	NP_001074941			spermatogenesis associated 1											central_nervous_system(1)	1				Epithelial(280;4.36e-10)|all cancers(265;7.1e-09)|BRCA - Breast invasive adenocarcinoma(282;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(397;0.00286)|KIRC - Kidney renal clear cell carcinoma(1967;0.0111)		TAACTTTGTTCAAGGAGGAAC	0.373													6	33					1.12685e-05	2.25627e-05	1	0	A	84991680	A	A	84991680	3	1	154	1	0	0	0	0	1	0	0	0	15064	825	29	2	552	2	SPATA1	1	84991680	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6791594	84991680	164258941	29	27876											
BCL10	8915	broad.mit.edu	37	chr1	85733496	85733496	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttctagaacaggcaaattCagagaagaattagtagaaaa	20	8	8	5	0	2	4	1	0	1	4	2	5	2	4	0	1	1	2	0	1	9	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:85733496C>T	uc001dkz.2	-	4	1221	c.516G>A	c.(514-516)CTG>CTA	p.L172L		NM_003921	NP_003912	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	172					apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			lung(2)	2				all cancers(265;0.0114)|Epithelial(280;0.0311)		CAGGCAAATTCAGAGAAGAAT	0.463			T	IGH@	MALT 								14	55					0	0	0	0	T	85733496	T	T	85733496	2	4	154	1	0	0	0	0	0	0	0	1	1364	813	29	2		2	BCL10	1	85733496	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	741816	85733496	163517125	30	27877											
HFM1	164045	broad.mit.edu	37	chr1	91782033	91782033	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgcatttgacaatgttataCctgtggaaaattaatcaaac	15	14	6	6	0	1	1	1	1	0	0	1	2	1	2	1	1	3	2	1	1	7	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:91782033C>A	uc001doa.3	-	26	2913	c.2813G>T	c.(2812-2814)GGT>GTT	p.G938V	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.G617V|HFM1_uc001dob.3_Missense_Mutation_p.C126F|HFM1_uc010osv.1_Missense_Mutation_p.G622V	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	938	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CAATGTTATACCTGTGGAAAA	0.219													9	48					1.12685e-05	2.25627e-05	1	0	A	91782033	A	A	91782033	3	1	154	1	0	0	0	0	1	0	0	0	7122	521	18	4	1550	4	HFM1	1	91782033	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6048537	91782033	157468588	31	27878											
GCLM	2730	broad.mit.edu	37	chr1	94354598	94354598	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agccttttgatttgataattCctctacttttcacaatgacc	10	17	4	10	0	2	3	1	3	1	0	3	3	3	3	3	0	2	0	3	0	3	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:94354598C>T	uc001dqg.1	-	7	1066	c.773G>A	c.(772-774)GGA>GAA	p.G258E		NM_002061	NP_002052	P48507	GSH0_HUMAN	glutamate-cysteine ligase regulatory protein	258					glutamate metabolic process|glutathione biosynthetic process|regulation of blood vessel size|response to drug|response to oxidative stress|xenobiotic metabolic process	cytosol|soluble fraction	glutamate-cysteine ligase catalytic subunit binding			ovary(1)	1		all_lung(203;0.000815)|Lung NSC(277;0.00363)		all cancers(265;0.00566)|GBM - Glioblastoma multiforme(16;0.0203)|Epithelial(280;0.131)	L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	TTTGATAATTCCTCTACTTTT	0.413													5	65					0	0	0	0	T	94354598	T	T	94354598	3	4	154	1	0	0	0	0	1	0	0	0	6331	855	30	2	55	2	GCLM	1	94354598	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2572565	94354598	154896023	32	27879											
ARHGAP29	9411	broad.mit.edu	37	chr1	94650455	94650455	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaaagctctattttcaatCtctgaggcacatattttgag	12	14	6	9	0	3	2	1	2	2	0	4	2	3	2	0	1	1	2	0	1	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:94650455C>T	uc001dqj.3	-	18	2451	c.2082G>A	c.(2080-2082)GAG>GAA	p.E694E	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Silent_p.E260E	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	694	Rho-GAP.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TATTTTCAATCTCTGAGGCAC	0.323													6	44					0	0	0	0	T	94650455	T	T	94650455	2	4	154	1	0	0	0	0	0	0	0	1	878	912	32	2		2	ARHGAP29	1	94650455	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	295857	94650455	154600166	33	27880											
DBT	1629	broad.mit.edu	37	chr1	100681578	100681578	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtctttgcctgtgaataccgGaggttttgatactagtatag	9	15	11	6	1	1	2	0	2	1	0	1	3	1	3	2	2	3	2	2	2	6	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:100681578G>C	uc001dta.2	-	6	766	c.733C>G	c.(733-735)CCG>GCG	p.P245A	DBT_uc010oug.1_Missense_Mutation_p.P64A	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	245					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		GTGAATACCGGAGGTTTTGAT	0.388													18	101					0	0	0	0	C	100681578	C	C	100681578	3	2	154	1	0	0	0	0	1	0	0	0	4275	1174	41	2	739	2	DBT	1	100681578	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	6031123	100681578	148569043	34	27881											
SLC30A7	148867	broad.mit.edu	37	chr1	101361893	101361893	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttcggcaagatctcgggctgGtttaggtgcggggtgctgtg	4	12	18	7	3	1	1	0	0	1	1	3	1	1	1	0	6	2	4	0	6	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:101361893G>T	uc001dtn.2	+	1	262	c.75G>T	c.(73-75)TGG>TGT	p.W25C	EXTL2_uc001dtk.1_5'Flank|EXTL2_uc001dtl.1_5'Flank|EXTL2_uc010ouk.1_5'Flank|EXTL2_uc001dtm.1_5'Flank|SLC30A7_uc001dto.2_Missense_Mutation_p.W25C	NM_001144884	NP_001138356	Q8NEW0	ZNT7_HUMAN	zinc transporter like 2	25	Cytoplasmic (Potential).				zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)		TCTCGGGCTGGTTTAGGTGCG	0.587													10	63					0.000673444	0.00128547	1	0	T	101361893	T	T	101361893	3	4	154	1	0	0	0	0	1	0	0	0	14624	1270	44	4	77	4	SLC30A7	1	101361893	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	680315	101361893	147888728	35	27882											
DDX20	11218	broad.mit.edu	37	chr1	112304903	112304903	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaatcagaatcagcgtcttGatgctatggctaaactgaag	13	11	10	7	1	3	4	2	3	1	1	3	4	3	4	0	1	3	2	0	1	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:112304903G>C	uc001ebs.2	+	8	1405	c.1048G>C	c.(1048-1050)GAT>CAT	p.D350H	DDX20_uc010owf.1_Missense_Mutation_p.D112H|DDX20_uc001ebt.2_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	350	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCAGCGTCTTGATGCTATGGC	0.353													4	90					0	0	0	0	C	112304903	C	C	112304903	3	2	154	1	0	0	0	0	1	0	0	0	4365	1290	45	2	1078	2	DDX20	1	112304903	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	10943010	112304903	136945718	36	27883											
RSBN1	54665	broad.mit.edu	37	chr1	114354824	114354824	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaggtttctccttcccctCtttgtccggctcctcctgcg	2	15	8	16	2	2	1	0	1	2	0	7	1	6	1	6	2	1	2	6	2	0	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:114354824C>G	uc001edq.2	-	1	247	c.211G>C	c.(211-213)GAG>CAG	p.E71Q	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	71						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCCTTCCCCTCTTTGTCCGGC	0.652													4	108					0	0	0	0	G	114354824	G	G	114354824	3	3	154	1	0	0	0	0	1	0	0	0	13761	922	32	2	2225	2	RSBN1	1	114354824	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2049921	114354824	134895797	37	27884											
NRAS	4893	broad.mit.edu	37	chr1	115256551	115256551	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccagctgtatccagtatgtCcaacaaacaggtttcaccat	12	11	6	12	0	1	0	1	0	0	0	4	0	4	0	4	1	3	4	4	1	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:115256551C>A	uc009wgu.2	-	3	414	c.160G>T	c.(160-162)GAC>TAC	p.D54Y		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	54					activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity			haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCCAGTATGTCCAACAAACAG	0.458		50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			32	97					4.34311e-12	9.94164e-12	1	0	A	115256551	A	A	115256551	3	1	154	1	0	0	0	0	1	0	0	0	10694	855	30	2	421	2	NRAS	1	115256551	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	901727	115256551	133994070	38	27885											
TTF2	8458	broad.mit.edu	37	chr1	117624455	117624455	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttttattttctagcagatGatatgggcttaggaaaaacc	12	14	9	6	0	1	2	0	1	1	1	1	3	1	3	1	2	2	3	1	2	6	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:117624455G>A	uc001egy.2	+	10	1809	c.1789G>A	c.(1789-1791)GAT>AAT	p.D597N	TTF2_uc001egx.1_Missense_Mutation_p.D597N	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	597	Helicase ATP-binding.|ATP (Potential).				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TCTAGCAGATGATATGGGCTT	0.403													8	43					0	0	0	0	A	117624455	A	A	117624455	3	1	154	1	0	0	0	0	1	0	0	0	16787	1290	45	2	1827	2	TTF2	1	117624455	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2367904	117624455	131626166	39	27886											
TTF2	8458	broad.mit.edu	37	chr1	117637947	117637947	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagatttcatctctgttggCagaattggaggcaattcaaa	12	12	9	8	0	3	2	2	0	1	2	4	3	3	3	1	3	0	3	1	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:117637947C>G	uc001egy.2	+	19	3013	c.2993C>G	c.(2992-2994)GCA>GGA	p.A998G		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	998	Helicase C-terminal.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TCTCTGTTGGCAGAATTGGAG	0.279													3	58					0	0	0	0	G	117637947	G	G	117637947	3	3	154	1	0	0	0	0	1	0	0	0	16787	710	25	4	3067	4	TTF2	1	117637947	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	13492	117637947	131612674	40	27887											
GJA5	2702	broad.mit.edu	37	chr1	147230503	147230503	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggccatattattgctgaaggGattgaagaattttcccccag	11	12	10	8	0	0	3	0	2	0	1	1	4	1	4	3	2	1	1	3	2	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:147230503G>A	uc001eps.1	-	2	985	c.844C>T	c.(844-846)CCC>TCC	p.P282S	GJA5_uc001ept.1_Missense_Mutation_p.P282S	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	282	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			TTGCTGAAGGGATTGAAGAAT	0.542													5	144					0	0	0	0	A	147230503	A	A	147230503	3	1	154	1	0	0	0	0	1	0	0	0	6441	1174	41	2	236	2	GJA5	1	147230503	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	29592556	147230503	102020118	41	27888											
APH1A	51107	broad.mit.edu	37	chr1	150239858	150239858	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagaagacaccactgatgaTaccgaaggagagaccagaaa	19	3	11	8	1	0	6	0	2	0	4	0	10	0	7	3	1	1	0	3	1	4	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:150239858T>A	uc001ety.1	-	4	701	c.379A>T	c.(379-381)ATC>TTC	p.I127F	APH1A_uc010pbx.1_Missense_Mutation_p.I57F|APH1A_uc001etz.1_Missense_Mutation_p.I127F|APH1A_uc001eua.1_Missense_Mutation_p.I127F|APH1A_uc010pby.1_Missense_Mutation_p.I70F|APH1A_uc001eub.1_Missense_Mutation_p.I11F|APH1A_uc010pbz.1_Missense_Mutation_p.I11F	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	127	Helical; Name=4; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCACTGATGATACCGAAGGAG	0.498													25	37					0	0	0	0	A	150239858	A	A	150239858	3	1	154	1	0	0	0	0	1	0	0	0	771	1406	49	5	445	5	APH1A	1	150239858	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	3009355	150239858	99010763	42	27889											
TCHHL1	126637	broad.mit.edu	37	chr1	152059098	152059098	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgttctgccataatcctCaggttcacccaaattctttg	10	14	6	11	0	4	1	2	0	2	1	5	1	5	1	3	1	1	2	3	1	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:152059098C>G	uc001ezo.1	-	3	1125	c.1060G>C	c.(1060-1062)GAG>CAG	p.E354Q		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	354							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CCATAATCCTCAGGTTCACCC	0.418													33	265					0	0	0	0	G	152059098	G	G	152059098	3	3	154	1	0	0	0	0	1	0	0	0	15767	835	29	2	1658	2	TCHHL1	1	152059098	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1819240	152059098	97191523	43	27890											
FLG	2312	broad.mit.edu	37	chr1	152278665	152278665	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctcagagtcttctgaatgTccctcactgtcactgtcctg	6	14	7	14	0	5	2	3	1	3	1	8	2	7	2	2	0	0	0	2	0	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:152278665T>C	uc001ezu.1	-	3	8733	c.8697A>G	c.(8695-8697)GGA>GGG	p.G2899G		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2899	Ser-rich.|Filaggrin 17.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTCTGAATGTCCCTCACTGT	0.567									Ichthyosis				12	484					0	0	0	0	C	152278665	C	C	152278665	2	2	154	1	0	0	0	0	0	0	0	1	5954	1654	58	5		5	FLG	1	152278665	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	219567	152278665	96971956	44	27891											
FLG	2312	broad.mit.edu	37	chr1	152284282	152284282	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtgtctttctcctggacttGatcttgcctgttcatgggat	4	17	10	10	1	4	1	1	1	3	0	5	3	4	3	2	2	1	1	2	2	0	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:152284282G>C	uc001ezu.1	-	3	3116	c.3080C>G	c.(3079-3081)TCA>TGA	p.S1027*	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1027	Filaggrin 6.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGGACTTGATCTTGCCTG	0.572									Ichthyosis				202	432					0	0	0	0	C	152284282	C	C	152284282	4	2	154	1	0	0	0	0	0	1	0	0	5954	1294	45	2	9109	2	FLG	1	152284282	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5617	152284282	96966339	45	27892											
LCE4A	199834	broad.mit.edu	37	chr1	152681605	152681605	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccctcccaagtgtcctatCcccaagtatcccccaaaatg	10	8	4	19	0	0	0	0	0	0	0	4	0	4	0	8	0	0	1	8	0	6	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:152681605C>A	uc001fak.2	+	1	83	c.54C>A	c.(52-54)ATC>ATA	p.I18I		NM_178356	NP_848133	Q5TA78	LCE4A_HUMAN	late cornified envelope 4A	18	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.116)			AGTGTCCTATCCCCAAGTATC	0.517													24	153					5.45024e-15	1.29655e-14	1	0	A	152681605	A	A	152681605	2	1	154	1	0	0	0	0	0	0	0	1	8714	845	30	2		2	LCE4A	1	152681605	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	397323	152681605	96569016	46	27893											
SPRR1B	6699	broad.mit.edu	37	chr1	153004978	153004978	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagccctgccaccccaaaGtgcccgagccctgccagccc	7	4	9	21	1	0	1	0	1	0	0	0	2	0	1	8	0	6	0	8	0	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:153004978G>A	uc001fba.2	+	2	221	c.157G>A	c.(157-159)GTG>ATG	p.V53M	SPRR1B_uc009wnx.1_Splice_Site	NM_003125	NP_003116	P22528	SPR1B_HUMAN	small proline-rich protein 1B	53	6 X 8 AA approximate tandem repeats.|3.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCACCCCAAAGTGCCCGAGCC	0.632													19	177					0	0	0	0	A	153004978	A	A	153004978	3	1	154	1	0	0	0	0	1	0	0	0	15162	1029	36	4	159	4	SPRR1B	1	153004978	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	323373	153004978	96245643	47	27894											
CRTC2	200186	broad.mit.edu	37	chr1	153926054	153926054	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgaaacaactgccccttctCtgcagggaaattgccccagg	10	8	9	14	1	1	0	0	0	1	0	3	2	1	1	4	2	5	1	4	2	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:153926054C>G	uc010ped.1	-	5	533	c.463G>C	c.(463-465)GAG>CAG	p.E155Q	CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_5'UTR	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	155					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGCCCCTTCTCTGCAGGGAAA	0.517													4	40					0	0	0	0	G	153926054	G	G	153926054	3	3	154	1	0	0	0	0	1	0	0	0	3915	922	32	2	1658	2	CRTC2	1	153926054	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	921076	153926054	95324567	48	27895											
GBA	2629	broad.mit.edu	37	chr1	155209413	155209413	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccttcctcctcaccttcttCagagaagtacgatttaagta	10	13	5	13	1	3	1	2	0	1	1	5	3	5	1	4	0	1	2	4	0	4	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:155209413C>T	uc001fjh.2	-	4	598	c.448G>A	c.(448-450)GAA>AAA	p.E150K	RAG1AP1_uc010pey.1_Intron|GBA_uc010pfw.1_Intron|GBA_uc010pfx.1_Intron|GBA_uc001fji.2_Missense_Mutation_p.E150K|GBA_uc001fjj.2_Missense_Mutation_p.E150K|GBA_uc001fjk.2_Missense_Mutation_p.E150K|GBA_uc001fjl.2_Missense_Mutation_p.E150K|GBA_uc010pfy.1_Missense_Mutation_p.E63K|GBA_uc009wqk.1_Missense_Mutation_p.E63K	NM_000157	NP_000148	P04062	GLCM_HUMAN	glucocerebrosidase precursor	150					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			ovary(1)|skin(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	TCACCTTCTTCAGAGAAGTAC	0.363									Gaucher_disease_type_I				8	44					0	0	0	0	T	155209413	T	T	155209413	3	4	154	1	0	0	0	0	1	0	0	0	6301	835	29	2	1194	2	GBA	1	155209413	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1283359	155209413	94041208	49	27896											
ARHGEF2	9181	broad.mit.edu	37	chr1	155924708	155924708	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttactcttaattcgccgcaGgtaagcctcatcctctgtct	7	14	6	14	2	4	0	1	0	3	0	6	0	5	0	3	1	2	2	3	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:155924708G>A	uc001fmt.2	-	14	1886	c.1768C>T	c.(1768-1770)CTG>TTG	p.L590L	ARHGEF2_uc001fmr.2_Silent_p.L562L|ARHGEF2_uc001fms.2_Silent_p.L589L|ARHGEF2_uc001fmu.2_Silent_p.L634L	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2	590	Potential.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					ATTCGCCGCAGGTAAGCCTCA	0.313													35	80					0	0	0	0	A	155924708	A	A	155924708	2	1	154	1	0	0	0	0	0	0	0	1	903	991	35	4		4	ARHGEF2	1	155924708	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	715295	155924708	93325913	50	27897											
FCRL4	83417	broad.mit.edu	37	chr1	157545497	157545497	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgaaactcaccttatcctCtagaagtgtcctggaggtat	12	12	8	9	0	2	2	1	1	1	1	4	3	4	3	3	2	1	1	3	2	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:157545497C>A	uc001fqw.2	-	11	1589	c.1453G>T	c.(1453-1455)GAG>TAG	p.E485*	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	485	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				ACCTTATCCTCTAGAAGTGTC	0.458													37	86					7.53189e-24	1.8597e-23	1	0	A	157545497	A	A	157545497	4	1	154	1	0	0	0	0	0	1	0	0	5829	922	32	2	102	2	FCRL4	1	157545497	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1620789	157545497	91705124	51	27898											
FCRL4	83417	broad.mit.edu	37	chr1	157556230	157556230	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgggtctccaggagcaccCcagacacagggatccctatg	9	6	12	14	0	1	1	0	0	1	1	3	3	2	3	4	3	1	2	4	3	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:157556230C>G	uc001fqw.2	-	6	999	c.863G>C	c.(862-864)GGG>GCG	p.G288A	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	288	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				CAGGAGCACCCCAGACACAGG	0.602													25	60					0	0	0	0	G	157556230	G	G	157556230	3	3	154	1	0	0	0	0	1	0	0	0	5829	623	22	4	712	4	FCRL4	1	157556230	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	10733	157556230	91694391	52	27899											
CD1D	912	broad.mit.edu	37	chr1	158153926	158153926	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattctctcacagttcctatCagggcgtcctgtgactcgcc	6	13	8	14	2	3	1	2	1	1	0	7	1	5	1	3	1	0	1	3	1	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:158153926C>T	uc001frr.2	+	7	1493	c.994C>T	c.(994-996)CAG>TAG	p.Q332*	CD1D_uc009wss.2_Nonsense_Mutation_p.Q239*	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	332	Cytoplasmic (Potential).|Internalization signal.				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					CAGTTCCTATCAGGGCGTCCT	0.512													8	136					0	0	0	0	T	158153926	T	T	158153926	4	4	154	1	0	0	0	0	0	1	0	0	2992	827	29	2	1016	2	CD1D	1	158153926	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	597696	158153926	91096695	53	27900											
OR6N2	81442	broad.mit.edu	37	chr1	158746552	158746552	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgatttccttgttacgaaGactgtagataattggattga	13	15	9	4	1	0	4	0	2	0	2	1	6	1	5	1	1	1	2	1	1	5	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:158746552G>T	uc010pir.1	-	1	874	c.874C>A	c.(874-876)CTT>ATT	p.L292I		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TTGTTACGAAGACTGTAGATA	0.418													27	86					1.55811e-20	3.80968e-20	1	0	T	158746552	T	T	158746552	3	4	154	1	0	0	0	0	1	0	0	0	11261	942	33	2	82	2	OR6N2	1	158746552	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	592626	158746552	90504069	54	27901											
OR6N2	81442	broad.mit.edu	37	chr1	158746962	158746962	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgacctcagaaatgggaCacaggaagccacaagtccaa	16	4	11	10	0	1	2	1	1	0	1	2	5	2	5	3	3	1	0	3	3	4	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:158746962C>A	uc010pir.1	-	1	464	c.464G>T	c.(463-465)TGT>TTT	p.C155F		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					AGAAATGGGACACAGGAAGCC	0.498													18	69					8.34094e-07	1.73121e-06	1	0	A	158746962	A	A	158746962	3	1	154	1	0	0	0	0	1	0	0	0	11261	478	17	4	492	4	OR6N2	1	158746962	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	410	158746962	90503659	55	27902											
MNDA	4332	broad.mit.edu	37	chr1	158812150	158812150	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaaactaatagaacttgcCaaagatatgccatcacttaa	18	9	5	9	0	1	2	1	0	0	2	1	3	1	2	2	0	4	0	2	0	7	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:158812150C>A	uc001fsz.1	+	2	407	c.207C>A	c.(205-207)GCC>GCA	p.A69A		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	69	DAPIN.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TAGAACTTGCCAAAGATATGC	0.358													31	74					5.60225e-13	1.30447e-12	1	0	A	158812150	A	A	158812150	2	1	154	1	0	0	0	0	0	0	0	1	9729	581	21	4		4	MNDA	1	158812150	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	65188	158812150	90438471	56	27903											
OR10J1	26476	broad.mit.edu	37	chr1	159410397	159410397	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagagaacatgaccagctGatctcggtgacctacactgt	12	8	9	12	1	1	4	0	3	1	1	2	5	1	4	3	1	3	1	3	1	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:159410397G>C	uc010piv.1	+	1	849	c.849G>C	c.(847-849)CTG>CTC	p.L283L	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	283	Helical; Name=7; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					ATGACCAGCTGATCTCGGTGA	0.522													22	88					0	0	0	0	C	159410397	C	C	159410397	2	2	154	1	0	0	0	0	0	0	0	1	10964	1277	45	2		2	OR10J1	1	159410397	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	598247	159410397	89840224	57	27904											
ATP1A2	477	broad.mit.edu	37	chr1	160098579	160098579	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacccagaaccgcatgacCgtcgcccacatgtggttcga	9	7	9	16	4	1	2	1	1	0	1	3	3	1	2	4	1	1	2	4	1	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:160098579C>A	uc001fvc.2	+	9	1287	c.1155C>A	c.(1153-1155)ACC>ACA	p.T385T	ATP1A2_uc001fvb.2_Silent_p.T385T|ATP1A2_uc010piz.1_Silent_p.T230T|ATP1A2_uc001fvd.2_Silent_p.T121T|ATP1A2_uc009wtg.1_Silent_p.T73T	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	385	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			ACCGCATGACCGTCGCCCACA	0.592													32	84					2.68265e-12	6.19724e-12	1	0	A	160098579	A	A	160098579	2	1	154	1	0	0	0	0	0	0	0	1	1131	639	23	3		3	ATP1A2	1	160098579	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	688182	160098579	89152042	58	27905											
NUF2	83540	broad.mit.edu	37	chr1	163317670	163317670	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaaaaacttgccacagcaCaattcaaaataaataagaag	22	6	6	7	0	1	1	1	0	0	1	1	2	1	2	1	1	3	1	1	1	9	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:163317670C>A	uc001gcq.1	+	12	1366	c.1066C>A	c.(1066-1068)CAA>AAA	p.Q356K	NUF2_uc001gcr.1_Missense_Mutation_p.Q356K|NUF2_uc009wvc.1_Missense_Mutation_p.Q309K	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	356	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					TGCCACAGCACAATTCAAAAT	0.323													5	19					0.000602214	0.00115452	1	0	A	163317670	A	A	163317670	3	1	154	1	0	0	0	0	1	0	0	0	10801	479	17	4	1108	4	NUF2	1	163317670	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3219091	163317670	85932951	59	27906											
DUSP27	92235	broad.mit.edu	37	chr1	167095719	167095719	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccacgacatctgggtcCtgaagcagcagctggagctg	9	6	14	12	1	1	1	0	1	1	0	2	3	2	2	2	2	5	5	2	2	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:167095719C>T	uc001geb.1	+	5	1351	c.1351C>T	c.(1351-1353)CTG>TTG	p.L451L		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	451					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CATCTGGGTCCTGAAGCAGCA	0.662													5	8					0	0	0	0	T	167095719	T	T	167095719	2	4	154	1	0	0	0	0	0	0	0	1	4846	680	24	4		4	DUSP27	1	167095719	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3778049	167095719	82154902	60	27907											
ATP1B1	481	broad.mit.edu	37	chr1	169094256	169094256	+	RNA	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcagcccagagggatgacAtgatttttgaagattgtggc	11	12	12	6	0	1	5	1	3	0	2	1	6	1	6	1	2	1	0	1	2	1	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:169094256A>G	uc001gfs.1	+	3		c.482A>G			uc010plp.1_5'Flank			P05026	AT1B1_HUMAN	Synthetic construct DNA, clone: pF1KB8186, Homo sapiens ATP1B1 gene for ATPase, Na+/K+ transporting, beta 1 polypeptide, without stop codon, in Flexi system.						ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	all_hematologic(923;0.208)					GAGGGATGACATGATTTTTGA	0.373													8	134					0	0	0	0	G	169094256	G	G	169094256	1	3	154	0	1	0	0	0	0	0	0	0	1134	217	8	5		5	ATP1B1	1	169094256	RNA	SNP	A	TCGA-CR-7388-01A-11D-2012-08	1998537	169094256	80156365	61	27908											
C1orf129	80133	broad.mit.edu	37	chr1	170961323	170961323	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcactctgatacagatgtgGaaggcggcatgttctcaggc	10	9	13	9	1	2	2	1	1	2	1	3	3	2	3	0	4	2	3	0	4	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:170961323G>A	uc001ghg.2	+	12	1177	c.1047G>A	c.(1045-1047)TGG>TGA	p.W349*	C1orf129_uc009wvy.2_Nonsense_Mutation_p.W156*|C1orf129_uc010plz.1_Nonsense_Mutation_p.W349*	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	349							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TACAGATGTGGAAGGCGGCAT	0.478													5	41					0	0	0	0	A	170961323	A	A	170961323	4	1	154	1	0	0	0	0	0	1	0	0	2005	1183	41	2	1089	2	C1orf129	1	170961323	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1867067	170961323	78289298	62	27909											
FMO4	2329	broad.mit.edu	37	chr1	171293343	171293343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcagtgggatgttgtcacaGagacagagggcaagcaaaat	14	7	14	6	0	2	2	2	0	0	2	2	4	2	3	0	2	1	3	0	2	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:171293343G>A	uc001gho.2	+	5	605	c.388G>A	c.(388-390)GAG>AAG	p.E130K		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	130					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGTTGTCACAGAGACAGAGGG	0.458													33	401					0	0	0	0	A	171293343	A	A	171293343	3	1	154	1	0	0	0	0	1	0	0	0	5989	943	33	2	398	2	FMO4	1	171293343	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	332020	171293343	77957278	63	27910											
RC3H1	149041	broad.mit.edu	37	chr1	173934113	173934113	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgttgatacaattccatttgGcagagcaggaggttttctgc	9	14	11	7	0	1	2	0	1	1	1	2	3	2	3	1	3	3	4	1	3	2	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:173934113G>C	uc001gju.3	-	9	1567	c.1480C>G	c.(1480-1482)CCA>GCA	p.P494A	RC3H1_uc010pms.1_Missense_Mutation_p.P494A|RC3H1_uc001gjv.2_Missense_Mutation_p.P494A|RC3H1_uc010pmt.1_Missense_Mutation_p.P494A	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	494					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						ATTCCATTTGGCAGAGCAGGA	0.478													34	87					0	0	0	0	C	173934113	C	C	173934113	3	2	154	1	0	0	0	0	1	0	0	0	13231	1203	42	4	1965	4	RC3H1	1	173934113	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2640770	173934113	75316508	64	27911											
PAPPA2	60676	broad.mit.edu	37	chr1	176640191	176640191	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctactttgccagctcagtgCgggaagaccttgcaggtgct	7	11	12	11	1	2	1	1	0	1	1	2	2	2	2	2	2	6	3	2	2	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:176640191C>G	uc001gkz.2	+	4	3241	c.2077C>G	c.(2077-2079)CGG>GGG	p.R693G	PAPPA2_uc001gky.1_Missense_Mutation_p.R693G|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	693	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CAGCTCAGTGCGGGAAGACCT	0.507													63	148					0	0	0	0	G	176640191	G	G	176640191	3	3	154	1	0	0	0	0	1	0	0	0	11487	759	27	3	2087	3	PAPPA2	1	176640191	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2706078	176640191	72610430	65	27912											
ABL2	27	broad.mit.edu	37	chr1	179084079	179084079	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccattcgatatcctttttCtagtaggtcatagacctgag	9	16	7	9	1	2	2	1	1	1	1	5	3	4	2	3	1	0	1	3	1	4	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:179084079C>T	uc001gmj.3	-	9	1782	c.1495G>A	c.(1495-1497)GAA>AAA	p.E499K	ABL2_uc010pnf.1_Missense_Mutation_p.E499K|ABL2_uc010png.1_Missense_Mutation_p.E478K|ABL2_uc010pnh.1_Missense_Mutation_p.E478K|ABL2_uc009wxe.2_Missense_Mutation_p.E478K|ABL2_uc001gmg.3_Missense_Mutation_p.E484K|ABL2_uc001gmi.3_Missense_Mutation_p.E484K|ABL2_uc001gmh.3_Missense_Mutation_p.E463K|ABL2_uc010pne.1_Missense_Mutation_p.E463K	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	499	Protein kinase.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TATCCTTTTTCTAGTAGGTCA	0.408			T	ETV6	AML								7	77					0	0	0	0	T	179084079	T	T	179084079	3	4	154	1	0	0	0	0	1	0	0	0	93	922	32	2	2114	2	ABL2	1	179084079	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2443888	179084079	70166542	66	27913											
C1orf125	126859	broad.mit.edu	37	chr1	179398721	179398721	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaaaaggctggaataaataCactaagcatttcatcatact	18	10	6	7	0	2	0	2	0	0	0	2	2	2	1	0	2	3	2	0	2	8	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:179398721C>T	uc001gmo.2	+	13	1426	c.1299C>T	c.(1297-1299)TAC>TAT	p.Y433Y	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Silent_p.Y221Y|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Silent_p.Y433Y	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	433											0						GGAATAAATACACTAAGCATT	0.333													6	39					0	0	0	0	T	179398721	T	T	179398721	2	4	154	1	0	0	0	0	0	0	0	1	2002	489	17	4		4	C1orf125	1	179398721	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	314642	179398721	69851900	67	27914											
NMNAT2	23057	broad.mit.edu	37	chr1	183230439	183230439	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaccaacaatcacctccatCtaaagaaacagagagagggc	17	5	7	12	0	3	3	2	0	1	3	4	4	4	3	3	1	2	0	3	1	5	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:183230439C>G	uc001gqc.1	-	9	987	c.652_splice	c.e9-1	p.M218_splice	NMNAT2_uc009wye.1_Splice_Site|NMNAT2_uc001gqb.1_Splice_Site_p.M213_splice	NM_015039	NP_055854	Q9BZQ4	NMNA2_HUMAN	nicotinamide mononucleotide adenylyltransferase						water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			skin(1)	1						TCACCTCCATCTAAAGAAACA	0.498													20	35					0	0	0	0	G	183230439	G	G	183230439	5	3	154	1	0	0	0	0	0	0	1	0	10553	927	32	2	284	2	NMNAT2	1	183230439	Splice_Site	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3831718	183230439	66020182	68	27915											
HMCN1	83872	broad.mit.edu	37	chr1	185833652	185833652	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagctataaaaattgccttGgaaatttctcttcctggttc	10	15	8	8	0	1	0	0	0	1	0	4	2	2	2	2	3	2	2	2	3	5	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:185833652G>A	uc001grq.1	+	3	619	c.390G>A	c.(388-390)TTG>TTA	p.L130L		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	130	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AAATTGCCTTGGAAATTTCTC	0.408													6	43					0	0	0	0	A	185833652	A	A	185833652	2	1	154	1	0	0	0	0	0	0	0	1	7259	1339	47	4		4	HMCN1	1	185833652	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2603213	185833652	63416969	69	27916											
HMCN1	83872	broad.mit.edu	37	chr1	185972962	185972962	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccctttcctgatattcattgGttcaaagatggcaagtgagt	10	14	9	8	0	2	3	2	2	0	1	3	3	3	3	2	2	0	2	2	2	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:185972962G>T	uc001grq.1	+	29	4690	c.4461G>T	c.(4459-4461)TGG>TGT	p.W1487C		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1487	Ig-like C2-type 12.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATATTCATTGGTTCAAAGATG	0.403													6	56					0.00307968	0.00575353	1	0	T	185972962	T	T	185972962	3	4	154	1	0	0	0	0	1	0	0	0	7259	1270	44	4	4575	4	HMCN1	1	185972962	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	139310	185972962	63277659	70	27917											
HMCN1	83872	broad.mit.edu	37	chr1	186064470	186064470	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcattactgatggaaccccaGctcccagtatggcctggctt	8	10	10	13	0	0	1	0	1	0	0	1	2	1	2	4	3	3	4	4	3	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:186064470G>T	uc001grq.1	+	68	10619	c.10390G>T	c.(10390-10392)GCT>TCT	p.A3464S		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3464	Ig-like C2-type 33.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGGAACCCCAGCTCCCAGTAT	0.517													8	39					0.000157383	0.000305386	1	0	T	186064470	T	T	186064470	3	4	154	1	0	0	0	0	1	0	0	0	7259	971	34	4	10660	4	HMCN1	1	186064470	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	91508	186064470	63186151	71	27918											
FAM5C	339479	broad.mit.edu	37	chr1	190067524	190067524	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggttcatagtaaatgctcTcattaccattgggaccattg	11	13	9	8	0	2	0	2	0	1	0	3	2	2	1	2	2	2	3	2	2	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:190067524T>A	uc001gse.1	-	8	2157	c.1925A>T	c.(1924-1926)GAG>GTG	p.E642V	FAM5C_uc010pot.1_Missense_Mutation_p.E540V	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	642						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GTAAATGCTCTCATTACCATT	0.413													34	177					0	0	0	0	A	190067524	A	A	190067524	3	1	154	1	0	0	0	0	1	0	0	0	5626	1551	54	5	379	5	FAM5C	1	190067524	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	4003054	190067524	59183097	72	27919											
RGS1	5996	broad.mit.edu	37	chr1	192548282	192548282	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagatcaatattgacttcCgcactcgagaatctacagcc	12	12	6	11	2	2	3	1	1	1	2	4	4	3	3	2	0	2	1	2	0	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:192548282C>G	uc001gsi.1	+	5	526	c.460C>G	c.(460-462)CGC>GGC	p.R154G		NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	154	RGS.				immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				TATTGACTTCCGCACTCGAGA	0.333													13	71					0	0	0	0	G	192548282	G	G	192548282	3	3	154	1	0	0	0	0	1	0	0	0	13357	652	23	3	478	3	RGS1	1	192548282	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2480758	192548282	56702339	73	27920											
ZBTB41	360023	broad.mit.edu	37	chr1	197128811	197128811	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggaacacatacttcagcaGatacattctgtaacatcgtc	13	11	6	11	1	2	1	1	0	1	1	4	2	2	2	0	1	5	2	0	1	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:197128811G>C	uc001gtx.1	-	10	2477	c.2408C>G	c.(2407-2409)TCT>TGT	p.S803C	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	803					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TACTTCAGCAGATACATTCTG	0.428													12	104					0	0	0	0	C	197128811	C	C	197128811	3	2	154	1	0	0	0	0	1	0	0	0	17610	942	33	2	325	2	ZBTB41	1	197128811	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4580529	197128811	52121810	74	27921											
PTPRC	5788	broad.mit.edu	37	chr1	198682089	198682089	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcttttaacaggtccaggAgagcctcagattattttttg	10	16	8	7	0	2	2	1	0	1	2	3	3	3	2	2	2	2	0	2	2	2	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:198682089A>G	uc001gur.1	+	12	1353	c.1173A>G	c.(1171-1173)GGA>GGG	p.G391G	PTPRC_uc001gus.1_Silent_p.G343G|PTPRC_uc001gut.1_Silent_p.G230G|PTPRC_uc009wzf.1_Silent_p.G279G|PTPRC_uc010ppg.1_Silent_p.G327G	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	391	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CAGGTCCAGGAGAGCCTCAGA	0.318													26	59					0	0	0	0	G	198682089	G	G	198682089	2	3	154	1	0	0	0	0	0	0	0	1	12862	291	11	5		5	PTPRC	1	198682089	Silent	SNP	A	TCGA-CR-7388-01A-11D-2012-08	1553278	198682089	50568532	75	27922											
FAM58B	339521	broad.mit.edu	37	chr1	200182931	200182931	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgattgccatgtcttcCatttacttggccggcaaagt	8	14	8	11	1	1	1	0	1	1	0	2	1	2	1	4	2	3	1	4	2	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:200182931C>A	uc009wzi.1	+	1	276	c.240C>A	c.(238-240)TCC>TCA	p.S80S		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	80					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					CCATGTCTTCCATTTACTTGG	0.527													53	155					1.83081e-24	4.52681e-24	1	0	A	200182931	A	A	200182931	2	1	154	1	0	0	0	0	0	0	0	1	5623	581	21	4		4	FAM58B	1	200182931	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1500842	200182931	49067690	76	27923											
C4BPB	725	broad.mit.edu	37	chr1	207265029	207265029	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgctggtgaatggagagttCagttcttcagggcctgtgaa	8	12	15	6	0	3	3	2	2	1	1	3	4	3	3	1	3	1	3	1	3	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:207265029C>G	uc001hfj.2	+	4	403	c.273C>G	c.(271-273)TTC>TTG	p.F91L	C4BPB_uc001hfi.2_Missense_Mutation_p.F90L|C4BPB_uc001hfk.2_Missense_Mutation_p.F90L|C4BPB_uc001hfl.2_Missense_Mutation_p.F91L|C4BPB_uc009xcd.2_Missense_Mutation_p.F81L|C4BPB_uc001hfm.2_Missense_Mutation_p.F91L|C4BPB_uc010pse.1_Missense_Mutation_p.F81L	NM_001017365	NP_001017365	P20851	C4BPB_HUMAN	complement component 4 binding protein, beta	91	Sushi 2.				blood coagulation|complement activation, classical pathway|innate immune response	extracellular region				ovary(1)	1						ATGGAGAGTTCAGTTCTTCAG	0.483													7	123					0	0	0	0	G	207265029	G	G	207265029	3	3	154	1	0	0	0	0	1	0	0	0	2260	825	29	2	283	2	C4BPB	1	207265029	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	7082098	207265029	41985592	77	27924											
C4BPB	725	broad.mit.edu	37	chr1	207265065	207265065	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaatgtaagtgacaaaatCacgtttatgtgcaatgacca	15	11	9	6	1	1	3	1	3	0	0	1	3	1	3	1	0	1	3	1	0	6	3	rs139041322		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:207265065C>G	uc001hfj.2	+	4	439	c.309C>G	c.(307-309)ATC>ATG	p.I103M	C4BPB_uc001hfi.2_Missense_Mutation_p.I102M|C4BPB_uc001hfk.2_Missense_Mutation_p.I102M|C4BPB_uc001hfl.2_Missense_Mutation_p.I103M|C4BPB_uc009xcd.2_Missense_Mutation_p.I93M|C4BPB_uc001hfm.2_Missense_Mutation_p.I103M|C4BPB_uc010pse.1_Missense_Mutation_p.I93M	NM_001017365	NP_001017365	P20851	C4BPB_HUMAN	complement component 4 binding protein, beta	103	Sushi 2.				blood coagulation|complement activation, classical pathway|innate immune response	extracellular region				ovary(1)	1						GTGACAAAATCACGTTTATGT	0.483													6	101					0	0	0	0	G	207265065	G	G	207265065	3	3	154	1	0	0	0	0	1	0	0	0	2260	816	29	2	319	2	C4BPB	1	207265065	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	36	207265065	41985556	78	27925											
CR1	1378	broad.mit.edu	37	chr1	207753627	207753627	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcatggtgagcatacccCaagccatcaggacaactttt	11	9	8	13	0	1	1	1	1	0	0	1	2	1	2	4	2	5	2	4	2	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:207753627C>T	uc001hfy.2	+	22	3769	c.3629C>T	c.(3628-3630)CCA>CTA	p.P1210L	CR1_uc009xcl.1_Missense_Mutation_p.P760L|CR1_uc001hfx.2_Missense_Mutation_p.P1660L	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1210	Extracellular (Potential).|Sushi 19.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						GAGCATACCCCAAGCCATCAG	0.522													10	177					0	0	0	0	T	207753627	T	T	207753627	3	4	154	1	0	0	0	0	1	0	0	0	3855	594	21	4	5097	4	CR1	1	207753627	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	488562	207753627	41496994	79	27926											
INTS7	25896	broad.mit.edu	37	chr1	212151750	212151750	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatggcacatcaaaatccggGcagcgtcttgagcactgtgc	11	8	11	11	2	2	1	1	1	1	0	3	1	3	1	1	2	3	3	1	2	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:212151750G>A	uc001hiw.1	-	11	1439	c.1334C>T	c.(1333-1335)GCC>GTC	p.A445V	INTS7_uc009xdb.1_Missense_Mutation_p.A445V|INTS7_uc001hix.1_Missense_Mutation_p.A321V|INTS7_uc001hiy.1_Missense_Mutation_p.A445V|INTS7_uc010pta.1_Missense_Mutation_p.A396V	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	445					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CAAAATCCGGGCAGCGTCTTG	0.532													12	77					0	0	0	0	A	212151750	A	A	212151750	3	1	154	1	0	0	0	0	1	0	0	0	7822	1203	42	4	1594	4	INTS7	1	212151750	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4398123	212151750	37098871	80	27927											
VASH2	79805	broad.mit.edu	37	chr1	213146178	213146178	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcaagattgggctgtacGtcccccatgagcctcatagc	9	9	11	12	1	2	2	2	1	0	1	3	2	3	2	3	2	3	2	3	2	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:213146178G>T	uc001hjy.2	+	5	958	c.754G>T	c.(754-756)GTC>TTC	p.V252F	VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Missense_Mutation_p.V187F|VASH2_uc010ptn.1_Missense_Mutation_p.V148F|VASH2_uc001hjw.2_Missense_Mutation_p.V208F	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3	252					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		TGGGCTGTACGTCCCCCATGA	0.498													32	60					1.36161e-19	3.3154e-19	1	0	T	213146178	T	T	213146178	3	4	154	1	0	0	0	0	1	0	0	0	17194	1145	40	3	772	3	VASH2	1	213146178	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	994428	213146178	36104443	81	27928											
PROX1	5629	broad.mit.edu	37	chr1	214171246	214171246	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtctgcctccggccctgcCgctggcggccaccaccagcc	4	5	11	21	3	1	0	0	0	1	0	2	0	2	0	8	3	3	1	8	3	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:214171246C>A	uc001hkh.2	+	2	1640	c.1368C>A	c.(1366-1368)GCC>GCA	p.A456A	PROX1_uc001hkg.1_Silent_p.A456A	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	456				PAA -> LV (in Ref. 1; AAC50656).	aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CCGGCCCTGCCGCTGGCGGCC	0.642													33	102					4.4194e-11	1.0012e-10	1	0	A	214171246	A	A	214171246	2	1	154	1	0	0	0	0	0	0	0	1	12622	639	23	3		3	PROX1	1	214171246	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1025068	214171246	35079375	82	27929											
ESRRG	2104	broad.mit.edu	37	chr1	216850521	216850521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actaaacacagtctcttgggCatcgagttgagcatgtattc	11	12	9	9	1	1	1	0	1	1	0	4	2	1	1	0	1	2	4	0	1	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:216850521C>T	uc001hkw.1	-	2	535	c.369G>A	c.(367-369)ATG>ATA	p.M123I	ESRRG_uc001hky.1_Missense_Mutation_p.M100I|ESRRG_uc009xdp.1_Missense_Mutation_p.M100I|ESRRG_uc001hkz.1_Missense_Mutation_p.M100I|ESRRG_uc010puc.1_Missense_Mutation_p.M100I|ESRRG_uc001hla.1_Missense_Mutation_p.M100I|ESRRG_uc001hlb.1_Missense_Mutation_p.M100I|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Missense_Mutation_p.M100I|ESRRG_uc001hld.1_Missense_Mutation_p.M100I|ESRRG_uc001hkx.1_Missense_Mutation_p.M128I|ESRRG_uc009xdo.1_Missense_Mutation_p.M100I|ESRRG_uc001hle.1_Missense_Mutation_p.M100I	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	123					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	GTCTCTTGGGCATCGAGTTGA	0.498													20	79					0	0	0	0	T	216850521	T	T	216850521	3	4	154	1	0	0	0	0	1	0	0	0	5286	710	25	4	1031	4	ESRRG	1	216850521	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2679275	216850521	32400100	83	27930											
RAB3GAP2	25782	broad.mit.edu	37	chr1	220355610	220355610	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaccttaccaacaacagctGagggctaagaccagccgact	15	5	8	13	1	0	2	0	1	0	1	0	3	0	2	4	1	6	2	4	1	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:220355610G>C	uc010puk.1	-	21	2463	c.2299C>G	c.(2299-2301)CAG>GAG	p.Q767E	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.Q347E	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	767					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		AACAACAGCTGAGGGCTAAGA	0.408													14	93					0	0	0	0	C	220355610	C	C	220355610	3	2	154	1	0	0	0	0	1	0	0	0	13001	1299	45	2	1942	2	RAB3GAP2	1	220355610	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3505089	220355610	28895011	84	27931											
DISP1	84976	broad.mit.edu	37	chr1	223176180	223176180	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggaactcttctgacggcGtgactaccatcaccgggatt	9	10	10	12	3	3	2	1	2	2	0	3	4	3	4	2	3	2	0	2	3	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:223176180G>T	uc001hnu.1	+	8	1588	c.1441G>T	c.(1441-1443)GTG>TTG	p.V481L		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	481					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TTCTGACGGCGTGACTACCAT	0.418													24	74					4.26978e-12	9.78653e-12	1	0	T	223176180	T	T	223176180	3	4	154	1	0	0	0	0	1	0	0	0	4561	1145	40	3	1467	3	DISP1	1	223176180	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2820570	223176180	26074441	85	27932											
CAPN2	824	broad.mit.edu	37	chr1	223933090	223933090	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagctgctctttgtgcattCagccgaagggagcgagttct	7	11	14	9	2	3	0	1	0	2	0	3	4	3	2	1	2	5	4	1	2	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:223933090C>G	uc001hob.3	+	4	733	c.509C>G	c.(508-510)TCA>TGA	p.S170*	CAPN2_uc010puy.1_Nonsense_Mutation_p.S92*	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	170	Calpain catalytic.				proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		TTTGTGCATTCAGCCGAAGGG	0.612													3	79					0	0	0	0	G	223933090	G	G	223933090	4	3	154	1	0	0	0	0	0	1	0	0	2639	838	29	2	530	2	CAPN2	1	223933090	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	756910	223933090	25317531	86	27933											
LEFTY1	10637	broad.mit.edu	37	chr1	226076549	226076549	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggctgaacctctttccgcggGagcggtccccgtggctgcgc	3	8	15	15	5	1	1	0	1	1	0	3	2	3	2	4	4	3	2	4	4	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:226076549G>C	uc001hpo.2	-	1	288	c.218C>G	c.(217-219)TCC>TGC	p.S73C	LEFTY1_uc010pvj.1_Intron|LEFTY1_uc009xej.1_Missense_Mutation_p.S73C	NM_020997	NP_066277	O75610	LFTY1_HUMAN	left-right determination, factor B	73					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					CTTTCCGCGGGAGCGGTCCCC	0.692													12	31					0	0	0	0	C	226076549	C	C	226076549	3	2	154	1	0	0	0	0	1	0	0	0	8755	1174	41	2	898	2	LEFTY1	1	226076549	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2143459	226076549	23174072	87	27934											
GJC2	57165	broad.mit.edu	37	chr1	228346341	228346341	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacctgggcttgggcagcgcGcaggacgcggtgcgcggccg	4	4	19	14	7	0	0	0	0	0	0	0	1	0	1	2	5	2	3	2	5	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:228346341G>C	uc001hsk.2	+	2	1057	c.882G>C	c.(880-882)GCG>GCC	p.A294A		NM_020435	NP_065168	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	294	Cytoplasmic (Potential).				cell death	connexon complex|integral to membrane					0		Prostate(94;0.0405)				TGGGCAGCGCGCAGGACGCGG	0.542													14	37					0	0	0	0	C	228346341	C	C	228346341	2	2	154	1	0	0	0	0	0	0	0	1	6452	1074	38	3		3	GJC2	1	228346341	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2269792	228346341	20904280	88	27935											
C1orf124	83932	broad.mit.edu	37	chr1	231488530	231488530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgctgtaagacctaattCtaaaatcaaggtgaaatttg	17	12	7	5	0	2	2	1	1	1	1	2	2	2	2	1	1	1	2	1	1	7	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:231488530C>G	uc001hur.2	+	5	1341	c.893C>G	c.(892-894)TCT>TGT	p.S298C	C1orf124_uc001hus.2_3'UTR|C1orf124_uc001hut.2_3'UTR	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	298					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				AGACCTAATTCTAAAATCAAG	0.353													3	41					0	0	0	0	G	231488530	G	G	231488530	3	3	154	1	0	0	0	0	1	0	0	0	2001	913	32	2	946	2	C1orf124	1	231488530	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3142189	231488530	17762091	89	27936											
RYR2	6262	broad.mit.edu	37	chr1	237777906	237777906	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctctcatcaagcttttctaTaccctgctgatcatgggcat	8	14	6	13	0	4	1	3	1	2	0	5	1	4	1	2	1	3	3	2	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:237777906T>C	uc001hyl.1	+	37	5598	c.5478T>C	c.(5476-5478)TAT>TAC	p.Y1826Y		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1826	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCTTTTCTATACCCTGCTGA	0.493													47	181					0	0	0	0	C	237777906	C	C	237777906	2	2	154	1	0	0	0	0	0	0	0	1	13834	1413	49	5		5	RYR2	1	237777906	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	6289376	237777906	11472715	90	27937											
FMN2	56776	broad.mit.edu	37	chr1	240255773	240255773	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccaagactccagacctcAgcctctcggcggacgaggcc	9	5	10	17	3	3	2	2	0	1	2	5	4	4	3	5	3	1	0	5	3	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:240255773A>G	uc010pyd.1	+	1	589	c.364A>G	c.(364-366)AGC>GGC	p.S122G	FMN2_uc010pye.1_Missense_Mutation_p.S122G	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	122					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCCAGACCTCAGCCTCTCGGC	0.687													4	11					0	0	0	0	G	240255773	G	G	240255773	3	3	154	1	0	0	0	0	1	0	0	0	5982	188	7	5	366	5	FMN2	1	240255773	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	2477867	240255773	8994848	91	27938											
FMN2	56776	broad.mit.edu	37	chr1	240492684	240492684	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccaacttttcagagcgagtCttttgcatcctgttccagtc	7	14	7	13	1	2	1	1	0	1	1	5	2	4	1	3	0	3	2	3	0	1	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:240492684C>G	uc010pyd.1	+	10	4578	c.4353C>G	c.(4351-4353)GTC>GTG	p.V1451V	FMN2_uc010pye.1_Silent_p.V1455V|FMN2_uc010pyf.1_Silent_p.V97V|FMN2_uc010pyg.1_Silent_p.V47V	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1451	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGAGCGAGTCTTTTGCATCC	0.373													9	118					0	0	0	0	G	240492684	G	G	240492684	2	3	154	1	0	0	0	0	0	0	0	1	5982	900	32	2		2	FMN2	1	240492684	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	236911	240492684	8757937	92	27939											
CHML	1122	broad.mit.edu	37	chr1	241798317	241798317	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctacataacgactaacatctGatttgattaaaagatcaatt	17	13	4	7	1	2	3	1	2	1	1	2	4	2	3	0	0	3	0	0	0	6	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:241798317G>C	uc001hzd.2	-	1	916	c.752C>G	c.(751-753)TCA>TGA	p.S251*	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	251					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			ACTAACATCTGATTTGATTAA	0.343													7	63					0	0	0	0	C	241798317	C	C	241798317	4	2	154	1	0	0	0	0	0	1	0	0	3366	1294	45	2	1222	2	CHML	1	241798317	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1305633	241798317	7452304	93	27940											
NLRP3	114548	broad.mit.edu	37	chr1	247588696	247588696	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaagggccatggactatttcCccaagattgagatcaatctc	13	10	8	10	0	2	2	1	1	1	2	4	4	3	3	3	2	0	0	3	2	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:247588696C>A	uc001icr.2	+	5	2089	c.1951C>A	c.(1951-1953)CCC>ACC	p.P651T	NLRP3_uc001ics.2_Missense_Mutation_p.P651T|NLRP3_uc001icu.2_Missense_Mutation_p.P651T|NLRP3_uc001icw.2_Missense_Mutation_p.P651T|NLRP3_uc001icv.2_Missense_Mutation_p.P651T|NLRP3_uc010pyw.1_Missense_Mutation_p.P649T|NLRP3_uc001ict.1_Missense_Mutation_p.P649T	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	651					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GGACTATTTCCCCAAGATTGA	0.493													9	47					3.07112e-06	6.27794e-06	1	0	A	247588696	A	A	247588696	3	1	154	1	0	0	0	0	1	0	0	0	10532	623	22	4	1961	4	NLRP3	1	247588696	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	5790379	247588696	1661925	94	27941											
OR2T33	391195	broad.mit.edu	37	chr1	248437009	248437009	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atgagggaattgccaaacagGgaggtcaaaacgatactcag	16	6	12	7	1	2	1	2	1	0	0	2	4	2	3	1	3	4	0	1	3	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:248437009G>T	uc010pzi.1	-	1	108	c.108C>A	c.(106-108)TCC>TCA	p.S36S		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGCCAAACAGGGAGGTCAAAA	0.488													21	83					3.1745e-13	7.41137e-13	1	0	T	248437009	T	T	248437009	2	4	154	1	0	0	0	0	0	0	0	1	11078	1219	43	4		4	OR2T33	1	248437009	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	848313	248437009	813612	95	27942											
OR2T3	343173	broad.mit.edu	37	chr1	248637210	248637210	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgagttttttctgtgagactCctgccctgctgaagctctcc	5	15	9	12	0	2	3	0	3	2	1	4	4	3	3	3	0	3	3	3	0	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:248637210C>T	uc001iel.1	+	1	559	c.559C>T	c.(559-561)CCT>TCT	p.P187S		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGTGAGACTCCTGCCCTGCT	0.512													91	205					0	0	0	0	T	248637210	T	T	248637210	3	4	154	1	0	0	0	0	1	0	0	0	11077	855	30	2	561	2	OR2T3	1	248637210	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	200201	248637210	613411	96	27943											
OR2G6	391211	broad.mit.edu	37	chr1	248685139	248685139	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaatgtacttcttcctcagCaacctctcgtgtgtggacat	8	13	7	13	1	3	0	1	0	2	0	5	1	4	1	3	1	3	2	3	1	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr1:248685139C>A	uc001ien.1	+	1	192	c.192C>A	c.(190-192)AGC>AGA	p.S64R		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCTTCCTCAGCAACCTCTCGT	0.483													33	63					6.50621e-10	1.44418e-09	1	0	A	248685139	A	A	248685139	3	1	154	1	0	0	0	0	1	0	0	0	11054	709	25	4	194	4	OR2G6	1	248685139	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	47929	248685139	565482	97	27944											
ACP1	52	broad.mit.edu	37	chr2	271881	271881	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaggtaacatttgtcgatCacccattgcagaagcagttt	13	12	8	8	1	1	1	1	0	0	1	2	2	1	1	1	1	3	4	1	1	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:271881C>T	uc002qwg.2	+	2	155	c.59C>T	c.(58-60)TCA>TTA	p.S20L	ACP1_uc002qwd.2_Missense_Mutation_p.S20L|ACP1_uc002qwe.3_RNA|ACP1_uc002qwh.2_RNA|ACP1_uc002qwf.2_Missense_Mutation_p.S20L	NM_007099	NP_009030	P24666	PPAC_HUMAN	acid phosphatase 1, soluble isoform b	20				CLGNICRS -> PARREAAR (in Ref. 5; AAB27085).		cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity			skin(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)		ATTTGTCGATCACCCATTGCA	0.448													7	80					0	0	0	0	T	271881	T	T	271881	3	4	154	1	0	0	0	0	1	0	0	0	162	838	29	2	65	2	ACP1	2	271881	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08		271881	242927492	98	27945											
KIDINS220	57498	broad.mit.edu	37	chr2	8871289	8871289	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggctatgtgggattcccCgctttccgctgtgactgtca	5	13	11	12	2	2	1	2	1	0	0	4	2	4	2	3	2	0	3	3	2	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:8871289C>G	uc002qzc.2	-	30	5059	c.4877G>C	c.(4876-4878)CGG>CCG	p.R1626P	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Missense_Mutation_p.R1527P|KIDINS220_uc002qzb.2_Missense_Mutation_p.R480P	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1626	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGGGATTCCCCGCTTTCCGCT	0.483													8	45					0	0	0	0	G	8871289	G	G	8871289	3	3	154	1	0	0	0	0	1	0	0	0	8310	652	23	3	442	3	KIDINS220	2	8871289	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	8599408	8871289	234328084	99	27946											
GEN1	348654	broad.mit.edu	37	chr2	17954379	17954379	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaggaaagcttgctgttgtGagggattcccattccatgag	9	12	12	8	0	1	2	1	2	0	0	3	4	3	4	2	2	2	3	2	2	1	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:17954379G>C	uc002rct.2	+	9	1043	c.970G>C	c.(970-972)GAG>CAG	p.E324Q	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.E324Q|GEN1_uc002rcu.2_Missense_Mutation_p.E324Q	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	324					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTGCTGTTGTGAGGGATTCCC	0.214								Homologous_recombination					4	34					0	0	0	0	C	17954379	C	C	17954379	3	2	154	1	0	0	0	0	1	0	0	0	6372	1291	45	2	1000	2	GEN1	2	17954379	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	9083090	17954379	225244994	100	27947											
APOB	338	broad.mit.edu	37	chr2	21231102	21231102	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgctatccagggtaagctGattgtttatcttgacaatca	10	15	9	7	0	2	2	1	2	1	0	3	2	3	2	1	1	2	5	1	1	4	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:21231102G>A	uc002red.2	-	26	8766	c.8638C>T	c.(8638-8640)CAG>TAG	p.Q2880*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2880					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGGGTAAGCTGATTGTTTATC	0.408													17	165					0	0	0	0	A	21231102	A	A	21231102	4	1	154	1	0	0	0	0	0	1	0	0	785	1299	45	2	5069	2	APOB	2	21231102	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3276723	21231102	221968271	101	27948											
DNMT3A	1788	broad.mit.edu	37	chr2	25467409	25467409	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggccacaacagcctcacCtgcagcagttgttgtttccg	8	9	11	13	1	1	0	1	0	0	0	2	1	2	1	4	2	4	5	4	2	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:25467409C>A	uc002rgc.2	-	14	1924	c.1667G>T	c.(1666-1668)AGG>ATG	p.R556M	DNMT3A_uc002rgd.2_Missense_Mutation_p.R556M|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.R367M	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	556	PHD-type; atypical.|Interaction with the PRC2/EED-EZH2 complex (By similarity).|ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAGCCTCACCTGCAGCAGTT	0.652			Mis|F|N|S		AML								8	41					1.12685e-05	2.25627e-05	1	0	A	25467409	A	A	25467409	3	1	154	1	0	0	0	0	1	0	0	0	4698	695	24	4	1111	4	DNMT3A	2	25467409	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4236307	25467409	217731964	102	27949											
HADHB	3032	broad.mit.edu	37	chr2	26502173	26502173	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttctgatgtggtacccttCaaagtaccaggtgaaatgaa	12	12	9	8	0	2	3	1	3	1	0	2	3	2	3	2	2	2	2	2	2	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:26502173C>T	uc002rgz.2	+	9	1052	c.801C>T	c.(799-801)TTC>TTT	p.F267F	HADHB_uc010ykv.1_Silent_p.F245F|HADHB_uc010ykw.1_Silent_p.F252F|HADHB_uc002rha.2_Intron|HADHB_uc010ykx.1_Silent_p.F193F	NM_000183	NP_000174	P55084	ECHB_HUMAN	mitochondrial trifunctional protein, beta	267			Missing (in TFP deficiency).		fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGTACCCTTCAAAGTACCAG	0.433													6	71					0	0	0	0	T	26502173	T	T	26502173	2	4	154	1	0	0	0	0	0	0	0	1	6983	825	29	2		2	HADHB	2	26502173	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1034764	26502173	216697200	103	27950											
IFT172	26160	broad.mit.edu	37	chr2	27670397	27670397	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaccagctgtttgacactCtgggctgcagagcgcgtggc	6	9	13	13	2	2	2	1	1	1	1	2	2	2	2	1	2	3	4	1	2	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:27670397C>G	uc002rku.2	-	42	4695	c.4644G>C	c.(4642-4644)CAG>CAC	p.Q1548H	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1548					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					GTTTGACACTCTGGGCTGCAG	0.498													19	190					0	0	0	0	G	27670397	G	G	27670397	3	3	154	1	0	0	0	0	1	0	0	0	7596	912	32	2	633	2	IFT172	2	27670397	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1168224	27670397	215528976	104	27951											
C2orf71	388939	broad.mit.edu	37	chr2	29296154	29296154	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggctctctagctgcctcAgagccctcaggaggcgttca	7	8	11	15	1	4	1	3	0	1	1	5	2	4	2	3	3	3	3	3	3	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:29296154A>G	uc002rmt.1	-	1	974	c.974T>C	c.(973-975)CTG>CCG	p.L325P		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	325					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						TAGCTGCCTCAGAGCCCTCAG	0.577													20	89					0	0	0	0	G	29296154	G	G	29296154	3	3	154	1	0	0	0	0	1	0	0	0	2201	188	7	5	2900	5	C2orf71	2	29296154	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	1625757	29296154	213903219	105	27952											
BIRC6	57448	broad.mit.edu	37	chr2	32735635	32735635	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaagactaaatggactctCttctgactctacgatagata	13	12	8	8	1	3	3	0	1	3	2	4	6	3	5	0	2	1	0	0	2	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:32735635C>A	uc010ezu.2	+	53	10414	c.10280C>A	c.(10279-10281)TCT>TAT	p.S3427Y		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3427					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					AATGGACTCTCTTCTGACTCT	0.343													13	152					8.60227e-14	2.02991e-13	1	0	A	32735635	A	A	32735635	3	1	154	1	0	0	0	0	1	0	0	0	1441	913	32	2	10490	2	BIRC6	2	32735635	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3439481	32735635	210463738	106	27953											
BIRC6	57448	broad.mit.edu	37	chr2	32773002	32773002	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactggctttggaacaggctCtacagcttctgggtgggatg	7	11	15	8	0	2	0	0	0	2	0	2	3	2	2	0	5	3	3	0	5	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:32773002C>T	uc010ezu.2	+	64	13030	c.12896C>T	c.(12895-12897)TCT>TTT	p.S4299F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4299					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GGAACAGGCTCTACAGCTTCT	0.428													8	31					0	0	0	0	T	32773002	T	T	32773002	3	4	154	1	0	0	0	0	1	0	0	0	1441	913	32	2	13150	2	BIRC6	2	32773002	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	37367	32773002	210426371	107	27954											
LTBP1	4052	broad.mit.edu	37	chr2	33482491	33482491	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctgttgctaaaagtactCatcctccacctctcccagcc	10	10	4	17	0	2	0	1	0	1	0	5	0	4	0	6	0	4	3	6	0	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:33482491C>T	uc002ros.2	+	12	2308	c.2308C>T	c.(2308-2310)CAT>TAT	p.H770Y	LTBP1_uc002rot.2_Missense_Mutation_p.H444Y|LTBP1_uc002rou.2_Missense_Mutation_p.H444Y|LTBP1_uc002rov.2_Intron|LTBP1_uc010ymz.1_Missense_Mutation_p.H444Y|LTBP1_uc010yna.1_Intron	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	770					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TAAAAGTACTCATCCTCCACC	0.547													11	43					0	0	0	0	T	33482491	T	T	33482491	3	4	154	1	0	0	0	0	1	0	0	0	9123	826	29	2	2409	2	LTBP1	2	33482491	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	709489	33482491	209716882	108	27955											
RASGRP3	25780	broad.mit.edu	37	chr2	33752432	33752432	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactagtctccctgcagaatGcctctcaccacttagaaccc	11	9	5	16	0	2	2	1	0	2	2	4	2	2	2	4	0	4	1	4	0	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:33752432G>A	uc002rox.2	+	11	1663	c.1036G>A	c.(1036-1038)GCC>ACC	p.A346T	RASGRP3_uc010ync.1_Missense_Mutation_p.A346T|RASGRP3_uc002roy.2_Missense_Mutation_p.A346T	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	346	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					CCTGCAGAATGCCTCTCACCA	0.468													9	29					0	0	0	0	A	33752432	A	A	33752432	3	1	154	1	0	0	0	0	1	0	0	0	13141	1319	46	4	1066	4	RASGRP3	2	33752432	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	269941	33752432	209446941	109	27956											
LRPPRC	10128	broad.mit.edu	37	chr2	44209515	44209515	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaagaaaaagtggactcctCttgaatatctttttctttgg	12	15	8	6	0	3	3	0	1	3	2	4	4	4	4	1	2	0	0	1	2	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:44209515C>G	uc002rtr.2	-	2	266	c.208G>C	c.(208-210)GAG>CAG	p.E70Q	LRPPRC_uc010yob.1_Intron|LRPPRC_uc010faw.1_Missense_Mutation_p.E44Q	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	70					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTGGACTCCTCTTGAATATCT	0.383													3	67					0	0	0	0	G	44209515	G	G	44209515	3	3	154	1	0	0	0	0	1	0	0	0	9015	922	32	2	4124	2	LRPPRC	2	44209515	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	10457083	44209515	198989858	110	27957											
PSME4	23198	broad.mit.edu	37	chr2	54148034	54148034	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaaaatgcttgccttgatagGaaagtattcagaaggaggct	14	10	12	5	0	1	2	1	1	0	1	1	5	1	4	1	3	2	3	1	3	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:54148034G>C	uc002rxp.2	-	18	2310	c.2254C>G	c.(2254-2256)CCT>GCT	p.P752A	PSME4_uc010yop.1_Missense_Mutation_p.P638A|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Missense_Mutation_p.P127A|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	752					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GCCTTGATAGGAAAGTATTCA	0.363													7	66					0	0	0	0	C	54148034	C	C	54148034	3	2	154	1	0	0	0	0	1	0	0	0	12771	1174	41	2	3393	2	PSME4	2	54148034	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	9938519	54148034	189051339	111	27958											
PLEK	5341	broad.mit.edu	37	chr2	68609701	68609701	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatttgtccatgaaagacacTgaaaaaggaataaaagaact	20	9	7	5	0	0	4	0	2	0	2	1	5	1	5	1	1	1	0	1	1	8	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:68609701T>A	uc002sen.3	+	4	570	c.408T>A	c.(406-408)ACT>ACA	p.T136T	PLEK_uc010fde.2_Silent_p.T136T	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	136	DEP.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		TGAAAGACACTGAAAAAGGAA	0.348													28	70					0	0	0	0	A	68609701	A	A	68609701	2	1	154	1	0	0	0	0	0	0	0	1	12108	1567	55	5		5	PLEK	2	68609701	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	14461667	68609701	174589672	112	27959											
ALMS1	7840	broad.mit.edu	37	chr2	73718601	73718601	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaaggacattccaatccagAggggaccccagtatttgcag	12	7	11	11	1	0	1	0	0	0	1	2	4	2	3	4	3	1	2	4	3	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:73718601A>G	uc002sje.1	+	12	9629	c.9518A>G	c.(9517-9519)GAG>GGG	p.E3173G	ALMS1_uc002sjf.1_Missense_Mutation_p.E3129G|ALMS1_uc002sjg.2_Missense_Mutation_p.E2559G|ALMS1_uc002sjh.1_Missense_Mutation_p.E2559G	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3171					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TCCAATCCAGAGGGGACCCCA	0.413													3	57					0	0	0	0	G	73718601	G	G	73718601	3	3	154	1	0	0	0	0	1	0	0	0	535	304	11	5	9550	5	ALMS1	2	73718601	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	5108900	73718601	169480772	113	27960											
ALMS1	7840	broad.mit.edu	37	chr2	73799886	73799886	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaactgtccttggtggacCgacttgatcgtttggctaaa	10	12	11	8	2	0	2	0	1	0	1	2	4	1	3	2	3	1	2	2	3	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:73799886C>G	uc002sje.1	+	18	10996	c.10885C>G	c.(10885-10887)CGA>GGA	p.R3629G	ALMS1_uc002sjf.1_Missense_Mutation_p.R3585G|ALMS1_uc002sjg.2_Missense_Mutation_p.R3015G|ALMS1_uc002sjh.1_Missense_Mutation_p.R3015G	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3627					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CTTGGTGGACCGACTTGATCG	0.468													16	58					0	0	0	0	G	73799886	G	G	73799886	3	3	154	1	0	0	0	0	1	0	0	0	535	644	23	3	10941	3	ALMS1	2	73799886	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	81285	73799886	169399487	114	27961											
LRRTM4	80059	broad.mit.edu	37	chr2	77746095	77746095	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgatggatattaatgatatCcacgcattgacagtttcctg	11	14	9	7	1	0	3	0	3	0	0	2	4	2	4	2	1	0	2	2	1	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:77746095C>A	uc002snr.2	-	3	1315	c.900G>T	c.(898-900)TGG>TGT	p.W300C	LRRTM4_uc002snq.2_Missense_Mutation_p.W300C|LRRTM4_uc002sns.2_Missense_Mutation_p.W300C|LRRTM4_uc002snt.2_Missense_Mutation_p.W301C	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	300	Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		TTAATGATATCCACGCATTGA	0.373													4	18					2.56e-06	5.24531e-06	1	0	A	77746095	A	A	77746095	3	1	154	1	0	0	0	0	1	0	0	0	9092	856	30	2	886	2	LRRTM4	2	77746095	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3946209	77746095	165453278	115	27962											
C2orf68	388969	broad.mit.edu	37	chr2	85836166	85836166	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtgtgtgccgacaccttctCactcacctttcctgggtcat	5	13	8	15	2	3	0	3	0	1	0	5	1	4	0	4	1	1	0	4	1	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:85836166C>G	uc002sqc.2	-	4	475	c.403G>C	c.(403-405)GAG>CAG	p.E135Q	USP39_uc002sqb.2_Intron	NM_001013649	NP_001013671	Q2NKX9	CB068_HUMAN	hypothetical protein LOC388969	135										central_nervous_system(1)	1						GACACCTTCTCACTCACCTTT	0.577													5	45					0	0	0	0	G	85836166	G	G	85836166	3	3	154	1	0	0	0	0	1	0	0	0	2197	835	29	2	101	2	C2orf68	2	85836166	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	8090071	85836166	157363207	116	27963											
SMYD1	150572	broad.mit.edu	37	chr2	88402603	88402603	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggaagtggtgaaggagatGatacaattctccaaggatac	15	8	12	6	0	1	3	0	2	1	1	2	6	1	5	1	4	2	0	1	4	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:88402603G>C	uc002ssr.2	+	7	917	c.915G>C	c.(913-915)ATG>ATC	p.M305I	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Missense_Mutation_p.M1I	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						TGAAGGAGATGATACAATTCT	0.453													4	46					0	0	0	0	C	88402603	C	C	88402603	3	2	154	1	0	0	0	0	1	0	0	0	14885	1290	45	2	941	2	SMYD1	2	88402603	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2566437	88402603	154796770	117	27964											
INPP4A	3631	broad.mit.edu	37	chr2	99180077	99180077	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgagcctgcagtaccgcCgtgacgtggtcttctgccag	6	9	12	14	3	2	2	0	2	2	0	2	2	2	2	5	1	4	2	5	1	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:99180077C>T	uc002syy.2	+	19	2413	c.2020C>T	c.(2020-2022)CGT>TGT	p.R674C	INPP4A_uc010yvj.1_Missense_Mutation_p.R635C|INPP4A_uc010yvk.1_Missense_Mutation_p.R635C|INPP4A_uc002syx.2_Missense_Mutation_p.R669C|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	674					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						GCAGTACCGCCGTGACGTGGT	0.622													5	39					0	0	0	0	T	99180077	T	T	99180077	3	4	154	1	0	0	0	0	1	0	0	0	7791	652	23	1	2086	1	INPP4A	2	99180077	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	10777474	99180077	144019296	118	27965											
TGFBRAP1	9392	broad.mit.edu	37	chr2	105897018	105897018	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctcgttcaggtagctcatGaggaagcgtttgcacttggc	8	11	12	10	2	2	1	2	1	0	0	3	2	2	2	1	3	3	5	1	3	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:105897018G>A	uc002tcq.2	-	6	1368	c.1284C>T	c.(1282-1284)CTC>CTT	p.L428L	TGFBRAP1_uc010fjc.2_Silent_p.L198L|TGFBRAP1_uc002tcr.3_Silent_p.L428L	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	428					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						GGTAGCTCATGAGGAAGCGTT	0.572													18	80					0	0	0	0	A	105897018	A	A	105897018	2	1	154	1	0	0	0	0	0	0	0	1	15890	1277	45	2		2	TGFBRAP1	2	105897018	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	6716941	105897018	137302355	119	27966											
ST6GAL2	84620	broad.mit.edu	37	chr2	107450599	107450599	+	Frame_Shift_Del	DEL	G	-	-																															atctcaaaaccgcatcatgaGaatctaagggcacataagtg																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:107450599delG	uc002tdq.2	-	3	1066	c.947delC	c.(946-948)TCTfs	p.S316fs	ST6GAL2_uc002tdr.2_Frame_Shift_Del_p.S316fs|ST6GAL2_uc002tds.3_Frame_Shift_Del_p.S316fs	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	316	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CGCATCATGAGAATCTAAGGG	0.363													---	---	---								-	107450599	-	-	107450599	7	5	154	1	0	1	0	1	0	0	0	0	15288	942	33	0	745	0	ST6GAL2	2	107450599	Frame_Shift_Del	DEL	G	TCGA-CR-7388-01A-11D-2012-08	1553581	107450599	135748774	120	27967											
SH3RF3	344558	broad.mit.edu	37	chr2	109988086	109988086	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagtggatgagaactgggcGgaaggcatgctgggagacaa	13	5	18	5	1	0	3	0	1	0	3	0	7	0	5	0	5	2	2	0	5	3	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:109988086G>T	uc010ywt.1	+	3	894	c.894G>T	c.(892-894)GCG>GCT	p.A298A		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	298	SH3 2.						zinc ion binding			ovary(1)	1						AGAACTGGGCGGAAGGCATGC	0.577													9	35					1.76689e-08	3.79731e-08	1	0	T	109988086	T	T	109988086	2	4	154	1	0	0	0	0	0	0	0	1	14325	1103	39	3		3	SH3RF3	2	109988086	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2537487	109988086	133211287	121	27968											
GLI2	2736	broad.mit.edu	37	chr2	121743959	121743959	+	Frame_Shift_Del	DEL	C	-	-																															tggagatgccggggacggggCccgggagcctgggagacctg																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:121743959delC	uc010flp.2	+	12	2092	c.2062delC	c.(2062-2064)CCCfs	p.P688fs	GLI2_uc002tmq.1_Frame_Shift_Del_p.P360fs|GLI2_uc002tmr.1_Frame_Shift_Del_p.P343fs|GLI2_uc002tmt.3_Frame_Shift_Del_p.P360fs|GLI2_uc002tmu.3_Frame_Shift_Del_p.P343fs|GLI2_uc002tmw.1_Frame_Shift_Del_p.P671fs	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	688					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GGGGACGGGGCCCGGGAGCCT	0.711													---	---	---								-	121743959	-	-	121743959	7	5	154	1	0	1	0	1	0	0	0	0	6475	739	26	0	2108	0	GLI2	2	121743959	Frame_Shift_Del	DEL	C	TCGA-CR-7388-01A-11D-2012-08	11755873	121743959	121455414	122	27969											
MYO7B	4648	broad.mit.edu	37	chr2	128335742	128335742	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtgaggggctcaacgacgCcaaggactacgcccacatcc	10	5	11	15	3	1	1	1	1	0	0	2	3	2	2	3	3	2	1	3	3	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:128335742C>T	uc002top.2	+	9	937	c.884C>T	c.(883-885)GCC>GTC	p.A295V		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	295	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTCAACGACGCCAAGGACTAC	0.632													10	20					0	0	0	0	T	128335742	T	T	128335742	3	4	154	1	0	0	0	0	1	0	0	0	10136	739	26	4	914	4	MYO7B	2	128335742	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6591783	128335742	114863631	123	27970											
FAM123C	205147	broad.mit.edu	37	chr2	131520753	131520753	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagccagctccatcgacacaGgcacccccaagagcgagcag	13	2	10	16	2	0	1	0	0	0	1	2	3	1	1	4	1	4	3	4	1	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:131520753G>C	uc002trw.2	+	2	1298	c.1108G>C	c.(1108-1110)GGC>CGC	p.G370R	FAM123C_uc010fmv.2_Missense_Mutation_p.G370R|FAM123C_uc010fms.1_Missense_Mutation_p.G370R|FAM123C_uc010fmt.1_Missense_Mutation_p.G370R|FAM123C_uc010fmu.1_Missense_Mutation_p.G370R	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	370										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CATCGACACAGGCACCCCCAA	0.627													6	35					0	0	0	0	C	131520753	C	C	131520753	3	2	154	1	0	0	0	0	1	0	0	0	5452	1000	35	4	1110	4	FAM123C	2	131520753	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3185011	131520753	111678620	124	27971											
ZEB2	9839	broad.mit.edu	37	chr2	145147399	145147399	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcctcgcgctccgccgcttcCcgctcctccgcctcccgctt	0	9	8	24	7	0	0	0	0	0	0	6	0	5	0	8	0	0	4	8	0	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:145147399C>T	uc002tvu.2	-	10	3744	c.3264G>A	c.(3262-3264)CGG>CGA	p.R1088R	ZEB2_uc002tvv.2_Silent_p.R1082R|ZEB2_uc010zbm.1_Silent_p.R1059R|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	1088	Glu-rich (acidic).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		CCGCCGCTTCCCGCTCCTCCG	0.592													8	68					0	0	0	0	T	145147399	T	T	145147399	2	4	154	1	0	0	0	0	0	0	0	1	17691	610	22	4		4	ZEB2	2	145147399	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	13626646	145147399	98051974	125	27972											
NMI	9111	broad.mit.edu	37	chr2	152138558	152138558	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaatttcatcaattagtccCttaaaaatatcaaatggtac	16	14	4	7	0	3	0	3	0	0	0	4	0	4	0	1	1	1	2	1	1	9	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:152138558C>T	uc002txi.2	-	3	412	c.82_splice	c.e3-1	p.G28_splice	NMI_uc010zbx.1_Splice_Site_p.G28_splice|NMI_uc002txj.2_Intron	NM_004688	NP_004679	Q13287	NMI_HUMAN	N-myc and STAT interactor						inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity				0				BRCA - Breast invasive adenocarcinoma(221;0.0571)		CAATTAGTCCCTTAAAAATAT	0.333													5	16					0	0	0	0	T	152138558	T	T	152138558	5	4	154	1	0	0	0	0	0	0	1	0	10551	695	24	4	866	4	NMI	2	152138558	Splice_Site	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6991159	152138558	91060815	126	27973											
BAZ2B	29994	broad.mit.edu	37	chr2	160294955	160294955	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaccaaagataaaggtttCacattggacaccaatcccgt	14	11	6	10	1	1	1	1	0	0	1	2	2	2	2	3	2	1	1	3	2	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:160294955C>G	uc002uao.2	-	8	1504	c.1152G>C	c.(1150-1152)GTG>GTC	p.V384V	BAZ2B_uc002uap.2_Silent_p.V382V|BAZ2B_uc002uas.1_Silent_p.V321V|BAZ2B_uc002uau.1_Silent_p.V382V|BAZ2B_uc002uaq.1_Silent_p.V312V|BAZ2B_uc002uat.3_3'UTR|BAZ2B_uc010fop.1_Silent_p.V382V	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						ATAAAGGTTTCACATTGGACA	0.393													22	62					0	0	0	0	G	160294955	G	G	160294955	2	3	154	1	0	0	0	0	0	0	0	1	1334	813	29	2		2	BAZ2B	2	160294955	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	8156397	160294955	82904418	127	27974											
ITGB6	3694	broad.mit.edu	37	chr2	160994114	160994114	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccttgcaggaatctgtgctCagcatgtcctcgccacactc	7	11	8	15	1	2	0	1	0	1	0	6	1	4	1	3	1	3	3	3	1	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:160994114C>G	uc002ubh.2	-	10	1507	c.1491G>C	c.(1489-1491)CTG>CTC	p.L497L	ITGB6_uc010fou.2_Silent_p.L497L|ITGB6_uc010zcq.1_Silent_p.L455L|ITGB6_uc010fov.1_Silent_p.L497L	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	497	Extracellular (Potential).|Cysteine-rich tandem repeats.|I.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						AATCTGTGCTCAGCATGTCCT	0.602													4	55					0	0	0	0	G	160994114	G	G	160994114	2	3	154	1	0	0	0	0	0	0	0	1	7938	813	29	2		2	ITGB6	2	160994114	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	699159	160994114	82205259	128	27975											
SLC4A10	57282	broad.mit.edu	37	chr2	162711549	162711549	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagccttatgtggctactctTtcattgcacagcttgtttga	8	16	8	9	0	2	1	1	1	1	0	2	1	2	1	1	1	4	4	1	1	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:162711549T>C	uc002ubx.3	+	5	670	c.486T>C	c.(484-486)CTT>CTC	p.L162L	SLC4A10_uc010fpa.1_Silent_p.L174L|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Silent_p.L162L|SLC4A10_uc010zcs.1_Silent_p.L173L	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	162	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TGGCTACTCTTTCATTGCACA	0.388													7	50					0	0	0	0	C	162711549	C	C	162711549	2	2	154	1	0	0	0	0	0	0	0	1	14715	1828	64	5		5	SLC4A10	2	162711549	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1717435	162711549	80487824	129	27976											
DPP4	1803	broad.mit.edu	37	chr2	162891810	162891810	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtttggagaccaccacagaGcagagtaggcactgaagact	13	6	12	10	1	0	5	0	1	0	4	0	6	0	5	2	2	1	4	2	2	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:162891810G>C	uc002ubz.2	-	9	1199	c.638C>G	c.(637-639)GCT>GGT	p.A213G	DPP4_uc010fpb.2_5'UTR	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	213	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	CCACCACAGAGCAGAGTAGGC	0.398													9	42					0	0	0	0	C	162891810	C	C	162891810	3	2	154	1	0	0	0	0	1	0	0	0	4751	971	34	4	1734	4	DPP4	2	162891810	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	180261	162891810	80307563	130	27977											
SCN9A	6335	broad.mit.edu	37	chr2	167159754	167159754	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacagaacacagtcaggatCatgacatcagaaagcttctt	16	8	8	9	0	4	4	3	1	1	3	4	5	4	5	0	1	2	1	0	1	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:167159754C>A	uc010fpl.2	-	7	1088	c.747G>T	c.(745-747)ATG>ATT	p.M249I	SCN9A_uc002udr.1_Missense_Mutation_p.M120I|SCN9A_uc002uds.1_Missense_Mutation_p.M120I|SCN9A_uc002udt.1_Missense_Mutation_p.M120I	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	249	Helical; Name=S5 of repeat I; (Potential).|I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CAGTCAGGATCATGACATCAG	0.393													6	30					0.00198382	0.003734	1	0	A	167159754	A	A	167159754	3	1	154	1	0	0	0	0	1	0	0	0	13990	826	29	2	5270	2	SCN9A	2	167159754	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4267944	167159754	76039619	131	27978											
ABCB11	8647	broad.mit.edu	37	chr2	169791840	169791840	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgaatggctgtcttgaaGggcttctccagctcagtctc	6	14	10	11	0	5	2	1	2	4	0	7	2	5	2	1	2	1	3	1	2	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:169791840G>T	uc002ueo.1	-	23	3036	c.2910C>A	c.(2908-2910)CCC>CCA	p.P970P	ABCB11_uc010zda.1_Silent_p.P412P|ABCB11_uc010zdb.1_Silent_p.P446P	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	970	Cytoplasmic (Potential).|ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTGTCTTGAAGGGCTTCTCCA	0.453													31	124					1.75199e-13	4.11214e-13	1	0	T	169791840	T	T	169791840	2	4	154	1	0	0	0	0	0	0	0	1	42	987	35	4		4	ABCB11	2	169791840	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2632086	169791840	73407533	132	27979											
LRP2	4036	broad.mit.edu	37	chr2	169989114	169989114	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcagcagctggtgaagttggGtttgtctctggaactatctc	7	14	12	8	0	3	1	1	1	2	0	5	2	3	2	0	3	3	4	0	3	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:169989114G>A	uc002ues.2	-	77	13911	c.13698C>T	c.(13696-13698)AAC>AAT	p.N4566N		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4566	Cytoplasmic (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTGAAGTTGGGTTTGTCTCTG	0.408													23	66					0	0	0	0	A	169989114	A	A	169989114	2	1	154	1	0	0	0	0	0	0	0	1	9006	1252	44	4		4	LRP2	2	169989114	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	197274	169989114	73210259	133	27980											
WIPF1	7456	broad.mit.edu	37	chr2	175436931	175436931	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcactggtggggaccccCggttgtgcggacttgattga	5	9	17	10	3	0	2	0	2	0	0	0	4	0	4	2	6	1	2	2	6	0	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:175436931C>A	uc002uiy.2	-	6	934	c.602G>T	c.(601-603)CGG>CTG	p.R201L	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.R201L|WIPF1_uc010fqt.1_Missense_Mutation_p.R201L|WIPF1_uc002ujc.1_Missense_Mutation_p.R201L|WIPF1_uc002uiz.2_Missense_Mutation_p.R201L|WIPF1_uc002ujb.1_Missense_Mutation_p.R201L|WIPF1_uc010zep.1_Missense_Mutation_p.R201L	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	201					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						TGGGGACCCCCGGTTGTGCGG	0.652													18	70					1.28384e-07	2.70622e-07	1	0	A	175436931	A	A	175436931	3	1	154	1	0	0	0	0	1	0	0	0	17435	652	23	3	925	3	WIPF1	2	175436931	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	5447817	175436931	67762442	134	27981											
TTN	7273	broad.mit.edu	37	chr2	179614079	179614079	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtatgaattcagccctgaTgggcttgctgatttttatgg	7	17	11	6	0	1	3	1	3	0	0	1	3	1	3	1	2	2	3	1	2	3	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:179614079T>C	uc002unb.2	-	46	13272	c.13048A>G	c.(13048-13050)ATC>GTC	p.I4350V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGCCCTGATGGGCTTGCTG	0.423													18	99					0	0	0	0	C	179614079	C	C	179614079	3	2	154	1	0	0	0	0	1	0	0	0	16803	1464	51	5	97249	5	TTN	2	179614079	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	4177148	179614079	63585294	135	27982											
MSTN	2660	broad.mit.edu	37	chr2	190926956	190926956	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataggactacttacactctgTaggcatggtaatgattgttt	11	15	9	6	0	1	1	0	1	1	0	1	2	1	2	0	3	2	4	0	3	5	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:190926956T>C	uc002urp.2	-	1	500	c.367A>G	c.(367-369)ACA>GCA	p.T123A		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	123					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TTACACTCTGTAGGCATGGTA	0.398													25	54					0	0	0	0	C	190926956	C	C	190926956	3	2	154	1	0	0	0	0	1	0	0	0	9946	1638	57	5	772	5	MSTN	2	190926956	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	11312877	190926956	52272417	136	27983											
MYO1B	4430	broad.mit.edu	37	chr2	192273886	192273886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	actcacaaggagctaaaaagGattttccacttgtggagggt	13	10	11	7	0	1	0	1	0	0	0	2	3	2	3	1	4	1	1	1	4	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:192273886G>C	uc010fsg.2	+	26	3003	c.2748G>C	c.(2746-2748)AGG>AGC	p.R916S	MYO1B_uc002usq.2_Missense_Mutation_p.R858S|MYO1B_uc002usr.2_Missense_Mutation_p.R916S|MYO1B_uc002usu.2_Missense_Mutation_p.R161S|MYO1B_uc002usv.2_Missense_Mutation_p.R32S	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	916						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			AGCTAAAAAGGATTTTCCACT	0.323													16	74					0	0	0	0	C	192273886	C	C	192273886	3	2	154	1	0	0	0	0	1	0	0	0	10122	1165	41	2	2846	2	MYO1B	2	192273886	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1346930	192273886	50925487	137	27984											
DNAH7	56171	broad.mit.edu	37	chr2	196729351	196729351	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagactgccttccactccctCcaacccctactaggagagca	10	7	6	18	0	0	2	0	0	0	2	3	3	3	2	6	1	4	1	6	1	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:196729351C>T	uc002utj.3	-	41	7129	c.7028G>A	c.(7027-7029)GGA>GAA	p.G2343E		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2343	ATP (Potential).|AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCCACTCCCTCCAACCCCTAC	0.483													4	52					0	0	0	0	T	196729351	T	T	196729351	3	4	154	1	0	0	0	0	1	0	0	0	4628	855	30	2	5146	2	DNAH7	2	196729351	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4455465	196729351	46470022	138	27985											
SATB2	23314	broad.mit.edu	37	chr2	200137230	200137230	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggtctgggtacaggcctaCatcatgaataaagctttgga	11	11	11	8	0	2	1	1	1	1	0	2	2	2	2	1	4	3	2	1	4	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:200137230C>A	uc002uuy.1	-	11	2723	c.1906G>T	c.(1906-1908)GTA>TTA	p.V636L	SATB2_uc010fsq.1_Missense_Mutation_p.V518L|SATB2_uc002uuz.1_Missense_Mutation_p.V636L|SATB2_uc002uva.1_Missense_Mutation_p.V636L	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	636	Homeobox.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TACAGGCCTACATCATGAATA	0.532													13	67					0.00010058	0.000196248	1	0	A	200137230	A	A	200137230	3	1	154	1	0	0	0	0	1	0	0	0	13919	478	17	4	299	4	SATB2	2	200137230	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3407879	200137230	43062143	139	27986											
ALS2CR11	151254	broad.mit.edu	37	chr2	202400908	202400908	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tattgtttcctggttagaaaTagtgcacaatgagtgcactt	11	15	9	6	0	0	2	0	1	0	1	1	2	1	2	1	1	2	4	1	1	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:202400908T>G	uc002uye.2	-	13	1390	c.1342A>C	c.(1342-1344)ATT>CTT	p.I448L	ALS2CR11_uc002uyf.2_Missense_Mutation_p.I448L|ALS2CR11_uc010fti.2_Intron	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	448										large_intestine(1)|ovary(1)|skin(1)	3						TGGTTAGAAATAGTGCACAAT	0.383													21	113					0	0	0	0	G	202400908	G	G	202400908	3	3	154	1	0	0	0	0	1	0	0	0	552	1406	49	5	4283	5	ALS2CR11	2	202400908	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	2263678	202400908	40798465	140	27987											
WDR12	55759	broad.mit.edu	37	chr2	203748374	203748374	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caatgttatctaaagatcctGaaatcagctgctgttcatgg	12	13	8	8	0	3	2	2	1	1	1	4	2	4	2	1	1	2	4	1	1	5	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:203748374G>A	uc002uzl.2	-	11	1829	c.1079C>T	c.(1078-1080)TCA>TTA	p.S360L	WDR12_uc010ftt.2_Missense_Mutation_p.S360L	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	360	WD 6.|Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						TAAAGATCCTGAAATCAGCTG	0.378													6	38					0	0	0	0	A	203748374	A	A	203748374	3	1	154	1	0	0	0	0	1	0	0	0	17342	1294	45	2	204	2	WDR12	2	203748374	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1347466	203748374	39450999	141	27988											
PTH2R	5746	broad.mit.edu	37	chr2	209308194	209308194	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acataggagtaaaggagctgGagtccctaataatgcaggat	15	8	12	6	0	0	0	0	0	0	0	1	4	1	4	1	4	2	3	1	4	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:209308194G>T	uc002vdb.2	+	6	844	c.631G>T	c.(631-633)GAG>TAG	p.E211*	PTH2R_uc010zjb.1_Nonsense_Mutation_p.E222*	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	211	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		AAAGGAGCTGGAGTCCCTAAT	0.398													12	51					4.36969e-10	9.73627e-10	1	0	T	209308194	T	T	209308194	4	4	154	1	0	0	0	0	0	1	0	0	12823	1175	41	2	653	2	PTH2R	2	209308194	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5559820	209308194	33891179	142	27989											
VWC2L	402117	broad.mit.edu	37	chr2	215301378	215301378	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatgtgaatggtgtcgctGtgagcccagcaatgaagttc	9	11	12	9	1	0	3	0	3	0	0	3	3	1	3	2	1	2	3	2	1	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:215301378G>C	uc002vet.2	+	3	546	c.416G>C	c.(415-417)TGT>TCT	p.C139S	VWC2L_uc010zjl.1_Intron	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	139	VWFC 2.					extracellular region					0						TGGTGTCGCTGTGAGCCCAGC	0.448													13	41					0	0	0	0	C	215301378	C	C	215301378	3	2	154	1	0	0	0	0	1	0	0	0	17312	1377	48	4	422	4	VWC2L	2	215301378	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5993184	215301378	27897995	143	27990											
ABCA12	26154	broad.mit.edu	37	chr2	215854053	215854053	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaggaagcacattcatacCtgggaagacattcctgacat	13	10	9	9	0	1	2	1	1	0	1	2	4	2	4	2	2	2	2	2	2	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:215854053C>T	uc002vew.2	-	26	4049	c.3829G>A	c.(3829-3831)GGG>AGG	p.G1277R	ABCA12_uc002vev.2_Missense_Mutation_p.G959R|ABCA12_uc010zjn.1_Missense_Mutation_p.G204R	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1277					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ACATTCATACCTGGGAAGACA	0.328													5	26					0	0	0	0	T	215854053	T	T	215854053	3	4	154	1	0	0	0	0	1	0	0	0	30	695	24	4	4070	4	ABCA12	2	215854053	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	552675	215854053	27345320	144	27991											
PECR	55825	broad.mit.edu	37	chr2	216904001	216904001	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccttgtttcctcagctcaGagcttagctttctccttaaa	8	15	5	13	0	3	1	2	0	1	1	5	1	4	1	3	0	3	4	3	0	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:216904001G>C	uc002vft.2	-	8	977	c.909C>G	c.(907-909)CTC>CTG	p.L303L	PECR_uc010zjq.1_RNA|PECR_uc002vfr.2_Silent_p.L165L|PECR_uc002vfs.2_Silent_p.L157L	NM_018441	NP_060911	Q9BY49	PECR_HUMAN	peroxisomal trans-2-enoyl-CoA reductase	303	Microbody targeting signal.			Missing: Abolishes localization to peroxisomes.	fatty acid biosynthetic process|regulation of apoptosis	peroxisome	binding|trans-2-enoyl-CoA reductase (NADPH) activity				0		Renal(323;0.0327)		Epithelial(149;3.8e-06)|all cancers(144;0.000272)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Adenine(DB00173)	CCTCAGCTCAGAGCTTAGCTT	0.433													19	83					0	0	0	0	C	216904001	C	C	216904001	2	2	154	1	0	0	0	0	0	0	0	1	11771	929	33	2		2	PECR	2	216904001	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1049948	216904001	26295372	145	27992											
CCDC108	255101	broad.mit.edu	37	chr2	219873820	219873820	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcctgccgcaccttctcGtccttccactcctgcagctc	4	12	5	20	2	1	0	0	0	1	0	7	0	5	0	6	0	3	3	6	0	0	3	rs149741043		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:219873820G>A	uc002vjl.1	-	29	4707	c.4623C>T	c.(4621-4623)GAC>GAT	p.D1541D		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	1541	Potential.					integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCACCTTCTCGTCCTTCCACT	0.547													17	57					0	0	0	0	A	219873820	A	A	219873820	2	1	154	1	0	0	0	0	0	0	0	1	2755	1136	40	1		1	CCDC108	2	219873820	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2969819	219873820	23325553	146	27993											
KCNJ13	3769	broad.mit.edu	37	chr2	233635666	233635666	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcatttgtatggcaagtaagGcgattgcacttggacagtca	11	11	12	7	1	1	0	1	0	0	0	1	2	1	1	0	3	1	5	0	3	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:233635666G>A	uc002vto.2	-	1	450	c.407C>T	c.(406-408)GCC>GTC	p.A136V	GIGYF2_uc010zmj.1_Intron|GIGYF2_uc002vtg.2_Intron|GIGYF2_uc002vtj.3_Intron|GIGYF2_uc002vti.3_Intron|GIGYF2_uc002vtk.3_Intron|GIGYF2_uc002vth.3_Intron|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc010zml.1_Intron|KCNJ13_uc002vtn.2_Intron|KCNJ13_uc002vtp.2_Missense_Mutation_p.A136V	NM_002242	NP_002233	O60928	IRK13_HUMAN	potassium inwardly-rectifying channel J13	136	Helical; Name=M2; (By similarity).					voltage-gated potassium channel complex	inward rectifier potassium channel activity				0		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0306)|Lung NSC(271;0.0908)		Epithelial(121;5.9e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0617)		GGCAAGTAAGGCGATTGCACT	0.393													12	50					0	0	0	0	A	233635666	A	A	233635666	3	1	154	1	0	0	0	0	1	0	0	0	8086	1203	42	4	683	4	KCNJ13	2	233635666	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	13761846	233635666	9563707	147	27994											
SPP2	6694	broad.mit.edu	37	chr2	234969088	234969088	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatgctcgctgcagctggTcctcctccacgtctgagtct	4	12	10	15	2	2	1	0	1	2	0	6	1	5	1	3	1	4	5	3	1	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:234969088T>A	uc002vvk.1	+	4	494	c.409T>A	c.(409-411)TCC>ACC	p.S137T	SPP2_uc010fyl.1_Missense_Mutation_p.S57T	NM_006944	NP_008875	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa precursor	137					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity				0		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		CTGCAGCTGGTCCTCCTCCAC	0.562													14	54					0	0	0	0	A	234969088	A	A	234969088	3	1	154	1	0	0	0	0	1	0	0	0	15153	1667	58	5	423	5	SPP2	2	234969088	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1333422	234969088	8230285	148	27995											
KIF1A	547	broad.mit.edu	37	chr2	241727548	241727548	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcacccgtctgcccataggCgaagatgcacacgttgtatc	9	8	11	13	3	1	1	0	0	1	1	2	2	1	1	2	2	2	4	2	2	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:241727548C>T	uc002vzy.2	-	4	429	c.283G>A	c.(283-285)GCC>ACC	p.A95T	KIF1A_uc010fzk.2_Missense_Mutation_p.A95T|KIF1A_uc002vzz.1_Missense_Mutation_p.A95T	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	95	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TGCCCATAGGCGAAGATGCAC	0.617													5	13					0	0	0	0	T	241727548	T	T	241727548	3	4	154	1	0	0	0	0	1	0	0	0	8322	768	27	1	4965	1	KIF1A	2	241727548	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6758460	241727548	1471825	149	27996											
PASK	23178	broad.mit.edu	37	chr2	242054809	242054809	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctccaagaccttctccttcTtaataaacttcaccaccacc	11	11	1	18	0	3	1	1	0	2	1	5	1	4	1	7	0	1	0	7	0	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr2:242054809T>C	uc002wao.1	-	13	3184	c.3092A>G	c.(3091-3093)AAG>AGG	p.K1031R	PASK_uc010zol.1_Missense_Mutation_p.K845R|PASK_uc010zom.1_Missense_Mutation_p.K996R|PASK_uc010fzl.1_Missense_Mutation_p.K1031R|PASK_uc010zon.1_Missense_Mutation_p.K812R|PASK_uc002wap.2_Missense_Mutation_p.K574R|PASK_uc002waq.2_Missense_Mutation_p.K1031R	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	1031	Protein kinase.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CTTCTCCTTCTTAATAAACTT	0.493													15	48					0	0	0	0	C	242054809	C	C	242054809	3	2	154	1	0	0	0	0	1	0	0	0	11526	1609	56	5	903	5	PASK	2	242054809	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	327261	242054809	1144564	150	27997											
ITPR1	3708	broad.mit.edu	37	chr3	4847887	4847887	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgttgagttcctctatcAtttgttgtatctggtgatct	6	19	10	6	0	4	2	1	2	3	0	5	3	5	3	1	2	0	4	1	2	2	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:4847887A>G	uc003bqa.2	+	52	7412	c.7064A>G	c.(7063-7065)CAT>CGT	p.H2355R	ITPR1_uc010hca.1_Missense_Mutation_p.H2340R|ITPR1_uc011asu.1_Missense_Mutation_p.H366R|ITPR1_uc003bqc.2_Missense_Mutation_p.H1325R|ITPR1_uc010hcc.1_Missense_Mutation_p.H123R|ITPR1_uc011asv.1_Missense_Mutation_p.H79R	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2403	Lumenal (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TTCCTCTATCATTTGTTGTAT	0.443													22	35					0	0	0	0	G	4847887	G	G	4847887	3	3	154	1	0	0	0	0	1	0	0	0	7959	217	8	5	7418	5	ITPR1	3	4847887	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08		4847887	193174543	151	27998											
OGG1	4968	broad.mit.edu	37	chr3	9796474	9796474	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcccgagccatcctggaaGaacagggcgggctagcctgg	8	5	16	12	2	0	1	0	0	0	1	1	3	1	2	4	4	4	1	4	4	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:9796474G>C	uc003bsi.2	+	4	995	c.652G>C	c.(652-654)GAA>CAA	p.E218Q	OGG1_uc003bsh.2_Missense_Mutation_p.E218Q|OGG1_uc003bsj.2_Missense_Mutation_p.E218Q|OGG1_uc003bsk.2_Missense_Mutation_p.E218Q|OGG1_uc003bsl.2_Missense_Mutation_p.E218Q|OGG1_uc003bsm.2_Missense_Mutation_p.E218Q|OGG1_uc003bsn.2_Missense_Mutation_p.E218Q|OGG1_uc003bso.2_Intron|OGG1_uc003bsp.1_Intron|OGG1_uc010hcm.1_Missense_Mutation_p.E61Q|OGG1_uc003bsq.1_Intron|OGG1_uc003bsr.1_Intron	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	218					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)					CATCCTGGAAGAACAGGGCGG	0.642								BER_DNA_glycosylases					5	16					0	0	0	0	C	9796474	C	C	9796474	3	2	154	1	0	0	0	0	1	0	0	0	10899	943	33	2	666	2	OGG1	3	9796474	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4948587	9796474	188225956	152	27999											
MYRIP	25924	broad.mit.edu	37	chr3	40231679	40231679	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctccgcaggctcttccCgagaagttgggcaccaggcc	6	7	11	17	2	1	1	0	0	1	1	4	2	4	1	6	3	0	4	6	3	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:40231679C>A	uc003cka.2	+	10	1525	c.1390C>A	c.(1390-1392)CGA>AGA	p.R464R	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.R464R|MYRIP_uc010hhw.2_Silent_p.R375R|MYRIP_uc011ayz.1_Silent_p.R277R|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	464	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		AGGCTCTTCCCGAGAAGTTGG	0.622													15	42					0.000308642	0.000596256	1	0	A	40231679	A	A	40231679	2	1	154	1	0	0	0	0	0	0	0	1	10153	644	23	3		3	MYRIP	3	40231679	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	30435205	40231679	157790751	153	28000											
CCDC13	152206	broad.mit.edu	37	chr3	42793455	42793455	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtctcccatctgggccctCggtggcttggctcctgcgtc	1	12	12	16	2	2	0	0	0	2	0	6	0	3	0	3	4	1	2	3	4	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:42793455C>T	uc003cly.3	-	5	660	c.576G>A	c.(574-576)CCG>CCA	p.P192P	CCDC13_uc003clz.2_Silent_p.P192P|CCDC13_uc011azq.1_Silent_p.P192P	NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	192	Potential.									ovary(1)	1						TCTGGGCCCTCGGTGGCTTGG	0.597													21	49					0	0	0	0	T	42793455	T	T	42793455	2	4	154	1	0	0	0	0	0	0	0	1	2777	871	31	1		1	CCDC13	3	42793455	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2561776	42793455	155228975	154	28001											
ZNF445	353274	broad.mit.edu	37	chr3	44489577	44489577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtgaattttctcatgccgcGcacagttggaactccaccgg	8	11	10	12	3	1	1	1	1	1	0	3	2	2	2	3	2	2	2	3	2	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:44489577G>A	uc003cnf.2	-	8	1934	c.1586C>T	c.(1585-1587)GCG>GTG	p.A529V	ZNF445_uc011azv.1_Missense_Mutation_p.A517V|ZNF445_uc011azw.1_Missense_Mutation_p.A529V	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	529	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		CTCATGCCGCGCACAGTTGGA	0.483													9	73					0	0	0	0	A	44489577	A	A	44489577	3	1	154	1	0	0	0	0	1	0	0	0	17985	1087	38	1	1513	1	ZNF445	3	44489577	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1696122	44489577	153532853	155	28002											
DNAH1	25981	broad.mit.edu	37	chr3	52404172	52404172	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgaaggaggtgatcgcctCaaccaactgcaacctgacca	13	6	10	12	1	1	3	1	3	0	0	2	4	1	4	4	2	4	1	4	2	4	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:52404172C>T	uc011bef.1	+	39	6446	c.6185C>T	c.(6184-6186)TCA>TTA	p.S2062L		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2062					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTGATCGCCTCAACCAACTGC	0.577													4	30					0	0	0	0	T	52404172	T	T	52404172	3	4	154	1	0	0	0	0	1	0	0	0	4619	838	29	2	6335	2	DNAH1	3	52404172	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	7914595	52404172	145618258	156	28003											
ITIH4	3700	broad.mit.edu	37	chr3	52852070	52852070	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtgtgcctctctcacctTgctcagggtctgagagcagg	5	11	14	11	0	4	1	2	1	2	1	5	2	4	1	2	3	3	2	2	3	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:52852070T>C	uc003dfz.2	-	20	2330	c.2294A>G	c.(2293-2295)CAA>CGA	p.Q765R	ITIH4_uc011bel.1_Missense_Mutation_p.Q479R|ITIH4_uc003dfy.2_Intron|ITIH4_uc011bem.1_Missense_Mutation_p.Q770R|ITIH4_uc011ben.1_Missense_Mutation_p.Q735R	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	765					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		TCTCTCACCTTGCTCAGGGTC	0.647													13	27					0	0	0	0	C	52852070	C	C	52852070	3	2	154	1	0	0	0	0	1	0	0	0	7945	1812	63	5	518	5	ITIH4	3	52852070	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	447898	52852070	145170360	157	28004											
CNTN3	5067	broad.mit.edu	37	chr3	74350577	74350577	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagttcttactttttctgaGggtaaacttggttctccacc	7	17	7	10	0	4	1	1	1	3	0	5	1	4	1	2	2	2	3	2	2	3	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:74350577G>A	uc003dpm.1	-	15	2147	c.2067C>T	c.(2065-2067)CCC>CCT	p.P689P		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	689	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CTTTTTCTGAGGGTAAACTTG	0.413													14	61					0	0	0	0	A	74350577	A	A	74350577	2	1	154	1	0	0	0	0	0	0	0	1	3657	987	35	4		4	CNTN3	3	74350577	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	21498507	74350577	123671853	158	28005											
VGLL3	389136	broad.mit.edu	37	chr3	87018032	87018032	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatggctgtaggatgggctCacctgagatgtcaaaggata	12	10	13	6	0	2	1	2	1	0	1	2	4	2	3	1	4	0	3	1	4	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:87018032C>A	uc003dqn.2	-	3	1009	c.645G>T	c.(643-645)GTG>GTT	p.V215V		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	215					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		AGGATGGGCTCACCTGAGATG	0.483													17	34					7.07596e-05	0.000139301	1	0	A	87018032	A	A	87018032	2	1	154	1	0	0	0	0	0	0	0	1	17228	813	29	2		2	VGLL3	3	87018032	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	12667455	87018032	111004398	159	28006											
OR5H1	26341	broad.mit.edu	37	chr3	97851900	97851900	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctcttggcaacgatggcatAtgatcgctatgtagccatat	10	13	9	9	2	1	1	0	1	1	0	3	2	1	1	1	2	2	4	1	2	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:97851900A>G	uc011bgt.1	+	1	359	c.359A>G	c.(358-360)TAT>TGT	p.Y120C		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						ACGATGGCATATGATCGCTAT	0.393													4	183					0	0	0	0	G	97851900	G	G	97851900	3	3	154	1	0	0	0	0	1	0	0	0	11213	449	16	5	361	5	OR5H1	3	97851900	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	10833868	97851900	100170530	160	28007			1	43		3	3	468	N	C_A	7.88813e-05
OR5H1	26341	broad.mit.edu	37	chr3	97852332	97852332	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catttatgtgggccctgcatCtccgcaagcagatgatcaag	10	10	10	11	1	2	2	1	1	1	1	3	2	2	2	2	1	2	3	2	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:97852332C>G	uc011bgt.1	+	1	791	c.791C>G	c.(790-792)TCT>TGT	p.S264C		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GGCCCTGCATCTCCGCAAGCA	0.433													13	110					0	0	0	0	G	97852332	G	G	97852332	3	3	154	1	0	0	0	0	1	0	0	0	11213	913	32	2	793	2	OR5H1	3	97852332	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	432	97852332	100170098	161	28008			1	43		3	3	468	N	C_A	7.88813e-05
OR5H1	26341	broad.mit.edu	37	chr3	97852367	97852367	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaagatatggtggagcctCtattctacactgtcatcatt	11	14	7	9	0	5	1	3	0	2	1	5	2	5	2	1	2	2	0	1	2	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:97852367C>G	uc011bgt.1	+	1	826	c.826C>G	c.(826-828)CTA>GTA	p.L276V		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GGTGGAGCCTCTATTCTACAC	0.393													13	101					0	0	0	0	G	97852367	G	G	97852367	3	3	154	1	0	0	0	0	1	0	0	0	11213	912	32	2	828	2	OR5H1	3	97852367	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	35	97852367	100170063	162	28009			1	43		3	3	468	N	C_A	7.88813e-05
MYH15	22989	broad.mit.edu	37	chr3	108135752	108135752	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtttatcagagcctccttCtcttcaagcctccgtaggaa	8	13	8	12	1	3	1	2	0	1	1	6	2	5	2	4	2	2	2	4	2	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:108135752C>G	uc003dxa.1	-	30	3972	c.3915G>C	c.(3913-3915)GAG>GAC	p.E1305D		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1305	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GAGCCTCCTTCTCTTCAAGCC	0.438													8	61					0	0	0	0	G	108135752	G	G	108135752	3	3	154	1	0	0	0	0	1	0	0	0	10087	912	32	2	1977	2	MYH15	3	108135752	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	10283385	108135752	89886678	163	28010											
CD200R1	131450	broad.mit.edu	37	chr3	112648042	112648042	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgatgctccttacctaacActtggaggtgatatccacga	11	12	8	10	1	0	2	0	2	0	0	2	4	2	3	3	2	3	1	3	2	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:112648042A>C	uc003dzk.1	-	3	679	c.446T>G	c.(445-447)GTG>GGG	p.V149G	CD200R1_uc003dzj.1_Missense_Mutation_p.V172G|CD200R1_uc011bhx.1_Missense_Mutation_p.V127G|CD200R1_uc003dzl.1_Missense_Mutation_p.V172G|CD200R1_uc003dzm.1_Missense_Mutation_p.V149G	NM_170780	NP_740750	Q8TD46	MO2R1_HUMAN	CD200 receptor 1 isoform d	149	Ig-like C2-type.|Extracellular (Potential).				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(2)|pancreas(1)	3						CTTACCTAACACTTGGAGGTG	0.418													8	93					0	0	0	0	C	112648042	C	C	112648042	3	2	154	1	0	0	0	0	1	0	0	0	2996	159	6	5	598	5	CD200R1	3	112648042	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	4512290	112648042	85374388	164	28011											
WDR52	55779	broad.mit.edu	37	chr3	113085109	113085109	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgatttaggacatagactCgaattgctccatttttcatt	10	18	6	7	1	1	2	1	1	0	1	3	4	2	3	1	1	1	1	1	1	3	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:113085109C>A	uc003eae.1	-	19	2538	c.2492G>T	c.(2491-2493)CGA>CTA	p.R831L	WDR52_uc003ead.1_Missense_Mutation_p.R12L	NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	831	WD 8.									central_nervous_system(1)	1						GACATAGACTCGAATTGCTCC	0.308													10	30					0.000442599	0.000850371	1	0	A	113085109	A	A	113085109	3	1	154	1	0	0	0	0	1	0	0	0	17372	884	31	3	3155	3	WDR52	3	113085109	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	437067	113085109	84937321	165	28012											
TMEM39A	55254	broad.mit.edu	37	chr3	119156656	119156656	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taggcactgaagagggagttGaagagaacctccttgattct	12	10	12	7	0	1	5	0	3	1	2	2	7	2	6	2	2	1	2	2	2	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:119156656G>A	uc003eck.1	-	6	1233	c.870C>T	c.(868-870)TTC>TTT	p.F290F	TMEM39A_uc003ecl.1_Silent_p.F138F	NM_018266	NP_060736	Q9NV64	TM39A_HUMAN	transmembrane protein 39A	290	Helical; (Potential).					integral to membrane				ovary(1)|breast(1)	2				GBM - Glioblastoma multiforme(114;0.244)		AGAGGGAGTTGAAGAGAACCT	0.448													7	37					0	0	0	0	A	119156656	A	A	119156656	2	1	154	1	0	0	0	0	0	0	0	1	16227	1281	45	2		2	TMEM39A	3	119156656	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	6071547	119156656	78865774	166	28013											
ADPRH	141	broad.mit.edu	37	chr3	119306495	119306495	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatgattgcctacgatgctGttcttgctgcaggagactcc	7	12	10	12	1	1	2	0	1	1	1	2	4	2	2	3	1	5	4	3	1	1	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:119306495G>T	uc003ecs.2	+	5	1142	c.844G>T	c.(844-846)GTT>TTT	p.V282F	ADPRH_uc010hqv.2_Missense_Mutation_p.V282F|ADPRH_uc011bjb.1_Missense_Mutation_p.V175F|ADPRH_uc003ect.2_Missense_Mutation_p.V282F	NM_001125	NP_001116	P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	282					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			ovary(1)	1		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		CTACGATGCTGTTCTTGCTGC	0.577													16	50					4.7546e-09	1.03448e-08	1	0	T	119306495	T	T	119306495	3	4	154	1	0	0	0	0	1	0	0	0	331	1377	48	4	854	4	ADPRH	3	119306495	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	149839	119306495	78715935	167	28014											
STXBP5L	9515	broad.mit.edu	37	chr3	120998664	120998664	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctcttagagttgcatttggGaactgcaatgggttggctgt	7	15	13	6	0	1	1	0	0	1	1	2	2	1	2	0	3	3	5	0	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:120998664G>T	uc003eec.3	+	19	2111	c.1971G>T	c.(1969-1971)GGG>GGT	p.G657G	STXBP5L_uc011bji.1_Silent_p.G657G	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	657	WD 10.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		TTGCATTTGGGAACTGCAATG	0.353													11	75					2.80697e-09	6.14528e-09	1	0	T	120998664	T	T	120998664	2	4	154	1	0	0	0	0	0	0	0	1	15423	1161	41	2		2	STXBP5L	3	120998664	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1692169	120998664	77023766	168	28015											
POLQ	10721	broad.mit.edu	37	chr3	121217352	121217352	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggccatttgtcgatgctGtctctcagttctggctacta	6	15	10	10	1	3	0	1	0	2	0	5	2	3	0	1	2	2	3	1	2	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:121217352G>A	uc003eee.3	-	13	2254	c.2125C>T	c.(2125-2127)CAG>TAG	p.Q709*		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	709					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TGTCGATGCTGTCTCTCAGTT	0.388								DNA_polymerases_(catalytic_subunits)					7	131					0	0	0	0	A	121217352	A	A	121217352	4	1	154	1	0	0	0	0	0	1	0	0	12263	1386	48	4	5719	4	POLQ	3	121217352	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	218688	121217352	76805078	169	28016											
PARP14	54625	broad.mit.edu	37	chr3	122437543	122437543	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgaaattgaggcgatgatCaagagagttcgattggccaa	14	9	13	5	2	1	4	1	3	0	1	2	8	1	4	1	2	0	1	1	2	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:122437543C>G	uc003efq.3	+	14	4604	c.4545C>G	c.(4543-4545)ATC>ATG	p.I1515M	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.I1232M|PARP14_uc003efs.1_Missense_Mutation_p.I1232M	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		AGGCGATGATCAAGAGAGTTC	0.383													21	229					0	0	0	0	G	122437543	G	G	122437543	3	3	154	1	0	0	0	0	1	0	0	0	11512	816	29	2	4599	2	PARP14	3	122437543	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1220191	122437543	75584887	170	28017											
PDIA5	10954	broad.mit.edu	37	chr3	122811251	122811251	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtccacagtggcccaggcGgtgaaaggacaagggaccat	11	5	14	11	1	0	1	0	1	0	0	1	3	1	3	3	5	0	0	3	5	2	0	rs139086659	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:122811251G>T	uc003egc.1	+	3	275	c.219G>T	c.(217-219)GCG>GCT	p.A73A	PDIA5_uc003egd.1_RNA	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	73					cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		TGGCCCAGGCGGTGAAAGGAC	0.527													12	52					0.00010058	0.000196248	1	0	T	122811251	T	T	122811251	2	4	154	1	0	0	0	0	0	0	0	1	11725	1103	39	3		3	PDIA5	3	122811251	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	373708	122811251	75211179	171	28018											
PDIA5	10954	broad.mit.edu	37	chr3	122842957	122842957	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctctgaatttgaaaacatCaaggaggagtacagcgtgcg	13	9	11	8	2	2	2	1	2	1	0	3	4	3	4	1	2	4	1	1	2	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:122842957C>T	uc003egc.1	+	9	710	c.654C>T	c.(652-654)ATC>ATT	p.I218I	PDIA5_uc003egd.1_RNA	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	218	Thioredoxin 1.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		TTGAAAACATCAAGGAGGAGT	0.557													17	62					0	0	0	0	T	122842957	T	T	122842957	2	4	154	1	0	0	0	0	0	0	0	1	11725	816	29	2		2	PDIA5	3	122842957	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	31706	122842957	75179473	172	28019											
ALDH1L1	10840	broad.mit.edu	37	chr3	125879705	125879705	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctcactcacccagggggtCggcctttccatccttgtctg	4	11	11	15	1	3	0	2	0	1	0	6	0	5	0	4	4	0	1	4	4	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:125879705C>A	uc003eim.1	-	2	308	c.118G>T	c.(118-120)GAC>TAC	p.D40Y	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.D40Y|ALDH1L1_uc010hsf.1_Silent_p.P4P|ALDH1L1_uc003eip.1_5'Flank|ALDH1L1_uc011bkj.1_5'UTR	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	40	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CCCAGGGGGTCGGCCTTTCCA	0.597													18	102					1.01871e-10	2.28722e-10	1	0	A	125879705	A	A	125879705	3	1	154	1	0	0	0	0	1	0	0	0	494	884	31	3	2678	3	ALDH1L1	3	125879705	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3036748	125879705	72142725	173	28020											
ABTB1	80325	broad.mit.edu	37	chr3	127395201	127395201	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgctgcgtcctgggtgcacGtagtgcctactttgccaaca	6	11	11	13	3	0	0	0	0	0	0	2	0	1	0	3	1	6	3	3	1	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:127395201G>A	uc003ejt.2	+	5	495	c.407G>A	c.(406-408)CGT>CAT	p.R136H	ABTB1_uc003ejr.2_5'UTR|ABTB1_uc003ejs.2_Missense_Mutation_p.R111H|ABTB1_uc003eju.2_5'UTR|ABTB1_uc010hsm.2_5'Flank	NM_172027	NP_742024	Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	136	BTB 1.					cytoplasm|nucleolus|plasma membrane	translation elongation factor activity				0						CTGGGTGCACGTAGTGCCTAC	0.582													7	125					0	0	0	0	A	127395201	A	A	127395201	3	1	154	1	0	0	0	0	1	0	0	0	102	1145	40	1	425	1	ABTB1	3	127395201	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1515496	127395201	70627229	174	28021											
ATP2C1	27032	broad.mit.edu	37	chr3	130649306	130649306	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtgaaaatgagacaatgaTtcctgtattgacatcaaaaa	17	11	8	5	0	1	4	1	4	0	1	2	5	2	4	1	1	0	1	1	1	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:130649306T>A	uc003enl.2	+	3	275	c.53T>A	c.(52-54)ATT>AAT	p.I18N	ATP2C1_uc011blg.1_Missense_Mutation_p.I52N|ATP2C1_uc011blh.1_Missense_Mutation_p.I52N|ATP2C1_uc011bli.1_Missense_Mutation_p.I52N|ATP2C1_uc003enk.2_Missense_Mutation_p.I2N|ATP2C1_uc003enm.2_Missense_Mutation_p.I18N|ATP2C1_uc003enn.2_Missense_Mutation_p.I2N|ATP2C1_uc003eno.2_Missense_Mutation_p.I18N|ATP2C1_uc003enp.2_Missense_Mutation_p.I18N|ATP2C1_uc003enq.2_Missense_Mutation_p.I18N|ATP2C1_uc003enr.2_Missense_Mutation_p.I18N|ATP2C1_uc003ens.2_Missense_Mutation_p.I18N|ATP2C1_uc003ent.2_Missense_Mutation_p.I18N	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	18	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	GAGACAATGATTCCTGTATTG	0.363									Hailey-Hailey_disease				7	36					0	0	0	0	A	130649306	A	A	130649306	3	1	154	1	0	0	0	0	1	0	0	0	1145	1493	52	5	59	5	ATP2C1	3	130649306	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	3254105	130649306	67373124	175	28022											
CCRL1	51554	broad.mit.edu	37	chr3	132320167	132320167	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatgtttttatgggagcatCtttcaaaaactacgttatga	12	17	7	5	1	2	1	1	1	1	0	2	2	2	2	0	1	3	3	0	1	6	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:132320167C>G	uc003eow.2	+	2	1009	c.926C>G	c.(925-927)TCT>TGT	p.S309C	ACAD11_uc003eov.3_Intron|ACAD11_uc011blr.1_Intron|CCRL1_uc003eox.2_Missense_Mutation_p.S309C	NM_016557	NP_057641	Q9NPB9	CCRL1_HUMAN	chemokine (C-C motif) receptor-like 1	309	Helical; Name=7; (Potential).				chemotaxis|immune response	integral to plasma membrane	C-C chemokine receptor activity				0						ATGGGAGCATCTTTCAAAAAC	0.443													7	93					0	0	0	0	G	132320167	G	G	132320167	3	3	154	1	0	0	0	0	1	0	0	0	2964	913	32	2	928	2	CCRL1	3	132320167	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1670861	132320167	65702263	176	28023											
DZIP1L	199221	broad.mit.edu	37	chr3	137803006	137803006	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgttcctgcagctgggcacgGagggtgctgatctggcactg	5	10	16	10	1	1	1	0	1	1	0	2	2	2	2	1	4	3	6	1	4	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:137803006G>C	uc003erq.2	-	8	1515	c.1152C>G	c.(1150-1152)CTC>CTG	p.L384L	DZIP1L_uc003err.1_Silent_p.L384L	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	384	Potential.					intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						GCTGGGCACGGAGGGTGCTGA	0.612													5	91					0	0	0	0	C	137803006	C	C	137803006	2	2	154	1	0	0	0	0	0	0	0	1	4886	1161	41	2		2	DZIP1L	3	137803006	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5482839	137803006	60219424	177	28024											
COPB2	9276	broad.mit.edu	37	chr3	139090585	139090585	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgaagaatcgtgggcccaTgcaaactcctgagcagatcc	11	8	10	12	1	1	4	0	2	1	2	4	4	3	4	3	1	3	2	3	1	3	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:139090585T>C	uc003etf.3	-	10	1315	c.1185A>G	c.(1183-1185)GCA>GCG	p.A395A	COPB2_uc011bmv.1_Silent_p.A366A|COPB2_uc010hui.2_Silent_p.A366A	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	395	WD 8.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						CGTGGGCCCATGCAAACTCCT	0.453													7	102					0	0	0	0	C	139090585	C	C	139090585	2	2	154	1	0	0	0	0	0	0	0	1	3744	1451	51	5		5	COPB2	3	139090585	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1287579	139090585	58931845	178	28025											
TRIM42	287015	broad.mit.edu	37	chr3	140397246	140397246	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgccactgcacctgttctGagagccccaactgccattgg	7	10	9	15	0	2	1	0	1	2	1	2	2	2	1	5	1	5	2	5	1	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:140397246G>C	uc003eto.1	+	1	366	c.175G>C	c.(175-177)GAG>CAG	p.E59Q		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	59	Cys-rich.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CACCTGTTCTGAGAGCCCCAA	0.537													7	105					0	0	0	0	C	140397246	C	C	140397246	3	2	154	1	0	0	0	0	1	0	0	0	16584	1291	45	2	177	2	TRIM42	3	140397246	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1306661	140397246	57625184	179	28026											
ATR	545	broad.mit.edu	37	chr3	142224127	142224127	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccactccatcaggttcatGcatagcagcatacaatttct	11	11	7	12	0	3	0	2	0	1	0	4	0	4	0	2	2	4	4	2	2	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:142224127G>C	uc003eux.3	-	29	5172	c.5050C>G	c.(5050-5052)CAT>GAT	p.H1684D		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1684	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TCAGGTTCATGCATAGCAGCA	0.363								Other_conserved_DNA_damage_response_genes					16	215					0	0	0	0	C	142224127	C	C	142224127	3	2	154	1	0	0	0	0	1	0	0	0	1206	1319	46	4	2960	4	ATR	3	142224127	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1826881	142224127	55798303	180	28027											
ZIC4	84107	broad.mit.edu	37	chr3	147113922	147113922	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcggggtcgcggtgccgtcGgccgccagccacttgcagat	4	7	15	15	6	0	1	0	0	0	1	3	1	0	1	4	4	3	1	4	4	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:147113922G>C	uc003ewd.1	-	3	678	c.405C>G	c.(403-405)GCC>GCG	p.A135A	ZIC4_uc003ewc.1_Silent_p.A65A|ZIC4_uc011bno.1_Silent_p.A185A	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	135	C2H2-type 1; atypical.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						CGGTGCCGTCGGCCGCCAGCC	0.657													12	53					0	0	0	0	C	147113922	C	C	147113922	2	2	154	1	0	0	0	0	0	0	0	1	17748	1103	39	3		3	ZIC4	3	147113922	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4889795	147113922	50908508	181	28028											
FAM194A	131831	broad.mit.edu	37	chr3	150421607	150421607	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcttcctcctcctcctcctCctctaactcctcctctgact	3	15	1	22	0	3	1	0	1	3	0	11	1	11	1	8	0	1	0	8	0	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:150421607C>T	uc003eyg.2	-	1	136	c.79G>A	c.(79-81)GAG>AAG	p.E27K	FAM194A_uc003eyh.2_5'UTR	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	27	Glu-rich.									skin(2)|ovary(1)	3						tcctcctcctcctctaactcc	0.279													8	34					0	0	0	0	T	150421607	T	T	150421607	3	4	154	1	0	0	0	0	1	0	0	0	5554	864	30	2	1968	2	FAM194A	3	150421607	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3307685	150421607	47600823	182	28029											
SIAH2	6478	broad.mit.edu	37	chr3	150460112	150460112	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttcccattcaactccagtCtgtaggcaaagttctcggct	8	12	9	12	1	3	0	1	0	2	0	6	0	5	0	2	3	1	5	2	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:150460112C>G	uc003eyi.2	-	2	1418	c.791G>C	c.(790-792)AGA>ACA	p.R264T		NM_005067	NP_005058	O43255	SIAH2_HUMAN	seven in absentia homolog 2	264	SBD.				apoptosis|axon guidance|cell cycle|negative regulation of canonical Wnt receptor signaling pathway|small GTPase mediated signal transduction|ubiquitin-dependent protein catabolic process	cytosol|nucleus	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CAACTCCAGTCTGTAGGCAAA	0.567													4	66					0	0	0	0	G	150460112	G	G	150460112	3	3	154	1	0	0	0	0	1	0	0	0	14365	913	32	2	187	2	SIAH2	3	150460112	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	38505	150460112	47562318	183	28030											
MED12L	116931	broad.mit.edu	37	chr3	151073819	151073819	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcaacggactaattgacttcGcaatacaggtgtcaaagaga	15	9	9	8	2	2	2	2	1	0	1	3	4	2	3	0	2	2	1	0	2	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:151073819G>A	uc003eyp.2	+	17	2586	c.2548G>A	c.(2548-2550)GCA>ACA	p.A850T	MED12L_uc011bnz.1_Missense_Mutation_p.A710T|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.A14T	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	850					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AATTGACTTCGCAATACAGGT	0.403													19	56					0	0	0	0	A	151073819	A	A	151073819	3	1	154	1	0	0	0	0	1	0	0	0	9482	1087	38	1	2614	1	MED12L	3	151073819	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	613707	151073819	46948611	184	28031											
LEKR1	389170	broad.mit.edu	37	chr3	156711004	156711004	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccttgcagaaaatgaactGgagataaccaaaactcttct	17	9	6	9	0	2	3	0	1	2	2	2	4	2	3	2	1	5	1	2	1	7	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:156711004G>T	uc003fba.1	+	10	1470	c.135G>T	c.(133-135)CTG>CTT	p.L45L		NM_001004316	NP_001004316	Q6ZMV7	LEKR1_HUMAN	leucine, glutamate and lysine rich 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AAAATGAACTGGAGATAACCA	0.328													21	88					4.26978e-12	9.78653e-12	1	0	T	156711004	T	T	156711004	2	4	154	1	0	0	0	0	0	0	0	1	8757	1335	47	4		4	LEKR1	3	156711004	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5637185	156711004	41311426	185	28032											
GFM1	85476	broad.mit.edu	37	chr3	158399882	158399882	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagaggactacactaaatTggaattttcagatgaaacat	16	10	7	8	0	1	3	1	1	0	2	1	5	1	5	1	2	2	0	1	2	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:158399882T>A	uc003fce.2	+	14	1807	c.1700T>A	c.(1699-1701)TTG>TAG	p.L567*	GFM1_uc003fcd.2_Nonsense_Mutation_p.L567*|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Nonsense_Mutation_p.L498*	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	567					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TACACTAAATTGGAATTTTCA	0.368													5	25					0	0	0	0	A	158399882	A	A	158399882	4	1	154	1	0	0	0	0	0	1	0	0	6378	1821	63	5	1754	5	GFM1	3	158399882	Nonsense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1688878	158399882	39622548	186	28033											
KPNA4	3840	broad.mit.edu	37	chr3	160243624	160243624	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaattaaaacacaaagggcTggaagaatctgaggagagaa	19	6	12	4	0	1	4	0	2	1	2	1	7	1	6	0	3	1	1	0	3	7	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:160243624T>A	uc003fdn.2	-	10	1041	c.735A>T	c.(733-735)CCA>CCT	p.P245P		NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4	245	ARM 5.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			CACAAAGGGCTGGAAGAATCT	0.244													4	19					0	0	0	0	A	160243624	A	A	160243624	2	1	154	1	0	0	0	0	0	0	0	1	8471	1567	55	5		5	KPNA4	3	160243624	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1843742	160243624	37778806	187	28034											
GOLIM4	27333	broad.mit.edu	37	chr3	167750532	167750532	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttcttgttggattggctctgGgggagcctgaaattctgcct	5	15	13	8	0	3	1	0	1	3	0	3	3	3	3	2	4	2	2	2	4	1	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:167750532G>A	uc003ffe.2	-	9	1296	c.952C>T	c.(952-954)CCA>TCA	p.P318S	GOLIM4_uc011bpe.1_Missense_Mutation_p.P318S|GOLIM4_uc011bpf.1_Missense_Mutation_p.P290S|GOLIM4_uc011bpg.1_Missense_Mutation_p.P290S	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	318	Glu-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						ATTGGCTCTGGGGGAGCCTGA	0.507													58	101					0	0	0	0	A	167750532	A	A	167750532	3	1	154	1	0	0	0	0	1	0	0	0	6603	1232	43	4	1170	4	GOLIM4	3	167750532	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	7506908	167750532	30271898	188	28035											
FNDC3B	64778	broad.mit.edu	37	chr3	172025215	172025215	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgttagcttcaccacccAcagctgtgcacccgagtgtc	7	9	9	16	1	1	0	1	0	0	0	2	1	1	0	4	0	3	4	4	0	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:172025215A>T	uc003fhy.2	+	10	1296	c.1124A>T	c.(1123-1125)CAC>CTC	p.H375L	FNDC3B_uc003fhz.3_Missense_Mutation_p.H375L|FNDC3B_uc003fia.2_Missense_Mutation_p.H306L	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	375						endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TTCACCACCCACAGCTGTGCA	0.512													23	80					0	0	0	0	T	172025215	T	T	172025215	3	4	154	1	0	0	0	0	1	0	0	0	6002	159	6	5	1158	5	FNDC3B	3	172025215	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	4274683	172025215	25997215	189	28036											
NLGN1	22871	broad.mit.edu	37	chr3	173322659	173322659	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catatgcagccccaccaacaGgggaacgtcgttttcagcct	10	8	9	14	2	1	0	1	0	0	0	2	1	1	1	4	2	5	2	4	2	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:173322659G>T	uc003fio.1	+	3	694	c.271G>T	c.(271-273)GGG>TGG	p.G91W	NLGN1_uc010hww.1_Missense_Mutation_p.G91W|NLGN1_uc003fip.1_Missense_Mutation_p.G91W	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	91	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CCCACCAACAGGGGAACGTCG	0.448													62	136					1.07796e-43	2.69183e-43	1	0	T	173322659	T	T	173322659	3	4	154	1	0	0	0	0	1	0	0	0	10515	1000	35	4	273	4	NLGN1	3	173322659	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1297444	173322659	24699771	190	28037											
NLGN1	22871	broad.mit.edu	37	chr3	173998723	173998723	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcagccctgtactacaaaaAggataagaggagacatgatg	16	7	11	7	0	0	3	0	1	0	2	0	5	0	4	1	2	4	2	1	2	5	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:173998723A>C	uc003fio.1	+	7	2525	c.2102A>C	c.(2101-2103)AAG>ACG	p.K701T	NLGN1_uc003fip.1_Missense_Mutation_p.K701T	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	718	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TACTACAAAAAGGATAAGAGG	0.468													20	78					0	0	0	0	C	173998723	C	C	173998723	3	2	154	1	0	0	0	0	1	0	0	0	10515	72	3	5	2120	5	NLGN1	3	173998723	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	676064	173998723	24023707	191	28038											
NLGN1	22871	broad.mit.edu	37	chr3	173999063	173999063	+	Frame_Shift_Del	DEL	C	-	-																															ctgccccatccccatccccaCccccattcacattcaacaac																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:173999063delC	uc003fio.1	+	7	2865	c.2442delC	c.(2440-2442)CACfs	p.H814fs	NLGN1_uc003fip.1_Frame_Shift_Del_p.H814fs	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	831	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CCCATCCCCACCCCCATTCAC	0.418													---	---	---								-	173999063	-	-	173999063	7	5	154	1	0	1	0	1	0	0	0	0	10515	506	18	0	2460	0	NLGN1	3	173999063	Frame_Shift_Del	DEL	C	TCGA-CR-7388-01A-11D-2012-08	340	173999063	24023367	192	28039											
MCF2L2	23101	broad.mit.edu	37	chr3	182937691	182937691	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtctatctccatatcttcagGagactcgaaatccagcagac	12	10	7	12	1	4	2	1	0	3	2	7	4	5	2	2	1	1	1	2	1	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:182937691G>C	uc003fli.1	-	21	2413	c.2323C>G	c.(2323-2325)CCT>GCT	p.P775A		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	775	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ATATCTTCAGGAGACTCGAAA	0.348													12	188					0	0	0	0	C	182937691	C	C	182937691	3	2	154	1	0	0	0	0	1	0	0	0	9433	1174	41	2	1061	2	MCF2L2	3	182937691	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	8938628	182937691	15084739	193	28040											
MCF2L2	23101	broad.mit.edu	37	chr3	183028720	183028720	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccttacaaaaatcgtgctCaaaatgctgtagttgtaggc	13	12	8	8	1	1	0	1	0	0	0	2	0	1	0	1	1	4	5	1	1	8	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:183028720C>G	uc003fli.1	-	9	1066	c.976G>C	c.(976-978)GAG>CAG	p.E326Q	MCF2L2_uc003flj.1_Missense_Mutation_p.E326Q|MCF2L2_uc003flp.1_Missense_Mutation_p.E361Q|MCF2L2_uc011bqs.1_RNA	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	326	Spectrin.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			AAATCGTGCTCAAAATGCTGT	0.403													3	77					0	0	0	0	G	183028720	G	G	183028720	3	3	154	1	0	0	0	0	1	0	0	0	9433	835	29	2	2456	2	MCF2L2	3	183028720	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	91029	183028720	14993710	194	28041											
ABCF3	55324	broad.mit.edu	37	chr3	183905711	183905711	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagagtcggttggaatcatCtggcaagaacaaatcctatg	13	9	12	7	1	2	2	1	0	1	2	4	4	3	3	1	4	1	2	1	4	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:183905711C>T	uc003fmz.2	+	6	642	c.509C>T	c.(508-510)TCT>TTT	p.S170F	ABCF3_uc003fna.2_Missense_Mutation_p.S164F|ABCF3_uc003fnb.2_5'Flank	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	170							ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTGGAATCATCTGGCAAGAAC	0.478													11	117					0	0	0	0	T	183905711	T	T	183905711	3	4	154	1	0	0	0	0	1	0	0	0	67	913	32	2	531	2	ABCF3	3	183905711	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	876991	183905711	14116719	195	28042											
KNG1	3827	broad.mit.edu	37	chr3	186450368	186450368	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaccaacagcccagagctgGaggagacactgactcacacc	13	3	9	16	0	1	3	1	1	0	2	1	5	1	4	4	2	3	1	4	2	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr3:186450368G>T	uc011bsa.1	+	7	1047	c.835G>T	c.(835-837)GAG>TAG	p.E279*	KNG1_uc003fqr.2_Nonsense_Mutation_p.E279*	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	279	Cystatin 3.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CCCAGAGCTGGAGGAGACACT	0.448													6	145					2.0095e-06	4.12217e-06	1	0	T	186450368	T	T	186450368	4	4	154	1	0	0	0	0	0	1	0	0	8466	1175	41	2	861	2	KNG1	3	186450368	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2544657	186450368	11572062	196	28043											
CLRN2	645104	broad.mit.edu	37	chr4	17528565	17528565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtggaagaacagtatgaaGagtcgttttggatctgcgtg	10	12	15	4	2	1	3	0	1	1	2	2	5	1	5	0	3	2	2	0	3	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:17528565G>A	uc003gpg.1	+	3	661	c.559G>A	c.(559-561)GAG>AAG	p.E187K		NM_001079827	NP_001073296	A0PK11	CLRN2_HUMAN	clarin 2	187						integral to membrane					0						ACAGTATGAAGAGTCGTTTTG	0.517													7	43					0	0	0	0	A	17528565	A	A	17528565	3	1	154	1	0	0	0	0	1	0	0	0	3573	943	33	2	569	2	CLRN2	4	17528565	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08		17528565	173625711	197	28044											
KCTD8	386617	broad.mit.edu	37	chr4	44177183	44177183	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agagctcattacaggaagtcCcactttcacttcctttatca	11	13	5	12	0	3	1	3	0	0	1	5	2	5	2	2	1	2	1	2	1	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:44177183C>A	uc003gwu.2	-	2	1330	c.1046G>T	c.(1045-1047)GGG>GTG	p.G349V		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	349						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						ACAGGAAGTCCCACTTTCACT	0.463										HNSCC(17;0.042)			13	30					4.3838e-07	9.19657e-07	1	0	A	44177183	A	A	44177183	3	1	154	1	0	0	0	0	1	0	0	0	8154	623	22	4	379	4	KCTD8	4	44177183	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	26648618	44177183	146977093	198	28045											
SPATA18	132671	broad.mit.edu	37	chr4	52938153	52938153	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggagctcagagaataggCggtcagagccttggagcttg	11	7	16	7	1	2	3	2	0	0	3	2	6	2	5	1	4	3	2	1	4	2	3	rs146272260	by1000genomes	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:52938153C>A	uc003gzl.2	+	6	867	c.589C>A	c.(589-591)CGG>AGG	p.R197R	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Silent_p.R165R|SPATA18_uc003gzk.1_Silent_p.R197R	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	197					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			AGAGAATAGGCGGTCAGAGCC	0.478													7	38					8.12818e-05	0.000159302	1	0	A	52938153	A	A	52938153	2	1	154	1	0	0	0	0	0	0	0	1	15069	759	27	3		3	SPATA18	4	52938153	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	8760970	52938153	138216123	199	28046											
PDGFRA	5156	broad.mit.edu	37	chr4	55131137	55131137	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttaaaaccgtgtataagtCaggggaaacgattgtggtca	13	11	11	6	2	3	0	2	0	1	0	3	2	3	1	1	3	2	1	1	3	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:55131137C>A	uc003han.3	+	5	1011	c.680C>A	c.(679-681)TCA>TAA	p.S227*	PDGFRA_uc003haa.2_Intron|PDGFRA_uc003hal.2_3'UTR|PDGFRA_uc010igq.1_Nonsense_Mutation_p.S121*|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	227	Ig-like C2-type 3.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTGTATAAGTCAGGGGAAACG	0.433			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			26	100					2.44723e-14	5.79816e-14	1	0	A	55131137	A	A	55131137	4	1	154	1	0	0	0	0	0	1	0	0	11715	838	29	2	694	2	PDGFRA	4	55131137	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2192984	55131137	136023139	200	28047											
UGT2B10	7365	broad.mit.edu	37	chr4	69875669	69875669	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtatccacctgtacagcCgagtattgagacctaaggca	11	8	12	10	1	0	1	0	1	0	1	1	3	1	1	4	3	2	4	4	3	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:69875669C>A	uc011cao.1	-	7	1077	c.941G>T	c.(940-942)CGA>CTA	p.R314L	UGT2B10_uc011can.1_Missense_Mutation_p.R230L			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	351					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						CCTGTACAGCCGAGTATTGAG	0.383													7	75					5.18039e-06	1.05407e-05	1	0	A	69875669	A	A	69875669	3	1	154	1	0	0	0	0	1	0	0	0	17024	652	23	3	2157	3	UGT2B10	4	69875669	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	14744532	69875669	121278607	201	28048											
UGT2B11	10720	broad.mit.edu	37	chr4	70079865	70079865	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacataacaataggtatgtaGgaaggagggaaaatcagtcc	17	7	12	5	0	1	0	1	0	0	0	2	4	2	3	1	4	1	2	1	4	8	4	rs148942208	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:70079865G>T	uc003heh.2	-	1	585	c.576C>A	c.(574-576)TCC>TCA	p.S192S	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	192					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						TAGGTATGTAGGAAGGAGGGA	0.393													15	65					0.00316338	0.00590363	1	0	T	70079865	T	T	70079865	2	4	154	1	0	0	0	0	0	0	0	1	17025	987	35	4		4	UGT2B11	4	70079865	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	204196	70079865	121074411	202	28049											
MUC7	4589	broad.mit.edu	37	chr4	71347573	71347573	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaatctactaaacagaattaTtgacgacatggtggagcaat	16	10	9	6	1	1	2	0	1	1	1	1	5	1	3	0	2	3	1	0	2	7	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:71347573T>C	uc011cat.1	+	4	1400	c.1112T>C	c.(1111-1113)ATT>ACT	p.I371T	MUC7_uc011cau.1_Missense_Mutation_p.I371T|MUC7_uc003hfj.2_Missense_Mutation_p.I371T|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	371						extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			AACAGAATTATTGACGACATG	0.333													12	46					0	0	0	0	C	71347573	C	C	71347573	3	2	154	1	0	0	0	0	1	0	0	0	10034	1493	52	5	1118	5	MUC7	4	71347573	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1267708	71347573	119806703	203	28050											
AMTN	401138	broad.mit.edu	37	chr4	71396868	71396868	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggaagccttccagcaggagGagcaggtgtaaatcctgcca	11	7	13	10	0	0	0	0	0	0	0	2	3	2	3	4	4	4	3	4	4	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:71396868G>T	uc003hfk.1	+	8	559	c.470G>T	c.(469-471)GGA>GTA	p.G157V	AMTN_uc010ihy.1_Missense_Mutation_p.G156V	NM_212557	NP_997722	Q6UX39	AMTN_HUMAN	amelotin precursor	157					biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				large_intestine(1)|central_nervous_system(1)	2			Lung(101;0.235)			CCAGCAGGAGGAGCAGGTGTA	0.607													11	32					4.68919e-08	9.99224e-08	1	0	T	71396868	T	T	71396868	3	4	154	1	0	0	0	0	1	0	0	0	590	1174	41	2	496	2	AMTN	4	71396868	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	49295	71396868	119757408	204	28051											
NPFFR2	10886	broad.mit.edu	37	chr4	72897759	72897759	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gggccagcctggagcggaagCctggagtggagcaggcagtc	8	4	19	10	1	0	0	0	0	0	0	1	4	0	4	3	6	4	2	3	6	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:72897759C>G	uc003hgg.2	+	1	239	c.141C>G	c.(139-141)AGC>AGG	p.S47R	NPFFR2_uc010iig.1_5'UTR	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	47	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GGAGCGGAAGCCTGGAGTGGA	0.662													7	36					0	0	0	0	G	72897759	G	G	72897759	3	3	154	1	0	0	0	0	1	0	0	0	10632	738	26	4	143	4	NPFFR2	4	72897759	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1500891	72897759	118256517	205	28052											
ANKRD17	26057	broad.mit.edu	37	chr4	74043106	74043106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagtacatacctgcagcttCtagtaaagcttccagtctag	12	11	8	10	0	2	1	0	0	2	1	3	1	3	1	2	0	5	5	2	0	6	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:74043106C>T	uc003hgp.2	-	2	655	c.538G>A	c.(538-540)GAA>AAA	p.E180K	ANKRD17_uc003hgo.2_Missense_Mutation_p.E67K|ANKRD17_uc003hgq.2_Missense_Mutation_p.E180K|ANKRD17_uc003hgr.2_Missense_Mutation_p.E180K	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	180					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCTGCAGCTTCTAGTAAAGCT	0.398													7	73					0	0	0	0	T	74043106	T	T	74043106	3	4	154	1	0	0	0	0	1	0	0	0	646	922	32	2	7405	2	ANKRD17	4	74043106	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1145347	74043106	117111170	206	28053											
CXCL13	10563	broad.mit.edu	37	chr4	78528901	78528901	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgaggtgtagatgtgtcCaagagagctcagtctttatc	9	13	12	7	0	2	3	1	1	1	2	4	4	3	3	1	1	1	3	1	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:78528901C>A	uc003hkr.2	+	3	187	c.109C>A	c.(109-111)CAA>AAA	p.Q37K		NM_006419	NP_006410	O43927	CXL13_HUMAN	chemokine (C-X-C motif) ligand 13 (B-cell	37					activation of Rap GTPase activity|B cell chemotaxis|cell-cell signaling|chronic inflammatory response|defense response to bacterium|elevation of cytosolic calcium ion concentration|endothelial cell chemotaxis to fibroblast growth factor|germinal center formation|lymphocyte chemotaxis across high endothelial venule|negative regulation of apoptosis|positive regulation of cell-cell adhesion mediated by integrin|positive regulation of integrin activation|positive regulation of T cell chemotaxis|regulation of angiogenesis|regulation of humoral immune response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|CXCR3 chemokine receptor binding|CXCR5 chemokine receptor binding|fibroblast growth factor 2 binding|heparin binding|protein heterodimerization activity|receptor agonist activity				0						TAGATGTGTCCAAGAGAGCTC	0.388													17	70					1.01871e-10	2.28722e-10	1	0	A	78528901	A	A	78528901	3	1	154	1	0	0	0	0	1	0	0	0	4098	595	21	4	115	4	CXCL13	4	78528901	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4485795	78528901	112625375	207	28054											
FRAS1	80144	broad.mit.edu	37	chr4	79455626	79455626	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgatacccattgcattccAgcagaccaaccgccctgtgc	9	8	7	17	1	0	2	0	1	0	1	1	2	1	2	6	0	5	2	6	0	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:79455626A>T	uc003hlb.2	+	71	11389	c.10949A>T	c.(10948-10950)CAG>CTG	p.Q3650L		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3645	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ATTGCATTCCAGCAGACCAAC	0.443													32	142					0	0	0	0	T	79455626	T	T	79455626	3	4	154	1	0	0	0	0	1	0	0	0	6076	188	7	5	11306	5	FRAS1	4	79455626	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	926725	79455626	111698650	208	28055											
WDFY3	23001	broad.mit.edu	37	chr4	85781681	85781681	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtgcatcagtcctaaggCgttgtcttgtgggctgcact	6	12	14	9	1	2	0	1	0	1	0	3	1	3	0	1	3	2	4	1	3	1	3	rs138518540	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:85781681C>G	uc003hpd.2	-	4	472	c.64G>C	c.(64-66)GCC>CCC	p.A22P	WDFY3_uc003hpf.2_Missense_Mutation_p.A22P	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	22						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGTCCTAAGGCGTTGTCTTGT	0.542													12	55					0	0	0	0	G	85781681	G	G	85781681	3	3	154	1	0	0	0	0	1	0	0	0	17338	768	27	3	10819	3	WDFY3	4	85781681	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6326055	85781681	105372595	209	28056											
MMRN1	22915	broad.mit.edu	37	chr4	90857200	90857200	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgattctattcagactttggTcaatgacaatcagagatata	14	14	7	6	0	4	4	3	2	1	2	4	5	4	4	0	1	0	0	0	1	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:90857200T>G	uc003hst.2	+	6	2440	c.2369T>G	c.(2368-2370)GTC>GGC	p.V790G	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.V532G	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	790					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CAGACTTTGGTCAATGACAAT	0.378													7	58					0	0	0	0	G	90857200	G	G	90857200	3	3	154	1	0	0	0	0	1	0	0	0	9723	1667	58	5	2391	5	MMRN1	4	90857200	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	5075519	90857200	100297076	210	28057											
ATOH1	474	broad.mit.edu	37	chr4	94750474	94750474	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacagctgtgcaagctgaaaGgcggggtggtggtagacgag	11	6	18	6	2	0	2	0	1	0	1	0	3	0	2	0	5	4	4	0	5	4	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:94750474G>C	uc003hta.1	+	1	397	c.397G>C	c.(397-399)GGC>CGC	p.G133R		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	133					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		CAAGCTGAAAGGCGGGGTGGT	0.672													3	44					0	0	0	0	C	94750474	C	C	94750474	3	2	154	1	0	0	0	0	1	0	0	0	1114	1000	35	4	399	4	ATOH1	4	94750474	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3893274	94750474	96403802	211	28058											
HPGDS	27306	broad.mit.edu	37	chr4	95223375	95223375	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaggcgcattatacgtgagCagctcattgaacatctgctc	10	11	10	10	2	2	3	1	3	1	0	3	3	2	3	0	1	5	4	0	1	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:95223375C>T	uc003hte.1	-	5	448	c.357G>A	c.(355-357)CTG>CTA	p.L119L		NM_014485	NP_055300	O60760	HPGDS_HUMAN	prostaglandin D2 synthase, hematopoietic	119	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			ovary(1)	1					Glutathione(DB00143)	TATACGTGAGCAGCTCATTGA	0.378													45	163					0	0	0	0	T	95223375	T	T	95223375	2	4	154	1	0	0	0	0	0	0	0	1	7374	697	25	4		4	HPGDS	4	95223375	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	472901	95223375	95930901	212	28059											
UNC5C	8633	broad.mit.edu	37	chr4	96256640	96256640	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttacacttgaaatagatctgGgtggcagggcttgctttaca	10	13	11	7	0	1	2	0	1	1	1	1	2	1	2	0	3	3	3	0	3	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:96256640G>T	uc003htp.1	-	2	421	c.267C>A	c.(265-267)ACC>ACA	p.T89T	UNC5C_uc010ilc.1_Silent_p.T89T|UNC5C_uc003htq.2_Silent_p.T89T	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	89	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		AATAGATCTGGGTGGCAGGGC	0.428													20	46					1.50039e-11	3.40786e-11	1	0	T	96256640	T	T	96256640	2	4	154	1	0	0	0	0	0	0	0	1	17061	1219	43	4		4	UNC5C	4	96256640	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1033265	96256640	94897636	213	28060											
TET2	54790	broad.mit.edu	37	chr4	106156786	106156786	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagcactatctgaaaccaGgatggattgaattgaaggcc	14	8	10	9	0	1	3	0	3	1	0	1	5	1	5	2	3	2	1	2	3	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:106156786G>T	uc003hxk.2	+	3	2073	c.1687G>T	c.(1687-1689)GGA>TGA	p.G563*	TET2_uc011cez.1_Nonsense_Mutation_p.G584*|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Nonsense_Mutation_p.G563*|TET2_uc003hxi.1_Nonsense_Mutation_p.G563*	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	563					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TCTGAAACCAGGATGGATTGA	0.463			Mis N|F		MDS								21	73					9.95505e-16	2.39084e-15	1	0	T	106156786	T	T	106156786	4	4	154	1	0	0	0	0	0	1	0	0	15836	1001	35	4	1689	4	TET2	4	106156786	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	9900146	106156786	84997490	214	28061											
FABP2	2169	broad.mit.edu	37	chr4	120240198	120240198	+	Nonstop_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcgccaagaataatgctcAatcctttttaaagatccttt	12	14	6	9	1	1	2	1	0	0	2	3	2	3	2	3	0	2	1	3	0	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:120240198A>T	uc003icw.2	-	4	456	c.397T>A	c.(397-399)TGA>AGA	p.*133R		NM_000134	NP_000125	P12104	FABPI_HUMAN	intestinal fatty acid binding protein 2	133							fatty acid binding			ovary(1)	1						AATAATGCTCAATCCTTTTTA	0.328													14	74					0	0	0	0	T	120240198	T	T	120240198	4	4	154	1	0	0	0	0	0	0	0	0	5385	143	5	5	5	5	FABP2	4	120240198	Nonstop_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	14083412	120240198	70914078	215	28062											
EXOSC9	5393	broad.mit.edu	37	chr4	122734498	122734498	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggatgtagaagaaaaagcaGaagaaatcattgctgaagca	19	6	11	5	1	1	5	1	1	0	4	1	6	1	6	0	1	3	4	0	1	7	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:122734498G>A	uc003iea.2	+	9	1045	c.937G>A	c.(937-939)GAA>AAA	p.E313K	EXOSC9_uc003idz.2_Missense_Mutation_p.E313K|EXOSC9_uc003ieb.2_Missense_Mutation_p.E297K|EXOSC9_uc010inp.1_Intron	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	313					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						AGAAAAAGCAGAAGAAATCAT	0.363													10	111					0	0	0	0	A	122734498	A	A	122734498	3	1	154	1	0	0	0	0	1	0	0	0	5346	943	33	2	971	2	EXOSC9	4	122734498	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2494300	122734498	68419778	216	28063											
ANKRD50	57182	broad.mit.edu	37	chr4	125593540	125593540	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagaaagcatccactgctttTaatgtgcagttgatttaaca	14	13	7	7	0	0	2	0	1	0	1	1	2	1	2	1	0	4	4	1	0	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:125593540T>C	uc003ifg.3	-	3	1158	c.892A>G	c.(892-894)AAA>GAA	p.K298E	ANKRD50_uc011cgo.1_Missense_Mutation_p.K119E|ANKRD50_uc010inw.2_Missense_Mutation_p.K298E	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	298										central_nervous_system(1)	1						CCACTGCTTTTAATGTGCAGT	0.363													8	28					0	0	0	0	C	125593540	C	C	125593540	3	2	154	1	0	0	0	0	1	0	0	0	677	1763	61	5	3401	5	ANKRD50	4	125593540	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	2859042	125593540	65560736	217	28064											
FAT4	79633	broad.mit.edu	37	chr4	126242430	126242430	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaattgaccatcattcttCagggccttgatggacctgtt	8	14	9	10	0	3	3	2	3	1	0	3	4	3	4	3	2	0	1	3	2	1	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:126242430C>G	uc003ifj.3	+	1	4864	c.4864C>G	c.(4864-4866)CAG>GAG	p.Q1622E		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1622	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CATCATTCTTCAGGGCCTTGA	0.428													16	106					0	0	0	0	G	126242430	G	G	126242430	3	3	154	1	0	0	0	0	1	0	0	0	5724	827	29	2	4866	2	FAT4	4	126242430	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	648890	126242430	64911846	218	28065											
SLC25A31	83447	broad.mit.edu	37	chr4	128685492	128685492	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctagattttgcccgaacccGattaggtgtcgatattggaa	10	13	10	8	3	1	1	0	0	1	1	2	5	1	2	2	2	2	0	2	2	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:128685492G>A	uc003ifl.2	+	3	601	c.455G>A	c.(454-456)CGA>CAA	p.R152Q		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	152	Solcar 2.				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						GCCCGAACCCGATTAGGTGTC	0.398													7	40					0	0	0	0	A	128685492	A	A	128685492	3	1	154	1	0	0	0	0	1	0	0	0	14559	1058	37	1	465	1	SLC25A31	4	128685492	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2443062	128685492	62468784	219	28066											
ZNF827	152485	broad.mit.edu	37	chr4	146806946	146806946	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcagctttgtgtggttggcgGgcctgtcggcagcattcaaa	6	12	14	9	2	2	0	2	0	0	0	3	0	2	0	1	4	2	4	1	4	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:146806946G>A	uc003ikn.2	-	4	1679	c.1631C>T	c.(1630-1632)CCC>CTC	p.P544L	ZNF827_uc003ikm.2_Missense_Mutation_p.P544L|ZNF827_uc010iox.2_Missense_Mutation_p.P194L	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	544					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					GTGGTTGGCGGGCCTGTCGGC	0.557													8	56					0	0	0	0	A	146806946	A	A	146806946	3	1	154	1	0	0	0	0	1	0	0	0	18247	1232	43	4	1642	4	ZNF827	4	146806946	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	18121454	146806946	44347330	220	28067											
NR3C2	4306	broad.mit.edu	37	chr4	149357050	149357050	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggctgccggactggaaagCgtggatctgttattagtgtt	7	13	14	7	2	1	0	0	0	1	0	1	3	1	3	1	4	2	3	1	4	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:149357050C>A	uc003ilj.3	-	2	1297	c.963G>T	c.(961-963)ACG>ACT	p.T321T	NR3C2_uc003ilk.3_Silent_p.T321T|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	321	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GACTGGAAAGCGTGGATCTGT	0.483													16	75					0.000422831	0.000815063	1	0	A	149357050	A	A	149357050	2	1	154	1	0	0	0	0	0	0	0	1	10685	755	27	3		3	NR3C2	4	149357050	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2550104	149357050	41797226	221	28068											
DCLK2	166614	broad.mit.edu	37	chr4	151000270	151000270	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaggggcccccagctccTccgggggcagcagcagctcg	6	3	17	15	2	0	1	0	0	0	1	3	2	2	1	4	5	4	5	4	5	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:151000270T>C	uc003ilm.3	+	1	191	c.91T>C	c.(91-93)TCC>CCC	p.S31P	DCLK2_uc003iln.3_Missense_Mutation_p.S31P|DCLK2_uc003ilo.3_Missense_Mutation_p.S31P|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	31					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					CCCCAGCTCCTCCGGGGGCAG	0.706													9	13					0	0	0	0	C	151000270	C	C	151000270	3	2	154	1	0	0	0	0	1	0	0	0	4309	1551	54	5	93	5	DCLK2	4	151000270	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1643220	151000270	40154006	222	28069											
DCHS2	54798	broad.mit.edu	37	chr4	155236942	155236942	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccctggtaacaaactcccCtggattttggttttctttca	9	15	6	11	0	2	0	1	0	1	0	3	1	3	1	3	3	3	2	3	3	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:155236942C>A	uc003inw.2	-	15	3853	c.3853G>T	c.(3853-3855)GGG>TGG	p.G1285W		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1285	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ACAAACTCCCCTGGATTTTGG	0.368													7	75					1.06961e-07	2.26552e-07	1	0	A	155236942	A	A	155236942	3	1	154	1	0	0	0	0	1	0	0	0	4305	681	24	4	4941	4	DCHS2	4	155236942	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4236672	155236942	35917334	223	28070											
MAP9	79884	broad.mit.edu	37	chr4	156289867	156289867	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtttctttatcttctagTccatccttctcctccatgtg	5	18	5	13	0	4	0	0	0	4	0	8	0	7	0	4	0	0	2	4	0	2	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:156289867T>A	uc003ios.2	-	5	843	c.579A>T	c.(577-579)GGA>GGT	p.G193G	MAP9_uc011cin.1_Silent_p.G192G|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Silent_p.G192G|MAP9_uc010iqb.1_Silent_p.G120G	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	193	Potential.				cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TATCTTCTAGTCCATCCTTCT	0.428													15	78					0	0	0	0	A	156289867	A	A	156289867	2	1	154	1	0	0	0	0	0	0	0	1	9323	1654	58	5		5	MAP9	4	156289867	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1052925	156289867	34864409	224	28071											
ZFP42	132625	broad.mit.edu	37	chr4	188924519	188924519	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagaatatgacagtctgagCgcaatcgcttgtcctcagag	13	9	10	9	2	2	4	1	2	1	2	4	4	3	4	1	0	1	2	1	0	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:188924519C>A	uc003izg.1	+	3	803	c.558C>A	c.(556-558)AGC>AGA	p.S186R	ZFP42_uc003izh.1_Missense_Mutation_p.S186R|ZFP42_uc003izi.1_Missense_Mutation_p.S186R	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	186					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		ACAGTCTGAGCGCAATCGCTT	0.493													31	98					2.09667e-21	5.14796e-21	1	0	A	188924519	A	A	188924519	3	1	154	1	0	0	0	0	1	0	0	0	17717	767	27	3	560	3	ZFP42	4	188924519	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	32634652	188924519	2229757	225	28072											
TRIML2	205860	broad.mit.edu	37	chr4	189018247	189018247	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaacatgctgctgagtcctCttatgtggcataaactcagg	10	12	10	9	0	2	2	1	2	1	0	3	2	3	2	1	2	4	3	1	2	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr4:189018247C>G	uc003izl.2	-	6	599	c.563G>C	c.(562-564)AGA>ACA	p.R188T	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Missense_Mutation_p.R263T	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	188	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GCTGAGTCCTCTTATGTGGCA	0.493													12	112					0	0	0	0	G	189018247	G	G	189018247	3	3	154	1	0	0	0	0	1	0	0	0	16618	913	32	2	608	2	TRIML2	4	189018247	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	93728	189018247	2136029	226	28073											
ADAMTS16	170690	broad.mit.edu	37	chr5	5237159	5237159	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaaataaagtcaaagatGggactccatgctcggaggat	14	9	11	7	1	2	1	2	0	0	1	4	4	3	4	1	3	1	1	1	3	4	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:5237159G>T	uc003jdl.2	+	14	2239	c.2101G>T	c.(2101-2103)GGG>TGG	p.G701W	ADAMTS16_uc003jdk.1_Missense_Mutation_p.G701W|ADAMTS16_uc010itk.1_Intron	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	701	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						AGTCAAAGATGGGACTCCATG	0.308													16	55					4.14922e-12	9.54754e-12	1	0	T	5237159	T	T	5237159	3	4	154	1	0	0	0	0	1	0	0	0	261	1348	47	4	2155	4	ADAMTS16	5	5237159	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08		5237159	175678101	227	28074											
KIAA0947	23379	broad.mit.edu	37	chr5	5462953	5462953	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactttttctgagctggataGactttccacatcagaggttg	9	15	9	8	0	2	3	1	1	1	2	3	4	3	4	1	2	2	2	1	2	2	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:5462953G>A	uc003jdm.3	+	13	3728	c.3506G>A	c.(3505-3507)AGA>AAA	p.R1169K		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1169										ovary(1)|central_nervous_system(1)	2						GAGCTGGATAGACTTTCCACA	0.428													6	14					0	0	0	0	A	5462953	A	A	5462953	3	1	154	1	0	0	0	0	1	0	0	0	8241	942	33	2	3556	2	KIAA0947	5	5462953	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	225794	5462953	175452307	228	28075											
NSUN2	54888	broad.mit.edu	37	chr5	6611186	6611186	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctgtaaaccactgcccatCtttcgtcattacctgcagaa	10	12	6	13	1	3	1	1	0	2	1	4	1	3	1	3	0	4	2	3	0	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:6611186C>T	uc003jdu.2	-	11	1173	c.1108G>A	c.(1108-1110)GAT>AAT	p.D370N	NSUN2_uc003jdt.2_Missense_Mutation_p.D134N|NSUN2_uc011cmk.1_Missense_Mutation_p.D335N|NSUN2_uc003jdv.2_Missense_Mutation_p.D134N	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	370						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						CACTGCCCATCTTTCGTCATT	0.502													20	80					0	0	0	0	T	6611186	T	T	6611186	3	4	154	1	0	0	0	0	1	0	0	0	10732	913	32	2	1231	2	NSUN2	5	6611186	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1148233	6611186	174304074	229	28076											
CTNND2	1501	broad.mit.edu	37	chr5	11018126	11018126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatctcggtactgccacatgCtgttgaggacctgagatgca	9	10	12	10	1	1	2	0	2	1	1	2	5	1	3	2	2	4	4	2	2	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:11018126C>T	uc003jfa.1	-	18	3189	c.3044G>A	c.(3043-3045)AGC>AAC	p.S1015N	CTNND2_uc010itt.2_Missense_Mutation_p.S924N|CTNND2_uc011cmy.1_Missense_Mutation_p.S678N|CTNND2_uc011cmz.1_Missense_Mutation_p.S582N|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.S607N	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1015	ARM 9.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CTGCCACATGCTGTTGAGGAC	0.493													7	82					0	0	0	0	T	11018126	T	T	11018126	3	4	154	1	0	0	0	0	1	0	0	0	4037	797	28	4	653	4	CTNND2	5	11018126	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4406940	11018126	169897134	230	28077											
CTNND2	1501	broad.mit.edu	37	chr5	11364946	11364946	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgttctggggactgcagggCccgcaactctgggcccaggt	5	8	16	12	1	2	0	0	0	2	0	2	1	2	1	2	5	2	3	2	5	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:11364946C>G	uc003jfa.1	-	8	1379	c.1234G>C	c.(1234-1236)GCC>CCC	p.A412P	CTNND2_uc010itt.2_Missense_Mutation_p.A321P|CTNND2_uc011cmy.1_Missense_Mutation_p.A75P|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	412	ARM 1.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GACTGCAGGGCCCGCAACTCT	0.582													16	86					0	0	0	0	G	11364946	G	G	11364946	3	3	154	1	0	0	0	0	1	0	0	0	4037	739	26	4	2503	4	CTNND2	5	11364946	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	346820	11364946	169550314	231	28078											
DNAH5	1767	broad.mit.edu	37	chr5	13870965	13870966	+	Missense_Mutation	DNP	CC	AA	AA																															aatccgaatatcatctaggtCcttaattggacgatttagtt																								rs140471516		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:13870965_13870966CC>AA	uc003jfd.2	-	24	3786_3787	c.3744_3745GG>TT	c.(3742-3747)AAGGAC>AATTAC	p.1248_1249KD>NY		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1248_1249	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCATCTAGGTCCTTAATTGGAC	0.371									Kartagener_syndrome				10	46					0	0	0	0	AA	13870966	AA	AA	13870965	3	1	154	1	0	0	0	0	1	0	0	0	4626	855	30	2	10353	2	DNAH5	5	13870965	Missense_Mutation	DNP	CC	TCGA-CR-7388-01A-11D-2012-08	2506019	13870965	167044295	232	28079											
NIPBL	25836	broad.mit.edu	37	chr5	36953855	36953855	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgcggggattgctagtctCacagaccgtaagtttggtta	8	13	12	8	2	1	1	1	0	1	1	2	2	1	2	1	3	2	4	1	3	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:36953855C>T	uc003jkl.3	+	2	556	c.57C>T	c.(55-57)CTC>CTT	p.L19L	NIPBL_uc003jkk.3_Silent_p.L19L	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	19					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TTGCTAGTCTCACAGACCGTA	0.348													21	61					0	0	0	0	T	36953855	T	T	36953855	2	4	154	1	0	0	0	0	0	0	0	1	10482	813	29	2		2	NIPBL	5	36953855	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	23082890	36953855	143961405	233	28080											
NIPBL	25836	broad.mit.edu	37	chr5	37003451	37003451	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttccactttgttaaatcatgTaagtttaagatccatactgt	12	17	5	7	0	1	1	1	0	0	1	3	1	3	1	2	0	1	3	2	0	5	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:37003451T>C	uc003jkl.3	+	16	4354	c.3855_splice	c.e16+2	p.H1285_splice	NIPBL_uc003jkk.3_Splice_Site_p.H1285_splice	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A						brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TTAAATCATGTAAGTTTAAGA	0.224													15	98					0	0	0	0	C	37003451	C	C	37003451	5	2	154	1	0	0	0	0	0	0	1	0	10482	1652	57	5	3915	5	NIPBL	5	37003451	Splice_Site	SNP	T	TCGA-CR-7388-01A-11D-2012-08	49596	37003451	143911809	234	28081											
C9	735	broad.mit.edu	37	chr5	39341354	39341354	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctgaaaagtctccgcagtCattgtcaccattacaccgaa	13	10	6	12	2	4	1	2	1	2	0	5	2	4	1	3	0	1	1	3	0	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:39341354C>T	uc003jlv.3	-	4	459	c.370G>A	c.(370-372)GAC>AAC	p.D124N		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	124	LDL-receptor class A.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			TCTCCGCAGTCATTGTCACCA	0.463													10	74					0	0	0	0	T	39341354	T	T	39341354	3	4	154	1	0	0	0	0	1	0	0	0	2455	826	29	2	1341	2	C9	5	39341354	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2337903	39341354	141573906	235	28082											
C5orf51	285636	broad.mit.edu	37	chr5	41904501	41904501	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtctctagtgtggtgagacGagtggaagagctcggggatc	9	9	17	6	2	1	2	0	1	1	2	4	6	1	4	0	4	1	1	0	4	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:41904501G>A	uc003jmo.2	+	1	32	c.32G>A	c.(31-33)CGA>CAA	p.R11Q		NM_175921	NP_787117	A6NDU8	CE051_HUMAN	hypothetical protein LOC285636	11											0						GTGGTGAGACGAGTGGAAGAG	0.662													6	31					0	0	0	0	A	41904501	A	A	41904501	3	1	154	1	0	0	0	0	1	0	0	0	2318	1058	37	1	34	1	C5orf51	5	41904501	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2563147	41904501	139010759	236	28083											
HTR1A	3350	broad.mit.edu	37	chr5	63256751	63256751	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccagccttgctctccacgcCcagcctccagttcctgctcc	4	9	6	22	1	1	0	0	0	1	0	5	0	4	0	8	0	4	3	8	0	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:63256751C>G	uc011cqt.1	-	1	796	c.796G>C	c.(796-798)GGC>CGC	p.G266R		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	266	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CTCTCCACGCCCAGCCTCCAG	0.672													9	94					0	0	0	0	G	63256751	G	G	63256751	3	3	154	1	0	0	0	0	1	0	0	0	7475	623	22	4	475	4	HTR1A	5	63256751	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	21352250	63256751	117658509	237	28084											
MAP1B	4131	broad.mit.edu	37	chr5	71482446	71482446	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctttatttcaggtgcgCttaatgatcactgatgctgc	7	16	10	8	1	2	2	2	2	0	0	2	2	2	2	0	1	4	3	0	1	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:71482446C>A	uc003kbw.3	+	4	616	c.375C>A	c.(373-375)CGC>CGA	p.R125R	MAP1B_uc010iyw.1_Silent_p.R125R|MAP1B_uc010iyx.1_5'UTR|MAP1B_uc010iyy.1_5'UTR	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	125						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TTCAGGTGCGCTTAATGATCA	0.552													15	92					0.000422831	0.000815063	1	0	A	71482446	A	A	71482446	2	1	154	1	0	0	0	0	0	0	0	1	9281	784	28	4		4	MAP1B	5	71482446	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	8225695	71482446	109432814	238	28085											
CMYA5	202333	broad.mit.edu	37	chr5	79030276	79030276	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggatgaaaactggatgttGggaaagccagaaaatgtggc	16	7	14	4	0	0	2	0	1	0	1	0	5	0	5	1	4	2	1	1	4	6	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:79030276G>T	uc003kgc.2	+	2	5760	c.5688G>T	c.(5686-5688)TTG>TTT	p.L1896F		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1896						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ACTGGATGTTGGGAAAGCCAG	0.433													11	52					4.68919e-08	9.99224e-08	1	0	T	79030276	T	T	79030276	3	4	154	1	0	0	0	0	1	0	0	0	3605	1339	47	4	5694	4	CMYA5	5	79030276	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	7547830	79030276	101884984	239	28086											
DHFR	1719	broad.mit.edu	37	chr5	79945217	79945217	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtacttacttgagttctCtgctgagaactaaattaatt	13	15	7	6	0	1	2	0	2	1	1	2	3	1	2	0	1	4	3	0	1	7	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:79945217C>T	uc003kgy.1	-	3	725	c.233G>A	c.(232-234)AGA>AAA	p.R78K	DHFR_uc011ctl.1_Missense_Mutation_p.R158K|DHFR_uc011ctm.1_Missense_Mutation_p.R26K|DHFR_uc010jap.1_RNA|DHFR_uc003kgx.1_Missense_Mutation_p.R227K	NM_000791	NP_000782	P00374	DYR_HUMAN	dihydrofolate reductase	78	NADP.|DHFR.				folic acid metabolic process|glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to methotrexate|tetrahydrofolate metabolic process	cytosol	dihydrofolate reductase activity|drug binding|folate reductase activity|NADP binding				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.69e-46)|Epithelial(54;7.49e-41)|all cancers(79;1.54e-35)	Dapsone(DB00250)|Dimethyl sulfoxide(DB01093)|Lamotrigine(DB00555)|Methotrexate(DB00563)|NADH(DB00157)|Pemetrexed(DB00642)|Proguanil(DB01131)|Pyrimethamine(DB00205)|Trimethoprim(DB00440)|Trimetrexate(DB01157)	CTTGAGTTCTCTGCTGAGAAC	0.343													9	34					0	0	0	0	T	79945217	T	T	79945217	3	4	154	1	0	0	0	0	1	0	0	0	4503	913	32	2	346	2	DHFR	5	79945217	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	914941	79945217	100970043	240	28087											
RASGRF2	5924	broad.mit.edu	37	chr5	80376426	80376426	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttgcagctgatctgtttGatattttgctccccatgctg	5	18	8	10	0	2	2	0	2	2	0	3	2	3	2	2	0	4	5	2	0	1	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:80376426G>C	uc003kha.1	+	7	979	c.979G>C	c.(979-981)GAT>CAT	p.D327H	RASGRF2_uc011ctn.1_RNA|RASGRF2_uc003khb.1_Missense_Mutation_p.D155H	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	327	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TGATCTGTTTGATATTTTGCT	0.433													11	64					0	0	0	0	C	80376426	C	C	80376426	3	2	154	1	0	0	0	0	1	0	0	0	13138	1290	45	2	1005	2	RASGRF2	5	80376426	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	431209	80376426	100538834	241	28088											
GPR98	84059	broad.mit.edu	37	chr5	90073767	90073767	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggggaggtcacagtgttctgGaggatattccctccttccgt	6	12	13	10	1	2	0	1	0	1	0	5	3	5	3	3	5	0	1	3	5	1	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:90073767G>C	uc003kju.2	+	62	12669	c.12573G>C	c.(12571-12573)TGG>TGC	p.W4191C	GPR98_uc003kjt.2_Missense_Mutation_p.W1897C	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4191	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CAGTGTTCTGGAGGATATTCC	0.428													6	17					0	0	0	0	C	90073767	C	C	90073767	3	2	154	1	0	0	0	0	1	0	0	0	6760	1183	41	2	12819	2	GPR98	5	90073767	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	9697341	90073767	90841493	242	28089											
TTC37	9652	broad.mit.edu	37	chr5	94842665	94842665	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atctgccgtaatttcttattGcaacattgtaagtatcttgg	10	17	7	7	1	3	0	0	0	3	0	3	0	3	0	1	1	3	4	1	1	5	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:94842665G>A	uc003klb.2	-	30	3335	c.3065C>T	c.(3064-3066)GCA>GTA	p.A1022V		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1022	TPR 17.						binding			ovary(3)|pancreas(1)	4						ATTTCTTATTGCAACATTGTA	0.323													10	56					0	0	0	0	A	94842665	A	A	94842665	3	1	154	1	0	0	0	0	1	0	0	0	16773	1319	46	4	1685	4	TTC37	5	94842665	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4768898	94842665	86072595	243	28090											
DMXL1	1657	broad.mit.edu	37	chr5	118469789	118469789	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttttctggaggagtttctGagcttgcccggattaattct	6	17	10	8	1	3	1	0	1	3	0	3	4	3	4	1	3	2	2	1	3	1	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:118469789G>C	uc003ksd.2	+	12	2351	c.2170G>C	c.(2170-2172)GAG>CAG	p.E724Q	DMXL1_uc010jcl.1_Missense_Mutation_p.E724Q|DMXL1_uc003ksc.1_Missense_Mutation_p.E724Q	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	724										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AGGAGTTTCTGAGCTTGCCCG	0.463													15	105					0	0	0	0	C	118469789	C	C	118469789	3	2	154	1	0	0	0	0	1	0	0	0	4616	1291	45	2	2216	2	DMXL1	5	118469789	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	23627124	118469789	62445471	244	28091											
FBN2	2201	broad.mit.edu	37	chr5	127647623	127647623	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtctgaagccttcacctccGggacacagggtgtaatattc	9	10	11	11	1	2	1	1	1	1	0	4	2	3	2	3	3	1	1	3	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:127647623G>C	uc003kuu.2	-	38	5341	c.4902C>G	c.(4900-4902)CCC>CCG	p.P1634P		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1634					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTTCACCTCCGGGACACAGGG	0.408													7	30					0	0	0	0	C	127647623	C	C	127647623	2	2	154	1	0	0	0	0	0	0	0	1	5735	1103	39	3		3	FBN2	5	127647623	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	9177834	127647623	53267637	245	28092											
FBN2	2201	broad.mit.edu	37	chr5	127648347	127648347	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctattgacaggggggcatgTctcacaggggtttccccagg	7	9	15	10	0	1	1	1	1	1	0	3	1	2	1	2	6	0	3	2	6	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:127648347T>A	uc003kuu.2	-	37	5297	c.4858A>T	c.(4858-4860)ACA>TCA	p.T1620S		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1620	TB 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGGGGGCATGTCTCACAGGGG	0.512													51	211					0	0	0	0	A	127648347	A	A	127648347	3	1	154	1	0	0	0	0	1	0	0	0	5735	1667	58	5	3996	5	FBN2	5	127648347	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	724	127648347	53266913	246	28093											
FBN2	2201	broad.mit.edu	37	chr5	127686626	127686626	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcacagcattcagatttcaGagtggctccattaatattca	12	12	8	9	0	3	2	3	0	0	2	4	2	4	2	1	2	1	3	1	2	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:127686626G>A	uc003kuu.2	-	21	3185	c.2746C>T	c.(2746-2748)CTG>TTG	p.L916L	FBN2_uc003kuv.2_Silent_p.L883L	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	916	TB 4.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCAGATTTCAGAGTGGCTCCA	0.567													6	68					0	0	0	0	A	127686626	A	A	127686626	2	1	154	1	0	0	0	0	0	0	0	1	5735	933	33	2		2	FBN2	5	127686626	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	38279	127686626	53228634	247	28094											
ADAMTS19	171019	broad.mit.edu	37	chr5	129039981	129039981	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcatcggaccgttagatgtaCcaacccaagaaagaagtgtg	14	8	10	9	2	1	3	1	0	0	3	2	4	1	4	3	1	2	2	3	1	6	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:129039981C>T	uc003kvb.1	+	21	3191	c.3191C>T	c.(3190-3192)ACC>ATC	p.T1064I	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1064	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GTTAGATGTACCAACCCAAGA	0.448													9	102					0	0	0	0	T	129039981	T	T	129039981	3	4	154	1	0	0	0	0	1	0	0	0	264	507	18	4	3273	4	ADAMTS19	5	129039981	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1353355	129039981	51875279	248	28095											
CHSY3	337876	broad.mit.edu	37	chr5	129520705	129520705	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaaaagaaagtacacattCtcgttcctctcatcggaagg	14	10	8	9	2	2	2	1	1	2	1	6	3	3	3	1	2	1	2	1	2	5	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:129520705C>G	uc003kvd.2	+	3	1870	c.1870C>G	c.(1870-1872)CTC>GTC	p.L624V		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	624	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		AGTACACATTCTCGTTCCTCT	0.348													13	46					0	0	0	0	G	129520705	G	G	129520705	3	3	154	1	0	0	0	0	1	0	0	0	3428	913	32	2	1880	2	CHSY3	5	129520705	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	480724	129520705	51394555	249	28096											
IL5	3567	broad.mit.edu	37	chr5	131879137	131879137	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacacgtaggcagctccaaGagctagcaaactcaaatgca	16	6	8	11	1	1	1	1	0	0	1	2	1	2	1	1	1	6	6	1	1	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:131879137G>C	uc003kxe.1	-	1	78	c.34C>G	c.(34-36)CTT>GTT	p.L12V		NM_000879	NP_000870	P05113	IL5_HUMAN	interleukin 5 precursor	12					immune response|inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of podosome assembly	extracellular space	cytokine activity|growth factor activity|interleukin-5 receptor binding				0		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Pranlukast(DB01411)	GCAGCTCCAAGAGCTAGCAAA	0.488													6	94					0	0	0	0	C	131879137	C	C	131879137	3	2	154	1	0	0	0	0	1	0	0	0	7738	942	33	2	386	2	IL5	5	131879137	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2358432	131879137	49036123	250	28097											
RAD50	10111	broad.mit.edu	37	chr5	131973799	131973799	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatacatagaaatacggtctGatgccgatgaaaatgtatca	17	10	8	6	2	2	3	1	2	1	1	2	4	2	3	1	1	3	1	1	1	8	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:131973799G>A	uc003kxi.2	+	23	3889	c.3502G>A	c.(3502-3504)GAT>AAT	p.D1168N	RAD50_uc003kxh.2_Missense_Mutation_p.D1029N	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	1168					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AATACGGTCTGATGCCGATGA	0.398								Homologous_recombination					9	46					0	0	0	0	A	131973799	A	A	131973799	3	1	154	1	0	0	0	0	1	0	0	0	13049	1290	45	2	3592	2	RAD50	5	131973799	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	94662	131973799	48941461	251	28098											
DDX46	9879	broad.mit.edu	37	chr5	134143458	134143458	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcattgatcaatatgacagaGatagcatcataaatgacttt	16	12	7	6	0	2	4	2	3	0	1	2	5	2	4	0	0	1	2	0	0	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:134143458G>A	uc003kzw.2	+	16	2143	c.1975G>A	c.(1975-1977)GAT>AAT	p.D659N	DDX46_uc003kzv.1_RNA	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	659	Helicase C-terminal.				mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATATGACAGAGATAGCATCAT	0.373													11	46					0	0	0	0	A	134143458	A	A	134143458	3	1	154	1	0	0	0	0	1	0	0	0	4381	942	33	2	2037	2	DDX46	5	134143458	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2169659	134143458	46771802	252	28099											
PSD2	84249	broad.mit.edu	37	chr5	139189229	139189229	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaggacccagatgtggccttCcatggcctcagccttggcct	7	9	11	14	0	1	1	1	0	0	1	2	2	2	2	6	4	1	0	6	4	1	2	rs34206173	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:139189229C>G	uc003leu.1	+	2	409	c.204C>G	c.(202-204)TTC>TTG	p.F68L		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	68					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTGGCCTTCCATGGCCTCA	0.637													12	67					0	0	0	0	G	139189229	G	G	139189229	3	3	154	1	0	0	0	0	1	0	0	0	12709	854	30	2	206	2	PSD2	5	139189229	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	5045771	139189229	41726031	253	28100											
PCDHA7	56141	broad.mit.edu	37	chr5	140215588	140215588	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggtgagcgcgcgcgatgcGggcgtgccgcctctgggcag	4	5	19	13	7	1	1	0	1	1	0	1	2	1	1	2	3	3	1	2	3	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:140215588G>C	uc003lhq.2	+	1	1620	c.1620G>C	c.(1618-1620)GCG>GCC	p.A540A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.A540A	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	540	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCGATGCGGGCGTGCCGC	0.682													36	155					0	0	0	0	C	140215588	C	C	140215588	2	2	154	1	0	0	0	0	0	0	0	1	11583	1103	39	3		3	PCDHA7	5	140215588	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1026359	140215588	40699672	254	28101											
PCDHB5	26167	broad.mit.edu	37	chr5	140516518	140516518	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cccacacctgcgcctcgcctCcctggtctccatcaacgcgg	5	7	8	21	4	2	0	1	0	1	0	5	0	3	0	6	2	2	0	6	2	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:140516518C>G	uc003liq.2	+	1	1719	c.1502C>G	c.(1501-1503)TCC>TGC	p.S501C		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	501	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCCTCGCCTCCCTGGTCTCC	0.657													34	131					0	0	0	0	G	140516518	G	G	140516518	3	3	154	1	0	0	0	0	1	0	0	0	11599	855	30	2	1504	2	PCDHB5	5	140516518	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	300930	140516518	40398742	255	28102											
PCDHB6	56130	broad.mit.edu	37	chr5	140531479	140531479	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcgaggcgctggtgcgcttGctggtgctggacgccaacga	6	7	17	11	5	0	0	0	0	0	0	0	3	0	1	1	4	5	4	1	4	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:140531479G>C	uc003lir.2	+	1	1641	c.1641G>C	c.(1639-1641)TTG>TTC	p.L547F	PCDHB6_uc011dah.1_Missense_Mutation_p.L411F	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	547	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTGCGCTTGCTGGTGCTGG	0.706													27	93					0	0	0	0	C	140531479	C	C	140531479	3	2	154	1	0	0	0	0	1	0	0	0	11600	1310	46	4	1643	4	PCDHB6	5	140531479	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	14961	140531479	40383781	256	28103											
PCDHB7	56129	broad.mit.edu	37	chr5	140554222	140554222	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgggccagaacgcctggctGtcgtaccagctgctcaaggc	7	7	13	14	3	1	1	1	0	0	1	3	1	1	1	3	3	4	4	3	3	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:140554222G>T	uc003lit.2	+	1	1980	c.1806G>T	c.(1804-1806)CTG>CTT	p.L602L		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	602	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGCCTGGCTGTCGTACCAGC	0.726													17	87					0.00121646	0.00230944	1	0	T	140554222	T	T	140554222	2	4	154	1	0	0	0	0	0	0	0	1	11601	1364	48	4		4	PCDHB7	5	140554222	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	22743	140554222	40361038	257	28104											
PCDHB12	56124	broad.mit.edu	37	chr5	140590115	140590115	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggctttgagcagcgaggcgCtggtgcgcgtgctggtgctg	3	9	19	10	5	0	1	0	1	0	0	0	2	0	1	0	4	5	5	0	4	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:140590115C>A	uc003liz.2	+	1	1825	c.1636C>A	c.(1636-1638)CTG>ATG	p.L546M	PCDHB12_uc011dak.1_Missense_Mutation_p.L209M	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	546	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGCGAGGCGCTGGTGCGCGT	0.697													19	76					0.00121646	0.00230944	1	0	A	140590115	A	A	140590115	3	1	154	1	0	0	0	0	1	0	0	0	11591	796	28	4	1638	4	PCDHB12	5	140590115	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	35893	140590115	40325145	258	28105											
PCDHGB3	56102	broad.mit.edu	37	chr5	140752193	140752193	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagttctccccacctacagCgaaaggactttgccttattc	9	11	8	13	1	1	0	0	0	1	0	3	3	1	2	4	2	3	1	4	2	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:140752193C>A	uc003ljw.1	+	1	2232	c.2232C>A	c.(2230-2232)AGC>AGA	p.S744R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.S744R|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	744	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCTACAGCGAAAGGACTT	0.512													7	59					0.00307968	0.00575353	1	0	A	140752193	A	A	140752193	3	1	154	1	0	0	0	0	1	0	0	0	11618	767	27	3	2234	3	PCDHGB3	5	140752193	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	162078	140752193	40163067	259	28106											
PCDHGA6	56109	broad.mit.edu	37	chr5	140755150	140755150	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gacaccctccagggggcgccCctgtcctcctacgtgtccat	5	8	10	18	2	0	0	0	0	0	0	4	1	4	0	7	2	1	0	7	2	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:140755150C>A	uc003ljy.1	+	1	1500	c.1500C>A	c.(1498-1500)CCC>CCA	p.P500P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.P500P	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	500	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGGGGCGCCCCTGTCCTCCT	0.592													26	141					3.73148e-12	8.59756e-12	1	0	A	140755150	A	A	140755150	2	1	154	1	0	0	0	0	0	0	0	1	11612	610	22	4		4	PCDHGA6	5	140755150	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2957	140755150	40160110	260	28107											
PCDHGA7	56108	broad.mit.edu	37	chr5	140764245	140764245	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgaccaaggtggtggcGgtggacaaagattcaggcca	10	7	16	8	1	1	2	1	1	0	1	1	3	1	3	2	7	0	0	2	7	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:140764245G>C	uc003lka.1	+	1	1779	c.1779G>C	c.(1777-1779)GCG>GCC	p.A593A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Silent_p.A593A	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	593	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGGTGGCGGTGGACAAAG	0.637													23	104					0	0	0	0	C	140764245	C	C	140764245	2	2	154	1	0	0	0	0	0	0	0	1	11613	1103	39	3		3	PCDHGA7	5	140764245	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	9095	140764245	40151015	261	28108											
PCDHGA7	56108	broad.mit.edu	37	chr5	140764339	140764339	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggttgggctgtacacgggcGaggtgcgcacggctcgggcc	4	6	19	12	6	0	0	0	0	0	0	1	1	0	0	1	6	2	5	1	6	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:140764339G>A	uc003lka.1	+	1	1873	c.1873G>A	c.(1873-1875)GAG>AAG	p.E625K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.E625K	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	625	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTACACGGGCGAGGTGCGCAC	0.647													8	63					0	0	0	0	A	140764339	A	A	140764339	3	1	154	1	0	0	0	0	1	0	0	0	11613	1059	37	1	1875	1	PCDHGA7	5	140764339	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	94	140764339	40150921	262	28109											
PCDHGB7	56099	broad.mit.edu	37	chr5	140798050	140798050	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgagaaacgcagagcgctcaCcacttggtactgaccgcctt	10	7	10	14	4	1	3	1	1	0	2	1	4	1	3	3	1	3	3	3	1	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:140798050C>G	uc003lkn.1	+	1	769	c.624C>G	c.(622-624)CAC>CAG	p.H208Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.H208Q|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	208	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGCGCTCACCACTTGGTAC	0.498													20	41					0	0	0	0	G	140798050	G	G	140798050	3	3	154	1	0	0	0	0	1	0	0	0	11622	506	18	4	626	4	PCDHGB7	5	140798050	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	33711	140798050	40117210	263	28110											
ARHGEF37	389337	broad.mit.edu	37	chr5	149006649	149006649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctcccagccgctccttcCagggtctgaacgccaggtgc	5	8	10	18	2	2	1	0	1	2	0	5	1	4	1	6	2	3	1	6	2	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:149006649C>T	uc003lra.1	+	11	1539	c.1475C>T	c.(1474-1476)CCA>CTA	p.P492L		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	492					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						CCGCTCCTTCCAGGGTCTGAA	0.522													23	78					0	0	0	0	T	149006649	T	T	149006649	3	4	154	1	0	0	0	0	1	0	0	0	906	594	21	4	1513	4	ARHGEF37	5	149006649	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	8208599	149006649	31908611	264	28111											
MED7	9443	broad.mit.edu	37	chr5	156566373	156566373	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagccttcttgaatattttCatccgtatattccttgatat	10	19	4	8	1	2	2	1	2	1	0	4	2	4	2	3	0	1	1	3	0	6	11			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:156566373C>T	uc010jik.2	-	2	462	c.70G>A	c.(70-72)GAA>AAA	p.E24K	MED7_uc003lwm.3_Missense_Mutation_p.E24K	NM_001100816	NP_001094286	O43513	MED7_HUMAN	mediator complex subunit 7	24					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	protein binding|transcription coactivator activity				0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGAATATTTTCATCCGTATAT	0.433													14	56					0	0	0	0	T	156566373	T	T	156566373	3	4	154	1	0	0	0	0	1	0	0	0	9505	835	29	2	635	2	MED7	5	156566373	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	7559724	156566373	24348887	265	28112											
C5orf40	408263	broad.mit.edu	37	chr5	156770191	156770191	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgaagcaggccagcagaatGgccatcagcacccaaaggga	14	3	13	11	0	1	2	1	1	0	1	1	3	1	3	3	3	3	3	3	3	3	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:156770191G>A	uc003lwu.2	-	2	542	c.354C>T	c.(352-354)GCC>GCT	p.A118A	CYFIP2_uc003lwq.2_Intron|CYFIP2_uc011ddn.1_Intron|CYFIP2_uc011ddo.1_Intron|CYFIP2_uc003lwr.2_Intron|CYFIP2_uc003lws.2_Intron|CYFIP2_uc003lwt.2_Intron|CYFIP2_uc011ddp.1_Intron	NM_001001343	NP_001001343	Q8TBE3	FNDC9_HUMAN	hypothetical protein LOC408263	118	Helical; (Potential).					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCAGCAGAATGGCCATCAGCA	0.592											OREG0016977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	51					0	0	0	0	A	156770191	A	A	156770191	2	1	154	1	0	0	0	0	0	0	0	1	2309	1335	47	4		4	C5orf40	5	156770191	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	203818	156770191	24145069	266	28113											
GABRA6	2559	broad.mit.edu	37	chr5	161119065	161119065	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttgctttgcattcgtcttCtctgcgcttatcgagttcgc	3	18	9	11	4	2	0	0	0	2	0	6	1	2	0	0	0	3	5	0	0	1	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:161119065C>T	uc003lyu.2	+	8	1283	c.945C>T	c.(943-945)TTC>TTT	p.F315F	GABRA6_uc003lyv.2_Silent_p.F86F	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	315	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CATTCGTCTTCTCTGCGCTTA	0.488										TCGA Ovarian(5;0.080)			10	92					0	0	0	0	T	161119065	T	T	161119065	2	4	154	1	0	0	0	0	0	0	0	1	6199	912	32	2		2	GABRA6	5	161119065	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4348874	161119065	19796195	267	28114											
LCP2	3937	broad.mit.edu	37	chr5	169714999	169714999	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccggagcttggggaacttctGgatgtcattttctgtcaggt	6	14	13	8	1	4	0	2	0	2	0	4	3	4	3	1	5	2	1	1	5	1	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:169714999G>C	uc003man.1	-	3	370	c.163C>G	c.(163-165)CAG>GAG	p.Q55E	LCP2_uc011det.1_5'UTR	NM_005565	NP_005556	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2	55	SAM.				immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		GGGAACTTCTGGATGTCATTT	0.527													11	31					0	0	0	0	C	169714999	C	C	169714999	3	2	154	1	0	0	0	0	1	0	0	0	8732	1357	47	4	1514	4	LCP2	5	169714999	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	8595934	169714999	11200261	268	28115											
STK10	6793	broad.mit.edu	37	chr5	171471924	171471924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtaggggaagaacttggCggccttgcttggggtggagg	7	9	19	6	1	0	1	0	0	0	1	0	3	0	3	1	8	2	2	1	8	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:171471924C>T	uc003mbo.1	-	19	3169	c.2869G>A	c.(2869-2871)GCC>ACC	p.A957T		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	957							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AAGAACTTGGCGGCCTTGCTT	0.597													11	52					0	0	0	0	T	171471924	T	T	171471924	3	4	154	1	0	0	0	0	1	0	0	0	15352	768	27	1	41	1	STK10	5	171471924	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1756925	171471924	9443336	269	28116											
CPEB4	80315	broad.mit.edu	37	chr5	173376544	173376544	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagttttcgtcgctttggccCtctgattgtggattggcctc	3	17	11	10	2	1	1	0	1	1	0	4	2	1	2	2	3	0	2	2	3	1	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:173376544C>G	uc003mcs.3	+	6	2896	c.1490C>G	c.(1489-1491)CCT>CGT	p.P497R	CPEB4_uc010jju.1_Missense_Mutation_p.P472R|CPEB4_uc010jjv.2_Missense_Mutation_p.P480R|CPEB4_uc011dfg.1_Missense_Mutation_p.P472R|CPEB4_uc003mct.3_Missense_Mutation_p.P107R|CPEB4_uc003mcu.3_Missense_Mutation_p.P90R	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	497	RRM 1.						nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CGCTTTGGCCCTCTGATTGTG	0.303													7	31					0	0	0	0	G	173376544	G	G	173376544	3	3	154	1	0	0	0	0	1	0	0	0	3818	681	24	4	1512	4	CPEB4	5	173376544	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1904620	173376544	7538716	270	28117											
GPRIN1	114787	broad.mit.edu	37	chr5	176026208	176026208	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttcccagggatccaagatCttcctttcttacagtcatgg	8	15	7	11	0	3	1	1	0	2	1	6	2	6	2	3	2	1	0	3	2	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:176026208C>T	uc003meo.1	-	2	803	c.628G>A	c.(628-630)GAT>AAT	p.D210N		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	210						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATCCAAGATCTTCCTTTCTT	0.507													7	82					0	0	0	0	T	176026208	T	T	176026208	3	4	154	1	0	0	0	0	1	0	0	0	6768	913	32	2	2402	2	GPRIN1	5	176026208	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2649664	176026208	4889052	271	28118											
GRM6	2916	broad.mit.edu	37	chr5	178416278	178416278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctctcacctgtgcatttgcGggtggaatcgtctgactggg	5	12	14	10	2	2	1	1	1	2	0	4	2	2	2	1	3	2	2	1	3	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:178416278G>A	uc003mjr.2	-	5	1320	c.1141C>T	c.(1141-1143)CGC>TGC	p.R381C	GRM6_uc010jla.1_5'UTR|GRM6_uc003mjs.1_5'UTR	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	381	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GTGCATTTGCGGGTGGAATCG	0.428													14	30					0	0	0	0	A	178416278	A	A	178416278	3	1	154	1	0	0	0	0	1	0	0	0	6840	1116	39	1	1516	1	GRM6	5	178416278	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2390070	178416278	2498982	272	28119											
FLT4	2324	broad.mit.edu	37	chr5	180046692	180046692	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattttcacggccacggtgtCacagctgctgcccttgtgga	6	11	11	13	2	2	0	2	0	0	0	2	1	2	1	2	3	3	2	2	3	0	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:180046692C>G	uc003mma.3	-	18	2699	c.2620G>C	c.(2620-2622)GAC>CAC	p.D874H	FLT4_uc003mlz.3_Missense_Mutation_p.D874H|FLT4_uc003mmb.1_Missense_Mutation_p.D407H	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	874	Cytoplasmic (Potential).|Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GCCACGGTGTCACAGCTGCTG	0.677									Congenital_Hereditary_Lymphedema				5	125					0	0	0	0	G	180046692	G	G	180046692	3	3	154	1	0	0	0	0	1	0	0	0	5976	826	29	2	1531	2	FLT4	5	180046692	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1630414	180046692	868568	273	28120											
BTNL9	153579	broad.mit.edu	37	chr5	180477289	180477289	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacatctgtggttgtccgagCgggagccctcagcaatgtgt	8	10	13	10	2	2	0	1	0	1	0	3	2	3	1	2	2	4	2	2	2	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr5:180477289C>G	uc003mmt.2	+	4	887	c.656C>G	c.(655-657)GCG>GGG	p.A219G	BTNL9_uc011dhi.1_Missense_Mutation_p.A150G	NM_152547	NP_689760	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9 precursor	219	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTGTCCGAGCGGGAGCCCTC	0.557													24	91					0	0	0	0	G	180477289	G	G	180477289	3	3	154	1	0	0	0	0	1	0	0	0	1573	768	27	3	666	3	BTNL9	5	180477289	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	430597	180477289	437971	274	28121											
KIF13A	63971	broad.mit.edu	37	chr6	17764532	17764532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accatcaaaatcttttccctCtgacactcccataaattctg	12	13	2	14	0	4	1	1	1	3	0	6	1	6	1	3	0	0	0	3	0	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:17764532C>T	uc003ncg.3	-	39	5332	c.5227G>A	c.(5227-5229)GAG>AAG	p.E1743K	KIF13A_uc003ncf.2_Missense_Mutation_p.E1695K|KIF13A_uc003nch.3_Missense_Mutation_p.E1708K|KIF13A_uc003nci.3_Missense_Mutation_p.E1695K|KIF13A_uc003nce.1_Missense_Mutation_p.E294K	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1743					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TCTTTTCCCTCTGACACTCCC	0.493													19	40					0	0	0	0	T	17764532	T	T	17764532	3	4	154	1	0	0	0	0	1	0	0	0	8313	922	32	2	219	2	KIF13A	6	17764532	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08		17764532	153350535	275	28122											
KIF13A	63971	broad.mit.edu	37	chr6	17817357	17817357	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcgggggagagctgctggcGgagttgctccagttcccgct	4	9	17	11	3	0	1	0	0	0	1	3	3	2	2	2	4	3	6	2	4	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:17817357G>A	uc003ncg.3	-	17	1999	c.1894C>T	c.(1894-1896)CGC>TGC	p.R632C	KIF13A_uc003ncf.2_Missense_Mutation_p.R632C|KIF13A_uc003nch.3_Missense_Mutation_p.R632C|KIF13A_uc003nci.3_Missense_Mutation_p.R632C|KIF13A_uc003ncj.2_Missense_Mutation_p.R308C	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	632	Potential.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			AGCTGCTGGCGGAGTTGCTCC	0.587													18	55					0	0	0	0	A	17817357	A	A	17817357	3	1	154	1	0	0	0	0	1	0	0	0	8313	1116	39	1	3640	1	KIF13A	6	17817357	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	52825	17817357	153297710	276	28123											
RNF144B	255488	broad.mit.edu	37	chr6	18459890	18459890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaagcagtgcccagtttgcCgggtttatatcgaacgcaat	10	12	10	9	3	0	0	0	0	0	0	1	1	0	0	2	1	4	4	2	1	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:18459890C>T	uc003ncs.2	+	6	893	c.589C>T	c.(589-591)CGG>TGG	p.R197W		NM_182757	NP_877434	Q7Z419	R144B_HUMAN	IBR domain containing 2	197	RING-type 2; degenerate.				apoptosis|positive regulation of anti-apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.00365)|Breast(50;0.0145)	all_hematologic(90;0.0536)	OV - Ovarian serous cystadenocarcinoma(7;0.00165)|all cancers(50;0.0102)|Epithelial(50;0.0105)			CCCAGTTTGCCGGGTTTATAT	0.468													5	74					0	0	0	0	T	18459890	T	T	18459890	3	4	154	1	0	0	0	0	1	0	0	0	13511	643	23	1	607	1	RNF144B	6	18459890	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	642533	18459890	152655177	277	28124											
FAM65B	9750	broad.mit.edu	37	chr6	24843287	24843287	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctgtggccattggcacctCtgcagatgtgagcctcttga	6	12	12	11	0	3	3	0	2	3	1	3	3	3	3	3	2	2	2	3	2	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:24843287C>G	uc003neo.1	-	14	1899	c.1723G>C	c.(1723-1725)GAG>CAG	p.E575Q	FAM65B_uc011djs.1_Missense_Mutation_p.E554Q|FAM65B_uc011dju.1_Missense_Mutation_p.E559Q|FAM65B_uc003nep.2_Missense_Mutation_p.E525Q|FAM65B_uc011djt.1_Missense_Mutation_p.E525Q	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	575					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						ATTGGCACCTCTGCAGATGTG	0.522													21	216					0	0	0	0	G	24843287	G	G	24843287	3	3	154	1	0	0	0	0	1	0	0	0	5632	922	32	2	1533	2	FAM65B	6	24843287	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6383397	24843287	146271780	278	28125											
FAM65B	9750	broad.mit.edu	37	chr6	24873906	24873906	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caaggccctgtagacttcttCcacccttttaggctgaggct	7	12	9	13	0	1	2	0	1	1	1	2	2	2	2	3	3	0	3	3	3	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:24873906C>G	uc003neo.1	-	3	399	c.223G>C	c.(223-225)GAA>CAA	p.E75Q	FAM65B_uc011djs.1_Missense_Mutation_p.E104Q|FAM65B_uc011dju.1_Missense_Mutation_p.E109Q|FAM65B_uc003nep.2_Missense_Mutation_p.E75Q|FAM65B_uc011djt.1_Missense_Mutation_p.E75Q	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	75	Involved in cell filopodia formation.				cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						TAGACTTCTTCCACCCTTTTA	0.448													15	72					0	0	0	0	G	24873906	G	G	24873906	3	3	154	1	0	0	0	0	1	0	0	0	5632	864	30	2	3077	2	FAM65B	6	24873906	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	30619	24873906	146241161	279	28126											
HIST1H3G	8355	broad.mit.edu	37	chr6	26271337	26271337	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcctcgcaggcctcctgcagGgccatcaccgcggaactctg	6	6	12	17	3	2	0	1	0	1	0	4	1	3	1	5	3	2	2	5	3	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:26271337G>T	uc003nhi.2	-	1	276	c.276C>A	c.(274-276)GCC>GCA	p.A92A	uc003nhj.2_5'Flank|HIST1H2BI_uc003nhk.2_5'Flank	NM_003534	NP_003525	P68431	H31_HUMAN	H3 histone family, member H	92					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						CCTCCTGCAGGGCCATCACCG	0.562													29	122					1.1423e-28	2.84041e-28	1	0	T	26271337	T	T	26271337	2	4	154	1	0	0	0	0	0	0	0	1	7200	1219	43	4		4	HIST1H3G	6	26271337	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1397431	26271337	144843730	280	28127											
OR2B6	26212	broad.mit.edu	37	chr6	27925414	27925414	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atttgtcggcctctccattaCtcagttatcatgcaccagag	9	13	7	12	1	3	1	2	0	1	1	5	1	3	1	3	1	2	2	3	1	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:27925414C>A	uc011dkx.1	+	1	396	c.396C>A	c.(394-396)TAC>TAA	p.Y132*		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTCTCCATTACTCAGTTATCA	0.493													14	156					1.5842e-08	3.40884e-08	1	0	A	27925414	A	A	27925414	4	1	154	1	0	0	0	0	0	1	0	0	11045	576	20	4	398	4	OR2B6	6	27925414	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1654077	27925414	143189653	281	28128											
ZSCAN16	80345	broad.mit.edu	37	chr6	28093331	28093331	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagtgcagtcctcacaggaGggaactctatagacaacact	15	7	9	10	0	2	1	1	0	1	1	3	3	3	3	1	2	3	1	1	2	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:28093331G>T	uc003nkm.2	+	2	210	c.110G>T	c.(109-111)AGG>ATG	p.R37M	uc010jqw.1_Intron|uc003nkk.1_Intron|uc003nkl.1_Intron|ZSCAN16_uc011dky.1_Missense_Mutation_p.R37M	NM_025231	NP_079507	Q9H4T2	ZSC16_HUMAN	zinc finger and SCAN domain containing 16	37					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)	1						CCTCACAGGAGGGAACTCTAT	0.532													8	251					0.00448238	0.00834748	1	0	T	28093331	T	T	28093331	3	4	154	1	0	0	0	0	1	0	0	0	18296	1000	35	4	112	4	ZSCAN16	6	28093331	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	167917	28093331	143021736	282	28129											
ZNF311	282890	broad.mit.edu	37	chr6	28971724	28971724	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaccctcctcttcttaccTcctgcatctttttactcagg	6	15	4	16	0	4	1	1	0	3	1	6	1	6	1	4	1	3	1	4	1	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:28971724T>G	uc003nlu.2	-	2	521	c.8A>C	c.(7-9)GAG>GCG	p.E3A	ZNF311_uc011dlk.1_5'UTR|ZNF311_uc003nlv.2_5'UTR	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						TCTTCTTACCTCCTGCATCTT	0.463													18	110					0	0	0	0	G	28971724	G	G	28971724	3	3	154	1	0	0	0	0	1	0	0	0	17901	1565	54	5	2016	5	ZNF311	6	28971724	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	878393	28971724	142143343	283	28130											
OR2H1	26716	broad.mit.edu	37	chr6	29430223	29430223	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcccaggcagtgctgaggaTtaactctgccacagcatgga	10	8	12	11	0	1	1	0	1	1	0	1	3	1	3	2	3	5	3	2	3	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:29430223T>A	uc003nmi.2	+	3	1120	c.677T>A	c.(676-678)ATT>AAT	p.I226N	OR2H1_uc003nmj.1_Missense_Mutation_p.I226N|OR2H1_uc010jri.1_Missense_Mutation_p.I148N	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTGCTGAGGATTAACTCTGCC	0.537													22	133					0	0	0	0	A	29430223	A	A	29430223	3	1	154	1	0	0	0	0	1	0	0	0	11055	1493	52	5	679	5	OR2H1	6	29430223	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	458499	29430223	141684844	284	28131											
MDC1	9656	broad.mit.edu	37	chr6	30673437	30673437	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagaggtgacaggctggtCtgtggaggtggaaggctgga	8	8	19	6	0	2	2	1	1	1	1	2	5	2	5	0	8	0	2	0	8	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:30673437C>A	uc003nrg.3	-	10	3963	c.3523G>T	c.(3523-3525)GAC>TAC	p.D1175Y	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.D782Y	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1175	Pro-rich.|Interaction with the PRKDC complex.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						ACAGGCTGGTCTGTGGAGGTG	0.552								Other_conserved_DNA_damage_response_genes					89	219					5.48297e-45	1.37113e-44	1	0	A	30673437	A	A	30673437	3	1	154	1	0	0	0	0	1	0	0	0	9456	913	32	2	2770	2	MDC1	6	30673437	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1243214	30673437	140441630	285	28132											
DDR1	780	broad.mit.edu	37	chr6	30863278	30863278	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acacccgcctgggccaaaccCaccaacacccagggtaagcc	12	2	8	19	1	0	0	0	0	0	0	0	0	0	0	7	2	3	1	7	2	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:30863278C>T	uc003nrr.2	+	13	1870	c.1611C>T	c.(1609-1611)CCC>CCT	p.P537P	DDR1_uc010jse.2_Intron|DDR1_uc003nrq.2_Intron|DDR1_uc003nrs.2_Silent_p.P537P|DDR1_uc003nrt.2_Intron|DDR1_uc011dms.1_Intron|DDR1_uc003nru.2_Intron|DDR1_uc003nrv.2_Silent_p.P537P|DDR1_uc003nrw.1_Missense_Mutation_p.P309L|DDR1_uc003nry.1_Intron|DDR1_uc003nrx.1_Intron|DDR1_uc003nrz.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	537	Gly/Pro-rich.|Cytoplasmic (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	GGGCCAAACCCACCAACACCC	0.677													29	107					0	0	0	0	T	30863278	T	T	30863278	2	4	154	1	0	0	0	0	0	0	0	1	4353	581	21	4		4	DDR1	6	30863278	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	189841	30863278	140251789	286	28133											
GTF2H4	2968	broad.mit.edu	37	chr6	30878470	30878470	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctggtctgatgacacaagtCagctgggaccagacaagcat	12	7	11	11	0	2	3	1	2	1	1	2	4	2	4	2	2	2	2	2	2	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:30878470C>T	uc003nsa.1	+	5	610	c.403C>T	c.(403-405)CAG>TAG	p.Q135*	GTF2H4_uc010jsf.2_Nonsense_Mutation_p.Q135*|GTF2H4_uc011dmv.1_Nonsense_Mutation_p.Q79*|GTF2H4_uc003nsb.1_5'UTR|GTF2H4_uc011dmw.1_Nonsense_Mutation_p.Q141*	NM_001517	NP_001508	Q92759	TF2H4_HUMAN	general transcription factor IIH, polypeptide 4,	135					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3						TGACACAAGTCAGCTGGGACC	0.478								NER					4	21					0	0	0	0	T	30878470	T	T	30878470	4	4	154	1	0	0	0	0	0	1	0	0	6904	827	29	2	417	2	GTF2H4	6	30878470	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	15192	30878470	140236597	287	28134											
CCHCR1	54535	broad.mit.edu	37	chr6	31112662	31112662	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acccatttccctctcgacacCttgcccgtagagttcctgct	6	12	6	17	2	1	1	0	0	1	1	4	2	3	1	5	0	2	3	5	0	1	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:31112662C>G	uc003nsr.3	-	14	1921	c.1798G>C	c.(1798-1800)GCC>CCC	p.A600P	CCHCR1_uc011dne.1_Missense_Mutation_p.A600P|CCHCR1_uc003nsq.3_Missense_Mutation_p.A653P|CCHCR1_uc003nsp.3_Missense_Mutation_p.A689P|CCHCR1_uc010jsk.1_Missense_Mutation_p.G600R	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	600	Potential.				cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						CTCTCGACACCTTGCCCGTAG	0.627													26	121					0	0	0	0	G	31112662	G	G	31112662	3	3	154	1	0	0	0	0	1	0	0	0	2890	695	24	4	570	4	CCHCR1	6	31112662	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	234192	31112662	140002405	288	28135											
TNXB	7148	broad.mit.edu	37	chr6	32035750	32035750	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctgtggggctgggggtctCttcctctgcagctgagaagg	4	12	16	9	0	3	1	0	1	3	1	5	2	4	1	1	5	2	3	1	5	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:32035750C>G	uc003nzl.2	-	18	6434	c.6232G>C	c.(6232-6234)GAG>CAG	p.E2078Q		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CTGGGGGTCTCTTCCTCTGCA	0.632													12	39					0	0	0	0	G	32035750	G	G	32035750	3	3	154	1	0	0	0	0	1	0	0	0	16412	922	32	2	8589	2	TNXB	6	32035750	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	923088	32035750	139079317	289	28136											
TNXB	7148	broad.mit.edu	37	chr6	32037926	32037926	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtgccgtcggcagtgagAgggccatggcgcttcttgcc	4	9	17	11	3	1	1	0	1	1	1	2	2	1	1	3	4	2	2	3	4	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:32037926A>C	uc003nzl.2	-	14	5458	c.5256T>G	c.(5254-5256)CCT>CCG	p.P1752P		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1834	Fibronectin type-III 10.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CGGCAGTGAGAGGGCCATGGC	0.642													9	19					0	0	0	0	C	32037926	C	C	32037926	2	2	154	1	0	0	0	0	0	0	0	1	16412	291	11	5		5	TNXB	6	32037926	Silent	SNP	A	TCGA-CR-7388-01A-11D-2012-08	2176	32037926	139077141	290	28137											
TCP11	6954	broad.mit.edu	37	chr6	35087972	35087972	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaacaaggatttggttatgCgtttcagtttatctacaaat	12	15	7	7	1	2	0	1	0	1	0	2	1	2	1	1	2	3	3	1	2	6	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:35087972C>T	uc003okd.2	-	8	1299	c.1118G>A	c.(1117-1119)CGC>CAC	p.R373H	TCP11_uc003ojz.1_Missense_Mutation_p.R298H|TCP11_uc003oka.2_Missense_Mutation_p.R298H|TCP11_uc003okb.2_Missense_Mutation_p.R297H|TCP11_uc003okc.2_Missense_Mutation_p.R297H|TCP11_uc011dsu.1_Missense_Mutation_p.R355H|TCP11_uc011dsv.1_Missense_Mutation_p.R322H|TCP11_uc011dsw.1_Missense_Mutation_p.R327H	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	360					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						TTTGGTTATGCGTTTCAGTTT	0.438													4	24					0	0	0	0	T	35087972	T	T	35087972	3	4	154	1	0	0	0	0	1	0	0	0	15779	768	27	1	444	1	TCP11	6	35087972	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3050046	35087972	136027095	291	28138											
CPNE5	57699	broad.mit.edu	37	chr6	36767803	36767803	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccacaatgaacttgcgcacGaagtcaggattgagcgtgtt	11	10	11	9	3	1	2	1	2	0	0	2	4	2	3	1	1	3	2	1	1	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:36767803G>A	uc003omr.1	-	4	295	c.228C>T	c.(226-228)TTC>TTT	p.F76F	CPNE5_uc003oms.1_Silent_p.F38F	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V	76	C2 1.									skin(1)	1						ACTTGCGCACGAAGTCAGGAT	0.552													9	34					0	0	0	0	A	36767803	A	A	36767803	2	1	154	1	0	0	0	0	0	0	0	1	3830	1049	37	1		1	CPNE5	6	36767803	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1679831	36767803	134347264	292	28139											
GCM1	8521	broad.mit.edu	37	chr6	52993189	52993189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtatgcaggagactggaCgtagctgttaaaatccacat	13	10	11	7	1	0	1	0	0	0	1	1	3	1	2	1	3	2	5	1	3	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:52993189C>T	uc003pbp.2	-	6	1335	c.1126G>A	c.(1126-1128)GTC>ATC	p.V376I		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	376						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					GGAGACTGGACGTAGCTGTTA	0.478													14	165					0	0	0	0	T	52993189	T	T	52993189	3	4	154	1	0	0	0	0	1	0	0	0	6332	536	19	1	188	1	GCM1	6	52993189	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	16225386	52993189	118121878	293	28140											
COL21A1	81578	broad.mit.edu	37	chr6	56044743	56044743	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcctgaatcatagcttccGagaggaatctccagcacagg	11	9	9	12	1	3	2	1	1	2	1	6	4	4	3	3	2	2	2	3	2	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:56044743G>A	uc003pcs.2	-	3	505	c.273C>T	c.(271-273)CTC>CTT	p.L91L	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Silent_p.L91L|COL21A1_uc003pcu.1_Silent_p.L91L	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	91	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CATAGCTTCCGAGAGGAATCT	0.453													4	14					0	0	0	0	A	56044743	A	A	56044743	2	1	154	1	0	0	0	0	0	0	0	1	3695	1045	37	1		1	COL21A1	6	56044743	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3051554	56044743	115070324	294	28141											
ZNF451	26036	broad.mit.edu	37	chr6	57013446	57013446	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaactattcaaaaagtttaGacatggagaaaggagttgag	18	10	10	3	0	1	3	1	1	0	2	1	5	1	4	0	2	1	2	0	2	7	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:57013446G>C	uc003pdm.1	+	10	2787	c.2563G>C	c.(2563-2565)GAC>CAC	p.D855H	ZNF451_uc003pdl.2_Missense_Mutation_p.D855H|ZNF451_uc003pdn.1_Missense_Mutation_p.D855H|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.D855H	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	855					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AAAAAGTTTAGACATGGAGAA	0.333													4	33					0	0	0	0	C	57013446	C	C	57013446	3	2	154	1	0	0	0	0	1	0	0	0	17989	942	33	2	2601	2	ZNF451	6	57013446	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	968703	57013446	114101621	295	28142											
PRIM2	5558	broad.mit.edu	37	chr6	57512590	57512590	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaaccagaaactcctcaacCcaaaccaagtgtccagaaaa	18	4	4	15	0	1	2	1	0	0	2	3	2	3	2	6	0	4	0	6	0	7	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:57512590C>G	uc003pdx.2	+	15	1505	c.1418C>G	c.(1417-1419)CCC>CGC	p.P473R		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	473					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		ACTCCTCAACCCAAACCAAGT	0.393													16	364					0	0	0	0	G	57512590	G	G	57512590	3	3	154	1	0	0	0	0	1	0	0	0	12553	623	22	4	1468	4	PRIM2	6	57512590	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	499144	57512590	113602477	296	28143											
PHF3	23469	broad.mit.edu	37	chr6	64394442	64394442	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaaagaaaaatgaagctttGatggaatgtaaagccaagcc	19	7	10	5	0	0	3	0	2	0	1	0	5	0	4	2	1	3	2	2	1	9	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:64394442G>C	uc003pep.1	+	3	845	c.819G>C	c.(817-819)TTG>TTC	p.L273F	PHF3_uc010kaf.1_Missense_Mutation_p.L273F|PHF3_uc003pem.2_Missense_Mutation_p.L226F|PHF3_uc010kag.1_Missense_Mutation_p.L185F|PHF3_uc010kah.1_Missense_Mutation_p.L87F|PHF3_uc003pen.2_Missense_Mutation_p.L185F|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.2_Missense_Mutation_p.L273F	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	273					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			ATGAAGCTTTGATGGAATGTA	0.348													5	63					0	0	0	0	C	64394442	C	C	64394442	3	2	154	1	0	0	0	0	1	0	0	0	11891	1281	45	2	829	2	PHF3	6	64394442	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	6881852	64394442	106720625	297	28144											
BAI3	577	broad.mit.edu	37	chr6	69949029	69949029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggctaggtacatacgctctGagagatccataatactaatt	13	12	8	8	1	1	2	0	1	1	1	2	3	2	2	1	2	3	3	1	2	6	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:69949029G>C	uc003pev.3	+	20	3173	c.2725G>C	c.(2725-2727)GAG>CAG	p.E909Q	BAI3_uc010kak.2_Missense_Mutation_p.E909Q|BAI3_uc011dxx.1_Missense_Mutation_p.E115Q|BAI3_uc003pex.1_Missense_Mutation_p.E39Q	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	909	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CATACGCTCTGAGAGATCCAT	0.373													12	142					0	0	0	0	C	69949029	C	C	69949029	3	2	154	1	0	0	0	0	1	0	0	0	1302	1291	45	2	2795	2	BAI3	6	69949029	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5554587	69949029	101166038	298	28145											
KHDC1	80759	broad.mit.edu	37	chr6	73919739	73919739	+	RNA	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattggatcatgaaagttttCaggcagggtctaccacggct	10	11	11	9	1	3	1	2	1	1	0	3	2	3	2	1	4	1	3	1	4	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:73919739C>G	uc011dyl.1	-	8		c.1354G>C						Q4VXA5	KHDC1_HUMAN	Homo sapiens cDNA FLJ30329 fis, clone BRACE2007201.							integral to membrane	RNA binding			skin(1)	1						TGAAAGTTTTCAGGCAGGGTC	0.527													4	29					0	0	0	0	G	73919739	G	G	73919739	1	3	154	0	1	0	0	0	0	0	0	0	8183	841	29	2		2	KHDC1	6	73919739	RNA	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3970710	73919739	97195328	299	28146											
SIM1	6492	broad.mit.edu	37	chr6	100868714	100868714	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gactttgagctggagagccgGgatttggccccctttctgtt	5	13	13	10	1	1	2	0	1	1	1	1	5	1	3	3	3	2	2	3	3	0	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:100868714G>A	uc003pqj.3	-	9	1326	c.1119C>T	c.(1117-1119)TCC>TCT	p.S373S	SIM1_uc010kcu.2_Silent_p.S373S	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	373	Single-minded C-terminal.|Nuclear localization signal (By similarity).				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TGGAGAGCCGGGATTTGGCCC	0.507													11	37					0	0	0	0	A	100868714	A	A	100868714	2	1	154	1	0	0	0	0	0	0	0	1	14388	1219	43	4		4	SIM1	6	100868714	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	26948975	100868714	70246353	300	28147											
LAMA2	3908	broad.mit.edu	37	chr6	129513899	129513899	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctccccagcaggacgacttGgactcacctcagcagatcag	10	6	10	15	1	3	1	3	0	0	1	4	4	4	3	3	2	2	3	3	2	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:129513899G>T	uc003qbn.2	+	12	1788	c.1683G>T	c.(1681-1683)TTG>TTT	p.L561F	LAMA2_uc003qbo.2_Missense_Mutation_p.L561F	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	561	Laminin IV type A 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AGGACGACTTGGACTCACCTC	0.557													7	42					0.00198382	0.003734	1	0	T	129513899	T	T	129513899	3	4	154	1	0	0	0	0	1	0	0	0	8646	1339	47	4	1729	4	LAMA2	6	129513899	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	28645185	129513899	41601168	301	28148											
EPB41L2	2037	broad.mit.edu	37	chr6	131222264	131222264	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagagcatgagtcacaaaaGagcagggcaggcggccagag	14	2	17	8	1	1	4	1	1	0	3	1	5	1	4	1	4	2	3	1	4	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:131222264G>C	uc003qch.2	-	7	1168	c.986C>G	c.(985-987)TCT>TGT	p.S329C	EPB41L2_uc003qcg.1_Missense_Mutation_p.S329C|EPB41L2_uc011eby.1_Missense_Mutation_p.S329C|EPB41L2_uc003qci.2_Missense_Mutation_p.S329C|EPB41L2_uc010kfk.2_Missense_Mutation_p.S329C|EPB41L2_uc010kfl.1_Missense_Mutation_p.S329C	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	329	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		AGTCACAAAAGAGCAGGGCAG	0.547													13	78					0	0	0	0	C	131222264	C	C	131222264	3	2	154	1	0	0	0	0	1	0	0	0	5177	942	33	2	2083	2	EPB41L2	6	131222264	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1708365	131222264	39892803	302	28149											
C6orf97	80129	broad.mit.edu	37	chr6	151939225	151939225	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttacctgtgcctgcctcaaAgatgtgactactgggcaaga	10	10	11	10	0	1	3	1	1	0	2	1	3	1	3	3	1	4	2	3	1	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:151939225A>G	uc003qol.2	+	11	2180	c.2091A>G	c.(2089-2091)AAA>AAG	p.K697K		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	697											0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		CCTGCCTCAAAGATGTGACTA	0.463													11	58					0	0	0	0	G	151939225	G	G	151939225	2	3	154	1	0	0	0	0	0	0	0	1	2385	69	3	5		5	C6orf97	6	151939225	Silent	SNP	A	TCGA-CR-7388-01A-11D-2012-08	20716961	151939225	19175842	303	28150											
SYNE1	23345	broad.mit.edu	37	chr6	152786534	152786534	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acactcctcacttctactgaGagattcctccactgagcggt	9	11	7	14	1	2	3	1	2	1	1	5	4	5	3	3	1	2	0	3	1	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:152786534G>C	uc010kiw.2	-	18	2393	c.1791C>G	c.(1789-1791)CTC>CTG	p.L597L	SYNE1_uc003qot.3_Silent_p.L604L|SYNE1_uc003qou.3_Silent_p.L597L|SYNE1_uc010kjb.1_Silent_p.L580L|SYNE1_uc003qpa.1_Silent_p.L597L|SYNE1_uc003qow.2_5'Flank|SYNE1_uc003qox.1_Silent_p.L113L|SYNE1_uc003qoz.2_Silent_p.L29L|SYNE1_uc003qoy.2_Silent_p.L164L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	597	Cytoplasmic (Potential).|HAT 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTCTACTGAGAGATTCCTCC	0.443										HNSCC(10;0.0054)			8	41					0	0	0	0	C	152786534	C	C	152786534	2	2	154	1	0	0	0	0	0	0	0	1	15511	929	33	2		2	SYNE1	6	152786534	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	847309	152786534	18328533	304	28151											
SYNE1	23345	broad.mit.edu	37	chr6	152826448	152826448	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctccaagtccaccaattcCggtcgaatggcatgaataac	12	9	8	12	2	1	1	0	1	1	0	5	2	3	1	4	2	1	1	4	2	5	2	rs141368652		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:152826448C>A	uc010kiw.2	-	9	1268	c.666G>T	c.(664-666)CCG>CCT	p.P222P	SYNE1_uc003qot.3_Silent_p.P229P|SYNE1_uc003qou.3_Silent_p.P222P|SYNE1_uc010kjb.1_Silent_p.P222P|SYNE1_uc003qpa.1_Silent_p.P222P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	222	Actin-binding.|CH 2.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCACCAATTCCGGTCGAATGG	0.448										HNSCC(10;0.0054)			12	42					1.08611e-07	2.29492e-07	1	0	A	152826448	A	A	152826448	2	1	154	1	0	0	0	0	0	0	0	1	15511	639	23	3		3	SYNE1	6	152826448	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	39914	152826448	18288619	305	28152											
CNKSR3	154043	broad.mit.edu	37	chr6	154763316	154763316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgcgggaggtgttgccatCgtaagcgggacttttccgtc	5	12	14	10	4	0	0	0	0	0	0	3	2	1	2	2	3	3	2	2	3	1	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:154763316C>T	uc003qpy.2	-	3	830	c.325G>A	c.(325-327)GAT>AAT	p.D109N		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	109	CRIC.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		GTGTTGCCATCGTAAGCGGGA	0.542													6	45					0	0	0	0	T	154763316	T	T	154763316	3	4	154	1	0	0	0	0	1	0	0	0	3623	884	31	1	1386	1	CNKSR3	6	154763316	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1936868	154763316	16351751	306	28153											
SYNJ2	8871	broad.mit.edu	37	chr6	158516991	158516991	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctccagggcctcacttacaaTagcagtgacagcccctctgg	9	8	9	15	0	2	1	1	1	1	0	3	1	3	1	4	2	3	1	4	2	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:158516991T>C	uc003qqx.1	+	27	4161	c.4086T>C	c.(4084-4086)AAT>AAC	p.N1362N	SYNJ2_uc003qqy.1_Silent_p.N1075N|SYNJ2_uc003qqz.1_Silent_p.N979N|SYNJ2_uc003qra.1_Silent_p.N705N|SYNJ2_uc010kjp.1_Silent_p.N245N	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1362	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		TCACTTACAATAGCAGTGACA	0.622													8	31					0	0	0	0	C	158516991	C	C	158516991	2	2	154	1	0	0	0	0	0	0	0	1	15519	1403	49	5		5	SYNJ2	6	158516991	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	3753675	158516991	12598076	307	28154											
MAS1	4142	broad.mit.edu	37	chr6	160328648	160328648	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggaagaacacgtgggctTcccattcctccaagctttac	9	10	8	14	2	0	1	0	0	0	1	4	2	4	2	4	2	3	2	4	2	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:160328648T>G	uc003qsz.2	+	1	675	c.661T>G	c.(661-663)TCC>GCC	p.S221A		NM_002377	NP_002368	P04201	MAS_HUMAN	MAS1 oncogene	221	Cytoplasmic (Potential).				anatomical structure morphogenesis|cell proliferation|protein kinase C signaling cascade	integral to plasma membrane	angiotensin type II receptor activity			ovary(2)|lung(2)	4		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.6e-06)		CACGTGGGCTTCCCATTCCTC	0.483													7	39					0	0	0	0	G	160328648	G	G	160328648	3	3	154	1	0	0	0	0	1	0	0	0	9373	1783	62	5	663	5	MAS1	6	160328648	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1811657	160328648	10786419	308	28155											
PLG	5340	broad.mit.edu	37	chr6	161127476	161127476	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgactatgtgaatacccaGggggcttcactgttcagtgt	9	12	12	8	0	2	2	2	2	0	0	2	3	2	2	1	2	1	2	1	2	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr6:161127476G>C	uc003qtm.3	+	2	150	c.87G>C	c.(85-87)CAG>CAC	p.Q29H		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	29	PAN.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TGAATACCCAGGGGGCTTCAC	0.458													22	105					0	0	0	0	C	161127476	C	C	161127476	3	2	154	1	0	0	0	0	1	0	0	0	12141	991	35	4	93	4	PLG	6	161127476	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	798828	161127476	9987591	309	28156											
MAD1L1	8379	broad.mit.edu	37	chr7	2259027	2259027	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgactccaggcgcttcaccCgcatctcctggtccatcacg	6	8	8	19	4	3	0	2	0	1	0	6	1	5	0	5	2	0	2	5	2	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:2259027C>A	uc003slh.1	-	6	802	c.536G>T	c.(535-537)CGG>CTG	p.R179L	MAD1L1_uc003slf.1_Missense_Mutation_p.R179L|MAD1L1_uc003slg.1_Missense_Mutation_p.R179L|MAD1L1_uc010ksh.1_Missense_Mutation_p.R179L|MAD1L1_uc003sli.1_Missense_Mutation_p.R87L|MAD1L1_uc010ksi.1_Missense_Mutation_p.R132L|MAD1L1_uc010ksj.2_Missense_Mutation_p.R179L	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	179	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		GCGCTTCACCCGCATCTCCTG	0.632													6	14					2.0095e-06	4.12217e-06	1	0	A	2259027	A	A	2259027	3	1	154	1	0	0	0	0	1	0	0	0	9198	652	23	3	1676	3	MAD1L1	7	2259027	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08		2259027	156879636	310	28157											
FTSJ2	29960	broad.mit.edu	37	chr7	2275158	2275158	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccagggggaatatgtgaaGaagatctaccccaagcacga	14	7	11	9	1	1	3	0	1	1	2	2	5	2	4	3	2	2	1	3	2	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:2275158G>C	uc003slm.2	-	3	369	c.340C>G	c.(340-342)CTT>GTT	p.L114V	MAD1L1_uc003slh.1_5'Flank|MAD1L1_uc003slf.1_5'Flank|MAD1L1_uc003slg.1_5'Flank|MAD1L1_uc010ksh.1_5'Flank|MAD1L1_uc003sli.1_5'Flank|MAD1L1_uc010ksi.1_5'Flank|MAD1L1_uc010ksj.2_5'Flank|FTSJ2_uc003slk.2_5'UTR|FTSJ2_uc003sll.2_5'UTR|FTSJ2_uc003sln.2_RNA|FTSJ2_uc003slo.2_5'UTR	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	FtsJ homolog 2	114					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		AATATGTGAAGAAGATCTACC	0.468													10	51					0	0	0	0	C	2275158	C	C	2275158	3	2	154	1	0	0	0	0	1	0	0	0	6122	942	33	2	404	2	FTSJ2	7	2275158	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	16131	2275158	156863505	311	28158											
SNX8	29886	broad.mit.edu	37	chr7	2297046	2297046	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccacggactccggctcgcggTtctgcgcggtggcgctcatc	3	8	14	16	7	2	0	1	0	1	0	5	1	3	1	2	5	1	3	2	5	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:2297046T>C	uc003slw.2	-	9	1131	c.1088A>G	c.(1087-1089)AAC>AGC	p.N363S		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	363					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CGGCTCGCGGTTCTGCGCGGT	0.677													5	17					0	0	0	0	C	2297046	C	C	2297046	3	2	154	1	0	0	0	0	1	0	0	0	14972	1725	60	5	321	5	SNX8	7	2297046	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	21888	2297046	156841617	312	28159											
FOXK1	221937	broad.mit.edu	37	chr7	4796623	4796623	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatatctctgcttccctgcAgaattctatccggcacaacc	10	11	6	14	1	2	1	0	0	2	1	5	2	4	1	3	1	3	3	3	1	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:4796623A>G	uc003snc.1	+	5	1061	c.1051_splice	c.e5-2	p.N351_splice	FOXK1_uc003sna.1_Splice_Site_p.N188_splice	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1						cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		GCTTCCCTGCAGAATTCTATC	0.532													7	42					0	0	0	0	G	4796623	G	G	4796623	5	3	154	1	0	0	0	0	0	0	1	0	6048	202	7	5	1067	5	FOXK1	7	4796623	Splice_Site	SNP	A	TCGA-CR-7388-01A-11D-2012-08	2499577	4796623	154342040	313	28160											
RAC1	5879	broad.mit.edu	37	chr7	6441557	6441557	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcatcctagtgggaactaAacttgatcttagggatgata	13	12	9	7	0	2	2	1	2	1	0	3	4	3	4	1	2	2	0	1	2	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:6441557A>G	uc003spx.2	+	5	588	c.347A>G	c.(346-348)AAA>AGA	p.K116R	RAC1_uc003spw.2_Missense_Mutation_p.K135R	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	116	GTP (By similarity).				actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	GTGGGAACTAAACTTGATCTT	0.488													4	81					0	0	0	0	G	6441557	G	G	6441557	3	3	154	1	0	0	0	0	1	0	0	0	13039	14	1	5	426	5	RAC1	7	6441557	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	1644934	6441557	152697106	314	28161											
MEOX2	4223	broad.mit.edu	37	chr7	15725621	15725621	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cggccccagtcggggtgctgGagcccaagctggaagagttg	7	6	17	11	2	0	1	0	0	0	1	1	3	0	3	3	5	3	3	3	5	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:15725621G>C	uc003stc.2	-	1	688	c.407C>G	c.(406-408)TCC>TGC	p.S136C	MEOX2_uc011jxw.1_Missense_Mutation_p.S136C	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	136					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S136F(1)		ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		CGGGGTGCTGGAGCCCAAGCT	0.716													8	68					0	0	0	0	C	15725621	C	C	15725621	3	2	154	1	0	0	0	0	1	0	0	0	9527	1174	41	2	519	2	MEOX2	7	15725621	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	9284064	15725621	143413042	315	28162											
MACC1	346389	broad.mit.edu	37	chr7	20198324	20198324	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgccttcagggttacccCatagttgctaaagttcaatg	10	12	8	11	0	2	0	2	0	0	0	2	0	2	0	3	1	3	4	3	1	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:20198324C>A	uc003sus.3	-	5	1969	c.1660G>T	c.(1660-1662)GGG>TGG	p.G554W	MACC1_uc010kug.2_Missense_Mutation_p.G554W	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	554	SH3.				positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						AGGGTTACCCCATAGTTGCTA	0.378													6	142					0.00116845	0.00222308	1	0	A	20198324	A	A	20198324	3	1	154	1	0	0	0	0	1	0	0	0	9194	594	21	4	910	4	MACC1	7	20198324	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4472703	20198324	138940339	316	28163											
DNAH11	8701	broad.mit.edu	37	chr7	21779240	21779240	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atccataactgccagtatgtCgcctgcatgaatccgatggt	10	11	9	11	2	0	1	0	1	0	0	3	2	2	1	4	1	3	2	4	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:21779240C>T	uc003svc.2	+	49	7915	c.7884C>T	c.(7882-7884)GTC>GTT	p.V2628V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2628	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GCCAGTATGTCGCCTGCATGA	0.423									Kartagener_syndrome				13	65					0	0	0	0	T	21779240	T	T	21779240	2	4	154	1	0	0	0	0	0	0	0	1	4621	871	31	1		1	DNAH11	7	21779240	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1580916	21779240	137359423	317	28164											
CPVL	54504	broad.mit.edu	37	chr7	29111998	29111998	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcacagggttgagggaatgGatgaggtgtgcaatggctgg	9	9	18	5	0	1	2	1	2	0	0	1	4	1	4	0	6	1	3	0	6	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:29111998G>A	uc003szv.2	-	8	770	c.651C>T	c.(649-651)ATC>ATT	p.I217I	CPVL_uc003szw.2_Silent_p.I217I|CPVL_uc003szx.2_Silent_p.I217I	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	217					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						TGAGGGAATGGATGAGGTGTG	0.433													13	35					0	0	0	0	A	29111998	A	A	29111998	2	1	154	1	0	0	0	0	0	0	0	1	3850	1164	41	2		2	CPVL	7	29111998	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	7332758	29111998	130026665	318	28165											
SCRN1	9805	broad.mit.edu	37	chr7	29980412	29980412	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtccaccaaccttggctctGagcgtaactcctgagttccg	7	10	9	15	3	1	2	0	2	1	0	4	2	4	2	5	1	3	3	5	1	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:29980412G>C	uc010kvp.2	-	4	829	c.625C>G	c.(625-627)CAG>GAG	p.Q209E	SCRN1_uc011jzy.1_Missense_Mutation_p.Q141E|SCRN1_uc003tak.2_Missense_Mutation_p.Q209E|SCRN1_uc011jzz.1_Missense_Mutation_p.Q209E|SCRN1_uc011kaa.1_Missense_Mutation_p.Q229E|SCRN1_uc011jzw.1_Intron|SCRN1_uc011jzx.1_Missense_Mutation_p.Q32E	NM_001145515	NP_001138987	Q12765	SCRN1_HUMAN	secernin 1 isoform c	209					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			ovary(2)	2						CCTTGGCTCTGAGCGTAACTC	0.527													18	162					0	0	0	0	C	29980412	C	C	29980412	3	2	154	1	0	0	0	0	1	0	0	0	14003	1299	45	2	635	2	SCRN1	7	29980412	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	868414	29980412	129158251	319	28166											
KBTBD2	25948	broad.mit.edu	37	chr7	32908969	32908969	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttccccactatacaggtggTagtgcaaccatttctccatc	9	12	6	14	0	1	0	0	0	1	0	4	0	2	0	4	2	3	2	4	2	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:32908969T>C	uc003tdb.2	-	4	2519	c.1860A>G	c.(1858-1860)CTA>CTG	p.L620L	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	620											0			GBM - Glioblastoma multiforme(11;0.0499)			ATACAGGTGGTAGTGCAACCA	0.423													8	58					0	0	0	0	C	32908969	C	C	32908969	2	2	154	1	0	0	0	0	0	0	0	1	8032	1625	57	5		5	KBTBD2	7	32908969	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	2928557	32908969	126229694	320	28167											
ANLN	54443	broad.mit.edu	37	chr7	36461541	36461541	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcttaactgctgtgttgatGaagaacatggaaaagggtcc	12	11	11	7	0	1	3	0	2	1	1	2	4	2	4	1	2	3	2	1	2	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:36461541G>C	uc003tff.2	+	13	2443	c.2239G>C	c.(2239-2241)GAA>CAA	p.E747Q	ANLN_uc011kaz.1_Missense_Mutation_p.E659Q|ANLN_uc003tfg.2_Missense_Mutation_p.E710Q|ANLN_uc010kxe.2_Missense_Mutation_p.E709Q	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	747	Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						CTGTGTTGATGAAGAACATGG	0.393													4	48					0	0	0	0	C	36461541	C	C	36461541	3	2	154	1	0	0	0	0	1	0	0	0	694	1291	45	2	2289	2	ANLN	7	36461541	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3552572	36461541	122677122	321	28168											
SFRP4	6424	broad.mit.edu	37	chr7	37955825	37955825	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaggggctcgcagtcgtcGcgcgcgcgttggcacaccga	6	6	16	13	8	0	1	0	1	0	0	3	2	0	1	1	3	0	4	1	3	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:37955825G>T	uc003tfo.3	-	1	701	c.315C>A	c.(313-315)CGC>CGA	p.R105R		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	105	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						CGCAGTCGTCGCGCGCGCGTT	0.622													11	42					2.80697e-09	6.14528e-09	1	0	T	37955825	T	T	37955825	2	4	154	1	0	0	0	0	0	0	0	1	14228	1074	38	3		3	SFRP4	7	37955825	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1494284	37955825	121182838	322	28169											
POM121L12	285877	broad.mit.edu	37	chr7	53103985	53103985	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcagacagcaagggtggcagGcggaacctgcagccccggcc	9	3	15	14	2	1	1	1	0	0	1	1	2	1	2	4	5	4	3	4	5	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:53103985G>T	uc003tpz.2	+	1	637	c.621G>T	c.(619-621)AGG>AGT	p.R207S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	207											0						AGGGTGGCAGGCGGAACCTGC	0.667													17	53					2.39187e-15	5.72876e-15	1	0	T	53103985	T	T	53103985	3	4	154	1	0	0	0	0	1	0	0	0	12296	1194	42	4	623	4	POM121L12	7	53103985	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	15148160	53103985	106034678	323	28170											
ZNF479	90827	broad.mit.edu	37	chr7	57194383	57194383	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atccaggcattgccattcctCcagagagaattctatagcta	12	11	7	11	0	1	2	0	0	1	2	4	3	4	2	4	1	2	2	4	1	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:57194383C>G	uc010kzo.2	-	3	353	c.82G>C	c.(82-84)GAG>CAG	p.E28Q		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TGCCATTCCTCCAGAGAGAAT	0.438													17	64					0	0	0	0	G	57194383	G	G	57194383	3	3	154	1	0	0	0	0	1	0	0	0	18000	864	30	2	1504	2	ZNF479	7	57194383	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4090398	57194383	101944280	324	28171											
CLDN3	1365	broad.mit.edu	37	chr7	73184251	73184251	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaggccctcccagatgttCtgcgacgtgatgatgttgct	7	11	11	12	2	1	3	0	2	1	1	2	4	2	3	2	1	2	3	2	1	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:73184251C>T	uc003tzg.3	-	1	350	c.129G>A	c.(127-129)CAG>CAA	p.Q43Q	RFC2_uc011kfa.1_Intron	NM_001306	NP_001297	O15551	CLD3_HUMAN	claudin 3	43	Extracellular (Potential).				response to hypoxia	integral to plasma membrane|tight junction	structural molecule activity|transmembrane receptor activity				0		Lung NSC(55;0.159)				CCCAGATGTTCTGCGACGTGA	0.647													5	49					0	0	0	0	T	73184251	T	T	73184251	2	4	154	1	0	0	0	0	0	0	0	1	3501	912	32	2		2	CLDN3	7	73184251	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	15989868	73184251	85954412	325	28172											
HIP1	3092	broad.mit.edu	37	chr7	75189091	75189091	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtcctcccgctgcctcctGagctcgtccagttctgcccg	2	11	10	18	3	1	1	0	1	1	0	6	1	5	1	6	0	3	3	6	0	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:75189091G>A	uc003uds.1	-	14	1361	c.1320C>T	c.(1318-1320)CTC>CTT	p.L440L	HIP1_uc011kfz.1_Silent_p.L317L	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	440	Potential.|pDED.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						GCTGCCTCCTGAGCTCGTCCA	0.502			T	PDGFRB	CMML								15	72					0	0	0	0	A	75189091	A	A	75189091	2	1	154	1	0	0	0	0	0	0	0	1	7153	1277	45	2		2	HIP1	7	75189091	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2004840	75189091	83949572	326	28173											
MAGI2	9863	broad.mit.edu	37	chr7	77824251	77824251	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atatggatcaggcttccgtgGgtcaaaggcctctgttgagt	8	12	13	8	1	3	1	2	1	1	0	4	2	4	2	2	4	0	2	2	4	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:77824251G>C	uc003ugx.2	-	12	2463	c.2209C>G	c.(2209-2211)CCA>GCA	p.P737A	MAGI2_uc003ugy.2_Missense_Mutation_p.P737A|MAGI2_uc010ldx.1_Missense_Mutation_p.P346A|MAGI2_uc010ldy.1_Missense_Mutation_p.P346A	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	737						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GGCTTCCGTGGGTCAAAGGCC	0.488													11	59					0	0	0	0	C	77824251	C	C	77824251	3	2	154	1	0	0	0	0	1	0	0	0	9244	1232	43	4	2202	4	MAGI2	7	77824251	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2635160	77824251	81314412	327	28174											
SEMA3C	10512	broad.mit.edu	37	chr7	80394477	80394477	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagatgttcaaaccttaaaGacttccagctcctccagaat	14	10	6	11	0	1	3	1	0	0	3	4	4	4	3	4	0	2	2	4	0	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:80394477G>C	uc003uhj.2	-	13	1999	c.1437C>G	c.(1435-1437)GTC>GTG	p.V479V	SEMA3C_uc011kgw.1_Silent_p.V497V	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	479	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						AAACCTTAAAGACTTCCAGCT	0.378													4	70					0	0	0	0	C	80394477	C	C	80394477	2	2	154	1	0	0	0	0	0	0	0	1	14091	929	33	2		2	SEMA3C	7	80394477	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2570226	80394477	78744186	328	28175											
PCLO	27445	broad.mit.edu	37	chr7	82581261	82581261	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tacttttatagaaaaaatgtCcagcttctgctaaatttgtg	13	16	6	6	0	1	1	0	0	1	1	2	1	2	1	1	0	3	2	1	0	8	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:82581261C>T	uc003uhx.2	-	5	9297	c.9008G>A	c.(9007-9009)GGA>GAA	p.G3003E	PCLO_uc003uhv.2_Missense_Mutation_p.G3003E|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2934					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GAAAAAATGTCCAGCTTCTGC	0.408													13	253					0	0	0	0	T	82581261	T	T	82581261	3	4	154	1	0	0	0	0	1	0	0	0	11637	855	30	2	6521	2	PCLO	7	82581261	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2186784	82581261	76557402	329	28176											
ABCB1	5243	broad.mit.edu	37	chr7	87148655	87148655	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacttacaacagaacatcctCaaagctcatgagtttatgtg	14	12	6	9	0	2	2	2	1	0	1	3	2	3	2	1	0	5	2	1	0	6	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:87148655C>G	uc003uiz.1	-	24	3332	c.2914G>C	c.(2914-2916)GAG>CAG	p.E972Q	ABCB1_uc011khc.1_Missense_Mutation_p.E908Q	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	972	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AGAACATCCTCAAAGCTCATG	0.249													7	72					0	0	0	0	G	87148655	G	G	87148655	3	3	154	1	0	0	0	0	1	0	0	0	40	835	29	2	952	2	ABCB1	7	87148655	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4567394	87148655	71990008	330	28177											
ZNF804B	219578	broad.mit.edu	37	chr7	88965082	88965082	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctaacagcaaaaatcctttTagaaagagtacaagccaaga	19	8	6	8	0	1	3	0	0	1	3	2	3	2	3	2	0	4	2	2	0	8	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:88965082T>C	uc011khi.1	+	4	3324	c.2786T>C	c.(2785-2787)TTA>TCA	p.L929S		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	929						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AAAATCCTTTTAGAAAGAGTA	0.418										HNSCC(36;0.09)			39	245					0	0	0	0	C	88965082	C	C	88965082	3	2	154	1	0	0	0	0	1	0	0	0	18238	1764	61	5	2800	5	ZNF804B	7	88965082	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1816427	88965082	70173581	331	28178											
ZNF804B	219578	broad.mit.edu	37	chr7	88965672	88965672	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagaactatgcagaaacctGacaaagtcgaagacggatta	18	6	9	8	2	0	4	0	1	0	3	1	6	0	5	1	1	3	1	1	1	6	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:88965672G>C	uc011khi.1	+	4	3914	c.3376G>C	c.(3376-3378)GAC>CAC	p.D1126H		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1126						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GCAGAAACCTGACAAAGTCGA	0.338										HNSCC(36;0.09)			7	82					0	0	0	0	C	88965672	C	C	88965672	3	2	154	1	0	0	0	0	1	0	0	0	18238	1290	45	2	3390	2	ZNF804B	7	88965672	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	590	88965672	70172991	332	28179											
GTPBP10	85865	broad.mit.edu	37	chr7	89982159	89982159	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatcgataagctaagactCttcaccaggggaggatccgg	11	9	11	10	2	3	1	2	0	1	1	5	4	4	3	2	4	1	1	2	4	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:89982159C>G	uc003ukm.1	+	2	129	c.63C>G	c.(61-63)CTC>CTG	p.L21L	GTPBP10_uc003uki.1_Silent_p.L38L|GTPBP10_uc003ukj.1_Silent_p.L12L|GTPBP10_uc003ukk.1_RNA|GTPBP10_uc003ukl.1_RNA|GTPBP10_uc003ukn.1_Silent_p.L21L|GTPBP10_uc003uko.1_5'UTR	NM_033107	NP_149098	A4D1E9	GTPBA_HUMAN	GTP-binding protein 10 isoform 2	21					ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding				0						AGCTAAGACTCTTCACCAGGG	0.393											OREG0003797	type=REGULATORY REGION|Gene=BC021573|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	63					0	0	0	0	G	89982159	G	G	89982159	2	3	154	1	0	0	0	0	0	0	0	1	6918	900	32	2		2	GTPBP10	7	89982159	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1016487	89982159	69156504	333	28180											
GATAD1	57798	broad.mit.edu	37	chr7	92085756	92085756	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgcaccttctgagtatttCaagtcacggtcatcaccatt	10	13	6	12	1	5	1	4	1	1	0	5	1	5	1	2	1	1	2	2	1	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:92085756C>G	uc003ulx.1	+	5	969	c.690C>G	c.(688-690)TTC>TTG	p.F230L	GATAD1_uc011khq.1_RNA	NM_021167	NP_066990	Q8WUU5	GATD1_HUMAN	GATA zinc finger domain containing 1	230							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;1.63e-10)|all_epithelial(64;8.33e-10)|Breast(17;0.00311)|all_lung(186;0.0498)|Lung NSC(181;0.0676)		STAD - Stomach adenocarcinoma(171;4.51e-05)|GBM - Glioblastoma multiforme(5;8.83e-05)|all cancers(6;0.000136)|Lung(22;0.123)|Epithelial(20;0.179)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTGAGTATTTCAAGTCACGGT	0.453													9	150					0	0	0	0	G	92085756	G	G	92085756	3	3	154	1	0	0	0	0	1	0	0	0	6294	825	29	2	708	2	GATAD1	7	92085756	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2103597	92085756	67052907	334	28181											
COL1A2	1278	broad.mit.edu	37	chr7	94052383	94052383	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagtaggtgcagttggtcccCctggcttcgctggtgagaag	7	10	15	9	1	0	1	0	1	0	1	2	2	1	1	2	4	1	5	2	4	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:94052383C>A	uc003ung.1	+	40	2989	c.2518C>A	c.(2518-2520)CCT>ACT	p.P840T	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	840			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AGTTGGTCCCCCTGGCTTCGC	0.527										HNSCC(75;0.22)			72	105					1.03218e-28	2.57023e-28	1	0	A	94052383	A	A	94052383	3	1	154	1	0	0	0	0	1	0	0	0	3693	623	22	4	2676	4	COL1A2	7	94052383	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1966627	94052383	65086280	335	28182											
ASB4	51666	broad.mit.edu	37	chr7	95157454	95157454	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgctcatgcacatgatgctgGaagctggcgccgaagccaat	10	8	12	11	2	1	1	1	1	0	0	1	3	1	2	2	2	5	4	2	2	3	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:95157454G>C	uc011kij.1	+	3	817	c.817G>C	c.(817-819)GAA>CAA	p.E273Q	ASB4_uc003unx.2_Missense_Mutation_p.E273Q	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	273	ANK 6.				intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			CATGATGCTGGAAGCTGGCGC	0.562											OREG0018172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	60					0	0	0	0	C	95157454	C	C	95157454	3	2	154	1	0	0	0	0	1	0	0	0	1027	1175	41	2	827	2	ASB4	7	95157454	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1105071	95157454	63981209	336	28183											
SHFM1	7979	broad.mit.edu	37	chr7	96318251	96318251	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatgctatgaagtctccatCttataaccatgtttctctag	10	15	7	9	0	3	1	0	1	3	0	5	2	3	2	2	1	2	2	2	1	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:96318251C>G	uc003uoi.2	-	3	326	c.198G>C	c.(196-198)AAG>AAC	p.K66N	SHFM1_uc010lfn.1_Intron	NM_006304	NP_006295	P60896	DSS1_HUMAN	split hand/foot malformation type 1	66					proteolysis	proteasome complex	peptidase activity|protein binding				0	all_cancers(62;4.24e-09)|all_epithelial(64;5.59e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0353)|Lung NSC(181;0.0987)					AAGTCTCCATCTTATAACCAT	0.333								Direct_reversal_of_damage|Homologous_recombination					6	74					0	0	0	0	G	96318251	G	G	96318251	3	3	154	1	0	0	0	0	1	0	0	0	14343	912	32	2	18	2	SHFM1	7	96318251	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1160797	96318251	62820412	337	28184											
TECPR1	25851	broad.mit.edu	37	chr7	97851742	97851742	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atccccggtagaaggcggagCcgtcccttgccacggcccac	7	5	12	17	4	0	1	0	0	0	1	2	2	2	2	6	4	2	1	6	4	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:97851742C>G	uc003upg.2	-	22	3225	c.3020G>C	c.(3019-3021)GGC>GCC	p.G1007A		NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	1007	TECPR 7.					integral to membrane	protein binding			pancreas(1)	1						GAAGGCGGAGCCGTCCCTTGC	0.677													3	9					0	0	0	0	G	97851742	G	G	97851742	3	3	154	1	0	0	0	0	1	0	0	0	15809	739	26	4	497	4	TECPR1	7	97851742	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1533491	97851742	61286921	338	28185											
ZNF394	84124	broad.mit.edu	37	chr7	99092065	99092065	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagtccttctgcttcaggaGaattttcaagtttcaggggc	8	14	11	8	0	4	2	3	1	1	1	5	3	5	2	1	3	1	2	1	3	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:99092065G>A	uc003uqs.2	-	3	934	c.773C>T	c.(772-774)TCT>TTT	p.S258F	ZNF394_uc003uqt.2_Missense_Mutation_p.S51F	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	258					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGCTTCAGGAGAATTTTCAAG	0.483													9	146					0	0	0	0	A	99092065	A	A	99092065	3	1	154	1	0	0	0	0	1	0	0	0	17947	942	33	2	916	2	ZNF394	7	99092065	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1240323	99092065	60046598	339	28186											
STAG3	10734	broad.mit.edu	37	chr7	99779813	99779813	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aacgaccaccgaaaacaacaCcggtgagtcagccagttttc	14	6	8	13	3	1	1	1	1	0	0	2	3	1	1	4	1	4	1	4	1	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:99779813C>A	uc003utx.1	+	3	372	c.217C>A	c.(217-219)CCG>ACG	p.P73T	STAG3_uc010lgs.1_5'UTR|STAG3_uc011kjk.1_Missense_Mutation_p.P73T	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	73					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAAAACAACACCGGTGAGTCA	0.338													10	33					0.000442599	0.000850371	1	0	A	99779813	A	A	99779813	3	1	154	1	0	0	0	0	1	0	0	0	15310	507	18	4	223	4	STAG3	7	99779813	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	687748	99779813	59358850	340	28187											
LRCH4	4034	broad.mit.edu	37	chr7	100175789	100175789	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aggacgcccttacctcatttCcagaccacctcttgctgcca	8	10	6	17	1	2	1	1	0	1	1	3	2	3	2	6	1	3	1	6	1	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:100175789C>G	uc003uvj.2	-	7	994	c.941G>C	c.(940-942)GGA>GCA	p.G314A	LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjw.1_5'UTR|LRCH4_uc011kjx.1_RNA	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	314					nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TACCTCATTTCCAGACCACCT	0.592													21	35					0	0	0	0	G	100175789	G	G	100175789	3	3	154	1	0	0	0	0	1	0	0	0	8985	855	30	2	1158	2	LRCH4	7	100175789	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	395976	100175789	58962874	341	28188											
GNB2	2783	broad.mit.edu	37	chr7	100276365	100276365	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgagctgcctcggggtcaccGacgatggcatggctgtggcc	5	8	16	12	3	1	1	1	1	0	0	2	3	1	1	3	5	2	3	3	5	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:100276365G>A	uc003uwb.2	+	10	1237	c.964G>A	c.(964-966)GAC>AAC	p.D322N	GNB2_uc003uwc.2_Missense_Mutation_p.D278N|GNB2_uc010lhd.2_Missense_Mutation_p.D278N|GNB2_uc010lhe.2_Missense_Mutation_p.D278N|GNB2_uc003uwd.2_Missense_Mutation_p.D222N|GNB2_uc010lhf.2_Missense_Mutation_p.D222N|GNB2_uc003uwe.2_Missense_Mutation_p.D322N|GNB2_uc003uwf.2_Missense_Mutation_p.D222N	NM_005273	NP_005264	P62879	GBB2_HUMAN	guanine nucleotide-binding protein, beta-2	322	WD 7.				cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	perinuclear region of cytoplasm|plasma membrane	GTPase activity|GTPase binding|signal transducer activity			ovary(2)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)	Ovarian(593;0.238)				CGGGGTCACCGACGATGGCAT	0.657													9	91					0	0	0	0	A	100276365	A	A	100276365	3	1	154	1	0	0	0	0	1	0	0	0	6554	1058	37	1	998	1	GNB2	7	100276365	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	100576	100276365	58862298	342	28189											
MUC17	140453	broad.mit.edu	37	chr7	100685079	100685079	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaggaagcactccattatCaattatgcctctcagtacca	13	11	6	11	0	2	1	2	1	1	0	4	2	3	2	3	1	3	2	3	1	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:100685079C>G	uc003uxp.1	+	3	10435	c.10382C>G	c.(10381-10383)TCA>TGA	p.S3461*	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3461	Extracellular (Potential).|Ser-rich.|56.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACTCCATTATCAATTATGCCT	0.502													156	439					0	0	0	0	G	100685079	G	G	100685079	4	3	154	1	0	0	0	0	0	1	0	0	10027	838	29	2	10392	2	MUC17	7	100685079	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	408714	100685079	58453584	343	28190											
CUX1	1523	broad.mit.edu	37	chr7	101843412	101843412	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatgaagccatcaagtccatCctagagcaagccaagaggga	15	5	11	10	0	1	3	1	1	0	2	3	5	3	4	4	1	3	1	4	1	5	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:101843412C>G	uc003uyx.3	+	17	2060	c.2022C>G	c.(2020-2022)ATC>ATG	p.I674M	CUX1_uc003uys.3_Missense_Mutation_p.I685M|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	674	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						TCAAGTCCATCCTAGAGCAAG	0.483													8	90					0	0	0	0	G	101843412	G	G	101843412	3	3	154	1	0	0	0	0	1	0	0	0	4081	845	30	2	2155	2	CUX1	7	101843412	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1158333	101843412	57295251	344	28191											
RELN	5649	broad.mit.edu	37	chr7	103138678	103138678	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtttgatttcttcactgtCaaagcgttccttcaggaaag	10	14	9	8	1	4	1	3	1	1	0	5	2	5	2	1	2	1	2	1	2	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:103138678C>G	uc003vca.2	-	54	8849	c.8689G>C	c.(8689-8691)GAC>CAC	p.D2897H	RELN_uc010liz.2_Missense_Mutation_p.D2897H	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2897					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCTTCACTGTCAAAGCGTTCC	0.373													6	71					0	0	0	0	G	103138678	G	G	103138678	3	3	154	1	0	0	0	0	1	0	0	0	13285	826	29	2	1741	2	RELN	7	103138678	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1295266	103138678	55999985	345	28192											
ATXN7L1	222255	broad.mit.edu	37	chr7	105516849	105516849	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcagtgtaatttggcggcGtcgatccaggaggaccaggg	9	7	17	8	3	0	0	0	0	0	0	2	4	1	2	2	5	1	2	2	5	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:105516849G>T	uc003vde.2	-	1	183	c.156C>A	c.(154-156)GAC>GAA	p.D52E	ATXN7L1_uc003vdi.2_Missense_Mutation_p.D52E|CDHR3_uc003vdk.2_5'Flank|uc003vdj.1_5'Flank	NM_020725	NP_065776	Q9ULK2	AT7L1_HUMAN	ataxin 7-like 1 isoform 1	52											0						ATTTGGCGGCGTCGATCCAGG	0.527													8	12					5.18039e-06	1.05407e-05	1	0	T	105516849	T	T	105516849	3	4	154	1	0	0	0	0	1	0	0	0	1218	1136	40	3	2570	3	ATXN7L1	7	105516849	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2378171	105516849	53621814	346	28193											
PIK3CG	5294	broad.mit.edu	37	chr7	106509407	106509407	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctattatgtgaacctgctGctgatagaccaccgtttcct	8	14	7	12	1	1	3	0	2	1	1	2	3	2	3	4	0	3	3	4	0	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:106509407G>T	uc003vdv.3	+	2	1486	c.1401G>T	c.(1399-1401)CTG>CTT	p.L467L	PIK3CG_uc003vdu.2_Silent_p.L467L|PIK3CG_uc003vdw.2_Silent_p.L467L	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	467					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TGAACCTGCTGCTGATAGACC	0.532													32	62					5.6714e-07	1.18412e-06	1	0	T	106509407	T	T	106509407	2	4	154	1	0	0	0	0	0	0	0	1	11971	1306	46	4		4	PIK3CG	7	106509407	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	992558	106509407	52629256	347	28194											
SLC26A4	5172	broad.mit.edu	37	chr7	107340590	107340590	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctattttctatggcaatgtCgatggttttaaaaaatgtat	12	17	7	5	1	1	0	0	0	1	0	2	1	1	0	1	2	0	3	1	2	7	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:107340590C>T	uc003vep.2	+	15	1901	c.1677C>T	c.(1675-1677)GTC>GTT	p.V559V	SLC26A4_uc011kmb.1_Silent_p.V146V|SLC26A4_uc011kmc.1_Silent_p.V120V|SLC26A4_uc011kmd.1_Silent_p.V128V	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	559	STAS.|Cytoplasmic (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						ATGGCAATGTCGATGGTTTTA	0.284									Pendred_syndrome				14	27					0	0	0	0	T	107340590	T	T	107340590	2	4	154	1	0	0	0	0	0	0	0	1	14583	871	31	1		1	SLC26A4	7	107340590	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	831183	107340590	51798073	348	28195											
CHRM2	1129	broad.mit.edu	37	chr7	136699801	136699801	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcaacaattactttttattCagcttggcctgtgctgacct	8	16	7	10	0	2	1	2	1	0	0	2	1	2	1	2	1	4	2	2	1	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:136699801C>G	uc003vtf.1	+	4	812	c.189C>G	c.(187-189)TTC>TTG	p.F63L	CHRM2_uc003vtg.1_Missense_Mutation_p.F63L|CHRM2_uc003vtj.1_Missense_Mutation_p.F63L|CHRM2_uc003vtk.1_Missense_Mutation_p.F63L|CHRM2_uc003vtl.1_Missense_Mutation_p.F63L|CHRM2_uc003vtm.1_Missense_Mutation_p.F63L|CHRM2_uc003vti.1_Missense_Mutation_p.F63L|CHRM2_uc003vto.1_Missense_Mutation_p.F63L|CHRM2_uc003vtn.1_Missense_Mutation_p.F63L|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	63	Helical; Name=2; (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ACTTTTTATTCAGCTTGGCCT	0.468													12	122					0	0	0	0	G	136699801	G	G	136699801	3	3	154	1	0	0	0	0	1	0	0	0	3392	825	29	2	191	2	CHRM2	7	136699801	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	29359211	136699801	22438862	349	28196											
BRAF	673	broad.mit.edu	37	chr7	140449137	140449137	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taactgtccagtcatcaattCatacagaacaattccaaatg	16	11	4	10	0	3	1	3	0	0	1	5	1	5	1	2	0	3	0	2	0	6	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:140449137C>G	uc003vwc.3	-	16	2003	c.1942G>C	c.(1942-1944)GAA>CAA	p.E648Q		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	648	Protein kinase.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	GTCATCAATTCATACAGAACA	0.363		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				8	38					0	0	0	0	G	140449137	G	G	140449137	3	3	154	1	0	0	0	0	1	0	0	0	1501	835	29	2	370	2	BRAF	7	140449137	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3749336	140449137	18689526	350	28197											
AGK	55750	broad.mit.edu	37	chr7	141315363	141315363	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccgaaagtggaaacaaagtCcagtaggttgtcaatgtggg	13	8	14	6	1	1	0	1	0	0	0	2	2	2	1	2	3	1	2	2	3	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:141315363C>A	uc003vwi.2	+	8	687	c.516C>A	c.(514-516)GTC>GTA	p.V172V	AGK_uc011krg.1_RNA	NM_018238	NP_060708	Q53H12	AGK_HUMAN	acylglycerol kinase precursor	172	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			ovary(1)|breast(1)	2	Melanoma(164;0.0171)					GAAACAAAGTCCAGTAGGTTG	0.438													18	153					5.01169e-05	9.9218e-05	1	0	A	141315363	A	A	141315363	2	1	154	1	0	0	0	0	0	0	0	1	383	842	30	2		2	AGK	7	141315363	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	866226	141315363	17823300	351	28198											
TAS2R38	5726	broad.mit.edu	37	chr7	141673226	141673226	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggcttggtagctgtggttCagtggttcactcaacttctg	6	15	12	8	0	4	0	3	0	1	0	4	0	4	0	0	4	2	5	0	4	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:141673226C>T	uc003vwx.1	-	1	348	c.264G>A	c.(262-264)CTG>CTA	p.L88L		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	88	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					AGCTGTGGTTCAGTGGTTCAC	0.527													12	140					0	0	0	0	T	141673226	T	T	141673226	2	4	154	1	0	0	0	0	0	0	0	1	15641	813	29	2		2	TAS2R38	7	141673226	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	357863	141673226	17465437	352	28199											
MGAM	8972	broad.mit.edu	37	chr7	141736654	141736654	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcctcctttggagctgactCcctgctgttgaattcctcca	5	14	8	14	0	0	2	0	2	0	0	4	3	4	3	5	1	3	3	5	1	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:141736654C>T	uc003vwy.2	+	18	2162	c.2108C>T	c.(2107-2109)TCC>TTC	p.S703F		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	703	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGAGCTGACTCCCTGCTGTTG	0.532													15	217					0	0	0	0	T	141736654	T	T	141736654	3	4	154	1	0	0	0	0	1	0	0	0	9594	855	30	2	2174	2	MGAM	7	141736654	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	63428	141736654	17402009	353	28200											
OR6B1	135946	broad.mit.edu	37	chr7	143701434	143701434	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcacagaatgtgtgcttctGgccgccatggcctatgaccg	7	10	12	12	2	1	2	0	1	1	1	1	2	1	2	4	2	2	2	4	2	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:143701434G>C	uc003wdt.1	+	1	345	c.345G>C	c.(343-345)CTG>CTC	p.L115L		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					GTGTGCTTCTGGCCGCCATGG	0.498													29	58					0	0	0	0	C	143701434	C	C	143701434	2	2	154	1	0	0	0	0	0	0	0	1	11241	1335	47	4		4	OR6B1	7	143701434	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1964780	143701434	15437229	354	28201											
ARHGEF5	7984	broad.mit.edu	37	chr7	144060360	144060360	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaccagaatgaaggctctGaaagtgggactatcaggcag	14	6	12	9	0	2	3	1	2	1	1	2	4	2	4	2	3	1	2	2	3	5	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr7:144060360G>T	uc003wel.2	+	2	716	c.598G>T	c.(598-600)GAA>TAA	p.E200*	ARHGEF5_uc003wek.2_Nonsense_Mutation_p.E200*	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	200					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					TGAAGGCTCTGAAAGTGGGAC	0.522													16	518					1.3612e-06	2.8186e-06	1	0	T	144060360	T	T	144060360	4	4	154	1	0	0	0	0	0	1	0	0	909	1291	45	2	600	2	ARHGEF5	7	144060360	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	358926	144060360	15078303	355	28202											
LPL	4023	broad.mit.edu	37	chr8	19811807	19811807	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccgaatggaggtacttttCagccaggatgtaacattgga	12	10	11	8	1	1	0	1	0	0	0	1	4	1	3	2	4	3	2	2	4	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:19811807C>T	uc003wzk.3	+	5	1088	c.718C>T	c.(718-720)CAG>TAG	p.Q240*		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	240					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity	p.Q240*(1)		ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	AGGTACTTTTCAGCCAGGATG	0.443													12	56					0	0	0	0	T	19811807	T	T	19811807	4	4	154	1	0	0	0	0	0	1	0	0	8971	827	29	2	736	2	LPL	8	19811807	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08		19811807	126552215	356	28203											
TEX15	56154	broad.mit.edu	37	chr8	30702709	30702709	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatcatttaaaaagtgcttCacatttgaatctaagactga	16	13	6	6	0	3	4	2	2	1	2	3	4	3	4	0	0	1	1	0	0	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:30702709C>G	uc003xil.2	-	1	3825	c.3825G>C	c.(3823-3825)GTG>GTC	p.V1275V		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1275										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AAAAGTGCTTCACATTTGAAT	0.358													13	34					0	0	0	0	G	30702709	G	G	30702709	2	3	154	1	0	0	0	0	0	0	0	1	15845	813	29	2		2	TEX15	8	30702709	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	10890902	30702709	115661313	357	28204											
PRKDC	5591	broad.mit.edu	37	chr8	48697804	48697804	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcatgttggtaatgtcgttGaagtcactgagcttcattct	9	15	10	7	1	3	2	2	2	1	0	4	2	3	2	0	1	2	5	0	1	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:48697804G>A	uc003xqi.2	-	78	11034	c.10977C>T	c.(10975-10977)TTC>TTT	p.F3659F	PRKDC_uc003xqj.2_Silent_p.F3659F|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3659					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TAATGTCGTTGAAGTCACTGA	0.363								NHEJ					6	32					0	0	0	0	A	48697804	A	A	48697804	2	1	154	1	0	0	0	0	0	0	0	1	12583	1281	45	2		2	PRKDC	8	48697804	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	17995095	48697804	97666218	358	28205											
MOS	4342	broad.mit.edu	37	chr8	57026507	57026507	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgatggggaaaactcgctcCggaggtaggggcgtagggcc	8	5	18	10	4	0	0	0	0	0	0	2	3	1	2	3	7	1	3	3	7	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:57026507C>A	uc011leb.1	-	1	35	c.35G>T	c.(34-36)CGG>CTG	p.R12L		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	12							ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			AAACTCGCTCCGGAGGTAGGG	0.677													7	32					0.00307968	0.00575353	1	0	A	57026507	A	A	57026507	3	1	154	1	0	0	0	0	1	0	0	0	9765	652	23	3	1008	3	MOS	8	57026507	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	8328703	57026507	89337515	359	28206											
TOX	9760	broad.mit.edu	37	chr8	59872534	59872534	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacatagtcctggctcggctCtgtcatgctcatatacatgt	8	13	8	12	1	3	0	2	0	1	0	5	0	4	0	1	2	2	3	1	2	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:59872534C>G	uc003xtw.1	-	2	357	c.136G>C	c.(136-138)GAG>CAG	p.E46Q		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	46						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				TGGCTCGGCTCTGTCATGCTC	0.368													3	55					0	0	0	0	G	59872534	G	G	59872534	3	3	154	1	0	0	0	0	1	0	0	0	16444	922	32	2	1476	2	TOX	8	59872534	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2846027	59872534	86491488	360	28207											
EYA1	2138	broad.mit.edu	37	chr8	72127676	72127676	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaatacaattcctaacccatAcagcaggactttcgccaatg	15	9	5	12	1	0	0	0	0	0	0	2	1	1	1	3	1	4	1	3	1	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:72127676A>G	uc003xys.3	-	15	1830	c.1543T>C	c.(1543-1545)TAT>CAT	p.Y515H	EYA1_uc003xyr.3_Missense_Mutation_p.Y480H|EYA1_uc003xyt.3_Missense_Mutation_p.Y482H|EYA1_uc010lzf.2_Missense_Mutation_p.Y442H|EYA1_uc003xyu.2_Missense_Mutation_p.Y515H|EYA1_uc011lfe.1_Missense_Mutation_p.Y509H|EYA1_uc003xyv.2_Missense_Mutation_p.Y393H	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	515					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CCTAACCCATACAGCAGGACT	0.348													42	68					0	0	0	0	G	72127676	G	G	72127676	3	3	154	1	0	0	0	0	1	0	0	0	5353	391	14	5	247	5	EYA1	8	72127676	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	12255142	72127676	74236346	361	28208											
KCNB2	9312	broad.mit.edu	37	chr8	73849296	73849296	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagcctgagaggccatctgCatatgaagaagagattgaaa	17	7	11	6	0	1	5	0	3	1	3	1	7	1	5	2	1	2	1	2	1	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:73849296C>G	uc003xzb.2	+	3	2294	c.1706C>G	c.(1705-1707)GCA>GGA	p.A569G		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	569	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGGCCATCTGCATATGAAGAA	0.507													7	78					0	0	0	0	G	73849296	G	G	73849296	3	3	154	1	0	0	0	0	1	0	0	0	8052	710	25	4	1712	4	KCNB2	8	73849296	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1721620	73849296	72514726	362	28209											
ZFHX4	79776	broad.mit.edu	37	chr8	77617387	77617387	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttctactacaaacctcatagGacccgatccaaccttccgcg	11	9	5	16	3	2	0	1	0	1	0	4	2	4	1	5	1	4	0	5	1	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:77617387G>C	uc003yav.2	+	2	1451	c.1064G>C	c.(1063-1065)GGA>GCA	p.G355A	ZFHX4_uc003yat.1_Missense_Mutation_p.G355A|ZFHX4_uc003yau.1_Missense_Mutation_p.G355A|ZFHX4_uc003yaw.1_Missense_Mutation_p.G355A	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	355						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AACCTCATAGGACCCGATCCA	0.448										HNSCC(33;0.089)			13	98					0	0	0	0	C	77617387	C	C	77617387	3	2	154	1	0	0	0	0	1	0	0	0	17702	1174	41	2	1066	2	ZFHX4	8	77617387	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3768091	77617387	68746635	363	28210											
ZFHX4	79776	broad.mit.edu	37	chr8	77765696	77765696	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaacactggtttagaaataCgctttttaaggaacgacaga	16	10	8	7	2	0	2	0	0	0	2	0	4	0	3	0	2	3	2	0	2	6	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:77765696C>G	uc003yav.2	+	10	6791	c.6404C>G	c.(6403-6405)ACG>AGG	p.T2135R	ZFHX4_uc003yau.1_Missense_Mutation_p.T2180R|ZFHX4_uc003yaw.1_Missense_Mutation_p.T2135R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2135	Homeobox 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTTAGAAATACGCTTTTTAAG	0.373										HNSCC(33;0.089)			55	90					0	0	0	0	G	77765696	G	G	77765696	3	3	154	1	0	0	0	0	1	0	0	0	17702	536	19	3	6573	3	ZFHX4	8	77765696	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	148309	77765696	68598326	364	28211											
RUNX1T1	862	broad.mit.edu	37	chr8	92983035	92983035	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcagacacggccttctgcaGctccgtcatcgcctggcgct	5	9	10	17	4	3	1	2	0	1	1	5	1	4	1	3	2	2	3	3	2	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:92983035G>C	uc003yfd.2	-	10	1474	c.1390C>G	c.(1390-1392)CTG>GTG	p.L464V	RUNX1T1_uc003yfc.1_Missense_Mutation_p.L437V|RUNX1T1_uc003yfe.1_Missense_Mutation_p.L427V|RUNX1T1_uc010mao.2_Missense_Mutation_p.L437V|RUNX1T1_uc011lgi.1_Missense_Mutation_p.L475V|RUNX1T1_uc010man.1_Missense_Mutation_p.L89V|RUNX1T1_uc003yfb.1_Missense_Mutation_p.L427V	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	464					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A464S(1)		lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GCCTTCTGCAGCTCCGTCATC	0.597													3	49					0	0	0	0	C	92983035	C	C	92983035	3	2	154	1	0	0	0	0	1	0	0	0	13812	962	34	4	432	4	RUNX1T1	8	92983035	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	15217339	92983035	53380987	365	28212											
ESRP1	54845	broad.mit.edu	37	chr8	95680467	95680467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttcaggagcacagcagctGaagttcagcaggttggtttt	9	12	12	8	0	3	1	2	1	1	0	3	2	3	2	0	3	4	7	0	3	1	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:95680467G>A	uc003ygq.3	+	10	1405	c.1222G>A	c.(1222-1224)GAA>AAA	p.E408K	ESRP1_uc003ygr.3_Missense_Mutation_p.E408K|ESRP1_uc003ygs.3_Missense_Mutation_p.E408K|ESRP1_uc003ygt.3_Missense_Mutation_p.E408K|ESRP1_uc003ygu.3_Missense_Mutation_p.E408K|ESRP1_uc003ygv.2_Missense_Mutation_p.E248K|ESRP1_uc003ygw.2_Missense_Mutation_p.E248K	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	408					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						CACAGCAGCTGAAGTTCAGCA	0.373													8	55					0	0	0	0	A	95680467	A	A	95680467	3	1	154	1	0	0	0	0	1	0	0	0	5282	1291	45	2	1260	2	ESRP1	8	95680467	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2697432	95680467	50683555	366	28213											
MTERFD1	51001	broad.mit.edu	37	chr8	97270606	97270606	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctagaaacagctcagaatCaaagctggatatattttgtg	14	13	8	6	0	3	2	2	0	1	2	3	3	3	3	0	1	3	2	0	1	6	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:97270606C>G	uc003yhs.1	-	2	391	c.313G>C	c.(313-315)GAT>CAT	p.D105H	MTERFD1_uc003yhr.1_5'Flank|MTERFD1_uc010mbd.1_Missense_Mutation_p.D105H	NM_015942	NP_057026	Q96E29	MTER1_HUMAN	MTERF domain containing 1 precursor	105					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			ovary(1)	1	Breast(36;5.16e-05)					AGCTCAGAATCAAAGCTGGAT	0.413													6	36					0	0	0	0	G	97270606	G	G	97270606	3	3	154	1	0	0	0	0	1	0	0	0	9972	826	29	2	968	2	MTERFD1	8	97270606	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1590139	97270606	49093416	367	28214											
OXR1	55074	broad.mit.edu	37	chr8	107715290	107715290	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caatgtacaaagaaattttgGatagcaaaataaaggaatct	20	10	7	4	0	1	1	0	0	1	1	1	3	1	3	0	2	2	2	0	2	10	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:107715290G>A	uc011lht.1	+	7	934	c.835G>A	c.(835-837)GAT>AAT	p.D279N	OXR1_uc003ymf.2_Missense_Mutation_p.D278N|OXR1_uc011lhu.1_Missense_Mutation_p.D271N|OXR1_uc010mcg.2_Intron|OXR1_uc003ymg.1_Missense_Mutation_p.D211N|OXR1_uc003ymi.1_Missense_Mutation_p.D190N	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	279					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			AGAAATTTTGGATAGCAAAAT	0.353													17	27					0	0	0	0	A	107715290	A	A	107715290	3	1	154	1	0	0	0	0	1	0	0	0	11388	1174	41	2	1061	2	OXR1	8	107715290	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	10444684	107715290	38648732	368	28215											
OXR1	55074	broad.mit.edu	37	chr8	107763141	107763141	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggaagatttctttatccAagatattgaaatctgggctt	13	14	9	5	0	2	3	0	1	2	2	3	5	3	4	1	2	0	1	1	2	6	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:107763141A>G	uc011lht.1	+	16	2696	c.2597A>G	c.(2596-2598)CAA>CGA	p.Q866R	OXR1_uc003ymf.2_Missense_Mutation_p.Q838R|OXR1_uc011lhu.1_Missense_Mutation_p.Q831R|OXR1_uc010mcg.2_RNA|OXR1_uc010mch.2_Missense_Mutation_p.Q494R|OXR1_uc003ymk.2_Missense_Mutation_p.Q235R|OXR1_uc003yml.2_Missense_Mutation_p.Q208R	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	866					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			TTCTTTATCCAAGATATTGAA	0.388													18	58					0	0	0	0	G	107763141	G	G	107763141	3	3	154	1	0	0	0	0	1	0	0	0	11388	130	5	5	2774	5	OXR1	8	107763141	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	47851	107763141	38600881	369	28216											
TRHR	7201	broad.mit.edu	37	chr8	110100017	110100017	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatctacggttcctgggtCtatggctatgttggatgcct	6	15	12	8	1	2	0	0	0	2	0	3	1	3	1	2	4	2	4	2	4	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:110100017C>A	uc003ymz.3	+	1	292	c.276C>A	c.(274-276)GTC>GTA	p.V92V		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	92	Extracellular (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GTTCCTGGGTCTATGGCTATG	0.483													43	83					3.05275e-18	7.40238e-18	1	0	A	110100017	A	A	110100017	2	1	154	1	0	0	0	0	0	0	0	1	16547	900	32	2		2	TRHR	8	110100017	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2336876	110100017	36264005	370	28217											
NUDCD1	84955	broad.mit.edu	37	chr8	110293364	110293364	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaagccgtatggttactgtCaaatcatcttcagtctgttg	9	14	10	8	1	5	0	3	0	2	0	5	1	5	1	1	2	2	3	1	2	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:110293364C>G	uc003ynb.3	-	6	972	c.861G>C	c.(859-861)TTG>TTC	p.L287F	NUDCD1_uc003yna.2_Missense_Mutation_p.L258F|NUDCD1_uc010mcl.2_Missense_Mutation_p.L200F|NUDCD1_uc010mcm.1_Missense_Mutation_p.L200F	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	287	CS.									ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			TGGTTACTGTCAAATCATCTT	0.363													4	51					0	0	0	0	G	110293364	G	G	110293364	3	3	154	1	0	0	0	0	1	0	0	0	10776	825	29	2	910	2	NUDCD1	8	110293364	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	193347	110293364	36070658	371	28218											
PKHD1L1	93035	broad.mit.edu	37	chr8	110420425	110420425	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccactcactctatggtcatCagaagctgaagtacggtgta	11	10	10	10	1	4	2	3	1	1	1	4	2	4	2	1	2	2	3	1	2	5	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:110420425C>G	uc003yne.2	+	18	2065	c.1961C>G	c.(1960-1962)TCA>TGA	p.S654*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	654	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTATGGTCATCAGAAGCTGAA	0.448										HNSCC(38;0.096)			10	37					0	0	0	0	G	110420425	G	G	110420425	4	3	154	1	0	0	0	0	0	1	0	0	12027	838	29	2	2031	2	PKHD1L1	8	110420425	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	127061	110420425	35943597	372	28219											
KCNV1	27012	broad.mit.edu	37	chr8	110984839	110984839	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgaagataatggagatgacGccaaagatacgggcagctgt	15	6	13	7	3	0	4	0	1	0	3	0	6	0	4	1	2	2	2	1	2	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:110984839G>T	uc003ynr.3	-	2	981	c.639C>A	c.(637-639)GGC>GGA	p.G213G	KCNV1_uc010mcw.2_Silent_p.G213G	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	213	Helical; Name=Segment S1; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TGGAGATGACGCCAAAGATAC	0.522													25	32					2.39556e-15	5.7298e-15	1	0	T	110984839	T	T	110984839	2	4	154	1	0	0	0	0	0	0	0	1	8133	1074	38	3		3	KCNV1	8	110984839	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	564414	110984839	35379183	373	28220											
CSMD3	114788	broad.mit.edu	37	chr8	113243846	113243846	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatacataagtagctccatCaggctcagcagaaacctaaa	18	7	6	10	0	2	1	2	0	0	1	3	1	3	1	2	1	4	4	2	1	7	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:113243846C>T	uc003ynu.2	-	69	10915	c.10756G>A	c.(10756-10758)GAT>AAT	p.D3586N	CSMD3_uc003yns.2_Missense_Mutation_p.D2788N|CSMD3_uc003ynt.2_Missense_Mutation_p.D3546N|CSMD3_uc011lhx.1_Missense_Mutation_p.D3417N	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3586	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTAGCTCCATCAGGCTCAGCA	0.323										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	122					0	0	0	0	T	113243846	T	T	113243846	3	4	154	1	0	0	0	0	1	0	0	0	3963	826	29	2	379	2	CSMD3	8	113243846	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2259007	113243846	33120176	374	28221											
CSMD3	114788	broad.mit.edu	37	chr8	113562955	113562955	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	taaaaatccgtgtcaaactgGatggttactatattgagggt	13	13	10	5	1	1	1	1	1	0	0	2	2	2	2	1	3	2	1	1	3	7	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:113562955G>T	uc003ynu.2	-	27	4668	c.4509C>A	c.(4507-4509)ATC>ATA	p.I1503I	CSMD3_uc003yns.2_Silent_p.I775I|CSMD3_uc003ynt.2_Silent_p.I1463I|CSMD3_uc011lhx.1_Silent_p.I1399I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1503	Extracellular (Potential).|CUB 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGTCAAACTGGATGGTTACTA	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	75					5.4927e-09	1.18918e-08	1	0	T	113562955	T	T	113562955	2	4	154	1	0	0	0	0	0	0	0	1	3963	1164	41	2		2	CSMD3	8	113562955	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	319109	113562955	32801067	375	28222											
EXT1	2131	broad.mit.edu	37	chr8	118849376	118849376	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaggaatctgaaggaccCaagcctgcgaccacgaggaa	13	4	11	13	2	1	1	0	1	1	0	2	6	2	4	4	3	2	0	4	3	4	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:118849376C>A	uc003yok.1	-	2	1800	c.1027G>T	c.(1027-1029)GGG>TGG	p.G343W		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	343	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			CTGAAGGACCCAAGCCTGCGA	0.493			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				16	153					1.01871e-10	2.28722e-10	1	0	A	118849376	A	A	118849376	3	1	154	1	0	0	0	0	1	0	0	0	5348	594	21	4	1253	4	EXT1	8	118849376	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	5286421	118849376	27514646	376	28223											
COL14A1	7373	broad.mit.edu	37	chr8	121295907	121295907	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaaggattgccctccgactAcacaatcagttttctattcc	11	12	6	12	1	2	1	1	0	1	1	4	3	4	2	3	1	2	1	3	1	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:121295907A>G	uc003yox.2	+	32	4122	c.3857A>G	c.(3856-3858)TAC>TGC	p.Y1286C	COL14A1_uc003yoz.2_Missense_Mutation_p.Y251C	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1286	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CCCTCCGACTACACAATCAGT	0.388													41	93					0	0	0	0	G	121295907	G	G	121295907	3	3	154	1	0	0	0	0	1	0	0	0	3686	391	14	5	3979	5	COL14A1	8	121295907	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	2446531	121295907	25068115	377	28224											
FAM135B	51059	broad.mit.edu	37	chr8	139263149	139263149	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	accgagatcacagacaggtgGaaatagtcgaacatgaccgg	15	5	12	9	3	1	3	1	1	0	2	2	6	1	4	2	3	1	0	2	3	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:139263149G>T	uc003yuy.2	-	6	648	c.477C>A	c.(475-477)TTC>TTA	p.F159L	FAM135B_uc003yux.2_Missense_Mutation_p.F60L|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	159										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAGACAGGTGGAAATAGTCGA	0.592										HNSCC(54;0.14)			24	138					2.52088e-20	6.15514e-20	1	0	T	139263149	T	T	139263149	3	4	154	1	0	0	0	0	1	0	0	0	5477	1165	41	2	3803	2	FAM135B	8	139263149	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	17967242	139263149	7100873	378	28225											
COL22A1	169044	broad.mit.edu	37	chr8	139729092	139729092	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctccaggtcggcctgccagGccctgctccccaatttctcc	4	10	8	19	1	2	0	0	0	2	0	6	0	3	0	7	3	2	1	7	3	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:139729092G>A	uc003yvd.2	-	28	2823	c.2376C>T	c.(2374-2376)GGC>GGT	p.G792G	COL22A1_uc011ljo.1_Silent_p.G92G	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	792	Pro-rich.|Gly-rich.|Collagen-like 6.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGCCTGCCAGGCCCTGCTCCC	0.368										HNSCC(7;0.00092)			13	47					0	0	0	0	A	139729092	A	A	139729092	2	1	154	1	0	0	0	0	0	0	0	1	3696	1190	42	4		4	COL22A1	8	139729092	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	465943	139729092	6634930	379	28226											
COL22A1	169044	broad.mit.edu	37	chr8	139790645	139790645	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggagtccaggtggtccttggGgcccctgcagaagagcattt	7	9	15	10	0	0	2	0	0	0	2	2	3	2	3	4	5	2	2	4	5	1	2	rs149741596	by1000genomes	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:139790645G>T	uc003yvd.2	-	15	2156	c.1709C>A	c.(1708-1710)CCC>CAC	p.P570H		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	570	Pro-rich.|Gly-rich.|Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TGGTCCTTGGGGCCCCTGCAG	0.562										HNSCC(7;0.00092)			7	30					0.00448238	0.00834748	1	0	T	139790645	T	T	139790645	3	4	154	1	0	0	0	0	1	0	0	0	3696	1232	43	4	3375	4	COL22A1	8	139790645	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	61553	139790645	6573377	380	28227											
LY6K	54742	broad.mit.edu	37	chr8	143783130	143783130	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactgcgttatagcggccgtGagtgagtatcttcgctcttg	6	14	12	9	4	2	2	0	2	2	0	3	2	2	2	1	1	3	3	1	1	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:143783130G>C	uc011ljv.1	+	2	633	c.216G>C	c.(214-216)GTG>GTC	p.V72V	LY6K_uc011ljw.1_Silent_p.V72V|LY6K_uc011ljx.1_Silent_p.V72V	NM_017527	NP_059997	Q17RY6	LY6K_HUMAN	lymphocyte antigen 6 complex, locus K isoform 1	72	UPAR/Ly6.					anchored to membrane|cytoplasm|extracellular region|nucleolus|plasma membrane				central_nervous_system(1)	1	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TAGCGGCCGTGAGTGAGTATC	0.483													3	16					0	0	0	0	C	143783130	C	C	143783130	2	2	154	1	0	0	0	0	0	0	0	1	9149	1304	45	2		2	LY6K	8	143783130	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3992485	143783130	2580892	381	28228											
ARHGAP39	80728	broad.mit.edu	37	chr8	145773627	145773627	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcggggagctgctccctggGagctcggccctcttcaggaa	6	7	15	13	2	2	0	1	0	1	0	4	3	3	3	2	5	4	3	2	5	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr8:145773627G>A	uc003zdt.1	-	6	1398	c.843C>T	c.(841-843)CTC>CTT	p.L281L	ARHGAP39_uc011llk.1_Silent_p.L281L|ARHGAP39_uc003zds.1_Silent_p.L281L	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	281	Pro-rich.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						TGCTCCCTGGGAGCTCGGCCC	0.692													5	18					0	0	0	0	A	145773627	A	A	145773627	2	1	154	1	0	0	0	0	0	0	0	1	884	1161	41	2		2	ARHGAP39	8	145773627	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1990497	145773627	590395	382	28229											
KIAA1432	57589	broad.mit.edu	37	chr9	5754839	5754839	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttaaaaaatttttattttaAggagcaaaatatgatcgtga	17	16	6	2	1	0	2	0	2	0	0	1	3	0	3	0	1	1	1	0	1	8	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:5754839A>T	uc003zji.2	+	14	1459	c.1366_splice	c.e14-2	p.E456_splice	KIAA1432_uc003zjh.2_Splice_Site_p.E456_splice|KIAA1432_uc003zjl.3_Splice_Site_p.E419_splice|KIAA1432_uc003zjj.1_Splice_Site	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a							integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		ttttattttaaGGAGCAAAAT	0.294													6	16					0	0	0	0	T	5754839	T	T	5754839	5	4	154	1	0	0	0	0	0	0	1	0	8272	86	3	5	1418	5	KIAA1432	9	5754839	Splice_Site	SNP	A	TCGA-CR-7388-01A-11D-2012-08		5754839	135458592	383	28230											
PTPRD	5789	broad.mit.edu	37	chr9	8517884	8517884	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacttgtatgtcacttgaaaGgggaccatctccaattgagg	11	11	11	8	0	2	2	1	2	1	0	3	4	2	3	2	3	0	1	2	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:8517884G>T	uc003zkk.2	-	20	2218	c.1507C>A	c.(1507-1509)CTT>ATT	p.L503I	PTPRD_uc003zkp.2_Missense_Mutation_p.L503I|PTPRD_uc003zkq.2_Missense_Mutation_p.L503I|PTPRD_uc003zkr.2_Missense_Mutation_p.L497I|PTPRD_uc003zks.2_Missense_Mutation_p.L493I|PTPRD_uc003zkl.2_Missense_Mutation_p.L503I|PTPRD_uc003zkm.2_Missense_Mutation_p.L490I|PTPRD_uc003zkn.2_Missense_Mutation_p.L503I|PTPRD_uc003zko.2_Missense_Mutation_p.L500I	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	503	Fibronectin type-III 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCACTTGAAAGGGGACCATCT	0.468										TSP Lung(15;0.13)			15	44					5.35267e-07	1.1189e-06	1	0	T	8517884	T	T	8517884	3	4	154	1	0	0	0	0	1	0	0	0	12864	1000	35	4	4403	4	PTPRD	9	8517884	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2763045	8517884	132695547	384	28231											
FAM154A	158297	broad.mit.edu	37	chr9	18928826	18928826	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcatgcacaaagcgcttctCcacggggtgggccacatagc	9	8	11	13	2	2	0	1	0	1	0	3	0	2	0	2	3	3	2	2	3	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:18928826C>T	uc003zni.1	-	4	927	c.649G>A	c.(649-651)GAG>AAG	p.E217K	FAM154A_uc010mip.1_Missense_Mutation_p.E25K	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	217										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		AAGCGCTTCTCCACGGGGTGG	0.512													9	51					0	0	0	0	T	18928826	T	T	18928826	3	4	154	1	0	0	0	0	1	0	0	0	5491	864	30	2	779	2	FAM154A	9	18928826	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	10410942	18928826	122284605	385	28232											
ACO1	48	broad.mit.edu	37	chr9	32418476	32418476	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgggcacagactcgcacactAccatgattgatggcttgggc	9	9	12	11	1	0	3	0	2	0	1	1	3	0	3	1	3	1	3	1	3	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:32418476A>G	uc003zqw.3	+	6	780	c.625A>G	c.(625-627)ACC>GCC	p.T209A	ACO1_uc010mjh.1_Missense_Mutation_p.T43A|ACO1_uc003zqx.3_Missense_Mutation_p.T209A|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	209					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		CTCGCACACTACCATGATTGA	0.433													42	140					0	0	0	0	G	32418476	G	G	32418476	3	3	154	1	0	0	0	0	1	0	0	0	146	391	14	5	643	5	ACO1	9	32418476	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	13489650	32418476	108794955	386	28233											
ACO1	48	broad.mit.edu	37	chr9	32420929	32420929	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagcccagttgtccattgctGaccgagctacgattgctaac	9	11	9	12	2	0	1	0	1	0	0	1	3	1	1	3	0	6	4	3	0	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:32420929G>A	uc003zqw.3	+	8	1029	c.874G>A	c.(874-876)GAC>AAC	p.D292N	ACO1_uc010mjh.1_Missense_Mutation_p.D126N|ACO1_uc003zqx.3_Missense_Mutation_p.D292N|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	292					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		GTCCATTGCTGACCGAGCTAC	0.502													9	163					0	0	0	0	A	32420929	A	A	32420929	3	1	154	1	0	0	0	0	1	0	0	0	146	1290	45	2	900	2	ACO1	9	32420929	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2453	32420929	108792502	387	28234											
TLN1	7094	broad.mit.edu	37	chr9	35707190	35707190	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgggctgtctggatgagtcCcccggcactctctaacattg	6	10	11	14	2	2	1	0	1	2	0	4	2	3	2	3	3	1	2	3	3	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:35707190C>G	uc003zxt.2	-	37	5188	c.4834G>C	c.(4834-4836)GGA>CGA	p.G1612R		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1612	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGGATGAGTCCCCCGGCACTC	0.637													11	48					0	0	0	0	G	35707190	G	G	35707190	3	3	154	1	0	0	0	0	1	0	0	0	16013	632	22	4	2875	4	TLN1	9	35707190	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3286261	35707190	105506241	388	28235											
TLN1	7094	broad.mit.edu	37	chr9	35716451	35716451	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggcagcacttaagagcttgCgggagttctccagatcactt	9	11	11	10	1	2	2	1	0	1	2	3	3	2	3	1	2	3	4	1	2	1	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:35716451C>A	uc003zxt.2	-	20	2915	c.2561G>T	c.(2560-2562)CGC>CTC	p.R854L		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	854					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TAAGAGCTTGCGGGAGTTCTC	0.567													22	86					1.96292e-10	4.39595e-10	1	0	A	35716451	A	A	35716451	3	1	154	1	0	0	0	0	1	0	0	0	16013	768	27	3	5216	3	TLN1	9	35716451	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	9261	35716451	105496980	389	28236											
NPR2	4882	broad.mit.edu	37	chr9	35801681	35801681	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggctagcatgttgtggcGtattcgctgggaagaactgc	7	11	15	8	2	0	1	0	0	0	1	1	2	0	2	0	3	3	6	0	3	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:35801681G>T	uc003zyd.2	+	8	1478	c.1478G>T	c.(1477-1479)CGT>CTT	p.R493L	NPR2_uc010mlb.2_Missense_Mutation_p.R493L	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	493	Cytoplasmic (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	ATGTTGTGGCGTATTCGCTGG	0.552													23	45					1.64293e-13	3.86133e-13	1	0	T	35801681	T	T	35801681	3	4	154	1	0	0	0	0	1	0	0	0	10649	1145	40	3	1508	3	NPR2	9	35801681	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	85230	35801681	105411750	390	28237											
FRMPD1	22844	broad.mit.edu	37	chr9	37740292	37740292	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagtgccgagtccgaggcGtccgactcagccaacactga	10	5	12	14	4	1	1	1	1	0	0	3	5	3	1	4	1	3	0	4	1	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:37740292G>T	uc004aag.1	+	15	1811	c.1767G>T	c.(1765-1767)GCG>GCT	p.A589A	FRMPD1_uc004aah.1_Silent_p.A589A|FRMPD1_uc011lqm.1_Silent_p.A411A|FRMPD1_uc011lqn.1_Silent_p.A458A	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	589						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		AGTCCGAGGCGTCCGACTCAG	0.647													8	37					0.000157383	0.000305386	1	0	T	37740292	T	T	37740292	2	4	154	1	0	0	0	0	0	0	0	1	6091	1132	40	3		3	FRMPD1	9	37740292	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1938611	37740292	103473139	391	28238											
FAM75A3	727830	broad.mit.edu	37	chr9	40702830	40702830	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcctcaagccaagcatcctCaggatctggcctccacccca	10	7	6	18	0	3	0	2	0	1	0	6	1	6	1	7	2	2	1	7	2	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:40702830C>G	uc010mmj.2	+	4	516	c.487C>G	c.(487-489)CAG>GAG	p.Q163E		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	163	Pro-rich.					integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CAAGCATCCTCAGGATCTGGC	0.587													9	385					0	0	0	0	G	40702830	G	G	40702830	3	3	154	1	0	0	0	0	1	0	0	0	5653	827	29	2	501	2	FAM75A3	9	40702830	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2962538	40702830	100510601	392	28239											
FAM75A6	389730	broad.mit.edu	37	chr9	43626924	43626924	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtctccggagttcaggaCtgactggaaagttctcaggc	8	11	13	9	1	3	1	2	1	2	0	5	4	3	4	1	4	0	3	1	4	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:43626924C>A	uc011lrb.1	-	4	1792	c.1763G>T	c.(1762-1764)AGT>ATT	p.S588I		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	588						integral to membrane					0						GAGTTCAGGACTGACTGGAAA	0.493													13	128					2.37509e-13	5.5598e-13	1	0	A	43626924	A	A	43626924	3	1	154	1	0	0	0	0	1	0	0	0	5654	565	20	4	2272	4	FAM75A6	9	43626924	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2924094	43626924	97586507	393	28240											
TMEM2	23670	broad.mit.edu	37	chr9	74360399	74360399	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tatagcggcatttttctgctCcaatatgaagcgccccacca	10	11	7	13	2	1	1	0	1	1	0	2	1	2	1	4	1	3	2	4	1	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:74360399C>A	uc011lsa.1	-	4	1109	c.569G>T	c.(568-570)GGA>GTA	p.G190V	TMEM2_uc010mos.2_Missense_Mutation_p.G190V|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	190	G8.					integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TTTTTCTGCTCCAATATGAAG	0.413													34	62					1.26612e-14	3.00382e-14	1	0	A	74360399	A	A	74360399	3	1	154	1	0	0	0	0	1	0	0	0	16187	855	30	2	3666	2	TMEM2	9	74360399	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	30733475	74360399	66853032	394	28241											
TLE4	7091	broad.mit.edu	37	chr9	82227616	82227616	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctatctgtgcacaagtcattCctttcctgtcccaagaggta	9	13	7	12	0	2	1	1	0	1	1	5	1	5	1	3	1	1	2	3	1	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:82227616C>G	uc004ald.2	+	5	1126	c.277C>G	c.(277-279)CCT>GCT	p.P93A	TLE4_uc004alc.2_Missense_Mutation_p.P100A|TLE4_uc010mpr.2_5'UTR|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Missense_Mutation_p.P93A|TLE4_uc010mps.2_Missense_Mutation_p.P93A|TLE4_uc004alf.2_Missense_Mutation_p.P38A	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						ACAAGTCATTCCTTTCCTGTC	0.418													6	88					0	0	0	0	G	82227616	G	G	82227616	3	3	154	1	0	0	0	0	1	0	0	0	16007	855	30	2	316	2	TLE4	9	82227616	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	7867217	82227616	58985815	395	28242											
FLJ46321	389763	broad.mit.edu	37	chr9	84603894	84603894	+	Frame_Shift_Del	DEL	C	-	-																															gaccctgtattcgtcacccaCcgaaaaaaataatgacatcc																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:84603894delC	uc004amn.2	+	1	208	c.161delC	c.(160-162)ACCfs	p.T54fs		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	54						integral to membrane					0						TCGTCACCCACCGAAAAAAAT	0.428													---	---	---								-	84603894	-	-	84603894	7	5	154	1	0	1	0	1	0	0	0	0	5964	507	18	0	163	0	FLJ46321	9	84603894	Frame_Shift_Del	DEL	C	TCGA-CR-7388-01A-11D-2012-08	2376278	84603894	56609537	396	28243											
FLJ46321	389763	broad.mit.edu	37	chr9	84606461	84606461	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcttcagaattcacctggtGgcagcctcatgccaaggact	10	10	9	12	0	4	1	3	0	1	1	4	2	4	2	3	3	2	1	3	3	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:84606461G>T	uc004amn.2	+	4	1123	c.1076G>T	c.(1075-1077)TGG>TTG	p.W359L		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	359						integral to membrane					0						TTCACCTGGTGGCAGCCTCAT	0.478													15	85					1.02788e-11	2.34678e-11	1	0	T	84606461	T	T	84606461	3	4	154	1	0	0	0	0	1	0	0	0	5964	1357	47	4	1090	4	FLJ46321	9	84606461	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2567	84606461	56606970	397	28244											
GKAP1	80318	broad.mit.edu	37	chr9	86414160	86414160	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgtgaatccttctgtactggGtttgacaatggaagatcatg	10	13	11	7	1	2	3	1	2	1	1	3	4	3	4	1	2	1	2	1	2	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:86414160G>C	uc004amy.2	-	4	796	c.300C>G	c.(298-300)AAC>AAG	p.N100K	GKAP1_uc004amz.2_Missense_Mutation_p.N100K|GKAP1_uc011lsu.1_RNA	NM_025211	NP_079487	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1 isoform a	100					signal transduction	Golgi apparatus					0						TCTGTACTGGGTTTGACAATG	0.363													35	134					0	0	0	0	C	86414160	C	C	86414160	3	2	154	1	0	0	0	0	1	0	0	0	6460	1252	44	4	840	4	GKAP1	9	86414160	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1807699	86414160	54799271	398	28245											
KIF27	55582	broad.mit.edu	37	chr9	86452160	86452160	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatcatctgtttctgttttaTtctcattacctaacatatgc	9	20	3	9	0	4	0	2	0	3	0	5	0	4	0	1	0	3	2	1	0	5	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:86452160T>C	uc004ana.2	-	18	4106	c.3962A>G	c.(3961-3963)AAT>AGT	p.N1321S	KIF27_uc010mpw.2_Missense_Mutation_p.N1255S|KIF27_uc010mpx.2_Missense_Mutation_p.N1224S	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	1321					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TTCTGTTTTATTCTCATTACC	0.418													24	24					0	0	0	0	C	86452160	C	C	86452160	3	2	154	1	0	0	0	0	1	0	0	0	8335	1493	52	5	247	5	KIF27	9	86452160	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	38000	86452160	54761271	399	28246											
FAM75C1	441452	broad.mit.edu	37	chr9	90536023	90536023	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctctccttacctgaaactCagcaccctgaaaggcctttg	9	11	6	15	0	2	2	1	2	1	0	4	2	3	2	4	1	3	1	4	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:90536023C>T	uc010mqi.2	+	4	1230	c.1201C>T	c.(1201-1203)CAG>TAG	p.Q401*	FAM75C1_uc004apq.3_Nonsense_Mutation_p.Q384*	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						ACCTGAAACTCAGCACCCTGA	0.498													9	331					0	0	0	0	T	90536023	T	T	90536023	4	4	154	1	0	0	0	0	0	1	0	0	5655	827	29	2	1215	2	FAM75C1	9	90536023	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4083863	90536023	50677408	400	28247											
PTCH1	5727	broad.mit.edu	37	chr9	98270530	98270530	+	Frame_Shift_Del	DEL	C	-	-																															ggcgcggcagcacggcgcagCccccccgtccgtctgcgcct																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:98270530delC	uc004avk.3	-	1	302	c.114delG	c.(112-114)GGGfs	p.G38fs	PTCH1_uc010mro.2_5'Flank|PTCH1_uc010mrp.2_5'Flank|PTCH1_uc010mrq.2_5'Flank|PTCH1_uc004avl.3_5'Flank|PTCH1_uc010mrr.2_Intron|PTCH1_uc004avm.3_Intron|PTCH1_uc010mrt.1_5'Flank|PTCH1_uc010mru.1_5'Flank|PTCH1_uc004avo.2_Intron|PTCH1_uc010mrv.1_Intron|PTCH1_uc010mrw.1_Intron	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	38	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CACGGCGCAGCCCCCCCGTCC	0.736									Basal_Cell_Nevus_syndrome				---	---	---								-	98270530	-	-	98270530	7	5	154	1	0	1	0	1	0	0	0	0	12792	726	26	0	4321	0	PTCH1	9	98270530	Frame_Shift_Del	DEL	C	TCGA-CR-7388-01A-11D-2012-08	7734507	98270530	42942901	401	28248											
ALDOB	229	broad.mit.edu	37	chr9	104187801	104187801	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catagctacttgttctggagTatacttcttggtgcaggcat	8	15	10	8	0	2	0	0	0	2	0	2	1	2	1	0	3	4	5	0	3	4	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:104187801T>A	uc004bbk.2	-	7	815	c.733A>T	c.(733-735)ACT>TCT	p.T245S		NM_000035	NP_000026	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	245					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				TGTTCTGGAGTATACTTCTTG	0.507													22	78					0	0	0	0	A	104187801	A	A	104187801	3	1	154	1	0	0	0	0	1	0	0	0	508	1638	57	5	373	5	ALDOB	9	104187801	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	5917271	104187801	37025630	402	28249											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112899231	112899231	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaagaatcctggcattgcAgcaaaatggtggaatccccc	14	7	10	10	0	0	2	0	0	0	2	2	3	2	3	3	3	2	3	3	3	6	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:112899231A>G	uc004bei.2	+	9	2295	c.2103A>G	c.(2101-2103)GCA>GCG	p.A701A	PALM2-AKAP2_uc004bek.3_Silent_p.A469A|PALM2-AKAP2_uc004bej.3_Silent_p.A469A|PALM2-AKAP2_uc004bel.1_Silent_p.A279A|AKAP2_uc011lwi.1_Silent_p.A327A|AKAP2_uc004bem.2_Silent_p.A327A|PALM2-AKAP2_uc010mtw.1_Silent_p.A287A|AKAP2_uc011lwj.1_Silent_p.A238A|PALM2-AKAP2_uc004ben.2_Silent_p.A238A	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	238	Potential.						enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						CTGGCATTGCAGCAAAATGGT	0.522													12	39					0	0	0	0	G	112899231	G	G	112899231	2	3	154	1	0	0	0	0	0	0	0	1	11464	175	7	5		5	PALM2-AKAP2	9	112899231	Silent	SNP	A	TCGA-CR-7388-01A-11D-2012-08	8711430	112899231	28314200	403	28250											
SVEP1	79987	broad.mit.edu	37	chr9	113208279	113208279	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcatgacatatccatagatgCcagaaacttcaaaatccagg	16	8	7	10	0	1	3	1	1	0	2	3	3	3	3	3	1	2	1	3	1	5	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:113208279C>G	uc010mtz.2	-	26	4638	c.4301G>C	c.(4300-4302)GGC>GCC	p.G1434A	SVEP1_uc010mua.1_Missense_Mutation_p.G1434A	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1434	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TCCATAGATGCCAGAAACTTC	0.423													4	28					0	0	0	0	G	113208279	G	G	113208279	3	3	154	1	0	0	0	0	1	0	0	0	15486	739	26	4	6506	4	SVEP1	9	113208279	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	309048	113208279	28005152	404	28251											
DBC1	1620	broad.mit.edu	37	chr9	121976297	121976297	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgatggggcagttgcactgCggaaactcctcggcacattg	8	9	14	10	2	0	1	0	1	0	0	2	2	1	2	1	4	3	4	1	4	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:121976297C>G	uc004bkc.2	-	6	1278	c.822G>C	c.(820-822)CCG>CCC	p.P274P	DBC1_uc004bkd.2_Silent_p.P274P	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	274					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						AGTTGCACTGCGGAAACTCCT	0.552													18	88					0	0	0	0	G	121976297	G	G	121976297	2	3	154	1	0	0	0	0	0	0	0	1	4264	755	27	3		3	DBC1	9	121976297	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	8768018	121976297	19237134	405	28252											
DBC1	1620	broad.mit.edu	37	chr9	122075438	122075438	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtatattttatatctggttgTaaatccttgacggtgtcttt	8	20	8	5	1	2	1	0	1	2	0	3	1	3	1	1	2	0	3	1	2	6	9			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:122075438T>C	uc004bkc.2	-	2	652	c.196A>G	c.(196-198)ACA>GCA	p.T66A	DBC1_uc004bkd.2_Missense_Mutation_p.T66A	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	66					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TATCTGGTTGTAAATCCTTGA	0.443													5	31					0	0	0	0	C	122075438	C	C	122075438	3	2	154	1	0	0	0	0	1	0	0	0	4264	1638	57	5	2117	5	DBC1	9	122075438	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	99141	122075438	19137993	406	28253											
CEP110	11064	broad.mit.edu	37	chr9	123930380	123930380	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattctttattaagatgtttCagagactccagaaagagaga	15	13	8	5	0	2	5	1	0	1	5	3	7	3	5	1	0	0	1	1	0	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:123930380C>T	uc004bkx.1	+	36	5882	c.5851C>T	c.(5851-5853)CAG>TAG	p.Q1951*	CEP110_uc004blb.1_Nonsense_Mutation_p.Q620*|CEP110_uc010mvp.1_5'UTR	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1951	Required for centrosome localization.|Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						TAAGATGTTTCAGAGACTCCA	0.378													4	16					0	0	0	0	T	123930380	T	T	123930380	4	4	154	1	0	0	0	0	0	1	0	0	3260	827	29	2	5993	2	CEP110	9	123930380	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1854942	123930380	17283051	407	28254											
RC3H2	54542	broad.mit.edu	37	chr9	125643074	125643074	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcatctcttttggtaacCtaaaaaatagaaaagagaaa	18	12	5	6	0	3	2	1	0	2	2	4	3	3	2	1	1	1	1	1	1	8	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:125643074C>A	uc010mwc.1	-	6	1001	c.760_splice	c.e6-1	p.V254_splice	RC3H2_uc004bnc.2_Splice_Site|RC3H2_uc004bnd.1_Splice_Site_p.V254_splice|RC3H2_uc004bne.3_Splice_Site_p.V254_splice|RC3H2_uc011lzf.1_Translation_Start_Site|RC3H2_uc011lzg.1_Splice_Site_p.V254_splice|SNORD90_uc004bnf.1_5'Flank	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2							cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						TTTTGGTAACCTAAAAAATAG	0.388													4	23					0.00024832	0.000480778	1	0	A	125643074	A	A	125643074	5	1	154	1	0	0	0	0	0	0	1	0	13232	695	24	4	2958	4	RC3H2	9	125643074	Splice_Site	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1712694	125643074	15570357	408	28255											
HSPA5	3309	broad.mit.edu	37	chr9	127998972	127998972	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgaacaatttcttccagttCcttcttcttagctttgaagt	8	19	5	9	0	3	2	0	2	3	0	5	2	5	2	2	0	2	2	2	0	4	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:127998972C>T	uc004bpn.2	-	8	2120	c.1864G>A	c.(1864-1866)GAA>AAA	p.E622K		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	622					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	TCTTCCAGTTCCTTCTTCTTA	0.418										Prostate(1;0.17)			32	47					0	0	0	0	T	127998972	T	T	127998972	3	4	154	1	0	0	0	0	1	0	0	0	7453	864	30	2	104	2	HSPA5	9	127998972	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2355898	127998972	13214459	409	28256											
CDK9	1025	broad.mit.edu	37	chr9	130551532	130551532	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccagaagcggaaggtgaagGacaggctgaaggcctatgtg	12	5	17	7	1	0	3	0	2	0	1	0	5	0	5	2	5	1	1	2	5	5	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:130551532G>A	uc004bse.2	+	7	952	c.829G>A	c.(829-831)GAC>AAC	p.D277N		NM_001261	NP_001252	P50750	CDK9_HUMAN	cyclin-dependent kinase 9	277	Protein kinase.				cell proliferation|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription elongation factor complex	ATP binding|cyclin-dependent protein kinase activity|DNA binding|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(1)	1						GAAGGTGAAGGACAGGCTGAA	0.602													12	31					0	0	0	0	A	130551532	A	A	130551532	3	1	154	1	0	0	0	0	1	0	0	0	3166	1174	41	2	855	2	CDK9	9	130551532	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2552560	130551532	10661899	410	28257											
PRRX2	51450	broad.mit.edu	37	chr9	132482945	132482945	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctggccagccgctctgcctCgctgctcaagtcctacagcc	5	8	10	18	2	2	0	1	0	1	0	4	0	3	0	5	1	5	4	5	1	2	1	rs144448846		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:132482945C>T	uc004byh.2	+	3	745	c.518C>T	c.(517-519)TCG>TTG	p.S173L		NM_016307	NP_057391	Q99811	PRRX2_HUMAN	paired related homeobox 2	173						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		Ovarian(14;0.00556)				CGCTCTGCCTCGCTGCTCAAG	0.592													17	96					0	0	0	0	T	132482945	T	T	132482945	3	4	154	1	0	0	0	0	1	0	0	0	12675	893	31	1	528	1	PRRX2	9	132482945	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1931413	132482945	8730486	411	28258											
LAMC3	10319	broad.mit.edu	37	chr9	133945219	133945219	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagcaatgtccgtcctgctaCgccctggtgaaggaggaggt	8	8	14	11	2	0	1	0	1	0	0	2	3	2	3	3	4	3	2	3	4	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:133945219C>T	uc004caa.1	+	17	3149	c.3051C>T	c.(3049-3051)TAC>TAT	p.Y1017Y		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1017	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CGTCCTGCTACGCCCTGGTGA	0.587													3	5					0	0	0	0	T	133945219	T	T	133945219	2	4	154	1	0	0	0	0	0	0	0	1	8656	547	19	1		1	LAMC3	9	133945219	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1462274	133945219	7268212	412	28259											
NUP214	8021	broad.mit.edu	37	chr9	134073156	134073156	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaggatcctctggggtcatCagttttggtgggacatctct	6	13	13	9	0	4	0	2	0	2	0	6	2	5	2	1	5	0	2	1	5	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:134073156C>G	uc004cag.2	+	29	4386	c.4275C>G	c.(4273-4275)ATC>ATG	p.I1425M	NUP214_uc004cah.2_Missense_Mutation_p.I1415M|NUP214_uc004cai.2_Missense_Mutation_p.I855M|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.I251M|NUP214_uc011mcf.1_Missense_Mutation_p.I202M|NUP214_uc010mzh.1_Translation_Start_Site|NUP214_uc010mzi.1_Translation_Start_Site	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1425	Pro/Ser/Thr-rich.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		CTGGGGTCATCAGTTTTGGTG	0.537			T	DEK|SET|ABL1	AML|T-ALL								17	102					0	0	0	0	G	134073156	G	G	134073156	3	3	154	1	0	0	0	0	1	0	0	0	10816	816	29	2	4389	2	NUP214	9	134073156	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	127937	134073156	7140275	413	28260			2	44		3	3	404	C		5.878992e-05
NUP214	8021	broad.mit.edu	37	chr9	134073548	134073548	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caactctggcactgcagcatCtagtactagtcttgtagcac	10	11	8	12	0	3	0	0	0	3	0	3	0	3	0	0	1	5	6	0	1	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:134073548C>G	uc004cag.2	+	29	4778	c.4667C>G	c.(4666-4668)TCT>TGT	p.S1556C	NUP214_uc004cah.2_Missense_Mutation_p.S1546C|NUP214_uc004cai.2_Missense_Mutation_p.S986C|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.S382C|NUP214_uc011mcf.1_Missense_Mutation_p.S333C|NUP214_uc010mzh.1_Missense_Mutation_p.S70C|NUP214_uc010mzi.1_Missense_Mutation_p.S70C	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1556	Pro/Ser/Thr-rich.|11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		ACTGCAGCATCTAGTACTAGT	0.557			T	DEK|SET|ABL1	AML|T-ALL								10	65					0	0	0	0	G	134073548	G	G	134073548	3	3	154	1	0	0	0	0	1	0	0	0	10816	913	32	2	4781	2	NUP214	9	134073548	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	392	134073548	7139883	414	28261			2	44		3	3	404	C		5.878992e-05
NUP214	8021	broad.mit.edu	37	chr9	134073559	134073559	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagcatctagtactagtCttgtagcactttctgcagag	9	13	9	10	0	3	1	0	0	3	1	3	1	3	1	0	0	5	6	0	0	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:134073559C>A	uc004cag.2	+	29	4789	c.4678C>A	c.(4678-4680)CTT>ATT	p.L1560I	NUP214_uc004cah.2_Missense_Mutation_p.L1550I|NUP214_uc004cai.2_Missense_Mutation_p.L990I|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.L386I|NUP214_uc011mcf.1_Missense_Mutation_p.L337I|NUP214_uc010mzh.1_Missense_Mutation_p.L74I|NUP214_uc010mzi.1_Missense_Mutation_p.L74I	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1560	Pro/Ser/Thr-rich.|11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TAGTACTAGTCTTGTAGCACT	0.562			T	DEK|SET|ABL1	AML|T-ALL								9	63					5.4927e-09	1.18918e-08	1	0	A	134073559	A	A	134073559	3	1	154	1	0	0	0	0	1	0	0	0	10816	913	32	2	4792	2	NUP214	9	134073559	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	11	134073559	7139872	415	28262			2	44		3	3	404	C		5.878992e-05
SEC16A	9919	broad.mit.edu	37	chr9	139371758	139371758	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggggctcacagggtccctGagagctatctctggcatgtg	7	9	14	11	0	2	1	1	1	1	1	4	2	3	1	1	4	1	3	1	4	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr9:139371758G>A	uc004chx.2	-	3	619	c.310C>T	c.(310-312)CAG>TAG	p.Q104*	SEC16A_uc004chv.3_5'Flank|SEC16A_uc004chw.2_Nonsense_Mutation_p.Q104*|SEC16A_uc010nbn.2_Nonsense_Mutation_p.Q104*|SEC16A_uc010nbo.1_Nonsense_Mutation_p.Q104*	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CAGGGTCCCTGAGAGCTATCT	0.592													11	93					0	0	0	0	A	139371758	A	A	139371758	4	1	154	1	0	0	0	0	0	1	0	0	14051	1299	45	2	6883	2	SEC16A	9	139371758	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5298199	139371758	1841673	416	28263											
ITGA8	8516	broad.mit.edu	37	chr10	15686196	15686196	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcctctttgatccttgcctGcaaaaggcactccgatggca	8	11	9	13	1	1	1	0	1	1	0	3	2	3	1	4	2	3	3	4	2	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:15686196G>A	uc001ioc.1	-	13	1232	c.1232C>T	c.(1231-1233)GCA>GTA	p.A411V	ITGA8_uc010qcb.1_Missense_Mutation_p.A396V	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	411	Extracellular (Potential).|FG-GAP 6.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						ATCCTTGCCTGCAAAAGGCAC	0.358													13	22					0	0	0	0	A	15686196	A	A	15686196	3	1	154	1	0	0	0	0	1	0	0	0	7921	1319	46	4	2031	4	ITGA8	10	15686196	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08		15686196	119848551	417	28264											
NSUN6	221078	broad.mit.edu	37	chr10	18885189	18885189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttccctccaggtgctgcaCacaagtctagaatcttctct	8	14	6	13	0	3	1	0	0	3	1	6	1	5	1	2	1	2	2	2	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:18885189C>T	uc010qcp.1	-	7	1143	c.725G>A	c.(724-726)TGT>TAT	p.C242Y		NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	242	S-adenosyl-L-methionine binding (By similarity).						methyltransferase activity|RNA binding			ovary(2)	2						AGGTGCTGCACACAAGTCTAG	0.388													11	52					0	0	0	0	T	18885189	T	T	18885189	3	4	154	1	0	0	0	0	1	0	0	0	10736	478	17	4	704	4	NSUN6	10	18885189	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3198993	18885189	116649558	418	28265											
ARHGAP12	94134	broad.mit.edu	37	chr10	32101646	32101646	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctaccaacctttaatataaCctttttcacgaacagcttgc	12	13	3	13	1	1	0	1	0	0	0	1	1	1	0	4	0	6	1	4	0	6	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:32101646C>G	uc001ivz.1	-	15	2210	c.1940G>C	c.(1939-1941)GGT>GCT	p.G647A	ARHGAP12_uc001ivy.1_Missense_Mutation_p.G593A|ARHGAP12_uc009xls.2_Missense_Mutation_p.G598A|ARHGAP12_uc001iwb.1_Missense_Mutation_p.G640A|ARHGAP12_uc001iwc.1_Missense_Mutation_p.G615A|ARHGAP12_uc009xlq.1_Missense_Mutation_p.G568A|ARHGAP12_uc001iwd.1_Missense_Mutation_p.G615A	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	647					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				TTTAATATAACCTTTTTCACG	0.308													6	47					0	0	0	0	G	32101646	G	G	32101646	3	3	154	1	0	0	0	0	1	0	0	0	865	507	18	4	624	4	ARHGAP12	10	32101646	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	13216457	32101646	103433101	419	28266											
MAPK8	5599	broad.mit.edu	37	chr10	49633957	49633957	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcagtggaataaagttattGaacagcttggaacaccatgt	15	11	9	6	0	1	1	1	1	0	0	1	3	1	3	1	2	3	2	1	2	6	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:49633957G>C	uc009xnz.2	+	8	939	c.715G>C	c.(715-717)GAA>CAA	p.E239Q	MAPK8_uc001jgl.2_Missense_Mutation_p.E239Q|MAPK8_uc001jgm.2_Missense_Mutation_p.E239Q|MAPK8_uc001jgo.2_Missense_Mutation_p.E239Q|MAPK8_uc009xoa.2_Intron|MAPK8_uc001jgn.2_Missense_Mutation_p.E239Q|MAPK8_uc010qgk.1_Missense_Mutation_p.E239Q|MAPK8_uc001jgp.2_Missense_Mutation_p.E239Q|MAPK8_uc001jgq.2_Missense_Mutation_p.E239Q	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	239	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		TAAAGTTATTGAACAGCTTGG	0.318													3	39					0	0	0	0	C	49633957	C	C	49633957	3	2	154	1	0	0	0	0	1	0	0	0	9336	1291	45	2	817	2	MAPK8	10	49633957	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	17532311	49633957	85900790	420	28267											
CSTF2T	23283	broad.mit.edu	37	chr10	53458085	53458085	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatctctaccacctctacCatccataggtagaccccttt	11	11	4	15	0	2	2	0	0	2	2	4	2	3	2	6	1	2	1	6	1	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:53458085C>A	uc001jjp.2	-	1	1271	c.1225G>T	c.(1225-1227)GGT>TGT	p.G409C	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	409	Gly-rich.				mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		CCACCTCTACCATCCATAGGT	0.522													25	115					2.12542e-12	4.93591e-12	1	0	A	53458085	A	A	53458085	3	1	154	1	0	0	0	0	1	0	0	0	4002	594	21	4	629	4	CSTF2T	10	53458085	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3824128	53458085	82076662	421	28268											
CCDC6	8030	broad.mit.edu	37	chr10	61592413	61592413	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggctttctcatgctgcaacTggaaaatgaaaaacaccgag	14	8	9	10	2	1	1	1	1	1	0	2	3	1	2	1	2	4	3	1	2	5	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:61592413T>A	uc001jks.3	-	3	1090	c.454_splice	c.e3-1	p.L152_splice		NM_005436	NP_005427	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6							cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton			ovary(3)|breast(1)	4				Kidney(211;0.0597)		ATGCTGCAACTGGAAAATGAA	0.398													6	28					0	0	0	0	A	61592413	A	A	61592413	5	1	154	1	0	0	0	0	0	0	1	0	2843	1594	55	5	1000	5	CCDC6	10	61592413	Splice_Site	SNP	T	TCGA-CR-7388-01A-11D-2012-08	8134328	61592413	73942334	422	28269											
CCDC6	8030	broad.mit.edu	37	chr10	61666097	61666097	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caccgccgccgcccgaggtcGacgagcaggacgactgcatg	8	3	14	16	7	0	0	0	0	0	0	1	5	0	1	4	2	2	2	4	2	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:61666097G>C	uc001jks.3	-	1	722	c.86C>G	c.(85-87)TCG>TGG	p.S29W		NM_005436	NP_005427	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	29						cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton			ovary(3)|breast(1)	4				Kidney(211;0.0597)		gccCGAGGTCGACGAGCAGGA	0.582													5	41					0	0	0	0	C	61666097	C	C	61666097	3	2	154	1	0	0	0	0	1	0	0	0	2843	1059	37	3	1374	3	CCDC6	10	61666097	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	73684	61666097	73868650	423	28270											
LRRTM3	347731	broad.mit.edu	37	chr10	68687295	68687295	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgctggcatgatcagactCaaagaacttcacctggagca	12	10	9	10	0	3	3	3	1	0	2	3	4	3	4	1	2	3	3	1	2	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:68687295C>G	uc001jmz.1	+	2	1171	c.621C>G	c.(619-621)CTC>CTG	p.L207L	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Silent_p.L207L	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	207	Extracellular (Potential).|LRR 7.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TGATCAGACTCAAAGAACTTC	0.458													10	120					0	0	0	0	G	68687295	G	G	68687295	2	3	154	1	0	0	0	0	0	0	0	1	9091	813	29	2		2	LRRTM3	10	68687295	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	7021198	68687295	66847452	424	28271											
HERC4	26091	broad.mit.edu	37	chr10	69785429	69785429	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccaaaagtaaacactccaCcttcctaaaaaaagacaaaa	21	6	2	12	0	0	1	0	0	0	1	3	1	3	1	4	0	1	1	4	0	10	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:69785429C>A	uc001jng.3	-	8	1093	c.782G>T	c.(781-783)GGT>GTT	p.G261V	HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.G261V|HERC4_uc009xpr.2_Missense_Mutation_p.G261V|HERC4_uc001jni.3_Missense_Mutation_p.G5V|HERC4_uc001jnj.2_Missense_Mutation_p.G261V	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	261	RCC1 6.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						AAACACTCCACCTTCCTAAAA	0.358													12	65					1.08611e-07	2.29492e-07	1	0	A	69785429	A	A	69785429	3	1	154	1	0	0	0	0	1	0	0	0	7099	507	18	4	2467	4	HERC4	10	69785429	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1098134	69785429	65749318	425	28272											
RUFY2	55680	broad.mit.edu	37	chr10	70164518	70164518	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagtgcggccaaagctcaGagcagattcaatgagtcctt	13	8	10	10	1	2	3	2	1	0	2	3	3	3	3	2	1	3	2	2	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:70164518G>C	uc001job.2	-	2	520	c.193C>G	c.(193-195)CTG>GTG	p.L65V	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Missense_Mutation_p.L30V|RUFY2_uc010qiw.1_Intron|RUFY2_uc001jod.1_Missense_Mutation_p.L30V|RUFY2_uc009xpv.1_5'UTR|RUFY2_uc001joe.1_Missense_Mutation_p.L30V	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	79						nucleus	metal ion binding			ovary(1)	1						CCAAAGCTCAGAGCAGATTCA	0.428													8	38					0	0	0	0	C	70164518	C	C	70164518	3	2	154	1	0	0	0	0	1	0	0	0	13804	933	33	2	1913	2	RUFY2	10	70164518	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	379089	70164518	65370229	426	28273											
ANXA7	310	broad.mit.edu	37	chr10	75156946	75156946	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtggaacctgtgctggacCacctccataagactgtgaag	11	9	11	10	0	0	2	0	1	0	1	1	4	1	4	4	2	2	1	4	2	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:75156946C>A	uc001jtz.2	-	4	419	c.346G>T	c.(346-348)GGT>TGT	p.G116C	ANXA7_uc001jua.2_Missense_Mutation_p.G116C|ANXA7_uc001jub.2_Missense_Mutation_p.G76C|ANXA7_uc010qki.1_Intron|ANXA7_uc009xre.2_Missense_Mutation_p.G45C|ANXA7_uc009xrf.1_Intron	NM_004034	NP_004025	P20073	ANXA7_HUMAN	annexin VII isoform 2	116	Repeat-rich region.						calcium ion binding|calcium-dependent phospholipid binding|calcium-dependent protein binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					TGTGCTGGACCACCTCCATAA	0.463													6	25					0.00307968	0.00575353	1	0	A	75156946	A	A	75156946	3	1	154	1	0	0	0	0	1	0	0	0	723	594	21	4	1164	4	ANXA7	10	75156946	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4992428	75156946	60377801	427	28274											
POLR3A	11128	broad.mit.edu	37	chr10	79784811	79784811	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttcagtcctcgcttctgaagGtaggtcaggccgggcctctt	5	12	12	12	2	4	1	2	1	2	0	6	1	5	1	3	4	0	2	3	4	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:79784811G>A	uc001jzn.2	-	4	502	c.408C>T	c.(406-408)TAC>TAT	p.Y136Y		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	136					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GCTTCTGAAGGTAGGTCAGGC	0.463													18	83					0	0	0	0	A	79784811	A	A	79784811	2	1	154	1	0	0	0	0	0	0	0	1	12283	1256	44	4		4	POLR3A	10	79784811	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4627865	79784811	55749936	428	28275											
LRIT1	26103	broad.mit.edu	37	chr10	85991723	85991723	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttctcctgccccctttgactCcaaaggcctgaaagtccaca	9	10	6	16	0	1	2	0	2	1	0	4	2	3	2	6	1	1	0	6	1	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:85991723C>G	uc001kcz.1	-	4	1854	c.1832G>C	c.(1831-1833)GGA>GCA	p.G611A		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	611	Cytoplasmic (Potential).					integral to endoplasmic reticulum membrane					0						CCCTTTGACTCCAAAGGCCTG	0.577													5	23					0	0	0	0	G	85991723	G	G	85991723	3	3	154	1	0	0	0	0	1	0	0	0	8997	855	30	2	43	2	LRIT1	10	85991723	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6206912	85991723	49543024	429	28276											
OPN4	94233	broad.mit.edu	37	chr10	88416025	88416025	+	Frame_Shift_Del	DEL	G	-	-																															gtgggactcacggggatgctGggcaacctgacggtcatcta																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:88416025delG	uc001kdq.2	+	2	485	c.258delG	c.(256-258)CTGfs	p.L86fs	OPN4_uc001kdp.2_Frame_Shift_Del_p.L86fs|OPN4_uc010qmk.1_Frame_Shift_Del_p.L86fs	NM_033282	NP_150598	Q9UHM6	OPN4_HUMAN	opsin 4 isoform 1	86	Helical; Name=1; (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			ovary(1)	1						CGGGGATGCTGGGCAACCTGA	0.617													---	---	---								-	88416025	-	-	88416025	7	5	154	1	0	1	0	1	0	0	0	0	10936	1335	47	0	264	0	OPN4	10	88416025	Frame_Shift_Del	DEL	G	TCGA-CR-7388-01A-11D-2012-08	2424302	88416025	47118722	430	28277											
C10orf12	26148	broad.mit.edu	37	chr10	98741788	98741788	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacactggccagaaatttacActcccaggaaaaagcaagct	16	7	7	11	0	0	1	0	0	0	1	1	2	1	2	2	2	4	2	2	2	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:98741788A>T	uc001kmv.2	+	1	748	c.641A>T	c.(640-642)CAC>CTC	p.H214L	C10orf12_uc009xvg.1_Missense_Mutation_p.H524L	NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	214										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AGAAATTTACACTCCCAGGAA	0.458													20	94					0	0	0	0	T	98741788	T	T	98741788	3	4	154	1	0	0	0	0	1	0	0	0	1595	159	6	5	643	5	C10orf12	10	98741788	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	10325763	98741788	36792959	431	28278											
DUSP5	1847	broad.mit.edu	37	chr10	112269778	112269778	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcttttcttccttccagActgtgtcagggaaaagggag	9	12	10	10	0	3	1	1	0	2	1	5	3	5	3	3	2	0	0	3	2	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:112269778A>T	uc001kzd.2	+	4	1004	c.749A>T	c.(748-750)GAC>GTC	p.D250V		NM_004419	NP_004410	Q16690	DUS5_HUMAN	dual specificity phosphatase 5	250	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1		Breast(234;0.0848)		Epithelial(162;0.000276)|all cancers(201;0.00465)|BRCA - Breast invasive adenocarcinoma(275;0.12)		TTCCTTCCAGACTGTGTCAGG	0.483													8	68					0	0	0	0	T	112269778	T	T	112269778	3	4	154	1	0	0	0	0	1	0	0	0	4850	289	10	5	763	5	DUSP5	10	112269778	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	13527990	112269778	23264969	432	28279											
TRUB1	142940	broad.mit.edu	37	chr10	116698023	116698023	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctacaaaagtatggccgcttCtgaggcggcggtggtgtctt	7	11	14	9	3	2	1	0	1	2	0	2	1	2	1	1	5	1	2	1	5	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:116698023C>G	uc001lcd.2	+	1	72	c.11C>G	c.(10-12)TCT>TGT	p.S4C	TRUB1_uc010qsl.1_Intron	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	4					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		ATGGCCGCTTCTGAGGCGGCG	0.572													5	51					0	0	0	0	G	116698023	G	G	116698023	3	3	154	1	0	0	0	0	1	0	0	0	16669	913	32	2	13	2	TRUB1	10	116698023	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4428245	116698023	18836724	433	28280											
ATRNL1	26033	broad.mit.edu	37	chr10	116853721	116853721	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaccggctcctgcttctCgggccgctgtgtcaactcca	5	9	12	15	3	2	0	1	0	1	0	5	2	4	1	4	3	2	3	4	3	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:116853721C>A	uc001lcg.2	+	1	598	c.212C>A	c.(211-213)TCG>TAG	p.S71*	ATRNL1_uc001lce.2_Intron|ATRNL1_uc001lcf.2_Nonsense_Mutation_p.S71*|ATRNL1_uc009xyq.2_Nonsense_Mutation_p.S71*	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	71	EGF-like 1.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TCCTGCTTCTCGGGCCGCTGT	0.662													7	20					0.00198382	0.003734	1	0	A	116853721	A	A	116853721	4	1	154	1	0	0	0	0	0	1	0	0	1209	893	31	3	214	3	ATRNL1	10	116853721	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	155698	116853721	18681026	434	28281											
PNLIPRP3	119548	broad.mit.edu	37	chr10	118196325	118196325	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttaccctggtctccagagaAgataaacactcgtttcctgc	10	12	7	12	1	1	2	0	0	1	2	4	3	2	2	3	1	3	1	3	1	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:118196325A>T	uc001lcl.3	+	2	253	c.152A>T	c.(151-153)AAG>ATG	p.K51M		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	51					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		TCTCCAGAGAAGATAAACACT	0.403													13	82					0	0	0	0	T	118196325	T	T	118196325	3	4	154	1	0	0	0	0	1	0	0	0	12207	72	3	5	158	5	PNLIPRP3	10	118196325	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	1342604	118196325	17338422	435	28282											
EIF3A	8661	broad.mit.edu	37	chr10	120809438	120809438	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taatttcttcacccgctcctGatactctcgtagctcttcct	6	16	4	15	2	4	1	1	1	3	0	7	1	6	1	3	0	2	3	3	0	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:120809438G>A	uc001ldu.2	-	17	2679	c.2533C>T	c.(2533-2535)CAG>TAG	p.Q845*	EIF3A_uc010qsu.1_Nonsense_Mutation_p.Q811*|EIF3A_uc009xzg.1_5'UTR	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	845	Glu-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		ACCCGCTCCTGATACTCTCGT	0.493													11	176					0	0	0	0	A	120809438	A	A	120809438	4	1	154	1	0	0	0	0	0	1	0	0	5034	1299	45	2	1639	2	EIF3A	10	120809438	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2613113	120809438	14725309	436	28283											
C10orf119	79892	broad.mit.edu	37	chr10	121618670	121618670	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttaggtttcaaataatgaagGggaacttcgttcagtgatgg	12	13	12	4	1	2	2	2	2	0	0	3	3	2	3	0	4	1	2	0	4	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:121618670G>T	uc001ler.2	-	3	466	c.168C>A	c.(166-168)CCC>CCA	p.P56P	C10orf119_uc001les.1_5'UTR	NM_024834	NP_079110	Q9BTE3	MCMBP_HUMAN	chromosome 10 open reading frame 119	56					cell division|DNA-dependent DNA replication|mitosis|S phase of mitotic cell cycle|sister chromatid cohesion	nucleus	chromatin binding				0		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.0044)		AATAATGAAGGGGAACTTCGT	0.328													11	29					6.40141e-05	0.000126162	1	0	T	121618670	T	T	121618670	2	4	154	1	0	0	0	0	0	0	0	1	1594	1219	43	4		4	C10orf119	10	121618670	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	809232	121618670	13916077	437	28284											
SEC23IP	11196	broad.mit.edu	37	chr10	121689212	121689212	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcactattcgaggagttGataggatagatgagaattac	13	13	10	5	1	1	3	1	2	1	2	3	7	1	5	0	2	1	1	0	2	5	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:121689212G>C	uc001leu.1	+	14	2479	c.2407G>C	c.(2407-2409)GAT>CAT	p.D803H	SEC23IP_uc010qtc.1_Missense_Mutation_p.D592H|SEC23IP_uc009xzk.1_RNA	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	803	DDHD.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TCGAGGAGTTGATAGGATAGA	0.353													4	115					0	0	0	0	C	121689212	C	C	121689212	3	2	154	1	0	0	0	0	1	0	0	0	14058	1290	45	2	2461	2	SEC23IP	10	121689212	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	70542	121689212	13845535	438	28285											
DOCK1	1793	broad.mit.edu	37	chr10	129179577	129179577	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgacctgcacaaggagtGtgataactacaccgaagcgg	12	7	12	10	2	0	2	0	2	0	0	0	4	0	3	2	2	4	1	2	2	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:129179577G>C	uc001ljt.2	+	37	3753	c.3689G>C	c.(3688-3690)TGT>TCT	p.C1230S	DOCK1_uc010qun.1_Missense_Mutation_p.C1251S|DOCK1_uc009yaq.2_Missense_Mutation_p.C225S	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1230	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CACAAGGAGTGTGATAACTAC	0.373													40	78					0	0	0	0	C	129179577	C	C	129179577	3	2	154	1	0	0	0	0	1	0	0	0	4706	1377	48	4	3835	4	DOCK1	10	129179577	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	7490365	129179577	6355170	439	28286											
MKI67	4288	broad.mit.edu	37	chr10	129906158	129906158	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caggtccagtttctgcactgGagttcccacaaatatgatga	11	11	9	10	0	1	2	0	2	1	0	3	3	3	3	2	2	1	3	2	2	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr10:129906158G>C	uc001lke.2	-	13	4141	c.3946C>G	c.(3946-3948)CCA>GCA	p.P1316A	MKI67_uc001lkf.2_Missense_Mutation_p.P956A|MKI67_uc009yav.1_Missense_Mutation_p.P891A|MKI67_uc009yaw.1_Missense_Mutation_p.P466A	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1316	16 X 122 AA approximate repeats.|3.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTCTGCACTGGAGTTCCCACA	0.507													23	275					0	0	0	0	C	129906158	C	C	129906158	3	2	154	1	0	0	0	0	1	0	0	0	9651	1174	41	2	5836	2	MKI67	10	129906158	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	726581	129906158	5628589	440	28287											
LRRC56	115399	broad.mit.edu	37	chr11	549902	549902	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccaaaccctgccttctgcagGgacttgggcacgtctctggg	6	9	12	14	1	2	0	0	0	2	0	3	1	2	1	3	3	3	2	3	3	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:549902G>T	uc010qvz.1	+	7	832	c.327G>T	c.(325-327)AGG>AGT	p.R109S		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	109	LRR 1.									skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCTTCTGCAGGGACTTGGGCA	0.627													12	31					7.03913e-09	1.52024e-08	1	0	T	549902	T	T	549902	3	4	154	1	0	0	0	0	1	0	0	0	9062	1246	43	4	341	4	LRRC56	11	549902	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08		549902	134456614	441	28288											
EPS8L2	64787	broad.mit.edu	37	chr11	722485	722485	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgccgtggacttcctgcgcGgccacctggtccctaaggag	6	8	13	14	3	0	0	0	0	0	0	2	2	2	2	5	4	2	0	5	4	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:722485G>A	uc001lqt.2	+	13	1391	c.1144G>A	c.(1144-1146)GGC>AGC	p.G382S	EPS8L2_uc001lqu.2_Missense_Mutation_p.G382S|EPS8L2_uc010qwk.1_Missense_Mutation_p.G398S|EPS8L2_uc001lqv.2_Missense_Mutation_p.G337S|EPS8L2_uc001lqw.2_5'UTR|EPS8L2_uc001lqx.2_5'UTR|EPS8L2_uc001lqy.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	382						cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTTCCTGCGCGGCCACCTGGT	0.662													9	31					0	0	0	0	A	722485	A	A	722485	3	1	154	1	0	0	0	0	1	0	0	0	5220	1116	39	1	1190	1	EPS8L2	11	722485	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	172583	722485	134284031	442	28289											
TRIM6-TRIM34	445372	broad.mit.edu	37	chr11	5656091	5656091	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaacaatggagctgctgcaGgtaagaaggttcgctcaatc	12	9	11	9	1	2	1	2	0	0	1	4	2	2	2	0	3	4	6	0	3	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:5656091G>C	uc001mbf.2	+	10	2056	c.1812G>C	c.(1810-1812)CAG>CAC	p.Q604H	HBG2_uc001mak.1_Intron|TRIM34_uc001mbh.2_Missense_Mutation_p.Q250H|TRIM34_uc009yeq.2_Missense_Mutation_p.Q5H|TRIM34_uc001mbi.2_Missense_Mutation_p.Q250H|TRIM34_uc001mbj.2_Missense_Mutation_p.Q250H	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	604						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		AGCTGCTGCAGGTAAGAAGGT	0.517													7	19					0	0	0	0	C	5656091	C	C	5656091	3	2	154	1	0	0	0	0	1	0	0	0	16601	1014	35	4	1850	4	TRIM6-TRIM34	11	5656091	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4933606	5656091	129350425	443	28290											
TRIM22	10346	broad.mit.edu	37	chr11	5717502	5717502	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagacatagagaaggaggtgAcctgccccatctgcctggag	11	7	13	10	0	1	3	0	1	1	2	1	6	1	5	4	3	2	0	4	3	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:5717502A>T	uc001mbr.2	+	2	317	c.40A>T	c.(40-42)ACC>TCC	p.T14S	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Missense_Mutation_p.T14S|TRIM22_uc009yes.2_Missense_Mutation_p.T14S|TRIM22_uc010qzm.1_5'UTR|TRIM22_uc009yeu.2_5'UTR	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	14					immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		GAAGGAGGTGACCTGCCCCAT	0.507													16	46					0	0	0	0	T	5717502	T	T	5717502	3	4	154	1	0	0	0	0	1	0	0	0	16563	275	10	5	42	5	TRIM22	11	5717502	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	61411	5717502	129289014	444	28291											
OR56B4	196335	broad.mit.edu	37	chr11	6129218	6129218	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatgtaccatttgctgggCatattagcagtggtggacat	9	12	11	9	0	0	0	0	0	0	0	0	1	0	1	2	3	3	4	2	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:6129218C>A	uc010qzx.1	+	1	210	c.210C>A	c.(208-210)GGC>GGA	p.G70G		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTTGCTGGGCATATTAGCAG	0.502													11	34					3.86212e-05	7.65457e-05	1	0	A	6129218	A	A	6129218	2	1	154	1	0	0	0	0	0	0	0	1	11192	697	25	4		4	OR56B4	11	6129218	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	411716	6129218	128877298	445	28292											
SYT9	143425	broad.mit.edu	37	chr11	7437333	7437333	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttccaacggctggcaggCtgaccattaccattataaaa	13	10	7	11	1	1	1	0	1	1	0	2	1	2	1	3	3	2	3	3	3	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:7437333C>A	uc001mfe.2	+	4	1342	c.1105C>A	c.(1105-1107)CTG>ATG	p.L369M	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	369	Cytoplasmic (Potential).|C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GGCTGGCAGGCTGACCATTAC	0.433													22	46					1.10923e-09	2.45287e-09	1	0	A	7437333	A	A	7437333	3	1	154	1	0	0	0	0	1	0	0	0	15547	796	28	4	1119	4	SYT9	11	7437333	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1308115	7437333	127569183	446	28293											
ST5	6764	broad.mit.edu	37	chr11	8724239	8724239	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtccacgtgctccagccttGagtccatgggccgccgcagc	6	7	12	16	3	0	1	0	1	0	0	3	1	3	1	6	1	3	2	6	1	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:8724239G>A	uc001mgt.2	-	14	2786	c.2600C>T	c.(2599-2601)TCA>TTA	p.S867L	ST5_uc009yfr.2_Missense_Mutation_p.S447L|ST5_uc001mgu.2_Missense_Mutation_p.S447L|ST5_uc001mgv.2_Missense_Mutation_p.S867L|ST5_uc010rbp.1_Missense_Mutation_p.S380L|ST5_uc009yfs.2_RNA	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	867	DENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CTCCAGCCTTGAGTCCATGGG	0.622													9	50					0	0	0	0	A	8724239	A	A	8724239	3	1	154	1	0	0	0	0	1	0	0	0	15286	1294	45	2	841	2	ST5	11	8724239	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1286906	8724239	126282277	447	28294											
SCUBE2	57758	broad.mit.edu	37	chr11	9090930	9090930	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacttacagatgcagtctctCtggttcttggccagctcaaa	9	13	8	11	0	4	1	1	0	3	1	5	1	4	1	1	2	4	3	1	2	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:9090930C>T	uc001mhh.1	-	5	710	c.630G>A	c.(628-630)CAG>CAA	p.Q210Q	SCUBE2_uc001mhi.1_Silent_p.Q210Q|SCUBE2_uc001mhj.1_Silent_p.Q210Q	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	210	EGF-like 4 (Potential).					extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		TGCAGTCTCTCTGGTTCTTGG	0.577													20	67					0	0	0	0	T	9090930	T	T	9090930	2	4	154	1	0	0	0	0	0	0	0	1	14010	912	32	2		2	SCUBE2	11	9090930	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	366691	9090930	125915586	448	28295											
KCNC1	3746	broad.mit.edu	37	chr11	17793800	17793800	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcacacgcactttaagaacAtccccatcggcttctggtgg	10	9	9	13	2	1	1	0	0	1	1	3	1	2	1	2	3	2	3	2	3	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:17793800A>T	uc001mnk.3	+	2	1214	c.1159A>T	c.(1159-1161)ATC>TTC	p.I387F	KCNC1_uc009yhc.1_Missense_Mutation_p.I387F	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	387						voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						CTTTAAGAACATCCCCATCGG	0.612													24	57					0	0	0	0	T	17793800	T	T	17793800	3	4	154	1	0	0	0	0	1	0	0	0	8053	217	8	5	1165	5	KCNC1	11	17793800	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	8702870	17793800	117212716	449	28296											
AMBRA1	55626	broad.mit.edu	37	chr11	46564192	46564192	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagtgtacacagatgcctGagagccaccttcctgctgtc	9	10	10	12	0	0	3	0	2	0	2	2	4	1	3	4	0	4	2	4	0	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:46564192G>A	uc010rgu.1	-	7	1735	c.1375C>T	c.(1375-1377)CAG>TAG	p.Q459*	AMBRA1_uc010rgt.1_Nonsense_Mutation_p.Q25*|AMBRA1_uc009ylc.1_Nonsense_Mutation_p.Q459*|AMBRA1_uc001ncu.1_Nonsense_Mutation_p.Q369*|AMBRA1_uc001ncv.2_Nonsense_Mutation_p.Q369*|AMBRA1_uc001ncw.2_Nonsense_Mutation_p.Q369*|AMBRA1_uc001ncx.2_Nonsense_Mutation_p.Q459*	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	459					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		ACAGATGCCTGAGAGCCACCT	0.572													10	49					0	0	0	0	A	46564192	A	A	46564192	4	1	154	1	0	0	0	0	0	1	0	0	565	1299	45	2	2569	2	AMBRA1	11	46564192	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	28770392	46564192	88442324	450	28297											
CKAP5	9793	broad.mit.edu	37	chr11	46772905	46772905	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcttactcaccttgggcccTtttaatttgcataaggtgtg	7	17	8	9	0	2	0	1	0	1	0	2	0	2	0	2	2	2	1	2	2	3	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:46772905T>C	uc001ndi.1	-	39	5423	c.5313A>G	c.(5311-5313)AAA>AAG	p.K1771K	CKAP5_uc009ylg.1_Silent_p.K1657K|CKAP5_uc001ndj.1_Silent_p.K1711K|CKAP5_uc001ndh.1_Silent_p.K700K	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1771					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CCTTGGGCCCTTTTAATTTGC	0.443													3	120					0	0	0	0	C	46772905	C	C	46772905	2	2	154	1	0	0	0	0	0	0	0	1	3460	1606	56	5		5	CKAP5	11	46772905	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	208713	46772905	88233611	451	28298											
OR4C3	256144	broad.mit.edu	37	chr11	48346907	48346907	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggaggtgttgagatcattCtgctcacagtgatggcttat	8	14	13	6	0	3	2	2	2	1	1	3	4	3	3	0	3	1	3	0	3	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:48346907C>T	uc010rhv.1	+	1	415	c.415C>T	c.(415-417)CTG>TTG	p.L139L		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGAGATCATTCTGCTCACAGT	0.488													31	139					0	0	0	0	T	48346907	T	T	48346907	2	4	154	1	0	0	0	0	0	0	0	1	11104	912	32	2		2	OR4C3	11	48346907	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1574002	48346907	86659609	452	28299											
OR4C11	219429	broad.mit.edu	37	chr11	55371370	55371370	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaaggcaatcttaaggcCaggataatctgagctgtaga	15	8	11	7	0	2	3	0	1	2	2	2	4	2	4	1	3	1	3	1	3	5	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:55371370C>A	uc010rii.1	-	1	480	c.480G>T	c.(478-480)CTG>CTT	p.L160L		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	160	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCTTAAGGCCAGGATAATCT	0.448													20	65					2.39187e-15	5.72876e-15	1	0	A	55371370	A	A	55371370	2	1	154	1	0	0	0	0	0	0	0	1	11099	581	21	4		4	OR4C11	11	55371370	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	7024463	55371370	79635146	453	28300											
OR4S2	219431	broad.mit.edu	37	chr11	55419152	55419152	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtacttttatgtacatgcGccctgatacgaccttttcag	8	15	7	11	2	1	1	1	1	0	0	1	2	1	1	2	0	4	2	2	0	4	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:55419152G>T	uc001nhs.1	+	1	773	c.773G>T	c.(772-774)CGC>CTC	p.R258L		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				ATGTACATGCGCCCTGATACG	0.463													29	157					5.61819e-17	1.3567e-16	1	0	T	55419152	T	T	55419152	3	4	154	1	0	0	0	0	1	0	0	0	11137	1087	38	3	775	3	OR4S2	11	55419152	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	47782	55419152	79587364	454	28301											
OR5D13	390142	broad.mit.edu	37	chr11	55541290	55541290	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggcttatgaccgttttgTggcagtttgtaaacccttgc	7	15	11	8	1	0	1	0	1	0	0	0	2	0	1	2	2	2	5	2	2	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:55541290T>G	uc010ril.1	+	1	377	c.377T>G	c.(376-378)GTG>GGG	p.V126G		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				GACCGTTTTGTGGCAGTTTGT	0.448													37	182					0	0	0	0	G	55541290	G	G	55541290	3	3	154	1	0	0	0	0	1	0	0	0	11208	1696	59	5	379	5	OR5D13	11	55541290	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	122138	55541290	79465226	455	28302											
OR10AG1	282770	broad.mit.edu	37	chr11	55735663	55735663	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaagcataagaaaaaaacAcatttgtgtagcacaagcaa	20	7	6	8	0	0	1	0	0	0	1	1	1	1	1	1	0	4	4	1	0	8	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:55735663A>T	uc010rit.1	-	1	277	c.277T>A	c.(277-279)TGT>AGT	p.C93S		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	93	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					AGAAAAAAACACATTTGTGTA	0.403													10	59					0	0	0	0	T	55735663	T	T	55735663	3	4	154	1	0	0	0	0	1	0	0	0	10951	159	6	5	631	5	OR10AG1	11	55735663	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	194373	55735663	79270853	456	28303											
OR8H2	390151	broad.mit.edu	37	chr11	55873233	55873233	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaaagcagaaagctttcTctacttgcgtctctcatctc	10	12	7	12	1	4	1	1	0	3	1	7	2	4	2	0	1	4	2	0	1	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:55873233T>A	uc010riy.1	+	1	715	c.715T>A	c.(715-717)TCT>ACT	p.S239T		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	239	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					GAAAGCTTTCTCTACTTGCGT	0.383										HNSCC(53;0.14)			19	65					0	0	0	0	A	55873233	A	A	55873233	3	1	154	1	0	0	0	0	1	0	0	0	11292	1551	54	5	717	5	OR8H2	11	55873233	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	137570	55873233	79133283	457	28304											
OR5T2	219464	broad.mit.edu	37	chr11	56000129	56000129	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgagtggcatgtagactCtgggtgacatgctcactgaa	10	11	13	7	0	2	5	1	4	1	1	2	5	2	5	0	2	1	3	0	2	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:56000129C>A	uc010rjc.1	-	1	533	c.533G>T	c.(532-534)AGA>ATA	p.R178I		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	178	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CATGTAGACTCTGGGTGACAT	0.443													25	103					3.08376e-08	6.5952e-08	1	0	A	56000129	A	A	56000129	3	1	154	1	0	0	0	0	1	0	0	0	11236	913	32	2	545	2	OR5T2	11	56000129	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	126896	56000129	79006387	458	28305											
OR5T3	390154	broad.mit.edu	37	chr11	56019731	56019731	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcaagtaaaaactgaaaTggacaagttgtcatcaggtt	15	10	9	7	0	2	1	2	1	0	0	2	2	2	2	1	2	2	4	1	2	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:56019731T>A	uc010rjd.1	+	1	56	c.56T>A	c.(55-57)ATG>AAG	p.M19K		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					AAAACTGAAATGGACAAGTTG	0.368													5	37					0	0	0	0	A	56019731	A	A	56019731	3	1	154	1	0	0	0	0	1	0	0	0	11237	1464	51	5	58	5	OR5T3	11	56019731	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	19602	56019731	78986785	459	28306											
OR5T3	390154	broad.mit.edu	37	chr11	56020312	56020312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgtcttttgtgatatgcctCctctccttgctatttcttgt	4	21	6	10	0	3	1	0	1	3	0	5	1	4	1	3	0	2	1	3	0	2	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:56020312C>T	uc010rjd.1	+	1	637	c.637C>T	c.(637-639)CCT>TCT	p.P213S		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	213	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TGATATGCCTCCTCTCCTTGC	0.408													6	219					0	0	0	0	T	56020312	T	T	56020312	3	4	154	1	0	0	0	0	1	0	0	0	11237	855	30	2	639	2	OR5T3	11	56020312	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	581	56020312	78986204	460	28307											
OR8K3	219473	broad.mit.edu	37	chr11	56086553	56086553	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatgggactttgcttttcatGtacgtgcagcccaagtccag	8	13	10	10	1	1	0	1	0	0	0	2	1	2	1	2	1	4	3	2	1	3	5	rs150576458	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:56086553G>T	uc010rjf.1	+	1	771	c.771G>T	c.(769-771)ATG>ATT	p.M257I		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TGCTTTTCATGTACGTGCAGC	0.448													9	57					5.4927e-09	1.18918e-08	1	0	T	56086553	T	T	56086553	3	4	154	1	0	0	0	0	1	0	0	0	11298	1377	48	4	773	4	OR8K3	11	56086553	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	66241	56086553	78919963	461	28308											
TNKS1BP1	85456	broad.mit.edu	37	chr11	57077033	57077033	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacctcctggctagcatcaCtgttttgccagctgctctgg	5	12	9	15	0	2	0	1	0	1	0	3	0	3	0	4	2	4	5	4	2	1	3	rs141886247	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:57077033C>A	uc001njr.2	-	5	3464	c.3152G>T	c.(3151-3153)AGT>ATT	p.S1051I	TNKS1BP1_uc001njs.2_Missense_Mutation_p.S1051I|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.S502I	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1051	Gly-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				GCTAGCATCACTGTTTTGCCA	0.637													24	56					9.86323e-18	2.38837e-17	1	0	A	57077033	A	A	57077033	3	1	154	1	0	0	0	0	1	0	0	0	16386	565	20	4	2061	4	TNKS1BP1	11	57077033	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	990480	57077033	77929483	462	28309											
OR9Q1	219956	broad.mit.edu	37	chr11	57947762	57947762	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttacacagaggtcatcccCatgttgaatcccctcatcta	10	12	5	14	0	3	2	2	1	1	1	5	2	5	2	4	1	1	1	4	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:57947762C>A	uc001nmj.2	+	3	1162	c.846C>A	c.(844-846)CCC>CCA	p.P282P		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				AGGTCATCCCCATGTTGAATC	0.458													27	61					1.2476e-16	3.00861e-16	1	0	A	57947762	A	A	57947762	2	1	154	1	0	0	0	0	0	0	0	1	11309	581	21	4		4	OR9Q1	11	57947762	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	870729	57947762	77058754	463	28310											
OR10Q1	219960	broad.mit.edu	37	chr11	57996165	57996165	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gacaggaagaaatacatcggGgtgcggagggtgctgtgtgt	10	8	18	5	2	0	1	0	0	0	1	1	4	0	3	0	5	3	1	0	5	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:57996165G>C	uc010rkd.1	-	1	183	c.183C>G	c.(181-183)ACC>ACG	p.T61T		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				AATACATCGGGGTGCGGAGGG	0.527													9	73					0	0	0	0	C	57996165	C	C	57996165	2	2	154	1	0	0	0	0	0	0	0	1	10970	1219	43	4		4	OR10Q1	11	57996165	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	48403	57996165	77010351	464	28311											
OR5A2	219981	broad.mit.edu	37	chr11	59190214	59190214	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggaggacacatagcagatGtccaggaaggacaggttact	13	7	14	7	0	0	1	0	0	0	1	1	5	1	5	1	5	2	2	1	5	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:59190214G>T	uc010rkt.1	-	1	213	c.213C>A	c.(211-213)GAC>GAA	p.D71E		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATAGCAGATGTCCAGGAAGG	0.493													21	70					1.28384e-07	2.70622e-07	1	0	T	59190214	T	T	59190214	3	4	154	1	0	0	0	0	1	0	0	0	11194	1368	48	4	763	4	OR5A2	11	59190214	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1194049	59190214	75816302	465	28312											
MS4A14	84689	broad.mit.edu	37	chr11	60170499	60170499	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgccagatgccatcctttGaagaaatatgtgttttcagt	11	14	8	8	0	1	3	1	1	0	2	2	3	2	3	3	0	2	1	3	0	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:60170499G>C	uc001npj.2	+	4	998	c.433G>C	c.(433-435)GAA>CAA	p.E145Q	MS4A14_uc001npi.2_Missense_Mutation_p.E33Q|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.E128Q|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	145	Helical; (Potential).					integral to membrane	receptor activity			breast(1)	1						GCCATCCTTTGAAGAAATATG	0.388													5	119					0	0	0	0	C	60170499	C	C	60170499	3	2	154	1	0	0	0	0	1	0	0	0	9911	1291	45	2	447	2	MS4A14	11	60170499	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	980285	60170499	74836017	466	28313											
AHNAK	79026	broad.mit.edu	37	chr11	62293302	62293302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttcaggacctttcagatCtccctctaccttagggcctg	8	12	7	14	0	4	1	2	0	2	1	5	2	4	2	4	2	2	0	4	2	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:62293302C>T	uc001ntl.2	-	5	8887	c.8587G>A	c.(8587-8589)GAT>AAT	p.D2863N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2863					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCTTTCAGATCTCCCTCTACC	0.453													16	165					0	0	0	0	T	62293302	T	T	62293302	3	4	154	1	0	0	0	0	1	0	0	0	414	913	32	2	9205	2	AHNAK	11	62293302	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2122803	62293302	72713214	467	28314											
INTS5	80789	broad.mit.edu	37	chr11	62415040	62415040	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcccgctccacggtggcccGggcgtgttcctcggggggcc	2	7	16	16	5	0	0	0	0	0	0	4	0	3	0	5	6	0	2	5	6	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:62415040G>C	uc001nud.2	-	2	2565	c.2512C>G	c.(2512-2514)CGG>GGG	p.R838G	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	838					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						ACGGTGGCCCGGGCGTGTTCC	0.657													3	103					0	0	0	0	C	62415040	C	C	62415040	3	2	154	1	0	0	0	0	1	0	0	0	7820	1115	39	3	551	3	INTS5	11	62415040	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	121738	62415040	72591476	468	28315											
SNX32	254122	broad.mit.edu	37	chr11	65617935	65617935	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atctttaagaagacagttgcGatgcacgaagtctttctgca	12	12	9	8	2	3	2	0	0	3	2	3	4	3	2	0	0	3	3	0	0	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:65617935G>A	uc001ofr.2	+	5	535	c.408G>A	c.(406-408)GCG>GCA	p.A136A	SNX32_uc010rop.1_3'UTR	NM_152760	NP_689973	Q86XE0	SNX32_HUMAN	sorting nexin 6B	136	PX.				cell communication|protein transport		phosphatidylinositol binding				0				READ - Rectum adenocarcinoma(159;0.171)		AGACAGTTGCGATGCACGAAG	0.592													6	57					0	0	0	0	A	65617935	A	A	65617935	2	1	154	1	0	0	0	0	0	0	0	1	14966	1045	37	1		1	SNX32	11	65617935	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3202895	65617935	69388581	469	28316											
CATSPER1	117144	broad.mit.edu	37	chr11	65793167	65793167	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgggcttcatgatgacgggaCctgccatggtggtggacttg	6	11	16	8	1	1	2	1	2	0	0	1	4	1	4	2	5	1	1	2	5	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:65793167C>A	uc001ogt.2	-	1	822	c.684G>T	c.(682-684)AGG>AGT	p.R228S		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	228	His-rich.|Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						GATGACGGGACCTGCCATGGT	0.592													13	33					3.27435e-08	6.9943e-08	1	0	A	65793167	A	A	65793167	3	1	154	1	0	0	0	0	1	0	0	0	2699	506	18	4	1706	4	CATSPER1	11	65793167	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	175232	65793167	69213349	470	28317											
TCIRG1	10312	broad.mit.edu	37	chr11	67812468	67812468	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctcaccgcatcccctgccGggacatgccccccacactca	7	5	8	21	2	2	0	2	0	0	0	3	1	3	1	7	2	2	2	7	2	0	0	rs148627120	by1000genomes	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:67812468G>T	uc001one.2	+	10	1172	c.1064G>T	c.(1063-1065)CGG>CTG	p.R355L	TCIRG1_uc001ong.2_Missense_Mutation_p.R139L|TCIRG1_uc001onh.2_Missense_Mutation_p.R57L|TCIRG1_uc001oni.2_5'UTR	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	355	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						ATCCCCTGCCGGGACATGCCC	0.682													10	46					1.58986e-06	3.28435e-06	1	0	T	67812468	T	T	67812468	3	4	154	1	0	0	0	0	1	0	0	0	15769	1116	39	3	1098	3	TCIRG1	11	67812468	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2019301	67812468	67194048	471	28318											
MYEOV	26579	broad.mit.edu	37	chr11	69063361	69063361	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcactctgtgtggcactggGaacaggaattctgggagtca	9	9	15	8	0	3	0	1	0	2	0	3	3	3	3	0	5	1	2	0	5	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:69063361G>T	uc001oov.2	+	3	894	c.444G>T	c.(442-444)GGG>GGT	p.G148G	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Silent_p.G148G|MYEOV_uc001oow.2_Silent_p.G90G	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	148											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		GTGGCACTGGGAACAGGAATT	0.622													16	330					4.75885e-15	1.13515e-14	1	0	T	69063361	T	T	69063361	2	4	154	1	0	0	0	0	0	0	0	1	10078	1161	41	2		2	MYEOV	11	69063361	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1250893	69063361	65943155	472	28319											
USP35	57558	broad.mit.edu	37	chr11	77909074	77909074	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggaacctcagcaatgatGacagtgtgacagactcgcag	12	7	11	11	2	1	4	1	3	0	1	3	5	2	5	2	1	2	2	2	1	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:77909074G>T	uc009yva.1	+	3	1012	c.766G>T	c.(766-768)GAC>TAC	p.D256Y	USP35_uc001oze.2_Missense_Mutation_p.D12Y|USP35_uc001ozc.2_Intron|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_5'UTR|USP35_uc001ozf.2_5'Flank	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	256					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CAGCAATGATGACAGTGTGAC	0.597													7	116					0.000274275	0.000530446	1	0	T	77909074	T	T	77909074	3	4	154	1	0	0	0	0	1	0	0	0	17134	1290	45	2	772	2	USP35	11	77909074	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	8845713	77909074	57097442	473	28320											
ODZ4	26011	broad.mit.edu	37	chr11	78413272	78413272	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gactccagggttgcgtggatGgccaccttgcttagcaggaa	8	9	14	10	1	0	0	0	0	0	0	1	3	1	2	3	4	3	3	3	4	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:78413272G>T	uc001ozl.3	-	28	4849	c.4386C>A	c.(4384-4386)GCC>GCA	p.A1462A	ODZ4_uc009yvb.1_Silent_p.A46A	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1462	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TTGCGTGGATGGCCACCTTGC	0.552													11	32					2.80697e-09	6.14528e-09	1	0	T	78413272	T	T	78413272	2	4	154	1	0	0	0	0	0	0	0	1	10891	1335	47	4		4	ODZ4	11	78413272	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	504198	78413272	56593244	474	28321											
CREBZF	58487	broad.mit.edu	37	chr11	85375815	85375815	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccccgctgcagcccgggtCaggtcagagggcagcgaaca	8	4	14	15	3	2	1	2	0	0	1	3	2	3	1	3	3	4	3	3	3	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:85375815C>G	uc001pas.2	-	1	368	c.105G>C	c.(103-105)CTG>CTC	p.L35L	CREBZF_uc010rtc.1_RNA|CREBZF_uc010rtd.1_RNA	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	35					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				CAGCCCGGGTCAGGTCAGAGG	0.692													4	38					0	0	0	0	G	85375815	G	G	85375815	2	3	154	1	0	0	0	0	0	0	0	1	3878	813	29	2		2	CREBZF	11	85375815	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6962543	85375815	49630701	475	28322											
CTSC	1075	broad.mit.edu	37	chr11	88027277	88027277	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cattctcaccccagccggtgCcccagctgtttttaacaatc	8	11	6	16	1	1	0	1	0	1	0	3	0	1	0	5	1	4	2	5	1	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:88027277C>A	uc001pck.3	-	7	1390	c.1289G>T	c.(1288-1290)GGC>GTC	p.G430V	CTSC_uc001pcl.3_Missense_Mutation_p.G282V	NM_001814	NP_001805	P53634	CATC_HUMAN	cathepsin C isoform a preproprotein	430					immune response	lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCAGCCGGTGCCCCAGCTGTT	0.507													10	63					3.07112e-06	6.27794e-06	1	0	A	88027277	A	A	88027277	3	1	154	1	0	0	0	0	1	0	0	0	4048	739	26	4	106	4	CTSC	11	88027277	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2651462	88027277	46979239	476	28323											
TYR	7299	broad.mit.edu	37	chr11	88911881	88911881	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcacagatgagtacatgggaGgtcagcaccccacaaatcct	13	6	10	12	0	1	2	1	1	0	1	2	3	2	3	3	2	2	3	3	2	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:88911881G>C	uc001pcs.2	+	1	842	c.760G>C	c.(760-762)GGT>CGT	p.G254R		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	254	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	GTACATGGGAGGTCAGCACCC	0.458									Oculocutaneous_Albinism				19	51					0	0	0	0	C	88911881	C	C	88911881	3	2	154	1	0	0	0	0	1	0	0	0	16881	1000	35	4	762	4	TYR	11	88911881	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	884604	88911881	46094635	477	28324											
FAT3	120114	broad.mit.edu	37	chr11	92523337	92523337	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcgtgctctatactgccGagaggctggaccatgaggcc	7	8	14	12	2	1	2	0	1	1	1	1	4	1	3	3	4	3	2	3	4	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:92523337G>T	uc001pdj.3	+	7	4581	c.4564G>T	c.(4564-4566)GAG>TAG	p.E1522*		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1522	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTATACTGCCGAGAGGCTGGA	0.498										TCGA Ovarian(4;0.039)			53	142					9.86064e-34	2.45887e-33	1	0	T	92523337	T	T	92523337	4	4	154	1	0	0	0	0	0	1	0	0	5723	1059	37	3	4590	3	FAT3	11	92523337	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3611456	92523337	42483179	478	28325											
CCDC67	159989	broad.mit.edu	37	chr11	93088643	93088643	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgcgggctttggagacaCgattagatcttcgggatcaa	11	10	13	7	3	2	3	1	0	1	3	3	6	2	4	0	3	1	1	0	3	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:93088643C>T	uc001pdq.2	+	3	236	c.136C>T	c.(136-138)CGA>TGA	p.R46*	CCDC67_uc001pdo.1_Nonsense_Mutation_p.R46*|CCDC67_uc001pdp.2_Nonsense_Mutation_p.R46*	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	46	Potential.									ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TTTGGAGACACGATTAGATCT	0.388													16	48					0	0	0	0	T	93088643	T	T	93088643	4	4	154	1	0	0	0	0	0	1	0	0	2852	528	19	1	142	1	CCDC67	11	93088643	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	565306	93088643	41917873	479	28326											
HSPA8	3312	broad.mit.edu	37	chr11	122931384	122931384	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggatagaagcttttggtctCtcccttgtattctacttgga	7	17	9	8	0	2	1	0	0	2	1	4	3	3	3	1	3	2	2	1	3	4	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:122931384C>G	uc001pyo.2	-	3	406	c.328G>C	c.(328-330)GAG>CAG	p.E110Q	HSPA8_uc009zbc.2_5'Flank|HSPA8_uc001pyp.2_Missense_Mutation_p.E110Q|HSPA8_uc010rzu.1_Intron|HSPA8_uc009zbd.1_Missense_Mutation_p.E110Q|HSPA8_uc010rzv.1_Missense_Mutation_p.E110Q	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	110					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CTTTTGGTCTCTCCCTTGTAT	0.453													8	78					0	0	0	0	G	122931384	G	G	122931384	3	3	154	1	0	0	0	0	1	0	0	0	7455	922	32	2	1640	2	HSPA8	11	122931384	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	29842741	122931384	12075132	480	28327											
OR8A1	390275	broad.mit.edu	37	chr11	124440565	124440565	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtgacatcctccctctcAtgaagctgtcctgctctagc	6	13	7	15	0	3	2	1	2	3	0	7	2	6	2	3	0	3	2	3	0	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr11:124440565A>T	uc010san.1	+	1	601	c.601A>T	c.(601-603)ATG>TTG	p.M201L		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	201	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		CCTCCCTCTCATGAAGCTGTC	0.448													22	76					0	0	0	0	T	124440565	T	T	124440565	3	4	154	1	0	0	0	0	1	0	0	0	11279	217	8	5	603	5	OR8A1	11	124440565	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	1509181	124440565	10565951	481	28328											
WNK1	65125	broad.mit.edu	37	chr12	994586	994586	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atctcatagcagtacaactgGattggctttctccctctctg	8	14	7	12	0	3	0	1	0	3	0	6	1	3	1	1	2	3	3	1	2	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:994586G>C	uc001qio.3	+	19	5123	c.4616G>C	c.(4615-4617)GGA>GCA	p.G1539A	WNK1_uc001qip.3_Missense_Mutation_p.G1292A|WNK1_uc001qir.3_Missense_Mutation_p.G712A	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1539					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			AGTACAACTGGATTGGCTTTC	0.473													90	375					0	0	0	0	C	994586	C	C	994586	3	2	154	1	0	0	0	0	1	0	0	0	17445	1174	41	2	6192	2	WNK1	12	994586	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08		994586	132857309	482	28329											
CACNA1C	775	broad.mit.edu	37	chr12	2602389	2602389	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agatgacccttccccttgtgCgctggaaacgggccacgggc	7	7	13	14	3	0	2	0	1	0	1	1	3	1	3	4	3	2	1	4	3	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:2602389C>T	uc009zdu.1	+	7	1263	c.950C>T	c.(949-951)GCG>GTG	p.A317V	CACNA1C_uc009zdv.1_Missense_Mutation_p.A314V|CACNA1C_uc001qkb.2_Missense_Mutation_p.A317V|CACNA1C_uc001qkc.2_Missense_Mutation_p.A317V|CACNA1C_uc001qke.2_Missense_Mutation_p.A317V|CACNA1C_uc001qkf.2_Missense_Mutation_p.A317V|CACNA1C_uc001qjz.2_Missense_Mutation_p.A317V|CACNA1C_uc001qkd.2_Missense_Mutation_p.A317V|CACNA1C_uc001qkg.2_Missense_Mutation_p.A317V|CACNA1C_uc009zdw.1_Missense_Mutation_p.A317V|CACNA1C_uc001qkh.2_Missense_Mutation_p.A317V|CACNA1C_uc001qkl.2_Missense_Mutation_p.A317V|CACNA1C_uc001qkn.2_Missense_Mutation_p.A317V|CACNA1C_uc001qko.2_Missense_Mutation_p.A317V|CACNA1C_uc001qkp.2_Missense_Mutation_p.A317V|CACNA1C_uc001qkr.2_Missense_Mutation_p.A317V|CACNA1C_uc001qku.2_Missense_Mutation_p.A317V|CACNA1C_uc001qkq.2_Missense_Mutation_p.A317V|CACNA1C_uc001qks.2_Missense_Mutation_p.A317V|CACNA1C_uc001qkt.2_Missense_Mutation_p.A317V|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_Missense_Mutation_p.A53V|CACNA1C_uc001qkj.1_Missense_Mutation_p.A53V|CACNA1C_uc001qkk.1_Missense_Mutation_p.A53V|CACNA1C_uc001qkm.1_Missense_Mutation_p.A53V	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	317	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCCCCTTGTGCGCTGGAAACG	0.592													19	75					0	0	0	0	T	2602389	T	T	2602389	3	4	154	1	0	0	0	0	1	0	0	0	2552	768	27	1	976	1	CACNA1C	12	2602389	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1607803	2602389	131249506	483	28330											
KCNA5	3741	broad.mit.edu	37	chr12	5154004	5154004	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaagcccctgccccgcaacGagttccagcgccaggtgtgg	8	5	13	15	3	0	1	0	0	0	1	1	2	1	1	6	2	4	2	6	2	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:5154004G>A	uc001qni.2	+	1	920	c.691G>A	c.(691-693)GAG>AAG	p.E231K		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	231						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						GCCCCGCAACGAGTTCCAGCG	0.602													17	101					0	0	0	0	A	5154004	A	A	5154004	3	1	154	1	0	0	0	0	1	0	0	0	8045	1059	37	1	693	1	KCNA5	12	5154004	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2551615	5154004	128697891	484	28331											
LEPREL2	10536	broad.mit.edu	37	chr12	6939088	6939088	+	Silent	SNP	G	C	C																															gtagcaaaccccatgcacctGcagatgcgggaggacatggc																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:6939088G>C	uc001qra.1	+	4	598	c.564G>C	c.(562-564)CTG>CTC	p.L188L	LEPREL2_uc001qqz.1_5'UTR|LEPREL2_uc001qrb.1_5'UTR|GPR162_uc001qqy.1_Silent_p.L123L	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	188					negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CCATGCACCTGCAGATGCGGG	0.602													28	95					0	0	0	0	C	6939088	C	C	6939088	2	2	154	1	0	0	0	0	0	0	0	1	8771	1306	46	4		4	LEPREL2	12	6939088	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1785084	6939088	126912807	485	28332	56	2									
LEPREL2	10536	broad.mit.edu	37	chr12	6939090	6939090	+	Missense_Mutation	SNP	A	T	T																															agcaaaccccatgcacctgcAgatgcgggaggacatggcta																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:6939090A>T	uc001qra.1	+	4	600	c.566A>T	c.(565-567)CAG>CTG	p.Q189L	LEPREL2_uc001qqz.1_5'UTR|LEPREL2_uc001qrb.1_5'UTR|GPR162_uc001qqy.1_Missense_Mutation_p.Q124L	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	189					negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ATGCACCTGCAGATGCGGGAG	0.602													25	91					0	0	0	0	T	6939090	T	T	6939090	3	4	154	1	0	0	0	0	1	0	0	0	8771	188	7	5	571	5	LEPREL2	12	6939090	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	2	6939090	126912805	486	28333	56	2									
ATN1	1822	broad.mit.edu	37	chr12	7047658	7047658	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacagaagttggctcaggaGggccgtgctccggtggaatg	8	7	16	10	2	1	1	1	0	0	1	2	3	2	3	3	5	1	3	3	5	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:7047658G>C	uc001qrw.1	+	7	2769	c.2532G>C	c.(2530-2532)GAG>GAC	p.E844D	ATN1_uc001qrx.1_Missense_Mutation_p.E844D	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	844					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TGGCTCAGGAGGGCCGTGCTC	0.587											OREG0021641	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	31					0	0	0	0	C	7047658	C	C	7047658	3	2	154	1	0	0	0	0	1	0	0	0	1113	991	35	4	2554	4	ATN1	12	7047658	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	108568	7047658	126804237	487	28334											
C1S	716	broad.mit.edu	37	chr12	7177304	7177304	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatgagtactgggtgctgacGgctgctcatgttgtggaggg	7	11	17	6	1	1	2	1	2	0	0	1	3	1	3	0	4	3	5	0	4	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:7177304G>T	uc001qsj.2	+	15	2135	c.1416G>T	c.(1414-1416)ACG>ACT	p.T472T	C1S_uc001qsk.2_Silent_p.T472T|C1S_uc001qsl.2_Silent_p.T472T|C1S_uc009zfr.2_Silent_p.T305T|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	472	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GGGTGCTGACGGCTGCTCATG	0.517													8	35					0.000157383	0.000305386	1	0	T	7177304	T	T	7177304	2	4	154	1	0	0	0	0	0	0	0	1	1983	1103	39	3		3	C1S	12	7177304	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	129646	7177304	126674591	488	28335											
C3AR1	719	broad.mit.edu	37	chr12	8211440	8211440	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaattccctgaatggactGccttgctttcttcctaaaat	10	14	6	11	0	1	2	0	1	1	1	3	3	3	3	3	1	2	1	3	1	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:8211440G>A	uc001qtv.1	-	2	1434	c.1342C>T	c.(1342-1344)CAG>TAG	p.Q448*		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	448	Cytoplasmic (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		TGAATGGACTGCCTTGCTTTC	0.458													17	80					0	0	0	0	A	8211440	A	A	8211440	4	1	154	1	0	0	0	0	0	1	0	0	2215	1328	46	4	110	4	C3AR1	12	8211440	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1034136	8211440	125640455	489	28336											
C12orf69	440087	broad.mit.edu	37	chr12	14959575	14959575	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgatttacttcttcccgccTttttgggttctctgggtaaa	6	17	8	10	2	2	0	0	0	2	0	4	1	3	0	2	2	1	2	2	2	3	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:14959575T>G	uc001rck.1	-	2	113	c.40A>C	c.(40-42)AGG>CGG	p.R14R	C12orf60_uc001rcj.3_Intron	NM_001013698	NP_001013720	A2RU48	CL069_HUMAN	hypothetical protein LOC440087	14						integral to membrane					0						TCTTCCCGCCTTTTTGGGTTC	0.378													4	139					0	0	0	0	G	14959575	G	G	14959575	2	3	154	1	0	0	0	0	0	0	0	1	1717	1608	56	5		5	C12orf69	12	14959575	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	6748135	14959575	118892320	490	28337											
ABCC9	10060	broad.mit.edu	37	chr12	21970162	21970162	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgactccatagtcaggaaaCtgttcaccttcttcactgca	10	12	6	13	0	4	1	3	1	1	0	5	2	5	2	2	1	2	2	2	1	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:21970162C>A	uc001rfi.1	-	31	3871	c.3851G>T	c.(3850-3852)AGT>ATT	p.S1284I	ABCC9_uc001rfh.2_Missense_Mutation_p.S1284I|ABCC9_uc001rfj.1_Missense_Mutation_p.S1248I	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1284	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGTCAGGAAACTGTTCACCTT	0.368													16	108					5.3912e-06	1.09316e-05	1	0	A	21970162	A	A	21970162	3	1	154	1	0	0	0	0	1	0	0	0	59	565	20	4	972	4	ABCC9	12	21970162	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	7010587	21970162	111881733	491	28338											
ABCC9	10060	broad.mit.edu	37	chr12	21970227	21970227	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagttcctcacaacccaattCaaataattggttatctgtgt	13	14	5	9	0	3	0	2	0	1	0	4	0	4	0	2	1	1	2	2	1	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:21970227C>A	uc001rfi.1	-	31	3806	c.3786G>T	c.(3784-3786)TTG>TTT	p.L1262F	ABCC9_uc001rfh.2_Missense_Mutation_p.L1262F|ABCC9_uc001rfj.1_Missense_Mutation_p.L1226F	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1262	Helical; Name=15; (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAACCCAATTCAAATAATTGG	0.378													11	65					3.86212e-05	7.65457e-05	1	0	A	21970227	A	A	21970227	3	1	154	1	0	0	0	0	1	0	0	0	59	825	29	2	1037	2	ABCC9	12	21970227	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	65	21970227	111881668	492	28339											
PPFIBP1	8496	broad.mit.edu	37	chr12	27788028	27788028	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacagcagaaacgcttgttGaatggcttcagagtcaaatg	14	9	10	8	1	2	3	2	1	0	2	2	3	2	3	0	1	3	4	0	1	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:27788028G>C	uc001ric.1	+	4	627	c.250G>C	c.(250-252)GAA>CAA	p.E84Q	PPFIBP1_uc001rhy.1_Missense_Mutation_p.E84Q|PPFIBP1_uc001rhz.1_Missense_Mutation_p.E84Q|PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Missense_Mutation_p.E84Q|PPFIBP1_uc001ria.2_Missense_Mutation_p.E84Q|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	84					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					AACGCTTGTTGAATGGCTTCA	0.408													17	59					0	0	0	0	C	27788028	C	C	27788028	3	2	154	1	0	0	0	0	1	0	0	0	12368	1291	45	2	256	2	PPFIBP1	12	27788028	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5817801	27788028	106063867	493	28340											
BICD1	636	broad.mit.edu	37	chr12	32260340	32260340	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggctaaccaaggagctcacGgagaccacccacgagaagat	15	3	11	12	2	1	3	1	0	0	3	1	6	1	4	3	3	2	2	3	3	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:32260340G>C	uc001rku.2	+	1	156	c.75G>C	c.(73-75)ACG>ACC	p.T25T	BICD1_uc001rkv.2_Silent_p.T25T|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	25	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			AGGAGCTCACGGAGACCACCC	0.572													6	15					0	0	0	0	C	32260340	C	C	32260340	2	2	154	1	0	0	0	0	0	0	0	1	1431	1103	39	3		3	BICD1	12	32260340	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4472312	32260340	101591555	494	28341											
FGD4	121512	broad.mit.edu	37	chr12	32793299	32793299	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccacacagtttcaaactGacccagtctaagtccgtgca	11	9	7	14	1	2	1	1	1	1	0	3	1	3	1	3	0	3	2	3	0	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:32793299G>T	uc001rkz.2	+	17	2610	c.2133G>T	c.(2131-2133)CTG>CTT	p.L711L	FGD4_uc001rlc.2_Silent_p.L796L|FGD4_uc001rla.2_Silent_p.L367L|FGD4_uc010ske.1_Silent_p.L823L|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	711	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					GTTTCAAACTGACCCAGTCTA	0.517													19	95					5.35267e-07	1.1189e-06	1	0	T	32793299	T	T	32793299	2	4	154	1	0	0	0	0	0	0	0	1	5867	1277	45	2		2	FGD4	12	32793299	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	532959	32793299	101058596	495	28342											
LRRK2	120892	broad.mit.edu	37	chr12	40697896	40697896	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaagcatatttatggtctaGagtagagaaactgcatcttt	15	13	8	5	0	2	2	0	0	2	2	2	3	2	2	0	1	3	3	0	1	7	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:40697896G>C	uc001rmg.3	+	27	3858	c.3737G>C	c.(3736-3738)AGA>ACA	p.R1246T	LRRK2_uc001rmh.1_Missense_Mutation_p.R868T|LRRK2_uc009zjw.2_Missense_Mutation_p.R84T|LRRK2_uc001rmi.2_Missense_Mutation_p.R79T	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1246	LRR 11.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTATGGTCTAGAGTAGAGAAA	0.343													4	42					0	0	0	0	C	40697896	C	C	40697896	3	2	154	1	0	0	0	0	1	0	0	0	9083	942	33	2	3843	2	LRRK2	12	40697896	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	7904597	40697896	93153999	496	28343											
CNTN1	1272	broad.mit.edu	37	chr12	41327310	41327310	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtagttcagttcaaggatGtatatgcattgatgggccaa	11	14	11	5	0	2	1	2	1	0	0	2	2	2	2	1	2	1	5	1	2	5	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:41327310G>A	uc001rmm.1	+	8	864	c.751G>A	c.(751-753)GTA>ATA	p.V251I	CNTN1_uc009zjy.1_Missense_Mutation_p.V251I|CNTN1_uc001rmn.1_Missense_Mutation_p.V240I|CNTN1_uc001rmo.2_Missense_Mutation_p.V251I	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	251	Ig-like C2-type 3.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GTTCAAGGATGTATATGCATT	0.299													25	73					0	0	0	0	A	41327310	A	A	41327310	3	1	154	1	0	0	0	0	1	0	0	0	3655	1377	48	4	777	4	CNTN1	12	41327310	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	629414	41327310	92524585	497	28344											
ADAMTS20	80070	broad.mit.edu	37	chr12	43862412	43862412	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaggtacttacgtgtgcccaAgctcatgggctatagtaaaa	13	10	10	8	1	1	0	1	0	0	0	1	0	1	0	1	2	4	4	1	2	8	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:43862412A>G	uc010skx.1	-	8	1214	c.1214T>C	c.(1213-1215)CTT>CCT	p.L405P		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	405	Peptidase M12B.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CGTGTGCCCAAGCTCATGGGC	0.363													15	38					0	0	0	0	G	43862412	G	G	43862412	3	3	154	1	0	0	0	0	1	0	0	0	266	72	3	5	4645	5	ADAMTS20	12	43862412	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	2535102	43862412	89989483	498	28345											
MLL2	8085	broad.mit.edu	37	chr12	49434307	49434307	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggagctggactgggactGaggactggcaggcactcggg	7	6	19	9	1	0	1	0	1	0	0	1	5	0	5	0	7	1	3	0	7	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:49434307G>A	uc001rta.3	-	31	7246	c.7246C>T	c.(7246-7248)CAG>TAG	p.Q2416*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2416	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GACTGGGACTGAGGACTGGCA	0.647			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			5	33					0	0	0	0	A	49434307	A	A	49434307	4	1	154	1	0	0	0	0	0	1	0	0	9674	1299	45	2	9463	2	MLL2	12	49434307	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5571895	49434307	84417588	499	28346											
POU6F1	5463	broad.mit.edu	37	chr12	51584173	51584173	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgtgggcagtgggttctTctcaaaataggcattgagag	9	11	14	7	0	2	1	1	1	2	1	3	2	2	1	1	3	0	3	1	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:51584173T>A	uc001rxy.2	-	5	955	c.763A>T	c.(763-765)AAG>TAG	p.K255*	POU6F1_uc001rxz.2_Nonsense_Mutation_p.K255*|POU6F1_uc001rya.2_Nonsense_Mutation_p.K255*	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	255	Homeobox.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGTGGGTTCTTCTCAAAATAG	0.567													24	115					0	0	0	0	A	51584173	A	A	51584173	4	1	154	1	0	0	0	0	0	1	0	0	12339	1792	62	5	146	5	POU6F1	12	51584173	Nonsense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	2149866	51584173	82267722	500	28347											
SCN8A	6334	broad.mit.edu	37	chr12	52200604	52200604	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccacagaggaaagtgcagaCcctctgagtgaggatgactt	12	7	13	9	0	1	5	0	3	1	2	1	7	1	7	2	2	1	1	2	2	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:52200604C>G	uc001ryw.2	+	27	5512	c.5334C>G	c.(5332-5334)GAC>GAG	p.D1778E		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1778	IV.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AAAGTGCAGACCCTCTGAGTG	0.463													15	134					0	0	0	0	G	52200604	G	G	52200604	3	3	154	1	0	0	0	0	1	0	0	0	13989	506	18	4	5436	4	SCN8A	12	52200604	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	616431	52200604	81651291	501	28348											
KRT4	3851	broad.mit.edu	37	chr12	53202496	53202496	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtacagggcttcagcctCagccttgctcctctgggcaa	6	10	11	14	0	3	0	2	0	1	0	4	0	4	0	3	3	4	4	3	3	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:53202496C>G	uc001saz.2	-	5	1466	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	325						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						GCTTCAGCCTCAGCCTTGCTC	0.572													7	68					0	0	0	0	G	53202496	G	G	53202496	3	3	154	1	0	0	0	0	1	0	0	0	8516	835	29	2	609	2	KRT4	12	53202496	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1001892	53202496	80649399	502	28349											
HOXC11	3227	broad.mit.edu	37	chr12	54367536	54367536	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccgcccgccgagccccccTgctccggcaagggcgaggcc	5	2	13	21	5	0	0	0	0	0	0	1	2	1	0	8	3	2	2	8	3	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:54367536T>G	uc001sem.2	+	1	627	c.511T>G	c.(511-513)TGC>GGC	p.C171G		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	171					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CGAGCCCCCCTGCTCCGGCAA	0.711			T	NUP98	AML								6	38					0	0	0	0	G	54367536	G	G	54367536	3	3	154	1	0	0	0	0	1	0	0	0	7349	1580	55	5	513	5	HOXC11	12	54367536	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1165040	54367536	79484359	503	28350											
ITGA7	3679	broad.mit.edu	37	chr12	56094761	56094761	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcggcagctgtgccctgctGgcagaacccaaattgttcat	8	9	12	12	1	1	1	1	0	0	1	1	1	1	1	2	3	4	5	2	3	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:56094761G>A	uc001shh.2	-	4	812	c.592C>T	c.(592-594)CAG>TAG	p.Q198*	ITGA7_uc001shg.2_Nonsense_Mutation_p.Q198*|ITGA7_uc010sps.1_Nonsense_Mutation_p.Q101*|ITGA7_uc009znx.2_Nonsense_Mutation_p.Q85*	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	198	FG-GAP 3.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						GTGCCCTGCTGGCAGAACCCA	0.592													4	34					0	0	0	0	A	56094761	A	A	56094761	4	1	154	1	0	0	0	0	0	1	0	0	7920	1357	47	4	3045	4	ITGA7	12	56094761	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1727225	56094761	77757134	504	28351											
INHBC	3626	broad.mit.edu	37	chr12	57843393	57843393	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agtcatcctgggtggagctgCccataggccttttgtggcag	6	11	14	10	0	1	0	1	0	0	0	2	1	2	1	3	4	2	2	3	4	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:57843393C>T	uc001snv.1	+	2	774	c.647C>T	c.(646-648)GCC>GTC	p.A216V		NM_005538	NP_005529	P55103	INHBC_HUMAN	inhibin beta C chain preproprotein	216					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding				0						GGTGGAGCTGCCCATAGGCCT	0.622													13	47					0	0	0	0	T	57843393	T	T	57843393	3	4	154	1	0	0	0	0	1	0	0	0	7782	739	26	4	653	4	INHBC	12	57843393	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1748632	57843393	76008502	505	28352											
DCTN2	10540	broad.mit.edu	37	chr12	57929539	57929539	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccagtctcaccaagtccCtttgtccccactctcttgtc	6	12	5	18	0	2	0	1	0	2	0	7	0	4	0	5	0	1	0	5	0	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:57929539C>T	uc001som.1	-	3	327	c.195G>A	c.(193-195)AAG>AAA	p.K65K	DCTN2_uc009zpu.1_Silent_p.K70K|DCTN2_uc009zpv.1_5'UTR|DCTN2_uc009zpw.1_5'UTR|DCTN2_uc001soo.1_RNA|DCTN2_uc001son.1_5'UTR|DCTN2_uc001sop.1_5'UTR|DCTN2_uc001soq.1_RNA|DCTN2_uc009zpx.1_Silent_p.K65K	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	65					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			ovary(1)	1						CACCAAGTCCCTTTGTCCCCA	0.498													4	23					0	0	0	0	T	57929539	T	T	57929539	2	4	154	1	0	0	0	0	0	0	0	1	4324	680	24	4		4	DCTN2	12	57929539	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	86146	57929539	75922356	506	28353											
AVPR1A	552	broad.mit.edu	37	chr12	63543842	63543842	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccacacccgcttgctctgCacccttgctctggcgcgacg	4	8	11	18	4	2	0	0	0	2	0	2	1	2	0	3	2	3	4	3	2	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:63543842C>A	uc001sro.1	-	1	2749	c.775G>T	c.(775-777)GCA>TCA	p.A259S		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	259	Cytoplasmic (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	GCTTGCTCTGCACCCTTGCTC	0.612													23	96					1.96895e-08	4.22639e-08	1	0	A	63543842	A	A	63543842	3	1	154	1	0	0	0	0	1	0	0	0	1233	710	25	4	489	4	AVPR1A	12	63543842	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	5614303	63543842	70308053	507	28354											
CPM	1368	broad.mit.edu	37	chr12	69265656	69265656	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtatccgggtactattgatCagatttgtgatttcagggtc	8	16	11	6	1	2	3	2	2	0	1	4	3	3	3	1	2	1	2	1	2	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:69265656C>G	uc001sup.2	-	4	400	c.339G>C	c.(337-339)CTG>CTC	p.L113L	CPM_uc001sur.2_Silent_p.L113L|CPM_uc001suq.2_Silent_p.L113L	NM_198320	NP_938079	P14384	CBPM_HUMAN	carboxypeptidase M precursor	113					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding				0	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TACTATTGATCAGATTTGTGA	0.443													14	83					0	0	0	0	G	69265656	G	G	69265656	2	3	154	1	0	0	0	0	0	0	0	1	3823	813	29	2		2	CPM	12	69265656	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	5721814	69265656	64586239	508	28355											
BEST3	144453	broad.mit.edu	37	chr12	70049561	70049561	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttctcataatcccacagcCactcctcgtcaggaaagtcg	10	9	7	15	2	2	0	2	0	1	0	7	1	4	1	3	1	1	1	3	1	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:70049561C>T	uc001svg.2	-	10	1360	c.1133G>A	c.(1132-1134)TGG>TAG	p.W378*	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Nonsense_Mutation_p.W165*|BEST3_uc010stm.1_Nonsense_Mutation_p.W272*	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	378	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			ATCCCACAGCCACTCCTCGTC	0.552													30	90					0	0	0	0	T	70049561	T	T	70049561	4	4	154	1	0	0	0	0	0	1	0	0	1408	595	21	4	877	4	BEST3	12	70049561	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	783905	70049561	63802334	509	28356											
PTPRB	5787	broad.mit.edu	37	chr12	70954649	70954649	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccagaggctggactccAgttgaaccaaaggctgtctg	9	8	12	12	0	1	2	0	1	1	1	3	3	3	3	4	3	1	3	4	3	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:70954649A>T	uc001swb.3	-	15	3610	c.3580T>A	c.(3580-3582)TGG>AGG	p.W1194R	PTPRB_uc010sto.1_Missense_Mutation_p.W1104R|PTPRB_uc010stp.1_Missense_Mutation_p.W1104R|PTPRB_uc001swc.3_Missense_Mutation_p.W1412R|PTPRB_uc001swa.3_Missense_Mutation_p.W1324R|PTPRB_uc001swd.3_Missense_Mutation_p.W1411R|PTPRB_uc009zrr.1_Missense_Mutation_p.W1291R	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1194	Fibronectin type-III 14.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GCTGGACTCCAGTTGAACCAA	0.458													16	88					0	0	0	0	T	70954649	T	T	70954649	3	4	154	1	0	0	0	0	1	0	0	0	12861	188	7	5	2485	5	PTPRB	12	70954649	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	905088	70954649	62897246	510	28357											
KRR1	11103	broad.mit.edu	37	chr12	75895584	75895584	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtctcttactgatggcttCtgcttgtttagcctacatta	6	19	7	9	0	2	1	0	1	2	0	3	1	2	1	1	1	4	3	1	1	4	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:75895584C>T	uc001sxt.2	-	9	963	c.922G>A	c.(922-924)GAA>AAA	p.E308K	GLIPR1_uc001sxs.2_3'UTR|KRR1_uc009zsc.2_Missense_Mutation_p.E251K	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	308	Lys-rich.				rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						CTGATGGCTTCTGCTTGTTTA	0.284													6	29					0	0	0	0	T	75895584	T	T	75895584	3	4	154	1	0	0	0	0	1	0	0	0	8485	922	32	2	231	2	KRR1	12	75895584	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4940935	75895584	57956311	511	28358											
NAV3	89795	broad.mit.edu	37	chr12	78562546	78562546	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attccacaggaatctgaactTatagaactaagagaaaccat	18	9	6	8	0	1	3	0	1	1	2	2	5	2	4	2	1	3	0	2	1	7	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:78562546T>A	uc001syp.2	+	24	5054	c.4881T>A	c.(4879-4881)CTT>CTA	p.L1627L	NAV3_uc001syo.2_Silent_p.L1627L|NAV3_uc010sub.1_Silent_p.L1113L|NAV3_uc009zsf.2_Silent_p.L458L	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1627	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AATCTGAACTTATAGAACTAA	0.408										HNSCC(70;0.22)			24	93					0	0	0	0	A	78562546	A	A	78562546	2	1	154	1	0	0	0	0	0	0	0	1	10238	1741	61	5		5	NAV3	12	78562546	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	2666962	78562546	55289349	512	28359											
PPFIA2	8499	broad.mit.edu	37	chr12	81768487	81768487	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcagcctttctcatggtctGctgcaacttttgttcagcta	6	17	7	11	0	4	0	3	0	2	0	5	0	4	0	1	1	5	4	1	1	2	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:81768487G>T	uc001szo.1	-	11	1353	c.1192C>A	c.(1192-1194)CAG>AAG	p.Q398K	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	324										ovary(3)|lung(2)|pancreas(1)	6						CTCATGGTCTGCTGCAACTTT	0.458													24	58					2.21704e-12	5.12835e-12	1	0	T	81768487	T	T	81768487	3	4	154	1	0	0	0	0	1	0	0	0	12365	1328	46	4	2669	4	PPFIA2	12	81768487	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3205941	81768487	52083408	513	28360											
MGAT4C	25834	broad.mit.edu	37	chr12	86373115	86373115	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataattagccattccttttgTgttttggtgacatatatcct	9	19	6	7	0	0	1	0	1	0	0	2	1	2	1	3	1	1	1	3	1	4	9			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:86373115T>G	uc001tai.3	-	8	2639	c.1389A>C	c.(1387-1389)ACA>ACC	p.T463T	MGAT4C_uc001tal.3_Silent_p.T463T|MGAT4C_uc001taj.3_Silent_p.T463T|MGAT4C_uc001tak.3_Silent_p.T463T|MGAT4C_uc010sum.1_Silent_p.T487T|MGAT4C_uc001tah.3_Silent_p.T463T	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	463	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						ATTCCTTTTGTGTTTTGGTGA	0.323													6	28					0	0	0	0	G	86373115	G	G	86373115	2	3	154	1	0	0	0	0	0	0	0	1	9600	1683	59	5		5	MGAT4C	12	86373115	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	4604628	86373115	47478780	514	28361											
EEA1	8411	broad.mit.edu	37	chr12	93170693	93170693	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattgtcttcggcccactttCtattcaacgcttgtgtatgt	6	17	7	11	2	3	0	1	0	2	0	4	0	3	0	1	1	1	2	1	1	3	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:93170693C>G	uc001tck.2	-	28	4305	c.4040G>C	c.(4039-4041)AGA>ACA	p.R1347T		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	1347	Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						GGCCCACTTTCTATTCAACGC	0.333													8	109					0	0	0	0	G	93170693	G	G	93170693	3	3	154	1	0	0	0	0	1	0	0	0	4943	913	32	2	203	2	EEA1	12	93170693	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6797578	93170693	40681202	515	28362											
PLXNC1	10154	broad.mit.edu	37	chr12	94694716	94694716	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcttctgggtaaacatcctGaagaaccctcagtttgtctt	9	13	8	11	1	3	2	1	1	2	1	4	2	4	2	2	1	2	3	2	1	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:94694716G>A	uc001tdc.2	+	28	4518	c.4269G>A	c.(4267-4269)CTG>CTA	p.L1423L	PLXNC1_uc010sut.1_Silent_p.L470L|PLXNC1_uc009zsv.2_Silent_p.L162L	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	1423	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						TAAACATCCTGAAGAACCCTC	0.423													14	52					0	0	0	0	A	94694716	A	A	94694716	2	1	154	1	0	0	0	0	0	0	0	1	12181	1277	45	2		2	PLXNC1	12	94694716	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1524023	94694716	39157179	516	28363											
IKBIP	121457	broad.mit.edu	37	chr12	99007959	99007959	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtctacttttgtaatgtCttgagaaagcgtcgtcagac	9	15	10	7	2	3	2	1	1	2	2	4	3	3	2	0	1	2	1	0	1	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:99007959C>G	uc001tfv.2	-	3	567	c.457G>C	c.(457-459)GAC>CAC	p.D153H	IKBIP_uc001tfw.2_3'UTR	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	153					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0						TTTGTAATGTCTTGAGAAAGC	0.363													18	55					0	0	0	0	G	99007959	G	G	99007959	3	3	154	1	0	0	0	0	1	0	0	0	7648	913	32	2	599	2	IKBIP	12	99007959	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4313243	99007959	34843936	517	28364											
GAS2L3	283431	broad.mit.edu	37	chr12	101017491	101017491	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaggagtttctaatgaaaGtgtacctgattcgcctgcca	13	11	9	8	1	1	2	0	2	1	0	2	3	1	3	3	1	2	2	3	1	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:101017491G>T	uc001thu.2	+	10	1134	c.908G>T	c.(907-909)AGT>ATT	p.S303I	GAS2L3_uc009zty.2_Missense_Mutation_p.S303I|GAS2L3_uc001thv.2_Missense_Mutation_p.S199I	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	303					cell cycle arrest					skin(1)	1						TCTAATGAAAGTGTACCTGAT	0.378													7	45					2.0095e-06	4.12217e-06	1	0	T	101017491	T	T	101017491	3	4	154	1	0	0	0	0	1	0	0	0	6283	1029	36	4	938	4	GAS2L3	12	101017491	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2009532	101017491	32834404	518	28365											
GAS2L3	283431	broad.mit.edu	37	chr12	101017768	101017768	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaggcataacgaagaaaccGcaggctccttcaaacaatgc	17	5	8	11	2	1	1	1	0	0	1	2	2	2	1	2	2	4	3	2	2	6	2	rs61748062	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:101017768G>C	uc001thu.2	+	10	1411	c.1185G>C	c.(1183-1185)CCG>CCC	p.P395P	GAS2L3_uc009zty.2_Silent_p.P395P|GAS2L3_uc001thv.2_Silent_p.P291P	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	395					cell cycle arrest					skin(1)	1						CGAAGAAACCGCAGGCTCCTT	0.418													28	87					0	0	0	0	C	101017768	C	C	101017768	2	2	154	1	0	0	0	0	0	0	0	1	6283	1074	38	3		3	GAS2L3	12	101017768	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	277	101017768	32834127	519	28366											
C12orf42	374470	broad.mit.edu	37	chr12	103699898	103699898	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttccaaaaatgaactgttcCaagcctgcttgggtgctcct	9	12	9	11	0	0	1	0	1	0	0	3	1	3	1	4	1	4	4	4	1	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:103699898C>T	uc001tjt.2	-	5	573	c.485G>A	c.(484-486)TGG>TAG	p.W162*	C12orf42_uc001tjs.2_Intron|C12orf42_uc009zuf.1_Nonsense_Mutation_p.W162*|C12orf42_uc001tju.2_Nonsense_Mutation_p.W67*	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	162										ovary(1)|central_nervous_system(1)	2						TGAACTGTTCCAAGCCTGCTT	0.493													13	48					0	0	0	0	T	103699898	T	T	103699898	4	4	154	1	0	0	0	0	0	1	0	0	1694	595	21	4	605	4	C12orf42	12	103699898	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2682130	103699898	30151997	520	28367											
STAB2	55576	broad.mit.edu	37	chr12	103988252	103988252	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaaggactatctccaacctCggtgttgtcctggccgctgg	6	10	13	12	2	1	0	0	0	1	0	4	2	2	2	4	5	1	2	4	5	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:103988252C>T	uc001tjw.2	+	3	481	c.295C>T	c.(295-297)CGG>TGG	p.R99W		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	99	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TCTCCAACCTCGGTGTTGTCC	0.493													21	100					0	0	0	0	T	103988252	T	T	103988252	3	4	154	1	0	0	0	0	1	0	0	0	15304	875	31	1	305	1	STAB2	12	103988252	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	288354	103988252	29863643	521	28368											
HSP90B1	7184	broad.mit.edu	37	chr12	104335647	104335647	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccttgaatgtttcccgcgAgactcttcagcaacataaac	11	10	6	14	2	2	2	1	1	1	1	3	3	3	2	3	0	3	2	3	0	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:104335647A>T	uc001tkb.1	+	11	1451	c.1346A>T	c.(1345-1347)GAG>GTG	p.E449V	HSP90B1_uc010swg.1_Missense_Mutation_p.E114V|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	449					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	GTTTCCCGCGAGACTCTTCAG	0.453													18	58					0	0	0	0	T	104335647	T	T	104335647	3	4	154	1	0	0	0	0	1	0	0	0	7442	304	11	5	1388	5	HSP90B1	12	104335647	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	347395	104335647	29516248	522	28369											
CHST11	50515	broad.mit.edu	37	chr12	105151344	105151344	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccctgccacatccactatgaCctcgtgggcaagtacgagac	10	7	9	15	2	0	2	0	1	0	1	2	3	1	2	4	1	2	2	4	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:105151344C>G	uc001tkx.1	+	4	1113	c.822C>G	c.(820-822)GAC>GAG	p.D274E	CHST11_uc001tky.2_Missense_Mutation_p.D269E|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	274	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						TCCACTATGACCTCGTGGGCA	0.547													3	29					0	0	0	0	G	105151344	G	G	105151344	3	3	154	1	0	0	0	0	1	0	0	0	3414	506	18	4	832	4	CHST11	12	105151344	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	815697	105151344	28700551	523	28370											
ALDH2	217	broad.mit.edu	37	chr12	112229161	112229161	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgcctggatttggccccacgGctggggccgccattgcctcc	3	9	13	16	2	0	0	0	0	0	0	1	1	1	1	7	5	2	1	7	5	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:112229161G>T	uc001tst.2	+	7	1174	c.733G>T	c.(733-735)GCT>TCT	p.A245S	ALDH2_uc010syi.1_Missense_Mutation_p.A198S|ALDH2_uc009zvy.2_Intron	NM_000690	NP_000681	P05091	ALDH2_HUMAN	mitochondrial aldehyde dehydrogenase 2	245					carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase|electron carrier activity			skin(2)|ovary(1)|central_nervous_system(1)	4					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)	TGGCCCCACGGCTGGGGCCGC	0.587			T	HMGA2	leiomyoma								5	18					0.00307968	0.00575353	1	0	T	112229161	T	T	112229161	3	4	154	1	0	0	0	0	1	0	0	0	496	1203	42	4	759	4	ALDH2	12	112229161	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	7077817	112229161	21622734	524	28371											
RPL6	6128	broad.mit.edu	37	chr12	112846080	112846080	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accacccgggtaccgccgttCttgtcaccaccaactggttt	7	10	8	16	3	2	0	1	0	1	0	2	0	2	0	6	2	2	3	6	2	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:112846080C>G	uc001ttu.2	-	3	529	c.300G>C	c.(298-300)AAG>AAC	p.K100N	RPL6_uc001ttv.2_Missense_Mutation_p.K100N|RPL6_uc009zwd.1_3'UTR	NM_001024662	NP_001019833	Q02878	RL6_HUMAN	ribosomal protein L6	100			K -> Q (in a colorectal cancer sample; somatic mutation).		endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome	p.K100Q(1)		large_intestine(1)	1						TACCGCCGTTCTTGTCACCAC	0.413													10	74					0	0	0	0	G	112846080	G	G	112846080	3	3	154	1	0	0	0	0	1	0	0	0	13663	912	32	2	586	2	RPL6	12	112846080	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	616919	112846080	21005815	525	28372											
DDX54	79039	broad.mit.edu	37	chr12	113614713	113614713	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcatttccacagccacatgCaccaaccgtccgggcgtggc	8	7	9	17	3	1	0	1	0	0	0	3	0	3	0	5	2	3	1	5	2	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:113614713C>A	uc001tup.2	-	7	712	c.684G>T	c.(682-684)GTG>GTT	p.V228V	DDX54_uc001tuq.3_Silent_p.V228V	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	228	Helicase ATP-binding.				estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						CAGCCACATGCACCAACCGTC	0.592													16	55					3.41278e-10	7.63317e-10	1	0	A	113614713	A	A	113614713	2	1	154	1	0	0	0	0	0	0	0	1	4389	697	25	4		4	DDX54	12	113614713	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	768633	113614713	20237182	526	28373											
RBM19	9904	broad.mit.edu	37	chr12	114261089	114261089	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttccagctgctccaggatCtcgtccaacaccacagaccg	9	7	7	18	2	1	1	0	0	1	1	5	2	4	2	6	1	3	2	6	1	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:114261089C>G	uc009zwi.2	-	24	2967	c.2823G>C	c.(2821-2823)GAG>GAC	p.E941D	RBM19_uc001tvn.3_Missense_Mutation_p.E941D|RBM19_uc001tvm.2_Missense_Mutation_p.E941D	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	941					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GCTCCAGGATCTCGTCCAACA	0.607													3	29					0	0	0	0	G	114261089	G	G	114261089	3	3	154	1	0	0	0	0	1	0	0	0	13186	912	32	2	63	2	RBM19	12	114261089	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	646376	114261089	19590806	527	28374											
TBX5	6910	broad.mit.edu	37	chr12	114839711	114839711	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttcatggagaaacactttGattccctccatgccctgcaa	10	12	6	13	0	1	2	1	1	0	1	3	3	3	2	3	1	3	1	3	1	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:114839711G>C	uc001tvo.2	-	3	657	c.162C>G	c.(160-162)ATC>ATG	p.I54M	TBX5_uc001tvp.2_Missense_Mutation_p.I54M|TBX5_uc001tvq.2_Missense_Mutation_p.I4M|TBX5_uc010syv.1_Missense_Mutation_p.I54M	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	54			I -> T (in HOS).		cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GAAACACTTTGATTCCCTCCA	0.473													6	41					0	0	0	0	C	114839711	C	C	114839711	3	2	154	1	0	0	0	0	1	0	0	0	15727	1280	45	2	1489	2	TBX5	12	114839711	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	578622	114839711	19012184	528	28375											
CIT	11113	broad.mit.edu	37	chr12	120135524	120135524	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actccttcacgaggtttcccTtgcagcaaatgacccttaat	10	12	6	13	1	1	1	1	1	0	0	3	2	3	1	3	1	2	3	3	1	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:120135524T>A	uc001txi.1	-	45	5749	c.5696A>T	c.(5695-5697)AAG>ATG	p.K1899M	CIT_uc001txh.1_Missense_Mutation_p.K1418M|CIT_uc001txj.1_Missense_Mutation_p.K1941M	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1899					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GAGGTTTCCCTTGCAGCAAAT	0.582													24	84					0	0	0	0	A	120135524	A	A	120135524	3	1	154	1	0	0	0	0	1	0	0	0	3453	1609	56	5	399	5	CIT	12	120135524	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	5295813	120135524	13716371	529	28376											
ATP6V0A2	23545	broad.mit.edu	37	chr12	124221632	124221632	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaaaaccgaggactatttGaggcaagtgctatgtaaagc	15	8	10	8	1	0	1	0	1	0	0	0	3	0	2	1	2	3	3	1	2	7	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:124221632G>A	uc001ufr.2	+	9	1100	c.852G>A	c.(850-852)TTG>TTA	p.L284L	ATP6V0A2_uc001ufq.1_Silent_p.L284L	NM_012463	NP_036595	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	284	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		AGGACTATTTGAGGCAAGTGC	0.507													11	109					0	0	0	0	A	124221632	A	A	124221632	2	1	154	1	0	0	0	0	0	0	0	1	1171	1281	45	2		2	ATP6V0A2	12	124221632	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4086108	124221632	9630263	530	28377											
SLC15A4	121260	broad.mit.edu	37	chr12	129283841	129283841	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcatccatccgatggctttGatagacaccagtgccagcag	10	9	9	13	1	1	2	1	1	0	1	3	3	3	2	4	1	2	2	4	1	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:129283841G>C	uc001uhu.2	-	7	1589	c.1536C>G	c.(1534-1536)ATC>ATG	p.I512M	SLC15A4_uc001uhv.2_RNA	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	solute carrier family 15, member 4	512					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		CGATGGCTTTGATAGACACCA	0.547													16	57					0	0	0	0	C	129283841	C	C	129283841	3	2	154	1	0	0	0	0	1	0	0	0	14466	1280	45	2	205	2	SLC15A4	12	129283841	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5062209	129283841	4568054	531	28378											
TMEM132D	121256	broad.mit.edu	37	chr12	129558977	129558977	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atacatcccaatttctaagtCgctcagccctttggatgcct	9	13	6	13	1	2	0	1	0	1	0	4	1	3	1	3	1	3	1	3	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:129558977C>G	uc009zyl.1	-	9	3071	c.2743G>C	c.(2743-2745)GAC>CAC	p.D915H	TMEM132D_uc001uia.2_Missense_Mutation_p.D453H	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	915	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ATTTCTAAGTCGCTCAGCCCT	0.488													10	52					0	0	0	0	G	129558977	G	G	129558977	3	3	154	1	0	0	0	0	1	0	0	0	16113	884	31	3	560	3	TMEM132D	12	129558977	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	275136	129558977	4292918	532	28379											
RIMBP2	23504	broad.mit.edu	37	chr12	130912810	130912810	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atacagctcctcctcgtcctCctccatgatgtctgagaggt	7	12	8	14	1	1	2	0	2	1	1	7	3	6	2	5	1	2	1	5	1	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:130912810C>A	uc001uil.2	-	12	2439	c.2275G>T	c.(2275-2277)GAG>TAG	p.E759*		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	759						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCCTCGTCCTCCTCCATGATG	0.612													11	57					9.70103e-10	2.15062e-09	1	0	A	130912810	A	A	130912810	4	1	154	1	0	0	0	0	0	1	0	0	13428	864	30	2	915	2	RIMBP2	12	130912810	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1353833	130912810	2939085	533	28380											
ANKLE2	23141	broad.mit.edu	37	chr12	133327233	133327233	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggctgcatgatttacctttCaacctgtcattgctaaagag	10	13	8	10	1	2	2	2	1	0	1	2	2	2	2	2	1	4	3	2	1	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr12:133327233C>T	uc001ukx.2	-	3	910	c.843G>A	c.(841-843)TTG>TTA	p.L281L	ANKLE2_uc001uky.3_Silent_p.L219L	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	281						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		ATTTACCTTTCAACCTGTCAT	0.423													6	39					0	0	0	0	T	133327233	T	T	133327233	2	4	154	1	0	0	0	0	0	0	0	1	633	825	29	2		2	ANKLE2	12	133327233	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2414423	133327233	524662	534	28381											
PABPC3	5042	broad.mit.edu	37	chr13	25671507	25671507	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagaatggcaagtgtacgaGctgtgcccaaccagcgagca	13	5	13	10	2	0	1	0	0	0	1	0	4	0	1	2	1	6	4	2	1	4	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:25671507G>A	uc001upy.2	+	1	1232	c.1171G>A	c.(1171-1173)GCT>ACT	p.A391T		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	391					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAGTGTACGAGCTGTGCCCAA	0.507													21	99					0	0	0	0	A	25671507	A	A	25671507	3	1	154	1	0	0	0	0	1	0	0	0	11419	971	34	4	1173	4	PABPC3	13	25671507	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08		25671507	89498371	535	28382											
ATP8A2	51761	broad.mit.edu	37	chr13	26402328	26402328	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcatcggcctgtacaatGtggtaagcattcttcatctc	8	13	10	10	1	3	0	1	0	2	0	5	0	3	0	1	3	3	4	1	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:26402328G>T	uc001uqk.2	+	28	2894	c.2752G>T	c.(2752-2754)GTG>TTG	p.V918L	ATP8A2_uc010tdi.1_Intron|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.V468L	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	878	Helical; (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CCTGTACAATGTGGTAAGCAT	0.398													26	127					1.33986e-20	3.28061e-20	1	0	T	26402328	T	T	26402328	3	4	154	1	0	0	0	0	1	0	0	0	1195	1377	48	4	2862	4	ATP8A2	13	26402328	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	730821	26402328	88767550	536	28383											
FLT3	2322	broad.mit.edu	37	chr13	28624246	28624246	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttacctattgtgaacagcCtggtgcattccctgcccagt	7	13	9	12	0	0	1	0	1	0	0	1	1	1	1	4	1	5	2	4	1	3	4	rs61729144	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:28624246C>A	uc001urw.2	-	6	810	c.728G>T	c.(727-729)AGG>ATG	p.R243M	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.R243M	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	243	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGTGAACAGCCTGGTGCATTC	0.428			Mis|O		AML|ALL								21	101					4.35082e-09	9.50153e-09	1	0	A	28624246	A	A	28624246	3	1	154	1	0	0	0	0	1	0	0	0	5974	681	24	4	2329	4	FLT3	13	28624246	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2221918	28624246	86545632	537	28384											
FRY	10129	broad.mit.edu	37	chr13	32813472	32813472	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agttctgtaaggatatagccGaaaggattgctcaggtatga	13	11	12	5	1	2	1	1	1	1	0	2	4	2	3	1	3	2	4	1	3	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:32813472G>A	uc001utx.2	+	45	6998	c.6502G>A	c.(6502-6504)GAA>AAA	p.E2168K	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GGATATAGCCGAAAGGATTGC	0.463													6	58					0	0	0	0	A	32813472	A	A	32813472	3	1	154	1	0	0	0	0	1	0	0	0	6097	1059	37	1	6680	1	FRY	13	32813472	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4189226	32813472	82356406	538	28385											
PDS5B	23047	broad.mit.edu	37	chr13	33271024	33271024	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaggccatattttcaaaaGtgatggttattacaagtaag	15	13	8	5	0	2	1	2	1	0	0	2	1	2	1	1	2	1	2	1	2	8	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:33271024G>T	uc010abf.2	+	15	1743	c.1585G>T	c.(1585-1587)GTG>TTG	p.V529L	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	529					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		ATTTTCAAAAGTGATGGTTAT	0.259													18	54					2.21704e-12	5.12835e-12	1	0	T	33271024	T	T	33271024	3	4	154	1	0	0	0	0	1	0	0	0	11746	1029	36	4	1639	4	PDS5B	13	33271024	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	457552	33271024	81898854	539	28386											
SOHLH2	54937	broad.mit.edu	37	chr13	36744767	36744767	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggctgaaggtaaatgaatTgaaatgttctgatttgttac	13	15	10	3	0	1	4	0	4	1	0	1	4	1	4	0	2	1	4	0	2	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:36744767T>G	uc001uvj.2	-	10	1247	c.1158A>C	c.(1156-1158)TCA>TCC	p.S386S	SOHLH2_uc010tei.1_Silent_p.S463S	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	386					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		GTAAATGAATTGAAATGTTCT	0.493													7	63					0	0	0	0	G	36744767	G	G	36744767	2	3	154	1	0	0	0	0	0	0	0	1	14988	1799	63	5		5	SOHLH2	13	36744767	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	3473743	36744767	78425111	540	28387											
C13orf36	400120	broad.mit.edu	37	chr13	37269082	37269082	+	Translation_Start_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgctgcctttgagaaacaAgttttgttgtgctgatttaa	9	16	9	7	0	0	2	0	2	0	1	0	3	0	2	2	0	4	4	2	0	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:37269082A>T	uc001uvt.3	+	2	313	c.-133A>T	c.(-135--131)CAAGT>CATGT			NM_203451	NP_982276	A2A2V5	CM036_HUMAN	hypothetical protein LOC400120							integral to membrane				skin(1)	1						TTGAGAAACAAGTTTTGTTGT	0.363													6	11					0	0	0	0	T	37269082	T	T	37269082	1	4	154	1	0	0	0	0	0	0	0	0	1736	87	3	5		5	C13orf36	13	37269082	Translation_Start_Site	SNP	A	TCGA-CR-7388-01A-11D-2012-08	524315	37269082	77900796	541	28388											
FAM48A	55578	broad.mit.edu	37	chr13	37622712	37622712	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acacctcacctctgcacgatCcaaagctagttctaaagctt	12	10	5	14	1	3	0	1	0	2	0	4	1	4	0	3	0	3	4	3	0	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:37622712C>G	uc001uwg.2	-	3	276	c.28G>C	c.(28-30)GAT>CAT	p.D10H	FAM48A_uc010abt.2_Missense_Mutation_p.D10H|FAM48A_uc001uwh.2_Missense_Mutation_p.D10H|FAM48A_uc001uwi.2_Missense_Mutation_p.D10H|FAM48A_uc001uwj.2_Missense_Mutation_p.D10H|FAM48A_uc001uwk.2_Missense_Mutation_p.D10H|FAM48A_uc010tes.1_Intron|FAM48A_uc001uwl.1_Missense_Mutation_p.D10H	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	10					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		TCTGCACGATCCAAAGCTAGT	0.269													7	39					0	0	0	0	G	37622712	G	G	37622712	3	3	154	1	0	0	0	0	1	0	0	0	5604	855	30	2	2410	2	FAM48A	13	37622712	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	353630	37622712	77547166	542	28389											
POSTN	10631	broad.mit.edu	37	chr13	38143521	38143521	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggtgaccttggtgacctCtgagaggatacatgtttata	9	15	11	6	0	1	3	0	3	1	1	1	5	1	4	2	3	1	1	2	3	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:38143521C>T	uc001uwo.3	-	21	2466	c.2348_splice	c.e21-1	p.E783_splice	POSTN_uc010tet.1_Splice_Site_p.E284_splice|POSTN_uc001uwp.3_Splice_Site_p.E726_splice|POSTN_uc001uwr.2_Intron|POSTN_uc001uwq.2_Intron|POSTN_uc010teu.1_Splice_Site_p.E756_splice|POSTN_uc010tev.1_Splice_Site_p.E696_splice|POSTN_uc010tew.1_Intron	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1						cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TTGGTGACCTCTGAGAGGATA	0.348													9	48					0	0	0	0	T	38143521	T	T	38143521	5	4	154	1	0	0	0	0	0	0	1	0	12314	927	32	2	175	2	POSTN	13	38143521	Splice_Site	SNP	C	TCGA-CR-7388-01A-11D-2012-08	520809	38143521	77026357	543	28390											
ZC3H13	23091	broad.mit.edu	37	chr13	46542018	46542018	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgcctcgtatctctcctCtctctctcgcgctctctgtc	1	16	5	19	3	5	0	0	0	5	0	13	0	6	0	2	0	1	2	2	0	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:46542018C>T	uc010tfw.1	-	14	3948	c.3942G>A	c.(3940-3942)GAG>GAA	p.E1314E	ZC3H13_uc001vaq.2_5'UTR|ZC3H13_uc001vas.1_Silent_p.E1314E	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1314	Potential.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		tatctctcctctctctctcgc	0.179													12	66					0	0	0	0	T	46542018	T	T	46542018	2	4	154	1	0	0	0	0	0	0	0	1	17632	912	32	2		2	ZC3H13	13	46542018	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	8398497	46542018	68627860	544	28391											
PCDH9	5101	broad.mit.edu	37	chr13	67801710	67801710	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggcaccaaaaatgtacCggatttcagcattactgcct	11	10	8	12	1	1	0	1	0	0	0	1	1	1	1	4	2	4	3	4	2	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:67801710C>T	uc001vik.2	-	2	1555	c.863G>A	c.(862-864)CGG>CAG	p.R288Q	PCDH9_uc001vil.2_Missense_Mutation_p.R288Q|PCDH9_uc010thl.1_Missense_Mutation_p.R288Q|PCDH9_uc001vin.3_Missense_Mutation_p.R288Q	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	288	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		AAAAATGTACCGGATTTCAGC	0.463													17	95					0	0	0	0	T	67801710	T	T	67801710	3	4	154	1	0	0	0	0	1	0	0	0	11572	652	23	1	2866	1	PCDH9	13	67801710	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	21259692	67801710	47368168	545	28392											
KLHL1	57626	broad.mit.edu	37	chr13	70456497	70456497	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcatgtcatacttgaccCacatcatcaatgcatggaag	12	11	7	11	0	4	1	3	1	1	0	4	2	4	2	1	1	3	2	1	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:70456497C>A	uc001vip.2	-	5	1939	c.1145G>T	c.(1144-1146)TGG>TTG	p.W382L	KLHL1_uc010thm.1_Missense_Mutation_p.W321L	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	382					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		ATACTTGACCCACATCATCAA	0.453													10	45					0.000442599	0.000850371	1	0	A	70456497	A	A	70456497	3	1	154	1	0	0	0	0	1	0	0	0	8404	595	21	4	1129	4	KLHL1	13	70456497	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2654787	70456497	44713381	546	28393											
TBC1D4	9882	broad.mit.edu	37	chr13	75930347	75930348	+	Frame_Shift_Ins	INS	-	C	C																															aagtccaggctctggagactINScccggcagataaagccaaag																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:75930347_75930348insC	uc001vjl.1	-	4	1557_1558	c.1210_1211insG	c.(1210-1212)GAGfs	p.E404fs	TBC1D4_uc010aer.2_Frame_Shift_Ins_p.E404fs|TBC1D4_uc010aes.2_Frame_Shift_Ins_p.E404fs	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	404	PID 2.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		CTCTGGAGACTCCCGGCAGATA	0.431													---	---	---								C	75930348	C	C	75930347	7	5	154	1	0	1	1	0	0	0	0	0	15688	1551	54	0	2757	0	TBC1D4	13	75930347	Frame_Shift_Ins	INS	-	TCGA-CR-7388-01A-11D-2012-08	5473850	75930347	39239531	547	28394											
SLITRK6	84189	broad.mit.edu	37	chr13	86369101	86369101	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtcccaggggttatcctCaaggtcaatctgggttagca	9	10	12	10	0	3	0	2	0	1	0	5	0	5	0	2	4	1	4	2	4	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:86369101C>A	uc001vll.1	-	2	2002	c.1543G>T	c.(1543-1545)GAG>TAG	p.E515*	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	515	Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GGGTTATCCTCAAGGTCAATC	0.423													10	81					0.000673444	0.00128547	1	0	A	86369101	A	A	86369101	4	1	154	1	0	0	0	0	0	1	0	0	14811	835	29	2	986	2	SLITRK6	13	86369101	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	10438754	86369101	28800777	548	28395											
SLITRK5	26050	broad.mit.edu	37	chr13	88329558	88329558	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgaggaccagcgccgtgactCctgcggtccggttgaatagc	7	7	14	13	5	0	2	0	2	0	0	2	4	2	3	4	3	3	1	4	3	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:88329558C>A	uc001vln.2	+	2	2134	c.1915C>A	c.(1915-1917)CCT>ACT	p.P639T	SLITRK5_uc010tic.1_Missense_Mutation_p.P398T	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	639	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CGCCGTGACTCCTGCGGTCCG	0.622													12	66					7.03913e-09	1.52024e-08	1	0	A	88329558	A	A	88329558	3	1	154	1	0	0	0	0	1	0	0	0	14810	855	30	2	1917	2	SLITRK5	13	88329558	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1960457	88329558	26840320	549	28396											
NALCN	259232	broad.mit.edu	37	chr13	101944439	101944439	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcaatgataacagcaataaAcacgttctgaaaaaaatcac	20	9	4	8	1	3	2	2	2	1	0	3	2	3	2	0	0	3	2	0	0	8	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:101944439A>G	uc001vox.1	-	9	1138	c.949T>C	c.(949-951)TTT>CTT	p.F317L	NALCN_uc001voy.2_Missense_Mutation_p.F32L|NALCN_uc001voz.2_Missense_Mutation_p.F317L|NALCN_uc001vpa.2_Missense_Mutation_p.F317L	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	317	Helical; Name=S6 of repeat I; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACAGCAATAAACACGTTCTGA	0.403													5	14					0	0	0	0	G	101944439	G	G	101944439	3	3	154	1	0	0	0	0	1	0	0	0	10201	43	2	5	4411	5	NALCN	13	101944439	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	13614881	101944439	13225439	550	28397											
TPP2	7174	broad.mit.edu	37	chr13	103282533	103282533	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatcaatatacttggtcttCtagaggacctaggtaggtgc	12	12	10	7	0	3	1	1	0	2	1	3	2	3	2	1	4	2	1	1	4	7	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:103282533C>G	uc001vpi.3	+	10	1335	c.1232C>G	c.(1231-1233)TCT>TGT	p.S411C		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	411					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACTTGGTCTTCTAGAGGACCT	0.413													14	41					0	0	0	0	G	103282533	G	G	103282533	3	3	154	1	0	0	0	0	1	0	0	0	16479	913	32	2	1270	2	TPP2	13	103282533	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1338094	103282533	11887345	551	28398											
KDELC1	79070	broad.mit.edu	37	chr13	103443611	103443611	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgacttatctctcaccggCccatggtttccagaacagaa	10	10	7	14	1	2	3	1	1	1	2	4	3	3	3	4	2	1	1	4	2	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:103443611C>A	uc001vpq.3	-	5	1226	c.842G>T	c.(841-843)GGC>GTC	p.G281V	KDELC1_uc001vpr.3_Missense_Mutation_p.G62V	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	281						endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CTCTCACCGGCCCATGGTTTC	0.453													60	259					1.83847e-13	4.30937e-13	1	0	A	103443611	A	A	103443611	3	1	154	1	0	0	0	0	1	0	0	0	8156	739	26	4	690	4	KDELC1	13	103443611	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	161078	103443611	11726267	552	28399											
TUBGCP3	10426	broad.mit.edu	37	chr13	113208415	113208415	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccaggctcctctggtccgTgtatcttctgattttattat	5	18	8	10	1	3	1	0	1	3	0	6	1	6	1	3	2	0	2	3	2	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr13:113208415T>C	uc001vse.1	-	8	1109	c.922A>G	c.(922-924)ACG>GCG	p.T308A	TUBGCP3_uc010tjq.1_Missense_Mutation_p.T298A|TUBGCP3_uc001vsf.2_Missense_Mutation_p.T308A|TUBGCP3_uc001vsg.1_Missense_Mutation_p.T308A	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	308					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CTCTGGTCCGTGTATCTTCTG	0.483													39	57					0	0	0	0	C	113208415	C	C	113208415	3	2	154	1	0	0	0	0	1	0	0	0	16835	1696	59	5	1861	5	TUBGCP3	13	113208415	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	9764804	113208415	1961463	553	28400											
TOX4	9878	broad.mit.edu	37	chr14	21960898	21960898	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgattattaccaaacaaatgTtgccctcttctattactatg	12	16	4	9	0	2	1	0	1	2	0	2	1	2	1	2	0	4	1	2	0	7	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:21960898T>G	uc001waz.2	+	7	1226	c.1123T>G	c.(1123-1125)TTG>GTG	p.L375V	TOX4_uc001way.2_Missense_Mutation_p.L245V|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Missense_Mutation_p.L352V|TOX4_uc010tlv.1_Missense_Mutation_p.L245V	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	375						chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		CAAACAAATGTTGCCCTCTTC	0.493													6	124					0	0	0	0	G	21960898	G	G	21960898	3	3	154	1	0	0	0	0	1	0	0	0	16447	1722	60	5	1149	5	TOX4	14	21960898	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08		21960898	85388642	554	28401											
AP1G2	8906	broad.mit.edu	37	chr14	24034829	24034829	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccccacctgcaggaaggggtCgctgactccagatatgctgt	8	8	12	13	1	0	2	0	1	0	1	2	3	1	3	4	3	2	3	4	3	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:24034829C>T	uc001wkl.2	-	7	1064	c.727G>A	c.(727-729)GAC>AAC	p.D243N	AP1G2_uc001wkj.2_5'UTR|AP1G2_uc001wkk.3_Missense_Mutation_p.D171N|AP1G2_uc001wkn.2_5'UTR|uc001wko.1_RNA|AP1G2_uc001wkp.1_5'Flank|AP1G2_uc010tnp.1_Missense_Mutation_p.D243N|AP1G2_uc010aks.2_Missense_Mutation_p.D171N|AP1G2_uc010akt.2_Missense_Mutation_p.D171N|AP1G2_uc010tnq.1_RNA	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	243					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		AGGAAGGGGTCGCTGACTCCA	0.557													9	22					0	0	0	0	T	24034829	T	T	24034829	3	4	154	1	0	0	0	0	1	0	0	0	733	884	31	1	1694	1	AP1G2	14	24034829	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2073931	24034829	83314711	555	28402											
TM9SF1	10548	broad.mit.edu	37	chr14	24659669	24659669	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaatctcccgggcgatgttCttggtgcgacagggtgcatc	6	10	15	10	3	2	0	0	0	2	0	4	3	2	1	1	4	2	2	1	4	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:24659669C>G	uc001wnb.1	-	5	1692	c.1344G>C	c.(1342-1344)AAG>AAC	p.K448N	IPO4_uc001wmu.2_5'Flank|IPO4_uc001wmv.1_5'Flank|IPO4_uc001wmx.1_5'Flank|IPO4_uc001wmy.1_5'Flank|IPO4_uc010tnz.1_5'Flank|IPO4_uc001wmw.1_5'Flank|IPO4_uc001wmz.1_5'UTR|TM9SF1_uc010toa.1_Missense_Mutation_p.K361N|TM9SF1_uc001wna.1_RNA|TM9SF1_uc010tob.1_Missense_Mutation_p.K683N|TM9SF1_uc001wnc.2_Missense_Mutation_p.K448N	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	448					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		GGGCGATGTTCTTGGTGCGAC	0.547													19	58					0	0	0	0	G	24659669	G	G	24659669	3	3	154	1	0	0	0	0	1	0	0	0	16043	912	32	2	527	2	TM9SF1	14	24659669	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	624840	24659669	82689871	556	28403											
PRKD1	5587	broad.mit.edu	37	chr14	30066890	30066890	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctcaggagccaggtaagcGggggtacccaccactgacct	10	5	12	14	1	1	1	1	1	0	0	1	2	1	2	5	4	3	2	5	4	2	2	rs147092748		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:30066890G>A	uc001wqh.2	-	16	2422	c.2241C>T	c.(2239-2241)CCC>CCT	p.P747P		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	747	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CCAGGTAAGCGGGGGTACCCA	0.488													22	38					0	0	0	0	A	30066890	A	A	30066890	2	1	154	1	0	0	0	0	0	0	0	1	12580	1103	39	1		1	PRKD1	14	30066890	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5407221	30066890	77282650	557	28404											
NKX2-1	7080	broad.mit.edu	37	chr14	36988380	36988380	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggcggcggtgacggcgccGtggtgccccacggcgtgctg	3	6	19	13	7	0	1	0	1	0	0	0	1	0	1	3	6	2	1	3	6	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:36988380G>A	uc001wtt.2	-	1	524	c.183C>T	c.(181-183)CAC>CAT	p.H61H	SFTA3_uc001wts.2_Intron|NKX2-1_uc001wtu.2_Silent_p.H91H|NKX2-1_uc001wtv.2_Silent_p.H61H|uc001wtw.1_5'Flank	NM_003317	NP_003308	P43699	NKX21_HUMAN	thyroid transcription factor 1 isoform 2	61				H -> P (in Ref. 5; BAA23527/BAA23529).	epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			skin(1)	1	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		TGACGGCGCCGTGGTGCCCCA	0.746			A		NSCLC								11	7					0	0	0	0	A	36988380	A	A	36988380	2	1	154	1	0	0	0	0	0	0	0	1	10503	1136	40	1		1	NKX2-1	14	36988380	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	6921490	36988380	70361160	558	28405											
FANCM	57697	broad.mit.edu	37	chr14	45605509	45605509	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctaccaattgcccagtgcGggactaccagctgcacattt	9	9	8	15	1	0	0	0	0	0	0	0	1	0	1	4	1	6	2	4	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:45605509G>C	uc001wwd.3	+	1	374	c.275G>C	c.(274-276)CGG>CCG	p.R92P	FANCM_uc001wwc.2_Missense_Mutation_p.R92P|FANCM_uc010anf.2_Missense_Mutation_p.R92P|FKBP3_uc010tqf.1_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	92					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TGCCCAGTGCGGGACTACCAG	0.597								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				13	53					0	0	0	0	C	45605509	C	C	45605509	3	2	154	1	0	0	0	0	1	0	0	0	5703	1116	39	3	277	3	FANCM	14	45605509	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	8617129	45605509	61744031	559	28406											
MGAT2	4247	broad.mit.edu	37	chr14	50088061	50088061	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcctgcggcttcgtcctctgGagcagcaatgggcgacaaag	8	7	14	12	3	1	0	0	0	1	0	3	2	2	1	2	3	3	3	2	3	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:50088061G>A	uc001wwr.2	+	1	573	c.75G>A	c.(73-75)TGG>TGA	p.W25*	SDCCAG1_uc010anj.1_Intron|RPL36AL_uc001wwq.1_5'Flank	NM_002408	NP_002399	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein	25	Helical; Signal-anchor for type II membrane protein; (Potential).				oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity				0	all_epithelial(31;0.0021)|Breast(41;0.0124)					TCGTCCTCTGGAGCAGCAATG	0.692													5	25					0	0	0	0	A	50088061	A	A	50088061	4	1	154	1	0	0	0	0	0	1	0	0	9596	1183	41	2	77	2	MGAT2	14	50088061	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4482552	50088061	57261479	560	28407											
PYGL	5836	broad.mit.edu	37	chr14	51375033	51375033	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgacacttgacataggcttCgtagtctgcaaagactttaa	12	13	8	8	1	1	3	0	2	1	1	2	3	1	3	0	1	1	3	0	1	4	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:51375033C>A	uc001wyu.2	-	19	2462	c.2335G>T	c.(2335-2337)GAA>TAA	p.E779*	PYGL_uc010tqq.1_Nonsense_Mutation_p.E745*|PYGL_uc001wyv.2_Nonsense_Mutation_p.E453*|PYGL_uc001wyt.2_RNA	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	779					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	ACATAGGCTTCGTAGTCTGCA	0.303													14	41					2.31682e-05	4.62838e-05	1	0	A	51375033	A	A	51375033	4	1	154	1	0	0	0	0	0	1	0	0	12926	893	31	3	216	3	PYGL	14	51375033	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1286972	51375033	55974507	561	28408											
PYGL	5836	broad.mit.edu	37	chr14	51390809	51390809	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atatctgagccaatcatctgCttcttctacctgcaaaagga	12	12	6	11	0	5	1	1	1	4	0	5	2	5	2	2	1	4	2	2	1	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:51390809C>G	uc001wyu.2	-	5	665	c.538G>C	c.(538-540)GCA>CCA	p.A180P	PYGL_uc010tqq.1_Missense_Mutation_p.A146P|PYGL_uc001wyv.2_5'UTR|PYGL_uc010anz.1_5'UTR|PYGL_uc001wyw.3_Missense_Mutation_p.A180P	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	180					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CAATCATCTGCTTCTTCTACC	0.383													8	50					0	0	0	0	G	51390809	G	G	51390809	3	3	154	1	0	0	0	0	1	0	0	0	12926	797	28	4	2069	4	PYGL	14	51390809	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	15776	51390809	55958731	562	28409											
BMP4	652	broad.mit.edu	37	chr14	54417231	54417231	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctaatcctgacatgctggCcctggtgggtccgagtctga	6	10	14	11	1	1	2	0	2	1	0	3	3	3	2	3	4	1	2	3	4	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:54417231C>G	uc001xal.3	-	3	933	c.746G>C	c.(745-747)GGC>GCC	p.G249A	BMP4_uc010aoh.2_Missense_Mutation_p.G249A|BMP4_uc001xao.3_Missense_Mutation_p.G249A|BMP4_uc001xan.3_Missense_Mutation_p.G249A	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	249					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0						GACATGCTGGCCCTGGTGGGT	0.617													23	67					0	0	0	0	G	54417231	G	G	54417231	3	3	154	1	0	0	0	0	1	0	0	0	1465	739	26	4	484	4	BMP4	14	54417231	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3026422	54417231	52932309	563	28410											
C14orf149	112849	broad.mit.edu	37	chr14	59946014	59946014	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaatgcataaaatgcaccGccatatgcaatgtccaccat	16	8	5	12	1	0	0	0	0	0	0	1	0	1	0	4	0	3	3	4	0	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:59946014G>A	uc001xee.1	-	2	603	c.564C>T	c.(562-564)GGC>GGT	p.G188G	C14orf149_uc010trx.1_3'UTR	NM_144581	NP_653182	Q96EM0	PRCM_HUMAN	proline racemase-like	188							proline racemase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.14)	L-Proline(DB00172)	AAAATGCACCGCCATATGCAA	0.423													12	47					0	0	0	0	A	59946014	A	A	59946014	2	1	154	1	0	0	0	0	0	0	0	1	1758	1074	38	1		1	C14orf149	14	59946014	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5528783	59946014	47403526	564	28411											
KCNH5	27133	broad.mit.edu	37	chr14	63511873	63511873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctccaaaaatgtgttctgcGgtgccaccagccctctcttg	7	12	8	14	1	3	0	0	0	3	0	5	0	3	0	4	1	3	1	4	1	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:63511873G>A	uc001xfx.2	-	1	83	c.32C>T	c.(31-33)CCG>CTG	p.P11L	KCNH5_uc001xfy.2_Missense_Mutation_p.P11L|KCNH5_uc001xfz.1_Intron|KCNH5_uc001xga.2_Intron	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	11	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TGTGTTCTGCGGTGCCACCAG	0.517													7	61					0	0	0	0	A	63511873	A	A	63511873	3	1	154	1	0	0	0	0	1	0	0	0	8074	1116	39	1	3012	1	KCNH5	14	63511873	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3565859	63511873	43837667	565	28412											
PPP2R5E	5529	broad.mit.edu	37	chr14	64006301	64006301	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgccttgagacctaaactGtgaggaactttgcgacctct	9	12	9	11	1	1	2	0	2	1	1	1	5	1	3	3	1	4	0	3	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:64006301G>C	uc001xgd.1	-	2	693	c.103C>G	c.(103-105)CAG>GAG	p.Q35E	PPP2R5E_uc001xge.2_Missense_Mutation_p.Q35E|PPP2R5E_uc010tsh.1_Missense_Mutation_p.Q35E|PPP2R5E_uc001xgf.1_RNA|PPP2R5E_uc001xgg.3_Missense_Mutation_p.Q35E	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	35					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		GACCTAAACTGTGAGGAACTT	0.463													7	72					0	0	0	0	C	64006301	C	C	64006301	3	2	154	1	0	0	0	0	1	0	0	0	12456	1386	48	4	1352	4	PPP2R5E	14	64006301	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	494428	64006301	43343239	566	28413											
C14orf50	145376	broad.mit.edu	37	chr14	65041172	65041172	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttttttgtcctccccatcaGaggccttgtagagaaaaaag	11	13	8	9	0	1	2	1	0	0	2	3	3	3	2	4	1	0	1	4	1	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:65041172G>C	uc001xhl.1	+	8	630	c.534_splice	c.e8-1	p.V178_splice		NM_172365	NP_758953	Q96LQ0	CN050_HUMAN	hypothetical protein LOC145376											skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00382)|all cancers(60;0.00427)|BRCA - Breast invasive adenocarcinoma(234;0.0488)		CTCCCCATCAGAGGCCTTGTA	0.348													7	48					0	0	0	0	C	65041172	C	C	65041172	5	2	154	1	0	0	0	0	0	0	1	0	1783	956	33	2	563	2	C14orf50	14	65041172	Splice_Site	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1034871	65041172	42308368	567	28414											
SPTB	6710	broad.mit.edu	37	chr14	65261194	65261194	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttggtctcacctttcccctCggtgaacttcagggtggctg	4	13	11	13	1	2	1	2	1	1	0	5	1	3	1	3	4	1	1	3	4	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:65261194C>T	uc001xht.2	-	12	1840	c.1786G>A	c.(1786-1788)GAG>AAG	p.E596K	SPTB_uc001xhr.2_Missense_Mutation_p.E596K|SPTB_uc001xhs.2_Missense_Mutation_p.E596K|SPTB_uc001xhu.2_Missense_Mutation_p.E596K	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	596	Spectrin 3.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCTTTCCCCTCGGTGAACTTC	0.532													17	154					0	0	0	0	T	65261194	T	T	65261194	3	4	154	1	0	0	0	0	1	0	0	0	15184	893	31	1	5365	1	SPTB	14	65261194	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	220022	65261194	42088346	568	28415											
PCNX	22990	broad.mit.edu	37	chr14	71495434	71495434	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagccactacaagcctgcttGcagcactttacagttttatc	10	13	6	12	0	0	0	0	0	0	0	1	0	0	0	2	0	7	4	2	0	5	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:71495434G>C	uc001xmo.2	+	16	3930	c.3484G>C	c.(3484-3486)GCA>CCA	p.A1162P	PCNX_uc010are.1_Missense_Mutation_p.A1051P|PCNX_uc010arf.1_Missense_Mutation_p.A22P	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1162	Helical; (Potential).					integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AAGCCTGCTTGCAGCACTTTA	0.303													44	46					0	0	0	0	C	71495434	C	C	71495434	3	2	154	1	0	0	0	0	1	0	0	0	11645	1319	46	4	3546	4	PCNX	14	71495434	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	6234240	71495434	35854106	569	28416											
ABCD4	5826	broad.mit.edu	37	chr14	74759945	74759945	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtcctcatgtgctccacatgCccagctctgacaaggaaagg	10	8	10	13	0	2	1	1	1	1	0	4	2	4	2	3	2	3	2	3	2	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:74759945C>A	uc001xpr.2	-	8	878	c.726G>T	c.(724-726)GGG>GGT	p.G242G	ABCD4_uc001xps.2_Silent_p.G83G|ABCD4_uc001xpt.2_Silent_p.G83G|ABCD4_uc010tur.1_Silent_p.G138G|ABCD4_uc001xpu.2_Intron|ABCD4_uc001xpv.2_Intron	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	242	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		GCTCCACATGCCCAGCTCTGA	0.597													14	72					2.32078e-09	5.10631e-09	1	0	A	74759945	A	A	74759945	2	1	154	1	0	0	0	0	0	0	0	1	63	726	26	4		4	ABCD4	14	74759945	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3264511	74759945	32589595	570	28417											
YLPM1	56252	broad.mit.edu	37	chr14	75248679	75248679	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccacaagggatacctcctCagttaacagcagccccagtt	11	9	7	14	0	1	0	1	0	0	0	3	1	3	1	5	1	4	3	5	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:75248679C>A	uc001xqj.3	+	4	2057	c.1933C>A	c.(1933-1935)CAG>AAG	p.Q645K	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	450					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GATACCTCCTCAGTTAACAGC	0.547													16	48					1.3612e-06	2.8186e-06	1	0	A	75248679	A	A	75248679	3	1	154	1	0	0	0	0	1	0	0	0	17554	827	29	2	1947	2	YLPM1	14	75248679	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	488734	75248679	32100861	571	28418											
YLPM1	56252	broad.mit.edu	37	chr14	75248700	75248700	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agttaacagcagccccagttCcaccagcctccagttcacag	11	7	7	16	0	1	0	1	0	0	0	3	0	3	0	6	0	4	4	6	0	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:75248700C>T	uc001xqj.3	+	4	2078	c.1954C>T	c.(1954-1956)CCA>TCA	p.P652S	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGCCCCAGTTCCACCAGCCTC	0.547													15	47					0	0	0	0	T	75248700	T	T	75248700	3	4	154	1	0	0	0	0	1	0	0	0	17554	855	30	2	1968	2	YLPM1	14	75248700	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	21	75248700	32100840	572	28419											
EIF2B2	8892	broad.mit.edu	37	chr14	75473335	75473335	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggccctgagagctgtgacagGaactcacactctggcactgg	9	7	13	12	0	2	2	1	2	1	1	2	4	2	3	1	4	2	2	1	4	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:75473335G>C	uc001xrc.1	+	6	831	c.749G>C	c.(748-750)GGA>GCA	p.G250A		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	250					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		GCTGTGACAGGAACTCACACT	0.527													35	202					0	0	0	0	C	75473335	C	C	75473335	3	2	154	1	0	0	0	0	1	0	0	0	5023	1174	41	2	771	2	EIF2B2	14	75473335	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	224635	75473335	31876205	573	28420											
DYNC1H1	1778	broad.mit.edu	37	chr14	102500686	102500686	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtacagatattgccaggacgGaatacctttccaatgctgat	12	11	9	9	1	0	2	0	1	0	1	1	4	1	4	3	2	4	2	3	2	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr14:102500686G>C	uc001yks.2	+	56	10815	c.10651G>C	c.(10651-10653)GAA>CAA	p.E3551Q		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3551					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TGCCAGGACGGAATACCTTTC	0.502													6	68					0	0	0	0	C	102500686	C	C	102500686	3	2	154	1	0	0	0	0	1	0	0	0	4863	1175	41	2	10873	2	DYNC1H1	14	102500686	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	27027351	102500686	4848854	574	28421											
C15orf2	23742	broad.mit.edu	37	chr15	24923661	24923661	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcacaggcagataggagaCcaaccacaacttccagccat	14	5	8	14	0	0	2	0	0	0	2	1	3	1	2	4	2	4	2	4	2	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:24923661C>A	uc001ywo.2	+	1	3121	c.2647C>A	c.(2647-2649)CCA>ACA	p.P883T		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	883					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AGATAGGAGACCAACCACAAC	0.483													16	122					6.31663e-08	1.34114e-07	1	0	A	24923661	A	A	24923661	3	1	154	1	0	0	0	0	1	0	0	0	1790	507	18	4	2649	4	C15orf2	15	24923661	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08		24923661	77607731	575	28422											
ATP10A	57194	broad.mit.edu	37	chr15	25953204	25953204	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccagggaggattcggcttCtaggtggctttgcaaccagc	7	11	13	10	1	1	0	0	0	1	0	3	2	2	2	2	5	3	3	2	5	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:25953204C>G	uc010ayu.2	-	12	2600	c.2494G>C	c.(2494-2496)GAA>CAA	p.E832Q		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	832	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GATTCGGCTTCTAGGTGGCTT	0.537													9	48					0	0	0	0	G	25953204	G	G	25953204	3	3	154	1	0	0	0	0	1	0	0	0	1118	922	32	2	2045	2	ATP10A	15	25953204	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1029543	25953204	76578188	576	28423											
ARHGAP11A	9824	broad.mit.edu	37	chr15	32929051	32929051	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caactataaaatgttattcaActcagatgaagatggaacat	18	11	6	6	0	2	3	2	1	0	2	2	4	2	4	0	1	3	1	0	1	8	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:32929051A>T	uc001zgy.1	+	12	2799	c.2077A>T	c.(2077-2079)ACT>TCT	p.T693S	ARHGAP11A_uc010ubw.1_Missense_Mutation_p.T504S|ARHGAP11A_uc010ubx.1_Missense_Mutation_p.T504S	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	693					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		ATGTTATTCAACTCAGATGAA	0.318													4	24					0	0	0	0	T	32929051	T	T	32929051	3	4	154	1	0	0	0	0	1	0	0	0	863	43	2	5	2146	5	ARHGAP11A	15	32929051	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	6975847	32929051	69602341	577	28424											
DUOXA1	90527	broad.mit.edu	37	chr15	45409770	45409770	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaggctccaaaagatggaaGaaggcccgggcatcacgcct	12	5	13	11	2	1	2	1	0	0	2	2	3	2	3	3	4	0	3	3	4	5	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:45409770G>C	uc001zup.2	-	11	1795	c.1395C>G	c.(1393-1395)TTC>TTG	p.F465L	DUOXA2_uc001zuo.2_Intron|DUOXA2_uc010beb.2_Intron|DUOXA1_uc010uem.1_Missense_Mutation_p.F420L|DUOXA1_uc010bec.2_Missense_Mutation_p.F465L	NM_144565	NP_653166	Q1HG43	DOXA1_HUMAN	Numb-interacting protein	Error:Variant_position_missing_in_Q1HG43_after_alignment					protein transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		AAAGATGGAAGAAGGCCCGGG	0.224													4	7					0	0	0	0	C	45409770	C	C	45409770	3	2	154	1	0	0	0	0	1	0	0	0	4824	933	33	2	60	2	DUOXA1	15	45409770	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	12480719	45409770	57121622	578	28425											
GALK2	2585	broad.mit.edu	37	chr15	49584728	49584728	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatcctgagtccaaacactCaagatggtgagttggctgga	13	9	11	8	0	1	3	1	2	0	1	3	4	3	4	2	3	1	2	2	3	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:49584728C>G	uc001zxj.1	+	8	1059	c.961C>G	c.(961-963)CAA>GAA	p.Q321E	GALK2_uc001zxi.1_Missense_Mutation_p.Q310E|GALK2_uc010ufb.1_Missense_Mutation_p.Q297E|GALK2_uc001zxk.2_RNA|GALK2_uc010ufc.1_Missense_Mutation_p.Q297E	NM_002044	NP_002035	Q01415	GALK2_HUMAN	galactokinase 2 isoform 1	321					galactose metabolic process	cytoplasm	ATP binding|galactokinase activity|N-acetylgalactosamine kinase activity			breast(1)	1		all_lung(180;0.000325)		all cancers(107;3.71e-08)|GBM - Glioblastoma multiforme(94;7e-05)		TCCAAACACTCAAGATGGTGA	0.458													6	32					0	0	0	0	G	49584728	G	G	49584728	3	3	154	1	0	0	0	0	1	0	0	0	6239	827	29	2	1015	2	GALK2	15	49584728	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4174958	49584728	52946664	579	28426											
SLTM	79811	broad.mit.edu	37	chr15	59209166	59209166	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcatcttccacagaagcatCtccactcaactcatctgctt	11	12	3	15	0	6	1	3	0	3	1	8	1	7	1	2	0	3	2	2	0	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:59209166C>G	uc002afp.2	-	3	371	c.283G>C	c.(283-285)GAT>CAT	p.D95H	SLTM_uc002afo.2_Missense_Mutation_p.D95H|SLTM_uc002afq.2_5'UTR|SLTM_uc010bgd.2_5'UTR|SLTM_uc002afr.1_Missense_Mutation_p.D95H	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	95					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						ACAGAAGCATCTCCACTCAAC	0.323													3	19					0	0	0	0	G	59209166	G	G	59209166	3	3	154	1	0	0	0	0	1	0	0	0	14818	913	32	2	2897	2	SLTM	15	59209166	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	9624438	59209166	43322226	580	28427											
CILP	8483	broad.mit.edu	37	chr15	65497636	65497636	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtggtacctgtacagtccTggcccatgcagtgctgaccc	6	9	13	13	0	0	1	0	1	0	0	1	1	1	1	4	3	4	4	4	3	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:65497636T>A	uc002aon.2	-	5	774	c.593A>T	c.(592-594)CAG>CTG	p.Q198L		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	198	TSP type-1.				negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TGTACAGTCCTGGCCCATGCA	0.592													19	96					0	0	0	0	A	65497636	A	A	65497636	3	1	154	1	0	0	0	0	1	0	0	0	3444	1580	55	5	2981	5	CILP	15	65497636	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	6288470	65497636	37033756	581	28428											
CSPG4	1464	broad.mit.edu	37	chr15	75977614	75977614	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaggtccgtcctccttctgCagggctccatgctggggtgg	3	11	15	12	1	1	1	0	1	1	0	5	1	5	1	4	5	2	3	4	5	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:75977614C>T	uc002baw.2	-	4	4311	c.4218G>A	c.(4216-4218)CTG>CTA	p.L1406L		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1406	CSPG 9.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CCTCCTTCTGCAGGGCTCCAT	0.672													5	56					0	0	0	0	T	75977614	T	T	75977614	2	4	154	1	0	0	0	0	0	0	0	1	3977	697	25	4		4	CSPG4	15	75977614	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	10479978	75977614	26553778	582	28429											
RASGRF1	5923	broad.mit.edu	37	chr15	79320138	79320138	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcacagccttcgatgatCatgcgctcgatggccaggtt	8	11	10	12	3	2	1	2	1	1	0	5	3	2	1	2	2	2	2	2	2	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:79320138C>A	uc002beq.2	-	9	1701	c.1326G>T	c.(1324-1326)ATG>ATT	p.M442I	RASGRF1_uc002bep.2_Missense_Mutation_p.M442I|RASGRF1_uc010blm.1_Missense_Mutation_p.M364I|RASGRF1_uc002ber.3_Missense_Mutation_p.M442I	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	442					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						CTTCGATGATCATGCGCTCGA	0.562													6	102					2.0095e-06	4.12217e-06	1	0	A	79320138	A	A	79320138	3	1	154	1	0	0	0	0	1	0	0	0	13137	826	29	2	2575	2	RASGRF1	15	79320138	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3342524	79320138	23211254	583	28430											
FAM108C1	58489	broad.mit.edu	37	chr15	81041863	81041863	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttctccaggtatggcgtGagtcccgagaacattatcct	9	12	10	10	2	1	2	0	1	1	1	4	4	3	2	3	2	1	1	3	2	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:81041863G>T	uc002bfu.2	+	2	719	c.600G>T	c.(598-600)GTG>GTT	p.V200V	FAM108C1_uc002bft.2_Silent_p.V193V	NM_021214	NP_067037	Q6PCB6	F108C_HUMAN	hypothetical protein LOC58489	200							hydrolase activity				0						GGTATGGCGTGAGTCCCGAGA	0.483													8	70					3.09899e-07	6.50898e-07	1	0	T	81041863	T	T	81041863	2	4	154	1	0	0	0	0	0	0	0	1	5421	1277	45	2		2	FAM108C1	15	81041863	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1721725	81041863	21489529	584	28431											
KIAA1199	57214	broad.mit.edu	37	chr15	81225753	81225753	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccggcacccagactgcatCaatgttcccgactggagagg	9	7	12	13	2	1	2	1	0	0	2	3	4	3	2	3	3	1	3	3	3	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:81225753C>G	uc002bfw.1	+	22	3221	c.2961C>G	c.(2959-2961)ATC>ATG	p.I987M	KIAA1199_uc010unn.1_Missense_Mutation_p.I987M	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	987										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CAGACTGCATCAATGTTCCCG	0.542													16	65					0	0	0	0	G	81225753	G	G	81225753	3	3	154	1	0	0	0	0	1	0	0	0	8252	816	29	2	3043	2	KIAA1199	15	81225753	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	183890	81225753	21305639	585	28432											
ACAN	176	broad.mit.edu	37	chr15	89414699	89414699	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgagacctgggtggatgctGagcgccggtgtcgggagcag	6	6	20	9	4	0	2	0	1	0	1	1	5	0	4	2	4	3	2	2	4	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:89414699G>A	uc010upo.1	+	14	7407	c.7033G>A	c.(7033-7035)GAG>AAG	p.E2345K	ACAN_uc010upp.1_Missense_Mutation_p.E2307K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2345					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGTGGATGCTGAGCGCCGGTG	0.637													5	32					0	0	0	0	A	89414699	A	A	89414699	3	1	154	1	0	0	0	0	1	0	0	0	117	1291	45	2	7083	2	ACAN	15	89414699	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	8188946	89414699	13116693	586	28433											
ST8SIA2	8128	broad.mit.edu	37	chr15	92981809	92981809	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgaacagcggctgtgggCaggagattgacgcccacagc	9	6	15	11	2	0	3	0	2	0	1	0	4	0	3	1	3	4	3	1	3	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:92981809C>T	uc002bra.2	+	4	672	c.517C>T	c.(517-519)CAG>TAG	p.Q173*	ST8SIA2_uc002brb.2_Nonsense_Mutation_p.Q152*	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	173	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			CGGCTGTGGGCAGGAGATTGA	0.602													5	40					0	0	0	0	T	92981809	T	T	92981809	4	4	154	1	0	0	0	0	0	1	0	0	15298	711	25	4	531	4	ST8SIA2	15	92981809	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3567110	92981809	9549583	587	28434											
MCTP2	55784	broad.mit.edu	37	chr15	94901811	94901811	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgaagtgtggggaaaggAcaacaaaaagcatgaggaac	18	5	13	5	0	0	2	0	2	0	0	0	5	0	5	0	4	3	1	0	4	6	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:94901811A>T	uc002btj.2	+	9	1336	c.1271A>T	c.(1270-1272)GAC>GTC	p.D424V	MCTP2_uc010urg.1_3'UTR|MCTP2_uc002bti.2_Missense_Mutation_p.D424V|MCTP2_uc010boj.2_Missense_Mutation_p.D153V|MCTP2_uc010bok.2_Missense_Mutation_p.D424V|MCTP2_uc002btk.3_Missense_Mutation_p.D12V|MCTP2_uc002btl.2_Missense_Mutation_p.D12V	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	424	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TGGGGAAAGGACAACAAAAAG	0.502													6	21					0	0	0	0	T	94901811	T	T	94901811	3	4	154	1	0	0	0	0	1	0	0	0	9454	275	10	5	1305	5	MCTP2	15	94901811	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	1920002	94901811	7629581	588	28435											
TARSL2	123283	broad.mit.edu	37	chr15	102215919	102215919	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattgcaaaaactgcaaacAcccctttatttcttcttcaa	14	13	3	11	0	3	1	1	0	2	1	3	1	3	1	2	0	4	2	2	0	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr15:102215919A>T	uc002bxm.2	-	13	1727	c.1672T>A	c.(1672-1674)TGT>AGT	p.C558S	TARSL2_uc002bxl.2_Missense_Mutation_p.C103S|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	558					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AACTGCAAACACCCCTTTATT	0.328													19	47					0	0	0	0	T	102215919	T	T	102215919	3	4	154	1	0	0	0	0	1	0	0	0	15627	159	6	5	764	5	TARSL2	15	102215919	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	7314108	102215919	315473	589	28436											
CRAMP1L	57585	broad.mit.edu	37	chr16	1720768	1720768	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttgttggatggaaactcGcgggactcatttgtgtccag	8	12	13	8	2	1	0	1	0	0	0	3	3	2	3	1	3	2	2	1	3	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:1720768G>C	uc010uvh.1	+	19	3603	c.3603G>C	c.(3601-3603)TCG>TCC	p.S1201S	CRAMP1L_uc002cmf.2_RNA	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	1201	Ser-rich.					nucleus	DNA binding				0						ATGGAAACTCGCGGGACTCAT	0.582													12	65					0	0	0	0	C	1720768	C	C	1720768	2	2	154	1	0	0	0	0	0	0	0	1	3861	1074	38	3		3	CRAMP1L	16	1720768	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08		1720768	88633985	590	28437											
PKD1	5310	broad.mit.edu	37	chr16	2159507	2159507	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccacagcaccaggcccacGatgggctcctccgccgtgag	7	4	12	18	3	0	1	0	1	0	0	2	2	2	1	6	2	1	2	6	2	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:2159507G>A	uc002cos.1	-	15	5870	c.5661C>T	c.(5659-5661)ATC>ATT	p.I1887I	PKD1_uc002cot.1_Silent_p.I1887I	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1887	PKD 14.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCAGGCCCACGATGGGCTCCT	0.652													4	21					0	0	0	0	A	2159507	A	A	2159507	2	1	154	1	0	0	0	0	0	0	0	1	12018	1048	37	1		1	PKD1	16	2159507	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	438739	2159507	88195246	591	28438											
ZNF213	7760	broad.mit.edu	37	chr16	3187533	3187533	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgcgtaccaaggagcagatCctggagctgctggtgctgga	8	8	15	10	1	0	1	0	0	0	1	1	4	1	4	2	4	6	5	2	4	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:3187533C>G	uc010uws.1	+	2	699	c.252C>G	c.(250-252)ATC>ATG	p.I84M	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_Missense_Mutation_p.I84M|ZNF213_uc010bth.2_Missense_Mutation_p.I84M|ZNF213_uc010uwt.1_Missense_Mutation_p.I84M	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	84	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGGAGCAGATCCTGGAGCTGC	0.662													9	61					0	0	0	0	G	3187533	G	G	3187533	3	3	154	1	0	0	0	0	1	0	0	0	17836	845	30	2	254	2	ZNF213	16	3187533	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1028026	3187533	87167220	592	28439											
MEFV	4210	broad.mit.edu	37	chr16	3304450	3304450	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcctccccgcggagctggcGtttctgcgcagccggacctc	4	7	13	17	5	1	0	0	0	1	0	3	2	2	2	5	3	4	3	5	3	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:3304450G>A	uc002cun.1	-	2	658	c.618C>T	c.(616-618)AAC>AAT	p.N206N		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	206					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	CGGAGCTGGCGTTTCTGCGCA	0.756													10	40					0	0	0	0	A	3304450	A	A	3304450	2	1	154	1	0	0	0	0	0	0	0	1	9512	1136	40	1		1	MEFV	16	3304450	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	116917	3304450	87050303	593	28440											
ZNF597	146434	broad.mit.edu	37	chr16	3487315	3487315	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattcagagagttctactaaTggggtgtggttttcaatggt	9	16	12	4	0	3	1	2	0	1	1	3	2	3	1	0	4	1	2	0	4	4	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:3487315T>A	uc002cvd.2	-	4	568	c.384A>T	c.(382-384)CCA>CCT	p.P128P		NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	zinc finger protein 597	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTTCTACTAATGGGGTGTGGT	0.413													24	76					0	0	0	0	A	3487315	A	A	3487315	2	1	154	1	0	0	0	0	0	0	0	1	18094	1451	51	5		5	ZNF597	16	3487315	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	182865	3487315	86867438	594	28441											
BTBD12	84464	broad.mit.edu	37	chr16	3633428	3633428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctctcgtcctcggagtctGagtccagggtctggtgagtg	4	11	16	10	2	3	2	0	2	3	0	7	3	5	3	2	4	0	1	2	4	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:3633428G>A	uc002cvp.2	-	14	5450	c.4823C>T	c.(4822-4824)TCA>TTA	p.S1608L		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1608	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CTCGGAGTCTGAGTCCAGGGT	0.597								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				8	122					0	0	0	0	A	3633428	A	A	3633428	3	1	154	1	0	0	0	0	1	0	0	0	1545	1294	45	2	689	2	BTBD12	16	3633428	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	146113	3633428	86721325	595	28442											
ABAT	18	broad.mit.edu	37	chr16	8860098	8860098	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcagaggggcttctcccagGaggagctggagacgtgcatg	8	6	18	9	1	1	2	0	0	1	2	2	5	1	4	1	6	2	4	1	6	0	1	rs139121258	by1000genomes	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:8860098G>A	uc002czc.3	+	9	740	c.574G>A	c.(574-576)GAG>AAG	p.E192K	ABAT_uc002czd.3_Missense_Mutation_p.E192K|ABAT_uc010buh.2_Missense_Mutation_p.E134K|ABAT_uc010bui.2_Missense_Mutation_p.E192K	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	192					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	CTTCTCCCAGGAGGAGCTGGA	0.552													9	26					0	0	0	0	A	8860098	A	A	8860098	3	1	154	1	0	0	0	0	1	0	0	0	27	1175	41	2	604	2	ABAT	16	8860098	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5226670	8860098	81494655	596	28443											
RRN3	54700	broad.mit.edu	37	chr16	15179505	15179505	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttatacttactatcatcttCatcatcagaatctgaaacat	14	16	2	9	0	6	2	4	1	2	1	6	2	6	2	0	0	3	0	0	0	6	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:15179505C>T	uc002dde.2	-	6	591	c.523G>A	c.(523-525)GAA>AAA	p.E175K	PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Missense_Mutation_p.E76K|RRN3_uc010uzq.1_Missense_Mutation_p.E145K|RRN3_uc002ddf.1_Missense_Mutation_p.E175K	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor	175					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1						CTATCATCTTCATCATCAGAA	0.224													5	26					0	0	0	0	T	15179505	T	T	15179505	3	4	154	1	0	0	0	0	1	0	0	0	13749	835	29	2	1484	2	RRN3	16	15179505	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6319407	15179505	75175248	597	28444											
MYH11	4629	broad.mit.edu	37	chr16	15833949	15833949	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcatccatgaccaggatctCatcctccagtttcttgatct	9	14	5	13	0	4	2	2	2	3	0	8	3	7	3	4	1	0	1	4	1	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:15833949C>T	uc002ddy.2	-	23	3063	c.2956G>A	c.(2956-2958)GAG>AAG	p.E986K	MYH11_uc002ddv.2_Missense_Mutation_p.E993K|MYH11_uc002ddw.2_Missense_Mutation_p.E986K|MYH11_uc002ddx.2_Missense_Mutation_p.E993K|MYH11_uc010bvg.2_Missense_Mutation_p.E818K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	986	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						ACCAGGATCTCATCCTCCAGT	0.363			T	CBFB	AML								7	119					0	0	0	0	T	15833949	T	T	15833949	3	4	154	1	0	0	0	0	1	0	0	0	10084	835	29	2	3073	2	MYH11	16	15833949	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	654444	15833949	74520804	598	28445											
GP2	2813	broad.mit.edu	37	chr16	20329553	20329553	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtcagccttgtcttcagTgggggtggcatagcagttcc	7	11	14	9	0	3	0	2	0	1	0	4	0	4	0	2	4	2	3	2	4	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:20329553T>G	uc002dgv.2	-	8	1299	c.1216A>C	c.(1216-1218)ACT>CCT	p.T406P	GP2_uc002dgw.2_Missense_Mutation_p.T403P|GP2_uc002dgx.2_Missense_Mutation_p.T259P|GP2_uc002dgy.2_Missense_Mutation_p.T256P	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	406	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						TTGTCTTCAGTGGGGGTGGCA	0.468													7	48					0	0	0	0	G	20329553	G	G	20329553	3	3	154	1	0	0	0	0	1	0	0	0	6620	1696	59	5	417	5	GP2	16	20329553	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	4495604	20329553	70025200	599	28446											
SCNN1G	6340	broad.mit.edu	37	chr16	23226476	23226476	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagctgctctgttgtctgcGtcatcgagatcatcgaggtc	6	13	12	10	3	4	2	2	1	2	1	7	4	4	2	0	1	3	3	0	1	0	1	rs143742457		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:23226476G>A	uc002dlm.1	+	13	1775	c.1636G>A	c.(1636-1638)GTC>ATC	p.V546I		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	546	Helical; (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TGTTGTCTGCGTCATCGAGAT	0.552													12	54					0	0	0	0	A	23226476	A	A	23226476	3	1	154	1	0	0	0	0	1	0	0	0	13995	1145	40	1	1682	1	SCNN1G	16	23226476	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2896923	23226476	67128277	600	28447											
GTF3C1	2975	broad.mit.edu	37	chr16	27561184	27561184	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gagcccctccagagcgacttCgtccaacaacgactccagcg	10	5	9	17	4	0	1	0	0	0	1	4	4	3	1	5	0	5	0	5	0	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:27561184C>G	uc002dov.1	-	1	68	c.28G>C	c.(28-30)GAA>CAA	p.E10Q	GTF3C1_uc002dou.2_Missense_Mutation_p.E10Q|KIAA0556_uc002dow.2_5'Flank	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	10						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						AGAGCGACTTCGTCCAACAAC	0.687													10	23					0	0	0	0	G	27561184	G	G	27561184	3	3	154	1	0	0	0	0	1	0	0	0	6911	893	31	3	6449	3	GTF3C1	16	27561184	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	4334708	27561184	62793569	601	28448											
MYST1	84148	broad.mit.edu	37	chr16	31131716	31131716	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctggcgctgaccaagacaGtgaaggatgctgtacagaag	12	6	15	8	1	0	4	0	2	0	2	0	5	0	5	1	3	2	4	1	3	4	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:31131716G>T	uc002eay.2	+	3	361	c.343G>T	c.(343-345)GTG>TTG	p.V115L	MYST1_uc002eax.2_Missense_Mutation_p.V115L	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	115	Chromo.				histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1						GACCAAGACAGTGAAGGATGC	0.557													23	41					1.64293e-13	3.86133e-13	1	0	T	31131716	T	T	31131716	3	4	154	1	0	0	0	0	1	0	0	0	10155	1029	36	4	353	4	MYST1	16	31131716	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3570532	31131716	59223037	602	28449											
ITGAM	3684	broad.mit.edu	37	chr16	31308844	31308844	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtctctttcagatcggcgccTacttcggggcctccctctgc	3	12	10	16	3	3	1	1	0	2	1	7	1	4	1	3	3	2	0	3	3	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:31308844T>C	uc002ebq.2	+	13	1464	c.1366T>C	c.(1366-1368)TAC>CAC	p.Y456H	ITGAM_uc002ebr.2_Missense_Mutation_p.Y456H|ITGAM_uc010cam.1_Missense_Mutation_p.L59P|ITGAM_uc010can.2_5'UTR	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	456	FG-GAP 5.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GATCGGCGCCTACTTCGGGGC	0.587													35	162					0	0	0	0	C	31308844	C	C	31308844	3	2	154	1	0	0	0	0	1	0	0	0	7926	1522	53	5	1416	5	ITGAM	16	31308844	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	177128	31308844	59045909	603	28450											
TGFB1I1	7041	broad.mit.edu	37	chr16	31487345	31487345	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcgcaggtggtgacggctCtgggccgcgcctggcacccc	4	6	15	16	4	1	1	0	1	1	0	2	1	1	1	4	5	0	3	4	5	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:31487345C>G	uc002ecd.1	+	8	753	c.727C>G	c.(727-729)CTG>GTG	p.L243V	TGFB1I1_uc002ece.1_Missense_Mutation_p.L226V|TGFB1I1_uc010caq.1_Missense_Mutation_p.L82V	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	243	LIM zinc-binding 1.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						GGTGACGGCTCTGGGCCGCGC	0.647													15	52					0	0	0	0	G	31487345	G	G	31487345	3	3	154	1	0	0	0	0	1	0	0	0	15883	912	32	2	757	2	TGFB1I1	16	31487345	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	178501	31487345	58867408	604	28451											
ABCC12	94160	broad.mit.edu	37	chr16	48145806	48145806	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctaataaaataacttcatCacaagactctaagaactgca	18	11	3	9	0	4	2	2	0	2	2	4	2	4	2	0	0	3	1	0	0	7	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:48145806C>G	uc002efc.1	-	14	2351	c.2005G>C	c.(2005-2007)GAT>CAT	p.D669H	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	669	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				ATAACTTCATCACAAGACTCT	0.393													6	33					0	0	0	0	G	48145806	G	G	48145806	3	3	154	1	0	0	0	0	1	0	0	0	52	826	29	2	2138	2	ABCC12	16	48145806	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	16658461	48145806	42208947	605	28452											
CDH8	1006	broad.mit.edu	37	chr16	61851473	61851473	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcatgaacttcaagtaggTaagtcggtgaagagaagacc	14	10	11	6	1	2	4	2	2	0	2	3	5	2	4	1	2	1	2	1	2	6	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:61851473T>C	uc002eog.1	-	7	1439	c.1187A>G	c.(1186-1188)TAC>TGC	p.Y396C	CDH8_uc002eoh.2_Missense_Mutation_p.Y165C	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	396	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTCAAGTAGGTAAGTCGGTGA	0.483													9	39					0	0	0	0	C	61851473	C	C	61851473	3	2	154	1	0	0	0	0	1	0	0	0	3131	1638	57	5	1236	5	CDH8	16	61851473	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	13705667	61851473	28503280	606	28453											
C16orf70	80262	broad.mit.edu	37	chr16	67173918	67173918	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctattagcagatgccaaGatgcgggtatttgaacgttc	10	11	12	8	2	0	3	0	1	0	2	1	3	0	3	2	2	4	3	2	2	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:67173918G>A	uc002erc.2	+	10	777	c.693G>A	c.(691-693)AAG>AAA	p.K231K	C16orf70_uc002erd.2_Silent_p.K231K	NM_025187	NP_079463	Q9BSU1	CP070_HUMAN	lin-10	231										ovary(2)	2		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		CAGATGCCAAGATGCGGGTAT	0.473													10	198					0	0	0	0	A	67173918	A	A	67173918	2	1	154	1	0	0	0	0	0	0	0	1	1835	933	33	2		2	C16orf70	16	67173918	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	5322445	67173918	23180835	607	28454											
HSD11B2	3291	broad.mit.edu	37	chr16	67470691	67470691	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctgctggcagctcggcccCgccgccgctattaccccggc	3	6	12	20	6	0	0	0	0	0	0	1	0	0	0	6	3	3	5	6	3	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:67470691C>T	uc002etd.2	+	5	1119	c.1003C>T	c.(1003-1005)CGC>TGC	p.R335C		NM_000196	NP_000187	P80365	DHI2_HUMAN	hydroxysteroid (11-beta) dehydrogenase 2	335					glucocorticoid biosynthetic process	endoplasmic reticulum|microsome					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0401)|Epithelial(162;0.0891)	NADH(DB00157)	AGCTCGGCCCCGCCGCCGCTA	0.637													17	140					0	0	0	0	T	67470691	T	T	67470691	3	4	154	1	0	0	0	0	1	0	0	0	7416	652	23	1	1021	1	HSD11B2	16	67470691	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	296773	67470691	22884062	608	28455											
CYB5B	80777	broad.mit.edu	37	chr16	69458700	69458700	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggcaaagcgcaactccttGaaggaactgtggcttgtgat	10	10	13	8	1	0	2	0	2	0	0	1	3	1	3	1	3	3	3	1	3	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:69458700G>C	uc002exg.1	+	1	203	c.114G>C	c.(112-114)TTG>TTC	p.L38F	CYB5B_uc002exf.2_Missense_Mutation_p.L38F|CYB5B_uc010cfl.1_Missense_Mutation_p.L38F	NM_030579	NP_085056	O43169	CYB5B_HUMAN	cytochrome b5 outer mitochondrial membrane	34	Cytochrome b5 heme-binding.				electron transport chain|transport	integral to membrane|mitochondrial outer membrane	heme binding				0		Ovarian(137;0.101)				GCAACTCCTTGAAGGAACTGT	0.607													4	54					0	0	0	0	C	69458700	C	C	69458700	3	2	154	1	0	0	0	0	1	0	0	0	4140	1281	45	2	116	2	CYB5B	16	69458700	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1988009	69458700	20896053	609	28456											
CYB5B	80777	broad.mit.edu	37	chr16	69458737	69458737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgatccatgggcgagtctacGatgtcacccgcttcctcaac	8	10	9	14	3	3	1	2	1	1	0	5	3	5	1	3	1	2	1	3	1	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:69458737G>A	uc002exg.1	+	1	240	c.151G>A	c.(151-153)GAT>AAT	p.D51N	CYB5B_uc002exf.2_Missense_Mutation_p.D51N|CYB5B_uc010cfl.1_Missense_Mutation_p.D51N	NM_030579	NP_085056	O43169	CYB5B_HUMAN	cytochrome b5 outer mitochondrial membrane	47	Cytochrome b5 heme-binding.				electron transport chain|transport	integral to membrane|mitochondrial outer membrane	heme binding				0		Ovarian(137;0.101)				GCGAGTCTACGATGTCACCCG	0.587													5	40					0	0	0	0	A	69458737	A	A	69458737	3	1	154	1	0	0	0	0	1	0	0	0	4140	1058	37	1	153	1	CYB5B	16	69458737	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	37	69458737	20896016	610	28457											
SF3B3	23450	broad.mit.edu	37	chr16	70573046	70573046	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatattttgatactgtacccGttgctgctgccatgtgtgtg	7	16	10	8	1	0	1	0	1	0	0	0	1	0	1	2	0	5	4	2	0	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:70573046G>T	uc002ezf.2	+	8	1214	c.1003G>T	c.(1003-1005)GTT>TTT	p.V335F		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	335					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				TACTGTACCCGTTGCTGCTGC	0.423													43	90					2.215e-12	5.12835e-12	1	0	T	70573046	T	T	70573046	3	4	154	1	0	0	0	0	1	0	0	0	14217	1145	40	3	1029	3	SF3B3	16	70573046	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1114309	70573046	19781707	611	28458											
HYDIN	54768	broad.mit.edu	37	chr16	71015349	71015349	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaagattccctctccgctCagagtgatattttctgggtc	8	13	10	10	1	3	3	1	1	2	2	6	4	4	4	2	2	0	1	2	2	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:71015349C>G	uc002ezr.2	-	29	4580	c.4452G>C	c.(4450-4452)CTG>CTC	p.L1484L		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1485										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCTCTCCGCTCAGAGTGATAT	0.483													10	63					0	0	0	0	G	71015349	G	G	71015349	2	3	154	1	0	0	0	0	0	0	0	1	7506	813	29	2		2	HYDIN	16	71015349	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	442303	71015349	19339404	612	28459											
PMFBP1	83449	broad.mit.edu	37	chr16	72158692	72158692	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgtcctcaaggaggttctCttttaaggcggccatctcct	7	13	9	12	2	3	0	1	0	2	0	7	1	4	1	3	4	0	1	3	4	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:72158692C>A	uc002fcc.3	-	17	2750	c.2578G>T	c.(2578-2580)GAG>TAG	p.E860*	PMFBP1_uc002fcd.2_Nonsense_Mutation_p.E855*|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Nonsense_Mutation_p.E710*|PMFBP1_uc010cgo.1_Nonsense_Mutation_p.E151*	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	860	Potential.									ovary(2)	2		Ovarian(137;0.179)				AGGAGGTTCTCTTTTAAGGCG	0.567											OREG0023927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	138					8.00594e-06	1.61961e-05	1	0	A	72158692	A	A	72158692	4	1	154	1	0	0	0	0	0	1	0	0	12189	922	32	2	540	2	PMFBP1	16	72158692	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1143343	72158692	18196061	613	28460											
MLKL	197259	broad.mit.edu	37	chr16	74716632	74716632	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccctatccaacagctccctCagggtcccgagttcacagta	9	9	7	16	1	2	0	2	0	0	0	6	1	6	0	4	1	2	3	4	1	3	3	rs150099936		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:74716632C>G	uc002fdb.2	-	6	1314	c.873G>C	c.(871-873)CTG>CTC	p.L291L	MLKL_uc002fdc.2_Intron	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	291	Protein kinase.		L -> P (in a gastric adenocarcinoma sample; somatic mutation).				ATP binding|protein binding|protein kinase activity	p.L291P(1)		stomach(2)	2						ACAGCTCCCTCAGGGTCCCGA	0.557													3	53					0	0	0	0	G	74716632	G	G	74716632	2	3	154	1	0	0	0	0	0	0	0	1	9672	813	29	2		2	MLKL	16	74716632	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2557940	74716632	15638121	614	28461											
TMEM170A	124491	broad.mit.edu	37	chr16	75481557	75481557	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtatcatttccttccctgCtgctcggtaaactccagcaa	8	13	7	13	1	1	0	1	0	0	0	5	0	4	0	3	2	4	5	3	2	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr16:75481557C>A	uc002fee.1	-	3	420	c.334G>T	c.(334-336)GCA>TCA	p.A112S	TMEM170A_uc002feb.2_Missense_Mutation_p.A74S|TMEM170A_uc002fec.2_Missense_Mutation_p.A89S|TMEM170A_uc002fed.1_RNA	NM_145254	NP_660297	Q8WVE7	T170A_HUMAN	transmembrane protein 170A	112	Extracellular (Potential).					integral to membrane					0						TCCTTCCCTGCTGCTCGGTAA	0.398													14	73					7.93312e-07	1.64851e-06	1	0	A	75481557	A	A	75481557	3	1	154	1	0	0	0	0	1	0	0	0	16152	797	28	4	104	4	TMEM170A	16	75481557	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	764925	75481557	14873196	615	28462											
PITPNA	5306	broad.mit.edu	37	chr17	1437393	1437393	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccccagagcccccacttacTtcatccagctgtctcttcgt	6	11	5	19	1	2	1	1	0	1	1	5	1	3	1	5	0	3	1	5	0	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:1437393T>C	uc002fst.3	-	9	1024	c.768A>G	c.(766-768)GAA>GAG	p.E256E	PITPNA_uc010cjt.2_Silent_p.E140E|PITPNA_uc010cju.2_Silent_p.E154E	NM_006224	NP_006215	Q00169	PIPNA_HUMAN	phosphatidylinositol transfer protein, alpha	256					axon guidance|lipid metabolic process|visual perception	cytoplasm	phosphatidylcholine transmembrane transporter activity|phosphatidylinositol transporter activity|protein binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0845)		CCCCACTTACTTCATCCAGCT	0.502													4	295					0	0	0	0	C	1437393	C	C	1437393	2	2	154	1	0	0	0	0	0	0	0	1	12002	1623	56	5		5	PITPNA	17	1437393	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08		1437393	79757817	616	28463											
CTNS	1497	broad.mit.edu	37	chr17	3561357	3561357	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggtgctcgcgtggctctTcgcatttgtcaccatgatcg	4	13	11	13	4	2	1	1	1	1	0	5	1	2	1	2	2	1	3	2	2	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:3561357T>C	uc002fwb.2	+	10	1333	c.740T>C	c.(739-741)TTC>TCC	p.F247S	CTNS_uc002fwa.2_Missense_Mutation_p.F247S|CTNS_uc010ckj.2_Missense_Mutation_p.F247S|CTNS_uc010vrv.1_Missense_Mutation_p.F100S|CTNS_uc010vrw.1_Missense_Mutation_p.F139S	NM_004937	NP_004928	O60931	CTNS_HUMAN	cystinosin isoform 2	247	Helical; (Potential).				ATP metabolic process|brain development|cognition|glutathione metabolic process	integral to membrane|late endosome|lysosomal membrane	L-cystine transmembrane transporter activity				0				COAD - Colon adenocarcinoma(5;0.0829)	L-Cystine(DB00138)	GCGTGGCTCTTCGCATTTGTC	0.622													38	81					0	0	0	0	C	3561357	C	C	3561357	3	2	154	1	0	0	0	0	1	0	0	0	4038	1783	62	5	770	5	CTNS	17	3561357	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	2123964	3561357	77633853	617	28464											
SPNS3	201305	broad.mit.edu	37	chr17	4389751	4389751	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccctgactcctatctgcaGcgcttccgcagcctgcagca	6	8	9	18	3	1	1	0	1	1	0	3	1	3	1	4	0	5	5	4	0	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:4389751G>T	uc002fxt.2	+	11	1367	c.1323G>T	c.(1321-1323)CAG>CAT	p.Q441H	SPNS3_uc002fxu.2_Missense_Mutation_p.Q314H|SPNS3_uc002fxv.2_Missense_Mutation_p.Q92H|uc002fxw.1_5'Flank	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	441					lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						CCTATCTGCAGCGCTTCCGCA	0.662													8	45					2.62144e-13	6.12831e-13	1	0	T	4389751	T	T	4389751	3	4	154	1	0	0	0	0	1	0	0	0	15142	962	34	4	1365	4	SPNS3	17	4389751	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	828394	4389751	76805459	618	28465											
DVL2	1856	broad.mit.edu	37	chr17	7131012	7131012	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagatgtaatggtgctcatgGaggaggaacctggataggct	11	9	15	6	0	1	1	1	0	0	1	1	5	1	5	1	6	2	3	1	6	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:7131012G>A	uc002gez.1	-	11	1475	c.1193C>T	c.(1192-1194)TCC>TTC	p.S398F	DVL2_uc010vtr.1_Missense_Mutation_p.S392F	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	398					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						GGTGCTCATGGAGGAGGAACC	0.597													5	17					0	0	0	0	A	7131012	A	A	7131012	3	1	154	1	0	0	0	0	1	0	0	0	4858	1174	41	2	1037	2	DVL2	17	7131012	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2741261	7131012	74064198	619	28466											
TP53	7157	broad.mit.edu	37	chr17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccaggacaggcacaaacacGcacctcaaagctgttccgtc	12	5	8	16	2	1	0	1	0	0	0	3	1	2	1	3	2	2	4	3	2	2	1	rs121913343		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	18					0	0	0	0	A	7577121	A	A	7577121	3	1	154	1	0	0	0	0	1	0	0	0	16448	1087	38	1	469	1	TP53	17	7577121	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	446109	7577121	73618089	620	28467											
WDR16	146845	broad.mit.edu	37	chr17	9536276	9536276	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtatgtcattaacaatgctCacaggatcggcgtcaccgcc	10	10	9	12	3	3	0	3	0	0	0	4	1	3	1	2	2	2	2	2	2	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:9536276C>G	uc002gly.2	+	10	1315	c.1246C>G	c.(1246-1248)CAC>GAC	p.H416D	WDR16_uc002glz.2_Missense_Mutation_p.H348D|WDR16_uc010coc.2_Missense_Mutation_p.H426D	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	416	WD 7.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TAACAATGCTCACAGGATCGG	0.517													9	54					0	0	0	0	G	9536276	G	G	9536276	3	3	154	1	0	0	0	0	1	0	0	0	17344	826	29	2	1284	2	WDR16	17	9536276	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1959155	9536276	71658934	621	28468											
MYH1	4619	broad.mit.edu	37	chr17	10406202	10406202	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagcaatggtttcatccagAcccgccatctcttctgtgag	8	13	8	12	1	3	2	1	1	2	1	5	2	4	2	3	1	1	2	3	1	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:10406202A>G	uc002gmo.2	-	24	3058	c.2964T>C	c.(2962-2964)GGT>GGC	p.G988G	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	988	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TTTCATCCAGACCCGCCATCT	0.507													30	148					0	0	0	0	G	10406202	G	G	10406202	2	3	154	1	0	0	0	0	0	0	0	1	10082	262	10	5		5	MYH1	17	10406202	Silent	SNP	A	TCGA-CR-7388-01A-11D-2012-08	869926	10406202	70789008	622	28469											
MYOCD	93649	broad.mit.edu	37	chr17	12666489	12666489	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctgtcctcaccaagccctCggcttcctttgaacaagcct	7	11	7	16	1	1	1	1	1	0	0	4	1	3	1	5	1	4	2	5	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:12666489C>T	uc002gnn.2	+	13	2644	c.2345C>T	c.(2344-2346)TCG>TTG	p.S782L	MYOCD_uc002gno.2_Missense_Mutation_p.S830L|MYOCD_uc002gnq.2_Missense_Mutation_p.S506L	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	782					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ACCAAGCCCTCGGCTTCCTTT	0.498													5	89					0	0	0	0	T	12666489	T	T	12666489	3	4	154	1	0	0	0	0	1	0	0	0	10140	893	31	1	2555	1	MYOCD	17	12666489	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2260287	12666489	68528721	623	28470											
MYOCD	93649	broad.mit.edu	37	chr17	12666815	12666815	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aatctccctgggaaaccatgGagtggctggacctcactccg	9	8	11	13	1	2	0	1	0	1	0	4	3	3	3	4	4	1	1	4	4	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:12666815G>C	uc002gnn.2	+	13	2970	c.2671G>C	c.(2671-2673)GAG>CAG	p.E891Q	MYOCD_uc002gno.2_Missense_Mutation_p.E939Q|MYOCD_uc002gnq.2_Missense_Mutation_p.E615Q	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	891					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GGAAACCATGGAGTGGCTGGA	0.552													9	40					0	0	0	0	C	12666815	C	C	12666815	3	2	154	1	0	0	0	0	1	0	0	0	10140	1175	41	2	2881	2	MYOCD	17	12666815	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	326	12666815	68528395	624	28471											
KIAA0100	9703	broad.mit.edu	37	chr17	26961727	26961727	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaagtaagcagtgcccggcGcatgggtgtgttgccataga	9	8	14	10	2	0	1	0	0	0	1	0	1	0	1	3	2	3	4	3	2	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:26961727G>A	uc002hbu.2	-	16	2977	c.2878C>T	c.(2878-2880)CGC>TGC	p.R960C		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	960						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGTGCCCGGCGCATGGGTGTG	0.527													7	109					0	0	0	0	A	26961727	A	A	26961727	3	1	154	1	0	0	0	0	1	0	0	0	8193	1087	38	1	3925	1	KIAA0100	17	26961727	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	14294912	26961727	54233483	625	28472											
TAOK1	57551	broad.mit.edu	37	chr17	27829692	27829692	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaagtatctcgtcacaaatCacactatcgtaatcgagaac	15	9	5	12	3	3	1	2	0	1	1	6	2	3	1	1	0	1	2	1	0	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:27829692C>G	uc002hdz.1	+	13	1483	c.1289C>G	c.(1288-1290)TCA>TGA	p.S430*	TAOK1_uc010wbe.1_Nonsense_Mutation_p.S430*|TAOK1_uc010wbf.1_Nonsense_Mutation_p.S430*|TAOK1_uc002heb.1_Nonsense_Mutation_p.S256*	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	430					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			CGTCACAAATCACACTATCGT	0.393													7	41					0	0	0	0	G	27829692	G	G	27829692	4	3	154	1	0	0	0	0	0	1	0	0	15613	838	29	2	1335	2	TAOK1	17	27829692	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	867965	27829692	53365518	626	28473											
LRRC37B	114659	broad.mit.edu	37	chr17	30374901	30374901	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctcagacagcagtggcatCaacttgtcaggctttggggg	8	9	13	11	0	3	1	3	0	0	1	3	1	3	1	1	4	2	3	1	4	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:30374901C>G	uc002hgu.2	+	9	2375	c.2364C>G	c.(2362-2364)ATC>ATG	p.I788M	LRRC37B_uc010wbx.1_Missense_Mutation_p.I706M|LRRC37B_uc010csu.2_Missense_Mutation_p.I737M	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	788	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				GCAGTGGCATCAACTTGTCAG	0.507													25	309					0	0	0	0	G	30374901	G	G	30374901	3	3	154	1	0	0	0	0	1	0	0	0	9044	816	29	2	2398	2	LRRC37B	17	30374901	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2545209	30374901	50820309	627	28474											
SLFN12	55106	broad.mit.edu	37	chr17	33749704	33749704	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtggtaatccgcagaccaGaggtgttcaagctccatgac	11	8	12	10	1	1	3	1	1	0	2	3	3	3	3	3	3	1	4	3	3	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:33749704G>C	uc002hji.3	-	2	721	c.344C>G	c.(343-345)TCT>TGT	p.S115C	SLFN12_uc002hjj.3_Missense_Mutation_p.S115C|SLFN12_uc010cts.2_Missense_Mutation_p.S115C	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	115							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCGCAGACCAGAGGTGTTCAA	0.398													9	54					0	0	0	0	C	33749704	C	C	33749704	3	2	154	1	0	0	0	0	1	0	0	0	14798	942	33	2	1404	2	SLFN12	17	33749704	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3374803	33749704	47445506	628	28475											
MYO19	80179	broad.mit.edu	37	chr17	34871743	34871743	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagttcaggatcctctgttCtatcctctctgcaatcttgt	6	16	8	11	0	5	0	1	0	4	0	8	2	7	2	2	2	1	3	2	2	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:34871743C>G	uc010wcy.1	-	8	1497	c.505G>C	c.(505-507)GAA>CAA	p.E169Q	MYO19_uc002hmw.2_Missense_Mutation_p.E169Q|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA|MYO19_uc010wda.1_Missense_Mutation_p.E35Q|MYO19_uc002hmx.2_Missense_Mutation_p.E169Q	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	169	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ATCCTCTGTTCTATCCTCTCT	0.517													8	37					0	0	0	0	G	34871743	G	G	34871743	3	3	154	1	0	0	0	0	1	0	0	0	10120	922	32	2	2547	2	MYO19	17	34871743	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1122039	34871743	46323467	629	28476											
HNF1B	6928	broad.mit.edu	37	chr17	36093688	36093688	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttcttgttggtgggctcaGagcaggcatcatcggactgc	6	12	13	10	1	4	1	2	0	2	1	5	2	4	2	0	4	2	4	0	4	0	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:36093688G>C	uc002hok.3	-	3	892	c.671C>G	c.(670-672)TCT>TGT	p.S224C	HNF1B_uc010wdi.1_Missense_Mutation_p.S198C|HNF1B_uc010cve.1_Missense_Mutation_p.S32C	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	224					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GGTGGGCTCAGAGCAGGCATC	0.552									Hereditary_Prostate_Cancer				15	56					0	0	0	0	C	36093688	C	C	36093688	3	2	154	1	0	0	0	0	1	0	0	0	7291	942	33	2	1030	2	HNF1B	17	36093688	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1221945	36093688	45101522	630	28477											
GPR179	440435	broad.mit.edu	37	chr17	36484183	36484183	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggacaagccacctcccactCtggggttggcttctgtggct	5	10	13	13	0	2	0	0	0	2	0	3	1	3	1	3	5	1	3	3	5	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:36484183C>G	uc002hpz.2	-	11	5290	c.5269G>C	c.(5269-5271)GAG>CAG	p.E1757Q		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1757	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				ACCTCCCACTCTGGGGTTGGC	0.547													5	50					0	0	0	0	G	36484183	G	G	36484183	3	3	154	1	0	0	0	0	1	0	0	0	6712	922	32	2	1838	2	GPR179	17	36484183	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	390495	36484183	44711027	631	28478			3	45		5	5	1094	C		3.087002e-08
GPR179	440435	broad.mit.edu	37	chr17	36484226	36484226	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctggagcagtaacagctctCtccctgggtccaagatctgc	8	10	10	13	0	3	1	0	0	3	1	6	2	5	2	2	2	4	3	2	2	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:36484226C>G	uc002hpz.2	-	11	5247	c.5226G>C	c.(5224-5226)GAG>GAC	p.E1742D		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1742	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TAACAGCTCTCTCCCTGGGTC	0.577													5	52					0	0	0	0	G	36484226	G	G	36484226	3	3	154	1	0	0	0	0	1	0	0	0	6712	912	32	2	1881	2	GPR179	17	36484226	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	43	36484226	44710984	632	28479			3	45		5	5	1094	C		3.087002e-08
GPR179	440435	broad.mit.edu	37	chr17	36484372	36484372	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccagcagtcaagttttcctCcacatccaaagggcaaatgt	12	9	7	13	0	1	0	1	0	0	0	4	0	4	0	4	1	1	3	4	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:36484372C>A	uc002hpz.2	-	11	5101	c.5080G>T	c.(5080-5082)GAG>TAG	p.E1694*		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1694	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AAGTTTTCCTCCACATCCAAA	0.557													7	110					0.00307968	0.00575353	1	0	A	36484372	A	A	36484372	4	1	154	1	0	0	0	0	0	1	0	0	6712	864	30	2	2027	2	GPR179	17	36484372	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	146	36484372	44710838	633	28480			3	45		5	5	1094	C		3.087002e-08
GPR179	440435	broad.mit.edu	37	chr17	36484653	36484653	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtccattcctctcttgttCtttcatttacctcccaggga	6	17	5	13	0	3	0	1	0	2	0	7	1	6	1	4	1	1	1	4	1	1	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:36484653C>G	uc002hpz.2	-	11	4820	c.4799G>C	c.(4798-4800)AGA>ACA	p.R1600T		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1600	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CTCTCTTGTTCTTTCATTTAC	0.493													10	183					0	0	0	0	G	36484653	G	G	36484653	3	3	154	1	0	0	0	0	1	0	0	0	6712	913	32	2	2308	2	GPR179	17	36484653	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	281	36484653	44710557	634	28481			3	45		5	5	1094	C		3.087002e-08
GPR179	440435	broad.mit.edu	37	chr17	36485276	36485276	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actgcctcttgggctggtttCccatcctcgcctccttcact	3	14	7	17	1	2	0	1	0	1	0	6	0	5	0	5	2	1	2	5	2	0	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:36485276C>A	uc002hpz.2	-	11	4197	c.4176G>T	c.(4174-4176)GGG>GGT	p.G1392G		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1392	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GGGCTGGTTTCCCATCCTCGC	0.557													8	132					1.12685e-05	2.25627e-05	1	0	A	36485276	A	A	36485276	2	1	154	1	0	0	0	0	0	0	0	1	6712	842	30	2		2	GPR179	17	36485276	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	623	36485276	44709934	635	28482			3	45		5	5	1094	C		3.087002e-08
KCNH4	23415	broad.mit.edu	37	chr17	40315263	40315263	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tacctgtagggggcgcctggGagcggggccttggcagttca	5	8	18	10	2	1	0	1	0	0	0	1	1	1	1	3	6	2	3	3	6	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:40315263G>A	uc002hzb.2	-	14	2900	c.2567C>T	c.(2566-2568)TCC>TTC	p.S856F		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	856	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGGCGCCTGGGAGCGGGGCCT	0.517													11	46					0	0	0	0	A	40315263	A	A	40315263	3	1	154	1	0	0	0	0	1	0	0	0	8073	1174	41	2	498	2	KCNH4	17	40315263	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3829987	40315263	40879947	636	28483											
EZH1	2145	broad.mit.edu	37	chr17	40865279	40865279	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccctgtcactgtctccttcTttagtctcagccacagcaga	7	13	6	15	0	4	1	2	0	3	1	7	1	5	1	3	0	2	1	3	0	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:40865279T>C	uc002iaz.2	-	11	1297	c.1152A>G	c.(1150-1152)AAA>AAG	p.K384K	EZH1_uc002iba.2_Silent_p.K375K|EZH1_uc010wgt.1_Silent_p.K314K|EZH1_uc010wgu.1_Silent_p.K390K|EZH1_uc010wgv.1_Silent_p.K344K|EZH1_uc010wgw.1_Silent_p.K245K|EZH1_uc010cyp.2_Silent_p.K285K|EZH1_uc010cyq.2_Silent_p.K301K|EZH1_uc010cys.2_Silent_p.K335K|EZH1_uc010cyo.1_Silent_p.K47K|EZH1_uc010cyr.1_Silent_p.K36K	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	384					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		TGTCTCCTTCTTTAGTCTCAG	0.527													27	56					0	0	0	0	C	40865279	C	C	40865279	2	2	154	1	0	0	0	0	0	0	0	1	5358	1606	56	5		5	EZH1	17	40865279	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	550016	40865279	40329931	637	28484											
RPRML	388394	broad.mit.edu	37	chr17	45056164	45056164	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagcacgcagagcacggcGatctgcgccacccgcgacac	10	2	12	17	6	1	1	0	0	1	1	1	4	1	1	2	1	3	3	2	1	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:45056164G>T	uc002ilb.2	-	1	451	c.210C>A	c.(208-210)ATC>ATA	p.I70I	GOSR2_uc010wkh.1_Intron	NM_203400	NP_981945	Q8N4K4	RPRML_HUMAN	reprimo-like	70	Helical; (Potential).					integral to membrane					0						AGAGCACGGCGATCTGCGCCA	0.687													30	33					1.57351e-24	3.89611e-24	1	0	T	45056164	T	T	45056164	2	4	154	1	0	0	0	0	0	0	0	1	13684	1048	37	3		3	RPRML	17	45056164	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4190885	45056164	36139046	638	28485											
SPOP	8405	broad.mit.edu	37	chr17	47699430	47699430	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaatttcactaccttgatCtgttgatagaaaaacaggaa	16	11	8	6	0	2	4	1	2	1	2	2	6	2	5	1	1	2	1	1	1	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:47699430C>G	uc010dbk.2	-	4	711	c.79_splice	c.e4-1	p.I27_splice	SPOP_uc002ipb.2_Splice_Site_p.I27_splice|SPOP_uc002ipc.2_Splice_Site_p.I27_splice|SPOP_uc002ipd.2_Splice_Site_p.I27_splice|SPOP_uc002ipe.2_Splice_Site_p.I27_splice|SPOP_uc002ipf.2_Splice_Site_p.I27_splice|SPOP_uc002ipg.2_Splice_Site_p.I27_splice	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein						mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						CTACCTTGATCTGTTGATAGA	0.398										Prostate(2;0.17)			13	19					0	0	0	0	G	47699430	G	G	47699430	5	3	154	1	0	0	0	0	0	0	1	0	15150	927	32	2	1078	2	SPOP	17	47699430	Splice_Site	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2643266	47699430	33495780	639	28486											
C17orf71	55181	broad.mit.edu	37	chr17	57288086	57288086	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctttgatatcacttatgatcGagtattcagagccctggatg	10	14	9	8	1	2	3	2	2	0	1	3	5	2	4	1	1	1	1	1	1	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:57288086G>C	uc002ixi.2	+	1	716	c.674G>C	c.(673-675)CGA>CCA	p.R225P		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	225					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					ACTTATGATCGAGTATTCAGA	0.473													31	37					0	0	0	0	C	57288086	C	C	57288086	3	2	154	1	0	0	0	0	1	0	0	0	1885	1058	37	3	676	3	C17orf71	17	57288086	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	9588656	57288086	23907124	640	28487											
TUBD1	51174	broad.mit.edu	37	chr17	57955478	57955478	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatacctagtggatttcgtCtgtagtgaaatgagctttct	11	15	9	6	1	2	2	0	2	2	0	3	3	2	3	1	1	2	2	1	1	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:57955478C>T	uc002ixw.1	-	5	1033	c.755G>A	c.(754-756)AGA>AAA	p.R252K	TUBD1_uc010ddf.1_Missense_Mutation_p.R252K|TUBD1_uc010ddg.1_Missense_Mutation_p.R217K|TUBD1_uc010ddh.1_Missense_Mutation_p.R133K|TUBD1_uc010wok.1_Missense_Mutation_p.R252K|TUBD1_uc002ixx.1_Missense_Mutation_p.R252K|TUBD1_uc010wol.1_Missense_Mutation_p.R36K|TUBD1_uc010ddi.1_Intron	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	252					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			TGGATTTCGTCTGTAGTGAAA	0.408													6	27					0	0	0	0	T	57955478	T	T	57955478	3	4	154	1	0	0	0	0	1	0	0	0	16830	913	32	2	626	2	TUBD1	17	57955478	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	667392	57955478	23239732	641	28488											
CASKIN2	57513	broad.mit.edu	37	chr17	73498346	73498346	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgagatgggggcgtcccctCagggcctggctcctcctcct	3	8	13	17	2	1	1	1	0	0	1	5	2	5	1	7	4	0	1	7	4	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:73498346C>G	uc002joc.2	-	18	3359	c.2809G>C	c.(2809-2811)GAG>CAG	p.E937Q	CASKIN2_uc010wsc.1_Missense_Mutation_p.E855Q	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	937	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGCGTCCCCTCAGGGCCTGGC	0.701													6	18					0	0	0	0	G	73498346	G	G	73498346	3	3	154	1	0	0	0	0	1	0	0	0	2679	835	29	2	811	2	CASKIN2	17	73498346	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	15542868	73498346	7696864	642	28489											
NARF	26502	broad.mit.edu	37	chr17	80439061	80439061	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctgctttgcatggctcccGgggcgctgactgcgtgttaa	4	11	13	13	3	0	1	0	1	0	0	1	1	1	1	2	3	3	5	2	3	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr17:80439061G>A	uc002kfg.3	+	7	883	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	NARF_uc002kff.3_Missense_Mutation_p.R189Q|NARF_uc010wvo.1_Missense_Mutation_p.R203Q|NARF_uc010wvp.1_Missense_Mutation_p.R120Q|NARF_uc010dit.2_Missense_Mutation_p.R248Q|NARF_uc002kfj.3_Missense_Mutation_p.R200Q|NARF_uc002kfi.3_RNA|NARF_uc002kfh.3_Missense_Mutation_p.R294Q|NARF_uc002kfk.2_RNA	NM_012336	NP_036468	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor isoform a	248						lamin filament	lamin binding			skin(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			CATGGCTCCCGGGGCGCTGAC	0.587													19	87					0	0	0	0	A	80439061	A	A	80439061	3	1	154	1	0	0	0	0	1	0	0	0	10220	1116	39	1	769	1	NARF	17	80439061	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	6940715	80439061	756149	643	28490											
DLGAP1	9229	broad.mit.edu	37	chr18	3880032	3880032	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgagtcgcaggtgacccCgtggtgatggctgcggctgc	4	7	18	12	4	0	2	0	2	0	0	1	3	0	2	3	5	2	3	3	5	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:3880032C>G	uc002kmf.2	-	1	104	c.37G>C	c.(37-39)GGG>CGG	p.G13R	DLGAP1_uc010wyz.1_Missense_Mutation_p.G13R|DLGAP1_uc002kmk.2_Missense_Mutation_p.G13R|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	13					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CAGGTGACCCCGTGGTGATGG	0.662													11	25					0	0	0	0	G	3880032	G	G	3880032	3	3	154	1	0	0	0	0	1	0	0	0	4581	652	23	3	2991	3	DLGAP1	18	3880032	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08		3880032	74197216	644	28491											
EPB41L3	23136	broad.mit.edu	37	chr18	5397176	5397176	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggacagctttagcgacctCctcccctccttcctctttag	6	12	6	17	1	1	0	0	0	1	0	5	2	5	1	6	1	2	1	6	1	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:5397176C>A	uc002kmt.1	-	18	2808	c.2722G>T	c.(2722-2724)GAG>TAG	p.E908*	EPB41L3_uc010wzh.1_Nonsense_Mutation_p.E739*|EPB41L3_uc002kmu.1_Nonsense_Mutation_p.E686*|EPB41L3_uc010dkq.1_Nonsense_Mutation_p.E577*|EPB41L3_uc002kms.1_Nonsense_Mutation_p.E143*|EPB41L3_uc010wze.1_Nonsense_Mutation_p.E213*|EPB41L3_uc010wzf.1_Nonsense_Mutation_p.E205*|EPB41L3_uc010wzg.1_Nonsense_Mutation_p.E180*|EPB41L3_uc010dkr.2_Nonsense_Mutation_p.E300*	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	908	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TTAGCGACCTCCTCCCCTCCT	0.577													24	124					6.44725e-10	1.4329e-09	1	0	A	5397176	A	A	5397176	4	1	154	1	0	0	0	0	0	1	0	0	5178	864	30	2	561	2	EPB41L3	18	5397176	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1517144	5397176	72680072	645	28492											
PTPRM	5797	broad.mit.edu	37	chr18	7955122	7955122	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggtttgtctttcagaacCacccgttcctattgccccac	6	14	6	15	1	3	1	1	0	2	1	4	1	4	1	5	1	2	2	5	1	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:7955122C>A	uc002knn.3	+	7	1345	c.842C>A	c.(841-843)CCA>CAA	p.P281Q	PTPRM_uc010dkv.2_Missense_Mutation_p.P281Q|PTPRM_uc010wzl.1_Missense_Mutation_p.P68Q	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	281	Fibronectin type-III 1.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CTTTCAGAACCACCCGTTCCT	0.448													10	56					3.86212e-05	7.65457e-05	1	0	A	7955122	A	A	7955122	3	1	154	1	0	0	0	0	1	0	0	0	12871	594	21	4	868	4	PTPRM	18	7955122	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2557946	7955122	70122126	646	28493											
ANKRD12	23253	broad.mit.edu	37	chr18	9258619	9258619	+	Frame_Shift_Del	DEL	G	-	-																															tcctcaaattcaccatccacGgaaaaggaaagtgtcacgtg																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:9258619delG	uc002knv.2	+	9	5611	c.5354delG	c.(5353-5355)CGGfs	p.R1785fs	ANKRD12_uc002knw.2_Frame_Shift_Del_p.R1762fs|ANKRD12_uc002knx.2_Frame_Shift_Del_p.R1762fs|ANKRD12_uc010dkx.1_Frame_Shift_Del_p.R1492fs	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1785						nucleus				ovary(2)|central_nervous_system(1)	3						CACCATCCACGGAAAAGGAAA	0.423													---	---	---								-	9258619	-	-	9258619	7	5	154	1	0	1	0	1	0	0	0	0	640	1116	39	0	5384	0	ANKRD12	18	9258619	Frame_Shift_Del	DEL	G	TCGA-CR-7388-01A-11D-2012-08	1303497	9258619	68818629	647	28494											
MC2R	4158	broad.mit.edu	37	chr18	13884801	13884801	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcagaatgtcatcaagagGacatgaagcacaaagggggc	15	4	15	7	0	2	3	2	1	0	2	2	4	2	4	0	4	1	2	0	4	4	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:13884801G>T	uc002ksp.1	-	2	894	c.717C>A	c.(715-717)GTC>GTA	p.V239V		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	239	Helical; Name=6; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	TCATCAAGAGGACATGAAGCA	0.542													7	49					8.12818e-05	0.000159302	1	0	T	13884801	T	T	13884801	2	4	154	1	0	0	0	0	0	0	0	1	9417	1161	41	2		2	MC2R	18	13884801	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4626182	13884801	64192447	648	28495											
ASXL3	80816	broad.mit.edu	37	chr18	31323161	31323161	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctttgcaaagcatcaagctCgagcccatctcttccagacc	10	10	6	15	1	3	1	1	0	2	1	6	2	4	1	3	0	4	3	3	0	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:31323161C>T	uc010dmg.1	+	12	3404	c.3349C>T	c.(3349-3351)CGA>TGA	p.R1117*	ASXL3_uc002kxq.2_Nonsense_Mutation_p.R824*	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1117					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GCATCAAGCTCGAGCCCATCT	0.527													7	36					0	0	0	0	T	31323161	T	T	31323161	4	4	154	1	0	0	0	0	0	1	0	0	1070	876	31	1	3395	1	ASXL3	18	31323161	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	17438360	31323161	46754087	649	28496											
ASXL3	80816	broad.mit.edu	37	chr18	31326042	31326042	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acagtccacgggcatatgtaGcaatataaaatcggaacctc	15	8	8	10	2	0	0	0	0	0	0	3	1	1	1	2	2	2	3	2	2	7	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:31326042G>T	uc010dmg.1	+	12	6285	c.6230G>T	c.(6229-6231)AGC>ATC	p.S2077I	ASXL3_uc002kxq.2_Missense_Mutation_p.S1784I	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2077					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GGCATATGTAGCAATATAAAA	0.413													13	77					2.32078e-09	5.10631e-09	1	0	T	31326042	T	T	31326042	3	4	154	1	0	0	0	0	1	0	0	0	1070	971	34	4	6276	4	ASXL3	18	31326042	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2881	31326042	46751206	650	28497											
FHOD3	80206	broad.mit.edu	37	chr18	34261476	34261476	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcagagagagagaggcggcGgcaggagagagaagaaaggt	16	1	20	4	2	0	6	0	0	0	6	0	10	0	6	0	5	1	2	0	5	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:34261476G>T	uc002kzt.1	+	12	1485	c.1388G>T	c.(1387-1389)CGG>CTG	p.R463L	FHOD3_uc002kzr.1_Missense_Mutation_p.R463L|FHOD3_uc002kzs.1_Missense_Mutation_p.R463L|FHOD3_uc010dmz.1_Missense_Mutation_p.R178L	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	463	Potential.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				GAGAGGCGGCGGCAGGAGAGA	0.433													11	54					0.000673444	0.00128547	1	0	T	34261476	T	T	34261476	3	4	154	1	0	0	0	0	1	0	0	0	5915	1116	39	3	1434	3	FHOD3	18	34261476	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2935434	34261476	43815772	651	28498											
NEDD4L	23327	broad.mit.edu	37	chr18	56034991	56034991	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaaagggacaactacaccCttcagatcaaccctaattca	16	8	4	13	0	4	1	4	0	0	1	4	2	4	2	2	1	3	0	2	1	6	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:56034991C>G	uc002lgy.2	+	22	2351	c.2077C>G	c.(2077-2079)CTT>GTT	p.L693V	NEDD4L_uc002lgz.2_Missense_Mutation_p.L629V|NEDD4L_uc002lgx.2_Missense_Mutation_p.L673V|NEDD4L_uc010xee.1_Missense_Mutation_p.L572V|NEDD4L_uc002lhc.2_Missense_Mutation_p.L685V|NEDD4L_uc002lhd.2_Missense_Mutation_p.L572V|NEDD4L_uc002lhb.2_Missense_Mutation_p.L552V|NEDD4L_uc002lhe.2_Missense_Mutation_p.L665V|NEDD4L_uc002lhf.2_Missense_Mutation_p.L552V|NEDD4L_uc002lhg.2_Missense_Mutation_p.L572V|NEDD4L_uc002lhh.2_Missense_Mutation_p.L468V|NEDD4L_uc010dpn.2_Intron	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	693	HECT.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						CAACTACACCCTTCAGATCAA	0.413													9	43					0	0	0	0	G	56034991	G	G	56034991	3	3	154	1	0	0	0	0	1	0	0	0	10365	681	24	4	2191	4	NEDD4L	18	56034991	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	21773515	56034991	22042257	652	28499											
ALPK2	115701	broad.mit.edu	37	chr18	56202141	56202141	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgataatgatgtttcgagttTgggcatctttttaagaaagg	11	16	11	3	1	1	3	0	2	1	1	2	4	1	3	0	2	0	3	0	2	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:56202141T>A	uc002lhj.3	-	5	5492	c.5278A>T	c.(5278-5280)AAA>TAA	p.K1760*	ALPK2_uc002lhk.1_Nonsense_Mutation_p.K1091*	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1760							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GTTTCGAGTTTGGGCATCTTT	0.403													17	118					0	0	0	0	A	56202141	A	A	56202141	4	1	154	1	0	0	0	0	0	1	0	0	545	1821	63	5	1270	5	ALPK2	18	56202141	Nonsense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	167150	56202141	21875107	653	28500											
CDH19	28513	broad.mit.edu	37	chr18	64172405	64172405	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcctcagctctgctatatCaaaggcctctgtatcttctt	8	15	5	13	0	6	0	2	0	4	0	7	0	7	0	2	1	2	3	2	1	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr18:64172405C>G	uc002lkc.1	-	12	2101	c.1963G>C	c.(1963-1965)GAT>CAT	p.D655H	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	655	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TCTGCTATATCAAAGGCCTCT	0.433													43	167					0	0	0	0	G	64172405	G	G	64172405	3	3	154	1	0	0	0	0	1	0	0	0	3119	826	29	2	359	2	CDH19	18	64172405	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	7970264	64172405	13904843	654	28501											
LMNB2	84823	broad.mit.edu	37	chr19	2435054	2435054	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagccgcacttgctcgtcgTgctggctccgcagctcctcc	4	9	11	17	4	0	1	0	0	0	1	5	1	3	1	4	1	4	6	4	1	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:2435054T>C	uc002lvy.2	-	5	827	c.740A>G	c.(739-741)CAC>CGC	p.H247R	LMNB2_uc002lwa.1_Missense_Mutation_p.H267R	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	247	Rod.|Coil 2.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGCTCGTCGTGCTGGCTCCG	0.532													10	45					0	0	0	0	C	2435054	C	C	2435054	3	2	154	1	0	0	0	0	1	0	0	0	8892	1696	59	5	1094	5	LMNB2	19	2435054	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08		2435054	56693929	655	28502											
TLE6	79816	broad.mit.edu	37	chr19	2987363	2987363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catggtgacagagcaggcacCaggcctggtgagtaaacaac	13	5	13	10	0	0	3	0	2	0	1	0	3	0	3	2	4	3	3	2	4	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:2987363C>T	uc002lwu.2	+	7	582	c.182C>T	c.(181-183)CCA>CTA	p.P61L	TLE6_uc002lwt.2_Missense_Mutation_p.P184L|TLE6_uc010dtg.2_Intron|TLE6_uc002lwv.2_5'Flank	NM_024760	NP_079036	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 isoform 2	61					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGCAGGCACCAGGCCTGGTG	0.637													5	74					0	0	0	0	T	2987363	T	T	2987363	3	4	154	1	0	0	0	0	1	0	0	0	16008	594	21	4	577	4	TLE6	19	2987363	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	552309	2987363	56141620	656	28503											
LRG1	116844	broad.mit.edu	37	chr19	4538167	4538167	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tagggatgcccagagcccctCgggcacgctggccagtgagt	7	6	15	13	2	0	2	0	1	0	1	1	3	0	3	4	3	2	2	4	3	1	1	rs112633064		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:4538167C>G	uc002mau.2	-	2	840	c.829G>C	c.(829-831)GAG>CAG	p.E277Q	PLIN5_uc002mas.2_5'Flank|PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	277	LRR 8.					extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGAGCCCCTCGGGCACGCTG	0.642													11	104					0	0	0	0	G	4538167	G	G	4538167	3	3	154	1	0	0	0	0	1	0	0	0	8992	893	31	3	218	3	LRG1	19	4538167	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1550804	4538167	54590816	657	28504											
CRB3	92359	broad.mit.edu	37	chr19	6465616	6465616	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttcatccaccagctccagctCcgatggcaacctggtgagtt	8	10	9	14	1	1	1	1	1	0	0	4	2	4	1	5	2	3	4	5	2	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:6465616C>G	uc002mey.2	+	3	674	c.143C>G	c.(142-144)TCC>TGC	p.S48C	CRB3_uc002mez.2_Missense_Mutation_p.S48C|CRB3_uc002mfa.2_Missense_Mutation_p.S48C	NM_139161	NP_631900	Q9BUF7	CRUM3_HUMAN	crumbs 3 isoform a precursor	48	Extracellular (Potential).				protein localization in plasma membrane|tight junction assembly	apical plasma membrane|integral to membrane|tight junction	SH3 domain binding				0						AGCTCCAGCTCCGATGGCAAC	0.493													48	199					0	0	0	0	G	6465616	G	G	6465616	3	3	154	1	0	0	0	0	1	0	0	0	3865	855	30	2	149	2	CRB3	19	6465616	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1927449	6465616	52663367	658	28505											
C3	718	broad.mit.edu	37	chr19	6694461	6694461	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccttcttgatgagctccaaGgccccctgccgcttctctag	5	11	8	17	1	2	2	0	2	2	0	4	2	3	2	5	1	2	2	5	1	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:6694461G>T	uc002mfm.2	-	24	3197	c.3135C>A	c.(3133-3135)GCC>GCA	p.A1045A	C3_uc002mfl.2_5'Flank	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1045					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGAGCTCCAAGGCCCCCTGCC	0.597													12	53					6.40141e-05	0.000126162	1	0	T	6694461	T	T	6694461	2	4	154	1	0	0	0	0	0	0	0	1	2214	987	35	4		4	C3	19	6694461	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	228845	6694461	52434522	659	28506											
MCOLN1	57192	broad.mit.edu	37	chr19	7594574	7594574	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tactgcttctgtggctggatCgtgctggggccctatcatgt	4	14	13	10	1	2	0	1	0	1	0	3	1	2	1	1	4	3	3	1	4	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:7594574C>G	uc002mgo.2	+	11	1460	c.1335C>G	c.(1333-1335)ATC>ATG	p.I445M	MCOLN1_uc002mgp.2_Missense_Mutation_p.I410M	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	445	Helical; (Potential).				calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						GTGGCTGGATCGTGCTGGGGC	0.582													20	99					0	0	0	0	G	7594574	G	G	7594574	3	3	154	1	0	0	0	0	1	0	0	0	9448	874	31	3	1377	3	MCOLN1	19	7594574	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	900113	7594574	51534409	660	28507											
STXBP2	6813	broad.mit.edu	37	chr19	7705802	7705802	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagcctgccccgagcccctGttcagtgagctaggccgctc	5	7	11	18	2	1	1	1	1	0	0	2	2	1	1	7	1	4	3	7	1	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:7705802G>C	uc002mha.3	+	6	387	c.342G>C	c.(340-342)CTG>CTC	p.L114L	STXBP2_uc002mhb.3_Silent_p.L111L|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Silent_p.L125L|STXBP2_uc010dvk.2_Silent_p.L82L|STXBP2_uc002mhc.3_5'UTR|STXBP2_uc010dvl.1_Silent_p.L275L	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	114					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						CCGAGCCCCTGTTCAGTGAGC	0.657													6	81					0	0	0	0	C	7705802	C	C	7705802	2	2	154	1	0	0	0	0	0	0	0	1	15419	1364	48	4		4	STXBP2	19	7705802	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	111228	7705802	51423181	661	28508											
CD209	30835	broad.mit.edu	37	chr19	7810693	7810693	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctcacccactgcagccttCagccaggtcagctcctggta	8	8	9	16	0	3	0	3	0	0	0	4	0	4	0	4	2	5	4	4	2	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:7810693C>T	uc002mht.2	-	4	526	c.459G>A	c.(457-459)CTG>CTA	p.L153L	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Silent_p.L129L|CD209_uc002mhr.2_Silent_p.L129L|CD209_uc002mhs.2_Silent_p.L129L|CD209_uc002mhu.2_Silent_p.L153L|CD209_uc010dvq.2_Silent_p.L153L|CD209_uc002mhq.2_Silent_p.L153L|CD209_uc002mhv.2_Silent_p.L129L|CD209_uc002mhx.2_Silent_p.L109L|CD209_uc002mhw.2_Silent_p.L109L|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	153	Extracellular (Probable).|7 X approximate tandem repeats.|3.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						CTGCAGCCTTCAGCCAGGTCA	0.552													17	196					0	0	0	0	T	7810693	T	T	7810693	2	4	154	1	0	0	0	0	0	0	0	1	2999	813	29	2		2	CD209	19	7810693	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	104891	7810693	51318290	662	28509											
HNRNPM	4670	broad.mit.edu	37	chr19	8531162	8531162	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaactgaaggaagtatttaGtatggctggtgtggtggtcc	10	12	15	4	0	0	1	0	1	0	0	1	3	1	2	1	5	1	3	1	5	6	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:8531162G>A	uc010dwe.2	+	7	754	c.674G>A	c.(673-675)AGT>AAT	p.S225N	HNRNPM_uc010dwc.1_Missense_Mutation_p.S225N|HNRNPM_uc010xke.1_Missense_Mutation_p.S186N|HNRNPM_uc010dwd.2_Missense_Mutation_p.S186N|HNRNPM_uc002mka.2_Missense_Mutation_p.S105N	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	225	RRM 2.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						GAAGTATTTAGTATGGCTGGT	0.403													16	100					0	0	0	0	A	8531162	A	A	8531162	3	1	154	1	0	0	0	0	1	0	0	0	7310	1029	36	4	700	4	HNRNPM	19	8531162	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	720469	8531162	50597821	663	28510											
MUC16	94025	broad.mit.edu	37	chr19	9048498	9048498	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccactagaactagtgaccaGagaggtcaccactcctggta	12	8	9	12	0	1	3	1	1	0	2	3	4	3	3	4	2	1	1	4	2	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:9048498G>A	uc002mkp.2	-	5	33337	c.33133C>T	c.(33133-33135)CTG>TTG	p.L11045L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11047	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTAGTGACCAGAGAGGTCACC	0.493													18	75					0	0	0	0	A	9048498	A	A	9048498	2	1	154	1	0	0	0	0	0	0	0	1	10026	933	33	2		2	MUC16	19	9048498	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	517336	9048498	50080485	664	28511											
MUC16	94025	broad.mit.edu	37	chr19	9068263	9068263	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgttctggagacctcagtagTagcagcagtgaatgctttgt	9	13	12	7	0	2	2	1	1	1	1	2	3	2	2	1	1	3	6	1	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:9068263T>A	uc002mkp.2	-	3	19387	c.19183A>T	c.(19183-19185)ACT>TCT	p.T6395S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6397	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACCTCAGTAGTAGCAGCAGTG	0.488													11	67					0	0	0	0	A	9068263	A	A	9068263	3	1	154	1	0	0	0	0	1	0	0	0	10026	1638	57	5	24668	5	MUC16	19	9068263	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	19765	9068263	50060720	665	28512											
MUC16	94025	broad.mit.edu	37	chr19	9083129	9083129	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtatccaaacttgggacctCagaaaactcaaatgtcaagg	16	8	8	9	0	3	1	3	0	0	1	4	2	4	2	2	2	2	1	2	2	6	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:9083129C>T	uc002mkp.2	-	1	8890	c.8686G>A	c.(8686-8688)GAG>AAG	p.E2896K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2897	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTTGGGACCTCAGAAAACTCA	0.507													5	25					0	0	0	0	T	9083129	T	T	9083129	3	4	154	1	0	0	0	0	1	0	0	0	10026	835	29	2	35173	2	MUC16	19	9083129	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	14866	9083129	50045854	666	28513											
OR7D2	162998	broad.mit.edu	37	chr19	9297146	9297146	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccataaggaagatgtcctCatctgggggaaaacaaaaag	17	7	10	7	0	2	1	1	0	1	1	4	3	4	3	2	3	1	0	2	3	6	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:9297146C>G	uc002mkz.1	+	1	877	c.689C>G	c.(688-690)TCA>TGA	p.S230*		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	230	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						AAGATGTCCTCATCTGGGGGA	0.463													8	58					0	0	0	0	G	9297146	G	G	9297146	4	3	154	1	0	0	0	0	0	1	0	0	11273	838	29	2	691	2	OR7D2	19	9297146	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	214017	9297146	49831837	667	28514											
DNM2	1785	broad.mit.edu	37	chr19	10893674	10893674	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgcagccagaaggatattGagggcaagaaggacatccgt	14	5	13	9	2	0	3	0	1	0	2	1	5	1	5	3	3	1	2	3	3	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:10893674G>C	uc002mps.1	+	6	891	c.727G>C	c.(727-729)GAG>CAG	p.E243Q	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Missense_Mutation_p.E243Q|DNM2_uc002mpv.1_Missense_Mutation_p.E243Q|DNM2_uc002mpu.1_Missense_Mutation_p.E243Q|DNM2_uc010dxl.1_Missense_Mutation_p.E243Q|DNM2_uc002mpw.2_5'UTR	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	243					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			GAAGGATATTGAGGGCAAGAA	0.622													6	57					0	0	0	0	C	10893674	C	C	10893674	3	2	154	1	0	0	0	0	1	0	0	0	4694	1291	45	2	749	2	DNM2	19	10893674	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1596528	10893674	48235309	668	28515											
ZNF563	147837	broad.mit.edu	37	chr19	12430511	12430511	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaatgacccattatgacttCttcacactcagcgctttgac	11	13	5	12	1	3	3	2	3	1	0	3	3	3	3	1	0	1	1	1	0	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:12430511C>G	uc002mtp.2	-	4	566	c.328G>C	c.(328-330)GAA>CAA	p.E110Q	ZNF563_uc002mtq.2_Missense_Mutation_p.E110Q	NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	110	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTATGACTTCTTCACACTCA	0.418													13	145					0	0	0	0	G	12430511	G	G	12430511	3	3	154	1	0	0	0	0	1	0	0	0	18061	922	32	2	1106	2	ZNF563	19	12430511	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1536837	12430511	46698472	669	28516											
ZNF563	147837	broad.mit.edu	37	chr19	12432114	12432114	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcctaggatttttgtactGatcttcagtattctgttctt	6	21	6	8	0	5	1	1	1	4	0	6	2	5	2	1	1	1	3	1	1	3	9			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:12432114G>C	uc002mtp.2	-	3	401	c.163C>G	c.(163-165)CAG>GAG	p.Q55E	ZNF563_uc002mtq.2_Missense_Mutation_p.Q55E	NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	55	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTTTTGTACTGATCTTCAGTA	0.299													3	27					0	0	0	0	C	12432114	C	C	12432114	3	2	154	1	0	0	0	0	1	0	0	0	18061	1299	45	2	1275	2	ZNF563	19	12432114	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1603	12432114	46696869	670	28517											
ZNF443	10224	broad.mit.edu	37	chr19	12542690	12542690	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctttcacaaggacctactCcaggaagagtgttcttggtc	9	12	10	10	0	2	1	1	0	1	1	4	3	3	3	2	3	2	2	2	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:12542690C>A	uc002mtu.2	-	4	494	c.296G>T	c.(295-297)GGA>GTA	p.G99V		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	99					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						AGGACCTACTCCAGGAAGAGT	0.413													9	51					5.68852e-11	1.28211e-10	1	0	A	12542690	A	A	12542690	3	1	154	1	0	0	0	0	1	0	0	0	17983	855	30	2	1723	2	ZNF443	19	12542690	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	110576	12542690	46586293	671	28518											
RNASEH2A	10535	broad.mit.edu	37	chr19	12924254	12924254	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accgatatttcctggaacgcGgcctggagtcagcaaccagc	10	7	11	13	3	1	0	1	0	0	0	2	3	2	2	4	3	4	1	4	3	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:12924254G>T	uc002mvg.1	+	8	934	c.874G>T	c.(874-876)GGC>TGC	p.G292C	RNASEH2A_uc002mvf.1_Missense_Mutation_p.G210C	NM_006397	NP_006388	O75792	RNH2A_HUMAN	ribonuclease H2, large subunit	292					DNA replication|RNA catabolic process	nucleus|ribonuclease H2 complex	metal ion binding|ribonuclease H activity|RNA binding			breast(2)|central_nervous_system(1)	3						CCTGGAACGCGGCCTGGAGTC	0.542													7	48					0.00198382	0.003734	1	0	T	12924254	T	T	12924254	3	4	154	1	0	0	0	0	1	0	0	0	13477	1116	39	3	904	3	RNASEH2A	19	12924254	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	381564	12924254	46204729	672	28519											
LPHN1	22859	broad.mit.edu	37	chr19	14261849	14261850	+	Frame_Shift_Ins	INS	-	G	G																															cgcgaggtgtagtagatttcINSgggggggccggggggtgcgg																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:14261849_14261850insG	uc010xnn.1	-	24	4556_4557	c.4260_4261insC	c.(4258-4263)CCCGAAfs	p.P1420fs	LPHN1_uc010xno.1_Frame_Shift_Ins_p.P1415fs|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	1420_1421	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						TAGTAGATTTCGGGGGGGCCGG	0.733													---	---	---								G	14261850	G	G	14261849	7	5	154	1	0	1	1	0	0	0	0	0	8965	893	31	0	167	0	LPHN1	19	14261849	Frame_Shift_Ins	INS	-	TCGA-CR-7388-01A-11D-2012-08	1337595	14261849	44867134	673	28520											
CLEC17A	388512	broad.mit.edu	37	chr19	14710934	14710934	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accaagtcatgggatgaggcCcggatgttctgccaggagaa	11	7	14	9	1	2	2	1	1	1	1	2	5	2	4	3	4	1	1	3	4	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:14710934C>T	uc010dzn.1	+	12	911	c.834C>T	c.(832-834)GCC>GCT	p.A278A	CLEC17A_uc002mzh.1_Silent_p.A261A|CLEC17A_uc010xnt.1_RNA|CLEC17A_uc010xnu.1_Intron|CLEC17A_uc010dzo.1_Silent_p.A278A			Q6ZS10	CL17A_HUMAN	SubName: Full=CLEC17A protein;	278	C-type lectin.|Extracellular (Potential).					cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity				0						GGGATGAGGCCCGGATGTTCT	0.527													8	51					0	0	0	0	T	14710934	T	T	14710934	2	4	154	1	0	0	0	0	0	0	0	1	3516	610	22	4		4	CLEC17A	19	14710934	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	449085	14710934	44418049	674	28521											
PGLYRP2	114770	broad.mit.edu	37	chr19	15587077	15587077	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agggcaaatttatgaccctgCgcccttgcagccctgcctcc	7	9	9	16	1	0	1	0	1	0	0	1	1	1	1	5	1	4	2	5	1	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:15587077C>T	uc002nbf.3	-	2	537	c.404G>A	c.(403-405)CGC>CAC	p.R135H	PGLYRP2_uc002nbg.3_Missense_Mutation_p.R135H	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	135					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						TATGACCCTGCGCCCTTGCAG	0.597													13	67					0	0	0	0	T	15587077	T	T	15587077	3	4	154	1	0	0	0	0	1	0	0	0	11849	768	27	1	1342	1	PGLYRP2	19	15587077	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	876143	15587077	43541906	675	28522											
NCAN	1463	broad.mit.edu	37	chr19	19356187	19356187	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtggcgaggactgtgtggtGatggtggcgcatgaaagcgg	7	8	21	5	3	0	2	0	2	0	0	0	4	0	3	0	7	1	1	0	7	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:19356187G>A	uc002nlz.2	+	13	3657	c.3558G>A	c.(3556-3558)GTG>GTA	p.V1186V	NCAN_uc002nma.2_Intron	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1186	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			ACTGTGTGGTGATGGTGGCGC	0.577													13	53					0	0	0	0	A	19356187	A	A	19356187	2	1	154	1	0	0	0	0	0	0	0	1	10258	1277	45	2		2	NCAN	19	19356187	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3769110	19356187	39772796	676	28523											
ZNF43	7594	broad.mit.edu	37	chr19	21991840	21991840	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctctccagtatgaattctCttatgtttagtaagagttga	10	18	7	6	0	2	3	0	2	2	1	5	3	3	3	1	0	0	4	1	0	5	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:21991840C>T	uc002nqj.2	-	4	1129	c.999G>A	c.(997-999)AAG>AAA	p.K333K	ZNF43_uc010ecv.2_Silent_p.K327K|ZNF43_uc002nql.2_Silent_p.K327K|ZNF43_uc002nqm.2_Silent_p.K327K|ZNF43_uc002nqk.2_Silent_p.K263K	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	333	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TATGAATTCTCTTATGTTTAG	0.388													11	57					0	0	0	0	T	21991840	T	T	21991840	2	4	154	1	0	0	0	0	0	0	0	1	17970	912	32	2		2	ZNF43	19	21991840	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2635653	21991840	37137143	677	28524											
ZNF208	7757	broad.mit.edu	37	chr19	22155676	22155676	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacattcttcacatttgtaGggtttctctccagtatgaat	9	16	6	10	0	3	1	1	1	2	0	5	1	4	1	2	1	0	3	2	1	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:22155676G>C	uc002nqp.2	-	5	2009	c.1860C>G	c.(1858-1860)CCC>CCG	p.P620P	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CACATTTGTAGGGTTTCTCTC	0.373													16	77					0	0	0	0	C	22155676	C	C	22155676	2	2	154	1	0	0	0	0	0	0	0	1	17833	987	35	4		4	ZNF208	19	22155676	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	163836	22155676	36973307	678	28525											
ZNF99	7652	broad.mit.edu	37	chr19	22942301	22942301	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttccctgggtagttgtcCaacattggttaagtttatta	8	19	8	6	0	0	0	0	0	0	0	2	0	2	0	2	2	1	4	2	2	5	9			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:22942301C>G	uc010xrh.1	-	4	473	c.473G>C	c.(472-474)TGG>TCG	p.W158S		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GGTAGTTGTCCAACATTGGTT	0.303													7	59					0	0	0	0	G	22942301	G	G	22942301	3	3	154	1	0	0	0	0	1	0	0	0	18271	595	21	4	2655	4	ZNF99	19	22942301	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	786625	22942301	36186682	679	28526											
ZNF536	9745	broad.mit.edu	37	chr19	30936467	30936467	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggaggatgggctgcacgtGggcctggatgagcggcgtgg	6	6	22	7	3	0	1	0	1	0	0	0	5	0	4	1	7	2	2	1	7	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:30936467G>T	uc002nsu.1	+	2	2136	c.1998G>T	c.(1996-1998)GTG>GTT	p.V666V	ZNF536_uc010edd.1_Silent_p.V666V	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	666					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGCTGCACGTGGGCCTGGATG	0.701													13	43					0.00136819	0.0025947	1	0	T	30936467	T	T	30936467	2	4	154	1	0	0	0	0	0	0	0	1	18041	1335	47	4		4	ZNF536	19	30936467	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	7994166	30936467	28192516	680	28527											
SBSN	374897	broad.mit.edu	37	chr19	36018830	36018830	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtccagcagcgttgttgacCccatggccaagcttctctgc	6	11	10	14	1	1	1	0	1	1	0	3	1	2	1	4	1	4	4	4	1	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:36018830C>T	uc002oae.1	-	1	424	c.354G>A	c.(352-354)GGG>GGA	p.G118G	SBSN_uc002oad.1_Silent_p.G118G	NM_198538	NP_940940	Q6UWP8	SBSN_HUMAN	suprabasin isoform 2 precursor	118	Ala/Gly/His-rich.					extracellular region				ovary(1)	1	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CGTTGTTGACCCCATGGCCAA	0.572													10	154					0	0	0	0	T	36018830	T	T	36018830	2	4	154	1	0	0	0	0	0	0	0	1	13929	610	22	4		4	SBSN	19	36018830	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	5082363	36018830	23110153	681	28528											
TMEM149	79713	broad.mit.edu	37	chr19	36231339	36231339	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgggagtaggggtcacggctCcgccgccgcaggggctacat	6	5	17	13	5	1	0	1	0	0	0	2	1	2	1	3	6	1	4	3	6	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:36231339C>T	uc002obc.2	-	3	385	c.284G>A	c.(283-285)GGA>GAA	p.G95E	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Missense_Mutation_p.G95E|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Missense_Mutation_p.G175E	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	95	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGTCACGGCTCCGCCGCCGCA	0.687													8	28					0	0	0	0	T	36231339	T	T	36231339	3	4	154	1	0	0	0	0	1	0	0	0	16128	855	30	2	795	2	TMEM149	19	36231339	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	212509	36231339	22897644	682	28529											
ZNF585A	199704	broad.mit.edu	37	chr19	37643946	37643946	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaattcttcggtgtgcaatCaaatgggtcttctggatgaa	10	14	11	6	1	4	2	1	2	3	0	5	3	4	3	0	3	1	1	0	3	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:37643946C>A	uc002ofo.1	-	5	1086	c.855G>T	c.(853-855)TTG>TTT	p.L285F	ZNF585A_uc002ofm.1_Missense_Mutation_p.L230F|ZNF585A_uc002ofn.1_Missense_Mutation_p.L230F	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	285	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGTGTGCAATCAAATGGGTCT	0.433													45	175					2.13384e-23	5.25391e-23	1	0	A	37643946	A	A	37643946	3	1	154	1	0	0	0	0	1	0	0	0	18084	825	29	2	1458	2	ZNF585A	19	37643946	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1412607	37643946	21485037	683	28530											
SIPA1L3	23094	broad.mit.edu	37	chr19	38682885	38682885	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaactacaaatccaccatcGaggatgacctgaagaaactc	17	6	7	11	1	0	4	0	2	0	2	3	6	1	5	3	1	3	0	3	1	5	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:38682885G>A	uc002ohk.2	+	17	5040	c.4531G>A	c.(4531-4533)GAG>AAG	p.E1511K		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1511					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ATCCACCATCGAGGATGACCT	0.582													16	41					0	0	0	0	A	38682885	A	A	38682885	3	1	154	1	0	0	0	0	1	0	0	0	14396	1059	37	1	4589	1	SIPA1L3	19	38682885	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1038939	38682885	20446098	684	28531											
SIPA1L3	23094	broad.mit.edu	37	chr19	38692545	38692545	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctctgaacgacccggccctGagcccggacatcccgcctgc	6	6	10	19	4	1	2	0	2	1	0	3	4	2	3	5	2	3	0	5	2	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:38692545G>C	uc002ohk.2	+	20	5537	c.5028G>C	c.(5026-5028)CTG>CTC	p.L1676L		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1676					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ACCCGGCCCTGAGCCCGGACA	0.657													4	53					0	0	0	0	C	38692545	C	C	38692545	2	2	154	1	0	0	0	0	0	0	0	1	14396	1277	45	2		2	SIPA1L3	19	38692545	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	9660	38692545	20436438	685	28532											
RASGRP4	115727	broad.mit.edu	37	chr19	38903644	38903644	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtcgctcaaagtcctcctGagagattgttcctcggcctt	7	12	10	12	2	1	2	1	1	0	1	6	4	4	2	4	1	0	2	4	1	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:38903644G>C	uc002oir.2	-	12	1676	c.1462C>G	c.(1462-1464)CAG>GAG	p.Q488E	RASGRP4_uc010efz.1_RNA|RASGRP4_uc010ega.1_RNA|RASGRP4_uc010xua.1_Missense_Mutation_p.Q419E|RASGRP4_uc010xub.1_Missense_Mutation_p.Q454E|RASGRP4_uc010xuc.1_Missense_Mutation_p.Q396E|RASGRP4_uc010xud.1_Missense_Mutation_p.Q391E|RASGRP4_uc010xue.1_Missense_Mutation_p.Q299E|RASGRP4_uc010egb.2_Missense_Mutation_p.Q474E	NM_170604	NP_733749	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4 isoform a	488	EF-hand.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			pancreas(1)|lung(1)|skin(1)	3	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AAGTCCTCCTGAGAGATTGTT	0.542													16	75					0	0	0	0	C	38903644	C	C	38903644	3	2	154	1	0	0	0	0	1	0	0	0	13142	1299	45	2	583	2	RASGRP4	19	38903644	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	211099	38903644	20225339	686	28533											
PAF1	54623	broad.mit.edu	37	chr19	39879272	39879272	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaacgtctcttctacaggcAggaaataggccacaaactgg	13	8	9	11	1	3	0	1	0	2	0	4	1	3	1	1	4	3	1	1	4	5	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:39879272A>T	uc002old.2	-	10	960	c.785T>A	c.(784-786)CTG>CAG	p.L262Q	PAF1_uc002ole.1_Missense_Mutation_p.L252Q|PAF1_uc010xuv.1_RNA|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	262					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TTCTACAGGCAGGAAATAGGC	0.527													20	73					0	0	0	0	T	39879272	T	T	39879272	3	4	154	1	0	0	0	0	1	0	0	0	11437	188	7	5	830	5	PAF1	19	39879272	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	975628	39879272	19249711	687	28534											
FCGBP	8857	broad.mit.edu	37	chr19	40366446	40366446	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccggcacgcgcaggcgcacGaagctgtccccatcgaaagc	9	3	13	16	6	0	0	0	0	0	0	2	2	1	0	3	2	2	4	3	2	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:40366446G>A	uc002omp.3	-	30	13796	c.13788C>T	c.(13786-13788)TTC>TTT	p.F4596F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4596	VWFD 11.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCAGGCGCACGAAGCTGTCCC	0.667													12	96					0	0	0	0	A	40366446	A	A	40366446	2	1	154	1	0	0	0	0	0	0	0	1	5810	1049	37	1		1	FCGBP	19	40366446	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	487174	40366446	18762537	688	28535											
LTBP4	8425	broad.mit.edu	37	chr19	41114228	41114228	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggagccaccccgagtgtCactcagccagcctcgtaccc	8	5	9	19	2	2	0	2	0	0	0	3	2	2	1	7	1	4	1	7	1	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:41114228C>T	uc002ooh.1	+	11	1460	c.1460C>T	c.(1459-1461)TCA>TTA	p.S487L	LTBP4_uc002oog.1_Missense_Mutation_p.S450L|LTBP4_uc002ooi.1_Missense_Mutation_p.S420L|LTBP4_uc002ooj.1_5'Flank|LTBP4_uc010xvo.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	487	Pro-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCCCGAGTGTCACTCAGCCAG	0.662													4	22					0	0	0	0	T	41114228	T	T	41114228	3	4	154	1	0	0	0	0	1	0	0	0	9126	838	29	2	1795	2	LTBP4	19	41114228	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	747782	41114228	18014755	689	28536											
MIA	8190	broad.mit.edu	37	chr19	41281750	41281750	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccaagtggtgtatgtcttctCcaagctgaagggccgtgggc	7	10	14	10	1	2	1	0	1	2	0	3	1	2	1	3	3	1	2	3	3	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:41281750C>T	uc002opb.3	+	2	369	c.221C>T	c.(220-222)TCC>TTC	p.S74F	MIA_uc010xvt.1_RNA|RAB4B_uc002opc.1_RNA|RAB4B_uc002opd.1_5'Flank|RAB4B_uc002ope.1_5'Flank|EGLN2_uc010ehd.2_5'Flank	NM_006533	NP_006524	Q16674	MIA_HUMAN	melanoma inhibitory activity precursor	74	SH3.				cell proliferation	extracellular space	growth factor activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)	GBM - Glioblastoma multiforme(1328;0.0199)		TATGTCTTCTCCAAGCTGAAG	0.592													11	47					0	0	0	0	T	41281750	T	T	41281750	3	4	154	1	0	0	0	0	1	0	0	0	9616	855	30	2	227	2	MIA	19	41281750	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	167522	41281750	17847233	690	28537											
GRIK5	2901	broad.mit.edu	37	chr19	42558056	42558056	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgctgttgaactcgaccCgcccggtcagcccatcatac	7	10	8	16	3	2	1	2	1	0	0	3	2	2	1	3	1	4	2	3	1	2	3	rs137900269		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:42558056C>T	uc002osj.1	-	9	1117	c.1082G>A	c.(1081-1083)CGG>CAG	p.R361Q	GRIK5_uc010eib.1_Missense_Mutation_p.R280Q	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	361	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GAACTCGACCCGCCCGGTCAG	0.637													10	25					0	0	0	0	T	42558056	T	T	42558056	3	4	154	1	0	0	0	0	1	0	0	0	6816	652	23	1	1904	1	GRIK5	19	42558056	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1276306	42558056	16570927	691	28538											
ZNF234	10780	broad.mit.edu	37	chr19	44661807	44661807	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tttaaatgtgaagagtgtggGaagagcttcagtcggagtgc	11	11	15	4	1	1	3	1	1	0	2	2	5	1	5	0	2	2	1	0	2	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:44661807G>A	uc002oym.2	+	6	1945	c.1638G>A	c.(1636-1638)GGG>GGA	p.G546G	ZNF234_uc002oyl.3_Silent_p.G546G	NM_006630	NP_006621	Q14588	ZN234_HUMAN	zinc finger protein 234	546	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				AAGAGTGTGGGAAGAGCTTCA	0.483													16	88					0	0	0	0	A	44661807	A	A	44661807	2	1	154	1	0	0	0	0	0	0	0	1	17854	1161	41	2		2	ZNF234	19	44661807	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2103751	44661807	14467176	692	28539											
ZNF233	353355	broad.mit.edu	37	chr19	44778176	44778176	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagaaaccatataaatgtGaggtatgtgataagggcttc	15	10	12	4	0	0	3	0	2	0	1	1	5	0	3	1	2	1	2	1	2	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:44778176G>A	uc002oyz.1	+	5	1490	c.1363G>A	c.(1363-1365)GAG>AAG	p.E455K	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.E270K	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	455	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				ATATAAATGTGAGGTATGTGA	0.403													14	67					0	0	0	0	A	44778176	A	A	44778176	3	1	154	1	0	0	0	0	1	0	0	0	17853	1291	45	2	1377	2	ZNF233	19	44778176	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	116369	44778176	14350807	693	28540											
ZNF285	26974	broad.mit.edu	37	chr19	44892232	44892232	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaacttaacccctttgcctGaagattcaaaatgttgtttt	11	16	6	8	0	1	2	1	1	0	1	1	2	1	2	3	0	3	3	3	0	5	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:44892232G>T	uc002ozd.3	-	4	262	c.175C>A	c.(175-177)CAG>AAG	p.Q59K	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.Q66K	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						CCCTTTGCCTGAAGATTCAAA	0.398													11	72					6.40141e-05	0.000126162	1	0	T	44892232	T	T	44892232	3	4	154	1	0	0	0	0	1	0	0	0	17889	1299	45	2	1601	2	ZNF285	19	44892232	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	114056	44892232	14236751	694	28541											
ZNF296	162979	broad.mit.edu	37	chr19	45575215	45575215	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcagggtcagttctttgttCcgtggtgatggctccccaag	5	13	13	10	1	2	1	1	1	1	0	4	1	4	1	3	3	1	4	3	3	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:45575215C>T	uc002pao.2	-	3	1129	c.1072G>A	c.(1072-1074)GAA>AAA	p.E358K		NM_145288	NP_660331	Q8WUU4	ZN296_HUMAN	zinc finger protein 296	358					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTTCTTTGTTCCGTGGTGATG	0.652													12	149					0	0	0	0	T	45575215	T	T	45575215	3	4	154	1	0	0	0	0	1	0	0	0	17895	864	30	2	359	2	ZNF296	19	45575215	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	682983	45575215	13553768	695	28542											
DACT3	147906	broad.mit.edu	37	chr19	47151869	47151869	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccctgcacctgctccacccCcagaggccgcggtggccgcc	4	4	11	22	3	0	1	0	0	0	1	1	1	1	1	9	3	2	2	9	3	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:47151869C>T	uc010ekq.2	-	4	1834	c.1760G>A	c.(1759-1761)GGG>GAG	p.G587E		NM_145056	NP_659493	Q96B18	DACT3_HUMAN	thymus expressed gene 3-like	587											0		Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000173)|all cancers(93;0.000464)|Epithelial(262;0.02)|GBM - Glioblastoma multiforme(486;0.0325)		TGCTCCACCCCCAGAGGCCGC	0.652													29	116					0	0	0	0	T	47151869	T	T	47151869	3	4	154	1	0	0	0	0	1	0	0	0	4240	623	22	4	133	4	DACT3	19	47151869	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1576654	47151869	11977114	696	28543											
SLC8A2	6543	broad.mit.edu	37	chr19	47969076	47969076	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagtgacaaagaagactctCaggtgcttgatcttgcggct	10	10	12	9	1	2	4	1	2	2	2	3	4	2	4	0	2	2	3	0	2	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:47969076C>T	uc002pgx.2	-	2	863	c.585G>A	c.(583-585)CTG>CTA	p.L195L	SLC8A2_uc010xyq.1_Intron|SLC8A2_uc010xyr.1_Intron|SLC8A2_uc010ele.2_Silent_p.L195L	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	195	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		AGAAGACTCTCAGGTGCTTGA	0.552													6	31					0	0	0	0	T	47969076	T	T	47969076	2	4	154	1	0	0	0	0	0	0	0	1	14771	813	29	2		2	SLC8A2	19	47969076	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	817207	47969076	11159907	697	28544											
TPRX1	284355	broad.mit.edu	37	chr19	48305449	48305449	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgcctgggcctgggatctgGgctgggctgggaatcgggcc	3	8	19	11	1	1	0	0	0	1	0	2	2	1	2	3	6	1	2	3	6	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:48305449G>C	uc002php.1	-	2	890	c.819C>G	c.(817-819)GCC>GCG	p.A273A		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox	273	Gly-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		CTGGGATCTGGGCTGGGCTGG	0.383													4	18					0	0	0	0	C	48305449	C	C	48305449	2	2	154	1	0	0	0	0	0	0	0	1	16489	1219	43	4		4	TPRX1	19	48305449	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	336373	48305449	10823534	698	28545											
SPACA4	171169	broad.mit.edu	37	chr19	49110596	49110596	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggctgggtatgctgcttcctCcacgtttgctgtgaccaaca	6	12	11	12	1	0	1	0	1	0	0	2	1	2	1	3	2	4	6	3	2	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:49110596C>G	uc002pjo.2	+	1	597	c.361C>G	c.(361-363)CCA>GCA	p.P121A	FAM83E_uc002pjn.2_Intron	NM_133498	NP_598005	Q8TDM5	SACA4_HUMAN	sperm acrosomal membrane protein 14 precursor	121					cell adhesion	acrosomal vesicle|anchored to membrane|plasma membrane				central_nervous_system(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		GCTGCTTCCTCCACGTTTGCT	0.637													5	4					0	0	0	0	G	49110596	G	G	49110596	3	3	154	1	0	0	0	0	1	0	0	0	15038	855	30	2	363	2	SPACA4	19	49110596	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	805147	49110596	10018387	699	28546											
RUVBL2	10856	broad.mit.edu	37	chr19	49514288	49514288	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatcaagtcagaagtccgtGagcagatcaatgccaaggtg	14	7	12	8	1	3	4	3	1	0	3	4	4	4	4	2	1	2	1	2	1	4	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:49514288G>C	uc002plr.1	+	10	833	c.820G>C	c.(820-822)GAG>CAG	p.E274Q	RUVBL2_uc002plq.1_Missense_Mutation_p.E229Q|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Missense_Mutation_p.E229Q|RUVBL2_uc010yac.1_Missense_Mutation_p.E229Q	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	274					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		AGAAGTCCGTGAGCAGATCAA	0.627													7	52					0	0	0	0	C	49514288	C	C	49514288	3	2	154	1	0	0	0	0	1	0	0	0	13818	1291	45	2	858	2	RUVBL2	19	49514288	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	403692	49514288	9614695	700	28547											
CCDC155	147872	broad.mit.edu	37	chr19	49912474	49912474	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacctgaaggggcccagctGagaagagtgggctggaccga	10	5	16	10	1	0	3	0	2	0	2	0	6	0	4	3	4	2	2	3	4	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:49912474G>A	uc002pnm.1	+	14	1254	c.1080G>A	c.(1078-1080)CTG>CTA	p.L360L	CCDC155_uc010emx.1_Silent_p.L333L	NM_144688	NP_653289	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	360						integral to membrane	calcium ion binding			ovary(1)|central_nervous_system(1)	2						GGGCCCAGCTGAGAAGAGTGG	0.632													5	19					0	0	0	0	A	49912474	A	A	49912474	2	1	154	1	0	0	0	0	0	0	0	1	2801	1277	45	2		2	CCDC155	19	49912474	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	398186	49912474	9216509	701	28548											
ZNF473	25888	broad.mit.edu	37	chr19	50549315	50549315	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacgagagtgttcacgccAgagaaaaacaaggatttttt	14	9	10	8	2	1	2	1	0	0	2	1	5	1	3	2	1	1	1	2	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:50549315A>C	uc002prn.2	+	5	1852	c.1615A>C	c.(1615-1617)AGA>CGA	p.R539R	ZNF473_uc002prm.2_Silent_p.R539R|ZNF473_uc010ybo.1_Silent_p.R527R	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	539	Interaction with SLBP/pre-mRNA complex.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		TGTTCACGCCAGAGAAAAACA	0.443													14	49					0	0	0	0	C	50549315	C	C	50549315	2	2	154	1	0	0	0	0	0	0	0	1	17998	180	7	5		5	ZNF473	19	50549315	Silent	SNP	A	TCGA-CR-7388-01A-11D-2012-08	636841	50549315	8579668	702	28549											
ACPT	93650	broad.mit.edu	37	chr19	51293713	51293713	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggccaccctgctggacctctCctgctgctgctgctgctggt	2	11	12	16	0	1	0	0	0	1	0	2	1	1	1	4	3	6	6	4	3	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:51293713C>T	uc002pta.1	+	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	14						integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CTGGACCTCTCctgctgctgc	0.627													3	3					0	0	0	0	T	51293713	T	T	51293713	2	4	154	1	0	0	0	0	0	0	0	1	168	842	30	2		2	ACPT	19	51293713	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	744398	51293713	7835270	703	28550											
SIGLEC12	89858	broad.mit.edu	37	chr19	51994940	51994940	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tactcatagccgatggcctcCtgttcctgtgggtactgagg	6	12	12	11	1	1	1	1	1	0	0	3	2	3	1	4	3	3	2	4	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:51994940C>A	uc002pwx.1	-	8	1799	c.1743G>T	c.(1741-1743)CAG>CAT	p.Q581H	SIGLEC12_uc002pww.1_Missense_Mutation_p.Q463H|SIGLEC12_uc010eoy.1_Missense_Mutation_p.Q308H	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	581	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CGATGGCCTCCTGTTCCTGTG	0.582													24	100					3.08376e-08	6.5952e-08	1	0	A	51994940	A	A	51994940	3	1	154	1	0	0	0	0	1	0	0	0	14373	680	24	4	48	4	SIGLEC12	19	51994940	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	701227	51994940	7134043	704	28551											
ZNF808	388558	broad.mit.edu	37	chr19	53058026	53058026	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cataagagaattcatactggAgagaaaccatacagatgtca	18	8	8	7	0	2	3	2	0	0	3	2	6	2	4	1	1	3	0	1	1	5	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:53058026A>G	uc010epq.1	+	5	2034	c.1857A>G	c.(1855-1857)GGA>GGG	p.G619G	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	619					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TTCATACTGGAGAGAAACCAT	0.398													18	63					0	0	0	0	G	53058026	G	G	53058026	2	3	154	1	0	0	0	0	0	0	0	1	18240	291	11	5		5	ZNF808	19	53058026	Silent	SNP	A	TCGA-CR-7388-01A-11D-2012-08	1063086	53058026	6070957	705	28552											
ZNF347	84671	broad.mit.edu	37	chr19	53643887	53643887	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgtaaggtttttttccagTatggattgcctgatgggtag	7	18	12	4	0	0	1	0	1	0	0	1	2	1	2	2	3	1	4	2	3	3	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:53643887T>G	uc002qbb.1	-	5	2263	c.2194A>C	c.(2194-2196)ACT>CCT	p.T732P	ZNF347_uc010eql.1_Missense_Mutation_p.T733P|ZNF347_uc002qbc.1_Missense_Mutation_p.T733P	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	732					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TTTTTTCCAGTATGGATTGCC	0.433													35	123					0	0	0	0	G	53643887	G	G	53643887	3	3	154	1	0	0	0	0	1	0	0	0	17928	1638	57	5	329	5	ZNF347	19	53643887	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	585861	53643887	5485096	706	28553											
NLRP12	91662	broad.mit.edu	37	chr19	54313208	54313208	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggtggctcctggtctcctCgttcaggagtccaaacagga	8	9	12	12	1	2	0	1	0	1	0	6	2	4	2	3	5	1	2	3	5	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:54313208C>T	uc002qch.3	-	3	1925	c.1705G>A	c.(1705-1707)GAG>AAG	p.E569K	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.E569K|NLRP12_uc002qcj.3_Missense_Mutation_p.E569K|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.E569K	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	569					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CTGGTCTCCTCGTTCAGGAGT	0.572													25	72					0	0	0	0	T	54313208	T	T	54313208	3	4	154	1	0	0	0	0	1	0	0	0	10528	893	31	1	1608	1	NLRP12	19	54313208	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	669321	54313208	4815775	707	28554											
LILRB3	11025	broad.mit.edu	37	chr19	54726424	54726424	+	Frame_Shift_Del	DEL	G	-	-																															tcagcccagagggtgggtttGgggaagggccctagatggaa																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:54726424delG	uc002qef.1	-	3	192	c.81delC	c.(79-81)CCCfs	p.P27fs	LILRB3_uc002qee.1_Frame_Shift_Del_p.P27fs|LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	27	Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGTGGGTTTGGGGAAGGGCC	0.632													---	---	---								-	54726424	-	-	54726424	7	5	154	1	0	1	0	1	0	0	0	0	8833	1335	47	0	1861	0	LILRB3	19	54726424	Frame_Shift_Del	DEL	G	TCGA-CR-7388-01A-11D-2012-08	413216	54726424	4402559	708	28555											
LILRB2	10288	broad.mit.edu	37	chr19	54782234	54782234	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaggactcatggggaattCagcctggtacttaggatatt	11	11	11	8	0	2	0	2	0	0	0	2	3	2	3	1	5	2	1	1	5	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:54782234C>G	uc002qfb.2	-	7	1404	c.1138G>C	c.(1138-1140)GAA>CAA	p.E380Q	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.E380Q|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.E380Q|LILRB2_uc010yet.1_Missense_Mutation_p.E264Q|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	380	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ATGGGGAATTCAGCCTGGTAC	0.577													26	188					0	0	0	0	G	54782234	G	G	54782234	3	3	154	1	0	0	0	0	1	0	0	0	8832	835	29	2	690	2	LILRB2	19	54782234	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	55810	54782234	4346749	709	28556											
UBE2S	27338	broad.mit.edu	37	chr19	55915773	55915773	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggtcaggaagtagcccttGggtggggaggcagggaagtc	8	8	19	6	0	1	0	1	0	0	0	2	3	1	3	1	7	1	2	1	7	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:55915773G>A	uc002qkx.1	-	3	593	c.225C>T	c.(223-225)CCC>CCT	p.P75P		NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	75					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		AGTAGCCCTTGGGTGGGGAGG	0.617													5	20					0	0	0	0	A	55915773	A	A	55915773	2	1	154	1	0	0	0	0	0	0	0	1	16940	1335	47	4		4	UBE2S	19	55915773	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1133539	55915773	3213210	710	28557											
NLRP9	338321	broad.mit.edu	37	chr19	56244612	56244612	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggagctccagtaagctggtCtctgcgataccgttcatttc	8	12	10	11	2	2	0	1	0	1	0	5	2	3	1	2	2	4	4	2	2	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:56244612C>G	uc002qly.2	-	2	613	c.585G>C	c.(583-585)GAG>GAC	p.E195D		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	195	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GTAAGCTGGTCTCTGCGATAC	0.458													7	28					0	0	0	0	G	56244612	G	G	56244612	3	3	154	1	0	0	0	0	1	0	0	0	10538	912	32	2	2422	2	NLRP9	19	56244612	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	328839	56244612	2884371	711	28558											
NLRP11	204801	broad.mit.edu	37	chr19	56300718	56300718	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttcattagtagcaataactAtggcaatatattgacagata	16	14	6	5	0	1	2	1	1	0	1	1	2	1	2	0	1	2	3	0	1	9	9			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:56300718A>G	uc010ygf.1	-	10	3272	c.2561T>C	c.(2560-2562)ATA>ACA	p.I854T	NLRP11_uc002qlz.2_Missense_Mutation_p.I701T|NLRP11_uc002qmb.2_Missense_Mutation_p.I755T|NLRP11_uc002qmc.2_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	854							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		AGCAATAACTATGGCAATATA	0.423													25	115					0	0	0	0	G	56300718	G	G	56300718	3	3	154	1	0	0	0	0	1	0	0	0	10527	449	16	5	552	5	NLRP11	19	56300718	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	56106	56300718	2828265	712	28559											
ZNF835	90485	broad.mit.edu	37	chr19	57176264	57176264	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttggggcctccacctctCtcccgctggcggctgtcagg	2	11	12	16	2	3	0	1	0	2	0	6	0	5	0	4	5	0	2	4	5	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:57176264C>G	uc010ygo.1	-	2	369	c.369G>C	c.(367-369)GAG>GAC	p.E123D	ZNF835_uc010ygn.1_Missense_Mutation_p.E101D	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CTCCACCTCTCTCCCGCTGGC	0.642													16	45					0	0	0	0	G	57176264	G	G	57176264	3	3	154	1	0	0	0	0	1	0	0	0	18253	912	32	2	1312	2	ZNF835	19	57176264	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	875546	57176264	1952719	713	28560											
DUXA	503835	broad.mit.edu	37	chr19	57678905	57678905	+	5'Flank	DEL	C	-	-																															tgcgtagccaggtggtcccgCccacttttttaaaccattta																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:57678905delC	uc002qoa.1	-							NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		GGTGGTCCCGCCCACTTTTTT	0.463													---	---	---								-	57678905	-	-	57678905	6	5	154	0	1	1	0	1	0	0	0	0	4856	754	26	0		0	DUXA	19	57678905	5'Flank	DEL	C	TCGA-CR-7388-01A-11D-2012-08	502641	57678905	1450078	714	28561											
ZNF264	9422	broad.mit.edu	37	chr19	57723646	57723646	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccactatgtcatccacaCtggagagaagccctttgagt	11	10	8	12	0	2	2	2	1	0	1	3	4	3	3	3	1	1	0	3	1	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr19:57723646C>T	uc002qob.2	+	4	1594	c.1181C>T	c.(1180-1182)ACT>ATT	p.T394I		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		GTCATCCACACTGGAGAGAAG	0.552													9	56					0	0	0	0	T	57723646	T	T	57723646	3	4	154	1	0	0	0	0	1	0	0	0	17871	565	20	4	1195	4	ZNF264	19	57723646	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	44741	57723646	1405337	715	28562											
SIRPG	55423	broad.mit.edu	37	chr20	1616920	1616920	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctcgcagatgacctgagagCgaacgtcccaggggtccagt	9	6	13	13	3	0	3	0	2	0	2	3	5	2	3	4	2	2	1	4	2	1	0	rs148726891		TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:1616920C>T	uc002wfm.1	-	3	727	c.662G>A	c.(661-663)CGC>CAC	p.R221H	SIRPG_uc002wfn.1_Missense_Mutation_p.R221H|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	221	Extracellular (Potential).|Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						GACCTGAGAGCGAACGTCCCA	0.617													21	75					0	0	0	0	T	1616920	T	T	1616920	3	4	154	1	0	0	0	0	1	0	0	0	14401	768	27	1	513	1	SIRPG	20	1616920	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08		1616920	61408600	716	28563											
VPS16	64601	broad.mit.edu	37	chr20	2842527	2842527	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctcccgcagcacccacgagTtcctgcatgaggttccaggt	7	9	10	15	2	1	1	0	1	1	0	4	2	3	1	4	2	2	5	4	2	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:2842527T>G	uc002whe.2	+	10	1024	c.976T>G	c.(976-978)TTC>GTC	p.F326V	VPS16_uc002whh.2_5'Flank|PTPRA_uc002whj.2_5'Flank|VPS16_uc002whf.2_Intron|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_5'Flank|VPS16_uc002whi.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	326					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						CACCCACGAGTTCCTGCATGA	0.612													10	19					0	0	0	0	G	2842527	G	G	2842527	3	3	154	1	0	0	0	0	1	0	0	0	17261	1725	60	5	1014	5	VPS16	20	2842527	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1225607	2842527	60182993	717	28564											
PLCB4	5332	broad.mit.edu	37	chr20	9416221	9416221	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccctagatatcgtggatgctTtatcagatccaaagaaattt	13	13	7	8	1	1	3	1	0	0	3	3	4	2	4	2	1	1	1	2	1	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:9416221T>G	uc002wnf.2	+	27	2639	c.2503T>G	c.(2503-2505)TTA>GTA	p.L835V	PLCB4_uc010gbw.1_Missense_Mutation_p.L835V|PLCB4_uc010gbx.2_Missense_Mutation_p.L847V|PLCB4_uc002wne.2_Missense_Mutation_p.L835V|PLCB4_uc002wnh.2_Missense_Mutation_p.L682V	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	835					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CGTGGATGCTTTATCAGATCC	0.338													11	65					0	0	0	0	G	9416221	G	G	9416221	3	3	154	1	0	0	0	0	1	0	0	0	12085	1838	64	5	2641	5	PLCB4	20	9416221	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	6573694	9416221	53609299	718	28565											
ASXL1	171023	broad.mit.edu	37	chr20	31023983	31023983	+	Frame_Shift_Del	DEL	A	-	-																															ggatctttacatggtcttggAaaaaacagtggcatggttga																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:31023983delA	uc002wxs.2	+	12	3894	c.3468delA	c.(3466-3468)GGAfs	p.G1156fs	ASXL1_uc010geb.2_Frame_Shift_Del_p.G1047fs	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1156					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						ATGGTCTTGGAAAAAACAGTG	0.507			F|N|Mis		MDS|CMML								---	---	---								-	31023983	-	-	31023983	7	5	154	1	0	1	0	1	0	0	0	0	1068	233	9	0	3524	0	ASXL1	20	31023983	Frame_Shift_Del	DEL	A	TCGA-CR-7388-01A-11D-2012-08	21607762	31023983	32001537	719	28566											
ITCH	83737	broad.mit.edu	37	chr20	33068494	33068494	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagttggactcaaggatttaGaatctattgatccagaattt	13	14	8	6	0	2	3	1	1	1	2	3	5	3	5	1	2	0	1	1	2	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:33068494G>C	uc010geu.1	+	20	2224	c.2032G>C	c.(2032-2034)GAA>CAA	p.E678Q	ITCH_uc002xak.2_Missense_Mutation_p.E637Q|ITCH_uc010zuj.1_Missense_Mutation_p.E527Q	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	678	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						CAAGGATTTAGAATCTATTGA	0.323													18	43					0	0	0	0	C	33068494	C	C	33068494	3	2	154	1	0	0	0	0	1	0	0	0	7907	943	33	2	1975	2	ITCH	20	33068494	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2044511	33068494	29957026	720	28567											
GGT7	2686	broad.mit.edu	37	chr20	33440233	33440233	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcatcaggtcccatgatcagCacctgggcagccgtgggagc	8	7	13	13	1	3	1	3	1	0	0	4	2	4	2	3	3	3	2	3	3	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:33440233C>A	uc002xay.2	-	11	1471	c.1428G>T	c.(1426-1428)GTG>GTT	p.V476V	GGT7_uc010gex.2_5'Flank|GGT7_uc002xaz.1_Silent_p.V493V	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	476	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						CCATGATCAGCACCTGGGCAG	0.592													21	68					5.35356e-11	1.20816e-10	1	0	A	33440233	A	A	33440233	2	1	154	1	0	0	0	0	0	0	0	1	6401	697	25	4		4	GGT7	20	33440233	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	371739	33440233	29585287	721	28568											
GDF5	8200	broad.mit.edu	37	chr20	34022553	34022553	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaatgtcaaacacgtacctCtgcttcctgaccacgggacc	10	9	7	15	2	2	1	1	1	1	0	3	2	3	2	4	1	3	2	4	1	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:34022553C>G	uc002xck.1	-	2	979	c.660G>C	c.(658-660)CAG>CAC	p.Q220H	GDF5_uc010gfc.1_Missense_Mutation_p.Q220H|uc002xcj.2_Missense_Mutation_p.L322V|GDF5_uc010zvc.1_Missense_Mutation_p.Q220H	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	220					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			ACACGTACCTCTGCTTCCTGA	0.612													13	130					0	0	0	0	G	34022553	G	G	34022553	3	3	154	1	0	0	0	0	1	0	0	0	6353	912	32	2	849	2	GDF5	20	34022553	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	582320	34022553	29002967	722	28569											
C20orf117	140710	broad.mit.edu	37	chr20	35441119	35441119	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agacccacctcagaggcataGgaatcattgtcttcagctcg	11	9	9	12	1	4	2	3	0	1	2	5	3	4	3	2	2	1	2	2	2	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:35441119G>A	uc002xgd.1	-	6	2058	c.1731C>T	c.(1729-1731)TCC>TCT	p.S577S	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	577											0		Myeloproliferative disorder(115;0.00874)				CAGAGGCATAGGAATCATTGT	0.562													6	40					0	0	0	0	A	35441119	A	A	35441119	2	1	154	1	0	0	0	0	0	0	0	1	2093	987	35	4		4	C20orf117	20	35441119	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1418566	35441119	27584401	723	28570											
BPI	671	broad.mit.edu	37	chr20	36948668	36948668	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggctgagaccctggatgtaCagatgaaggtgaggctgaca	11	7	15	8	1	0	5	0	4	0	2	0	7	0	6	1	4	1	3	1	4	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:36948668C>A	uc002xib.2	+	7	822	c.760C>A	c.(760-762)CAG>AAG	p.Q254K		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	254					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				CCTGGATGTACAGATGAAGGT	0.468													6	25					0.00116845	0.00222308	1	0	A	36948668	A	A	36948668	3	1	154	1	0	0	0	0	1	0	0	0	1495	479	17	4	786	4	BPI	20	36948668	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1507549	36948668	26076852	724	28571											
SLC32A1	140679	broad.mit.edu	37	chr20	37356754	37356754	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacatcgcagcctgcgtgctCaagggcctcttcgcgctcgt	5	9	11	16	5	2	0	1	0	1	0	5	0	2	0	2	1	3	3	2	1	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:37356754C>A	uc002xjc.2	+	2	1313	c.1050C>A	c.(1048-1050)CTC>CTA	p.L350L		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	350	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CCTGCGTGCTCAAGGGCCTCT	0.617													8	42					1.12685e-05	2.25627e-05	1	0	A	37356754	A	A	37356754	2	1	154	1	0	0	0	0	0	0	0	1	14629	813	29	2		2	SLC32A1	20	37356754	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	408086	37356754	25668766	725	28572											
ZHX3	23051	broad.mit.edu	37	chr20	39832463	39832463	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcatcctcaatctcctcaGgggaccagctgatcccctgc	7	8	10	16	0	3	1	2	1	1	0	6	2	5	2	5	3	2	2	5	3	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:39832463G>C	uc002xjs.1	-	3	1472	c.1094C>G	c.(1093-1095)CCT>CGT	p.P365R	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.P365R|ZHX3_uc002xjt.1_Missense_Mutation_p.P365R|ZHX3_uc002xju.1_Missense_Mutation_p.P365R|ZHX3_uc002xjv.1_Missense_Mutation_p.P365R|ZHX3_uc002xjw.1_Missense_Mutation_p.P365R|ZHX3_uc010ggg.1_Missense_Mutation_p.P365R	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	365	Required for homodimerization and interaction with NFYA.|Required for repressor activity.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				AATCTCCTCAGGGGACCAGCT	0.517													16	54					0	0	0	0	C	39832463	C	C	39832463	3	2	154	1	0	0	0	0	1	0	0	0	17744	1000	35	4	1784	4	ZHX3	20	39832463	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2475709	39832463	23193057	726	28573											
TOX2	84969	broad.mit.edu	37	chr20	42635314	42635314	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctaccactcgctgtgccacgGcctcacccccaacggtctgc	6	7	8	20	3	2	0	1	0	1	0	3	0	2	0	5	2	4	1	5	2	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:42635314G>T	uc002xlf.3	+	3	337	c.320G>T	c.(319-321)GGC>GTC	p.G107V	TOX2_uc010ggo.2_Missense_Mutation_p.G98V|TOX2_uc002xle.3_Missense_Mutation_p.G56V|TOX2_uc010ggp.2_Missense_Mutation_p.G56V|TOX2_uc002xlg.2_Missense_Mutation_p.G56V	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	107	Required for transcriptional activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CTGTGCCACGGCCTCACCCCC	0.622													12	66					4.36969e-10	9.73627e-10	1	0	T	42635314	T	T	42635314	3	4	154	1	0	0	0	0	1	0	0	0	16445	1203	42	4	433	4	TOX2	20	42635314	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2802851	42635314	20390206	727	28574											
JPH2	57158	broad.mit.edu	37	chr20	42743470	42743470	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaacaaagaggatggccaggCcgatgttcagcaggatcacc	13	5	13	10	1	2	1	2	0	0	1	2	5	2	3	3	4	2	2	3	4	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:42743470C>T	uc002xli.1	-	5	2930	c.2057G>A	c.(2056-2058)GGC>GAC	p.G686D		NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	686	Helical; Anchor for type IV membrane protein; (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GATGGCCAGGCCGATGTTCAG	0.637													4	19					0	0	0	0	T	42743470	T	T	42743470	3	4	154	1	0	0	0	0	1	0	0	0	8000	739	26	4	37	4	JPH2	20	42743470	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	108156	42743470	20282050	728	28575											
ZMYND8	23613	broad.mit.edu	37	chr20	45865143	45865143	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggcaggtcagcgttgactGaggacacaagggtgctcatg	9	8	16	8	1	2	2	2	2	0	0	2	3	2	3	0	4	2	3	0	4	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:45865143G>A	uc002xta.1	-	16	2977	c.2723C>T	c.(2722-2724)TCA>TTA	p.S908L	ZMYND8_uc010ghq.1_Missense_Mutation_p.S539L|ZMYND8_uc010ghr.1_Missense_Mutation_p.S837L|ZMYND8_uc002xst.1_Missense_Mutation_p.S790L|ZMYND8_uc002xsu.1_Missense_Mutation_p.S781L|ZMYND8_uc002xsv.1_Missense_Mutation_p.S836L|ZMYND8_uc002xsw.1_Missense_Mutation_p.S614L|ZMYND8_uc002xsx.1_Missense_Mutation_p.S614L|ZMYND8_uc002xsy.1_Missense_Mutation_p.S837L|ZMYND8_uc002xsz.1_Missense_Mutation_p.S799L|ZMYND8_uc010zxy.1_Missense_Mutation_p.S935L|ZMYND8_uc002xtb.1_Missense_Mutation_p.S882L|ZMYND8_uc002xss.2_Missense_Mutation_p.S908L|ZMYND8_uc010zxz.1_Missense_Mutation_p.S776L|ZMYND8_uc002xtc.1_Missense_Mutation_p.S882L|ZMYND8_uc002xtd.1_Missense_Mutation_p.S857L|ZMYND8_uc002xte.1_Missense_Mutation_p.S862L|ZMYND8_uc010zya.1_Missense_Mutation_p.S908L|ZMYND8_uc002xtf.1_Missense_Mutation_p.S928L|ZMYND8_uc002xsr.1_Missense_Mutation_p.S7L	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	908							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			AGCGTTGACTGAGGACACAAG	0.587													11	97					0	0	0	0	A	45865143	A	A	45865143	3	1	154	1	0	0	0	0	1	0	0	0	17778	1294	45	2	953	2	ZMYND8	20	45865143	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3121673	45865143	17160377	729	28576											
C20orf177	63939	broad.mit.edu	37	chr20	58519303	58519303	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatctctctgattcggaaaGaattcccattcctccttctc	8	15	5	13	1	3	3	0	2	3	1	9	4	6	4	3	1	0	0	3	1	2	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:58519303G>A	uc002yba.2	+	5	720	c.305G>A	c.(304-306)AGA>AAA	p.R102K	C20orf177_uc010zzx.1_Intron|C20orf177_uc002ybc.2_Missense_Mutation_p.R102K	NM_022106	NP_071389	Q9NTX9	CT177_HUMAN	hypothetical protein LOC63939	102										ovary(2)|breast(1)	3	all_lung(29;0.00693)		BRCA - Breast invasive adenocarcinoma(7;1.22e-08)			GATTCGGAAAGAATTCCCATT	0.433													7	41					0	0	0	0	A	58519303	A	A	58519303	3	1	154	1	0	0	0	0	1	0	0	0	2106	942	33	2	307	2	C20orf177	20	58519303	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	12654160	58519303	4506217	730	28577											
SS18L1	26039	broad.mit.edu	37	chr20	60733801	60733801	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcaagacggccgagtgcaCgcagtgagtgcccgccatac	9	4	15	13	4	0	2	0	1	0	1	0	3	0	2	3	2	3	3	3	2	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:60733801C>T	uc002ycb.2	+	2	198	c.143C>T	c.(142-144)ACG>ATG	p.T48M	SS18L1_uc011aaa.1_Missense_Mutation_p.T48M|SS18L1_uc002ybz.1_RNA|SS18L1_uc002yca.1_RNA|SS18L1_uc002ycc.1_5'Flank	NM_198935	NP_945173	O75177	CREST_HUMAN	SS18-like protein 1	48	N-terminal auto-inhibitory domain; necessary for interaction with SMARCA4/BRG1 (By similarity).				chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome kinetochore				ovary(2)	2	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.92e-08)			GCCGAGTGCACGCAGTGAGTG	0.607			T	SSX1	synovial sarcoma								9	86					0	0	0	0	T	60733801	T	T	60733801	3	4	154	1	0	0	0	0	1	0	0	0	15242	536	19	1	149	1	SS18L1	20	60733801	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2214498	60733801	2291719	731	28578											
TCFL5	10732	broad.mit.edu	37	chr20	61488904	61488904	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcgcccacattctgaatctCtccaagggctcttcgctcta	7	13	6	15	2	4	1	0	1	4	0	8	1	5	1	2	1	0	2	2	1	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:61488904C>T	uc002ydp.2	-	4	1174	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K	TCFL5_uc002ydo.2_Missense_Mutation_p.E134K|TCFL5_uc002ydq.2_Missense_Mutation_p.E360K	NM_006602	NP_006593	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 protein	361					cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)	1	Breast(26;5.68e-08)					TTCTGAATCTCTCCAAGGGCT	0.562													9	97					0	0	0	0	T	61488904	T	T	61488904	3	4	154	1	0	0	0	0	1	0	0	0	15765	922	32	2	433	2	TCFL5	20	61488904	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	755103	61488904	1536616	732	28579											
DIDO1	11083	broad.mit.edu	37	chr20	61511825	61511825	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtggtccaccaaggtaagagGgtgaggggcctctgctgtcc	7	8	16	10	0	1	2	0	1	1	1	3	2	3	2	4	5	1	2	4	5	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr20:61511825G>A	uc002ydr.1	-	16	5747	c.5483C>T	c.(5482-5484)CCC>CTC	p.P1828L	DIDO1_uc002yds.1_Missense_Mutation_p.P1828L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1828	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					AAGGTAAGAGGGTGAGGGGCC	0.602													19	75					0	0	0	0	A	61511825	A	A	61511825	3	1	154	1	0	0	0	0	1	0	0	0	4544	1232	43	4	1243	4	DIDO1	20	61511825	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	22921	61511825	1513695	733	28580											
TPTE	7179	broad.mit.edu	37	chr21	10996075	10996075	+	RNA	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgaggaatcttttctgatCacagatcttttggttttccc	7	17	7	10	0	4	3	1	2	3	1	5	4	5	4	2	2	0	1	2	2	1	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr21:10996075C>G	uc002yis.1	-	12		c.2111G>C						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTTTCTGATCACAGATCTTT	0.373													3	31					0	0	0	0	G	10996075	G	G	10996075	1	3	154	0	1	0	0	0	0	0	0	0	16497	841	29	2		2	TPTE	21	10996075	RNA	SNP	C	TCGA-CR-7388-01A-11D-2012-08		10996075	37133820	734	28581											
KRTAP13-4	284827	broad.mit.edu	37	chr21	31802642	31802642	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctcctcccgctcctttgggGgctacctgtactacccaggc	4	11	9	17	1	1	0	0	0	1	0	4	0	3	0	5	3	3	3	5	3	3	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr21:31802642G>T	uc011acw.1	+	1	49	c.49G>T	c.(49-51)GGC>TGC	p.G17C		NM_181600	NP_853631	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	17						intermediate filament					0						CTCCTTTGGGGGCTACCTGTA	0.552													26	72					4.59853e-10	1.02332e-09	1	0	T	31802642	T	T	31802642	3	4	154	1	0	0	0	0	1	0	0	0	8564	1232	43	4	51	4	KRTAP13-4	21	31802642	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	20806567	31802642	16327253	735	28582											
DSCAM	1826	broad.mit.edu	37	chr21	41719757	41719757	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagggttgaggatttcaccAttgcggtaccaggagagttc	9	10	13	9	1	1	2	1	1	0	1	2	4	1	3	3	4	2	3	3	4	1	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr21:41719757A>G	uc002yyq.1	-	6	1502	c.1050T>C	c.(1048-1050)AAT>AAC	p.N350N	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	350	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGATTTCACCATTGCGGTACC	0.507													33	105					0	0	0	0	G	41719757	G	G	41719757	2	3	154	1	0	0	0	0	0	0	0	1	4790	214	8	5		5	DSCAM	21	41719757	Silent	SNP	A	TCGA-CR-7388-01A-11D-2012-08	9917115	41719757	6410138	736	28583											
ZNF295	49854	broad.mit.edu	37	chr21	43413920	43413920	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagcagcaaggctgctcttCtcaacaaatagagaggaaga	16	6	10	9	0	2	2	1	0	2	2	3	4	2	3	0	2	4	4	0	2	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr21:43413920C>G	uc002zab.3	-	3	499	c.285G>C	c.(283-285)GAG>GAC	p.E95D	ZNF295_uc002yzz.3_Missense_Mutation_p.E95D|ZNF295_uc002yzy.3_Missense_Mutation_p.E95D|ZNF295_uc002zaa.3_Missense_Mutation_p.E95D|ZNF295_uc010gov.1_Missense_Mutation_p.E95D|ZNF295_uc002zac.2_Missense_Mutation_p.E95D	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	95	Mediates homodimerization.|BTB.				negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GGCTGCTCTTCTCAACAAATA	0.398													6	31					0	0	0	0	G	43413920	G	G	43413920	3	3	154	1	0	0	0	0	1	0	0	0	17894	912	32	2	2919	2	ZNF295	21	43413920	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1694163	43413920	4715975	737	28584											
ZNF295	49854	broad.mit.edu	37	chr21	43414197	43414197	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggttgatgtaatgcagtaatCcctccatggcttgagtttat	9	15	10	7	0	0	2	0	2	0	0	2	2	2	2	2	2	1	6	2	2	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr21:43414197C>G	uc002zab.3	-	3	222	c.8G>C	c.(7-9)GGA>GCA	p.G3A	ZNF295_uc002yzz.3_Missense_Mutation_p.G3A|ZNF295_uc002yzy.3_Missense_Mutation_p.G3A|ZNF295_uc002zaa.3_Missense_Mutation_p.G3A|ZNF295_uc010gov.1_Missense_Mutation_p.G3A|ZNF295_uc002zac.2_Missense_Mutation_p.G3A	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	3					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ATGCAGTAATCCCTCCATGGC	0.373													10	84					0	0	0	0	G	43414197	G	G	43414197	3	3	154	1	0	0	0	0	1	0	0	0	17894	855	30	2	3196	2	ZNF295	21	43414197	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	277	43414197	4715698	738	28585											
SLC19A1	6573	broad.mit.edu	37	chr21	46945761	46945761	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgggaggcccaggccccgCacgtccgagacaatgaaagt	11	3	13	14	4	0	2	0	1	0	1	1	4	1	3	5	3	0	1	5	3	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr21:46945761C>A	uc002zhl.1	-	5	1382	c.1263G>T	c.(1261-1263)GTG>GTT	p.V421V	SLC19A1_uc010gpy.1_Silent_p.V421V|SLC19A1_uc011aft.1_Silent_p.V381V|SLC19A1_uc002zhm.1_Silent_p.V421V|SLC19A1_uc010gpz.1_Silent_p.V300V	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	421	Extracellular (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		CCAGGCCCCGCACGTCCGAGA	0.582													20	59					4.35082e-09	9.50153e-09	1	0	A	46945761	A	A	46945761	2	1	154	1	0	0	0	0	0	0	0	1	14493	697	25	4		4	SLC19A1	21	46945761	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3531564	46945761	1184134	739	28586											
CCT8L2	150160	broad.mit.edu	37	chr22	17072993	17072993	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccagagattggatggccaGggagggcagtgtggccagga	9	5	18	9	0	0	1	0	0	0	1	0	5	0	4	4	6	0	1	4	6	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr22:17072993G>T	uc002zlp.1	-	1	708	c.448C>A	c.(448-450)CTG>ATG	p.L150M		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	150					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGGATGGCCAGGGAGGGCAGT	0.637													26	48					2.12542e-12	4.93591e-12	1	0	T	17072993	T	T	17072993	3	4	154	1	0	0	0	0	1	0	0	0	2976	991	35	4	1229	4	CCT8L2	22	17072993	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08		17072993	34231573	740	28587											
RGL4	266747	broad.mit.edu	37	chr22	24039430	24039430	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cggccatcccggacgacctgGatgtgagtgagcctggggca	7	6	16	12	3	0	2	0	2	0	0	1	5	1	4	4	5	1	1	4	5	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr22:24039430G>C	uc002zxn.2	+	8	2404	c.1234G>C	c.(1234-1236)GAT>CAT	p.D412H	LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Missense_Mutation_p.D412H|RGL4_uc002zxp.1_Missense_Mutation_p.D276H|RGL4_uc002zxq.2_Missense_Mutation_p.D276H	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	412	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						GGACGACCTGGATGTGAGTGA	0.607													6	81					0	0	0	0	C	24039430	C	C	24039430	3	2	154	1	0	0	0	0	1	0	0	0	13344	1174	41	2	1264	2	RGL4	22	24039430	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	6966437	24039430	27265136	741	28588											
SMTN	6525	broad.mit.edu	37	chr22	31492986	31492986	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcccctgcccctgcagatGatggcacacggacggcccgc	7	5	11	18	3	0	2	0	1	0	1	1	3	1	3	5	3	2	2	5	3	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr22:31492986G>A	uc003ajl.1	+	15	2247	c.2029G>A	c.(2029-2031)GAT>AAT	p.D677N	SMTN_uc003ajk.1_Missense_Mutation_p.D677N|SMTN_uc003ajm.1_Missense_Mutation_p.D677N|SMTN_uc011ale.1_Missense_Mutation_p.D762N|SMTN_uc011alf.1_Missense_Mutation_p.D733N|SMTN_uc003ajn.1_Missense_Mutation_p.D700N|SMTN_uc011alg.1_Missense_Mutation_p.D133N|SMTN_uc003ajo.1_Intron|SMTN_uc010gwe.1_Intron	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	677					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						CCCTGCAGATGATGGCACACG	0.657													5	42					0	0	0	0	A	31492986	A	A	31492986	3	1	154	1	0	0	0	0	1	0	0	0	14878	1290	45	2	2083	2	SMTN	22	31492986	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	7453556	31492986	19811580	742	28589											
APOL2	23780	broad.mit.edu	37	chr22	36629289	36629289	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggaaggttttccttaacccTtgagaacgagaaaacaaatt	15	11	8	7	1	0	2	0	1	0	2	1	5	1	3	2	2	3	1	2	2	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr22:36629289T>C	uc003aoz.2	-	3	258	c.-78_splice	c.e3-1		APOL2_uc011amm.1_Splice_Site_p.R86_splice|APOL2_uc003apa.2_Splice_Site	NM_030882	NP_112092	Q9BQE5	APOL2_HUMAN	apolipoprotein L2						acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding				0						TCCTTAACCCTTGAGAACGAG	0.567													30	38					0	0	0	0	C	36629289	C	C	36629289	5	2	154	1	0	0	0	0	0	0	1	0	806	1623	56	5		5	APOL2	22	36629289	Splice_Site	SNP	T	TCGA-CR-7388-01A-11D-2012-08	5136303	36629289	14675277	743	28590											
ENTHD1	150350	broad.mit.edu	37	chr22	40283410	40283410	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttaaccattaccttggtCttttccagcttcatctatgt	7	19	4	11	0	4	0	1	0	3	0	5	0	5	0	3	1	3	1	3	1	3	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr22:40283410C>G	uc003ayg.2	-	2	594	c.343G>C	c.(343-345)GAC>CAC	p.D115H		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	115	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					TTACCTTGGTCTTTTCCAGCT	0.229													4	72					0	0	0	0	G	40283410	G	G	40283410	3	3	154	1	0	0	0	0	1	0	0	0	5161	913	32	2	1504	2	ENTHD1	22	40283410	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	3654121	40283410	11021156	744	28591											
MPPED1	758	broad.mit.edu	37	chr22	43830958	43830958	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcatctctccctgcagggtgGacccggtgcctcacgatgcc	5	9	11	16	2	3	0	2	0	1	0	5	2	4	1	4	3	3	1	4	3	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr22:43830958G>C	uc011apv.1	+	3	452	c.229G>C	c.(229-231)GAC>CAC	p.D77H	MPPED1_uc011apw.1_5'UTR|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Missense_Mutation_p.D77H|MPPED1_uc011apz.1_Missense_Mutation_p.D110H	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	77							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				CTGCAGGGTGGACCCGGTGCC	0.657													14	130					0	0	0	0	C	43830958	C	C	43830958	3	2	154	1	0	0	0	0	1	0	0	0	9794	1174	41	2	235	2	MPPED1	22	43830958	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3547548	43830958	7473608	745	28592											
PNPLA3	80339	broad.mit.edu	37	chr22	44340664	44340664	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgagtgctgatgtgtctgctCcccgcctccaggtaaatact	7	11	10	13	2	1	1	0	1	1	0	3	2	3	1	4	1	3	3	4	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chr22:44340664C>T	uc003bei.1	+	8	1379	c.1206C>T	c.(1204-1206)CTC>CTT	p.L402L	PNPLA3_uc010gzm.1_RNA	NM_025225	NP_079501	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	402	Lumenal (Potential).				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)				TGTGTCTGCTCCCCGCCTCCA	0.567													6	90					0	0	0	0	T	44340664	T	T	44340664	2	4	154	1	0	0	0	0	0	0	0	1	12221	842	30	2		2	PNPLA3	22	44340664	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	509706	44340664	6963902	746	28593											
CSF2RA	1438	broad.mit.edu	37	chrX	1407736	1407736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgggcgaggggtccgaCggccccccgtgacgtccagt	5	6	15	15	5	0	1	0	1	0	0	2	3	2	1	6	4	1	0	6	4	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:1407736C>T	uc010nct.2	+	7	750	c.428C>T	c.(427-429)ACG>ATG	p.T143M	CSF2RA_uc011mhb.1_Missense_Mutation_p.T143M|CSF2RA_uc004cpq.2_Missense_Mutation_p.T143M|CSF2RA_uc004cpn.2_Missense_Mutation_p.T143M|CSF2RA_uc004cpo.2_Missense_Mutation_p.T143M|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Missense_Mutation_p.T10M|CSF2RA_uc004cpp.2_Missense_Mutation_p.T143M|CSF2RA_uc010ncv.2_Missense_Mutation_p.T143M|CSF2RA_uc004cpr.2_Missense_Mutation_p.T143M	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	143	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AGGGGTCCGACGGCCCCCCGT	0.473													25	134					0	0	0	0	T	1407736	T	T	1407736	3	4	154	1	0	0	0	0	1	0	0	0	3951	536	19	1	442	1	CSF2RA	23	1407736	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08		1407736	153862824	747	28594											
WWC3	55841	broad.mit.edu	37	chrX	10092369	10092369	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggagatccccagatccacGtgggactcctgtgagtacag	10	7	12	12	2	0	3	0	1	0	2	3	5	3	4	4	2	1	1	4	2	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:10092369G>T	uc004csx.3	+	13	2014	c.1816G>T	c.(1816-1818)GTG>TTG	p.V606L	WWC3_uc010nds.2_Missense_Mutation_p.V270L|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	606										ovary(4)	4						CCAGATCCACGTGGGACTCCT	0.607													23	43					9.95505e-16	2.39084e-15	1	0	T	10092369	T	T	10092369	3	4	154	1	0	0	0	0	1	0	0	0	17481	1145	40	3	1862	3	WWC3	23	10092369	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	8684633	10092369	145178191	748	28595											
ARHGAP6	395	broad.mit.edu	37	chrX	11272776	11272776	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagagactctggatggggaCtgacctcagccgtacactgc	9	8	13	11	1	2	3	1	2	1	1	2	6	2	5	2	3	3	1	2	3	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:11272776C>G	uc004cup.1	-	2	1513	c.640G>C	c.(640-642)GTC>CTC	p.V214L	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.V214L|ARHGAP6_uc004cum.1_Missense_Mutation_p.V11L|ARHGAP6_uc004cun.1_Missense_Mutation_p.V34L|ARHGAP6_uc010neb.1_Missense_Mutation_p.V36L|ARHGAP6_uc011mif.1_Missense_Mutation_p.V11L	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	214					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						TGGATGGGGACTGACCTCAGC	0.488													9	88					0	0	0	0	G	11272776	G	G	11272776	3	3	154	1	0	0	0	0	1	0	0	0	887	565	20	4	2454	4	ARHGAP6	23	11272776	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1180407	11272776	143997784	749	28596											
TLR8	51311	broad.mit.edu	37	chrX	12937728	12937728	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taacaaagtttgcgagaaaaCtaacatagaagatggagtat	19	9	9	4	1	0	3	0	0	0	3	0	5	0	4	0	1	4	2	0	1	8	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:12937728C>A	uc004cve.2	+	2	637	c.569C>A	c.(568-570)ACT>AAT	p.T190N	TLR8_uc004cvd.2_Missense_Mutation_p.T208N	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	190	Extracellular (Potential).|LRR 3.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TGCGAGAAAACTAACATAGAA	0.358													27	75					7.92952e-12	1.81276e-11	1	0	A	12937728	A	A	12937728	3	1	154	1	0	0	0	0	1	0	0	0	16023	565	20	4	575	4	TLR8	23	12937728	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1664952	12937728	142332832	750	28597											
AP1S2	8905	broad.mit.edu	37	chrX	15863569	15863569	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggatgtttcctgaacttccCctcccaaaagaaactcatcc	11	11	5	14	0	1	2	1	1	0	1	5	3	5	3	5	1	2	1	5	1	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:15863569C>A	uc004cxi.2	-	4	649	c.359G>T	c.(358-360)GGG>GTG	p.G120V	AP1S2_uc004cxh.2_Missense_Mutation_p.G120V|AP1S2_uc010nex.2_Missense_Mutation_p.G162V|AP1S2_uc011mis.1_Missense_Mutation_p.G162V|AP1S2_uc011mit.1_Missense_Mutation_p.G162V|AP1S2_uc011miu.1_Missense_Mutation_p.G162V	NM_003916	NP_003907	P56377	AP1S2_HUMAN	adaptor-related protein complex 1 sigma 2	120					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	AP-type membrane coat adaptor complex|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein transporter activity				0	Hepatocellular(33;0.183)					CTGAACTTCCCCTCCCAAAAG	0.338													21	73					5.35047e-06	1.08741e-05	1	0	A	15863569	A	A	15863569	3	1	154	1	0	0	0	0	1	0	0	0	737	623	22	4	122	4	AP1S2	23	15863569	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2925841	15863569	139406991	751	28598											
NHS	4810	broad.mit.edu	37	chrX	17746379	17746379	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atattgcttcaggtatttcaGccaaaagtgcctctgataac	12	13	7	9	0	3	1	2	1	1	0	3	1	3	1	2	1	4	2	2	1	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:17746379G>T	uc004cxx.2	+	6	4428	c.4090G>T	c.(4090-4092)GCC>TCC	p.A1364S	NHS_uc011mix.1_Missense_Mutation_p.A1385S|NHS_uc004cxy.2_Missense_Mutation_p.A1208S|NHS_uc004cxz.2_Missense_Mutation_p.A1187S|NHS_uc004cya.2_Missense_Mutation_p.A1087S	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1364						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					AGGTATTTCAGCCAAAAGTGC	0.403													17	36					5.3912e-06	1.09316e-05	1	0	T	17746379	T	T	17746379	3	4	154	1	0	0	0	0	1	0	0	0	10465	971	34	4	4217	4	NHS	23	17746379	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1882810	17746379	137524181	752	28599											
BEND2	139105	broad.mit.edu	37	chrX	18221663	18221663	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agatgacaaggctctacctgGgcccacattttcattttctg	9	13	8	11	0	3	2	1	1	2	1	3	2	3	2	2	2	1	1	2	2	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:18221663G>T	uc004cyj.3	-	5	1019	c.865C>A	c.(865-867)CCA>ACA	p.P289T	BEND2_uc010nfb.2_Missense_Mutation_p.P289T	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	289										ovary(3)|kidney(1)|central_nervous_system(1)	5						GCTCTACCTGGGCCCACATTT	0.418													28	95					9.39395e-14	2.21375e-13	1	0	T	18221663	T	T	18221663	3	4	154	1	0	0	0	0	1	0	0	0	1400	1232	43	4	1600	4	BEND2	23	18221663	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	475284	18221663	137048897	753	28600											
RS1	6247	broad.mit.edu	37	chrX	18660202	18660202	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagcccagcgggatgaggcgGatgaagcgggagatgatggg	10	4	20	7	3	0	4	0	3	0	1	0	7	0	6	1	5	3	0	1	5	1	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:18660202G>T	uc004cyo.2	-	6	632	c.597C>A	c.(595-597)ATC>ATA	p.I199I	CDKL5_uc004cym.2_Intron|CDKL5_uc004cyn.2_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein	199	F5/8 type C.		I -> T (in XLRS1).		cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					GGATGAGGCGGATGAAGCGGG	0.617													22	72					7.87624e-14	1.86108e-13	1	0	T	18660202	T	T	18660202	2	4	154	1	0	0	0	0	0	0	0	1	13758	1164	41	2		2	RS1	23	18660202	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	438539	18660202	136610358	754	28601											
PPEF1	5475	broad.mit.edu	37	chrX	18842187	18842187	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttccagaatatccgcattGaaaaacctgtacaagaggca	15	8	8	10	1	0	3	0	1	0	2	2	3	2	3	3	1	2	4	3	1	6	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:18842187G>A	uc004cyq.2	+	17	2129	c.1648G>A	c.(1648-1650)GAA>AAA	p.E550K	PPEF1_uc004cyp.2_Missense_Mutation_p.E522K|PPEF1_uc004cyr.2_Missense_Mutation_p.E488K|PPEF1_uc004cys.2_Missense_Mutation_p.E550K|PPEF1_uc011mja.1_Missense_Mutation_p.E485K|PPEF1_uc011mjb.1_Missense_Mutation_p.E494K	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	550					detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					TATCCGCATTGAAAAACCTGT	0.418													9	56					0	0	0	0	A	18842187	A	A	18842187	3	1	154	1	0	0	0	0	1	0	0	0	12362	1291	45	2	1702	2	PPEF1	23	18842187	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	181985	18842187	136428373	755	28602											
MAP3K15	389840	broad.mit.edu	37	chrX	19475138	19475138	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaccatcgcatcatagtcCtgttggcaagaggtcccaaa	11	10	8	12	1	2	1	2	0	0	1	5	1	4	1	3	2	0	3	3	2	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:19475138C>A	uc004czk.1	-	5	780	c.-857_splice	c.e5-1		MAP3K15_uc004czj.1_Splice_Site	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase								ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					CATCATAGTCCTGTTGGCAAG	0.458													6	25					2.0095e-06	4.12217e-06	1	0	A	19475138	A	A	19475138	5	1	154	1	0	0	0	0	0	0	1	0	9302	695	24	4	3149	4	MAP3K15	23	19475138	Splice_Site	SNP	C	TCGA-CR-7388-01A-11D-2012-08	632951	19475138	135795422	756	28603											
SH3KBP1	30011	broad.mit.edu	37	chrX	19854368	19854368	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtcagctcatcatcgtgctGggcctggtagtcaaactcca	8	10	10	13	2	4	0	4	0	0	0	6	0	5	0	2	2	3	3	2	2	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:19854368G>T	uc004czm.2	-	2	353	c.37C>A	c.(37-39)CAG>AAG	p.Q13K		NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	13	SH3 1.				apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						TCATCGTGCTGGGCCTGGTAG	0.532													44	110					1.32136e-16	3.18211e-16	1	0	T	19854368	T	T	19854368	3	4	154	1	0	0	0	0	1	0	0	0	14320	1357	47	4	2099	4	SH3KBP1	23	19854368	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	379230	19854368	135416192	757	28604											
KLHL34	257240	broad.mit.edu	37	chrX	21675204	21675204	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagagcccgagtacacgcGccgcagtacgtcggcgggaa	9	3	15	14	7	0	1	0	0	0	1	1	3	0	2	3	2	3	3	3	2	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:21675204G>T	uc004czz.1	-	1	1245	c.703C>A	c.(703-705)CGC>AGC	p.R235S		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	235	BACK.									ovary(1)	1						GAGTACACGCGCCGCAGTACG	0.667													36	32					6.19805e-25	1.53684e-24	1	0	T	21675204	T	T	21675204	3	4	154	1	0	0	0	0	1	0	0	0	8426	1087	38	3	1235	3	KLHL34	23	21675204	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1820836	21675204	133595356	758	28605											
YY2	404281	broad.mit.edu	37	chrX	21875297	21875297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcattgatctctcagatcCtaaacagctggcagaattta	13	11	8	9	0	2	3	1	1	1	2	4	3	3	3	1	2	2	3	1	2	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:21875297C>T	uc011mjp.1	+	1	695	c.695C>T	c.(694-696)CCT>CTT	p.P232L	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Missense_Mutation_p.P450L|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						CTCTCAGATCCTAAACAGCTG	0.483													179	219					0	0	0	0	T	21875297	T	T	21875297	3	4	154	1	0	0	0	0	1	0	0	0	17577	681	24	4	697	4	YY2	23	21875297	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	200093	21875297	133395263	759	28606											
ACOT9	23597	broad.mit.edu	37	chrX	23749058	23749058	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatcctgtgatttagccaaGaaactatgaagtaatttcct	13	13	6	9	0	0	3	0	2	0	1	2	3	2	3	4	0	2	1	4	0	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:23749058G>A	uc004dap.2	-	4	356	c.210C>T	c.(208-210)TTC>TTT	p.F70F	ACOT9_uc004dao.2_Silent_p.F79F|ACOT9_uc004daq.2_Silent_p.F28F|ACOT9_uc004dar.2_Silent_p.F10F|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Silent_p.F10F|ACOT9_uc004dat.1_Silent_p.F70F	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	70					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						ATTTAGCCAAGAAACTATGAA	0.418													7	138					0	0	0	0	A	23749058	A	A	23749058	2	1	154	1	0	0	0	0	0	0	0	1	157	933	33	2		2	ACOT9	23	23749058	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1873761	23749058	131521502	760	28607											
POLA1	5422	broad.mit.edu	37	chrX	24742495	24742495	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaacaggaactccaatttCaatgaaggatgtttatgagg	16	10	10	5	0	1	3	1	2	0	1	2	5	2	5	1	3	2	1	1	3	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:24742495C>T	uc004dbl.2	+	12	1249	c.1226C>T	c.(1225-1227)TCA>TTA	p.S409L	POLA1_uc004dbm.2_Missense_Mutation_p.S415L|POLA1_uc004dbn.2_Missense_Mutation_p.S273L	NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	409					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	ACTCCAATTTCAATGAAGGAT	0.328													7	69					0	0	0	0	T	24742495	T	T	24742495	3	4	154	1	0	0	0	0	1	0	0	0	12242	838	29	2	1272	2	POLA1	23	24742495	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	993437	24742495	130528065	761	28608											
MAGEB6	158809	broad.mit.edu	37	chrX	26212208	26212208	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agttgtttcatattcaaaatCcgatgtggctgccaacggcc	10	12	9	10	2	2	0	2	0	0	0	3	1	3	0	3	2	2	3	3	2	4	4	rs138482118	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:26212208C>A	uc004dbr.2	+	2	394	c.245C>A	c.(244-246)TCC>TAC	p.S82Y	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	82	Ser-rich.									ovary(3)	3						TATTCAAAATCCGATGTGGCT	0.542													22	70					1.96292e-10	4.39595e-10	1	0	A	26212208	A	A	26212208	3	1	154	1	0	0	0	0	1	0	0	0	9232	855	30	2	247	2	MAGEB6	23	26212208	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1469713	26212208	129058352	762	28609											
DCAF8L2	347442	broad.mit.edu	37	chrX	27766844	27766844	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgaagaatcggatgagtCttccagcacttcagagacat	14	9	10	8	1	2	5	1	2	1	3	4	7	3	6	1	1	1	1	1	1	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:27766844C>G	uc011mjy.1	+	1	1919	c.1832C>G	c.(1831-1833)TCT>TGT	p.S611C		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						TCGGATGAGTCTTCCAGCACT	0.527													6	16					0	0	0	0	G	27766844	G	G	27766844	3	3	154	1	0	0	0	0	1	0	0	0	4295	913	32	2	1834	2	DCAF8L2	23	27766844	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1554636	27766844	127503716	763	28610											
MAGEB3	4114	broad.mit.edu	37	chrX	30254265	30254265	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actatccaccactacatctgTagatgtttcttacaaaaagt	14	13	4	10	0	2	1	0	0	2	1	3	1	3	1	2	0	2	2	2	0	6	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:30254265T>C	uc004dca.1	+	5	961	c.224T>C	c.(223-225)GTA>GCA	p.V75A		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	75											0						ACTACATCTGTAGATGTTTCT	0.458													5	17					0	0	0	0	C	30254265	C	C	30254265	3	2	154	1	0	0	0	0	1	0	0	0	9230	1638	57	5	226	5	MAGEB3	23	30254265	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	2487421	30254265	125016295	764	28611											
MAGEB1	4112	broad.mit.edu	37	chrX	30269583	30269583	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccagtgttagagccaggCgtcgcactactgccacgact	9	8	11	13	3	0	1	0	0	0	1	2	3	1	1	3	1	3	2	3	1	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:30269583C>A	uc004dcc.2	+	4	1293	c.973C>A	c.(973-975)CGT>AGT	p.R325S	MAGEB1_uc004dcd.2_Missense_Mutation_p.R325S|MAGEB1_uc004dce.2_Missense_Mutation_p.R325S	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	325											0						TAGAGCCAGGCGTCGCACTAC	0.527													19	76					4.96729e-08	1.05592e-07	1	0	A	30269583	A	A	30269583	3	1	154	1	0	0	0	0	1	0	0	0	9225	768	27	3	975	3	MAGEB1	23	30269583	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	15318	30269583	125000977	765	28612											
GK	2710	broad.mit.edu	37	chrX	30738843	30738843	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagctacaagcagacattCtgtatataccagtaggttag	13	11	9	8	0	1	1	0	0	1	1	1	1	1	1	1	1	5	6	1	1	7	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:30738843C>A	uc004dch.3	+	17	1521	c.1342C>A	c.(1342-1344)CTG>ATG	p.L448M	GK_uc010ngj.2_Missense_Mutation_p.L442M|GK_uc004dci.3_Missense_Mutation_p.L442M|GK_uc011mjz.1_Missense_Mutation_p.L243M|GK_uc011mka.1_Missense_Mutation_p.L285M|GK_uc010ngk.2_Missense_Mutation_p.L237M	NM_203391	NP_976325	P32189	GLPK_HUMAN	glycerol kinase isoform a	448					glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)	1						AGCAGACATTCTGTATATACC	0.398													32	86					3.03874e-20	7.4093e-20	1	0	A	30738843	A	A	30738843	3	1	154	1	0	0	0	0	1	0	0	0	6457	912	32	2	1408	2	GK	23	30738843	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	469260	30738843	124531717	766	28613											
TAB3	257397	broad.mit.edu	37	chrX	30872655	30872655	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctattaattgctgtcccaGgtctttgagaaggttcaact	9	15	8	9	0	2	1	1	1	1	1	4	2	4	1	2	2	2	2	2	2	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:30872655G>T	uc004dcj.2	-	6	1790	c.1127C>A	c.(1126-1128)CCT>CAT	p.P376H	TAB3_uc004dck.2_Missense_Mutation_p.P376H|TAB3_uc010ngl.2_Missense_Mutation_p.P376H	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	376	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						TGCTGTCCCAGGTCTTTGAGA	0.438													30	116					5.60225e-13	1.30447e-12	1	0	T	30872655	T	T	30872655	3	4	154	1	0	0	0	0	1	0	0	0	15563	1000	35	4	1035	4	TAB3	23	30872655	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	133812	30872655	124397905	767	28614											
DMD	1756	broad.mit.edu	37	chrX	31792249	31792249	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagatggcatttctagtttgGagatggcagtttccttagta	10	15	11	5	0	1	2	0	0	1	2	2	3	2	2	1	3	0	5	1	3	4	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:31792249G>T	uc004dda.1	-	51	7614	c.7370C>A	c.(7369-7371)TCC>TAC	p.S2457Y	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.S1113Y|DMD_uc004dcx.2_Missense_Mutation_p.S1116Y|DMD_uc004dcz.2_Missense_Mutation_p.S2334Y|DMD_uc004dcy.1_Missense_Mutation_p.S2453Y|DMD_uc004ddb.1_Missense_Mutation_p.S2449Y|DMD_uc004ddd.1_5'UTR	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2457					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTCTAGTTTGGAGATGGCAGT	0.433													17	55					2.4624e-09	5.41112e-09	1	0	T	31792249	T	T	31792249	3	4	154	1	0	0	0	0	1	0	0	0	4602	1174	41	2	3951	2	DMD	23	31792249	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	919594	31792249	123478311	768	28615											
FAM47A	158724	broad.mit.edu	37	chrX	34149176	34149176	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccaggcggagatggcacactCcagtcttgggaggcactggg	8	6	16	11	1	1	1	0	0	1	1	2	3	2	2	2	6	0	2	2	6	0	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:34149176C>G	uc004ddg.2	-	1	1253	c.1220G>C	c.(1219-1221)GGA>GCA	p.G407A		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	407										ovary(4)|central_nervous_system(1)	5						ATGGCACACTCCAGTCTTGGG	0.567													16	75					0	0	0	0	G	34149176	G	G	34149176	3	3	154	1	0	0	0	0	1	0	0	0	5601	855	30	2	1159	2	FAM47A	23	34149176	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2356927	34149176	121121384	769	28616											
FAM47B	170062	broad.mit.edu	37	chrX	34962278	34962278	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aactgtttcaggaagatacaCcaagcacaatggagtgtgtt	14	10	10	7	0	1	1	1	0	0	1	1	3	1	3	1	2	3	3	1	2	5	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:34962278C>T	uc004ddi.1	+	1	1348	c.1330C>T	c.(1330-1332)CCA>TCA	p.P444S		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	444										ovary(3)|breast(1)	4						GGAAGATACACCAAGCACAAT	0.512													17	93					0	0	0	0	T	34962278	T	T	34962278	3	4	154	1	0	0	0	0	1	0	0	0	5602	507	18	4	1332	4	FAM47B	23	34962278	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	813102	34962278	120308282	770	28617											
FAM47C	442444	broad.mit.edu	37	chrX	37028425	37028425	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctccgcccggagcctcccAatactggagtgtcccatctc	6	9	9	17	2	2	0	0	0	2	0	6	2	4	2	5	2	2	0	5	2	2	1	rs145580328	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:37028425A>G	uc004ddl.1	+	1	1956	c.1942A>G	c.(1942-1944)AAT>GAT	p.N648D		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	648										ovary(3)	3						GGAGCCTCCCAATACTGGAGT	0.642													5	125					0	0	0	0	G	37028425	G	G	37028425	3	3	154	1	0	0	0	0	1	0	0	0	5603	130	5	5	1944	5	FAM47C	23	37028425	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	2066147	37028425	118242135	771	28618											
CXorf27	25763	broad.mit.edu	37	chrX	37850395	37850395	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccacagcgctgagagtgaTgtgactcgctttttgtttga	7	13	11	10	2	0	4	0	4	0	1	1	5	0	4	2	0	1	3	2	0	0	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:37850395T>A	uc004ddt.3	+	1	326	c.303T>A	c.(301-303)GAT>GAA	p.D101E		NM_012274	NP_036406	O75409	HYPM_HUMAN	Huntingtin interacting protein M	101							DNA binding			central_nervous_system(1)	1						CTGAGAGTGATGTGACTCGCT	0.527													11	31					0	0	0	0	A	37850395	A	A	37850395	3	1	154	1	0	0	0	0	1	0	0	0	4122	1461	51	5	305	5	CXorf27	23	37850395	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	821970	37850395	117420165	772	28619											
BCOR	54880	broad.mit.edu	37	chrX	39932751	39932751	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgggttgctggctttggcGcccttgctgctggtgctgct	0	15	15	11	1	1	0	0	0	1	0	1	0	1	0	1	4	5	7	1	4	0	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:39932751G>T	uc004den.3	-	4	2140	c.1848C>A	c.(1846-1848)GGC>GGA	p.G616G	BCOR_uc004dep.3_Silent_p.G616G|BCOR_uc004deo.3_Silent_p.G616G|BCOR_uc004dem.3_Silent_p.G616G|BCOR_uc004deq.3_Silent_p.G616G	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	616					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TGGCTTTGGCGCCCTTGCTGC	0.567													22	67					4.26978e-12	9.78653e-12	1	0	T	39932751	T	T	39932751	2	4	154	1	0	0	0	0	0	0	0	1	1388	1074	38	3		3	BCOR	23	39932751	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2082356	39932751	115337809	773	28620											
SSX5	6758	broad.mit.edu	37	chrX	48049698	48049698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcctctgctggcttctcggGcgtgatctttataatgtgaa	6	16	10	9	2	3	2	0	2	3	0	5	2	4	2	1	2	1	2	1	2	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:48049698G>A	uc004dja.1	-	6	390	c.337C>T	c.(337-339)CCC>TCC	p.P113S	SSX5_uc004diz.1_Missense_Mutation_p.P154S	NM_175723	NP_783729	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5 isoform b	113					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						GGCTTCTCGGGCGTGATCTTT	0.348													54	243					0	0	0	0	A	48049698	A	A	48049698	3	1	154	1	0	0	0	0	1	0	0	0	15274	1203	42	4	237	4	SSX5	23	48049698	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	8116947	48049698	107220862	774	28621											
WAS	7454	broad.mit.edu	37	chrX	48542680	48542680	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctctcccagacgctggcCactgcagttgttcagctgta	6	12	9	14	1	2	1	1	0	1	1	4	1	3	1	3	1	2	6	3	1	1	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:48542680C>A	uc004dkm.3	+	2	198	c.141C>A	c.(139-141)GCC>GCA	p.A47A		NM_000377	NP_000368	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome protein	47	WH1.				blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			ovary(1)	1		all_lung(315;1.27e-10)				AGACGCTGGCCACTGCAGTTG	0.602			Mis|N|F|S			lymphoma			Wiskott-Aldrich_syndrome				18	48					2.35188e-11	5.33498e-11	1	0	A	48542680	A	A	48542680	2	1	154	1	0	0	0	0	0	0	0	1	17319	581	21	4		4	WAS	23	48542680	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	492982	48542680	106727880	775	28622											
HDAC6	10013	broad.mit.edu	37	chrX	48672940	48672940	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accacaggtttcggccaaggCcaaggatataccatcaatgt	13	8	9	11	1	1	0	1	0	0	0	2	1	1	1	4	4	1	1	4	4	5	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:48672940C>A	uc011mmi.1	+	11	995	c.900C>A	c.(898-900)GGC>GGA	p.G300G	HDAC6_uc004dks.1_Silent_p.G300G|HDAC6_uc010nig.1_Silent_p.G148G|HDAC6_uc004dkt.1_Silent_p.G300G|HDAC6_uc011mmj.1_Silent_p.G245G|HDAC6_uc011mmk.1_Silent_p.G281G|HDAC6_uc004dkv.1_5'UTR|HDAC6_uc004dkw.1_5'UTR	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	300	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	TCGGCCAAGGCCAAGGATATA	0.602													11	56					1.33987e-11	3.05116e-11	1	0	A	48672940	A	A	48672940	2	1	154	1	0	0	0	0	0	0	0	1	7050	726	26	4		4	HDAC6	23	48672940	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	130260	48672940	106597620	776	28623											
KCND1	3750	broad.mit.edu	37	chrX	48826247	48826247	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcatcctctgccaggcgctcGgcattctccttctttcggtc	3	14	8	16	3	4	0	1	0	3	0	9	0	5	0	3	3	1	2	3	3	0	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:48826247G>T	uc004dlx.1	-	1	2005	c.432C>A	c.(430-432)GCC>GCA	p.A144A	KCND1_uc004dlw.1_5'Flank	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	144	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						CCAGGCGCTCGGCATTCTCCT	0.657													9	19					1.12685e-05	2.25627e-05	1	0	T	48826247	T	T	48826247	2	4	154	1	0	0	0	0	0	0	0	1	8057	1103	39	3		3	KCND1	23	48826247	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	153307	48826247	106444313	777	28624											
CCDC120	90060	broad.mit.edu	37	chrX	48921431	48921431	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccctgagtgcccactagagCctggtgaacggccccagttg	7	7	12	15	1	0	3	0	2	0	1	0	3	0	3	6	2	3	1	6	2	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:48921431C>A	uc010nik.2	+	5	730	c.223C>A	c.(223-225)CCT>ACT	p.P75T	CCDC120_uc011mmq.1_Missense_Mutation_p.P63T|CCDC120_uc004dmf.2_Missense_Mutation_p.P75T|CCDC120_uc010nil.2_Missense_Mutation_p.P75T|CCDC120_uc011mmr.1_Missense_Mutation_p.P75T|CCDC120_uc011mms.1_Missense_Mutation_p.P63T	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	75							protein binding			pancreas(1)	1						CCCACTAGAGCCTGGTGAACG	0.657													6	24					0.000157383	0.000305386	1	0	A	48921431	A	A	48921431	3	1	154	1	0	0	0	0	1	0	0	0	2768	739	26	4	233	4	CCDC120	23	48921431	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	95184	48921431	106349129	778	28625											
PPP1R3F	89801	broad.mit.edu	37	chrX	49142667	49142667	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacgggctgctgtggctgcGggtggggcagggggtggtgg	2	8	24	7	2	0	0	0	0	0	0	0	0	0	0	0	9	3	4	0	9	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:49142667G>C	uc004dnh.1	+	4	1531	c.1515G>C	c.(1513-1515)GCG>GCC	p.A505A	PPP1R3F_uc011mnd.1_Silent_p.A176A|PPP1R3F_uc004dni.2_Silent_p.A159A|PPP1R3F_uc004dnj.1_Silent_p.A159A	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	505	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					CTGTGGCTGCGGGTGGGGCAG	0.657													7	18					0	0	0	0	C	49142667	C	C	49142667	2	2	154	1	0	0	0	0	0	0	0	1	12435	1103	39	3		3	PPP1R3F	23	49142667	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	221236	49142667	106127893	779	28626											
CCNB3	85417	broad.mit.edu	37	chrX	50089707	50089707	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgtgatgataattatcaGcgatctgaggtactcagcat	12	13	9	7	1	4	3	2	3	2	0	4	4	4	3	0	1	3	2	0	1	3	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:50089707G>A	uc004dox.3	+	10	4009	c.3711G>A	c.(3709-3711)CAG>CAA	p.Q1237Q	CCNB3_uc004doy.2_Silent_p.Q1237Q|CCNB3_uc004doz.2_Silent_p.Q133Q|CCNB3_uc010njq.2_Silent_p.Q129Q|CCNB3_uc004dpa.2_Silent_p.Q76Q	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1237					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					ATAATTATCAGCGATCTGAGG	0.473													23	75					0	0	0	0	A	50089707	A	A	50089707	2	1	154	1	0	0	0	0	0	0	0	1	2929	962	34	4		4	CCNB3	23	50089707	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	947040	50089707	105180853	780	28627											
SHROOM4	57477	broad.mit.edu	37	chrX	50376525	50376525	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgggagtttctgactgaaGgggtgacatggaatgatatg	11	11	16	3	0	1	4	0	4	1	0	1	6	1	6	0	4	0	1	0	4	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:50376525G>T	uc004dpe.2	-	4	2574	c.2548C>A	c.(2548-2550)CTT>ATT	p.L850I	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.L734I	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	850					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					TCTGACTGAAGGGGTGACATG	0.443													23	111					1.1804e-14	2.80424e-14	1	0	T	50376525	T	T	50376525	3	4	154	1	0	0	0	0	1	0	0	0	14361	1000	35	4	1957	4	SHROOM4	23	50376525	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	286818	50376525	104894035	781	28628											
GSPT2	23708	broad.mit.edu	37	chrX	51488376	51488376	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcatacttgtattgaggaaGttgagataacagcgttaatc	13	14	9	5	1	1	2	1	2	0	1	2	4	1	3	0	1	3	3	0	1	5	8			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:51488376G>T	uc004dpl.2	+	1	1880	c.1654G>T	c.(1654-1656)GTT>TTT	p.V552F		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	552					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					TATTGAGGAAGTTGAGATAAC	0.418													31	91					1.88708e-17	4.56326e-17	1	0	T	51488376	T	T	51488376	3	4	154	1	0	0	0	0	1	0	0	0	6866	1029	36	4	1656	4	GSPT2	23	51488376	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1111851	51488376	103782184	782	28629											
XAGE5	170627	broad.mit.edu	37	chrX	52844169	52844169	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagtcaaagactggggatGaatgcggagatagtcctgat	12	9	13	7	1	2	4	2	2	0	2	3	6	3	5	1	3	1	0	1	3	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:52844169G>T	uc004drd.1	+	4	297	c.232G>T	c.(232-234)GAA>TAA	p.E78*		NM_130775	NP_570131	Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	78										ovary(1)	1						GACTGGGGATGAATGCGGAGA	0.428													6	52					0.00198382	0.003734	1	0	T	52844169	T	T	52844169	4	4	154	1	0	0	0	0	0	1	0	0	17489	1291	45	2	242	2	XAGE5	23	52844169	Nonsense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1355793	52844169	102426391	783	28630											
HUWE1	10075	broad.mit.edu	37	chrX	53571657	53571657	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atggacatagaaggcagctgGagctcccggccacccaaagg	12	4	13	12	1	0	1	0	0	0	1	1	3	1	3	3	5	2	3	3	5	3	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:53571657G>C	uc004dsp.2	-	72	11517	c.11115C>G	c.(11113-11115)CTC>CTG	p.L3705L	HUWE1_uc004dsn.2_Silent_p.L2513L|HUWE1_uc004dsq.1_Silent_p.L20L	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3705					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AAGGCAGCTGGAGCTCCCGGC	0.522													5	93					0	0	0	0	C	53571657	C	C	53571657	2	2	154	1	0	0	0	0	0	0	0	1	7500	1161	41	2		2	HUWE1	23	53571657	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	727488	53571657	101698903	784	28631											
FGD1	2245	broad.mit.edu	37	chrX	54472808	54472808	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgcctcgggcggtcccacctCgaagccaatgaggggcaggc	7	5	15	14	3	0	1	0	1	0	0	3	2	1	1	4	5	2	1	4	5	2	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:54472808C>G	uc004dtg.2	-	18	3354	c.2620G>C	c.(2620-2622)GAG>CAG	p.E874Q		NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	874	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GGTCCCACCTCGAAGCCAATG	0.652													4	40					0	0	0	0	G	54472808	G	G	54472808	3	3	154	1	0	0	0	0	1	0	0	0	5864	893	31	3	269	3	FGD1	23	54472808	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	901151	54472808	100797752	785	28632											
ITIH5L	347365	broad.mit.edu	37	chrX	54785154	54785154	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatcagtgtcctcatatatGcgccgggctattccccggtt	6	12	10	13	3	2	0	2	0	0	0	4	0	4	0	4	2	1	3	4	2	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:54785154G>T	uc004dtj.2	-	8	1383	c.1353C>A	c.(1351-1353)CGC>CGA	p.R451R		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	451	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CCTCATATATGCGCCGGGCTA	0.572													10	29					2.17888e-05	4.35775e-05	1	0	T	54785154	T	T	54785154	2	4	154	1	0	0	0	0	0	0	0	1	7947	1306	46	4		4	ITIH5L	23	54785154	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	312346	54785154	100485406	786	28633											
PAGE5	90737	broad.mit.edu	37	chrX	55248198	55248198	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcacacacacttacacccttAggtccagcagcccactgagg	11	6	8	16	0	0	1	0	1	0	0	1	1	1	1	3	2	3	2	3	2	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:55248198A>C	uc004duj.2	+	3	384	c.142_splice	c.e3-2	p.V48_splice	PAGE5_uc004duk.2_Splice_Site_p.V28_splice	NM_130467	NP_569734	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 isoform 1												0						TTACACCCTTAGGTCCAGCAG	0.393													7	11					0	0	0	0	C	55248198	C	C	55248198	5	2	154	1	0	0	0	0	0	0	1	0	11447	434	15	5	150	5	PAGE5	23	55248198	Splice_Site	SNP	A	TCGA-CR-7388-01A-11D-2012-08	463044	55248198	100022362	787	28634											
FAM123B	139285	broad.mit.edu	37	chrX	63412059	63412059	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atctggcaaggccatctcctCcccacctccttggtaggtca	7	10	8	16	0	3	0	1	0	2	0	6	0	5	0	6	4	0	2	6	4	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:63412059C>A	uc004dvo.2	-	2	1381	c.1108G>T	c.(1108-1110)GAG>TAG	p.E370*		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	370	Glu-rich.				Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GCCATCTCCTCCCCACCTCCT	0.373													16	110					4.7546e-09	1.03448e-08	1	0	A	63412059	A	A	63412059	4	1	154	1	0	0	0	0	0	1	0	0	5451	864	30	2	2303	2	FAM123B	23	63412059	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	8163861	63412059	91858501	788	28635											
DLG3	1741	broad.mit.edu	37	chrX	69719860	69719860	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatttaatgataacctctaTgggaccagcatccagtcagt	13	11	7	10	0	2	1	1	1	1	0	3	2	3	2	3	1	2	1	3	1	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:69719860T>C	uc004dyi.1	+	16	2434	c.2106T>C	c.(2104-2106)TAT>TAC	p.Y702Y	DLG3_uc004dyj.1_Silent_p.Y397Y|DLG3_uc011mpn.1_Silent_p.Y250Y	NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	702	Guanylate kinase-like.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)					ATAACCTCTATGGGACCAGCA	0.498													8	42					0	0	0	0	C	69719860	C	C	69719860	2	2	154	1	0	0	0	0	0	0	0	1	4578	1471	51	5		5	DLG3	23	69719860	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	6307801	69719860	85550700	789	28636											
OGT	8473	broad.mit.edu	37	chrX	70776893	70776893	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccttgcagtgttatacgCgtgccatccaaattaatcct	10	12	8	11	2	0	0	0	0	0	0	2	1	2	0	4	0	4	2	4	0	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:70776893C>G	uc004eaa.1	+	10	1475	c.1258C>G	c.(1258-1260)CGT>GGT	p.R420G	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.R410G|OGT_uc004eac.2_Missense_Mutation_p.R281G|OGT_uc004ead.2_Missense_Mutation_p.R39G	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	420	TPR 11.				cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					GTGTTATACGCGTGCCATCCA	0.408													4	46					0	0	0	0	G	70776893	G	G	70776893	3	3	154	1	0	0	0	0	1	0	0	0	10901	768	27	3	1296	3	OGT	23	70776893	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1057033	70776893	84493667	790	28637											
NHSL2	340527	broad.mit.edu	37	chrX	71359607	71359607	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaccctgggccacttacccCctccaagcagcagtgtccgg	7	7	10	17	1	0	1	0	1	0	0	2	1	2	1	6	2	3	2	6	2	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:71359607C>A	uc011mqa.1	+	6	2209	c.2209C>A	c.(2209-2211)CCT>ACT	p.P737T	NHSL2_uc004eak.1_Missense_Mutation_p.P371T|NHSL2_uc010nli.2_Missense_Mutation_p.P506T	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	737											0	Renal(35;0.156)					CCACTTACCCCCTCCAAGCAG	0.577													6	63					8.12818e-05	0.000159302	1	0	A	71359607	A	A	71359607	3	1	154	1	0	0	0	0	1	0	0	0	10466	623	22	4	2231	4	NHSL2	23	71359607	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	582714	71359607	83910953	791	28638											
FLJ44635	392490	broad.mit.edu	37	chrX	71379782	71379782	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttgcagacgggctgcgcctgGaggtggaagggaagatagtc	9	7	18	7	2	0	2	0	0	0	2	1	5	0	5	1	5	2	2	1	5	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:71379782G>A	uc004eal.1	+	2	451	c.103G>A	c.(103-105)GAG>AAG	p.E35K		NM_207422	NP_997305	Q56UQ5	TPT1L_HUMAN	hypothetical protein LOC392490	35										lung(1)	1	Renal(35;0.156)					GCTGCGCCTGGAGGTGGAAGG	0.512													9	37					0	0	0	0	A	71379782	A	A	71379782	3	1	154	1	0	0	0	0	1	0	0	0	5963	1175	41	2	109	2	FLJ44635	23	71379782	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	20175	71379782	83890778	792	28639											
RLIM	51132	broad.mit.edu	37	chrX	73812474	73812474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaggtgacctacttctttCagctcttgctctggttctcc	5	15	8	13	0	5	2	1	1	4	1	6	2	5	2	2	2	3	3	2	2	1	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:73812474C>T	uc004ebu.2	-	5	966	c.676G>A	c.(676-678)GAA>AAA	p.E226K	RLIM_uc004ebw.2_Missense_Mutation_p.E226K	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	226					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CTACTTCTTTCAGCTCTTGCT	0.468													13	122					0	0	0	0	T	73812474	T	T	73812474	3	4	154	1	0	0	0	0	1	0	0	0	13455	835	29	2	1202	2	RLIM	23	73812474	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2432692	73812474	81458086	793	28640											
ATRX	546	broad.mit.edu	37	chrX	76854951	76854951	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccttcaccacctccccgaGatcttgaattccagacctta	9	12	4	16	1	2	3	1	1	1	2	5	4	5	3	7	0	0	0	7	0	2	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:76854951G>A	uc004ecp.3	-	25	6117	c.5885C>T	c.(5884-5886)TCT>TTT	p.S1962F	ATRX_uc004ecq.3_Missense_Mutation_p.S1924F|ATRX_uc004eco.3_Missense_Mutation_p.S1747F	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1962					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ACCTCCCCGAGATCTTGAATT	0.383			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						39	425					0	0	0	0	A	76854951	A	A	76854951	3	1	154	1	0	0	0	0	1	0	0	0	1210	942	33	2	1637	2	ATRX	23	76854951	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3042477	76854951	78415609	794	28641											
ATRX	546	broad.mit.edu	37	chrX	76938634	76938634	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggattatctatagcactgTcagaagaattacgcttatcc	13	13	7	8	1	2	2	1	0	1	2	3	3	3	3	1	1	2	2	1	1	8	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:76938634T>C	uc004ecp.3	-	9	2346	c.2114A>G	c.(2113-2115)GAC>GGC	p.D705G	ATRX_uc004ecq.3_Missense_Mutation_p.D667G|ATRX_uc004eco.3_Missense_Mutation_p.D490G|ATRX_uc004ecr.2_Missense_Mutation_p.D637G|ATRX_uc010nlx.1_Missense_Mutation_p.D676G|ATRX_uc010nly.1_Missense_Mutation_p.D650G	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	705					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TATAGCACTGTCAGAAGAATT	0.343			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						33	258					0	0	0	0	C	76938634	C	C	76938634	3	2	154	1	0	0	0	0	1	0	0	0	1210	1667	58	5	5472	5	ATRX	23	76938634	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	83683	76938634	78331926	795	28642											
ATP7A	538	broad.mit.edu	37	chrX	77271303	77271303	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggagatatcattaaagtaGttccaggaggcaaatttcca	14	11	10	6	0	1	1	1	0	0	1	3	3	3	2	2	3	0	3	2	3	5	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:77271303G>T	uc004ecx.3	+	12	2711	c.2551G>T	c.(2551-2553)GTT>TTT	p.V851F		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	851	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						CATTAAAGTAGTTCCAGGAGG	0.393													13	159					9.31168e-06	1.8816e-05	1	0	T	77271303	T	T	77271303	3	4	154	1	0	0	0	0	1	0	0	0	1192	1029	36	4	2593	4	ATP7A	23	77271303	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	332669	77271303	77999257	796	28643											
LPAR4	2846	broad.mit.edu	37	chrX	78010699	78010699	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccttttggtgacaccctctgCaagatctctggaactgcatt	8	13	8	12	0	2	2	0	1	2	1	3	3	2	3	2	2	3	2	2	2	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:78010699C>A	uc010nme.2	+	2	738	c.333C>A	c.(331-333)TGC>TGA	p.C111*		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	111	Extracellular (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						ACACCCTCTGCAAGATCTCTG	0.428													34	109					9.78485e-24	2.41259e-23	1	0	A	78010699	A	A	78010699	4	1	154	1	0	0	0	0	0	1	0	0	8957	718	25	4	335	4	LPAR4	23	78010699	Nonsense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	739396	78010699	77259861	797	28644											
P2RY10	27334	broad.mit.edu	37	chrX	78216597	78216597	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaagcaaatgaatgcagttGcgttggtcgggatgattaca	13	10	12	6	2	0	2	0	2	0	0	1	3	0	3	0	2	4	4	0	2	4	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:78216597G>T	uc004ede.2	+	4	949	c.580G>T	c.(580-582)GCG>TCG	p.A194S	P2RY10_uc004edf.2_Missense_Mutation_p.A194S	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	194	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.A194T(1)		ovary(2)|lung(2)|breast(1)	5						GAATGCAGTTGCGTTGGTCGG	0.458													6	66					1.06961e-07	2.26552e-07	1	0	T	78216597	T	T	78216597	3	4	154	1	0	0	0	0	1	0	0	0	11401	1319	46	4	582	4	P2RY10	23	78216597	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	205898	78216597	77053963	798	28645											
POU3F4	5456	broad.mit.edu	37	chrX	82763401	82763401	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctagtccatgcggactctgcGggcatgcagcaggggagtcc	7	7	15	12	2	1	0	0	0	1	0	3	2	3	2	2	4	4	3	2	4	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:82763401G>A	uc004eeg.2	+	1	133	c.69G>A	c.(67-69)GCG>GCA	p.A23A		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	23					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CGGACTCTGCGGGCATGCAGC	0.552													5	34					0	0	0	0	A	82763401	A	A	82763401	2	1	154	1	0	0	0	0	0	0	0	1	12332	1103	39	1		1	POU3F4	23	82763401	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	4546804	82763401	72507159	799	28646											
SATL1	340562	broad.mit.edu	37	chrX	84362472	84362472	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgactcaggcctggttggctCagcactaattggttcaggtc	7	12	12	10	0	3	1	3	1	0	0	4	1	3	1	1	5	1	4	1	5	1	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:84362472C>T	uc011mqx.1	-	1	1503	c.1503G>A	c.(1501-1503)CTG>CTA	p.L501L	SATL1_uc004een.2_Silent_p.L501L	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	314	Gln-rich.						N-acetyltransferase activity			breast(2)	2						CTGGTTGGCTCAGCACTAATT	0.547													9	81					0	0	0	0	T	84362472	T	T	84362472	2	4	154	1	0	0	0	0	0	0	0	1	13920	813	29	2		2	SATL1	23	84362472	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1599071	84362472	70908088	800	28647											
PCDH11X	27328	broad.mit.edu	37	chrX	91134149	91134149	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caagaactgcctctcgataaCacctttgtggcctgtgactc	9	11	8	13	1	1	2	0	1	1	1	3	3	1	2	3	1	3	0	3	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:91134149C>A	uc004efk.1	+	2	3755	c.2910C>A	c.(2908-2910)AAC>AAA	p.N970K	PCDH11X_uc004efl.1_Missense_Mutation_p.N970K|PCDH11X_uc004efo.1_Missense_Mutation_p.N970K|PCDH11X_uc010nmv.1_Missense_Mutation_p.N970K|PCDH11X_uc004efm.1_Missense_Mutation_p.N970K|PCDH11X_uc004efn.1_Missense_Mutation_p.N970K|PCDH11X_uc004efh.1_Missense_Mutation_p.N970K|PCDH11X_uc004efj.1_Missense_Mutation_p.N970K	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	970	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTCTCGATAACACCTTTGTGG	0.502													50	154					4.86159e-25	1.20716e-24	1	0	A	91134149	A	A	91134149	3	1	154	1	0	0	0	0	1	0	0	0	11562	477	17	4	2916	4	PCDH11X	23	91134149	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	6771677	91134149	64136411	801	28648											
BTK	695	broad.mit.edu	37	chrX	100608907	100608907	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacttgctatacatcaggacTtccggtggggaccaccggac	10	8	11	12	2	1	0	1	0	0	0	2	3	2	3	3	5	3	1	3	5	3	4	rs146681416	byFrequency	TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:100608907T>A	uc004ehg.2	-	17	1894	c.1701A>T	c.(1699-1701)GAA>GAT	p.E567D	BTK_uc004ehf.2_Missense_Mutation_p.E67D|BTK_uc010nnh.2_Intron|BTK_uc010nni.2_Intron|BTK_uc004ehe.2_RNA|BTK_uc010nnj.2_RNA|BTK_uc010nnk.2_RNA|BTK_uc010nnl.2_Missense_Mutation_p.E43D|BTK_uc010nnm.2_Missense_Mutation_p.E137D|BTK_uc010nnn.2_Missense_Mutation_p.E391D|BTK_uc010nno.2_Missense_Mutation_p.E601D|BTK_uc004ehh.1_RNA	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	567	Protein kinase.		E -> K (in XLA; severe).		calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						ACATCAGGACTTCCGGTGGGG	0.443									Agammaglobulinemia_X-linked				6	93					0	0	0	0	A	100608907	A	A	100608907	3	1	154	1	0	0	0	0	1	0	0	0	1562	1606	56	5	290	5	BTK	23	100608907	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	9474758	100608907	54661653	802	28649											
TCEAL2	140597	broad.mit.edu	37	chrX	101381993	101381993	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttaaaggataaagaaaagcCagagagtgcgggaaaggcaa	19	4	14	4	1	0	2	0	0	0	2	0	5	0	4	1	3	2	2	1	3	8	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:101381993C>T	uc004eip.2	+	3	410	c.191C>T	c.(190-192)CCA>CTA	p.P64L		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	64					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AAAGAAAAGCCagagagtgcg	0.209													8	16					0	0	0	0	T	101381993	T	T	101381993	3	4	154	1	0	0	0	0	1	0	0	0	15737	594	21	4	193	4	TCEAL2	23	101381993	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	773086	101381993	53888567	803	28650											
ARMCX5	64860	broad.mit.edu	37	chrX	101857875	101857875	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctttgaccaagatcccacCttatcatgggccttattacc	10	12	5	14	0	1	2	1	1	0	1	2	2	2	2	6	1	1	0	6	1	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:101857875C>T	uc004ejg.2	+	6	1687	c.806C>T	c.(805-807)CCT>CTT	p.P269L	ARMCX5_uc004ejh.2_Missense_Mutation_p.P269L	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	269							binding			ovary(1)	1						AAGATCCCACCTTATCATGGG	0.488													10	119					0	0	0	0	T	101857875	T	T	101857875	3	4	154	1	0	0	0	0	1	0	0	0	964	681	24	4	808	4	ARMCX5	23	101857875	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	475882	101857875	53412685	804	28651											
GPRASP1	9737	broad.mit.edu	37	chrX	101910570	101910570	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggccaggagctgaagaaGagacaatattcgggtcctgg	12	6	14	9	1	0	3	0	1	0	2	2	5	1	4	3	4	1	1	3	4	4	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:101910570G>A	uc004ejj.3	+	5	2530	c.1729G>A	c.(1729-1731)GAG>AAG	p.E577K	GPRASP1_uc004eji.3_Missense_Mutation_p.E577K|GPRASP1_uc010nod.2_Missense_Mutation_p.E577K	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	577	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						AGCTGAAGAAGAGACAATATT	0.507													22	157					0	0	0	0	A	101910570	A	A	101910570	3	1	154	1	0	0	0	0	1	0	0	0	6761	943	33	2	1731	2	GPRASP1	23	101910570	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	52695	101910570	53359990	805	28652											
RAB40AL	282808	broad.mit.edu	37	chrX	102192824	102192824	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcaaggtactgagcttgcAagacctctgctgccgcacca	10	7	11	13	1	1	2	0	1	1	1	1	3	1	2	3	1	6	6	3	1	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:102192824A>G	uc004ejs.2	+	1	625	c.578A>G	c.(577-579)CAA>CGA	p.Q193R		NM_001031834	NP_001027004	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	193	SOCS box.				protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			ovary(2)	2						CTGAGCTTGCAAGACCTCTGC	0.567													21	46					0	0	0	0	G	102192824	G	G	102192824	3	3	154	1	0	0	0	0	1	0	0	0	13005	130	5	5	580	5	RAB40AL	23	102192824	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	282254	102192824	53077736	806	28653											
NGFRAP1	27018	broad.mit.edu	37	chrX	102632528	102632528	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagcctgcaggaaatcgaCggggacaggctcgccgactt	10	5	13	13	4	0	0	0	0	0	0	2	4	0	2	3	4	2	2	3	4	1	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:102632528C>A	uc004eki.2	+	3	491	c.109C>A	c.(109-111)CGG>AGG	p.R37R	NGFRAP1_uc004ekh.2_Silent_p.R27R|NGFRAP1_uc004ekj.1_Silent_p.R37R	NM_206915	NP_996798	Q00994	BEX3_HUMAN	nerve growth factor receptor (TNFRSF16)	37					apoptosis|multicellular organismal development|nerve growth factor receptor signaling pathway	cytosol|nucleus	caspase regulator activity|metal ion binding				0						AGGAAATCGACGGGGACAGGC	0.522													14	193					1.05317e-09	2.33183e-09	1	0	A	102632528	A	A	102632528	2	1	154	1	0	0	0	0	0	0	0	1	10451	527	19	3		3	NGFRAP1	23	102632528	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	439704	102632528	52638032	807	28654											
IL1RAPL2	26280	broad.mit.edu	37	chrX	105011308	105011308	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcggtgccatgttctggactCcgcagaacaaggactttttg	8	12	11	10	2	1	1	0	0	1	1	3	3	2	3	2	3	2	2	2	3	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:105011308C>G	uc004elz.1	+	11	2471	c.1715C>G	c.(1714-1716)TCC>TGC	p.S572C		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	572	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						GTTCTGGACTCCGCAGAACAA	0.438													12	101					0	0	0	0	G	105011308	G	G	105011308	3	3	154	1	0	0	0	0	1	0	0	0	7701	855	30	2	1753	2	IL1RAPL2	23	105011308	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	2378780	105011308	50259252	808	28655											
MID2	11043	broad.mit.edu	37	chrX	107148729	107148729	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttatgaaactgagaaagttgGcacagcaggttgctaattgc	13	11	11	6	0	0	2	0	2	0	1	0	3	0	2	0	2	4	5	0	2	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:107148729G>C	uc004enl.2	+	5	1519	c.946G>C	c.(946-948)GCA>CCA	p.A316P	MID2_uc004enk.2_Missense_Mutation_p.A316P	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	316						centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						GAGAAAGTTGGCACAGCAGGT	0.373													7	111					0	0	0	0	C	107148729	C	C	107148729	3	2	154	1	0	0	0	0	1	0	0	0	9631	1203	42	4	964	4	MID2	23	107148729	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2137421	107148729	48121831	809	28656											
COL4A5	1287	broad.mit.edu	37	chrX	107868952	107868952	+	Frame_Shift_Del	DEL	G	-	-																															taggtcccaaaggtaaccctGgtctccctggacagccaggt																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:107868952delG	uc004enz.1	+	35	3236	c.3034delG	c.(3034-3036)GGTfs	p.G1012fs	COL4A5_uc011mso.1_Frame_Shift_Del_p.G1012fs|COL4A5_uc004eob.1_Frame_Shift_Del_p.G620fs	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1012	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						AGGTAACCCTGGTCTCCCTGG	0.413									Alport_syndrome_with_Diffuse_Leiomyomatosis				---	---	---								-	107868952	-	-	107868952	7	5	154	1	0	1	0	1	0	0	0	0	3709	1348	47	0	3172	0	COL4A5	23	107868952	Frame_Shift_Del	DEL	G	TCGA-CR-7388-01A-11D-2012-08	720223	107868952	47401608	810	28657											
IRS4	8471	broad.mit.edu	37	chrX	107977922	107977922	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaccgtgcccacctgcggtGccctggccatctctagagca	7	7	11	16	2	1	1	0	0	1	1	2	2	1	1	5	2	5	1	5	2	2	1			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:107977922G>T	uc004eoc.2	-	1	1686	c.1653C>A	c.(1651-1653)GGC>GGA	p.G551G		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	551						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CACCTGCGGTGCCCTGGCCAT	0.642													15	164					0.00244969	0.00460595	1	0	T	107977922	T	T	107977922	2	4	154	1	0	0	0	0	0	0	0	1	7881	1306	46	4		4	IRS4	23	107977922	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	108970	107977922	47292638	811	28658											
IRS4	8471	broad.mit.edu	37	chrX	107978169	107978169	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctggggattgccttcctccCcaaagttgccagagccagaa	9	8	10	14	0	0	2	0	0	0	2	2	3	2	3	7	2	3	1	7	2	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:107978169C>A	uc004eoc.2	-	1	1439	c.1406G>T	c.(1405-1407)GGG>GTG	p.G469V		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	469						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GCCTTCCTCCCCAAAGTTGCC	0.582													14	119					1.5842e-08	3.40884e-08	1	0	A	107978169	A	A	107978169	3	1	154	1	0	0	0	0	1	0	0	0	7881	623	22	4	2371	4	IRS4	23	107978169	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	247	107978169	47292391	812	28659											
ACSL4	2182	broad.mit.edu	37	chrX	108921236	108921236	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctggtcagagagtgtaagcGgagaagaatatccaatcctg	13	8	12	8	1	1	3	1	0	0	3	3	5	3	3	3	2	1	1	3	2	5	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:108921236G>A	uc004eoi.2	-	9	1539	c.1034C>T	c.(1033-1035)CCG>CTG	p.P345L	ACSL4_uc004eoj.2_Missense_Mutation_p.P304L|ACSL4_uc004eok.2_Missense_Mutation_p.P304L|ACSL4_uc010npp.1_Missense_Mutation_p.P345L	NM_022977	NP_075266	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	345	Cytoplasmic (Potential).				fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(1)|lung(1)|ovary(1)	3					Icosapent(DB00159)|Troglitazone(DB00197)	GAGTGTAAGCGGAGAAGAATA	0.428													6	67					0	0	0	0	A	108921236	A	A	108921236	3	1	154	1	0	0	0	0	1	0	0	0	179	1116	39	1	1137	1	ACSL4	23	108921236	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	943067	108921236	46349324	813	28660											
AMOT	154796	broad.mit.edu	37	chrX	112025794	112025794	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccatgtcaaggcaacgcttAttggccatcaagatttcttc	10	13	7	11	1	3	1	2	0	1	1	5	1	4	1	2	2	1	2	2	2	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:112025794A>G	uc004epr.2	-	8	2214	c.2214T>C	c.(2212-2214)AAT>AAC	p.N738N	AMOT_uc004eps.2_Silent_p.N329N|AMOT_uc011mtc.1_5'Flank|hsa-mir-4329|MI0015901_5'Flank	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	738	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						GGCAACGCTTATTGGCCATCA	0.463													5	64					0	0	0	0	G	112025794	G	G	112025794	2	3	154	1	0	0	0	0	0	0	0	1	582	446	16	5		5	AMOT	23	112025794	Silent	SNP	A	TCGA-CR-7388-01A-11D-2012-08	3104558	112025794	43244766	814	28661											
AKAP14	158798	broad.mit.edu	37	chrX	119054534	119054534	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgatgccaaatatagtttCatggagtcattccccttctt	10	15	6	10	0	3	1	2	1	1	0	4	2	4	2	3	1	1	1	3	1	3	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:119054534C>T	uc004ese.2	+	7	696	c.558C>T	c.(556-558)TTC>TTT	p.F186F	AKAP14_uc004esf.2_Silent_p.F126F	NM_178813	NP_848928	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14 isoform a	186						cytoplasm					0						AATATAGTTTCATGGAGTCAT	0.353													9	53					0	0	0	0	T	119054534	T	T	119054534	2	4	154	1	0	0	0	0	0	0	0	1	450	825	29	2		2	AKAP14	23	119054534	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	7028740	119054534	36216026	815	28662											
GLUD2	2747	broad.mit.edu	37	chrX	120183197	120183197	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaagtgtacagtgaagcTggtgtgaccttcacatagat	12	12	10	7	0	2	3	2	2	0	1	2	3	2	3	1	1	2	2	1	1	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:120183197T>C	uc004eto.2	+	1	1736	c.1659T>C	c.(1657-1659)GCT>GCC	p.A553A		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	553					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	ACAGTGAAGCTGGTGTGACCT	0.433													20	108					0	0	0	0	C	120183197	C	C	120183197	2	2	154	1	0	0	0	0	0	0	0	1	6514	1567	55	5		5	GLUD2	23	120183197	Silent	SNP	T	TCGA-CR-7388-01A-11D-2012-08	1128663	120183197	35087363	816	28663											
SH2D1A	4068	broad.mit.edu	37	chrX	123504074	123504074	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggaaaataaaaaatctcAtttcagcatttcagaagcca	17	10	5	9	1	3	1	3	0	1	1	5	2	4	2	2	1	2	1	2	1	6	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:123504074A>T	uc004euf.3	+	3	595	c.250A>T	c.(250-252)ATT>TTT	p.I84F	SH2D1A_uc004euh.3_Missense_Mutation_p.I84F|SH2D1A_uc004eug.3_Intron|SH2D1A_uc010nqw.2_Intron|SH2D1A_uc004eui.3_RNA|SH2D1A_uc010nqx.2_Intron	NM_002351	NP_002342	O60880	SH21A_HUMAN	SH2 domain protein 1A isoform 1	84	SH2.		I -> T (in XLP1; reduced protein stability).		cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity				0						AAAAAATCTCATTTCAGCATT	0.368									X-linked_Lymphoproliferative_syndrome				15	107					0	0	0	0	T	123504074	T	T	123504074	3	4	154	1	0	0	0	0	1	0	0	0	14295	217	8	5	260	5	SH2D1A	23	123504074	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	3320877	123504074	31766486	817	28664											
ODZ1	10178	broad.mit.edu	37	chrX	123805604	123805604	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccatggactcggtccccCtgttccctttgctaactcca	5	13	7	16	1	0	0	0	0	0	0	5	1	4	1	5	2	2	2	5	2	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:123805604C>A	uc004euj.2	-	6	1161	c.1097G>T	c.(1096-1098)AGG>ATG	p.R366M	ODZ1_uc011muj.1_Missense_Mutation_p.R365M|ODZ1_uc010nqy.2_Missense_Mutation_p.R366M	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	366	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTCGGTCCCCCTGTTCCCTTT	0.438													27	169					1.5548e-18	3.77533e-18	1	0	A	123805604	A	A	123805604	3	1	154	1	0	0	0	0	1	0	0	0	10888	681	24	4	7209	4	ODZ1	23	123805604	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	301530	123805604	31464956	818	28665											
DCAF12L2	340578	broad.mit.edu	37	chrX	125299012	125299012	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtagggcagcctgatggacAggagcctggatagtgtgctc	9	8	16	8	0	0	1	0	1	0	0	1	4	0	4	2	4	3	3	2	4	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:125299012A>T	uc004euk.1	-	1	923	c.896T>A	c.(895-897)CTG>CAG	p.L299Q		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	299	WD 3.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CCTGATGGACAGGAGCCTGGA	0.612													22	107					0	0	0	0	T	125299012	T	T	125299012	3	4	154	1	0	0	0	0	1	0	0	0	4282	188	7	5	499	5	DCAF12L2	23	125299012	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	1493408	125299012	29971548	819	28666											
DCAF12L1	139170	broad.mit.edu	37	chrX	125685234	125685234	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcatagttcccatggaggCctgcagggagaggcccccca	8	6	13	14	0	0	1	0	0	0	1	1	3	1	2	5	4	2	3	5	4	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:125685234C>A	uc004eul.2	-	1	1609	c.1358G>T	c.(1357-1359)GGC>GTC	p.G453V		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	453										skin(3)|ovary(1)	4						CCCATGGAGGCCTGCAGGGAG	0.557													5	104					5.9392e-07	1.23857e-06	1	0	A	125685234	A	A	125685234	3	1	154	1	0	0	0	0	1	0	0	0	4281	739	26	4	37	4	DCAF12L1	23	125685234	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	386222	125685234	29585326	820	28667											
ACTRT1	139741	broad.mit.edu	37	chrX	127185739	127185739	+	Frame_Shift_Del	DEL	G	-	-																															accaccaggcctgtgacacaGgcagaggcatagagcgctgc																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:127185739delG	uc004eum.2	-	1	644	c.447delC	c.(445-447)GCCfs	p.A149fs		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	149						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						CTGTGACACAGGCAGAGGCAT	0.527													---	---	---								-	127185739	-	-	127185739	7	5	154	1	0	1	0	1	0	0	0	0	218	987	35	0	687	0	ACTRT1	23	127185739	Frame_Shift_Del	DEL	G	TCGA-CR-7388-01A-11D-2012-08	1500505	127185739	28084821	821	28668											
ENOX2	10495	broad.mit.edu	37	chrX	129759343	129759343	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccatctcttttccaggctgGctccaactccagtcatttcc	6	14	5	16	0	2	0	1	0	1	0	8	0	7	0	5	2	1	2	5	2	1	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:129759343G>T	uc004evw.2	-	16	2196	c.1778C>A	c.(1777-1779)GCC>GAC	p.A593D	ENOX2_uc004evx.2_Missense_Mutation_p.A564D|ENOX2_uc004evy.2_Missense_Mutation_p.A564D|ENOX2_uc004evv.2_Missense_Mutation_p.A418D	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	593					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						TTCCAGGCTGGCTCCAACTCC	0.478													6	76					2.7689e-08	5.93624e-08	1	0	T	129759343	T	T	129759343	3	4	154	1	0	0	0	0	1	0	0	0	5151	1203	42	4	58	4	ENOX2	23	129759343	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	2573604	129759343	25511217	822	28669											
IGSF1	3547	broad.mit.edu	37	chrX	130416528	130416528	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgtaggttacattgttgAggaagaatgatgtgttgtca	11	14	12	4	0	1	3	1	2	0	1	1	4	1	4	0	2	1	4	0	2	4	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:130416528A>T	uc004ewd.2	-	7	1374	c.1136T>A	c.(1135-1137)CTC>CAC	p.L379H	IGSF1_uc004ewe.3_Missense_Mutation_p.L368H|IGSF1_uc004ewf.2_Missense_Mutation_p.L359H	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	379	Ig-like C2-type 4.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						TACATTGTTGAGGAAGAATGA	0.453													12	48					0	0	0	0	T	130416528	T	T	130416528	3	4	154	1	0	0	0	0	1	0	0	0	7635	304	11	5	2945	5	IGSF1	23	130416528	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	657185	130416528	24854032	823	28670											
IGSF1	3547	broad.mit.edu	37	chrX	130417184	130417184	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acctgagattcaggctttctCcaggtgccatgatgggccca	8	10	11	12	0	2	2	1	2	1	1	3	3	2	2	4	3	1	1	4	3	0	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:130417184C>A	uc004ewd.2	-	6	960	c.722G>T	c.(721-723)GGA>GTA	p.G241V	IGSF1_uc004ewe.3_Missense_Mutation_p.G230V|IGSF1_uc004ewf.2_Missense_Mutation_p.G221V	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	241	Ig-like C2-type 3.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CAGGCTTTCTCCAGGTGCCAT	0.478													17	52					1.99824e-07	4.20706e-07	1	0	A	130417184	A	A	130417184	3	1	154	1	0	0	0	0	1	0	0	0	7635	855	30	2	3363	2	IGSF1	23	130417184	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	656	130417184	24853376	824	28671											
FRMD7	90167	broad.mit.edu	37	chrX	131228105	131228105	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataccatcaacgctgtacagTtgtcactgcatggaagcctt	11	11	8	11	1	2	0	2	0	0	0	2	1	2	1	2	1	5	4	2	1	4	4			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:131228105T>C	uc004ewn.2	-	5	525	c.347A>G	c.(346-348)AAC>AGC	p.N116S	FRMD7_uc011muy.1_Missense_Mutation_p.N101S	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	116	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					CGCTGTACAGTTGTCACTGCA	0.423													13	126					0	0	0	0	C	131228105	C	C	131228105	3	2	154	1	0	0	0	0	1	0	0	0	6089	1725	60	5	1829	5	FRMD7	23	131228105	Missense_Mutation	SNP	T	TCGA-CR-7388-01A-11D-2012-08	810921	131228105	24042455	825	28672											
USP26	83844	broad.mit.edu	37	chrX	132162111	132162111	+	Frame_Shift_Del	DEL	T	-	-																															cttagccgaaaagtgctataTtttccacttttgaaatacag																										TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:132162111delT	uc010nrm.1	-	6	608	c.138delA	c.(136-138)AAAfs	p.K46fs	USP26_uc011mvf.1_Frame_Shift_Del_p.K46fs	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	46					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					AAGTGCTATATTTTCCACTTT	0.333													---	---	---								-	132162111	-	-	132162111	7	5	154	1	0	1	0	1	0	0	0	0	17125	1490	52	0	2606	0	USP26	23	132162111	Frame_Shift_Del	DEL	T	TCGA-CR-7388-01A-11D-2012-08	934006	132162111	23108449	826	28673											
FAM122C	159091	broad.mit.edu	37	chrX	133979247	133979247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctttacaggaagaagccatgGatttaataaatagagaaaca	19	9	8	5	0	0	2	0	0	0	2	0	5	0	4	1	2	3	0	1	2	8	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:133979247G>A	uc004exz.1	+	4	664	c.259G>A	c.(259-261)GAT>AAT	p.D87N	FAM122C_uc011mvq.1_RNA|FAM122C_uc004exy.1_Missense_Mutation_p.D87N	NM_138819	NP_620174	Q6P4D5	F222C_HUMAN	hypothetical protein LOC159091	87											0	Acute lymphoblastic leukemia(192;0.000127)					AGAAGCCATGGATTTAATAAA	0.284													17	145					0	0	0	0	A	133979247	A	A	133979247	3	1	154	1	0	0	0	0	1	0	0	0	5449	1174	41	2	737	2	FAM122C	23	133979247	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1817136	133979247	21291313	827	28674											
DDX26B	203522	broad.mit.edu	37	chrX	134681181	134681181	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caggaccagatccacttcctAttggagaaggtatagtagat	13	10	10	8	0	0	3	0	0	0	3	2	5	2	4	3	3	0	2	3	3	5	6			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:134681181A>G	uc004eyw.3	+	6	1096	c.733A>G	c.(733-735)ATT>GTT	p.I245V		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	245											0	Acute lymphoblastic leukemia(192;6.56e-05)					TCCACTTCCTATTGGAGAAGG	0.308													8	133					0	0	0	0	G	134681181	G	G	134681181	3	3	154	1	0	0	0	0	1	0	0	0	4370	449	16	5	755	5	DDX26B	23	134681181	Missense_Mutation	SNP	A	TCGA-CR-7388-01A-11D-2012-08	701934	134681181	20589379	828	28675											
RBMX	27316	broad.mit.edu	37	chrX	135961278	135961278	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttcacggtctttcatcaaGagtactaaaaagtagttttc	12	15	7	7	1	4	1	3	0	1	1	5	1	4	1	0	1	1	4	0	1	6	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:135961278G>A	uc004fae.1	-	3	324	c.114C>T	c.(112-114)CTC>CTT	p.L38L	RBMX_uc011mwf.1_Silent_p.L38L|RBMX_uc004fad.1_Silent_p.L38L|RBMX_uc011mwg.1_5'UTR|RBMX_uc004faf.1_5'UTR|RBMX_uc010nsf.1_5'UTR|RBMX_uc004fag.1_Intron	NM_002139	NP_002130	P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked isoform 1	38	RRM.					catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					CTTTCATCAAGAGTACTAAAA	0.378													9	108					0	0	0	0	A	135961278	A	A	135961278	2	1	154	1	0	0	0	0	0	0	0	1	13216	929	33	2		2	RBMX	23	135961278	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1280097	135961278	19309282	829	28676											
SOX3	6658	broad.mit.edu	37	chrX	139586788	139586788	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccgcgggaccataccatGaaggcgttcatgggccgttt	7	9	13	12	4	1	1	1	1	0	0	1	2	1	2	4	3	2	2	4	3	2	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:139586788G>T	uc004fbd.1	-	1	438	c.438C>A	c.(436-438)TTC>TTA	p.F146L		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	146	HMG box.				face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					ACCATACCATGAAGGCGTTCA	0.662													18	34					0.00498961	0.00927244	1	0	T	139586788	T	T	139586788	3	4	154	1	0	0	0	0	1	0	0	0	15015	1281	45	2	906	2	SOX3	23	139586788	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	3625510	139586788	15683772	830	28677											
MAGEC3	139081	broad.mit.edu	37	chrX	140926157	140926157	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttcagtgatggcagtctagGccagtgggtgaaaaacacat	12	9	12	8	0	2	2	1	2	1	0	2	2	2	2	1	3	1	1	1	3	3	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:140926157G>T	uc011mwp.1	+	1	56	c.56G>T	c.(55-57)GGC>GTC	p.G19V		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	19										skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGCAGTCTAGGCCAGTGGGTG	0.502													18	63					4.96729e-08	1.05592e-07	1	0	T	140926157	T	T	140926157	3	4	154	1	0	0	0	0	1	0	0	0	9235	1203	42	4	58	4	MAGEC3	23	140926157	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	1339369	140926157	14344403	831	28678											
MAGEC1	9947	broad.mit.edu	37	chrX	140994191	140994191	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagtacttttgagggttttcCccagtctcttctccagattc	6	16	7	12	0	2	2	0	1	2	1	6	2	3	2	3	1	1	2	3	1	1	7			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:140994191C>A	uc004fbt.2	+	4	1287	c.1001C>A	c.(1000-1002)CCC>CAC	p.P334H	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	334							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GAGGGTTTTCCCCAGTCTCTT	0.463										HNSCC(15;0.026)			40	187					1.07121e-22	2.63382e-22	1	0	A	140994191	A	A	140994191	3	1	154	1	0	0	0	0	1	0	0	0	9233	623	22	4	1007	4	MAGEC1	23	140994191	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	68034	140994191	14276369	832	28679											
MAGEC2	51438	broad.mit.edu	37	chrX	141291018	141291018	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatacccctactgcattcagCacttcccagatgacctcctc	9	11	4	17	0	1	2	1	1	0	1	4	2	3	2	5	0	4	2	5	0	3	5			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:141291018C>A	uc004fbu.1	-	3	1104	c.756G>T	c.(754-756)GTG>GTT	p.V252V		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	252	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCATTCAGCACTTCCCAGA	0.517										HNSCC(46;0.14)			11	152					5.50884e-06	1.11573e-05	1	0	A	141291018	A	A	141291018	2	1	154	1	0	0	0	0	0	0	0	1	9234	697	25	4		4	MAGEC2	23	141291018	Silent	SNP	C	TCGA-CR-7388-01A-11D-2012-08	296827	141291018	13979542	833	28680											
MAGEA3	4102	broad.mit.edu	37	chrX	151935815	151935815	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atacttgaggagcagaaaatGaaccaactcggccaccttcc	14	7	8	12	1	0	3	0	2	0	1	2	4	1	4	4	2	4	1	4	2	5	3			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:151935815G>T	uc004fgp.2	-	3	561	c.352C>A	c.(352-354)CAT>AAT	p.H118N		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	118	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					AGCAGAAAATGAACCAACTCG	0.537													8	149					5.4927e-09	1.18918e-08	1	0	T	151935815	T	T	151935815	3	4	154	1	0	0	0	0	1	0	0	0	9218	1290	45	2	596	2	MAGEA3	23	151935815	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	10644797	151935815	3334745	834	28681											
L1CAM	3897	broad.mit.edu	37	chrX	153132810	153132810	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgggtgccaccctgactcaCctgcctcaggtgtgaccaca	7	8	11	15	0	2	2	2	2	0	0	2	2	2	2	5	2	2	0	5	2	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:153132810C>A	uc004fjb.2	-	16	2245	c.2137_splice	c.e16+1	p.A713_splice	L1CAM_uc004fjc.2_Splice_Site_p.A713_splice|L1CAM_uc010nuo.2_Splice_Site_p.A708_splice	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor						axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCTGACTCACCTGCCTCAGG	0.597													9	110					1.12685e-05	2.25627e-05	1	0	A	153132810	A	A	153132810	5	1	154	1	0	0	0	0	0	0	1	0	8628	521	18	4	1687	4	L1CAM	23	153132810	Splice_Site	SNP	C	TCGA-CR-7388-01A-11D-2012-08	1196995	153132810	2137750	835	28682											
L1CAM	3897	broad.mit.edu	37	chrX	153132824	153132824	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gactcacctgcctcaggtgtGaccacagtctcagagaccgg	9	7	11	14	1	3	2	3	1	1	1	4	4	3	2	4	2	1	0	4	2	0	0			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:153132824G>C	uc004fjb.2	-	16	2232	c.2124C>G	c.(2122-2124)GTC>GTG	p.V708V	L1CAM_uc004fjc.2_Silent_p.V708V|L1CAM_uc010nuo.2_Silent_p.V703V	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	708	Extracellular (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTCAGGTGTGACCACAGTCT	0.607													7	120					0	0	0	0	C	153132824	C	C	153132824	2	2	154	1	0	0	0	0	0	0	0	1	8628	1277	45	2		2	L1CAM	23	153132824	Silent	SNP	G	TCGA-CR-7388-01A-11D-2012-08	14	153132824	2137736	836	28683											
TKTL1	8277	broad.mit.edu	37	chrX	153539314	153539314	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgtgaaccgcctgggaCacagtggtgcattgcccgcc	7	9	13	12	2	0	2	0	2	0	0	0	3	0	3	4	2	3	1	4	2	1	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:153539314C>G	uc004fkg.2	+	4	664	c.478C>G	c.(478-480)CAC>GAC	p.H160D	TKTL1_uc011mzl.1_Missense_Mutation_p.H154D|TKTL1_uc011mzm.1_Intron|TKTL1_uc004fkh.2_Missense_Mutation_p.H104D	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	160					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCGCCTGGGACACAGTGGTGC	0.512													7	75					0	0	0	0	G	153539314	G	G	153539314	3	3	154	1	0	0	0	0	1	0	0	0	16001	478	17	4	492	4	TKTL1	23	153539314	Missense_Mutation	SNP	C	TCGA-CR-7388-01A-11D-2012-08	406490	153539314	1731246	837	28684											
DKC1	1736	broad.mit.edu	37	chrX	153997472	153997472	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacaatgcatgatgtgcttGatgctcagtggctgtatgat	9	14	12	6	0	1	4	1	4	0	0	1	4	1	4	0	1	3	5	0	1	2	2			TCGA-CR-7388-01A-11D-2012-08	TCGA-CR-7388-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3eddb2ad-6c75-4ae7-9d27-8ec0e7b4aa55	1092f9db-c4fe-4d73-90ec-c522795f24e3	g.chrX:153997472G>A	uc004fmm.2	+	9	1012	c.802G>A	c.(802-804)GAT>AAT	p.D268N	DKC1_uc010nvf.2_Missense_Mutation_p.D268N	NM_001363	NP_001354	O60832	DKC1_HUMAN	dyskerin isoform 1	268					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity				0	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGATGTGCTTGATGCTCAGTG	0.433									Congenital_Dyskeratosis				10	140					0	0	0	0	A	153997472	A	A	153997472	3	1	154	1	0	0	0	0	1	0	0	0	4564	1290	45	2	836	2	DKC1	23	153997472	Missense_Mutation	SNP	G	TCGA-CR-7388-01A-11D-2012-08	458158	153997472	1273088	838	28685											
CA6	765	broad.mit.edu	37	chr1	9009363	9009363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggccacagcactaccccGcctgtgggggccagagacag	9	4	13	15	1	0	1	0	0	0	1	0	2	0	1	5	3	2	1	5	3	1	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:9009363G>A	uc001apm.2	+	2	145	c.121G>A	c.(121-123)GCC>ACC	p.A41T	CA6_uc009vmn.2_Intron	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	41					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		GCACTACCCCGCCTGTGGGGG	0.597													10	27					0	0	0	0	A	9009363	A	A	9009363	3	1	155	1	0	0	0	0	1	0	0	0	2533	1087	38	1	127	1	CA6	1	9009363	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08		9009363	240241258	1	28686											
GPR3	2827	broad.mit.edu	37	chr1	27721213	27721213	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccttccgcaaccaggatgTgcagaaagtgctgtgggctg	8	8	14	11	2	0	1	0	0	0	1	1	2	1	2	3	2	3	4	3	2	2	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:27721213T>C	uc001bod.2	+	2	1006	c.911T>C	c.(910-912)GTG>GCG	p.V304A		NM_005281	NP_005272	P46089	GPR3_HUMAN	G protein-coupled receptor 3	304	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane				ovary(1)	1		Breast(348;1.53e-05)|Ovarian(437;0.0606)|all_lung(284;0.157)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.81e-26)|Colorectal(126;1.24e-08)|KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;4.45e-06)|Lung(427;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|LUSC - Lung squamous cell carcinoma(448;0.008)|READ - Rectum adenocarcinoma(331;0.0419)		AACCAGGATGTGCAGAAAGTG	0.547													16	226					0	0	0	0	C	27721213	C	C	27721213	3	2	155	1	0	0	0	0	1	0	0	0	6724	1696	59	5	913	5	GPR3	1	27721213	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	18711850	27721213	221529408	2	28687											
PTCH2	8643	broad.mit.edu	37	chr1	45293249	45293249	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acctcgtacagggagaagtaCctgagctgggcgctcaggaa	11	6	14	10	2	1	2	1	1	0	1	2	4	1	3	2	3	3	4	2	3	4	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:45293249C>G	uc010olf.1	-	15	2208	c.2196G>C	c.(2194-2196)AGG>AGC	p.R732S	PTCH2_uc010olg.1_Missense_Mutation_p.R430S	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	732	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					GGGAGAAGTACCTGAGCTGGG	0.637									Basal_Cell_Nevus_syndrome				9	63					0	0	0	0	G	45293249	G	G	45293249	3	3	155	1	0	0	0	0	1	0	0	0	12793	506	18	4	1467	4	PTCH2	1	45293249	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	17572036	45293249	203957372	3	28688											
CYP2J2	1573	broad.mit.edu	37	chr1	60377930	60377930	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaaagttccttagtgctgTcagagtgaaccttctttgct	9	14	8	10	0	2	2	1	1	1	1	3	2	3	2	3	0	3	3	3	0	3	4	rs55753213		TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:60377930T>C	uc001czq.2	-	3	432	c.427A>G	c.(427-429)ACA>GCA	p.T143A		NM_000775	NP_000766	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J,	143					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			ovary(1)	1	all_cancers(7;0.000396)					CTTAGTGCTGTCAGAGTGAAC	0.433													5	61					0	0	0	0	C	60377930	C	C	60377930	3	2	155	1	0	0	0	0	1	0	0	0	4189	1667	58	5	1109	5	CYP2J2	1	60377930	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	15084681	60377930	188872691	4	28689											
LRIG2	9860	broad.mit.edu	37	chr1	113636139	113636139	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacctcagctcaaatataatAtcagaaatcaagacatcttc	17	10	4	10	0	5	2	4	0	1	2	6	3	5	2	1	0	1	1	1	0	6	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:113636139A>T	uc001edf.1	+	4	666	c.468A>T	c.(466-468)ATA>ATT	p.I156I	LRIG2_uc009wgn.1_Silent_p.I53I	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	156	LRR 4.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		CAAATATAATATCAGAAATCA	0.333													7	31					0	0	0	0	T	113636139	T	T	113636139	2	4	155	1	0	0	0	0	0	0	0	1	8995	439	16	5		5	LRIG2	1	113636139	Silent	SNP	A	TCGA-CR-7389-01A-11D-2012-08	53258209	113636139	135614482	5	28690											
FLG	2312	broad.mit.edu	37	chr1	152282261	152282261	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgactacagatgaatcttGtctgcgcccagtgcctgagt	8	11	10	12	2	2	3	0	2	2	1	3	4	3	3	3	0	3	0	3	0	2	2	rs145738429		TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:152282261G>T	uc001ezu.1	-	3	5137	c.5101C>A	c.(5101-5103)CAA>AAA	p.Q1701K		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1701	Ser-rich.|Filaggrin 10.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATGAATCTTGTCTGCGCCCA	0.562									Ichthyosis				16	439					6.31663e-08	2.2785e-07	1	0	T	152282261	T	T	152282261	3	4	155	1	0	0	0	0	1	0	0	0	5954	1386	48	4	7088	4	FLG	1	152282261	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	38646122	152282261	96968360	6	28691											
SPTA1	6708	broad.mit.edu	37	chr1	158639216	158639216	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttgtaatcttcatcatcTgccaactttttcttcttgtt	7	20	3	11	0	6	0	2	0	4	0	6	0	6	0	2	0	2	2	2	0	2	8			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:158639216T>C	uc001fst.1	-	14	2014	c.1815A>G	c.(1813-1815)GCA>GCG	p.A605A		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	605	Spectrin 7.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTTCATCATCTGCCAACTTTT	0.363													16	269					0	0	0	0	C	158639216	C	C	158639216	2	2	155	1	0	0	0	0	0	0	0	1	15182	1567	55	5		5	SPTA1	1	158639216	Silent	SNP	T	TCGA-CR-7389-01A-11D-2012-08	6356955	158639216	90611405	7	28692											
DARC	2532	broad.mit.edu	37	chr1	159175972	159175972	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggatgaatatcctgtgggCctggtttattttctggtggc	5	16	13	7	0	1	1	0	1	1	0	2	2	2	2	2	5	0	1	2	5	3	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:159175972C>A	uc001fto.2	+	2	983	c.743C>A	c.(742-744)GCC>GAC	p.A248D	DARC_uc001ftp.3_Missense_Mutation_p.A250D	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	248	Helical; Name=6; (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					ATCCTGTGGGCCTGGTTTATT	0.537													16	134					2.23348e-06	7.99936e-06	1	0	A	159175972	A	A	159175972	3	1	155	1	0	0	0	0	1	0	0	0	4257	739	26	4	776	4	DARC	1	159175972	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	536756	159175972	90074649	8	28693											
SLC19A2	10560	broad.mit.edu	37	chr1	169439294	169439294	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggccctgtgtgtagttcAcaacttgaaaatagccacag	13	9	9	10	0	1	1	1	1	0	0	1	1	1	1	2	1	2	2	2	1	5	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:169439294A>G	uc001gge.3	-	3	1142	c.938T>C	c.(937-939)GTG>GCG	p.V313A	SLC19A2_uc001ggf.3_Missense_Mutation_p.V112A	NM_006996	NP_008927	O60779	S19A2_HUMAN	solute carrier family 19, member 2	313	Extracellular (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity				0	all_hematologic(923;0.208)					TGTGTAGTTCACAACTTGAAA	0.498													11	114					0	0	0	0	G	169439294	G	G	169439294	3	3	155	1	0	0	0	0	1	0	0	0	14494	159	6	5	571	5	SLC19A2	1	169439294	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	10263322	169439294	79811327	9	28694											
KCTD3	51133	broad.mit.edu	37	chr1	215777531	215777531	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctctggagcagtacgagTgattgtacaacacccagaga	13	7	12	9	1	1	2	0	1	1	1	1	6	1	3	1	1	5	4	1	1	3	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:215777531T>G	uc001hks.2	+	13	1490	c.1196T>G	c.(1195-1197)GTG>GGG	p.V399G	KCTD3_uc001hkt.2_Missense_Mutation_p.V399G|KCTD3_uc010pub.1_Missense_Mutation_p.V297G|KCTD3_uc009xdn.2_Missense_Mutation_p.V151G	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	399						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		GCAGTACGAGTGATTGTACAA	0.453													5	68					0	0	0	0	G	215777531	G	G	215777531	3	3	155	1	0	0	0	0	1	0	0	0	8149	1696	59	5	1246	5	KCTD3	1	215777531	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	46338237	215777531	33473090	10	28695											
RYR2	6262	broad.mit.edu	37	chr1	237659885	237659885	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtactatgaattgatggTggaccacacagagccctttg	11	11	11	8	0	0	3	0	2	0	1	0	4	0	4	2	3	2	1	2	3	3	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:237659885T>C	uc001hyl.1	+	20	2156	c.2036T>C	c.(2035-2037)GTG>GCG	p.V679A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	679	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAATTGATGGTGGACCACACA	0.493													4	79					0	0	0	0	C	237659885	C	C	237659885	3	2	155	1	0	0	0	0	1	0	0	0	13834	1696	59	5	2114	5	RYR2	1	237659885	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	21882354	237659885	11590736	11	28696											
RYR2	6262	broad.mit.edu	37	chr1	237993897	237993897	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacatggctttgaaacccAcactttacaggagcacaact	13	8	7	13	0	0	1	0	1	0	0	0	2	0	2	2	2	4	2	2	2	3	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr1:237993897A>G	uc001hyl.1	+	103	14843	c.14723A>G	c.(14722-14724)CAC>CGC	p.H4908R	RYR2_uc010pyb.1_Intron	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4908					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTGAAACCCACACTTTACAG	0.463													13	134					0	0	0	0	G	237993897	G	G	237993897	3	3	155	1	0	0	0	0	1	0	0	0	13834	159	6	5	15133	5	RYR2	1	237993897	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	334012	237993897	11256724	12	28697											
MOGS	7841	broad.mit.edu	37	chr2	74688529	74688529	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtagcctggtactggcgcCatacattgcctaccacgttg	7	11	10	13	2	0	0	0	0	0	0	0	0	0	0	4	2	5	3	4	2	4	6			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr2:74688529C>T	uc010ffj.2	-	4	2550	c.2387G>A	c.(2386-2388)TGG>TAG	p.W796*	MOGS_uc010ffh.2_Nonsense_Mutation_p.W521*|MOGS_uc010yrt.1_Nonsense_Mutation_p.W677*|MOGS_uc010ffi.2_Nonsense_Mutation_p.W690*	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	796	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						GTACTGGCGCCATACATTGCC	0.622													10	80					0	0	0	0	T	74688529	T	T	74688529	4	4	155	1	0	0	0	0	0	1	0	0	9750	595	21	4	130	4	MOGS	2	74688529	Nonsense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08		74688529	168510844	13	28698											
FER1L5	90342	broad.mit.edu	37	chr2	97369275	97369275	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctagggcaaggtgaagatgAgcctggagattctgtcagag	11	8	15	7	0	2	5	1	2	1	3	2	6	2	5	2	3	1	1	2	3	3	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr2:97369275A>G	uc010fia.2	+	50	5815	c.5815A>G	c.(5815-5817)AGC>GGC	p.S1939G	FER1L5_uc002sws.3_Missense_Mutation_p.S648G|FER1L5_uc002swt.3_Missense_Mutation_p.S648G|FER1L5_uc010yus.1_Missense_Mutation_p.S647G	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1939						integral to membrane				ovary(1)	1						GGTGAAGATGAGCCTGGAGAT	0.572													12	32					0	0	0	0	G	97369275	G	G	97369275	3	3	155	1	0	0	0	0	1	0	0	0	5846	304	11	5	6013	5	FER1L5	2	97369275	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	22680746	97369275	145830098	14	28699											
GPR39	2863	broad.mit.edu	37	chr2	133403103	133403103	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccagtcattgagtctcgAgtcactagagcccaactcag	10	9	9	13	1	4	2	3	1	1	1	6	3	5	2	2	0	2	0	2	0	2	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr2:133403103A>T	uc002ttl.2	+	2	1755	c.1286A>T	c.(1285-1287)GAG>GTG	p.E429V	LYPD1_uc002ttm.3_3'UTR|LYPD1_uc002ttn.2_3'UTR|LYPD1_uc002tto.2_3'UTR	NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	429						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						TTGAGTCTCGAGTCACTAGAG	0.522													15	62					0	0	0	0	T	133403103	T	T	133403103	3	4	155	1	0	0	0	0	1	0	0	0	6731	304	11	5	1292	5	GPR39	2	133403103	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	36033828	133403103	109796270	15	28700											
TTN	7273	broad.mit.edu	37	chr2	179404536	179404536	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgtgtgtttcagatgtTgcaatcatggcacgcttact	8	15	10	8	1	3	1	3	0	0	1	3	1	3	1	0	1	2	5	0	1	2	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr2:179404536T>C	uc010zfg.1	-	301	90776	c.90552A>G	c.(90550-90552)GCA>GCG	p.A30184A	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.A23879A|TTN_uc010zfi.1_Silent_p.A23812A|TTN_uc010zfj.1_Silent_p.A23687A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31111							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCAGATGTTGCAATCATGG	0.443													4	72					0	0	0	0	C	179404536	C	C	179404536	2	2	155	1	0	0	0	0	0	0	0	1	16803	1799	63	5		5	TTN	2	179404536	Silent	SNP	T	TCGA-CR-7389-01A-11D-2012-08	46001433	179404536	63794837	16	28701											
SLC19A3	80704	broad.mit.edu	37	chr2	228552279	228552279	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttactgcaaaatagctcccaTaaactaaaaactggagaaaa	20	8	5	8	0	0	1	0	0	0	1	1	2	1	1	1	1	5	2	1	1	11	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr2:228552279T>C	uc002vpi.2	-	6	1414	c.1325A>G	c.(1324-1326)TAT>TGT	p.Y442C	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.Y438C	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	442	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	ATAGCTCCCATAAACTAAAAA	0.348													9	31					0	0	0	0	C	228552279	C	C	228552279	3	2	155	1	0	0	0	0	1	0	0	0	14495	1406	49	5	169	5	SLC19A3	2	228552279	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	49147743	228552279	14647094	17	28702											
PDCD1	5133	broad.mit.edu	37	chr2	242793393	242793393	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggggtcttctctcgccactgGaaatccagctccccatagtc	7	10	9	15	1	2	0	0	0	2	0	7	1	4	1	4	3	1	1	4	3	2	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr2:242793393G>A	uc002wcq.3	-	5	752	c.684C>T	c.(682-684)TTC>TTT	p.F228F	PDCD1_uc010fzs.2_Silent_p.F107F|PDCD1_uc010fzt.2_RNA	NM_005018	NP_005009	Q15116	PDCD1_HUMAN	programmed cell death 1 precursor	228	Cytoplasmic (Potential).				apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			ovary(1)	1		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		CTCGCCACTGGAAATCCAGCT	0.622													11	40					0	0	0	0	A	242793393	A	A	242793393	2	1	155	1	0	0	0	0	0	0	0	1	11669	1165	41	2		2	PDCD1	2	242793393	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	14241114	242793393	405980	18	28703											
ARPP21	10777	broad.mit.edu	37	chr3	35732405	35732405	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcgtatcagaggatgctTgtccatcgagtggcagctta	9	12	11	9	2	2	1	2	0	0	1	5	3	3	2	1	2	2	4	1	2	2	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr3:35732405T>A	uc003cgb.2	+	9	858	c.594T>A	c.(592-594)CTT>CTA	p.L198L	ARPP21_uc003cga.2_Silent_p.L198L|ARPP21_uc011axy.1_Silent_p.L198L|ARPP21_uc003cgf.2_Silent_p.L34L	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	198	R3H.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						AGAGGATGCTTGTCCATCGAG	0.383													7	54					0	0	0	0	A	35732405	A	A	35732405	2	1	155	1	0	0	0	0	0	0	0	1	980	1799	63	5		5	ARPP21	3	35732405	Silent	SNP	T	TCGA-CR-7389-01A-11D-2012-08		35732405	162290025	19	28704											
SCN11A	11280	broad.mit.edu	37	chr3	38936227	38936227	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccaggggaatgatgtcttTgctttgtgcagcacagcctc	8	11	12	10	0	1	1	0	1	1	0	2	3	1	2	2	2	4	3	2	2	1	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr3:38936227T>C	uc011ays.1	-	15	2831	c.2632A>G	c.(2632-2634)AAA>GAA	p.K878E	SCN11A_uc010hhn.1_5'UTR	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	878					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ATGATGTCTTTGCTTTGTGCA	0.502													14	83					0	0	0	0	C	38936227	C	C	38936227	3	2	155	1	0	0	0	0	1	0	0	0	13978	1821	63	5	2791	5	SCN11A	3	38936227	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	3203822	38936227	159086203	20	28705											
ROBO1	6091	broad.mit.edu	37	chr3	78700882	78700882	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccttgggaaagctaatacCttttctgatacccgcgtagg	11	11	9	10	2	1	1	0	1	1	0	1	2	1	2	3	2	4	2	3	2	6	7			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr3:78700882C>T	uc003dqe.2	-	19	3020	c.2812G>A	c.(2812-2814)GTC>ATC	p.V938I	ROBO1_uc003dqb.2_Missense_Mutation_p.V899I|ROBO1_uc003dqc.2_Missense_Mutation_p.V902I|ROBO1_uc003dqd.2_Missense_Mutation_p.V902I|ROBO1_uc010hoh.2_Missense_Mutation_p.V130I|ROBO1_uc011bgl.1_Missense_Mutation_p.V510I	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	938	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AAGCTAATACCTTTTCTGATA	0.363													9	25					0	0	0	0	T	78700882	T	T	78700882	3	4	155	1	0	0	0	0	1	0	0	0	13578	695	24	4	2195	4	ROBO1	3	78700882	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	39764655	78700882	119321548	21	28706											
ABI3BP	25890	broad.mit.edu	37	chr3	100489651	100489651	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatgaggggcacccttccacGgtgaccacagtgaggttggt	9	8	14	10	1	0	3	0	3	0	0	1	3	1	3	3	5	0	2	3	5	1	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr3:100489651G>A	uc003dun.2	-	29	2629	c.2544C>T	c.(2542-2544)ACC>ACT	p.T848T	ABI3BP_uc003duj.2_Silent_p.T428T|ABI3BP_uc003duk.2_Silent_p.T557T|ABI3BP_uc003dul.2_Silent_p.T678T|ABI3BP_uc011bhd.1_Silent_p.T802T|ABI3BP_uc003dum.2_Silent_p.T259T	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	848	Fibronectin type-III 2.					extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						ACCCTTCCACGGTGACCACAG	0.537													18	139					0	0	0	0	A	100489651	A	A	100489651	2	1	155	1	0	0	0	0	0	0	0	1	91	1103	39	1		1	ABI3BP	3	100489651	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	21788769	100489651	97532779	22	28707											
TIGIT	201633	broad.mit.edu	37	chr3	114014456	114014456	+	Frame_Shift_Del	DEL	C	-	-																															gagaaaggtggctctatcatCttacaatgtcacctctcctc																										TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr3:114014456delC	uc003ebg.1	+	2	160	c.126delC	c.(124-126)ATCfs	p.I42fs		NM_173799	NP_776160	Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	42	Extracellular (Potential).|Ig-like V-type.				negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)	1						GCTCTATCATCTTACAATGTC	0.522													---	---	---								-	114014456	-	-	114014456	7	5	155	1	0	1	0	1	0	0	0	0	15968	903	32	0	132	0	TIGIT	3	114014456	Frame_Shift_Del	DEL	C	TCGA-CR-7389-01A-11D-2012-08	13524805	114014456	84007974	23	28708											
SI	6476	broad.mit.edu	37	chr3	164758751	164758751	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagaactggtcttgctacTgtttctccaaacacatgggc	10	12	9	10	0	2	2	0	1	2	1	3	2	2	2	1	2	4	2	1	2	4	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr3:164758751T>G	uc003fei.2	-	18	2198	c.2136A>C	c.(2134-2136)ACA>ACC	p.T712T		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	712	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTCTTGCTACTGTTTCTCCAA	0.338										HNSCC(35;0.089)			6	129					0	0	0	0	G	164758751	G	G	164758751	2	3	155	1	0	0	0	0	0	0	0	1	14362	1567	55	5		5	SI	3	164758751	Silent	SNP	T	TCGA-CR-7389-01A-11D-2012-08	50744295	164758751	33263679	24	28709											
IDUA	3425	broad.mit.edu	37	chr4	995285	995285	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactggcgcatgtttccaagTggaacttcgagacgtggaat	10	10	13	8	3	0	1	0	0	0	1	2	5	1	3	1	3	1	2	1	3	3	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr4:995285T>C	uc003gby.2	+	5	611	c.523T>C	c.(523-525)TGG>CGG	p.W175R	IDUA_uc003gbz.2_RNA|IDUA_uc003gca.2_Missense_Mutation_p.W128R	NM_000203	NP_000194	P35475	IDUA_HUMAN	alpha-L-iduronidase precursor	175					disaccharide metabolic process	lysosome	cation binding|L-iduronidase activity				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)		Laronidase(DB00090)	TGTTTCCAAGTGGAACTTCGA	0.602													20	80					0	0	0	0	C	995285	C	C	995285	3	2	155	1	0	0	0	0	1	0	0	0	7543	1696	59	5	541	5	IDUA	4	995285	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08		995285	190158991	25	28710											
FRYL	285527	broad.mit.edu	37	chr4	48523117	48523117	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcctccaaagttggggtcTcatccctgatttgaagcact	10	11	9	11	0	1	2	1	2	1	0	4	2	3	2	3	2	2	2	3	2	3	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr4:48523117T>C	uc003gyh.1	-	55	8242	c.7637A>G	c.(7636-7638)GAG>GGG	p.E2546G	FRYL_uc003gyf.1_5'Flank|FRYL_uc003gyg.1_Missense_Mutation_p.E1242G|FRYL_uc003gyi.1_Missense_Mutation_p.E1434G|FRYL_uc003gyj.1_Missense_Mutation_p.E841G	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2546					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AGTTGGGGTCTCATCCCTGAT	0.502													7	69					0	0	0	0	C	48523117	C	C	48523117	3	2	155	1	0	0	0	0	1	0	0	0	6098	1551	54	5	1444	5	FRYL	4	48523117	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	47527832	48523117	142631159	26	28711											
EPHA5	2044	broad.mit.edu	37	chr4	66270095	66270095	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acagcttcctctcttaccttCcactgaggaggacgccgata	9	10	8	14	2	1	1	0	1	1	0	4	4	3	3	4	2	2	1	4	2	2	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr4:66270095C>T	uc003hcy.2	-	8	1980	c.1787G>A	c.(1786-1788)GGA>GAA	p.G596E	EPHA5_uc003hcx.2_Missense_Mutation_p.G528E|EPHA5_uc003hcz.2_Missense_Mutation_p.G596E|EPHA5_uc011cah.1_Missense_Mutation_p.G597E|EPHA5_uc011cai.1_Missense_Mutation_p.G597E|EPHA5_uc003hda.2_Missense_Mutation_p.G597E	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	596	Cytoplasmic (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CTCTTACCTTCCACTGAGGAG	0.483										TSP Lung(17;0.13)			5	31					0	0	0	0	T	66270095	T	T	66270095	3	4	155	1	0	0	0	0	1	0	0	0	5194	855	30	2	1370	2	EPHA5	4	66270095	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	17746978	66270095	124884181	27	28712											
SLC4A4	8671	broad.mit.edu	37	chr4	72215646	72215646	+	Frame_Shift_Del	DEL	A	-	-																															taggtggatcaagtttgaagAaaaagtggaacagggtgggg																										TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr4:72215646delA	uc003hfy.2	+	5	524	c.407delA	c.(406-408)GAAfs	p.E136fs	SLC4A4_uc010iic.2_Frame_Shift_Del_p.E136fs|SLC4A4_uc010iib.2_Frame_Shift_Del_p.E136fs|SLC4A4_uc003hfz.2_Frame_Shift_Del_p.E136fs|SLC4A4_uc003hgc.3_Frame_Shift_Del_p.E92fs|SLC4A4_uc003hga.2_Frame_Shift_Del_p.E14fs|SLC4A4_uc003hgb.3_Frame_Shift_Del_p.E92fs	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	136	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AAGTTTGAAGAAAAAGTGGAA	0.438													---	---	---								-	72215646	-	-	72215646	7	5	155	1	0	1	0	1	0	0	0	0	14720	246	9	0	542	0	SLC4A4	4	72215646	Frame_Shift_Del	DEL	A	TCGA-CR-7389-01A-11D-2012-08	5945551	72215646	118938630	28	28713											
FRAS1	80144	broad.mit.edu	37	chr4	79460498	79460498	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttccatgatgtgcctttTgaggctcactttgcctctga	6	16	8	11	0	2	3	1	3	1	0	3	3	3	3	3	1	3	1	3	1	1	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr4:79460498T>A	uc003hlb.2	+	73	11789	c.11349T>A	c.(11347-11349)TTT>TTA	p.F3783L		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3778	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ATGTGCCTTTTGAGGCTCACT	0.418													5	133					0	0	0	0	A	79460498	A	A	79460498	3	1	155	1	0	0	0	0	1	0	0	0	6076	1809	63	5	11714	5	FRAS1	4	79460498	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	7244852	79460498	111693778	29	28714											
ARHGAP10	79658	broad.mit.edu	37	chr4	148800393	148800393	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttgttgaagggcctgctccGtttggttccagttgggtcaa	5	15	13	8	1	1	1	1	1	0	0	3	1	3	1	3	3	1	5	3	3	2	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr4:148800393G>A	uc003ilf.2	+	9	843	c.843G>A	c.(841-843)CCG>CCA	p.P281P	ARHGAP10_uc003ilg.2_5'Flank	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	281	PH.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		GGCCTGCTCCGTTTGGTTCCA	0.388													9	66					0	0	0	0	A	148800393	A	A	148800393	2	1	155	1	0	0	0	0	0	0	0	1	862	1132	40	1		1	ARHGAP10	4	148800393	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	69339895	148800393	42353883	30	28715											
NPY2R	4887	broad.mit.edu	37	chr4	156136041	156136041	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccacatcatcgccatgtgctCcacttttgccaatccccttc	7	12	4	18	1	1	0	1	0	0	0	5	0	3	0	6	0	2	1	6	0	1	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr4:156136041C>T	uc003ioq.2	+	2	1445	c.950C>T	c.(949-951)TCC>TTC	p.S317F	NPY2R_uc003ior.2_Missense_Mutation_p.S317F	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	317	Helical; Name=7; (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				GCCATGTGCTCCACTTTTGCC	0.527													34	57					0	0	0	0	T	156136041	T	T	156136041	3	4	155	1	0	0	0	0	1	0	0	0	10663	855	30	2	952	2	NPY2R	4	156136041	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	7335648	156136041	35018235	31	28716											
TPPP	11076	broad.mit.edu	37	chr5	665268	665268	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgcctgcgtgcttgtagccGgacacatagcctgactcgtc	6	10	12	13	3	0	1	0	1	0	0	2	2	0	2	3	1	5	2	3	1	2	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:665268G>A	uc003jbg.3	-	3	1327	c.609C>T	c.(607-609)TCC>TCT	p.S203S	TPPP_uc003jbh.3_Silent_p.S203S	NM_007030	NP_008961	O94811	TPPP_HUMAN	tubulin polymerization promoting protein	203					microtubule bundle formation|microtubule polymerization|positive regulation of protein polymerization	nucleus|perinuclear region of cytoplasm|soluble fraction	calcium ion binding|microtubule binding				0		Ovarian(839;0.0563)	Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)	GBM - Glioblastoma multiforme(108;0.0191)		GCTTGTAGCCGGACACATAGC	0.657													4	151					0	0	0	0	A	665268	A	A	665268	2	1	155	1	0	0	0	0	0	0	0	1	16480	1103	39	1		1	TPPP	5	665268	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08		665268	180249992	32	28717											
DNAH5	1767	broad.mit.edu	37	chr5	13841092	13841092	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactcgttccgtggaactcaGatccctcgtggtgacgtcta	7	11	10	13	4	2	2	1	1	1	1	6	3	4	3	2	2	1	1	2	2	2	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:13841092G>A	uc003jfd.2	-	34	5674	c.5632C>T	c.(5632-5634)CTG>TTG	p.L1878L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1878	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GTGGAACTCAGATCCCTCGTG	0.398									Kartagener_syndrome				14	194					0	0	0	0	A	13841092	A	A	13841092	2	1	155	1	0	0	0	0	0	0	0	1	4626	933	33	2		2	DNAH5	5	13841092	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	13175824	13841092	167074168	33	28718											
WDR70	55100	broad.mit.edu	37	chr5	37480070	37480070	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaggagaccagtatattgTggacatggccaacaccaagg	16	6	11	8	0	0	1	0	0	0	1	0	3	0	2	3	4	1	1	3	4	6	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:37480070T>C	uc003jkv.2	+	8	879	c.821T>C	c.(820-822)GTG>GCG	p.V274A	WDR70_uc010iva.1_Missense_Mutation_p.V274A	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	274										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAGTATATTGTGGACATGGCC	0.318													4	140					0	0	0	0	C	37480070	C	C	37480070	3	2	155	1	0	0	0	0	1	0	0	0	17389	1696	59	5	851	5	WDR70	5	37480070	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	23638978	37480070	143435190	34	28719											
PTGER4	5734	broad.mit.edu	37	chr5	40681848	40681848	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccccagccttgccgcgcctCagcgactttcggcgccgccg	3	7	11	20	7	1	0	1	0	0	0	3	1	2	0	7	1	3	0	7	1	0	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:40681848C>G	uc003jlz.2	+	2	1345	c.753C>G	c.(751-753)CTC>CTG	p.L251L		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	251	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						TGCCGCGCCTCAGCGACTTTC	0.721													3	58					0	0	0	0	G	40681848	G	G	40681848	2	3	155	1	0	0	0	0	0	0	0	1	12808	813	29	2		2	PTGER4	5	40681848	Silent	SNP	C	TCGA-CR-7389-01A-11D-2012-08	3201778	40681848	140233412	35	28720											
C6	729	broad.mit.edu	37	chr5	41159295	41159295	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attctcgggttctcgatctcTtataagtagcatcacaggta	10	14	8	9	2	4	0	1	0	3	0	7	1	4	0	0	2	1	4	0	2	4	6			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:41159295T>C	uc003jmk.2	-	12	1955	c.1745A>G	c.(1744-1746)AAG>AGG	p.K582R	C6_uc003jml.1_Missense_Mutation_p.K582R	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	582	TSP type-1 3.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TCTCGATCTCTTATAAGTAGC	0.507													85	71					0	0	0	0	C	41159295	C	C	41159295	3	2	155	1	0	0	0	0	1	0	0	0	2325	1609	56	5	1087	5	C6	5	41159295	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	477447	41159295	139755965	36	28721											
MAP1B	4131	broad.mit.edu	37	chr5	71493969	71493969	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttcagtgtctgttgtgcAaacacctaccacattccagg	9	12	7	13	0	2	0	1	0	1	0	3	0	3	0	4	1	3	2	4	1	2	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:71493969A>G	uc003kbw.3	+	5	5028	c.4787A>G	c.(4786-4788)CAA>CGA	p.Q1596R	MAP1B_uc010iyw.1_Missense_Mutation_p.Q1613R|MAP1B_uc010iyx.1_Missense_Mutation_p.Q1470R|MAP1B_uc010iyy.1_Missense_Mutation_p.Q1470R	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1596						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TCTGTTGTGCAAACACCTACC	0.468													15	94					0	0	0	0	G	71493969	G	G	71493969	3	3	155	1	0	0	0	0	1	0	0	0	9281	130	5	5	4805	5	MAP1B	5	71493969	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	30334674	71493969	109421291	37	28722											
HOMER1	9456	broad.mit.edu	37	chr5	78752757	78752757	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaataagacacagtaactgcAtgcttgctggtgggtaccca	13	9	10	9	0	0	1	0	0	0	1	0	1	0	1	1	2	5	5	1	2	4	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:78752757A>G	uc003kfy.2	-	2	1193	c.90T>C	c.(88-90)CAT>CAC	p.H30H	HOMER1_uc010jab.2_Silent_p.H30H|HOMER1_uc010jac.2_Silent_p.H30H|HOMER1_uc010jad.2_Intron	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	30	WH1.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		CAGTAACTGCATGCTTGCTGG	0.418													11	128					0	0	0	0	G	78752757	G	G	78752757	2	3	155	1	0	0	0	0	0	0	0	1	7317	214	8	5		5	HOMER1	5	78752757	Silent	SNP	A	TCGA-CR-7389-01A-11D-2012-08	7258788	78752757	102162503	38	28723											
FBN2	2201	broad.mit.edu	37	chr5	127800510	127800510	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagggatggccccacgcccGtccaatggtggcacagcaca	10	4	12	15	2	0	0	0	0	0	0	1	1	1	1	4	4	1	2	4	4	1	0	rs146941428		TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:127800510G>A	uc003kuu.2	-	6	1172	c.733C>T	c.(733-735)CGG>TGG	p.R245W	FBN2_uc003kuv.2_Missense_Mutation_p.R212W|FBN2_uc003kuw.3_Missense_Mutation_p.R245W|FBN2_uc003kux.1_Missense_Mutation_p.R245W	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	245	TB 1.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCCCACGCCCGTCCAATGGTG	0.607													6	75					0	0	0	0	A	127800510	A	A	127800510	3	1	155	1	0	0	0	0	1	0	0	0	5735	1144	40	1	8245	1	FBN2	5	127800510	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	49047753	127800510	53114750	39	28724											
PCDHA6	56142	broad.mit.edu	37	chr5	140208448	140208448	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tattcgaaaatgcagacaacGgaacaacagttatcagactg	17	8	8	8	2	1	2	1	0	0	2	2	4	1	3	0	1	4	2	0	1	7	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:140208448G>A	uc003lho.2	+	1	799	c.772G>A	c.(772-774)GGA>AGA	p.G258R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.G258R|PCDHA6_uc011dab.1_Missense_Mutation_p.G258R	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	258	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGACAACGGAACAACAGT	0.423													11	54					0	0	0	0	A	140208448	A	A	140208448	3	1	155	1	0	0	0	0	1	0	0	0	11582	1117	39	1	774	1	PCDHA6	5	140208448	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	12407938	140208448	40706812	40	28725											
DIAPH1	1729	broad.mit.edu	37	chr5	140957813	140957813	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatctccatgcgaatgtcaTccagccgtcccttcaggtca	8	10	7	16	2	4	0	3	0	1	0	7	1	6	0	5	1	2	0	5	1	1	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:140957813T>A	uc003llb.3	-	11	1283	c.1142A>T	c.(1141-1143)GAT>GTT	p.D381V	DIAPH1_uc003llc.3_Missense_Mutation_p.D372V	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	381	GBD/FH3.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAATGTCATCCAGCCGTCC	0.433													17	67					0	0	0	0	A	140957813	A	A	140957813	3	1	155	1	0	0	0	0	1	0	0	0	4540	1435	50	5	2748	5	DIAPH1	5	140957813	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	749365	140957813	39957447	41	28726											
AFAP1L1	134265	broad.mit.edu	37	chr5	148679114	148679114	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcaccgggctgctcagccTcctggaccacgagtacctca	7	7	10	17	2	3	0	3	0	0	0	4	2	4	1	5	2	3	4	5	2	1	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:148679114T>A	uc003lqh.2	+	2	190	c.59T>A	c.(58-60)CTC>CAC	p.L20H	AFAP1L1_uc003lqg.3_Missense_Mutation_p.L20H|AFAP1L1_uc010jgy.2_Missense_Mutation_p.L20H	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	20							protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCTCAGCCTCCTGGACCAC	0.642													8	35					0	0	0	0	A	148679114	A	A	148679114	3	1	155	1	0	0	0	0	1	0	0	0	354	1551	54	5	65	5	AFAP1L1	5	148679114	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	7721301	148679114	32236146	42	28727											
ZNF300	91975	broad.mit.edu	37	chr5	150275862	150275862	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatgagttctctgatgtacAacaagatgaaacttctcact	13	13	7	8	0	2	4	1	3	2	1	4	4	2	4	0	0	3	3	0	0	5	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr5:150275862A>G	uc003lsy.1	-	6	1206	c.939T>C	c.(937-939)GTT>GTC	p.V313V	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	313	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCTGATGTACAACAAGATGAA	0.388													12	102					0	0	0	0	G	150275862	G	G	150275862	2	3	155	1	0	0	0	0	0	0	0	1	17898	117	5	5		5	ZNF300	5	150275862	Silent	SNP	A	TCGA-CR-7389-01A-11D-2012-08	1596748	150275862	30639398	43	28728											
SCAND3	114821	broad.mit.edu	37	chr6	28554347	28554347	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgaagcgctgacgagagaGttccctggtataagacaaat	13	8	11	9	2	0	4	0	2	0	2	1	6	1	4	2	1	1	3	2	1	4	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr6:28554347G>A	uc003nlo.2	-	1	766	c.148C>T	c.(148-150)CTC>TTC	p.L50F	uc003nlp.1_5'Flank	NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	50					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGACGAGAGAGTTCCCTGGTA	0.507													35	58					0	0	0	0	A	28554347	A	A	28554347	3	1	155	1	0	0	0	0	1	0	0	0	13941	1029	36	4	3845	4	SCAND3	6	28554347	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08		28554347	142560720	44	28729											
TAF8	129685	broad.mit.edu	37	chr6	42036251	42036251	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacctgacagctcttcttcCgtctgaactggagatgcaac	9	11	8	13	1	3	3	0	2	3	1	4	4	4	3	2	1	5	2	2	1	3	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr6:42036251C>A	uc003ors.2	+	7	715	c.686C>A	c.(685-687)CCG>CAG	p.P229Q	TAF8_uc003ort.2_Missense_Mutation_p.P229Q|TAF8_uc003oru.1_Missense_Mutation_p.P229Q|TAF8_uc003orv.1_Missense_Mutation_p.P229Q|TAF8_uc011dun.1_Missense_Mutation_p.P153Q	NM_138572	NP_612639	Q7Z7C8	TAF8_HUMAN	TBP-associated factor 8	229					cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			ovary(1)	1	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			GCTCTTCTTCCGTCTGAACTG	0.512													6	261					0.00198382	0.00681516	1	0	A	42036251	A	A	42036251	3	1	155	1	0	0	0	0	1	0	0	0	15600	652	23	3	712	3	TAF8	6	42036251	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	13481904	42036251	129078816	45	28730											
TCTE1	202500	broad.mit.edu	37	chr6	44247948	44247948	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagttctcagggccattggcAgttatggttgacatgaagtg	9	12	14	6	0	1	2	1	2	1	0	2	3	1	2	1	3	0	4	1	3	2	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr6:44247948A>T	uc003oxi.2	-	5	1632	c.1476T>A	c.(1474-1476)ACT>ACA	p.T492T	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	492										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGCCATTGGCAGTTATGGTTG	0.577													22	120					0	0	0	0	T	44247948	T	T	44247948	2	4	155	1	0	0	0	0	0	0	0	1	15783	175	7	5		5	TCTE1	6	44247948	Silent	SNP	A	TCGA-CR-7389-01A-11D-2012-08	2211697	44247948	126867119	46	28731											
IBTK	25998	broad.mit.edu	37	chr6	82950154	82950154	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaaggacatccaaagcaTgcttcagggatcgacacttt	14	8	9	10	1	1	1	1	0	0	1	3	4	2	3	1	2	2	2	1	2	2	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr6:82950154T>C	uc003pjl.1	-	2	577	c.50A>G	c.(49-51)CAT>CGT	p.H17R	IBTK_uc011dyv.1_Missense_Mutation_p.H17R|IBTK_uc011dyw.1_Missense_Mutation_p.H17R|IBTK_uc010kbi.1_5'UTR|IBTK_uc003pjm.2_Missense_Mutation_p.H17R	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	17					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		ATCCAAAGCATGCTTCAGGGA	0.408													13	130					0	0	0	0	C	82950154	C	C	82950154	3	2	155	1	0	0	0	0	1	0	0	0	7515	1464	51	5	4123	5	IBTK	6	82950154	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	38702206	82950154	88164913	47	28732											
HIVEP2	3097	broad.mit.edu	37	chr6	143093537	143093537	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acatcttgtctgaatcaatgGctgaaggtgactcctctgac	10	12	9	10	0	4	4	1	4	3	0	5	4	5	4	1	2	0	1	1	2	3	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr6:143093537G>A	uc003qjd.2	-	5	3082	c.2339C>T	c.(2338-2340)GCC>GTC	p.A780V		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	780					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TGAATCAATGGCTGAAGGTGA	0.512													13	64					0	0	0	0	A	143093537	A	A	143093537	3	1	155	1	0	0	0	0	1	0	0	0	7226	1203	42	4	5025	4	HIVEP2	6	143093537	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	60143383	143093537	28021530	48	28733											
PLEKHG1	57480	broad.mit.edu	37	chr6	151121855	151121855	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aacatggactcttcctgcagGtccgtggctgtgctaacaga	9	10	11	11	1	1	1	0	0	1	1	3	2	3	2	2	3	4	3	2	3	2	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr6:151121855G>A	uc003qny.1	+	7	942	c.630G>A	c.(628-630)AGG>AGA	p.R210R	PLEKHG1_uc011eel.1_Silent_p.R250R|PLEKHG1_uc011eem.1_Silent_p.R269R|PLEKHG1_uc003qnz.2_Silent_p.R210R	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	210	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		CTTCCTGCAGGTCCGTGGCTG	0.428													6	55					0	0	0	0	A	151121855	A	A	151121855	2	1	155	1	0	0	0	0	0	0	0	1	12123	1275	44	4		4	PLEKHG1	6	151121855	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	8028318	151121855	19993212	49	28734											
CYTH3	9265	broad.mit.edu	37	chr7	6213353	6213353	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggcttgaagaactttaataTtaaattcatccctgggaaaa	16	12	7	6	0	1	2	1	1	0	1	2	3	2	3	1	2	1	1	1	2	8	6			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr7:6213353T>C	uc003spt.2	-	6	484	c.380A>G	c.(379-381)AAT>AGT	p.N127S	CYTH3_uc011jws.1_5'Flank	NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3	127	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						AACTTTAATATTAAATTCATC	0.323													21	30					0	0	0	0	C	6213353	C	C	6213353	3	2	155	1	0	0	0	0	1	0	0	0	4222	1493	52	5	851	5	CYTH3	7	6213353	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08		6213353	152925310	50	28735											
ZNF479	90827	broad.mit.edu	37	chr7	57188428	57188428	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctccagtatgaattatttTatgtgtagtatggtttgagg	9	18	10	4	0	1	2	0	2	1	0	2	2	1	2	1	2	0	4	1	2	6	7			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr7:57188428T>A	uc010kzo.2	-	5	965	c.694A>T	c.(694-696)AAA>TAA	p.K232*		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	232	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TGAATTATTTTATGTGTAGTA	0.383													5	25					0	0	0	0	A	57188428	A	A	57188428	4	1	155	1	0	0	0	0	0	1	0	0	18000	1763	61	5	884	5	ZNF479	7	57188428	Nonsense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	50975075	57188428	101950235	51	28736											
LIMK1	3984	broad.mit.edu	37	chr7	73535347	73535347	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgagcttcttccccatcacCgtgcgctgttgcgatctgga	5	11	10	15	4	3	0	1	0	2	0	4	3	4	1	4	1	3	3	4	1	0	3	rs55722104		TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr7:73535347C>T	uc003uaa.1	+	15	1914	c.1749C>T	c.(1747-1749)ACC>ACT	p.T583T	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Silent_p.T549T	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	583	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				TCCCCATCACCGTGCGCTGTT	0.662													41	189					0	0	0	0	T	73535347	T	T	73535347	2	4	155	1	0	0	0	0	0	0	0	1	8842	639	23	1		1	LIMK1	7	73535347	Silent	SNP	C	TCGA-CR-7389-01A-11D-2012-08	16346919	73535347	85603316	52	28737											
GNAT3	346562	broad.mit.edu	37	chr7	80091818	80091818	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttttcctttagacttacCacttcttcgtcttccacgag	6	18	5	12	2	2	1	0	0	2	1	5	2	4	1	3	0	1	1	3	0	2	8			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr7:80091818C>T	uc011kgu.1	-	6	720	c.720G>A	c.(718-720)GTG>GTA	p.V240V	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	240					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						TTAGACTTACCACTTCTTCGT	0.398													14	93					0	0	0	0	T	80091818	T	T	80091818	2	4	155	1	0	0	0	0	0	0	0	1	6550	608	21	4		4	GNAT3	7	80091818	Silent	SNP	C	TCGA-CR-7389-01A-11D-2012-08	6556471	80091818	79046845	53	28738											
CUX1	1523	broad.mit.edu	37	chr7	101844978	101844978	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggacccccagggagcagccGattgtgcacaaggggtcctg	8	6	15	12	1	0	0	0	0	0	0	1	3	1	2	4	4	3	2	4	4	1	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr7:101844978G>A	uc003uyx.3	+	18	2439	c.2401G>A	c.(2401-2403)GAT>AAT	p.D801N	CUX1_uc003uys.3_Missense_Mutation_p.D812N|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	801					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GGGAGCAGCCGATTGTGCACA	0.672													19	23					0	0	0	0	A	101844978	A	A	101844978	3	1	155	1	0	0	0	0	1	0	0	0	4081	1058	37	1	2538	1	CUX1	7	101844978	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	21753160	101844978	57293685	54	28739											
GPR124	25960	broad.mit.edu	37	chr8	37699033	37699033	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtacggggtggcagcctcCgccctgggcctcttcgtctt	2	12	13	14	3	2	0	0	0	2	0	4	0	3	0	4	4	2	2	4	4	1	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr8:37699033C>T	uc003xkj.2	+	19	3540	c.3177C>T	c.(3175-3177)TCC>TCT	p.S1059S	GPR124_uc010lvy.2_Silent_p.S842S	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	1059	Helical; Name=7; (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TGGCAGCCTCCGCCCTGGGCC	0.647													5	28					0	0	0	0	T	37699033	T	T	37699033	2	4	155	1	0	0	0	0	0	0	0	1	6676	639	23	1		1	GPR124	8	37699033	Silent	SNP	C	TCGA-CR-7389-01A-11D-2012-08		37699033	108664989	55	28740											
RP1	6101	broad.mit.edu	37	chr8	55533931	55533931	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcagccgggccattagcgcGcactcaccgccccaccccgt	7	4	10	20	5	1	0	1	0	0	0	1	0	1	0	7	1	3	2	7	1	1	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr8:55533931G>A	uc003xsd.1	+	2	553	c.405G>A	c.(403-405)GCG>GCA	p.A135A	RP1_uc011ldy.1_Silent_p.A135A	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	135					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding	p.A135V(1)		skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCATTAGCGCGCACTCACCGC	0.692													5	92					0	0	0	0	A	55533931	A	A	55533931	2	1	155	1	0	0	0	0	0	0	0	1	13597	1074	38	1		1	RP1	8	55533931	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	17834898	55533931	90830091	56	28741											
RUNX1T1	862	broad.mit.edu	37	chr8	92972688	92972688	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaatgagccacagtatcGggctgtgttacagccactgc	11	8	11	11	1	0	1	0	1	0	0	1	1	0	1	2	1	4	4	2	1	4	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr8:92972688G>A	uc003yfd.2	-	11	1681	c.1597C>T	c.(1597-1599)CGA>TGA	p.R533*	RUNX1T1_uc003yfc.1_Nonsense_Mutation_p.R506*|RUNX1T1_uc003yfe.1_Nonsense_Mutation_p.R496*|RUNX1T1_uc010mao.2_Nonsense_Mutation_p.R506*|RUNX1T1_uc011lgi.1_Nonsense_Mutation_p.R544*|uc010mam.2_5'Flank|RUNX1T1_uc010man.1_Nonsense_Mutation_p.R158*|RUNX1T1_uc003yfb.1_Nonsense_Mutation_p.R496*	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	533	MYND-type.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CCACAGTATCGGGCTGTGTTA	0.517													30	48					0	0	0	0	A	92972688	A	A	92972688	4	1	155	1	0	0	0	0	0	1	0	0	13812	1124	39	1	221	1	RUNX1T1	8	92972688	Nonsense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	37438757	92972688	53391334	57	28742											
TM7SF4	81501	broad.mit.edu	37	chr8	105361565	105361565	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaagggagagacatcaacAgaggccctgtgtgctcccgc	11	6	13	11	1	1	3	1	1	0	2	2	5	2	4	2	2	2	1	2	2	2	0			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr8:105361565A>T	uc003ylx.1	+	2	834	c.785A>T	c.(784-786)CAG>CTG	p.Q262L		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	262					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AGACATCAACAGAGGCCCTGT	0.468													13	93					0	0	0	0	T	105361565	T	T	105361565	3	4	155	1	0	0	0	0	1	0	0	0	16042	188	7	5	787	5	TM7SF4	8	105361565	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	12388877	105361565	41002457	58	28743											
ANGPT1	284	broad.mit.edu	37	chr8	108264120	108264120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatcatcatagttgtggaaCgtaaggagtaactgggccct	12	10	12	7	1	2	0	2	0	0	0	2	3	2	2	1	3	2	3	1	3	5	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr8:108264120C>T	uc003ymn.2	-	9	1928	c.1460G>A	c.(1459-1461)CGT>CAT	p.R487H	ANGPT1_uc011lhv.1_Missense_Mutation_p.R287H|ANGPT1_uc003ymo.2_Missense_Mutation_p.R486H	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	487	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			AGTTGTGGAACGTAAGGAGTA	0.428													7	147					0	0	0	0	T	108264120	T	T	108264120	3	4	155	1	0	0	0	0	1	0	0	0	610	536	19	1	40	1	ANGPT1	8	108264120	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	2902555	108264120	38099902	59	28744											
PKHD1L1	93035	broad.mit.edu	37	chr8	110455268	110455268	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catttttctccaaggagtcaTtaatgttttaccagctgaaa	12	15	6	8	0	2	1	1	1	1	0	3	2	2	2	2	1	2	2	2	1	4	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr8:110455268T>C	uc003yne.2	+	36	4591	c.4487T>C	c.(4486-4488)ATT>ACT	p.I1496T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1496	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CAAGGAGTCATTAATGTTTTA	0.418										HNSCC(38;0.096)			36	210					0	0	0	0	C	110455268	C	C	110455268	3	2	155	1	0	0	0	0	1	0	0	0	12027	1493	52	5	4629	5	PKHD1L1	8	110455268	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	2191148	110455268	35908754	60	28745											
ADCY8	114	broad.mit.edu	37	chr8	131880107	131880107	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaccttgaagaaggaagcAaactttgtattgccgtgata	13	13	9	6	1	0	3	0	2	0	1	0	4	0	4	2	1	4	2	2	1	7	7			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr8:131880107A>G	uc003ytd.3	-	9	2451	c.2195T>C	c.(2194-2196)TTG>TCG	p.L732S	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	732	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGAAGGAAGCAAACTTTGTAT	0.343										HNSCC(32;0.087)			5	44					0	0	0	0	G	131880107	G	G	131880107	3	3	155	1	0	0	0	0	1	0	0	0	300	131	5	5	1600	5	ADCY8	8	131880107	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	21424839	131880107	14483915	61	28746											
FAM75A6	389730	broad.mit.edu	37	chr9	43627396	43627396	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacctgtcagttacccaggCgttagccaccagggactcgc	9	7	11	14	2	1	1	1	0	0	1	2	2	1	2	4	2	2	2	4	2	2	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr9:43627396C>T	uc011lrb.1	-	4	1320	c.1291G>A	c.(1291-1293)GCC>ACC	p.A431T		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	431						integral to membrane					0						GTTACCCAGGCGTTAGCCACC	0.488													48	78					0	0	0	0	T	43627396	T	T	43627396	3	4	155	1	0	0	0	0	1	0	0	0	5654	768	27	1	2744	1	FAM75A6	9	43627396	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08		43627396	97586035	62	28747											
ROR2	4920	broad.mit.edu	37	chr9	94486931	94486931	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcacattgcgggtggccagGtccttgtgaaccacgtggtg	7	9	15	10	2	0	1	0	1	0	0	1	1	1	1	3	4	3	1	3	4	1	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr9:94486931G>A	uc004arj.1	-	9	2044	c.1845C>T	c.(1843-1845)GAC>GAT	p.D615D	ROR2_uc004ari.1_Silent_p.D475D	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	615	Cytoplasmic (Potential).|Protein kinase.	Proton acceptor (By similarity).			negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GGGTGGCCAGGTCCTTGTGAA	0.597													16	105					0	0	0	0	A	94486931	A	A	94486931	2	1	155	1	0	0	0	0	0	0	0	1	13592	1252	44	4		4	ROR2	9	94486931	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	50859535	94486931	46726500	63	28748											
OMD	4958	broad.mit.edu	37	chr9	95179448	95179448	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaaacacaccataatcaatCttttgagatttaattttgtt	14	16	4	7	0	2	1	1	1	1	1	2	2	2	1	1	0	1	2	1	0	4	8			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr9:95179448C>G	uc004asd.3	-	2	762	c.393G>C	c.(391-393)AAG>AAC	p.K131N	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron	NM_005014	NP_005005	Q99983	OMD_HUMAN	osteomodulin precursor	131					cell adhesion	proteinaceous extracellular matrix				ovary(2)	2						CATAATCAATCTTTTGAGATT	0.328			T	USP6	aneurysmal bone cysts								6	109					0	0	0	0	G	95179448	G	G	95179448	3	3	155	1	0	0	0	0	1	0	0	0	10919	912	32	2	880	2	OMD	9	95179448	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	692517	95179448	46033983	64	28749											
SMC2	10592	broad.mit.edu	37	chr9	106891994	106891994	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctttggccaacccaatagTgcctatgatttcaaaactaa	13	12	5	11	0	2	1	1	1	1	0	2	1	2	1	3	1	3	0	3	1	7	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr9:106891994T>C	uc004bbv.2	+	21	3147	c.2859T>C	c.(2857-2859)AGT>AGC	p.S953S	SMC2_uc004bbw.2_Silent_p.S953S|SMC2_uc011lvl.1_Silent_p.S953S|SMC2_uc004bbx.2_Silent_p.S953S|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	953					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						AACCCAATAGTGCCTATGATT	0.378													5	124					0	0	0	0	C	106891994	C	C	106891994	2	2	155	1	0	0	0	0	0	0	0	1	14847	1693	59	5		5	SMC2	9	106891994	Silent	SNP	T	TCGA-CR-7389-01A-11D-2012-08	11712546	106891994	34321437	65	28750											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112899866	112899866	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcactgtggtcaaggatgAtgaccatgggattttggatc	9	12	12	8	0	2	2	2	2	0	0	3	5	2	5	2	4	0	0	2	4	1	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr9:112899866A>T	uc004bei.2	+	9	2930	c.2738A>T	c.(2737-2739)GAT>GTT	p.D913V	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.D681V|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.D681V|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.D491V|AKAP2_uc011lwi.1_Missense_Mutation_p.D539V|AKAP2_uc004bem.2_Missense_Mutation_p.D539V|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.D499V|AKAP2_uc011lwj.1_Missense_Mutation_p.D450V|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.D450V	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	450							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						GTCAAGGATGATGACCATGGG	0.522													84	87					0	0	0	0	T	112899866	T	T	112899866	3	4	155	1	0	0	0	0	1	0	0	0	11464	333	12	5	2072	5	PALM2-AKAP2	9	112899866	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	6007872	112899866	28313565	66	28751											
ITGA8	8516	broad.mit.edu	37	chr10	15647748	15647748	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agccgacagcttcaagtcagGaacacacagattgtcttctc	12	9	8	12	1	4	1	2	0	2	1	5	3	4	2	1	1	3	1	1	1	2	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr10:15647748G>T	uc001ioc.1	-	19	1945	c.1945C>A	c.(1945-1947)CCT>ACT	p.P649T	ITGA8_uc010qcb.1_Missense_Mutation_p.P634T	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	649	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TTCAAGTCAGGAACACACAGA	0.388													6	31					8.12818e-05	0.000283085	1	0	T	15647748	T	T	15647748	3	4	155	1	0	0	0	0	1	0	0	0	7921	1174	41	2	1294	2	ITGA8	10	15647748	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08		15647748	119886999	67	28752											
PLXDC2	84898	broad.mit.edu	37	chr10	20568717	20568717	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttgaaccagttggagagaAagaaggctttattgtatcag	14	11	12	4	0	1	3	1	1	0	2	1	5	1	4	1	2	1	4	1	2	5	6			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr10:20568717A>G	uc001iqg.1	+	14	2196	c.1559A>G	c.(1558-1560)AAA>AGA	p.K520R	PLXDC2_uc001iqh.1_Missense_Mutation_p.K471R|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	520	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						GTTGGAGAGAAAGAAGGCTTT	0.423													3	44					0	0	0	0	G	20568717	G	G	20568717	3	3	155	1	0	0	0	0	1	0	0	0	12173	14	1	5	1613	5	PLXDC2	10	20568717	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	4920969	20568717	114966030	68	28753											
CTNNA3	29119	broad.mit.edu	37	chr10	69407256	69407256	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcgatattcaatgtgattgGtgtttcagctgacatgctgc	9	15	10	7	1	2	2	2	2	0	0	3	3	2	2	0	1	3	3	0	1	2	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr10:69407256G>A	uc009xpn.1	-	2	139	c.16C>T	c.(16-18)CCA>TCA	p.P6S	CTNNA3_uc001jmw.2_Missense_Mutation_p.P6S|CTNNA3_uc001jmx.3_Missense_Mutation_p.P6S|CTNNA3_uc009xpo.1_5'UTR|CTNNA3_uc001jna.2_Missense_Mutation_p.P18S	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	6					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						AATGTGATTGGTGTTTCAGCT	0.393													13	105					0	0	0	0	A	69407256	A	A	69407256	3	1	155	1	0	0	0	0	1	0	0	0	4031	1261	44	4	2739	4	CTNNA3	10	69407256	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	48838539	69407256	66127491	69	28754											
USP54	159195	broad.mit.edu	37	chr10	75289616	75289616	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgggggcttggtccaccaaAtttaatgtcgtaagaaggtg	10	11	13	7	1	0	1	0	0	0	1	2	1	1	1	2	4	0	2	2	4	4	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr10:75289616A>G	uc001juo.2	-	13	1899	c.1882T>C	c.(1882-1884)TTT>CTT	p.F628L	USP54_uc001juk.2_5'UTR|USP54_uc001jul.2_5'UTR|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA|USP54_uc001jup.2_Missense_Mutation_p.F628L|USP54_uc010qkl.1_Missense_Mutation_p.F628L	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	628					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					GGTCCACCAAATTTAATGTCG	0.483											OREG0020266	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	130					0	0	0	0	G	75289616	G	G	75289616	3	3	155	1	0	0	0	0	1	0	0	0	17153	101	4	5	3212	5	USP54	10	75289616	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	5882360	75289616	60245131	70	28755											
NDST2	8509	broad.mit.edu	37	chr10	75567972	75567972	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggccaggaccagctgcccCaccgctgctgcagtctccca	7	5	11	18	1	1	0	0	0	1	0	2	1	1	1	6	2	4	4	6	2	0	0			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr10:75567972C>T	uc001jvk.2	-	3	979	c.175G>A	c.(175-177)GGG>AGG	p.G59R	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Intron|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_5'Flank	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	59	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					CCAGCTGCCCCACCGCTGCTG	0.632													3	16					0	0	0	0	T	75567972	T	T	75567972	3	4	155	1	0	0	0	0	1	0	0	0	10310	594	21	4	2528	4	NDST2	10	75567972	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	278356	75567972	59966775	71	28756											
IFIT3	3437	broad.mit.edu	37	chr10	91098946	91098946	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcctctggactggcaatTgcgatgtaccatctggataa	9	13	9	10	1	3	0	0	0	3	0	4	3	3	2	2	3	2	2	2	3	3	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr10:91098946T>C	uc001kgf.2	+	2	763	c.534T>C	c.(532-534)ATT>ATC	p.I178I	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron|IFIT3_uc001kgg.2_Silent_p.I178I	NM_001549	NP_001540	O14879	IFIT3_HUMAN	interferon-induced protein with	178	TPR 4.				type I interferon-mediated signaling pathway		protein binding			central_nervous_system(1)	1						GACTGGCAATTGCGATGTACC	0.458													15	91					0	0	0	0	C	91098946	C	C	91098946	2	2	155	1	0	0	0	0	0	0	0	1	7563	1800	63	5		5	IFIT3	10	91098946	Silent	SNP	T	TCGA-CR-7389-01A-11D-2012-08	15530974	91098946	44435801	72	28757											
SORBS1	10580	broad.mit.edu	37	chr10	97174256	97174256	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccagcaagcttacggtacTcgaaacagctcccgtgaggt	10	8	11	12	3	0	1	0	1	0	0	3	2	2	1	2	2	6	4	2	2	4	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr10:97174256T>A	uc001kkp.2	-	7	850	c.805A>T	c.(805-807)AGT>TGT	p.S269C	SORBS1_uc001kkl.2_5'UTR|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Missense_Mutation_p.S269C|SORBS1_uc001kkq.2_Missense_Mutation_p.S200C|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Missense_Mutation_p.S237C|SORBS1_uc001kkw.2_Missense_Mutation_p.S269C|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Missense_Mutation_p.S467C|SORBS1_uc001kkx.1_Missense_Mutation_p.S237C	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	269					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CTTACGGTACTCGAAACAGCT	0.602													8	47					0	0	0	0	A	97174256	A	A	97174256	3	1	155	1	0	0	0	0	1	0	0	0	14991	1551	54	5	3370	5	SORBS1	10	97174256	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	6075310	97174256	38360491	73	28758											
C10orf120	399814	broad.mit.edu	37	chr10	124459210	124459210	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaagagttggtattaaataTtctaactggcttttcattct	11	17	8	5	0	3	1	1	0	2	1	3	2	3	2	0	3	1	3	0	3	6	9			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr10:124459210T>C	uc001lgn.2	-	1	129	c.97A>G	c.(97-99)ATA>GTA	p.I33V		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	33										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				GTATTAAATATTCTAACTGGC	0.433													15	58					0	0	0	0	C	124459210	C	C	124459210	3	2	155	1	0	0	0	0	1	0	0	0	1596	1493	52	5	922	5	C10orf120	10	124459210	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	27284954	124459210	11075537	74	28759											
OR8H1	219469	broad.mit.edu	37	chr11	56057819	56057819	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcccaagagatgagaggcAcaagtagacaaagctttctg	15	7	10	9	0	1	3	0	1	1	3	2	5	2	3	1	1	1	3	1	1	4	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr11:56057819A>G	uc010rje.1	-	1	720	c.720T>C	c.(718-720)TGT>TGC	p.C240C		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GATGAGAGGCACAAGTAGACA	0.383													12	60					0	0	0	0	G	56057819	G	G	56057819	2	3	155	1	0	0	0	0	0	0	0	1	11291	157	6	5		5	OR8H1	11	56057819	Silent	SNP	A	TCGA-CR-7389-01A-11D-2012-08		56057819	78948697	75	28760											
OR5M8	219484	broad.mit.edu	37	chr11	56258800	56258800	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaattcccggcgactggtcAgtcccaggagaatgaactca	11	8	11	11	2	2	2	2	1	0	1	4	4	4	2	2	3	1	1	2	3	3	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr11:56258800A>T	uc001nix.1	-	1	47	c.47T>A	c.(46-48)CTG>CAG	p.L16Q		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					GCGACTGGTCAGTCCCAGGAG	0.448													17	74					0	0	0	0	T	56258800	T	T	56258800	3	4	155	1	0	0	0	0	1	0	0	0	11230	188	7	5	892	5	OR5M8	11	56258800	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	200981	56258800	78747716	76	28761											
OSBP	5007	broad.mit.edu	37	chr11	59361545	59361545	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagctcaaaggtctccccaaGcagtgggttgaatggcttac	10	9	11	11	0	2	1	1	1	1	0	3	1	2	1	2	3	3	4	2	3	4	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr11:59361545G>T	uc001noc.1	-	8	1975	c.1495C>A	c.(1495-1497)CTT>ATT	p.L499I	OSBP_uc009ymr.1_RNA	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	499					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GTCTCCCCAAGCAGTGGGTTG	0.488													4	28					0.000602214	0.002083	1	0	T	59361545	T	T	59361545	3	4	155	1	0	0	0	0	1	0	0	0	11327	971	34	4	956	4	OSBP	11	59361545	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	3102745	59361545	75644971	77	28762											
ZBTB3	79842	broad.mit.edu	37	chr11	62521078	62521078	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtcacaaaggaaacccTgggaccgctgctcccggagg	10	5	13	13	2	1	0	1	0	0	0	2	3	2	3	3	4	3	3	3	4	2	0			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr11:62521078T>A	uc001nuz.2	-	2	331	c.209A>T	c.(208-210)CAG>CTG	p.Q70L		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	70					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						AAGGAAACCCTGGGACCGCTG	0.592													9	30					0	0	0	0	A	62521078	A	A	62521078	3	1	155	1	0	0	0	0	1	0	0	0	17601	1580	55	5	1519	5	ZBTB3	11	62521078	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	3159533	62521078	72485438	78	28763											
KDELC2	143888	broad.mit.edu	37	chr11	108348424	108348424	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttttgcaatcttcttggcTtcttcatcattttcctgaaa	7	20	4	10	0	6	1	2	1	4	0	7	1	7	1	1	1	1	2	1	1	2	8			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr11:108348424T>C	uc001pkj.2	-	7	1374	c.1308A>G	c.(1306-1308)GAA>GAG	p.E436E	KDELC2_uc001pki.2_Silent_p.E380E	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	436						endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		TCTTCTTGGCTTCTTCATCAT	0.413													17	71					0	0	0	0	C	108348424	C	C	108348424	2	2	155	1	0	0	0	0	0	0	0	1	8157	1606	56	5		5	KDELC2	11	108348424	Silent	SNP	T	TCGA-CR-7389-01A-11D-2012-08	45827346	108348424	26658092	79	28764											
ALG9	79796	broad.mit.edu	37	chr11	111739396	111739396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caacaggtaagcataggagcGaatggcatatgctggggaat	14	7	14	6	1	0	0	0	0	0	0	0	3	0	2	0	5	4	4	0	5	6	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr11:111739396G>A	uc001pmb.2	-	4	433	c.334C>T	c.(334-336)CGC>TGC	p.R112C	ALG9_uc001ply.2_5'UTR|ALG9_uc001plz.2_5'UTR|ALG9_uc010rwm.1_Missense_Mutation_p.R112C|ALG9_uc010rwn.1_Missense_Mutation_p.R66C|ALG9_uc010rwo.1_5'UTR|ALG9_uc009yyh.1_Silent_p.F30F	NM_001077690	NP_001071158	Q9H6U8	ALG9_HUMAN	asparagine-linked glycosylation 9 protein	112	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			large_intestine(1)|ovary(1)	2		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		GCATAGGAGCGAATGGCATAT	0.433													8	43					0	0	0	0	A	111739396	A	A	111739396	3	1	155	1	0	0	0	0	1	0	0	0	524	1058	37	1	1574	1	ALG9	11	111739396	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	3390972	111739396	23267120	80	28765											
C11orf1	64776	broad.mit.edu	37	chr11	111753218	111753218	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtatggatggcgatgcAccactaatgagaatacctat	13	10	9	9	1	0	1	0	1	0	1	1	4	1	2	3	2	2	2	3	2	5	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr11:111753218A>G	uc001pmd.2	+	2	509	c.172A>G	c.(172-174)ACC>GCC	p.T58A	C11orf1_uc001pme.2_Missense_Mutation_p.T98A	NM_022761	NP_073598	Q9H5F2	CK001_HUMAN	hypothetical protein LOC64776	58						nucleus					0		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		ATGGCGATGCACCACTAATGA	0.468													6	40					0	0	0	0	G	111753218	G	G	111753218	3	3	155	1	0	0	0	0	1	0	0	0	1635	159	6	5	178	5	C11orf1	11	111753218	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	13822	111753218	23253298	81	28766											
ZNF202	7753	broad.mit.edu	37	chr11	123597309	123597309	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttgtaaggcgcgttcatcTtgtgaaccttttggtgcctg	6	16	11	8	2	2	1	1	1	1	0	2	1	2	1	2	2	2	2	2	2	2	6			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr11:123597309T>A	uc001pzd.1	-	9	1743	c.1343A>T	c.(1342-1344)AAG>ATG	p.K448M	ZNF202_uc001pzc.1_Missense_Mutation_p.K224M|ZNF202_uc001pze.1_Missense_Mutation_p.K448M|ZNF202_uc001pzf.1_Missense_Mutation_p.K448M	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	448					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CGCGTTCATCTTGTGAACCTT	0.468													18	78					0	0	0	0	A	123597309	A	A	123597309	3	1	155	1	0	0	0	0	1	0	0	0	17830	1609	56	5	607	5	ZNF202	11	123597309	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	11844091	123597309	11409207	82	28767											
ZBTB44	29068	broad.mit.edu	37	chr11	130131282	130131282	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactgcactctgaggacaCgggagaaatgctcccatctc	11	7	9	14	1	2	2	0	1	2	1	4	4	3	3	1	2	2	2	1	2	1	0			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr11:130131282C>A	uc001qga.2	-	2	881	c.487G>T	c.(487-489)GTG>TTG	p.V163L	ZBTB44_uc001qgb.3_Missense_Mutation_p.V163L|ZBTB44_uc001qfx.2_RNA|ZBTB44_uc001qgc.1_Missense_Mutation_p.V163L|ZBTB44_uc001qfz.2_Missense_Mutation_p.V163L	NM_014155	NP_054874	Q8NCP5	ZBT44_HUMAN	zinc finger and BTB domain containing 44	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0192)|Lung(977;0.235)		TCTGAGGACACGGGAGAAATG	0.453													8	42					5.18039e-06	1.84232e-05	1	0	A	130131282	A	A	130131282	3	1	155	1	0	0	0	0	1	0	0	0	17612	536	19	3	894	3	ZBTB44	11	130131282	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	6533973	130131282	4875234	83	28768											
KDM5A	5927	broad.mit.edu	37	chr12	464365	464365	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccgttgtctcatttgcaTgttaaatgcgtctgacctgt	6	18	8	9	2	2	1	1	1	2	0	4	1	3	1	2	0	2	3	2	0	2	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:464365T>C	uc001qif.1	-	7	1192	c.829A>G	c.(829-831)ATG>GTG	p.M277V	KDM5A_uc001qie.1_Missense_Mutation_p.M277V|KDM5A_uc010sdn.1_Missense_Mutation_p.M236V|KDM5A_uc010sdo.1_Intron	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	277					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						CTCATTTGCATGTTAAATGCG	0.328			T 	NUP98	AML								10	37					0	0	0	0	C	464365	C	C	464365	3	2	155	1	0	0	0	0	1	0	0	0	8172	1464	51	5	4331	5	KDM5A	12	464365	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08		464365	133387530	84	28769											
C12orf36	283422	broad.mit.edu	37	chr12	13526327	13526327	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagcagaatgtgtctacgagCgctctgactcttccagggaa	10	9	11	11	2	3	2	0	1	3	1	4	4	4	3	1	1	3	2	1	1	3	2	rs146660868		TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:13526327C>T	uc001rbs.1	-	3	446	c.228G>A	c.(226-228)GAG>GAA	p.E76E		NM_182558	NP_872364			hypothetical protein LOC283422												0				BRCA - Breast invasive adenocarcinoma(232;0.198)		TGTCTACGAGCGCTCTGACTC	0.473													12	51					0	0	0	0	T	13526327	T	T	13526327	2	4	155	1	0	0	0	0	0	0	0	1	1689	755	27	1		1	C12orf36	12	13526327	Silent	SNP	C	TCGA-CR-7389-01A-11D-2012-08	13061962	13526327	120325568	85	28770											
PTPRO	5800	broad.mit.edu	37	chr12	15733638	15733638	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acttatctttcagggatacaActcaccccaggagtatattg	12	12	7	10	0	3	0	2	0	1	0	3	2	3	2	2	2	2	1	2	2	5	6			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:15733638A>G	uc001rcv.1	+	22	3179	c.3005A>G	c.(3004-3006)AAC>AGC	p.N1002S	PTPRO_uc001rcw.1_Missense_Mutation_p.N974S|PTPRO_uc001rcx.1_Missense_Mutation_p.N191S|PTPRO_uc001rcy.1_Missense_Mutation_p.N191S|PTPRO_uc001rcz.1_Missense_Mutation_p.N163S|PTPRO_uc001rda.1_Missense_Mutation_p.N163S	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	1002	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				CAGGGATACAACTCACCCCAG	0.438													10	30					0	0	0	0	G	15733638	G	G	15733638	3	3	155	1	0	0	0	0	1	0	0	0	12874	43	2	5	3091	5	PTPRO	12	15733638	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	2207311	15733638	118118257	86	28771											
COL2A1	1280	broad.mit.edu	37	chr12	48367278	48367278	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgtcaatgatggggaggCgtgaggtcttctgtgaccgg	8	10	16	7	2	3	3	1	3	2	0	3	4	3	4	1	5	0	0	1	5	2	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:48367278C>T	uc001rqu.2	-	54	4557	c.4376G>A	c.(4375-4377)CGC>CAC	p.R1459H	COL2A1_uc001rqt.2_Missense_Mutation_p.R240H|COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.R1390H	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	1459	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GATGGGGAGGCGTGAGGTCTT	0.527													24	56					0	0	0	0	T	48367278	T	T	48367278	3	4	155	1	0	0	0	0	1	0	0	0	3702	768	27	1	91	1	COL2A1	12	48367278	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	32633640	48367278	85484617	87	28772											
MLL2	8085	broad.mit.edu	37	chr12	49440414	49440415	+	Frame_Shift_Ins	INS	-	G	G																															ttgcacttccagccgcccttINSggggacggtgagcagtgggg																										TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:49440414_49440415insG	uc001rta.3	-	15	4395_4396	c.4395_4396insC	c.(4393-4398)CCCAAGfs	p.P1465fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1465_1466	Cys-rich.|PHD-type 4.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding	p.K1193fs*25(1)		kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CAGCCGCCCTTGGGGACGGTGA	0.559			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								G	49440415	G	G	49440414	7	5	155	1	0	1	1	0	0	0	0	0	9674	1821	63	0	12377	0	MLL2	12	49440414	Frame_Shift_Ins	INS	-	TCGA-CR-7389-01A-11D-2012-08	1073136	49440414	84411481	88	28773											
PRPF40B	25766	broad.mit.edu	37	chr12	50036081	50036081	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaggcacgcaggatgcggCgcagggaagctgcctttcga	9	5	17	10	4	0	0	0	0	0	0	1	4	0	3	1	5	3	4	1	5	1	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:50036081C>T	uc001rur.1	+	19	1946	c.1882C>T	c.(1882-1884)CGC>TGC	p.R628C	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001rup.1_Missense_Mutation_p.R650C|PRPF40B_uc001ruq.1_Missense_Mutation_p.R615C|PRPF40B_uc001rus.1_Missense_Mutation_p.R571C|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	628					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CAGGATGCGGCGCAGGGAAGC	0.642													8	84					0	0	0	0	T	50036081	T	T	50036081	3	4	155	1	0	0	0	0	1	0	0	0	12634	768	27	1	1956	1	PRPF40B	12	50036081	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	595667	50036081	83815814	89	28774											
KRT1	3848	broad.mit.edu	37	chr12	53069124	53069124	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccggccgccagagctgccGccgccgccgcctccagagcc	4	2	12	23	6	0	2	0	0	0	2	1	2	1	2	11	1	3	1	11	1	0	0			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:53069124G>A	uc001sau.1	-	9	1847	c.1788C>T	c.(1786-1788)GGC>GGT	p.G596G	KRT1_uc001sav.1_Silent_p.G589G	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	596	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						cagagctgccgccgccgccgc	0.289													9	37					0	0	0	0	A	53069124	A	A	53069124	2	1	155	1	0	0	0	0	0	0	0	1	8486	1074	38	1		1	KRT1	12	53069124	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	3033043	53069124	80782771	90	28775											
ATP5G2	517	broad.mit.edu	37	chr12	54063126	54063126	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgccaagctgctgaggctCtgtgaaaaagaggcaggtag	12	7	14	8	0	1	3	0	2	1	1	1	3	1	3	1	3	3	5	1	3	4	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:54063126C>T	uc009znc.2	-	5	819	c.118_splice	c.e5-1	p.S40_splice	ATP5G2_uc001sec.2_Splice_Site_p.S97_splice|ATP5G2_uc001sed.2_Splice_Site_p.S56_splice	NM_001002031	NP_001002031	Q06055	AT5G2_HUMAN	ATP synthase, H+ transporting, mitochondrial F0						ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding			ovary(1)	1						TGCTGAGGCTCTGTGAAAAAG	0.473													3	22					0	0	0	0	T	54063126	T	T	54063126	5	4	155	1	0	0	0	0	0	0	1	0	1156	927	32	2	316	2	ATP5G2	12	54063126	Splice_Site	SNP	C	TCGA-CR-7389-01A-11D-2012-08	994002	54063126	79788769	91	28776											
C12orf63	374467	broad.mit.edu	37	chr12	97073479	97073479	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatccaaataccataacagaTcaatccgacacagcagaaag	20	5	5	11	1	1	2	1	0	0	2	3	3	3	2	3	0	3	1	3	0	6	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:97073479T>A	uc001tet.1	+	7	1018	c.940T>A	c.(940-942)TCA>ACA	p.S314T		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	314										skin(6)|ovary(1)	7						CCATAACAGATCAATCCGACA	0.443													34	87					0	0	0	0	A	97073479	A	A	97073479	3	1	155	1	0	0	0	0	1	0	0	0	1712	1435	50	5	962	5	C12orf63	12	97073479	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	43010353	97073479	36778416	92	28777											
TCTN1	79600	broad.mit.edu	37	chr12	111078916	111078916	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggacagttagcagcgtagtgGtcccactgcagcaaaagttt	11	9	12	9	1	0	0	0	0	0	0	1	1	1	1	1	2	4	6	1	2	4	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:111078916G>C	uc009zvs.2	+	9	1174	c.1066G>C	c.(1066-1068)GTC>CTC	p.V356L	TCTN1_uc009zvr.1_RNA|TCTN1_uc001trl.2_RNA|TCTN1_uc001trm.2_Missense_Mutation_p.V296L|TCTN1_uc010syc.1_RNA|TCTN1_uc001tro.2_RNA|TCTN1_uc001trp.3_Missense_Mutation_p.V342L|TCTN1_uc001trn.3_Missense_Mutation_p.V356L|TCTN1_uc001trj.1_Missense_Mutation_p.V300L|TCTN1_uc001trk.3_RNA|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	356					multicellular organismal development	extracellular region					0						CAGCGTAGTGGTCCCACTGCA	0.378													16	56					0	0	0	0	C	111078916	C	C	111078916	3	2	155	1	0	0	0	0	1	0	0	0	15788	1261	44	4	1272	4	TCTN1	12	111078916	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	14005437	111078916	22772979	93	28778											
TAOK3	51347	broad.mit.edu	37	chr12	118610455	118610455	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgggtgtgctatggtccTcattcatttcctaaaaagaa	10	15	8	8	0	3	1	2	0	1	1	5	1	5	1	2	2	1	1	2	2	5	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:118610455T>C	uc001twx.2	-	17	2001	c.1706A>G	c.(1705-1707)GAG>GGG	p.E569G	TAOK3_uc001twv.2_Missense_Mutation_p.E109G|TAOK3_uc001tww.2_Missense_Mutation_p.E399G|TAOK3_uc001twy.3_Missense_Mutation_p.E569G	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	569	Potential.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTATGGTCCTCATTCATTTC	0.418													3	138					0	0	0	0	C	118610455	C	C	118610455	3	2	155	1	0	0	0	0	1	0	0	0	15615	1551	54	5	1010	5	TAOK3	12	118610455	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	7531539	118610455	15241440	94	28779											
DDX55	57696	broad.mit.edu	37	chr12	124099831	124099831	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagatgaaatataaacgcaaTaagatcttcatggagttccg	17	10	8	6	2	2	3	1	1	1	2	3	4	3	4	1	1	1	2	1	1	7	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:124099831T>A	uc001ufi.2	+	9	948	c.924T>A	c.(922-924)AAT>AAA	p.N308K	DDX55_uc001ufh.2_Missense_Mutation_p.N161K|DDX55_uc001ufj.1_Missense_Mutation_p.N161K|DDX55_uc001ufk.2_Missense_Mutation_p.N161K	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	308	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		ATAAACGCAATAAGATCTTCA	0.378													9	48					0	0	0	0	A	124099831	A	A	124099831	3	1	155	1	0	0	0	0	1	0	0	0	4390	1403	49	5	958	5	DDX55	12	124099831	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	5489376	124099831	9752064	95	28780											
TMEM132D	121256	broad.mit.edu	37	chr12	129559121	129559121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctaaaaggctttcctggcCtttcttcttctgcaggatgg	7	15	9	10	0	4	0	0	0	4	0	5	1	5	1	2	4	1	2	2	4	2	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:129559121C>T	uc009zyl.1	-	9	2927	c.2599G>A	c.(2599-2601)GGC>AGC	p.G867S	TMEM132D_uc001uia.2_Missense_Mutation_p.G405S	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	867	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CTTTCCTGGCCTTTCTTCTTC	0.567													6	55					0	0	0	0	T	129559121	T	T	129559121	3	4	155	1	0	0	0	0	1	0	0	0	16113	681	24	4	704	4	TMEM132D	12	129559121	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	5459290	129559121	4292774	96	28781											
GPR133	283383	broad.mit.edu	37	chr12	131593399	131593399	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcggaggacagcaagcaccGttactactatgggatgggat	11	8	14	8	2	0	0	0	0	0	0	1	4	0	4	1	4	4	3	1	4	4	3	rs141128784		TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr12:131593399G>A	uc001uit.3	+	18	2577	c.2018G>A	c.(2017-2019)CGT>CAT	p.R673H	GPR133_uc010tbm.1_Missense_Mutation_p.R705H|GPR133_uc009zyo.2_Intron|GPR133_uc001uiv.1_Missense_Mutation_p.R192H|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	673	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		AGCAAGCACCGTTACTACTat	0.299													15	68					0	0	0	0	A	131593399	A	A	131593399	3	1	155	1	0	0	0	0	1	0	0	0	6681	1145	40	1	2088	1	GPR133	12	131593399	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	2034278	131593399	2258496	97	28782											
SLC46A3	283537	broad.mit.edu	37	chr13	29287503	29287503	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcaaaagctggaatggaaagGcaaaatagcaaagcaaacag	21	4	10	6	0	1	0	1	0	0	0	1	2	1	2	0	3	4	4	0	3	9	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr13:29287503G>A	uc001usi.2	-	2	1344	c.374C>T	c.(373-375)GCC>GTC	p.A125V	SLC46A3_uc001usg.2_Missense_Mutation_p.A50V|SLC46A3_uc001usj.2_Missense_Mutation_p.A125V|SLC46A3_uc001ush.2_Missense_Mutation_p.A125V|SLC46A3_uc001usk.2_Missense_Mutation_p.A50V	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	125	Extracellular (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)		GAATGGAAAGGCAAAATAGCA	0.413													6	22					0	0	0	0	A	29287503	A	A	29287503	3	1	155	1	0	0	0	0	1	0	0	0	14710	1203	42	4	1041	4	SLC46A3	13	29287503	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08		29287503	85882375	98	28783											
NBEA	26960	broad.mit.edu	37	chr13	35770345	35770345	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggctgctccagttgaaataGcagaatgtggccctgaacct	10	10	11	10	0	0	3	0	2	0	1	1	3	1	3	3	2	3	4	3	2	4	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr13:35770345G>A	uc001uvb.2	+	31	5478	c.5272G>A	c.(5272-5274)GCA>ACA	p.A1758T	NBEA_uc010abi.2_Missense_Mutation_p.A414T	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1758						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AGTTGAAATAGCAGAATGTGG	0.428													12	44					0	0	0	0	A	35770345	A	A	35770345	3	1	155	1	0	0	0	0	1	0	0	0	10240	971	34	4	5394	4	NBEA	13	35770345	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	6482842	35770345	79399533	99	28784											
FOXO1	2308	broad.mit.edu	37	chr13	41133857	41133857	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttctcctggtggagaaggcCcattctgccatagccattgc	7	11	10	13	0	2	1	0	0	2	1	3	2	2	1	4	3	3	0	4	3	2	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr13:41133857C>T	uc001uxl.3	-	2	2156	c.1771G>A	c.(1771-1773)GGC>AGC	p.G591S	FOXO1_uc010acc.1_Missense_Mutation_p.G406S	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	591					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TGGAGAAGGCCCATTCTGCCA	0.547													22	71					0	0	0	0	T	41133857	T	T	41133857	3	4	155	1	0	0	0	0	1	0	0	0	6057	623	22	4	200	4	FOXO1	13	41133857	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	5363512	41133857	74036021	100	28785											
DIS3	22894	broad.mit.edu	37	chr13	73337680	73337680	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgttcagaaaattcctcaTgaattttttttgcaacagaa	14	15	5	7	0	2	3	2	1	0	2	3	3	3	3	1	0	2	2	1	0	5	6			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr13:73337680T>G	uc001vix.3	-	16	2410	c.2036A>C	c.(2035-2037)CAT>CCT	p.H679P	DIS3_uc001viy.3_Missense_Mutation_p.H649P|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	679					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		AAATTCCTCATGAATTTTTTT	0.368										Multiple Myeloma(4;0.011)			6	32					0	0	0	0	G	73337680	G	G	73337680	3	3	155	1	0	0	0	0	1	0	0	0	4557	1464	51	5	864	5	DIS3	13	73337680	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08	32203823	73337680	41832198	101	28786											
KLF5	688	broad.mit.edu	37	chr13	73636125	73636137	+	Frame_Shift_Del	DEL	TTACCTTACAGTA	-	-																															tcttcactgacactgaagggTtaccttacagtatcaacatg																								rs143426593		TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr13:73636125_73636137delTTACCTTACAGTA	uc001vje.2	+	2	712_724	c.388_400delTTACCTTACAGTA	c.(388-402)TTACCTTACAGTATCfs	p.L130fs	KLF5_uc001vjd.2_Frame_Shift_Del_p.L39fs	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	130_134					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CACTGAAGGGTTACCTTACAGTATCAACATGAA	0.474													---	---	---								-	73636137	-	-	73636125	7	5	155	1	0	1	0	1	0	0	0	0	8388	1722	60	0	394	0	KLF5	13	73636125	Frame_Shift_Del	DEL	TTACCTTACAGTA	TCGA-CR-7389-01A-11D-2012-08	298445	73636125	41533753	102	28787											
TEP1	7011	broad.mit.edu	37	chr14	20845894	20845894	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacggggccgacccagagAccctgaccacacctgaacct	10	3	9	19	2	0	3	0	2	0	1	0	5	0	3	7	2	1	0	7	2	1	0			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr14:20845894A>T	uc001vxe.2	-	40	5780	c.5740T>A	c.(5740-5742)TCT>ACT	p.S1914T	TEP1_uc010ahk.2_Missense_Mutation_p.S1257T|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.S1806T|TEP1_uc010tlh.1_Missense_Mutation_p.S252T	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1914	WD 7.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CGACCCAGAGACCCTGACCAC	0.587													12	46					0	0	0	0	T	20845894	T	T	20845894	3	4	155	1	0	0	0	0	1	0	0	0	15825	275	10	5	2207	5	TEP1	14	20845894	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08		20845894	86503646	103	28788											
C14orf135	64430	broad.mit.edu	37	chr14	60582438	60582438	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctttttgttttgttttagtAtcaccttttgccatgatagc	6	22	6	7	0	2	1	1	1	1	0	2	1	2	1	2	0	2	3	2	0	3	10			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr14:60582438A>G	uc001xer.3	+	4	1179	c.657A>G	c.(655-657)GTA>GTG	p.V219V	C14orf135_uc001xeq.2_Silent_p.V219V|C14orf135_uc010apm.2_5'Flank	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	453	Helical; (Potential).					integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		TTGTTTTAGTATCACCTTTTG	0.343													9	14					0	0	0	0	G	60582438	G	G	60582438	2	3	155	1	0	0	0	0	0	0	0	1	1751	463	16	5		5	C14orf135	14	60582438	Silent	SNP	A	TCGA-CR-7389-01A-11D-2012-08	39736544	60582438	46767102	104	28789											
SERPINA4	5267	broad.mit.edu	37	chr14	95033317	95033317	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcccttcagccctgtgggaGaaaccattcatttcctcaag	9	12	7	13	0	3	1	3	0	0	1	5	2	5	1	4	1	2	0	4	1	2	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr14:95033317G>A	uc001ydk.2	+	3	726	c.660G>A	c.(658-660)GAG>GAA	p.E220E	SERPINA4_uc010avd.2_Silent_p.E257E|SERPINA4_uc001ydl.2_Silent_p.E220E	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	220					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		CCCTGTGGGAGAAACCATTCA	0.517													16	121					0	0	0	0	A	95033317	A	A	95033317	2	1	155	1	0	0	0	0	0	0	0	1	14156	933	33	2		2	SERPINA4	14	95033317	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	34450879	95033317	12316223	105	28790											
GPR132	29933	broad.mit.edu	37	chr14	105517549	105517549	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatggtccgtggccagcaCgtagataatggggtcagcca	10	7	15	9	2	1	1	1	0	0	1	2	2	2	2	3	5	2	2	3	5	3	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr14:105517549C>T	uc001yqd.2	-	4	1824	c.925G>A	c.(925-927)GTG>ATG	p.V309M	GPR132_uc001yqc.2_Missense_Mutation_p.V121M|GPR132_uc001yqe.2_Missense_Mutation_p.V300M	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	309	Helical; Name=7; (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		GTGGCCAGCACGTAGATAATG	0.577													34	34					0	0	0	0	T	105517549	T	T	105517549	3	4	155	1	0	0	0	0	1	0	0	0	6680	536	19	1	221	1	GPR132	14	105517549	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	10484232	105517549	1831991	106	28791											
CAPN3	825	broad.mit.edu	37	chr15	42701996	42701996	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcctcaggacatggagatCtgtgcagatgagctcaagaa	12	8	11	10	0	3	4	2	1	1	3	4	6	4	5	2	2	2	2	2	2	2	0			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr15:42701996C>T	uc001zpn.1	+	18	2310	c.2004C>T	c.(2002-2004)ATC>ATT	p.I668I	CAPN3_uc001zpk.1_Silent_p.I435I|CAPN3_uc001zpl.1_Silent_p.I575I|CAPN3_uc010udf.1_Silent_p.I581I|CAPN3_uc010udg.1_Silent_p.I533I|CAPN3_uc001zpo.1_Silent_p.I662I|CAPN3_uc001zpp.1_Silent_p.I576I|CAPN3_uc001zpq.1_Silent_p.I156I|CAPN3_uc010bcv.1_Silent_p.I3I|CAPN3_uc001zpr.1_Silent_p.I3I|CAPN3_uc001zps.1_Silent_p.I3I|CAPN3_uc001zpt.1_Silent_p.I3I	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	668	EF-hand 1.|Domain IV.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		ACATGGAGATCTGTGCAGATG	0.542													29	111					0	0	0	0	T	42701996	T	T	42701996	2	4	155	1	0	0	0	0	0	0	0	1	2640	903	32	2		2	CAPN3	15	42701996	Silent	SNP	C	TCGA-CR-7389-01A-11D-2012-08		42701996	59829396	107	28792											
UNC13C	440279	broad.mit.edu	37	chr15	54305623	54305623	+	Frame_Shift_Del	DEL	G	-	-																															acggggagcgtactctacatGgcttaaaactgggagcttta																										TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr15:54305623delG	uc002ack.2	+	1	523	c.523delG	c.(523-525)GGCfs	p.G175fs		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	175					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TACTCTACATGGCTTAAAACT	0.473													---	---	---								-	54305623	-	-	54305623	7	5	155	1	0	1	0	1	0	0	0	0	17054	1348	47	0	525	0	UNC13C	15	54305623	Frame_Shift_Del	DEL	G	TCGA-CR-7389-01A-11D-2012-08	11603627	54305623	48225769	108	28793											
DPP8	54878	broad.mit.edu	37	chr15	65759441	65759441	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaagaatgtgagtagccacGgtcagtcagccttgtcacct	10	9	11	11	1	3	2	3	1	0	1	3	2	3	2	3	1	2	2	3	1	3	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr15:65759441G>A	uc002aov.2	-	13	3283	c.1705C>T	c.(1705-1707)CGT>TGT	p.R569C	DPP8_uc002aow.2_Missense_Mutation_p.R569C|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Missense_Mutation_p.R553C|DPP8_uc002aoy.2_Missense_Mutation_p.R569C|DPP8_uc002aoz.2_Missense_Mutation_p.R553C|DPP8_uc010bhj.2_Missense_Mutation_p.R569C|DPP8_uc002apa.2_Missense_Mutation_p.R466C|DPP8_uc010bhi.2_5'UTR|DPP8_uc010bhk.1_Missense_Mutation_p.R138C	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	569					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						GAGTAGCCACGGTCAGTCAGC	0.413													5	34					0	0	0	0	A	65759441	A	A	65759441	3	1	155	1	0	0	0	0	1	0	0	0	4754	1116	39	1	1023	1	DPP8	15	65759441	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	11453818	65759441	36771951	109	28794											
ACSBG1	23205	broad.mit.edu	37	chr15	78474320	78474320	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagactgaccttcagggcGtcgggttcggcaaagcaaac	10	6	14	11	3	1	2	1	1	0	1	3	2	1	2	1	4	2	4	1	4	2	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr15:78474320G>A	uc002bdh.2	-	8	1118	c.1062C>T	c.(1060-1062)GAC>GAT	p.D354D	ACSBG1_uc010umw.1_Silent_p.D350D|ACSBG1_uc010umx.1_Silent_p.D112D|ACSBG1_uc010umy.1_Silent_p.D247D	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	354					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						CCTTCAGGGCGTCGGGTTCGG	0.607													22	33					0	0	0	0	A	78474320	A	A	78474320	2	1	155	1	0	0	0	0	0	0	0	1	173	1136	40	1		1	ACSBG1	15	78474320	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	12714879	78474320	24057072	110	28795											
HPR	3250	broad.mit.edu	37	chr16	72110789	72110789	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaccttctgtgtcggcatgTctaagtaccaggaagacacc	11	9	9	12	1	2	1	0	0	2	1	3	2	2	2	3	2	1	2	3	2	3	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr16:72110789T>C	uc002fby.2	+	5	886	c.856T>C	c.(856-858)TCT>CCT	p.S286P	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	286	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				TGTCGGCATGTCTAAGTACCA	0.567													7	87					0	0	0	0	C	72110789	C	C	72110789	3	2	155	1	0	0	0	0	1	0	0	0	7376	1667	58	5	874	5	HPR	16	72110789	Missense_Mutation	SNP	T	TCGA-CR-7389-01A-11D-2012-08		72110789	18243964	111	28796											
DNAH9	1770	broad.mit.edu	37	chr17	11607668	11607668	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcaccatgctgattggccAgctctccaagggagaccggc	9	8	11	13	1	2	2	1	1	1	1	3	3	2	2	4	3	2	2	4	3	2	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr17:11607668A>G	uc002gne.2	+	25	5368	c.5300A>G	c.(5299-5301)CAG>CGG	p.Q1767R	DNAH9_uc010coo.2_Missense_Mutation_p.Q1061R	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1767	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTGATTGGCCAGCTCTCCAAG	0.517													4	68					0	0	0	0	G	11607668	G	G	11607668	3	3	155	1	0	0	0	0	1	0	0	0	4630	188	7	5	5398	5	DNAH9	17	11607668	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08		11607668	69587542	112	28797											
SLC46A1	113235	broad.mit.edu	37	chr17	26731995	26731995	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgacggaacgtgaagagccgGgtggactttggctcctttaa	9	10	14	8	3	0	3	0	2	0	1	1	5	1	5	2	4	2	1	2	4	3	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr17:26731995G>A	uc002hbf.1	-	2	816	c.720C>T	c.(718-720)ACC>ACT	p.T240T	SLC46A1_uc002hbg.1_Silent_p.T240T|SLC46A1_uc010wak.1_Silent_p.T240T	NM_080669	NP_542400	Q96NT5	PCFT_HUMAN	proton-coupled folate transporter	240					cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	TGAAGAGCCGGGTGGACTTTG	0.547													6	125					0	0	0	0	A	26731995	A	A	26731995	2	1	155	1	0	0	0	0	0	0	0	1	14708	1219	43	4		4	SLC46A1	17	26731995	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	15124327	26731995	54463215	113	28798											
COLEC12	81035	broad.mit.edu	37	chr18	347016	347016	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggttgttgaggttcatgatGaccacattatgagaatacat	13	13	10	5	0	1	4	1	4	0	1	1	5	1	4	1	2	1	3	1	2	3	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr18:347016G>A	uc002kkm.2	-	5	821	c.606C>T	c.(604-606)GTC>GTT	p.V202V		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	202	Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GGTTCATGATGACCACATTAT	0.507													5	125					0	0	0	0	A	347016	A	A	347016	2	1	155	1	0	0	0	0	0	0	0	1	3727	1277	45	2		2	COLEC12	18	347016	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08		347016	77730232	114	28799											
MC5R	4161	broad.mit.edu	37	chr18	13826399	13826399	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catacacatgttcctcctggCgcggactcacgtcaagcgga	9	8	10	14	4	2	0	2	0	0	0	4	2	4	2	2	3	2	1	2	3	2	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr18:13826399C>T	uc010xaf.1	+	1	635	c.635C>T	c.(634-636)GCG>GTG	p.A212V		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	212	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						TTCCTCCTGGCGCGGACTCAC	0.612													23	315					0	0	0	0	T	13826399	T	T	13826399	3	4	155	1	0	0	0	0	1	0	0	0	9420	768	27	1	637	1	MC5R	18	13826399	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	13479383	13826399	64250849	115	28800											
DCC	1630	broad.mit.edu	37	chr18	50278466	50278466	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcactgcgcttcctctcagAaccttctgatgccgtcacaa	9	10	7	15	2	3	2	2	1	2	1	5	2	4	2	3	0	4	2	3	0	2	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr18:50278466A>C	uc002lfe.1	+	2	721	c.134A>C	c.(133-135)GAA>GCA	p.E45A	DCC_uc010xdr.1_5'UTR	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	45	Extracellular (Potential).|Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TTCCTCTCAGAACCTTCTGAT	0.483													3	31					0	0	0	0	C	50278466	C	C	50278466	3	2	155	1	0	0	0	0	1	0	0	0	4299	246	9	5	140	5	DCC	18	50278466	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	36452067	50278466	27798782	116	28801											
KIAA1468	57614	broad.mit.edu	37	chr18	59928749	59928749	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccttatgtttcaggaaggAgaacatggactggatgaaca	13	10	11	7	0	1	2	1	1	0	1	2	6	2	5	1	4	2	1	1	4	4	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr18:59928749A>G	uc002lil.2	+	16	2423	c.2208A>G	c.(2206-2208)GGA>GGG	p.G736G	KIAA1468_uc002lik.1_Silent_p.G736G|KIAA1468_uc010xel.1_Silent_p.G736G|KIAA1468_uc002lim.2_Silent_p.G380G	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	736							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				TTCAGGAAGGAGAACATGGAC	0.393													9	44					0	0	0	0	G	59928749	G	G	59928749	2	3	155	1	0	0	0	0	0	0	0	1	8275	291	11	5		5	KIAA1468	18	59928749	Silent	SNP	A	TCGA-CR-7389-01A-11D-2012-08	9650283	59928749	18148499	117	28802											
MAST3	23031	broad.mit.edu	37	chr19	18235532	18235532	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccaaggcattaagactgaCcttccacagtacatcattgg	12	9	9	11	0	1	2	1	1	0	1	2	2	2	2	3	3	1	2	3	3	3	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr19:18235532C>T	uc002nhz.3	+	10	939	c.939C>T	c.(937-939)GAC>GAT	p.D313D		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	313							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						TTAAGACTGACCTTCCACAGT	0.617													4	35					0	0	0	0	T	18235532	T	T	18235532	2	4	155	1	0	0	0	0	0	0	0	1	9379	506	18	4		4	MAST3	19	18235532	Silent	SNP	C	TCGA-CR-7389-01A-11D-2012-08		18235532	40893451	118	28803											
RASGRP4	115727	broad.mit.edu	37	chr19	38912750	38912750	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcggcgcacttggcggggccGgcctcgccctcctatttttc	2	10	13	16	5	0	0	0	0	0	0	3	0	1	0	4	5	0	1	4	5	1	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr19:38912750G>A	uc002oir.2	-	2	281	c.67C>T	c.(67-69)CGG>TGG	p.R23W	RASGRP4_uc010efz.1_5'Flank|RASGRP4_uc010ega.1_5'Flank|RASGRP4_uc010xua.1_Missense_Mutation_p.R23W|RASGRP4_uc010xub.1_Missense_Mutation_p.R23W|RASGRP4_uc010xuc.1_Missense_Mutation_p.R23W|RASGRP4_uc010xud.1_Missense_Mutation_p.R23W|RASGRP4_uc010xue.1_Missense_Mutation_p.R23W|RASGRP4_uc010egb.2_Missense_Mutation_p.R23W	NM_170604	NP_733749	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4 isoform a	23					activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			pancreas(1)|lung(1)|skin(1)	3	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGGCGGGGCCGGCCTCGCCCT	0.627													20	33					0	0	0	0	A	38912750	A	A	38912750	3	1	155	1	0	0	0	0	1	0	0	0	13142	1115	39	1	2018	1	RASGRP4	19	38912750	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	20677218	38912750	20216233	119	28804											
MEGF8	1954	broad.mit.edu	37	chr19	42873017	42873017	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgacatgtgggcgtccgggGgcctcctgggccttcctgtc	2	10	15	14	2	0	1	0	1	0	0	4	1	3	1	5	4	0	0	5	4	0	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr19:42873017G>A	uc002otl.3	+	36	6938	c.6303G>A	c.(6301-6303)GGG>GGA	p.G2101G	MEGF8_uc002otm.3_Silent_p.G1709G|MEGF8_uc002otn.3_5'Flank	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2168	Extracellular (Potential).|PSI 7.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GGCGTCCGGGGGCCTCCTGGG	0.647													36	63					0	0	0	0	A	42873017	A	A	42873017	2	1	155	1	0	0	0	0	0	0	0	1	9516	1219	43	4		4	MEGF8	19	42873017	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	3960267	42873017	16255966	120	28805											
ZNF227	7770	broad.mit.edu	37	chr19	44739552	44739552	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatcatacaggagagaagtcTtatagatgcgacagttgcgg	14	9	12	6	2	2	2	1	0	1	2	2	5	2	3	0	2	3	1	0	2	5	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr19:44739552T>C	uc002oyu.2	+	6	1174	c.969T>C	c.(967-969)TCT>TCC	p.S323S	ZNF227_uc010xwu.1_Silent_p.S272S|ZNF227_uc002oyv.2_Silent_p.S323S|ZNF227_uc010xwv.1_Silent_p.S272S|ZNF227_uc010xww.1_Silent_p.S244S|ZNF227_uc002oyw.2_Silent_p.S295S|ZNF227_uc010ejh.2_Silent_p.S316S|ZNF235_uc002oyx.1_Intron	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	323					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				GAGAGAAGTCTTATAGATGCG	0.403													7	72					0	0	0	0	C	44739552	C	C	44739552	2	2	155	1	0	0	0	0	0	0	0	1	17848	1596	56	5		5	ZNF227	19	44739552	Silent	SNP	T	TCGA-CR-7389-01A-11D-2012-08	1866535	44739552	14389431	121	28806											
ZNF229	7772	broad.mit.edu	37	chr19	44933969	44933969	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgcgtgttctgtctgacGccccgaccacgctcaagact	7	10	10	14	4	3	2	1	1	2	1	3	3	3	2	3	0	1	2	3	0	1	1			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr19:44933969G>A	uc002oze.1	-	6	1421	c.987C>T	c.(985-987)GGC>GGT	p.G329G	ZNF229_uc010ejk.1_5'UTR|ZNF229_uc010ejl.1_Silent_p.G323G	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				TCTGTCTGACGCCCCGACCAC	0.507													7	77					0	0	0	0	A	44933969	A	A	44933969	2	1	155	1	0	0	0	0	0	0	0	1	17849	1074	38	1		1	ZNF229	19	44933969	Silent	SNP	G	TCGA-CR-7389-01A-11D-2012-08	194417	44933969	14195014	122	28807											
SAE1	10055	broad.mit.edu	37	chr19	47673077	47673077	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgccttttttccacagaaGgtggtcttctgccctgttaa	6	16	8	11	0	3	1	0	0	3	1	4	1	4	1	3	2	2	1	3	2	2	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr19:47673077G>C	uc002pgc.2	+	6	686	c.630G>C	c.(628-630)AAG>AAC	p.K210N	SAE1_uc002pgd.2_Missense_Mutation_p.K210N|SAE1_uc010ekx.2_Missense_Mutation_p.K210N|SAE1_uc010ekw.2_RNA|SAE1_uc010xyk.1_Missense_Mutation_p.K36N|SAE1_uc002pge.2_Missense_Mutation_p.K146N	NM_016402	NP_057486	Q9UBE0	SAE1_HUMAN	SubName: Full=SUMO-1 activating enzyme subunit 1, isoform CRA_b; SubName: Full=cDNA, FLJ96708, Homo sapiens SUMO-1 activating enzyme subunit 1 (SAE1), mRNA;	210					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			ovary(1)	1		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		TTCCACAGAAGGTGGTCTTCT	0.463													42	107					0	0	0	0	C	47673077	C	C	47673077	3	2	155	1	0	0	0	0	1	0	0	0	13870	991	35	4	652	4	SAE1	19	47673077	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	2739108	47673077	11455906	123	28808											
PPFIA3	8541	broad.mit.edu	37	chr19	49643025	49643025	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgctctgcccgtcttgagaGaatgacccaggccttggcac	7	8	11	15	2	2	3	0	2	2	1	2	4	2	3	4	2	1	2	4	2	1	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr19:49643025G>C	uc002pmr.2	+	17	2509	c.2177G>C	c.(2176-2178)AGA>ACA	p.R726T	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Missense_Mutation_p.R594T	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	726						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CGTCTTGAGAGAATGACCCAG	0.652													3	57					0	0	0	0	C	49643025	C	C	49643025	3	2	155	1	0	0	0	0	1	0	0	0	12366	942	33	2	2239	2	PPFIA3	19	49643025	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	1969948	49643025	9485958	124	28809											
ZNF671	79891	broad.mit.edu	37	chr19	58234695	58234695	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtatacaaacacatcctcaAagaccacacagccctgcaac	17	5	4	15	0	1	1	1	0	0	1	2	1	2	1	3	0	5	2	3	0	5	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr19:58234695A>G	uc002qpz.3	-	2	251	c.152T>C	c.(151-153)TTT>TCT	p.F51S	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_5'UTR|ZNF671_uc010yhf.1_Intron	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	51	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CACATCCTCAAAGACCACACA	0.453													33	128					0	0	0	0	G	58234695	G	G	58234695	3	3	155	1	0	0	0	0	1	0	0	0	18145	14	1	5	1464	5	ZNF671	19	58234695	Missense_Mutation	SNP	A	TCGA-CR-7389-01A-11D-2012-08	8591670	58234695	894288	125	28810											
HAO1	54363	broad.mit.edu	37	chr20	7886819	7886819	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctctcaaaatgccctttgCaacaattggcaatgatgtca	13	11	6	11	0	2	1	2	1	1	0	3	1	2	1	2	1	3	2	2	1	5	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr20:7886819C>T	uc002wmw.1	-	4	727	c.703G>A	c.(703-705)GCA>ACA	p.A235T	HAO1_uc010gbu.2_Missense_Mutation_p.A235T	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	235	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						ATGCCCTTTGCAACAATTGGC	0.383													26	73					0	0	0	0	T	7886819	T	T	7886819	3	4	155	1	0	0	0	0	1	0	0	0	6990	710	25	4	429	4	HAO1	20	7886819	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08		7886819	55138701	126	28811											
CDC45	8318	broad.mit.edu	37	chr22	19467525	19467525	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atttccgcaaagagttctacGaggtggtccagagccaggtg	10	9	13	9	2	1	2	0	0	1	2	3	3	3	2	3	3	2	2	3	3	2	3			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr22:19467525G>A	uc002zpr.2	+	1	110	c.34G>A	c.(34-36)GAG>AAG	p.E12K	UFD1L_uc002zpm.2_5'Flank|UFD1L_uc002zpo.2_5'Flank|UFD1L_uc011agy.1_5'Flank|UFD1L_uc002zpp.2_5'Flank|UFD1L_uc010grq.2_5'Flank|CDC45_uc011agz.1_Missense_Mutation_p.E12K|CDC45_uc011aha.1_Missense_Mutation_p.E12K|CDC45_uc002zps.2_Missense_Mutation_p.E12K|CDC45_uc002zpt.2_Missense_Mutation_p.E12K	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	12					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						AGAGTTCTACGAGGTGGTCCA	0.692													6	149					0	0	0	0	A	19467525	A	A	19467525	3	1	155	1	0	0	0	0	1	0	0	0	3096	1059	37	1	36	1	CDC45	22	19467525	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08		19467525	31837041	127	28812											
CDC45	8318	broad.mit.edu	37	chr22	19471460	19471460	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcttcagggatgaagaggagGatgaagagcattcaggaaat	15	8	14	4	0	3	4	2	2	1	2	3	8	3	8	0	4	1	1	0	4	3	2	rs61752240	byFrequency	TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr22:19471460G>A	uc002zpr.2	+	5	494	c.418G>A	c.(418-420)GAT>AAT	p.D140N	CDC45_uc011agz.1_Missense_Mutation_p.D135N|CDC45_uc011aha.1_Missense_Mutation_p.D140N|CDC45_uc002zps.2_Missense_Mutation_p.D140N|CDC45_uc002zpt.2_Missense_Mutation_p.D94N	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	140					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						TGAAGAGGAGGATGAAGAGCA	0.433													7	83					0	0	0	0	A	19471460	A	A	19471460	3	1	155	1	0	0	0	0	1	0	0	0	3096	1174	41	2	436	2	CDC45	22	19471460	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08	3935	19471460	31833106	128	28813											
CACNA1I	8911	broad.mit.edu	37	chr22	40066099	40066099	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatctccttcctgctcatCgtcagcttctttgtgctcaa	5	17	5	14	1	6	0	4	0	2	0	9	0	7	0	2	0	3	3	2	0	1	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr22:40066099C>A	uc003ayc.2	+	25	4251	c.4251C>A	c.(4249-4251)ATC>ATA	p.I1417I	CACNA1I_uc003ayd.2_Silent_p.I1382I|CACNA1I_uc003aye.2_Silent_p.I1332I|CACNA1I_uc003ayf.2_Silent_p.I1297I	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1417	Helical; Name=S6 of repeat III; (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TCCTGCTCATCGTCAGCTTCT	0.582													17	316					5.3912e-06	1.90389e-05	1	0	A	40066099	A	A	40066099	2	1	155	1	0	0	0	0	0	0	0	1	2558	874	31	3		3	CACNA1I	22	40066099	Silent	SNP	C	TCGA-CR-7389-01A-11D-2012-08	20594639	40066099	11238467	129	28814											
FAM118A	55007	broad.mit.edu	37	chr22	45728337	45728337	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaacttataccgcaccaagtCctttctgtttgtgggctgtg	7	14	10	10	1	1	0	0	0	1	0	2	1	2	0	3	1	2	3	3	1	4	4			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr22:45728337C>G	uc003bfz.3	+	7	1299	c.683C>G	c.(682-684)TCC>TGC	p.S228C	FAM118A_uc003bga.3_Missense_Mutation_p.S228C|FAM118A_uc011aqr.1_Missense_Mutation_p.S46C	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	228						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CGCACCAAGTCCTTTCTGTTT	0.463													13	188					0	0	0	0	G	45728337	G	G	45728337	3	3	155	1	0	0	0	0	1	0	0	0	5439	855	30	2	701	2	FAM118A	22	45728337	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	5662238	45728337	5576229	130	28815											
TTLL8	164714	broad.mit.edu	37	chr22	50470327	50470327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaagctgttcttgcgaggctCcacgtggtcctgggccacct	6	10	12	13	2	1	0	0	0	1	0	3	1	3	0	4	3	2	3	4	3	1	2			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chr22:50470327C>T	uc011ark.1	-	11	1495	c.1495G>A	c.(1495-1497)GAG>AAG	p.E499K		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		TTGCGAGGCTCCACGTGGTCC	0.637													6	40					0	0	0	0	T	50470327	T	T	50470327	3	4	155	1	0	0	0	0	1	0	0	0	16801	864	30	2	1024	2	TTLL8	22	50470327	Missense_Mutation	SNP	C	TCGA-CR-7389-01A-11D-2012-08	4741990	50470327	834239	131	28816											
NAP1L3	4675	broad.mit.edu	37	chrX	92927421	92927421	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccttcctagctcttttaaGatctacactgtcctgaagcc	8	14	5	14	0	2	2	0	1	2	1	5	2	5	2	4	0	3	1	4	0	4	5			TCGA-CR-7389-01A-11D-2012-08	TCGA-CR-7389-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	37149937-8131-4dbf-916b-d599d203eba7	16849673-1fb6-4726-84df-7804bdc10e3f	g.chrX:92927421G>T	uc004efq.2	-	1	1188	c.883C>A	c.(883-885)CTT>ATT	p.L295I	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	295					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						GCTCTTTTAAGATCTACACTG	0.433													32	19					7.16923e-06	2.51421e-05	1	0	T	92927421	T	T	92927421	3	4	155	1	0	0	0	0	1	0	0	0	10211	942	33	2	641	2	NAP1L3	23	92927421	Missense_Mutation	SNP	G	TCGA-CR-7389-01A-11D-2012-08		92927421	62343139	132	28817											
PRDM16	63976	broad.mit.edu	37	chr1	3319474	3319474	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgctctacgagggcctggctGaggagctcaagcccgagggc	7	5	16	13	3	2	1	1	1	1	0	2	4	2	2	2	4	3	3	2	4	2	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:3319474G>A	uc001akf.2	+	6	876	c.796G>A	c.(796-798)GAG>AAG	p.E266K	PRDM16_uc001akc.2_Missense_Mutation_p.E266K|PRDM16_uc001akd.2_Missense_Mutation_p.E266K|PRDM16_uc001ake.2_Missense_Mutation_p.E266K|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	266					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GGGCCTGGCTGAGGAGCTCAA	0.637			T	EVI1	MDS|AML								17	60					0	0	0	0	A	3319474	A	A	3319474	3	1	156	1	0	0	0	0	1	0	0	0	12519	1291	45	2	818	2	PRDM16	1	3319474	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08		3319474	245931147	1	28818											
PER3	8863	broad.mit.edu	37	chr1	7848168	7848168	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcacatttctgaacaggctGctttgatcctgaatcgtaag	10	13	9	9	1	1	3	0	3	1	0	3	3	2	3	1	1	3	4	1	1	3	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:7848168G>T	uc001aoo.2	+	4	629	c.454G>T	c.(454-456)GCT>TCT	p.A152S	PER3_uc009vmg.1_Missense_Mutation_p.A152S|PER3_uc009vmh.1_Missense_Mutation_p.A152S|PER3_uc001aop.2_Missense_Mutation_p.A152S|PER3_uc010nzw.1_5'UTR|PER3_uc001aon.2_Missense_Mutation_p.A152S	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	152	PAS 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TGAACAGGCTGCTTTGATCCT	0.413													24	107					2.48779e-11	1.04604e-10	1	0	T	7848168	T	T	7848168	3	4	156	1	0	0	0	0	1	0	0	0	11785	1319	46	4	468	4	PER3	1	7848168	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	4528694	7848168	241402453	2	28819											
TESK2	10420	broad.mit.edu	37	chr1	45923296	45923296	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtgaaatcatccaaacgCgtcagtctggaaaaggcact	14	7	10	10	2	3	1	2	1	1	0	4	2	4	2	1	3	1	1	1	3	4	0			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:45923296C>T	uc001cns.1	-	2	565	c.162G>A	c.(160-162)ACG>ACA	p.T54T	TESK2_uc009vxr.1_Silent_p.T54T|TESK2_uc010olo.1_Intron|TESK2_uc009vxs.1_5'UTR|TESK2_uc010olp.1_Silent_p.T54T	NM_007170	NP_009101	Q96S53	TESK2_HUMAN	testis-specific protein kinase 2	54					actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)					CATCCAAACGCGTCAGTCTGG	0.453													14	59					0	0	0	0	T	45923296	T	T	45923296	2	4	156	1	0	0	0	0	0	0	0	1	15834	755	27	1		1	TESK2	1	45923296	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	38075128	45923296	203327325	3	28820											
ZFYVE9	9372	broad.mit.edu	37	chr1	52703916	52703916	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatctcatcccagggaacagAtggatgtcctgctgttaaaa	13	10	9	9	0	1	1	1	0	1	1	4	3	3	3	2	2	2	2	2	2	4	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:52703916A>T	uc001cto.2	+	4	999	c.827A>T	c.(826-828)GAT>GTT	p.D276V	ZFYVE9_uc001ctn.2_Missense_Mutation_p.D276V|ZFYVE9_uc001ctp.2_Missense_Mutation_p.D276V	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	276					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						CAGGGAACAGATGGATGTCCT	0.443													40	194					0	0	0	0	T	52703916	T	T	52703916	3	4	156	1	0	0	0	0	1	0	0	0	17738	333	12	5	833	5	ZFYVE9	1	52703916	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	6780620	52703916	196546705	4	28821											
DOCK7	85440	broad.mit.edu	37	chr1	63005304	63005304	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaagaatgcaaggcttgtaTtgagtctctcaaccatttct	12	13	8	8	0	3	2	1	1	2	1	4	3	3	2	1	1	2	3	1	1	5	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:63005304T>C	uc001daq.2	-	27	3246	c.3212A>G	c.(3211-3213)AAT>AGT	p.N1071S	DOCK7_uc001dan.2_Missense_Mutation_p.N932S|DOCK7_uc001dao.2_Missense_Mutation_p.N932S|DOCK7_uc001dap.2_Missense_Mutation_p.N1040S|DOCK7_uc001dam.2_Missense_Mutation_p.N251S	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1071					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AAGGCTTGTATTGAGTCTCTC	0.343													17	77					0	0	0	0	C	63005304	C	C	63005304	3	2	156	1	0	0	0	0	1	0	0	0	4714	1493	52	5	3306	5	DOCK7	1	63005304	Missense_Mutation	SNP	T	TCGA-CR-7390-01A-11D-2012-08	10301388	63005304	186245317	5	28822											
RABGGTB	5876	broad.mit.edu	37	chr1	76257189	76257189	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaaaaggcaatcgaatttgTtttatcctgtatgaactttg	12	15	9	5	1	0	1	0	1	0	0	2	3	1	2	1	2	1	3	1	2	7	5			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:76257189T>C	uc001dgy.1	+	6	583	c.512T>C	c.(511-513)GTT>GCT	p.V171A	RABGGTB_uc009wbt.1_RNA|RABGGTB_uc001dha.1_Missense_Mutation_p.V125A|RABGGTB_uc001dhc.1_5'Flank	NM_004582	NP_004573	P53611	PGTB2_HUMAN	RAB geranylgeranyltransferase, beta subunit	171	PFTB 4.				protein modification process|visual perception		metal ion binding|protein binding|Rab geranylgeranyltransferase activity			ovary(1)	1						ATCGAATTTGTTTTATCCTGT	0.383													19	70					0	0	0	0	C	76257189	C	C	76257189	3	2	156	1	0	0	0	0	1	0	0	0	13033	1725	60	5	534	5	RABGGTB	1	76257189	Missense_Mutation	SNP	T	TCGA-CR-7390-01A-11D-2012-08	13251885	76257189	172993432	6	28823											
NEXN	91624	broad.mit.edu	37	chr1	78395180	78395180	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaggcgtttgctgaagcaagGagaaatatggtaagacagaa	17	7	13	4	1	0	4	0	1	0	3	0	5	0	4	0	3	2	4	0	3	7	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:78395180G>C	uc001dic.3	+	9	1341	c.1044G>C	c.(1042-1044)AGG>AGC	p.R348S	NEXN_uc001dia.3_Missense_Mutation_p.R334S|NEXN_uc009wcb.1_Missense_Mutation_p.R270S|NEXN_uc001dib.3_Missense_Mutation_p.R284S|NEXN_uc001did.1_Missense_Mutation_p.R258S|NEXN_uc001dif.1_Missense_Mutation_p.R240S	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	348	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		CTGAAGCAAGGAGAAATATGG	0.199													14	63					0	0	0	0	C	78395180	C	C	78395180	3	2	156	1	0	0	0	0	1	0	0	0	10409	1165	41	2	1074	2	NEXN	1	78395180	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	2137991	78395180	170855441	7	28824											
COL11A1	1301	broad.mit.edu	37	chr1	103488537	103488537	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atattcttcagtaaatatttCttcaactggatttggctatt	11	19	5	6	0	4	0	2	0	2	0	4	1	4	1	0	2	1	2	0	2	6	10			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:103488537C>G	uc001dul.2	-	8	1324	c.1006G>C	c.(1006-1008)GAA>CAA	p.E336Q	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.E348Q|COL11A1_uc001dun.2_Missense_Mutation_p.E297Q|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	336	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTAAATATTTCTTCAACTGGA	0.318													11	42					0	0	0	0	G	103488537	G	G	103488537	3	3	156	1	0	0	0	0	1	0	0	0	3682	922	32	2	4654	2	COL11A1	1	103488537	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	25093357	103488537	145762084	8	28825											
RBM15	64783	broad.mit.edu	37	chr1	110882111	110882111	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgtgtgaaacgagcgcgggGcggcgggttactcagctccg	6	7	17	11	6	1	1	1	1	0	0	2	2	2	1	1	4	4	2	1	4	2	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:110882111G>A	uc001dzl.1	+	1	167	c.84G>A	c.(82-84)GGG>GGA	p.G28G	RBM15_uc001dzm.1_Silent_p.G28G|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	28					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGAGCGCGGGGCGGCGGGTTA	0.662			T	MKL1	acute megakaryocytic leukemia								6	22					0	0	0	0	A	110882111	A	A	110882111	2	1	156	1	0	0	0	0	0	0	0	1	13181	1190	42	4		4	RBM15	1	110882111	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	7393574	110882111	138368510	9	28826											
SETDB1	9869	broad.mit.edu	37	chr1	150923394	150923394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcctttttactatattttgGacatcacttatgggaaggaa	12	15	8	6	0	1	0	1	0	0	0	1	3	1	3	1	3	2	0	1	3	6	8			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:150923394G>A	uc001evu.2	+	13	2231	c.2041G>A	c.(2041-2043)GAC>AAC	p.D681N	SETDB1_uc009wmf.2_Missense_Mutation_p.D682N|SETDB1_uc001evv.2_Missense_Mutation_p.D681N|SETDB1_uc009wmg.1_Missense_Mutation_p.D681N	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	681					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTATATTTTGGACATCACTTA	0.478													14	80					0	0	0	0	A	150923394	A	A	150923394	3	1	156	1	0	0	0	0	1	0	0	0	14203	1174	41	2	2087	2	SETDB1	1	150923394	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	40041283	150923394	98327227	10	28827											
UBAP2L	9898	broad.mit.edu	37	chr1	154229858	154229858	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccctcctggggtcccgcCgttgttgcctaatccgtata	4	12	9	16	3	0	0	0	0	0	0	4	0	4	0	7	2	1	3	7	2	3	5			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:154229858C>T	uc001fep.3	+	20	2557	c.2390C>T	c.(2389-2391)CCG>CTG	p.P797L	UBAP2L_uc009wot.2_Missense_Mutation_p.P797L|UBAP2L_uc010pek.1_Missense_Mutation_p.P789L|UBAP2L_uc010pel.1_Missense_Mutation_p.P807L|UBAP2L_uc010pen.1_Missense_Mutation_p.P711L|UBAP2L_uc001feq.2_5'UTR|UBAP2L_uc001fer.2_5'UTR	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	797					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGGGTCCCGCCGTTGTTGCCT	0.473													14	77					0	0	0	0	T	154229858	T	T	154229858	3	4	156	1	0	0	0	0	1	0	0	0	16906	652	23	1	2464	1	UBAP2L	1	154229858	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	3306464	154229858	95020763	11	28828											
FLAD1	80308	broad.mit.edu	37	chr1	154962050	154962050	+	Frame_Shift_Del	DEL	A	-	-																															tggcagggtcttctttggggAaaaaggtggcaggtgcccta																										TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:154962050delA	uc001fgf.1	+	3	1486	c.1132delA	c.(1132-1134)AAAfs	p.K378fs	FLAD1_uc001fgd.1_Frame_Shift_Del_p.K378fs|FLAD1_uc001fge.1_Frame_Shift_Del_p.K281fs|FLAD1_uc001fgg.1_Frame_Shift_Del_p.K281fs|FLAD1_uc001fgh.1_Intron	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	378					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTCTTTGGGGAAAAAGGTGGC	0.488													---	---	---								-	154962050	-	-	154962050	7	5	156	1	0	1	0	1	0	0	0	0	5952	247	9	0	1282	0	FLAD1	1	154962050	Frame_Shift_Del	DEL	A	TCGA-CR-7390-01A-11D-2012-08	732192	154962050	94288571	12	28829											
FCRL1	115350	broad.mit.edu	37	chr1	157773648	157773648	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactcactgtgcacatttatCtgggatctcctgctcctcaa	8	13	6	14	0	4	0	2	0	2	0	6	1	5	1	2	1	2	2	2	1	2	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:157773648C>T	uc001frg.2	-	3	419	c.306G>A	c.(304-306)CAG>CAA	p.Q102Q	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Silent_p.Q102Q|FCRL1_uc001fri.2_Silent_p.Q102Q|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	102	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GCACATTTATCTGGGATCTCC	0.527													16	76					0	0	0	0	T	157773648	T	T	157773648	2	4	156	1	0	0	0	0	0	0	0	1	5826	912	32	2		2	FCRL1	1	157773648	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	2811598	157773648	91476973	13	28830											
ABL2	27	broad.mit.edu	37	chr1	179077340	179077340	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccagagctgccttctttcctCcttcctgtgtttctgatgtg	3	17	8	13	0	2	2	0	1	2	1	5	2	5	2	5	0	2	2	5	0	0	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:179077340C>T	uc001gmj.3	-	12	3349	c.3062G>A	c.(3061-3063)GGA>GAA	p.G1021E	ABL2_uc010pnf.1_Missense_Mutation_p.G918E|ABL2_uc010png.1_Missense_Mutation_p.G897E|ABL2_uc010pnh.1_Missense_Mutation_p.G1000E|ABL2_uc001gmg.3_Missense_Mutation_p.G903E|ABL2_uc001gmi.3_Missense_Mutation_p.G1006E|ABL2_uc001gmh.3_Missense_Mutation_p.G985E|ABL2_uc010pne.1_Missense_Mutation_p.G882E	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	1021	Pro-rich.|F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CTTCTTTCCTCCTTCCTGTGT	0.567			T	ETV6	AML								14	120					0	0	0	0	T	179077340	T	T	179077340	3	4	156	1	0	0	0	0	1	0	0	0	93	855	30	2	490	2	ABL2	1	179077340	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	21303692	179077340	70173281	14	28831											
MR1	3140	broad.mit.edu	37	chr1	181021478	181021478	+	Frame_Shift_Del	DEL	A	-	-																															aaatttacatgacatggatgAaaaacggggaagaaattgtc																										TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:181021478delA	uc001goq.1	+	4	717	c.712delA	c.(712-714)AAAfs	p.K238fs	MR1_uc001gor.1_Frame_Shift_Del_p.K193fs|MR1_uc001gos.1_Intron|MR1_uc010pns.1_Intron	NM_001531	NP_001522	Q95460	HMR1_HUMAN	major histocompatibility complex, class	238	Extracellular (Potential).|Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			skin(1)	1						GACATGGATGAAAAACGGGGA	0.443													---	---	---								-	181021478	-	-	181021478	7	5	156	1	0	1	0	1	0	0	0	0	9805	247	9	0	726	0	MR1	1	181021478	Frame_Shift_Del	DEL	A	TCGA-CR-7390-01A-11D-2012-08	1944138	181021478	68229143	15	28832											
HMCN1	83872	broad.mit.edu	37	chr1	185902690	185902690	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atttcacacagagccccctcCggtcatccaagtgcctaaca	11	8	6	16	1	2	1	2	0	0	1	4	1	4	1	5	1	3	0	5	1	2	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:185902690C>T	uc001grq.1	+	11	1791	c.1562C>T	c.(1561-1563)CCG>CTG	p.P521L		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	521	Ig-like C2-type 2.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAGCCCCCTCCGGTCATCCAA	0.413													13	29					0	0	0	0	T	185902690	T	T	185902690	3	4	156	1	0	0	0	0	1	0	0	0	7259	652	23	1	1604	1	HMCN1	1	185902690	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	4881212	185902690	63347931	16	28833											
TMEM183A	92703	broad.mit.edu	37	chr1	202984173	202984173	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttttggaccaggttgtaccGaaggtgcgaccacagagagc	10	8	13	10	2	0	1	0	0	0	1	0	5	0	2	3	3	3	2	3	3	2	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:202984173G>A	uc001gyu.1	+	4	582	c.524G>A	c.(523-525)CGA>CAA	p.R175Q	TMEM183A_uc009xai.1_Missense_Mutation_p.R175Q|TMEM183A_uc001gyv.1_RNA|TMEM183A_uc001gyw.1_Missense_Mutation_p.R174Q|TMEM183A_uc001gyx.1_Missense_Mutation_p.R174Q	NM_001079809	NP_001073277	Q8IXX5	T183A_HUMAN	transmembrane protein 183B	175						integral to membrane					0			BRCA - Breast invasive adenocarcinoma(75;0.18)			AGGTTGTACCGAAGGTGCGAC	0.463													7	43					0	0	0	0	A	202984173	A	A	202984173	3	1	156	1	0	0	0	0	1	0	0	0	16168	1058	37	1	538	1	TMEM183A	1	202984173	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	17081483	202984173	46266448	17	28834											
USH2A	7399	broad.mit.edu	37	chr1	216497666	216497666	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatttccgttggttgtggaCtaaagaactgaatgataata	13	15	9	4	1	0	3	0	2	0	1	1	4	1	4	1	2	1	2	1	2	7	7			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:216497666C>G	uc001hku.1	-	7	1559	c.1172G>C	c.(1171-1173)AGT>ACT	p.S391T	USH2A_uc001hkv.2_Missense_Mutation_p.S391T	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	391	Laminin N-terminal.|Extracellular (Potential).		S -> I (in USH2A; uncertain pathogenicity).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTTGTGGACTAAAGAACTG	0.318										HNSCC(13;0.011)			4	24					0	0	0	0	G	216497666	G	G	216497666	3	3	156	1	0	0	0	0	1	0	0	0	17104	565	20	4	14714	4	USH2A	1	216497666	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	13513493	216497666	32752955	18	28835											
OR2T4	127074	broad.mit.edu	37	chr1	248525032	248525032	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatcctgttgggactcttCagacaatccaaacatccagc	11	11	6	13	0	3	1	2	0	1	1	6	2	6	2	3	1	2	1	3	1	2	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr1:248525032C>G	uc001ieh.1	+	1	150	c.150C>G	c.(148-150)TTC>TTG	p.F50L		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	50	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGGACTCTTCAGACAATCCA	0.468													15	125					0	0	0	0	G	248525032	G	G	248525032	3	3	156	1	0	0	0	0	1	0	0	0	11081	825	29	2	152	2	OR2T4	1	248525032	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	32027366	248525032	725589	19	28836											
ITSN2	50618	broad.mit.edu	37	chr2	24432884	24432884	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggccccaggcagttggtgaGagagttgaaaataagttgct	11	9	15	6	0	0	3	0	2	0	1	0	4	0	3	2	3	1	5	2	3	3	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr2:24432884G>C	uc002rfe.2	-	35	4534	c.4276C>G	c.(4276-4278)CTC>GTC	p.L1426V	ITSN2_uc002rff.2_Missense_Mutation_p.L1399V	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1426					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGTTGGTGAGAGAGTTGAAA	0.478													32	106					0	0	0	0	C	24432884	C	C	24432884	3	2	156	1	0	0	0	0	1	0	0	0	7966	942	33	2	841	2	ITSN2	2	24432884	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08		24432884	218766489	20	28837											
NCOA1	8648	broad.mit.edu	37	chr2	24929454	24929454	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagggagcacagtgggctttCtcctcaagatgacactaatt	11	11	10	9	0	2	2	1	1	1	1	3	3	2	3	1	2	1	2	1	2	3	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr2:24929454C>G	uc002rfk.2	+	11	1373	c.1115C>G	c.(1114-1116)TCT>TGT	p.S372C	NCOA1_uc010eye.2_Missense_Mutation_p.S372C|NCOA1_uc002rfi.2_Missense_Mutation_p.S221C|NCOA1_uc002rfj.2_Missense_Mutation_p.S372C|NCOA1_uc002rfl.2_Missense_Mutation_p.S372C	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	372	Interaction with STAT3.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTGGGCTTTCTCCTCAAGAT	0.383			T	PAX3	alveolar rhadomyosarcoma								23	36					0	0	0	0	G	24929454	G	G	24929454	3	3	156	1	0	0	0	0	1	0	0	0	10282	913	32	2	1149	2	NCOA1	2	24929454	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	496570	24929454	218269919	21	28838											
ALK	238	broad.mit.edu	37	chr2	29606696	29606696	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgaaatgggttgtctggaCgcccgattcttccctggagc	6	11	12	12	3	2	0	0	0	2	0	4	4	3	2	2	3	1	1	2	3	1	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr2:29606696C>T	uc002rmy.2	-	5	2091	c.1184G>A	c.(1183-1185)CGT>CAT	p.R395H		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	395	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GTTGTCTGGACGCCCGATTCT	0.493			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				10	103					0	0	0	0	T	29606696	T	T	29606696	3	4	156	1	0	0	0	0	1	0	0	0	525	536	19	1	3778	1	ALK	2	29606696	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	4677242	29606696	213592677	22	28839											
WBP1	23559	broad.mit.edu	37	chr2	74687380	74687380	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccttcaagcccccagcctacGaggatgtggttcaccgccca	8	7	9	17	2	2	0	2	0	0	0	2	2	2	1	6	2	3	1	6	2	2	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr2:74687380G>C	uc002slj.1	+	4	535	c.382G>C	c.(382-384)GAG>CAG	p.E128Q	WBP1_uc002slh.1_RNA|INO80B_uc002sli.1_RNA|WBP1_uc002slk.1_Missense_Mutation_p.E125Q|WBP1_uc002sll.1_RNA	NM_012477	NP_036609	Q96G27	WBP1_HUMAN	WW domain binding protein 1	128							WW domain binding				0						CCCAGCCTACGAGGATGTGGT	0.552													46	146					0	0	0	0	C	74687380	C	C	74687380	3	2	156	1	0	0	0	0	1	0	0	0	17325	1059	37	3	396	3	WBP1	2	74687380	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	45080684	74687380	168511993	23	28840											
LMAN2L	81562	broad.mit.edu	37	chr2	97377727	97377727	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgatcatagctgagggagccGttgttcaccatggctgagat	9	11	13	8	1	2	3	2	3	0	1	2	5	2	4	2	2	2	4	2	2	1	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr2:97377727G>A	uc002swu.2	-	5	579	c.543C>T	c.(541-543)AAC>AAT	p.N181N	LMAN2L_uc002swv.2_Silent_p.N192N|LMAN2L_uc010yut.1_Silent_p.N47N|LMAN2L_uc010yuu.1_Silent_p.N45N|LMAN2L_uc010yuv.1_Silent_p.N34N|LMAN2L_uc010yuw.1_Silent_p.N36N|LMAN2L_uc002sww.2_Silent_p.N34N|LMAN2L_uc010yux.1_Silent_p.N36N	NM_030805	NP_110432	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like isoform 2	181	L-type lectin-like.|Lumenal (Potential).				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding				0						TGAGGGAGCCGTTGTTCACCA	0.552													16	121					0	0	0	0	A	97377727	A	A	97377727	2	1	156	1	0	0	0	0	0	0	0	1	8881	1136	40	1		1	LMAN2L	2	97377727	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	22690347	97377727	145821646	24	28841											
EN1	2019	broad.mit.edu	37	chr2	119600538	119600538	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcgctctcgtctttgtcctgGaccgtggtggtggagtggtt	2	15	15	9	3	2	0	0	0	2	0	5	2	3	2	2	5	0	2	2	5	0	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr2:119600538G>T	uc002tlm.2	-	2	2171	c.1155C>A	c.(1153-1155)GTC>GTA	p.V385V		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	385					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						CTTTGTCCTGGACCGTGGTGG	0.498													8	41					1.12685e-05	4.40329e-05	1	0	T	119600538	T	T	119600538	2	4	156	1	0	0	0	0	0	0	0	1	5133	1161	41	2		2	EN1	2	119600538	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	22222811	119600538	123598835	25	28842											
LY75	4065	broad.mit.edu	37	chr2	160673380	160673380	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttacaatatcttccagaaaGagctggccattttggttgtg	10	15	9	7	0	1	2	0	0	1	2	2	2	2	2	2	2	2	2	2	2	4	7			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr2:160673380G>C	uc002ubc.3	-	30	4386	c.4317C>G	c.(4315-4317)CTC>CTG	p.L1439L	LY75_uc002ubb.3_Silent_p.L1439L|LY75_uc010fos.2_Silent_p.L1439L	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1439	Extracellular (Potential).|C-type lectin 9.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		CTTCCAGAAAGAGCTGGCCAT	0.393													15	84					0	0	0	0	C	160673380	C	C	160673380	2	2	156	1	0	0	0	0	0	0	0	1	9150	929	33	2		2	LY75	2	160673380	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	41072842	160673380	82525993	26	28843											
TTN	7273	broad.mit.edu	37	chr2	179539081	179539081	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaacttcctctatgctaggTggttcttctgggatttcttc	5	18	8	10	0	5	0	1	0	4	0	7	1	6	1	1	3	2	2	1	3	3	7			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr2:179539081T>G	uc010zfg.1	-	146	30989	c.30765A>C	c.(30763-30765)CCA>CCC	p.P10255P	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.P6916P|TTN_uc010fre.1_Silent_p.P763P|TTN_uc010zfk.1_5'Flank|TTN_uc002una.1_RNA|TTN_uc010frf.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11182							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTATGCTAGGTGGTTCTTCTG	0.333													4	6					0	0	0	0	G	179539081	G	G	179539081	2	3	156	1	0	0	0	0	0	0	0	1	16803	1683	59	5		5	TTN	2	179539081	Silent	SNP	T	TCGA-CR-7390-01A-11D-2012-08	18865701	179539081	63660292	27	28844											
EPHA4	2043	broad.mit.edu	37	chr2	222298932	222298932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccacataacgattccatagCtccatacatcacttgctgat	12	11	4	14	1	1	1	1	1	0	0	3	2	3	1	3	0	4	2	3	0	3	5			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr2:222298932C>T	uc002vmq.2	-	14	2468	c.2426G>A	c.(2425-2427)AGC>AAC	p.S809N	EPHA4_uc002vmr.2_Missense_Mutation_p.S809N|EPHA4_uc010zlm.1_Missense_Mutation_p.S750N|EPHA4_uc010zln.1_Missense_Mutation_p.S809N	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	809	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GATTCCATAGCTCCATACATC	0.433													34	57					0	0	0	0	T	222298932	T	T	222298932	3	4	156	1	0	0	0	0	1	0	0	0	5193	797	28	4	550	4	EPHA4	2	222298932	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	42759851	222298932	20900441	28	28845											
IL17RE	132014	broad.mit.edu	37	chr3	9944734	9944734	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actggaacacccgctgtcctCtggcctcccacacggtaagg	8	7	10	16	2	1	0	0	0	1	0	3	1	3	1	4	4	1	2	4	4	2	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr3:9944734C>G	uc003btu.2	+	2	235	c.118C>G	c.(118-120)CTG>GTG	p.L40V	CIDEC_uc003bto.2_Intron|IL17RE_uc003btv.2_Missense_Mutation_p.L40V|IL17RE_uc011atn.1_RNA|IL17RE_uc003btw.2_Missense_Mutation_p.L40V|IL17RE_uc003btx.2_5'UTR|IL17RE_uc010hcq.2_Missense_Mutation_p.L40V|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	40	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		CCGCTGTCCTCTGGCCTCCCA	0.637													14	45					0	0	0	0	G	9944734	G	G	9944734	3	3	156	1	0	0	0	0	1	0	0	0	7682	912	32	2	120	2	IL17RE	3	9944734	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08		9944734	188077696	29	28846											
WDR52	55779	broad.mit.edu	37	chr3	113098399	113098399	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttcaatttctattaatctCttttaaaataaacattaagt	15	20	1	5	0	3	0	1	0	2	0	4	0	3	0	0	0	1	0	0	0	8	9			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr3:113098399C>G	uc003eae.1	-	17	2099	c.2053_splice	c.e17-1	p.R685_splice		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2											central_nervous_system(1)	1						CTATTAATCTCTTTTAAAATA	0.343													7	61					0	0	0	0	G	113098399	G	G	113098399	5	3	156	1	0	0	0	0	0	0	1	0	17372	927	32	2	3603	2	WDR52	3	113098399	Splice_Site	SNP	C	TCGA-CR-7390-01A-11D-2012-08	103153665	113098399	84924031	30	28847											
ARHGAP31	57514	broad.mit.edu	37	chr3	119133482	119133482	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacattgcccagcatggcctGgagatggtggagccctggga	8	7	16	10	0	0	1	0	0	0	1	0	5	0	3	3	5	3	1	3	5	0	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr3:119133482G>A	uc003ecj.3	+	12	3238	c.2706G>A	c.(2704-2706)CTG>CTA	p.L902L		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	902					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						AGCATGGCCTGGAGATGGTGG	0.572													36	141					0	0	0	0	A	119133482	A	A	119133482	2	1	156	1	0	0	0	0	0	0	0	1	880	1335	47	4		4	ARHGAP31	3	119133482	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	6035083	119133482	78888948	31	28848											
ALDH1L1	10840	broad.mit.edu	37	chr3	125828902	125828902	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgattctgcggcccgtggtcGgtgtccctgtccagcgggtt	2	12	15	12	4	1	1	0	1	1	0	4	1	3	1	3	4	2	1	3	4	0	2	rs141918591		TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr3:125828902G>A	uc003eim.1	-	20	2422	c.2232C>T	c.(2230-2232)ACC>ACT	p.T744T	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Silent_p.T643T|ALDH1L1_uc003ein.1_Silent_p.T279T	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	744	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GCCCGTGGTCGGTGTCCCTGT	0.597													10	86					0	0	0	0	A	125828902	A	A	125828902	2	1	156	1	0	0	0	0	0	0	0	1	494	1103	39	1		1	ALDH1L1	3	125828902	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	6695420	125828902	72193528	32	28849											
ALDH1L1	10840	broad.mit.edu	37	chr3	125833454	125833454	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagatgatgaggggtgacttCccgcccagttccagggacac	10	7	13	11	1	0	4	0	3	0	1	2	5	2	5	3	3	0	1	3	3	1	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr3:125833454C>T	uc003eim.1	-	18	2218	c.2028G>A	c.(2026-2028)GGG>GGA	p.G676G	ALDH1L1_uc010hse.1_Intron|ALDH1L1_uc011bki.1_Silent_p.G575G|ALDH1L1_uc003ein.1_Silent_p.G211G	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	676	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GGGGTGACTTCCCGCCCAGTT	0.617													6	194					0	0	0	0	T	125833454	T	T	125833454	2	4	156	1	0	0	0	0	0	0	0	1	494	842	30	2		2	ALDH1L1	3	125833454	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	4552	125833454	72188976	33	28850											
ZIC4	84107	broad.mit.edu	37	chr3	147114162	147114162	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtccattcaaaggacggctGggggaggcctggggaggctc	8	6	18	9	1	1	0	1	0	0	0	3	3	2	3	2	8	0	2	2	8	1	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr3:147114162G>C	uc003ewd.1	-	3	438	c.165C>G	c.(163-165)CCC>CCG	p.P55P	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Silent_p.P105P	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	55						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						AAGGACGGCTGGGGGAGGCCT	0.721													7	33					0	0	0	0	C	147114162	C	C	147114162	2	2	156	1	0	0	0	0	0	0	0	1	17748	1335	47	4		4	ZIC4	3	147114162	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	21280708	147114162	50908268	34	28851											
BCHE	590	broad.mit.edu	37	chr3	165547586	165547586	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcacccaaggcctcacggtaGttttcaggtctctgatcatc	8	12	8	13	1	5	1	4	1	1	0	7	1	5	1	2	3	0	2	2	3	2	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr3:165547586G>A	uc003fem.3	-	2	1396	c.1236C>T	c.(1234-1236)AAC>AAT	p.N412N	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	412					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	CCTCACGGTAGTTTTCAGGTC	0.408													70	35					0	0	0	0	A	165547586	A	A	165547586	2	1	156	1	0	0	0	0	0	0	0	1	1360	1020	36	4		4	BCHE	3	165547586	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	18433424	165547586	32474844	35	28852											
LRRC31	79782	broad.mit.edu	37	chr3	169569457	169569457	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagttgttgataactaatGacttcaatgctggtaaaaat	15	13	7	6	0	1	2	1	2	0	0	1	2	1	2	0	1	2	4	0	1	6	6			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr3:169569457G>A	uc003fgc.1	-	7	1186	c.1109C>T	c.(1108-1110)TCA>TTA	p.S370L	LRRC31_uc010hwp.1_Missense_Mutation_p.S314L	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	370	LRR 6.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			GATAACTAATGACTTCAATGC	0.413													9	78					0	0	0	0	A	169569457	A	A	169569457	3	1	156	1	0	0	0	0	1	0	0	0	9036	1294	45	2	561	2	LRRC31	3	169569457	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	4021871	169569457	28452973	36	28853											
ATP11B	23200	broad.mit.edu	37	chr3	182575744	182575745	+	Frame_Shift_Ins	INS	-	T	T																															gcactatcttgaagtatacaINStggcaagctgaagaaaaatg																										TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr3:182575744_182575745insT	uc003flb.2	+	11	1187_1188	c.930_931insT	c.(928-933)ACATGGfs	p.T310fs		NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	310_311	Helical; (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TGAAGTATACATGGCAAGCTGA	0.312													---	---	---								T	182575745	T	T	182575744	7	5	156	1	0	1	1	0	0	0	0	0	1122	204	8	0	972	0	ATP11B	3	182575744	Frame_Shift_Ins	INS	-	TCGA-CR-7390-01A-11D-2012-08	13006287	182575744	15446686	37	28854											
PI4K2B	55300	broad.mit.edu	37	chr4	25258233	25258233	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaaaatcaagaggcaaaaaGtatgctttagaaaaagtgcc	19	7	9	6	0	1	2	1	0	0	2	1	2	1	2	1	1	2	4	1	1	9	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr4:25258233G>A	uc003grk.2	+	4	826	c.693G>A	c.(691-693)AAG>AAA	p.K231K	PI4K2B_uc011bxs.1_Silent_p.K135K	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta	231	PI3K/PI4K.					cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding	p.K231K(1)		ovary(2)|skin(2)	4		Breast(46;0.173)				GAGGCAAAAAGTATGCTTTAG	0.373													5	35					0	0	0	0	A	25258233	A	A	25258233	2	1	156	1	0	0	0	0	0	0	0	1	11927	1020	36	4		4	PI4K2B	4	25258233	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08		25258233	165896043	38	28855											
MOBKL1A	92597	broad.mit.edu	37	chr4	71840892	71840892	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgagtatcattgggcagatGgaacgaacataaagaaacct	17	8	10	6	1	1	3	1	1	0	2	1	5	1	4	1	2	3	2	1	2	6	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr4:71840892G>T	uc003hfw.2	+	4	488	c.298G>T	c.(298-300)GGA>TGA	p.G100*	MOBKL1A_uc003hfv.1_Nonsense_Mutation_p.G100*|MOBKL1A_uc011cba.1_Nonsense_Mutation_p.G105*	NM_173468	NP_775739	Q7L9L4	MOL1A_HUMAN	MOB1, Mps One Binder kinase activator-like 1A	100					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			TTGGGCAGATGGAACGAACAT	0.348													6	43					5.9392e-07	2.38563e-06	1	0	T	71840892	T	T	71840892	4	4	156	1	0	0	0	0	0	1	0	0	9735	1349	47	4	312	4	MOBKL1A	4	71840892	Nonsense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	46582659	71840892	119313384	39	28856											
FAM175A	84142	broad.mit.edu	37	chr4	84383771	84383771	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcttgtgtatctaacaaccGagatctcttgaattgccatc	10	14	7	10	1	3	2	0	1	3	1	5	3	3	2	2	0	3	1	2	0	4	5			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr4:84383771G>T	uc003hou.2	-	9	1146	c.1081C>A	c.(1081-1083)CGG>AGG	p.R361R	MRPS18C_uc011ccu.1_Intron|FAM175A_uc003hot.2_Silent_p.R189R|FAM175A_uc003hov.2_Silent_p.R252R	NM_139076	NP_620775	Q6UWZ7	F175A_HUMAN	coiled-coil domain containing 98	361					chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1						TCTAACAACCGAGATCTCTTG	0.393													34	120					1.26612e-14	5.41868e-14	1	0	T	84383771	T	T	84383771	2	4	156	1	0	0	0	0	0	0	0	1	5525	1057	37	3		3	FAM175A	4	84383771	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	12542879	84383771	106770505	40	28857											
ARSJ	79642	broad.mit.edu	37	chr4	114824711	114824711	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaagtgccattttccgacCatatgcgttgaatatccaac	11	11	6	13	2	0	1	0	1	0	0	2	2	2	1	5	0	3	1	5	0	5	5			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr4:114824711C>T	uc003ibq.1	-	2	1407	c.519G>A	c.(517-519)ATG>ATA	p.M173I	ARSJ_uc010imu.1_Missense_Mutation_p.M173I|ARSJ_uc010imv.1_Missense_Mutation_p.M1I	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	173						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		ATTTTCCGACCATATGCGTTG	0.433													16	83					0	0	0	0	T	114824711	T	T	114824711	3	4	156	1	0	0	0	0	1	0	0	0	997	594	21	4	1284	4	ARSJ	4	114824711	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	30440940	114824711	76329565	41	28858											
FAT1	2195	broad.mit.edu	37	chr4	187517874	187517874	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgggatagcagatccttCgaaggaatttcggtccagat	10	11	11	9	2	1	2	0	0	1	2	5	5	3	4	2	3	1	1	2	3	3	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr4:187517874C>A	uc003izf.2	-	25	13008	c.12820G>T	c.(12820-12822)GAA>TAA	p.E4274*	FAT1_uc010isn.2_5'Flank|FAT1_uc003ize.2_Nonsense_Mutation_p.E165*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4274	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCAGATCCTTCGAAGGAATTT	0.532										HNSCC(5;0.00058)			19	14					7.45023e-12	3.15101e-11	1	0	A	187517874	A	A	187517874	4	1	156	1	0	0	0	0	0	1	0	0	5721	893	31	3	958	3	FAT1	4	187517874	Nonsense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	72693163	187517874	3636402	42	28859											
SLC6A18	348932	broad.mit.edu	37	chr5	1232407	1232407	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttccacgtcgagctcgccatCggccagcggctgcggaaggg	6	6	15	14	6	0	0	0	0	0	0	4	2	1	1	3	4	3	2	3	4	1	1	rs141321317	byFrequency	TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr5:1232407C>T	uc003jby.1	+	2	357	c.234C>T	c.(232-234)ATC>ATT	p.I78I		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	78	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AGCTCGCCATCGGCCAGCGGC	0.662													5	44					0	0	0	0	T	1232407	T	T	1232407	2	4	156	1	0	0	0	0	0	0	0	1	14745	874	31	1		1	SLC6A18	5	1232407	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08		1232407	179682853	43	28860											
RXFP3	51289	broad.mit.edu	37	chr5	33937333	33937333	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatcgtgtccatggtgacgtCcatgaacatgtacgccagcg	9	9	12	11	4	0	2	0	2	0	0	3	3	2	2	3	1	3	1	3	1	2	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr5:33937333C>T	uc003jic.1	+	1	845	c.488C>T	c.(487-489)TCC>TTC	p.S163F		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	163	Helical; Name=3; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						ATGGTGACGTCCATGAACATG	0.582													18	66					0	0	0	0	T	33937333	T	T	33937333	3	4	156	1	0	0	0	0	1	0	0	0	13826	855	30	2	490	2	RXFP3	5	33937333	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	32704926	33937333	146977927	44	28861											
ITGA2	3673	broad.mit.edu	37	chr5	52376453	52376453	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggggtgcaaacagacaaggTaaagattaaaaaattgccta	18	8	10	5	0	0	2	0	0	0	2	0	2	0	2	1	3	3	2	1	3	8	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr5:52376453T>C	uc003joy.2	+	25	3182	c.3039_splice	c.e25+2	p.K1013_splice	ITGA2_uc011cqa.1_Splice_Site|ITGA2_uc011cqb.1_Splice_Site|ITGA2_uc011cqc.1_Splice_Site_p.K937_splice|ITGA2_uc011cqd.1_Splice_Site|ITGA2_uc011cqe.1_Splice_Site	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor						axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				ACAGACAAGGTAAAGATTAAA	0.383													19	47					0	0	0	0	C	52376453	C	C	52376453	5	2	156	1	0	0	0	0	0	0	1	0	7914	1652	57	5	3139	5	ITGA2	5	52376453	Splice_Site	SNP	T	TCGA-CR-7390-01A-11D-2012-08	18439120	52376453	128538807	45	28862											
NLN	57486	broad.mit.edu	37	chr5	65054536	65054536	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaaattaaaacaagaactGaggagctcattgtgcagacc	17	7	9	8	0	1	3	1	1	0	2	1	4	1	4	1	1	5	3	1	1	5	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr5:65054536G>C	uc003juf.2	+	2	300	c.184G>C	c.(184-186)GAG>CAG	p.E62Q	NLN_uc003jue.2_Missense_Mutation_p.E62Q	NM_020726	NP_065777	Q9BYT8	NEUL_HUMAN	neurolysin precursor	62					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		AACAAGAACTGAGGAGCTCAT	0.448													15	39					0	0	0	0	C	65054536	C	C	65054536	3	2	156	1	0	0	0	0	1	0	0	0	10521	1291	45	2	190	2	NLN	5	65054536	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	12678083	65054536	115860724	46	28863											
SPZ1	84654	broad.mit.edu	37	chr5	79616524	79616524	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaagaaaatatcagaggaCttgacaaaatcaatgaaatg	22	7	7	5	0	2	4	2	2	0	2	2	5	2	5	0	1	0	0	0	1	8	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr5:79616524C>G	uc003kgn.2	+	1	735	c.490C>G	c.(490-492)CTT>GTT	p.L164V	uc011ctk.1_Intron	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		TATCAGAGGACTTGACAAAAT	0.368													7	33					0	0	0	0	G	79616524	G	G	79616524	3	3	156	1	0	0	0	0	1	0	0	0	15193	565	20	4	492	4	SPZ1	5	79616524	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	14561988	79616524	101298736	47	28864											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139865277	139865277	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtcagttcccaccacagAtgtgtctcagctccctccac	7	11	6	17	0	3	1	2	0	2	1	7	1	6	1	4	0	1	2	4	0	0	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr5:139865277A>T	uc003lfs.1	+	13	2226	c.2102A>T	c.(2101-2103)GAT>GTT	p.D701V	ANKHD1_uc003lfq.1_Missense_Mutation_p.D720V|ANKHD1_uc003lfr.2_Missense_Mutation_p.D701V|ANKHD1_uc003lft.1_Missense_Mutation_p.D181V|ANKHD1_uc003lfu.1_Missense_Mutation_p.D181V|ANKHD1_uc003lfv.1_Missense_Mutation_p.D31V	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	701						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCACCACAGATGTGTCTCAG	0.378													9	34					0	0	0	0	T	139865277	T	T	139865277	3	4	156	1	0	0	0	0	1	0	0	0	629	333	12	5	2152	5	ANKHD1-EIF4EBP3	5	139865277	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	60248753	139865277	41049983	48	28865											
PCDHGA10	56106	broad.mit.edu	37	chr5	140793166	140793166	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaattccaagcagaaaatCtagacgtaaaaattaatgaa	22	8	5	6	1	1	3	0	1	1	2	2	3	2	3	1	0	1	2	1	0	11	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr5:140793166C>G	uc003lkl.1	+	1	424	c.424C>G	c.(424-426)CTA>GTA	p.L142V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.L142V	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	142	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAGAAAATCTAGACGTAAA	0.413													10	26					0	0	0	0	G	140793166	G	G	140793166	3	3	156	1	0	0	0	0	1	0	0	0	11605	912	32	2	426	2	PCDHGA10	5	140793166	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	927889	140793166	40122094	49	28866											
CYFIP2	26999	broad.mit.edu	37	chr5	156816398	156816398	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagcgccatgcagttcgtgTactgcatccctgtgggaacc	7	9	13	12	2	0	0	0	0	0	0	2	2	1	2	3	2	5	4	3	2	2	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr5:156816398T>A	uc003lwq.2	+	31	3547	c.3409T>A	c.(3409-3411)TAC>AAC	p.Y1137N	CYFIP2_uc011ddn.1_Missense_Mutation_p.Y1111N|CYFIP2_uc011ddo.1_Missense_Mutation_p.Y941N|CYFIP2_uc003lwr.2_Missense_Mutation_p.Y1137N|CYFIP2_uc003lws.2_Missense_Mutation_p.Y1137N|CYFIP2_uc003lwt.2_Missense_Mutation_p.Y1040N|CYFIP2_uc011ddp.1_Missense_Mutation_p.Y871N|CYFIP2_uc003lwv.2_Missense_Mutation_p.Y92N	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1162					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCAGTTCGTGTACTGCATCCC	0.622													7	15					0	0	0	0	A	156816398	A	A	156816398	3	1	156	1	0	0	0	0	1	0	0	0	4155	1638	57	5	3519	5	CYFIP2	5	156816398	Missense_Mutation	SNP	T	TCGA-CR-7390-01A-11D-2012-08	16023232	156816398	24098862	50	28867											
KIAA0319	9856	broad.mit.edu	37	chr6	24570136	24570136	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgagacagactacctgacGtgctcccagtggtagaagac	11	6	13	11	2	0	5	0	1	0	4	1	6	1	5	2	2	2	2	2	2	3	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr6:24570136G>A	uc011djo.1	-	12	2223	c.1986C>T	c.(1984-1986)CAC>CAT	p.H662H	KIAA0319_uc011djp.1_Silent_p.H617H|KIAA0319_uc003neh.1_Silent_p.H662H|KIAA0319_uc011djq.1_Silent_p.H653H|KIAA0319_uc011djr.1_Silent_p.H662H|KIAA0319_uc010jpt.1_Silent_p.H73H	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	662	PKD 4.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						ACTACCTGACGTGCTCCCAGT	0.527													10	21					0	0	0	0	A	24570136	A	A	24570136	2	1	156	1	0	0	0	0	0	0	0	1	8207	1136	40	1		1	KIAA0319	6	24570136	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08		24570136	146544931	51	28868											
MDC1	9656	broad.mit.edu	37	chr6	30668370	30668370	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtagtggaatggagcaatGagggaagtcctgagggcatg	11	7	17	6	1	0	2	0	2	0	0	1	5	1	5	2	4	1	3	2	4	4	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr6:30668370G>T	uc003nrg.3	-	15	6582	c.6142C>A	c.(6142-6144)CAT>AAT	p.H2048N	MDC1_uc003nrf.3_Missense_Mutation_p.H679N	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	2048	Required for nuclear localization (NLS2).|BRCT 2.			H -> R (in Ref. 2).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						ATGGAGCAATGAGGGAAGTCC	0.537								Other_conserved_DNA_damage_response_genes					6	91					2.0095e-06	7.98248e-06	1	0	T	30668370	T	T	30668370	3	4	156	1	0	0	0	0	1	0	0	0	9456	1290	45	2	131	2	MDC1	6	30668370	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	6098234	30668370	140446697	52	28869											
HSPA1L	3305	broad.mit.edu	37	chr6	31778361	31778361	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgctggagggattccagtCaggtcaaaccgccccagcag	9	6	14	12	1	2	0	2	0	0	0	3	2	3	2	4	4	3	2	4	4	1	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr6:31778361C>G	uc003nxh.2	-	2	1572	c.1389G>C	c.(1387-1389)CTG>CTC	p.L463L	HSPA1L_uc010jte.2_Silent_p.L463L	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	463					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						GGATTCCAGTCAGGTCAAACC	0.552													34	100					0	0	0	0	G	31778361	G	G	31778361	2	3	156	1	0	0	0	0	0	0	0	1	7449	813	29	2		2	HSPA1L	6	31778361	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	1109991	31778361	139336706	53	28870											
TEAD3	7005	broad.mit.edu	37	chr6	35443391	35443391	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggagcacaccttggtggaGacgctgatggtcatgctatc	10	9	13	9	1	1	2	1	1	0	1	2	4	1	3	1	4	2	3	1	4	2	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr6:35443391G>A	uc003oku.3	-	11	1229	c.993C>T	c.(991-993)GTC>GTT	p.V331V	TEAD3_uc003okt.2_Silent_p.V220V|TEAD3_uc010jvx.2_Silent_p.V271V	NM_003214	NP_003205	Q99594	TEAD3_HUMAN	TEA domain family member 3	331	Transcriptional activation (Potential).				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCTTGGTGGAGACGCTGATGG	0.617													13	42					0	0	0	0	A	35443391	A	A	35443391	2	1	156	1	0	0	0	0	0	0	0	1	15806	929	33	2		2	TEAD3	6	35443391	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	3665030	35443391	135671676	54	28871											
DST	667	broad.mit.edu	37	chr6	56426298	56426313	+	Frame_Shift_Del	DEL	TTCATAACCATGACTT	-	-																															ttgagtaagaggccaagatcTtcataaccatgacttatgtc																										TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr6:56426298_56426313delTTCATAACCATGACTT	uc003pdf.2	-	51	7774_7789	c.7746_7761delAAGTCATGGTTATGAA	c.(7744-7761)ATAAGTCATGGTTATGAAfs	p.I2582fs	DST_uc003pcz.3_Frame_Shift_Del_p.I2404fs|DST_uc011dxj.1_Frame_Shift_Del_p.I2433fs|DST_uc011dxk.1_Frame_Shift_Del_p.I2444fs|DST_uc003pcy.3_Frame_Shift_Del_p.I2078fs	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4490_4495					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GGCCAAGATCTTCATAACCATGACTTATGTCAGTCA	0.384													---	---	---								-	56426313	-	-	56426298	7	5	156	1	0	1	0	1	0	0	0	0	4805	1606	56	0	9454	0	DST	6	56426298	Frame_Shift_Del	DEL	TTCATAACCATGACTT	TCGA-CR-7390-01A-11D-2012-08	20982907	56426298	114688769	55	28872											
RIPPLY2	134701	broad.mit.edu	37	chr6	84567050	84567050	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaattcaagccacaatttCattttatgaagattctgata	14	15	4	8	0	3	3	2	2	1	1	4	3	4	3	2	0	1	0	2	0	6	6			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr6:84567050C>G	uc003pke.2	+	4	480	c.329C>G	c.(328-330)TCA>TGA	p.S110*	CYB5R4_uc003pkf.2_5'Flank	NM_001009994	NP_001009994	Q5TAB7	RIPP2_HUMAN	ripply2 protein	110	Ripply homology domain.				somite rostral/caudal axis specification	nucleus					0						GCCACAATTTCATTTTATGAA	0.323													15	53					0	0	0	0	G	84567050	G	G	84567050	4	3	156	1	0	0	0	0	0	1	0	0	13450	838	29	2	343	2	RIPPLY2	6	84567050	Nonsense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	28140752	84567050	86548017	56	28873											
EPHA7	2045	broad.mit.edu	37	chr6	94066437	94066437	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gataaacacaaaacatacctGcttgaccagtggtgatactg	15	9	8	9	0	0	2	0	2	0	0	0	3	0	2	2	1	5	1	2	1	6	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr6:94066437G>T	uc003poe.2	-	5	1563	c.1322C>A	c.(1321-1323)GCA>GAA	p.A441E	EPHA7_uc003pof.2_Missense_Mutation_p.A441E|EPHA7_uc011eac.1_Missense_Mutation_p.A441E	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	441	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		AAACATACCTGCTTGACCAGT	0.398													9	39					7.48243e-07	2.98881e-06	1	0	T	94066437	T	T	94066437	3	4	156	1	0	0	0	0	1	0	0	0	5196	1319	46	4	1726	4	EPHA7	6	94066437	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	9499387	94066437	77048630	57	28874											
SNX3	8724	broad.mit.edu	37	chr6	108533400	108533400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagcttttatctattatttCatcttgtaaaaacatgtgaa	14	18	4	5	0	3	1	1	1	2	0	3	1	3	1	0	0	2	2	0	0	8	8			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr6:108533400C>T	uc003psh.2	-	4	781	c.442G>A	c.(442-444)GAA>AAA	p.E148K	SNX3_uc003psi.2_Missense_Mutation_p.E116K|SNX3_uc010kdi.2_RNA	NM_003795	NP_003786	O60493	SNX3_HUMAN	sorting nexin 3 isoform a	148	PX.				cell communication|endocytosis|protein transport	early endosome|endosome membrane	phosphatidylinositol-3-phosphate binding|protein phosphatase binding				0		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0136)|Epithelial(106;0.0564)|OV - Ovarian serous cystadenocarcinoma(136;0.0717)|all cancers(137;0.0743)		TCTATTATTTCATCTTGTAAA	0.338													4	23					0	0	0	0	T	108533400	T	T	108533400	3	4	156	1	0	0	0	0	1	0	0	0	14963	835	29	2	50	2	SNX3	6	108533400	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	14466963	108533400	62581667	58	28875											
ZBTB24	9841	broad.mit.edu	37	chr6	109796641	109796641	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttctttagctgagacacatCcatgaatttgcgatggcagt	10	14	9	8	1	1	2	0	2	1	1	2	4	2	2	1	1	2	2	1	1	2	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr6:109796641C>A	uc003ptl.1	-	5	1417	c.1249G>T	c.(1249-1251)GAT>TAT	p.D417Y	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.D361Y|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	417	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.D417Y(1)		ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		TGAGACACATCCATGAATTTG	0.458													16	73					3.41278e-10	1.41022e-09	1	0	A	109796641	A	A	109796641	3	1	156	1	0	0	0	0	1	0	0	0	17598	855	30	2	856	2	ZBTB24	6	109796641	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	1263241	109796641	61318426	59	28876											
RSPH10B2	728194	broad.mit.edu	37	chr7	6820509	6820509	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aacattcgtccaaatgcctgCcagataaaaggtaaatacaa	18	8	6	9	1	0	1	0	0	0	1	2	1	1	1	3	1	4	1	3	1	8	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:6820509C>A	uc003sqw.1	+	14	1870	c.1599C>A	c.(1597-1599)TGC>TGA	p.C533*	RSPH10B2_uc010ktk.1_Nonsense_Mutation_p.C533*|RSPH10B2_uc011jxc.1_Intron|RSPH10B2_uc010ktl.1_Intron	NM_173565	NP_775836	B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B	533										ovary(1)|pancreas(1)|skin(1)	3						CAAATGCCTGCCAGATAAAAG	0.303													5	140					4.68919e-08	1.90482e-07	1	0	A	6820509	A	A	6820509	4	1	156	1	0	0	0	0	0	1	0	0	13769	747	26	4	4334	4	RSPH10B2	7	6820509	Nonsense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08		6820509	152318154	60	28877											
NXPH1	30010	broad.mit.edu	37	chr7	8791329	8791329	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttccttttatagtacagattAtaaactggtacagaaagtgt	14	15	7	5	0	0	2	0	0	0	2	1	2	1	2	1	1	3	2	1	1	8	8			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:8791329A>G	uc003srv.2	+	3	1657	c.746A>G	c.(745-747)TAT>TGT	p.Y249C	NXPH1_uc011jxh.1_Missense_Mutation_p.Y132C	NM_152745	NP_689958	P58417	NXPH1_HUMAN	neurexophilin 1 precursor	249	V (Cys-rich).					extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		AGTACAGATTATAAACTGGTA	0.448													7	20					0	0	0	0	G	8791329	G	G	8791329	3	3	156	1	0	0	0	0	1	0	0	0	10844	449	16	5	752	5	NXPH1	7	8791329	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	1970820	8791329	150347334	61	28878											
ITGB8	3696	broad.mit.edu	37	chr7	20421484	20421484	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aactgtcatctgaaaaacaaCgtctatgtcaaatcgacaac	17	9	5	10	2	4	1	2	1	2	0	5	2	4	1	0	0	4	0	0	0	7	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:20421484C>T	uc003suu.2	+	6	1641	c.936C>T	c.(934-936)AAC>AAT	p.N312N	ITGB8_uc011jyh.1_Silent_p.N177N|ITGB8_uc003sut.2_Silent_p.N312N	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	312	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						TGAAAAACAACGTCTATGTCA	0.413													5	52					0	0	0	0	T	20421484	T	T	20421484	2	4	156	1	0	0	0	0	0	0	0	1	7940	535	19	1		1	ITGB8	7	20421484	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	11630155	20421484	138717179	62	28879											
SP4	6671	broad.mit.edu	37	chr7	21550740	21550740	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagaataaaaaaggtggtggGacagctcttgccattgttac	13	10	11	7	0	1	1	0	0	1	1	1	2	1	2	1	3	3	2	1	3	5	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:21550740G>A	uc003sva.2	+	6	2389	c.2208G>A	c.(2206-2208)GGG>GGA	p.G736G	SP4_uc003svb.2_Silent_p.G423G	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	736					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						AAGGTGGTGGGACAGCTCTTG	0.448													9	92					0	0	0	0	A	21550740	A	A	21550740	2	1	156	1	0	0	0	0	0	0	0	1	15030	1161	41	2		2	SP4	7	21550740	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	1129256	21550740	137587923	63	28880											
DNAH11	8701	broad.mit.edu	37	chr7	21639716	21639716	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgaaccgaatagcaacacaCctggaaattaaaaattatca	20	8	5	8	1	1	1	1	1	0	0	1	3	1	2	2	1	3	1	2	1	9	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:21639716C>T	uc003svc.2	+	15	3010	c.2979C>T	c.(2977-2979)CAC>CAT	p.H993H		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	993	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TAGCAACACACCTGGAAATTA	0.303									Kartagener_syndrome				5	61					0	0	0	0	T	21639716	T	T	21639716	2	4	156	1	0	0	0	0	0	0	0	1	4621	506	18	4		4	DNAH11	7	21639716	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	88976	21639716	137498947	64	28881											
BMPER	168667	broad.mit.edu	37	chr7	34125518	34125518	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacttcaagtttgatgtggAtgactttgctgaatcttgga	11	15	10	5	0	2	3	1	3	1	0	2	5	2	5	0	2	2	2	0	2	3	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:34125518A>T	uc011kap.1	+	13	1673	c.1559A>T	c.(1558-1560)GAT>GTT	p.D520V		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	520	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						TTTGATGTGGATGACTTTGCT	0.468													27	88					0	0	0	0	T	34125518	T	T	34125518	3	4	156	1	0	0	0	0	1	0	0	0	1471	333	12	5	1609	5	BMPER	7	34125518	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	12485802	34125518	125013145	65	28882											
AMPH	273	broad.mit.edu	37	chr7	38530746	38530746	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccacagcacatcacatttCtaaaagaaataaagagacca	19	7	4	11	0	2	2	1	0	1	2	3	3	3	2	2	0	1	1	2	0	5	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:38530746C>G	uc003tgu.2	-	5	370	c.301_splice	c.e5-1	p.K101_splice	AMPH_uc003tgv.2_Splice_Site_p.K101_splice	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1						endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CATCACATTTCTAAAAGAAAT	0.353													16	143					0	0	0	0	G	38530746	G	G	38530746	5	3	156	1	0	0	0	0	0	0	1	0	588	927	32	2	1855	2	AMPH	7	38530746	Splice_Site	SNP	C	TCGA-CR-7390-01A-11D-2012-08	4405228	38530746	120607917	66	28883											
TBL2	26608	broad.mit.edu	37	chr7	72988772	72988772	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttgaggcttctccttccGaatccgctgatattgtttct	5	18	8	10	2	2	2	0	2	2	0	5	3	4	2	3	1	0	4	3	1	2	7	rs145718922		TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:72988772G>T	uc003tyh.2	-	2	336	c.202C>A	c.(202-204)CGG>AGG	p.R68R	TBL2_uc011kex.1_Silent_p.R32R|TBL2_uc010lbg.2_5'UTR|TBL2_uc003tyi.2_5'UTR|TBL2_uc011key.1_5'UTR|TBL2_uc010lbh.2_Intron	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	68											0		Lung NSC(55;0.0659)|all_lung(88;0.152)				TTCTCCTTCCGAATCCGCTGA	0.522													14	59					9.31168e-06	3.65852e-05	1	0	T	72988772	T	T	72988772	2	4	156	1	0	0	0	0	0	0	0	1	15708	1057	37	3		3	TBL2	7	72988772	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	34458026	72988772	86149891	67	28884											
GTF2IRD1	9569	broad.mit.edu	37	chr7	73969808	73969808	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtggacgagagcctgaaGagacagggctttcaaggtaa	12	7	15	7	1	1	3	1	1	0	2	1	6	1	4	1	4	1	2	1	4	3	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:73969808G>A	uc003uaq.2	+	19	2445	c.2052G>A	c.(2050-2052)AAG>AAA	p.K684K	GTF2IRD1_uc010lbq.2_Silent_p.K701K|GTF2IRD1_uc003uap.2_Silent_p.K669K|GTF2IRD1_uc003uar.1_Silent_p.K669K	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	684						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						AGAGCCTGAAGAGACAGGGCT	0.607													6	27					0	0	0	0	A	73969808	A	A	73969808	2	1	156	1	0	0	0	0	0	0	0	1	6907	933	33	2		2	GTF2IRD1	7	73969808	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	981036	73969808	85168855	68	28885											
SRRT	51593	broad.mit.edu	37	chr7	100485056	100485056	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagacccagagcaggaagtGgagaagttcgtcacctccaa	15	5	11	10	1	1	3	1	0	0	3	3	5	2	4	3	2	1	2	3	2	4	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:100485056G>A	uc003uwy.2	+	17	2359	c.2091G>A	c.(2089-2091)GTG>GTA	p.V697V	SRRT_uc010lhl.1_Silent_p.V696V|SRRT_uc003uxa.2_Silent_p.V696V|SRRT_uc003uwz.2_Silent_p.V697V	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	697					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						AGCAGGAAGTGGAGAAGTTCG	0.547													31	62					0	0	0	0	A	100485056	A	A	100485056	2	1	156	1	0	0	0	0	0	0	0	1	15238	1335	47	4		4	SRRT	7	100485056	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	26515248	100485056	58653607	69	28886											
DOCK4	9732	broad.mit.edu	37	chr7	111617324	111617324	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accggggtgtctttcttccgAtgtcgatgttccatctgaat	6	15	10	10	3	3	1	0	1	3	0	6	3	5	1	3	2	0	1	3	2	1	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:111617324A>T	uc003vfx.2	-	8	833	c.564T>A	c.(562-564)CAT>CAA	p.H188Q	DOCK4_uc003vfy.2_Missense_Mutation_p.H188Q|DOCK4_uc003vga.1_5'UTR|DOCK4_uc010ljt.1_Missense_Mutation_p.H188Q|DOCK4_uc003vgb.1_Missense_Mutation_p.H112Q	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	188					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CTTTCTTCCGATGTCGATGTT	0.502													5	16					0	0	0	0	T	111617324	T	T	111617324	3	4	156	1	0	0	0	0	1	0	0	0	4711	330	12	5	5516	5	DOCK4	7	111617324	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	11132268	111617324	47521339	70	28887											
TMEM168	64418	broad.mit.edu	37	chr7	112407527	112407527	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcactgtgcgtcccttttCagtccagcagatgttattac	7	16	7	11	1	2	1	2	0	0	1	4	1	4	1	2	0	3	2	2	0	2	5			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:112407527C>T	uc003vgn.2	-	5	2211	c.1819G>A	c.(1819-1821)GAA>AAA	p.E607K	TMEM168_uc010lju.2_Missense_Mutation_p.E607K|TMEM168_uc011kmr.1_Missense_Mutation_p.E223K	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	607						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						CGTCCCTTTTCAGTCCAGCAG	0.463													8	58					0	0	0	0	T	112407527	T	T	112407527	3	4	156	1	0	0	0	0	1	0	0	0	16149	835	29	2	278	2	TMEM168	7	112407527	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	790203	112407527	46731136	71	28888											
TRPV5	56302	broad.mit.edu	37	chr7	142606703	142606703	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattcgcacccacagatcccGgagcgaggccacaggcagcg	11	3	12	15	4	0	1	0	0	0	1	2	3	1	2	3	3	2	2	3	3	1	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:142606703G>A	uc003wby.1	-	14	2112	c.1848C>T	c.(1846-1848)TCC>TCT	p.S616S		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	616	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CACAGATCCCGGAGCGAGGCC	0.597													10	64					0	0	0	0	A	142606703	A	A	142606703	2	1	156	1	0	0	0	0	0	0	0	1	16666	1103	39	1		1	TRPV5	7	142606703	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	30199176	142606703	16531960	72	28889											
ZNF862	643641	broad.mit.edu	37	chr7	149557670	149557670	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatggtttgggcagttccCatggttagtaattgacccca	8	13	11	9	0	1	1	1	1	0	0	2	1	2	1	3	3	0	5	3	3	2	5			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr7:149557670C>A	uc010lpn.2	+	7	1613	c.1421C>A	c.(1420-1422)CCA>CAA	p.P474Q	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	474	TTF-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1						GGGCAGTTCCCATGGTTAGTA	0.473													30	145					7.01153e-11	2.91404e-10	1	0	A	149557670	A	A	149557670	3	1	156	1	0	0	0	0	1	0	0	0	18262	594	21	4	1447	4	ZNF862	7	149557670	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	6950967	149557670	9580993	73	28890											
SNX16	64089	broad.mit.edu	37	chr8	82752108	82752108	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctaactggcccttagaagaAtttgagcttgttgagacact	11	13	9	8	0	1	4	0	2	1	3	1	5	1	4	1	1	2	2	1	1	4	5			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr8:82752108A>T	uc011lft.1	-	3	621	c.114T>A	c.(112-114)AAT>AAA	p.N38K	SNX16_uc003ycn.2_Missense_Mutation_p.N38K|SNX16_uc003yco.2_Missense_Mutation_p.N38K	NM_022133	NP_071416	P57768	SNX16_HUMAN	sorting nexin 16 isoform a	38					cell communication|early endosome to late endosome transport|endosome to lysosome transport|protein targeting to lysosome	early endosome membrane|extrinsic to endosome membrane|late endosome membrane|lysosome	identical protein binding|phosphatidylinositol binding			ovary(1)|pancreas(1)	2						CCTTAGAAGAATTTGAGCTTG	0.393													37	64					0	0	0	0	T	82752108	T	T	82752108	3	4	156	1	0	0	0	0	1	0	0	0	14951	98	4	5	948	5	SNX16	8	82752108	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08		82752108	63611914	74	28891											
GPR172A	79581	broad.mit.edu	37	chr8	145584478	145584478	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcaggtgctgtcgtgggtgCtgtgtcttggcgtgttctcc	1	15	15	10	2	3	0	1	0	2	0	5	0	3	0	1	3	2	3	1	3	0	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr8:145584478C>G	uc003zcc.1	+	5	1298	c.1141C>G	c.(1141-1143)CTG>GTG	p.L381V	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.L381V|GPR172A_uc003zce.1_Missense_Mutation_p.L381V|GPR172A_uc010mfy.1_Missense_Mutation_p.L381V|GPR172A_uc003zcf.1_Missense_Mutation_p.L381V|GPR172A_uc011llc.1_Missense_Mutation_p.L293V	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	381	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			GTCGTGGGTGCTGTGTCTTGG	0.677													18	76					0	0	0	0	G	145584478	G	G	145584478	3	3	156	1	0	0	0	0	1	0	0	0	6707	796	28	4	1155	4	GPR172A	8	145584478	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	62832370	145584478	779544	75	28892											
MPDZ	8777	broad.mit.edu	37	chr9	13107074	13107074	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attgacagcaatgatctgatCgccccttttcagacgtccgt	9	12	8	12	3	2	4	1	3	1	1	4	4	3	4	3	0	1	1	3	0	1	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr9:13107074C>T	uc010mhy.2	-	45	6067	c.6016G>A	c.(6016-6018)GAT>AAT	p.D2006N	MPDZ_uc003zkx.3_Missense_Mutation_p.D230N|MPDZ_uc003zky.3_Missense_Mutation_p.D569N|MPDZ_uc010mib.2_Missense_Mutation_p.D740N|MPDZ_uc010mhx.2_Missense_Mutation_p.D857N|MPDZ_uc011lmm.1_Missense_Mutation_p.D894N|MPDZ_uc003zkz.3_Missense_Mutation_p.D728N|MPDZ_uc010mhz.2_Missense_Mutation_p.D2002N|MPDZ_uc011lmn.1_Missense_Mutation_p.D1973N|MPDZ_uc003zlb.3_Missense_Mutation_p.D2006N	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	2035	PDZ 13.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		ATGATCTGATCGCCCCTTTTC	0.448													63	89					0	0	0	0	T	13107074	T	T	13107074	3	4	156	1	0	0	0	0	1	0	0	0	9775	884	31	1	113	1	MPDZ	9	13107074	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08		13107074	128106357	76	28893											
GBA2	57704	broad.mit.edu	37	chr9	35741826	35741826	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgcggaggacacttgggCgctccagggacaggacttgc	8	6	16	11	2	0	0	0	0	0	0	1	4	1	4	1	5	3	2	1	5	0	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr9:35741826C>T	uc003zxw.2	-	4	1153	c.629G>A	c.(628-630)CGC>CAC	p.R210H	GBA2_uc011lpb.1_Missense_Mutation_p.R210H|GBA2_uc011lpc.1_Missense_Mutation_p.R210H|GBA2_uc011lpd.1_Missense_Mutation_p.R216H|GBA2_uc003zxy.1_5'UTR	NM_020944	NP_065995	Q9HCG7	GBA2_HUMAN	bile acid beta-glucosidase	210	Extracellular (Potential).				bile acid metabolic process|glucosylceramide catabolic process|O-glycoside catabolic process	integral to membrane|microsome|plasma membrane|smooth endoplasmic reticulum	beta-glucosidase activity|glucosylceramidase activity			ovary(3)|skin(1)	4	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GACACTTGGGCGCTCCAGGGA	0.587													15	66					0	0	0	0	T	35741826	T	T	35741826	3	4	156	1	0	0	0	0	1	0	0	0	6302	768	27	1	2210	1	GBA2	9	35741826	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	22634752	35741826	105471605	77	28894											
GOLM1	51280	broad.mit.edu	37	chr9	88650342	88650342	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgacaagctggtctcgcTcagggccctccatctctgga	7	9	12	13	1	3	1	1	1	2	0	6	3	4	3	2	4	1	2	2	4	1	0			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr9:88650342T>A	uc004aol.2	-	8	1154	c.956A>T	c.(955-957)GAG>GTG	p.E319V	GOLM1_uc004aom.2_Missense_Mutation_p.E319V	NM_016548	NP_057632	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1	319	Lumenal (Potential).					Golgi apparatus|integral to plasma membrane					0						CTGGTCTCGCTCAGGGCCCTC	0.647											OREG0019278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	110					0	0	0	0	A	88650342	A	A	88650342	3	1	156	1	0	0	0	0	1	0	0	0	6604	1551	54	5	261	5	GOLM1	9	88650342	Missense_Mutation	SNP	T	TCGA-CR-7390-01A-11D-2012-08	52908516	88650342	52563089	78	28895											
GRIN3A	116443	broad.mit.edu	37	chr9	104499644	104499644	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaccaagtcgagctccatCatttcgccctggctctgggg	6	10	11	14	2	2	1	1	1	1	0	5	2	3	1	3	3	1	2	3	3	1	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr9:104499644C>G	uc004bbp.1	-	1	1219	c.618G>C	c.(616-618)ATG>ATC	p.M206I	GRIN3A_uc004bbq.1_Missense_Mutation_p.M206I	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	206	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CGAGCTCCATCATTTCGCCCT	0.602													36	22					0	0	0	0	G	104499644	G	G	104499644	3	3	156	1	0	0	0	0	1	0	0	0	6822	826	29	2	2765	2	GRIN3A	9	104499644	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	15849302	104499644	36713787	79	28896											
FAM102A	399665	broad.mit.edu	37	chr9	130712747	130712747	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgttcttcgtgtcatatccCtcgagcaggcagcagcgcac	7	10	11	13	3	2	0	1	0	1	0	5	1	3	0	1	1	3	5	1	1	1	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr9:130712747C>T	uc004bsx.1	-	4	448	c.369G>A	c.(367-369)GAG>GAA	p.E123E	FAM102A_uc004bsw.1_5'UTR|FAM102A_uc004bsy.1_5'Flank	NM_001035254	NP_001030331	Q5T9C2	F102A_HUMAN	early estrogen-induced gene 1 protein isoform a	123										ovary(1)	1						TGTCATATCCCTCGAGCAGGC	0.622													10	91					0	0	0	0	T	130712747	T	T	130712747	2	4	156	1	0	0	0	0	0	0	0	1	5410	680	24	4		4	FAM102A	9	130712747	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	26213103	130712747	10500684	80	28897											
NOTCH1	4851	broad.mit.edu	37	chr9	139402771	139402771	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggcactcgcagcggtactGggtgtgggtctgccagcatt	5	9	17	10	2	1	0	0	0	1	0	2	0	1	0	1	5	4	4	1	5	1	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr9:139402771G>A	uc004chz.2	-	20	3238	c.3238C>T	c.(3238-3240)CAG>TAG	p.Q1080*	NOTCH1_uc004cia.1_Nonsense_Mutation_p.Q310*	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1080	Extracellular (Potential).|EGF-like 28.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CAGCGGTACTGGGTGTGGGTC	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			68	64					0	0	0	0	A	139402771	A	A	139402771	4	1	156	1	0	0	0	0	0	1	0	0	10601	1357	47	4	4489	4	NOTCH1	9	139402771	Nonsense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	8690024	139402771	1810660	81	28898											
FBXO18	84893	broad.mit.edu	37	chr10	5951018	5951018	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgtgctgaacctcatacGgtgagctttgcctgtgctgt	5	14	13	9	1	1	2	1	2	0	0	1	2	1	2	2	1	6	3	2	1	2	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:5951018G>A	uc001iis.2	+	4	979	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	FBXO18_uc001iir.2_Missense_Mutation_p.R221Q|FBXO18_uc009xig.2_Missense_Mutation_p.R221Q|FBXO18_uc001iit.2_Missense_Mutation_p.R346Q	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	295					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						AACCTCATACGGTGAGCTTTG	0.478													13	88					0	0	0	0	A	5951018	A	A	5951018	3	1	156	1	0	0	0	0	1	0	0	0	5763	1130	39	1	1060	1	FBXO18	10	5951018	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08		5951018	129583729	82	28899											
RBM17	84991	broad.mit.edu	37	chr10	6148125	6148125	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggcgtaaagacagacatgaAgcaagtgggtttgcaaggag	15	6	15	5	1	0	3	0	1	0	2	0	4	0	4	0	3	2	4	0	3	5	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:6148125A>G	uc001ijb.2	+	5	655	c.429A>G	c.(427-429)GAA>GAG	p.E143E	RBM17_uc010qav.1_Silent_p.E143E	NM_032905	NP_116294	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	143					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						ACAGACATGAAGCAAGTGGGT	0.408													5	18					0	0	0	0	G	6148125	G	G	6148125	2	3	156	1	0	0	0	0	0	0	0	1	13184	69	3	5		5	RBM17	10	6148125	Silent	SNP	A	TCGA-CR-7390-01A-11D-2012-08	197107	6148125	129386622	83	28900											
TAF3	83860	broad.mit.edu	37	chr10	8007660	8007660	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagagaaagagaagagagaGcgagagaagagagaaaaaga	24	0	16	1	1	0	9	0	0	0	9	0	15	0	9	0	0	1	0	0	0	5	0			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:8007660G>A	uc010qbd.1	+	3	2187	c.2187G>A	c.(2185-2187)GAG>GAA	p.E729E		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	729	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						agaagagagagcgagagaaga	0.139													3	21					0	0	0	0	A	8007660	A	A	8007660	2	1	156	1	0	0	0	0	0	0	0	1	15591	962	34	4		4	TAF3	10	8007660	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	1859535	8007660	127527087	84	28901											
CUBN	8029	broad.mit.edu	37	chr10	16918966	16918966	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtagaagttaagcagaacCggcccagcgatggtgagggg	12	5	17	7	2	0	3	0	1	0	2	0	5	0	3	2	4	3	3	2	4	4	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:16918966C>T	uc001ioo.2	-	57	9088	c.9036G>A	c.(9034-9036)CCG>CCA	p.P3012P	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Silent_p.P368P	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3012	CUB 22.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TAAGCAGAACCGGCCCAGCGA	0.483													24	57					0	0	0	0	T	16918966	T	T	16918966	2	4	156	1	0	0	0	0	0	0	0	1	4068	639	23	1		1	CUBN	10	16918966	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	8911306	16918966	118615781	85	28902											
FAM13C	220965	broad.mit.edu	37	chr10	61012750	61012750	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cggtcttcatcagagtcctcTtcctcctgcttatcacaggc	6	13	7	15	1	5	1	3	0	2	1	8	1	8	1	3	2	1	1	3	2	1	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:61012750T>A	uc001jkn.2	-	13	1475	c.1341A>T	c.(1339-1341)GAA>GAT	p.E447D	FAM13C_uc001jko.2_Missense_Mutation_p.E349D|FAM13C_uc010qid.1_Missense_Mutation_p.E363D|FAM13C_uc010qie.1_Missense_Mutation_p.E364D|FAM13C_uc010qif.1_Missense_Mutation_p.E469D	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	447										ovary(2)	2						CAGAGTCCTCTTCCTCCTGCT	0.463													13	65					0	0	0	0	A	61012750	A	A	61012750	3	1	156	1	0	0	0	0	1	0	0	0	5482	1606	56	5	428	5	FAM13C	10	61012750	Missense_Mutation	SNP	T	TCGA-CR-7390-01A-11D-2012-08	44093784	61012750	74521997	86	28903											
PBLD	64081	broad.mit.edu	37	chr10	70044029	70044029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattcccagctctcctcctcGgtgggaacactgaaaagcta	11	9	8	13	1	1	1	0	1	1	0	5	2	3	2	3	2	3	2	3	2	5	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:70044029G>C	uc001jns.1	-	10	975	c.772C>G	c.(772-774)CGA>GGA	p.R258G	PBLD_uc001jnr.1_Missense_Mutation_p.R225G|PBLD_uc001jnt.1_Missense_Mutation_p.R258G	NM_022129	NP_071412	P30039	PBLD_HUMAN	MAWD binding protein isoform a	258					biosynthetic process		isomerase activity			skin(2)|ovary(1)	3						TCTCCTCCTCGGTGGGAACAC	0.423													9	67					0	0	0	0	C	70044029	C	C	70044029	3	2	156	1	0	0	0	0	1	0	0	0	11543	1124	39	3	98	3	PBLD	10	70044029	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	9031279	70044029	65490718	87	28904											
SYNPO2L	79933	broad.mit.edu	37	chr10	75407451	75407451	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccaggttctgtaccagcgaTagcagctcggggttgggcga	7	9	15	10	3	1	0	0	0	1	0	3	2	2	0	2	4	4	5	2	4	2	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:75407451T>C	uc001jut.3	-	4	2111	c.1959A>G	c.(1957-1959)CTA>CTG	p.L653L	SYNPO2L_uc001jus.3_Silent_p.L429L	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	653	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					GTACCAGCGATAGCAGCTCGG	0.632													31	157					0	0	0	0	C	75407451	C	C	75407451	2	2	156	1	0	0	0	0	0	0	0	1	15524	1393	49	5		5	SYNPO2L	10	75407451	Silent	SNP	T	TCGA-CR-7390-01A-11D-2012-08	5363422	75407451	60127296	88	28905											
ZMIZ1	57178	broad.mit.edu	37	chr10	81058853	81058853	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattccctgtgcgggatggCgtggtgctggagcccttccg	4	10	15	12	3	0	0	0	0	0	0	2	2	2	2	3	4	3	1	3	4	0	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:81058853C>T	uc001kaf.2	+	16	2285	c.1713C>T	c.(1711-1713)GGC>GGT	p.G571G	ZMIZ1_uc001kag.2_Silent_p.G447G	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	571					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			TGCGGGATGGCGTGGTGCTGG	0.647													5	48					0	0	0	0	T	81058853	T	T	81058853	2	4	156	1	0	0	0	0	0	0	0	1	17763	755	27	1		1	ZMIZ1	10	81058853	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	5651402	81058853	54475894	89	28906											
FGFBP3	143282	broad.mit.edu	37	chr10	93668075	93668075	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccggtccccatgggtcgctCctcgttggggaccaaggccg	4	7	14	16	4	0	0	0	0	0	0	4	1	2	1	6	5	0	2	6	5	1	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:93668075C>A	uc001khq.3	-	2	834	c.652G>T	c.(652-654)GAG>TAG	p.E218*		NM_152429	NP_689642	Q8TAT2	FGFP3_HUMAN	fibroblast growth factor binding protein 3	218					positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of vascular permeability	extracellular region	fibroblast growth factor binding|heparin binding				0		Colorectal(252;0.162)				ATGGGTCGCTCCTCGTTGGGG	0.667													14	62					1.5842e-08	6.5088e-08	1	0	A	93668075	A	A	93668075	4	1	156	1	0	0	0	0	0	1	0	0	5894	864	30	2	128	2	FGFBP3	10	93668075	Nonsense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	12609222	93668075	41866672	90	28907											
ZNF518A	9849	broad.mit.edu	37	chr10	97917279	97917279	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actcctctgtccactgggcaAggtaatagagctgaagaggg	11	8	13	9	0	1	3	0	1	1	2	3	3	3	3	2	3	1	3	2	3	4	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:97917279A>T	uc001klp.2	+	6	2057	c.1200A>T	c.(1198-1200)CAA>CAT	p.Q400H	ZNF518A_uc001klo.1_Intron|ZNF518A_uc001klq.2_Missense_Mutation_p.Q400H|ZNF518A_uc001klr.2_Missense_Mutation_p.Q400H	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		CCACTGGGCAAGGTAATAGAG	0.403													17	44					0	0	0	0	T	97917279	T	T	97917279	3	4	156	1	0	0	0	0	1	0	0	0	18029	69	3	5	1202	5	ZNF518A	10	97917279	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	4249204	97917279	37617468	91	28908											
ATRNL1	26033	broad.mit.edu	37	chr10	117221532	117221532	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tactgccataaactttatagCaaacccagaacaggtgagga	16	8	8	9	0	0	2	0	1	0	1	0	3	0	3	2	2	6	1	2	2	7	5			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr10:117221532C>A	uc001lcg.2	+	22	3790	c.3404C>A	c.(3403-3405)GCA>GAA	p.A1135E	ATRNL1_uc010qsm.1_Missense_Mutation_p.A264E|ATRNL1_uc010qsn.1_Intron	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1135	Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AACTTTATAGCAAACCCAGAA	0.318													5	41					0.000602214	0.00230315	1	0	A	117221532	A	A	117221532	3	1	156	1	0	0	0	0	1	0	0	0	1209	710	25	4	3490	4	ATRNL1	10	117221532	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	19304253	117221532	18313215	92	28909											
OR51L1	119682	broad.mit.edu	37	chr11	5020608	5020608	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttgctatctgccatccactGcactaccccaccatcctcac	8	10	4	19	0	2	0	1	0	1	0	4	0	4	0	6	0	4	3	6	0	2	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:5020608G>A	uc010qyu.1	+	1	396	c.396G>A	c.(394-396)CTG>CTA	p.L132L		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCATCCACTGCACTACCCCA	0.493													33	155					0	0	0	0	A	5020608	A	A	5020608	2	1	156	1	0	0	0	0	0	0	0	1	11156	1306	46	4		4	OR51L1	11	5020608	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08		5020608	129985908	93	28910											
OR56A4	120793	broad.mit.edu	37	chr11	6024283	6024283	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaacgtagtagagaagtacaGaaacataaaaagtacattct	21	8	7	5	1	1	2	0	0	1	2	1	3	1	2	0	0	4	4	0	0	10	6			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:6024283G>A	uc010qzv.1	-	1	96	c.96C>T	c.(94-96)TTC>TTT	p.F32F		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGAAGTACAGAAACATAAAA	0.433													12	45					0	0	0	0	A	6024283	A	A	6024283	2	1	156	1	0	0	0	0	0	0	0	1	11189	933	33	2		2	OR56A4	11	6024283	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	1003675	6024283	128982233	94	28911											
EIF3F	8665	broad.mit.edu	37	chr11	8008701	8008701	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttagcccagggtttcctgaGtgctcctcgggccaaaagca	8	9	11	13	1	0	1	0	1	0	0	3	1	2	1	4	2	3	3	4	2	3	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:8008701G>A	uc001mfw.2	+						EIF3F_uc010rbj.1_Translation_Start_Site	NM_003754	NP_003745	O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3,							cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(1)	1				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGTTTCCTGAGTGCTCCTCGG	0.527											OREG0020726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	27					0	0	0	0	A	8008701	A	A	8008701	1	1	156	0	1	0	0	0	0	0	0	0	5040	1044	36	4		4	EIF3F	11	8008701	5'Flank	SNP	G	TCGA-CR-7390-01A-11D-2012-08	1984418	8008701	126997815	95	28912											
SBF2	81846	broad.mit.edu	37	chr11	9838470	9838470	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taggtagctgctgttactgaAggaggccgagtgatccttgc	8	11	14	8	1	0	2	0	2	0	0	1	4	1	3	2	3	4	4	2	3	4	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:9838470A>G	uc001mib.2	-	29	4033	c.3895T>C	c.(3895-3897)TTC>CTC	p.F1299L	SBF2_uc001mid.2_5'UTR	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1299	Myotubularin phosphatase.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CTGTTACTGAAGGAGGCCGAG	0.493													16	47					0	0	0	0	G	9838470	G	G	9838470	3	3	156	1	0	0	0	0	1	0	0	0	13924	72	3	5	1702	5	SBF2	11	9838470	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	1829769	9838470	125168046	96	28913											
ABCC8	6833	broad.mit.edu	37	chr11	17428228	17428228	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagtctcttggccaccttCagccctgtccactccacagt	6	11	7	17	0	2	0	1	0	1	0	5	0	4	0	5	1	2	1	5	1	0	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:17428228C>T	uc001mnc.2	-	26	3396	c.3270G>A	c.(3268-3270)CTG>CTA	p.L1090L		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1090	ABC transmembrane type-1 2.|Helical; Name=13; (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGGCCACCTTCAGCCCTGTCC	0.562													9	46					0	0	0	0	T	17428228	T	T	17428228	2	4	156	1	0	0	0	0	0	0	0	1	58	813	29	2		2	ABCC8	11	17428228	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	7589758	17428228	117578288	97	28914											
SLC17A6	57084	broad.mit.edu	37	chr11	22397578	22397578	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgttggctattctcatactAgaggggtagcaatctcattc	9	14	9	9	1	2	1	2	0	2	1	6	1	2	1	0	3	2	4	0	3	5	7			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:22397578A>G	uc001mqk.2	+	10	1638	c.1225A>G	c.(1225-1227)AGA>GGA	p.R409G		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	409	Vesicular (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TTCTCATACTAGAGGGGTAGC	0.383													32	156					0	0	0	0	G	22397578	G	G	22397578	3	3	156	1	0	0	0	0	1	0	0	0	14486	412	15	5	1263	5	SLC17A6	11	22397578	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	4969350	22397578	112608938	98	28915											
FNBP4	23360	broad.mit.edu	37	chr11	47753052	47753052	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttcttcctcttcaccatCtggaaactcccactgagact	8	14	4	15	0	5	1	1	1	4	1	7	3	7	2	3	1	1	0	3	1	1	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:47753052C>G	uc009ylv.2	-	12	2035	c.1882G>C	c.(1882-1884)GAT>CAT	p.D628H	FNBP4_uc001ngj.2_Missense_Mutation_p.D535H|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	628	WW 2.									ovary(1)	1						TCTTCACCATCTGGAAACTCC	0.403													14	78					0	0	0	0	G	47753052	G	G	47753052	3	3	156	1	0	0	0	0	1	0	0	0	5999	913	32	2	1195	2	FNBP4	11	47753052	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	25355474	47753052	87253464	99	28916											
SCYL1	57410	broad.mit.edu	37	chr11	65294570	65294570	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgctttgtagaaaccaacctCttcctggaggagattcaggt	10	11	10	10	1	2	2	1	0	1	2	3	4	3	3	3	3	2	2	3	3	3	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:65294570C>T	uc001oea.1	+	6	908	c.831C>T	c.(829-831)CTC>CTT	p.L277L	SCYL1_uc009yqk.2_Silent_p.L277L|SCYL1_uc001oeb.1_Silent_p.L277L|SCYL1_uc001oec.1_Silent_p.L277L|SCYL1_uc001oed.1_Silent_p.L134L	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	277	Protein kinase.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						AAACCAACCTCTTCCTGGAGG	0.572													8	74					0	0	0	0	T	65294570	T	T	65294570	2	4	156	1	0	0	0	0	0	0	0	1	14012	900	32	2		2	SCYL1	11	65294570	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	17541518	65294570	69711946	100	28917											
NPAS4	266743	broad.mit.edu	37	chr11	66192179	66192179	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggatgtccccctggtgccCgaaggcctgctcacacctga	6	8	12	15	1	1	1	1	1	0	0	2	3	2	2	5	3	2	1	5	3	1	0	rs141846354		TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:66192179C>T	uc001ohx.1	+	7	1994	c.1818C>T	c.(1816-1818)CCC>CCT	p.P606P	NPAS4_uc010rpc.1_Silent_p.P396P	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	606					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CCCTGGTGCCCGAAGGCCTGC	0.587													57	108					0	0	0	0	T	66192179	T	T	66192179	2	4	156	1	0	0	0	0	0	0	0	1	10619	639	23	1		1	NPAS4	11	66192179	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	897609	66192179	68814337	101	28918											
CNTN5	53942	broad.mit.edu	37	chr11	100169983	100169983	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtggctggaaggaaaaaatGgtgacatcctctgaagcttc	12	9	12	8	1	1	2	0	2	1	0	3	4	2	4	1	4	1	2	1	4	5	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:100169983G>T	uc001pga.2	+	20	2814	c.2475G>T	c.(2473-2475)ATG>ATT	p.M825I	CNTN5_uc001pfz.2_Missense_Mutation_p.M825I|CNTN5_uc001pgb.2_Missense_Mutation_p.M751I|CNTN5_uc010ruk.1_Missense_Mutation_p.M96I	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	825	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGGAAAAAATGGTGACATCCT	0.423													7	31					8.12818e-05	0.000315901	1	0	T	100169983	T	T	100169983	3	4	156	1	0	0	0	0	1	0	0	0	3659	1348	47	4	2545	4	CNTN5	11	100169983	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	33977804	100169983	34836533	102	28919											
CEP164	22897	broad.mit.edu	37	chr11	117266774	117266780	+	Frame_Shift_Del	DEL	CTGGAGG	-	-																															atctttccttccacagcagcCtggaggctgaagctcaaaag																										TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr11:117266774_117266780delCTGGAGG	uc001prc.2	+	25	3241_3247	c.3094_3100delCTGGAGG	c.(3094-3102)CTGGAGGCTfs	p.L1032fs	CEP164_uc001prb.2_Frame_Shift_Del_p.L1035fs|CEP164_uc010rxk.1_Frame_Shift_Del_p.L1006fs|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_Frame_Shift_Del_p.L465fs	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1032_1034					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		CCACAGCAGCCTGGAGGCTGAAGCTCA	0.546													---	---	---								-	117266780	-	-	117266774	7	5	156	1	0	1	0	1	0	0	0	0	3264	680	24	0	3184	0	CEP164	11	117266774	Frame_Shift_Del	DEL	CTGGAGG	TCGA-CR-7390-01A-11D-2012-08	17096791	117266774	17739742	103	28920											
RAD52	5893	broad.mit.edu	37	chr12	1023104	1023104	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aagtttggaggtcccaagatCcagattttgcttgtggtttc	8	15	11	7	0	0	2	0	0	0	2	3	3	2	3	2	3	1	3	2	3	2	5			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr12:1023104C>A	uc001qis.1	-	11	1265	c.1151G>T	c.(1150-1152)GGA>GTA	p.G384V	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Missense_Mutation_p.G307V|RAD52_uc001qiu.1_Missense_Mutation_p.G384V|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_RNA	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	384					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			GTCCCAAGATCCAGATTTTGC	0.488								Homologous_recombination					29	65					3.57733e-08	1.46142e-07	1	0	A	1023104	A	A	1023104	3	1	156	1	0	0	0	0	1	0	0	0	13056	855	30	2	113	2	RAD52	12	1023104	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08		1023104	132828791	104	28921											
TSPAN9	10867	broad.mit.edu	37	chr12	3387622	3387622	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgctgggagtgggcatctgGctctccgtgtcccaaggcaa	6	9	14	12	1	2	0	0	0	2	0	4	1	3	1	2	4	1	4	2	4	2	0			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr12:3387622G>A	uc001qlp.2	+	4	246	c.99G>A	c.(97-99)TGG>TGA	p.W33*		NM_006675	NP_006666	O75954	TSN9_HUMAN	tetraspanin 9	33	Helical; (Potential).					integral to plasma membrane|membrane fraction				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			TGGGCATCTGGCTCTCCGTGT	0.577													38	118					0	0	0	0	A	3387622	A	A	3387622	4	1	156	1	0	0	0	0	0	1	0	0	16721	1212	42	4	105	4	TSPAN9	12	3387622	Nonsense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	2364518	3387622	130464273	105	28922											
C12orf71	728858	broad.mit.edu	37	chr12	27235255	27235255	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgccccttggacgggaggCagaaagtggatggaaggacc	11	5	16	9	1	0	1	0	0	0	1	0	6	0	6	3	6	1	1	3	6	2	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr12:27235255C>G	uc001rhq.2	-	1	201	c.162G>C	c.(160-162)CTG>CTC	p.L54L		NM_001080406	NP_001073875	A8MTZ7	CL071_HUMAN	hypothetical protein LOC728858	54											0						GGACGGGAGGCAGAAAGTGGA	0.537													3	65					0	0	0	0	G	27235255	G	G	27235255	2	3	156	1	0	0	0	0	0	0	0	1	1718	697	25	4		4	C12orf71	12	27235255	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	23847633	27235255	106616640	106	28923											
MAP3K12	7786	broad.mit.edu	37	chr12	53876495	53876495	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggccctactggaggaggtgGttcccctttggctcccccag	5	9	13	14	0	0	0	0	0	0	0	2	2	2	2	5	6	1	2	5	6	1	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr12:53876495G>T	uc001sdm.1	-	12	2091	c.1993C>A	c.(1993-1995)CCA>ACA	p.P665T	MAP3K12_uc001sdn.1_Missense_Mutation_p.P698T	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	665	Poly-Pro.				histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						GGAGGAGGTGGTTCCCCTTTG	0.672													25	94					1.5548e-18	6.69402e-18	1	0	T	53876495	T	T	53876495	3	4	156	1	0	0	0	0	1	0	0	0	9299	1261	44	4	602	4	MAP3K12	12	53876495	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	26641240	53876495	79975400	107	28924											
OR6C65	403282	broad.mit.edu	37	chr12	55794454	55794454	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatcatcattatgttaacaTtgtcaaatattcatttgaaa	15	17	4	5	0	4	2	4	2	0	0	4	2	4	2	0	0	1	1	0	0	5	6			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr12:55794454T>A	uc010spl.1	+	1	142	c.142T>A	c.(142-144)TTG>ATG	p.L48M		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TATGTTAACATTGTCAAATAT	0.299													11	19					0	0	0	0	A	55794454	A	A	55794454	3	1	156	1	0	0	0	0	1	0	0	0	11249	1490	52	5	144	5	OR6C65	12	55794454	Missense_Mutation	SNP	T	TCGA-CR-7390-01A-11D-2012-08	1917959	55794454	78057441	108	28925											
ASCL1	429	broad.mit.edu	37	chr12	103352724	103352724	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagcttctcgacttcaccaaCtggttctgaggggctcggcc	6	10	12	13	2	3	1	1	1	2	0	5	3	3	1	2	4	2	3	2	4	1	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr12:103352724C>G	uc001tjr.3	+	1	1273	c.702C>G	c.(700-702)AAC>AAG	p.N234K		NM_004316	NP_004307	P50553	ASCL1_HUMAN	achaete-scute complex homolog 1	234					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity				0						ACTTCACCAACTGGTTCTGAG	0.617													6	34					0	0	0	0	G	103352724	G	G	103352724	3	3	156	1	0	0	0	0	1	0	0	0	1036	564	20	4	704	4	ASCL1	12	103352724	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	47558270	103352724	30499171	109	28926											
CMKLR1	1240	broad.mit.edu	37	chr12	108686177	108686177	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggctgaagttgttgaagcagGatattttcccatgcaggttg	9	13	13	6	0	0	2	0	2	0	0	1	3	1	3	1	3	2	6	1	3	3	6			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr12:108686177G>A	uc009zuw.2	-	3	754	c.563C>T	c.(562-564)TCC>TTC	p.S188F	CMKLR1_uc001tmw.2_Missense_Mutation_p.S188F|CMKLR1_uc001tmv.2_Missense_Mutation_p.S186F|CMKLR1_uc009zuv.2_Missense_Mutation_p.S188F	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	188	Extracellular (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						GTTGAAGCAGGATATTTTCCC	0.557													6	41					0	0	0	0	A	108686177	A	A	108686177	3	1	156	1	0	0	0	0	1	0	0	0	3594	1174	41	2	562	2	CMKLR1	12	108686177	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	5333453	108686177	25165718	110	28927											
CENPJ	55835	broad.mit.edu	37	chr13	25483949	25483949	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtaggatggttacggttttCttcttttaaattattttttt	7	24	7	3	1	2	0	0	0	2	0	2	1	2	1	0	3	1	3	0	3	5	11			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr13:25483949C>T	uc001upt.3	-	4	1097	c.844G>A	c.(844-846)GAA>AAA	p.E282K	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	282					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		TTACGGTTTTCTTCTTTTAAA	0.353													3	14					0	0	0	0	T	25483949	T	T	25483949	3	4	156	1	0	0	0	0	1	0	0	0	3249	922	32	2	3228	2	CENPJ	13	25483949	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08		25483949	89685929	111	28928											
KLHL1	57626	broad.mit.edu	37	chr13	70370888	70370888	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctagaccatgtctgtgtgTtgacattggtggtaagacag	10	12	12	7	0	1	3	0	1	1	2	1	3	1	3	2	2	0	2	2	2	2	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr13:70370888T>C	uc001vip.2	-	7	2415	c.1621A>G	c.(1621-1623)ACA>GCA	p.T541A	KLHL1_uc010thm.1_Missense_Mutation_p.T480A	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	541	Kelch 2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TGTCTGTGTGTTGACATTGGT	0.323													5	48					0	0	0	0	C	70370888	C	C	70370888	3	2	156	1	0	0	0	0	1	0	0	0	8404	1725	60	5	645	5	KLHL1	13	70370888	Missense_Mutation	SNP	T	TCGA-CR-7390-01A-11D-2012-08	44886939	70370888	44798990	112	28929											
SLC7A8	23428	broad.mit.edu	37	chr14	23608670	23608670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgccagcagctcctgggggGacattgcagtgacataagcg	10	7	14	10	1	0	1	0	1	0	0	1	2	1	2	2	3	5	3	2	3	1	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr14:23608670G>A	uc001wiz.2	-	6	1601	c.875C>T	c.(874-876)TCC>TTC	p.S292F	SLC7A8_uc001wix.2_Missense_Mutation_p.S89F|SLC7A8_uc010tnk.1_Missense_Mutation_p.S68F|SLC7A8_uc010tnl.1_Missense_Mutation_p.S187F|SLC7A8_uc001wiy.2_Intron|SLC7A8_uc010akj.2_Intron	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	292					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	CTCCTGGGGGGACATTGCAGT	0.517													19	130					0	0	0	0	A	23608670	A	A	23608670	3	1	156	1	0	0	0	0	1	0	0	0	14768	1174	41	2	756	2	SLC7A8	14	23608670	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08		23608670	83740870	113	28930											
MYH7	4625	broad.mit.edu	37	chr14	23902836	23902836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcatcaggcacgaagacatCcttcttgaggtcaaaaggcc	12	8	10	11	1	4	2	3	1	1	1	5	3	5	2	2	3	0	1	2	3	3	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr14:23902836C>T	uc001wjx.2	-	3	212	c.106G>A	c.(106-108)GAT>AAT	p.D36N		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	36	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ACGAAGACATCCTTCTTGAGG	0.567													18	106					0	0	0	0	T	23902836	T	T	23902836	3	4	156	1	0	0	0	0	1	0	0	0	10092	855	30	2	5853	2	MYH7	14	23902836	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	294166	23902836	83446704	114	28931											
AP1G2	8906	broad.mit.edu	37	chr14	24030798	24030798	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttgcttcctcatcagcctGagggccatctcgctccacaa	7	11	7	16	1	3	1	2	1	1	0	6	1	5	1	4	1	2	2	4	1	1	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr14:24030798G>A	uc001wkl.2	-	18	2117	c.1780C>T	c.(1780-1782)CAG>TAG	p.Q594*	AP1G2_uc001wkj.2_Nonsense_Mutation_p.Q213*|AP1G2_uc001wkk.3_Nonsense_Mutation_p.Q522*|AP1G2_uc001wkn.2_Nonsense_Mutation_p.Q213*|uc001wko.1_RNA|AP1G2_uc001wkp.1_RNA	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	594					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		TCATCAGCCTGAGGGCCATCT	0.557													8	36					0	0	0	0	A	24030798	A	A	24030798	4	1	156	1	0	0	0	0	0	1	0	0	733	1299	45	2	597	2	AP1G2	14	24030798	Nonsense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	127962	24030798	83318742	115	28932											
ARHGAP5	394	broad.mit.edu	37	chr14	32561108	32561108	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgagcactttagaagctgaAaaagtctatcagaaccatgt	15	10	8	8	0	2	4	1	2	1	2	2	4	2	4	1	0	3	2	1	0	6	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr14:32561108A>G	uc001wrl.2	+	2	1472	c.1233A>G	c.(1231-1233)GAA>GAG	p.E411E	ARHGAP5_uc001wrm.2_Silent_p.E411E|ARHGAP5_uc001wrn.2_Silent_p.E411E|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	411	FF 2.				cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TAGAAGCTGAAAAAGTCTATC	0.368													37	75					0	0	0	0	G	32561108	G	G	32561108	2	3	156	1	0	0	0	0	0	0	0	1	886	11	1	5		5	ARHGAP5	14	32561108	Silent	SNP	A	TCGA-CR-7390-01A-11D-2012-08	8530310	32561108	74788432	116	28933											
LRFN5	145581	broad.mit.edu	37	chr14	42356819	42356819	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagggaagcttatttcaaatGcaacaagatctctggtgtat	14	12	9	6	0	2	1	1	0	1	1	3	2	2	2	0	2	3	3	0	2	7	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr14:42356819G>T	uc001wvm.2	+	3	2189	c.991G>T	c.(991-993)GCA>TCA	p.A331S	LRFN5_uc010ana.2_Missense_Mutation_p.A331S	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	331	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TATTTCAAATGCAACAAGATC	0.468										HNSCC(30;0.082)			11	77					0.000978159	0.00372114	1	0	T	42356819	T	T	42356819	3	4	156	1	0	0	0	0	1	0	0	0	8991	1319	46	4	993	4	LRFN5	14	42356819	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	9795711	42356819	64992721	117	28934											
FOS	2353	broad.mit.edu	37	chr14	75746697	75746698	+	Missense_Mutation	DNP	CC	AG	AG																															ccctcgtctcctccgtggccCcatcgcagaccagagcccct																										TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr14:75746697_75746698CC>AG	uc001xrn.2	+	2	464_465	c.259_260CC>AG	c.(259-261)CCA>AGA	p.P87R	FOS_uc010tva.1_Missense_Mutation_p.P87R|FOS_uc010asi.2_5'UTR|FOS_uc001xro.2_5'Flank	NM_005252	NP_005243	P01100	FOS_HUMAN	v-fos FBJ murine osteosarcoma viral oncogene	87					cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(2)|ovary(1)	3		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		CTCCGTGGCCCCATCGCAGACC	0.673													8	64					0	0	0	0	AG	75746698	AG	AG	75746697	3	1	156	1	0	0	0	0	1	0	0	0	6017	623	22	4	265	4	FOS	14	75746697	Missense_Mutation	DNP	CC	TCGA-CR-7390-01A-11D-2012-08	33389878	75746697	31602843	118	28935											
TP53BP1	7158	broad.mit.edu	37	chr15	43762178	43762178	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcaggagaggggggttttCtaactccactggttcaccac	9	9	13	10	0	2	1	1	0	1	1	3	2	3	1	2	6	1	3	2	6	1	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr15:43762178C>T	uc001zrs.2	-	11	1400	c.1252G>A	c.(1252-1254)GAA>AAA	p.E418K	TP53BP1_uc010udp.1_Missense_Mutation_p.E418K|TP53BP1_uc001zrq.3_Missense_Mutation_p.E423K|TP53BP1_uc001zrr.3_Missense_Mutation_p.E423K|TP53BP1_uc010udq.1_Missense_Mutation_p.E423K	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	418					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GGGGGGTTTTCTAACTCCACT	0.483								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					19	118					0	0	0	0	T	43762178	T	T	43762178	3	4	156	1	0	0	0	0	1	0	0	0	16450	922	32	2	4738	2	TP53BP1	15	43762178	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08		43762178	58769214	119	28936											
HDC	3067	broad.mit.edu	37	chr15	50534531	50534531	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcattcaggaaagctggggaCgctgtagaatttgatgagtt	11	11	14	5	1	1	3	1	2	0	1	1	5	1	5	0	3	1	5	0	3	3	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr15:50534531C>T	uc001zxz.2	-	12	2021	c.1915G>A	c.(1915-1917)GTC>ATC	p.V639I	HDC_uc001zxy.2_Missense_Mutation_p.V382I|HDC_uc010uff.1_Missense_Mutation_p.V606I	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	639					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	AAGCTGGGGACGCTGTAGAAT	0.438													23	125					0	0	0	0	T	50534531	T	T	50534531	3	4	156	1	0	0	0	0	1	0	0	0	7054	536	19	1	77	1	HDC	15	50534531	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	6772353	50534531	51996861	120	28937											
NPTN	27020	broad.mit.edu	37	chr15	73925476	73925476	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccgcttaccgttctgagcGgcgcctggccctgggaggag	4	7	15	15	4	1	1	0	1	1	0	1	3	1	3	5	4	2	2	5	4	1	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr15:73925476G>C	uc002avs.2	-	1	278	c.81C>G	c.(79-81)GCC>GCG	p.A27A	NPTN_uc010bjc.2_Silent_p.A27A|NPTN_uc002avt.2_Silent_p.A27A|NPTN_uc002avr.2_Silent_p.A27A|NPTN_uc010ula.1_Silent_p.A27A	NM_012428	NP_036560	Q9Y639	NPTN_HUMAN	neuroplastin isoform b precursor	27					elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding				0						CGTTCTGAGCGGCGCCTGGCC	0.463													15	19					0	0	0	0	C	73925476	C	C	73925476	2	2	156	1	0	0	0	0	0	0	0	1	10655	1103	39	3		3	NPTN	15	73925476	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	23390945	73925476	28605916	121	28938											
ARL6IP1	23204	broad.mit.edu	37	chr16	18806883	18806883	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctgcaaatttcatggaatCtttgctgttgttcagtggtc	7	17	10	7	0	3	0	2	0	1	0	4	1	3	1	0	2	3	5	0	2	2	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr16:18806883C>G	uc002dfl.1	-	4	380	c.311G>C	c.(310-312)AGA>ACA	p.R104T	ARL6IP1_uc010van.1_Missense_Mutation_p.R75T|ARL6IP1_uc010bvz.1_Intron	NM_015161	NP_055976	Q15041	AR6P1_HUMAN	ADP-ribosylation factor-like 6 interacting	104						integral to membrane	protein binding				0						TTCATGGAATCTTTGCTGTTG	0.388													4	30					0	0	0	0	G	18806883	G	G	18806883	3	3	156	1	0	0	0	0	1	0	0	0	944	913	32	2	312	2	ARL6IP1	16	18806883	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08		18806883	71547870	122	28939											
CD2BP2	10421	broad.mit.edu	37	chr16	30364884	30364884	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggccaccatctggtcggccaAcccggagagccggtccaggc	7	4	14	16	3	1	1	0	0	1	1	3	2	2	1	6	6	2	0	6	6	1	0			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr16:30364884A>C	uc002dxr.2	-	4	866	c.613T>G	c.(613-615)TTG>GTG	p.L205V	CD2BP2_uc002dxs.2_Missense_Mutation_p.L205V	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	205					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						TGGTCGGCCAACCCGGAGAGC	0.657													10	22					0	0	0	0	C	30364884	C	C	30364884	3	2	156	1	0	0	0	0	1	0	0	0	3010	40	2	5	424	5	CD2BP2	16	30364884	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	11558001	30364884	59989869	123	28940											
ITFG1	81533	broad.mit.edu	37	chr16	47196540	47196540	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagcacgttgtatggtagttGgagagctaaatgtgcggatt	11	12	14	4	2	0	1	0	0	0	1	0	3	0	2	0	3	3	6	0	3	5	6			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr16:47196540G>A	uc002eet.2	-	15	1551	c.1489C>T	c.(1489-1491)CAA>TAA	p.Q497*	ITFG1_uc010vgg.1_Nonsense_Mutation_p.Q242*|ITFG1_uc010vgh.1_Nonsense_Mutation_p.Q384*	NM_030790	NP_110417	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	497						extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				TATGGTAGTTGGAGAGCTAAA	0.393													19	77					0	0	0	0	A	47196540	A	A	47196540	4	1	156	1	0	0	0	0	0	1	0	0	7908	1357	47	4	365	4	ITFG1	16	47196540	Nonsense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	16831656	47196540	43158213	124	28941											
CPNE2	221184	broad.mit.edu	37	chr16	57147238	57147238	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgatcaacaacctcaacccCgccttctccaagaagttcgt	11	8	6	16	3	3	1	2	0	1	1	5	2	3	1	5	0	3	1	5	0	5	2	rs138897886		TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr16:57147238C>T	uc002eks.1	+	3	448	c.219C>T	c.(217-219)CCC>CCT	p.P73P	CPNE2_uc010cct.1_Silent_p.P99P|CPNE2_uc010ccu.1_Silent_p.P73P	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	73	C2 1.									central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				ACCTCAACCCCGCCTTCTCCA	0.552													9	66					0	0	0	0	T	57147238	T	T	57147238	2	4	156	1	0	0	0	0	0	0	0	1	3827	639	23	1		1	CPNE2	16	57147238	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	9950698	57147238	33207515	125	28942											
FOXC2	2303	broad.mit.edu	37	chr16	86600960	86600960	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatgcaggcgcgctactccGtgtccgaccccaacgccctg	6	6	11	18	5	0	0	0	0	0	0	2	1	2	0	5	1	3	3	5	1	2	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr16:86600960G>A	uc002fjq.2	+	1	104	c.19G>A	c.(19-21)GTG>ATG	p.V7M		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	7					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						GCGCTACTCCGTGTCCGACCC	0.592									Late-onset_Hereditary_Lymphedema				15	55					0	0	0	0	A	86600960	A	A	86600960	3	1	156	1	0	0	0	0	1	0	0	0	6027	1145	40	1	21	1	FOXC2	16	86600960	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	29453722	86600960	3753793	126	28943											
ANKRD11	29123	broad.mit.edu	37	chr16	89348862	89348862	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctctttcttggctcgctctCggtcgtggctcttcttggat	1	18	10	12	3	5	0	0	0	5	0	9	1	5	1	0	4	0	3	0	4	0	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr16:89348862C>T	uc002fmx.1	-	9	4549	c.4088G>A	c.(4087-4089)CGA>CAA	p.R1363Q	ANKRD11_uc002fmy.1_Missense_Mutation_p.R1363Q|ANKRD11_uc002fnc.1_Missense_Mutation_p.R1363Q|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.R1320Q	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1363	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GGCTCGCTCTCGGTCGTGGCT	0.562													20	106					0	0	0	0	T	89348862	T	T	89348862	3	4	156	1	0	0	0	0	1	0	0	0	639	884	31	1	3923	1	ANKRD11	16	89348862	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	2747902	89348862	1005891	127	28944											
ANKRD11	29123	broad.mit.edu	37	chr16	89351117	89351117	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcgccctccgcgctggacagGaaggggctcttcttctccga	5	8	13	15	4	3	0	0	0	3	0	5	3	4	2	3	4	0	2	3	4	1	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr16:89351117G>A	uc002fmx.1	-	9	2294	c.1833C>T	c.(1831-1833)TTC>TTT	p.F611F	ANKRD11_uc002fmy.1_Silent_p.F611F|ANKRD11_uc002fnc.1_Silent_p.F611F|ANKRD11_uc002fnb.1_Silent_p.F568F	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	611						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CGCTGGACAGGAAGGGGCTCT	0.537													12	65					0	0	0	0	A	89351117	A	A	89351117	2	1	156	1	0	0	0	0	0	0	0	1	639	1165	41	2		2	ANKRD11	16	89351117	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	2255	89351117	1003636	128	28945											
TP53	7157	broad.mit.edu	37	chr17	7579369	7579369	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagcccagacggaaaccgtaGctgccctggtaggttttctg	9	9	12	11	2	1	1	0	0	1	1	1	2	1	2	3	3	4	4	3	3	4	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:7579369G>C	uc002gim.2	-	4	512	c.318C>G	c.(316-318)AGC>AGG	p.S106R	TP53_uc002gig.1_Missense_Mutation_p.S106R|TP53_uc002gih.2_Missense_Mutation_p.S106R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.S106R|TP53_uc010cni.1_Missense_Mutation_p.S106R|TP53_uc002gij.2_Missense_Mutation_p.S106R|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.S67R|TP53_uc010cnk.1_Missense_Mutation_p.S121R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	106	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		S -> R (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|S -> G (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G59fs*23(3)|p.S106R(3)|p.V73fs*9(1)|p.S106fs*17(1)|p.S106_Y107delSY(1)|p.G105_T125del21(1)|p.Y107fs*44(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y103_L111>L(1)|p.Y103fs*15(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAAACCGTAGCTGCCCTGGT	0.617		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			42	29					0	0	0	0	C	7579369	C	C	7579369	3	2	156	1	0	0	0	0	1	0	0	0	16448	962	34	4	984	4	TP53	17	7579369	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08		7579369	73615841	129	28946											
MYH4	4622	broad.mit.edu	37	chr17	10352202	10352202	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtcaaagtttctttgcttCttatcgagagctatgcaggc	8	16	9	8	1	3	1	1	0	2	1	4	2	3	1	0	1	3	4	0	1	3	6			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:10352202C>T	uc002gmn.2	-	31	4455	c.4344G>A	c.(4342-4344)AAG>AAA	p.K1448K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1448	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TTCTTTGCTTCTTATCGAGAG	0.433													4	52					0	0	0	0	T	10352202	T	T	10352202	2	4	156	1	0	0	0	0	0	0	0	1	10090	912	32	2		2	MYH4	17	10352202	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	2772833	10352202	70843008	130	28947											
TMEM132E	124842	broad.mit.edu	37	chr17	32964569	32964569	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctggcccgccgggctctgCgctacccgcaccggaggctc	4	5	14	18	5	1	0	0	0	1	0	2	1	1	1	4	4	3	5	4	4	1	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:32964569C>T	uc002hif.2	+	10	2601	c.2273C>T	c.(2272-2274)GCG>GTG	p.A758V		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	758	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCGGGCTCTGCGCTACCCGCA	0.746													5	17					0	0	0	0	T	32964569	T	T	32964569	3	4	156	1	0	0	0	0	1	0	0	0	16114	768	27	1	2311	1	TMEM132E	17	32964569	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	22612367	32964569	48230641	131	28948											
KRT37	8688	broad.mit.edu	37	chr17	39580043	39580043	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagtcatcagcagccagcttCgcgttgtcaatttgtacaat	11	12	8	10	2	3	0	3	0	0	0	4	0	3	0	1	0	4	4	1	0	4	4			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:39580043C>T	uc002hwp.1	-	2	593	c.546G>A	c.(544-546)GCG>GCA	p.A182A	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	182	Rod.|Coil 1B.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				CAGCCAGCTTCGCGTTGTCAA	0.328													12	63					0	0	0	0	T	39580043	T	T	39580043	2	4	156	1	0	0	0	0	0	0	0	1	8513	871	31	1		1	KRT37	17	39580043	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	6615474	39580043	41615167	132	28949											
KRT14	3861	broad.mit.edu	37	chr17	39742774	39742785	+	In_Frame_Del	DEL	CAAAGCCACCAC	-	-																															cagaagcccatcaccaccagCaaagccaccaccaaagccac																										TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:39742774_39742785delCAAAGCCACCAC	uc002hxf.1	-	1	363_374	c.302_313delGTGGTGGCTTTG	c.(301-315)GGTGGTGGCTTTGCT>GCT	p.GGGF101del	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_In_Frame_Del_p.GGGF101del	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	101_104	Head.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				tcaccaccagcaaagccaccaccaaagccacc	0.349													---	---	---								-	39742785	-	-	39742774	7	5	156	1	0	1	0	1	0	0	0	0	8490	710	25	0	1137	0	KRT14	17	39742774	In_Frame_Del	DEL	CAAAGCCACCAC	TCGA-CR-7390-01A-11D-2012-08	162731	39742774	41452436	133	28950											
NKIRAS2	28511	broad.mit.edu	37	chr17	40175777	40175777	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagagaaggtgaagctgtggGaggtgtcagtggcggaccgg	9	6	20	6	2	1	2	1	1	0	1	1	5	1	4	1	6	1	1	1	6	2	0			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:40175777G>T	uc002hyq.2	+	4	507	c.442G>T	c.(442-444)GAG>TAG	p.E148*	NKIRAS2_uc010wgd.1_3'UTR|NKIRAS2_uc002hyr.2_Nonsense_Mutation_p.E148*|NKIRAS2_uc002hys.2_Nonsense_Mutation_p.E148*|NKIRAS2_uc010wge.1_Nonsense_Mutation_p.E92*|NKIRAS2_uc002hyt.2_Nonsense_Mutation_p.E148*	NM_001001349	NP_001001349	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2 isoform a	148	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			ovary(1)	1		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				GAAGCTGTGGGAGGTGTCAGT	0.607													12	64					2.61681e-11	1.09389e-10	1	0	T	40175777	T	T	40175777	4	4	156	1	0	0	0	0	0	1	0	0	10499	1175	41	2	452	2	NKIRAS2	17	40175777	Nonsense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	433003	40175777	41019433	134	28951											
KPNB1	3837	broad.mit.edu	37	chr17	45745744	45745744	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgtatcttggaaggaccaGagcccagtcagctcaaacca	12	8	10	11	0	3	1	2	0	1	1	3	3	3	3	3	2	3	3	3	2	3	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:45745744G>C	uc002ilt.1	+	10	1528	c.1192G>C	c.(1192-1194)GAG>CAG	p.E398Q	KPNB1_uc010wkw.1_Missense_Mutation_p.E253Q|KPNB1_uc010wkx.1_Missense_Mutation_p.E182Q	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	398	Ran-GTP binding.|HEAT 5.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						GGAAGGACCAGAGCCCAGTCA	0.423													9	65					0	0	0	0	C	45745744	C	C	45745744	3	2	156	1	0	0	0	0	1	0	0	0	8474	943	33	2	1230	2	KPNB1	17	45745744	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	5569967	45745744	35449466	135	28952											
MPO	4353	broad.mit.edu	37	chr17	56355308	56355308	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctggttgacggccagcaGccccagctggttggacatgt	6	8	15	12	2	0	1	0	1	0	0	0	2	0	2	3	4	3	5	3	4	0	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:56355308G>A	uc002ivu.1	-	7	1261	c.1084C>T	c.(1084-1086)CTG>TTG	p.L362L		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	362					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	ACGGCCAGCAGCCCCAGCTGG	0.647													12	63					0	0	0	0	A	56355308	A	A	56355308	2	1	156	1	0	0	0	0	0	0	0	1	9785	962	34	4		4	MPO	17	56355308	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	10609564	56355308	24839902	136	28953											
C17orf77	146723	broad.mit.edu	37	chr17	72588200	72588200	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcatggatggatgaattggcGctgtcattttccctgacatg	8	13	12	8	1	1	2	1	2	0	0	2	4	2	4	1	3	0	2	1	3	1	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:72588200G>A	uc002jla.1	+	3	377	c.15G>A	c.(13-15)GCG>GCA	p.A5A	CD300LD_uc002jkz.2_Intron	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	5						extracellular region					0						ATGAATTGGCGCTGTCATTTT	0.453													21	159					0	0	0	0	A	72588200	A	A	72588200	2	1	156	1	0	0	0	0	0	0	0	1	1890	1074	38	1		1	C17orf77	17	72588200	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	16232892	72588200	8607010	137	28954											
GGA3	23163	broad.mit.edu	37	chr17	73235980	73235980	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctcaacttttggggccaaGgctggggccactccagtaga	8	8	14	11	0	1	1	1	0	0	1	2	1	2	1	3	6	1	3	3	6	3	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:73235980G>A	uc002jni.1	-	13	1482	c.1473C>T	c.(1471-1473)GCC>GCT	p.A491A	GGA3_uc002jnj.1_Silent_p.A458A|GGA3_uc010wrw.1_Silent_p.A369A|GGA3_uc002jnk.1_Silent_p.A419A|GGA3_uc010wrx.1_Silent_p.A369A|GGA3_uc010wry.1_Silent_p.A419A	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	491	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			TTGGGGCCAAGGCTGGGGCCA	0.637													5	33					0	0	0	0	A	73235980	A	A	73235980	2	1	156	1	0	0	0	0	0	0	0	1	6391	987	35	4		4	GGA3	17	73235980	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	647780	73235980	7959230	138	28955											
TNRC6C	57690	broad.mit.edu	37	chr17	76045219	76045219	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaataatggcaccaatggcGcactcgtccaaagcccttct	11	8	8	14	2	1	0	0	0	1	0	3	0	2	0	3	2	1	3	3	2	4	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr17:76045219G>A	uc002jud.2	+	4	676	c.76G>A	c.(76-78)GCA>ACA	p.A26T	TNRC6C_uc002juf.2_Missense_Mutation_p.A26T|TNRC6C_uc002jue.2_Missense_Mutation_p.A26T	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	26	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CACCAATGGCGCACTCGTCCA	0.552													13	74					0	0	0	0	A	76045219	A	A	76045219	3	1	156	1	0	0	0	0	1	0	0	0	16408	1087	38	1	78	1	TNRC6C	17	76045219	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	2809239	76045219	5149991	139	28956											
LAMA3	3909	broad.mit.edu	37	chr18	21330996	21330996	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcgttttcttagaaccaatAcgcttcttggacacctcatc	9	14	6	12	2	3	1	1	0	2	1	4	2	3	2	2	1	3	2	2	1	4	6			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr18:21330996A>C	uc002kuq.2	+	5	885	c.799A>C	c.(799-801)ACG>CCG	p.T267P	LAMA3_uc010dlv.1_Missense_Mutation_p.T267P|LAMA3_uc002kur.2_Missense_Mutation_p.T267P	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	267	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAGAACCAATACGCTTCTTGG	0.438													12	83					0	0	0	0	C	21330996	C	C	21330996	3	2	156	1	0	0	0	0	1	0	0	0	8647	391	14	5	817	5	LAMA3	18	21330996	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08		21330996	56746252	140	28957											
DOCK6	57572	broad.mit.edu	37	chr19	11348922	11348922	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactcgcacagcaaggttgcGcacggagccctggcggctgc	7	5	14	15	4	0	0	0	0	0	0	1	1	0	1	1	4	4	5	1	4	1	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr19:11348922G>C	uc002mqs.3	-	15	1743	c.1702C>G	c.(1702-1704)CGC>GGC	p.R568G	DOCK6_uc010xlq.1_5'Flank|LOC55908_uc010dxw.2_Intron|LOC55908_uc010dxx.2_Missense_Mutation_p.R35P	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	568	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GCAAGGTTGCGCACGGAGCCC	0.672													9	38					0	0	0	0	C	11348922	C	C	11348922	3	2	156	1	0	0	0	0	1	0	0	0	4713	1087	38	3	4577	3	DOCK6	19	11348922	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08		11348922	47780061	141	28958											
ZNF43	7594	broad.mit.edu	37	chr19	21992242	21992242	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcacatttgcagaaattCactctggtatgaattatttt	11	19	5	6	0	3	2	2	1	1	1	3	2	3	2	0	1	1	2	0	1	4	8			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr19:21992242C>A	uc002nqj.2	-	4	727	c.597G>T	c.(595-597)GTG>GTT	p.V199V	ZNF43_uc010ecv.2_Silent_p.V193V|ZNF43_uc002nql.2_Silent_p.V193V|ZNF43_uc002nqm.2_Silent_p.V193V|ZNF43_uc002nqk.2_Silent_p.V129V	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TGCAGAAATTCACTCTGGTAT	0.333													9	40					0.000442599	0.00170176	1	0	A	21992242	A	A	21992242	2	1	156	1	0	0	0	0	0	0	0	1	17970	813	29	2		2	ZNF43	19	21992242	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	10643320	21992242	37136741	142	28959											
ZNF536	9745	broad.mit.edu	37	chr19	30936342	30936342	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataacctgcagggtcctgggAacatgaaggagaagcccacc	13	5	12	11	0	0	2	0	1	0	1	1	4	1	3	4	3	4	1	4	3	4	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr19:30936342A>G	uc002nsu.1	+	2	2011	c.1873A>G	c.(1873-1875)AAC>GAC	p.N625D	ZNF536_uc010edd.1_Missense_Mutation_p.N625D	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	625					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGGTCCTGGGAACATGAAGGA	0.587													22	108					0	0	0	0	G	30936342	G	G	30936342	3	3	156	1	0	0	0	0	1	0	0	0	18041	246	9	5	1875	5	ZNF536	19	30936342	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	8944100	30936342	28192641	143	28960											
SIPA1L3	23094	broad.mit.edu	37	chr19	38600875	38600875	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccctttcccagctgctacgGaagaggcacataggaaatga	12	7	11	11	1	0	2	0	1	0	1	1	4	1	4	2	3	3	3	2	3	4	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr19:38600875G>A	uc002ohk.2	+	8	2651	c.2142G>A	c.(2140-2142)CGG>CGA	p.R714R		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	714	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGCTGCTACGGAAGAGGCACA	0.617													12	84					0	0	0	0	A	38600875	A	A	38600875	2	1	156	1	0	0	0	0	0	0	0	1	14396	1161	41	2		2	SIPA1L3	19	38600875	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	7664533	38600875	20528108	144	28961											
PRR12	57479	broad.mit.edu	37	chr19	50098071	50098071	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggcttccttcggcagccGccccttcccagtgccctcgt	2	9	9	21	4	0	0	0	0	0	0	4	0	2	0	7	2	2	2	7	2	0	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr19:50098071G>A	uc002poo.3	+	4	479	c.479G>A	c.(478-480)CGC>CAC	p.R160H		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		TTCGGCAGCCGCCCCTTCCCA	0.662													6	13					0	0	0	0	A	50098071	A	A	50098071	3	1	156	1	0	0	0	0	1	0	0	0	12646	1087	38	1	493	1	PRR12	19	50098071	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	11497196	50098071	9030912	145	28962											
NLRP8	126205	broad.mit.edu	37	chr19	56490773	56490773	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcacaggctggaaaactgcCtgttcacctccatctgctgc	8	10	9	14	0	3	0	2	0	1	0	4	1	4	1	3	2	4	3	3	2	2	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr19:56490773C>T	uc002qmh.2	+	9	2961	c.2890C>T	c.(2890-2892)CTG>TTG	p.L964L	NLRP8_uc010etg.2_Silent_p.L945L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	964						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GGAAAACTGCCTGTTCACCTC	0.517													29	48					0	0	0	0	T	56490773	T	T	56490773	2	4	156	1	0	0	0	0	0	0	0	1	10537	680	24	4		4	NLRP8	19	56490773	Silent	SNP	C	TCGA-CR-7390-01A-11D-2012-08	6392702	56490773	2638210	146	28963											
ZNF667	63934	broad.mit.edu	37	chr19	56953462	56953462	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttctctccagcatgaattCttttatgtacaacaaagact	12	16	4	9	0	2	2	0	1	2	1	4	2	3	2	1	0	3	2	1	0	5	6			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr19:56953462C>A	uc002qnd.2	-	5	1064	c.902G>T	c.(901-903)AGA>ATA	p.R301I	ZNF667_uc010etl.2_Missense_Mutation_p.R83I|ZNF667_uc002qne.2_Missense_Mutation_p.R301I|ZNF667_uc010etm.2_Missense_Mutation_p.R244I	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	301	C2H2-type 5; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		AGCATGAATTCTTTTATGTAC	0.328													14	54					0.000219431	0.000848232	1	0	A	56953462	A	A	56953462	3	1	156	1	0	0	0	0	1	0	0	0	18141	913	32	2	934	2	ZNF667	19	56953462	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	462689	56953462	2175521	147	28964											
ZNF667	63934	broad.mit.edu	37	chr19	56953707	56953707	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctttccatcatgaattctCatatgtagaataagggttgt	11	16	7	7	0	2	2	2	1	1	1	5	2	4	2	2	1	0	2	2	1	5	6	rs140879761		TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr19:56953707C>G	uc002qnd.2	-	5	819	c.657G>C	c.(655-657)ATG>ATC	p.M219I	ZNF667_uc010etl.2_Missense_Mutation_p.M1I|ZNF667_uc002qne.2_Missense_Mutation_p.M219I|ZNF667_uc010etm.2_Missense_Mutation_p.M162I	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	219	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CATGAATTCTCATATGTAGAA	0.373													26	69					0	0	0	0	G	56953707	G	G	56953707	3	3	156	1	0	0	0	0	1	0	0	0	18141	826	29	2	1179	2	ZNF667	19	56953707	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	245	56953707	2175276	148	28965											
IDH3B	3420	broad.mit.edu	37	chr20	2640753	2640753	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaaccaggccagcagccaGattgtcaataatgttcccat	12	8	7	14	0	1	1	1	0	0	1	2	1	2	1	5	1	3	2	5	1	3	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr20:2640753G>A	uc002wgp.2	-	9	847	c.838C>T	c.(838-840)CTG>TTG	p.L280L	IDH3B_uc002wgq.2_Silent_p.L280L|IDH3B_uc002wgr.2_Silent_p.L128L	NM_006899	NP_008830	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3, beta subunit isoform	280					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	CCAGCAGCCAGATTGTCAATA	0.517													18	89					0	0	0	0	A	2640753	A	A	2640753	2	1	156	1	0	0	0	0	0	0	0	1	7536	933	33	2		2	IDH3B	20	2640753	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08		2640753	60384767	149	28966											
SLC4A11	83959	broad.mit.edu	37	chr20	3214600	3214600	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acgactgctggtaccgcaccCctgtcactgtggcggtgacc	6	8	12	15	3	1	1	1	1	0	0	1	2	1	1	4	3	2	3	4	3	1	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr20:3214600C>T	uc002wig.2	-	5	668	c.620G>A	c.(619-621)GGG>GAG	p.G207E	SLC4A11_uc010zqe.1_Missense_Mutation_p.G234E|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.G191E	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	207	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						GTACCGCACCCCTGTCACTGT	0.622													18	81					0	0	0	0	T	3214600	T	T	3214600	3	4	156	1	0	0	0	0	1	0	0	0	14716	623	22	4	2115	4	SLC4A11	20	3214600	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	573847	3214600	59810920	150	28967											
BPIL1	80341	broad.mit.edu	37	chr20	31604856	31604856	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcttaccacagctgtgcctGagcatctccaacctggtgca	8	10	9	14	0	2	1	0	1	2	0	3	1	2	1	4	1	6	3	4	1	2	1	rs142934424	by1000genomes	TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr20:31604856G>C	uc002wyj.2	+	7	719	c.525G>C	c.(523-525)CTG>CTC	p.L175L		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	175						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						AGCTGTGCCTGAGCATCTCCA	0.617													28	112					0	0	0	0	C	31604856	C	C	31604856	2	2	156	1	0	0	0	0	0	0	0	1	1496	1277	45	2		2	BPIL1	20	31604856	Silent	SNP	G	TCGA-CR-7390-01A-11D-2012-08	28390256	31604856	31420664	151	28968											
SON	6651	broad.mit.edu	37	chr21	34923284	34923284	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cttcggcaactagggcactgGagttgtcggggcagcctgtg	6	9	16	10	2	0	0	0	0	0	0	2	1	0	1	1	5	2	4	1	5	2	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr21:34923284G>C	uc002yse.1	+	3	1796	c.1747G>C	c.(1747-1749)GAG>CAG	p.E583Q	SON_uc002ysb.1_Missense_Mutation_p.E583Q|SON_uc002ysc.2_Missense_Mutation_p.E583Q|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	583					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TAGGGCACTGGAGTTGTCGGG	0.667													12	50					0	0	0	0	C	34923284	C	C	34923284	3	2	156	1	0	0	0	0	1	0	0	0	14990	1175	41	2	1757	2	SON	21	34923284	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08		34923284	13206611	152	28969											
C21orf29	54084	broad.mit.edu	37	chr21	45919706	45919706	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaccctggagaggggctccTtggcgctggagtagatgagg	7	7	19	8	1	0	3	0	1	0	2	1	6	1	5	2	7	0	3	2	7	1	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr21:45919706T>A	uc002zfe.1	-	12	2036	c.1970A>T	c.(1969-1971)AAG>ATG	p.K657M	C21orf29_uc010gpv.1_Missense_Mutation_p.K589M	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	657	EAR 7.				cell adhesion	extracellular region	structural molecule activity				0						GAGGGGCTCCTTGGCGCTGGA	0.716													3	6					0	0	0	0	A	45919706	A	A	45919706	3	1	156	1	0	0	0	0	1	0	0	0	2134	1609	56	5	43	5	C21orf29	21	45919706	Missense_Mutation	SNP	T	TCGA-CR-7390-01A-11D-2012-08	10996422	45919706	2210189	153	28970											
CABIN1	23523	broad.mit.edu	37	chr22	24567922	24567922	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgggcctccccggccacAcaggcctgaagctaccccca	7	4	9	21	1	0	1	0	1	0	0	1	1	1	1	8	3	2	1	8	3	2	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr22:24567922A>G	uc002zzi.1	+	34	6126	c.5999A>G	c.(5998-6000)CAC>CGC	p.H2000R	CABIN1_uc002zzj.1_Missense_Mutation_p.H1921R|CABIN1_uc002zzl.1_Missense_Mutation_p.H2000R|CABIN1_uc010gul.1_5'UTR	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	2000					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CCCCGGCCACACAGGCCTGAA	0.657													9	42					0	0	0	0	G	24567922	G	G	24567922	3	3	156	1	0	0	0	0	1	0	0	0	2540	159	6	5	6129	5	CABIN1	22	24567922	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08		24567922	26736644	154	28971											
PIWIL3	440822	broad.mit.edu	37	chr22	25120933	25120933	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcttgaagctgaccatctcCcactccatcccgatacacaa	11	9	5	16	1	1	2	0	2	1	0	4	3	3	2	4	0	3	2	4	0	3	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr22:25120933C>G	uc003abd.1	-	18	2596	c.2179G>C	c.(2179-2181)GGA>CGA	p.G727R	PIWIL3_uc011ajx.1_Missense_Mutation_p.G609R|PIWIL3_uc011ajy.1_Missense_Mutation_p.G609R|PIWIL3_uc010gut.1_Missense_Mutation_p.G718R	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	727	Piwi.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						TGACCATCTCCCACTCCATCC	0.393													10	32					0	0	0	0	G	25120933	G	G	25120933	3	3	156	1	0	0	0	0	1	0	0	0	12014	632	22	4	485	4	PIWIL3	22	25120933	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	553011	25120933	26183633	155	28972											
YWHAH	7533	broad.mit.edu	37	chr22	32352249	32352249	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcattgagcagaaaaccAtggctgatggaaacgaaaag	17	5	12	7	1	0	3	0	2	0	1	0	5	0	4	1	2	4	4	1	2	5	1			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr22:32352249A>G	uc003alz.2	+	2	452	c.211A>G	c.(211-213)ATG>GTG	p.M71V	YWHAH_uc010gwl.2_Missense_Mutation_p.M1V|YWHAH_uc003ama.2_Missense_Mutation_p.M1V|YWHAH_uc010gwm.2_Missense_Mutation_p.M58V	NM_003405	NP_003396	Q04917	1433F_HUMAN	tyrosine 3-monooxygenase/tryptophan	71					glucocorticoid catabolic process|glucocorticoid receptor signaling pathway|intracellular protein transport|negative regulation of dendrite morphogenesis|positive regulation of transcription, DNA-dependent|regulation of synaptic plasticity	cytoplasm	enzyme binding|glucocorticoid receptor binding|insulin-like growth factor receptor binding|protein domain specific binding			central_nervous_system(1)	1						GCAGAAAACCATGGCTGATGG	0.468													12	70					0	0	0	0	G	32352249	G	G	32352249	3	3	156	1	0	0	0	0	1	0	0	0	17572	217	8	5	217	5	YWHAH	22	32352249	Missense_Mutation	SNP	A	TCGA-CR-7390-01A-11D-2012-08	7231316	32352249	18952317	156	28973											
FAM116B	414918	broad.mit.edu	37	chr22	50752289	50752289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcgcggtggaggtgggccGtgtaagcggtgtagaggcct	5	9	20	7	4	0	1	0	0	0	1	1	2	0	2	2	6	1	2	2	6	2	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chr22:50752289G>A	uc011aru.1	-	15	1229	c.1157C>T	c.(1156-1158)ACG>ATG	p.T386M	FAM116B_uc011arv.1_Missense_Mutation_p.T386M	NM_001001794	NP_001001794	Q8NEG7	F116B_HUMAN	family with sequence similarity 116, member B	386											0		all_cancers(38;4.34e-09)|all_epithelial(38;3.03e-08)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GAGGTGGGCCGTGTAAGCGGT	0.672													9	21					0	0	0	0	A	50752289	A	A	50752289	3	1	156	1	0	0	0	0	1	0	0	0	5436	1145	40	1	628	1	FAM116B	22	50752289	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	18400040	50752289	552277	157	28974											
TLR8	51311	broad.mit.edu	37	chrX	12938009	12938009	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatagatcgttttgcttttCaaaacttgacccaacttcga	12	15	5	9	2	1	2	1	1	0	1	3	3	1	2	1	0	3	2	1	0	5	8			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chrX:12938009C>G	uc004cve.2	+	2	918	c.850C>G	c.(850-852)CAA>GAA	p.Q284E	TLR8_uc004cvd.2_Missense_Mutation_p.Q302E	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	284	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TTTTGCTTTTCAAAACTTGAC	0.438													14	19					0	0	0	0	G	12938009	G	G	12938009	3	3	156	1	0	0	0	0	1	0	0	0	16023	827	29	2	856	2	TLR8	23	12938009	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08		12938009	142332551	158	28975											
PPEF1	5475	broad.mit.edu	37	chrX	18748392	18748392	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgccctcaccatcttccagtCcatcgaatatgctgatgaac	10	11	6	14	1	2	2	1	2	1	0	5	3	4	2	4	0	3	1	4	0	3	2			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chrX:18748392C>G	uc004cyq.2	+	5	621	c.140C>G	c.(139-141)TCC>TGC	p.S47C	PPEF1_uc004cyp.2_Missense_Mutation_p.S47C|PPEF1_uc004cyr.2_Missense_Mutation_p.S47C|PPEF1_uc004cys.2_Missense_Mutation_p.S47C|PPEF1_uc011mja.1_Intron|PPEF1_uc011mjb.1_5'UTR	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	47					detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					ATCTTCCAGTCCATCGAATAT	0.443													18	28					0	0	0	0	G	18748392	G	G	18748392	3	3	156	1	0	0	0	0	1	0	0	0	12362	855	30	2	146	2	PPEF1	23	18748392	Missense_Mutation	SNP	C	TCGA-CR-7390-01A-11D-2012-08	5810383	18748392	136522168	159	28976											
WNK3	65267	broad.mit.edu	37	chrX	54259359	54259359	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaaggaatctcagtagattGggttttgctatctttaattg	11	16	9	5	0	2	1	1	0	2	1	3	2	2	2	0	2	1	3	0	2	5	8			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chrX:54259359G>T	uc004dtd.1	-	21	5021	c.4582C>A	c.(4582-4584)CAA>AAA	p.Q1528K	WNK3_uc004dtc.1_Missense_Mutation_p.Q1575K	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1528					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity	p.Q1575*(1)		lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TCAGTAGATTGGGTTTTGCTA	0.468													18	28					8.10497e-08	3.27386e-07	1	0	T	54259359	T	T	54259359	3	4	156	1	0	0	0	0	1	0	0	0	17447	1357	47	4	695	4	WNK3	23	54259359	Missense_Mutation	SNP	G	TCGA-CR-7390-01A-11D-2012-08	35510967	54259359	101011201	160	28977											
MAGEA12	4111	broad.mit.edu	37	chrX	151896231	151896231	+	RNA	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctggtcggagtggctggAtagtgttggcccactccatt	5	12	15	9	1	0	0	0	0	0	0	2	2	1	2	2	6	0	3	2	6	1	3			TCGA-CR-7390-01A-11D-2012-08	TCGA-CR-7390-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	714399af-e425-43bb-a82a-b62ca6fd735d	896b3fbe-2eea-4dd2-b606-29094614f47c	g.chrX:151896231A>G	uc004fgb.2	-	4		c.536T>C						P43365	MAGAC_HUMAN	Homo sapiens melanoma antigen family A, 12, mRNA (cDNA clone MGC:4914 IMAGE:3450217), complete cds.											skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTGGCTGGATAGTGTTGGC	0.517													7	39					0	0	0	0	G	151896231	G	G	151896231	1	3	156	0	1	0	0	0	0	0	0	0	9217	348	12	5		5	MAGEA12	23	151896231	RNA	SNP	A	TCGA-CR-7390-01A-11D-2012-08	97636872	151896231	3374329	161	28978											
NBPF9	400818	broad.mit.edu	37	chr1	144823878	144823878	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggactcactgtatagatgttAttcaactccttcaggttgtc	9	15	8	9	0	3	1	3	0	0	1	5	2	4	2	1	2	1	3	1	2	4	6			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr1:144823878A>C	uc009wig.1	+	17	1995	c.1919A>C	c.(1918-1920)TAT>TCT	p.Y640S	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.Y441S|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Missense_Mutation_p.Y300S	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	640	NBPF 4.					cytoplasm					0						TATAGATGTTATTCAACTCCT	0.483													3	75					0	0	0	0	C	144823878	C	C	144823878	3	2	157	1	0	0	0	0	1	0	0	0	10253	449	16	5	1971	5	NBPF9	1	144823878	Missense_Mutation	SNP	A	TCGA-CR-7391-01A-11D-2012-08		144823878	104426743	1	28979											
OR14I1	401994	broad.mit.edu	37	chr1	248844912	248844912	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtggagaaggcttttgctcGactctgtcctgaagggattc	7	12	14	8	1	1	2	0	1	1	1	4	5	2	3	1	4	1	2	1	4	2	3			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr1:248844912G>A	uc001ieu.1	-	1	694	c.694C>T	c.(694-696)CGA>TGA	p.R232*		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTTTTGCTCGACTCTGTCCT	0.493													5	78					0	0	0	0	A	248844912	A	A	248844912	4	1	157	1	0	0	0	0	0	1	0	0	11001	1066	37	1	245	1	OR14I1	1	248844912	Nonsense_Mutation	SNP	G	TCGA-CR-7391-01A-11D-2012-08	104021034	248844912	405709	2	28980											
RANBP2	5903	broad.mit.edu	37	chr2	109352601	109352601	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttggagtctgataaaagTgactggcgagcaaccaatac	13	10	11	7	1	1	2	0	2	1	0	1	4	1	3	1	2	3	2	1	2	5	3			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr2:109352601T>C	uc002tem.3	+	6	804	c.678T>C	c.(676-678)AGT>AGC	p.S226S		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	226					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CTGATAAAAGTGACTGGCGAG	0.368													7	269					0	0	0	0	C	109352601	C	C	109352601	2	2	157	1	0	0	0	0	0	0	0	1	13093	1693	59	5		5	RANBP2	2	109352601	Silent	SNP	T	TCGA-CR-7391-01A-11D-2012-08		109352601	133846772	3	28981											
ECE2	9718	broad.mit.edu	37	chr3	184009925	184009925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacagccctgcccgcttcCgcgtgctgggcactctctcc	3	8	9	21	3	1	0	0	0	1	0	4	0	3	0	5	1	3	3	5	1	0	1			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr3:184009925C>T	uc003fni.3	+	19	2589	c.2551C>T	c.(2551-2553)CGC>TGC	p.R851C	ECE2_uc003fnl.3_Missense_Mutation_p.R779C|ECE2_uc003fnm.3_Missense_Mutation_p.R733C|ECE2_uc003fnk.3_Missense_Mutation_p.R704C	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	851	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCCCGCTTCCGCGTGCTGGG	0.677													8	61					0	0	0	0	T	184009925	T	T	184009925	3	4	157	1	0	0	0	0	1	0	0	0	4912	652	23	1	3189	1	ECE2	3	184009925	Missense_Mutation	SNP	C	TCGA-CR-7391-01A-11D-2012-08		184009925	14012505	4	28982											
C8orf58	541565	broad.mit.edu	37	chr8	22459568	22459570	+	In_Frame_Del	DEL	GCT	-	-																															cgggggcaggggccatgggaGctgctaagccagacagagca																										TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr8:22459568_22459570delGCT	uc003xce.2	+	4	853_855	c.741_743delGCT	c.(739-744)GAGCTG>GAG	p.L249del	C8orf58_uc011kzl.1_In_Frame_Del_p.L249del|C8orf58_uc003xcf.2_In_Frame_Del_p.L249del|KIAA1967_uc003xch.2_5'Flank|KIAA1967_uc003xci.2_5'Flank	NM_001013842	NP_001013864	Q8NAV2	CH058_HUMAN	hypothetical protein LOC541565	249										skin(1)	1		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GGCCATGGGAGCTGCTAAGCCAG	0.64													---	---	---								-	22459570	-	-	22459568	7	5	157	1	0	1	0	1	0	0	0	0	2445	962	34	0	755	0	C8orf58	8	22459568	In_Frame_Del	DEL	GCT	TCGA-CR-7391-01A-11D-2012-08		22459568	123904454	5	28983											
TEX15	56154	broad.mit.edu	37	chr8	30701885	30701885	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtcaagtcagactgcgagTctttactaactttaatttcc	11	15	6	9	1	3	1	2	0	1	1	4	2	4	1	1	0	3	0	1	0	4	6			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr8:30701885T>A	uc003xil.2	-	1	4649	c.4649A>T	c.(4648-4650)GAC>GTC	p.D1550V		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1550										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGACTGCGAGTCTTTACTAAC	0.383													8	126					0	0	0	0	A	30701885	A	A	30701885	3	1	157	1	0	0	0	0	1	0	0	0	15845	1667	58	5	3736	5	TEX15	8	30701885	Missense_Mutation	SNP	T	TCGA-CR-7391-01A-11D-2012-08	8242317	30701885	115662137	6	28984											
EPPK1	83481	broad.mit.edu	37	chr8	144946714	144946714	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaccgccccgcccatggaGcggaaggtgatcttgagggg	7	6	15	13	3	2	2	1	2	1	0	2	4	2	4	4	5	1	0	4	5	1	1			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr8:144946714G>A	uc003zaa.1	-	1	721	c.708C>T	c.(706-708)CGC>CGT	p.R236R		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	236						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGCCCATGGAGCGGAAGGTGA	0.682													3	15					0	0	0	0	A	144946714	A	A	144946714	2	1	157	1	0	0	0	0	0	0	0	1	5214	958	34	4		4	EPPK1	8	144946714	Silent	SNP	G	TCGA-CR-7391-01A-11D-2012-08	114244829	144946714	1417308	7	28985											
ANK3	288	broad.mit.edu	37	chr10	61835630	61835630	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actttaaaggtgaagatattAgcggtgctgctgatgtaata	13	13	11	4	1	0	3	0	2	0	1	0	3	0	3	0	2	3	3	0	2	7	6			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr10:61835630A>G	uc001jky.2	-	37	5201	c.5009T>C	c.(5008-5010)CTA>CCA	p.L1670P	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1670	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TGAAGATATTAGCGGTGCTGC	0.388													3	84					0	0	0	0	G	61835630	G	G	61835630	3	3	157	1	0	0	0	0	1	0	0	0	622	420	15	5	8465	5	ANK3	10	61835630	Missense_Mutation	SNP	A	TCGA-CR-7391-01A-11D-2012-08		61835630	73699117	8	28986											
SERPING1	710	broad.mit.edu	37	chr11	57382046	57382046	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggcgagtatatgaccccAgggcctgagacctgcaggat	9	7	15	10	1	0	2	0	2	0	1	0	5	0	3	4	4	1	2	4	4	2	2			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr11:57382046A>G	uc001nkp.1	+	8	1686	c.1495A>G	c.(1495-1497)AGG>GGG	p.R499G	SERPING1_uc001nkq.1_Missense_Mutation_p.R462G|SERPING1_uc010rju.1_Missense_Mutation_p.R447G|SERPING1_uc010rjv.1_Missense_Mutation_p.R504G|SERPING1_uc001nkr.1_Missense_Mutation_p.R499G|SERPING1_uc009ymi.1_Missense_Mutation_p.R508G|SERPING1_uc009ymj.1_3'UTR|SERPING1_uc001nks.1_Missense_Mutation_p.R190G	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	499					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						ATATGACCCCAGGGCCTGAGA	0.622									Hereditary_Angioedema				3	31					0	0	0	0	G	57382046	G	G	57382046	3	3	157	1	0	0	0	0	1	0	0	0	14181	179	7	5	1521	5	SERPING1	11	57382046	Missense_Mutation	SNP	A	TCGA-CR-7391-01A-11D-2012-08		57382046	77624470	9	28987											
GPR109B	8843	broad.mit.edu	37	chr12	123200861	123200861	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagatgatggctgctgtccAattggagatcttgttcaggg	9	12	14	6	0	2	3	1	1	1	2	3	5	3	3	1	3	1	3	1	3	1	3			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr12:123200861A>G	uc001ucy.3	-	1	579	c.424T>C	c.(424-426)TGG>CGG	p.W142R	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	142	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	GCTGCTGTCCAATTGGAGATC	0.542													3	77					0	0	0	0	G	123200861	G	G	123200861	3	3	157	1	0	0	0	0	1	0	0	0	6664	130	5	5	743	5	GPR109B	12	123200861	Missense_Mutation	SNP	A	TCGA-CR-7391-01A-11D-2012-08		123200861	10651034	10	28988											
ATAD5	79915	broad.mit.edu	37	chr17	29162940	29162940	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccattagaggtattgattCtgacgatgtacaagataata	16	12	8	5	1	1	4	0	2	1	2	1	5	1	4	1	1	2	2	1	1	7	7			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr17:29162940C>G	uc002hfs.1	+	2	2187	c.1841C>G	c.(1840-1842)TCT>TGT	p.S614C	ATAD5_uc002hft.1_Missense_Mutation_p.S511C	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	614					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GGTATTGATTCTGACGATGTA	0.393													6	64					0	0	0	0	G	29162940	G	G	29162940	3	3	157	1	0	0	0	0	1	0	0	0	1078	913	32	2	1847	2	ATAD5	17	29162940	Missense_Mutation	SNP	C	TCGA-CR-7391-01A-11D-2012-08		29162940	52032270	11	28989											
PTPRT	11122	broad.mit.edu	37	chr20	40727119	40727119	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagttgtaatcgaacaccAgcctccagaagtctgccacg	12	7	9	13	2	1	1	0	0	1	1	3	2	2	1	4	0	4	3	4	0	3	2			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chr20:40727119A>G	uc002xkg.2	-	27	3972	c.3788T>C	c.(3787-3789)CTG>CCG	p.L1263P	PTPRT_uc010ggj.2_Missense_Mutation_p.L1282P|PTPRT_uc010ggi.2_Missense_Mutation_p.L466P	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1263	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.K1263K(1)		skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATCGAACACCAGCCTCCAGAA	0.592													3	67					0	0	0	0	G	40727119	G	G	40727119	3	3	157	1	0	0	0	0	1	0	0	0	12877	188	7	5	557	5	PTPRT	20	40727119	Missense_Mutation	SNP	A	TCGA-CR-7391-01A-11D-2012-08		40727119	22298401	12	28990											
MORC4	79710	broad.mit.edu	37	chrX	106186359	106186359	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaggcatggaataatctaGagaaggtgttgtcatctcat	13	11	11	6	0	3	1	2	0	2	1	4	3	3	2	0	3	1	3	0	3	4	3			TCGA-CR-7391-01A-11D-2012-08	TCGA-CR-7391-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	7236609c-34dd-425a-b882-2dff36983f7b	d00e373a-4fb4-42e6-b71e-a61bad73e27e	g.chrX:106186359G>C	uc004emu.3	-	15	2005	c.1762C>G	c.(1762-1764)CTA>GTA	p.L588V	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Missense_Mutation_p.L588V|MORC4_uc004emw.3_Missense_Mutation_p.L336V	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	588							ATP binding|zinc ion binding			ovary(1)	1						GAATAATCTAGAGAAGGTGTT	0.453													8	154					0	0	0	0	C	106186359	C	C	106186359	3	2	157	1	0	0	0	0	1	0	0	0	9757	933	33	2	1063	2	MORC4	23	106186359	Missense_Mutation	SNP	G	TCGA-CR-7391-01A-11D-2012-08		106186359	49084201	13	28991											
LRIG2	9860	broad.mit.edu	37	chr1	113616160	113616160	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccggagcaggtctctgcccCgcgccctgctcctgccgcat	3	7	12	19	4	1	0	0	0	1	0	3	1	2	1	6	2	4	3	6	2	0	0			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr1:113616160C>G	uc001edf.1	+	1	330	c.132C>G	c.(130-132)CCC>CCG	p.P44P	LRIG2_uc009wgn.1_5'UTR|uc001ede.1_5'Flank	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	44	LRRNT.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		GTCTCTGCCCCGCGCCCTGCT	0.657											OREG0013684	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	206					0	0	0	0	G	113616160	G	G	113616160	2	3	158	1	0	0	0	0	0	0	0	1	8995	639	23	3		3	LRIG2	1	113616160	Silent	SNP	C	TCGA-CR-7392-01A-11D-2012-08		113616160	135634461	1	28992											
IL6R	3570	broad.mit.edu	37	chr1	154407116	154407116	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacatagtgtccatgtgcGtcgccagtagtgtcgggagc	7	11	13	10	3	1	0	0	0	1	0	4	1	2	1	2	1	3	1	2	1	3	3			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr1:154407116G>A	uc001fez.1	+	4	1017	c.580G>A	c.(580-582)GTC>ATC	p.V194I	IL6R_uc001ffa.1_Missense_Mutation_p.V194I	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	194	Extracellular (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity	p.V194I(1)		ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GTCCATGTGCGTCGCCAGTAG	0.532													6	159					0	0	0	0	A	154407116	A	A	154407116	3	1	158	1	0	0	0	0	1	0	0	0	7741	1145	40	1	594	1	IL6R	1	154407116	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08	40790956	154407116	94843505	2	28993											
DCAF6	55827	broad.mit.edu	37	chr1	167906205	167906205	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacgtgaggaaaaggtcccTcgggctggaggacccgtccc	8	5	16	12	3	0	1	0	1	0	0	3	5	2	5	3	6	0	1	3	6	2	0			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr1:167906205T>C	uc001gew.2	+	1	298	c.56T>C	c.(55-57)CTC>CCC	p.L19P	BRP44_uc001ges.2_5'Flank|BRP44_uc001get.2_5'UTR|BRP44_uc001geu.2_Intron|BRP44_uc009wvn.2_5'Flank|DCAF6_uc001gev.2_Missense_Mutation_p.L19P|DCAF6_uc001gex.2_Missense_Mutation_p.L19P|DCAF6_uc010plk.1_Missense_Mutation_p.L19P	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	19					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AAAAGGTCCCTCGGGCTGGAG	0.721													3	23					0	0	0	0	C	167906205	C	C	167906205	3	2	158	1	0	0	0	0	1	0	0	0	4291	1551	54	5	58	5	DCAF6	1	167906205	Missense_Mutation	SNP	T	TCGA-CR-7392-01A-11D-2012-08	13499089	167906205	81344416	3	28994											
ZNF238	10472	broad.mit.edu	37	chr1	244217659	244217659	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcctgggaacatgtggatgCgattgccctcagactcagca	10	8	12	11	1	2	1	2	0	0	1	2	4	2	3	2	2	5	1	2	2	1	1			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr1:244217659C>T	uc001iae.2	+	1	1078	c.556C>T	c.(556-558)CGA>TGA	p.R186*	ZNF238_uc001iad.3_Nonsense_Mutation_p.R195*|ZNF238_uc001iaf.1_Nonsense_Mutation_p.R186*	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	186				KLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHAT AAGKTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSS LSGVENLNSSYFSSQ -> IEHPAQQKGLGGRAWEHVDAIA LRLSRHPPGWRRGRATRHSSWKNSSQPLQLNRVFVPE (in Ref. 1; AAA81368).	negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			CATGTGGATGCGATTGCCCTC	0.572													7	74					0	0	0	0	T	244217659	T	T	244217659	4	4	158	1	0	0	0	0	0	1	0	0	17857	760	27	1	589	1	ZNF238	1	244217659	Nonsense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08	76311454	244217659	5032962	4	28995											
DOK1	1796	broad.mit.edu	37	chr2	74783609	74783609	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagagctgactcccatgaaGgggaggtggcagaggggaag	11	5	18	7	0	1	4	1	2	0	2	2	6	2	6	1	6	1	2	1	6	2	0			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr2:74783609G>C	uc002sms.2	+	5	836	c.814G>C	c.(814-816)GGG>CGG	p.G272R	LOXL3_uc002smp.1_5'Flank|LOXL3_uc002smq.1_5'Flank|LOXL3_uc010ffn.1_5'Flank|DOK1_uc002smr.2_Missense_Mutation_p.G133R|DOK1_uc010ffo.2_Missense_Mutation_p.G133R|DOK1_uc002smt.2_Missense_Mutation_p.G58R|DOK1_uc002smu.2_Missense_Mutation_p.G58R|DOK1_uc010yrz.1_Missense_Mutation_p.G261R|DOK1_uc002smv.2_Missense_Mutation_p.G133R|DOK1_uc002smw.1_Missense_Mutation_p.G58R	NM_001381	NP_001372	Q99704	DOK1_HUMAN	docking protein 1	272					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding				0						CTCCCATGAAGGGGAGGTGGC	0.612													4	91					0	0	0	0	C	74783609	C	C	74783609	3	2	158	1	0	0	0	0	1	0	0	0	4718	1000	35	4	832	4	DOK1	2	74783609	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08		74783609	168415764	5	28996											
CCDC80	151887	broad.mit.edu	37	chr3	112324348	112324348	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tatccttggtggtaactatgGtaaccatagcctgcatactc	10	13	8	10	0	0	0	0	0	0	0	2	0	1	0	3	3	5	3	3	3	6	7			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr3:112324348G>A	uc003dzf.2	-	8	2987	c.2769C>T	c.(2767-2769)TAC>TAT	p.Y923Y	CCDC80_uc011bhv.1_Silent_p.Y896Y|CCDC80_uc003dzg.2_Silent_p.Y923Y	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	923										ovary(2)	2						GGTAACTATGGTAACCATAGC	0.463													4	83					0	0	0	0	A	112324348	A	A	112324348	2	1	158	1	0	0	0	0	0	0	0	1	2867	1256	44	4		4	CCDC80	3	112324348	Silent	SNP	G	TCGA-CR-7392-01A-11D-2012-08		112324348	85698082	6	28997											
SOX2	6657	broad.mit.edu	37	chr3	181430843	181430843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcctactcgcagcagggcaCccctggcatggctcttggct	5	9	12	15	1	1	0	0	0	1	0	3	0	2	0	3	4	2	6	3	4	1	2			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr3:181430843C>T	uc003fkx.2	+	1	1122	c.695C>T	c.(694-696)ACC>ATC	p.T232I	SOX2OT_uc003fkv.2_Intron|SOX2OT_uc003fkw.3_Intron	NM_003106	NP_003097	P48431	SOX2_HUMAN	sex-determining region Y-box 2	232					cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			CAGCAGGGCACCCCTGGCATG	0.642			A		NSCLC|oesophageal squamous carcinoma		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						7	71					0	0	0	0	T	181430843	T	T	181430843	3	4	158	1	0	0	0	0	1	0	0	0	15013	507	18	4	697	4	SOX2	3	181430843	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08	69106495	181430843	16591587	7	28998											
GAK	2580	broad.mit.edu	37	chr4	861163	861163	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgtctctgtcctccatcaggGcagactcgctctccttggaa	6	11	9	15	2	3	1	1	0	2	1	8	2	5	2	3	2	0	2	3	2	1	1			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr4:861163G>C	uc003gbm.3	-	21	2652	c.2453C>G	c.(2452-2454)GCC>GGC	p.A818G	GAK_uc003gbn.3_Missense_Mutation_p.A739G|GAK_uc010ibk.1_Missense_Mutation_p.A712G|GAK_uc010ibi.2_5'UTR|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.A682G	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	818					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		CTCCATCAGGGCAGACTCGCT	0.597													5	128					0	0	0	0	C	861163	C	C	861163	3	2	158	1	0	0	0	0	1	0	0	0	6230	1203	42	4	1514	4	GAK	4	861163	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08		861163	190293113	8	28999											
CAMK2D	817	broad.mit.edu	37	chr4	114680566	114680566	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcttctcaccactgagaatgCccccctggaaaccaataatt	12	10	5	14	0	2	1	1	1	2	1	3	3	2	2	5	1	2	0	5	1	4	3			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr4:114680566C>T	uc003ibi.2	-	2	929	c.70G>A	c.(70-72)GCA>ACA	p.A24T	CAMK2D_uc003ibj.2_Missense_Mutation_p.A24T|CAMK2D_uc003ibk.2_Missense_Mutation_p.A24T|CAMK2D_uc003ibo.3_Missense_Mutation_p.A24T|CAMK2D_uc003ibm.2_Missense_Mutation_p.A24T|CAMK2D_uc003ibn.2_Missense_Mutation_p.A24T|CAMK2D_uc003ibl.2_Missense_Mutation_p.A24T	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	24	ATP (By similarity).|Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		ACTGAGAATGCCCCCCTGGAA	0.318													4	87					0	0	0	0	T	114680566	T	T	114680566	3	4	158	1	0	0	0	0	1	0	0	0	2613	739	26	4	1592	4	CAMK2D	4	114680566	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08	113819403	114680566	76473710	9	29000											
KIAA1109	84162	broad.mit.edu	37	chr4	123147970	123147970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatgtcagcatggaattgatCgtcggttctgtgaatccaag	10	13	11	7	2	2	2	1	2	1	0	5	3	3	3	1	2	1	2	1	2	4	3			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr4:123147970C>T	uc003ieh.2	+	22	2947	c.2902C>T	c.(2902-2904)CGT>TGT	p.R968C	KIAA1109_uc003iei.1_Missense_Mutation_p.R721C|KIAA1109_uc010ins.1_Missense_Mutation_p.R311C|KIAA1109_uc003iej.1_3'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	968					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TGGAATTGATCGTCGGTTCTG	0.338													5	74					0	0	0	0	T	123147970	T	T	123147970	3	4	158	1	0	0	0	0	1	0	0	0	8247	884	31	1	2988	1	KIAA1109	4	123147970	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08	8467404	123147970	68006306	10	29001											
C6	729	broad.mit.edu	37	chr5	41159281	41159281	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggattattgcattctcGggttctcgatctcttataag	8	15	10	8	2	3	0	0	0	3	0	6	2	3	1	0	3	1	3	0	3	3	6			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr5:41159281G>A	uc003jmk.2	-	12	1969	c.1759C>T	c.(1759-1761)CGA>TGA	p.R587*	C6_uc003jml.1_Nonsense_Mutation_p.R587*	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	587	TSP type-1 3.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTGCATTCTCGGGTTCTCGAT	0.493													5	105					0	0	0	0	A	41159281	A	A	41159281	4	1	158	1	0	0	0	0	0	1	0	0	2325	1124	39	1	1073	1	C6	5	41159281	Nonsense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08		41159281	139755979	11	29002											
HIST1H1C	3006	broad.mit.edu	37	chr6	26056369	26056369	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccagaagcaccggtgcctttCgtttgcaccagagtgccctt	7	10	10	14	2	0	2	0	0	0	2	1	2	0	2	5	1	4	3	5	1	1	3			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr6:26056369C>G	uc003nfw.2	-	1	331	c.288G>C	c.(286-288)ACG>ACC	p.T96T		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	96	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						CGGTGCCTTTCGTTTGCACCA	0.532													6	178					0	0	0	0	G	26056369	G	G	26056369	2	3	158	1	0	0	0	0	0	0	0	1	7163	871	31	3		3	HIST1H1C	6	26056369	Silent	SNP	C	TCGA-CR-7392-01A-11D-2012-08		26056369	145058698	12	29003											
BAT2	7916	broad.mit.edu	37	chr6	31604566	31604566	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaactttggctccctgccGccagcaccacctcctgcccc	5	8	8	20	1	0	1	0	1	0	0	2	1	2	1	8	1	4	2	8	1	1	1			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr6:31604566G>A	uc003nvb.3	+	28	6240	c.5991G>A	c.(5989-5991)CCG>CCA	p.P1997P	BAT2_uc003nvc.3_Silent_p.P1997P	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1997	3-2.|3 X 50 AA type C repeats.					cytoplasm|nucleus	protein binding				0						GCTCCCTGCCGCCAGCACCAC	0.612													8	282					0	0	0	0	A	31604566	A	A	31604566	2	1	158	1	0	0	0	0	0	0	0	1	1321	1074	38	1		1	BAT2	6	31604566	Silent	SNP	G	TCGA-CR-7392-01A-11D-2012-08	5548197	31604566	139510501	13	29004											
GPR6	2830	broad.mit.edu	37	chr6	110300574	110300574	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgtgtcggggacagtgatcGctggagaaaacgcgctggtg	8	7	18	8	5	0	2	0	1	0	1	2	4	0	3	0	4	1	2	0	4	2	0			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr6:110300574G>A	uc011eaw.1	+	2	439	c.259G>A	c.(259-261)GCT>ACT	p.A87T	GPR6_uc011eav.1_Missense_Mutation_p.A102T|GPR6_uc003ptu.2_Missense_Mutation_p.A87T	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	87	Helical; Name=1; (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		GACAGTGATCGCTGGAGAAAA	0.672													7	157					0	0	0	0	A	110300574	A	A	110300574	3	1	158	1	0	0	0	0	1	0	0	0	6739	1087	38	1	261	1	GPR6	6	110300574	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08	78696008	110300574	60814493	14	29005											
LPA	4018	broad.mit.edu	37	chr6	160952810	160952810	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtaacaaaccttgaaacaCgagcatagacaccaggctta	18	6	7	10	1	0	2	0	1	0	1	0	3	0	2	2	1	4	3	2	1	6	4			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr6:160952810C>A	uc003qtl.2	-	40	6194	c.6074G>T	c.(6073-6075)CGT>CTT	p.R2025L		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4533	Peptidase S1.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CCTTGAAACACGAGCATAGAC	0.458													6	82					4.096e-09	1.48703e-08	1	0	A	160952810	A	A	160952810	3	1	158	1	0	0	0	0	1	0	0	0	8953	536	19	3	52	3	LPA	6	160952810	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08	50652236	160952810	10162257	15	29006											
SUN1	23353	broad.mit.edu	37	chr7	891656	891656	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtttgttactttgatttcttGgctgaatgtgtttcttctta	5	23	8	5	0	3	2	0	2	3	0	3	2	3	2	0	1	1	4	0	1	3	8			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr7:891656G>A	uc011jvp.1	+	8	906	c.827G>A	c.(826-828)TGG>TAG	p.W276*	GET4_uc003sjj.1_RNA|SUN1_uc003sjf.2_Nonsense_Mutation_p.W193*|SUN1_uc011jvq.1_Nonsense_Mutation_p.W174*|SUN1_uc003sjg.2_Nonsense_Mutation_p.W181*|SUN1_uc011jvr.1_Nonsense_Mutation_p.W85*|SUN1_uc003sji.2_Nonsense_Mutation_p.W114*|SUN1_uc003sjk.2_5'Flank	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	303	Nuclear.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						TTGATTTCTTGGCTGAATGTG	0.433													4	111					0	0	0	0	A	891656	A	A	891656	4	1	158	1	0	0	0	0	0	1	0	0	15457	1357	47	4	1036	4	SUN1	7	891656	Nonsense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08		891656	158247007	16	29007											
MAFK	7975	broad.mit.edu	37	chr7	1579888	1579888	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtacgaggcgctgcagacCttcgcgcgcaccgtggcccg	7	5	14	15	7	0	1	0	0	0	1	1	2	0	1	3	2	2	4	3	2	2	2			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr7:1579888C>T	uc003skr.2	+	3	559	c.348C>T	c.(346-348)ACC>ACT	p.T116T	MAFK_uc003sks.1_RNA	NM_002360	NP_002351	O60675	MAFK_HUMAN	v-maf musculoaponeurotic fibrosarcoma oncogene	116					blood coagulation	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.75e-15)		CGCTGCAGACCTTCGCGCGCA	0.682													5	29					0	0	0	0	T	1579888	T	T	1579888	2	4	158	1	0	0	0	0	0	0	0	1	9212	668	24	4		4	MAFK	7	1579888	Silent	SNP	C	TCGA-CR-7392-01A-11D-2012-08	688232	1579888	157558775	17	29008											
SGCE	8910	broad.mit.edu	37	chr7	94230126	94230126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtaaaatcccctctccaCgaatcacttcctgataggtg	11	10	7	13	1	2	1	1	1	1	0	5	2	4	1	4	2	0	1	4	2	4	3			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr7:94230126C>T	uc003unl.2	-	7	980	c.869G>A	c.(868-870)CGT>CAT	p.R290H	SGCE_uc003unk.2_Missense_Mutation_p.R122H|SGCE_uc003unm.2_Missense_Mutation_p.R290H|SGCE_uc003unn.2_Missense_Mutation_p.R290H|SGCE_uc011kic.1_Missense_Mutation_p.R249H|SGCE_uc011kid.1_Missense_Mutation_p.R326H	NM_003919	NP_003910	O43556	SGCE_HUMAN	sarcoglycan, epsilon isoform 2	290	Cys-rich.|Extracellular (Potential).				cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CCCCTCTCCACGAATCACTTC	0.378													9	39					0	0	0	0	T	94230126	T	T	94230126	3	4	158	1	0	0	0	0	1	0	0	0	14267	536	19	1	616	1	SGCE	7	94230126	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08	92650238	94230126	64908537	18	29009											
SDCBP	6386	broad.mit.edu	37	chr8	59492228	59492228	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ataaggatagcactggacatGttggttttatctttaaaaat	14	15	8	4	0	1	0	0	0	1	0	1	2	1	2	0	3	1	3	0	3	6	7			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr8:59492228G>A	uc003xtn.2	+	7	775	c.625G>A	c.(625-627)GTT>ATT	p.V209I	SDCBP_uc003xto.2_Missense_Mutation_p.V208I|SDCBP_uc003xtr.2_Missense_Mutation_p.V208I|SDCBP_uc003xtp.2_Missense_Mutation_p.V203I|SDCBP_uc003xtq.2_Missense_Mutation_p.V209I|SDCBP_uc003xts.2_Missense_Mutation_p.V215I|SDCBP_uc011led.1_Missense_Mutation_p.V150I	NM_005625	NP_005616	O00560	SDCB1_HUMAN	syntenin isoform 1	209	PDZ 2.				actin cytoskeleton organization|axon guidance|positive regulation of phosphorylation|protein targeting to membrane|substrate-dependent cell migration, cell extension|synaptic transmission	cytoskeleton|cytosol|endoplasmic reticulum membrane|focal adhesion|interleukin-5 receptor complex|melanosome|nucleus	cytoskeletal adaptor activity|frizzled binding|interleukin-5 receptor binding|protein heterodimerization activity|protein N-terminus binding|syndecan binding				0		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				CACTGGACATGTTGGTTTTAT	0.338													5	72					0	0	0	0	A	59492228	A	A	59492228	3	1	158	1	0	0	0	0	1	0	0	0	14020	1377	48	4	647	4	SDCBP	8	59492228	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08		59492228	86871794	19	29010											
CA8	767	broad.mit.edu	37	chr8	61135309	61135309	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcatacacccagtaatcccGcagcagagggtctgcacagc	11	7	9	14	1	2	1	1	0	1	1	3	1	3	1	2	1	4	4	2	1	2	3	rs145210688	by1000genomes	TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr8:61135309G>A	uc003xtz.1	-	7	885	c.637C>T	c.(637-639)CGG>TGG	p.R213W	CA8_uc003xua.1_Missense_Mutation_p.R213W	NM_004056	NP_004047	P35219	CAH8_HUMAN	carbonic anhydrase VIII	213					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				CAGTAATCCCGCAGCAGAGGG	0.438													15	77					0	0	0	0	A	61135309	A	A	61135309	3	1	158	1	0	0	0	0	1	0	0	0	2535	1086	38	1	243	1	CA8	8	61135309	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08	1643081	61135309	85228713	20	29011											
KIAA1539	80256	broad.mit.edu	37	chr9	35107547	35107547	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccagcaggaagcagccttCgcttggtggggcaggggcct	6	7	16	12	1	0	0	0	0	0	0	2	1	1	1	3	6	3	4	3	6	1	2			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr9:35107547C>T	uc003zwl.2	-	3	1050	c.725G>A	c.(724-726)CGA>CAA	p.R242Q	KIAA1539_uc003zwm.2_Missense_Mutation_p.R242Q|KIAA1539_uc003zwn.2_5'UTR|KIAA1539_uc003zwo.2_Missense_Mutation_p.R242Q|KIAA1539_uc003zwp.1_Missense_Mutation_p.R242Q|KIAA1539_uc010mkk.1_RNA	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	242						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AAGCAGCCTTCGCTTGGTGGG	0.697													5	139					0	0	0	0	T	35107547	T	T	35107547	3	4	158	1	0	0	0	0	1	0	0	0	8281	884	31	1	919	1	KIAA1539	9	35107547	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08		35107547	106105884	21	29012											
CHAT	1103	broad.mit.edu	37	chr10	50872950	50872952	+	In_Frame_Del	DEL	CTT	-	-																															ctttcacagctgcaaagagaCttcttctagcaagtttgcaa																										TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr10:50872950_50872952delCTT	uc001jhz.2	+	15	2258_2260	c.2105_2107delCTT	c.(2104-2109)ACTTCT>ACT	p.S705del	CHAT_uc001jhv.1_In_Frame_Del_p.S587del|CHAT_uc001jhx.1_In_Frame_Del_p.S587del|CHAT_uc001jhy.1_In_Frame_Del_p.S587del|CHAT_uc001jia.2_In_Frame_Del_p.S587del|CHAT_uc010qgs.1_Intron	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	705					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TGCAAAGAGACTTCTTCTAGCAA	0.502													---	---	---								-	50872952	-	-	50872950	7	5	158	1	0	1	0	1	0	0	0	0	3328	565	20	0	2207	0	CHAT	10	50872950	In_Frame_Del	DEL	CTT	TCGA-CR-7392-01A-11D-2012-08		50872950	84661797	22	29013											
ASCL3	56676	broad.mit.edu	37	chr11	8959494	8959494	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatcgggaaagagaaggggCagggttcactgtaatttccc	11	8	14	8	1	1	1	1	0	0	1	3	3	2	2	1	4	0	4	1	4	3	3			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr11:8959494C>T	uc001mhd.1	-	2	275	c.215G>A	c.(214-216)TGC>TAC	p.C72Y		NM_020646	NP_065697	Q9NQ33	ASCL3_HUMAN	ASCL3	71					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleolus	DNA binding				0				Epithelial(150;1.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0228)		AGAGAAGGGGCAGGGTTCACT	0.577													6	77					0	0	0	0	T	8959494	T	T	8959494	3	4	158	1	0	0	0	0	1	0	0	0	1037	710	25	4	334	4	ASCL3	11	8959494	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08		8959494	126047022	23	29014											
FJX1	24147	broad.mit.edu	37	chr11	35640755	35640755	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acccggagcagattcagggcGaggccctgtcttactatctg	8	9	12	12	2	3	1	1	0	2	1	3	3	3	2	2	3	2	1	2	3	2	3			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr11:35640755G>A	uc001mwh.2	+	1	1021	c.571G>A	c.(571-573)GAG>AAG	p.E191K		NM_014344	NP_055159	Q86VR8	FJX1_HUMAN	four jointed box 1 precursor	191						extracellular space					0	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)				GATTCAGGGCGAGGCCCTGTC	0.731													7	25					0	0	0	0	A	35640755	A	A	35640755	3	1	158	1	0	0	0	0	1	0	0	0	5933	1059	37	1	573	1	FJX1	11	35640755	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08	26681261	35640755	99365761	24	29015											
AMBRA1	55626	broad.mit.edu	37	chr11	46564921	46564921	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgggataattctgttccatCtatggggatctctggttcgt	6	16	12	7	1	3	0	0	0	3	0	6	2	4	2	1	4	0	2	1	4	2	5			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr11:46564921C>T	uc010rgu.1	-	7	1006	c.646G>A	c.(646-648)GAT>AAT	p.D216N	AMBRA1_uc010rgt.1_5'Flank|AMBRA1_uc009ylc.1_Missense_Mutation_p.D216N|AMBRA1_uc001ncu.1_Missense_Mutation_p.D216N|AMBRA1_uc001ncv.2_Missense_Mutation_p.D216N|AMBRA1_uc001ncw.2_Missense_Mutation_p.D216N|AMBRA1_uc001ncx.2_Missense_Mutation_p.D216N	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	216					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		TCTGTTCCATCTATGGGGATC	0.542													16	98					0	0	0	0	T	46564921	T	T	46564921	3	4	158	1	0	0	0	0	1	0	0	0	565	913	32	2	3032	2	AMBRA1	11	46564921	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08	10924166	46564921	88441595	25	29016											
OR4A16	81327	broad.mit.edu	37	chr11	55111250	55111250	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgttgtgccttgacacctacTttataggactcactgtggtt	7	16	9	9	0	1	1	1	1	0	0	1	2	1	2	2	2	2	2	2	2	3	7			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr11:55111250T>A	uc010rie.1	+	1	574	c.574T>A	c.(574-576)TTT>ATT	p.F192I		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						TGACACCTACTTTATAGGACT	0.423													7	145					0	0	0	0	A	55111250	A	A	55111250	3	1	158	1	0	0	0	0	1	0	0	0	11095	1609	56	5	576	5	OR4A16	11	55111250	Missense_Mutation	SNP	T	TCGA-CR-7392-01A-11D-2012-08	8546329	55111250	79895266	26	29017											
TIGD3	220359	broad.mit.edu	37	chr11	65124576	65124576	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcccctgcccaccaaagctGatgccctccgggccctgggc	6	5	11	19	1	0	1	0	1	0	0	1	1	1	1	7	2	4	1	7	2	1	0			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr11:65124576G>A	uc001odo.3	+	2	1460	c.1297G>A	c.(1297-1299)GAT>AAT	p.D433N		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	433					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CACCAAAGCTGATGCCCTCCG	0.562													12	109					0	0	0	0	A	65124576	A	A	65124576	3	1	158	1	0	0	0	0	1	0	0	0	15963	1290	45	2	1299	2	TIGD3	11	65124576	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08	10013326	65124576	69881940	27	29018											
PELI3	246330	broad.mit.edu	37	chr11	66238754	66238754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggggacaagggccgccggcGaagccgcctggcactgagcc	7	3	17	14	4	0	1	0	1	0	0	0	3	0	2	5	5	2	1	5	5	2	0			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr11:66238754G>A	uc001oic.3	+	4	430	c.266G>A	c.(265-267)CGA>CAA	p.R89Q	PELI3_uc001oib.2_Missense_Mutation_p.R89Q|PELI3_uc001oid.3_Missense_Mutation_p.R65Q|PELI3_uc001oie.3_5'UTR|PELI3_uc010rpd.1_5'Flank	NM_145065	NP_659502	Q8N2H9	PELI3_HUMAN	pellino 3 alpha isoform 1	89						cytosol	protein binding			ovary(1)	1						GGCCGCCGGCGAAGCCGCCTG	0.597													6	184					0	0	0	0	A	66238754	A	A	66238754	3	1	158	1	0	0	0	0	1	0	0	0	11777	1058	37	1	276	1	PELI3	11	66238754	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08	1114178	66238754	68767762	28	29019											
ATN1	1822	broad.mit.edu	37	chr12	7044927	7044927	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacccacctccactctttcCtccttcccctcaaccgccag	6	9	2	24	1	2	0	1	0	1	0	6	0	6	0	10	0	1	0	10	0	1	2			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr12:7044927C>G	uc001qrw.1	+	5	734	c.497C>G	c.(496-498)CCT>CGT	p.P166R	ATN1_uc001qrx.1_Missense_Mutation_p.P166R|ATN1_uc001qry.1_Missense_Mutation_p.P165R	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	166					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCACTCTTTCCTCCTTCCCCT	0.592													4	149					0	0	0	0	G	7044927	G	G	7044927	3	3	158	1	0	0	0	0	1	0	0	0	1113	681	24	4	511	4	ATN1	12	7044927	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08		7044927	126806968	29	29020											
PRICKLE1	144165	broad.mit.edu	37	chr12	42854281	42854281	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgtactggcttctcttcaGgcaggattttctctggacac	7	14	10	10	0	3	0	1	0	2	0	5	3	3	2	0	4	1	3	0	4	1	5			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr12:42854281G>A	uc010skv.1	-	8	2113	c.1826C>T	c.(1825-1827)CCT>CTT	p.P609L	PRICKLE1_uc001rnl.2_Missense_Mutation_p.P609L|PRICKLE1_uc010skw.1_Missense_Mutation_p.P609L|PRICKLE1_uc001rnm.2_Missense_Mutation_p.P609L|PRICKLE1_uc001rnk.1_5'Flank	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	609					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		CTTCTCTTCAGGCAGGATTTT	0.463													5	111					0	0	0	0	A	42854281	A	A	42854281	3	1	158	1	0	0	0	0	1	0	0	0	12548	1000	35	4	673	4	PRICKLE1	12	42854281	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08	35809354	42854281	90997614	30	29021											
ACCN2	41	broad.mit.edu	37	chr12	50472360	50472360	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgcatggtgcacatgccaGgtcaggcctggggctccgag	6	6	16	13	2	1	0	1	0	0	0	2	1	2	0	4	5	2	3	4	5	0	0			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr12:50472360G>A	uc001rvw.2	+	6	1223	c.994G>A	c.(994-996)GGG>AGG	p.G332R	ACCN2_uc001rvv.2_Missense_Mutation_p.G332R|ACCN2_uc009zln.2_Missense_Mutation_p.G123R|ACCN2_uc009zlo.2_Missense_Mutation_p.G332R	NM_001095	NP_001086	P78348	ACCN2_HUMAN	amiloride-sensitive cation channel 2, neuronal	332	Extracellular (By similarity).				calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)	GCACATGCCAGGTCAGGCCTG	0.592													4	131					0	0	0	0	A	50472360	A	A	50472360	3	1	158	1	0	0	0	0	1	0	0	0	129	1014	35	4	1012	4	ACCN2	12	50472360	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08	7618079	50472360	83379535	31	29022											
TRPM1	4308	broad.mit.edu	37	chr15	31362283	31362283	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggaattcaagaactccatagGaatctgttgggtagctctgg	11	11	12	7	0	3	1	1	0	2	1	4	3	4	3	1	4	2	3	1	4	6	4			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr15:31362283G>T	uc001zfm.2	-	3	292	c.164C>A	c.(163-165)TCC>TAC	p.S55Y	TRPM1_uc010azy.2_5'Flank|TRPM1_uc001zfl.2_5'Flank|TRPM1_uc001zfn.3_Missense_Mutation_p.S55Y|uc010ubn.1_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	55	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AACTCCATAGGAATCTGTTGG	0.483													12	557					2.27111e-07	8.06969e-07	1	0	T	31362283	T	T	31362283	3	4	158	1	0	0	0	0	1	0	0	0	16652	1174	41	2	4747	2	TRPM1	15	31362283	Missense_Mutation	SNP	G	TCGA-CR-7392-01A-11D-2012-08		31362283	71169109	32	29023											
KBTBD13	390594	broad.mit.edu	37	chr15	65369216	65369216	+	Frame_Shift_Del	DEL	C	-	-																															ggccagctcttccaagccgaCcgcgccctgctggtggagca																										TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr15:65369216delC	uc010uis.1	+	1	63	c.63delC	c.(61-63)GACfs	p.D21fs	RASL12_uc010uir.1_5'Flank	NM_001101362	NP_001094832	C9JR72	KBTBD_HUMAN	hypothetical protein LOC390594	21	BTB.					cytoplasm					0						TCCAAGCCGACCGCGCCCTGC	0.721													---	---	---								-	65369216	-	-	65369216	7	5	158	1	0	1	0	1	0	0	0	0	8031	506	18	0	65	0	KBTBD13	15	65369216	Frame_Shift_Del	DEL	C	TCGA-CR-7392-01A-11D-2012-08	34006933	65369216	37162176	33	29024											
ZNF780B	163131	broad.mit.edu	37	chr19	40540672	40540672	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcttcctacactccttacaTacaaagggtttcgcactgga	10	12	7	12	1	1	0	0	0	1	0	4	1	3	1	2	2	3	2	2	2	4	5			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr19:40540672T>A	uc002omu.2	-	5	2159	c.2094A>T	c.(2092-2094)GTA>GTT	p.V698V	ZNF780B_uc002omv.2_Silent_p.V550V	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	698	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					ACTCCTTACATACAAAGGGTT	0.388													10	137					0	0	0	0	A	40540672	A	A	40540672	2	1	158	1	0	0	0	0	0	0	0	1	18220	1393	49	5		5	ZNF780B	19	40540672	Silent	SNP	T	TCGA-CR-7392-01A-11D-2012-08		40540672	18588311	34	29025											
TIAM1	7074	broad.mit.edu	37	chr21	32502548	32502548	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tacctgcactcgccaaagctCgaacctgcagcgcttccgtg	8	8	9	16	4	0	0	0	0	0	0	3	1	1	0	4	0	6	4	4	0	3	2			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr21:32502548C>G	uc002yow.1	-	26	4500	c.4028G>C	c.(4027-4029)CGA>CCA	p.R1343P	TIAM1_uc011adk.1_Missense_Mutation_p.R1343P|TIAM1_uc011adl.1_Missense_Mutation_p.R1283P	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1343	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						CGCCAAAGCTCGAACCTGCAG	0.483													3	214					0	0	0	0	G	32502548	G	G	32502548	3	3	158	1	0	0	0	0	1	0	0	0	15956	884	31	3	763	3	TIAM1	21	32502548	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08		32502548	15627347	35	29026											
DEPDC5	9681	broad.mit.edu	37	chr22	32289633	32289633	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacaaccgcacagaccggCtggagtggtgcagctgttat	10	8	13	10	2	0	2	0	1	0	1	0	3	0	3	2	3	4	5	2	3	3	1			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chr22:32289633C>G	uc003als.2	+	38	4148	c.4006C>G	c.(4006-4008)CTG>GTG	p.L1336V	DEPDC5_uc011als.1_Missense_Mutation_p.L1267V|DEPDC5_uc011alu.1_Missense_Mutation_p.L1367V|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.L1358V|DEPDC5_uc003alu.2_Missense_Mutation_p.L785V|DEPDC5_uc003alv.2_RNA|DEPDC5_uc003alw.2_Missense_Mutation_p.L634V|DEPDC5_uc011alx.1_Missense_Mutation_p.L184V|DEPDC5_uc010gwk.2_Missense_Mutation_p.L362V|DEPDC5_uc011aly.1_Missense_Mutation_p.L184V	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1336					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						CACAGACCGGCTGGAGTGGTG	0.557													5	59					0	0	0	0	G	32289633	G	G	32289633	3	3	158	1	0	0	0	0	1	0	0	0	4464	796	28	4	4240	4	DEPDC5	22	32289633	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08		32289633	19014933	36	29027											
AWAT1	158833	broad.mit.edu	37	chrX	69455618	69455618	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtttacatccttgtggccGctaccagtgctttactttgc	5	16	8	12	1	0	0	0	0	0	0	1	0	1	0	3	1	5	3	3	1	3	7			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chrX:69455618G>A	uc004dxy.2	+	2	170	c.129G>A	c.(127-129)CCG>CCA	p.P43P		NM_001013579	NP_001013597	Q58HT5	AWAT1_HUMAN	wax synthase 1	43	Helical; (Potential).				lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			ovary(3)	3						CCTTGTGGCCGCTACCAGTGC	0.488													6	243					0	0	0	0	A	69455618	A	A	69455618	2	1	158	1	0	0	0	0	0	0	0	1	1236	1074	38	1		1	AWAT1	23	69455618	Silent	SNP	G	TCGA-CR-7392-01A-11D-2012-08		69455618	85814942	37	29028											
F9	2158	broad.mit.edu	37	chrX	138643694	138643694	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttaataggtgaacataatAttgaggagacagaacataca	18	11	8	4	0	0	4	0	2	0	2	0	5	0	4	0	2	3	0	0	2	7	7			TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chrX:138643694A>T	uc004fas.1	+	8	879	c.850A>T	c.(850-852)ATT>TTT	p.I284F	F9_uc004fat.1_Missense_Mutation_p.I246F	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	284	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGAACATAATATTGAGGAGAC	0.333													13	90					0	0	0	0	T	138643694	T	T	138643694	3	4	158	1	0	0	0	0	1	0	0	0	5379	449	16	5	880	5	F9	23	138643694	Missense_Mutation	SNP	A	TCGA-CR-7392-01A-11D-2012-08	69188076	138643694	16626866	38	29029											
HAUS7	55559	broad.mit.edu	37	chrX	152730472	152730472	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcttcacctctgttgggaccCctttcagtgagctgaacctg	6	13	9	13	0	4	2	2	2	2	0	4	3	4	3	4	1	2	2	4	1	1	3	rs141087618		TCGA-CR-7392-01A-11D-2012-08	TCGA-CR-7392-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0616d3e5-9641-4329-a65a-19f4c6918e1c	6af45747-7234-43ab-a250-f346349301fd	g.chrX:152730472C>A	uc004fho.1	-	3	854	c.296G>T	c.(295-297)GGG>GTG	p.G99V	HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA|HAUS7_uc004fhn.1_Missense_Mutation_p.G99V|HAUS7_uc004fhp.1_Intron|HAUS7_uc011myq.1_RNA	NM_017518	NP_059988	Q99871	HAUS7_HUMAN	HAUS augmin-like complex subunit 7	99					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding				0						TGTTGGGACCCCTTTCAGTGA	0.577													17	359					1.56452e-12	5.80612e-12	1	0	A	152730472	A	A	152730472	3	1	158	1	0	0	0	0	1	0	0	0	7010	623	22	4	842	4	HAUS7	23	152730472	Missense_Mutation	SNP	C	TCGA-CR-7392-01A-11D-2012-08	14086778	152730472	2540088	39	29030											
RASAL1	8437	broad.mit.edu	37	chr12	113552686	113552686	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacggctaatcacaggcttcAggacctcgtgcaggtagggc	9	7	13	12	2	2	0	2	0	0	0	3	1	2	1	1	5	1	4	1	5	2	3			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr12:113552686A>G	uc001tum.1	-	13	1393	c.1100T>C	c.(1099-1101)CTG>CCG	p.L367P	RASAL1_uc010syp.1_Missense_Mutation_p.L367P|RASAL1_uc001tul.2_Missense_Mutation_p.L367P|RASAL1_uc001tun.1_Missense_Mutation_p.L367P|RASAL1_uc010syq.1_Missense_Mutation_p.L367P|RASAL1_uc001tuo.3_Missense_Mutation_p.L367P|RASAL1_uc010syr.1_Missense_Mutation_p.L367P	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	367	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						CACAGGCTTCAGGACCTCGTG	0.657													4	329					0	0	0	0	G	113552686	G	G	113552686	3	3	159	1	0	0	0	0	1	0	0	0	13128	188	7	5	1354	5	RASAL1	12	113552686	Missense_Mutation	SNP	A	TCGA-CR-7393-01A-11D-2012-08		113552686	20299209	1	29031											
AKAP11	11215	broad.mit.edu	37	chr13	42874583	42874583	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttttggcagtgcatttaaAgacttacagaaaggagtctc	13	12	10	6	0	1	2	0	0	1	2	2	3	1	3	0	2	2	3	0	2	4	5			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr13:42874583A>C	uc001uys.1	+	8	1876	c.1701A>C	c.(1699-1701)AAA>AAC	p.K567N		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	567					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GTGCATTTAAAGACTTACAGA	0.323													3	59					0	0	0	0	C	42874583	C	C	42874583	3	2	159	1	0	0	0	0	1	0	0	0	447	69	3	5	1723	5	AKAP11	13	42874583	Missense_Mutation	SNP	A	TCGA-CR-7393-01A-11D-2012-08		42874583	72295295	2	29032											
TP53	7157	broad.mit.edu	37	chr17	7579566	7579566	+	Frame_Shift_Del	DEL	C	-	-																															cggggacagcatcaaatcatCcattgcttgggacggcaagg																										TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr17:7579566delC	uc002gim.2	-	4	315	c.121delG	c.(121-123)GATfs	p.D41fs	TP53_uc002gig.1_Frame_Shift_Del_p.D41fs|TP53_uc002gih.2_Frame_Shift_Del_p.D41fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.D41fs|TP53_uc010cni.1_Frame_Shift_Del_p.D41fs|TP53_uc002gij.2_Frame_Shift_Del_p.D41fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.D2fs|TP53_uc010cnk.1_Frame_Shift_Del_p.D56fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	41	Transcription activation (acidic).|Interaction with HRMT1L2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.D41fs*3(1)|p.S37fs*79(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCAAATCATCCATTGCTTGG	0.458		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7579566	-	-	7579566	7	5	159	1	0	1	0	1	0	0	0	0	16448	855	30	0	1181	0	TP53	17	7579566	Frame_Shift_Del	DEL	C	TCGA-CR-7393-01A-11D-2012-08		7579566	73615644	3	29033											
CUEDC1	404093	broad.mit.edu	37	chr17	55957076	55957076	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctcttcatccgagctatcAggttccaaagtcctttccaa	9	12	7	13	1	3	0	2	0	1	0	7	1	7	0	4	2	1	3	4	2	3	4			TCGA-CR-7393-01A-11D-2012-08	TCGA-CR-7393-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f59ef1d2-2fc0-44a0-9d2f-c4efd9e79f5d	6dbfbb98-28ba-4e3a-ae25-dc705ad70e7d	g.chr17:55957076A>G	uc002ivd.1	-	3	1079	c.360T>C	c.(358-360)CCT>CCC	p.P120P	CUEDC1_uc002ive.1_Silent_p.P120P	NM_017949	NP_060419	Q9NWM3	CUED1_HUMAN	CUE domain-containing 1	120	Pro-rich.									skin(2)	2						CCGAGCTATCAGGTTCCAAAG	0.408													3	99					0	0	0	0	G	55957076	G	G	55957076	2	3	159	1	0	0	0	0	0	0	0	1	4069	175	7	5		5	CUEDC1	17	55957076	Silent	SNP	A	TCGA-CR-7393-01A-11D-2012-08	48377510	55957076	25238134	4	29034											
RERE	473	broad.mit.edu	37	chr1	8425906	8425906	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggggtctggagggtgtgttGacgggtgtggacgcggtgcg	3	9	24	5	4	1	1	0	1	1	0	1	3	1	3	0	7	1	1	0	7	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:8425906G>A	uc001ape.2	-	14	2223	c.1413C>T	c.(1411-1413)GTC>GTT	p.V471V	RERE_uc001apf.2_Silent_p.V471V|RERE_uc010nzx.1_Silent_p.V203V|RERE_uc001apd.2_5'UTR	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	471					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AGGGTGTGTTGACGGGTGTGG	0.632													4	63					0	0	0	0	A	8425906	A	A	8425906	2	1	160	1	0	0	0	0	0	0	0	1	13296	1277	45	2		2	RERE	1	8425906	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08		8425906	240824715	1	29035											
MRTO4	51154	broad.mit.edu	37	chr1	19583616	19583616	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggtcggagcccatctgatGaatacaaagacaacctgcac	13	7	10	11	1	1	3	0	2	1	1	2	4	1	4	2	2	4	1	2	2	4	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:19583616G>A	uc001bbs.2	+	4	505	c.250G>A	c.(250-252)GAA>AAA	p.E84K		NM_016183	NP_057267	Q9UKD2	MRT4_HUMAN	mRNA turnover 4 homolog	84					ribosome biogenesis	nuclear membrane|nucleolus					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.87e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00301)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCATCTGATGAATACAAAGA	0.537													18	234					0	0	0	0	A	19583616	A	A	19583616	3	1	160	1	0	0	0	0	1	0	0	0	9905	1291	45	2	264	2	MRTO4	1	19583616	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	11157710	19583616	229667005	2	29036											
PHC2	1912	broad.mit.edu	37	chr1	33832909	33832909	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctctgtgctggggtaggcaGaggctggctaccgcccggcg	4	7	18	12	3	1	1	0	0	1	1	1	1	1	1	2	6	2	6	2	6	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:33832909G>A	uc001bxg.1	-	6	838	c.784C>T	c.(784-786)CTG>TTG	p.L262L	PHC2_uc001bxh.1_Silent_p.L233L|PHC2_uc009vuh.1_Silent_p.L262L|PHC2_uc001bxi.1_Silent_p.L262L	NM_198040	NP_932157	Q8IXK0	PHC2_HUMAN	polyhomeotic-like 2 isoform a	262					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGGGTAGGCAGAGGCTGGCTA	0.632											OREG0013344	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	129					0	0	0	0	A	33832909	A	A	33832909	2	1	160	1	0	0	0	0	0	0	0	1	11872	933	33	2		2	PHC2	1	33832909	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	14249293	33832909	215417712	3	29037											
DNALI1	7802	broad.mit.edu	37	chr1	38027808	38027808	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggagaagaagcacaatgagGagattcagttcctgaagcga	16	6	13	6	1	1	5	1	2	0	3	2	8	2	5	1	2	2	2	1	2	4	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:38027808G>A	uc001cbj.2	+	5	779	c.769G>A	c.(769-771)GAG>AAG	p.E257K	DNALI1_uc010oie.1_RNA	NM_003462	NP_003453	O14645	IDLC_HUMAN	dynein, axonemal, light intermediate chain 1	235	Potential.				cellular component movement|single fertilization	axonemal dynein complex	microtubule motor activity			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCACAATGAGGAGATTCAGTT	0.587													3	24					0	0	0	0	A	38027808	A	A	38027808	3	1	160	1	0	0	0	0	1	0	0	0	4681	1175	41	2	787	2	DNALI1	1	38027808	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	4194899	38027808	211222813	4	29038											
KDM4A	9682	broad.mit.edu	37	chr1	44169928	44169928	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcagacatgcgcttcaatGagattttcacagagaaagag	14	9	9	9	1	3	4	3	1	0	4	3	6	3	4	1	0	1	1	1	0	2	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:44169928G>A	uc001cjx.2	+	22	3248	c.3082G>A	c.(3082-3084)GAG>AAG	p.E1028K	uc001cjy.2_Intron|ST3GAL3_uc009vwu.1_5'Flank|KDM4A_uc010oki.1_3'UTR	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	1028					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						GCGCTTCAATGAGATTTTCAC	0.438													6	153					0	0	0	0	A	44169928	A	A	44169928	3	1	160	1	0	0	0	0	1	0	0	0	8167	1291	45	2	3164	2	KDM4A	1	44169928	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	6142120	44169928	205080693	5	29039											
POMGNT1	55624	broad.mit.edu	37	chr1	46660524	46660524	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgatgccggcacctccttttCgtcccacgaaggcccatgtg	6	10	10	15	3	0	1	0	1	0	0	3	2	2	1	5	2	1	1	5	2	1	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:46660524C>T	uc001cpe.2	-	7	808	c.644G>A	c.(643-645)CGA>CAA	p.R215Q	POMGNT1_uc010olx.1_Missense_Mutation_p.R193Q|POMGNT1_uc010oly.1_RNA|POMGNT1_uc010olz.1_Missense_Mutation_p.R72Q|POMGNT1_uc001cpg.2_Missense_Mutation_p.R215Q|POMGNT1_uc001cpf.2_Intron|POMGNT1_uc001cph.1_5'Flank|POMGNT1_uc001cpi.1_5'Flank	NM_017739	NP_060209	Q8WZA1	PMGT1_HUMAN	O-linked mannose	215	Lumenal (Potential).				protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACCTCCTTTTCGTCCCACGAA	0.617													37	223					0	0	0	0	T	46660524	T	T	46660524	3	4	160	1	0	0	0	0	1	0	0	0	12298	884	31	1	1402	1	POMGNT1	1	46660524	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	2490596	46660524	202590097	6	29040											
INADL	10207	broad.mit.edu	37	chr1	62235043	62235043	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctcagaagtcaaaatctcgGaaaagttgatatcttcgtga	14	11	8	8	2	4	3	2	2	2	1	6	4	4	4	1	1	0	1	1	1	6	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:62235043G>A	uc001dab.2	+	5	587	c.473G>A	c.(472-474)GGA>GAA	p.G158E	INADL_uc009waf.1_Missense_Mutation_p.G158E|INADL_uc001daa.2_Missense_Mutation_p.G158E|INADL_uc001dad.3_5'Flank	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	158	PDZ 1.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CAAAATCTCGGAAAAGTTGAT	0.433													8	70					0	0	0	0	A	62235043	A	A	62235043	3	1	160	1	0	0	0	0	1	0	0	0	7770	1174	41	2	487	2	INADL	1	62235043	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	15574519	62235043	187015578	7	29041											
DOCK7	85440	broad.mit.edu	37	chr1	63003606	63003606	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggtgatggagatgcaggtgGagtaagtaagctgcagggta	12	8	18	3	0	0	2	0	1	0	1	0	4	0	3	0	5	3	6	0	5	3	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:63003606G>T	uc001daq.2	-	28	3461	c.3427C>A	c.(3427-3429)CCA>ACA	p.P1143T	DOCK7_uc001dan.2_Missense_Mutation_p.P1004T|DOCK7_uc001dao.2_Missense_Mutation_p.P1004T|DOCK7_uc001dap.2_Missense_Mutation_p.P1112T|DOCK7_uc001dam.2_Missense_Mutation_p.P323T|DOCK7_uc010oov.1_5'Flank	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1143					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						GATGCAGGTGGAGTAAGTAAG	0.393													5	47					0.000602214	0.00064505	1	0	T	63003606	T	T	63003606	3	4	160	1	0	0	0	0	1	0	0	0	4714	1174	41	2	3087	2	DOCK7	1	63003606	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	768563	63003606	186247015	8	29042											
ROR1	4919	broad.mit.edu	37	chr1	64643982	64643982	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcggtcctgggagggactctCaagtcacacaagctctacta	10	9	10	12	1	3	0	2	0	2	0	6	2	4	2	1	3	2	1	1	3	4	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:64643982C>G	uc001dbj.2	+	9	2657	c.2258C>G	c.(2257-2259)TCA>TGA	p.S753*	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	753	Ser/Thr-rich.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						GAGGGACTCTCAAGTCACACA	0.498													5	67					0	0	0	0	G	64643982	G	G	64643982	4	3	160	1	0	0	0	0	0	1	0	0	13591	838	29	2	2300	2	ROR1	1	64643982	Nonsense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	1640376	64643982	184606639	9	29043											
RAVER2	55225	broad.mit.edu	37	chr1	65278428	65278428	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgttaaataggctgcctCtaagaatcaaacttcactct	12	15	5	9	0	4	1	2	0	2	1	4	1	4	1	1	1	2	2	1	1	6	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:65278428C>G	uc001dbs.1	+	10	1727	c.1649C>G	c.(1648-1650)TCT>TGT	p.S550C	RAVER2_uc001dbt.1_Missense_Mutation_p.S442C|RAVER2_uc010opb.1_Intron	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	563						cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						TAGGCTGCCTCTAAGAATCAA	0.348													4	41					0	0	0	0	G	65278428	G	G	65278428	3	3	160	1	0	0	0	0	1	0	0	0	13160	913	32	2	1687	2	RAVER2	1	65278428	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	634446	65278428	183972193	10	29044											
COL11A1	1301	broad.mit.edu	37	chr1	103471837	103471837	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccctttttccaggttttcccGttggaccagggggaccctgg	4	12	12	13	1	0	0	0	0	0	0	2	2	2	2	5	5	0	2	5	5	0	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:103471837G>A	uc001dul.2	-	16	2036	c.1718C>T	c.(1717-1719)ACG>ATG	p.T573M	COL11A1_uc001duk.2_Translation_Start_Site|COL11A1_uc001dum.2_Missense_Mutation_p.T585M|COL11A1_uc001dun.2_Missense_Mutation_p.T534M|COL11A1_uc009weh.2_Missense_Mutation_p.T457M	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	573	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGGTTTTCCCGTTGGACCAGG	0.348													11	63					0	0	0	0	A	103471837	A	A	103471837	3	1	160	1	0	0	0	0	1	0	0	0	3682	1145	40	1	3910	1	COL11A1	1	103471837	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	38193409	103471837	145778784	11	29045											
NOTCH2	4853	broad.mit.edu	37	chr1	120480557	120480557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatccagatggacataggCactgggactctgcttttttc	8	12	9	12	0	1	1	0	0	1	1	3	3	2	3	2	3	1	2	2	3	1	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:120480557C>T	uc001eik.2	-	20	3516	c.3260G>A	c.(3259-3261)TGC>TAC	p.C1087Y	NOTCH2_uc001eil.2_Missense_Mutation_p.C1087Y	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1087	EGF-like 28.|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGACATAGGCACTGGGACTC	0.517			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				10	47					0	0	0	0	T	120480557	T	T	120480557	3	4	160	1	0	0	0	0	1	0	0	0	10602	710	25	4	4215	4	NOTCH2	1	120480557	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	17008720	120480557	128770064	12	29046											
NOTCH2	4853	broad.mit.edu	37	chr1	120548096	120548096	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtaaaccctgaggcacatcGgcacgtggctttccccagca	9	8	10	14	2	0	1	0	1	0	0	2	1	1	1	3	3	2	5	3	3	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:120548096G>A	uc001eik.2	-	3	527	c.271C>T	c.(271-273)CGA>TGA	p.R91*	NOTCH2_uc001eil.2_Nonsense_Mutation_p.R91*|NOTCH2_uc001eim.3_Nonsense_Mutation_p.R8*	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	91	Extracellular (Potential).|EGF-like 2.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGGCACATCGGCACGTGGCT	0.557			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				10	112					0	0	0	0	A	120548096	A	A	120548096	4	1	160	1	0	0	0	0	0	1	0	0	10602	1124	39	1	7272	1	NOTCH2	1	120548096	Nonsense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	67539	120548096	128702525	13	29047											
RPS27	6232	broad.mit.edu	37	chr1	153964115	153964115	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttggctgctccactgtcctCtgccagcctacaggaggaaa	8	9	11	13	0	1	0	0	0	1	0	3	2	3	2	4	3	4	3	4	3	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:153964115C>G	uc001fdv.2	+	3	223	c.189C>G	c.(187-189)CTC>CTG	p.L63L		NM_001030	NP_001021	P42677	RS27_HUMAN	ribosomal protein S27	63					cell proliferation|endocrine pancreas development|mitotic prometaphase|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleus	DNA binding|structural constituent of ribosome|zinc ion binding				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCACTGTCCTCTGCCAGCCTA	0.398													5	51					0	0	0	0	G	153964115	G	G	153964115	2	3	160	1	0	0	0	0	0	0	0	1	13703	900	32	2		2	RPS27	1	153964115	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	33416019	153964115	95286506	14	29048											
CRABP2	1382	broad.mit.edu	37	chr1	156670736	156670736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaagttaatctctgtggtgCgcacggtggtggaggttttg	6	14	16	5	2	1	1	0	1	1	0	2	2	1	2	0	5	1	3	0	5	2	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:156670736C>T	uc001fpr.2	-	2	316	c.179G>A	c.(178-180)CGC>CAC	p.R60H		NM_001878	NP_001869	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	60					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity	p.R60C(1)		upper_aerodigestive_tract(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)	CTCTGTGGTGCGCACGGTGGT	0.552													4	96					0	0	0	0	T	156670736	T	T	156670736	3	4	160	1	0	0	0	0	1	0	0	0	3859	768	27	1	249	1	CRABP2	1	156670736	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	2706621	156670736	92579885	15	29049											
CNTN2	6900	broad.mit.edu	37	chr1	205039123	205039123	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccctttgaggtcaagatcCgcagctacaaccgccgcggg	8	6	12	15	5	1	2	1	1	0	1	2	2	2	2	4	2	3	2	4	2	3	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:205039123C>T	uc001hbr.2	+	18	2634	c.2365C>T	c.(2365-2367)CGC>TGC	p.R789C	CNTN2_uc001hbq.1_Missense_Mutation_p.R680C|CNTN2_uc001hbs.2_Missense_Mutation_p.R577C	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	789	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGTCAAGATCCGCAGCTACAA	0.662													9	71					0	0	0	0	T	205039123	T	T	205039123	3	4	160	1	0	0	0	0	1	0	0	0	3656	652	23	1	2431	1	CNTN2	1	205039123	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	48368387	205039123	44211498	16	29050											
ESRRG	2104	broad.mit.edu	37	chr1	216680464	216680464	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagcttcataatcctgcagCgcttcatgtaagacatcctg	10	11	7	13	1	2	1	2	0	0	1	4	1	4	1	3	0	3	4	3	0	2	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:216680464C>A	uc001hkw.1	-	7	1360	c.1194G>T	c.(1192-1194)GCG>GCT	p.A398A	ESRRG_uc001hky.1_Silent_p.A375A|ESRRG_uc009xdp.1_Silent_p.A375A|ESRRG_uc001hkz.1_Silent_p.A336A|ESRRG_uc010puc.1_Silent_p.A375A|ESRRG_uc001hla.1_Silent_p.A375A|ESRRG_uc001hlb.1_Silent_p.A375A|ESRRG_uc010pud.1_Silent_p.A206A|ESRRG_uc001hlc.1_Silent_p.A375A|ESRRG_uc001hld.1_Silent_p.A375A|ESRRG_uc001hkx.1_Silent_p.A410A|ESRRG_uc009xdo.1_Silent_p.A375A	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	398					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	AATCCTGCAGCGCTTCATGTA	0.478													11	63					2.27111e-07	2.45318e-07	1	0	A	216680464	A	A	216680464	2	1	160	1	0	0	0	0	0	0	0	1	5286	755	27	3		3	ESRRG	1	216680464	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	11641341	216680464	32570157	17	29051											
CDC42BPA	8476	broad.mit.edu	37	chr1	227300480	227300480	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggacatggcgagcaagtttCtgtttttgggtgtgcaattc	7	14	13	7	2	1	0	0	0	1	0	2	2	1	1	0	3	2	4	0	3	2	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:227300480C>T	uc001hqr.2	-	13	2725	c.1782G>A	c.(1780-1782)CAG>CAA	p.Q594Q	CDC42BPA_uc001hqs.2_Intron|CDC42BPA_uc009xes.2_Silent_p.Q594Q|CDC42BPA_uc010pvs.1_Silent_p.Q594Q	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	594	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				GAGCAAGTTTCTGTTTTTGGG	0.468													16	210					0	0	0	0	T	227300480	T	T	227300480	2	4	160	1	0	0	0	0	0	0	0	1	3087	912	32	2		2	CDC42BPA	1	227300480	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	10620016	227300480	21950141	18	29052											
DISC1	27185	broad.mit.edu	37	chr1	231830190	231830190	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtggagaagcagaaggctGcccaccatccagagaggctg	12	4	14	11	1	0	3	0	0	0	3	1	5	1	3	3	3	2	3	3	3	2	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:231830190G>A	uc001huz.2	+	2	739	c.686G>A	c.(685-687)TGC>TAC	p.C229Y	TSNAX-DISC1_uc010pwe.1_Missense_Mutation_p.C184Y|TSNAX-DISC1_uc010pwf.1_Missense_Mutation_p.C184Y|TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.C218Y|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.C184Y|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.C184Y|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.C218Y|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.C218Y|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwo.1_Missense_Mutation_p.C229Y|DISC1_uc010pwp.1_Missense_Mutation_p.C229Y|DISC1_uc010pwq.1_Missense_Mutation_p.C229Y|DISC1_uc010pwr.1_Missense_Mutation_p.C229Y|DISC1_uc010pws.1_Missense_Mutation_p.C229Y|DISC1_uc010pwt.1_Missense_Mutation_p.C229Y|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.C229Y|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.C229Y|DISC1_uc010pxb.1_Missense_Mutation_p.C229Y|DISC1_uc010pxc.1_Missense_Mutation_p.C229Y|DISC1_uc010pxd.1_5'UTR|DISC1_uc010pxe.1_Missense_Mutation_p.C229Y|DISC1_uc009xfr.2_Missense_Mutation_p.C184Y|DISC1_uc010pxf.1_Missense_Mutation_p.C229Y|DISC1_uc010pxg.1_Missense_Mutation_p.C229Y|DISC1_uc010pxh.1_Missense_Mutation_p.C229Y|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_5'UTR|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.C229Y|DISC1_uc010pxn.1_5'UTR|DISC1_uc001hva.2_Missense_Mutation_p.C229Y|DISC1_uc010pwm.1_Missense_Mutation_p.C229Y|DISC1_uc001hux.1_Missense_Mutation_p.C229Y|DISC1_uc001hvc.3_Missense_Mutation_p.C229Y|DISC1_uc010pwn.1_Missense_Mutation_p.C229Y	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	229	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				GCAGAAGGCTGCCCACCATCC	0.617													9	58					0	0	0	0	A	231830190	A	A	231830190	3	1	160	1	0	0	0	0	1	0	0	0	4560	1319	46	4	692	4	DISC1	1	231830190	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	4529710	231830190	17420431	19	29053											
KIF26B	55083	broad.mit.edu	37	chr1	245850124	245850124	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagacgctcttccatcagctCctggctgagcgagatgagcg	8	8	12	13	3	2	4	1	2	1	2	4	5	4	4	2	1	3	3	2	1	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr1:245850124C>T	uc001ibf.1	+	12	4279	c.3839C>T	c.(3838-3840)TCC>TTC	p.S1280F	KIF26B_uc001ibg.1_Missense_Mutation_p.S898F|KIF26B_uc001ibh.1_Missense_Mutation_p.S522F	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1280					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			TCCATCAGCTCCTGGCTGAGC	0.612													4	36					0	0	0	0	T	245850124	T	T	245850124	3	4	160	1	0	0	0	0	1	0	0	0	8334	855	30	2	3885	2	KIF26B	1	245850124	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	14019934	245850124	3400497	20	29054											
CNGA3	1261	broad.mit.edu	37	chr2	99013345	99013345	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacggccaacatccgcagcaTtggctactcagacctgttct	9	9	9	14	2	2	1	1	0	1	1	3	2	3	1	3	2	3	4	3	2	2	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:99013345T>C	uc002syt.2	+	8	2129	c.1712T>C	c.(1711-1713)ATT>ACT	p.I571T	CNGA3_uc002syu.2_Missense_Mutation_p.I553T|CNGA3_uc010fij.2_Missense_Mutation_p.I575T	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	571	cGMP.				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						ATCCGCAGCATTGGCTACTCA	0.587													19	134					0	0	0	0	C	99013345	C	C	99013345	3	2	160	1	0	0	0	0	1	0	0	0	3613	1493	52	5	1738	5	CNGA3	2	99013345	Missense_Mutation	SNP	T	TCGA-CR-7394-01A-11D-2012-08		99013345	144186028	21	29055											
UBXN4	23190	broad.mit.edu	37	chr2	136536546	136536546	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caacacttacggtaatttttCgttagcaaccatgtttccca	11	14	5	11	2	0	0	0	0	0	0	2	0	1	0	2	1	4	4	2	1	5	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:136536546C>T	uc002tur.2	+	11	1393	c.1082C>T	c.(1081-1083)TCG>TTG	p.S361L	UBXN4_uc002tus.2_Missense_Mutation_p.S127L|UBXN4_uc002tut.2_5'UTR	NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	361	UBX.|Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						GGTAATTTTTCGTTAGCAACC	0.358													7	60					0	0	0	0	T	136536546	T	T	136536546	3	4	160	1	0	0	0	0	1	0	0	0	16984	893	31	1	1124	1	UBXN4	2	136536546	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	37523201	136536546	106662827	22	29056											
ITGA6	3655	broad.mit.edu	37	chr2	173355777	173355777	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacaactcaagaaagaaacGggaaattactgaaaaacaga	22	5	7	7	1	2	4	2	1	0	3	2	5	2	5	0	1	4	0	0	1	8	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:173355777G>A	uc002uhp.1	+	21	2908	c.2705G>A	c.(2704-2706)CGG>CAG	p.R902Q	ITGA6_uc010zdy.1_Missense_Mutation_p.R783Q|ITGA6_uc002uho.1_Missense_Mutation_p.R902Q|ITGA6_uc010fqm.1_Missense_Mutation_p.R533Q	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	941	Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			AGAAAGAAACGGGAAATTACT	0.299													18	167					0	0	0	0	A	173355777	A	A	173355777	3	1	160	1	0	0	0	0	1	0	0	0	7919	1116	39	1	2787	1	ITGA6	2	173355777	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	36819231	173355777	69843596	23	29057											
NAB1	4664	broad.mit.edu	37	chr2	191524148	191524148	+	Silent	SNP	C	T	T																															gtcacaaaccctgggcttttCaatcagccactgacttccct																										TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:191524148C>T	uc002usb.2	+	4	818	c.246C>T	c.(244-246)TTC>TTT	p.F82F	NAB1_uc010fsc.2_Silent_p.F82F|NAB1_uc010fsd.2_Silent_p.F82F|NAB1_uc002usc.2_Silent_p.F82F|NAB1_uc010zgh.1_Silent_p.F82F	NM_005966	NP_005957	Q13506	NAB1_HUMAN	NGFI-A binding protein 1	82	NCD1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			CTGGGCTTTTCAATCAGCCAC	0.478													4	80					0	0	0	0	T	191524148	T	T	191524148	2	4	160	1	0	0	0	0	0	0	0	1	10184	825	29	2		2	NAB1	2	191524148	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	18168371	191524148	51675225	24	29058	57	2									
NAB1	4664	broad.mit.edu	37	chr2	191524152	191524152	+	Missense_Mutation	SNP	C	G	G																															caaaccctgggcttttcaatCagccactgacttcccttcct																										TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:191524152C>G	uc002usb.2	+	4	822	c.250C>G	c.(250-252)CAG>GAG	p.Q84E	NAB1_uc010fsc.2_Missense_Mutation_p.Q84E|NAB1_uc010fsd.2_Missense_Mutation_p.Q84E|NAB1_uc002usc.2_Missense_Mutation_p.Q84E|NAB1_uc010zgh.1_Missense_Mutation_p.Q84E	NM_005966	NP_005957	Q13506	NAB1_HUMAN	NGFI-A binding protein 1	84					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			GCTTTTCAATCAGCCACTGAC	0.493													4	82					0	0	0	0	G	191524152	G	G	191524152	3	3	160	1	0	0	0	0	1	0	0	0	10184	827	29	2	252	2	NAB1	2	191524152	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	4	191524152	51675221	25	29059	57	2									
SF3B1	23451	broad.mit.edu	37	chr2	198299715	198299715	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttcgtgagtcttggcgatCttcgccattttgtccactcg	4	15	9	13	4	2	1	0	1	2	0	6	2	3	1	3	1	0	0	3	1	0	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:198299715C>T	uc002uue.2	-	1	57	c.9G>A	c.(7-9)AAG>AAA	p.K3K	SF3B1_uc010fsk.1_RNA|SF3B1_uc002uuf.2_Silent_p.K3K|SF3B1_uc002uug.2_Silent_p.K3K	NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	3					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCTTGGCGATCTTCGCCATTT	0.517													5	62					0	0	0	0	T	198299715	T	T	198299715	2	4	160	1	0	0	0	0	0	0	0	1	14214	912	32	2		2	SF3B1	2	198299715	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	6775563	198299715	44899658	26	29060											
CASP8	841	broad.mit.edu	37	chr2	202137620	202137620	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtttccccttttaattcaGagagaagcagcagccttgaa	11	11	10	9	0	1	3	1	1	0	2	2	4	2	3	3	1	3	3	3	1	3	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:202137620G>C	uc002uxr.1	+	6	760	c.551_splice	c.e6-1	p.E184_splice	CASP8_uc010ftc.1_3'UTR|CASP8_uc002uxo.1_Splice_Site_p.E184_splice|CASP8_uc002uxp.1_Intron|CASP8_uc002uxq.1_Intron|CASP8_uc002uxt.1_Splice_Site_p.E243_splice|CASP8_uc002uxu.1_Splice_Site|CASP8_uc002uxv.1_Intron|CASP8_uc002uxw.1_Intron|CASP8_uc002uxy.1_Splice_Site_p.E184_splice|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Intron|CASP8_uc010fte.1_Intron	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor						activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TTTTAATTCAGAGAGAAGCAG	0.368										HNSCC(4;0.00038)			4	80					0	0	0	0	C	202137620	C	C	202137620	5	2	160	1	0	0	0	0	0	0	1	0	2689	956	33	2	845	2	CASP8	2	202137620	Splice_Site	SNP	G	TCGA-CR-7394-01A-11D-2012-08	3837905	202137620	41061753	27	29061											
STRADB	55437	broad.mit.edu	37	chr2	202340452	202340452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaactatctgcaccaaaatGgctgtattcacaggtattta	13	13	7	8	0	2	1	1	1	1	0	2	1	2	1	1	2	2	4	1	2	7	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:202340452G>A	uc002uyd.3	+	7	900	c.535G>A	c.(535-537)GGC>AGC	p.G179S		NM_018571	NP_061041	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta	179	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			skin(2)|stomach(1)|lung(1)	4						GCACCAAAATGGCTGTATTCA	0.338													18	90					0	0	0	0	A	202340452	A	A	202340452	3	1	160	1	0	0	0	0	1	0	0	0	15391	1348	47	4	557	4	STRADB	2	202340452	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	202832	202340452	40858921	28	29062											
DYTN	391475	broad.mit.edu	37	chr2	207530693	207530693	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcgacaaattctttcttcCtgggaggtgtatatagcttg	10	15	9	7	1	2	0	0	0	2	0	4	2	3	1	1	2	1	2	1	2	5	7			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:207530693C>T	uc002vbr.1	-	10	1158	c.1041G>A	c.(1039-1041)CAG>CAA	p.Q347Q		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	347	Potential.					plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TTCTTTCTTCCTGGGAGGTGT	0.408													10	74					0	0	0	0	T	207530693	T	T	207530693	2	4	160	1	0	0	0	0	0	0	0	1	4883	680	24	4		4	DYTN	2	207530693	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	5190241	207530693	35668680	29	29063											
ERBB4	2066	broad.mit.edu	37	chr2	212530201	212530201	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actttgtacagttgtcaggaCcctgaaatgtgaaaacgaaa	15	10	9	7	1	1	2	1	2	0	0	1	4	1	3	1	1	2	2	1	1	5	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:212530201C>T	uc002veg.1	-	15	1816	c.1718G>A	c.(1717-1719)GGT>GAT	p.G573D	ERBB4_uc002veh.1_Missense_Mutation_p.G573D|ERBB4_uc010zji.1_Missense_Mutation_p.G573D|ERBB4_uc010zjj.1_Missense_Mutation_p.G573D|ERBB4_uc010fut.1_Missense_Mutation_p.G573D	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	573	Extracellular (Potential).|Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTTGTCAGGACCCTGAAATGT	0.393										TSP Lung(8;0.080)			4	47					0	0	0	0	T	212530201	T	T	212530201	3	4	160	1	0	0	0	0	1	0	0	0	5233	521	18	4	2264	4	ERBB4	2	212530201	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	4999508	212530201	30669172	30	29064											
SPEG	10290	broad.mit.edu	37	chr2	220355164	220355164	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgtgcgagcgtgccgggaGaatgccacggggcgaacgtt	7	7	18	9	6	0	1	0	0	0	1	0	4	0	1	2	3	5	2	2	3	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr2:220355164G>A	uc010fwg.2	+	37	8955	c.8955G>A	c.(8953-8955)GAG>GAA	p.E2985E		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2985	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CGTGCCGGGAGAATGCCACGG	0.672													8	59					0	0	0	0	A	220355164	A	A	220355164	2	1	160	1	0	0	0	0	0	0	0	1	15102	933	33	2		2	SPEG	2	220355164	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	7824963	220355164	22844209	31	29065											
CRBN	51185	broad.mit.edu	37	chr3	3215782	3215782	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggttctatctttctgaattAaattccgcaccatactgact	11	15	5	10	1	3	2	0	2	3	0	4	2	4	2	2	1	1	2	2	1	5	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr3:3215782A>G	uc003bpq.2	-	3	357	c.338T>C	c.(337-339)TTA>TCA	p.L113S	CRBN_uc003bpr.2_Missense_Mutation_p.L112S|CRBN_uc010hbw.2_Missense_Mutation_p.L113S|CRBN_uc011aso.1_Missense_Mutation_p.L50S	NM_016302	NP_057386	Q96SW2	CRBN_HUMAN	cereblon	113	Lon.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul4A-RING ubiquitin ligase complex|cytoplasm|membrane|nucleus	ATP-dependent peptidase activity|protein binding			ovary(1)	1				Epithelial(13;0.00244)|OV - Ovarian serous cystadenocarcinoma(96;0.00617)|all cancers(10;0.0079)		TTTCTGAATTAAATTCCGCAC	0.408													4	54					0	0	0	0	G	3215782	G	G	3215782	3	3	160	1	0	0	0	0	1	0	0	0	3866	372	13	5	1026	5	CRBN	3	3215782	Missense_Mutation	SNP	A	TCGA-CR-7394-01A-11D-2012-08		3215782	194806648	32	29066											
DLEC1	9940	broad.mit.edu	37	chr3	38081059	38081059	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcatcggcgacgaagtgagcGcaagcttgatcaaggcccgc	10	6	13	12	5	2	2	2	2	0	0	3	4	2	2	1	2	2	2	1	2	3	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr3:38081059G>A	uc003cho.1	+	1	364	c.343G>A	c.(343-345)GCA>ACA	p.A115T	DLEC1_uc003chp.1_Missense_Mutation_p.A115T|DLEC1_uc010hgv.1_Missense_Mutation_p.A115T	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	115					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CGAAGTGAGCGCAAGCTTGAT	0.642													4	114					0	0	0	0	A	38081059	A	A	38081059	3	1	160	1	0	0	0	0	1	0	0	0	4574	1087	38	1	345	1	DLEC1	3	38081059	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	34865277	38081059	159941371	33	29067											
SNRK	54861	broad.mit.edu	37	chr3	43381993	43381993	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcgagacgccattgtagagTacgtcaatgcccgtcagtac	11	9	10	11	4	2	2	2	0	0	2	3	3	2	2	2	0	3	3	2	0	4	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr3:43381993T>C	uc003cms.3	+	5	1276	c.944_splice	c.e5+2	p.E315_splice	SNRK_uc003cmt.3_Splice_Site_p.E315_splice|SNRK_uc010hik.2_Splice_Site_p.E315_splice|SNRK_uc011azr.1_Splice_Site_p.E109_splice	NM_017719	NP_060189	Q9NRH2	SNRK_HUMAN	SNF related kinase						myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		CATTGTAGAGTACGTCAATGC	0.488													5	38					0	0	0	0	C	43381993	C	C	43381993	5	2	160	1	0	0	0	0	0	0	1	0	14915	1652	57	5	956	5	SNRK	3	43381993	Splice_Site	SNP	T	TCGA-CR-7394-01A-11D-2012-08	5300934	43381993	154640437	34	29068											
COL7A1	1294	broad.mit.edu	37	chr3	48629337	48629337	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccccgcactgaccagtctCacgccgccattccaaccggt	7	7	7	20	4	1	1	1	1	1	0	4	1	3	1	7	1	1	1	7	1	1	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr3:48629337C>G	uc003ctz.2	-	10	1352	c.1351G>C	c.(1351-1353)GAG>CAG	p.E451Q		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	451	Nonhelical region (NC1).|Fibronectin type-III 3.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGACCAGTCTCACGCCGCCAT	0.632													14	105					0	0	0	0	G	48629337	G	G	48629337	3	3	160	1	0	0	0	0	1	0	0	0	3719	835	29	2	7919	2	COL7A1	3	48629337	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	5247344	48629337	149393093	35	29069											
SLMAP	7871	broad.mit.edu	37	chr3	57875802	57875802	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagggcatctaaccaaagcGgtagaagaaacaaagctttc	17	6	10	8	1	1	2	0	0	1	2	2	3	1	2	1	2	4	3	1	2	7	3	rs148417939		TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr3:57875802G>A	uc003dje.1	+	13	1489	c.1284G>A	c.(1282-1284)GCG>GCA	p.A428A	SLMAP_uc003djc.1_Silent_p.A424A|SLMAP_uc003djd.1_Silent_p.A411A|SLMAP_uc003djf.1_Silent_p.A390A|SLMAP_uc003djg.1_Intron|SLMAP_uc011bez.1_5'UTR|SLMAP_uc011bfa.1_5'UTR|SLMAP_uc003djh.2_5'UTR|SLMAP_uc003dji.1_5'UTR	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	428	Cytoplasmic (Potential).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		TAACCAAAGCGGTAGAAGAAA	0.393													3	51					0	0	0	0	A	57875802	A	A	57875802	2	1	160	1	0	0	0	0	0	0	0	1	14813	1103	39	1		1	SLMAP	3	57875802	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	9246465	57875802	140146628	36	29070											
ALCAM	214	broad.mit.edu	37	chr3	105253681	105253681	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgaacaggcagtatttgAtatttactgtaagtaattca	13	16	7	5	0	2	2	1	2	1	0	2	2	2	2	0	1	2	4	0	1	6	9			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr3:105253681A>G	uc003dvx.2	+	6	1262	c.722A>G	c.(721-723)GAT>GGT	p.D241G	ALCAM_uc003dvw.1_Missense_Mutation_p.D241G|ALCAM_uc003dvy.2_Missense_Mutation_p.D241G|ALCAM_uc011bhh.1_Missense_Mutation_p.D190G|ALCAM_uc010hpp.2_Missense_Mutation_p.D50G	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	241	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						GCAGTATTTGATATTTACTGT	0.323													6	31					0	0	0	0	G	105253681	G	G	105253681	3	3	160	1	0	0	0	0	1	0	0	0	487	333	12	5	744	5	ALCAM	3	105253681	Missense_Mutation	SNP	A	TCGA-CR-7394-01A-11D-2012-08	47377879	105253681	92768749	37	29071											
STXBP5L	9515	broad.mit.edu	37	chr3	120977900	120977900	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcttaaagtgtgaagacaCggccagtgcgaatgcctcca	11	9	11	10	2	1	2	0	1	1	1	2	3	2	2	3	1	2	1	3	1	4	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr3:120977900C>T	uc003eec.3	+	18	1983	c.1843C>T	c.(1843-1845)CGG>TGG	p.R615W	STXBP5L_uc011bji.1_Missense_Mutation_p.R615W	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	615	WD 9.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		TGTGAAGACACGGCCAGTGCG	0.373													4	32					0	0	0	0	T	120977900	T	T	120977900	3	4	160	1	0	0	0	0	1	0	0	0	15423	527	19	1	1909	1	STXBP5L	3	120977900	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	15724219	120977900	77044530	38	29072											
PIK3CA	5290	broad.mit.edu	37	chr3	178938934	178938934	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaacaggagaagaaggatGaaacacaaaaggtgtgtgac	19	5	12	5	0	1	4	1	2	0	2	1	6	1	5	0	3	2	0	0	3	6	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr3:178938934G>A	uc003fjk.2	+	14	2333	c.2176G>A	c.(2176-2178)GAA>AAA	p.E726K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	726					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E726K(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAGAAGGATGAAACACAAAA	0.363		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	28					0	0	0	0	A	178938934	A	A	178938934	3	1	160	1	0	0	0	0	1	0	0	0	11968	1291	45	2	2226	2	PIK3CA	3	178938934	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	57961034	178938934	19083496	39	29073											
CEP135	9662	broad.mit.edu	37	chr4	56830508	56830508	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtggtcggtcccctgatgtCctttctctggagtctagaaa	6	13	12	10	1	2	2	0	1	2	1	6	3	4	3	3	4	0	0	3	4	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr4:56830508C>A	uc003hbi.2	+	7	1002	c.768C>A	c.(766-768)GTC>GTA	p.V256V	CEP135_uc003hbj.2_5'Flank|CEP135_uc010igz.1_Silent_p.V86V	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	256	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					CCCCTGATGTCCTTTCTCTGG	0.353													5	38					1.23904e-05	1.33275e-05	1	0	A	56830508	A	A	56830508	2	1	160	1	0	0	0	0	0	0	0	1	3262	842	30	2		2	CEP135	4	56830508	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08		56830508	134323768	40	29074											
UGT2B10	7365	broad.mit.edu	37	chr4	69885688	69885688	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaatcttgactcttgtagttTtttcataagtttcttatttg	9	22	5	5	0	4	1	1	1	3	0	4	1	4	1	0	0	0	3	0	0	4	10			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr4:69885688T>C	uc011cao.1	-	4	437	c.301A>G	c.(301-303)AAA>GAA	p.K101E	UGT2B10_uc011can.1_Missense_Mutation_p.K101E			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	138					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TCTTGTAGTTTTTTCATAAGT	0.333													5	35					0	0	0	0	C	69885688	C	C	69885688	3	2	160	1	0	0	0	0	1	0	0	0	17024	1841	64	5	2809	5	UGT2B10	4	69885688	Missense_Mutation	SNP	T	TCGA-CR-7394-01A-11D-2012-08	13055180	69885688	121268588	41	29075											
ENAM	10117	broad.mit.edu	37	chr4	71509145	71509145	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatgaagtctttcctggaCaaaatagatggggtgaagag	14	9	14	4	0	1	5	0	2	1	3	2	7	2	6	1	3	0	0	1	3	5	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr4:71509145C>T	uc011caw.1	+	9	2283	c.2002C>T	c.(2002-2004)CAA>TAA	p.Q668*		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	668					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			CTTTCCTGGACAAAATAGATG	0.443													9	74					0	0	0	0	T	71509145	T	T	71509145	4	4	160	1	0	0	0	0	0	1	0	0	5136	479	17	4	2032	4	ENAM	4	71509145	Nonsense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	1623457	71509145	119645131	42	29076											
NUP54	53371	broad.mit.edu	37	chr4	77057369	77057369	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaaagggattttcttgtgtGaattccactggcggaatatt	11	14	10	6	1	1	1	0	1	1	0	2	3	2	3	1	3	0	0	1	3	5	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr4:77057369G>A	uc003hjs.2	-	4	620	c.492C>T	c.(490-492)TTC>TTT	p.F164F	NUP54_uc010ije.2_Intron|NUP54_uc011cbs.1_Intron|NUP54_uc011cbt.1_Silent_p.F116F|NUP54_uc003hjt.2_Intron	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	164	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2						TTTCTTGTGTGAATTCCACTG	0.323													5	61					0	0	0	0	A	77057369	A	A	77057369	2	1	160	1	0	0	0	0	0	0	0	1	10821	1281	45	2		2	NUP54	4	77057369	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	5548224	77057369	114096907	43	29077											
NAP1L5	266812	broad.mit.edu	37	chr4	89618774	89618774	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgaccagccgcgctgtcAgggtcaccagccgcgctgtc	6	7	12	16	4	3	1	2	1	1	0	4	1	3	1	4	1	2	2	4	1	0	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr4:89618774A>G	uc003hrx.2	-	1	250	c.132T>C	c.(130-132)CCT>CCC	p.P44P	HERC3_uc003hrw.1_Intron|HERC3_uc011cdn.1_Intron|HERC3_uc011cdo.1_Intron	NM_153757	NP_715638	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	44					nucleosome assembly	nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		CCGCGCTGTCAGGGTCACCAg	0.343													3	109					0	0	0	0	G	89618774	G	G	89618774	2	3	160	1	0	0	0	0	0	0	0	1	10213	175	7	5		5	NAP1L5	4	89618774	Silent	SNP	A	TCGA-CR-7394-01A-11D-2012-08	12561405	89618774	101535502	44	29078											
PDLIM5	10611	broad.mit.edu	37	chr4	95497118	95497118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtcaccagcgtgtgttccGagacttctcaggagctagca	9	9	11	12	2	2	1	2	0	1	1	4	3	3	2	2	1	3	3	2	1	1	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr4:95497118G>A	uc003hti.2	+	5	794	c.643G>A	c.(643-645)GAG>AAG	p.E215K	PDLIM5_uc003htf.2_Intron|PDLIM5_uc003htg.2_Missense_Mutation_p.E106K|PDLIM5_uc011cdx.1_Missense_Mutation_p.E106K|PDLIM5_uc003hth.2_Missense_Mutation_p.E106K|PDLIM5_uc003htj.2_Intron|PDLIM5_uc003htk.2_Missense_Mutation_p.E106K|PDLIM5_uc011cdy.1_Missense_Mutation_p.E93K	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	215					regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		CGTGTGTTCCGAGACTTCTCA	0.512													11	60					0	0	0	0	A	95497118	A	A	95497118	3	1	160	1	0	0	0	0	1	0	0	0	11737	1059	37	1	657	1	PDLIM5	4	95497118	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	5878344	95497118	95657158	45	29079											
LRIT3	345193	broad.mit.edu	37	chr4	110791477	110791477	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgtattccaagtatggtggGaaggacctgctgctgttgaa	9	13	13	6	0	0	1	0	1	0	0	1	3	1	3	2	3	2	5	2	3	5	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr4:110791477G>T	uc003hzx.3	+	3	1630	c.1437G>T	c.(1435-1437)GGG>GGT	p.G479G	LRIT3_uc003hzw.3_Silent_p.G341G	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	479	Fibronectin type-III.					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		AGTATGGTGGGAAGGACCTGC	0.483													16	114					1.99824e-07	2.16758e-07	1	0	T	110791477	T	T	110791477	2	4	160	1	0	0	0	0	0	0	0	1	8999	1161	41	2		2	LRIT3	4	110791477	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	15294359	110791477	80362799	46	29080											
KIAA1109	84162	broad.mit.edu	37	chr4	123159467	123159467	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaccatttggttcaaaaagaGttcttgcatgggacaaaaag	15	10	10	6	0	2	1	1	0	1	1	2	3	2	2	1	2	1	3	1	2	4	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr4:123159467G>A	uc003ieh.2	+	26	3840	c.3795G>A	c.(3793-3795)GAG>GAA	p.E1265E	KIAA1109_uc003iei.1_Silent_p.E1018E|KIAA1109_uc010ins.1_Silent_p.E608E|KIAA1109_uc003iek.2_5'Flank	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1265					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTCAAAAAGAGTTCTTGCATG	0.388													8	60					0	0	0	0	A	123159467	A	A	123159467	2	1	160	1	0	0	0	0	0	0	0	1	8247	1020	36	4		4	KIAA1109	4	123159467	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	12367990	123159467	67994809	47	29081											
FAT1	2195	broad.mit.edu	37	chr4	187535344	187535344	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgtcccaaactccatcattaCctgtgtctggatttagtttg	8	16	7	10	0	2	0	1	0	1	0	4	1	4	1	3	1	2	1	3	1	3	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr4:187535344C>T	uc003izf.2	-	12	9417	c.9229_splice	c.e12+1	p.G3077_splice		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TCCATCATTACCTGTGTCTGG	0.368										HNSCC(5;0.00058)			36	108					0	0	0	0	T	187535344	T	T	187535344	5	4	160	1	0	0	0	0	0	0	1	0	5721	521	18	4	4600	4	FAT1	4	187535344	Splice_Site	SNP	C	TCGA-CR-7394-01A-11D-2012-08	64375877	187535344	3618932	48	29082											
SLC6A3	6531	broad.mit.edu	37	chr5	1416262	1416262	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctggagaaggcgatcagcaCcccgaaccccacgcccaggg	10	2	13	16	3	1	1	1	0	0	1	1	4	1	1	5	3	2	2	5	3	2	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:1416262C>A	uc003jck.2	-	7	1103	c.982G>T	c.(982-984)GTG>TTG	p.V328L		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	328	Helical; Name=6; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	GCGATCAGCACCCCGAACCCC	0.617													4	61					0.00909568	0.00946542	1	0	A	1416262	A	A	1416262	3	1	160	1	0	0	0	0	1	0	0	0	14749	507	18	4	916	4	SLC6A3	5	1416262	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08		1416262	179498998	49	29083											
MARCH6	10299	broad.mit.edu	37	chr5	10423860	10423860	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tccctaggactgggcacttgGagtcctgcatgccaaaatca	10	9	10	12	0	1	0	1	0	0	0	3	2	3	2	3	3	2	2	3	3	3	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:10423860G>C	uc003jet.1	+	23	2480	c.2297G>C	c.(2296-2298)GGA>GCA	p.G766A	MARCH6_uc011cmu.1_Missense_Mutation_p.G718A|MARCH6_uc003jeu.1_Missense_Mutation_p.G464A|MARCH6_uc011cmv.1_Missense_Mutation_p.G661A	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	766	Helical; (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						TGGGCACTTGGAGTCCTGCAT	0.358													3	25					0	0	0	0	C	10423860	C	C	10423860	3	2	160	1	0	0	0	0	1	0	0	0	9358	1174	41	2	2387	2	MARCH6	5	10423860	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	9007598	10423860	170491400	50	29084											
CTNND2	1501	broad.mit.edu	37	chr5	11346704	11346704	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgctggctgcctgtgcgctGcaaggggacggagtcgacac	6	7	17	11	3	0	0	0	0	0	0	1	3	0	2	1	4	4	4	1	4	1	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:11346704G>A	uc003jfa.1	-	9	1553	c.1408C>T	c.(1408-1410)CAG>TAG	p.Q470*	CTNND2_uc010itt.2_Nonsense_Mutation_p.Q379*|CTNND2_uc011cmy.1_Nonsense_Mutation_p.Q133*|CTNND2_uc011cmz.1_Nonsense_Mutation_p.Q37*|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Nonsense_Mutation_p.Q37*	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	470					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CCTGTGCGCTGCAAGGGGACG	0.607													7	58					0	0	0	0	A	11346704	A	A	11346704	4	1	160	1	0	0	0	0	0	1	0	0	4037	1328	46	4	2325	4	CTNND2	5	11346704	Nonsense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	922844	11346704	169568556	51	29085											
MAST4	375449	broad.mit.edu	37	chr5	66461496	66461496	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacgcttctggcagagagccGggggccaagcccagcactgc	8	4	14	15	2	1	1	0	0	1	1	1	2	1	1	3	3	4	3	3	3	1	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:66461496G>A	uc003jut.1	+	28	5990	c.5922G>A	c.(5920-5922)CCG>CCA	p.P1974P	MAST4_uc003juw.2_Silent_p.P1902P|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	2166	Pro-rich.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GCAGAGAGCCGGGGGCCAAGC	0.682													3	11					0	0	0	0	A	66461496	A	A	66461496	2	1	160	1	0	0	0	0	0	0	0	1	9380	1103	39	1		1	MAST4	5	66461496	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	55114792	66461496	114453764	52	29086											
CD180	4064	broad.mit.edu	37	chr5	66479817	66479817	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggatgagatgtcagagaagCggtgttcctgcaggttgagg	9	10	17	5	1	1	3	1	2	0	2	2	6	2	4	1	4	2	3	1	4	1	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:66479817C>T	uc003juy.2	-	3	1002	c.854G>A	c.(853-855)CGC>CAC	p.R285H		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	285	Extracellular (Potential).|LRR 8.				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		GTCAGAGAAGCGGTGTTCCTG	0.473													12	70					0	0	0	0	T	66479817	T	T	66479817	3	4	160	1	0	0	0	0	1	0	0	0	2987	768	27	1	1135	1	CD180	5	66479817	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	18321	66479817	114435443	53	29087											
CCDC125	202243	broad.mit.edu	37	chr5	68590675	68590675	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgctgccattctggcacaaGaacaggggttccctccgggc	8	8	12	13	1	1	1	0	0	1	1	3	1	3	1	3	4	3	3	3	4	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:68590675G>A	uc003jvv.1	-	8	912	c.869C>T	c.(868-870)TCT>TTT	p.S290F	CCDC125_uc003jvx.1_Missense_Mutation_p.S289F|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_Missense_Mutation_p.S165F	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	290						cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		TCTGGCACAAGAACAGGGGTT	0.463													14	171					0	0	0	0	A	68590675	A	A	68590675	3	1	160	1	0	0	0	0	1	0	0	0	2773	942	33	2	682	2	CCDC125	5	68590675	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	2110858	68590675	112324585	54	29088											
LNPEP	4012	broad.mit.edu	37	chr5	96314945	96314945	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttacatcctctagagccTgatgaggtggaatatgagcc	10	12	11	8	0	1	4	0	3	1	1	2	5	2	5	3	2	3	1	3	2	4	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:96314945T>C	uc003kmv.1	+	2	637	c.123T>C	c.(121-123)CCT>CCC	p.P41P	LNPEP_uc003kmw.1_Silent_p.P27P	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	41	Cytoplasmic (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		CTCTAGAGCCTGATGAGGTGG	0.502													3	111					0	0	0	0	C	96314945	C	C	96314945	2	2	160	1	0	0	0	0	0	0	0	1	8906	1567	55	5		5	LNPEP	5	96314945	Silent	SNP	T	TCGA-CR-7394-01A-11D-2012-08	27724270	96314945	84600315	55	29089											
RIOK2	55781	broad.mit.edu	37	chr5	96498921	96498921	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacgtttcaccttctgtttCaccagttcctggaaagattt	8	16	7	10	1	3	2	2	1	1	1	4	3	4	3	3	1	0	3	3	1	1	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:96498921C>T	uc003kmz.2	-	10	1613	c.1503G>A	c.(1501-1503)GTG>GTA	p.V501V		NM_018343	NP_060813	Q9BVS4	RIOK2_HUMAN	RIO kinase 2 isoform 1	501	Protein kinase.						ATP binding|protein serine/threonine kinase activity			kidney(1)	1		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		CCTTCTGTTTCACCAGTTCCT	0.353													4	41					0	0	0	0	T	96498921	T	T	96498921	2	4	160	1	0	0	0	0	0	0	0	1	13443	813	29	2		2	RIOK2	5	96498921	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	183976	96498921	84416339	56	29090											
GFRA3	2676	broad.mit.edu	37	chr5	137593489	137593489	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggccctgcgcgtggggctcGgcggccttctcgaagaaagt	6	7	16	12	5	1	1	0	0	1	1	3	2	1	1	2	5	1	1	2	5	2	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:137593489G>A	uc003lcn.2	-	4	764	c.624C>T	c.(622-624)GCC>GCT	p.A208A	GFRA3_uc003lco.2_Silent_p.A177A	NM_001496	NP_001487	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3 preproprotein	208					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CGTGGGGCTCGGCGGCCTTCT	0.726													10	56					0	0	0	0	A	137593489	A	A	137593489	2	1	160	1	0	0	0	0	0	0	0	1	6386	1103	39	1		1	GFRA3	5	137593489	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	41094568	137593489	43321771	57	29091											
PCDHB9	56127	broad.mit.edu	37	chr5	140569021	140569021	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcggtgctcctgttcgtggcGgtgcggctgtgcaggaggag	3	10	19	9	4	0	0	0	0	0	0	3	2	1	2	1	6	3	4	1	6	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:140569021G>A	uc003liw.1	+	3	2130	c.2130G>A	c.(2128-2130)GCG>GCA	p.A710A	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	710	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTTCGTGGCGGTGCGGCTGT	0.697													26	234					0	0	0	0	A	140569021	A	A	140569021	2	1	160	1	0	0	0	0	0	0	0	1	11603	1116	39	1		1	PCDHB9	5	140569021	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	2975532	140569021	40346239	58	29092											
PCDHGA7	56108	broad.mit.edu	37	chr5	140764270	140764270	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaagattcaggccagaacGcctggctgtcatacctcctg	11	8	9	13	1	2	2	2	0	0	2	3	2	3	2	4	2	2	1	4	2	3	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:140764270G>T	uc003lka.1	+	1	1804	c.1804G>T	c.(1804-1806)GCC>TCC	p.A602S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.A602S	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	602	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCCAGAACGCCTGGCTGTC	0.642													11	118					1.5842e-08	1.72577e-08	1	0	T	140764270	T	T	140764270	3	4	160	1	0	0	0	0	1	0	0	0	11613	1087	38	3	1806	3	PCDHGA7	5	140764270	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	195249	140764270	40150990	59	29093											
DPYSL3	1809	broad.mit.edu	37	chr5	146804509	146804509	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgacgattctgcctcccttGataaggagacggtcactcta	9	12	9	11	2	3	3	1	2	2	1	4	5	4	3	2	2	1	0	2	2	2	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:146804509G>C	uc003lon.1	-	2	167	c.57C>G	c.(55-57)ATC>ATG	p.I19M	DPYSL3_uc003loo.2_Missense_Mutation_p.I133M	NM_001387	NP_001378	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	19					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCTCCCTTGATAAGGAGAC	0.368													6	64					0	0	0	0	C	146804509	C	C	146804509	3	2	160	1	0	0	0	0	1	0	0	0	4770	1280	45	2	1707	2	DPYSL3	5	146804509	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	6040239	146804509	34110751	60	29094											
HK3	3101	broad.mit.edu	37	chr5	176310832	176310832	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggacatcatggtccccacCgtgtcattgacaatggcaac	11	8	9	13	1	2	1	2	1	0	0	3	2	3	2	3	3	1	1	3	3	2	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr5:176310832C>T	uc003mfa.2	-	15	2084	c.1992G>A	c.(1990-1992)ACG>ACA	p.T664T	HK3_uc003mez.2_Silent_p.T220T	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	664	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGTCCCCACCGTGTCATTGA	0.582													11	123					0	0	0	0	T	176310832	T	T	176310832	2	4	160	1	0	0	0	0	0	0	0	1	7231	639	23	1		1	HK3	5	176310832	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	29506323	176310832	4604428	61	29095											
HFE	3077	broad.mit.edu	37	chr6	26093372	26093372	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaccgtctggcaccctagtCattggagtcatcagtggaat	9	11	10	11	1	5	0	4	0	1	0	5	2	5	2	2	3	0	1	2	3	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr6:26093372C>T	uc003nfx.1	+	5	1078	c.918C>T	c.(916-918)GTC>GTT	p.V306V	HFE_uc003nfy.1_Silent_p.V283V|HFE_uc010jqe.1_Silent_p.V303V|HFE_uc003nfz.1_Silent_p.V218V|HFE_uc003ngd.1_Silent_p.V204V|HFE_uc003nga.1_Silent_p.V292V|HFE_uc003ngb.1_Silent_p.V200V|HFE_uc003ngc.1_Silent_p.V214V|HFE_uc003nge.1_Silent_p.V126V|HFE_uc003ngf.1_Silent_p.V34V	NM_000410	NP_000401	Q30201	HFE_HUMAN	hemochromatosis protein isoform 1 precursor	306	Connecting peptide.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|cellular iron ion homeostasis|immune response|iron ion transport|protein complex assembly|receptor-mediated endocytosis	apical part of cell|basal part of cell|cytoplasmic vesicle|early endosome|integral to plasma membrane|MHC class I protein complex|perinuclear region of cytoplasm|recycling endosome	protein binding				0						GCACCCTAGTCATTGGAGTCA	0.443									Hemochromatosis				5	46					0	0	0	0	T	26093372	T	T	26093372	2	4	160	1	0	0	0	0	0	0	0	1	7120	813	29	2		2	HFE	6	26093372	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08		26093372	145021695	62	29096											
HIST1H2BH	8345	broad.mit.edu	37	chr6	26252218	26252218	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tggccaagcacgccgtgtccGagggcactaaggccgtcacc	8	5	13	15	4	1	0	1	0	0	0	2	1	2	0	5	3	1	2	5	3	2	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr6:26252218G>C	uc003nhh.2	+	1	340	c.340G>C	c.(340-342)GAG>CAG	p.E114Q	HIST1H3F_uc003nhg.1_5'Flank	NM_003524	NP_003515	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	114					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)	3						CGCCGTGTCCGAGGGCACTAA	0.537													4	87					0	0	0	0	C	26252218	C	C	26252218	3	2	160	1	0	0	0	0	1	0	0	0	7186	1059	37	3	342	3	HIST1H2BH	6	26252218	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	158846	26252218	144862849	63	29097											
SLC29A1	2030	broad.mit.edu	37	chr6	44201176	44201176	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtgaagccagctgaggcaGagaccgcaggagccatcatg	13	4	14	10	1	1	3	1	2	0	1	1	5	1	4	3	2	3	3	3	2	2	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr6:44201176G>C	uc003owu.1	+	13	1611	c.1282G>C	c.(1282-1284)GAG>CAG	p.E428Q	SLC29A1_uc003owv.1_Missense_Mutation_p.E428Q|SLC29A1_uc003oww.1_Missense_Mutation_p.E507Q|SLC29A1_uc003owx.1_Missense_Mutation_p.E428Q|SLC29A1_uc003owy.1_Missense_Mutation_p.E428Q|SLC29A1_uc003owz.1_Missense_Mutation_p.E428Q	NM_004955	NP_004946	Q99808	S29A1_HUMAN	equilibrative nucleoside transporter 1	428	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			large_intestine(2)|skin(1)	3	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	AGCTGAGGCAGAGACCGCAGG	0.587													10	154					0	0	0	0	C	44201176	C	C	44201176	3	2	160	1	0	0	0	0	1	0	0	0	14598	943	33	2	1328	2	SLC29A1	6	44201176	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	17948958	44201176	126913891	64	29098											
RUNX2	860	broad.mit.edu	37	chr6	45480007	45480007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcaggcacagtcttcccCgccgtggtcctatgaccagt	7	8	11	15	2	1	1	0	1	1	0	3	1	3	1	5	3	0	2	5	3	1	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr6:45480007C>T	uc011dvx.1	+	7	1094	c.884C>T	c.(883-885)CCG>CTG	p.P295L	RUNX2_uc011dvy.1_Missense_Mutation_p.P295L|RUNX2_uc003oxt.2_Missense_Mutation_p.P281L	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	295	Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						CAGTCTTCCCCGCCGTGGTCC	0.532													8	95					0	0	0	0	T	45480007	T	T	45480007	3	4	160	1	0	0	0	0	1	0	0	0	13813	652	23	1	922	1	RUNX2	6	45480007	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	1278831	45480007	125635060	65	29099											
THEMIS	387357	broad.mit.edu	37	chr6	128134839	128134839	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttctgaagctaagattcttGatgcctggtactttttgtgg	7	18	10	6	0	2	3	0	2	2	1	2	3	2	3	1	2	3	2	1	2	3	7			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr6:128134839G>A	uc003qbi.2	-	5	1266	c.947C>T	c.(946-948)TCA>TTA	p.S316L	THEMIS_uc010kfa.2_Missense_Mutation_p.S219L|THEMIS_uc011ebt.1_Missense_Mutation_p.S316L|THEMIS_uc010kfb.2_Missense_Mutation_p.S281L	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	316	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TAAGATTCTTGATGCCTGGTA	0.438													4	115					0	0	0	0	A	128134839	A	A	128134839	3	1	160	1	0	0	0	0	1	0	0	0	15926	1294	45	2	1111	2	THEMIS	6	128134839	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	82654832	128134839	42980228	66	29100											
ENPP1	5167	broad.mit.edu	37	chr6	132201070	132201070	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggaagacctagagttctcCagaaggaaaacaccatctgt	15	8	9	9	0	2	3	0	0	2	3	3	5	2	5	3	2	1	1	3	2	5	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr6:132201070C>T	uc011ecf.1	+	20	2016	c.1996C>T	c.(1996-1998)CAG>TAG	p.Q666*		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	666	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TAGAGTTCTCCAGAAGGAAAA	0.403													9	80					0	0	0	0	T	132201070	T	T	132201070	4	4	160	1	0	0	0	0	0	1	0	0	5153	595	21	4	2074	4	ENPP1	6	132201070	Nonsense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	4066231	132201070	38913997	67	29101											
SYNE1	23345	broad.mit.edu	37	chr6	152772295	152772295	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaacctattcttctccacatCaatcttcagatgaagcaaat	14	12	4	11	0	5	2	2	1	3	1	6	3	5	2	2	0	2	1	2	0	5	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr6:152772295C>G	uc010kiw.2	-	26	3675	c.3073G>C	c.(3073-3075)GAT>CAT	p.D1025H	SYNE1_uc003qot.3_Missense_Mutation_p.D1032H|SYNE1_uc003qou.3_Missense_Mutation_p.D1025H|SYNE1_uc010kjb.1_Missense_Mutation_p.D1008H|SYNE1_uc003qow.2_Missense_Mutation_p.D320H|SYNE1_uc003qox.1_Missense_Mutation_p.D541H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1025	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCTCCACATCAATCTTCAGA	0.413										HNSCC(10;0.0054)			6	89					0	0	0	0	G	152772295	G	G	152772295	3	3	160	1	0	0	0	0	1	0	0	0	15511	826	29	2	23877	2	SYNE1	6	152772295	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	20571225	152772295	18342772	68	29102											
ARID1B	57492	broad.mit.edu	37	chr6	157256619	157256619	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggacatgtctcaggaaggctAtggaactagatctcaacctc	12	9	10	10	0	2	1	2	0	2	1	5	4	2	4	1	4	2	1	1	4	5	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr6:157256619A>G	uc003qqn.2	+	4	1885	c.1733A>G	c.(1732-1734)TAT>TGT	p.Y578C	ARID1B_uc003qqo.2_Missense_Mutation_p.Y591C|ARID1B_uc003qqp.2_Missense_Mutation_p.Y578C|ARID1B_uc003qqq.1_Missense_Mutation_p.Y6C	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	636					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CAGGAAGGCTATGGAACTAGA	0.363													13	92					0	0	0	0	G	157256619	G	G	157256619	3	3	160	1	0	0	0	0	1	0	0	0	914	449	16	5	1964	5	ARID1B	6	157256619	Missense_Mutation	SNP	A	TCGA-CR-7394-01A-11D-2012-08	4484324	157256619	13858448	69	29103											
MEOX2	4223	broad.mit.edu	37	chr7	15725557	15725557	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcttcgcttctccgcctcCgcaggtgacagtgcctggcg	3	9	12	17	5	1	1	0	1	1	0	4	1	2	1	5	2	1	3	5	2	0	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr7:15725557C>T	uc003stc.2	-	1	752	c.471G>A	c.(469-471)GCG>GCA	p.A157A	MEOX2_uc011jxw.1_Silent_p.A157A	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	157					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TCTCCGCCTCCGCAGGTGACA	0.711													15	200					0	0	0	0	T	15725557	T	T	15725557	2	4	160	1	0	0	0	0	0	0	0	1	9527	639	23	1		1	MEOX2	7	15725557	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08		15725557	143413106	70	29104											
DDC	1644	broad.mit.edu	37	chr7	50534944	50534944	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagacaagccccagaatgaCttccacacagatttcaaagc	15	6	7	13	0	1	4	1	1	0	3	2	4	2	4	3	0	2	1	3	0	3	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr7:50534944C>T	uc003tpf.3	-	13	1296	c.1210G>A	c.(1210-1212)GTC>ATC	p.V404I	DDC_uc010kza.2_Missense_Mutation_p.V319I|DDC_uc003tpg.3_Missense_Mutation_p.V404I	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	404					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CCCAGAATGACTTCCACACAG	0.448													20	128					0	0	0	0	T	50534944	T	T	50534944	3	4	160	1	0	0	0	0	1	0	0	0	4342	565	20	4	240	4	DDC	7	50534944	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	34809387	50534944	108603719	71	29105											
ZNF107	51427	broad.mit.edu	37	chr7	64168431	64168431	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagaacctctacaaatttgaAgaacatggaaaagcttttaa	18	10	7	6	0	1	3	0	1	1	2	1	5	1	4	1	1	4	1	1	1	8	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr7:64168431A>G	uc003ttd.2	+	7	2535	c.1749A>G	c.(1747-1749)GAA>GAG	p.E583E	ZNF107_uc003tte.2_Silent_p.E583E	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	583	C2H2-type 19; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				ACAAATTTGAAGAACATGGAA	0.338													3	77					0	0	0	0	G	64168431	G	G	64168431	2	3	160	1	0	0	0	0	0	0	0	1	17782	69	3	5		5	ZNF107	7	64168431	Silent	SNP	A	TCGA-CR-7394-01A-11D-2012-08	13633487	64168431	94970232	72	29106											
AP4M1	9179	broad.mit.edu	37	chr7	99701070	99701070	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accacatccacggagatgctGaggaatttcatccagacgga	13	7	10	11	2	1	3	1	1	0	2	3	6	3	5	3	3	1	1	3	3	1	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr7:99701070G>A	uc003utb.3	+	5	598	c.390G>A	c.(388-390)CTG>CTA	p.L130L	MCM7_uc003usv.1_5'Flank|MCM7_uc003usw.1_5'Flank|MCM7_uc003usx.1_5'Flank|AP4M1_uc011kjg.1_Intron|AP4M1_uc010lgl.1_Silent_p.L130L|AP4M1_uc003utc.3_Silent_p.L137L|AP4M1_uc010lgm.2_Silent_p.L2L|AP4M1_uc003utd.2_Silent_p.L130L|AP4M1_uc011kjh.1_Silent_p.L82L|AP4M1_uc003ute.3_5'UTR|AP4M1_uc003utf.3_Silent_p.L2L	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	130					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGGAGATGCTGAGGAATTTCA	0.537													8	70					0	0	0	0	A	99701070	A	A	99701070	2	1	160	1	0	0	0	0	0	0	0	1	753	1277	45	2		2	AP4M1	7	99701070	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	35532639	99701070	59437593	73	29107											
FAM71F1	84691	broad.mit.edu	37	chr7	128356921	128356921	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcttccaacaccatggccCtgggggtgacctcctcggta	8	8	11	14	1	0	1	0	1	0	0	3	1	2	1	5	4	2	2	5	4	3	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr7:128356921C>T	uc003vno.1	+	2	357	c.304C>T	c.(304-306)CTG>TTG	p.L102L	FAM71F1_uc010llo.1_Silent_p.L3L|FAM71F1_uc011koq.1_Missense_Mutation_p.P26L|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.P23L|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Silent_p.L102L	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	102										skin(1)	1						CACCATGGCCCTGGGGGTGAC	0.577													6	32					0	0	0	0	T	128356921	T	T	128356921	2	4	160	1	0	0	0	0	0	0	0	1	5644	680	24	4		4	FAM71F1	7	128356921	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	28655851	128356921	30781742	74	29108											
PLXNA4	91584	broad.mit.edu	37	chr7	131913119	131913119	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttaccagcacgttgtactGagagacggagatattgttgg	10	11	12	8	2	0	3	0	1	0	2	0	5	0	3	2	2	3	4	2	2	3	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr7:131913119G>A	uc003vra.3	-	6	1943	c.1714C>T	c.(1714-1716)CAG>TAG	p.Q572*		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	572	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						ACGTTGTACTGAGAGACGGAG	0.592													5	40					0	0	0	0	A	131913119	A	A	131913119	4	1	160	1	0	0	0	0	0	1	0	0	12177	1299	45	2	4078	2	PLXNA4	7	131913119	Nonsense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	3556198	131913119	27225544	75	29109											
ATP6V0A4	50617	broad.mit.edu	37	chr7	138455987	138455987	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcgcttcgaaacacagaCaccatcttggcccagcctcg	9	8	7	17	3	1	1	0	0	1	1	5	2	2	1	4	1	2	1	4	1	1	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr7:138455987C>T	uc003vuf.2	-	2	244	c.6G>A	c.(4-6)GTG>GTA	p.V2V	ATP6V0A4_uc003vug.2_Silent_p.V2V|ATP6V0A4_uc003vuh.2_Silent_p.V2V	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	2	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						GAAACACAGACACCATCTTGG	0.423													13	154					0	0	0	0	T	138455987	T	T	138455987	2	4	160	1	0	0	0	0	0	0	0	1	1172	465	17	4		4	ATP6V0A4	7	138455987	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	6542868	138455987	20682676	76	29110											
CUL1	8454	broad.mit.edu	37	chr7	148487477	148487477	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaattgacgtggttatatCagttgtctaaaggagaattg	14	13	11	3	1	2	2	1	1	1	1	2	4	2	2	0	2	0	2	0	2	7	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr7:148487477C>T	uc010lpg.2	+	16	2276	c.1750C>T	c.(1750-1752)CAG>TAG	p.Q584*	CUL1_uc003wey.2_Nonsense_Mutation_p.Q584*|CUL1_uc003wez.2_Nonsense_Mutation_p.Q474*|CUL1_uc003wfa.2_Nonsense_Mutation_p.Q245*	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	584					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GTGGTTATATCAGTTGTCTAA	0.358													5	59					0	0	0	0	T	148487477	T	T	148487477	4	4	160	1	0	0	0	0	0	1	0	0	4071	827	29	2	1808	2	CUL1	7	148487477	Nonsense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	10031490	148487477	10651186	77	29111											
C8orf79	57604	broad.mit.edu	37	chr8	12878806	12878806	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtttgttttaaagagcaGtgtggttcaaaacggtccca	10	14	10	7	1	2	1	1	0	1	1	3	1	3	1	1	2	2	4	1	2	4	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr8:12878806G>A	uc010lsq.2	+	5	1110	c.618G>A	c.(616-618)CAG>CAA	p.Q206Q	C8orf79_uc011kxw.1_Intron|C8orf79_uc003wwj.3_Silent_p.Q119Q|C8orf79_uc010lsr.2_Silent_p.Q80Q	NM_020844	NP_065895	Q9P272	K1456_HUMAN	hypothetical protein LOC57604 isoform 1	206							methyltransferase activity				0						TTAAAGAGCAGTGTGGTTCAA	0.478													12	106					0	0	0	0	A	12878806	A	A	12878806	2	1	160	1	0	0	0	0	0	0	0	1	2450	1020	36	4		4	C8orf79	8	12878806	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08		12878806	133485216	78	29112											
EXTL3	2137	broad.mit.edu	37	chr8	28573933	28573933	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagatcgaagcctgtaagaaGagcattgagaacgccaagca	17	5	11	8	2	0	4	0	1	0	4	1	6	0	4	2	0	4	3	2	0	6	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr8:28573933G>C	uc003xgz.1	+	3	950	c.357G>C	c.(355-357)AAG>AAC	p.K119N		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	119	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		CCTGTAAGAAGAGCATTGAGA	0.562													8	24					0	0	0	0	C	28573933	C	C	28573933	3	2	160	1	0	0	0	0	1	0	0	0	5352	933	33	2	359	2	EXTL3	8	28573933	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	15695127	28573933	117790089	79	29113											
RP1	6101	broad.mit.edu	37	chr8	55542326	55542326	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacacccatatttacttcagAcagacaaaaatgtgttcagg	15	11	6	9	0	2	2	2	0	0	2	2	2	2	2	1	1	2	1	1	1	5	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr8:55542326A>G	uc003xsd.1	+	4	6032	c.5884A>G	c.(5884-5886)ACA>GCA	p.T1962A	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1962					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTTACTTCAGACAGACAAAAA	0.318													5	44					0	0	0	0	G	55542326	G	G	55542326	3	3	160	1	0	0	0	0	1	0	0	0	13597	275	10	5	5894	5	RP1	8	55542326	Missense_Mutation	SNP	A	TCGA-CR-7394-01A-11D-2012-08	26968393	55542326	90821696	80	29114											
CSMD3	114788	broad.mit.edu	37	chr8	113662457	113662457	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaggggctcttcatgactCaacctgtatcctgaatcaca	12	10	8	11	0	4	3	3	2	1	1	5	3	5	3	2	2	1	2	2	2	4	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr8:113662457C>G	uc003ynu.2	-	19	3285	c.3126G>C	c.(3124-3126)TTG>TTC	p.L1042F	CSMD3_uc003yns.2_Missense_Mutation_p.L314F|CSMD3_uc003ynt.2_Missense_Mutation_p.L1002F|CSMD3_uc011lhx.1_Missense_Mutation_p.L938F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1042	Extracellular (Potential).|Sushi 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTCATGACTCAACCTGTATC	0.438										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			3	108					0	0	0	0	G	113662457	G	G	113662457	3	3	160	1	0	0	0	0	1	0	0	0	3963	825	29	2	8209	2	CSMD3	8	113662457	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	58120131	113662457	32701565	81	29115											
ZNF251	90987	broad.mit.edu	37	chr8	145947129	145947129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caacacgagtctgctgaggtGgtgtgagctgtgaactctgg	8	10	15	8	1	2	3	0	3	2	0	2	4	2	3	0	3	4	2	0	3	2	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr8:145947129G>A	uc003zdv.3	-	5	2172	c.1916C>T	c.(1915-1917)CCA>CTA	p.P639L		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	639	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		CTGCTGAGGTGGTGTGAGCTG	0.403													8	51					0	0	0	0	A	145947129	A	A	145947129	3	1	160	1	0	0	0	0	1	0	0	0	17863	1348	47	4	103	4	ZNF251	8	145947129	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	32284672	145947129	416893	82	29116											
CDKN2A	1029	broad.mit.edu	37	chr9	21971028	21971028	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggtccacgggcagacggccCcaggcatcgcgcacgtccag	8	3	14	16	5	0	1	0	0	0	1	3	1	2	1	4	4	0	3	4	4	0	0	rs121913389		TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr9:21971028C>T	uc003zpk.2	-	2	542	c.330G>A	c.(328-330)TGG>TGA	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.G166R	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGACGGCCCCAGGCATCGC	0.736		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			4	33					0	0	0	0	T	21971028	T	T	21971028	4	4	160	1	0	0	0	0	0	1	0	0	3176	624	22	4	148	4	CDKN2A	9	21971028	Nonsense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08		21971028	119242403	83	29117											
GALT	2592	broad.mit.edu	37	chr9	34647693	34647693	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttccaagcaaagtctgctcGaggagtctggtaactatgga	11	11	11	8	1	2	0	0	0	2	0	4	3	3	2	1	3	3	3	1	3	4	3	rs111033675		TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr9:34647693G>C	uc003zve.2	+	4	435	c.368G>C	c.(367-369)CGA>CCA	p.R123P	GALT_uc003zvf.2_Intron|GALT_uc003zvg.2_5'UTR|GALT_uc003zvh.2_Missense_Mutation_p.R75P|GALT_uc011lop.1_Missense_Mutation_p.R75P	NM_000155	NP_000146	P07902	GALT_HUMAN	galactose-1-phosphate uridylyltransferase	123			R -> G (in GALCT).|R -> Q (in GALCT).		galactose catabolic process	cytosol	UDP-glucose:hexose-1-phosphate uridylyltransferase activity|zinc ion binding				0	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		AAGTCTGCTCGAGGAGTCTGG	0.532									Galactosemia				5	48					0	0	0	0	C	34647693	C	C	34647693	3	2	160	1	0	0	0	0	1	0	0	0	6265	1058	37	3	382	3	GALT	9	34647693	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	12676665	34647693	106565738	84	29118											
CEP78	84131	broad.mit.edu	37	chr9	80858414	80858414	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcatgaagaaacctgggctGagagtcttcgctataggaga	12	8	14	7	1	1	4	0	2	1	3	2	6	1	4	1	3	1	3	1	3	4	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr9:80858414G>A	uc004akx.2	+	5	916	c.640G>A	c.(640-642)GAG>AAG	p.E214K	CEP78_uc004aky.3_Missense_Mutation_p.E214K|CEP78_uc010mpp.2_Missense_Mutation_p.E214K|CEP78_uc011lsp.1_Missense_Mutation_p.E127K	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	214					G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1						AACCTGGGCTGAGAGTCTTCG	0.403													7	49					0	0	0	0	A	80858414	A	A	80858414	3	1	160	1	0	0	0	0	1	0	0	0	3277	1291	45	2	658	2	CEP78	9	80858414	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	46210721	80858414	60355017	85	29119											
IARS	3376	broad.mit.edu	37	chr9	95013063	95013063	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaacagaaacagggtcaatCagcacctttagattctggta	14	10	9	8	0	3	3	2	1	1	2	3	3	3	3	1	2	3	2	1	2	5	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr9:95013063C>T	uc004art.1	-	23	2618	c.2361G>A	c.(2359-2361)CTG>CTA	p.L787L	IARS_uc004ars.1_Silent_p.L632L|IARS_uc004aru.3_Silent_p.L787L|IARS_uc010mqr.2_Silent_p.L677L|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	787					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	CAGGGTCAATCAGCACCTTTA	0.453													5	23					0	0	0	0	T	95013063	T	T	95013063	2	4	160	1	0	0	0	0	0	0	0	1	7512	813	29	2		2	IARS	9	95013063	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	14154649	95013063	46200368	86	29120											
ASPN	54829	broad.mit.edu	37	chr9	95219641	95219641	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaatgttgcaggttgcatttCccagtatttcaccgggttgt	8	15	10	8	1	1	0	1	0	0	0	2	0	2	0	2	2	2	6	2	2	2	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr9:95219641C>G	uc004ase.1	-	8	1316	c.1072G>C	c.(1072-1074)GAA>CAA	p.E358Q	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ASPN_uc010mqy.1_3'UTR	NM_017680	NP_060150	Q9BXN1	ASPN_HUMAN	asporin precursor	358	LRR 11.				bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding				0						GGTTGCATTTCCCAGTATTTC	0.373													6	46					0	0	0	0	G	95219641	G	G	95219641	3	3	160	1	0	0	0	0	1	0	0	0	1059	864	30	2	74	2	ASPN	9	95219641	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	206578	95219641	45993790	87	29121											
PTCH1	5727	broad.mit.edu	37	chr9	98268846	98268846	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtctctgaaacttcgctctCagccacagcggcgctttccg	7	10	9	15	4	2	1	1	1	2	0	6	1	3	1	2	1	3	2	2	1	1	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr9:98268846C>G	uc004avk.3	-	2	425	c.237G>C	c.(235-237)CTG>CTC	p.L79L	PTCH1_uc010mro.2_5'UTR|PTCH1_uc010mrp.2_5'UTR|PTCH1_uc010mrq.2_5'UTR|PTCH1_uc004avl.3_5'UTR|PTCH1_uc010mrr.2_Silent_p.L13L|PTCH1_uc004avm.3_Silent_p.L78L|PTCH1_uc010mrt.1_RNA|PTCH1_uc010mru.1_RNA|PTCH1_uc004avo.2_Silent_p.L13L|PTCH1_uc010mrv.1_Intron|PTCH1_uc010mrw.1_Intron	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	79	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				ACTTCGCTCTCAGCCACAGCG	0.592									Basal_Cell_Nevus_syndrome				4	40					0	0	0	0	G	98268846	G	G	98268846	2	3	160	1	0	0	0	0	0	0	0	1	12792	813	29	2		2	PTCH1	9	98268846	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	3049205	98268846	42944585	88	29122											
OR1J2	26740	broad.mit.edu	37	chr9	125273592	125273592	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccggctgtctttctgtgctgCgaacaccatcccccatgtct	5	12	8	16	2	3	0	0	0	3	0	4	1	4	0	4	1	3	2	4	1	1	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr9:125273592C>T	uc004bmj.1	+	4	1367	c.512C>T	c.(511-513)GCG>GTG	p.A171V	OR1J2_uc011lyv.1_Missense_Mutation_p.A171V	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|pancreas(1)|breast(1)	5						TTCTGTGCTGCGAACACCATC	0.532													18	136					0	0	0	0	T	125273592	T	T	125273592	3	4	160	1	0	0	0	0	1	0	0	0	11014	768	27	1	514	1	OR1J2	9	125273592	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	27004746	125273592	15939839	89	29123											
RXRA	6256	broad.mit.edu	37	chr9	137328333	137328333	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcgctaagctcttgctccGcctgccggctctgcgctcca	3	11	10	17	4	2	0	0	0	2	0	5	0	4	0	4	1	4	6	4	1	1	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr9:137328333G>A	uc004cfb.2	+	10	1424	c.1262G>A	c.(1261-1263)CGC>CAC	p.R421H	RXRA_uc004cfc.1_Missense_Mutation_p.R324H	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	421	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CTCTTGCTCCGCCTGCCGGCT	0.607													9	110					0	0	0	0	A	137328333	A	A	137328333	3	1	160	1	0	0	0	0	1	0	0	0	13828	1087	38	1	1300	1	RXRA	9	137328333	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	12054741	137328333	3885098	90	29124											
NOTCH1	4851	broad.mit.edu	37	chr9	139395018	139395018	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctacctggaagacaccttGtgcgtcggcagacacagccg	9	6	12	14	3	0	2	0	0	0	2	1	3	0	3	4	2	3	1	4	2	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr9:139395018G>A	uc004chz.2	-	31	5920	c.5920C>T	c.(5920-5922)CAA>TAA	p.Q1974*		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1974	ANK 2.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AAGACACCTTGTGCGTCGGCA	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			21	105					0	0	0	0	A	139395018	A	A	139395018	4	1	160	1	0	0	0	0	0	1	0	0	10601	1386	48	4	1763	4	NOTCH1	9	139395018	Nonsense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	2066685	139395018	1818413	91	29125											
CACNA1B	774	broad.mit.edu	37	chr9	140946543	140946543	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgtggcttctcccttctaGaggatccaaagggaaagaca	11	10	10	10	0	3	2	0	0	3	2	5	4	4	4	2	3	0	1	2	3	3	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr9:140946543G>A	uc004cog.2	+	25	3856	c.3711_splice	c.e25-1	p.S1237_splice	CACNA1B_uc011mfd.1_Splice_Site_p.S767_splice|CACNA1B_uc004coi.2_Splice_Site_p.G451_splice	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,						membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTCCCTTCTAGAGGATCCAAA	0.572													7	11					0	0	0	0	A	140946543	A	A	140946543	5	1	160	1	0	0	0	0	0	0	1	0	2551	956	33	2	3808	2	CACNA1B	9	140946543	Splice_Site	SNP	G	TCGA-CR-7394-01A-11D-2012-08	1551525	140946543	266888	92	29126											
GTPBP4	23560	broad.mit.edu	37	chr10	1061734	1061734	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaagatcccggagcatcacTaggaaaagaaagcgggaaga	18	3	13	7	2	1	4	1	0	0	4	2	7	2	7	1	3	2	1	1	3	6	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:1061734T>C	uc001ift.2	+	16	1721	c.1650T>C	c.(1648-1650)ACT>ACC	p.T550T	GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Silent_p.T434T|GTPBP4_uc010qae.1_Silent_p.T503T	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	550					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		GGAGCATCACTAGGAAAAGAA	0.507													10	93					0	0	0	0	C	1061734	C	C	1061734	2	2	160	1	0	0	0	0	0	0	0	1	6921	1509	53	5		5	GTPBP4	10	1061734	Silent	SNP	T	TCGA-CR-7394-01A-11D-2012-08		1061734	134473013	93	29127											
USP6NL	9712	broad.mit.edu	37	chr10	11567452	11567452	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcttcccaaggttcaatctCtgcaccttctcgtccctaaa	9	13	4	15	1	4	0	1	0	3	0	8	0	6	0	3	1	1	2	3	1	4	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:11567452C>T	uc001ikt.3	-	4	409	c.88G>A	c.(88-90)GAG>AAG	p.E30K	USP6NL_uc001iks.1_Missense_Mutation_p.E47K	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	30						intracellular	Rab GTPase activator activity				0						GGTTCAATCTCTGCACCTTCT	0.328													9	67					0	0	0	0	T	11567452	T	T	11567452	3	4	160	1	0	0	0	0	1	0	0	0	17155	922	32	2	2446	2	USP6NL	10	11567452	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	10505718	11567452	123967295	94	29128											
CUBN	8029	broad.mit.edu	37	chr10	16994286	16994286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttacttacatggaggttgcGcttgaatgatccagctgcag	9	12	12	8	1	0	2	0	2	0	0	1	3	1	3	1	2	5	5	1	2	3	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:16994286G>A	uc001ioo.2	-	33	5010	c.4958C>T	c.(4957-4959)GCG>GTG	p.A1653V		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1653	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGGAGGTTGCGCTTGAATGAT	0.458													10	91					0	0	0	0	A	16994286	A	A	16994286	3	1	160	1	0	0	0	0	1	0	0	0	4068	1087	38	1	6053	1	CUBN	10	16994286	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	5426834	16994286	118540461	95	29129											
BMI1	648	broad.mit.edu	37	chr10	22618452	22618452	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcatcagtaaatgggtcatCagcaacttcttctggttgat	11	14	8	8	0	6	1	4	1	2	0	6	1	6	1	0	2	2	3	0	2	3	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:22618452C>T	uc001irh.2	+	10	1601	c.962C>T	c.(961-963)TCA>TTA	p.S321L	BMI1_uc009xkg.2_Missense_Mutation_p.S464L	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene	321	Pro/Ser-rich.				hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						AATGGGTCATCAGCAACTTCT	0.393													8	79					0	0	0	0	T	22618452	T	T	22618452	3	4	160	1	0	0	0	0	1	0	0	0	1458	838	29	2	996	2	BMI1	10	22618452	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	5624166	22618452	112916295	96	29130											
KIF5B	3799	broad.mit.edu	37	chr10	32329358	32329359	+	Nonsense_Mutation	DNP	AT	TA	TA																															atgtttgtccatatgcaaatAttgttccattatatccttca																										TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:32329358_32329359AT>TA	uc001iwe.3	-	3	711_712	c.241_242AT>TA	c.(241-243)ATA>TAA	p.I81*		NM_004521	NP_004512	P33176	KINH_HUMAN	kinesin family member 5B	81	Kinesin-motor.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)				ATATGCAAATATTGTTCCATTA	0.332													5	34					0	0	0	0	TA	32329359	TA	TA	32329358	4	4	160	1	0	0	0	0	0	1	0	0	8345	449	16	5	2741	5	KIF5B	10	32329358	Nonsense_Mutation	DNP	AT	TCGA-CR-7394-01A-11D-2012-08	9710906	32329358	103205389	97	29131	58	2									
KIF5B	3799	broad.mit.edu	37	chr10	32329361	32329361	+	Missense_Mutation	SNP	G	A	A																															tttgtccatatgcaaatattGttccattatatccttcaagt																										TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:32329361G>A	uc001iwe.3	-	3	709	c.239C>T	c.(238-240)ACA>ATA	p.T80I		NM_004521	NP_004512	P33176	KINH_HUMAN	kinesin family member 5B	80	Kinesin-motor.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)				TGCAAATATTGTTCCATTATA	0.333													4	34					0	0	0	0	A	32329361	A	A	32329361	3	1	160	1	0	0	0	0	1	0	0	0	8345	1377	48	4	2744	4	KIF5B	10	32329361	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	3	32329361	103205386	98	29132	58	2									
RBP3	5949	broad.mit.edu	37	chr10	48387946	48387946	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatctcggctagggccacttCtgaggtcaccctggagtagc	7	9	13	12	1	3	1	1	1	2	0	4	3	3	2	2	4	1	2	2	4	2	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:48387946C>G	uc001jez.2	-	1	3046	c.2932G>C	c.(2932-2934)GAA>CAA	p.E978Q		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	978	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	AGGGCCACTTCTGAGGTCACC	0.617													6	91					0	0	0	0	G	48387946	G	G	48387946	3	3	160	1	0	0	0	0	1	0	0	0	13222	922	32	2	827	2	RBP3	10	48387946	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	16058585	48387946	87146801	99	29133											
RBP3	5949	broad.mit.edu	37	chr10	48388901	48388901	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccgcaggagggcactggtCtgccccacgacctctggccg	5	5	14	17	3	2	0	0	0	2	0	2	2	2	1	5	4	1	2	5	4	0	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:48388901C>G	uc001jez.2	-	1	2091	c.1977G>C	c.(1975-1977)CAG>CAC	p.Q659H		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	659	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GGGCACTGGTCTGCCCCACGA	0.672													4	37					0	0	0	0	G	48388901	G	G	48388901	3	3	160	1	0	0	0	0	1	0	0	0	13222	912	32	2	1782	2	RBP3	10	48388901	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	955	48388901	87145846	100	29134											
GDF2	2658	broad.mit.edu	37	chr10	48414224	48414224	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttggtggagtcggaccggAcccagcgcttcacggcgctg	5	8	15	13	5	2	0	1	0	1	0	3	3	2	3	2	5	1	2	2	5	0	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:48414224A>G	uc001jfa.1	-	2	807	c.644T>C	c.(643-645)GTC>GCC	p.V215A		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	215					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						GTCGGACCGGACCCAGCGCTT	0.587													9	103					0	0	0	0	G	48414224	G	G	48414224	3	3	160	1	0	0	0	0	1	0	0	0	6351	275	10	5	649	5	GDF2	10	48414224	Missense_Mutation	SNP	A	TCGA-CR-7394-01A-11D-2012-08	25323	48414224	87120523	101	29135											
OGDHL	55753	broad.mit.edu	37	chr10	50952758	50952758	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttatccttggacctgccaTaagcctcctcacagatccgg	8	12	7	14	1	1	1	1	0	0	1	4	2	4	2	6	2	2	0	6	2	2	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:50952758T>C	uc001jie.2	-	13	1812	c.1670A>G	c.(1669-1671)TAT>TGT	p.Y557C	OGDHL_uc009xog.2_Missense_Mutation_p.Y584C|OGDHL_uc010qgt.1_Missense_Mutation_p.Y500C|OGDHL_uc010qgu.1_Missense_Mutation_p.Y348C|OGDHL_uc009xoh.2_Missense_Mutation_p.Y348C	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	557					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGACCTGCCATAAGCCTCCTC	0.547													6	56					0	0	0	0	C	50952758	C	C	50952758	3	2	160	1	0	0	0	0	1	0	0	0	10894	1406	49	5	1406	5	OGDHL	10	50952758	Missense_Mutation	SNP	T	TCGA-CR-7394-01A-11D-2012-08	2538534	50952758	84581989	102	29136											
BLOC1S2	282991	broad.mit.edu	37	chr10	102039977	102039977	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatccagataaggctgcaGtccagcatctttaaaaacaa	15	9	7	10	0	1	2	0	1	1	1	3	2	3	2	2	1	3	3	2	1	5	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:102039977G>A	uc001kqw.1	-	4	324	c.301C>T	c.(301-303)CTG>TTG	p.L101L	BLOC1S2_uc001kqv.1_Silent_p.L58L	NM_173809	NP_776170	Q6QNY1	BL1S2_HUMAN	biogenesis of lysosome-related organelles	101	Potential.				melanosome organization|microtubule nucleation|platelet dense granule organization|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of apoptosis	BLOC-1 complex|centrosome|gamma-tubulin complex|nucleus	gamma-tubulin binding|identical protein binding|protein C-terminus binding			ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.44e-10)|all cancers(201;1.97e-08)		TAAGGCTGCAGTCCAGCATCT	0.363													3	59					0	0	0	0	A	102039977	A	A	102039977	2	1	160	1	0	0	0	0	0	0	0	1	1452	1020	36	4		4	BLOC1S2	10	102039977	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	51087219	102039977	33494770	103	29137											
NFKB2	4791	broad.mit.edu	37	chr10	104157126	104157126	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggactatgatacaaaaacttCagaggcagcggctccgctct	12	8	10	11	2	2	2	1	1	1	1	3	3	3	3	1	3	3	3	1	3	4	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:104157126C>T	uc001kvb.2	+	7	728	c.463C>T	c.(463-465)CAG>TAG	p.Q155*	NFKB2_uc001kva.2_Nonsense_Mutation_p.Q155*|NFKB2_uc010qqk.1_Nonsense_Mutation_p.Q155*|NFKB2_uc001kvd.2_Nonsense_Mutation_p.Q155*|NFKB2_uc009xxc.2_Nonsense_Mutation_p.Q155*	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	155	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		ACAAAAACTTCAGAGGCAGCG	0.572			T	IGH@	B-NHL								4	121					0	0	0	0	T	104157126	T	T	104157126	4	4	160	1	0	0	0	0	0	1	0	0	10430	827	29	2	485	2	NFKB2	10	104157126	Nonsense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	2117149	104157126	31377621	104	29138											
PSD	5662	broad.mit.edu	37	chr10	104163637	104163637	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccttctgccgctgctcttCagcctccttgccccggccct	1	12	7	21	2	3	0	1	0	2	0	5	0	5	0	7	1	4	2	7	1	0	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:104163637C>T	uc001kvg.1	-	16	3333	c.2806G>A	c.(2806-2808)GAA>AAA	p.E936K	PSD_uc001kve.1_Missense_Mutation_p.E143K|PSD_uc001kvf.1_Missense_Mutation_p.E305K|PSD_uc001kvh.1_Missense_Mutation_p.E557K|PSD_uc009xxd.1_Missense_Mutation_p.E936K	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	936					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CGCTGCTCTTCAGCCTCCTTG	0.662													4	17					0	0	0	0	T	104163637	T	T	104163637	3	4	160	1	0	0	0	0	1	0	0	0	12708	835	29	2	276	2	PSD	10	104163637	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	6511	104163637	31371110	105	29139											
CUZD1	50624	broad.mit.edu	37	chr10	124596554	124596554	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaaatttgcactgtttgtCtatttctaggctagagaatg	11	16	8	6	0	3	1	1	0	2	1	3	2	3	1	0	1	1	3	0	1	5	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:124596554C>T	uc001lgq.2	-	5	942	c.610G>A	c.(610-612)GAC>AAC	p.D204N	CUZD1_uc001lgp.2_5'UTR|CUZD1_uc009yad.2_5'UTR|CUZD1_uc009yaf.2_Intron|CUZD1_uc001lgr.2_5'UTR|CUZD1_uc010qty.1_Intron|CUZD1_uc009yae.2_Intron|CUZD1_uc001lgs.2_Missense_Mutation_p.D204N|CUZD1_uc010qtz.1_Missense_Mutation_p.D204N	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor	204	Extracellular (Potential).|CUB 2.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		CACTGTTTGTCTATTTCTAGG	0.428													10	20					0	0	0	0	T	124596554	T	T	124596554	3	4	160	1	0	0	0	0	1	0	0	0	4083	913	32	2	1233	2	CUZD1	10	124596554	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	20432917	124596554	10938193	106	29140											
GPR26	2849	broad.mit.edu	37	chr10	125426416	125426416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgcagccggcggccagacGagcgcctgcgcttcgccgtc	4	6	15	16	7	0	1	0	0	0	1	2	2	0	1	4	2	4	2	4	2	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:125426416G>A	uc001lhh.2	+	1	546	c.493G>A	c.(493-495)GAG>AAG	p.E165K		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	165	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				GCGGCCAGACGAGCGCCTGCG	0.677													6	23					0	0	0	0	A	125426416	A	A	125426416	3	1	160	1	0	0	0	0	1	0	0	0	6722	1059	37	1	495	1	GPR26	10	125426416	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	829862	125426416	10108331	107	29141											
PTPRE	5791	broad.mit.edu	37	chr10	129839247	129839247	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacagcaacgagacaaccacGacctcaggtaaggacccctt	14	4	9	14	2	1	1	1	0	0	1	1	5	1	2	4	2	3	2	4	2	3	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:129839247G>A	uc001lkb.2	+	3	381	c.102G>A	c.(100-102)ACG>ACA	p.T34T	PTPRE_uc009yat.2_Silent_p.T45T|PTPRE_uc010qup.1_RNA|PTPRE_uc009yau.2_Silent_p.T34T|PTPRE_uc001lkc.1_RNA	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	34	Extracellular (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				AGACAACCACGACCTCAGGTA	0.592													3	28					0	0	0	0	A	129839247	A	A	129839247	2	1	160	1	0	0	0	0	0	0	0	1	12865	1045	37	1		1	PTPRE	10	129839247	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	4412831	129839247	5695500	108	29142											
MKI67	4288	broad.mit.edu	37	chr10	129914118	129914118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattacgtccagcatgttctGaggaatgaacattagttgtt	11	14	9	7	1	1	2	0	2	1	0	2	3	2	3	1	1	3	4	1	1	4	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr10:129914118G>A	uc001lke.2	-	7	749	c.554C>T	c.(553-555)TCA>TTA	p.S185L	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	185					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				AGCATGTTCTGAGGAATGAAC	0.413													17	104					0	0	0	0	A	129914118	A	A	129914118	3	1	160	1	0	0	0	0	1	0	0	0	9651	1294	45	2	9252	2	MKI67	10	129914118	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	74871	129914118	5620629	109	29143											
HRAS	3265	broad.mit.edu	37	chr11	534289	534289	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcactcttgcccacaccgcCggcgcccaccaccaccagct	7	4	7	23	4	1	0	0	0	1	0	1	0	1	0	7	1	2	2	7	1	0	1	rs104894229		TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:534289C>T	uc001lpv.2	-	2	222	c.34G>A	c.(34-36)GGC>AGC	p.G12S	HRAS_uc010qvw.1_Missense_Mutation_p.G12S|HRAS_uc010qvx.1_Missense_Mutation_p.G12S|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	12	GTP.		G -> S (in FCSS, OSCC and CMEMS).|G -> E (in FCSS).|G -> C (in FCSS).|G -> A (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12V(250)|p.G12S(54)|p.G12D(39)|p.G12C(23)|p.G12R(12)|p.G12A(7)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CCCACACCGCCGGCGCCCACC	0.647		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			5	41					0	0	0	0	T	534289	T	T	534289	3	4	160	1	0	0	0	0	1	0	0	0	7387	652	23	1	618	1	HRAS	11	534289	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08		534289	134472227	110	29144											
TNNI2	7136	broad.mit.edu	37	chr11	1862066	1862066	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taggagctctgcaaacagctGcacgccaagatcgatgcggc	11	6	12	12	3	1	1	0	0	1	1	2	3	1	2	1	2	6	4	1	2	3	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:1862066G>A	uc010qxe.1	+	4	226	c.204G>A	c.(202-204)CTG>CTA	p.L68L	TNNI2_uc010qxc.1_Silent_p.L66L|TNNI2_uc010qxd.1_Silent_p.L66L	NM_001145841	NP_001139313	P48788	TNNI2_HUMAN	fast-twitch skeletal muscle troponin I isoform	68					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding				0		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCAAACAGCTGCACGCCAAGA	0.597													4	28					0	0	0	0	A	1862066	A	A	1862066	2	1	160	1	0	0	0	0	0	0	0	1	16393	1306	46	4		4	TNNI2	11	1862066	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	1327777	1862066	133144450	111	29145											
OR51A4	401666	broad.mit.edu	37	chr11	4967899	4967899	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gagaatactatccctatttgGgcaactctgacagttgtcag	11	12	9	9	0	2	2	1	1	1	1	3	3	3	2	1	1	2	2	1	1	5	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:4967899G>A	uc010qys.1	-	1	432	c.432C>T	c.(430-432)GCC>GCT	p.A144A		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCCCTATTTGGGCAACTCTGA	0.428													32	179					0	0	0	0	A	4967899	A	A	4967899	2	1	160	1	0	0	0	0	0	0	0	1	11141	1219	43	4		4	OR51A4	11	4967899	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	3105833	4967899	130038617	112	29146											
OR51B2	79345	broad.mit.edu	37	chr11	5344774	5344774	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaatgtcaaacccatcactgTaacatagaagataagaacac	19	7	6	9	0	2	3	2	0	0	3	2	4	2	3	1	0	3	1	1	0	7	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:5344774T>C	uc001mao.1	-	1	809	c.754A>G	c.(754-756)ACA>GCA	p.T252A	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCATCACTGTAACATAGAAG	0.388													3	42					0	0	0	0	C	5344774	C	C	5344774	3	2	160	1	0	0	0	0	1	0	0	0	11143	1638	57	5	188	5	OR51B2	11	5344774	Missense_Mutation	SNP	T	TCGA-CR-7394-01A-11D-2012-08	376875	5344774	129661742	113	29147											
C11orf41	25758	broad.mit.edu	37	chr11	33581457	33581457	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgccgctaaccattgctgaaCgtgagtatggccatgcctat	9	10	10	12	3	0	2	0	2	0	0	0	2	0	2	4	1	4	3	4	1	4	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:33581457C>T	uc001mup.3	+	6	3269	c.3145C>T	c.(3145-3147)CCA>TCA	p.P1049S	C11orf41_uc001mun.1_Missense_Mutation_p.P1049S	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1043						integral to membrane				ovary(2)	2						CATTGCTGAACGTGAGTATGG	0.547													9	197					0	0	0	0	T	33581457	T	T	33581457	3	4	160	1	0	0	0	0	1	0	0	0	1646	550	19	1	3167	1	C11orf41	11	33581457	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	28236683	33581457	101425059	114	29148											
GYLTL1B	120071	broad.mit.edu	37	chr11	45950273	45950273	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcttccgctccagccccacCtatcgtgactgcctccaggc	5	8	8	20	3	0	1	0	1	0	0	4	1	3	1	7	1	2	2	7	1	1	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:45950273C>G	uc001nbv.1	+	14	2154	c.2043C>G	c.(2041-2043)ACC>ACG	p.T681T	GYLTL1B_uc001nbw.1_Silent_p.T650T|GYLTL1B_uc001nbx.1_Silent_p.T681T|GYLTL1B_uc001nby.1_Silent_p.T364T|GYLTL1B_uc001nbz.1_Missense_Mutation_p.P30R	NM_152312	NP_689525	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	681	Lumenal (Potential).				muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.226)		CCAGCCCCACCTATCGTGACT	0.637													8	115					0	0	0	0	G	45950273	G	G	45950273	2	3	160	1	0	0	0	0	0	0	0	1	6946	668	24	4		4	GYLTL1B	11	45950273	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	12368816	45950273	89056243	115	29149											
MADD	8567	broad.mit.edu	37	chr11	47317523	47317523	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggtgatggaccaggtggcGagggcagtgttcacctggca	8	7	17	9	1	1	1	1	1	0	0	1	3	1	2	2	6	0	3	2	6	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:47317523G>A	uc001ner.1	+	24	3867	c.3676G>A	c.(3676-3678)GAG>AAG	p.E1226K	MADD_uc001neq.2_Missense_Mutation_p.E1188K|MADD_uc001nev.1_Missense_Mutation_p.E1145K|MADD_uc001nes.1_Missense_Mutation_p.E1165K|MADD_uc001net.1_Missense_Mutation_p.E1208K|MADD_uc009yln.1_Missense_Mutation_p.E1141K|MADD_uc001neu.1_Missense_Mutation_p.E1145K|MADD_uc001nex.2_Missense_Mutation_p.E1226K|MADD_uc001nez.2_Missense_Mutation_p.E1144K|MADD_uc001new.2_Missense_Mutation_p.E1187K|MADD_uc009ylo.2_Missense_Mutation_p.E140K	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1226	Ser-rich.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		ACCAGGTGGCGAGGGCAGTGT	0.483													16	114					0	0	0	0	A	47317523	A	A	47317523	3	1	160	1	0	0	0	0	1	0	0	0	9203	1059	37	1	3766	1	MADD	11	47317523	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	1367250	47317523	87688993	116	29150											
B3GAT3	26229	broad.mit.edu	37	chr11	62389338	62389338	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccgccccgccccgctcacCgagctgtaccagcgcgtaga	6	4	10	21	6	1	1	1	0	0	1	1	2	1	1	8	0	3	4	8	0	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:62389338C>T	uc001ntw.2	-	1	111	c.82G>A	c.(82-84)GGC>AGC	p.G28S	B3GAT3_uc009ynz.2_Translation_Start_Site|B3GAT3_uc001ntx.2_Intron|B3GAT3_uc010rlz.1_Missense_Mutation_p.G28S	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	28	Helical; Signal-anchor for type II membrane protein; (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						ccccgcTCACCGAGCTGTACC	0.388													3	37					0	0	0	0	T	62389338	T	T	62389338	3	4	160	1	0	0	0	0	1	0	0	0	1257	666	23	1	945	1	B3GAT3	11	62389338	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	15071815	62389338	72617178	117	29151											
BSCL2	26580	broad.mit.edu	37	chr11	62457987	62457987	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagctgcatcttcccaggagCctgaacctgggccaggaaag	11	6	12	12	0	1	1	0	1	1	0	2	3	2	3	4	3	4	2	4	3	3	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:62457987C>A	uc001nuo.1	-	11	1473	c.1049G>T	c.(1048-1050)GGC>GTC	p.G350V	LRRN4CL_uc001nun.2_5'Flank|BSCL2_uc009yoc.1_3'UTR|BSCL2_uc001nup.2_Missense_Mutation_p.G350V|BSCL2_uc001nuq.1_Missense_Mutation_p.G350V|BSCL2_uc001nur.3_Missense_Mutation_p.G414V|BSCL2_uc009yod.2_Missense_Mutation_p.G414V|BSCL2_uc001nut.3_Missense_Mutation_p.G416V|HNRNPUL2_uc001nuu.1_RNA	NM_032667	NP_116056	Q96G97	BSCL2_HUMAN	seipin isoform 2	350	Cytoplasmic (Potential).				cell death	integral to endoplasmic reticulum membrane					0						TTCCCAGGAGCCTGAACCTGG	0.572													3	41					0.004672	0.00492194	1	0	A	62457987	A	A	62457987	3	1	160	1	0	0	0	0	1	0	0	0	1532	739	26	4	151	4	BSCL2	11	62457987	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	68649	62457987	72548529	118	29152											
PPP1R14B	26472	broad.mit.edu	37	chr11	64012227	64012227	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcctgggtcggggaccgtCacttcttctggggtgtgctc	2	13	14	12	2	4	0	1	0	3	0	7	1	4	1	2	5	1	1	2	5	0	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:64012227C>T	uc001nza.2	-	4	711	c.443G>A	c.(442-444)TGA>TAA	p.*148*		NM_138689	NP_619634	Q96C90	PP14B_HUMAN	protein phosphatase 1 regulatory subunit 14B	148					regulation of phosphorylation	cytoplasm	protein phosphatase inhibitor activity				0						CGGGGACCGTCACTTCTTCTG	0.617													5	47					0	0	0	0	T	64012227	T	T	64012227	2	4	160	1	0	0	0	0	0	0	0	1	12420	837	29	2		2	PPP1R14B	11	64012227	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	1554240	64012227	70994289	119	29153											
CCDC87	55231	broad.mit.edu	37	chr11	66358522	66358522	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgtgctctagcacagtgttCcaatcccactctcctggcac	7	11	7	16	0	2	0	0	0	2	0	5	0	4	0	3	1	2	4	3	1	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:66358522C>T	uc001oiq.3	-	1	2033	c.1965G>A	c.(1963-1965)TGG>TGA	p.W655*	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	655										ovary(1)|skin(1)	2						GCACAGTGTTCCAATCCCACT	0.542													10	94					0	0	0	0	T	66358522	T	T	66358522	4	4	160	1	0	0	0	0	0	1	0	0	2875	856	30	2	588	2	CCDC87	11	66358522	Nonsense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	2346295	66358522	68647994	120	29154											
RBM4	5936	broad.mit.edu	37	chr11	66407347	66407347	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggatgccatacgcaacctGcaccattacaagcttcatgg	12	8	9	12	1	1	0	1	0	0	0	1	2	1	1	3	2	6	3	3	2	4	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:66407347G>A	uc009yrj.2	+	2	653	c.165G>A	c.(163-165)CTG>CTA	p.L55L	RBM4_uc009yrk.2_Intron|RBM4_uc001oiv.2_Silent_p.L55L|RBM4_uc001oiw.1_Silent_p.L55L|RBM4_uc001oix.1_Silent_p.L55L|RBM4_uc010rpj.1_Silent_p.L55L|RBM4_uc001oiy.1_Silent_p.L55L|RBM4_uc001oiz.1_Silent_p.L55L	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	55	RRM 1.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		TACGCAACCTGCACCATTACA	0.478													20	168					0	0	0	0	A	66407347	A	A	66407347	2	1	160	1	0	0	0	0	0	0	0	1	13199	1306	46	4		4	RBM4	11	66407347	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	48825	66407347	68599169	121	29155											
ADRBK1	156	broad.mit.edu	37	chr11	67050604	67050604	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactcctctctaaaggccgtGgagctgcccgactccttctc	6	10	8	17	2	2	0	0	0	2	0	6	2	4	1	4	2	2	1	4	2	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:67050604G>A	uc009yrn.1	+	15	1499	c.1233G>A	c.(1231-1233)GTG>GTA	p.V411V	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	411	Protein kinase.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	TAAAGGCCGTGGAGCTGCCCG	0.647													14	127					0	0	0	0	A	67050604	A	A	67050604	2	1	160	1	0	0	0	0	0	0	0	1	343	1335	47	4		4	ADRBK1	11	67050604	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	643257	67050604	67955912	122	29156											
DNAJB13	374407	broad.mit.edu	37	chr11	73681032	73681032	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atacttcaagaaggtgccagGggaggggatgccattgccgg	10	7	16	8	1	1	1	1	0	0	1	1	3	1	3	3	6	4	0	3	6	3	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:73681032G>A	uc001ouo.2	+	8	1575	c.824G>A	c.(823-825)GGG>GAG	p.G275E		NM_153614	NP_705842	P59910	DJB13_HUMAN	testis spermatogenesis apoptosis-related protein	275					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding				0	Breast(11;7.42e-05)					AAGGTGCCAGGGGAGGGGATG	0.542													10	162					0	0	0	0	A	73681032	A	A	73681032	3	1	160	1	0	0	0	0	1	0	0	0	4640	1232	43	4	854	4	DNAJB13	11	73681032	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	6630428	73681032	61325484	123	29157											
NCAM1	4684	broad.mit.edu	37	chr11	113102481	113102481	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaccgccagcaacaccatcGgccaggactcccagtccatg	10	4	9	18	2	0	0	0	0	0	0	3	1	2	1	6	2	2	2	6	2	1	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:113102481G>A	uc009yyq.1	+	11	1622	c.928G>A	c.(928-930)GGC>AGC	p.G310S		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	402	Ig-like C2-type 4.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		CAACACCATCGGCCAGGACTC	0.582													9	99					0	0	0	0	A	113102481	A	A	113102481	3	1	160	1	0	0	0	0	1	0	0	0	10256	1116	39	1	1243	1	NCAM1	11	113102481	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	39421449	113102481	21904035	124	29158											
POU2F3	25833	broad.mit.edu	37	chr11	120170369	120170369	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atccgctccagcagcttgtgCtggttcccggccacttacag	6	10	10	15	2	0	0	0	0	0	0	3	0	3	0	4	2	4	5	4	2	1	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr11:120170369C>A	uc001pxc.2	+	5	397	c.295C>A	c.(295-297)CTG>ATG	p.L99M	POU2F3_uc010rzk.1_Missense_Mutation_p.A37D|POU2F3_uc010rzl.1_Missense_Mutation_p.L29M	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	99					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		GCAGCTTGTGCTGGTTCCCGG	0.552											OREG0021419	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	66					0.00448238	0.00474169	1	0	A	120170369	A	A	120170369	3	1	160	1	0	0	0	0	1	0	0	0	12328	796	28	4	313	4	POU2F3	11	120170369	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	7067888	120170369	14836147	125	29159											
ARID2	196528	broad.mit.edu	37	chr12	46245723	46245723	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagaacccgtcctgccgaCgaggagccacaaacaccagc	12	3	11	15	3	0	1	0	0	0	1	1	5	1	2	5	2	5	0	5	2	2	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr12:46245723C>T	uc001ros.1	+	15	3817	c.3817C>T	c.(3817-3819)CGA>TGA	p.R1273*	ARID2_uc001ror.2_Nonsense_Mutation_p.R1273*|ARID2_uc009zkg.1_Nonsense_Mutation_p.R729*|ARID2_uc009zkh.1_Nonsense_Mutation_p.R900*|ARID2_uc001rou.1_Nonsense_Mutation_p.R607*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1273					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GTCCTGCCGACGAGGAGCCAC	0.428													5	55					0	0	0	0	T	46245723	T	T	46245723	4	4	160	1	0	0	0	0	0	1	0	0	915	528	19	1	3875	1	ARID2	12	46245723	Nonsense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08		46245723	87606172	126	29160											
TUBA1A	7846	broad.mit.edu	37	chr12	49580117	49580117	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgcgaattcggtccaacacGaggtcaatgatctccttgcc	9	11	9	12	3	2	1	1	1	1	0	5	3	3	1	3	2	3	0	3	2	3	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr12:49580117G>A	uc009zlf.2	-	3	623	c.351C>T	c.(349-351)CTC>CTT	p.L117L	TUBA1B_uc001rto.2_Silent_p.L82L|TUBA1A_uc001rtp.2_Silent_p.L117L|TUBA1A_uc001rtq.2_Intron|TUBA1A_uc001rtr.2_5'UTR|TUBA1A_uc009zlg.2_5'UTR	NM_006009	NP_006000	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	117					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity				0						GGTCCAACACGAGGTCAATGA	0.413													16	146					0	0	0	0	A	49580117	A	A	49580117	2	1	160	1	0	0	0	0	0	0	0	1	16811	1045	37	1		1	TUBA1A	12	49580117	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	3334394	49580117	84271778	127	29161											
KRT5	3852	broad.mit.edu	37	chr12	52913991	52913991	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgggacacggaggtgaagctGgtgcgggagacagacggggt	9	4	21	7	4	0	3	0	1	0	2	0	6	0	5	0	7	2	1	0	7	1	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr12:52913991G>A	uc001san.2	-	1	253	c.90C>T	c.(88-90)ACC>ACT	p.T30T	KRT5_uc009zmh.2_Silent_p.T30T	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	30	Head.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGGTGAAGCTGGTGCGGGAGA	0.662													3	53					0	0	0	0	A	52913991	A	A	52913991	2	1	160	1	0	0	0	0	0	0	0	1	8518	1335	47	4		4	KRT5	12	52913991	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	3333874	52913991	80937904	128	29162											
OR6C75	390323	broad.mit.edu	37	chr12	55758919	55758919	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaattccacagcagtaacaGactttattcttcttggattg	12	14	7	8	0	2	1	0	0	2	1	3	3	3	2	1	1	2	2	1	1	3	8			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr12:55758919G>A	uc010spk.1	+	1	25	c.25G>A	c.(25-27)GAC>AAC	p.D9N		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						AGCAGTAACAGACTTTATTCT	0.353													4	123					0	0	0	0	A	55758919	A	A	55758919	3	1	160	1	0	0	0	0	1	0	0	0	11253	942	33	2	27	2	OR6C75	12	55758919	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	2844928	55758919	78092976	129	29163											
EP400	57634	broad.mit.edu	37	chr12	132502171	132502171	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaaccaccctgggctcgtcGagccccggcacccaggctct	6	5	11	19	3	1	0	0	0	1	0	3	1	1	0	5	3	2	4	5	3	1	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr12:132502171G>A	uc001ujn.2	+	19	4050	c.4015G>A	c.(4015-4017)GAG>AAG	p.E1339K	EP400_uc001ujl.2_Missense_Mutation_p.E1338K|EP400_uc001ujm.2_Missense_Mutation_p.E1339K	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1375					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TGGGCTCGTCGAGCCCCGGCA	0.612													7	65					0	0	0	0	A	132502171	A	A	132502171	3	1	160	1	0	0	0	0	1	0	0	0	5173	1059	37	1	4086	1	EP400	12	132502171	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	76743252	132502171	1349724	130	29164											
PXMP2	5827	broad.mit.edu	37	chr12	133277837	133277837	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgccttccctcctttgcaggGgaaagacgcctcagccttcg	6	9	10	16	3	1	1	1	0	0	1	4	2	3	2	5	2	2	1	5	2	1	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr12:133277837G>A	uc001ukt.2	+	4	466	c.401G>A	c.(400-402)GGG>GAG	p.G134E	PGAM5_uc010tbr.1_RNA	NM_018663	NP_061133	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa	134	Helical; (Potential).					integral to membrane|peroxisomal membrane	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		CCTTTGCAGGGGAAAGACGCC	0.572													15	165					0	0	0	0	A	133277837	A	A	133277837	3	1	160	1	0	0	0	0	1	0	0	0	12915	1246	43	4	415	4	PXMP2	12	133277837	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	775666	133277837	574058	131	29165											
GOLGA3	2802	broad.mit.edu	37	chr12	133362956	133362956	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctgctgtcactgctgccaCcctgggctcggagctggccc	3	8	14	16	1	1	0	1	0	0	0	2	1	1	1	3	4	4	5	3	4	0	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr12:133362956C>T	uc001ukz.1	-	15	3651	c.3092G>A	c.(3091-3093)GGT>GAT	p.G1031D	GOLGA3_uc001ula.1_Missense_Mutation_p.G1031D|GOLGA3_uc001ulb.2_Missense_Mutation_p.G1031D	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1031	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		ACTGCTGCCACCCTGGGCTCG	0.692													5	41					0	0	0	0	T	133362956	T	T	133362956	3	4	160	1	0	0	0	0	1	0	0	0	6591	507	18	4	1582	4	GOLGA3	12	133362956	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	85119	133362956	488939	132	29166											
NUPL1	9818	broad.mit.edu	37	chr13	25914137	25914137	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtacatctgggtttaacttCagcaatcctggcatcacggc	10	11	9	11	1	3	0	2	0	1	0	4	0	4	0	1	3	3	4	1	3	3	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr13:25914137C>T	uc001uqi.2	+	16	1911	c.1665C>T	c.(1663-1665)TTC>TTT	p.F555F	NUPL1_uc001uqj.2_Silent_p.F543F	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	555	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		GGTTTAACTTCAGCAATCCTG	0.418													4	129					0	0	0	0	T	25914137	T	T	25914137	2	4	160	1	0	0	0	0	0	0	0	1	10828	825	29	2		2	NUPL1	13	25914137	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08		25914137	89255741	133	29167											
SLC46A3	283537	broad.mit.edu	37	chr13	29278221	29278221	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgtttctaagaaagcaataCaagcaaacagggtacctgtt	15	10	9	7	0	1	1	0	0	1	1	1	1	1	1	1	1	5	5	1	1	7	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr13:29278221C>T	uc001usi.2	-	4	2130	c.1160G>A	c.(1159-1161)TGT>TAT	p.C387Y	SLC46A3_uc001usg.2_Missense_Mutation_p.C312Y|SLC46A3_uc001usj.2_Missense_Mutation_p.C387Y|SLC46A3_uc001ush.2_Missense_Mutation_p.C387Y	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	387	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)		GAAAGCAATACAAGCAAACAG	0.398													5	70					0	0	0	0	T	29278221	T	T	29278221	3	4	160	1	0	0	0	0	1	0	0	0	14710	478	17	4	247	4	SLC46A3	13	29278221	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	3364084	29278221	85891657	134	29168											
STARD13	90627	broad.mit.edu	37	chr13	33859613	33859613	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgccggccactcaccttgttGaattttagtcactagctgat	8	14	8	11	1	2	2	2	2	0	0	2	2	2	2	3	1	2	2	3	1	3	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr13:33859613G>C	uc001uuw.2	-	1	289	c.163C>G	c.(163-165)CAA>GAA	p.Q55E	STARD13_uc001uux.2_Intron|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Intron	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	55	SAM.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		TCACCTTGTTGAATTTTAGTC	0.458													8	113					0	0	0	0	C	33859613	C	C	33859613	3	2	160	1	0	0	0	0	1	0	0	0	15322	1299	45	2	3383	2	STARD13	13	33859613	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	4581392	33859613	81310265	135	29169											
COG6	57511	broad.mit.edu	37	chr13	40261891	40261891	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatcaagctactgcttctGaaaaggaacaccttgaagct	13	10	7	11	0	2	2	1	2	1	0	3	3	3	3	2	1	5	3	2	1	6	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr13:40261891G>A	uc001uxh.2	+	10	1064	c.964G>A	c.(964-966)GAA>AAA	p.E322K	COG6_uc001uxi.2_Missense_Mutation_p.E270K|COG6_uc010acb.2_Missense_Mutation_p.E322K	NM_020751	NP_065802	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6 isoform	322					protein transport	Golgi membrane|Golgi transport complex				kidney(1)|skin(1)	2		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		TACTGCTTCTGAAAAGGAACA	0.373													5	64					0	0	0	0	A	40261891	A	A	40261891	3	1	160	1	0	0	0	0	1	0	0	0	3677	1291	45	2	1002	2	COG6	13	40261891	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	6402278	40261891	74907987	136	29170											
C13orf31	144811	broad.mit.edu	37	chr13	44463085	44463085	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtacaactatttgattcacCaaatccctgtatcgacatcc	12	13	4	12	1	1	1	1	1	0	0	4	2	3	1	3	0	2	2	3	0	5	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr13:44463085C>T	uc010acg.2	+	5	1585	c.1100C>T	c.(1099-1101)CCA>CTA	p.P367L	C13orf31_uc001uzf.3_Missense_Mutation_p.P367L	NM_001128303	NP_001121775	Q8IV20	CM031_HUMAN	hypothetical protein LOC144811	367											0		Lung NSC(96;0.000163)|all_hematologic(4;0.0127)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Breast(139;0.0364)|Lung SC(185;0.0367)|Acute lymphoblastic leukemia(4;0.138)		GBM - Glioblastoma multiforme(144;0.000573)|BRCA - Breast invasive adenocarcinoma(63;0.121)		TTTGATTCACCAAATCCCTGT	0.373													4	78					0	0	0	0	T	44463085	T	T	44463085	3	4	160	1	0	0	0	0	1	0	0	0	1732	594	21	4	1114	4	C13orf31	13	44463085	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	4201194	44463085	70706793	137	29171											
SUPT16H	11198	broad.mit.edu	37	chr14	21822578	21822578	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acactcacgcacctcaccctCaggctccaggaaagaccagc	12	4	7	18	1	3	1	3	0	0	1	4	2	4	2	4	2	1	2	4	2	1	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr14:21822578C>T	uc001wao.2	-	23	3121	c.2782G>A	c.(2782-2784)GAG>AAG	p.E928K	SUPT16H_uc001wan.2_Missense_Mutation_p.E72K	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	928	Glu-rich (acidic).				DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		ACCTCACCCTCAGGCTCCAGG	0.478													6	46					0	0	0	0	T	21822578	T	T	21822578	3	4	160	1	0	0	0	0	1	0	0	0	15462	835	29	2	377	2	SUPT16H	14	21822578	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08		21822578	85526962	138	29172											
SUPT16H	11198	broad.mit.edu	37	chr14	21825367	21825367	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttacttacttcaaccattcCttgatggggtcaagagaggc	10	13	9	9	0	2	2	2	1	0	1	3	3	3	2	2	3	3	0	2	3	4	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr14:21825367C>T	uc001wao.2	-	22	2988	c.2649G>A	c.(2647-2649)AAG>AAA	p.K883K	SUPT16H_uc001wan.2_Silent_p.K27K	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	883					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TCAACCATTCCTTGATGGGGT	0.413													3	16					0	0	0	0	T	21825367	T	T	21825367	2	4	160	1	0	0	0	0	0	0	0	1	15462	680	24	4		4	SUPT16H	14	21825367	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	2789	21825367	85524173	139	29173											
SUPT16H	11198	broad.mit.edu	37	chr14	21826091	21826091	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtaagaaacactcacccattCcgtagcatttaccagcgcac	13	8	6	14	2	1	1	1	0	0	1	2	1	2	1	3	0	4	4	3	0	4	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr14:21826091C>T	uc001wao.2	-	21	2824	c.2485G>A	c.(2485-2487)GAA>AAA	p.E829K	SUPT16H_uc001wan.2_5'UTR	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	829					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CTCACCCATTCCGTAGCATTT	0.368													4	37					0	0	0	0	T	21826091	T	T	21826091	3	4	160	1	0	0	0	0	1	0	0	0	15462	864	30	2	682	2	SUPT16H	14	21826091	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	724	21826091	85523449	140	29174											
AKAP6	9472	broad.mit.edu	37	chr14	33292668	33292668	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaaataagaaaactattttCaaagttaataaagatccata	22	11	4	4	0	1	2	1	0	0	2	2	3	2	2	1	0	1	1	1	0	11	7	rs113957453		TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr14:33292668C>G	uc001wrq.2	+	13	5819	c.5649C>G	c.(5647-5649)TTC>TTG	p.F1883L		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1883					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AAACTATTTTCAAAGTTAATA	0.353													3	28					0	0	0	0	G	33292668	G	G	33292668	3	3	160	1	0	0	0	0	1	0	0	0	455	825	29	2	5695	2	AKAP6	14	33292668	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	11466577	33292668	74056872	141	29175											
SLC38A6	145389	broad.mit.edu	37	chr14	61510219	61510219	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctctttcatttctccaaaGaggtgtgtaagttattaaca	12	15	7	7	0	3	1	1	0	2	1	4	1	3	1	1	1	2	3	1	1	4	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr14:61510219G>C	uc001xfg.1	+	10	858	c.742G>C	c.(742-744)GAG>CAG	p.E248Q	SLC38A6_uc001xfh.1_Missense_Mutation_p.E248Q|SLC38A6_uc001xfi.2_RNA|SLC38A6_uc001xfj.1_RNA|SLC38A6_uc001xfk.2_RNA|SLC38A6_uc010trz.1_Missense_Mutation_p.E225Q	NM_153811	NP_722518	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	248					amino acid transport|sodium ion transport	integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TTTCTCCAAAGAGGTGTGTAA	0.343													4	46					0	0	0	0	C	61510219	C	C	61510219	3	2	160	1	0	0	0	0	1	0	0	0	14672	943	33	2	780	2	SLC38A6	14	61510219	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	28217551	61510219	45839321	142	29176											
CPSF2	53981	broad.mit.edu	37	chr14	92625471	92625471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaaggagaactaaaggatGatggagaagactcagagatg	19	5	14	3	0	1	6	1	1	0	5	1	10	1	7	0	3	1	0	0	3	6	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr14:92625471G>A	uc001yah.1	+	14	2203	c.1966G>A	c.(1966-1968)GAT>AAT	p.D656N		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	656					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		ACTAAAGGATGATGGAGAAGA	0.413													5	44					0	0	0	0	A	92625471	A	A	92625471	3	1	160	1	0	0	0	0	1	0	0	0	3840	1290	45	2	2012	2	CPSF2	14	92625471	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	31115252	92625471	14724069	143	29177											
SERPINA10	51156	broad.mit.edu	37	chr14	94750479	94750479	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcatcaacttcaatcacTgttctttgtaaaacctggaa	12	15	4	10	0	5	0	4	0	1	0	5	1	5	1	1	1	2	2	1	1	5	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr14:94750479T>G	uc001yct.2	-	5	1624	c.1158A>C	c.(1156-1158)ACA>ACC	p.T386T	SERPINA10_uc001ycu.3_Silent_p.T386T	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	386					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		CTTCAATCACTGTTCTTTGTA	0.428													6	22					0	0	0	0	G	94750479	G	G	94750479	2	3	160	1	0	0	0	0	0	0	0	1	14152	1567	55	5		5	SERPINA10	14	94750479	Silent	SNP	T	TCGA-CR-7394-01A-11D-2012-08	2125008	94750479	12599061	144	29178											
AHNAK2	113146	broad.mit.edu	37	chr14	105418199	105418199	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatggaggggagactcaCgtcggcctccactttgggtg	6	9	15	11	2	1	1	1	0	0	1	3	3	2	2	2	5	1	1	2	5	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr14:105418199C>T	uc010axc.1	-	7	3709	c.3589G>A	c.(3589-3591)GTG>ATG	p.V1197M	AHNAK2_uc001ypx.2_Missense_Mutation_p.V1097M	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1197						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGAGACTCACGTCGGCCTCC	0.617													11	191					0	0	0	0	T	105418199	T	T	105418199	3	4	160	1	0	0	0	0	1	0	0	0	415	536	19	1	13802	1	AHNAK2	14	105418199	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	10667720	105418199	1931341	145	29179											
MAPKBP1	23005	broad.mit.edu	37	chr15	42067523	42067523	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccggatcaagaatctgttgaGatctccatccatcaaactgc	12	10	7	12	1	4	2	2	1	2	2	6	4	5	3	3	1	2	1	3	1	3	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr15:42067523G>A	uc001zok.3	+	2	336	c.50G>A	c.(49-51)AGA>AAA	p.R17K	MAPKBP1_uc001zoj.3_Missense_Mutation_p.R17K|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.R17K|MAPKBP1_uc010udb.1_5'UTR|MAPKBP1_uc010bck.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	17										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		AATCTGTTGAGATCTCCATCC	0.542													9	70					0	0	0	0	A	42067523	A	A	42067523	3	1	160	1	0	0	0	0	1	0	0	0	9345	942	33	2	52	2	MAPKBP1	15	42067523	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08		42067523	60463869	146	29180											
NEDD4	4734	broad.mit.edu	37	chr15	56144728	56144728	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctggtggtaatccagatGaagtaggcaaaagctaaagt	16	8	11	6	0	0	2	0	1	0	1	1	2	1	2	2	3	2	4	2	3	8	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr15:56144728G>A	uc002adj.2	-	9	2597	c.2297C>T	c.(2296-2298)TCA>TTA	p.S766L	NEDD4_uc002adl.2_Missense_Mutation_p.S347L|NEDD4_uc002adi.2_Missense_Mutation_p.S694L|NEDD4_uc010ugj.1_Missense_Mutation_p.S750L|NEDD4_uc010bfm.2_Missense_Mutation_p.S749L|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	766	Mediates interaction with TNIK (By similarity).				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		TAATCCAGATGAAGTAGGCAA	0.269													4	46					0	0	0	0	A	56144728	A	A	56144728	3	1	160	1	0	0	0	0	1	0	0	0	10364	1294	45	2	1730	2	NEDD4	15	56144728	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	14077205	56144728	46386664	147	29181											
IQCH	64799	broad.mit.edu	37	chr15	67629376	67629376	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacggttctgccatcttctCattgcacagatccctatttc	7	15	5	14	1	4	1	2	0	3	1	7	1	5	1	2	1	2	2	2	1	1	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr15:67629376C>A	uc002aqo.1	+	5	498	c.451C>A	c.(451-453)CAT>AAT	p.H151N	IQCH_uc010ujv.1_Intron|IQCH_uc002aqn.1_Intron|IQCH_uc002aqq.1_Intron|IQCH_uc002aqp.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	151										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		GCCATCTTCTCATTGCACAGA	0.368													12	99					0.00136819	0.00145941	1	0	A	67629376	A	A	67629376	3	1	160	1	0	0	0	0	1	0	0	0	7850	826	29	2	597	2	IQCH	15	67629376	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	11484648	67629376	34902016	148	29182											
ADAMTS7	11173	broad.mit.edu	37	chr15	79092834	79092834	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaggaaggagccccccgcGtcgactcgaaccgggtgcac	9	3	14	15	5	0	0	0	0	0	0	2	5	0	2	4	3	3	1	4	3	2	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr15:79092834G>A	uc002bej.3	-	2	367	c.156C>T	c.(154-156)GAC>GAT	p.D52D	ADAMTS7_uc010und.1_Silent_p.D52D|ADAMTS7_uc002bek.1_Silent_p.D52D	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	52					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						AGCCCCCCGCGTCGACTCGAA	0.677													3	20					0	0	0	0	A	79092834	A	A	79092834	2	1	160	1	0	0	0	0	0	0	0	1	271	1136	40	1		1	ADAMTS7	15	79092834	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	11463458	79092834	23438558	149	29183											
CRTC3	64784	broad.mit.edu	37	chr15	91172509	91172509	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctccatccaagccacgctCaataagactgtgctttcctc	9	10	5	17	1	1	1	1	0	0	1	5	1	4	1	5	0	2	2	5	0	3	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr15:91172509C>T	uc002bpp.2	+	11	1117	c.1011C>T	c.(1009-1011)CTC>CTT	p.L337L	CRTC3_uc002bpo.2_Silent_p.L337L	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	337					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			AAGCCACGCTCAATAAGACTG	0.448			T	MAML2	salivary gland mucoepidermoid								17	126					0	0	0	0	T	91172509	T	T	91172509	2	4	160	1	0	0	0	0	0	0	0	1	3916	813	29	2		2	CRTC3	15	91172509	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	12079675	91172509	11358883	150	29184											
ACSM2B	348158	broad.mit.edu	37	chr16	20554519	20554519	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatacccatcttcatctttGattccccggtctccaaggag	10	12	6	13	1	4	1	1	1	3	0	6	2	5	2	4	2	1	0	4	2	3	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr16:20554519G>C	uc002dhj.3	-	12	1557	c.1347C>G	c.(1345-1347)ATC>ATG	p.I449M	ACSM2B_uc002dhk.3_Missense_Mutation_p.I449M|ACSM2B_uc010bwf.1_Missense_Mutation_p.I449M	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	449					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CTTCATCTTTGATTCCCCGGT	0.498													15	262					0	0	0	0	C	20554519	C	C	20554519	3	2	160	1	0	0	0	0	1	0	0	0	184	1280	45	2	402	2	ACSM2B	16	20554519	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08		20554519	69800234	151	29185											
ARMC5	79798	broad.mit.edu	37	chr16	31477278	31477278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaggaccgagtggcctgcGcgctgaccctgcccttcatc	5	8	12	16	3	1	2	1	2	0	0	2	4	1	3	4	2	2	1	4	2	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr16:31477278G>A	uc002ecc.2	+	5	2501	c.1972G>A	c.(1972-1974)GCG>ACG	p.A658T	ARMC5_uc010vfn.1_Missense_Mutation_p.A753T|ARMC5_uc010vfo.1_Missense_Mutation_p.A690T|ARMC5_uc002eca.3_3'UTR|ARMC5_uc010vfp.1_Missense_Mutation_p.A466T|ARMC5_uc002ecb.2_Missense_Mutation_p.A658T	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	658							binding			pancreas(1)	1						AGTGGCCTGCGCGCTGACCCT	0.652													12	71					0	0	0	0	A	31477278	A	A	31477278	3	1	160	1	0	0	0	0	1	0	0	0	956	1087	38	1	2304	1	ARMC5	16	31477278	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	10922759	31477278	58877475	152	29186											
ACAP1	9744	broad.mit.edu	37	chr17	7253489	7253489	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggggagctgatctgggggctCgagactctgaaggcagggac	8	6	19	8	1	2	3	0	2	2	1	3	6	2	5	0	6	1	3	0	6	1	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:7253489C>G	uc002ggd.2	+	20	2211	c.2005C>G	c.(2005-2007)CGA>GGA	p.R669G	KCTD11_uc002gge.3_5'Flank	NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	669	Required for interaction with GULP1.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						TCTGGGGGCTCGAGACTCTGA	0.637													8	113					0	0	0	0	G	7253489	G	G	7253489	3	3	160	1	0	0	0	0	1	0	0	0	118	876	31	3	2083	3	ACAP1	17	7253489	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08		7253489	73941721	153	29187											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	12	6	8	15	2	1	0	1	0	0	0	3	1	3	1	3	2	2	4	3	2	2	1	rs28934576	by1000genomes	TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	31					0	0	0	0	T	7577120	T	T	7577120	3	4	160	1	0	0	0	0	1	0	0	0	16448	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	323631	7577120	73618090	154	29188											
CYB5D1	124637	broad.mit.edu	37	chr17	7761549	7761549	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaacataacaggcccgaaGacctctgggtatcttacctg	11	8	8	14	1	2	1	0	0	2	1	2	2	2	1	4	2	3	1	4	2	5	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:7761549G>A	uc002gjb.3	+	1	486	c.97G>A	c.(97-99)GAC>AAC	p.D33N	LSMD1_uc002giz.2_5'Flank|LSMD1_uc002gja.2_5'Flank|CYB5D1_uc010cnn.1_Missense_Mutation_p.D33N	NM_144607	NP_653208	Q6P9G0	CB5D1_HUMAN	cytochrome b5 domain containing 1	33	Cytochrome b5 heme-binding.						heme binding			skin(1)	1		all_cancers(10;0.11)|Prostate(122;0.219)				CAGGCCCGAAGACCTCTGGGT	0.617											OREG0024147	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	95					0	0	0	0	A	7761549	A	A	7761549	3	1	160	1	0	0	0	0	1	0	0	0	4141	942	33	2	99	2	CYB5D1	17	7761549	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	184429	7761549	73433661	155	29189											
FLCN	201163	broad.mit.edu	37	chr17	17120452	17120452	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagatcacctggttccccatGagaacgtgccaggccagcat	10	7	10	14	1	1	2	1	1	0	2	2	3	2	2	5	2	3	2	5	2	1	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:17120452G>A	uc002gra.3	-	10	1611	c.1107C>T	c.(1105-1107)CTC>CTT	p.L369L	PLD6_uc010cpn.2_RNA	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	369					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						GGTTCCCCATGAGAACGTGCC	0.522									Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				5	36					0	0	0	0	A	17120452	A	A	17120452	2	1	160	1	0	0	0	0	0	0	0	1	5953	1277	45	2		2	FLCN	17	17120452	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	9358903	17120452	64074758	156	29190											
FAM83G	644815	broad.mit.edu	37	chr17	18881375	18881375	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tatggtctgtcccattctggGgagcttcctctttggggagc	4	14	13	10	0	3	0	0	0	3	0	5	2	5	2	2	5	2	1	2	5	1	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:18881375G>A	uc002guw.2	-	5	1771	c.1604C>T	c.(1603-1605)CCC>CTC	p.P535L	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	535										ovary(1)|central_nervous_system(1)	2						CCCATTCTGGGGAGCTTCCTC	0.647													6	110					0	0	0	0	A	18881375	A	A	18881375	3	1	160	1	0	0	0	0	1	0	0	0	5671	1232	43	4	875	4	FAM83G	17	18881375	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	1760923	18881375	62313835	157	29191											
NF1	4763	broad.mit.edu	37	chr17	29559140	29559140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagtttcacttctagctggtCtccctctgcagcctgaagaa	8	13	8	12	0	4	2	1	1	3	1	5	2	4	2	2	1	3	3	2	1	4	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:29559140C>T	uc002hgg.2	+	25	3580	c.3247C>T	c.(3247-3249)CTC>TTC	p.L1083F	NF1_uc002hgh.2_Missense_Mutation_p.L1083F|NF1_uc010csn.1_Missense_Mutation_p.L943F|NF1_uc002hgi.1_Missense_Mutation_p.L116F	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1083					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCTAGCTGGTCTCCCTCTGCA	0.353			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			4	24					0	0	0	0	T	29559140	T	T	29559140	3	4	160	1	0	0	0	0	1	0	0	0	10410	913	32	2	3406	2	NF1	17	29559140	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	10677765	29559140	51636070	158	29192											
MYO1D	4642	broad.mit.edu	37	chr17	31094700	31094700	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatacactgtttggatctccTcaggtttgaagccaatgact	10	14	8	9	0	2	2	1	2	1	0	3	3	2	3	2	2	2	2	2	2	4	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:31094700T>A	uc002hho.1	-	7	797	c.785A>T	c.(784-786)GAG>GTG	p.E262V	MYO1D_uc002hhp.1_Missense_Mutation_p.E262V|MYO1D_uc010wcb.1_Missense_Mutation_p.E262V	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	262	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			TTGGATCTCCTCAGGTTTGAA	0.423													6	43					0	0	0	0	A	31094700	A	A	31094700	3	1	160	1	0	0	0	0	1	0	0	0	10124	1551	54	5	2299	5	MYO1D	17	31094700	Missense_Mutation	SNP	T	TCGA-CR-7394-01A-11D-2012-08	1535560	31094700	50100510	159	29193											
LPO	4025	broad.mit.edu	37	chr17	56320355	56320355	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcagtgatgagggtccttctCcatctcccagccctcctggc	5	11	9	16	0	3	2	1	2	2	0	7	2	5	2	5	2	1	0	5	2	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:56320355C>G	uc002ivt.2	+	2	331	c.15C>G	c.(13-15)CTC>CTG	p.L5L	LPO_uc010dco.2_Silent_p.L5L|LPO_uc010wnr.1_Silent_p.L5L|LPO_uc010wns.1_5'UTR|LPO_uc010dcp.2_Silent_p.L5L	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	5					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						GGGTCCTTCTCCATCTCCCAG	0.483													11	195					0	0	0	0	G	56320355	G	G	56320355	2	3	160	1	0	0	0	0	0	0	0	1	8972	842	30	2		2	LPO	17	56320355	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	25225655	56320355	24874855	160	29194											
TLK2	11011	broad.mit.edu	37	chr17	60598197	60598197	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcggatccttgagtgataaaGaagtagaggtaagaagctat	15	10	12	4	1	0	5	0	2	0	3	2	6	1	6	1	2	1	3	1	2	7	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:60598197G>C	uc010ddp.2	+	3	413	c.145G>C	c.(145-147)GAA>CAA	p.E49Q	TLK2_uc002izx.3_5'UTR|TLK2_uc002izz.3_Missense_Mutation_p.E49Q|TLK2_uc002jaa.3_Missense_Mutation_p.E49Q|TLK2_uc010wpd.1_Missense_Mutation_p.E49Q	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	49					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						GAGTGATAAAGAAGTAGAGGT	0.274													6	79					0	0	0	0	C	60598197	C	C	60598197	3	2	160	1	0	0	0	0	1	0	0	0	16010	943	33	2	151	2	TLK2	17	60598197	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	4277842	60598197	20597013	161	29195											
SOX9	6662	broad.mit.edu	37	chr17	70120527	70120527	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacacagctcactcgaccttGaggaggcctcccacgaaggg	10	5	11	15	2	1	1	1	1	0	0	3	4	2	2	3	3	1	1	3	3	1	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:70120527G>A	uc002jiw.2	+	3	1901	c.1529G>A	c.(1528-1530)TGA>TAA	p.*510*		NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	510					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			ACTCGACCTTGAGGAGGCCTC	0.552													5	80					0	0	0	0	A	70120527	A	A	70120527	2	1	160	1	0	0	0	0	0	0	0	1	15022	1285	45	2		2	SOX9	17	70120527	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	9522330	70120527	11074683	162	29196											
ITGB4	3691	broad.mit.edu	37	chr17	73729739	73729739	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttctgcgagtatgacaacttCcagtgtccccgcacttccgg	7	11	9	14	3	1	1	0	1	1	0	4	2	4	1	4	1	2	2	4	1	2	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:73729739C>T	uc002jpg.2	+	13	1810	c.1623C>T	c.(1621-1623)TTC>TTT	p.F541F	ITGB4_uc002jph.2_Silent_p.F541F|ITGB4_uc010dgo.2_Silent_p.F541F|ITGB4_uc002jpi.3_Silent_p.F541F|ITGB4_uc010dgp.1_Silent_p.F541F|ITGB4_uc002jpj.2_Silent_p.F541F|ITGB4_uc010wsh.1_Silent_p.F96F	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	541	II.|Extracellular (Potential).|Cysteine-rich tandem repeats.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			ATGACAACTTCCAGTGTCCCC	0.612													4	42					0	0	0	0	T	73729739	T	T	73729739	2	4	160	1	0	0	0	0	0	0	0	1	7936	854	30	2		2	ITGB4	17	73729739	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	3609212	73729739	7465471	163	29197											
QRICH2	84074	broad.mit.edu	37	chr17	74287504	74287504	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaatcatgactgtcaaagaGagagaaagcatggccatgct	15	8	11	7	0	2	4	2	2	0	2	2	6	2	4	1	1	2	2	1	1	3	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:74287504G>A	uc002jrd.1	-	4	2986	c.2806C>T	c.(2806-2808)CTC>TTC	p.L936F	QRICH2_uc010wsz.1_Missense_Mutation_p.L862F|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	936							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						CTGTCAAAGAGAGAGAAAGCA	0.507													6	58					0	0	0	0	A	74287504	A	A	74287504	3	1	160	1	0	0	0	0	1	0	0	0	12945	942	33	2	2249	2	QRICH2	17	74287504	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	557765	74287504	6907706	164	29198											
TNRC6C	57690	broad.mit.edu	37	chr17	76060832	76060832	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggggagaaatgcctaatGttcactcaaagactgaaaac	15	8	10	8	0	2	3	2	1	0	2	2	4	2	3	1	2	2	2	1	2	5	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr17:76060832G>A	uc002jud.2	+	5	3025	c.2425G>A	c.(2425-2427)GTT>ATT	p.V809I	TNRC6C_uc002juf.2_Missense_Mutation_p.V806I|TNRC6C_uc002jue.2_Missense_Mutation_p.V806I	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	809	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AATGCCTAATGTTCACTCAAA	0.458													6	68					0	0	0	0	A	76060832	A	A	76060832	3	1	160	1	0	0	0	0	1	0	0	0	16408	1377	48	4	2431	4	TNRC6C	17	76060832	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	1773328	76060832	5134378	165	29199											
KIAA0802	23255	broad.mit.edu	37	chr18	8718593	8718593	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaaagcctgaaagtggctGagacgggtcaggtggatggt	12	7	17	5	1	1	3	1	2	0	2	1	5	1	4	1	5	1	1	1	5	3	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr18:8718593G>C	uc002knr.2	+	3	287	c.145G>C	c.(145-147)GAG>CAG	p.E49Q	KIAA0802_uc002knq.2_Missense_Mutation_p.E49Q	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	400											0						GAAAGTGGCTGAGACGGGTCA	0.577													8	57					0	0	0	0	C	8718593	C	C	8718593	3	2	160	1	0	0	0	0	1	0	0	0	8233	1291	45	2	147	2	KIAA0802	18	8718593	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08		8718593	69358655	166	29200											
VAPA	9218	broad.mit.edu	37	chr18	9931855	9931855	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcttaaattgcgaaatccatCggatagaaaagtgtgtttca	14	13	8	6	2	2	1	1	0	1	1	4	3	3	2	1	1	1	1	1	1	6	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr18:9931855C>G	uc002kok.2	+	2	427	c.128C>G	c.(127-129)TCG>TGG	p.S43W	VAPA_uc002koj.2_Missense_Mutation_p.S43W	NM_194434	NP_919415	Q9P0L0	VAPA_HUMAN	vesicle-associated membrane protein-associated	43	Cytoplasmic (Potential).|MSP.				cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity				0						CGAAATCCATCGGATAGAAAA	0.393													4	90					0	0	0	0	G	9931855	G	G	9931855	3	3	160	1	0	0	0	0	1	0	0	0	17189	893	31	3	134	3	VAPA	18	9931855	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	1213262	9931855	68145393	167	29201											
ZNF521	25925	broad.mit.edu	37	chr18	22805793	22805793	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaattgcttgtcacaactctCacagatgtaatacgttgaag	13	12	8	8	1	2	2	2	1	1	1	3	3	2	2	0	0	3	3	0	0	5	5			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr18:22805793C>A	uc002kvk.2	-	4	2336	c.2089G>T	c.(2089-2091)GAG>TAG	p.E697*	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Nonsense_Mutation_p.E697*|ZNF521_uc002kvl.2_Nonsense_Mutation_p.E477*	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	697	C2H2-type 16.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCACAACTCTCACAGATGTAA	0.453			T	PAX5	ALL								8	111					0.00307968	0.00327136	1	0	A	22805793	A	A	22805793	4	1	160	1	0	0	0	0	0	1	0	0	18032	835	29	2	1866	2	ZNF521	18	22805793	Nonsense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	12873938	22805793	55271455	168	29202											
CELF4	56853	broad.mit.edu	37	chr18	34833849	34833849	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgccgatctggaagccgttCatggcctggatggcggtctg	6	10	15	10	3	3	0	1	0	2	0	3	3	3	2	3	5	2	1	3	5	1	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr18:34833849C>T	uc002lae.2	-	12	1782	c.1386G>A	c.(1384-1386)ATG>ATA	p.M462I	CELF4_uc010dnd.1_Missense_Mutation_p.M460I|CELF4_uc002lag.2_Missense_Mutation_p.M424I|CELF4_uc002laf.2_Missense_Mutation_p.M456I	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	462	RRM 3.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						GGAAGCCGTTCATGGCCTGGA	0.632													9	75					0	0	0	0	T	34833849	T	T	34833849	3	4	160	1	0	0	0	0	1	0	0	0	3233	826	29	2	78	2	CELF4	18	34833849	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	12028056	34833849	43243399	169	29203											
HMHA1	23526	broad.mit.edu	37	chr19	1073166	1073166	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacctccttgaggcccgccGcccgcgggcccacgagtgcc	5	4	13	19	5	0	2	0	1	0	1	1	3	1	2	7	2	1	0	7	2	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:1073166G>A	uc002lqz.1	+	3	671	c.440G>A	c.(439-441)CGC>CAC	p.R147H	HMHA1_uc010xgd.1_Missense_Mutation_p.R163H|HMHA1_uc010xge.1_5'UTR|HMHA1_uc002lra.1_5'UTR|HMHA1_uc002lrb.1_Missense_Mutation_p.R30H	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	147					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGCCCGCCGCCCGCGGGCC	0.647													8	89					0	0	0	0	A	1073166	A	A	1073166	3	1	160	1	0	0	0	0	1	0	0	0	7279	1087	38	1	450	1	HMHA1	19	1073166	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08		1073166	58055817	170	29204											
PTPRS	5802	broad.mit.edu	37	chr19	5212212	5212212	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctctggcttgatccgctCaagcatggcgtcgatgacga	7	11	11	12	4	2	2	1	2	1	0	5	4	3	2	1	2	1	3	1	2	1	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:5212212C>G	uc002mbv.2	-	32	5053	c.4819G>C	c.(4819-4821)GAG>CAG	p.E1607Q	PTPRS_uc002mbu.1_Missense_Mutation_p.E1176Q|PTPRS_uc010xin.1_Missense_Mutation_p.E1149Q|PTPRS_uc002mbw.2_Missense_Mutation_p.E1569Q|PTPRS_uc002mbx.2_Missense_Mutation_p.E1164Q|PTPRS_uc002mby.2_Missense_Mutation_p.E1160Q	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1607	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TTGATCCGCTCAAGCATGGCG	0.622													4	84					0	0	0	0	G	5212212	G	G	5212212	3	3	160	1	0	0	0	0	1	0	0	0	12876	835	29	2	1055	2	PTPRS	19	5212212	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	4139046	5212212	53916771	171	29205											
ICAM1	3383	broad.mit.edu	37	chr19	10394872	10394872	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccacagtcacctatggcaaCgactccttctcggccaaggc	9	7	8	17	2	2	0	1	0	1	0	4	1	3	0	4	3	1	1	4	3	3	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:10394872C>T	uc002mnq.2	+	4	1120	c.801C>T	c.(799-801)AAC>AAT	p.N267N	ICAM1_uc010xle.1_Silent_p.N45N|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	267	Ig-like C2-type 3.|Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	CCTATGGCAACGACTCCTTCT	0.632													9	77					0	0	0	0	T	10394872	T	T	10394872	2	4	160	1	0	0	0	0	0	0	0	1	7518	535	19	1		1	ICAM1	19	10394872	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	5182660	10394872	48734111	172	29206											
ZNF44	51710	broad.mit.edu	37	chr19	12384320	12384320	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttacattcatacggtttCtccccagtgtgtattttttc	6	19	6	10	1	2	0	1	0	1	0	4	0	2	0	2	1	3	3	2	1	3	8			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:12384320C>T	uc010xmj.1	-	5	1099	c.894G>A	c.(892-894)GAG>GAA	p.E298E	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Silent_p.E250E	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	298					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		CATACGGTTTCTCCCCAGTGT	0.393													10	147					0	0	0	0	T	12384320	T	T	12384320	2	4	160	1	0	0	0	0	0	0	0	1	17979	912	32	2		2	ZNF44	19	12384320	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	1989448	12384320	46744663	173	29207											
NANOS3	342977	broad.mit.edu	37	chr19	13991286	13991286	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccgggaagtctgagccttCgccctcctgctctccctcca	4	10	9	18	2	2	1	0	1	2	0	6	2	4	2	6	1	3	1	6	1	1	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:13991286C>T	uc002mxj.3	+	2	661	c.548C>T	c.(547-549)TCG>TTG	p.S183L		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3	164					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			TCTGAGCCTTCGCCCTCCTGC	0.612											OREG0025300	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	54					0	0	0	0	T	13991286	T	T	13991286	3	4	160	1	0	0	0	0	1	0	0	0	10206	893	31	1	554	1	NANOS3	19	13991286	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	1606966	13991286	45137697	174	29208											
PKN1	5585	broad.mit.edu	37	chr19	14569134	14569134	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaggatttcttggacaatGagaggcatgaggtgcagctg	10	10	16	5	0	1	2	0	2	1	1	1	6	1	5	0	5	2	3	0	5	1	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:14569134G>C	uc002myp.2	+	9	1534	c.1366G>C	c.(1366-1368)GAG>CAG	p.E456Q	PKN1_uc002myq.2_Missense_Mutation_p.E462Q	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	456	C2.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8						CTTGGACAATGAGAGGCATGA	0.582													4	58					0	0	0	0	C	14569134	C	C	14569134	3	2	160	1	0	0	0	0	1	0	0	0	12034	1291	45	2	1443	2	PKN1	19	14569134	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	577848	14569134	44559849	175	29209											
HAUS5	23354	broad.mit.edu	37	chr19	36113850	36113850	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctgccccagtggcggctGcgctgggttcaggcccaggg	3	7	16	15	2	1	0	1	0	0	0	2	0	2	0	4	5	2	3	4	5	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:36113850G>A	uc002oam.1	+	19	1908	c.1857G>A	c.(1855-1857)CTG>CTA	p.L619L		NM_015302	NP_056117	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	619					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle					0						AGTGGCGGCTGCGCTGGGTTC	0.652													14	62					0	0	0	0	A	36113850	A	A	36113850	2	1	160	1	0	0	0	0	0	0	0	1	7008	1306	46	4		4	HAUS5	19	36113850	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	21544716	36113850	23015133	176	29210											
SAMD4B	55095	broad.mit.edu	37	chr19	39867397	39867397	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgagcatccagaagctgcGtgagagacagagcgtcctca	11	6	12	12	2	1	5	1	2	0	3	3	6	3	5	3	0	4	2	3	0	1	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:39867397G>A	uc002olb.2	+	9	2105	c.1070G>A	c.(1069-1071)CGT>CAT	p.R357H	SAMD4B_uc002ola.2_Missense_Mutation_p.R357H	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	357	SAM.						protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CAGAAGCTGCGTGAGAGACAG	0.557													8	36					0	0	0	0	A	39867397	A	A	39867397	3	1	160	1	0	0	0	0	1	0	0	0	13887	1145	40	1	1088	1	SAMD4B	19	39867397	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	3753547	39867397	19261586	177	29211											
TIMM50	92609	broad.mit.edu	37	chr19	39971230	39971230	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ataagtgtgatcccttccttCgctgcgtcctttgcaggggc	5	13	11	12	2	0	1	0	1	0	0	4	1	3	1	3	2	2	2	3	2	1	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:39971230C>T	uc002olu.1	+	1	179	c.46C>T	c.(46-48)CGC>TGC	p.R16C	TIMM50_uc002olt.1_RNA	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50	Error:Variant_position_missing_in_Q3ZCQ8_after_alignment					mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			ovary(1)	1	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TCCCTTCCTTCGCTGCGTCCT	0.562													8	82					0	0	0	0	T	39971230	T	T	39971230	3	4	160	1	0	0	0	0	1	0	0	0	15979	884	31	1	48	1	TIMM50	19	39971230	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	103833	39971230	19157753	178	29212											
CD177	57126	broad.mit.edu	37	chr19	43865665	43865665	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaacctgttcaagtggcTccccccgaatgacctgcccc	7	9	9	16	1	1	1	1	1	0	0	2	3	2	2	7	2	2	2	7	2	3	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:43865665T>C	uc002owi.2	+	9	1057	c.1015T>C	c.(1015-1017)TCC>CCC	p.S339P	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	339	UPAR/Ly6 2.				blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				TTCAAGTGGCTCCCCCCGAAT	0.547													3	40					0	0	0	0	C	43865665	C	C	43865665	3	2	160	1	0	0	0	0	1	0	0	0	2986	1551	54	5	1045	5	CD177	19	43865665	Missense_Mutation	SNP	T	TCGA-CR-7394-01A-11D-2012-08	3894435	43865665	15263318	179	29213											
ZNF225	7768	broad.mit.edu	37	chr19	44635574	44635574	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaatgtgggaaggccttCattcatgattcccagcttca	11	11	10	9	0	3	2	3	1	0	1	4	4	4	3	2	2	1	1	2	2	2	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:44635574C>A	uc002oyj.1	+	5	1050	c.807C>A	c.(805-807)TTC>TTA	p.F269L	ZNF225_uc010eje.1_Missense_Mutation_p.F186L|ZNF225_uc010ejf.1_Missense_Mutation_p.F269L	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	269	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				GGAAGGCCTTCATTCATGATT	0.408													10	88					0.00621372	0.00651931	1	0	A	44635574	A	A	44635574	3	1	160	1	0	0	0	0	1	0	0	0	17846	825	29	2	821	2	ZNF225	19	44635574	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	769909	44635574	14493409	180	29214											
APOC1	341	broad.mit.edu	37	chr19	45419544	45419544	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacaaggctcgggaactcatCagccgcatcaaacagagtga	14	5	11	11	2	3	2	3	1	0	1	4	4	3	3	1	2	3	2	1	2	3	0			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:45419544C>G	uc002pac.1	+	4	408	c.156C>G	c.(154-156)ATC>ATG	p.I52M	APOC1_uc002pad.1_Missense_Mutation_p.I52M|APOC1_uc002pae.1_Missense_Mutation_p.I52M|APOC1_uc002paf.1_RNA	NM_001645	NP_001636	P02654	APOC1_HUMAN	apolipoprotein C-I precursor	52					cholesterol efflux|chylomicron remnant clearance|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol transport|negative regulation of fatty acid biosynthetic process|negative regulation of lipoprotein lipase activity|negative regulation of phosphatidylcholine catabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of very-low-density lipoprotein particle clearance|phospholipid efflux|positive regulation of cholesterol esterification|very-low-density lipoprotein particle assembly|very-low-density lipoprotein particle clearance	chylomicron|endoplasmic reticulum|high-density lipoprotein particle|very-low-density lipoprotein particle	fatty acid binding|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipase inhibitor activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)		GGGAACTCATCAGCCGCATCA	0.587													8	95					0	0	0	0	G	45419544	G	G	45419544	3	3	160	1	0	0	0	0	1	0	0	0	797	816	29	2	162	2	APOC1	19	45419544	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	783970	45419544	13709439	181	29215											
OPA3	80207	broad.mit.edu	37	chr19	46057068	46057068	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtggcttcgcccagcagctCtgcgcccagctcagctgccg	4	7	13	17	3	2	0	1	0	1	0	3	0	2	0	3	2	6	5	3	2	0	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:46057068C>G	uc002pck.3	-	2	344	c.244G>C	c.(244-246)GAG>CAG	p.E82Q	OPA3_uc002pcj.3_Intron|OPA3_uc010xxk.1_Missense_Mutation_p.E29Q	NM_025136	NP_079412	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform b	82					response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		CCCAGCAGCTCTGCGCCCAGC	0.657													7	30					0	0	0	0	G	46057068	G	G	46057068	3	3	160	1	0	0	0	0	1	0	0	0	10926	922	32	2	704	2	OPA3	19	46057068	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	637524	46057068	13071915	182	29216											
OPA3	80207	broad.mit.edu	37	chr19	46057095	46057095	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagctcagctgccgcctcctCgttcagcggcttgatgaccg	5	9	11	16	4	2	2	2	2	0	0	4	2	3	2	4	1	4	4	4	1	0	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:46057095C>T	uc002pck.3	-	2	317	c.217G>A	c.(217-219)GAG>AAG	p.E73K	OPA3_uc002pcj.3_Intron|OPA3_uc010xxk.1_Missense_Mutation_p.E20K	NM_025136	NP_079412	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform b	73					response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		GCCGCCTCCTCGTTCAGCGGC	0.657													5	30					0	0	0	0	T	46057095	T	T	46057095	3	4	160	1	0	0	0	0	1	0	0	0	10926	893	31	1	731	1	OPA3	19	46057095	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	27	46057095	13071888	183	29217											
LILRB1	10859	broad.mit.edu	37	chr19	55143593	55143593	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccgtgggccccgtgagccCgagtcgcaggtggtggtaca	5	7	16	13	4	0	1	0	1	0	0	2	2	1	1	4	4	2	2	4	4	1	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:55143593C>T	uc002qgj.2	+	6	906	c.566C>T	c.(565-567)CCG>CTG	p.P189L	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.P189L|LILRB1_uc002qgk.2_Missense_Mutation_p.P189L|LILRB1_uc002qgm.2_Missense_Mutation_p.P189L|LILRB1_uc010erq.2_Missense_Mutation_p.P189L|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	189	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CCCGTGAGCCCGAGTCGCAGG	0.592										HNSCC(37;0.09)			17	147					0	0	0	0	T	55143593	T	T	55143593	3	4	160	1	0	0	0	0	1	0	0	0	8831	652	23	1	580	1	LILRB1	19	55143593	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	9086498	55143593	3985390	184	29218											
NLRP7	199713	broad.mit.edu	37	chr19	55450785	55450785	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaactgctggaagctgaggtGgatgaaggagtagcagcctt	12	8	15	6	0	0	2	0	2	0	0	0	5	0	5	1	4	5	4	1	4	4	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:55450785G>A	uc002qih.3	-	4	1478	c.1402C>T	c.(1402-1404)CAC>TAC	p.H468Y	NLRP7_uc002qig.3_Missense_Mutation_p.H468Y|NLRP7_uc002qii.3_Missense_Mutation_p.H468Y|NLRP7_uc010esk.2_Missense_Mutation_p.H468Y|NLRP7_uc010esl.2_Missense_Mutation_p.H496Y	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	468	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AAGCTGAGGTGGATGAAGGAG	0.622													3	40					0	0	0	0	A	55450785	A	A	55450785	3	1	160	1	0	0	0	0	1	0	0	0	10536	1348	47	4	1743	4	NLRP7	19	55450785	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	307192	55450785	3678198	185	29219											
ZSCAN1	284312	broad.mit.edu	37	chr19	58564809	58564809	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccacagggtcccgggcccGcttgcctctgaagccgagta	6	7	12	16	3	1	1	0	1	1	0	3	2	3	1	5	2	2	2	5	2	2	2	rs149388605	byFrequency	TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:58564809G>T	uc002qrc.1	+	6	864	c.617G>T	c.(616-618)CGC>CTC	p.R206L		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	206					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		TCCCGGGCCCGCTTGCCTCTG	0.662													8	76					1.26484e-09	1.38376e-09	1	0	T	58564809	T	T	58564809	3	4	160	1	0	0	0	0	1	0	0	0	18293	1087	38	3	631	3	ZSCAN1	19	58564809	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	3114024	58564809	564174	186	29220											
ZNF544	27300	broad.mit.edu	37	chr19	58773055	58773055	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgtgtaatcagtgtggaaaAtctttcagctgttgtaagct	10	15	11	5	0	3	0	2	0	1	0	3	1	3	1	0	1	2	5	0	1	4	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr19:58773055A>G	uc010euo.2	+	7	1557	c.1083A>G	c.(1081-1083)AAA>AAG	p.K361K	ZNF544_uc010yhw.1_RNA|ZNF544_uc010yhx.1_Silent_p.K333K|ZNF544_uc010yhy.1_Silent_p.K333K|ZNF544_uc002qrt.3_Silent_p.K219K|ZNF544_uc002qru.3_Silent_p.K219K|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	361	C2H2-type 1; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		AGTGTGGAAAATCTTTCAGCT	0.458													8	54					0	0	0	0	G	58773055	G	G	58773055	2	3	160	1	0	0	0	0	0	0	0	1	18044	98	4	5		5	ZNF544	19	58773055	Silent	SNP	A	TCGA-CR-7394-01A-11D-2012-08	208246	58773055	355928	187	29221											
ANGPT4	51378	broad.mit.edu	37	chr20	870886	870886	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtcggtcagcttgcggatCtgggcagtggtctggttcag	5	12	16	8	2	4	0	2	0	2	0	5	1	4	1	0	5	2	3	0	5	0	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr20:870886C>T	uc002wei.2	-	2	538	c.435G>A	c.(433-435)CAG>CAA	p.Q145Q	ANGPT4_uc010zpn.1_Silent_p.Q139Q	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	145	Potential.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						GCTTGCGGATCTGGGCAGTGG	0.622													3	43					0	0	0	0	T	870886	T	T	870886	2	4	160	1	0	0	0	0	0	0	0	1	612	912	32	2		2	ANGPT4	20	870886	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08		870886	62154634	188	29222											
AVP	551	broad.mit.edu	37	chr20	3065205	3065205	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacagtgggaagtacctgtCtcagctccaggtcggacatg	9	8	12	12	1	1	0	1	0	1	0	4	2	2	2	3	3	2	2	3	3	2	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr20:3065205C>G	uc002whu.2	-	1	166	c.116G>C	c.(115-117)AGA>ACA	p.R39T		NM_000490	NP_000481	P01185	NEU2_HUMAN	arginine vasopressin-neurophysin II	39					cell-cell signaling|ERK1 and ERK2 cascade|generation of precursor metabolites and energy|negative regulation of apoptosis|negative regulation of release of cytochrome c from mitochondria|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|protein kinase C signaling cascade|sodium-independent organic anion transport|transmembrane transport|vasoconstriction|water transport	cytosol|soluble fraction	caspase inhibitor activity|neurohypophyseal hormone activity|protein kinase activity|signal transducer activity|V1A vasopressin receptor binding				0				COAD - Colon adenocarcinoma(99;0.00643)		AAGTACCTGTCTCAGCTCCAG	0.642													5	155					0	0	0	0	G	3065205	G	G	3065205	3	3	160	1	0	0	0	0	1	0	0	0	1231	913	32	2	390	2	AVP	20	3065205	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	2194319	3065205	59960315	189	29223											
PLCB4	5332	broad.mit.edu	37	chr20	9317800	9317800	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgtttgaacccaactgcCtcttcaaagtggatgagttt	9	15	9	8	0	2	2	1	2	1	0	2	3	2	3	2	1	3	2	2	1	3	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr20:9317800C>G	uc002wnf.2	+	4	248	c.112C>G	c.(112-114)CTC>GTC	p.L38V	PLCB4_uc010gbw.1_Missense_Mutation_p.L38V|PLCB4_uc010gbx.2_Missense_Mutation_p.L38V|PLCB4_uc002wne.2_Missense_Mutation_p.L38V	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	38					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						ACCCAACTGCCTCTTCAAAGT	0.383													3	75					0	0	0	0	G	9317800	G	G	9317800	3	3	160	1	0	0	0	0	1	0	0	0	12085	681	24	4	118	4	PLCB4	20	9317800	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	6252595	9317800	53707720	190	29224											
BPIL1	80341	broad.mit.edu	37	chr20	31611154	31611154	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttgcccttcagggctacGtggtgatatccagtggactc	6	12	11	12	1	1	1	1	1	0	0	3	2	2	2	3	3	2	1	3	3	2	4	rs142508681		TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr20:31611154G>A	uc002wyj.2	+	16	1536	c.1342G>A	c.(1342-1344)GTG>ATG	p.V448M		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	448						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						TCAGGGCTACGTGGTGATATC	0.517													6	57					0	0	0	0	A	31611154	A	A	31611154	3	1	160	1	0	0	0	0	1	0	0	0	1496	1145	40	1	1400	1	BPIL1	20	31611154	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	22293354	31611154	31414366	191	29225											
TRPM2	7226	broad.mit.edu	37	chr21	45821618	45821618	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccgcgcccgtgccttcttCaccgcacccgtggtggtctt	2	10	11	18	5	3	0	1	0	2	0	3	0	3	0	5	2	1	1	5	2	0	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr21:45821618C>T	uc002zet.1	+	17	2589	c.2376C>T	c.(2374-2376)TTC>TTT	p.F792F	TRPM2_uc002zeu.1_Silent_p.F792F|TRPM2_uc002zew.1_Silent_p.F792F|TRPM2_uc010gpt.1_Silent_p.F792F|TRPM2_uc002zex.1_Silent_p.F578F|TRPM2_uc002zey.1_Silent_p.F305F	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	792	Extracellular (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTGCCTTCTTCACCGCACCCG	0.652													17	193					0	0	0	0	T	45821618	T	T	45821618	2	4	160	1	0	0	0	0	0	0	0	1	16653	825	29	2		2	TRPM2	21	45821618	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08		45821618	2308277	192	29226											
SH3BP1	23616	broad.mit.edu	37	chr22	38041500	38041500	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgtcatgatgctgctttctGagggcatgaaggaagaggtg	9	10	16	6	1	2	4	1	3	1	1	2	5	2	5	0	3	2	3	0	3	2	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr22:38041500G>A	uc003ati.2	+	10	1018	c.907G>A	c.(907-909)GAG>AAG	p.E303K	SH3BP1_uc003atg.1_RNA|SH3BP1_uc011anl.1_Missense_Mutation_p.E303K|SH3BP1_uc003ath.1_Missense_Mutation_p.E303K|SH3BP1_uc003atj.1_Missense_Mutation_p.E239K|SH3BP1_uc003atk.1_Missense_Mutation_p.E217K|uc003atl.1_Intron	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	303	Rho-GAP.				signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GCTGCTTTCTGAGGGCATGAA	0.642													14	85					0	0	0	0	A	38041500	A	A	38041500	3	1	160	1	0	0	0	0	1	0	0	0	14309	1291	45	2	945	2	SH3BP1	22	38041500	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08		38041500	13263066	193	29227											
MGAT3	4248	broad.mit.edu	37	chr22	39884499	39884499	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacggcatccgcctgcgcCgccgccagtactacaccatg	7	6	11	17	5	0	0	0	0	0	0	1	1	1	1	6	2	3	2	6	2	2	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr22:39884499C>G	uc003axv.3	+	2	1386	c.1147C>G	c.(1147-1149)CGC>GGC	p.R383G	MGAT3_uc010gxy.2_Missense_Mutation_p.R383G	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	383	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					CCGCCTGCGCCGCCGCCAGTA	0.657													10	81					0	0	0	0	G	39884499	G	G	39884499	3	3	160	1	0	0	0	0	1	0	0	0	9597	652	23	3	1149	3	MGAT3	22	39884499	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	1842999	39884499	11420067	194	29228											
EP300	2033	broad.mit.edu	37	chr22	41568590	41568590	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atttctggcccaatgttctgGaagaaagcattaaggaactg	13	11	10	7	0	2	1	0	0	2	1	2	3	2	3	1	3	2	2	1	3	5	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr22:41568590G>A	uc003azl.3	+	28	4935	c.4540G>A	c.(4540-4542)GAA>AAA	p.E1514K		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1514					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CAATGTTCTGGAAGAAAGCAT	0.398			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				4	26					0	0	0	0	A	41568590	A	A	41568590	3	1	160	1	0	0	0	0	1	0	0	0	5172	1175	41	2	4650	2	EP300	22	41568590	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	1684091	41568590	9735976	195	29229											
EP300	2033	broad.mit.edu	37	chr22	41574519	41574519	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcgactccttcagcaacaGatggggtcccctgttcagcc	8	8	10	15	1	2	1	2	0	0	1	4	2	4	1	4	2	4	2	4	2	1	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr22:41574519G>A	uc003azl.3	+	31	7199	c.6804G>A	c.(6802-6804)CAG>CAA	p.Q2268Q		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	2268					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TTCAGCAACAGATGGGGTCCC	0.577			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				4	92					0	0	0	0	A	41574519	A	A	41574519	2	1	160	1	0	0	0	0	0	0	0	1	5172	933	33	2		2	EP300	22	41574519	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	5929	41574519	9730047	196	29230											
NAGA	4668	broad.mit.edu	37	chr22	42461814	42461814	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgctccacgaaccaattCaggatggagagcacgctcca	11	7	11	12	2	1	1	1	0	0	1	3	4	3	2	3	3	3	3	3	3	2	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr22:42461814C>T	uc003bbx.2	-	7	824	c.687G>A	c.(685-687)CTG>CTA	p.L229L	NAGA_uc003bby.2_Silent_p.L229L|NAGA_uc003bbw.3_Silent_p.L229L	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	229					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						CGAACCAATTCAGGATGGAGA	0.577													5	55					0	0	0	0	T	42461814	T	T	42461814	2	4	160	1	0	0	0	0	0	0	0	1	10194	813	29	2		2	NAGA	22	42461814	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	887295	42461814	8842752	197	29231											
SMC1B	27127	broad.mit.edu	37	chr22	45802535	45802535	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcttcactgaaattgactCtacagttcccttttaaaaac	12	16	3	10	0	3	2	1	2	2	0	4	2	4	2	1	0	2	1	1	0	5	7			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chr22:45802535C>T	uc003bgc.2	-	4	473	c.421G>A	c.(421-423)GAG>AAG	p.E141K	SMC1B_uc003bgd.2_Missense_Mutation_p.E141K|SMC1B_uc003bge.1_5'UTR	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	141					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GAAATTGACTCTACAGTTCCC	0.318													6	56					0	0	0	0	T	45802535	T	T	45802535	3	4	160	1	0	0	0	0	1	0	0	0	14846	922	32	2	3374	2	SMC1B	22	45802535	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	3340721	45802535	5502031	198	29232											
FAM9A	171482	broad.mit.edu	37	chrX	8759387	8759387	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttcttcactggaagaaaTgatgcaataattgtctttag	13	15	7	6	0	3	2	1	1	2	1	3	3	3	3	0	1	1	1	0	1	5	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:8759387T>G	uc004csg.2	-	9	1075	c.964A>C	c.(964-966)ATT>CTT	p.I322L		NM_174951	NP_777611	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	322						nucleolus					0		Hepatocellular(5;0.219)				CTGGAAGAAATGATGCAATAA	0.348													10	22					0	0	0	0	G	8759387	G	G	8759387	3	3	160	1	0	0	0	0	1	0	0	0	5691	1464	51	5	38	5	FAM9A	23	8759387	Missense_Mutation	SNP	T	TCGA-CR-7394-01A-11D-2012-08		8759387	146511173	199	29233											
MAP7D2	256714	broad.mit.edu	37	chrX	20033405	20033405	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctctctcgagacgcatcTgttcagctacctcccgggcc	5	11	9	16	3	4	1	1	0	3	1	7	2	5	1	3	1	2	4	3	1	1	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:20033405T>G	uc004czr.1	-	11	1581	c.1562A>C	c.(1561-1563)CAG>CCG	p.Q521P	MAP7D2_uc004czq.1_Missense_Mutation_p.Q406P|MAP7D2_uc011mji.1_Missense_Mutation_p.Q469P|MAP7D2_uc010nfo.1_Missense_Mutation_p.Q562P|MAP7D2_uc011mjj.1_Missense_Mutation_p.Q476P	NM_152780	NP_689993	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	521										ovary(2)|breast(1)	3						GAGACGCATCTGTTCAGCTAC	0.458													14	62					0	0	0	0	G	20033405	G	G	20033405	3	3	160	1	0	0	0	0	1	0	0	0	9321	1580	55	5	656	5	MAP7D2	23	20033405	Missense_Mutation	SNP	T	TCGA-CR-7394-01A-11D-2012-08	11274018	20033405	135237155	200	29234											
PHF16	9767	broad.mit.edu	37	chrX	46915504	46915504	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccgaaatctgtgctatatGataagcagacgagagaagct	14	9	11	7	2	1	3	0	1	1	2	2	6	2	3	1	0	3	3	1	0	5	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:46915504G>C	uc004dgx.2	+	10	1515	c.1464G>C	c.(1462-1464)ATG>ATC	p.M488I	PHF16_uc004dgy.2_Missense_Mutation_p.M488I	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	488					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						TGTGCTATATGATAAGCAGAC	0.398													3	24					0	0	0	0	C	46915504	C	C	46915504	3	2	160	1	0	0	0	0	1	0	0	0	11882	1290	45	2	1498	2	PHF16	23	46915504	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	26882099	46915504	108355056	201	29235											
ZMYM3	9203	broad.mit.edu	37	chrX	70470529	70470529	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatggcacaaagtcctcatCattggggtcatctaccatgg	11	10	10	10	0	4	0	3	0	1	0	5	1	5	0	2	4	1	1	2	4	3	2			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:70470529C>T	uc004dzh.1	-	5	913	c.826G>A	c.(826-828)GAT>AAT	p.D276N	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.D276N|ZMYM3_uc004dzj.1_Missense_Mutation_p.D276N|ZMYM3_uc011mpu.1_Missense_Mutation_p.D7N|ZMYM3_uc004dzk.3_Missense_Mutation_p.D276N|ZMYM3_uc004dzl.3_Missense_Mutation_p.D276N|ZMYM3_uc004dzm.3_Missense_Mutation_p.D276N	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	276					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					AAGTCCTCATCATTGGGGTCA	0.567													4	14					0	0	0	0	T	70470529	T	T	70470529	3	4	160	1	0	0	0	0	1	0	0	0	17768	826	29	2	3388	2	ZMYM3	23	70470529	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	23555025	70470529	84800031	202	29236											
ACSL4	2182	broad.mit.edu	37	chrX	108926545	108926545	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgacagagcgatatggActtccaggtttgtctgaagt	9	13	13	6	1	1	3	0	2	1	1	2	5	2	4	1	2	1	1	1	2	2	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:108926545A>G	uc004eoi.2	-	4	676	c.171T>C	c.(169-171)AGT>AGC	p.S57S	ACSL4_uc004eoj.2_Silent_p.S16S|ACSL4_uc004eok.2_Silent_p.S16S|ACSL4_uc010npp.1_Silent_p.S57S	NM_022977	NP_075266	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	57	Cytoplasmic (Potential).				fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(1)|lung(1)|ovary(1)	3					Icosapent(DB00159)|Troglitazone(DB00197)	AGCGATATGGACTTCCAGGTT	0.403													5	190					0	0	0	0	G	108926545	G	G	108926545	2	3	160	1	0	0	0	0	0	0	0	1	179	272	10	5		5	ACSL4	23	108926545	Silent	SNP	A	TCGA-CR-7394-01A-11D-2012-08	38456016	108926545	46344015	203	29237											
AMOT	154796	broad.mit.edu	37	chrX	112048305	112048305	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccagcttctccttctcaCgctggctttctttatctgtc	3	18	5	15	1	4	0	1	0	4	0	8	0	5	0	2	1	1	3	2	1	1	6	rs147627113	byFrequency	TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:112048305C>T	uc004epr.2	-	5	1646	c.1646G>A	c.(1645-1647)CGT>CAT	p.R549H	AMOT_uc004eps.2_Missense_Mutation_p.R140H	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	549	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						CTCCTTCTCACGCTGGCTTTC	0.498													6	158					0	0	0	0	T	112048305	T	T	112048305	3	4	160	1	0	0	0	0	1	0	0	0	582	536	19	1	1636	1	AMOT	23	112048305	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	3121760	112048305	43222255	204	29238											
LRCH2	57631	broad.mit.edu	37	chrX	114357438	114357438	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caatgtcatcaggcaaaattActtttaacctggattcaaga	15	12	6	8	0	3	1	3	0	0	1	3	2	3	2	1	2	2	1	1	2	6	4			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:114357438A>G	uc010nqe.2	-	19	2016	c.1985T>C	c.(1984-1986)GTA>GCA	p.V662A	LRCH2_uc004epz.2_Missense_Mutation_p.V645A	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)	662	CH.									ovary(1)	1						AGGCAAAATTACTTTTAACCT	0.328													3	17					0	0	0	0	G	114357438	G	G	114357438	3	3	160	1	0	0	0	0	1	0	0	0	8983	391	14	5	324	5	LRCH2	23	114357438	Missense_Mutation	SNP	A	TCGA-CR-7394-01A-11D-2012-08	2309133	114357438	40913122	205	29239											
KIAA1210	57481	broad.mit.edu	37	chrX	118220735	118220735	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctcactcttatacttctgCgagggaggggctcttttcag	6	15	10	10	1	5	0	2	0	4	0	6	2	5	1	0	3	2	1	0	3	2	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:118220735C>T	uc004era.3	-	11	4458	c.4458G>A	c.(4456-4458)TCG>TCA	p.S1486S		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1486										ovary(4)|skin(1)	5						TATACTTCTGCGAGGGAGGGG	0.448													3	32					0	0	0	0	T	118220735	T	T	118220735	2	4	160	1	0	0	0	0	0	0	0	1	8253	755	27	1		1	KIAA1210	23	118220735	Silent	SNP	C	TCGA-CR-7394-01A-11D-2012-08	3863297	118220735	37049825	206	29240											
PASD1	139135	broad.mit.edu	37	chrX	150828296	150828296	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagttttcctggatactatgCctgaatctccaggtaggtac	9	13	9	10	0	1	1	0	1	1	0	3	2	2	2	3	3	3	3	3	3	5	6			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:150828296C>T	uc004fev.3	+	10	1161	c.829C>T	c.(829-831)CCT>TCT	p.P277S		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	277						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGATACTATGCCTGAATCTCC	0.383													4	45					0	0	0	0	T	150828296	T	T	150828296	3	4	160	1	0	0	0	0	1	0	0	0	11525	739	26	4	863	4	PASD1	23	150828296	Missense_Mutation	SNP	C	TCGA-CR-7394-01A-11D-2012-08	32607561	150828296	4442264	207	29241											
GABRQ	55879	broad.mit.edu	37	chrX	151821396	151821396	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccatggccccagtgggaaGcccatgcttcaccatggcga	8	6	13	14	1	1	0	1	0	0	0	1	2	1	1	5	4	2	1	5	4	1	1			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:151821396G>T	uc004ffp.1	+	9	1571	c.1551G>T	c.(1549-1551)AAG>AAT	p.K517N		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	517						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGTGGGAAGCCCATGCTTC	0.547													4	60					0.00909568	0.00946542	1	0	T	151821396	T	T	151821396	3	4	160	1	0	0	0	0	1	0	0	0	6209	962	34	4	1585	4	GABRQ	23	151821396	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08	993100	151821396	3449164	208	29242											
SLC6A8	6535	broad.mit.edu	37	chrX	152960239	152960239	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaacacctacgtgtacccGtggtggggtgaggccatggg	9	7	15	10	2	0	1	0	1	0	0	0	1	0	1	3	5	4	1	3	5	4	2	rs149677083	byFrequency	TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrX:152960239G>A	uc004fib.3	+	12	1940	c.1662G>A	c.(1660-1662)CCG>CCA	p.P554P	SLC6A8_uc004fic.3_Silent_p.P544P|SLC6A8_uc011myx.1_Silent_p.P439P|SLC6A8_uc010nuj.2_RNA	NM_005629	NP_005620	P48029	SC6A8_HUMAN	solute carrier family 6 member 8 isoform 1	554	Extracellular (Potential).		P -> L (in XL-CDS).		creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	ACGTGTACCCGTGGTGGGGTG	0.607													8	32					0	0	0	0	A	152960239	A	A	152960239	2	1	160	1	0	0	0	0	0	0	0	1	14754	1132	40	1		1	SLC6A8	23	152960239	Silent	SNP	G	TCGA-CR-7394-01A-11D-2012-08	1138843	152960239	2310321	209	29243											
PCDH11Y	83259	broad.mit.edu	37	chrY	4968225	4968225	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgctgtagtaagatgtcGccaggcaccacaccttaagg	11	8	10	12	1	0	1	0	0	0	1	1	1	0	1	3	2	1	4	3	2	3	3			TCGA-CR-7394-01A-11D-2012-08	TCGA-CR-7394-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1fe9a612-4c9a-432d-b175-e1d8bdbc7c56	0ffafc82-f74d-4ed7-8a93-cf6cb4b4c6ca	g.chrY:4968225G>A	uc004fqo.2	+	2	3340	c.2606G>A	c.(2605-2607)CGC>CAC	p.R869H	PCDH11Y_uc010nwg.1_Missense_Mutation_p.R858H|PCDH11Y_uc004fql.1_Missense_Mutation_p.R858H|PCDH11Y_uc004fqm.1_Missense_Mutation_p.R858H|PCDH11Y_uc004fqn.1_Missense_Mutation_p.R869H|PCDH11Y_uc004fqp.1_Missense_Mutation_p.R640H	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	869	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						GTAAGATGTCGCCAGGCACCA	0.433													22	44					0	0	0	0	A	4968225	A	A	4968225	3	1	160	1	0	0	0	0	1	0	0	0	11563	1087	38	1	2648	1	PCDH11Y	24	4968225	Missense_Mutation	SNP	G	TCGA-CR-7394-01A-11D-2012-08		4968225	54405341	210	29244											
C1orf113	79729	broad.mit.edu	37	chr1	36785434	36785434	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctccccagagaagaccctCactctaggggacaaggcctc	10	5	9	17	0	2	2	1	0	1	2	4	4	3	3	5	3	0	0	5	3	3	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:36785434C>T	uc010oia.1	+	14	1198	c.1170C>T	c.(1168-1170)CTC>CTT	p.L390L	C1orf113_uc010oib.1_Silent_p.L279L|C1orf113_uc010oic.1_RNA|C1orf113_uc009vuz.1_Silent_p.L36L	NM_001162530	NP_001156002	A4FU49	SH321_HUMAN	SH3 domain-containing protein C1orf113 isoform	274											0		Myeloproliferative disorder(586;0.0393)				AGAAGACCCTCACTCTAGGGG	0.617													12	47					0	0	0	0	T	36785434	T	T	36785434	2	4	161	1	0	0	0	0	0	0	0	1	1995	813	29	2		2	C1orf113	1	36785434	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08		36785434	212465187	1	29245											
SLC1A7	6512	broad.mit.edu	37	chr1	53580588	53580588	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaggtagtacgccacggtGaggacgcccaggcggctaga	10	4	15	12	4	0	2	0	1	0	1	0	3	0	3	2	5	1	3	2	5	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:53580588G>A	uc001cuy.2	-	3	441	c.273C>T	c.(271-273)CTC>CTT	p.L91L	SLC1A7_uc001cuz.3_Silent_p.L91L|uc001cva.1_RNA	NM_006671	NP_006662	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter),	91						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|large_intestine(1)	3				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	ACGCCACGGTGAGGACGCCCA	0.647													6	19					0	0	0	0	A	53580588	A	A	53580588	2	1	161	1	0	0	0	0	0	0	0	1	14502	1277	45	2		2	SLC1A7	1	53580588	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	16795154	53580588	195670033	2	29246											
ITGB3BP	23421	broad.mit.edu	37	chr1	63944501	63944502	+	Frame_Shift_Del	DEL	TT	-	-																															ggtgattcaatttttttctcTtttctatatatgtgtaataa																										TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:63944501_63944502delTT	uc001dba.1	-	4	218_219	c.187_188delAA	c.(187-189)AAGfs	p.K63fs	ITGB3BP_uc001dbb.1_Frame_Shift_Del_p.K102fs|ITGB3BP_uc001dbc.1_RNA|ITGB3BP_uc001dbd.1_Intron|ITGB3BP_uc009wak.1_Frame_Shift_Del_p.K85fs	NM_014288	NP_055103	Q13352	CENPR_HUMAN	integrin beta 3 binding protein	63	Nuclear localization signal.			Missing: Abolishes localization to nucleus.|KRK->AAA: Abolishes localization to nucleus.	apoptosis|cell adhesion|CenH3-containing nucleosome assembly at centromere|induction of apoptosis by extracellular signals|mitotic prometaphase|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome, centromeric region|cytosol|membrane fraction|nucleoplasm	protein C-terminus binding|signal transducer activity				0						TTTTTTTCTCTTTTCTATATAT	0.228													---	---	---								-	63944502	-	-	63944501	7	5	161	1	0	1	0	1	0	0	0	0	7935	1609	56	0	365	0	ITGB3BP	1	63944501	Frame_Shift_Del	DEL	TT	TCGA-CR-7395-01A-11D-2012-08	10363913	63944501	185306120	3	29247											
CACHD1	57685	broad.mit.edu	37	chr1	65142628	65142628	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgacatacacagctattgAccctggcctgcaagatgctc	10	9	10	12	0	0	3	0	2	0	1	1	3	0	3	2	2	4	3	2	2	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:65142628A>G	uc001dbo.1	+	22	2978	c.2873A>G	c.(2872-2874)GAC>GGC	p.D958G	CACHD1_uc001dbp.1_Missense_Mutation_p.D713G|CACHD1_uc001dbq.1_Missense_Mutation_p.D713G|CACHD1_uc010opa.1_Missense_Mutation_p.D202G	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1009	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						ACAGCTATTGACCCTGGCCTG	0.532													14	106					0	0	0	0	G	65142628	G	G	65142628	3	3	161	1	0	0	0	0	1	0	0	0	2549	275	10	5	2959	5	CACHD1	1	65142628	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08	1198127	65142628	184107993	4	29248											
FAM73A	374986	broad.mit.edu	37	chr1	78325024	78325024	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgttggagtgcctaggaGacagtgattttcttgccaaa	12	12	11	6	0	1	2	0	1	1	1	1	4	1	3	2	2	2	1	2	2	3	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:78325024G>C	uc001dhx.2	+	10	1173	c.1141G>C	c.(1141-1143)GAC>CAC	p.D381H	FAM73A_uc010ork.1_Missense_Mutation_p.D381H|FAM73A_uc010orl.1_Missense_Mutation_p.D343H|FAM73A_uc001dhy.1_3'UTR	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	381						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		GTGCCTAGGAGACAGTGATTT	0.383													8	55					0	0	0	0	C	78325024	C	C	78325024	3	2	161	1	0	0	0	0	1	0	0	0	5649	942	33	2	1179	2	FAM73A	1	78325024	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	13182396	78325024	170925597	5	29249											
DNASE2B	58511	broad.mit.edu	37	chr1	84864283	84864283	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcaagactgctaagaacAtcctttgctttgctcttcct	9	14	7	11	0	1	2	0	0	1	2	3	2	3	2	2	1	4	4	2	1	3	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:84864283A>T	uc001djt.1	+	1	69	c.36A>T	c.(34-36)ACA>ACT	p.T12T	UOX_uc009wcg.2_5'Flank	NM_021233	NP_067056	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta isoform 1 precursor	12					DNA metabolic process	lysosome	deoxyribonuclease II activity				0				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		TGCTAAGAACATCCTTTGCTT	0.463								Direct_reversal_of_damage					10	186					0	0	0	0	T	84864283	T	T	84864283	2	4	161	1	0	0	0	0	0	0	0	1	4687	204	8	5		5	DNASE2B	1	84864283	Silent	SNP	A	TCGA-CR-7395-01A-11D-2012-08	6539259	84864283	164386338	6	29250											
SYDE2	84144	broad.mit.edu	37	chr1	85648848	85648848	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agatggttccataattcccaAttcagtactatttgtagcag	12	14	7	8	0	1	1	1	0	0	1	3	1	3	1	2	1	2	4	2	1	5	8			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:85648848A>T	uc009wcm.2	-	3	1526	c.1477T>A	c.(1477-1479)TTG>ATG	p.L493M	SYDE2_uc001dku.3_Missense_Mutation_p.L493M	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	493					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		ATAATTCCCAATTCAGTACTA	0.328													12	81					0	0	0	0	T	85648848	T	T	85648848	3	4	161	1	0	0	0	0	1	0	0	0	15502	98	4	5	2127	5	SYDE2	1	85648848	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08	784565	85648848	163601773	7	29251											
DDAH1	23576	broad.mit.edu	37	chr1	85790448	85790448	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactttctggatactcttccGgggttcggtgcagcaagacg	7	11	12	11	3	2	1	0	0	2	1	4	2	3	2	1	4	3	3	1	4	2	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:85790448G>A	uc001dlb.2	-	5	877	c.716C>T	c.(715-717)CCG>CTG	p.P239L	DDAH1_uc001dlc.2_Missense_Mutation_p.P136L|uc001dla.1_Intron|DDAH1_uc010osb.1_Missense_Mutation_p.P139L|DDAH1_uc009wco.2_Missense_Mutation_p.P136L	NM_012137	NP_036269	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	239					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding				0				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	ATACTCTTCCGGGGTTCGGTG	0.473													11	78					0	0	0	0	A	85790448	A	A	85790448	3	1	161	1	0	0	0	0	1	0	0	0	4338	1116	39	1	149	1	DDAH1	1	85790448	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	141600	85790448	163460173	8	29252											
PKLR	5313	broad.mit.edu	37	chr1	155264372	155264372	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccacgtcgctggctttcCgcacaaaggaggcaaagacg	11	5	12	13	4	0	1	0	0	0	1	2	2	1	2	2	3	1	4	2	3	2	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:155264372C>T	uc001fkb.3	-	6	905	c.866G>A	c.(865-867)CGG>CAG	p.R289Q	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Missense_Mutation_p.R258Q	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	289					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity	p.R289L(1)		skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	GCTGGCTTTCCGCACAAAGGA	0.627													6	49					0	0	0	0	T	155264372	T	T	155264372	3	4	161	1	0	0	0	0	1	0	0	0	12031	652	23	1	882	1	PKLR	1	155264372	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	69473924	155264372	93986249	9	29253											
HMCN1	83872	broad.mit.edu	37	chr1	186026439	186026439	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaagaactcagtatctttGacttgtgaagcttctggaat	13	13	9	6	0	3	3	1	2	2	1	3	5	3	4	0	1	2	2	0	1	6	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:186026439G>A	uc001grq.1	+	46	7447	c.7218G>A	c.(7216-7218)TTG>TTA	p.L2406L		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2406	Ig-like C2-type 22.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAGTATCTTTGACTTGTGAAG	0.423													8	58					0	0	0	0	A	186026439	A	A	186026439	2	1	161	1	0	0	0	0	0	0	0	1	7259	1281	45	2		2	HMCN1	1	186026439	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	30762067	186026439	63224182	10	29254											
ZBTB41	360023	broad.mit.edu	37	chr1	197128556	197128556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tatcaaggcccagtaatgttCcaagataagattgttctcta	13	13	7	8	0	2	2	1	0	1	2	4	2	3	2	2	1	0	3	2	1	6	7			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:197128556C>T	uc001gtx.1	-	10	2732	c.2663G>A	c.(2662-2664)GGA>GAA	p.G888E	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	888					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						CAGTAATGTTCCAAGATAAGA	0.373													15	89					0	0	0	0	T	197128556	T	T	197128556	3	4	161	1	0	0	0	0	1	0	0	0	17610	855	30	2	70	2	ZBTB41	1	197128556	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	11102117	197128556	52122065	11	29255											
SOX13	9580	broad.mit.edu	37	chr1	204085730	204085730	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agctcctgacagcccactcgGagcagaagaacatggctgcc	11	5	11	14	1	0	3	0	1	0	2	2	4	1	4	3	2	5	3	3	2	2	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:204085730G>A	uc001ham.2	+	5	1109	c.514G>A	c.(514-516)GAG>AAG	p.E172K	SOX13_uc001hal.2_Missense_Mutation_p.E172K|SOX13_uc010pqp.1_Missense_Mutation_p.E172K|SOX13_uc010pqq.1_Missense_Mutation_p.E39K	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	172					anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			AGCCCACTCGGAGCAGAAGAA	0.597													7	77					0	0	0	0	A	204085730	A	A	204085730	3	1	161	1	0	0	0	0	1	0	0	0	15008	1175	41	2	528	2	SOX13	1	204085730	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	6957174	204085730	45164891	12	29256											
NFASC	23114	broad.mit.edu	37	chr1	204943329	204943329	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccgcctcggatgctgtcGccccggaaccagctcattcg	5	8	12	16	5	1	0	1	0	0	0	4	2	1	2	5	2	4	2	5	2	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:204943329G>A	uc001hbj.2	+	13	1630	c.1302G>A	c.(1300-1302)TCG>TCA	p.S434S	NFASC_uc001hbh.2_Silent_p.S434S|NFASC_uc010pqz.1_Silent_p.S428S|NFASC_uc010pra.1_Silent_p.S445S|NFASC_uc001hbi.2_Silent_p.S445S|NFASC_uc009xbg.1_Silent_p.S518S|NFASC_uc010prb.1_Silent_p.S445S|NFASC_uc010prc.1_5'UTR|NFASC_uc001hbk.1_Silent_p.S255S	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	434	Extracellular (Potential).|Ig-like C2-type 5.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGATGCTGTCGCCCCGGAACC	0.552													4	16					0	0	0	0	A	204943329	A	A	204943329	2	1	161	1	0	0	0	0	0	0	0	1	10413	1074	38	1		1	NFASC	1	204943329	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	857599	204943329	44307292	13	29257											
TTC13	79573	broad.mit.edu	37	chr1	231057232	231057232	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaaatattctaggtatctCatgttgatcacctgacccct	11	14	5	11	0	4	2	3	2	2	0	5	2	4	2	3	1	0	2	3	1	5	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:231057232C>G	uc001huf.3	-	16	1864	c.1833G>C	c.(1831-1833)ATG>ATC	p.M611I	TTC13_uc009xfi.2_Missense_Mutation_p.M558I|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.M558I|TTC13_uc009xfk.1_Missense_Mutation_p.M501I	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	611							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CTAGGTATCTCATGTTGATCA	0.264													3	29					0	0	0	0	G	231057232	G	G	231057232	3	3	161	1	0	0	0	0	1	0	0	0	16748	826	29	2	781	2	TTC13	1	231057232	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	26113903	231057232	18193389	14	29258											
OR1C1	26188	broad.mit.edu	37	chr1	247921358	247921358	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatatctatcatacgccatCacacacagaaggaggctgtc	14	8	7	12	1	3	1	2	0	1	1	4	2	3	2	1	2	1	1	1	2	4	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr1:247921358C>A	uc010pza.1	-	1	351	c.351G>T	c.(349-351)GTG>GTT	p.V117V		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CATACGCCATCACACACAGAA	0.488													6	53					5.9392e-07	1.19053e-06	1	0	A	247921358	A	A	247921358	2	1	161	1	0	0	0	0	0	0	0	1	11006	813	29	2		2	OR1C1	1	247921358	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	16864126	247921358	1329263	15	29259											
GREB1	9687	broad.mit.edu	37	chr2	11758602	11758602	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgggccgacgccccagcccGactgtagcctcaggaccggc	6	3	13	19	5	1	0	1	0	0	0	1	3	1	1	7	3	2	1	7	3	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:11758602G>A	uc002rbk.1	+	22	3901	c.3601G>A	c.(3601-3603)GAC>AAC	p.D1201N	GREB1_uc002rbp.1_Missense_Mutation_p.D199N	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1201	Ser-rich.					integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GCCCCAGCCCGACTGTAGCCT	0.692													8	18					0	0	0	0	A	11758602	A	A	11758602	3	1	161	1	0	0	0	0	1	0	0	0	6799	1058	37	1	3791	1	GREB1	2	11758602	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08		11758602	231440771	16	29260											
DNMT3A	1788	broad.mit.edu	37	chr2	25468900	25468900	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaacttaccctcaatgttcCggcacttctgccgcacctcg	8	10	6	17	3	2	0	1	0	1	0	4	0	3	0	4	1	3	3	4	1	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:25468900C>T	uc002rgc.2	-	12	1720	c.1463G>A	c.(1462-1464)CGG>CAG	p.R488Q	DNMT3A_uc002rgd.2_Missense_Mutation_p.R488Q|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.R299Q	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	488	ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding	p.R488fs?(1)		haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCAATGTTCCGGCACTTCTG	0.602			Mis|F|N|S		AML								10	67					0	0	0	0	T	25468900	T	T	25468900	3	4	161	1	0	0	0	0	1	0	0	0	4698	652	23	1	1323	1	DNMT3A	2	25468900	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	13710298	25468900	217730473	17	29261											
CAPN13	92291	broad.mit.edu	37	chr2	30961324	30961324	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggcatcaatgtccagcctCtgatccaaacaaggaaggaa	14	7	10	10	0	2	1	1	1	1	0	4	3	4	3	3	3	2	1	3	3	5	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:30961324C>T	uc002rnn.2	-	15	1713	c.1537_splice	c.e15-1	p.R513_splice	CAPN13_uc002rnm.2_Splice_Site	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13						proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TGTCCAGCCTCTGATCCAAAC	0.527													3	16					0	0	0	0	T	30961324	T	T	30961324	5	4	161	1	0	0	0	0	0	0	1	0	2638	927	32	2	501	2	CAPN13	2	30961324	Splice_Site	SNP	C	TCGA-CR-7395-01A-11D-2012-08	5492424	30961324	212238049	18	29262											
SFRS7	6432	broad.mit.edu	37	chr2	38976747	38976747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccacactcatagcatctatCatttggatcaaagggacgtc	12	10	8	11	1	4	0	3	0	1	0	5	2	4	2	1	2	1	1	1	2	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:38976747C>T	uc002rqz.2	-	3	548	c.310G>A	c.(310-312)GAT>AAT	p.D104N	SFRS7_uc002rra.2_RNA|SFRS7_uc010ynp.1_Missense_Mutation_p.D104N|GEMIN6_uc002rrb.2_5'Flank	NM_001031684	NP_001026854	Q16629	SRSF7_HUMAN	splicing factor, arginine/serine-rich 7	104	CCHC-type.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding|zinc ion binding				0		all_hematologic(82;0.248)				TAGCATCTATCATTTGGATCA	0.463													13	54					0	0	0	0	T	38976747	T	T	38976747	3	4	161	1	0	0	0	0	1	0	0	0	14247	826	29	2	430	2	SFRS7	2	38976747	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	8015423	38976747	204222626	19	29263											
FBXO11	80204	broad.mit.edu	37	chr2	48035487	48035487	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctatcatgtctaataaactCtacatcatgtccctgatggc	11	13	5	12	0	4	1	2	1	2	0	5	1	5	1	2	1	2	0	2	1	5	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:48035487C>G	uc010fbl.2	-	22	2497	c.2383G>C	c.(2383-2385)GAG>CAG	p.E795Q	FBXO11_uc002rwe.2_Missense_Mutation_p.E795Q|FBXO11_uc010fbk.2_Missense_Mutation_p.E303Q	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	879	UBR-type.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CTAATAAACTCTACATCATGT	0.353													5	56					0	0	0	0	G	48035487	G	G	48035487	3	3	161	1	0	0	0	0	1	0	0	0	5759	922	32	2	156	2	FBXO11	2	48035487	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	9058740	48035487	195163886	20	29264											
CCT4	10575	broad.mit.edu	37	chr2	62099641	62099641	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atagggcatcatgaatggagCgctcagcttcttcaatcacc	11	10	9	11	1	5	1	4	1	1	0	5	2	5	2	1	2	2	3	1	2	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:62099641C>T	uc002sbo.2	-	11	1357	c.1208G>A	c.(1207-1209)CGC>CAC	p.R403H	CCT4_uc010ypp.1_Missense_Mutation_p.R347H|CCT4_uc010ypq.1_Missense_Mutation_p.R253H|CCT4_uc010ypr.1_Missense_Mutation_p.R347H|CCT4_uc010yps.1_Missense_Mutation_p.R373H	NM_006430	NP_006421	P50991	TCPD_HUMAN	chaperonin containing TCP1, subunit 4 (delta)	403					'de novo' posttranslational protein folding	melanosome|microtubule organizing center|nucleus	ATP binding|unfolded protein binding			ovary(2)	2	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;6.5e-06)|Epithelial(17;0.0647)|all cancers(80;0.221)			ATGAATGGAGCGCTCAGCTTC	0.358													7	41					0	0	0	0	T	62099641	T	T	62099641	3	4	161	1	0	0	0	0	1	0	0	0	2970	768	27	1	427	1	CCT4	2	62099641	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	14064154	62099641	181099732	21	29265											
CIAO1	9391	broad.mit.edu	37	chr2	96933588	96933588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacagttgatgaagaggatGagtatgaatgtgtcagtgtt	12	12	13	4	0	1	5	1	4	0	1	1	6	1	6	1	1	0	3	1	1	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:96933588G>A	uc002svs.2	+	4	620	c.415G>A	c.(415-417)GAG>AAG	p.E139K	TMEM127_uc002svq.2_5'Flank|TMEM127_uc002svr.2_5'Flank	NM_004804	NP_004795	O76071	CIAO1_HUMAN	WD repeat domain 39	139	WD 3.				chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding				0						TGAAGAGGATGAGTATGAATG	0.537													5	64					0	0	0	0	A	96933588	A	A	96933588	3	1	161	1	0	0	0	0	1	0	0	0	3433	1291	45	2	429	2	CIAO1	2	96933588	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	34833947	96933588	146265785	22	29266											
RGPD3	653489	broad.mit.edu	37	chr2	107032306	107032306	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaggttttctgatctcacCttaatttgctccataaggac	9	14	7	11	0	2	1	1	1	2	0	4	2	3	2	3	2	1	2	3	2	2	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:107032306C>T	uc010ywi.1	-	21	5121	c.5064G>A	c.(5062-5064)AAG>AAA	p.K1688K		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1688					intracellular transport		binding			ovary(1)	1						CTGATCTCACCTTAATTTGCT	0.438													17	179					0	0	0	0	T	107032306	T	T	107032306	2	4	161	1	0	0	0	0	0	0	0	1	13352	695	24	4		4	RGPD3	2	107032306	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	10098718	107032306	136167067	23	29267											
ANAPC1	64682	broad.mit.edu	37	chr2	112608430	112608430	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggagtactgggccgaggcaTtgtgttggacatcgtcagag	8	10	16	7	2	1	1	1	0	0	1	2	4	1	3	1	4	1	3	1	4	1	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:112608430T>C	uc002thi.2	-	14	1820	c.1573A>G	c.(1573-1575)ATG>GTG	p.M525V		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	525					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						GGCCGAGGCATTGTGTTGGAC	0.438													8	33					0	0	0	0	C	112608430	C	C	112608430	3	2	161	1	0	0	0	0	1	0	0	0	598	1493	52	5	4401	5	ANAPC1	2	112608430	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	5576124	112608430	130590943	24	29268											
GLI2	2736	broad.mit.edu	37	chr2	121748215	121748215	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctccatgctcaccagcctCgccgaggagagcaagttcct	9	7	10	15	2	1	1	1	0	0	1	4	3	3	1	5	1	4	4	5	1	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:121748215C>T	uc010flp.2	+	13	4755	c.4725C>T	c.(4723-4725)CTC>CTT	p.L1575L	GLI2_uc002tmq.1_3'UTR|GLI2_uc002tmr.1_3'UTR|GLI2_uc002tmt.3_Silent_p.L1247L|GLI2_uc002tmu.3_Silent_p.L1230L	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1575					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				TCACCAGCCTCGCCGAGGAGA	0.647													14	104					0	0	0	0	T	121748215	T	T	121748215	2	4	161	1	0	0	0	0	0	0	0	1	6475	871	31	1		1	GLI2	2	121748215	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	9139785	121748215	121451158	25	29269											
YSK4	80122	broad.mit.edu	37	chr2	135744823	135744823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttacttgtcttggtctttGaatccaacttactcctatgg	7	18	6	10	0	3	1	0	1	3	0	5	1	5	1	2	2	3	0	2	2	5	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:135744823G>A	uc002tue.1	-	7	1650	c.1619C>T	c.(1618-1620)TCA>TTA	p.S540L	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.S427L|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.S268L|YSK4_uc002tui.3_Missense_Mutation_p.S557L	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	540							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTTGGTCTTTGAATCCAACTT	0.368													9	79					0	0	0	0	A	135744823	A	A	135744823	3	1	161	1	0	0	0	0	1	0	0	0	17563	1294	45	2	2383	2	YSK4	2	135744823	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	13996608	135744823	107454550	26	29270											
LRP2	4036	broad.mit.edu	37	chr2	170050337	170050337	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcaccgtcacagatccattCgcttgggatgcacctcccac	9	9	7	16	2	2	1	2	0	0	1	5	2	4	2	4	1	1	2	4	1	0	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:170050337C>T	uc002ues.2	-	47	8977	c.8764G>A	c.(8764-8766)GAA>AAA	p.E2922K		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2922	LDL-receptor class A 21.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CAGATCCATTCGCTTGGGATG	0.458													18	73					0	0	0	0	T	170050337	T	T	170050337	3	4	161	1	0	0	0	0	1	0	0	0	9006	893	31	1	5335	1	LRP2	2	170050337	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	34305514	170050337	73149036	27	29271											
PLEKHA3	65977	broad.mit.edu	37	chr2	179360322	179360322	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaatgccaagtttaaacctGagatgtttcaactgcaccat	13	11	6	11	0	1	1	1	1	0	1	1	2	1	1	4	0	4	3	4	0	5	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:179360322G>C	uc002umn.2	+	5	948	c.550G>C	c.(550-552)GAG>CAG	p.E184Q		NM_019091	NP_061964	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A	184						cytoplasm|membrane				ovary(1)|kidney(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			GTTTAAACCTGAGATGTTTCA	0.428													18	121					0	0	0	0	C	179360322	C	C	179360322	3	2	161	1	0	0	0	0	1	0	0	0	12112	1291	45	2	568	2	PLEKHA3	2	179360322	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	9309985	179360322	63839051	28	29272											
TTN	7273	broad.mit.edu	37	chr2	179481235	179481235	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttttccggctgacttctcGtttttcaacaacgtatccag	7	16	7	11	3	2	1	1	1	1	0	5	1	4	1	2	1	2	4	2	1	3	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:179481235G>A	uc010zfg.1	-	206	40803	c.40579C>T	c.(40579-40581)CGA>TGA	p.R13527*	TTN_uc010zfh.1_Nonsense_Mutation_p.R7222*|TTN_uc010zfi.1_Nonsense_Mutation_p.R7155*|TTN_uc010zfj.1_Nonsense_Mutation_p.R7030*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14454							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGACTTCTCGTTTTTCAACA	0.433													38	115					0	0	0	0	A	179481235	A	A	179481235	4	1	161	1	0	0	0	0	0	1	0	0	16803	1153	40	1	59834	1	TTN	2	179481235	Nonsense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	120913	179481235	63718138	29	29273											
CASP8	841	broad.mit.edu	37	chr2	202131442	202131443	+	Frame_Shift_Ins	INS	-	C	C																															ctggatttgctgattacctaINScctaaacactagaaaggagg																										TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:202131442_202131443insC	uc002uxr.1	+	3	442_443	c.233_234insC	c.(232-234)TACfs	p.Y78fs	CASP8_uc010ftc.1_Frame_Shift_Ins_p.Y78fs|CASP8_uc002uxo.1_Frame_Shift_Ins_p.Y78fs|CASP8_uc002uxp.1_Frame_Shift_Ins_p.Y78fs|CASP8_uc002uxq.1_Frame_Shift_Ins_p.Y78fs|CASP8_uc002uxs.1_Frame_Shift_Ins_p.Y78fs|CASP8_uc002uxt.1_Frame_Shift_Ins_p.Y137fs|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Frame_Shift_Ins_p.Y78fs|CASP8_uc002uxw.1_Frame_Shift_Ins_p.Y78fs|CASP8_uc002uxy.1_Frame_Shift_Ins_p.Y78fs|CASP8_uc002uxx.1_Frame_Shift_Ins_p.Y78fs|CASP8_uc010ftf.2_Frame_Shift_Ins_p.Y78fs	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	78	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CTGATTACCTACCTAAACACTA	0.475										HNSCC(4;0.00038)			---	---	---								C	202131443	C	C	202131442	7	5	161	1	0	1	1	0	0	0	0	0	2689	391	14	0	416	0	CASP8	2	202131442	Frame_Shift_Ins	INS	-	TCGA-CR-7395-01A-11D-2012-08	22650207	202131442	41067931	30	29274											
STRADB	55437	broad.mit.edu	37	chr2	202337702	202337702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggatttgacaacttgacttCtgtccatcttgcacggcata	10	13	8	10	1	2	2	0	2	2	0	3	3	3	3	1	2	2	2	1	2	2	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:202337702C>T	uc002uyd.3	+	5	583	c.218C>T	c.(217-219)TCT>TTT	p.S73F		NM_018571	NP_061041	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta	73	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			skin(2)|stomach(1)|lung(1)	4						AACTTGACTTCTGTCCATCTT	0.308													10	79					0	0	0	0	T	202337702	T	T	202337702	3	4	161	1	0	0	0	0	1	0	0	0	15391	913	32	2	232	2	STRADB	2	202337702	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	206260	202337702	40861671	31	29275											
PTH2R	5746	broad.mit.edu	37	chr2	209308254	209308254	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcaacttctgtggacaaaTcacaatatgtaagtgttttc	13	13	8	7	0	2	0	1	0	1	0	3	1	2	1	0	2	1	3	0	2	5	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:209308254T>C	uc002vdb.2	+	6	904	c.691T>C	c.(691-693)TCA>CCA	p.S231P	PTH2R_uc010zjb.1_Missense_Mutation_p.S242P	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	231	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TGTGGACAAATCACAATATGT	0.363													5	50					0	0	0	0	C	209308254	C	C	209308254	3	2	161	1	0	0	0	0	1	0	0	0	12823	1435	50	5	713	5	PTH2R	2	209308254	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	6970552	209308254	33891119	32	29276											
MARCH4	57574	broad.mit.edu	37	chr2	217124235	217124235	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtctcctcttccgaggaggGgatattggcctgggtggatg	5	11	17	8	1	2	0	0	0	2	0	4	4	3	3	3	7	0	0	3	7	1	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:217124235G>A	uc002vgb.2	-	4	2800	c.1033C>T	c.(1033-1035)CCC>TCC	p.P345S		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	345						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		TCCGAGGAGGGGATATTGGCC	0.632													5	29					0	0	0	0	A	217124235	A	A	217124235	3	1	161	1	0	0	0	0	1	0	0	0	9356	1232	43	4	203	4	MARCH4	2	217124235	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	7815981	217124235	26075138	33	29277											
BCS1L	617	broad.mit.edu	37	chr2	219527683	219527683	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggatggtgtggcttccaccGaggcccgcatcgtgttcatg	5	11	14	11	3	1	0	1	0	0	0	3	2	2	1	3	4	0	3	3	4	0	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr2:219527683G>A	uc002vio.2	+	7	1385	c.967G>A	c.(967-969)GAG>AAG	p.E323K	BCS1L_uc002vip.2_Missense_Mutation_p.E323K|BCS1L_uc002viq.2_Missense_Mutation_p.E323K|BCS1L_uc010fvu.2_Missense_Mutation_p.E323K|BCS1L_uc010fvv.2_Missense_Mutation_p.E323K|BCS1L_uc002vir.2_Missense_Mutation_p.E323K|BCS1L_uc002vis.2_Missense_Mutation_p.E323K	NM_004328	NP_004319	Q9Y276	BCS1_HUMAN	BCS1-like	323	Mitochondrial matrix (Potential).				mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCTTCCACCGAGGCCCGCAT	0.567													14	100					0	0	0	0	A	219527683	A	A	219527683	3	1	161	1	0	0	0	0	1	0	0	0	1391	1059	37	1	989	1	BCS1L	2	219527683	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	2403448	219527683	23671690	34	29278											
GOLGA4	2803	broad.mit.edu	37	chr3	37388711	37388711	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgtaccatacggatgtctCactctttggagaacctaccg	9	13	8	11	2	2	1	1	0	2	1	3	3	2	2	3	2	4	1	3	2	4	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:37388711C>T	uc003cgv.2	+	21	6804	c.6500C>T	c.(6499-6501)TCA>TTA	p.S2167L	GOLGA4_uc003cgw.2_Missense_Mutation_p.S2182L|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.S2048L	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	2167	Potential.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						ACGGATGTCTCACTCTTTGGA	0.343													6	61					0	0	0	0	T	37388711	T	T	37388711	3	4	161	1	0	0	0	0	1	0	0	0	6592	838	29	2	6652	2	GOLGA4	3	37388711	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08		37388711	160633719	35	29279											
XIRP1	165904	broad.mit.edu	37	chr3	39230363	39230363	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcgtctcaaagagcatccTggtaccctgcacatctccgc	8	8	8	17	3	2	1	1	0	2	1	5	1	3	1	4	1	3	3	4	1	2	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:39230363T>G	uc003cjk.1	-	2	795	c.574A>C	c.(574-576)AGG>CGG	p.R192R	XIRP1_uc003cji.2_Silent_p.R192R|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	192	Xin 4.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AAGAGCATCCTGGTACCCTGC	0.632													7	75					0	0	0	0	G	39230363	G	G	39230363	2	3	161	1	0	0	0	0	0	0	0	1	17497	1579	55	5		5	XIRP1	3	39230363	Silent	SNP	T	TCGA-CR-7395-01A-11D-2012-08	1841652	39230363	158792067	36	29280											
CX3CR1	1524	broad.mit.edu	37	chr3	39307506	39307506	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttctgctttgtgaacatGaactggggtgctgccaccaa	8	13	10	10	0	2	2	0	2	2	0	2	2	2	2	2	2	5	2	2	2	3	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:39307506G>A	uc003cjl.2	-	2	587	c.495C>T	c.(493-495)TTC>TTT	p.F165F		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	165	Helical; Name=4; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		TTGTGAACATGAACTGGGGTG	0.547													13	99					0	0	0	0	A	39307506	A	A	39307506	2	1	161	1	0	0	0	0	0	0	0	1	4092	1281	45	2		2	CX3CR1	3	39307506	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	77143	39307506	158714924	37	29281											
ZNF167	55888	broad.mit.edu	37	chr3	44609918	44609918	+	Silent	SNP	C	T	T																															gaaaatcaccatagcatggcCtccttgggtaatgattctgt																										TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:44609918C>T	uc010hin.2	+	5	1192	c.804C>T	c.(802-804)GCC>GCT	p.A268A	ZNF167_uc003cnh.2_RNA|ZNF167_uc003cni.2_Silent_p.A268A|ZNF167_uc010hio.2_Silent_p.A118A|ZNF167_uc003cnj.2_Silent_p.A268A|ZNF167_uc003cnk.2_Silent_p.A268A	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	268	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		ATAGCATGGCCTCCTTGGGTA	0.403													8	55					0	0	0	0	T	44609918	T	T	44609918	2	4	161	1	0	0	0	0	0	0	0	1	17808	668	24	4		4	ZNF167	3	44609918	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	5302412	44609918	153412512	38	29282	59	2									
ZNF167	55888	broad.mit.edu	37	chr3	44609921	44609921	+	Silent	SNP	C	T	T																															aatcaccatagcatggcctcCttgggtaatgattctgtttc																										TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:44609921C>T	uc010hin.2	+	5	1195	c.807C>T	c.(805-807)TCC>TCT	p.S269S	ZNF167_uc003cnh.2_RNA|ZNF167_uc003cni.2_Silent_p.S269S|ZNF167_uc010hio.2_Silent_p.S119S|ZNF167_uc003cnj.2_Silent_p.S269S|ZNF167_uc003cnk.2_Silent_p.S269S	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	269	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		GCATGGCCTCCTTGGGTAATG	0.398													8	54					0	0	0	0	T	44609921	T	T	44609921	2	4	161	1	0	0	0	0	0	0	0	1	17808	668	24	4		4	ZNF167	3	44609921	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	3	44609921	153412509	39	29283	59	2									
GRM2	2912	broad.mit.edu	37	chr3	51746802	51746802	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcctttgagggtgtggtgcGagccctgctgcagaagccca	6	8	16	11	1	0	2	0	1	0	1	0	3	0	2	3	3	5	2	3	3	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:51746802G>A	uc010hlv.2	+	3	1003	c.764G>A	c.(763-765)CGA>CAA	p.R255Q	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	255	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GGTGTGGTGCGAGCCCTGCTG	0.662													9	53					0	0	0	0	A	51746802	A	A	51746802	3	1	161	1	0	0	0	0	1	0	0	0	6836	1058	37	1	770	1	GRM2	3	51746802	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	7136881	51746802	146275628	40	29284											
OR5H14	403273	broad.mit.edu	37	chr3	97868522	97868522	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatatctctctctgaatgcaAgatacagttgttttcgtttg	9	17	8	7	1	2	2	0	1	2	1	5	3	2	2	0	0	2	4	0	0	4	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:97868522A>T	uc003dsg.1	+	1	293	c.293A>T	c.(292-294)AAG>ATG	p.K98M		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCTGAATGCAAGATACAGTTG	0.383													27	186					0	0	0	0	T	97868522	T	T	97868522	3	4	161	1	0	0	0	0	1	0	0	0	11214	72	3	5	295	5	OR5H14	3	97868522	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08	46121720	97868522	100153908	41	29285											
OR5H15	403274	broad.mit.edu	37	chr3	97887666	97887666	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tatctcatcaccatcatgggGaatcttggtctgattgctgt	8	15	9	9	0	5	1	3	1	3	0	6	2	5	2	1	3	1	1	1	3	2	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:97887666G>C	uc011bgu.1	+	1	123	c.123G>C	c.(121-123)GGG>GGC	p.G41G		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCATCATGGGGAATCTTGGTC	0.408													22	191					0	0	0	0	C	97887666	C	C	97887666	2	2	161	1	0	0	0	0	0	0	0	1	11215	1161	41	2		2	OR5H15	3	97887666	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	19144	97887666	100134764	42	29286											
PVRL3	25945	broad.mit.edu	37	chr3	110831075	110831075	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaggagaatatcagggaaGagtcttgtttaaaaattact	16	12	9	4	0	3	2	2	0	1	2	3	4	3	3	0	2	1	1	0	2	8	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:110831075G>A	uc003dxt.1	+	2	359	c.359G>A	c.(358-360)AGA>AAA	p.R120K	PVRL3_uc003dxu.1_Missense_Mutation_p.R97K	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	120	Extracellular (Potential).|Ig-like V-type.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						TATCAGGGAAGAGTCTTGTTT	0.373													7	50					0	0	0	0	A	110831075	A	A	110831075	3	1	161	1	0	0	0	0	1	0	0	0	12906	942	33	2	365	2	PVRL3	3	110831075	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	12943409	110831075	87191355	43	29287											
CEP63	80254	broad.mit.edu	37	chr3	134251719	134251719	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaagatcggtctgaaattGagaggttaactgcaaaaata	16	9	12	4	1	1	3	0	2	1	2	2	5	1	4	0	3	2	2	0	3	6	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:134251719G>A	uc003eqo.1	+	6	867	c.418G>A	c.(418-420)GAG>AAG	p.E140K	CEP63_uc003eql.1_Missense_Mutation_p.E140K|CEP63_uc003eqm.2_Missense_Mutation_p.E140K|CEP63_uc003eqn.1_Missense_Mutation_p.E140K	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	140	Potential.				cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						GTCTGAAATTGAGAGGTTAAC	0.363													9	22					0	0	0	0	A	134251719	A	A	134251719	3	1	161	1	0	0	0	0	1	0	0	0	3272	1291	45	2	432	2	CEP63	3	134251719	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	23420644	134251719	63770711	44	29288											
SOX14	8403	broad.mit.edu	37	chr3	137483941	137483941	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgggcgacacggacccgctCaaggcggctggcctgcccgt	5	5	15	16	5	1	0	1	0	0	0	1	2	1	1	3	5	1	2	3	5	1	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:137483941C>G	uc003erm.1	+	1	363	c.315C>G	c.(313-315)CTC>CTG	p.L105L		NM_004189	NP_004180	O95416	SOX14_HUMAN	SRY-box 14	105					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding				0						CGGACCCGCTCAAGGCGGCTG	0.687													7	39					0	0	0	0	G	137483941	G	G	137483941	2	3	161	1	0	0	0	0	0	0	0	1	15009	813	29	2		2	SOX14	3	137483941	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	3232222	137483941	60538489	45	29289											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	42					0	0	0	0	A	178936082	A	A	178936082	3	1	161	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	41452141	178936082	19086348	46	29290											
D4S234E	27065	broad.mit.edu	37	chr4	4419092	4419092	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catcacgcgctccgtatcgcCctggatgtcagttctgtcag	6	11	10	14	4	4	0	3	0	1	0	6	1	5	1	2	1	0	3	2	1	1	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr4:4419092C>T	uc011bvz.1	+	8	1769	c.488C>T	c.(487-489)CCC>CTC	p.P163L	D4S234E_uc011bwa.1_Missense_Mutation_p.P124L|D4S234E_uc003ghz.2_Missense_Mutation_p.P163L|D4S234E_uc003gia.2_Missense_Mutation_p.P163L|D4S234E_uc003gib.2_Missense_Mutation_p.P163L	NM_014392	NP_055207	P42857	NSG1_HUMAN	brain neuron cytoplasmic protein 1	163	Lumenal (Potential).				dopamine receptor signaling pathway	Golgi membrane|integral to membrane|nucleus	dopamine receptor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)		TCCGTATCGCCCTGGATGTCA	0.532													8	118					0	0	0	0	T	4419092	T	T	4419092	3	4	161	1	0	0	0	0	1	0	0	0	4231	623	22	4	502	4	D4S234E	4	4419092	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08		4419092	186735184	47	29291											
SLIT2	9353	broad.mit.edu	37	chr4	20611715	20611715	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctctctttgtccgtggatGgtgggaaccccaaaatcatc	8	12	10	11	1	3	0	1	0	2	0	6	2	4	2	3	3	1	0	3	3	3	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr4:20611715G>T	uc003gpr.1	+	34	3976	c.3772G>T	c.(3772-3774)GGT>TGT	p.G1258C	SLIT2_uc003gps.1_Missense_Mutation_p.G1250C	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1258	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						GTCCGTGGATGGTGGGAACCC	0.433													8	54					0.00307968	0.00606355	1	0	T	20611715	T	T	20611715	3	4	161	1	0	0	0	0	1	0	0	0	14804	1348	47	4	3906	4	SLIT2	4	20611715	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	16192623	20611715	170542561	48	29292											
C4orf19	55286	broad.mit.edu	37	chr4	37592483	37592483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgccatgcctgtggttgactCaggaaacaggcaggaggata	11	8	14	8	0	1	1	1	1	0	0	1	4	1	4	2	5	3	2	2	5	2	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr4:37592483C>T	uc003gsw.3	+	4	989	c.806C>T	c.(805-807)TCA>TTA	p.S269L	RELL1_uc003gsz.2_3'UTR|C4orf19_uc003gsy.3_Missense_Mutation_p.S269L	NM_001104629	NP_001098099	Q8IY42	CD019_HUMAN	hypothetical protein LOC55286	269											0						GTGGTTGACTCAGGAAACAGG	0.522													10	96					0	0	0	0	T	37592483	T	T	37592483	3	4	161	1	0	0	0	0	1	0	0	0	2263	838	29	2	812	2	C4orf19	4	37592483	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	16980768	37592483	153561793	49	29293											
FRYL	285527	broad.mit.edu	37	chr4	48542543	48542543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtacattttcaatcttctctCgactctctgatttatccaaa	10	17	3	11	1	4	1	1	1	3	0	8	2	5	1	1	0	1	1	1	0	4	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr4:48542543C>T	uc003gyh.1	-	46	6727	c.6122G>A	c.(6121-6123)CGA>CAA	p.R2041Q	FRYL_uc003gyg.1_Missense_Mutation_p.R737Q|FRYL_uc003gyi.1_Missense_Mutation_p.R929Q|FRYL_uc003gyj.1_Missense_Mutation_p.R336Q	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2041					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AATCTTCTCTCGACTCTCTGA	0.378													13	49					0	0	0	0	T	48542543	T	T	48542543	3	4	161	1	0	0	0	0	1	0	0	0	6098	884	31	1	2995	1	FRYL	4	48542543	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	10950060	48542543	142611733	50	29294											
GUCY1A3	2982	broad.mit.edu	37	chr4	156618130	156618130	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaggcagcaggaagctcAgagagctgcaaagcaaccgt	14	3	15	9	1	1	1	1	0	0	1	1	5	1	3	1	3	6	6	1	3	3	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr4:156618130A>G	uc003iov.2	+	4	647	c.111A>G	c.(109-111)TCA>TCG	p.S37S	GUCY1A3_uc003iou.2_Silent_p.S37S|GUCY1A3_uc010iqc.2_Silent_p.S37S|GUCY1A3_uc003iow.2_Silent_p.S37S|GUCY1A3_uc010iqd.2_Silent_p.S37S|GUCY1A3_uc003iox.2_Silent_p.S37S|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Silent_p.S37S|GUCY1A3_uc010iqe.2_5'UTR|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Silent_p.S37S	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	37					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CAGGAAGCTCAGAGAGCTGCA	0.493													6	51					0	0	0	0	G	156618130	G	G	156618130	2	3	161	1	0	0	0	0	0	0	0	1	6933	175	7	5		5	GUCY1A3	4	156618130	Silent	SNP	A	TCGA-CR-7395-01A-11D-2012-08	108075587	156618130	34536146	51	29295											
FAT1	2195	broad.mit.edu	37	chr4	187628809	187628809	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggctggttttcctttacctGaataccagtcggaagagtgc	9	12	11	9	1	0	2	0	1	0	1	2	3	1	3	3	3	3	2	3	3	4	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr4:187628809G>A	uc003izf.2	-	2	2361	c.2173C>T	c.(2173-2175)CAG>TAG	p.Q725*	FAT1_uc010iso.1_Nonsense_Mutation_p.Q725*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	725	Extracellular (Potential).|Cadherin 6.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TCCTTTACCTGAATACCAGTC	0.443										HNSCC(5;0.00058)			9	45					0	0	0	0	A	187628809	A	A	187628809	4	1	161	1	0	0	0	0	0	1	0	0	5721	1299	45	2	11697	2	FAT1	4	187628809	Nonsense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	31010679	187628809	3525467	52	29296											
AGXT2	64902	broad.mit.edu	37	chr5	35037140	35037140	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgtatgccacaggcggccGagctgcttttgtgccactgc	5	11	12	13	2	0	0	0	0	0	0	0	1	0	0	3	2	5	3	3	2	1	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:35037140G>A	uc003jjf.2	-	4	472	c.393C>T	c.(391-393)CTC>CTT	p.L131L	AGXT2_uc011com.1_Silent_p.L131L|AGXT2_uc011con.1_Silent_p.L39L	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	131					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	ACAGGCGGCCGAGCTGCTTTT	0.532													10	59					0	0	0	0	A	35037140	A	A	35037140	2	1	161	1	0	0	0	0	0	0	0	1	405	1045	37	1		1	AGXT2	5	35037140	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08		35037140	145878120	53	29297											
NUP155	9631	broad.mit.edu	37	chr5	37327823	37327823	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caactcatatttgtggcctgAgttgctgggtttcccagagc	7	13	11	10	0	1	2	1	1	0	1	2	2	2	2	2	2	3	3	2	2	2	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:37327823A>C	uc003jku.1	-	18	2050	c.1932T>G	c.(1930-1932)ACT>ACG	p.T644T	NUP155_uc003jkt.1_Silent_p.T585T|NUP155_uc010iuz.1_Silent_p.T644T	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	644	Pro-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGTGGCCTGAGTTGCTGGGT	0.413													4	36					0	0	0	0	C	37327823	C	C	37327823	2	2	161	1	0	0	0	0	0	0	0	1	10810	291	11	5		5	NUP155	5	37327823	Silent	SNP	A	TCGA-CR-7395-01A-11D-2012-08	2290683	37327823	143587437	54	29298											
WDR70	55100	broad.mit.edu	37	chr5	37605304	37605304	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcatagcagctgcctgccaGaatggaagcatacagatctg	12	8	10	11	0	2	2	1	0	1	2	2	3	2	3	2	1	6	3	2	1	4	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:37605304G>A	uc003jkv.2	+	10	1114	c.1056G>A	c.(1054-1056)CAG>CAA	p.Q352Q	WDR70_uc010iva.1_Silent_p.Q352Q	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	352	WD 4.									ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTGCCTGCCAGAATGGAAGCA	0.413													7	34					0	0	0	0	A	37605304	A	A	37605304	2	1	161	1	0	0	0	0	0	0	0	1	17389	933	33	2		2	WDR70	5	37605304	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	277481	37605304	143309956	55	29299											
SERINC5	256987	broad.mit.edu	37	chr5	79473837	79473837	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatcccaccagcttctcaCaggtgtcaccagctttaatg	11	11	6	13	0	2	0	2	0	1	0	4	0	3	0	3	1	2	2	3	1	3	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:79473837C>T	uc003kgj.2	-	3	374	c.245G>A	c.(244-246)TGT>TAT	p.C82Y	SERINC5_uc003kgk.2_Missense_Mutation_p.C82Y|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.C82Y|SERINC5_uc011ctj.1_Missense_Mutation_p.C82Y	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	82	Cytoplasmic (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		CAGCTTCTCACAGGTGTCACC	0.398													4	11					0	0	0	0	T	79473837	T	T	79473837	3	4	161	1	0	0	0	0	1	0	0	0	14148	478	17	4	1218	4	SERINC5	5	79473837	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	41868533	79473837	101441423	56	29300											
ERAP2	64167	broad.mit.edu	37	chr5	96239261	96239261	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatgatgtgtttcagctagTtgggtaaggcaacatttcct	9	15	10	7	0	2	1	2	1	0	0	3	1	3	1	1	2	2	5	1	2	3	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:96239261T>C	uc003kmq.2	+	13	2719	c.2009T>C	c.(2008-2010)GTT>GCT	p.V670A	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.V670A|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.V619A|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	670	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		TTTCAGCTAGTTGGGTAAGGC	0.403													4	38					0	0	0	0	C	96239261	C	C	96239261	3	2	161	1	0	0	0	0	1	0	0	0	5228	1725	60	5	2055	5	ERAP2	5	96239261	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	16765424	96239261	84675999	57	29301											
MEGF10	84466	broad.mit.edu	37	chr5	126784914	126784914	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcggctacctcaacgagctcGgtgagttctcccaacgcacg	8	7	11	15	5	2	1	1	1	1	0	4	2	2	1	2	2	4	4	2	2	3	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:126784914G>A	uc003kuh.3	+	23	3342	c.2980G>A	c.(2980-2982)GGT>AGT	p.G994S	MEGF10_uc003kui.3_Missense_Mutation_p.G994S	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	994	Cytoplasmic (Potential).|Necessary for formation of large intracellular vacuoles.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CAACGAGCTCGGTGAGTTCTC	0.532													4	77					0	0	0	0	A	126784914	A	A	126784914	3	1	161	1	0	0	0	0	1	0	0	0	9513	1130	39	1	3062	1	MEGF10	5	126784914	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	30545653	126784914	54130346	58	29302											
PCDHA1	56147	broad.mit.edu	37	chr5	140166069	140166069	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctggtgcctcgcctgttccGggtggcgtccaaaacacaca	7	8	12	14	3	0	0	0	0	0	0	3	0	2	0	4	3	2	2	4	3	2	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:140166069G>A	uc003lhb.2	+	1	194	c.194G>A	c.(193-195)CGG>CAG	p.R65Q	PCDHA1_uc003lha.2_Missense_Mutation_p.R65Q|PCDHA1_uc003lgz.2_Missense_Mutation_p.R65Q	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	65	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCTGTTCCGGGTGGCGTCC	0.587													17	105					0	0	0	0	A	140166069	A	A	140166069	3	1	161	1	0	0	0	0	1	0	0	0	11573	1116	39	1	196	1	PCDHA1	5	140166069	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	13381155	140166069	40749191	59	29303											
PCDHGB3	56102	broad.mit.edu	37	chr5	140751849	140751849	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggtgaggtgcgcacggcgCgtaccttgggcgacagggag	6	5	20	10	6	0	1	0	1	0	0	0	3	0	2	1	5	2	2	1	5	1	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:140751849C>T	uc003ljw.1	+	1	1888	c.1888C>T	c.(1888-1890)CGT>TGT	p.R630C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.R630C|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	630	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCACGGCGCGTACCTTGGG	0.662													11	98					0	0	0	0	T	140751849	T	T	140751849	3	4	161	1	0	0	0	0	1	0	0	0	11618	768	27	1	1890	1	PCDHGB3	5	140751849	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	585780	140751849	40163411	60	29304											
GPR151	134391	broad.mit.edu	37	chr5	145895392	145895392	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttggagtacgccgtagcTcggataggtgcagaaaacag	11	9	13	8	3	0	1	0	0	0	1	1	3	0	3	1	3	4	4	1	3	5	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:145895392T>C	uc003lod.1	-	1	285	c.285A>G	c.(283-285)CGA>CGG	p.R95R		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	95	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACGCCGTAGCTCGGATAGGTG	0.502													11	68					0	0	0	0	C	145895392	C	C	145895392	2	2	161	1	0	0	0	0	0	0	0	1	6695	1538	54	5		5	GPR151	5	145895392	Silent	SNP	T	TCGA-CR-7395-01A-11D-2012-08	5143543	145895392	35019868	61	29305											
NSD1	64324	broad.mit.edu	37	chr5	176715829	176715829	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcttatgcaggcactgaacTtaccttcaactacaacctag	12	11	5	13	0	2	1	1	1	1	0	2	1	2	1	2	1	6	2	2	1	7	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:176715829T>G	uc003mfr.3	+	21	6299	c.6161T>G	c.(6160-6162)CTT>CGT	p.L2054R	NSD1_uc003mft.3_Missense_Mutation_p.L1785R|NSD1_uc011dfx.1_Missense_Mutation_p.L1702R	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2054	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GGCACTGAACTTACCTTCAAC	0.393			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			4	86					0	0	0	0	G	176715829	G	G	176715829	3	3	161	1	0	0	0	0	1	0	0	0	10723	1609	56	5	6239	5	NSD1	5	176715829	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	30820437	176715829	4199431	62	29306											
MAPK9	5601	broad.mit.edu	37	chr5	179676105	179676105	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggatcttcagggtgcagtCtgatttcacaacaatgttgc	11	12	10	8	0	4	1	2	1	2	0	4	2	4	2	0	2	3	2	0	2	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr5:179676105C>G	uc003mls.3	-	6	755	c.484G>C	c.(484-486)GAC>CAC	p.D162H	MAPK9_uc003mlt.3_Missense_Mutation_p.D162H|MAPK9_uc010jlc.2_Missense_Mutation_p.D162H|MAPK9_uc003mlv.3_Missense_Mutation_p.D162H|MAPK9_uc011dgx.1_Missense_Mutation_p.D162H	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	162	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGGTGCAGTCTGATTTCACA	0.463													12	96					0	0	0	0	G	179676105	G	G	179676105	3	3	161	1	0	0	0	0	1	0	0	0	9340	913	32	2	940	2	MAPK9	5	179676105	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	2960276	179676105	1239155	63	29307											
CAP2	10486	broad.mit.edu	37	chr6	17551730	17551730	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaacaatttccattaataaGacagaaggttgccacatata	17	10	5	9	0	0	2	0	0	0	2	1	2	1	2	3	1	2	1	3	1	7	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:17551730G>A	uc003ncb.2	+	12	1488	c.1245G>A	c.(1243-1245)AAG>AAA	p.K415K	CAP2_uc010jpk.1_RNA|CAP2_uc011dja.1_Silent_p.K389K|CAP2_uc011djb.1_Silent_p.K351K|CAP2_uc011djc.1_Silent_p.K303K|CAP2_uc011djd.1_Silent_p.K155K	NM_006366	NP_006357	P40123	CAP2_HUMAN	adenylyl cyclase-associated protein 2	415	C-CAP/cofactor C-like.				activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			ovary(1)	1	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			CCATTAATAAGACAGAAGGTT	0.408													10	66					0	0	0	0	A	17551730	A	A	17551730	2	1	161	1	0	0	0	0	0	0	0	1	2632	933	33	2		2	CAP2	6	17551730	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08		17551730	153563337	64	29308											
NHLRC1	378884	broad.mit.edu	37	chr6	18121917	18121917	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctcagcccaaaggtatcCacttggccgacaagctgcat	11	7	10	13	1	1	0	1	0	0	0	2	1	2	0	3	3	3	4	3	3	3	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:18121917C>T	uc003ncl.1	-	1	935	c.921G>A	c.(919-921)GTG>GTA	p.V307V		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	307	NHL 5.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			CAAAGGTATCCACTTGGCCGA	0.547													16	61					0	0	0	0	T	18121917	T	T	18121917	2	4	161	1	0	0	0	0	0	0	0	1	10459	581	21	4		4	NHLRC1	6	18121917	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	570187	18121917	152993150	65	29309											
NHLRC1	378884	broad.mit.edu	37	chr6	18122747	18122747	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccggtggccaaacttctCaaagcacaccttgcactcga	10	8	8	15	2	1	0	1	0	1	0	3	1	1	0	3	2	4	2	3	2	2	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:18122747C>G	uc003ncl.1	-	1	105	c.91G>C	c.(91-93)GAG>CAG	p.E31Q		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	31	RING-type.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			CCAAACTTCTCAAAGCACACC	0.706													7	35					0	0	0	0	G	18122747	G	G	18122747	3	3	161	1	0	0	0	0	1	0	0	0	10459	835	29	2	1100	2	NHLRC1	6	18122747	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	830	18122747	152992320	66	29310											
KAAG1	353219	broad.mit.edu	37	chr6	24357946	24357946	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttcacgacgggctgagaCaggtggctggacctggcgct	6	8	15	12	3	2	1	1	1	1	1	2	4	2	2	1	5	0	3	1	5	0	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:24357946C>T	uc003ndz.1	+	1	816	c.79C>T	c.(79-81)CAG>TAG	p.Q27*	DCDC2_uc003ndx.2_Silent_p.L11L|DCDC2_uc003ndy.2_Silent_p.L11L	NM_181337	NP_851854	Q9UBP8	KAAG1_HUMAN	kidney associated antigen 1	27					immune response						0						CGGGCTGAGACAGGTGGCTGG	0.687													11	64					0	0	0	0	T	24357946	T	T	24357946	4	4	161	1	0	0	0	0	0	1	0	0	8012	479	17	4	81	4	KAAG1	6	24357946	Nonsense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	6235199	24357946	146757121	67	29311											
ZNF323	64288	broad.mit.edu	37	chr6	28294045	28294045	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatagggtttctcaccagtGtggactcggagatgctggaa	9	11	14	7	1	1	2	1	1	1	1	3	5	1	4	1	4	1	2	1	4	2	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:28294045G>C	uc003nla.2	-	4	1519	c.1119C>G	c.(1117-1119)CAC>CAG	p.H373Q	ZNF323_uc003nld.2_Missense_Mutation_p.H373Q|ZNF323_uc010jra.2_Missense_Mutation_p.H373Q|ZNF323_uc003nlb.2_Missense_Mutation_p.H214Q|ZNF323_uc010jrb.2_Missense_Mutation_p.H214Q|ZNF323_uc003nlc.2_Missense_Mutation_p.H373Q	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	373	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCTCACCAGTGTGGACTCGGA	0.473													25	232					0	0	0	0	C	28294045	C	C	28294045	3	2	161	1	0	0	0	0	1	0	0	0	17910	1368	48	4	105	4	ZNF323	6	28294045	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	3936099	28294045	142821022	68	29312											
HLA-A	3105	broad.mit.edu	37	chr6	29910405	29910405	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacccagacctgggcgggTgagtgcggggtcgggaggga	6	5	21	9	3	0	3	0	2	0	1	1	5	0	5	2	6	1	0	2	6	0	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:29910405T>G	uc003nol.2	+	1	73	c.73_splice	c.e1+2	p.G25_splice	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_Splice_Site|HLA-A_uc003nok.2_Splice_Site|HLA-A_uc003non.2_Splice_Site_p.G25_splice|HLA-A_uc003noo.2_Splice_Site_p.G25_splice|HLA-A_uc010jrr.2_Splice_Site_p.G25_splice|HLA-A_uc003nom.2_Splice_Site|HLA-A_uc010klp.2_5'Flank|HLA-A_uc011dmc.1_5'Flank|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A						antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CCTGGGCGGGTGAGTGCGGGG	0.736									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			11	45					0	0	0	0	G	29910405	G	G	29910405	5	3	161	1	0	0	0	0	0	0	1	0	7234	1710	59	5	77	5	HLA-A	6	29910405	Splice_Site	SNP	T	TCGA-CR-7395-01A-11D-2012-08	1616360	29910405	141204662	69	29313											
HLA-B	3106	broad.mit.edu	37	chr6	31323342	31323343	+	Frame_Shift_Ins	INS	-	G	G																															ctcatggtcagagatggggtINSggtgggtcacgtgtgtcttt																								rs80060802		TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:31323342_31323343insG	uc003nth.2	-	4	700_701	c.646_647insC	c.(646-648)CACfs	p.H216fs	HLA-C_uc003ntb.2_RNA|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_RNA|HLA-B_uc011dnk.1_RNA|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Frame_Shift_Ins_p.H95fs|HLA-B_uc003nti.1_RNA|HLA-B_uc010jsn.1_RNA|HLA-B_uc010jso.2_3'UTR	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	216	Alpha-3.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						AGAGATGGGGTGGTGGGTCACG	0.584									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				---	---	---								G	31323343	G	G	31323342	7	5	161	1	0	1	1	0	0	0	0	0	7235	1696	59	0	457	0	HLA-B	6	31323342	Frame_Shift_Ins	INS	-	TCGA-CR-7395-01A-11D-2012-08	1412937	31323342	139791725	70	29314											
AGPAT1	10554	broad.mit.edu	37	chr6	32138238	32138238	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctgggcgacctcagacatGacactgatggcatcccccgt	8	8	11	14	2	2	3	1	2	1	1	3	4	3	3	3	2	0	1	3	2	0	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:32138238G>A	uc003oae.2	-	4	792	c.474C>T	c.(472-474)GTC>GTT	p.V158V	PPT2_uc003nzy.1_RNA|AGPAT1_uc011dpj.1_RNA|AGPAT1_uc011dpk.1_Silent_p.V122V|AGPAT1_uc003oaf.2_Silent_p.V158V|AGPAT1_uc003oag.2_Intron|AGPAT1_uc003oah.2_Silent_p.V158V|AGPAT1_uc003oai.1_Silent_p.V158V|AGPAT1_uc011dpl.1_Silent_p.V46V	NM_006411	NP_006402	Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	158					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)	1						CCTCAGACATGACACTGATGG	0.592													8	75					0	0	0	0	A	32138238	A	A	32138238	2	1	161	1	0	0	0	0	0	0	0	1	386	1277	45	2		2	AGPAT1	6	32138238	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	814896	32138238	138976829	71	29315											
C6orf125	84300	broad.mit.edu	37	chr6	33679329	33679329	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcctccccgccggtcacctgGgtattctctccctcccgaaa	5	9	8	19	3	2	0	1	0	1	0	6	1	5	0	7	2	0	1	7	2	2	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:33679329G>A	uc003ofa.1	-	1	176	c.135C>T	c.(133-135)ACC>ACT	p.T45T	C6orf125_uc010jve.1_RNA	NM_032340	NP_115716	Q9BRT2	CF125_HUMAN	hypothetical protein LOC84300	45											0						CGGTCACCTGGGTATTCTCTC	0.687													7	43					0	0	0	0	A	33679329	A	A	33679329	2	1	161	1	0	0	0	0	0	0	0	1	2335	1219	43	4		4	C6orf125	6	33679329	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	1541091	33679329	137435738	72	29316											
SUPT3H	8464	broad.mit.edu	37	chr6	44988309	44988309	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgcgcatcaaaaacagaaGatcttcaggagtgattaccc	14	10	8	9	1	3	3	2	1	1	2	3	4	3	4	1	1	3	1	1	1	4	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:44988309G>A	uc003oxo.2	-	6	598	c.280C>T	c.(280-282)CTT>TTT	p.L94F	SUPT3H_uc003oxn.1_Missense_Mutation_p.L83F|SUPT3H_uc011dvv.1_5'UTR|SUPT3H_uc003oxp.2_Missense_Mutation_p.L83F|SUPT3H_uc011dvw.1_5'UTR	NM_181356	NP_852001	O75486	SUPT3_HUMAN	suppressor of Ty 3 homolog isoform 2	165					histone deubiquitination|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	STAGA complex|transcription factor TFTC complex	DNA binding|transcription coactivator activity			ovary(2)|breast(1)	3						AAAAACAGAAGATCTTCAGGA	0.328													4	32					0	0	0	0	A	44988309	A	A	44988309	3	1	161	1	0	0	0	0	1	0	0	0	15463	942	33	2	738	2	SUPT3H	6	44988309	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	11308980	44988309	126126758	73	29317											
DST	667	broad.mit.edu	37	chr6	56494093	56494094	+	Frame_Shift_Del	DEL	TG	-	-																															tttgccacctttcaactaatTgatctgctttttctttgtgc																										TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:56494093_56494094delTG	uc003pdf.2	-	31	4358_4359	c.4330_4331delCA	c.(4330-4332)CAAfs	p.Q1444fs	DST_uc003pcz.3_Frame_Shift_Del_p.Q1266fs|DST_uc011dxj.1_Frame_Shift_Del_p.Q1295fs|DST_uc011dxk.1_Frame_Shift_Del_p.Q1306fs|DST_uc003pcy.3_Frame_Shift_Del_p.Q940fs|DST_uc003pdb.2_Frame_Shift_Del_p.Q940fs|DST_uc003pdc.3_Frame_Shift_Del_p.Q940fs|DST_uc003pdd.3_Frame_Shift_Del_p.Q940fs	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1266					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTCAACTAATTGATCTGCTTTT	0.356													---	---	---								-	56494094	-	-	56494093	7	5	161	1	0	1	0	1	0	0	0	0	4805	1812	63	0	17604	0	DST	6	56494093	Frame_Shift_Del	DEL	TG	TCGA-CR-7395-01A-11D-2012-08	11505784	56494093	114620974	74	29318											
PHIP	55023	broad.mit.edu	37	chr6	79668289	79668289	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtattatgctctatatatcGaacttcccacattagggaag	12	14	7	8	1	1	0	0	0	1	0	3	2	2	1	1	1	2	2	1	1	8	7			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:79668289G>A	uc003pir.2	-	32	3911	c.3685C>T	c.(3685-3687)CGA>TGA	p.R1229*	PHIP_uc003piq.2_Nonsense_Mutation_p.R253*|PHIP_uc011dyp.1_Nonsense_Mutation_p.R1228*|PHIP_uc003pio.3_Nonsense_Mutation_p.R115*	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1229	Bromo 1.				insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TCTATATATCGAACTTCCCAC	0.313													6	42					0	0	0	0	A	79668289	A	A	79668289	4	1	161	1	0	0	0	0	0	1	0	0	11897	1066	37	1	1816	1	PHIP	6	79668289	Nonsense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	23174196	79668289	91446778	75	29319											
DOPEY1	23033	broad.mit.edu	37	chr6	83841951	83841951	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggacacctcagcatcaccaGaagagtgtggaactatttta	13	9	10	9	0	2	2	2	0	0	2	2	4	2	4	2	2	2	1	2	2	4	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:83841951G>A	uc003pjs.1	+	18	2933	c.2673G>A	c.(2671-2673)CAG>CAA	p.Q891Q	DOPEY1_uc011dyy.1_Silent_p.Q882Q|DOPEY1_uc010kbl.1_Silent_p.Q882Q	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	891					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AGCATCACCAGAAGAGTGTGG	0.373													5	82					0	0	0	0	A	83841951	A	A	83841951	2	1	161	1	0	0	0	0	0	0	0	1	4729	933	33	2		2	DOPEY1	6	83841951	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	4173662	83841951	87273116	76	29320											
HTR1E	3354	broad.mit.edu	37	chr6	87725377	87725377	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgacctgctgcacctgcTccatcctccacctctgtgtc	6	11	6	18	0	1	1	0	1	1	0	5	1	4	1	6	0	3	3	6	0	0	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:87725377T>C	uc003pli.2	+	2	1028	c.325T>C	c.(325-327)TCC>CCC	p.S109P		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	109	Helical; Name=3; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CTGCACCTGCTCCATCCTCCA	0.562													10	89					0	0	0	0	C	87725377	C	C	87725377	3	2	161	1	0	0	0	0	1	0	0	0	7478	1551	54	5	327	5	HTR1E	6	87725377	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	3883426	87725377	83389690	77	29321											
ZNF292	23036	broad.mit.edu	37	chr6	87971506	87971506	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tataggtaaagccacaggcaGaggtcagtactgataattaa	16	9	10	6	0	1	2	1	1	0	1	1	2	1	2	1	3	2	3	1	3	7	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:87971506G>A	uc003plm.3	+	8	8200	c.8159G>A	c.(8158-8160)AGA>AAA	p.R2720K		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2720					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GCCACAGGCAGAGGTCAGTAC	0.318													4	33					0	0	0	0	A	87971506	A	A	87971506	3	1	161	1	0	0	0	0	1	0	0	0	17893	942	33	2	8189	2	ZNF292	6	87971506	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	246129	87971506	83143561	78	29322											
SOBP	55084	broad.mit.edu	37	chr6	107956508	107956508	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgcctatgctctgcggatGctgcccaagaccggctgcgt	6	9	12	14	3	1	1	0	0	1	1	1	2	1	2	3	2	6	3	3	2	2	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:107956508G>T	uc003prx.2	+	6	2964	c.2460G>T	c.(2458-2460)ATG>ATT	p.M820I		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	820							metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		CTCTGCGGATGCTGCCCAAGA	0.647													18	122					9.16793e-09	1.86302e-08	1	0	T	107956508	T	T	107956508	3	4	161	1	0	0	0	0	1	0	0	0	14976	1319	46	4	2482	4	SOBP	6	107956508	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	19985002	107956508	63158559	79	29323											
SYNJ2	8871	broad.mit.edu	37	chr6	158516741	158516741	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggcccctcctgtcgtgaCagcccctcgagtccctcctg	4	9	10	18	2	0	2	0	2	0	0	5	3	3	2	7	1	1	0	7	1	0	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr6:158516741C>T	uc003qqx.1	+	27	3911	c.3836C>T	c.(3835-3837)ACA>ATA	p.T1279I	SYNJ2_uc003qqy.1_Missense_Mutation_p.T992I|SYNJ2_uc003qqz.1_Missense_Mutation_p.T896I|SYNJ2_uc003qra.1_Missense_Mutation_p.T622I|SYNJ2_uc010kjp.1_Missense_Mutation_p.T162I	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1279	Catalytic (By similarity).|Pro-rich.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CCTGTCGTGACAGCCCCTCGA	0.567													10	65					0	0	0	0	T	158516741	T	T	158516741	3	4	161	1	0	0	0	0	1	0	0	0	15519	478	17	4	3942	4	SYNJ2	6	158516741	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	50560233	158516741	12598326	80	29324											
STAG3	10734	broad.mit.edu	37	chr7	99794806	99794806	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcctgagatccgtgctatCtgcattgaggaaattgggtg	8	13	12	8	1	1	2	0	2	1	1	3	4	3	3	2	2	2	2	2	2	2	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr7:99794806C>T	uc003utx.1	+	10	1124	c.969C>T	c.(967-969)ATC>ATT	p.I323I	STAG3_uc010lgs.1_Silent_p.I111I|STAG3_uc011kjk.1_Silent_p.I265I	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	323	SCD.				chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCCGTGCTATCTGCATTGAGG	0.453													31	244					0	0	0	0	T	99794806	T	T	99794806	2	4	161	1	0	0	0	0	0	0	0	1	15310	903	32	2		2	STAG3	7	99794806	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08		99794806	59343857	81	29325											
LRRN3	54674	broad.mit.edu	37	chr7	110763864	110763864	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatgctgaacagcaatgctCtcagtgccctgtaccatggt	9	11	9	12	0	2	1	2	1	1	0	3	1	2	1	2	1	6	4	2	1	3	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr7:110763864C>T	uc003vft.3	+	4	2082	c.1036C>T	c.(1036-1038)CTC>TTC	p.L346F	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.L346F|LRRN3_uc003vfs.3_Missense_Mutation_p.L346F	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	346	Extracellular (Potential).|LRR 12.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		CAGCAATGCTCTCAGTGCCCT	0.453													16	71					0	0	0	0	T	110763864	T	T	110763864	3	4	161	1	0	0	0	0	1	0	0	0	9086	913	32	2	1038	2	LRRN3	7	110763864	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	10969058	110763864	48374799	82	29326											
FEZF1	389549	broad.mit.edu	37	chr7	121943818	121943818	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcatgtaatgctgcagcTgagcctgggacaggtctttg	7	13	12	9	0	2	1	1	1	1	0	2	2	2	2	1	2	4	4	1	2	1	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr7:121943818T>G	uc003vkd.2	-	1	748	c.674A>C	c.(673-675)CAG>CCG	p.Q225P	FEZF1_uc003vkc.2_Missense_Mutation_p.Q175P|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	225					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Q225H(1)		ovary(2)|breast(1)	3						ATGCTGCAGCTGAGCCTGGGA	0.507													3	108					0	0	0	0	G	121943818	G	G	121943818	3	3	161	1	0	0	0	0	1	0	0	0	5857	1580	55	5	769	5	FEZF1	7	121943818	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	11179954	121943818	37194845	83	29327											
PLXNA4	91584	broad.mit.edu	37	chr7	132192787	132192787	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcttaatcatcgaggccacGaactcatcatggaagacgta	14	9	8	10	3	4	1	3	0	1	1	5	4	4	2	1	2	1	1	1	2	4	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr7:132192787G>A	uc003vra.3	-	2	895	c.666C>T	c.(664-666)TTC>TTT	p.F222F	PLXNA4_uc003vrc.2_Silent_p.F222F|PLXNA4_uc003vrb.2_Silent_p.F222F	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	222	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TCGAGGCCACGAACTCATCAT	0.488													7	102					0	0	0	0	A	132192787	A	A	132192787	2	1	161	1	0	0	0	0	0	0	0	1	12177	1049	37	1		1	PLXNA4	7	132192787	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	10248969	132192787	26945876	84	29328											
KIAA1549	57670	broad.mit.edu	37	chr7	138602131	138602131	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taggaggtagtttcaatgaaAgctgaggtaaaatgagcttc	14	11	12	4	0	1	3	1	3	0	0	2	4	1	4	0	3	2	5	0	3	6	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr7:138602131A>G	uc011kql.1	-	2	2290	c.2241T>C	c.(2239-2241)GCT>GCC	p.A747A	KIAA1549_uc003vuk.3_Silent_p.A697A|KIAA1549_uc011kqj.1_Silent_p.A747A	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	747	Ser-rich.					integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TTTCAATGAAAGCTGAGGTAA	0.473			O	BRAF	pilocytic astrocytoma								7	38					0	0	0	0	G	138602131	G	G	138602131	2	3	161	1	0	0	0	0	0	0	0	1	8283	59	3	5		5	KIAA1549	7	138602131	Silent	SNP	A	TCGA-CR-7395-01A-11D-2012-08	6409344	138602131	20536532	85	29329											
GIMAP4	55303	broad.mit.edu	37	chr7	150269980	150269980	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gataaagtggagcaggaaaaGagaaagaagcaaatggagaa	22	3	14	2	0	0	3	0	0	0	3	0	8	0	5	0	3	2	2	0	3	8	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr7:150269980G>C	uc003whl.2	+	3	904	c.822G>C	c.(820-822)AAG>AAC	p.K274N	GIMAP4_uc011kuu.1_Missense_Mutation_p.K135N|GIMAP4_uc011kuv.1_Missense_Mutation_p.K288N	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	274	Potential.						GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCAGGAAAAGAGAAAGAAGC	0.463													3	20					0	0	0	0	C	150269980	C	C	150269980	3	2	161	1	0	0	0	0	1	0	0	0	6418	933	33	2	828	2	GIMAP4	7	150269980	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	11667849	150269980	8868683	86	29330											
AGPAT5	55326	broad.mit.edu	37	chr8	6566210	6566210	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atgctgctgtccctggtgctCcacacgtactccatgcgcta	6	11	9	15	2	0	0	0	0	0	0	3	0	3	0	3	1	5	5	3	1	2	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr8:6566210C>G	uc003wqo.2	+	1	333	c.21C>G	c.(19-21)CTC>CTG	p.L7L	AGPAT5_uc011kwm.1_Silent_p.L7L	NM_018361	NP_060831	Q9NUQ2	PLCE_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 5	7					phospholipid biosynthetic process	integral to membrane|mitochondrion	1-acylglycerol-3-phosphate O-acyltransferase activity				0			STAD - Stomach adenocarcinoma(24;0.0578)	READ - Rectum adenocarcinoma(644;0.156)|COAD - Colon adenocarcinoma(149;0.191)		CCCTGGTGCTCCACACGTACT	0.726											OREG0007035	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=AGPAT5|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	3	23					0	0	0	0	G	6566210	G	G	6566210	2	3	161	1	0	0	0	0	0	0	0	1	390	842	30	2		2	AGPAT5	8	6566210	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08		6566210	139797812	87	29331											
EBF2	64641	broad.mit.edu	37	chr8	25902267	25902267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgcgcggcgacattagcgtCcaccactccgacattccgga	8	7	10	16	6	0	0	0	0	0	0	3	3	3	1	4	2	2	0	4	2	1	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr8:25902267C>T	uc003xes.1	-	1	126	c.109G>A	c.(109-111)GAC>AAC	p.D37N	PPP2R2A_uc003xek.2_Intron|EBF2_uc003xet.1_Missense_Mutation_p.D37N	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	37					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		ACATTAGCGTCCACCACTCCG	0.567													6	104					0	0	0	0	T	25902267	T	T	25902267	3	4	161	1	0	0	0	0	1	0	0	0	4903	855	30	2	1682	2	EBF2	8	25902267	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	19336057	25902267	120461755	88	29332											
ELP3	55140	broad.mit.edu	37	chr8	27995259	27995259	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtcccgatgggctgaaactCtatcctaccctggtgattcg	7	11	10	13	3	1	2	0	2	1	0	4	3	3	2	3	2	2	1	3	2	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr8:27995259C>T	uc003xgo.3	+	10	1099	c.951C>T	c.(949-951)CTC>CTT	p.L317L	ELP3_uc003xgn.3_Silent_p.L302L|ELP3_uc011laq.1_Silent_p.L245L|ELP3_uc011lar.1_Silent_p.L225L|ELP3_uc011las.1_Silent_p.L198L|ELP3_uc011lat.1_Silent_p.L198L	NM_018091	NP_060561	Q9H9T3	ELP3_HUMAN	elongation protein 3 homolog	317					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding				0		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		GGCTGAAACTCTATCCTACCC	0.458													6	72					0	0	0	0	T	27995259	T	T	27995259	2	4	161	1	0	0	0	0	0	0	0	1	5105	900	32	2		2	ELP3	8	27995259	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	2092992	27995259	118368763	89	29333											
RNF122	79845	broad.mit.edu	37	chr8	33408567	33408568	+	Frame_Shift_Ins	INS	-	T	T																															cctggcacacttaccccataINStaattgtaacttcttggcat																										TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr8:33408567_33408568insT	uc003xjo.1	-	4	666_667	c.264_265insA	c.(262-267)TTATATfs	p.L88fs		NM_024787	NP_079063	Q9H9V4	RN122_HUMAN	ring finger protein 122	88_89						endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		CTTACCCCATATAATTGTAACT	0.51													---	---	---								T	33408568	T	T	33408567	7	5	161	1	0	1	1	0	0	0	0	0	13497	449	16	0	214	0	RNF122	8	33408567	Frame_Shift_Ins	INS	-	TCGA-CR-7395-01A-11D-2012-08	5413308	33408567	112955455	90	29334											
ZFHX4	79776	broad.mit.edu	37	chr8	77761784	77761784	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	attgtaactacaatagtaggGaccaaagtcgtatccagatg	15	10	9	7	1	0	1	0	0	0	1	2	2	1	2	2	1	2	3	2	1	7	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr8:77761784G>A	uc003yav.2	+	8	3934	c.3547G>A	c.(3547-3549)GAC>AAC	p.D1183N	ZFHX4_uc003yau.1_Missense_Mutation_p.D1228N|ZFHX4_uc003yaw.1_Missense_Mutation_p.D1183N	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1183	C2H2-type 8.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAATAGTAGGGACCAAAGTCG	0.388										HNSCC(33;0.089)			8	77					0	0	0	0	A	77761784	A	A	77761784	3	1	161	1	0	0	0	0	1	0	0	0	17702	1174	41	2	3708	2	ZFHX4	8	77761784	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	44353217	77761784	68602238	91	29335											
TM7SF4	81501	broad.mit.edu	37	chr8	105367220	105367220	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacctgggttcctctcagtgTtattcttttgatattagtga	7	18	9	7	0	2	2	1	2	2	0	4	3	3	2	2	1	0	2	2	1	3	7			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr8:105367220T>G	uc003ylx.1	+	3	1194	c.1145T>G	c.(1144-1146)GTT>GGT	p.V382G		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	382	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCTCTCAGTGTTATTCTTTTG	0.403													3	77					0	0	0	0	G	105367220	G	G	105367220	3	3	161	1	0	0	0	0	1	0	0	0	16042	1725	60	5	1151	5	TM7SF4	8	105367220	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	27605436	105367220	40996802	92	29336											
ACO1	48	broad.mit.edu	37	chr9	32423409	32423409	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acccttctcaagacccagacTtcacccaggtatgagagtgc	11	8	8	14	0	2	3	2	1	1	3	3	4	2	3	3	1	1	1	3	1	2	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:32423409T>G	uc003zqw.3	+	9	1218	c.1063T>G	c.(1063-1065)TTC>GTC	p.F355V	ACO1_uc010mjh.1_Missense_Mutation_p.F189V|ACO1_uc003zqx.3_Missense_Mutation_p.F355V|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	355					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		AGACCCAGACTTCACCCAGGT	0.418													6	105					0	0	0	0	G	32423409	G	G	32423409	3	3	161	1	0	0	0	0	1	0	0	0	146	1609	56	5	1093	5	ACO1	9	32423409	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08		32423409	108790022	93	29337											
TAF1L	138474	broad.mit.edu	37	chr9	32633618	32633618	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttagcaaaggttggactgAatggggacctggctgagaga	11	9	15	6	0	0	3	0	2	0	1	0	6	0	5	1	5	1	3	1	5	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:32633618A>C	uc003zrg.1	-	1	2050	c.1960T>G	c.(1960-1962)TCA>GCA	p.S654A	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	654					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGTTGGACTGAATGGGGACCT	0.498													5	136					0	0	0	0	C	32633618	C	C	32633618	3	2	161	1	0	0	0	0	1	0	0	0	15589	246	9	5	3524	5	TAF1L	9	32633618	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08	210209	32633618	108579813	94	29338											
PRSS3	5646	broad.mit.edu	37	chr9	33798053	33798053	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcactgagtgcctcatctccGgctggggcaacactctgagc	7	8	12	14	1	3	2	1	2	2	0	4	2	3	2	2	3	3	3	2	3	1	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:33798053G>A	uc003ztj.3	+	3	598	c.598G>A	c.(598-600)GGC>AGC	p.G200S	uc003ztk.1_Intron|PRSS3_uc003zti.3_Missense_Mutation_p.G157S|PRSS3_uc003ztl.3_Missense_Mutation_p.G143S	NM_007343	NP_031369	P35030	TRY3_HUMAN	mesotrypsin isoform 1 preproprotein	200	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity				0			LUSC - Lung squamous cell carcinoma(29;0.0176)			CCTCATCTCCGGCTGGGGCAA	0.567													5	102					0	0	0	0	A	33798053	A	A	33798053	3	1	161	1	0	0	0	0	1	0	0	0	12684	1116	39	1	652	1	PRSS3	9	33798053	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	1164435	33798053	107415378	95	29339											
FANCG	2189	broad.mit.edu	37	chr9	35074164	35074164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaaggaaggcgtcacgatCagagggacggatccagctca	12	6	13	10	3	4	1	4	0	0	1	5	5	5	4	1	4	1	1	1	4	2	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:35074164C>T	uc003zwb.1	-	14	2302	c.1810G>A	c.(1810-1812)GAT>AAT	p.D604N	VCP_uc003zvy.2_5'Flank|VCP_uc003zvz.2_5'Flank|VCP_uc010mkh.1_5'Flank|VCP_uc010mki.1_5'Flank|FANCG_uc003zwa.1_Missense_Mutation_p.D346N|FANCG_uc010mkj.1_Missense_Mutation_p.D346N	NM_004629	NP_004620	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	604					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|large_intestine(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCGTCACGATCAGAGGGACGG	0.517			Mis|N|F|S			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				7	57					0	0	0	0	T	35074164	T	T	35074164	3	4	161	1	0	0	0	0	1	0	0	0	5700	826	29	2	62	2	FANCG	9	35074164	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	1276111	35074164	106139267	96	29340											
PTCH1	5727	broad.mit.edu	37	chr9	98209652	98209652	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgctggccttgccgtcCgggaggcagggaccctgagt	4	7	18	12	2	0	1	0	1	0	0	1	3	1	3	4	5	2	3	4	5	0	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:98209652C>T	uc004avk.3	-	23	4074	c.3886G>A	c.(3886-3888)GGA>AGA	p.G1296R	PTCH1_uc010mrn.2_Missense_Mutation_p.G88R|PTCH1_uc010mro.2_Missense_Mutation_p.G1145R|PTCH1_uc010mrp.2_Missense_Mutation_p.G1145R|PTCH1_uc010mrq.2_Missense_Mutation_p.G1145R|PTCH1_uc004avl.3_Missense_Mutation_p.G1145R|PTCH1_uc010mrr.2_Missense_Mutation_p.G1230R|PTCH1_uc004avm.3_Missense_Mutation_p.G1295R	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1296	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CCTTGCCGTCCGGGAGGCAGG	0.652									Basal_Cell_Nevus_syndrome				17	92					0	0	0	0	T	98209652	T	T	98209652	3	4	161	1	0	0	0	0	1	0	0	0	12792	661	23	1	461	1	PTCH1	9	98209652	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	63135488	98209652	43003779	97	29341											
NCBP1	4686	broad.mit.edu	37	chr9	100425264	100425264	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtcttcaaaaccctagctGaaagtgatgaaggaaagtta	17	9	9	6	0	2	3	1	3	1	0	2	4	2	4	1	1	2	2	1	1	8	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:100425264G>A	uc004axq.2	+	18	2191	c.1732G>A	c.(1732-1734)GAA>AAA	p.E578K		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	578					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				AACCCTAGCTGAAAGTGATGA	0.323													8	61					0	0	0	0	A	100425264	A	A	100425264	3	1	161	1	0	0	0	0	1	0	0	0	10265	1291	45	2	1802	2	NCBP1	9	100425264	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	2215612	100425264	40788167	98	29342											
ALDOB	229	broad.mit.edu	37	chr9	104187258	104187258	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggctttggtagagggcaaAggttgatagcattgaggttg	10	11	17	3	0	0	3	0	2	0	1	0	3	0	3	0	5	1	6	0	5	3	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:104187258A>C	uc004bbk.2	-	8	948	c.866T>G	c.(865-867)CTT>CGT	p.L289R		NM_000035	NP_000026	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	289					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				TAGAGGGCAAAGGTTGATAGC	0.522													3	66					0	0	0	0	C	104187258	C	C	104187258	3	2	161	1	0	0	0	0	1	0	0	0	508	72	3	5	236	5	ALDOB	9	104187258	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08	3761994	104187258	37026173	99	29343											
TTLL11	158135	broad.mit.edu	37	chr9	124751885	124751885	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtcgataaggagaggtttGcagatgtactcctggaccac	10	11	12	8	1	0	2	0	0	0	2	2	5	1	3	2	3	2	3	2	3	2	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:124751885G>A	uc004blt.1	-	4	1316	c.1128C>T	c.(1126-1128)TGC>TGT	p.C376C	TTLL11_uc011lyl.1_Silent_p.C376C|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Silent_p.C53C|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	376	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						GGAGAGGTTTGCAGATGTACT	0.493													14	106					0	0	0	0	A	124751885	A	A	124751885	2	1	161	1	0	0	0	0	0	0	0	1	16792	1311	46	4		4	TTLL11	9	124751885	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	20564627	124751885	16461546	100	29344											
CRAT	1384	broad.mit.edu	37	chr9	131864310	131864310	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtgaggggtgtcccgtcActgtggtacacatccagctc	7	9	13	12	1	1	1	1	1	0	0	4	1	3	1	2	3	2	3	2	3	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:131864310A>G	uc004bxh.2	-	6	939	c.657T>C	c.(655-657)AGT>AGC	p.S219S	CRAT_uc004bxg.2_Silent_p.S198S|CRAT_uc004bxk.3_Silent_p.S198S	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	219					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	GTGTCCCGTCACTGTGGTACA	0.572													5	31					0	0	0	0	G	131864310	G	G	131864310	2	3	161	1	0	0	0	0	0	0	0	1	3862	156	6	5		5	CRAT	9	131864310	Silent	SNP	A	TCGA-CR-7395-01A-11D-2012-08	7112425	131864310	9349121	101	29345											
PMPCA	23203	broad.mit.edu	37	chr9	139316332	139316332	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacatcaatgctcatgatgAacctggaatccaggcctgtg	11	10	10	10	0	2	3	2	3	0	0	3	4	3	4	3	2	2	1	3	2	3	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:139316332A>T	uc004chl.2	+	12	1317	c.1312A>T	c.(1312-1314)AAC>TAC	p.N438Y	PMPCA_uc010nbl.2_Missense_Mutation_p.N338Y|PMPCA_uc011mdz.1_Missense_Mutation_p.N307Y|PMPCA_uc004chn.1_Missense_Mutation_p.N35Y	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	438					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		GCTCATGATGAACCTGGAATC	0.622													11	71					0	0	0	0	T	139316332	T	T	139316332	3	4	161	1	0	0	0	0	1	0	0	0	12195	246	9	5	1358	5	PMPCA	9	139316332	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08	7452022	139316332	1897099	102	29346											
NOTCH1	4851	broad.mit.edu	37	chr9	139392000	139392000	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccgggcggccagaaacaggGgtgtctcctcctgggggatg	6	6	17	12	2	1	1	0	0	1	1	3	2	2	2	4	6	1	0	4	6	1	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr9:139392000G>A	uc004chz.2	-	34	6191	c.6191C>T	c.(6190-6192)CCC>CTC	p.P2064L		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2064	ANK 5.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CAGAAACAGGGGTGTCTCCTC	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			3	20					0	0	0	0	A	139392000	A	A	139392000	3	1	161	1	0	0	0	0	1	0	0	0	10601	1232	43	4	1480	4	NOTCH1	9	139392000	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	75668	139392000	1821431	103	29347											
DNAJC1	64215	broad.mit.edu	37	chr10	22048479	22048479	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtgatcatgtcatcgggcaAggtggtggccgttttgatgg	6	12	17	6	2	2	2	2	2	0	0	3	2	2	2	1	6	0	2	1	6	1	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr10:22048479A>C	uc001irc.2	-	11	1503	c.1216T>G	c.(1216-1218)TTG>GTG	p.L406V	DNAJC1_uc001ird.2_Missense_Mutation_p.L292V	NM_022365	NP_071760	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	406	Cytoplasmic (By similarity).				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			lung(1)	1		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				TCATCGGGCAAGGTGGTGGCC	0.587													9	51					0	0	0	0	C	22048479	C	C	22048479	3	2	161	1	0	0	0	0	1	0	0	0	4650	69	3	5	456	5	DNAJC1	10	22048479	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08		22048479	113486268	104	29348											
MYO3A	53904	broad.mit.edu	37	chr10	26417382	26417382	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggctttgaaaatttcaaaaAaaattccttcgagcagctgt	14	13	7	7	1	1	1	1	1	0	0	3	2	2	1	1	1	2	3	1	1	6	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr10:26417382A>C	uc001isn.2	+	20	2537	c.2177A>C	c.(2176-2178)AAA>ACA	p.K726T	MYO3A_uc009xko.1_Missense_Mutation_p.K726T|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	726	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AATTTCAAAAAAAATTCCTTC	0.338													6	47					0	0	0	0	C	26417382	C	C	26417382	3	2	161	1	0	0	0	0	1	0	0	0	10129	14	1	5	2247	5	MYO3A	10	26417382	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08	4368903	26417382	109117365	105	29349											
JMJD1C	221037	broad.mit.edu	37	chr10	64967812	64967812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggtgggtgaaatactggtGctctatgtaatgcaggcata	10	13	13	5	0	1	1	0	1	1	0	1	1	1	1	0	4	3	4	0	4	5	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr10:64967812G>A	uc001jmn.2	-	10	3917	c.3617C>T	c.(3616-3618)GCA>GTA	p.A1206V	JMJD1C_uc001jml.2_Missense_Mutation_p.A987V|JMJD1C_uc001jmm.2_Missense_Mutation_p.A918V|JMJD1C_uc010qiq.1_Missense_Mutation_p.A1024V|JMJD1C_uc009xpi.2_Missense_Mutation_p.A1024V|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.A243V	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1206					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					AAATACTGGTGCTCTATGTAA	0.438													21	99					0	0	0	0	A	64967812	A	A	64967812	3	1	161	1	0	0	0	0	1	0	0	0	7989	1319	46	4	4073	4	JMJD1C	10	64967812	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	38550430	64967812	70566935	106	29350											
CBARA1	10367	broad.mit.edu	37	chr10	74322720	74322720	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaggggcaagatctgcagtcTttttctcatggttacaaaca	11	12	10	8	0	3	1	1	0	3	1	4	2	3	1	0	3	3	3	0	3	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr10:74322720T>G	uc001jtb.1	-	3	396	c.263A>C	c.(262-264)AAG>ACG	p.K88T		NM_006077	NP_006068	Q9BPX6	MICU1_HUMAN	calcium binding atopy-related autoantigen 1	88					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			ovary(1)	1						ATCTGCAGTCTTTTTCTCATG	0.403													3	24					0	0	0	0	G	74322720	G	G	74322720	3	3	161	1	0	0	0	0	1	0	0	0	2708	1609	56	5	1213	5	CBARA1	10	74322720	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	9354908	74322720	61212027	107	29351											
STAMBPL1	57559	broad.mit.edu	37	chr10	90665380	90665380	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtatttggaagaaggaaatTtggaaaatgcctttgttctt	12	16	10	3	0	1	1	0	0	1	1	1	4	1	4	1	3	1	2	1	3	6	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr10:90665380T>A	uc001kfk.2	+	3	634	c.211T>A	c.(211-213)TTG>ATG	p.L71M	STAMBPL1_uc010qmx.1_Missense_Mutation_p.L71M|STAMBPL1_uc009xto.2_RNA|STAMBPL1_uc001kfl.2_Missense_Mutation_p.L71M|STAMBPL1_uc001kfm.2_5'Flank	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	71							metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		AGAAGGAAATTTGGAAAATGC	0.338													9	43					0	0	0	0	A	90665380	A	A	90665380	3	1	161	1	0	0	0	0	1	0	0	0	15317	1838	64	5	217	5	STAMBPL1	10	90665380	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	16342660	90665380	44869367	108	29352											
LIPA	3988	broad.mit.edu	37	chr10	91005441	91005441	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttcccatacctttgtcaGaatggttcttcctcccatga	7	14	6	14	0	2	2	1	1	1	1	5	2	5	2	5	1	1	1	5	1	2	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr10:91005441G>C	uc001kga.3	-	3	389	c.221C>G	c.(220-222)TCT>TGT	p.S74C	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|LIPA_uc009xtq.2_Missense_Mutation_p.S74C	NM_000235	NP_000226	P38571	LICH_HUMAN	lipase A precursor	74					lipid catabolic process	lysosome	lipase activity|sterol esterase activity				0		Colorectal(252;0.0162)		GBM - Glioblastoma multiforme(2;0.00406)		ACCTTTGTCAGAATGGTTCTT	0.383													11	91					0	0	0	0	C	91005441	C	C	91005441	3	2	161	1	0	0	0	0	1	0	0	0	8861	942	33	2	1010	2	LIPA	10	91005441	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	340061	91005441	44529306	109	29353											
ZNF518A	9849	broad.mit.edu	37	chr10	97917735	97917735	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatgagaaaagtgtatcttcTttgtcagcaacatcagaatt	14	14	7	6	0	4	2	2	1	2	2	4	3	4	2	0	0	2	2	0	0	6	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr10:97917735T>C	uc001klp.2	+	6	2513	c.1656T>C	c.(1654-1656)TCT>TCC	p.S552S	ZNF518A_uc001klo.1_Silent_p.S22S|ZNF518A_uc001klq.2_Silent_p.S552S|ZNF518A_uc001klr.2_Silent_p.S552S	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	552					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		GTGTATCTTCTTTGTCAGCAA	0.338													7	72					0	0	0	0	C	97917735	C	C	97917735	2	2	161	1	0	0	0	0	0	0	0	1	18029	1596	56	5		5	ZNF518A	10	97917735	Silent	SNP	T	TCGA-CR-7395-01A-11D-2012-08	6912294	97917735	37617012	110	29354											
PDCD11	22984	broad.mit.edu	37	chr10	105205279	105205279	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggccctggagtatgtggaGgccaagagctcagtgctaga	11	7	15	8	0	1	2	1	0	0	2	1	4	1	4	2	4	2	3	2	4	4	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr10:105205279G>A	uc001kwy.1	+	36	5676	c.5589G>A	c.(5587-5589)GAG>GAA	p.E1863E		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1863					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		AGTATGTGGAGGCCAAGAGCT	0.597													7	51					0	0	0	0	A	105205279	A	A	105205279	2	1	161	1	0	0	0	0	0	0	0	1	11671	991	35	4		4	PDCD11	10	105205279	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	7287544	105205279	30329468	111	29355											
CPXM2	119587	broad.mit.edu	37	chr10	125530458	125530458	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgctccccagggtgatctGagatctccacagcatacagc	10	8	9	14	0	2	2	0	2	2	1	4	3	3	2	3	1	4	2	3	1	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr10:125530458G>A	uc001lhk.1	-	8	1401	c.1076C>T	c.(1075-1077)TCA>TTA	p.S359L	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	359					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		AGGGTGATCTGAGATCTCCAC	0.478													38	258					0	0	0	0	A	125530458	A	A	125530458	3	1	161	1	0	0	0	0	1	0	0	0	3853	1294	45	2	1222	2	CPXM2	10	125530458	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	20325179	125530458	10004289	112	29356											
GPR123	84435	broad.mit.edu	37	chr10	134942326	134942326	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggacgcccaccccgcacttGacgccaacggggccgcgctg	7	3	13	18	6	0	1	0	1	0	0	0	2	0	2	5	3	1	2	5	3	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr10:134942326G>A	uc001llx.3	+	7	1430	c.994G>A	c.(994-996)GAC>AAC	p.D332N	GPR123_uc001llw.2_Missense_Mutation_p.D1051N	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	332	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CCCCGCACTTGACGCCAACGG	0.731													8	37					0	0	0	0	A	134942326	A	A	134942326	3	1	161	1	0	0	0	0	1	0	0	0	6675	1290	45	2	1016	2	GPR123	10	134942326	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	9411868	134942326	592421	113	29357											
HRAS	3265	broad.mit.edu	37	chr11	534288	534288	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgcactcttgcccacaccgCcggcgcccaccaccaccagc	7	3	8	23	4	1	0	0	0	1	0	1	0	1	0	7	1	2	1	7	1	0	1	rs104894230		TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr11:534288C>T	uc001lpv.2	-	2	223	c.35G>A	c.(34-36)GGC>GAC	p.G12D	HRAS_uc010qvw.1_Missense_Mutation_p.G12D|HRAS_uc010qvx.1_Missense_Mutation_p.G12D|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	12	GTP.		G -> S (in FCSS, OSCC and CMEMS).|G -> E (in FCSS).|G -> C (in FCSS).|G -> A (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12V(250)|p.G12S(54)|p.G12D(40)|p.G12C(23)|p.G12R(12)|p.G12A(7)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GCCCACACCGCCGGCGCCCAC	0.647	G12V(T24_URINARY_TRACT)|G12D(HS578T_BREAST)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			5	40					0	0	0	0	T	534288	T	T	534288	3	4	161	1	0	0	0	0	1	0	0	0	7387	739	26	4	617	4	HRAS	11	534288	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08		534288	134472228	114	29358											
OR51A2	401667	broad.mit.edu	37	chr11	4976514	4976514	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatactatccctatttgggCaactctgacagttgtcagga	11	12	9	9	0	2	1	1	1	1	0	3	3	3	2	1	2	2	2	1	2	5	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr11:4976514C>T	uc010qyt.1	-	1	430	c.430G>A	c.(430-432)GCC>ACC	p.A144T		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTATTTGGGCAACTCTGACA	0.423													34	121					0	0	0	0	T	4976514	T	T	4976514	3	4	161	1	0	0	0	0	1	0	0	0	11140	710	25	4	513	4	OR51A2	11	4976514	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	4442226	4976514	130030002	115	29359											
OR8J3	81168	broad.mit.edu	37	chr11	55904603	55904603	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctgcagatataaagactaTtgtttctggtatgtaagtat	12	16	9	4	0	1	2	0	0	1	2	1	2	1	2	0	1	2	6	0	1	7	8			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr11:55904603T>C	uc010riz.1	-	1	592	c.592A>G	c.(592-594)ATA>GTA	p.I198V		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					ATAAAGACTATTGTTTCTGGT	0.318													12	81					0	0	0	0	C	55904603	C	C	55904603	3	2	161	1	0	0	0	0	1	0	0	0	11296	1493	52	5	357	5	OR8J3	11	55904603	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	50928089	55904603	79101913	116	29360											
OR8H1	219469	broad.mit.edu	37	chr11	56058468	56058468	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagtataaagagggccatcTggacctcttcagaatctgac	13	10	9	9	0	4	3	1	1	3	2	4	4	4	4	2	2	0	1	2	2	5	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr11:56058468T>G	uc010rje.1	-	1	71	c.71A>C	c.(70-72)CAG>CCG	p.Q24P		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GAGGGCCATCTGGACCTCTTC	0.423													8	96					0	0	0	0	G	56058468	G	G	56058468	3	3	161	1	0	0	0	0	1	0	0	0	11291	1580	55	5	866	5	OR8H1	11	56058468	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	153865	56058468	78948048	117	29361											
ATM	472	broad.mit.edu	37	chr11	108121428	108121428	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcctttttttttttttttagGctacagattgcaacccaatt	8	21	4	8	0	0	1	0	0	0	1	1	1	1	1	2	1	3	2	2	1	4	11	rs79220522		TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr11:108121428G>C	uc001pkb.1	+	10	1621	c.1236G>C	c.(1234-1236)TGG>TGC	p.W412C	ATM_uc009yxr.1_Missense_Mutation_p.W412C	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	412					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTTTTTTTAGGCTACAGATTG	0.318			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			6	32					0	0	0	0	C	108121428	C	C	108121428	3	2	161	1	0	0	0	0	1	0	0	0	1111	1217	42	4	1270	4	ATM	11	108121428	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	52062960	108121428	26885088	118	29362											
IGSF9B	22997	broad.mit.edu	37	chr11	133791272	133791272	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgcggatgctctcggggCtcaccttgccagaggacaag	7	7	15	12	3	2	1	1	0	1	1	3	3	2	3	2	4	3	2	2	4	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr11:133791272C>T	uc001qgx.3	-	18	2579	c.2348G>A	c.(2347-2349)AGC>AAC	p.S783N		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	783	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GCTCTCGGGGCTCACCTTGCC	0.662													3	15					0	0	0	0	T	133791272	T	T	133791272	3	4	161	1	0	0	0	0	1	0	0	0	7645	797	28	4	1709	4	IGSF9B	11	133791272	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	25669844	133791272	1215244	119	29363											
DCP1B	196513	broad.mit.edu	37	chr12	2061959	2061959	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgggagctctgctgcggtTcagggcagctgagctggcag	6	8	18	9	1	2	1	1	1	1	0	2	2	2	2	0	4	5	7	0	4	0	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:2061959T>G	uc001qjx.1	-	7	1227	c.1147A>C	c.(1147-1149)AAC>CAC	p.N383H	DCP1B_uc010sdy.1_Missense_Mutation_p.N281H	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	383					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			CTGCTGCGGTTCAGGGCAGCT	0.572													19	67					0	0	0	0	G	2061959	G	G	2061959	3	3	161	1	0	0	0	0	1	0	0	0	4316	1783	62	5	718	5	DCP1B	12	2061959	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08		2061959	131789936	120	29364											
RAD51AP1	10635	broad.mit.edu	37	chr12	4668097	4668097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctcccaatcagagtctcCgccttggcttgtccagatta	8	12	8	13	1	3	2	1	0	2	2	6	2	4	2	4	1	0	1	4	1	2	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:4668097C>T	uc001qmw.2	+	10	1153	c.997C>T	c.(997-999)CGC>TGC	p.R333C	RAD51AP1_uc001qmu.2_Missense_Mutation_p.R316C|RAD51AP1_uc001qmv.2_Missense_Mutation_p.R279C|RAD51AP1_uc010sep.1_Missense_Mutation_p.R214C|RAD51AP1_uc010seq.1_Missense_Mutation_p.R214C|RAD51AP1_uc009zeg.2_RNA	NM_001130862	NP_001124334	Q96B01	R51A1_HUMAN	RAD51 associated protein 1 isoform a	333	Interaction with RAD51.			R->A: Strongly decreases interaction with RAD51; when associated with Q-336; A-345 and A-346.	double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|protein binding|RNA binding|single-stranded DNA binding				0			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			TCAGAGTCTCCGCCTTGGCTT	0.498													8	89					0	0	0	0	T	4668097	T	T	4668097	3	4	161	1	0	0	0	0	1	0	0	0	13051	652	23	1	1035	1	RAD51AP1	12	4668097	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	2606138	4668097	129183798	121	29365											
CD163	9332	broad.mit.edu	37	chr12	7639106	7639106	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataatttacctgagcagataActcccgcatcctccttgtgc	10	12	6	13	1	0	2	0	1	0	1	3	2	3	2	4	0	4	2	4	0	3	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:7639106A>C	uc001qsz.3	-	10	2575	c.2447T>G	c.(2446-2448)GTT>GGT	p.V816G	CD163_uc001qta.3_Missense_Mutation_p.V816G|CD163_uc009zfw.2_Missense_Mutation_p.V849G	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	816	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TGAGCAGATAACTCCCGCATC	0.443													4	130					0	0	0	0	C	7639106	C	C	7639106	3	2	161	1	0	0	0	0	1	0	0	0	2982	43	2	5	1051	5	CD163	12	7639106	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08	2971009	7639106	126212789	122	29366											
ARID2	196528	broad.mit.edu	37	chr12	46233280	46233280	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcatgtagcatctgccccagGttagtgttttcacatattct	8	16	7	10	0	4	0	2	0	2	0	4	0	4	0	2	1	2	4	2	1	3	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:46233280G>A	uc001ros.1	+	11	1498	c.1498_splice	c.e11+1	p.A500_splice	ARID2_uc001ror.2_Splice_Site_p.A500_splice|ARID2_uc009zkg.1_Splice_Site|ARID2_uc009zkh.1_Splice_Site_p.A127_splice|ARID2_uc001rot.1_Missense_Mutation_p.G146D	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCTGCCCCAGGTTAGTGTTTT	0.373													14	77					0	0	0	0	A	46233280	A	A	46233280	5	1	161	1	0	0	0	0	0	0	1	0	915	1275	44	4	1541	4	ARID2	12	46233280	Splice_Site	SNP	G	TCGA-CR-7395-01A-11D-2012-08	38594174	46233280	87618615	123	29367											
ARID2	196528	broad.mit.edu	37	chr12	46285669	46285669	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaggttgtgagccttttcagCgacagcggttttcttttatt	7	17	10	7	2	2	1	1	1	1	0	2	2	2	1	1	2	3	2	1	2	2	8			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:46285669C>T	uc001ros.1	+	17	5029	c.5029C>T	c.(5029-5031)CGA>TGA	p.R1677*	ARID2_uc001ror.2_Nonsense_Mutation_p.R1677*|ARID2_uc009zkg.1_Nonsense_Mutation_p.R1133*|ARID2_uc009zkh.1_Nonsense_Mutation_p.R1304*|ARID2_uc001rou.1_Nonsense_Mutation_p.R1011*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1677					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GCCTTTTCAGCGACAGCGGTT	0.413													9	92					0	0	0	0	T	46285669	T	T	46285669	4	4	161	1	0	0	0	0	0	1	0	0	915	760	27	1	5095	1	ARID2	12	46285669	Nonsense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	52389	46285669	87566226	124	29368											
POU6F1	5463	broad.mit.edu	37	chr12	51584078	51584078	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctggtgttcttgagcgtctgGcgccgattgcagaaccagac	7	10	13	11	3	2	3	0	1	2	2	2	4	2	3	2	2	3	2	2	2	1	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:51584078G>A	uc001rxy.2	-	5	1050	c.858C>T	c.(856-858)CGC>CGT	p.R286R	POU6F1_uc001rxz.2_Silent_p.R286R|POU6F1_uc001rya.2_Silent_p.R286R	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	286	Homeobox.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGAGCGTCTGGCGCCGATTGC	0.552													11	71					0	0	0	0	A	51584078	A	A	51584078	2	1	161	1	0	0	0	0	0	0	0	1	12339	1190	42	4		4	POU6F1	12	51584078	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	5298409	51584078	82267817	125	29369											
GALNT6	11226	broad.mit.edu	37	chr12	51752036	51752036	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcgttccgaaatgtcacCgaaggatttctgtcaatcaa	12	11	8	10	3	4	0	3	0	1	0	6	3	5	1	2	1	0	1	2	1	4	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:51752036C>A	uc001ryk.2	-	8	1603	c.1378G>T	c.(1378-1380)GGT>TGT	p.G460C	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Missense_Mutation_p.G460C|GALNT6_uc001ryj.1_Missense_Mutation_p.G25C	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	460	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GAAATGTCACCGAAGGATTTC	0.373													10	89					2.80697e-09	5.73037e-09	1	0	A	51752036	A	A	51752036	3	1	161	1	0	0	0	0	1	0	0	0	6252	652	23	3	506	3	GALNT6	12	51752036	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	167958	51752036	82099859	126	29370											
KRT83	3889	broad.mit.edu	37	chr12	52709762	52709762	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttcatcacctcctggtactCcctgatcaggcaggccatgt	7	11	9	14	0	3	1	3	1	0	0	5	1	5	1	4	3	1	3	4	3	1	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:52709762C>T	uc001saf.2	-	7	1240	c.1177G>A	c.(1177-1179)GAG>AAG	p.E393K		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	393	Rod.|Coil 2.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCCTGGTACTCCCTGATCAGG	0.647													9	123					0	0	0	0	T	52709762	T	T	52709762	3	4	161	1	0	0	0	0	1	0	0	0	8536	864	30	2	316	2	KRT83	12	52709762	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	957726	52709762	81142133	127	29371											
KCNC2	3747	broad.mit.edu	37	chr12	75601707	75601707	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtgctgcggtaggtttcGtgccgggtgcccccgacatt	4	10	16	11	4	0	0	0	0	0	0	1	1	0	0	3	4	4	3	3	4	1	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:75601707G>A	uc001sxg.1	-	2	601	c.57C>T	c.(55-57)CAC>CAT	p.H19H	KCNC2_uc009zry.2_Silent_p.H19H|KCNC2_uc001sxe.2_Silent_p.H19H|KCNC2_uc001sxf.2_Silent_p.H19H|KCNC2_uc010stw.1_Silent_p.H19H	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	19	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						GGTAGGTTTCGTGCCGGGTGC	0.632													5	65					0	0	0	0	A	75601707	A	A	75601707	2	1	161	1	0	0	0	0	0	0	0	1	8054	1136	40	1		1	KCNC2	12	75601707	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	22891945	75601707	58250188	128	29372											
MYBPC1	4604	broad.mit.edu	37	chr12	102064158	102064158	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctatatccgcagagttggaGaagctgtcaatctggttata	11	12	10	8	1	2	2	1	0	1	2	3	3	3	2	2	2	1	4	2	2	6	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:102064158G>A	uc001tii.2	+	23	2665	c.2563G>A	c.(2563-2565)GAA>AAA	p.E855K	MYBPC1_uc001tig.2_Missense_Mutation_p.E862K|MYBPC1_uc010svq.1_Missense_Mutation_p.E824K|MYBPC1_uc001tih.2_Missense_Mutation_p.E862K|MYBPC1_uc001tij.2_Missense_Mutation_p.E837K|MYBPC1_uc010svr.1_Missense_Mutation_p.E837K|MYBPC1_uc010svs.1_Missense_Mutation_p.E855K|MYBPC1_uc010svt.1_Missense_Mutation_p.E825K|MYBPC1_uc010svu.1_Missense_Mutation_p.E818K|MYBPC1_uc001tik.2_Missense_Mutation_p.E811K|MYBPC1_uc001til.2_5'UTR|MYBPC1_uc001tim.2_5'UTR	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	855	Ig-like C2-type 6.			EAVN -> DRVI (in Ref. 1; CAA46987).	cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						CAGAGTTGGAGAAGCTGTCAA	0.443													15	129					0	0	0	0	A	102064158	A	A	102064158	3	1	161	1	0	0	0	0	1	0	0	0	10064	943	33	2	2736	2	MYBPC1	12	102064158	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	26462451	102064158	31787737	129	29373											
PAH	5053	broad.mit.edu	37	chr12	103288646	103288646	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaattcatactcatctttCtttaaacgagaaggtctaga	16	13	5	7	1	5	2	2	0	3	2	5	3	5	2	0	1	2	0	0	1	7	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:103288646C>T	uc001tjq.1	-	4	691	c.219G>A	c.(217-219)AAG>AAA	p.K73K	PAH_uc010swc.1_Silent_p.K73K	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	73	ACT.				catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	ACTCATCTTTCTTTAAACGAG	0.443													14	57					0	0	0	0	T	103288646	T	T	103288646	2	4	161	1	0	0	0	0	0	0	0	1	11448	912	32	2		2	PAH	12	103288646	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	1224488	103288646	30563249	130	29374											
C12orf51	283450	broad.mit.edu	37	chr12	112690297	112690297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtgttcacggccacttctCatttcaaaggagaaggtgac	10	12	10	9	1	3	2	3	1	1	1	4	3	3	2	1	3	0	1	1	3	2	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr12:112690297C>T	uc009zwc.2	-	16	2235	c.2217G>A	c.(2215-2217)ATG>ATA	p.M739I	C12orf51_uc010syk.1_Missense_Mutation_p.M561I|C12orf51_uc001tts.2_Missense_Mutation_p.M552I|C12orf51_uc001ttt.3_Missense_Mutation_p.M550I	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GGCCACTTCTCATTTCAAAGG	0.438													14	94					0	0	0	0	T	112690297	T	T	112690297	3	4	161	1	0	0	0	0	1	0	0	0	1702	826	29	2	9989	2	C12orf51	12	112690297	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	9401651	112690297	21161598	131	29375											
PARP4	143	broad.mit.edu	37	chr13	25049615	25049615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacagacaacatacctgggCtacagtgtctatgattctcc	11	10	7	13	0	2	2	0	1	2	1	3	2	2	2	3	1	3	1	3	1	4	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr13:25049615C>T	uc001upl.2	-	15	2015	c.1909G>A	c.(1909-1911)GCC>ACC	p.A637T	PARP4_uc010tdc.1_Missense_Mutation_p.A637T	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	637	VIT.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		CATACCTGGGCTACAGTGTCT	0.458													13	69					0	0	0	0	T	25049615	T	T	25049615	3	4	161	1	0	0	0	0	1	0	0	0	11517	797	28	4	3345	4	PARP4	13	25049615	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08		25049615	90120263	132	29376											
FREM2	341640	broad.mit.edu	37	chr13	39264178	39264178	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggacataaaacagggccgAgtttcctatgcccataatgg	13	8	11	9	1	0	0	0	0	0	0	1	3	1	1	3	3	2	1	3	3	4	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr13:39264178A>G	uc001uwv.2	+	1	3006	c.2697A>G	c.(2695-2697)CGA>CGG	p.R899R		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	899	CSPG 5.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AACAGGGCCGAGTTTCCTATG	0.512													4	36					0	0	0	0	G	39264178	G	G	39264178	2	3	161	1	0	0	0	0	0	0	0	1	6079	291	11	5		5	FREM2	13	39264178	Silent	SNP	A	TCGA-CR-7395-01A-11D-2012-08	14214563	39264178	75905700	133	29377											
HNRNPA1L2	144983	broad.mit.edu	37	chr13	53217120	53217120	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgtggataagattgtcattCagaaataccatactgtgaag	14	11	9	7	1	2	3	2	1	0	2	2	4	2	4	2	1	2	0	2	1	5	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr13:53217120C>G	uc001vgx.1	+	7	1566	c.493C>G	c.(493-495)CAG>GAG	p.Q165E	HNRNPA1L2_uc001vgy.1_Missense_Mutation_p.Q165E|HNRNPA1L2_uc001vgz.1_Missense_Mutation_p.Q165E	NM_001011724	NP_001011724	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like	165	Globular B domain.|RRM 2.				mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding				0						GATTGTCATTCAGAAATACCA	0.468													7	63					0	0	0	0	G	53217120	G	G	53217120	3	3	161	1	0	0	0	0	1	0	0	0	7297	827	29	2	495	2	HNRNPA1L2	13	53217120	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	13952942	53217120	61952758	134	29378											
TBC1D4	9882	broad.mit.edu	37	chr13	75911119	75911119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctttatttttcagaatgtCaagtttgaaccttccactgc	10	16	6	9	0	2	2	2	1	0	1	3	2	3	2	2	0	3	2	2	0	4	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr13:75911119C>T	uc001vjl.1	-	8	2016	c.1669G>A	c.(1669-1671)GAC>AAC	p.D557N	TBC1D4_uc010aer.2_Missense_Mutation_p.D557N|TBC1D4_uc010aes.2_Missense_Mutation_p.D557N	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	557						cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		TTCAGAATGTCAAGTTTGAAC	0.333													8	42					0	0	0	0	T	75911119	T	T	75911119	3	4	161	1	0	0	0	0	1	0	0	0	15688	826	29	2	2283	2	TBC1D4	13	75911119	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	22693999	75911119	39258759	135	29379											
OR4K5	79317	broad.mit.edu	37	chr14	20389087	20389087	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttctttattcacctttttActggaggggagatggtgcta	7	18	10	6	0	2	1	1	0	1	1	2	3	2	2	1	4	2	1	1	4	3	9			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr14:20389087A>C	uc010tkw.1	+	1	322	c.322A>C	c.(322-324)ACT>CCT	p.T108P		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCACCTTTTTACTGGAGGGGA	0.428													18	241					0	0	0	0	C	20389087	C	C	20389087	3	2	161	1	0	0	0	0	1	0	0	0	11127	391	14	5	324	5	OR4K5	14	20389087	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08		20389087	86960453	136	29380											
OR4L1	122742	broad.mit.edu	37	chr14	20529070	20529070	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatccgagtatttataccctGagaaataagaaaatgcaaga	19	9	7	6	1	0	3	0	1	0	3	1	5	1	3	2	0	2	2	2	0	9	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr14:20529070G>A	uc001vwn.1	+	1	867	c.867G>A	c.(865-867)CTG>CTA	p.L289L		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TTTATACCCTGAGAAATAAGA	0.328													12	71					0	0	0	0	A	20529070	A	A	20529070	2	1	161	1	0	0	0	0	0	0	0	1	11128	1277	45	2		2	OR4L1	14	20529070	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	139983	20529070	86820470	137	29381											
ADCY4	196883	broad.mit.edu	37	chr14	24795367	24795367	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctagtccccggggggtacGgctcctgcacagtgagagcc	7	7	14	13	2	1	1	0	1	1	1	3	2	3	1	4	4	3	3	4	4	2	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr14:24795367G>A	uc001wov.2	-	12	1579	c.1573C>T	c.(1573-1575)CGT>TGT	p.R525C	ADCY4_uc001wow.2_Missense_Mutation_p.R525C|ADCY4_uc010toh.1_Missense_Mutation_p.R211C|ADCY4_uc001wox.2_Missense_Mutation_p.R525C|ADCY4_uc001woy.2_Missense_Mutation_p.R525C	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	525	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		CGGGGGGTACGGCTCCTGCAC	0.587													8	48					0	0	0	0	A	24795367	A	A	24795367	3	1	161	1	0	0	0	0	1	0	0	0	296	1116	39	1	1716	1	ADCY4	14	24795367	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	4266297	24795367	82554173	138	29382											
RALGAPA1	253959	broad.mit.edu	37	chr14	36039926	36039926	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccattcacaatagcaccatCaaaaaggggaccaaagaagg	18	5	8	10	0	2	1	2	0	0	1	3	2	3	2	3	3	1	1	3	3	6	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr14:36039926C>G	uc001wti.2	-	38	6266	c.5875G>C	c.(5875-5877)GAT>CAT	p.D1959H	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.D1959H|RALGAPA1_uc010tpv.1_Missense_Mutation_p.D1972H|RALGAPA1_uc010tpw.1_Missense_Mutation_p.D2006H	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1959	Minimal domain that binds to TCF3/E12 (By similarity).|Rap-GAP.				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						ATAGCACCATCAAAAAGGGGA	0.363													3	24					0	0	0	0	G	36039926	G	G	36039926	3	3	161	1	0	0	0	0	1	0	0	0	13078	826	29	2	400	2	RALGAPA1	14	36039926	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	11244559	36039926	71309614	139	29383											
PAPOLA	10914	broad.mit.edu	37	chr14	96994296	96994296	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactttccttataggctgttGaagaggcattcgtaccagtt	9	15	9	8	1	0	2	0	1	0	1	2	2	1	2	2	2	2	5	2	2	5	8			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr14:96994296G>A	uc001yfq.2	+	6	658	c.448G>A	c.(448-450)GAA>AAA	p.E150K	PAPOLA_uc001yfo.2_Missense_Mutation_p.E150K|PAPOLA_uc001yfp.2_Missense_Mutation_p.E150K|PAPOLA_uc001yfr.2_Missense_Mutation_p.E150K|PAPOLA_uc010twv.1_Missense_Mutation_p.E150K|PAPOLA_uc010avp.2_Intron	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	150					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		ATAGGCTGTTGAAGAGGCATT	0.353													24	100					0	0	0	0	A	96994296	A	A	96994296	3	1	161	1	0	0	0	0	1	0	0	0	11483	1291	45	2	470	2	PAPOLA	14	96994296	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	60954370	96994296	10355244	140	29384											
MTA1	9112	broad.mit.edu	37	chr14	105916417	105916417	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaatagaagaggaaatggaGaacccggaaatggtggacct	17	5	14	5	1	0	3	0	0	0	3	0	8	0	6	2	5	1	0	2	5	6	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr14:105916417G>A	uc001yqx.2	+	5	451	c.264G>A	c.(262-264)GAG>GAA	p.E88E	MTA1_uc001yqy.2_RNA|MTA1_uc001yqz.1_Silent_p.E2E|MTA1_uc001yra.1_Silent_p.E2E	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	88	BAH.				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		AGGAAATGGAGAACCCGGAAA	0.627													10	66					0	0	0	0	A	105916417	A	A	105916417	2	1	161	1	0	0	0	0	0	0	0	1	9961	933	33	2		2	MTA1	14	105916417	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	8922121	105916417	1433123	141	29385											
MTA1	9112	broad.mit.edu	37	chr14	105927207	105927207	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tctgcagggacgagatggagGagtggtctgcatcagaggcc	9	7	17	8	1	3	2	1	0	2	2	3	6	3	5	1	5	2	2	1	5	0	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr14:105927207G>C	uc001yqx.2	+	10	1046	c.859G>C	c.(859-861)GAG>CAG	p.E287Q	MTA1_uc001yqy.2_RNA|MTA1_uc001yqz.1_Missense_Mutation_p.E201Q|MTA1_uc001yra.1_Missense_Mutation_p.E201Q|MTA1_uc001yrb.2_Missense_Mutation_p.E48Q	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	287	SANT.				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CGAGATGGAGGAGTGGTCTGC	0.562													4	118					0	0	0	0	C	105927207	C	C	105927207	3	2	161	1	0	0	0	0	1	0	0	0	9961	1175	41	2	897	2	MTA1	14	105927207	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	10790	105927207	1422333	142	29386											
C15orf2	23742	broad.mit.edu	37	chr15	24923550	24923550	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctttgtctccaggaaggagGagtacatccgattttatatg	10	13	10	8	1	1	0	0	0	1	0	3	4	2	3	3	3	1	1	3	3	4	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr15:24923550G>A	uc001ywo.2	+	1	3010	c.2536G>A	c.(2536-2538)GAG>AAG	p.E846K		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	846					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CAGGAAGGAGGAGTACATCCG	0.502													12	98					0	0	0	0	A	24923550	A	A	24923550	3	1	161	1	0	0	0	0	1	0	0	0	1790	1175	41	2	2538	2	C15orf2	15	24923550	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08		24923550	77607842	143	29387											
GABRB3	2562	broad.mit.edu	37	chr15	26806250	26806250	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtacatgtcaatggctttGacataggggattttgggcaa	11	12	13	5	0	1	1	1	1	0	0	1	2	1	2	0	5	1	3	0	5	4	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr15:26806250G>C	uc001zaz.2	-	8	1051	c.909C>G	c.(907-909)GTC>GTG	p.V303V	GABRB3_uc010uae.1_Silent_p.V218V|GABRB3_uc001zba.2_Silent_p.V303V|GABRB3_uc001zbb.2_Silent_p.V359V	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	303					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAATGGCTTTGACATAGGGGA	0.478													13	94					0	0	0	0	C	26806250	C	C	26806250	2	2	161	1	0	0	0	0	0	0	0	1	6202	1277	45	2		2	GABRB3	15	26806250	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	1882700	26806250	75725142	144	29388											
C15orf52	388115	broad.mit.edu	37	chr15	40630982	40630982	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatggtcacagccagctcCaccagctcccctaagcagaa	11	6	7	17	0	1	1	1	0	0	1	4	1	4	1	6	1	4	3	6	1	2	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr15:40630982C>T	uc001zlh.3	-	4	502	c.486G>A	c.(484-486)GTG>GTA	p.V162V	C15orf52_uc001zli.1_Silent_p.V94V|C15orf52_uc010ucn.1_5'Flank	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	162										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CAGCCAGCTCCACCAGCTCCC	0.607													11	50					0	0	0	0	T	40630982	T	T	40630982	2	4	161	1	0	0	0	0	0	0	0	1	1806	581	21	4		4	C15orf52	15	40630982	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	13824732	40630982	61900410	145	29389											
EXD1	161829	broad.mit.edu	37	chr15	41476415	41476416	+	Missense_Mutation	DNP	TC	AT	AT																															tctgagttattctctggtccTctgacccctttgactttgtg																										TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr15:41476415_41476416TC>AT	uc001znk.2	-	10	1449_1450	c.1258_1259GA>AT	c.(1258-1260)GAG>ATG	p.E420M	EXD1_uc001znj.2_Missense_Mutation_p.E218M|EXD1_uc010ucv.1_Missense_Mutation_p.E478M	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	420					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						TCTCTGGTCCTCTGACCCCTTT	0.416													21	137					0	0	0	0	AT	41476416	AT	AT	41476415	3	1	161	1	0	0	0	0	1	0	0	0	5321	1551	54	5	289	5	EXD1	15	41476415	Missense_Mutation	DNP	TC	TCGA-CR-7395-01A-11D-2012-08	845433	41476415	61054977	146	29390											
NMB	4828	broad.mit.edu	37	chr15	85201312	85201312	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatcccagctgagcggggcGacgccggcagcgagcagggc	8	2	18	13	5	0	2	0	1	0	1	1	4	1	2	2	4	4	3	2	4	0	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr15:85201312G>A	uc002bkz.2	-	1	491	c.72C>T	c.(70-72)GTC>GTT	p.V24V	NMB_uc002bla.2_Silent_p.V24V	NM_021077	NP_066563	P08949	NMB_HUMAN	neuromedin B isoform 1	24					cell-cell signaling|neuropeptide signaling pathway	extracellular region|soluble fraction	hormone activity				0				all cancers(203;3.5e-06)		TGAGCGGGGCGACGCCGGCAG	0.622													5	17					0	0	0	0	A	85201312	A	A	85201312	2	1	161	1	0	0	0	0	0	0	0	1	10540	1045	37	1		1	NMB	15	85201312	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	43724897	85201312	17330080	147	29391											
MAN2A2	4122	broad.mit.edu	37	chr15	91448552	91448552	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggagaaccatgagattatCagccatatcaaggactccgt	14	8	10	9	1	2	2	2	1	0	2	3	6	3	3	3	2	2	0	3	2	4	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr15:91448552C>T	uc010bnz.2	+	3	319	c.204C>T	c.(202-204)ATC>ATT	p.I68I	MAN2A2_uc010boa.2_Silent_p.I110I|MAN2A2_uc002bqc.2_Silent_p.I68I|MAN2A2_uc010uql.1_5'Flank|MAN2A2_uc010uqm.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	68	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			ATGAGATTATCAGCCATATCA	0.552													11	107					0	0	0	0	T	91448552	T	T	91448552	2	4	161	1	0	0	0	0	0	0	0	1	9268	816	29	2		2	MAN2A2	15	91448552	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	6247240	91448552	11082840	148	29392											
SPSB3	90864	broad.mit.edu	37	chr16	1831369	1831369	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaacctacctgcccatcaGagtcgtagccccagttagtg	9	9	10	13	1	1	1	1	0	0	1	2	2	1	2	5	1	4	2	5	1	4	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:1831369G>A	uc002cmr.2	-	1	149	c.116C>T	c.(115-117)TCT>TTT	p.S39F	NUBP2_uc002cmw.3_5'Flank|NUBP2_uc002cmx.3_5'Flank|NUBP2_uc010brx.2_5'Flank|SPSB3_uc002cms.2_5'UTR|SPSB3_uc002cmt.2_5'UTR|SPSB3_uc002cmu.2_Missense_Mutation_p.S39F|SPSB3_uc002cmv.2_5'UTR|SPSB3_uc010uvm.1_Missense_Mutation_p.S39F	NM_080861	NP_543137	Q6PJ21	SPSB3_HUMAN	splA/ryanodine receptor domain and SOCS box	39					intracellular signal transduction						0						CTGCCCATCAGAGTCGTAGCC	0.642													6	59					0	0	0	0	A	1831369	A	A	1831369	3	1	161	1	0	0	0	0	1	0	0	0	15180	942	33	2	975	2	SPSB3	16	1831369	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08		1831369	88523384	149	29393											
MPV17L	255027	broad.mit.edu	37	chr16	15501680	15501680	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttttttttcccaattccaGagtggactgatgtactggcc	7	17	8	9	0	0	2	0	1	0	1	2	3	2	3	3	2	1	1	3	2	2	7	rs144408494		TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:15501680G>A	uc002ddn.2	+	3	526	c.382_splice	c.e3-1	p.S128_splice	MPV17L_uc002ddm.2_Splice_Site_p.E104_splice	NM_001128423	NP_001121895	Q2QL34	MP17L_HUMAN	MPV17 mitochondrial membrane protein-like							integral to membrane|peroxisomal membrane					0						CCCAATTCCAGAGTGGACTGA	0.308													6	37					0	0	0	0	A	15501680	A	A	15501680	5	1	161	1	0	0	0	0	0	0	1	0	9799	956	33	2	391	2	MPV17L	16	15501680	Splice_Site	SNP	G	TCGA-CR-7395-01A-11D-2012-08	13670311	15501680	74853073	150	29394											
ABCC6	368	broad.mit.edu	37	chr16	16302657	16302657	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcttctgaggagttttctCtcccaagcgaccagaggtct	7	13	10	11	1	4	2	0	1	4	1	6	4	5	3	2	2	1	2	2	2	1	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:16302657C>T	uc002den.3	-	7	759	c.722G>A	c.(721-723)AGA>AAA	p.R241K	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Missense_Mutation_p.R253K	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	241	Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GGAGTTTTCTCTCCCAAGCGA	0.552													6	58					0	0	0	0	T	16302657	T	T	16302657	3	4	161	1	0	0	0	0	1	0	0	0	57	913	32	2	3889	2	ABCC6	16	16302657	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	800977	16302657	74052096	151	29395											
POLR3E	55718	broad.mit.edu	37	chr16	22320755	22320755	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccctgtgctccaggaagctGatggacaagcagaccttctg	9	9	11	12	0	1	2	0	1	1	1	3	4	3	4	3	2	3	3	3	2	2	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:22320755G>A	uc002dkk.2	+	6	444	c.288G>A	c.(286-288)CTG>CTA	p.L96L	POLR3E_uc002dkj.1_Silent_p.L96L|POLR3E_uc002dkm.2_Silent_p.L60L|POLR3E_uc010vbr.1_Silent_p.L96L|POLR3E_uc002dkl.2_Silent_p.L96L|POLR3E_uc010vbs.1_Silent_p.L60L|POLR3E_uc010vbt.1_Silent_p.L40L	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	96					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		CCAGGAAGCTGATGGACAAGC	0.617													39	291					0	0	0	0	A	22320755	A	A	22320755	2	1	161	1	0	0	0	0	0	0	0	1	12287	1277	45	2		2	POLR3E	16	22320755	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	6018098	22320755	68033998	152	29396											
HS3ST2	9956	broad.mit.edu	37	chr16	22926538	22926538	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccatccgcatcggcatgtaCgtgctgcacctggagagctg	7	8	13	13	3	0	1	0	0	0	1	2	2	1	1	3	2	4	6	3	2	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:22926538C>G	uc002dli.2	+	2	831	c.759C>G	c.(757-759)TAC>TAG	p.Y253*	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	253	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		TCGGCATGTACGTGCTGCACC	0.632													13	134					0	0	0	0	G	22926538	G	G	22926538	4	3	161	1	0	0	0	0	0	1	0	0	7403	547	19	3	765	3	HS3ST2	16	22926538	Nonsense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	605783	22926538	67428215	153	29397											
SRCAP	10847	broad.mit.edu	37	chr16	30723672	30723672	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggttaccatgtatgagaaGaagcttaatggcattcttgc	11	13	10	7	0	1	2	0	1	1	2	1	3	1	2	1	2	3	4	1	2	5	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:30723672G>A	uc002dze.1	+	13	2290	c.1905G>A	c.(1903-1905)AAG>AAA	p.K635K	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.K492K|SRCAP_uc010bzz.1_Silent_p.K205K	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	635	Helicase ATP-binding.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGTATGAGAAGAAGCTTAATG	0.532													11	95					0	0	0	0	A	30723672	A	A	30723672	2	1	161	1	0	0	0	0	0	0	0	1	15201	933	33	2		2	SRCAP	16	30723672	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	7797134	30723672	59631081	154	29398											
ORC6L	23594	broad.mit.edu	37	chr16	46726320	46726320	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaattaaactttctggtttGaacaaggagacatatcagag	15	13	8	5	0	2	3	1	1	1	2	2	4	2	3	0	2	2	1	0	2	6	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:46726320G>C	uc002eeh.2	+	3	282	c.222G>C	c.(220-222)TTG>TTC	p.L74F	ORC6L_uc002eeg.1_Missense_Mutation_p.L74F|ORC6L_uc010cbe.1_Missense_Mutation_p.L25F	NM_014321	NP_055136	Q9Y5N6	ORC6_HUMAN	origin recognition complex subunit 6	74					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA binding|protein binding				0		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TTTCTGGTTTGAACAAGGAGA	0.323													11	69					0	0	0	0	C	46726320	C	C	46726320	3	2	161	1	0	0	0	0	1	0	0	0	11320	1281	45	2	232	2	ORC6L	16	46726320	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	16002648	46726320	43628433	155	29399											
CPNE2	221184	broad.mit.edu	37	chr16	57157367	57157370	+	Frame_Shift_Del	DEL	CTGC	-	-																															cttgactacatcctgggaggCtgccagctcatgttcaccgt																										TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:57157367_57157370delCTGC	uc002eks.1	+	10	1138_1141	c.909_912delCTGC	c.(907-912)GGCTGCfs	p.G303fs	CPNE2_uc010cct.1_Frame_Shift_Del_p.G329fs|CPNE2_uc010ccu.1_Frame_Shift_Del_p.G303fs|CPNE2_uc002ekt.1_5'Flank	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	303_304										central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				TCCTGGGAGGCTGCCAGCTCATGT	0.426													---	---	---								-	57157370	-	-	57157367	7	5	161	1	0	1	0	1	0	0	0	0	3827	784	28	0	943	0	CPNE2	16	57157367	Frame_Shift_Del	DEL	CTGC	TCGA-CR-7395-01A-11D-2012-08	10431047	57157367	33197386	156	29400											
NOB1	28987	broad.mit.edu	37	chr16	69788590	69788590	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccttgtcccgaatctcagTgaccacctcccggatggtgt	6	10	11	14	2	1	1	1	1	1	0	4	3	3	2	5	3	0	0	5	3	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:69788590T>C	uc002exs.2	-	2	119	c.103A>G	c.(103-105)ACT>GCT	p.T35A		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	35	PINc.					nucleus	metal ion binding|protein binding				0						CGAATCTCAGTGACCACCTCC	0.632													5	36					0	0	0	0	C	69788590	C	C	69788590	3	2	161	1	0	0	0	0	1	0	0	0	10565	1696	59	5	1167	5	NOB1	16	69788590	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	12631223	69788590	20566163	157	29401											
PHLPP2	23035	broad.mit.edu	37	chr16	71683624	71683624	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccacaggacctgggagggtGagcccattcatttcacaagt	10	8	11	12	0	2	1	2	1	0	0	2	3	2	3	3	3	1	0	3	3	1	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:71683624G>A	uc002fax.2	-	18	3147	c.3141C>T	c.(3139-3141)CTC>CTT	p.L1047L	PHLPP2_uc002fav.2_Intron|PHLPP2_uc010cgf.2_Silent_p.L980L	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	1047						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						CTGGGAGGGTGAGCCCATTCA	0.512													19	153					0	0	0	0	A	71683624	A	A	71683624	2	1	161	1	0	0	0	0	0	0	0	1	11910	1277	45	2		2	PHLPP2	16	71683624	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	1895034	71683624	18671129	158	29402											
DHX38	9785	broad.mit.edu	37	chr16	72137934	72137934	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcctgctccgagagtccctCcgggaagccgacctggatca	8	7	11	15	3	1	1	1	0	0	1	5	5	5	3	6	2	2	1	6	2	1	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:72137934C>T	uc002fcb.2	+	14	2269	c.1914C>T	c.(1912-1914)CTC>CTT	p.L638L	DHX38_uc010vmp.1_Intron	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	638	Helicase ATP-binding.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				GAGAGTCCCTCCGGGAAGCCG	0.577													9	87					0	0	0	0	T	72137934	T	T	72137934	2	4	161	1	0	0	0	0	0	0	0	1	4533	842	30	2		2	DHX38	16	72137934	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	454310	72137934	18216819	159	29403											
PLCG2	5336	broad.mit.edu	37	chr16	81929467	81929467	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atctaccatggctggacgcgGactaccaagatcaagtttga	12	9	10	10	2	2	2	1	1	1	1	2	4	2	4	2	3	2	2	2	3	4	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr16:81929467G>A	uc002fgt.2	+	13	1280	c.1128G>A	c.(1126-1128)CGG>CGA	p.R376R	PLCG2_uc010chg.1_Silent_p.R376R	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	376	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						GCTGGACGCGGACTACCAAGA	0.557													16	96					0	0	0	0	A	81929467	A	A	81929467	2	1	161	1	0	0	0	0	0	0	0	1	12091	1161	41	2		2	PLCG2	16	81929467	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	9791533	81929467	8425286	160	29404											
C17orf85	55421	broad.mit.edu	37	chr17	3724646	3724646	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgggaatgatatcttcgcttCctgcaagaatgccaaaataa	14	10	8	9	2	1	2	0	1	1	1	3	3	2	3	2	1	2	2	2	1	7	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:3724646C>T	uc010ckl.1	-	9	920	c.897G>A	c.(895-897)TGG>TGA	p.W299*	C17orf85_uc002fwr.2_Nonsense_Mutation_p.W9*|C17orf85_uc002fwq.2_Nonsense_Mutation_p.W19*	NM_001114118	NP_001107590	Q53F19	CQ085_HUMAN	ELG protein isoform a	299							nucleotide binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		ATCTTCGCTTCCTGCAAGAAT	0.363													8	82					0	0	0	0	T	3724646	T	T	3724646	4	4	161	1	0	0	0	0	0	1	0	0	1896	869	30	2	985	2	C17orf85	17	3724646	Nonsense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08		3724646	77470564	161	29405											
KIAA0753	9851	broad.mit.edu	37	chr17	6483153	6483153	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagttcagcagccacagcacCcagagcttcatctaccagct	12	7	7	15	0	3	1	2	0	1	1	3	1	3	1	3	0	6	5	3	0	2	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:6483153C>G	uc002gde.3	-	19	3177	c.2818G>C	c.(2818-2820)GGT>CGT	p.G940R	KIAA0753_uc010vtd.1_Missense_Mutation_p.G396R|KIAA0753_uc010clo.2_Missense_Mutation_p.G641R|KIAA0753_uc010vte.1_Missense_Mutation_p.G641R	NM_014804	NP_055619	Q2KHM9	K0753_HUMAN	hypothetical protein LOC9851	940						centrosome					0				COAD - Colon adenocarcinoma(228;0.157)		GCCACAGCACCCAGAGCTTCA	0.378													10	95					0	0	0	0	G	6483153	G	G	6483153	3	3	161	1	0	0	0	0	1	0	0	0	8230	623	22	4	89	4	KIAA0753	17	6483153	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	2758507	6483153	74712057	162	29406											
DNAH2	146754	broad.mit.edu	37	chr17	7695575	7695575	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatgccctccttaggacacGgtatatgagtattttgtgga	10	13	10	8	1	0	1	0	1	0	0	1	3	1	3	2	3	1	2	2	3	4	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:7695575G>A	uc002giu.1	+	45	7073	c.7059G>A	c.(7057-7059)ACG>ACA	p.T2353T		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2353					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTTAGGACACGGTATATGAGT	0.532													10	98					0	0	0	0	A	7695575	A	A	7695575	2	1	161	1	0	0	0	0	0	0	0	1	4624	1103	39	1		1	DNAH2	17	7695575	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	1212422	7695575	73499635	163	29407											
NCOR1	9611	broad.mit.edu	37	chr17	16005052	16005052	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcattttcaggactgtcctcGctgggcttgacagcttcaac	7	12	10	12	1	2	1	2	1	0	0	4	2	3	2	1	2	2	4	1	2	1	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:16005052G>A	uc002gpo.2	-	20	2442	c.2202C>T	c.(2200-2202)AGC>AGT	p.S734S	NCOR1_uc002gpn.2_Silent_p.S750S|NCOR1_uc002gpp.1_Silent_p.S641S|NCOR1_uc002gpr.2_Silent_p.S641S	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	734					cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GACTGTCCTCGCTGGGCTTGA	0.463													13	67					0	0	0	0	A	16005052	A	A	16005052	2	1	161	1	0	0	0	0	0	0	0	1	10289	1078	38	1		1	NCOR1	17	16005052	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	8309477	16005052	65190158	164	29408											
FAM83G	644815	broad.mit.edu	37	chr17	18874772	18874772	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctttaggtgcttcgactgaGacagtttggagtatgggatt	8	14	13	6	1	0	1	0	1	0	1	1	5	0	3	1	3	1	3	1	3	2	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:18874772G>A	uc002guw.2	-	6	2539	c.2372C>T	c.(2371-2373)TCT>TTT	p.S791F	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	791										ovary(1)|central_nervous_system(1)	2						CTTCGACTGAGACAGTTTGGA	0.632													24	153					0	0	0	0	A	18874772	A	A	18874772	3	1	161	1	0	0	0	0	1	0	0	0	5671	942	33	2	103	2	FAM83G	17	18874772	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	2869720	18874772	62320438	165	29409											
KIAA0100	9703	broad.mit.edu	37	chr17	26961608	26961608	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctaatccctcagggggaaaAgggctgcctggatcaagctc	10	8	12	11	0	3	0	2	0	1	0	5	2	4	2	2	4	2	2	2	4	4	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:26961608A>G	uc002hbu.2	-	16	3096	c.2997T>C	c.(2995-2997)CCT>CCC	p.P999P		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	999						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CAGGGGGAAAAGGGCTGCCTG	0.493													3	131					0	0	0	0	G	26961608	G	G	26961608	2	3	161	1	0	0	0	0	0	0	0	1	8193	59	3	5		5	KIAA0100	17	26961608	Silent	SNP	A	TCGA-CR-7395-01A-11D-2012-08	8086836	26961608	54233602	166	29410											
KRT27	342574	broad.mit.edu	37	chr17	38933275	38933275	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagacaccctctgttcattCttgttgttgactttggtgga	7	16	10	8	0	3	2	1	1	2	1	3	4	3	3	1	2	0	3	1	2	1	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:38933275C>G	uc002hvg.2	-	8	1397	c.1356G>C	c.(1354-1356)AAG>AAC	p.K452N		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	452	Tail.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				TCTGTTCATTCTTGTTGTTGA	0.433													14	55					0	0	0	0	G	38933275	G	G	38933275	3	3	161	1	0	0	0	0	1	0	0	0	8503	912	32	2	27	2	KRT27	17	38933275	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	11971667	38933275	42261935	167	29411											
AKAP1	8165	broad.mit.edu	37	chr17	55183032	55183032	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgtcccaaagtagtgtcCacaccccccagtgtcacaga	10	8	8	15	0	2	1	1	0	1	1	4	1	4	1	5	0	0	1	5	0	2	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:55183032C>T	uc002iux.2	+	2	438	c.207C>T	c.(205-207)TCC>TCT	p.S69S	AKAP1_uc010wnl.1_Silent_p.S69S|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Silent_p.S69S	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	69					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					AAGTAGTGTCCACACCCCCCA	0.602													10	45					0	0	0	0	T	55183032	T	T	55183032	2	4	161	1	0	0	0	0	0	0	0	1	445	581	21	4		4	AKAP1	17	55183032	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	16249757	55183032	26012178	168	29412											
AXIN2	8313	broad.mit.edu	37	chr17	63533163	63533163	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcccattgcgtttgggcaaGgtactgcctctgctgccgct	4	13	11	13	2	1	0	0	0	1	0	2	0	2	0	3	2	5	5	3	2	2	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:63533163G>A	uc002jfi.2	-	7	2020	c.1731C>T	c.(1729-1731)ACC>ACT	p.T577T	AXIN2_uc002jfh.2_Intron	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	577				Missing (in Ref. 2; AAF22799).	cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						GTTTGGGCAAGGTACTGCCTC	0.652									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				5	19					0	0	0	0	A	63533163	A	A	63533163	2	1	161	1	0	0	0	0	0	0	0	1	1239	987	35	4		4	AXIN2	17	63533163	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	8350131	63533163	17662047	169	29413											
GALR2	8811	broad.mit.edu	37	chr17	74071008	74071008	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgggaacgcgagccaggCgggcggcgggggaggctggc	5	1	24	11	6	0	0	0	0	0	0	0	3	0	2	2	9	2	1	2	9	1	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:74071008C>T	uc002jqm.1	+	1	125	c.44C>T	c.(43-45)GCG>GTG	p.A15V	SRP68_uc010wsu.1_5'Flank|SRP68_uc002jqk.1_5'Flank|SRP68_uc002jql.1_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	15	Extracellular (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						GCGAGCCAGGCGGGCGGCGGG	0.741													3	7					0	0	0	0	T	74071008	T	T	74071008	3	4	161	1	0	0	0	0	1	0	0	0	6263	768	27	1	46	1	GALR2	17	74071008	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	10537845	74071008	7124202	170	29414											
DNAH17	8632	broad.mit.edu	37	chr17	76539977	76539977	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcactccagcatccctgaCtgctgcgtagcgcttgttga	6	12	9	14	2	1	2	1	2	0	0	3	2	3	2	2	0	4	5	2	0	1	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:76539977C>T	uc002jvv.1	-	13	1706	c.1600G>A	c.(1600-1602)GTC>ATC	p.V534I						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCATCCCTGACTGCTGCGTAG	0.498													28	196					0	0	0	0	T	76539977	T	T	76539977	3	4	161	1	0	0	0	0	1	0	0	0	4623	565	20	4	11154	4	DNAH17	17	76539977	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	2468969	76539977	4655233	171	29415											
CCDC40	55036	broad.mit.edu	37	chr17	78023899	78023899	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agagccgagcccagcggcagGagctgggggtgaatctctat	9	6	16	10	2	1	2	0	1	1	1	2	4	1	3	2	4	4	2	2	4	2	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:78023899G>A	uc010dht.2	+	7	1003	c.976G>A	c.(976-978)GAG>AAG	p.E326K	CCDC40_uc010wub.1_Missense_Mutation_p.E326K|CCDC40_uc002jxm.3_Missense_Mutation_p.E109K	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	326					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CCAGCGGCAGGAGCTGGGGGT	0.622													5	36					0	0	0	0	A	78023899	A	A	78023899	3	1	161	1	0	0	0	0	1	0	0	0	2825	1175	41	2	1002	2	CCDC40	17	78023899	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	1483922	78023899	3171311	172	29416											
SLC38A10	124565	broad.mit.edu	37	chr17	79226904	79226904	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatcgagctgtgcctcctcCggtgcctccttgccatcttc	3	12	9	17	3	1	0	0	0	1	0	6	2	4	0	6	1	4	1	6	1	0	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr17:79226904C>T	uc002jzz.1	-	12	1800	c.1425G>A	c.(1423-1425)CCG>CCA	p.P475P	SLC38A10_uc002jzy.1_Silent_p.P393P|SLC38A10_uc002kab.2_Silent_p.P475P	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	475					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GTGCCTCCTCCGGTGCCTCCT	0.682											OREG0024813	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	118					0	0	0	0	T	79226904	T	T	79226904	2	4	161	1	0	0	0	0	0	0	0	1	14666	639	23	1		1	SLC38A10	17	79226904	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	1203005	79226904	1968306	173	29417											
CETN1	1068	broad.mit.edu	37	chr18	580651	580651	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggtggacagggaaggcacGgggaagatcagcttcaatga	13	5	17	6	1	2	2	2	1	0	1	2	6	2	5	0	6	1	2	0	6	3	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr18:580651G>T	uc002kko.1	+	1	285	c.243G>T	c.(241-243)ACG>ACT	p.T81T		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	81	EF-hand 2.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2						GGGAAGGCACGGGGAAGATCA	0.537													5	52					3.59834e-05	7.14826e-05	1	0	T	580651	T	T	580651	2	4	161	1	0	0	0	0	0	0	0	1	3289	1103	39	3		3	CETN1	18	580651	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08		580651	77496597	174	29418											
KCTD1	284252	broad.mit.edu	37	chr18	24081097	24081097	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtacatgtggccgcccacatCaatgtggacaggcgcattgg	9	8	13	11	2	1	0	1	0	0	0	1	1	1	1	2	4	1	2	2	4	2	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr18:24081097C>G	uc002kvw.2	-	2	663	c.103G>C	c.(103-105)GAT>CAT	p.D35H	KCTD1_uc010xbj.1_Missense_Mutation_p.D643H|KCTD1_uc010xbk.1_Missense_Mutation_p.D35H	NM_001136205	NP_001129677	Q719H9	KCTD1_HUMAN	potassium channel tetramerisation domain	35	BTB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			ovary(1)	1	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			CCGCCCACATCAATGTGGACA	0.507													6	109					0	0	0	0	G	24081097	G	G	24081097	3	3	161	1	0	0	0	0	1	0	0	0	8135	826	29	2	686	2	KCTD1	18	24081097	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	23500446	24081097	53996151	175	29419											
DSG1	1828	broad.mit.edu	37	chr18	28914090	28914090	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggcagtaattttctttatCtctggaaatgaaggaaattg	13	15	9	4	0	2	1	0	1	2	0	3	3	2	3	0	3	0	2	0	3	5	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr18:28914090C>G	uc002kwp.2	+	8	1142	c.930C>G	c.(928-930)ATC>ATG	p.I310M		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	310	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TTTTCTTTATCTCTGGAAATG	0.294													9	71					0	0	0	0	G	28914090	G	G	28914090	3	3	161	1	0	0	0	0	1	0	0	0	4798	903	32	2	960	2	DSG1	18	28914090	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	4832993	28914090	49163158	176	29420											
CDH20	28316	broad.mit.edu	37	chr18	59221475	59221475	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccggaaacaaccatacatCatcgacgacgaggaaaacat	18	4	7	12	4	1	0	1	0	0	0	2	5	1	2	2	2	4	0	2	2	5	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr18:59221475C>A	uc010dps.1	+	11	1965	c.1953C>A	c.(1951-1953)ATC>ATA	p.I651I	CDH20_uc002lif.2_Silent_p.I645I	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	651	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				AACCATACATCATCGACGACG	0.567													12	110					9.05144e-12	1.85638e-11	1	0	A	59221475	A	A	59221475	2	1	161	1	0	0	0	0	0	0	0	1	3121	816	29	2		2	CDH20	18	59221475	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	30307385	59221475	18855773	177	29421											
AP3D1	8943	broad.mit.edu	37	chr19	2121736	2121736	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggacagagggcacgcaccatCccatagagcaggtccagggc	11	3	14	13	1	0	2	0	0	0	2	2	3	2	3	3	4	1	3	3	4	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr19:2121736C>T	uc002luz.2	-	12	1321	c.1098G>A	c.(1096-1098)GGG>GGA	p.G366G	AP3D1_uc002luy.2_Silent_p.G275G|AP3D1_uc002lva.2_Silent_p.G366G	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	366	HEAT 7.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGCACCATCCCATAGAGCA	0.637													8	57					0	0	0	0	T	2121736	T	T	2121736	2	4	161	1	0	0	0	0	0	0	0	1	746	842	30	2		2	AP3D1	19	2121736	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08		2121736	57007247	178	29422											
ZNF440	126070	broad.mit.edu	37	chr19	11943309	11943309	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagatatgtgaataaccttCaaagtcatgaaaggacacaa	18	9	7	7	0	3	3	3	2	0	1	3	4	3	4	1	1	1	0	1	1	6	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr19:11943309C>T	uc002msp.1	+	4	1474	c.1318C>T	c.(1318-1320)CAA>TAA	p.Q440*		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	440	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAATAACCTTCAAAGTCATGA	0.398													8	51					0	0	0	0	T	11943309	T	T	11943309	4	4	161	1	0	0	0	0	0	1	0	0	17980	827	29	2	1332	2	ZNF440	19	11943309	Nonsense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	9821573	11943309	47185674	179	29423											
IL27RA	9466	broad.mit.edu	37	chr19	14161619	14161619	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaccttccttggggtccCtgtgagctgtgggtgacagc	4	11	14	12	0	0	3	0	3	0	0	2	3	2	3	4	3	2	1	4	3	0	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr19:14161619C>A	uc002mxx.2	+	11	1875	c.1452C>A	c.(1450-1452)CCC>CCA	p.P484P		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	484	Extracellular (Potential).|Fibronectin type-III 3.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						CTTGGGGTCCCTGTGAGCTGT	0.552													4	33					0.000602214	0.00119099	1	0	A	14161619	A	A	14161619	2	1	161	1	0	0	0	0	0	0	0	1	7720	668	24	4		4	IL27RA	19	14161619	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	2218310	14161619	44967364	180	29424											
OR10H4	126541	broad.mit.edu	37	chr19	16060277	16060277	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtacctgggctggtggcTcagtcatggggatgatggtg	5	11	17	8	0	2	1	2	1	0	0	2	2	2	2	2	6	1	3	2	6	1	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr19:16060277T>G	uc010xov.1	+	1	460	c.460T>G	c.(460-462)TCA>GCA	p.S154A		NM_001004465	NP_001004465	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GGCTGGTGGCTCAGTCATGGG	0.512													20	112					0	0	0	0	G	16060277	G	G	16060277	3	3	161	1	0	0	0	0	1	0	0	0	10962	1551	54	5	462	5	OR10H4	19	16060277	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	1898658	16060277	43068706	181	29425											
ZNF585B	92285	broad.mit.edu	37	chr19	37677063	37677063	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggcttttctcctgtgtgaAttcgtttatgaacatggagt	8	16	11	6	1	1	2	0	2	1	0	3	3	1	3	1	2	1	2	1	2	3	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr19:37677063A>C	uc002ofq.2	-	5	1630	c.1376T>G	c.(1375-1377)ATT>AGT	p.I459S	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.I273S	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	459	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCCTGTGTGAATTCGTTTATG	0.373													13	119					0	0	0	0	C	37677063	C	C	37677063	3	2	161	1	0	0	0	0	1	0	0	0	18085	101	4	5	937	5	ZNF585B	19	37677063	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08	21616786	37677063	21451920	182	29426											
LRFN1	57622	broad.mit.edu	37	chr19	39798886	39798886	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctggagcccttgacgcggCggctgtccccgtcgccatac	5	7	12	17	5	0	1	0	1	0	0	2	2	1	2	5	3	2	1	5	3	1	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr19:39798886C>T	uc002okw.2	-	2	1703	c.1703G>A	c.(1702-1704)CGC>CAC	p.R568H		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	568	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CTTGACGCGGCGGCTGTCCCC	0.682													6	34					0	0	0	0	T	39798886	T	T	39798886	3	4	161	1	0	0	0	0	1	0	0	0	8987	768	27	1	616	1	LRFN1	19	39798886	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	2121823	39798886	19330097	183	29427											
SIGLEC12	89858	broad.mit.edu	37	chr19	52001378	52001378	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttcacatgcactcgaggCagctccagcaccccaaggtt	9	8	8	16	1	1	0	1	0	0	0	4	1	3	0	4	2	3	5	4	2	1	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr19:52001378C>A	uc002pwx.1	-	5	1355	c.1299G>T	c.(1297-1299)CTG>CTT	p.L433L	SIGLEC12_uc002pww.1_Silent_p.L315L|SIGLEC12_uc010eoy.1_Silent_p.L160L	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	433	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GCACTCGAGGCAGCTCCAGCA	0.607													10	56					1.76689e-08	3.57413e-08	1	0	A	52001378	A	A	52001378	2	1	161	1	0	0	0	0	0	0	0	1	14373	697	25	4		4	SIGLEC12	19	52001378	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	12202492	52001378	7127605	184	29428											
ISM1	140862	broad.mit.edu	37	chr20	13280034	13280034	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggcccggcctcccaacaaCggacagaagtgcacagagag	13	2	13	13	2	0	2	0	0	0	2	1	5	1	3	3	3	3	1	3	3	3	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr20:13280034C>T	uc010gce.1	+	6	1329	c.1323C>T	c.(1321-1323)AAC>AAT	p.N441N	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	441	AMOP.					extracellular region					0						CTCCCAACAACGGACAGAAGT	0.577													10	52					0	0	0	0	T	13280034	T	T	13280034	2	4	161	1	0	0	0	0	0	0	0	1	7899	535	19	1		1	ISM1	20	13280034	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08		13280034	49745486	185	29429											
CHAF1B	8208	broad.mit.edu	37	chr21	37788639	37788639	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagactcgatgaaaacaaagGaggcacggaaagtctggacc	16	4	12	9	2	1	2	0	1	1	1	2	6	1	5	1	4	1	1	1	4	4	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr21:37788639G>A	uc002yvj.2	+	14	1793	c.1655G>A	c.(1654-1656)GGA>GAA	p.G552E		NM_005441	NP_005432	Q13112	CAF1B_HUMAN	chromatin assembly factor 1 subunit B	552					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			ovary(1)|skin(1)	2						GAAAACAAAGGAGGCACGGAA	0.567													4	35					0	0	0	0	A	37788639	A	A	37788639	3	1	161	1	0	0	0	0	1	0	0	0	3327	1174	41	2	1705	2	CHAF1B	21	37788639	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08		37788639	10341256	186	29430											
SLC37A1	54020	broad.mit.edu	37	chr21	43974187	43974187	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagcactcaaaaggctatGagaatggtacaaacagattg	17	7	9	8	0	1	2	1	1	0	2	1	3	1	2	1	2	3	3	1	2	6	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr21:43974187G>A	uc002zbi.2	+	11	1196	c.784G>A	c.(784-786)GAG>AAG	p.E262K	SLC37A1_uc002zbj.2_Missense_Mutation_p.E262K	NM_018964	NP_061837	P57057	GLPT_HUMAN	solute carrier family 37 member 1	262					carbohydrate transport|transmembrane transport	integral to membrane					0						AAAAGGCTATGAGAATGGTAC	0.388													4	20					0	0	0	0	A	43974187	A	A	43974187	3	1	161	1	0	0	0	0	1	0	0	0	14661	1291	45	2	818	2	SLC37A1	21	43974187	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	6185548	43974187	4155708	187	29431											
KRTAP10-2	386679	broad.mit.edu	37	chr21	45970921	45970921	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgcagcagacaggcacacGgcaggactgctggcaggagg	10	5	16	10	1	0	1	0	0	0	1	0	3	0	3	0	6	3	6	0	6	0	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr21:45970921G>C	uc002zfi.1	-	1	468	c.421C>G	c.(421-423)CGT>GGT	p.R141G	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198693	NP_941966	P60368	KR102_HUMAN	keratin associated protein 10-2	141	22 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)	1						ACAGGCACACGGCAGGACTGC	0.617													26	154					0	0	0	0	C	45970921	C	C	45970921	3	2	161	1	0	0	0	0	1	0	0	0	8548	1116	39	3	350	3	KRTAP10-2	21	45970921	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	1996734	45970921	2158974	188	29432											
PCBP3	54039	broad.mit.edu	37	chr21	47360032	47360032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcaaaatcgccaacgccaCggaagggtcctcagagcgtc	12	5	11	13	4	2	1	2	0	0	1	5	3	3	2	3	2	2	0	3	2	4	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr21:47360032C>T	uc002zhq.1	+	13	1123	c.998C>T	c.(997-999)ACG>ATG	p.T333M	PCBP3_uc002zhp.1_Missense_Mutation_p.T313M|PCBP3_uc002zhs.1_Missense_Mutation_p.T307M|PCBP3_uc002zhr.1_Missense_Mutation_p.T332M|PCBP3_uc002zht.1_Missense_Mutation_p.T323M	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	333	KH 3.				mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		GCCAACGCCACGGAAGGGTCC	0.527													5	64					0	0	0	0	T	47360032	T	T	47360032	3	4	161	1	0	0	0	0	1	0	0	0	11556	536	19	1	1048	1	PCBP3	21	47360032	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	1389111	47360032	769863	189	29433											
OSBP2	23762	broad.mit.edu	37	chr22	31285493	31285493	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaggtactagatggtgcctCgctcgtgcccaagggttcat	7	10	13	11	2	1	1	1	0	0	1	3	1	1	1	2	3	3	4	2	3	3	3			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr22:31285493C>T	uc003aiy.1	+	7	1597	c.1493C>T	c.(1492-1494)TCG>TTG	p.S498L	OSBP2_uc011ala.1_Missense_Mutation_p.S332L|OSBP2_uc010gwc.1_Missense_Mutation_p.S325L|OSBP2_uc011alb.1_Intron|OSBP2_uc003aiz.1_Missense_Mutation_p.S497L|OSBP2_uc003aja.1_Missense_Mutation_p.S131L|OSBP2_uc011alc.1_Missense_Mutation_p.S240L|OSBP2_uc003ajb.2_Missense_Mutation_p.S43L|OSBP2_uc011ald.1_Missense_Mutation_p.S42L|OSBP2_uc010gwd.1_Missense_Mutation_p.S43L	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	498					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						GATGGTGCCTCGCTCGTGCCC	0.577													18	178					0	0	0	0	T	31285493	T	T	31285493	3	4	161	1	0	0	0	0	1	0	0	0	11328	893	31	1	1519	1	OSBP2	22	31285493	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08		31285493	20019073	190	29434											
EP300	2033	broad.mit.edu	37	chr22	41572250	41572250	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagagactgtctgtttttcaGgtcttctttgtgatccgcct	6	17	9	9	1	4	2	1	1	3	1	5	3	5	2	2	1	0	1	2	1	1	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr22:41572250G>A	uc003azl.3	+	30	5175	c.4780_splice	c.e30-1	p.V1594_splice		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300						apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CTGTTTTTCAGGTCTTCTTTG	0.318			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				10	174					0	0	0	0	A	41572250	A	A	41572250	5	1	161	1	0	0	0	0	0	0	1	0	5172	1014	35	4	4897	4	EP300	22	41572250	Splice_Site	SNP	G	TCGA-CR-7395-01A-11D-2012-08	10286757	41572250	9732316	191	29435											
PNPLA3	80339	broad.mit.edu	37	chr22	44340652	44340652	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtgttcactcgagtgctGatgtgtctgctccccgcctc	4	12	11	14	2	2	1	1	1	1	0	5	2	3	1	3	1	2	3	3	1	0	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chr22:44340652G>A	uc003bei.1	+	8	1367	c.1194G>A	c.(1192-1194)CTG>CTA	p.L398L	PNPLA3_uc010gzm.1_RNA	NM_025225	NP_079501	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	398	Lumenal (Potential).				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)				CTCGAGTGCTGATGTGTCTGC	0.562													15	85					0	0	0	0	A	44340652	A	A	44340652	2	1	161	1	0	0	0	0	0	0	0	1	12221	1277	45	2		2	PNPLA3	22	44340652	Silent	SNP	G	TCGA-CR-7395-01A-11D-2012-08	2768402	44340652	6963914	192	29436											
SFRS17A	8227	broad.mit.edu	37	chrX	1720159	1720159	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgggagcccagcaagggccGgggccgggccaccggagacg	7	0	19	15	5	0	1	0	0	0	1	0	3	0	2	6	6	2	1	6	6	1	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:1720159G>A	uc004cqa.2	+	5	1956	c.1760G>A	c.(1759-1761)CGG>CAG	p.R587Q	SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_Intron	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	587	Arg-rich.				B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGCAAGGGCCGGGGCCGGGCC	0.687													4	33					0	0	0	0	A	1720159	A	A	1720159	3	1	161	1	0	0	0	0	1	0	0	0	14238	1116	39	1	1774	1	SFRS17A	23	1720159	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08		1720159	153550401	193	29437											
USP9X	8239	broad.mit.edu	37	chrX	41048594	41048594	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgagccagacttggaagaCgaacaggtttgctgtgaagc	13	8	13	7	1	0	4	0	2	0	2	0	6	0	5	1	2	4	2	1	2	4	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:41048594C>T	uc004dfb.2	+	26	4476	c.3843C>T	c.(3841-3843)GAC>GAT	p.D1281D	USP9X_uc004dfc.2_Silent_p.D1281D	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1281					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						ACTTGGAAGACGAACAGGTTT	0.388													9	72					0	0	0	0	T	41048594	T	T	41048594	2	4	161	1	0	0	0	0	0	0	0	1	17158	535	19	1		1	USP9X	23	41048594	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	39328435	41048594	114221966	194	29438											
WDR13	64743	broad.mit.edu	37	chrX	48458093	48458093	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatgtttttgaccagcacGtggatgaggcaggtgagcca	10	10	13	8	1	1	3	1	3	0	0	1	4	1	4	2	3	2	3	2	3	0	2			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:48458093G>A	uc004dkh.1	+	5	658	c.511G>A	c.(511-513)GTG>ATG	p.V171M	WDR13_uc010nif.1_Missense_Mutation_p.V49M|WDR13_uc004dki.1_Missense_Mutation_p.V79M|WDR13_uc004dkj.1_Missense_Mutation_p.V171M|WDR13_uc004dkk.1_Missense_Mutation_p.V79M|WDR13_uc004dkl.3_Missense_Mutation_p.V79M|WDR13_uc011mme.1_Missense_Mutation_p.V49M	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	171	WD 1.					cytoplasm|nucleus				ovary(2)	2						TGACCAGCACGTGGATGAGGC	0.572													11	80					0	0	0	0	A	48458093	A	A	48458093	3	1	161	1	0	0	0	0	1	0	0	0	17343	1145	40	1	525	1	WDR13	23	48458093	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	7409499	48458093	106812467	195	29439											
MTMR8	55613	broad.mit.edu	37	chrX	63551561	63551561	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcacagggaaactgttccaTtaattgccagatacagtcta	13	10	9	9	0	1	1	0	0	1	1	2	2	2	2	2	2	3	2	2	2	4	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:63551561T>A	uc004dvs.2	-	11	1296	c.1228A>T	c.(1228-1230)ATG>TTG	p.M410L	MTMR8_uc011mou.1_Intron|MTMR8_uc004dvt.1_Missense_Mutation_p.M410L	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	410	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						AACTGTTCCATTAATTGCCAG	0.438													4	39					0	0	0	0	A	63551561	A	A	63551561	3	1	161	1	0	0	0	0	1	0	0	0	10002	1493	52	5	902	5	MTMR8	23	63551561	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	15093468	63551561	91718999	196	29440											
TAF1	6872	broad.mit.edu	37	chrX	70607298	70607298	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagggccaatacgcatattcGagactttctacaggtaagaa	15	9	9	8	2	1	2	0	0	1	2	2	3	1	2	1	2	2	2	1	2	7	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:70607298G>A	uc004dzu.3	+	15	2462	c.2411G>A	c.(2410-2412)CGA>CAA	p.R804Q	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.R825Q|TAF1_uc004dzv.3_5'Flank	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	804					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				ACGCATATTCGAGACTTTCTA	0.378													8	69					0	0	0	0	A	70607298	A	A	70607298	3	1	161	1	0	0	0	0	1	0	0	0	15579	1058	37	1	2532	1	TAF1	23	70607298	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	7055737	70607298	84663262	197	29441											
NOX1	27035	broad.mit.edu	37	chrX	100098950	100098950	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attcctataactcaaaaattTtctttgttgaagtagaattg	14	17	5	5	0	2	2	1	1	1	1	3	2	3	2	1	0	1	2	1	0	7	9			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:100098950T>G	uc004egj.2	-	13	1892	c.1686A>C	c.(1684-1686)GAA>GAC	p.E562D	NOX1_uc004egl.3_Missense_Mutation_p.E513D|NOX1_uc010nne.2_Missense_Mutation_p.E525D	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	562	Cytoplasmic (Potential).				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						CTCAAAAATTTTCTTTGTTGA	0.408													3	32					0	0	0	0	G	100098950	G	G	100098950	3	3	161	1	0	0	0	0	1	0	0	0	10610	1838	64	5	12	5	NOX1	23	100098950	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	29491652	100098950	55171610	198	29442											
BTK	695	broad.mit.edu	37	chrX	100608293	100608293	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctcactgttagtaaatctCtcatatggcatcttccccag	9	14	6	12	0	4	0	2	0	3	0	7	0	5	0	2	1	0	3	2	1	4	4			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:100608293C>G	uc004ehg.2	-	18	1990	c.1797G>C	c.(1795-1797)GAG>GAC	p.E599D	BTK_uc004ehf.2_Missense_Mutation_p.E99D|BTK_uc010nnh.2_RNA|BTK_uc010nni.2_Intron|BTK_uc004ehe.2_RNA|BTK_uc010nnj.2_RNA|BTK_uc010nnk.2_RNA|BTK_uc010nnl.2_Missense_Mutation_p.E75D|BTK_uc010nnm.2_Missense_Mutation_p.E169D|BTK_uc010nnn.2_Missense_Mutation_p.E423D|BTK_uc010nno.2_Missense_Mutation_p.E633D	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	599	Protein kinase.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TAGTAAATCTCTCATATGGCA	0.423									Agammaglobulinemia_X-linked				18	160					0	0	0	0	G	100608293	G	G	100608293	3	3	161	1	0	0	0	0	1	0	0	0	1562	912	32	2	190	2	BTK	23	100608293	Missense_Mutation	SNP	C	TCGA-CR-7395-01A-11D-2012-08	509343	100608293	54662267	199	29443											
ATP1B4	23439	broad.mit.edu	37	chrX	119504589	119504591	+	In_Frame_Del	DEL	CTT	-	-																															ggcctgatcttactcatttaCttcttcttctatgcctcctt																										TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:119504589_119504591delCTT	uc004esr.2	+	3	432_434	c.348_350delCTT	c.(346-351)TACTTC>TAC	p.F119del	ATP1B4_uc004esq.2_In_Frame_Del_p.F115del|ATP1B4_uc011mtx.1_In_Frame_Del_p.F84del|ATP1B4_uc011mty.1_Intron	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	119	Helical; Signal-anchor for type II membrane protein; (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						TACTCATTTACTTCTTCTTCTAT	0.483													---	---	---								-	119504591	-	-	119504589	7	5	161	1	0	1	0	1	0	0	0	0	1137	576	20	0	358	0	ATP1B4	23	119504589	In_Frame_Del	DEL	CTT	TCGA-CR-7395-01A-11D-2012-08	18896296	119504589	35765971	200	29444											
STAG2	10735	broad.mit.edu	37	chrX	123159747	123159747	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaagatatcgaaggaaaaaaCcaaaagcaaggcaaaggcaa	23	2	10	6	1	0	1	0	0	0	1	1	4	0	2	1	3	2	3	1	3	11	1			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:123159747C>T	uc004etz.3	+	3	441	c.102C>T	c.(100-102)AAC>AAT	p.N34N	STAG2_uc004eua.2_Silent_p.N34N|STAG2_uc004eub.2_Silent_p.N34N|STAG2_uc004euc.2_Silent_p.N34N|STAG2_uc004eud.2_Silent_p.N34N|STAG2_uc004eue.2_Silent_p.N34N	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	34					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						AAGGAAAAAACCAAAAGCAAG	0.323													7	110					0	0	0	0	T	123159747	T	T	123159747	2	4	161	1	0	0	0	0	0	0	0	1	15309	506	18	4		4	STAG2	23	123159747	Silent	SNP	C	TCGA-CR-7395-01A-11D-2012-08	3655158	123159747	32110813	201	29445											
DDX26B	203522	broad.mit.edu	37	chrX	134690127	134690127	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtggaaagtacaatgaacTtggatatccatttggttatt	13	14	9	5	0	0	1	0	1	0	0	1	3	1	3	1	3	2	2	1	3	6	6			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:134690127T>G	uc004eyw.3	+	9	1457	c.1094T>G	c.(1093-1095)CTT>CGT	p.L365R		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	365											0	Acute lymphoblastic leukemia(192;6.56e-05)					TACAATGAACTTGGATATCCA	0.348													7	95					0	0	0	0	G	134690127	G	G	134690127	3	3	161	1	0	0	0	0	1	0	0	0	4370	1609	56	5	1128	5	DDX26B	23	134690127	Missense_Mutation	SNP	T	TCGA-CR-7395-01A-11D-2012-08	11530380	134690127	20580433	202	29446											
PLXNA3	55558	broad.mit.edu	37	chrX	153696341	153696341	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgtggccctggagtgcaagGaaggtgcctgaggcggggcg	6	6	21	8	2	0	1	0	1	0	0	0	3	0	3	2	7	2	1	2	7	2	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:153696341G>A	uc004flm.2	+	21	3990	c.3817G>A	c.(3817-3819)GAA>AAA	p.E1273K		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1273	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGAGTGCAAGGAAGGTGCCTG	0.642													13	55					0	0	0	0	A	153696341	A	A	153696341	3	1	161	1	0	0	0	0	1	0	0	0	12176	1175	41	2	3895	2	PLXNA3	23	153696341	Missense_Mutation	SNP	G	TCGA-CR-7395-01A-11D-2012-08	19006214	153696341	1574219	203	29447											
PLXNA3	55558	broad.mit.edu	37	chrX	153696645	153696645	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagacctcctgctccccacaGacgccacccaacgtggagaa	11	4	9	17	2	0	3	0	0	0	3	2	5	2	3	6	1	2	1	6	1	2	0			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:153696645G>A	uc004flm.2	+	23	4137	c.3964_splice	c.e23-1	p.T1322_splice		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor						axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTCCCCACAGACGCCACCCA	0.672													7	76					0	0	0	0	A	153696645	A	A	153696645	5	1	161	1	0	0	0	0	0	0	1	0	12176	956	33	2	4049	2	PLXNA3	23	153696645	Splice_Site	SNP	G	TCGA-CR-7395-01A-11D-2012-08	304	153696645	1573915	204	29448											
MPP1	4354	broad.mit.edu	37	chrX	154019310	154019310	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcacatttgtgccattgAtttctaggatctcatccccc	7	16	6	12	0	3	1	2	1	2	0	5	2	4	2	3	1	1	0	3	1	1	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:154019310A>C	uc004fmp.1	-	4	474	c.359T>G	c.(358-360)ATC>AGC	p.I120S	MPP1_uc010nvg.1_Missense_Mutation_p.I120S|MPP1_uc011mzv.1_Missense_Mutation_p.I90S|MPP1_uc004fmq.1_Missense_Mutation_p.I74S|MPP1_uc011mzw.1_Missense_Mutation_p.I103S|MPP1_uc010nvh.1_Intron	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	120	PDZ.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGTGCCATTGATTTCTAGGAT	0.423													7	268					0	0	0	0	C	154019310	C	C	154019310	3	2	161	1	0	0	0	0	1	0	0	0	9786	333	12	5	1077	5	MPP1	23	154019310	Missense_Mutation	SNP	A	TCGA-CR-7395-01A-11D-2012-08	322665	154019310	1251250	205	29449											
F8	2157	broad.mit.edu	37	chrX	154128150	154128150	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattttctaaccttgatccaAgaaaagggctccttggtgct	10	13	8	10	0	1	2	0	1	1	1	3	2	3	2	3	2	2	2	3	2	4	5			TCGA-CR-7395-01A-11D-2012-08	TCGA-CR-7395-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bd0b1b16-ee20-48e5-be11-70eac9c15630	1ac40883-5a89-4e4a-bd59-25460b3aa7eb	g.chrX:154128150A>C	uc004fmt.2	-	21	6435	c.6264T>G	c.(6262-6264)TCT>TCG	p.S2088S	F8_uc010nvi.1_Intron	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	2088	F5/8 type C 1.		S -> F (in HEMA; severe).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CCTTGATCCAAGAAAAGGGCT	0.413													4	34					0	0	0	0	C	154128150	C	C	154128150	2	2	161	1	0	0	0	0	0	0	0	1	5375	59	3	5		5	F8	23	154128150	Silent	SNP	A	TCGA-CR-7395-01A-11D-2012-08	108840	154128150	1142410	206	29450											
MUTYH	4595	broad.mit.edu	37	chr1	45799087	45799087	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcctcgcctgcctacccGtcttctccatggtaggtccc	3	12	8	18	2	2	0	0	0	2	0	6	0	4	0	6	2	3	2	6	2	2	3			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:45799087G>A	uc001cnm.2	-	3	553	c.337C>T	c.(337-339)CGG>TGG	p.R113W	MUTYH_uc009vxn.2_Intron|MUTYH_uc001cnf.2_Missense_Mutation_p.R88W|MUTYH_uc009vxo.2_Missense_Mutation_p.R88W|MUTYH_uc001cng.2_Missense_Mutation_p.R99W|MUTYH_uc001cnj.2_Translation_Start_Site|MUTYH_uc001cni.2_Missense_Mutation_p.R88W|MUTYH_uc001cnh.2_Missense_Mutation_p.R89W|MUTYH_uc001cno.2_Translation_Start_Site|MUTYH_uc001cnk.2_Translation_Start_Site|MUTYH_uc010oll.1_Intron|MUTYH_uc001cnl.2_Missense_Mutation_p.R102W|MUTYH_uc009vxp.2_Missense_Mutation_p.R116W|MUTYH_uc001cnn.2_Missense_Mutation_p.R103W	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	113					depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					CTGCCTACCCGTCTTCTCCAT	0.582			Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				8	80					0	0	0	0	A	45799087	A	A	45799087	3	1	162	1	0	0	0	0	1	0	0	0	10046	1144	40	1	1359	1	MUTYH	1	45799087	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08		45799087	203451534	1	29451											
SGIP1	84251	broad.mit.edu	37	chr1	67195004	67195004	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcctgctggcatcaccagAcactttgccaacaacccgtc	9	10	6	16	1	1	1	1	0	0	1	3	1	2	1	4	1	4	2	4	1	2	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:67195004A>G	uc001dcr.2	+	20	2017	c.1800A>G	c.(1798-1800)AGA>AGG	p.R600R	SGIP1_uc010opd.1_Silent_p.R200R|SGIP1_uc001dcs.2_Silent_p.R200R|SGIP1_uc001dct.2_Silent_p.R202R|SGIP1_uc009wat.2_Silent_p.R394R|SGIP1_uc001dcu.2_Silent_p.R105R	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	600					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						GCATCACCAGACACTTTGCCA	0.468													7	86					0	0	0	0	G	67195004	G	G	67195004	2	3	162	1	0	0	0	0	0	0	0	1	14271	272	10	5		5	SGIP1	1	67195004	Silent	SNP	A	TCGA-CR-7397-01A-11D-2012-08	21395917	67195004	182055617	2	29452											
NBPF9	400818	broad.mit.edu	37	chr1	144618124	144618124	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctcaggaacgagagctgacGcagttaaaggagaagttaca	15	7	12	7	2	1	3	1	1	1	2	2	6	1	4	0	2	3	4	0	2	5	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:144618124G>T	uc009wig.1	+	6	397	c.321G>T	c.(319-321)ACG>ACT	p.T107T	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Silent_p.T38T|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Silent_p.T38T|NBPF9_uc010oyg.1_Silent_p.T72T|NBPF9_uc009wii.1_5'UTR	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	107	Potential.					cytoplasm					0						GAGAGCTGACGCAGTTAAAGG	0.493													5	409					1.96292e-10	2.5971e-10	1	0	T	144618124	T	T	144618124	2	4	162	1	0	0	0	0	0	0	0	1	10253	1074	38	3		3	NBPF9	1	144618124	Silent	SNP	G	TCGA-CR-7397-01A-11D-2012-08	77423120	144618124	104632497	3	29453											
NTRK1	4914	broad.mit.edu	37	chr1	156837972	156837972	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggaggaggagggactgggcGgagtgcctgaacagaagctg	10	4	21	6	1	0	2	0	1	0	1	0	7	0	7	1	6	3	1	1	6	2	0			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:156837972G>A	uc001fqh.1	+	5	561	c.505G>A	c.(505-507)GGA>AGA	p.G169R	NTRK1_uc001fqf.1_Missense_Mutation_p.G139R|NTRK1_uc009wsi.1_5'UTR|NTRK1_uc001fqi.1_Missense_Mutation_p.G169R|NTRK1_uc009wsk.1_Missense_Mutation_p.G169R	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	169	LRRCT.|Extracellular (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GGGACTGGGCGGAGTGCCTGA	0.657			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			7	64					0	0	0	0	A	156837972	A	A	156837972	3	1	162	1	0	0	0	0	1	0	0	0	10760	1117	39	1	653	1	NTRK1	1	156837972	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	12219848	156837972	92412649	4	29454											
GPR25	2848	broad.mit.edu	37	chr1	200842880	200842880	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccgcacgtgggtcgggccCggaggaactcgctgcgcatc	5	5	16	15	7	0	0	0	0	0	0	3	2	0	2	2	4	2	3	2	4	1	0			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:200842880C>T	uc001gvn.1	+	1	715	c.715C>T	c.(715-717)CGG>TGG	p.R239W		NM_005298	NP_005289	O00155	GPR25_HUMAN	G protein-coupled receptor 25	239	Cytoplasmic (Potential).					integral to plasma membrane				ovary(1)	1						GGGTCGGGCCCGGAGGAACTC	0.692													5	58					0	0	0	0	T	200842880	T	T	200842880	3	4	162	1	0	0	0	0	1	0	0	0	6721	643	23	1	717	1	GPR25	1	200842880	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08	44004908	200842880	48407741	5	29455											
ZNF238	10472	broad.mit.edu	37	chr1	244218372	244218372	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagactttctcttgcatgtaCaccctcaagcgccacgagag	11	9	8	13	2	2	2	1	0	1	2	3	3	2	2	2	0	3	2	2	0	3	3			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:244218372C>T	uc001iae.2	+	1	1791	c.1269C>T	c.(1267-1269)TAC>TAT	p.Y423Y	ZNF238_uc001iad.3_Silent_p.Y432Y|ZNF238_uc001iaf.1_3'UTR	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	423	C2H2-type 2.|Interaction with DNMT3A.				negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			CTTGCATGTACACCCTCAAGC	0.627													7	76					0	0	0	0	T	244218372	T	T	244218372	2	4	162	1	0	0	0	0	0	0	0	1	17857	489	17	4		4	ZNF238	1	244218372	Silent	SNP	C	TCGA-CR-7397-01A-11D-2012-08	43375492	244218372	5032249	6	29456											
OR2L13	284521	broad.mit.edu	37	chr1	248263541	248263541	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatgctcaatcccattatCtacagcctgaggaataagga	13	9	7	12	0	2	1	1	1	1	0	3	3	3	3	3	2	3	1	3	2	5	3			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr1:248263541C>A	uc001ids.2	+	3	1201	c.864C>A	c.(862-864)ATC>ATA	p.I288I		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ATCCCATTATCTACAGCCTGA	0.493													8	59					0.00448238	0.00566889	1	0	A	248263541	A	A	248263541	2	1	162	1	0	0	0	0	0	0	0	1	11060	903	32	2		2	OR2L13	1	248263541	Silent	SNP	C	TCGA-CR-7397-01A-11D-2012-08	4045169	248263541	987080	7	29457											
NCK2	8440	broad.mit.edu	37	chr2	106497876	106497876	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgccaatggcagcggcgccGaccgcatctacgacctcaac	9	4	10	18	6	2	0	1	0	1	0	2	2	2	0	5	2	3	2	5	2	3	1			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr2:106497876G>A	uc002tdg.2	+	4	761	c.319G>A	c.(319-321)GAC>AAC	p.D107N	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Missense_Mutation_p.D107N	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	107					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						CAGCGGCGCCGACCGCATCTA	0.682													9	56					0	0	0	0	A	106497876	A	A	106497876	3	1	162	1	0	0	0	0	1	0	0	0	10274	1058	37	1	325	1	NCK2	2	106497876	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08		106497876	136701497	8	29458											
GLI2	2736	broad.mit.edu	37	chr2	121729595	121729595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgcagcaaggtcaagaccGagcctgagggcctgcggccg	9	3	16	13	4	1	2	1	1	0	1	1	3	1	2	4	3	4	2	4	3	2	0			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr2:121729595G>A	uc010flp.2	+	7	1168	c.1138G>A	c.(1138-1140)GAG>AAG	p.E380K	GLI2_uc002tmq.1_Missense_Mutation_p.E52K|GLI2_uc002tmr.1_Missense_Mutation_p.E52K|GLI2_uc002tmt.3_Missense_Mutation_p.E52K|GLI2_uc002tmu.3_Missense_Mutation_p.E52K|GLI2_uc010flo.1_Missense_Mutation_p.E255K|GLI2_uc002tmw.1_Missense_Mutation_p.E380K	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	380					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GGTCAAGACCGAGCCTGAGGG	0.647													9	62					0	0	0	0	A	121729595	A	A	121729595	3	1	162	1	0	0	0	0	1	0	0	0	6475	1059	37	1	1164	1	GLI2	2	121729595	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	15231719	121729595	121469778	9	29459											
STAM2	10254	broad.mit.edu	37	chr2	153000432	153000432	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atataaagctctcactttccGtgcaaccttattatttaact	12	16	3	10	1	1	0	1	0	1	0	3	0	2	0	2	0	4	2	2	0	7	7	rs137997902		TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr2:153000432G>A	uc002tyc.3	-	7	963	c.613C>T	c.(613-615)CGG>TGG	p.R205W	STAM2_uc010foa.1_Missense_Mutation_p.R205W|STAM2_uc002tyd.2_Missense_Mutation_p.R205W	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	205	SH3.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		CTCACTTTCCGTGCAACCTTA	0.333													6	47					0	0	0	0	A	153000432	A	A	153000432	3	1	162	1	0	0	0	0	1	0	0	0	15315	1144	40	1	996	1	STAM2	2	153000432	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	31270837	153000432	90198941	10	29460											
INPP1	3628	broad.mit.edu	37	chr2	191235874	191235874	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagataccacattcaaatggGactcttgtgctgctcatgcc	11	11	8	11	0	3	1	2	0	1	1	3	2	3	2	2	1	4	2	2	1	3	3			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr2:191235874G>T	uc002ury.3	+	7	1646	c.946G>T	c.(946-948)GAC>TAC	p.D316Y	INPP1_uc010fsb.2_Missense_Mutation_p.D316Y|INPP1_uc002urx.3_Missense_Mutation_p.D316Y	NM_001128928	NP_001122400	P49441	INPP_HUMAN	inositol polyphosphate-1-phosphatase	316		Magnesium 2 (By similarity).|Substrate (By similarity).			signal transduction		inositol-1,4-bisphosphate 1-phosphatase activity|metal ion binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.000286)|Epithelial(96;0.0186)|all cancers(119;0.057)		Lithium(DB01356)	ATTCAAATGGGACTCTTGTGC	0.463													5	94					5.9392e-07	7.73896e-07	1	0	T	191235874	T	T	191235874	3	4	162	1	0	0	0	0	1	0	0	0	7790	1174	41	2	964	2	INPP1	2	191235874	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	38235442	191235874	51963499	11	29461											
DNAJB2	3300	broad.mit.edu	37	chr2	220144591	220144591	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatcctagacgtgccgcgAagtgcgtccgctgatgacat	9	8	13	11	5	0	4	0	2	0	2	2	6	2	4	3	0	2	1	3	0	2	1			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr2:220144591A>T	uc002vkx.1	+	2	273	c.36A>T	c.(34-36)CGA>CGT	p.R12R	DNAJB2_uc010zla.1_Silent_p.R12R|DNAJB2_uc002vkw.1_Silent_p.R12R|DNAJB2_uc002vky.2_5'Flank|DNAJB2_uc010zlb.1_5'Flank	NM_006736	NP_006727	P25686	DNJB2_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 2	12	J.				ER-associated protein catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding|response to unfolded protein	inclusion body	heat shock protein binding|Hsp70 protein binding|polyubiquitin binding|proteasome binding|protein binding|unfolded protein binding				0		Renal(207;0.0474)		Epithelial(149;1.97e-06)|all cancers(144;0.00028)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACGTGCCGCGAAGTGCGTCCG	0.592													15	60					0	0	0	0	T	220144591	T	T	220144591	2	4	162	1	0	0	0	0	0	0	0	1	4642	233	9	5		5	DNAJB2	2	220144591	Silent	SNP	A	TCGA-CR-7397-01A-11D-2012-08	28908717	220144591	23054782	12	29462											
WDR48	57599	broad.mit.edu	37	chr3	39116272	39116272	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtcccttggccagcagaGatgtatagcaacataccgag	11	9	11	10	1	0	1	0	0	0	1	1	3	1	1	3	2	4	3	3	2	4	5			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr3:39116272G>C	uc003cit.2	+	8	738	c.728G>C	c.(727-729)AGA>ACA	p.R243T	WDR48_uc011ayt.1_Missense_Mutation_p.R234T|WDR48_uc011ayu.1_Missense_Mutation_p.R161T|WDR48_uc011ayv.1_Missense_Mutation_p.R35T|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	243	WD 5.				interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GGCCAGCAGAGATGTATAGCA	0.478													14	54					0	0	0	0	C	39116272	C	C	39116272	3	2	162	1	0	0	0	0	1	0	0	0	17369	942	33	2	758	2	WDR48	3	39116272	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08		39116272	158906158	13	29463											
EEFSEC	60678	broad.mit.edu	37	chr3	127983609	127983609	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcctcggtgacagtgtggaGatccctgccctcaaggtcag	8	8	13	12	1	2	2	2	1	0	1	4	3	3	2	3	3	2	0	3	3	1	0			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr3:127983609G>A	uc003eki.2	+	4	809	c.771G>A	c.(769-771)GAG>GAA	p.E257E	EEFSEC_uc003ekj.2_Intron	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	257						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						ACAGTGTGGAGATCCCTGCCC	0.567													7	58					0	0	0	0	A	127983609	A	A	127983609	2	1	162	1	0	0	0	0	0	0	0	1	4953	933	33	2		2	EEFSEC	3	127983609	Silent	SNP	G	TCGA-CR-7397-01A-11D-2012-08	88867337	127983609	70038821	14	29464											
AFAP1	60312	broad.mit.edu	37	chr4	7840316	7840316	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcgggtccgtgccctgctGagtaatcttcagctcgtgct	6	11	12	12	3	2	1	1	1	1	0	4	1	3	1	2	1	5	4	2	1	2	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr4:7840316G>C	uc003gkg.1	-	6	934	c.661C>G	c.(661-663)CAG>GAG	p.Q221E	AFAP1_uc011bwk.1_Missense_Mutation_p.Q221E	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	221	PH 1.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						GTGCCCTGCTGAGTAATCTTC	0.532													3	77					0	0	0	0	C	7840316	C	C	7840316	3	2	162	1	0	0	0	0	1	0	0	0	353	1299	45	2	1835	2	AFAP1	4	7840316	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08		7840316	183313960	15	29465											
KCTD8	386617	broad.mit.edu	37	chr4	44450256	44450256	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccggtcgatgaagaagcgCgcccggctgtccctgggcag	6	6	15	14	5	0	2	0	1	0	1	3	3	2	2	3	3	1	2	3	3	2	0			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr4:44450256C>T	uc003gwu.2	-	1	569	c.285G>A	c.(283-285)GCG>GCA	p.A95A		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	95	BTB.					cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TGAAGAAGCGCGCCCGGCTGT	0.557										HNSCC(17;0.042)			4	24					0	0	0	0	T	44450256	T	T	44450256	2	4	162	1	0	0	0	0	0	0	0	1	8154	755	27	1		1	KCTD8	4	44450256	Silent	SNP	C	TCGA-CR-7397-01A-11D-2012-08	36609940	44450256	146704020	16	29466											
NAA11	84779	broad.mit.edu	37	chr4	80246805	80246805	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccggtgtgaacgcttcacgGccagtgaggtgatatggcca	8	8	15	10	3	1	3	1	3	0	0	1	3	1	3	3	4	1	1	3	4	2	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr4:80246805G>A	uc003hlt.3	-	1	367	c.227C>T	c.(226-228)GCC>GTC	p.A76V		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	76	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						ACGCTTCACGGCCAGTGAGGT	0.562													10	96					0	0	0	0	A	80246805	A	A	80246805	3	1	162	1	0	0	0	0	1	0	0	0	10170	1203	42	4	466	4	NAA11	4	80246805	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	35796549	80246805	110907471	17	29467											
FAM13A	10144	broad.mit.edu	37	chr4	89950619	89950619	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttaactcaccatgctgcGtcaaatattccactatattc	12	13	4	12	1	2	0	2	0	0	0	4	1	3	0	2	0	3	1	2	0	5	6			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr4:89950619G>A	uc003hse.1	-	2	417	c.209C>T	c.(208-210)ACG>ATG	p.T70M	FAM13A_uc003hsf.1_Translation_Start_Site|FAM13A_uc003hsh.1_Translation_Start_Site|FAM13A_uc003hsi.2_Missense_Mutation_p.T70M|FAM13A_uc003hsj.2_Missense_Mutation_p.T70M	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	70	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						ACCATGCTGCGTCAAATATTC	0.393													4	152					0	0	0	0	A	89950619	A	A	89950619	3	1	162	1	0	0	0	0	1	0	0	0	5480	1145	40	1	2987	1	FAM13A	4	89950619	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	9703814	89950619	101203657	18	29468											
NPY5R	4889	broad.mit.edu	37	chr4	164272135	164272135	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcatacaagtgtctgcagaaGtataagctgtggattgtcca	12	12	10	7	0	2	1	1	0	1	1	3	2	3	2	1	1	3	3	1	1	5	4			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr4:164272135G>A	uc003iqn.2	+	4	892	c.710G>A	c.(709-711)AGT>AAT	p.S237N		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	237	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				GTCTGCAGAAGTATAAGCTGT	0.368													19	61					0	0	0	0	A	164272135	A	A	164272135	3	1	162	1	0	0	0	0	1	0	0	0	10664	1029	36	4	712	4	NPY5R	4	164272135	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	74321516	164272135	26882141	19	29469											
VCAN	1462	broad.mit.edu	37	chr5	82817997	82817997	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcctcctgctacacagccaaCaagaccacccactgtggaag	12	6	7	16	0	0	1	0	0	0	1	2	2	2	2	5	1	4	1	5	1	4	1			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr5:82817997C>G	uc003kii.3	+	7	4228	c.3872C>G	c.(3871-3873)ACA>AGA	p.T1291R	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.T1291R|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1291	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACACAGCCAACAAGACCACCC	0.478													13	86					0	0	0	0	G	82817997	G	G	82817997	3	3	162	1	0	0	0	0	1	0	0	0	17206	478	17	4	3894	4	VCAN	5	82817997	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08		82817997	98097263	20	29470											
KDM3B	51780	broad.mit.edu	37	chr5	137727716	137727716	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctgtgaaaaggttctcaCtggatgaacgaagcttggct	12	10	12	7	1	1	2	1	2	1	0	2	4	1	3	0	3	3	4	0	3	5	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr5:137727716C>T	uc003lcy.1	+	8	2595	c.2395C>T	c.(2395-2397)CTG>TTG	p.L799L	KDM3B_uc010jew.1_Silent_p.L455L|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	799					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AAGGTTCTCACTGGATGAACG	0.512													29	207					0	0	0	0	T	137727716	T	T	137727716	2	4	162	1	0	0	0	0	0	0	0	1	8166	564	20	4		4	KDM3B	5	137727716	Silent	SNP	C	TCGA-CR-7397-01A-11D-2012-08	54909719	137727716	43187544	21	29471											
CDHR2	54825	broad.mit.edu	37	chr5	176018404	176018404	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgaccaggctttctctccaGagccaaccccatgctgaacc	9	9	7	16	0	1	3	0	2	1	1	3	3	2	3	6	1	4	2	6	1	2	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr5:176018404G>A	uc003mem.1	+	30	3720	c.3654_splice	c.e30-1	p.R1218_splice	CDHR2_uc003men.1_Splice_Site_p.R1218_splice	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor						homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						TTTCTCTCCAGAGCCAACCCC	0.577													11	53					0	0	0	0	A	176018404	A	A	176018404	5	1	162	1	0	0	0	0	0	0	1	0	3134	956	33	2	3767	2	CDHR2	5	176018404	Splice_Site	SNP	G	TCGA-CR-7397-01A-11D-2012-08	38290688	176018404	4896856	22	29472											
C6orf27	80737	broad.mit.edu	37	chr6	31736952	31736952	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagctcgaccctgaacccttGatgtatcttcagtcaccagg	9	10	9	13	1	3	2	2	2	1	0	4	4	3	2	3	1	2	2	3	1	2	3			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr6:31736952G>C	uc011dog.1	-	10	1584	c.1346C>G	c.(1345-1347)TCA>TGA	p.S449*	C6orf27_uc003nxd.2_Nonsense_Mutation_p.S124*|C6orf27_uc011doh.1_RNA	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	449						extracellular region				ovary(3)	3						CTGAACCCTTGATGTATCTTC	0.522													4	66					0	0	0	0	C	31736952	C	C	31736952	4	2	162	1	0	0	0	0	0	1	0	0	2372	1294	45	2	1360	2	C6orf27	6	31736952	Nonsense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08		31736952	139378115	23	29473											
PTK7	5754	broad.mit.edu	37	chr6	43113061	43113061	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagcagcagctggacttccGgagggagttggagatgtttg	8	9	17	7	1	0	1	0	0	0	1	1	5	1	4	1	4	3	6	1	4	0	3			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr6:43113061G>A	uc003oub.1	+	16	2729	c.2531G>A	c.(2530-2532)CGG>CAG	p.R844Q	PTK7_uc003ouc.1_Missense_Mutation_p.R788Q|PTK7_uc003oud.1_Missense_Mutation_p.R804Q|PTK7_uc003oue.1_Missense_Mutation_p.R714Q|PTK7_uc003ouf.1_Intron|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Missense_Mutation_p.R852Q|PTK7_uc010jyj.1_Missense_Mutation_p.R170Q	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	844	Cytoplasmic (Potential).|Protein kinase; inactive.|Interaction with CTNNB1.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CTGGACTTCCGGAGGGAGTTG	0.602													13	52					0	0	0	0	A	43113061	A	A	43113061	3	1	162	1	0	0	0	0	1	0	0	0	12828	1116	39	1	2593	1	PTK7	6	43113061	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	11376109	43113061	128002006	24	29474											
TXLNB	167838	broad.mit.edu	37	chr6	139609822	139609822	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccctgctgtgctggcagcaGacccataagtgttaatgatg	9	11	11	10	0	0	2	0	1	0	1	1	2	1	2	2	1	3	5	2	1	2	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr6:139609822G>C	uc011eds.1	-	2	380	c.215C>G	c.(214-216)TCT>TGT	p.S72C		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	72						cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		GCTGGCAGCAGACCCATAAGT	0.542													14	118					0	0	0	0	C	139609822	C	C	139609822	3	2	162	1	0	0	0	0	1	0	0	0	16856	942	33	2	1875	2	TXLNB	6	139609822	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	96496761	139609822	31505245	25	29475											
AUTS2	26053	broad.mit.edu	37	chr7	70236612	70236612	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcccttttggttcactacaAggagcatttcagccgaaggt	9	11	11	10	1	2	0	2	0	0	0	2	2	2	1	2	4	3	2	2	4	3	5			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr7:70236612A>G	uc003tvw.3	+	11	2555	c.1812A>G	c.(1810-1812)CAA>CAG	p.Q604Q	AUTS2_uc003tvx.3_Silent_p.Q604Q|AUTS2_uc011keg.1_Silent_p.Q56Q	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	604										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GTTCACTACAAGGAGCATTTC	0.567													8	99					0	0	0	0	G	70236612	G	G	70236612	2	3	162	1	0	0	0	0	0	0	0	1	1227	69	3	5		5	AUTS2	7	70236612	Silent	SNP	A	TCGA-CR-7397-01A-11D-2012-08		70236612	88902051	26	29476											
CADPS2	93664	broad.mit.edu	37	chr7	122194724	122194724	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctgatttggagctattaGaagttgggtataatatcacc	12	13	10	6	0	1	2	1	1	0	1	1	3	1	3	1	2	2	4	1	2	6	7			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr7:122194724G>C	uc010lkp.2	-	8	1518	c.1355C>G	c.(1354-1356)TCT>TGT	p.S452C	CADPS2_uc003vkg.3_Missense_Mutation_p.S152C|CADPS2_uc010lkq.2_Missense_Mutation_p.S452C	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	452					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						GGAGCTATTAGAAGTTGGGTA	0.358													4	31					0	0	0	0	C	122194724	C	C	122194724	3	2	162	1	0	0	0	0	1	0	0	0	2583	942	33	2	2671	2	CADPS2	7	122194724	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	51958112	122194724	36943939	27	29477											
PODXL	5420	broad.mit.edu	37	chr7	131195709	131195709	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggggtggccacaggatgcGtcgaagtgggttgtcggggg	5	9	21	6	3	0	0	0	0	0	0	2	2	0	1	1	7	1	1	1	7	1	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr7:131195709G>A	uc003vqw.3	-	2	842	c.584C>T	c.(583-585)ACG>ATG	p.T195M	PODXL_uc003vqx.3_Missense_Mutation_p.T195M	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	podocalyxin-like isoform 1 precursor	195	Thr-rich.|Extracellular (Potential).				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)					CACAGGATGCGTCGAAGTGGG	0.537													6	81					0	0	0	0	A	131195709	A	A	131195709	3	1	162	1	0	0	0	0	1	0	0	0	12235	1145	40	1	1124	1	PODXL	7	131195709	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	9000985	131195709	27942954	28	29478											
ABP1	26	broad.mit.edu	37	chr7	150553561	150553561	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagccgtggagcgagagatGccggccctgggctgggccgt	6	5	19	11	4	0	2	0	0	0	2	0	5	0	3	4	4	3	1	4	4	0	0			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr7:150553561G>A	uc003why.1	+	3	4221	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ABP1_uc003whz.1_Missense_Mutation_p.M1I|ABP1_uc003wia.1_Missense_Mutation_p.M1I	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	1					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	AGCGAGAGATGCCGGCCCTGG	0.607													6	48					0	0	0	0	A	150553561	A	A	150553561	3	1	162	1	0	0	0	0	1	0	0	0	98	1319	46	4	5	4	ABP1	7	150553561	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	19357852	150553561	8585102	29	29479											
PTCH1	5727	broad.mit.edu	37	chr9	98220448	98220448	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccgttggggtaactggacagCcccaggctcgtatagttgct	7	10	13	11	2	0	0	0	0	0	0	1	1	0	1	3	4	3	6	3	4	3	5			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr9:98220448C>A	uc004avk.3	-	18	3203	c.3015G>T	c.(3013-3015)GGG>GGT	p.G1005G	PTCH1_uc010mro.2_Silent_p.G854G|PTCH1_uc010mrp.2_Silent_p.G854G|PTCH1_uc010mrq.2_Silent_p.G854G|PTCH1_uc004avl.3_Silent_p.G854G|PTCH1_uc010mrr.2_Silent_p.G939G|PTCH1_uc004avm.3_Silent_p.G1004G	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1005	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.I963fs*2(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AACTGGACAGCCCCAGGCTCG	0.567									Basal_Cell_Nevus_syndrome				22	68					0.000295444	0.000379226	1	0	A	98220448	A	A	98220448	2	1	162	1	0	0	0	0	0	0	0	1	12792	726	26	4		4	PTCH1	9	98220448	Silent	SNP	C	TCGA-CR-7397-01A-11D-2012-08		98220448	42992983	30	29480											
ADARB2	105	broad.mit.edu	37	chr10	1284215	1284215	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggtgcagctccagctgcGtgtagaggaagtgcaggaac	10	7	15	9	1	1	1	1	0	0	1	2	3	2	3	1	3	6	5	1	3	3	1			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr10:1284215G>A	uc009xhq.2	-	5	1714	c.1340C>T	c.(1339-1341)ACG>ATG	p.T447M		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	447	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CTCCAGCTGCGTGTAGAGGAA	0.701													4	19					0	0	0	0	A	1284215	A	A	1284215	3	1	162	1	0	0	0	0	1	0	0	0	283	1145	40	1	903	1	ADARB2	10	1284215	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08		1284215	134250532	31	29481											
TMEM216	51259	broad.mit.edu	37	chr11	61165278	61165278	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acctctgccagcgaaagatgCcgctcagtattagcgtggcc	9	8	11	13	3	2	1	1	0	1	1	2	2	2	1	4	1	4	2	4	1	3	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr11:61165278C>T	uc010rlj.1	+	4	534	c.241C>T	c.(241-243)CCG>TCG	p.P81S	TMEM216_uc001nrn.1_Missense_Mutation_p.P27S	NM_016499	NP_057583	Q9P0N5	TM216_HUMAN	transmembrane protein 216	81						integral to membrane					0						GCGAAAGATGCCGCTCAGTAT	0.552													4	124					0	0	0	0	T	61165278	T	T	61165278	3	4	162	1	0	0	0	0	1	0	0	0	16205	739	26	4	276	4	TMEM216	11	61165278	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08		61165278	73841238	32	29482											
H3F3C	440093	broad.mit.edu	37	chr12	31944914	31944914	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctctggaagggcagcttccGgatgagcagctcggtcgact	7	8	14	12	3	1	1	0	1	1	0	4	4	2	3	2	4	3	4	2	4	1	1			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr12:31944914G>A	uc001rkr.2	-	1	262	c.187C>T	c.(187-189)CGG>TGG	p.R63W		NM_001013699	NP_001013721	Q6NXT2	H3C_HUMAN	histone H3-like	63					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GGCAGCTTCCGGATGAGCAGC	0.612										HNSCC(67;0.2)			3	85					0	0	0	0	A	31944914	A	A	31944914	3	1	162	1	0	0	0	0	1	0	0	0	6974	1115	39	1	224	1	H3F3C	12	31944914	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08		31944914	101906981	33	29483											
SMARCC2	6601	broad.mit.edu	37	chr12	56572620	56572620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtcgtctccatgctttcatCttcctgttcatctgaaagag	7	15	7	12	2	5	2	2	1	3	1	8	2	6	2	2	0	1	2	2	0	1	3			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr12:56572620C>T	uc001skb.2	-	13	1259	c.1153G>A	c.(1153-1155)GAT>AAT	p.D385N	SMARCC2_uc001skd.2_Missense_Mutation_p.D385N|SMARCC2_uc001ska.2_Missense_Mutation_p.D385N|SMARCC2_uc001skc.2_Missense_Mutation_p.D385N|SMARCC2_uc010sqf.1_Missense_Mutation_p.D274N	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	385					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			ATGCTTTCATCTTCCTGTTCA	0.483													4	46					0	0	0	0	T	56572620	T	T	56572620	3	4	162	1	0	0	0	0	1	0	0	0	14840	913	32	2	2652	2	SMARCC2	12	56572620	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08	24627706	56572620	77279275	34	29484											
SMARCC2	6601	broad.mit.edu	37	chr12	56575490	56575490	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaacaggatttgtcacctCatctgtcagtgtcttggctg	9	13	10	9	0	5	1	3	0	2	1	5	2	5	2	1	2	1	1	1	2	2	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr12:56575490C>A	uc001skb.2	-	9	944	c.838G>T	c.(838-840)GAG>TAG	p.E280*	SMARCC2_uc001skd.2_Nonsense_Mutation_p.E280*|SMARCC2_uc001ska.2_Nonsense_Mutation_p.E280*|SMARCC2_uc001skc.2_Nonsense_Mutation_p.E280*|SMARCC2_uc010sqf.1_Nonsense_Mutation_p.E169*	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	280					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TTTGTCACCTCATCTGTCAGT	0.433													9	113					0.00621372	0.00774463	1	0	A	56575490	A	A	56575490	4	1	162	1	0	0	0	0	0	1	0	0	14840	835	29	2	2983	2	SMARCC2	12	56575490	Nonsense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08	2870	56575490	77276405	35	29485											
PIWIL1	9271	broad.mit.edu	37	chr12	130840124	130840124	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taatgttcaaagggagcttcGagactggggtttgagctttg	9	13	14	5	1	1	2	1	1	0	1	2	4	1	3	0	3	2	4	0	3	2	5			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr12:130840124G>A	uc001uik.2	+	12	1406	c.1316G>A	c.(1315-1317)CGA>CAA	p.R439Q	PIWIL1_uc001uij.1_Missense_Mutation_p.R439Q	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	439					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		AGGGAGCTTCGAGACTGGGGT	0.393													15	158					0	0	0	0	A	130840124	A	A	130840124	3	1	162	1	0	0	0	0	1	0	0	0	12012	1058	37	1	1358	1	PIWIL1	12	130840124	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	74264634	130840124	3011771	36	29486											
MUDENG	55745	broad.mit.edu	37	chr14	57746958	57746958	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgttaccatcagcttgagtCtccccaccaatggatctcca	10	11	6	14	0	3	1	1	1	2	0	5	2	3	2	5	1	2	2	5	1	2	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr14:57746958C>T	uc001xcv.2	+	3	1193	c.766C>T	c.(766-768)CTC>TTC	p.L256F	MUDENG_uc010tri.1_Missense_Mutation_p.L10F|MUDENG_uc010trj.1_Missense_Mutation_p.L153F	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	256	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1						CAGCTTGAGTCTCCCCACCAA	0.398													10	172					0	0	0	0	T	57746958	T	T	57746958	3	4	162	1	0	0	0	0	1	0	0	0	10036	913	32	2	776	2	MUDENG	14	57746958	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08		57746958	49602582	37	29487											
EML5	161436	broad.mit.edu	37	chr14	89130941	89130941	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tatctataaagctgtcatggGatgctacagcaagatatttc	13	13	8	7	0	2	1	1	0	1	1	3	2	2	2	0	1	4	3	0	1	7	6			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr14:89130941G>C	uc001xxg.2	-	24	3491	c.3305C>G	c.(3304-3306)TCC>TGC	p.S1102C	EML5_uc001xxf.2_Translation_Start_Site|EML5_uc001xxh.1_Missense_Mutation_p.S241C	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1102	WD 18.					cytoplasm|microtubule				ovary(3)	3						GCTGTCATGGGATGCTACAGC	0.328													4	65					0	0	0	0	C	89130941	C	C	89130941	3	2	162	1	0	0	0	0	1	0	0	0	5124	1174	41	2	2712	2	EML5	14	89130941	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	31383983	89130941	18218599	38	29488											
HERC2	8924	broad.mit.edu	37	chr15	28538128	28538128	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttttttctctttgtcattCagatcttctttctttgttcc	3	25	3	10	0	7	1	2	0	5	1	9	1	8	1	1	0	0	1	1	0	0	9			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr15:28538128C>T	uc001zbj.2	-	4	334	c.228G>A	c.(226-228)CTG>CTA	p.L76L	HERC2_uc001zbl.1_5'UTR	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	76					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTTTGTCATTCAGATCTTCTT	0.393													8	71					0	0	0	0	T	28538128	T	T	28538128	2	4	162	1	0	0	0	0	0	0	0	1	7097	813	29	2		2	HERC2	15	28538128	Silent	SNP	C	TCGA-CR-7397-01A-11D-2012-08		28538128	73993264	39	29489											
KIAA0556	23247	broad.mit.edu	37	chr16	27751578	27751578	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctggtgccagcggggacaagGagcttggtctcggttgctca	6	9	16	10	2	2	0	1	0	1	0	3	2	2	2	1	6	4	3	1	6	1	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr16:27751578G>A	uc002dow.2	+	15	1984	c.1960G>A	c.(1960-1962)GAG>AAG	p.E654K		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	654										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						CGGGGACAAGGAGCTTGGTCT	0.507													6	68					0	0	0	0	A	27751578	A	A	27751578	3	1	162	1	0	0	0	0	1	0	0	0	8222	1175	41	2	2018	2	KIAA0556	16	27751578	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08		27751578	62603175	40	29490											
KIAA0182	23199	broad.mit.edu	37	chr16	85699645	85699645	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgttgctgcttccttgtCtgacatcccaaaggccgcgg	5	12	12	12	2	1	1	0	1	1	0	3	1	3	1	3	3	2	3	3	3	1	3			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr16:85699645C>T	uc002fix.2	+	13	2896	c.2822C>T	c.(2821-2823)TCT>TTT	p.S941F	KIAA0182_uc002fiw.2_Missense_Mutation_p.S837F|KIAA0182_uc002fiy.2_Missense_Mutation_p.S868F|KIAA0182_uc002fiz.2_Missense_Mutation_p.S83F|KIAA0182_uc010cho.2_Missense_Mutation_p.S121F	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	941							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						GCTTCCTTGTCTGACATCCCA	0.567													3	44					0	0	0	0	T	85699645	T	T	85699645	3	4	162	1	0	0	0	0	1	0	0	0	8198	913	32	2	2872	2	KIAA0182	16	85699645	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08	57948067	85699645	4655108	41	29491											
TRPV1	7442	broad.mit.edu	37	chr17	3470183	3470183	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagagaccctgaaaactgtcGcagataaacttcctcgggct	12	8	9	12	2	0	3	0	1	0	2	3	4	1	3	2	1	2	2	2	1	4	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr17:3470183G>A	uc010vrr.1	-	15	2973	c.2446C>T	c.(2446-2448)CGA>TGA	p.R816*	TRPV1_uc010vro.1_Nonsense_Mutation_p.R827*|TRPV1_uc010vrp.1_Nonsense_Mutation_p.R756*|TRPV1_uc010vrq.1_Nonsense_Mutation_p.R814*|TRPV1_uc010vrs.1_Nonsense_Mutation_p.R816*|TRPV1_uc010vrt.1_Nonsense_Mutation_p.R816*|TRPV1_uc010vru.1_Nonsense_Mutation_p.R816*	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,	816	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	GAAAACTGTCGCAGATAAACT	0.547													5	39					0	0	0	0	A	3470183	A	A	3470183	4	1	162	1	0	0	0	0	0	1	0	0	16662	1095	38	1	77	1	TRPV1	17	3470183	Nonsense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08		3470183	77725027	42	29492											
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	6	8	16	11	2	1	1	1	1	0	0	2	3	2	2	4	5	2	2	4	5	0	1	rs121912651		TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	50					0	0	0	0	A	7577539	A	A	7577539	3	1	162	1	0	0	0	0	1	0	0	0	16448	1115	39	1	548	1	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08	4107356	7577539	73617671	43	29493											
KCNJ12	3768	broad.mit.edu	37	chr17	21319866	21319866	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccgaagccgggacggcctCagcccccaggccaggcatga	8	2	15	16	3	1	1	1	1	0	0	1	3	1	2	6	5	2	1	6	5	1	0			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr17:21319866C>T	uc002gyv.1	+	3	1917	c.1212C>T	c.(1210-1212)CTC>CTT	p.L404L		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	404	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	GGGACGGCCTCAGCCCCCAGG	0.662										Prostate(3;0.18)			5	75					0	0	0	0	T	21319866	T	T	21319866	2	4	162	1	0	0	0	0	0	0	0	1	8085	813	29	2		2	KCNJ12	17	21319866	Silent	SNP	C	TCGA-CR-7397-01A-11D-2012-08	13742327	21319866	59875344	44	29494											
PSMD3	5709	broad.mit.edu	37	chr17	38142872	38142872	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttccgtccccgcacgggAaaagctgcgtcgacacccct	8	6	10	17	5	0	0	0	0	0	0	3	2	2	1	5	1	2	3	5	1	2	1			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr17:38142872A>G	uc002htn.1	+	3	620	c.456A>G	c.(454-456)GGA>GGG	p.G152G	PSMD3_uc010wen.1_RNA|PSMD3_uc010weo.1_Silent_p.G53G	NM_002809	NP_002800	O43242	PSMD3_HUMAN	proteasome 26S non-ATPase subunit 3	152					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			ovary(1)|pancreas(1)	2	Colorectal(19;0.000442)					CCCGCACGGGAAAAGCTGCGT	0.512													3	184					0	0	0	0	G	38142872	G	G	38142872	2	3	162	1	0	0	0	0	0	0	0	1	12761	233	9	5		5	PSMD3	17	38142872	Silent	SNP	A	TCGA-CR-7397-01A-11D-2012-08	16823006	38142872	43052338	45	29495											
SERPINB4	6318	broad.mit.edu	37	chr18	61309020	61309020	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattgatacgtcttttctcCgaagagcttgttggcgatct	9	15	9	8	3	3	2	0	1	3	1	4	4	3	2	1	1	2	2	1	1	3	6			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr18:61309020C>T	uc002ljf.2	-	4	411	c.325G>A	c.(325-327)GGA>AGA	p.G109R	SERPINB4_uc002lje.2_Missense_Mutation_p.G109R|SERPINB4_uc002ljg.2_Intron	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	109					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						GTCTTTTCTCCGAAGAGCTTG	0.413													11	80					0	0	0	0	T	61309020	T	T	61309020	3	4	162	1	0	0	0	0	1	0	0	0	14168	661	23	1	867	1	SERPINB4	18	61309020	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08		61309020	16768228	46	29496											
ZNF208	7757	broad.mit.edu	37	chr19	22154658	22154658	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaggctttgccacattcttCacatttgtagggtttttctc	7	17	8	9	0	3	0	1	0	2	0	4	1	3	0	1	2	1	3	1	2	2	7			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:22154658C>T	uc002nqp.2	-	6	2943	c.2794G>A	c.(2794-2796)GAA>AAA	p.E932K	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCACATTCTTCACATTTGTAG	0.463													8	145					0	0	0	0	T	22154658	T	T	22154658	3	4	162	1	0	0	0	0	1	0	0	0	17833	835	29	2	668	2	ZNF208	19	22154658	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08		22154658	36974325	47	29497											
ZNF675	171392	broad.mit.edu	37	chr19	23836193	23836193	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggatcggctaaaagctttGccacattcttcacatttgta	11	13	8	9	1	2	0	1	0	1	0	3	2	2	1	1	2	2	3	1	2	3	6			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:23836193G>A	uc002nri.2	-	4	1724	c.1542C>T	c.(1540-1542)GGC>GGT	p.G514G		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	514	C2H2-type 14.			G -> S (in Ref. 1; AAK95822).	bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TAAAAGCTTTGCCACATTCTT	0.368													7	35					0	0	0	0	A	23836193	A	A	23836193	2	1	162	1	0	0	0	0	0	0	0	1	18149	1306	46	4		4	ZNF675	19	23836193	Silent	SNP	G	TCGA-CR-7397-01A-11D-2012-08	1681535	23836193	35292790	48	29498											
RINL	126432	broad.mit.edu	37	chr19	39361610	39361610	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttcacccaggagaccccGtgaggcgcagggttcctggg	6	7	14	14	2	1	2	1	1	0	1	2	3	2	2	5	4	0	2	5	4	0	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:39361610G>A	uc002ojq.2	-	8	670	c.282C>T	c.(280-282)CAC>CAT	p.H94H	RINL_uc002ojr.1_5'Flank|RINL_uc010xuo.1_Silent_p.H208H	NM_198445	NP_940847	Q6ZS11	RINL_HUMAN	Ras and Rab interactor-like	94							GTPase activator activity			pancreas(1)	1						AGGAGACCCCGTGAGGCGCAG	0.672													13	96					0	0	0	0	A	39361610	A	A	39361610	2	1	162	1	0	0	0	0	0	0	0	1	13440	1136	40	1		1	RINL	19	39361610	Silent	SNP	G	TCGA-CR-7397-01A-11D-2012-08	15525417	39361610	19767373	49	29499											
FCGBP	8857	broad.mit.edu	37	chr19	40368837	40368837	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccactgaaatccgcccgtCggccacggagacaggcaagg	10	3	14	14	4	0	2	0	1	0	1	2	3	1	2	4	5	0	1	4	5	2	0			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:40368837C>T	uc002omp.3	-	28	12519	c.12511G>A	c.(12511-12513)GAC>AAC	p.D4171N		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4171	VWFD 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ATCCGCCCGTCGGCCACGGAG	0.617													6	433					0	0	0	0	T	40368837	T	T	40368837	3	4	162	1	0	0	0	0	1	0	0	0	5810	884	31	1	3742	1	FCGBP	19	40368837	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08	1007227	40368837	18760146	50	29500											
PLA2G4C	8605	broad.mit.edu	37	chr19	48607904	48607904	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaacaggccctgttctttCatctcactcaggaccccaag	9	10	6	16	0	4	0	3	0	2	0	6	1	5	1	4	2	1	1	4	2	2	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:48607904C>T	uc002phx.2	-	4	596	c.198G>A	c.(196-198)ATG>ATA	p.M66I	PLA2G4C_uc002phw.2_Missense_Mutation_p.M1I|PLA2G4C_uc010elr.2_Missense_Mutation_p.M66I|PLA2G4C_uc010xzd.1_Missense_Mutation_p.M76I|PLA2G4C_uc002phy.3_Missense_Mutation_p.M66I	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	66	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CCTGTTCTTTCATCTCACTCA	0.547													9	95					0	0	0	0	T	48607904	T	T	48607904	3	4	162	1	0	0	0	0	1	0	0	0	12058	826	29	2	1487	2	PLA2G4C	19	48607904	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08	8239067	48607904	10521079	51	29501											
ZNF473	25888	broad.mit.edu	37	chr19	50548556	50548556	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctgtggcatcagaaaactCacactggagaaaaaccatgt	16	7	8	10	0	2	2	2	0	0	2	2	3	2	2	2	2	2	1	2	2	4	0			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr19:50548556C>G	uc002prn.2	+	5	1093	c.856C>G	c.(856-858)CAC>GAC	p.H286D	ZNF473_uc002prm.2_Missense_Mutation_p.H286D|ZNF473_uc010ybo.1_Missense_Mutation_p.H274D	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	286	C2H2-type 2; degenerate.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		TCAGAAAACTCACACTGGAGA	0.428													8	94					0	0	0	0	G	50548556	G	G	50548556	3	3	162	1	0	0	0	0	1	0	0	0	17998	826	29	2	870	2	ZNF473	19	50548556	Missense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08	1940652	50548556	8580427	52	29502											
TRPM2	7226	broad.mit.edu	37	chr21	45837846	45837846	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcaggagcacacggaccaGatttggaagttccagcgcca	11	6	13	11	2	0	1	0	0	0	1	1	4	1	4	3	3	3	3	3	3	1	2			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chr21:45837846G>C	uc002zet.1	+	22	3396	c.3183G>C	c.(3181-3183)CAG>CAC	p.Q1061H	TRPM2_uc002zeu.1_Missense_Mutation_p.Q1061H|TRPM2_uc002zew.1_Missense_Mutation_p.Q1061H|TRPM2_uc010gpt.1_Missense_Mutation_p.Q1061H|TRPM2_uc002zex.1_Missense_Mutation_p.Q847H|TRPM2_uc002zey.1_Missense_Mutation_p.Q574H|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1061	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACACGGACCAGATTTGGAAGT	0.488													4	66					0	0	0	0	C	45837846	C	C	45837846	3	2	162	1	0	0	0	0	1	0	0	0	16653	933	33	2	3265	2	TRPM2	21	45837846	Missense_Mutation	SNP	G	TCGA-CR-7397-01A-11D-2012-08		45837846	2292049	53	29503											
MTMR8	55613	broad.mit.edu	37	chrX	63444272	63444272	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaatatccagctggttgatGgcttgtggctggccagcctg	6	11	15	9	0	0	1	0	1	0	0	1	2	1	2	3	5	2	4	3	5	2	3			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chrX:63444272G>A	uc011mou.1	-	11	2093	c.2025C>T	c.(2023-2025)GCC>GCT	p.A675A	ASB12_uc004dvp.1_Silent_p.A291A|ASB12_uc004dvq.1_Silent_p.A300A|ASB12_uc004dvr.1_Silent_p.A300A	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	Error:Variant_position_missing_in_Q96EF0_after_alignment						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						GCTGGTTGATGGCTTGTGGCT	0.507													4	36					0	0	0	0	A	63444272	A	A	63444272	2	1	162	1	0	0	0	0	0	0	0	1	10002	1335	47	4		4	MTMR8	23	63444272	Silent	SNP	G	TCGA-CR-7397-01A-11D-2012-08		63444272	91826288	54	29504											
NKAP	79576	broad.mit.edu	37	chrX	119077227	119077227	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccttgtcgaggaggctaggCcaaggcttgtcgctcccgta	6	10	13	12	3	0	0	0	0	0	0	4	2	2	1	3	4	0	4	3	4	3	4			TCGA-CR-7397-01A-11D-2012-08	TCGA-CR-7397-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b93863c2-4657-4ca2-8fce-094fe5df163a	acce94e0-e7f7-45af-adb3-fc1611312cbd	g.chrX:119077227C>T	uc004esh.2	-	1	509	c.342G>A	c.(340-342)TGG>TGA	p.W114*		NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	114					negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						GGAGGCTAGGCCAAGGCTTGT	0.637													8	39					0	0	0	0	T	119077227	T	T	119077227	4	4	162	1	0	0	0	0	0	1	0	0	10493	740	26	4	941	4	NKAP	23	119077227	Nonsense_Mutation	SNP	C	TCGA-CR-7397-01A-11D-2012-08	55632955	119077227	36193333	55	29505											
PRAMEF1	65121	broad.mit.edu	37	chr1	12853591	12853591	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgggatcactgatgaagaCgcttcatttggagaccttaa	11	12	10	8	1	3	4	2	2	1	2	3	6	3	5	1	2	0	1	1	2	2	3	rs149382773		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:12853591C>A	uc001auj.1	+	2	318	c.215C>A	c.(214-216)ACG>AAG	p.T72K		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	72											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGATGAAGACGCTTCATTTG	0.547													59	97					1.88935e-48	7.36347e-48	1	0	A	12853591	A	A	12853591	3	1	163	1	0	0	0	0	1	0	0	0	12485	536	19	3	217	3	PRAMEF1	1	12853591	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08		12853591	236397030	1	29506											
PRAMEF2	65122	broad.mit.edu	37	chr1	12919600	12919600	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgttgatgagaatttctggGccagatggcctggagcctgg	8	11	15	7	0	1	3	0	2	1	2	1	5	1	4	3	4	1	1	3	4	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:12919600G>C	uc001aum.1	+	3	427	c.340G>C	c.(340-342)GCC>CCC	p.A114P		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	114											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAATTTCTGGGCCAGATGGCC	0.557													149	238					0	0	0	0	C	12919600	C	C	12919600	3	2	163	1	0	0	0	0	1	0	0	0	12495	1203	42	4	346	4	PRAMEF2	1	12919600	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	66009	12919600	236331021	2	29507											
PRAMEF18	391003	broad.mit.edu	37	chr1	13474788	13474788	+	Frame_Shift_Del	DEL	G	-	-																															ggaccaaagaagatcctgttGggctcccttacttccctcag																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:13474788delG	uc009vnu.1	-	3	1388	c.1341delC	c.(1339-1341)CCCfs	p.P447fs		NM_001099850	NP_001093320	Q5VWM3	PRA18_HUMAN	PRAME family member 18	447											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGATCCTGTTGGGCTCCCTTA	0.562													---	---	---								-	13474788	-	-	13474788	7	5	163	1	0	1	0	1	0	0	0	0	12493	1335	47	0	102	0	PRAMEF18	1	13474788	Frame_Shift_Del	DEL	G	TCGA-CR-7398-01A-11D-2012-08	555188	13474788	235775833	3	29508											
OPRD1	4985	broad.mit.edu	37	chr1	29185538	29185538	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccgatgcgctggccaccagCacgctgcctttccagagtgc	6	7	12	16	3	0	1	0	0	0	1	1	2	1	1	5	1	4	3	5	1	0	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:29185538C>G	uc001brf.1	+	2	542	c.300C>G	c.(298-300)AGC>AGG	p.S100R		NM_000911	NP_000902	P41143	OPRD_HUMAN	opioid receptor, delta 1	100	Helical; Name=2; (Potential).				immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	TGGCCACCAGCACGCTGCCTT	0.488													41	85					0	0	0	0	G	29185538	G	G	29185538	3	3	163	1	0	0	0	0	1	0	0	0	10938	709	25	4	306	4	OPRD1	1	29185538	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	15710750	29185538	220065083	4	29509											
HMGB4	127540	broad.mit.edu	37	chr1	34329945	34329945	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcggaaaaatggagatcCatctcaaagcatgaaaaggc	16	8	10	7	1	1	2	1	1	1	1	4	4	2	3	1	3	1	2	1	3	5	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:34329945C>A	uc001bxp.2	+	2	1896	c.153C>A	c.(151-153)TCC>TCA	p.S51S	CSMD2_uc001bxm.1_Intron|CSMD2_uc001bxn.1_Intron|HMGB4_uc001bxq.2_5'UTR	NM_145205	NP_660206	Q8WW32	HMGB4_HUMAN	HMG2 like isoform 1	51						nucleus	DNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AATGGAGATCCATCTCAAAGC	0.403													48	84					1.61863e-15	5.36655e-15	1	0	A	34329945	A	A	34329945	2	1	163	1	0	0	0	0	0	0	0	1	7267	581	21	4		4	HMGB4	1	34329945	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	5144407	34329945	214920676	5	29510											
ZSWIM5	57643	broad.mit.edu	37	chr1	45506091	45506091	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgatgcttgtagatttccaGttgccgctgctgctgcaacc	6	13	10	12	1	0	2	0	1	0	1	1	2	1	2	3	0	6	7	3	0	2	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:45506091G>A	uc001cnd.2	-	7	1957	c.1729C>T	c.(1729-1731)CTG>TTG	p.L577L		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	577							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					TAGATTTCCAGTTGCCGCTGC	0.502													46	46					0	0	0	0	A	45506091	A	A	45506091	2	1	163	1	0	0	0	0	0	0	0	1	18311	1020	36	4		4	ZSWIM5	1	45506091	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	11176146	45506091	203744530	6	29511											
C8A	731	broad.mit.edu	37	chr1	57349196	57349196	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctcagagttttatgataatGcaaatgaccttctttccaaa	13	14	5	9	0	2	3	1	2	1	1	3	3	3	3	3	0	1	2	3	0	4	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:57349196G>T	uc001cyo.2	+	6	829	c.697G>T	c.(697-699)GCA>TCA	p.A233S		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	233	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						TTATGATAATGCAAATGACCT	0.423													14	45					0.000308642	0.000801924	1	0	T	57349196	T	T	57349196	3	4	163	1	0	0	0	0	1	0	0	0	2427	1319	46	4	719	4	C8A	1	57349196	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	11843105	57349196	191901425	7	29512											
DIRAS3	9077	broad.mit.edu	37	chr1	68512915	68512915	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaggcgcggaggataagcagGgcgggcagaagccgcaaccg	12	1	18	10	5	0	1	0	0	0	1	0	3	0	3	2	5	3	3	2	5	4	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:68512915G>A	uc001ded.2	-	2	361	c.66C>T	c.(64-66)GCC>GCT	p.A22A	uc001deb.1_Intron|uc001dec.1_Intron	NM_004675	NP_004666	O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	22					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						GGATAAGCAGGGCGGGCAGAA	0.587													28	38					0	0	0	0	A	68512915	A	A	68512915	2	1	163	1	0	0	0	0	0	0	0	1	4554	1219	43	4		4	DIRAS3	1	68512915	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	11163719	68512915	180737706	8	29513											
PTGER3	5733	broad.mit.edu	37	chr1	71478100	71478100	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagaagttgcattctttcTgcttctccgtgtgtgtcttg	6	17	10	8	1	4	2	0	0	4	2	5	2	4	2	1	0	2	3	1	0	2	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:71478100T>C	uc001dfg.1	-	2	1196	c.965A>G	c.(964-966)CAG>CGG	p.Q322R	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Missense_Mutation_p.Q322R|PTGER3_uc001dfl.1_Missense_Mutation_p.Q322R|PTGER3_uc009wbm.1_Missense_Mutation_p.Q322R|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Missense_Mutation_p.Q322R|PTGER3_uc009wbn.1_Missense_Mutation_p.Q322R|PTGER3_uc009wbo.2_Missense_Mutation_p.Q322R|PTGER3_uc001dfo.2_Missense_Mutation_p.Q322R|PTGER3_uc001dfp.1_Missense_Mutation_p.Q322R|PTGER3_uc001dfq.2_Missense_Mutation_p.Q322R	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	322	Extracellular (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)	GCATTCTTTCTGCTTCTCCGT	0.398													26	33					0	0	0	0	C	71478100	C	C	71478100	3	2	163	1	0	0	0	0	1	0	0	0	12807	1580	55	5	522	5	PTGER3	1	71478100	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	2965185	71478100	177772521	9	29514											
AK5	26289	broad.mit.edu	37	chr1	77752660	77752660	+	Frame_Shift_Del	DEL	A	-	-																															actgatgtgttctaagcccgAagatccagtagaatacttgg																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:77752660delA	uc001dhn.2	+	2	352	c.95delA	c.(94-96)GAAfs	p.E32fs	AK5_uc001dho.2_Frame_Shift_Del_p.E6fs|AK5_uc001dhm.1_Frame_Shift_Del_p.E32fs	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	32					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						TCTAAGCCCGAAGATCCAGTA	0.338													---	---	---								-	77752660	-	-	77752660	7	5	163	1	0	1	0	1	0	0	0	0	443	246	9	0	101	0	AK5	1	77752660	Frame_Shift_Del	DEL	A	TCGA-CR-7398-01A-11D-2012-08	6274560	77752660	171497961	10	29515											
ELTD1	64123	broad.mit.edu	37	chr1	79403499	79403499	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtttcttacctatatcCgttgaatttgtatcaaactc	9	18	4	10	1	2	1	1	1	1	0	4	1	3	1	3	0	2	3	3	0	6	8			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:79403499C>A	uc001diq.3	-	6	909	c.753G>T	c.(751-753)ACG>ACT	p.T251T		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	251	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TACCTATATCCGTTGAATTTG	0.383													34	75					2.20474e-14	7.10952e-14	1	0	A	79403499	A	A	79403499	2	1	163	1	0	0	0	0	0	0	0	1	5108	639	23	3		3	ELTD1	1	79403499	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1650839	79403499	169847122	11	29516											
PRKACB	5567	broad.mit.edu	37	chr1	84668432	84668432	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgaaatggcagctggctatCccccattctttgcagaccaa	11	10	8	12	0	1	2	0	1	1	1	2	2	2	2	3	2	2	4	3	2	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:84668432C>T	uc001djj.2	+	8	973	c.709C>T	c.(709-711)CCC>TCC	p.P237S	PRKACB_uc001djl.2_Missense_Mutation_p.P284S|PRKACB_uc010ort.1_Missense_Mutation_p.P244S|PRKACB_uc001djn.2_Missense_Mutation_p.P241S|PRKACB_uc010oru.1_Missense_Mutation_p.P225S|PRKACB_uc001djp.2_Missense_Mutation_p.P243S|PRKACB_uc001djq.2_Missense_Mutation_p.P207S|PRKACB_uc010orv.1_Missense_Mutation_p.P224S|PRKACB_uc001dji.2_Missense_Mutation_p.P237S|PRKACB_uc001djk.2_Missense_Mutation_p.P284S|PRKACB_uc009wcf.1_Missense_Mutation_p.P243S	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	237	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		AGCTGGCTATCCCCCATTCTT	0.373													39	52					0	0	0	0	T	84668432	T	T	84668432	3	4	163	1	0	0	0	0	1	0	0	0	12560	855	30	2	930	2	PRKACB	1	84668432	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	5264933	84668432	164582189	12	29517											
ABCA4	24	broad.mit.edu	37	chr1	94485286	94485286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggagaaaatcacgcagatgGcaaccacagcatccactgaa	16	5	9	11	1	1	3	1	1	0	2	2	4	2	3	2	2	2	3	2	2	4	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:94485286G>A	uc001dqh.2	-	36	5152	c.5048C>T	c.(5047-5049)GCC>GTC	p.A1683V	ABCA4_uc009wdp.1_5'Flank	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1683	Extracellular.		Missing (in STGD1; highly reduced ATP- binding capacity).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CACGCAGATGGCAACCACAGC	0.383													7	21					0	0	0	0	A	94485286	A	A	94485286	3	1	163	1	0	0	0	0	1	0	0	0	34	1203	42	4	1833	4	ABCA4	1	94485286	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	9816854	94485286	154765335	13	29518											
COL11A1	1301	broad.mit.edu	37	chr1	103440441	103440441	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaggtccttgaggacccTggaaataaaaagcagtgggg	12	7	14	8	0	0	2	0	2	0	0	1	4	1	4	3	5	1	1	3	5	4	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:103440441T>A	uc001dul.2	-	36	3073	c.2755_splice	c.e36-1	p.G919_splice	COL11A1_uc001duk.2_Splice_Site_p.G115_splice|COL11A1_uc001dum.2_Splice_Site_p.G931_splice|COL11A1_uc001dun.2_Splice_Site_p.G880_splice|COL11A1_uc009weh.2_Splice_Site_p.G803_splice	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTGAGGACCCTGGAAATAAAA	0.388													23	28					0	0	0	0	A	103440441	A	A	103440441	5	1	163	1	0	0	0	0	0	0	1	0	3682	1594	55	5	2795	5	COL11A1	1	103440441	Splice_Site	SNP	T	TCGA-CR-7398-01A-11D-2012-08	8955155	103440441	145810180	14	29519											
COL11A1	1301	broad.mit.edu	37	chr1	103444277	103444277	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacgtactctttcacctggaGggccaggagggccatcgcca	8	8	12	13	2	2	0	1	0	1	0	3	2	2	2	4	4	2	1	4	4	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:103444277G>T	uc001dul.2	-	35	3059	c.2741C>A	c.(2740-2742)CCT>CAT	p.P914H	COL11A1_uc001duk.2_Missense_Mutation_p.P110H|COL11A1_uc001dum.2_Missense_Mutation_p.P926H|COL11A1_uc001dun.2_Missense_Mutation_p.P875H|COL11A1_uc009weh.2_Missense_Mutation_p.P798H	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	914	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTCACCTGGAGGGCCAGGAGG	0.378													55	99					8.4772e-36	3.22902e-35	1	0	T	103444277	T	T	103444277	3	4	163	1	0	0	0	0	1	0	0	0	3682	1000	35	4	2811	4	COL11A1	1	103444277	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	3836	103444277	145806344	15	29520											
COL11A1	1301	broad.mit.edu	37	chr1	103461595	103461595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggaccttgtggaccaggggGaccctgaaatagatgaatta	13	8	13	7	0	0	3	0	2	0	1	0	6	0	6	3	4	0	0	3	4	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:103461595G>A	uc001dul.2	-	27	2563	c.2245C>T	c.(2245-2247)CCC>TCC	p.P749S	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.P761S|COL11A1_uc001dun.2_Missense_Mutation_p.P710S|COL11A1_uc009weh.2_Missense_Mutation_p.P633S	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	749	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGACCAGGGGGACCCTGAAAT	0.363													28	46					0	0	0	0	A	103461595	A	A	103461595	3	1	163	1	0	0	0	0	1	0	0	0	3682	1174	41	2	3339	2	COL11A1	1	103461595	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	17318	103461595	145789026	16	29521											
AMY2A	279	broad.mit.edu	37	chr1	104160135	104160135	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaaatacacaacaaggaCggacatctattgttcatctg	14	9	6	12	1	3	0	1	0	2	0	3	2	3	2	2	2	2	1	2	2	5	4	rs145483775	byFrequency	TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:104160135C>T	uc001dut.2	+	1	137	c.73C>T	c.(73-75)CGG>TGG	p.R25W	AMY2A_uc010ouq.1_Missense_Mutation_p.R25W	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	25					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	ACAACAAGGACGGACATCTAT	0.443													64	111					0	0	0	0	T	104160135	T	T	104160135	3	4	163	1	0	0	0	0	1	0	0	0	594	527	19	1	75	1	AMY2A	1	104160135	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	698540	104160135	145090486	17	29522											
KCNA3	3738	broad.mit.edu	37	chr1	111216927	111216927	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgttgaccggccggcggaTgcggcccccggactgatagt	6	6	15	14	6	0	2	0	2	0	0	0	4	0	4	4	5	1	1	4	5	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:111216927T>C	uc001dzv.1	-	1	729	c.505A>G	c.(505-507)ATC>GTC	p.I169V		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	169						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGCCGGCGGATGCGGCCCCCG	0.632													48	68					0	0	0	0	C	111216927	C	C	111216927	3	2	163	1	0	0	0	0	1	0	0	0	8043	1464	51	5	1226	5	KCNA3	1	111216927	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	7056792	111216927	138033694	18	29523											
PDE4DIP	9659	broad.mit.edu	37	chr1	144855862	144855862	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgctgctccgaagctcatGaatacctttgctgcctagca	8	11	10	12	1	1	1	1	1	0	0	2	2	2	1	3	1	7	5	3	1	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:144855862G>C	uc001elw.3	-	41	6982	c.6691C>G	c.(6691-6693)CAT>GAT	p.H2231D	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.H2125D|PDE4DIP_uc001elv.3_Missense_Mutation_p.H1238D	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2231					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CGAAGCTCATGAATACCTTTG	0.567			T	PDGFRB	MPD								4	52					0	0	0	0	C	144855862	C	C	144855862	3	2	163	1	0	0	0	0	1	0	0	0	11697	1290	45	2	365	2	PDE4DIP	1	144855862	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	33638935	144855862	104394759	19	29524											
OTUD7B	56957	broad.mit.edu	37	chr1	149916498	149916498	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcatggcagtcctcagaatgCtcaggctctgcatcacctcc	8	9	9	15	0	4	1	3	0	1	1	6	1	6	1	3	2	2	5	3	2	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:149916498C>T	uc001etn.2	-	12	2146	c.1790G>A	c.(1789-1791)AGC>AAC	p.S597N		NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	597					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			CCTCAGAATGCTCAGGCTCTG	0.557													21	131					0	0	0	0	T	149916498	T	T	149916498	3	4	163	1	0	0	0	0	1	0	0	0	11373	797	28	4	745	4	OTUD7B	1	149916498	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	5060636	149916498	99334123	20	29525											
FLG	2312	broad.mit.edu	37	chr1	152282723	152282723	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccgtctcctgattgttcctCatttcttgtttgcctgcttg	2	19	8	12	1	3	1	1	1	2	0	5	1	4	1	4	0	2	3	4	0	0	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:152282723C>T	uc001ezu.1	-	3	4675	c.4639G>A	c.(4639-4641)GAG>AAG	p.E1547K		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1547	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATTGTTCCTCATTTCTTGTT	0.587									Ichthyosis				168	237					0	0	0	0	T	152282723	T	T	152282723	3	4	163	1	0	0	0	0	1	0	0	0	5954	835	29	2	7550	2	FLG	1	152282723	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2366225	152282723	96967898	21	29526											
LCE2B	26239	broad.mit.edu	37	chr1	152659536	152659536	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggggctggtggctgctgcCtgagccaccacaggccccgt	4	7	15	15	1	0	1	0	1	0	0	0	1	0	1	5	5	3	3	5	5	0	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:152659536C>T	uc001fai.2	+	2	271	c.217C>T	c.(217-219)CTG>TTG	p.L73L		NM_014357	NP_055172	O14633	LCE2B_HUMAN	late cornified envelope 2B	73	Cys-rich.				keratinization					ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCTGCTGCCTGAGCCACCA	0.662													102	119					0	0	0	0	T	152659536	T	T	152659536	2	4	163	1	0	0	0	0	0	0	0	1	8706	680	24	4		4	LCE2B	1	152659536	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	376813	152659536	96591085	22	29527											
FCRL3	115352	broad.mit.edu	37	chr1	157665128	157665128	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttgcttacctgtgacccTgagactcactccatgactgt	8	13	7	13	0	2	3	1	3	1	1	3	4	3	3	3	0	2	1	3	0	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:157665128T>C	uc001frb.2	-	8	1694	c.1402A>G	c.(1402-1404)AGG>GGG	p.R468G	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.R468G|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Missense_Mutation_p.R194G|FCRL3_uc001frc.1_Missense_Mutation_p.R468G	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	468	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CCTGTGACCCTGAGACTCACT	0.488													4	194					0	0	0	0	C	157665128	C	C	157665128	3	2	163	1	0	0	0	0	1	0	0	0	5828	1579	55	5	834	5	FCRL3	1	157665128	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	5005592	157665128	91585493	23	29528											
SPTA1	6708	broad.mit.edu	37	chr1	158595968	158595968	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagagtgaggaagtcaccaaGgtctgcaccattgccattgg	12	8	12	9	0	2	2	1	1	1	1	2	3	2	3	3	3	2	1	3	3	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:158595968G>T	uc001fst.1	-	42	6077	c.5878C>A	c.(5878-5880)CTT>ATT	p.L1960I		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1960	Spectrin 19.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AAGTCACCAAGGTCTGCACCA	0.418													16	29					3.57192e-18	1.20463e-17	1	0	T	158595968	T	T	158595968	3	4	163	1	0	0	0	0	1	0	0	0	15182	1000	35	4	1425	4	SPTA1	1	158595968	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	930840	158595968	90654653	24	29529											
SPTA1	6708	broad.mit.edu	37	chr1	158655028	158655028	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcctcaagcttctgacccCtctcagcgacccgctccttg	7	10	6	18	2	3	1	2	1	2	0	6	2	5	1	5	0	2	2	5	0	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:158655028C>A	uc001fst.1	-	2	333	c.134G>T	c.(133-135)AGG>ATG	p.R45M		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	45	Spectrin 1.		R -> S (in EL2; Clichy).|R -> T (in EL2; Anastasia).		actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					cttctgaccccTCTCAGCGAC	0.323													42	53					3.43241e-23	1.22053e-22	1	0	A	158655028	A	A	158655028	3	1	163	1	0	0	0	0	1	0	0	0	15182	681	24	4	7329	4	SPTA1	1	158655028	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	59060	158655028	90595593	25	29530											
OR6K2	81448	broad.mit.edu	37	chr1	158669657	158669657	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagagtaggtggcagagaaGcgtaggtacatgagagtcac	15	6	15	5	1	1	3	1	1	0	3	1	5	1	3	0	3	2	4	0	3	5	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:158669657G>A	uc001fsu.1	-	1	786	c.786C>T	c.(784-786)CGC>CGT	p.R262R		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TGGCAGAGAAGCGTAGGTACA	0.478													16	32					0	0	0	0	A	158669657	A	A	158669657	2	1	163	1	0	0	0	0	0	0	0	1	11256	958	34	4		4	OR6K2	1	158669657	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	14629	158669657	90580964	26	29531											
ATP1A2	477	broad.mit.edu	37	chr1	160097392	160097392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaccggacggtgatgggcCgcatagctactctcgcctca	8	7	13	13	4	2	2	1	1	1	1	3	4	2	3	3	3	2	2	3	3	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:160097392C>T	uc001fvc.2	+	8	931	c.799C>T	c.(799-801)CGC>TGC	p.R267C	ATP1A2_uc001fvb.2_Missense_Mutation_p.R267C|ATP1A2_uc010piz.1_Missense_Mutation_p.R112C|ATP1A2_uc001fvd.2_Missense_Mutation_p.R3C|ATP1A2_uc009wtg.1_5'Flank	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	267	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GGTGATGGGCCGCATAGCTAC	0.592													31	49					0	0	0	0	T	160097392	T	T	160097392	3	4	163	1	0	0	0	0	1	0	0	0	1131	652	23	1	829	1	ATP1A2	1	160097392	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1427735	160097392	89153229	27	29532											
ILDR2	387597	broad.mit.edu	37	chr1	166927159	166927159	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttgctgagagattgggcccGggtagaggacatgcccaagg	9	7	16	9	1	0	3	0	1	0	2	0	5	0	4	2	4	2	2	2	4	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:166927159G>T	uc001gdx.1	-	2	282	c.226C>A	c.(226-228)CGG>AGG	p.R76R		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	76	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1						GATTGGGCCCGGGTAGAGGAC	0.532													39	71					7.05121e-23	2.49228e-22	1	0	T	166927159	T	T	166927159	2	4	163	1	0	0	0	0	0	0	0	1	7749	1115	39	3		3	ILDR2	1	166927159	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	6829767	166927159	82323462	28	29533											
SELE	6401	broad.mit.edu	37	chr1	169699747	169699747	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcaggggattccagggctgTacagttcacaactgaaaaag	13	8	11	9	0	2	1	2	1	0	0	3	2	3	2	1	3	2	3	1	3	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:169699747T>C	uc001ggm.3	-	5	698	c.541A>G	c.(541-543)ACA>GCA	p.T181A	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	181	Sushi 1.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					TCCAGGGCTGTACAGTTCACA	0.433													22	29					0	0	0	0	C	169699747	C	C	169699747	3	2	163	1	0	0	0	0	1	0	0	0	14078	1638	57	5	1327	5	SELE	1	169699747	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	2772588	169699747	79550874	29	29534											
PAPPA2	60676	broad.mit.edu	37	chr1	176738746	176738746	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aatttctctgtttctagaagGaaattctgctcacatgttct	10	17	6	8	0	5	1	1	0	4	1	6	2	5	2	0	1	1	3	0	1	4	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:176738746G>A	uc001gkz.2	+	16	5491	c.4327G>A	c.(4327-4329)GAA>AAA	p.E1443K	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1443	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTTCTAGAAGGAAATTCTGCT	0.453													13	39					0	0	0	0	A	176738746	A	A	176738746	3	1	163	1	0	0	0	0	1	0	0	0	11487	1175	41	2	4438	2	PAPPA2	1	176738746	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	7038999	176738746	72511875	30	29535											
RNASEL	6041	broad.mit.edu	37	chr1	182551297	182551297	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtccttagtttcctcatctgGagaaagttgaaccacctctt	9	14	7	11	0	3	2	1	1	2	1	5	3	5	2	4	1	1	2	4	1	3	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:182551297G>T	uc001gpj.1	-	3	1830	c.1663C>A	c.(1663-1665)CCA>ACA	p.P555T	RNASEL_uc009wxz.1_Missense_Mutation_p.P555T|RNASEL_uc001gpk.2_Missense_Mutation_p.P555T|RNASEL_uc009wya.1_3'UTR	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	555	Protein kinase.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						tcctcatctggagaaagttga	0.408									Hereditary_Prostate_Cancer				47	110					4.66543e-40	1.79451e-39	1	0	T	182551297	T	T	182551297	3	4	163	1	0	0	0	0	1	0	0	0	13481	1174	41	2	578	2	RNASEL	1	182551297	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	5812551	182551297	66699324	31	29536											
INTS7	25896	broad.mit.edu	37	chr1	212180752	212180752	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtgcatgtgctgtagaatgGgtatcaattttagcttcaag	10	14	12	5	0	2	1	2	0	0	1	2	1	2	1	0	2	3	5	0	2	6	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:212180752G>A	uc001hiw.1	-	6	701	c.596C>T	c.(595-597)CCC>CTC	p.P199L	INTS7_uc009xdb.1_Missense_Mutation_p.P199L|INTS7_uc001hix.1_Missense_Mutation_p.P75L|INTS7_uc001hiy.1_Missense_Mutation_p.P199L|INTS7_uc010pta.1_Missense_Mutation_p.P150L	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	199					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CTGTAGAATGGGTATCAATTT	0.403													6	26					0	0	0	0	A	212180752	A	A	212180752	3	1	163	1	0	0	0	0	1	0	0	0	7822	1232	43	4	2352	4	INTS7	1	212180752	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	29629455	212180752	37069869	32	29537											
USH2A	7399	broad.mit.edu	37	chr1	216040469	216040469	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctcggctcggtgtaaaacCcacactgttgtgtacgaaga	10	11	10	10	3	1	1	0	0	1	1	3	2	1	1	1	2	2	4	1	2	4	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:216040469C>G	uc001hku.1	-	44	9112	c.8725G>C	c.(8725-8727)GGT>CGT	p.G2909R		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2909	Extracellular (Potential).|Fibronectin type-III 15.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGTGTAAAACCCACACTGTTG	0.398										HNSCC(13;0.011)			20	40					0	0	0	0	G	216040469	G	G	216040469	3	3	163	1	0	0	0	0	1	0	0	0	17104	623	22	4	6999	4	USH2A	1	216040469	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	3859717	216040469	33210152	33	29538											
TTC13	79573	broad.mit.edu	37	chr1	231047215	231047215	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	taatgacaggatattacttaCctggatcctcgagagagtgg	12	11	11	7	1	0	2	0	1	0	1	2	6	1	4	2	3	2	0	2	3	4	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:231047215C>T	uc001huf.3	-	20	2340	c.2309_splice	c.e20+1	p.S770_splice	TTC13_uc009xfi.2_Splice_Site_p.S717_splice|TTC13_uc009xfj.2_Splice_Site|TTC13_uc001hug.3_Splice_Site_p.S716_splice|TTC13_uc009xfk.1_Splice_Site_p.S659_splice	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a								binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		ATATTACTTACCTGGATCCTC	0.313													8	14					0	0	0	0	T	231047215	T	T	231047215	5	4	163	1	0	0	0	0	0	0	1	0	16748	521	18	4	288	4	TTC13	1	231047215	Splice_Site	SNP	C	TCGA-CR-7398-01A-11D-2012-08	15006746	231047215	18203406	34	29539											
RYR2	6262	broad.mit.edu	37	chr1	237942010	237942010	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttggcacacagcaggctGtgggatgctgtggtcggctt	6	11	16	8	1	0	0	0	0	0	0	1	1	0	1	0	5	2	6	0	5	0	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:237942010G>T	uc001hyl.1	+	88	11940	c.11820G>T	c.(11818-11820)CTG>CTT	p.L3940L	RYR2_uc010pya.1_Silent_p.L355L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3940	Helical; Name=M1; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACAGCAGGCTGTGGGATGCTG	0.443													27	43					3.57733e-08	1.02947e-07	1	0	T	237942010	T	T	237942010	2	4	163	1	0	0	0	0	0	0	0	1	13834	1364	48	4		4	RYR2	1	237942010	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	6894795	237942010	11308611	35	29540											
VN1R5	317705	broad.mit.edu	37	chr1	247419676	247419676	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttcacccaggcaatattGgtgtccttagacttctttgg	7	15	8	11	0	3	1	1	0	2	1	4	1	4	1	2	3	0	1	2	3	3	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:247419676G>T	uc010pyu.1	+	2	303	c.303G>T	c.(301-303)TTG>TTT	p.L101F		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	101	Helical; Name=3; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			AGGCAATATTGGTGTCCTTAG	0.423													73	86					9.07738e-34	3.4354e-33	1	0	T	247419676	T	T	247419676	3	4	163	1	0	0	0	0	1	0	0	0	17249	1339	47	4	305	4	VN1R5	1	247419676	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	9477666	247419676	1830945	36	29541											
NLRP3	114548	broad.mit.edu	37	chr1	247599293	247599293	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtcagctgctgcctcacAtcagcatgttgtcaggatct	7	13	10	11	0	5	0	4	0	1	0	5	1	5	1	1	2	4	4	1	2	0	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:247599293A>G	uc001icr.2	+	8	2658	c.2520A>G	c.(2518-2520)ACA>ACG	p.T840T	NLRP3_uc001ics.2_Intron|NLRP3_uc001icu.2_Silent_p.T840T|NLRP3_uc001icw.2_Silent_p.T783T|NLRP3_uc001icv.2_Intron|NLRP3_uc010pyw.1_Silent_p.T818T	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	840	LRR 4.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCTGCCTCACATCAGCATGTT	0.537													22	48					0	0	0	0	G	247599293	G	G	247599293	2	3	163	1	0	0	0	0	0	0	0	1	10532	204	8	5		5	NLRP3	1	247599293	Silent	SNP	A	TCGA-CR-7398-01A-11D-2012-08	179617	247599293	1651328	37	29542											
OR11L1	391189	broad.mit.edu	37	chr1	248004498	248004499	+	Frame_Shift_Ins	INS	-	A	A																															tgtggaaaaggtctttctccINSggccagaggtggaagggatt																								rs147783465	byFrequency	TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:248004498_248004499insA	uc001idn.1	-	1	700_701	c.700_701insT	c.(700-702)CGGfs	p.R234fs		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGTCTTTCTCCGGCCAGAGGTG	0.505													---	---	---								A	248004499	A	A	248004498	7	5	163	1	0	1	1	0	0	0	0	0	10984	652	23	0	271	0	OR11L1	1	248004498	Frame_Shift_Ins	INS	-	TCGA-CR-7398-01A-11D-2012-08	405205	248004498	1246123	38	29543											
OR14C36	127066	broad.mit.edu	37	chr1	248512790	248512790	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacaaaggccttttccacCtgcatccctcacatcctggt	10	10	6	15	0	1	1	1	0	0	1	4	1	4	1	5	2	2	1	5	2	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr1:248512790C>G	uc010pzl.1	+	1	714	c.714C>G	c.(712-714)ACC>ACG	p.T238T		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CCTTTTCCACCTGCATCCCTC	0.522													34	48					0	0	0	0	G	248512790	G	G	248512790	2	3	163	1	0	0	0	0	0	0	0	1	11000	668	24	4		4	OR14C36	1	248512790	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	508292	248512790	737831	39	29544											
NBAS	51594	broad.mit.edu	37	chr2	15679480	15679480	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggggtttcgggtctttcggaActagaacaaaagaaaacaag	15	8	12	6	2	1	2	0	0	1	2	3	3	1	3	0	4	3	1	0	4	8	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:15679480A>T	uc002rcc.1	-	7	406	c.380T>A	c.(379-381)GTT>GAT	p.V127D	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	127										ovary(2)|liver(1)|skin(1)	4						GTCTTTCGGAACTAGAACAAA	0.398													5	39					0	0	0	0	T	15679480	T	T	15679480	3	4	163	1	0	0	0	0	1	0	0	0	10239	57	2	5	6919	5	NBAS	2	15679480	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08		15679480	227519893	40	29545											
CIB4	130106	broad.mit.edu	37	chr2	26852280	26852280	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaccatcctggactcacccGcagagctggcagggagctga	9	5	12	15	1	1	2	1	1	0	1	2	4	2	4	4	3	2	4	4	3	0	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:26852280G>T	uc002rhm.2	-	3	213	c.184C>A	c.(184-186)CGG>AGG	p.R62R		NM_001029881	NP_001025052	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	62	EF-hand 1.						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGACTCACCCGCAGAGCTGGC	0.622													4	9					0.000602214	0.00155782	1	0	T	26852280	T	T	26852280	2	4	163	1	0	0	0	0	0	0	0	1	3438	1086	38	3		3	CIB4	2	26852280	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	11172800	26852280	216347093	41	29546											
KHK	3795	broad.mit.edu	37	chr2	27322328	27322328	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgaggagggcgccgacGccctgggccctgatggcaaa	7	4	18	12	3	0	2	0	2	0	0	0	4	0	3	3	5	0	2	3	5	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:27322328G>T	uc002ril.2	+	7	1211	c.694G>T	c.(694-696)GCC>TCC	p.A232S	KHK_uc002rim.2_Missense_Mutation_p.A232S|KHK_uc002rin.2_Missense_Mutation_p.A233S|KHK_uc002rio.2_Missense_Mutation_p.A148S|CGREF1_uc010ylf.1_3'UTR|CGREF1_uc002rip.1_3'UTR	NM_000221	NP_000212	P50053	KHK_HUMAN	ketohexokinase isoform a	232					fructose catabolic process	cytosol	ATP binding|ketohexokinase activity|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGCGCCGACGCCCTGGGCCC	0.652													17	70					1.56452e-12	4.97688e-12	1	0	T	27322328	T	T	27322328	3	4	163	1	0	0	0	0	1	0	0	0	8188	1087	38	3	859	3	KHK	2	27322328	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	470048	27322328	215877045	42	29547											
SNX17	9784	broad.mit.edu	37	chr2	27596131	27596131	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagttcggcaagacccattgCttgggagcagcgagactttc	9	10	12	10	2	0	2	0	0	0	2	2	4	0	3	1	2	3	4	1	2	2	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:27596131C>A	uc002rkg.1	+	4	496	c.274C>A	c.(274-276)CTT>ATT	p.L92I	EIF2B4_uc002rka.2_5'Flank|EIF2B4_uc002rkb.2_5'Flank|EIF2B4_uc002rkc.2_5'Flank|EIF2B4_uc002rkd.2_5'Flank|EIF2B4_uc002rke.2_5'Flank|EIF2B4_uc002rkf.1_5'Flank|SNX17_uc010ylj.1_Missense_Mutation_p.L72I|SNX17_uc010ylk.1_5'UTR|SNX17_uc010eza.1_5'UTR|SNX17_uc002rki.1_RNA|SNX17_uc002rkh.1_5'UTR|SNX17_uc010yll.1_5'UTR|SNX17_uc010ylm.1_5'UTR|SNX17_uc010yln.1_Missense_Mutation_p.L80I|SNX17_uc010ylo.1_Missense_Mutation_p.L10I|SNX17_uc010ylp.1_Missense_Mutation_p.L67I|SNX17_uc010ylq.1_5'UTR	NM_014748	NP_055563	Q15036	SNX17_HUMAN	sorting nexin 17	92	PX.				cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGACCCATTGCTTGGGAGCAG	0.527													17	68					0.000958276	0.00246264	1	0	A	27596131	A	A	27596131	3	1	163	1	0	0	0	0	1	0	0	0	14952	797	28	4	288	4	SNX17	2	27596131	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	273803	27596131	215603242	43	29548											
SLC4A1AP	22950	broad.mit.edu	37	chr2	27898488	27898488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgataggactggcctgattGagaagaagcgtctgaacaga	13	9	13	6	1	1	6	0	4	1	3	1	8	1	7	1	2	2	0	1	2	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:27898488G>A	uc002rlk.3	+	6	1717	c.1435G>A	c.(1435-1437)GAG>AAG	p.E479K		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	479						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					TGGCCTGATTGAGAAGAAGCG	0.413													12	36					0	0	0	0	A	27898488	A	A	27898488	3	1	163	1	0	0	0	0	1	0	0	0	14717	1291	45	2	1457	2	SLC4A1AP	2	27898488	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	302357	27898488	215300885	44	29549											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48873734	48873734	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgttccacaattgaatccAtggtctcttcaagcaactac	12	12	6	11	0	2	1	1	1	1	0	5	1	4	1	2	1	3	2	2	1	5	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:48873734A>G	uc010yol.1	+	5	2549	c.2502A>G	c.(2500-2502)CCA>CCG	p.P834P	STON1-GTF2A1L_uc002rwp.1_Silent_p.P881P|GTF2A1L_uc002rws.1_Silent_p.P177P|GTF2A1L_uc010yom.1_Silent_p.P143P|GTF2A1L_uc002rwt.2_Silent_p.P177P	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	834					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AATTGAATCCATGGTCTCTTC	0.428													39	32					0	0	0	0	G	48873734	G	G	48873734	2	3	163	1	0	0	0	0	0	0	0	1	15383	204	8	5		5	STON1-GTF2A1L	2	48873734	Silent	SNP	A	TCGA-CR-7398-01A-11D-2012-08	20975246	48873734	194325639	45	29550											
FAM136A	84908	broad.mit.edu	37	chr2	70527991	70527991	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggaacttctccagctcaCtggtgaccaaagcctgggct	8	9	10	14	0	2	1	1	1	1	0	3	2	2	2	4	3	3	2	4	3	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:70527991C>T	uc002sgq.3	-	2	286	c.209G>A	c.(208-210)AGT>AAT	p.S70N	FAM136A_uc010fdp.2_RNA	NM_032822	NP_116211	Q96C01	F136A_HUMAN	hypothetical protein LOC84908	70						mitochondrion	protein binding				0						CTCCAGCTCACTGGTGACCAA	0.522													65	145					0	0	0	0	T	70527991	T	T	70527991	3	4	163	1	0	0	0	0	1	0	0	0	5478	565	20	4	215	4	FAM136A	2	70527991	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	21654257	70527991	172671382	46	29551											
DYSF	8291	broad.mit.edu	37	chr2	71909661	71909661	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgggatctcgcttccaggCgccccgacacctccttcctg	4	9	9	19	4	1	0	0	0	1	0	6	2	5	1	7	2	0	1	7	2	0	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:71909661C>A	uc002sie.2	+	54	6434	c.6058C>A	c.(6058-6060)CGC>AGC	p.R2020S	DYSF_uc010feg.2_Missense_Mutation_p.R2051S|DYSF_uc010feh.2_Missense_Mutation_p.R2027S|DYSF_uc002sig.3_Missense_Mutation_p.R2006S|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R2041S|DYSF_uc010fef.2_Missense_Mutation_p.R2058S|DYSF_uc010fei.2_Missense_Mutation_p.R2037S|DYSF_uc010fek.2_Missense_Mutation_p.R2038S|DYSF_uc010fej.2_Missense_Mutation_p.R2028S|DYSF_uc010fel.2_Missense_Mutation_p.R2007S|DYSF_uc010feo.2_Missense_Mutation_p.R2052S|DYSF_uc010fem.2_Missense_Mutation_p.R2042S|DYSF_uc010fen.2_Missense_Mutation_p.R2059S|DYSF_uc002sif.2_Missense_Mutation_p.R2021S|DYSF_uc010yqy.1_Missense_Mutation_p.R901S|DYSF_uc010yqz.1_Missense_Mutation_p.R781S	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	2020	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CGCTTCCAGGCGCCCCGACAC	0.522													34	99					1.71298e-08	4.96595e-08	1	0	A	71909661	A	A	71909661	3	1	163	1	0	0	0	0	1	0	0	0	4881	782	27	3	6531	3	DYSF	2	71909661	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1381670	71909661	171289712	47	29552											
SLC4A5	57835	broad.mit.edu	37	chr2	74452068	74452068	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtcaatccaggccaggtCgtgctgggaaaagatgaaat	12	9	13	7	1	1	2	1	1	0	1	3	3	2	3	2	3	1	2	2	3	4	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:74452068C>A	uc002sko.1	-	24	3195	c.3193G>T	c.(3193-3195)GAC>TAC	p.D1065Y	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.D1049Y|SLC4A5_uc010ffc.1_Missense_Mutation_p.D968Y|SLC4A5_uc002skp.1_Missense_Mutation_p.D947Y|SLC4A5_uc002sks.1_Silent_p.T956T	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	1065	Extracellular (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						CAGGCCAGGTCGTGCTGGGAA	0.473													36	95					2.04263e-09	6.18041e-09	1	0	A	74452068	A	A	74452068	3	1	163	1	0	0	0	0	1	0	0	0	14721	884	31	3	232	3	SLC4A5	2	74452068	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2542407	74452068	168747305	48	29553											
FAM176A	84141	broad.mit.edu	37	chr2	75745218	75745218	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccgctaggatgttgctgaGcaaagccatctccacgtgct	8	9	12	12	2	1	1	0	1	1	0	2	2	1	2	3	2	4	5	3	2	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:75745218G>T	uc002sni.2	-	3	527	c.49C>A	c.(49-51)CTC>ATC	p.L17I	FAM176A_uc002snj.1_Missense_Mutation_p.L4I|FAM176A_uc002snk.1_Missense_Mutation_p.L17I	NM_001135032	NP_001128504	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	17	Necessary for the localization and biological activity.				apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0						ATGTTGCTGAGCAAAGCCATC	0.602													40	33					5.48756e-27	2.01211e-26	1	0	T	75745218	T	T	75745218	3	4	163	1	0	0	0	0	1	0	0	0	5527	971	34	4	417	4	FAM176A	2	75745218	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1293150	75745218	167454155	49	29554											
CTNNA2	1496	broad.mit.edu	37	chr2	80846291	80846291	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagggctagtcaactttctAcccacctcccaacctgtgct	8	10	7	16	0	2	0	1	0	1	0	3	0	3	0	4	1	4	3	4	1	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:80846291A>T	uc010ysh.1	+	17	2517	c.2512A>T	c.(2512-2514)ACC>TCC	p.T838S	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysi.1_Intron|CTNNA2_uc010ysj.1_Intron	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	838					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TCAACTTTCTACCCACCTCCC	0.443													8	6					0	0	0	0	T	80846291	T	T	80846291	3	4	163	1	0	0	0	0	1	0	0	0	4030	406	14	5		5	CTNNA2	2	80846291	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	5101073	80846291	162353082	50	29555											
GPR45	11250	broad.mit.edu	37	chr2	105858978	105858978	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacatgtgcatcctcaacacGgtccgcaagaacgccgtgcg	10	7	10	14	5	1	1	1	0	0	1	3	1	3	1	3	1	5	2	3	1	4	1	rs141451236		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:105858978G>A	uc002tco.1	+	1	779	c.663G>A	c.(661-663)ACG>ACA	p.T221T		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	221	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TCCTCAACACGGTCCGCAAGA	0.677													29	56					0	0	0	0	A	105858978	A	A	105858978	2	1	163	1	0	0	0	0	0	0	0	1	6734	1103	39	1		1	GPR45	2	105858978	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	25012687	105858978	137340395	51	29556											
MERTK	10461	broad.mit.edu	37	chr2	112754924	112754924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtagattatgccccctcttCaactccggcgcctggcaacg	7	9	10	15	3	2	1	1	0	1	1	3	1	3	1	4	3	3	2	4	3	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:112754924C>T	uc002thk.1	+	10	1597	c.1475C>T	c.(1474-1476)TCA>TTA	p.S492L	MERTK_uc002thl.1_Missense_Mutation_p.S316L	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	492	Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GCCCCCTCTTCAACTCCGGCG	0.443													87	165					0	0	0	0	T	112754924	T	T	112754924	3	4	163	1	0	0	0	0	1	0	0	0	9532	838	29	2	1513	2	MERTK	2	112754924	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	6895946	112754924	130444449	52	29557											
DPP10	57628	broad.mit.edu	37	chr2	116534814	116534814	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaattaccgtgcggcatCtgacatcaggaaactgggaa	14	7	11	9	2	2	1	1	1	1	0	2	3	2	3	1	3	4	2	1	3	4	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:116534814C>A	uc002tla.1	+	14	1709	c.1252C>A	c.(1252-1254)CTG>ATG	p.L418M	DPP10_uc002tlb.1_Missense_Mutation_p.L368M|DPP10_uc002tlc.1_Missense_Mutation_p.L414M|DPP10_uc002tle.2_Missense_Mutation_p.L422M|DPP10_uc002tlf.1_Missense_Mutation_p.L411M	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	418	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CGTGCGGCATCTGACATCAGG	0.378													9	20					3.86212e-05	0.000102612	1	0	A	116534814	A	A	116534814	3	1	163	1	0	0	0	0	1	0	0	0	4749	912	32	2	1477	2	DPP10	2	116534814	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	3779890	116534814	126664559	53	29558											
DDX18	8886	broad.mit.edu	37	chr2	118582663	118582663	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaactacattgatttgcccGtcttggccattcatgtaagt	9	15	8	9	1	2	2	1	2	1	0	2	2	2	2	2	1	3	1	2	1	3	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:118582663G>T	uc002tlh.1	+	9	1453	c.1354G>T	c.(1354-1356)GTC>TTC	p.V452F		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	452	Helicase C-terminal.						ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						TGATTTGCCCGTCTTGGCCAT	0.388													48	70					2.13883e-14	6.91594e-14	1	0	T	118582663	T	T	118582663	3	4	163	1	0	0	0	0	1	0	0	0	4362	1145	40	3	1388	3	DDX18	2	118582663	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2047849	118582663	124616710	54	29559											
YSK4	80122	broad.mit.edu	37	chr2	135739048	135739048	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatccaaagccacctgttttAcagctattagctgtccttga	10	14	6	11	0	0	1	0	1	0	0	2	1	2	1	4	0	4	3	4	0	5	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:135739048A>G	uc002tue.1	-	9	3294	c.3263T>C	c.(3262-3264)GTA>GCA	p.V1088A	YSK4_uc002tuf.1_Missense_Mutation_p.V270A|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.V975A|YSK4_uc010zbg.1_Missense_Mutation_p.V220A|YSK4_uc002tuh.3_Missense_Mutation_p.V816A|YSK4_uc002tui.3_3'UTR	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1088	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CACCTGTTTTACAGCTATTAG	0.353													33	49					0	0	0	0	G	135739048	G	G	135739048	3	3	163	1	0	0	0	0	1	0	0	0	17563	391	14	5	731	5	YSK4	2	135739048	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	17156385	135739048	107460325	55	29560											
LRP1B	53353	broad.mit.edu	37	chr2	141816540	141816540	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atatcagtcccattaaatcgGtttatccttacgatattgta	12	16	5	8	2	1	0	1	0	0	0	4	1	3	0	2	1	1	2	2	1	7	8			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:141816540G>T	uc002tvj.1	-	9	2292	c.1320C>A	c.(1318-1320)AAC>AAA	p.N440K	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	440	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATTAAATCGGTTTATCCTTA	0.323										TSP Lung(27;0.18)			23	58					1.55795e-14	5.05152e-14	1	0	T	141816540	T	T	141816540	3	4	163	1	0	0	0	0	1	0	0	0	9005	1252	44	4	12811	4	LRP1B	2	141816540	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	6077492	141816540	101382833	56	29561											
CYTIP	9595	broad.mit.edu	37	chr2	158272457	158272457	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgccgactgaaggcacccCtgctggagtcctcagacaca	9	7	10	15	1	2	2	1	1	1	1	3	4	3	3	4	2	2	2	4	2	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:158272457C>A	uc002tzj.1	-	8	884	c.812G>T	c.(811-813)AGG>ATG	p.R271M	CYTIP_uc010zcl.1_Missense_Mutation_p.R165M	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	271	Ser-rich.				regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						GAAGGCACCCCTGCTGGAGTC	0.532													23	48					2.98393e-07	8.36211e-07	1	0	A	158272457	A	A	158272457	3	1	163	1	0	0	0	0	1	0	0	0	4224	681	24	4	271	4	CYTIP	2	158272457	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	16455917	158272457	84926916	57	29562											
SLC4A10	57282	broad.mit.edu	37	chr2	162761344	162761344	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatagcctattctctctttgGtggacagcctcttaccatat	8	15	7	11	0	3	0	0	0	3	0	4	2	3	1	3	2	3	0	3	2	4	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:162761344G>T	uc002ubx.3	+	14	1860	c.1676G>T	c.(1675-1677)GGT>GTT	p.G559V	SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.G529V|SLC4A10_uc010zcs.1_Missense_Mutation_p.G540V	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	559	Helical; (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TCTCTCTTTGGTGGACAGCCT	0.393													47	62					2.55665e-31	9.61397e-31	1	0	T	162761344	T	T	162761344	3	4	163	1	0	0	0	0	1	0	0	0	14715	1261	44	4	1815	4	SLC4A10	2	162761344	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	4488887	162761344	80438029	58	29563											
KCNH7	90134	broad.mit.edu	37	chr2	163292054	163292054	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatccagtttcctggccacGcgcacaagacggaggagtcg	9	6	13	13	5	0	1	0	0	0	1	3	4	2	3	3	3	0	2	3	3	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:163292054G>T	uc002uch.1	-	8	1820	c.1608C>A	c.(1606-1608)CGC>CGA	p.R536R	KCNH7_uc002uci.2_Silent_p.R529R	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	536	Helical; Voltage-sensor; Name=Segment S4; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TCCTGGCCACGCGCACAAGAC	0.453													18	24					3.52763e-06	9.61116e-06	1	0	T	163292054	T	T	163292054	2	4	163	1	0	0	0	0	0	0	0	1	8076	1074	38	3		3	KCNH7	2	163292054	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	530710	163292054	79907319	59	29564											
SCN3A	6328	broad.mit.edu	37	chr2	165947639	165947639	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttttaacataggcaaagttgGacatcccaaagatggcatag	15	10	9	7	0	0	1	0	0	0	1	1	2	1	2	1	3	1	3	1	3	5	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:165947639G>C	uc002ucx.2	-	28	5516	c.5024C>G	c.(5023-5025)TCC>TGC	p.S1675C	SCN3A_uc010zcy.1_Missense_Mutation_p.S158C|SCN3A_uc002ucy.2_Missense_Mutation_p.S1626C|SCN3A_uc002ucz.2_Missense_Mutation_p.S1626C	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1675	Helical; Name=S5 of repeat IV; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GGCAAAGTTGGACATCCCAAA	0.443													67	99					0	0	0	0	C	165947639	C	C	165947639	3	2	163	1	0	0	0	0	1	0	0	0	13983	1174	41	2	982	2	SCN3A	2	165947639	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2655585	165947639	77251734	60	29565											
XIRP2	129446	broad.mit.edu	37	chr2	168106105	168106105	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctatgaaagtcataaacagCaatctgagattgatgttcaa	16	11	8	6	0	3	3	2	3	1	1	3	4	3	3	0	0	2	3	0	0	6	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:168106105C>A	uc002udx.2	+	8	8221	c.8203C>A	c.(8203-8205)CAA>AAA	p.Q2735K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.Q2560K|XIRP2_uc010fpq.2_Missense_Mutation_p.Q2513K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.Q81K	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2560					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCATAAACAGCAATCTGAGAT	0.343													21	39					2.4624e-09	7.39347e-09	1	0	A	168106105	A	A	168106105	3	1	163	1	0	0	0	0	1	0	0	0	17498	711	25	4	8233	4	XIRP2	2	168106105	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2158466	168106105	75093268	61	29566											
LRP2	4036	broad.mit.edu	37	chr2	170055350	170055350	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtcattgtctccgtcacAcaaataaacgcgaggaatac	15	8	7	11	3	3	0	2	0	1	0	4	2	3	1	1	1	2	0	1	1	5	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:170055350A>G	uc002ues.2	-	45	8737	c.8524T>C	c.(8524-8526)TGT>CGT	p.C2842R		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2842	LDL-receptor class A 19.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCTCCGTCACACAAATAAACG	0.368													12	28					0	0	0	0	G	170055350	G	G	170055350	3	3	163	1	0	0	0	0	1	0	0	0	9006	159	6	5	5583	5	LRP2	2	170055350	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	1949245	170055350	73144023	62	29567											
LRP2	4036	broad.mit.edu	37	chr2	170058313	170058313	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcattgtagtaatcacaGcggtaagagtattggacaca	14	10	10	7	1	2	1	2	0	0	1	2	2	2	2	0	2	1	4	0	2	4	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:170058313G>T	uc002ues.2	-	44	8490	c.8277C>A	c.(8275-8277)CGC>CGA	p.R2759R		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2759	Extracellular (Potential).|LDL-receptor class A 17.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGTAATCACAGCGGTAAGAGT	0.498													17	39					3.45872e-05	9.2102e-05	1	0	T	170058313	T	T	170058313	2	4	163	1	0	0	0	0	0	0	0	1	9006	958	34	4		4	LRP2	2	170058313	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2963	170058313	73141060	63	29568											
TTN	7273	broad.mit.edu	37	chr2	179614488	179614488	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccttaatatataattggtgGctacaattaacttcttcaaa	14	16	4	7	0	2	0	1	0	1	0	3	0	3	0	1	2	2	1	1	2	8	9			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:179614488G>T	uc002unb.2	-	46	12863	c.12639C>A	c.(12637-12639)AGC>AGA	p.S4213R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAATTGGTGGCTACAATTAA	0.348													14	29					7.93312e-07	2.19701e-06	1	0	T	179614488	T	T	179614488	3	4	163	1	0	0	0	0	1	0	0	0	16803	1194	42	4	97658	4	TTN	2	179614488	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	9556175	179614488	63584885	64	29569											
TTN	7273	broad.mit.edu	37	chr2	179659867	179659867	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccctcttgcttccaaggggGaggcacttcaggacctgtgg	6	9	14	12	0	2	0	1	0	1	0	3	2	3	2	3	5	1	2	3	5	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:179659867G>T	uc010zfg.1	-	7	1251	c.1027C>A	c.(1027-1029)CCC>ACC	p.P343T	TTN_uc010zfh.1_Missense_Mutation_p.P343T|TTN_uc010zfi.1_Missense_Mutation_p.P343T|TTN_uc010zfj.1_Missense_Mutation_p.P343T|TTN_uc002unb.2_Missense_Mutation_p.P343T|TTN_uc010frg.1_Missense_Mutation_p.P17T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	343							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCAAGGGGGAGGCACTTCA	0.547													30	46					1.38854e-25	5.02865e-25	1	0	T	179659867	T	T	179659867	3	4	163	1	0	0	0	0	1	0	0	0	16803	1174	41	2	110385	2	TTN	2	179659867	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	45379	179659867	63539506	65	29570											
SSFA2	6744	broad.mit.edu	37	chr2	182783380	182783380	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccatatagtactcagaaatCatctgttctacctctttatg	11	16	4	10	0	5	1	2	0	3	1	6	1	6	1	2	0	2	2	2	0	6	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:182783380C>G	uc002uoi.2	+	12	3165	c.2843C>G	c.(2842-2844)TCA>TGA	p.S948*	SSFA2_uc002uoh.2_Nonsense_Mutation_p.S948*|SSFA2_uc002uoj.2_Nonsense_Mutation_p.S948*|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Nonsense_Mutation_p.S795*|SSFA2_uc002uol.2_Nonsense_Mutation_p.S795*|SSFA2_uc002uom.2_Nonsense_Mutation_p.S416*	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	948						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			ACTCAGAAATCATCTGTTCTA	0.313													30	46					0	0	0	0	G	182783380	G	G	182783380	4	3	163	1	0	0	0	0	0	1	0	0	15249	838	29	2	2889	2	SSFA2	2	182783380	Nonsense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	3123513	182783380	60415993	66	29571											
NCKAP1	10787	broad.mit.edu	37	chr2	183818048	183818048	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgattatacatagtcatcCcaacaattgacctgggaaga	14	11	7	9	0	1	3	1	2	0	1	2	4	2	4	2	1	2	0	2	1	6	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:183818048C>A	uc002upc.2	-	21	2567	c.2165G>T	c.(2164-2166)GGG>GTG	p.G722V	NCKAP1_uc002upb.2_Missense_Mutation_p.G728V	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	722					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CATAGTCATCCCAACAATTGA	0.363													15	27					4.7546e-09	1.40255e-08	1	0	A	183818048	A	A	183818048	3	1	163	1	0	0	0	0	1	0	0	0	10275	623	22	4	1265	4	NCKAP1	2	183818048	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1034668	183818048	59381325	67	29572											
COL5A2	1290	broad.mit.edu	37	chr2	189909940	189909940	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagctcgaccaggtggtcCtataggaccccgagaaccct	9	6	10	16	2	0	1	0	0	0	1	2	4	1	2	6	3	2	1	6	3	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:189909940C>A	uc002uqk.2	-	47	3603	c.3328G>T	c.(3328-3330)GGA>TGA	p.G1110*	COL5A2_uc010frx.2_Nonsense_Mutation_p.G686*	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1110					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAGGTGGTCCTATAGGACCC	0.323													12	17					2.62699e-14	8.44799e-14	1	0	A	189909940	A	A	189909940	4	1	163	1	0	0	0	0	0	1	0	0	3712	690	24	4	1203	4	COL5A2	2	189909940	Nonsense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	6091892	189909940	53289433	68	29573											
SDPR	8436	broad.mit.edu	37	chr2	192701281	192701281	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttttcctcggcactgtcttCcagggcctcctcatcgtggg	3	13	10	15	2	2	0	1	0	1	0	7	0	5	0	4	3	0	1	4	3	0	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:192701281C>G	uc002utb.2	-	2	976	c.646G>C	c.(646-648)GAA>CAA	p.E216Q		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	216	Potential.					caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GCACTGTCTTCCAGGGCCTCC	0.502													47	79					0	0	0	0	G	192701281	G	G	192701281	3	3	163	1	0	0	0	0	1	0	0	0	14035	864	30	2	635	2	SDPR	2	192701281	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2791341	192701281	50498092	69	29574											
AOX1	316	broad.mit.edu	37	chr2	201476122	201476122	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacagaaggaaaacgacagaTtcctttaaatgagcaattcc	17	8	7	9	1	0	3	0	1	0	2	2	5	2	4	2	1	2	1	2	1	6	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:201476122T>C	uc002uvx.2	+	13	1270	c.1169T>C	c.(1168-1170)ATT>ACT	p.I390T	AOX1_uc010zhf.1_Intron|AOX1_uc010fsu.2_Intron	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	390	FAD-binding PCMH-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	AAACGACAGATTCCTTTAAAT	0.398													68	102					0	0	0	0	C	201476122	C	C	201476122	3	2	163	1	0	0	0	0	1	0	0	0	729	1493	52	5	1219	5	AOX1	2	201476122	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	8774841	201476122	41723251	70	29575											
AOX1	316	broad.mit.edu	37	chr2	201507394	201507394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtttcccaatctccgctgccGgggttgggcatgcagaacca	7	9	12	13	2	1	1	0	0	1	1	3	1	2	1	4	3	3	5	4	3	2	2	rs139407288		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:201507394G>A	uc002uvx.2	+	25	2818	c.2717G>A	c.(2716-2718)CGG>CAG	p.R906Q	AOX1_uc010zhf.1_Missense_Mutation_p.R462Q|AOX1_uc010fsu.2_Missense_Mutation_p.R272Q	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	906					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CTCCGCTGCCGGGGTTGGGCA	0.473													22	37					0	0	0	0	A	201507394	A	A	201507394	3	1	163	1	0	0	0	0	1	0	0	0	729	1116	39	1	2815	1	AOX1	2	201507394	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	31272	201507394	41691979	71	29576											
PTH2R	5746	broad.mit.edu	37	chr2	209308142	209308142	+	Frame_Shift_Del	DEL	C	-	-																															ttcatgctgagagctacaagCatctttgtcaaagacagagt																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:209308142delC	uc002vdb.2	+	6	792	c.579delC	c.(577-579)AGCfs	p.S193fs	PTH2R_uc010zjb.1_Frame_Shift_Del_p.S204fs	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	193	Helical; Name=2; (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		GAGCTACAAGCATCTTTGTCA	0.398													---	---	---								-	209308142	-	-	209308142	7	5	163	1	0	1	0	1	0	0	0	0	12823	709	25	0	601	0	PTH2R	2	209308142	Frame_Shift_Del	DEL	C	TCGA-CR-7398-01A-11D-2012-08	7800748	209308142	33891231	72	29577											
MAP2	4133	broad.mit.edu	37	chr2	210545497	210545497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgaagaaacagctaatctgCctccttctccacccccatca	11	9	4	17	0	3	2	1	1	2	1	5	2	4	2	5	0	3	1	5	0	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:210545497C>T	uc002vde.1	+	6	648	c.400C>T	c.(400-402)CCT>TCT	p.P134S	MAP2_uc002vdc.1_Missense_Mutation_p.P134S|MAP2_uc002vdd.1_Missense_Mutation_p.P134S|MAP2_uc002vdf.1_Missense_Mutation_p.P134S|MAP2_uc002vdg.1_Missense_Mutation_p.P134S|MAP2_uc002vdh.1_Missense_Mutation_p.P134S|MAP2_uc002vdi.1_Missense_Mutation_p.P134S	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	134					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGCTAATCTGCCTCCTTCTCC	0.433													88	147					0	0	0	0	T	210545497	T	T	210545497	3	4	163	1	0	0	0	0	1	0	0	0	9288	739	26	4	410	4	MAP2	2	210545497	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1237355	210545497	32653876	73	29578											
ACADL	33	broad.mit.edu	37	chr2	211057583	211057583	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatggagctgtacacagtCgtaagctacactattttgta	11	13	8	9	1	0	0	0	0	0	0	2	1	1	1	1	1	4	5	1	1	5	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:211057583C>A	uc002vdz.3	-	10	1372	c.1144G>T	c.(1144-1146)GAC>TAC	p.D382Y		NM_001608	NP_001599	P28330	ACADL_HUMAN	long-chain acyl-CoA dehydrogenase precursor	382					carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity				0		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		TGTACACAGTCGTAAGCTACA	0.373													8	23					0.00307968	0.0078289	1	0	A	211057583	A	A	211057583	3	1	163	1	0	0	0	0	1	0	0	0	112	884	31	3	156	3	ACADL	2	211057583	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	512086	211057583	32141790	74	29579											
FN1	2335	broad.mit.edu	37	chr2	216248799	216248799	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggggctgtctccacggccaGtgacagcatacacagtgatg	9	7	13	12	2	1	2	0	2	1	0	2	2	1	2	2	3	2	2	2	3	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:216248799G>T	uc002vfa.2	-	30	5104	c.4838C>A	c.(4837-4839)ACT>AAT	p.T1613N	FN1_uc002vfb.2_Missense_Mutation_p.T1522N|FN1_uc002vfc.2_Missense_Mutation_p.T1522N|FN1_uc002vfd.2_Missense_Mutation_p.T1613N|FN1_uc002vfe.2_Missense_Mutation_p.T1522N|FN1_uc002vff.2_Missense_Mutation_p.T1522N|FN1_uc002vfg.2_Missense_Mutation_p.T1522N|FN1_uc002vfh.2_Missense_Mutation_p.T1522N|FN1_uc002vfi.2_Missense_Mutation_p.T1613N|FN1_uc002vfj.2_Missense_Mutation_p.T1613N|FN1_uc002vez.2_Translation_Start_Site|FN1_uc010zjp.1_Missense_Mutation_p.T240N|FN1_uc010fvc.1_5'Flank|FN1_uc010fvd.1_5'Flank	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCCACGGCCAGTGACAGCATA	0.498													37	57					4.46736e-08	1.28246e-07	1	0	T	216248799	T	T	216248799	3	4	163	1	0	0	0	0	1	0	0	0	5994	1029	36	4	2663	4	FN1	2	216248799	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	5191216	216248799	26950574	75	29580											
FN1	2335	broad.mit.edu	37	chr2	216271041	216271041	+	Frame_Shift_Del	DEL	G	-	-																															tgaagtaataggtgaccccaGgggacagcccggtgacttct																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:216271041delG	uc002vfa.2	-	19	3172	c.2906delC	c.(2905-2907)CCTfs	p.P969fs	FN1_uc002vfb.2_Frame_Shift_Del_p.P969fs|FN1_uc002vfc.2_Frame_Shift_Del_p.P969fs|FN1_uc002vfd.2_Frame_Shift_Del_p.P969fs|FN1_uc002vfe.2_Frame_Shift_Del_p.P969fs|FN1_uc002vff.2_Frame_Shift_Del_p.P969fs|FN1_uc002vfg.2_Frame_Shift_Del_p.P969fs|FN1_uc002vfh.2_Frame_Shift_Del_p.P969fs|FN1_uc002vfi.2_Frame_Shift_Del_p.P969fs|FN1_uc002vfj.2_Frame_Shift_Del_p.P969fs	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	969	|Fibronectin type-III 4.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGACCCCAGGGGACAGCCC	0.567													---	---	---								-	216271041	-	-	216271041	7	5	163	1	0	1	0	1	0	0	0	0	5994	1000	35	0	4639	0	FN1	2	216271041	Frame_Shift_Del	DEL	G	TCGA-CR-7398-01A-11D-2012-08	22242	216271041	26928332	76	29581											
CYP27A1	1593	broad.mit.edu	37	chr2	219677281	219677281	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtgcactactcagctatttGctacatcctgttcgagaaac	10	13	7	11	1	1	1	1	0	0	1	3	2	2	1	1	0	6	4	1	0	4	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:219677281G>T	uc002viz.3	+	4	1087	c.653G>T	c.(652-654)TGC>TTC	p.C218F		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	218					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	TCAGCTATTTGCTACATCCTG	0.547													118	155					7.7863e-71	3.04468e-70	1	0	T	219677281	T	T	219677281	3	4	163	1	0	0	0	0	1	0	0	0	4175	1319	46	4	667	4	CYP27A1	2	219677281	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	3406240	219677281	23522092	77	29582											
SPHKAP	80309	broad.mit.edu	37	chr2	228884716	228884716	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttgttaggttttctggagatCgttctgttttaatcaatggt	7	20	10	4	1	3	1	1	0	2	1	4	2	3	1	0	3	0	4	0	3	3	7	rs145402025		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:228884716C>G	uc002vpq.2	-	7	901	c.854G>C	c.(853-855)CGA>CCA	p.R285P	SPHKAP_uc002vpp.2_Missense_Mutation_p.R285P|SPHKAP_uc010zlx.1_Missense_Mutation_p.R285P	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	285						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCTGGAGATCGTTCTGTTTT	0.443													73	137					0	0	0	0	G	228884716	G	G	228884716	3	3	163	1	0	0	0	0	1	0	0	0	15114	884	31	3	4272	3	SPHKAP	2	228884716	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	9207435	228884716	14314657	78	29583											
CXCR7	57007	broad.mit.edu	37	chr2	237489774	237489774	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgttgtcttgggctttgcCgttcccttctccattatcgc	2	17	8	14	3	2	0	0	0	2	0	6	0	4	0	4	1	1	3	4	1	1	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:237489774C>T	uc010fyq.2	+	3	896	c.666C>T	c.(664-666)GCC>GCT	p.A222A	CXCR7_uc002vwd.2_Silent_p.A222A	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	222	Helical; Name=5; (Potential).				interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)		TGGGCTTTGCCGTTCCCTTCT	0.567													52	53					0	0	0	0	T	237489774	T	T	237489774	2	4	163	1	0	0	0	0	0	0	0	1	4113	639	23	1		1	CXCR7	2	237489774	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	8605058	237489774	5709599	79	29584											
MLPH	79083	broad.mit.edu	37	chr2	238449173	238449173	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctctcccccaggcggacccGgaggtaagactatcccccag	8	5	10	18	2	1	1	0	0	1	1	3	3	2	3	6	4	0	1	6	4	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:238449173G>T	uc002vwt.2	+	10	1514	c.1287G>T	c.(1285-1287)CCG>CCT	p.P429P	MLPH_uc002vws.2_Silent_p.P286P|MLPH_uc010fyt.1_Silent_p.P401P|MLPH_uc002vwu.2_Silent_p.P401P|MLPH_uc002vwv.2_Silent_p.P361P|MLPH_uc002vww.2_Silent_p.P377P|MLPH_uc002vwx.2_Silent_p.P285P|MLPH_uc010fyu.2_Silent_p.P181P	NM_024101	NP_077006	Q9BV36	MELPH_HUMAN	melanophilin isoform 1	429	Potential.						metal ion binding			ovary(1)	1		Breast(86;0.000381)|Renal(207;0.000966)|Ovarian(221;0.0695)|all_hematologic(139;0.095)|all_lung(227;0.17)|Melanoma(123;0.203)		Epithelial(121;1.17e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.02e-10)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.15e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000439)|Lung(119;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0316)		AGGCGGACCCGGAGGTAAGAC	0.637													13	9					5.50884e-06	1.49399e-05	1	0	T	238449173	T	T	238449173	2	4	163	1	0	0	0	0	0	0	0	1	9686	1103	39	3		3	MLPH	2	238449173	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	959399	238449173	4750200	80	29585											
ASB1	51665	broad.mit.edu	37	chr2	239344391	239344391	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtctggtgctgtggctggctCccctgcacaccgttgcgaat	4	11	13	13	2	1	0	0	0	1	0	2	1	2	0	3	3	3	5	3	3	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:239344391C>T	uc002vyg.2	+	3	317	c.231C>T	c.(229-231)CTC>CTT	p.L77L		NM_001040445	NP_001035535	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box-containing protein	77	ANK 2.				intracellular signal transduction|negative regulation of cytokine biosynthetic process						0		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		GTGGCTGGCTCCCCTGCACAC	0.632													15	23					0	0	0	0	T	239344391	T	T	239344391	2	4	163	1	0	0	0	0	0	0	0	1	1015	842	30	2		2	ASB1	2	239344391	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	895218	239344391	3854982	81	29586											
HDAC4	9759	broad.mit.edu	37	chr2	240029767	240029767	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcatttgccccggaggccCgtctcctgcaggcgggacca	5	7	13	16	4	1	0	0	0	1	0	3	2	1	2	5	4	2	2	5	4	0	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:240029767C>T	uc002vyk.3	-	15	2868	c.2076G>A	c.(2074-2076)ACG>ACA	p.T692T	HDAC4_uc010fyz.1_Silent_p.T687T|HDAC4_uc010zoa.1_Silent_p.T692T|HDAC4_uc010fza.2_Silent_p.T697T|HDAC4_uc010fyy.2_Silent_p.T649T|HDAC4_uc010znz.1_Silent_p.T575T	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	692	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CCCGGAGGCCCGTCTCCTGCA	0.677													11	20					0	0	0	0	T	240029767	T	T	240029767	2	4	163	1	0	0	0	0	0	0	0	1	7048	639	23	1		1	HDAC4	2	240029767	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	685376	240029767	3169606	82	29587											
CAPN10	11132	broad.mit.edu	37	chr2	241534551	241534551	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaaccccaaattctggctgCgggtctcagaaccgagtgag	10	7	12	12	2	2	2	1	1	2	1	3	3	2	2	3	2	3	2	3	2	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:241534551C>A	uc002vzk.1	+	7	1292	c.1108C>A	c.(1108-1110)CGG>AGG	p.R370R	CAPN10_uc010zoh.1_Silent_p.R370R|CAPN10_uc002vzl.1_Silent_p.R370R|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Silent_p.R242R|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	370	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		ATTCTGGCTGCGGGTCTCAGA	0.672													40	48					4.01765e-15	1.32089e-14	1	0	A	241534551	A	A	241534551	2	1	163	1	0	0	0	0	0	0	0	1	2635	759	27	3		3	CAPN10	2	241534551	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1504784	241534551	1664822	83	29588											
KIF1A	547	broad.mit.edu	37	chr2	241702653	241702653	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acgctgggcgaaggcccagtCcacaggctcagctggcgtct	7	6	14	14	3	2	0	1	0	1	0	3	1	3	0	2	4	1	3	2	4	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr2:241702653C>A	uc002vzy.2	-	20	1998	c.1852G>T	c.(1852-1854)GAC>TAC	p.D618Y	KIF1A_uc010fzk.2_Missense_Mutation_p.D627Y|KIF1A_uc002vzz.1_Missense_Mutation_p.D627Y	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	618					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		AAGGCCCAGTCCACAGGCTCA	0.652													9	18					5.4927e-09	1.60819e-08	1	0	A	241702653	A	A	241702653	3	1	163	1	0	0	0	0	1	0	0	0	8322	855	30	2	3332	2	KIF1A	2	241702653	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	168102	241702653	1496720	84	29589											
SLC6A11	6538	broad.mit.edu	37	chr3	10858101	10858101	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaaggcggtccacgagcgcGgccactggaacaacaaggtg	12	3	14	12	4	0	0	0	0	0	0	1	2	1	1	2	5	3	0	2	5	4	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:10858101G>C	uc003bvz.2	+	1	185	c.151G>C	c.(151-153)GGC>CGC	p.G51R	SLC6A11_uc003bvy.1_Missense_Mutation_p.G51R	NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	51	Cytoplasmic (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CCACGAGCGCGGCCACTGGAA	0.562													3	4					0	0	0	0	C	10858101	C	C	10858101	3	2	163	1	0	0	0	0	1	0	0	0	14738	1116	39	3	153	3	SLC6A11	3	10858101	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08		10858101	187164329	85	29590											
XIRP1	165904	broad.mit.edu	37	chr3	39229740	39229740	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccactcgctgtaggtgaccCacttggaccttgtctctgaa	7	12	9	13	1	1	2	0	2	1	0	4	3	2	3	3	2	0	2	3	2	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:39229740C>A	uc003cjk.1	-	2	1418	c.1197G>T	c.(1195-1197)GTG>GTT	p.V399V	XIRP1_uc003cji.2_Silent_p.V399V|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	399							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GTAGGTGACCCACTTGGACCT	0.592													60	53					1.27862e-28	4.71766e-28	1	0	A	39229740	A	A	39229740	2	1	163	1	0	0	0	0	0	0	0	1	17497	581	21	4		4	XIRP1	3	39229740	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	28371639	39229740	158792690	86	29591											
ITIH3	3699	broad.mit.edu	37	chr3	52829637	52829637	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaaacggagcctcccggaaGgggtaagaactttcaccagg	13	5	13	10	2	1	2	1	0	0	2	2	4	2	4	3	5	3	1	3	5	4	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:52829637G>T	uc003dfv.2	+	2	148	c.112G>T	c.(112-114)GGG>TGG	p.G38W	ITIH3_uc011bek.1_Missense_Mutation_p.G38W	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	38	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CCTCCCGGAAGGGGTAAGAAC	0.567													5	10					0.000157383	0.000411645	1	0	T	52829637	T	T	52829637	3	4	163	1	0	0	0	0	1	0	0	0	7944	1000	35	4	118	4	ITIH3	3	52829637	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	13599897	52829637	145192793	87	29592											
C3orf67	200844	broad.mit.edu	37	chr3	58817503	58817503	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggaggcactcaggccaTgggaggtcccagcatcctcc	7	6	13	15	0	1	0	1	0	0	0	4	2	4	2	5	5	1	2	5	5	0	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:58817503T>C	uc003dkt.1	-	13	1740	c.1331A>G	c.(1330-1332)CAT>CGT	p.H444R	C3orf67_uc003dkr.1_RNA|C3orf67_uc003dks.1_Missense_Mutation_p.H385R|uc003dku.1_Intron	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		ACTCAGGCCATGGGAGGTCCC	0.542													27	13					0	0	0	0	C	58817503	C	C	58817503	3	2	163	1	0	0	0	0	1	0	0	0	2251	1464	51	5	376	5	C3orf67	3	58817503	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	5987866	58817503	139204927	88	29593											
IFT57	55081	broad.mit.edu	37	chr3	107938307	107938307	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattgttgcattagggtcatCatattcttgaggctgctcaa	9	16	9	7	0	4	1	3	1	1	0	4	1	4	1	0	2	2	4	0	2	4	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:107938307C>A	uc003dwx.3	-	2	573	c.325G>T	c.(325-327)GAT>TAT	p.D109Y		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	109					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			TTAGGGTCATCATATTCTTGA	0.408													19	11					6.94344e-10	2.1063e-09	1	0	A	107938307	A	A	107938307	3	1	163	1	0	0	0	0	1	0	0	0	7601	826	29	2	1004	2	IFT57	3	107938307	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	49120804	107938307	90084123	89	29594											
VEPH1	79674	broad.mit.edu	37	chr3	157146252	157146252	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcttttcatacacagcaggTaacactctcaacaacatggt	13	11	6	11	0	2	0	2	0	1	0	3	0	2	0	0	2	6	3	0	2	4	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:157146252T>C	uc003fbj.1	-	5	872	c.555A>G	c.(553-555)TTA>TTG	p.L185L	VEPH1_uc003fbk.1_Silent_p.L185L|VEPH1_uc010hvu.1_Silent_p.L185L	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	185						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			ACACAGCAGGTAACACTCTCA	0.428													40	11					0	0	0	0	C	157146252	C	C	157146252	2	2	163	1	0	0	0	0	0	0	0	1	17222	1635	57	5		5	VEPH1	3	157146252	Silent	SNP	T	TCGA-CR-7398-01A-11D-2012-08	49207945	157146252	40876178	90	29595											
SI	6476	broad.mit.edu	37	chr3	164704993	164704993	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttatcatctgcagcaacaatGagcttcatgtgtttttgtcg	9	16	8	8	1	3	1	2	1	1	0	4	1	3	1	0	0	4	4	0	0	3	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:164704993G>A	uc003fei.2	-	45	5192	c.5130C>T	c.(5128-5130)CTC>CTT	p.L1710L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1710	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CAGCAACAATGAGCTTCATGT	0.348										HNSCC(35;0.089)			51	16					0	0	0	0	A	164704993	A	A	164704993	2	1	163	1	0	0	0	0	0	0	0	1	14362	1277	45	2		2	SI	3	164704993	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	7558741	164704993	33317437	91	29596											
SI	6476	broad.mit.edu	37	chr3	164741485	164741485	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctgttatacccatggatGaatagcgagctgagttgact	11	11	11	8	1	0	3	0	3	0	0	0	5	0	4	1	1	4	4	1	1	4	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:164741485G>T	uc003fei.2	-	26	3034	c.2972C>A	c.(2971-2973)TCA>TAA	p.S991*		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	991	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACCCATGGATGAATAGCGAGC	0.413										HNSCC(35;0.089)			17	26					3.45872e-05	9.2102e-05	1	0	T	164741485	T	T	164741485	4	4	163	1	0	0	0	0	0	1	0	0	14362	1294	45	2	2603	2	SI	3	164741485	Nonsense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	36492	164741485	33280945	92	29597											
SI	6476	broad.mit.edu	37	chr3	164766984	164766984	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtttaccccagttctgcAcagcatccatgcaaattgtt	10	13	6	12	0	1	0	0	0	1	0	2	0	2	0	3	0	4	6	3	0	2	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:164766984A>G	uc003fei.2	-	15	1708	c.1646T>C	c.(1645-1647)GTG>GCG	p.V549A		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	549	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CCAGTTCTGCACAGCATCCAT	0.338										HNSCC(35;0.089)			14	27					0	0	0	0	G	164766984	G	G	164766984	3	3	163	1	0	0	0	0	1	0	0	0	14362	159	6	5	3973	5	SI	3	164766984	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	25499	164766984	33255446	93	29598											
TRA2B	6434	broad.mit.edu	37	chr3	185636179	185636179	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtatgatcgagatctggaaCgtgatctgtatcctccacga	11	11	10	9	3	2	3	0	2	2	1	5	6	4	4	2	1	1	2	2	1	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:185636179C>A	uc003fpv.2	-	8	1106	c.830G>T	c.(829-831)CGT>CTT	p.R277L	TRA2B_uc003fpt.2_RNA|TRA2B_uc003fpu.2_RNA|TRA2B_uc010hym.2_Missense_Mutation_p.R177L|TRA2B_uc003fpw.2_Missense_Mutation_p.R257L	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	277	Arg/Ser-rich (RS2 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2						AGATCTGGAACGTGATCTGTA	0.368													21	50					1.96292e-10	6.01656e-10	1	0	A	185636179	A	A	185636179	3	1	163	1	0	0	0	0	1	0	0	0	16501	536	19	3	44	3	TRA2B	3	185636179	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	20869195	185636179	12386251	94	29599											
KNG1	3827	broad.mit.edu	37	chr3	186450367	186450367	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccaccaacagcccagagctGgaggagacactgactcacac	13	3	9	16	0	1	3	1	1	0	2	1	5	1	4	3	2	3	1	3	2	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:186450367G>T	uc011bsa.1	+	7	1046	c.834G>T	c.(832-834)CTG>CTT	p.L278L	KNG1_uc003fqr.2_Silent_p.L278L	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	278	Cystatin 3.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GCCCAGAGCTGGAGGAGACAC	0.443													10	110					4.68919e-08	1.34287e-07	1	0	T	186450367	T	T	186450367	2	4	163	1	0	0	0	0	0	0	0	1	8466	1335	47	4		4	KNG1	3	186450367	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	814188	186450367	11572063	95	29600											
OSTN	344901	broad.mit.edu	37	chr3	190936696	190936696	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaggagtttctctggttttgGgtctccccttgacagactct	6	15	10	10	0	3	2	0	1	3	1	5	3	3	3	2	3	0	2	2	3	1	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr3:190936696G>A	uc011bsn.1	+	2	263	c.263G>A	c.(262-264)GGG>GAG	p.G88E		NM_198184	NP_937827	P61366	OSTN_HUMAN	osteocrin precursor	88					cell differentiation|multicellular organismal development|ossification		hormone activity			pancreas(1)|skin(1)	2	all_cancers(143;6.79e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000254)		TCTGGTTTTGGGTCTCCCCTT	0.398													23	26					0	0	0	0	A	190936696	A	A	190936696	3	1	163	1	0	0	0	0	1	0	0	0	11353	1232	43	4	269	4	OSTN	3	190936696	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	4486329	190936696	7085734	96	29601											
STK32B	55351	broad.mit.edu	37	chr4	5458560	5458560	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacgaaatccactcggtcacGcccatcgatgaaatcctcaa	13	8	6	14	4	2	1	2	1	0	0	6	3	4	1	3	1	1	0	3	1	4	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:5458560G>A	uc003gih.1	+	8	757	c.693G>A	c.(691-693)ACG>ACA	p.T231T	STK32B_uc010ida.1_Silent_p.T184T	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	231	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						ACTCGGTCACGCCCATCGATG	0.532													10	6					0	0	0	0	A	5458560	A	A	5458560	2	1	163	1	0	0	0	0	0	0	0	1	15364	1074	38	1		1	STK32B	4	5458560	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08		5458560	185695716	97	29602											
GABRA2	2555	broad.mit.edu	37	chr4	46252554	46252554	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggatcttttgaaagattcGgggcataattggcaacagcc	11	11	11	8	1	1	2	0	1	1	1	2	3	1	3	1	4	2	2	1	4	3	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:46252554G>C	uc003gxc.3	-	9	1800	c.1127C>G	c.(1126-1128)CCG>CGG	p.P376R	GABRA2_uc010igc.2_Missense_Mutation_p.P376R|GABRA2_uc011bzc.1_Missense_Mutation_p.P381R	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	376	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGAAAGATTCGGGGCATAATT	0.418													60	35					0	0	0	0	C	46252554	C	C	46252554	3	2	163	1	0	0	0	0	1	0	0	0	6195	1116	39	3	232	3	GABRA2	4	46252554	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	40793994	46252554	144901722	98	29603											
UGT2A1	10941	broad.mit.edu	37	chr4	70513215	70513215	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggcaactaggacagtcaCattatgctcctttttaatga	13	12	8	8	0	1	2	1	1	0	1	2	3	2	3	1	2	2	2	1	2	4	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:70513215C>T	uc003hem.3	-	1	211	c.148G>A	c.(148-150)GTG>ATG	p.V50M	UGT2A1_uc011caq.1_Missense_Mutation_p.V50M|UGT2A1_uc010ihu.2_Missense_Mutation_p.V50M|UGT2A1_uc010iht.2_Missense_Mutation_p.V50M	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	50	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						AGGACAGTCACATTATGCTCC	0.393													17	24					0	0	0	0	T	70513215	T	T	70513215	3	4	163	1	0	0	0	0	1	0	0	0	17021	478	17	4	1459	4	UGT2A1	4	70513215	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	24260661	70513215	120641061	99	29604											
ODAM	54959	broad.mit.edu	37	chr4	71068636	71068636	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagctcccagaagagaaggTagagtcatgaaaacttcact	16	7	10	8	0	2	5	2	1	0	4	3	6	3	5	1	1	2	2	1	1	5	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:71068636T>C	uc003hfc.2	+	9	827	c.810_splice	c.e9+2	p.K270_splice		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein						biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						GAAGAGAAGGTAGAGTCATGA	0.353													13	11					0	0	0	0	C	71068636	C	C	71068636	5	2	163	1	0	0	0	0	0	0	1	0	10878	1652	57	5	846	5	ODAM	4	71068636	Splice_Site	SNP	T	TCGA-CR-7398-01A-11D-2012-08	555421	71068636	120085640	100	29605											
SMR3A	26952	broad.mit.edu	37	chr4	71232484	71232484	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccatcctccaccctatggtCcagggagatttccaccaccc	8	8	6	19	0	0	1	0	0	0	1	4	2	4	1	8	2	0	0	8	2	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:71232484C>A	uc003hfg.1	+	3	259	c.178C>A	c.(178-180)CCA>ACA	p.P60T	SMR3B_uc011cas.1_Intron	NM_012390	NP_036522	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3	60	Pro-rich.					extracellular region					0		all_hematologic(202;0.196)				ACCCTATGGTCCAGGGAGATT	0.557													17	90					2.35188e-11	7.32319e-11	1	0	A	71232484	A	A	71232484	3	1	163	1	0	0	0	0	1	0	0	0	14875	855	30	2	184	2	SMR3A	4	71232484	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	163848	71232484	119921792	101	29606											
SHROOM3	57619	broad.mit.edu	37	chr4	77660612	77660612	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaagtctccattcatagAggagcagctgcatactgtgc	10	10	10	11	0	2	2	1	1	1	1	3	3	2	3	2	1	5	3	2	1	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:77660612A>G	uc011cbx.1	+	5	2239	c.1286A>G	c.(1285-1287)GAG>GGG	p.E429G	SHROOM3_uc011cbz.1_Missense_Mutation_p.E253G|SHROOM3_uc003hkf.1_Missense_Mutation_p.E304G|SHROOM3_uc003hkg.2_Missense_Mutation_p.E207G	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	429					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CCATTCATAGAGGAGCAGCTG	0.577													21	47					0	0	0	0	G	77660612	G	G	77660612	3	3	163	1	0	0	0	0	1	0	0	0	14360	304	11	5	1304	5	SHROOM3	4	77660612	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	6428128	77660612	113493664	102	29607											
PDHA2	5161	broad.mit.edu	37	chr4	96762121	96762121	+	Frame_Shift_Del	DEL	G	-	-																															cagctaactactgtagatctGgaaaggggcccatactgatg																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:96762121delG	uc003htr.3	+	1	883	c.820delG	c.(820-822)GGAfs	p.G274fs		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	274					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CTGTAGATCTGGAAAGGGGCC	0.458													---	---	---								-	96762121	-	-	96762121	7	5	163	1	0	1	0	1	0	0	0	0	11719	1349	47	0	822	0	PDHA2	4	96762121	Frame_Shift_Del	DEL	G	TCGA-CR-7398-01A-11D-2012-08	19101509	96762121	94392155	103	29608											
RAP1GDS1	5910	broad.mit.edu	37	chr4	99337959	99337959	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctactagagattgttcagcAaaaagtggatagtgacaaag	16	10	10	5	0	2	2	1	1	1	1	2	4	2	3	0	1	2	2	0	1	6	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:99337959A>T	uc003htx.3	+	8	1017	c.827A>T	c.(826-828)CAA>CTA	p.Q276L	RAP1GDS1_uc003htw.3_Missense_Mutation_p.Q277L|RAP1GDS1_uc003htv.3_Missense_Mutation_p.Q277L|RAP1GDS1_uc003htz.3_Missense_Mutation_p.Q227L|RAP1GDS1_uc003hty.3_Missense_Mutation_p.Q228L|RAP1GDS1_uc003hua.3_Missense_Mutation_p.Q185L	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	276							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		ATTGTTCAGCAAAAAGTGGAT	0.363			T	NUP98	T-ALL								22	11					0	0	0	0	T	99337959	T	T	99337959	3	4	163	1	0	0	0	0	1	0	0	0	13104	130	5	5	860	5	RAP1GDS1	4	99337959	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	2575838	99337959	91816317	104	29609											
FBXW7	55294	broad.mit.edu	37	chr4	153247288	153247288	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccatcatattgaacacagCggactgctgcaacatgaccc	12	8	8	13	1	1	2	1	2	0	0	1	3	1	3	2	1	6	2	2	1	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:153247288C>A	uc003ims.2	-	10	1663	c.1514G>T	c.(1513-1515)CGC>CTC	p.R505L	FBXW7_uc011cii.1_Missense_Mutation_p.R505L|FBXW7_uc003imt.2_Missense_Mutation_p.R505L|FBXW7_uc011cih.1_Missense_Mutation_p.R329L|FBXW7_uc003imq.2_Missense_Mutation_p.R425L|FBXW7_uc003imr.2_Missense_Mutation_p.R387L	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(35)|p.R505L(7)|p.R505G(2)|p.R505H(2)|p.R266L(1)|p.R505S(1)|p.R505P(1)|p.R425L(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TTGAACACAGCGGACTGCTGC	0.468			Mis|N|D|F		colorectal|endometrial|T-ALL								37	26					4.11147e-13	1.315e-12	1	0	A	153247288	A	A	153247288	3	1	163	1	0	0	0	0	1	0	0	0	5801	768	27	3	621	3	FBXW7	4	153247288	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	53909329	153247288	37906988	105	29610											
DCHS2	54798	broad.mit.edu	37	chr4	155161859	155161859	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccaccactccagtgttctGatcaatagcaaacttggttc	11	11	6	13	0	2	1	1	1	1	0	4	1	3	1	3	1	2	3	3	1	3	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:155161859G>T	uc003inw.2	-	23	5824	c.5824C>A	c.(5824-5826)CAG>AAG	p.Q1942K		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1942	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCAGTGTTCTGATCAATAGCA	0.383													26	24					7.4402e-23	2.62189e-22	1	0	T	155161859	T	T	155161859	3	4	163	1	0	0	0	0	1	0	0	0	4305	1299	45	2	2938	2	DCHS2	4	155161859	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1914571	155161859	35992417	106	29611											
FSTL5	56884	broad.mit.edu	37	chr4	162841698	162841698	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgacgtttgcaaaggtccatAcaggcacattctgcttgccc	9	11	9	12	1	1	1	0	1	1	0	2	1	2	1	2	2	4	4	2	2	2	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:162841698A>T	uc003iqh.2	-	4	703	c.267T>A	c.(265-267)TGT>TGA	p.C89*	FSTL5_uc003iqi.2_Nonsense_Mutation_p.C88*|FSTL5_uc010iqv.2_Nonsense_Mutation_p.C88*	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	89	Kazal-like.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		AAAGGTCCATACAGGCACATT	0.458													13	5					0	0	0	0	T	162841698	T	T	162841698	4	4	163	1	0	0	0	0	0	1	0	0	6114	389	14	5	2328	5	FSTL5	4	162841698	Nonsense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	7679839	162841698	28312578	107	29612											
FAT1	2195	broad.mit.edu	37	chr4	187557372	187557372	+	Frame_Shift_Del	DEL	A	-	-																															gatgacttttgagggcgaccAttgtcaactgccttaatcta																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr4:187557372delA	uc003izf.2	-	6	4178	c.3990delT	c.(3988-3990)AATfs	p.N1330fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1330	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GAGGGCGACCATTGTCAACTG	0.428										HNSCC(5;0.00058)			---	---	---								-	187557372	-	-	187557372	7	5	163	1	0	1	0	1	0	0	0	0	5721	214	8	0	9864	0	FAT1	4	187557372	Frame_Shift_Del	DEL	A	TCGA-CR-7398-01A-11D-2012-08	24715674	187557372	3596904	108	29613											
CTNND2	1501	broad.mit.edu	37	chr5	11082811	11082811	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcagggagaacataccgaTgagctccttatttctgacgt	12	11	9	9	2	2	3	1	2	1	1	3	5	3	3	2	1	3	1	2	1	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:11082811T>C	uc003jfa.1	-	16	2930	c.2785A>G	c.(2785-2787)ATC>GTC	p.I929V	CTNND2_uc010itt.2_Missense_Mutation_p.I838V|CTNND2_uc011cmy.1_Missense_Mutation_p.I592V|CTNND2_uc011cmz.1_Missense_Mutation_p.I496V|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.I521V	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	929					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						AACATACCGATGAGCTCCTTA	0.507													137	104					0	0	0	0	C	11082811	C	C	11082811	3	2	163	1	0	0	0	0	1	0	0	0	4037	1464	51	5	920	5	CTNND2	5	11082811	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08		11082811	169832449	109	29614											
CDH9	1007	broad.mit.edu	37	chr5	26903843	26903843	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caatgctatactccatttctGcattttcccccacgtcaggg	8	13	6	14	1	2	0	1	0	1	0	4	0	4	0	3	1	3	2	3	1	3	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:26903843G>A	uc003jgs.1	-	6	1071	c.902C>T	c.(901-903)GCA>GTA	p.A301V	CDH9_uc010iug.2_Missense_Mutation_p.A301V	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	301	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CTCCATTTCTGCATTTTCCCC	0.413													84	176					0	0	0	0	A	26903843	A	A	26903843	3	1	163	1	0	0	0	0	1	0	0	0	3132	1319	46	4	1495	4	CDH9	5	26903843	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	15821032	26903843	154011417	110	29615											
RXFP3	51289	broad.mit.edu	37	chr5	33937868	33937868	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcctgtgttggctgccCaaccaggcgctcaccacctg	5	11	9	16	1	2	0	1	0	1	0	3	0	3	0	5	2	2	3	5	2	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:33937868C>A	uc003jic.1	+	1	1380	c.1023C>A	c.(1021-1023)CCC>CCA	p.P341P		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	341	Helical; Name=6; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GTTGGCTGCCCAACCAGGCGC	0.602													36	70					6.90743e-12	2.16801e-11	1	0	A	33937868	A	A	33937868	2	1	163	1	0	0	0	0	0	0	0	1	13826	581	21	4		4	RXFP3	5	33937868	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	7034025	33937868	146977392	111	29616											
SPEF2	79925	broad.mit.edu	37	chr5	35654677	35654677	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagatacagcaggccagaCaaccaccgatttgttaaata	15	10	7	9	1	0	2	0	0	0	2	0	3	0	2	3	1	3	2	3	1	6	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:35654677C>A	uc003jjo.2	+	7	938	c.827C>A	c.(826-828)ACA>AAA	p.T276K	SPEF2_uc003jjn.1_Missense_Mutation_p.T276K|SPEF2_uc003jjq.3_Missense_Mutation_p.T276K	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	276					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCAGGCCAGACAACCACCGAT	0.348													21	42					5.35356e-11	1.65384e-10	1	0	A	35654677	A	A	35654677	3	1	163	1	0	0	0	0	1	0	0	0	15101	478	17	4	853	4	SPEF2	5	35654677	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1716809	35654677	145260583	112	29617											
SPEF2	79925	broad.mit.edu	37	chr5	35727888	35727888	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagccacctaagccaggatCagaagaatgggtctatgtga	14	7	11	9	0	2	3	1	1	1	2	2	4	2	4	3	2	2	0	3	2	4	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:35727888C>A	uc003jjo.2	+	21	3137	c.3026C>A	c.(3025-3027)TCA>TAA	p.S1009*	SPEF2_uc003jjp.1_Nonsense_Mutation_p.S495*	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1009					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAGCCAGGATCAGAAGAATGG	0.428													93	62					3.37413e-40	1.30208e-39	1	0	A	35727888	A	A	35727888	4	1	163	1	0	0	0	0	0	1	0	0	15101	838	29	2	3129	2	SPEF2	5	35727888	Nonsense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	73211	35727888	145187372	113	29618											
FBXO4	26272	broad.mit.edu	37	chr5	41939628	41939628	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaagaccattgttggttttAtcttgtatttctcaagggga	9	16	11	5	0	2	1	1	0	2	1	3	3	2	3	1	4	0	3	1	4	4	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:41939628A>G	uc003jmq.2	+	6	1040	c.984A>G	c.(982-984)TTA>TTG	p.L328L	FBXO4_uc003jmr.2_Intron	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	328					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				TGTTGGTTTTATCTTGTATTT	0.393													57	145					0	0	0	0	G	41939628	G	G	41939628	2	3	163	1	0	0	0	0	0	0	0	1	5780	446	16	5		5	FBXO4	5	41939628	Silent	SNP	A	TCGA-CR-7398-01A-11D-2012-08	6211740	41939628	138975632	114	29619											
PDE4D	5144	broad.mit.edu	37	chr5	58287799	58287799	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttctccttttccttctgagTtggagaaggaatttccactt	7	18	7	9	0	2	2	0	1	2	1	5	4	4	3	3	2	0	1	3	2	2	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:58287799T>A	uc003jsa.2	-	8	1220	c.1048A>T	c.(1048-1050)ACT>TCT	p.T350S	PDE4D_uc003jrx.2_Missense_Mutation_p.T214S|PDE4D_uc003jry.2_Missense_Mutation_p.T48S|PDE4D_uc003jrz.2_Missense_Mutation_p.T286S|PDE4D_uc003jsb.2_Missense_Mutation_p.T289S|PDE4D_uc003jrt.2_Missense_Mutation_p.T48S|PDE4D_uc003jru.2_Missense_Mutation_p.T126S|PDE4D_uc003jrv.2_Missense_Mutation_p.T220S|PDE4D_uc003jrw.2_Missense_Mutation_p.T228S|PDE4D_uc003jrs.2_Missense_Mutation_p.T59S	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	350					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	TCCTTCTGAGTTGGAGAAGGA	0.318													7	1					0	0	0	0	A	58287799	A	A	58287799	3	1	163	1	0	0	0	0	1	0	0	0	11696	1725	60	5	1413	5	PDE4D	5	58287799	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	16348171	58287799	122627461	115	29620											
SERINC5	256987	broad.mit.edu	37	chr5	79498804	79498804	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tacatgaagcgggtgctgagGgactgccgaatcctggggca	9	7	16	9	2	0	2	0	2	0	0	1	4	1	3	2	4	4	2	2	4	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:79498804G>C	uc003kgj.2	-	2	225	c.96C>G	c.(94-96)TCC>TCG	p.S32S	SERINC5_uc003kgk.2_Silent_p.S32S|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Silent_p.S32S|SERINC5_uc011ctj.1_Silent_p.S32S	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	32	Extracellular (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GGGTGCTGAGGGACTGCCGAA	0.552													7	5					0	0	0	0	C	79498804	C	C	79498804	2	2	163	1	0	0	0	0	0	0	0	1	14148	1219	43	4		4	SERINC5	5	79498804	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	21211005	79498804	101416456	116	29621											
GPR98	84059	broad.mit.edu	37	chr5	89933676	89933676	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatggctctgttttgtttttAtctgggcaaagtgacacaac	10	15	9	7	0	2	1	0	1	2	0	2	1	2	1	0	2	1	4	0	2	4	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:89933676A>T	uc003kju.2	+	11	2247	c.2151A>T	c.(2149-2151)TTA>TTT	p.L717F	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	717	Calx-beta 5.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTTGTTTTTATCTGGGCAAA	0.418													23	14					0	0	0	0	T	89933676	T	T	89933676	3	4	163	1	0	0	0	0	1	0	0	0	6760	446	16	5	2193	5	GPR98	5	89933676	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	10434872	89933676	90981584	117	29622											
APC	324	broad.mit.edu	37	chr5	112175215	112175215	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgcaaatagcagaaataaaAgaaaagattggaactaggtc	20	7	9	5	0	0	3	0	0	0	3	1	4	0	4	0	2	3	2	0	2	9	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:112175215A>G	uc010jby.2	+	16	4304	c.3924A>G	c.(3922-3924)AAA>AAG	p.K1308K	APC_uc011cvt.1_Silent_p.K1290K|APC_uc003kpz.3_Silent_p.K1308K|APC_uc003kpy.3_Silent_p.K1308K|APC_uc010jbz.2_Silent_p.K1025K|APC_uc010jca.2_Silent_p.K608K	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1308	Ser-rich.|Responsible for down-regulation through a process mediated by direct ubiquitination.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E1309fs*6(50)|p.E1309fs*4(32)|p.I1307fs*6(12)|p.K1308*(6)|p.?(1)|p.E1309fs*5(1)|p.K1192fs*3(1)|p.K1308E(1)|p.K1308fs*4(1)|p.K1308fs*6(1)|p.I1307fs*13(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CAGAAATAAAAGAAAAGATTG	0.428		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			30	6					0	0	0	0	G	112175215	G	G	112175215	2	3	163	1	0	0	0	0	0	0	0	1	763	69	3	5		5	APC	5	112175215	Silent	SNP	A	TCGA-CR-7398-01A-11D-2012-08	22241539	112175215	68740045	118	29623											
ADAMTS19	171019	broad.mit.edu	37	chr5	129037215	129037215	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagggactgcattgggcccaAgcccgcctctgcccagcgct	6	6	13	16	2	1	0	0	0	1	0	1	2	1	1	4	2	4	2	4	2	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:129037215A>T	uc003kvb.1	+	20	3071	c.3071A>T	c.(3070-3072)AAG>ATG	p.K1024M	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1024	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ATTGGGCCCAAGCCCGCCTCT	0.577													18	17					0	0	0	0	T	129037215	T	T	129037215	3	4	163	1	0	0	0	0	1	0	0	0	264	72	3	5	3149	5	ADAMTS19	5	129037215	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	16862000	129037215	51878045	119	29624											
PCDHA2	56146	broad.mit.edu	37	chr5	140176493	140176493	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcccctcgacaccgcctactCgtgctggtgaaggaccacgg	7	7	11	16	4	0	1	0	1	0	0	3	3	1	2	5	3	2	1	5	3	2	1	rs140366950		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:140176493C>T	uc003lhd.2	+	1	2050	c.1944C>T	c.(1942-1944)CTC>CTT	p.L648L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.L648L|PCDHA2_uc011czy.1_Silent_p.L648L	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	648	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGCCTACTCGTGCTGGTGA	0.652													48	16					0	0	0	0	T	140176493	T	T	140176493	2	4	163	1	0	0	0	0	0	0	0	1	11578	871	31	1		1	PCDHA2	5	140176493	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	11139278	140176493	40738767	120	29625											
PCDHGB6	56100	broad.mit.edu	37	chr5	140788253	140788253	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accctgccacggatcctgatAtaaacataaactcaattaaa	17	9	4	11	1	1	1	1	1	0	0	2	2	2	2	3	1	3	0	3	1	8	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:140788253A>T	uc003lkj.1	+	1	484	c.484A>T	c.(484-486)ATA>TTA	p.I162L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.I162L	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	162	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATCCTGATATAAACATAAA	0.363													12	5					0	0	0	0	T	140788253	T	T	140788253	3	4	163	1	0	0	0	0	1	0	0	0	11621	449	16	5	486	5	PCDHGB6	5	140788253	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	611760	140788253	40127007	121	29626											
DOCK2	1794	broad.mit.edu	37	chr5	169461490	169461490	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaggcctcctggagaagctGctggattaccggggtgtgat	9	9	15	8	1	0	2	0	1	0	1	1	4	1	3	3	5	3	2	3	5	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:169461490G>A	uc003maf.2	+	35	3635	c.3555G>A	c.(3553-3555)CTG>CTA	p.L1185L	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.L677L	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1185	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGAGAAGCTGCTGGATTACC	0.587													23	13					0	0	0	0	A	169461490	A	A	169461490	2	1	163	1	0	0	0	0	0	0	0	1	4709	1306	46	4		4	DOCK2	5	169461490	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	28673237	169461490	11453770	122	29627											
NSD1	64324	broad.mit.edu	37	chr5	176675268	176675269	+	Frame_Shift_Ins	INS	-	A	A																															atcccgggatgcctgcctctINSaaaaaaatgcagggtgaacg																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr5:176675268_176675269insA	uc003mfr.3	+	11	4722_4723	c.4584_4585insA	c.(4582-4587)TCTAAAfs	p.S1528fs	NSD1_uc003mft.3_Frame_Shift_Ins_p.S1259fs|NSD1_uc003mfs.1_Frame_Shift_Ins_p.S1425fs|NSD1_uc011dfx.1_Frame_Shift_Ins_p.S1176fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1528_1529					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TGCCTGCCTCTAAAAAAATGCA	0.495			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---								A	176675269	A	A	176675268	7	5	163	1	0	1	1	0	0	0	0	0	10723	1509	53	0	4622	0	NSD1	5	176675268	Frame_Shift_Ins	INS	-	TCGA-CR-7398-01A-11D-2012-08	7213778	176675268	4239992	123	29628											
DSP	1832	broad.mit.edu	37	chr6	7568065	7568066	+	Frame_Shift_Ins	INS	-	C	C																															cctgaaggggctccaggactINSccatcaggaagaagtacccc																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:7568065_7568066insC	uc003mxp.1	+	10	1471_1472	c.1192_1193insC	c.(1192-1194)TCCfs	p.S398fs	DSP_uc003mxq.1_Frame_Shift_Ins_p.S398fs	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	398	Globular 1.|Spectrin 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCTCCAGGACTCCATCAGGAAG	0.515													---	---	---								C	7568066	C	C	7568065	7	5	163	1	0	1	1	0	0	0	0	0	4803	1551	54	0	1230	0	DSP	6	7568065	Frame_Shift_Ins	INS	-	TCGA-CR-7398-01A-11D-2012-08		7568065	163547002	124	29629											
TXNDC5	81567	broad.mit.edu	37	chr6	7884653	7884653	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcggcgatcttgacccccGccagaccagggaattccttt	7	10	9	15	3	1	2	0	1	1	1	3	4	2	3	5	2	0	0	5	2	1	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:7884653G>A	uc003mxv.2	-	9	1147	c.1115C>T	c.(1114-1116)GCG>GTG	p.A372V	TXNDC5_uc003mxw.2_Missense_Mutation_p.A329V|TXNDC5_uc010jnz.2_Missense_Mutation_p.A264V	NM_030810	NP_110437	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 1	372	Thioredoxin 3.				anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)					CTTGACCCCCGCCAGACCAGG	0.488													41	104					0	0	0	0	A	7884653	A	A	7884653	3	1	163	1	0	0	0	0	1	0	0	0	16867	1087	38	1	191	1	TXNDC5	6	7884653	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	316588	7884653	163230414	125	29630											
OR14J1	442191	broad.mit.edu	37	chr6	29274874	29274874	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tatgagactattatggatccCcgtgcctgtaggcatgcagt	9	12	11	9	1	0	1	0	1	0	1	1	3	1	2	3	2	2	3	3	2	4	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:29274874C>G	uc011dln.1	+	1	408	c.408C>G	c.(406-408)CCC>CCG	p.P136P		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTATGGATCCCCGTGCCTGTA	0.502													58	136					0	0	0	0	G	29274874	G	G	29274874	2	3	163	1	0	0	0	0	0	0	0	1	11002	610	22	4		4	OR14J1	6	29274874	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	21390221	29274874	141840193	126	29631											
OR10C1	442194	broad.mit.edu	37	chr6	29408338	29408338	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttctgtgagatccagccTgtcctgcagctggtatgtgg	5	14	12	10	0	2	1	0	1	2	1	4	2	4	1	3	2	3	3	3	2	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:29408338T>A	uc011dlp.1	+	1	546	c.546T>A	c.(544-546)CCT>CCA	p.P182P	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGATCCAGCCTGTCCTGCAGC	0.582													62	168					0	0	0	0	A	29408338	A	A	29408338	2	1	163	1	0	0	0	0	0	0	0	1	10952	1567	55	5		5	OR10C1	6	29408338	Silent	SNP	T	TCGA-CR-7398-01A-11D-2012-08	133464	29408338	141706729	127	29632											
TRIM39	56658	broad.mit.edu	37	chr6	30297214	30297214	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtatctgaaggaacctgtCatcattgagtgtgggcacaa	12	10	12	7	0	3	2	2	2	1	0	3	4	3	3	1	2	1	2	1	2	4	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:30297214C>T	uc010jrz.2	+	3	432	c.120C>T	c.(118-120)GTC>GTT	p.V40V	HCG18_uc003npx.2_5'Flank|HCG18_uc003npy.2_5'Flank|TRIM39_uc003npz.2_Silent_p.V40V|TRIM39_uc003nqb.2_Silent_p.V40V|TRIM39_uc003nqc.2_Silent_p.V40V|TRIM39_uc010jsa.1_Silent_p.V40V	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	40	RING-type.				apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						AGGAACCTGTCATCATTGAGT	0.562													141	114					0	0	0	0	T	30297214	T	T	30297214	2	4	163	1	0	0	0	0	0	0	0	1	16580	813	29	2		2	TRIM39	6	30297214	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	888876	30297214	140817853	128	29633											
DHX16	8449	broad.mit.edu	37	chr6	30627269	30627269	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcgtgccccaggtggtgTgggctggaagatacgggcct	5	10	16	10	2	0	1	0	0	0	1	1	2	0	2	3	5	2	1	3	5	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:30627269T>A	uc003nqz.2	-	12	2199	c.1987A>T	c.(1987-1989)ACA>TCA	p.T663S	DHX16_uc003nqy.2_Missense_Mutation_p.T182S|DHX16_uc011dmo.1_Missense_Mutation_p.T603S	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	663	Helicase C-terminal.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						CCAGGTGGTGTGGGCTGGAAG	0.582													9	7					0	0	0	0	A	30627269	A	A	30627269	3	1	163	1	0	0	0	0	1	0	0	0	4524	1696	59	5	1174	5	DHX16	6	30627269	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	330055	30627269	140487798	129	29634											
MICB	4277	broad.mit.edu	37	chr6	31477636	31477636	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcagcacagctgggatttCagcctctgatgtcagctact	9	11	10	11	0	3	1	2	1	1	0	3	2	3	2	1	1	6	4	1	1	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:31477636C>G	uc003ntn.3	+	6	1218	c.1102C>G	c.(1102-1104)CAG>GAG	p.Q368E	MICB_uc011dnm.1_Missense_Mutation_p.Q336E|MICB_uc003nto.3_Missense_Mutation_p.Q325E	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	368	Cytoplasmic (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						GCTGGGATTTCAGCCTCTGAT	0.577													68	55					0	0	0	0	G	31477636	G	G	31477636	3	3	163	1	0	0	0	0	1	0	0	0	9628	827	29	2	1124	2	MICB	6	31477636	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	850367	31477636	139637431	130	29635											
C6orf27	80737	broad.mit.edu	37	chr6	31743183	31743183	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctgctcgcccagctccacCcagttgctatgactgtagaa	8	10	9	14	1	0	2	0	1	0	1	2	2	1	2	3	0	4	6	3	0	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:31743183C>T	uc011dog.1	-	4	775	c.537G>A	c.(535-537)TGG>TGA	p.W179*	C6orf27_uc003nxd.2_5'UTR|C6orf27_uc011doh.1_RNA	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	179						extracellular region				ovary(3)	3						CCAGCTCCACCCAGTTGCTAT	0.587													35	20					0	0	0	0	T	31743183	T	T	31743183	4	4	163	1	0	0	0	0	0	1	0	0	2372	624	22	4	2193	4	C6orf27	6	31743183	Nonsense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	265547	31743183	139371884	131	29636											
DNAH8	1769	broad.mit.edu	37	chr6	38851748	38851748	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttattgatgatattaatatgCctgtgattaatgagtgggga	12	16	11	2	0	0	4	0	4	0	0	0	5	0	5	1	2	1	0	1	2	5	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:38851748C>A	uc003ooe.1	+	54	8182	c.7582C>A	c.(7582-7584)CCT>ACT	p.P2528T		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TATTAATATGCCTGTGATTAA	0.328													12	20					0.00010058	0.000264838	1	0	A	38851748	A	A	38851748	3	1	163	1	0	0	0	0	1	0	0	0	4629	739	26	4	7788	4	DNAH8	6	38851748	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	7108565	38851748	132263319	132	29637											
DNAH8	1769	broad.mit.edu	37	chr6	38919096	38919096	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttgtattcatttttaggtCttggtgcccagaccgtactg	7	16	9	9	1	2	1	1	0	1	1	2	1	2	1	2	2	2	2	2	2	3	8			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:38919096C>A	uc003ooe.1	+	80	12200	c.11600C>A	c.(11599-11601)TCT>TAT	p.S3867Y	DNAH8_uc003oog.1_Missense_Mutation_p.S316Y|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATTTTTAGGTCTTGGTGCCCA	0.338													39	61					9.62906e-15	3.13077e-14	1	0	A	38919096	A	A	38919096	3	1	163	1	0	0	0	0	1	0	0	0	4629	913	32	2	11910	2	DNAH8	6	38919096	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	67348	38919096	132195971	133	29638											
HSP90AB1	3326	broad.mit.edu	37	chr6	44219990	44219990	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatgaaagaaatcttagatAagaaggttgagaaggtaagc	18	9	11	3	0	2	5	1	2	1	4	2	6	2	5	0	2	1	2	0	2	7	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:44219990A>T	uc003oxa.1	+	10	1801	c.1717A>T	c.(1717-1719)AAG>TAG	p.K573*	HSP90AB1_uc011dvr.1_Nonsense_Mutation_p.K563*|HSP90AB1_uc003oxb.1_Nonsense_Mutation_p.K573*|HSP90AB1_uc011dvs.1_Nonsense_Mutation_p.K393*|HSP90AB1_uc003oxc.1_Nonsense_Mutation_p.K211*	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	573					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AATCTTAGATAAGAAGGTTGA	0.443													19	31					0	0	0	0	T	44219990	T	T	44219990	4	4	163	1	0	0	0	0	0	1	0	0	7441	363	13	5	1751	5	HSP90AB1	6	44219990	Nonsense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	5300894	44219990	126895077	134	29639											
ENPP4	22875	broad.mit.edu	37	chr6	46108938	46108938	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgaaggctggacaattgtgCtaaatgaatcatcacaaaaa	18	9	8	6	0	2	2	2	2	0	0	2	3	2	3	0	2	1	2	0	2	7	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:46108938C>T	uc003oxy.2	+	3	1235	c.976C>T	c.(976-978)CTA>TTA	p.L326L		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	326	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						GACAATTGTGCTAAATGAATC	0.338													19	19					0	0	0	0	T	46108938	T	T	46108938	2	4	163	1	0	0	0	0	0	0	0	1	5156	796	28	4		4	ENPP4	6	46108938	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1888948	46108938	125006129	135	29640											
PKHD1	5314	broad.mit.edu	37	chr6	51484071	51484071	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagctgattttggcctgcCagctggtatctgagcaactg	8	11	12	10	0	1	2	0	2	1	0	1	2	1	2	2	2	6	5	2	2	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:51484071C>T	uc003pah.1	-	67	12309	c.12033G>A	c.(12031-12033)CTG>CTA	p.L4011L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	4011	Cytoplasmic (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TTTGGCCTGCCAGCTGGTATC	0.567													30	43					0	0	0	0	T	51484071	T	T	51484071	2	4	163	1	0	0	0	0	0	0	0	1	12026	581	21	4		4	PKHD1	6	51484071	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	5375133	51484071	119630996	136	29641											
HCRTR2	3062	broad.mit.edu	37	chr6	55120039	55120039	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagcacagcaaagcgggccCgtaacagcattgtcatcatc	13	6	10	12	2	2	1	2	0	0	1	3	1	2	1	1	1	5	4	1	1	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:55120039C>T	uc003pcl.2	+	3	823	c.508C>T	c.(508-510)CGT>TGT	p.R170C	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.R105C	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	170	Cytoplasmic (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAAGCGGGCCCGTAACAGCAT	0.502													32	48					0	0	0	0	T	55120039	T	T	55120039	3	4	163	1	0	0	0	0	1	0	0	0	7041	652	23	1	518	1	HCRTR2	6	55120039	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	3635968	55120039	115995028	137	29642											
EYS	346007	broad.mit.edu	37	chr6	66204788	66204788	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcagagattcctggcagaaCtgctgtttcactgtcacatt	9	13	8	11	0	3	2	3	0	0	2	4	3	4	2	1	1	2	3	1	1	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:66204788C>A	uc011dxu.1	-	4	1054	c.516G>T	c.(514-516)CAG>CAT	p.Q172H	EYS_uc003peq.2_Missense_Mutation_p.Q172H|EYS_uc003per.1_Missense_Mutation_p.Q172H|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	172	EGF-like 1.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CCTGGCAGAACTGCTGTTTCA	0.453													13	30					2.68362e-12	8.49092e-12	1	0	A	66204788	A	A	66204788	3	1	163	1	0	0	0	0	1	0	0	0	5357	564	20	4	9040	4	EYS	6	66204788	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	11084749	66204788	104910279	138	29643											
BAI3	577	broad.mit.edu	37	chr6	70092801	70092802	+	Frame_Shift_Ins	INS	-	G	G																															tcaaactttggacagatttcINSgggatataccaaatacaagc																								rs148278852		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:70092801_70092802insG	uc003pev.3	+	31	4802_4803	c.4354_4355insG	c.(4354-4356)CGGfs	p.R1452fs	BAI3_uc010kak.2_Frame_Shift_Ins_p.R1452fs|BAI3_uc011dxx.1_Frame_Shift_Ins_p.R658fs	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1452	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GGACAGATTTCGGGATATACCA	0.386													---	---	---								G	70092802	G	G	70092801	7	5	163	1	0	1	1	0	0	0	0	0	1302	875	31	0	4468	0	BAI3	6	70092801	Frame_Shift_Ins	INS	-	TCGA-CR-7398-01A-11D-2012-08	3888013	70092801	101022266	139	29644											
C6orf165	154313	broad.mit.edu	37	chr6	88127994	88127994	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attaccagcttgagactgccCggagccaggtataccgctac	10	8	10	13	2	0	1	0	1	0	1	0	3	0	2	4	2	6	3	4	2	4	5	rs140079201		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:88127994C>A	uc003plv.2	+	7	792	c.700C>A	c.(700-702)CGG>AGG	p.R234R	C6orf165_uc003plw.2_Silent_p.R46R|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Silent_p.R234R	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	234										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TGAGACTGCCCGGAGCCAGGT	0.488													22	37					7.45023e-12	2.33216e-11	1	0	A	88127994	A	A	88127994	2	1	163	1	0	0	0	0	0	0	0	1	2351	643	23	3		3	C6orf165	6	88127994	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	18035193	88127994	82987073	140	29645											
FUT9	10690	broad.mit.edu	37	chr6	96651430	96651430	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cccttccagaaatggatttgGatgaatttggaatcaccaac	13	11	8	9	0	1	2	1	1	0	1	2	5	2	5	3	3	1	0	3	3	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:96651430G>C	uc003pop.3	+	3	740	c.399G>C	c.(397-399)TGG>TGC	p.W133C		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	133	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		AATGGATTTGGATGAATTTGG	0.458													15	25					0	0	0	0	C	96651430	C	C	96651430	3	2	163	1	0	0	0	0	1	0	0	0	6145	1183	41	2	401	2	FUT9	6	96651430	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	8523436	96651430	74463637	141	29646											
FUT9	10690	broad.mit.edu	37	chr6	96651555	96651555	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcttcttgacggtaagcaCaaatcccttcgtgtttgaag	9	13	10	9	2	1	2	0	2	1	0	3	2	2	2	1	2	1	4	1	2	3	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:96651555C>G	uc003pop.3	+	3	865	c.524C>G	c.(523-525)ACA>AGA	p.T175R		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	175	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		ACGGTAAGCACAAATCCCTTC	0.463													18	38					0	0	0	0	G	96651555	G	G	96651555	3	3	163	1	0	0	0	0	1	0	0	0	6145	478	17	4	526	4	FUT9	6	96651555	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	125	96651555	74463512	142	29647											
C6orf204	387119	broad.mit.edu	37	chr6	118802981	118802981	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actccttttctttctttttcTggcatattaactgtgtctct	5	22	4	10	0	4	0	0	0	4	0	6	0	5	0	1	1	1	1	1	1	2	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:118802981T>A	uc003pxz.1	-	8	2294	c.1706A>T	c.(1705-1707)CAG>CTG	p.Q569L	C6orf204_uc003pya.1_Missense_Mutation_p.Q572L	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	569	Potential.					centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		TTTCTTTTTCTGGCATATTAA	0.269													6	15					0	0	0	0	A	118802981	A	A	118802981	3	1	163	1	0	0	0	0	1	0	0	0	2363	1580	55	5	735	5	C6orf204	6	118802981	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	22151426	118802981	52312086	143	29648											
PTPRK	5796	broad.mit.edu	37	chr6	128385930	128385930	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcaatgcgtacgcactgggTtttagtttcctgatagagta	10	13	11	7	2	0	2	0	1	0	1	1	2	1	2	1	1	3	6	1	1	5	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:128385930T>A	uc003qbk.2	-	13	2534	c.2167A>T	c.(2167-2169)ACC>TCC	p.T723S	PTPRK_uc003qbj.2_Missense_Mutation_p.T723S|PTPRK_uc010kfc.2_Missense_Mutation_p.T723S|PTPRK_uc011ebu.1_Missense_Mutation_p.T723S|PTPRK_uc003qbl.1_Missense_Mutation_p.T593S|PTPRK_uc011ebv.1_Missense_Mutation_p.T723S	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	723	Extracellular (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ACGCACTGGGTTTTAGTTTCC	0.343													17	37					0	0	0	0	A	128385930	A	A	128385930	3	1	163	1	0	0	0	0	1	0	0	0	12870	1725	60	5	2249	5	PTPRK	6	128385930	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	9582949	128385930	42729137	144	29649											
LAMA2	3908	broad.mit.edu	37	chr6	129419489	129419489	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccccgcactgggccaccgTcatatgccaaagatgatgag	11	7	10	13	2	1	3	1	2	0	1	2	3	2	3	5	1	1	1	5	1	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:129419489T>C	uc003qbn.2	+	4	673	c.568T>C	c.(568-570)TCA>CCA	p.S190P	LAMA2_uc003qbo.2_Missense_Mutation_p.S190P	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	190	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGGGCCACCGTCATATGCCAA	0.443													31	40					0	0	0	0	C	129419489	C	C	129419489	3	2	163	1	0	0	0	0	1	0	0	0	8646	1667	58	5	582	5	LAMA2	6	129419489	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	1033559	129419489	41695578	145	29650											
ENPP1	5167	broad.mit.edu	37	chr6	132203596	132203596	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataacaccaaagtgagttacGggttcctctccccaccacgt	11	9	7	14	2	1	1	0	1	1	0	3	1	2	1	5	1	2	2	5	1	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:132203596G>C	uc011ecf.1	+	21	2232	c.2212G>C	c.(2212-2214)GGG>CGG	p.G738R		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	738	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	AGTGAGTTACGGGTTCCTCTC	0.383													35	56					0	0	0	0	C	132203596	C	C	132203596	3	2	163	1	0	0	0	0	1	0	0	0	5153	1116	39	3	2294	3	ENPP1	6	132203596	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2784107	132203596	38911471	146	29651											
BCLAF1	9774	broad.mit.edu	37	chr6	136597402	136597402	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agatgcagtagcaaaactttTaccctgatctgcgaggactg	12	10	10	9	1	1	2	0	1	1	1	1	4	1	3	1	1	5	3	1	1	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:136597402T>A	uc003qgx.1	-	5	1514	c.1261A>T	c.(1261-1263)AAA>TAA	p.K421*	BCLAF1_uc003qgw.1_Intron|BCLAF1_uc003qgy.1_Nonsense_Mutation_p.K419*|BCLAF1_uc011edc.1_Intron|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Nonsense_Mutation_p.K419*	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	421					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GCAAAACTTTTACCCTGATCT	0.423													97	225					0	0	0	0	A	136597402	A	A	136597402	4	1	163	1	0	0	0	0	0	1	0	0	1385	1763	61	5	1537	5	BCLAF1	6	136597402	Nonsense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	4393806	136597402	34517665	147	29652											
VTA1	51534	broad.mit.edu	37	chr6	142487415	142487415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatcgatagtaaaactcctGaatgtcgcaaatttttatca	15	13	6	7	2	1	2	1	1	0	1	4	3	2	2	1	0	1	2	1	0	6	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:142487415G>A	uc003qiw.2	+	2	178	c.163G>A	c.(163-165)GAA>AAA	p.E55K	VTA1_uc011edt.1_RNA|VTA1_uc011edu.1_Intron	NM_016485	NP_057569	Q9NP79	VTA1_HUMAN	Vps20-associated 1 homolog	55	Interaction with CHMP5.|Interaction with IST1.				cellular membrane organization|endosome transport|protein transport	cytosol|endosome membrane	protein binding				0	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;1.34e-05)|GBM - Glioblastoma multiforme(68;0.00182)		TAAAACTCCTGAATGTCGCAA	0.299													21	32					0	0	0	0	A	142487415	A	A	142487415	3	1	163	1	0	0	0	0	1	0	0	0	17301	1291	45	2	169	2	VTA1	6	142487415	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	5890013	142487415	28627652	148	29653											
STX11	8676	broad.mit.edu	37	chr6	144507960	144507960	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggccgacgtgaagcggctgGgaaagcagaacgcccgcttc	9	5	15	12	5	0	2	0	1	0	1	1	4	0	3	2	3	3	3	2	3	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:144507960G>T	uc003qks.3	+	2	388	c.196G>T	c.(196-198)GGA>TGA	p.G66*		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	66	Potential.				cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		GAAGCGGCTGGGAAAGCAGAA	0.622									Familial_Hemophagocytic_Lymphohistiocytosis				12	18					4.84862e-15	1.58964e-14	1	0	T	144507960	T	T	144507960	4	4	163	1	0	0	0	0	0	1	0	0	15403	1233	43	4	198	4	STX11	6	144507960	Nonsense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2020545	144507960	26607107	149	29654											
GRM1	2911	broad.mit.edu	37	chr6	146720539	146720539	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacgaggccaaatatatcgcGttcaccatgtacaccacctg	13	8	7	13	3	1	0	1	0	0	0	2	1	1	0	4	1	2	2	4	1	5	4	rs114187147	byFrequency	TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:146720539G>C	uc010khw.1	+	8	2834	c.2364G>C	c.(2362-2364)GCG>GCC	p.A788A	GRM1_uc010khv.1_Silent_p.A788A|GRM1_uc003qll.2_Silent_p.A788A|GRM1_uc011edz.1_Silent_p.A788A|GRM1_uc011eea.1_Silent_p.A788A	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	788	Helical; Name=6; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AATATATCGCGTTCACCATGT	0.488													48	73					0	0	0	0	C	146720539	C	C	146720539	2	2	163	1	0	0	0	0	0	0	0	1	6835	1132	40	3		3	GRM1	6	146720539	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2212579	146720539	24394528	150	29655											
GRM1	2911	broad.mit.edu	37	chr6	146755774	146755774	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aactgaccccggatgattcgCctgcgctgacgcctccgtcg	6	8	11	16	6	0	3	0	3	0	0	3	4	1	4	5	1	2	1	5	1	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:146755774C>T	uc010khw.1	+	9	3897	c.3427C>T	c.(3427-3429)CCT>TCT	p.P1143S	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1143	Ser-rich.|Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGATGATTCGCCTGCGCTGAC	0.662													41	45					0	0	0	0	T	146755774	T	T	146755774	3	4	163	1	0	0	0	0	1	0	0	0	6835	739	26	4	3522	4	GRM1	6	146755774	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	35235	146755774	24359293	151	29656											
FNDC1	84624	broad.mit.edu	37	chr6	159677661	159677661	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaacctaaagcccaacacGaggtacgatgtgtcagtcat	14	7	10	10	2	2	1	2	0	0	1	2	4	2	1	2	1	4	1	2	1	5	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:159677661G>T	uc010kjv.2	+	18	5372	c.5172G>T	c.(5170-5172)ACG>ACT	p.T1724T		NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1724	Fibronectin type-III 5.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGCCCAACACGAGGTACGATG	0.423													53	72					1.38658e-30	5.19745e-30	1	0	T	159677661	T	T	159677661	2	4	163	1	0	0	0	0	0	0	0	1	6000	1045	37	3		3	FNDC1	6	159677661	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	12921887	159677661	11437406	152	29657											
MAS1	4142	broad.mit.edu	37	chr6	160328115	160328115	+	Frame_Shift_Del	DEL	C	-	-																															ctgggtcattatgagcatctCcccagtggggtttgttgaga																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr6:160328115delC	uc003qsz.2	+	1	142	c.128delC	c.(127-129)TCCfs	p.S43fs		NM_002377	NP_002368	P04201	MAS_HUMAN	MAS1 oncogene	43	Helical; Name=1; (Potential).				anatomical structure morphogenesis|cell proliferation|protein kinase C signaling cascade	integral to plasma membrane	angiotensin type II receptor activity			ovary(2)|lung(2)	4		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.6e-06)		ATGAGCATCTCCCCAGTGGGG	0.522													---	---	---								-	160328115	-	-	160328115	7	5	163	1	0	1	0	1	0	0	0	0	9373	855	30	0	130	0	MAS1	6	160328115	Frame_Shift_Del	DEL	C	TCGA-CR-7398-01A-11D-2012-08	650454	160328115	10786952	153	29658											
CRHR2	1395	broad.mit.edu	37	chr7	30701809	30701809	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcttgccgatggcccaggCgacgatgatggggaagggga	9	5	19	8	3	0	1	0	1	0	0	0	7	0	3	2	6	2	1	2	6	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr7:30701809C>A	uc003tbn.2	-	7	965	c.721G>T	c.(721-723)GCC>TCC	p.A241S	CRHR2_uc010kvw.1_Missense_Mutation_p.A241S|CRHR2_uc010kvx.1_Missense_Mutation_p.A240S|CRHR2_uc010kvy.1_Missense_Mutation_p.A77S|CRHR2_uc003tbo.2_Missense_Mutation_p.A227S|CRHR2_uc003tbp.2_Missense_Mutation_p.A268S	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	241	Helical; Name=4; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						ATGGCCCAGGCGACGATGATG	0.562													35	52					5.71845e-15	1.86962e-14	1	0	A	30701809	A	A	30701809	3	1	163	1	0	0	0	0	1	0	0	0	3887	768	27	3	538	3	CRHR2	7	30701809	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08		30701809	128436854	154	29659											
POM121L12	285877	broad.mit.edu	37	chr7	53103797	53103797	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcgggatcgcgccccctGagcgtcaggagagcccctgg	6	5	14	16	4	1	2	1	1	0	1	3	4	1	3	5	3	2	0	5	3	0	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr7:53103797G>T	uc003tpz.2	+	1	449	c.433G>T	c.(433-435)GAG>TAG	p.E145*		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	145											0						CGCGCCCCCTGAGCGTCAGGA	0.577													11	24					1.5842e-08	4.60396e-08	1	0	T	53103797	T	T	53103797	4	4	163	1	0	0	0	0	0	1	0	0	12296	1291	45	2	435	2	POM121L12	7	53103797	Nonsense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	22401988	53103797	106034866	155	29660											
ZNF107	51427	broad.mit.edu	37	chr7	64168848	64168848	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagagaaaccctacaaatgTgaagaatgtggcaaatcctt	16	9	8	8	0	1	3	1	1	0	2	2	4	2	3	2	1	2	1	2	1	6	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr7:64168848T>G	uc003ttd.2	+	7	2952	c.2166T>G	c.(2164-2166)TGT>TGG	p.C722W	ZNF107_uc003tte.2_Missense_Mutation_p.C722W	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	722	C2H2-type 24.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CCTACAAATGTGAAGAATGTG	0.348													10	11					0	0	0	0	G	64168848	G	G	64168848	3	3	163	1	0	0	0	0	1	0	0	0	17782	1702	59	5	2172	5	ZNF107	7	64168848	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	11065051	64168848	94969815	156	29661											
ZNF273	10793	broad.mit.edu	37	chr7	64388382	64388382	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaactaactcagcataagAaaactgctactagagtgaat	18	8	6	9	0	1	3	1	1	0	2	1	3	1	3	0	0	6	2	0	0	8	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr7:64388382A>G	uc003tto.2	+	4	752	c.676A>G	c.(676-678)AAA>GAA	p.K226E	ZNF273_uc003ttl.2_Missense_Mutation_p.K161E|ZNF273_uc003ttn.2_Missense_Mutation_p.K161E	NM_021148	NP_066971	Q14593	ZN273_HUMAN	zinc finger protein 273	226	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(55;0.0295)|all_lung(88;0.0691)				TCAGCATAAGAAAACTGCTAC	0.313													36	32					0	0	0	0	G	64388382	G	G	64388382	3	3	163	1	0	0	0	0	1	0	0	0	17875	247	9	5	690	5	ZNF273	7	64388382	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	219534	64388382	94750281	157	29662											
ZSCAN21	7589	broad.mit.edu	37	chr7	99654694	99654694	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcctccacaggagcaggtggGgcctctgatggtaaaagtcg	9	7	15	10	1	1	1	0	1	1	0	3	2	2	2	3	5	1	2	3	5	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr7:99654694G>A	uc003uso.2	+	2	209	c.65G>A	c.(64-66)GGG>GAG	p.G22E	ZSCAN21_uc011kje.1_Missense_Mutation_p.G21E|ZSCAN21_uc003usn.1_Missense_Mutation_p.G21E	NM_145914	NP_666019	Q9Y5A6	ZSC21_HUMAN	zinc finger protein 38	22					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GAGCAGGTGGGGCCTCTGATG	0.537													79	44					0	0	0	0	A	99654694	A	A	99654694	3	1	163	1	0	0	0	0	1	0	0	0	18300	1232	43	4	67	4	ZSCAN21	7	99654694	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	35266312	99654694	59483969	158	29663											
IQUB	154865	broad.mit.edu	37	chr7	123092911	123092911	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgaagccagcactggaacCtgagaaaaatagttcttagc	16	8	9	8	0	1	2	0	2	1	1	1	4	1	3	2	1	4	2	2	1	7	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr7:123092911C>A	uc003vkn.2	-	13	2839	c.2262G>T	c.(2260-2262)CAG>CAT	p.Q754H	IQUB_uc011kny.1_Missense_Mutation_p.Q87H|IQUB_uc003vko.2_Missense_Mutation_p.Q754H|IQUB_uc010lkt.2_RNA	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	754										ovary(3)|large_intestine(1)	4						GCACTGGAACCTGAGAAAAAT	0.348													12	5					1.49906e-05	4.03751e-05	1	0	A	123092911	A	A	123092911	3	1	163	1	0	0	0	0	1	0	0	0	7859	680	24	4	117	4	IQUB	7	123092911	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	23438217	123092911	36045752	159	29664											
PLXNA4	91584	broad.mit.edu	37	chr7	131831391	131831391	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcttgactccactctccaGgtcaggagtgatcataggtg	9	11	10	11	0	4	2	2	2	2	0	6	3	5	3	2	3	0	0	2	3	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr7:131831391G>C	uc003vra.3	-	28	5162	c.4933C>G	c.(4933-4935)CTG>GTG	p.L1645V	PLXNA4_uc003vqz.3_5'Flank	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1645	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CCACTCTCCAGGTCAGGAGTG	0.577													85	50					0	0	0	0	C	131831391	C	C	131831391	3	2	163	1	0	0	0	0	1	0	0	0	12177	991	35	4	771	4	PLXNA4	7	131831391	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	8738480	131831391	27307272	160	29665											
LRGUK	136332	broad.mit.edu	37	chr7	133884049	133884049	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgaacaaggaaaaatatgaGggatatttgcggagaaaagg	19	7	13	2	1	0	3	0	2	0	1	0	6	0	5	0	4	2	0	0	4	8	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr7:133884049G>C	uc003vrm.1	+	14	1639	c.1623G>C	c.(1621-1623)GAG>GAC	p.E541D		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	541	Guanylate kinase-like.						ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						AAAAATATGAGGGATATTTGC	0.363													39	25					0	0	0	0	C	133884049	C	C	133884049	3	2	163	1	0	0	0	0	1	0	0	0	8993	991	35	4	1677	4	LRGUK	7	133884049	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2052658	133884049	25254614	161	29666											
LONRF1	91694	broad.mit.edu	37	chr8	12586411	12586411	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagcacattttaaaataccTtaacatcttccagatattca	17	13	2	9	0	2	1	1	0	1	1	3	1	3	1	2	0	3	1	2	0	6	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:12586411T>G	uc003wwd.1	-	10	2072	c.2009A>C	c.(2008-2010)AAG>ACG	p.K670T	LONRF1_uc011kxv.1_Missense_Mutation_p.K259T|LONRF1_uc010lsp.1_Missense_Mutation_p.K270T	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	670	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		TTAAAATACCTTAACATCTTC	0.403													28	47					0	0	0	0	G	12586411	G	G	12586411	3	3	163	1	0	0	0	0	1	0	0	0	8944	1623	56	5	324	5	LONRF1	8	12586411	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08		12586411	133777611	162	29667											
UNC5D	137970	broad.mit.edu	37	chr8	35542267	35542267	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgcacttctctttgtcctGgtgagatatatgcagattcc	7	15	8	11	0	1	2	0	1	1	2	4	3	3	2	3	1	2	2	3	1	2	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:35542267G>T	uc003xjr.1	+	6	1247	c.919G>T	c.(919-921)GTG>TTG	p.V307L	UNC5D_uc003xjs.1_Missense_Mutation_p.V302L|UNC5D_uc003xjt.1_Missense_Mutation_p.V76L	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	307	Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TCTTTGTCCTGGTGAGATATA	0.463													24	44					6.36457e-07	1.76677e-06	1	0	T	35542267	T	T	35542267	3	4	163	1	0	0	0	0	1	0	0	0	17063	1362	47	4	941	4	UNC5D	8	35542267	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	22955856	35542267	110821755	163	29668											
PROSC	11212	broad.mit.edu	37	chr8	37623867	37623867	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaacaaaatgtcaacaaaTtgatgggtaagataaaatta	22	9	7	3	0	1	3	1	1	0	2	1	3	1	3	0	1	2	1	0	1	9	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:37623867T>C	uc003xkh.2	+	4	390	c.313T>C	c.(313-315)TTG>CTG	p.L105L		NM_007198	NP_009129	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog	105							pyridoxal phosphate binding			central_nervous_system(1)	1		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	TGTCAACAAATTGATGGGTAA	0.363													53	65					0	0	0	0	C	37623867	C	C	37623867	2	2	163	1	0	0	0	0	0	0	0	1	12621	1490	52	5		5	PROSC	8	37623867	Silent	SNP	T	TCGA-CR-7398-01A-11D-2012-08	2081600	37623867	108740155	164	29669											
PRKDC	5591	broad.mit.edu	37	chr8	48697683	48697683	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggttaactcaccgggaatctCcagctcatttctcaggaact	10	11	8	12	1	4	0	3	0	2	0	6	2	4	2	2	3	3	2	2	3	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:48697683C>A	uc003xqi.2	-	78	11155	c.11098G>T	c.(11098-11100)GAG>TAG	p.E3700*	PRKDC_uc003xqj.2_Nonsense_Mutation_p.E3700*|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3700					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CCGGGAATCTCCAGCTCATTT	0.453								NHEJ					23	32					3.01185e-09	9.02022e-09	1	0	A	48697683	A	A	48697683	4	1	163	1	0	0	0	0	0	1	0	0	12583	864	30	2	1328	2	PRKDC	8	48697683	Nonsense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	11073816	48697683	97666339	165	29670											
RP1	6101	broad.mit.edu	37	chr8	55538955	55538955	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatttttatgcaccgcaatCtcaagcagaagtggcatctg	12	11	9	9	1	2	2	1	0	2	2	3	2	2	2	1	1	2	4	1	1	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:55538955C>T	uc003xsd.1	+	4	2661	c.2513C>T	c.(2512-2514)TCT>TTT	p.S838F	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	838					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GCACCGCAATCTCAAGCAGAA	0.313													22	32					0	0	0	0	T	55538955	T	T	55538955	3	4	163	1	0	0	0	0	1	0	0	0	13597	913	32	2	2523	2	RP1	8	55538955	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	6841272	55538955	90825067	166	29671											
RP1	6101	broad.mit.edu	37	chr8	55542017	55542017	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaggagaagggtagtcatCagtcagaaagagtatgcaca	16	6	13	6	0	3	4	3	0	0	4	3	5	3	4	0	2	1	3	0	2	4	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:55542017C>G	uc003xsd.1	+	4	5723	c.5575C>G	c.(5575-5577)CAG>GAG	p.Q1859E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1859					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGGTAGTCATCAGTCAGAAAG	0.418													24	20					0	0	0	0	G	55542017	G	G	55542017	3	3	163	1	0	0	0	0	1	0	0	0	13597	827	29	2	5585	2	RP1	8	55542017	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	3062	55542017	90822005	167	29672											
DCAF4L2	138009	broad.mit.edu	37	chr8	88886016	88886016	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaggagggatcccagctatGaatctggacctttttcctct	9	12	10	10	0	2	2	0	1	2	1	4	5	4	5	3	3	1	1	3	3	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:88886016G>A	uc003ydz.2	-	1	281	c.184C>T	c.(184-186)CAT>TAT	p.H62Y		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	62										ovary(1)	1						TCCCAGCTATGAATCTGGACC	0.512													39	50					0	0	0	0	A	88886016	A	A	88886016	3	1	163	1	0	0	0	0	1	0	0	0	4289	1290	45	2	1007	2	DCAF4L2	8	88886016	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	33343999	88886016	57478006	168	29673											
RUNX1T1	862	broad.mit.edu	37	chr8	93003886	93003886	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccataggtctgtttctgtcCctgaggtccctgtggctggg	3	13	13	12	0	2	1	0	1	2	0	4	1	4	1	3	4	0	2	3	4	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:93003886C>T	uc003yfd.2	-	6	1056	c.972G>A	c.(970-972)AGG>AGA	p.R324R	RUNX1T1_uc003yfc.1_Silent_p.R297R|RUNX1T1_uc003yfe.1_Silent_p.R287R|RUNX1T1_uc010mao.2_Silent_p.R297R|RUNX1T1_uc011lgi.1_Silent_p.R335R|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Silent_p.R287R	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	324					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TGTTTCTGTCCCTGAGGTCCC	0.512													51	107					0	0	0	0	T	93003886	T	T	93003886	2	4	163	1	0	0	0	0	0	0	0	1	13812	622	22	4		4	RUNX1T1	8	93003886	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	4117870	93003886	53360136	169	29674											
UBR5	51366	broad.mit.edu	37	chr8	103297762	103297762	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgtaagtttactgcatcttgGtaagtcaatttcacagctgc	10	15	8	8	0	3	0	2	0	1	0	3	0	3	0	0	1	4	5	0	1	4	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:103297762G>C	uc003ykr.1	-	39	5496	c.5463C>G	c.(5461-5463)TAC>TAG	p.Y1821*	UBR5_uc003yks.1_Nonsense_Mutation_p.Y1821*	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1821					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTGCATCTTGGTAAGTCAATT	0.373													11	69					0	0	0	0	C	103297762	C	C	103297762	4	2	163	1	0	0	0	0	0	1	0	0	16973	1256	44	4	3020	4	UBR5	8	103297762	Nonsense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	10293876	103297762	43066260	170	29675											
PKHD1L1	93035	broad.mit.edu	37	chr8	110489571	110489571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tattctccaggattgctttcCtgtacatccgccatcaagaa	10	13	6	12	1	2	1	1	0	1	1	5	2	4	2	4	1	2	2	4	1	4	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:110489571C>T	uc003yne.2	+	53	9139	c.9035C>T	c.(9034-9036)CCT>CTT	p.P3012L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3012	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GATTGCTTTCCTGTACATCCG	0.408										HNSCC(38;0.096)			23	33					0	0	0	0	T	110489571	T	T	110489571	3	4	163	1	0	0	0	0	1	0	0	0	12027	681	24	4	9245	4	PKHD1L1	8	110489571	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	7191809	110489571	35874451	171	29676											
CSMD3	114788	broad.mit.edu	37	chr8	113259248	113259248	+	Splice_Site	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttcttatccataatacttaCgtatgcattcaggctgaatc	11	16	5	9	1	2	1	1	1	1	0	4	1	3	1	1	1	3	3	1	1	6	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:113259248C>A	uc003ynu.2	-	64	10381	c.10222_splice	c.e64+1	p.P3408_splice	CSMD3_uc003yns.2_Splice_Site_p.P2610_splice|CSMD3_uc003ynt.2_Splice_Site_p.P3368_splice|CSMD3_uc011lhx.1_Splice_Site_p.P3239_splice	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1							integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATAATACTTACGTATGCATTC	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	35					1.15088e-07	3.27194e-07	1	0	A	113259248	A	A	113259248	5	1	163	1	0	0	0	0	0	0	1	0	3963	550	19	3	932	3	CSMD3	8	113259248	Splice_Site	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2769677	113259248	33104774	172	29677											
NOV	4856	broad.mit.edu	37	chr8	120430512	120430512	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaagtggatctgtggcccAgatgaggaggattcactggg	11	8	16	6	0	2	2	1	1	1	1	2	6	2	5	1	5	0	0	1	5	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:120430512A>T	uc003yoq.2	+	3	746	c.525A>T	c.(523-525)CCA>CCT	p.P175P		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	175					regulation of cell growth		growth factor activity|insulin-like growth factor binding	p.P175A(1)		ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTGTGGCCCAGATGAGGAGG	0.502													50	78					0	0	0	0	T	120430512	T	T	120430512	2	4	163	1	0	0	0	0	0	0	0	1	10607	175	7	5		5	NOV	8	120430512	Silent	SNP	A	TCGA-CR-7398-01A-11D-2012-08	7171264	120430512	25933510	173	29678											
LYPD2	137797	broad.mit.edu	37	chr8	143832542	143832542	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcgatggtgacacagtcCgacactcctgtgggctccgg	6	8	15	12	3	0	1	0	1	0	0	3	3	3	1	3	4	0	1	3	4	0	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr8:143832542C>A	uc003ywz.2	-	2	188	c.105G>T	c.(103-105)TCG>TCT	p.S35S		NM_205545	NP_991108	Q6UXB3	LYPD2_HUMAN	LY6/PLAUR domain containing 2 precursor	35	UPAR/Ly6.					anchored to membrane|plasma membrane					0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGACACAGTCCGACACTCCTG	0.652													46	61					1.23713e-20	4.28265e-20	1	0	A	143832542	A	A	143832542	2	1	163	1	0	0	0	0	0	0	0	1	9161	639	23	3		3	LYPD2	8	143832542	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	23402030	143832542	2531480	174	29679											
PTPRD	5789	broad.mit.edu	37	chr9	8485777	8485777	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctaccttgatccacaggcaGtgtcctgaactggacactgg	9	9	10	13	0	0	2	0	2	0	0	2	3	2	3	4	3	2	1	4	3	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:8485777G>T	uc003zkk.2	-	27	3751	c.3040C>A	c.(3040-3042)CTG>ATG	p.L1014M	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.L1005M|PTPRD_uc003zkm.2_Missense_Mutation_p.L1001M|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1014	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCCACAGGCAGTGTCCTGAAC	0.448										TSP Lung(15;0.13)			13	13					2.68362e-12	8.49092e-12	1	0	T	8485777	T	T	8485777	3	4	163	1	0	0	0	0	1	0	0	0	12864	1020	36	4	2842	4	PTPRD	9	8485777	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08		8485777	132727654	175	29680											
IFNA6	3443	broad.mit.edu	37	chr9	21350709	21350709	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactcctcctggggaaatcTgaagtcatgtctgtccttca	10	12	8	11	0	4	1	2	1	2	0	7	2	7	2	3	2	1	0	3	2	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:21350709T>C	uc011lni.1	-	1	178	c.178A>G	c.(178-180)AGA>GGA	p.R60G		NM_021002	NP_066282	P05013	IFNA6_HUMAN	interferon, alpha 6 precursor	60					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TGGGGAAATCTGAAGTCATGT	0.522													64	30					0	0	0	0	C	21350709	C	C	21350709	3	2	163	1	0	0	0	0	1	0	0	0	7580	1588	55	5	393	5	IFNA6	9	21350709	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	12864932	21350709	119862722	176	29681											
FAM75A3	727830	broad.mit.edu	37	chr9	40702701	40702701	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actttggtcagctctccggtCcagaccccccaggtgaggtg	6	9	12	14	1	2	2	1	1	1	1	4	2	3	2	5	4	1	1	5	4	0	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:40702701C>A	uc010mmj.2	+	4	387	c.358C>A	c.(358-360)CCA>ACA	p.P120T		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	120	Pro-rich.					integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GCTCTCCGGTCCAGACCCCCC	0.627													22	108					1.04352e-10	3.20684e-10	1	0	A	40702701	A	A	40702701	3	1	163	1	0	0	0	0	1	0	0	0	5653	855	30	2	372	2	FAM75A3	9	40702701	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	19351992	40702701	100510730	177	29682											
TRPM6	140803	broad.mit.edu	37	chr9	77354822	77354822	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcctctcgggacaatacCtggatcattgccgctctccc	7	11	7	16	2	4	0	1	0	3	0	7	2	4	2	4	2	2	1	4	2	2	2	rs144713167		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:77354822C>A	uc004ajl.1	-	34	5542	c.5304G>T	c.(5302-5304)CAG>CAT	p.Q1768H	TRPM6_uc004ajk.1_Missense_Mutation_p.Q1763H|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.Q719H|TRPM6_uc010mpd.1_Missense_Mutation_p.Q601H|TRPM6_uc010mpe.1_Missense_Mutation_p.Q315H|TRPM6_uc004ajj.1_Missense_Mutation_p.Q724H	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1768	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GGGACAATACCTGGATCATTG	0.498													33	53					2.08457e-15	6.87265e-15	1	0	A	77354822	A	A	77354822	3	1	163	1	0	0	0	0	1	0	0	0	16657	680	24	4	788	4	TRPM6	9	77354822	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	36652121	77354822	63858609	178	29683											
RASEF	158158	broad.mit.edu	37	chr9	85627405	85627405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacatcttccttttgacttaCgcgttttgattgttcttcga	6	19	6	10	3	2	2	0	2	2	0	4	3	3	2	1	0	1	2	1	0	1	9			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:85627405C>T	uc004amo.1	-	5	1048	c.787G>A	c.(787-789)GTA>ATA	p.V263I		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	263	Potential.				protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						TTTTGACTTACGCGTTTTGAT	0.333													5	14					0	0	0	0	T	85627405	T	T	85627405	3	4	163	1	0	0	0	0	1	0	0	0	13133	536	19	1	1487	1	RASEF	9	85627405	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	8272583	85627405	55586026	179	29684											
C9orf102	375748	broad.mit.edu	37	chr9	98678717	98678717	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgcctaagaaggaagaccggGtaagaaccgcatttgtatat	14	9	11	7	2	0	3	0	0	0	3	0	4	0	4	3	2	2	3	3	2	7	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:98678717G>A	uc004avt.3	+	6	1579	c.1191_splice	c.e6+1	p.R397_splice	C9orf102_uc010mrx.1_Splice_Site|C9orf102_uc011lum.1_Splice_Site_p.R99_splice|C9orf102_uc010mry.1_Splice_Site_p.R99_splice|C9orf102_uc010mrz.2_Splice_Site_p.R208_splice	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein						DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				GGAAGACCGGGTAAGAACCGC	0.383													26	37					0	0	0	0	A	98678717	A	A	98678717	5	1	163	1	0	0	0	0	0	0	1	0	2457	1275	44	4	1214	4	C9orf102	9	98678717	Splice_Site	SNP	G	TCGA-CR-7398-01A-11D-2012-08	13051312	98678717	42534714	180	29685											
MUSK	4593	broad.mit.edu	37	chr9	113459720	113459720	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagcctcgggacagcatattCcaaagtggtgaagctggaag	12	7	13	9	1	0	1	0	1	0	0	2	3	1	3	2	3	3	2	2	3	4	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:113459720C>T	uc004bey.2	+	5	700	c.602C>T	c.(601-603)TCC>TTC	p.S201F	MUSK_uc004bex.2_Missense_Mutation_p.S201F	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	201	Ig-like 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						ACAGCATATTCCAAAGTGGTG	0.507													46	42					0	0	0	0	T	113459720	T	T	113459720	3	4	163	1	0	0	0	0	1	0	0	0	10042	855	30	2	620	2	MUSK	9	113459720	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	14781003	113459720	27753711	181	29686											
ZNF883	169834	broad.mit.edu	37	chr9	115760032	115760032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaatgaattccctgatgttCaattaggtgtgtgctgcggc	9	13	12	7	1	1	3	1	2	0	1	2	3	2	3	1	2	2	2	1	2	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:115760032C>T	uc011lwy.1	-	5	1747	c.508G>A	c.(508-510)GAA>AAA	p.E170K		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	170	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCCTGATGTTCAATTAGGTGT	0.403													29	45					0	0	0	0	T	115760032	T	T	115760032	3	4	163	1	0	0	0	0	1	0	0	0	18265	835	29	2	633	2	ZNF883	9	115760032	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2300312	115760032	25453399	182	29687											
ZNF618	114991	broad.mit.edu	37	chr9	116764924	116764924	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acaccgaagccacctcagggGagggagcctcccaaagcagt	12	3	12	14	1	1	0	1	0	0	0	2	3	2	2	5	3	3	1	5	3	2	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:116764924G>T	uc004bid.2	+	6	631	c.532G>T	c.(532-534)GAG>TAG	p.E178*	ZNF618_uc004bib.1_Nonsense_Mutation_p.E146*|ZNF618_uc004bic.2_Nonsense_Mutation_p.E146*|ZNF618_uc011lxi.1_Nonsense_Mutation_p.E146*|ZNF618_uc011lxj.1_Nonsense_Mutation_p.E146*	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACCTCAGGGGAGGGAGCCTC	0.612													27	81					0.000147802	0.00038831	1	0	T	116764924	T	T	116764924	4	4	163	1	0	0	0	0	0	1	0	0	18109	1175	41	2	454	2	ZNF618	9	116764924	Nonsense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1004892	116764924	24448507	183	29688											
COL27A1	85301	broad.mit.edu	37	chr9	117071686	117071686	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccaagcaggccgtacgcttCcgggcctggaatggacagat	9	6	14	12	3	0	1	0	0	0	1	1	3	1	3	4	4	2	3	4	4	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:117071686C>T	uc011lxl.1	+	60	5364	c.5364C>T	c.(5362-5364)TTC>TTT	p.F1788F	COL27A1_uc004bii.2_RNA|COL27A1_uc011lxn.1_Silent_p.F103F	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1788	Fibrillar collagen NC1.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CCGTACGCTTCCGGGCCTGGA	0.607													46	66					0	0	0	0	T	117071686	T	T	117071686	2	4	163	1	0	0	0	0	0	0	0	1	3700	854	30	2		2	COL27A1	9	117071686	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	306762	117071686	24141745	184	29689											
FBXW2	26190	broad.mit.edu	37	chr9	123550177	123550177	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagccttcaaataaaccttCttccagtgcaaagcgtcctg	12	11	6	12	1	2	0	1	0	1	0	4	0	4	0	4	0	4	1	4	0	5	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:123550177C>T	uc004bkl.1	-	3	521	c.360G>A	c.(358-360)AAG>AAA	p.K120K	FBXW2_uc011lyc.1_5'UTR|FBXW2_uc004bkn.2_Silent_p.K152K|FBXW2_uc004bkm.1_Silent_p.K120K|FBXW2_uc010mvj.1_Silent_p.K120K	NM_012164	NP_036296	Q9UKT8	FBXW2_HUMAN	F-box and WD repeat domain containing 2	120					proteolysis		protein binding|ubiquitin-protein ligase activity			urinary_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						AATAAACCTTCTTCCAGTGCA	0.443													45	55					0	0	0	0	T	123550177	T	T	123550177	2	4	163	1	0	0	0	0	0	0	0	1	5798	912	32	2		2	FBXW2	9	123550177	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	6478491	123550177	17663254	185	29690											
OR1Q1	158131	broad.mit.edu	37	chr9	125377755	125377755	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcggctcccacctcactGtggtggccatattctatggc	5	11	10	15	1	2	0	1	0	1	0	3	0	3	0	4	4	1	1	4	4	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:125377755G>A	uc011lyy.1	+	1	739	c.739G>A	c.(739-741)GTG>ATG	p.V247M		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCACCTCACTGTGGTGGCCAT	0.547													44	72					0	0	0	0	A	125377755	A	A	125377755	3	1	163	1	0	0	0	0	1	0	0	0	11025	1377	48	4	741	4	OR1Q1	9	125377755	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1827578	125377755	15835676	186	29691											
OR1B1	347169	broad.mit.edu	37	chr9	125391641	125391641	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagataatacatgggtgaGtgcagtctggagtcccagga	12	8	14	7	0	1	2	0	1	1	1	2	4	2	4	1	3	3	2	1	3	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:125391641G>A	uc011lyz.1	-	1	174	c.174C>T	c.(172-174)CAC>CAT	p.H58H		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	58	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACATGGGTGAGTGCAGTCTGG	0.522													20	37					0	0	0	0	A	125391641	A	A	125391641	2	1	163	1	0	0	0	0	0	0	0	1	11005	1020	36	4		4	OR1B1	9	125391641	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	13886	125391641	15821790	187	29692											
LCN1	3933	broad.mit.edu	37	chr9	138415086	138415086	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctgttttccaggataagtgGccggtgccaggaggtgaagg	8	10	16	7	1	1	1	0	1	1	0	2	3	2	3	3	6	1	1	3	6	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:138415086G>C	uc004cfz.1	+	3	288	c.230G>C	c.(229-231)GGC>GCC	p.G77A	LCN1_uc004cga.1_Missense_Mutation_p.G77A	NM_002297	NP_002288	P31025	LCN1_HUMAN	lipocalin 1 precursor	77					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		AGGATAAGTGGCCGGTGCCAG	0.637													11	33					0	0	0	0	C	138415086	C	C	138415086	3	2	163	1	0	0	0	0	1	0	0	0	8720	1203	42	4	240	4	LCN1	9	138415086	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	13023445	138415086	2798345	188	29693											
CACNA1B	774	broad.mit.edu	37	chr9	140901299	140901299	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagcaaaggcatgttctcGtccttttacttcattgtcct	7	16	7	11	1	3	0	2	0	1	0	6	0	5	0	2	1	2	3	2	1	2	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr9:140901299G>A	uc004cog.2	+	16	2200	c.2055G>A	c.(2053-2055)TCG>TCA	p.S685S	CACNA1B_uc011mfd.1_Silent_p.S216S	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	685	Helical; Name=S6 of repeat II; (Potential).|II.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GCATGTTCTCGTCCTTTTACT	0.552													6	17					0	0	0	0	A	140901299	A	A	140901299	2	1	163	1	0	0	0	0	0	0	0	1	2551	1132	40	1		1	CACNA1B	9	140901299	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2486213	140901299	312132	189	29694											
TUBB8	347688	broad.mit.edu	37	chr10	93792	93792	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtggcgttgtagggctcCaccacggtgtccgacacctt	6	9	14	12	3	0	0	0	0	0	0	2	1	2	0	4	4	0	3	4	4	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:93792C>A	uc001ifi.2	-	4	540	c.540G>T	c.(538-540)GTG>GTT	p.V180V	TUBB8_uc009xhe.2_Silent_p.V143V|TUBB8_uc010pzs.1_Silent_p.V108V	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	180					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		TGTAGGGCTCCACCACGGTGT	0.517													21	71					1.06801e-11	3.33435e-11	1	0	A	93792	A	A	93792	2	1	163	1	0	0	0	0	0	0	0	1	16829	581	21	4		4	TUBB8	10	93792	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08		93792	135440955	190	29695											
FAM171A1	221061	broad.mit.edu	37	chr10	15255068	15255068	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggctccgagggggcatccGcagtccgtctggtcgtctcc	3	9	14	15	4	2	0	0	0	2	0	7	1	5	0	4	4	0	3	4	4	0	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:15255068G>A	uc001iob.2	-	8	2526	c.2519C>T	c.(2518-2520)GCG>GTG	p.A840V		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	840	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						GGGGGCATCCGCAGTCCGTCT	0.617													39	83					0	0	0	0	A	15255068	A	A	15255068	3	1	163	1	0	0	0	0	1	0	0	0	5518	1087	38	1	157	1	FAM171A1	10	15255068	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	15161276	15255068	120279679	191	29696											
CUBN	8029	broad.mit.edu	37	chr10	16994277	16994277	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcatttttgttacttacatGgaggttgcgcttgaatgatc	8	18	9	6	1	1	2	1	2	0	0	2	3	1	3	0	2	3	3	0	2	3	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:16994277G>C	uc001ioo.2	-	33	5019	c.4967C>G	c.(4966-4968)CCA>CGA	p.P1656R		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1656	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTACTTACATGGAGGTTGCGC	0.438													21	36					0	0	0	0	C	16994277	C	C	16994277	3	2	163	1	0	0	0	0	1	0	0	0	4068	1348	47	4	6044	4	CUBN	10	16994277	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1739209	16994277	118540470	192	29697											
CUBN	8029	broad.mit.edu	37	chr10	16996484	16996484	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgaggagacgatggggttagCcagctgctcccttccacacg	8	8	13	12	2	0	2	0	1	0	1	2	4	2	2	3	3	3	3	3	3	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:16996484C>A	uc001ioo.2	-	32	4811	c.4759G>T	c.(4759-4761)GCT>TCT	p.A1587S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1587	CUB 10.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGGGGTTAGCCAGCTGCTCC	0.532													29	43					4.59853e-10	1.39857e-09	1	0	A	16996484	A	A	16996484	3	1	163	1	0	0	0	0	1	0	0	0	4068	739	26	4	6256	4	CUBN	10	16996484	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2207	16996484	118538263	193	29698											
CUBN	8029	broad.mit.edu	37	chr10	17165686	17165686	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaaacctttttgtcaacAgtctgaaacaaaaacaggac	16	9	6	10	0	2	1	1	1	1	0	2	2	2	2	1	1	5	1	1	1	5	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:17165686A>T	uc001ioo.2	-	5	442	c.390T>A	c.(388-390)ACT>ACA	p.T130T		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	130					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTTTGTCAACAGTCTGAAACA	0.443													6	5					0	0	0	0	T	17165686	T	T	17165686	2	4	163	1	0	0	0	0	0	0	0	1	4068	175	7	5		5	CUBN	10	17165686	Silent	SNP	A	TCGA-CR-7398-01A-11D-2012-08	169202	17165686	118369061	194	29699											
GPR158	57512	broad.mit.edu	37	chr10	25886754	25886754	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatataaaagaaagaagatGatcacaaacaacccccacct	21	6	4	10	0	1	4	1	1	0	3	1	4	1	4	3	0	2	0	3	0	8	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:25886754G>T	uc001isj.2	+	11	2259	c.2199G>T	c.(2197-2199)ATG>ATT	p.M733I	GPR158_uc001isk.2_Missense_Mutation_p.M108I	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	733	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GAAAGAAGATGATCACAAACA	0.448													34	68					3.66082e-28	1.34649e-27	1	0	T	25886754	T	T	25886754	3	4	163	1	0	0	0	0	1	0	0	0	6701	1290	45	2	2241	2	GPR158	10	25886754	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	8721068	25886754	109647993	195	29700											
ZNF37A	7587	broad.mit.edu	37	chr10	38407754	38407754	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgtagtaaacgagggaaatTactctgggtgaagtcagaac	15	9	12	5	1	2	2	1	1	1	1	2	4	2	3	0	2	3	2	0	2	7	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:38407754T>G	uc001izk.2	+	8	2494	c.1675T>G	c.(1675-1677)TAC>GAC	p.Y559D	ZNF37A_uc001izl.2_Missense_Mutation_p.Y559D|ZNF37A_uc001izm.2_Missense_Mutation_p.Y559D	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	559						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						CGAGGGAAATTACTCTGGGTG	0.353													3	7					0	0	0	0	G	38407754	G	G	38407754	3	3	163	1	0	0	0	0	1	0	0	0	17939	1754	61	5	1689	5	ZNF37A	10	38407754	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	12521000	38407754	97126993	196	29701											
RBP3	5949	broad.mit.edu	37	chr10	48388466	48388466	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatacaggtgctggcggggCtctgcctcaaagaagtagga	11	7	15	8	1	2	1	1	0	1	1	2	3	2	2	1	5	3	3	1	5	5	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:48388466C>A	uc001jez.2	-	1	2526	c.2412G>T	c.(2410-2412)GAG>GAT	p.E804D		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	804	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GCTGGCGGGGCTCTGCCTCAA	0.627													8	8					0.00307968	0.0078289	1	0	A	48388466	A	A	48388466	3	1	163	1	0	0	0	0	1	0	0	0	13222	796	28	4	1347	4	RBP3	10	48388466	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	9980712	48388466	87146281	197	29702											
JMJD1C	221037	broad.mit.edu	37	chr10	64944479	64944479	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atattctggcaatggcagacTttttaaaagatcttcgtatc	12	15	7	7	1	2	2	0	0	2	2	4	2	2	2	0	2	0	3	0	2	5	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:64944479T>A	uc001jmn.2	-	21	7150	c.6850A>T	c.(6850-6852)AGT>TGT	p.S2284C	JMJD1C_uc001jml.2_Missense_Mutation_p.S2047C|JMJD1C_uc001jmm.2_Missense_Mutation_p.S1996C|JMJD1C_uc010qiq.1_Missense_Mutation_p.S2102C|JMJD1C_uc009xpi.2_Missense_Mutation_p.S2102C|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmo.2_Missense_Mutation_p.S191C	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	2284	JmjC.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					AATGGCAGACTTTTTAAAAGA	0.333													16	26					0	0	0	0	A	64944479	A	A	64944479	3	1	163	1	0	0	0	0	1	0	0	0	7989	1609	56	5	796	5	JMJD1C	10	64944479	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	16556013	64944479	70590268	198	29703											
C10orf35	219738	broad.mit.edu	37	chr10	71392595	71392595	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagggggtcctggcccccGccagcagcaggcaggtgcca	6	3	15	17	1	0	0	0	0	0	0	1	0	1	0	6	5	3	3	6	5	0	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:71392595G>T	uc001jpq.3	+	4	316	c.146G>T	c.(145-147)CGC>CTC	p.R49L		NM_145306	NP_660349	Q96D05	CJ035_HUMAN	hypothetical protein LOC219738	49						integral to membrane				ovary(1)|skin(1)	2						CCTGGCCCCCGCCAGCAGCAG	0.602													17	19					1.99824e-07	5.62661e-07	1	0	T	71392595	T	T	71392595	3	4	163	1	0	0	0	0	1	0	0	0	1609	1087	38	3	152	3	C10orf35	10	71392595	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	6448116	71392595	64142152	199	29704											
PCGF5	84333	broad.mit.edu	37	chr10	93011162	93011162	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctatctgtctagattgtttaCgaaataatgggcaatcaggg	12	13	10	6	1	3	1	1	0	2	1	3	2	3	1	0	2	1	2	0	2	6	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:93011162C>G	uc001khh.2	+	6	686	c.439C>G	c.(439-441)CGA>GGA	p.R147G	PCGF5_uc010qnk.1_Missense_Mutation_p.R147G|PCGF5_uc001khi.2_Missense_Mutation_p.R147G	NM_032373	NP_115749	Q86SE9	PCGF5_HUMAN	polycomb group ring finger 5	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|PcG protein complex	zinc ion binding			lung(1)	1						AGATTGTTTACGAAATAATGG	0.343													16	30					0	0	0	0	G	93011162	G	G	93011162	3	3	163	1	0	0	0	0	1	0	0	0	11631	528	19	3	457	3	PCGF5	10	93011162	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	21618567	93011162	42523585	200	29705											
HPSE2	60495	broad.mit.edu	37	chr10	100401623	100401623	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttctgaattttcctaatcTggtcagagagtgtgtctaac	9	16	8	8	0	4	2	1	1	3	1	5	3	5	2	1	1	1	0	1	1	3	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:100401623T>A	uc001kpn.1	-	7	1139	c.1079A>T	c.(1078-1080)CAG>CTG	p.Q360L	HPSE2_uc009xwc.1_Missense_Mutation_p.Q350L|HPSE2_uc001kpo.1_Missense_Mutation_p.Q292L|HPSE2_uc009xwd.1_Missense_Mutation_p.Q238L	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	360					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TTTCCTAATCTGGTCAGAGAG	0.428													69	107					0	0	0	0	A	100401623	A	A	100401623	3	1	163	1	0	0	0	0	1	0	0	0	7384	1580	55	5	761	5	HPSE2	10	100401623	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	7390461	100401623	35133124	201	29706											
HPSE2	60495	broad.mit.edu	37	chr10	100481443	100481443	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcgatgacattcttcctCggccgcccaatattagggcc	8	9	11	13	3	1	1	0	1	1	0	3	2	2	1	4	3	0	0	4	3	3	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:100481443C>A	uc001kpn.1	-	5	987	c.927G>T	c.(925-927)CCG>CCT	p.P309P	HPSE2_uc009xwc.1_Silent_p.P299P|HPSE2_uc001kpo.1_Silent_p.P241P|HPSE2_uc009xwd.1_Silent_p.P187P	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	309					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		CATTCTTCCTCGGCCGCCCAA	0.438													14	31					0.000151284	0.000396574	1	0	A	100481443	A	A	100481443	2	1	163	1	0	0	0	0	0	0	0	1	7384	871	31	3		3	HPSE2	10	100481443	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	79820	100481443	35053304	202	29707											
SORCS3	22986	broad.mit.edu	37	chr10	107016579	107016579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctgttcttctttccaagctCcattggtggactccagtgct	5	16	8	12	0	3	0	0	0	3	0	6	1	6	1	3	2	2	3	3	2	1	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:107016579C>T	uc001kyi.1	+	25	3567	c.3340C>T	c.(3340-3342)CCA>TCA	p.P1114S		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1114	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TTTCCAAGCTCCATTGGTGGA	0.458													16	10					0	0	0	0	T	107016579	T	T	107016579	3	4	163	1	0	0	0	0	1	0	0	0	14996	855	30	2	3438	2	SORCS3	10	107016579	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	6535136	107016579	28518168	203	29708											
SORCS1	114815	broad.mit.edu	37	chr10	108923992	108923992	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcgtgcagcaaccgccatgGatgccccagtgccccgagcc	8	4	12	17	3	0	0	0	0	0	0	0	2	0	1	7	1	7	2	7	1	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:108923992G>T	uc001kym.2	-	1	301	c.293C>A	c.(292-294)TCC>TAC	p.S98Y	SORCS1_uc001kyl.2_Missense_Mutation_p.S98Y|SORCS1_uc009xxs.2_Missense_Mutation_p.S98Y|SORCS1_uc001kyn.1_Missense_Mutation_p.S98Y|SORCS1_uc001kyo.2_Missense_Mutation_p.S98Y	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	98	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AACCGCCATGGATGCCCCAGT	0.726													10	18					1.76689e-08	5.10967e-08	1	0	T	108923992	T	T	108923992	3	4	163	1	0	0	0	0	1	0	0	0	14994	1174	41	2	3551	2	SORCS1	10	108923992	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1907413	108923992	26610755	204	29709											
EMX2	2018	broad.mit.edu	37	chr10	119305325	119305325	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctcagcctcacggaaactCaggtgactgcggcccgggcg	7	5	14	15	4	3	1	3	1	0	0	3	2	3	2	3	4	3	0	3	4	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:119305325C>G	uc001ldh.3	+	2	1412	c.589C>G	c.(589-591)CAG>GAG	p.Q197E	EMX2OS_uc001ldg.2_5'Flank|EMX2_uc001ldi.3_Intron	NM_004098	NP_004089	Q04743	EMX2_HUMAN	empty spiracles homeobox 2 isoform 1	197	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		CACGGAAACTCAGGTGACTGC	0.632													5	17					0	0	0	0	G	119305325	G	G	119305325	3	3	163	1	0	0	0	0	1	0	0	0	5132	827	29	2	595	2	EMX2	10	119305325	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	10381333	119305325	16229422	205	29710											
MKI67	4288	broad.mit.edu	37	chr10	129913444	129913444	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctggcttagtggcagagtCagctgcatcttcaactttag	8	14	10	9	0	4	1	2	0	2	1	4	1	4	1	0	2	3	4	0	2	3	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:129913444C>T	uc001lke.2	-	7	1423	c.1228G>A	c.(1228-1230)GAC>AAC	p.D410N	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	410					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTGGCAGAGTCAGCTGCATCT	0.438													32	58					0	0	0	0	T	129913444	T	T	129913444	3	4	163	1	0	0	0	0	1	0	0	0	9651	826	29	2	8578	2	MKI67	10	129913444	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	10608119	129913444	5621303	206	29711											
MGMT	4255	broad.mit.edu	37	chr10	131557583	131557583	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caaagccgcgcgagcagtggGaggagcaatgagaggcaatc	13	3	16	9	3	0	1	0	1	0	1	1	5	0	3	1	3	3	3	1	3	3	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:131557583G>C	uc001lkh.2	+	4	511	c.485G>C	c.(484-486)GGA>GCA	p.G162A		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	131										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		CGAGCAGTGGGAGGAGCAATG	0.562								Direct_reversal_of_damage					23	40					0	0	0	0	C	131557583	C	C	131557583	3	2	163	1	0	0	0	0	1	0	0	0	9610	1174	41	2	499	2	MGMT	10	131557583	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1644139	131557583	3977164	207	29712											
TUBGCP2	10844	broad.mit.edu	37	chr10	135106020	135106020	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctgtatgggtcgtggatGatgcccctgtagatccactt	7	13	11	10	1	0	2	0	1	0	1	2	3	1	3	4	2	2	2	4	2	3	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:135106020G>A	uc001lmg.1	-	8	1554	c.1197C>T	c.(1195-1197)ATC>ATT	p.I399I	TUBGCP2_uc001lmf.1_5'Flank|TUBGCP2_uc010qvc.1_Silent_p.I427I|TUBGCP2_uc009ybk.1_Silent_p.I399I|TUBGCP2_uc010qvd.1_Silent_p.I269I|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	399					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		GGTCGTGGATGATGCCCCTGT	0.438													8	19					0	0	0	0	A	135106020	A	A	135106020	2	1	163	1	0	0	0	0	0	0	0	1	16834	1280	45	2		2	TUBGCP2	10	135106020	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	3548437	135106020	428727	208	29713											
FRG2B	441581	broad.mit.edu	37	chr10	135440184	135440184	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatctgttggaaagggggCtggtcagtggagcactggat	9	9	18	5	0	2	1	1	0	1	1	2	5	2	4	0	6	1	3	0	6	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr10:135440184C>A	uc010qvg.1	-	1	116	c.63G>T	c.(61-63)CAG>CAT	p.Q21H		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	21						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GGAAAGGGGGCTGGTCAGTGG	0.507													15	170					5.03518e-11	1.55958e-10	1	0	A	135440184	A	A	135440184	3	1	163	1	0	0	0	0	1	0	0	0	6081	796	28	4	788	4	FRG2B	10	135440184	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	334164	135440184	94563	209	29714											
KRTAP5-3	387266	broad.mit.edu	37	chr11	1629194	1629195	+	Missense_Mutation	DNP	CA	AG	AG																															actggcagcaggatgacccaCagcctgaggagcagcagcag																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:1629194_1629195CA>AG	uc001ltw.1	-	1	499_500	c.421_422TG>CT	c.(421-423)TGT>CTT	p.C141L		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	141	11 X 4 AA repeats of C-C-X-P.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		GGATGACCCACAGCCTGAGGAG	0.53													97	150					0	0	0	0	AG	1629195	AG	AG	1629194	3	1	163	1	0	0	0	0	1	0	0	0	8602	478	17	4	298	4	KRTAP5-3	11	1629194	Missense_Mutation	DNP	CA	TCGA-CR-7398-01A-11D-2012-08		1629194	133377322	210	29715											
TRIM68	55128	broad.mit.edu	37	chr11	4621792	4621792	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccttatcacccagaatccaTagtggggggataagtagacc	12	8	11	10	0	1	2	1	0	0	2	2	3	2	3	4	3	0	1	4	3	5	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:4621792T>C	uc001lzf.1	-	7	1410	c.1172A>G	c.(1171-1173)TAT>TGT	p.Y391C	TRIM68_uc001lzg.1_Missense_Mutation_p.Y168C|TRIM68_uc010qyj.1_RNA	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	391	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCAGAATCCATAGTGGGGGGA	0.572													18	35					0	0	0	0	C	4621792	C	C	4621792	3	2	163	1	0	0	0	0	1	0	0	0	16608	1406	49	5	289	5	TRIM68	11	4621792	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	2992598	4621792	130384724	211	29716											
TRIM22	10346	broad.mit.edu	37	chr11	5730671	5730671	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctcttctgatcccaaGgttttgactctctttatggc	5	17	6	13	0	3	2	0	2	3	0	7	2	6	2	3	2	0	1	3	2	2	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:5730671G>A	uc001mbr.2	+	8	1567	c.1290G>A	c.(1288-1290)AAG>AAA	p.K430K	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.2_Silent_p.K426K|TRIM22_uc010qzm.1_Silent_p.K258K|TRIM22_uc009yeu.2_Silent_p.K241K|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	430	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		CTGATCCCAAGGTTTTGACTC	0.423													44	80					0	0	0	0	A	5730671	A	A	5730671	2	1	163	1	0	0	0	0	0	0	0	1	16563	991	35	4		4	TRIM22	11	5730671	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1108879	5730671	129275845	212	29717											
OR52E4	390081	broad.mit.edu	37	chr11	5905604	5905604	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactggacactttacatatcTggatttctttcccattctgt	8	17	6	10	0	3	0	0	0	3	0	4	3	4	2	1	2	1	0	1	2	2	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:5905604T>A	uc010qzs.1	+	1	82	c.82T>A	c.(82-84)TGG>AGG	p.W28R	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTTACATATCTGGATTTCTTT	0.443													80	117					0	0	0	0	A	5905604	A	A	5905604	3	1	163	1	0	0	0	0	1	0	0	0	11170	1580	55	5	84	5	OR52E4	11	5905604	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	174933	5905604	129100912	213	29718											
NLRP14	338323	broad.mit.edu	37	chr11	7068026	7068026	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgaatatcctgcatcatGaactaaggcacccaaactgt	15	9	6	11	0	1	2	1	2	0	0	2	2	2	2	2	1	3	2	2	1	6	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:7068026G>T	uc001mfb.1	+	5	2409	c.2086G>T	c.(2086-2088)GAA>TAA	p.E696*		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	696					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CCTGCATCATGAACTAAGGCA	0.373													36	59					1.36161e-19	4.63185e-19	1	0	T	7068026	T	T	7068026	4	4	163	1	0	0	0	0	0	1	0	0	10530	1291	45	2	2100	2	NLRP14	11	7068026	Nonsense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1162422	7068026	127938490	214	29719											
INSC	387755	broad.mit.edu	37	chr11	15260557	15260557	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcgagtccagcagaaagctGcagtgaccctggctcgtctc	9	7	12	13	2	1	2	0	1	1	1	4	3	2	2	2	1	4	4	2	1	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:15260557G>C	uc001mly.2	+	11	1517	c.1471G>C	c.(1471-1473)GCA>CCA	p.A491P	INSC_uc001mlz.2_Missense_Mutation_p.A444P|INSC_uc001mma.2_Missense_Mutation_p.A444P|INSC_uc010rcs.1_Missense_Mutation_p.A479P|INSC_uc001mmb.2_Missense_Mutation_p.A444P|INSC_uc001mmc.2_Missense_Mutation_p.A402P	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	491					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						GCAGAAAGCTGCAGTGACCCT	0.607													14	27					0	0	0	0	C	15260557	C	C	15260557	3	2	163	1	0	0	0	0	1	0	0	0	7803	1319	46	4	1513	4	INSC	11	15260557	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	8192531	15260557	119745959	215	29720											
DBX1	120237	broad.mit.edu	37	chr11	20178181	20178181	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcagatcaggggctccggggGacgcacgggggcggggagtg	6	4	22	9	4	2	1	2	0	0	1	3	3	3	3	1	8	0	2	1	8	0	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:20178181G>A	uc001mpw.1	-	4	728	c.728C>T	c.(727-729)TCC>TTC	p.S243F		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCTCCGGGGGACGCACGGGG	0.627													24	43					0	0	0	0	A	20178181	A	A	20178181	3	1	163	1	0	0	0	0	1	0	0	0	4276	1174	41	2	424	2	DBX1	11	20178181	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	4917624	20178181	114828335	216	29721											
LRRC4C	57689	broad.mit.edu	37	chr11	40137513	40137513	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atttcaatggttctgatatgGttcctactcaactgtaggat	10	16	8	7	0	3	1	2	1	1	0	4	2	4	2	1	3	2	3	1	3	5	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:40137513G>T	uc001mxa.1	-	2	2294	c.330C>A	c.(328-330)AAC>AAA	p.N110K	LRRC4C_uc001mxc.1_Missense_Mutation_p.N106K|LRRC4C_uc001mxd.1_Missense_Mutation_p.N106K|LRRC4C_uc001mxb.1_Missense_Mutation_p.N106K	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	110	LRR 2.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TTCTGATATGGTTCCTACTCA	0.453													24	27					1.9806e-07	5.59032e-07	1	0	T	40137513	T	T	40137513	3	4	163	1	0	0	0	0	1	0	0	0	9058	1252	44	4	1596	4	LRRC4C	11	40137513	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	19959332	40137513	94869003	217	29722											
OR4A5	81318	broad.mit.edu	37	chr11	51411675	51411675	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaggacaacaacggtacTgccggagctgcaggtagaca	15	4	13	9	2	0	2	0	0	0	2	0	4	0	4	1	4	6	4	1	4	5	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:51411675T>A	uc001nhi.1	-	1	721	c.721A>T	c.(721-723)AGT>TGT	p.S241C		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				ACAACGGTACTGCCGGAGCTG	0.398													18	25					0	0	0	0	A	51411675	A	A	51411675	3	1	163	1	0	0	0	0	1	0	0	0	11097	1580	55	5	230	5	OR4A5	11	51411675	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	11274162	51411675	83594841	218	29723											
OR5L1	219437	broad.mit.edu	37	chr11	55579555	55579555	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctgttcctggtggccactTtgaatgagagtgttaccatc	7	14	11	9	0	0	2	0	2	0	1	2	3	1	2	3	2	2	3	3	2	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:55579555T>A	uc001nhw.1	+	1	613	c.613T>A	c.(613-615)TTG>ATG	p.L205M		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				GGTGGCCACTTTGAATGAGAG	0.463													48	101					0	0	0	0	A	55579555	A	A	55579555	3	1	163	1	0	0	0	0	1	0	0	0	11224	1838	64	5	615	5	OR5L1	11	55579555	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	4167880	55579555	79426961	219	29724											
OR8K5	219453	broad.mit.edu	37	chr11	55927296	55927296	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattagagccacagaaggtCaatgtaaaaatcttaatagt	18	10	7	6	0	2	2	1	0	1	2	2	2	2	2	1	1	1	1	1	1	8	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:55927296C>A	uc010rja.1	-	1	498	c.498G>T	c.(496-498)TTG>TTT	p.L166F		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				CACAGAAGGTCAATGTAAAAA	0.383													21	55					2.27731e-05	6.10567e-05	1	0	A	55927296	A	A	55927296	3	1	163	1	0	0	0	0	1	0	0	0	11299	825	29	2	428	2	OR8K5	11	55927296	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	347741	55927296	79079220	220	29725											
OR8K5	219453	broad.mit.edu	37	chr11	55927362	55927362	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagagatattgaatgcccacCagtacatgacacagtcgctg	13	9	9	10	1	0	3	0	2	0	1	1	4	0	3	2	0	2	2	2	0	4	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:55927362C>G	uc010rja.1	-	1	432	c.432G>C	c.(430-432)CTG>CTC	p.L144L		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				GAATGCCCACCAGTACATGAC	0.403													32	71					0	0	0	0	G	55927362	G	G	55927362	2	3	163	1	0	0	0	0	0	0	0	1	11299	581	21	4		4	OR8K5	11	55927362	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	66	55927362	79079154	221	29726											
OR8K3	219473	broad.mit.edu	37	chr11	56086244	56086244	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttacctctattgcacattCatttctcttctagtcaccat	8	17	2	14	0	5	0	2	0	3	0	6	0	5	0	3	0	2	1	3	0	3	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:56086244C>A	uc010rjf.1	+	1	462	c.462C>A	c.(460-462)TTC>TTA	p.F154L		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					ATTGCACATTCATTTCTCTTC	0.418													45	64					7.05121e-23	2.49228e-22	1	0	A	56086244	A	A	56086244	3	1	163	1	0	0	0	0	1	0	0	0	11298	825	29	2	464	2	OR8K3	11	56086244	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	158882	56086244	78920272	222	29727											
OR9G4	283189	broad.mit.edu	37	chr11	56511027	56511027	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggggtatacacagaggtataCcagaaatccaaaaaagacag	19	5	10	7	0	0	3	0	0	0	3	1	3	1	3	2	3	2	2	2	3	8	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:56511027C>A	uc010rjo.1	-	1	261	c.261G>T	c.(259-261)TGG>TGT	p.W87C		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	87	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CAGAGGTATACCAGAAATCCA	0.433													34	63					6.90743e-12	2.16801e-11	1	0	A	56511027	A	A	56511027	3	1	163	1	0	0	0	0	1	0	0	0	11305	508	18	4	725	4	OR9G4	11	56511027	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	424783	56511027	78495489	223	29728											
ZFP91	80829	broad.mit.edu	37	chr11	58384258	58384258	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacaatctggcagtgcaccGgatgattcacactggcgaga	11	7	11	12	2	2	2	1	1	1	1	2	4	2	3	2	3	1	2	2	3	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:58384258G>A	uc001nmx.3	+	10	1340	c.1172G>A	c.(1171-1173)CGG>CAG	p.R391Q	ZFP91_uc001nmy.3_Missense_Mutation_p.R390Q|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	391	C2H2-type 3.				activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				GCAGTGCACCGGATGATTCAC	0.428													13	47					0	0	0	0	A	58384258	A	A	58384258	3	1	163	1	0	0	0	0	1	0	0	0	17722	1116	39	1	1210	1	ZFP91	11	58384258	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1873231	58384258	76622258	224	29729											
GLYAT	10249	broad.mit.edu	37	chr11	58491896	58491896	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tttccattatcacctttaagGatgctgggaggctcttcctc	7	15	8	11	0	2	0	1	0	1	0	5	2	4	2	3	3	1	2	3	3	2	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:58491896G>A	uc001nnb.2	-	2	229	c.74C>T	c.(73-75)TCC>TTC	p.S25F	GLYAT_uc001nnc.2_Missense_Mutation_p.S25F	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	25					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	CACCTTTAAGGATGCTGGGAG	0.398													50	82					0	0	0	0	A	58491896	A	A	58491896	3	1	163	1	0	0	0	0	1	0	0	0	6516	1174	41	2	840	2	GLYAT	11	58491896	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	107638	58491896	76514620	225	29730											
TCN1	6947	broad.mit.edu	37	chr11	59622199	59622199	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaccatttagcacagtgacAttggtgaaatatgtttcatt	13	14	8	6	0	1	2	1	2	0	0	1	3	1	2	1	1	2	2	1	1	4	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:59622199A>G	uc001noj.2	-	7	1145	c.1047T>C	c.(1045-1047)AAT>AAC	p.N349N		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	349					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCACAGTGACATTGGTGAAAT	0.403													36	59					0	0	0	0	G	59622199	G	G	59622199	2	3	163	1	0	0	0	0	0	0	0	1	15772	214	8	5		5	TCN1	11	59622199	Silent	SNP	A	TCGA-CR-7398-01A-11D-2012-08	1130303	59622199	75384317	226	29731											
MS4A14	84689	broad.mit.edu	37	chr11	60183525	60183525	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccccctcaaggcatactaTcccaagacacatcatctcaa	13	8	4	16	0	3	1	3	0	1	1	5	1	4	1	3	1	2	1	3	1	5	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:60183525T>A	uc001npj.2	+	5	1649	c.1084T>A	c.(1084-1086)TCC>ACC	p.S362T	MS4A14_uc001npi.2_Missense_Mutation_p.S250T|MS4A14_uc001npn.2_Missense_Mutation_p.S100T|MS4A14_uc001npk.2_Missense_Mutation_p.S345T|MS4A14_uc001npl.2_Missense_Mutation_p.S100T|MS4A14_uc001npm.2_Missense_Mutation_p.S100T	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	362						integral to membrane	receptor activity			breast(1)	1						AGGcatactatcccaagacac	0.219													14	14					0	0	0	0	A	60183525	A	A	60183525	3	1	163	1	0	0	0	0	1	0	0	0	9911	1435	50	5	1102	5	MS4A14	11	60183525	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	561326	60183525	74822991	227	29732											
ASRGL1	80150	broad.mit.edu	37	chr11	62124564	62124564	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgacagagagaaacaaaaagCgcctggaaaaagagaagcat	21	3	11	6	1	0	4	0	1	0	3	0	7	0	5	1	1	3	1	1	1	6	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:62124564C>T	uc001nte.3	+	4	723	c.439C>T	c.(439-441)CGC>TGC	p.R147C	ASRGL1_uc001ntf.3_Missense_Mutation_p.R147C|ASRGL1_uc001ntg.3_Missense_Mutation_p.R19C|ASRGL1_uc001nth.1_RNA	NM_025080	NP_079356	Q7L266	ASGL1_HUMAN	asparaginase-like 1	147					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	AAACAAAAAGCGCCTGGAAAA	0.433													17	28					0	0	0	0	T	62124564	T	T	62124564	3	4	163	1	0	0	0	0	1	0	0	0	1062	768	27	1	449	1	ASRGL1	11	62124564	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1941039	62124564	72881952	228	29733											
SF1	7536	broad.mit.edu	37	chr11	64536570	64536570	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtgttggtaatgctgcGggtctctgagctctgccagg	4	13	16	8	1	2	1	0	1	2	0	3	1	2	1	1	4	4	4	1	4	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:64536570G>T	uc001obb.1	-	8	1188	c.811C>A	c.(811-813)CGC>AGC	p.R271S	SF1_uc010rnm.1_5'UTR|SF1_uc010rnn.1_Missense_Mutation_p.R245S|SF1_uc001oaz.1_Missense_Mutation_p.R396S|SF1_uc001oba.1_Missense_Mutation_p.R271S|SF1_uc001obc.1_Missense_Mutation_p.R271S|SF1_uc001obd.1_Missense_Mutation_p.R271S|SF1_uc001obe.1_Missense_Mutation_p.R156S|SF1_uc010rno.1_Missense_Mutation_p.R156S	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	271					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						GTAATGCTGCGGGTCTCTGAG	0.488													5	212					0.00198382	0.00507599	1	0	T	64536570	T	T	64536570	3	4	163	1	0	0	0	0	1	0	0	0	14210	1116	39	3	1270	3	SF1	11	64536570	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2412006	64536570	70469946	229	29734											
EFEMP2	30008	broad.mit.edu	37	chr11	65637634	65637634	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccccagctggaagcccggctCgcactggcagcggaaggagc	8	3	15	15	3	0	0	0	0	0	0	1	3	0	3	3	5	4	4	3	5	2	0	rs148940436		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:65637634C>T	uc001ofy.3	-	6	759	c.565G>A	c.(565-567)GAG>AAG	p.E189K	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.E189K	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	189	EGF-like 3; calcium-binding (Potential).				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		AAGCCCGGCTCGCACTGGCAG	0.667													22	31					0	0	0	0	T	65637634	T	T	65637634	3	4	163	1	0	0	0	0	1	0	0	0	4964	893	31	1	790	1	EFEMP2	11	65637634	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1101064	65637634	69368882	230	29735											
RBM4	5936	broad.mit.edu	37	chr11	66407340	66407340	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcagctgaggatgccatacGcaacctgcaccattacaagc	12	6	10	13	1	0	1	0	1	0	0	0	2	0	2	3	2	7	4	3	2	4	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:66407340G>A	uc009yrj.2	+	2	646	c.158G>A	c.(157-159)CGC>CAC	p.R53H	RBM4_uc009yrk.2_Intron|RBM4_uc001oiv.2_Missense_Mutation_p.R53H|RBM4_uc001oiw.1_Missense_Mutation_p.R53H|RBM4_uc001oix.1_Missense_Mutation_p.R53H|RBM4_uc010rpj.1_Missense_Mutation_p.R53H|RBM4_uc001oiy.1_Missense_Mutation_p.R53H|RBM4_uc001oiz.1_Missense_Mutation_p.R53H	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	53	RRM 1.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		GATGCCATACGCAACCTGCAC	0.468													58	116					0	0	0	0	A	66407340	A	A	66407340	3	1	163	1	0	0	0	0	1	0	0	0	13199	1087	38	1	160	1	RBM4	11	66407340	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	769706	66407340	68599176	231	29736											
ANO1	55107	broad.mit.edu	37	chr11	70033950	70033950	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctcatggtggagctgtTcatgcgggaggagcaagaca	9	8	17	7	1	2	1	2	0	0	1	2	4	2	4	0	5	4	4	0	5	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:70033950T>A	uc001opj.2	+	26	3106	c.2801T>A	c.(2800-2802)TTC>TAC	p.F934Y	ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.F643Y|ANO1_uc010rql.1_Missense_Mutation_p.F108Y	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	934	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						GTGGAGCTGTTCATGCGGGAG	0.577													6	4					0	0	0	0	A	70033950	A	A	70033950	3	1	163	1	0	0	0	0	1	0	0	0	695	1783	62	5	2903	5	ANO1	11	70033950	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	3626610	70033950	64972566	232	29737											
MYO7A	4647	broad.mit.edu	37	chr11	76870542	76870542	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggttctcttctccccatcGctggccacagctgcatccct	5	11	8	17	1	2	0	0	0	2	0	6	1	3	0	4	2	2	4	4	2	0	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:76870542G>C	uc001oyb.2	+	10	1325	c.1053G>C	c.(1051-1053)TCG>TCC	p.S351S	MYO7A_uc010rsl.1_Silent_p.S351S|MYO7A_uc010rsm.1_Silent_p.S340S|MYO7A_uc001oyc.2_Silent_p.S351S	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	351	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						TCTCCCCATCGCTGGCCACAG	0.587													33	42					0	0	0	0	C	76870542	C	C	76870542	2	2	163	1	0	0	0	0	0	0	0	1	10135	1074	38	3		3	MYO7A	11	76870542	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	6836592	76870542	58135974	233	29738											
SLC36A4	120103	broad.mit.edu	37	chr11	92895879	92895879	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catatacacctaccatacatCttggggaagatttaaagtta	15	12	6	8	0	1	1	0	0	1	1	1	2	1	2	2	2	3	1	2	2	8	8	rs76610702	byFrequency	TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:92895879C>A	uc001pdn.2	-	9	1127	c.1030G>T	c.(1030-1032)GAT>TAT	p.D344Y	SLC36A4_uc001pdm.2_Missense_Mutation_p.D209Y	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid	344					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TACCATACATCTTGGGGAAGA	0.303													21	23					2.4624e-09	7.39347e-09	1	0	A	92895879	A	A	92895879	3	1	163	1	0	0	0	0	1	0	0	0	14660	913	32	2	496	2	SLC36A4	11	92895879	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	16025337	92895879	42110637	234	29739											
KIAA1377	57562	broad.mit.edu	37	chr11	101832914	101832914	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttgtactagataaaaaatGtgaaaagacctctgaaacta	18	11	7	5	0	1	4	0	2	1	2	1	4	1	4	1	0	2	2	1	0	9	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:101832914G>T	uc001pgm.2	+	6	1418	c.1148G>T	c.(1147-1149)TGT>TTT	p.C383F	KIAA1377_uc001pgn.2_Missense_Mutation_p.C339F|KIAA1377_uc010run.1_Missense_Mutation_p.C184F|KIAA1377_uc009yxa.1_Missense_Mutation_p.C184F	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	383							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GATAAAAAATGTGAAAAGACC	0.398													15	29					0.000308642	0.000801924	1	0	T	101832914	T	T	101832914	3	4	163	1	0	0	0	0	1	0	0	0	8266	1377	48	4	1170	4	KIAA1377	11	101832914	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	8937035	101832914	33173602	235	29740											
GRIA4	2893	broad.mit.edu	37	chr11	105795455	105795455	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaacagcctctggttttccCtgggtgcttttatgcagcaa	7	15	9	10	0	1	0	0	0	1	0	2	0	2	0	2	2	5	4	2	2	3	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:105795455C>T	uc001pix.2	+	12	2253	c.1807C>T	c.(1807-1809)CTG>TTG	p.L603L	GRIA4_uc001piw.2_Silent_p.L603L	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	603	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	CTGGTTTTCCCTGGGTGCTTT	0.463													25	29					0	0	0	0	T	105795455	T	T	105795455	2	4	163	1	0	0	0	0	0	0	0	1	6809	680	24	4		4	GRIA4	11	105795455	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	3962541	105795455	29211061	236	29741											
ZW10	9183	broad.mit.edu	37	chr11	113614600	113614600	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcttcacagactcactgaTacggcatgtgggcaaggaaa	12	10	10	9	1	3	2	2	1	1	1	3	3	3	3	0	3	1	2	0	3	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:113614600T>C	uc001poe.2	-	10	1472	c.1435A>G	c.(1435-1437)ATC>GTC	p.I479V	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	479					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		GACTCACTGATACGGCATGTG	0.413													30	56					0	0	0	0	C	113614600	C	C	113614600	3	2	163	1	0	0	0	0	1	0	0	0	18314	1406	49	5	932	5	ZW10	11	113614600	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	7819145	113614600	21391916	237	29742											
ZBTB16	7704	broad.mit.edu	37	chr11	114027108	114027108	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtgcgagctctgcgggaagCggttcctggatagtttgcgg	5	10	18	8	4	1	0	0	0	1	0	2	3	2	2	1	5	5	3	1	5	2	3	rs141621748		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:114027108C>A	uc001pop.2	+	3	1582	c.1318C>A	c.(1318-1320)CGG>AGG	p.R440R	ZBTB16_uc001poo.1_Silent_p.R440R|ZBTB16_uc001poq.2_Silent_p.R440R	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	440	C2H2-type 2.				apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		CTGCGGGAAGCGGTTCCTGGA	0.552													18	47					0.000958276	0.00246264	1	0	A	114027108	A	A	114027108	2	1	163	1	0	0	0	0	0	0	0	1	17593	759	27	3		3	ZBTB16	11	114027108	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	412508	114027108	20979408	238	29743											
PCSK7	9159	broad.mit.edu	37	chr11	117093951	117093951	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaagcatcttgtccccaccActgaaggtgactgccagcat	10	8	9	14	1	1	2	0	2	1	0	2	3	2	2	4	1	3	2	4	1	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:117093951A>C	uc001pqr.2	-	9	1329	c.1128T>G	c.(1126-1128)AGT>AGG	p.S376R		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	376	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		TGTCCCCACCACTGAAGGTGA	0.577			T	IGH@	MLCLS								42	57					0	0	0	0	C	117093951	C	C	117093951	3	2	163	1	0	0	0	0	1	0	0	0	11659	156	6	5	1265	5	PCSK7	11	117093951	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	3066843	117093951	17912565	239	29744											
TECTA	7007	broad.mit.edu	37	chr11	121032985	121032985	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacggctgctacagccacaaGaagttccagctgtgcggctc	9	7	12	13	2	0	1	0	0	0	1	2	2	1	1	2	2	5	5	2	2	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:121032985G>T	uc010rzo.1	+	15	5178	c.5178G>T	c.(5176-5178)AAG>AAT	p.K1726N		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1726					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ACAGCCACAAGAAGTTCCAGC	0.592													21	37					1.00905e-13	3.2361e-13	1	0	T	121032985	T	T	121032985	3	4	163	1	0	0	0	0	1	0	0	0	15813	933	33	2	5236	2	TECTA	11	121032985	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	3939034	121032985	13973531	240	29745											
OR8B12	219858	broad.mit.edu	37	chr11	124413188	124413188	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttacagatggccacgtaGcggtcatacgccatcgctga	9	8	13	11	4	1	2	1	1	0	1	2	2	1	2	2	3	3	3	2	3	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:124413188G>C	uc010sam.1	-	1	363	c.363C>G	c.(361-363)CGC>CGG	p.R121R		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		TGGCCACGTAGCGGTCATACG	0.507													23	49					0	0	0	0	C	124413188	C	C	124413188	2	2	163	1	0	0	0	0	0	0	0	1	11280	958	34	4		4	OR8B12	11	124413188	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	3380203	124413188	10593328	241	29746											
KIRREL3	84623	broad.mit.edu	37	chr11	126343309	126343309	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaggttgagagggtccccCgcacgcaggctgatcacagg	8	6	16	11	2	1	3	1	3	0	1	2	4	2	3	2	4	0	4	2	4	0	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:126343309C>T	uc001qea.2	-	5	847	c.486G>A	c.(484-486)GCG>GCA	p.A162A	KIRREL3_uc001qeb.2_Silent_p.A162A|KIRREL3_uc001qec.1_Silent_p.A162A	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	162	Ig-like C2-type 2.|Extracellular (Potential).				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		GAGGGTCCCCCGCACGCAGGC	0.647													6	7					0	0	0	0	T	126343309	T	T	126343309	2	4	163	1	0	0	0	0	0	0	0	1	8365	639	23	1		1	KIRREL3	11	126343309	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1930121	126343309	8663207	242	29747											
ETS1	2113	broad.mit.edu	37	chr11	128360449	128360449	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctgcttggagttaatagTgggacatctgcacattccat	9	14	10	8	0	1	0	0	0	1	0	2	2	2	2	1	2	3	4	1	2	2	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:128360449T>A	uc010sbs.1	-	2	421	c.105A>T	c.(103-105)CCA>CCT	p.P35P	ETS1_uc001qej.2_Silent_p.P79P|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Silent_p.P35P	NM_005238	NP_005229	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	35					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		GAGTTAATAGTGGGACATCTG	0.358													15	17					0	0	0	0	A	128360449	A	A	128360449	2	1	163	1	0	0	0	0	0	0	0	1	5299	1683	59	5		5	ETS1	11	128360449	Silent	SNP	T	TCGA-CR-7398-01A-11D-2012-08	2017140	128360449	6646067	243	29748											
FLI1	2313	broad.mit.edu	37	chr11	128628193	128628193	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagtgagggtcaacgtcaagCgggagtatgaccacatgaat	13	7	13	8	2	2	3	2	3	0	0	2	4	2	4	1	2	2	1	1	2	4	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr11:128628193C>T	uc010sbu.1	+	2	543	c.202C>T	c.(202-204)CGG>TGG	p.R68W	FLI1_uc010sbt.1_5'UTR|FLI1_uc010sbv.1_Missense_Mutation_p.R35W|FLI1_uc009zci.2_5'UTR|FLI1_uc001qen.2_Missense_Mutation_p.R35W	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	68					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R68W(1)	EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		CAACGTCAAGCGGGAGTATGA	0.587			T	EWSR1	Ewing sarcoma								8	17					0	0	0	0	T	128628193	T	T	128628193	3	4	163	1	0	0	0	0	1	0	0	0	5956	759	27	1	208	1	FLI1	11	128628193	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	267744	128628193	6378323	244	29749											
PARP11	57097	broad.mit.edu	37	chr12	3939117	3939117	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccccactgggtatctgacGtgtccatgtcatccacttca	8	11	8	14	1	3	1	2	1	1	0	5	1	5	1	4	1	1	1	4	1	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:3939117G>T	uc001qmk.1	-	1	120	c.65C>A	c.(64-66)ACG>AAG	p.T22K	PARP11_uc001qml.2_Missense_Mutation_p.T29K|PARP11_uc009zef.2_RNA|PARP11_uc001qmm.2_5'UTR|PARP11_uc001qmn.2_5'UTR	NM_020367	NP_065100	Q9NR21	PAR11_HUMAN	poly (ADP-ribose) polymerase family, member 11	22	WWE.						NAD+ ADP-ribosyltransferase activity			ovary(1)|central_nervous_system(1)	2			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)			GGTATCTGACGTGTCCATGTC	0.413													54	93					3.07002e-29	1.13988e-28	1	0	T	3939117	T	T	3939117	3	4	163	1	0	0	0	0	1	0	0	0	11510	1145	40	3	958	3	PARP11	12	3939117	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08		3939117	129912778	245	29750											
NTF3	4908	broad.mit.edu	37	chr12	5604005	5604005	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacggttgcaggggtattGatgataaacactggaactct	14	10	11	6	1	1	2	0	2	1	0	1	3	1	3	0	4	4	3	0	4	6	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:5604005G>T	uc001qnl.3	+	1	708	c.625G>T	c.(625-627)GAT>TAT	p.D209Y	NTF3_uc001qnk.3_Missense_Mutation_p.D222Y	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	209					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						CAGGGGTATTGATGATAAACA	0.488													99	46					2.31008e-40	8.94397e-40	1	0	T	5604005	T	T	5604005	3	4	163	1	0	0	0	0	1	0	0	0	10750	1290	45	2	670	2	NTF3	12	5604005	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1664888	5604005	128247890	246	29751											
TAS2R13	50838	broad.mit.edu	37	chr12	11061579	11061579	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actcgctattttgagcaaatAaaagatgctgaagattgtag	15	12	9	5	1	0	4	0	2	0	2	1	4	0	4	0	0	2	4	0	0	6	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:11061579A>G	uc001qzg.1	-	1	583	c.319T>C	c.(319-321)TAT>CAT	p.Y107H	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron	NM_023920	NP_076409	Q9NYV9	T2R13_HUMAN	taste receptor, type 2, member 13	107	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|skin(1)	2						TTGAGCAAATAAAAGATGCTG	0.368													77	33					0	0	0	0	G	11061579	G	G	11061579	3	3	163	1	0	0	0	0	1	0	0	0	15633	362	13	5	596	5	TAS2R13	12	11061579	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	5457574	11061579	122790316	247	29752											
PRB2	653247	broad.mit.edu	37	chr12	11546829	11546829	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggctggttgcctccttgtggGggtggtccttgtggctttcc	0	15	16	10	0	0	0	0	0	0	0	3	0	3	0	4	6	1	3	4	6	0	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:11546829G>T	uc010shk.1	-	3	218	c.183C>A	c.(181-183)CCC>CCA	p.P61P		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTCCTTGTGGGGGTGGTCCTT	0.587													12	687					0.00074312	0.0019181	1	0	T	11546829	T	T	11546829	2	4	163	1	0	0	0	0	0	0	0	1	12505	1219	43	4		4	PRB2	12	11546829	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	485250	11546829	122305066	248	29753											
KIAA1467	57613	broad.mit.edu	37	chr12	13224192	13224192	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagatgatggttgtggatggTgactctggctccattgtttg	6	16	14	5	0	1	3	0	2	1	1	2	4	2	4	1	4	0	3	1	4	1	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:13224192T>A	uc001rbi.2	+	10	1409	c.1386T>A	c.(1384-1386)GGT>GGA	p.G462G	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	462						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TTGTGGATGGTGACTCTGGCT	0.478													90	247					0	0	0	0	A	13224192	A	A	13224192	2	1	163	1	0	0	0	0	0	0	0	1	8274	1683	59	5		5	KIAA1467	12	13224192	Silent	SNP	T	TCGA-CR-7398-01A-11D-2012-08	1677363	13224192	120627703	249	29754											
ART4	420	broad.mit.edu	37	chr12	14996007	14996007	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaggaggtacagtagttGggagaagaatcttcttgcat	11	12	13	5	0	2	2	0	0	2	2	2	4	2	3	0	3	3	5	0	3	4	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:14996007G>T	uc001rcl.1	-	1	407	c.41C>A	c.(40-42)CCA>CAA	p.P14Q	ART4_uc009zid.1_RNA|ART4_uc009zie.1_RNA|ART4_uc001rcm.1_Missense_Mutation_p.P14Q	NM_021071	NP_066549	Q93070	NAR4_HUMAN	ADP-ribosyltransferase 4 precursor	14					arginine metabolic process|protein ADP-ribosylation	anchored to membrane|plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity				0						TACAGTAGTTGGGAGAAGAAT	0.507													74	51					2.10938e-32	7.9575e-32	1	0	T	14996007	T	T	14996007	3	4	163	1	0	0	0	0	1	0	0	0	1001	1348	47	4	915	4	ART4	12	14996007	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1771815	14996007	118855888	250	29755											
PIK3C2G	5288	broad.mit.edu	37	chr12	18658284	18658284	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtggtaacattcatcctggGagtatgtgaccgtcacaatg	10	12	11	8	1	2	1	2	1	0	0	3	2	3	2	2	2	1	2	2	2	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:18658284G>T	uc001rdt.2	+	23	3205	c.3089G>T	c.(3088-3090)GGA>GTA	p.G1030V	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.G1071V|PIK3C2G_uc010sic.1_Missense_Mutation_p.G849V	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1030	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				TTCATCCTGGGAGTATGTGAC	0.383													22	16					4.35082e-09	1.29316e-08	1	0	T	18658284	T	T	18658284	3	4	163	1	0	0	0	0	1	0	0	0	11966	1174	41	2	3175	2	PIK3C2G	12	18658284	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	3662277	18658284	115193611	251	29756											
ITPR2	3709	broad.mit.edu	37	chr12	26580957	26580957	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaggcttggagaagaaaaaCagcatagatgtgcagatcgc	16	6	12	7	1	0	4	0	0	0	4	1	5	0	4	0	2	3	3	0	2	4	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:26580957C>A	uc001rhg.2	-	49	7251	c.6834G>T	c.(6832-6834)CTG>CTT	p.L2278L	ITPR2_uc009zjg.1_Silent_p.L429L	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2278	Helical; (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AGAAGAAAAACAGCATAGATG	0.383													18	66					4.35082e-09	1.29316e-08	1	0	A	26580957	A	A	26580957	2	1	163	1	0	0	0	0	0	0	0	1	7960	465	17	4		4	ITPR2	12	26580957	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	7922673	26580957	107270938	252	29757											
ZNF641	121274	broad.mit.edu	37	chr12	48738456	48738456	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccattgttcttctcctcctTctagttgagaaagcatgtcc	7	15	6	13	0	3	1	0	1	3	1	6	2	5	1	4	0	1	3	4	0	2	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:48738456T>C	uc001rrn.1	-	5	653	c.488A>G	c.(487-489)GAA>GGA	p.E163G	ZNF641_uc001rro.1_Missense_Mutation_p.E149G|ZNF641_uc010sls.1_Missense_Mutation_p.E140G	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641	163	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TTCTCCTCCTTCTAGTTGAGA	0.438													68	13					0	0	0	0	C	48738456	C	C	48738456	3	2	163	1	0	0	0	0	1	0	0	0	18124	1783	62	5	836	5	ZNF641	12	48738456	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	22157499	48738456	85113439	253	29758											
ESPL1	9700	broad.mit.edu	37	chr12	53683319	53683319	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttcagggctttggaatctgGccacttcccccagcctgaaa	8	10	9	14	0	2	1	1	1	1	0	3	2	3	2	4	3	1	1	4	3	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:53683319G>T	uc001sck.2	+	22	5145	c.5054G>T	c.(5053-5055)GGC>GTC	p.G1685V	ESPL1_uc001scj.2_Missense_Mutation_p.G1360V	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1685					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						TTGGAATCTGGCCACTTCCCC	0.612													51	14					5.57489e-27	2.03778e-26	1	0	T	53683319	T	T	53683319	3	4	163	1	0	0	0	0	1	0	0	0	5277	1203	42	4	5136	4	ESPL1	12	53683319	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	4944863	53683319	80168576	254	29759											
SLC16A7	9194	broad.mit.edu	37	chr12	60168919	60168919	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaggaattgatgagtactcGgcagcttttctgctatctgt	9	14	10	8	1	2	2	0	2	2	0	3	3	2	3	0	2	3	4	0	2	4	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:60168919G>T	uc001sqs.2	+	5	1142	c.843G>T	c.(841-843)TCG>TCT	p.S281S	SLC16A7_uc001sqt.2_Silent_p.S281S|SLC16A7_uc001squ.2_Silent_p.S281S|SLC16A7_uc009zqi.2_Silent_p.S182S|SLC16A7_uc010ssi.1_Silent_p.S182S	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	281	Extracellular (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	ATGAGTACTCGGCAGCTTTTC	0.383													78	16					9.63364e-24	3.436e-23	1	0	T	60168919	T	T	60168919	2	4	163	1	0	0	0	0	0	0	0	1	14478	1103	39	3		3	SLC16A7	12	60168919	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	6485600	60168919	73682976	255	29760											
SRGAP1	57522	broad.mit.edu	37	chr12	64472740	64472740	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accttgcagacgatacaagaTatggtcaccatcgaggacta	14	8	9	10	2	1	2	1	0	0	2	2	5	1	3	2	2	2	1	2	2	4	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:64472740T>C	uc010ssp.1	+	9	1223	c.1167T>C	c.(1165-1167)GAT>GAC	p.D389D	SRGAP1_uc001srt.2_Silent_p.D389D|SRGAP1_uc001srv.2_Silent_p.D349D	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	389	Potential.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CGATACAAGATATGGTCACCA	0.378													39	12					0	0	0	0	C	64472740	C	C	64472740	2	2	163	1	0	0	0	0	0	0	0	1	15211	1403	49	5		5	SRGAP1	12	64472740	Silent	SNP	T	TCGA-CR-7398-01A-11D-2012-08	4303821	64472740	69379155	256	29761											
TMTC3	160418	broad.mit.edu	37	chr12	88588735	88588735	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catggatgacaaaaaggacaAtgaagcagagatttggatga	18	7	12	4	0	0	4	0	3	0	1	0	8	0	7	0	3	1	1	0	3	4	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr12:88588735A>T	uc001tau.2	+	14	2274	c.2054A>T	c.(2053-2055)AAT>ATT	p.N685I		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	686	TPR 7.					integral to membrane	binding			skin(1)	1						AAAAAGGACAATGAAGCAGAG	0.398													35	13					0	0	0	0	T	88588735	T	T	88588735	3	4	163	1	0	0	0	0	1	0	0	0	16328	101	4	5	2104	5	TMTC3	12	88588735	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	24115995	88588735	45263160	257	29762											
MTUS2	23281	broad.mit.edu	37	chr13	29898764	29898764	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acacaggaacaaagaaagatGctcagaaagatcaagatacg	21	4	9	7	1	2	5	2	0	0	5	2	6	2	6	0	1	3	1	0	1	6	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr13:29898764G>T	uc001usl.3	+	5	2909	c.2851G>T	c.(2851-2853)GCT>TCT	p.A951S		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	941	Localization to the growing distal tip of microtubules.|Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity	p.A951T(1)			0						AAAGAAAGATGCTCAGAAAGA	0.378													6	0					2.0095e-06	5.51324e-06	1	0	T	29898764	T	T	29898764	3	4	163	1	0	0	0	0	1	0	0	0	10019	1319	46	4	2869	4	MTUS2	13	29898764	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08		29898764	85271114	258	29763											
RB1	5925	broad.mit.edu	37	chr13	48881512	48881512	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gagagagcttggttaacttgGgagaaagtttcatctgtgga	11	12	14	4	0	2	2	1	0	1	2	2	6	2	3	0	3	2	3	0	3	2	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr13:48881512G>A	uc001vcb.2	+	2	400	c.234G>A	c.(232-234)TGG>TGA	p.W78*	RB1_uc010acs.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	78					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(13)|p.?(3)|p.W78*(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGTTAACTTGGGAGAAAGTTT	0.284		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			50	15					0	0	0	0	A	48881512	A	A	48881512	4	1	163	1	0	0	0	0	0	1	0	0	13163	1241	43	4	240	4	RB1	13	48881512	Nonsense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	18982748	48881512	66288366	259	29764											
CAB39L	81617	broad.mit.edu	37	chr13	49957001	49957001	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcaggattttcacaatttCtgctggatttttgtgtgatt	7	21	8	5	0	3	1	2	1	1	0	3	3	3	3	0	2	1	1	0	2	1	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr13:49957001C>A	uc001vcw.2	-	2	544	c.46G>T	c.(46-48)GAA>TAA	p.E16*	CAB39L_uc001vcx.2_Nonsense_Mutation_p.E16*|CAB39L_uc010adf.2_Nonsense_Mutation_p.E13*	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	16					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		TTCACAATTTCTGCTGGATTT	0.308													60	21					6.20203e-27	2.26e-26	1	0	A	49957001	A	A	49957001	4	1	163	1	0	0	0	0	0	1	0	0	2538	922	32	2	999	2	CAB39L	13	49957001	Nonsense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1075489	49957001	65212877	260	29765											
ATP7B	540	broad.mit.edu	37	chr13	52542619	52542619	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggagcctgcgtagtcctcCatgactgctgcctcaaaacc	8	9	9	15	2	1	1	1	1	0	0	4	2	3	2	5	1	5	2	5	1	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr13:52542619C>T	uc001vfw.2	-	4	1825	c.1668G>A	c.(1666-1668)ATG>ATA	p.M556I	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Missense_Mutation_p.M556I|ATP7B_uc001vfy.2_Missense_Mutation_p.M445I|ATP7B_uc010tgt.1_Missense_Mutation_p.M556I|ATP7B_uc010tgu.1_Missense_Mutation_p.M556I|ATP7B_uc010tgv.1_Missense_Mutation_p.M556I|ATP7B_uc010tgw.1_Intron	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	556	Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CGTAGTCCTCCATGACTGCTG	0.522									Wilson_disease				29	6					0	0	0	0	T	52542619	T	T	52542619	3	4	163	1	0	0	0	0	1	0	0	0	1193	594	21	4	2801	4	ATP7B	13	52542619	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2585618	52542619	62627259	261	29766											
KLHL1	57626	broad.mit.edu	37	chr13	70281880	70281880	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accccaacagcatctctgggCatactcaaaggagccaccat	13	6	7	15	0	2	0	1	0	1	0	3	1	2	1	4	2	4	2	4	2	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr13:70281880C>A	uc001vip.2	-	10	2858	c.2064G>T	c.(2062-2064)ATG>ATT	p.M688I	KLHL1_uc010thm.1_Missense_Mutation_p.M627I	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	688	Kelch 5.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CATCTCTGGGCATACTCAAAG	0.408													29	6					3.57733e-08	1.02947e-07	1	0	A	70281880	A	A	70281880	3	1	163	1	0	0	0	0	1	0	0	0	8404	710	25	4	190	4	KLHL1	13	70281880	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	17739261	70281880	44887998	262	29767											
DOCK9	23348	broad.mit.edu	37	chr13	99540717	99540717	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgttttggtatgcagggcAcaaattcctccacttcaaac	10	13	8	10	0	1	0	1	0	0	0	3	0	3	0	2	2	2	4	2	2	3	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr13:99540717A>T	uc001vnt.2	-	17	1932	c.1877T>A	c.(1876-1878)GTG>GAG	p.V626E	DOCK9_uc001vnw.2_Missense_Mutation_p.V625E|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.V626E|DOCK9_uc010tis.1_Missense_Mutation_p.V625E|DOCK9_uc010tit.1_Missense_Mutation_p.V626E|DOCK9_uc010afu.1_Missense_Mutation_p.V441E	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	626					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TATGCAGGGCACAAATTCCTC	0.383													107	37					0	0	0	0	T	99540717	T	T	99540717	3	4	163	1	0	0	0	0	1	0	0	0	4716	159	6	5	4553	5	DOCK9	13	99540717	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	29258837	99540717	15629161	263	29768											
NALCN	259232	broad.mit.edu	37	chr13	102047697	102047697	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctgatgatggcacagatgCgcagcaaagagtgaacccac	13	5	12	11	2	0	5	0	3	0	2	0	5	0	5	1	1	3	4	1	1	2	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr13:102047697C>A	uc001vox.1	-	3	317	c.128G>T	c.(127-129)CGC>CTC	p.R43L	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.R43L|NALCN_uc001vpa.2_Missense_Mutation_p.R43L	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	43	Helical; Name=S1 of repeat I; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGCACAGATGCGCAGCAAAGA	0.433													39	11					2.35958e-20	8.12056e-20	1	0	A	102047697	A	A	102047697	3	1	163	1	0	0	0	0	1	0	0	0	10201	768	27	3	5256	3	NALCN	13	102047697	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2506980	102047697	13122181	264	29769											
OR4K5	79317	broad.mit.edu	37	chr14	20389063	20389063	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcagtggctgcatagccCaaattttctttattcacctt	8	17	5	11	0	3	0	2	0	1	0	3	0	3	0	2	1	2	2	2	1	3	8			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:20389063C>T	uc010tkw.1	+	1	298	c.298C>T	c.(298-300)CAA>TAA	p.Q100*		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	100	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGCATAGCCCAAATTTTCTT	0.413													76	44					0	0	0	0	T	20389063	T	T	20389063	4	4	163	1	0	0	0	0	0	1	0	0	11127	595	21	4	300	4	OR4K5	14	20389063	Nonsense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08		20389063	86960477	265	29770											
LTB4R	1241	broad.mit.edu	37	chr14	24785367	24785367	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatgagcctgtgcttcccGcggtaccccagcgaagggca	9	6	12	14	3	0	1	0	1	0	0	1	2	1	1	4	2	5	3	4	2	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:24785367G>T	uc001wos.2	+	2	831	c.510G>T	c.(508-510)CCG>CCT	p.P170P	LTB4R_uc010alp.2_Silent_p.P170P|LTB4R_uc001wou.2_Silent_p.P170P	NM_001143919	NP_001137391	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	170	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding				0				GBM - Glioblastoma multiforme(265;0.018)		TGTGCTTCCCGCGGTACCCCA	0.622													39	25					4.0492e-12	1.27772e-11	1	0	T	24785367	T	T	24785367	2	4	163	1	0	0	0	0	0	0	0	1	9121	1074	38	3		3	LTB4R	14	24785367	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	4396304	24785367	82564173	266	29771											
PRKD1	5587	broad.mit.edu	37	chr14	30046533	30046533	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctagcacttggattgatcaGgtgtgtggggtactgcagcc	7	11	15	8	0	1	1	1	1	0	0	1	2	1	2	1	4	4	4	1	4	2	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:30046533G>T	uc001wqh.2	-	18	2831	c.2650C>A	c.(2650-2652)CTG>ATG	p.L884M		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	884					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GGATTGATCAGGTGTGTGGGG	0.537													48	19					7.05377e-20	2.41345e-19	1	0	T	30046533	T	T	30046533	3	4	163	1	0	0	0	0	1	0	0	0	12580	991	35	4	92	4	PRKD1	14	30046533	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	5261166	30046533	77303007	267	29772											
RALGAPA1	253959	broad.mit.edu	37	chr14	36217955	36217955	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	attggaatgagactgttcggGttctgtagttctgtctgttt	6	18	12	5	1	3	1	0	1	3	1	4	3	3	2	0	2	0	5	0	2	2	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:36217955G>T	uc001wti.2	-	10	1478	c.1087C>A	c.(1087-1089)CCC>ACC	p.P363T	RALGAPA1_uc001wtj.2_Missense_Mutation_p.P363T|RALGAPA1_uc010tpv.1_Missense_Mutation_p.P363T|RALGAPA1_uc010tpw.1_Missense_Mutation_p.P363T|RALGAPA1_uc001wtk.1_Missense_Mutation_p.P214T	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	363					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						GACTGTTCGGGTTCTGTAGTT	0.363													13	13					2.23348e-06	6.11351e-06	1	0	T	36217955	T	T	36217955	3	4	163	1	0	0	0	0	1	0	0	0	13078	1261	44	4	5300	4	RALGAPA1	14	36217955	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	6171422	36217955	71131585	268	29773											
MDGA2	161357	broad.mit.edu	37	chr14	47342647	47342647	+	Frame_Shift_Del	DEL	C	-	-																															ctatctcacctatatgttgtCcatacatgtgataaaagaag																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:47342647delC	uc001wwj.3	-	14	2730	c.2534delG	c.(2533-2535)GGAfs	p.G845fs	MDGA2_uc001wwh.3_Frame_Shift_Del_p.G47fs|MDGA2_uc001wwi.3_Frame_Shift_Del_p.G616fs|MDGA2_uc010ani.2_Frame_Shift_Del_p.G405fs	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	845	MAM.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TATATGTTGTCCATACATGTG	0.343													---	---	---								-	47342647	-	-	47342647	7	5	163	1	0	1	0	1	0	0	0	0	9460	855	30	0	352	0	MDGA2	14	47342647	Frame_Shift_Del	DEL	C	TCGA-CR-7398-01A-11D-2012-08	11124692	47342647	60006893	269	29774											
ERO1L	30001	broad.mit.edu	37	chr14	53130549	53130549	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccaaaggatttaaaggtcTtttaattgtctgtggcctag	11	14	10	6	0	2	0	0	0	2	0	2	1	2	1	2	3	1	0	2	3	5	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:53130549T>C	uc001wzv.2	-	8	872	c.646A>G	c.(646-648)AGA>GGA	p.R216G	ERO1L_uc001wzw.2_RNA|ERO1L_uc010aof.2_RNA	NM_014584	NP_055399	Q96HE7	ERO1A_HUMAN	ERO1-like precursor	216					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor				0	Breast(41;0.226)					TTTAAAGGTCTTTTAATTGTC	0.318													2	14					0	0	0	0	C	53130549	C	C	53130549	3	2	163	1	0	0	0	0	1	0	0	0	5263	1617	56	5	796	5	ERO1L	14	53130549	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	5787902	53130549	54218991	270	29775											
GPHN	10243	broad.mit.edu	37	chr14	67389587	67389587	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaggaagaagagaagaaaGacagtggtgttgcttcaaca	18	6	13	4	0	1	5	1	0	0	5	1	7	1	6	0	2	2	2	0	2	6	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:67389587G>C	uc001xiy.2	+	7	1782	c.661G>C	c.(661-663)GAC>CAC	p.D221H	GPHN_uc001xiw.2_Missense_Mutation_p.D203H|GPHN_uc001xix.2_Missense_Mutation_p.D221H|GPHN_uc010tss.1_Missense_Mutation_p.D234H|GPHN_uc010tst.1_Missense_Mutation_p.D190H|GPHN_uc010tsu.1_Missense_Mutation_p.D111H	NM_001024218	NP_001019389	Q9NQX3	GEPH_HUMAN	gephyrin isoform 2	221	Interaction with GABARAP (By similarity).				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cell junction|cytoplasm|cytoskeleton|postsynaptic membrane	ATP binding|metal ion binding|nucleotidyltransferase activity			ovary(2)	2		all_cancers(7;0.0476)|all_hematologic(31;0.0116)		Epithelial(1;1.73e-08)|all cancers(60;3.15e-07)|OV - Ovarian serous cystadenocarcinoma(108;0.000275)|BRCA - Breast invasive adenocarcinoma(234;0.00323)|Colorectal(3;0.0938)|KIRC - Kidney renal clear cell carcinoma(182;0.184)		AGAGAAGAAAGACAGTGGTGT	0.483			T	MLL	AL								38	28					0	0	0	0	C	67389587	C	C	67389587	3	2	163	1	0	0	0	0	1	0	0	0	6648	942	33	2	687	2	GPHN	14	67389587	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	14259038	67389587	39959953	271	29776											
SIPA1L1	26037	broad.mit.edu	37	chr14	72054795	72054795	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcaccatataacctcaacccCcggagtcccaaaaatggggg	13	6	8	14	1	2	0	2	0	0	0	3	1	3	1	5	3	2	0	5	3	5	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:72054795C>T	uc001xms.2	+	2	554	c.206C>T	c.(205-207)CCC>CTC	p.P69L	SIPA1L1_uc001xmt.2_Missense_Mutation_p.P69L|SIPA1L1_uc001xmu.2_Missense_Mutation_p.P69L|SIPA1L1_uc001xmv.2_Missense_Mutation_p.P69L	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	69					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACCTCAACCCCCGGAGTCCCA	0.507													48	20					0	0	0	0	T	72054795	T	T	72054795	3	4	163	1	0	0	0	0	1	0	0	0	14394	623	22	4	208	4	SIPA1L1	14	72054795	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	4665208	72054795	35294745	272	29777											
ACOT4	122970	broad.mit.edu	37	chr14	74060510	74060510	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggctttgccacgttggctCtagcttattataactttgaa	9	16	8	8	1	1	1	0	1	1	0	1	1	1	1	1	2	3	4	1	2	5	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:74060510C>T	uc001xoo.2	+	2	816	c.562C>T	c.(562-564)CTA>TTA	p.L188L		NM_152331	NP_689544	Q8N9L9	ACOT4_HUMAN	acyl-CoA thioesterase 4	188				ALAY -> DLQS (in Ref. 1; BAC04313).	acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)		CACGTTGGCTCTAGCTTATTA	0.493													49	16					0	0	0	0	T	74060510	T	T	74060510	2	4	163	1	0	0	0	0	0	0	0	1	153	912	32	2		2	ACOT4	14	74060510	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2005715	74060510	33289030	273	29778											
SERPINA9	327657	broad.mit.edu	37	chr14	94933495	94933495	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagtgttctggctgacaaggCctgttccagttgcctcatct	6	13	10	12	0	3	1	1	1	2	0	4	1	4	1	3	2	1	4	3	2	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:94933495C>A	uc001ydf.2	-	3	1068	c.907G>T	c.(907-909)GCC>TCC	p.A303S	SERPINA9_uc001yde.2_Missense_Mutation_p.A203S|SERPINA9_uc010avc.2_Missense_Mutation_p.A154S|SERPINA9_uc001ydg.2_Missense_Mutation_p.A267S|SERPINA9_uc001ydh.1_Missense_Mutation_p.A303S|SERPINA9_uc001ydi.1_Missense_Mutation_p.A267S	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	285					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GCTGACAAGGCCTGTTCCAGT	0.537													19	20					8.00594e-06	2.1662e-05	1	0	A	94933495	A	A	94933495	3	1	163	1	0	0	0	0	1	0	0	0	14160	739	26	4	412	4	SERPINA9	14	94933495	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	20872985	94933495	12416045	274	29779											
HHIPL1	84439	broad.mit.edu	37	chr14	100119179	100119179	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcagagtctccgaggatgacGagaacgccgtggaccacagc	11	5	13	12	4	2	3	1	1	1	2	3	7	2	5	3	2	2	0	3	2	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr14:100119179G>A	uc010avs.2	+	2	939	c.874G>A	c.(874-876)GAG>AAG	p.E292K	HHIPL1_uc001ygl.1_Missense_Mutation_p.E292K	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	292					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				CGAGGATGACGAGAACGCCGT	0.607													12	9					0	0	0	0	A	100119179	A	A	100119179	3	1	163	1	0	0	0	0	1	0	0	0	7132	1059	37	1	880	1	HHIPL1	14	100119179	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	5185684	100119179	7230361	275	29780											
OR4M2	390538	broad.mit.edu	37	chr15	22368621	22368621	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgacagaatttgttctcactGgcctatcccagactccagag	10	11	8	12	0	1	4	1	1	1	3	4	4	3	4	3	1	0	1	3	1	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:22368621G>T	uc010tzu.1	+	1	46	c.46G>T	c.(46-48)GGC>TGC	p.G16C	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGTTCTCACTGGCCTATCCCA	0.333													44	135					1.41504e-22	4.95683e-22	1	0	T	22368621	T	T	22368621	3	4	163	1	0	0	0	0	1	0	0	0	11130	1348	47	4	48	4	OR4M2	15	22368621	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08		22368621	80162771	276	29781											
NDN	4692	broad.mit.edu	37	chr15	23931741	23931741	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcagcacgttccagacggcGctctctctggcgccgcggcc	4	6	13	18	7	2	1	0	0	2	1	4	1	3	1	3	3	1	4	3	3	0	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:23931741G>C	uc001ywk.2	-	1	710	c.624C>G	c.(622-624)AGC>AGG	p.S208R		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	208	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		TCCAGACGGCGCTCTCTCTGG	0.637									Prader-Willi_syndrome				19	27					0	0	0	0	C	23931741	C	C	23931741	3	2	163	1	0	0	0	0	1	0	0	0	10301	1078	38	3	345	3	NDN	15	23931741	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1563120	23931741	78599651	277	29782											
MTMR15	22909	broad.mit.edu	37	chr15	31214472	31214473	+	Frame_Shift_Del	DEL	AG	-	-																															acttgaaagccttttgtctcAgagaatttattgtcctgaca																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:31214472_31214473delAG	uc001zff.2	+	8	2378_2379	c.2087_2088delAG	c.(2086-2088)CAGfs	p.Q696fs	MTMR15_uc001zfe.2_Frame_Shift_Del_p.Q301fs	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	696	Potential.				double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		CTTTTGTCTCAGAGAATTTATT	0.426								Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---								-	31214473	-	-	31214472	7	5	163	1	0	1	0	1	0	0	0	0	9996	188	7	0	2138	0	MTMR15	15	31214472	Frame_Shift_Del	DEL	AG	TCGA-CR-7398-01A-11D-2012-08	7282731	31214472	71316920	278	29783											
BUB1B	701	broad.mit.edu	37	chr15	40494809	40494809	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctcctgcagatcccccaCgagttttagctcaacgaaga	10	9	8	14	2	1	2	1	0	0	2	4	4	4	2	4	0	3	3	4	0	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:40494809C>T	uc001zkx.3	+	14	1860	c.1648C>T	c.(1648-1650)CGA>TGA	p.R550*	BUB1B_uc010ucl.1_Nonsense_Mutation_p.R418*	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	550					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		AGATCCCCCACGAGTTTTAGC	0.398			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				56	89					0	0	0	0	T	40494809	T	T	40494809	4	4	163	1	0	0	0	0	0	1	0	0	1576	528	19	1	1702	1	BUB1B	15	40494809	Nonsense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	9280337	40494809	62036583	279	29784											
C15orf23	90417	broad.mit.edu	37	chr15	40675055	40675055	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtatggcggctcccgaagccCcgcccctggacagagttttc	6	8	12	15	3	0	1	0	0	0	1	2	3	1	2	5	3	1	3	5	3	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:40675055C>A	uc001zll.2	+	1	134	c.19C>A	c.(19-21)CCG>ACG	p.P7T	C15orf23_uc010ucp.1_Missense_Mutation_p.P7T|C15orf23_uc001zlo.2_Missense_Mutation_p.P7T|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	7						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		TCCCGAAGCCCCGCCCCTGGA	0.592													10	13					2.17888e-05	5.85511e-05	1	0	A	40675055	A	A	40675055	3	1	163	1	0	0	0	0	1	0	0	0	1791	623	22	4	21	4	C15orf23	15	40675055	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	180246	40675055	61856337	280	29785											
SPTBN5	51332	broad.mit.edu	37	chr15	42159161	42159161	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gggggtgccctctgacctggGttgcggcctgggtgaagctg	3	9	19	10	1	1	2	0	2	1	0	1	2	1	2	3	5	3	2	3	5	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:42159161G>A	uc001zos.2	-	36	6704	c.6371C>T	c.(6370-6372)ACC>ATC	p.T2124I	hsa-mir-4310|MI0015840_5'Flank	NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2159	Spectrin 18.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TCTGACCTGGGTTGCGGCCTG	0.647													6	4					0	0	0	0	A	42159161	A	A	42159161	3	1	163	1	0	0	0	0	1	0	0	0	15188	1261	44	4	4680	4	SPTBN5	15	42159161	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1484106	42159161	60372231	281	29786											
DUOX2	50506	broad.mit.edu	37	chr15	45402630	45402630	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaacccctccctcacctcaTgtagacaccagggggcacca	10	5	7	19	0	2	1	2	0	0	1	3	1	3	1	7	2	1	2	7	2	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:45402630T>A	uc010bea.2	-	9	1239	c.1036A>T	c.(1036-1038)ATG>TTG	p.M346L	DUOX2_uc001zun.2_Missense_Mutation_p.M346L	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	346	Extracellular (Potential).|Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CCTCACCTCATGTAGACACCA	0.577													21	21					0	0	0	0	A	45402630	A	A	45402630	3	1	163	1	0	0	0	0	1	0	0	0	4823	1464	51	5	3714	5	DUOX2	15	45402630	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	3243469	45402630	57128762	282	29787											
COPS2	9318	broad.mit.edu	37	chr15	49420932	49420946	+	In_Frame_Del	DEL	ACATCAGCTACATCT	-	-																															actgcaccagcaagctctccAcatcagctacatctatgttt																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:49420932_49420946delACATCAGCTACATCT	uc001zxf.2	-	12	1219_1233	c.1140_1154delAGATGTAGCTGATGT	c.(1138-1155)ATAGATGTAGCTGATGTG>ATG	p.380_385IDVADV>M	COPS2_uc001zxh.2_In_Frame_Del_p.387_392IDVADV>M|COPS2_uc010ufa.1_In_Frame_Del_p.316_321IDVADV>M	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	380_385	PCI.				cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		CAAGCTCTCCACATCAGCTACATCTATGTTTAACT	0.284													---	---	---								-	49420946	-	-	49420932	7	5	163	1	0	1	0	1	0	0	0	0	3748	159	6	0	185	0	COPS2	15	49420932	In_Frame_Del	DEL	ACATCAGCTACATCT	TCGA-CR-7398-01A-11D-2012-08	4018302	49420932	53110460	283	29788											
UNC13C	440279	broad.mit.edu	37	chr15	54586184	54586184	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaagcaacatttcaaaaagGagtcagatgattttctggga	15	11	9	6	0	4	2	3	1	1	1	4	4	4	4	0	2	2	1	0	2	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:54586184G>T	uc002ack.2	+	9	3910	c.3910G>T	c.(3910-3912)GAG>TAG	p.E1304*	UNC13C_uc002acl.2_Nonsense_Mutation_p.E134*	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1304	C2 1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TTTCAAAAAGGAGTCAGATGA	0.358													61	83					4.09106e-26	1.48617e-25	1	0	T	54586184	T	T	54586184	4	4	163	1	0	0	0	0	0	1	0	0	17054	1175	41	2	3944	2	UNC13C	15	54586184	Nonsense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	5165252	54586184	47945208	284	29789											
NEDD4	4734	broad.mit.edu	37	chr15	56130375	56130375	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttttcagctcatgttgatGtgtctaaaattaaacacaat	14	16	5	6	0	3	1	2	1	1	0	3	1	3	1	0	0	2	2	0	0	5	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:56130375G>C	uc002adj.2	-	19	3688	c.3388C>G	c.(3388-3390)CAT>GAT	p.H1130D	NEDD4_uc002adl.2_Missense_Mutation_p.H711D|NEDD4_uc002adi.2_Missense_Mutation_p.H1058D|NEDD4_uc010ugj.1_Missense_Mutation_p.H1114D|NEDD4_uc010bfm.2_Missense_Mutation_p.H1113D|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1130	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		TCATGTTGATGTGTCTAAAAT	0.244													2	9					0	0	0	0	C	56130375	C	C	56130375	3	2	163	1	0	0	0	0	1	0	0	0	10364	1377	48	4	599	4	NEDD4	15	56130375	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1544191	56130375	46401017	285	29790											
KIAA1024	23251	broad.mit.edu	37	chr15	79750339	79750339	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatccctgtcgggtgtccGtgatgaaatctcccaggtct	7	11	12	11	2	2	2	0	2	2	0	6	3	4	3	3	3	0	0	3	3	2	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:79750339G>T	uc002bew.1	+	2	1925	c.1850G>T	c.(1849-1851)CGT>CTT	p.R617L	KIAA1024_uc010unk.1_Missense_Mutation_p.R617L	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	617						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						TCGGGTGTCCGTGATGAAATC	0.488													32	54					8.88839e-20	3.03236e-19	1	0	T	79750339	T	T	79750339	3	4	163	1	0	0	0	0	1	0	0	0	8244	1145	40	3	1852	3	KIAA1024	15	79750339	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	23619964	79750339	22781053	286	29791											
AKAP13	11214	broad.mit.edu	37	chr15	86123011	86123011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacagcagaaacggaaacttCacgaagtcgtgaggagagtg	16	5	13	7	3	1	3	1	1	0	2	2	6	1	4	0	2	4	1	0	2	4	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:86123011C>T	uc002blv.1	+	7	1882	c.1712C>T	c.(1711-1713)TCA>TTA	p.S571L	AKAP13_uc002blt.1_Missense_Mutation_p.S571L|AKAP13_uc002blu.1_Missense_Mutation_p.S571L	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	571					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						ACGGAAACTTCACGAAGTCGT	0.443													50	70					0	0	0	0	T	86123011	T	T	86123011	3	4	163	1	0	0	0	0	1	0	0	0	449	838	29	2	1734	2	AKAP13	15	86123011	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	6372672	86123011	16408381	287	29792											
AGBL1	123624	broad.mit.edu	37	chr15	87066040	87066040	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttattatttgttcctgtaGccacagatgctcactgagcg	8	14	9	10	1	1	2	1	1	0	1	2	2	2	2	2	0	3	4	2	0	3	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr15:87066040G>T	uc002blz.1	+	18	2498	c.2418_splice	c.e18-1	p.N806_splice		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1						C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TGTTCCTGTAGCCACAGATGC	0.388													40	32					1.60099e-16	5.35329e-16	1	0	T	87066040	T	T	87066040	5	4	163	1	0	0	0	0	0	0	1	0	375	985	34	4	2483	4	AGBL1	15	87066040	Splice_Site	SNP	G	TCGA-CR-7398-01A-11D-2012-08	943029	87066040	15465352	288	29793											
GRIN2A	2903	broad.mit.edu	37	chr16	9857768	9857768	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggcagcttctgcagtgcgtGgagttctgccggtatcgctc	5	11	14	11	3	2	0	0	0	2	0	4	1	2	1	1	3	4	6	1	3	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:9857768G>A	uc002czo.3	-	13	4181	c.3633C>T	c.(3631-3633)TCC>TCT	p.S1211S	GRIN2A_uc010uym.1_Silent_p.S1211S|GRIN2A_uc010uyn.1_Silent_p.S1054S|GRIN2A_uc002czr.3_Silent_p.S1211S	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1211	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGCAGTGCGTGGAGTTCTGCC	0.552													194	158					0	0	0	0	A	9857768	A	A	9857768	2	1	163	1	0	0	0	0	0	0	0	1	6818	1335	47	4		4	GRIN2A	16	9857768	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08		9857768	80496985	289	29794											
PDILT	204474	broad.mit.edu	37	chr16	20386177	20386177	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacgctgtcaagggtgacGtggaaacgcccaatgacatt	12	7	13	9	3	1	2	1	2	0	0	1	4	1	4	1	3	1	1	1	3	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:20386177G>C	uc002dhc.1	-	5	871	c.648C>G	c.(646-648)CAC>CAG	p.H216Q		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	216					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						CAAGGGTGACGTGGAAACGCC	0.398													56	41					0	0	0	0	C	20386177	C	C	20386177	3	2	163	1	0	0	0	0	1	0	0	0	11728	1136	40	3	1138	3	PDILT	16	20386177	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	10528409	20386177	69968576	290	29795											
IGSF6	10261	broad.mit.edu	37	chr16	21654459	21654459	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagcaatttcctgaaaaataCgccgagcactcttcttctat	12	12	6	11	2	3	1	0	1	3	0	4	3	4	1	2	0	3	2	2	0	5	5	rs146422757		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:21654459C>A	uc002djg.1	-	5	655	c.602G>T	c.(601-603)CGT>CTT	p.R201L	uc002diq.3_Intron|METTL9_uc002dje.2_Intron|METTL9_uc002djf.2_Intron	NM_005849	NP_005840	O95976	IGSF6_HUMAN	immunoglobulin superfamily, member 6 precursor	201	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0				GBM - Glioblastoma multiforme(48;0.066)		CTGAAAAATACGCCGAGCACT	0.328													64	55					2.37532e-16	7.91998e-16	1	0	A	21654459	A	A	21654459	3	1	163	1	0	0	0	0	1	0	0	0	7642	536	19	3	131	3	IGSF6	16	21654459	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1268282	21654459	68700294	291	29796											
OTOA	146183	broad.mit.edu	37	chr16	21742247	21742247	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaattaagctctatagccaCaaaggtaatgttgtgctcca	13	12	8	8	0	1	1	0	1	1	0	2	1	2	1	2	1	3	4	2	1	6	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:21742247C>T	uc002djh.2	+	20	2298	c.2297C>T	c.(2296-2298)ACA>ATA	p.T766I	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.T687I|OTOA_uc002dji.2_Missense_Mutation_p.T442I|OTOA_uc010vbk.1_Missense_Mutation_p.T414I	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	780					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		TCTATAGCCACAAAGGTAATG	0.453													24	27					0	0	0	0	T	21742247	T	T	21742247	3	4	163	1	0	0	0	0	1	0	0	0	11356	478	17	4	2421	4	OTOA	16	21742247	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	87788	21742247	68612506	292	29797											
ERN2	10595	broad.mit.edu	37	chr16	23706706	23706706	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgcccgtccctcaaactGtcccctggaaagtgggtgat	8	9	10	14	1	1	1	1	1	0	0	3	2	3	2	4	2	2	0	4	2	2	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:23706706G>C	uc002dma.3	-	15	1928	c.1759C>G	c.(1759-1761)CAG>GAG	p.Q587E	ERN2_uc010bxp.2_Missense_Mutation_p.Q535E	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	539	Protein kinase.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CCCTCAAACTGTCCCCTGGAA	0.512													9	6					0	0	0	0	C	23706706	C	C	23706706	3	2	163	1	0	0	0	0	1	0	0	0	5262	1386	48	4	1197	4	ERN2	16	23706706	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1964459	23706706	66648047	293	29798											
AQP8	343	broad.mit.edu	37	chr16	25238439	25238439	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcccgtgcttttggacctgCggtggtggccaaccactgga	5	9	14	13	3	0	0	0	0	0	0	0	2	0	2	4	5	3	1	4	5	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:25238439C>T	uc002doc.2	+	5	735	c.653C>T	c.(652-654)GCG>GTG	p.A218V		NM_001169	NP_001160	O94778	AQP8_HUMAN	aquaporin 8	218	Extracellular (Potential).				cellular response to cAMP	integral to plasma membrane	water channel activity			upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(48;0.044)		TTTGGACCTGCGGTGGTGGCC	0.607													32	84					0	0	0	0	T	25238439	T	T	25238439	3	4	163	1	0	0	0	0	1	0	0	0	832	768	27	1	671	1	AQP8	16	25238439	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1531733	25238439	65116314	294	29799											
ZNF764	92595	broad.mit.edu	37	chr16	30566697	30566697	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctggccaaagcggcggcCgcactgcgggcaggggtagg	6	5	18	12	4	1	0	0	0	1	0	1	0	1	0	2	7	2	3	2	7	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:30566697C>T	uc002dyq.2	-	3	1126	c.1045G>A	c.(1045-1047)GGC>AGC	p.G349S	ZNF764_uc002dyr.1_Missense_Mutation_p.G348S	NM_033410	NP_219363	Q96H86	ZN764_HUMAN	zinc finger protein 764	349	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAGCGGCGGCCGCACTGCGGG	0.736													7	13					0	0	0	0	T	30566697	T	T	30566697	3	4	163	1	0	0	0	0	1	0	0	0	18205	652	23	1	185	1	ZNF764	16	30566697	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	5328258	30566697	59788056	295	29800											
SRCAP	10847	broad.mit.edu	37	chr16	30749357	30749357	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catctgatgagccacttcagGagccactggaggctgacagg	10	7	13	11	0	2	3	1	3	1	0	2	5	2	5	2	4	2	1	2	4	0	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:30749357G>T	uc002dze.1	+	34	8381	c.7996G>T	c.(7996-7998)GAG>TAG	p.E2666*	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Nonsense_Mutation_p.E2461*	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2666	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GCCACTTCAGGAGCCACTGGA	0.592													34	70					5.91797e-21	2.06078e-20	1	0	T	30749357	T	T	30749357	4	4	163	1	0	0	0	0	0	1	0	0	15201	1175	41	2	8122	2	SRCAP	16	30749357	Nonsense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	182660	30749357	59605396	296	29801											
KARS	3735	broad.mit.edu	37	chr16	75675607	75675607	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcttctcagctttcaggCgtctcttcagctcactgttg	4	17	7	13	1	6	0	4	0	3	0	8	0	6	0	0	1	2	3	0	1	0	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:75675607C>A	uc002feq.2	-	2	125	c.77G>T	c.(76-78)CGC>CTC	p.R26L	KARS_uc002fer.2_Missense_Mutation_p.R54L|KARS_uc002fes.2_5'UTR|KARS_uc010cgz.2_5'Flank|KARS_uc010cha.1_Missense_Mutation_p.R63L	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	26				Missing: Loss of nuclear localization, but no effect on packaging into HIV-1.	interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	AGCTTTCAGGCGTCTCTTCAG	0.478													30	26					7.01153e-11	2.16036e-10	1	0	A	75675607	A	A	75675607	3	1	163	1	0	0	0	0	1	0	0	0	8019	768	27	3	1768	3	KARS	16	75675607	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	44926250	75675607	14679146	297	29802											
ATMIN	23300	broad.mit.edu	37	chr16	81069786	81069786	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccccgcgctcaacatgcAcctagtcaagagccaccgcc	10	4	8	19	3	2	1	2	0	0	1	2	1	2	1	6	0	4	2	6	0	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:81069786A>T	uc002ffz.1	+	1	329	c.311A>T	c.(310-312)CAC>CTC	p.H104L	ATMIN_uc002fga.2_5'Flank|ATMIN_uc010vnn.1_5'Flank	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	104	C2H2-type 1.				response to DNA damage stimulus	nucleus	zinc ion binding				0						CTCAACATGCACCTAGTCAAG	0.602													12	4					0	0	0	0	T	81069786	T	T	81069786	3	4	163	1	0	0	0	0	1	0	0	0	1112	159	6	5	313	5	ATMIN	16	81069786	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	5394179	81069786	9284967	298	29803											
USP10	9100	broad.mit.edu	37	chr16	84793532	84793532	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgagttcactaatatgccagTacctccaaaaccccgacaag	14	8	6	13	1	1	1	1	1	0	0	2	2	2	1	5	0	3	2	5	0	6	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr16:84793532T>G	uc002fii.2	+	7	1572	c.1430T>G	c.(1429-1431)GTA>GGA	p.V477G	USP10_uc010voe.1_Missense_Mutation_p.V481G|USP10_uc010vof.1_Missense_Mutation_p.V39G|USP10_uc002fij.2_Missense_Mutation_p.V3G	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	477					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						AATATGCCAGTACCTCCAAAA	0.328													27	18					0	0	0	0	G	84793532	G	G	84793532	3	3	163	1	0	0	0	0	1	0	0	0	17109	1638	57	5	1456	5	USP10	16	84793532	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	3723746	84793532	5561221	299	29804											
PITPNM3	83394	broad.mit.edu	37	chr17	6377866	6377866	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcccaggctgacctcagggaGctgcggccccccagccgccg	5	3	14	19	3	1	1	1	1	0	0	1	2	1	2	7	3	3	2	7	3	0	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:6377866G>T	uc002gdd.3	-	10	1295	c.1144C>A	c.(1144-1146)CTC>ATC	p.L382I	PITPNM3_uc010cln.2_Missense_Mutation_p.L346I|PITPNM3_uc010clm.2_5'Flank|PITPNM3_uc002gdc.3_5'UTR	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	382					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		ACCTCAGGGAGCTGCGGCCCC	0.667													9	3					0.000274275	0.000715791	1	0	T	6377866	T	T	6377866	3	4	163	1	0	0	0	0	1	0	0	0	12007	971	34	4	1824	4	PITPNM3	17	6377866	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08		6377866	74817344	300	29805											
TP53	7157	broad.mit.edu	37	chr17	7574017	7574017	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctctcggaacatctcgaagCgctcacgcccacggatctgc	8	7	10	16	5	4	0	1	0	3	0	6	3	4	2	1	2	3	2	1	2	2	0	rs121912664		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:7574017C>A	uc002gim.2	-	10	1204	c.1010G>T	c.(1009-1011)CGC>CTC	p.R337L	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Missense_Mutation_p.R205L|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Missense_Mutation_p.R337L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	337	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R337C(12)|p.0?(7)|p.R337L(5)|p.R337H(2)|p.?(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATCTCGAAGCGCTCACGCCC	0.453		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	11					1.9806e-07	5.59032e-07	1	0	A	7574017	A	A	7574017	3	1	163	1	0	0	0	0	1	0	0	0	16448	768	27	3	179	3	TP53	17	7574017	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1196151	7574017	73621193	301	29806											
PER1	5187	broad.mit.edu	37	chr17	8044497	8044497	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaagccttggccccgccttgGgcctcctcgcagccctctcc	3	8	10	20	2	1	0	0	0	1	0	4	1	2	0	8	2	2	1	8	2	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:8044497G>A	uc002gkd.2	-	23	4000	c.3762C>T	c.(3760-3762)GCC>GCT	p.A1254A	PER1_uc010cns.2_Silent_p.A128A|PER1_uc010vuq.1_RNA	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	1254	CRY binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						CCCCGCCTTGGGCCTCCTCGC	0.637			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					118	56					0	0	0	0	A	8044497	A	A	8044497	2	1	163	1	0	0	0	0	0	0	0	1	11783	1219	43	4		4	PER1	17	8044497	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	470480	8044497	73150713	302	29807											
PFAS	5198	broad.mit.edu	37	chr17	8168408	8168408	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccgtggccgaagccctcAccaacctggtgtttgctctg	5	10	12	14	2	2	0	1	0	1	0	2	1	2	0	5	3	3	2	5	3	2	1	rs146379979		TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:8168408A>T	uc002gkr.2	+	18	2386	c.2245A>T	c.(2245-2247)ACC>TCC	p.T749S	PFAS_uc010vuv.1_Missense_Mutation_p.T325S|PFAS_uc002gks.2_5'Flank	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	749					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CGAAGCCCTCACCAACCTGGT	0.622													16	5					0	0	0	0	T	8168408	T	T	8168408	3	4	163	1	0	0	0	0	1	0	0	0	11809	159	6	5	2311	5	PFAS	17	8168408	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	123911	8168408	73026802	303	29808											
MYH8	4626	broad.mit.edu	37	chr17	10302868	10302868	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgtctttacccgcttctGtctgcaggcgcgctctctgt	4	14	10	13	3	4	1	0	0	4	1	5	1	4	1	1	1	2	3	1	1	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:10302868G>C	uc002gmm.2	-	28	3949	c.3854C>G	c.(3853-3855)ACA>AGA	p.T1285R	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1285	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ACCCGCTTCTGTCTGCAGGCG	0.473									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				45	16					0	0	0	0	C	10302868	C	C	10302868	3	2	163	1	0	0	0	0	1	0	0	0	10094	1377	48	4	2011	4	MYH8	17	10302868	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2134460	10302868	70892342	304	29809											
MYH1	4619	broad.mit.edu	37	chr17	10395801	10395801	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcttgttgacctgggactCagcaatgtcagcccgttcct	7	11	10	13	1	2	1	2	1	0	0	3	2	3	2	3	1	3	4	3	1	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:10395801C>T	uc002gmo.2	-	40	5846	c.5752G>A	c.(5752-5754)GAG>AAG	p.E1918K	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1918	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						ACCTGGGACTCAGCAATGTCA	0.488													62	31					0	0	0	0	T	10395801	T	T	10395801	3	4	163	1	0	0	0	0	1	0	0	0	10082	835	29	2	71	2	MYH1	17	10395801	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	92933	10395801	70799409	305	29810											
UNC45B	146862	broad.mit.edu	37	chr17	33486400	33486400	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctctttttcttcagacaccaAgaaggacctgaagcagatca	13	10	7	11	0	4	4	2	1	2	3	4	5	4	5	2	1	1	1	2	1	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:33486400A>G	uc002hja.2	+	8	912	c.815A>G	c.(814-816)AAG>AGG	p.K272R	UNC45B_uc002hjb.2_Missense_Mutation_p.K272R|UNC45B_uc002hjc.2_Missense_Mutation_p.K272R|UNC45B_uc010cto.2_Missense_Mutation_p.K272R	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	272					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				TCAGACACCAAGAAGGACCTG	0.507													130	233					0	0	0	0	G	33486400	G	G	33486400	3	3	163	1	0	0	0	0	1	0	0	0	17057	72	3	5	841	5	UNC45B	17	33486400	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	23090599	33486400	47708810	306	29811											
ATXN7L3	56970	broad.mit.edu	37	chr17	42274669	42274669	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggggagcaaagcgggaggCggcaatgctgcgactgcaat	11	5	17	8	3	0	0	0	0	0	0	0	3	0	2	0	5	5	4	0	5	3	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:42274669C>A	uc002iga.2	-	3	374	c.283G>T	c.(283-285)GCC>TCC	p.A95S	ATXN7L3_uc010wiv.1_5'Flank|ATXN7L3_uc002ifz.2_Missense_Mutation_p.A95S	NM_001098833	NP_001092303	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3 isoform b	95	SGF11-type.				histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		AAGCGGGAGGCGGCAATGCTG	0.592													74	84					2.23852e-25	8.03276e-25	1	0	A	42274669	A	A	42274669	3	1	163	1	0	0	0	0	1	0	0	0	1220	768	27	3	821	3	ATXN7L3	17	42274669	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	8788269	42274669	38920541	307	29812											
MYST2	11143	broad.mit.edu	37	chr17	47886541	47886541	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgtctcacaggcaagatGacaacaacaggcatgcaacc	14	6	9	12	0	1	2	1	1	1	1	2	2	1	2	1	2	5	4	1	2	4	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:47886541G>A	uc002ipm.2	+	6	850	c.724G>A	c.(724-726)GAC>AAC	p.D242N	MYST2_uc002ipl.1_Intron|MYST2_uc010wma.1_Missense_Mutation_p.D103N|MYST2_uc010wmb.1_Intron|MYST2_uc010wmc.1_Intron|MYST2_uc010wmd.1_Missense_Mutation_p.D86N|MYST2_uc010wme.1_Intron	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	242					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						CAGGCAAGATGACAACAACAG	0.473													15	41					0	0	0	0	A	47886541	A	A	47886541	3	1	163	1	0	0	0	0	1	0	0	0	10156	1290	45	2	746	2	MYST2	17	47886541	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	5611872	47886541	33308669	308	29813											
SPAG9	9043	broad.mit.edu	37	chr17	49074019	49074019	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctgacgatactgctctctCttttgttctctgcgtgaggc	5	15	9	12	2	3	2	0	2	3	0	5	3	3	2	1	1	3	2	1	1	1	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:49074019C>T	uc002itc.2	-	16	2084	c.1875G>A	c.(1873-1875)AAG>AAA	p.K625K	SPAG9_uc002itb.2_Silent_p.K611K|SPAG9_uc002itd.2_Silent_p.K615K|SPAG9_uc002itf.2_Silent_p.K446K|SPAG9_uc002ita.2_Silent_p.K468K|SPAG9_uc002ite.2_Silent_p.K455K	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	625					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			ACTGCTCTCTCTTTTGTTCTC	0.393													12	32					0	0	0	0	T	49074019	T	T	49074019	2	4	163	1	0	0	0	0	0	0	0	1	15051	912	32	2		2	SPAG9	17	49074019	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1187478	49074019	32121191	309	29814											
PRKAR1A	5573	broad.mit.edu	37	chr17	66511665	66511665	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcagttgtgcactgctcGacctgagagacccatggcat	8	10	12	11	1	0	2	0	1	0	1	1	4	0	2	2	1	3	5	2	1	0	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:66511665G>T	uc002jhg.2	+	2	305	c.125G>T	c.(124-126)CGA>CTA	p.R42L	PRKAR1A_uc002jhh.2_Missense_Mutation_p.R42L|PRKAR1A_uc002jhi.2_Missense_Mutation_p.R42L|PRKAR1A_uc002jhj.2_Missense_Mutation_p.R42L|PRKAR1A_uc002jhk.2_5'UTR|PRKAR1A_uc002jhl.2_Missense_Mutation_p.R42L|PRKAR1A_uc002jhm.2_Missense_Mutation_p.R42L	NM_212471	NP_997636	P10644	KAP0_HUMAN	cAMP-dependent protein kinase, regulatory	42	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|lung(3)|thyroid(2)|soft_tissue(2)|breast(1)	12	Breast(10;1.64e-13)					TGCACTGCTCGACCTGAGAGA	0.473			T|Mis|N|F|S	RET	papillary thyroid	myxoma|endocrine|papillary thyroid			Carney_Complex|Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial|Cardiac_Myxomas_Familial_Clustering_of				13	17					4.7546e-09	1.40255e-08	1	0	T	66511665	T	T	66511665	3	4	163	1	0	0	0	0	1	0	0	0	12565	1058	37	3	127	3	PRKAR1A	17	66511665	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	17437646	66511665	14683545	310	29815											
ABCA8	10351	broad.mit.edu	37	chr17	66914238	66914238	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtactgaagaggatcacgCggtctgttttgcgttctttc	6	14	13	8	3	3	2	1	1	2	1	4	3	3	3	0	3	2	3	0	3	2	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:66914238C>T	uc002jhp.2	-	14	2056	c.1877G>A	c.(1876-1878)CGC>CAC	p.R626H	ABCA8_uc002jhq.2_Missense_Mutation_p.R666H|ABCA8_uc010wqq.1_Missense_Mutation_p.R666H|ABCA8_uc010wqr.1_Missense_Mutation_p.R605H|ABCA8_uc002jhr.2_Missense_Mutation_p.R666H	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	626	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					GAGGATCACGCGGTCTGTTTT	0.458													22	39					0	0	0	0	T	66914238	T	T	66914238	3	4	163	1	0	0	0	0	1	0	0	0	38	768	27	1	2968	1	ABCA8	17	66914238	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	402573	66914238	14280972	311	29816											
KIF19	124602	broad.mit.edu	37	chr17	72348368	72348368	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccccagcagactacaacctGgccgtcccgcagcgcctgga	8	5	10	18	3	0	1	0	0	0	1	2	2	2	2	6	2	4	2	6	2	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:72348368G>T	uc002jkm.3	+	14	2007	c.1869G>T	c.(1867-1869)CTG>CTT	p.L623L	KIF19_uc002jkl.2_Silent_p.L581L	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	623					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						ACTACAACCTGGCCGTCCCGC	0.687													9	30					3.09899e-07	8.66391e-07	1	0	T	72348368	T	T	72348368	2	4	163	1	0	0	0	0	0	0	0	1	8321	1335	47	4		4	KIF19	17	72348368	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	5434130	72348368	8846842	312	29817											
ENPP7	339221	broad.mit.edu	37	chr17	77708950	77708950	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacaactacaaaaatgagAcggagtggagagcgaacatc	18	4	10	9	2	0	2	0	1	0	2	1	6	0	3	0	2	4	0	0	2	5	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr17:77708950A>G	uc002jxa.2	+	3	528	c.508A>G	c.(508-510)ACG>GCG	p.T170A		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	170					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CAAAAATGAGACGGAGTGGAG	0.597													21	31					0	0	0	0	G	77708950	G	G	77708950	3	3	163	1	0	0	0	0	1	0	0	0	5159	275	10	5	518	5	ENPP7	17	77708950	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	5360582	77708950	3486260	313	29818											
SMCHD1	23347	broad.mit.edu	37	chr18	2770009	2770009	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttaagaagcagcaacaaatGgcagcacttacaaaagaaaa	21	5	8	7	0	0	2	0	0	0	2	0	2	0	2	0	1	5	5	0	1	9	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr18:2770009G>C	uc002klm.3	+	39	5058	c.4869G>C	c.(4867-4869)ATG>ATC	p.M1623I	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1623					chromosome organization		ATP binding				0						AGCAACAAATGGCAGCACTTA	0.279													14	35					0	0	0	0	C	2770009	C	C	2770009	3	2	163	1	0	0	0	0	1	0	0	0	14852	1348	47	4	5023	4	SMCHD1	18	2770009	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08		2770009	75307239	314	29819											
MYOM1	8736	broad.mit.edu	37	chr18	3129467	3129467	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccctggaggcggttagtcCaccaggctcatcgctcagtg	6	8	12	15	2	2	0	2	0	0	0	4	1	3	1	4	4	0	3	4	4	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr18:3129467C>A	uc002klp.2	-	18	2891	c.2557G>T	c.(2557-2559)GGA>TGA	p.G853*	MYOM1_uc002klq.2_Intron	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	853						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GCGGTTAGTCCACCAGGCTCA	0.567											OREG0024838	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	64					8.04919e-23	2.82803e-22	1	0	A	3129467	A	A	3129467	4	1	163	1	0	0	0	0	0	1	0	0	10144	603	21	4	2584	4	MYOM1	18	3129467	Nonsense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	359458	3129467	74947781	315	29820											
EPB41L3	23136	broad.mit.edu	37	chr18	5415942	5415942	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagagcgtatggcactgagaAggaggcagacagcagaaaga	16	3	16	6	1	0	5	0	1	0	5	0	8	0	6	0	3	2	4	0	3	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr18:5415942A>T	uc002kmt.1	-	13	2028	c.1942T>A	c.(1942-1944)TTC>ATC	p.F648I	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Intron|EPB41L3_uc010wzf.1_Intron|EPB41L3_uc010wzg.1_Intron|EPB41L3_uc010dkr.2_Intron	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	648	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GGCACTGAGAAGGAGGCAGAC	0.577													29	45					0	0	0	0	T	5415942	T	T	5415942	3	4	163	1	0	0	0	0	1	0	0	0	5178	72	3	5	1361	5	EPB41L3	18	5415942	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	2286475	5415942	72661306	316	29821											
C18orf19	125228	broad.mit.edu	37	chr18	13681843	13681843	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttatggcgaaggactccTggttggggtggatgagcatc	7	11	16	7	1	0	1	0	1	0	0	2	4	1	3	1	6	2	3	1	6	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr18:13681843T>A	uc010dlh.2	-	3	666	c.234A>T	c.(232-234)CCA>CCT	p.P78P	C18orf19_uc010dlg.2_Silent_p.P78P|C18orf19_uc010dli.2_Silent_p.P78P|C18orf19_uc002ksj.3_Silent_p.P78P|C18orf19_uc010dlj.2_Intron	NM_001098801	NP_001092271	Q96ND0	CR019_HUMAN	hypothetical protein LOC125228	78						integral to membrane				breast(2)	2						GAAGGACTCCTGGTTGGGGTG	0.488													59	108					0	0	0	0	A	13681843	A	A	13681843	2	1	163	1	0	0	0	0	0	0	0	1	1905	1567	55	5		5	C18orf19	18	13681843	Silent	SNP	T	TCGA-CR-7398-01A-11D-2012-08	8265901	13681843	64395405	317	29822											
CDH2	1000	broad.mit.edu	37	chr18	25591835	25591835	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caagctcttgaggaaaaggtCccctggagttttctggcaag	10	10	12	9	0	2	1	0	1	2	0	3	3	3	3	2	4	1	3	2	4	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr18:25591835C>A	uc002kwg.2	-	4	980	c.521G>T	c.(520-522)GGA>GTA	p.G174V	CDH2_uc010xbn.1_Missense_Mutation_p.G143V	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	174	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						AGGAAAAGGTCCCCTGGAGTT	0.408													45	176					2.24722e-20	7.75653e-20	1	0	A	25591835	A	A	25591835	3	1	163	1	0	0	0	0	1	0	0	0	3120	855	30	2	2251	2	CDH2	18	25591835	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	11909992	25591835	52485413	318	29823											
MAPRE2	10982	broad.mit.edu	37	chr18	32706962	32706962	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggatccacaccttctcgaCcctcatcagccaaaagggct	11	7	7	16	1	3	0	2	0	1	0	5	2	4	1	4	2	1	1	4	2	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr18:32706962C>T	uc002kyg.2	+	5	841	c.661C>T	c.(661-663)CCC>TCC	p.P221S	MAPRE2_uc010xcb.1_Missense_Mutation_p.P178S|MAPRE2_uc010xcc.1_Missense_Mutation_p.P209S|MAPRE2_uc002kyf.2_Missense_Mutation_p.P221S|MAPRE2_uc002kyh.2_Missense_Mutation_p.P168S|MAPRE2_uc010xcd.1_Missense_Mutation_p.P178S	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	221	DCTN1-binding.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						ACCTTCTCGACCCTCATCAGC	0.418													66	33					0	0	0	0	T	32706962	T	T	32706962	3	4	163	1	0	0	0	0	1	0	0	0	9348	507	18	4	773	4	MAPRE2	18	32706962	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	7115127	32706962	45370286	319	29824											
C18orf25	147339	broad.mit.edu	37	chr18	43795987	43795987	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttcagaaagatggtgtagcGgattctacagttatttcttc	10	15	10	6	1	3	2	1	0	2	2	4	3	3	3	0	2	2	3	0	2	4	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr18:43795987G>T	uc002lbw.2	+	2	520	c.141G>T	c.(139-141)GCG>GCT	p.A47A	C18orf25_uc002lbx.2_Silent_p.A47A	NM_145055	NP_659492	Q96B23	CR025_HUMAN	ARKadia-like 1 isoform a	47										central_nervous_system(2)	2						ATGGTGTAGCGGATTCTACAG	0.458													91	25					6.71967e-41	2.61025e-40	1	0	T	43795987	T	T	43795987	2	4	163	1	0	0	0	0	0	0	0	1	1908	1103	39	3		3	C18orf25	18	43795987	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	11089025	43795987	34281261	320	29825											
ST8SIA5	29906	broad.mit.edu	37	chr18	44284609	44284609	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagttatattcaaaaggcccCtcataaaattcaaagtacct	16	11	5	9	0	3	0	3	0	0	0	3	1	3	0	3	1	1	2	3	1	8	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr18:44284609C>A	uc002lcj.1	-	2	718	c.150G>T	c.(148-150)GAG>GAT	p.E50D	ST8SIA5_uc002lci.1_Translation_Start_Site|ST8SIA5_uc010xcy.1_Missense_Mutation_p.E86D|ST8SIA5_uc010xcz.1_Intron|ST8SIA5_uc010dno.1_Missense_Mutation_p.E86D	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	50	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						CAAAAGGCCCCTCATAAAATT	0.512													7	241					0.00307968	0.0078289	1	0	A	44284609	A	A	44284609	3	1	163	1	0	0	0	0	1	0	0	0	15301	680	24	4	1004	4	ST8SIA5	18	44284609	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	488622	44284609	33792639	321	29826											
TCEB3B	51224	broad.mit.edu	37	chr18	44560256	44560256	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgagaggtcccagagctcTgagaagacatggctgggcac	10	7	14	10	0	2	4	0	2	2	4	3	6	3	4	1	3	1	3	1	3	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr18:44560256T>C	uc002lcr.1	-	1	1733	c.1380A>G	c.(1378-1380)TCA>TCG	p.S460S	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	460					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CCCAGAGCTCTGAGAAGACAT	0.592													103	72					0	0	0	0	C	44560256	C	C	44560256	2	2	163	1	0	0	0	0	0	0	0	1	15748	1567	55	5		5	TCEB3B	18	44560256	Silent	SNP	T	TCGA-CR-7398-01A-11D-2012-08	275647	44560256	33516992	322	29827											
DCC	1630	broad.mit.edu	37	chr18	50866235	50866235	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcccttacgctgagacagtgCgtgtggacagcaagcagcga	10	6	14	11	3	0	1	0	1	0	1	0	4	0	2	1	1	5	3	1	1	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr18:50866235C>A	uc002lfe.1	+	15	2904	c.2317C>A	c.(2317-2319)CGT>AGT	p.R773S	DCC_uc010xdr.1_Missense_Mutation_p.R621S|DCC_uc010dpf.1_Missense_Mutation_p.R428S	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	773	Extracellular (Potential).|Fibronectin type-III 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGAGACAGTGCGTGTGGACAG	0.418													68	49					3.13765e-25	1.1225e-24	1	0	A	50866235	A	A	50866235	3	1	163	1	0	0	0	0	1	0	0	0	4299	768	27	3	2375	3	DCC	18	50866235	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	6305979	50866235	27211013	323	29828											
LPPR3	79948	broad.mit.edu	37	chr19	813188	813188	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccacttggcgcgcaccccGgcgccgcttttgggggacag	5	6	15	15	5	0	0	0	0	0	0	0	1	0	1	4	4	1	2	4	4	0	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:813188G>A	uc002lpx.1	-	8	1603	c.1539C>T	c.(1537-1539)GCC>GCT	p.A513A	LPPR3_uc010dru.1_Silent_p.A425A|LPPR3_uc002lpw.1_Silent_p.A541A|LPPR3_uc002lpy.1_Silent_p.A294A|hsa-mir-3187|MI0014231_5'Flank	NM_024888	NP_079164	Q6T4P5	LPPR3_HUMAN	plasticity-related protein 2	513						integral to membrane	phosphatidate phosphatase activity				0						CGCGCACCCCGGCGCCGCTTT	0.637													8	9					0	0	0	0	A	813188	A	A	813188	2	1	163	1	0	0	0	0	0	0	0	1	8976	1103	39	1		1	LPPR3	19	813188	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08		813188	58315795	324	29829											
MUC16	94025	broad.mit.edu	37	chr19	9064360	9064360	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaggatgaggtgaggtcaCggcaggtaaagacagcgggg	13	4	18	6	2	1	3	1	2	0	1	1	4	1	4	0	7	2	2	0	7	3	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:9064360C>T	uc002mkp.2	-	3	23290	c.23086G>A	c.(23086-23088)GTG>ATG	p.V7696M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7698	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGAGGTCACGGCAGGTAAA	0.582													18	49					0	0	0	0	T	9064360	T	T	9064360	3	4	163	1	0	0	0	0	1	0	0	0	10026	536	19	1	20765	1	MUC16	19	9064360	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	8251172	9064360	50064623	325	29830											
DNMT1	1786	broad.mit.edu	37	chr19	10265725	10265725	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggatccatcagaatgtattcGgcaaatgctggggtgaacag	12	9	13	7	1	1	2	1	1	0	1	3	3	2	3	1	4	2	3	1	4	4	2	rs75443147	by1000genomes	TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:10265725G>A	uc002mng.2	-	19	1632	c.1452C>T	c.(1450-1452)GCC>GCT	p.A484A	DNMT1_uc010xlc.1_Silent_p.A500A|DNMT1_uc002mnh.2_Silent_p.A379A|DNMT1_uc010xld.1_Silent_p.A484A	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	484	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GAATGTATTCGGCAAATGCTG	0.532													37	38					0	0	0	0	A	10265725	A	A	10265725	2	1	163	1	0	0	0	0	0	0	0	1	4697	1103	39	1		1	DNMT1	19	10265725	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1201365	10265725	48863258	326	29831											
MAST1	22983	broad.mit.edu	37	chr19	12958435	12958435	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccccgcagccccgggcgCtccccctcctcctacgacaa	5	6	7	23	4	1	0	0	0	1	0	5	1	4	0	8	1	2	2	8	1	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:12958435C>T	uc002mvm.2	+	6	626	c.498C>T	c.(496-498)CGC>CGT	p.R166R	MAST1_uc002mvk.2_Silent_p.R162R|MAST1_uc002mvl.2_Missense_Mutation_p.A140V	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	166					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						GCCCCGGGCGCTCCCCCTCCT	0.627											OREG0025277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	43					0	0	0	0	T	12958435	T	T	12958435	2	4	163	1	0	0	0	0	0	0	0	1	9377	784	28	4		4	MAST1	19	12958435	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2692710	12958435	46170548	327	29832											
IL27RA	9466	broad.mit.edu	37	chr19	14163009	14163009	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagcccgcccaggccacCgccccgcttgactctgggta	5	6	10	20	3	1	1	0	1	1	0	2	1	2	1	7	2	1	2	7	2	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:14163009C>A	uc002mxx.2	+	14	2241	c.1818C>A	c.(1816-1818)ACC>ACA	p.T606T		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	606	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						CCCAGGCCACCGCCCCGCTTG	0.662													16	14					3.52763e-06	9.61116e-06	1	0	A	14163009	A	A	14163009	2	1	163	1	0	0	0	0	0	0	0	1	7720	639	23	3		3	IL27RA	19	14163009	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1204574	14163009	44965974	328	29833											
CIB3	117286	broad.mit.edu	37	chr19	16275696	16275696	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgtctgctccaggtcccaCgcacaaatgtagtcgtcgtt	8	10	9	14	4	1	0	0	0	1	0	5	0	3	0	3	1	1	4	3	1	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:16275696C>A	uc002nds.2	-	5	375	c.375G>T	c.(373-375)GCG>GCT	p.A125A	CIB3_uc010eae.2_Silent_p.A64A|CIB3_uc010eaf.2_RNA|CIB3_uc010eag.2_Silent_p.A76A	NM_054113	NP_473454	Q96Q77	CIB3_HUMAN	DNA-dependent protein kinase catalytic	125	EF-hand 2.|1 (Potential).						calcium ion binding			ovary(1)	1						CCAGGTCCCACGCACAAATGT	0.597													28	87					1.04121e-07	2.96733e-07	1	0	A	16275696	A	A	16275696	2	1	163	1	0	0	0	0	0	0	0	1	3437	523	19	3		3	CIB3	19	16275696	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2112687	16275696	42853287	329	29834											
GLT25D1	79709	broad.mit.edu	37	chr19	17679367	17679367	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctatccgcaagcgagaccGccggggctgctttgcagttc	6	8	12	15	4	0	1	0	0	0	1	2	2	1	1	4	2	3	5	4	2	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:17679367G>T	uc002nhc.1	+	5	686	c.674G>T	c.(673-675)CGC>CTC	p.R225L	GLT25D1_uc010eax.1_5'UTR	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	225					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0						AAGCGAGACCGCCGGGGCTGC	0.617													25	43					1.77063e-15	5.85403e-15	1	0	T	17679367	T	T	17679367	3	4	163	1	0	0	0	0	1	0	0	0	6503	1087	38	3	692	3	GLT25D1	19	17679367	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1403671	17679367	41449616	330	29835											
UNC13A	23025	broad.mit.edu	37	chr19	17766748	17766748	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcagctgcaggcaccttGtcgggcgtggctggcttggg	3	10	17	11	2	1	0	1	0	0	0	2	0	1	0	1	5	3	6	1	5	0	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:17766748G>T	uc002nhd.2	-	11	1491	c.1491C>A	c.(1489-1491)GAC>GAA	p.D497E		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	409					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						CAGGCACCTTGTCGGGCGTGG	0.697													5	16					1.23904e-05	3.34484e-05	1	0	T	17766748	T	T	17766748	3	4	163	1	0	0	0	0	1	0	0	0	17052	1368	48	4	4016	4	UNC13A	19	17766748	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	87381	17766748	41362235	331	29836											
HAPLN4	404037	broad.mit.edu	37	chr19	19368850	19368850	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggttcacgatggggtagcGcgcactgccatcggccagcc	6	6	15	14	5	1	0	1	0	0	0	2	1	1	0	3	4	3	3	3	4	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:19368850G>A	uc002nmb.2	-	5	1040	c.985C>T	c.(985-987)CGC>TGC	p.R329C	HAPLN4_uc002nmc.2_Missense_Mutation_p.R329C	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	329	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			ATGGGGTAGCGCGCACTGCCA	0.731													4	4					0	0	0	0	A	19368850	A	A	19368850	3	1	163	1	0	0	0	0	1	0	0	0	6996	1087	38	1	227	1	HAPLN4	19	19368850	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1602102	19368850	39760133	332	29837											
ZNF99	7652	broad.mit.edu	37	chr19	22941167	22941167	+	Frame_Shift_Del	DEL	C	-	-																															agaaatgcttaaaagctttgCcacattcttcacatttgcaa																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:22941167delC	uc010xrh.1	-	5	1271	c.1271delG	c.(1270-1272)GGCfs	p.G424fs		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAAAGCTTTGCCACATTCTTC	0.338													---	---	---								-	22941167	-	-	22941167	7	5	163	1	0	1	0	1	0	0	0	0	18271	739	26	0	1853	0	ZNF99	19	22941167	Frame_Shift_Del	DEL	C	TCGA-CR-7398-01A-11D-2012-08	3572317	22941167	36187816	333	29838											
SLC7A9	11136	broad.mit.edu	37	chr19	33333131	33333131	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacgatgagtcctagaatCgtcaggccataaaacagcca	15	7	8	11	2	2	2	2	1	0	1	4	3	3	2	3	1	2	0	3	1	4	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:33333131C>A	uc002ntv.3	-	11	1284	c.1167G>T	c.(1165-1167)ACG>ACT	p.T389T	SLC7A9_uc002ntt.3_RNA|SLC7A9_uc002ntu.3_Silent_p.T389T|SLC7A9_uc002ntw.3_Silent_p.T180T	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	389	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	GTCCTAGAATCGTCAGGCCAT	0.428													15	42					4.7546e-09	1.40255e-08	1	0	A	33333131	A	A	33333131	2	1	163	1	0	0	0	0	0	0	0	1	14769	871	31	3		3	SLC7A9	19	33333131	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	10391964	33333131	25795852	334	29839											
FCGBP	8857	broad.mit.edu	37	chr19	40421289	40421289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccatgaagtcgaagcgccGgccgtcgaagctcacatagt	10	6	12	13	5	1	1	1	1	0	0	3	3	1	1	3	1	2	1	3	1	4	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:40421289G>A	uc002omp.3	-	5	2640	c.2632C>T	c.(2632-2634)CGG>TGG	p.R878W		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	878	VWFD 2.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGAAGCGCCGGCCGTCGAAG	0.667													4	9					0	0	0	0	A	40421289	A	A	40421289	3	1	163	1	0	0	0	0	1	0	0	0	5810	1115	39	1	13713	1	FCGBP	19	40421289	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	7088158	40421289	18707694	335	29840											
FKRP	79147	broad.mit.edu	37	chr19	47259642	47259642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcctacctctacgaggagcGctggacgcccccctgctgcc	5	6	11	19	4	1	0	0	0	1	0	1	3	1	2	6	2	5	2	6	2	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:47259642G>A	uc002pfn.2	+	4	1232	c.935G>A	c.(934-936)CGC>CAC	p.R312H	FKRP_uc002pfp.2_Missense_Mutation_p.R312H	NM_024301	NP_077277	Q9H9S5	FKRP_HUMAN	fukutin-related protein	312			R -> C (in MDDGC5).			extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			pancreas(1)	1		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		TACGAGGAGCGCTGGACGCCC	0.726													6	4					0	0	0	0	A	47259642	A	A	47259642	3	1	163	1	0	0	0	0	1	0	0	0	5949	1087	38	1	937	1	FKRP	19	47259642	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	6838353	47259642	11869341	336	29841											
TSKS	60385	broad.mit.edu	37	chr19	50245223	50245223	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctcgtccactagtgaggtCagtgctcggtccagcagctg	7	9	12	13	2	1	1	1	1	0	0	5	1	3	1	3	2	3	3	3	2	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:50245223C>T	uc002ppm.2	-	9	1427	c.1416G>A	c.(1414-1416)CTG>CTA	p.L472L		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	472							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CTAGTGAGGTCAGTGCTCGGT	0.607													27	38					0	0	0	0	T	50245223	T	T	50245223	2	4	163	1	0	0	0	0	0	0	0	1	16693	813	29	2		2	TSKS	19	50245223	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	2985581	50245223	8883760	337	29842											
KLK8	11202	broad.mit.edu	37	chr19	51503433	51503433	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgttgtagcaggggtgtggGatggactgaaccacaggtat	9	10	16	6	0	0	1	0	1	0	0	0	3	0	3	1	5	2	4	1	5	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:51503433G>A	uc002pur.1	-	4	491	c.312C>T	c.(310-312)ATC>ATT	p.I104I	KLK8_uc002puq.1_Silent_p.I149I|KLK8_uc002pus.1_Intron|KLK8_uc002put.1_Intron|KLK8_uc002puu.1_Silent_p.I104I|KLK9_uc002puv.1_Intron	NM_007196	NP_009127	O60259	KLK8_HUMAN	kallikrein 8 isoform 1 preproprotein	104	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		AGGGGTGTGGGATGGACTGAA	0.522													54	62					0	0	0	0	A	51503433	A	A	51503433	2	1	163	1	0	0	0	0	0	0	0	1	8449	1164	41	2		2	KLK8	19	51503433	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1258210	51503433	7625550	338	29843											
KLK9	284366	broad.mit.edu	37	chr19	51507039	51507039	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccagggtatgcccagtgaCagagtttgttctccaggatg	8	11	13	9	0	1	2	0	1	1	1	3	3	2	3	3	2	1	3	3	2	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:51507039C>T	uc002pux.1	-	4	611	c.524G>A	c.(523-525)TGT>TAT	p.C175Y	KLK9_uc002puw.1_RNA|KLK9_uc010eol.1_Missense_Mutation_p.C146Y|KLK8_uc002puq.1_5'Flank|KLK8_uc002pur.1_5'Flank|KLK8_uc002pus.1_5'Flank|KLK8_uc002put.1_5'Flank|KLK8_uc002puu.1_5'Flank|KLK9_uc002puv.1_RNA	NM_012315	NP_036447	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9 precursor	175	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		TGCCCAGTGACAGAGTTTGTT	0.567													21	35					0	0	0	0	T	51507039	T	T	51507039	3	4	163	1	0	0	0	0	1	0	0	0	8450	478	17	4	236	4	KLK9	19	51507039	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	3606	51507039	7621944	339	29844											
PEG3	5178	broad.mit.edu	37	chr19	57335999	57335999	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacttcttaggtttggtggCagacaagtgctttggaggca	8	12	15	6	0	1	1	0	0	1	1	1	3	1	3	0	6	1	4	0	6	2	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:57335999C>T	uc002qnu.2	-	1	376	c.25G>A	c.(25-27)GCC>ACC	p.A9T	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.A9T|PEG3_uc002qnv.2_Missense_Mutation_p.A9T|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Missense_Mutation_p.A9T	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	9					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GGTTTGGTGGCAGACAAGTGC	0.488													18	58					0	0	0	0	T	57335999	T	T	57335999	3	4	163	1	0	0	0	0	1	0	0	0	11774	710	25	4		4	PEG3	19	57335999	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	5828960	57335999	1792984	340	29845											
ZIM3	114026	broad.mit.edu	37	chr19	57647112	57647112	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaatgctcttccacagctaTgacattcaaagggtttttga	11	13	8	9	1	2	2	1	2	1	0	3	3	3	2	1	1	2	3	1	1	3	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr19:57647112T>C	uc002qnz.1	-	5	979	c.593A>G	c.(592-594)CAT>CGT	p.H198R		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	198	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCCACAGCTATGACATTCAAA	0.438													68	69					0	0	0	0	C	57647112	C	C	57647112	3	2	163	1	0	0	0	0	1	0	0	0	17752	1464	51	5	829	5	ZIM3	19	57647112	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	311113	57647112	1481871	341	29846											
TMC2	117532	broad.mit.edu	37	chr20	2577848	2577848	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaggggagagtgacaacttCacattcagcttcaagatgtt	13	10	11	7	0	3	3	3	1	0	2	3	5	3	3	0	2	2	2	0	2	3	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr20:2577848C>T	uc002wgf.1	+	10	1143	c.1128C>T	c.(1126-1128)TTC>TTT	p.F376F	TMC2_uc002wgg.1_Silent_p.F360F|TMC2_uc010zpw.1_Silent_p.F208F|TMC2_uc010zpx.1_Silent_p.F207F	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	376	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GTGACAACTTCACATTCAGCT	0.507													18	33					0	0	0	0	T	2577848	T	T	2577848	2	4	163	1	0	0	0	0	0	0	0	1	16051	825	29	2		2	TMC2	20	2577848	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08		2577848	60447672	342	29847											
SLC4A11	83959	broad.mit.edu	37	chr20	3210334	3210334	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggaggctggcgttgaggctGgcgccgaggcctgacaggct	5	7	19	10	3	0	2	0	2	0	0	0	4	0	3	2	7	0	4	2	7	0	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr20:3210334G>A	uc002wig.2	-	13	1674	c.1626C>T	c.(1624-1626)GCC>GCT	p.A542A	SLC4A11_uc010zqe.1_Silent_p.A569A|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Silent_p.A526A	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	542	Extracellular (Potential).|Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						CGTTGAGGCTGGCGCCGAGGC	0.612													26	26					0	0	0	0	A	3210334	A	A	3210334	2	1	163	1	0	0	0	0	0	0	0	1	14716	1335	47	4		4	SLC4A11	20	3210334	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	632486	3210334	59815186	343	29848											
SLC17A9	63910	broad.mit.edu	37	chr20	61594696	61594696	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaacagagtcccctggagaCggctcttccggaagcctgct	9	7	11	14	2	1	2	0	0	1	2	3	4	3	3	4	3	3	2	4	3	2	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr20:61594696C>T	uc002yea.3	+	6	884	c.700C>T	c.(700-702)CGG>TGG	p.R234W	SLC17A9_uc002ydz.3_Missense_Mutation_p.R228W|SLC17A9_uc011aap.1_Missense_Mutation_p.R254W	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	234					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						CCCCTGGAGACGGCTCTTCCG	0.647													16	19					0	0	0	0	T	61594696	T	T	61594696	3	4	163	1	0	0	0	0	1	0	0	0	14489	527	19	1	722	1	SLC17A9	20	61594696	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	58384362	61594696	1430824	344	29849											
TPTE	7179	broad.mit.edu	37	chr21	10910382	10910382	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaattaatattttgtctgtTgtaatgttatcaagtaccta	12	19	5	5	0	3	0	2	0	1	0	3	0	3	0	1	0	1	4	1	0	8	9			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr21:10910382T>C	uc002yip.1	-	22	1742	c.1374A>G	c.(1372-1374)ACA>ACG	p.T458T	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.T440T|TPTE_uc002yir.1_Silent_p.T420T|TPTE_uc010gkv.1_Silent_p.T320T	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	458	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTTGTCTGTTGTAATGTTAT	0.338													6	107					0	0	0	0	C	10910382	C	C	10910382	2	2	163	1	0	0	0	0	0	0	0	1	16497	1799	63	5		5	TPTE	21	10910382	Silent	SNP	T	TCGA-CR-7398-01A-11D-2012-08		10910382	37219513	345	29850											
TPTE	7179	broad.mit.edu	37	chr21	10969098	10969098	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcactgataggtgacacccgGgctgctcctttaaattcact	9	12	8	12	1	2	2	2	2	0	0	3	2	3	2	2	2	1	2	2	2	3	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr21:10969098G>T	uc002yip.1	-	7	518	c.150C>A	c.(148-150)GCC>GCA	p.A50A	TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Intron|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	50					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTGACACCCGGGCTGCTCCTT	0.328													16	101					3.41278e-10	1.04334e-09	1	0	T	10969098	T	T	10969098	2	4	163	1	0	0	0	0	0	0	0	1	16497	1219	43	4		4	TPTE	21	10969098	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	58716	10969098	37160797	346	29851											
PFKL	5211	broad.mit.edu	37	chr21	45732884	45732884	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatctcagagactacagccCggacctactcgcacctgaac	12	6	8	15	2	1	3	1	1	1	2	3	5	1	4	3	1	4	1	3	1	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr21:45732884C>T	uc002zel.2	+	5	510	c.451C>T	c.(451-453)CGG>TGG	p.R151W	PFKL_uc002zek.2_Missense_Mutation_p.R198W|PFKL_uc011afd.1_Missense_Mutation_p.R198W	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	151			R -> W.		fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		GACTACAGCCCGGACCTACTC	0.647													18	37					0	0	0	0	T	45732884	T	T	45732884	3	4	163	1	0	0	0	0	1	0	0	0	11819	643	23	1	469	1	PFKL	21	45732884	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	34763786	45732884	2397011	347	29852											
KRTAP10-3	386682	broad.mit.edu	37	chr21	45978296	45978296	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggcttgcagcagacaggCacgcagcaggcctgctggca	9	5	14	13	1	0	1	0	0	0	1	0	1	0	1	1	4	4	8	1	4	0	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr21:45978296C>T	uc002zfj.1	-	1	348	c.303G>A	c.(301-303)GTG>GTA	p.V101V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198696	NP_941969	P60369	KR103_HUMAN	keratin associated protein 10-3	101	7.|18 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						agcagacaggcacgcagcagg	0.189													71	126					0	0	0	0	T	45978296	T	T	45978296	2	4	163	1	0	0	0	0	0	0	0	1	8549	697	25	4		4	KRTAP10-3	21	45978296	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	245412	45978296	2151599	348	29853											
COL18A1	80781	broad.mit.edu	37	chr21	46912603	46912603	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgtccctctttccccagggCcggccgggtttcgcaggctt	2	10	12	17	4	1	0	0	0	1	0	4	0	3	0	6	4	0	3	6	4	0	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr21:46912603C>A	uc011afs.1	+	23	3456	c.3435C>A	c.(3433-3435)GGC>GGA	p.G1145G	COL18A1_uc002zhg.2_Silent_p.G730G|COL18A1_uc002zhi.2_Silent_p.G910G	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1145	Triple-helical region 5 (COL5).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		TTCCCCAGGGCCGGCCGGGTT	0.701													25	48					7.41945e-09	2.16692e-08	1	0	A	46912603	A	A	46912603	2	1	163	1	0	0	0	0	0	0	0	1	3690	726	26	4		4	COL18A1	21	46912603	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	934307	46912603	1217292	349	29854											
PIWIL3	440822	broad.mit.edu	37	chr22	25119105	25119105	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggtggcttaccattcattCctagtcaactctacatcaat	11	13	5	12	0	4	0	3	0	1	0	5	0	5	0	2	2	3	1	2	2	5	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr22:25119105C>A	uc003abd.1	-	19	2793	c.2376G>T	c.(2374-2376)AGG>AGT	p.R792S	PIWIL3_uc011ajx.1_Missense_Mutation_p.R674S|PIWIL3_uc011ajy.1_Missense_Mutation_p.R674S|PIWIL3_uc010gut.1_Missense_Mutation_p.R783S	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	792	Piwi.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						ACCATTCATTCCTAGTCAACT	0.338													26	8					5.45727e-16	1.81446e-15	1	0	A	25119105	A	A	25119105	3	1	163	1	0	0	0	0	1	0	0	0	12014	854	30	2	284	2	PIWIL3	22	25119105	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08		25119105	26185461	350	29855											
TBC1D10A	83874	broad.mit.edu	37	chr22	30688801	30688803	+	In_Frame_Del	DEL	CGC	-	-																															ccgcagctgaatgaggtgttCgcgctcaatctggcgctctg																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr22:30688801_30688803delCGC	uc011akt.1	-	11	1112_1114	c.1088_1090delGCG	c.(1087-1092)CGCGAA>CAA	p.363_364RE>Q	GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_Intron|GATSL3_uc003ahh.2_Intron|GATSL3_uc010gvq.2_Intron|GATSL3_uc003ahi.2_In_Frame_Del_p.221_222RE>Q|TBC1D10A_uc003ahj.3_In_Frame_Del_p.275_276RE>Q|TBC1D10A_uc010gvu.2_In_Frame_Del_p.370_371RE>Q|TBC1D10A_uc003ahk.3_In_Frame_Del_p.363_364RE>Q	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	363_364						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						ATGAGGTGTTCGCGCTCAATCTG	0.635													---	---	---								-	30688803	-	-	30688801	7	5	163	1	0	1	0	1	0	0	0	0	15664	893	31	0	440	0	TBC1D10A	22	30688801	In_Frame_Del	DEL	CGC	TCGA-CR-7398-01A-11D-2012-08	5569696	30688801	20615765	351	29856											
SMCR7L	54471	broad.mit.edu	37	chr22	39910115	39910115	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aatgtcatcctccacttggcCcaggaggaggctgactggtc	8	9	12	12	0	1	1	1	1	0	0	4	3	3	3	3	5	0	1	3	5	1	1			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chr22:39910115C>T	uc003axx.2	+	6	1677	c.1179C>T	c.(1177-1179)GCC>GCT	p.A393A	SMCR7L_uc003axw.2_Silent_p.A393A|SMCR7L_uc010gxz.1_Silent_p.A215A|SMCR7L_uc003axy.2_Silent_p.A215A	NM_019008	NP_061881	Q9NQG6	SMC7L_HUMAN	hypothetical protein LOC54471	393						integral to membrane|mitochondrion				central_nervous_system(1)	1	Melanoma(58;0.04)					TCCACTTGGCCCAGGAGGAGG	0.592											OREG0026577	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	11					0	0	0	0	T	39910115	T	T	39910115	2	4	163	1	0	0	0	0	0	0	0	1	14855	610	22	4		4	SMCR7L	22	39910115	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	9221314	39910115	11394451	352	29857											
CNKSR2	22866	broad.mit.edu	37	chrX	21670529	21670529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtacctcgaccttttcttgGatatctgtcaaaataccacc	10	14	5	12	1	3	0	1	0	2	0	4	2	3	1	4	1	2	1	4	1	5	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:21670529G>A	uc004czx.1	+	22	3031	c.2995G>A	c.(2995-2997)GAT>AAT	p.D999N	CNKSR2_uc011mjo.1_Missense_Mutation_p.D969N	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	999					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						CCTTTTCTTGGATATCTGTCA	0.393													30	15					0	0	0	0	A	21670529	A	A	21670529	3	1	163	1	0	0	0	0	1	0	0	0	3622	1174	41	2	3090	2	CNKSR2	23	21670529	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08		21670529	133600031	353	29858											
KLHL34	257240	broad.mit.edu	37	chrX	21674749	21674749	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgtgaccacccgcgagtcGtcggccaggggagaggatgc	7	4	17	13	5	0	2	0	1	0	1	2	5	0	3	4	4	1	0	4	4	0	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:21674749G>A	uc004czz.1	-	1	1700	c.1158C>T	c.(1156-1158)GAC>GAT	p.D386D		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	386	Kelch 2.									ovary(1)	1						CCCGCGAGTCGTCGGCCAGGG	0.682													10	6					0	0	0	0	A	21674749	A	A	21674749	2	1	163	1	0	0	0	0	0	0	0	1	8426	1136	40	1		1	KLHL34	23	21674749	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	4220	21674749	133595811	354	29859											
DMD	1756	broad.mit.edu	37	chrX	32361265	32361265	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattacctttattttcctttCatctctgggctcaggtaggc	6	17	7	11	0	3	0	2	0	1	0	5	0	4	0	2	3	1	2	2	3	3	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:32361265C>A	uc004dda.1	-	40	5969	c.5725G>T	c.(5725-5727)GAA>TAA	p.E1909*	DMD_uc004dcw.2_Nonsense_Mutation_p.E565*|DMD_uc004dcx.2_Nonsense_Mutation_p.E568*|DMD_uc004dcz.2_Nonsense_Mutation_p.E1786*|DMD_uc004dcy.1_Nonsense_Mutation_p.E1905*|DMD_uc004ddb.1_Nonsense_Mutation_p.E1901*|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1909	Spectrin 13.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATTTTCCTTTCATCTCTGGGC	0.343													25	12					7.07758e-08	2.02192e-07	1	0	A	32361265	A	A	32361265	4	1	163	1	0	0	0	0	0	1	0	0	4602	835	29	2	5640	2	DMD	23	32361265	Nonsense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	10686516	32361265	122909295	355	29860											
FAM47C	442444	broad.mit.edu	37	chrX	37027150	37027150	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agactggagtgtcccatctcCgcccacagcctcccaagact	9	7	8	17	1	1	2	0	0	1	2	4	3	3	3	5	1	1	0	5	1	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:37027150C>A	uc004ddl.1	+	1	681	c.667C>A	c.(667-669)CGC>AGC	p.R223S		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	223										ovary(3)	3						GTCCCATCTCCGCCCACAGCC	0.657													35	23					1.36239e-07	3.86394e-07	1	0	A	37027150	A	A	37027150	3	1	163	1	0	0	0	0	1	0	0	0	5603	652	23	3	669	3	FAM47C	23	37027150	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	4665885	37027150	118243410	356	29861											
ZNF630	57232	broad.mit.edu	37	chrX	47918863	47918863	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggagaatgctcttccatacTtagtacattcatagggtttc	10	14	9	8	0	2	1	1	0	1	1	4	2	3	1	1	2	3	3	1	2	5	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:47918863T>A	uc004div.3	-	5	1220	c.968A>T	c.(967-969)AAG>ATG	p.K323M	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.K199M	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	323	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						TCTTCCATACTTAGTACATTC	0.433													26	7					0	0	0	0	A	47918863	A	A	47918863	3	1	163	1	0	0	0	0	1	0	0	0	18121	1609	56	5	1009	5	ZNF630	23	47918863	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	10891713	47918863	107351697	357	29862											
SHROOM4	57477	broad.mit.edu	37	chrX	50377848	50377848	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgttcaggggcactatggcGatgccctgtgggtcctatga	6	11	14	10	1	1	1	1	1	0	0	2	2	2	1	2	4	1	2	2	4	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:50377848G>C	uc004dpe.2	-	4	1251	c.1225C>G	c.(1225-1227)CGC>GGC	p.R409G	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.R293G	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	409					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GCACTATGGCGATGCCCTGTG	0.572													10	5					0	0	0	0	C	50377848	C	C	50377848	3	2	163	1	0	0	0	0	1	0	0	0	14361	1058	37	3	3280	3	SHROOM4	23	50377848	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2458985	50377848	104892712	358	29863											
ALAS2	212	broad.mit.edu	37	chrX	55042056	55042056	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttatgcataattccatcacGctccccaatcccagcgcccc	9	9	4	19	2	1	0	1	0	0	0	4	0	4	0	6	0	2	2	6	0	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:55042056G>A	uc004dua.3	-	8	1261	c.1123C>T	c.(1123-1125)CGT>TGT	p.R375C	ALAS2_uc004dub.3_Missense_Mutation_p.R362C|ALAS2_uc004dud.3_Missense_Mutation_p.R338C	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	375					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	ATTCCATCACGCTCCCCAATC	0.522													28	15					0	0	0	0	A	55042056	A	A	55042056	3	1	163	1	0	0	0	0	1	0	0	0	485	1087	38	1	656	1	ALAS2	23	55042056	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	4664208	55042056	100228504	359	29864											
ARHGEF9	23229	broad.mit.edu	37	chrX	62917154	62917154	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttgctcgtcactgaacatgtCccttctcttccggcactgct	5	14	7	15	2	2	1	1	1	1	0	6	1	4	1	2	1	3	3	2	1	1	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:62917154C>G	uc004dvl.2	-	4	1251	c.412G>C	c.(412-414)GAC>CAC	p.D138H	ARHGEF9_uc004dvj.1_Missense_Mutation_p.D27H|ARHGEF9_uc004dvk.1_5'UTR|ARHGEF9_uc011mos.1_Missense_Mutation_p.D117H|ARHGEF9_uc004dvm.1_Missense_Mutation_p.D117H|ARHGEF9_uc011mot.1_Missense_Mutation_p.D85H|ARHGEF9_uc004dvn.2_Missense_Mutation_p.D145H	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	138	DH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						CTGAACATGTCCCTTCTCTTC	0.408													21	41					0	0	0	0	G	62917154	G	G	62917154	3	3	163	1	0	0	0	0	1	0	0	0	912	855	30	2	1166	2	ARHGEF9	23	62917154	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	7875098	62917154	92353406	360	29865											
FAM123B	139285	broad.mit.edu	37	chrX	63410016	63410016	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcaacaggcagcagcaCatctcgaggcctggccctca	10	6	9	16	1	4	0	3	0	1	0	5	1	4	0	2	3	3	3	2	3	1	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:63410016C>T	uc004dvo.2	-	2	3424	c.3151G>A	c.(3151-3153)GTG>ATG	p.V1051M		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	1051	Pro-rich.				Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GGCAGCAGCACATCTCGAGGC	0.612													9	10					0	0	0	0	T	63410016	T	T	63410016	3	4	163	1	0	0	0	0	1	0	0	0	5451	478	17	4	260	4	FAM123B	23	63410016	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	492862	63410016	91860544	361	29866											
ZMYM3	9203	broad.mit.edu	37	chrX	70468637	70468638	+	Frame_Shift_Ins	INS	-	G	G																															ctgcggcggcagaagctgcaINSgggtcggggagggcctgggg																										TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:70468637_70468638insG	uc004dzh.1	-	9	1722_1723	c.1635_1636insC	c.(1633-1638)CCCTGCfs	p.P545fs	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Frame_Shift_Ins_p.P545fs|ZMYM3_uc004dzj.1_Frame_Shift_Ins_p.P545fs	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	545_546	MYM-type 5.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CAGAAGCTGCAGGGTCGGGGAG	0.45													---	---	---								G	70468638	G	G	70468637	7	5	163	1	0	1	1	0	0	0	0	0	17768	188	7	0	2544	0	ZMYM3	23	70468637	Frame_Shift_Ins	INS	-	TCGA-CR-7398-01A-11D-2012-08	7058621	70468637	84801923	362	29867											
RLIM	51132	broad.mit.edu	37	chrX	73811496	73811496	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cattgccaagttgtcaatctGttctttggtgagtcctctag	7	16	9	9	0	4	1	1	1	3	0	5	1	5	1	2	1	1	2	2	1	3	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:73811496G>T	uc004ebu.2	-	5	1944	c.1654C>A	c.(1654-1656)CAG>AAG	p.Q552K	RLIM_uc004ebw.2_Missense_Mutation_p.Q552K	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	552					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TTGTCAATCTGTTCTTTGGTG	0.393													19	32					7.07596e-05	0.000186736	1	0	T	73811496	T	T	73811496	3	4	163	1	0	0	0	0	1	0	0	0	13455	1386	48	4	224	4	RLIM	23	73811496	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	3342859	73811496	81459064	363	29868											
RLIM	51132	broad.mit.edu	37	chrX	73811508	73811508	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaatctgttctttggtgaGtcctctaggttggtcatcat	6	17	10	8	0	6	1	3	1	3	0	7	1	7	1	1	3	0	2	1	3	2	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:73811508G>C	uc004ebu.2	-	5	1932	c.1642C>G	c.(1642-1644)CTC>GTC	p.L548V	RLIM_uc004ebw.2_Missense_Mutation_p.L548V	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	548					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TCTTTGGTGAGTCCTCTAGGT	0.413													17	30					0	0	0	0	C	73811508	C	C	73811508	3	2	163	1	0	0	0	0	1	0	0	0	13455	1029	36	4	236	4	RLIM	23	73811508	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	12	73811508	81459052	364	29869											
KIAA2022	340533	broad.mit.edu	37	chrX	73963237	73963237	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcctgtccttcctctttGcctttcttcttgtccaagtt	2	21	4	14	0	4	0	0	0	4	0	8	0	8	0	5	0	1	1	5	0	1	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:73963237G>T	uc004eby.2	-	3	1772	c.1155C>A	c.(1153-1155)GGC>GGA	p.G385G		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	385					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CTTCCTCTTTGCCTTTCTTCT	0.458													52	153					1.4374e-25	5.18963e-25	1	0	T	73963237	T	T	73963237	2	4	163	1	0	0	0	0	0	0	0	1	8308	1306	46	4		4	KIAA2022	23	73963237	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	151729	73963237	81307323	365	29870											
TAF9B	51616	broad.mit.edu	37	chrX	77392460	77392460	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagcaccaacacttaatcGtggaactagtctcccttggt	12	10	7	12	1	1	0	0	0	1	0	3	1	1	1	2	2	4	1	2	2	5	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:77392460G>T	uc004eda.2	-	5	504	c.433C>A	c.(433-435)CGA>AGA	p.R145R		NM_015975	NP_057059	Q9HBM6	TAF9B_HUMAN	transcription associated factor 9B	145					negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding				0						ACACTTAATCGTGGAACTAGT	0.408													31	48					1.21669e-08	3.54467e-08	1	0	T	77392460	T	T	77392460	2	4	163	1	0	0	0	0	0	0	0	1	15602	1153	40	3		3	TAF9B	23	77392460	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	3429223	77392460	77878100	366	29871											
KLHL4	56062	broad.mit.edu	37	chrX	86773132	86773132	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tatactggcaccagtgccagGaccggcccctgcccatcaga	9	6	10	16	1	1	1	1	0	0	1	1	2	1	2	6	3	3	1	6	3	2	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:86773132G>T	uc004efb.2	+	1	418	c.236G>T	c.(235-237)GGA>GTA	p.G79V	KLHL4_uc004efa.2_Missense_Mutation_p.G79V	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	79						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CCAGTGCCAGGACCGGCCCCT	0.498													26	41					1.5548e-18	5.25862e-18	1	0	T	86773132	T	T	86773132	3	4	163	1	0	0	0	0	1	0	0	0	8430	1174	41	2	238	2	KLHL4	23	86773132	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	9380672	86773132	68497428	367	29872											
PABPC5	140886	broad.mit.edu	37	chrX	90690670	90690670	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggacccagatgtcaccgagGacatgctctataagaagttc	12	9	10	10	1	2	2	1	0	1	2	3	5	2	4	2	2	1	2	2	2	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:90690670G>T	uc004efg.2	+	2	534	c.94G>T	c.(94-96)GAC>TAC	p.D32Y	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	32	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						TGTCACCGAGGACATGCTCTA	0.567													13	28					4.36969e-10	1.33242e-09	1	0	T	90690670	T	T	90690670	3	4	163	1	0	0	0	0	1	0	0	0	11421	1174	41	2	96	2	PABPC5	23	90690670	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	3917538	90690670	64579890	368	29873											
SYTL4	94121	broad.mit.edu	37	chrX	99931173	99931173	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacttccccattactgatcCctgaggagaaacaccagaag	13	7	7	14	0	0	4	0	2	0	2	2	5	2	4	5	1	2	0	5	1	3	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:99931173C>A	uc004egd.3	-	19	2224	c.1868G>T	c.(1867-1869)GGG>GTG	p.G623V	SYTL4_uc004egc.2_Missense_Mutation_p.G54V|SYTL4_uc010nnb.2_Missense_Mutation_p.G295V|SYTL4_uc010nnc.2_Missense_Mutation_p.G623V|SYTL4_uc004ege.3_Missense_Mutation_p.G623V|SYTL4_uc004egf.3_Missense_Mutation_p.G623V	NM_080737	NP_542775	Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	623					exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			ovary(2)	2					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATTACTGATCCCTGAGGAGAA	0.557													41	63					2.00842e-17	6.75403e-17	1	0	A	99931173	A	A	99931173	3	1	163	1	0	0	0	0	1	0	0	0	15551	637	22	4	151	4	SYTL4	23	99931173	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	9240503	99931173	55339387	369	29874											
NOX1	27035	broad.mit.edu	37	chrX	100125791	100125791	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacaggaaaacattcagccCtaaccaaacaacctagagaa	21	4	5	11	0	1	1	1	0	0	1	1	3	1	2	3	1	6	0	3	1	8	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:100125791C>T	uc004egj.2	-	2	264	c.58G>A	c.(58-60)GGG>AGG	p.G20R	uc010nnf.2_Intron|NOX1_uc004egl.3_Missense_Mutation_p.G20R|NOX1_uc010nne.2_Missense_Mutation_p.G20R	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	20	Helical; (Potential).				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						ACATTCAGCCCTAACCAAACA	0.383													35	61					0	0	0	0	T	100125791	T	T	100125791	3	4	163	1	0	0	0	0	1	0	0	0	10610	681	24	4	1684	4	NOX1	23	100125791	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	194618	100125791	55144769	370	29875											
CENPI	2491	broad.mit.edu	37	chrX	100417906	100417906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttataagaagtagtgttcatCattcttccattcccagagca	12	14	6	9	0	3	2	2	0	1	2	5	2	5	2	2	0	1	3	2	0	4	7			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:100417906C>T	uc004egx.2	+	21	2491	c.2221C>T	c.(2221-2223)CAT>TAT	p.H741Y	CENPI_uc011mrg.1_Missense_Mutation_p.H727Y	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	741					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						TAGTGTTCATCATTCTTCCAT	0.378													39	49					0	0	0	0	T	100417906	T	T	100417906	3	4	163	1	0	0	0	0	1	0	0	0	3248	826	29	2	2299	2	CENPI	23	100417906	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	292115	100417906	54852654	371	29876											
GPRASP1	9737	broad.mit.edu	37	chrX	101912157	101912157	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatctttgcttcagcctgatCagcctagtcctgagttccca	8	13	7	13	0	3	2	2	2	1	0	5	2	5	2	4	0	3	2	4	0	2	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:101912157C>G	uc004ejj.3	+	5	4117	c.3316C>G	c.(3316-3318)CAG>GAG	p.Q1106E	GPRASP1_uc004eji.3_Missense_Mutation_p.Q1106E|GPRASP1_uc010nod.2_Missense_Mutation_p.Q1106E	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1106	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2						TCAGCCTGATCAGCCTAGTCC	0.488													62	120					0	0	0	0	G	101912157	G	G	101912157	3	3	163	1	0	0	0	0	1	0	0	0	6761	827	29	2	3318	2	GPRASP1	23	101912157	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1494251	101912157	53358403	372	29877											
FAM199X	139231	broad.mit.edu	37	chrX	103432977	103432977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtgcagcagagcggattcGggattcaaaagtaaaacgtc	15	7	12	7	3	1	1	1	0	0	1	3	3	1	3	0	2	4	3	0	2	5	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:103432977G>A	uc004elw.2	+	5	1152	c.986G>A	c.(985-987)CGG>CAG	p.R329Q	FAM199X_uc004elx.2_Intron	NM_207318	NP_997201	Q6PEV8	F199X_HUMAN	hypothetical protein LOC139231	329										ovary(1)	1						GAGCGGATTCGGGATTCAAAA	0.398													77	133					0	0	0	0	A	103432977	A	A	103432977	3	1	163	1	0	0	0	0	1	0	0	0	5558	1116	39	1	1004	1	FAM199X	23	103432977	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1520820	103432977	51837583	373	29878											
TEX13A	56157	broad.mit.edu	37	chrX	104464080	104464080	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtttcgaccgaccggagatCtccctccttctgcccccaat	6	11	7	17	3	2	1	0	0	2	1	5	4	3	1	6	1	1	1	6	1	1	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:104464080C>T	uc004ema.2	-	5	908	c.796G>A	c.(796-798)GAT>AAT	p.D266N	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Silent_p.E266E	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	266						intracellular	zinc ion binding			ovary(2)	2						GACCGGAGATCTCCCTCCTTC	0.552													27	42					0	0	0	0	T	104464080	T	T	104464080	3	4	163	1	0	0	0	0	1	0	0	0	15842	912	32	2	437	2	TEX13A	23	104464080	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	1031103	104464080	50806480	374	29879											
MID2	11043	broad.mit.edu	37	chrX	107097876	107097876	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctcaccaacctggttaagcGcaacagcgaactagaaaatc	15	6	7	13	2	1	1	1	0	0	1	2	2	1	1	3	1	5	2	3	1	7	2			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:107097876G>C	uc004enl.2	+	3	1331	c.758G>C	c.(757-759)CGC>CCC	p.R253P	MID2_uc004enk.2_Missense_Mutation_p.R253P	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	253	Potential.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						CTGGTTAAGCGCAACAGCGAA	0.448													33	47					0	0	0	0	C	107097876	C	C	107097876	3	2	163	1	0	0	0	0	1	0	0	0	9631	1087	38	3	768	3	MID2	23	107097876	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2633796	107097876	48172684	375	29880											
IRS4	8471	broad.mit.edu	37	chrX	107977346	107977346	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actctgggaaacatcatcatGtaccctcttgaatcttcaaa	13	12	5	11	0	6	1	3	1	3	0	6	2	6	2	1	1	2	1	1	1	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:107977346G>C	uc004eoc.2	-	1	2262	c.2229C>G	c.(2227-2229)TAC>TAG	p.Y743*		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	743	YXXM motif 4.|CRK-binding.			Y->F: No effect. Reduces interaction with CRK by 50%; when associated with F-779. Abolishes interaction with CRK; when associated with F-700; F-717 and F-779.		plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						ACATCATCATGTACCCTCTTG	0.458													50	88					0	0	0	0	C	107977346	C	C	107977346	4	2	163	1	0	0	0	0	0	1	0	0	7881	1372	48	4	1548	4	IRS4	23	107977346	Nonsense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	879470	107977346	47293214	376	29881											
WDR44	54521	broad.mit.edu	37	chrX	117527102	117527102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggctagtacaaagaagcctGttccagcacgcccacctcct	10	8	8	15	1	0	1	0	0	0	1	2	1	2	1	5	1	3	4	5	1	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:117527102G>A	uc004eqn.2	+	4	1119	c.694G>A	c.(694-696)GTT>ATT	p.V232I	WDR44_uc004eqo.2_Missense_Mutation_p.V232I|WDR44_uc011mtr.1_Missense_Mutation_p.V207I|WDR44_uc010nqi.2_5'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	232	Pro-rich.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						AAAGAAGCCTGTTCCAGCACG	0.517													88	130					0	0	0	0	A	117527102	A	A	117527102	3	1	163	1	0	0	0	0	1	0	0	0	17364	1377	48	4	708	4	WDR44	23	117527102	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	9549756	117527102	37743458	377	29882											
NKRF	55922	broad.mit.edu	37	chrX	118723982	118723982	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctgtcatcctttcatagAcatactcaactgtcattcgg	9	13	7	12	1	4	1	4	0	0	1	6	1	5	1	2	2	2	0	2	2	3	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:118723982A>T	uc004erq.2	-	2	2059	c.1406T>A	c.(1405-1407)GTC>GAC	p.V469D	NKRF_uc004err.2_Missense_Mutation_p.V469D	NM_017544	NP_060014	O15226	NKRF_HUMAN	transcription factor NRF	469					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			ovary(1)|central_nervous_system(1)	2						CCTTTCATAGACATACTCAAC	0.403													52	92					0	0	0	0	T	118723982	T	T	118723982	3	4	163	1	0	0	0	0	1	0	0	0	10501	275	10	5	670	5	NKRF	23	118723982	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	1196880	118723982	36546578	378	29883											
AKAP14	158798	broad.mit.edu	37	chrX	119037469	119037469	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttttgcagaggagcgaaacCctttgaaaaacatcaagtgg	14	10	10	7	1	1	2	1	1	0	1	1	4	1	3	1	2	4	1	1	2	4	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:119037469C>G	uc004ese.2	+	4	319	c.181C>G	c.(181-183)CCT>GCT	p.P61A	AKAP14_uc004esd.2_Missense_Mutation_p.P61A|AKAP14_uc004esf.2_Missense_Mutation_p.P61A	NM_178813	NP_848928	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14 isoform a	61						cytoplasm					0						GGAGCGAAACCCTTTGAAAAA	0.393													11	32					0	0	0	0	G	119037469	G	G	119037469	3	3	163	1	0	0	0	0	1	0	0	0	450	623	22	4	187	4	AKAP14	23	119037469	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	313487	119037469	36233091	379	29884											
ZBTB33	10009	broad.mit.edu	37	chrX	119388366	119388366	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatacctcccaaaataccAgttttgatggatcattaata	14	13	5	9	0	1	2	1	2	0	0	2	3	2	3	3	1	2	1	3	1	6	6			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:119388366A>T	uc004esn.1	+	2	1324	c.1096A>T	c.(1096-1098)AGT>TGT	p.S366C	ZBTB33_uc010nqm.1_Missense_Mutation_p.S366C	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	366					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CCAAAATACCAGTTTTGATGG	0.373													51	96					0	0	0	0	T	119388366	T	T	119388366	3	4	163	1	0	0	0	0	1	0	0	0	17603	188	7	5	1098	5	ZBTB33	23	119388366	Missense_Mutation	SNP	A	TCGA-CR-7398-01A-11D-2012-08	350897	119388366	35882194	380	29885											
CT47B1	643311	broad.mit.edu	37	chrX	120008943	120008943	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgcggcctcctggaccgaCgcagcctcctggatcaggcc	6	5	13	17	4	1	0	1	0	0	0	3	4	3	2	6	4	1	1	6	4	0	0	rs139114591	by1000genomes	TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:120008943C>A	uc011muc.1	-	1	837	c.582G>T	c.(580-582)GCG>GCT	p.A194A		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	194											0						CCTGGACCGACGCAGCCTCCT	0.706													38	69					8.73648e-17	2.92958e-16	1	0	A	120008943	A	A	120008943	2	1	163	1	0	0	0	0	0	0	0	1	4006	523	19	3		3	CT47B1	23	120008943	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	620577	120008943	35261617	381	29886											
THOC2	57187	broad.mit.edu	37	chrX	122778702	122778702	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcattgcagtccatcaaaGaaagagatggaagtagtacc	17	7	10	7	0	1	2	1	0	0	2	2	4	2	3	2	1	3	4	2	1	6	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:122778702G>A	uc004etu.2	-	14	1519	c.1487C>T	c.(1486-1488)TCT>TTT	p.S496F	THOC2_uc011muh.1_Missense_Mutation_p.S417F|THOC2_uc011mui.1_Missense_Mutation_p.S381F	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	496					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						GTCCATCAAAGAAAGAGATGG	0.333													27	46					0	0	0	0	A	122778702	A	A	122778702	3	1	163	1	0	0	0	0	1	0	0	0	15931	942	33	2	3394	2	THOC2	23	122778702	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2769759	122778702	32491858	382	29887											
ARHGAP36	158763	broad.mit.edu	37	chrX	130215646	130215646	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catccgattccagaatgggtGgctgcattccttttctgaag	8	13	10	10	1	1	2	0	1	1	1	4	3	4	2	3	2	1	2	3	2	2	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:130215646G>T	uc004evz.2	+	2	352	c.7G>T	c.(7-9)GGC>TGC	p.G3C	ARHGAP36_uc004ewa.2_Intron|ARHGAP36_uc004ewb.2_Intron|ARHGAP36_uc004ewc.2_5'Flank	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	3					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						CAGAATGGGTGGCTGCATTCC	0.517													51	74					4.01344e-20	1.37721e-19	1	0	T	130215646	T	T	130215646	3	4	163	1	0	0	0	0	1	0	0	0	883	1348	47	4	9	4	ARHGAP36	23	130215646	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	7436944	130215646	25054914	383	29888											
ARHGAP36	158763	broad.mit.edu	37	chrX	130220538	130220538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atccttcccattcaggagtgCacgcataaagatggaagagg	13	8	11	9	1	1	2	1	0	0	2	3	4	3	4	2	3	1	2	2	3	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:130220538C>T	uc004evz.2	+	11	1730	c.1385C>T	c.(1384-1386)GCA>GTA	p.A462V	ARHGAP36_uc004ewa.2_Missense_Mutation_p.A450V|ARHGAP36_uc004ewb.2_Missense_Mutation_p.A431V|ARHGAP36_uc004ewc.2_Missense_Mutation_p.A326V	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	462					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						TTCAGGAGTGCACGCATAAAG	0.453													37	62					0	0	0	0	T	130220538	T	T	130220538	3	4	163	1	0	0	0	0	1	0	0	0	883	710	25	4	1423	4	ARHGAP36	23	130220538	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	4892	130220538	25050022	384	29889											
MAP7D3	79649	broad.mit.edu	37	chrX	135323385	135323385	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttttttgctgataatcatCagcaagtctcctccgttcca	8	16	5	12	1	4	1	2	1	2	0	7	1	6	1	3	0	2	3	3	0	2	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:135323385C>G	uc004ezt.2	-	5	560	c.469G>C	c.(469-471)GAT>CAT	p.D157H	MAP7D3_uc004ezs.2_Missense_Mutation_p.D156H|MAP7D3_uc011mwc.1_Missense_Mutation_p.D139H|MAP7D3_uc010nsa.1_Missense_Mutation_p.D156H	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	157						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					TGATAATCATCAGCAAGTCTC	0.328													23	36					0	0	0	0	G	135323385	G	G	135323385	3	3	163	1	0	0	0	0	1	0	0	0	9322	826	29	2	2217	2	MAP7D3	23	135323385	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	5102847	135323385	19947175	385	29890											
MAGEC1	9947	broad.mit.edu	37	chrX	140995682	140995682	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttcccagagttctcctgTgagctccttcccctcctcca	4	14	5	18	0	2	2	0	1	2	1	8	2	7	2	7	0	1	2	7	0	0	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:140995682T>A	uc004fbt.2	+	4	2778	c.2492T>A	c.(2491-2493)GTG>GAG	p.V831E	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	831							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGTTCTCCTGTGAGCTCCTTC	0.567										HNSCC(15;0.026)			131	190					0	0	0	0	A	140995682	A	A	140995682	3	1	163	1	0	0	0	0	1	0	0	0	9233	1696	59	5	2498	5	MAGEC1	23	140995682	Missense_Mutation	SNP	T	TCGA-CR-7398-01A-11D-2012-08	5672297	140995682	14274878	386	29891											
MAGEC1	9947	broad.mit.edu	37	chrX	140996136	140996136	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtaaacacattagacctCacctctgaggggtgtctgag	10	12	10	9	0	3	3	1	2	2	1	3	3	3	3	2	2	1	1	2	2	3	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:140996136C>A	uc004fbt.2	+	4	3232	c.2946C>A	c.(2944-2946)CTC>CTA	p.L982L	MAGEC1_uc010nsl.1_Silent_p.L49L	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	982	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CATTAGACCTCACCTCTGAGG	0.473										HNSCC(15;0.026)			70	127					2.23852e-25	8.03276e-25	1	0	A	140996136	A	A	140996136	2	1	163	1	0	0	0	0	0	0	0	1	9233	813	29	2		2	MAGEC1	23	140996136	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	454	140996136	14274424	387	29892											
SPANXN2	494119	broad.mit.edu	37	chrX	142803752	142803752	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccattggtgcttgaagtcGgctgttccatgattctgctt	5	15	10	11	1	1	2	0	2	1	0	3	2	2	2	3	2	2	4	3	2	1	5			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:142803752G>T	uc004fbz.2	-	1	765	c.11C>A	c.(10-12)CCG>CAG	p.P4Q		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	4										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GCTTGAAGTCGGCTGTTCCAT	0.388													76	154					1.20873e-29	4.50215e-29	1	0	T	142803752	T	T	142803752	3	4	163	1	0	0	0	0	1	0	0	0	15057	1116	39	3	539	3	SPANXN2	23	142803752	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	1807616	142803752	12466808	388	29893											
SLITRK2	84631	broad.mit.edu	37	chrX	144906246	144906246	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgagtcaaggaacttcccaGcgcaggcctagtccactata	11	7	10	13	2	1	0	1	0	0	0	3	2	3	1	3	2	2	1	3	2	5	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:144906246G>T	uc004fcd.2	+	5	3293	c.2303G>T	c.(2302-2304)AGC>ATC	p.S768I	SLITRK2_uc010nsp.2_Missense_Mutation_p.S768I|SLITRK2_uc010nso.2_Missense_Mutation_p.S768I|SLITRK2_uc011mwq.1_Missense_Mutation_p.S768I|SLITRK2_uc011mwr.1_Missense_Mutation_p.S768I|SLITRK2_uc011mws.1_Missense_Mutation_p.S768I|SLITRK2_uc004fcg.2_Missense_Mutation_p.S768I|SLITRK2_uc011mwt.1_Missense_Mutation_p.S768I|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	768	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GAACTTCCCAGCGCAGGCCTA	0.463													77	132					3.4779e-39	1.33338e-38	1	0	T	144906246	T	T	144906246	3	4	163	1	0	0	0	0	1	0	0	0	14807	971	34	4	2305	4	SLITRK2	23	144906246	Missense_Mutation	SNP	G	TCGA-CR-7398-01A-11D-2012-08	2102494	144906246	10364314	389	29894											
GPR50	9248	broad.mit.edu	37	chrX	150348250	150348250	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatgtttttcaggcaacatCttcgtggtcagtctctctgt	7	17	8	9	1	5	0	2	0	3	0	7	0	5	0	0	2	1	2	0	2	2	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:150348250C>G	uc010ntg.1	+	2	330	c.195C>G	c.(193-195)ATC>ATG	p.I65M	uc004fes.1_5'Flank|GPR50_uc011myc.1_Missense_Mutation_p.I65M	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	65	Helical; Name=2; (Potential).				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CAGGCAACATCTTCGTGGTCA	0.488													152	317					0	0	0	0	G	150348250	G	G	150348250	3	3	163	1	0	0	0	0	1	0	0	0	6735	903	32	2	201	2	GPR50	23	150348250	Missense_Mutation	SNP	C	TCGA-CR-7398-01A-11D-2012-08	5442004	150348250	4922310	390	29895											
PASD1	139135	broad.mit.edu	37	chrX	150780162	150780162	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatggctttatgattacactGagcacagatggagtgatcat	12	12	11	6	0	1	4	1	3	0	1	1	6	1	5	0	2	2	2	0	2	2	3			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:150780162G>C	uc004fev.3	+	4	476	c.144G>C	c.(142-144)CTG>CTC	p.L48L		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	48	PAS.					nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGATTACACTGAGCACAGATG	0.318													14	75					0	0	0	0	C	150780162	C	C	150780162	2	2	163	1	0	0	0	0	0	0	0	1	11525	1277	45	2		2	PASD1	23	150780162	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	431912	150780162	4490398	391	29896											
PASD1	139135	broad.mit.edu	37	chrX	150791486	150791486	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtgttcctcaggaggatCggctttatcttgtgggaaat	8	14	12	7	1	2	0	1	0	1	0	4	3	3	3	1	4	0	2	1	4	2	4			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:150791486C>A	uc004fev.3	+	7	828	c.496C>A	c.(496-498)CGG>AGG	p.R166R		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	166						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGGAGGATCGGCTTTATCT	0.502													63	104					2.53126e-37	9.67303e-37	1	0	A	150791486	A	A	150791486	2	1	163	1	0	0	0	0	0	0	0	1	11525	875	31	3		3	PASD1	23	150791486	Silent	SNP	C	TCGA-CR-7398-01A-11D-2012-08	11324	150791486	4479074	392	29897											
PASD1	139135	broad.mit.edu	37	chrX	150840134	150840134	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caacagaaacaacacgctggGcaagtgaagcggcctctccc	13	4	10	14	2	1	2	0	1	1	1	2	2	1	2	2	2	4	2	2	2	5	0			TCGA-CR-7398-01A-11D-2012-08	TCGA-CR-7398-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12c391dc-3138-4e73-bdc7-b06512dd0fa7	b36e8d02-d1c2-4cfe-879f-05e2dd5e2032	g.chrX:150840134G>T	uc004fev.3	+	13	1652	c.1320G>T	c.(1318-1320)GGG>GGT	p.G440G		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	440						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AACACGCTGGGCAAGTGAAGC	0.493													64	79					1.88225e-35	7.14649e-35	1	0	T	150840134	T	T	150840134	2	4	163	1	0	0	0	0	0	0	0	1	11525	1190	42	4		4	PASD1	23	150840134	Silent	SNP	G	TCGA-CR-7398-01A-11D-2012-08	48648	150840134	4430426	393	29898											
PANK4	55229	broad.mit.edu	37	chr1	2452658	2452658	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatgaagtccaggcaggcttCgatgtaggtattctcaaact	11	11	11	8	1	1	1	1	1	1	0	4	3	2	1	1	3	1	4	1	3	4	4	rs140699365	by1000genomes	TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:2452658C>T	uc001ajm.1	-	3	313	c.304G>A	c.(304-306)GAA>AAA	p.E102K	PANK4_uc010nza.1_Missense_Mutation_p.E102K	NM_018216	NP_060686	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	102					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		AGGCAGGCTTCGATGTAGGTA	0.507													39	104					0	0	0	0	T	2452658	T	T	2452658	3	4	164	1	0	0	0	0	1	0	0	0	11473	893	31	1	2085	1	PANK4	1	2452658	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08		2452658	246797963	1	29899											
NBPF1	55672	broad.mit.edu	37	chr1	16913608	16913608	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctctgtctacaaccagagTtgagttgactttgtcttcct	7	17	7	10	0	3	3	0	2	3	1	5	3	4	3	2	0	2	2	2	0	2	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:16913608T>C	uc009vos.1	-	11	1603	c.715A>G	c.(715-717)ACT>GCT	p.T239A	NBPF1_uc009vot.1_5'UTR|NBPF1_uc001ayz.1_5'UTR|NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	239	NBPF 1.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ACAACCAGAGTTGAGTTGACT	0.448													4	68					0	0	0	0	C	16913608	C	C	16913608	3	2	164	1	0	0	0	0	1	0	0	0	10245	1725	60	5	2785	5	NBPF1	1	16913608	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	14460950	16913608	232337013	2	29900											
CNKSR1	10256	broad.mit.edu	37	chr1	26510922	26510922	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccttggccctgagcccctgcCcatccccccggaacccccag	5	5	8	23	1	0	1	0	1	0	0	1	2	1	2	10	2	3	0	10	2	1	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:26510922C>T	uc001bln.3	+	12	1110	c.1052C>T	c.(1051-1053)CCC>CTC	p.P351L	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Missense_Mutation_p.P344L|CNKSR1_uc009vsd.2_Missense_Mutation_p.P86L|CNKSR1_uc009vse.2_Missense_Mutation_p.P86L|CNKSR1_uc001blo.2_Missense_Mutation_p.P86L	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	351	Pro-rich.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCCCCTGCCCATCCCCCCG	0.637													6	21					0	0	0	0	T	26510922	T	T	26510922	3	4	164	1	0	0	0	0	1	0	0	0	3621	623	22	4	1077	4	CNKSR1	1	26510922	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	9597314	26510922	222739699	3	29901											
TXLNA	200081	broad.mit.edu	37	chr1	32660790	32660790	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caagagcccacctccgccagGgcctagagagcctggtgttg	8	6	13	14	1	0	2	0	0	0	2	1	3	1	2	6	2	2	1	6	2	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:32660790G>T	uc001bui.2	+	11	1700	c.1635G>T	c.(1633-1635)AGG>AGT	p.R545S	TXLNA_uc001buj.2_Missense_Mutation_p.R545S	NM_175852	NP_787048	P40222	TXLNA_HUMAN	taxilin	545					cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CCTCCGCCAGGGCCTAGAGAG	0.647													18	28					6.94344e-10	1.82772e-09	1	0	T	32660790	T	T	32660790	3	4	164	1	0	0	0	0	1	0	0	0	16855	1223	43	4	1673	4	TXLNA	1	32660790	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	6149868	32660790	216589831	4	29902											
CSMD2	114784	broad.mit.edu	37	chr1	34204749	34204749	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggctcgtaccttcacacCgcagcacagcgctgttccag	8	7	10	16	3	1	0	1	0	0	0	3	0	2	0	3	1	3	7	3	1	1	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:34204749C>T	uc001bxn.1	-	15	2269	c.2240G>A	c.(2239-2241)CGG>CAG	p.R747Q	CSMD2_uc001bxm.1_Missense_Mutation_p.R787Q	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	747	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACCTTCACACCGCAGCACAGC	0.617													8	16					0	0	0	0	T	34204749	T	T	34204749	3	4	164	1	0	0	0	0	1	0	0	0	3962	652	23	1	8443	1	CSMD2	1	34204749	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1543959	34204749	215045872	5	29903											
POU3F1	5453	broad.mit.edu	37	chr1	38511546	38511546	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgaagcggcagatggtggtCtgcgagaacacgttaccgta	10	8	14	9	5	1	2	0	0	1	2	2	4	1	2	1	3	4	3	1	3	4	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:38511546C>G	uc001ccp.1	-	1	905	c.870G>C	c.(868-870)CAG>CAC	p.Q290H		NM_002699	NP_002690	Q03052	PO3F1_HUMAN	POU domain, class 3, transcription factor 1	290	POU-specific.				positive regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AGATGGTGGTCTGCGAGAACA	0.612													15	67					0	0	0	0	G	38511546	G	G	38511546	3	3	164	1	0	0	0	0	1	0	0	0	12329	912	32	2	489	2	POU3F1	1	38511546	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	4306797	38511546	210739075	6	29904											
COL9A2	1298	broad.mit.edu	37	chr1	40767556	40767556	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggatcacccttctctccacGttttcctgtagacaaaaaag	11	12	6	12	1	2	1	1	0	1	1	5	2	4	2	3	1	0	2	3	1	4	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:40767556G>A	uc001cfh.1	-	31	1868	c.1798C>T	c.(1798-1800)CGT>TGT	p.R600C	COL9A2_uc001cfi.1_Missense_Mutation_p.R419C	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	600	Triple-helical region 2 (COL2).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			TTCTCTCCACGTTTTCCTGTA	0.488													5	18					0	0	0	0	A	40767556	A	A	40767556	3	1	164	1	0	0	0	0	1	0	0	0	3723	1145	40	1	279	1	COL9A2	1	40767556	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2256010	40767556	208483065	7	29905											
ROR1	4919	broad.mit.edu	37	chr1	64644143	64644143	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagattgctggtttcattGgcccgccaatacctcagaac	9	10	9	13	1	2	2	2	0	0	2	2	2	2	2	4	2	3	2	4	2	3	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:64644143G>T	uc001dbj.2	+	9	2818	c.2419G>T	c.(2419-2421)GGC>TGC	p.G807C	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	807	Cytoplasmic (Potential).|Pro-rich.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						TGGTTTCATTGGCCCGCCAAT	0.517													15	38					4.14922e-12	1.14327e-11	1	0	T	64644143	T	T	64644143	3	4	164	1	0	0	0	0	1	0	0	0	13591	1348	47	4	2461	4	ROR1	1	64644143	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	23876587	64644143	184606478	8	29906											
LRRC7	57554	broad.mit.edu	37	chr1	70460276	70460276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactaacaactctaaaagtaGatgacaatcaacttacaatg	20	9	4	8	0	2	2	1	1	1	1	2	2	2	2	0	0	5	1	0	0	10	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:70460276G>A	uc001dep.2	+	9	880	c.850G>A	c.(850-852)GAT>AAT	p.D284N	LRRC7_uc009wbg.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	284	LRR 12.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TCTAAAAGTAGATGACAATCA	0.328													14	64					0	0	0	0	A	70460276	A	A	70460276	3	1	164	1	0	0	0	0	1	0	0	0	9070	942	33	2	884	2	LRRC7	1	70460276	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	5816133	70460276	178790345	9	29907											
FAM73A	374986	broad.mit.edu	37	chr1	78324717	78324717	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catgcatttagttgaagaagGaaaaatttactccagagtac	16	11	8	6	0	0	3	0	1	0	2	1	4	1	4	1	1	3	3	1	1	7	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:78324717G>T	uc001dhx.2	+	9	1123	c.1091G>T	c.(1090-1092)GGA>GTA	p.G364V	FAM73A_uc010ork.1_Missense_Mutation_p.G364V|FAM73A_uc010orl.1_Missense_Mutation_p.G326V|FAM73A_uc001dhy.1_Missense_Mutation_p.G153V	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	364						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		GTTGAAGAAGGAAAAATTTAC	0.383													6	35					3.59834e-05	8.03593e-05	1	0	T	78324717	T	T	78324717	3	4	164	1	0	0	0	0	1	0	0	0	5649	1174	41	2	1125	2	FAM73A	1	78324717	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	7864441	78324717	170925904	10	29908											
F3	2152	broad.mit.edu	37	chr1	94997876	94997876	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atggctggcagagccactcaCctctgaattcccctttctcc	7	11	7	16	0	3	2	1	1	2	1	5	2	4	2	5	2	1	2	5	2	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:94997876C>T	uc001dqr.2	-	5	930	c.751_splice	c.e5+1	p.E251_splice	F3_uc001dqp.2_Splice_Site|F3_uc001dqq.2_Intron|F3_uc001dqs.2_Intron	NM_001993	NP_001984	P13726	TF_HUMAN	coagulation factor III precursor						activation of caspase activity|activation of plasma proteins involved in acute inflammatory response|anti-apoptosis|blood coagulation, extrinsic pathway|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of protein kinase B signaling cascade	extracellular matrix|extracellular space|integral to membrane	cell surface binding|phospholipid binding|protease binding			central_nervous_system(1)	1		all_lung(203;0.00106)|Lung NSC(277;0.00475)		all cancers(265;0.0232)|Epithelial(280;0.121)	Coagulation factor VIIa(DB00036)	GAGCCACTCACCTCTGAATTC	0.542													16	54					0	0	0	0	T	94997876	T	T	94997876	5	4	164	1	0	0	0	0	0	0	1	0	5372	521	18	4	143	4	F3	1	94997876	Splice_Site	SNP	C	TCGA-CR-7399-01A-11D-2012-08	16673159	94997876	154252745	11	29909											
F3	2152	broad.mit.edu	37	chr1	94997899	94997899	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgaattcccctttctcctgGcccatacactctaccgggct	6	12	6	17	1	2	1	0	1	2	0	4	1	3	1	5	2	2	1	5	2	3	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:94997899G>T	uc001dqr.2	-	5	908	c.729C>A	c.(727-729)GGC>GGA	p.G243G	F3_uc001dqp.2_RNA|F3_uc001dqq.2_Intron|F3_uc001dqs.2_Intron	NM_001993	NP_001984	P13726	TF_HUMAN	coagulation factor III precursor	243	Extracellular (Potential).				activation of caspase activity|activation of plasma proteins involved in acute inflammatory response|anti-apoptosis|blood coagulation, extrinsic pathway|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of protein kinase B signaling cascade	extracellular matrix|extracellular space|integral to membrane	cell surface binding|phospholipid binding|protease binding			central_nervous_system(1)	1		all_lung(203;0.00106)|Lung NSC(277;0.00475)		all cancers(265;0.0232)|Epithelial(280;0.121)	Coagulation factor VIIa(DB00036)	CTTTCTCCTGGCCCATACACT	0.532													17	62					1.78486e-19	5.25848e-19	1	0	T	94997899	T	T	94997899	2	4	164	1	0	0	0	0	0	0	0	1	5372	1190	42	4		4	F3	1	94997899	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	23	94997899	154252722	12	29910											
IVL	3713	broad.mit.edu	37	chr1	152882573	152882573	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcatgaggaatatcagaaAgcagaaaacccagagcagca	19	3	10	9	0	1	4	1	1	0	3	1	5	1	5	1	1	5	4	1	1	5	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:152882573A>G	uc001fau.2	+	2	346	c.300A>G	c.(298-300)AAA>AAG	p.K100K		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	100					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AATATCAGAAAGCAGAAAACC	0.323													16	32					0	0	0	0	G	152882573	G	G	152882573	2	3	164	1	0	0	0	0	0	0	0	1	7968	69	3	5		5	IVL	1	152882573	Silent	SNP	A	TCGA-CR-7399-01A-11D-2012-08	57884674	152882573	96368048	13	29911											
PEAR1	375033	broad.mit.edu	37	chr1	156882415	156882415	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggtgcaccttgcaggattgGtgagttctttgccctctcct	4	15	11	11	0	2	1	0	1	2	0	3	2	2	2	3	3	3	3	3	3	0	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:156882415G>T	uc001fqj.1	+	17	2325	c.2209_splice	c.e17+1	p.G737_splice	PEAR1_uc001fqk.1_Splice_Site_p.G362_splice	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1							integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGCAGGATTGGTGAGTTCTTT	0.602													37	36					4.62619e-21	1.37351e-20	1	0	T	156882415	T	T	156882415	5	4	164	1	0	0	0	0	0	0	1	0	11766	1275	44	4	2272	4	PEAR1	1	156882415	Splice_Site	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3999842	156882415	92368206	14	29912											
SPTA1	6708	broad.mit.edu	37	chr1	158641851	158641851	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggacccctcccgttacctCttgtctactcatccaactgt	7	13	5	16	1	3	0	1	0	2	0	5	1	5	1	5	1	3	1	5	1	3	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:158641851C>A	uc001fst.1	-	11	1685	c.1486G>T	c.(1486-1488)GAG>TAG	p.E496*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	496	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCCGTTACCTCTTGTCTACTC	0.493													40	47					3.7052e-28	1.13075e-27	1	0	A	158641851	A	A	158641851	4	1	164	1	0	0	0	0	0	1	0	0	15182	922	32	2	5941	2	SPTA1	1	158641851	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1759436	158641851	90608770	15	29913											
LRRC52	440699	broad.mit.edu	37	chr1	165532977	165532977	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgagtgaagaagatgaggaCgaggccgggactagggtgga	12	5	19	5	3	0	4	0	2	0	2	1	9	0	7	1	5	0	0	1	5	3	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:165532977C>T	uc001gde.2	+	2	914	c.858C>T	c.(856-858)GAC>GAT	p.D286D	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	286	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					AAGATGAGGACGAGGCCGGGA	0.572													5	50					0	0	0	0	T	165532977	T	T	165532977	2	4	164	1	0	0	0	0	0	0	0	1	9060	535	19	1		1	LRRC52	1	165532977	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	6891126	165532977	83717644	16	29914											
SELP	6403	broad.mit.edu	37	chr1	169565302	169565302	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcccggatgatgcctacaGtacatggttccctgcccagg	7	10	11	13	1	0	1	0	1	0	0	2	2	2	2	4	3	4	3	4	3	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:169565302G>T	uc001ggi.3	-	12	2027	c.1962C>A	c.(1960-1962)TAC>TAA	p.Y654*	SELP_uc001ggh.2_Nonsense_Mutation_p.Y489*|SELP_uc009wvr.2_Nonsense_Mutation_p.Y654*	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	654	Extracellular (Potential).|Sushi 8.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GATGCCTACAGTACATGGTTC	0.498													61	238					5.10652e-33	1.56464e-32	1	0	T	169565302	T	T	169565302	4	4	164	1	0	0	0	0	0	1	0	0	14084	1024	36	4	550	4	SELP	1	169565302	Nonsense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	4032325	169565302	79685319	17	29915											
SELP	6403	broad.mit.edu	37	chr1	169572435	169572435	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attctgagggcttagcaaagGtgtgcagggaatggctatca	11	10	14	6	0	2	1	1	1	1	0	2	2	2	2	0	4	2	4	0	4	4	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:169572435G>T	uc001ggi.3	-	10	1599	c.1534C>A	c.(1534-1536)CCT>ACT	p.P512T	SELP_uc001ggh.2_Missense_Mutation_p.P347T|SELP_uc009wvr.2_Missense_Mutation_p.P512T	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	512	Extracellular (Potential).|Sushi 6.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CTTAGCAAAGGTGTGCAGGGA	0.383													42	68					2.24722e-20	6.64622e-20	1	0	T	169572435	T	T	169572435	3	4	164	1	0	0	0	0	1	0	0	0	14084	1261	44	4	986	4	SELP	1	169572435	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	7133	169572435	79678186	18	29916											
VASH2	79805	broad.mit.edu	37	chr1	213134597	213134597	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aattacatgaagaccctacaGtatccttccaaccaaggtct	14	10	5	12	0	1	2	0	1	1	1	3	2	3	2	4	1	3	1	4	1	7	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:213134597G>T	uc001hjy.2	+	2	569	c.365_splice	c.e2+1	p.Q122_splice	VASH2_uc001hju.2_Splice_Site_p.Q122_splice|VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Splice_Site_p.Q57_splice|VASH2_uc010ptn.1_Splice_Site_p.Q18_splice|VASH2_uc001hjw.2_Splice_Site_p.H122_splice	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3						positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		AGACCCTACAGTATCCTTCCA	0.537													46	89					7.05121e-23	2.11813e-22	1	0	T	213134597	T	T	213134597	5	4	164	1	0	0	0	0	0	0	1	0	17194	1043	36	4	372	4	VASH2	1	213134597	Splice_Site	SNP	G	TCGA-CR-7399-01A-11D-2012-08	43562162	213134597	36116024	19	29917											
SMYD2	56950	broad.mit.edu	37	chr1	214488115	214488115	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcttcccagaaagaagattGgcccatgcacaagctggaat	14	8	9	10	0	1	3	0	0	1	3	2	4	2	4	2	2	2	2	2	2	4	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:214488115G>A	uc010ptx.1	+	3	281	c.248G>A	c.(247-249)TGG>TAG	p.W83*	SMYD2_uc009xdj.2_5'UTR|SMYD2_uc010ptw.1_RNA|SMYD2_uc009xdl.1_RNA	NM_020197	NP_064582	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	83	MYND-type.				negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		AAAGAAGATTGGCCCATGCAC	0.428													10	52					0	0	0	0	A	214488115	A	A	214488115	4	1	164	1	0	0	0	0	0	1	0	0	14886	1357	47	4	258	4	SMYD2	1	214488115	Nonsense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1353518	214488115	34762506	20	29918											
USH2A	7399	broad.mit.edu	37	chr1	215987092	215987092	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcacctggtagaattctaGcgtaatacccagagcagcac	12	8	8	13	1	2	2	1	0	1	2	2	2	2	2	3	1	4	4	3	1	5	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:215987092G>C	uc001hku.1	-	49	10112	c.9725C>G	c.(9724-9726)GCT>GGT	p.A3242G		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3242	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAGAATTCTAGCGTAATACCC	0.418										HNSCC(13;0.011)			13	60					0	0	0	0	C	215987092	C	C	215987092	3	2	164	1	0	0	0	0	1	0	0	0	17104	971	34	4	5979	4	USH2A	1	215987092	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1498977	215987092	33263529	21	29919											
USH2A	7399	broad.mit.edu	37	chr1	216595476	216595476	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagcagcagcagagctgTgacaaaaagtgcttcggtct	11	10	11	9	1	2	2	1	1	1	1	3	2	2	2	0	1	5	5	0	1	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:216595476T>A	uc001hku.1	-	2	590	c.203A>T	c.(202-204)CAC>CTC	p.H68L	USH2A_uc001hkv.2_Missense_Mutation_p.H68L	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	68	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGCAGAGCTGTGACAAAAAGT	0.493										HNSCC(13;0.011)			21	26					0	0	0	0	A	216595476	A	A	216595476	3	1	164	1	0	0	0	0	1	0	0	0	17104	1696	59	5	15703	5	USH2A	1	216595476	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	608384	216595476	32655145	22	29920											
SLC30A10	55532	broad.mit.edu	37	chr1	220089179	220089179	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggcatcttgatatcccCtgtccttaggatacttgatg	7	15	9	10	0	1	2	0	2	1	0	3	3	3	3	3	2	2	2	3	2	3	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:220089179C>A	uc001hlw.2	-	4	1281	c.1070G>T	c.(1069-1071)AGG>ATG	p.R357M	SLC30A10_uc001hlu.1_Intron|SLC30A10_uc001hlv.2_Missense_Mutation_p.R112M|SLC30A10_uc001hlx.2_Missense_Mutation_p.R132M	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),	357	Cytoplasmic (Potential).				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		TTGATATCCCCTGTCCTTAGG	0.453													19	99					3.51602e-12	9.72299e-12	1	0	A	220089179	A	A	220089179	3	1	164	1	0	0	0	0	1	0	0	0	14618	681	24	4	391	4	SLC30A10	1	220089179	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	3493703	220089179	29161442	23	29921											
HHIPL2	79802	broad.mit.edu	37	chr1	222721186	222721186	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgtgctgatcacagcagccGaaggactcatagtcagagca	12	8	11	10	1	3	2	3	1	0	1	3	4	3	3	1	1	4	3	1	1	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:222721186G>A	uc001hnh.1	-	1	259	c.201C>T	c.(199-201)TTC>TTT	p.F67F		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	67					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CACAGCAGCCGAAGGACTCAT	0.567													8	43					0	0	0	0	A	222721186	A	A	222721186	2	1	164	1	0	0	0	0	0	0	0	1	7133	1049	37	1		1	HHIPL2	1	222721186	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2632007	222721186	26529435	24	29922											
URB2	9816	broad.mit.edu	37	chr1	229773042	229773042	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggagagcagttggaaagcatCctggggcttttggaagtgat	10	10	16	5	0	0	2	0	1	0	1	1	5	1	4	1	5	2	4	1	5	2	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:229773042C>T	uc001hts.1	+	4	2818	c.2682C>T	c.(2680-2682)ATC>ATT	p.I894I	URB2_uc009xfd.1_Silent_p.I894I	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	894						nucleolus				central_nervous_system(2)|ovary(1)	3						TGGAAAGCATCCTGGGGCTTT	0.498													54	85					0	0	0	0	T	229773042	T	T	229773042	2	4	164	1	0	0	0	0	0	0	0	1	17093	845	30	2		2	URB2	1	229773042	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	7051856	229773042	19477579	25	29923											
HEATR1	55127	broad.mit.edu	37	chr1	236729217	236729217	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgacacccgatctacgcttAccttctttttcctctggcag	6	14	7	14	2	3	1	0	1	3	0	4	2	4	1	3	1	2	2	3	1	2	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:236729217A>T	uc001hyd.1	-	31	4560	c.4435_splice	c.e31+1	p.E1479_splice	HEATR1_uc009xgh.1_Splice_Site_p.E641_splice	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28						rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ATCTACGCTTACCTTCTTTTT	0.383													17	46					0	0	0	0	T	236729217	T	T	236729217	5	4	164	1	0	0	0	0	0	0	1	0	7066	405	14	5	2057	5	HEATR1	1	236729217	Splice_Site	SNP	A	TCGA-CR-7399-01A-11D-2012-08	6956175	236729217	12521404	26	29924											
RYR2	6262	broad.mit.edu	37	chr1	237777666	237777666	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgatgagaacaaaaaacaCggccttccagggatcggcct	13	6	10	12	2	0	2	0	2	0	1	2	4	1	3	4	3	2	0	4	3	4	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:237777666C>A	uc001hyl.1	+	37	5358	c.5238C>A	c.(5236-5238)CAC>CAA	p.H1746Q		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1746	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACAAAAAACACGGCCTTCCAG	0.517													12	38					3.07112e-06	7.21618e-06	1	0	A	237777666	A	A	237777666	3	1	164	1	0	0	0	0	1	0	0	0	13834	535	19	3	5384	3	RYR2	1	237777666	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1048449	237777666	11472955	27	29925											
FMN2	56776	broad.mit.edu	37	chr1	240371390	240371390	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccacctccccctctacccgGagcgggcataccccctccgc	5	5	7	24	3	1	0	0	0	1	0	3	1	3	1	8	2	3	1	8	2	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:240371390G>T	uc010pyd.1	+	5	3503	c.3278G>T	c.(3277-3279)GGA>GTA	p.G1093V	FMN2_uc010pye.1_Missense_Mutation_p.G1097V	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1093	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTCTACCCGGAGCGGGCATA	0.726													5	22					0.00198382	0.00410704	1	0	T	240371390	T	T	240371390	3	4	164	1	0	0	0	0	1	0	0	0	5982	1174	41	2	3296	2	FMN2	1	240371390	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2593724	240371390	8879231	28	29926											
CEP170	9859	broad.mit.edu	37	chr1	243349134	243349134	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgttgggattctctaactCaatggtataagtacccttgt	10	15	8	8	0	2	0	1	0	1	0	3	1	2	1	1	2	2	3	1	2	5	7			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:243349134C>A	uc001hzs.2	-	10	1921	c.1513G>T	c.(1513-1515)GAG>TAG	p.E505*	CEP170_uc001hzt.2_Intron|CEP170_uc001hzu.2_Intron	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	505						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TTCTCTAACTCAATGGTATAA	0.353													24	107					9.78306e-22	2.92728e-21	1	0	A	243349134	A	A	243349134	4	1	164	1	0	0	0	0	0	1	0	0	3265	835	29	2	3315	2	CEP170	1	243349134	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2977744	243349134	5901487	29	29927											
KIF26B	55083	broad.mit.edu	37	chr1	245849896	245849896	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcagcggggtcctggacaGcggccgccccaccagcatca	8	4	12	17	3	2	0	2	0	0	0	3	1	3	1	5	4	3	1	5	4	0	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:245849896G>A	uc001ibf.1	+	12	4051	c.3611G>A	c.(3610-3612)AGC>AAC	p.S1204N	KIF26B_uc001ibg.1_Missense_Mutation_p.S822N|KIF26B_uc001ibh.1_Missense_Mutation_p.S446N	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1204					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GTCCTGGACAGCGGCCGCCCC	0.657													4	13					0	0	0	0	A	245849896	A	A	245849896	3	1	164	1	0	0	0	0	1	0	0	0	8334	971	34	4	3657	4	KIF26B	1	245849896	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2500762	245849896	3400725	30	29928											
NLRP3	114548	broad.mit.edu	37	chr1	247599410	247599410	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaattttatgtgaaaaagcCaagaatccacagtgtaacct	16	10	7	8	0	0	2	0	1	0	1	1	2	1	2	3	0	2	2	3	0	7	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:247599410C>A	uc001icr.2	+	8	2775	c.2637C>A	c.(2635-2637)GCC>GCA	p.A879A	NLRP3_uc001ics.2_Intron|NLRP3_uc001icu.2_Silent_p.A879A|NLRP3_uc001icw.2_Silent_p.A822A|NLRP3_uc001icv.2_Intron|NLRP3_uc010pyw.1_Silent_p.A857A	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	879					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GTGAAAAAGCCAAGAATCCAC	0.438													17	29					6.94344e-10	1.82772e-09	1	0	A	247599410	A	A	247599410	2	1	164	1	0	0	0	0	0	0	0	1	10532	581	21	4		4	NLRP3	1	247599410	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1749514	247599410	1651211	31	29929											
OR2M4	26245	broad.mit.edu	37	chr1	248402450	248402450	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttatggacctcatgctcAtctgcaccactctacccaag	9	10	5	17	0	4	0	2	0	2	0	4	1	4	1	4	1	3	2	4	1	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:248402450A>T	uc010pzh.1	+	1	220	c.220A>T	c.(220-222)ATC>TTC	p.I74F		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCTCATGCTCATCTGCACCAC	0.458													18	86					0	0	0	0	T	248402450	T	T	248402450	3	4	164	1	0	0	0	0	1	0	0	0	11066	217	8	5	222	5	OR2M4	1	248402450	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	803040	248402450	848171	32	29930											
OR2T6	254879	broad.mit.edu	37	chr1	248551255	248551255	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggctgaattcttcctgctgGggctcatggcctatgaccgc	5	11	13	12	1	2	2	1	2	1	0	3	2	3	2	3	4	1	3	3	4	2	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr1:248551255G>C	uc001iei.1	+	1	346	c.346G>C	c.(346-348)GGG>CGG	p.G116R		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTTCCTGCTGGGGCTCATGGC	0.567													18	62					0	0	0	0	C	248551255	C	C	248551255	3	2	164	1	0	0	0	0	1	0	0	0	11083	1232	43	4	348	4	OR2T6	1	248551255	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	148805	248551255	699366	33	29931											
SDC1	6382	broad.mit.edu	37	chr2	20402571	20402571	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgggcttctggtaggcccCgccgttggcttgtttcggct	1	13	16	11	3	1	0	0	0	1	0	2	0	1	0	3	6	0	6	3	6	1	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:20402571C>A	uc002rdo.1	-	5	1188	c.889G>T	c.(889-891)GGG>TGG	p.G297W	SDC1_uc002rdp.1_Missense_Mutation_p.G297W|SDC1_uc010exv.2_Intron	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	297	Cytoplasmic (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)|skin(1)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		TGGTAGGCCCCGCCGTTGGCT	0.602													7	253					0.00198382	0.00410704	1	0	A	20402571	A	A	20402571	3	1	164	1	0	0	0	0	1	0	0	0	14016	652	23	3	47	3	SDC1	2	20402571	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08		20402571	222796802	34	29932											
C2orf44	80304	broad.mit.edu	37	chr2	24253907	24253908	+	Frame_Shift_Del	DEL	AA	-	-																															aacagcacctggactgtgagAaaaagagtctctgaagacat																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:24253907_24253908delAA	uc002rep.2	-	4	2192_2193	c.2061_2062delTT	c.(2059-2064)TTTTCTfs	p.F687fs	C2orf44_uc010eya.2_3'UTR	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	687_688							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGACTGTGAGAAAAAGAGTCTC	0.475													---	---	---								-	24253908	-	-	24253907	7	5	164	1	0	1	0	1	0	0	0	0	2178	246	9	0	107	0	C2orf44	2	24253907	Frame_Shift_Del	DEL	AA	TCGA-CR-7399-01A-11D-2012-08	3851336	24253907	218945466	35	29933											
DNMT3A	1788	broad.mit.edu	37	chr2	25469921	25469921	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagcagggacactcaccTgcaggacctcgtagatggct	9	7	11	14	1	1	1	1	0	0	1	3	3	2	3	3	3	2	4	3	3	1	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:25469921T>A	uc002rgc.2	-	9	1378	c.1121A>T	c.(1120-1122)CAG>CTG	p.Q374L	DNMT3A_uc002rgd.2_Missense_Mutation_p.Q374L|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.Q185L	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	374	Interaction with DNMT1 and DNMT3B.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GACACTCACCTGCAGGACCTC	0.602			Mis|F|N|S		AML								6	31					0	0	0	0	A	25469921	A	A	25469921	3	1	164	1	0	0	0	0	1	0	0	0	4698	1594	55	5	1677	5	DNMT3A	2	25469921	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	1216014	25469921	217729452	36	29934											
GPR75	10936	broad.mit.edu	37	chr2	54081598	54081598	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ataacacaaaggtgaacatgGgggctgtcactccacaaatg	15	7	10	9	0	1	1	1	1	0	0	2	1	2	1	1	3	2	1	1	3	4	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:54081598G>A	uc002rxo.3	-	2	567	c.296C>T	c.(295-297)CCC>CTC	p.P99L	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	99	Helical; Name=2; (Potential).|Phe-rich.					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GGTGAACATGGGGGCTGTCAC	0.458													7	95					0	0	0	0	A	54081598	A	A	54081598	3	1	164	1	0	0	0	0	1	0	0	0	6746	1232	43	4	1330	4	GPR75	2	54081598	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	28611677	54081598	189117775	37	29935											
PLEK	5341	broad.mit.edu	37	chr2	68613641	68613641	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtcccatctaggtaactgCgtcattgattggctggtatc	7	14	11	9	1	2	1	1	1	1	0	4	1	3	1	1	4	2	3	1	4	3	5	rs151222226		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:68613641C>T	uc002sen.3	+	5	642	c.480C>T	c.(478-480)TGC>TGT	p.C160C	PLEK_uc010fde.2_Silent_p.C160C	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	160	DEP.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		TAGGTAACTGCGTCATTGATT	0.532													11	36					0	0	0	0	T	68613641	T	T	68613641	2	4	164	1	0	0	0	0	0	0	0	1	12108	776	27	1		1	PLEK	2	68613641	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	14532043	68613641	174585732	38	29936											
C2orf78	388960	broad.mit.edu	37	chr2	74043891	74043891	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctcaaaatcaatttctaatCcaagacttcagcctccaacc	14	10	2	15	0	4	1	3	0	1	1	6	1	6	1	5	0	2	0	5	0	6	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:74043891C>A	uc002sjr.1	+	3	2662	c.2541C>A	c.(2539-2541)ATC>ATA	p.I847I		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	847										ovary(2)	2						AATTTCTAATCCAAGACTTCA	0.527													20	79					0.000132079	0.000290725	1	0	A	74043891	A	A	74043891	2	1	164	1	0	0	0	0	0	0	0	1	2205	845	30	2		2	C2orf78	2	74043891	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	5430250	74043891	169155482	39	29937											
LRRTM4	80059	broad.mit.edu	37	chr2	77746278	77746278	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggctaatggagcgaatcctGttccattgtaagtaaattga	12	13	10	6	1	0	1	0	1	0	0	2	3	2	2	2	2	1	4	2	2	5	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:77746278G>T	uc002snr.2	-	3	1132	c.717C>A	c.(715-717)AAC>AAA	p.N239K	LRRTM4_uc002snq.2_Missense_Mutation_p.N239K|LRRTM4_uc002sns.2_Missense_Mutation_p.N239K|LRRTM4_uc002snt.2_Missense_Mutation_p.N240K	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	239	LRR 8.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		AGCGAATCCTGTTCCATTGTA	0.448													3	20					0.004672	0.00959451	1	0	T	77746278	T	T	77746278	3	4	164	1	0	0	0	0	1	0	0	0	9092	1368	48	4	1069	4	LRRTM4	2	77746278	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3702387	77746278	165453095	40	29938											
CTNNA2	1496	broad.mit.edu	37	chr2	80101253	80101253	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcagccgcccgaggggctCtgaagaagaatgccacaatg	11	5	14	11	2	1	3	0	1	1	2	1	4	1	3	3	3	2	2	3	3	4	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:80101253C>G	uc010ysh.1	+	5	642	c.637C>G	c.(637-639)CTG>GTG	p.L213V	CTNNA2_uc010yse.1_Missense_Mutation_p.L213V|CTNNA2_uc010ysf.1_Missense_Mutation_p.L213V|CTNNA2_uc010ysg.1_Missense_Mutation_p.L213V	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	213					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CCGAGGGGCTCTGAAGAAGAA	0.517													13	35					0	0	0	0	G	80101253	G	G	80101253	3	3	164	1	0	0	0	0	1	0	0	0	4030	912	32	2	655	2	CTNNA2	2	80101253	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2354975	80101253	163098120	41	29939											
LRRTM1	347730	broad.mit.edu	37	chr2	80529767	80529767	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccccgccgtccgcgagcGtggtggccgagctggcaggg	3	5	17	16	6	0	0	0	0	0	0	2	2	2	0	6	4	2	2	6	4	0	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:80529767G>T	uc002sok.1	-	2	1448	c.1178C>A	c.(1177-1179)ACG>AAG	p.T393K	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	393	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GTCCGCGAGCGTGGTGGCCGA	0.716										HNSCC(69;0.2)			11	32					1.5842e-08	3.99177e-08	1	0	T	80529767	T	T	80529767	3	4	164	1	0	0	0	0	1	0	0	0	9089	1145	40	3	394	3	LRRTM1	2	80529767	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	428514	80529767	162669606	42	29940											
SLC9A2	6549	broad.mit.edu	37	chr2	103324786	103324786	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaaaagggcacccagacGtcaggcttactacagcagcc	14	4	11	12	1	1	2	1	0	0	2	1	3	1	2	2	2	4	3	2	2	4	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:103324786G>C	uc002tca.2	+	12	2419	c.2277G>C	c.(2275-2277)ACG>ACC	p.T759T		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	759	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						GCACCCAGACGTCAGGCTTAC	0.552													33	75					0	0	0	0	C	103324786	C	C	103324786	2	2	164	1	0	0	0	0	0	0	0	1	14776	1132	40	3		3	SLC9A2	2	103324786	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	22795019	103324786	139874587	43	29941											
CCDC138	165055	broad.mit.edu	37	chr2	109405345	109405345	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggagataaagttggttcAtcgttaaaatattctgatga	13	15	9	4	1	3	3	1	2	2	1	4	4	3	3	0	2	0	3	0	2	5	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:109405345A>T	uc002ten.1	+	3	249	c.189A>T	c.(187-189)TCA>TCT	p.S63S	CCDC138_uc002teo.1_Silent_p.S63S|CCDC138_uc002tep.1_5'UTR|CCDC138_uc010fjm.1_5'UTR	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	63											0						AAGTTGGTTCATCGTTAAAAT	0.358													18	39					0	0	0	0	T	109405345	T	T	109405345	2	4	164	1	0	0	0	0	0	0	0	1	2784	204	8	5		5	CCDC138	2	109405345	Silent	SNP	A	TCGA-CR-7399-01A-11D-2012-08	6080559	109405345	133794028	44	29942											
BUB1	699	broad.mit.edu	37	chr2	111417591	111417591	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccactctgtggcttgaattCatgagtactcttattcacac	9	15	6	11	0	4	2	2	2	2	0	5	2	5	2	1	1	1	2	1	1	3	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:111417591C>T	uc002tgc.2	-	11	1352	c.1240G>A	c.(1240-1242)GAA>AAA	p.E414K	BUB1_uc010yxh.1_Missense_Mutation_p.E394K|BUB1_uc010fkb.2_Missense_Mutation_p.E414K	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	414					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		GGCTTGAATTCATGAGTACTC	0.308													5	21					0	0	0	0	T	111417591	T	T	111417591	3	4	164	1	0	0	0	0	1	0	0	0	1575	835	29	2	2077	2	BUB1	2	111417591	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2012246	111417591	131781782	45	29943											
DPP10	57628	broad.mit.edu	37	chr2	116497460	116497460	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccaaaggaaagcagtatccGtatcctaaggtaagtaacat	16	8	8	9	1	0	0	0	0	0	0	2	1	2	1	3	2	2	5	3	2	7	5	rs146251151		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:116497460G>T	uc002tla.1	+	9	1300	c.843G>T	c.(841-843)CCG>CCT	p.P281P	DPP10_uc002tlb.1_Silent_p.P231P|DPP10_uc002tlc.1_Silent_p.P277P|DPP10_uc002tle.2_Silent_p.P285P|DPP10_uc002tlf.1_Silent_p.P274P	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	281	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AGCAGTATCCGTATCCTAAGG	0.423													12	47					7.03913e-09	1.79732e-08	1	0	T	116497460	T	T	116497460	2	4	164	1	0	0	0	0	0	0	0	1	4749	1132	40	3		3	DPP10	2	116497460	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	5079869	116497460	126701913	46	29944											
INHBB	3625	broad.mit.edu	37	chr2	121107420	121107420	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcaagcgggacgtgcccaaCatgattgtggaggagtgcgg	9	7	17	8	3	1	1	1	1	0	0	1	4	1	4	1	4	4	0	1	4	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:121107420C>A	uc002tmn.2	+	2	1240	c.1194C>A	c.(1192-1194)AAC>AAA	p.N398K		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	398					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)				ACGTGCCCAACATGATTGTGG	0.632													3	19					2.56e-06	6.07108e-06	1	0	A	121107420	A	A	121107420	3	1	164	1	0	0	0	0	1	0	0	0	7781	477	17	4	1200	4	INHBB	2	121107420	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	4609960	121107420	122091953	47	29945											
LRP1B	53353	broad.mit.edu	37	chr2	141299381	141299381	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attggcaacagctatgattcCcattggctgatgtggaatat	11	13	10	7	0	0	2	0	2	0	0	1	3	1	3	1	3	2	3	1	3	4	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:141299381C>T	uc002tvj.1	-	44	8326	c.7354G>A	c.(7354-7356)GGA>AGA	p.G2452R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2452	Extracellular (Potential).|LDL-receptor class B 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCTATGATTCCCATTGGCTGA	0.378										TSP Lung(27;0.18)			15	57					0	0	0	0	T	141299381	T	T	141299381	3	4	164	1	0	0	0	0	1	0	0	0	9005	632	22	4	6637	4	LRP1B	2	141299381	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	20191961	141299381	101899992	48	29946											
KCNJ3	3760	broad.mit.edu	37	chr2	155555719	155555719	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgagacggaggccaccatCggctatggctaccgatacat	11	7	11	12	4	0	1	0	0	0	1	2	4	0	2	3	4	2	2	3	4	3	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:155555719C>A	uc002tyv.1	+	1	627	c.432C>A	c.(430-432)ATC>ATA	p.I144I	KCNJ3_uc010zce.1_Silent_p.I144I	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	144	Selectivity filter (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	AGGCCACCATCGGCTATGGCT	0.557													8	35					1.12685e-05	2.5921e-05	1	0	A	155555719	A	A	155555719	2	1	164	1	0	0	0	0	0	0	0	1	8091	874	31	3		3	KCNJ3	2	155555719	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	14256338	155555719	87643654	49	29947											
ACVR1C	130399	broad.mit.edu	37	chr2	158406691	158406691	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacctttgttgtcagcagcaAtgaaaccaaggatgttttca	12	13	8	8	0	2	1	2	1	0	0	2	2	2	2	2	1	4	4	2	1	4	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:158406691A>G	uc002tzk.3	-	4	1001	c.758T>C	c.(757-759)ATT>ACT	p.I253T	ACVR1C_uc002tzl.3_Missense_Mutation_p.I173T|ACVR1C_uc010fof.2_Intron|ACVR1C_uc010foe.2_Missense_Mutation_p.I203T	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	253	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						GTCAGCAGCAATGAAACCAAG	0.388													18	34					0	0	0	0	G	158406691	G	G	158406691	3	3	164	1	0	0	0	0	1	0	0	0	222	101	4	5	747	5	ACVR1C	2	158406691	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	2850972	158406691	84792682	50	29948											
SLC38A11	151258	broad.mit.edu	37	chr2	165768172	165768172	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtcacaaagcattccatagGgtatgtcaaaatgacagtga	15	10	9	7	0	2	2	2	2	0	0	3	2	3	2	1	1	1	2	1	1	5	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:165768172G>T	uc002ucv.1	-	11	1306	c.769C>A	c.(769-771)CCT>ACT	p.P257T	SLC38A11_uc002ucu.1_Missense_Mutation_p.P235T|SLC38A11_uc002ucw.1_Missense_Mutation_p.P257T	NM_173512	NP_775783	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	257	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						CATTCCATAGGGTATGTCAAA	0.378													4	20					0.00024832	0.000537325	1	0	T	165768172	T	T	165768172	3	4	164	1	0	0	0	0	1	0	0	0	14667	1232	43	4	463	4	SLC38A11	2	165768172	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	7361481	165768172	77431201	51	29949											
TTN	7273	broad.mit.edu	37	chr2	179613245	179613245	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccttggaactccagagctgGatctcctatatgagaataca	12	10	8	11	0	1	2	0	1	1	2	3	5	2	4	3	2	3	1	3	2	5	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:179613245G>T	uc002unb.2	-	46	14106	c.13882C>A	c.(13882-13884)CCA>ACA	p.P4628T	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAGAGCTGGATCTCCTATA	0.378													21	71					8.04996e-18	2.33571e-17	1	0	T	179613245	T	T	179613245	3	4	164	1	0	0	0	0	1	0	0	0	16803	1174	41	2	96415	2	TTN	2	179613245	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	13845073	179613245	63586128	52	29950											
TTN	7273	broad.mit.edu	37	chr2	179633515	179633515	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgtgagctttttggttctCatctggcacttgtcagttga	5	18	11	7	0	3	2	2	2	2	0	4	2	3	2	0	2	1	4	0	2	0	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:179633515C>T	uc010zfg.1	-	38	9272	c.9048G>A	c.(9046-9048)ATG>ATA	p.M3016I	TTN_uc010zfh.1_Missense_Mutation_p.M2970I|TTN_uc010zfi.1_Missense_Mutation_p.M2970I|TTN_uc010zfj.1_Missense_Mutation_p.M2970I|TTN_uc002unb.2_Missense_Mutation_p.M3016I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3016							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTGGTTCTCATCTGGCACT	0.418													15	35					0	0	0	0	T	179633515	T	T	179633515	3	4	164	1	0	0	0	0	1	0	0	0	16803	826	29	2	102240	2	TTN	2	179633515	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	20270	179633515	63565858	53	29951											
COL5A2	1290	broad.mit.edu	37	chr2	189907465	189907465	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttgggccaaatggtccaGggattccagcacttccttgt	7	12	10	12	0	1	0	0	0	1	0	4	1	4	1	4	3	1	1	4	3	1	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:189907465G>A	uc002uqk.2	-	49	3781	c.3506C>T	c.(3505-3507)CCT>CTT	p.P1169L	COL5A2_uc010frx.2_Missense_Mutation_p.P745L	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1169					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AAATGGTCCAGGGATTCCAGC	0.373													4	10					0	0	0	0	A	189907465	A	A	189907465	3	1	164	1	0	0	0	0	1	0	0	0	3712	1000	35	4	1017	4	COL5A2	2	189907465	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	10273950	189907465	53291908	54	29952											
STAT4	6775	broad.mit.edu	37	chr2	191940969	191940969	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttacctggacaggcatgttgGctgcagccaatattctcctc	8	12	9	12	0	1	0	0	0	1	0	3	1	1	1	3	3	3	4	3	3	3	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:191940969G>T	uc002usm.1	-	4	610	c.356C>A	c.(355-357)GCC>GAC	p.A119D	STAT4_uc002usn.1_Missense_Mutation_p.A119D|STAT4_uc002uso.2_Missense_Mutation_p.A119D|STAT4_uc002usp.3_Missense_Mutation_p.A119D	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	119					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			AGGCATGTTGGCTGCAGCCAA	0.284													11	59					1.08611e-07	2.67511e-07	1	0	T	191940969	T	T	191940969	3	4	164	1	0	0	0	0	1	0	0	0	15333	1203	42	4	1974	4	STAT4	2	191940969	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2033504	191940969	51258404	55	29953											
STK17B	9262	broad.mit.edu	37	chr2	197021180	197021180	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactattccaatatcaaaatGatttcacttgtattttcata	14	18	2	7	0	3	1	3	1	0	0	4	1	4	1	1	0	1	1	1	0	8	10			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:197021180G>C	uc002utk.2	-	3	642	c.318C>G	c.(316-318)ATC>ATG	p.I106M	STK17B_uc010fsh.2_Missense_Mutation_p.I106M	NM_004226	NP_004217	O94768	ST17B_HUMAN	serine/threonine kinase 17B	106	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			lung(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.141)			ATATCAAAATGATTTCACTTG	0.313													6	11					0	0	0	0	C	197021180	C	C	197021180	3	2	164	1	0	0	0	0	1	0	0	0	15357	1280	45	2	824	2	STK17B	2	197021180	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	5080211	197021180	46178193	56	29954											
SMARCAL1	50485	broad.mit.edu	37	chr2	217279531	217279531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attggcagaacagcatcagaGgactagctcgggcacctcca	12	6	11	12	1	1	2	1	0	0	2	3	3	2	3	2	3	3	4	2	3	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:217279531G>A	uc002vgc.3	+	3	434	c.104G>A	c.(103-105)AGG>AAG	p.R35K	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.R35K|SMARCAL1_uc010fvg.2_Missense_Mutation_p.R35K	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	35					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CAGCATCAGAGGACTAGCTCG	0.522									Schimke_Immuno-Osseous_Dysplasia				30	94					0	0	0	0	A	217279531	A	A	217279531	3	1	164	1	0	0	0	0	1	0	0	0	14837	1000	35	4	106	4	SMARCAL1	2	217279531	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	20258351	217279531	25919842	57	29955											
SLC11A1	6556	broad.mit.edu	37	chr2	219257742	219257743	+	Frame_Shift_Ins	INS	-	CT	CT																															ggtcacgcttcgcccgtgtcINSctcctcacccgctcctgcgc																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:219257742_219257743insCT	uc002vhv.2	+	12	1543_1544	c.1203_1204insCT	c.(1201-1206)GTCCTCfs	p.V401fs	SLC11A1_uc010fvp.1_3'UTR|SLC11A1_uc010fvq.1_3'UTR|SLC11A1_uc010zkc.1_Frame_Shift_Ins_p.V334fs|SLC11A1_uc002vhu.1_Frame_Shift_Ins_p.V196fs|SLC11A1_uc002vhw.2_Frame_Shift_Ins_p.V283fs|SLC11A1_uc010fvr.2_Frame_Shift_Ins_p.V196fs	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	401_402	Helical; (Potential).				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCGCCCGTGTCCTCCTCACCCG	0.634													---	---	---								CT	219257743	CT	CT	219257742	7	5	164	1	0	1	1	0	0	0	0	0	14445	842	30	0	1249	0	SLC11A1	2	219257742	Frame_Shift_Ins	INS	-	TCGA-CR-7399-01A-11D-2012-08	1978211	219257742	23941631	58	29956											
COL4A4	1286	broad.mit.edu	37	chr2	227924220	227924220	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcccaggtgaccaaatgcagGgtctcccgggattcctttct	7	11	10	13	1	2	1	0	1	2	0	5	2	4	2	4	3	1	1	4	3	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:227924220G>T	uc010zlt.1	-	28	2938	c.2284C>A	c.(2284-2286)CCT>ACT	p.P762T		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	762	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCAAATGCAGGGTCTCCCGGG	0.612													24	70					2.89027e-11	7.79558e-11	1	0	T	227924220	T	T	227924220	3	4	164	1	0	0	0	0	1	0	0	0	3708	1232	43	4	2872	4	COL4A4	2	227924220	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	8666478	227924220	15275153	59	29957											
DIS3L2	129563	broad.mit.edu	37	chr2	233194619	233194619	+	Frame_Shift_Del	DEL	G	-	-																															ctgctgcgccggcaccccccGccccaaacaaggatgctcag																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr2:233194619delG	uc010fxz.2	+	15	2112	c.1836delG	c.(1834-1836)CCGfs	p.P612fs	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	612							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		GGCACCCCCCGCCCCAAACAA	0.652													---	---	---								-	233194619	-	-	233194619	7	5	164	1	0	1	0	1	0	0	0	0	4559	1074	38	0	1890	0	DIS3L2	2	233194619	Frame_Shift_Del	DEL	G	TCGA-CR-7399-01A-11D-2012-08	5270399	233194619	10004754	60	29958											
CNTN6	27255	broad.mit.edu	37	chr3	1269678	1269678	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaaagctccaatttgcatGtgagtttggggtaaattttg	10	14	12	5	0	0	1	0	1	0	0	1	1	1	1	1	3	2	5	1	3	4	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:1269678G>T	uc003boz.2	+	4	625	c.358_splice	c.e4+1	p.Y120_splice	CNTN6_uc010hbo.2_Splice_Site_p.Y115_splice|CNTN6_uc011asj.1_Splice_Site_p.Y48_splice|CNTN6_uc003bpa.2_Splice_Site_p.Y120_splice	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor						axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CAATTTGCATGTGAGTTTGGG	0.383													28	95					7.63215e-27	2.31076e-26	1	0	T	1269678	T	T	1269678	5	4	164	1	0	0	0	0	0	0	1	0	3660	1391	48	4	369	4	CNTN6	3	1269678	Splice_Site	SNP	G	TCGA-CR-7399-01A-11D-2012-08		1269678	196752752	61	29959											
LRRN1	57633	broad.mit.edu	37	chr3	3888298	3888298	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttgccaaaagatttaagaGaaaaaactaccaccactcat	18	9	4	10	0	1	2	1	0	0	2	1	3	1	2	3	0	3	0	3	0	7	4	rs75344244		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:3888298G>A	uc003bpt.3	+	2	2734	c.1973G>A	c.(1972-1974)AGA>AAA	p.R658K	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	658	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		AGATTTAAGAGAAAAAACTAC	0.423													19	60					0	0	0	0	A	3888298	A	A	3888298	3	1	164	1	0	0	0	0	1	0	0	0	9084	942	33	2	1975	2	LRRN1	3	3888298	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2618620	3888298	194134132	62	29960											
ARPC4	10093	broad.mit.edu	37	chr3	9841894	9841894	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcaaagagctcctgttacaaCctgtgaccatcagcaggaat	13	8	9	11	0	1	2	1	1	0	1	2	3	2	3	3	1	4	4	3	1	4	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:9841894C>T	uc003bsz.1	+	3	727	c.148C>T	c.(148-150)CCT>TCT	p.P50S	ARPC4_uc003bta.1_5'UTR|ARPC4_uc003btb.1_5'UTR|ARPC4_uc003btc.1_5'UTR|TTLL3_uc003btd.3_5'UTR	NM_005718	NP_005709	P59998	ARPC4_HUMAN	actin related protein 2/3 complex subunit 4	50					actin filament polymerization|actin nucleation	Arp2/3 protein complex|cell projection|cytoplasm	actin binding				0	Medulloblastoma(99;0.227)					CCTGTTACAACCTGTGACCAT	0.478													11	44					0	0	0	0	T	9841894	T	T	9841894	3	4	164	1	0	0	0	0	1	0	0	0	975	507	18	4	158	4	ARPC4	3	9841894	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	5953596	9841894	188180536	63	29961											
STAC	6769	broad.mit.edu	37	chr3	36570191	36570191	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcattcttcattttaggccAggagacataattactctttt	10	18	5	8	0	4	1	2	0	2	1	4	2	4	1	1	2	1	0	1	2	3	9			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:36570191A>T	uc003cgh.1	+	9	963	c.924A>T	c.(922-924)CCA>CCT	p.P308P	STAC_uc011aya.1_Silent_p.P247P	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	308	SH3.				intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						ATTTTAGGCCAGGAGACATAA	0.294													5	14					0	0	0	0	T	36570191	T	T	36570191	2	4	164	1	0	0	0	0	0	0	0	1	15305	175	7	5		5	STAC	3	36570191	Silent	SNP	A	TCGA-CR-7399-01A-11D-2012-08	26728297	36570191	161452239	64	29962											
XIRP1	165904	broad.mit.edu	37	chr3	39229057	39229057	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gttggggcttgaacatccagGtgcaggactgtgcctcagcc	7	9	14	11	0	1	1	1	1	0	0	2	2	2	2	3	4	4	3	3	4	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:39229057G>T	uc003cjk.1	-	2	2101	c.1880C>A	c.(1879-1881)ACC>AAC	p.T627N	XIRP1_uc003cji.2_Missense_Mutation_p.T627N|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	627	Interaction with CTNNB1 (By similarity).|Xin 14.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GAACATCCAGGTGCAGGACTG	0.597													24	49					2.89027e-11	7.79558e-11	1	0	T	39229057	T	T	39229057	3	4	164	1	0	0	0	0	1	0	0	0	17497	1261	44	4	3655	4	XIRP1	3	39229057	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2658866	39229057	158793373	65	29963											
ULK4	54986	broad.mit.edu	37	chr3	41497085	41497085	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctcctgagccagacttctggGcctggaacagagagaagaga	12	6	13	10	0	1	5	0	1	1	4	2	8	2	6	3	2	2	0	3	2	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:41497085G>A	uc003ckv.3	-	34	3596	c.3395C>T	c.(3394-3396)GCC>GTC	p.A1132V		NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	1132							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AGACTTCTGGGCCTGGAACAG	0.542													20	30					0	0	0	0	A	41497085	A	A	41497085	3	1	164	1	0	0	0	0	1	0	0	0	17046	1217	42	4	448	4	ULK4	3	41497085	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2268028	41497085	156525345	66	29964											
ZNF502	91392	broad.mit.edu	37	chr3	44762622	44762622	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttagtcaaggatataattttGagaaaagcttgcttttgacc	13	15	8	5	0	1	2	1	2	0	1	1	4	1	3	1	1	2	2	1	1	6	8			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:44762622G>A	uc011baa.1	+	4	568	c.313G>A	c.(313-315)GAG>AAG	p.E105K	ZNF502_uc003cns.2_Missense_Mutation_p.E105K|ZNF502_uc011bab.1_Missense_Mutation_p.E105K|ZNF502_uc003cnt.2_Missense_Mutation_p.E105K	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		ATATAATTTTGAGAAAAGCTT	0.398													9	41					0	0	0	0	A	44762622	A	A	44762622	3	1	164	1	0	0	0	0	1	0	0	0	18017	1291	45	2	319	2	ZNF502	3	44762622	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3265537	44762622	153259808	67	29965											
RTP3	83597	broad.mit.edu	37	chr3	46542079	46542079	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagaaatgctatagaggaaGatttcagttgatagaggagg	16	9	14	2	0	1	5	1	1	0	4	1	8	1	7	0	3	1	2	0	3	6	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:46542079G>A	uc003cps.1	+	2	457	c.389G>A	c.(388-390)AGA>AAA	p.R130K		NM_031440	NP_113628	Q9BQQ7	RTP3_HUMAN	transmembrane protein 7	130	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		TATAGAGGAAGATTTCAGTTG	0.463													13	93					0	0	0	0	A	46542079	A	A	46542079	3	1	164	1	0	0	0	0	1	0	0	0	13800	942	33	2	395	2	RTP3	3	46542079	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1779457	46542079	151480351	68	29966											
CACNA1D	776	broad.mit.edu	37	chr3	53796040	53796040	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggggtattttagtgacGcctggaacacgtttgactcc	8	12	11	10	2	0	2	0	2	0	0	2	3	2	3	3	3	1	2	3	3	3	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:53796040G>T	uc003dgv.3	+	30	3965	c.3802G>T	c.(3802-3804)GCC>TCC	p.A1268S	CACNA1D_uc003dgu.3_Missense_Mutation_p.A1288S|CACNA1D_uc003dgy.3_Missense_Mutation_p.A1268S|CACNA1D_uc003dgw.3_Intron|CACNA1D_uc003dgx.1_Missense_Mutation_p.A416S	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1268	IV.|Helical; Name=S3 of repeat IV; (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TTTTAGTGACGCCTGGAACAC	0.562													20	54					3.62473e-10	9.67437e-10	1	0	T	53796040	T	T	53796040	3	4	164	1	0	0	0	0	1	0	0	0	2553	1087	38	3	4092	3	CACNA1D	3	53796040	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	7253961	53796040	144226390	69	29967											
CADM2	253559	broad.mit.edu	37	chr3	85932571	85932571	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatgcctgtcaaaacttcCaaggcatatctcaccgttct	12	11	5	13	1	3	0	2	0	2	0	5	0	4	0	3	1	2	2	3	1	5	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:85932571C>G	uc003dqj.2	+	3	968	c.342C>G	c.(340-342)TCC>TCG	p.S114S	CADM2_uc003dqk.2_Silent_p.S123S|CADM2_uc003dql.2_Silent_p.S116S	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	114	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TCAAAACTTCCAAGGCATATC	0.398													3	17					0	0	0	0	G	85932571	G	G	85932571	2	3	164	1	0	0	0	0	0	0	0	1	2579	581	21	4		4	CADM2	3	85932571	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	32136531	85932571	112089859	70	29968											
OR5AC2	81050	broad.mit.edu	37	chr3	97806802	97806802	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actctgatcttcatgtatgtGcgtcctgcatctggcttagc	6	15	9	11	1	4	1	1	1	3	0	5	1	5	1	1	1	3	3	1	1	2	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:97806802G>T	uc011bgs.1	+	1	786	c.786G>T	c.(784-786)GTG>GTT	p.V262V		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCATGTATGTGCGTCCTGCAT	0.428													15	57					2.23348e-06	5.3132e-06	1	0	T	97806802	T	T	97806802	2	4	164	1	0	0	0	0	0	0	0	1	11195	1306	46	4		4	OR5AC2	3	97806802	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	11874231	97806802	100215628	71	29969											
GPR128	84873	broad.mit.edu	37	chr3	100365491	100365491	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgaaggactgggacacatatGgctgtcaaaaagacaagggc	15	5	13	8	1	1	1	1	0	0	1	1	4	1	3	0	4	0	1	0	4	5	1	rs143826267	byFrequency	TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:100365491G>T	uc003duc.2	+	10	1457	c.1189G>T	c.(1189-1191)GGC>TGC	p.G397C	GPR128_uc011bhc.1_Missense_Mutation_p.G98C	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	397	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						GGACACATATGGCTGTCAAAA	0.393													6	40					1.06961e-07	2.64298e-07	1	0	T	100365491	T	T	100365491	3	4	164	1	0	0	0	0	1	0	0	0	6679	1348	47	4	1227	4	GPR128	3	100365491	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2558689	100365491	97656939	72	29970											
DZIP3	9666	broad.mit.edu	37	chr3	108373010	108373010	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcccatatgtggtagaaaaGgaagagcagttgaggaaaga	17	6	14	4	0	0	4	0	1	0	3	0	6	0	6	1	3	2	3	1	3	6	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:108373010G>T	uc003dxd.2	+	19	2474	c.2052G>T	c.(2050-2052)AAG>AAT	p.K684N	DZIP3_uc003dxf.1_Missense_Mutation_p.K684N|DZIP3_uc011bhm.1_Missense_Mutation_p.K135N|DZIP3_uc003dxg.1_Missense_Mutation_p.K407N	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	684					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TGGTAGAAAAGGAAGAGCAGT	0.363													21	25					2.70639e-06	6.39845e-06	1	0	T	108373010	T	T	108373010	3	4	164	1	0	0	0	0	1	0	0	0	4887	991	35	4	2122	4	DZIP3	3	108373010	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	8007519	108373010	89649420	73	29971											
CCDC52	152185	broad.mit.edu	37	chr3	113172677	113172677	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagacgattctcttcacttGaattctgaatgtctgtatca	11	15	7	8	1	5	3	2	2	3	1	6	5	5	3	0	0	0	1	0	0	3	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:113172677G>C	uc003eag.3	-	14	2069	c.1778C>G	c.(1777-1779)TCA>TGA	p.S593*	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Nonsense_Mutation_p.S489*	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	593					cell division|mitosis	centriole|spindle	protein binding				0						CTCTTCACTTGAATTCTGAAT	0.428													41	32					0	0	0	0	C	113172677	C	C	113172677	4	2	164	1	0	0	0	0	0	1	0	0	2835	1294	45	2	809	2	CCDC52	3	113172677	Nonsense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	4799667	113172677	84849753	74	29972											
PTPLB	201562	broad.mit.edu	37	chr3	123247241	123247241	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaacacttacctctttgaCgctatgtgttactgcccata	11	14	5	11	1	1	1	0	1	1	0	1	1	1	1	2	0	4	2	2	0	6	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:123247241C>A	uc003egj.2	-	4	423	c.373G>T	c.(373-375)GTC>TTC	p.V125F		NM_198402	NP_940684	Q6Y1H2	HACD2_HUMAN	protein tyrosine phosphatase-like (proline	125	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	lyase activity|protein binding			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.1)		ACCTCTTTGACGCTATGTGTT	0.358													18	37					1.67942e-08	4.21781e-08	1	0	A	123247241	A	A	123247241	3	1	164	1	0	0	0	0	1	0	0	0	12840	536	19	3	407	3	PTPLB	3	123247241	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	10074564	123247241	74775189	75	29973											
PLXNA1	5361	broad.mit.edu	37	chr3	126707921	126707921	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaggagcactacctgtccaGcgtgcaggaggcaggcagca	11	5	14	11	1	0	0	0	0	0	0	1	2	1	2	2	4	5	5	2	4	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:126707921G>A	uc003ejg.2	+	1	420	c.416G>A	c.(415-417)AGC>AAC	p.S139N		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	162	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		TACCTGTCCAGCGTGCAGGAG	0.657													4	32					0	0	0	0	A	126707921	A	A	126707921	3	1	164	1	0	0	0	0	1	0	0	0	12174	971	34	4	487	4	PLXNA1	3	126707921	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3460680	126707921	71314509	76	29974											
PIK3R4	30849	broad.mit.edu	37	chr3	130403120	130403120	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacccaggactgatacagaGggtgcattgagaggcgtctg	10	8	14	9	1	2	3	1	2	1	2	2	5	2	4	1	3	2	1	1	3	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:130403120G>A	uc003enj.2	-	16	4162	c.3581C>T	c.(3580-3582)CCT>CTT	p.P1194L		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	1194	WD 5.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						CTGATACAGAGGGTGCATTGA	0.483													8	57					0	0	0	0	A	130403120	A	A	130403120	3	1	164	1	0	0	0	0	1	0	0	0	11976	1000	35	4	515	4	PIK3R4	3	130403120	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3695199	130403120	67619310	77	29975											
EPHB1	2047	broad.mit.edu	37	chr3	134670706	134670706	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgcaaaattttgcagtgtTtccagagactatgacagggg	11	12	12	6	0	0	2	0	1	0	1	1	3	1	2	1	2	2	3	1	2	3	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:134670706T>C	uc003eqt.2	+	3	837	c.617T>C	c.(616-618)TTT>TCT	p.F206S	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Intron	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	206	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TTTGCAGTGTTTCCAGAGACT	0.483													40	244					0	0	0	0	C	134670706	C	C	134670706	3	2	164	1	0	0	0	0	1	0	0	0	5198	1841	64	5	627	5	EPHB1	3	134670706	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	4267586	134670706	63351724	78	29976											
TMEM22	80723	broad.mit.edu	37	chr3	136573436	136573436	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaagaaatcaatgaaggctAtggaaattttatggaggaaa	18	10	11	2	0	1	3	1	2	0	1	1	6	1	6	0	4	0	1	0	4	8	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:136573436A>G	uc003erf.3	+	2	348	c.134A>G	c.(133-135)TAT>TGT	p.Y45C	TMEM22_uc003erg.3_Missense_Mutation_p.Y45C|TMEM22_uc010hub.2_Missense_Mutation_p.Y45C	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	45						Golgi apparatus|integral to membrane				ovary(1)	1						AATGAAGGCTATGGAAATTTT	0.398													44	275					0	0	0	0	G	136573436	G	G	136573436	3	3	164	1	0	0	0	0	1	0	0	0	16209	449	16	5	136	5	TMEM22	3	136573436	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	1902730	136573436	61448994	79	29977											
DZIP1L	199221	broad.mit.edu	37	chr3	137796423	137796423	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcttcagcaaagtggggttaCgcctcagagctgccagcacc	9	7	12	13	1	2	1	2	0	0	1	2	1	2	1	3	2	5	5	3	2	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:137796423C>T	uc003erq.2	-	11	1703	c.1340G>A	c.(1339-1341)CGT>CAT	p.R447H	DZIP1L_uc003err.1_Missense_Mutation_p.R447H	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	447						intracellular	zinc ion binding	p.R447P(1)		ovary(1)|pancreas(1)	2						AGTGGGGTTACGCCTCAGAGC	0.547													28	162					0	0	0	0	T	137796423	T	T	137796423	3	4	164	1	0	0	0	0	1	0	0	0	4886	536	19	1	996	1	DZIP1L	3	137796423	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1222987	137796423	60226007	80	29978											
C3orf72	401089	broad.mit.edu	37	chr3	138669186	138669186	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctactagggaagcgtcgCggctgctctgaggcaggcag	7	7	16	11	3	2	1	0	1	2	0	3	2	2	2	0	4	3	5	0	4	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:138669186C>A	uc003esx.1	+	3	431	c.300C>A	c.(298-300)CGC>CGA	p.R100R	C3orf72_uc011bmr.1_3'UTR	NM_001040061	NP_001035150	Q6ZUU3	CC072_HUMAN	chromosome 3 open reading frame 72	100											0						GGAAGCGTCGCGGCTGCTCTG	0.687													22	42					2.89027e-11	7.79558e-11	1	0	A	138669186	A	A	138669186	2	1	164	1	0	0	0	0	0	0	0	1	2254	755	27	3		3	C3orf72	3	138669186	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	872763	138669186	59353244	81	29979											
C3orf58	205428	broad.mit.edu	37	chr3	143691744	143691744	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggagaccaaggactcgggCagcttcctgcttcgcaacct	8	7	12	14	3	0	1	0	0	0	1	3	3	1	2	3	3	3	4	3	3	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:143691744C>T	uc003evo.2	+	1	1105	c.570C>T	c.(568-570)GGC>GGT	p.G190G	C3orf58_uc011bnl.1_5'Flank	NM_173552	NP_775823	Q8NDZ4	CC058_HUMAN	hypothetical protein LOC205428 isoform a	190						COPI vesicle coat|extracellular region				ovary(1)	1						AGGACTCGGGCAGCTTCCTGC	0.697													7	13					0	0	0	0	T	143691744	T	T	143691744	2	4	164	1	0	0	0	0	0	0	0	1	2246	697	25	4		4	C3orf58	3	143691744	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	5022558	143691744	54330686	82	29980											
ZIC1	7545	broad.mit.edu	37	chr3	147128596	147128596	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctgcaagtggatcgagcccGagcagctggccaaccccaaa	11	5	11	14	2	1	0	0	0	1	0	2	3	1	1	4	2	5	3	4	2	3	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:147128596G>A	uc003ewe.2	+	1	1416	c.697G>A	c.(697-699)GAG>AAG	p.E233K		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	233	C2H2-type 1; atypical.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GATCGAGCCCGAGCAGCTGGC	0.592													9	48					0	0	0	0	A	147128596	A	A	147128596	3	1	164	1	0	0	0	0	1	0	0	0	17745	1059	37	1	699	1	ZIC1	3	147128596	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3436852	147128596	50893834	83	29981											
SI	6476	broad.mit.edu	37	chr3	164732915	164732915	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatcgatttagtacctttGcccaacaaatgtcattggtg	11	14	8	8	1	1	0	1	0	0	0	2	2	1	0	2	1	3	1	2	1	5	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:164732915G>T	uc003fei.2	-	33	4057	c.3995C>A	c.(3994-3996)GCA>GAA	p.A1332E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1332	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAGTACCTTTGCCCAACAAAT	0.323										HNSCC(35;0.089)			5	51					0.000602214	0.0012673	1	0	T	164732915	T	T	164732915	3	4	164	1	0	0	0	0	1	0	0	0	14362	1319	46	4	1552	4	SI	3	164732915	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	17604319	164732915	33289515	84	29982											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			17	44					0	0	0	0	A	178936091	A	A	178936091	3	1	164	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	14203176	178936091	19086339	85	29983											
VPS8	23355	broad.mit.edu	37	chr3	184711810	184711810	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaaaacttggagaaatccagGgacttatcttgggaatgtta	14	11	11	5	0	1	1	0	0	1	1	2	5	2	3	1	3	1	1	1	3	6	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:184711810G>A	uc003fpb.1	+	42	3790	c.3619G>A	c.(3619-3621)GGA>AGA	p.G1207R	VPS8_uc010hyd.1_Missense_Mutation_p.G1117R|VPS8_uc010hye.1_Missense_Mutation_p.G636R	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1209							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			AGAAATCCAGGGACTTATCTT	0.294													3	7					0	0	0	0	A	184711810	A	A	184711810	3	1	164	1	0	0	0	0	1	0	0	0	17286	1233	43	4	3787	4	VPS8	3	184711810	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	5775719	184711810	13310620	86	29984											
MASP1	5648	broad.mit.edu	37	chr3	186974553	186974553	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accctcctccagctcgatggTatacaggcattcagagctct	9	10	8	14	1	2	1	1	0	1	1	5	2	4	1	3	2	3	4	3	2	2	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:186974553T>C	uc003frh.1	-	5	975	c.643A>G	c.(643-645)ACC>GCC	p.T215A	MASP1_uc003fri.2_Missense_Mutation_p.T215A|MASP1_uc003frj.2_Missense_Mutation_p.T184A|MASP1_uc003frk.1_Missense_Mutation_p.T215A|MASP1_uc011bse.1_Missense_Mutation_p.T189A	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	215	Interaction with FCN2.|CUB 2.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		AGCTCGATGGTATACAGGCAT	0.512													10	95					0	0	0	0	C	186974553	C	C	186974553	3	2	164	1	0	0	0	0	1	0	0	0	9375	1638	57	5	2449	5	MASP1	3	186974553	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	2262743	186974553	11047877	87	29985											
FGF12	2257	broad.mit.edu	37	chr3	192078262	192078262	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccatcaatggtaccatctgGgtgcatctgcaggaagtatc	10	10	10	11	0	3	0	1	0	2	0	4	1	3	1	2	3	3	4	2	3	4	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr3:192078262G>T	uc003fsx.2	-	2	1091	c.265C>A	c.(265-267)CCA>ACA	p.P89T	FGF12_uc003fsy.2_Missense_Mutation_p.P27T	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	89					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		GTACCATCTGGGTGCATCTGC	0.408													22	68					4.26978e-12	1.17228e-11	1	0	T	192078262	T	T	192078262	3	4	164	1	0	0	0	0	1	0	0	0	5873	1232	43	4	482	4	FGF12	3	192078262	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	5103709	192078262	5944168	88	29986											
GBA3	57733	broad.mit.edu	37	chr4	22749401	22749401	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atctggatttatttgctaaaCccatattcatcgatggtgat	11	16	7	7	1	2	1	1	1	1	0	3	3	2	2	1	2	2	1	1	2	4	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:22749401C>A	uc003gqp.3	+	3	860	c.769C>A	c.(769-771)CCC>ACC	p.P257T	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.P258T	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	257					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						ATTTGCTAAACCCATATTCAT	0.448													18	68					3.52763e-06	8.2635e-06	1	0	A	22749401	A	A	22749401	3	1	164	1	0	0	0	0	1	0	0	0	6303	507	18	4	779	4	GBA3	4	22749401	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08		22749401	168404875	89	29987											
N4BP2	55728	broad.mit.edu	37	chr4	40115063	40115063	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtatgtagtctcagaaacaCaaatataaagtcctttttcg	14	14	6	7	1	1	1	1	0	1	1	4	1	2	1	1	0	1	2	1	0	7	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:40115063C>A	uc003guy.3	+	7	1937	c.1599C>A	c.(1597-1599)CAC>CAA	p.H533Q	N4BP2_uc010ifq.2_Missense_Mutation_p.H453Q|N4BP2_uc010ifr.2_Missense_Mutation_p.H453Q	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	533						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						CTCAGAAACACAAATATAAAG	0.313													25	97					0.000375601	0.000805911	1	0	A	40115063	A	A	40115063	3	1	164	1	0	0	0	0	1	0	0	0	10163	477	17	4	1617	4	N4BP2	4	40115063	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	17365662	40115063	151039213	90	29988											
GUF1	60558	broad.mit.edu	37	chr4	44680736	44680736	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccccggggccccggtccGcgccgacccttggggctgct	1	6	16	18	5	0	0	0	0	0	0	1	1	1	0	7	6	1	2	7	6	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:44680736G>A	uc003gww.3	+	1	304	c.97G>A	c.(97-99)GCG>ACG	p.A33T	GUF1_uc010ifz.1_RNA	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	33					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						GCCCCGGTCCGCGCCGACCCT	0.692													5	24					0	0	0	0	A	44680736	A	A	44680736	3	1	164	1	0	0	0	0	1	0	0	0	6938	1087	38	1	99	1	GUF1	4	44680736	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	4565673	44680736	146473540	91	29989											
GABRA2	2555	broad.mit.edu	37	chr4	46314582	46314582	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggcattgtcatattatgaGctactgattttttcccattg	8	19	7	7	0	1	2	1	2	0	0	2	2	2	2	1	1	2	2	1	1	3	9			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:46314582G>A	uc003gxc.3	-	4	1080	c.407C>T	c.(406-408)GCT>GTT	p.A136V	GABRA2_uc010igc.2_Missense_Mutation_p.A136V|GABRA2_uc011bzc.1_Missense_Mutation_p.A81V|GABRA2_uc003gxe.2_Missense_Mutation_p.A136V	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	136	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CATATTATGAGCTACTGATTT	0.343													11	69					0	0	0	0	A	46314582	A	A	46314582	3	1	164	1	0	0	0	0	1	0	0	0	6195	971	34	4	972	4	GABRA2	4	46314582	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1633846	46314582	144839694	92	29990											
NFXL1	152518	broad.mit.edu	37	chr4	47857090	47857090	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttaccttttttattctttTacaaggacatctaagtttta	11	21	3	6	0	2	0	0	0	2	0	2	1	2	1	1	1	2	1	1	1	6	11			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:47857090T>A	uc010igh.2	-	20	2584	c.2407A>T	c.(2407-2409)AAA>TAA	p.K803*	NFXL1_uc003gxo.2_Nonsense_Mutation_p.K128*|NFXL1_uc003gxp.2_Nonsense_Mutation_p.K803*|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Nonsense_Mutation_p.K803*	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	803						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TTTATTCTTTTACAAGGACAT	0.234													15	51					0	0	0	0	A	47857090	A	A	47857090	4	1	164	1	0	0	0	0	0	1	0	0	10442	1763	61	5	344	5	NFXL1	4	47857090	Nonsense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	1542508	47857090	143297186	93	29991											
USP46	64854	broad.mit.edu	37	chr4	53492412	53492412	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcatgtagttatcaaagaGatctggaaaggagaaggtgg	14	9	14	4	0	2	2	1	0	1	2	2	5	2	3	0	4	1	3	0	4	5	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:53492412G>C	uc003gzn.2	-	4	519	c.334C>G	c.(334-336)CTC>GTC	p.L112V	USP46_uc003gzm.3_Missense_Mutation_p.L105V|USP46_uc011bzr.1_Missense_Mutation_p.L89V|USP46_uc011bzs.1_Translation_Start_Site	NM_022832	NP_073743	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46 isoform 1	112					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0295)			TTATCAAAGAGATCTGGAAAG	0.333													6	26					0	0	0	0	C	53492412	C	C	53492412	3	2	164	1	0	0	0	0	1	0	0	0	17145	942	33	2	790	2	USP46	4	53492412	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	5635322	53492412	137661864	94	29992											
ANKRD17	26057	broad.mit.edu	37	chr4	73956626	73956626	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactgaaattgggagcaataGgcttatttgctggatgtact	11	13	11	6	0	0	1	0	1	0	0	0	3	0	3	0	3	3	4	0	3	5	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:73956626G>A	uc003hgp.2	-	29	6836	c.6719C>T	c.(6718-6720)CCT>CTT	p.P2240L	ANKRD17_uc003hgo.2_Missense_Mutation_p.P2127L|ANKRD17_uc003hgq.2_Missense_Mutation_p.P1989L|ANKRD17_uc003hgr.2_Missense_Mutation_p.P2239L	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2240					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGGAGCAATAGGCTTATTTGC	0.458													49	224					0	0	0	0	A	73956626	A	A	73956626	3	1	164	1	0	0	0	0	1	0	0	0	646	1000	35	4	1116	4	ANKRD17	4	73956626	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	20464214	73956626	117197650	95	29993											
GPRIN3	285513	broad.mit.edu	37	chr4	90169444	90169444	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cccatgggatcagatggcagGctcaggctggtggctgtctt	6	10	15	10	0	3	1	2	0	1	1	3	2	3	2	1	6	0	4	1	6	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:90169444G>T	uc003hsm.1	-	2	2337	c.1818C>A	c.(1816-1818)AGC>AGA	p.S606R		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	606										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		CAGATGGCAGGCTCAGGCTGG	0.582													31	100					1.08312e-15	3.08427e-15	1	0	T	90169444	T	T	90169444	3	4	164	1	0	0	0	0	1	0	0	0	6770	1194	42	4	516	4	GPRIN3	4	90169444	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	16212818	90169444	100984832	96	29994											
GSTCD	79807	broad.mit.edu	37	chr4	106744222	106744222	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aattgtggatttctgcagcgGtggggtattttatctctcct	6	17	11	7	1	2	0	0	0	2	0	4	1	3	1	1	4	2	2	1	4	3	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:106744222G>A	uc003hxz.3	+	6	1424	c.1352G>A	c.(1351-1353)GGT>GAT	p.G451D	GSTCD_uc003hxx.2_Missense_Mutation_p.G451D|GSTCD_uc003hxy.3_Missense_Mutation_p.G364D|GSTCD_uc011cfb.1_Missense_Mutation_p.G74D	NM_001031720	NP_001026890	Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain	451						cytoplasm	rRNA methyltransferase activity			breast(1)|central_nervous_system(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)		TTCTGCAGCGGTGGGGTATTT	0.383													25	75					0	0	0	0	A	106744222	A	A	106744222	3	1	164	1	0	0	0	0	1	0	0	0	6874	1261	44	4	1370	4	GSTCD	4	106744222	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	16574778	106744222	84410054	97	29995											
ANK2	287	broad.mit.edu	37	chr4	114284553	114284553	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atcaaattcgaattgaaaatCccaactctcttcaagaccag	16	10	4	11	1	3	2	2	1	1	1	6	3	4	2	2	0	1	0	2	0	6	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:114284553C>A	uc003ibe.3	+	40	10916	c.10816C>A	c.(10816-10818)CCC>ACC	p.P3606T	ANK2_uc003ibd.3_Missense_Mutation_p.P1512T|ANK2_uc003ibf.3_Missense_Mutation_p.P1521T|ANK2_uc011cgc.1_Missense_Mutation_p.P697T|ANK2_uc003ibg.3_Missense_Mutation_p.P505T|ANK2_uc003ibh.3_Missense_Mutation_p.P195T|ANK2_uc011cgd.1_Missense_Mutation_p.P908T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3573	Death.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AATTGAAAATCCCAACTCTCT	0.383													11	42					1.58986e-06	3.81767e-06	1	0	A	114284553	A	A	114284553	3	1	164	1	0	0	0	0	1	0	0	0	621	855	30	2	11039	2	ANK2	4	114284553	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	7540331	114284553	76869723	98	29996											
ANP32C	23520	broad.mit.edu	37	chr4	165118530	165118530	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgaaaaggtctaagctctTgaggttttctaactgtttca	11	16	8	6	0	4	2	1	2	3	0	4	2	4	2	0	2	2	3	0	2	4	7	rs138319123		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:165118530T>A	uc011cjk.1	-	1	334	c.334A>T	c.(334-336)AAG>TAG	p.K112*	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	112	LRR 4.										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		TCTAAGCTCTTGAGGTTTTCT	0.418													34	92					0	0	0	0	A	165118530	A	A	165118530	4	1	164	1	0	0	0	0	0	1	0	0	707	1821	63	5	373	5	ANP32C	4	165118530	Nonsense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	50833977	165118530	26035746	99	29997											
WDR17	116966	broad.mit.edu	37	chr4	177098210	177098210	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccttttcacacgttcagtCagctattaaaacgtcgggag	10	13	8	10	3	3	0	3	0	0	0	5	1	4	1	1	1	2	2	1	1	3	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:177098210C>A	uc003iuj.2	+	29	3724	c.3568C>A	c.(3568-3570)CAG>AAG	p.Q1190K	WDR17_uc003iuk.2_Missense_Mutation_p.Q1166K|WDR17_uc003ium.3_Missense_Mutation_p.Q1151K|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.Q401K	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	1190										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CACGTTCAGTCAGCTATTAAA	0.348													8	29					5.4927e-09	1.40716e-08	1	0	A	177098210	A	A	177098210	3	1	164	1	0	0	0	0	1	0	0	0	17345	840	29	2	3678	2	WDR17	4	177098210	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	11979680	177098210	14056066	100	29998											
ENPP6	133121	broad.mit.edu	37	chr4	185018464	185018464	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcgtagccgtgccatccacGctgccaaccttcccgcctgc	5	8	9	19	4	0	0	0	0	0	0	3	0	2	0	7	0	5	2	7	0	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr4:185018464G>T	uc003iwc.2	-	7	1193	c.1051C>A	c.(1051-1053)CGT>AGT	p.R351S		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	351	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		TGCCATCCACGCTGCCAACCT	0.577													8	33					3.09899e-07	7.55994e-07	1	0	T	185018464	T	T	185018464	3	4	164	1	0	0	0	0	1	0	0	0	5158	1087	38	3	279	3	ENPP6	4	185018464	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	7920254	185018464	6135812	101	29999											
MARCH6	10299	broad.mit.edu	37	chr5	10415698	10415698	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctatgtttgctggctaaccAtaagggctgtgacggtgatg	8	13	13	7	1	1	2	0	2	1	0	1	2	1	2	1	3	2	4	1	3	3	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:10415698A>G	uc003jet.1	+	21	2248	c.2065A>G	c.(2065-2067)ATA>GTA	p.I689V	MARCH6_uc011cmu.1_Missense_Mutation_p.I641V|MARCH6_uc003jeu.1_Missense_Mutation_p.I387V|MARCH6_uc011cmv.1_Missense_Mutation_p.I584V	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	689	Helical; (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						CTGGCTAACCATAAGGGCTGT	0.493													35	95					0	0	0	0	G	10415698	G	G	10415698	3	3	164	1	0	0	0	0	1	0	0	0	9358	217	8	5	2147	5	MARCH6	5	10415698	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08		10415698	170499562	102	30000											
DNAH5	1767	broad.mit.edu	37	chr5	13719206	13719206	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agttctgcagaagtgcccatCctccctgtcaatagcagtaa	11	10	8	12	0	2	1	1	0	1	1	4	1	4	1	3	0	3	4	3	0	4	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:13719206C>T	uc003jfd.2	-	72	12326	c.12284G>A	c.(12283-12285)GGA>GAA	p.G4095E	DNAH5_uc003jfc.2_Missense_Mutation_p.G263E	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4095	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAGTGCCCATCCTCCCTGTCA	0.363									Kartagener_syndrome				10	33					0	0	0	0	T	13719206	T	T	13719206	3	4	164	1	0	0	0	0	1	0	0	0	4626	855	30	2	1622	2	DNAH5	5	13719206	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	3303508	13719206	167196054	103	30001											
CDH10	1008	broad.mit.edu	37	chr5	24511453	24511453	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctttttcacagtgatgaTgccttcctgtgtgtccttct	5	17	7	12	0	2	2	1	2	1	0	4	2	4	2	4	0	1	0	4	0	0	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:24511453T>G	uc003jgr.1	-	6	1317	c.985A>C	c.(985-987)ATC>CTC	p.I329L	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	329	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ACAGTGATGATGCCTTCCTGT	0.413										HNSCC(23;0.051)			17	148					0	0	0	0	G	24511453	G	G	24511453	3	3	164	1	0	0	0	0	1	0	0	0	3111	1464	51	5	1409	5	CDH10	5	24511453	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	10792247	24511453	156403807	104	30002											
NPR3	4883	broad.mit.edu	37	chr5	32774814	32774814	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atctggggttttcttttcagGttaacatgtttgttgaagga	8	18	11	4	0	3	1	1	1	2	0	3	2	3	2	0	4	1	4	0	4	2	7			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:32774814G>T	uc003jhv.2	+	4	1278	c.1060G>T	c.(1060-1062)GTT>TTT	p.V354F	NPR3_uc010iuo.2_Missense_Mutation_p.V138F|NPR3_uc011cnz.1_Missense_Mutation_p.V138F|NPR3_uc003jhu.2_Missense_Mutation_p.V354F	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	354	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	TTCTTTTCAGGTTAACATGTT	0.443													39	202					1.30998e-17	3.78659e-17	1	0	T	32774814	T	T	32774814	3	4	164	1	0	0	0	0	1	0	0	0	10650	1275	44	4	1074	4	NPR3	5	32774814	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	8263361	32774814	148140446	105	30003											
EGFLAM	133584	broad.mit.edu	37	chr5	38427226	38427226	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaatttgagatcacatttcgGccagactcaggagatggtgt	11	11	12	7	1	2	3	2	1	0	3	3	6	2	3	1	3	0	0	1	3	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:38427226G>T	uc003jlc.1	+	14	2250	c.1926G>T	c.(1924-1926)CGG>CGT	p.R642R	EGFLAM_uc003jlb.1_Silent_p.R642R|EGFLAM_uc003jle.1_Silent_p.R408R|EGFLAM_uc003jlf.1_Silent_p.R8R	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	642	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TCACATTTCGGCCAGACTCAG	0.527													30	169					2.4375e-19	7.15373e-19	1	0	T	38427226	T	T	38427226	2	4	164	1	0	0	0	0	0	0	0	1	4988	1190	42	4		4	EGFLAM	5	38427226	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	5652412	38427226	142488034	106	30004											
EGFLAM	133584	broad.mit.edu	37	chr5	38427334	38427334	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagttccgctttgactgtggCtctgggaccggtgtcctcag	4	12	14	11	2	2	1	1	1	1	0	4	3	4	2	3	3	0	3	3	3	0	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:38427334C>T	uc003jlc.1	+	14	2358	c.2034C>T	c.(2032-2034)GGC>GGT	p.G678G	EGFLAM_uc003jlb.1_Silent_p.G678G|EGFLAM_uc003jle.1_Silent_p.G444G|EGFLAM_uc003jlf.1_Silent_p.G44G	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	678	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TTGACTGTGGCTCTGGGACCG	0.507													27	230					0	0	0	0	T	38427334	T	T	38427334	2	4	164	1	0	0	0	0	0	0	0	1	4988	784	28	4		4	EGFLAM	5	38427334	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	108	38427334	142487926	107	30005											
SV2C	22987	broad.mit.edu	37	chr5	75428020	75428020	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccaagaatgcggtcatggtCgttttcagtgggcccttttc	6	14	11	10	2	2	1	2	0	0	1	5	1	3	1	2	3	1	1	2	3	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:75428020C>T	uc003kei.1	+	2	579	c.445C>T	c.(445-447)CGT>TGT	p.R149C		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	149	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CGGTCATGGTCGTTTTCAGTG	0.527													23	80					0	0	0	0	T	75428020	T	T	75428020	3	4	164	1	0	0	0	0	1	0	0	0	15485	884	31	1	447	1	SV2C	5	75428020	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	37000686	75428020	105487240	108	30006											
VCAN	1462	broad.mit.edu	37	chr5	82786136	82786136	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatcaagattggtcaggactAcaaagggagagtgtctgtgc	12	10	13	6	0	3	2	2	0	1	2	3	4	3	3	0	3	2	0	0	3	4	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:82786136A>T	uc003kii.3	+	3	646	c.290A>T	c.(289-291)TAC>TTC	p.Y97F	VCAN_uc003kij.3_Missense_Mutation_p.Y97F|VCAN_uc010jau.2_Missense_Mutation_p.Y97F|VCAN_uc003kik.3_Missense_Mutation_p.Y97F|VCAN_uc003kih.3_Missense_Mutation_p.Y97F	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	97	Ig-like V-type.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GGTCAGGACTACAAAGGGAGA	0.483													22	69					0	0	0	0	T	82786136	T	T	82786136	3	4	164	1	0	0	0	0	1	0	0	0	17206	391	14	5	296	5	VCAN	5	82786136	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	7358116	82786136	98129124	109	30007											
FTMT	94033	broad.mit.edu	37	chr5	121188322	121188322	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tagtgaagatgggggccccgGatgctggcctggcggagtac	7	7	18	9	2	0	2	0	1	0	1	0	4	0	4	3	6	2	2	3	6	3	2	rs138610881	byFrequency	TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:121188322G>T	uc003kss.2	+	1	673	c.664G>T	c.(664-666)GAT>TAT	p.D222Y		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	222					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GGGGGCCCCGGATGCTGGCCT	0.507													34	93					6.84511e-11	1.83977e-10	1	0	T	121188322	T	T	121188322	3	4	164	1	0	0	0	0	1	0	0	0	6119	1174	41	2	666	2	FTMT	5	121188322	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	38402186	121188322	59726938	110	30008											
ISOC1	51015	broad.mit.edu	37	chr5	128430682	128430682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgtggtgcagctgttcgccGaggagtggggccagtacgtg	5	9	18	9	4	0	0	0	0	0	0	2	2	0	1	2	4	3	4	2	4	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:128430682G>A	uc003kva.2	+	1	241	c.223G>A	c.(223-225)GAG>AAG	p.E75K		NM_016048	NP_057132	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	75						peroxisome	catalytic activity				0		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		GCTGTTCGCCGAGGAGTGGGG	0.652													5	16					0	0	0	0	A	128430682	A	A	128430682	3	1	164	1	0	0	0	0	1	0	0	0	7901	1059	37	1	225	1	ISOC1	5	128430682	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	7242360	128430682	52484578	111	30009											
PCDHB6	56130	broad.mit.edu	37	chr5	140530921	140530921	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaaaacttaccagagatCacagtggcagttttcagtgt	13	10	9	9	0	2	2	2	0	0	2	2	3	2	2	2	1	2	2	2	1	3	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:140530921C>A	uc003lir.2	+	1	1083	c.1083C>A	c.(1081-1083)ATC>ATA	p.I361I	PCDHB6_uc011dah.1_Silent_p.I225I	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	361	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TACCAGAGATCACAGTGGCAG	0.453													14	40					1.5842e-08	3.99177e-08	1	0	A	140530921	A	A	140530921	2	1	164	1	0	0	0	0	0	0	0	1	11600	816	29	2		2	PCDHB6	5	140530921	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	12100239	140530921	40384339	112	30010											
PCDHB8	56128	broad.mit.edu	37	chr5	140558046	140558046	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaaatgttggtgaaagtatCagagagcagtcctcctggga	13	9	12	7	0	1	2	1	1	0	1	3	4	3	3	2	2	1	3	2	2	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:140558046C>G	uc011dai.1	+	1	617	c.431C>G	c.(430-432)TCA>TGA	p.S144*	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	144	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGAAAGTATCAGAGAGCAGT	0.423													13	49					0	0	0	0	G	140558046	G	G	140558046	4	3	164	1	0	0	0	0	0	1	0	0	11602	838	29	2	433	2	PCDHB8	5	140558046	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	27125	140558046	40357214	113	30011											
PCDHGA2	56113	broad.mit.edu	37	chr5	140719785	140719785	+	Frame_Shift_Del	DEL	C	-	-																															ccttgacagggaacagttttCcttttacaacatcactctaa																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:140719785delC	uc003ljk.1	+	1	1432	c.1247delC	c.(1246-1248)TCCfs	p.S416fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Frame_Shift_Del_p.S416fs	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	416	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACAGTTTTCCTTTTACAAC	0.478													---	---	---								-	140719785	-	-	140719785	7	5	164	1	0	1	0	1	0	0	0	0	11608	855	30	0	1249	0	PCDHGA2	5	140719785	Frame_Shift_Del	DEL	C	TCGA-CR-7399-01A-11D-2012-08	161739	140719785	40195475	114	30012											
PCDHGB4	8641	broad.mit.edu	37	chr5	140768028	140768028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagatggcagtaaataccctGagatggtattgaagacacct	14	9	10	8	0	0	4	0	2	0	3	0	5	0	4	2	2	1	3	2	2	5	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:140768028G>A	uc003lkc.1	+	1	577	c.577G>A	c.(577-579)GAG>AAG	p.E193K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.E193K	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	193	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAAATACCCTGAGATGGTATT	0.443													16	55					0	0	0	0	A	140768028	A	A	140768028	3	1	164	1	0	0	0	0	1	0	0	0	11619	1291	45	2	579	2	PCDHGB4	5	140768028	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	48243	140768028	40147232	115	30013											
ARHGAP26	23092	broad.mit.edu	37	chr5	142292826	142292826	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacagactccattgagaaGaggttttgctttgatgtgga	13	12	11	5	0	0	4	0	2	0	3	1	6	1	5	1	2	2	2	1	2	3	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:142292826G>T	uc011dbj.1	+	10	1031	c.996G>T	c.(994-996)AAG>AAT	p.K332N	ARHGAP26_uc003lmt.2_Missense_Mutation_p.K332N|ARHGAP26_uc003lmw.2_Missense_Mutation_p.K332N	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	332	PH.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCATTGAGAAGAGGTTTTGCT	0.428													15	55					1.52009e-12	4.23415e-12	1	0	T	142292826	T	T	142292826	3	4	164	1	0	0	0	0	1	0	0	0	875	933	33	2	1034	2	ARHGAP26	5	142292826	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1524798	142292826	38622434	116	30014											
SGCD	6444	broad.mit.edu	37	chr5	156186321	156186321	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaggtcttcgagatctgcGtctgcgccaatgggagatta	10	10	13	8	3	3	3	0	0	3	3	4	5	3	3	1	2	2	0	1	2	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:156186321G>C	uc003lwd.3	+	8	1266	c.790G>C	c.(790-792)GTC>CTC	p.V264L	SGCD_uc003lwc.3_Missense_Mutation_p.V265L	NM_001128209	NP_001121681	Q92629	SGCD_HUMAN	delta-sarcoglycan isoform 3	264	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CGAGATCTGCGTCTGCGCCAA	0.488													23	77					0	0	0	0	C	156186321	C	C	156186321	3	2	164	1	0	0	0	0	1	0	0	0	14266	1145	40	3	895	3	SGCD	5	156186321	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	13893495	156186321	24728939	117	30015											
DOCK2	1794	broad.mit.edu	37	chr5	169468122	169468122	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacacagaggctgcctacacGctccttctccacacctggct	8	9	7	17	1	1	1	0	0	1	1	3	1	2	1	4	2	3	3	4	2	2	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:169468122G>C	uc003maf.2	+	37	3809	c.3729G>C	c.(3727-3729)ACG>ACC	p.T1243T	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.T735T	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1243	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGCCTACACGCTCCTTCTCC	0.502													3	23					0	0	0	0	C	169468122	C	C	169468122	2	2	164	1	0	0	0	0	0	0	0	1	4709	1074	38	3		3	DOCK2	5	169468122	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	13281801	169468122	11447138	118	30016											
ADAMTS2	9509	broad.mit.edu	37	chr5	178770999	178770999	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgactgccaggctcctcctcGttgcctccggggaagctcgg	4	9	13	15	3	0	1	0	1	0	0	5	2	3	2	5	4	3	3	5	4	1	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:178770999G>T	uc003mjw.2	-	2	303	c.303C>A	c.(301-303)AAC>AAA	p.N101K	ADAMTS2_uc011dgm.1_Missense_Mutation_p.N101K	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	101					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GCTCCTCCTCGTTGCCTCCGG	0.711													18	31					4.96729e-08	1.23137e-07	1	0	T	178770999	T	T	178770999	3	4	164	1	0	0	0	0	1	0	0	0	265	1136	40	3	3491	3	ADAMTS2	5	178770999	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	9302877	178770999	2144261	119	30017											
MAPK9	5601	broad.mit.edu	37	chr5	179666940	179666940	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacctttccattcttcaatTgcatgttctctttcttccaa	7	20	2	12	0	4	0	1	0	3	0	7	0	6	0	3	0	2	2	3	0	3	8			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:179666940T>C	uc003mls.3	-	10	1315	c.1044A>G	c.(1042-1044)GCA>GCG	p.A348A	MAPK9_uc003mlt.3_Silent_p.A348A|MAPK9_uc010jlc.2_Silent_p.A348A|MAPK9_uc003mlv.3_Silent_p.A348A	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	348					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATTCTTCAATTGCATGTTCTC	0.348													13	23					0	0	0	0	C	179666940	C	C	179666940	2	2	164	1	0	0	0	0	0	0	0	1	9340	1799	63	5		5	MAPK9	5	179666940	Silent	SNP	T	TCGA-CR-7399-01A-11D-2012-08	895941	179666940	1248320	120	30018											
FLT4	2324	broad.mit.edu	37	chr5	180043408	180043408	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggtctttgtagatgtcccGggcaaggccaaagtcacaga	10	8	14	9	1	2	2	1	0	1	2	3	2	3	2	2	4	0	2	2	4	3	2	rs68096331		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr5:180043408G>T	uc003mma.3	-	23	3257	c.3178C>A	c.(3178-3180)CGG>AGG	p.R1060R	FLT4_uc003mlz.3_Silent_p.R1060R	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	1060	Cytoplasmic (Potential).|Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TAGATGTCCCGGGCAAGGCCA	0.617									Congenital_Hereditary_Lymphedema				12	48					3.07112e-06	7.21618e-06	1	0	T	180043408	T	T	180043408	2	4	164	1	0	0	0	0	0	0	0	1	5976	1115	39	3		3	FLT4	5	180043408	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	376468	180043408	871852	121	30019											
MBOAT1	154141	broad.mit.edu	37	chr6	20102580	20102580	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcctttgcgtatgagcttgTggtttcattggcagaaatag	8	14	12	7	2	1	2	1	1	0	1	1	2	1	2	1	2	2	4	1	2	3	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:20102580T>C	uc003ncx.1	-	13	1630	c.1425A>G	c.(1423-1425)CCA>CCG	p.P475P	MBOAT1_uc011dji.1_Silent_p.P326P	NM_001080480	NP_001073949	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain	475					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			TATGAGCTTGTGGTTTCATTG	0.353													11	46					0	0	0	0	C	20102580	C	C	20102580	2	2	164	1	0	0	0	0	0	0	0	1	9409	1683	59	5		5	MBOAT1	6	20102580	Silent	SNP	T	TCGA-CR-7399-01A-11D-2012-08		20102580	151012487	122	30020											
OR5V1	81696	broad.mit.edu	37	chr6	29323758	29323758	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggacattgctggtggtgtagCagatgtcaataaaggccaag	12	9	14	6	0	1	1	1	0	0	1	1	2	1	2	1	4	2	3	1	4	5	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:29323758C>A	uc011dlo.1	-	1	297	c.215G>T	c.(214-216)TGC>TTC	p.C72F		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						GGTGGTGTAGCAGATGTCAAT	0.408													25	78					1.16021e-09	3.04356e-09	1	0	A	29323758	A	A	29323758	3	1	164	1	0	0	0	0	1	0	0	0	11238	710	25	4	753	4	OR5V1	6	29323758	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	9221178	29323758	141791309	123	30021											
ZFP57	346171	broad.mit.edu	37	chr6	29641451	29641451	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggggcactggccggcccctCtgcatgcaaggaagaccttg	7	6	15	13	1	1	1	0	0	1	1	1	2	1	2	4	5	2	3	4	5	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:29641451C>G	uc011dlw.1	-	4	588	c.437G>C	c.(436-438)AGA>ACA	p.R146T	ZFP57_uc003nnl.3_Missense_Mutation_p.R126T	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						GCCGGCCCCTCTGCATGCAAG	0.557													25	84					0	0	0	0	G	29641451	G	G	29641451	3	3	164	1	0	0	0	0	1	0	0	0	17718	913	32	2	1177	2	ZFP57	6	29641451	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	317693	29641451	141473616	124	30022											
KCNK16	83795	broad.mit.edu	37	chr6	39290287	39290287	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggggcagcacccggccaccCcagcagctgcagagcccagc	9	1	13	18	1	0	1	0	0	0	1	0	1	0	1	5	3	6	5	5	3	0	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:39290287C>A	uc003ooq.2	-	1	44	c.30G>T	c.(28-30)TGG>TGT	p.W10C	KCNK16_uc003oor.3_Missense_Mutation_p.W10C|KCNK16_uc010jwy.2_Missense_Mutation_p.W10C|KCNK16_uc011dtz.1_Missense_Mutation_p.W10C	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	10	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						CCCGGCCACCCCAGCAGCTGC	0.657													9	6					2.17888e-05	4.92336e-05	1	0	A	39290287	A	A	39290287	3	1	164	1	0	0	0	0	1	0	0	0	8102	624	22	4	1308	4	KCNK16	6	39290287	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	9648836	39290287	131824780	125	30023											
VEGFA	7422	broad.mit.edu	37	chr6	43749750	43749750	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtacaagatccgcagacGtgtaaatgttcctgcaaaaa	14	11	8	8	2	0	2	0	0	0	2	2	2	2	2	2	0	2	5	2	0	6	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:43749750G>A	uc003owh.2	+	7	1634	c.1143G>A	c.(1141-1143)ACG>ACA	p.T381T	VEGFA_uc003owd.2_Silent_p.T340T|VEGFA_uc003owf.2_Silent_p.T364T|VEGFA_uc003owe.2_Silent_p.T340T|VEGFA_uc003owg.2_Silent_p.T358T|VEGFA_uc003owi.2_Silent_p.T340T|VEGFA_uc003owj.2_Intron|VEGFA_uc010jyx.2_Intron|VEGFA_uc003owk.2_Intron	NM_001025366	NP_001020537	P15692	VEGFA_HUMAN	vascular endothelial growth factor A isoform a	201					basophil chemotaxis|cellular response to hypoxia|induction of positive chemotaxis|induction of positive chemotaxis|platelet activation|platelet degranulation|platelet-derived growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cell adhesion|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of leukocyte migration|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular permeability|regulation of cell shape|vascular endothelial growth factor receptor signaling pathway|vasculogenesis	cell surface|extracellular space|membrane|platelet alpha granule lumen	cell surface binding|chemoattractant activity|cytokine activity|fibronectin binding|growth factor activity|heparin binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|vascular endothelial growth factor receptor binding			ovary(1)|breast(1)	2	all_cancers(18;5.46e-07)|all_epithelial(2;5.96e-08)|Lung NSC(15;0.000157)|all_lung(25;0.000486)|Hepatocellular(11;0.00309)		all cancers(41;0.000413)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0742)|OV - Ovarian serous cystadenocarcinoma(102;0.196)		Atorvastatin(DB01076)|Bevacizumab(DB00112)|Carvedilol(DB01136)|Ginkgo biloba(DB01381)|Gliclazide(DB01120)|Minocycline(DB01017)|Ranibizumab(DB01270)|Simvastatin(DB00641)	ATCCGCAGACGTGTAAATGTT	0.493													6	28					0	0	0	0	A	43749750	A	A	43749750	2	1	164	1	0	0	0	0	0	0	0	1	17218	1132	40	1		1	VEGFA	6	43749750	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	4459463	43749750	127365317	126	30024											
ENPP4	22875	broad.mit.edu	37	chr6	46107690	46107690	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacctatttgggtgaccaatCagcttcaggaaaacagatca	14	10	8	9	0	3	2	3	1	0	1	3	3	3	3	2	2	3	1	2	2	5	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:46107690C>G	uc003oxy.2	+	2	629	c.370C>G	c.(370-372)CAG>GAG	p.Q124E		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	124	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						GGTGACCAATCAGCTTCAGGA	0.413													19	69					0	0	0	0	G	46107690	G	G	46107690	3	3	164	1	0	0	0	0	1	0	0	0	5156	827	29	2	372	2	ENPP4	6	46107690	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2357940	46107690	125007377	127	30025											
DST	667	broad.mit.edu	37	chr6	56371281	56371281	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacggcagcctgcattgccTcctcaagtttgtcaatccgg	8	10	10	13	2	2	0	2	0	0	0	4	1	4	0	4	2	4	3	4	2	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:56371281T>A	uc003pdf.2	-	71	13095	c.13067A>T	c.(13066-13068)GAG>GTG	p.E4356V	DST_uc003pcz.3_Missense_Mutation_p.E4178V|DST_uc011dxj.1_Missense_Mutation_p.E4207V|DST_uc011dxk.1_Missense_Mutation_p.E4218V|DST_uc003pcy.3_Missense_Mutation_p.E3852V	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6264	Spectrin 13.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTGCATTGCCTCCTCAAGTTT	0.418													5	32					0	0	0	0	A	56371281	A	A	56371281	3	1	164	1	0	0	0	0	1	0	0	0	4805	1551	54	5	4068	5	DST	6	56371281	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	10263591	56371281	114743786	128	30026											
COX7A2	1347	broad.mit.edu	37	chr6	75953557	75953557	+	5'Flank	DEL	A	-	-																															gcgtatgcattcacgaacttAaatctttccgggccgaagag																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:75953557delA	uc003phv.1	-							NM_001865	NP_001856	P14406	CX7A2_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 2							mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0						TCACGAACTTAAATCTTTCCG	0.542													---	---	---								-	75953557	-	-	75953557	6	5	164	0	1	1	0	1	0	0	0	0	3795	377	13	0		0	COX7A2	6	75953557	5'Flank	DEL	A	TCGA-CR-7399-01A-11D-2012-08	19582276	75953557	95161510	129	30027											
IMPG1	3617	broad.mit.edu	37	chr6	76728538	76728538	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagacgctgagctccaccCtctgctcctccaacacagcg	9	6	9	17	2	1	2	0	1	1	1	4	4	4	2	4	0	4	3	4	0	1	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:76728538C>A	uc003pik.1	-	7	834	c.704G>T	c.(703-705)AGG>ATG	p.R235M		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	235	SEA 1.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GAGCTCCACCCTCTGCTCCTC	0.433													9	27					0.000274275	0.000590154	1	0	A	76728538	A	A	76728538	3	1	164	1	0	0	0	0	1	0	0	0	7767	681	24	4	1733	4	IMPG1	6	76728538	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	774981	76728538	94386529	130	30028											
NUS1	116150	broad.mit.edu	37	chr6	118015291	118015291	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttgccagttagtagcccaGaagcaaaagagacccacaga	15	7	9	10	0	0	3	0	0	0	3	0	4	0	3	3	0	3	3	3	0	5	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:118015291G>A	uc003pxw.2	+	3	856	c.639G>A	c.(637-639)CAG>CAA	p.Q213Q		NM_138459	NP_612468	Q96E22	NGBR_HUMAN	nuclear undecaprenyl pyrophosphate synthase 1	213	Cytoplasmic (Potential).				angiogenesis|cell differentiation	integral to membrane	receptor activity|transferase activity, transferring alkyl or aryl (other than methyl) groups			central_nervous_system(1)	1		all_cancers(87;0.0395)|all_epithelial(87;0.0301)		GBM - Glioblastoma multiforme(226;0.02)|OV - Ovarian serous cystadenocarcinoma(136;0.115)|all cancers(137;0.146)		TAGTAGCCCAGAAGCAAAAGA	0.338													5	73					0	0	0	0	A	118015291	A	A	118015291	2	1	164	1	0	0	0	0	0	0	0	1	10831	933	33	2		2	NUS1	6	118015291	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	41286753	118015291	53099776	131	30029											
C6orf170	221322	broad.mit.edu	37	chr6	121526220	121526220	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagtaaaatgtagcattttaCcttagaccaaagatatgtga	17	12	7	5	0	0	3	0	1	0	2	0	3	0	3	2	0	2	3	2	0	8	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:121526220C>T	uc003pyo.1	-	22	2638	c.2570_splice	c.e22+1	p.R857_splice	C6orf170_uc003pyq.1_Splice_Site|C6orf170_uc010kej.1_Intron|C6orf170_uc003pyp.1_Splice_Site_p.R376_splice	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322						multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		TAGCATTTTACCTTAGACCAA	0.239													15	36					0	0	0	0	T	121526220	T	T	121526220	5	4	164	1	0	0	0	0	0	0	1	0	2354	521	18	4	1246	4	C6orf170	6	121526220	Splice_Site	SNP	C	TCGA-CR-7399-01A-11D-2012-08	3510929	121526220	49588847	132	30030											
GRM1	2911	broad.mit.edu	37	chr6	146480525	146480525	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggacgctttcaaagagctgGctgcccaggaaggcctctgt	8	9	13	11	1	2	1	1	0	1	1	2	3	2	3	2	4	2	3	2	4	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:146480525G>T	uc010khw.1	+	3	1212	c.742G>T	c.(742-744)GCT>TCT	p.A248S	GRM1_uc010khu.1_Missense_Mutation_p.A248S|GRM1_uc010khv.1_Missense_Mutation_p.A248S|GRM1_uc003qll.2_Missense_Mutation_p.A248S|GRM1_uc011edz.1_Missense_Mutation_p.A248S|GRM1_uc011eea.1_Missense_Mutation_p.A248S	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	248	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CAAAGAGCTGGCTGCCCAGGA	0.502													17	55					2.35188e-11	6.41118e-11	1	0	T	146480525	T	T	146480525	3	4	164	1	0	0	0	0	1	0	0	0	6835	1203	42	4	748	4	GRM1	6	146480525	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	24954305	146480525	24634542	133	30031											
TAB2	23118	broad.mit.edu	37	chr6	149719163	149719163	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actccagattgacattgactGcttaaccaaagaaattgatc	15	11	6	9	0	0	5	0	3	0	2	2	5	1	5	2	0	2	1	2	0	3	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:149719163G>A	uc003qmj.2	+	5	2001	c.1823G>A	c.(1822-1824)TGC>TAC	p.C608Y	TAB2_uc011eec.1_Missense_Mutation_p.C576Y|TAB2_uc003qmk.3_RNA|SUMO4_uc003qml.2_5'Flank	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	608	Potential.				activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						GACATTGACTGCTTAACCAAA	0.353													5	16					0	0	0	0	A	149719163	A	A	149719163	3	1	164	1	0	0	0	0	1	0	0	0	15562	1319	46	4	1837	4	TAB2	6	149719163	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3238638	149719163	21395904	134	30032											
LPA	4018	broad.mit.edu	37	chr6	161015034	161015034	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgatgccagtgtggtgtCatagaggaccaagactgaca	11	9	12	9	0	2	4	1	2	1	2	2	5	2	5	2	2	1	0	2	2	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr6:161015034C>T	uc003qtl.2	-	23	3705	c.3585G>A	c.(3583-3585)ATG>ATA	p.M1195I		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3703	Kringle 33.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AGTGTGGTGTCATAGAGGACC	0.488													14	63					0	0	0	0	T	161015034	T	T	161015034	3	4	164	1	0	0	0	0	1	0	0	0	8953	826	29	2	2609	2	LPA	6	161015034	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	11295871	161015034	10100033	135	30033											
CRHR2	1395	broad.mit.edu	37	chr7	30706892	30706892	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagtagttgatctttgaggcCcacgtcccattctccaagca	9	11	9	12	1	2	2	0	2	2	0	4	3	3	2	3	1	1	3	3	1	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:30706892C>T	uc003tbn.2	-	3	511	c.267G>A	c.(265-267)TGG>TGA	p.W89*	CRHR2_uc010kvw.1_Nonsense_Mutation_p.W89*|CRHR2_uc010kvx.1_Nonsense_Mutation_p.W89*|CRHR2_uc010kvy.1_Intron|CRHR2_uc003tbo.2_Nonsense_Mutation_p.W75*|CRHR2_uc003tbp.2_Nonsense_Mutation_p.W116*	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	89	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						TCTTTGAGGCCCACGTCCCAT	0.532													8	58					0	0	0	0	T	30706892	T	T	30706892	4	4	164	1	0	0	0	0	0	1	0	0	3887	624	22	4	1008	4	CRHR2	7	30706892	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08		30706892	128431771	136	30034											
HGF	3082	broad.mit.edu	37	chr7	81386541	81386541	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatggaactccagggctgaCatttgatgccactcttagtg	9	12	10	10	0	2	2	1	2	1	0	3	3	3	3	2	2	2	1	2	2	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:81386541C>T	uc003uhl.2	-	4	611	c.446G>A	c.(445-447)TGT>TAT	p.C149Y	HGF_uc003uhm.2_Missense_Mutation_p.C149Y|HGF_uc003uhn.1_Missense_Mutation_p.C149Y|HGF_uc003uho.1_Missense_Mutation_p.C149Y|HGF_uc003uhp.2_Missense_Mutation_p.C149Y	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	149	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						CCAGGGCTGACATTTGATGCC	0.383													16	34					0	0	0	0	T	81386541	T	T	81386541	3	4	164	1	0	0	0	0	1	0	0	0	7124	478	17	4	1820	4	HGF	7	81386541	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	50679649	81386541	77752122	137	30035											
KIAA1324L	222223	broad.mit.edu	37	chr7	86569411	86569411	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctccagtagagtatgttTgtgcctgatttcagcattac	8	16	9	8	0	2	2	1	1	1	1	3	2	2	2	2	0	3	5	2	0	3	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:86569411T>G	uc011kha.1	-	6	947	c.762A>C	c.(760-762)ACA>ACC	p.T254T	KIAA1324L_uc003uif.1_Silent_p.T14T|KIAA1324L_uc011kgz.1_Silent_p.T140T|KIAA1324L_uc003uie.2_Silent_p.T87T	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	254	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					AGAGTATGTTTGTGCCTGATT	0.398													12	43					0	0	0	0	G	86569411	G	G	86569411	2	3	164	1	0	0	0	0	0	0	0	1	8263	1799	63	5		5	KIAA1324L	7	86569411	Silent	SNP	T	TCGA-CR-7399-01A-11D-2012-08	5182870	86569411	72569252	138	30036											
AKAP9	10142	broad.mit.edu	37	chr7	91694575	91694575	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagacagaaaaattaatgaAggaaaaactagaagtacaat	23	6	9	3	0	0	4	0	1	0	3	0	6	0	5	0	2	2	1	0	2	10	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:91694575A>G	uc003ulg.2	+	25	6233	c.6008A>G	c.(6007-6009)AAG>AGG	p.K2003R	AKAP9_uc003ulf.2_Missense_Mutation_p.K2003R|AKAP9_uc003uli.2_Missense_Mutation_p.K1626R	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2015	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAATTAATGAAGGAAAAACTA	0.299			T	BRAF	papillary thyroid								28	27					0	0	0	0	G	91694575	G	G	91694575	3	3	164	1	0	0	0	0	1	0	0	0	459	72	3	5	6106	5	AKAP9	7	91694575	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	5125164	91694575	67444088	139	30037											
GJC3	349149	broad.mit.edu	37	chr7	99526840	99526840	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagctgagccacataagccCagagcagcctgaggcttcca	11	5	10	15	0	0	3	0	2	0	1	1	3	1	3	5	1	5	3	5	1	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:99526840C>A	uc011kjd.1	-	1	404	c.404G>T	c.(403-405)TGG>TTG	p.W135L		NM_181538	NP_853516	Q8NFK1	CXG3_HUMAN	gap junction protein, gamma 3, 30.2kDa	135	Helical; (Potential).					connexon complex|integral to membrane				ovary(1)	1	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CACATAAGCCCAGAGCAGCCT	0.617													35	208					1.21669e-08	3.08605e-08	1	0	A	99526840	A	A	99526840	3	1	164	1	0	0	0	0	1	0	0	0	6453	595	21	4	443	4	GJC3	7	99526840	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	7832265	99526840	59611823	140	30038											
AZGP1	563	broad.mit.edu	37	chr7	99565930	99565930	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgggtcgaaggggaccCaggctgggatttctttgttg	5	12	16	8	1	1	0	0	0	1	0	2	3	1	2	1	5	1	3	1	5	1	3	rs145427176		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:99565930C>T	uc003ush.2	-	3	505	c.461G>A	c.(460-462)TGG>TAG	p.W154*		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	154					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity	p.W154S(1)		ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					GAAGGGGACCCAGGCTGGGAT	0.507													49	274					0	0	0	0	T	99565930	T	T	99565930	4	4	164	1	0	0	0	0	0	1	0	0	1241	595	21	4	443	4	AZGP1	7	99565930	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	39090	99565930	59572733	141	30039											
C7orf51	222950	broad.mit.edu	37	chr7	100086152	100086152	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agatgaagtacccgctgccgGaagaggctggggaaggccgg	10	4	18	9	3	0	3	0	1	0	2	0	5	0	5	3	6	2	3	3	6	4	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:100086152G>A	uc003uvd.1	+	4	967	c.808G>A	c.(808-810)GAA>AAA	p.E270K	C7orf51_uc003uve.1_Missense_Mutation_p.E52K	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	270										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCCGCTGCCGGAAGAGGCTGG	0.687													16	87					0	0	0	0	A	100086152	A	A	100086152	3	1	164	1	0	0	0	0	1	0	0	0	2411	1175	41	2	818	2	C7orf51	7	100086152	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	520222	100086152	59052511	142	30040											
LRRN3	54674	broad.mit.edu	37	chr7	110763775	110763775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agatttaagaaaaatagaagCtactaacaaccctagattgt	19	10	6	6	0	0	4	0	0	0	4	0	4	0	4	1	0	4	1	1	0	9	7			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:110763775C>T	uc003vft.3	+	4	1993	c.947C>T	c.(946-948)GCT>GTT	p.A316V	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.A316V|LRRN3_uc003vfs.3_Missense_Mutation_p.A316V	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	316	Extracellular (Potential).|LRR 11.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		AAAATAGAAGCTACTAACAAC	0.418													19	42					0	0	0	0	T	110763775	T	T	110763775	3	4	164	1	0	0	0	0	1	0	0	0	9086	797	28	4	949	4	LRRN3	7	110763775	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	10677623	110763775	48374888	143	30041											
C7orf60	154743	broad.mit.edu	37	chr7	112462106	112462106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaattttgagtacttgaagCgtttaaagcccagggactct	13	12	9	7	1	1	2	0	2	1	0	1	3	1	3	1	1	3	2	1	1	6	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:112462106C>T	uc003vgo.1	-	5	1038	c.911G>A	c.(910-912)CGC>CAC	p.R304H	C7orf60_uc011kms.1_Missense_Mutation_p.R330H	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	304										ovary(2)|skin(1)	3						GTACTTGAAGCGTTTAAAGCC	0.398													15	39					0	0	0	0	T	112462106	T	T	112462106	3	4	164	1	0	0	0	0	1	0	0	0	2418	768	27	1	310	1	C7orf60	7	112462106	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1698331	112462106	46676557	144	30042											
POT1	25913	broad.mit.edu	37	chr7	124482972	124482972	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaggagctttttgtttcaaaAtggcacatagtggtgtcctc	9	14	11	7	0	1	0	1	0	0	0	3	2	2	1	1	3	1	3	1	3	3	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:124482972A>G	uc003vlm.2	-	13	1653	c.1052T>C	c.(1051-1053)ATT>ACT	p.I351T	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.I220T|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	351					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						TTGTTTCAAAATGGCACATAG	0.348													5	32					0	0	0	0	G	124482972	G	G	124482972	3	3	164	1	0	0	0	0	1	0	0	0	12315	101	4	5	880	5	POT1	7	124482972	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	12020866	124482972	34655691	145	30043											
OR2A25	392138	broad.mit.edu	37	chr7	143771537	143771537	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacatcgcctgtgcttgcagCacggtgccccagatgctggt	6	9	13	13	2	0	1	0	0	0	1	1	2	0	1	3	2	5	4	3	2	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:143771537C>A	uc011ktx.1	+	1	225	c.225C>A	c.(223-225)AGC>AGA	p.S75R		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GTGCTTGCAGCACGGTGCCCC	0.557													37	44					3.62531e-18	1.05589e-17	1	0	A	143771537	A	A	143771537	3	1	164	1	0	0	0	0	1	0	0	0	11032	709	25	4	227	4	OR2A25	7	143771537	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	19288565	143771537	15367126	146	30044											
SSPO	23145	broad.mit.edu	37	chr7	149481149	149481149	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggccagtgtgtgcccccCagcttgtgcccctgccagct	4	8	13	16	0	0	0	0	0	0	0	0	1	0	0	7	1	5	2	7	1	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:149481149C>G	uc010lpk.2	+	18	2631	c.2631C>G	c.(2629-2631)CCC>CCG	p.P877P	SSPO_uc010lpl.1_Silent_p.P212P	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	877	TIL 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTGTGCCCCCCAGCTTGTGCC	0.657													3	14					0	0	0	0	G	149481149	G	G	149481149	2	3	164	1	0	0	0	0	0	0	0	1	15255	581	21	4		4	SSPO	7	149481149	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	5709612	149481149	9657514	147	30045											
GIMAP8	155038	broad.mit.edu	37	chr7	150174635	150174635	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagataacaaagcccttcggCgcatttttaaaaagtgtggg	13	10	10	8	2	0	1	0	0	0	1	1	1	0	1	1	2	2	1	1	2	5	5	rs139453539		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:150174635C>T	uc003whj.2	+	5	2095	c.1765C>T	c.(1765-1767)CGC>TGC	p.R589C		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	589						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding	p.R589H(1)		skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		AGCCCTTCGGCGCATTTTTAA	0.463													16	83					0	0	0	0	T	150174635	T	T	150174635	3	4	164	1	0	0	0	0	1	0	0	0	6422	768	27	1	1779	1	GIMAP8	7	150174635	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	693486	150174635	8964028	148	30046											
HTR5A	3361	broad.mit.edu	37	chr7	154875975	154875975	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaaggagcagcgggccgcCctcatggtgggcatcctcat	8	6	14	13	2	2	1	2	0	0	1	3	2	3	2	3	4	2	2	3	4	1	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr7:154875975C>G	uc003wlu.1	+	2	916	c.852C>G	c.(850-852)GCC>GCG	p.A284A		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	284	Helical; Name=6; (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		AGCGGGCCGCCCTCATGGTGG	0.637													24	45					0	0	0	0	G	154875975	G	G	154875975	2	3	164	1	0	0	0	0	0	0	0	1	7489	610	22	4		4	HTR5A	7	154875975	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	4701340	154875975	4262688	149	30047											
DLGAP2	9228	broad.mit.edu	37	chr8	1497072	1497072	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcgtgatgatgccggtggtGctgggcgaccacgtgtccag	5	9	17	10	4	0	2	0	2	0	0	1	3	1	2	3	3	3	1	3	3	0	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:1497072G>T	uc003wpl.2	+	2	310	c.213G>T	c.(211-213)GTG>GTT	p.V71V	DLGAP2_uc003wpm.2_Silent_p.V71V	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	150					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TGCCGGTGGTGCTGGGCGACC	0.721													4	18					1.23904e-05	2.82472e-05	1	0	T	1497072	T	T	1497072	2	4	164	1	0	0	0	0	0	0	0	1	4582	1306	46	4		4	DLGAP2	8	1497072	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08		1497072	144866950	150	30048											
ANGPT2	285	broad.mit.edu	37	chr8	6378820	6378820	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttttctagttcttcaatGatggaattttgcttggatac	8	21	7	5	0	3	1	1	1	2	0	3	3	3	3	0	2	2	2	0	2	4	10			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:6378820G>A	uc003wqj.3	-	4	1007	c.678C>T	c.(676-678)ATC>ATT	p.I226I	MCPH1_uc003wqi.2_Intron|ANGPT2_uc003wqk.3_Silent_p.I226I|ANGPT2_uc010lri.2_Silent_p.I174I|ANGPT2_uc003wql.3_Silent_p.I226I	NM_001147	NP_001138	O15123	ANGP2_HUMAN	angiopoietin 2 isoform a precursor	226	Potential.				angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			upper_aerodigestive_tract(1)	1		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		GTTCTTCAATGATGGAATTTT	0.373													8	42					0	0	0	0	A	6378820	A	A	6378820	2	1	164	1	0	0	0	0	0	0	0	1	611	1280	45	2		2	ANGPT2	8	6378820	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	4881748	6378820	139985202	151	30049											
FAM160B2	64760	broad.mit.edu	37	chr8	21957263	21957263	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctcctcacagccatgctGcgccagcttcgctcccctgc	4	8	8	21	2	1	0	1	0	0	0	4	0	3	0	6	0	5	3	6	0	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:21957263G>C	uc011kyx.1	+	10	1251	c.1200G>C	c.(1198-1200)CTG>CTC	p.L400L	FAM160B2_uc011kyy.1_RNA	NM_022749	NP_073586	Q86V87	F16B2_HUMAN	retinoic acid induced 16	400											0						CAGCCATGCTGCGCCAGCTTC	0.672													11	38					0	0	0	0	C	21957263	C	C	21957263	2	2	164	1	0	0	0	0	0	0	0	1	5499	1306	46	4		4	FAM160B2	8	21957263	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	15578443	21957263	124406759	152	30050											
ADAM7	8756	broad.mit.edu	37	chr8	24334017	24334017	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggtcaattttgtcaacatGgtaagatttgatacagtttt	12	17	8	4	0	2	2	2	1	0	1	2	2	2	2	0	2	2	2	0	2	4	7			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:24334017G>A	uc003xeb.2	+	8	818	c.705G>A	c.(703-705)ATG>ATA	p.M235I	ADAM7_uc003xec.2_Missense_Mutation_p.M7I	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	235	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TTGTCAACATGGTAAGATTTG	0.333													6	19					0	0	0	0	A	24334017	A	A	24334017	3	1	164	1	0	0	0	0	1	0	0	0	251	1362	47	4	735	4	ADAM7	8	24334017	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2376754	24334017	122030005	153	30051											
ADAM7	8756	broad.mit.edu	37	chr8	24358343	24358343	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgcttgtcctggttattgtCggtatcggagttcttatact	5	18	11	7	2	1	0	0	0	1	0	4	1	2	1	1	3	2	4	1	3	4	7	rs149009178		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:24358343C>T	uc003xeb.2	+	19	2156	c.2043C>T	c.(2041-2043)GTC>GTT	p.V681V	ADAM7_uc003xec.2_Silent_p.V453V	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	681	Helical; (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TGGTTATTGTCGGTATCGGAG	0.378													16	70					0	0	0	0	T	24358343	T	T	24358343	2	4	164	1	0	0	0	0	0	0	0	1	251	871	31	1		1	ADAM7	8	24358343	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	24326	24358343	122005679	154	30052											
ADRA1A	148	broad.mit.edu	37	chr8	26628171	26628171	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcagagggcttgaaatcaGggaagaaagaccctggaaga	15	7	13	6	0	2	5	2	1	0	4	2	7	2	7	1	3	0	1	1	3	4	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:26628171G>T	uc003xfh.1	-	2	1332	c.896C>A	c.(895-897)CCT>CAT	p.P299H	ADRA1A_uc003xfc.1_Missense_Mutation_p.P299H|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Missense_Mutation_p.P299H|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron|ADRA1A_uc003xfg.1_Missense_Mutation_p.P299H	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	299	Extracellular (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	CTTGAAATCAGGGAAGAAAGA	0.393													12	58					5.50884e-06	1.27485e-05	1	0	T	26628171	T	T	26628171	3	4	164	1	0	0	0	0	1	0	0	0	334	1000	35	4	799	4	ADRA1A	8	26628171	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2269828	26628171	119735851	155	30053											
FZD3	7976	broad.mit.edu	37	chr8	28413285	28413285	+	Frame_Shift_Del	DEL	G	-	-																															gagagccgacaggtactccaGgaacctgattttgctcagtc																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:28413285delG	uc003xgx.2	+	7	2062	c.1584delG	c.(1582-1584)CAGfs	p.Q528fs	FZD3_uc010lvb.2_Frame_Shift_Del_p.Q528fs	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	528	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		AGGTACTCCAGGAACCTGATT	0.418													---	---	---								-	28413285	-	-	28413285	7	5	164	1	0	1	0	1	0	0	0	0	6165	991	35	0	1602	0	FZD3	8	28413285	Frame_Shift_Del	DEL	G	TCGA-CR-7399-01A-11D-2012-08	1785114	28413285	117950737	156	30054											
LETM2	137994	broad.mit.edu	37	chr8	38258566	38258566	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagtctataaaagcagatGatgaagtaagagcttaacca	18	9	9	5	0	1	5	0	3	1	2	1	5	1	5	1	0	3	3	1	0	7	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:38258566G>A	uc003xlm.1	+	6	1009	c.838G>A	c.(838-840)GAT>AAT	p.D280N	LETM2_uc011lbn.1_Missense_Mutation_p.D124N|LETM2_uc003xll.1_Missense_Mutation_p.D232N|LETM2_uc003xln.1_Missense_Mutation_p.D124N|LETM2_uc003xlo.1_Missense_Mutation_p.D124N	NM_144652	NP_653253	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane	327	LETM1.|Mitochondrial matrix (Potential).					integral to membrane|mitochondrial inner membrane					0	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			AAAAGCAGATGATGAAGTAAG	0.428													32	46					0	0	0	0	A	38258566	A	A	38258566	3	1	164	1	0	0	0	0	1	0	0	0	8775	1290	45	2	704	2	LETM2	8	38258566	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	9845281	38258566	108105456	157	30055											
ADAM32	203102	broad.mit.edu	37	chr8	39022556	39022556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttctgtttttagatgttcaCccaatttaaagttactattg	10	19	5	7	0	2	1	1	0	1	1	2	1	2	1	1	0	1	3	1	0	6	10			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:39022556C>T	uc003xmt.3	+	9	919	c.674C>T	c.(673-675)ACC>ATC	p.T225I	ADAM32_uc011lch.1_Missense_Mutation_p.T232I|ADAM32_uc003xmu.3_Missense_Mutation_p.T225I	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	225	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TAGATGTTCACCCAATTTAAA	0.294													20	60					0	0	0	0	T	39022556	T	T	39022556	3	4	164	1	0	0	0	0	1	0	0	0	249	507	18	4	708	4	ADAM32	8	39022556	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	763990	39022556	107341466	158	30056											
CSPP1	79848	broad.mit.edu	37	chr8	68044264	68044264	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgatttttgaagataaaccGaaaccttccaaacagtcact	15	12	5	9	1	1	3	1	2	0	1	2	4	2	3	3	0	3	0	3	0	5	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:68044264G>A	uc003xxi.2	+	16	1897	c.1866G>A	c.(1864-1866)CCG>CCA	p.P622P	CSPP1_uc003xxg.1_Silent_p.P614P|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Silent_p.P587P|CSPP1_uc003xxk.2_Silent_p.P293P	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	622						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAGATAAACCGAAACCTTCCA	0.353													11	60					0	0	0	0	A	68044264	A	A	68044264	2	1	164	1	0	0	0	0	0	0	0	1	3979	1045	37	1		1	CSPP1	8	68044264	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	29021708	68044264	78319758	159	30057											
EYA1	2138	broad.mit.edu	37	chr8	72211956	72211956	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgttgtaaaactgctacCtaaaacaaaatgaaaagaaa	21	9	6	5	0	0	3	0	2	0	1	0	3	0	3	1	0	4	3	1	0	10	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:72211956C>A	uc003xys.3	-	7	844	c.557_splice	c.e7-1	p.G186_splice	EYA1_uc003xyr.3_Splice_Site_p.G181_splice|EYA1_uc003xyt.3_Splice_Site_p.G153_splice|EYA1_uc010lzf.2_Splice_Site_p.G113_splice|EYA1_uc003xyu.2_Splice_Site_p.G186_splice|EYA1_uc011lfe.1_Splice_Site_p.G180_splice|EYA1_uc003xyv.2_Splice_Site_p.G64_splice	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b						double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			AAACTGCTACCTAAAACAAAA	0.323													21	87					2.4624e-09	6.35083e-09	1	0	A	72211956	A	A	72211956	5	1	164	1	0	0	0	0	0	0	1	0	5353	695	24	4	1266	4	EYA1	8	72211956	Splice_Site	SNP	C	TCGA-CR-7399-01A-11D-2012-08	4167692	72211956	74152066	160	30058											
KCNB2	9312	broad.mit.edu	37	chr8	73480118	73480118	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctcaaccacgaagtcctgtGgagaacgctggacaggctgc	10	6	12	13	2	1	1	1	0	0	1	2	4	2	2	3	3	3	2	3	3	3	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:73480118G>T	uc003xzb.2	+	2	737	c.149G>T	c.(148-150)TGG>TTG	p.W50L		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	50	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GAAGTCCTGTGGAGAACGCTG	0.557													41	87					8.48111e-28	2.57799e-27	1	0	T	73480118	T	T	73480118	3	4	164	1	0	0	0	0	1	0	0	0	8052	1357	47	4	151	4	KCNB2	8	73480118	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1268162	73480118	72883904	161	30059											
FAM164A	51101	broad.mit.edu	37	chr8	79598715	79598715	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttatagccagaaccaccaaAgaaaccatctaattggagaa	18	8	6	9	0	1	3	0	0	1	3	1	4	1	3	4	1	3	0	4	1	7	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:79598715A>G	uc003ybd.2	+	4	326	c.224A>G	c.(223-225)AAG>AGG	p.K75R		NM_016010	NP_057094	Q96GY0	F164A_HUMAN	hypothetical protein LOC51101	75										ovary(1)	1						GAACCACCAAAGAAACCATCT	0.313													3	9					0	0	0	0	G	79598715	G	G	79598715	3	3	164	1	0	0	0	0	1	0	0	0	5506	72	3	5	238	5	FAM164A	8	79598715	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	6118597	79598715	66765307	162	30060											
GEM	2669	broad.mit.edu	37	chr8	95272561	95272561	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgtggagtcagaggaccaGcttcggcggcagtggtcctc	6	9	15	11	2	2	1	1	0	1	1	5	3	3	3	2	5	1	2	2	5	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:95272561G>T	uc003ygj.2	-	2	420	c.171C>A	c.(169-171)AGC>AGA	p.S57R	GEM_uc003ygi.2_Missense_Mutation_p.S57R	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein	57					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			CAGAGGACCAGCTTCGGCGGC	0.602													8	71					5.18039e-06	1.20248e-05	1	0	T	95272561	T	T	95272561	3	4	164	1	0	0	0	0	1	0	0	0	6366	962	34	4	735	4	GEM	8	95272561	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	15673846	95272561	51091461	163	30061											
GDF6	392255	broad.mit.edu	37	chr8	97156802	97156802	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcaccgctacctgcagcCgcacgactccaccaccatgt	10	5	8	18	3	0	0	0	0	0	0	1	1	1	0	6	1	3	4	6	1	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:97156802C>T	uc003yhp.2	-	2	1457	c.1357G>A	c.(1357-1359)GGC>AGC	p.G453S		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	453					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)					TACCTGCAGCCGCACGACTCC	0.622													5	15					0	0	0	0	T	97156802	T	T	97156802	3	4	164	1	0	0	0	0	1	0	0	0	6354	652	23	1	14	1	GDF6	8	97156802	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1884241	97156802	49207220	164	30062											
VPS13B	157680	broad.mit.edu	37	chr8	100874157	100874157	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgacagggcctgtcccggcTgggcatcagcctgcttggta	5	9	14	13	2	1	0	1	0	0	0	3	1	2	0	3	4	2	4	3	4	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:100874157T>A	uc003yiv.2	+	58	11384	c.11273T>A	c.(11272-11274)CTG>CAG	p.L3758Q	VPS13B_uc003yiw.2_Missense_Mutation_p.L3733Q	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3758					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTGTCCCGGCTGGGCATCAGC	0.672													3	7					0	0	0	0	A	100874157	A	A	100874157	3	1	164	1	0	0	0	0	1	0	0	0	17258	1580	55	5	11693	5	VPS13B	8	100874157	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	3717355	100874157	45489865	165	30063											
DPYS	1807	broad.mit.edu	37	chr8	105463544	105463544	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttgggatcagcccagcttCgccaggtctcgaaggcctca	7	9	11	14	2	3	0	2	0	1	0	5	2	3	1	3	3	2	1	3	3	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:105463544C>T	uc003yly.3	-	2	482	c.353G>A	c.(352-354)CGA>CAA	p.R118Q		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	118					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AGCCCAGCTTCGCCAGGTCTC	0.522													10	52					0	0	0	0	T	105463544	T	T	105463544	3	4	164	1	0	0	0	0	1	0	0	0	4768	884	31	1	1238	1	DPYS	8	105463544	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	4589387	105463544	40900478	166	30064											
CSMD3	114788	broad.mit.edu	37	chr8	113243843	113243843	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaatacataagtagctcCatcaggctcagcagaaacct	15	9	7	10	0	2	2	2	1	0	1	3	2	3	2	2	1	4	4	2	1	5	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:113243843C>A	uc003ynu.2	-	69	10918	c.10759G>T	c.(10759-10761)GGA>TGA	p.G3587*	CSMD3_uc003yns.2_Nonsense_Mutation_p.G2789*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.G3547*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.G3418*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3587	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAAGTAGCTCCATCAGGCTCA	0.323										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	112					0.000151284	0.000332046	1	0	A	113243843	A	A	113243843	4	1	164	1	0	0	0	0	0	1	0	0	3963	603	21	4	376	4	CSMD3	8	113243843	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	7780299	113243843	33120179	167	30065											
ADCY8	114	broad.mit.edu	37	chr8	131916241	131916241	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catggccctcttccacgttaTagtcaccgttgagacagtcc	8	11	8	14	2	2	1	1	1	1	1	4	2	4	1	4	1	0	2	4	1	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:131916241T>C	uc003ytd.3	-	7	1944	c.1688A>G	c.(1687-1689)TAT>TGT	p.Y563C	ADCY8_uc010mds.2_Missense_Mutation_p.Y563C	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	563	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TTCCACGTTATAGTCACCGTT	0.468										HNSCC(32;0.087)			35	211					0	0	0	0	C	131916241	C	C	131916241	3	2	164	1	0	0	0	0	1	0	0	0	300	1406	49	5	2115	5	ADCY8	8	131916241	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	18672398	131916241	14447781	168	30066											
KCNQ3	3786	broad.mit.edu	37	chr8	133141603	133141603	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctgggcgtgaaggggtccGtgtctgtgtccgtctcaccc	3	10	15	13	4	2	1	1	1	2	0	5	1	4	1	3	3	0	1	3	3	1	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:133141603G>A	uc003ytj.2	-	15	2750	c.2525C>T	c.(2524-2526)ACG>ATG	p.T842M	KCNQ3_uc010mdt.2_Missense_Mutation_p.T830M|uc003yti.2_5'Flank	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	842					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GAAGGGGTCCGTGTCTGTGTC	0.572													8	52					0	0	0	0	A	133141603	A	A	133141603	3	1	164	1	0	0	0	0	1	0	0	0	8123	1145	40	1	97	1	KCNQ3	8	133141603	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1225362	133141603	13222419	169	30067											
KCNQ3	3786	broad.mit.edu	37	chr8	133142133	133142133	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttctctgcttcagctggCgaggaggtgcccttggttgg	3	14	14	10	1	3	0	1	0	2	0	4	2	3	1	1	5	3	3	1	5	0	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:133142133C>A	uc003ytj.2	-	15	2220	c.1995G>T	c.(1993-1995)TCG>TCT	p.S665S	KCNQ3_uc010mdt.2_Silent_p.S653S	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	665					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CTTCAGCTGGCGAGGAGGTGC	0.532													17	115					3.32936e-07	8.09616e-07	1	0	A	133142133	A	A	133142133	2	1	164	1	0	0	0	0	0	0	0	1	8123	755	27	3		3	KCNQ3	8	133142133	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	530	133142133	13221889	170	30068											
KHDRBS3	10656	broad.mit.edu	37	chr8	136594270	136594270	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggagtccccccaactgggtAcagacctccaccgccacccc	9	4	8	20	1	0	1	0	0	0	1	2	2	2	2	9	2	2	1	9	2	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:136594270A>T	uc003yuv.2	+	6	1155	c.761A>T	c.(760-762)TAC>TTC	p.Y254F	KHDRBS3_uc003yuw.2_Missense_Mutation_p.Y254F|KHDRBS3_uc010mek.2_RNA	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	254	Pro-rich.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			CCAACTGGGTACAGACCTCCA	0.557													6	56					0	0	0	0	T	136594270	T	T	136594270	3	4	164	1	0	0	0	0	1	0	0	0	8187	391	14	5	783	5	KHDRBS3	8	136594270	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	3452137	136594270	9769752	171	30069											
FAM135B	51059	broad.mit.edu	37	chr8	139323163	139323163	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtcactcggatctggtaataCctaagaaaagagaagaggac	16	7	11	7	1	2	3	1	0	1	3	3	6	2	5	1	3	1	1	1	3	6	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:139323163C>T	uc003yuy.2	-	3	249	c.78G>A	c.(76-78)GGG>GGA	p.G26G	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	26										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCTGGTAATACCTAAGAAAAG	0.468										HNSCC(54;0.14)			10	55					0	0	0	0	T	139323163	T	T	139323163	2	4	164	1	0	0	0	0	0	0	0	1	5477	521	18	4		4	FAM135B	8	139323163	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2728893	139323163	7040859	172	30070											
DENND3	22898	broad.mit.edu	37	chr8	142188188	142188188	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcactacgtccagcaggCgctgaccaacgtcttgctga	8	8	9	16	3	2	2	1	2	1	0	3	2	3	2	3	1	4	3	3	1	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:142188188C>T	uc003yvy.2	+	16	2767	c.2489C>T	c.(2488-2490)GCG>GTG	p.A830V	DENND3_uc010mep.2_Missense_Mutation_p.A791V	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	830										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GTCCAGCAGGCGCTGACCAAC	0.517													14	45					0	0	0	0	T	142188188	T	T	142188188	3	4	164	1	0	0	0	0	1	0	0	0	4454	768	27	1	2547	1	DENND3	8	142188188	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2865025	142188188	4175834	173	30071											
CYP11B2	1585	broad.mit.edu	37	chr8	143994781	143994781	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttcactgatgctggctgcGgcggccaggctctcctggcg	3	10	15	13	3	2	1	1	1	1	0	3	1	2	1	2	5	2	4	2	5	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr8:143994781G>T	uc003yxk.1	-	6	1044	c.1041C>A	c.(1039-1041)GCC>GCA	p.A347A		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	347					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TGCTGGCTGCGGCGGCCAGGC	0.642									Familial_Hyperaldosteronism_type_I				15	93					3.45872e-05	7.76944e-05	1	0	T	143994781	T	T	143994781	2	4	164	1	0	0	0	0	0	0	0	1	4163	1103	39	3		3	CYP11B2	8	143994781	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1806593	143994781	2369241	174	30072											
IFNA4	3441	broad.mit.edu	37	chr9	21187364	21187364	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggggaatccgaaatcatgtCtgtccttcaggcaggagaaa	12	8	12	9	2	3	1	2	0	1	1	5	4	5	2	2	4	0	1	2	4	3	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr9:21187364C>A	uc003zon.2	-	1	235	c.167G>T	c.(166-168)AGA>ATA	p.R56I		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	56					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GAAATCATGTCTGTCCTTCAG	0.522													98	140					5.34484e-38	1.64424e-37	1	0	A	21187364	A	A	21187364	3	1	164	1	0	0	0	0	1	0	0	0	7578	913	32	2	406	2	IFNA4	9	21187364	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08		21187364	120026067	175	30073											
RECK	8434	broad.mit.edu	37	chr9	36083451	36083451	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaacagactcttctcctggtCcatctcagataaaagcagtg	12	10	8	11	0	3	2	1	0	3	2	6	3	4	2	2	1	2	1	2	1	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr9:36083451C>T	uc003zyv.2	+	8	615	c.529C>T	c.(529-531)CCA>TCA	p.P177S	RECK_uc010mld.2_Missense_Mutation_p.P177S|RECK_uc003zyu.3_Missense_Mutation_p.P177S|RECK_uc003zyw.2_Missense_Mutation_p.P49S|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	177	5 X Knot repeats.|Knot 3.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			TTCTCCTGGTCCATCTCAGAT	0.408													15	89					0	0	0	0	T	36083451	T	T	36083451	3	4	164	1	0	0	0	0	1	0	0	0	13265	855	30	2	559	2	RECK	9	36083451	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	14896087	36083451	105129980	176	30074											
FBXO10	26267	broad.mit.edu	37	chr9	37518331	37518331	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgttgttggccactcgggTgggttggctgctctgggcca	2	12	17	10	1	1	0	0	0	1	0	2	0	1	0	2	5	1	6	2	5	0	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr9:37518331T>A	uc004aab.2	-	9	2354	c.2305A>T	c.(2305-2307)ACC>TCC	p.T769S	FBXO10_uc004aac.2_Missense_Mutation_p.T785S|FBXO10_uc004aad.2_Missense_Mutation_p.T319S	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	769	PbH1 15.					ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		GCCACTCGGGTGGGTTGGCTG	0.567													23	24					0	0	0	0	A	37518331	A	A	37518331	3	1	164	1	0	0	0	0	1	0	0	0	5758	1696	59	5	577	5	FBXO10	9	37518331	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	1434880	37518331	103695100	177	30075											
DCAF10	79269	broad.mit.edu	37	chr9	37860055	37860055	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatatctcaggagtttcaccAcgaaatagtcttgaagtcgt	12	13	8	8	2	3	1	2	1	2	0	5	3	3	2	1	1	0	1	1	1	5	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr9:37860055A>G	uc004aao.2	+	6	1250	c.1176A>G	c.(1174-1176)CCA>CCG	p.P392P	DCAF10_uc010mlz.2_Silent_p.P219P|DCAF10_uc004aap.2_Silent_p.P43P	NM_024345	NP_077321	Q5QP82	DCA10_HUMAN	WD repeat domain 32	392						CUL4 RING ubiquitin ligase complex				central_nervous_system(1)	1						GAGTTTCACCACGAAATAGTC	0.448													4	77					0	0	0	0	G	37860055	G	G	37860055	2	3	164	1	0	0	0	0	0	0	0	1	4278	146	6	5		5	DCAF10	9	37860055	Silent	SNP	A	TCGA-CR-7399-01A-11D-2012-08	341724	37860055	103353376	178	30076											
TRPM3	80036	broad.mit.edu	37	chr9	73151901	73151901	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgggaactagtagcccggtgTaggctcagggacctttcttt	7	12	13	9	1	2	0	1	0	1	0	2	2	2	2	2	4	2	3	2	4	4	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr9:73151901T>A	uc004aid.2	-	25	4336	c.4092A>T	c.(4090-4092)CTA>CTT	p.L1364L	TRPM3_uc004ahu.2_Silent_p.L1206L|TRPM3_uc004ahv.2_Silent_p.L1166L|TRPM3_uc004ahw.2_Silent_p.L1236L|TRPM3_uc004ahx.2_Silent_p.L1223L|TRPM3_uc004ahy.2_Silent_p.L1226L|TRPM3_uc004ahz.2_Silent_p.L1213L|TRPM3_uc004aia.2_Silent_p.L1211L|TRPM3_uc004aib.2_Silent_p.L1201L|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1389	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TAGCCCGGTGTAGGCTCAGGG	0.463													36	114					0	0	0	0	A	73151901	A	A	73151901	2	1	164	1	0	0	0	0	0	0	0	1	16654	1625	57	5		5	TRPM3	9	73151901	Silent	SNP	T	TCGA-CR-7399-01A-11D-2012-08	35291846	73151901	68061530	179	30077											
PAPPA	5069	broad.mit.edu	37	chr9	118973930	118973930	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttacaggtggcattgtctTgaacccatctttctatggca	8	14	8	11	0	3	1	0	1	3	0	3	1	3	1	2	3	2	2	2	3	3	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr9:118973930T>A	uc004bjn.2	+	4	2018	c.1637T>A	c.(1636-1638)TTG>TAG	p.L546*	PAPPA_uc011lxp.1_Intron|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	546	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GGCATTGTCTTGAACCCATCT	0.502													22	64					0	0	0	0	A	118973930	A	A	118973930	4	1	164	1	0	0	0	0	0	1	0	0	11486	1821	63	5	1651	5	PAPPA	9	118973930	Nonsense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	45822029	118973930	22239501	180	30078											
OR1L3	26735	broad.mit.edu	37	chr9	125438052	125438052	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctccatttgtctgtatcaTcatctcttatctaagaattc	9	17	5	10	0	5	1	2	0	3	1	8	1	6	1	1	1	0	2	1	1	4	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr9:125438052T>C	uc011lzb.1	+	1	644	c.644T>C	c.(643-645)ATC>ACC	p.I215T		NM_001005234	NP_001005234	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GTCTGTATCATCATCTCTTAT	0.488													22	91					0	0	0	0	C	125438052	C	C	125438052	3	2	164	1	0	0	0	0	1	0	0	0	11018	1435	50	5	646	5	OR1L3	9	125438052	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	6464122	125438052	15775379	181	30079											
GDI2	2665	broad.mit.edu	37	chr10	5836966	5836966	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttacctctgtataaagcagCatcttaaccagctgacctag	12	11	7	11	0	2	1	0	1	2	0	2	1	2	1	3	0	5	5	3	0	6	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:5836966C>T	uc001iil.3	-	4	561	c.270G>A	c.(268-270)ATG>ATA	p.M90I	GDI2_uc001iim.3_Intron|GDI2_uc009xid.2_Missense_Mutation_p.M94I	NM_001494	NP_001485	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2 isoform 1	90					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity				0						TATAAAGCAGCATCTTAACCA	0.333													27	37					0	0	0	0	T	5836966	T	T	5836966	3	4	164	1	0	0	0	0	1	0	0	0	6358	710	25	4	1099	4	GDI2	10	5836966	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08		5836966	129697781	182	30080											
GATA3	2625	broad.mit.edu	37	chr10	8100316	8100316	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatggatccctaccctggcTggacggcggcaaagccctgg	7	7	13	14	2	1	0	1	0	0	0	2	2	2	2	3	6	2	2	3	6	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:8100316T>A	uc001ika.2	+	3	847	c.290T>A	c.(289-291)CTG>CAG	p.L97Q	GATA3_uc001ijz.2_Missense_Mutation_p.L97Q	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	97					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						CTACCCTGGCTGGACGGCGGC	0.687			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						15	98					0	0	0	0	A	8100316	A	A	8100316	3	1	164	1	0	0	0	0	1	0	0	0	6290	1580	55	5	296	5	GATA3	10	8100316	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	2263350	8100316	127434431	183	30081											
MBL2	4153	broad.mit.edu	37	chr10	54529051	54529051	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgcagagcttttctttctGaggcagccaggctactatca	8	14	9	10	0	3	2	1	1	2	1	3	2	3	2	1	2	4	4	1	2	2	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:54529051G>C	uc001jjt.2	-	3	394	c.329C>G	c.(328-330)TCA>TGA	p.S110*		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	110					acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						TTTTCTTTCTGAGGCAGCCAG	0.408													19	106					0	0	0	0	C	54529051	C	C	54529051	4	2	164	1	0	0	0	0	0	1	0	0	9403	1294	45	2	425	2	MBL2	10	54529051	Nonsense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	46428735	54529051	81005696	184	30082											
RTKN2	219790	broad.mit.edu	37	chr10	63957982	63957982	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtttatcagaaggaggaagGggagcttgtctctttttccc	9	13	12	7	0	2	1	1	0	1	1	4	4	3	4	1	4	1	2	1	4	3	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:63957982G>A	uc001jlw.2	-	12	1612	c.1515C>T	c.(1513-1515)CCC>CCT	p.P505P	RTKN2_uc009xpf.1_Intron|RTKN2_uc001jlv.2_Silent_p.P159P	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	505					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					AAGGAGGAAGGGGAGCTTGTC	0.398													29	123					0	0	0	0	A	63957982	A	A	63957982	2	1	164	1	0	0	0	0	0	0	0	1	13788	1219	43	4		4	RTKN2	10	63957982	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	9428931	63957982	71576765	185	30083											
CTNNA3	29119	broad.mit.edu	37	chr10	67726465	67726465	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagaacttaatctgttccaGgtaggccaacaagtcctgtt	11	12	9	9	0	1	1	0	0	1	1	3	1	3	1	3	2	2	4	3	2	6	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:67726465G>A	uc009xpn.1	-	17	2428	c.2305C>T	c.(2305-2307)CTG>TTG	p.L769L	CTNNA3_uc001jmw.2_Silent_p.L769L	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	769					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						ATCTGTTCCAGGTAGGCCAAC	0.403													12	46					0	0	0	0	A	67726465	A	A	67726465	2	1	164	1	0	0	0	0	0	0	0	1	4031	991	35	4		4	CTNNA3	10	67726465	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3768483	67726465	67808282	186	30084											
KIAA0913	23053	broad.mit.edu	37	chr10	75560118	75560118	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcactgcctgccctgacCacacagcccagccctctggt	6	7	8	20	0	2	1	1	1	1	0	2	1	2	1	6	1	4	0	6	1	0	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:75560118C>G	uc009xrl.2	+	23	4931	c.4899C>G	c.(4897-4899)ACC>ACG	p.T1633T	KIAA0913_uc001jve.2_Silent_p.T1638T|KIAA0913_uc001jvf.2_Silent_p.T1451T|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Silent_p.T1060T|KIAA0913_uc010qkr.1_Silent_p.T1048T|KIAA0913_uc001jvj.2_Silent_p.T1048T|KIAA0913_uc009xrn.1_Silent_p.T44T	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	1633	Pro-rich.						zinc ion binding			breast(1)	1	Prostate(51;0.0112)					CTGCCCTGACCACACAGCCCA	0.607													17	76					0	0	0	0	G	75560118	G	G	75560118	2	3	164	1	0	0	0	0	0	0	0	1	8239	581	21	4		4	KIAA0913	10	75560118	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	7833653	75560118	59974629	187	30085											
LRIT1	26103	broad.mit.edu	37	chr10	85992040	85992040	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ataacacactgctccttccgGggcaccaggccctgcacaca	10	6	8	17	1	0	0	0	0	0	0	2	0	2	0	4	3	3	3	4	3	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:85992040G>T	uc001kcz.1	-	4	1537	c.1515C>A	c.(1513-1515)CCC>CCA	p.P505P		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	505	Fibronectin type-III.|Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						GCTCCTTCCGGGGCACCAGGC	0.552													6	15					8.12818e-05	0.000179429	1	0	T	85992040	T	T	85992040	2	4	164	1	0	0	0	0	0	0	0	1	8997	1219	43	4		4	LRIT1	10	85992040	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	10431922	85992040	49542707	188	30086											
FAM190B	54462	broad.mit.edu	37	chr10	86133458	86133458	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagctggttcttcgtttgaaCtctctccatctgatagctct	6	16	8	11	1	4	2	0	2	4	0	7	3	5	2	1	1	3	4	1	1	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:86133458C>T	uc001kdh.1	+	3	1695	c.1501C>T	c.(1501-1503)CTC>TTC	p.L501F	FAM190B_uc001kdg.1_Missense_Mutation_p.L501F|FAM190B_uc010qmd.1_Missense_Mutation_p.L501F	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	501										ovary(3)|skin(1)	4						TTCGTTTGAACTCTCTCCATC	0.428													6	27					0	0	0	0	T	86133458	T	T	86133458	3	4	164	1	0	0	0	0	1	0	0	0	5550	565	20	4	1507	4	FAM190B	10	86133458	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	141418	86133458	49401289	189	30087											
PLCE1	51196	broad.mit.edu	37	chr10	96064340	96064340	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaagaactgccccatgtatCagaagttttctccactagaa	14	10	6	11	0	2	3	1	0	1	3	3	3	2	3	3	0	2	2	3	0	6	4	rs121912604		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:96064340C>T	uc001kjk.2	+	25	6194	c.5560C>T	c.(5560-5562)CAG>TAG	p.Q1854*	PLCE1_uc010qnx.1_Nonsense_Mutation_p.Q1838*|PLCE1_uc001kjm.2_Nonsense_Mutation_p.Q1546*|PLCE1_uc001kjp.2_Nonsense_Mutation_p.Q212*	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1854					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				CCCCATGTATCAGAAGTTTTC	0.433													18	80					0	0	0	0	T	96064340	T	T	96064340	4	4	164	1	0	0	0	0	0	1	0	0	12089	827	29	2	5940	2	PLCE1	10	96064340	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	9930882	96064340	39470407	190	30088											
C10orf76	79591	broad.mit.edu	37	chr10	103771498	103771498	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accatatttgttaaagcagaGaaaaaaccactttggtgttc	15	12	7	7	0	0	1	0	0	0	1	1	2	0	1	2	1	2	3	2	1	6	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:103771498G>C	uc009xwy.1	-	11	915	c.813C>G	c.(811-813)TTC>TTG	p.F271L		NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	271						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		TTAAAGCAGAGAAAAAACCAC	0.358													8	32					0	0	0	0	C	103771498	C	C	103771498	3	2	164	1	0	0	0	0	1	0	0	0	1622	933	33	2	1320	2	C10orf76	10	103771498	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	7707158	103771498	31763249	191	30089											
COL17A1	1308	broad.mit.edu	37	chr10	105793987	105793987	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgtgtgaggaggagctgctaCcccgactgtgggaggcatcc	7	8	16	10	1	0	1	0	1	0	0	1	5	1	4	3	4	3	3	3	4	1	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:105793987C>T	uc001kxr.2	-	52	4041	c.3872G>A	c.(3871-3873)GGT>GAT	p.G1291D	COL17A1_uc001kxq.2_5'Flank	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1291	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGAGCTGCTACCCCGACTGTG	0.672													4	21					0	0	0	0	T	105793987	T	T	105793987	3	4	164	1	0	0	0	0	1	0	0	0	3689	507	18	4	641	4	COL17A1	10	105793987	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2022489	105793987	29740760	192	30090											
SORCS1	114815	broad.mit.edu	37	chr10	108377909	108377909	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgagatgggcactcaccaTatactgcgatggtctttgtg	9	12	11	9	1	2	1	1	1	1	1	2	3	2	1	1	2	2	1	1	2	2	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:108377909T>A	uc001kym.2	-	21	2926	c.2918A>T	c.(2917-2919)TAT>TTT	p.Y973F	SORCS1_uc001kyl.2_Missense_Mutation_p.Y973F|SORCS1_uc009xxs.2_Missense_Mutation_p.Y973F|SORCS1_uc001kyn.1_Missense_Mutation_p.Y973F|SORCS1_uc001kyo.2_Missense_Mutation_p.Y973F	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	973	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GCACTCACCATATACTGCGAT	0.478													13	61					0	0	0	0	A	108377909	A	A	108377909	3	1	164	1	0	0	0	0	1	0	0	0	14994	1406	49	5	846	5	SORCS1	10	108377909	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	2583922	108377909	27156838	193	30091											
KNDC1	85442	broad.mit.edu	37	chr10	135012615	135012615	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtgtcccagagaggccgcGgcccgcagaccggaggctct	7	4	15	15	4	1	2	0	0	1	2	2	4	2	3	4	4	0	2	4	4	0	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:135012615G>T	uc001llz.1	+	14	2604	c.2603G>T	c.(2602-2604)CGG>CTG	p.R868L	KNDC1_uc001lma.1_Missense_Mutation_p.R803L|KNDC1_uc001lmb.1_Missense_Mutation_p.R280L	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	868	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GAGAGGCCGCGGCCCGCAGAC	0.731													4	12					0.00024832	0.000537325	1	0	T	135012615	T	T	135012615	3	4	164	1	0	0	0	0	1	0	0	0	8465	1116	39	3	2657	3	KNDC1	10	135012615	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	26634706	135012615	522132	194	30092											
FRG2B	441581	broad.mit.edu	37	chr10	135440300	135440300	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acgtccaaaggcagagtgtgGgttagtctgctagacctgcc	9	9	13	10	1	1	2	0	0	1	2	2	2	2	2	3	2	2	3	3	2	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr10:135440300G>C	uc010qvg.1	-	1	1	c.-52_splice	c.e1-1			NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B							nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GCAGAGTGTGGGTTAGTCTGC	0.522													4	28					0	0	0	0	C	135440300	C	C	135440300	5	2	164	1	0	0	0	0	0	0	1	0	6081	1247	43	4		4	FRG2B	10	135440300	Splice_Site	SNP	G	TCGA-CR-7399-01A-11D-2012-08	427685	135440300	94447	195	30093											
OR51G1	79324	broad.mit.edu	37	chr11	4945221	4945221	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcaatggacatggataacaGaactgatgactccattgaag	15	9	10	7	0	1	4	1	3	0	1	2	6	2	6	1	2	2	0	1	2	4	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:4945221G>A	uc010qyr.1	-	1	349	c.349C>T	c.(349-351)CTG>TTG	p.L117L		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGGATAACAGAACTGATGAC	0.507													10	30					0	0	0	0	A	4945221	A	A	4945221	2	1	164	1	0	0	0	0	0	0	0	1	11152	933	33	2		2	OR51G1	11	4945221	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08		4945221	130061295	196	30094											
OR51I2	390064	broad.mit.edu	37	chr11	5474807	5474807	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcactcctggctgtcagggcCcctctgcgtgatgtatgctg	4	12	12	13	1	3	1	2	1	1	0	4	1	4	1	3	2	2	3	3	2	1	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:5474807C>A	uc010qzf.1	+	1	89	c.89C>A	c.(88-90)CCC>CAC	p.P30H	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGTCAGGGCCCCTCTGCGTG	0.557													19	29					2.35188e-11	6.41118e-11	1	0	A	5474807	A	A	5474807	3	1	164	1	0	0	0	0	1	0	0	0	11155	623	22	4	91	4	OR51I2	11	5474807	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	529586	5474807	129531709	197	30095											
TRIM5	85363	broad.mit.edu	37	chr11	5701005	5701005	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttacttggtactcccgggCaacctcctctgtgaggaacg	7	11	10	13	2	2	1	0	1	2	0	4	2	4	2	3	3	4	2	3	3	4	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:5701005C>A	uc001mbm.1	-	2	660	c.403G>T	c.(403-405)GCC>TCC	p.A135S	TRIM5_uc001mbq.1_Missense_Mutation_p.A135S|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Missense_Mutation_p.A135S|TRIM5_uc001mbo.2_Missense_Mutation_p.A135S|TRIM5_uc001mbp.2_Missense_Mutation_p.A135S	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	135	Potential.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		TACTCCCGGGCAACCTCCTCT	0.512													11	53					6.40141e-05	0.000141719	1	0	A	5701005	A	A	5701005	3	1	164	1	0	0	0	0	1	0	0	0	16592	710	25	4	1345	4	TRIM5	11	5701005	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	226198	5701005	129305511	198	30096											
OR52N1	79473	broad.mit.edu	37	chr11	5809561	5809561	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaaggcgcttggtgaggaaAgtggaagggataacaagcat	14	6	17	4	1	0	1	0	1	0	0	0	5	0	5	0	6	2	2	0	6	5	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:5809561A>C	uc010qzo.1	-	1	486	c.486T>G	c.(484-486)ACT>ACG	p.T162T	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	162	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		TGGTGAGGAAAGTGGAAGGGA	0.498													10	33					0	0	0	0	C	5809561	C	C	5809561	2	2	164	1	0	0	0	0	0	0	0	1	11181	59	3	5		5	OR52N1	11	5809561	Silent	SNP	A	TCGA-CR-7399-01A-11D-2012-08	108556	5809561	129196955	199	30097											
OR56A1	120796	broad.mit.edu	37	chr11	6048932	6048932	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgacgccataggctgaatCatgagctgagtaggcttctg	9	10	14	8	1	2	4	1	4	1	0	2	4	2	4	1	3	1	4	1	3	3	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:6048932C>A	uc010qzw.1	-	1	3	c.3G>T	c.(1-3)ATG>ATT	p.M1I		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGGCTGAATCATGAGCTGAG	0.458													31	86					8.16721e-17	2.35191e-16	1	0	A	6048932	A	A	6048932	3	1	164	1	0	0	0	0	1	0	0	0	11187	826	29	2	957	2	OR56A1	11	6048932	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	239371	6048932	128957584	200	30098											
ABCC8	6833	broad.mit.edu	37	chr11	17426158	17426158	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacataggagatgacggccAgggctgagacacagagcagg	13	4	16	8	1	0	5	0	3	0	3	0	7	0	5	1	4	1	2	1	4	1	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:17426158A>T	uc001mnc.2	-	28	3584	c.3458T>A	c.(3457-3459)CTG>CAG	p.L1153Q		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1153	Helical; Name=14; (By similarity).|ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GATGACGGCCAGGGCTGAGAC	0.597													8	12					0	0	0	0	T	17426158	T	T	17426158	3	4	164	1	0	0	0	0	1	0	0	0	58	188	7	5	1335	5	ABCC8	11	17426158	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	11377226	17426158	117580358	201	30099											
SLC17A6	57084	broad.mit.edu	37	chr11	22396420	22396420	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actacgacagtgagaaagatCatgaattgtggtggtaagta	15	10	12	4	1	1	3	1	2	0	2	1	5	1	3	0	2	1	2	0	2	5	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:22396420C>A	uc001mqk.2	+	9	1574	c.1161C>A	c.(1159-1161)ATC>ATA	p.I387I		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	387	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TGAGAAAGATCATGAATTGTG	0.353													24	85					1.85244e-09	4.81007e-09	1	0	A	22396420	A	A	22396420	2	1	164	1	0	0	0	0	0	0	0	1	14486	816	29	2		2	SLC17A6	11	22396420	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	4970262	22396420	112610096	202	30100											
OR4A5	81318	broad.mit.edu	37	chr11	51411502	51411502	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atagttaactttttacccaaGagtttttctatagcatttct	11	19	4	7	0	2	1	0	0	2	1	2	1	2	1	1	0	3	3	1	0	6	10			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:51411502G>C	uc001nhi.1	-	1	894	c.894C>G	c.(892-894)CTC>CTG	p.L298L		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				TTTTACCCAAGAGTTTTTCTA	0.353													4	10					0	0	0	0	C	51411502	C	C	51411502	2	2	164	1	0	0	0	0	0	0	0	1	11097	929	33	2		2	OR4A5	11	51411502	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	29015082	51411502	83595014	203	30101											
OR5D14	219436	broad.mit.edu	37	chr11	55563722	55563722	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgactgtactaaaaatcCgttctgttagtgggcgccac	9	13	10	9	2	1	1	0	1	1	0	2	1	2	1	2	1	1	3	2	1	5	5	rs143761060		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:55563722C>A	uc010rim.1	+	1	691	c.691C>A	c.(691-693)CGT>AGT	p.R231S		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				ACTAAAAATCCGTTCTGTTAG	0.473													15	81					3.45872e-05	7.76944e-05	1	0	A	55563722	A	A	55563722	3	1	164	1	0	0	0	0	1	0	0	0	11209	652	23	3	693	3	OR5D14	11	55563722	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	4152220	55563722	79442794	204	30102											
OR5L1	219437	broad.mit.edu	37	chr11	55579653	55579653	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagagggcaggcacaaagcCttctccacctgtgcttccca	9	7	10	15	0	1	1	0	0	1	1	3	1	2	1	4	2	2	4	4	2	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:55579653C>T	uc001nhw.1	+	1	711	c.711C>T	c.(709-711)GCC>GCT	p.A237A		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				GGCACAAAGCCTTCTCCACCT	0.502													23	68					0	0	0	0	T	55579653	T	T	55579653	2	4	164	1	0	0	0	0	0	0	0	1	11224	668	24	4		4	OR5L1	11	55579653	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	15931	55579653	79426863	205	30103											
OR5AR1	219493	broad.mit.edu	37	chr11	56432020	56432020	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttatcatccccatgttaaatCccttgatctacagtttgcgg	9	15	6	11	1	2	1	1	1	1	0	4	1	4	1	3	1	2	2	3	1	4	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:56432020C>A	uc010rjm.1	+	1	859	c.859C>A	c.(859-861)CCC>ACC	p.P287T		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATGTTAAATCCCTTGATCTA	0.408													10	38					2.17888e-05	4.92336e-05	1	0	A	56432020	A	A	56432020	3	1	164	1	0	0	0	0	1	0	0	0	11199	855	30	2	861	2	OR5AR1	11	56432020	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	852367	56432020	78574496	206	30104											
OR5B17	219965	broad.mit.edu	37	chr11	58126434	58126434	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccccaggttcccagtcaGagtgatgaggtagatgaggg	10	8	14	9	0	1	5	1	3	0	2	3	5	3	5	3	3	0	2	3	3	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:58126434G>T	uc010rke.1	-	1	109	c.109C>A	c.(109-111)CTG>ATG	p.L37M		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TTCCCAGTCAGAGTGATGAGG	0.458													10	61					0.000442599	0.000939144	1	0	T	58126434	T	T	58126434	3	4	164	1	0	0	0	0	1	0	0	0	11203	933	33	2	837	2	OR5B17	11	58126434	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1694414	58126434	76880082	207	30105											
OR4D10	390197	broad.mit.edu	37	chr11	59245729	59245729	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccatctctgtcaccttcaCtgtcatctcccctctgctca	5	13	5	18	0	7	0	4	0	3	0	9	0	7	0	4	1	1	1	4	1	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:59245729C>A	uc001nnz.1	+	1	827	c.827C>A	c.(826-828)ACT>AAT	p.T276N		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GTCACCTTCACTGTCATCTCC	0.527													28	113					2.61193e-14	7.3828e-14	1	0	A	59245729	A	A	59245729	3	1	164	1	0	0	0	0	1	0	0	0	11108	565	20	4	829	4	OR4D10	11	59245729	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1119295	59245729	75760787	208	30106											
FEN1	2237	broad.mit.edu	37	chr11	61563897	61563897	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcactctcttcagctaagcGcaaggagccagaacccaagg	12	6	9	14	1	3	1	2	0	1	1	4	2	3	2	2	2	4	2	2	2	4	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:61563897G>T	uc001nsg.2	+	2	1436	c.1064G>T	c.(1063-1065)CGC>CTC	p.R355L		NM_004111	NP_004102	P39748	FEN1_HUMAN	flap structure-specific endonuclease 1	355					base-excision repair|DNA replication, removal of RNA primer|double-strand break repair|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|UV protection	mitochondrion|nucleolus|nucleoplasm	5'-3' exonuclease activity|5'-flap endonuclease activity|damaged DNA binding|double-stranded DNA binding|double-stranded DNA specific exodeoxyribonuclease activity|metal ion binding|protein binding|ribonuclease H activity			ovary(1)	1						TCAGCTAAGCGCAAGGAGCCA	0.532								Direct_reversal_of_damage|Editing_and_processing_nucleases					5	20					0.000602214	0.0012673	1	0	T	61563897	T	T	61563897	3	4	164	1	0	0	0	0	1	0	0	0	5844	1087	38	3	1066	3	FEN1	11	61563897	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2318168	61563897	73442619	209	30107											
PACS1	55690	broad.mit.edu	37	chr11	65995047	65995047	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacagcttgactgaaacaGacactctggtatgtatgggt	12	11	11	7	0	1	4	0	3	1	1	1	4	1	4	0	2	2	3	0	2	3	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:65995047G>T	uc001oha.1	+	11	1500	c.1366G>T	c.(1366-1368)GAC>TAC	p.D456Y	PACS1_uc010rou.1_5'Flank	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	456					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						GACTGAAACAGACACTCTGGT	0.373													5	23					1.23904e-05	2.82472e-05	1	0	T	65995047	T	T	65995047	3	4	164	1	0	0	0	0	1	0	0	0	11426	942	33	2	1408	2	PACS1	11	65995047	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	4431150	65995047	69011469	210	30108											
NDUFS8	4728	broad.mit.edu	37	chr11	67803822	67803822	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	actgcggcttctgccaggagGcctgtcccgtggatgccatc	5	9	13	14	2	1	0	0	0	1	0	3	2	2	2	4	4	3	1	4	4	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:67803822G>C	uc001onc.2	+	6	582	c.475G>C	c.(475-477)GCC>CCC	p.A159P	NDUFS8_uc009ysb.1_RNA|NDUFS8_uc009ysc.1_Missense_Mutation_p.A159P|TCIRG1_uc001ond.1_5'Flank|TCIRG1_uc001one.2_5'Flank	NM_002496	NP_002487	O00217	NDUS8_HUMAN	NADH dehydrogenase ubiquinone Fe-S 8 precursor	159	4Fe-4S ferredoxin-type 2.				mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)	CTGCCAGGAGGCCTGTCCCGT	0.652													7	35					0	0	0	0	C	67803822	C	C	67803822	3	2	164	1	0	0	0	0	1	0	0	0	10352	1203	42	4	493	4	NDUFS8	11	67803822	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1808775	67803822	67202694	211	30109											
KRTAP5-7	440050	broad.mit.edu	37	chr11	71238392	71238393	+	Missense_Mutation	DNP	GG	AT	AT																															gctgtggctccggctgtgggGgctgtggctccggctgtggg																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:71238392_71238393GG>AT	uc001oqq.1	+	1	80_81	c.46_47GG>AT	c.(46-48)GGC>ATC	p.G16I		NM_001012503	NP_001012521	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	16						keratin filament					0						CGGCTGTGGGGGCTGTGGCTCC	0.658													345	193					0	0	0	0	AT	71238393	AT	AT	71238392	3	1	164	1	0	0	0	0	1	0	0	0	8606	1232	43	4	48	4	KRTAP5-7	11	71238392	Missense_Mutation	DNP	GG	TCGA-CR-7399-01A-11D-2012-08	3434570	71238392	63768124	212	30110											
MMP8	4317	broad.mit.edu	37	chr11	102595499	102595499	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttacctgaacagtttttgTatttttctctttagaagata	11	20	5	5	0	1	3	0	1	1	2	2	3	1	3	1	0	2	2	1	0	6	10			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:102595499T>C	uc001phe.2	-	1	187	c.88A>G	c.(88-90)ACA>GCA	p.T30A	MMP8_uc010rut.1_5'Flank|MMP8_uc010ruu.1_Translation_Start_Site	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	30					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		ACAGTTTTTGTATTTTTCTCT	0.363													39	116					0	0	0	0	C	102595499	C	C	102595499	3	2	164	1	0	0	0	0	1	0	0	0	9721	1638	57	5	1355	5	MMP8	11	102595499	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	31357107	102595499	32411017	213	30111											
GRAMD1B	57476	broad.mit.edu	37	chr11	123480966	123480966	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgccgaagtcctcacccaCgacgtgccctaccatgacta	10	7	8	16	3	1	1	1	1	0	0	2	4	2	1	5	0	3	0	5	0	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:123480966C>T	uc001pyx.2	+	13	1739	c.1410C>T	c.(1408-1410)CAC>CAT	p.H470H	GRAMD1B_uc001pyw.2_Silent_p.H477H|GRAMD1B_uc010rzw.1_Silent_p.H430H|GRAMD1B_uc010rzx.1_Silent_p.H430H|GRAMD1B_uc001pyy.2_Silent_p.H161H	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	470						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		TCCTCACCCACGACGTGCCCT	0.542													17	46					0	0	0	0	T	123480966	T	T	123480966	2	4	164	1	0	0	0	0	0	0	0	1	6787	535	19	1		1	GRAMD1B	11	123480966	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	20885467	123480966	11525550	214	30112											
OR8B3	390271	broad.mit.edu	37	chr11	124266426	124266426	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacattagtgtagaaaacAgaagaaacttttccctgctc	15	10	6	10	0	0	3	0	0	0	3	2	3	1	3	2	0	3	2	2	0	6	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:124266426A>T	uc010saj.1	-	1	822	c.822T>A	c.(820-822)TCT>TCA	p.S274S	OR8B2_uc001qab.3_Intron	NM_001005467	NP_001005467	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TGTAGAAAACAGAAGAAACTT	0.403													16	65					0	0	0	0	T	124266426	T	T	124266426	2	4	164	1	0	0	0	0	0	0	0	1	11282	175	7	5		5	OR8B3	11	124266426	Silent	SNP	A	TCGA-CR-7399-01A-11D-2012-08	785460	124266426	10740090	215	30113											
ADAMTS8	11095	broad.mit.edu	37	chr11	130286106	130286106	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atacatggcgctgcagggggAccagggcagcgtctggttca	8	7	16	10	2	2	0	1	0	1	0	2	1	2	1	1	5	3	4	1	5	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr11:130286106A>G	uc001qgg.3	-	4	1574	c.1216T>C	c.(1216-1218)TCC>CCC	p.S406P		NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	406	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CTGCAGGGGGACCAGGGCAGC	0.677													2	4					0	0	0	0	G	130286106	G	G	130286106	3	3	164	1	0	0	0	0	1	0	0	0	272	275	10	5	1477	5	ADAMTS8	11	130286106	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	6019680	130286106	4720410	216	30114											
CACNA1C	775	broad.mit.edu	37	chr12	2690864	2690864	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcatcatcttctccctcctGgggatgcagctctttggagg	6	13	10	12	0	5	0	2	0	3	0	7	2	6	2	2	4	2	2	2	4	0	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:2690864G>T	uc009zdu.1	+	14	2317	c.2004G>T	c.(2002-2004)CTG>CTT	p.L668L	CACNA1C_uc009zdv.1_Silent_p.L665L|CACNA1C_uc001qkb.2_Silent_p.L668L|CACNA1C_uc001qkc.2_Silent_p.L668L|CACNA1C_uc001qke.2_Silent_p.L668L|CACNA1C_uc001qkf.2_Silent_p.L668L|CACNA1C_uc001qjz.2_Silent_p.L668L|CACNA1C_uc001qkd.2_Silent_p.L668L|CACNA1C_uc001qkg.2_Silent_p.L668L|CACNA1C_uc009zdw.1_Silent_p.L668L|CACNA1C_uc001qkh.2_Silent_p.L668L|CACNA1C_uc001qkl.2_Silent_p.L668L|CACNA1C_uc001qkn.2_Silent_p.L668L|CACNA1C_uc001qko.2_Silent_p.L668L|CACNA1C_uc001qkp.2_Silent_p.L668L|CACNA1C_uc001qkr.2_Silent_p.L668L|CACNA1C_uc001qku.2_Silent_p.L668L|CACNA1C_uc001qkq.2_Silent_p.L668L|CACNA1C_uc001qks.2_Silent_p.L668L|CACNA1C_uc001qkt.2_Silent_p.L668L|CACNA1C_uc001qka.1_Silent_p.L203L|CACNA1C_uc001qki.1_Silent_p.L404L|CACNA1C_uc001qkj.1_Silent_p.L404L|CACNA1C_uc001qkk.1_Silent_p.L404L|CACNA1C_uc001qkm.1_Silent_p.L404L|CACNA1C_uc001qkw.2_5'Flank	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	668	II.|Helical; Name=S5 of repeat II; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	tctccctcctGGGGATGCAGC	0.423													4	29					0.00024832	0.000537325	1	0	T	2690864	T	T	2690864	2	4	164	1	0	0	0	0	0	0	0	1	2552	1335	47	4		4	CACNA1C	12	2690864	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08		2690864	131161031	217	30115											
FOXJ2	55810	broad.mit.edu	37	chr12	8196611	8196611	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggaggcgttgcagggagtgGagaagcctcactgcctcctg	7	7	17	10	1	1	1	1	0	0	1	2	4	2	3	3	4	3	2	3	4	1	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:8196611G>T	uc001qtu.2	+	5	1627	c.542G>T	c.(541-543)GGA>GTA	p.G181V	FOXJ2_uc001qtt.1_Missense_Mutation_p.G181V	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	181					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				Kidney(36;0.0944)		GCAGGGAGTGGAGAAGCCTCA	0.542													20	89					7.21436e-19	2.10924e-18	1	0	T	8196611	T	T	8196611	3	4	164	1	0	0	0	0	1	0	0	0	6046	1174	41	2	556	2	FOXJ2	12	8196611	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	5505747	8196611	125655284	218	30116											
GRIN2B	2904	broad.mit.edu	37	chr12	13716163	13716163	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacatctcaaacatgtgggCgtaggggctcccatccatga	10	9	11	11	1	1	2	1	2	1	0	4	2	3	2	2	3	1	2	2	3	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:13716163C>G	uc001rbt.2	-	13	4188	c.4009G>C	c.(4009-4011)GCC>CCC	p.A1337P		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1337	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AACATGTGGGCGTAGGGGCTC	0.612													28	67					0	0	0	0	G	13716163	G	G	13716163	3	3	164	1	0	0	0	0	1	0	0	0	6819	768	27	3	449	3	GRIN2B	12	13716163	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	5519552	13716163	120135732	219	30117											
SLCO1B3	28234	broad.mit.edu	37	chr12	20968719	20968719	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacagcagagtcagcatcttCagagaaaaagaaaacaagac	21	4	8	8	0	3	4	2	0	1	4	3	5	3	4	0	0	4	2	0	0	6	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:20968719C>G	uc001rek.2	+	2	173	c.47C>G	c.(46-48)TCA>TGA	p.S16*	SLCO1B3_uc001rel.2_Nonsense_Mutation_p.S16*|SLCO1B3_uc010sil.1_Nonsense_Mutation_p.S16*|LST-3TM12_uc010sim.1_Nonsense_Mutation_p.S16*	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	16	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TCAGCATCTTCAGAGAAAAAG	0.299													8	39					0	0	0	0	G	20968719	G	G	20968719	4	3	164	1	0	0	0	0	0	1	0	0	14788	838	29	2	49	2	SLCO1B3	12	20968719	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	7252556	20968719	112883176	220	30118											
LST-3TM12	338821	broad.mit.edu	37	chr12	21196321	21196321	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggttggagcttggtggcttGgtttccttgtgtctggaata	4	16	16	5	0	1	0	0	0	1	0	2	2	2	2	1	6	1	4	1	6	2	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:21196321G>T	uc010sin.1	+	6	640	c.640G>T	c.(640-642)GGT>TGT	p.G214C	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Missense_Mutation_p.G261C	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	214						membrane	transporter activity				0						TTGGTGGCTTGGTTTCCTTGT	0.363													21	139					7.41877e-09	1.88797e-08	1	0	T	21196321	T	T	21196321	3	4	164	1	0	0	0	0	1	0	0	0	9116	1348	47	4	662	4	LST-3TM12	12	21196321	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	227602	21196321	112655574	221	30119											
SOX5	6660	broad.mit.edu	37	chr12	23689547	23689547	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctgcttgctgagacgggCttgctcctcataatatggct	6	13	12	10	1	1	1	1	1	0	1	2	2	2	1	1	2	4	6	1	2	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:23689547C>G	uc001rfw.2	-	14	1930	c.1828G>C	c.(1828-1830)GCC>CCC	p.A610P	SOX5_uc001rfx.2_Missense_Mutation_p.A597P|SOX5_uc001rfy.2_Missense_Mutation_p.A489P|SOX5_uc001rfv.2_Missense_Mutation_p.A224P|SOX5_uc010siv.1_Missense_Mutation_p.A597P|SOX5_uc010siw.1_RNA	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	610	HMG box.				transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						CTGAGACGGGCTTGCTCCTCA	0.493													31	89					0	0	0	0	G	23689547	G	G	23689547	3	3	164	1	0	0	0	0	1	0	0	0	15018	797	28	4	471	4	SOX5	12	23689547	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2493226	23689547	110162348	222	30120											
IPO8	10526	broad.mit.edu	37	chr12	30792543	30792543	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgaattcgttctaaagtatGtagcagcaaatcagggttgt	12	13	10	6	1	2	1	1	1	1	0	3	1	2	1	0	1	2	6	0	1	6	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:30792543G>A	uc001rjd.2	-	21	2565	c.2395C>T	c.(2395-2397)CAT>TAT	p.H799Y	IPO8_uc001rje.1_Missense_Mutation_p.H288Y|IPO8_uc010sjt.1_Missense_Mutation_p.H594Y	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	799					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TCTAAAGTATGTAGCAGCAAA	0.403													25	49					0	0	0	0	A	30792543	A	A	30792543	3	1	164	1	0	0	0	0	1	0	0	0	7837	1377	48	4	738	4	IPO8	12	30792543	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	7102996	30792543	103059352	223	30121											
ACVRL1	94	broad.mit.edu	37	chr12	52309931	52309931	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggacgagcagatccgcaCggactgctttgagtcctaca	9	8	12	12	3	0	2	0	1	0	1	2	5	2	4	2	2	3	4	2	2	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:52309931C>A	uc001rzj.2	+	8	1443	c.1160C>A	c.(1159-1161)ACG>AAG	p.T387K	ACVRL1_uc001rzk.2_Missense_Mutation_p.T387K|ACVRL1_uc010snm.1_Missense_Mutation_p.T213K	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	387	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CAGATCCGCACGGACTGCTTT	0.612									Hereditary_Hemorrhagic_Telangiectasia				11	54					0.000673444	0.00140945	1	0	A	52309931	A	A	52309931	3	1	164	1	0	0	0	0	1	0	0	0	225	536	19	3	1186	3	ACVRL1	12	52309931	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	21517388	52309931	81541964	224	30122											
MARS	4141	broad.mit.edu	37	chr12	57908991	57908991	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagctgccttgctctctgtcAtgcttcagccttacatgccc	5	14	7	15	0	3	0	2	0	1	0	4	0	3	0	3	0	7	3	3	0	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:57908991A>G	uc001sog.2	+	18	2286	c.2263A>G	c.(2263-2265)ATG>GTG	p.M755V	MARS_uc001sof.1_RNA|MARS_uc010srq.1_Missense_Mutation_p.M521V|MARS_uc001soh.1_3'UTR	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	755					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	GCTCTCTGTCATGCTTCAGCC	0.547													44	42					0	0	0	0	G	57908991	G	G	57908991	3	3	164	1	0	0	0	0	1	0	0	0	9369	217	8	5	2333	5	MARS	12	57908991	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	5599060	57908991	75942904	225	30123											
GEFT	115557	broad.mit.edu	37	chr12	58009731	58009731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atgtcctgcaggctgcagacCctgctatcagtcaggcctgg	7	9	12	13	0	2	1	2	0	0	1	3	1	3	1	3	3	3	4	3	3	1	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:58009731C>T	uc001spb.2	+	13	1811	c.1351C>T	c.(1351-1353)CCT>TCT	p.P451S	GEFT_uc009zpy.2_Missense_Mutation_p.P490S|GEFT_uc001spa.2_Missense_Mutation_p.P345S|uc001spc.2_Intron|GEFT_uc001spd.2_Missense_Mutation_p.P156S	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	451	PH.				regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					GGCTGCAGACCCTGCTATCAG	0.592													25	105					0	0	0	0	T	58009731	T	T	58009731	3	4	164	1	0	0	0	0	1	0	0	0	6365	623	22	4	1623	4	GEFT	12	58009731	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	100740	58009731	75842164	226	30124											
NAV3	89795	broad.mit.edu	37	chr12	78562638	78562638	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaatggtccagaccatcCtcccaaaggtatatttagaa	14	10	7	10	0	0	3	0	1	0	2	3	3	3	3	4	2	0	1	4	2	6	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:78562638C>A	uc001syp.2	+	24	5146	c.4973C>A	c.(4972-4974)CCT>CAT	p.P1658H	NAV3_uc001syo.2_Missense_Mutation_p.P1658H|NAV3_uc010sub.1_Missense_Mutation_p.P1144H|NAV3_uc009zsf.2_Missense_Mutation_p.P489H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1658						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CCAGACCATCCTCCCAAAGGT	0.378										HNSCC(70;0.22)			19	75					1.15919e-05	2.65849e-05	1	0	A	78562638	A	A	78562638	3	1	164	1	0	0	0	0	1	0	0	0	10238	681	24	4	5067	4	NAV3	12	78562638	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	20552907	78562638	55289257	227	30125											
UTP20	27340	broad.mit.edu	37	chr12	101679354	101679354	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttaatcttgacaggaggttGaaacctacttttttgagggt	10	16	10	5	0	1	3	0	3	1	0	1	4	1	4	1	3	2	1	1	3	3	8			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:101679354G>A	uc001tia.1	+	3	289	c.133G>A	c.(133-135)GAA>AAA	p.E45K	UTP20_uc009ztz.1_Missense_Mutation_p.E45K	NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	45					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						ACAGGAGGTTGAAACCTACTT	0.308													20	50					0	0	0	0	A	101679354	A	A	101679354	3	1	164	1	0	0	0	0	1	0	0	0	17167	1291	45	2	143	2	UTP20	12	101679354	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	23116716	101679354	32172541	228	30126											
MYBPC1	4604	broad.mit.edu	37	chr12	102040650	102040650	+	Frame_Shift_Del	DEL	G	-	-																															gtgatgagaaatgttccactGagctcttcgtaagaggtaaa																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:102040650delG	uc001tii.2	+	11	1102	c.1000delG	c.(1000-1002)GAGfs	p.E334fs	MYBPC1_uc001tif.1_Frame_Shift_Del_p.E347fs|MYBPC1_uc001tig.2_Frame_Shift_Del_p.E359fs|MYBPC1_uc010svq.1_Frame_Shift_Del_p.E321fs|MYBPC1_uc001tih.2_Frame_Shift_Del_p.E359fs|MYBPC1_uc001tij.2_Frame_Shift_Del_p.E334fs|MYBPC1_uc010svr.1_Frame_Shift_Del_p.E334fs|MYBPC1_uc010svs.1_Frame_Shift_Del_p.E334fs|MYBPC1_uc010svt.1_Frame_Shift_Del_p.E322fs|MYBPC1_uc010svu.1_Frame_Shift_Del_p.E315fs|MYBPC1_uc001tik.2_Frame_Shift_Del_p.E308fs	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	334	Ig-like C2-type 2.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						ATGTTCCACTGAGCTCTTCGT	0.413													---	---	---								-	102040650	-	-	102040650	7	5	164	1	0	1	0	1	0	0	0	0	10064	1291	45	0	1125	0	MYBPC1	12	102040650	Frame_Shift_Del	DEL	G	TCGA-CR-7399-01A-11D-2012-08	361296	102040650	31811245	229	30127											
RILPL1	353116	broad.mit.edu	37	chr12	124008061	124008065	+	Frame_Shift_Del	DEL	CTCCT	-	-																															ccttcatgcttctggaactcCtcctctgagaaattgacatc																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:124008061_124008065delCTCCT	uc001ufe.2	-	2	673_677	c.437_441delAGGAG	c.(436-441)GAGGAGfs	p.E146fs	RILPL1_uc010tas.1_Frame_Shift_Del_p.E146fs	NM_178314	NP_847884	Q5EBL4	RIPL1_HUMAN	Rab interacting lysosomal protein-like 1	146_147	Potential.				neuroprotection	cytosol					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		TCTGGAACTCCTCCTCTGAGAAATT	0.585													---	---	---								-	124008065	-	-	124008061	7	5	164	1	0	1	0	1	0	0	0	0	13426	680	24	0	794	0	RILPL1	12	124008061	Frame_Shift_Del	DEL	CTCCT	TCGA-CR-7399-01A-11D-2012-08	21967411	124008061	9843834	230	30128											
NCOR2	9612	broad.mit.edu	37	chr12	124862827	124862827	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcatttccgctcacgcccGacgcctccatctcctcatcc	5	10	4	22	4	4	0	3	0	1	0	8	1	7	0	7	0	0	1	7	0	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:124862827G>A	uc010tba.1	-	18	2240	c.2123C>T	c.(2122-2124)TCG>TTG	p.S708L	NCOR2_uc010tay.1_Missense_Mutation_p.S708L|NCOR2_uc010taz.1_Missense_Mutation_p.S708L|NCOR2_uc010tbb.1_Missense_Mutation_p.S708L|NCOR2_uc010tbc.1_Missense_Mutation_p.S707L|NCOR2_uc001ugj.1_Missense_Mutation_p.S708L	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	708					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCTCACGCCCGACGCCTCCAT	0.667													24	50					0	0	0	0	A	124862827	A	A	124862827	3	1	164	1	0	0	0	0	1	0	0	0	10290	1059	37	1	5565	1	NCOR2	12	124862827	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	854766	124862827	8989068	231	30129											
RIMBP2	23504	broad.mit.edu	37	chr12	130926854	130926854	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtccaccaggacgttgtagCtgctcaccgttccccatcct	6	11	8	16	2	1	0	1	0	0	0	4	1	4	1	6	1	2	5	6	1	1	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr12:130926854C>A	uc001uil.2	-	8	1156	c.992G>T	c.(991-993)AGC>ATC	p.S331I	RIMBP2_uc001uim.2_Missense_Mutation_p.S239I|RIMBP2_uc001uin.1_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	331	Fibronectin type-III 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GACGTTGTAGCTGCTCACCGT	0.562													19	99					1.96292e-10	5.25734e-10	1	0	A	130926854	A	A	130926854	3	1	164	1	0	0	0	0	1	0	0	0	13428	797	28	4	2214	4	RIMBP2	12	130926854	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	6064027	130926854	2925041	232	30130											
MRP63	78988	broad.mit.edu	37	chr13	21751049	21751049	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccgtccctctcttccgcAggcaccatgttcctgactgc	5	10	8	18	2	1	1	0	1	1	0	5	1	4	1	5	1	2	3	5	1	0	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr13:21751049A>C	uc001unw.2	+	2	486	c.-4_splice	c.e2-2		SKA3_uc001unt.2_5'Flank|SKA3_uc001unv.2_5'Flank|SKA3_uc001unu.2_5'Flank	NM_024026	NP_076931	Q9BQC6	RT63_HUMAN	mitochondrial ribosomal protein 63												0		all_cancers(29;2.76e-20)|all_epithelial(30;2.97e-18)|all_lung(29;4.58e-16)|Lung SC(185;0.0262)|Breast(139;0.147)		all cancers(112;9.43e-05)|Epithelial(112;0.000285)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|Lung(94;0.0932)		TCTCTTCCGCAGGCACCATGT	0.716													3	46					0	0	0	0	C	21751049	C	C	21751049	5	2	164	1	0	0	0	0	0	0	1	0	9826	202	7	5		5	MRP63	13	21751049	Splice_Site	SNP	A	TCGA-CR-7399-01A-11D-2012-08		21751049	93418829	233	30131											
PARP4	143	broad.mit.edu	37	chr13	25033197	25033197	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaccttttgtttcagttcAtgtgtatcactgaaaatgaa	12	16	6	7	0	3	2	3	2	0	0	3	2	3	2	1	0	1	3	1	0	5	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr13:25033197A>T	uc001upl.2	-	20	2515	c.2409T>A	c.(2407-2409)CAT>CAA	p.H803Q	PARP4_uc010tdc.1_Missense_Mutation_p.H803Q	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	803					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		GTTTCAGTTCATGTGTATCAC	0.269													7	25					0	0	0	0	T	25033197	T	T	25033197	3	4	164	1	0	0	0	0	1	0	0	0	11517	214	8	5	2825	5	PARP4	13	25033197	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	3282148	25033197	90136681	234	30132											
RXFP2	122042	broad.mit.edu	37	chr13	32313845	32313845	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttctgatcaatgtcaaaggTaaggttgctactttctcgtt	9	16	9	7	1	4	1	2	1	2	0	5	1	4	1	0	2	2	5	0	2	4	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr13:32313845T>C	uc001utt.2	+	1	165	c.94_splice	c.e1+2	p.D32_splice	RXFP2_uc010aba.2_Splice_Site_p.D15_splice	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2							integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		ATGTCAAAGGTAAGGTTGCTA	0.313													37	36					0	0	0	0	C	32313845	C	C	32313845	5	2	164	1	0	0	0	0	0	0	1	0	13825	1652	57	5	98	5	RXFP2	13	32313845	Splice_Site	SNP	T	TCGA-CR-7399-01A-11D-2012-08	7280648	32313845	82856033	235	30133											
SOHLH2	54937	broad.mit.edu	37	chr13	36748876	36748876	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tacctgggccataacggctgGagagattttctcccggatat	9	11	11	10	2	1	1	0	0	1	1	2	4	1	3	3	4	2	1	3	4	3	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr13:36748876G>C	uc001uvj.2	-	7	861	c.772C>G	c.(772-774)CCA>GCA	p.P258A	SOHLH2_uc010tei.1_Missense_Mutation_p.P335A	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	258					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		ATAACGGCTGGAGAGATTTTC	0.368													19	40					0	0	0	0	C	36748876	C	C	36748876	3	2	164	1	0	0	0	0	1	0	0	0	14988	1174	41	2	525	2	SOHLH2	13	36748876	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	4435031	36748876	78421002	236	30134											
PCDH17	27253	broad.mit.edu	37	chr13	58206853	58206853	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagcgcggcggcggagggcGcagcaagtcgggtagctacc	8	3	19	11	6	0	1	0	0	0	1	1	2	0	2	1	5	4	4	1	5	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr13:58206853G>C	uc001vhq.1	+	1	1065	c.173G>C	c.(172-174)CGC>CCC	p.R58P	PCDH17_uc010aec.1_Missense_Mutation_p.R58P	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	58	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GGCGGAGGGCGCAGCAAGTCG	0.692													4	12					0	0	0	0	C	58206853	C	C	58206853	3	2	164	1	0	0	0	0	1	0	0	0	11566	1087	38	3	175	3	PCDH17	13	58206853	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	21457977	58206853	56963025	237	30135											
KLHL1	57626	broad.mit.edu	37	chr13	70681720	70681720	+	Frame_Shift_Del	DEL	G	-	-																															gccactgccgtcctgttgcaGgcagcctccccccgccgggc																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr13:70681720delG	uc001vip.2	-	1	906	c.112delC	c.(112-114)CTGfs	p.L38fs	KLHL1_uc010thm.1_Frame_Shift_Del_p.L38fs|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	38					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TCCTGTTGCAGGCAGCCTCCC	0.607													---	---	---								-	70681720	-	-	70681720	7	5	164	1	0	1	0	1	0	0	0	0	8404	991	35	0	2178	0	KLHL1	13	70681720	Frame_Shift_Del	DEL	G	TCGA-CR-7399-01A-11D-2012-08	12474867	70681720	44488158	238	30136											
SLITRK6	84189	broad.mit.edu	37	chr13	86369426	86369426	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatctcgttaggttcataaaCgatccttcttcaagaacttc	12	14	5	10	2	4	1	2	0	2	1	7	2	5	1	1	1	2	2	1	1	6	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr13:86369426C>T	uc001vll.1	-	2	1677	c.1218G>A	c.(1216-1218)TCG>TCA	p.S406S	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	406	Extracellular (Potential).|LRR 7.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GGTTCATAAACGATCCTTCTT	0.338													9	18					0	0	0	0	T	86369426	T	T	86369426	2	4	164	1	0	0	0	0	0	0	0	1	14811	523	19	1		1	SLITRK6	13	86369426	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	15687706	86369426	28800452	239	30137											
ITGBL1	9358	broad.mit.edu	37	chr13	102359121	102359121	+	Frame_Shift_Del	DEL	C	-	-																															cacaggccacggcacatgttCctgtggtcgctgtgtttgtg																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr13:102359121delC	uc001vpb.2	+	9	1367	c.1148delC	c.(1147-1149)TCCfs	p.S383fs	ITGBL1_uc010agb.2_Frame_Shift_Del_p.S334fs|ITGBL1_uc001vpc.3_Frame_Shift_Del_p.S242fs	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	383	VIII.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGCACATGTTCCTGTGGTCGC	0.468													---	---	---								-	102359121	-	-	102359121	7	5	164	1	0	1	0	1	0	0	0	0	7941	855	30	0	1182	0	ITGBL1	13	102359121	Frame_Shift_Del	DEL	C	TCGA-CR-7399-01A-11D-2012-08	15989695	102359121	12810757	240	30138											
F10	2159	broad.mit.edu	37	chr13	113803734	113803734	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gatctacaccaaggtcaccgCcttcctcaagtggatcgaca	11	8	8	14	2	3	0	2	0	1	0	5	3	4	1	4	2	1	0	4	2	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr13:113803734C>A	uc001vsx.2	+	8	1427	c.1370C>A	c.(1369-1371)GCC>GAC	p.A457D	F10_uc001vsy.2_3'UTR|F10_uc001vsz.2_3'UTR	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	457	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAGGTCACCGCCTTCCTCAAG	0.572													19	61					5.35267e-07	1.29342e-06	1	0	A	113803734	A	A	113803734	3	1	164	1	0	0	0	0	1	0	0	0	5361	739	26	4	1400	4	F10	13	113803734	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	11444613	113803734	1366144	241	30139											
FOXG1	2290	broad.mit.edu	37	chr14	29237169	29237169	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcagggctggcagaactcCatccgccacaatctgtccct	10	7	9	15	1	1	1	0	0	1	1	4	1	4	1	4	2	2	3	4	2	3	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr14:29237169C>A	uc001wqe.2	+	1	883	c.684C>A	c.(682-684)TCC>TCA	p.S228S		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	228	Fork-head.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GGCAGAACTCCATCCGCCACA	0.597													15	9					2.32078e-09	6.00581e-09	1	0	A	29237169	A	A	29237169	2	1	164	1	0	0	0	0	0	0	0	1	6041	581	21	4		4	FOXG1	14	29237169	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08		29237169	78112371	242	30140											
CTAGE5	4253	broad.mit.edu	37	chr14	39790183	39790183	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggccttcatctgaaacaaGagcttttctctctcctccaa	9	14	5	13	0	4	2	1	1	3	1	7	2	5	2	3	1	2	1	3	1	3	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr14:39790183G>T	uc001wvg.3	+	19	1931	c.1595G>T	c.(1594-1596)AGA>ATA	p.R532I	CTAGE5_uc010tqe.1_Missense_Mutation_p.R494I|CTAGE5_uc001wuz.3_Missense_Mutation_p.R520I|CTAGE5_uc001wuy.3_Missense_Mutation_p.R452I|CTAGE5_uc001wvb.3_Intron|CTAGE5_uc001wvc.3_Intron|CTAGE5_uc001wva.3_Missense_Mutation_p.R503I|CTAGE5_uc001wvh.3_Intron|CTAGE5_uc001wvf.3_Missense_Mutation_p.R457I|CTAGE5_uc001wvi.3_Missense_Mutation_p.R537I|CTAGE5_uc010amz.2_Missense_Mutation_p.R148I|CTAGE5_uc001wvj.3_Missense_Mutation_p.R503I	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	532	Pro-rich.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		TCTGAAACAAGAGCTTTTCTC	0.418													21	76					1.40151e-16	4.02081e-16	1	0	T	39790183	T	T	39790183	3	4	164	1	0	0	0	0	1	0	0	0	4011	942	33	2	1700	2	CTAGE5	14	39790183	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	10553014	39790183	67559357	243	30141											
TIMM9	26520	broad.mit.edu	37	chr14	58875876	58875876	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttctgtaagcaatgttctGaacaggtggtctaggaatga	12	13	11	5	0	3	2	0	2	3	0	3	3	3	3	0	3	2	3	0	3	5	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr14:58875876G>A	uc010aph.2	-	4	361	c.146C>T	c.(145-147)TCA>TTA	p.S49L	TIMM9_uc001xds.2_Missense_Mutation_p.S49L|TIMM9_uc010api.2_Missense_Mutation_p.S49L	NM_012460	NP_036592	Q9Y5J7	TIM9_HUMAN	translocase of inner mitochondrial membrane 9	49	Twin CX3C motif.				protein import into mitochondrial inner membrane|sensory perception of sound|transmembrane transport	mitochondrial inner membrane presequence translocase complex|mitochondrial intermembrane space protein transporter complex	zinc ion binding				0						GCAATGTTCTGAACAGGTGGT	0.348													23	15					0	0	0	0	A	58875876	A	A	58875876	3	1	164	1	0	0	0	0	1	0	0	0	15982	1294	45	2	127	2	TIMM9	14	58875876	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	19085693	58875876	48473664	244	30142											
CKB	1152	broad.mit.edu	37	chr14	103986585	103986585	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggttggatgggcaggtgaGgatgtagcccaggtgagggt	8	8	20	5	0	0	2	0	2	0	0	0	4	0	4	1	7	1	3	1	7	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr14:103986585G>C	uc001ynf.1	-	7	921	c.841C>G	c.(841-843)CTC>GTC	p.L281V	CKB_uc001yne.1_Missense_Mutation_p.L103V|CKB_uc010awr.1_Missense_Mutation_p.L212V	NM_001823	NP_001814	P12277	KCRB_HUMAN	brain creatine kinase	281	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity				0		Melanoma(154;0.155)	Epithelial(46;0.14)		Creatine(DB00148)	GGGCAGGTGAGGATGTAGCCC	0.557													10	30					0	0	0	0	C	103986585	C	C	103986585	3	2	164	1	0	0	0	0	1	0	0	0	3461	1000	35	4	312	4	CKB	14	103986585	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	45110709	103986585	3362955	245	30143											
AHNAK2	113146	broad.mit.edu	37	chr14	105408248	105408248	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggtcggcggaaggggcctGaatgcggaggtcagtggtct	7	7	19	8	3	2	1	1	1	1	0	3	3	2	3	1	8	1	0	1	8	2	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr14:105408248G>C	uc010axc.1	-	7	13660	c.13540C>G	c.(13540-13542)CAG>GAG	p.Q4514E	AHNAK2_uc001ypx.2_Missense_Mutation_p.Q4414E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4514						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GAAGGGGCCTGAATGCGGAGG	0.627													25	63					0	0	0	0	C	105408248	C	C	105408248	3	2	164	1	0	0	0	0	1	0	0	0	415	1299	45	2	3851	2	AHNAK2	14	105408248	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1421663	105408248	1941292	246	30144											
MKRN3	7681	broad.mit.edu	37	chr15	23811612	23811612	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggctcctctacagagctCagagactgagaggaagcaga	13	5	13	10	1	2	4	1	1	1	4	3	8	3	5	1	2	3	3	1	2	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr15:23811612C>A	uc001ywh.3	+	1	1159	c.683C>A	c.(682-684)TCA>TAA	p.S228*	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Nonsense_Mutation_p.S228*	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	228						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CTACAGAGCTCAGAGACTGAG	0.582													14	33					1.52009e-12	4.23415e-12	1	0	A	23811612	A	A	23811612	4	1	164	1	0	0	0	0	0	1	0	0	9661	838	29	2	685	2	MKRN3	15	23811612	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08		23811612	78719780	247	30145											
ITGAL	3683	broad.mit.edu	37	chr16	30518144	30518144	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggacctgcacttccccccGggactctccttccgcaaggt	5	9	9	18	2	1	0	0	0	1	0	4	2	3	2	6	3	1	2	6	3	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr16:30518144G>A	uc002dyi.3	+	21	2651	c.2475G>A	c.(2473-2475)CCG>CCA	p.P825P	ITGAL_uc002dyj.3_Silent_p.P741P|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	825	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	ACTTCCCCCCGGGACTCTCCT	0.602													32	147					0	0	0	0	A	30518144	A	A	30518144	2	1	164	1	0	0	0	0	0	0	0	1	7925	1103	39	1		1	ITGAL	16	30518144	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08		30518144	59836609	248	30146											
SRCAP	10847	broad.mit.edu	37	chr16	30748614	30748614	+	Frame_Shift_Del	DEL	A	-	-																															cactcctgtcatatccgcccAtcaaactcgcagcaccacca																										TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr16:30748614delA	uc002dze.1	+	34	7638	c.7253delA	c.(7252-7254)CATfs	p.H2418fs	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Frame_Shift_Del_p.H2213fs	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2418					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			ATATCCGCCCATCAAACTCGC	0.517													---	---	---								-	30748614	-	-	30748614	7	5	164	1	0	1	0	1	0	0	0	0	15201	217	8	0	7379	0	SRCAP	16	30748614	Frame_Shift_Del	DEL	A	TCGA-CR-7399-01A-11D-2012-08	230470	30748614	59606139	249	30147											
MYLK3	91807	broad.mit.edu	37	chr16	46771727	46771727	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtcagcctcgtgccttcCtctaagggctcagggtcagg	6	9	14	12	1	4	0	3	0	1	0	6	1	5	1	3	4	2	1	3	4	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr16:46771727C>T	uc002eei.3	-	3	1013	c.897G>A	c.(895-897)GAG>GAA	p.E299E	MYLK3_uc010vge.1_Intron|MYLK3_uc002eej.1_5'UTR	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	299					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCGTGCCTTCCTCTAAGGGCT	0.667													21	116					0	0	0	0	T	46771727	T	T	46771727	2	4	164	1	0	0	0	0	0	0	0	1	10111	680	24	4		4	MYLK3	16	46771727	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	16023113	46771727	43583026	250	30148											
GPT2	84706	broad.mit.edu	37	chr16	46956246	46956246	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgtcggtgcgcctgtgccCcccagtgtctgggcaggccg	2	8	16	15	3	1	0	0	0	1	0	2	0	1	0	5	3	2	2	5	3	0	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr16:46956246C>A	uc002eel.2	+	9	1224	c.1130C>A	c.(1129-1131)CCC>CAC	p.P377H	GPT2_uc002eem.2_Missense_Mutation_p.P277H|GPT2_uc002een.2_5'Flank	NM_133443	NP_597700	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase 2 isoform 1	377					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CGCCTGTGCCCCCCAGTGTCT	0.612													18	50					2.39187e-15	6.78583e-15	1	0	A	46956246	A	A	46956246	3	1	164	1	0	0	0	0	1	0	0	0	6777	623	22	4	1160	4	GPT2	16	46956246	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	184519	46956246	43398507	251	30149											
NLRC5	84166	broad.mit.edu	37	chr16	57060492	57060492	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtatgttaccctccattcccGctgggtacagcggaccaaag	9	9	10	13	2	0	0	0	0	0	0	2	1	2	1	4	2	3	4	4	2	4	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr16:57060492G>T	uc002ekk.1	+	6	1862	c.1637G>T	c.(1636-1638)CGC>CTC	p.R546L	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.R351L|NLRC5_uc002ekl.2_Missense_Mutation_p.R351L|NLRC5_uc002ekm.2_Missense_Mutation_p.R351L|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	546					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CTCCATTCCCGCTGGGTACAG	0.612													35	64					3.6622e-26	1.10443e-25	1	0	T	57060492	T	T	57060492	3	4	164	1	0	0	0	0	1	0	0	0	10524	1087	38	3	1651	3	NLRC5	16	57060492	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	10104246	57060492	33294261	252	30150											
LRRC36	55282	broad.mit.edu	37	chr16	67404886	67404886	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcaacagtgaccctgctgTacttgtcaatgtagagcaac	11	12	8	10	0	2	2	2	1	0	1	2	2	2	2	1	0	5	4	1	0	5	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr16:67404886T>C	uc002esv.2	+	9	1254	c.1235T>C	c.(1234-1236)GTA>GCA	p.V412A	LRRC36_uc002esw.2_RNA|LRRC36_uc010ceh.2_Missense_Mutation_p.V144A|LRRC36_uc002esx.2_Missense_Mutation_p.V291A|LRRC36_uc010vjk.1_Missense_Mutation_p.V291A|LRRC36_uc010vjl.1_5'UTR|LRRC36_uc002esy.2_Intron	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	412											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		GACCCTGCTGTACTTGTCAAT	0.388													36	99					0	0	0	0	C	67404886	C	C	67404886	3	2	164	1	0	0	0	0	1	0	0	0	9040	1638	57	5	1297	5	LRRC36	16	67404886	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	10344394	67404886	22949867	253	30151											
THAP11	57215	broad.mit.edu	37	chr16	67876755	67876755	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacccgctggggccgcggccGcccgccgcaggcagcagcag	5	1	17	18	6	0	0	0	0	0	0	0	1	0	0	5	4	2	5	5	4	0	0	rs142722815	by1000genomes	TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr16:67876755G>T	uc002euo.2	+	1	543	c.298G>T	c.(298-300)GCC>TCC	p.A100S	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	100	Poly-Ala.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		ggccgcggccgcccgccgcAG	0.308													6	26					1.26484e-09	3.29548e-09	1	0	T	67876755	T	T	67876755	3	4	164	1	0	0	0	0	1	0	0	0	15909	1087	38	3	300	3	THAP11	16	67876755	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	471869	67876755	22477998	254	30152											
ATP2C2	9914	broad.mit.edu	37	chr16	84495694	84495694	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggtcatttacatcccccCgctgcagagggtcttccaga	7	9	11	14	2	2	2	1	0	1	2	4	2	4	2	4	3	2	2	4	3	1	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr16:84495694C>A	uc002fhx.2	+	26	2770	c.2681C>A	c.(2680-2682)CCG>CAG	p.P894Q	ATP2C2_uc010chj.2_Missense_Mutation_p.P923Q|ATP2C2_uc002fhy.2_Missense_Mutation_p.P911Q|ATP2C2_uc002fhz.2_Missense_Mutation_p.P743Q|ATP2C2_uc002fia.2_Missense_Mutation_p.P205Q	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	894	Helical; Name=9; (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						TACATCCCCCCGCTGCAGAGG	0.617													19	106					5.35267e-07	1.29342e-06	1	0	A	84495694	A	A	84495694	3	1	164	1	0	0	0	0	1	0	0	0	1146	652	23	3	2783	3	ATP2C2	16	84495694	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	16618939	84495694	5859059	255	30153											
TP53	7157	broad.mit.edu	37	chr17	7577106	7577106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtgcgccggtctctcccagGacaggcacaaacacgcacct	9	6	10	16	3	1	0	0	0	1	0	3	1	2	1	3	3	2	2	3	3	1	0	rs17849781		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:7577106G>A	uc002gim.2	-	8	1026	c.832C>T	c.(832-834)CCT>TCT	p.P278S	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.P278S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P146S|TP53_uc010cng.1_Missense_Mutation_p.P146S|TP53_uc002gii.1_Missense_Mutation_p.P146S|TP53_uc010cnh.1_Missense_Mutation_p.P278S|TP53_uc010cni.1_Missense_Mutation_p.P278S|TP53_uc002gij.2_Missense_Mutation_p.P278S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	278	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P278L(52)|p.P278S(48)|p.P278R(26)|p.P278T(21)|p.P278A(18)|p.P278H(11)|p.0?(7)|p.P278fs*67(5)|p.P278F(3)|p.P278fs*28(2)|p.?(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.P278P(1)|p.C277_P278insXXXXXXX(1)|p.F270_D281del12(1)|p.P278_G279insXXXXX(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTCTCCCAGGACAGGCACAA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	28					0	0	0	0	A	7577106	A	A	7577106	3	1	164	1	0	0	0	0	1	0	0	0	16448	1174	41	2	454	2	TP53	17	7577106	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08		7577106	73618104	256	30154											
TP53	7157	broad.mit.edu	37	chr17	7578211	7578211	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcaccaccacactatgtCgaaaagtgtttctgtcatcc	11	10	8	12	1	2	0	1	0	1	0	4	1	3	0	3	1	0	2	3	1	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:7578211C>A	uc002gim.2	-	6	832	c.638G>T	c.(637-639)CGA>CTA	p.R213L	TP53_uc002gig.1_Missense_Mutation_p.R213L|TP53_uc002gih.2_Missense_Mutation_p.R213L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R81L|TP53_uc010cng.1_Missense_Mutation_p.R81L|TP53_uc002gii.1_Missense_Mutation_p.R81L|TP53_uc010cnh.1_Missense_Mutation_p.R213L|TP53_uc010cni.1_Missense_Mutation_p.R213L|TP53_uc002gij.2_Missense_Mutation_p.R213L|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.R120L|TP53_uc002gio.2_Missense_Mutation_p.R81L|TP53_uc010vug.1_Missense_Mutation_p.R174L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(182)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACACTATGTCGAAAAGTGTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	18					9.31168e-06	2.14842e-05	1	0	A	7578211	A	A	7578211	3	1	164	1	0	0	0	0	1	0	0	0	16448	884	31	3	656	3	TP53	17	7578211	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1105	7578211	73616999	257	30155											
CNTROB	116840	broad.mit.edu	37	chr17	7851510	7851510	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcttgggaggaagcccctCaagtgccacgtattccaccg	9	8	10	14	2	2	0	1	0	1	0	3	2	3	2	5	2	2	1	5	2	3	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:7851510C>T	uc002gjq.2	+	17	3164	c.2245C>T	c.(2245-2247)CAA>TAA	p.Q749*	CNTROB_uc002gjp.2_Nonsense_Mutation_p.Q749*|CNTROB_uc002gjr.2_Nonsense_Mutation_p.Q651*	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	749	Pro-rich.|Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				GGAAGCCCCTCAAGTGCCACG	0.537													17	108					0	0	0	0	T	7851510	T	T	7851510	4	4	164	1	0	0	0	0	0	1	0	0	3666	827	29	2	2307	2	CNTROB	17	7851510	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	273299	7851510	73343700	258	30156											
MYH8	4626	broad.mit.edu	37	chr17	10318851	10318851	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcaattgttgcaaagtattGgatgacacgcttggtgttca	10	14	11	6	1	1	1	1	1	0	0	1	2	1	2	0	2	2	6	0	2	3	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:10318851G>A	uc002gmm.2	-	7	681	c.586C>T	c.(586-588)CAA>TAA	p.Q196*	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	196	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GCAAAGTATTGGATGACACGC	0.458									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				39	55					0	0	0	0	A	10318851	A	A	10318851	4	1	164	1	0	0	0	0	0	1	0	0	10094	1357	47	4	5363	4	MYH8	17	10318851	Nonsense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2467341	10318851	70876359	259	30157											
PIGL	9487	broad.mit.edu	37	chr17	16203244	16203244	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcagtgggacacagagcaCgtggccagagtcctccttca	10	7	12	12	1	1	2	1	0	0	2	3	3	3	3	3	2	2	2	3	2	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:16203244C>T	uc002gpv.2	+	3	410	c.378C>T	c.(376-378)CAC>CAT	p.H126H	PIGL_uc010vwd.1_Silent_p.H126H	NM_004278	NP_004269	Q9Y2B2	PIGL_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	126	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminylphosphatidylinositol deacetylase activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0934)		ACACAGAGCACGTGGCCAGAG	0.507													20	106					0	0	0	0	T	16203244	T	T	16203244	2	4	164	1	0	0	0	0	0	0	0	1	11946	535	19	1		1	PIGL	17	16203244	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	5884393	16203244	64991966	260	30158											
FLII	2314	broad.mit.edu	37	chr17	18155815	18155815	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtcaggaaatggatggcttCtgggagggtcaccaggtggt	8	9	17	7	1	3	0	2	0	1	0	3	3	3	3	1	7	0	1	1	7	1	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:18155815C>T	uc002gsr.1	-	10	1120	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K	FLII_uc002gsq.1_Missense_Mutation_p.E229K|FLII_uc010cpy.1_Missense_Mutation_p.E346K|FLII_uc010vxn.1_Missense_Mutation_p.E326K|FLII_uc010vxo.1_Missense_Mutation_p.E303K|FLII_uc002gss.1_Missense_Mutation_p.E357K	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	357	LRR 15.|Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					TGGATGGCTTCTGGGAGGGTC	0.587													10	72					0	0	0	0	T	18155815	T	T	18155815	3	4	164	1	0	0	0	0	1	0	0	0	5957	922	32	2	2824	2	FLII	17	18155815	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1952571	18155815	63039395	261	30159											
ZNF286B	729288	broad.mit.edu	37	chr17	18584121	18584121	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgctcttctcttggaaatggGgagaatcctgggaagacaga	11	10	13	7	0	2	3	0	0	2	3	4	6	3	5	1	4	1	1	1	4	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:18584121G>A	uc010vyd.1	-	3	310	c.59C>T	c.(58-60)CCC>CTC	p.P20L		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGGAAATGGGGAGAATCCTG	0.473													19	148					0	0	0	0	A	18584121	A	A	18584121	3	1	164	1	0	0	0	0	1	0	0	0	17891	1232	43	4	1521	4	ZNF286B	17	18584121	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	428306	18584121	62611089	262	30160											
KCNJ12	3768	broad.mit.edu	37	chr17	21319578	21319578	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggtggaggccacagccatGaccacccaggcccgcagctc	9	4	12	16	1	0	1	0	1	0	0	1	2	0	2	5	4	2	2	5	4	0	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:21319578G>C	uc002gyv.1	+	3	1629	c.924G>C	c.(922-924)ATG>ATC	p.M308I		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	308	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCACAGCCATGACCACCCAGG	0.607										Prostate(3;0.18)			5	101					0	0	0	0	C	21319578	C	C	21319578	3	2	164	1	0	0	0	0	1	0	0	0	8085	1290	45	2	926	2	KCNJ12	17	21319578	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2735457	21319578	59875632	263	30161											
KIAA0100	9703	broad.mit.edu	37	chr17	26942796	26942796	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaggttaaggtcaccccaGtccacactgttcttctcacc	9	10	6	16	0	3	0	2	0	2	0	5	0	4	0	5	2	0	2	5	2	1	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:26942796G>A	uc002hbu.2	-	38	6510	c.6411C>T	c.(6409-6411)GAC>GAT	p.D2137D	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_Intron|KIAA0100_uc002hbt.2_Silent_p.D466D	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2137						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GGTCACCCCAGTCCACACTGT	0.537													19	37					0	0	0	0	A	26942796	A	A	26942796	2	1	164	1	0	0	0	0	0	0	0	1	8193	1020	36	4		4	KIAA0100	17	26942796	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	5623218	26942796	54252414	264	30162											
RHBDL3	162494	broad.mit.edu	37	chr17	30615953	30615953	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcctatgagaccctgccccGggaaattgaccgcaagtggt	9	7	13	12	2	0	2	0	2	0	1	0	4	0	3	5	3	1	1	5	3	3	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:30615953G>A	uc002hhe.1	+	4	451	c.437G>A	c.(436-438)CGG>CAG	p.R146Q	RHBDL3_uc010csw.1_Missense_Mutation_p.R138Q|RHBDL3_uc010csx.1_Missense_Mutation_p.R146Q|RHBDL3_uc010csy.1_Missense_Mutation_p.R48Q|RHBDL3_uc002hhf.1_Missense_Mutation_p.R48Q	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	146					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				ACCCTGCCCCGGGAAATTGAC	0.617													13	68					0	0	0	0	A	30615953	A	A	30615953	3	1	164	1	0	0	0	0	1	0	0	0	13388	1116	39	1	451	1	RHBDL3	17	30615953	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3673157	30615953	50579257	265	30163											
CDC6	990	broad.mit.edu	37	chr17	38447873	38447873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttacctttctggtgctcctGgaactggaaaaactgcctgc	8	13	9	11	0	1	0	0	0	1	0	2	2	2	2	3	3	6	1	3	3	4	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:38447873G>A	uc002huj.1	+	4	823	c.613G>A	c.(613-615)GGA>AGA	p.G205R		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	205	ATP (Potential).				cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						TGGTGCTCCTGGAACTGGAAA	0.458													23	122					0	0	0	0	A	38447873	A	A	38447873	3	1	164	1	0	0	0	0	1	0	0	0	3098	1349	47	4	623	4	CDC6	17	38447873	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	7831920	38447873	42747337	266	30164											
HOXB6	3216	broad.mit.edu	37	chr17	46673848	46673848	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtttgctctcctttttcCacttcatgcgtcggttctgg	3	17	9	12	2	3	0	1	0	2	0	6	0	4	0	2	2	2	4	2	2	0	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:46673848C>T	uc002ins.1	-	4	927	c.602G>A	c.(601-603)TGG>TAG	p.W201*	HOXB5_uc002inr.2_5'Flank|HOXB6_uc010dbh.1_Nonsense_Mutation_p.W201*|HOXB6_uc002int.1_3'UTR	NM_018952	NP_061825	P17509	HXB6_HUMAN	homeobox B6	201	Homeobox.				anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTCCTTTTTCCACTTCATGCG	0.597													45	236					0	0	0	0	T	46673848	T	T	46673848	4	4	164	1	0	0	0	0	0	1	0	0	7344	595	21	4	76	4	HOXB6	17	46673848	Nonsense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	8225975	46673848	34521362	267	30165											
MPO	4353	broad.mit.edu	37	chr17	56348175	56348175	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcaatgagatctgggccaGggcctgtcgctgctgcatgc	6	8	16	11	1	1	1	0	1	1	1	2	2	1	1	2	3	3	4	2	3	1	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:56348175G>C	uc002ivu.1	-	12	2257	c.2080C>G	c.(2080-2082)CTG>GTG	p.L694V		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	694					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	ATCTGGGCCAGGGCCTGTCGC	0.557													4	80					0	0	0	0	C	56348175	C	C	56348175	3	2	164	1	0	0	0	0	1	0	0	0	9785	991	35	4	161	4	MPO	17	56348175	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	9674327	56348175	24847035	268	30166											
TEX14	56155	broad.mit.edu	37	chr17	56676479	56676479	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcagcctatcatcattctCgtgcattattgtctgcataa	9	15	5	12	1	5	0	3	0	2	0	6	0	5	0	2	0	3	2	2	0	3	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:56676479C>T	uc010dcz.1	-	14	2363	c.2245G>A	c.(2245-2247)GAG>AAG	p.E749K	TEX14_uc002iwr.1_Missense_Mutation_p.E743K|TEX14_uc002iws.1_Missense_Mutation_p.E743K|TEX14_uc010dda.1_Missense_Mutation_p.E523K	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	749	Potential.					cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCATCATTCTCGTGCATTATT	0.428													47	152					0	0	0	0	T	56676479	T	T	56676479	3	4	164	1	0	0	0	0	1	0	0	0	15844	893	31	1	2328	1	TEX14	17	56676479	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	328304	56676479	24518731	269	30167											
TBX2	6909	broad.mit.edu	37	chr17	59479058	59479058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcccaggcggatgttccccCccttcaaggtgcgagtcagc	6	8	11	16	2	2	0	2	0	0	0	4	2	4	1	4	3	2	1	4	3	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:59479058C>T	uc010wox.1	+	2	690	c.409C>T	c.(409-411)CCC>TCC	p.P137S	TBX2_uc002ize.2_Missense_Mutation_p.P127S|TBX2_uc002izg.2_Intron	NM_005994	NP_005985	Q13207	TBX2_HUMAN	T-box 2	137	T-box.				cell aging|positive regulation of cell proliferation		sequence-specific DNA binding				0						GATGTTCCCCCCCTTCAAGGT	0.562													5	42					0	0	0	0	T	59479058	T	T	59479058	3	4	164	1	0	0	0	0	1	0	0	0	15721	623	22	4	415	4	TBX2	17	59479058	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2802579	59479058	21716152	270	30168											
FADS6	283985	broad.mit.edu	37	chr17	72877306	72877306	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctgacacgttcaggagcagCcagtagtgagaataaaggcc	13	6	12	10	1	1	2	1	2	0	1	1	4	1	3	3	2	2	3	3	2	4	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:72877306C>A	uc002jmd.1	-	4	630	c.618G>T	c.(616-618)TGG>TGT	p.W206C	FADS6_uc010wrn.1_Intron	NM_178128	NP_835229	Q8N9I5	FADS6_HUMAN	fatty acid desaturase domain family, member 6	212	Helical; (Potential).				fatty acid biosynthetic process	integral to membrane	oxidoreductase activity				0	all_lung(278;0.172)|Lung NSC(278;0.207)					TCAGGAGCAGCCAGTAGTGAG	0.607													14	14					4.36969e-10	1.16222e-09	1	0	A	72877306	A	A	72877306	3	1	164	1	0	0	0	0	1	0	0	0	5396	740	26	4	446	4	FADS6	17	72877306	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	13398248	72877306	8317904	271	30169											
LGALS3BP	3959	broad.mit.edu	37	chr17	76967754	76967754	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggggaaggaggaggtgctCttcgagctgttggtgtccag	7	9	18	7	1	1	0	0	0	1	0	3	4	2	3	1	6	2	3	1	6	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:76967754C>T	uc002jwh.2	-	6	1841	c.1662G>A	c.(1660-1662)AAG>AAA	p.K554K	LGALS3BP_uc002jwi.2_Silent_p.K360K|LGALS3BP_uc010dhr.2_Silent_p.K360K	NM_005567	NP_005558	Q08380	LG3BP_HUMAN	galectin 3 binding protein	554					cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			central_nervous_system(3)|ovary(1)	4			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			AGGAGGTGCTCTTCGAGCTGT	0.622											OREG0024787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	136					0	0	0	0	T	76967754	T	T	76967754	2	4	164	1	0	0	0	0	0	0	0	1	8784	912	32	2		2	LGALS3BP	17	76967754	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	4090448	76967754	4227456	272	30170											
METRNL	284207	broad.mit.edu	37	chr17	81050915	81050915	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctttcttctccagcgcCgtgccgtccctgcagtgaca	4	11	9	17	3	2	1	0	1	2	0	4	1	3	1	5	0	4	1	5	0	0	2	rs146370282		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr17:81050915C>T	uc002kgh.2	+	3	685	c.560C>T	c.(559-561)CCG>CTG	p.P187L	METRNL_uc002kgi.2_Missense_Mutation_p.P105L	NM_001004431	NP_001004431	Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation	187						extracellular region					0	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			TCTCCAGCGCCGTGCCGTCCC	0.617													5	17					0	0	0	0	T	81050915	T	T	81050915	3	4	164	1	0	0	0	0	1	0	0	0	9542	652	23	1	570	1	METRNL	17	81050915	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	4083161	81050915	144295	273	30171											
POTEC	388468	broad.mit.edu	37	chr18	14537933	14537933	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgatcagcgccatgttccAgcaacattaacacacattca	13	11	5	12	1	2	1	2	1	0	0	3	1	3	1	2	0	4	2	2	0	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr18:14537933A>T	uc010dln.2	-	3	1131	c.677T>A	c.(676-678)CTG>CAG	p.L226Q	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	226	ANK 3.									skin(3)	3						GCCATGTTCCAGCAACATTAA	0.383													10	95					0	0	0	0	T	14537933	T	T	14537933	3	4	164	1	0	0	0	0	1	0	0	0	12317	188	7	5	987	5	POTEC	18	14537933	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08		14537933	63539315	274	30172											
ALPK2	115701	broad.mit.edu	37	chr18	56247140	56247140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgggttgtttgttggccaCggcactgtcacctgggtaaa	6	12	14	9	1	1	0	1	0	0	0	1	0	1	0	2	4	0	6	2	4	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr18:56247140C>T	uc002lhj.3	-	4	1082	c.868G>A	c.(868-870)GTG>ATG	p.V290M		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	290							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TTGTTGGCCACGGCACTGTCA	0.488											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	59					0	0	0	0	T	56247140	T	T	56247140	3	4	164	1	0	0	0	0	1	0	0	0	545	536	19	1	5684	1	ALPK2	18	56247140	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	41709207	56247140	21830108	275	30173											
CBLN2	147381	broad.mit.edu	37	chr18	70209167	70209167	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctagggaggaggtgacggCgccgtccgccgacgggctgg	5	4	20	12	6	0	1	0	1	0	0	1	4	1	3	4	6	0	1	4	6	1	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr18:70209167C>A	uc002lku.2	-	2	464	c.229G>T	c.(229-231)GCC>TCC	p.A77S	CBLN2_uc002lkv.2_Missense_Mutation_p.A77S	NM_182511	NP_872317	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	77						integral to membrane					0		Esophageal squamous(42;0.131)				GAGGTGACGGCGCCGTCCGCC	0.711													8	15					0.000157383	0.000344445	1	0	A	70209167	A	A	70209167	3	1	164	1	0	0	0	0	1	0	0	0	2717	768	27	3	457	3	CBLN2	18	70209167	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	13962027	70209167	7868081	276	30174											
ARRDC5	645432	broad.mit.edu	37	chr19	4902866	4902866	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggggtagagagacattccTctctgtcccccatgtccctg	6	10	12	13	0	1	2	0	0	1	2	5	3	4	2	4	3	0	1	4	3	1	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:4902866T>C	uc002mbm.2	-	1	14	c.14A>G	c.(13-15)GAG>GGG	p.E5G		NM_001080523	NP_001073992	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	5					signal transduction						0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		GAGACATTCCTCTCTGTCCCC	0.542													21	33					0	0	0	0	C	4902866	C	C	4902866	3	2	164	1	0	0	0	0	1	0	0	0	988	1551	54	5	1026	5	ARRDC5	19	4902866	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08		4902866	54226117	277	30175											
PRR22	163154	broad.mit.edu	37	chr19	5783814	5783814	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggcccggggccctcaggCgggaagtagggcaagagaaa	10	4	17	10	2	2	1	1	0	1	1	2	3	2	2	2	6	0	2	2	6	4	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:5783814C>A	uc002mdb.1	-	1	797	c.438G>T	c.(436-438)CCG>CCT	p.P146P	PRR22_uc010xiv.1_Silent_p.P148P	NM_153359	NP_699190	Q8IZ63	PRR22_HUMAN	proline rich 22 isoform 2	146	Pro-rich.										0						GGCCCTCAGGCGGGAAGTAGG	0.716													6	4					0.00116845	0.00243214	1	0	A	5783814	A	A	5783814	2	1	164	1	0	0	0	0	0	0	0	1	12655	755	27	3		3	PRR22	19	5783814	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	880948	5783814	53345169	278	30176											
MUC16	94025	broad.mit.edu	37	chr19	9012852	9012852	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctcgtactgcaggttGgtgatggtgaagttgagggt	6	13	15	7	1	0	3	0	3	0	0	3	3	2	3	2	4	2	4	2	4	2	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:9012852G>T	uc002mkp.2	-	34	38796	c.38592C>A	c.(38590-38592)ACC>ACA	p.T12864T	MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12866	SEA 6.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACTGCAGGTTGGTGATGGTGA	0.547													7	139					0.000274275	0.000590154	1	0	T	9012852	T	T	9012852	2	4	164	1	0	0	0	0	0	0	0	1	10026	1335	47	4		4	MUC16	19	9012852	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3229038	9012852	50116131	279	30177											
MUC16	94025	broad.mit.edu	37	chr19	9049185	9049185	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgttgtagctggttcacCaggggagtttgtcagagctc	8	12	13	8	0	2	1	2	0	0	1	3	2	2	2	1	3	3	6	1	3	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:9049185C>T	uc002mkp.2	-	5	32650	c.32446G>A	c.(32446-32448)GGT>AGT	p.G10816S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10818	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTGGTTCACCAGGGGAGTTT	0.478													30	82					0	0	0	0	T	9049185	T	T	9049185	3	4	164	1	0	0	0	0	1	0	0	0	10026	594	21	4	11397	4	MUC16	19	9049185	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	36333	9049185	50079798	280	30178											
MUC16	94025	broad.mit.edu	37	chr19	9085769	9085769	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaagagactgaattctcatGggtaggggaagcagacactg	14	7	14	6	0	1	4	1	1	1	3	2	6	1	5	0	3	1	2	0	3	4	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:9085769G>A	uc002mkp.2	-	1	6250	c.6046C>T	c.(6046-6048)CAT>TAT	p.H2016Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2016	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAATTCTCATGGGTAGGGGAA	0.463													17	52					0	0	0	0	A	9085769	A	A	9085769	3	1	164	1	0	0	0	0	1	0	0	0	10026	1348	47	4	37813	4	MUC16	19	9085769	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	36584	9085769	50043214	281	30179											
OR7D2	162998	broad.mit.edu	37	chr19	9297244	9297244	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggggtccacttcacttctGcggtgactcactcttcccag	5	13	9	14	1	4	1	2	1	2	0	6	1	6	1	2	3	1	0	2	3	0	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:9297244G>A	uc002mkz.1	+	1	975	c.787G>A	c.(787-789)GCG>ACG	p.A263T		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	263	Extracellular (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						CTTCACTTCTGCGGTGACTCA	0.512													23	58					0	0	0	0	A	9297244	A	A	9297244	3	1	164	1	0	0	0	0	1	0	0	0	11273	1319	46	4	789	4	OR7D2	19	9297244	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	211475	9297244	49831739	282	30180											
ZNF699	374879	broad.mit.edu	37	chr19	9415941	9415942	+	5'Flank	DEL	AT	-	-																															aacaactcccctcaaaacacAtacacacacacacacacaca																								rs8100157		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:9415941_9415942delAT	uc002mlc.1	-							NM_198535	NP_940937	Q32M78	ZN699_HUMAN	zinc finger protein 699						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTCAAAacacatacacacacac	0.376													---	---	---								-	9415942	-	-	9415941	6	5	164	0	1	1	0	1	0	0	0	0	18168	232	8	0		0	ZNF699	19	9415941	5'Flank	DEL	AT	TCGA-CR-7399-01A-11D-2012-08	118697	9415941	49713042	283	30181											
CPAMD8	27151	broad.mit.edu	37	chr19	17122307	17122307	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcctcagatttggagagacGgtgaagatgcttatgagcac	11	9	14	7	1	1	5	1	2	0	3	1	7	1	6	1	3	2	2	1	3	2	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:17122307G>A	uc002nfb.2	-	5	626	c.594C>T	c.(592-594)ACC>ACT	p.T198T		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	151						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TTGGAGAGACGGTGAAGATGC	0.587													30	70					0	0	0	0	A	17122307	A	A	17122307	2	1	164	1	0	0	0	0	0	0	0	1	3810	1103	39	1		1	CPAMD8	19	17122307	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	7706366	17122307	42006676	284	30182											
ZNF737	100129842	broad.mit.edu	37	chr19	20727499	20727499	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgtagggtttctctccagTatgaattctcttatgtctag	7	19	8	7	0	3	1	0	1	3	0	6	1	4	1	1	1	0	3	1	1	5	7			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:20727499T>G	uc002npa.2	-	4	1690	c.1510A>C	c.(1510-1512)ACT>CCT	p.T504P		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	504					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TTCTCTCCAGTATGAATTCTC	0.393													4	16					0	0	0	0	G	20727499	G	G	20727499	3	3	164	1	0	0	0	0	1	0	0	0	18193	1638	57	5	104	5	ZNF737	19	20727499	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	3605192	20727499	38401484	285	30183											
ZNF257	113835	broad.mit.edu	37	chr19	22272134	22272134	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaagccttttaatcgtttcTcataccttaccgtacataag	11	14	5	11	2	1	0	1	0	1	0	3	0	1	0	3	0	4	3	3	0	6	7			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:22272134T>A	uc010ecx.2	+	4	1751	c.1582T>A	c.(1582-1584)TCA>ACA	p.S528T	ZNF257_uc010ecy.2_Missense_Mutation_p.S496T	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	528	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAATCGTTTCTCATACCTTAC	0.388													6	24					0	0	0	0	A	22272134	A	A	22272134	3	1	164	1	0	0	0	0	1	0	0	0	17867	1551	54	5	1596	5	ZNF257	19	22272134	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	1544635	22272134	36856849	286	30184											
ZNF254	9534	broad.mit.edu	37	chr19	24310288	24310288	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctacaaatgtgaagaatgtGgcaaatcttttagccaatcc	14	11	7	9	0	1	2	0	1	1	1	2	2	2	2	3	1	2	1	3	1	7	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:24310288G>T	uc002nru.2	+	4	1620	c.1486G>T	c.(1486-1488)GGC>TGC	p.G496C	ZNF254_uc010xrk.1_Missense_Mutation_p.G411C	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	496	C2H2-type 11.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				TGAAGAATGTGGCAAATCTTT	0.398													10	40					0.000442599	0.000939144	1	0	T	24310288	T	T	24310288	3	4	164	1	0	0	0	0	1	0	0	0	17865	1348	47	4	1500	4	ZNF254	19	24310288	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	2038154	24310288	34818695	287	30185											
DLL3	10683	broad.mit.edu	37	chr19	39994757	39994757	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcatggcttctgtgaacaGcccggtgaatgccgatgcct	8	9	13	11	2	1	2	0	2	1	0	1	4	1	2	3	2	5	2	3	2	2	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:39994757G>T	uc002olx.2	+	5	757	c.699G>T	c.(697-699)CAG>CAT	p.Q233H	DLL3_uc010egq.2_Missense_Mutation_p.Q233H|DLL3_uc002olw.2_Missense_Mutation_p.Q233H	NM_016941	NP_058637	Q9NYJ7	DLL3_HUMAN	delta-like 3 protein isoform 1 precursor	233	EGF-like 1.|Extracellular (Potential).				Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			central_nervous_system(2)|breast(1)	3	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TCTGTGAACAGCCCGGTGAAT	0.647													9	47					3.86212e-05	8.59995e-05	1	0	T	39994757	T	T	39994757	3	4	164	1	0	0	0	0	1	0	0	0	4589	962	34	4	717	4	DLL3	19	39994757	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	15684469	39994757	19134226	288	30186											
AXL	558	broad.mit.edu	37	chr19	41754717	41754717	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaaggtggctgtgaagaCgatgaagagtgagttacgtg	11	9	15	6	2	1	5	1	3	0	2	1	6	1	5	1	2	1	2	1	2	4	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:41754717C>T	uc010ehj.2	+	14	1893	c.1703C>T	c.(1702-1704)ACG>ATG	p.T568M	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehk.2_Missense_Mutation_p.T559M	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	568	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						GCTGTGAAGACGATGAAGAGT	0.547													5	27					0	0	0	0	T	41754717	T	T	41754717	3	4	164	1	0	0	0	0	1	0	0	0	1240	536	19	1	1757	1	AXL	19	41754717	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1759960	41754717	17374266	289	30187											
PSG2	5670	broad.mit.edu	37	chr19	43579547	43579547	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtcactgcggctggcactcCctgagttccgtatttcacat	6	12	10	13	2	2	1	2	1	0	0	4	1	4	1	2	3	1	4	2	3	1	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:43579547C>A	uc002ovr.2	-	3	761	c.668G>T	c.(667-669)GGG>GTG	p.G223V	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Missense_Mutation_p.G223V|PSG2_uc010eiq.1_Missense_Mutation_p.G223V|PSG2_uc002ovs.3_Missense_Mutation_p.G223V|PSG2_uc002ovt.3_Missense_Mutation_p.G223V	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	223	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				GCTGGCACTCCCTGAGTTCCG	0.507													69	306					9.96456e-45	3.07776e-44	1	0	A	43579547	A	A	43579547	3	1	164	1	0	0	0	0	1	0	0	0	12717	623	22	4	351	4	PSG2	19	43579547	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	1824830	43579547	15549436	290	30188											
FKRP	79147	broad.mit.edu	37	chr19	47259844	47259844	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcaactgcgagcagctgcgGggggcagaggccggctcggt	6	4	20	11	4	0	1	0	0	0	1	1	2	0	1	1	7	5	5	1	7	1	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:47259844G>C	uc002pfn.2	+	4	1434	c.1137G>C	c.(1135-1137)CGG>CGC	p.R379R	FKRP_uc002pfp.2_Silent_p.R379R	NM_024301	NP_077277	Q9H9S5	FKRP_HUMAN	fukutin-related protein	379						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			pancreas(1)	1		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		AGCAGCTGCGGGGGGCAGAGG	0.657													4	17					0	0	0	0	C	47259844	C	C	47259844	2	2	164	1	0	0	0	0	0	0	0	1	5949	1219	43	4		4	FKRP	19	47259844	Silent	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3680297	47259844	11869139	291	30189											
SIGLEC11	114132	broad.mit.edu	37	chr19	50462047	50462047	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcccacggtctgtccccAccgggtccagctcagcctgg	4	6	14	17	2	2	0	1	0	1	0	4	0	4	0	6	5	2	1	6	5	0	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:50462047A>C	uc010ybh.1	-	7	1307	c.1216T>G	c.(1216-1218)TGG>GGG	p.W406G	SIGLEC11_uc010ybi.1_Missense_Mutation_p.W406G	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	406	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		GTCTGTCCCCACCGGGTCCAG	0.682													3	70					0	0	0	0	C	50462047	C	C	50462047	3	2	164	1	0	0	0	0	1	0	0	0	14372	159	6	5	900	5	SIGLEC11	19	50462047	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08	3202203	50462047	8666936	292	30190											
SIGLEC6	946	broad.mit.edu	37	chr19	52034090	52034090	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagggaggtgggggcagctGacatccaggagaagatgggg	10	4	20	7	0	0	3	0	1	0	2	1	5	1	4	2	7	1	2	2	7	1	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:52034090G>A	uc002pwy.2	-	3	713	c.551C>T	c.(550-552)TCA>TTA	p.S184L	SIGLEC6_uc002pwz.2_Missense_Mutation_p.S184L|SIGLEC6_uc002pxa.2_Missense_Mutation_p.S184L|SIGLEC6_uc010ydb.1_Missense_Mutation_p.S137L|SIGLEC6_uc010ydc.1_Missense_Mutation_p.S173L|SIGLEC6_uc010eoz.1_Missense_Mutation_p.S162L|SIGLEC6_uc010epb.1_Missense_Mutation_p.S137L|SIGLEC6_uc010epa.1_Missense_Mutation_p.S173L	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	184	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GGGGGCAGCTGACATCCAGGA	0.657													15	66					0	0	0	0	A	52034090	A	A	52034090	3	1	164	1	0	0	0	0	1	0	0	0	14377	1294	45	2	867	2	SIGLEC6	19	52034090	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1572043	52034090	7094893	293	30191											
ZNF615	284370	broad.mit.edu	37	chr19	52505068	52505068	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctcctctcactcaccaGaacagattcgagagtagatt	11	10	8	12	1	2	4	2	0	1	4	5	5	3	4	2	0	2	3	2	0	2	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:52505068G>T	uc002pye.1	-	5	528	c.236C>A	c.(235-237)TCT>TAT	p.S79Y	ZNF615_uc002pyf.1_Missense_Mutation_p.S79Y|ZNF615_uc002pyg.1_Translation_Start_Site|ZNF615_uc002pyh.1_Missense_Mutation_p.S79Y|ZNF615_uc010epi.1_Missense_Mutation_p.S75Y|ZNF615_uc010ydg.1_Missense_Mutation_p.S84Y	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	79	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TCACTCACCAGAACAGATTCG	0.507													8	33					5.18039e-06	1.20248e-05	1	0	T	52505068	T	T	52505068	3	4	164	1	0	0	0	0	1	0	0	0	18107	942	33	2	1967	2	ZNF615	19	52505068	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	470978	52505068	6623915	294	30192											
ZNF320	162967	broad.mit.edu	37	chr19	53367282	53367282	+	RNA	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctggaggaacattttccTcacccacagactccaggttc	9	11	8	13	0	2	1	1	0	1	1	5	3	4	3	3	3	1	1	3	3	1	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:53367282T>A	uc010eqh.1	-	3		c.395A>T			ZNF320_uc010eqi.1_RNA			A2RRD8	ZN320_HUMAN	Homo sapiens full length insert cDNA clone ZD42C02.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		AACATTTTCCTCACCCACAGA	0.468													18	41					0	0	0	0	A	53367282	A	A	53367282	1	1	164	0	1	0	0	0	0	0	0	0	17906	1566	54	5		5	ZNF320	19	53367282	RNA	SNP	T	TCGA-CR-7399-01A-11D-2012-08	862214	53367282	5761701	295	30193											
NLRP13	126204	broad.mit.edu	37	chr19	56422098	56422098	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggaatcaaacttgcttgTccttcatgagggagagacag	11	10	11	9	0	2	2	2	1	0	1	3	5	3	4	2	2	2	1	2	2	2	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:56422098T>A	uc010ygg.1	-	6	2138	c.2113A>T	c.(2113-2115)ACA>TCA	p.T705S		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	705							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		AACTTGCTTGTCCTTCATGAG	0.438													18	75					0	0	0	0	A	56422098	A	A	56422098	3	1	164	1	0	0	0	0	1	0	0	0	10529	1681	58	5	1040	5	NLRP13	19	56422098	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	3054816	56422098	2706885	296	30194											
PEG3	5178	broad.mit.edu	37	chr19	57326339	57326339	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcatacagctgctctccagtGtaatctctctgatactcgct	8	14	6	13	1	4	1	1	1	3	0	7	1	4	1	1	0	4	4	1	0	3	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr19:57326339G>T	uc002qnu.2	-	7	3822	c.3471C>A	c.(3469-3471)TAC>TAA	p.Y1157*	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Nonsense_Mutation_p.Y1128*|PEG3_uc002qnv.2_Nonsense_Mutation_p.Y1157*|PEG3_uc002qnw.2_Nonsense_Mutation_p.Y1033*|PEG3_uc002qnx.2_Nonsense_Mutation_p.Y1031*|PEG3_uc010etr.2_Nonsense_Mutation_p.Y1157*	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1157					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GCTCTCCAGTGTAATCTCTCT	0.448													27	111					1.74197e-06	4.16985e-06	1	0	T	57326339	T	T	57326339	4	4	164	1	0	0	0	0	0	1	0	0	11774	1372	48	4	1299	4	PEG3	19	57326339	Nonsense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	904241	57326339	1802644	297	30195											
PLCB1	23236	broad.mit.edu	37	chr20	8637904	8637904	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caacaacctttgccctcgacCtgaaattgataacatctttt	12	13	4	12	1	1	2	0	2	1	0	2	3	1	2	3	0	4	0	3	0	4	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr20:8637904C>A	uc002wnb.2	+	8	671	c.668C>A	c.(667-669)CCT>CAT	p.P223H	PLCB1_uc010zrb.1_Missense_Mutation_p.P122H|PLCB1_uc002wna.2_Missense_Mutation_p.P223H|PLCB1_uc002wnc.1_Missense_Mutation_p.P122H	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	223					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TGCCCTCGACCTGAAATTGAT	0.393													10	71					4.68919e-08	1.16621e-07	1	0	A	8637904	A	A	8637904	3	1	164	1	0	0	0	0	1	0	0	0	12082	681	24	4	698	4	PLCB1	20	8637904	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08		8637904	54387616	298	30196											
KRTAP15-1	254950	broad.mit.edu	37	chr21	31812833	31812833	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcccaccagctgccagaCatcctgcactttggccagat	9	8	9	15	0	0	3	0	1	0	2	1	3	1	3	5	1	4	2	5	1	0	1			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr21:31812833C>A	uc002yod.2	+	1	188	c.188C>A	c.(187-189)ACA>AAA	p.T63K		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	63						intermediate filament					0						AGCTGCCAGACATCCTGCACT	0.512													15	59					7.93312e-07	1.91093e-06	1	0	A	31812833	A	A	31812833	3	1	164	1	0	0	0	0	1	0	0	0	8565	478	17	4	190	4	KRTAP15-1	21	31812833	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08		31812833	16317062	299	30197											
OR11H1	81061	broad.mit.edu	37	chr22	16449678	16449678	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttgtagtaaagagtgagaAgaggaagatctgaattgtcc	14	11	13	3	0	1	5	0	2	1	4	2	7	2	6	1	1	0	3	1	1	6	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr22:16449678A>T	uc011agd.1	-	1	127	c.127T>A	c.(127-129)TTC>ATC	p.F43I		NM_001005239	NP_001005239	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H,	43	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		AAGAGTGAGAAGAGGAAGATC	0.423													8	146					0	0	0	0	T	16449678	T	T	16449678	3	4	164	1	0	0	0	0	1	0	0	0	10980	72	3	5	855	5	OR11H1	22	16449678	Missense_Mutation	SNP	A	TCGA-CR-7399-01A-11D-2012-08		16449678	34854888	300	30198											
PPM1F	9647	broad.mit.edu	37	chr22	22285593	22285593	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaaaatgacctgggaatccCcgagccaggcgacgtgcagg	11	4	13	13	3	0	1	0	1	0	0	1	4	1	2	5	3	2	1	5	3	3	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chr22:22285593C>A	uc002zvp.1	-	6	932	c.818G>T	c.(817-819)GGG>GTG	p.G273V	PPM1F_uc011aik.1_Missense_Mutation_p.G169V|PPM1F_uc002zvq.2_Missense_Mutation_p.G273V	NM_014634	NP_055449	P49593	PPM1F_HUMAN	protein phosphatase 1F	273					apoptosis|protein dephosphorylation	protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(2)|large_intestine(1)|breast(1)|kidney(1)	5	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.155)		CTGGGAATCCCCGAGCCAGGC	0.542													21	52					1.9806e-07	4.86262e-07	1	0	A	22285593	A	A	22285593	3	1	164	1	0	0	0	0	1	0	0	0	12399	623	22	4	558	4	PPM1F	22	22285593	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	5835915	22285593	29018973	301	30199											
FANCB	2187	broad.mit.edu	37	chrX	14882732	14882732	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attattggatataaaggataCaacgaaaaagaggtttcctc	17	11	8	5	1	0	1	0	0	0	1	2	4	1	3	1	3	2	1	1	3	8	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:14882732C>G	uc004cwg.1	-	3	1169	c.901G>C	c.(901-903)GTA>CTA	p.V301L	FANCB_uc004cwh.1_Missense_Mutation_p.V301L	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	301					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					ATAAAGGATACAACGAAAAAG	0.378								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				9	39					0	0	0	0	G	14882732	G	G	14882732	3	3	164	1	0	0	0	0	1	0	0	0	5695	478	17	4	1710	4	FANCB	23	14882732	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08		14882732	140387828	302	30200											
CDKL5	6792	broad.mit.edu	37	chrX	18638053	18638053	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagaagcaaggatttttcagGtcaatgaaaaagaaaaagaa	21	7	10	3	0	2	4	2	1	0	3	2	6	2	5	0	2	1	1	0	2	8	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:18638053G>T	uc004cym.2	+	16	2596	c.2343G>T	c.(2341-2343)AGG>AGT	p.R781S	CDKL5_uc004cyn.2_Missense_Mutation_p.R781S	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	781					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					GATTTTTCAGGTCAATGAAAA	0.289													8	14					1.26484e-09	3.29548e-09	1	0	T	18638053	T	T	18638053	3	4	164	1	0	0	0	0	1	0	0	0	3172	1252	44	4	2401	4	CDKL5	23	18638053	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3755321	18638053	136632507	303	30201											
PHKA2	5256	broad.mit.edu	37	chrX	18913306	18913306	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accatcgatggagagaccgtGgcactggaggcagaatagag	13	5	15	8	2	0	3	0	0	0	3	1	7	0	5	2	4	0	2	2	4	2	1	rs148627941		TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:18913306G>A	uc004cyv.3	-	31	3716	c.3286C>T	c.(3286-3288)CAC>TAC	p.H1096Y	PHKA2_uc004cyu.3_Missense_Mutation_p.H402Y|PHKA2_uc010nfe.1_Missense_Mutation_p.H128Y|PHKA2_uc010nff.1_RNA	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1096	Calmodulin-binding (Potential).				glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					GAGAGACCGTGGCACTGGAGG	0.552													23	65					0	0	0	0	A	18913306	A	A	18913306	3	1	164	1	0	0	0	0	1	0	0	0	11899	1348	47	4	433	4	PHKA2	23	18913306	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	275253	18913306	136357254	304	30202											
MAGEB18	286514	broad.mit.edu	37	chrX	26158123	26158123	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacgtctagcagcttctccCatgctaagtgaaatctgagg	10	10	9	12	1	3	2	0	2	3	0	4	2	3	2	2	1	3	3	2	1	3	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:26158123C>A	uc004dbq.1	+	2	1208	c.1021C>A	c.(1021-1023)CAT>AAT	p.H341N		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	341							protein binding			central_nervous_system(1)	1						CAGCTTCTCCCATGCTAAGTG	0.502													3	9					0.004672	0.00959451	1	0	A	26158123	A	A	26158123	3	1	164	1	0	0	0	0	1	0	0	0	9228	594	21	4	1023	4	MAGEB18	23	26158123	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	7244817	26158123	129112437	305	30203											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29973487	29973487	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaccaaaatgcaacaagttGaactccaagttctggaaacg	16	7	9	9	1	1	1	0	1	1	0	2	3	2	3	2	2	4	3	2	2	7	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:29973487G>C	uc004dby.2	+	11	2149	c.1641G>C	c.(1639-1641)TTG>TTC	p.L547F		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	547	Cytoplasmic (Potential).|TIR.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						GCAACAAGTTGAACTCCAAGT	0.448													7	16					0	0	0	0	C	29973487	C	C	29973487	3	2	164	1	0	0	0	0	1	0	0	0	7700	1281	45	2	1679	2	IL1RAPL1	23	29973487	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3815364	29973487	125297073	306	30204											
MAGEB1	4112	broad.mit.edu	37	chrX	30269597	30269597	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaggcgtcgcactactgcCacgacttttagagcgcgttc	7	9	11	14	5	0	1	0	0	0	1	2	2	0	1	2	1	3	2	2	1	2	4			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:30269597C>A	uc004dcc.2	+	4	1307	c.987C>A	c.(985-987)GCC>GCA	p.A329A	MAGEB1_uc004dcd.2_Silent_p.A329A|MAGEB1_uc004dce.2_Silent_p.A329A	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	329											0						GCACTACTGCCACGACTTTTA	0.532													13	54					2.27111e-07	5.55805e-07	1	0	A	30269597	A	A	30269597	2	1	164	1	0	0	0	0	0	0	0	1	9225	581	21	4		4	MAGEB1	23	30269597	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	296110	30269597	125000963	307	30205											
DMD	1756	broad.mit.edu	37	chrX	32366523	32366523	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttatcacaaccaatttacCatatctttattgaagtcttc	12	18	2	9	0	3	1	1	1	2	0	4	1	3	1	2	0	2	0	2	0	7	9			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:32366523C>T	uc004dda.1	-	38	5692	c.5448G>A	c.(5446-5448)ATG>ATA	p.M1816I	DMD_uc004dcw.2_Missense_Mutation_p.M472I|DMD_uc004dcx.2_Missense_Mutation_p.M475I|DMD_uc004dcz.2_Missense_Mutation_p.M1693I|DMD_uc004dcy.1_Missense_Mutation_p.M1812I|DMD_uc004ddb.1_Missense_Mutation_p.M1808I|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1816	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ACCAATTTACCATATCTTTAT	0.353													12	37					0	0	0	0	T	32366523	T	T	32366523	3	4	164	1	0	0	0	0	1	0	0	0	4602	608	21	4	5925	4	DMD	23	32366523	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2096926	32366523	122904037	308	30206											
RPGR	6103	broad.mit.edu	37	chrX	38145138	38145138	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttctccttcctcctctccTtcctcttcctctccttcccc	0	18	0	23	0	5	0	0	0	5	0	13	0	10	0	9	0	0	0	9	0	0	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:38145138T>C	uc004ded.1	-	15	3282	c.3114A>G	c.(3112-3114)GAA>GAG	p.E1038E	RPGR_uc004deb.2_Intron|RPGR_uc004dea.2_Intron|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						cctcctctccttcctcttcct	0.045													3	12					0	0	0	0	C	38145138	C	C	38145138	2	2	164	1	0	0	0	0	0	0	0	1	13613	1606	56	5		5	RPGR	23	38145138	Silent	SNP	T	TCGA-CR-7399-01A-11D-2012-08	5778615	38145138	117125422	309	30207											
PFKFB1	5207	broad.mit.edu	37	chrX	54978369	54978369	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaactgagaggccagagtcaCctccgatgcggcctctgatg	9	7	13	12	2	2	3	1	2	1	2	3	6	3	3	4	2	2	0	4	2	1	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:54978369C>G	uc004dty.1	-	8	886	c.815G>C	c.(814-816)GGT>GCT	p.G272A	PFKFB1_uc010nkd.1_Intron|PFKFB1_uc011mol.1_Missense_Mutation_p.G207A	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	272	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						GCCAGAGTCACCTCCGATGCG	0.582													8	11					0	0	0	0	G	54978369	G	G	54978369	3	3	164	1	0	0	0	0	1	0	0	0	11815	507	18	4	628	4	PFKFB1	23	54978369	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	16833231	54978369	100292191	310	30208											
MTMR8	55613	broad.mit.edu	37	chrX	63563520	63563520	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaaattccagcatccataaTagctttaatgtgtcttaacc	14	13	5	9	0	1	0	0	0	1	0	3	1	3	0	3	0	3	2	3	0	6	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:63563520T>G	uc004dvs.2	-	8	1014	c.946A>C	c.(946-948)ATT>CTT	p.I316L	MTMR8_uc011mou.1_Missense_Mutation_p.I316L|MTMR8_uc004dvt.1_Missense_Mutation_p.I316L	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	316	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						GCATCCATAATAGCTTTAATG	0.323													4	15					0	0	0	0	G	63563520	G	G	63563520	3	3	164	1	0	0	0	0	1	0	0	0	10002	1406	49	5	1196	5	MTMR8	23	63563520	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	8585151	63563520	91707040	311	30209											
AWAT2	158835	broad.mit.edu	37	chrX	69262102	69262102	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttggtgaagccacgtccaTagaaagcacaagggtagatg	13	8	12	8	1	1	3	0	1	1	2	2	3	2	3	2	2	2	2	2	2	5	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:69262102T>C	uc004dxt.1	-	6	788	c.782A>G	c.(781-783)TAT>TGT	p.Y261C		NM_001002254	NP_001002254	Q6E213	AWAT2_HUMAN	wax synthase 2	261						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity				0						GCCACGTCCATAGAAAGCACA	0.537													12	26					0	0	0	0	C	69262102	C	C	69262102	3	2	164	1	0	0	0	0	1	0	0	0	1237	1406	49	5	227	5	AWAT2	23	69262102	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	5698582	69262102	86008458	312	30210											
TAF9B	51616	broad.mit.edu	37	chrX	77393354	77393354	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtggcaaaggggtttgattTttctgccttgcgatatccag	8	14	12	7	1	1	1	0	1	1	0	2	2	2	1	2	3	2	2	2	3	2	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:77393354T>C	uc004eda.2	-	4	368	c.297A>G	c.(295-297)AAA>AAG	p.K99K		NM_015975	NP_057059	Q9HBM6	TAF9B_HUMAN	transcription associated factor 9B	99					negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding				0						GGGTTTGATTTTTCTGCCTTG	0.343													20	55					0	0	0	0	C	77393354	C	C	77393354	2	2	164	1	0	0	0	0	0	0	0	1	15602	1838	64	5		5	TAF9B	23	77393354	Silent	SNP	T	TCGA-CR-7399-01A-11D-2012-08	8131252	77393354	77877206	313	30211											
BRWD3	254065	broad.mit.edu	37	chrX	79999597	79999597	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgcacaagttcgaagacaCcatactcttactaccttatc	12	11	6	12	1	1	1	0	0	1	1	3	2	1	1	2	1	4	2	2	1	6	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:79999597C>G	uc004edt.2	-	8	1010	c.747G>C	c.(745-747)TGG>TGC	p.W249C	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_Missense_Mutation_p.W78C|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_5'UTR|BRWD3_uc004edr.2_5'UTR|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_5'UTR|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_5'UTR|BRWD3_uc004eea.2_5'UTR|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	249	WD 3.									ovary(4)	4						TTCGAAGACACCATACTCTTA	0.413													8	43					0	0	0	0	G	79999597	G	G	79999597	3	3	164	1	0	0	0	0	1	0	0	0	1531	508	18	4	4797	4	BRWD3	23	79999597	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	2606243	79999597	75270963	314	30212											
DACH2	117154	broad.mit.edu	37	chrX	85969660	85969660	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccatctcaatactattgcCaacatggctgctgcagcaca	13	9	6	13	0	1	0	1	0	1	0	2	0	1	0	2	1	7	4	2	1	5	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:85969660C>A	uc004eew.2	+	6	1211	c.1041C>A	c.(1039-1041)GCC>GCA	p.A347A	DACH2_uc004eex.2_Silent_p.A334A|DACH2_uc010nmq.2_Silent_p.A213A|DACH2_uc011mra.1_Silent_p.A180A|DACH2_uc010nmr.2_Silent_p.A128A|DACH2_uc004eey.2_Silent_p.A30A|DACH2_uc004eez.2_Silent_p.A30A	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						ATACTATTGCCAACATGGCTG	0.448													8	65					0.000442599	0.000939144	1	0	A	85969660	A	A	85969660	2	1	164	1	0	0	0	0	0	0	0	1	4238	581	21	4		4	DACH2	23	85969660	Silent	SNP	C	TCGA-CR-7399-01A-11D-2012-08	5970063	85969660	69300900	315	30213											
ARMCX2	9823	broad.mit.edu	37	chrX	100912388	100912388	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaatcctgacccaaggtcgaTtgtgaatccggctcttagcc	9	10	10	12	2	1	2	0	2	1	0	4	4	3	2	4	2	1	1	4	2	4	2			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:100912388T>C	uc004eid.2	-	3	542	c.187A>G	c.(187-189)ATC>GTC	p.I63V	ARMCX2_uc004eie.3_Missense_Mutation_p.I63V|ARMCX2_uc004eif.3_Missense_Mutation_p.I63V|ARMCX2_uc004eig.3_Missense_Mutation_p.I63V|ARMCX2_uc010nnt.2_Missense_Mutation_p.I63V	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	63						integral to membrane	binding			ovary(6)	6						CCAAGGTCGATTGTGAATCCG	0.463													15	59					0	0	0	0	C	100912388	C	C	100912388	3	2	164	1	0	0	0	0	1	0	0	0	962	1493	52	5	1715	5	ARMCX2	23	100912388	Missense_Mutation	SNP	T	TCGA-CR-7399-01A-11D-2012-08	14942728	100912388	54358172	316	30214											
DCX	1641	broad.mit.edu	37	chrX	110644217	110644217	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtactttgaaaaagtacctaCctgttttccatccagagtgt	11	14	7	9	0	0	2	0	1	0	1	2	2	2	2	4	0	3	3	4	0	5	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:110644217C>A	uc004epd.2	-	3	1120	c.948_splice	c.e3+1	p.Q316_splice	DCX_uc011msv.1_Splice_Site_p.Q316_splice|DCX_uc004epe.2_Splice_Site_p.Q235_splice|DCX_uc004epf.2_Splice_Site_p.Q235_splice|DCX_uc004epg.2_Splice_Site_p.Q235_splice	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a						axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						AAAGTACCTACCTGTTTTCCA	0.398													31	116					1.08312e-15	3.08427e-15	1	0	A	110644217	A	A	110644217	5	1	164	1	0	0	0	0	0	0	1	0	4335	521	18	4	411	4	DCX	23	110644217	Splice_Site	SNP	C	TCGA-CR-7399-01A-11D-2012-08	9731829	110644217	44626343	317	30215											
LUZP4	51213	broad.mit.edu	37	chrX	114540770	114540770	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ataattgggatccttttcagGagaagtgcagtgacaattat	13	13	10	5	0	1	2	1	1	0	1	2	4	2	3	1	2	1	1	1	2	4	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:114540770G>T	uc004eqa.2	+	4	377	c.343G>T	c.(343-345)GAG>TAG	p.E115*	LUZP4_uc004eqb.2_Nonsense_Mutation_p.E33*	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	115						nucleus				ovary(2)	2						TCCTTTTCAGGAGAAGTGCAG	0.378													6	32					0.00116845	0.00243214	1	0	T	114540770	T	T	114540770	4	4	164	1	0	0	0	0	0	1	0	0	9138	1188	41	2	357	2	LUZP4	23	114540770	Nonsense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	3896553	114540770	40729790	318	30216											
GPC3	2719	broad.mit.edu	37	chrX	133087117	133087117	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaataattaagaacttgagCtccatacttgcagactgaag	15	11	8	7	0	0	5	0	3	0	2	1	5	1	5	1	0	4	2	1	0	6	5			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:133087117C>A	uc004exe.1	-	2	487	c.297G>T	c.(295-297)GAG>GAT	p.E99D	GPC3_uc010nrn.1_Missense_Mutation_p.E99D|GPC3_uc011mvh.1_Intron|GPC3_uc010nro.1_Intron|GPC3_uc010nrp.1_5'UTR	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	99						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					AGAACTTGAGCTCCATACTTG	0.438			T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				31	174					5.60225e-13	1.57191e-12	1	0	A	133087117	A	A	133087117	3	1	164	1	0	0	0	0	1	0	0	0	6637	796	28	4	1546	4	GPC3	23	133087117	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	18546347	133087117	22183443	319	30217											
MCF2	4168	broad.mit.edu	37	chrX	138708352	138708352	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaaatgttttaactgacCtgttgaaaatcctgctcaaa	16	12	6	7	0	1	3	1	2	0	1	2	3	2	3	2	0	2	3	2	0	6	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:138708352C>A	uc004fau.2	-	6	981	c.687G>T	c.(685-687)CAG>CAT	p.Q229H	MCF2_uc004fav.2_Missense_Mutation_p.Q229H|MCF2_uc011mwl.1_Missense_Mutation_p.Q190H|MCF2_uc010nsh.1_Missense_Mutation_p.Q229H|MCF2_uc011mwm.1_Missense_Mutation_p.Q190H|MCF2_uc011mwn.1_Missense_Mutation_p.Q374H|MCF2_uc004faw.2_Missense_Mutation_p.Q289H|MCF2_uc011mwo.1_Missense_Mutation_p.Q289H	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	229	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TTTAACTGACCTGTTGAAAAT	0.348													11	67					4.68919e-08	1.16621e-07	1	0	A	138708352	A	A	138708352	3	1	164	1	0	0	0	0	1	0	0	0	9431	695	24	4	2250	4	MCF2	23	138708352	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	5621235	138708352	16562208	320	30218											
DNASE1L1	1774	broad.mit.edu	37	chrX	153631469	153631469	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtccgcagctccagcttGtccaggcgctttttggtcag	5	12	11	13	2	2	0	2	0	0	0	5	0	5	0	3	2	2	4	3	2	0	3			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:153631469G>T	uc004fks.1	-	7	779	c.588C>A	c.(586-588)GAC>GAA	p.D196E	RPL10_uc004fkq.1_Intron|RPL10_uc004fkr.1_Intron|DNASE1L1_uc004fkt.1_Missense_Mutation_p.D196E|DNASE1L1_uc004fku.1_Missense_Mutation_p.D196E|DNASE1L1_uc004fkv.1_Missense_Mutation_p.D196E|DNASE1L1_uc004fkw.1_Missense_Mutation_p.D196E	NM_006730	NP_006721	P49184	DNSL1_HUMAN	deoxyribonuclease I-like 1 precursor	196					DNA catabolic process	endoplasmic reticulum	DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTCCAGCTTGTCCAGGCGCT	0.622													22	67					6.44725e-10	1.70886e-09	1	0	T	153631469	T	T	153631469	3	4	164	1	0	0	0	0	1	0	0	0	4683	1368	48	4	328	4	DNASE1L1	23	153631469	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	14923117	153631469	1639091	321	30219											
PLXNA3	55558	broad.mit.edu	37	chrX	153695707	153695707	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaccacgtgcaaacggccCgctccctcaaccgctcctcc	7	6	8	20	4	1	0	1	0	0	0	4	1	4	1	6	2	3	3	6	2	2	0			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:153695707C>T	uc004flm.2	+	19	3507	c.3334C>T	c.(3334-3336)CGC>TGC	p.R1112C		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1112	IPT/TIG 3.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCAAACGGCCCGCTCCCTCAA	0.652													9	57					0	0	0	0	T	153695707	T	T	153695707	3	4	164	1	0	0	0	0	1	0	0	0	12176	652	23	1	3404	1	PLXNA3	23	153695707	Missense_Mutation	SNP	C	TCGA-CR-7399-01A-11D-2012-08	64238	153695707	1574853	322	30220											
TMLHE	55217	broad.mit.edu	37	chrX	154736700	154736700	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagttcaaattcctcaggtGccttttgaagtacctgttct	8	15	9	9	0	3	1	2	1	1	0	4	2	4	2	3	2	2	3	3	2	3	6			TCGA-CR-7399-01A-11D-2012-08	TCGA-CR-7399-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	0a76ba15-f6e5-484f-8a52-9be8351ebdb7	56cff3ff-2ff4-407f-9eae-6b56d8f2f214	g.chrX:154736700G>T	uc004fnn.2	-	6	1020	c.854C>A	c.(853-855)GCA>GAA	p.A285E	TMLHE_uc004fno.2_Missense_Mutation_p.A285E|TMLHE_uc004fnp.3_Missense_Mutation_p.A285E	NM_018196	NP_060666	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	285					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	TTCCTCAGGTGCCTTTTGAAG	0.418													39	104					1.03484e-13	2.91428e-13	1	0	T	154736700	T	T	154736700	3	4	164	1	0	0	0	0	1	0	0	0	16298	1319	46	4	563	4	TMLHE	23	154736700	Missense_Mutation	SNP	G	TCGA-CR-7399-01A-11D-2012-08	1040993	154736700	533860	323	30221											
ZMYM6	9204	broad.mit.edu	37	chr1	35484994	35484994	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcttgggaggaggtggcaGgcaggcaggtgaagaatgtc	9	9	18	5	0	1	2	0	1	1	1	2	4	1	4	0	7	0	3	0	7	2	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:35484994G>A	uc001byh.2	-	4	616	c.388C>T	c.(388-390)CTG>TTG	p.L130L	ZMYM6_uc001byf.1_Silent_p.L130L|ZMYM6_uc010oht.1_Silent_p.L33L|ZMYM6_uc009vup.2_Intron|ZMYM6_uc009vuq.1_Silent_p.L130L|ZMYM6_uc009vur.1_Intron|ZMYM6_uc001byj.2_Silent_p.L130L|ZMYM6_uc001byi.2_Silent_p.L130L|ZMYM6_uc001byk.2_Silent_p.L130L	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	130	MYM-type 1.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GGAGGTGGCAGGCAGGCAGGT	0.403													14	42					0	0	0	0	A	35484994	A	A	35484994	2	1	165	1	0	0	0	0	0	0	0	1	17771	991	35	4		4	ZMYM6	1	35484994	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08		35484994	213765627	1	30222											
INADL	10207	broad.mit.edu	37	chr1	62263043	62263043	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggtggtacacctaaccCtagttcgaaggaagacatcc	12	7	11	11	1	0	1	0	0	0	1	2	3	1	2	3	4	2	3	3	4	5	4	rs145732252		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:62263043C>G	uc001dab.2	+	11	1459	c.1345C>G	c.(1345-1347)CTA>GTA	p.L449V	INADL_uc009waf.1_Missense_Mutation_p.L449V|INADL_uc001daa.2_Missense_Mutation_p.L449V|INADL_uc001dad.3_Missense_Mutation_p.L146V	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	449	PDZ 3.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						ACACCTAACCCTAGTTCGAAG	0.443													27	96					0	0	0	0	G	62263043	G	G	62263043	3	3	165	1	0	0	0	0	1	0	0	0	7770	680	24	4	1383	4	INADL	1	62263043	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	26778049	62263043	186987578	2	30223											
PIGK	10026	broad.mit.edu	37	chr1	77558060	77558061	+	Frame_Shift_Ins	INS	-	A	A																															cttcattcatcatcaagtctINSaaaaaatgaacttcatatgc																										TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:77558060_77558061insA	uc001dhk.2	-	11	1231_1232	c.1186_1187insT	c.(1186-1188)TAGfs	p.*396fs	PIGK_uc010orj.1_Frame_Shift_Ins_p.*320fs|PIGK_uc009wbx.2_Frame_Shift_Ins_p.*302fs	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	396					attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						TCATCAAGTCTAAAAAATGAAC	0.327													---	---	---								A	77558061	A	A	77558060	7	5	165	1	0	1	1	0	0	0	0	0	11945	1535	53	0	4	0	PIGK	1	77558060	Frame_Shift_Ins	INS	-	TCGA-CR-7401-01A-11D-2012-08	15295017	77558060	171692561	3	30224											
ARHGEF2	9181	broad.mit.edu	37	chr1	155924729	155924729	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaagcctcatcctctgtctCaatcagggggaagtcctccc	8	10	9	14	0	4	0	3	0	2	0	8	1	7	1	4	2	1	1	4	2	3	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:155924729C>G	uc001fmt.2	-	14	1865	c.1747G>C	c.(1747-1749)GAG>CAG	p.E583Q	ARHGEF2_uc001fmr.2_Missense_Mutation_p.E555Q|ARHGEF2_uc001fms.2_Missense_Mutation_p.E582Q|ARHGEF2_uc001fmu.2_Missense_Mutation_p.E627Q	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2	583					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					TCCTCTGTCTCAATCAGGGGG	0.368													14	71					0	0	0	0	G	155924729	G	G	155924729	3	3	165	1	0	0	0	0	1	0	0	0	903	835	29	2	1249	2	ARHGEF2	1	155924729	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	78366669	155924729	93325892	4	30225											
KIF14	9928	broad.mit.edu	37	chr1	200550381	200550381	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgatagcattggcttcctGaatcatcattgagagtttca	10	14	9	8	0	3	3	3	3	0	1	4	4	4	3	1	1	1	4	1	1	2	5			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:200550381G>A	uc010ppk.1	-	20	3722	c.3283C>T	c.(3283-3285)CAG>TAG	p.Q1095*	KIF14_uc010ppj.1_Nonsense_Mutation_p.Q604*	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1095	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TTGGCTTCCTGAATCATCATT	0.338													9	68					0	0	0	0	A	200550381	A	A	200550381	4	1	165	1	0	0	0	0	0	1	0	0	8315	1299	45	2	1707	2	KIF14	1	200550381	Nonsense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	44625652	200550381	48700240	5	30226											
LYST	1130	broad.mit.edu	37	chr1	235940477	235940477	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgatgaggttctaataagatGctctgaacttcttttgagct	10	16	9	6	0	3	5	0	4	3	1	3	5	3	5	0	1	3	3	0	1	3	6			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr1:235940477G>A	uc001hxj.2	-	17	5521	c.5346C>T	c.(5344-5346)AGC>AGT	p.S1782S	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1782					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CTAATAAGATGCTCTGAACTT	0.378									Chediak-Higashi_syndrome				21	84					0	0	0	0	A	235940477	A	A	235940477	2	1	165	1	0	0	0	0	0	0	0	1	9179	1310	46	4		4	LYST	1	235940477	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	35390096	235940477	13310144	6	30227											
DPYSL5	56896	broad.mit.edu	37	chr2	27121505	27121505	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgagctcatgatccctggCggggccaaggtgattgatgc	7	8	15	11	3	1	3	1	3	0	0	2	4	2	3	2	4	2	1	2	4	1	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:27121505C>T	uc002rhu.3	+	2	296	c.138C>T	c.(136-138)GGC>GGT	p.G46G	DPYSL5_uc002rhv.3_Silent_p.G46G	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	46					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATCCCTGGCGGGGCCAAGG	0.592													14	57					0	0	0	0	T	27121505	T	T	27121505	2	4	165	1	0	0	0	0	0	0	0	1	4772	755	27	1		1	DPYSL5	2	27121505	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08		27121505	216077868	7	30228											
CCDC85A	114800	broad.mit.edu	37	chr2	56420319	56420319	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagggagcagccctgaacaCgccaggcacagtggagggag	11	3	16	11	1	1	1	1	1	0	0	1	4	1	4	2	4	3	2	2	4	1	0			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:56420319C>T	uc002rzn.2	+	2	1486	c.984C>T	c.(982-984)CAC>CAT	p.H328H		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	328	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCCCTGAACACGCCAGGCACA	0.662													11	112					0	0	0	0	T	56420319	T	T	56420319	2	4	165	1	0	0	0	0	0	0	0	1	2872	535	19	1		1	CCDC85A	2	56420319	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08	29298814	56420319	186779054	8	30229											
POLR1B	84172	broad.mit.edu	37	chr2	113331325	113331325	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtttataggagcaaaactgCagtacggagatccgtattac	13	10	10	8	3	0	1	0	0	0	1	1	3	1	2	1	2	5	5	1	2	7	6			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:113331325C>T	uc002thw.2	+	14	3038	c.2458C>T	c.(2458-2460)CAG>TAG	p.Q820*	POLR1B_uc010fkn.2_Nonsense_Mutation_p.Q764*|POLR1B_uc002thx.2_Nonsense_Mutation_p.Q681*|POLR1B_uc010fko.2_Nonsense_Mutation_p.Q637*|POLR1B_uc010fkp.2_Nonsense_Mutation_p.Q259*|POLR1B_uc010yxn.1_Nonsense_Mutation_p.Q858*|POLR1B_uc002thy.2_Nonsense_Mutation_p.Q681*|POLR1B_uc010yxo.1_Nonsense_Mutation_p.Q597*	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	820					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						AGCAAAACTGCAGTACGGAGA	0.438													19	105					0	0	0	0	T	113331325	T	T	113331325	4	4	165	1	0	0	0	0	0	1	0	0	12265	711	25	4	2512	4	POLR1B	2	113331325	Nonsense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	56911006	113331325	129868048	9	30230											
CPO	130749	broad.mit.edu	37	chr2	207824389	207824389	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaagacaactcaagtatacGcaagctccttaggaacctgg	15	8	8	10	1	1	1	1	0	0	1	2	2	2	2	2	2	4	3	2	2	9	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:207824389G>A	uc002vby.2	+	5	453	c.407G>A	c.(406-408)CGC>CAC	p.R136H		NM_173077	NP_775100	Q8IVL8	CBPO_HUMAN	carboxypeptidase O precursor	136					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		TCAAGTATACGCAAGCTCCTT	0.353													4	46					0	0	0	0	A	207824389	A	A	207824389	3	1	165	1	0	0	0	0	1	0	0	0	3835	1087	38	1	425	1	CPO	2	207824389	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	94493064	207824389	35374984	10	30231											
ERBB4	2066	broad.mit.edu	37	chr2	212495211	212495211	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtttccaagaatcttctcaaGgctcttttctttttgatgct	7	19	6	9	0	4	2	1	1	4	1	6	2	5	2	1	1	1	3	1	1	3	6			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:212495211G>A	uc002veg.1	-	17	2153	c.2055C>T	c.(2053-2055)GCC>GCT	p.A685A	ERBB4_uc002veh.1_Silent_p.A685A|ERBB4_uc010zji.1_Silent_p.A675A|ERBB4_uc010zjj.1_Silent_p.A675A|ERBB4_uc010fut.1_Silent_p.A685A	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	685	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATCTTCTCAAGGCTCTTTTCT	0.393										TSP Lung(8;0.080)			14	80					0	0	0	0	A	212495211	A	A	212495211	2	1	165	1	0	0	0	0	0	0	0	1	5233	987	35	4		4	ERBB4	2	212495211	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	4670822	212495211	30704162	11	30232											
TNS1	7145	broad.mit.edu	37	chr2	218713727	218713727	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtgtggcattaacagcccCggtgctgccgtgcagggagt	7	8	15	11	3	0	0	0	0	0	0	0	1	0	1	3	3	5	3	3	3	1	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:218713727C>T	uc002vgt.2	-	17	1536	c.1138G>A	c.(1138-1140)GGG>AGG	p.G380R	TNS1_uc002vgr.2_Missense_Mutation_p.G380R|TNS1_uc002vgs.2_Missense_Mutation_p.G380R|TNS1_uc010zjv.1_Missense_Mutation_p.G380R|TNS1_uc010fvj.1_Missense_Mutation_p.G448R|TNS1_uc010fvk.1_Missense_Mutation_p.G505R|TNS1_uc010fvi.1_Missense_Mutation_p.G67R	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	380						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TTAACAGCCCCGGTGCTGCCG	0.607													41	163					0	0	0	0	T	218713727	T	T	218713727	3	4	165	1	0	0	0	0	1	0	0	0	16409	652	23	1	4137	1	TNS1	2	218713727	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	6218516	218713727	24485646	12	30233											
C2orf83	56918	broad.mit.edu	37	chr2	228476326	228476326	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catgtctgtacggtaagtttCctcatccctgggtcccaagg	7	12	10	12	1	2	0	1	0	1	0	5	0	5	0	3	3	1	3	3	3	3	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:228476326C>T	uc002vph.2	-	3	472	c.237G>A	c.(235-237)AGG>AGA	p.R79R	C2orf83_uc010zlu.1_3'UTR	NM_020161	NP_064546	Q53S99	CB083_HUMAN	hypothetical protein LOC56918 isoform 1	79						membrane	folic acid binding|reduced folate carrier activity				0						CGGTAAGTTTCCTCATCCCTG	0.468													18	65					0	0	0	0	T	228476326	T	T	228476326	2	4	165	1	0	0	0	0	0	0	0	1	2208	854	30	2		2	C2orf83	2	228476326	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08	9762599	228476326	14723047	13	30234											
SP140L	93349	broad.mit.edu	37	chr2	231264899	231264899	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggggagctgttctgttgcGacacttgttcaagagtcttc	7	13	13	8	1	3	1	1	0	2	1	4	4	3	2	0	2	2	4	0	2	1	5			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:231264899G>A	uc010fxm.1	+	15	1346	c.1255G>A	c.(1255-1257)GAC>AAC	p.D419N	SP140L_uc010fxo.1_Missense_Mutation_p.D191N	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	419	PHD-type; degenerate.					nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1						GTTCTGTTGCGACACTTGTTC	0.498													21	79					0	0	0	0	A	231264899	A	A	231264899	3	1	165	1	0	0	0	0	1	0	0	0	15027	1058	37	1	1313	1	SP140L	2	231264899	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	2788573	231264899	11934474	14	30235											
KLHL30	377007	broad.mit.edu	37	chr2	239049729	239049729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctgacacgcacggctgcgCgcctgcacttcccctcggtg	4	7	12	18	6	0	1	0	1	0	0	2	1	1	1	3	2	2	4	3	2	0	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr2:239049729C>T	uc002vxr.1	+	1	313	c.280C>T	c.(280-282)CGC>TGC	p.R94C		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	112											0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CACGGCTGCGCGCCTGCACTT	0.667													18	81					0	0	0	0	T	239049729	T	T	239049729	3	4	165	1	0	0	0	0	1	0	0	0	8423	768	27	1	336	1	KLHL30	2	239049729	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	7784830	239049729	4149644	15	30236											
C3orf23	285343	broad.mit.edu	37	chr3	44399311	44399311	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgaagcagtcaatgccttGaggcctttctattttgcagt	8	14	10	9	0	2	2	1	2	1	0	2	2	2	2	2	1	3	3	2	1	3	5			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:44399311G>C	uc010him.2	+	3	353	c.108G>C	c.(106-108)TTG>TTC	p.L36F	C3orf23_uc003cnd.3_Missense_Mutation_p.L36F|C3orf23_uc003cne.3_5'UTR|C3orf23_uc003cnb.3_Missense_Mutation_p.L36F|C3orf23_uc003cnc.3_Missense_Mutation_p.L36F	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	36						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		TCAATGCCTTGAGGCCTTTCT	0.388													6	24					0	0	0	0	C	44399311	C	C	44399311	3	2	165	1	0	0	0	0	1	0	0	0	2226	1281	45	2	114	2	C3orf23	3	44399311	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08		44399311	153623119	16	30237											
TMEM115	11070	broad.mit.edu	37	chr3	50392907	50392907	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagactcctcttcatcatcaTccatgctgggccagatggac	9	10	8	14	0	4	2	3	0	1	2	6	3	6	3	3	2	1	1	3	2	0	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:50392907T>C	uc003dan.1	-	2	1368	c.923A>G	c.(922-924)GAT>GGT	p.D308G		NM_007024	NP_008955	Q12893	TM115_HUMAN	PL6 protein	308					negative regulation of cell proliferation	Golgi apparatus|integral to membrane|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TTCATCATCATCCATGCTGGG	0.607													9	36					0	0	0	0	C	50392907	C	C	50392907	3	2	165	1	0	0	0	0	1	0	0	0	16095	1435	50	5	136	5	TMEM115	3	50392907	Missense_Mutation	SNP	T	TCGA-CR-7401-01A-11D-2012-08	5993596	50392907	147629523	17	30238											
EPHA3	2042	broad.mit.edu	37	chr3	89478308	89478308	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagaatggttccttggatagTttcctacgtgtaagtaagat	11	14	11	5	1	0	2	0	0	0	2	2	4	2	3	2	2	1	4	2	2	5	7			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:89478308T>C	uc003dqy.2	+	12	2352	c.2127T>C	c.(2125-2127)AGT>AGC	p.S709S	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	709	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CCTTGGATAGTTTCCTACGTG	0.323										TSP Lung(6;0.00050)			12	34					0	0	0	0	C	89478308	C	C	89478308	2	2	165	1	0	0	0	0	0	0	0	1	5192	1722	60	5		5	EPHA3	3	89478308	Silent	SNP	T	TCGA-CR-7401-01A-11D-2012-08	39085401	89478308	108544122	18	30239											
EPHA6	285220	broad.mit.edu	37	chr3	96706230	96706230	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccattcacacataccaggtAtgtaatgtaatggaaccaaa	16	9	6	10	0	1	0	1	0	0	0	1	1	1	1	3	2	2	3	3	2	6	5			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:96706230A>G	uc010how.1	+	3	550	c.507A>G	c.(505-507)GTA>GTG	p.V169V	EPHA6_uc003drp.1_Silent_p.V169V	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	74	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CATACCAGGTATGTAATGTAA	0.378													16	127					0	0	0	0	G	96706230	G	G	96706230	2	3	165	1	0	0	0	0	0	0	0	1	5195	436	16	5		5	EPHA6	3	96706230	Silent	SNP	A	TCGA-CR-7401-01A-11D-2012-08	7227922	96706230	101316200	19	30240											
EIF2A	83939	broad.mit.edu	37	chr3	150264529	150264529	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccacgcatgaggagacgtGtaggggccgggttcggccct	6	7	16	12	4	0	2	0	1	0	1	2	3	1	2	3	5	0	3	3	5	1	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:150264529G>A	uc003eya.2	+						SERP1_uc003exy.2_5'Flank|SERP1_uc003exz.2_RNA|EIF2A_uc003eyb.2_5'Flank|EIF2A_uc003eyc.2_5'Flank|EIF2A_uc011bnv.1_5'Flank|EIF2A_uc011bnw.1_5'Flank	NM_032025	NP_114414	Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A						regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding				0		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GAGGAGACGTGTAGGGGCCGG	0.612													23	57					0	0	0	0	A	150264529	A	A	150264529	1	1	165	0	1	0	0	0	0	0	0	0	5017	1392	48	4		4	EIF2A	3	150264529	5'Flank	SNP	G	TCGA-CR-7401-01A-11D-2012-08	53558299	150264529	47757901	20	30241											
PIK3CA	5290	broad.mit.edu	37	chr3	178921549	178921549	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattctttgtgcaacctacgTgaatgtaaatattcgagaca	14	13	7	7	2	1	2	0	1	1	1	2	3	1	2	1	0	3	2	1	0	7	6			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:178921549T>G	uc003fjk.2	+	5	1188	c.1031T>G	c.(1030-1032)GTG>GGG	p.V344G		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	344					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.V344A(1)|p.V344G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GCAACCTACGTGAATGTAAAT	0.303		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			9	44					0	0	0	0	G	178921549	G	G	178921549	3	3	165	1	0	0	0	0	1	0	0	0	11968	1696	59	5	1045	5	PIK3CA	3	178921549	Missense_Mutation	SNP	T	TCGA-CR-7401-01A-11D-2012-08	28657020	178921549	19100881	21	30242											
MCF2L2	23101	broad.mit.edu	37	chr3	183041051	183041051	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttacccactgaccgtggCgatattccaaagtcccccct	9	10	7	15	2	0	1	0	1	0	0	2	3	2	1	6	1	1	0	6	1	3	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr3:183041051C>T	uc003fli.1	-	6	665	c.575G>A	c.(574-576)CGC>CAC	p.R192H	MCF2L2_uc003flj.1_Missense_Mutation_p.R192H|MCF2L2_uc003flp.1_Missense_Mutation_p.R227H	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	192	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CTGACCGTGGCGATATTCCAA	0.488													23	79					0	0	0	0	T	183041051	T	T	183041051	3	4	165	1	0	0	0	0	1	0	0	0	9433	768	27	1	2869	1	MCF2L2	3	183041051	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	4119502	183041051	14981379	22	30243											
JAKMIP1	152789	broad.mit.edu	37	chr4	6058428	6058428	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtggggtcacgcacctttTccagcaagtcttggtttgtt	6	14	12	9	1	2	0	1	0	1	0	3	0	3	0	2	4	1	4	2	4	1	5			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:6058428T>C	uc003giu.3	-	12	1979	c.1703A>G	c.(1702-1704)GAA>GGA	p.E568G	JAKMIP1_uc010idb.1_Missense_Mutation_p.E568G|JAKMIP1_uc010idc.1_Missense_Mutation_p.E383G|JAKMIP1_uc010idd.1_Intron|JAKMIP1_uc011bwc.1_Missense_Mutation_p.E403G|JAKMIP1_uc003giv.3_Missense_Mutation_p.E568G|JAKMIP1_uc010ide.2_Missense_Mutation_p.E568G	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	568	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						ACGCACCTTTTCCAGCAAGTC	0.542													18	72					0	0	0	0	C	6058428	C	C	6058428	3	2	165	1	0	0	0	0	1	0	0	0	7979	1783	62	5	907	5	JAKMIP1	4	6058428	Missense_Mutation	SNP	T	TCGA-CR-7401-01A-11D-2012-08		6058428	185095848	23	30244											
YTHDC1	91746	broad.mit.edu	37	chr4	69203343	69203343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctttcaggatcccttttccGgacacaggttttttcaggtt	6	16	8	11	1	2	0	2	0	0	0	4	2	4	2	3	4	0	2	3	4	0	7			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:69203343G>A	uc003hdx.2	-	3	759	c.406C>T	c.(406-408)CGG>TGG	p.R136W	YTHDC1_uc003hdy.2_Missense_Mutation_p.R136W	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	136										upper_aerodigestive_tract(1)|ovary(1)	2						TCCCTTTTCCGGACACAGGTT	0.403													5	43					0	0	0	0	A	69203343	A	A	69203343	3	1	165	1	0	0	0	0	1	0	0	0	17564	1115	39	1	1837	1	YTHDC1	4	69203343	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	63144915	69203343	121950933	24	30245											
SLC4A4	8671	broad.mit.edu	37	chr4	72215743	72215743	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacatgtatggagaaaggAtccatcatgcttgatcggga	13	9	13	6	1	1	2	1	1	0	1	3	6	2	5	1	4	1	2	1	4	2	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:72215743A>T	uc003hfy.2	+	5	621	c.504A>T	c.(502-504)GGA>GGT	p.G168G	SLC4A4_uc010iic.2_Silent_p.G168G|SLC4A4_uc010iib.2_Silent_p.G168G|SLC4A4_uc003hfz.2_Silent_p.G168G|SLC4A4_uc003hgc.3_Silent_p.G124G|SLC4A4_uc003hga.2_Silent_p.G46G|SLC4A4_uc003hgb.3_Silent_p.G124G	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	168	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TGGAGAAAGGATCCATCATGC	0.453													15	70					0	0	0	0	T	72215743	T	T	72215743	2	4	165	1	0	0	0	0	0	0	0	1	14720	320	12	5		5	SLC4A4	4	72215743	Silent	SNP	A	TCGA-CR-7401-01A-11D-2012-08	3012400	72215743	118938533	25	30246											
PRSS12	8492	broad.mit.edu	37	chr4	119219987	119219987	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttccaatatcttgcttgaTacagtcagccaaggacctct	10	13	6	12	0	4	1	1	1	3	0	5	2	5	2	3	1	3	1	3	1	4	5			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:119219987T>C	uc003ica.1	-	9	1785	c.1738A>G	c.(1738-1740)ATC>GTC	p.I580V		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	580	SRCR 4.					membrane	scavenger receptor activity			skin(1)	1						TCTTGCTTGATACAGTCAGCC	0.448													12	63					0	0	0	0	C	119219987	C	C	119219987	3	2	165	1	0	0	0	0	1	0	0	0	12677	1406	49	5	909	5	PRSS12	4	119219987	Missense_Mutation	SNP	T	TCGA-CR-7401-01A-11D-2012-08	47004244	119219987	71934289	26	30247											
FAT4	79633	broad.mit.edu	37	chr4	126242740	126242740	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagaacacagagagcagAggtaatgattttgtagtcat	14	10	10	7	0	1	4	1	1	0	3	2	5	2	4	1	1	2	3	1	1	3	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:126242740A>G	uc003ifj.3	+	1	5174	c.5174A>G	c.(5173-5175)GAG>GGG	p.E1725G		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1725	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CAGAGAGCAGAGGTAATGATT	0.353													8	28					0	0	0	0	G	126242740	G	G	126242740	3	3	165	1	0	0	0	0	1	0	0	0	5724	318	11	5	5176	5	FAT4	4	126242740	Missense_Mutation	SNP	A	TCGA-CR-7401-01A-11D-2012-08	7022753	126242740	64911536	27	30248											
FAT4	79633	broad.mit.edu	37	chr4	126412581	126412581	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatatacttccagaatgccCaaattatctcaagtcaatga	15	12	5	9	0	2	2	2	1	1	1	4	2	3	2	2	0	2	1	2	0	8	5			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr4:126412581C>A	uc003ifj.3	+	17	14604	c.14604C>A	c.(14602-14604)CCC>CCA	p.P4868P	FAT4_uc011cgp.1_Silent_p.P3109P|FAT4_uc003ifi.1_Silent_p.P2345P	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4868	Cytoplasmic (Potential).			P -> S (in Ref. 4; BAB15534).	homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCAGAATGCCCAAATTATCTC	0.458													17	46					3.52763e-06	3.86902e-06	1	0	A	126412581	A	A	126412581	2	1	165	1	0	0	0	0	0	0	0	1	5724	581	21	4		4	FAT4	4	126412581	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08	169841	126412581	64741695	28	30249											
GZMK	3003	broad.mit.edu	37	chr5	54320494	54320494	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtctacttttgtaggtttcaAtatggaaattattggaggga	11	16	11	3	0	2	0	1	0	1	0	2	3	2	3	0	4	1	2	0	4	6	8			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr5:54320494A>T	uc003jpl.1	+	2	115	c.71A>T	c.(70-72)AAT>ATT	p.N24I		NM_002104	NP_002095	P49863	GRAK_HUMAN	granzyme K precursor	24					proteolysis	extracellular region	serine-type endopeptidase activity				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				GTAGGTTTCAATATGGAAATT	0.383													7	19					0	0	0	0	T	54320494	T	T	54320494	3	4	165	1	0	0	0	0	1	0	0	0	6957	101	4	5	77	5	GZMK	5	54320494	Missense_Mutation	SNP	A	TCGA-CR-7401-01A-11D-2012-08		54320494	126594766	29	30250											
FSTL4	23105	broad.mit.edu	37	chr5	132652310	132652310	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgccagaaggacattcttCaagcgggcgtagccggccat	10	7	13	11	3	2	1	1	0	1	1	2	2	2	2	3	3	3	1	3	3	3	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr5:132652310C>T	uc003kyn.1	-	5	662	c.444G>A	c.(442-444)TTG>TTA	p.L148L		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	148						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGACATTCTTCAAGCGGGCGT	0.547											OREG0016777	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	80					0	0	0	0	T	132652310	T	T	132652310	2	4	165	1	0	0	0	0	0	0	0	1	6113	825	29	2		2	FSTL4	5	132652310	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08	78331816	132652310	48262950	30	30251											
PCDHGB1	56104	broad.mit.edu	37	chr5	140731697	140731697	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgcacgggtgaggtgcgcAcagcgcgtgccttgggcgac	5	6	18	12	6	0	1	0	1	0	0	0	2	0	1	1	3	4	2	1	3	0	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr5:140731697A>C	uc003ljo.1	+	1	1870	c.1870A>C	c.(1870-1872)ACA>CCA	p.T624P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.T624P	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	624	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGGTGCGCACAGCGCGTGC	0.706													9	57					0	0	0	0	C	140731697	C	C	140731697	3	2	165	1	0	0	0	0	1	0	0	0	11616	159	6	5	1872	5	PCDHGB1	5	140731697	Missense_Mutation	SNP	A	TCGA-CR-7401-01A-11D-2012-08	8079387	140731697	40183563	31	30252											
HIST1H2BI	8346	broad.mit.edu	37	chr6	26273547	26273547	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caaacacgcggtgtcggaggGcaccaaggcggtcaccaagt	11	4	14	12	4	1	0	1	0	0	0	2	1	1	1	2	5	1	1	2	5	3	0			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:26273547G>A	uc003nhk.2	+	1	344	c.344G>A	c.(343-345)GGC>GAC	p.G115D	HIST1H3G_uc003nhi.2_5'Flank	NM_003525	NP_003516	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	115					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						GTGTCGGAGGGCACCAAGGCG	0.567													15	55					0	0	0	0	A	26273547	A	A	26273547	3	1	165	1	0	0	0	0	1	0	0	0	7187	1203	42	4	346	4	HIST1H2BI	6	26273547	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08		26273547	144841520	32	30253											
MAPK14	1432	broad.mit.edu	37	chr6	36020563	36020563	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcattcatgcgaaaagaacCtacagagaactgcggttact	15	9	8	9	2	2	2	2	0	0	2	2	4	2	2	1	1	6	1	1	1	6	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:36020563C>T	uc003olp.2	+	2	685	c.204C>T	c.(202-204)ACC>ACT	p.T68T	MAPK14_uc011dth.1_Silent_p.T68T|MAPK14_uc003olo.2_Silent_p.T68T|MAPK14_uc003olq.2_Silent_p.T68T|MAPK14_uc003olr.2_Silent_p.T68T|MAPK14_uc011dti.1_5'UTR	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1	68	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						CGAAAAGAACCTACAGAGAAC	0.378													8	36					0	0	0	0	T	36020563	T	T	36020563	2	4	165	1	0	0	0	0	0	0	0	1	9329	668	24	4		4	MAPK14	6	36020563	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08	9747016	36020563	135094504	33	30254											
LAMA2	3908	broad.mit.edu	37	chr6	129687384	129687384	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgtggagatgagtgcactGgccttcttctcggtgacttg	5	15	13	8	1	2	3	0	2	2	1	3	4	2	3	1	3	1	1	1	3	0	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:129687384G>A	uc003qbn.2	+	33	4843	c.4738G>A	c.(4738-4740)GGC>AGC	p.G1580S	LAMA2_uc003qbo.2_Missense_Mutation_p.G1580S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1580	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGAGTGCACTGGCCTTCTTCT	0.468													11	88					0	0	0	0	A	129687384	A	A	129687384	3	1	165	1	0	0	0	0	1	0	0	0	8646	1348	47	4	4868	4	LAMA2	6	129687384	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	93666821	129687384	41427683	34	30255											
TAAR6	319100	broad.mit.edu	37	chr6	132891604	132891604	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggctgtgctggctgtgttTggaaacctcctggtgatgat	5	13	16	7	0	0	2	0	2	0	0	1	3	1	3	2	5	2	4	2	5	1	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr6:132891604T>C	uc011eck.1	+	1	144	c.144T>C	c.(142-144)TTT>TTC	p.F48F		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	48	Helical; Name=1; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TGGCTGTGTTTGGAAACCTCC	0.527													18	110					0	0	0	0	C	132891604	C	C	132891604	2	2	165	1	0	0	0	0	0	0	0	1	15558	1809	63	5		5	TAAR6	6	132891604	Silent	SNP	T	TCGA-CR-7401-01A-11D-2012-08	3204220	132891604	38223463	35	30256											
ZNF804B	219578	broad.mit.edu	37	chr7	88963951	88963951	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaaaaattccagaggaaatAtaatttggactacagtgatt	17	11	9	4	0	0	2	0	1	0	1	1	5	1	5	1	3	1	0	1	3	6	6			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:88963951A>G	uc011khi.1	+	4	2193	c.1655A>G	c.(1654-1656)TAT>TGT	p.Y552C		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	552						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CAGAGGAAATATAATTTGGAC	0.343										HNSCC(36;0.09)			4	40					0	0	0	0	G	88963951	G	G	88963951	3	3	165	1	0	0	0	0	1	0	0	0	18238	449	16	5	1669	5	ZNF804B	7	88963951	Missense_Mutation	SNP	A	TCGA-CR-7401-01A-11D-2012-08		88963951	70174712	36	30257											
ZNF789	285989	broad.mit.edu	37	chr7	99074083	99074083	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accaggccgtggaagccatgTtcccaccagccagggggaag	10	4	14	13	1	0	0	0	0	0	0	1	2	1	2	6	4	2	1	6	4	2	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:99074083T>G	uc003uqq.1	+	2	223	c.4T>G	c.(4-6)TTC>GTC	p.F2V	ZNF789_uc003uqp.2_Missense_Mutation_p.F2V|ZNF789_uc010lfw.1_5'UTR	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	zinc finger protein 789 isoform 1	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGAAGCCATGTTCCCACCAGC	0.562													7	52					0	0	0	0	G	99074083	G	G	99074083	3	3	165	1	0	0	0	0	1	0	0	0	18227	1725	60	5	6	5	ZNF789	7	99074083	Missense_Mutation	SNP	T	TCGA-CR-7401-01A-11D-2012-08	10110132	99074083	60064580	37	30258											
PIK3CG	5294	broad.mit.edu	37	chr7	106508732	106508732	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacccgacgacacccccggCgccatcctgcagagcttctt	7	7	8	19	4	2	1	1	0	1	1	3	3	3	1	5	1	2	2	5	1	0	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:106508732C>T	uc003vdv.3	+	2	811	c.726C>T	c.(724-726)GGC>GGT	p.G242G	PIK3CG_uc003vdu.2_Silent_p.G242G|PIK3CG_uc003vdw.2_Silent_p.G242G	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	242					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						ACACCCCCGGCGCCATCCTGC	0.527													18	98					0	0	0	0	T	106508732	T	T	106508732	2	4	165	1	0	0	0	0	0	0	0	1	11971	755	27	1		1	PIK3CG	7	106508732	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08	7434649	106508732	52629931	38	30259											
PLXNA4	91584	broad.mit.edu	37	chr7	132192500	132192500	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctgccaagcacggcccccGctttggacaggtaggcagcc	7	6	12	16	2	0	0	0	0	0	0	1	1	1	1	5	4	3	4	5	4	2	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:132192500G>A	uc003vra.3	-	2	1182	c.953C>T	c.(952-954)GCG>GTG	p.A318V	PLXNA4_uc003vrc.2_Missense_Mutation_p.A318V|PLXNA4_uc003vrb.2_Missense_Mutation_p.A318V	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	318	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CACGGCCCCCGCTTTGGACAG	0.582													7	42					0	0	0	0	A	132192500	A	A	132192500	3	1	165	1	0	0	0	0	1	0	0	0	12177	1087	38	1	5169	1	PLXNA4	7	132192500	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	25683768	132192500	26946163	39	30260											
C7orf49	78996	broad.mit.edu	37	chr7	134852541	134852541	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcattcatgcagtacacAgtccttgtcgcagggagtct	8	11	10	12	1	3	0	2	0	1	0	5	1	4	1	2	1	2	3	2	1	1	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr7:134852541A>G	uc003vsl.2	-	3	423	c.156T>C	c.(154-156)ACT>ACC	p.T52T	C7orf49_uc003vsh.2_Intron|C7orf49_uc003vsj.2_Silent_p.T23T|C7orf49_uc003vsk.2_RNA|C7orf49_uc003vsm.2_RNA|C7orf49_uc003vsn.2_Silent_p.T51T|C7orf49_uc003vso.2_5'UTR	NM_024033	NP_076938	Q9BWK5	MRI_HUMAN	modulator of retrovirus infection	52						cytoplasm				large_intestine(1)|ovary(1)	2						TGCAGTACACAGTCCTTGTCG	0.473													3	86					0	0	0	0	G	134852541	G	G	134852541	2	3	165	1	0	0	0	0	0	0	0	1	2409	175	7	5		5	C7orf49	7	134852541	Silent	SNP	A	TCGA-CR-7401-01A-11D-2012-08	2660041	134852541	24286122	40	30261											
USP17L2	377630	broad.mit.edu	37	chr8	11996173	11996173	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcagggagagaagtccgctGgatttcagcaaaagctgcat	12	8	12	9	1	2	1	2	0	0	1	3	4	3	3	1	2	3	4	1	2	3	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:11996173G>T	uc003wvc.1	-	1	97	c.97C>A	c.(97-99)CAG>AAG	p.Q33K	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	33					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						GAAGTCCGCTGGATTTCAGCA	0.527													17	82					1.33834e-09	1.50425e-09	1	0	T	11996173	T	T	11996173	3	4	165	1	0	0	0	0	1	0	0	0	17116	1357	47	4	1499	4	USP17L2	8	11996173	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08		11996173	134367849	41	30262											
BNIP3L	665	broad.mit.edu	37	chr8	26238106	26238106	+	5'Flank	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggatcatgaatcaagtgaacGgctaaaaagttaaacacctc	17	8	8	8	1	2	2	2	2	0	0	3	3	2	3	1	2	2	2	1	2	8	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:26238106G>A	uc003xex.1	+						uc003xew.2_RNA|BNIP3L_uc010luh.1_5'Flank|BNIP3L_uc010lui.1_5'Flank	NM_004331	NP_004322	O60238	BNI3L_HUMAN	BCL2/adenovirus E1B 19kD-interacting protein						apoptosis|defense response to virus|induction of apoptosis|interspecies interaction between organisms|mitochondrial protein catabolic process|negative regulation of survival gene product expression	endoplasmic reticulum|integral to membrane|mitochondrial outer membrane|nuclear envelope	lamin binding|protein heterodimerization activity|protein homodimerization activity				0		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0019)|Epithelial(17;1.59e-12)|all cancers(2;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(2;2.57e-08)|Colorectal(74;0.135)		TCAAGTGAACGGCTAAAAAGT	0.388													4	37					0	0	0	0	A	26238106	A	A	26238106	1	1	165	0	1	0	0	0	0	0	0	0	1482	1131	39	1		1	BNIP3L	8	26238106	5'Flank	SNP	G	TCGA-CR-7401-01A-11D-2012-08	14241933	26238106	120125916	42	30263											
PREX2	80243	broad.mit.edu	37	chr8	69031723	69031723	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataaacaggacaagatacatAgttgccttgagcatcttttc	14	12	7	8	0	1	2	0	1	1	1	2	3	1	3	1	1	4	2	1	1	5	7			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:69031723A>G	uc003xxv.1	+	28	3505	c.3478A>G	c.(3478-3480)AGT>GGT	p.S1160G		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1160					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CAAGATACATAGTTGCCTTGA	0.358													48	55					0	0	0	0	G	69031723	G	G	69031723	3	3	165	1	0	0	0	0	1	0	0	0	12539	420	15	5	3817	5	PREX2	8	69031723	Missense_Mutation	SNP	A	TCGA-CR-7401-01A-11D-2012-08	42793617	69031723	77332299	43	30264											
TSPYL5	85453	broad.mit.edu	37	chr8	98290036	98290036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctttgccccggtttttggCgcgggaggactttcgacccc	3	11	13	14	4	0	0	0	0	0	0	1	3	0	2	5	4	1	1	5	4	0	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:98290036C>T	uc003yhy.2	-	1	141	c.37G>A	c.(37-39)GCC>ACC	p.A13T		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	13					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					CGGTTTTTGGCGCGGGAGGAC	0.692													4	26					0	0	0	0	T	98290036	T	T	98290036	3	4	165	1	0	0	0	0	1	0	0	0	16729	768	27	1	1220	1	TSPYL5	8	98290036	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	29258313	98290036	48073986	44	30265											
SYBU	55638	broad.mit.edu	37	chr8	110587403	110587403	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggctgcaaaatccagctctCtcatgaggcggtttgcatga	10	10	11	10	1	2	2	1	2	1	0	4	2	3	2	1	3	3	5	1	3	2	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:110587403C>T	uc003ynj.3	-	7	1887	c.1724G>A	c.(1723-1725)AGA>AAA	p.R575K	SYBU_uc003yni.3_Missense_Mutation_p.R572K|SYBU_uc003ynk.3_Missense_Mutation_p.R456K|SYBU_uc010mco.2_Missense_Mutation_p.R574K|SYBU_uc003ynl.3_Missense_Mutation_p.R574K|SYBU_uc010mcp.2_Missense_Mutation_p.R575K|SYBU_uc010mcq.2_Missense_Mutation_p.R575K|SYBU_uc003yno.3_Missense_Mutation_p.R456K|SYBU_uc010mcr.2_Missense_Mutation_p.R575K|SYBU_uc003ynm.3_Missense_Mutation_p.R574K|SYBU_uc003ynn.3_Missense_Mutation_p.R574K|SYBU_uc010mcs.2_Missense_Mutation_p.R456K|SYBU_uc010mct.2_Missense_Mutation_p.R575K|SYBU_uc010mcu.2_Missense_Mutation_p.R574K|SYBU_uc003ynp.3_Missense_Mutation_p.R507K|SYBU_uc010mcv.2_Missense_Mutation_p.R575K|SYBU_uc003ynh.3_Missense_Mutation_p.R369K|SYBU_uc011lhw.1_Missense_Mutation_p.R445K	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	575						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						ATCCAGCTCTCTCATGAGGCG	0.552													6	83					0	0	0	0	T	110587403	T	T	110587403	3	4	165	1	0	0	0	0	1	0	0	0	15493	913	32	2	271	2	SYBU	8	110587403	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	12297367	110587403	35776619	45	30266											
LRRC6	23639	broad.mit.edu	37	chr8	133622493	133622493	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggtttcacttctgcaggaagGacaagctgaaatggctgaaa	13	9	12	7	0	2	2	1	2	1	0	2	4	2	4	0	4	2	4	0	4	4	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr8:133622493G>A	uc003ytk.2	-	10	1133	c.1059C>T	c.(1057-1059)GTC>GTT	p.V353V	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	353	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CTGCAGGAAGGACAAGCTGAA	0.418													10	67					0	0	0	0	A	133622493	A	A	133622493	2	1	165	1	0	0	0	0	0	0	0	1	9066	1161	41	2		2	LRRC6	8	133622493	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	23035090	133622493	12741529	46	30267											
PTPRD	5789	broad.mit.edu	37	chr9	8499728	8499728	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctcacataatgcacctgAtatcctcttatctggccatg	10	13	5	13	0	3	1	1	1	2	0	5	1	5	1	4	1	1	1	4	1	3	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:8499728A>G	uc003zkk.2	-	24	2952	c.2241T>C	c.(2239-2241)TAT>TAC	p.Y747Y	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Silent_p.Y747Y|PTPRD_uc003zkm.2_Silent_p.Y734Y|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	747	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AATGCACCTGATATCCTCTTA	0.498										TSP Lung(15;0.13)			16	88					0	0	0	0	G	8499728	G	G	8499728	2	3	165	1	0	0	0	0	0	0	0	1	12864	340	12	5		5	PTPRD	9	8499728	Silent	SNP	A	TCGA-CR-7401-01A-11D-2012-08		8499728	132713703	47	30268											
SVEP1	79987	broad.mit.edu	37	chr9	113308490	113308490	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacatttgcagcttcccattCggtcacagcagtccttgcct	7	12	7	15	1	1	0	1	0	0	0	4	0	3	0	3	1	4	3	3	1	0	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:113308490C>G	uc010mtz.2	-	3	1206	c.869G>C	c.(868-870)CGA>CCA	p.R290P	SVEP1_uc010mua.1_Missense_Mutation_p.R290P|SVEP1_uc004beu.2_Missense_Mutation_p.R290P|SVEP1_uc004bev.2_Missense_Mutation_p.E19Q	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	290					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GCTTCCCATTCGGTCACAGCA	0.443													3	1					0	0	0	0	G	113308490	G	G	113308490	3	3	165	1	0	0	0	0	1	0	0	0	15486	884	31	3	10030	3	SVEP1	9	113308490	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	104808762	113308490	27904941	48	30269											
PTGS1	5742	broad.mit.edu	37	chr9	125154466	125154466	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttccccttatctccttgtAggagagaaggagatggcagc	10	11	11	9	0	1	2	0	0	1	2	3	5	2	3	3	3	1	2	3	3	3	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:125154466A>G	uc004bmg.1	+	11	1580	c.1445_splice	c.e11-2	p.G482_splice	PTGS1_uc011lys.1_Splice_Site_p.G420_splice|PTGS1_uc010mwb.1_Splice_Site_p.G336_splice|PTGS1_uc004bmf.1_Splice_Site_p.G445_splice|PTGS1_uc004bmh.1_Splice_Site_p.G373_splice|PTGS1_uc011lyt.1_Splice_Site_p.G373_splice	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1						cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	ATCTCCTTGTAGGAGAGAAGG	0.488													10	24					0	0	0	0	G	125154466	G	G	125154466	5	3	165	1	0	0	0	0	0	0	1	0	12818	434	15	5	1485	5	PTGS1	9	125154466	Splice_Site	SNP	A	TCGA-CR-7401-01A-11D-2012-08	11845976	125154466	16058965	49	30270											
USP20	10868	broad.mit.edu	37	chr9	132637882	132637882	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacatcgacgacctggtggtCatcctgccccagaacgtctg	8	9	10	14	3	2	1	1	0	1	1	4	3	3	1	4	2	3	0	4	2	2	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:132637882C>T	uc004bys.2	+	21	2473	c.2262C>T	c.(2260-2262)GTC>GTT	p.V754V	USP20_uc004byr.2_Silent_p.V754V|USP20_uc004byt.1_Silent_p.V754V	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	754	DUSP 1.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				ACCTGGTGGTCATCCTGCCCC	0.622													26	61					0	0	0	0	T	132637882	T	T	132637882	2	4	165	1	0	0	0	0	0	0	0	1	17120	813	29	2		2	USP20	9	132637882	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08	7483416	132637882	8575549	50	30271											
LCNL1	401562	broad.mit.edu	37	chr9	139879239	139879239	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtacttggagatgcggAaagggggcctgcggaaccag	9	7	17	8	2	0	1	0	0	0	1	0	4	0	3	2	5	5	2	2	5	3	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr9:139879239A>G	uc004ckh.1	+	3	865	c.271A>G	c.(271-273)AAA>GAA	p.K91E		NM_207510	NP_997393	Q6ZST4	LCNL1_HUMAN	lipocalin-like 1	91							binding				0						GGAGATGCGGAAAGGGGGCCT	0.662													7	9					0	0	0	0	G	139879239	G	G	139879239	3	3	165	1	0	0	0	0	1	0	0	0	8728	247	9	5	281	5	LCNL1	9	139879239	Missense_Mutation	SNP	A	TCGA-CR-7401-01A-11D-2012-08	7241357	139879239	1334192	51	30272											
PIK3C2A	5286	broad.mit.edu	37	chr11	17126756	17126756	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggattgtatttccttagcCactctgcaagtggtttatct	8	16	9	8	0	2	0	0	0	2	0	3	1	3	1	2	2	2	3	2	2	4	6			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:17126756C>T	uc001mmq.3	-	22	3707	c.3641G>A	c.(3640-3642)TGG>TAG	p.W1214*	PIK3C2A_uc009ygu.1_5'UTR|PIK3C2A_uc010rcw.1_Nonsense_Mutation_p.W834*|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1214	PI3K/PI4K.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	TTTCCTTAGCCACTCTGCAAG	0.398													6	27					0	0	0	0	T	17126756	T	T	17126756	4	4	165	1	0	0	0	0	0	1	0	0	11964	595	21	4	1463	4	PIK3C2A	11	17126756	Nonsense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08		17126756	117879760	52	30273											
SERGEF	26297	broad.mit.edu	37	chr11	18028145	18028145	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagtgaactcacctgtgagCataatcgtaaaatcccagcc	13	8	9	11	1	1	2	1	2	0	0	3	3	2	3	3	1	3	2	3	1	4	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:18028145C>A	uc001mnm.2	-	3	425	c.345G>T	c.(343-345)ATG>ATT	p.M115I	SERGEF_uc009yhd.2_RNA|SERGEF_uc001mnn.2_Missense_Mutation_p.M115I|SERGEF_uc010rcz.1_Missense_Mutation_p.M1I|SERGEF_uc001mno.1_Missense_Mutation_p.M1I	NM_012139	NP_036271	Q9UGK8	SRGEF_HUMAN	deafness locus associated putative guanine	115	RCC1 2.				negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1						CACCTGTGAGCATAATCGTAA	0.468													14	86					2.61681e-11	2.96572e-11	1	0	A	18028145	A	A	18028145	3	1	165	1	0	0	0	0	1	0	0	0	14142	710	25	4	1067	4	SERGEF	11	18028145	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	901389	18028145	116978371	53	30274											
OR4X1	390113	broad.mit.edu	37	chr11	48285470	48285470	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggattttcccagaattggAgtgagcagagggtcatttct	9	13	13	6	0	2	3	1	1	1	2	3	5	3	5	1	3	1	1	1	3	1	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:48285470A>G	uc010rht.1	+	1	58	c.58A>G	c.(58-60)AGT>GGT	p.S20G		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						CCAGAATTGGAGTGAGCAGAG	0.453													3	55					0	0	0	0	G	48285470	G	G	48285470	3	3	165	1	0	0	0	0	1	0	0	0	11138	304	11	5	60	5	OR4X1	11	48285470	Missense_Mutation	SNP	A	TCGA-CR-7401-01A-11D-2012-08	30257325	48285470	86721046	54	30275											
MS4A14	84689	broad.mit.edu	37	chr11	60183772	60183772	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccagatcttcaaccagaaaAcactgaacctcaaaaccagc	17	5	4	15	0	3	3	2	1	1	2	3	3	3	3	4	0	5	0	4	0	6	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:60183772A>T	uc001npj.2	+	5	1896	c.1331A>T	c.(1330-1332)AAC>ATC	p.N444I	MS4A14_uc001npi.2_Missense_Mutation_p.N332I|MS4A14_uc001npn.2_Missense_Mutation_p.N182I|MS4A14_uc001npk.2_Missense_Mutation_p.N427I|MS4A14_uc001npl.2_Missense_Mutation_p.N182I|MS4A14_uc001npm.2_Missense_Mutation_p.N182I	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	444	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						CAACCAGAAAACACTGAACCT	0.373													10	51					0	0	0	0	T	60183772	T	T	60183772	3	4	165	1	0	0	0	0	1	0	0	0	9911	43	2	5	1349	5	MS4A14	11	60183772	Missense_Mutation	SNP	A	TCGA-CR-7401-01A-11D-2012-08	11898302	60183772	74822744	55	30276											
TBC1D10C	374403	broad.mit.edu	37	chr11	67176566	67176566	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgggagcccttcgagccatcCcccccgcgcagctgcaggag	6	5	13	17	3	0	0	0	0	0	0	2	3	1	2	5	2	4	3	5	2	0	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:67176566C>T	uc001ola.2	+	9	984	c.955C>T	c.(955-957)CCC>TCC	p.P319S	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_Missense_Mutation_p.P254L|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	319						intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			TCGAGCCATCCCCCCCGCGCA	0.692													4	13					0	0	0	0	T	67176566	T	T	67176566	3	4	165	1	0	0	0	0	1	0	0	0	15666	623	22	4	985	4	TBC1D10C	11	67176566	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	6992794	67176566	67829950	56	30277											
TRPC6	7225	broad.mit.edu	37	chr11	101323814	101323814	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atagcggagacttgagatgtCctgcttaatttccttcagtt	9	15	9	8	1	1	2	1	1	0	2	3	4	3	2	2	1	2	2	2	1	2	6			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:101323814C>G	uc001pgk.3	-	13	3093	c.2668G>C	c.(2668-2670)GAC>CAC	p.D890H	TRPC6_uc009ywy.2_Missense_Mutation_p.D774H	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	890	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CTTGAGATGTCCTGCTTAATT	0.398													8	61					0	0	0	0	G	101323814	G	G	101323814	3	3	165	1	0	0	0	0	1	0	0	0	16650	855	30	2	131	2	TRPC6	11	101323814	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	34147248	101323814	33682702	57	30278											
GUCY1A2	2977	broad.mit.edu	37	chr11	106810420	106810420	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagtggaaagggaaggctctAcagaaggtgttgatgctaat	14	9	14	4	0	1	2	0	1	1	1	1	4	1	4	0	4	2	3	0	4	6	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:106810420A>G	uc001pjg.1	-	4	1362	c.972T>C	c.(970-972)TGT>TGC	p.C324C	GUCY1A2_uc010rvo.1_Silent_p.C324C|GUCY1A2_uc009yxn.1_Silent_p.C324C	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	324					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GGAAGGCTCTACAGAAGGTGT	0.458													9	25					0	0	0	0	G	106810420	G	G	106810420	2	3	165	1	0	0	0	0	0	0	0	1	6932	389	14	5		5	GUCY1A2	11	106810420	Silent	SNP	A	TCGA-CR-7401-01A-11D-2012-08	5486606	106810420	28196096	58	30279											
OPCML	4978	broad.mit.edu	37	chr11	132527154	132527154	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaccacttgtcattcccagcGtagaggatggtgctgcggtt	7	11	13	10	2	1	1	1	0	0	1	2	3	2	2	2	3	3	3	2	3	1	4	rs142071206	byFrequency	TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr11:132527154G>A	uc001qgs.2	-	2	278	c.228C>T	c.(226-228)TAC>TAT	p.Y76Y	OPCML_uc001qgu.2_Silent_p.Y69Y|OPCML_uc010sck.1_Silent_p.Y76Y|OPCML_uc001qgt.2_Silent_p.Y76Y|OPCML_uc010scl.1_Silent_p.Y35Y	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	76	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CATTCCCAGCGTAGAGGATGG	0.542													12	71					0	0	0	0	A	132527154	A	A	132527154	2	1	165	1	0	0	0	0	0	0	0	1	10928	1140	40	1		1	OPCML	11	132527154	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	25716734	132527154	2479362	59	30280											
PLEKHA5	54477	broad.mit.edu	37	chr12	19413942	19413942	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgctttctgacctttgcctCttttattatagaggtaagtt	7	19	8	7	0	2	2	0	1	2	1	2	2	2	2	2	1	2	3	2	1	4	8			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:19413942C>G	uc001reb.2	+	7	683	c.597C>G	c.(595-597)CTC>CTG	p.L199L	PLEKHA5_uc010sie.1_Silent_p.L199L|PLEKHA5_uc001rea.2_Silent_p.L199L|PLEKHA5_uc009zin.2_Intron|PLEKHA5_uc010sif.1_Silent_p.L91L|PLEKHA5_uc010sig.1_Silent_p.L91L|PLEKHA5_uc010sih.1_Silent_p.L91L	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	199	PH.						1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					ACCTTTGCCTCTTTTATTATA	0.303													21	123					0	0	0	0	G	19413942	G	G	19413942	2	3	165	1	0	0	0	0	0	0	0	1	12114	900	32	2		2	PLEKHA5	12	19413942	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08		19413942	114437953	60	30281											
ADAMTS20	80070	broad.mit.edu	37	chr12	43944807	43944807	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggtccgagggccctgcgtCgctctcccaggccccgcgct	3	6	13	19	5	1	0	0	0	1	0	4	1	2	0	5	3	1	2	5	3	0	0			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:43944807C>T	uc010skx.1	-	2	358	c.358G>A	c.(358-360)GAC>AAC	p.D120N		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	120						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GGCCCTGCGTCGCTCTCCCAG	0.662													5	29					0	0	0	0	T	43944807	T	T	43944807	3	4	165	1	0	0	0	0	1	0	0	0	266	884	31	1	5525	1	ADAMTS20	12	43944807	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	24530865	43944807	89907088	61	30282											
MYBPC1	4604	broad.mit.edu	37	chr12	102028349	102028349	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagaatctactgggactactCcaaacattgacatcagatct	15	10	6	10	0	3	3	1	1	2	2	4	4	4	4	1	1	3	0	1	1	5	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:102028349C>T	uc001tii.2	+	7	601	c.499C>T	c.(499-501)CCA>TCA	p.P167S	MYBPC1_uc001tif.1_Missense_Mutation_p.P180S|MYBPC1_uc001tig.2_Missense_Mutation_p.P192S|MYBPC1_uc010svq.1_Missense_Mutation_p.P154S|MYBPC1_uc001tih.2_Missense_Mutation_p.P192S|MYBPC1_uc001tij.2_Missense_Mutation_p.P167S|MYBPC1_uc010svr.1_Missense_Mutation_p.P167S|MYBPC1_uc010svs.1_Missense_Mutation_p.P167S|MYBPC1_uc010svt.1_Missense_Mutation_p.P155S|MYBPC1_uc010svu.1_Missense_Mutation_p.P167S|MYBPC1_uc001tik.2_Missense_Mutation_p.P141S	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	167					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						TGGGACTACTCCAAACATTGA	0.358													4	46					0	0	0	0	T	102028349	T	T	102028349	3	4	165	1	0	0	0	0	1	0	0	0	10064	855	30	2	608	2	MYBPC1	12	102028349	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	58083542	102028349	31823546	62	30283											
ALKBH2	121642	broad.mit.edu	37	chr12	109530419	109530419	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccctcagcccgaatgtgcCgccagctagggcctgctgag	6	6	14	15	2	1	1	1	1	0	0	1	2	1	1	5	2	4	2	5	2	2	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:109530419C>T	uc001tnx.2	-	2	566	c.173G>A	c.(172-174)CGG>CAG	p.R58Q	ALKBH2_uc001tny.2_Missense_Mutation_p.R58Q|ALKBH2_uc010sxj.1_Missense_Mutation_p.R58Q|ALKBH2_uc009zvd.2_Missense_Mutation_p.R58Q|ALKBH2_uc010sxk.1_Missense_Mutation_p.R58Q	NM_001145374	NP_001138846	Q6NS38	ALKB2_HUMAN	AlkB homolog 2	58					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	CCGAATGTGCCGCCAGCTAGG	0.547								Direct_reversal_of_damage					22	132					0	0	0	0	T	109530419	T	T	109530419	3	4	165	1	0	0	0	0	1	0	0	0	527	652	23	1	624	1	ALKBH2	12	109530419	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	7502070	109530419	24321476	63	30284											
RIMBP2	23504	broad.mit.edu	37	chr12	130927037	130927037	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcccgcatctatgtgggttGgggagtggaggtccaggatg	6	10	18	7	1	1	0	0	0	1	0	2	3	2	3	2	6	1	2	2	6	1	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:130927037G>A	uc001uil.2	-	8	973	c.809C>T	c.(808-810)CCA>CTA	p.P270L	RIMBP2_uc001uim.2_Missense_Mutation_p.P178L|RIMBP2_uc001uin.1_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	270						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TATGTGGGTTGGGGAGTGGAG	0.577													15	110					0	0	0	0	A	130927037	A	A	130927037	3	1	165	1	0	0	0	0	1	0	0	0	13428	1348	47	4	2397	4	RIMBP2	12	130927037	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	21396618	130927037	2924858	64	30285											
ZNF10	7556	broad.mit.edu	37	chr12	133732617	133732617	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaaagggcatacatagagAgaaaccctatgaatgtaagg	18	7	10	6	0	1	3	1	1	0	2	1	4	1	3	1	2	2	2	1	2	7	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr12:133732617A>T	uc009zzb.2	+	5	1232	c.785A>T	c.(784-786)GAG>GTG	p.E262V	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.E262V	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	262				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		ATACATAGAGAGAAACCCTAT	0.398													5	49					0	0	0	0	T	133732617	T	T	133732617	3	4	165	1	0	0	0	0	1	0	0	0	17779	304	11	5	799	5	ZNF10	12	133732617	Missense_Mutation	SNP	A	TCGA-CR-7401-01A-11D-2012-08	2805580	133732617	119278	65	30286											
POMP	51371	broad.mit.edu	37	chr13	29252224	29252224	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacttgatggtggaatataaActtggtttactgtaatagtg	12	15	10	4	0	0	1	0	1	0	0	0	2	0	2	0	3	2	2	0	3	7	8			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr13:29252224A>G	uc001usf.2	+	6	492	c.411A>G	c.(409-411)AAA>AAG	p.K137K		NM_015932	NP_057016	Q9Y244	POMP_HUMAN	proteasome maturation protein	137					proteasome assembly	cytosol|endoplasmic reticulum|membrane|microsome|nucleus|proteasome complex					0		Lung SC(185;0.0367)		all cancers(112;0.141)|OV - Ovarian serous cystadenocarcinoma(117;0.216)		TGGAATATAAACTTGGTTTAC	0.343													11	40					0	0	0	0	G	29252224	G	G	29252224	2	3	165	1	0	0	0	0	0	0	0	1	12299	40	2	5		5	POMP	13	29252224	Silent	SNP	A	TCGA-CR-7401-01A-11D-2012-08		29252224	85917654	66	30287											
TRPC4	7223	broad.mit.edu	37	chr13	38211559	38211559	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggcaattgctgctgatctCggatgaatcagggtggttaa	10	11	14	6	1	2	2	1	2	1	0	3	4	2	3	0	4	2	4	0	4	3	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr13:38211559C>T	uc001uws.2	-	11	2650	c.2415G>A	c.(2413-2415)CCG>CCA	p.P805P	TRPC4_uc010abv.2_Silent_p.P385P|TRPC4_uc001uwt.2_Intron|TRPC4_uc010tey.1_Intron|TRPC4_uc010abw.2_Silent_p.P632P|TRPC4_uc010abx.2_Silent_p.P810P|TRPC4_uc010aby.2_Intron	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	805	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CTGCTGATCTCGGATGAATCA	0.443													10	79					0	0	0	0	T	38211559	T	T	38211559	2	4	165	1	0	0	0	0	0	0	0	1	16647	871	31	1		1	TRPC4	13	38211559	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08	8959335	38211559	76958319	67	30288											
RNF31	55072	broad.mit.edu	37	chr14	24629560	24629560	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgagcgctacctgcacgtaCgcccccagcctttggctgga	6	8	11	16	3	0	1	0	1	0	0	0	2	0	2	4	2	5	4	4	2	2	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:24629560C>T	uc001wmn.1	+	20	3358	c.3109C>T	c.(3109-3111)CGC>TGC	p.R1037C	RNF31_uc001wml.1_Missense_Mutation_p.R886C|RNF31_uc010alg.1_Missense_Mutation_p.R796C|RNF31_uc001wmo.1_Missense_Mutation_p.R504C|RNF31_uc001wmp.2_RNA|RNF31_uc010alh.1_Missense_Mutation_p.R221C|IRF9_uc001wmq.2_5'Flank|IRF9_uc010alj.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	1037					CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		CCTGCACGTACGCCCCCAGCC	0.582											OREG0022619	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	111					0	0	0	0	T	24629560	T	T	24629560	3	4	165	1	0	0	0	0	1	0	0	0	13552	536	19	1	3187	1	RNF31	14	24629560	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08		24629560	82719980	68	30289											
MDGA2	161357	broad.mit.edu	37	chr14	47351384	47351384	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcccttttgaatattcccaTttattttaatctcctgctcc	7	19	2	13	0	1	1	0	1	1	0	5	1	4	1	4	0	1	1	4	0	4	8			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:47351384T>C	uc001wwj.3	-	11	2268	c.2072A>G	c.(2071-2073)AAT>AGT	p.N691S	MDGA2_uc001wwh.3_5'UTR|MDGA2_uc001wwi.3_Missense_Mutation_p.N462S|MDGA2_uc010ani.2_Missense_Mutation_p.N251S	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	691					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						AATATTCCCATTTATTTTAAT	0.373													3	23					0	0	0	0	C	47351384	C	C	47351384	3	2	165	1	0	0	0	0	1	0	0	0	9460	1493	52	5	826	5	MDGA2	14	47351384	Missense_Mutation	SNP	T	TCGA-CR-7401-01A-11D-2012-08	22721824	47351384	59998156	69	30290											
NID2	22795	broad.mit.edu	37	chr14	52481904	52481904	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtcatcgcactggggcaCgtactggtcatcccgggggg	6	7	16	12	3	2	0	2	0	0	0	4	0	3	0	1	7	1	3	1	7	1	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:52481904C>T	uc001wzo.2	-	15	3352	c.3118G>A	c.(3118-3120)GTG>ATG	p.V1040M	NID2_uc010tqs.1_Missense_Mutation_p.V992M|NID2_uc010tqt.1_Missense_Mutation_p.V1040M|NID2_uc001wzp.2_Missense_Mutation_p.V1040M	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1040	Thyroglobulin type-1 2.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CACTGGGGCACGTACTGGTCA	0.632													17	81					0	0	0	0	T	52481904	T	T	52481904	3	4	165	1	0	0	0	0	1	0	0	0	10469	536	19	1	1041	1	NID2	14	52481904	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	5130520	52481904	54867636	70	30291											
RPS6KL1	83694	broad.mit.edu	37	chr14	75376271	75376271	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtccaggagcaggttcccGgggtggaggtcccggcacag	6	6	18	11	2	0	0	0	0	0	0	3	2	3	2	3	8	1	3	3	8	0	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:75376271G>A	uc010tux.1	-	7	1773	c.1245C>T	c.(1243-1245)CCC>CCT	p.P415P	RPS6KL1_uc001xqx.1_Silent_p.P167P|RPS6KL1_uc001xqw.2_Silent_p.P384P|RPS6KL1_uc010asd.1_RNA	NM_031464	NP_113652	Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	415	Protein kinase.					ribosome	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00658)		GCAGGTTCCCGGGGTGGAGGT	0.672													12	45					0	0	0	0	A	75376271	A	A	75376271	2	1	165	1	0	0	0	0	0	0	0	1	13724	1103	39	1		1	RPS6KL1	14	75376271	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	22894367	75376271	31973269	71	30292											
KIAA1409	57578	broad.mit.edu	37	chr14	94120290	94120290	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atcgttgactttccagatggGacttttttacggaccttagc	8	15	9	9	2	0	2	0	1	0	1	2	4	1	4	2	2	2	1	2	2	2	6			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr14:94120290G>C	uc001ybv.1	+	36	5936	c.5853G>C	c.(5851-5853)GGG>GGC	p.G1951G	KIAA1409_uc001ybs.1_Silent_p.G1929G	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2106						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TTCCAGATGGGACTTTTTTAC	0.483													5	162					0	0	0	0	C	94120290	C	C	94120290	2	2	165	1	0	0	0	0	0	0	0	1	8269	1161	41	2		2	KIAA1409	14	94120290	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	18744019	94120290	13229250	72	30293											
ADAMTS7	11173	broad.mit.edu	37	chr15	79054873	79054873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgacacacttgaccaggCgccgctggacaccaccacca	10	6	9	16	2	0	2	0	2	0	0	0	3	0	3	5	2	0	2	5	2	0	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr15:79054873C>T	uc002bej.3	-	23	4986	c.4775G>A	c.(4774-4776)CGC>CAC	p.R1592H		NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1592	TSP type-1 8.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CTTGACCAGGCGCCGCTGGAC	0.677													3	12					0	0	0	0	T	79054873	T	T	79054873	3	4	165	1	0	0	0	0	1	0	0	0	271	768	27	1	293	1	ADAMTS7	15	79054873	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08		79054873	23476519	73	30294											
PEX11A	8800	broad.mit.edu	37	chr15	90226612	90226612	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caagcctaaaaacaccctaaCgggtcttcagcttcatctga	13	9	6	13	1	4	1	2	1	2	0	4	1	4	1	2	1	4	1	2	1	5	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr15:90226612C>T	uc002boi.2	-	3	835	c.740G>A	c.(739-741)CGT>CAT	p.R247H	PEX11A_uc010upy.1_RNA	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	247	Cytoplasmic (Potential).				cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			AACACCCTAACGGGTCTTCAG	0.443													62	207					0	0	0	0	T	90226612	T	T	90226612	3	4	165	1	0	0	0	0	1	0	0	0	11792	536	19	1	7	1	PEX11A	15	90226612	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	11171739	90226612	12304780	74	30295											
MVP	9961	broad.mit.edu	37	chr16	29848052	29848052	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgctctgcagacagccctgCacctccgggctcggcggaac	6	7	12	16	3	1	1	0	0	1	1	3	2	2	2	3	3	5	4	3	3	1	1	rs150165807		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:29848052C>T	uc002dui.2	+	7	766	c.682C>T	c.(682-684)CAC>TAC	p.H228Y	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010bzh.1_RNA|MVP_uc010vdz.1_RNA|MVP_uc002duj.2_Missense_Mutation_p.H228Y|MVP_uc010vea.1_5'UTR	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	228	MVP 5.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GACAGCCCTGCACCTCCGGGC	0.622													4	46					0	0	0	0	T	29848052	T	T	29848052	3	4	165	1	0	0	0	0	1	0	0	0	10049	710	25	4	704	4	MVP	16	29848052	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08		29848052	60506701	75	30296											
SRCAP	10847	broad.mit.edu	37	chr16	30750152	30750152	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcacagacccaatcccctcCtgtcacctgtggagaaaaga	12	8	7	14	0	2	3	2	0	0	3	4	4	4	3	5	1	0	0	5	1	3	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:30750152C>T	uc002dze.1	+	34	9176	c.8791C>T	c.(8791-8793)CTG>TTG	p.L2931L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.L2726L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2931	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CAATCCCCTCCTGTCACCTGT	0.572													12	79					0	0	0	0	T	30750152	T	T	30750152	2	4	165	1	0	0	0	0	0	0	0	1	15201	680	24	4		4	SRCAP	16	30750152	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08	902100	30750152	59604601	76	30297											
ATP6V0D1	9114	broad.mit.edu	37	chr16	67472541	67472543	+	In_Frame_Del	DEL	AGA	-	-																															cttgagcttcacgaaggcatAgaagacaccaaagtggaact																										TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:67472541_67472543delAGA	uc002ete.1	-	8	1044_1046	c.944_946delTCT	c.(943-948)TTCTAT>TAT	p.F315del	ATP6V0D1_uc010vjo.1_In_Frame_Del_p.F356del|ATP6V0D1_uc010vjn.1_In_Frame_Del_p.F238del	NM_004691	NP_004682	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	315					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		ACGAAGGCATAGAAGACACCAAA	0.552													---	---	---								-	67472543	-	-	67472541	7	5	165	1	0	1	0	1	0	0	0	0	1175	420	15	0	113	0	ATP6V0D1	16	67472541	In_Frame_Del	DEL	AGA	TCGA-CR-7401-01A-11D-2012-08	36722389	67472541	22882212	77	30298											
ACD	65057	broad.mit.edu	37	chr16	67693460	67693460	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caaccaggcacccgtagccgGggctgctccgtgggcagcag	7	4	15	15	3	0	0	0	0	0	0	1	0	1	0	4	4	4	6	4	4	2	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr16:67693460G>A	uc002etq.3	-	4	988	c.651C>T	c.(649-651)CCC>CCT	p.P217P	ACD_uc002etp.3_Silent_p.P214P|ACD_uc002etr.3_Silent_p.P214P|ACD_uc010vjt.1_Missense_Mutation_p.P237S|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	217					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCCGTAGCCGGGGCTGCTCCG	0.677													4	48					0	0	0	0	A	67693460	A	A	67693460	2	1	165	1	0	0	0	0	0	0	0	1	135	1219	43	4		4	ACD	16	67693460	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	220919	67693460	22661293	78	30299											
NLRP1	22861	broad.mit.edu	37	chr17	5486116	5486116	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggtggaggtgggttggctggGagaccccaggtggggttcac	5	8	21	7	0	1	1	1	0	0	1	1	3	1	2	2	9	0	3	2	9	0	2	rs141118572		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:5486116G>C	uc002gci.2	-	2	877	c.322C>G	c.(322-324)CCC>GCC	p.P108A	NLRP1_uc002gcg.1_Missense_Mutation_p.P108A|NLRP1_uc002gck.2_Missense_Mutation_p.P108A|NLRP1_uc002gcj.2_Missense_Mutation_p.P108A|NLRP1_uc002gcl.2_Missense_Mutation_p.P108A|NLRP1_uc002gch.3_Missense_Mutation_p.P108A|NLRP1_uc010clh.2_Missense_Mutation_p.P108A	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	108					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GGTTGGCTGGGAGACCCCAGG	0.602													9	37					0	0	0	0	C	5486116	C	C	5486116	3	2	165	1	0	0	0	0	1	0	0	0	10525	1174	41	2	4238	2	NLRP1	17	5486116	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08		5486116	75709094	79	30300											
TP53	7157	broad.mit.edu	37	chr17	7578177	7578177	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accccagttgcaaaccagacCtcaggcggctcatagggcac	11	5	10	15	1	2	1	2	0	0	1	2	1	2	1	4	3	2	4	4	3	2	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:7578177C>T	uc002gim.2	-	6	866	c.672G>A	c.(670-672)GAG>GAA	p.E224E	TP53_uc002gig.1_Silent_p.E224E|TP53_uc002gih.2_Silent_p.E224E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Silent_p.E92E|TP53_uc010cng.1_Silent_p.E92E|TP53_uc002gii.1_Silent_p.E92E|TP53_uc010cnh.1_Silent_p.E224E|TP53_uc010cni.1_Silent_p.E224E|TP53_uc002gij.2_Silent_p.E224E|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Silent_p.E131E|TP53_uc002gio.2_Silent_p.E92E|TP53_uc010vug.1_Silent_p.E185E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	224	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E224D(11)|p.0?(7)|p.E224E(6)|p.E224K(5)|p.E224*(4)|p.?(3)|p.E224G(2)|p.E224fs*4(1)|p.E224fs*5(1)|p.V218_E224delVPYEPPE(1)|p.E224fs*23(1)|p.V225fs*24(1)|p.E224fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAACCAGACCTCAGGCGGCT	0.522		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	24					0	0	0	0	T	7578177	T	T	7578177	2	4	165	1	0	0	0	0	0	0	0	1	16448	695	24	4		4	TP53	17	7578177	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08	2092061	7578177	73617033	80	30301											
CNTROB	116840	broad.mit.edu	37	chr17	7842957	7842957	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcgagagttggagactcttCgggctgccctagaagaagaa	12	8	13	8	2	1	5	0	0	1	5	3	7	1	5	1	2	1	2	1	2	4	3	rs141146363		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:7842957C>T	uc002gjq.2	+	9	1973	c.1054C>T	c.(1054-1056)CGG>TGG	p.R352W	CNTROB_uc002gjp.2_Missense_Mutation_p.R352W|CNTROB_uc002gjr.2_Missense_Mutation_p.R254W|CNTROB_uc010vum.1_Missense_Mutation_p.R64W	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	352	Potential.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				GGAGACTCTTCGGGCTGCCCT	0.612													18	62					0	0	0	0	T	7842957	T	T	7842957	3	4	165	1	0	0	0	0	1	0	0	0	3666	875	31	1	1084	1	CNTROB	17	7842957	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	264780	7842957	73352253	81	30302											
ACACA	31	broad.mit.edu	37	chr17	35591984	35591984	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtcacttttattctcttctCggagggcgaatacacatttg	8	16	8	9	2	3	0	1	0	2	0	5	2	3	1	0	2	1	0	0	2	3	6			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:35591984C>T	uc002hnm.2	-	25	3232	c.3041G>A	c.(3040-3042)CGA>CAA	p.R1014Q	ACACA_uc002hnk.2_Missense_Mutation_p.R936Q|ACACA_uc002hnl.2_Missense_Mutation_p.R956Q|ACACA_uc002hnn.2_Missense_Mutation_p.R1014Q|ACACA_uc002hno.2_Missense_Mutation_p.R1051Q|ACACA_uc010cuz.2_Missense_Mutation_p.R1014Q	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1014					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ATTCTCTTCTCGGAGGGCGAA	0.393													11	49					0	0	0	0	T	35591984	T	T	35591984	3	4	165	1	0	0	0	0	1	0	0	0	106	884	31	1	4127	1	ACACA	17	35591984	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	27749027	35591984	45603226	82	30303											
KRT38	8687	broad.mit.edu	37	chr17	39594347	39594347	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcccagatcacacgtacttGcagtcctcgctttccagaag	9	10	8	14	2	1	2	1	0	0	2	4	2	3	2	3	0	3	3	3	0	2	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:39594347G>T	uc002hwq.1	-	6	1662	c.1239C>A	c.(1237-1239)TGC>TGA	p.C413*		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	413	Tail.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				ACACGTACTTGCAGTCCTCGC	0.527													8	54					0.000157383	0.000168536	1	0	T	39594347	T	T	39594347	4	4	165	1	0	0	0	0	0	1	0	0	8514	1311	46	4	139	4	KRT38	17	39594347	Nonsense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	4002363	39594347	41600863	83	30304											
NAGS	162417	broad.mit.edu	37	chr17	42083545	42083545	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtcgctggccaaggcgctGcggcccaccaaaatcatctt	8	7	11	15	4	2	0	1	0	1	0	3	0	2	0	3	3	1	2	3	3	3	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:42083545G>A	uc002ies.2	+	3	855	c.855G>A	c.(853-855)CTG>CTA	p.L285L	PYY_uc002ieq.2_5'Flank|NAGS_uc010czn.2_Silent_p.L285L|NAGS_uc002iet.2_5'UTR	NM_153006	NP_694551	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	285					arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity				0		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	CCAAGGCGCTGCGGCCCACCA	0.667													11	38					0	0	0	0	A	42083545	A	A	42083545	2	1	165	1	0	0	0	0	0	0	0	1	10198	1306	46	4		4	NAGS	17	42083545	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	2489198	42083545	39111665	84	30305											
METTL2A	339175	broad.mit.edu	37	chr17	60501347	60501347	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccggttcctgagagatccGgcgcgcgtcttccaccacaa	8	7	11	15	5	1	2	0	1	1	1	4	3	4	2	5	2	1	1	5	2	1	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr17:60501347G>T	uc002izv.2	+	1	102	c.84G>T	c.(82-84)CCG>CCT	p.P28P	METTL2A_uc002izw.2_5'UTR	NM_181725	NP_859076	Q96IZ6	MTL2A_HUMAN	methyltransferase like 2A	28							methyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(2;1.08e-10)			TGAGAGATCCGGCGCGCGTCT	0.647											OREG0024635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	45					0.000157383	0.000168536	1	0	T	60501347	T	T	60501347	2	4	165	1	0	0	0	0	0	0	0	1	9552	1103	39	3		3	METTL2A	17	60501347	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	18417802	60501347	20693863	85	30306											
LAMA3	3909	broad.mit.edu	37	chr18	21330961	21330961	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgagggagtttaccaaggCaacaaacatccgcttgcgtt	11	9	10	11	2	0	1	0	1	0	0	1	2	1	2	3	2	4	4	3	2	4	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr18:21330961C>T	uc002kuq.2	+	5	850	c.764C>T	c.(763-765)GCA>GTA	p.A255V	LAMA3_uc010dlv.1_Missense_Mutation_p.A255V|LAMA3_uc002kur.2_Missense_Mutation_p.A255V	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	255	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTACCAAGGCAACAAACATC	0.473													33	85					0	0	0	0	T	21330961	T	T	21330961	3	4	165	1	0	0	0	0	1	0	0	0	8647	710	25	4	782	4	LAMA3	18	21330961	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08		21330961	56746287	86	30307											
ASXL3	80816	broad.mit.edu	37	chr18	31319491	31319491	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atctgaagcatcaccagtatCcaacttacctttaacatcag	14	11	4	12	0	3	1	2	1	1	0	4	1	4	1	3	0	4	2	3	0	5	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr18:31319491C>G	uc010dmg.1	+	11	2178	c.2123C>G	c.(2122-2124)TCC>TGC	p.S708C	ASXL3_uc002kxq.2_Missense_Mutation_p.S415C	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	708	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TCACCAGTATCCAACTTACCT	0.393													37	204					0	0	0	0	G	31319491	G	G	31319491	3	3	165	1	0	0	0	0	1	0	0	0	1070	855	30	2	2165	2	ASXL3	18	31319491	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	9988530	31319491	46757757	87	30308											
WDR7	23335	broad.mit.edu	37	chr18	54591315	54591315	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggggcttctcgaactttgtgCcgatgccgagaaacaacttg	9	10	12	10	3	1	1	0	0	1	1	2	4	1	1	2	2	5	1	2	2	3	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr18:54591315C>T	uc002lgk.1	+	22	3900	c.3689C>T	c.(3688-3690)GCC>GTC	p.A1230V	WDR7_uc002lgl.1_Missense_Mutation_p.A1197V	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1230										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GAACTTTGTGCCGATGCCGAG	0.438													4	135					0	0	0	0	T	54591315	T	T	54591315	3	4	165	1	0	0	0	0	1	0	0	0	17388	739	26	4	3771	4	WDR7	18	54591315	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	23271824	54591315	23485933	88	30309											
MUC16	94025	broad.mit.edu	37	chr19	9066782	9066782	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtggtttccacattagtCgctgctgtgcttgtggaagg	5	14	14	8	1	0	0	0	0	0	0	2	1	1	1	1	4	2	4	1	4	2	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:9066782C>A	uc002mkp.2	-	3	20868	c.20664G>T	c.(20662-20664)GCG>GCT	p.A6888A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6890	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCACATTAGTCGCTGCTGTGC	0.483													37	177					6.53348e-20	7.46683e-20	1	0	A	9066782	A	A	9066782	2	1	165	1	0	0	0	0	0	0	0	1	10026	871	31	3		3	MUC16	19	9066782	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08		9066782	50062201	89	30310											
TSHZ3	57616	broad.mit.edu	37	chr19	31769049	31769049	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggaagttggtaggcggcatgGatgctgggatagccccccca	8	7	16	10	1	0	0	0	0	0	0	0	3	0	3	3	6	2	4	3	6	3	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:31769049G>A	uc002nsy.3	-	2	1715	c.1650C>T	c.(1648-1650)ATC>ATT	p.I550I		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	550					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					AGGCGGCATGGATGCTGGGAT	0.552													12	130					0	0	0	0	A	31769049	A	A	31769049	2	1	165	1	0	0	0	0	0	0	0	1	16692	1164	41	2		2	TSHZ3	19	31769049	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	22702267	31769049	27359934	90	30311											
TMEM145	284339	broad.mit.edu	37	chr19	42818774	42818774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccttccccaggactgcctgGccaaggagtcagtgatccgg	7	7	13	14	1	1	1	1	1	0	0	3	3	3	3	6	4	1	0	6	4	1	1			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:42818774G>A	uc002otk.1	+	4	335	c.283G>A	c.(283-285)GCC>ACC	p.A95T		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	95						integral to membrane					0		Prostate(69;0.00682)				GGACTGCCTGGCCAAGGAGTC	0.642													14	131					0	0	0	0	A	42818774	A	A	42818774	3	1	165	1	0	0	0	0	1	0	0	0	16125	1203	42	4	297	4	TMEM145	19	42818774	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	11049725	42818774	16310209	91	30312											
C5AR1	728	broad.mit.edu	37	chr19	47823557	47823557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccataccctccttcctgtacCgggtggtccgggaggagtac	6	9	12	14	2	0	0	0	0	0	0	3	2	3	2	6	4	3	2	6	4	3	4	rs141160351		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:47823557C>T	uc002pgj.1	+	2	572	c.523C>T	c.(523-525)CGG>TGG	p.R175W		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	175	Extracellular (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CTTCCTGTACCGGGTGGTCCG	0.632													29	133					0	0	0	0	T	47823557	T	T	47823557	3	4	165	1	0	0	0	0	1	0	0	0	2291	643	23	1	528	1	C5AR1	19	47823557	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	5004783	47823557	11305426	92	30313											
ZNF649	65251	broad.mit.edu	37	chr19	52394087	52394087	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaagtaagctttctcacaCtcatcacagccatagggtct	12	11	7	11	0	4	1	3	0	2	1	5	1	4	1	1	1	2	2	1	1	4	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:52394087C>A	uc002pxy.2	-	5	1570	c.1302G>T	c.(1300-1302)GAG>GAT	p.E434D	ZNF577_uc010ydd.1_5'Flank|ZNF577_uc002pxx.3_5'Flank|ZNF577_uc002pxv.2_5'Flank|ZNF577_uc002pxw.2_5'Flank|ZNF577_uc010yde.1_5'Flank|ZNF577_uc010ydf.1_RNA	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	434	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTTTCTCACACTCATCACAGC	0.438													27	145					3.01185e-09	3.35747e-09	1	0	A	52394087	A	A	52394087	3	1	165	1	0	0	0	0	1	0	0	0	18131	564	20	4	219	4	ZNF649	19	52394087	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	4570530	52394087	6734896	93	30314											
ZNF761	388561	broad.mit.edu	37	chr19	53958193	53958193	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcagcttggatcaagcttTcattcgcatctgcctgaaat	10	13	8	10	1	4	1	3	1	1	0	5	3	4	2	1	1	3	3	1	1	2	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:53958193T>C	uc010eqp.2	+	7	890	c.432T>C	c.(430-432)TTT>TTC	p.F144F	ZNF761_uc010ydy.1_Silent_p.F90F|ZNF761_uc002qbt.1_Silent_p.F90F	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		GATCAAGCTTTCATTCGCATC	0.393													17	108					0	0	0	0	C	53958193	C	C	53958193	2	2	165	1	0	0	0	0	0	0	0	1	18203	1780	62	5		5	ZNF761	19	53958193	Silent	SNP	T	TCGA-CR-7401-01A-11D-2012-08	1564106	53958193	5170790	94	30315											
KIR3DL1	3811	broad.mit.edu	37	chr19	55378185	55378185	+	Nonstop_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggtcttgagggggttttctAgggagacaacagccctgtct	8	11	14	8	0	3	2	0	1	3	1	3	3	3	2	1	4	2	1	1	4	2	4			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:55378185A>G	uc002qhl.3	+	9	1430	c.1367A>G	c.(1366-1368)TAG>TGG	p.*456W	KIR3DL2_uc010esh.2_Nonstop_Mutation_p.*439W|KIR3DL2_uc002qho.3_Nonstop_Mutation_p.*456W			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	456					immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GGGGTTTTCTAGGGAGACAAC	0.527													3	180					0	0	0	0	G	55378185	G	G	55378185	4	3	165	1	0	0	0	0	0	0	0	0	8359	433	15	5		5	KIR3DL1	19	55378185	Nonstop_Mutation	SNP	A	TCGA-CR-7401-01A-11D-2012-08	1419992	55378185	3750798	95	30316											
ZNF471	57573	broad.mit.edu	37	chr19	57037304	57037304	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcatcaaagaagtcatactgGagaagaaccttaagaatgta	18	9	8	6	0	3	4	3	0	0	4	3	5	3	4	1	1	2	1	1	1	8	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:57037304G>C	uc002qnh.2	+	5	2001	c.1868G>C	c.(1867-1869)GGA>GCA	p.G623A		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	623					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		AGTCATACTGGAGAAGAACCT	0.403													9	45					0	0	0	0	C	57037304	C	C	57037304	3	2	165	1	0	0	0	0	1	0	0	0	17997	1174	41	2	1882	2	ZNF471	19	57037304	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	1659119	57037304	2091679	96	30317											
ZNF548	147694	broad.mit.edu	37	chr19	57911175	57911175	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgaagagaggcttgtgtgctCcatgaatgtggggaattctt	9	13	14	5	0	1	3	0	2	1	1	2	5	2	4	1	3	1	2	1	3	3	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr19:57911175C>G	uc002qom.2	+	3	1770	c.1520C>G	c.(1519-1521)TCC>TGC	p.S507C	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.S510C	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTTGTGTGCTCCATGAATGTG	0.358													9	44					0	0	0	0	G	57911175	G	G	57911175	3	3	165	1	0	0	0	0	1	0	0	0	18047	855	30	2	1570	2	ZNF548	19	57911175	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	873871	57911175	1217808	97	30318											
PREX1	57580	broad.mit.edu	37	chr20	47296246	47296246	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taggtgccatcgtcgtagcgGaagcgatacatcacctgctc	9	9	11	12	4	1	0	1	0	0	0	4	2	1	1	2	2	5	2	2	2	4	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr20:47296246G>A	uc002xtw.1	-	12	1505	c.1482C>T	c.(1480-1482)TTC>TTT	p.F494F		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	494	DEP 1.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CGTCGTAGCGGAAGCGATACA	0.612													16	95					0	0	0	0	A	47296246	A	A	47296246	2	1	165	1	0	0	0	0	0	0	0	1	12538	1165	41	2		2	PREX1	20	47296246	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08		47296246	15729274	98	30319											
PTGIS	5740	broad.mit.edu	37	chr20	48130868	48130868	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagctctccgcggacagcaGccagggcttcaggattcttg	7	8	13	13	3	3	0	1	0	2	0	4	3	3	2	2	3	3	3	2	3	0	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr20:48130868G>A	uc002xut.2	-	7	974	c.920C>T	c.(919-921)GCT>GTT	p.A307V	PTGIS_uc010zyi.1_Missense_Mutation_p.A168V	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	307					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity	p.A307S(1)		skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	GCGGACAGCAGCCAGGGCTTC	0.577													8	57					0	0	0	0	A	48130868	A	A	48130868	3	1	165	1	0	0	0	0	1	0	0	0	12815	971	34	4	598	4	PTGIS	20	48130868	Missense_Mutation	SNP	G	TCGA-CR-7401-01A-11D-2012-08	834622	48130868	14894652	99	30320											
PRDM15	63977	broad.mit.edu	37	chr21	43287419	43287419	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagccctgacctcctccgttCgcaatcttccccagggctgg	5	10	9	17	2	1	1	0	1	1	0	5	1	4	1	6	2	1	3	6	2	2	3	rs137957423		TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr21:43287419C>T	uc002yzq.1	-	5	720	c.609G>A	c.(607-609)GCG>GCA	p.A203A	PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTCCTCCGTTCGCAATCTTCC	0.532													20	119					0	0	0	0	T	43287419	T	T	43287419	2	4	165	1	0	0	0	0	0	0	0	1	12518	871	31	1		1	PRDM15	21	43287419	Silent	SNP	C	TCGA-CR-7401-01A-11D-2012-08		43287419	4842476	100	30321											
PLA2G3	50487	broad.mit.edu	37	chr22	31535944	31535944	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gactccactctgccctgctgCtcgcttcttcctggcccctg	2	12	8	19	1	2	0	0	0	2	0	5	1	4	0	5	1	3	3	5	1	0	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:31535944C>T	uc003aka.2	-	1	526	c.397G>A	c.(397-399)GCA>ACA	p.A133T		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	133					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						TGCCCTGCTGCTCGCTTCTTC	0.632													6	77					0	0	0	0	T	31535944	T	T	31535944	3	4	165	1	0	0	0	0	1	0	0	0	12055	797	28	4	1160	4	PLA2G3	22	31535944	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08		31535944	19768622	101	30322											
C1QTNF6	114904	broad.mit.edu	37	chr22	37584356	37584357	+	5'Flank	INS	-	A	A																															aggggatggagggagagaggINSgcggagggagggcggaggga																										TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:37584356_37584357insA	uc003aqw.1	-						C1QTNF6_uc003aqx.1_5'Flank|C1QTNF6_uc003aqy.1_5'Flank|C1QTNF6_uc003aqz.1_RNA	NM_182486	NP_872292	Q9BXI9	C1QT6_HUMAN	C1q and tumor necrosis factor related protein 6							collagen					0						agggagagagggcggagggagg	0.455													---	---	---								A	37584357	A	A	37584356	6	5	165	0	1	1	1	0	0	0	0	0	1976	1247	43	0		0	C1QTNF6	22	37584356	5'Flank	INS	-	TCGA-CR-7401-01A-11D-2012-08	6048412	37584356	13720210	102	30323											
MKL1	57591	broad.mit.edu	37	chr22	40825661	40825661	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggaaggatgttcttctccaCcagctccatggggccaggcc	8	8	12	13	0	2	0	0	0	2	0	4	2	3	2	5	5	1	2	5	5	1	2			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:40825661C>T	uc003ayv.1	-	4	457	c.250G>A	c.(250-252)GTG>ATG	p.V84M	MKL1_uc003ayw.1_Missense_Mutation_p.V84M|MKL1_uc010gye.1_Missense_Mutation_p.V84M|MKL1_uc010gyf.1_Missense_Mutation_p.V84M	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	84	RPEL 2.|Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TTCTTCTCCACCAGCTCCATG	0.572			T	RBM15	acute megakaryocytic leukemia								6	68					0	0	0	0	T	40825661	T	T	40825661	3	4	165	1	0	0	0	0	1	0	0	0	9654	507	18	4	2581	4	MKL1	22	40825661	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	3241305	40825661	10478905	103	30324											
SMC1B	27127	broad.mit.edu	37	chr22	45782901	45782901	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttacagcctttaagctccCttagtctttcattgattggc	7	18	6	10	0	2	1	1	1	1	0	3	1	3	1	2	1	3	1	2	1	3	8			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chr22:45782901C>T	uc003bgc.2	-	11	1809	c.1757G>A	c.(1756-1758)AGG>AAG	p.R586K	SMC1B_uc003bgd.2_Missense_Mutation_p.R586K|SMC1B_uc003bge.1_Missense_Mutation_p.R369K	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	586	Flexible hinge.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TTTAAGCTCCCTTAGTCTTTC	0.328													34	93					0	0	0	0	T	45782901	T	T	45782901	3	4	165	1	0	0	0	0	1	0	0	0	14846	681	24	4	2010	4	SMC1B	22	45782901	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	4957240	45782901	5521665	104	30325											
KLHL15	80311	broad.mit.edu	37	chrX	24024381	24024381	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gactccctcgatgtttacgcCgaaatcatctaagagtctca	11	11	7	12	3	3	1	2	0	2	1	6	4	4	1	2	0	1	1	2	0	3	3			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chrX:24024381C>T	uc004dba.3	-	3	686	c.430G>A	c.(430-432)GGC>AGC	p.G144S		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	144	BACK.									ovary(1)|breast(1)	2						ATGTTTACGCCGAAATCATCT	0.428													13	18					0	0	0	0	T	24024381	T	T	24024381	3	4	165	1	0	0	0	0	1	0	0	0	8410	652	23	1	1392	1	KLHL15	23	24024381	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08		24024381	131246179	105	30326											
MAGED1	9500	broad.mit.edu	37	chrX	51640125	51640125	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaactcgcgtgcctcacaGaacccaggtgctgcacagcc	9	5	9	18	2	1	1	1	0	0	1	2	1	1	1	4	1	6	2	4	1	2	0			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chrX:51640125G>A	uc004dpm.2	+	4	1469	c.1374G>A	c.(1372-1374)CAG>CAA	p.Q458Q	MAGED1_uc004dpn.2_Silent_p.Q514Q|MAGED1_uc004dpo.2_Silent_p.Q458Q	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	458					apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					GTGCCTCACAGAACCCAGGTG	0.577										Multiple Myeloma(10;0.10)			4	19					0	0	0	0	A	51640125	A	A	51640125	2	1	165	1	0	0	0	0	0	0	0	1	9236	933	33	2		2	MAGED1	23	51640125	Silent	SNP	G	TCGA-CR-7401-01A-11D-2012-08	27615744	51640125	103630435	106	30327											
MTMR8	55613	broad.mit.edu	37	chrX	63579362	63579362	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagataaagaatcccattagCtggtttcttactcacataac	15	12	5	9	0	2	2	1	0	1	2	3	2	3	2	1	1	3	2	1	1	7	5			TCGA-CR-7401-01A-11D-2012-08	TCGA-CR-7401-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8d6968c-2648-4dcf-a0da-77e46878581c	53ddf2bb-b744-450f-8c57-0ec68c17fc4e	g.chrX:63579362C>T	uc004dvs.2	-	2	138	c.70G>A	c.(70-72)GCT>ACT	p.A24T	MTMR8_uc011mou.1_Missense_Mutation_p.A24T|MTMR8_uc004dvt.1_Missense_Mutation_p.A24T	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	24						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						ATCCCATTAGCTGGTTTCTTA	0.408													14	18					0	0	0	0	T	63579362	T	T	63579362	3	4	165	1	0	0	0	0	1	0	0	0	10002	797	28	4	2096	4	MTMR8	23	63579362	Missense_Mutation	SNP	C	TCGA-CR-7401-01A-11D-2012-08	11939237	63579362	91691198	107	30328											
PRDM16	63976	broad.mit.edu	37	chr1	3319429	3319429	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctgcggcgccataagaagTacacgtgtggctcagtgggg	9	7	15	10	3	1	1	1	0	0	1	1	1	1	1	2	4	2	2	2	4	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:3319429T>G	uc001akf.2	+	6	831	c.751T>G	c.(751-753)TAC>GAC	p.Y251D	PRDM16_uc001akc.2_Missense_Mutation_p.Y251D|PRDM16_uc001akd.2_Missense_Mutation_p.Y251D|PRDM16_uc001ake.2_Missense_Mutation_p.Y251D|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	251	C2H2-type 1; atypical.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CCATAAGAAGTACACGTGTGG	0.637			T	EVI1	MDS|AML								49	33					0	0	0	0	G	3319429	G	G	3319429	3	3	166	1	0	0	0	0	1	0	0	0	12519	1638	57	5	773	5	PRDM16	1	3319429	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08		3319429	245931192	1	30329											
CCDC27	148870	broad.mit.edu	37	chr1	3679735	3679735	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acctgggaggtggcgaggagGacgagggcctggaaggggag	9	3	23	6	2	0	0	0	0	0	0	0	7	0	5	2	9	0	0	2	9	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:3679735G>T	uc001akv.2	+	7	1099	c.1018G>T	c.(1018-1020)GAC>TAC	p.D340Y		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	340	Glu-rich.									skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TGGCGAGGAGGACGAGGGCCT	0.617													3	0					0.004672	0.00754293	1	0	T	3679735	T	T	3679735	3	4	166	1	0	0	0	0	1	0	0	0	2814	1174	41	2	1044	2	CCDC27	1	3679735	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	360306	3679735	245570886	2	30330											
KIAA0562	9731	broad.mit.edu	37	chr1	3754057	3754057	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccagaacgagcgaggggctgGaggggcaaatcaaaaggtct	13	4	16	8	2	2	1	1	0	1	1	2	4	2	2	1	6	2	2	1	6	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:3754057G>C	uc001aky.2	-	9	1277	c.918C>G	c.(916-918)CTC>CTG	p.L306L	KIAA0562_uc010nzm.1_RNA|KIAA0562_uc001akz.2_Silent_p.L306L	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	306						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		CGAGGGGCTGGAGGGGCAAAT	0.458													22	27					0	0	0	0	C	3754057	C	C	3754057	2	2	166	1	0	0	0	0	0	0	0	1	8223	1161	41	2		2	KIAA0562	1	3754057	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	74322	3754057	245496564	3	30331											
MASP2	10747	broad.mit.edu	37	chr1	11090242	11090242	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatccattaccaggctcacAgactgggagtgatttttctc	9	13	9	10	0	2	2	1	1	1	1	4	3	3	3	2	2	1	2	2	2	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:11090242A>T	uc001aru.2	-	10	1309	c.1288T>A	c.(1288-1290)TGT>AGT	p.C430S		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	430	Sushi 2.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		CCAGGCTCACAGACTGGGAGT	0.438													45	33					0	0	0	0	T	11090242	T	T	11090242	3	4	166	1	0	0	0	0	1	0	0	0	9376	188	7	5	780	5	MASP2	1	11090242	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	7336185	11090242	238160379	4	30332											
LOC649330	649330	broad.mit.edu	37	chr1	12908094	12908094	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagattcccaatgaacacacGggagttcatggagtgaggat	13	8	13	7	1	1	3	1	2	0	1	2	7	2	6	1	3	1	1	1	3	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:12908094G>C	uc009vno.2	-	1	144	c.49C>G	c.(49-51)CGT>GGT	p.R17G	HNRNPCL1_uc010obf.1_Missense_Mutation_p.R17G	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	17							nucleic acid binding|nucleotide binding				0						ATGAACACACGGGAGTTCATG	0.463													33	111					0	0	0	0	C	12908094	C	C	12908094	3	2	166	1	0	0	0	0	1	0	0	0	8935	1116	39	3	836	3	LOC649330	1	12908094	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1817852	12908094	236342527	5	30333											
TAS1R2	80834	broad.mit.edu	37	chr1	19168324	19168324	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgccctgactggcacctcTtggaacacatggacataggg	9	10	11	11	0	1	1	0	1	1	0	1	3	1	3	2	4	2	1	2	4	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:19168324T>A	uc001bba.1	-	5	1491	c.1490A>T	c.(1489-1491)AAG>ATG	p.K497M		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	497	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CTGGCACCTCTTGGAACACAT	0.587													25	75					0	0	0	0	A	19168324	A	A	19168324	3	1	166	1	0	0	0	0	1	0	0	0	15629	1609	56	5	1037	5	TAS1R2	1	19168324	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	6260230	19168324	230082297	6	30334											
UBR4	23352	broad.mit.edu	37	chr1	19428082	19428082	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtagtcatccagattgtagcGcttggctgtctcaatgcaca	9	12	10	10	1	2	1	2	0	1	1	4	1	3	1	1	1	2	5	1	1	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:19428082G>T	uc001bbi.2	-	88	12959	c.12955C>A	c.(12955-12957)CGC>AGC	p.R4319S	UBR4_uc010ocv.1_5'Flank|UBR4_uc009vph.2_5'Flank|UBR4_uc010ocw.1_Missense_Mutation_p.R10S|UBR4_uc001bbg.2_Missense_Mutation_p.R30S|UBR4_uc001bbh.2_Missense_Mutation_p.R28S	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	4319					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGATTGTAGCGCTTGGCTGTC	0.527													37	79					2.87052e-16	6.34297e-16	1	0	T	19428082	T	T	19428082	3	4	166	1	0	0	0	0	1	0	0	0	16972	1087	38	3	2672	3	UBR4	1	19428082	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	259758	19428082	229822539	7	30335											
PINK1	65018	broad.mit.edu	37	chr1	20977105	20977105	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggaaacaaaaatgaagaTgctctttctggctaacctgg	13	11	10	7	0	2	2	0	1	2	1	2	3	2	3	1	3	3	2	1	3	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:20977105T>A	uc001bdm.2	+	8	1761	c.1667T>A	c.(1666-1668)ATG>AAG	p.M556K	PINK1_uc001bdn.2_Missense_Mutation_p.M249K	NM_032409	NP_115785	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1 precursor	556	Cytoplasmic (Potential).				cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			ovary(2)|central_nervous_system(1)	3		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AAAATGAAGATGCTCTTTCTG	0.542													32	23					0	0	0	0	A	20977105	A	A	20977105	3	1	166	1	0	0	0	0	1	0	0	0	11987	1464	51	5	1697	5	PINK1	1	20977105	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1549023	20977105	228273516	8	30336											
EPHA8	2046	broad.mit.edu	37	chr1	22919856	22919856	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgatccgtcaagagcgggcGgggcagaccagcgtctcgct	7	6	16	12	5	2	3	1	1	1	2	4	3	3	3	2	3	2	2	2	3	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:22919856G>A	uc001bfx.1	+	6	1478	c.1353G>A	c.(1351-1353)GCG>GCA	p.A451A		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	451	Extracellular (Potential).|Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AAGAGCGGGCGGGGCAGACCA	0.657													3	3					0	0	0	0	A	22919856	A	A	22919856	2	1	166	1	0	0	0	0	0	0	0	1	5197	1103	39	1		1	EPHA8	1	22919856	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1942751	22919856	226330765	9	30337											
EPHA8	2046	broad.mit.edu	37	chr1	22927255	22927255	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcggcgtggtcatgtgggaGgtgctggcctatggggagcg	4	10	20	7	3	1	0	1	0	0	0	2	2	1	2	1	7	2	1	1	7	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:22927255G>T	uc001bfx.1	+	14	2615	c.2490G>T	c.(2488-2490)GAG>GAT	p.E830D		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	830	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCATGTGGGAGGTGCTGGCCT	0.682													55	45					6.60958e-23	1.59345e-22	1	0	T	22927255	T	T	22927255	3	4	166	1	0	0	0	0	1	0	0	0	5197	991	35	4	2717	4	EPHA8	1	22927255	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	7399	22927255	226323366	10	30338											
C1QB	713	broad.mit.edu	37	chr1	22987522	22987522	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accatcaacgtccccctgcgCcgggaccagaccatccgctt	8	6	8	19	4	1	1	1	0	0	1	3	2	3	2	7	1	2	1	7	1	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:22987522C>A	uc001bgd.2	+	3	537	c.405C>A	c.(403-405)CGC>CGA	p.R135R		NM_000491	NP_000482	P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	135	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCCCCCTGCGCCGGGACCAGA	0.592													63	50					5.10652e-33	1.275e-32	1	0	A	22987522	A	A	22987522	2	1	166	1	0	0	0	0	0	0	0	1	1964	726	26	4		4	C1QB	1	22987522	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	60267	22987522	226263099	11	30339											
EPHB2	2048	broad.mit.edu	37	chr1	23234658	23234658	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaccccacctacaccagtgcCctggtaagatggaggcaggg	10	5	13	13	0	0	1	0	0	0	1	0	3	0	2	5	4	2	2	5	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:23234658C>A	uc009vqj.1	+	12	2494	c.2349C>A	c.(2347-2349)GCC>GCA	p.A783A	EPHB2_uc001bge.2_Silent_p.A784A|EPHB2_uc001bgf.2_Silent_p.A783A|EPHB2_uc010odu.1_Silent_p.A725A	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	783	Cytoplasmic (Potential).|Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		ACACCAGTGCCCTGGTAAGAT	0.493									Hereditary_Prostate_Cancer				24	22					9.95505e-16	2.17282e-15	1	0	A	23234658	A	A	23234658	2	1	166	1	0	0	0	0	0	0	0	1	5199	610	22	4		4	EPHB2	1	23234658	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	247136	23234658	226015963	12	30340											
E2F2	1870	broad.mit.edu	37	chr1	23857277	23857277	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaagccaaggcccggggcccTtgcagcatagcgagtaaggc	10	4	15	12	2	0	0	0	0	0	0	0	2	0	0	3	4	4	3	3	4	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:23857277T>A	uc001bhe.1	-	1	437	c.9A>T	c.(7-9)CAA>CAT	p.Q3H		NM_004091	NP_004082	Q14209	E2F2_HUMAN	E2F transcription factor 2	3					G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|skin(2)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		CCCGGGGCCCTTGCAGCATAG	0.721													9	7					0	0	0	0	A	23857277	A	A	23857277	3	1	166	1	0	0	0	0	1	0	0	0	4889	1606	56	5	1332	5	E2F2	1	23857277	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	622619	23857277	225393344	13	30341											
ARID1A	8289	broad.mit.edu	37	chr1	27089589	27089589	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atggacagcctggcatcccaCcttatggcacactccctcca	9	8	7	17	0	0	0	0	0	0	0	3	1	3	1	5	3	1	2	5	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:27089589C>T	uc001bmv.1	+	8	2918	c.2545C>T	c.(2545-2547)CCT>TCT	p.P849S	ARID1A_uc001bmt.1_Missense_Mutation_p.P849S|ARID1A_uc001bmu.1_Missense_Mutation_p.P849S|ARID1A_uc001bmw.1_Missense_Mutation_p.P466S	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	849					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGGCATCCCACCTTATGGCAC	0.587			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								17	43					0	0	0	0	T	27089589	T	T	27089589	3	4	166	1	0	0	0	0	1	0	0	0	913	507	18	4	2575	4	ARID1A	1	27089589	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3232312	27089589	222161032	14	30342											
CSMD2	114784	broad.mit.edu	37	chr1	34180246	34180246	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccccccaggcacgtgatgCgggcggtgccctccagacgg	5	5	15	16	4	0	2	0	1	0	1	1	2	1	2	5	4	3	1	5	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:34180246C>A	uc001bxn.1	-	21	3256	c.3227G>T	c.(3226-3228)CGC>CTC	p.R1076L	CSMD2_uc001bxm.1_Missense_Mutation_p.R1116L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1076	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCACGTGATGCGGGCGGTGCC	0.627													158	105					2.63717e-51	6.70408e-51	1	0	A	34180246	A	A	34180246	3	1	166	1	0	0	0	0	1	0	0	0	3962	768	27	3	7432	3	CSMD2	1	34180246	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	7090657	34180246	215070375	15	30343											
UTP11L	51118	broad.mit.edu	37	chr1	38484769	38484769	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcagagctccatctgctggaTttccaggggaagcaacagaa	12	8	11	10	0	2	2	1	0	1	2	4	4	4	4	2	3	4	3	2	3	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:38484769T>A	uc001ccn.3	+	5	472	c.381T>A	c.(379-381)GAT>GAA	p.D127E	UTP11L_uc009vvm.2_Missense_Mutation_p.D58E|UTP11L_uc010oil.1_RNA|UTP11L_uc001cco.3_Missense_Mutation_p.D58E	NM_016037	NP_057121	Q9Y3A2	UTP11_HUMAN	UTP11-like, U3 small nucleolar	127					induction of apoptosis|nerve growth factor receptor signaling pathway|nervous system development|rRNA processing	cytoplasm|extracellular space|nucleolus|small-subunit processome	protein binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ATCTGCTGGATTTCCAGGGGA	0.378													34	18					0	0	0	0	A	38484769	A	A	38484769	3	1	166	1	0	0	0	0	1	0	0	0	17162	1490	52	5	399	5	UTP11L	1	38484769	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	4304523	38484769	210765852	16	30344											
MACF1	23499	broad.mit.edu	37	chr1	39763349	39763349	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaacctccaagattccattAaacgaaaatattcctgtgac	15	10	6	10	1	0	2	0	1	0	1	3	4	3	3	4	1	2	0	4	1	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:39763349A>T	uc010ois.1	+	22	2633	c.2428A>T	c.(2428-2430)AAA>TAA	p.K810*	MACF1_uc001cda.1_Nonsense_Mutation_p.K718*|MACF1_uc001cdc.1_5'Flank|MACF1_uc009vvq.1_5'Flank|MACF1_uc001cdb.1_5'Flank	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	810					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGATTCCATTAAACGAAAATA	0.463													46	26					0	0	0	0	T	39763349	T	T	39763349	4	4	166	1	0	0	0	0	0	1	0	0	9195	363	13	5	2506	5	MACF1	1	39763349	Nonsense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1278580	39763349	209487272	17	30345											
TIE1	7075	broad.mit.edu	37	chr1	43770797	43770798	+	Missense_Mutation	DNP	CG	AT	AT																															gcgtgggcggtgctggggcgCggcgcacgcgcgtcatctac																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:43770797_43770798CG>AT	uc001ciu.2	+	2	413_414	c.334_335CG>AT	c.(334-336)CGG>ATG	p.R112M	TIE1_uc010okd.1_Missense_Mutation_p.R112M|TIE1_uc010oke.1_Missense_Mutation_p.R67M|TIE1_uc009vwq.2_Missense_Mutation_p.R112M|TIE1_uc010okf.1_Translation_Start_Site|TIE1_uc010okg.1_5'Flank|TIE1_uc010oka.1_Missense_Mutation_p.R112M|TIE1_uc010okb.1_Missense_Mutation_p.R112M|TIE1_uc010okc.1_Missense_Mutation_p.R112M	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	112	Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGCTGGGGCGCGGCGCACGCGC	0.703													12	16					0	0	0	0	AT	43770798	AT	AT	43770797	3	1	166	1	0	0	0	0	1	0	0	0	15959	759	27	3	340	3	TIE1	1	43770797	Missense_Mutation	DNP	CG	TCGA-CR-7402-01A-11D-2012-08	4007448	43770797	205479824	18	30346											
TAL1	6886	broad.mit.edu	37	chr1	47689705	47689705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctccatctcatagggggaaGgtctcctcttcactcgattg	7	13	9	12	1	5	0	2	0	4	0	9	2	5	1	2	3	0	0	2	3	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:47689705G>A	uc001cqx.2	-	3	1089	c.512C>T	c.(511-513)CCT>CTT	p.P171L	TAL1_uc009vyq.2_5'UTR|TAL1_uc001cqy.2_Missense_Mutation_p.P171L|TAL1_uc001cra.1_RNA|TAL1_uc001cqz.1_RNA	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	171					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1						ATAGGGGGAAGGTCTCCTCTT	0.572			T	TRD@|SIL	lymphoblastic leukemia/biphasic								61	52					0	0	0	0	A	47689705	A	A	47689705	3	1	166	1	0	0	0	0	1	0	0	0	15607	1000	35	4	491	4	TAL1	1	47689705	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3918908	47689705	201560916	19	30347											
ELAVL4	1996	broad.mit.edu	37	chr1	50661318	50661319	+	Frame_Shift_Ins	INS	-	A	A																															ggctgaatggccagaagcccINSagcggtgctacggaaccgat																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:50661318_50661319insA	uc001csb.2	+	5	862_863	c.594_595insA	c.(592-597)CCCAGCfs	p.P198fs	ELAVL4_uc001cry.3_Frame_Shift_Ins_p.P201fs|ELAVL4_uc001crz.3_Frame_Shift_Ins_p.P198fs|ELAVL4_uc001csa.3_Frame_Shift_Ins_p.P215fs|ELAVL4_uc001csc.3_Frame_Shift_Ins_p.P198fs|ELAVL4_uc009vyu.2_Frame_Shift_Ins_p.P203fs|ELAVL4_uc010omz.1_Frame_Shift_Ins_p.P203fs	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	198_199	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						GCCAGAAGCCCAGCGGTGCTAC	0.569													---	---	---								A	50661319	A	A	50661318	7	5	166	1	0	1	1	0	0	0	0	0	5076	581	21	0	711	0	ELAVL4	1	50661318	Frame_Shift_Ins	INS	-	TCGA-CR-7402-01A-11D-2012-08	2971613	50661318	198589303	20	30348											
CYB5RL	606495	broad.mit.edu	37	chr1	54645006	54645006	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcccgtgcccgcagccAgcaagaggagctcaccatac	10	3	11	17	2	1	1	1	0	0	1	1	2	1	2	5	2	5	3	5	2	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:54645006A>T	uc009vzo.2	-	7	880	c.560T>A	c.(559-561)CTG>CAG	p.L187Q	CYB5RL_uc001cww.2_Missense_Mutation_p.L77Q|CYB5RL_uc001cwx.3_RNA|CYB5RL_uc001cwy.3_Missense_Mutation_p.L39Q	NM_001031672	NP_001026842	Q6IPT4	NB5R5_HUMAN	cytochrome b5 reductase-like	187	FAD (By similarity).						cytochrome-b5 reductase activity				0						GCCCGCAGCCAGCAAGAGGAG	0.542													9	12					0	0	0	0	T	54645006	T	T	54645006	3	4	166	1	0	0	0	0	1	0	0	0	4147	188	7	5	395	5	CYB5RL	1	54645006	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	3983688	54645006	194605615	21	30349											
KANK4	163782	broad.mit.edu	37	chr1	62728768	62728768	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaaccacttctgacctgtCtccagcagcagcttcacgat	9	10	7	15	1	3	1	1	1	2	0	4	2	3	1	3	0	5	4	3	0	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:62728768C>T	uc001dah.3	-	7	2912	c.2535G>A	c.(2533-2535)GAG>GAA	p.E845E	KANK4_uc001dai.3_Silent_p.E217E|KANK4_uc001daf.3_5'UTR|KANK4_uc001dag.3_Silent_p.E201E	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	845	ANK 1.									ovary(3)|skin(2)|lung(1)	6						TCTGACCTGTCTCCAGCAGCA	0.428													10	10					0	0	0	0	T	62728768	T	T	62728768	2	4	166	1	0	0	0	0	0	0	0	1	8018	912	32	2		2	KANK4	1	62728768	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8083762	62728768	186521853	22	30350											
CACHD1	57685	broad.mit.edu	37	chr1	65138857	65138857	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acaggtgcttcataatggagGacaggggttatctggtggcg	9	10	16	6	1	2	0	1	0	1	0	2	2	2	2	0	7	1	2	0	7	2	3	rs148780022		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:65138857G>T	uc001dbo.1	+	18	2479	c.2374G>T	c.(2374-2376)GAC>TAC	p.D792Y	CACHD1_uc001dbp.1_Missense_Mutation_p.D547Y|CACHD1_uc001dbq.1_Missense_Mutation_p.D547Y|CACHD1_uc010opa.1_Missense_Mutation_p.D36Y	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	843	Extracellular (Potential).|Cache 2.				calcium ion transport	integral to membrane				ovary(2)	2						CATAATGGAGGACAGGGGTTA	0.453													99	79					2.65435e-51	6.73902e-51	1	0	T	65138857	T	T	65138857	3	4	166	1	0	0	0	0	1	0	0	0	2549	1174	41	2	2444	2	CACHD1	1	65138857	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2410089	65138857	184111764	23	30351											
LEPR	3953	broad.mit.edu	37	chr1	66036415	66036415	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcaagatagaaactgctcCttatgtgcagacaacattga	15	9	9	8	0	0	4	0	1	0	3	1	5	1	4	1	0	5	3	1	0	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:66036415C>A	uc001dci.2	+	4	502	c.300C>A	c.(298-300)TCC>TCA	p.S100S	LEPR_uc001dcg.2_Silent_p.S100S|LEPR_uc001dch.2_Silent_p.S100S|LEPR_uc009waq.2_Silent_p.S100S|LEPR_uc001dcj.2_Silent_p.S100S|LEPR_uc001dck.2_Silent_p.S100S	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	100	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GAAACTGCTCCTTATGTGCAG	0.333													36	23					1.96642e-18	4.48682e-18	1	0	A	66036415	A	A	66036415	2	1	166	1	0	0	0	0	0	0	0	1	8768	668	24	4		4	LEPR	1	66036415	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	897558	66036415	183214206	24	30352											
WDR78	79819	broad.mit.edu	37	chr1	67359072	67359072	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtaaagaggtcggggagtaaCatcagttccatttatgtcaa	13	11	11	6	1	2	1	2	0	0	1	4	2	3	2	1	3	1	3	1	3	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:67359072C>A	uc001dcx.2	-	3	426	c.370G>T	c.(370-372)GTT>TTT	p.V124F	WDR78_uc001dcy.2_Missense_Mutation_p.V124F|WDR78_uc001dcz.2_Missense_Mutation_p.V124F|WDR78_uc009wax.2_5'Flank	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	124										ovary(2)	2						CGGGGAGTAACATCAGTTCCA	0.343													26	19					2.48779e-11	4.94531e-11	1	0	A	67359072	A	A	67359072	3	1	166	1	0	0	0	0	1	0	0	0	17396	478	17	4	2293	4	WDR78	1	67359072	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1322657	67359072	181891549	25	30353											
LRRC7	57554	broad.mit.edu	37	chr1	70493932	70493932	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	taaaatctgttcaaaatttgGtgggtaagccaagccatgga	14	11	10	6	0	2	0	1	0	1	0	2	1	2	1	2	3	2	2	2	3	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:70493932G>A	uc001dep.2	+	16	1789	c.1759G>A	c.(1759-1761)GTG>ATG	p.V587M	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	587						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TCAAAATTTGGTGGGTAAGCC	0.378													17	54					0	0	0	0	A	70493932	A	A	70493932	3	1	166	1	0	0	0	0	1	0	0	0	9070	1261	44	4	1821	4	LRRC7	1	70493932	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3134860	70493932	178756689	26	30354											
FPGT	8790	broad.mit.edu	37	chr1	74670412	74670412	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tacaggtcttgccatcgtttCcttcataagcccagcataga	10	12	7	12	1	2	1	1	0	1	1	4	1	3	1	3	1	4	2	3	1	3	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:74670412C>G	uc001dgb.1	+	4	718	c.681C>G	c.(679-681)TTC>TTG	p.F227L	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	227					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						GCCATCGTTTCCTTCATAAGC	0.403													15	47					0	0	0	0	G	74670412	G	G	74670412	3	3	166	1	0	0	0	0	1	0	0	0	6071	854	30	2	695	2	FPGT	1	74670412	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4176480	74670412	174580209	27	30355											
IFI44L	10964	broad.mit.edu	37	chr1	79106756	79106756	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgattgcagtgaggttCttcaagacaactttttaaac	12	14	9	6	0	2	3	1	2	1	1	2	4	2	4	0	2	3	2	0	2	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:79106756C>A	uc010oro.1	+	7	1278	c.1099C>A	c.(1099-1101)CTT>ATT	p.L367I	IFI44L_uc010orp.1_Missense_Mutation_p.L104I|IFI44L_uc010orq.1_Missense_Mutation_p.L104I	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	367						cytoplasm					0						CAGTGAGGTTCTTCAAGACAA	0.313													61	34					1.46168e-27	3.57665e-27	1	0	A	79106756	A	A	79106756	3	1	166	1	0	0	0	0	1	0	0	0	7557	913	32	2	1121	2	IFI44L	1	79106756	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4436344	79106756	170143865	28	30356											
CCBL2	56267	broad.mit.edu	37	chr1	89430571	89430571	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagagatccatatgctcctaCtgtcacaaggatttctttat	12	14	6	9	0	2	1	1	0	1	1	4	3	4	2	2	1	2	1	2	1	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:89430571C>A	uc001dmp.2	-	5	771	c.394G>T	c.(394-396)GTA>TTA	p.V132L	CCBL2_uc001dmq.2_Missense_Mutation_p.V98L|CCBL2_uc001dmr.2_5'UTR	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	132					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TATGCTCCTACTGTCACAAGG	0.333													26	24					7.07758e-08	1.29888e-07	1	0	A	89430571	A	A	89430571	3	1	166	1	0	0	0	0	1	0	0	0	2745	565	20	4	1010	4	CCBL2	1	89430571	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	10323815	89430571	159820050	29	30357											
DPYD	1806	broad.mit.edu	37	chr1	97700482	97700482	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattccaccagtagccaaaaTgggaaatccaggcagagcac	16	5	9	11	0	0	1	0	0	0	1	2	2	2	2	4	2	2	3	4	2	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:97700482T>A	uc001drv.2	-	19	2505	c.2368A>T	c.(2368-2370)ATT>TTT	p.I790F		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	790					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GTAGCCAAAATGGGAAATCCA	0.463													39	27					0	0	0	0	A	97700482	A	A	97700482	3	1	166	1	0	0	0	0	1	0	0	0	4767	1464	51	5	729	5	DPYD	1	97700482	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	8269911	97700482	151550139	30	30358											
DPYD	1806	broad.mit.edu	37	chr1	97771816	97771816	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggaatctgaacagcttgcCtaacccagcggcagatgttc	12	8	10	11	1	1	2	0	1	1	1	2	3	1	3	2	2	5	3	2	2	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:97771816C>A	uc001drv.2	-	17	2233	c.2096G>T	c.(2095-2097)AGG>ATG	p.R699M		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	699					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AACAGCTTGCCTAACCCAGCG	0.423													41	157					6.45866e-13	1.3159e-12	1	0	A	97771816	A	A	97771816	3	1	166	1	0	0	0	0	1	0	0	0	4767	681	24	4	1009	4	DPYD	1	97771816	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	71334	97771816	151478805	31	30359											
LPPR5	163404	broad.mit.edu	37	chr1	99418732	99418732	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtacaggcctcttccccaCtgatgaattgtgtatactgc	9	12	8	12	0	1	2	0	2	1	0	2	2	2	2	3	1	3	2	3	1	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:99418732C>A	uc001dsb.2	-	3	737	c.515G>T	c.(514-516)AGT>ATT	p.S172I	LPPR5_uc001dsc.2_Missense_Mutation_p.S172I	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	172						integral to membrane	hydrolase activity				0						CTCTTCCCCACTGATGAATTG	0.478													32	24					1.88708e-17	4.24648e-17	1	0	A	99418732	A	A	99418732	3	1	166	1	0	0	0	0	1	0	0	0	8978	565	20	4	466	4	LPPR5	1	99418732	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1646916	99418732	149831889	32	30360											
CELSR2	1952	broad.mit.edu	37	chr1	109803804	109803804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcgagaagccctactgccagGtgaccacgcgcagcttcccc	8	6	10	17	3	0	2	0	1	0	1	2	3	1	2	5	1	4	2	5	1	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:109803804G>A	uc001dxa.3	+	3	4160	c.4099G>A	c.(4099-4101)GTG>ATG	p.V1367M		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1367	Extracellular (Potential).|Laminin G-like 1.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTACTGCCAGGTGACCACGCG	0.632													28	67					0	0	0	0	A	109803804	A	A	109803804	3	1	166	1	0	0	0	0	1	0	0	0	3237	1261	44	4	4109	4	CELSR2	1	109803804	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	10385072	109803804	139446817	33	30361											
AMPD2	271	broad.mit.edu	37	chr1	110170415	110170415	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagtcattctgctaccgcCggctgcagtacctgagctcc	8	9	10	14	2	2	1	1	1	1	0	3	2	3	1	4	1	5	5	4	1	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:110170415C>A	uc009wfh.1	+	10	1674	c.1132C>A	c.(1132-1134)CGG>AGG	p.R378R	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Silent_p.R297R|AMPD2_uc001dyc.1_Silent_p.R378R|AMPD2_uc010ovr.1_Silent_p.R303R|AMPD2_uc010ovs.1_Silent_p.R260R|AMPD2_uc001dyd.1_Silent_p.R259R|AMPD2_uc001dye.1_5'Flank	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	378					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		CTGCTACCGCCGGCTGCAGTA	0.557													13	41					1.36491e-13	2.83392e-13	1	0	A	110170415	A	A	110170415	2	1	166	1	0	0	0	0	0	0	0	1	586	643	23	3		3	AMPD2	1	110170415	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	366611	110170415	139080206	34	30362											
GSTM4	2948	broad.mit.edu	37	chr1	110203833	110203833	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtccagccgcttcctccCaaaacctctgtacacaaggg	11	7	8	15	1	1	0	0	0	1	0	4	1	4	0	5	1	3	2	5	1	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:110203833C>G	uc001dyf.2	+	8	928	c.614C>G	c.(613-615)CCA>CGA	p.P205R	GSTM4_uc001dyg.2_Missense_Mutation_p.P101R|GSTM4_uc009wfj.2_Missense_Mutation_p.P144R|GSTM4_uc001dyh.2_Intron|GSTM2_uc001dyi.2_Intron	NM_000850	NP_000841	Q03013	GSTM4_HUMAN	glutathione S-transferase mu 4 isoform 1	205	GST C-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	CGCTTCCTCCCAAAACCTCTG	0.577													16	164					0	0	0	0	G	110203833	G	G	110203833	3	3	166	1	0	0	0	0	1	0	0	0	6879	594	21	4	644	4	GSTM4	1	110203833	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	33418	110203833	139046788	35	30363											
PTPN22	26191	broad.mit.edu	37	chr1	114376998	114376998	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttccaccccattccagtGatgttccaatttttaccttc	8	16	4	13	0	0	1	0	1	0	0	4	1	3	1	6	0	1	2	6	0	2	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:114376998G>T	uc001eds.2	-	15	2088	c.1958C>A	c.(1957-1959)TCA>TAA	p.S653*	PTPN22_uc009wgq.2_Nonsense_Mutation_p.S598*|PTPN22_uc010owo.1_Nonsense_Mutation_p.S409*|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Nonsense_Mutation_p.S653*|PTPN22_uc009wgs.2_Nonsense_Mutation_p.S526*|PTPN22_uc001edu.2_Nonsense_Mutation_p.S653*	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	653					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCATTCCAGTGATGTTCCAAT	0.363													26	71					1.1804e-14	2.52298e-14	1	0	T	114376998	T	T	114376998	4	4	166	1	0	0	0	0	0	1	0	0	12852	1294	45	2	516	2	PTPN22	1	114376998	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4173165	114376998	134873623	36	30364											
AP4B1	10717	broad.mit.edu	37	chr1	114442738	114442738	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaactatgcaagatctggCgtacatgacaaagagcaaca	17	7	9	8	1	1	3	0	1	1	2	1	3	1	3	0	1	5	4	0	1	7	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:114442738C>T	uc001eeb.2	-	5	1045	c.902G>A	c.(901-903)CGC>CAC	p.R301H	uc001edv.1_RNA|AP4B1_uc001eec.2_Missense_Mutation_p.R133H|AP4B1_uc001eed.2_Missense_Mutation_p.R301H|AP4B1_uc010owp.1_Missense_Mutation_p.R202H|AP4B1_uc001eea.1_Missense_Mutation_p.R95H|AP4B1_uc001eee.1_5'Flank|AP4B1_uc010owq.1_Missense_Mutation_p.R208H	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	301					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAGATCTGGCGTACATGACA	0.473													41	92					0	0	0	0	T	114442738	T	T	114442738	3	4	166	1	0	0	0	0	1	0	0	0	751	768	27	1	1341	1	AP4B1	1	114442738	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	65740	114442738	134807883	37	30365											
SYCP1	6847	broad.mit.edu	37	chr1	115527424	115527424	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacccattgaagaaagtaaaAaaaagagaaaaatggccttt	21	8	7	5	0	0	3	0	1	0	2	0	4	0	3	2	1	1	1	2	1	9	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:115527424A>T	uc001efr.2	+	30	2847	c.2638A>T	c.(2638-2640)AAA>TAA	p.K880*	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Nonsense_Mutation_p.K880*|SYCP1_uc009wgw.2_Nonsense_Mutation_p.K855*	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	880	Nuclear localization signal (Potential).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGAAAGTAAAAAAAAGAGAAA	0.249													31	66					0	0	0	0	T	115527424	T	T	115527424	4	4	166	1	0	0	0	0	0	1	0	0	15497	15	1	5	2752	5	SYCP1	1	115527424	Nonsense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1084686	115527424	133723197	38	30366											
NGF	4803	broad.mit.edu	37	chr1	115828838	115828838	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgagttccagtgctttgaGtcaatgccccggcacccgct	7	11	10	13	2	1	2	1	2	0	0	2	2	2	2	4	1	2	4	4	1	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:115828838G>A	uc001efu.1	-	3	748	c.579C>T	c.(577-579)GAC>GAT	p.D193D		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	193					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	AGTGCTTTGAGTCAATGCCCC	0.507													23	50					0	0	0	0	A	115828838	A	A	115828838	2	1	166	1	0	0	0	0	0	0	0	1	10449	1020	36	4		4	NGF	1	115828838	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	301414	115828838	133421783	39	30367											
IGSF3	3321	broad.mit.edu	37	chr1	117142746	117142746	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccttctcgatggcagttcGggttcggaagctggaggacc	7	9	15	10	3	1	0	0	0	1	0	4	4	1	3	2	5	2	4	2	5	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:117142746G>C	uc001egr.1	-	7	2551	c.1846C>G	c.(1846-1848)CGA>GGA	p.R616G	IGSF3_uc001egq.1_Missense_Mutation_p.R636G|IGSF3_uc001egs.1_Missense_Mutation_p.R289G	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	616	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		ATGGCAGTTCGGGTTCGGAAG	0.627													10	20					0	0	0	0	C	117142746	C	C	117142746	3	2	166	1	0	0	0	0	1	0	0	0	7640	1124	39	3	1758	3	IGSF3	1	117142746	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1313908	117142746	132107875	40	30368											
HSD3B2	3284	broad.mit.edu	37	chr1	119958051	119958051	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggattggccacgatgggctgGagctgccttgtgacaggagc	7	8	17	9	1	0	1	0	1	0	0	0	5	0	4	2	5	3	2	2	5	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:119958051G>T	uc001ehs.2	+	1	782	c.9G>T	c.(7-9)TGG>TGT	p.W3C	HSD3B2_uc001eht.2_Missense_Mutation_p.W3C|HSD3B2_uc001ehu.2_Missense_Mutation_p.W3C	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	3					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CGATGGGCTGGAGCTGCCTTG	0.552													24	71					7.87624e-14	1.64578e-13	1	0	T	119958051	T	T	119958051	3	4	166	1	0	0	0	0	1	0	0	0	7430	1183	41	2	11	2	HSD3B2	1	119958051	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2815305	119958051	129292570	41	30369											
PDE4DIP	9659	broad.mit.edu	37	chr1	145075769	145075769	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgcgtcgcgtccccggaccGgtaaggcgtgtagtgagccc	5	7	15	14	7	0	1	0	1	0	0	3	2	1	2	4	3	1	2	4	3	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:145075769G>C	uc001emh.2	-	1	311	c.94C>G	c.(94-96)CGG>GGG	p.R32G	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Missense_Mutation_p.R32G|PDE4DIP_uc001emk.2_Missense_Mutation_p.R32G	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCCCGGACCGGTAAGGCGTG	0.716			T	PDGFRB	MPD								11	70					0	0	0	0	C	145075769	C	C	145075769	3	2	166	1	0	0	0	0	1	0	0	0	11697	1115	39	3	8718	3	PDE4DIP	1	145075769	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	25117718	145075769	104174852	42	30370											
TXNIP	10628	broad.mit.edu	37	chr1	145439871	145439874	+	Frame_Shift_Del	DEL	AAAG	-	-																															agccagccaactcaagagacAaagaaaaactttgaagtagt																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:145439871_145439874delAAAG	uc001enn.3	+	3	758_761	c.417_420delAAAG	c.(415-420)ACAAAGfs	p.T139fs	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Frame_Shift_Del_p.T84fs	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	139_140					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTCAAGAGACAAAGAAAAACTTTG	0.441													---	---	---								-	145439874	-	-	145439871	7	5	166	1	0	1	0	1	0	0	0	0	16871	117	5	0	427	0	TXNIP	1	145439871	Frame_Shift_Del	DEL	AAAG	TCGA-CR-7402-01A-11D-2012-08	364102	145439871	103810750	43	30371											
LIX1L	128077	broad.mit.edu	37	chr1	145497393	145497393	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttctgttcctctactaccagGgcaacagggaggaagctgac	10	9	11	11	0	2	1	0	1	2	0	3	3	3	3	2	3	4	3	2	3	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:145497393G>T	uc001enr.2	+	4	672	c.598G>T	c.(598-600)GGC>TGC	p.G200C	NBPF10_uc001emp.3_Intron|LIX1L_uc009wiu.1_5'Flank	NM_153713	NP_714924	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse) like	200										ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTACTACCAGGGCAACAGGGA	0.353													10	41					0.000978159	0.00160569	1	0	T	145497393	T	T	145497393	3	4	166	1	0	0	0	0	1	0	0	0	8874	1246	43	4	612	4	LIX1L	1	145497393	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	57522	145497393	103753228	44	30372											
GJA5	2702	broad.mit.edu	37	chr1	147231343	147231343	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcccaggaagctccaatcgcCcatcttggcacagccaggga	10	6	10	15	1	1	0	0	0	1	0	4	2	3	2	4	3	2	2	4	3	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:147231343C>A	uc001eps.1	-	2	145	c.4G>T	c.(4-6)GGC>TGC	p.G2C	GJA5_uc001ept.1_Missense_Mutation_p.G2C	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	2	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CTCCAATCGCCCATCTTGGCA	0.493													16	69					1.99824e-07	3.61638e-07	1	0	A	147231343	A	A	147231343	3	1	166	1	0	0	0	0	1	0	0	0	6441	623	22	4	1076	4	GJA5	1	147231343	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1733950	147231343	102019278	45	30373											
HRNR	388697	broad.mit.edu	37	chr1	152192079	152192079	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagccagacccatgttggcCgtagctggaagagtgcccaa	10	6	14	11	1	0	2	0	0	0	2	0	4	0	4	4	3	3	3	4	3	3	2	rs141565920		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:152192079C>T	uc001ezt.1	-	3	2102	c.2026G>A	c.(2026-2028)GGC>AGC	p.G676S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	676	6.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGTTGGCCGTAGCTGGAA	0.587													90	178					0	0	0	0	T	152192079	T	T	152192079	3	4	166	1	0	0	0	0	1	0	0	0	7398	652	23	1	6530	1	HRNR	1	152192079	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4960736	152192079	97058542	46	30374											
CRNN	49860	broad.mit.edu	37	chr1	152382869	152382869	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctgggtctgagttccaGatccagtcacagtctcacct	7	11	9	14	0	3	2	2	1	2	1	6	2	5	2	4	1	1	1	4	1	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:152382869G>T	uc001ezx.2	-	3	763	c.689C>A	c.(688-690)TCT>TAT	p.S230Y		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	230	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGAGTTCCAGATCCAGTCAC	0.577													98	211					4.7146e-34	1.18318e-33	1	0	T	152382869	T	T	152382869	3	4	166	1	0	0	0	0	1	0	0	0	3907	942	33	2	802	2	CRNN	1	152382869	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	190790	152382869	96867752	47	30375											
SPRR1B	6699	broad.mit.edu	37	chr1	153004977	153004977	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgagccctgccaccccaaAgtgcccgagccctgccagcc	7	4	9	21	1	0	1	0	1	0	0	0	2	0	1	9	0	6	0	9	0	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:153004977A>G	uc001fba.2	+	2	220	c.156A>G	c.(154-156)AAA>AAG	p.K52K	SPRR1B_uc009wnx.1_RNA	NM_003125	NP_003116	P22528	SPR1B_HUMAN	small proline-rich protein 1B	52	6 X 8 AA approximate tandem repeats.|3.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCACCCCAAAGTGCCCGAGC	0.627													13	122					0	0	0	0	G	153004977	G	G	153004977	2	3	166	1	0	0	0	0	0	0	0	1	15162	69	3	5		5	SPRR1B	1	153004977	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	622108	153004977	96245644	48	30376											
NES	10763	broad.mit.edu	37	chr1	156642721	156642721	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctctggagcctgtttcctcCcaccctgtgtctggagcaga	5	11	11	14	0	2	1	0	0	2	1	4	3	4	3	4	2	2	3	4	2	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:156642721C>A	uc001fpq.2	-	4	1392	c.1259G>T	c.(1258-1260)GGG>GTG	p.G420V		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	420	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGTTTCCTCCCACCCTGTGT	0.657													24	67					4.47668e-21	1.05587e-20	1	0	A	156642721	A	A	156642721	3	1	166	1	0	0	0	0	1	0	0	0	10391	623	22	4	3610	4	NES	1	156642721	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3637744	156642721	92607900	49	30377											
OR6K6	128371	broad.mit.edu	37	chr1	158724824	158724824	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctaactggaaacctaataatGttcattgtcatccaggtggg	12	12	9	8	0	2	0	2	0	0	0	3	1	3	1	2	3	2	1	2	3	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:158724824G>T	uc001fsw.1	+	1	219	c.219G>T	c.(217-219)ATG>ATT	p.M73I		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	73	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					ACCTAATAATGTTCATTGTCA	0.468													32	125					1.45844e-13	3.02171e-13	1	0	T	158724824	T	T	158724824	3	4	166	1	0	0	0	0	1	0	0	0	11258	1377	48	4	221	4	OR6K6	1	158724824	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2082103	158724824	90525797	50	30378											
CCDC19	25790	broad.mit.edu	37	chr1	159850454	159850454	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatgcgcttaatctcagcttGcatcttcagtttttgttgct	6	18	8	9	1	3	0	2	0	2	0	4	1	3	0	0	0	4	6	0	0	1	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:159850454G>A	uc001fui.2	-	8	952	c.934C>T	c.(934-936)CAA>TAA	p.Q312*	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Nonsense_Mutation_p.Q227*|CCDC19_uc001ful.2_Nonsense_Mutation_p.Q227*|CCDC19_uc009wtc.1_Nonsense_Mutation_p.Q298*	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	312	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			ATCTCAGCTTGCATCTTCAGT	0.468													16	65					0	0	0	0	A	159850454	A	A	159850454	4	1	166	1	0	0	0	0	0	1	0	0	2808	1328	46	4	741	4	CCDC19	1	159850454	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1125630	159850454	89400167	51	30379											
DDR2	4921	broad.mit.edu	37	chr1	162724444	162724444	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaagaaggggatggagcctgGtgccctgagattccagtgga	10	7	17	7	0	0	2	0	1	0	2	1	7	1	5	3	5	2	0	3	5	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:162724444G>A	uc001gcf.2	+	6	681	c.216G>A	c.(214-216)TGG>TGA	p.W72*	DDR2_uc001gcg.2_Nonsense_Mutation_p.W72*	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	72	Extracellular (Potential).|F5/8 type C.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			ATGGAGCCTGGTGCCCTGAGA	0.557													38	74					0	0	0	0	A	162724444	A	A	162724444	4	1	166	1	0	0	0	0	0	1	0	0	4354	1270	44	4	226	4	DDR2	1	162724444	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2873990	162724444	86526177	52	30380											
RXRG	6258	broad.mit.edu	37	chr1	165377463	165377464	+	Splice_Site	DNP	CC	AA	AA																															ctggggttgaagggcggttaCctgggttaaagagtacaatg																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:165377463_165377464CC>AA	uc001gda.2	-	8	1438	c.1138_splice	c.e8+1	p.D380_splice		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	AGGGCGGTTACCTGGGTTAAAG	0.515													34	66					0	0	0	0	AA	165377464	AA	AA	165377463	5	1	166	1	0	0	0	0	0	0	1	0	13830	521	18	4	264	4	RXRG	1	165377463	Splice_Site	DNP	CC	TCGA-CR-7402-01A-11D-2012-08	2653019	165377463	83873158	53	30381											
DUSP27	92235	broad.mit.edu	37	chr1	167097589	167097589	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggaagatgtggaagagtCatccaagtcagacttctctg	11	10	12	8	0	3	3	2	0	1	3	5	5	4	5	1	2	0	0	1	2	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:167097589C>T	uc001geb.1	+	5	3221	c.3221C>T	c.(3220-3222)TCA>TTA	p.S1074L		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1074					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GTGGAAGAGTCATCCAAGTCA	0.522													10	14					0	0	0	0	T	167097589	T	T	167097589	3	4	166	1	0	0	0	0	1	0	0	0	4846	838	29	2	3239	2	DUSP27	1	167097589	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1720126	167097589	82153032	54	30382											
SELL	6402	broad.mit.edu	37	chr1	169673747	169673747	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagatgaccagtttccaaatGgtccacaggtggtttcttca	10	12	10	9	0	2	2	1	1	1	1	4	3	4	2	3	3	0	2	3	3	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:169673747G>T	uc001ggk.2	-	5	926	c.728C>A	c.(727-729)CCA>CAA	p.P243Q	C1orf112_uc001ggj.2_Intron|SELL_uc010pls.1_Missense_Mutation_p.P196Q|SELL_uc001ggl.1_Missense_Mutation_p.P256Q	NM_000655	NP_000646	P14151	LYAM1_HUMAN	selectin L precursor	243	Extracellular (Potential).|Sushi 1.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding				0	all_hematologic(923;0.208)					GTTTCCAAATGGTCCACAGGT	0.463													3	3					0.004672	0.00754293	1	0	T	169673747	T	T	169673747	3	4	166	1	0	0	0	0	1	0	0	0	14081	1348	47	4	410	4	SELL	1	169673747	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2576158	169673747	79576874	55	30383											
KIFAP3	22920	broad.mit.edu	37	chr1	169941740	169941740	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgagatatgctggagcctCtgaataaaaatggttaaaga	16	11	10	4	0	1	3	0	2	1	2	1	5	1	4	1	2	2	2	1	2	8	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:169941740C>G	uc001ggv.2	-	17	2169	c.1898_splice	c.e17-1	p.Q633_splice	KIFAP3_uc010plx.1_Splice_Site_p.Q335_splice	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3						blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCTGGAGCCTCTGAATAAAAA	0.279													7	18					0	0	0	0	G	169941740	G	G	169941740	5	3	166	1	0	0	0	0	0	0	1	0	8350	927	32	2	497	2	KIFAP3	1	169941740	Splice_Site	SNP	C	TCGA-CR-7402-01A-11D-2012-08	267993	169941740	79308881	56	30384											
C1orf129	80133	broad.mit.edu	37	chr1	170961417	170961417	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggggaaatggaggacaccGtaacggaagggaaacgtttc	13	6	15	7	3	0	0	0	0	0	0	1	5	0	5	1	6	2	2	1	6	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:170961417G>A	uc001ghg.2	+	12	1271	c.1141G>A	c.(1141-1143)GTA>ATA	p.V381I	C1orf129_uc009wvy.2_Missense_Mutation_p.V188I|C1orf129_uc010plz.1_Missense_Mutation_p.V381I	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	381							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGAGGACACCGTAACGGAAGG	0.473													17	75					0	0	0	0	A	170961417	A	A	170961417	3	1	166	1	0	0	0	0	1	0	0	0	2005	1145	40	1	1183	1	C1orf129	1	170961417	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1019677	170961417	78289204	57	30385											
TNFSF18	8995	broad.mit.edu	37	chr1	173010716	173010716	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacctcaaaaggagctacatCattgtagtttgcattgggag	12	11	10	8	0	2	0	2	0	0	0	2	2	2	2	1	2	3	4	1	2	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:173010716C>T	uc001giu.2	-	3	392	c.391G>A	c.(391-393)GAT>AAT	p.D131N		NM_005092	NP_005083	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily,	131	Extracellular (Potential).				anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						GGAGCTACATCATTGTAGTTT	0.383													40	92					0	0	0	0	T	173010716	T	T	173010716	3	4	166	1	0	0	0	0	1	0	0	0	16375	826	29	2	212	2	TNFSF18	1	173010716	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2049299	173010716	76239905	58	30386											
TNN	63923	broad.mit.edu	37	chr1	175049390	175049390	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agccaggtggatcactacctCctcagctactaccccctggg	8	8	9	16	0	2	0	2	0	0	0	3	1	3	1	5	3	5	1	5	3	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:175049390C>A	uc001gkl.1	+	4	989	c.876C>A	c.(874-876)CTC>CTA	p.L292L	TNN_uc010pmx.1_Silent_p.L292L	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	292	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ATCACTACCTCCTCAGCTACT	0.592													18	37					5.3912e-06	9.37601e-06	1	0	A	175049390	A	A	175049390	2	1	166	1	0	0	0	0	0	0	0	1	16389	842	30	2		2	TNN	1	175049390	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2038674	175049390	74201231	59	30387											
TNN	63923	broad.mit.edu	37	chr1	175054604	175054604	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagaggagagctggagggcaAgccgatcctcctgaatggca	11	5	16	9	1	0	3	0	1	0	2	2	7	2	4	3	4	2	3	3	4	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:175054604A>G	uc001gkl.1	+	6	1411	c.1298A>G	c.(1297-1299)AAG>AGG	p.K433R	TNN_uc010pmx.1_Missense_Mutation_p.K433R	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	433	Fibronectin type-III 2.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CTGGAGGGCAAGCCGATCCTC	0.532													6	16					0	0	0	0	G	175054604	G	G	175054604	3	3	166	1	0	0	0	0	1	0	0	0	16389	72	3	5	1316	5	TNN	1	175054604	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	5214	175054604	74196017	60	30388											
TNN	63923	broad.mit.edu	37	chr1	175067479	175067479	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccttccagatattgacagcCccaaaaacctggtgactgac	12	9	7	13	0	0	4	0	3	0	1	2	4	2	4	5	1	2	0	5	1	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:175067479C>G	uc001gkl.1	+	9	1980	c.1867C>G	c.(1867-1869)CCC>GCC	p.P623A	TNN_uc010pmx.1_Missense_Mutation_p.P534A	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	623	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TATTGACAGCCCCAAAAACCT	0.507													40	122					0	0	0	0	G	175067479	G	G	175067479	3	3	166	1	0	0	0	0	1	0	0	0	16389	623	22	4	1897	4	TNN	1	175067479	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	12875	175067479	74183142	61	30389											
ABL2	27	broad.mit.edu	37	chr1	179077050	179077050	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacatagcctgagcagtagtCaagcagctggtgtccagtgt	10	9	12	10	0	1	1	1	1	0	0	2	1	2	1	2	1	4	4	2	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:179077050C>A	uc001gmj.3	-	12	3639	c.3352G>T	c.(3352-3354)GAC>TAC	p.D1118Y	ABL2_uc010pnf.1_Missense_Mutation_p.D1015Y|ABL2_uc010png.1_Missense_Mutation_p.D994Y|ABL2_uc010pnh.1_Missense_Mutation_p.D1097Y|ABL2_uc001gmg.3_Missense_Mutation_p.D1000Y|ABL2_uc001gmi.3_Missense_Mutation_p.D1103Y|ABL2_uc001gmh.3_Missense_Mutation_p.D1082Y|ABL2_uc010pne.1_Missense_Mutation_p.D979Y	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	1118	F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GAGCAGTAGTCAAGCAGCTGG	0.552			T	ETV6	AML								15	45					7.93312e-07	1.41354e-06	1	0	A	179077050	A	A	179077050	3	1	166	1	0	0	0	0	1	0	0	0	93	826	29	2	200	2	ABL2	1	179077050	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4009571	179077050	70173571	62	30390											
TDRD5	163589	broad.mit.edu	37	chr1	179632540	179632540	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attcttggcagccttcaggcCttgtaaatggaacgaaagta	12	11	10	8	1	2	0	1	0	1	0	2	2	2	1	2	3	2	3	2	3	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:179632540C>T	uc001gnf.1	+	15	2651	c.2401C>T	c.(2401-2403)CTT>TTT	p.L801F	TDRD5_uc010pnp.1_Missense_Mutation_p.L855F|TDRD5_uc001gnh.1_Missense_Mutation_p.L356F	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	801					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						GCCTTCAGGCCTTGTAAATGG	0.398													16	45					0	0	0	0	T	179632540	T	T	179632540	3	4	166	1	0	0	0	0	1	0	0	0	15799	681	24	4	2455	4	TDRD5	1	179632540	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	555490	179632540	69618081	63	30391											
CEP350	9857	broad.mit.edu	37	chr1	180061771	180061771	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttcactgtctggttctgaGagatcagtatcagaaaggtc	10	12	11	8	0	5	3	3	1	2	2	6	4	5	3	0	2	0	3	0	2	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:180061771G>C	uc001gnt.2	+	34	6914	c.6531G>C	c.(6529-6531)GAG>GAC	p.E2177D	CEP350_uc009wxl.2_Missense_Mutation_p.E2176D|CEP350_uc001gnv.2_Missense_Mutation_p.E312D|CEP350_uc001gnw.1_5'UTR|CEP350_uc001gnx.1_5'UTR	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2177						centrosome|nucleus|spindle				ovary(4)	4						CTGGTTCTGAGAGATCAGTAT	0.348													8	16					0	0	0	0	C	180061771	C	C	180061771	3	2	166	1	0	0	0	0	1	0	0	0	3269	933	33	2	6661	2	CEP350	1	180061771	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	429231	180061771	69188850	64	30392											
CACNA1E	777	broad.mit.edu	37	chr1	181705563	181705563	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgttcatcttcagcaccAccaacccgtaagccaccctc	11	8	4	18	1	3	0	2	0	1	0	4	0	3	0	5	0	3	3	5	0	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:181705563A>T	uc001gow.2	+	22	3580	c.3415A>T	c.(3415-3417)ACC>TCC	p.T1139S	CACNA1E_uc009wxs.2_Missense_Mutation_p.T1027S|CACNA1E_uc001gox.1_Missense_Mutation_p.T365S|CACNA1E_uc009wxt.2_Missense_Mutation_p.T365S	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1139	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CTTCAGCACCACCAACCCGTA	0.463													5	13					0	0	0	0	T	181705563	T	T	181705563	3	4	166	1	0	0	0	0	1	0	0	0	2554	159	6	5	3501	5	CACNA1E	1	181705563	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1643792	181705563	67545058	65	30393											
CACNA1E	777	broad.mit.edu	37	chr1	181754552	181754552	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaggcagcagctggaggaaCaggtgaaagtcaatgccagc	14	4	15	8	0	1	2	1	1	0	1	1	4	1	4	1	4	5	3	1	4	3	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:181754552C>G	uc001gow.2	+	42	5842	c.5677C>G	c.(5677-5679)CAG>GAG	p.Q1893E	CACNA1E_uc009wxs.2_Missense_Mutation_p.Q1781E|CACNA1E_uc009wxt.2_Missense_Mutation_p.Q1119E	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1893	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GCTGGAGGAACAGGTGAAAGT	0.537													6	19					0	0	0	0	G	181754552	G	G	181754552	3	3	166	1	0	0	0	0	1	0	0	0	2554	479	17	4	5843	4	CACNA1E	1	181754552	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	48989	181754552	67496069	66	30394											
CACNA1E	777	broad.mit.edu	37	chr1	181759621	181759621	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttcgatgagtccactctctCcccaggatatattccagttg	8	13	7	13	1	1	1	0	1	1	0	6	3	4	2	4	1	0	1	4	1	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:181759621C>T	uc001gow.2	+	44	5992	c.5827C>T	c.(5827-5829)CCC>TCC	p.P1943S	CACNA1E_uc009wxs.2_Missense_Mutation_p.P1831S|CACNA1E_uc009wxt.2_Missense_Mutation_p.P1169S	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1943	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCCACTCTCTCCCCAGGATAT	0.498													9	35					0	0	0	0	T	181759621	T	T	181759621	3	4	166	1	0	0	0	0	1	0	0	0	2554	855	30	2	6001	2	CACNA1E	1	181759621	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5069	181759621	67491000	67	30395											
GLUL	2752	broad.mit.edu	37	chr1	182354693	182354693	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtccaatctgaaattcccacTagaaacgagaagcttggcca	14	8	8	11	1	1	3	0	1	1	2	3	4	3	3	3	1	2	1	3	1	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:182354693T>C	uc001gpa.1	-	6	816	c.604_splice	c.e6-1	p.W202_splice	GLUL_uc010pnt.1_5'UTR|GLUL_uc001gpb.1_Splice_Site_p.W202_splice|GLUL_uc001gpc.1_Splice_Site_p.W202_splice|GLUL_uc001gpd.1_Splice_Site_p.W202_splice	NM_001033056	NP_001028228	P15104	GLNA_HUMAN	glutamine synthetase						cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding				0					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	AAATTCCCACTAGAAACGAGA	0.463													19	51					0	0	0	0	C	182354693	C	C	182354693	5	2	166	1	0	0	0	0	0	0	1	0	6515	1536	53	5	527	5	GLUL	1	182354693	Splice_Site	SNP	T	TCGA-CR-7402-01A-11D-2012-08	595072	182354693	66895928	68	30396											
C1orf25	81627	broad.mit.edu	37	chr1	185114616	185114616	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctttattcatgtggcgccTaacatgtcctagcatatcag	9	14	7	11	1	2	0	2	0	0	0	4	0	4	0	3	1	2	1	3	1	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:185114616T>A	uc001grf.3	-	5	882	c.610A>T	c.(610-612)AGG>TGG	p.R204W	C1orf25_uc010pon.1_Missense_Mutation_p.R48W	NM_030934	NP_112196	Q7Z2T5	TRM1L_HUMAN	N2,N2-dimethylguanosine tRNA	204	C2H2-type.					intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding				0						ATGTGGCGCCTAACATGTCCT	0.343													20	61					0	0	0	0	A	185114616	A	A	185114616	3	1	166	1	0	0	0	0	1	0	0	0	2044	1521	53	5	1635	5	C1orf25	1	185114616	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2759923	185114616	64136005	69	30397											
FAM5C	339479	broad.mit.edu	37	chr1	190067933	190067933	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcatggacttctattcgtcTgtccgttttctgcagcagat	6	15	10	10	2	3	1	0	0	3	1	5	2	4	2	1	2	2	4	1	2	1	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:190067933T>A	uc001gse.1	-	8	1748	c.1516A>T	c.(1516-1518)AGA>TGA	p.R506*	FAM5C_uc010pot.1_Nonsense_Mutation_p.R404*	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	506						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TCTATTCGTCTGTCCGTTTTC	0.488													53	127					0	0	0	0	A	190067933	A	A	190067933	4	1	166	1	0	0	0	0	0	1	0	0	5626	1588	55	5	788	5	FAM5C	1	190067933	Nonsense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	4953317	190067933	59182688	70	30398											
PTPRC	5788	broad.mit.edu	37	chr1	198721748	198721748	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agactctcgaactgtgtaccAgtaccaatatacaaactgga	15	9	7	10	1	1	1	0	0	1	1	2	3	1	2	2	1	5	2	2	1	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:198721748A>T	uc001gur.1	+	31	3530	c.3350A>T	c.(3349-3351)CAG>CTG	p.Q1117L	PTPRC_uc001gus.1_Missense_Mutation_p.Q1069L|PTPRC_uc001gut.1_Missense_Mutation_p.Q956L	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1117	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ACTGTGTACCAGTACCAATAT	0.378													10	39					0	0	0	0	T	198721748	T	T	198721748	3	4	166	1	0	0	0	0	1	0	0	0	12862	188	7	5	3479	5	PTPRC	1	198721748	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	8653815	198721748	50528873	71	30399											
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200826433	200826433	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgttaaatccctaccataGgaccaaagctctacaaagaa	16	9	6	10	0	1	1	0	0	1	1	2	2	2	2	3	1	3	3	3	1	8	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:200826433G>C	uc001gvl.2	+	17	4316	c.4046_splice	c.e17-1	p.G1349_splice	CAMSAP1L1_uc001gvk.2_Splice_Site_p.G1338_splice|CAMSAP1L1_uc001gvm.2_Splice_Site_p.G1322_splice	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein							cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CCCTACCATAGGACCAAAGCT	0.323													10	25					0	0	0	0	C	200826433	C	C	200826433	5	2	166	1	0	0	0	0	0	0	1	0	2624	1014	35	4	4074	4	CAMSAP1L1	1	200826433	Splice_Site	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2104685	200826433	48424188	72	30400											
KIF21B	23046	broad.mit.edu	37	chr1	200948800	200948800	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtggccctttagagctgcGatctcctgtcccgtaaccaa	7	10	11	13	2	1	1	0	0	1	1	3	2	2	1	4	2	3	2	4	2	3	3	rs144601295		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:200948800G>T	uc001gvs.1	-	30	4340	c.4023C>A	c.(4021-4023)ATC>ATA	p.I1341I	KIF21B_uc001gvr.1_Silent_p.I1328I|KIF21B_uc009wzl.1_Silent_p.I1341I|KIF21B_uc010ppn.1_Silent_p.I1328I	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1341	WD 1.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TTAGAGCTGCGATCTCCTGTC	0.587											OREG0014066	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	166					4.49761e-31	1.11728e-30	1	0	T	200948800	T	T	200948800	2	4	166	1	0	0	0	0	0	0	0	1	8328	1048	37	3		3	KIF21B	1	200948800	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	122367	200948800	48301821	73	30401											
CHIT1	1118	broad.mit.edu	37	chr1	203192687	203192687	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggcttcctgggtactccCagtcaaggtcaaggccgtca	7	9	11	14	1	3	0	3	0	0	0	5	0	5	0	4	4	1	2	4	4	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:203192687C>A	uc001gzn.2	-	5	512	c.416G>T	c.(415-417)TGG>TTG	p.W139L	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_5'Flank|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.W130L	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	139					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						TGGGTACTCCCAGTCAAGGTC	0.582													42	83					9.85913e-13	2.00663e-12	1	0	A	203192687	A	A	203192687	3	1	166	1	0	0	0	0	1	0	0	0	3361	595	21	4	1012	4	CHIT1	1	203192687	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2243887	203192687	46057934	74	30402											
FCAMR	83953	broad.mit.edu	37	chr1	207131928	207131928	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagagagtcatcctggagcAtctttctttccacatggggc	9	11	11	10	0	3	1	1	0	2	1	5	4	5	2	2	3	1	1	2	3	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:207131928A>T	uc001hfa.3	-	8	2167	c.1667T>A	c.(1666-1668)ATG>AAG	p.M556K	FCAMR_uc001hfb.2_3'UTR|FCAMR_uc009xca.1_3'UTR|FCAMR_uc001hfc.2_Missense_Mutation_p.M531K	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	511	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						ATCCTGGAGCATCTTTCTTTC	0.537													28	62					0	0	0	0	T	207131928	T	T	207131928	3	4	166	1	0	0	0	0	1	0	0	0	5804	217	8	5	70	5	FCAMR	1	207131928	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	3939241	207131928	42118693	75	30403											
CR1	1378	broad.mit.edu	37	chr1	207790123	207790123	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttggagcagccctgcccctCgctgtgaactttctgttcct	4	14	9	14	1	1	1	0	1	1	0	3	2	2	2	4	1	4	3	4	1	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:207790123C>G	uc001hfy.2	+	33	5655	c.5515C>G	c.(5515-5517)CGC>GGC	p.R1839G	CR1_uc001hfx.2_Missense_Mutation_p.R2289G	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1839	Sushi 28.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						CCCTGCCCCTCGCTGTGAACT	0.507													37	114					0	0	0	0	G	207790123	G	G	207790123	3	3	166	1	0	0	0	0	1	0	0	0	3855	884	31	3	7027	3	CR1	1	207790123	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	658195	207790123	41460498	76	30404											
USH2A	7399	broad.mit.edu	37	chr1	215847664	215847664	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttccatccctgagggtgctGaggggctggttcgatctttg	4	13	15	9	1	1	2	0	2	1	0	4	3	3	2	2	4	1	4	2	4	0	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:215847664G>T	uc001hku.1	-	63	13976	c.13589C>A	c.(13588-13590)TCA>TAA	p.S4530*		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4530	Fibronectin type-III 31.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGAGGGTGCTGAGGGGCTGGT	0.512										HNSCC(13;0.011)			43	81					7.05121e-23	1.69783e-22	1	0	T	215847664	T	T	215847664	4	4	166	1	0	0	0	0	0	1	0	0	17104	1294	45	2	2059	2	USH2A	1	215847664	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	8057541	215847664	33402957	77	30405											
WDR26	80232	broad.mit.edu	37	chr1	224585902	224585902	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactttcttactaaaactctGtcttgcaagtcccataaatg	12	15	4	10	0	3	0	0	0	3	0	4	0	4	0	1	0	4	1	1	0	7	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:224585902G>C	uc001hop.3	-	12	1596	c.1230C>G	c.(1228-1230)GAC>GAG	p.D410E	WDR26_uc001hoq.3_Missense_Mutation_p.D394E|WDR26_uc010pvh.1_Missense_Mutation_p.D117E	NM_025160	NP_079436	Q9H7D7	WDR26_HUMAN	WD repeat domain 26 isoform a	557	WD 4.					cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)		CTAAAACTCTGTCTTGCAAGT	0.358													10	18					0	0	0	0	C	224585902	C	C	224585902	3	2	166	1	0	0	0	0	1	0	0	0	17351	1368	48	4	326	4	WDR26	1	224585902	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	8738238	224585902	24664719	78	30406											
OBSCN	84033	broad.mit.edu	37	chr1	228481186	228481186	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcatgagaccctcagagatgGagacagacacagcctgaggc	13	4	13	11	0	1	5	1	2	0	4	1	8	1	5	2	2	1	1	2	2	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:228481186G>T	uc009xez.1	+	41	11044	c.11000G>T	c.(10999-11001)GGA>GTA	p.G3667V	OBSCN_uc001hsn.2_Missense_Mutation_p.G3667V|OBSCN_uc001hsq.1_Missense_Mutation_p.G923V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3667	Ig-like 37.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTCAGAGATGGAGACAGACAC	0.642													25	50					4.87955e-14	1.02179e-13	1	0	T	228481186	T	T	228481186	3	4	166	1	0	0	0	0	1	0	0	0	10866	1174	41	2	11158	2	OBSCN	1	228481186	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3895284	228481186	20769435	79	30407											
TAF5L	27097	broad.mit.edu	37	chr1	229730582	229730582	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtacgtccgatcaaatgacCacagcctggcggtgcggtcg	8	7	14	12	5	1	1	1	1	0	0	3	2	2	1	3	4	3	1	3	4	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:229730582C>A	uc001htq.2	-	5	1398	c.1232G>T	c.(1231-1233)TGG>TTG	p.W411L		NM_014409	NP_055224	O75529	TAF5L_HUMAN	PCAF associated factor 65 beta isoform a	411	WD 3.				histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				ATCAAATGACCACAGCCTGGC	0.547													21	92					7.41877e-09	1.39013e-08	1	0	A	229730582	A	A	229730582	3	1	166	1	0	0	0	0	1	0	0	0	15595	595	21	4	541	4	TAF5L	1	229730582	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1249396	229730582	19520039	80	30408											
URB2	9816	broad.mit.edu	37	chr1	229794961	229794961	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcgctgcagccgggaatgAgagacatctttaaggagctc	10	8	12	11	2	1	2	0	1	1	1	3	5	1	4	2	2	3	3	2	2	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:229794961A>G	uc001hts.1	+	10	4628	c.4492A>G	c.(4492-4494)AGA>GGA	p.R1498G	URB2_uc009xfd.1_Missense_Mutation_p.R1498G	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1498						nucleolus				central_nervous_system(2)|ovary(1)	3						GCCGGGAATGAGAGACATCTT	0.507													43	140					0	0	0	0	G	229794961	G	G	229794961	3	3	166	1	0	0	0	0	1	0	0	0	17093	296	11	5	4526	5	URB2	1	229794961	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	64379	229794961	19455660	81	30409											
NID1	4811	broad.mit.edu	37	chr1	236208939	236208939	+	Frame_Shift_Del	DEL	G	-	-																															ggataaaggaaaatggcataGgagctggaatcagaggaggc																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:236208939delG	uc001hxo.2	-	3	672	c.570delC	c.(568-570)TCCfs	p.S190fs	NID1_uc009xgd.2_Frame_Shift_Del_p.S190fs	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	190	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	AAATGGCATAGGAGCTGGAAT	0.413													---	---	---								-	236208939	-	-	236208939	7	5	166	1	0	1	0	1	0	0	0	0	10468	987	35	0	3245	0	NID1	1	236208939	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	6413978	236208939	13041682	82	30410											
ACTN2	88	broad.mit.edu	37	chr1	236912520	236912520	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggatggagggcgctatggagGatctgcaagatatgttcatt	10	11	15	5	1	2	1	1	0	1	1	2	5	2	5	0	5	1	3	0	5	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:236912520G>C	uc001hyf.2	+	14	1816	c.1612G>C	c.(1612-1614)GAT>CAT	p.D538H	ACTN2_uc001hyg.2_Missense_Mutation_p.D330H|ACTN2_uc009xgi.1_Missense_Mutation_p.D538H|ACTN2_uc010pxu.1_Missense_Mutation_p.D227H|ACTN2_uc001hyh.2_Missense_Mutation_p.D226H	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	538	Spectrin 3.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGCTATGGAGGATCTGCAAGA	0.443													17	65					0	0	0	0	C	236912520	C	C	236912520	3	2	166	1	0	0	0	0	1	0	0	0	205	1174	41	2	1666	2	ACTN2	1	236912520	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	703581	236912520	12338101	83	30411											
RYR2	6262	broad.mit.edu	37	chr1	237608772	237608772	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagcatgaagaatcacgCacagcccgagttatccggag	12	6	10	13	3	1	2	1	1	0	1	3	4	3	3	3	1	2	3	3	1	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:237608772C>A	uc001hyl.1	+	14	1362	c.1242C>A	c.(1240-1242)CGC>CGA	p.R414R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	414	Cytoplasmic (By similarity).		R -> L (in CPVT1).		cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAGAATCACGCACAGCCCGAG	0.393													25	109					2.21704e-12	4.45681e-12	1	0	A	237608772	A	A	237608772	2	1	166	1	0	0	0	0	0	0	0	1	13834	697	25	4		4	RYR2	1	237608772	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	696252	237608772	11641849	84	30412											
RYR2	6262	broad.mit.edu	37	chr1	237947191	237947191	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccataagcactacacgcAgtcagaaacggaatttcttt	14	9	8	10	2	2	1	1	0	1	1	2	3	2	2	1	1	4	2	1	1	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:237947191A>C	uc001hyl.1	+	90	12299	c.12179A>C	c.(12178-12180)CAG>CCG	p.Q4060P	RYR2_uc010pya.1_Missense_Mutation_p.Q475P	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4060					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CACTACACGCAGTCAGAAACG	0.483													12	14					0	0	0	0	C	237947191	C	C	237947191	3	2	166	1	0	0	0	0	1	0	0	0	13834	188	7	5	12537	5	RYR2	1	237947191	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	338419	237947191	11303430	85	30413											
PLD5	200150	broad.mit.edu	37	chr1	242253370	242253370	+	Frame_Shift_Del	DEL	C	-	-																															ggttgataacaaggcccgtgCcagcattctgagtgaaatca																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:242253370delC	uc001hzn.1	-	10	1524	c.1397delG	c.(1396-1398)GGCfs	p.G466fs	PLD5_uc001hzl.3_Frame_Shift_Del_p.G404fs|PLD5_uc001hzm.3_Frame_Shift_Del_p.G256fs|PLD5_uc001hzo.1_Frame_Shift_Del_p.G374fs			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	466						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AAGGCCCGTGCCAGCATTCTG	0.423													---	---	---								-	242253370	-	-	242253370	7	5	166	1	0	1	0	1	0	0	0	0	12104	739	26	0	217	0	PLD5	1	242253370	Frame_Shift_Del	DEL	C	TCGA-CR-7402-01A-11D-2012-08	4306179	242253370	6997251	86	30414											
HNRNPU	3192	broad.mit.edu	37	chr1	245018845	245018845	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atagccgattccaccacttcCtccaccgccaccacctctct	8	9	3	21	2	1	0	0	0	1	0	5	1	4	0	9	0	1	0	9	0	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:245018845C>G	uc001iaz.1	-	12	2451	c.2233G>C	c.(2233-2235)GGA>CGA	p.G745R	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Missense_Mutation_p.G469R|HNRNPU_uc001iba.1_Missense_Mutation_p.G726R	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	745	Gly-rich.|Poly-Gly.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			CCACCACTTCCTCCACCGCCA	0.507													30	110					0	0	0	0	G	245018845	G	G	245018845	3	3	166	1	0	0	0	0	1	0	0	0	7312	690	24	4	256	4	HNRNPU	1	245018845	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2765475	245018845	4231776	87	30415											
AHCTF1	25909	broad.mit.edu	37	chr1	247013403	247013403	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacgttttctaggtatggCagacatatcaaattctgctt	11	14	7	9	1	3	1	1	0	2	1	3	1	3	1	1	2	1	4	1	2	4	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247013403C>A	uc001ibu.1	-	32	5912	c.5905G>T	c.(5905-5907)GCC>TCC	p.A1969S	AHCTF1_uc001ibv.1_Missense_Mutation_p.A1978S|AHCTF1_uc009xgs.1_Missense_Mutation_p.A830S|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1969	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTAGGTATGGCAGACATATCA	0.428													32	126					8.16721e-17	1.817e-16	1	0	A	247013403	A	A	247013403	3	1	166	1	0	0	0	0	1	0	0	0	408	710	25	4	911	4	AHCTF1	1	247013403	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1994558	247013403	2237218	88	30416											
OR2C3	81472	broad.mit.edu	37	chr1	247695520	247695520	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatatagaactggaccacAcaccctccatagcttatggt	13	9	8	11	0	0	2	0	0	0	2	1	4	1	3	3	2	2	1	3	2	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247695520A>T	uc009xgy.2	-	2	656	c.294T>A	c.(292-294)TGT>TGA	p.C98*	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			ACTGGACCACACACCCTCCAT	0.577													18	51					0	0	0	0	T	247695520	T	T	247695520	4	4	166	1	0	0	0	0	0	1	0	0	11047	157	6	5	672	5	OR2C3	1	247695520	Nonsense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	682117	247695520	1555101	89	30417											
OR2G3	81469	broad.mit.edu	37	chr1	247769112	247769112	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggacatctgcttcactacTagccttgctcctcagacctt	7	13	6	15	0	3	1	2	0	1	1	4	2	4	2	3	1	4	2	3	1	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247769112T>C	uc010pyz.1	+	1	225	c.225T>C	c.(223-225)ACT>ACC	p.T75T		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCTTCACTACTAGCCTTGCTC	0.448													178	207					0	0	0	0	C	247769112	C	C	247769112	2	2	166	1	0	0	0	0	0	0	0	1	11053	1509	53	5		5	OR2G3	1	247769112	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	73592	247769112	1481509	90	30418											
OR13G1	441933	broad.mit.edu	37	chr1	247835616	247835616	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatagtaaagggtcaccactGtgagatgagatgagcatgtt	14	10	12	5	0	1	3	1	3	0	2	1	5	1	3	1	1	1	3	1	1	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247835616G>T	uc001idi.1	-	1	728	c.728C>A	c.(727-729)ACA>AAA	p.T243K		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GGTCACCACTGTGAGATGAGA	0.448													44	42					1.41504e-22	3.3947e-22	1	0	T	247835616	T	T	247835616	3	4	166	1	0	0	0	0	1	0	0	0	10996	1377	48	4	199	4	OR13G1	1	247835616	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	66504	247835616	1415005	91	30419											
OR14A16	284532	broad.mit.edu	37	chr1	247978277	247978277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcttcagataagcaatgaatCcagtggaaagaaataacaca	19	7	8	7	0	1	3	1	1	0	2	2	4	2	4	1	1	2	2	1	1	6	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247978277C>T	uc001idm.1	-	1	755	c.755G>A	c.(754-756)GGA>GAA	p.G252E		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCAATGAATCCAGTGGAAAG	0.433													18	22					0	0	0	0	T	247978277	T	T	247978277	3	4	166	1	0	0	0	0	1	0	0	0	10999	855	30	2	178	2	OR14A16	1	247978277	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	142661	247978277	1272344	92	30420											
OR2T8	343172	broad.mit.edu	37	chr1	248084536	248084536	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatggacgtgatgctggttTccaccactgtgcccaaaatg	9	11	10	11	1	1	1	1	1	0	0	2	2	2	2	3	2	2	2	3	2	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248084536T>C	uc010pzc.1	+	1	217	c.217T>C	c.(217-219)TCC>CCC	p.S73P		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GATGCTGGTTTCCACCACTGT	0.572													6	129					0	0	0	0	C	248084536	C	C	248084536	3	2	166	1	0	0	0	0	1	0	0	0	11084	1783	62	5	219	5	OR2T8	1	248084536	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	106259	248084536	1166085	93	30421											
OR2AK2	391191	broad.mit.edu	37	chr1	248129117	248129117	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgctgcctcatggttgcaTgtgcatgggccagtggttct	4	14	13	10	0	3	0	1	0	2	0	3	0	3	0	2	3	4	5	2	3	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248129117T>A	uc010pzd.1	+	1	484	c.484T>A	c.(484-486)TGT>AGT	p.C162S	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	162	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CATGGTTGCATGTGCATGGGC	0.413													111	148					0	0	0	0	A	248129117	A	A	248129117	3	1	166	1	0	0	0	0	1	0	0	0	11040	1464	51	5	486	5	OR2AK2	1	248129117	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	44581	248129117	1121504	94	30422											
OR2M5	127059	broad.mit.edu	37	chr1	248309365	248309365	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcactcaggaaagtgttaGgaaagggcaagtgtggagag	14	6	17	4	0	1	1	1	0	0	1	1	5	1	3	0	4	1	3	0	4	4	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248309365G>T	uc010pze.1	+	1	916	c.916G>T	c.(916-918)GGA>TGA	p.G306*		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GAAAGTGTTAGGAAAGGGCAA	0.443													38	52					1.57351e-24	3.82167e-24	1	0	T	248309365	T	T	248309365	4	4	166	1	0	0	0	0	0	1	0	0	11067	1001	35	4	918	4	OR2M5	1	248309365	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	180248	248309365	941256	95	30423											
OR2M3	127062	broad.mit.edu	37	chr1	248366631	248366631	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggccttcaactacctgtctGgcagcaagtccatttctatg	8	13	8	12	0	3	0	1	0	2	0	4	0	4	0	3	2	3	2	3	2	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248366631G>T	uc010pzg.1	+	1	262	c.262G>T	c.(262-264)GGC>TGC	p.G88C		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTACCTGTCTGGCAGCAAGTC	0.502													135	417					1.41203e-78	3.62248e-78	1	0	T	248366631	T	T	248366631	3	4	166	1	0	0	0	0	1	0	0	0	11065	1348	47	4	264	4	OR2M3	1	248366631	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	57266	248366631	883990	96	30424											
OR2M3	127062	broad.mit.edu	37	chr1	248366998	248366998	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatagtaatgattgttttccCtgttgcaatcatcattgctt	9	19	6	7	0	2	1	2	1	0	0	3	1	3	1	1	0	2	5	1	0	4	9			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248366998C>A	uc010pzg.1	+	1	629	c.629C>A	c.(628-630)CCT>CAT	p.P210H		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATTGTTTTCCCTGTTGCAATC	0.418													168	236					5.60145e-70	1.43514e-69	1	0	A	248366998	A	A	248366998	3	1	166	1	0	0	0	0	1	0	0	0	11065	681	24	4	631	4	OR2M3	1	248366998	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	367	248366998	883623	97	30425											
OR2T34	127068	broad.mit.edu	37	chr1	248737333	248737333	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggaggagcaggtggccaaGgccttcctgcggccggcggc	5	5	19	12	3	0	0	0	0	0	0	1	2	1	2	4	8	2	1	4	8	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248737333G>A	uc001iep.1	-	1	726	c.726C>T	c.(724-726)GCC>GCT	p.A242A		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGTGGCCAAGGCCTTCCTGC	0.567													112	127					0	0	0	0	A	248737333	A	A	248737333	2	1	166	1	0	0	0	0	0	0	0	1	11079	987	35	4		4	OR2T34	1	248737333	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	370335	248737333	513288	98	30426											
OR2T11	127077	broad.mit.edu	37	chr1	248790227	248790227	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagtggtacagatgaaaaggGtgtccatgatggacagctga	13	8	14	6	0	0	4	0	3	0	1	1	5	1	5	1	3	2	2	1	3	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248790227G>C	uc001ier.1	-	1	203	c.203C>G	c.(202-204)ACC>AGC	p.T68S		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATGAAAAGGGTGTCCATGAT	0.483													41	57					0	0	0	0	C	248790227	C	C	248790227	3	2	166	1	0	0	0	0	1	0	0	0	11072	1261	44	4	751	4	OR2T11	1	248790227	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	52894	248790227	460394	99	30427											
TPO	7173	broad.mit.edu	37	chr2	1480964	1480964	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcgctctttgggaacctgtCcacggccaacccgcggcagc	6	6	12	17	5	1	0	0	0	1	0	2	1	2	1	4	3	3	2	4	3	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1480964C>A	uc002qww.2	+	8	1017	c.926C>A	c.(925-927)TCC>TAC	p.S309Y	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.S309Y|TPO_uc002qwr.2_Missense_Mutation_p.S309Y|TPO_uc002qwx.2_Missense_Mutation_p.S309Y|TPO_uc010yio.1_Intron|TPO_uc010yip.1_Missense_Mutation_p.S309Y	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	309	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGAACCTGTCCACGGCCAAC	0.706													9	25					7.48243e-07	1.3381e-06	1	0	A	1480964	A	A	1480964	3	1	166	1	0	0	0	0	1	0	0	0	16477	855	30	2	952	2	TPO	2	1480964	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08		1480964	241718409	100	30428											
PXDN	7837	broad.mit.edu	37	chr2	1658260	1658260	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtagctacaaacggatctcCatttcgactgacgtcaggaa	12	9	10	10	3	2	1	1	1	1	0	4	4	2	3	1	3	3	2	1	3	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1658260C>A	uc002qxa.2	-	15	1922	c.1858G>T	c.(1858-1860)GGA>TGA	p.G620*	PXDN_uc002qxb.1_Nonsense_Mutation_p.G620*	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	620					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AACGGATCTCCATTTCGACTG	0.428													15	32					7.93312e-07	1.41354e-06	1	0	A	1658260	A	A	1658260	4	1	166	1	0	0	0	0	0	1	0	0	12912	603	21	4	2617	4	PXDN	2	1658260	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	177296	1658260	241541113	101	30429											
PXDN	7837	broad.mit.edu	37	chr2	1680770	1680770	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaagtacacggtgttcccCgaggtcacatctgcgtcctg	7	10	12	12	3	2	1	1	1	1	0	4	2	4	1	3	2	2	2	3	2	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1680770C>T	uc002qxa.2	-	8	841	c.777G>A	c.(775-777)TCG>TCA	p.S259S	PXDN_uc002qxb.1_Silent_p.S259S|PXDN_uc002qxc.1_Silent_p.S76S	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	259	Ig-like C2-type 1.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CGGTGTTCCCCGAGGTCACAT	0.532													6	14					0	0	0	0	T	1680770	T	T	1680770	2	4	166	1	0	0	0	0	0	0	0	1	12912	639	23	1		1	PXDN	2	1680770	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	22510	1680770	241518603	102	30430											
MYT1L	23040	broad.mit.edu	37	chr2	1890319	1890319	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attaaatcttacttgagttcTtgggagctggtggccagcat	9	14	11	7	0	2	1	0	1	2	0	2	2	2	2	1	3	3	3	1	3	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1890319T>A	uc002qxe.2	-	18	3530	c.2703A>T	c.(2701-2703)CAA>CAT	p.Q901H	MYT1L_uc002qxd.2_Missense_Mutation_p.Q899H|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	901					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ACTTGAGTTCTTGGGAGCTGG	0.433													18	42					0	0	0	0	A	1890319	A	A	1890319	3	1	166	1	0	0	0	0	1	0	0	0	10160	1606	56	5	889	5	MYT1L	2	1890319	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	209549	1890319	241309054	103	30431											
MYT1L	23040	broad.mit.edu	37	chr2	1914014	1914014	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcactcctgctgggtacctGagcacgcggtccgaggcctg	5	8	14	14	3	0	1	0	1	0	0	2	2	2	1	4	3	4	4	4	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1914014G>A	uc002qxe.2	-	13	2642	c.1815C>T	c.(1813-1815)CTC>CTT	p.L605L	MYT1L_uc002qxd.2_Silent_p.L603L|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	605					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTGGGTACCTGAGCACGCGGT	0.637													5	37					0	0	0	0	A	1914014	A	A	1914014	2	1	166	1	0	0	0	0	0	0	0	1	10160	1277	45	2		2	MYT1L	2	1914014	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	23695	1914014	241285359	104	30432											
ADAM17	6868	broad.mit.edu	37	chr2	9666299	9666299	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtatctgtagaagcgatgatCtgctaccaccaataatttac	13	12	7	9	1	2	2	0	1	2	1	2	3	2	2	2	0	4	3	2	0	7	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:9666299C>G	uc002qzu.2	-	6	877	c.694G>C	c.(694-696)GAT>CAT	p.D232H	ADAM17_uc010ewy.2_Missense_Mutation_p.D232H|ADAM17_uc010ewz.2_Intron|ADAM17_uc010exa.2_5'Flank|ADAM17_uc010exb.1_3'UTR	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	232	Peptidase M12B.|Extracellular (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		AAGCGATGATCTGCTACCACC	0.358													35	92					0	0	0	0	G	9666299	G	G	9666299	3	3	166	1	0	0	0	0	1	0	0	0	238	913	32	2	1836	2	ADAM17	2	9666299	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	7752285	9666299	233533074	105	30433											
GREB1	9687	broad.mit.edu	37	chr2	11702672	11702672	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccccccaaaccctttccagCtgcaccctctgcctgaagga	8	7	7	19	0	1	1	0	1	1	0	2	2	2	2	7	1	4	2	7	1	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:11702672C>G	uc002rbk.1	+	3	541	c.241C>G	c.(241-243)CTG>GTG	p.L81V	GREB1_uc002rbl.2_Missense_Mutation_p.L81V|GREB1_uc002rbm.2_5'UTR|GREB1_uc002rbn.1_Missense_Mutation_p.L81V	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	81						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CCCTTTCCAGCTGCACCCTCT	0.612													29	87					0	0	0	0	G	11702672	G	G	11702672	3	3	166	1	0	0	0	0	1	0	0	0	6799	796	28	4	247	4	GREB1	2	11702672	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2036373	11702672	231496701	106	30434											
NBAS	51594	broad.mit.edu	37	chr2	15470842	15470842	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcatggtggtagcagtggtCcagcgcaataggtcagctga	9	10	14	8	1	2	1	2	1	0	0	3	1	3	1	1	4	3	4	1	4	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:15470842C>A	uc002rcc.1	-	36	4253	c.4227G>T	c.(4225-4227)TGG>TGT	p.W1409C	NBAS_uc010exl.1_Missense_Mutation_p.W481C|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1409										ovary(2)|liver(1)|skin(1)	4						TAGCAGTGGTCCAGCGCAATA	0.468													19	57					2.4624e-09	4.68573e-09	1	0	A	15470842	A	A	15470842	3	1	166	1	0	0	0	0	1	0	0	0	10239	856	30	2	2956	2	NBAS	2	15470842	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3768170	15470842	227728531	107	30435											
APOB	338	broad.mit.edu	37	chr2	21230042	21230042	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtgagatttttcagctttgTacttatcaaacttaattttt	10	20	5	6	1	2	1	2	1	0	1	2	2	2	1	0	0	3	2	0	0	4	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:21230042T>C	uc002red.2	-	26	9826	c.9698A>G	c.(9697-9699)TAC>TGC	p.Y3233C		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3233	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCAGCTTTGTACTTATCAAA	0.363													19	27					0	0	0	0	C	21230042	C	C	21230042	3	2	166	1	0	0	0	0	1	0	0	0	785	1638	57	5	4009	5	APOB	2	21230042	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5759200	21230042	221969331	108	30436											
APOB	338	broad.mit.edu	37	chr2	21235485	21235485	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacccatcatatgatagtgTgaacgtattcttgtggtcat	11	14	9	7	1	3	3	2	2	1	1	3	3	3	3	1	1	1	1	1	1	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:21235485T>A	uc002red.2	-	26	4383	c.4255A>T	c.(4255-4257)ACA>TCA	p.T1419S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1419					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity	p.T1419A(1)		ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TATGATAGTGTGAACGTATTC	0.343													9	45					0	0	0	0	A	21235485	A	A	21235485	3	1	166	1	0	0	0	0	1	0	0	0	785	1696	59	5	9452	5	APOB	2	21235485	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5443	21235485	221963888	109	30437											
C2orf53	339779	broad.mit.edu	37	chr2	27360306	27360306	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgaggcaggcggaggccgaAgccgatgcctatccggagtg	8	5	17	11	4	0	1	0	1	0	0	1	5	1	3	4	5	2	1	4	5	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:27360306A>T	uc002rjb.2	-	3	1472	c.892T>A	c.(892-894)TTC>ATC	p.F298I	PREB_uc002rix.1_5'Flank|PREB_uc002riy.1_5'Flank|PREB_uc002riz.1_5'Flank|PREB_uc002rja.1_5'Flank	NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	298											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGGAGGCCGAAGCCGATGCCT	0.657													15	36					0	0	0	0	T	27360306	T	T	27360306	3	4	166	1	0	0	0	0	1	0	0	0	2184	72	3	5	350	5	C2orf53	2	27360306	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	6124821	27360306	215839067	110	30438											
TRMT61B	55006	broad.mit.edu	37	chr2	29092590	29092590	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcttgccgaacgggactgccCcccagttactatttaagagt	9	11	9	12	2	1	1	0	0	1	1	1	3	1	2	4	1	4	1	4	1	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:29092590C>A	uc002rmm.2	-	1	586	c.554G>T	c.(553-555)GGG>GTG	p.G185V	TRMT61B_uc002rmn.2_Missense_Mutation_p.G185V|TRMT61B_uc010ezk.2_RNA	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	185							tRNA (adenine-N1-)-methyltransferase activity				0						CGGGACTGCCCCCCAGTTACT	0.498													33	91					2.68265e-12	5.38178e-12	1	0	A	29092590	A	A	29092590	3	1	166	1	0	0	0	0	1	0	0	0	16637	623	22	4	907	4	TRMT61B	2	29092590	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1732284	29092590	214106783	111	30439											
WDR43	23160	broad.mit.edu	37	chr2	29158393	29158393	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttattttctcacagaaagtaCttcaaactaggaatgtaaac	16	13	5	7	0	2	1	2	0	1	1	3	2	2	2	0	1	3	2	0	1	8	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:29158393C>T	uc002rmo.2	+	12	1476	c.1444C>T	c.(1444-1446)CTT>TTT	p.L482F		NM_015131	NP_055946	Q15061	WDR43_HUMAN	WD repeat domain 43	482						nucleolus				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					ACAGAAAGTACTTCAAACTAG	0.318													10	39					0	0	0	0	T	29158393	T	T	29158393	3	4	166	1	0	0	0	0	1	0	0	0	17363	565	20	4	1490	4	WDR43	2	29158393	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	65803	29158393	214040980	112	30440											
CAPN13	92291	broad.mit.edu	37	chr2	30959385	30959385	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacctggtagtgaacaaggCgcttccacagtcgcgcaaac	11	7	11	12	3	0	1	0	1	0	0	2	1	1	1	2	2	3	4	2	2	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:30959385C>G	uc002rnn.2	-	17	1882	c.1706G>C	c.(1705-1707)CGC>CCC	p.R569P	CAPN13_uc002rnm.2_RNA	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	569	EF-hand 1.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GTGAACAAGGCGCTTCCACAG	0.408													23	46					0	0	0	0	G	30959385	G	G	30959385	3	3	166	1	0	0	0	0	1	0	0	0	2638	768	27	3	323	3	CAPN13	2	30959385	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1800992	30959385	212239988	113	30441											
NLRC4	58484	broad.mit.edu	37	chr2	32474682	32474682	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatttacaatacccggcaGccgttgattctgtaggtcat	10	13	9	9	2	2	1	1	1	1	0	2	2	2	1	2	2	3	3	2	2	5	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:32474682G>A	uc002roi.2	-	4	2497	c.2251C>T	c.(2251-2253)CTG>TTG	p.L751L	NLRC4_uc002roj.1_Silent_p.L751L|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	751	LRR 5.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					ATACCCGGCAGCCGTTGATTC	0.318													69	184					0	0	0	0	A	32474682	A	A	32474682	2	1	166	1	0	0	0	0	0	0	0	1	10523	962	34	4		4	NLRC4	2	32474682	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1515297	32474682	210724691	114	30442											
NLRC4	58484	broad.mit.edu	37	chr2	32475967	32475967	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggatttctgaatttggagCaacaagccttcagcaagctc	11	11	9	10	0	2	1	1	1	1	0	3	3	2	3	1	2	5	3	1	2	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:32475967C>T	uc002roi.2	-	4	1212	c.966G>A	c.(964-966)TTG>TTA	p.L322L	NLRC4_uc002roj.1_Silent_p.L322L|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	322	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GAATTTGGAGCAACAAGCCTT	0.507													18	51					0	0	0	0	T	32475967	T	T	32475967	2	4	166	1	0	0	0	0	0	0	0	1	10523	709	25	4		4	NLRC4	2	32475967	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1285	32475967	210723406	115	30443											
LTBP1	4052	broad.mit.edu	37	chr2	33540329	33540329	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctctgcagatggccgtacGtgtgaaggtaagataaacca	13	9	11	8	2	1	3	0	1	1	2	2	3	1	3	2	2	3	3	2	2	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:33540329G>A	uc002ros.2	+	24	3726	c.3726G>A	c.(3724-3726)ACG>ACA	p.T1242T	LTBP1_uc002rot.2_Silent_p.T916T|LTBP1_uc002rou.2_Silent_p.T915T|LTBP1_uc002rov.2_Silent_p.T862T|LTBP1_uc010ymz.1_Silent_p.T915T|LTBP1_uc010yna.1_Silent_p.T862T|LTBP1_uc010ynb.1_Silent_p.T181T	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1241	EGF-like 12; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ATGGCCGTACGTGTGAAGGTA	0.448													13	31					0	0	0	0	A	33540329	A	A	33540329	2	1	166	1	0	0	0	0	0	0	0	1	9123	1132	40	1		1	LTBP1	2	33540329	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1064362	33540329	209659044	116	30444											
RASGRP3	25780	broad.mit.edu	37	chr2	33741637	33741637	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagagctggataatagttaTttgccaagaatagttctact	13	13	10	5	0	1	2	0	0	1	2	1	4	1	3	1	2	3	3	1	2	7	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:33741637T>C	uc002rox.2	+	5	726	c.99T>C	c.(97-99)TAT>TAC	p.Y33Y	RASGRP3_uc010ync.1_Silent_p.Y33Y|RASGRP3_uc002roy.2_Silent_p.Y33Y	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	33	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					ATAATAGTTATTTGCCAAGAA	0.328													2	9					0	0	0	0	C	33741637	C	C	33741637	2	2	166	1	0	0	0	0	0	0	0	1	13141	1500	52	5		5	RASGRP3	2	33741637	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	201308	33741637	209457736	117	30445											
SLC8A1	6546	broad.mit.edu	37	chr2	40656936	40656936	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggaccgaggtctcctgcaGtgaagttatggccacacact	10	9	11	11	1	1	1	0	1	1	0	2	3	1	2	3	3	1	2	3	3	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:40656936G>T	uc002rrx.2	-	1	509	c.485C>A	c.(484-486)ACT>AAT	p.T162N	SLC8A1_uc002rry.2_Missense_Mutation_p.T162N|SLC8A1_uc002rrz.2_Missense_Mutation_p.T162N|SLC8A1_uc002rsa.2_Missense_Mutation_p.T162N|SLC8A1_uc002rsd.3_Missense_Mutation_p.T162N|SLC8A1_uc002rsb.1_Missense_Mutation_p.T162N|SLC8A1_uc010fan.1_Missense_Mutation_p.T162N|SLC8A1_uc002rsc.1_Missense_Mutation_p.T162N	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	162	Extracellular (Potential).|Alpha-1.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GTCTCCTGCAGTGAAGTTATG	0.468													20	57					1.56452e-12	3.16131e-12	1	0	T	40656936	T	T	40656936	3	4	166	1	0	0	0	0	1	0	0	0	14770	1029	36	4	2584	4	SLC8A1	2	40656936	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	6915299	40656936	202542437	118	30446											
NRXN1	9378	broad.mit.edu	37	chr2	50779852	50779852	+	Silent	SNP	C	T	T																															tagaggtggccatctagcatCtcaatagcaaagaagtccac																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:50779852C>T	uc010fbq.2	-	9	3229	c.1752G>A	c.(1750-1752)GAG>GAA	p.E584E	NRXN1_uc002rxb.3_Silent_p.E216E|NRXN1_uc002rxe.3_Silent_p.E544E|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CATCTAGCATCTCAATAGCAA	0.448													30	73					0	0	0	0	T	50779852	T	T	50779852	2	4	166	1	0	0	0	0	0	0	0	1	10719	912	32	2		2	NRXN1	2	50779852	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	10122916	50779852	192419521	119	30447	60	2									
NRXN1	9378	broad.mit.edu	37	chr2	50779857	50779857	+	Missense_Mutation	SNP	T	C	C																															gtggccatctagcatctcaaTagcaaagaagtccaccttta																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:50779857T>C	uc010fbq.2	-	9	3224	c.1747A>G	c.(1747-1749)ATT>GTT	p.I583V	NRXN1_uc002rxb.3_Missense_Mutation_p.I215V|NRXN1_uc002rxe.3_Missense_Mutation_p.I543V|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AGCATCTCAATAGCAAAGAAG	0.443													27	79					0	0	0	0	C	50779857	C	C	50779857	3	2	166	1	0	0	0	0	1	0	0	0	10719	1406	49	5	3219	5	NRXN1	2	50779857	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5	50779857	192419516	120	30448	60	2									
NRXN1	9378	broad.mit.edu	37	chr2	51254661	51254661	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggctgcagtccttgccgcGgaagccggttcgcgagcagt	5	9	15	12	5	0	0	0	0	0	0	2	2	1	1	3	3	4	4	3	3	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:51254661G>T	uc010fbq.2	-	2	2228	c.751C>A	c.(751-753)CGC>AGC	p.R251S	NRXN1_uc002rxe.3_Missense_Mutation_p.R251S|NRXN1_uc002rxd.1_Missense_Mutation_p.R251S	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TCCTTGCCGCGGAAGCCGGTT	0.751													5	30					0.000602214	0.00099105	1	0	T	51254661	T	T	51254661	3	4	166	1	0	0	0	0	1	0	0	0	10719	1116	39	3	4247	3	NRXN1	2	51254661	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	474804	51254661	191944712	121	30449											
NRXN1	9378	broad.mit.edu	37	chr2	51254722	51254722	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accacggagcacacacctccGttgaggcacaccccgccctc	9	4	8	20	3	0	1	0	1	0	0	2	2	1	2	6	2	1	3	6	2	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:51254722G>T	uc010fbq.2	-	2	2167	c.690C>A	c.(688-690)AAC>AAA	p.N230K	NRXN1_uc002rxe.3_Missense_Mutation_p.N230K|NRXN1_uc002rxd.1_Missense_Mutation_p.N230K	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACACACCTCCGTTGAGGCACA	0.711													11	15					4.68919e-08	8.62987e-08	1	0	T	51254722	T	T	51254722	3	4	166	1	0	0	0	0	1	0	0	0	10719	1136	40	3	4308	3	NRXN1	2	51254722	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	61	51254722	191944651	122	30450											
CCDC104	112942	broad.mit.edu	37	chr2	55756024	55756024	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttccacaggccattttgcAacctgtgttggcagcagaag	9	11	10	11	0	0	1	0	0	0	1	1	1	1	1	3	2	3	4	3	2	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:55756024A>T	uc002ryy.2	+	4	491	c.293A>T	c.(292-294)CAA>CTA	p.Q98L	CCDC104_uc002ryx.2_Missense_Mutation_p.Q123L	NM_080667	NP_542398	Q96G28	CC104_HUMAN	coiled-coil domain containing 104	98										ovary(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCCATTTTGCAACCTGTGTTG	0.363													5	34					0	0	0	0	T	55756024	T	T	55756024	3	4	166	1	0	0	0	0	1	0	0	0	2751	130	5	5	307	5	CCDC104	2	55756024	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	4501302	55756024	187443349	123	30451											
OTX1	5013	broad.mit.edu	37	chr2	63283445	63283446	+	Frame_Shift_Ins	INS	-	T	T																															cctcatggcggttccaggtcINSttgtgagcccaggaatgaaa																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:63283445_63283446insT	uc002scd.2	+	5	1307_1308	c.1059_1060insT	c.(1057-1062)GTCTTGfs	p.V353fs	OTX1_uc010ypt.1_Frame_Shift_Ins_p.V287fs	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	353_354						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					GGTTCCAGGTCTTGTGAGCCCA	0.604													---	---	---								T	63283446	T	T	63283445	7	5	166	1	0	1	1	0	0	0	0	0	11374	900	32	0	1069	0	OTX1	2	63283445	Frame_Shift_Ins	INS	-	TCGA-CR-7402-01A-11D-2012-08	7527421	63283445	179915928	124	30452											
MEIS1	4211	broad.mit.edu	37	chr2	66664968	66664968	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccatgcagccggtccacCacctgaaccacgggcctcct	7	6	10	18	2	0	1	0	1	0	0	3	1	3	1	8	3	3	1	8	3	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:66664968C>T	uc002sdu.2	+	2	569	c.112C>T	c.(112-114)CAC>TAC	p.H38Y	MEIS1_uc002sdt.2_Missense_Mutation_p.H38Y|MEIS1_uc002sdv.2_Missense_Mutation_p.H36Y|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_5'Flank|MEIS1_uc002sdw.1_5'Flank	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	38							sequence-specific DNA binding transcription factor activity				0						GCCGGTCCACCACCTGAACCA	0.612													7	25					0	0	0	0	T	66664968	T	T	66664968	3	4	166	1	0	0	0	0	1	0	0	0	9520	594	21	4	118	4	MEIS1	2	66664968	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3381523	66664968	176534405	125	30453											
ANXA4	307	broad.mit.edu	37	chr2	70015233	70015233	+	Frame_Shift_Del	DEL	G	-	-																															gcttcaggattcaatgccatGgaagatgcccagaccctgag																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:70015233delG	uc002sfr.3	+	3	284	c.57delG	c.(55-57)ATGfs	p.M19fs	ANXA4_uc010yqn.1_RNA|ANXA4_uc002sfs.3_Frame_Shift_Del_p.M19fs|ANXA4_uc010yqo.1_Intron	NM_001153	NP_001144	P09525	ANXA4_HUMAN	annexin IV	17					anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity				0						TCAATGCCATGGAAGATGCCC	0.532													---	---	---								-	70015233	-	-	70015233	7	5	166	1	0	1	0	1	0	0	0	0	720	1348	47	0	63	0	ANXA4	2	70015233	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	3350265	70015233	173184140	126	30454											
DYSF	8291	broad.mit.edu	37	chr2	71797809	71797809	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagatgtactacacacacCgacggcggcgctgggtgcgc	10	5	14	12	5	0	2	0	0	0	2	0	3	0	2	1	3	3	2	1	3	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:71797809C>T	uc002sie.2	+	29	3488	c.3112C>T	c.(3112-3114)CGA>TGA	p.R1038*	DYSF_uc010feg.2_Nonsense_Mutation_p.R1069*|DYSF_uc010feh.2_Nonsense_Mutation_p.R1024*|DYSF_uc002sig.3_Nonsense_Mutation_p.R1024*|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Nonsense_Mutation_p.R1038*|DYSF_uc010fef.2_Nonsense_Mutation_p.R1055*|DYSF_uc010fei.2_Nonsense_Mutation_p.R1055*|DYSF_uc010fek.2_Nonsense_Mutation_p.R1056*|DYSF_uc010fej.2_Nonsense_Mutation_p.R1025*|DYSF_uc010fel.2_Nonsense_Mutation_p.R1025*|DYSF_uc010feo.2_Nonsense_Mutation_p.R1070*|DYSF_uc010fem.2_Nonsense_Mutation_p.R1039*|DYSF_uc010fen.2_Nonsense_Mutation_p.R1056*|DYSF_uc002sif.2_Nonsense_Mutation_p.R1039*	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1038	Cytoplasmic (Potential).|Arg-rich.		R -> Q (in LGMD2B; uncertain pathogenicity).			cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CTACACACACCGACGGCGGCG	0.642													14	32					0	0	0	0	T	71797809	T	T	71797809	4	4	166	1	0	0	0	0	0	1	0	0	4881	644	23	1	3418	1	DYSF	2	71797809	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1782576	71797809	171401564	127	30455											
RAB11FIP5	26056	broad.mit.edu	37	chr2	73315415	73315415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttctctgccacagcctcaGaggaggccactatgggtgtg	7	9	12	13	0	2	1	1	0	1	1	3	2	2	2	4	3	2	0	4	3	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:73315415G>A	uc002siu.3	-	3	1572	c.1331C>T	c.(1330-1332)TCT>TTT	p.S444F	RAB11FIP5_uc002sit.3_Missense_Mutation_p.S366F	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	444					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CACAGCCTCAGAGGAGGCCAC	0.657													39	88					0	0	0	0	A	73315415	A	A	73315415	3	1	166	1	0	0	0	0	1	0	0	0	12962	942	33	2	642	2	RAB11FIP5	2	73315415	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1517606	73315415	169883958	128	30456											
RAB11FIP5	26056	broad.mit.edu	37	chr2	73315801	73315801	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagggcccgaggaggagcCactcgcatctggttggcctc	8	6	15	12	2	1	1	0	0	1	1	3	4	1	3	3	5	1	2	3	5	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:73315801C>G	uc002siu.3	-	3	1186	c.945G>C	c.(943-945)GTG>GTC	p.V315V	RAB11FIP5_uc002sit.3_Silent_p.V237V	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	315					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GAGGAGGAGCCACTCGCATCT	0.592													6	23					0	0	0	0	G	73315801	G	G	73315801	2	3	166	1	0	0	0	0	0	0	0	1	12962	581	21	4		4	RAB11FIP5	2	73315801	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	386	73315801	169883572	129	30457											
CCDC142	84865	broad.mit.edu	37	chr2	74709692	74709692	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agccgcagcaacaccgcccgGagacgctgcagcgcgggagg	9	1	16	15	6	0	1	0	0	0	1	0	3	0	2	3	3	5	4	3	3	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:74709692G>A	uc002slr.2	-	1	666	c.273C>T	c.(271-273)CTC>CTT	p.L91L	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Silent_p.L91L|CCDC142_uc002slp.2_Silent_p.L91L	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	91	Potential.									central_nervous_system(1)	1						ACACCGCCCGGAGACGCTGCA	0.716													7	8					0	0	0	0	A	74709692	A	A	74709692	2	1	166	1	0	0	0	0	0	0	0	1	2788	1161	41	2		2	CCDC142	2	74709692	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1393891	74709692	168489681	130	30458											
AUP1	550	broad.mit.edu	37	chr2	74754875	74754875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccacatacctgactgggggcGcaatctggggtgtctttgtc	6	11	13	11	1	2	1	0	1	2	0	3	1	2	1	2	4	1	1	2	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:74754875G>A	uc010yrx.1	-	7	1126	c.1000C>T	c.(1000-1002)CGC>TGC	p.R334C	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_Missense_Mutation_p.R10C|AUP1_uc002smf.2_Missense_Mutation_p.R277C|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Missense_Mutation_p.R186C|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ57204, highly similar to Homo sapiens ancient ubiquitous protein 1 (AUP1), transcript variant 2, mRNA;	343	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						GACTGGGGGCGCAATCTGGGG	0.512													50	129					0	0	0	0	A	74754875	A	A	74754875	3	1	166	1	0	0	0	0	1	0	0	0	1222	1087	38	1	423	1	AUP1	2	74754875	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	45183	74754875	168444498	131	30459											
LRRTM4	80059	broad.mit.edu	37	chr2	77746849	77746849	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatatctgcgaaagcatgaGactcacagtacacaattttg	14	10	9	8	1	2	1	1	1	1	1	2	4	2	2	0	1	3	2	0	1	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:77746849G>T	uc002snr.2	-	3	561	c.146C>A	c.(145-147)TCT>TAT	p.S49Y	LRRTM4_uc002snq.2_Missense_Mutation_p.S49Y|LRRTM4_uc002sns.2_Missense_Mutation_p.S49Y|LRRTM4_uc002snt.2_Missense_Mutation_p.S50Y	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	49	Extracellular (Potential).|LRRNT.					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GAAAGCATGAGACTCACAGTA	0.463													27	72					1.17739e-12	2.38644e-12	1	0	T	77746849	T	T	77746849	3	4	166	1	0	0	0	0	1	0	0	0	9092	942	33	2	1640	2	LRRTM4	2	77746849	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2991974	77746849	165452524	132	30460											
CTNNA2	1496	broad.mit.edu	37	chr2	80136847	80136847	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgcacgcgagacgaccGgcgcgagaggatcgtggcgg	7	4	17	13	8	0	2	0	0	0	2	2	6	1	3	2	4	1	1	2	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:80136847G>T	uc010ysh.1	+	6	985	c.980G>T	c.(979-981)CGG>CTG	p.R327L	CTNNA2_uc010yse.1_Missense_Mutation_p.R327L|CTNNA2_uc010ysf.1_Missense_Mutation_p.R327L|CTNNA2_uc010ysg.1_Missense_Mutation_p.R327L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	327					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CGAGACGACCGGCGCGAGAGG	0.637													33	74					5.8336e-16	1.2847e-15	1	0	T	80136847	T	T	80136847	3	4	166	1	0	0	0	0	1	0	0	0	4030	1116	39	3		3	CTNNA2	2	80136847	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2389998	80136847	163062526	133	30461											
CTNNA2	1496	broad.mit.edu	37	chr2	80816527	80816527	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctggatgcagaagtggcCaaatgggacgacagcggcaa	14	4	15	8	2	0	1	0	0	0	1	0	4	0	3	1	4	3	3	1	4	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:80816527C>G	uc010ysh.1	+	14	2111	c.2106C>G	c.(2104-2106)GCC>GCG	p.A702A	CTNNA2_uc010yse.1_Silent_p.A702A|CTNNA2_uc010ysf.1_Silent_p.A702A|CTNNA2_uc010ysg.1_Silent_p.A702A|CTNNA2_uc010ysi.1_Silent_p.A334A|CTNNA2_uc010ysj.1_Silent_p.A31A	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	702					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CAGAAGTGGCCAAATGGGACG	0.498													35	57					0	0	0	0	G	80816527	G	G	80816527	2	3	166	1	0	0	0	0	0	0	0	1	4030	581	21	4		4	CTNNA2	2	80816527	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	679680	80816527	162382846	134	30462											
PTCD3	55037	broad.mit.edu	37	chr2	86350830	86350830	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attattcatttcaggaagagGaaaatgatgagacatctagg	16	11	10	4	0	3	3	2	2	1	2	3	6	3	5	0	3	0	0	0	3	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:86350830G>T	uc002sqw.2	+	9	727	c.661G>T	c.(661-663)GAA>TAA	p.E221*	PTCD3_uc010ytc.1_RNA|PTCD3_uc002sqx.1_5'Flank	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	221						mitochondrion	protein binding			ovary(1)	1						TCAGGAAGAGGAAAATGATGA	0.383													14	36					3.27435e-08	6.05446e-08	1	0	T	86350830	T	T	86350830	4	4	166	1	0	0	0	0	0	1	0	0	12791	1175	41	2	695	2	PTCD3	2	86350830	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5534303	86350830	156848543	135	30463											
ADRA2B	151	broad.mit.edu	37	chr2	96780851	96780851	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgcccacctatagcaccCacgcccctgcccaggagcac	9	4	7	21	1	0	0	0	0	0	0	0	1	0	1	6	1	4	2	6	1	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:96780851C>A	uc002svi.2	-	3	1047	c.1047G>T	c.(1045-1047)GTG>GTT	p.V349V		NM_000682	NP_000673	P18089	ADA2B_HUMAN	alpha-2B-adrenergic receptor	349	Cytoplasmic (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			ovary(2)|lung(1)	3					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CTATAGCACCCACGCCCCTGC	0.677													7	16					0.00198382	0.00322679	1	0	A	96780851	A	A	96780851	2	1	166	1	0	0	0	0	0	0	0	1	338	581	21	4		4	ADRA2B	2	96780851	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	10430021	96780851	146418522	136	30464											
NCAPH	23397	broad.mit.edu	37	chr2	97008569	97008569	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttcttaaacagaaagacaccGaaccaaccaactttaaagta	19	8	4	10	1	1	2	0	0	1	2	1	3	1	2	3	0	4	1	3	0	9	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:97008569G>C	uc002svz.1	+	4	523	c.439G>C	c.(439-441)GAA>CAA	p.E147Q	NCAPH_uc010fhu.1_Missense_Mutation_p.E123Q|NCAPH_uc010fhv.1_Missense_Mutation_p.E136Q|NCAPH_uc010yum.1_Missense_Mutation_p.E123Q|NCAPH_uc010fhw.1_Missense_Mutation_p.E136Q|NCAPH_uc010yun.1_Missense_Mutation_p.E11Q|NCAPH_uc002swa.1_Intron	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	147					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				GAAAGACACCGAACCAACCAA	0.353													14	37					0	0	0	0	C	97008569	C	C	97008569	3	2	166	1	0	0	0	0	1	0	0	0	10263	1059	37	3	453	3	NCAPH	2	97008569	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	227718	97008569	146190804	137	30465											
FER1L5	90342	broad.mit.edu	37	chr2	97370351	97370351	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aacctaaagcctacaatagaCcatgagtggaaactccaccc	16	6	6	13	0	0	2	0	1	0	1	1	3	1	3	5	1	4	0	5	1	7	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:97370351C>A	uc010fia.2	+	52	6204	c.6204C>A	c.(6202-6204)GAC>GAA	p.D2068E	FER1L5_uc002sws.3_Missense_Mutation_p.D777E|FER1L5_uc002swt.3_Missense_Mutation_p.D777E|FER1L5_uc010yus.1_Missense_Mutation_p.D776E	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	2068						integral to membrane				ovary(1)	1						CTACAATAGACCATGAGTGGA	0.463													31	83					1.74807e-11	3.48193e-11	1	0	A	97370351	A	A	97370351	3	1	166	1	0	0	0	0	1	0	0	0	5846	506	18	4	6410	4	FER1L5	2	97370351	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	361782	97370351	145829022	138	30466											
INPP4A	3631	broad.mit.edu	37	chr2	99179952	99179952	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggagtgaggccctttaccCgctgctgaccactctcaccg	7	9	10	15	2	1	2	1	2	1	0	2	3	1	3	4	2	2	2	4	2	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:99179952C>T	uc002syy.2	+	19	2288	c.1895C>T	c.(1894-1896)CCG>CTG	p.P632L	INPP4A_uc010yvj.1_Missense_Mutation_p.P593L|INPP4A_uc010yvk.1_Missense_Mutation_p.P593L|INPP4A_uc002syx.2_Missense_Mutation_p.P627L|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	632					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						GCCCTTTACCCGCTGCTGACC	0.532													9	29					0	0	0	0	T	99179952	T	T	99179952	3	4	166	1	0	0	0	0	1	0	0	0	7791	652	23	1	1961	1	INPP4A	2	99179952	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1809601	99179952	144019421	139	30467											
CREG2	200407	broad.mit.edu	37	chr2	102000150	102000150	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgggcaggcagttcccaaaTggcagtccttggatctaaca	11	8	11	11	1	1	0	0	0	1	0	3	1	3	1	2	4	1	4	2	4	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:102000150T>C	uc002tba.2	-	2	502	c.456A>G	c.(454-456)CCA>CCG	p.P152P		NM_153836	NP_722578	Q8IUH2	CREG2_HUMAN	cellular repressor of E1A-stimulated genes 2	152						extracellular region	FMN binding			ovary(1)	1						AGTTCCCAAATGGCAGTCCTT	0.512													34	77					0	0	0	0	C	102000150	C	C	102000150	2	2	166	1	0	0	0	0	0	0	0	1	3880	1451	51	5		5	CREG2	2	102000150	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2820198	102000150	141199223	140	30468											
MFSD9	84804	broad.mit.edu	37	chr2	103353142	103353142	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagacagagcaggaagcggCgggctccgacggcaccggag	11	1	18	11	5	0	2	0	0	0	2	1	6	1	4	2	5	2	3	2	5	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:103353142C>G	uc002tcb.2	-	1	196	c.128G>C	c.(127-129)CGC>CCC	p.R43P	TMEM182_uc002tcc.3_5'Flank|TMEM182_uc002tcd.3_5'Flank|MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	43					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						CAGGAAGCGGCGGGCTCCGAC	0.672													14	42					0	0	0	0	G	103353142	G	G	103353142	3	3	166	1	0	0	0	0	1	0	0	0	9592	768	27	3	1320	3	MFSD9	2	103353142	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1352992	103353142	139846231	141	30469											
UXS1	80146	broad.mit.edu	37	chr2	106739524	106739524	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacgtggccccagtaatcctCactttgagggtggacttcag	8	10	11	12	1	2	1	2	1	0	0	3	2	3	2	3	3	0	1	3	3	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:106739524C>T	uc002tdm.2	-	9	744	c.646G>A	c.(646-648)GAG>AAG	p.E216K	UXS1_uc002tdl.2_Missense_Mutation_p.E48K|UXS1_uc002tdn.2_Missense_Mutation_p.E221K|UXS1_uc002tdo.2_Missense_Mutation_p.E159K|UXS1_uc010ywh.1_Missense_Mutation_p.E60K	NM_025076	NP_079352	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	216	Lumenal (Potential).				cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2						CAGTAATCCTCACTTTGAGGG	0.453													25	62					0	0	0	0	T	106739524	T	T	106739524	3	4	166	1	0	0	0	0	1	0	0	0	17177	835	29	2	644	2	UXS1	2	106739524	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3386382	106739524	136459849	142	30470											
SULT1C3	442038	broad.mit.edu	37	chr2	108863754	108863754	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgatattatcaaaagaatGgtgggaaaaagtatgtaatt	17	13	10	1	0	1	2	1	1	0	1	1	3	1	3	0	2	0	3	0	2	9	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:108863754G>T	uc010ywo.1	+	1	104	c.104G>T	c.(103-105)TGG>TTG	p.W35L		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	35						cytoplasm	alcohol sulfotransferase activity			skin(1)	1						TCAAAAGAATGGTGGGAAAAA	0.378													18	53					3.99206e-14	8.40433e-14	1	0	T	108863754	T	T	108863754	3	4	166	1	0	0	0	0	1	0	0	0	15444	1357	47	4	106	4	SULT1C3	2	108863754	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2124230	108863754	134335619	143	30471											
FBLN7	129804	broad.mit.edu	37	chr2	112944822	112944822	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacctgaagacgcccatcacGctcttccgcatggccacagc	10	6	8	17	3	2	2	1	1	1	1	3	2	3	2	4	1	2	2	4	1	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:112944822G>T	uc002tho.1	+	8	1330	c.1059G>T	c.(1057-1059)ACG>ACT	p.T353T	FBLN7_uc002thn.2_Intron|FBLN7_uc010fki.1_Silent_p.T307T|FBLN7_uc010fkj.1_Silent_p.T219T	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	353					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						CGCCCATCACGCTCTTCCGCA	0.647													38	103					4.14481e-20	9.64825e-20	1	0	T	112944822	T	T	112944822	2	4	166	1	0	0	0	0	0	0	0	1	5733	1074	38	3		3	FBLN7	2	112944822	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4081068	112944822	130254551	144	30472											
SLC35F5	80255	broad.mit.edu	37	chr2	114503857	114503857	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaaaagaagcacttaccaaAgaactattcatagttgtatc	18	10	6	7	0	1	3	1	0	0	3	2	3	1	3	1	0	3	3	1	0	9	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:114503857A>T	uc002tku.1	-	5	901	c.477T>A	c.(475-477)TCT>TCA	p.S159S	SLC35F5_uc002tkt.2_RNA|SLC35F5_uc002tkv.2_Silent_p.S153S|SLC35F5_uc002tkw.2_Silent_p.S159S	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	159					transport	integral to membrane					0						CACTTACCAAAGAACTATTCA	0.378													16	39					0	0	0	0	T	114503857	T	T	114503857	2	4	166	1	0	0	0	0	0	0	0	1	14656	59	3	5		5	SLC35F5	2	114503857	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1559035	114503857	128695516	145	30473											
STEAP3	55240	broad.mit.edu	37	chr2	120003239	120003239	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggcttcaaagtggtggTggggagccgcaaccccaaac	9	7	13	12	1	2	0	1	0	1	0	2	1	2	1	3	5	3	2	3	5	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:120003239T>A	uc002tlp.2	+	3	324	c.167T>A	c.(166-168)GTG>GAG	p.V56E	STEAP3_uc002tlq.2_Missense_Mutation_p.V66E|STEAP3_uc002tlr.2_Missense_Mutation_p.V56E|STEAP3_uc010fle.2_Missense_Mutation_p.V56E	NM_018234	NP_060704	Q658P3	STEA3_HUMAN	dudulin 2 isoform b	56	Cytoplasmic (Potential).				apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			central_nervous_system(2)|skin(1)	3						AAAGTGGTGGTGGGGAGCCGC	0.637													11	31					0	0	0	0	A	120003239	A	A	120003239	3	1	166	1	0	0	0	0	1	0	0	0	15345	1696	59	5	203	5	STEAP3	2	120003239	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5499382	120003239	123196134	146	30474											
GLI2	2736	broad.mit.edu	37	chr2	121747847	121747847	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actactacggccagatccacAtgtacgaacaggatggaggc	13	6	11	11	2	0	1	0	0	0	1	1	4	1	3	2	4	4	1	2	4	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:121747847A>G	uc010flp.2	+	13	4387	c.4357A>G	c.(4357-4359)ATG>GTG	p.M1453V	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Missense_Mutation_p.M1125V|GLI2_uc002tmu.3_Missense_Mutation_p.M1108V	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1453					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CCAGATCCACATGTACGAACA	0.657													24	64					0	0	0	0	G	121747847	G	G	121747847	3	3	166	1	0	0	0	0	1	0	0	0	6475	217	8	5	4407	5	GLI2	2	121747847	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1744608	121747847	121451526	147	30475											
CNTNAP5	129684	broad.mit.edu	37	chr2	125175132	125175132	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atggaatcccagtgggaagaTtggcatgagagtcgaggtct	11	9	15	6	1	1	2	0	1	1	2	3	6	2	4	1	4	0	1	1	4	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:125175132T>C	uc002tno.2	+	4	858	c.494T>C	c.(493-495)ATT>ACT	p.I165T	CNTNAP5_uc010flu.2_Missense_Mutation_p.I165T	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	165	F5/8 type C.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AGTGGGAAGATTGGCATGAGA	0.498													3	16					0	0	0	0	C	125175132	C	C	125175132	3	2	166	1	0	0	0	0	1	0	0	0	3665	1493	52	5	508	5	CNTNAP5	2	125175132	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	3427285	125175132	118024241	148	30476											
FAM123C	205147	broad.mit.edu	37	chr2	131520349	131520349	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtctctgcagggccctgtGtgaggacgtggcctcactcc	4	10	14	13	1	2	1	1	1	1	0	4	2	3	2	3	4	1	1	3	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:131520349G>A	uc002trw.2	+	2	894	c.704G>A	c.(703-705)TGT>TAT	p.C235Y	FAM123C_uc010fmv.2_Missense_Mutation_p.C235Y|FAM123C_uc010fms.1_Missense_Mutation_p.C235Y|FAM123C_uc010fmt.1_Missense_Mutation_p.C235Y|FAM123C_uc010fmu.1_Missense_Mutation_p.C235Y	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	235										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		AGGGCCCTGTGTGAGGACGTG	0.662													26	130					0	0	0	0	A	131520349	A	A	131520349	3	1	166	1	0	0	0	0	1	0	0	0	5452	1377	48	4	706	4	FAM123C	2	131520349	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	6345217	131520349	111679024	149	30477											
NCKAP5	344148	broad.mit.edu	37	chr2	133540264	133540264	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaggagtccctcagactttgGagggatcctcaaaggcaact	11	8	12	10	0	2	1	2	0	0	1	4	5	4	4	2	4	1	1	2	4	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:133540264G>C	uc002ttp.2	-	14	4494	c.4120C>G	c.(4120-4122)CCA>GCA	p.P1374A	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1374							protein binding				0						TCAGACTTTGGAGGGATCCTC	0.622													15	30					0	0	0	0	C	133540264	C	C	133540264	3	2	166	1	0	0	0	0	1	0	0	0	10277	1174	41	2	1637	2	NCKAP5	2	133540264	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2019915	133540264	109659109	150	30478											
ORC4L	5000	broad.mit.edu	37	chr2	148696734	148696734	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatatttgctttcgagtcCatgctacacagttggcttgc	9	14	8	10	1	0	0	0	0	0	0	2	1	1	0	1	1	4	4	1	1	3	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:148696734C>A	uc002twi.2	-	11	1068	c.933G>T	c.(931-933)ATG>ATT	p.M311I	ORC4L_uc002twj.2_Missense_Mutation_p.M311I|ORC4L_uc010zbo.1_Missense_Mutation_p.M237I|ORC4L_uc010zbp.1_Missense_Mutation_p.M94I|ORC4L_uc010fnr.2_Missense_Mutation_p.M311I|ORC4L_uc010zbq.1_Missense_Mutation_p.M227I|ORC4L_uc002twk.2_Missense_Mutation_p.M311I|ORC4L_uc010zbr.1_Missense_Mutation_p.M311I|ORC4L_uc002twl.1_5'Flank	NM_181741	NP_859525	O43929	ORC4_HUMAN	origin recognition complex subunit 4	311					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|nucleoside-triphosphatase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.0963)|COAD - Colon adenocarcinoma(177;0.203)		CTTTCGAGTCCATGCTACACA	0.358													14	31					2.32078e-09	4.43347e-09	1	0	A	148696734	A	A	148696734	3	1	166	1	0	0	0	0	1	0	0	0	11318	594	21	4	393	4	ORC4L	2	148696734	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	15156470	148696734	94502639	151	30479											
FAP	2191	broad.mit.edu	37	chr2	163027550	163027550	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggtgtataagtggttcGtggacaggccggataagccg	8	10	17	6	3	0	0	0	0	0	0	1	2	0	2	2	5	1	2	2	5	3	4	rs138652824		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:163027550G>T	uc002ucd.2	-	26	2430	c.2222C>A	c.(2221-2223)ACG>AAG	p.T741K	FAP_uc010fpc.2_Missense_Mutation_p.T290K|FAP_uc010zct.1_Missense_Mutation_p.T716K|FAP_uc010fpd.2_Missense_Mutation_p.T220K	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	741	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity	p.T741K(1)		ovary(3)	3						TAAGTGGTTCGTGGACAGGCC	0.433													28	38					7.38237e-10	1.42556e-09	1	0	T	163027550	T	T	163027550	3	4	166	1	0	0	0	0	1	0	0	0	5705	1145	40	3	64	3	FAP	2	163027550	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	14330816	163027550	80171823	152	30480											
SCN3A	6328	broad.mit.edu	37	chr2	166019263	166019263	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagagcaaacacgctcagaCagaacacagtcaggatcatc	16	5	9	11	1	3	3	3	1	0	3	4	5	3	4	0	1	3	2	0	1	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:166019263C>A	uc002ucx.2	-	8	1262	c.770G>T	c.(769-771)TGT>TTT	p.C257F	SCN3A_uc002ucy.2_Missense_Mutation_p.C257F|SCN3A_uc002ucz.2_Missense_Mutation_p.C257F|SCN3A_uc002uda.1_Missense_Mutation_p.C126F|SCN3A_uc002udb.1_Missense_Mutation_p.C126F	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	257	Helical; Name=S5 of repeat I; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CACGCTCAGACAGAACACAGT	0.478													37	36					1.90571e-15	4.14101e-15	1	0	A	166019263	A	A	166019263	3	1	166	1	0	0	0	0	1	0	0	0	13983	478	17	4	5316	4	SCN3A	2	166019263	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2991713	166019263	77180110	153	30481											
XIRP2	129446	broad.mit.edu	37	chr2	168105477	168105477	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaaatctcattcatttccAgagagttcaggacaacaaaa	18	10	5	8	0	3	1	3	0	1	1	5	3	4	2	1	1	1	1	1	1	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:168105477A>T	uc002udx.2	+	8	7593	c.7575A>T	c.(7573-7575)CCA>CCT	p.P2525P	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.P2350P|XIRP2_uc010fpq.2_Silent_p.P2303P|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2350					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATTCATTTCCAGAGAGTTCAG	0.348													32	51					0	0	0	0	T	168105477	T	T	168105477	2	4	166	1	0	0	0	0	0	0	0	1	17498	175	7	5		5	XIRP2	2	168105477	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2086214	168105477	75093896	154	30482											
LRP2	4036	broad.mit.edu	37	chr2	170096254	170096254	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaacacactcgtgagtacaAccaccattgaaatctgagca	15	8	7	11	1	1	4	0	4	1	0	2	4	1	4	2	0	4	2	2	0	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:170096254A>T	uc002ues.2	-	26	4290	c.4077T>A	c.(4075-4077)GGT>GGA	p.G1359G		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1359	Extracellular (Potential).|EGF-like 5.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CGTGAGTACAACCACCATTGA	0.383													17	27					0	0	0	0	T	170096254	T	T	170096254	2	4	166	1	0	0	0	0	0	0	0	1	9006	30	2	5		5	LRP2	2	170096254	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1990777	170096254	73103119	155	30483											
SSB	6741	broad.mit.edu	37	chr2	170667535	170667535	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaagaccaacaagaatccctAaacaaatggaagtcaaaagg	21	4	8	8	0	1	2	1	0	0	2	2	4	2	3	2	2	2	0	2	2	10	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:170667535A>G	uc002ufk.2	+	10	1085	c.978A>G	c.(976-978)CTA>CTG	p.L326L	SSB_uc002ufl.2_Silent_p.L326L|SSB_uc002ufm.2_Silent_p.L326L	NM_003142	NP_003133	P05455	LA_HUMAN	autoantigen La	326					histone mRNA metabolic process|tRNA modification	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding|tRNA binding			skin(3)|pancreas(1)	4						AAGAATCCCTAAACAAATGGA	0.333													14	27					0	0	0	0	G	170667535	G	G	170667535	2	3	166	1	0	0	0	0	0	0	0	1	15244	349	13	5		5	SSB	2	170667535	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	571281	170667535	72531838	156	30484											
TTN	7273	broad.mit.edu	37	chr2	179392225	179392225	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagctttccagttgtgtcatAttagatattcccataaagct	11	15	7	8	0	1	1	1	0	0	1	3	2	3	1	2	0	2	3	2	0	5	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:179392225A>G	uc010zfg.1	-	311	100148	c.99924T>C	c.(99922-99924)AAT>AAC	p.N33308N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.N27003N|TTN_uc010zfi.1_Silent_p.N26936N|TTN_uc010zfj.1_Silent_p.N26811N|TTN_uc002umq.2_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	34235							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGTGTCATATTAGATATTC	0.403													38	56					0	0	0	0	G	179392225	G	G	179392225	2	3	166	1	0	0	0	0	0	0	0	1	16803	446	16	5		5	TTN	2	179392225	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	8724690	179392225	63807148	157	30485											
TTN	7273	broad.mit.edu	37	chr2	179457788	179457788	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtatctattgcttcaggAttaacaggtggacttggttt	8	17	11	5	0	2	0	1	0	1	0	2	2	2	2	0	4	2	4	0	4	3	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:179457788A>T	uc010zfg.1	-	249	51578	c.51354T>A	c.(51352-51354)AAT>AAA	p.N17118K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N10813K|TTN_uc010zfi.1_Missense_Mutation_p.N10746K|TTN_uc010zfj.1_Missense_Mutation_p.N10621K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18045							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCTTCAGGATTAACAGGTG	0.358													45	52					0	0	0	0	T	179457788	T	T	179457788	3	4	166	1	0	0	0	0	1	0	0	0	16803	330	12	5	49173	5	TTN	2	179457788	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	65563	179457788	63741585	158	30486											
TTN	7273	broad.mit.edu	37	chr2	179482516	179482516	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgggcttaccaattggatcAgcaactttgacgaagggtgt	11	11	12	7	1	1	1	1	1	0	0	1	3	1	2	1	3	3	2	1	3	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:179482516A>T	uc010zfg.1	-	202	40082	c.39858T>A	c.(39856-39858)GCT>GCA	p.A13286A	TTN_uc010zfh.1_Silent_p.A6981A|TTN_uc010zfi.1_Silent_p.A6914A|TTN_uc010zfj.1_Silent_p.A6789A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14213							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAATTGGATCAGCAACTTTGA	0.388													17	35					0	0	0	0	T	179482516	T	T	179482516	2	4	166	1	0	0	0	0	0	0	0	1	16803	175	7	5		5	TTN	2	179482516	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	24728	179482516	63716857	159	30487											
COL3A1	1281	broad.mit.edu	37	chr2	189854843	189854843	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaatcaggtagacccggaCgacctggagagcgaggattg	12	5	16	8	3	1	3	1	0	0	3	1	9	1	5	2	4	1	1	2	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:189854843C>A	uc002uqj.1	+	9	829	c.712C>A	c.(712-714)CGA>AGA	p.R238R	COL3A1_uc010frw.1_5'Flank	NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	238	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TAGACCCGGACGACCTGGAGA	0.383													13	23					0.00244969	0.00397796	1	0	A	189854843	A	A	189854843	2	1	166	1	0	0	0	0	0	0	0	1	3703	528	19	3		3	COL3A1	2	189854843	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	10372327	189854843	53344530	160	30488											
PLCL1	5334	broad.mit.edu	37	chr2	198950550	198950550	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaagaactaaaactgtacAgcaaaacagtgataatccta	21	7	5	8	0	0	2	0	1	0	1	1	2	1	2	1	0	5	2	1	0	9	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:198950550A>T	uc010fsp.2	+	2	2600	c.2309A>T	c.(2308-2310)CAG>CTG	p.Q770L	PLCL1_uc002uuv.3_Missense_Mutation_p.Q691L	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	770	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AAAACTGTACAGCAAAACAGT	0.408													20	37					0	0	0	0	T	198950550	T	T	198950550	3	4	166	1	0	0	0	0	1	0	0	0	12094	188	7	5	2315	5	PLCL1	2	198950550	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	9095707	198950550	44248823	161	30489											
CASP8	841	broad.mit.edu	37	chr2	202137359	202137359	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actttatttctcctcctcttAgaacctgctggatattttca	8	18	4	11	0	3	1	1	0	2	1	5	2	4	2	3	1	2	1	3	1	4	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:202137359A>G	uc002uxr.1	+	5	621	c.412_splice	c.e5-2	p.N138_splice	CASP8_uc010ftc.1_Splice_Site_p.N138_splice|CASP8_uc002uxo.1_Splice_Site_p.N138_splice|CASP8_uc002uxp.1_Splice_Site_p.N170_splice|CASP8_uc002uxq.1_Splice_Site_p.N138_splice|CASP8_uc002uxs.1_Splice_Site_p.N138_splice|CASP8_uc002uxt.1_Splice_Site_p.N197_splice|CASP8_uc002uxu.1_Splice_Site|CASP8_uc010ftd.1_Splice_Site_p.N35_splice|CASP8_uc002uxv.1_Splice_Site_p.N138_splice|CASP8_uc002uxw.1_Splice_Site_p.N138_splice|CASP8_uc002uxy.1_Splice_Site_p.N138_splice|CASP8_uc002uxx.1_Splice_Site_p.N138_splice|CASP8_uc010ftf.2_Splice_Site_p.N138_splice|CASP8_uc010fte.1_Splice_Site_p.N35_splice	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor						activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TCCTCCTCTTAGAACCTGCTG	0.408										HNSCC(4;0.00038)			27	52					0	0	0	0	G	202137359	G	G	202137359	5	3	166	1	0	0	0	0	0	0	1	0	2689	434	15	5	701	5	CASP8	2	202137359	Splice_Site	SNP	A	TCGA-CR-7402-01A-11D-2012-08	3186809	202137359	41062014	162	30490											
ZDBF2	57683	broad.mit.edu	37	chr2	207176110	207176110	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagagctgtcaagcgctatGgcaaatcctcctccaaagcg	12	7	10	12	2	1	1	1	0	0	1	4	2	4	1	3	1	3	3	3	1	5	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:207176110G>T	uc002vbp.2	+	5	7108	c.6858G>T	c.(6856-6858)ATG>ATT	p.M2286I		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2286							nucleic acid binding|zinc ion binding			ovary(3)	3						CAAGCGCTATGGCAAATCCTC	0.507													8	4					0.000274275	0.000453271	1	0	T	207176110	T	T	207176110	3	4	166	1	0	0	0	0	1	0	0	0	17666	1348	47	4	6868	4	ZDBF2	2	207176110	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5038751	207176110	36023263	163	30491											
IDH1	3417	broad.mit.edu	37	chr2	209116227	209116227	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaatgattcgtgtcatttCatctccttgcatctctacca	9	15	4	13	1	4	1	2	1	2	0	7	1	4	1	3	0	2	1	3	0	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:209116227C>T	uc002vcs.2	-	3	295	c.49G>A	c.(49-51)GAA>AAA	p.E17K	IDH1_uc002vct.2_Missense_Mutation_p.E17K|IDH1_uc002vcu.2_Missense_Mutation_p.E17K	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	17					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		CGTGTCATTTCATCTCCTTGC	0.358			Mis		gliobastoma 								27	31					0	0	0	0	T	209116227	T	T	209116227	3	4	166	1	0	0	0	0	1	0	0	0	7533	835	29	2	1227	2	IDH1	2	209116227	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1940117	209116227	34083146	164	30492											
PTH2R	5746	broad.mit.edu	37	chr2	209308084	209308084	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctccgtagacgattgcattGcactaggaactatatccaca	12	11	7	11	2	1	1	0	0	1	1	3	3	2	2	2	1	3	3	2	1	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:209308084G>A	uc002vdb.2	+	6	734	c.521G>A	c.(520-522)TGC>TAC	p.C174Y	PTH2R_uc010zjb.1_Missense_Mutation_p.C185Y	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	174	Cytoplasmic (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		CGATTGCATTGCACTAGGAAC	0.418													17	20					0	0	0	0	A	209308084	A	A	209308084	3	1	166	1	0	0	0	0	1	0	0	0	12823	1319	46	4	543	4	PTH2R	2	209308084	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	191857	209308084	33891289	165	30493											
ACADL	33	broad.mit.edu	37	chr2	211085399	211085399	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgaggaatcacttcttcttGgaaaaacttccttacacttt	12	15	5	9	0	3	1	1	1	2	0	4	3	4	3	1	2	2	0	1	2	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:211085399G>T	uc002vdz.3	-	2	433	c.205C>A	c.(205-207)CAA>AAA	p.Q69K	ACADL_uc010zjg.1_Missense_Mutation_p.Q69K	NM_001608	NP_001599	P28330	ACADL_HUMAN	long-chain acyl-CoA dehydrogenase precursor	69					carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity				0		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		ACTTCTTCTTGGAAAAACTTC	0.358													18	23					1.00905e-13	2.09728e-13	1	0	T	211085399	T	T	211085399	3	4	166	1	0	0	0	0	1	0	0	0	112	1357	47	4	1127	4	ACADL	2	211085399	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1777315	211085399	32113974	166	30494											
ERBB4	2066	broad.mit.edu	37	chr2	212812196	212812196	+	Frame_Shift_Del	DEL	C	-	-																															gttcttgaagtccaaagtttCcatcttttctgtagtttaaa																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:212812196delC	uc002veg.1	-	3	478	c.380delG	c.(379-381)GGAfs	p.G127fs	ERBB4_uc002veh.1_Frame_Shift_Del_p.G127fs|ERBB4_uc010zji.1_Frame_Shift_Del_p.G127fs|ERBB4_uc010zjj.1_Frame_Shift_Del_p.G127fs|ERBB4_uc010fut.1_Frame_Shift_Del_p.G127fs	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	127	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCCAAAGTTTCCATCTTTTCT	0.338										TSP Lung(8;0.080)			---	---	---								-	212812196	-	-	212812196	7	5	166	1	0	1	0	1	0	0	0	0	5233	855	30	0	3650	0	ERBB4	2	212812196	Frame_Shift_Del	DEL	C	TCGA-CR-7402-01A-11D-2012-08	1726797	212812196	30387177	167	30495											
ABCA12	26154	broad.mit.edu	37	chr2	215976318	215976318	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taaacaaatgtcatttacttAcaagttggttttgcagttgg	12	16	8	5	0	1	0	1	0	0	0	1	0	1	0	0	2	4	4	0	2	6	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:215976318A>T	uc002vew.2	-	2	383	c.163_splice	c.e2+1	p.C55_splice	ABCA12_uc010zjn.1_Splice_Site	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12						cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCATTTACTTACAAGTTGGTT	0.294													19	22					0	0	0	0	T	215976318	T	T	215976318	5	4	166	1	0	0	0	0	0	0	1	0	30	405	14	5	7861	5	ABCA12	2	215976318	Splice_Site	SNP	A	TCGA-CR-7402-01A-11D-2012-08	3164122	215976318	27223055	168	30496											
ANKZF1	55139	broad.mit.edu	37	chr2	220095004	220095004	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgccggctccagatgcagccCcggctcctgcgtcgatctcc	4	7	11	19	5	1	1	0	0	1	1	5	2	3	1	6	2	3	3	6	2	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:220095004C>T	uc002vkg.2	+	2	199	c.25C>T	c.(25-27)CCG>TCG	p.P9S	ATG9A_uc002vke.1_5'Flank|ATG9A_uc002vkf.1_5'Flank|ANKZF1_uc010zkv.1_Missense_Mutation_p.P9S|ANKZF1_uc010zkw.1_Intron|ANKZF1_uc002vkh.2_Intron|ANKZF1_uc002vki.2_Missense_Mutation_p.P9S|ANKZF1_uc002vkj.1_5'Flank	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	9						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGATGCAGCCCCGGCTCCTGC	0.612													11	22					0	0	0	0	T	220095004	T	T	220095004	3	4	166	1	0	0	0	0	1	0	0	0	693	623	22	4	27	4	ANKZF1	2	220095004	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4118686	220095004	23104369	169	30497											
DOCK10	55619	broad.mit.edu	37	chr2	225639746	225639746	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atttcgaaatctgtcttccgGtcttcgatttccttttcctc	5	19	5	12	3	3	0	0	0	3	0	9	2	6	0	3	1	0	0	3	1	1	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:225639746G>T	uc010fwz.1	-	52	6128	c.5889C>A	c.(5887-5889)GAC>GAA	p.D1963E	DOCK10_uc002vob.2_Missense_Mutation_p.D1957E|DOCK10_uc002voa.2_Missense_Mutation_p.D619E	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1963	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTGTCTTCCGGTCTTCGATTT	0.507													7	14					8.12818e-05	0.000136164	1	0	T	225639746	T	T	225639746	3	4	166	1	0	0	0	0	1	0	0	0	4707	1252	44	4	691	4	DOCK10	2	225639746	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5544742	225639746	17559627	170	30498											
SPHKAP	80309	broad.mit.edu	37	chr2	228881633	228881633	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcatgagagcctcaatggAgctagcccacgtttcatgaa	11	8	11	11	2	2	2	2	2	0	1	2	4	2	3	2	1	3	3	2	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:228881633A>C	uc002vpq.2	-	7	3984	c.3937T>G	c.(3937-3939)TCC>GCC	p.S1313A	SPHKAP_uc002vpp.2_Missense_Mutation_p.S1313A|SPHKAP_uc010zlx.1_Missense_Mutation_p.S1313A	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1313						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCCTCAATGGAGCTAGCCCAC	0.507													17	27					0	0	0	0	C	228881633	C	C	228881633	3	2	166	1	0	0	0	0	1	0	0	0	15114	304	11	5	1189	5	SPHKAP	2	228881633	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	3241887	228881633	14317740	171	30499											
FGD5	152273	broad.mit.edu	37	chr3	14939485	14939485	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctgacgtcttcctggcccgGgagcaggggtttgatcacca	6	9	14	12	2	2	2	1	2	1	0	3	3	3	3	3	4	1	3	3	4	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:14939485G>A	uc003bzc.2	+	6	3059	c.2949G>A	c.(2947-2949)CGG>CGA	p.R983R	FGD5_uc011avk.1_Silent_p.R983R|FGD5_uc003bzd.2_Silent_p.R61R	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	983	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						TCCTGGCCCGGGAGCAGGGGT	0.577													24	38					0	0	0	0	A	14939485	A	A	14939485	2	1	166	1	0	0	0	0	0	0	0	1	5868	1219	43	4		4	FGD5	3	14939485	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08		14939485	183082945	172	30500											
RFTN1	23180	broad.mit.edu	37	chr3	16475401	16475401	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctctaaagatgtgctccaGgggcgtcttctcccgctcat	6	11	11	13	2	4	1	1	0	3	1	6	1	5	1	2	3	1	3	2	3	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:16475401G>T	uc003cay.2	-	3	571	c.289C>A	c.(289-291)CTG>ATG	p.L97M	RFTN1_uc010hes.2_Missense_Mutation_p.L61M	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	97						plasma membrane				ovary(3)|central_nervous_system(1)	4						ATGTGCTCCAGGGGCGTCTTC	0.597													50	103					2.55665e-31	6.35917e-31	1	0	T	16475401	T	T	16475401	3	4	166	1	0	0	0	0	1	0	0	0	13323	991	35	4	1479	4	RFTN1	3	16475401	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1535916	16475401	181547029	173	30501											
ZNF385D	79750	broad.mit.edu	37	chr3	21465512	21465512	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggactgtatttaggtttcggGggcttcccagcagctctgtc	5	13	13	10	1	1	0	0	0	1	0	4	1	2	1	1	4	2	5	1	4	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:21465512G>T	uc003cce.2	-	7	1305	c.897C>A	c.(895-897)CCC>CCA	p.P299P		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	299						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						TAGGTTTCGGGGGCTTCCCAG	0.418													34	40					2.54651e-27	6.22338e-27	1	0	T	21465512	T	T	21465512	2	4	166	1	0	0	0	0	0	0	0	1	17945	1219	43	4		4	ZNF385D	3	21465512	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4990111	21465512	176556918	174	30502											
ZNF385D	79750	broad.mit.edu	37	chr3	21606087	21606087	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcagaattaaatctcaactgGcaaatgttgcatgatatgat	15	13	7	6	0	2	3	2	2	1	1	3	3	2	3	0	1	2	3	0	1	6	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:21606087G>T	uc003cce.2	-	3	663	c.255C>A	c.(253-255)TGC>TGA	p.C85*	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	85	Matrin-type 1.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						ATCTCAACTGGCAAATGTTGC	0.343													15	28					3.27435e-08	6.05446e-08	1	0	T	21606087	T	T	21606087	4	4	166	1	0	0	0	0	0	1	0	0	17945	1195	42	4	956	4	ZNF385D	3	21606087	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	140575	21606087	176416343	175	30503											
TGFBR2	7048	broad.mit.edu	37	chr3	30691784	30691784	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaagaatgacgagaacataAcactagagacagtttgccat	18	7	9	7	1	0	4	0	1	0	3	0	7	0	4	1	0	3	1	1	0	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:30691784A>G	uc003ceo.2	+	3	668	c.286A>G	c.(286-288)ACA>GCA	p.T96A	TGFBR2_uc003cen.2_Missense_Mutation_p.T121A	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	96	Extracellular (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CGAGAACATAACACTAGAGAC	0.428													27	34					0	0	0	0	G	30691784	G	G	30691784	3	3	166	1	0	0	0	0	1	0	0	0	15888	43	2	5	375	5	TGFBR2	3	30691784	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	9085697	30691784	167330646	176	30504											
TRANK1	9881	broad.mit.edu	37	chr3	36899135	36899135	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcaggcagtgttctggcaGtggcaccacatggcactgac	8	9	12	12	0	2	1	1	1	1	0	2	1	2	1	1	4	0	5	1	4	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:36899135G>T	uc003cgj.2	-	3	598	c.296C>A	c.(295-297)ACT>AAT	p.T99N		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	649					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TGTTCTGGCAGTGGCACCACA	0.597													35	34					1.26612e-14	2.70326e-14	1	0	T	36899135	T	T	36899135	3	4	166	1	0	0	0	0	1	0	0	0	16521	1029	36	4	6879	4	TRANK1	3	36899135	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	6207351	36899135	161123295	177	30505											
SCN10A	6336	broad.mit.edu	37	chr3	38763808	38763808	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctctcaaaccagctgtgctCcacgatacggtagcaagtct	10	9	9	13	2	2	0	1	0	2	0	4	1	3	0	2	1	5	5	2	1	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:38763808C>A	uc003ciq.2	-	19	3448	c.3448G>T	c.(3448-3450)GAG>TAG	p.E1150*		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1150	III.|Helical; Name=S1 of repeat III; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAGCTGTGCTCCACGATACGG	0.547													20	33					0.000132079	0.000220506	1	0	A	38763808	A	A	38763808	4	1	166	1	0	0	0	0	0	1	0	0	13977	864	30	2	2458	2	SCN10A	3	38763808	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1864673	38763808	159258622	178	30506											
SCN11A	11280	broad.mit.edu	37	chr3	38946691	38946691	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtggaacttacccttcatgGtgatggtgaggatgctgaca	9	12	13	7	0	1	3	1	3	0	0	1	5	1	5	1	4	3	1	1	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:38946691G>T	uc011ays.1	-	11	1794	c.1595C>A	c.(1594-1596)ACC>AAC	p.T532N		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	532					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ACCCTTCATGGTGATGGTGAG	0.488													57	58					6.176e-18	1.3978e-17	1	0	T	38946691	T	T	38946691	3	4	166	1	0	0	0	0	1	0	0	0	13978	1261	44	4	3844	4	SCN11A	3	38946691	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	182883	38946691	159075739	179	30507											
CCR8	1237	broad.mit.edu	37	chr3	39374449	39374449	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aacattttaggcttgttgatCccattcaccatctttatgtt	9	18	5	9	0	2	1	1	1	1	0	3	1	3	1	2	1	1	3	2	1	3	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:39374449C>T	uc010hhr.2	+	2	765	c.627C>T	c.(625-627)ATC>ATT	p.I209I	CCR8_uc003cjm.2_Silent_p.I126I	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	209	Helical; Name=5; (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		GCTTGTTGATCCCATTCACCA	0.398													25	34					0	0	0	0	T	39374449	T	T	39374449	2	4	166	1	0	0	0	0	0	0	0	1	2962	845	30	2		2	CCR8	3	39374449	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	427758	39374449	158647981	180	30508											
CCK	885	broad.mit.edu	37	chr3	42304950	42304950	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttgccagcagggcgcccAggtgcgctcgggactcgcca	6	6	14	15	4	1	0	0	0	1	0	3	1	1	1	3	3	3	2	3	3	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:42304950A>T	uc003clc.1	-	2	382	c.173T>A	c.(172-174)CTG>CAG	p.L58Q	CCK_uc003cld.1_Missense_Mutation_p.L58Q|CCK_uc011azk.1_Missense_Mutation_p.L58Q	NM_000729	NP_000720	P06307	CCKN_HUMAN	cholecystokinin preproprotein	58					axonogenesis|eating behavior|neuron migration		neuropeptide hormone activity			central_nervous_system(1)	1		Ovarian(412;0.0728)		KIRC - Kidney renal clear cell carcinoma(284;0.219)		CAGGGCGCCCAGGTGCGCTCG	0.672													32	58					0	0	0	0	T	42304950	T	T	42304950	3	4	166	1	0	0	0	0	1	0	0	0	2892	188	7	5	182	5	CCK	3	42304950	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2930501	42304950	155717480	181	30509											
C3orf23	285343	broad.mit.edu	37	chr3	44441904	44441904	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggctgatgattttagaaGaccaaataagctatctttta	14	13	9	5	0	1	4	0	2	1	2	1	5	1	5	1	2	1	2	1	2	6	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:44441904G>T	uc010him.2	+	9	1188	c.943G>T	c.(943-945)GAC>TAC	p.D315Y	C3orf23_uc003cnd.3_Missense_Mutation_p.D315Y|C3orf23_uc003cne.3_Missense_Mutation_p.D171Y	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	315						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		GATTTTAGAAGACCAAATAAG	0.318													11	25					1.58986e-06	2.79725e-06	1	0	T	44441904	T	T	44441904	3	4	166	1	0	0	0	0	1	0	0	0	2226	942	33	2	1025	2	C3orf23	3	44441904	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2136954	44441904	153580526	182	30510											
CSPG5	10675	broad.mit.edu	37	chr3	47618790	47618790	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaggaaggggtctctccCtcagtatcagggtggttctc	6	11	12	12	0	4	0	2	0	2	0	8	1	6	1	2	5	0	2	2	5	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:47618790C>T	uc003crp.3	-	2	902	c.726G>A	c.(724-726)GAG>GAA	p.E242E	CSPG5_uc003crn.2_Silent_p.E104E|CSPG5_uc003cro.3_Silent_p.E242E|CSPG5_uc011bbb.1_Silent_p.E104E	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	242	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GGGTCTCTCCCTCAGTATCAG	0.517													9	12					0	0	0	0	T	47618790	T	T	47618790	2	4	166	1	0	0	0	0	0	0	0	1	3978	680	24	4		4	CSPG5	3	47618790	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3176886	47618790	150403640	183	30511											
USP4	7375	broad.mit.edu	37	chr3	49377429	49377429	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tctgagtctccgcatccggtCgctcacggcagcctccacct	5	9	9	18	4	3	1	1	1	2	0	7	1	5	1	5	2	1	3	5	2	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:49377429C>G	uc003cwq.2	-	1	108	c.29G>C	c.(28-30)CGA>CCA	p.R10P	USP4_uc003cwr.2_Missense_Mutation_p.R10P	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	10					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		CGCATCCGGTCGCTCACGGCA	0.697													6	24					0	0	0	0	G	49377429	G	G	49377429	3	3	166	1	0	0	0	0	1	0	0	0	17139	884	31	3	2950	3	USP4	3	49377429	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1758639	49377429	148645001	184	30512											
CACNA1D	776	broad.mit.edu	37	chr3	53781378	53781378	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttgacagtcctgtggtcCgtgaacggatctggcaaaac	10	10	12	9	2	1	2	0	2	1	0	3	3	3	3	2	3	2	2	2	3	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:53781378C>A	uc003dgv.3	+	26	3380	c.3217C>A	c.(3217-3219)CGT>AGT	p.R1073S	CACNA1D_uc003dgu.3_Missense_Mutation_p.R1093S|CACNA1D_uc003dgy.3_Missense_Mutation_p.R1073S|CACNA1D_uc003dgw.3_Missense_Mutation_p.R740S|CACNA1D_uc003dgx.1_Missense_Mutation_p.R221S	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1073	Extracellular (Potential).|III.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TCCTGTGGTCCGTGAACGGAT	0.527													43	42					4.16155e-14	8.75175e-14	1	0	A	53781378	A	A	53781378	3	1	166	1	0	0	0	0	1	0	0	0	2553	652	23	3	3491	3	CACNA1D	3	53781378	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4403949	53781378	144241052	185	30513											
ADAMTS9	56999	broad.mit.edu	37	chr3	64608244	64608244	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccatttagcaagaattcaCctttactgcttgataaagct	12	15	5	9	0	1	2	1	1	0	1	2	2	2	2	2	0	4	3	2	0	6	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:64608244C>T	uc003dmg.2	-	17	2440	c.2408G>A	c.(2407-2409)GGT>GAT	p.G803D	ADAMTS9_uc011bfo.1_Missense_Mutation_p.G775D|ADAMTS9_uc003dmh.1_Missense_Mutation_p.G632D|ADAMTS9_uc003dmk.1_Missense_Mutation_p.G803D	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	803	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CAAGAATTCACCTTTACTGCT	0.388													17	20					0	0	0	0	T	64608244	T	T	64608244	3	4	166	1	0	0	0	0	1	0	0	0	273	507	18	4	3491	4	ADAMTS9	3	64608244	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	10826866	64608244	133414186	186	30514											
GPR27	2850	broad.mit.edu	37	chr3	71804129	71804129	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctacctgcgggtcctggTgcggcccggcgccgtccccc	2	6	14	19	5	0	0	0	0	0	0	2	0	2	0	6	4	4	1	6	4	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:71804129T>A	uc011bge.1	+	1	929	c.929T>A	c.(928-930)GTG>GAG	p.V310E	EIF4E3_uc003dox.2_5'Flank|EIF4E3_uc011bgd.1_5'Flank|EIF4E3_uc010hoc.2_5'Flank	NM_018971	NP_061844	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	310	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		CGGGTCCTGGTGCGGCCCGGC	0.667													10	15					0	0	0	0	A	71804129	A	A	71804129	3	1	166	1	0	0	0	0	1	0	0	0	6723	1696	59	5	931	5	GPR27	3	71804129	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	7195885	71804129	126218301	187	30515											
GXYLT2	727936	broad.mit.edu	37	chr3	73004273	73004273	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttaaaggatgtggactcaCttctctacgtggacaccgat	10	13	9	9	2	2	0	1	0	1	0	3	4	2	3	1	3	1	0	1	3	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:73004273C>A	uc003dpg.2	+	4	625	c.625C>A	c.(625-627)CTT>ATT	p.L209I		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	209	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						TGTGGACTCACTTCTCTACGT	0.468													13	15					5.50884e-06	9.56361e-06	1	0	A	73004273	A	A	73004273	3	1	166	1	0	0	0	0	1	0	0	0	6943	565	20	4	639	4	GXYLT2	3	73004273	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1200144	73004273	125018157	188	30516											
PDZRN3	23024	broad.mit.edu	37	chr3	73433878	73433878	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagggcaggtcgccgctgccCaaggtgtcctggctgcaggt	6	7	16	12	2	0	0	0	0	0	0	2	0	1	0	3	5	2	4	3	5	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:73433878C>A	uc003dpl.1	-	10	1935	c.1839G>T	c.(1837-1839)TTG>TTT	p.L613F	PDZRN3_uc011bgh.1_Missense_Mutation_p.L270F|PDZRN3_uc010hoe.1_Missense_Mutation_p.L311F|PDZRN3_uc011bgf.1_Missense_Mutation_p.L330F|PDZRN3_uc011bgg.1_Missense_Mutation_p.L333F	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	613							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CGCCGCTGCCCAAGGTGTCCT	0.647													25	36					3.01185e-09	5.68711e-09	1	0	A	73433878	A	A	73433878	3	1	166	1	0	0	0	0	1	0	0	0	11763	593	21	4	1365	4	PDZRN3	3	73433878	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	429605	73433878	124588552	189	30517											
POU1F1	5449	broad.mit.edu	37	chr3	87313582	87313582	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcagctgtggggtcctctgCcagaagaggctggtgtatag	8	9	16	8	0	1	2	0	0	1	2	2	2	2	2	2	4	3	4	2	4	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:87313582C>A	uc003dqq.1	-	3	420	c.295G>T	c.(295-297)GCA>TCA	p.A99S	POU1F1_uc010hoj.1_Missense_Mutation_p.A125S	NM_000306	NP_000297	P28069	PIT1_HUMAN	pituitary specific transcription factor 1	99					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|skin(1)	2	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		GGGTCCTCTGCCAGAAGAGGC	0.438													39	36					6.2361e-21	1.46908e-20	1	0	A	87313582	A	A	87313582	3	1	166	1	0	0	0	0	1	0	0	0	12324	739	26	4	596	4	POU1F1	3	87313582	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	13879704	87313582	110708848	190	30518											
EPHA3	2042	broad.mit.edu	37	chr3	89391052	89391052	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtggaatataaaacagtGtgagccatgcagcccaaatg	14	8	12	7	0	0	1	0	1	0	0	0	2	0	2	2	2	4	1	2	2	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:89391052G>T	uc003dqy.2	+	5	1343	c.1118G>T	c.(1117-1119)TGT>TTT	p.C373F	EPHA3_uc003dqx.1_Missense_Mutation_p.C373F|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	373	Extracellular (Potential).|Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATAAAACAGTGTGAGCCATGC	0.493										TSP Lung(6;0.00050)			14	28					1.3612e-06	2.40573e-06	1	0	T	89391052	T	T	89391052	3	4	166	1	0	0	0	0	1	0	0	0	5192	1377	48	4	1136	4	EPHA3	3	89391052	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2077470	89391052	108631378	191	30519											
EPHA6	285220	broad.mit.edu	37	chr3	97454962	97454962	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggtggaggacatccttgTgtaagaggcataatgttgag	10	11	14	6	0	0	2	0	1	0	1	1	4	1	4	2	4	0	3	2	4	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:97454962T>C	uc010how.1	+	16	3171	c.3128T>C	c.(3127-3129)GTA>GCA	p.V1043A	EPHA6_uc003drt.2_Missense_Mutation_p.V435A|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	948	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GACATCCTTGTGTAAGAGGCA	0.383													44	35					0	0	0	0	C	97454962	C	C	97454962	3	2	166	1	0	0	0	0	1	0	0	0	5195	1710	59	5	3307	5	EPHA6	3	97454962	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	8063910	97454962	100567468	192	30520											
OR5H14	403273	broad.mit.edu	37	chr3	97868383	97868383	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgattgctgtcatctggaaaGaccctcatcttcatatccca	10	13	6	12	0	5	2	3	1	2	1	6	3	6	3	2	1	1	1	2	1	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:97868383G>A	uc003dsg.1	+	1	154	c.154G>A	c.(154-156)GAC>AAC	p.D52N		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CATCTGGAAAGACCCTCATCT	0.413													89	425					0	0	0	0	A	97868383	A	A	97868383	3	1	166	1	0	0	0	0	1	0	0	0	11214	942	33	2	156	2	OR5H14	3	97868383	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	413421	97868383	100154047	193	30521											
COL8A1	1295	broad.mit.edu	37	chr3	99513943	99513943	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcctgcctggaatcccaggtCctatgggccctccaggtgct	5	9	12	15	0	0	0	0	0	0	0	3	1	3	1	6	4	2	1	6	4	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:99513943C>A	uc003dtg.1	+	5	1443	c.1198C>A	c.(1198-1200)CCT>ACT	p.P400T	COL8A1_uc003dth.1_Missense_Mutation_p.P400T|COL8A1_uc003dti.1_Missense_Mutation_p.P401T	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	400	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						AATCCCAGGTCCTATGGGCCC	0.612													8	62					0.00307968	0.00498857	1	0	A	99513943	A	A	99513943	3	1	166	1	0	0	0	0	1	0	0	0	3720	855	30	2	1204	2	COL8A1	3	99513943	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1645560	99513943	98508487	194	30522											
MYH15	22989	broad.mit.edu	37	chr3	108211406	108211406	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtagttcctctctccaGcctgctggaaaatcaccctg	7	12	9	13	0	2	0	1	0	1	0	5	1	4	1	4	2	2	3	4	2	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:108211406G>A	uc003dxa.1	-	10	929	c.872C>T	c.(871-873)GCT>GTT	p.A291V		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	291	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CCTCTCTCCAGCCTGCTGGAA	0.368													14	44					0	0	0	0	A	108211406	A	A	108211406	3	1	166	1	0	0	0	0	1	0	0	0	10087	971	34	4	5100	4	MYH15	3	108211406	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	8697463	108211406	89811024	195	30523											
TRAT1	50852	broad.mit.edu	37	chr3	108549617	108549617	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atttcccactatgtggaaaaGcaacgacaaggtaagacatt	16	9	8	8	1	0	1	0	0	0	1	1	3	1	2	1	2	2	2	1	2	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:108549617G>T	uc003dxi.1	+	2	252	c.108G>T	c.(106-108)AAG>AAT	p.K36N	TRAT1_uc010hpx.1_Intron	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	36	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						ATGTGGAAAAGCAACGACAAG	0.418													36	178					6.02846e-25	1.4678e-24	1	0	T	108549617	T	T	108549617	3	4	166	1	0	0	0	0	1	0	0	0	16533	962	34	4	114	4	TRAT1	3	108549617	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	338211	108549617	89472813	196	30524											
TRAT1	50852	broad.mit.edu	37	chr3	108568018	108568018	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttttaattcccaagaaccaAtggatgaaaattgctatgaa	16	13	6	6	0	0	3	0	2	0	1	1	4	1	4	2	1	2	1	2	1	8	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:108568018A>G	uc003dxi.1	+	5	364	c.220A>G	c.(220-222)ATG>GTG	p.M74V	TRAT1_uc010hpx.1_Missense_Mutation_p.M37V	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	74	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						CCAAGAACCAATGGATGAAAA	0.338													15	71					0	0	0	0	G	108568018	G	G	108568018	3	3	166	1	0	0	0	0	1	0	0	0	16533	101	4	5	238	5	TRAT1	3	108568018	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	18401	108568018	89454412	197	30525											
ADPRH	141	broad.mit.edu	37	chr3	119301305	119301305	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatggaagacatggatgggCgggcaccaggtgagcacagc	11	4	17	9	1	0	2	0	1	0	1	0	4	0	4	1	5	2	3	1	5	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:119301305C>A	uc003ecs.2	+	3	587	c.289C>A	c.(289-291)CGG>AGG	p.R97R	ADPRH_uc010hqv.2_Silent_p.R97R|ADPRH_uc011bjb.1_Intron|ADPRH_uc003ect.2_Silent_p.R97R	NM_001125	NP_001116	P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	97					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			ovary(1)	1		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		CATGGATGGGCGGGCACCAGG	0.473													14	84					9.7654e-05	0.000163452	1	0	A	119301305	A	A	119301305	2	1	166	1	0	0	0	0	0	0	0	1	331	759	27	3		3	ADPRH	3	119301305	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	10733287	119301305	78721125	198	30526											
GTF2E1	2960	broad.mit.edu	37	chr3	120469827	120469827	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagacttagaagctaatcAgctctttgatcctatgacag	13	11	7	10	0	2	4	1	2	1	2	3	4	3	4	1	0	2	2	1	0	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:120469827A>T	uc003edz.3	+	2	542	c.428A>T	c.(427-429)CAG>CTG	p.Q143L	GTF2E1_uc003edy.2_Missense_Mutation_p.Q143L	NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	143	C4-type (Potential).				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		GAAGCTAATCAGCTCTTTGAT	0.353													18	64					0	0	0	0	T	120469827	T	T	120469827	3	4	166	1	0	0	0	0	1	0	0	0	6895	188	7	5	430	5	GTF2E1	3	120469827	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1168522	120469827	77552603	199	30527											
STXBP5L	9515	broad.mit.edu	37	chr3	121001149	121001149	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcctgtctaacttttatcCtgatttaacgaaacggatcc	10	14	7	10	2	1	1	0	1	1	0	3	3	3	2	3	2	3	0	3	2	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:121001149C>A	uc003eec.3	+	20	2287	c.2147C>A	c.(2146-2148)CCT>CAT	p.P716H	STXBP5L_uc011bji.1_Intron	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	716					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AACTTTTATCCTGATTTAACG	0.383													15	54					1.3612e-06	2.40573e-06	1	0	A	121001149	A	A	121001149	3	1	166	1	0	0	0	0	1	0	0	0	15423	681	24	4	2221	4	STXBP5L	3	121001149	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	531322	121001149	77021281	200	30528											
CD86	942	broad.mit.edu	37	chr3	121838297	121838297	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctccagagaaaaaatccaTatacctgaaagatctgatga	17	10	6	8	0	2	5	0	3	2	2	4	6	3	5	3	0	1	0	3	0	6	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:121838297T>C	uc003eet.2	+	7	1022	c.906T>C	c.(904-906)CAT>CAC	p.H302H	CD86_uc011bjo.1_Silent_p.H220H|CD86_uc011bjp.1_Silent_p.H190H|CD86_uc003eeu.2_Silent_p.H296H	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	302	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	AAAAAATCCATATACCTGAAA	0.338													17	57					0	0	0	0	C	121838297	C	C	121838297	2	2	166	1	0	0	0	0	0	0	0	1	3058	1403	49	5		5	CD86	3	121838297	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	837148	121838297	76184133	201	30529											
SEMA5B	54437	broad.mit.edu	37	chr3	122642512	122642512	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gggagccaggcagccctgggGttctcctggtagcgaaatgg	7	7	17	10	1	1	0	0	0	1	0	2	2	1	1	3	6	3	3	3	6	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:122642512G>T	uc003efz.1	-	10	1528	c.1224C>A	c.(1222-1224)AAC>AAA	p.N408K	SEMA5B_uc011bju.1_Missense_Mutation_p.N350K|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.N408K|SEMA5B_uc010hro.1_Missense_Mutation_p.N350K|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	408	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CAGCCCTGGGGTTCTCCTGGT	0.557													31	135					1.88708e-17	4.24648e-17	1	0	T	122642512	T	T	122642512	3	4	166	1	0	0	0	0	1	0	0	0	14103	1252	44	4	2287	4	SEMA5B	3	122642512	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	804215	122642512	75379918	202	30530											
MYLK	4638	broad.mit.edu	37	chr3	123427705	123427705	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctgactcttggatctcattCccattgtgcagccagatgac	8	13	8	12	0	3	3	1	2	3	1	5	4	4	4	2	1	2	1	2	1	0	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:123427705C>A	uc003ego.2	-	15	2262	c.1980G>T	c.(1978-1980)GGG>GGT	p.G660G	MYLK_uc011bjw.1_Silent_p.G660G|MYLK_uc003egp.2_Silent_p.G591G|MYLK_uc003egq.2_Silent_p.G660G|MYLK_uc003egr.2_Silent_p.G591G|MYLK_uc003egs.2_Silent_p.G484G	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	660	Ig-like C2-type 5.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GGATCTCATTCCCATTGTGCA	0.562													22	127					9.95505e-16	2.17282e-15	1	0	A	123427705	A	A	123427705	2	1	166	1	0	0	0	0	0	0	0	1	10109	842	30	2		2	MYLK	3	123427705	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	785193	123427705	74594725	203	30531											
CCDC14	64770	broad.mit.edu	37	chr3	123633847	123633847	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacaacctgatgggccatGacatgcagtttgttcctctg	10	11	10	10	0	1	3	0	2	1	1	2	3	2	3	3	1	2	3	3	1	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:123633847G>T	uc011bjx.1	-	13	2732	c.2641C>A	c.(2641-2643)CAT>AAT	p.H881N	CCDC14_uc003egv.3_Missense_Mutation_p.H522N|CCDC14_uc003egx.3_Missense_Mutation_p.H681N|CCDC14_uc010hrt.2_Missense_Mutation_p.H840N|CCDC14_uc003egy.3_Missense_Mutation_p.H681N|CCDC14_uc003egz.2_3'UTR	NM_022757	NP_073594	Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	881						centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		GATGGGCCATGACATGCAGTT	0.458													18	89					3.41278e-10	6.62939e-10	1	0	T	123633847	T	T	123633847	3	4	166	1	0	0	0	0	1	0	0	0	2785	1290	45	2	224	2	CCDC14	3	123633847	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	206142	123633847	74388583	204	30532											
KALRN	8997	broad.mit.edu	37	chr3	124377324	124377324	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtattgtcagaataagccgcGctcagagtacatcgttgctg	10	11	11	9	3	2	2	2	0	0	2	3	2	2	2	1	0	3	5	1	0	4	5	rs144160219	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:124377324G>T	uc003ehg.2	+	42	6207	c.6080G>T	c.(6079-6081)CGC>CTC	p.R2027L	KALRN_uc003ehi.2_Missense_Mutation_p.R368L|KALRN_uc003ehk.2_Missense_Mutation_p.R330L|KALRN_uc011bjz.1_Missense_Mutation_p.R119L	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2026	DH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AATAAGCCGCGCTCAGAGTAC	0.507													24	99					1.17739e-12	2.38644e-12	1	0	T	124377324	T	T	124377324	3	4	166	1	0	0	0	0	1	0	0	0	8014	1087	38	3	6402	3	KALRN	3	124377324	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	743477	124377324	73645106	205	30533											
ALDH1L1	10840	broad.mit.edu	37	chr3	125879696	125879696	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctccattggctcactcacCcagggggtcggcctttccat	5	11	10	15	1	2	0	2	0	0	0	5	0	4	0	4	4	1	2	4	4	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:125879696C>A	uc003eim.1	-	2	317	c.127G>T	c.(127-129)GGT>TGT	p.G43C	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.G43C|ALDH1L1_uc010hsf.1_Missense_Mutation_p.W7C|ALDH1L1_uc003eip.1_5'Flank|ALDH1L1_uc011bkj.1_5'UTR	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	43	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GCTCACTCACCCAGGGGGTCG	0.602													28	162					9.39395e-14	1.95666e-13	1	0	A	125879696	A	A	125879696	3	1	166	1	0	0	0	0	1	0	0	0	494	637	22	4	2669	4	ALDH1L1	3	125879696	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1502372	125879696	72142734	206	30534											
UROC1	131669	broad.mit.edu	37	chr3	126218903	126218903	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcctccttcctcctacctgCtctctgggcctccaagagga	5	11	7	18	0	1	1	0	0	1	1	7	2	6	2	7	2	2	1	7	2	2	2	rs142723755	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:126218903C>A	uc003eiz.1	-	12	1272	c.1240G>T	c.(1240-1242)GCA>TCA	p.A414S	UROC1_uc010hsi.1_Missense_Mutation_p.A474S	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	414					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		ctcctACCTGCTCTCTGGGCC	0.532													15	64					2.23348e-06	3.91909e-06	1	0	A	126218903	A	A	126218903	3	1	166	1	0	0	0	0	1	0	0	0	17096	797	28	4	826	4	UROC1	3	126218903	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	339207	126218903	71803527	207	30535											
TXNRD3IT1	645840	broad.mit.edu	37	chr3	126291216	126291216	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcttccaggggactgggaaaCccctgtccaaaaaccttgtc	10	9	9	13	0	1	0	0	0	1	0	4	2	3	2	5	3	2	0	5	3	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:126291216C>A	uc003ejc.2	-	3	650	c.171G>T	c.(169-171)GGG>GGT	p.G57G		NM_001039783	NP_001034872	Q6F5E7	TR3N_HUMAN	thioredoxin reductase 3 intronic transcript 1	57											0						GACTGGGAAACCCCTGTCCAA	0.393													22	90					0.00278032	0.00451112	1	0	A	126291216	A	A	126291216	2	1	166	1	0	0	0	0	0	0	0	1	16877	494	18	4		4	TXNRD3IT1	3	126291216	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	72313	126291216	71731214	208	30536											
EEFSEC	60678	broad.mit.edu	37	chr3	128060074	128060074	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcttgcttactccccatcAggtggtgaagaaggtgaagt	9	12	11	9	0	2	3	1	2	1	1	4	3	3	3	2	3	2	1	2	3	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:128060074A>T	uc003eki.2	+	5	825	c.787_splice	c.e5-2	p.V263_splice	EEFSEC_uc003ekj.2_Splice_Site_p.V208_splice	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,							cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						ACTCCCCATCAGGTGGTGAAG	0.562													26	100					0	0	0	0	T	128060074	T	T	128060074	5	4	166	1	0	0	0	0	0	0	1	0	4953	202	7	5	803	5	EEFSEC	3	128060074	Splice_Site	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1768858	128060074	69962356	209	30537											
RAB7A	7879	broad.mit.edu	37	chr3	128516832	128516832	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatgtgaataagaaattcAgcaatcagtacaaagccaca	19	8	7	7	0	2	2	2	1	0	1	2	2	2	2	1	0	3	3	1	0	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:128516832A>C	uc003eks.1	+	3	332	c.100A>C	c.(100-102)AGC>CGC	p.S34R	RAB7A_uc010hsv.1_Missense_Mutation_p.S34R|RAB7A_uc003ekt.2_Missense_Mutation_p.S10R	NM_004637	NP_004628	P51149	RAB7A_HUMAN	RAB7, member RAS oncogene family	34					endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding				0				GBM - Glioblastoma multiforme(114;0.231)		TAAGAAATTCAGCAATCAGTA	0.433													30	109					0	0	0	0	C	128516832	C	C	128516832	3	2	166	1	0	0	0	0	1	0	0	0	13019	188	7	5	106	5	RAB7A	3	128516832	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	456758	128516832	69505598	210	30538											
GP9	2815	broad.mit.edu	37	chr3	128780893	128780893	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctggctggaggaccgcaCgcccgaggccctgctgcagg	5	5	15	16	3	1	0	0	0	1	0	1	3	1	2	4	5	2	4	4	5	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:128780893C>G	uc003elm.2	+	3	498	c.311C>G	c.(310-312)ACG>AGG	p.T104R		NM_000174	NP_000165	P14770	GPIX_HUMAN	glycoprotein IX (platelet) precursor	104	LRRCT.|Extracellular (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding				0					Quinine(DB00468)	GAGGACCGCACGCCCGAGGCC	0.692													15	64					0	0	0	0	G	128780893	G	G	128780893	3	3	166	1	0	0	0	0	1	0	0	0	6623	536	19	3	313	3	GP9	3	128780893	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	264061	128780893	69241537	211	30539											
PIK3R4	30849	broad.mit.edu	37	chr3	130442379	130442379	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcatcactaagaccttgttgCagcagaggcttgagaattga	12	10	11	8	0	1	4	1	2	0	3	1	5	1	4	1	1	2	5	1	1	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:130442379C>G	uc003enj.2	-	7	2441	c.1860G>C	c.(1858-1860)CTG>CTC	p.L620L		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	620					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						GACCTTGTTGCAGCAGAGGCT	0.408													29	36					0	0	0	0	G	130442379	G	G	130442379	2	3	166	1	0	0	0	0	0	0	0	1	11976	697	25	4		4	PIK3R4	3	130442379	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1661486	130442379	67580051	212	30540											
ATP2C1	27032	broad.mit.edu	37	chr3	130683850	130683850	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacgaagaatgaaatgacTgttactcacatatttacttc	14	13	6	8	1	1	4	1	3	0	1	2	5	1	4	0	0	2	1	0	0	6	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:130683850T>A	uc003enl.2	+	14	1305	c.1083T>A	c.(1081-1083)ACT>ACA	p.T361T	ATP2C1_uc011blg.1_Silent_p.T395T|ATP2C1_uc011blh.1_Silent_p.T356T|ATP2C1_uc011bli.1_Silent_p.T395T|ATP2C1_uc003enk.2_Silent_p.T345T|ATP2C1_uc003enm.2_Silent_p.T361T|ATP2C1_uc003enn.2_Silent_p.T345T|ATP2C1_uc003eno.2_Silent_p.T361T|ATP2C1_uc003enp.2_Silent_p.T361T|ATP2C1_uc003enq.2_Silent_p.T361T|ATP2C1_uc003enr.2_Silent_p.T361T|ATP2C1_uc003ens.2_Silent_p.T361T|ATP2C1_uc003ent.2_Silent_p.T361T|ATP2C1_uc003enu.2_Silent_p.T39T	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	361	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	ATGAAATGACTGTTACTCACA	0.333									Hailey-Hailey_disease				55	43					0	0	0	0	A	130683850	A	A	130683850	2	1	166	1	0	0	0	0	0	0	0	1	1145	1567	55	5		5	ATP2C1	3	130683850	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	241471	130683850	67338580	213	30541											
CPNE4	131034	broad.mit.edu	37	chr3	131624228	131624228	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcaactttggtcaggcagggGctgttaaagattcccagtgt	9	12	12	8	0	2	1	2	0	0	1	3	1	3	1	1	4	1	3	1	4	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:131624228G>T	uc003eok.2	-	2	495	c.60C>A	c.(58-60)AGC>AGA	p.S20R	CPNE4_uc011blq.1_Missense_Mutation_p.S38R|CPNE4_uc003eol.2_Missense_Mutation_p.S38R|CPNE4_uc003eom.2_Missense_Mutation_p.S20R	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	20										upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCAGGCAGGGGCTGTTAAAGA	0.458													18	57					1.67942e-08	3.12895e-08	1	0	T	131624228	T	T	131624228	3	4	166	1	0	0	0	0	1	0	0	0	3829	1194	42	4	1673	4	CPNE4	3	131624228	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	940378	131624228	66398202	214	30542											
SLCO2A1	6578	broad.mit.edu	37	chr3	133672524	133672524	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacctgtgttgaccctgccaTagtccacaaagatctgcagc	10	9	8	14	0	1	2	0	1	1	1	2	2	2	2	4	0	3	2	4	0	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:133672524T>A	uc003eqa.3	-	5	981	c.707A>T	c.(706-708)TAT>TTT	p.Y236F	SLCO2A1_uc003eqb.3_Missense_Mutation_p.Y160F|SLCO2A1_uc011blv.1_Intron|SLCO2A1_uc010htw.1_Missense_Mutation_p.Y68F	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	236	Helical; Name=5; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						GACCCTGCCATAGTCCACAAA	0.522													64	58					0	0	0	0	A	133672524	A	A	133672524	3	1	166	1	0	0	0	0	1	0	0	0	14790	1406	49	5	1264	5	SLCO2A1	3	133672524	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2048296	133672524	64349906	215	30543											
ESYT3	83850	broad.mit.edu	37	chr3	138174129	138174129	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgagagaagagcatccacCtgaggacctttacctttacc	11	9	8	13	1	0	3	0	1	0	2	2	6	2	4	6	1	3	1	6	1	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:138174129C>A	uc003esk.2	+	3	689	c.463C>A	c.(463-465)CTG>ATG	p.L155M	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	155						integral to membrane|plasma membrane					0						GAGCATCCACCTGAGGACCTT	0.522													19	105					1.15919e-05	1.99649e-05	1	0	A	138174129	A	A	138174129	3	1	166	1	0	0	0	0	1	0	0	0	5290	680	24	4	473	4	ESYT3	3	138174129	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4501605	138174129	59848301	216	30544											
ZBTB38	253461	broad.mit.edu	37	chr3	141163889	141163889	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccagaacccagtggagacAgcccactcgggctttgccaa	11	5	10	15	1	0	2	0	0	0	2	1	3	0	2	4	2	3	1	4	2	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:141163889A>T	uc003etw.2	+	8	3641	c.2659A>T	c.(2659-2661)AGC>TGC	p.S887C	ZBTB38_uc010hun.2_Missense_Mutation_p.S884C|ZBTB38_uc010huo.2_Missense_Mutation_p.S887C|ZBTB38_uc003ety.2_Missense_Mutation_p.S887C|ZBTB38_uc010hup.2_Missense_Mutation_p.S888C	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	887					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CAGTGGAGACAGCCCACTCGG	0.507													19	65					0	0	0	0	T	141163889	T	T	141163889	3	4	166	1	0	0	0	0	1	0	0	0	17606	188	7	5	2661	5	ZBTB38	3	141163889	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2989760	141163889	56858541	217	30545											
XRN1	54464	broad.mit.edu	37	chr3	142030457	142030457	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgagatatactatggccttGagaggcagtttcaacttgaa	12	12	11	6	0	1	3	1	3	0	2	1	5	1	3	1	2	2	2	1	2	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:142030457G>C	uc003eus.2	-	42	5084	c.5017C>G	c.(5017-5019)CAA>GAA	p.Q1673E	XRN1_uc010huu.2_Missense_Mutation_p.Q1127E|XRN1_uc003eut.2_Missense_Mutation_p.Q1660E|XRN1_uc003euu.2_Missense_Mutation_p.Q1661E	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1673					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						CTATGGCCTTGAGAGGCAGTT	0.403													30	170					0	0	0	0	C	142030457	C	C	142030457	3	2	166	1	0	0	0	0	1	0	0	0	17527	1299	45	2	107	2	XRN1	3	142030457	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	866568	142030457	55991973	218	30546											
SLC9A9	285195	broad.mit.edu	37	chr3	143292939	143292939	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagcactgacctgttaggcCggcagcctcggcagacagga	10	5	14	12	2	0	2	0	1	0	1	1	4	0	3	3	4	2	4	3	4	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:143292939C>A	uc003evn.2	-	8	1173	c.991G>T	c.(991-993)GGC>TGC	p.G331C		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	331	Helical; (Potential).				regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						CCTGTTAGGCCGGCAGCCTCG	0.537													9	66					0.000274275	0.000453271	1	0	A	143292939	A	A	143292939	3	1	166	1	0	0	0	0	1	0	0	0	14785	652	23	3	982	3	SLC9A9	3	143292939	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1262482	143292939	54729491	219	30547											
PLSCR4	57088	broad.mit.edu	37	chr3	145938675	145938675	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggttttgtttgattttccatTtcacctgcaggctgttcagg	5	18	10	8	0	2	1	2	1	0	0	3	1	3	1	2	3	1	5	2	3	0	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:145938675T>G	uc010huy.2	-	3	374	c.45A>C	c.(43-45)GAA>GAC	p.E15D	PLSCR4_uc010huz.2_Missense_Mutation_p.E15D|PLSCR4_uc003evt.3_Missense_Mutation_p.E15D|PLSCR4_uc010hva.2_Missense_Mutation_p.E15D|PLSCR4_uc003evu.3_5'UTR	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	15	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						GATTTTCCATTTCACCTGCAG	0.393													11	33					0	0	0	0	G	145938675	G	G	145938675	3	3	166	1	0	0	0	0	1	0	0	0	12167	1838	64	5	972	5	PLSCR4	3	145938675	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2645736	145938675	52083755	220	30548											
CPA3	1359	broad.mit.edu	37	chr3	148596303	148596303	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatatcccaggcaggcacagCtacgcaaaatacaataattg	16	7	8	10	1	0	0	0	0	0	0	1	1	1	0	1	2	3	4	1	2	7	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:148596303C>A	uc003ewm.2	+	4	397	c.345C>A	c.(343-345)AGC>AGA	p.S115R		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	115					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			GCAGGCACAGCTACGCAAAAT	0.313													67	39					3.05417e-18	6.94452e-18	1	0	A	148596303	A	A	148596303	3	1	166	1	0	0	0	0	1	0	0	0	3806	796	28	4	359	4	CPA3	3	148596303	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2657628	148596303	49426127	221	30549											
PLCH1	23007	broad.mit.edu	37	chr3	155303945	155303945	+	Frame_Shift_Del	DEL	C	-	-																															caatattcagcaagccgtcaCcattcttatcagcttcctca																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:155303945delC	uc011bok.1	-	4	750	c.473delG	c.(472-474)GGTfs	p.G158fs	PLCH1_uc011boj.1_Frame_Shift_Del_p.G158fs|PLCH1_uc011bol.1_Frame_Shift_Del_p.G140fs	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	158	Potential.|EF-hand 1.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CAAGCCGTCACCATTCTTATC	0.403													---	---	---								-	155303945	-	-	155303945	7	5	166	1	0	1	0	1	0	0	0	0	12092	507	18	0	4703	0	PLCH1	3	155303945	Frame_Shift_Del	DEL	C	TCGA-CR-7402-01A-11D-2012-08	6707642	155303945	42718485	222	30550											
VEPH1	79674	broad.mit.edu	37	chr3	157146130	157146130	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctcgagttgttttttctttGctgctacatgcaaaagccgt	7	16	8	10	2	1	0	0	0	1	0	2	1	1	0	2	0	5	5	2	0	3	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:157146130G>C	uc003fbj.1	-	5	994	c.677C>G	c.(676-678)GCA>GGA	p.A226G	VEPH1_uc003fbk.1_Missense_Mutation_p.A226G|VEPH1_uc010hvu.1_Missense_Mutation_p.A226G	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	226						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TTTTTTCTTTGCTGCTACATG	0.438													14	89					0	0	0	0	C	157146130	C	C	157146130	3	2	166	1	0	0	0	0	1	0	0	0	17222	1319	46	4	1864	4	VEPH1	3	157146130	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1842185	157146130	40876300	223	30551											
SCHIP1	29970	broad.mit.edu	37	chr3	159583964	159583964	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattttaggcacagaaaaatGagagagagtctatcagacag	18	8	10	5	0	2	4	1	1	1	4	2	6	2	4	0	1	0	1	0	1	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:159583964G>A	uc003fcs.1	+	3	838	c.772G>A	c.(772-774)GAG>AAG	p.E258K	SCHIP1_uc003fcq.1_Missense_Mutation_p.E334K|SCHIP1_uc003fcr.1_Missense_Mutation_p.E247K|SCHIP1_uc003fct.1_Missense_Mutation_p.E245K|SCHIP1_uc010hvz.1_Missense_Mutation_p.E218K|SCHIP1_uc003fcu.1_Missense_Mutation_p.E15K|SCHIP1_uc003fcv.1_Missense_Mutation_p.E31K	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	258						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			ACAGAAAAATGAGAGAGAGTC	0.403													27	141					0	0	0	0	A	159583964	A	A	159583964	3	1	166	1	0	0	0	0	1	0	0	0	13969	1291	45	2	782	2	SCHIP1	3	159583964	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2437834	159583964	38438466	224	30552											
SI	6476	broad.mit.edu	37	chr3	164741509	164741509	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcgagctgagttgactgaaTaagagttatcttgtctggga	11	12	13	5	1	2	4	0	3	2	1	2	6	2	5	0	1	2	3	0	1	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:164741509T>A	uc003fei.2	-	26	3010	c.2948A>T	c.(2947-2949)TAT>TTT	p.Y983F		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	983	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTTGACTGAATAAGAGTTATC	0.403										HNSCC(35;0.089)			10	47					0	0	0	0	A	164741509	A	A	164741509	3	1	166	1	0	0	0	0	1	0	0	0	14362	1406	49	5	2627	5	SI	3	164741509	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5157545	164741509	33280921	225	30553											
MECOM	2122	broad.mit.edu	37	chr3	168806817	168806817	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggactttctgtgtaacggctGcttaagttcctctggcacat	7	14	10	10	1	2	0	0	0	2	0	3	1	3	1	1	3	2	5	1	3	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:168806817G>T	uc003ffi.3	-	15	3261	c.2992C>A	c.(2992-2994)CAG>AAG	p.Q998K	MECOM_uc010hwk.1_Missense_Mutation_p.Q1012K|MECOM_uc003ffj.3_Missense_Mutation_p.Q1063K|MECOM_uc011bpi.1_Missense_Mutation_p.Q990K|MECOM_uc003ffn.3_Missense_Mutation_p.Q998K|MECOM_uc003ffk.2_Missense_Mutation_p.Q989K|MECOM_uc003ffl.2_Missense_Mutation_p.Q1149K|MECOM_uc011bpj.1_Missense_Mutation_p.Q1186K|MECOM_uc011bpk.1_Missense_Mutation_p.Q988K	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	998					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TGTAACGGCTGCTTAAGTTCC	0.393													21	82					4.4004e-07	7.9054e-07	1	0	T	168806817	T	T	168806817	3	4	166	1	0	0	0	0	1	0	0	0	9475	1328	46	4	171	4	MECOM	3	168806817	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4065308	168806817	29215613	226	30554											
TNIK	23043	broad.mit.edu	37	chr3	170781743	170781743	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcctccagatcgcacggatGcaaaaaatacctgtttgaaa	14	10	7	10	2	0	2	0	1	0	1	3	3	2	3	3	1	2	3	3	1	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:170781743G>T	uc003fhh.2	-	33	4355	c.4010C>A	c.(4009-4011)GCA>GAA	p.A1337E	TNIK_uc003fhi.2_Missense_Mutation_p.A1282E|TNIK_uc003fhj.2_Missense_Mutation_p.A1308E|TNIK_uc003fhk.2_Missense_Mutation_p.A1329E|TNIK_uc003fhl.2_Missense_Mutation_p.A1253E|TNIK_uc003fhm.2_Missense_Mutation_p.A1274E|TNIK_uc003fhn.2_Missense_Mutation_p.A1300E|TNIK_uc003fho.2_Missense_Mutation_p.A1245E|TNIK_uc003fhg.2_Missense_Mutation_p.A515E	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1337					actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCGCACGGATGCAAAAAATAC	0.403													52	40					6.81593e-30	1.68677e-29	1	0	T	170781743	T	T	170781743	3	4	166	1	0	0	0	0	1	0	0	0	16379	1319	46	4	76	4	TNIK	3	170781743	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1974926	170781743	27240687	227	30555											
TNIK	23043	broad.mit.edu	37	chr3	170805171	170805171	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggaatgggttgagacgCgccccagtccctcagtcggg	6	7	15	13	3	1	1	1	1	0	1	3	3	2	2	4	3	0	1	4	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:170805171C>T	uc003fhh.2	-	24	3191	c.2846G>A	c.(2845-2847)CGC>CAC	p.R949H	TNIK_uc003fhi.2_Missense_Mutation_p.R894H|TNIK_uc003fhj.2_Missense_Mutation_p.R920H|TNIK_uc003fhk.2_Missense_Mutation_p.R941H|TNIK_uc003fhl.2_Missense_Mutation_p.R865H|TNIK_uc003fhm.2_Missense_Mutation_p.R886H|TNIK_uc003fhn.2_Missense_Mutation_p.R912H|TNIK_uc003fho.2_Missense_Mutation_p.R857H|TNIK_uc003fhg.2_Missense_Mutation_p.R127H	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	949	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGTTGAGACGCGCCCCAGTCC	0.582													26	146					0	0	0	0	T	170805171	T	T	170805171	3	4	166	1	0	0	0	0	1	0	0	0	16379	768	27	1	1276	1	TNIK	3	170805171	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	23428	170805171	27217259	228	30556											
FNDC3B	64778	broad.mit.edu	37	chr3	172059019	172059019	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtaccggcggacacagcCaggttggttttgtttccata	8	12	11	10	2	1	0	1	0	0	0	2	1	2	1	3	4	2	4	3	4	2	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:172059019C>T	uc003fhy.2	+	17	2141	c.1969C>T	c.(1969-1971)CAG>TAG	p.Q657*	FNDC3B_uc003fhz.3_Nonsense_Mutation_p.Q657*	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	657	Fibronectin type-III 4.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		CGGACACAGCCAGGTTGGTTT	0.443													160	139					0	0	0	0	T	172059019	T	T	172059019	4	4	166	1	0	0	0	0	0	1	0	0	6002	595	21	4	2031	4	FNDC3B	3	172059019	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1253848	172059019	25963411	229	30557											
SPATA16	83893	broad.mit.edu	37	chr3	172607391	172607392	+	Frame_Shift_Ins	INS	-	T	T																															aacagtttgaagtcgcttcaINStttttgttttttgccttcga																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:172607391_172607392insT	uc003fin.3	-	11	1836_1837	c.1678_1679insA	c.(1678-1680)ATGfs	p.M560fs		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	560					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			AAGTCGCTTCATTTTTGTTTTT	0.401													---	---	---								T	172607392	T	T	172607391	7	5	166	1	0	1	1	0	0	0	0	0	15067	217	8	0	34	0	SPATA16	3	172607391	Frame_Shift_Ins	INS	-	TCGA-CR-7402-01A-11D-2012-08	548372	172607391	25415039	230	30558	61	2									
SPATA16	83893	broad.mit.edu	37	chr3	172607397	172607397	+	Frame_Shift_Del	DEL	G	-	-																															tttgaagtcgcttcatttttGttttttgccttcgagcagtt																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:172607397delG	uc003fin.3	-	11	1831	c.1673delC	c.(1672-1674)ACAfs	p.T558fs		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	558					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			CTTCATTTTTGTTTTTTGCCT	0.388													---	---	---								-	172607397	-	-	172607397	7	5	166	1	0	1	0	1	0	0	0	0	15067	1377	48	0	40	0	SPATA16	3	172607397	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	6	172607397	25415033	231	30559	61	2									
NAALADL2	254827	broad.mit.edu	37	chr3	175184791	175184791	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatatcatagttggcagccAtcatcacactgcacacagtt	12	11	7	11	0	3	0	3	0	0	0	3	0	3	0	1	1	2	5	1	1	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:175184791A>G	uc003fit.2	+	8	1439	c.1352A>G	c.(1351-1353)CAT>CGT	p.H451R	NAALADL2_uc003fiu.1_Missense_Mutation_p.H444R|NAALADL2_uc010hwy.1_Missense_Mutation_p.H225R|NAALADL2_uc010hwz.1_Missense_Mutation_p.H45R	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	451	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		GTTGGCAGCCATCATCACACT	0.363													66	310					0	0	0	0	G	175184791	G	G	175184791	3	3	166	1	0	0	0	0	1	0	0	0	10183	217	8	5	1382	5	NAALADL2	3	175184791	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2577394	175184791	22837639	232	30560											
USP13	8975	broad.mit.edu	37	chr3	179418886	179418886	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccagatcactatgaaatagCactaccaaatattgaggagt	16	9	7	9	0	1	3	1	2	0	1	1	4	1	4	2	1	2	1	2	1	6	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:179418886C>A	uc003fkh.2	+	4	527	c.446C>A	c.(445-447)GCA>GAA	p.A149E	USP13_uc003fkf.2_Missense_Mutation_p.A149E	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	149					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TATGAAATAGCACTACCAAAT	0.443													41	56					4.14481e-20	9.64825e-20	1	0	A	179418886	A	A	179418886	3	1	166	1	0	0	0	0	1	0	0	0	17112	710	25	4	460	4	USP13	3	179418886	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4234095	179418886	18603544	233	30561											
LAMP3	27074	broad.mit.edu	37	chr3	182841971	182841971	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggccccaatcacaggaagCacaattgtgtagtcagacga	14	7	10	10	1	2	1	2	0	0	1	2	3	2	2	2	2	1	2	2	2	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:182841971C>A	uc003flh.3	-	6	1373	c.1149G>T	c.(1147-1149)GTG>GTT	p.V383V		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	383	Helical; (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			TCACAGGAAGCACAATTGTGT	0.423													25	100					1.66031e-10	3.23801e-10	1	0	A	182841971	A	A	182841971	2	1	166	1	0	0	0	0	0	0	0	1	8659	697	25	4		4	LAMP3	3	182841971	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3423085	182841971	15180459	234	30562											
MCF2L2	23101	broad.mit.edu	37	chr3	182924003	182924003	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgaattgaaagtgtcatcagCtattataaagagggaagaga	17	9	11	4	1	2	3	2	1	0	2	2	6	2	4	0	1	1	1	0	1	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:182924003C>A	uc003fli.1	-	24	2803	c.2713_splice	c.e24-1	p.L905_splice		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GTGTCATCAGCTATTATAAAG	0.408													25	133					4.26978e-12	8.53955e-12	1	0	A	182924003	A	A	182924003	5	1	166	1	0	0	0	0	0	0	1	0	9433	811	28	4	660	4	MCF2L2	3	182924003	Splice_Site	SNP	C	TCGA-CR-7402-01A-11D-2012-08	82032	182924003	15098427	235	30563											
YEATS2	55689	broad.mit.edu	37	chr3	183508669	183508669	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcaagtgtgtgtgagccagGccaccgtgggaacctgcaag	10	6	15	10	1	0	1	0	1	0	0	0	2	0	2	4	2	4	2	4	2	3	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:183508669G>A	uc003fly.2	+	21	3193	c.2998G>A	c.(2998-3000)GCC>ACC	p.A1000T	YEATS2_uc003flz.2_Missense_Mutation_p.A79T	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1000					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGTGAGCCAGGCCACCGTGGG	0.597													32	140					0	0	0	0	A	183508669	A	A	183508669	3	1	166	1	0	0	0	0	1	0	0	0	17540	1203	42	4	3076	4	YEATS2	3	183508669	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	584666	183508669	14513761	236	30564											
HTR3E	285242	broad.mit.edu	37	chr3	183823166	183823166	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgggcctcagcaaggccaCcgcaaagttgtccaggggag	9	5	14	13	1	1	0	1	0	0	0	2	1	2	1	5	4	1	3	5	4	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:183823166C>A	uc010hxq.2	+	6	1137	c.671C>A	c.(670-672)ACC>AAC	p.T224N	HTR3E_uc003fml.3_Missense_Mutation_p.T209N|HTR3E_uc003fmm.2_Missense_Mutation_p.T239N|HTR3E_uc010hxr.2_Missense_Mutation_p.T250N|HTR3E_uc003fmn.2_Missense_Mutation_p.T224N	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	224	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGCAAGGCCACCGCAAAGTTG	0.527													17	70					1.15088e-07	2.08863e-07	1	0	A	183823166	A	A	183823166	3	1	166	1	0	0	0	0	1	0	0	0	7487	507	18	4	734	4	HTR3E	3	183823166	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	314497	183823166	14199264	237	30565											
IL1RAP	3556	broad.mit.edu	37	chr3	190326880	190326880	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaactcccagtgcataaactGtatatagaatatggcattca	16	11	6	8	0	1	1	1	0	0	1	2	1	2	1	1	1	3	3	1	1	8	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:190326880G>T	uc003fsm.1	+	5	653	c.447G>T	c.(445-447)CTG>CTT	p.L149L	IL1RAP_uc003fsk.2_Silent_p.L149L|IL1RAP_uc003fsl.2_Silent_p.L149L|IL1RAP_uc010hzf.2_Silent_p.L8L|IL1RAP_uc010hzg.1_Silent_p.L149L|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Silent_p.L149L|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Silent_p.L149L	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	149	Extracellular (Potential).|Ig-like C2-type 2.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		TGCATAAACTGTATATAGAAT	0.388													26	115					1.42536e-11	2.84201e-11	1	0	T	190326880	T	T	190326880	2	4	166	1	0	0	0	0	0	0	0	1	7699	1364	48	4		4	IL1RAP	3	190326880	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	6503714	190326880	7695550	238	30566											
PYDC2	152138	broad.mit.edu	37	chr3	191179206	191179206	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaatcaaacgcatctgtcTgggagagctgatgaacactg	13	9	11	8	1	3	4	1	3	2	1	3	5	3	4	0	1	3	2	0	1	3	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:191179206T>G	uc011bso.1	+	1	255	c.255T>G	c.(253-255)TCT>TCG	p.S85S		NM_001083308	NP_001076777	Q56P42	PYDC2_HUMAN	pyrin domain containing 2	85	DAPIN.					cytoplasm|nucleus					0						CGCATCTGTCTGGGAGAGCTG	0.517													30	180					0	0	0	0	G	191179206	G	G	191179206	2	3	166	1	0	0	0	0	0	0	0	1	12924	1567	55	5		5	PYDC2	3	191179206	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	852326	191179206	6843224	239	30567											
ACAP2	23527	broad.mit.edu	37	chr3	195012437	195012437	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaagcactgcagttacccTgtgtgccctaagacggtggc	9	9	12	11	1	0	2	0	1	0	1	0	2	0	2	2	2	4	3	2	2	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:195012437T>A	uc003fun.3	-	20	2302	c.2061A>T	c.(2059-2061)ACA>ACT	p.T687T		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	687	ANK 2.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						GCAGTTACCCTGTGTGCCCTA	0.403													19	114					0	0	0	0	A	195012437	A	A	195012437	2	1	166	1	0	0	0	0	0	0	0	1	119	1567	55	5		5	ACAP2	3	195012437	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	3833231	195012437	3009993	240	30568											
LMLN	89782	broad.mit.edu	37	chr3	197746225	197746225	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgccgtgtgtaatttgcagaAgttccctaagcctttaccac	9	13	8	11	1	0	1	0	0	0	1	1	1	1	1	4	0	4	3	4	0	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:197746225A>T	uc011buo.1	+	12	1356	c.1334A>T	c.(1333-1335)AAG>ATG	p.K445M	LMLN_uc003fyt.2_Missense_Mutation_p.K430M|LMLN_uc010iar.2_Missense_Mutation_p.K482M|LMLN_uc010ias.2_Missense_Mutation_p.K393M|LMLN_uc003fyu.2_Missense_Mutation_p.K242M	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	445					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		AATTTGCAGAAGTTCCCTAAG	0.468													16	67					0	0	0	0	T	197746225	T	T	197746225	3	4	166	1	0	0	0	0	1	0	0	0	8889	72	3	5	1495	5	LMLN	3	197746225	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2733788	197746225	276205	241	30569											
GAK	2580	broad.mit.edu	37	chr4	860744	860745	+	Frame_Shift_Ins	INS	-	A	A																															tcagaacagaaacacgtaccINSagcggcagggggccctcctc																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:860744_860745insA	uc003gbm.3	-	21	3070_3071	c.2871_2872insT	c.(2869-2874)GCTGCTfs	p.A957fs	GAK_uc003gbn.3_Frame_Shift_Ins_p.A878fs|GAK_uc010ibk.1_3'UTR|GAK_uc010ibi.2_Frame_Shift_Ins_p.A138fs|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Frame_Shift_Ins_p.A821fs	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	957_958					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		AAACACGTACCAGCGGCAGGGG	0.629													---	---	---								A	860745	A	A	860744	7	5	166	1	0	1	1	0	0	0	0	0	6230	608	21	0	1095	0	GAK	4	860744	Frame_Shift_Ins	INS	-	TCGA-CR-7402-01A-11D-2012-08		860744	190293532	242	30570											
NOP14	8602	broad.mit.edu	37	chr4	2958516	2958516	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcttcatttagattgtagAtgctttttttctcatgatgt	8	21	6	6	0	3	3	2	1	2	2	4	3	3	3	0	0	1	2	0	0	2	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:2958516A>G	uc003ggj.1	-	3	425	c.353T>C	c.(352-354)ATC>ACC	p.I118T	C4orf10_uc003ggi.1_Intron|NOP14_uc003ggk.3_Missense_Mutation_p.I118T|NOP14_uc003ggl.2_Missense_Mutation_p.I118T|NOP14_uc010icq.1_RNA	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	118					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						TAGATTGTAGATGCTTTTTTT	0.358													7	40					0	0	0	0	G	2958516	G	G	2958516	3	3	166	1	0	0	0	0	1	0	0	0	10590	333	12	5	2284	5	NOP14	4	2958516	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2097772	2958516	188195760	243	30571											
OTOP1	133060	broad.mit.edu	37	chr4	4199579	4199579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcaggtataccaccaccaCagcaatggtggcggccagca	13	5	10	13	1	1	0	1	0	0	0	1	0	1	0	4	4	3	3	4	4	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:4199579C>T	uc003ghp.1	-	5	1012	c.982G>A	c.(982-984)GTG>ATG	p.V328M		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	328	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACCACCACCACAGCAATGGTG	0.547													24	52					0	0	0	0	T	4199579	T	T	4199579	3	4	166	1	0	0	0	0	1	0	0	0	11359	478	17	4	864	4	OTOP1	4	4199579	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1241063	4199579	186954697	244	30572											
C4orf6	10141	broad.mit.edu	37	chr4	5527953	5527953	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacatacaggaactgcagaCactgcagataaaacagagcc	17	5	8	11	0	0	3	0	0	0	3	0	4	0	4	1	1	7	2	1	1	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:5527953C>T	uc003gii.2	+	2	352	c.177C>T	c.(175-177)GAC>GAT	p.D59D		NM_005750	NP_005741	Q99440	CD006_HUMAN	chromosome 4 open reading frame 6	59					nervous system development						0						GAACTGCAGACACTGCAGATA	0.448													18	51					0	0	0	0	T	5527953	T	T	5527953	2	4	166	1	0	0	0	0	0	0	0	1	2288	477	17	4		4	C4orf6	4	5527953	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1328374	5527953	185626323	245	30573											
JAKMIP1	152789	broad.mit.edu	37	chr4	6107405	6107405	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccatcgaaggccctgcgcGcctcctcgcgcgcctcggtc	3	7	11	20	7	0	0	0	0	0	0	6	1	2	0	5	2	1	0	5	2	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:6107405G>T	uc003giu.3	-	3	695	c.419C>A	c.(418-420)GCG>GAG	p.A140E	JAKMIP1_uc010idb.1_Missense_Mutation_p.A140E|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Missense_Mutation_p.A140E|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Missense_Mutation_p.A140E|JAKMIP1_uc010ide.2_Missense_Mutation_p.A140E	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	140	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						GGCCCTGCGCGCCTCCTCGCG	0.701													5	9					3.59834e-05	6.10098e-05	1	0	T	6107405	T	T	6107405	3	4	166	1	0	0	0	0	1	0	0	0	7979	1087	38	3	2227	3	JAKMIP1	4	6107405	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	579452	6107405	185046871	246	30574											
WFS1	7466	broad.mit.edu	37	chr4	6296916	6296916	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacctgccactgcgtctgaaGgtgagtgaccaagaccccgg	9	6	13	13	2	1	4	0	3	1	1	1	5	1	4	5	2	2	0	5	2	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:6296916G>T	uc003giy.2	+	7	1027	c.861G>T	c.(859-861)AAG>AAT	p.K287N	WFS1_uc003gix.2_Missense_Mutation_p.K287N|WFS1_uc003giz.2_Missense_Mutation_p.K105N	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	287					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		TGCGTCTGAAGGTGAGTGACC	0.657													24	45					3.80469e-20	8.8882e-20	1	0	T	6296916	T	T	6296916	3	4	166	1	0	0	0	0	1	0	0	0	17428	1014	35	4	883	4	WFS1	4	6296916	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	189511	6296916	184857360	247	30575											
BOD1L	259282	broad.mit.edu	37	chr4	13605783	13605783	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtttgccttgagtttttGatttagacttcaacacaagt	9	17	7	8	0	1	3	1	2	0	1	1	3	1	3	2	0	2	2	2	0	3	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:13605783G>T	uc003gmz.1	-	10	2858	c.2741C>A	c.(2740-2742)TCA>TAA	p.S914*	BOD1L_uc010idr.1_Nonsense_Mutation_p.S251*	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	914	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						TTGAGTTTTTGATTTAGACTT	0.383													34	103					4.3181e-19	1.00278e-18	1	0	T	13605783	T	T	13605783	4	4	166	1	0	0	0	0	0	1	0	0	1486	1294	45	2	6482	2	BOD1L	4	13605783	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	7308867	13605783	177548493	248	30576											
CD38	952	broad.mit.edu	37	chr4	15780186	15780186	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccgaggtggcgccagcagtGgagcggtccgggcaccacca	7	3	16	15	4	0	0	0	0	0	0	1	2	1	1	5	5	2	2	5	5	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:15780186G>T	uc011bxc.1	+	1	256	c.149G>T	c.(148-150)TGG>TTG	p.W50L	CD38_uc003goj.1_Missense_Mutation_p.W50L|CD38_uc003gol.1_Missense_Mutation_p.W50L	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	50	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						CGCCAGCAGTGGAGCGGTCCG	0.617													36	84					2.87052e-16	6.34297e-16	1	0	T	15780186	T	T	15780186	3	4	166	1	0	0	0	0	1	0	0	0	3024	1357	47	4	151	4	CD38	4	15780186	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2174403	15780186	175374090	249	30577											
SLIT2	9353	broad.mit.edu	37	chr4	20255599	20255599	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcgtgcccaggaatatccCccgcaacaccgagagactgt	11	5	10	15	3	0	1	0	0	0	1	1	4	1	2	4	1	3	1	4	1	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:20255599C>A	uc003gpr.1	+	1	365	c.161C>A	c.(160-162)CCC>CAC	p.P54H	SLIT2_uc003gps.1_Missense_Mutation_p.P54H	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	54	LRRNT.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AGGAATATCCCCCGCAACACC	0.667													20	65					9.95505e-16	2.17282e-15	1	0	A	20255599	A	A	20255599	3	1	166	1	0	0	0	0	1	0	0	0	14804	623	22	4	163	4	SLIT2	4	20255599	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4475413	20255599	170898677	250	30578											
SLIT2	9353	broad.mit.edu	37	chr4	20568976	20568976	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaatagtgatccagttgaCttttaccgatgcacctgtcc	9	14	8	10	1	0	2	0	2	0	0	2	3	2	2	4	0	2	3	4	0	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:20568976C>T	uc003gpr.1	+	27	3021	c.2817C>T	c.(2815-2817)GAC>GAT	p.D939D	SLIT2_uc003gps.1_Silent_p.D931D	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	939	EGF-like 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ATCCAGTTGACTTTTACCGAT	0.383													32	79					0	0	0	0	T	20568976	T	T	20568976	2	4	166	1	0	0	0	0	0	0	0	1	14804	564	20	4		4	SLIT2	4	20568976	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	313377	20568976	170585300	251	30579											
ZCCHC4	29063	broad.mit.edu	37	chr4	25314461	25314461	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggaatgggtttgaagcCgtggaggcagagggcagcgc	9	6	18	8	2	0	2	0	1	0	1	1	4	1	4	2	5	2	3	2	5	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:25314461C>A	uc003grl.3	+	1	66	c.30C>A	c.(28-30)GCC>GCA	p.A10A		NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	10							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				GGTTTGAAGCCGTGGAGGCAG	0.652											OREG0016141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	108					6.7651e-33	1.68697e-32	1	0	A	25314461	A	A	25314461	2	1	166	1	0	0	0	0	0	0	0	1	17657	639	23	3		3	ZCCHC4	4	25314461	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4745485	25314461	165839815	252	30580											
PCDH7	5099	broad.mit.edu	37	chr4	30725162	30725162	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgaccgggaacatcagacCacatacactttcagagtcaa	14	9	7	11	1	3	3	3	1	0	2	3	4	3	4	2	1	2	0	2	1	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:30725162C>T	uc003gsk.1	+	1	3126	c.2118C>T	c.(2116-2118)ACC>ACT	p.T706T	PCDH7_uc011bxw.1_Silent_p.T659T|PCDH7_uc011bxx.1_Silent_p.T706T	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	706	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						AACATCAGACCACATACACTT	0.443													29	70					0	0	0	0	T	30725162	T	T	30725162	2	4	166	1	0	0	0	0	0	0	0	1	11570	581	21	4		4	PCDH7	4	30725162	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5410701	30725162	160429114	253	30581											
ARAP2	116984	broad.mit.edu	37	chr4	36230489	36230489	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtctgcattagggagcttaCtgagattttctgtgatcaat	10	15	10	6	0	3	2	1	2	2	1	3	4	3	3	0	1	3	2	0	1	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:36230489C>G	uc003gsq.1	-	2	958	c.620G>C	c.(619-621)AGT>ACT	p.S207T	ARAP2_uc003gsr.1_Missense_Mutation_p.S207T	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	207					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AGGGAGCTTACTGAGATTTTC	0.338													25	84					0	0	0	0	G	36230489	G	G	36230489	3	3	166	1	0	0	0	0	1	0	0	0	839	565	20	4	4622	4	ARAP2	4	36230489	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5505327	36230489	154923787	254	30582											
TBC1D1	23216	broad.mit.edu	37	chr4	37903767	37903767	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctgctttctaacgaggtCtcggtggattttggcctgca	6	14	11	10	2	3	0	0	0	3	0	4	2	3	1	1	4	3	2	1	4	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:37903767C>A	uc003gtb.2	+	2	394	c.51C>A	c.(49-51)GTC>GTA	p.V17V	TBC1D1_uc011byd.1_Silent_p.V17V|TBC1D1_uc010ifd.2_Silent_p.V17V	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	17						nucleus	Rab GTPase activator activity			ovary(1)	1						CTAACGAGGTCTCGGTGGATT	0.522													31	73					3.99451e-17	8.92729e-17	1	0	A	37903767	A	A	37903767	2	1	166	1	0	0	0	0	0	0	0	1	15663	900	32	2		2	TBC1D1	4	37903767	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1673278	37903767	153250509	255	30583											
KLB	152831	broad.mit.edu	37	chr4	39408952	39408952	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcacgaatggttccaGtgacagttatatttttctgg	10	13	10	8	1	1	1	0	1	1	0	2	2	2	1	1	2	2	4	1	2	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:39408952G>T	uc003gua.2	+	1	480	c.383G>T	c.(382-384)AGT>ATT	p.S128I	KLB_uc011byj.1_Missense_Mutation_p.S128I	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	128	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						AATGGTTCCAGTGACAGTTAT	0.398													37	113					2.09667e-21	4.96312e-21	1	0	T	39408952	T	T	39408952	3	4	166	1	0	0	0	0	1	0	0	0	8371	1029	36	4	385	4	KLB	4	39408952	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1505185	39408952	151745324	256	30584											
SLC30A9	10463	broad.mit.edu	37	chr4	42022531	42022531	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagttctgcctcaaatccAggtaatttttttaaaaaatg	14	15	6	6	0	2	1	1	1	1	0	3	1	3	1	2	1	1	2	2	1	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:42022531A>T	uc003gwl.2	+	4	579	c.433A>T	c.(433-435)AGT>TGT	p.S145C	SLC30A9_uc011byx.1_5'UTR	NM_006345	NP_006336	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter),	145					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3						CCTCAAATCCAGGTAATTTTT	0.348													30	67					0	0	0	0	T	42022531	T	T	42022531	3	4	166	1	0	0	0	0	1	0	0	0	14626	202	7	5	447	5	SLC30A9	4	42022531	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2613579	42022531	149131745	257	30585											
KCTD8	386617	broad.mit.edu	37	chr4	44450416	44450416	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagctccactacttcagggAagggcgagggtgcgcagggc	8	6	16	11	2	2	0	2	0	0	0	3	2	3	1	1	4	3	2	1	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:44450416A>T	uc003gwu.2	-	1	409	c.125T>A	c.(124-126)TTC>TAC	p.F42Y		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	42						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TACTTCAGGGAAGGGCGAGGG	0.498										HNSCC(17;0.042)			5	24					0	0	0	0	T	44450416	T	T	44450416	3	4	166	1	0	0	0	0	1	0	0	0	8154	246	9	5	1304	5	KCTD8	4	44450416	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2427885	44450416	146703860	258	30586											
LRRC66	339977	broad.mit.edu	37	chr4	52860966	52860966	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcacattgtccttgcttgccCctgagctctcgtcctgcagg	4	13	9	15	1	2	1	1	1	1	0	5	1	4	1	4	1	4	3	4	1	0	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:52860966C>A	uc003gzi.2	-	4	2235	c.2222G>T	c.(2221-2223)GGG>GTG	p.G741V		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	741						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CTTGCTTGCCCCTGAGCTCTC	0.493													37	96					9.62906e-15	2.06037e-14	1	0	A	52860966	A	A	52860966	3	1	166	1	0	0	0	0	1	0	0	0	9068	623	22	4	424	4	LRRC66	4	52860966	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8410550	52860966	138293310	259	30587											
PDGFRA	5156	broad.mit.edu	37	chr4	55139799	55139799	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggagtaccgtggagggccGtgtgactttcgccaaagtgg	8	8	16	9	3	0	1	0	1	0	0	1	3	0	3	3	4	1	1	3	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:55139799G>C	uc003han.3	+	10	1791	c.1460G>C	c.(1459-1461)CGT>CCT	p.R487P	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.R381P|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	487	Ig-like C2-type 5.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTGGAGGGCCGTGTGACTTTC	0.522			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			28	78					0	0	0	0	C	55139799	C	C	55139799	3	2	166	1	0	0	0	0	1	0	0	0	11715	1145	40	3	1494	3	PDGFRA	4	55139799	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2278833	55139799	136014477	260	30588											
KIT	3815	broad.mit.edu	37	chr4	55598063	55598063	+	Frame_Shift_Del	DEL	C	-	-																															acatagaaagagatgtgactCccgccatcatggaggatgac																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:55598063delC	uc010igr.2	+	16	2347	c.2260delC	c.(2260-2262)CCCfs	p.P754fs	KIT_uc010igs.2_Frame_Shift_Del_p.P750fs	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	754	Protein kinase.|Cytoplasmic (Potential).				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGATGTGACTCCCGCCATCAT	0.468		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				---	---	---								-	55598063	-	-	55598063	7	5	166	1	0	1	0	1	0	0	0	0	8368	855	30	0	2322	0	KIT	4	55598063	Frame_Shift_Del	DEL	C	TCGA-CR-7402-01A-11D-2012-08	458264	55598063	135556213	261	30589											
KIT	3815	broad.mit.edu	37	chr4	55604710	55604710	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccagcctctgcttgtgcAcgacgatgtctgagcagaat	8	10	10	13	2	2	2	0	1	2	1	3	4	3	2	2	0	4	3	2	0	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:55604710A>G	uc010igr.2	+	21	3005	c.2918A>G	c.(2917-2919)CAC>CGC	p.H973R	KIT_uc010igs.2_Missense_Mutation_p.H969R	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	973	Cytoplasmic (Potential).				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTGCTTGTGCACGACGATGTC	0.512		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				46	111					0	0	0	0	G	55604710	G	G	55604710	3	3	166	1	0	0	0	0	1	0	0	0	8368	159	6	5	3000	5	KIT	4	55604710	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	6647	55604710	135549566	262	30590											
AASDH	132949	broad.mit.edu	37	chr4	57215852	57215852	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacctagtggaattcagagAcaaaatttgactccctctgc	14	10	7	10	0	2	2	1	1	1	1	3	4	3	3	2	1	2	0	2	1	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:57215852A>T	uc003hbn.2	-	11	2218	c.2065T>A	c.(2065-2067)TCT>ACT	p.S689T	AASDH_uc010ihb.2_Missense_Mutation_p.S204T|AASDH_uc011caa.1_Missense_Mutation_p.S536T|AASDH_uc003hbo.2_Missense_Mutation_p.S589T|AASDH_uc011cab.1_Missense_Mutation_p.S204T|AASDH_uc010ihc.2_Missense_Mutation_p.S689T|AASDH_uc003hbp.2_Missense_Mutation_p.S689T	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	689					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				GAATTCAGAGACAAAATTTGA	0.393													24	79					0	0	0	0	T	57215852	T	T	57215852	3	4	166	1	0	0	0	0	1	0	0	0	22	275	10	5	1251	5	AASDH	4	57215852	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1611142	57215852	133938424	263	30591											
TECRL	253017	broad.mit.edu	37	chr4	65275045	65275045	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctctcttgcgttccgaagCgagggacttgtgccttttga	5	14	12	10	3	1	1	0	1	1	0	3	4	2	2	2	1	4	2	2	1	1	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:65275045C>A	uc003hcv.2	-	1	134	c.25G>T	c.(25-27)GCT>TCT	p.A9S	TECRL_uc003hcw.2_Missense_Mutation_p.A9S	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	9					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						CGTTCCGAAGCGAGGGACTTG	0.393													25	57					4.59853e-10	8.90624e-10	1	0	A	65275045	A	A	65275045	3	1	166	1	0	0	0	0	1	0	0	0	15812	768	27	3	1114	3	TECRL	4	65275045	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8059193	65275045	125879231	264	30592											
EPHA5	2044	broad.mit.edu	37	chr4	66356139	66356139	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagacacatactgccgggctCctgggctcaagtcggacact	9	7	11	14	2	1	1	1	0	0	1	3	2	2	2	2	3	2	2	2	3	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:66356139C>G	uc003hcy.2	-	5	1551	c.1358G>C	c.(1357-1359)GGA>GCA	p.G453A	EPHA5_uc003hcx.2_Missense_Mutation_p.G384A|EPHA5_uc003hcz.2_Missense_Mutation_p.G453A|EPHA5_uc011cah.1_Missense_Mutation_p.G453A|EPHA5_uc011cai.1_Missense_Mutation_p.G453A|EPHA5_uc003hda.2_Missense_Mutation_p.G453A	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	453	Fibronectin type-III 1.|Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CTGCCGGGCTCCTGGGCTCAA	0.468										TSP Lung(17;0.13)			21	58					0	0	0	0	G	66356139	G	G	66356139	3	3	166	1	0	0	0	0	1	0	0	0	5194	855	30	2	1811	2	EPHA5	4	66356139	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1081094	66356139	124798137	265	30593											
TMPRSS11F	389208	broad.mit.edu	37	chr4	68919756	68919756	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgtaccagatgtcatgattAtcataaaccagaggtccacc	14	10	7	10	0	2	3	2	1	0	2	3	3	3	3	4	1	2	1	4	1	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:68919756A>T	uc003hdt.1	-	10	1237	c.1188T>A	c.(1186-1188)GAT>GAA	p.D396E	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	396	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TGTCATGATTATCATAAACCA	0.368													16	45					0	0	0	0	T	68919756	T	T	68919756	3	4	166	1	0	0	0	0	1	0	0	0	16309	446	16	5	132	5	TMPRSS11F	4	68919756	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2563617	68919756	122234520	266	30594											
UGT2B11	10720	broad.mit.edu	37	chr4	70080161	70080161	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatgtctgaccatctcttaaCctgttgcatgatgatattct	10	16	6	9	0	3	3	0	3	3	0	4	3	3	3	2	0	2	2	2	0	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:70080161C>A	uc003heh.2	-	1	289	c.280G>T	c.(280-282)GTT>TTT	p.V94F	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	94					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						CATCTCTTAACCTGTTGCATG	0.313													48	118					4.64027e-19	1.07632e-18	1	0	A	70080161	A	A	70080161	3	1	166	1	0	0	0	0	1	0	0	0	17025	507	18	4	1333	4	UGT2B11	4	70080161	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1160405	70080161	121074115	267	30595											
CSN2	1447	broad.mit.edu	37	chr4	70823471	70823471	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gataggttcaacgaatggatAgatcagaggctgtggctgga	12	9	15	5	1	2	2	2	0	0	2	2	6	2	4	0	5	1	3	0	5	4	3	rs139725489		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:70823471A>T	uc003hes.3	-	5	209	c.196T>A	c.(196-198)TAT>AAT	p.Y66N	CSN2_uc003het.3_Missense_Mutation_p.Y65N	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	66					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						ACGAATGGATAGATCAGAGGC	0.443													21	56					0	0	0	0	T	70823471	T	T	70823471	3	4	166	1	0	0	0	0	1	0	0	0	3965	420	15	5	492	5	CSN2	4	70823471	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	743310	70823471	120330805	268	30596											
ADAMTS3	9508	broad.mit.edu	37	chr4	73205293	73205293	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtcatccactcccagcagtAcctcgatattgtaatcgttt	10	13	6	12	2	1	0	1	0	0	0	5	1	3	0	3	0	2	4	3	0	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:73205293A>T	uc003hgk.1	-	5	816	c.779T>A	c.(778-780)GTA>GAA	p.V260E		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	260	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCCCAGCAGTACCTCGATATT	0.478													84	239					0	0	0	0	T	73205293	T	T	73205293	3	4	166	1	0	0	0	0	1	0	0	0	267	391	14	5	2910	5	ADAMTS3	4	73205293	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2381822	73205293	117948983	269	30597											
AFP	174	broad.mit.edu	37	chr4	74318195	74318195	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtgttggccagtgctgcacTtcttcatatgccaacaggag	8	11	12	10	0	2	0	1	0	1	0	2	1	2	1	2	3	4	3	2	3	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:74318195T>A	uc003hgz.1	+	12	1553	c.1506T>A	c.(1504-1506)ACT>ACA	p.T502T	AFP_uc003hha.1_Silent_p.T502T|AFP_uc011cbg.1_Silent_p.T276T	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	502	Albumin 3.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGTGCTGCACTTCTTCATATG	0.443									Alpha-Fetoprotein_Hereditary_Persistence_of				27	76					0	0	0	0	A	74318195	A	A	74318195	2	1	166	1	0	0	0	0	0	0	0	1	363	1596	56	5		5	AFP	4	74318195	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1112902	74318195	116836081	270	30598											
HERC5	51191	broad.mit.edu	37	chr4	89407376	89407377	+	Missense_Mutation	DNP	TG	CT	CT																															aggtacttgtggaaaatgacTgtggtaggtatagcatgttt																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:89407376_89407377TG>CT	uc003hrt.2	+	14	2001_2002	c.1848_1849TG>CT	c.(1846-1851)ACTGTG>ACCTTG	p.V617L	HERC5_uc011cdm.1_Missense_Mutation_p.V255L	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	617					innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity	p.T616T(1)		ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		GGAAAATGACTGTGGTAGGTAT	0.312													13	32					0	0	0	0	CT	89407377	CT	CT	89407376	3	2	166	1	0	0	0	0	1	0	0	0	7100	1567	55	5	1902	5	HERC5	4	89407376	Missense_Mutation	DNP	TG	TCGA-CR-7402-01A-11D-2012-08	15089181	89407376	101746900	271	30599											
GRID2	2895	broad.mit.edu	37	chr4	94006343	94006343	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	actacactctctcagttcgcCcacctgtctacttgcatgat	8	13	5	15	1	3	1	1	1	2	0	5	1	3	1	2	0	3	2	2	0	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:94006343C>A	uc011cdt.1	+	3	700	c.442C>A	c.(442-444)CCA>ACA	p.P148T	GRID2_uc010ikx.2_Missense_Mutation_p.P148T|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	148	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTCAGTTCGCCCACCTGTCTA	0.478													29	77					7.26314e-15	1.55582e-14	1	0	A	94006343	A	A	94006343	3	1	166	1	0	0	0	0	1	0	0	0	6811	623	22	4	452	4	GRID2	4	94006343	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4598967	94006343	97147933	272	30600											
PDHA2	5161	broad.mit.edu	37	chr4	96761796	96761796	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgggggcaatggcatcgtCggtgcacagggccccctggg	6	7	17	11	2	0	0	0	0	0	0	2	0	0	0	2	6	1	3	2	6	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:96761796C>A	uc003htr.3	+	1	558	c.495C>A	c.(493-495)GTC>GTA	p.V165V		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	165					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	ATGGCATCGTCGGTGCACAGG	0.507													26	69					3.28513e-13	6.7352e-13	1	0	A	96761796	A	A	96761796	2	1	166	1	0	0	0	0	0	0	0	1	11719	871	31	3		3	PDHA2	4	96761796	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2755453	96761796	94392480	273	30601											
BANK1	55024	broad.mit.edu	37	chr4	102951361	102951361	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attataaatagacctcctgcCcccacaccccgacccacaag	13	6	4	18	1	0	1	0	0	0	1	1	2	1	1	7	0	1	0	7	0	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:102951361C>A	uc003hvy.3	+	10	2113	c.1839C>A	c.(1837-1839)GCC>GCA	p.A613A	BANK1_uc003hvx.3_Silent_p.A598A|BANK1_uc010ill.2_Silent_p.A480A|BANK1_uc003hvz.3_Silent_p.A583A	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	613					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		GACCTCCTGCCCCCACACCCC	0.373													25	48					6.32553e-13	1.29012e-12	1	0	A	102951361	A	A	102951361	2	1	166	1	0	0	0	0	0	0	0	1	1311	610	22	4		4	BANK1	4	102951361	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	6189565	102951361	88202915	274	30602											
LEF1	51176	broad.mit.edu	37	chr4	109088901	109088901	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtcccccccgccgccgccaCctcctccggagagttggggc	3	5	13	20	4	0	1	0	0	0	1	3	2	3	1	9	4	0	1	9	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:109088901C>T	uc003hyt.1	-	1	678	c.23G>A	c.(22-24)GGT>GAT	p.G8D	LEF1_uc011cfj.1_5'Flank|LEF1_uc011cfk.1_5'Flank|LEF1_uc003hyu.1_Missense_Mutation_p.G8D|LEF1_uc003hyv.1_Missense_Mutation_p.G8D|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	8	Poly-Gly.|CTNNB1-binding (By similarity).				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		GCCGCCGCCACCTCCTCCGGA	0.642													33	83					0	0	0	0	T	109088901	T	T	109088901	3	4	166	1	0	0	0	0	1	0	0	0	8754	507	18	4	1317	4	LEF1	4	109088901	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	6137540	109088901	82065375	275	30603											
ENPEP	2028	broad.mit.edu	37	chr4	111470910	111470910	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcttctggtgtatcggtatgGgatgcagaactctggcaatg	8	12	14	7	1	2	1	0	0	2	1	3	2	2	2	0	4	2	5	0	4	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:111470910G>T	uc003iab.3	+	17	2711	c.2369G>T	c.(2368-2370)GGG>GTG	p.G790V		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	790	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TATCGGTATGGGATGCAGAAC	0.388													16	62					1.99824e-07	3.61638e-07	1	0	T	111470910	T	T	111470910	3	4	166	1	0	0	0	0	1	0	0	0	5152	1232	43	4	2435	4	ENPEP	4	111470910	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2382009	111470910	79683366	276	30604											
ANK2	287	broad.mit.edu	37	chr4	114274328	114274328	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caagatttgatcaaaatgacCgccatcttgaccacagatgt	14	10	7	10	1	2	5	1	3	1	2	2	5	2	5	3	0	0	0	3	0	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:114274328C>A	uc003ibe.3	+	38	4654	c.4554C>A	c.(4552-4554)ACC>ACA	p.T1518T	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Silent_p.T1533T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1485					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCAAAATGACCGCCATCTTGA	0.458													26	70					9.39395e-14	1.95666e-13	1	0	A	114274328	A	A	114274328	2	1	166	1	0	0	0	0	0	0	0	1	621	639	23	3		3	ANK2	4	114274328	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2803418	114274328	76879948	277	30605											
C4orf31	79625	broad.mit.edu	37	chr4	121958113	121958113	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gctcgactgtcttctgtttgGcttcttccttggtcctggca	2	17	10	12	1	3	0	0	0	3	0	6	1	5	0	2	3	0	4	2	3	0	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:121958113G>C	uc003idq.1	-	4	1540	c.1013C>G	c.(1012-1014)GCC>GGC	p.A338G		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	338											0						CTTCTGTTTGGCTTCTTCCTT	0.438													22	71					0	0	0	0	C	121958113	C	C	121958113	3	2	166	1	0	0	0	0	1	0	0	0	2271	1203	42	4	697	4	C4orf31	4	121958113	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	7683785	121958113	69196163	278	30606											
INPP4B	8821	broad.mit.edu	37	chr4	142950038	142950038	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actttctgcatttgatattcTtcagtacattctctatgcgg	8	18	6	9	1	4	1	1	1	3	0	5	1	4	1	0	1	3	2	0	1	3	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:142950038T>C	uc003iix.3	-	27	3267	c.2672A>G	c.(2671-2673)AAG>AGG	p.K891R	INPP4B_uc003iiw.3_Missense_Mutation_p.K891R|INPP4B_uc011chm.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	891					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					TTTGATATTCTTCAGTACATT	0.393													11	31					0	0	0	0	C	142950038	C	C	142950038	3	2	166	1	0	0	0	0	1	0	0	0	7792	1609	56	5	106	5	INPP4B	4	142950038	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	20991925	142950038	48204238	279	30607											
INPP4B	8821	broad.mit.edu	37	chr4	143235901	143235901	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggatccttatgttctggtagGacactggttcgaacctgtgg	7	13	13	8	1	1	0	0	0	1	0	3	3	2	2	2	5	1	3	2	5	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:143235901G>T	uc003iix.3	-	9	982	c.387C>A	c.(385-387)GTC>GTA	p.V129V	INPP4B_uc003iiw.3_Silent_p.V129V|INPP4B_uc011chm.1_RNA|INPP4B_uc011cho.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	129	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					GTTCTGGTAGGACACTGGTTC	0.433													36	99					9.17885e-22	2.18597e-21	1	0	T	143235901	T	T	143235901	2	4	166	1	0	0	0	0	0	0	0	1	7792	1161	41	2		2	INPP4B	4	143235901	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	285863	143235901	47918375	280	30608											
GYPB	2994	broad.mit.edu	37	chr4	144920591	144920591	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaaacgatggacaagttGtcccgtttctcctataaagc	12	11	9	9	2	1	1	0	1	1	0	3	3	2	2	2	1	2	2	2	1	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:144920591G>T	uc003ijm.1	-	3	204	c.148C>A	c.(148-150)CAA>AAA	p.Q50K	GYPA_uc003ijn.2_Intron|GYPB_uc011chs.1_RNA|GYPB_uc011cht.1_RNA|GYPB_uc011chu.1_RNA|GYPB_uc010ioo.1_RNA|GYPB_uc010iop.2_RNA|GYPB_uc011chv.1_RNA|GYPB_uc011chw.1_RNA|GYPB_uc011chx.1_Intron|GYPB_uc011chy.1_RNA|GYPB_uc011chz.1_RNA	NM_002100	NP_002091	P06028	GLPB_HUMAN	glycophorin B precursor	50	Extracellular (Potential).					integral to plasma membrane					0	all_hematologic(180;0.158)					TGGACAAGTTGTCCCGTTTCT	0.328													4	11					0.00024832	0.000412114	1	0	T	144920591	T	T	144920591	3	4	166	1	0	0	0	0	1	0	0	0	6948	1386	48	4	139	4	GYPB	4	144920591	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1684690	144920591	46233685	281	30609											
GYPA	2993	broad.mit.edu	37	chr4	145035886	145035886	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaggcacgtctgtgtcaGgtgaggggagaggttttaca	10	11	15	5	1	2	2	1	1	1	1	2	3	2	2	0	5	1	2	0	5	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:145035886G>T	uc003ijo.3	-	6	508	c.392C>A	c.(391-393)CCT>CAT	p.P131H	GYPA_uc003ijn.2_Intron|GYPA_uc011cia.1_RNA|GYPA_uc011cib.1_Missense_Mutation_p.P98H|GYPA_uc003ijp.3_Missense_Mutation_p.P99H|GYPA_uc010ioq.2_Missense_Mutation_p.P118H|GYPA_uc010ior.2_Missense_Mutation_p.P66H|GYPA_uc010ios.1_RNA	NM_002099	NP_002090	P02724	GLPA_HUMAN	glycophorin A precursor	131	Cytoplasmic.				interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)	2	all_hematologic(180;0.15)					GTCTGTGTCAGGTGAGGGGAG	0.328													13	31					7.93312e-07	1.41354e-06	1	0	T	145035886	T	T	145035886	3	4	166	1	0	0	0	0	1	0	0	0	6947	1000	35	4	68	4	GYPA	4	145035886	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	115295	145035886	46118390	282	30610											
KIAA0922	23240	broad.mit.edu	37	chr4	154525579	154525579	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaaatttccaggaaaaatAatggtaatcttttcatcccc	15	12	5	9	0	2	1	1	0	1	1	4	2	4	2	3	2	0	1	3	2	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:154525579A>T	uc003inm.3	+	25	3464	c.3412A>T	c.(3412-3414)AAT>TAT	p.N1138Y	KIAA0922_uc010ipp.2_Missense_Mutation_p.N1139Y|KIAA0922_uc010ipq.2_Missense_Mutation_p.N907Y	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1138	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CAGGAAAAATAATGGTAATCT	0.403													9	33					0	0	0	0	T	154525579	T	T	154525579	3	4	166	1	0	0	0	0	1	0	0	0	8240	362	13	5	3513	5	KIAA0922	4	154525579	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	9489693	154525579	36628697	283	30611											
DCHS2	54798	broad.mit.edu	37	chr4	155163899	155163899	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attagaaagcctgggcatccCtttatctgtggcttggacaa	10	12	10	9	0	1	1	0	0	1	1	2	2	2	2	2	3	1	2	2	3	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:155163899C>A	uc003inw.2	-	22	5602	c.5602G>T	c.(5602-5604)GGG>TGG	p.G1868W		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1868	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CTGGGCATCCCTTTATCTGTG	0.383													14	28					1.5739e-10	3.07255e-10	1	0	A	155163899	A	A	155163899	3	1	166	1	0	0	0	0	1	0	0	0	4305	681	24	4	3164	4	DCHS2	4	155163899	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	638320	155163899	35990377	284	30612											
FGA	2243	broad.mit.edu	37	chr4	155505381	155505381	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctcaatctcataaggactGttattccttgggtcatagga	10	15	8	8	0	3	0	3	0	2	0	6	2	4	2	1	3	0	1	1	3	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:155505381G>C	uc003iod.1	-	6	2554	c.2496C>G	c.(2494-2496)AAC>AAG	p.N832K		NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	832	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CATAAGGACTGTTATTCCTTG	0.498													34	100					0	0	0	0	C	155505381	C	C	155505381	3	2	166	1	0	0	0	0	1	0	0	0	5862	1368	48	4	108	4	FGA	4	155505381	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	341482	155505381	35648895	285	30613											
LRAT	9227	broad.mit.edu	37	chr4	155665738	155665738	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgacagacgacatggggcGcacgcagaaggtggtctcca	10	5	14	12	3	1	3	0	1	1	2	2	4	1	3	2	4	0	2	2	4	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:155665738G>T	uc003iom.1	+	1	587	c.260G>T	c.(259-261)CGC>CTC	p.R87L	uc003iol.2_Intron|LRAT_uc003ion.1_Missense_Mutation_p.R87L	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	87	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	GACATGGGGCGCACGCAGAAG	0.597													20	51					1.56452e-12	3.16131e-12	1	0	T	155665738	T	T	155665738	3	4	166	1	0	0	0	0	1	0	0	0	8980	1087	38	3	262	3	LRAT	4	155665738	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	160357	155665738	35488538	286	30614											
GUCY1B3	2983	broad.mit.edu	37	chr4	156696131	156696131	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttccagaaaagaggcacAgttagatgaagaaggacagt	16	8	12	5	0	0	5	0	1	0	4	1	6	1	6	1	2	0	3	1	2	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:156696131A>T	uc003ipc.2	+	3	256	c.89A>T	c.(88-90)CAG>CTG	p.Q30L	GUCY1B3_uc011cio.1_Missense_Mutation_p.Q30L|GUCY1B3_uc011cip.1_Missense_Mutation_p.Q10L|GUCY1B3_uc003ipd.2_5'UTR|GUCY1B3_uc010iqf.2_Missense_Mutation_p.Q30L|GUCY1B3_uc010iqg.2_5'UTR|GUCY1B3_uc011ciq.1_5'UTR	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	30					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AAAGAGGCACAGTTAGATGAA	0.318													41	92					0	0	0	0	T	156696131	T	T	156696131	3	4	166	1	0	0	0	0	1	0	0	0	6934	188	7	5	99	5	GUCY1B3	4	156696131	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1030393	156696131	34458145	287	30615											
GRIA2	2891	broad.mit.edu	37	chr4	158256999	158256999	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatgcagacacgaaaatttgGaatgggatggttggagaact	14	9	14	4	1	0	2	0	0	0	2	0	7	0	4	0	4	2	2	0	4	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:158256999G>T	uc003ipm.3	+	10	1902	c.1443G>T	c.(1441-1443)TGG>TGT	p.W481C	GRIA2_uc011cit.1_Missense_Mutation_p.W434C|GRIA2_uc003ipl.3_Missense_Mutation_p.W481C|GRIA2_uc003ipk.3_Missense_Mutation_p.W434C|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	481	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CGAAAATTTGGAATGGGATGG	0.433													5	11					1.024e-07	1.87399e-07	1	0	T	158256999	T	T	158256999	3	4	166	1	0	0	0	0	1	0	0	0	6807	1183	41	2	1481	2	GRIA2	4	158256999	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1560868	158256999	32897277	288	30616											
TKTL2	84076	broad.mit.edu	37	chr4	164394427	164394427	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaggattcgccatctcccaTaaggcagaacacccggtagc	11	7	10	13	2	1	2	0	1	1	1	3	3	1	3	3	3	2	2	3	3	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:164394427T>C	uc003iqp.3	-	1	621	c.460A>G	c.(460-462)ATG>GTG	p.M154V		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	154						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCATCTCCCATAAGGCAGAAC	0.542													30	80					0	0	0	0	C	164394427	C	C	164394427	3	2	166	1	0	0	0	0	1	0	0	0	16002	1406	49	5	1424	5	TKTL2	4	164394427	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	6137428	164394427	26759849	289	30617											
GALNTL6	442117	broad.mit.edu	37	chr4	173873316	173873316	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgcgcaagcagctcaaGtgcaaggacttcaaatggtt	12	8	12	9	1	2	0	2	0	0	0	2	2	2	1	0	2	5	6	0	2	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:173873316G>T	uc003isv.2	+	10	2014	c.1278G>T	c.(1276-1278)AAG>AAT	p.K426N		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	426	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						AGCAGCTCAAGTGCAAGGACT	0.597													15	37					2.31682e-05	3.94524e-05	1	0	T	173873316	T	T	173873316	3	4	166	1	0	0	0	0	1	0	0	0	6260	1020	36	4	1312	4	GALNTL6	4	173873316	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	9478889	173873316	17280960	290	30618											
WWC2	80014	broad.mit.edu	37	chr4	184186193	184186193	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggggagaaaaccacttgtGtgtcggctgctgtgtctgat	7	13	14	7	1	1	2	0	1	1	1	2	3	1	2	1	3	2	2	1	3	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:184186193G>T	uc010irx.2	+	12	2154	c.1972G>T	c.(1972-1974)GTG>TTG	p.V658L	WWC2_uc003ivk.3_Missense_Mutation_p.V453L|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Missense_Mutation_p.V340L|WWC2_uc003ivn.3_Missense_Mutation_p.V173L|WWC2_uc010irz.2_5'Flank	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	658										ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		AACCACTTGTGTGTCGGCTGC	0.483													15	24					1.52009e-12	3.07787e-12	1	0	T	184186193	T	T	184186193	3	4	166	1	0	0	0	0	1	0	0	0	17480	1377	48	4	2018	4	WWC2	4	184186193	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	10312877	184186193	6968083	291	30619											
SORBS2	8470	broad.mit.edu	37	chr4	186533086	186533086	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggttcctgggattttacCttcataccagttttgatcaa	8	17	8	8	0	2	1	2	1	0	0	3	2	3	2	3	2	2	3	3	2	3	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:186533086C>T	uc003iyl.2	-	18	3790	c.2932G>A	c.(2932-2934)GGT>AGT	p.G978S	SORBS2_uc003iyh.2_Missense_Mutation_p.G702S|SORBS2_uc011ckw.1_Missense_Mutation_p.G539S|SORBS2_uc003iyi.2_Missense_Mutation_p.G609S|SORBS2_uc011ckx.1_Missense_Mutation_p.G544S|SORBS2_uc003iyk.2_Missense_Mutation_p.G522S|SORBS2_uc003iym.2_Missense_Mutation_p.G1078S|SORBS2_uc003iyn.1_Missense_Mutation_p.G569S|SORBS2_uc011cku.1_Missense_Mutation_p.G370S|SORBS2_uc011ckv.1_Missense_Mutation_p.G882S|SORBS2_uc003iyd.2_Missense_Mutation_p.G677S|SORBS2_uc003iye.2_Missense_Mutation_p.G551S|SORBS2_uc003iya.2_Missense_Mutation_p.G498S|SORBS2_uc003iyb.2_Missense_Mutation_p.G451S|SORBS2_uc003iyc.2_Missense_Mutation_p.G431S|SORBS2_uc003iyg.2_Missense_Mutation_p.G1092S|SORBS2_uc003iyf.2_Missense_Mutation_p.G514S|SORBS2_uc003iyo.1_Missense_Mutation_p.G427S	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	978	SH3 2.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GGGATTTTACCTTCATACCAG	0.398													9	41					0	0	0	0	T	186533086	T	T	186533086	3	4	166	1	0	0	0	0	1	0	0	0	14992	681	24	4	386	4	SORBS2	4	186533086	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2346893	186533086	4621190	292	30620											
ZFP42	132625	broad.mit.edu	37	chr4	188924241	188924241	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaggactcactttttgagTccttggaatacctaaagaaa	15	11	8	7	0	1	3	1	1	0	2	2	5	2	5	2	2	1	0	2	2	6	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:188924241T>A	uc003izg.1	+	3	525	c.280T>A	c.(280-282)TCC>ACC	p.S94T	ZFP42_uc003izh.1_Missense_Mutation_p.S94T|ZFP42_uc003izi.1_Missense_Mutation_p.S94T	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	94					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		ACTTTTTGAGTCCTTGGAATA	0.428													34	58					0	0	0	0	A	188924241	A	A	188924241	3	1	166	1	0	0	0	0	1	0	0	0	17717	1667	58	5	282	5	ZFP42	4	188924241	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2391155	188924241	2230035	293	30621											
TRIML2	205860	broad.mit.edu	37	chr4	189018271	189018271	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggcataaactcaggtctGtgatatgagcgggctccaga	10	10	13	8	1	2	3	1	2	1	1	3	3	3	3	1	3	2	2	1	3	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:189018271G>T	uc003izl.2	-	6	575	c.539C>A	c.(538-540)ACA>AAA	p.T180K	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Missense_Mutation_p.T255K	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	180							ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		ACTCAGGTCTGTGATATGAGC	0.498													31	95					4.74835e-14	9.96443e-14	1	0	T	189018271	T	T	189018271	3	4	166	1	0	0	0	0	1	0	0	0	16618	1377	48	4	632	4	TRIML2	4	189018271	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	94030	189018271	2136005	294	30622											
TRIML1	339976	broad.mit.edu	37	chr4	189060957	189060957	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcatcgccaggcagctccGgtcccaggtgctgcagagcg	7	5	14	15	3	0	1	0	0	0	1	3	1	2	1	3	3	5	5	3	3	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:189060957G>T	uc003izm.1	+	1	360	c.245G>T	c.(244-246)CGG>CTG	p.R82L		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	82					multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AGGCAGCTCCGGTCCCAGGTG	0.637													18	48					6.94344e-10	1.34213e-09	1	0	T	189060957	T	T	189060957	3	4	166	1	0	0	0	0	1	0	0	0	16617	1116	39	3	247	3	TRIML1	4	189060957	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	42686	189060957	2093319	295	30623											
ADCY2	108	broad.mit.edu	37	chr5	7789793	7789793	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttagacttcttatggaagaaCaaattcaaaaaagagcggga	18	9	9	5	1	2	3	1	0	1	3	2	5	2	5	0	2	2	0	0	2	8	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:7789793C>A	uc003jdz.1	+	20	2575	c.2508C>A	c.(2506-2508)AAC>AAA	p.N836K	ADCY2_uc011cmo.1_Missense_Mutation_p.N656K|ADCY2_uc010itm.1_Missense_Mutation_p.N32K	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	836	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TATGGAAGAACAAATTCAAAA	0.483													26	93					2.12542e-12	4.29023e-12	1	0	A	7789793	A	A	7789793	3	1	166	1	0	0	0	0	1	0	0	0	294	477	17	4	2586	4	ADCY2	5	7789793	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08		7789793	173125467	296	30624											
DNAH5	1767	broad.mit.edu	37	chr5	13788868	13788868	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaatccacaaaatatgtGtcaattccacaatccaccaa	19	8	3	11	0	1	1	1	0	0	1	4	1	4	1	4	0	0	0	4	0	8	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:13788868G>T	uc003jfd.2	-	51	8646	c.8604C>A	c.(8602-8604)GAC>GAA	p.D2868E		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2868					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CAAAATATGTGTCAATTCCAC	0.413									Kartagener_syndrome				26	83					2.44723e-14	5.18548e-14	1	0	T	13788868	T	T	13788868	3	4	166	1	0	0	0	0	1	0	0	0	4626	1368	48	4	5386	4	DNAH5	5	13788868	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5999075	13788868	167126392	297	30625											
DNAH5	1767	broad.mit.edu	37	chr5	13864714	13864714	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggtccaaaaaagcctgcCagtccttcaaggcccgggga	11	6	11	13	1	2	0	2	0	0	0	4	1	4	1	5	4	2	0	5	4	4	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:13864714C>A	uc003jfd.2	-	28	4430	c.4388G>T	c.(4387-4389)TGG>TTG	p.W1463L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1463	Potential.|Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAAAGCCTGCCAGTCCTTCAA	0.507									Kartagener_syndrome				23	51					9.95505e-16	2.17282e-15	1	0	A	13864714	A	A	13864714	3	1	166	1	0	0	0	0	1	0	0	0	4626	595	21	4	9694	4	DNAH5	5	13864714	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	75846	13864714	167050546	298	30626											
TRIO	7204	broad.mit.edu	37	chr5	14488346	14488346	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcggccagcgagcagtccGtgcagtccacccagagcaac	9	4	11	17	3	0	1	0	0	0	1	3	2	2	1	5	1	5	3	5	1	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:14488346G>T	uc003jff.2	+	48	7615	c.7609G>T	c.(7609-7611)GTG>TTG	p.V2537L	TRIO_uc003jfg.2_Intron|TRIO_uc003jfh.1_Missense_Mutation_p.V2186L	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2537					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CGAGCAGTCCGTGCAGTCCAC	0.721													7	14					8.12818e-05	0.000136164	1	0	T	14488346	T	T	14488346	3	4	166	1	0	0	0	0	1	0	0	0	16619	1145	40	3	7799	3	TRIO	5	14488346	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	623632	14488346	166426914	299	30627											
CDH10	1008	broad.mit.edu	37	chr5	24537561	24537561	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctcattgtcattgatatCatgaattttgatcacaaact	12	16	6	7	0	4	3	4	3	0	0	4	3	4	3	0	1	1	1	0	1	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:24537561C>A	uc003jgr.1	-	3	786	c.454G>T	c.(454-456)GAT>TAT	p.D152Y	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	152	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCATTGATATCATGAATTTTG	0.413										HNSCC(23;0.051)			45	100					2.24893e-16	4.99197e-16	1	0	A	24537561	A	A	24537561	3	1	166	1	0	0	0	0	1	0	0	0	3111	826	29	2	1952	2	CDH10	5	24537561	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	10049215	24537561	156377699	300	30628											
CDH6	1004	broad.mit.edu	37	chr5	31323216	31323216	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggttaaaggaaaatgacaCggaccccactgccccgccat	14	5	9	13	2	0	1	0	1	0	0	0	3	0	3	5	3	1	1	5	3	5	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:31323216C>A	uc003jhe.1	+	12	2500	c.2174C>A	c.(2173-2175)ACG>AAG	p.T725K		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	725	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						GAAAATGACACGGACCCCACT	0.562													13	35					0.00010058	0.000168205	1	0	A	31323216	A	A	31323216	3	1	166	1	0	0	0	0	1	0	0	0	3129	536	19	3	2216	3	CDH6	5	31323216	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	6785655	31323216	149592044	301	30629											
TARS	6897	broad.mit.edu	37	chr5	33457373	33457373	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttttcagaattcctccacGtactgggaaggcaaagcaga	12	10	10	9	1	1	2	1	0	0	2	3	3	3	3	2	2	2	4	2	2	4	4	rs113811412		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:33457373G>A	uc003jhy.2	+	9	1144	c.849G>A	c.(847-849)ACG>ACA	p.T283T	TARS_uc011cob.1_Silent_p.T271T|TARS_uc010iup.1_Silent_p.T224T|TARS_uc011coc.1_Silent_p.T304T|TARS_uc003jhz.2_Silent_p.T179T|TARS_uc011cod.1_Silent_p.T162T	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	283					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	ATTCCTCCACGTACTGGGAAG	0.388													11	38					0	0	0	0	A	33457373	A	A	33457373	2	1	166	1	0	0	0	0	0	0	0	1	15625	1132	40	1		1	TARS	5	33457373	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2134157	33457373	147457887	302	30630											
ADAMTS12	81792	broad.mit.edu	37	chr5	33643537	33643537	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcgtccagcttagagcgacaAaagcccttcacggagcacca	12	5	10	14	3	1	1	1	0	0	1	2	3	2	2	3	1	4	2	3	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:33643537A>G	uc003jia.1	-	10	1681	c.1518T>C	c.(1516-1518)TTT>TTC	p.F506F	ADAMTS12_uc010iuq.1_Silent_p.F506F	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	506	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TAGAGCGACAAAAGCCCTTCA	0.498										HNSCC(64;0.19)			28	79					0	0	0	0	G	33643537	G	G	33643537	2	3	166	1	0	0	0	0	0	0	0	1	257	11	1	5		5	ADAMTS12	5	33643537	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	186164	33643537	147271723	303	30631											
UGT3A1	133688	broad.mit.edu	37	chr5	35991303	35991303	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagagcaggaccccagaaaGaaggaaggccactagaagca	17	2	13	9	0	0	4	0	1	0	4	0	7	0	6	3	3	2	2	3	3	5	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:35991303G>T	uc003jjv.1	-	1	197	c.40C>A	c.(40-42)CTT>ATT	p.L14I	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.L14I|UGT3A1_uc011cor.1_Missense_Mutation_p.L14I|UGT3A1_uc003jjy.1_Intron	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	14						integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACCCCAGAAAGAAGGAAGGCC	0.612													33	79					6.00712e-18	1.36115e-17	1	0	T	35991303	T	T	35991303	3	4	166	1	0	0	0	0	1	0	0	0	17031	942	33	2	1641	2	UGT3A1	5	35991303	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2347766	35991303	144923957	304	30632											
RANBP3L	202151	broad.mit.edu	37	chr5	36260950	36260950	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttttaaaagaacatttatCttcatttggttgacatctaa	13	17	5	6	0	3	2	1	1	2	1	3	2	3	2	0	1	1	2	0	1	5	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:36260950C>T	uc003jkh.2	-	8	1094	c.601G>A	c.(601-603)GAT>AAT	p.D201N	RANBP3L_uc011cow.1_Missense_Mutation_p.D226N	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	201					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			GAACATTTATCTTCATTTGGT	0.249													3	10					0	0	0	0	T	36260950	T	T	36260950	3	4	166	1	0	0	0	0	1	0	0	0	13095	913	32	2	824	2	RANBP3L	5	36260950	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	269647	36260950	144654310	305	30633											
C5orf42	65250	broad.mit.edu	37	chr5	37181062	37181062	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgatttgctctccctctCaatattgggtccaatctgac	8	15	6	12	0	4	2	1	2	4	0	7	2	5	2	2	1	1	1	2	1	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:37181062C>A	uc011cpa.1	-	27	5698	c.5467G>T	c.(5467-5469)GAG>TAG	p.E1823*	C5orf42_uc011coy.1_Nonsense_Mutation_p.E324*|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Nonsense_Mutation_p.E898*	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1823										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CTCTCCCTCTCAATATTGGGT	0.388													9	33					4.68919e-08	8.62987e-08	1	0	A	37181062	A	A	37181062	4	1	166	1	0	0	0	0	0	1	0	0	2311	835	29	2	4230	2	C5orf42	5	37181062	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	920112	37181062	143734198	306	30634											
EGFLAM	133584	broad.mit.edu	37	chr5	38438424	38438424	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaagcatgacttcacctcCggagtgaatgtggagaatgc	11	9	13	8	1	1	4	1	3	0	1	2	6	2	5	2	2	2	1	2	2	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:38438424C>T	uc003jlc.1	+	17	2655	c.2331C>T	c.(2329-2331)TCC>TCT	p.S777S	EGFLAM_uc003jlb.1_Silent_p.S777S|EGFLAM_uc003jle.1_Silent_p.S543S|EGFLAM_uc003jlf.1_Silent_p.S143S	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	777	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					ACTTCACCTCCGGAGTGAATG	0.512													15	43					0	0	0	0	T	38438424	T	T	38438424	2	4	166	1	0	0	0	0	0	0	0	1	4988	639	23	1		1	EGFLAM	5	38438424	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1257362	38438424	142476836	307	30635											
C9	735	broad.mit.edu	37	chr5	39342218	39342218	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgagacaaggatcgcatTgtgaccattcactccagggg	10	9	12	10	1	2	2	1	2	1	1	4	4	3	3	2	3	0	1	2	3	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:39342218T>A	uc003jlv.3	-	2	247	c.158A>T	c.(157-159)CAA>CTA	p.Q53L		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	53	TSP type-1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			AGGATCGCATTGTGACCATTC	0.463													15	66					0	0	0	0	A	39342218	A	A	39342218	3	1	166	1	0	0	0	0	1	0	0	0	2455	1812	63	5	1561	5	C9	5	39342218	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	903794	39342218	141573042	308	30636											
SLC38A9	153129	broad.mit.edu	37	chr5	54945036	54945036	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttgccaaaaagctcaccTggtacaaaaaattctgttgg	14	12	7	8	0	2	0	1	0	1	0	2	0	2	0	2	2	3	3	2	2	6	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:54945036T>C	uc003jqf.2	-	11	1260	c.1059A>G	c.(1057-1059)CCA>CCG	p.P353P	SLC38A9_uc003jqd.2_Silent_p.P290P|SLC38A9_uc010ivx.2_Intron|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Silent_p.P224P	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	353					amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				AAAGCTCACCTGGTACAAAAA	0.303													6	12					0	0	0	0	C	54945036	C	C	54945036	2	2	166	1	0	0	0	0	0	0	0	1	14675	1594	55	5		5	SLC38A9	5	54945036	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	15602818	54945036	125970224	309	30637											
BDP1	55814	broad.mit.edu	37	chr5	70819984	70819984	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccatgctggtgactcttcGggcttcccaggaagaagatg	8	9	14	10	1	1	3	0	1	1	2	3	4	2	4	2	4	1	2	2	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:70819984G>T	uc003kbp.1	+	25	5869	c.5606G>T	c.(5605-5607)CGG>CTG	p.R1869L	BDP1_uc003kbo.2_Missense_Mutation_p.R1869L|BDP1_uc003kbq.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1869					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GTGACTCTTCGGGCTTCCCAG	0.468													36	94					2.26627e-22	5.41695e-22	1	0	T	70819984	T	T	70819984	3	4	166	1	0	0	0	0	1	0	0	0	1397	1116	39	3	5704	3	BDP1	5	70819984	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	15874948	70819984	110095276	310	30638											
TMEM171	134285	broad.mit.edu	37	chr5	72427521	72427521	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaaaatgctgcagctacAttcttgcctctatcttctga	12	13	6	10	0	4	2	0	1	4	1	4	2	4	2	1	0	5	3	1	0	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:72427521A>T	uc003kcm.2	+	4	1143	c.939A>T	c.(937-939)ACA>ACT	p.T313T	TMEM171_uc003kcn.3_Silent_p.T312T	NM_173490	NP_775761	Q8WVE6	TM171_HUMAN	transmembrane protein 171 isoform 1	313						integral to membrane					0		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		CTGCAGCTACATTCTTGCCTC	0.378													37	67					0	0	0	0	T	72427521	T	T	72427521	2	4	166	1	0	0	0	0	0	0	0	1	16154	204	8	5		5	TMEM171	5	72427521	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1607537	72427521	108487739	311	30639											
BHMT2	23743	broad.mit.edu	37	chr5	78378765	78378765	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccggagaatgtgctgtgaGgctggtgaaggcaggtaatt	9	9	16	7	1	0	3	0	2	0	1	0	4	0	3	2	5	1	4	2	5	3	2	rs147230129		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:78378765G>A	uc003kft.2	+	5	607	c.584G>A	c.(583-585)AGG>AAG	p.R195K	BHMT2_uc011cth.1_Missense_Mutation_p.R131K	NM_017614	NP_060084	Q9H2M3	BHMT2_HUMAN	betaine-homocysteine methyltransferase 2	195	Hcy-binding.				methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			ovary(1)	1		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	TGTGCTGTGAGGCTGGTGAAG	0.463													50	114					0	0	0	0	A	78378765	A	A	78378765	3	1	166	1	0	0	0	0	1	0	0	0	1429	1000	35	4	602	4	BHMT2	5	78378765	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5951244	78378765	102536495	312	30640											
CMYA5	202333	broad.mit.edu	37	chr5	79034639	79034639	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acacccatcatgttctggagCgtgcagatgaagcaggcagt	11	8	12	10	1	2	2	1	1	1	1	2	3	2	3	1	2	3	4	1	2	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:79034639C>A	uc003kgc.2	+	2	10123	c.10051C>A	c.(10051-10053)CGT>AGT	p.R3351S		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3351						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGTTCTGGAGCGTGCAGATGA	0.488													21	46					4.35082e-09	8.19962e-09	1	0	A	79034639	A	A	79034639	3	1	166	1	0	0	0	0	1	0	0	0	3605	768	27	3	10057	3	CMYA5	5	79034639	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	655874	79034639	101880621	313	30641											
SERINC5	256987	broad.mit.edu	37	chr5	79470855	79470855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agaggaagcctccgacggctCccacatagcgccaggctgca	10	4	12	15	3	0	1	0	0	0	1	2	3	2	2	4	3	3	3	4	3	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:79470855C>T	uc003kgj.2	-	5	602	c.473G>A	c.(472-474)GGA>GAA	p.G158E	SERINC5_uc003kgk.2_Missense_Mutation_p.G158E|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.G158E|SERINC5_uc011ctj.1_Missense_Mutation_p.G158E	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	158	Helical; (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		TCCGACGGCTCCCACATAGCG	0.468													5	8					0	0	0	0	T	79470855	T	T	79470855	3	4	166	1	0	0	0	0	1	0	0	0	14148	855	30	2	982	2	SERINC5	5	79470855	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	436216	79470855	101444405	314	30642											
ANKRD34B	340120	broad.mit.edu	37	chr5	79855120	79855120	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtggagcgtgggggagcttgGgccccttaggggccaatgca	6	7	19	9	1	0	0	0	0	0	0	0	2	0	2	3	6	3	2	3	6	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:79855120G>T	uc010jam.2	-	4	1069	c.719C>A	c.(718-720)CCC>CAC	p.P240H	ANKRD34B_uc003kgw.2_Missense_Mutation_p.P240H|ANKRD34B_uc010jan.2_Missense_Mutation_p.P240H	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	240						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		GGGGAGCTTGGGCCCCTTAGG	0.527													16	48					1.3612e-06	2.40573e-06	1	0	T	79855120	T	T	79855120	3	4	166	1	0	0	0	0	1	0	0	0	663	1232	43	4	829	4	ANKRD34B	5	79855120	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	384265	79855120	101060140	315	30643											
GPR98	84059	broad.mit.edu	37	chr5	89930999	89930999	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccctagatttggggaaatCtgcaatatttctttactggt	10	15	9	7	0	2	1	0	0	2	1	2	2	2	2	1	3	3	1	1	3	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:89930999C>T	uc003kju.2	+	10	2004	c.1908C>T	c.(1906-1908)ATC>ATT	p.I636I	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	636	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGGGGAAATCTGCAATATTT	0.358													22	71					0	0	0	0	T	89930999	T	T	89930999	2	4	166	1	0	0	0	0	0	0	0	1	6760	903	32	2		2	GPR98	5	89930999	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	10075879	89930999	90984261	316	30644											
GPR98	84059	broad.mit.edu	37	chr5	89954097	89954097	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggagcttgtataccagaggTaagtagtgagcttggagaat	13	10	14	4	0	0	3	0	1	0	2	0	5	0	4	1	3	3	5	1	3	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:89954097T>A	uc003kju.2	+	21	4848	c.4752_splice	c.e21+2	p.E1584_splice	GPR98_uc003kjt.2_Splice_Site	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor						cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATACCAGAGGTAAGTAGTGAG	0.373													18	40					0	0	0	0	A	89954097	A	A	89954097	5	1	166	1	0	0	0	0	0	0	1	0	6760	1652	57	5	4836	5	GPR98	5	89954097	Splice_Site	SNP	T	TCGA-CR-7402-01A-11D-2012-08	23098	89954097	90961163	317	30645											
MCTP1	79772	broad.mit.edu	37	chr5	94353071	94353071	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tattgctcttatgctcttacCtcctcgatctcgagcagcta	7	15	6	13	2	3	0	0	0	3	0	6	2	4	0	2	0	5	4	2	0	4	5	rs111625916		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:94353071C>A	uc003kkx.2	-	2	838	c.838G>T	c.(838-840)GGG>TGG	p.G280W	MCTP1_uc003kkv.2_Missense_Mutation_p.G59W|MCTP1_uc003kkw.2_Missense_Mutation_p.G59W|MCTP1_uc003kkz.2_Intron	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	280	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		ATGCTCTTACCTCCTCGATCT	0.403													28	71					1.13719e-10	2.22889e-10	1	0	A	94353071	A	A	94353071	3	1	166	1	0	0	0	0	1	0	0	0	9453	695	24	4	2249	4	MCTP1	5	94353071	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4398974	94353071	86562189	318	30646											
ELL2	22936	broad.mit.edu	37	chr5	95234300	95234300	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagttagaatttacaatcTgaggaggatgtgagatgggc	12	11	15	3	0	1	3	0	2	1	2	1	7	1	6	0	4	1	1	0	4	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:95234300T>A	uc003klr.3	-	8	1519	c.1169A>T	c.(1168-1170)CAG>CTG	p.Q390L		NM_012081	NP_036213	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	390					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		ATTTACAATCTGAGGAGGATG	0.537													38	79					0	0	0	0	A	95234300	A	A	95234300	3	1	166	1	0	0	0	0	1	0	0	0	5087	1580	55	5	773	5	ELL2	5	95234300	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	881229	95234300	85680960	319	30647											
FAM174A	345757	broad.mit.edu	37	chr5	99871504	99871504	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggcagcaaccctgtggccggGcttgagacggacgatcacgg	8	5	16	12	4	1	1	1	1	0	1	1	4	1	2	2	5	2	3	2	5	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:99871504G>T	uc003knj.1	+	1	390	c.270G>T	c.(268-270)GGG>GGT	p.G90G	uc003kni.2_5'Flank	NM_198507	NP_940909	Q8TBP5	F174A_HUMAN	family with sequence similarity 174, member A	90	Extracellular (Potential).					integral to membrane					0						CTGTGGCCGGGCTTGAGACGG	0.726													7	13					8.12818e-05	0.000136164	1	0	T	99871504	T	T	99871504	2	4	166	1	0	0	0	0	0	0	0	1	5523	1190	42	4		4	FAM174A	5	99871504	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4637204	99871504	81043756	320	30648											
SLCO4C1	353189	broad.mit.edu	37	chr5	101606491	101606491	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatgtacaactggtgctattCcttgttgttacacaagtgtc	9	15	9	8	0	0	0	0	0	0	0	2	1	1	0	1	1	4	4	1	1	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:101606491C>T	uc003knm.2	-	3	926	c.639G>A	c.(637-639)AGG>AGA	p.R213R		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	213	Extracellular (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TGGTGCTATTCCTTGTTGTTA	0.333													9	35					0	0	0	0	T	101606491	T	T	101606491	2	4	166	1	0	0	0	0	0	0	0	1	14794	854	30	2		2	SLCO4C1	5	101606491	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1734987	101606491	79308769	321	30649											
SLCO4C1	353189	broad.mit.edu	37	chr5	101627047	101627047	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taaacacaatagaaacttacCttcaaaaagagaccccaatt	20	8	3	10	0	1	2	1	0	0	2	1	3	1	2	3	0	3	0	3	0	9	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:101627047C>T	uc003knm.2	-	2	906	c.619G>A	c.(619-621)GAC>AAC	p.D207N		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	207	Extracellular (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		AGAAACTTACCTTCAAAAAGA	0.348													17	45					0	0	0	0	T	101627047	T	T	101627047	3	4	166	1	0	0	0	0	1	0	0	0	14794	695	24	4	1603	4	SLCO4C1	5	101627047	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	20556	101627047	79288213	322	30650											
PGGT1B	5229	broad.mit.edu	37	chr5	114573587	114573587	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgaagggctctcaagccCgctaagcaagcttctttatt	10	11	9	11	1	2	1	1	1	2	0	3	1	2	1	1	1	4	5	1	1	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:114573587C>G	uc003kqw.3	-	4	468	c.447G>C	c.(445-447)GCG>GCC	p.A149A	PGGT1B_uc003kqx.3_Silent_p.A26A|PGGT1B_uc010jch.2_Silent_p.A149A	NM_005023	NP_005014	P53609	PGTB1_HUMAN	geranylgeranyltransferase type 1 beta	149	PFTB 1.				protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity				0		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)	CTCTCAAGCCCGCTAAGCAAG	0.388													26	75					0	0	0	0	G	114573587	G	G	114573587	2	3	166	1	0	0	0	0	0	0	0	1	11844	639	23	3		3	PGGT1B	5	114573587	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	12946540	114573587	66341673	323	30651											
TMED7-TICAM2	100302736	broad.mit.edu	37	chr5	114916308	114916308	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatatagtttgttgtgtctTatacacagactcctgaaaaa	13	14	6	8	0	1	2	0	1	1	1	2	2	2	2	2	0	1	2	2	0	6	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:114916308T>C	uc003krd.2	-	4	1652	c.646A>G	c.(646-648)AAG>GAG	p.K216E	TMED7-TICAM2_uc003kre.2_Missense_Mutation_p.K385E|TICAM2_uc003krc.2_Missense_Mutation_p.K216E	NM_021649	NP_067681	Q86XR7	TCAM2_HUMAN	toll-like receptor adaptor molecule 2	216	TIR.				I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	Golgi apparatus|intrinsic to membrane|plasma membrane	protein binding|transmembrane receptor activity				0						TGTTGTGTCTTATACACAGAC	0.378													17	44					0	0	0	0	C	114916308	C	C	114916308	3	2	166	1	0	0	0	0	1	0	0	0	16076	1763	61	5		5	TMED7-TICAM2	5	114916308	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	342721	114916308	65998952	324	30652											
AQPEP	206338	broad.mit.edu	37	chr5	115336169	115336169	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctttcttgtttcttgaatGagcatttatttgtcagtgca	7	20	8	6	0	3	2	1	2	2	0	3	2	3	2	0	0	3	4	0	0	2	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:115336169G>T	uc003kro.2	+	8	1719	c.1555G>T	c.(1555-1557)GAG>TAG	p.E519*	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	519	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TTTCTTGAATGAGCATTTATT	0.378													30	87					9.65963e-10	1.86347e-09	1	0	T	115336169	T	T	115336169	4	4	166	1	0	0	0	0	0	1	0	0	834	1291	45	2	1585	2	AQPEP	5	115336169	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	419861	115336169	65579091	325	30653											
FTMT	94033	broad.mit.edu	37	chr5	121187730	121187730	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctctgcgcccggtgcgctgCtgcttcgcgctcccgctgcg	0	10	13	18	7	1	0	0	0	1	0	4	0	2	0	2	1	5	5	2	1	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:121187730C>T	uc003kss.2	+	1	81	c.72C>T	c.(70-72)TGC>TGT	p.C24C		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	24					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		CGGTGCGCTGCTGCTTCGCGC	0.731													4	34					0	0	0	0	T	121187730	T	T	121187730	2	4	166	1	0	0	0	0	0	0	0	1	6119	805	28	4		4	FTMT	5	121187730	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5851561	121187730	59727530	326	30654											
ZNF608	57507	broad.mit.edu	37	chr5	123983092	123983092	+	Frame_Shift_Del	DEL	G	-	-																															ggatcatagctgtggtaataGggagaatgggactctttcag																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:123983092delG	uc003ktq.1	-	4	3108	c.2985delC	c.(2983-2985)CCCfs	p.P995fs	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Frame_Shift_Del_p.P995fs|ZNF608_uc003ktt.1_Frame_Shift_Del_p.P995fs|ZNF608_uc003ktp.1_5'Flank	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	995	Ser-rich.					intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TGTGGTAATAGGGAGAATGGG	0.463													---	---	---								-	123983092	-	-	123983092	7	5	166	1	0	1	0	1	0	0	0	0	18101	987	35	0	1577	0	ZNF608	5	123983092	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	2795362	123983092	56932168	327	30655											
FBN2	2201	broad.mit.edu	37	chr5	127671152	127671152	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcctttctatacctgcaCacgatctcccatctggcatc	7	15	4	15	1	3	0	0	0	3	0	6	1	4	0	3	1	2	2	3	1	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:127671152C>T	uc003kuu.2	-	29	4281	c.3842G>A	c.(3841-3843)TGT>TAT	p.C1281Y	FBN2_uc003kuv.2_Missense_Mutation_p.C1248Y	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1281	EGF-like 19; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TATACCTGCACACGATCTCCC	0.433													26	98					0	0	0	0	T	127671152	T	T	127671152	3	4	166	1	0	0	0	0	1	0	0	0	5735	478	17	4	5044	4	FBN2	5	127671152	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3688060	127671152	53244108	328	30656											
RAD50	10111	broad.mit.edu	37	chr5	131953939	131953939	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgattgttatgaggacaacAgaacttgtgaacaaggatct	15	11	10	5	0	1	4	0	3	1	1	1	6	1	6	0	2	3	1	0	2	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:131953939A>T	uc003kxi.2	+	21	3729	c.3342A>T	c.(3340-3342)ACA>ACT	p.T1114T	RAD50_uc003kxh.2_Silent_p.T975T	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	1114					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAGGACAACAGAACTTGTGA	0.318								Homologous_recombination					26	57					0	0	0	0	T	131953939	T	T	131953939	2	4	166	1	0	0	0	0	0	0	0	1	13049	175	7	5		5	RAD50	5	131953939	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	4282787	131953939	48961321	329	30657											
IL13	3596	broad.mit.edu	37	chr5	131993925	131993925	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggcactgggcctcatggCgcttttgttgaccacggtca	5	12	13	11	2	2	1	2	1	0	0	2	1	2	1	2	4	0	4	2	4	0	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:131993925C>A	uc003kxj.1	+	1	61	c.47C>A	c.(46-48)GCG>GAG	p.A16E		NM_002188	NP_002179	P35225	IL13_HUMAN	interleukin 13 precursor	16					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			ovary(1)|skin(1)	2		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGCCTCATGGCGCTTTTGTTG	0.592											OREG0003464	type=REGULATORY REGION|Gene=IL13|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	18	51					5.03518e-11	9.94855e-11	1	0	A	131993925	A	A	131993925	3	1	166	1	0	0	0	0	1	0	0	0	7667	768	27	3	49	3	IL13	5	131993925	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	39986	131993925	48921335	330	30658											
TGFBI	7045	broad.mit.edu	37	chr5	135394834	135394834	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacattggtgatgaaatcctGgttagcggaggcatcggggc	9	9	15	8	2	0	2	0	2	0	0	2	3	1	3	1	6	1	2	1	6	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:135394834G>T	uc003lbf.3	+	13	1895	c.1734G>T	c.(1732-1734)CTG>CTT	p.L578L	TGFBI_uc003lbg.3_Silent_p.L311L|TGFBI_uc003lbh.3_Silent_p.L404L|TGFBI_uc011cyb.1_Silent_p.L404L|TGFBI_uc010jed.2_Silent_p.L311L|TGFBI_uc010jee.2_5'Flank	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	578	FAS1 4.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATGAAATCCTGGTTAGCGGAG	0.502													10	18					5.16669e-11	1.01981e-10	1	0	T	135394834	T	T	135394834	2	4	166	1	0	0	0	0	0	0	0	1	15886	1335	47	4		4	TGFBI	5	135394834	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3400909	135394834	45520426	331	30659											
WNT8A	7478	broad.mit.edu	37	chr5	137419813	137419813	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tatgctctgggcagctctggGcatatgctgtgctgcattca	6	13	12	10	0	3	0	1	0	2	0	3	0	3	0	0	2	5	7	0	2	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:137419813G>C	uc003lcd.1	+	1	40	c.35G>C	c.(34-36)GGC>GCC	p.G12A	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_5'UTR|WNT8A_uc011cyk.1_5'UTR	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	12					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCAGCTCTGGGCATATGCTGT	0.587													13	38					0	0	0	0	C	137419813	C	C	137419813	3	2	166	1	0	0	0	0	1	0	0	0	17464	1203	42	4	37	4	WNT8A	5	137419813	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2024979	137419813	43495447	332	30660											
PCDHA1	56147	broad.mit.edu	37	chr5	140167848	140167848	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggatcacggtgagccggCgctgacagccacggccactg	9	4	15	13	4	1	2	1	2	0	0	1	4	1	3	3	4	2	1	3	4	1	0	rs149133665		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140167848C>G	uc003lhb.2	+	1	1973	c.1973C>G	c.(1972-1974)GCG>GGG	p.A658G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.A658G	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	658	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGAGCCGGCGCTGACAGCC	0.667													19	81					0	0	0	0	G	140167848	G	G	140167848	3	3	166	1	0	0	0	0	1	0	0	0	11573	768	27	3	1975	3	PCDHA1	5	140167848	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2748035	140167848	40747412	333	30661											
PCDHA1	56147	broad.mit.edu	37	chr5	140167951	140167951	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcgcgggcccagaggcggcGctggtggatgtcaacgtgta	6	7	18	10	5	1	1	1	0	0	1	2	2	1	2	1	5	1	2	1	5	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140167951G>A	uc003lhb.2	+	1	2076	c.2076G>A	c.(2074-2076)GCG>GCA	p.A692A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Silent_p.A692A	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	692	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAGGCGGCGCTGGTGGATG	0.662													24	67					0	0	0	0	A	140167951	A	A	140167951	2	1	166	1	0	0	0	0	0	0	0	1	11573	1074	38	1		1	PCDHA1	5	140167951	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	103	140167951	40747309	334	30662											
PCDHA3	56145	broad.mit.edu	37	chr5	140182402	140182402	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggtgagtgcgcgcgatgcGggcgtgccgcctctgggcag	4	6	19	12	6	1	1	0	1	1	0	1	2	1	1	2	3	3	1	2	3	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140182402G>T	uc003lhf.2	+	1	1620	c.1620G>T	c.(1618-1620)GCG>GCT	p.A540A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.A540A	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	540	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCGATGCGGGCGTGCCGC	0.672													50	131					4.44712e-29	1.09778e-28	1	0	T	140182402	T	T	140182402	2	4	166	1	0	0	0	0	0	0	0	1	11579	1103	39	3		3	PCDHA3	5	140182402	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	14451	140182402	40732858	335	30663											
PCDHA3	56145	broad.mit.edu	37	chr5	140182502	140182502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcctcgggtgggtggcatcGgtggcgcagtgagcgagctg	4	8	20	9	4	0	1	0	1	0	0	2	2	0	1	1	5	3	3	1	5	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140182502G>A	uc003lhf.2	+	1	1720	c.1720G>A	c.(1720-1722)GGT>AGT	p.G574S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.G574S	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	574	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGGCATCGGTGGCGCAGT	0.682													44	86					0	0	0	0	A	140182502	A	A	140182502	3	1	166	1	0	0	0	0	1	0	0	0	11579	1116	39	1	1722	1	PCDHA3	5	140182502	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	100	140182502	40732758	336	30664											
PCDHA5	56143	broad.mit.edu	37	chr5	140203532	140203532	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accgcgctgcggtgctcggcGcagcccaccgaggccgtgtg	4	5	16	16	7	0	0	0	0	0	0	1	1	0	0	4	3	3	3	4	3	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140203532G>T	uc003lhl.2	+	1	2172	c.2172G>T	c.(2170-2172)GCG>GCT	p.A724A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.A724A|PCDHA5_uc003lhj.1_Silent_p.A724A	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	724	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCTCGGCGCAGCCCACCG	0.657													20	63					2.39187e-15	5.17104e-15	1	0	T	140203532	T	T	140203532	2	4	166	1	0	0	0	0	0	0	0	1	11581	1074	38	3		3	PCDHA5	5	140203532	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	21030	140203532	40711728	337	30665											
PCDHA10	56139	broad.mit.edu	37	chr5	140237321	140237321	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagaacgacaacgctcccgCgctgctggcgtctcccgctg	6	6	12	17	7	1	1	0	0	1	1	3	3	2	1	2	1	3	4	2	1	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140237321C>G	uc003lhx.2	+	1	1688	c.1688C>G	c.(1687-1689)GCG>GGG	p.A563G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Missense_Mutation_p.A563G	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	563	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGCTCCCGCGCTGCTGGCG	0.687													25	20					0	0	0	0	G	140237321	G	G	140237321	3	3	166	1	0	0	0	0	1	0	0	0	11574	768	27	3	1690	3	PCDHA10	5	140237321	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	33789	140237321	40677939	338	30666											
PCDHA12	56137	broad.mit.edu	37	chr5	140255363	140255364	+	Nonsense_Mutation	DNP	CA	AG	AG																															tgcgggcggagcgcggagtgCagtatccacctggaggtgat																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140255363_140255364CA>AG	uc003lic.2	+	1	433_434	c.306_307CA>AG	c.(304-309)TGCAGT>TGAGGT	p.102_103CS>*G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Nonsense_Mutation_p.102_103CS>*G	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	102_103	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGAGTGCAGTATCCACCT	0.554													73	186					0	0	0	0	AG	140255364	AG	AG	140255363	4	1	166	1	0	0	0	0	0	1	0	0	11576	718	25	4	308	4	PCDHA12	5	140255363	Nonsense_Mutation	DNP	CA	TCGA-CR-7402-01A-11D-2012-08	18042	140255363	40659897	339	30667											
PCDHAC2	56134	broad.mit.edu	37	chr5	140346602	140346602	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgcatcaaccatctgggtgCgcccagtccgcgctacctgg	6	7	12	16	4	2	0	1	0	1	0	3	0	3	0	4	2	3	2	4	2	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140346602C>A	uc003lii.2	+	1	491	c.251C>A	c.(250-252)GCG>GAG	p.A84E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.A84E	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	84	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCTGGGTGCGCCCAGTCCG	0.697													11	28					4.3838e-07	7.8828e-07	1	0	A	140346602	A	A	140346602	3	1	166	1	0	0	0	0	1	0	0	0	11587	768	27	3	253	3	PCDHAC2	5	140346602	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	91239	140346602	40568658	340	30668											
PCDHB1	29930	broad.mit.edu	37	chr5	140433332	140433332	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccatatgaaatgtgttcAgccactggcactggtaatag	11	12	10	8	0	1	1	1	1	0	0	2	1	2	1	2	2	1	3	2	2	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140433332A>T	uc003lik.1	+	1	2354	c.2277A>T	c.(2275-2277)TCA>TCT	p.S759S		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	759	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATGTGTTCAGCCACTGGCA	0.443													6	92					0	0	0	0	T	140433332	T	T	140433332	2	4	166	1	0	0	0	0	0	0	0	1	11588	175	7	5		5	PCDHB1	5	140433332	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	86730	140433332	40481928	341	30669											
PCDHB2	56133	broad.mit.edu	37	chr5	140474516	140474516	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cggagagtggctcctttgtgGccaatttgttaaaagacctg	9	12	12	8	1	0	2	0	0	0	2	1	3	1	2	3	3	0	2	3	3	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140474516G>T	uc003lil.2	+	1	280	c.142G>T	c.(142-144)GCC>TCC	p.A48S	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	48	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCTTTGTGGCCAATTTGTT	0.498													13	49					1.05317e-09	2.02772e-09	1	0	T	140474516	T	T	140474516	3	4	166	1	0	0	0	0	1	0	0	0	11596	1203	42	4	144	4	PCDHB2	5	140474516	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	41184	140474516	40440744	342	30670											
PCDHB3	56132	broad.mit.edu	37	chr5	140481907	140481907	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggacgccaacgacaactcGcccttcgtgctgtacccgct	7	8	9	17	5	0	0	0	0	0	0	2	2	0	1	3	1	4	3	3	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140481907G>C	uc003lio.2	+	1	1674	c.1674G>C	c.(1672-1674)TCG>TCC	p.S558S	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	558	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGACAACTCGCCCTTCGTGC	0.711													30	76					0	0	0	0	C	140481907	C	C	140481907	2	2	166	1	0	0	0	0	0	0	0	1	11597	1074	38	3		3	PCDHB3	5	140481907	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	7391	140481907	40433353	343	30671											
PCDHB16	57717	broad.mit.edu	37	chr5	140562178	140562178	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcggagacaaaggcaagtccTtgttttctttgttttgctga	8	16	10	7	1	1	2	0	1	1	1	3	3	2	2	1	2	1	4	1	2	2	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140562178T>C	uc003liv.2	+	1	1199	c.44T>C	c.(43-45)CTT>CCT	p.L15P	PCDHB16_uc010jfw.1_Intron	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	15					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGCAAGTCCTTGTTTTCTTT	0.473													39	101					0	0	0	0	C	140562178	C	C	140562178	3	2	166	1	0	0	0	0	1	0	0	0	11595	1609	56	5	46	5	PCDHB16	5	140562178	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	80271	140562178	40353082	344	30672											
PCDHB14	56122	broad.mit.edu	37	chr5	140604444	140604444	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caccttcacccaaacctcctAcaccctgttcgtccgcgaga	9	8	5	19	3	1	1	1	0	0	1	4	2	3	1	6	0	2	1	6	0	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140604444A>G	uc003ljb.2	+	1	1367	c.1367A>G	c.(1366-1368)TAC>TGC	p.Y456C	PCDHB14_uc011dal.1_Missense_Mutation_p.Y303C	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	456	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAAACCTCCTACACCCTGTTC	0.592													58	184					0	0	0	0	G	140604444	G	G	140604444	3	3	166	1	0	0	0	0	1	0	0	0	11593	391	14	5	1369	5	PCDHB14	5	140604444	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	42266	140604444	40310816	345	30673											
PCDHB15	56121	broad.mit.edu	37	chr5	140625859	140625859	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtcttggacgccaatgacaAtgccccggagtttgtgcagg	8	9	14	10	2	1	1	0	1	1	0	1	3	1	3	3	4	2	2	3	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140625859A>T	uc003lje.2	+	1	713	c.713A>T	c.(712-714)AAT>ATT	p.N238I		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	238	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCAATGACAATGCCCCGGAG	0.577													8	23					0	0	0	0	T	140625859	T	T	140625859	3	4	166	1	0	0	0	0	1	0	0	0	11594	101	4	5	715	5	PCDHB15	5	140625859	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	21415	140625859	40289401	346	30674											
ARAP3	64411	broad.mit.edu	37	chr5	141059771	141059771	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacggtcctgggcttcggcaCgggcttagggggctgggctt	3	9	18	11	3	0	0	0	0	0	0	2	0	1	0	1	7	0	5	1	7	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:141059771C>A	uc003llm.2	-	2	361	c.283G>T	c.(283-285)GTG>TTG	p.V95L	ARAP3_uc003lln.2_Missense_Mutation_p.V17L|ARAP3_uc003llo.1_Missense_Mutation_p.V95L	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	95	Pro-rich.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						GGCTTCGGCACGGGCTTAGGG	0.657													22	73					7.41877e-09	1.39013e-08	1	0	A	141059771	A	A	141059771	3	1	166	1	0	0	0	0	1	0	0	0	840	536	19	3	4479	3	ARAP3	5	141059771	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	433912	141059771	39855489	347	30675											
SPRY4	81848	broad.mit.edu	37	chr5	141693814	141693814	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggtcttggcatccccgCtggctgctttgcagatgacg	4	12	13	12	2	1	2	0	1	1	1	2	2	2	2	2	3	3	6	2	3	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:141693814C>A	uc003lml.2	-	2	1119	c.860G>T	c.(859-861)AGC>ATC	p.S287I	SPRY4_uc010jgi.1_Missense_Mutation_p.S310I	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	287					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCATCCCCGCTGGCTGCTTT	0.617									Testicular_Cancer_Familial_Clustering_of				12	33					0.00136819	0.00223845	1	0	A	141693814	A	A	141693814	3	1	166	1	0	0	0	0	1	0	0	0	15174	797	28	4	43	4	SPRY4	5	141693814	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	634043	141693814	39221446	348	30676											
POU4F3	5459	broad.mit.edu	37	chr5	145719828	145719828	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacggaagcgcaaacgcacgTccatcgcggcgccggagaag	12	2	14	13	8	0	1	0	0	0	1	2	3	1	2	2	3	3	2	2	3	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:145719828T>A	uc003loa.2	+	2	927	c.838T>A	c.(838-840)TCC>ACC	p.S280T		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	280	Homeobox.				sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAAACGCACGTCCATCGCGGC	0.612													21	45					0	0	0	0	A	145719828	A	A	145719828	3	1	166	1	0	0	0	0	1	0	0	0	12335	1667	58	5	844	5	POU4F3	5	145719828	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	4026014	145719828	35195432	349	30677											
PPP2R2B	5521	broad.mit.edu	37	chr5	145969694	145969694	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtttgaggatagcccggggcTtgctgttttccctcgaagcc	5	12	13	11	2	0	1	0	1	0	0	2	3	1	2	3	3	3	4	3	3	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:145969694T>A	uc003loe.2	-	9	1673	c.1148A>T	c.(1147-1149)AAG>ATG	p.K383M	PPP2R2B_uc010jgm.2_Missense_Mutation_p.K372M|PPP2R2B_uc003log.3_Missense_Mutation_p.K383M|PPP2R2B_uc003lof.3_Missense_Mutation_p.K383M|PPP2R2B_uc003loi.3_Missense_Mutation_p.K386M|PPP2R2B_uc003loh.3_Missense_Mutation_p.K383M|PPP2R2B_uc003loj.3_Missense_Mutation_p.K363M|PPP2R2B_uc003lok.3_Missense_Mutation_p.K372M|PPP2R2B_uc011dbu.1_Missense_Mutation_p.K389M|PPP2R2B_uc011dbv.1_Missense_Mutation_p.K441M	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	383					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCCGGGGCTTGCTGTTTTC	0.507													38	82					0	0	0	0	A	145969694	A	A	145969694	3	1	166	1	0	0	0	0	1	0	0	0	12445	1609	56	5	187	5	PPP2R2B	5	145969694	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	249866	145969694	34945566	350	30678											
SH3TC2	79628	broad.mit.edu	37	chr5	148407063	148407063	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctagttcctcacaggcagcCagggcctgtctgagcattgg	7	9	13	12	0	2	1	1	1	1	0	3	1	3	1	3	3	2	4	3	3	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:148407063C>A	uc003lpu.2	-	11	2384	c.2232G>T	c.(2230-2232)CTG>CTT	p.L744L	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Silent_p.L388L|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Silent_p.L291L|SH3TC2_uc010jgx.2_Silent_p.L737L|SH3TC2_uc003lpv.1_Silent_p.L291L|SH3TC2_uc011dbz.1_Silent_p.L629L	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	744							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAGGCAGCCAGGGCCTGTC	0.592													21	40					3.51602e-12	7.04641e-12	1	0	A	148407063	A	A	148407063	2	1	166	1	0	0	0	0	0	0	0	1	14327	581	21	4		4	SH3TC2	5	148407063	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2437369	148407063	32508197	351	30679											
CAMK2A	815	broad.mit.edu	37	chr5	149636159	149636159	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caggtcccggtgcaccacccCcatctggtggcagtgcagca	7	6	12	16	1	1	0	0	0	1	0	2	0	2	0	4	4	3	4	4	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:149636159C>A	uc003lru.2	-	6	603	c.388G>T	c.(388-390)GGG>TGG	p.G130W	CAMK2A_uc003lrt.2_Missense_Mutation_p.G130W|CAMK2A_uc010jhe.2_Missense_Mutation_p.G110W|CAMK2A_uc010jhf.1_Missense_Mutation_p.G2W	NM_171825	NP_741960	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II	130	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCACCACCCCCATCTGGTGG	0.637													6	30					3.59834e-05	6.10098e-05	1	0	A	149636159	A	A	149636159	3	1	166	1	0	0	0	0	1	0	0	0	2611	623	22	4	1137	4	CAMK2A	5	149636159	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1229096	149636159	31279101	352	30680											
ARSI	340075	broad.mit.edu	37	chr5	149678016	149678016	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagccccgacgggtgggcagAcactccttccggtagaagcc	9	5	13	14	3	0	2	0	0	0	2	2	3	2	2	5	3	2	2	5	3	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:149678016A>G	uc003lrv.2	-	2	1060	c.471T>C	c.(469-471)TGT>TGC	p.C157C		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	157						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGTGGGCAGACACTCCTTCC	0.607													19	38					0	0	0	0	G	149678016	G	G	149678016	2	3	166	1	0	0	0	0	0	0	0	1	996	273	10	5		5	ARSI	5	149678016	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	41857	149678016	31237244	353	30681											
KIF4B	285643	broad.mit.edu	37	chr5	154394597	154394597	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccctgatggagaagaatcAgtccctggtagaggagaatg	13	8	13	7	0	1	5	1	1	0	4	3	7	3	5	2	3	0	1	2	3	4	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:154394597A>T	uc010jih.1	+	1	1338	c.1178A>T	c.(1177-1179)CAG>CTG	p.Q393L		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	393	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GAGAAGAATCAGTCCCTGGTA	0.468													33	100					0	0	0	0	T	154394597	T	T	154394597	3	4	166	1	0	0	0	0	1	0	0	0	8343	188	7	5	1180	5	KIF4B	5	154394597	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	4716581	154394597	26520663	354	30682											
HAVCR1	26762	broad.mit.edu	37	chr5	156479381	156479381	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctgttttacctggttcatGgttctgcctgggcaaaggca	7	14	11	9	0	3	0	1	0	2	0	3	0	3	0	2	4	2	5	2	4	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:156479381G>T	uc010jij.1	-	4	849	c.664C>A	c.(664-666)CAT>AAT	p.H222N	HAVCR1_uc011ddl.1_Missense_Mutation_p.H53N|HAVCR1_uc003lwi.2_Missense_Mutation_p.H222N|HAVCR1_uc011ddm.1_Missense_Mutation_p.H222N	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	217	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTGGTTCATGGTTCTGCCTG	0.488													50	138					4.18559e-23	1.01031e-22	1	0	T	156479381	T	T	156479381	3	4	166	1	0	0	0	0	1	0	0	0	7012	1348	47	4	454	4	HAVCR1	5	156479381	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2084784	156479381	24435879	355	30683											
NIPAL4	348938	broad.mit.edu	37	chr5	156899365	156899365	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcgtgtttgctgtgcttctGctggtgtcatgcctcatcct	3	17	10	11	1	3	0	2	0	1	0	5	0	4	0	2	1	4	4	2	1	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:156899365G>A	uc003lwx.3	+	6	914	c.798G>A	c.(796-798)CTG>CTA	p.L266L	ADAM19_uc003lww.1_Intron|NIPAL4_uc011ddq.1_Silent_p.L247L	NM_001099287	NP_001092757	Q0D2K0	NIPA4_HUMAN	ichthyin protein	266	Helical; (Potential).					integral to membrane	receptor activity				0						CTGTGCTTCTGCTGGTGTCAT	0.507											OREG0016979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	150					0	0	0	0	A	156899365	A	A	156899365	2	1	166	1	0	0	0	0	0	0	0	1	10481	1306	46	4		4	NIPAL4	5	156899365	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	419984	156899365	24015895	356	30684											
ADAM19	8728	broad.mit.edu	37	chr5	156929850	156929850	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcttccccatcttccagAtacccgttcccacacctccg	7	10	3	21	2	2	1	0	0	2	1	6	1	6	1	7	0	1	1	7	0	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:156929850A>T	uc003lwz.2	-	12	1333	c.1269T>A	c.(1267-1269)TAT>TAA	p.Y423*	ADAM19_uc003lww.1_Nonsense_Mutation_p.Y156*|ADAM19_uc003lwy.2_Nonsense_Mutation_p.Y22*|ADAM19_uc011ddr.1_Nonsense_Mutation_p.Y354*	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	423	Disintegrin.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATCTTCCAGATACCCGTTCC	0.527													44	107					0	0	0	0	T	156929850	T	T	156929850	4	4	166	1	0	0	0	0	0	1	0	0	240	340	12	5	1535	5	ADAM19	5	156929850	Nonsense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	30485	156929850	23985410	357	30685											
LSM11	134353	broad.mit.edu	37	chr5	157181901	157181901	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcaagattcctccaagaagGaagcagattctaagtctgca	14	10	8	9	0	3	3	1	0	2	3	5	4	5	4	2	1	2	2	2	1	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:157181901G>T	uc003lxe.1	+	4	716	c.712G>T	c.(712-714)GAA>TAA	p.E238*	LSM11_uc003lxf.1_5'Flank	NM_173491	NP_775762	P83369	LSM11_HUMAN	LSM11, U7 small nuclear RNA associated	238					histone mRNA 3'-end processing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	histone pre-mRNA 3'end processing complex|nucleoplasm|U7 snRNP	protein binding|U7 snRNA binding				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTCCAAGAAGGAAGCAGATTC	0.423													22	39					3.10358e-05	5.2804e-05	1	0	T	157181901	T	T	157181901	4	4	166	1	0	0	0	0	0	1	0	0	9102	1175	41	2	726	2	LSM11	5	157181901	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	252051	157181901	23733359	358	30686											
IL12B	3593	broad.mit.edu	37	chr5	158753716	158753716	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggttaccatctttcttcagTtcccatatggccacgagggg	7	13	10	11	1	3	0	1	0	2	0	4	1	4	0	3	4	1	2	3	4	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:158753716T>G	uc003lxr.1	-	2	117	c.75A>C	c.(73-75)GAA>GAC	p.E25D		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	25	Ig-like C2-type.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTTCTTCAGTTCCCATATGG	0.438													33	77					0	0	0	0	G	158753716	G	G	158753716	3	3	166	1	0	0	0	0	1	0	0	0	7664	1722	60	5	935	5	IL12B	5	158753716	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1571815	158753716	22161544	359	30687											
ATP10B	23120	broad.mit.edu	37	chr5	160071164	160071164	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcatagatgacaatgccAacagccatctcggtgtttct	10	11	8	12	1	2	2	0	1	2	1	3	2	2	2	3	1	4	2	3	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:160071164A>G	uc003lym.1	-	9	1696	c.849T>C	c.(847-849)GTT>GTC	p.V283V	ATP10B_uc003lyp.2_Silent_p.V283V|ATP10B_uc011deg.1_Silent_p.V327V|ATP10B_uc003lyo.2_Silent_p.V255V	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	283	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGACAATGCCAACAGCCATCT	0.493													15	63					0	0	0	0	G	160071164	G	G	160071164	2	3	166	1	0	0	0	0	0	0	0	1	1119	117	5	5		5	ATP10B	5	160071164	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1317448	160071164	20844096	360	30688											
DOCK2	1794	broad.mit.edu	37	chr5	169188524	169188524	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatttttcctgccctcagcCaactcctgtatgagttctac	7	15	5	14	0	2	1	1	1	1	0	4	1	4	1	4	0	4	2	4	0	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:169188524C>A	uc003maf.2	+	25	2529	c.2449C>A	c.(2449-2451)CAA>AAA	p.Q817K	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.Q309K	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	817					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGCCCTCAGCCAACTCCTGTA	0.483													38	117					5.59293e-11	1.10172e-10	1	0	A	169188524	A	A	169188524	3	1	166	1	0	0	0	0	1	0	0	0	4709	608	21	4	2547	4	DOCK2	5	169188524	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	9117360	169188524	11726736	361	30689											
DOCK2	1794	broad.mit.edu	37	chr5	169454881	169454881	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcagtttgaaaacgaaatCatcctgaagctggaccacga	14	9	8	10	2	2	2	2	2	0	0	3	5	3	3	2	1	2	2	2	1	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:169454881C>T	uc003maf.2	+	34	3476	c.3396C>T	c.(3394-3396)ATC>ATT	p.I1132I	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.I624I	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1132	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAAACGAAATCATCCTGAAGC	0.418													26	63					0	0	0	0	T	169454881	T	T	169454881	2	4	166	1	0	0	0	0	0	0	0	1	4709	816	29	2		2	DOCK2	5	169454881	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	266357	169454881	11460379	362	30690											
KCNIP1	30820	broad.mit.edu	37	chr5	170147332	170147332	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccttcccacaggagtgccCcagtggtgtggtcaacgaag	8	7	12	14	1	1	0	1	0	0	0	2	2	2	1	5	3	2	0	5	3	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:170147332C>A	uc003mas.2	+	4	756	c.227C>A	c.(226-228)CCC>CAC	p.P76H	KCNIP1_uc003map.2_Missense_Mutation_p.P74H|KCNIP1_uc003mat.2_Missense_Mutation_p.P65H|KCNIP1_uc010jjp.2_Missense_Mutation_p.P37H|KCNIP1_uc010jjq.2_Missense_Mutation_p.P65H	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	76	EF-hand 1; degenerate.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGGAGTGCCCCAGTGGTGTG	0.547													9	30					2.17888e-05	3.72003e-05	1	0	A	170147332	A	A	170147332	3	1	166	1	0	0	0	0	1	0	0	0	8078	623	22	4	333	4	KCNIP1	5	170147332	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	692451	170147332	10767928	363	30691											
STK10	6793	broad.mit.edu	37	chr5	171523476	171523476	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccccctcatcccggccgTcttcgatctcttccatcacc	4	12	4	21	3	4	0	2	0	2	0	9	1	7	0	6	1	0	0	6	1	0	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:171523476T>A	uc003mbo.1	-	8	1259	c.959A>T	c.(958-960)GAC>GTC	p.D320V		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	320							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATCCCGGCCGTCTTCGATCTC	0.642													32	81					0	0	0	0	A	171523476	A	A	171523476	3	1	166	1	0	0	0	0	1	0	0	0	15352	1667	58	5	1995	5	STK10	5	171523476	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1376144	171523476	9391784	364	30692											
EIF4E1B	253314	broad.mit.edu	37	chr5	176072481	176072481	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagatcgctgtgtggacgaGggaggcggaaaaccaggcgg	11	4	18	8	4	0	1	0	0	0	1	1	5	0	4	1	6	1	1	1	6	3	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176072481G>A	uc010jkf.1	+	8	1162	c.578G>A	c.(577-579)AGG>AAG	p.R193K	TSPAN17_uc003mes.3_5'Flank|TSPAN17_uc003met.2_5'Flank|TSPAN17_uc003meu.2_5'Flank|TSPAN17_uc003mev.2_5'Flank|TSPAN17_uc003mew.2_5'Flank	NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	193					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGTGGACGAGGGAGGCGGAA	0.622													13	29					0	0	0	0	A	176072481	A	A	176072481	3	1	166	1	0	0	0	0	1	0	0	0	5053	1000	35	4	600	4	EIF4E1B	5	176072481	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4549005	176072481	4842779	365	30693											
NSD1	64324	broad.mit.edu	37	chr5	176637567	176637567	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctaagagtgcagagcctggaAccgagacgtctcaggttaat	12	8	12	9	2	1	3	1	0	1	3	2	5	1	4	2	2	3	2	2	2	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176637567A>T	uc003mfr.3	+	5	2305	c.2167A>T	c.(2167-2169)ACC>TCC	p.T723S	NSD1_uc003mft.3_Missense_Mutation_p.T454S|NSD1_uc003mfs.1_Missense_Mutation_p.T620S|NSD1_uc011dfx.1_Missense_Mutation_p.T371S	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	723					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGAGCCTGGAACCGAGACGTC	0.428			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			26	58					0	0	0	0	T	176637567	T	T	176637567	3	4	166	1	0	0	0	0	1	0	0	0	10723	43	2	5	2181	5	NSD1	5	176637567	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	565086	176637567	4277693	366	30694											
NSD1	64324	broad.mit.edu	37	chr5	176675254	176675254	+	Frame_Shift_Del	DEL	G	-	-																															aaggtgtagaacacgatcccGggatgcctgcctctaaaaaa																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176675254delG	uc003mfr.3	+	11	4708	c.4570delG	c.(4570-4572)GGGfs	p.G1524fs	NSD1_uc003mft.3_Frame_Shift_Del_p.G1255fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.G1421fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.G1172fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1524					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ACACGATCCCGGGATGCCTGC	0.493			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---								-	176675254	-	-	176675254	7	5	166	1	0	1	0	1	0	0	0	0	10723	1116	39	0	4608	0	NSD1	5	176675254	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	37687	176675254	4240006	367	30695											
NSD1	64324	broad.mit.edu	37	chr5	176709538	176709538	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagctcgaattcgctatgctCaagaacatgatatcactaat	14	11	7	9	2	2	2	2	1	0	1	4	4	2	2	0	0	3	3	0	0	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176709538C>T	uc003mfr.3	+	19	6103	c.5965C>T	c.(5965-5967)CAA>TAA	p.Q1989*	NSD1_uc003mft.3_Nonsense_Mutation_p.Q1720*|NSD1_uc011dfx.1_Nonsense_Mutation_p.Q1637*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1989	SET.			RYAQEH -> KHAHEN (in Ref. 3; AAK92049).	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCGCTATGCTCAAGAACATGA	0.368			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			24	95					0	0	0	0	T	176709538	T	T	176709538	4	4	166	1	0	0	0	0	0	1	0	0	10723	827	29	2	6035	2	NSD1	5	176709538	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	34284	176709538	4205722	368	30696											
ZNF354C	30832	broad.mit.edu	37	chr5	178503532	178503532	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcccagagggccttgtaccgGgaggtgatgctggagaacta	9	7	16	9	1	0	3	0	1	0	2	0	5	0	4	3	4	3	2	3	4	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:178503532G>T	uc003mju.2	+	3	229	c.114G>T	c.(112-114)CGG>CGT	p.R38R		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	38	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		CCTTGTACCGGGAGGTGATGC	0.527													24	82					6.36457e-07	1.14027e-06	1	0	T	178503532	T	T	178503532	2	4	166	1	0	0	0	0	0	0	0	1	17933	1219	43	4		4	ZNF354C	5	178503532	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1793994	178503532	2411728	369	30697											
BTNL3	10917	broad.mit.edu	37	chr5	180424227	180424227	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcccagcactgggctcacttCctctcatttccatcgtggga	6	12	8	15	1	2	0	2	0	1	0	7	1	5	1	3	2	1	2	3	2	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:180424227C>G	uc003mmr.2	+	3	540	c.412C>G	c.(412-414)CCT>GCT	p.P138A		NM_197975	NP_932079	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3 precursor	138	Ig-like V-type.|Extracellular (Potential).				lipid metabolic process	integral to membrane					0	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GGGCTCACTTCCTCTCATTTC	0.498													39	128					0	0	0	0	G	180424227	G	G	180424227	3	3	166	1	0	0	0	0	1	0	0	0	1571	855	30	2	422	2	BTNL3	5	180424227	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1920695	180424227	491033	370	30698											
JARID2	3720	broad.mit.edu	37	chr6	15452388	15452388	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctaagacagaagattttcttAcctttctctgccttcgaggt	9	15	7	10	1	2	3	0	0	2	3	4	4	2	3	2	1	2	0	2	1	3	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:15452388A>C	uc003nbj.2	+	4	719	c.475A>C	c.(475-477)ACC>CCC	p.T159P	JARID2_uc011diu.1_Intron|JARID2_uc011div.1_5'UTR|JARID2_uc011diw.1_Missense_Mutation_p.T121P	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	159					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGATTTTCTTACCTTTCTCTG	0.468													26	85					0	0	0	0	C	15452388	C	C	15452388	3	2	166	1	0	0	0	0	1	0	0	0	7984	391	14	5	489	5	JARID2	6	15452388	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08		15452388	155662679	371	30699											
ALDH5A1	7915	broad.mit.edu	37	chr6	24533787	24533787	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggagagtggcagagcagctGgaagtgggcatggttggcgt	8	8	20	5	1	0	2	0	0	0	2	0	4	0	3	0	6	2	5	0	6	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:24533787G>A	uc003neg.2	+	10	1483	c.1455G>A	c.(1453-1455)CTG>CTA	p.L485L	ALDH5A1_uc003nef.2_Silent_p.L498L	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	485					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	CAGAGCAGCTGGAAGTGGGCA	0.493													78	71					0	0	0	0	A	24533787	A	A	24533787	2	1	166	1	0	0	0	0	0	0	0	1	502	1335	47	4		4	ALDH5A1	6	24533787	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	9081399	24533787	146581280	372	30700											
NKAPL	222698	broad.mit.edu	37	chr6	28228212	28228212	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatggaggctgtacgactgCgtaaggagaaccagatctac	13	7	13	8	2	1	2	0	0	1	2	1	6	1	3	1	3	4	3	1	3	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:28228212C>T	uc003nkt.2	+	1	1115	c.1063C>T	c.(1063-1065)CGT>TGT	p.R355C	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	355										upper_aerodigestive_tract(1)|ovary(1)	2						TGTACGACTGCGTAAGGAGAA	0.443													27	174					0	0	0	0	T	28228212	T	T	28228212	3	4	166	1	0	0	0	0	1	0	0	0	10494	768	27	1	1065	1	NKAPL	6	28228212	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3694425	28228212	142886855	373	30701											
OR2J3	442186	broad.mit.edu	37	chr6	29080330	29080330	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctcattctcacttcttaTggtgccatcgtccgagctat	7	15	6	13	2	3	0	2	0	2	0	7	1	5	0	3	1	2	1	3	1	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:29080330T>A	uc011dll.1	+	1	663	c.663T>A	c.(661-663)TAT>TAA	p.Y221*		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	221	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCACTTCTTATGGTGCCATCG	0.448													16	137					0	0	0	0	A	29080330	A	A	29080330	4	1	166	1	0	0	0	0	0	1	0	0	11058	1471	51	5	665	5	OR2J3	6	29080330	Nonsense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	852118	29080330	142034737	374	30702											
DDR1	780	broad.mit.edu	37	chr6	30860151	30860151	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttccggcgtggccctgccAtggcctgggagggggagccc	3	6	18	14	2	0	0	0	0	0	0	1	2	1	2	5	6	2	1	5	6	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:30860151A>G	uc003nrr.2	+	9	1190	c.931A>G	c.(931-933)ATG>GTG	p.M311V	DDR1_uc010jse.2_Missense_Mutation_p.M311V|DDR1_uc003nrq.2_Missense_Mutation_p.M311V|DDR1_uc003nrs.2_Missense_Mutation_p.M311V|DDR1_uc003nrt.2_Missense_Mutation_p.M311V|DDR1_uc011dms.1_Missense_Mutation_p.M329V|DDR1_uc003nru.2_Missense_Mutation_p.M311V|DDR1_uc003nrv.2_Missense_Mutation_p.M311V|DDR1_uc003nrw.1_Missense_Mutation_p.M110V|DDR1_uc003nry.1_5'Flank|DDR1_uc003nrx.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	311	Extracellular (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	TGGCCCTGCCATGGCCTGGGA	0.697													31	36					0	0	0	0	G	30860151	G	G	30860151	3	3	166	1	0	0	0	0	1	0	0	0	4353	217	8	5	957	5	DDR1	6	30860151	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1779821	30860151	140254916	375	30703											
PPT2	9374	broad.mit.edu	37	chr6	32122555	32122555	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgctggaatacatcaatgagGtctggcaggggacacctggg	10	8	15	8	0	2	1	1	1	1	0	2	3	2	3	1	6	2	2	1	6	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:32122555G>T	uc003nzx.2	+	2	751	c.183_splice	c.e2+1	p.E61_splice	PRRT1_uc003nzs.2_5'Flank|PRRT1_uc003nzt.2_5'Flank|PRRT1_uc003nzu.2_5'Flank|uc003nzv.3_5'Flank|PPT2_uc003nzw.2_Splice_Site_p.E67_splice|PPT2_uc011dpi.1_Splice_Site|PPT2_uc003nzy.1_Splice_Site|PPT2_uc003nzz.2_Splice_Site_p.E61_splice|PPT2_uc003oaa.2_Splice_Site_p.E61_splice|PPT2_uc010jtu.1_Splice_Site_p.E61_splice	NM_005155	NP_005146	Q9UMR5	PPT2_HUMAN	palmitoyl-protein thioesterase 2 isoform a						protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0						CATCAATGAGGTCTGGCAGGG	0.647													32	39					1.88708e-17	4.24648e-17	1	0	T	32122555	T	T	32122555	5	4	166	1	0	0	0	0	0	0	1	0	12472	1275	44	4	208	4	PPT2	6	32122555	Splice_Site	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1262404	32122555	138992512	376	30704											
NOTCH4	4855	broad.mit.edu	37	chr6	32169141	32169141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctcagtaccaccagcagggCcagggagggcccccactctg	8	4	13	16	0	2	0	1	0	1	0	2	1	2	1	5	3	2	3	5	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:32169141C>T	uc003obb.2	-	22	4031	c.3892G>A	c.(3892-3894)GCC>ACC	p.A1298T	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1298	Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						ACCAGCAGGGCCAGGGAGGGC	0.637													45	25					0	0	0	0	T	32169141	T	T	32169141	3	4	166	1	0	0	0	0	1	0	0	0	10605	739	26	4	2155	4	NOTCH4	6	32169141	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	46586	32169141	138945926	377	30705											
COL11A2	1302	broad.mit.edu	37	chr6	33146101	33146101	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcaccgactctccaggcagcCctcgaggcccaatctccccg	7	6	8	20	3	3	0	1	0	2	0	6	2	3	0	6	2	1	1	6	2	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:33146101C>A	uc003ocx.1	-	20	2030	c.1802G>T	c.(1801-1803)GGG>GTG	p.G601V	COL11A2_uc010jul.1_5'Flank|COL11A2_uc003ocy.1_Missense_Mutation_p.G515V|COL11A2_uc003ocz.1_Missense_Mutation_p.G494V	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	601	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TCCAGGCAGCCCTCGAGGCCC	0.617													18	141					4.75885e-15	1.02498e-14	1	0	A	33146101	A	A	33146101	3	1	166	1	0	0	0	0	1	0	0	0	3683	623	22	4	3596	4	COL11A2	6	33146101	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	976960	33146101	137968966	378	30706											
RGL2	5863	broad.mit.edu	37	chr6	33262943	33262943	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgggaataattatcctcCtcggagaaaatctggcagag	12	10	10	9	1	2	2	0	0	2	2	5	4	4	3	2	3	0	1	2	3	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:33262943C>T	uc003odv.2	-	9	1303	c.1170G>A	c.(1168-1170)GAG>GAA	p.E390E	RGL2_uc003odu.2_5'UTR|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_Silent_p.E308E|RGL2_uc011drb.1_Silent_p.E308E	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	390	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						AATTATCCTCCTCGGAGAAAA	0.577													4	23					0	0	0	0	T	33262943	T	T	33262943	2	4	166	1	0	0	0	0	0	0	0	1	13342	680	24	4		4	RGL2	6	33262943	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	116842	33262943	137852124	379	30707											
CPNE5	57699	broad.mit.edu	37	chr6	36766231	36766231	+	Splice_Site	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagttactggcagaactcaCgtgtttggataaatcaggac	12	10	11	8	1	2	1	2	0	0	1	2	3	2	3	0	3	2	4	0	3	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:36766231C>A	uc003omr.1	-	5	394	c.327_splice	c.e5+1	p.H109_splice	CPNE5_uc003oms.1_Splice_Site_p.H71_splice	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V											skin(1)	1						GCAGAACTCACGTGTTTGGAT	0.512													28	28					8.58068e-18	1.93981e-17	1	0	A	36766231	A	A	36766231	5	1	166	1	0	0	0	0	0	0	1	0	3830	550	19	3	1521	3	CPNE5	6	36766231	Splice_Site	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3503288	36766231	134348836	380	30708											
DNAH8	1769	broad.mit.edu	37	chr6	38885916	38885916	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagaagtgttgcctctgaaGgtaaaagtttccttccttct	10	14	9	8	0	2	2	0	1	2	1	4	3	4	2	3	1	1	3	3	1	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:38885916G>A	uc003ooe.1	+	68	10473	c.9873G>A	c.(9871-9873)AAG>AAA	p.K3291K	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGCCTCTGAAGGTAAAAGTTT	0.373													13	48					0	0	0	0	A	38885916	A	A	38885916	2	1	166	1	0	0	0	0	0	0	0	1	4629	1014	35	4		4	DNAH8	6	38885916	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2119685	38885916	132229151	381	30709											
NCR2	9436	broad.mit.edu	37	chr6	41304148	41304148	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctctaagtccgtcagattcTatctggtggtatctccaggt	7	15	9	10	1	5	1	1	0	4	1	8	1	6	1	2	3	0	1	2	3	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:41304148T>G	uc003oqh.2	+	2	463	c.376T>G	c.(376-378)TAT>GAT	p.Y126D	NCR2_uc003oqi.2_Missense_Mutation_p.Y126D|NCR2_uc003oqj.2_Missense_Mutation_p.Y126D	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	126	Extracellular (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CGTCAGATTCTATCTGGTGGT	0.532													59	31					0	0	0	0	G	41304148	G	G	41304148	3	3	166	1	0	0	0	0	1	0	0	0	10292	1522	53	5	382	5	NCR2	6	41304148	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2418232	41304148	129810919	382	30710											
TRERF1	55809	broad.mit.edu	37	chr6	42236484	42236484	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtatttcttgcatggagataCgctgttgcccggcttgctgc	5	14	12	10	2	1	1	0	0	1	1	1	2	1	1	1	2	5	6	1	2	2	6	rs147382652		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:42236484C>A	uc003osd.2	-	5	1408	c.845G>T	c.(844-846)CGT>CTT	p.R282L	TRERF1_uc011duq.1_Missense_Mutation_p.R282L|TRERF1_uc003osb.2_Missense_Mutation_p.R121L|TRERF1_uc003osc.2_Missense_Mutation_p.R121L|TRERF1_uc003ose.2_Missense_Mutation_p.R282L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	282	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CATGGAGATACGCTGTTGCCC	0.488													91	69					3.77759e-48	9.56599e-48	1	0	A	42236484	A	A	42236484	3	1	166	1	0	0	0	0	1	0	0	0	16542	536	19	3	2813	3	TRERF1	6	42236484	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	932336	42236484	128878583	383	30711											
PTCRA	171558	broad.mit.edu	37	chr6	42890971	42890971	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cggatggcacctggaccaacTtggcccatctctccctgcct	6	9	9	17	1	1	0	0	0	1	0	3	2	2	2	5	4	2	1	5	4	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:42890971T>G	uc003osx.2	+	2	346	c.265T>G	c.(265-267)TTG>GTG	p.L89V	PTCRA_uc011duz.1_Silent_p.T99T|PTCRA_uc010jxx.1_Silent_p.T49T|PTCRA_uc010jxy.2_Missense_Mutation_p.L64V|PTCRA_uc010jxz.2_Intron	NM_138296	NP_612153	Q6ISU1	PTCRA_HUMAN	pre T-cell antigen receptor alpha precursor	89	Extracellular (Potential).					integral to membrane	receptor activity			ovary(2)	2	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CTGGACCAACTTGGCCCATCT	0.622													29	156					0	0	0	0	G	42890971	G	G	42890971	3	3	166	1	0	0	0	0	1	0	0	0	12797	1606	56	5	271	5	PTCRA	6	42890971	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	654487	42890971	128224096	384	30712											
CENPQ	55166	broad.mit.edu	37	chr6	49456174	49456174	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggaagaagaagaggagaGagtaaaacaggtaattattt	18	8	14	1	0	0	4	0	0	0	4	0	7	0	6	0	4	1	2	0	4	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:49456174G>T	uc003ozh.1	+	7	676	c.587G>T	c.(586-588)AGA>ATA	p.R196I		NM_018132	NP_060602	Q7L2Z9	CENPQ_HUMAN	centromere protein Q	196	Potential.				CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				ovary(2)	2	Lung NSC(77;0.0128)					GAAGAGGAGAGAGTAAAACAG	0.313													36	35					3.93418e-24	9.54331e-24	1	0	T	49456174	T	T	49456174	3	4	166	1	0	0	0	0	1	0	0	0	3256	942	33	2	609	2	CENPQ	6	49456174	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	6565203	49456174	121658893	385	30713											
RHAG	6005	broad.mit.edu	37	chr6	49578777	49578777	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tactgccacaatgcctgcaaGgcctcccactacaccaggta	11	7	7	16	0	0	0	0	0	0	0	1	0	1	0	5	2	5	2	5	2	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:49578777G>T	uc003ozk.3	-	7	1089	c.1027C>A	c.(1027-1029)CTT>ATT	p.L343I	RHAG_uc010jzl.2_Missense_Mutation_p.L343I|RHAG_uc010jzm.2_Intron	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	343	Helical; (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					ATGCCTGCAAGGCCTCCCACT	0.473													50	48					2.9001e-28	7.132e-28	1	0	T	49578777	T	T	49578777	3	4	166	1	0	0	0	0	1	0	0	0	13380	1000	35	4	218	4	RHAG	6	49578777	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	122603	49578777	121536290	386	30714											
CRISP2	7180	broad.mit.edu	37	chr6	49665662	49665662	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctacctggtaagtcgagtaCcaaacaagctgcaaattaac	15	8	7	11	1	0	0	0	0	0	0	1	1	0	0	3	1	6	4	3	1	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:49665662C>A	uc003ozq.2	-	8	682	c.426G>T	c.(424-426)TGG>TGT	p.W142C	CRISP2_uc003ozl.2_Missense_Mutation_p.W142C|CRISP2_uc003ozn.2_Missense_Mutation_p.W142C|CRISP2_uc003ozr.2_Missense_Mutation_p.W142C|CRISP2_uc003ozo.2_Missense_Mutation_p.W142C|CRISP2_uc003ozm.2_Missense_Mutation_p.W142C|CRISP2_uc003ozp.2_Missense_Mutation_p.W142C	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	142						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AAGTCGAGTACCAAACAAGCT	0.313													20	128					8.34094e-07	1.48351e-06	1	0	A	49665662	A	A	49665662	3	1	166	1	0	0	0	0	1	0	0	0	3895	508	18	4	317	4	CRISP2	6	49665662	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	86885	49665662	121449405	387	30715											
PKHD1	5314	broad.mit.edu	37	chr6	51750673	51750673	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaagcttacctgggcacCacctgcactttcccaaactg	13	8	6	14	0	0	0	0	0	0	0	1	0	1	0	4	1	4	3	4	1	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:51750673C>A	uc003pah.1	-	45	7483	c.7207G>T	c.(7207-7209)GGT>TGT	p.G2403C	PKHD1_uc010jzn.1_Missense_Mutation_p.G386C|PKHD1_uc003pai.2_Missense_Mutation_p.G2403C	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2403	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					ACCTGGGCACCACCTGCACTT	0.353													14	46					1.3612e-06	2.40573e-06	1	0	A	51750673	A	A	51750673	3	1	166	1	0	0	0	0	1	0	0	0	12026	594	21	4	5148	4	PKHD1	6	51750673	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2085011	51750673	119364394	388	30716											
PKHD1	5314	broad.mit.edu	37	chr6	51947209	51947209	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggtccggcatgtcaccaCaggcaaatccaagaaaacag	14	5	9	13	1	1	1	1	0	0	1	3	1	3	1	4	3	1	2	4	3	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:51947209C>T	uc003pah.1	-	4	538	c.262G>A	c.(262-264)GTG>ATG	p.V88M	PKHD1_uc003pai.2_Missense_Mutation_p.V88M	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	88	Extracellular (Potential).|IPT/TIG 1; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CATGTCACCACAGGCAAATCC	0.488													173	135					0	0	0	0	T	51947209	T	T	51947209	3	4	166	1	0	0	0	0	1	0	0	0	12026	478	17	4	12257	4	PKHD1	6	51947209	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	196536	51947209	119167858	389	30717											
TINAG	27283	broad.mit.edu	37	chr6	54173485	54173485	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccgttttgcaaggtactcGattcaaaagagccattttcc	11	12	7	11	2	1	1	1	0	0	1	3	2	2	1	3	1	3	3	3	1	4	6	rs147898099		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:54173485G>T	uc003pcj.2	+	1	283	c.137G>T	c.(136-138)CGA>CTA	p.R46L	TINAG_uc003pci.2_Missense_Mutation_p.R46L|TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	46					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			CAAGGTACTCGATTCAAAAGA	0.428													33	165					1.45844e-13	3.02171e-13	1	0	T	54173485	T	T	54173485	3	4	166	1	0	0	0	0	1	0	0	0	15987	1058	37	3	139	3	TINAG	6	54173485	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2226276	54173485	116941582	390	30718											
TINAG	27283	broad.mit.edu	37	chr6	54214631	54214631	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgccacgaagccatgtccCaacaacgtagaaaaatctaa	17	6	6	12	2	1	1	0	0	1	1	2	2	2	1	3	0	4	1	3	0	7	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:54214631C>T	uc003pcj.2	+	7	1163	c.1017C>T	c.(1015-1017)CCC>CCT	p.P339P	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	339					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			AGCCATGTCCCAACAACGTAG	0.443													96	60					0	0	0	0	T	54214631	T	T	54214631	2	4	166	1	0	0	0	0	0	0	0	1	15987	581	21	4		4	TINAG	6	54214631	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	41146	54214631	116900436	391	30719											
ZNF451	26036	broad.mit.edu	37	chr6	57006110	57006110	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatattttaggaagccacagAtgatggacataacaacaacc	17	9	7	8	0	0	2	0	1	0	1	0	4	0	4	2	2	4	0	2	2	7	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:57006110A>T	uc003pdm.1	+	8	937	c.713A>T	c.(712-714)GAT>GTT	p.D238V	ZNF451_uc003pdl.2_Missense_Mutation_p.D238V|ZNF451_uc003pdn.1_Missense_Mutation_p.D238V|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.D238V	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GAAGCCACAGATGATGGACAT	0.323													6	42					0	0	0	0	T	57006110	T	T	57006110	3	4	166	1	0	0	0	0	1	0	0	0	17989	333	12	5	743	5	ZNF451	6	57006110	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2791479	57006110	114108957	392	30720											
PRIM2	5558	broad.mit.edu	37	chr6	57512607	57512607	+	Frame_Shift_Del	DEL	A	-	-																															aacccaaaccaagtgtccagAaaaccaaggatgcatcatct																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:57512607delA	uc003pdx.2	+	15	1522	c.1435delA	c.(1435-1437)AAAfs	p.K479fs		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	479					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		AAGTGTCCAGAAAACCAAGGA	0.403													---	---	---								-	57512607	-	-	57512607	7	5	166	1	0	1	0	1	0	0	0	0	12553	247	9	0	1485	0	PRIM2	6	57512607	Frame_Shift_Del	DEL	A	TCGA-CR-7402-01A-11D-2012-08	506497	57512607	113602460	393	30721											
KHDRBS2	202559	broad.mit.edu	37	chr6	62390894	62390894	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaccataggggtgttcccTgtatccccctctggctgacc	5	12	9	15	0	2	1	0	1	2	0	4	1	4	1	5	3	1	3	5	3	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:62390894T>C	uc003peg.2	-	9	1271	c.1024A>G	c.(1024-1026)AGG>GGG	p.R342G		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		GGGTGTTCCCTGTATCCCCCT	0.498													17	32					0	0	0	0	C	62390894	C	C	62390894	3	2	166	1	0	0	0	0	1	0	0	0	8186	1579	55	5	29	5	KHDRBS2	6	62390894	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	4878287	62390894	108724173	394	30722											
COL19A1	1310	broad.mit.edu	37	chr6	70847590	70847590	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgaaagggtgaaactggacTaccaggatttccagggtctg	11	10	13	7	0	1	2	0	2	1	0	2	4	2	4	2	4	2	0	2	4	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:70847590T>A	uc003pfc.1	+	19	1514	c.1397T>A	c.(1396-1398)CTA>CAA	p.L466Q	COL19A1_uc010kam.1_Missense_Mutation_p.L362Q	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	466	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GAAACTGGACTACCAGGATTT	0.408													36	104					0	0	0	0	A	70847590	A	A	70847590	3	1	166	1	0	0	0	0	1	0	0	0	3691	1522	53	5	1467	5	COL19A1	6	70847590	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	8456696	70847590	100267477	395	30723											
COL19A1	1310	broad.mit.edu	37	chr6	70859624	70859624	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggaccagctggagagccagGtattcaggtaagctatttaa	13	9	12	7	0	1	1	1	0	0	1	1	3	1	2	2	4	3	4	2	4	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:70859624G>T	uc003pfc.1	+	28	2039	c.1922G>T	c.(1921-1923)GGT>GTT	p.G641V	COL19A1_uc010kam.1_Missense_Mutation_p.G537V	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	641	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGAGAGCCAGGTATTCAGGTA	0.383													13	34					0.00244969	0.00397796	1	0	T	70859624	T	T	70859624	3	4	166	1	0	0	0	0	1	0	0	0	3691	1261	44	4	2028	4	COL19A1	6	70859624	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	12034	70859624	100255443	396	30724											
COL12A1	1303	broad.mit.edu	37	chr6	75893061	75893061	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcttgatcccttgctaggCacaaatattttctctctgac	8	16	5	12	0	3	2	0	2	3	0	5	2	4	2	1	1	1	2	1	1	3	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:75893061C>T	uc003phs.2	-	10	1762	c.1596G>A	c.(1594-1596)GTG>GTA	p.V532V	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_Silent_p.V190V	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	532	VWFA 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CCTTGCTAGGCACAAATATTT	0.393													41	105					0	0	0	0	T	75893061	T	T	75893061	2	4	166	1	0	0	0	0	0	0	0	1	3684	697	25	4		4	COL12A1	6	75893061	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5033437	75893061	95222006	397	30725											
SNAP91	9892	broad.mit.edu	37	chr6	84350842	84350842	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttgagaaattcagacacTcgtgtcattctagttagaaa	14	12	7	8	1	3	3	2	1	1	3	4	4	3	3	1	0	0	1	1	0	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:84350842T>C	uc011dze.1	-	8	1055	c.738A>G	c.(736-738)CGA>CGG	p.R246R	SNAP91_uc003pkb.2_Silent_p.R211R|SNAP91_uc003pkc.2_Silent_p.R246R|SNAP91_uc003pkd.2_Silent_p.R246R|SNAP91_uc003pka.2_Silent_p.R246R|SNAP91_uc011dzf.1_Silent_p.R127R	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	246					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		ATTCAGACACTCGTGTCATTC	0.279													5	4					0	0	0	0	C	84350842	C	C	84350842	2	2	166	1	0	0	0	0	0	0	0	1	14897	1538	54	5		5	SNAP91	6	84350842	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	8457781	84350842	86764225	398	30726											
SNX14	57231	broad.mit.edu	37	chr6	86223949	86223949	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaacctggaaaactaccCgtcctgagaaaggatcaaat	16	6	9	10	1	1	1	1	1	0	1	2	5	2	4	3	3	3	0	3	3	6	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:86223949C>A	uc003pkr.2	-	25	2589	c.2396G>T	c.(2395-2397)CGG>CTG	p.R799L	SNX14_uc003pkp.2_Missense_Mutation_p.R662L|SNX14_uc003pkq.2_Missense_Mutation_p.R405L|SNX14_uc011dzg.1_Missense_Mutation_p.R747L|SNX14_uc003pks.2_Missense_Mutation_p.R746L|SNX14_uc003pkt.2_Missense_Mutation_p.R790L	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	799					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		GAAAACTACCCGTCCTGAGAA	0.378													24	50					3.5997e-14	7.58646e-14	1	0	A	86223949	A	A	86223949	3	1	166	1	0	0	0	0	1	0	0	0	14949	652	23	3	464	3	SNX14	6	86223949	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1873107	86223949	84891118	399	30727											
HTR1E	3354	broad.mit.edu	37	chr6	87725582	87725582	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtcagtgcaccatccagcAcgaccatgttatctacacca	12	9	6	14	1	2	0	1	0	1	0	3	1	3	0	4	0	3	3	4	0	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:87725582A>T	uc003pli.2	+	2	1233	c.530A>T	c.(529-531)CAC>CTC	p.H177L		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	177	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	ACCATCCAGCACGACCATGTT	0.522													19	69					0	0	0	0	T	87725582	T	T	87725582	3	4	166	1	0	0	0	0	1	0	0	0	7478	159	6	5	532	5	HTR1E	6	87725582	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1501633	87725582	83389485	400	30728											
PNRC1	10957	broad.mit.edu	37	chr6	89790894	89790894	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcactcctcgggcagcgcCgaagaagcggcgaaagaaga	13	2	15	11	5	0	3	0	0	0	3	2	5	1	3	2	3	2	2	2	3	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:89790894C>G	uc003pmv.2	+	1	466	c.281C>G	c.(280-282)CCG>CGG	p.P94R	PNRC1_uc003pmu.2_Missense_Mutation_p.P94R|PNRC1_uc003pmx.2_5'Flank	NM_006813	NP_006804	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	94	Nuclear localization signal.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding				0		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		CGGGCAGCGCCGAAGAAGCGG	0.721										Multiple Myeloma(7;0.094)			6	14					0	0	0	0	G	89790894	G	G	89790894	3	3	166	1	0	0	0	0	1	0	0	0	12229	652	23	3	283	3	PNRC1	6	89790894	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2065312	89790894	81324173	401	30729											
SIM1	6492	broad.mit.edu	37	chr6	100838661	100838661	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatggtcacatggtgaagtgTtggcaagagcagagccatgg	11	9	15	6	0	1	3	1	1	0	2	1	3	1	3	1	4	2	3	1	4	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:100838661T>A	uc003pqj.3	-	11	2084	c.1877A>T	c.(1876-1878)AAC>ATC	p.N626I	SIM1_uc010kcu.2_Missense_Mutation_p.N626I	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	626	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TGGTGAAGTGTTGGCAAGAGC	0.493													53	123					0	0	0	0	A	100838661	A	A	100838661	3	1	166	1	0	0	0	0	1	0	0	0	14388	1725	60	5	427	5	SIM1	6	100838661	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	11047767	100838661	70276406	402	30730											
RTN4IP1	84816	broad.mit.edu	37	chr6	107069363	107069363	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccaaggaggaactgcagcCcagacctgaaacacacacag	15	4	9	13	0	0	2	0	1	0	1	1	4	1	4	3	2	4	1	3	2	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:107069363C>T	uc003prj.2	-	3	909	c.432G>A	c.(430-432)TGG>TGA	p.W144*	RTN4IP1_uc010kdd.2_Nonsense_Mutation_p.W144*|RTN4IP1_uc003prk.2_Nonsense_Mutation_p.W44*	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	144						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		GAACTGCAGCCCAGACCTGAA	0.418													26	95					0	0	0	0	T	107069363	T	T	107069363	4	4	166	1	0	0	0	0	0	1	0	0	13794	624	22	4	786	4	RTN4IP1	6	107069363	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	6230702	107069363	64045704	403	30731											
KIAA1919	91749	broad.mit.edu	37	chr6	111587866	111587866	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcttccctgggagaaatGgctattcctgcagtcattgg	7	12	13	9	0	1	1	1	0	0	1	3	2	3	1	2	4	2	3	2	4	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:111587866G>T	uc003puv.3	+	4	1523	c.1101G>T	c.(1099-1101)ATG>ATT	p.M367I		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	367	Helical; (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		TGGGAGAAATGGCTATTCCTG	0.423													34	97					1.30988e-24	3.18531e-24	1	0	T	111587866	T	T	111587866	3	4	166	1	0	0	0	0	1	0	0	0	8301	1348	47	4	1115	4	KIAA1919	6	111587866	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4518503	111587866	59527201	404	30732											
C6orf174	387104	broad.mit.edu	37	chr6	127836029	127836029	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttccccggtctgggcgtagCggagccttttgcgctcggct	2	12	14	13	5	1	0	0	0	1	0	3	1	2	1	3	4	3	3	3	4	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:127836029C>A	uc003qbd.2	-	3	2130	c.1265G>T	c.(1264-1266)CGC>CTC	p.R422L		NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	422	Potential.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CTGGGCGTAGCGGAGCCTTTT	0.657													23	63					3.01185e-09	5.68711e-09	1	0	A	127836029	A	A	127836029	3	1	166	1	0	0	0	0	1	0	0	0	2355	768	27	3	1598	3	C6orf174	6	127836029	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	16248163	127836029	43279038	405	30733											
SAMD3	154075	broad.mit.edu	37	chr6	130535481	130535481	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatttatgaacatactcaCtctcgagctgcttctgtttg	8	15	7	11	1	3	1	1	1	2	0	4	2	3	1	1	0	4	3	1	0	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:130535481C>T	uc003qbv.2	-	5	595	c.269_splice	c.e5+1	p.D90_splice	SAMD3_uc003qbx.2_Splice_Site_p.D90_splice|SAMD3_uc003qbw.2_Splice_Site_p.D90_splice|SAMD3_uc010kfg.1_Splice_Site_p.D90_splice|SAMD3_uc003qby.2_Splice_Site_p.D90_splice|SAMD3_uc003qbz.1_Splice_Site_p.D49_splice	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform											ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		AACATACTCACTCTCGAGCTG	0.433													25	68					0	0	0	0	T	130535481	T	T	130535481	5	4	166	1	0	0	0	0	0	0	1	0	13885	579	20	4	1344	4	SAMD3	6	130535481	Splice_Site	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2699452	130535481	40579586	406	30734											
SAMD3	154075	broad.mit.edu	37	chr6	130536394	130536394	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccaccaaccaactgcagaCctgctcaactgaccaggttt	11	8	6	16	0	1	2	1	1	0	1	2	2	2	2	5	1	5	3	5	1	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:130536394C>G	uc003qbv.2	-	4	351	c.25G>C	c.(25-27)GTC>CTC	p.V9L	SAMD3_uc003qbx.2_Missense_Mutation_p.V9L|SAMD3_uc003qbw.2_Missense_Mutation_p.V9L|SAMD3_uc010kfg.1_Missense_Mutation_p.V9L|SAMD3_uc003qby.2_Missense_Mutation_p.V9L|SAMD3_uc003qbz.1_5'UTR	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	9	SAM.									ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CAACTGCAGACCTGCTCAACT	0.398													10	41					0	0	0	0	G	130536394	G	G	130536394	3	3	166	1	0	0	0	0	1	0	0	0	13885	507	18	4	1593	4	SAMD3	6	130536394	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	913	130536394	40578673	407	30735											
ENPP1	5167	broad.mit.edu	37	chr6	132172336	132172336	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagaaaaggttgaccagaaGcctctgtgcctgttcagatg	11	10	12	8	0	2	4	1	2	1	3	2	5	2	4	3	1	2	2	3	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:132172336G>T	uc011ecf.1	+	4	505	c.485G>T	c.(484-486)AGC>ATC	p.S162I		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	162	Extracellular (Potential).|SMB 2.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TTGACCAGAAGCCTCTGTGCC	0.458													32	61					2.42023e-17	5.42752e-17	1	0	T	132172336	T	T	132172336	3	4	166	1	0	0	0	0	1	0	0	0	5153	971	34	4	499	4	ENPP1	6	132172336	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1635942	132172336	38942731	408	30736											
STX7	8417	broad.mit.edu	37	chr6	132824653	132824653	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggcggggtcaccaccaactCctggagtgtaagacatggtt	9	8	14	10	1	1	1	1	0	0	1	2	2	2	2	3	5	1	2	3	5	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:132824653C>A	uc003qdg.2	-	2	267	c.17G>T	c.(16-18)GGA>GTA	p.G6V	STX7_uc011ecg.1_RNA|STX7_uc011ech.1_Missense_Mutation_p.G6V	NM_003569	NP_003560	O15400	STX7_HUMAN	syntaxin 7	6	Cytoplasmic (Potential).				intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity				0	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		ACCACCAACTCCTGGAGTGTA	0.413													31	72					4.11147e-13	8.41178e-13	1	0	A	132824653	A	A	132824653	3	1	166	1	0	0	0	0	1	0	0	0	15416	855	30	2	804	2	STX7	6	132824653	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	652317	132824653	38290414	409	30737											
VNN2	8875	broad.mit.edu	37	chr6	133072643	133072643	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cactttgggaccatttggtgCataaataccacttcctgtga	10	13	8	10	0	0	1	0	1	0	0	1	2	1	2	3	2	2	1	3	2	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:133072643C>G	uc003qdt.2	-	5	852	c.841G>C	c.(841-843)GCA>CCA	p.A281P	VNN2_uc003qds.2_5'UTR|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Missense_Mutation_p.A228P	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	281	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CCATTTGGTGCATAAATACCA	0.413													23	45					0	0	0	0	G	133072643	G	G	133072643	3	3	166	1	0	0	0	0	1	0	0	0	17251	710	25	4	733	4	VNN2	6	133072643	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	247990	133072643	38042424	410	30738											
C6orf192	116843	broad.mit.edu	37	chr6	133110904	133110904	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taatcagaaaatgacttaccCaaagagaattgtaactcctc	17	10	5	9	0	1	3	1	1	0	2	3	4	2	3	2	0	2	1	2	0	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:133110904C>G	uc003qdw.1	-	4	504	c.352G>C	c.(352-354)GGT>CGT	p.G118R	C6orf192_uc011eco.1_Missense_Mutation_p.W41S	NM_052831	NP_439896	Q6NT16	CF192_HUMAN	hypothetical protein LOC116843	118	Helical; (Potential).				transmembrane transport	integral to membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;0.00303)|GBM - Glioblastoma multiforme(226;0.0265)		ATGACTTACCCAAAGAGAATT	0.308													26	72					0	0	0	0	G	133110904	G	G	133110904	3	3	166	1	0	0	0	0	1	0	0	0	2359	608	21	4	1062	4	C6orf192	6	133110904	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	38261	133110904	38004163	411	30739											
KIAA1244	57221	broad.mit.edu	37	chr6	138576847	138576847	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctccagtccctctaccacCgagtgctgctctacccccca	6	9	6	20	1	2	0	0	0	2	0	4	1	4	0	7	0	5	3	7	0	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:138576847C>A	uc003qhu.2	+	10	1045	c.1045C>A	c.(1045-1047)CGA>AGA	p.R349R		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	349					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CCTCTACCACCGAGTGCTGCT	0.602													6	14					0.00116845	0.00191324	1	0	A	138576847	A	A	138576847	2	1	166	1	0	0	0	0	0	0	0	1	8256	644	23	3		3	KIAA1244	6	138576847	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5465943	138576847	32538220	412	30740											
ECT2L	345930	broad.mit.edu	37	chr6	139170518	139170518	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggatgggcagaaggcacAgagcatcggaatatttagcg	12	8	14	7	2	1	2	0	0	1	2	2	4	1	4	0	4	2	3	0	4	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:139170518A>C	uc003qif.1	+	7	1119	c.1016A>C	c.(1015-1017)CAG>CCG	p.Q339P	ECT2L_uc011edq.1_Missense_Mutation_p.Q270P	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	339					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						CAGAAGGCACAGAGCATCGGA	0.468													21	62					0	0	0	0	C	139170518	C	C	139170518	3	2	166	1	0	0	0	0	1	0	0	0	4924	188	7	5	1042	5	ECT2L	6	139170518	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	593671	139170518	31944549	413	30741											
PLAGL1	5325	broad.mit.edu	37	chr6	144263314	144263314	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctccggtctgcaagctctcTttcatcagctcctgtgagtg	5	14	9	13	1	5	1	2	1	3	0	8	1	6	1	2	1	3	3	2	1	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:144263314T>C	uc003qjv.2	-	3	1905	c.639A>G	c.(637-639)AAA>AAG	p.K213K	PLAGL1_uc003qjx.2_Silent_p.K213K|PLAGL1_uc003qjy.2_Silent_p.K213K|PLAGL1_uc010khl.2_Silent_p.K213K|PLAGL1_uc010khm.2_Silent_p.K213K|PLAGL1_uc003qjz.2_Silent_p.K213K|PLAGL1_uc003qka.2_Silent_p.K213K|PLAGL1_uc003qkb.2_Silent_p.K161K|PLAGL1_uc003qkc.2_Silent_p.K213K|PLAGL1_uc003qkd.2_Silent_p.K161K|PLAGL1_uc003qke.2_Silent_p.K213K|PLAGL1_uc003qkf.2_Silent_p.K213K|PLAGL1_uc003qkg.2_Silent_p.K161K|PLAGL1_uc003qkh.2_Silent_p.K213K|PLAGL1_uc003qki.2_Silent_p.K161K|PLAGL1_uc003qkj.2_Silent_p.K213K|PLAGL1_uc003qkk.2_Silent_p.K161K|PLAGL1_uc003qkl.2_Silent_p.K161K|PLAGL1_uc003qkm.2_Silent_p.K213K|PLAGL1_uc010khn.2_Silent_p.K213K|PLAGL1_uc003qkn.2_Silent_p.K161K|PLAGL1_uc003qko.2_Silent_p.K213K|PLAGL1_uc003qkp.2_Silent_p.K161K|PLAGL1_uc003qjw.2_Silent_p.K161K	NM_002656	NP_002647	Q9UM63	PLAL1_HUMAN	pleiomorphic adenoma gene-like 1 isoform 1	213					cell cycle arrest|induction of apoptosis|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.74e-07)|GBM - Glioblastoma multiforme(68;0.0885)		GCAAGCTCTCTTTCATCAGCT	0.547											OREG0017707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	107					0	0	0	0	C	144263314	C	C	144263314	2	2	166	1	0	0	0	0	0	0	0	1	12074	1606	56	5		5	PLAGL1	6	144263314	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5092796	144263314	26851753	414	30742											
PCMT1	5110	broad.mit.edu	37	chr6	150094294	150094294	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtttccaagcaacaatcagtGctccacacatggtaagttaa	14	10	7	10	0	1	0	1	0	0	0	3	0	3	0	2	1	3	5	2	1	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:150094294G>T	uc003qne.2	+	3	388	c.355G>T	c.(355-357)GCT>TCT	p.A119S	PCMT1_uc003qna.2_Missense_Mutation_p.A119S|PCMT1_uc003qnb.2_Missense_Mutation_p.A119S|PCMT1_uc011eeg.1_Missense_Mutation_p.A84S|PCMT1_uc003qnc.2_5'UTR|PCMT1_uc003qnd.2_Missense_Mutation_p.A119S|PCMT1_uc003qnf.2_Missense_Mutation_p.A119S	NM_005389	NP_005380			protein-L-isoaspartate (D-aspartate)											ovary(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.221)	OV - Ovarian serous cystadenocarcinoma(155;5.63e-13)|GBM - Glioblastoma multiforme(68;0.207)		AACAATCAGTGCTCCACACAT	0.303													20	45					6.21321e-17	1.38385e-16	1	0	T	150094294	T	T	150094294	3	4	166	1	0	0	0	0	1	0	0	0	11639	1319	46	4	365	4	PCMT1	6	150094294	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5830980	150094294	21020773	415	30743											
AKAP12	9590	broad.mit.edu	37	chr6	151670376	151670376	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctagcaagtctgcagaatctCcgactagtcccgtgaccagt	10	9	9	13	2	2	2	0	1	2	1	4	3	3	2	3	0	2	2	3	0	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:151670376C>A	uc011eep.1	+	4	1090	c.850C>A	c.(850-852)CCG>ACG	p.P284T	AKAP12_uc003qoe.2_Missense_Mutation_p.P284T|AKAP12_uc003qof.2_Missense_Mutation_p.P186T|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.P179T	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	284	Involved in PKC-binding (Probable).				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TGCAGAATCTCCGACTAGTCC	0.483													16	33					2.31682e-05	3.94524e-05	1	0	A	151670376	A	A	151670376	3	1	166	1	0	0	0	0	1	0	0	0	448	855	30	2	889	2	AKAP12	6	151670376	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1576082	151670376	19444691	416	30744											
AKAP12	9590	broad.mit.edu	37	chr6	151673277	151673277	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatacagataaagaggtgTcagtggaaactgtatccatt	15	10	10	6	0	1	2	1	0	0	2	2	3	2	3	1	2	3	2	1	2	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:151673277T>A	uc011eep.1	+	4	3991	c.3751T>A	c.(3751-3753)TCA>ACA	p.S1251T	AKAP12_uc003qoe.2_Missense_Mutation_p.S1251T|AKAP12_uc003qof.2_Missense_Mutation_p.S1153T|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.S1146T	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1251					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TAAAGAGGTGTCAGTGGAAAC	0.438													11	30					0	0	0	0	A	151673277	A	A	151673277	3	1	166	1	0	0	0	0	1	0	0	0	448	1667	58	5	3790	5	AKAP12	6	151673277	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2901	151673277	19441790	417	30745											
ESR1	2099	broad.mit.edu	37	chr6	152382208	152382208	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcggttccgcatgatgaatCtgcagggagaggagtttgtg	8	11	15	7	2	1	3	0	2	1	1	3	5	2	4	1	3	1	4	1	3	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152382208C>T	uc003qom.3	+	8	1688	c.1318C>T	c.(1318-1320)CTG>TTG	p.L440L	ESR1_uc010kin.2_Silent_p.L440L|ESR1_uc010kio.2_Silent_p.L442L|ESR1_uc010kip.2_Silent_p.L439L|ESR1_uc003qon.3_Silent_p.L440L|ESR1_uc003qoo.3_Silent_p.L440L|ESR1_uc010kiq.2_Silent_p.L38L|ESR1_uc010kir.2_Silent_p.L179L|ESR1_uc011eet.1_Intron|ESR1_uc011eeu.1_RNA|ESR1_uc011eev.1_Intron|ESR1_uc011eew.1_Intron|ESR1_uc010kis.2_Silent_p.L109L|ESR1_uc011eex.1_Intron|ESR1_uc010kit.1_3'UTR|ESR1_uc011eey.1_Silent_p.L177L	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	440	Steroid-binding.|Interaction with AKAP13.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	CATGATGAATCTGCAGGGAGA	0.413													13	15					0	0	0	0	T	152382208	T	T	152382208	2	4	166	1	0	0	0	0	0	0	0	1	5280	912	32	2		2	ESR1	6	152382208	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	708931	152382208	18732859	418	30746											
SYNE1	23345	broad.mit.edu	37	chr6	152529267	152529267	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggctgtcaatgatccccCgcctctgctgggccctgcga	4	10	11	16	2	3	1	1	1	2	0	4	2	4	1	4	2	2	2	4	2	1	0	rs149366576		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152529267C>A	uc010kiw.2	-	125	23266	c.22664G>T	c.(22663-22665)CGG>CTG	p.R7555L	SYNE1_uc010kiv.2_Missense_Mutation_p.R2079L|SYNE1_uc003qos.3_Missense_Mutation_p.R2079L|SYNE1_uc003qot.3_Missense_Mutation_p.R7484L|SYNE1_uc003qou.3_Missense_Mutation_p.R7555L|SYNE1_uc003qor.3_Missense_Mutation_p.R455L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7555	HAT 11.|Cytoplasmic (Potential).|Spectrin 25.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AATGATCCCCCGCCTCTGCTG	0.488										HNSCC(10;0.0054)			30	53					2.61193e-14	5.52253e-14	1	0	A	152529267	A	A	152529267	3	1	166	1	0	0	0	0	1	0	0	0	15511	652	23	3	3890	3	SYNE1	6	152529267	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	147059	152529267	18585800	419	30747											
SYNE1	23345	broad.mit.edu	37	chr6	152725381	152725381	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtgtttctagatttttagtTaattctttcagatcattaac	10	20	6	5	0	4	2	2	0	2	2	4	2	4	2	0	1	1	2	0	1	4	9			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152725381T>G	uc010kiw.2	-	46	7394	c.6792A>C	c.(6790-6792)TTA>TTC	p.L2264F	SYNE1_uc003qot.3_Missense_Mutation_p.L2271F|SYNE1_uc003qou.3_Missense_Mutation_p.L2264F|SYNE1_uc010kjb.1_Missense_Mutation_p.L2247F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2264	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GATTTTTAGTTAATTCTTTCA	0.328										HNSCC(10;0.0054)			40	63					0	0	0	0	G	152725381	G	G	152725381	3	3	166	1	0	0	0	0	1	0	0	0	15511	1751	61	5	20078	5	SYNE1	6	152725381	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	196114	152725381	18389686	420	30748											
SYNE1	23345	broad.mit.edu	37	chr6	152831418	152831418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccgtttacttggtgggctgGgagtctcagagctaactatg	7	13	13	8	1	1	1	1	0	1	1	3	2	2	2	1	3	3	3	1	3	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152831418G>A	uc010kiw.2	-	8	1093	c.491C>T	c.(490-492)CCC>CTC	p.P164L	SYNE1_uc003qot.3_Missense_Mutation_p.P171L|SYNE1_uc003qou.3_Missense_Mutation_p.P164L|SYNE1_uc010kjb.1_Missense_Mutation_p.P164L|SYNE1_uc003qpa.1_Missense_Mutation_p.P164L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	164	Actin-binding.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGTGGGCTGGGAGTCTCAGA	0.493										HNSCC(10;0.0054)			25	66					0	0	0	0	A	152831418	A	A	152831418	3	1	166	1	0	0	0	0	1	0	0	0	15511	1232	43	4	26531	4	SYNE1	6	152831418	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	106037	152831418	18283649	421	30749											
CNKSR3	154043	broad.mit.edu	37	chr6	154762449	154762449	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctggactgtagtggtcaggtCcaagcaaagctggataattt	11	11	12	7	0	1	0	1	0	0	0	2	2	2	2	1	4	2	3	1	4	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:154762449C>G	uc003qpy.2	-	4	989	c.484G>C	c.(484-486)GAC>CAC	p.D162H		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	162	CRIC.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		GTGGTCAGGTCCAAGCAAAGC	0.368													35	76					0	0	0	0	G	154762449	G	G	154762449	3	3	166	1	0	0	0	0	1	0	0	0	3623	855	30	2	1223	2	CNKSR3	6	154762449	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1931031	154762449	16352618	422	30750											
SERAC1	84947	broad.mit.edu	37	chr6	158569896	158569896	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agtcatatagtggatatttaCcagcaaatggattccgcagt	13	12	9	7	1	1	0	1	0	0	0	2	2	2	2	2	2	2	2	2	2	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:158569896C>G	uc003qrc.2	-	5	497	c.355_splice	c.e5+1	p.D119_splice	SERAC1_uc003qrb.2_Splice_Site	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1						GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		TGGATATTTACCAGCAAATGG	0.338													9	29					0	0	0	0	G	158569896	G	G	158569896	5	3	166	1	0	0	0	0	0	0	1	0	14139	521	18	4	1660	4	SERAC1	6	158569896	Splice_Site	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3807447	158569896	12545171	423	30751											
T	6862	broad.mit.edu	37	chr6	166571922	166571922	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccttcgtacagtggggatcCcgaggaagagggcgccgaga	9	5	16	11	4	0	2	0	0	0	2	2	6	1	4	3	4	1	1	3	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:166571922C>A	uc003quu.1	-	9	1682	c.1189G>T	c.(1189-1191)GGA>TGA	p.G397*	T_uc003qut.1_Nonsense_Mutation_p.G398*|T_uc003quv.1_Nonsense_Mutation_p.G339*	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	397					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		AGTGGGGATCCCGAGGAAGAG	0.692									Chordoma_Familial_Clustering_of				21	69					9.95505e-16	2.17282e-15	1	0	A	166571922	A	A	166571922	4	1	166	1	0	0	0	0	0	1	0	0	15554	632	22	4	122	4	T	6	166571922	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8002026	166571922	4543145	424	30752											
KIF25	3834	broad.mit.edu	37	chr6	168434642	168434642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggacgccattcggacgacgGccctgttctgccgcttgacc	5	8	13	15	5	1	1	0	1	1	0	2	4	1	3	4	3	1	2	4	3	0	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:168434642G>A	uc003qwk.1	+	4	510	c.248G>A	c.(247-249)GGC>GAC	p.G83D	KIF25_uc003qwl.1_Missense_Mutation_p.G83D	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	83	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		TCGGACGACGGCCCTGTTCTG	0.527													17	39					0	0	0	0	A	168434642	A	A	168434642	3	1	166	1	0	0	0	0	1	0	0	0	8332	1203	42	4	258	4	KIF25	6	168434642	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1862720	168434642	2680425	425	30753											
SDK1	221935	broad.mit.edu	37	chr7	4091359	4091359	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtccaccatggacacataacGaacctgaagaagtttaccgc	14	7	8	12	2	0	2	0	1	0	1	1	4	1	3	4	1	3	1	4	1	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:4091359G>C	uc003smx.2	+	19	2947	c.2808G>C	c.(2806-2808)ACG>ACC	p.T936T	SDK1_uc010kso.2_Silent_p.T212T	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	936	Fibronectin type-III 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GACACATAACGAACCTGAAGA	0.577													40	83					0	0	0	0	C	4091359	C	C	4091359	2	2	166	1	0	0	0	0	0	0	0	1	14033	1045	37	3		3	SDK1	7	4091359	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08		4091359	155047304	426	30754											
KIAA0415	9907	broad.mit.edu	37	chr7	4830976	4830976	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggccctgcgcacggtcaGccggctggtggagagggagg	5	5	19	12	3	1	1	1	0	0	1	1	3	1	2	3	7	2	2	3	7	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:4830976G>T	uc003sne.2	+	17	2467	c.2384G>T	c.(2383-2385)AGC>ATC	p.S795I	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_Missense_Mutation_p.S272I	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	795					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		CGCACGGTCAGCCGGCTGGTG	0.672													8	7					1.12685e-05	1.9425e-05	1	0	T	4830976	T	T	4830976	3	4	166	1	0	0	0	0	1	0	0	0	8214	971	34	4	2450	4	KIAA0415	7	4830976	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	739617	4830976	154307687	427	30755											
USP42	84132	broad.mit.edu	37	chr7	6189425	6189425	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacaacaagttgcctgttcGccagtgtcagtctcaaccta	10	11	7	13	1	3	0	3	0	1	0	5	0	3	0	3	0	3	2	3	0	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:6189425G>T	uc011jwo.1	+	13	1721	c.1598G>T	c.(1597-1599)CGC>CTC	p.R533L	USP42_uc010kth.1_Missense_Mutation_p.R466L|USP42_uc011jwp.1_Missense_Mutation_p.R533L|USP42_uc011jwq.1_Missense_Mutation_p.R340L|USP42_uc011jwr.1_Missense_Mutation_p.R378L	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	533					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		TTGCCTGTTCGCCAGTGTCAG	0.428													21	49					8.34094e-07	1.48351e-06	1	0	T	6189425	T	T	6189425	3	4	166	1	0	0	0	0	1	0	0	0	17141	1087	38	3	1644	3	USP42	7	6189425	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1358449	6189425	152949238	428	30756											
C1GALT1	56913	broad.mit.edu	37	chr7	7278538	7278538	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtactggaattacaactaTtatcctcctgtagaggtaag	12	13	9	7	0	0	1	0	0	0	1	2	2	2	2	2	3	3	3	2	3	8	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:7278538T>A	uc010ktn.2	+	3	1096	c.873T>A	c.(871-873)TAT>TAA	p.Y291*	C1GALT1_uc003sra.2_Nonsense_Mutation_p.Y291*|C1GALT1_uc010kto.1_Nonsense_Mutation_p.Y291*	NM_020156	NP_064541	Q9NS00	C1GLT_HUMAN	core 1 synthase,	291	Lumenal (Potential).				angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		ATTACAACTATTATCCTCCTG	0.313													10	26					0	0	0	0	A	7278538	A	A	7278538	4	1	166	1	0	0	0	0	0	1	0	0	1961	1500	52	5	879	5	C1GALT1	7	7278538	Nonsense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1089113	7278538	151860125	429	30757											
ARL4A	10124	broad.mit.edu	37	chr7	12728069	12728069	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaaaattaaggtaaccttgGgaaattctaaaacagtcact	18	10	7	6	0	2	1	1	0	1	1	2	2	2	2	1	2	2	1	1	2	7	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:12728069G>C	uc003ssp.2	+	2	467	c.190G>C	c.(190-192)GGA>CGA	p.G64R	ARL4A_uc003ssq.2_Missense_Mutation_p.G64R|ARL4A_uc003ssr.2_Missense_Mutation_p.G64R|ARL4A_uc003sss.2_Missense_Mutation_p.G64R	NM_001037164	NP_001032241	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	64					small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		GGTAACCTTGGGAAATTCTAA	0.398													12	48					0	0	0	0	C	12728069	C	C	12728069	3	2	166	1	0	0	0	0	1	0	0	0	938	1233	43	4	192	4	ARL4A	7	12728069	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5449531	12728069	146410594	430	30758											
HOXA7	3204	broad.mit.edu	37	chr7	27196162	27196162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcacataatacgaagaactCataattttgacctgtgattt	14	15	5	7	1	2	3	2	2	0	1	2	4	2	3	1	0	2	0	1	0	5	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:27196162C>T	uc003sys.2	-	1	135	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_006896	NP_008827	P31268	HXA7_HUMAN	homeobox A7	1					angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding				0						ACGAAGAACTCATAATTTTGA	0.443													30	97					0	0	0	0	T	27196162	T	T	27196162	3	4	166	1	0	0	0	0	1	0	0	0	7336	826	29	2	697	2	HOXA7	7	27196162	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	14468093	27196162	131942501	431	30759											
CCDC129	223075	broad.mit.edu	37	chr7	31682573	31682573	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgccaagaccaccacgaGgggagaatgcccaaggaaag	14	3	13	11	1	0	2	0	0	0	2	0	5	0	3	4	3	2	0	4	3	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:31682573G>A	uc003tcj.1	+	11	2582	c.1589G>A	c.(1588-1590)AGG>AAG	p.R530K	CCDC129_uc011kad.1_Missense_Mutation_p.R540K|CCDC129_uc003tci.1_Missense_Mutation_p.R381K|CCDC129_uc011kae.1_Missense_Mutation_p.R556K|CCDC129_uc003tck.1_Missense_Mutation_p.R438K	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	530											0						ACCACCACGAGGGGAGAATGC	0.547													56	125					0	0	0	0	A	31682573	A	A	31682573	3	1	166	1	0	0	0	0	1	0	0	0	2776	1000	35	4	1627	4	CCDC129	7	31682573	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4486411	31682573	127456090	432	30760											
PDE1C	5137	broad.mit.edu	37	chr7	31890356	31890356	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccagctccgtcagccagttCtgaaaggagattacagagca	12	8	10	11	1	2	3	1	1	1	2	4	4	4	3	3	1	4	3	3	1	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:31890356C>G	uc003tcm.1	-	8	1220	c.751_splice	c.e8-1	p.N251_splice	PDE1C_uc003tcn.1_Splice_Site_p.N251_splice|PDE1C_uc003tco.1_Splice_Site_p.N311_splice|PDE1C_uc003tcr.2_Splice_Site_p.N251_splice|PDE1C_uc003tcs.2_Splice_Site_p.N251_splice	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C						activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TCAGCCAGTTCTGAAAGGAGA	0.468													17	44					0	0	0	0	G	31890356	G	G	31890356	5	3	166	1	0	0	0	0	0	0	1	0	11689	927	32	2	1194	2	PDE1C	7	31890356	Splice_Site	SNP	C	TCGA-CR-7402-01A-11D-2012-08	207783	31890356	127248307	433	30761											
PDE1C	5137	broad.mit.edu	37	chr7	31917614	31917614	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caataacagctggtggatagCtcagtccaaccatgtttgat	12	11	9	9	0	1	1	1	1	0	0	2	2	2	2	2	2	4	3	2	2	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:31917614C>G	uc003tcm.1	-	5	930	c.461G>C	c.(460-462)AGC>ACC	p.S154T	PDE1C_uc003tcn.1_Missense_Mutation_p.S154T|PDE1C_uc003tco.1_Missense_Mutation_p.S214T|PDE1C_uc003tcr.2_Missense_Mutation_p.S154T|PDE1C_uc003tcs.2_Missense_Mutation_p.S154T	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	154					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TGGTGGATAGCTCAGTCCAAC	0.338													6	28					0	0	0	0	G	31917614	G	G	31917614	3	3	166	1	0	0	0	0	1	0	0	0	11689	797	28	4	1495	4	PDE1C	7	31917614	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	27258	31917614	127221049	434	30762											
AVL9	23080	broad.mit.edu	37	chr7	32590986	32590986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcaaaacttcaactcattaCacatgcatattttgaagaga	17	11	5	8	0	2	2	2	1	0	1	2	3	2	2	0	0	5	2	0	0	6	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:32590986C>T	uc003tcv.1	+	5	559	c.413C>T	c.(412-414)ACA>ATA	p.T138I	AVL9_uc011kai.1_Missense_Mutation_p.T138I|AVL9_uc010kwj.1_5'UTR	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	138						integral to membrane					0						CAACTCATTACACATGCATAT	0.308													16	102					0	0	0	0	T	32590986	T	T	32590986	3	4	166	1	0	0	0	0	1	0	0	0	1230	478	17	4	431	4	AVL9	7	32590986	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	673372	32590986	126547677	435	30763											
HERPUD2	64224	broad.mit.edu	37	chr7	35673920	35673920	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacaaaagcttcaatcacatAccatttcttcaagttccaag	15	12	3	11	0	4	0	3	0	1	0	5	0	5	0	2	0	3	2	2	0	7	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:35673920A>G	uc003tet.2	-	7	1864	c.1059_splice	c.e7+1	p.M353_splice	HERPUD2_uc003tes.3_Splice_Site_p.M353_splice	NM_022373	NP_071768	Q9BSE4	HERP2_HUMAN	HERPUD family member 2						response to unfolded protein	integral to membrane				ovary(3)	3						TCAATCACATACCATTTCTTC	0.393													12	34					0	0	0	0	G	35673920	G	G	35673920	5	3	166	1	0	0	0	0	0	0	1	0	7103	405	14	5	167	5	HERPUD2	7	35673920	Splice_Site	SNP	A	TCGA-CR-7402-01A-11D-2012-08	3082934	35673920	123464743	436	30764											
TXNDC3	51314	broad.mit.edu	37	chr7	37903047	37903047	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagaagttagtgaagaatCaccatgtgaaagtgttcgta	14	12	10	5	1	2	4	2	2	0	2	3	4	2	4	1	0	0	3	1	0	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:37903047C>A	uc003tfn.2	+	8	809	c.437C>A	c.(436-438)TCA>TAA	p.S146*		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	146					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						AGTGAAGAATCACCATGTGAA	0.348									Kartagener_syndrome				20	59					2.94398e-08	5.45388e-08	1	0	A	37903047	A	A	37903047	4	1	166	1	0	0	0	0	0	1	0	0	16866	838	29	2	459	2	TXNDC3	7	37903047	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2229127	37903047	121235616	437	30765											
TXNDC3	51314	broad.mit.edu	37	chr7	37934211	37934211	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttattggaaatgttatctGtgtaagtttctgatacataa	13	18	7	3	0	2	1	0	1	2	0	2	2	2	2	0	1	1	3	0	1	6	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:37934211G>C	uc003tfn.2	+	16	1915	c.1543G>C	c.(1543-1545)GTG>CTG	p.V515L		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	515	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						AATGTTATCTGTGTAAGTTTC	0.204									Kartagener_syndrome				5	13					0	0	0	0	C	37934211	C	C	37934211	3	2	166	1	0	0	0	0	1	0	0	0	16866	1391	48	4	1597	4	TXNDC3	7	37934211	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	31164	37934211	121204452	438	30766											
SFRP4	6424	broad.mit.edu	37	chr7	37951857	37951858	+	Missense_Mutation	DNP	CC	AG	AG																															cttgaagatctcttttacatCcaccaccgttgtgacctcat																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:37951857_37951858CC>AG	uc003tfo.3	-	4	1040_1041	c.654_655GG>CT	c.(652-657)GTGGAT>GTCTAT	p.D219Y		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	219	NTR.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						TCTTTTACATCCACCACCGTTG	0.431													18	47					0	0	0	0	AG	37951858	AG	AG	37951857	3	1	166	1	0	0	0	0	1	0	0	0	14228	855	30	2	397	2	SFRP4	7	37951857	Missense_Mutation	DNP	CC	TCGA-CR-7402-01A-11D-2012-08	17646	37951857	121186806	439	30767											
C7orf10	79783	broad.mit.edu	37	chr7	40234623	40234623	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgggatatgaagatatagacGagattgctcctcacatcatc	13	11	9	8	1	2	4	2	1	0	3	4	6	3	5	1	1	1	1	1	1	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:40234623G>C	uc003thn.1	+	6	493	c.448G>C	c.(448-450)GAG>CAG	p.E150Q	C7orf10_uc003thm.1_Intron|C7orf10_uc003tho.1_Missense_Mutation_p.E150Q	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	157							transferase activity			ovary(2)	2						AGATATAGACGAGATTGCTCC	0.428													44	138					0	0	0	0	C	40234623	C	C	40234623	3	2	166	1	0	0	0	0	1	0	0	0	2387	1073	37	3		3	C7orf10	7	40234623	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2282766	40234623	118904040	440	30768											
C7orf10	79783	broad.mit.edu	37	chr7	40498771	40498771	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttcgggtacacaatagaaaAgagcttattaaaatattatc	17	12	6	6	1	0	2	0	0	0	2	2	2	0	2	0	1	2	2	0	1	10	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:40498771A>G	uc003thn.1	+	11	1005	c.960A>G	c.(958-960)AAA>AAG	p.K320K	C7orf10_uc003thm.1_Silent_p.K290K|C7orf10_uc003tho.1_Silent_p.K272K	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	327							transferase activity			ovary(2)	2						ACAATAGAAAAGAGCTTATTA	0.279													7	31					0	0	0	0	G	40498771	G	G	40498771	2	3	166	1	0	0	0	0	0	0	0	1	2387	69	3	5		5	C7orf10	7	40498771	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	264148	40498771	118639892	441	30769											
GLI3	2737	broad.mit.edu	37	chr7	42005670	42005670	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgctggccctcctcacgcCgtggcccggcgcatcgtgcg	2	7	14	18	7	1	0	1	0	0	0	4	0	2	0	4	3	1	2	4	3	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:42005670C>A	uc011kbh.1	-	15	3092	c.3001G>T	c.(3001-3003)GGC>TGC	p.G1001C	GLI3_uc011kbg.1_Missense_Mutation_p.G942C	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1001					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTCCTCACGCCGTGGCCCGGC	0.756									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				8	10					0.000274275	0.000453271	1	0	A	42005670	A	A	42005670	3	1	166	1	0	0	0	0	1	0	0	0	6476	652	23	3	1745	3	GLI3	7	42005670	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1506899	42005670	117132993	442	30770											
TNS3	64759	broad.mit.edu	37	chr7	47408665	47408665	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatcttcaccaacgttgctGccaaaaccgtcagataggag	12	8	10	11	2	3	1	2	0	1	1	3	3	3	3	3	2	4	2	3	2	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:47408665G>T	uc003tnv.2	-	17	1945	c.1578C>A	c.(1576-1578)GGC>GGA	p.G526G	TNS3_uc003tnw.2_Silent_p.G526G	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	526						focal adhesion	protein binding			ovary(4)	4						CAACGTTGCTGCCAAAACCGT	0.627													21	30					1.2644e-06	2.24502e-06	1	0	T	47408665	T	T	47408665	2	4	166	1	0	0	0	0	0	0	0	1	16410	1306	46	4		4	TNS3	7	47408665	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5402995	47408665	111729998	443	30771											
TNS3	64759	broad.mit.edu	37	chr7	47474985	47474985	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcggtgcgtggagctctggCcagcccacatccatgatctg	6	8	14	13	2	2	1	0	1	2	0	3	2	3	2	3	4	3	1	3	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:47474985C>T	uc003tnv.2	-	8	586	c.219G>A	c.(217-219)TGG>TGA	p.W73*	TNS3_uc003tnw.2_Nonsense_Mutation_p.W73*|TNS3_uc010kyo.1_Nonsense_Mutation_p.W73*	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	73	Phosphatase tensin-type.					focal adhesion	protein binding			ovary(4)	4						GGAGCTCTGGCCAGCCCACAT	0.517													25	81					0	0	0	0	T	47474985	T	T	47474985	4	4	166	1	0	0	0	0	0	1	0	0	16410	740	26	4	4214	4	TNS3	7	47474985	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	66320	47474985	111663678	444	30772											
C7orf57	136288	broad.mit.edu	37	chr7	48080958	48080958	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaccacgtcccagtgaagcGctctgagaaggccgtggatg	9	8	13	11	3	1	2	0	2	1	1	2	4	2	3	3	2	2	1	3	2	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:48080958G>T	uc003toh.3	+	3	295	c.83G>T	c.(82-84)CGC>CTC	p.R28L	C7orf57_uc003toi.3_5'UTR	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	28										ovary(1)	1						CCAGTGAAGCGCTCTGAGAAG	0.582													10	43					2.80697e-09	5.31049e-09	1	0	T	48080958	T	T	48080958	3	4	166	1	0	0	0	0	1	0	0	0	2415	1087	38	3	89	3	C7orf57	7	48080958	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	605973	48080958	111057705	445	30773											
ABCA13	154664	broad.mit.edu	37	chr7	48443395	48443395	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgggcatgtcgaggaccGtggttctggatgagcccacc	7	9	14	11	2	2	1	1	1	1	0	3	4	2	3	3	4	1	2	3	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:48443395G>T	uc003toq.2	+	39	12014	c.11989G>T	c.(11989-11991)GTG>TTG	p.V3997L	ABCA13_uc010kys.1_Missense_Mutation_p.V1071L|ABCA13_uc003tos.1_Missense_Mutation_p.V823L|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3997	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GTCGAGGACCGTGGTTCTGGA	0.572													9	25					1.76689e-08	3.2888e-08	1	0	T	48443395	T	T	48443395	3	4	166	1	0	0	0	0	1	0	0	0	31	1145	40	3	11972	3	ABCA13	7	48443395	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	362437	48443395	110695268	446	30774											
ABCA13	154664	broad.mit.edu	37	chr7	48619833	48619833	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcagagacgccgtggacCtgtcttctgctggcacggca	6	9	13	13	3	3	1	0	0	3	1	3	3	3	2	2	3	2	4	2	3	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:48619833C>A	uc003toq.2	+	56	14393	c.14368C>A	c.(14368-14370)CTG>ATG	p.L4790M	ABCA13_uc010kys.1_Missense_Mutation_p.L1865M|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Missense_Mutation_p.L520M	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4790	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CGCCGTGGACCTGTCTTCTGC	0.522													4	8					2.7689e-08	5.14411e-08	1	0	A	48619833	A	A	48619833	3	1	166	1	0	0	0	0	1	0	0	0	31	680	24	4	14419	4	ABCA13	7	48619833	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	176438	48619833	110518830	447	30775											
ZPBP	11055	broad.mit.edu	37	chr7	50070687	50070687	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	taacaaattgtatagacttaCctgaaaatgcaaagaacaat	20	10	5	6	0	0	3	0	1	0	2	0	3	0	3	1	0	4	2	1	0	10	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:50070687C>A	uc003tou.2	-	5	776	c.706_splice	c.e5+1	p.V236_splice	ZPBP_uc011kci.1_Splice_Site_p.V162_splice|ZPBP_uc010kyw.2_Splice_Site_p.V235_splice	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1						binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					TATAGACTTACCTGAAAATGC	0.299													4	52					0.000602214	0.00099105	1	0	A	50070687	A	A	50070687	5	1	166	1	0	0	0	0	0	0	1	0	18286	521	18	4	364	4	ZPBP	7	50070687	Splice_Site	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1450854	50070687	109067976	448	30776											
COBL	23242	broad.mit.edu	37	chr7	51261227	51261227	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgaatttcaagggcatggTgggatggattcaggtggttc	9	11	15	6	1	2	0	2	0	0	0	3	3	2	2	1	6	0	2	1	6	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:51261227T>A	uc003tpr.3	-	3	490	c.305A>T	c.(304-306)CAC>CTC	p.H102L	COBL_uc003tps.2_Missense_Mutation_p.H102L|COBL_uc011kcl.1_Missense_Mutation_p.H102L|COBL_uc010kzc.2_Missense_Mutation_p.H102L|COBL_uc003tpt.2_Missense_Mutation_p.H102L|COBL_uc003tpp.3_5'Flank|COBL_uc003tpq.3_Missense_Mutation_p.H18L	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	102										skin(3)|ovary(2)	5	Glioma(55;0.08)					AAGGGCATGGTGGGATGGATT	0.413													10	45					0	0	0	0	A	51261227	A	A	51261227	3	1	166	1	0	0	0	0	1	0	0	0	3668	1696	59	5	3524	5	COBL	7	51261227	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1190540	51261227	107877436	449	30777											
ZNF479	90827	broad.mit.edu	37	chr7	57188157	57188157	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcacacctgcagggtttcTctccagtatgaattctcttg	7	14	7	13	0	3	1	1	1	2	0	6	1	4	1	3	1	1	3	3	1	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:57188157T>G	uc010kzo.2	-	5	1236	c.965A>C	c.(964-966)GAG>GCG	p.E322A		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			GCAGGGTTTCTCTCCAGTATG	0.443													15	37					0	0	0	0	G	57188157	G	G	57188157	3	3	166	1	0	0	0	0	1	0	0	0	18000	1551	54	5	613	5	ZNF479	7	57188157	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5926930	57188157	101950506	450	30778											
ZNF716	441234	broad.mit.edu	37	chr7	57529257	57529257	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggaaagcctttaccttcTcctcaactctaaatactcat	11	13	5	12	0	4	0	2	0	2	0	5	1	4	1	3	1	4	0	3	1	6	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:57529257T>C	uc011kdi.1	+	4	1202	c.1090T>C	c.(1090-1092)TCC>CCC	p.S364P		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						CTTTACCTTCTCCTCAACTCT	0.403													8	22					0	0	0	0	C	57529257	C	C	57529257	3	2	166	1	0	0	0	0	1	0	0	0	18186	1551	54	5	1104	5	ZNF716	7	57529257	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	341100	57529257	101609406	451	30779											
ZNF107	51427	broad.mit.edu	37	chr7	64166767	64166767	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaagattctttccagaaaGtgacactgagaagatacgga	17	9	9	6	1	1	5	0	2	1	4	2	7	2	6	1	1	1	0	1	1	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:64166767G>T	uc003ttd.2	+	7	871	c.85G>T	c.(85-87)GTG>TTG	p.V29L	ZNF107_uc003tte.2_Missense_Mutation_p.V29L	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TTTCCAGAAAGTGACACTGAG	0.358													14	17					1.5842e-08	2.95436e-08	1	0	T	64166767	T	T	64166767	3	4	166	1	0	0	0	0	1	0	0	0	17782	1029	36	4	91	4	ZNF107	7	64166767	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	6637510	64166767	94971896	452	30780											
ZNF92	168374	broad.mit.edu	37	chr7	64863788	64863788	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaataattcatactggagAgaaaccctacaaatgtgaag	19	9	7	6	0	1	2	1	1	0	1	1	4	1	3	1	1	3	0	1	1	8	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:64863788A>G	uc003ttz.2	+	4	904	c.761A>G	c.(760-762)GAG>GGG	p.E254G	ZNF92_uc003tua.2_Missense_Mutation_p.E185G|ZNF92_uc010kzu.2_Missense_Mutation_p.E222G|ZNF92_uc003tub.2_Missense_Mutation_p.E178G	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	254						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)				CATACTGGAGAGAAACCCTAC	0.348													27	36					0	0	0	0	G	64863788	G	G	64863788	3	3	166	1	0	0	0	0	1	0	0	0	18268	304	11	5	775	5	ZNF92	7	64863788	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	697021	64863788	94274875	453	30781											
WBSCR17	64409	broad.mit.edu	37	chr7	71036356	71036356	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatcctggcatggatgtatAcggaggagaaaatattgaac	14	9	13	5	1	0	2	0	1	0	1	1	6	1	5	1	5	2	2	1	5	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:71036356A>G	uc003tvy.2	+	6	1049	c.1049A>G	c.(1048-1050)TAC>TGC	p.Y350C	WBSCR17_uc003tvz.2_Missense_Mutation_p.Y49C	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	350	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				ATGGATGTATACGGAGGAGAA	0.512													29	76					0	0	0	0	G	71036356	G	G	71036356	3	3	166	1	0	0	0	0	1	0	0	0	17332	391	14	5	1071	5	WBSCR17	7	71036356	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	6172568	71036356	88102307	454	30782											
WBSCR28	135886	broad.mit.edu	37	chr7	73279506	73279506	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgggctggctctgatacagGtccccgtatggctggtgcta	5	11	14	11	1	1	1	0	1	1	0	2	1	2	1	2	5	2	5	2	5	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:73279506G>T	uc003tzk.2	+	2	292	c.256G>T	c.(256-258)GTC>TTC	p.V86F	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_5'UTR	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	86	Helical; (Potential).					integral to membrane				breast(1)	1		Lung NSC(55;0.159)				TCTGATACAGGTCCCCGTATG	0.692													34	75					4.02929e-09	7.60096e-09	1	0	T	73279506	T	T	73279506	3	4	166	1	0	0	0	0	1	0	0	0	17335	1261	44	4	262	4	WBSCR28	7	73279506	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2243150	73279506	85859157	455	30783											
GTF2IRD1	9569	broad.mit.edu	37	chr7	73969543	73969543	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagtcaaagagcccatcatGgatagtcaaggtacccagcg	13	6	12	10	1	3	1	3	0	0	1	3	3	3	3	2	3	3	1	2	3	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:73969543G>T	uc003uaq.2	+	18	2349	c.1956G>T	c.(1954-1956)ATG>ATT	p.M652I	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.M684I|GTF2IRD1_uc003uap.2_Silent_p.V652V|GTF2IRD1_uc003uar.1_Missense_Mutation_p.M652I	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	652						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						AGCCCATCATGGATAGTCAAG	0.637													23	57					2.89027e-11	5.72215e-11	1	0	T	73969543	T	T	73969543	3	4	166	1	0	0	0	0	1	0	0	0	6907	1348	47	4	2022	4	GTF2IRD1	7	73969543	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	690037	73969543	85169120	456	30784											
PCLO	27445	broad.mit.edu	37	chr7	82451863	82451863	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcggcagcagctatggcagcCcctgcatcttccaggtgggt	6	9	13	13	1	1	0	0	0	1	0	3	0	2	0	3	4	4	5	3	4	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:82451863C>A	uc003uhx.2	-	20	15028	c.14739G>T	c.(14737-14739)GGG>GGT	p.G4913G	PCLO_uc003uhv.2_Silent_p.G4913G|PCLO_uc003uht.1_Silent_p.G355G|PCLO_uc003uhu.1_Silent_p.G334G	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4775					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTATGGCAGCCCCTGCATCTT	0.498													71	176					3.31162e-33	8.27904e-33	1	0	A	82451863	A	A	82451863	2	1	166	1	0	0	0	0	0	0	0	1	11637	610	22	4		4	PCLO	7	82451863	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8482320	82451863	76686800	457	30785											
ABCB1	5243	broad.mit.edu	37	chr7	87160614	87160614	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atttagtttgactcaccttcCcagaaccttctagttctttc	8	17	4	12	0	3	2	1	1	2	1	5	2	4	2	3	0	1	2	3	0	3	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:87160614C>G	uc003uiz.1	-	22	3099	c.2681G>C	c.(2680-2682)GGG>GCG	p.G894A	ABCB1_uc011khc.1_Missense_Mutation_p.G830A	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	894	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ACTCACCTTCCCAGAACCTTC	0.343													23	36					0	0	0	0	G	87160614	G	G	87160614	3	3	166	1	0	0	0	0	1	0	0	0	40	623	22	4	1193	4	ABCB1	7	87160614	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4708751	87160614	71978049	458	30786											
PEX1	5189	broad.mit.edu	37	chr7	92134134	92134134	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatgaggtcaaggtcatcCagcaggacaacagatggctg	13	6	13	9	0	2	2	2	1	0	1	3	3	3	3	1	4	2	3	1	4	3	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:92134134C>A	uc003uly.2	-	12	2079	c.1983G>T	c.(1981-1983)CTG>CTT	p.L661L	PEX1_uc011khr.1_Silent_p.L453L|PEX1_uc010ley.2_Intron|PEX1_uc011khs.1_Silent_p.L339L|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	661			Missing (in NALD).		microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CAAGGTCATCCAGCAGGACAA	0.502													30	84					3.57733e-08	6.60845e-08	1	0	A	92134134	A	A	92134134	2	1	166	1	0	0	0	0	0	0	0	1	11790	581	21	4		4	PEX1	7	92134134	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4973520	92134134	67004529	459	30787											
PON1	5444	broad.mit.edu	37	chr7	94944746	94944746	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcattcaggtccatcagAagtatttttccaggactgtt	9	16	7	9	0	4	1	3	0	1	1	6	2	6	2	2	2	0	2	2	2	2	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:94944746A>G	uc003uns.2	-	4	355	c.258T>C	c.(256-258)CTT>CTC	p.L86L	PON1_uc011kih.1_Silent_p.L86L	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	86					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	GGTCCATCAGAAGTATTTTTC	0.388													20	55					0	0	0	0	G	94944746	G	G	94944746	2	3	166	1	0	0	0	0	0	0	0	1	12303	233	9	5		5	PON1	7	94944746	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2810612	94944746	64193917	460	30788											
ZNF789	285989	broad.mit.edu	37	chr7	99084446	99084446	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagtcttatgaatgcagtGaatgtggaaaagtcattagg	15	11	11	4	0	2	2	1	2	1	0	2	3	2	3	0	2	1	1	0	2	7	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99084446G>C	uc003uqq.1	+	5	832	c.613G>C	c.(613-615)GAA>CAA	p.E205Q	ZNF789_uc010lfw.1_Missense_Mutation_p.E110Q|ZNF789_uc003uqr.1_Missense_Mutation_p.E147Q	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	zinc finger protein 789 isoform 1	205	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGAATGCAGTGAATGTGGAAA	0.418													34	55					0	0	0	0	C	99084446	C	C	99084446	3	2	166	1	0	0	0	0	1	0	0	0	18227	1291	45	2	669	2	ZNF789	7	99084446	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4139700	99084446	60054217	461	30789											
ZNF394	84124	broad.mit.edu	37	chr7	99097390	99097390	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatggtgaggaactgctcCagcaccagcagctccaggat	11	6	13	11	0	0	1	0	1	0	0	2	4	2	4	3	4	5	4	3	4	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99097390C>T	uc003uqs.2	-	1	488	c.327G>A	c.(325-327)CTG>CTA	p.L109L	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Silent_p.L109L	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	109	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGAACTGCTCCAGCACCAGCA	0.672													5	134					0	0	0	0	T	99097390	T	T	99097390	2	4	166	1	0	0	0	0	0	0	0	1	17947	581	21	4		4	ZNF394	7	99097390	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	12944	99097390	60041273	462	30790											
ZKSCAN5	23660	broad.mit.edu	37	chr7	99124011	99124011	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgcatctgatcgaacacctaAaacgccacttcagggagaaa	15	6	8	12	3	2	2	1	1	1	1	3	4	2	2	2	1	2	1	2	1	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99124011A>C	uc003uqv.2	+	6	1472	c.1348A>C	c.(1348-1350)AAA>CAA	p.K450Q	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.K450Q|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.K450Q|ZKSCAN5_uc003uqx.2_Missense_Mutation_p.K377Q|ZKSCAN5_uc003uqy.2_Missense_Mutation_p.K186Q	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	450	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CGAACACCTAAAACGCCACTT	0.502													79	190					0	0	0	0	C	99124011	C	C	99124011	3	2	166	1	0	0	0	0	1	0	0	0	17757	15	1	5	1366	5	ZKSCAN5	7	99124011	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	26621	99124011	60014652	463	30791											
ZNF655	79027	broad.mit.edu	37	chr7	99170651	99170651	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaatcttacaaatgtagcaGttgtgaaagagtcttcagtc	14	12	8	7	0	3	2	1	1	2	1	4	2	3	2	0	0	2	3	0	0	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99170651G>C	uc003urh.2	+	3	1313	c.920G>C	c.(919-921)AGT>ACT	p.S307T	ZNF655_uc010lga.2_Missense_Mutation_p.S342T|ZNF655_uc010lgc.2_Missense_Mutation_p.S342T|ZNF655_uc003urj.2_Missense_Mutation_p.S307T|ZNF655_uc003urk.2_Missense_Mutation_p.S144T|ZNF655_uc010lgd.2_Missense_Mutation_p.S144T	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	307	C2H2-type 3.				G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					AAATGTAGCAGTTGTGAAAGA	0.413													20	52					0	0	0	0	C	99170651	C	C	99170651	3	2	166	1	0	0	0	0	1	0	0	0	18135	1029	36	4	1457	4	ZNF655	7	99170651	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	46640	99170651	59968012	464	30792											
TFR2	7036	broad.mit.edu	37	chr7	100225246	100225246	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactcccacaaaggccgtgAaggaataggcactgctgtcc	11	6	12	12	1	0	1	0	1	0	0	2	3	2	3	3	4	1	2	3	4	4	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:100225246A>T	uc003uvv.1	-	15	1762	c.1721T>A	c.(1720-1722)TTC>TAC	p.F574Y	TFR2_uc010lhc.1_Missense_Mutation_p.F115Y|TFR2_uc003uvu.1_Missense_Mutation_p.F403Y	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2	574	Extracellular (Potential).				cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					AAAGGCCGTGAAGGAATAGGC	0.632													9	39					0	0	0	0	T	100225246	T	T	100225246	3	4	166	1	0	0	0	0	1	0	0	0	15877	246	9	5	700	5	TFR2	7	100225246	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1054595	100225246	58913417	465	30793											
MUC17	140453	broad.mit.edu	37	chr7	100676773	100676773	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaagcactccattaacaagTatgcctgtcaacaccacact	14	8	6	13	0	1	0	1	0	0	0	2	1	2	1	3	1	4	2	3	1	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:100676773T>C	uc003uxp.1	+	3	2129	c.2076T>C	c.(2074-2076)AGT>AGC	p.S692S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	692	Extracellular (Potential).|9.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CATTAACAAGTATGCCTGTCA	0.493													213	468					0	0	0	0	C	100676773	C	C	100676773	2	2	166	1	0	0	0	0	0	0	0	1	10027	1635	57	5		5	MUC17	7	100676773	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	451527	100676773	58461890	466	30794											
RELN	5649	broad.mit.edu	37	chr7	103292197	103292197	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cattcagtgtgaaggagggaCcaggagcgcccatggttggt	9	8	16	8	1	1	1	1	1	0	0	1	4	1	4	2	5	1	1	2	5	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:103292197C>G	uc003vca.2	-	15	1963	c.1803G>C	c.(1801-1803)TGG>TGC	p.W601C	RELN_uc010liz.2_Missense_Mutation_p.W601C	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	601	BNR 1.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GAAGGAGGGACCAGGAGCGCC	0.478													14	32					0	0	0	0	G	103292197	G	G	103292197	3	3	166	1	0	0	0	0	1	0	0	0	13285	508	18	4	8783	4	RELN	7	103292197	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2615424	103292197	55846466	467	30795											
RINT1	60561	broad.mit.edu	37	chr7	105204333	105204334	+	Missense_Mutation	DNP	CG	TA	TA																															taaagcatgatatgttgaccCgtcaagtagaccacgttttt																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:105204333_105204334CG>TA	uc003vda.1	+	12	2056_2057	c.1825_1826CG>TA	c.(1825-1827)CGT>TAT	p.R609Y	RINT1_uc010ljj.1_Missense_Mutation_p.R184Y	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	609	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						TATGTTGACCCGTCAAGTAGAC	0.386													12	43					0	0	0	0	TA	105204334	TA	TA	105204333	3	4	166	1	0	0	0	0	1	0	0	0	13441	652	23	1	1871	1	RINT1	7	105204333	Missense_Mutation	DNP	CG	TCGA-CR-7402-01A-11D-2012-08	1912136	105204333	53934330	468	30796											
LAMB4	22798	broad.mit.edu	37	chr7	107746424	107746424	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccaagcaaagcatccccAagggtgtggagcttggtaaa	12	8	11	10	0	0	0	0	0	0	0	2	1	2	1	3	3	3	4	3	3	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:107746424A>G	uc010ljo.1	-	8	792	c.708T>C	c.(706-708)CTT>CTC	p.L236L	LAMB4_uc003vey.2_Silent_p.L236L	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	236	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						AAGCATCCCCAAGGGTGTGGA	0.418													16	42					0	0	0	0	G	107746424	G	G	107746424	2	3	166	1	0	0	0	0	0	0	0	1	8653	117	5	5		5	LAMB4	7	107746424	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2542091	107746424	51392239	469	30797											
LRRN3	54674	broad.mit.edu	37	chr7	110762957	110762957	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaggccttggtttacaccCagatccatttatatggaagc	11	12	8	10	0	1	1	1	0	0	1	2	2	2	2	3	3	2	1	3	3	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:110762957C>A	uc003vft.3	+	4	1175	c.129C>A	c.(127-129)CCC>CCA	p.P43P	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Silent_p.P43P|LRRN3_uc003vfs.3_Silent_p.P43P	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	43	Extracellular (Potential).|LRRNT.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		GGTTTACACCCAGATCCATTT	0.413													27	80					1.26454e-06	2.24502e-06	1	0	A	110762957	A	A	110762957	2	1	166	1	0	0	0	0	0	0	0	1	9086	581	21	4		4	LRRN3	7	110762957	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3016533	110762957	48375706	470	30798											
ASZ1	136991	broad.mit.edu	37	chr7	117023080	117023080	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctatcagaatctgttgtcaAtattttacaaatagtgtctt	12	18	5	6	0	5	1	2	0	3	1	5	1	5	1	0	0	1	1	0	0	7	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:117023080A>T	uc003vjb.2	-	7	835	c.772T>A	c.(772-774)TTG>ATG	p.L258M	ASZ1_uc011kno.1_Missense_Mutation_p.L258M|ASZ1_uc011knp.1_Missense_Mutation_p.L50M	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	258					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TCTGTTGTCAATATTTTACAA	0.259													12	46					0	0	0	0	T	117023080	T	T	117023080	3	4	166	1	0	0	0	0	1	0	0	0	1071	98	4	5	683	5	ASZ1	7	117023080	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	6260123	117023080	42115583	471	30799											
CFTR	1080	broad.mit.edu	37	chr7	117246788	117246788	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggatgaccttctgcctcttaCcatatttgacttcatccagg	8	14	7	12	0	3	2	1	2	2	0	4	3	4	3	4	2	2	0	4	2	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:117246788C>A	uc003vjd.2	+	18	3101	c.2969C>A	c.(2968-2970)ACC>AAC	p.T990N	CFTR_uc011knq.1_Missense_Mutation_p.T396N	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	990	Cytoplasmic (Potential).|ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CTGCCTCTTACCATATTTGAC	0.289									Cystic_Fibrosis				23	89					3.28513e-13	6.7352e-13	1	0	A	117246788	A	A	117246788	3	1	166	1	0	0	0	0	1	0	0	0	3309	507	18	4	3039	4	CFTR	7	117246788	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	223708	117246788	41891875	472	30800											
HYAL4	23553	broad.mit.edu	37	chr7	123508735	123508735	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aattattacatccctgctgaAgatttcagtggacttgctgt	10	15	8	8	0	1	2	1	1	0	1	2	3	2	3	1	1	3	2	1	1	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:123508735A>G	uc003vlc.2	+	3	1046	c.408A>G	c.(406-408)GAA>GAG	p.E136E	HYAL4_uc011knz.1_Silent_p.E136E	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	136	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						TCCCTGCTGAAGATTTCAGTG	0.428													19	63					0	0	0	0	G	123508735	G	G	123508735	2	3	166	1	0	0	0	0	0	0	0	1	7505	69	3	5		5	HYAL4	7	123508735	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	6261947	123508735	35629928	473	30801											
GCC1	79571	broad.mit.edu	37	chr7	127223058	127223058	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcacctggcttttcctggcCgcaacctgcagcagcctctt	5	11	9	16	1	2	0	1	0	1	0	3	0	3	0	5	2	4	4	5	2	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:127223058C>T	uc003vma.2	-	2	1756	c.1338G>A	c.(1336-1338)GCG>GCA	p.A446A		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	446	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						TTTTCCTGGCCGCAACCTGCA	0.557													45	132					0	0	0	0	T	127223058	T	T	127223058	2	4	166	1	0	0	0	0	0	0	0	1	6320	639	23	1		1	GCC1	7	127223058	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3714323	127223058	31915605	474	30802											
DGKI	9162	broad.mit.edu	37	chr7	137237200	137237200	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggagatccgaatcatagctgGggccaacctacagggctccc	10	6	12	13	1	1	1	1	0	0	1	3	3	3	1	4	4	3	2	4	4	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:137237200G>T	uc003vtt.2	-	20	2063	c.2062C>A	c.(2062-2064)CCA>ACA	p.P688T	DGKI_uc003vtu.2_Missense_Mutation_p.P388T	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	688					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						ATCATAGCTGGGGCCAACCTA	0.517													40	98					6.04917e-29	1.49137e-28	1	0	T	137237200	T	T	137237200	3	4	166	1	0	0	0	0	1	0	0	0	4493	1232	43	4	1195	4	DGKI	7	137237200	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	10014142	137237200	21901463	475	30803											
DGKI	9162	broad.mit.edu	37	chr7	137271843	137271843	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccccgagagcagttcttacCcctccccagttgagagttcg	7	10	9	15	2	1	2	0	1	1	2	4	4	3	2	6	0	2	4	6	0	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:137271843C>A	uc003vtt.2	-	13	1426	c.1425G>T	c.(1423-1425)GGG>GGT	p.G475G	DGKI_uc003vtu.2_Silent_p.G175G	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	475	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CAGTTCTTACCCCTCCCCAGT	0.552													18	54					5.3912e-06	9.37601e-06	1	0	A	137271843	A	A	137271843	2	1	166	1	0	0	0	0	0	0	0	1	4493	637	22	4		4	DGKI	7	137271843	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	34643	137271843	21866820	476	30804											
PARP12	64761	broad.mit.edu	37	chr7	139756947	139756947	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctcctttgttgtaatgttGgcaaatctgttgacagagag	10	15	10	6	0	2	2	0	1	2	1	3	3	2	2	1	1	0	5	1	1	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:139756947G>A	uc003vvl.1	-	3	1343	c.469C>T	c.(469-471)CAA>TAA	p.Q157*	PARP12_uc003vvk.1_5'UTR|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	157	C3H1-type 2.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					TTGTAATGTTGGCAAATCTGT	0.498													30	76					0	0	0	0	A	139756947	A	A	139756947	4	1	166	1	0	0	0	0	0	1	0	0	11511	1357	47	4	1676	4	PARP12	7	139756947	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2485104	139756947	19381716	477	30805											
DENND2A	27147	broad.mit.edu	37	chr7	140244499	140244499	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccaggtggcggacgctgaggGaggagaagagagactcaaag	13	3	18	7	2	1	4	1	1	0	3	1	8	1	6	1	5	0	1	1	5	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:140244499G>C	uc010lnj.2	-	12	2391	c.2246C>G	c.(2245-2247)TCC>TGC	p.S749C	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.S749C|DENND2A_uc003vvw.2_Missense_Mutation_p.S749C|DENND2A_uc003vvx.2_Missense_Mutation_p.S749C	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	749	DENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GACGCTGAGGGAGGAGAAGAG	0.602													8	25					0	0	0	0	C	140244499	C	C	140244499	3	2	166	1	0	0	0	0	1	0	0	0	4451	1174	41	2	811	2	DENND2A	7	140244499	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	487552	140244499	18894164	478	30806											
TAS2R38	5726	broad.mit.edu	37	chr7	141673292	141673292	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggaacagcagtccatgcagGaaaagccggctgatgctgag	13	5	14	9	1	0	2	0	2	0	0	1	4	1	4	2	3	5	4	2	3	3	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:141673292G>T	uc003vwx.1	-	1	282	c.198C>A	c.(196-198)TTC>TTA	p.F66L		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	66	Helical; Name=2; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					GTCCATGCAGGAAAAGCCGGC	0.493													37	85					2.42023e-17	5.42752e-17	1	0	T	141673292	T	T	141673292	3	4	166	1	0	0	0	0	1	0	0	0	15641	1165	41	2	807	2	TAS2R38	7	141673292	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1428793	141673292	17465371	479	30807											
TAS2R40	259286	broad.mit.edu	37	chr7	142919319	142919319	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atggggctgagtgggccaggGgcaaaacactccccactggt	9	6	15	11	0	0	1	0	1	0	0	1	1	1	1	3	6	1	2	3	6	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:142919319G>C	uc011ksx.1	+	1	148	c.148G>C	c.(148-150)GGC>CGC	p.G50R		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	50	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					GTGGGCCAGGGGCAAAACACT	0.522													23	66					0	0	0	0	C	142919319	C	C	142919319	3	2	166	1	0	0	0	0	1	0	0	0	15644	1232	43	4	150	4	TAS2R40	7	142919319	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1246027	142919319	16219344	480	30808											
OR2F1	26211	broad.mit.edu	37	chr7	143657134	143657134	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccagtgactgggacactcGggtctccctgtttgtcctgt	4	13	12	12	1	1	1	0	1	1	0	5	2	3	2	3	2	0	1	3	2	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143657134G>T	uc003wds.1	+	1	115	c.71G>T	c.(70-72)CGG>CTG	p.R24L		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					TGGGACACTCGGGTCTCCCTG	0.473													80	142					1.45978e-39	3.68233e-39	1	0	T	143657134	T	T	143657134	3	4	166	1	0	0	0	0	1	0	0	0	11050	1116	39	3	73	3	OR2F1	7	143657134	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	737815	143657134	15481529	481	30809											
OR2A5	393046	broad.mit.edu	37	chr7	143747689	143747689	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacttctttctctcacacctGgccatcattgatatttcgta	8	17	4	12	1	4	1	2	1	2	0	6	1	4	1	2	1	1	1	2	1	3	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143747689G>T	uc011ktw.1	+	1	195	c.195G>T	c.(193-195)CTG>CTT	p.L65L		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TCTCACACCTGGCCATCATTG	0.488													18	77					3.52763e-06	6.16235e-06	1	0	T	143747689	T	T	143747689	2	4	166	1	0	0	0	0	0	0	0	1	11035	1335	47	4		4	OR2A5	7	143747689	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	90555	143747689	15390974	482	30810											
OR2A12	346525	broad.mit.edu	37	chr7	143793100	143793100	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagaggtgaaaggggctctAaagagagtcctttggaaaca	14	7	14	6	0	1	3	0	1	1	2	2	5	2	4	1	4	1	2	1	4	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143793100A>G	uc011kty.1	+	1	900	c.900A>G	c.(898-900)CTA>CTG	p.L300L		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					AAGGGGCTCTAAAGAGAGTCC	0.453													68	186					0	0	0	0	G	143793100	G	G	143793100	2	3	166	1	0	0	0	0	0	0	0	1	11029	349	13	5		5	OR2A12	7	143793100	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	45411	143793100	15345563	483	30811											
OR2A14	135941	broad.mit.edu	37	chr7	143826284	143826284	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcactggagattctcctcTgtggacttttctctgccttc	5	15	8	13	0	3	1	0	0	3	1	6	3	3	2	2	2	2	1	2	2	0	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143826284T>C	uc011kua.1	+	1	79	c.79T>C	c.(79-81)TGT>CGT	p.C27R		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GATTCTCCTCTGTGGACTTTT	0.502													28	80					0	0	0	0	C	143826284	C	C	143826284	3	2	166	1	0	0	0	0	1	0	0	0	11030	1580	55	5	81	5	OR2A14	7	143826284	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	33184	143826284	15312379	484	30812											
ZNF467	168544	broad.mit.edu	37	chr7	149462862	149462862	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgcactccgcgcacgggtaGggccgctcgcccgtgtgcgt	3	6	15	17	8	0	0	0	0	0	0	2	0	1	0	4	2	1	4	4	2	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:149462862G>A	uc003wgd.2	-	5	870	c.729C>T	c.(727-729)CCC>CCT	p.P243P	ZNF467_uc003wgc.2_Intron	NM_207336	NP_997219	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGCACGGGTAGGGCCGCTCGC	0.687													12	20					0	0	0	0	A	149462862	A	A	149462862	2	1	166	1	0	0	0	0	0	0	0	1	17994	987	35	4		4	ZNF467	7	149462862	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5636578	149462862	9675801	485	30813											
GALNTL5	168391	broad.mit.edu	37	chr7	151711783	151711783	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgctctcgagtaggacatAtcagtaagaaacaaactgga	15	8	9	9	1	2	1	1	0	1	1	3	4	2	3	1	2	3	3	1	2	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:151711783A>G	uc003wkp.2	+	8	1304	c.1081A>G	c.(1081-1083)ATC>GTC	p.I361V	GALNTL5_uc003wkq.2_Missense_Mutation_p.I112V|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.I250V	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	361	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		AGTAGGACATATCAGTAAGAA	0.408													22	57					0	0	0	0	G	151711783	G	G	151711783	3	3	166	1	0	0	0	0	1	0	0	0	6259	449	16	5	1107	5	GALNTL5	7	151711783	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2248921	151711783	7426880	486	30814											
PTPRN2	5799	broad.mit.edu	37	chr7	157364177	157364177	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacggcccctgtagcacttgTttacttttctgaaataaaaa	13	13	6	9	1	1	1	0	1	1	0	1	1	1	1	2	1	3	3	2	1	7	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:157364177T>C	uc003wno.2	-	20	2913	c.2792A>G	c.(2791-2793)AAC>AGC	p.N931S	PTPRN2_uc003wnp.2_Missense_Mutation_p.N914S|PTPRN2_uc003wnq.2_Missense_Mutation_p.N902S|PTPRN2_uc003wnr.2_Missense_Mutation_p.N893S|PTPRN2_uc011kwa.1_Missense_Mutation_p.N954S|PTPRN2_uc003wnn.2_5'Flank	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	931	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GTAGCACTTGTTTACTTTTCT	0.338													21	63					0	0	0	0	C	157364177	C	C	157364177	3	2	166	1	0	0	0	0	1	0	0	0	12873	1725	60	5	271	5	PTPRN2	7	157364177	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5652394	157364177	1774486	487	30815											
SGK223	157285	broad.mit.edu	37	chr8	8185684	8185684	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaggagaagacaggatggtGgcggttcccggggctcaacg	10	5	18	8	3	1	3	1	0	0	3	2	5	2	4	1	7	1	2	1	7	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:8185684G>A	uc003wsh.3	-	4	2608	c.2608C>T	c.(2608-2610)CAC>TAC	p.H870Y		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	870							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						ACAGGATGGTGGCGGTTCCCG	0.592													91	239					0	0	0	0	A	8185684	A	A	8185684	3	1	166	1	0	0	0	0	1	0	0	0	14275	1348	47	4	1608	4	SGK223	8	8185684	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08		8185684	138178338	488	30816											
MFHAS1	9258	broad.mit.edu	37	chr8	8750112	8750112	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgagcgagagcgcccagctGggcgggcagggcgggcagct	6	3	21	11	4	0	2	0	1	0	1	0	3	0	2	1	4	4	4	1	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:8750112G>C	uc003wsj.1	-	1	1020	c.457C>G	c.(457-459)CAG>GAG	p.Q153E		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	153	LRR 4.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GCGCCCAGCTGGGCGGGCAGG	0.692													6	13					0	0	0	0	C	8750112	C	C	8750112	3	2	166	1	0	0	0	0	1	0	0	0	9574	1357	47	4	2713	4	MFHAS1	8	8750112	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	564428	8750112	137613910	489	30817											
TNKS	8658	broad.mit.edu	37	chr8	9609323	9609323	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcctccaatgcaggggatGgcgccgcgggaacagaaagg	11	3	17	10	3	0	1	0	0	0	1	1	4	1	3	3	5	3	1	3	5	3	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:9609323G>T	uc003wss.2	+	19	3042	c.3037G>T	c.(3037-3039)GGC>TGC	p.G1013C	TNKS_uc011kww.1_Missense_Mutation_p.G776C|TNKS_uc010lrt.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1013					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		TGCAGGGGATGGCGCCGCGGG	0.522													39	101					5.44703e-19	1.26196e-18	1	0	T	9609323	T	T	9609323	3	4	166	1	0	0	0	0	1	0	0	0	16385	1348	47	4	3111	4	TNKS	8	9609323	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	859211	9609323	136754699	490	30818											
RP1L1	94137	broad.mit.edu	37	chr8	10470038	10470038	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctcctcactccgggcccTcggtgtcaggcggccgcctt	2	8	11	20	4	2	0	2	0	0	0	5	0	4	0	7	4	0	0	7	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:10470038T>A	uc003wtc.2	-	4	1799	c.1570A>T	c.(1570-1572)AGG>TGG	p.R524W		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	524					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTCCGGGCCCTCGGTGTCAGG	0.697													22	67					0	0	0	0	A	10470038	A	A	10470038	3	1	166	1	0	0	0	0	1	0	0	0	13598	1550	54	5	5636	5	RP1L1	8	10470038	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	860715	10470038	135893984	491	30819											
SGCZ	137868	broad.mit.edu	37	chr8	13959967	13959967	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcactcacctggaccccaCggggagcttccatgatcaag	10	6	10	15	1	2	1	2	1	0	0	3	3	3	3	4	3	2	2	4	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:13959967C>A	uc003wwq.2	-	7	1322	c.662G>T	c.(661-663)CGT>CTT	p.R221L	SGCZ_uc010lss.2_Missense_Mutation_p.R174L	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	208	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CTGGACCCCACGGGGAGCTTC	0.458													16	44					2.31682e-05	3.94524e-05	1	0	A	13959967	A	A	13959967	3	1	166	1	0	0	0	0	1	0	0	0	14269	536	19	3	284	3	SGCZ	8	13959967	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3489929	13959967	132404055	492	30820											
ATP6V1B2	526	broad.mit.edu	37	chr8	20075667	20075667	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctttcttctctttagtatGcgtgctatgctattggaaag	7	17	9	8	1	2	0	0	0	2	0	3	1	2	1	1	1	3	3	1	1	5	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:20075667G>A	uc003wzp.2	+	13	1484	c.1270G>A	c.(1270-1272)GCG>ACG	p.A424T	ATP6V1B2_uc003wzq.1_5'Flank	NM_001693	NP_001684	P21281	VATB2_HUMAN	vacuolar H+ATPase B2	424				AC -> RA (in Ref. 7; AAA35610).	ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		TCTTTAGTATGCGTGCTATGC	0.438													36	84					0	0	0	0	A	20075667	A	A	20075667	3	1	166	1	0	0	0	0	1	0	0	0	1181	1319	46	4	1320	4	ATP6V1B2	8	20075667	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	6115700	20075667	126288355	493	30821											
GFRA2	2675	broad.mit.edu	37	chr8	21560483	21560483	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgttgccaaaggcctggatgGcgttccctgggatgggggtg	5	9	18	9	2	0	0	0	0	0	0	1	2	1	2	3	6	1	2	3	6	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:21560483G>C	uc003wzu.1	-	7	1727	c.1052C>G	c.(1051-1053)GCC>GGC	p.A351G	GFRA2_uc003wzv.1_Missense_Mutation_p.A246G|GFRA2_uc003wzw.1_Missense_Mutation_p.A218G	NM_001495	NP_001486	O00451	GFRA2_HUMAN	GDNF family receptor alpha 2 isoform a	351						anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity				0				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		GGCCTGGATGGCGTTCCCTGG	0.632													5	11					0	0	0	0	C	21560483	C	C	21560483	3	2	166	1	0	0	0	0	1	0	0	0	6385	1203	42	4	354	4	GFRA2	8	21560483	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1484816	21560483	124803539	494	30822											
PEBP4	157310	broad.mit.edu	37	chr8	22675246	22675246	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaccaggatataggttgcGccctgtaacacatgtaccga	12	9	9	11	2	1	0	1	0	0	0	1	2	1	1	3	2	3	3	3	2	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:22675246G>T	uc003xcn.1	-	4	353	c.261C>A	c.(259-261)GGC>GGA	p.G87G		NM_144962	NP_659399	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	87						lysosome				ovary(1)|large_intestine(1)|breast(1)|skin(1)	4		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		TATAGGTTGCGCCCTGTAACA	0.493													29	56					5.45727e-16	1.20318e-15	1	0	T	22675246	T	T	22675246	2	4	166	1	0	0	0	0	0	0	0	1	11768	1074	38	3		3	PEBP4	8	22675246	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1114763	22675246	123688776	495	30823											
EBF2	64641	broad.mit.edu	37	chr8	25715905	25715905	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaacacccaagttggccatGgggacattgctgtagccatt	10	9	12	10	0	0	0	0	0	0	0	0	2	0	2	3	4	3	3	3	4	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:25715905G>T	uc003xes.1	-	14	1475	c.1458C>A	c.(1456-1458)CCC>CCA	p.P486P	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	486	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		AGTTGGCCATGGGGACATTGC	0.522													32	59					2.85442e-18	6.49786e-18	1	0	T	25715905	T	T	25715905	2	4	166	1	0	0	0	0	0	0	0	1	4903	1335	47	4		4	EBF2	8	25715905	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3040659	25715905	120648117	496	30824											
PTK2B	2185	broad.mit.edu	37	chr8	27295006	27295006	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcatggaattgtatccctAtggggaggtgagctggagga	10	10	15	6	0	1	1	1	1	0	0	2	5	2	5	1	6	1	2	1	6	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:27295006A>G	uc003xfn.1	+	22	2328	c.1520A>G	c.(1519-1521)TAT>TGT	p.Y507C	PTK2B_uc003xfo.1_Missense_Mutation_p.Y507C|PTK2B_uc003xfp.1_Missense_Mutation_p.Y507C|PTK2B_uc003xfq.1_Missense_Mutation_p.Y507C|PTK2B_uc003xfr.1_Missense_Mutation_p.Y253C	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	507	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TTGTATCCCTATGGGGAGGTG	0.552													12	29					0	0	0	0	G	27295006	G	G	27295006	3	3	166	1	0	0	0	0	1	0	0	0	12826	449	16	5	1582	5	PTK2B	8	27295006	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1579101	27295006	119069016	497	30825											
ESCO2	157570	broad.mit.edu	37	chr8	27641568	27641569	+	Frame_Shift_Ins	INS	-	A	A																															agtgcatcttcagtcaattcINSaaaaaggtgagaattgttat																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:27641568_27641569insA	uc003xgg.2	+	5	1090_1091	c.1007_1008insA	c.(1006-1008)TCAfs	p.S336fs	ESCO2_uc010luy.1_Intron	NM_001017420	NP_001017420	Q56NI9	ESCO2_HUMAN	establishment of cohesion 1 homolog 2	336					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			central_nervous_system(1)	1		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		TCAGTCAATTCAAAAAGGTGAG	0.351									SC_Phocomelia_syndrome				---	---	---								A	27641569	A	A	27641568	7	5	166	1	0	1	1	0	0	0	0	0	5273	838	29	0	1021	0	ESCO2	8	27641568	Frame_Shift_Ins	INS	-	TCGA-CR-7402-01A-11D-2012-08	346562	27641568	118722454	498	30826											
UNC5D	137970	broad.mit.edu	37	chr8	35406972	35406972	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatattcttcaaatgcaacgGcgagtgggtccatcagaacg	12	9	11	9	3	3	1	2	0	1	1	4	3	4	1	1	2	3	1	1	2	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:35406972G>T	uc003xjr.1	+	2	594	c.266G>T	c.(265-267)GGC>GTC	p.G89V	UNC5D_uc003xjs.1_Missense_Mutation_p.G84V	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	89	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AAATGCAACGGCGAGTGGGTC	0.507													17	29					5.01169e-05	8.45346e-05	1	0	T	35406972	T	T	35406972	3	4	166	1	0	0	0	0	1	0	0	0	17063	1203	42	4	272	4	UNC5D	8	35406972	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	7765404	35406972	110957050	499	30827											
EIF4EBP1	1978	broad.mit.edu	37	chr8	37914654	37914654	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgtcggaactcacctgtGaccaaaacacccccaaggga	13	5	10	13	1	1	1	1	1	0	0	2	4	1	3	4	2	2	0	4	2	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:37914654G>T	uc003xks.2	+	2	273	c.201G>T	c.(199-201)GTG>GTT	p.V67V		NM_004095	NP_004086	Q13541	4EBP1_HUMAN	eukaryotic translation initiation factor 4E	67					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|positive regulation of mitotic cell cycle|TOR signaling cascade|translation	cytosol					0	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)				ACTCACCTGTGACCAAAACAC	0.572													21	81					2.70639e-06	4.74466e-06	1	0	T	37914654	T	T	37914654	2	4	166	1	0	0	0	0	0	0	0	1	5056	1277	45	2		2	EIF4EBP1	8	37914654	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2507682	37914654	108449368	500	30828											
TM2D2	83877	broad.mit.edu	37	chr8	38853858	38853858	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcggtcgcattttgcgagTggctccgagacacacaatgc	9	8	12	12	4	0	1	0	0	0	1	2	3	1	1	1	2	3	2	1	2	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:38853858T>C	uc003xmk.2	-	1	184	c.101A>G	c.(100-102)CAC>CGC	p.H34R	ADAM9_uc011lcf.1_5'Flank|ADAM9_uc003xmr.2_5'Flank|ADAM9_uc011lcg.1_5'Flank|ADAM9_uc010lwr.2_5'Flank|TM2D2_uc003xml.2_5'UTR|TM2D2_uc003xmm.2_Intron|TM2D2_uc003xmn.2_Intron|ADAM9_uc003xmo.1_5'Flank|ADAM9_uc003xmp.2_5'Flank	NM_078473	NP_510882	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2 isoform a	34						integral to membrane					0		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			ATTTTGCGAGTGGCTCCGAGA	0.627													40	82					0	0	0	0	C	38853858	C	C	38853858	3	2	166	1	0	0	0	0	1	0	0	0	16030	1696	59	5	657	5	TM2D2	8	38853858	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	939204	38853858	107510164	501	30829											
PRKDC	5591	broad.mit.edu	37	chr8	48746771	48746771	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttacctttcactttgttaTccacctcgtcccctggaagg	6	14	7	14	1	1	0	1	0	0	0	4	1	3	1	5	2	1	2	5	2	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:48746771T>C	uc003xqi.2	-	60	8195	c.8138A>G	c.(8137-8139)GAT>GGT	p.D2713G	PRKDC_uc003xqj.2_Missense_Mutation_p.D2713G|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2713	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CACTTTGTTATCCACCTCGTC	0.488								NHEJ					115	238					0	0	0	0	C	48746771	C	C	48746771	3	2	166	1	0	0	0	0	1	0	0	0	12583	1435	50	5	4360	5	PRKDC	8	48746771	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	9892913	48746771	97617251	502	30830											
PXDNL	137902	broad.mit.edu	37	chr8	52384809	52384809	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccggcaggtgaagtagacGgtatttcctgatggtacctc	8	10	13	10	2	0	3	0	2	0	1	2	3	1	3	3	4	1	4	3	4	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:52384809G>T	uc003xqu.3	-	8	851	c.750C>A	c.(748-750)ACC>ACA	p.T250T		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	250	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGAAGTAGACGGTATTTCCTG	0.428													35	93					1.67305e-13	3.4627e-13	1	0	T	52384809	T	T	52384809	2	4	166	1	0	0	0	0	0	0	0	1	12913	1103	39	3		3	PXDNL	8	52384809	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3638038	52384809	93979213	503	30831											
RP1	6101	broad.mit.edu	37	chr8	55537480	55537480	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaataaaagaggaagaaacCataaaatggacaactactgt	22	6	8	5	0	0	3	0	0	0	3	0	5	0	5	1	2	3	0	1	2	9	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:55537480C>T	uc003xsd.1	+	4	1186	c.1038C>T	c.(1036-1038)ACC>ACT	p.T346T	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	346					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AGGAAGAAACCATAAAATGGA	0.343													9	20					0	0	0	0	T	55537480	T	T	55537480	2	4	166	1	0	0	0	0	0	0	0	1	13597	581	21	4		4	RP1	8	55537480	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3152671	55537480	90826542	504	30832											
XKR4	114786	broad.mit.edu	37	chr8	56436507	56436507	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaccgcagtgttgtcagcgaCcgcgatcagaaattcgcaga	12	7	11	11	5	2	2	2	0	0	2	3	4	2	2	2	0	2	3	2	0	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:56436507C>A	uc003xsf.2	+	3	1706	c.1674C>A	c.(1672-1674)GAC>GAA	p.D558E		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	558						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TTGTCAGCGACCGCGATCAGA	0.592													19	56					5.35267e-07	9.60735e-07	1	0	A	56436507	A	A	56436507	3	1	166	1	0	0	0	0	1	0	0	0	17501	506	18	4	1684	4	XKR4	8	56436507	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	899027	56436507	89927515	505	30833											
ASPH	444	broad.mit.edu	37	chr8	62566183	62566183	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggctcagcctcttctggcGggactgctggctctgaagta	5	11	14	11	1	4	1	1	1	3	0	4	2	4	2	1	4	2	4	1	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:62566183G>A	uc003xuj.2	-	4	628	c.359C>T	c.(358-360)CCG>CTG	p.P120L	ASPH_uc011leg.1_Missense_Mutation_p.P91L|ASPH_uc003xuo.2_Missense_Mutation_p.P120L|ASPH_uc011leh.1_Missense_Mutation_p.P106L|ASPH_uc003xul.2_Missense_Mutation_p.P106L|ASPH_uc011lei.1_Missense_Mutation_p.P106L|ASPH_uc011lej.1_Missense_Mutation_p.P106L|ASPH_uc003xun.2_Missense_Mutation_p.P120L|ASPH_uc011lek.1_Missense_Mutation_p.P120L|ASPH_uc003xum.2_Missense_Mutation_p.P120L	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	120	Glu-rich.|Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	CTCTTCTGGCGGGACTGCTGG	0.502													7	30					0	0	0	0	A	62566183	A	A	62566183	3	1	166	1	0	0	0	0	1	0	0	0	1055	1116	39	1	2017	1	ASPH	8	62566183	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	6129676	62566183	83797839	506	30834											
MTFR1	9650	broad.mit.edu	37	chr8	66605983	66605983	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaagaaggagagtgttcAgcaagactaaggttagtttg	16	9	13	3	0	1	4	1	0	0	4	1	5	1	4	0	2	1	4	0	2	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:66605983A>T	uc003xvm.2	+	4	482	c.270A>T	c.(268-270)TCA>TCT	p.S90S	MTFR1_uc011lep.1_Silent_p.S90S|MTFR1_uc003xvn.2_Silent_p.S57S|MTFR1_uc003xvo.1_Silent_p.S80S	NM_014637	NP_055452	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1 isoform 1	90						mitochondrion|plasma membrane				pancreas(1)	1			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			GAGAGTGTTCAGCAAGACTAA	0.408													16	25					0	0	0	0	T	66605983	T	T	66605983	2	4	166	1	0	0	0	0	0	0	0	1	9978	175	7	5		5	MTFR1	8	66605983	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	4039800	66605983	79758039	507	30835											
PREX2	80243	broad.mit.edu	37	chr8	69002942	69002942	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgcaggaagtacaggcggCcaacgaaggtaagtggccct	11	5	14	11	2	0	0	0	0	0	0	0	2	0	1	3	5	3	3	3	5	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:69002942C>A	uc003xxv.1	+	20	2269	c.2242C>A	c.(2242-2244)CCA>ACA	p.P748T	PREX2_uc003xxu.1_Missense_Mutation_p.P748T|PREX2_uc011lez.1_Missense_Mutation_p.P683T	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	748	PDZ 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GTACAGGCGGCCAACGAAGGT	0.483													11	45					3.86212e-05	6.52565e-05	1	0	A	69002942	A	A	69002942	3	1	166	1	0	0	0	0	1	0	0	0	12539	739	26	4	2320	4	PREX2	8	69002942	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2396959	69002942	77361080	508	30836											
SULF1	23213	broad.mit.edu	37	chr8	70476335	70476335	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcaggaacgaaaaaacatccGacccaacattattcttgtgc	15	8	7	11	2	1	0	0	0	1	0	2	3	2	1	2	1	4	1	2	1	6	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:70476335G>C	uc010lza.1	+	5	842	c.125G>C	c.(124-126)CGA>CCA	p.R42P	SULF1_uc003xyd.2_Missense_Mutation_p.R42P|SULF1_uc003xye.2_Missense_Mutation_p.R42P|SULF1_uc003xyf.2_Missense_Mutation_p.R42P|SULF1_uc003xyg.2_Missense_Mutation_p.R42P	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	42					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AAAAACATCCGACCCAACATT	0.483													28	70					0	0	0	0	C	70476335	C	C	70476335	3	2	166	1	0	0	0	0	1	0	0	0	15436	1058	37	3	127	3	SULF1	8	70476335	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1473393	70476335	75887687	509	30837											
CRISPLD1	83690	broad.mit.edu	37	chr8	75929588	75929588	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagagctgcaattcattatGgtataatagacaatgatggt	14	13	10	4	0	1	3	1	1	0	2	1	3	1	3	0	2	2	4	0	2	7	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:75929588G>C	uc003yan.2	+	10	1405	c.1030G>C	c.(1030-1032)GGT>CGT	p.G344R	CRISPLD1_uc011lfk.1_Missense_Mutation_p.G156R|CRISPLD1_uc011lfl.1_Missense_Mutation_p.G156R	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	344	LCCL 1.					extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			AATTCATTATGGTATAATAGA	0.343													44	62					0	0	0	0	C	75929588	C	C	75929588	3	2	166	1	0	0	0	0	1	0	0	0	3897	1348	47	4	1064	4	CRISPLD1	8	75929588	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5453253	75929588	70434434	510	30838											
ZFHX4	79776	broad.mit.edu	37	chr8	77765155	77765155	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atccaatttctccatcttctCcagaaacgccgcccccgcca	9	9	4	19	3	3	1	0	0	3	1	6	1	4	1	7	0	1	0	7	0	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:77765155C>A	uc003yav.2	+	10	6250	c.5863C>A	c.(5863-5865)CCA>ACA	p.P1955T	ZFHX4_uc003yau.1_Missense_Mutation_p.P2000T|ZFHX4_uc003yaw.1_Missense_Mutation_p.P1955T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1955	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCCATCTTCTCCAGAAACGcc	0.308										HNSCC(33;0.089)			8	18					0.000157383	0.00026186	1	0	A	77765155	A	A	77765155	3	1	166	1	0	0	0	0	1	0	0	0	17702	855	30	2	6032	2	ZFHX4	8	77765155	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1835567	77765155	68598867	511	30839											
ZFHX4	79776	broad.mit.edu	37	chr8	77775784	77775784	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcttattttacacctcagctCcctggaacagtgcagggggg	8	11	11	11	0	2	0	1	0	1	0	3	1	3	1	2	4	4	2	2	4	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:77775784C>A	uc003yav.2	+	11	10086	c.9699C>A	c.(9697-9699)CTC>CTA	p.L3233L		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3229						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CACCTCAGCTCCCTGGAACAG	0.517										HNSCC(33;0.089)			35	100					2.20474e-14	4.69195e-14	1	0	A	77775784	A	A	77775784	2	1	166	1	0	0	0	0	0	0	0	1	17702	842	30	2		2	ZFHX4	8	77775784	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	10629	77775784	68588238	512	30840											
ZNF704	619279	broad.mit.edu	37	chr8	81605276	81605276	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggacttcgaaccaaagggctAgtcgacaagctggttagtac	12	8	12	9	2	0	0	0	0	0	0	2	3	0	1	1	3	3	4	1	3	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:81605276A>C	uc003yby.1	-	3	520	c.288T>G	c.(286-288)ACT>ACG	p.T96T		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	96						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			CCAAAGGGCTAGTCGACAAGC	0.512													15	41					0	0	0	0	C	81605276	C	C	81605276	2	2	166	1	0	0	0	0	0	0	0	1	18174	407	15	5		5	ZNF704	8	81605276	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	3829492	81605276	64758746	513	30841											
ATP6V0D2	245972	broad.mit.edu	37	chr8	87165148	87165148	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagaaatattgtgtggatagCagaatgtatttcacagaggc	14	12	11	4	0	1	3	1	0	0	3	1	4	1	4	0	2	1	2	0	2	6	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:87165148C>A	uc003ydp.1	+	8	1064	c.995C>A	c.(994-996)GCA>GAA	p.A332E		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	332					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0						GTGTGGATAGCAGAATGTATT	0.333													15	40					1.49906e-05	2.56832e-05	1	0	A	87165148	A	A	87165148	3	1	166	1	0	0	0	0	1	0	0	0	1176	710	25	4	1025	4	ATP6V0D2	8	87165148	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5559872	87165148	59198874	514	30842											
DCAF4L2	138009	broad.mit.edu	37	chr8	88885723	88885723	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctatgaacagcgacgctggGagcagcacggcacagcttgg	10	5	14	12	3	0	1	0	1	0	0	0	3	0	2	1	3	5	5	1	3	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:88885723G>T	uc003ydz.2	-	1	574	c.477C>A	c.(475-477)CTC>CTA	p.L159L		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	159										ovary(1)	1						GCGACGCTGGGAGCAGCACGG	0.562													26	61					1.37878e-21	3.27565e-21	1	0	T	88885723	T	T	88885723	2	4	166	1	0	0	0	0	0	0	0	1	4289	1161	41	2		2	DCAF4L2	8	88885723	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1720575	88885723	57478299	515	30843											
NECAB1	64168	broad.mit.edu	37	chr8	91929810	91929810	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtctctccagaattccCtggaatgtgccatggaaact	10	11	9	11	0	1	1	0	0	1	1	4	3	3	3	3	2	3	1	3	2	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:91929810C>A	uc011lgg.1	+	6	642	c.448C>A	c.(448-450)CTG>ATG	p.L150M		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	150	Potential.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			CCAGAATTCCCTGGAATGTGC	0.403													19	33					0.00152264	0.00248905	1	0	A	91929810	A	A	91929810	3	1	166	1	0	0	0	0	1	0	0	0	10358	680	24	4	470	4	NECAB1	8	91929810	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3044087	91929810	54434212	516	30844											
CDH17	1015	broad.mit.edu	37	chr8	95161033	95161033	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttctctgtccaatggagcCacactaaagatctcaccagt	11	10	7	13	0	2	1	1	0	2	1	5	2	3	2	3	1	1	1	3	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:95161033C>T	uc003ygh.2	-	14	1991	c.1866G>A	c.(1864-1866)GTG>GTA	p.V622V	CDH17_uc011lgo.1_Silent_p.V408V|CDH17_uc011lgp.1_Silent_p.V622V	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	622	Cadherin 6.|Extracellular (Potential).					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CCAATGGAGCCACACTAAAGA	0.413													8	19					0	0	0	0	T	95161033	T	T	95161033	2	4	166	1	0	0	0	0	0	0	0	1	3117	581	21	4		4	CDH17	8	95161033	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3231223	95161033	51202989	517	30845											
KIAA1429	25962	broad.mit.edu	37	chr8	95543280	95543280	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggctgtggtcttggagggCttccattaaactgatcttct	6	16	11	8	0	3	1	0	1	3	0	4	2	4	2	1	4	1	2	1	4	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:95543280C>A	uc003ygo.1	-	6	531	c.518G>T	c.(517-519)AGC>ATC	p.S173I	KIAA1429_uc003ygp.2_Missense_Mutation_p.S173I	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	173	Pro-rich.				mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCTTGGAGGGCTTCCATTAAA	0.393													11	46					1.08611e-07	1.97841e-07	1	0	A	95543280	A	A	95543280	3	1	166	1	0	0	0	0	1	0	0	0	8270	797	28	4	5050	4	KIAA1429	8	95543280	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	382247	95543280	50820742	518	30846											
MTDH	92140	broad.mit.edu	37	chr8	98731417	98731417	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtactcgtcaaaaatagccaGgtaatttttaagaataataa	18	12	6	5	1	1	1	1	0	0	1	2	1	1	1	1	1	2	2	1	1	9	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:98731417G>T	uc003yhz.2	+	10	1849	c.1521G>T	c.(1519-1521)CAG>CAT	p.Q507H	MTDH_uc010mbf.2_RNA	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	507	Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			AAAATAGCCAGGTAATTTTTA	0.229													24	54					1.5548e-18	3.5559e-18	1	0	T	98731417	T	T	98731417	3	4	166	1	0	0	0	0	1	0	0	0	9970	1014	35	4	1559	4	MTDH	8	98731417	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3188137	98731417	47632605	519	30847											
GRHL2	79977	broad.mit.edu	37	chr8	102656368	102656369	+	Missense_Mutation	DNP	CC	GT	GT																															atcttttctagtggcagtgtCcttgttaaacggatgttccg																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:102656368_102656369CC>GT	uc010mbu.2	+	13	1857_1858	c.1527_1528CC>GT	c.(1525-1530)GTCCTT>GTGTTT	p.L510F		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	510						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			GTGGCAGTGTCCTTGTTAAACG	0.465													8	25					0	0	0	0	GT	102656369	GT	GT	102656368	3	3	166	1	0	0	0	0	1	0	0	0	6803	842	30	2	1577	2	GRHL2	8	102656368	Missense_Mutation	DNP	CC	TCGA-CR-7402-01A-11D-2012-08	3924951	102656368	43707654	520	30848											
ATP6V1C1	528	broad.mit.edu	37	chr8	104068161	104068161	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatggtagttccaaggtctaGcaagtaagtagaagtctttg	13	12	11	5	0	2	1	0	0	2	1	3	1	3	1	1	2	1	5	1	2	8	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:104068161G>A	uc003ykz.3	+	8	883	c.638G>A	c.(637-639)AGC>AAC	p.S213N	ATP6V1C1_uc010mbz.2_Missense_Mutation_p.S138N|ATP6V1C1_uc003yla.2_Missense_Mutation_p.S213N|ATP6V1C1_uc011lhl.1_Missense_Mutation_p.S138N	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	213					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			CCAAGGTCTAGCAAGTAAGTA	0.373													9	30					0	0	0	0	A	104068161	A	A	104068161	3	1	166	1	0	0	0	0	1	0	0	0	1182	971	34	4	664	4	ATP6V1C1	8	104068161	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1411793	104068161	42295861	521	30849											
RIMS2	9699	broad.mit.edu	37	chr8	104898151	104898151	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccccaggaggagtccactaCccatagatagaccagacttg	12	6	9	14	0	0	3	0	0	0	3	1	5	1	5	5	2	1	0	5	2	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:104898151C>G	uc003yls.2	+	2	899	c.658C>G	c.(658-660)CCC>GCC	p.P220A	RIMS2_uc003ylp.2_Missense_Mutation_p.P442A|RIMS2_uc003ylw.2_Missense_Mutation_p.P250A|RIMS2_uc003ylq.2_Missense_Mutation_p.P250A|RIMS2_uc003ylr.2_Missense_Mutation_p.P250A	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	473					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAGTCCACTACCCATAGATAG	0.463										HNSCC(12;0.0054)			10	44					0	0	0	0	G	104898151	G	G	104898151	3	3	166	1	0	0	0	0	1	0	0	0	13433	507	18	4	1464	4	RIMS2	8	104898151	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	829990	104898151	41465871	522	30850											
RIMS2	9699	broad.mit.edu	37	chr8	105027684	105027684	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggagatagaaccttatgaaGgtctgtacataaaagagggt	16	9	12	4	0	1	4	0	1	1	3	1	5	1	4	1	3	2	1	1	3	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:105027684G>A	uc003yls.2	+	18	2828	c.2587G>A	c.(2587-2589)GAA>AAA	p.E863K	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.E937K|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACCTTATGAAGGTCTGTACAT	0.323										HNSCC(12;0.0054)			4	5					0	0	0	0	A	105027684	A	A	105027684	3	1	166	1	0	0	0	0	1	0	0	0	13433	1015	35	4		4	RIMS2	8	105027684	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	129533	105027684	41336338	523	30851											
KCNV1	27012	broad.mit.edu	37	chr8	110980754	110980754	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agttgaaaatatagagattcCcacggatagaaataggagca	18	8	10	5	1	0	3	0	1	0	2	1	6	1	5	1	2	1	2	1	2	7	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:110980754C>A	uc003ynr.3	-	3	1408	c.1066G>T	c.(1066-1068)GGA>TGA	p.G356*	KCNV1_uc010mcw.2_Nonsense_Mutation_p.G356*	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	356	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			ATAGAGATTCCCACGGATAGA	0.478													35	53					2.80507e-11	5.57036e-11	1	0	A	110980754	A	A	110980754	4	1	166	1	0	0	0	0	0	1	0	0	8133	632	22	4	440	4	KCNV1	8	110980754	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5953070	110980754	35383268	524	30852											
CSMD3	114788	broad.mit.edu	37	chr8	113246700	113246700	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcgagcttcctggcttttaTatacccctgtaaaatgcaag	10	12	9	10	1	0	0	0	0	0	0	1	1	1	0	3	2	3	4	3	2	6	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:113246700T>C	uc003ynu.2	-	68	10793	c.10634A>G	c.(10633-10635)TAT>TGT	p.Y3545C	CSMD3_uc003yns.2_Missense_Mutation_p.Y2747C|CSMD3_uc003ynt.2_Missense_Mutation_p.Y3505C|CSMD3_uc011lhx.1_Missense_Mutation_p.Y3376C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3545	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTGGCTTTTATATACCCCTGT	0.313										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			36	82					0	0	0	0	C	113246700	C	C	113246700	3	2	166	1	0	0	0	0	1	0	0	0	3963	1406	49	5	505	5	CSMD3	8	113246700	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2265946	113246700	33117322	525	30853											
CSMD3	114788	broad.mit.edu	37	chr8	113256746	113256746	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtatacccatgagatggaaGgtccatccctacgacatttg	11	11	9	10	1	0	1	0	1	0	1	2	4	2	2	3	2	2	1	3	2	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:113256746G>T	uc003ynu.2	-	65	10438	c.10279C>A	c.(10279-10281)CTT>ATT	p.L3427I	CSMD3_uc003yns.2_Missense_Mutation_p.L2629I|CSMD3_uc003ynt.2_Missense_Mutation_p.L3387I|CSMD3_uc011lhx.1_Missense_Mutation_p.L3258I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3427	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGAGATGGAAGGTCCATCCCT	0.418										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	50					0.000308642	0.000509636	1	0	T	113256746	T	T	113256746	3	4	166	1	0	0	0	0	1	0	0	0	3963	1000	35	4	872	4	CSMD3	8	113256746	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	10046	113256746	33107276	526	30854											
CSMD3	114788	broad.mit.edu	37	chr8	113418923	113418923	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgaatcttggttcaggcacaGaactgcattgtgtagaactt	11	12	10	8	1	2	2	1	0	1	2	2	3	2	2	0	2	3	4	0	2	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:113418923G>A	uc003ynu.2	-	35	5798	c.5639C>T	c.(5638-5640)TCT>TTT	p.S1880F	CSMD3_uc003yns.2_Missense_Mutation_p.S1082F|CSMD3_uc003ynt.2_Missense_Mutation_p.S1840F|CSMD3_uc011lhx.1_Missense_Mutation_p.S1776F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1880	Sushi 10.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTCAGGCACAGAACTGCATTG	0.338										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	48					0	0	0	0	A	113418923	A	A	113418923	3	1	166	1	0	0	0	0	1	0	0	0	3963	942	33	2	5632	2	CSMD3	8	113418923	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	162177	113418923	32945099	527	30855											
ADCY8	114	broad.mit.edu	37	chr8	131861992	131861992	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcctctgctgtggtgatgagGaccagagccgagtgcagcat	8	9	14	10	1	1	3	0	2	1	1	2	5	2	4	3	2	4	3	3	2	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:131861992G>C	uc003ytd.3	-	10	2524	c.2268C>G	c.(2266-2268)GTC>GTG	p.V756V	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	756	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TGGTGATGAGGACCAGAGCCG	0.473										HNSCC(32;0.087)			3	11					0	0	0	0	C	131861992	C	C	131861992	2	2	166	1	0	0	0	0	0	0	0	1	300	1161	41	2		2	ADCY8	8	131861992	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	18443069	131861992	14502030	528	30856											
PHF20L1	51105	broad.mit.edu	37	chr8	133816972	133816972	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggcaaagagagctcgactTaacaagattactggtaaact	16	8	9	8	1	0	2	0	0	0	2	1	4	0	2	0	2	4	3	0	2	6	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:133816972T>G	uc003ytt.2	+	8	1159	c.834T>G	c.(832-834)CTT>CTG	p.L278L	PHF20L1_uc003ytr.2_Silent_p.L252L|PHF20L1_uc010mdv.2_Silent_p.L252L|PHF20L1_uc003yts.2_Silent_p.L278L|PHF20L1_uc011lja.1_Silent_p.L252L|PHF20L1_uc003ytu.1_RNA|PHF20L1_uc003ytv.2_Silent_p.L117L	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	278							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GAGCTCGACTTAACAAGATTA	0.343													20	52					0	0	0	0	G	133816972	G	G	133816972	2	3	166	1	0	0	0	0	0	0	0	1	11887	1741	61	5		5	PHF20L1	8	133816972	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1954980	133816972	12547050	529	30857											
TG	7038	broad.mit.edu	37	chr8	133899673	133899673	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctccaccttgtttgtccctGcttgtactagtgagggacat	6	14	10	11	0	0	1	0	1	0	0	2	2	2	2	3	1	2	4	3	1	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:133899673G>T	uc003ytw.2	+	9	2097	c.2056G>T	c.(2056-2058)GCT>TCT	p.A686S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	686	Thyroglobulin type-1 6.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTTTGTCCCTGCTTGTACTAG	0.557													21	46					1.01871e-10	1.99867e-10	1	0	T	133899673	T	T	133899673	3	4	166	1	0	0	0	0	1	0	0	0	15879	1319	46	4	2090	4	TG	8	133899673	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	82701	133899673	12464349	530	30858											
SLA	6503	broad.mit.edu	37	chr8	134050883	134050883	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtgttgtcctcactggtCagggacaggtaagaggcaat	10	9	15	7	0	2	1	2	0	0	1	3	3	3	2	1	5	0	3	1	5	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:134050883C>A	uc003ytz.2	-	9	1549	c.717G>T	c.(715-717)CTG>CTT	p.L239L	TG_uc003ytw.2_Intron|TG_uc010mdw.2_Intron|TG_uc011ljb.1_Intron|TG_uc011ljc.1_Intron|SLA_uc011lje.1_Silent_p.L256L|SLA_uc011ljf.1_Silent_p.L131L|SLA_uc011ljg.1_Silent_p.L212L|SLA_uc011ljd.1_Silent_p.L279L	NM_001045556	NP_001039021	Q13239	SLAP1_HUMAN	Src-like-adaptor isoform a	239	SLA C-terminal.			LSL->QSQ: Abolishes interaction with CBL. Slightly affects dimerization.		endosome	SH3/SH2 adaptor activity			lung(1)|liver(1)	2	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			CCTCACTGGTCAGGGACAGGT	0.522													37	75					8.73648e-17	1.94144e-16	1	0	A	134050883	A	A	134050883	2	1	166	1	0	0	0	0	0	0	0	1	14428	813	29	2		2	SLA	8	134050883	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	151210	134050883	12313139	531	30859											
CPSF1	29894	broad.mit.edu	37	chr8	145626066	145626066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctccttagggggctcaccCaggccaggtctggttgggct	4	9	15	13	0	2	0	1	0	1	0	3	0	3	0	4	6	0	3	4	6	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:145626066C>T	uc003zcj.2	-	7	760	c.685G>A	c.(685-687)GGG>AGG	p.G229R	CPSF1_uc003zck.1_Missense_Mutation_p.G151R|CPSF1_uc011lle.1_Missense_Mutation_p.G229R|MIR1234_hsa-mir-1234|MI0006324_5'Flank|CPSF1_uc011llf.1_Missense_Mutation_p.G229R	NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	229					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GGGGCTCACCCAGGCCAGGTC	0.637													8	19					0	0	0	0	T	145626066	T	T	145626066	3	4	166	1	0	0	0	0	1	0	0	0	3839	608	21	4	3774	4	CPSF1	8	145626066	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	11575183	145626066	737956	532	30860											
KIAA1432	57589	broad.mit.edu	37	chr9	5757415	5757415	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcactctgacatcagtgagTacagagaatggaatcacctt	13	10	9	9	0	4	3	3	2	1	1	4	5	4	4	1	1	1	1	1	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:5757415T>C	uc003zji.2	+	16	1812	c.1719T>C	c.(1717-1719)AGT>AGC	p.S573S	KIAA1432_uc003zjh.2_Silent_p.S573S|KIAA1432_uc003zjl.3_Silent_p.S536S|KIAA1432_uc003zjj.1_Silent_p.S115S	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	652						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CATCAGTGAGTACAGAGAATG	0.413													36	102					0	0	0	0	C	5757415	C	C	5757415	2	2	166	1	0	0	0	0	0	0	0	1	8272	1635	57	5		5	KIAA1432	9	5757415	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08		5757415	135456016	533	30861											
KDM4C	23081	broad.mit.edu	37	chr9	6984211	6984211	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaaggcctaaggctgatgaGgaagaggaagtgtcagatga	16	6	15	4	0	1	5	1	3	0	2	1	7	1	7	1	4	0	1	1	4	5	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:6984211G>T	uc003zkh.2	+	10	1741	c.1161G>T	c.(1159-1161)GAG>GAT	p.E387D	KDM4C_uc010mhu.2_Missense_Mutation_p.E409D|KDM4C_uc011lmi.1_Missense_Mutation_p.E387D|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.E387D|KDM4C_uc011lmk.1_Missense_Mutation_p.E206D|KDM4C_uc011lml.1_Missense_Mutation_p.E74D	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	387					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						AGGCTGATGAGGAAGAGGAAG	0.498													21	51					2.37509e-13	4.88989e-13	1	0	T	6984211	T	T	6984211	3	4	166	1	0	0	0	0	1	0	0	0	8169	991	35	4	1265	4	KDM4C	9	6984211	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1226796	6984211	134229220	534	30862											
PTPRD	5789	broad.mit.edu	37	chr9	8460478	8460478	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgcaaggacaggacctacaaCccagatcaagccttcttctt	12	9	7	13	0	3	1	1	0	2	1	3	3	3	3	3	2	4	1	3	2	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:8460478C>G	uc003zkk.2	-	32	4519	c.3808G>C	c.(3808-3810)GTT>CTT	p.V1270L	PTPRD_uc003zkp.2_Missense_Mutation_p.V859L|PTPRD_uc003zkq.2_Missense_Mutation_p.V859L|PTPRD_uc003zkr.2_Missense_Mutation_p.V854L|PTPRD_uc003zks.2_Missense_Mutation_p.V849L|PTPRD_uc003zkl.2_Missense_Mutation_p.V1261L|PTPRD_uc003zkm.2_Missense_Mutation_p.V1257L|PTPRD_uc003zkn.2_Missense_Mutation_p.V859L|PTPRD_uc003zko.2_Missense_Mutation_p.V856L	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1270	Helical; (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGACCTACAACCCAGATCAAG	0.448										TSP Lung(15;0.13)			19	51					0	0	0	0	G	8460478	G	G	8460478	3	3	166	1	0	0	0	0	1	0	0	0	12864	507	18	4	2051	4	PTPRD	9	8460478	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1476267	8460478	132752953	535	30863											
BNC2	54796	broad.mit.edu	37	chr9	16437135	16437135	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agttgaaaggctgggttcccGcagcctcaaccctggttgct	7	10	12	12	1	1	1	1	1	0	0	2	1	2	1	3	3	3	6	3	3	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:16437135G>A	uc003zml.2	-	6	1197	c.1057C>T	c.(1057-1059)CGG>TGG	p.R353W	BNC2_uc011lmw.1_Missense_Mutation_p.R258W|BNC2_uc003zmm.2_Missense_Mutation_p.R311W|BNC2_uc003zmq.1_Missense_Mutation_p.R367W|BNC2_uc003zmr.1_Missense_Mutation_p.R390W|BNC2_uc003zmp.1_Missense_Mutation_p.R381W|BNC2_uc010mij.1_Missense_Mutation_p.R275W|BNC2_uc011lmv.1_Missense_Mutation_p.R179W|BNC2_uc003zmo.1_Missense_Mutation_p.R275W|BNC2_uc003zmj.2_Missense_Mutation_p.R118W|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.R118W|BNC2_uc003zmn.1_Missense_Mutation_p.R118W	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		CTGGGTTCCCGCAGCCTCAAC	0.468													30	101					0	0	0	0	A	16437135	A	A	16437135	3	1	166	1	0	0	0	0	1	0	0	0	1478	1086	38	1	2250	1	BNC2	9	16437135	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	7976657	16437135	124776296	536	30864											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18889647	18889647	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcagccccgcttgaggtGcctgctgaacagcacggagg	8	6	14	13	2	1	2	1	2	0	0	1	3	1	3	3	3	6	4	3	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:18889647G>A	uc003zne.3	+	25	4671	c.4544G>A	c.(4543-4545)TGC>TAC	p.C1515Y	ADAMTSL1_uc003znf.3_Missense_Mutation_p.C216Y	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1515						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CGCTTGAGGTGCCTGCTGAAC	0.642													8	20					0	0	0	0	A	18889647	A	A	18889647	3	1	166	1	0	0	0	0	1	0	0	0	274	1319	46	4	4646	4	ADAMTSL1	9	18889647	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2452512	18889647	122323784	537	30865											
PLAA	9373	broad.mit.edu	37	chr9	26905641	26905641	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcatttgaatcatcactgatAagtgttccaagagccacaag	14	10	8	9	0	2	3	2	2	0	1	3	3	3	3	2	0	1	2	2	0	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:26905641A>G	uc003zqd.2	-	14	2681	c.2256T>C	c.(2254-2256)CTT>CTC	p.L752L		NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	752	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		CATCACTGATAAGTGTTCCAA	0.373													18	53					0	0	0	0	G	26905641	G	G	26905641	2	3	166	1	0	0	0	0	0	0	0	1	12066	349	13	5		5	PLAA	9	26905641	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	8015994	26905641	114307790	538	30866											
PRSS3	5646	broad.mit.edu	37	chr9	33799064	33799064	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtggtctgcaacggacagctCcaaggagttgtctcctgggg	7	9	15	10	1	2	0	0	0	2	0	4	2	3	2	2	5	3	3	2	5	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:33799064C>G	uc003ztj.3	+	5	801	c.801C>G	c.(799-801)CTC>CTG	p.L267L	uc003ztk.1_Intron|PRSS3_uc003zti.3_Silent_p.L224L|PRSS3_uc003ztl.3_Silent_p.L210L	NM_007343	NP_031369	P35030	TRY3_HUMAN	mesotrypsin isoform 1 preproprotein	267	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity				0			LUSC - Lung squamous cell carcinoma(29;0.0176)			ACGGACAGCTCCAAGGAGTTG	0.522													34	100					0	0	0	0	G	33799064	G	G	33799064	2	3	166	1	0	0	0	0	0	0	0	1	12684	842	30	2		2	PRSS3	9	33799064	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	6893423	33799064	107414367	539	30867											
C9orf131	138724	broad.mit.edu	37	chr9	35044685	35044686	+	Frame_Shift_Ins	INS	-	C	C																															ctgggccactgagctcccagINScccccagctcactctctact																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35044685_35044686insC	uc003zvw.2	+	2	2088_2089	c.2059_2060insC	c.(2059-2061)GCCfs	p.A687fs	C9orf131_uc003zvu.2_Frame_Shift_Ins_p.A639fs|C9orf131_uc003zvv.2_Frame_Shift_Ins_p.A614fs|C9orf131_uc003zvx.2_Frame_Shift_Ins_p.A652fs	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	687											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TGAGCTCCCAGCCCCCAGCTCA	0.54													---	---	---								C	35044686	C	C	35044685	7	5	166	1	0	1	1	0	0	0	0	0	2469	971	34	0	2081	0	C9orf131	9	35044685	Frame_Shift_Ins	INS	-	TCGA-CR-7402-01A-11D-2012-08	1245621	35044685	106168746	540	30868											
VCP	7415	broad.mit.edu	37	chr9	35061050	35061050	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aactgctagagagttcatgaCctcggcatcaatggtctcat	11	11	9	10	1	3	2	3	1	1	1	5	3	3	2	1	2	2	3	1	2	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35061050C>A	uc003zvy.2	-	11	1710	c.1321G>T	c.(1321-1323)GTC>TTC	p.V441F	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.V110F|VCP_uc010mki.1_Missense_Mutation_p.V396F	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	441					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GAGTTCATGACCTCGGCATCA	0.527													54	181					1.54886e-18	3.55476e-18	1	0	A	35061050	A	A	35061050	3	1	166	1	0	0	0	0	1	0	0	0	17208	507	18	4	1127	4	VCP	9	35061050	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	16365	35061050	106152381	541	30869											
RUSC2	9853	broad.mit.edu	37	chr9	35557972	35557972	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctcattttggcacaagccgGgatcccggggtgaaggtagg	8	8	16	9	2	1	1	1	1	0	0	2	2	2	2	2	6	1	3	2	6	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35557972G>T	uc003zww.2	+	6	3300	c.3045G>T	c.(3043-3045)CGG>CGT	p.R1015R	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Silent_p.R1015R	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1015						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GCACAAGCCGGGATCCCGGGG	0.557													24	73					3.80469e-20	8.8882e-20	1	0	T	35557972	T	T	35557972	2	4	166	1	0	0	0	0	0	0	0	1	13816	1219	43	4		4	RUSC2	9	35557972	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	496922	35557972	105655459	542	30870											
TESK1	7016	broad.mit.edu	37	chr9	35609311	35609311	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacctccagggccagcgcccCagctgcctctggctgtggcc	5	6	12	18	1	1	0	0	0	1	0	2	0	2	0	7	3	4	2	7	3	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35609311C>T	uc003zxa.2	+	10	1789	c.1453C>T	c.(1453-1455)CAG>TAG	p.Q485*	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Nonsense_Mutation_p.Q325*	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	485					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCCAGCGCCCCAGCTGCCTCT	0.647													23	59					0	0	0	0	T	35609311	T	T	35609311	4	4	166	1	0	0	0	0	0	1	0	0	15833	595	21	4	1491	4	TESK1	9	35609311	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	51339	35609311	105604120	543	30871											
SPAG8	26206	broad.mit.edu	37	chr9	35809452	35809452	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactcctgtaaacccccattCtttccaagtcagatagtctt	10	13	5	13	0	3	1	1	0	2	1	5	2	5	1	4	0	1	1	4	0	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35809452C>A	uc003zye.2	-	7	1436	c.1321G>T	c.(1321-1323)GAA>TAA	p.E441*	NPR2_uc003zyd.2_3'UTR|NPR2_uc010mlb.2_3'UTR	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	Error:Variant_position_missing_in_Q99932_after_alignment						acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			AACCCCCATTCTTTCCAAGTC	0.493													99	244					3.37413e-40	8.52228e-40	1	0	A	35809452	A	A	35809452	4	1	166	1	0	0	0	0	0	1	0	0	15050	922	32	2	192	2	SPAG8	9	35809452	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	200141	35809452	105403979	544	30872											
PAX5	5079	broad.mit.edu	37	chr9	36846845	36846845	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgccagtactcaccaagcAgccccgggttggggaacctc	8	6	11	16	2	1	0	1	0	0	0	3	1	2	1	6	3	4	3	6	3	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:36846845A>T	uc003zzo.1	-	9	1542	c.1094T>A	c.(1093-1095)CTG>CAG	p.L365Q	PAX5_uc011lpt.1_Missense_Mutation_p.L161Q|PAX5_uc011lpu.1_RNA|PAX5_uc011lpv.1_Intron|PAX5_uc011lpw.1_Intron|PAX5_uc011lpx.1_Missense_Mutation_p.L265Q|PAX5_uc011lpy.1_Intron|PAX5_uc010mls.1_Intron|PAX5_uc011lpz.1_Missense_Mutation_p.L322Q|PAX5_uc011lqa.1_Missense_Mutation_p.L257Q|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.L331Q|PAX5_uc010mlp.1_Intron|PAX5_uc011lqc.1_Intron|PAX5_uc010mlr.1_Missense_Mutation_p.C288S	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	365					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(11)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CTCACCAAGCAGCCCCGGGTT	0.632			T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								9	23					0	0	0	0	T	36846845	T	T	36846845	3	4	166	1	0	0	0	0	1	0	0	0	11536	188	7	5	89	5	PAX5	9	36846845	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1037393	36846845	104366586	545	30873											
FBXO10	26267	broad.mit.edu	37	chr9	37531943	37531943	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actttttccggatgtctacaCcagcctctgcattgtggtaa	8	14	8	11	1	2	0	0	0	2	0	3	1	3	1	3	2	3	2	3	2	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:37531943C>G	uc004aab.2	-	4	1581	c.1532G>C	c.(1531-1533)GGT>GCT	p.G511A	FBXO10_uc004aac.2_Missense_Mutation_p.G527A|FBXO10_uc004aad.2_Missense_Mutation_p.G61A	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	511	PbH1 6.					ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		GATGTCTACACCAGCCTCTGC	0.493													12	42					0	0	0	0	G	37531943	G	G	37531943	3	3	166	1	0	0	0	0	1	0	0	0	5758	507	18	4	1370	4	FBXO10	9	37531943	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	685098	37531943	103681488	546	30874											
FRMPD1	22844	broad.mit.edu	37	chr9	37745967	37745967	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctctgccagtctcagggtggCcacatctttgggttttgcag	5	13	12	11	0	3	0	1	0	3	0	4	0	3	0	2	3	2	2	2	3	0	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:37745967C>A	uc004aag.1	+	16	3982	c.3938C>A	c.(3937-3939)GCC>GAC	p.A1313D	FRMPD1_uc004aah.1_Missense_Mutation_p.A1313D	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1313						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CTCAGGGTGGCCACATCTTTG	0.532													33	91					1.08312e-15	2.36142e-15	1	0	A	37745967	A	A	37745967	3	1	166	1	0	0	0	0	1	0	0	0	6091	739	26	4	3996	4	FRMPD1	9	37745967	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	214024	37745967	103467464	547	30875											
C9orf71	169693	broad.mit.edu	37	chr9	71152371	71152371	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagctctgcttttccaccTcaaggctctcttcataagct	8	13	6	14	0	4	0	2	0	2	0	6	1	5	0	2	1	3	4	2	1	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:71152371T>A	uc004agt.2	-	2	370	c.317A>T	c.(316-318)GAG>GTG	p.E106V	uc004ags.1_RNA	NM_153237	NP_694969	Q8N6L7	CI071_HUMAN	hypothetical protein LOC169693	106						integral to membrane					0						CTTTTCCACCTCAAGGCTCTC	0.498													16	40					0	0	0	0	A	71152371	A	A	71152371	3	1	166	1	0	0	0	0	1	0	0	0	2506	1551	54	5	199	5	C9orf71	9	71152371	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	33406404	71152371	70061060	548	30876											
TJP2	9414	broad.mit.edu	37	chr9	71835869	71835869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccctcccctggatcaggatGaccgggcttttgaggtgatg	6	10	14	11	1	1	3	1	3	0	0	2	5	2	5	4	4	0	1	4	4	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:71835869G>A	uc004ahe.2	+	5	609	c.409G>A	c.(409-411)GAC>AAC	p.D137N	TJP2_uc011lrs.1_Missense_Mutation_p.D114N|TJP2_uc004ahb.1_Missense_Mutation_p.D114N|TJP2_uc011lrt.1_Missense_Mutation_p.D114N|TJP2_uc004ahd.2_Missense_Mutation_p.D137N|TJP2_uc004ahf.2_Missense_Mutation_p.D137N|TJP2_uc011lru.1_Missense_Mutation_p.D141N|TJP2_uc011lrv.1_Missense_Mutation_p.D159N	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	137					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						GGATCAGGATGACCGGGCTTT	0.612													7	22					0	0	0	0	A	71835869	A	A	71835869	3	1	166	1	0	0	0	0	1	0	0	0	15996	1290	45	2	584	2	TJP2	9	71835869	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	683498	71835869	69377562	549	30877											
RORB	6096	broad.mit.edu	37	chr9	77282809	77282809	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttctcatctgctgttctgaTatctccaggtagggcagtct	6	15	10	10	0	5	1	1	1	5	0	7	1	5	1	1	2	1	5	1	2	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:77282809T>A	uc004aji.2	+	8	1185	c.1136T>A	c.(1135-1137)ATA>AAA	p.I379K	RORB_uc004ajh.2_Missense_Mutation_p.I368K	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	379	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GCTGTTCTGATATCTCCAGGT	0.413													12	56					0	0	0	0	A	77282809	A	A	77282809	3	1	166	1	0	0	0	0	1	0	0	0	13594	1406	49	5	1133	5	RORB	9	77282809	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5446940	77282809	63930622	550	30878											
FOXB2	442425	broad.mit.edu	37	chr9	79635323	79635323	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaccctacgggctgggctcGgccgccgccgctgccgccgc	2	4	14	21	7	0	0	0	0	0	0	1	0	0	0	7	3	2	3	7	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:79635323G>T	uc004ako.1	+	1	753	c.753G>T	c.(751-753)TCG>TCT	p.S251S		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	251					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						GGCTGGGCTCGgccgccgccg	0.388													7	17					2.7689e-08	5.14411e-08	1	0	T	79635323	T	T	79635323	2	4	166	1	0	0	0	0	0	0	0	1	6025	1103	39	3		3	FOXB2	9	79635323	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2352514	79635323	61578108	551	30879											
FLJ46321	389763	broad.mit.edu	37	chr9	84606419	84606419	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctctgccccaacaatcaaagGcattgaccattcacaccttg	12	9	5	15	0	3	1	2	1	1	0	3	1	3	1	4	1	2	1	4	1	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:84606419G>T	uc004amn.2	+	4	1081	c.1034G>T	c.(1033-1035)GGC>GTC	p.G345V		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	345						integral to membrane					0						ACAATCAAAGGCATTGACCAT	0.458													39	84					1.07121e-22	2.57616e-22	1	0	T	84606419	T	T	84606419	3	4	166	1	0	0	0	0	1	0	0	0	5964	1203	42	4	1048	4	FLJ46321	9	84606419	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4971096	84606419	56607012	552	30880											
FLJ46321	389763	broad.mit.edu	37	chr9	84608333	84608333	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacaagctcagtccccatccTtgatcgtcctcaccctgtct	8	11	5	17	1	3	1	2	1	1	0	7	1	6	1	5	0	2	1	5	0	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:84608333T>C	uc004amn.2	+	4	2995	c.2948T>C	c.(2947-2949)CTT>CCT	p.L983P		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	983						integral to membrane					0						GTCCCCATCCTTGATCGTCCT	0.488													67	124					0	0	0	0	C	84608333	C	C	84608333	3	2	166	1	0	0	0	0	1	0	0	0	5964	1609	56	5	2962	5	FLJ46321	9	84608333	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1914	84608333	56605098	553	30881											
FLJ46321	389763	broad.mit.edu	37	chr9	84608809	84608809	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ataatgtagacaggcttcagGgcagtagaaagacctttcct	13	10	10	8	0	1	3	1	0	0	3	2	3	2	3	2	2	0	4	2	2	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:84608809G>T	uc004amn.2	+	4	3471	c.3424G>T	c.(3424-3426)GGC>TGC	p.G1142C		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1142						integral to membrane					0						CAGGCTTCAGGGCAGTAGAAA	0.468													21	30					1.00905e-13	2.09728e-13	1	0	T	84608809	T	T	84608809	3	4	166	1	0	0	0	0	1	0	0	0	5964	1232	43	4	3438	4	FLJ46321	9	84608809	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	476	84608809	56604622	554	30882											
NOL8	55035	broad.mit.edu	37	chr9	95076834	95076834	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagctgtctttgtcaaagccTatgttgtgagtctttgcact	7	16	9	9	0	3	1	1	1	2	0	3	1	3	1	1	0	3	3	1	0	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:95076834T>C	uc004arv.2	-	7	2410	c.2073A>G	c.(2071-2073)ATA>ATG	p.I691M	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.I623M	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	691					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						TGTCAAAGCCTATGTTGTGAG	0.438													7	52					0	0	0	0	C	95076834	C	C	95076834	3	2	166	1	0	0	0	0	1	0	0	0	10581	1512	53	5	1474	5	NOL8	9	95076834	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	10468025	95076834	46136597	555	30883											
SUSD3	203328	broad.mit.edu	37	chr9	95846964	95846964	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acatggcaaaccccagacagCccctgcctgcctctgggctg	8	6	10	17	0	1	1	0	0	1	1	1	1	1	1	6	2	4	2	6	2	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:95846964C>G	uc004atb.2	+	5	739	c.703C>G	c.(703-705)CCC>GCC	p.P235A	SUSD3_uc004atc.2_Missense_Mutation_p.P222A	NM_145006	NP_659443	Q96L08	SUSD3_HUMAN	sushi domain containing 3	235	Cytoplasmic (Potential).					integral to membrane				breast(2)|skin(2)|ovary(1)|lung(1)	6						CCCCAGACAGCCCCTGCCTGC	0.637													52	157					0	0	0	0	G	95846964	G	G	95846964	3	3	166	1	0	0	0	0	1	0	0	0	15475	739	26	4	721	4	SUSD3	9	95846964	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	770130	95846964	45366467	556	30884											
WNK2	65268	broad.mit.edu	37	chr9	96025977	96025977	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccacgcgtgcgcgctcccgGcaggagagggccagccggcc	5	3	16	17	6	0	1	0	0	0	1	2	2	2	1	5	4	2	2	5	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:96025977G>T	uc004ati.1	+	14	3540	c.3540G>T	c.(3538-3540)CGG>CGT	p.R1180R	WNK2_uc011lud.1_Silent_p.R1180R|WNK2_uc004atj.2_Silent_p.R1180R|WNK2_uc004atk.2_Silent_p.R817R	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1180					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CGCGCTCCCGGCAGGAGAGGG	0.537													6	9					5.9392e-07	1.06503e-06	1	0	T	96025977	T	T	96025977	2	4	166	1	0	0	0	0	0	0	0	1	17446	1190	42	4		4	WNK2	9	96025977	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	179013	96025977	45187454	557	30885											
PTPDC1	138639	broad.mit.edu	37	chr9	96859788	96859788	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgtgatcccaaagcacatGctgtcaccttacctcaatat	11	11	6	13	0	2	1	2	1	0	0	3	1	3	1	3	0	3	3	3	0	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:96859788G>T	uc004auf.1	+	7	1118	c.778G>T	c.(778-780)GCT>TCT	p.A260S	PTPDC1_uc004aug.1_Missense_Mutation_p.A260S|PTPDC1_uc004auh.1_Missense_Mutation_p.A312S|PTPDC1_uc010mrj.1_Missense_Mutation_p.A314S|PTPDC1_uc010mri.1_Missense_Mutation_p.A312S	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	260							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1						CAAAGCACATGCTGTCACCTT	0.438													129	76					1.6185e-62	4.13593e-62	1	0	T	96859788	T	T	96859788	3	4	166	1	0	0	0	0	1	0	0	0	12836	1319	46	4	1042	4	PTPDC1	9	96859788	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	833811	96859788	44353643	558	30886											
GABBR2	9568	broad.mit.edu	37	chr9	101216274	101216274	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggactgaccgtgaccccgaAgaagttggtctcgttcatgg	8	9	14	10	3	2	3	1	2	1	1	3	5	2	4	3	3	0	2	3	3	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:101216274A>G	uc004ays.2	-	7	1381	c.1225T>C	c.(1225-1227)TTC>CTC	p.F409L		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	409	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GTGACCCCGAAGAAGTTGGTC	0.532													73	70					0	0	0	0	G	101216274	G	G	101216274	3	3	166	1	0	0	0	0	1	0	0	0	6190	72	3	5	1652	5	GABBR2	9	101216274	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	4356486	101216274	39997157	559	30887											
CYLC2	1539	broad.mit.edu	37	chr9	105765547	105765547	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgggacaacacggtttctgTaagcattggaaagattttat	13	12	10	6	2	1	1	0	0	1	1	1	3	1	3	0	3	2	3	0	3	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:105765547T>C	uc004bbs.2	+	3	250	c.180_splice	c.e3+2	p.S60_splice		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2						cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				ACGGTTTCTGTAAGCATTGGA	0.284													16	52					0	0	0	0	C	105765547	C	C	105765547	5	2	166	1	0	0	0	0	0	0	1	0	4159	1652	57	5	192	5	CYLC2	9	105765547	Splice_Site	SNP	T	TCGA-CR-7402-01A-11D-2012-08	4549273	105765547	35447884	560	30888											
OR13C9	286362	broad.mit.edu	37	chr9	107379790	107379790	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaagctttgcttctcccCtcagaggagtgaatcttgag	10	11	11	9	0	3	4	1	2	2	2	4	6	3	5	2	1	2	2	2	1	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:107379790C>T	uc011lvr.1	-	1	696	c.696G>A	c.(694-696)GAG>GAA	p.E232E		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCTTCTCCCCTCAGAGGAGT	0.428													19	85					0	0	0	0	T	107379790	T	T	107379790	2	4	166	1	0	0	0	0	0	0	0	1	10993	680	24	4		4	OR13C9	9	107379790	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1614243	107379790	33833641	561	30889											
RGS3	5998	broad.mit.edu	37	chr9	116353656	116353656	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggatgatgacgaagcctcccGgaagagaaagagcaaaaacc	17	3	12	9	2	0	4	0	2	0	2	1	8	1	6	3	2	3	1	3	2	5	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:116353656G>T	uc004bhq.2	+	22	3268	c.3059G>T	c.(3058-3060)CGG>CTG	p.R1020L	RGS3_uc004bhs.2_Missense_Mutation_p.R910L|RGS3_uc004bht.2_Missense_Mutation_p.R739L|RGS3_uc010muy.2_Missense_Mutation_p.R413L|RGS3_uc004bhv.2_Missense_Mutation_p.R341L|RGS3_uc010muz.1_Missense_Mutation_p.R359L|RGS3_uc004bhw.2_Intron|RGS3_uc011lxh.1_Missense_Mutation_p.R330L|RGS3_uc004bhx.2_Missense_Mutation_p.R341L|RGS3_uc004bhy.1_Missense_Mutation_p.R330L|RGS3_uc004bhz.2_Missense_Mutation_p.R362L|RGS3_uc004bia.2_5'Flank	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	1020					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						GAAGCCTCCCGGAAGAGAAAG	0.587													24	63					2.44723e-14	5.18548e-14	1	0	T	116353656	T	T	116353656	3	4	166	1	0	0	0	0	1	0	0	0	13371	1116	39	3	3394	3	RGS3	9	116353656	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	8973866	116353656	24859775	562	30890											
ORM2	5005	broad.mit.edu	37	chr9	117092788	117092788	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagtcggttcaggagatccaAgcaaccttcttttactttac	11	13	7	10	1	2	1	1	0	1	1	4	2	3	1	2	2	4	2	2	2	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:117092788A>T	uc004bil.2	+	2	305	c.189A>T	c.(187-189)CAA>CAT	p.Q63H	ORM1_uc011lxo.1_Intron	NM_000608	NP_000599	P19652	A1AG2_HUMAN	orosomucoid 2 precursor	63					acute-phase response|regulation of immune system process|transport	extracellular space	binding				0		Myeloproliferative disorder(63;0.163)				AGGAGATCCAAGCAACCTTCT	0.512													28	48					0	0	0	0	T	117092788	T	T	117092788	3	4	166	1	0	0	0	0	1	0	0	0	11322	69	3	5	195	5	ORM2	9	117092788	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	739132	117092788	24120643	563	30891											
TNC	3371	broad.mit.edu	37	chr9	117849088	117849088	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgagctcactgcagtcttCgcccgtgaaaccctcatcac	9	9	8	15	2	4	2	3	2	1	0	5	3	4	2	2	0	3	2	2	0	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:117849088C>A	uc004bjj.3	-	3	1284	c.922G>T	c.(922-924)GAA>TAA	p.E308*	TNC_uc010mvf.2_Nonsense_Mutation_p.E308*	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	308	EGF-like 5.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						CTGCAGTCTTCGCCCGTGAAA	0.557													53	79					2.12129e-23	5.12666e-23	1	0	A	117849088	A	A	117849088	4	1	166	1	0	0	0	0	0	1	0	0	16336	893	31	3	5787	3	TNC	9	117849088	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	756300	117849088	23364343	564	30892											
PAPPA	5069	broad.mit.edu	37	chr9	118950331	118950331	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgacgggccacgacggcggGgattgccgccacctgcgcca	6	4	15	16	6	0	1	0	1	0	0	0	3	0	2	5	4	2	0	5	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:118950331G>T	uc004bjn.2	+	2	1695	c.1314G>T	c.(1312-1314)GGG>GGT	p.G438G	PAPPA_uc011lxp.1_Silent_p.G231G|PAPPA_uc011lxq.1_Silent_p.G231G	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	438	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						ACGACGGCGGGGATTGCCGCC	0.597													17	62					1.45105e-14	3.09137e-14	1	0	T	118950331	T	T	118950331	2	4	166	1	0	0	0	0	0	0	0	1	11486	1219	43	4		4	PAPPA	9	118950331	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1101243	118950331	22263100	565	30893											
ASTN2	23245	broad.mit.edu	37	chr9	119976723	119976723	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgccaaactcgtcctcgCgggagacatggttggcccgc	6	7	14	14	4	0	1	0	0	0	1	3	2	1	1	3	4	2	2	3	4	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:119976723C>A	uc004bjs.1	-	3	1030	c.929G>T	c.(928-930)CGC>CTC	p.R310L	ASTN2_uc004bjr.1_Missense_Mutation_p.R310L|ASTN2_uc004bjt.1_Missense_Mutation_p.R310L	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	310	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CTCGTCCTCGCGGGAGACATG	0.577													28	93					2.65835e-16	5.88741e-16	1	0	A	119976723	A	A	119976723	3	1	166	1	0	0	0	0	1	0	0	0	1067	768	27	3	3249	3	ASTN2	9	119976723	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1026392	119976723	21236708	566	30894											
DBC1	1620	broad.mit.edu	37	chr9	122075568	122075568	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagctggttcctggtgggaGggctgcactgagatacggcc	6	8	16	11	1	0	1	0	1	0	1	1	3	1	2	3	5	3	4	3	5	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:122075568G>A	uc004bkc.2	-	2	522	c.66C>T	c.(64-66)CCC>CCT	p.P22P	DBC1_uc004bkd.2_Silent_p.P22P	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	22					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CCTGGTGGGAGGGCTGCACTG	0.512													43	54					0	0	0	0	A	122075568	A	A	122075568	2	1	166	1	0	0	0	0	0	0	0	1	4264	987	35	4		4	DBC1	9	122075568	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2098845	122075568	19137863	567	30895											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123177356	123177356	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgccgttccaactgtttcCgtagcttctcatttgtttta	5	19	6	11	2	1	0	1	0	1	0	4	0	3	0	3	0	3	5	3	0	3	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:123177356C>G	uc004bkf.2	-	28	4440	c.4259G>C	c.(4258-4260)CGG>CCG	p.R1420P	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.R429P|CDK5RAP2_uc004bke.2_Missense_Mutation_p.R705P|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.R1420P|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.R685P|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.R685P|CDK5RAP2_uc011lya.1_Missense_Mutation_p.R685P|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.R1190P|CDK5RAP2_uc004bki.2_Missense_Mutation_p.R1187P	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1420					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CAACTGTTTCCGTAGCTTCTC	0.408													23	93					0	0	0	0	G	123177356	G	G	123177356	3	3	166	1	0	0	0	0	1	0	0	0	3161	652	23	3	1466	3	CDK5RAP2	9	123177356	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1101788	123177356	18036075	568	30896											
CEP110	11064	broad.mit.edu	37	chr9	123875817	123875817	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agccccagatgaaagcccttAcattggcaaatccagataca	15	7	7	12	0	0	3	0	1	0	2	1	3	1	3	4	1	4	1	4	1	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:123875817A>G	uc004bkx.1	+	8	1191	c.1160A>G	c.(1159-1161)TAC>TGC	p.Y387C	CEP110_uc004bkw.2_Missense_Mutation_p.Y387C|CEP110_uc004bky.1_5'UTR	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	387					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						GAAAGCCCTTACATTGGCAAA	0.358													26	64					0	0	0	0	G	123875817	G	G	123875817	3	3	166	1	0	0	0	0	1	0	0	0	3260	391	14	5	1190	5	CEP110	9	123875817	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	698461	123875817	17337614	569	30897											
RBM18	92400	broad.mit.edu	37	chr9	125004254	125004254	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aataaacaggcgctgctggaTactctgcatcaggattttcc	11	11	9	10	1	2	0	1	0	1	0	3	2	3	2	1	3	4	3	1	3	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:125004254T>G	uc004bma.2	-	6	648	c.482A>C	c.(481-483)TAT>TCT	p.Y161S	RBM18_uc004blz.2_RNA|RBM18_uc010mvy.2_RNA|RBM18_uc011lyp.1_RNA	NM_033117	NP_149108	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	161							nucleotide binding|RNA binding				0						CGCTGCTGGATACTCTGCATC	0.408													18	62					0	0	0	0	G	125004254	G	G	125004254	3	3	166	1	0	0	0	0	1	0	0	0	13185	1406	49	5	94	5	RBM18	9	125004254	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1128437	125004254	16209177	570	30898											
PTGS1	5742	broad.mit.edu	37	chr9	125154751	125154751	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacaccaagacctgtccctaCgtttccttccgtgtgccgga	8	10	8	15	3	0	1	0	0	0	1	3	2	3	2	6	1	3	1	6	1	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:125154751C>A	uc004bmg.1	+	11	1863	c.1728C>A	c.(1726-1728)TAC>TAA	p.Y576*	PTGS1_uc011lys.1_Nonsense_Mutation_p.Y514*|PTGS1_uc010mwb.1_Nonsense_Mutation_p.Y430*|PTGS1_uc004bmf.1_Nonsense_Mutation_p.Y539*|PTGS1_uc004bmh.1_Nonsense_Mutation_p.Y467*|PTGS1_uc011lyt.1_Nonsense_Mutation_p.Y467*	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	576					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	CCTGTCCCTACGTTTCCTTCC	0.582													31	100					2.61193e-14	5.52253e-14	1	0	A	125154751	A	A	125154751	4	1	166	1	0	0	0	0	0	1	0	0	12818	547	19	3	1770	3	PTGS1	9	125154751	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	150497	125154751	16058680	571	30899											
OR1L6	392390	broad.mit.edu	37	chr9	125512443	125512443	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccagatgtacttctttaTggcatttgggaacactgaca	10	12	10	9	0	1	2	0	1	1	1	1	3	1	3	1	3	2	2	1	3	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:125512443T>C	uc011lzc.1	+	1	425	c.425T>C	c.(424-426)ATG>ACG	p.M142T		NM_001004453	NP_001004453	Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L,	142	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TACTTCTTTATGGCATTTGGG	0.488													34	148					0	0	0	0	C	125512443	C	C	125512443	3	2	166	1	0	0	0	0	1	0	0	0	11020	1464	51	5	319	5	OR1L6	9	125512443	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	357692	125512443	15700988	572	30900											
LRSAM1	90678	broad.mit.edu	37	chr9	130241717	130241717	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgcctggaactggggcagcGggagcacacccagctccttc	7	5	14	15	2	0	0	0	0	0	0	2	2	1	2	3	4	4	3	3	4	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:130241717G>T	uc004brb.1	+	13	1181	c.836G>T	c.(835-837)CGG>CTG	p.R279L	LRSAM1_uc010mxk.1_Missense_Mutation_p.R279L|LRSAM1_uc004brc.1_Missense_Mutation_p.R279L|LRSAM1_uc004brd.1_Missense_Mutation_p.R279L|LRSAM1_uc004bre.1_5'UTR	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	279	Potential.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						CTGGGGCAGCGGGAGCACACC	0.602													29	32					7.01153e-11	1.3784e-10	1	0	T	130241717	T	T	130241717	3	4	166	1	0	0	0	0	1	0	0	0	9093	1116	39	3	878	3	LRSAM1	9	130241717	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4729274	130241717	10971714	573	30901											
SH2D3C	10044	broad.mit.edu	37	chr9	130506941	130506941	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggcccacctccagtggccGgttatccctggggatcagta	8	8	12	13	1	1	0	1	0	0	0	3	1	3	1	5	5	0	2	5	5	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:130506941G>T	uc004bsc.2	-	7	1844	c.1702C>A	c.(1702-1704)CGG>AGG	p.R568R	SH2D3C_uc010mxo.2_Silent_p.R408R|SH2D3C_uc004bry.2_Silent_p.R410R|SH2D3C_uc004brz.3_Silent_p.R214R|SH2D3C_uc011mak.1_Silent_p.R214R|SH2D3C_uc004bsa.2_Silent_p.R411R|SH2D3C_uc004bsb.2_Silent_p.R500R	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	568					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						TCCAGTGGCCGGTTATCCCTG	0.612													48	135					5.34276e-22	1.27394e-21	1	0	T	130506941	T	T	130506941	2	4	166	1	0	0	0	0	0	0	0	1	14299	1115	39	3		3	SH2D3C	9	130506941	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	265224	130506941	10706490	574	30902											
LAMC3	10319	broad.mit.edu	37	chr9	133946978	133946978	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgctgggagaggccccaagGggggacgtctaccagggcca	8	4	17	12	1	1	1	0	0	1	1	1	3	1	2	4	6	2	1	4	6	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:133946978G>A	uc004caa.1	+	18	3275	c.3177G>A	c.(3175-3177)AGG>AGA	p.R1059R		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1059	Cell attachment site (Potential).|Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		AGGCCCCAAGGGGGGACGTCT	0.657													26	38					0	0	0	0	A	133946978	A	A	133946978	2	1	166	1	0	0	0	0	0	0	0	1	8656	1223	43	4		4	LAMC3	9	133946978	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3440037	133946978	7266453	575	30903											
NUP214	8021	broad.mit.edu	37	chr9	134021593	134021593	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcgccattctcttctgcctCcaagccagctgcttctggac	5	12	8	16	1	3	0	0	0	3	0	6	1	4	1	4	1	4	2	4	1	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:134021593C>A	uc004cag.2	+	13	1958	c.1847C>A	c.(1846-1848)TCC>TAC	p.S616Y	NUP214_uc004cah.2_Missense_Mutation_p.S605Y|NUP214_uc004cai.2_Missense_Mutation_p.S45Y|NUP214_uc004caf.1_Missense_Mutation_p.S605Y|NUP214_uc010mzf.2_5'UTR	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	616	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TCTTCTGCCTCCAAGCCAGCT	0.567			T	DEK|SET|ABL1	AML|T-ALL								231	318					1.95565e-89	5.02368e-89	1	0	A	134021593	A	A	134021593	3	1	166	1	0	0	0	0	1	0	0	0	10816	855	30	2	1897	2	NUP214	9	134021593	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	74615	134021593	7191838	576	30904											
BAT2L1	84726	broad.mit.edu	37	chr9	134350269	134350269	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccatcctcggagcctgaatGgactcccgagccccggagct	7	6	12	16	3	0	1	0	1	0	0	3	5	2	4	6	3	3	1	6	3	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:134350269G>T	uc004can.3	+	15	2808	c.2753G>T	c.(2752-2754)TGG>TTG	p.W918L	BAT2L1_uc010mzj.1_Missense_Mutation_p.W501L|BAT2L1_uc004cao.3_Missense_Mutation_p.W276L	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	918							protein binding				0						GAGCCTGAATGGACTCCCGAG	0.642													8	8					5.18039e-06	9.03342e-06	1	0	T	134350269	T	T	134350269	3	4	166	1	0	0	0	0	1	0	0	0	1322	1357	47	4	2811	4	BAT2L1	9	134350269	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	328676	134350269	6863162	577	30905											
POMT1	10585	broad.mit.edu	37	chr9	134394277	134394277	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggcaactggagatcgtcggGgagaagctgtcccggggcta	8	6	17	10	4	0	2	0	0	0	2	3	4	1	2	1	6	2	3	1	6	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:134394277G>A	uc004cav.2	+	15	1687	c.1485G>A	c.(1483-1485)GGG>GGA	p.G495G	POMT1_uc004cax.2_Silent_p.G473G|POMT1_uc011mcj.1_Silent_p.G251G|POMT1_uc004cau.2_Silent_p.G473G|POMT1_uc004caw.2_Silent_p.G419G|POMT1_uc011mck.1_Silent_p.G356G|POMT1_uc011mcl.1_Silent_p.G321G|POMT1_uc011mcm.1_Silent_p.G443G|POMT1_uc011mcn.1_3'UTR	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	495	MIR 3.				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		AGATCGTCGGGGAGAAGCTGT	0.677													22	47					0	0	0	0	A	134394277	A	A	134394277	2	1	166	1	0	0	0	0	0	0	0	1	12300	1219	43	4		4	POMT1	9	134394277	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	44008	134394277	6819154	578	30906											
SURF2	6835	broad.mit.edu	37	chr9	136226863	136226863	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggggtggagtacgtgccTgcctgcctggtgcaccggag	6	7	17	11	2	0	0	0	0	0	0	0	2	0	2	4	5	5	2	4	5	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:136226863T>C	uc004cdi.2	+	4	423	c.375T>C	c.(373-375)CCT>CCC	p.P125P		NM_017503	NP_059973	Q15527	SURF2_HUMAN	surfeit 2	125							protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		AGTACGTGCCTGCCTGCCTGG	0.647													9	23					0	0	0	0	C	136226863	C	C	136226863	2	2	166	1	0	0	0	0	0	0	0	1	15470	1567	55	5		5	SURF2	9	136226863	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1832586	136226863	4986568	579	30907											
SEC16A	9919	broad.mit.edu	37	chr9	139353630	139353630	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggcacccagggactgggCgtactcataggcttccgtcc	6	8	12	15	3	1	0	1	0	0	0	4	1	3	1	3	4	1	3	3	4	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:139353630C>G	uc004chx.2	-	17	5674	c.5365G>C	c.(5365-5367)GCC>CCC	p.A1789P	SEC16A_uc004chu.2_5'Flank|SEC16A_uc004chv.3_Missense_Mutation_p.A1179P|SEC16A_uc004chw.2_Missense_Mutation_p.A1789P|SEC16A_uc010nbn.2_Missense_Mutation_p.A1789P	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1611					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		AGGGACTGGGCGTACTCATAG	0.522													60	65					0	0	0	0	G	139353630	G	G	139353630	3	3	166	1	0	0	0	0	1	0	0	0	14051	768	27	3	1772	3	SEC16A	9	139353630	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3126767	139353630	1859801	580	30908											
CUBN	8029	broad.mit.edu	37	chr10	16946023	16946023	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacgttcgttggtgacaaaGtgaatccatacctgagaata	14	10	9	8	2	0	3	0	3	0	1	2	4	1	3	2	1	1	2	2	1	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:16946023G>T	uc001ioo.2	-	51	8056	c.8004C>A	c.(8002-8004)CAC>CAA	p.H2668Q	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.H24Q	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2668	CUB 19.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGGTGACAAAGTGAATCCATA	0.378													11	25					2.80697e-09	5.31049e-09	1	0	T	16946023	T	T	16946023	3	4	166	1	0	0	0	0	1	0	0	0	4068	1020	36	4	2935	4	CUBN	10	16946023	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08		16946023	118588724	581	30909											
CUBN	8029	broad.mit.edu	37	chr10	17126346	17126346	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatttgtatttgttctcccTggggctgcttcatcatatag	6	18	9	8	0	3	1	2	1	1	0	4	1	3	1	1	2	1	4	1	2	3	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:17126346T>A	uc001ioo.2	-	17	2277	c.2225A>T	c.(2224-2226)CAG>CTG	p.Q742L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	742	CUB 3.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGTTCTCCCTGGGGCTGCTT	0.498													21	41					0	0	0	0	A	17126346	A	A	17126346	3	1	166	1	0	0	0	0	1	0	0	0	4068	1580	55	5	8850	5	CUBN	10	17126346	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	180323	17126346	118408401	582	30910											
CUBN	8029	broad.mit.edu	37	chr10	17168764	17168764	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagcatgagacctacctgcTgcaagccttggaattttctc	9	12	9	11	0	1	1	0	1	1	1	2	3	1	2	3	1	5	4	3	1	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:17168764T>A	uc001ioo.2	-	4	435	c.383A>T	c.(382-384)CAG>CTG	p.Q128L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	128					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCTACCTGCTGCAAGCCTTG	0.393													20	30					0	0	0	0	A	17168764	A	A	17168764	3	1	166	1	0	0	0	0	1	0	0	0	4068	1580	55	5	10744	5	CUBN	10	17168764	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	42418	17168764	118365983	583	30911											
CACNB2	783	broad.mit.edu	37	chr10	18690910	18690910	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccgatgtatctctggaggagGaccgggaggcagtgcgcaga	9	6	17	9	3	1	1	0	0	1	1	2	6	1	5	2	5	1	3	2	5	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:18690910G>T	uc001ipr.2	+	3	331	c.271G>T	c.(271-273)GAC>TAC	p.D91Y	CACNB2_uc009xjz.1_Missense_Mutation_p.D91Y|CACNB2_uc001ips.2_Missense_Mutation_p.D91Y|CACNB2_uc001ipt.2_Missense_Mutation_p.D91Y|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Missense_Mutation_p.D63Y|CACNB2_uc001ipv.2_Missense_Mutation_p.D63Y|CACNB2_uc009xka.1_Missense_Mutation_p.D63Y|CACNB2_uc001ipw.2_Missense_Mutation_p.D36Y|CACNB2_uc001ipx.2_Missense_Mutation_p.D36Y|CACNB2_uc009xkb.1_Missense_Mutation_p.D37Y|CACNB2_uc010qcm.1_Missense_Mutation_p.D37Y|CACNB2_uc001ipz.2_Missense_Mutation_p.D37Y|CACNB2_uc001ipy.2_Missense_Mutation_p.D37Y|CACNB2_uc010qcn.1_Missense_Mutation_p.D43Y|CACNB2_uc010qco.1_Missense_Mutation_p.D43Y|CACNB2_uc001iqa.2_Missense_Mutation_p.D43Y	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	91					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCTGGAGGAGGACCGGGAGGC	0.507													11	56					2.80697e-09	5.31049e-09	1	0	T	18690910	T	T	18690910	3	4	166	1	0	0	0	0	1	0	0	0	2565	1174	41	2	501	2	CACNB2	10	18690910	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1522146	18690910	116843837	584	30912											
NEBL	10529	broad.mit.edu	37	chr10	21108419	21108419	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatgcttaccggagtggcCttgtagttttgctctttata	6	17	10	8	1	2	0	1	0	1	0	2	1	2	1	2	2	3	4	2	2	4	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:21108419C>T	uc001iqi.2	-	20	2386	c.1989G>A	c.(1987-1989)AAG>AAA	p.K663K	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	663	Nebulin 18.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CCGGAGTGGCCTTGTAGTTTT	0.438													32	104					0	0	0	0	T	21108419	T	T	21108419	2	4	166	1	0	0	0	0	0	0	0	1	10357	680	24	4		4	NEBL	10	21108419	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2417509	21108419	114426328	585	30913											
ENKUR	219670	broad.mit.edu	37	chr10	25279433	25279433	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcatcggagagccttttcaTagctgctttcttaaggtttt	7	18	8	8	1	3	1	2	0	1	1	4	2	3	1	1	2	3	3	1	2	2	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:25279433T>C	uc001isg.1	-	4	718	c.553A>G	c.(553-555)ATG>GTG	p.M185V	ENKUR_uc001ish.1_Missense_Mutation_p.M123V	NM_145010	NP_659447	Q8TC29	ENKUR_HUMAN	enkurin	185	IQ.					cilium|flagellum	calmodulin binding|SH3 domain binding				0						AGCCTTTTCATAGCTGCTTTC	0.408													22	43					0	0	0	0	C	25279433	C	C	25279433	3	2	166	1	0	0	0	0	1	0	0	0	5144	1406	49	5	229	5	ENKUR	10	25279433	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	4171014	25279433	110255314	586	30914											
YME1L1	10730	broad.mit.edu	37	chr10	27403474	27403474	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaggattcttatttcttgTtcgatggcagattgggtttc	8	17	11	5	1	2	2	0	0	2	2	4	4	2	3	0	3	0	3	0	3	2	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:27403474T>C	uc001iti.2	-	19	2336	c.2154A>G	c.(2152-2154)GAA>GAG	p.E718E	YME1L1_uc001itj.2_Silent_p.E661E|YME1L1_uc010qdl.1_Silent_p.E628E|YME1L1_uc009xkv.2_RNA	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	718					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						TTATTTCTTGTTCGATGGCAG	0.328													12	43					0	0	0	0	C	27403474	C	C	27403474	2	2	166	1	0	0	0	0	0	0	0	1	17555	1722	60	5		5	YME1L1	10	27403474	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2124041	27403474	108131273	587	30915											
LYZL2	119180	broad.mit.edu	37	chr10	30915774	30915774	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atatttttgccagtttgcaaCgagtgtagattttggactcg	9	16	10	6	2	0	1	0	0	0	1	1	3	0	2	1	1	3	3	1	1	3	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:30915774C>G	uc001ivk.2	-	2	222	c.209G>C	c.(208-210)CGT>CCT	p.R70P		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	24					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				CAGTTTGCAACGAGTGTAGAT	0.522													27	49					0	0	0	0	G	30915774	G	G	30915774	3	3	166	1	0	0	0	0	1	0	0	0	9183	536	19	3	391	3	LYZL2	10	30915774	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3512300	30915774	104618973	588	30916											
ZEB1	6935	broad.mit.edu	37	chr10	31815599	31815599	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacagaattcttattttgcaGgtaaaagacctcatgagtgt	14	13	8	6	0	2	3	1	1	1	2	2	3	2	3	1	1	2	2	1	1	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:31815599G>T	uc001ivs.3	+	9	2846	c.2783_splice	c.e9-1	p.G928_splice	ZEB1_uc001ivr.3_Splice_Site_p.G710_splice|ZEB1_uc010qee.1_Splice_Site_p.G710_splice|ZEB1_uc010qef.1_Splice_Site_p.G710_splice|ZEB1_uc001ivt.3_Splice_Site_p.G710_splice|ZEB1_uc001ivu.3_Splice_Site_p.G929_splice|ZEB1_uc001ivv.3_Splice_Site_p.G908_splice|ZEB1_uc010qeh.1_Splice_Site_p.G861_splice|ZEB1_uc009xlp.2_Splice_Site_p.G912_splice	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b						cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				TTATTTTGCAGGTAAAAGACC	0.348													6	19					0.00198382	0.00322679	1	0	T	31815599	T	T	31815599	5	4	166	1	0	0	0	0	0	0	1	0	17690	1014	35	4	2830	4	ZEB1	10	31815599	Splice_Site	SNP	G	TCGA-CR-7402-01A-11D-2012-08	899825	31815599	103719148	589	30917											
PARD3	56288	broad.mit.edu	37	chr10	34666965	34666965	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgggggagaatgtttttcAcatagattggagctgagcca	10	10	13	8	1	1	3	1	1	0	2	1	5	1	4	2	3	2	2	2	3	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:34666965A>T	uc010qej.1	-	10	1469	c.1469T>A	c.(1468-1470)GTG>GAG	p.V490E	PARD3_uc010qek.1_Missense_Mutation_p.V490E|PARD3_uc010qel.1_Missense_Mutation_p.V490E|PARD3_uc010qem.1_Missense_Mutation_p.V490E|PARD3_uc010qen.1_Missense_Mutation_p.V490E|PARD3_uc010qeo.1_Missense_Mutation_p.V490E|PARD3_uc010qep.1_Missense_Mutation_p.V446E|PARD3_uc010qeq.1_Missense_Mutation_p.V446E|PARD3_uc001ixo.1_Missense_Mutation_p.V220E|PARD3_uc001ixp.1_Missense_Mutation_p.V355E|PARD3_uc001ixq.1_Missense_Mutation_p.V490E|PARD3_uc001ixr.1_Missense_Mutation_p.V490E|PARD3_uc001ixt.1_Missense_Mutation_p.V311E|PARD3_uc001ixu.1_Missense_Mutation_p.V446E|PARD3_uc001ixs.1_Missense_Mutation_p.V143E	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	490	PDZ 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				AATGTTTTTCACATAGATTGG	0.478													30	86					0	0	0	0	T	34666965	T	T	34666965	3	4	166	1	0	0	0	0	1	0	0	0	11497	159	6	5	2700	5	PARD3	10	34666965	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2851366	34666965	100867782	590	30918											
ZNF248	57209	broad.mit.edu	37	chr10	38121829	38121829	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctttttactaataattaagcCcgaaatatttttcaaattca	15	17	2	7	1	2	0	2	0	0	0	2	1	2	0	1	0	2	0	1	0	7	10			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:38121829C>A	uc001izd.1	-	6	953	c.454G>T	c.(454-456)GGC>TGC	p.G152C	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Missense_Mutation_p.G152C	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATAATTAAGCCCGAAATATTT	0.323													21	39					2.4624e-09	4.68573e-09	1	0	A	38121829	A	A	38121829	3	1	166	1	0	0	0	0	1	0	0	0	17860	623	22	4	1289	4	ZNF248	10	38121829	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3454864	38121829	97412918	591	30919											
ZNF25	219749	broad.mit.edu	37	chr10	38242024	38242024	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagtgagtatgctgatgtacTatgagggcagacttctggca	10	11	14	6	0	1	4	0	3	1	1	1	5	1	4	0	2	2	5	0	2	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:38242024T>A	uc001ize.1	-	6	507	c.402A>T	c.(400-402)ATA>ATT	p.I134I	ZNF25_uc001izf.1_Silent_p.I98I	NM_145011	NP_659448	P17030	ZNF25_HUMAN	zinc finger protein 25	134	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|central_nervous_system(1)	4		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				GCTGATGTACTATGAGGGCAG	0.398													43	107					0	0	0	0	A	38242024	A	A	38242024	2	1	166	1	0	0	0	0	0	0	0	1	17861	1512	53	5		5	ZNF25	10	38242024	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	120195	38242024	97292723	592	30920											
RET	5979	broad.mit.edu	37	chr10	43595965	43595965	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaagctgtatgtggaccaGgcagccggcacgcccttgct	8	7	14	12	2	0	1	0	0	0	1	0	3	0	2	3	3	3	5	3	3	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:43595965G>T	uc001jal.2	+	2	322	c.132G>T	c.(130-132)CAG>CAT	p.Q44H	RET_uc001jak.1_Missense_Mutation_p.Q44H	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	44	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	ATGTGGACCAGGCAGCCGGCA	0.612		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				19	41					7.21436e-19	1.66551e-18	1	0	T	43595965	T	T	43595965	3	4	166	1	0	0	0	0	1	0	0	0	13300	991	35	4	138	4	RET	10	43595965	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5353941	43595965	91938782	593	30921											
GDF10	2662	broad.mit.edu	37	chr10	48438504	48438504	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgaccatgtcctgggcgctGgggcccaacgtggcggccgc	4	5	17	15	5	0	0	0	0	0	0	1	1	1	0	4	5	1	1	4	5	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:48438504G>A	uc001jfb.2	-	1	663	c.207C>T	c.(205-207)CCC>CCT	p.P69P	GDF10_uc009xnp.2_Silent_p.P69P|GDF10_uc009xnq.1_Silent_p.P69P	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	69					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						CCTGGGCGCTGGGGCCCAACG	0.741													8	14					0	0	0	0	A	48438504	A	A	48438504	2	1	166	1	0	0	0	0	0	0	0	1	6348	1335	47	4		4	GDF10	10	48438504	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4842539	48438504	87096243	594	30922											
FRMPD2	143162	broad.mit.edu	37	chr10	49431169	49431169	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtttgcagcactcactggAgcagcccatagtggctgaca	10	8	12	11	0	1	1	1	1	0	0	1	2	1	2	1	3	4	5	1	3	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:49431169A>T	uc001jgi.2	-	11	1420	c.1313T>A	c.(1312-1314)CTC>CAC	p.L438H	FRMPD2_uc001jgh.2_Missense_Mutation_p.L407H|FRMPD2_uc001jgj.2_Missense_Mutation_p.L416H	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	438	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CACTCACTGGAGCAGCCCATA	0.398													30	59					0	0	0	0	T	49431169	T	T	49431169	3	4	166	1	0	0	0	0	1	0	0	0	6092	304	11	5	2692	5	FRMPD2	10	49431169	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	992665	49431169	86103578	595	30923											
ERCC6	2074	broad.mit.edu	37	chr10	50667067	50667067	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcatctccaccagaaggtCatcgtgttctgtggtgggca	7	12	11	11	1	4	1	2	0	3	1	7	1	4	1	2	3	0	2	2	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:50667067C>G	uc001jhs.3	-	21	4430	c.4276G>C	c.(4276-4278)GAC>CAC	p.D1426H	ERCC6_uc009xod.2_Missense_Mutation_p.D586H|ERCC6_uc010qgr.1_Missense_Mutation_p.D796H|ERCC6_uc001jhr.3_Missense_Mutation_p.D794H	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1426	Ubiquitin-binding domain (UBD).				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						ACCAGAAGGTCATCGTGTTCT	0.527								Direct_reversal_of_damage|NER					25	70					0	0	0	0	G	50667067	G	G	50667067	3	3	166	1	0	0	0	0	1	0	0	0	5241	826	29	2	209	2	ERCC6	10	50667067	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1235898	50667067	84867680	596	30924											
OGDHL	55753	broad.mit.edu	37	chr10	50966454	50966454	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttgtggacactctgggggTtttccaaccaggcgaagtac	8	10	12	11	1	1	0	0	0	1	0	2	2	2	1	3	4	2	2	3	4	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:50966454T>A	uc001jie.2	-	2	327	c.185A>T	c.(184-186)AAC>ATC	p.N62I	OGDHL_uc009xog.2_Missense_Mutation_p.N89I|OGDHL_uc010qgt.1_Missense_Mutation_p.N62I|OGDHL_uc010qgu.1_Intron|OGDHL_uc009xoh.2_Intron	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	62					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						ACTCTGGGGGTTTTCCAACCA	0.662													31	92					0	0	0	0	A	50966454	A	A	50966454	3	1	166	1	0	0	0	0	1	0	0	0	10894	1725	60	5	2935	5	OGDHL	10	50966454	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	299387	50966454	84568293	597	30925											
A1CF	29974	broad.mit.edu	37	chr10	52575947	52575947	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactctccttgcagcatggtGccccttccacctgtgcctcg	4	12	8	17	1	1	0	0	0	1	0	4	0	2	0	6	1	5	2	6	1	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:52575947G>A	uc001jjj.2	-	9	1148	c.960C>T	c.(958-960)GGC>GGT	p.G320G	A1CF_uc010qhn.1_Silent_p.G328G|A1CF_uc001jji.2_Silent_p.G320G|A1CF_uc001jjh.2_Silent_p.G328G|A1CF_uc010qho.1_Silent_p.G328G|A1CF_uc009xov.2_Silent_p.G320G	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	320					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						GCAGCATGGTGCCCCTTCCAC	0.517													12	53					0	0	0	0	A	52575947	A	A	52575947	2	1	166	1	0	0	0	0	0	0	0	1	2	1306	46	4		4	A1CF	10	52575947	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1609493	52575947	82958800	598	30926											
PCDH15	65217	broad.mit.edu	37	chr10	55569197	55569197	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctggctctcttccatgttGtgtatgtaggctcagctgct	4	17	10	10	0	3	0	1	0	2	0	5	0	4	0	1	2	2	7	1	2	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:55569197G>T	uc010qhs.1	-	37	5023	c.4628C>A	c.(4627-4629)ACA>AAA	p.T1543K	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Missense_Mutation_p.T1536K|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTTCCATGTTGTGTATGTAGG	0.398										HNSCC(58;0.16)			52	151					1.35964e-18	3.1278e-18	1	0	T	55569197	T	T	55569197	3	4	166	1	0	0	0	0	1	0	0	0	11565	1377	48	4	1303	4	PCDH15	10	55569197	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2993250	55569197	79965550	599	30927											
PCDH15	65217	broad.mit.edu	37	chr10	56106245	56106245	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggtaccaactggagtgagCtgaaaggaaaaaagatttta	16	9	12	4	0	0	3	0	2	0	1	0	5	0	5	1	3	3	2	1	3	7	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:56106245C>A	uc001jju.1	-	6	870	c.475_splice	c.e6-1	p.L159_splice	PCDH15_uc010qhq.1_Splice_Site_p.L164_splice|PCDH15_uc010qhr.1_Splice_Site_p.L159_splice|PCDH15_uc010qhs.1_Splice_Site_p.L164_splice|PCDH15_uc010qht.1_Splice_Site_p.L159_splice|PCDH15_uc010qhu.1_Splice_Site_p.L159_splice|PCDH15_uc001jjv.1_Splice_Site_p.L137_splice|PCDH15_uc010qhv.1_Splice_Site_p.L159_splice|PCDH15_uc010qhw.1_Splice_Site_p.L159_splice|PCDH15_uc010qhx.1_Splice_Site_p.L159_splice|PCDH15_uc010qhy.1_Splice_Site_p.L164_splice|PCDH15_uc010qhz.1_Splice_Site_p.L159_splice|PCDH15_uc010qia.1_Splice_Site_p.L137_splice|PCDH15_uc010qib.1_Splice_Site_p.L137_splice|PCDH15_uc001jjw.2_Splice_Site_p.L159_splice	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor						equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTGGAGTGAGCTGAAAGGAAA	0.338										HNSCC(58;0.16)			34	89					2.26627e-22	5.41695e-22	1	0	A	56106245	A	A	56106245	5	1	166	1	0	0	0	0	0	0	1	0	11565	811	28	4	7149	4	PCDH15	10	56106245	Splice_Site	SNP	C	TCGA-CR-7402-01A-11D-2012-08	537048	56106245	79428502	600	30928											
ANK3	288	broad.mit.edu	37	chr10	62039399	62039399	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacttgcattggcatcagacTaaaataaaaaagaaacacat	21	8	5	7	0	1	2	1	0	0	2	1	2	1	2	0	1	3	2	0	1	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:62039399T>G	uc001jky.2	-	2	307	c.115_splice	c.e2-1	p.S39_splice	ANK3_uc010qih.1_Splice_Site_p.S22_splice|ANK3_uc001jkz.3_Splice_Site_p.S33_splice|ANK3_uc001jlb.1_Splice_Site	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGCATCAGACTAAAATAAAAA	0.333													25	64					0	0	0	0	G	62039399	G	G	62039399	5	3	166	1	0	0	0	0	0	0	1	0	622	1536	53	5	13521	5	ANK3	10	62039399	Splice_Site	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5933154	62039399	73495348	601	30929											
MYPN	84665	broad.mit.edu	37	chr10	69961674	69961674	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgtgagactggagtgccgCgtgataggcatgcccccacc	7	6	13	15	3	0	2	0	2	0	1	0	4	0	3	5	2	2	1	5	2	1	1	rs139820597	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:69961674C>A	uc001jnm.3	+	19	3767	c.3582C>A	c.(3580-3582)CGC>CGA	p.R1194R	MYPN_uc001jnn.3_Silent_p.R919R|MYPN_uc001jno.3_Silent_p.R1194R|MYPN_uc009xpt.2_Silent_p.R1194R|MYPN_uc010qit.1_Silent_p.R900R|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	1194	Interaction with ACTN.|Ig-like 5.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TGGAGTGCCGCGTGATAGGCA	0.547													34	84					1.56738e-10	3.06899e-10	1	0	A	69961674	A	A	69961674	2	1	166	1	0	0	0	0	0	0	0	1	10151	755	27	3		3	MYPN	10	69961674	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	7922275	69961674	65573073	602	30930											
CDH23	64072	broad.mit.edu	37	chr10	73550138	73550138	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaccagctgctgggtgcccAgagtggcctctttgacatca	7	10	11	13	0	2	2	1	1	1	1	2	2	2	2	3	2	4	2	3	2	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:73550138A>G	uc001jrx.3	+	44	6394	c.6017A>G	c.(6016-6018)CAG>CGG	p.Q2006R		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2006	Cadherin 19.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CTGGGTGCCCAGAGTGGCCTC	0.632													11	36					0	0	0	0	G	73550138	G	G	73550138	3	3	166	1	0	0	0	0	1	0	0	0	3123	188	7	5	6540	5	CDH23	10	73550138	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	3588464	73550138	61984609	603	30931											
KIAA0913	23053	broad.mit.edu	37	chr10	75558105	75558105	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcatcacgggcaagagactCcaatatggtgagggcggcag	11	5	16	9	2	1	2	1	1	0	1	2	3	2	2	1	5	0	3	1	5	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:75558105C>A	uc009xrl.2	+	20	4087	c.4055C>A	c.(4054-4056)TCC>TAC	p.S1352Y	KIAA0913_uc001jve.2_Missense_Mutation_p.S1357Y|KIAA0913_uc001jvf.2_Missense_Mutation_p.S1352Y|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.S787Y|KIAA0913_uc010qkr.1_Missense_Mutation_p.S775Y|KIAA0913_uc001jvj.2_Missense_Mutation_p.S775Y|KIAA0913_uc009xrn.1_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	1352							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					GCAAGAGACTCCAATATGGTG	0.617													20	57					8.00594e-06	1.38864e-05	1	0	A	75558105	A	A	75558105	3	1	166	1	0	0	0	0	1	0	0	0	8239	855	30	2	4148	2	KIAA0913	10	75558105	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2007967	75558105	59976642	604	30932											
MYST4	23522	broad.mit.edu	37	chr10	76788996	76788996	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctggtcactcgaacccaGaggtcttaatggactgtggc	9	9	12	11	1	2	1	1	0	1	1	3	3	2	2	2	4	2	0	2	4	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:76788996G>T	uc001jwn.1	+	18	4907	c.4414G>T	c.(4414-4416)GAG>TAG	p.E1472*	MYST4_uc001jwo.1_Nonsense_Mutation_p.E1180*|MYST4_uc001jwp.1_Nonsense_Mutation_p.E1289*	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1472					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					CTCGAACCCAGAGGTCTTAAT	0.512			T	CREBBP	AML								21	66					1.10513e-12	2.24462e-12	1	0	T	76788996	T	T	76788996	4	4	166	1	0	0	0	0	0	1	0	0	10158	943	33	2	4476	2	MYST4	10	76788996	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1230891	76788996	58745751	605	30933											
KCNMA1	3778	broad.mit.edu	37	chr10	78729807	78729807	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttttttggtgatagtgttGacggctgctcatcttcaact	6	19	9	7	1	3	2	2	2	1	0	3	2	3	2	0	2	2	3	0	2	2	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:78729807G>C	uc001jxn.2	-	20	2462	c.2285C>G	c.(2284-2286)TCA>TGA	p.S762*	KCNMA1_uc001jxj.2_Nonsense_Mutation_p.S708*|KCNMA1_uc001jxk.1_Nonsense_Mutation_p.S380*|KCNMA1_uc009xrt.1_Nonsense_Mutation_p.S553*|KCNMA1_uc001jxl.1_Nonsense_Mutation_p.S387*|KCNMA1_uc001jxo.2_Nonsense_Mutation_p.S704*|KCNMA1_uc001jxm.2_Nonsense_Mutation_p.S704*|KCNMA1_uc001jxq.2_Nonsense_Mutation_p.S707*	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	762	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGATAGTGTTGACGGCTGCTC	0.483													22	84					0	0	0	0	C	78729807	C	C	78729807	4	2	166	1	0	0	0	0	0	1	0	0	8112	1294	45	2	1617	2	KCNMA1	10	78729807	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1940811	78729807	56804940	606	30934											
KCNMA1	3778	broad.mit.edu	37	chr10	78846339	78846339	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aacagagcttcaagctccagGttgggggagatgctacacag	12	7	13	9	0	1	2	1	0	0	2	2	3	2	2	1	3	5	4	1	3	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:78846339G>T	uc001jxn.2	-	11	1524	c.1347C>A	c.(1345-1347)AAC>AAA	p.N449K	KCNMA1_uc001jxj.2_Missense_Mutation_p.N449K|KCNMA1_uc001jxk.1_Missense_Mutation_p.N64K|KCNMA1_uc009xrt.1_Missense_Mutation_p.N269K|KCNMA1_uc001jxl.1_Missense_Mutation_p.N103K|KCNMA1_uc001jxo.2_Missense_Mutation_p.N449K|KCNMA1_uc001jxm.2_Missense_Mutation_p.N449K|KCNMA1_uc001jxq.2_Missense_Mutation_p.N449K	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	449	RCK N-terminal.|Cytoplasmic (Potential).			N -> D (in Ref. 12; AAD31173).	cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CAAGCTCCAGGTTGGGGGAGA	0.468													16	26					8.60227e-14	1.79558e-13	1	0	T	78846339	T	T	78846339	3	4	166	1	0	0	0	0	1	0	0	0	8112	1252	44	4	2607	4	KCNMA1	10	78846339	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	116532	78846339	56688408	607	30935											
NRG3	10718	broad.mit.edu	37	chr10	84745231	84745231	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagactacgaactggccaGcgtagaaaccgaggacagtg	15	4	13	9	3	0	3	0	0	0	3	0	6	0	4	2	2	4	1	2	2	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:84745231G>C	uc001kco.2	+	9	1988	c.1961G>C	c.(1960-1962)AGC>ACC	p.S654T	NRG3_uc010qlz.1_Missense_Mutation_p.S653T|NRG3_uc001kcp.2_Missense_Mutation_p.S457T|NRG3_uc001kcq.2_Missense_Mutation_p.S304T|NRG3_uc001kcr.2_Missense_Mutation_p.S328T	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	678	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GAACTGGCCAGCGTAGAAACC	0.473													17	26					0	0	0	0	C	84745231	C	C	84745231	3	2	166	1	0	0	0	0	1	0	0	0	10703	971	34	4	2239	4	NRG3	10	84745231	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5898892	84745231	50789516	608	30936											
C10orf99	387695	broad.mit.edu	37	chr10	85944465	85944465	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgaggctctgtaaaccatgCaagcttgagccagagccccg	10	7	12	12	1	1	3	0	2	1	1	1	3	1	3	4	1	5	4	4	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:85944465C>A	uc001kcu.2	+	3	243	c.189C>A	c.(187-189)TGC>TGA	p.C63*		NM_207373	NP_997256	Q6UWK7	CJ099_HUMAN	hypothetical protein LOC387695 precursor	63						extracellular region				pancreas(1)	1						GTAAACCATGCAAGCTTGAGC	0.577													24	58					1.77063e-15	3.85176e-15	1	0	A	85944465	A	A	85944465	4	1	166	1	0	0	0	0	0	1	0	0	1634	718	25	4	199	4	C10orf99	10	85944465	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1199234	85944465	49590282	609	30937											
FAS	355	broad.mit.edu	37	chr10	90762893	90762893	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgttactacagttgagacTcagaacttggaaggcctgca	12	10	10	9	0	1	2	1	1	0	2	1	4	1	3	1	2	4	3	1	2	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:90762893T>A	uc001kfr.2	+	2	484	c.138T>A	c.(136-138)ACT>ACA	p.T46T	FAS_uc010qna.1_RNA|FAS_uc001kfs.2_Silent_p.T46T|FAS_uc001kft.2_Silent_p.T46T|FAS_uc010qnb.1_RNA|FAS_uc010qnc.1_RNA|FAS_uc001kfw.2_Silent_p.T46T|FAS_uc010qnd.1_RNA|FAS_uc010qne.1_RNA|FAS_uc009xtp.2_RNA	NM_000043	NP_000034	P25445	TNR6_HUMAN	tumor necrosis factor receptor superfamily,	46	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			upper_aerodigestive_tract(1)|breast(1)	2		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		CAGTTGAGACTCAGAACTTGG	0.443									Autoimmune_Lymphoproliferative_syndrome_type_I				27	64					0	0	0	0	A	90762893	A	A	90762893	2	1	166	1	0	0	0	0	0	0	0	1	5713	1538	54	5		5	FAS	10	90762893	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	4818428	90762893	44771854	610	30938											
TNKS2	80351	broad.mit.edu	37	chr10	93601155	93601155	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatggaaatttacacctttaCatgaagcagcagcaaaagga	17	9	8	7	0	0	1	0	1	0	0	0	3	0	3	1	2	5	3	1	2	7	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:93601155C>A	uc001khp.2	+	15	2086	c.1789C>A	c.(1789-1791)CAT>AAT	p.H597N		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	597	ANK 12.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				TACACCTTTACATGAAGCAGC	0.323													17	57					2.94398e-08	5.45388e-08	1	0	A	93601155	A	A	93601155	3	1	166	1	0	0	0	0	1	0	0	0	16387	478	17	4	1847	4	TNKS2	10	93601155	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2838262	93601155	41933592	611	30939											
CYP2C19	1557	broad.mit.edu	37	chr10	96535277	96535277	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagcccgctgccttgtggaGgagttgagaaaaaccaaggg	12	6	15	8	1	0	1	0	1	0	1	0	5	0	3	3	3	3	2	3	3	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:96535277G>C	uc010qnz.1	+	3	462	c.462G>C	c.(460-462)GAG>GAC	p.E154D	CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Missense_Mutation_p.E132D	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	154					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GCCTTGTGGAGGAGTTGAGAA	0.517													39	121					0	0	0	0	C	96535277	C	C	96535277	3	2	166	1	0	0	0	0	1	0	0	0	4183	991	35	4	472	4	CYP2C19	10	96535277	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2934122	96535277	38999470	612	30940											
ABCC2	1244	broad.mit.edu	37	chr10	101544522	101544522	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatcctctaccaccaaacTctatcttgctaagcaggtaa	13	10	6	12	0	3	1	0	0	3	1	4	2	4	1	3	1	4	3	3	1	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:101544522T>A	uc001kqf.2	+	2	330	c.191T>A	c.(190-192)CTC>CAC	p.L64H		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	64	Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ACCACCAAACTCTATCTTGCT	0.473													28	55					0	0	0	0	A	101544522	A	A	101544522	3	1	166	1	0	0	0	0	1	0	0	0	53	1551	54	5	197	5	ABCC2	10	101544522	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5009245	101544522	33990225	613	30941											
ELOVL3	83401	broad.mit.edu	37	chr10	103988898	103988898	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatgccacaccacgatggaAcacttattctggtccttcat	10	11	8	12	1	2	0	1	0	1	0	3	3	3	2	3	3	2	0	3	3	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:103988898A>G	uc001kut.2	+	4	865	c.702A>G	c.(700-702)GAA>GAG	p.E234E		NM_152310	NP_689523	Q9HB03	ELOV3_HUMAN	elongation of very long chain fatty acids like	234					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			ovary(2)	2		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		CCACGATGGAACACTTATTCT	0.498													15	37					0	0	0	0	G	103988898	G	G	103988898	2	3	166	1	0	0	0	0	0	0	0	1	5099	40	2	5		5	ELOVL3	10	103988898	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2444376	103988898	31545849	614	30942											
PDCD4	27250	broad.mit.edu	37	chr10	112647635	112647635	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagcactggatactcctagAgcaccacaggtttgtatgat	11	12	9	9	0	0	2	0	1	0	1	1	3	1	3	2	2	3	4	2	2	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:112647635A>T	uc001kzh.2	+	6	1011	c.768A>T	c.(766-768)AGA>AGT	p.R256S	PDCD4_uc001kzg.2_Missense_Mutation_p.R245S|PDCD4_uc010qre.1_Missense_Mutation_p.R242S	NM_014456	NP_055271	Q53EL6	PDCD4_HUMAN	programmed cell death 4 isoform 1	256	MI 1.				apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		ATACTCCTAGAGCACCACAGG	0.353													14	28					0	0	0	0	T	112647635	T	T	112647635	3	4	166	1	0	0	0	0	1	0	0	0	11675	301	11	5	800	5	PDCD4	10	112647635	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	8658737	112647635	22887112	615	30943											
DCLRE1A	9937	broad.mit.edu	37	chr10	115608754	115608754	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttaccaggtattttcttatAgaatggacatgtcttttttc	9	19	6	7	0	2	1	0	0	2	1	3	2	2	2	1	2	1	1	1	2	5	9			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:115608754A>G	uc001law.2	-	2	3028	c.2110T>C	c.(2110-2112)TAT>CAT	p.Y704H		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	704					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		ATTTTCTTATAGAATGGACAT	0.378								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					67	136					0	0	0	0	G	115608754	G	G	115608754	3	3	166	1	0	0	0	0	1	0	0	0	4311	420	15	5	1044	5	DCLRE1A	10	115608754	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2961119	115608754	19925993	616	30944											
NHLRC2	374354	broad.mit.edu	37	chr10	115636695	115636695	+	Frame_Shift_Del	DEL	G	-	-																															actggacatcatagaattttGgtcgtttggaagaatggaca																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:115636695delG	uc001lax.1	+	3	959	c.747delG	c.(745-747)TTGfs	p.L249fs		NM_198514	NP_940916	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	249	NHL 1.				cell redox homeostasis					ovary(1)	1				Epithelial(162;0.017)|all cancers(201;0.0187)		ATAGAATTTTGGTCGTTTGGA	0.358													---	---	---								-	115636695	-	-	115636695	7	5	166	1	0	1	0	1	0	0	0	0	10460	1339	47	0	757	0	NHLRC2	10	115636695	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	27941	115636695	19898052	617	30945											
ATRNL1	26033	broad.mit.edu	37	chr10	117075142	117075142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgcattgaaggttcttcacGgggaccaatgaagcttattg	10	13	11	7	1	2	2	1	2	1	0	2	3	2	3	1	3	2	3	1	3	4	6	rs140980345		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:117075142G>A	uc001lcg.2	+	18	3319	c.2933G>A	c.(2932-2934)CGG>CAG	p.R978Q	ATRNL1_uc010qsm.1_Missense_Mutation_p.R153Q|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	978	PSI 5.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GGTTCTTCACGGGGACCAATG	0.458													27	67					0	0	0	0	A	117075142	A	A	117075142	3	1	166	1	0	0	0	0	1	0	0	0	1209	1116	39	1	3003	1	ATRNL1	10	117075142	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1438447	117075142	18459605	618	30946											
KCNK18	338567	broad.mit.edu	37	chr10	118957144	118957144	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgccattgaggacggccagGtcctggtggcagcagatgat	8	8	15	10	1	0	3	0	2	0	1	1	4	1	4	3	5	2	2	3	5	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:118957144G>T	uc010qsr.1	+	1	145	c.145G>T	c.(145-147)GTC>TTC	p.V49F		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	49						integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		GGACGGCCAGGTCCTGGTGGC	0.572													16	49					3.45872e-05	5.87952e-05	1	0	T	118957144	T	T	118957144	3	4	166	1	0	0	0	0	1	0	0	0	8104	1261	44	4	147	4	KCNK18	10	118957144	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1882002	118957144	16577603	619	30947											
HTRA1	5654	broad.mit.edu	37	chr10	124266322	124266322	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtcaccaccgggatcgtgaGcaccacccagcgaggcggca	10	3	13	15	4	1	1	1	1	0	0	2	3	1	2	4	3	2	2	4	3	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124266322G>T	uc001lgj.2	+	4	1021	c.893G>T	c.(892-894)AGC>ATC	p.S298I		NM_002775	NP_002766	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1 precursor	298	Serine protease.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				GGGATCGTGAGCACCACCCAG	0.622													25	75					8.24728e-16	1.81422e-15	1	0	T	124266322	T	T	124266322	3	4	166	1	0	0	0	0	1	0	0	0	7492	971	34	4	907	4	HTRA1	10	124266322	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5309178	124266322	11268425	620	30948											
DMBT1	1755	broad.mit.edu	37	chr10	124339216	124339216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actactgggacaccaatgatGccaatgtggtctgcaggcag	11	8	12	10	0	1	1	0	1	1	0	1	2	1	2	2	3	3	2	2	3	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124339216G>A	uc001lgk.1	+	10	908	c.802G>A	c.(802-804)GCC>ACC	p.A268T	DMBT1_uc001lgl.1_Missense_Mutation_p.A268T|DMBT1_uc001lgm.1_Missense_Mutation_p.A268T|DMBT1_uc009xzz.1_Missense_Mutation_p.A268T|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Missense_Mutation_p.A120T	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	268	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CACCAATGATGCCAATGTGGT	0.607													139	346					0	0	0	0	A	124339216	A	A	124339216	3	1	166	1	0	0	0	0	1	0	0	0	4599	1319	46	4	840	4	DMBT1	10	124339216	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	72894	124339216	11195531	621	30949											
C10orf120	399814	broad.mit.edu	37	chr10	124457725	124457725	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtaaaggctgatgatttcCcagagcccgagcaagcctca	11	7	12	11	1	1	3	1	2	0	1	2	4	2	3	3	2	3	3	3	2	3	2	rs148798284		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124457725C>T	uc001lgn.2	-	3	564	c.532G>A	c.(532-534)GGA>AGA	p.G178R		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	178										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				TGATGATTTCCCAGAGCCCGA	0.502													35	85					0	0	0	0	T	124457725	T	T	124457725	3	4	166	1	0	0	0	0	1	0	0	0	1596	632	22	4	479	4	C10orf120	10	124457725	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	118509	124457725	11077022	622	30950											
C10orf88	80007	broad.mit.edu	37	chr10	124708266	124708266	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaccttgtcaaggtctatccTtgatcctagagcaggagagc	10	10	11	10	0	2	3	1	1	1	2	4	5	4	3	3	2	2	1	3	2	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124708266T>A	uc001lgw.2	-	4	772	c.547A>T	c.(547-549)AGG>TGG	p.R183W	C10orf88_uc001lgx.2_Missense_Mutation_p.R85W	NM_024942	NP_079218	Q9H8K7	CJ088_HUMAN	hypothetical protein LOC80007	183											0		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		AGGTCTATCCTTGATCCTAGA	0.458													28	33					0	0	0	0	A	124708266	A	A	124708266	3	1	166	1	0	0	0	0	1	0	0	0	1628	1608	56	5	802	5	C10orf88	10	124708266	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	250541	124708266	10826481	623	30951											
DOCK1	1793	broad.mit.edu	37	chr10	129224216	129224216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggccgttccacgagaggatgGaggcctgtttcaaacagctg	9	8	14	10	2	1	1	1	0	0	1	2	4	2	3	3	4	2	3	3	4	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:129224216G>A	uc001ljt.2	+	47	4856	c.4792G>A	c.(4792-4794)GAG>AAG	p.E1598K	DOCK1_uc010qun.1_Missense_Mutation_p.E1619K|DOCK1_uc009yaq.2_Missense_Mutation_p.E593K	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1598	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CGAGAGGATGGAGGCCTGTTT	0.507													71	152					0	0	0	0	A	129224216	A	A	129224216	3	1	166	1	0	0	0	0	1	0	0	0	4706	1175	41	2	4978	2	DOCK1	10	129224216	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4515950	129224216	6310531	624	30952											
PHRF1	57661	broad.mit.edu	37	chr11	608998	608998	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacaggcggcctcggtcccGtgagaagtggccgcagaccc	7	4	15	15	4	0	2	0	1	0	2	2	3	1	2	4	4	0	2	4	4	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:608998G>T	uc001lqe.2	+	14	3673	c.3542G>T	c.(3541-3543)CGT>CTT	p.R1181L	PHRF1_uc010qwc.1_Missense_Mutation_p.R1180L|PHRF1_uc010qwd.1_Missense_Mutation_p.R1179L|PHRF1_uc010qwe.1_Missense_Mutation_p.R1177L|PHRF1_uc009ybz.1_Missense_Mutation_p.R971L|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1181	Arg-rich.						RNA polymerase binding|zinc ion binding				0						CCTCGGTCCCGTGAGAAGTGG	0.706													4	13					0.00024832	0.000412114	1	0	T	608998	T	T	608998	3	4	166	1	0	0	0	0	1	0	0	0	11916	1145	40	3	3589	3	PHRF1	11	608998	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08		608998	134397518	625	30953											
MUC6	4588	broad.mit.edu	37	chr11	1017714	1017714	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtgtggaggaagtgtgtGaatgtagggatgtagaggtt	9	12	20	0	0	0	2	0	1	0	1	0	5	0	5	0	5	0	3	0	5	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:1017714G>T	uc001lsw.2	-	31	5138	c.5087C>A	c.(5086-5088)TCA>TAA	p.S1696*		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1696	Thr-rich.|1; truncated.|Approximate repeats.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGAAGTGTGTGAATGTAGGGA	0.557													61	736					3.84483e-29	9.50299e-29	1	0	T	1017714	T	T	1017714	4	4	166	1	0	0	0	0	0	1	0	0	10033	1294	45	2	2244	2	MUC6	11	1017714	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	408716	1017714	133988802	626	30954											
TSPAN32	10077	broad.mit.edu	37	chr11	2335755	2335755	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtctcctttcagccgtctggGgagcacagaggctgacctgt	6	10	13	12	1	3	2	1	1	2	1	4	3	3	3	3	3	2	2	3	3	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:2335755G>C	uc001lvy.1	+	6	634	c.497G>C	c.(496-498)GGG>GCG	p.G166A	TSPAN32_uc001lvx.1_Silent_p.G209G|TSPAN32_uc009ydk.1_Missense_Mutation_p.G176A|TSPAN32_uc010qxk.1_Missense_Mutation_p.G201A|TSPAN32_uc009ydl.1_RNA|TSPAN32_uc001lvz.1_Missense_Mutation_p.G136A|TSPAN32_uc001lwb.1_Missense_Mutation_p.G136A|TSPAN32_uc001lwc.1_Missense_Mutation_p.G111A|TSPAN32_uc001lwd.1_5'Flank	NM_139022	NP_620591	Q96QS1	TSN32_HUMAN	tumor-suppressing subtransferable candidate 6	166					cell-cell signaling	integral to membrane				central_nervous_system(1)	1		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		AGCCGTCTGGGGAGCACAGAG	0.647													3	10					0	0	0	0	C	2335755	C	C	2335755	3	2	166	1	0	0	0	0	1	0	0	0	16714	1232	43	4	519	4	TSPAN32	11	2335755	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1318041	2335755	132670761	627	30955											
ART1	417	broad.mit.edu	37	chr11	3681167	3681167	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccgtgcgtgaggcgggcCgctcccgggcccactacctc	4	5	14	18	5	0	1	0	1	0	0	2	1	1	1	5	3	3	1	5	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:3681167C>A	uc001lye.1	+	3	519	c.418C>A	c.(418-420)CGC>AGC	p.R140S	ART1_uc009yeb.1_Missense_Mutation_p.R140S	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	140					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	TGAGGCGGGCCGCTCCCGGGC	0.667													24	40					2.39556e-15	5.17104e-15	1	0	A	3681167	A	A	3681167	3	1	166	1	0	0	0	0	1	0	0	0	999	652	23	3	424	3	ART1	11	3681167	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1345412	3681167	131325349	628	30956											
OR52I2	143502	broad.mit.edu	37	chr11	4608507	4608507	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttttgaccgctatgtagcCatctgcaagcctctacacta	9	12	7	13	1	2	1	0	1	2	0	2	1	2	1	3	0	4	4	3	0	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:4608507C>T	uc010qyh.1	+	1	465	c.465C>T	c.(463-465)GCC>GCT	p.A155A		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	155	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTATGTAGCCATCTGCAAGC	0.488													7	76					0	0	0	0	T	4608507	T	T	4608507	2	4	166	1	0	0	0	0	0	0	0	1	11175	581	21	4		4	OR52I2	11	4608507	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	927340	4608507	130398009	629	30957											
OR52I1	390037	broad.mit.edu	37	chr11	4615655	4615655	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttttgaccgctatgtagcCatctgcaagcctctacacta	9	12	7	13	1	2	1	0	1	2	0	2	1	2	1	3	0	4	4	3	0	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:4615655C>T	uc010qyi.1	+	1	387	c.387C>T	c.(385-387)GCC>GCT	p.A129A		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTATGTAGCCATCTGCAAGC	0.498													17	34					0	0	0	0	T	4615655	T	T	4615655	2	4	166	1	0	0	0	0	0	0	0	1	11174	581	21	4		4	OR52I1	11	4615655	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	7148	4615655	130390861	630	30958											
OR51V1	283111	broad.mit.edu	37	chr11	5221348	5221348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgtctgaacaggctaagcGgagaagatcctggtgcaggc	11	7	15	8	1	1	3	0	1	1	2	2	5	2	3	1	4	3	2	1	4	3	1	rs151191536		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:5221348G>A	uc010qyz.1	-	1	583	c.583C>T	c.(583-585)CGC>TGC	p.R195C		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGCTAAGCGGAGAAGATCC	0.398													11	39					0	0	0	0	A	5221348	A	A	5221348	3	1	166	1	0	0	0	0	1	0	0	0	11161	1116	39	1	385	1	OR51V1	11	5221348	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	605693	5221348	129785168	631	30959											
OR51Q1	390061	broad.mit.edu	37	chr11	5443437	5443437	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacattcatcagtcatgtccCaggtgactaacaccacacaa	14	8	5	14	0	3	1	3	1	0	0	4	1	4	1	2	1	1	0	2	1	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:5443437C>A	uc010qzd.1	+	1	7	c.7C>A	c.(7-9)CAG>AAG	p.Q3K	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGTCATGTCCCAGGTGACTAA	0.448													36	77					7.11191e-15	1.52676e-14	1	0	A	5443437	A	A	5443437	3	1	166	1	0	0	0	0	1	0	0	0	11158	595	21	4	9	4	OR51Q1	11	5443437	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	222089	5443437	129563079	632	30960											
OR56B1	387748	broad.mit.edu	37	chr11	5758078	5758078	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgagtgctttgctcagatttAtgccattcacttctttgtgg	6	18	9	8	0	3	2	2	1	1	1	3	2	3	2	1	1	3	2	1	1	1	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:5758078A>G	uc001mbt.1	+	1	332	c.332A>G	c.(331-333)TAT>TGT	p.Y111C	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|OR56B1_uc001mbs.1_Missense_Mutation_p.Y111C|OR56B1_uc009yev.1_Missense_Mutation_p.Y111C	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GCTCAGATTTATGCCATTCAC	0.458													9	32					0	0	0	0	G	5758078	G	G	5758078	3	3	166	1	0	0	0	0	1	0	0	0	11191	449	16	5	334	5	OR56B1	11	5758078	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	314641	5758078	129248438	633	30961											
OR52B2	255725	broad.mit.edu	37	chr11	6191434	6191434	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcaggatgctgtttcccagGactgcagtgatgtaaatgag	11	11	12	7	0	1	2	1	2	0	0	2	4	2	4	1	2	2	4	1	2	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:6191434G>T	uc010qzy.1	-	1	123	c.123C>A	c.(121-123)GTC>GTA	p.V41V		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTTTCCCAGGACTGCAGTGA	0.478													22	71					7.45023e-12	1.48853e-11	1	0	T	6191434	T	T	6191434	2	4	166	1	0	0	0	0	0	0	0	1	11165	1161	41	2		2	OR52B2	11	6191434	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	433356	6191434	128815082	634	30962											
SPTY2D1	144108	broad.mit.edu	37	chr11	18637522	18637522	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctttgacttttcctcaataGgaatcccattgtaaccatgg	10	15	6	10	0	2	1	1	1	1	0	4	2	4	2	3	2	1	1	3	2	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:18637522G>T	uc001moy.2	-	3	515	c.299C>A	c.(298-300)CCT>CAT	p.P100H	SPTY2D1_uc010rdi.1_Missense_Mutation_p.P100H	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	100										breast(1)	1						TTCCTCAATAGGAATCCCATT	0.433													54	87					1.0331e-37	2.60266e-37	1	0	T	18637522	T	T	18637522	3	4	166	1	0	0	0	0	1	0	0	0	15192	1000	35	4	1774	4	SPTY2D1	11	18637522	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	12446088	18637522	116368994	635	30963											
NAV2	89797	broad.mit.edu	37	chr11	20065574	20065574	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaggaattccctgtggtcTggtgatgatgtcaagaaatc	11	11	13	6	0	2	4	1	2	1	2	4	6	3	5	1	3	0	0	1	3	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:20065574T>C	uc010rdm.1	+	14	3385	c.3024T>C	c.(3022-3024)TCT>TCC	p.S1008S	NAV2_uc001mpp.2_Silent_p.S921S|NAV2_uc001mpr.3_Silent_p.S985S|NAV2_uc001mpt.2_Silent_p.S71S|NAV2_uc009yhx.2_Silent_p.S71S|NAV2_uc009yhy.1_5'UTR	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1008						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						CCCTGTGGTCTGGTGATGATG	0.527													24	64					0	0	0	0	C	20065574	C	C	20065574	2	2	166	1	0	0	0	0	0	0	0	1	10237	1567	55	5		5	NAV2	11	20065574	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1428052	20065574	114940942	636	30964											
NAV2	89797	broad.mit.edu	37	chr11	20066745	20066746	+	Missense_Mutation	DNP	GC	TT	TT																															cagcggggtgactgtcaccaGcaggtcagccacactgggca																								rs140697093	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:20066745_20066746GC>TT	uc010rdm.1	+	15	3861_3862	c.3500_3501GC>TT	c.(3499-3501)AGC>ATT	p.S1167I	NAV2_uc001mpp.2_Missense_Mutation_p.S1080I|NAV2_uc001mpr.3_Missense_Mutation_p.S1144I|NAV2_uc001mpt.2_Missense_Mutation_p.S230I|NAV2_uc009yhx.2_Missense_Mutation_p.S230I|NAV2_uc009yhy.1_Missense_Mutation_p.S143I	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1167						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						ACTGTCACCAGCAGGTCAGCCA	0.574													19	79					0	0	0	0	TT	20066746	TT	TT	20066745	3	4	166	1	0	0	0	0	1	0	0	0	10237	971	34	4	3594	4	NAV2	11	20066745	Missense_Mutation	DNP	GC	TCGA-CR-7402-01A-11D-2012-08	1171	20066745	114939771	637	30965											
SLC6A5	9152	broad.mit.edu	37	chr11	20623176	20623176	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacggatggaatcacgtccGtgctcccgggcagcgtggcc	6	6	14	15	5	1	0	1	0	0	0	3	2	3	2	4	4	2	2	4	4	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:20623176G>T	uc001mqd.2	+	2	778	c.505G>T	c.(505-507)GTG>TTG	p.V169L	SLC6A5_uc009yic.2_5'UTR	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	169	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	AATCACGTCCGTGCTCCCGGG	0.652													12	31					6.40141e-05	0.00010779	1	0	T	20623176	T	T	20623176	3	4	166	1	0	0	0	0	1	0	0	0	14751	1145	40	3	511	3	SLC6A5	11	20623176	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	556431	20623176	114383340	638	30966											
SLC17A6	57084	broad.mit.edu	37	chr11	22364872	22364872	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggctacatcatcactcagaTtccgggaggctacatcgcgt	9	9	11	12	3	3	1	3	0	0	1	5	2	4	2	1	3	2	2	1	3	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:22364872T>G	uc001mqk.2	+	3	832	c.419T>G	c.(418-420)ATT>AGT	p.I140S		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	140	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						ATCACTCAGATTCCGGGAGGC	0.577													28	65					0	0	0	0	G	22364872	G	G	22364872	3	3	166	1	0	0	0	0	1	0	0	0	14486	1493	52	5	429	5	SLC17A6	11	22364872	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1741696	22364872	112641644	639	30967											
KCNA4	3739	broad.mit.edu	37	chr11	30033418	30033418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacaaagccctcgtcctcccGaaacttcaacagggcctcct	10	7	6	18	2	1	0	1	0	0	0	5	1	4	0	5	1	3	0	5	1	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:30033418G>A	uc001msk.2	-	2	1960	c.808C>T	c.(808-810)CGG>TGG	p.R270W		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	270						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCGTCCTCCCGAAACTTCAAC	0.512													22	59					0	0	0	0	A	30033418	A	A	30033418	3	1	166	1	0	0	0	0	1	0	0	0	8044	1057	37	1	1157	1	KCNA4	11	30033418	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	7668546	30033418	104973098	640	30968											
CKAP5	9793	broad.mit.edu	37	chr11	46822845	46822845	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caacatgacattggtgtcctTtccaacaacctacaaagggg	13	9	8	11	0	0	1	0	1	0	0	2	1	2	1	3	3	4	0	3	3	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:46822845T>C	uc001ndi.1	-	9	1098	c.988A>G	c.(988-990)AAG>GAG	p.K330E	CKAP5_uc009ylg.1_Missense_Mutation_p.K216E|CKAP5_uc001ndj.1_Missense_Mutation_p.K330E	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	330					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TTGGTGTCCTTTCCAACAACC	0.393													16	33					0	0	0	0	C	46822845	C	C	46822845	3	2	166	1	0	0	0	0	1	0	0	0	3460	1850	64	5	5254	5	CKAP5	11	46822845	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	16789427	46822845	88183671	641	30969											
OR4A16	81327	broad.mit.edu	37	chr11	55110887	55110887	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtcacttatggatgccataTattccactgccatgtcaccc	9	13	6	13	0	2	0	2	0	0	0	3	1	3	1	4	1	2	0	4	1	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55110887T>C	uc010rie.1	+	1	211	c.211T>C	c.(211-213)TAT>CAT	p.Y71H		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						GGATGCCATATATTCCACTGC	0.453													44	111					0	0	0	0	C	55110887	C	C	55110887	3	2	166	1	0	0	0	0	1	0	0	0	11095	1406	49	5	213	5	OR4A16	11	55110887	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	8288042	55110887	79895629	642	30970											
OR4C15	81309	broad.mit.edu	37	chr11	55322574	55322574	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttatctgcatcataaacttCtccttgttgcttgtctccta	7	19	4	11	0	4	0	1	0	3	0	6	0	4	0	2	0	3	3	2	0	4	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55322574C>T	uc010rig.1	+	1	792	c.792C>T	c.(790-792)TTC>TTT	p.F264F		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCATAAACTTCTCCTTGTTGC	0.483										HNSCC(20;0.049)			28	89					0	0	0	0	T	55322574	T	T	55322574	2	4	166	1	0	0	0	0	0	0	0	1	11102	912	32	2		2	OR4C15	11	55322574	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	211687	55322574	79683942	643	30971											
OR4S2	219431	broad.mit.edu	37	chr11	55419304	55419304	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaatgttttcttggaggctAaagggaaatagttggactta	13	13	12	3	0	1	0	0	0	1	0	1	4	1	3	0	4	0	3	0	4	6	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55419304A>G	uc001nhs.1	+	1	925	c.925A>G	c.(925-927)AAA>GAA	p.K309E		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				CTTGGAGGCTAAAGGGAAATA	0.249													49	119					0	0	0	0	G	55419304	G	G	55419304	3	3	166	1	0	0	0	0	1	0	0	0	11137	363	13	5	927	5	OR4S2	11	55419304	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	96730	55419304	79587212	644	30972											
OR4C6	219432	broad.mit.edu	37	chr11	55433323	55433323	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctccctgaagtcttacagCtctaaagggcggcacaaagc	11	8	10	12	1	2	1	0	1	2	0	3	1	3	1	1	2	4	3	1	2	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55433323C>A	uc001nht.3	+	3	946	c.681C>A	c.(679-681)AGC>AGA	p.S227R	OR4C6_uc010rik.1_Missense_Mutation_p.S227R	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						AGTCTTACAGCTCTAAAGGGC	0.498													37	99					4.11147e-13	8.41178e-13	1	0	A	55433323	A	A	55433323	3	1	166	1	0	0	0	0	1	0	0	0	11106	796	28	4	683	4	OR4C6	11	55433323	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	14019	55433323	79573193	645	30973											
OR4C6	219432	broad.mit.edu	37	chr11	55433552	55433552	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaaactctggatgaaatggGaggctttggctgggaaataa	14	9	14	4	0	1	2	0	1	1	1	1	5	1	5	0	5	1	2	0	5	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55433552G>T	uc001nht.3	+	3	1175	c.910G>T	c.(910-912)GAG>TAG	p.E304*	OR4C6_uc010rik.1_Nonsense_Mutation_p.E304*	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GATGAAATGGGAGGCTTTGGC	0.408													7	36					1.06961e-07	1.95381e-07	1	0	T	55433552	T	T	55433552	4	4	166	1	0	0	0	0	0	1	0	0	11106	1175	41	2	912	2	OR4C6	11	55433552	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	229	55433552	79572964	646	30974											
OR5D16	390144	broad.mit.edu	37	chr11	55606250	55606250	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtttctgacagagagaaataCgacatctgaggccacattca	14	9	9	9	1	3	4	1	2	2	2	3	6	3	4	1	1	1	1	1	1	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55606250C>A	uc010rio.1	+	1	23	c.23C>A	c.(22-24)ACG>AAG	p.T8K		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				GAGAGAAATACGACATCTGAG	0.413													22	42					1.36565e-18	3.13794e-18	1	0	A	55606250	A	A	55606250	3	1	166	1	0	0	0	0	1	0	0	0	11210	536	19	3	25	3	OR5D16	11	55606250	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	172698	55606250	79400266	647	30975											
OR5D16	390144	broad.mit.edu	37	chr11	55607036	55607036	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acccaactccaaaaactccaGgcacacagtcaaagtggcct	15	5	6	15	0	1	0	1	0	0	0	3	0	3	0	4	2	2	1	4	2	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55607036G>T	uc010rio.1	+	1	809	c.809G>T	c.(808-810)AGG>ATG	p.R270M		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				AAAAACTCCAGGCACACAGTC	0.493													21	67					3.62473e-10	7.02718e-10	1	0	T	55607036	T	T	55607036	3	4	166	1	0	0	0	0	1	0	0	0	11210	1000	35	4	811	4	OR5D16	11	55607036	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	786	55607036	79399480	648	30976											
SPRYD5	84767	broad.mit.edu	37	chr11	55653181	55653181	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagctctgaggagcaaataTgtgggatgcacagagagaca	14	8	13	6	0	1	3	0	1	1	2	1	6	1	5	0	2	3	3	0	2	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55653181T>C	uc010rip.1	+	2	369	c.277T>C	c.(277-279)TGT>CGT	p.C93R	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	93	B box-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GGAGCAAATATGTGGGATGCA	0.488													5	44					0	0	0	0	C	55653181	C	C	55653181	3	2	166	1	0	0	0	0	1	0	0	0	15177	1464	51	5	279	5	SPRYD5	11	55653181	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	46145	55653181	79353335	649	30977											
SPRYD5	84767	broad.mit.edu	37	chr11	55658953	55658953	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccccacttgtggtgcaatatGttccaagacctaccagcaca	11	9	7	14	0	0	1	0	0	0	1	1	1	1	1	5	1	3	3	5	1	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55658953G>T	uc010rip.1	+	7	1296	c.1204G>T	c.(1204-1206)GTT>TTT	p.V402F	SPRYD5_uc010riq.1_Missense_Mutation_p.V259F	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	402	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GGTGCAATATGTTCCAAGACC	0.458													23	65					2.44723e-14	5.18548e-14	1	0	T	55658953	T	T	55658953	3	4	166	1	0	0	0	0	1	0	0	0	15177	1377	48	4	1226	4	SPRYD5	11	55658953	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5772	55658953	79347563	650	30978											
OR8H3	390152	broad.mit.edu	37	chr11	55890065	55890065	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgtcatttattgacctcAgttactcaactgtcgtcaca	10	14	5	12	1	4	1	4	1	0	0	5	1	4	1	2	0	2	1	2	0	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55890065A>G	uc001nii.1	+	1	217	c.217A>G	c.(217-219)AGT>GGT	p.S73G		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TATTGACCTCAGTTACTCAAC	0.443													85	224					0	0	0	0	G	55890065	G	G	55890065	3	3	166	1	0	0	0	0	1	0	0	0	11293	188	7	5	219	5	OR8H3	11	55890065	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	231112	55890065	79116451	651	30979											
OR8H3	390152	broad.mit.edu	37	chr11	55890212	55890212	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tctcctcaatggcctatgatCgctatgcagcgatctgcagt	8	12	9	12	2	3	1	1	1	2	0	5	2	3	1	2	1	3	3	2	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55890212C>G	uc001nii.1	+	1	364	c.364C>G	c.(364-366)CGC>GGC	p.R122G		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					GGCCTATGATCGCTATGCAGC	0.463													56	159					0	0	0	0	G	55890212	G	G	55890212	3	3	166	1	0	0	0	0	1	0	0	0	11293	884	31	3	366	3	OR8H3	11	55890212	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	147	55890212	79116304	652	30980											
OR5J2	282775	broad.mit.edu	37	chr11	55944846	55944846	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgactgctgtgaccatattCtatggtaccttaatctttag	9	16	7	9	0	2	2	0	2	2	0	2	2	2	2	2	1	2	2	2	1	5	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55944846C>A	uc010rjb.1	+	1	753	c.753C>A	c.(751-753)TTC>TTA	p.F251L		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					TGACCATATTCTATGGTACCT	0.453													34	92					2.68265e-12	5.38178e-12	1	0	A	55944846	A	A	55944846	3	1	166	1	0	0	0	0	1	0	0	0	11219	912	32	2	755	2	OR5J2	11	55944846	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	54634	55944846	79061670	653	30981											
OR5T2	219464	broad.mit.edu	37	chr11	55999944	55999944	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcgatagagcccacaaagtAgaagagtagaagctggtttg	14	8	12	7	1	0	4	0	0	0	4	1	5	0	4	1	1	2	4	1	1	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55999944A>T	uc010rjc.1	-	1	718	c.718T>A	c.(718-720)TAC>AAC	p.Y240N		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	240	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CCCACAAAGTAGAAGAGTAGA	0.438													35	100					0	0	0	0	T	55999944	T	T	55999944	3	4	166	1	0	0	0	0	1	0	0	0	11236	420	15	5	360	5	OR5T2	11	55999944	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	55098	55999944	79006572	654	30982											
OR8K3	219473	broad.mit.edu	37	chr11	56085963	56085963	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggttgcaaacccctatgtacTtttttctcagacatctggct	8	15	7	11	0	2	1	1	0	2	1	3	1	2	1	2	2	3	4	2	2	3	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56085963T>C	uc010rjf.1	+	1	181	c.181T>C	c.(181-183)TTT>CTT	p.F61L		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					CCCTATGTACTTTTTTCTCAG	0.383													9	180					0	0	0	0	C	56085963	C	C	56085963	3	2	166	1	0	0	0	0	1	0	0	0	11298	1609	56	5	183	5	OR8K3	11	56085963	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	86019	56085963	78920553	655	30983											
OR8K1	390157	broad.mit.edu	37	chr11	56114379	56114379	+	Frame_Shift_Del	DEL	C	-	-																															tgttttataccctgttgattCctatgctgaatccgttgatc																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56114379delC	uc010rjg.1	+	1	865	c.865delC	c.(865-867)CCTfs	p.P289fs		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CCTGTTGATTCCTATGCTGAA	0.353										HNSCC(65;0.19)			---	---	---								-	56114379	-	-	56114379	7	5	166	1	0	1	0	1	0	0	0	0	11297	855	30	0	867	0	OR8K1	11	56114379	Frame_Shift_Del	DEL	C	TCGA-CR-7402-01A-11D-2012-08	28416	56114379	78892137	656	30984											
OR5R1	219479	broad.mit.edu	37	chr11	56185379	56185379	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggctagaaggaaacactcAgtgatcatgaaggtgagaaa	17	6	13	5	0	2	4	2	3	0	2	2	7	2	5	0	3	1	1	0	3	5	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56185379A>T	uc010rji.1	-	1	330	c.330T>A	c.(328-330)ACT>ACA	p.T110T		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GGAAACACTCAGTGATCATGA	0.453													15	37					0	0	0	0	T	56185379	T	T	56185379	2	4	166	1	0	0	0	0	0	0	0	1	11234	175	7	5		5	OR5R1	11	56185379	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	71000	56185379	78821137	657	30985											
OR5M3	219482	broad.mit.edu	37	chr11	56237806	56237807	+	Missense_Mutation	DNP	GG	TT	TT																															tgactgaggaaaaagtacatGgggttgttaagctgaggact																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56237806_56237807GG>TT	uc010rjk.1	-	1	167_168	c.167_168CC>AA	c.(166-168)CCC>CAA	p.P56Q		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	56	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AAAAGTACATGGGGTTGTTAAG	0.396													18	44					0	0	0	0	TT	56237807	TT	TT	56237806	3	4	166	1	0	0	0	0	1	0	0	0	11229	1335	47	4	757	4	OR5M3	11	56237806	Missense_Mutation	DNP	GG	TCGA-CR-7402-01A-11D-2012-08	52427	56237806	78768710	658	30986											
OR5M1	390168	broad.mit.edu	37	chr11	56380486	56380486	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagccacagaaggataagtGaaaggttagcagtgactgag	15	6	15	5	0	0	4	0	3	0	1	0	6	0	6	1	3	2	2	1	3	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56380486G>C	uc001nja.1	-	1	493	c.493C>G	c.(493-495)CAC>GAC	p.H165D		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AAGGATAAGTGAAAGGTTAGC	0.463													20	39					0	0	0	0	C	56380486	C	C	56380486	3	2	166	1	0	0	0	0	1	0	0	0	11226	1290	45	2	458	2	OR5M1	11	56380486	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	142680	56380486	78626030	659	30987											
OR6Q1	219952	broad.mit.edu	37	chr11	57799168	57799168	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctctacctgtgcagctcaCctgactgtggtgagcctctt	5	14	9	13	0	3	2	1	2	2	0	4	2	3	2	3	1	4	2	3	1	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:57799168C>A	uc010rjz.1	+	1	744	c.744C>A	c.(742-744)CAC>CAA	p.H248Q	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				GTGCAGCTCACCTGACTGTGG	0.512													52	139					2.14674e-31	5.34639e-31	1	0	A	57799168	A	A	57799168	3	1	166	1	0	0	0	0	1	0	0	0	11262	506	18	4	746	4	OR6Q1	11	57799168	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1418682	57799168	77207348	660	30988											
OR1S2	219958	broad.mit.edu	37	chr11	57970690	57970690	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agggcatcaaagggaagaaaTttttctattgatgagctttc	13	13	10	5	0	2	3	1	2	1	1	3	4	2	4	0	2	1	2	0	2	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:57970690T>C	uc010rkb.1	-	1	964	c.964A>G	c.(964-966)ATT>GTT	p.I322V		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	322	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				AGGGAAGAAATTTTTCTATTG	0.418													55	97					0	0	0	0	C	57970690	C	C	57970690	3	2	166	1	0	0	0	0	1	0	0	0	11027	1493	52	5	16	5	OR1S2	11	57970690	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	171522	57970690	77035826	661	30989											
GLYATL1	92292	broad.mit.edu	37	chr11	58714591	58714591	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaataactcccataagctgCtggccctatacaaatccttg	12	11	6	12	0	0	1	0	1	0	0	2	1	2	1	3	1	4	2	3	1	6	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:58714591C>A	uc001nnf.2	+	4	407	c.31C>A	c.(31-33)CTG>ATG	p.L11M	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Intron|GLYATL1_uc001nni.1_Missense_Mutation_p.L11M|GLYATL1_uc001nnj.1_Missense_Mutation_p.L11M			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	11						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	CCATAAGCTGCTGGCCCTATA	0.478													14	28					1.5842e-08	2.95436e-08	1	0	A	58714591	A	A	58714591	3	1	166	1	0	0	0	0	1	0	0	0	6517	812	28	4		4	GLYATL1	11	58714591	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	743901	58714591	76291925	662	30990											
OR4D9	390199	broad.mit.edu	37	chr11	59282896	59282896	+	Frame_Shift_Del	DEL	C	-	-																															tcccactccctttctgtggaCccaatgttcttgacactttc																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:59282896delC	uc010rkv.1	+	1	511	c.511delC	c.(511-513)CCCfs	p.P171fs		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTTCTGTGGACCCAATGTTCT	0.532													---	---	---								-	59282896	-	-	59282896	7	5	166	1	0	1	0	1	0	0	0	0	11113	507	18	0	513	0	OR4D9	11	59282896	Frame_Shift_Del	DEL	C	TCGA-CR-7402-01A-11D-2012-08	568305	59282896	75723620	663	30991											
MS4A3	932	broad.mit.edu	37	chr11	59829952	59829952	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctttcaggccatccagatCctgaatgcagcaatgattct	10	13	7	11	0	3	3	1	2	2	1	5	3	5	3	3	1	2	2	3	1	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:59829952C>A	uc001nom.2	+	3	296	c.168C>A	c.(166-168)ATC>ATA	p.I56I	MS4A3_uc001non.2_Intron|MS4A3_uc001noo.2_Intron	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	56	Helical; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				CCATCCAGATCCTGAATGCAG	0.423													30	80					1.30897e-18	3.01833e-18	1	0	A	59829952	A	A	59829952	2	1	166	1	0	0	0	0	0	0	0	1	9914	845	30	2		2	MS4A3	11	59829952	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	547056	59829952	75176564	664	30992											
AHNAK	79026	broad.mit.edu	37	chr11	62289778	62289778	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtccactttggggcccttGatgtcaacttcaggggcctt	6	13	11	11	0	2	1	2	1	0	0	3	1	3	1	3	4	1	0	3	4	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:62289778G>C	uc001ntl.2	-	5	12411	c.12111C>G	c.(12109-12111)ATC>ATG	p.I4037M	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4037					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGGCCCTTGATGTCAACTT	0.493													92	249					0	0	0	0	C	62289778	C	C	62289778	3	2	166	1	0	0	0	0	1	0	0	0	414	1280	45	2	5681	2	AHNAK	11	62289778	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2459826	62289778	72716738	665	30993											
AHNAK	79026	broad.mit.edu	37	chr11	62298691	62298691	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaacatctggcaaagacatCttaggagctctgaagtgcat	13	10	9	9	0	4	2	1	1	3	1	4	3	4	3	0	2	3	3	0	2	4	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:62298691C>G	uc001ntl.2	-	5	3498	c.3198G>C	c.(3196-3198)AAG>AAC	p.K1066N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1066					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GCAAAGACATCTTAGGAGCTC	0.443													23	106					0	0	0	0	G	62298691	G	G	62298691	3	3	166	1	0	0	0	0	1	0	0	0	414	912	32	2	14594	2	AHNAK	11	62298691	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8913	62298691	72707825	666	30994											
PLCB3	5331	broad.mit.edu	37	chr11	64022704	64022704	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgtgtatactggccccccAggtctggtctgaggagctat	6	10	12	13	1	2	1	0	1	2	0	2	2	2	2	4	4	2	2	4	4	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:64022704A>T	uc001nzb.2	+	5	388	c.388_splice	c.e5-2	p.V130_splice	PLCB3_uc009ypg.1_Splice_Site_p.V130_splice|PLCB3_uc009yph.1_Splice_Site_p.V63_splice|PLCB3_uc009ypi.2_Splice_Site_p.V130_splice	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3						intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CTGGCCCCCCAGGTCTGGTCT	0.627													8	10					0	0	0	0	T	64022704	T	T	64022704	5	4	166	1	0	0	0	0	0	0	1	0	12084	202	7	5	404	5	PLCB3	11	64022704	Splice_Site	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1724013	64022704	70983812	667	30995											
NRXN2	9379	broad.mit.edu	37	chr11	64390225	64390225	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccagagtggggcctcacCtgggtggtgctgtccctcag	5	8	15	13	0	2	1	2	0	0	1	3	1	3	1	4	4	2	1	4	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:64390225C>A	uc001oap.2	-	6	1546	c.1035G>T	c.(1033-1035)CAG>CAT	p.Q345H	NRXN2_uc001oar.2_Missense_Mutation_p.Q1391H|NRXN2_uc001oas.2_Missense_Mutation_p.Q1321H|NRXN2_uc001oao.2_Missense_Mutation_p.Q31H|NRXN2_uc001oaq.2_Missense_Mutation_p.Q1058H	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	345	Extracellular (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GGGGCCTCACCTGGGTGGTGC	0.488													13	62					0.00185496	0.00302976	1	0	A	64390225	A	A	64390225	3	1	166	1	0	0	0	0	1	0	0	0	10720	695	24	4	977	4	NRXN2	11	64390225	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	367521	64390225	70616291	668	30996											
CDC42EP2	10435	broad.mit.edu	37	chr11	65088571	65088571	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttccacctcctgccggggAccatggtggaggggcctgaa	7	7	15	12	1	0	1	0	1	0	0	2	3	2	3	6	6	1	1	6	6	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:65088571A>G	uc001odl.2	+	2	652	c.202A>G	c.(202-204)ACC>GCC	p.T68A		NM_006779	NP_006770	O14613	BORG1_HUMAN	Cdc42 effector protein 2	68					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity				0						CCTGCCGGGGACCATGGTGGA	0.647													24	54					0	0	0	0	G	65088571	G	G	65088571	3	3	166	1	0	0	0	0	1	0	0	0	3091	275	10	5	204	5	CDC42EP2	11	65088571	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	698346	65088571	69917945	669	30997											
PACS1	55690	broad.mit.edu	37	chr11	66003368	66003368	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctcctgtgtctcccaacaGccctgatgaagactcctatc	8	11	6	16	0	2	3	0	2	2	1	6	3	3	3	4	0	2	0	4	0	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:66003368G>A	uc001oha.1	+	19	2342	c.2208_splice	c.e19-1	p.F736_splice	PACS1_uc010rou.1_Splice_Site_p.F272_splice	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1						interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						TCTCCCAACAGCCCTGATGAA	0.532													37	115					0	0	0	0	A	66003368	A	A	66003368	5	1	166	1	0	0	0	0	0	0	1	0	11426	985	34	4	2281	4	PACS1	11	66003368	Splice_Site	SNP	G	TCGA-CR-7402-01A-11D-2012-08	914797	66003368	69003148	670	30998											
RBM14	10432	broad.mit.edu	37	chr11	66392979	66392979	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcctaccgcggccagccAggcaatgcctacgatggggc	7	5	13	16	3	0	0	0	0	0	0	1	1	1	0	6	4	4	1	6	4	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:66392979A>T	uc001oit.2	+	2	1771	c.1632A>T	c.(1630-1632)CCA>CCT	p.P544P	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	544	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						GCGGCCAGCCAGGCAATGCCT	0.657													20	46					0	0	0	0	T	66392979	T	T	66392979	2	4	166	1	0	0	0	0	0	0	0	1	13180	175	7	5		5	RBM14	11	66392979	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	389611	66392979	68613537	671	30999											
CORO1B	57175	broad.mit.edu	37	chr11	67206199	67206199	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagcagtggtggtggaggcGggggcccctaggtgggagga	6	5	23	7	1	0	0	0	0	0	0	0	3	0	3	2	9	1	2	2	9	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:67206199G>T	uc001olj.1	-	9	1323	c.1287C>A	c.(1285-1287)CCC>CCA	p.P429P	PTPRCAP_uc001oli.1_5'Flank|CORO1B_uc009yrs.1_RNA|CORO1B_uc001olk.1_Silent_p.P429P|CORO1B_uc009yrt.1_RNA|CORO1B_uc009yru.1_RNA|CORO1B_uc001oll.1_Silent_p.P429P	NM_020441	NP_065174	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	429					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			TGGTGGAGGCGGGGGCCCCTA	0.716													3	7					1.23904e-05	2.12841e-05	1	0	T	67206199	T	T	67206199	2	4	166	1	0	0	0	0	0	0	0	1	3769	1103	39	3		3	CORO1B	11	67206199	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	813220	67206199	67800317	672	31000											
CPT1A	1374	broad.mit.edu	37	chr11	68571469	68571469	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcctaagccacacctaccCtgttcacagtgtctttgaca	10	10	7	14	0	2	1	1	1	1	0	2	1	2	1	4	1	2	1	4	1	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:68571469C>A	uc001oog.3	-	5	724	c.554G>T	c.(553-555)AGG>ATG	p.R185M	CPT1A_uc001oof.3_Missense_Mutation_p.R185M|CPT1A_uc009ysj.2_Missense_Mutation_p.R185M	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	185	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CACACCTACCCTGTTCACAGT	0.512													21	44					3.8784e-16	8.56044e-16	1	0	A	68571469	A	A	68571469	3	1	166	1	0	0	0	0	1	0	0	0	3846	695	24	4	1867	4	CPT1A	11	68571469	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1365270	68571469	66435047	673	31001											
SLCO2B1	11309	broad.mit.edu	37	chr11	74911282	74911282	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actccaggttttctacaccaActgcagctgcgtggtggagg	8	10	12	11	1	1	0	0	0	1	0	2	1	2	1	2	4	5	3	2	4	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:74911282A>G	uc001owb.2	+	11	2000	c.1613A>G	c.(1612-1614)AAC>AGC	p.N538S	SLCO2B1_uc010rrq.1_Missense_Mutation_p.N283S|SLCO2B1_uc010rrr.1_Missense_Mutation_p.N394S|SLCO2B1_uc010rrs.1_Missense_Mutation_p.N422S|SLCO2B1_uc001owc.2_Missense_Mutation_p.N311S|SLCO2B1_uc001owd.2_Missense_Mutation_p.N516S	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	538	Extracellular (Potential).|Kazal-like.				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	TTCTACACCAACTGCAGCTGC	0.622													19	87					0	0	0	0	G	74911282	G	G	74911282	3	3	166	1	0	0	0	0	1	0	0	0	14791	43	2	5	1655	5	SLCO2B1	11	74911282	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	6339813	74911282	60095234	674	31002											
PCF11	51585	broad.mit.edu	37	chr11	82880066	82880066	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtttgagggacctcatggtCagcctgtgggtggacttaga	7	11	16	7	0	2	2	2	1	0	1	2	4	2	4	2	5	1	1	2	5	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:82880066C>T	uc001ozx.3	+	8	3034	c.2689C>T	c.(2689-2691)CAG>TAG	p.Q897*	PCF11_uc010rsu.1_Nonsense_Mutation_p.Q1028*	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	897	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ACCTCATGGTCAGCCTGTGGG	0.552													20	38					0	0	0	0	T	82880066	T	T	82880066	4	4	166	1	0	0	0	0	0	1	0	0	11627	827	29	2	2719	2	PCF11	11	82880066	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	7968784	82880066	52126450	675	31003											
CREBZF	58487	broad.mit.edu	37	chr11	85375697	85375697	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgggggagggcgcgcgcaCggccacgccgccgcggctcc	3	2	18	18	9	0	0	0	0	0	0	2	1	1	1	4	5	0	2	4	5	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:85375697C>A	uc001pas.2	-	1	486	c.223G>T	c.(223-225)GTG>TTG	p.V75L	CREBZF_uc010rtc.1_RNA|CREBZF_uc010rtd.1_RNA	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	75					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				GGCGCGCGCACGGCCACGCCG	0.706													38	76					2.05212e-20	4.81695e-20	1	0	A	85375697	A	A	85375697	3	1	166	1	0	0	0	0	1	0	0	0	3878	536	19	3	845	3	CREBZF	11	85375697	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2495631	85375697	49630819	676	31004											
SYTL2	54843	broad.mit.edu	37	chr11	85420476	85420476	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacatattcaattgcaaacTgaatatttcctttaacttcc	13	15	2	11	0	1	1	1	1	0	0	3	1	3	1	3	0	3	1	3	0	6	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:85420476T>A	uc010rth.1	-	12	2174	c.1898A>T	c.(1897-1899)CAG>CTG	p.Q633L	SYTL2_uc010rtg.1_Missense_Mutation_p.Q634L|SYTL2_uc010rti.1_Missense_Mutation_p.Q609L|SYTL2_uc010rtj.1_Missense_Mutation_p.Q601L|SYTL2_uc001pav.2_Missense_Mutation_p.Q75L|SYTL2_uc010rte.1_Missense_Mutation_p.Q35L|SYTL2_uc001pax.2_Missense_Mutation_p.Q75L|SYTL2_uc001paz.2_5'UTR|SYTL2_uc001pba.2_Missense_Mutation_p.Q18L|SYTL2_uc001pay.2_Missense_Mutation_p.Q64L|SYTL2_uc001paw.2_Missense_Mutation_p.Q35L|SYTL2_uc009yvj.2_RNA|SYTL2_uc001pbd.2_Missense_Mutation_p.Q931L|SYTL2_uc001pbb.2_Missense_Mutation_p.Q971L|SYTL2_uc001pbc.2_Missense_Mutation_p.Q955L|SYTL2_uc010rtf.1_Missense_Mutation_p.Q451L	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	633	C2 1.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		AATTGCAAACTGAATATTTCC	0.413													25	65					0	0	0	0	A	85420476	A	A	85420476	3	1	166	1	0	0	0	0	1	0	0	0	15549	1580	55	5	934	5	SYTL2	11	85420476	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	44779	85420476	49586040	677	31005											
UBTFL1	642623	broad.mit.edu	37	chr11	89819843	89819843	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctggtcaagtaaagagatGcaacatttgtcagtgaggga	13	10	12	6	0	2	2	2	1	0	1	3	4	3	3	1	2	2	2	1	2	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:89819843G>A	uc010rub.1	+	1	726	c.726G>A	c.(724-726)ATG>ATA	p.M242I		NM_001143975	NP_001137447	P0CB47	UBFL1_HUMAN	upstream binding transcription factor, RNA	242	HMG box 2.				multicellular organismal development	cytoplasm|nucleus	DNA binding				0						GTAAAGAGATGCAACATTTGT	0.483													50	101					0	0	0	0	A	89819843	A	A	89819843	3	1	166	1	0	0	0	0	1	0	0	0	16978	1319	46	4	728	4	UBTFL1	11	89819843	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4399367	89819843	45186673	678	31006											
FAT3	120114	broad.mit.edu	37	chr11	92531613	92531613	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaccggaatgctctgcttGtgtatcagattgtggagtca	9	12	12	8	1	3	1	2	0	1	1	3	3	3	3	1	2	3	4	1	2	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:92531613G>C	uc001pdj.3	+	9	5451	c.5434G>C	c.(5434-5436)GTG>CTG	p.V1812L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1812	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGCTCTGCTTGTGTATCAGAT	0.478										TCGA Ovarian(4;0.039)			10	23					0	0	0	0	C	92531613	C	C	92531613	3	2	166	1	0	0	0	0	1	0	0	0	5723	1377	48	4	5468	4	FAT3	11	92531613	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2711770	92531613	42474903	679	31007											
FAT3	120114	broad.mit.edu	37	chr11	92533403	92533403	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tatgtgagtgaattagccccCcggggccattttgtaacctg	8	12	11	10	1	0	2	0	2	0	0	0	2	0	2	5	2	2	1	5	2	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:92533403C>G	uc001pdj.3	+	9	7241	c.7224C>G	c.(7222-7224)CCC>CCG	p.P2408P		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2408	Cadherin 22.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AATTAGCCCCCCGGGGCCATT	0.443										TCGA Ovarian(4;0.039)			42	89					0	0	0	0	G	92533403	G	G	92533403	2	3	166	1	0	0	0	0	0	0	0	1	5723	610	22	4		4	FAT3	11	92533403	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1790	92533403	42473113	680	31008											
TRPC6	7225	broad.mit.edu	37	chr11	101344380	101344380	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttcttccaagtgatatctgCagaggtccaaagctttcatt	10	14	8	9	0	3	2	1	1	2	1	5	2	5	2	2	1	2	3	2	1	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:101344380C>G	uc001pgk.3	-	7	2294	c.1869G>C	c.(1867-1869)CTG>CTC	p.L623L	TRPC6_uc009ywy.2_Silent_p.L507L|TRPC6_uc009ywz.1_Silent_p.L568L	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	623	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GTGATATCTGCAGAGGTCCAA	0.348													17	60					0	0	0	0	G	101344380	G	G	101344380	2	3	166	1	0	0	0	0	0	0	0	1	16650	697	25	4		4	TRPC6	11	101344380	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8810977	101344380	33662136	681	31009											
KIAA1377	57562	broad.mit.edu	37	chr11	101834193	101834193	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctcctcaatctacatcaaaTattagaagtggtaaaaatat	17	12	4	8	0	3	1	2	0	1	1	4	1	4	1	2	1	1	1	2	1	10	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:101834193T>C	uc001pgm.2	+	6	2697	c.2427T>C	c.(2425-2427)AAT>AAC	p.N809N	KIAA1377_uc001pgn.2_Silent_p.N765N|KIAA1377_uc010run.1_Silent_p.N610N|KIAA1377_uc009yxa.1_Silent_p.N610N	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	809							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CTACATCAAATATTAGAAGTG	0.348													9	28					0	0	0	0	C	101834193	C	C	101834193	2	2	166	1	0	0	0	0	0	0	0	1	8266	1403	49	5		5	KIAA1377	11	101834193	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	489813	101834193	33172323	682	31010											
MMP20	9313	broad.mit.edu	37	chr11	102477375	102477375	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgatggggggcatggggcaGagtgggcttccccaggaata	8	7	19	7	0	0	2	0	1	0	1	1	3	1	3	2	7	0	3	2	7	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:102477375G>C	uc001phc.2	-	6	857	c.844C>G	c.(844-846)CTG>GTG	p.L282V		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	282					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GCATGGGGCAGAGTGGGCTTC	0.522													19	47					0	0	0	0	C	102477375	C	C	102477375	3	2	166	1	0	0	0	0	1	0	0	0	9712	933	33	2	627	2	MMP20	11	102477375	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	643182	102477375	32529141	683	31011											
DDI1	414301	broad.mit.edu	37	chr11	103908508	103908508	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttacagtgctctttctccAtacttgaggatcaacccatg	9	14	6	12	0	4	1	1	1	3	0	5	2	4	2	2	1	4	1	2	1	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:103908508A>G	uc001phr.2	+	1	1201	c.958A>G	c.(958-960)ATA>GTA	p.I320V	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	320					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CTCTTTCTCCATACTTGAGGA	0.453													32	60					0	0	0	0	G	103908508	G	G	103908508	3	3	166	1	0	0	0	0	1	0	0	0	4345	217	8	5	960	5	DDI1	11	103908508	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1431133	103908508	31098008	684	31012											
KBTBD3	143879	broad.mit.edu	37	chr11	105925058	105925058	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaacatttccacattatCatctgttatttttgtttttc	10	20	4	7	0	2	1	1	0	1	1	4	2	3	1	1	0	1	2	1	0	4	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:105925058C>A	uc001pja.2	-	4	998	c.358G>T	c.(358-360)GAT>TAT	p.D120Y	KBTBD3_uc001pjb.2_Missense_Mutation_p.D120Y|KBTBD3_uc009yxm.2_Missense_Mutation_p.D41Y	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	116										ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TCCACATTATCATCTGTTATT	0.328													8	25					0.00307968	0.00498857	1	0	A	105925058	A	A	105925058	3	1	166	1	0	0	0	0	1	0	0	0	8033	826	29	2	1484	2	KBTBD3	11	105925058	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2016550	105925058	29081458	685	31013											
CWF19L2	143884	broad.mit.edu	37	chr11	107224343	107224343	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgcagcaagactccgatgCtcagcaatagcttttttcct	9	13	8	11	1	1	1	1	0	0	1	3	2	3	1	2	0	5	5	2	0	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:107224343C>A	uc010rvp.1	-	13	2022	c.1992G>T	c.(1990-1992)GAG>GAT	p.E664D	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	664	Potential.						catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		GACTCCGATGCTCAGCAATAG	0.413													24	53					2.21704e-12	4.45681e-12	1	0	A	107224343	A	A	107224343	3	1	166	1	0	0	0	0	1	0	0	0	4089	796	28	4	716	4	CWF19L2	11	107224343	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1299285	107224343	27782173	686	31014											
ZBTB16	7704	broad.mit.edu	37	chr11	113934661	113934661	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atgaccataggacagtctctCctgcagggaactcttcagcc	10	9	9	13	0	3	1	1	1	2	0	5	3	4	3	3	2	3	1	3	2	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:113934661C>G	uc001pop.2	+	2	903	c.639C>G	c.(637-639)CTC>CTG	p.L213L	ZBTB16_uc001poo.1_Silent_p.L213L|ZBTB16_uc001poq.2_Silent_p.L213L	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	213					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		GACAGTCTCTCCTGCAGGGAA	0.597													15	33					0	0	0	0	G	113934661	G	G	113934661	2	3	166	1	0	0	0	0	0	0	0	1	17593	842	30	2		2	ZBTB16	11	113934661	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	6710318	113934661	21071855	687	31015											
FAM55A	120400	broad.mit.edu	37	chr11	114401134	114401134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgaaaataattttatcatagCcttggttccttgccctccag	10	15	6	10	0	1	1	1	1	0	0	3	1	3	1	4	1	2	1	4	1	5	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:114401134C>T	uc001ppa.2	-	3	587	c.170G>A	c.(169-171)GGC>GAC	p.G57D	FAM55A_uc010rxd.1_5'UTR|FAM55A_uc001ppb.1_Missense_Mutation_p.G199D	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	199						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		TTTATCATAGCCTTGGTTCCT	0.498													21	61					0	0	0	0	T	114401134	T	T	114401134	3	4	166	1	0	0	0	0	1	0	0	0	5616	739	26	4	1063	4	FAM55A	11	114401134	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	466473	114401134	20605382	688	31016											
CADM1	23705	broad.mit.edu	37	chr11	115080341	115080341	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggtggtggtggtggtggtgGtggttgttgtgggaggaggg	2	13	26	0	0	0	0	0	0	0	0	0	2	0	2	0	11	0	2	0	11	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:115080341G>T	uc001ppi.3	-	8	1160	c.1031C>A	c.(1030-1032)ACC>AAC	p.T344N	CADM1_uc001ppf.3_Intron|CADM1_uc001ppk.3_Intron|CADM1_uc001ppj.3_Intron|CADM1_uc001pph.3_Missense_Mutation_p.T96N	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	344	Extracellular (Potential).			PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		ggtggtggtggtggttgttgt	0.274													14	38					4.3838e-07	7.8828e-07	1	0	T	115080341	T	T	115080341	3	4	166	1	0	0	0	0	1	0	0	0	2578	1261	44	4	309	4	CADM1	11	115080341	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	679207	115080341	19926175	689	31017											
DSCAML1	57453	broad.mit.edu	37	chr11	117303127	117303127	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgctctggatgagggttGggtggtgcaaggagacgcca	7	9	18	7	1	1	2	0	1	1	1	1	4	1	3	1	5	2	3	1	5	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:117303127G>C	uc001prh.1	-	30	5302	c.5300C>G	c.(5299-5301)CCA>CGA	p.P1767R		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1707	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GATGAGGGTTGGGTGGTGCAA	0.577													14	35					0	0	0	0	C	117303127	C	C	117303127	3	2	166	1	0	0	0	0	1	0	0	0	4791	1348	47	4	1057	4	DSCAML1	11	117303127	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2222786	117303127	17703389	690	31018											
DSCAML1	57453	broad.mit.edu	37	chr11	117332289	117332289	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgatggacagggcccggaCgttctcagggggctggctgg	6	7	19	9	2	1	1	1	1	1	0	2	3	1	3	1	7	0	3	1	7	0	1	rs142275732		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:117332289C>A	uc001prh.1	-	18	3471	c.3469G>T	c.(3469-3471)GTC>TTC	p.V1157F		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1097	Fibronectin type-III 3.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGGCCCGGACGTTCTCAGGG	0.612													17	47					2.4624e-09	4.68573e-09	1	0	A	117332289	A	A	117332289	3	1	166	1	0	0	0	0	1	0	0	0	4791	536	19	3	2936	3	DSCAML1	11	117332289	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	29162	117332289	17674227	691	31019											
MLL	4297	broad.mit.edu	37	chr11	118347536	118347536	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagggtcaagaaagtgactCatcagagacctctgtgcgag	12	8	12	9	1	5	3	4	1	1	2	5	5	5	3	1	1	1	0	1	1	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:118347536C>A	uc001pta.2	+	4	3196	c.3173C>A	c.(3172-3174)TCA>TAA	p.S1058*	MLL_uc001ptb.2_Nonsense_Mutation_p.S1058*|MLL_uc001ptd.1_Nonsense_Mutation_p.S50*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1058					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GAAAGTGACTCATCAGAGACC	0.438			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								21	62					4.63292e-17	1.03305e-16	1	0	A	118347536	A	A	118347536	4	1	166	1	0	0	0	0	0	1	0	0	9673	838	29	2	3187	2	MLL	11	118347536	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1015247	118347536	16658980	692	31020											
THY1	7070	broad.mit.edu	37	chr11	119290994	119290994	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggctgaactcgtactggatgGgtgaactgctggtattctca	8	12	13	8	1	1	2	1	2	1	0	3	3	1	3	0	4	4	4	0	4	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:119290994G>T	uc001pwq.2	-	2	174	c.140C>A	c.(139-141)CCC>CAC	p.P47H	uc001pwo.2_Intron|uc001pwp.1_Intron|THY1_uc001pwr.2_Missense_Mutation_p.P47H|THY1_uc001pws.2_RNA	NM_006288	NP_006279	P04216	THY1_HUMAN	Thy-1 cell surface antigen preproprotein	47	Ig-like V-type.				angiogenesis|cell-cell adhesion|cytoskeleton organization|focal adhesion assembly|negative regulation of axonogenesis|negative regulation of cell migration|negative regulation of protein kinase activity|negative regulation of T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell activation|retinal cone cell development|T cell receptor signaling pathway	endoplasmic reticulum|growth cone|integral to plasma membrane|membrane raft	GPI anchor binding|integrin binding|Rho GTPase activator activity				0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.83e-05)		GTACTGGATGGGTGAACTGCT	0.587													38	96					1.49673e-21	3.55157e-21	1	0	T	119290994	T	T	119290994	3	4	166	1	0	0	0	0	1	0	0	0	15951	1232	43	4	353	4	THY1	11	119290994	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	943458	119290994	15715522	693	31021											
POU2F3	25833	broad.mit.edu	37	chr11	120180221	120180221	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagggtctggttctgcaacCgacgccaaaaggagaagcga	12	6	14	9	3	2	2	0	1	2	1	2	5	2	2	2	3	3	2	2	3	4	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:120180221C>A	uc001pxc.2	+	10	1096	c.994C>A	c.(994-996)CGA>AGA	p.R332R	POU2F3_uc010rzk.1_Silent_p.R286R|POU2F3_uc010rzl.1_Silent_p.R262R|POU2F3_uc001pxe.1_Silent_p.R117R	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	332	Homeobox.				negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding	p.R332*(1)		ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		GTTCTGCAACCGACGCCAAAA	0.557													19	41					1.33834e-09	2.56667e-09	1	0	A	120180221	A	A	120180221	2	1	166	1	0	0	0	0	0	0	0	1	12328	644	23	3		3	POU2F3	11	120180221	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	889227	120180221	14826295	694	31022											
TECTA	7007	broad.mit.edu	37	chr11	120998532	120998532	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccccgacacatgctccGacctgacggcctcgcggaac	7	5	11	18	5	0	1	0	1	0	0	2	4	1	2	5	2	3	2	5	2	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:120998532G>T	uc010rzo.1	+	8	1846	c.1846G>T	c.(1846-1848)GAC>TAC	p.D616Y		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	616	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CACATGCTCCGACCTGACGGC	0.642													26	70					1.5548e-18	3.5559e-18	1	0	T	120998532	T	T	120998532	3	4	166	1	0	0	0	0	1	0	0	0	15813	1058	37	3	1876	3	TECTA	11	120998532	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	818311	120998532	14007984	695	31023											
SORL1	6653	broad.mit.edu	37	chr11	121495940	121495940	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgcctttttggcaaccaGatctgtggggagcctgccat	8	11	12	10	0	1	2	0	0	1	2	1	3	1	3	4	3	4	1	4	3	1	2	rs149393026	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:121495940G>C	uc001pxx.2	+	46	6398	c.6318G>C	c.(6316-6318)CAG>CAC	p.Q2106H	SORL1_uc010rzp.1_Missense_Mutation_p.Q952H|SORL1_uc010rzq.1_Missense_Mutation_p.Q721H	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	2106	Extracellular (Potential).|Fibronectin type-III 6.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TTGGCAACCAGATCTGTGGGG	0.468													23	70					0	0	0	0	C	121495940	C	C	121495940	3	2	166	1	0	0	0	0	1	0	0	0	14998	933	33	2	6500	2	SORL1	11	121495940	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	497408	121495940	13510576	696	31024											
OR6X1	390260	broad.mit.edu	37	chr11	123624645	123624645	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttgctatgacgcccaggagTtccaaaatgctggtgtctat	9	12	11	9	1	1	1	0	1	1	0	2	2	2	2	2	2	2	4	2	2	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:123624645T>A	uc010rzy.1	-	1	582	c.582A>T	c.(580-582)GAA>GAT	p.E194D		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CGCCCAGGAGTTCCAAAATGC	0.438													28	70					0	0	0	0	A	123624645	A	A	123624645	3	1	166	1	0	0	0	0	1	0	0	0	11266	1722	60	5	358	5	OR6X1	11	123624645	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2128705	123624645	11381871	697	31025											
OR8B3	390271	broad.mit.edu	37	chr11	124266529	124266529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caatgacatgagagctacaaGtactgaaggcttttgatctt	13	12	9	7	0	1	4	0	4	1	1	1	5	1	4	0	1	3	3	0	1	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124266529G>A	uc010saj.1	-	1	719	c.719C>T	c.(718-720)ACT>ATT	p.T240I	OR8B2_uc001qab.3_Intron	NM_001005467	NP_001005467	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGAGCTACAAGTACTGAAGGC	0.383													24	92					0	0	0	0	A	124266529	A	A	124266529	3	1	166	1	0	0	0	0	1	0	0	0	11282	1029	36	4	224	4	OR8B3	11	124266529	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	641884	124266529	10739987	698	31026											
OR8B8	26493	broad.mit.edu	37	chr11	124310451	124310451	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggggaaggatgtcacacatGtagtggttgacaaggttatt	12	11	14	4	0	1	1	1	1	0	0	1	3	1	3	0	5	0	3	0	5	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124310451G>A	uc010sal.1	-	1	531	c.531C>T	c.(529-531)TAC>TAT	p.Y177Y		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TGTCACACATGTAGTGGTTGA	0.502													26	54					0	0	0	0	A	124310451	A	A	124310451	2	1	166	1	0	0	0	0	0	0	0	1	11284	1372	48	4		4	OR8B8	11	124310451	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	43922	124310451	10696065	699	31027											
ROBO4	54538	broad.mit.edu	37	chr11	124756439	124756439	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgccagggcccgggcaaaGtgagcatcagcgaggaagga	12	3	16	10	2	1	1	1	1	0	0	1	4	1	3	2	4	3	2	2	4	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124756439G>C	uc001qbg.2	-	16	2855	c.2715C>G	c.(2713-2715)CAC>CAG	p.H905Q	ROBO4_uc010sas.1_Missense_Mutation_p.H760Q|ROBO4_uc001qbh.2_3'UTR|ROBO4_uc001qbi.2_Missense_Mutation_p.H463Q	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	905					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CCCGGGCAAAGTGAGCATCAG	0.602													13	51					0	0	0	0	C	124756439	C	C	124756439	3	2	166	1	0	0	0	0	1	0	0	0	13581	1020	36	4	320	4	ROBO4	11	124756439	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	445988	124756439	10250077	700	31028											
ROBO4	54538	broad.mit.edu	37	chr11	124765699	124765699	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accttccagctgagccacacCgccggtctaggcttggggcc	6	7	12	16	2	1	1	0	1	1	0	2	1	2	1	6	4	2	2	6	4	1	3	rs143848676		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124765699C>G	uc001qbg.2	-	5	929	c.789G>C	c.(787-789)GCG>GCC	p.A263A	ROBO4_uc010sas.1_Silent_p.A118A|ROBO4_uc001qbh.2_Silent_p.A153A|ROBO4_uc001qbi.2_5'Flank|ROBO4_uc010sat.1_5'Flank	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	263	Fibronectin type-III 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		TGAGCCACACCGCCGGTCTAG	0.597													36	46					0	0	0	0	G	124765699	G	G	124765699	2	3	166	1	0	0	0	0	0	0	0	1	13581	639	23	3		3	ROBO4	11	124765699	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	9260	124765699	10240817	701	31029											
SNX19	399979	broad.mit.edu	37	chr11	130773227	130773227	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccatttccactgttctgtTagtagcaagaggagcagatc	11	11	10	9	0	1	2	0	0	1	2	3	3	2	3	2	1	3	5	2	1	3	4	rs138603150		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:130773227T>C	uc001qgk.3	-	8	3044	c.2496A>G	c.(2494-2496)CTA>CTG	p.L832L	SNX19_uc009zcw.2_Silent_p.L69L|SNX19_uc010sce.1_Silent_p.L212L|SNX19_uc010scf.1_Silent_p.L275L|SNX19_uc010scg.1_Silent_p.L69L	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	832					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		ACTGTTCTGTTAGTAGCAAGA	0.448													12	34					0	0	0	0	C	130773227	C	C	130773227	2	2	166	1	0	0	0	0	0	0	0	1	14954	1741	61	5		5	SNX19	11	130773227	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	6007528	130773227	4233289	702	31030											
IGSF9B	22997	broad.mit.edu	37	chr11	133794770	133794770	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgatcagatcctgcatgacGgccagaacccggaactcata	12	7	9	13	2	2	4	2	2	0	2	3	5	3	5	3	2	3	1	3	2	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:133794770G>T	uc001qgx.3	-	15	2295	c.2064C>A	c.(2062-2064)GCC>GCA	p.A688A	IGSF9B_uc001qgy.1_Silent_p.A530A	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	688	Fibronectin type-III 2.|Extracellular (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCTGCATGACGGCCAGAACCC	0.577													37	134					3.09479e-21	7.30817e-21	1	0	T	133794770	T	T	133794770	2	4	166	1	0	0	0	0	0	0	0	1	7645	1103	39	3		3	IGSF9B	11	133794770	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3021543	133794770	1211746	703	31031											
WNT5B	81029	broad.mit.edu	37	chr12	1755062	1755062	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggccgagttccgcaaggtcGgggaccggctgaaggagaag	9	5	18	9	4	0	2	0	1	0	1	2	5	1	3	3	6	0	3	3	6	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:1755062G>T	uc009zdq.2	+	5	966	c.724G>T	c.(724-726)GGG>TGG	p.G242W	WNT5B_uc001qjj.2_Missense_Mutation_p.G242W|WNT5B_uc001qjk.2_Missense_Mutation_p.G242W|WNT5B_uc001qjl.2_Missense_Mutation_p.G242W	NM_032642	NP_116031	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family,	242					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			CCGCAAGGTCGGGGACCGGCT	0.662													28	50					6.12954e-19	1.4184e-18	1	0	T	1755062	T	T	1755062	3	4	166	1	0	0	0	0	1	0	0	0	17460	1116	39	3	738	3	WNT5B	12	1755062	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08		1755062	132096833	704	31032											
CD163	9332	broad.mit.edu	37	chr12	7653975	7653975	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccattattacacaccgttcCccactcctcctggactttca	8	12	4	17	1	1	0	1	0	0	0	4	1	4	1	6	1	1	1	6	1	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:7653975C>G	uc001qsz.3	-	3	345	c.217G>C	c.(217-219)GGA>CGA	p.G73R	CD163_uc001qta.3_Missense_Mutation_p.G73R|CD163_uc009zfw.2_Missense_Mutation_p.G73R	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	73	SRCR 1.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CACACCGTTCCCCACTCCTCC	0.502													36	95					0	0	0	0	G	7653975	G	G	7653975	3	3	166	1	0	0	0	0	1	0	0	0	2982	632	22	4	3309	4	CD163	12	7653975	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5898913	7653975	126197920	705	31033											
RIMKLB	57494	broad.mit.edu	37	chr12	8866600	8866600	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gactttagggctgtggtgatGgatgaggtggtgctgacaat	8	12	17	4	0	0	3	0	3	0	0	0	5	0	4	0	5	1	2	0	5	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:8866600G>T	uc001quu.2	+	2	389	c.138G>T	c.(136-138)ATG>ATT	p.M46I	RIMKLB_uc009zgf.1_RNA|RIMKLB_uc001qux.2_Missense_Mutation_p.M46I|RIMKLB_uc010sgl.1_Missense_Mutation_p.M46I|RIMKLB_uc001quw.2_Missense_Mutation_p.M46I	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	46					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CTGTGGTGATGGATGAGGTGG	0.428													17	26					5.01169e-05	8.45346e-05	1	0	T	8866600	T	T	8866600	3	4	166	1	0	0	0	0	1	0	0	0	13431	1348	47	4	140	4	RIMKLB	12	8866600	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1212625	8866600	124985295	706	31034											
PRH1	5554	broad.mit.edu	37	chr12	11034876	11034876	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggaggtccttgtgggcggccCccttggggaggtggtccctg	2	9	19	11	1	0	0	0	0	0	0	2	2	2	2	4	8	0	0	4	8	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:11034876C>A	uc001qzc.2	-	8	1047	c.459G>T	c.(457-459)GGG>GGT	p.G153G	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_RNA|PRB4_uc001qzf.1_Intron	NM_006250	NP_006241	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1	153						extracellular space	protein binding				0				BRCA - Breast invasive adenocarcinoma(232;0.245)		GTGGGCGGCCCCCTTGGGGAG	0.587													32	107					4.75821e-42	1.20337e-41	1	0	A	11034876	A	A	11034876	2	1	166	1	0	0	0	0	0	0	0	1	12544	610	22	4		4	PRH1	12	11034876	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2168276	11034876	122817019	707	31035											
GUCY2C	2984	broad.mit.edu	37	chr12	14796620	14796620	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccatggacttctgtcttactGgagtgcagatatgacattcc	9	13	9	10	0	2	2	0	1	2	1	3	4	3	4	2	2	2	1	2	2	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:14796620G>T	uc001rcd.2	-	17	1955	c.1818C>A	c.(1816-1818)TCC>TCA	p.S606S		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	606	Cytoplasmic (Potential).|Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						CTGTCTTACTGGAGTGCAGAT	0.373													20	89					2.37509e-13	4.88989e-13	1	0	T	14796620	T	T	14796620	2	4	166	1	0	0	0	0	0	0	0	1	6935	1335	47	4		4	GUCY2C	12	14796620	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3761744	14796620	119055275	708	31036											
PIK3C2G	5288	broad.mit.edu	37	chr12	18435606	18435606	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaataaaaggagtggacaTgtgaacattgtggaaccatc	16	8	12	5	0	0	2	0	1	0	1	1	6	0	5	1	3	2	0	1	3	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:18435606T>C	uc001rdt.2	+	2	707	c.591T>C	c.(589-591)CAT>CAC	p.H197H	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Silent_p.H197H|PIK3C2G_uc010sic.1_5'UTR	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	197					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity	p.H197L(1)		lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GGAGTGGACATGTGAACATTG	0.383													48	130					0	0	0	0	C	18435606	C	C	18435606	2	2	166	1	0	0	0	0	0	0	0	1	11966	1461	51	5		5	PIK3C2G	12	18435606	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	3638986	18435606	115416289	709	31037											
SLCO1B1	10599	broad.mit.edu	37	chr12	21349914	21349914	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actcctactgattctcgatgGgttggagcttggtggcttaa	7	14	12	8	1	1	1	0	1	1	0	3	3	2	2	1	4	2	3	1	4	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:21349914G>A	uc001req.3	+	8	866	c.762G>A	c.(760-762)TGG>TGA	p.W254*		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	254	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	ATTCTCGATGGGTTGGAGCTT	0.358													40	96					0	0	0	0	A	21349914	A	A	21349914	4	1	166	1	0	0	0	0	0	1	0	0	14787	1241	43	4	788	4	SLCO1B1	12	21349914	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2914308	21349914	112501981	710	31038											
KIAA0528	9847	broad.mit.edu	37	chr12	22680700	22680700	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccatcctgagatgactgttgCagcttcactatacagtaaag	12	11	8	10	0	1	2	1	2	0	1	2	3	2	2	2	0	3	4	2	0	4	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:22680700C>A	uc001rfq.2	-	4	532	c.304G>T	c.(304-306)GCA>TCA	p.A102S	KIAA0528_uc010sir.1_5'UTR|KIAA0528_uc010sis.1_Missense_Mutation_p.A102S|KIAA0528_uc010sit.1_Missense_Mutation_p.A102S|KIAA0528_uc010siu.1_Missense_Mutation_p.A102S|KIAA0528_uc001rfr.2_Missense_Mutation_p.A102S|KIAA0528_uc009ziy.1_Missense_Mutation_p.A102S	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	102							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						ATGACTGTTGCAGCTTCACTA	0.323													23	67					2.79863e-10	5.44179e-10	1	0	A	22680700	A	A	22680700	3	1	166	1	0	0	0	0	1	0	0	0	8221	710	25	4	2786	4	KIAA0528	12	22680700	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1330786	22680700	111171195	711	31039											
OVCH1	341350	broad.mit.edu	37	chr12	29631793	29631793	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcactccactgcttgatcgTaaagatacatagtcatgatc	13	11	7	10	1	1	3	1	2	0	1	4	3	2	3	1	0	3	3	1	0	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:29631793T>C	uc001rix.1	-	9	1044	c.1044A>G	c.(1042-1044)TTA>TTG	p.L348L		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	348	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TGCTTGATCGTAAAGATACAT	0.303													8	25					0	0	0	0	C	29631793	C	C	29631793	2	2	166	1	0	0	0	0	0	0	0	1	11377	1635	57	5		5	OVCH1	12	29631793	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	6951093	29631793	104220102	712	31040											
LRRK2	120892	broad.mit.edu	37	chr12	40692113	40692113	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatttccttcttatttgttGaaaatgagttgtattgctaa	10	20	6	5	0	2	2	1	2	1	0	3	2	3	2	1	0	1	4	1	0	5	9			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:40692113G>C	uc001rmg.3	+	24	3286	c.3165G>C	c.(3163-3165)TTG>TTC	p.L1055F	LRRK2_uc001rmh.1_Missense_Mutation_p.L677F|LRRK2_uc009zjw.2_5'UTR	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1055	LRR 3.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTTATTTGTTGAAAATGAGTT	0.333													15	41					0	0	0	0	C	40692113	C	C	40692113	3	2	166	1	0	0	0	0	1	0	0	0	9083	1281	45	2	3259	2	LRRK2	12	40692113	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	11060320	40692113	93159782	713	31041											
DBX2	440097	broad.mit.edu	37	chr12	45429829	45429829	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagtggaggatgcagggcGccgacaggacccaccgcagc	10	2	16	13	3	0	0	0	0	0	0	0	4	0	3	3	4	3	3	3	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:45429829G>C	uc001rok.1	-	2	644	c.472C>G	c.(472-474)CGC>GGC	p.R158G		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	158						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		gatgcagggcgccgacaggac	0.109													6	13					0	0	0	0	C	45429829	C	C	45429829	3	2	166	1	0	0	0	0	1	0	0	0	4277	1087	38	3	559	3	DBX2	12	45429829	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4737716	45429829	88422066	714	31042											
MLL2	8085	broad.mit.edu	37	chr12	49438025	49438025	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actcaacacctccgcctgtgCagcaggcccctttttcgtgc	6	10	8	17	2	1	0	1	0	0	0	3	0	2	0	5	1	4	2	5	1	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:49438025C>A	uc001rta.3	-	21	5146	c.5146G>T	c.(5146-5148)GCA>TCA	p.A1716S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1716					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCCGCCTGTGCAGCAGGCCCC	0.617			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)	OREG0021780	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	24					7.48243e-07	1.3381e-06	1	0	A	49438025	A	A	49438025	3	1	166	1	0	0	0	0	1	0	0	0	9674	710	25	4	11603	4	MLL2	12	49438025	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4008196	49438025	84413870	715	31043											
MLL2	8085	broad.mit.edu	37	chr12	49447314	49447314	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagccagcacgtttgcgggCagtcagagcagtgtccaggc	8	6	14	13	2	1	1	1	0	0	1	2	1	2	1	3	2	4	4	3	2	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:49447314C>T	uc001rta.3	-	6	784	c.784G>A	c.(784-786)GCC>ACC	p.A262T		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	262	Cys-rich.|PHD-type 1.|RING-type 1; atypical.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CGTTTGCGGGCAGTCAGAGCA	0.582			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			5	11					0	0	0	0	T	49447314	T	T	49447314	3	4	166	1	0	0	0	0	1	0	0	0	9674	710	25	4	16025	4	MLL2	12	49447314	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	9289	49447314	84404581	716	31044											
NCKAP5L	57701	broad.mit.edu	37	chr12	50186272	50186272	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagttgtcggggtgggcacAtgagagggtccgaggagctg	7	7	19	8	2	0	1	0	1	0	1	2	4	1	2	2	5	1	3	2	5	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:50186272A>G	uc009zlk.2	-	12	3951	c.3749T>C	c.(3748-3750)ATG>ACG	p.M1250T	NCKAP5L_uc001rvc.3_Missense_Mutation_p.M454T|NCKAP5L_uc001rvb.2_Missense_Mutation_p.M843T	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	1246	Pro-rich.									central_nervous_system(1)	1						GGGTGGGCACATGAGAGGGTC	0.632													8	27					0	0	0	0	G	50186272	G	G	50186272	3	3	166	1	0	0	0	0	1	0	0	0	10278	217	8	5	263	5	NCKAP5L	12	50186272	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	738958	50186272	83665623	717	31045											
LARP4	113251	broad.mit.edu	37	chr12	50847384	50847384	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgtatataatcctcaccaaCagtactcggtctatagtatt	12	14	5	10	1	2	0	1	0	1	0	4	0	3	0	2	1	2	3	2	1	8	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:50847384C>G	uc001rwp.1	+	9	1090	c.946C>G	c.(946-948)CAG>GAG	p.Q316E	LARP4_uc001rwo.1_Missense_Mutation_p.Q322E|LARP4_uc001rwq.1_Intron|LARP4_uc001rwr.1_Missense_Mutation_p.Q316E|LARP4_uc001rws.1_Missense_Mutation_p.Q315E|LARP4_uc009zlr.1_Missense_Mutation_p.Q135E|LARP4_uc001rwt.1_Intron|LARP4_uc001rwm.2_Missense_Mutation_p.Q316E|LARP4_uc001rwn.2_Missense_Mutation_p.Q246E	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	316							nucleotide binding|RNA binding			ovary(1)	1						TCCTCACCAACAGTACTCGGT	0.393													27	81					0	0	0	0	G	50847384	G	G	50847384	3	3	166	1	0	0	0	0	1	0	0	0	8670	479	17	4	980	4	LARP4	12	50847384	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	661112	50847384	83004511	718	31046											
ATF1	466	broad.mit.edu	37	chr12	51213453	51213453	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtcgcagaaagaagaaagAatatgtgaaatgcctggaaa	19	7	11	4	1	0	5	0	1	0	4	1	6	0	6	1	1	1	1	1	1	7	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:51213453A>G	uc001rww.3	+	7	985	c.707A>G	c.(706-708)GAA>GGA	p.E236G	ATF1_uc010smu.1_Missense_Mutation_p.E101G	NM_005171	NP_005162	P18846	ATF1_HUMAN	activating transcription factor 1	236					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(323)|FUS/ATF1(4)	soft_tissue(321)|ovary(2)|NS(2)|bone(2)|skin(2)	329						AAGAAGAAAGAATATGTGAAA	0.308			T	EWSR1|FUS	malignant melanoma of soft parts |angiomatoid fibrous histiocytoma 								21	26					0	0	0	0	G	51213453	G	G	51213453	3	3	166	1	0	0	0	0	1	0	0	0	1081	246	9	5	729	5	ATF1	12	51213453	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	366069	51213453	82638442	719	31047											
KRT79	338785	broad.mit.edu	37	chr12	53227940	53227940	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctccgagacaccgtcacTgagctgaagctggtgcgggc	7	7	14	13	3	1	3	1	2	0	1	2	4	2	3	2	2	4	3	2	2	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:53227940T>C	uc001sbb.2	-	1	138	c.105A>G	c.(103-105)TCA>TCG	p.S35S		NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	35	Head.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						ACACCGTCACTGAGCTGAAGC	0.647													18	42					0	0	0	0	C	53227940	C	C	53227940	2	2	166	1	0	0	0	0	0	0	0	1	8531	1567	55	5		5	KRT79	12	53227940	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2014487	53227940	80623955	720	31048											
KRT78	196374	broad.mit.edu	37	chr12	53233651	53233651	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcacagcagccgggccaGgttctgcttggccatcctca	6	8	11	16	2	2	0	1	0	1	0	4	0	3	0	4	3	3	4	4	3	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:53233651G>T	uc001sbc.1	-	7	1229	c.1165C>A	c.(1165-1167)CTG>ATG	p.L389M		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	389	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						AGCCGGGCCAGGTTCTGCTTG	0.637													20	50					7.21436e-19	1.66551e-18	1	0	T	53233651	T	T	53233651	3	4	166	1	0	0	0	0	1	0	0	0	8530	991	35	4	409	4	KRT78	12	53233651	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5711	53233651	80618244	721	31049											
KRT18	3875	broad.mit.edu	37	chr12	53346565	53346565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccaaaagaccaccacccGccggatagtggatggcaaag	14	4	10	13	2	0	1	0	0	0	1	1	3	1	3	5	3	0	1	5	3	4	1	rs148580152		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:53346565G>A	uc001sbe.2	+	8	1301	c.1232G>A	c.(1231-1233)CGC>CAC	p.R411H	KRT18_uc009zmn.1_3'UTR|KRT18_uc001sbf.1_3'UTR|KRT18_uc001sbg.2_Missense_Mutation_p.R411H|KRT18_uc009zmo.2_3'UTR	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	411	Tail.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						ACCACCACCCGCCGGATAGTG	0.532													24	48					0	0	0	0	A	53346565	A	A	53346565	3	1	166	1	0	0	0	0	1	0	0	0	8494	1087	38	1	1258	1	KRT18	12	53346565	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	112914	53346565	80505330	722	31050											
IKZF4	64375	broad.mit.edu	37	chr12	56429106	56429106	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgtccggggggagcataaGgtgggctagcaacctctccc	8	8	14	11	1	1	0	0	0	1	0	3	1	2	1	3	5	3	3	3	5	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:56429106G>A	uc001sjb.1	+	9	1908	c.1749G>A	c.(1747-1749)AAG>AAA	p.K583K	IKZF4_uc010sqa.1_Silent_p.K536K|IKZF4_uc001sjc.1_Silent_p.K583K|IKZF4_uc001sjd.1_Silent_p.K481K|IKZF4_uc009zoi.1_Silent_p.K538K|IKZF4_uc001sje.1_Silent_p.K542K	NM_022465	NP_071910	Q9H2S9	IKZF4_HUMAN	zinc finger protein, subfamily 1A, 4	583					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGGAGCATAAGGTGGGCTAGC	0.547													7	191					0	0	0	0	A	56429106	A	A	56429106	2	1	166	1	0	0	0	0	0	0	0	1	7656	991	35	4		4	IKZF4	12	56429106	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3082541	56429106	77422789	723	31051											
INHBC	3626	broad.mit.edu	37	chr12	57843137	57843137	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggtgacagggaggtccagCaggccagtctcatgttcttt	7	11	13	10	0	2	1	1	1	2	0	4	2	3	2	2	4	1	2	2	4	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:57843137C>G	uc001snv.1	+	2	518	c.391C>G	c.(391-393)CAG>GAG	p.Q131E		NM_005538	NP_005529	P55103	INHBC_HUMAN	inhibin beta C chain preproprotein	131					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding				0						GGAGGTCCAGCAGGCCAGTCT	0.507													65	181					0	0	0	0	G	57843137	G	G	57843137	3	3	166	1	0	0	0	0	1	0	0	0	7782	711	25	4	397	4	INHBC	12	57843137	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1414031	57843137	76008758	724	31052											
METTL1	4234	broad.mit.edu	37	chr12	58163103	58163103	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccaggtcctccagaggcaCacgctcaaacagtgggtgct	10	6	11	14	1	1	1	1	0	0	1	3	1	3	1	3	3	2	3	3	3	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:58163103C>A	uc010ssd.1	-	5	706	c.658G>T	c.(658-660)GTG>TTG	p.V220L	CYP27B1_uc001spz.1_5'Flank|CYP27B1_uc001sqa.1_5'Flank|METTL1_uc009zqc.2_3'UTR	NM_005371	NP_005362	Q9UBP6	TRMB_HUMAN	methyltransferase-like protein 1 isoform a	220						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding				0	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			TCCAGAGGCACACGCTCAAAC	0.537													11	21					3.86212e-05	6.52565e-05	1	0	A	58163103	A	A	58163103	3	1	166	1	0	0	0	0	1	0	0	0	9546	478	17	4	180	4	METTL1	12	58163103	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	319966	58163103	75688792	725	31053											
SLC16A7	9194	broad.mit.edu	37	chr12	60173400	60173400	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatctaaacattcggaagaTgttaacgtcaaagtttcaaa	18	11	6	6	2	3	1	2	0	1	1	4	2	3	2	0	1	2	2	0	1	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:60173400T>C	uc001sqs.2	+	6	1676	c.1377T>C	c.(1375-1377)GAT>GAC	p.D459D	SLC16A7_uc001sqt.2_Silent_p.D459D|SLC16A7_uc001squ.2_Silent_p.D459D|SLC16A7_uc009zqi.2_Silent_p.D360D|SLC16A7_uc010ssi.1_Silent_p.D360D	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	459	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	ATTCGGAAGATGTTAACGTCA	0.368													7	19					0	0	0	0	C	60173400	C	C	60173400	2	2	166	1	0	0	0	0	0	0	0	1	14478	1461	51	5		5	SLC16A7	12	60173400	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2010297	60173400	73678495	726	31054											
USP15	9958	broad.mit.edu	37	chr12	62715352	62715352	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaccactgaataaaccaGacagcaccattcaggatgct	15	8	7	11	0	1	3	1	2	0	1	1	4	1	4	3	1	4	2	3	1	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:62715352G>T	uc001src.1	+	5	592	c.583G>T	c.(583-585)GAC>TAC	p.D195Y	USP15_uc001srb.1_Missense_Mutation_p.D195Y|USP15_uc001sra.2_Missense_Mutation_p.D195Y	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	195					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GAATAAACCAGACAGCACCAT	0.333													7	29					0.000274275	0.000453271	1	0	T	62715352	T	T	62715352	3	4	166	1	0	0	0	0	1	0	0	0	17114	942	33	2	601	2	USP15	12	62715352	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2541952	62715352	71136543	727	31055											
AVPR1A	552	broad.mit.edu	37	chr12	63543951	63543951	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgggcgccacaaagatgccGcccgtcatccaggtcacgta	10	5	11	15	5	2	1	2	0	0	1	3	1	3	1	4	2	1	1	4	2	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:63543951G>T	uc001sro.1	-	1	2640	c.666C>A	c.(664-666)GGC>GGA	p.G222G		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	222	Helical; Name=5; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	CAAAGATGCCGCCCGTCATCC	0.612													34	93					3.90053e-15	8.41038e-15	1	0	T	63543951	T	T	63543951	2	4	166	1	0	0	0	0	0	0	0	1	1233	1074	38	3		3	AVPR1A	12	63543951	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	828599	63543951	70307944	728	31056											
TMBIM4	51643	broad.mit.edu	37	chr12	66531826	66531826	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggctgatggcagctaataCgtactcttcaggtgacagtt	10	11	12	8	1	2	2	1	2	1	0	2	3	2	2	0	3	3	5	0	3	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:66531826C>T	uc001stc.2	-	7	707	c.631G>A	c.(631-633)GTA>ATA	p.V211I	LLPH_uc010ssx.1_RNA|TMBIM4_uc001std.2_Missense_Mutation_p.V180I|TMBIM4_uc009zqr.2_Missense_Mutation_p.V258I|TMBIM4_uc001ste.2_RNA|TMBIM4_uc001stf.2_3'UTR|TMBIM4_uc009zqs.2_3'UTR	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	211	Helical; (Potential).					integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)		GCAGCTAATACGTACTCTTCA	0.413													22	47					0	0	0	0	T	66531826	T	T	66531826	3	4	166	1	0	0	0	0	1	0	0	0	16048	536	19	1	89	1	TMBIM4	12	66531826	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2987875	66531826	67320069	729	31057											
IRAK3	11213	broad.mit.edu	37	chr12	66638281	66638282	+	Frame_Shift_Ins	INS	-	GATGA	GATGA																															ttagtgcaaacatccttttgINSgatgatcagtttcaacccaa																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:66638281_66638282insGATGA	uc001sth.2	+	9	1005_1006	c.903_904insGATGA	c.(901-906)TTGGATfs	p.L301fs	IRAK3_uc010ssy.1_Frame_Shift_Ins_p.L240fs	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	301_302	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		ACATCCTTTTGGATGATCAGTT	0.396													---	---	---								GATGA	66638282	GATGA	GATGA	66638281	7	5	166	1	0	1	1	0	0	0	0	0	7863	1339	47	0	937	0	IRAK3	12	66638281	Frame_Shift_Ins	INS	-	TCGA-CR-7402-01A-11D-2012-08	106455	66638281	67213614	730	31058											
DYRK2	8445	broad.mit.edu	37	chr12	68051900	68051900	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtatggcatgcccattgatAtgtggagcctgggctgcatt	7	12	14	8	0	0	1	0	1	0	0	0	2	0	2	2	4	3	4	2	4	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:68051900A>T	uc001str.3	+	3	1615	c.1213A>T	c.(1213-1215)ATG>TTG	p.M405L	DYRK2_uc001sts.3_Missense_Mutation_p.M332L	NM_006482	NP_006473	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	405	Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(1)|central_nervous_system(1)	4			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)		GCCCATTGATATGTGGAGCCT	0.542													11	30					0	0	0	0	T	68051900	T	T	68051900	3	4	166	1	0	0	0	0	1	0	0	0	4878	449	16	5	1223	5	DYRK2	12	68051900	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1413619	68051900	65799995	731	31059											
MDM2	4193	broad.mit.edu	37	chr12	69203025	69203025	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatgtctgtacctactgatGgtgctgtaaccacctcacag	10	11	8	12	0	2	1	1	1	1	0	2	1	2	1	3	1	4	3	3	1	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:69203025G>C	uc001sui.2	+	2	339	c.52G>C	c.(52-54)GGT>CGT	p.G18R	MDM2_uc009zri.2_Missense_Mutation_p.G18R|MDM2_uc009zqx.2_Missense_Mutation_p.G18R|MDM2_uc009zqw.2_Missense_Mutation_p.G18R|MDM2_uc001suk.2_Missense_Mutation_p.G18R|MDM2_uc009zqy.1_Missense_Mutation_p.G7R|MDM2_uc001sun.3_Missense_Mutation_p.G7R|MDM2_uc009zqz.2_Missense_Mutation_p.G12R|MDM2_uc009zra.2_Missense_Mutation_p.G12R|MDM2_uc009zrb.1_RNA|MDM2_uc001sum.1_Missense_Mutation_p.G7R|MDM2_uc009zrd.2_5'UTR|MDM2_uc009zrc.2_5'UTR|MDM2_uc009zre.2_Missense_Mutation_p.G7R|MDM2_uc009zrf.2_5'UTR|MDM2_uc001suo.2_Missense_Mutation_p.G7R|MDM2_uc009zrg.2_Missense_Mutation_p.G7R|MDM2_uc009zrh.2_Missense_Mutation_p.G7R	NM_002392	NP_002383	Q00987	MDM2_HUMAN	mouse double minute 2 homolog isoform MDM2	12	Necessary for interaction with USP2.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			ACCTACTGATGGTGCTGTAAC	0.368			A		sarcoma|glioma|colorectal|other								134	285					0	0	0	0	C	69203025	C	C	69203025	3	2	166	1	0	0	0	0	1	0	0	0	9466	1348	47	4	58	4	MDM2	12	69203025	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1151125	69203025	64648870	732	31060											
PTPRR	5801	broad.mit.edu	37	chr12	71078504	71078504	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctaatataattagcattaaTgtaggtgctcaatgaatcgg	14	13	8	6	1	1	1	1	1	0	0	2	1	1	1	1	2	2	3	1	2	8	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:71078504T>C	uc001swi.1	-	9	1755	c.1339A>G	c.(1339-1341)ATT>GTT	p.I447V	PTPRR_uc001swh.1_Missense_Mutation_p.I202V|PTPRR_uc009zrs.2_Missense_Mutation_p.I296V|PTPRR_uc010stq.1_Missense_Mutation_p.I335V|PTPRR_uc010str.1_Missense_Mutation_p.I296V	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	447	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TTAGCATTAATGTAGGTGCTC	0.299													24	59					0	0	0	0	C	71078504	C	C	71078504	3	2	166	1	0	0	0	0	1	0	0	0	12875	1464	51	5	658	5	PTPRR	12	71078504	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1875479	71078504	62773391	733	31061											
TPH2	121278	broad.mit.edu	37	chr12	72335486	72335487	+	Frame_Shift_Ins	INS	-	T	T																															tgaagaatgaagttggtggaINSttggtaaaagcactgaggct																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:72335486_72335487insT	uc009zrw.1	+	2	369_370	c.228_229insT	c.(226-231)GGATTGfs	p.G76fs	TPH2_uc001swy.2_5'UTR	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	76_77	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	AAGTTGGTGGATTGGTAAAAGC	0.416													---	---	---								T	72335487	T	T	72335486	7	5	166	1	0	1	1	0	0	0	0	0	16469	320	12	0	234	0	TPH2	12	72335486	Frame_Shift_Ins	INS	-	TCGA-CR-7402-01A-11D-2012-08	1256982	72335486	61516409	734	31062											
CAPS2	84698	broad.mit.edu	37	chr12	75687068	75687068	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgatcaatatttgtgattCggagtttaagtaatgtgttt	10	20	9	2	1	1	2	1	2	0	0	2	3	1	3	0	1	0	3	0	1	4	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:75687068C>A	uc001sxk.3	-	13	1378	c.1181G>T	c.(1180-1182)CGA>CTA	p.R394L	CAPS2_uc001sxm.3_Missense_Mutation_p.R162L|CAPS2_uc009zsa.2_5'UTR|CAPS2_uc001sxi.3_Missense_Mutation_p.R130L|CAPS2_uc001sxj.3_Missense_Mutation_p.R305L|CAPS2_uc001sxl.3_Missense_Mutation_p.R375L	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	394							calcium ion binding			ovary(2)	2						ATTTGTGATTCGGAGTTTAAG	0.318													19	52					5.3912e-06	9.37601e-06	1	0	A	75687068	A	A	75687068	3	1	166	1	0	0	0	0	1	0	0	0	2650	884	31	3	516	3	CAPS2	12	75687068	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3351582	75687068	58164827	735	31063											
NAV3	89795	broad.mit.edu	37	chr12	78400500	78400500	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttcaagctagtcaatgcccgGactgctttacgccccccgca	8	9	8	16	3	2	0	2	0	0	0	2	1	2	1	4	1	4	3	4	1	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:78400500G>C	uc001syp.2	+	8	1355	c.1182G>C	c.(1180-1182)CGG>CGC	p.R394R	NAV3_uc001syo.2_Silent_p.R394R	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	394						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCAATGCCCGGACTGCTTTAC	0.498										HNSCC(70;0.22)			25	69					0	0	0	0	C	78400500	C	C	78400500	2	2	166	1	0	0	0	0	0	0	0	1	10238	1161	41	2		2	NAV3	12	78400500	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2713432	78400500	55451395	736	31064											
ACSS3	79611	broad.mit.edu	37	chr12	81627154	81627154	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatgataccatggatgctggTtacatggatgaagaaggcta	13	11	12	5	0	0	3	0	2	0	1	0	5	0	5	1	4	3	3	1	4	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:81627154T>C	uc001szl.1	+	13	1714	c.1623T>C	c.(1621-1623)GGT>GGC	p.G541G	ACSS3_uc001szm.1_Silent_p.G540G|ACSS3_uc001szn.1_Silent_p.G223G	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	541						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TGGATGCTGGTTACATGGATG	0.343													31	99					0	0	0	0	C	81627154	C	C	81627154	2	2	166	1	0	0	0	0	0	0	0	1	190	1712	60	5		5	ACSS3	12	81627154	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	3226654	81627154	52224741	737	31065											
SLC6A15	55117	broad.mit.edu	37	chr12	85255711	85255711	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgaaaactacagggactggGagtattgcaaagacaaccag	17	6	11	7	0	0	2	0	1	0	1	0	4	0	4	1	2	4	2	1	2	6	3	rs149254147		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:85255711G>T	uc001szv.2	-	12	2386	c.1893C>A	c.(1891-1893)CTC>CTA	p.L631L	SLC6A15_uc010sul.1_Silent_p.L524L|SLC6A15_uc001szw.1_Intron	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	631	Helical; Name=12; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						CAGGGACTGGGAGTATTGCAA	0.393													19	88					3.57192e-18	8.11236e-18	1	0	T	85255711	T	T	85255711	2	4	166	1	0	0	0	0	0	0	0	1	14742	1161	41	2		2	SLC6A15	12	85255711	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3628557	85255711	48596184	738	31066											
SLC6A15	55117	broad.mit.edu	37	chr12	85266419	85266419	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattttacaggaattgagatGaagagcaggaaactcttctt	15	12	9	5	0	2	3	0	2	2	2	2	6	2	5	0	2	3	1	0	2	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:85266419G>A	uc001szv.2	-	8	1757	c.1264C>T	c.(1264-1266)CAT>TAT	p.H422Y	SLC6A15_uc010sul.1_Missense_Mutation_p.H315Y|SLC6A15_uc001szw.1_Missense_Mutation_p.H130Y	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	422	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						GAATTGAGATGAAGAGCAGGA	0.308													20	36					0	0	0	0	A	85266419	A	A	85266419	3	1	166	1	0	0	0	0	1	0	0	0	14742	1290	45	2	948	2	SLC6A15	12	85266419	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	10708	85266419	48585476	739	31067											
C12orf29	91298	broad.mit.edu	37	chr12	88433979	88433979	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaaggcattagatgcagatAtatacagtgcaattccaaca	17	9	7	8	0	0	2	0	0	0	2	1	2	1	2	1	1	4	3	1	1	7	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:88433979A>T	uc001tao.2	+	2	303	c.145A>T	c.(145-147)ATA>TTA	p.I49L	C12orf29_uc001tap.2_Intron|C12orf29_uc009zsk.2_Intron	NM_001009894	NP_001009894	Q8N999	CL029_HUMAN	hypothetical protein LOC91298	49											0						AGATGCAGATATATACAGTGC	0.308													23	42					0	0	0	0	T	88433979	T	T	88433979	3	4	166	1	0	0	0	0	1	0	0	0	1686	449	16	5	151	5	C12orf29	12	88433979	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	3167560	88433979	45417916	740	31068											
CCDC38	120935	broad.mit.edu	37	chr12	96312654	96312654	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgattttaattaaactttacCgtttcctttgctgccatttc	8	20	4	9	1	0	1	0	1	0	0	2	1	1	1	3	0	4	2	3	0	4	8	rs139084164		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:96312654C>A	uc001tek.1	-	3	372	c.138G>T	c.(136-138)ACG>ACT	p.T46T		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	46										skin(1)	1						TAAACTTTACCGTTTCCTTTG	0.363													14	46					1.15088e-07	2.08863e-07	1	0	A	96312654	A	A	96312654	2	1	166	1	0	0	0	0	0	0	0	1	2823	666	23	3		3	CCDC38	12	96312654	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	7878675	96312654	37539241	741	31069											
C12orf63	374467	broad.mit.edu	37	chr12	97158856	97158856	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttatgcattaattgtaggTcagtgaagctgtgctggcaa	11	14	11	5	0	1	1	1	1	0	0	1	1	1	1	0	2	3	5	0	2	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:97158856T>C	uc001tet.1	+	27	3494	c.3416T>C	c.(3415-3417)GTC>GCC	p.V1139A		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1139										skin(6)|ovary(1)	7						TAATTGTAGGTCAGTGAAGCT	0.274													15	57					0	0	0	0	C	97158856	C	C	97158856	3	2	166	1	0	0	0	0	1	0	0	0	1712	1681	58	5	3518	5	C12orf63	12	97158856	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	846202	97158856	36693039	742	31070											
IKBIP	121457	broad.mit.edu	37	chr12	99007656	99007656	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatctatctgtatgtttgtCgaagtcactctttagttcgg	9	17	8	7	2	4	0	1	0	3	0	6	1	4	0	0	1	0	3	0	1	5	6	rs147943089	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:99007656C>A	uc001tfv.2	-	3	870	c.760G>T	c.(760-762)GAC>TAC	p.D254Y	IKBIP_uc001tfw.2_3'UTR	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	254					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0						GTATGTTTGTCGAAGTCACTC	0.378													20	68					2.4624e-09	4.68573e-09	1	0	A	99007656	A	A	99007656	3	1	166	1	0	0	0	0	1	0	0	0	7648	884	31	3	296	3	IKBIP	12	99007656	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1848800	99007656	34844239	743	31071											
NR1H4	9971	broad.mit.edu	37	chr12	100928694	100928694	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taactgaaattcagtgtaaaTctaagcgactgagaaaaaat	19	10	7	5	1	2	2	1	2	1	1	2	4	2	2	0	0	2	1	0	0	8	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:100928694T>C	uc001tht.1	+	4	683	c.655T>C	c.(655-657)TCT>CCT	p.S219P	NR1H4_uc001thp.1_Missense_Mutation_p.S205P|NR1H4_uc001thq.1_Missense_Mutation_p.S209P|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Missense_Mutation_p.S209P|NR1H4_uc010svk.1_Missense_Mutation_p.S158P|NR1H4_uc001ths.1_Missense_Mutation_p.S215P	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	219					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TCAGTGTAAATCTAAGCGACT	0.413													16	21					0	0	0	0	C	100928694	C	C	100928694	3	2	166	1	0	0	0	0	1	0	0	0	10673	1435	50	5	627	5	NR1H4	12	100928694	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1921038	100928694	32923201	744	31072											
ANO4	121601	broad.mit.edu	37	chr12	101491468	101491468	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctacttgaggctgataaaCaggtggagactagaagaggt	13	8	14	6	0	0	5	0	2	0	3	0	6	0	5	1	4	2	1	1	4	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:101491468C>A	uc010svm.1	+	20	2462	c.1890C>A	c.(1888-1890)AAC>AAA	p.N630K	ANO4_uc001thw.2_Missense_Mutation_p.N595K|ANO4_uc001thx.2_Missense_Mutation_p.N630K|ANO4_uc001thy.2_Missense_Mutation_p.N150K	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	630	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GGCTGATAAACAGGTGGAGAC	0.428										HNSCC(74;0.22)			20	52					2.39556e-15	5.17104e-15	1	0	A	101491468	A	A	101491468	3	1	166	1	0	0	0	0	1	0	0	0	699	477	17	4	1855	4	ANO4	12	101491468	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	562774	101491468	32360427	745	31073											
SLC5A8	160728	broad.mit.edu	37	chr12	101603614	101603614	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgaaggtgccgatgccccGtggcgtgtccatggccgcac	6	6	14	15	5	0	0	0	0	0	0	1	2	1	0	5	3	2	1	5	3	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:101603614G>T	uc001thz.3	-	1	403	c.13C>A	c.(13-15)CGG>AGG	p.R5R		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	5	Extracellular (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						CCGATGCCCCGTGGCGTGTCC	0.706													7	13					0.000157383	0.00026186	1	0	T	101603614	T	T	101603614	2	4	166	1	0	0	0	0	0	0	0	1	14735	1144	40	3		3	SLC5A8	12	101603614	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	112146	101603614	32248281	746	31074											
APPL2	55198	broad.mit.edu	37	chr12	105600962	105600962	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccgccgggccgcggccacCtcttttccgacttcggtctt	2	12	10	17	6	2	0	0	0	2	0	5	1	4	0	6	3	0	0	6	3	0	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:105600962C>G	uc001tlf.1	-	8	716	c.498G>C	c.(496-498)GAG>GAC	p.E166D	APPL2_uc010swt.1_Missense_Mutation_p.E123D|APPL2_uc001tlg.1_5'UTR|APPL2_uc010swu.1_Missense_Mutation_p.E172D|APPL2_uc009zuq.2_Missense_Mutation_p.E123D	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	166	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CCGCGGCCACCTCTTTTCCGA	0.512													14	35					0	0	0	0	G	105600962	G	G	105600962	3	3	166	1	0	0	0	0	1	0	0	0	818	680	24	4	1552	4	APPL2	12	105600962	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3997348	105600962	28250933	747	31075											
NUAK1	9891	broad.mit.edu	37	chr12	106466568	106466568	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagagtggactcccacaaaaCgtttgtaagaacttatcctt	13	12	7	9	1	0	2	0	0	0	2	2	3	2	3	2	1	2	2	2	1	6	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:106466568C>G	uc001tlj.1	-	5	2013	c.633G>C	c.(631-633)ACG>ACC	p.T211T		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	211	Protein kinase.			T->A: Prevents phosphorylation and activation by STK11/LKB1 complex.			ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						TCCCACAAAACGTTTGTAAGA	0.488													21	50					0	0	0	0	G	106466568	G	G	106466568	2	3	166	1	0	0	0	0	0	0	0	1	10766	523	19	3		3	NUAK1	12	106466568	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	865606	106466568	27385327	748	31076											
BTBD11	121551	broad.mit.edu	37	chr12	108029160	108029160	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaaacggaaacagacctcGcgcttgggtgagtggttccc	10	8	12	11	3	1	2	1	1	0	1	3	3	2	3	2	3	2	2	2	3	2	2	rs149726114	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:108029160G>C	uc001tmk.1	+	12	3251	c.2730G>C	c.(2728-2730)TCG>TCC	p.S910S	BTBD11_uc009zut.1_Silent_p.S791S|BTBD11_uc001tmj.2_Silent_p.S910S|BTBD11_uc001tml.1_Silent_p.S447S|BTBD11_uc001tmm.1_5'UTR	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	910						integral to membrane	DNA binding			skin(2)|ovary(1)	3						AACAGACCTCGCGCTTGGGTG	0.552													22	49					0	0	0	0	C	108029160	C	C	108029160	2	2	166	1	0	0	0	0	0	0	0	1	1544	1074	38	3		3	BTBD11	12	108029160	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1562592	108029160	25822735	749	31077											
CMKLR1	1240	broad.mit.edu	37	chr12	108686440	108686440	+	Frame_Shift_Del	DEL	G	-	-																															aaaacccagtggtagtccatGgcggcataggtgatatggat																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:108686440delG	uc009zuw.2	-	3	491	c.300delC	c.(298-300)GCCfs	p.A100fs	CMKLR1_uc001tmw.2_Frame_Shift_Del_p.A100fs|CMKLR1_uc001tmv.2_Frame_Shift_Del_p.A98fs|CMKLR1_uc009zuv.2_Frame_Shift_Del_p.A100fs	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	100	Extracellular (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						GGTAGTCCATGGCGGCATAGG	0.498													---	---	---								-	108686440	-	-	108686440	7	5	166	1	0	1	0	1	0	0	0	0	3594	1335	47	0	825	0	CMKLR1	12	108686440	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	657280	108686440	25165455	750	31078											
SART3	9733	broad.mit.edu	37	chr12	108930562	108930562	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccagctctttactggagtCtaacggaaagtgcaaaaaaa	15	9	8	9	1	2	0	0	0	2	0	3	2	3	2	1	2	4	2	1	2	6	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:108930562C>A	uc001tmz.1	-	10	1545	c.1310_splice	c.e10-1	p.D437_splice	SART3_uc001tmy.1_Splice_Site|SART3_uc009zux.1_Splice_Site_p.D49_splice|SART3_uc010swx.1_Splice_Site_p.D401_splice|SART3_uc010swy.1_Splice_Site_p.D323_splice|SART3_uc010swz.1_Splice_Site_p.D437_splice|SART3_uc001tna.1_Splice_Site	NM_014706	NP_055521	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T						RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			pancreas(1)	1						TTACTGGAGTCTAACGGAAAG	0.448									Porokeratosis				12	22					2.80697e-09	5.31049e-09	1	0	A	108930562	A	A	108930562	5	1	166	1	0	0	0	0	0	0	1	0	13912	927	32	2	1622	2	SART3	12	108930562	Splice_Site	SNP	C	TCGA-CR-7402-01A-11D-2012-08	244122	108930562	24921333	751	31079											
ALKBH2	121642	broad.mit.edu	37	chr12	109530453	109530453	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgagtggcctccattccCtggggcctctctcctgggcc	2	11	12	16	0	1	1	0	1	1	0	5	1	4	1	6	4	1	1	6	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:109530453C>A	uc001tnx.2	-	2	532	c.139G>T	c.(139-141)GGG>TGG	p.G47W	ALKBH2_uc001tny.2_Missense_Mutation_p.G47W|ALKBH2_uc010sxj.1_Missense_Mutation_p.G47W|ALKBH2_uc009zvd.2_Missense_Mutation_p.G47W|ALKBH2_uc010sxk.1_Missense_Mutation_p.G47W	NM_001145374	NP_001138846	Q6NS38	ALKB2_HUMAN	AlkB homolog 2	47					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	CCTCCATTCCCTGGGGCCTCT	0.582								Direct_reversal_of_damage					50	115					1.00776e-21	2.39709e-21	1	0	A	109530453	A	A	109530453	3	1	166	1	0	0	0	0	1	0	0	0	527	681	24	4	658	4	ALKBH2	12	109530453	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	599891	109530453	24321442	752	31080											
ACACB	32	broad.mit.edu	37	chr12	109650676	109650676	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gactgccatgcagccaccctGcagcggaaggctgatcgaga	10	5	13	13	2	0	2	0	1	0	1	1	5	0	3	3	2	5	3	3	2	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:109650676G>C	uc001tob.2	+	22	3404	c.3285G>C	c.(3283-3285)CTG>CTC	p.L1095L	ACACB_uc001toc.2_Silent_p.L1095L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1095					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CAGCCACCCTGCAGCGGAAGG	0.542													45	114					0	0	0	0	C	109650676	C	C	109650676	2	2	166	1	0	0	0	0	0	0	0	1	107	1306	46	4		4	ACACB	12	109650676	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	120223	109650676	24201219	753	31081											
UBE3B	89910	broad.mit.edu	37	chr12	109959106	109959106	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatcatcaagagagtttttGacccagcactcaatctgttc	12	12	7	10	0	4	3	3	1	1	2	5	4	4	3	1	0	1	3	1	0	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:109959106G>C	uc001top.2	+	20	2833	c.2230G>C	c.(2230-2232)GAC>CAC	p.D744H	UBE3B_uc001toq.2_Missense_Mutation_p.D744H|UBE3B_uc001tos.2_Missense_Mutation_p.D171H|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.D744H	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	744	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GAGAGTTTTTGACCCAGCACT	0.488													31	99					0	0	0	0	C	109959106	C	C	109959106	3	2	166	1	0	0	0	0	1	0	0	0	16948	1290	45	2	2300	2	UBE3B	12	109959106	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	308430	109959106	23892789	754	31082											
C12orf51	283450	broad.mit.edu	37	chr12	112670875	112670875	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtaccaagtcggaagggcCgtccttctgaactactgaaa	12	8	10	11	2	1	2	0	2	1	0	3	3	2	3	3	2	3	1	3	2	6	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:112670875C>G	uc009zwc.2	-	31	4682	c.4664G>C	c.(4663-4665)CGG>CCG	p.R1555P		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TCGGAAGGGCCGTCCTTCTGA	0.512													5	7					0	0	0	0	G	112670875	G	G	112670875	3	3	166	1	0	0	0	0	1	0	0	0	1702	652	23	3	7482	3	C12orf51	12	112670875	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2711769	112670875	21181020	755	31083											
RPH3A	22895	broad.mit.edu	37	chr12	113307719	113307719	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccctgacccagcctctgctcCcgggcgaggaaactatgggc	7	6	12	16	2	1	1	0	1	1	0	2	3	2	2	4	3	3	1	4	3	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:113307719C>A	uc010syl.1	+	10	1033	c.671C>A	c.(670-672)CCC>CAC	p.P224H	RPH3A_uc001ttz.2_Missense_Mutation_p.P224H|RPH3A_uc001tty.2_Missense_Mutation_p.P220H|RPH3A_uc009zwe.1_Missense_Mutation_p.P220H|RPH3A_uc010sym.1_Missense_Mutation_p.P175H|RPH3A_uc001tua.2_5'UTR	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	224	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GCCTCTGCTCCCGGGCGAGGA	0.562													29	62					3.99451e-17	8.92729e-17	1	0	A	113307719	A	A	113307719	3	1	166	1	0	0	0	0	1	0	0	0	13616	623	22	4	701	4	RPH3A	12	113307719	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	636844	113307719	20544176	756	31084											
RPH3A	22895	broad.mit.edu	37	chr12	113321158	113321158	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accccatctggaatgagaccCtcgtgtatcacggcatcacc	10	8	8	15	2	3	1	2	1	1	1	4	3	3	2	4	2	0	2	4	2	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:113321158C>T	uc010syl.1	+	16	1749	c.1387C>T	c.(1387-1389)CTC>TTC	p.L463F	RPH3A_uc001ttz.2_Missense_Mutation_p.L463F|RPH3A_uc001tty.2_Missense_Mutation_p.L459F|RPH3A_uc009zwe.1_Missense_Mutation_p.L459F|RPH3A_uc010sym.1_Missense_Mutation_p.L414F|RPH3A_uc001tua.2_Missense_Mutation_p.L223F	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	463	C2 1.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GAATGAGACCCTCGTGTATCA	0.562													10	23					0	0	0	0	T	113321158	T	T	113321158	3	4	166	1	0	0	0	0	1	0	0	0	13616	681	24	4	1441	4	RPH3A	12	113321158	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	13439	113321158	20530737	757	31085											
PRKAB1	5564	broad.mit.edu	37	chr12	120114377	120114377	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccccaggaccctaccatcagGagccctacgtctgcaaaccc	10	5	7	19	1	2	0	1	0	1	0	2	2	2	2	6	2	5	1	6	2	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:120114377G>T	uc009zwu.2	+	6	671	c.568G>T	c.(568-570)GAG>TAG	p.E190*	PRKAB1_uc001txg.2_Nonsense_Mutation_p.E190*	NM_006253	NP_006244	Q9Y478	AAKB1_HUMAN	AMP-activated protein kinase beta 1	190					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol					0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	CTACCATCAGGAGCCCTACGT	0.537													36	80					9.80977e-26	2.39441e-25	1	0	T	120114377	T	T	120114377	4	4	166	1	0	0	0	0	0	1	0	0	12557	1175	41	2	586	2	PRKAB1	12	120114377	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	6793219	120114377	13737518	758	31086											
CLIP1	6249	broad.mit.edu	37	chr12	122825411	122825411	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttaccttcggaactggctttCcgaagtgcatcaagatccaa	11	11	8	11	2	1	1	1	0	0	1	4	3	3	2	3	2	3	2	3	2	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:122825411C>T	uc001ucg.1	-	10	2446	c.2340G>A	c.(2338-2340)CGG>CGA	p.R780R	CLIP1_uc001uch.1_Silent_p.R769R|CLIP1_uc001uci.1_Silent_p.R734R|CLIP1_uc001ucj.1_Intron	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	780	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		AACTGGCTTTCCGAAGTGCAT	0.393													45	99					0	0	0	0	T	122825411	T	T	122825411	2	4	166	1	0	0	0	0	0	0	0	1	3547	842	30	2		2	CLIP1	12	122825411	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2711034	122825411	11026484	759	31087											
SBNO1	55206	broad.mit.edu	37	chr12	123780568	123780568	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgataggagatttacaagagGagacacacaatttgccggaa	16	8	11	6	1	0	4	0	1	0	3	0	7	0	5	1	3	2	0	1	3	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:123780568G>A	uc010tap.1	-	31	4069	c.4069C>T	c.(4069-4071)CCT>TCT	p.P1357S	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.P1356S|SBNO1_uc010taq.1_Missense_Mutation_p.P308S	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1357							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TTTACAAGAGGAGACACACAA	0.428													46	104					0	0	0	0	A	123780568	A	A	123780568	3	1	166	1	0	0	0	0	1	0	0	0	13927	1174	41	2	116	2	SBNO1	12	123780568	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	955157	123780568	10071327	760	31088											
DNAH10	196385	broad.mit.edu	37	chr12	124383262	124383262	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccaccatccagctggacGagctgaaccagaagctggcc	11	4	12	14	1	0	2	0	1	0	1	1	4	1	3	5	3	4	3	5	3	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:124383262G>T	uc001uft.3	+	55	9212	c.9187G>T	c.(9187-9189)GAG>TAG	p.E3063*		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3063	Potential.|Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CCAGCTGGACGAGCTGAACCA	0.617													3	12					6.4e-05	0.00010779	1	0	T	124383262	T	T	124383262	4	4	166	1	0	0	0	0	0	1	0	0	4620	1059	37	3	9405	3	DNAH10	12	124383262	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	602694	124383262	9468633	761	31089											
GLT1D1	144423	broad.mit.edu	37	chr12	129442110	129442110	+	Frame_Shift_Del	DEL	G	-	-																															gcaatggatttagaagtaccGgtattggccaggaacatccc																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:129442110delG	uc010tbh.1	+	12	825	c.816delG	c.(814-816)CCGfs	p.P272fs	GLT1D1_uc001uhx.1_Frame_Shift_Del_p.P187fs|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	267					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		TAGAAGTACCGGTATTGGCCA	0.527													---	---	---								-	129442110	-	-	129442110	7	5	166	1	0	1	0	1	0	0	0	0	6502	1103	39	0	587	0	GLT1D1	12	129442110	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	5058848	129442110	4409785	762	31090											
TMEM132D	121256	broad.mit.edu	37	chr12	130184929	130184929	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gactttgtcccgcaggatgtGggcttttagtttccagttaa	7	15	11	8	1	0	0	0	0	0	0	2	2	2	1	2	2	0	4	2	2	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:130184929G>T	uc009zyl.1	-	2	722	c.394C>A	c.(394-396)CAC>AAC	p.H132N		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	132	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CGCAGGATGTGGGCTTTTAGT	0.527													14	30					1.3612e-06	2.40573e-06	1	0	T	130184929	T	T	130184929	3	4	166	1	0	0	0	0	1	0	0	0	16113	1348	47	4	2937	4	TMEM132D	12	130184929	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	742819	130184929	3666966	763	31091											
PIWIL1	9271	broad.mit.edu	37	chr12	130831562	130831562	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaacaaatgaacttccacCtacatcaccaacttgtttgc	13	13	3	12	0	1	1	1	1	0	0	2	1	2	1	3	0	5	1	3	0	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:130831562C>A	uc001uik.2	+	6	698	c.608C>A	c.(607-609)CCT>CAT	p.P203H	PIWIL1_uc001uij.1_Missense_Mutation_p.P203H	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	203					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GAACTTCCACCTACATCACCA	0.303													17	36					6.94344e-10	1.34213e-09	1	0	A	130831562	A	A	130831562	3	1	166	1	0	0	0	0	1	0	0	0	12012	681	24	4	626	4	PIWIL1	12	130831562	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	646633	130831562	3020333	764	31092											
GPR133	283383	broad.mit.edu	37	chr12	131466553	131466553	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcggtggcagaggctctgtGgagctgtatacgcgggacaa	9	7	17	8	3	1	1	0	0	1	1	1	3	1	3	0	5	3	4	0	5	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:131466553G>A	uc001uit.3	+	5	994	c.435G>A	c.(433-435)GTG>GTA	p.V145V	GPR133_uc010tbm.1_Silent_p.V177V	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	145	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GAGGCTCTGTGGAGCTGTATA	0.587													38	71					0	0	0	0	A	131466553	A	A	131466553	2	1	166	1	0	0	0	0	0	0	0	1	6681	1335	47	4		4	GPR133	12	131466553	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	634991	131466553	2385342	765	31093											
POLE	5426	broad.mit.edu	37	chr12	133225973	133225973	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agccccgtggcaggaccatcCcggatggccccgggcctgag	6	4	15	16	3	0	1	0	1	0	0	1	3	1	3	7	5	1	1	7	5	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133225973C>A	uc001uks.1	-	31	3968	c.3924G>T	c.(3922-3924)CGG>CGT	p.R1308R	POLE_uc001ukr.1_Silent_p.R112R|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Silent_p.R1281R	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1308					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CAGGACCATCCCGGATGGCCC	0.647								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					17	50					9.16793e-09	1.71625e-08	1	0	A	133225973	A	A	133225973	2	1	166	1	0	0	0	0	0	0	0	1	12251	610	22	4		4	POLE	12	133225973	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1759420	133225973	625922	766	31094											
POLE	5426	broad.mit.edu	37	chr12	133234500	133234500	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagctcttgagccatttcCggagaaagtgcttcctcacc	10	10	9	12	1	2	3	1	1	1	2	4	4	4	3	4	1	3	2	4	1	2	3	rs114315196	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133234500C>T	uc001uks.1	-	27	3376	c.3332G>A	c.(3331-3333)CGG>CAG	p.R1111Q	POLE_uc001ukr.1_5'UTR|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.R1084Q	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1111					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GAGCCATTTCCGGAGAAAGTG	0.483								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					34	84					0	0	0	0	T	133234500	T	T	133234500	3	4	166	1	0	0	0	0	1	0	0	0	12251	652	23	1	3620	1	POLE	12	133234500	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8527	133234500	617395	767	31095											
POLE	5426	broad.mit.edu	37	chr12	133257867	133257867	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagtggcgccatcatcccTgagtgaaagaagggaacccc	12	5	13	11	1	1	3	1	2	0	1	2	5	2	5	4	3	1	0	4	3	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133257867T>A	uc001uks.1	-	2	107	c.63_splice	c.e2-1	p.R21_splice	POLE_uc010tbq.1_Splice_Site|POLE_uc009zyu.1_Splice_Site_p.R21_splice	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon						base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CCATCATCCCTGAGTGAAAGA	0.403								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					35	82					0	0	0	0	A	133257867	A	A	133257867	5	1	166	1	0	0	0	0	0	0	1	0	12251	1594	55	5	6991	5	POLE	12	133257867	Splice_Site	SNP	T	TCGA-CR-7402-01A-11D-2012-08	23367	133257867	594028	768	31096											
ZNF10	7556	broad.mit.edu	37	chr12	133732562	133732562	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctacaaatgccctgataatGacaactctcttactcatggt	12	12	5	12	0	2	2	1	2	1	0	3	2	2	2	2	1	4	0	2	1	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133732562G>A	uc009zzb.2	+	5	1177	c.730G>A	c.(730-732)GAC>AAC	p.D244N	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.D244N	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	244				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CCCTGATAATGACAACTCTCT	0.378													12	27					0	0	0	0	A	133732562	A	A	133732562	3	1	166	1	0	0	0	0	1	0	0	0	17779	1290	45	2	744	2	ZNF10	12	133732562	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	474695	133732562	119333	769	31097											
ZNF10	7556	broad.mit.edu	37	chr12	133733348	133733348	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccggaagaatgacctcattAagcaccagagaattcatgtt	14	10	8	9	1	2	3	2	1	0	2	3	5	3	4	3	1	1	2	3	1	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133733348A>T	uc009zzb.2	+	5	1963	c.1516A>T	c.(1516-1518)AAG>TAG	p.K506*	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Nonsense_Mutation_p.K506*	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	506	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TGACCTCATTAAGCACCAGAG	0.413													13	42					0	0	0	0	T	133733348	T	T	133733348	4	4	166	1	0	0	0	0	0	1	0	0	17779	363	13	5	1530	5	ZNF10	12	133733348	Nonsense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	786	133733348	118547	770	31098											
TUBA3C	7278	broad.mit.edu	37	chr13	19753636	19753636	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaattccatgttccaggcagTacagttcccagcaggcattg	10	10	10	11	0	0	0	0	0	0	0	3	1	3	0	3	2	2	6	3	2	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:19753636T>A	uc009zzj.2	-	2	120	c.71A>T	c.(70-72)TAC>TTC	p.Y24F		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	24					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TTCCAGGCAGTACAGTTCCCA	0.512													50	45					0	0	0	0	A	19753636	A	A	19753636	3	1	166	1	0	0	0	0	1	0	0	0	16814	1638	57	5	1297	5	TUBA3C	13	19753636	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08		19753636	95416242	771	31099											
RNF17	56163	broad.mit.edu	37	chr13	25406105	25406105	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcaagataaatttatgacatGttcagttatcagtaagttcc	14	15	6	6	0	3	2	3	1	0	1	4	2	4	2	1	0	0	4	1	0	6	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:25406105G>T	uc001upr.2	+	18	2512	c.2471G>T	c.(2470-2472)TGT>TTT	p.C824F	RNF17_uc010tdd.1_Missense_Mutation_p.C683F|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.C824F|RNF17_uc001ups.2_Missense_Mutation_p.C763F|RNF17_uc010aac.2_Missense_Mutation_p.C22F	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	824					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTTATGACATGTTCAGTTATC	0.259													6	12					0.00116845	0.00191324	1	0	T	25406105	T	T	25406105	3	4	166	1	0	0	0	0	1	0	0	0	13526	1377	48	4	2541	4	RNF17	13	25406105	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5652469	25406105	89763773	772	31100											
PABPC3	5042	broad.mit.edu	37	chr13	25671150	25671150	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagctcagaaaaaagtggaaCggcagacggaacttaagcgc	16	4	13	8	3	1	2	1	0	0	2	1	5	1	4	0	3	4	2	0	3	6	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:25671150C>A	uc001upy.2	+	1	875	c.814C>A	c.(814-816)CGG>AGG	p.R272R		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	272					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAAAGTGGAACGGCAGACGGA	0.398													30	37					7.26314e-15	1.55582e-14	1	0	A	25671150	A	A	25671150	2	1	166	1	0	0	0	0	0	0	0	1	11419	527	19	3		3	PABPC3	13	25671150	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	265045	25671150	89498728	773	31101											
ATP8A2	51761	broad.mit.edu	37	chr13	26343303	26343303	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatccagacagcccacgtggGtgtgggaatcagtgggaatg	10	7	16	8	1	1	1	1	0	0	1	2	4	2	3	2	3	1	0	2	3	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:26343303G>T	uc001uqk.2	+	26	2646	c.2504G>T	c.(2503-2505)GGT>GTT	p.G835V	ATP8A2_uc010tdi.1_Missense_Mutation_p.G795V|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.G385V	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	795	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GCCCACGTGGGTGTGGGAATC	0.592													20	52					3.5997e-14	7.58646e-14	1	0	T	26343303	T	T	26343303	3	4	166	1	0	0	0	0	1	0	0	0	1195	1261	44	4	2606	4	ATP8A2	13	26343303	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	672153	26343303	88826575	774	31102											
FLT3	2322	broad.mit.edu	37	chr13	28592684	28592684	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatcttcaccactttcccgtGggtgacaagcacgttcctgg	7	12	9	13	2	2	1	1	1	1	0	4	1	4	1	3	2	1	2	3	2	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:28592684G>C	uc001urw.2	-	20	2543	c.2461C>G	c.(2461-2463)CAC>GAC	p.H821D	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Intron	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	821	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACTTTCCCGTGGGTGACAAGC	0.468			Mis|O		AML|ALL								19	32					0	0	0	0	C	28592684	C	C	28592684	3	2	166	1	0	0	0	0	1	0	0	0	5974	1348	47	4	540	4	FLT3	13	28592684	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2249381	28592684	86577194	775	31103											
FREM2	341640	broad.mit.edu	37	chr13	39264040	39264040	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagtgagacagagttgcaCgtgaatgatgtagacactga	13	9	13	6	1	0	7	0	5	0	3	0	8	0	7	0	0	1	3	0	0	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:39264040C>A	uc001uwv.2	+	1	2868	c.2559C>A	c.(2557-2559)CAC>CAA	p.H853Q		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	853	CSPG 5.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAGAGTTGCACGTGAATGATG	0.502													13	28					5.50884e-06	9.56361e-06	1	0	A	39264040	A	A	39264040	3	1	166	1	0	0	0	0	1	0	0	0	6079	535	19	3	2561	3	FREM2	13	39264040	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	10671356	39264040	75905838	776	31104											
RB1	5925	broad.mit.edu	37	chr13	48955409	48955409	+	Frame_Shift_Del	DEL	G	-	-																															catctcagaatcttgattctGgaacagatttgtctttccca																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:48955409delG	uc001vcb.2	+	17	1691	c.1525delG	c.(1525-1527)GGAfs	p.G509fs		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	509	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTTGATTCTGGAACAGATTT	0.294		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			---	---	---								-	48955409	-	-	48955409	7	5	166	1	0	1	0	1	0	0	0	0	13163	1349	47	0	1591	0	RB1	13	48955409	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	9691369	48955409	66214469	777	31105											
CYSLTR2	57105	broad.mit.edu	37	chr13	49281445	49281445	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctctgtgggatcatatggatCcttatcatggcttcctcaat	8	15	8	10	0	4	0	3	0	1	0	6	2	6	2	2	3	0	1	2	3	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:49281445C>A	uc010acx.1	+	6	1175	c.492C>A	c.(490-492)ATC>ATA	p.I164I	CYSLTR2_uc010acy.1_Silent_p.I164I|CYSLTR2_uc010acz.1_Silent_p.I164I|CYSLTR2_uc010ada.1_Silent_p.I164I|CYSLTR2_uc010adb.1_Silent_p.I164I|CYSLTR2_uc010adc.1_Silent_p.I164I|CYSLTR2_uc010add.1_Silent_p.I164I|CYSLTR2_uc010acw.1_Silent_p.I164I|CYSLTR2_uc001vck.2_Silent_p.I164I	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	164	Helical; Name=4; (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TCATATGGATCCTTATCATGG	0.493													53	65					5.13769e-22	1.22654e-21	1	0	A	49281445	A	A	49281445	2	1	166	1	0	0	0	0	0	0	0	1	4219	845	30	2		2	CYSLTR2	13	49281445	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	326036	49281445	65888433	778	31106											
NEK5	341676	broad.mit.edu	37	chr13	52676308	52676308	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tatggatggtcggtctcgagGagatacttgaaagagctgag	11	10	15	5	2	1	4	0	2	1	2	3	7	1	5	0	4	2	1	0	4	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:52676308G>A	uc001vge.2	-	10	870	c.730C>T	c.(730-732)CCT>TCT	p.P244S	NEK5_uc001vgf.2_Missense_Mutation_p.P244S	NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	244	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CGGTCTCGAGGAGATACTTGA	0.423													5	149					0	0	0	0	A	52676308	A	A	52676308	3	1	166	1	0	0	0	0	1	0	0	0	10381	1174	41	2	1448	2	NEK5	13	52676308	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3394863	52676308	62493570	779	31107											
PCDH17	27253	broad.mit.edu	37	chr13	58208274	58208274	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtctgtgaatcccacgaacGgggccatctacgccctgcgc	7	8	11	15	4	2	1	0	1	2	0	3	2	3	1	3	2	3	0	3	2	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:58208274G>T	uc001vhq.1	+	1	2486	c.1594G>T	c.(1594-1596)GGG>TGG	p.G532W	PCDH17_uc010aec.1_Missense_Mutation_p.G532W	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	532	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TCCCACGAACGGGGCCATCTA	0.587													13	17					0.000151284	0.000252355	1	0	T	58208274	T	T	58208274	3	4	166	1	0	0	0	0	1	0	0	0	11566	1116	39	3	1596	3	PCDH17	13	58208274	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5531966	58208274	56961604	780	31108											
PCDH17	27253	broad.mit.edu	37	chr13	58208540	58208540	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacagcgacttcggcgagagCgggcgtctcacctacgagat	9	6	14	12	6	1	2	1	0	1	2	3	6	1	2	1	2	3	0	1	2	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:58208540C>A	uc001vhq.1	+	1	2752	c.1860C>A	c.(1858-1860)AGC>AGA	p.S620R	PCDH17_uc010aec.1_Missense_Mutation_p.S620R	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	620	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TCGGCGAGAGCGGGCGTCTCA	0.662													28	34					1.77063e-15	3.85176e-15	1	0	A	58208540	A	A	58208540	3	1	166	1	0	0	0	0	1	0	0	0	11566	767	27	3	1862	3	PCDH17	13	58208540	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	266	58208540	56961338	781	31109											
UGGT2	55757	broad.mit.edu	37	chr13	96599374	96599374	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagagagcaactccagcatCatttgctccatcaacttcat	12	10	5	14	0	3	1	3	0	0	1	5	2	5	1	3	0	5	3	3	0	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:96599374C>T	uc001vmt.2	-	15	1764	c.1594G>A	c.(1594-1596)GAT>AAT	p.D532N		NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	532					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						ACTCCAGCATCATTTGCTCCA	0.343													23	33					0	0	0	0	T	96599374	T	T	96599374	3	4	166	1	0	0	0	0	1	0	0	0	17010	826	29	2	3056	2	UGGT2	13	96599374	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	38390834	96599374	18570504	782	31110											
FAM155A	728215	broad.mit.edu	37	chr13	108518792	108518793	+	Missense_Mutation	DNP	CA	AG	AG																															aaccacaagtgatcagagagCaggactgtgaaaaacaagag																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:108518792_108518793CA>AG	uc001vql.2	-	1	668_669	c.152_153TG>CT	c.(151-153)CTG>CCT	p.L51P		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	51	Helical; (Potential).					integral to membrane	binding			skin(1)	1						GATCAGAGAGCAGGACTGTGAA	0.455													39	80					0	0	0	0	AG	108518793	AG	AG	108518792	3	1	166	1	0	0	0	0	1	0	0	0	5493	697	25	4	1235	4	FAM155A	13	108518792	Missense_Mutation	DNP	CA	TCGA-CR-7402-01A-11D-2012-08	11919418	108518792	6651086	783	31111											
F7	2155	broad.mit.edu	37	chr13	113770072	113770072	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctcctgtcggtgccacgagGggtactctctgctggcagac	5	9	14	13	2	1	1	0	0	1	1	4	2	2	1	2	4	3	4	2	4	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:113770072G>T	uc001vsv.2	+	6	580	c.529G>T	c.(529-531)GGG>TGG	p.G177W	F7_uc010agp.1_Missense_Mutation_p.G170W|F7_uc001vsw.2_Missense_Mutation_p.G155W|F7_uc010tjt.1_Missense_Mutation_p.G108W	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	177	EGF-like 2.		G -> R (in FA7D).		anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	GTGCCACGAGGGGTACTCTCT	0.602													7	24					0.00198382	0.00322679	1	0	T	113770072	T	T	113770072	3	4	166	1	0	0	0	0	1	0	0	0	5374	1232	43	4	551	4	F7	13	113770072	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5251280	113770072	1399806	784	31112											
POTEG	404785	broad.mit.edu	37	chr14	19553561	19553561	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtgggcacttctggagacCacgacgattctgctatgaag	10	9	12	10	3	2	2	0	1	2	1	2	5	2	2	1	2	1	2	1	2	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:19553561C>G	uc001vuz.1	+	1	197	c.145C>G	c.(145-147)CAC>GAC	p.H49D	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	49										ovary(1)	1						TTCTGGAGACCACGACGATTC	0.607													30	550					0	0	0	0	G	19553561	G	G	19553561	3	3	166	1	0	0	0	0	1	0	0	0	12321	594	21	4	147	4	POTEG	14	19553561	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08		19553561	87795979	785	31113											
OR4Q3	441669	broad.mit.edu	37	chr14	20216334	20216334	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacctgacagtggtcagcCtgatcttcgtgccatgcgta	7	11	10	13	2	3	2	2	2	1	0	4	2	3	2	3	1	3	1	3	1	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20216334C>A	uc010tkt.1	+	1	748	c.748C>A	c.(748-750)CTG>ATG	p.L250M		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGTGGTCAGCCTGATCTTCGT	0.453													35	226					1.96642e-18	4.48682e-18	1	0	A	20216334	A	A	20216334	3	1	166	1	0	0	0	0	1	0	0	0	11135	680	24	4	750	4	OR4Q3	14	20216334	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	662773	20216334	87133206	786	31114											
OR4M1	441670	broad.mit.edu	37	chr14	20248502	20248502	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggaaactgcaaattacacCaaggtgacagaatttgttct	15	11	8	7	0	1	2	0	1	1	1	1	3	1	3	1	2	3	2	1	2	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20248502C>A	uc010tku.1	+	1	21	c.21C>A	c.(19-21)ACC>ACA	p.T7T		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAAATTACACCAAGGTGACAG	0.338													26	178					7.16444e-05	0.000120535	1	0	A	20248502	A	A	20248502	2	1	166	1	0	0	0	0	0	0	0	1	11129	581	21	4		4	OR4M1	14	20248502	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	32168	20248502	87101038	787	31115											
OR4M1	441670	broad.mit.edu	37	chr14	20248683	20248683	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgttggctaatctggccCtccttgatatttggtactct	5	17	8	11	0	2	1	0	1	2	0	4	1	4	1	3	3	1	3	3	3	3	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20248683C>A	uc010tku.1	+	1	202	c.202C>A	c.(202-204)CTC>ATC	p.L68I		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TAATCTGGCCCTCCTTGATAT	0.423													66	532					3.07281e-33	7.69185e-33	1	0	A	20248683	A	A	20248683	3	1	166	1	0	0	0	0	1	0	0	0	11129	681	24	4	204	4	OR4M1	14	20248683	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	181	20248683	87100857	788	31116											
OR4K2	390431	broad.mit.edu	37	chr14	20345255	20345255	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtctgtgttttataccAtctttactcccactctgaac	7	18	4	12	0	4	1	0	1	4	0	5	1	5	1	2	0	3	1	2	0	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20345255A>T	uc001vwh.1	+	1	829	c.829A>T	c.(829-831)ATC>TTC	p.I277F		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTTTTATACCATCTTTACTCC	0.358													23	119					0	0	0	0	T	20345255	T	T	20345255	3	4	166	1	0	0	0	0	1	0	0	0	11126	217	8	5	831	5	OR4K2	14	20345255	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	96572	20345255	87004285	789	31117											
OR4K14	122740	broad.mit.edu	37	chr14	20482729	20482729	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggagcagaaaacagctcaaGgaaagcaacccactgtctga	17	4	10	10	0	2	2	1	1	1	1	2	4	2	4	1	2	5	3	1	2	5	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20482729G>C	uc010tky.1	-	1	624	c.624C>G	c.(622-624)TCC>TCG	p.S208S		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AACAGCTCAAGGAAAGCAACC	0.502													13	32					0	0	0	0	C	20482729	C	C	20482729	2	2	166	1	0	0	0	0	0	0	0	1	11123	987	35	4		4	OR4K14	14	20482729	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	137474	20482729	86866811	790	31118											
OR4K13	390433	broad.mit.edu	37	chr14	20502160	20502160	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agacgtagataaagacacacGgagcaaagaacagagtcaca	20	3	10	8	2	1	5	1	0	0	5	1	6	1	6	0	1	2	2	0	1	5	2	rs150686832	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20502160G>T	uc010tkz.1	-	1	758	c.758C>A	c.(757-759)CCG>CAG	p.P253Q		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AAAGACACACGGAGCAAAGAA	0.413													22	46					2.89027e-11	5.72215e-11	1	0	T	20502160	T	T	20502160	3	4	166	1	0	0	0	0	1	0	0	0	11122	1116	39	3	158	3	OR4K13	14	20502160	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	19431	20502160	86847380	791	31119											
OR4L1	122742	broad.mit.edu	37	chr14	20528986	20528986	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttttatctatgtttggccAttcagtagtttggcaagcaa	10	17	8	6	0	2	0	1	0	1	0	2	0	2	0	1	2	1	5	1	2	5	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20528986A>G	uc001vwn.1	+	1	783	c.783A>G	c.(781-783)CCA>CCG	p.P261P		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ATGTTTGGCCATTCAGTAGTT	0.403													23	87					0	0	0	0	G	20528986	G	G	20528986	2	3	166	1	0	0	0	0	0	0	0	1	11128	204	8	5		5	OR4L1	14	20528986	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	26826	20528986	86820554	792	31120											
OR11G2	390439	broad.mit.edu	37	chr14	20666322	20666322	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgggagaagaaaggctttCtccacctgtgggtctcacct	8	10	12	11	0	2	2	1	0	2	2	4	3	2	2	3	3	0	2	3	3	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20666322C>T	uc010tlb.1	+	1	828	c.828C>T	c.(826-828)TTC>TTT	p.F276F		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	276	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GAAAGGCTTTCTCCACCTGTG	0.443													57	145					0	0	0	0	T	20666322	T	T	20666322	2	4	166	1	0	0	0	0	0	0	0	1	10979	912	32	2		2	OR11G2	14	20666322	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	137336	20666322	86683218	793	31121											
OR11H6	122748	broad.mit.edu	37	chr14	20692320	20692320	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtcgtccattacactaccCctccatcatgactgggaagt	9	11	7	14	1	1	1	1	1	0	0	4	2	3	2	4	1	2	0	4	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20692320C>A	uc010tlc.1	+	1	452	c.452C>A	c.(451-453)CCC>CAC	p.P151H		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	151	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TTACACTACCCCTCCATCATG	0.423													40	77					5.71845e-15	1.22897e-14	1	0	A	20692320	A	A	20692320	3	1	166	1	0	0	0	0	1	0	0	0	10983	623	22	4	454	4	OR11H6	14	20692320	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	25998	20692320	86657220	794	31122											
OR6S1	341799	broad.mit.edu	37	chr14	21109748	21109748	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagattcaggagatagacaaGaagaaacacagaaaataatt	22	6	8	5	0	1	6	1	0	0	6	1	7	1	6	0	1	1	0	0	1	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:21109748G>T	uc001vxv.1	-	1	103	c.103C>A	c.(103-105)CTT>ATT	p.L35I		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		AGATAGACAAGAAGAAACACA	0.478													37	93					2.47316e-13	5.08645e-13	1	0	T	21109748	T	T	21109748	3	4	166	1	0	0	0	0	1	0	0	0	11263	942	33	2	896	2	OR6S1	14	21109748	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	417428	21109748	86239792	795	31123											
LRFN5	145581	broad.mit.edu	37	chr14	42355978	42355978	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgttccaccaaacattgaCagaagaactgtggaactgcg	13	10	9	9	1	0	3	0	1	0	2	1	4	1	4	2	1	4	1	2	1	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:42355978C>A	uc001wvm.2	+	3	1348	c.150C>A	c.(148-150)GAC>GAA	p.D50E	LRFN5_uc010ana.2_Missense_Mutation_p.D50E	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	50	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CAAACATTGACAGAAGAACTG	0.413										HNSCC(30;0.082)			15	23					1.49906e-05	2.56832e-05	1	0	A	42355978	A	A	42355978	3	1	166	1	0	0	0	0	1	0	0	0	8991	477	17	4	152	4	LRFN5	14	42355978	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	21246230	42355978	64993562	796	31124											
FANCM	57697	broad.mit.edu	37	chr14	45669148	45669148	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctatagatatattcactaTgtatttgacatacaaatgtt	15	17	4	5	0	2	2	1	1	1	1	2	2	2	2	0	0	1	2	0	0	8	10			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:45669148T>C	uc001wwd.3	+	23	6183	c.6084T>C	c.(6082-6084)TAT>TAC	p.Y2028Y	FANCM_uc010anf.2_Silent_p.Y2002Y|FANCM_uc001wwe.3_Silent_p.Y1564Y|FANCM_uc010ang.2_Silent_p.Y1277Y	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	2028	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						ATATTCACTATGTATTTGACA	0.338								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				23	56					0	0	0	0	C	45669148	C	C	45669148	2	2	166	1	0	0	0	0	0	0	0	1	5703	1471	51	5		5	FANCM	14	45669148	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	3313170	45669148	61680392	797	31125											
SDCCAG1	9147	broad.mit.edu	37	chr14	50312932	50312932	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatctacaattctatccaCaccaagctgttttgcactga	14	12	4	11	0	2	1	0	1	2	0	3	1	3	1	2	0	3	3	2	0	6	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:50312932C>A	uc001wxc.2	-	4	351	c.283G>T	c.(283-285)GTG>TTG	p.V95L	SDCCAG1_uc010anj.1_Missense_Mutation_p.V95L|SDCCAG1_uc010tqi.1_Missense_Mutation_p.V95L|SDCCAG1_uc001wxe.2_Intron|SDCCAG1_uc010anq.1_5'UTR	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	95						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		ATTCTATCCACACCAAGCTGT	0.358													13	32					2.32078e-09	4.43347e-09	1	0	A	50312932	A	A	50312932	3	1	166	1	0	0	0	0	1	0	0	0	14022	478	17	4	3067	4	SDCCAG1	14	50312932	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4643784	50312932	57036608	798	31126											
NIN	51199	broad.mit.edu	37	chr14	51288662	51288662	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctccaagctcaacatgTggcaaaggtcggtgagttcc	9	9	10	13	1	1	1	1	1	0	0	5	1	4	1	4	3	2	3	4	3	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:51288662T>G	uc001wym.2	-	3	304	c.113A>C	c.(112-114)CAC>CCC	p.H38P	NIN_uc001wyi.2_Missense_Mutation_p.H38P|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.H38P|NIN_uc010tqp.1_Missense_Mutation_p.H44P|NIN_uc001wyo.2_Missense_Mutation_p.H38P|NIN_uc001wyp.1_5'UTR	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	38	EF-hand 1.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GCTCAACATGTGGCAAAGGTC	0.587			T	PDGFRB	MPD								67	244					0	0	0	0	G	51288662	G	G	51288662	3	3	166	1	0	0	0	0	1	0	0	0	10471	1696	59	5	6552	5	NIN	14	51288662	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	975730	51288662	56060878	799	31127											
PYGL	5836	broad.mit.edu	37	chr14	51381466	51381466	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgcagagtaggagccagcGccttggagtgatcccattgg	8	9	15	9	1	0	2	0	1	0	1	1	4	1	4	3	3	3	3	3	3	1	4	rs113993980		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:51381466G>T	uc001wyu.2	-	12	1598	c.1471C>A	c.(1471-1473)CGC>AGC	p.R491S	PYGL_uc010tqq.1_Missense_Mutation_p.R457S|PYGL_uc001wyv.2_Missense_Mutation_p.R165S	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	491					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	AGGAGCCAGCGCCTTGGAGTG	0.498													17	57					2.35188e-11	4.67989e-11	1	0	T	51381466	T	T	51381466	3	4	166	1	0	0	0	0	1	0	0	0	12926	1087	38	3	1108	3	PYGL	14	51381466	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	92804	51381466	55968074	800	31128											
PTGER2	5732	broad.mit.edu	37	chr14	52781592	52781592	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcgcccgagagccgcgcgtGcacctacttcgctttcgcca	5	7	12	17	7	0	1	0	0	0	1	2	2	0	1	4	1	3	2	4	1	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:52781592G>C	uc001wzr.2	+	1	577	c.326G>C	c.(325-327)TGC>TCC	p.C109S		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	109	Extracellular (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	AGCCGCGCGTGCACCTACTTC	0.647													23	67					0	0	0	0	C	52781592	C	C	52781592	3	2	166	1	0	0	0	0	1	0	0	0	12806	1319	46	4	328	4	PTGER2	14	52781592	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1400126	52781592	54567948	801	31129											
SLC35F4	341880	broad.mit.edu	37	chr14	58056150	58056150	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagatgcccttcagaaccAtggacgtgcaggacaggcag	11	5	12	13	1	1	2	1	0	0	2	1	4	1	4	3	3	3	2	3	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:58056150A>G	uc001xdb.1	-	3	479	c.479T>C	c.(478-480)ATG>ACG	p.M160T	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.M1T	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						CTTCAGAACCATGGACGTGCA	0.443													11	29					0	0	0	0	G	58056150	G	G	58056150	3	3	166	1	0	0	0	0	1	0	0	0	14655	217	8	5	1110	5	SLC35F4	14	58056150	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	5274558	58056150	49293390	802	31130											
DHRS7	51635	broad.mit.edu	37	chr14	60622799	60622799	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aactcctagtttagacaactGgtaagccagctcctcaccaa	13	9	6	13	0	1	1	1	0	0	1	3	1	3	1	4	1	4	3	4	1	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:60622799G>T	uc001xes.2	-	2	389	c.205C>A	c.(205-207)CAG>AAG	p.Q69K	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Missense_Mutation_p.Q19K|DHRS7_uc001xeu.2_Missense_Mutation_p.Q69K	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	69	NAD (By similarity).						binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		TTAGACAACTGGTAAGCCAGC	0.478													23	67					2.89027e-11	5.72215e-11	1	0	T	60622799	T	T	60622799	3	4	166	1	0	0	0	0	1	0	0	0	4517	1357	47	4	838	4	DHRS7	14	60622799	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2566649	60622799	46726741	803	31131											
SGPP1	81537	broad.mit.edu	37	chr14	64152979	64152979	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atattgaagattttgcaggcTaaaggaatggtgatcttttt	12	16	10	3	0	1	3	0	2	1	1	1	4	1	4	0	3	1	2	0	3	5	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:64152979T>A	uc001xgj.2	-	3	1264	c.1170A>T	c.(1168-1170)TTA>TTT	p.L390F		NM_030791	NP_110418	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	390						endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		TTTTGCAGGCTAAAGGAATGG	0.373													23	87					0	0	0	0	A	64152979	A	A	64152979	3	1	166	1	0	0	0	0	1	0	0	0	14284	1519	53	5	159	5	SGPP1	14	64152979	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	3530180	64152979	43196561	804	31132											
ZFP36L1	677	broad.mit.edu	37	chr14	69257126	69257126	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagtgcctccgagggaagccCccaccagcaggggtgcccac	8	3	14	16	1	0	0	0	0	0	0	1	3	1	1	6	3	4	1	6	3	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:69257126C>A	uc001xkh.1	-	2	271	c.141G>T	c.(139-141)GGG>GGT	p.G47G	ZFP36L1_uc001xki.1_Silent_p.G47G	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	47					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GAGGGAAGCCCCCACCAGCAG	0.612											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	22					0.000274275	0.000453271	1	0	A	69257126	A	A	69257126	2	1	166	1	0	0	0	0	0	0	0	1	17713	610	22	4		4	ZFP36L1	14	69257126	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5104147	69257126	38092414	805	31133											
PCNX	22990	broad.mit.edu	37	chr14	71555910	71555910	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttatctccaatcttaacagtAatttagagtcattcctctat	12	17	3	9	0	4	1	1	0	3	1	6	1	5	1	2	0	1	1	2	0	6	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:71555910A>T	uc001xmo.2	+	30	5886	c.5440A>T	c.(5440-5442)AAT>TAT	p.N1814Y	PCNX_uc010are.1_Missense_Mutation_p.N1703Y|PCNX_uc010arf.1_Missense_Mutation_p.N602Y	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1814						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TCTTAACAGTAATTTAGAGTC	0.274													14	53					0	0	0	0	T	71555910	T	T	71555910	3	4	166	1	0	0	0	0	1	0	0	0	11645	376	13	5	5558	5	PCNX	14	71555910	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2298784	71555910	35793630	806	31134											
ABCD4	5826	broad.mit.edu	37	chr14	74759551	74759551	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aactcaggatgctgcccagaTagtcaaaggtgttgatgccg	11	9	12	9	1	2	2	2	1	0	1	2	3	2	3	2	2	4	2	2	2	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:74759551T>C	uc001xpr.2	-	9	988	c.836A>G	c.(835-837)TAT>TGT	p.Y279C	ABCD4_uc001xps.2_Missense_Mutation_p.Y120C|ABCD4_uc001xpt.2_Missense_Mutation_p.Y120C|ABCD4_uc010tur.1_Missense_Mutation_p.Y175C|ABCD4_uc001xpu.2_Missense_Mutation_p.Y16C|ABCD4_uc001xpv.2_RNA	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	279	ABC transmembrane type-1.|Helical; (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		GCTGCCCAGATAGTCAAAGGT	0.537													22	47					0	0	0	0	C	74759551	C	C	74759551	3	2	166	1	0	0	0	0	1	0	0	0	63	1406	49	5	1028	5	ABCD4	14	74759551	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	3203641	74759551	32589989	807	31135											
LTBP2	4053	broad.mit.edu	37	chr14	74969972	74969972	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggctccaggcctcgccgTcctggcagcagcattccgtg	4	8	13	16	3	0	0	0	0	0	0	4	0	3	0	5	3	2	5	5	3	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:74969972T>A	uc001xqa.2	-	33	5225	c.4838A>T	c.(4837-4839)GAC>GTC	p.D1613V		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1613	TB 4.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGCCTCGCCGTCCTGGCAGCA	0.637													19	35					0	0	0	0	A	74969972	A	A	74969972	3	1	166	1	0	0	0	0	1	0	0	0	9124	1667	58	5	643	5	LTBP2	14	74969972	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	210421	74969972	32379568	808	31136											
FLRT2	23768	broad.mit.edu	37	chr14	86087868	86087868	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtacttcagaaatgggcctaCagaccacaaagtggcccagc	13	6	10	12	0	1	2	1	0	0	2	1	2	1	2	3	2	3	1	3	2	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:86087868C>T	uc001xvr.2	+	2	777	c.10C>T	c.(10-12)CAG>TAG	p.Q4*	FLRT2_uc010atd.2_Nonsense_Mutation_p.Q4*	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	4					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		AATGGGCCTACAGACCACAAA	0.443													24	73					0	0	0	0	T	86087868	T	T	86087868	4	4	166	1	0	0	0	0	0	1	0	0	5971	479	17	4	12	4	FLRT2	14	86087868	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	11117896	86087868	21261672	809	31137											
FLRT2	23768	broad.mit.edu	37	chr14	86088278	86088278	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagcttgaagagctgcacctGgatgacaactccatatccac	13	8	8	12	0	0	3	0	2	0	1	2	4	2	4	3	1	4	3	3	1	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:86088278G>C	uc001xvr.2	+	2	1187	c.420G>C	c.(418-420)CTG>CTC	p.L140L	FLRT2_uc010atd.2_Silent_p.L140L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	140	LRR 4.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		AGCTGCACCTGGATGACAACT	0.488													16	55					0	0	0	0	C	86088278	C	C	86088278	2	2	166	1	0	0	0	0	0	0	0	1	5971	1335	47	4		4	FLRT2	14	86088278	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	410	86088278	21261262	810	31138											
SMEK1	55671	broad.mit.edu	37	chr14	91948115	91948115	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttaaacttggctgtttttgtTagaaattccctgtgttttcg	7	20	8	6	1	0	1	0	0	0	1	2	1	1	1	1	1	1	4	1	1	4	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:91948115T>A	uc001xzn.2	-	4	1542	c.720A>T	c.(718-720)CTA>CTT	p.L240L	SMEK1_uc001xzm.2_Silent_p.L240L|SMEK1_uc001xzo.2_Silent_p.L240L|SMEK1_uc010atz.2_Intron|SMEK1_uc001xzp.1_RNA|SMEK1_uc001xzq.1_Silent_p.L116L	NM_032560	NP_115949	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1	240						microtubule organizing center|nucleus	protein binding				0		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		CTGTTTTTGTTAGAAATTCCC	0.338													20	54					0	0	0	0	A	91948115	A	A	91948115	2	1	166	1	0	0	0	0	0	0	0	1	14857	1741	61	5		5	SMEK1	14	91948115	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5859837	91948115	15401425	811	31139											
RIN3	79890	broad.mit.edu	37	chr14	93118666	93118666	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcagacggccctgaggaCacgccccgggagagcacgga	10	2	14	15	4	1	3	1	1	0	2	1	6	1	5	4	4	1	1	4	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:93118666C>G	uc001yap.2	+	6	1424	c.1272C>G	c.(1270-1272)GAC>GAG	p.D424E	RIN3_uc010auk.2_Missense_Mutation_p.D86E|RIN3_uc001yaq.2_Missense_Mutation_p.D349E|RIN3_uc001yar.1_Missense_Mutation_p.D86E|RIN3_uc001yas.1_Missense_Mutation_p.D86E	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	424	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				GCCCTGAGGACACGCCCCGGG	0.642													22	50					0	0	0	0	G	93118666	G	G	93118666	3	3	166	1	0	0	0	0	1	0	0	0	13438	477	17	4	1294	4	RIN3	14	93118666	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1170551	93118666	14230874	812	31140											
KIAA1409	57578	broad.mit.edu	37	chr14	94038416	94038416	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gataatcagttaaaagaattCagggaagtattaaggtgggt	16	11	12	2	0	2	1	2	0	0	1	2	3	2	2	0	3	0	2	0	3	7	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:94038416C>G	uc001ybv.1	+	12	1484	c.1401C>G	c.(1399-1401)TTC>TTG	p.F467L	KIAA1409_uc001ybs.1_Missense_Mutation_p.F467L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	644						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TAAAAGAATTCAGGGAAGTAT	0.289													12	40					0	0	0	0	G	94038416	G	G	94038416	3	3	166	1	0	0	0	0	1	0	0	0	8269	825	29	2	1447	2	KIAA1409	14	94038416	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	919750	94038416	13311124	813	31141											
PRIMA1	145270	broad.mit.edu	37	chr14	94187840	94187840	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgttgctctgcgaagcacTcatgggatactcagcaacgc	9	11	10	11	2	3	0	2	0	1	0	3	2	3	1	0	1	6	4	0	1	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:94187840T>G	uc001ybw.1	-	5	454	c.412A>C	c.(412-414)AGT>CGT	p.S138R	PRIMA1_uc001ybx.1_RNA	NM_178013	NP_821092	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1 precursor	138	Cytoplasmic (Potential).				neurotransmitter catabolic process	cell junction|integral to membrane|synapse				large_intestine(1)|skin(1)	2		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		TGCGAAGCACTCATGGGATAC	0.587													14	36					0	0	0	0	G	94187840	G	G	94187840	3	3	166	1	0	0	0	0	1	0	0	0	12554	1551	54	5	53	5	PRIMA1	14	94187840	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	149424	94187840	13161700	814	31142											
PPP4R4	57718	broad.mit.edu	37	chr14	94711942	94711942	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtactagatgctcttataGatcatcttccagaaatcttg	12	14	7	8	0	4	3	1	0	3	3	5	3	5	3	1	1	2	2	1	1	5	6	rs143566515		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:94711942G>T	uc001ycs.1	+	13	1517	c.1363G>T	c.(1363-1365)GAT>TAT	p.D455Y		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	455						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TGCTCTTATAGATCATCTTCC	0.313													24	66					3.5997e-14	7.58646e-14	1	0	T	94711942	T	T	94711942	3	4	166	1	0	0	0	0	1	0	0	0	12465	942	33	2	1486	2	PPP4R4	14	94711942	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	524102	94711942	12637598	815	31143											
SERPINA4	5267	broad.mit.edu	37	chr14	95033445	95033445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcatgacagatacttgccctGctcggtgctacggatggatt	8	12	11	10	2	1	2	1	1	0	1	2	4	1	4	1	3	5	2	1	3	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95033445G>A	uc001ydk.2	+	3	854	c.788G>A	c.(787-789)TGC>TAC	p.C263Y	SERPINA4_uc010avd.2_Missense_Mutation_p.C300Y|SERPINA4_uc001ydl.2_Missense_Mutation_p.C263Y	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	263					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		TACTTGCCCTGCTCGGTGCTA	0.493													15	44					0	0	0	0	A	95033445	A	A	95033445	3	1	166	1	0	0	0	0	1	0	0	0	14156	1319	46	4	794	4	SERPINA4	14	95033445	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	321503	95033445	12316095	816	31144											
SERPINA5	5104	broad.mit.edu	37	chr14	95058512	95058512	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagaggctagtgttcaacaGgccctttctgatgttcattg	8	14	10	9	0	4	2	3	1	1	1	4	2	4	2	1	2	1	3	1	2	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95058512G>T	uc001ydm.2	+	6	1367	c.1157G>T	c.(1156-1158)AGG>ATG	p.R386M	SERPINA3_uc001ydo.3_Intron	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	386					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	GTGTTCAACAGGCCCTTTCTG	0.557													135	323					8.32301e-65	2.12965e-64	1	0	T	95058512	T	T	95058512	3	4	166	1	0	0	0	0	1	0	0	0	14157	1000	35	4	1171	4	SERPINA5	14	95058512	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	25067	95058512	12291028	817	31145											
GSC	145258	broad.mit.edu	37	chr14	95234860	95234861	+	Nonsense_Mutation	DNP	CC	AA	AA																															gtccaaatcgcttttaccttCctcttccctcttctccggtg																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95234860_95234861CC>AA	uc001ydu.2	-	3	888_889	c.741_742GG>TT	c.(739-744)GAGGAA>GATTAA	p.247_248EE>D*		NM_173849	NP_776248	P56915	GSC_HUMAN	goosecoid	247_248					gastrulation|middle ear morphogenesis		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(154;0.0896)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.202)|Epithelial(152;0.239)		CTTTTACCTTCCTCTTCCCTCT	0.559													40	104					0	0	0	0	AA	95234861	AA	AA	95234860	4	1	166	1	0	0	0	0	0	1	0	0	6853	864	30	2	35	2	GSC	14	95234860	Nonsense_Mutation	DNP	CC	TCGA-CR-7402-01A-11D-2012-08	176348	95234860	12114680	818	31146											
DICER1	23405	broad.mit.edu	37	chr14	95582111	95582111	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatccatgacaggatcaatGtcagtctcaccagtatcaac	13	10	6	12	0	5	1	5	1	1	0	7	2	6	2	2	1	1	1	2	1	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95582111G>T	uc001ydw.2	-	12	1982	c.1800C>A	c.(1798-1800)GAC>GAA	p.D600E	DICER1_uc001ydv.2_Missense_Mutation_p.D590E|DICER1_uc001ydx.2_Missense_Mutation_p.D600E	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	600	Helicase C-terminal.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CAGGATCAATGTCAGTCTCAC	0.433			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				24	44					2.39556e-15	5.17104e-15	1	0	T	95582111	T	T	95582111	3	4	166	1	0	0	0	0	1	0	0	0	4543	1368	48	4	4036	4	DICER1	14	95582111	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	347251	95582111	11767429	819	31147											
NDN	4692	broad.mit.edu	37	chr15	23931753	23931753	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacggcgctctctctggcGccgcggcccttcacgtagat	5	8	12	16	6	3	2	1	0	2	2	4	2	3	2	2	3	0	2	2	3	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:23931753G>T	uc001ywk.2	-	1	698	c.612C>A	c.(610-612)GGC>GGA	p.G204G		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	204	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		TCTCTCTGGCGCCGCGGCCCT	0.657									Prader-Willi_syndrome				10	25					2.17888e-05	3.72003e-05	1	0	T	23931753	T	T	23931753	2	4	166	1	0	0	0	0	0	0	0	1	10301	1074	38	3		3	NDN	15	23931753	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08		23931753	78599639	820	31148											
GABRB3	2562	broad.mit.edu	37	chr15	26806276	26806276	+	Frame_Shift_Del	DEL	C	-	-																															ggggattttgggcaaggtctCccgaaggtgggtgttgatgg																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:26806276delC	uc001zaz.2	-	8	1025	c.883delG	c.(883-885)GAGfs	p.E295fs	GABRB3_uc010uae.1_Frame_Shift_Del_p.E210fs|GABRB3_uc001zba.2_Frame_Shift_Del_p.E295fs|GABRB3_uc001zbb.2_Frame_Shift_Del_p.E351fs	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	295					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGCAAGGTCTCCCGAAGGTGG	0.473													---	---	---								-	26806276	-	-	26806276	7	5	166	1	0	1	0	1	0	0	0	0	6202	864	30	0	546	0	GABRB3	15	26806276	Frame_Shift_Del	DEL	C	TCGA-CR-7402-01A-11D-2012-08	2874523	26806276	75725116	821	31149											
CHRFAM7A	89832	broad.mit.edu	37	chr15	30665184	30665184	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagtctcatggcttacccaCtaggtcccattctccattgg	7	14	7	13	0	2	0	1	0	2	0	5	0	3	0	3	3	1	1	3	3	3	5	rs144150663		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:30665184C>A	uc001zdt.1	-	6	891	c.325G>T	c.(325-327)GTG>TTG	p.V109L	DKFZP434L187_uc001zds.2_RNA|CHRFAM7A_uc001zdu.1_Missense_Mutation_p.V18L|CHRFAM7A_uc010azn.2_Missense_Mutation_p.V18L|CHRFAM7A_uc001zdv.2_RNA	NM_139320	NP_647536	Q494W8	CRFM7_HUMAN	CHRNA7-FAM7A fusion isoform 1	109						integral to membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity			skin(1)	1		all_lung(180;3.42e-11)|Breast(32;0.000153)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		GGCTTACCCACTAGGTCCCAT	0.502													41	84					1.00001e-27	2.45002e-27	1	0	A	30665184	A	A	30665184	3	1	166	1	0	0	0	0	1	0	0	0	3390	565	20	4	933	4	CHRFAM7A	15	30665184	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3858908	30665184	71866208	822	31150											
RYR3	6263	broad.mit.edu	37	chr15	34040373	34040373	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaaaaccatgctggctgtggGctggactgtggagaggacca	10	7	16	8	0	0	1	0	0	0	1	0	5	0	3	2	5	2	3	2	5	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:34040373G>A	uc001zhi.2	+	54	8118	c.8048G>A	c.(8047-8049)GGC>GAC	p.G2683D	RYR3_uc010bar.2_Missense_Mutation_p.G2683D	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2683	3.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGGCTGTGGGCTGGACTGTG	0.522													22	28					0	0	0	0	A	34040373	A	A	34040373	3	1	166	1	0	0	0	0	1	0	0	0	13835	1203	42	4	8262	4	RYR3	15	34040373	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3375189	34040373	68491019	823	31151											
PLA2G4F	255189	broad.mit.edu	37	chr15	42442599	42442599	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccacagaacactgttccTcctggcctaggggcagagag	9	6	14	12	0	0	2	0	0	0	2	2	3	2	2	4	4	1	2	4	4	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:42442599T>G	uc001zoz.2	-	9	920	c.857A>C	c.(856-858)GAG>GCG	p.E286A	PLA2G4F_uc001zoy.2_5'Flank|PLA2G4F_uc010bcr.2_Missense_Mutation_p.E37A|PLA2G4F_uc001zpa.2_Missense_Mutation_p.E37A|PLA2G4F_uc010bcs.2_Missense_Mutation_p.E73A	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	286					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		ACACTGTTCCTCCTGGCCTAG	0.627													9	14					0	0	0	0	G	42442599	G	G	42442599	3	3	166	1	0	0	0	0	1	0	0	0	12061	1551	54	5	1740	5	PLA2G4F	15	42442599	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	8402226	42442599	60088793	824	31152											
SPG11	80208	broad.mit.edu	37	chr15	44888469	44888469	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatcgctgtccattttggAggtgggcactgagggcaagt	7	12	15	7	1	0	2	0	2	0	0	2	3	1	3	1	4	0	3	1	4	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:44888469A>G	uc001ztx.2	-	25	4277	c.4246T>C	c.(4246-4248)TCC>CCC	p.S1416P	SPG11_uc010ueh.1_Missense_Mutation_p.S1416P|SPG11_uc010uei.1_Missense_Mutation_p.S1416P|SPG11_uc001zty.1_Missense_Mutation_p.S145P	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1416	Cytoplasmic (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TCCATTTTGGAGGTGGGCACT	0.463													3	93					0	0	0	0	G	44888469	G	G	44888469	3	3	166	1	0	0	0	0	1	0	0	0	15107	304	11	5	3149	5	SPG11	15	44888469	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2445870	44888469	57642923	825	31153											
SLC12A1	6557	broad.mit.edu	37	chr15	48577336	48577336	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attagaacaggagagactagCattggaagcgactatcaaag	17	7	11	6	1	1	2	1	0	0	2	1	6	1	4	0	2	3	1	0	2	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:48577336C>A	uc001zwn.3	+	21	2735	c.2519C>A	c.(2518-2520)GCA>GAA	p.A840E	SLC12A1_uc010uew.1_Missense_Mutation_p.A646E|SLC12A1_uc001zwq.3_Missense_Mutation_p.A611E|SLC12A1_uc001zwr.3_Missense_Mutation_p.A567E	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	840	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GAGAGACTAGCATTGGAAGCG	0.373													28	43					1.39806e-14	2.98171e-14	1	0	A	48577336	A	A	48577336	3	1	166	1	0	0	0	0	1	0	0	0	14447	710	25	4	2697	4	SLC12A1	15	48577336	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3688867	48577336	53954056	826	31154											
HDC	3067	broad.mit.edu	37	chr15	50534984	50534984	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttgggagatgaggttccCaacccgagggctgggttggg	7	9	18	7	1	0	2	0	1	0	1	1	5	1	2	2	5	1	3	2	5	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:50534984C>A	uc001zxz.2	-	12	1568	c.1462G>T	c.(1462-1464)GGG>TGG	p.G488W	HDC_uc001zxy.2_Missense_Mutation_p.G231W|HDC_uc010uff.1_Missense_Mutation_p.G455W	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	488					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	ATGAGGTTCCCAACCCGAGGG	0.567													16	30					1.5739e-10	3.07255e-10	1	0	A	50534984	A	A	50534984	3	1	166	1	0	0	0	0	1	0	0	0	7054	594	21	4	530	4	HDC	15	50534984	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1957648	50534984	51996408	827	31155											
ITGA11	22801	broad.mit.edu	37	chr15	68650827	68650827	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgggccaatgtaaaactttTtcaggatgttgatgaggaag	12	12	12	5	0	1	2	1	2	0	0	1	4	1	4	1	3	1	2	1	3	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:68650827T>C	uc002ari.2	-	6	656	c.569A>G	c.(568-570)AAA>AGA	p.K190R	ITGA11_uc010bib.2_Missense_Mutation_p.K190R	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	190	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	GTAAAACTTTTTCAGGATGTT	0.542													6	13					0	0	0	0	C	68650827	C	C	68650827	3	2	166	1	0	0	0	0	1	0	0	0	7913	1841	64	5	3097	5	ITGA11	15	68650827	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	18115843	68650827	33880565	828	31156											
TLE3	7090	broad.mit.edu	37	chr15	70351092	70351092	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcatcttttttcaggctacgGgccttgtccagcccattttc	5	15	8	13	1	2	0	1	0	1	0	4	0	3	0	3	2	2	2	3	2	1	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:70351092G>A	uc002asm.2	-	11	1947	c.828C>T	c.(826-828)GCC>GCT	p.A276A	TLE3_uc002ask.2_Silent_p.A220A|TLE3_uc002asl.2_Silent_p.A281A|TLE3_uc010ukd.1_Silent_p.A269A|TLE3_uc010bik.1_Intron|TLE3_uc010bil.1_Silent_p.A276A|TLE3_uc002asn.2_Silent_p.A276A|TLE3_uc002asp.2_Silent_p.A276A|TLE3_uc002aso.2_Silent_p.A276A	NM_005078	NP_005069	Q04726	TLE3_HUMAN	transducin-like enhancer protein 3 isoform a	276	Pro/Ser-rich.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|protein binding			lung(2)	2						TCAGGCTACGGGCCTTGTCCA	0.582													5	2					0	0	0	0	A	70351092	A	A	70351092	2	1	166	1	0	0	0	0	0	0	0	1	16006	1219	43	4		4	TLE3	15	70351092	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1700265	70351092	32180300	829	31157											
STRA6	64220	broad.mit.edu	37	chr15	74490147	74490147	+	Frame_Shift_Del	DEL	G	-	-																															ggtggtatgctggtgtggcaGgagggcacttccctgcagag																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:74490147delG	uc002axk.2	-	3	308	c.126delC	c.(124-126)TCCfs	p.S42fs	STRA6_uc002axi.2_5'Flank|STRA6_uc010ulh.1_Frame_Shift_Del_p.S80fs|STRA6_uc002axj.2_Frame_Shift_Del_p.S81fs|STRA6_uc010bji.2_Frame_Shift_Del_p.S42fs|STRA6_uc002axl.2_5'UTR|STRA6_uc002axm.2_Frame_Shift_Del_p.S42fs|STRA6_uc002axn.2_Frame_Shift_Del_p.S42fs|STRA6_uc010uli.1_Frame_Shift_Del_p.S79fs|STRA6_uc010bjj.1_RNA|STRA6_uc010bjk.2_Frame_Shift_Del_p.S42fs	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	42	Extracellular (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						TGGTGTGGCAGGAGGGCACTT	0.622													---	---	---								-	74490147	-	-	74490147	7	5	166	1	0	1	0	1	0	0	0	0	15388	987	35	0	1995	0	STRA6	15	74490147	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	4139055	74490147	28041245	830	31158											
UBE2Q2	92912	broad.mit.edu	37	chr15	76171514	76171514	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcatagaatatattttgctTaacttctcttttaaggtaag	12	17	7	5	0	1	1	0	0	1	1	2	1	1	1	0	2	2	3	0	2	7	10			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:76171514T>G	uc002bbg.2	+	8	1196	c.810T>G	c.(808-810)CTT>CTG	p.L270L	UBE2Q2_uc002bbh.2_Silent_p.L235L|UBE2Q2_uc010umn.1_Silent_p.L254L|UBE2Q2_uc002bbi.2_Silent_p.L151L	NM_173469	NP_775740	Q8WVN8	UB2Q2_HUMAN	ubiquitin-conjugating enzyme E2Q 2 isoform 1	270					protein K48-linked ubiquitination	cytoplasm	ATP binding|ubiquitin-protein ligase activity			ovary(2)	2						ATATTTTGCTTAACTTCTCTT	0.219													12	20					0	0	0	0	G	76171514	G	G	76171514	2	3	166	1	0	0	0	0	0	0	0	1	16938	1741	61	5		5	UBE2Q2	15	76171514	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1681367	76171514	26359878	831	31159											
ACAN	176	broad.mit.edu	37	chr15	89401765	89401765	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcattctggatttctggaCctaagtgggctgcagtccgg	7	11	14	9	1	2	0	0	0	2	0	3	3	3	2	2	4	2	3	2	4	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:89401765C>A	uc010upo.1	+	12	6323	c.5949C>A	c.(5947-5949)GAC>GAA	p.D1983E	ACAN_uc010upp.1_Missense_Mutation_p.D1983E|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1983					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GATTTCTGGACCTAAGTGGGC	0.542													29	37					1.16021e-09	2.22942e-09	1	0	A	89401765	A	A	89401765	3	1	166	1	0	0	0	0	1	0	0	0	117	506	18	4	5991	4	ACAN	15	89401765	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	13230251	89401765	13129627	832	31160											
MESP2	145873	broad.mit.edu	37	chr15	90320436	90320436	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aggctgtccctggacgcagtCgtccccagagccccggaacc	7	5	12	17	3	0	1	0	0	0	1	3	3	2	3	6	3	2	2	6	3	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:90320436C>G	uc002bon.2	+	1	848	c.848C>G	c.(847-849)TCG>TGG	p.S283W	MESP2_uc010uqa.1_Intron	NM_001039958	NP_001035047	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog	283					Notch signaling pathway	nucleus	DNA binding				0	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			TGGACGCAGTCGTCCCCAGAG	0.647													10	7					0	0	0	0	G	90320436	G	G	90320436	3	3	166	1	0	0	0	0	1	0	0	0	9536	893	31	3	850	3	MESP2	15	90320436	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	918671	90320436	12210956	833	31161											
PCSK6	5046	broad.mit.edu	37	chr15	101872152	101872152	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgagagctccagcatcCgcgagcgggactgatgggca	8	5	17	11	3	0	2	0	2	0	1	2	5	2	3	2	3	3	4	2	3	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:101872152C>T	uc002bwy.2	-	15	2257	c.1943G>A	c.(1942-1944)CGG>CAG	p.R648Q	PCSK6_uc010bpd.2_Missense_Mutation_p.R444Q|PCSK6_uc010bpe.2_Missense_Mutation_p.R648Q|PCSK6_uc002bxa.2_Missense_Mutation_p.R648Q|PCSK6_uc002bxb.2_Missense_Mutation_p.R648Q	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	648					glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTCCAGCATCCGCGAGCGGGA	0.567													12	19					0	0	0	0	T	101872152	T	T	101872152	3	4	166	1	0	0	0	0	1	0	0	0	11658	652	23	1	1231	1	PCSK6	15	101872152	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	11551716	101872152	659240	834	31162											
OR4F6	390648	broad.mit.edu	37	chr15	102346444	102346444	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctgtggccctaatgaattAgatagtttcttttgtgatct	8	19	8	6	0	3	3	0	2	3	1	3	3	3	3	1	1	0	1	1	1	4	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:102346444A>T	uc010utr.1	+	1	522	c.522A>T	c.(520-522)TTA>TTT	p.L174F		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CTAATGAATTAGATAGTTTCT	0.373													48	80					0	0	0	0	T	102346444	T	T	102346444	3	4	166	1	0	0	0	0	1	0	0	0	11120	417	15	5	524	5	OR4F6	15	102346444	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	474292	102346444	184948	835	31163											
TMEM8A	58986	broad.mit.edu	37	chr16	422106	422106	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggcggcagcagcaaggctgCgctcccggccagcaggatgt	7	5	16	13	3	0	0	0	0	0	0	1	1	1	1	2	5	4	6	2	5	1	0	rs150493488		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:422106C>G	uc002cgu.3	-	13	2326	c.2197G>C	c.(2197-2199)GCA>CCA	p.A733P	MRPL28_uc010bqu.1_5'Flank|MRPL28_uc002cgr.1_5'Flank|MRPL28_uc002cgs.1_5'Flank|MRPL28_uc002cgt.1_5'Flank|TMEM8A_uc002cgv.3_Missense_Mutation_p.A540P	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	733	Helical; (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3						AGCAAGGCTGCGCTCCCGGCC	0.607													55	62					0	0	0	0	G	422106	G	G	422106	3	3	166	1	0	0	0	0	1	0	0	0	16280	768	27	3	122	3	TMEM8A	16	422106	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08		422106	89932647	836	31164											
PKD1	5310	broad.mit.edu	37	chr16	2159077	2159077	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaacagccccgcggccaCgggcgtgtaggtgacgtcgc	6	5	14	16	6	0	1	0	1	0	0	2	1	1	1	4	3	2	1	4	3	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2159077C>A	uc002cos.1	-	15	6300	c.6091G>T	c.(6091-6093)GTG>TTG	p.V2031L	PKD1_uc002cot.1_Missense_Mutation_p.V2031L	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2031	PKD 16.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCCGCGGCCACGGGCGTGTAG	0.677													45	48					2.215e-12	4.45681e-12	1	0	A	2159077	A	A	2159077	3	1	166	1	0	0	0	0	1	0	0	0	12018	536	19	3	6948	3	PKD1	16	2159077	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1736971	2159077	88195676	837	31165											
PKD1	5310	broad.mit.edu	37	chr16	2167056	2167056	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccacacgtctaggctccTgggggcgggtgtgggatggc	5	8	18	10	2	1	0	0	0	1	0	3	2	3	1	2	6	0	1	2	6	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2167056T>C	uc002cos.1	-	7	1595	c.1386_splice	c.e7-1	p.R462_splice	PKD1_uc002cot.1_Splice_Site_p.R462_splice	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor						calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TCTAGGCTCCTGGGGGCGGGT	0.522													9	15					0	0	0	0	C	2167056	C	C	2167056	5	2	166	1	0	0	0	0	0	0	1	0	12018	1594	55	5	11687	5	PKD1	16	2167056	Splice_Site	SNP	T	TCGA-CR-7402-01A-11D-2012-08	7979	2167056	88187697	838	31166											
ABCA3	21	broad.mit.edu	37	chr16	2329015	2329015	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agagtgttctccacgcaggcCccgatgtggcgctcagggat	7	8	14	12	3	2	1	1	0	1	1	3	3	2	2	3	3	0	3	3	3	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2329015C>T	uc002cpy.1	-	29	5188	c.4476G>A	c.(4474-4476)GGG>GGA	p.G1492G	ABCA3_uc010bsk.1_Silent_p.G1434G	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1492	ABC transporter 2.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CCACGCAGGCCCCGATGTGGC	0.652													41	104					0	0	0	0	T	2329015	T	T	2329015	2	4	166	1	0	0	0	0	0	0	0	1	33	610	22	4		4	ABCA3	16	2329015	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	161959	2329015	88025738	839	31167											
AMDHD2	51005	broad.mit.edu	37	chr16	2578355	2578355	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccaaccccgccgccctgcGgatcgcccaccgtgcccatc	6	4	8	23	5	0	0	0	0	0	0	2	1	0	1	8	1	3	0	8	1	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2578355G>C	uc002cqq.2	+	7	933	c.836G>C	c.(835-837)CGG>CCG	p.R279P	AMDHD2_uc002cqp.2_Missense_Mutation_p.R279P|AMDHD2_uc010uwc.1_Missense_Mutation_p.R279P|AMDHD2_uc010uwd.1_Missense_Mutation_p.R43P	NM_015944	NP_057028	Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2 isoform 1	279					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			skin(2)|large_intestine(1)|breast(1)	4						GCCGCCCTGCGGATCGCCCAC	0.672													15	68					0	0	0	0	C	2578355	C	C	2578355	3	2	166	1	0	0	0	0	1	0	0	0	568	1116	39	3	862	3	AMDHD2	16	2578355	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	249340	2578355	87776398	840	31168											
MEFV	4210	broad.mit.edu	37	chr16	3306443	3306443	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggccatcttcaccggccTggctctctggatctggctcc	4	11	11	15	1	4	0	1	0	3	0	6	1	5	1	4	5	0	2	4	5	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:3306443T>G	uc002cun.1	-	1	185	c.145A>C	c.(145-147)AGG>CGG	p.R49R		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	49	DAPIN.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	TTCACCGGCCTGGCTCTCTGG	0.602													68	85					0	0	0	0	G	3306443	G	G	3306443	2	3	166	1	0	0	0	0	0	0	0	1	9512	1579	55	5		5	MEFV	16	3306443	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	728088	3306443	87048310	841	31169											
GRIN2A	2903	broad.mit.edu	37	chr16	9923416	9923416	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccatgatcttgctggtggtcCctttaggattctggacaggc	6	13	12	10	0	2	1	0	1	2	0	3	3	3	3	2	5	1	1	2	5	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:9923416C>G	uc002czo.3	-	9	2419	c.1871G>C	c.(1870-1872)GGG>GCG	p.G624A	GRIN2A_uc010uym.1_Missense_Mutation_p.G624A|GRIN2A_uc010uyn.1_Missense_Mutation_p.G467A|GRIN2A_uc002czr.3_Missense_Mutation_p.G624A	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	624	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCTGGTGGTCCCTTTAGGATT	0.493													18	85					0	0	0	0	G	9923416	G	G	9923416	3	3	166	1	0	0	0	0	1	0	0	0	6818	623	22	4	2543	4	GRIN2A	16	9923416	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	6616973	9923416	80431337	842	31170											
CIITA	4261	broad.mit.edu	37	chr16	10971201	10971201	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacacaatgcgttgcctggCtccacgccctgctgggtcct	5	10	10	16	2	0	0	0	0	0	0	2	0	2	0	4	2	4	3	4	2	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:10971201C>T	uc002dai.3	+	1	147	c.14C>T	c.(13-15)GCT>GTT	p.A5V	CIITA_uc002daj.3_Missense_Mutation_p.A5V|CIITA_uc002dak.3_Missense_Mutation_p.A5V|CIITA_uc002dag.2_Missense_Mutation_p.A5V|CIITA_uc002dah.2_Missense_Mutation_p.A5V|CIITA_uc010bup.1_Missense_Mutation_p.A5V	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	5					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CGTTGCCTGGCTCCACGCCCT	0.602			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								6	13					0	0	0	0	T	10971201	T	T	10971201	3	4	166	1	0	0	0	0	1	0	0	0	3443	797	28	4	16	4	CIITA	16	10971201	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1047785	10971201	79383552	843	31171											
LITAF	9516	broad.mit.edu	37	chr16	11647435	11647435	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccaggtcagagcaccggCgttataggacagctgactca	11	6	12	12	2	2	2	2	1	0	1	2	3	2	3	2	3	3	3	2	3	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:11647435C>A	uc002daz.2	-	3	564	c.331G>T	c.(331-333)GCC>TCC	p.A111S	LITAF_uc002dba.2_Missense_Mutation_p.A111S|LITAF_uc002dbb.2_Missense_Mutation_p.A111S|LITAF_uc002dbc.2_Missense_Mutation_p.A111S|LITAF_uc002dbd.2_Missense_Mutation_p.A111S	NM_004862	NP_004853	Q99732	LITAF_HUMAN	lipopolysaccharide-induced TNF-alpha factor	111					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|lysosomal membrane	signal transducer activity|WW domain binding			liver(1)	1						AGAGCACCGGCGTTATAGGAC	0.592													13	39					9.31168e-06	1.61085e-05	1	0	A	11647435	A	A	11647435	3	1	166	1	0	0	0	0	1	0	0	0	8872	768	27	3	248	3	LITAF	16	11647435	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	676234	11647435	78707318	844	31172											
GP2	2813	broad.mit.edu	37	chr16	20327337	20327337	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcgatggccggtacttcaCtgcggacttgacttcttgag	6	12	13	10	3	2	2	1	2	1	0	3	4	2	3	1	4	2	1	1	4	1	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20327337C>A	uc002dgv.2	-	10	1534	c.1451G>T	c.(1450-1452)AGT>ATT	p.S484I	GP2_uc002dgw.2_Missense_Mutation_p.S481I|GP2_uc002dgx.2_Missense_Mutation_p.S337I|GP2_uc002dgy.2_Missense_Mutation_p.S334I	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	484	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						CGGTACTTCACTGCGGACTTG	0.483													24	85					2.79863e-10	5.44179e-10	1	0	A	20327337	A	A	20327337	3	1	166	1	0	0	0	0	1	0	0	0	6620	565	20	4	174	4	GP2	16	20327337	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8679902	20327337	70027416	845	31173											
PDILT	204474	broad.mit.edu	37	chr16	20370759	20370759	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cagcgggctcttccagcttgGatacgtacttggtcatgttc	6	13	11	11	2	2	0	1	0	1	0	4	1	3	1	1	3	4	4	1	3	2	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20370759G>C	uc002dhc.1	-	12	1860	c.1637C>G	c.(1636-1638)TCC>TGC	p.S546C		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	546					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TTCCAGCTTGGATACGTACTT	0.512													50	245					0	0	0	0	C	20370759	C	C	20370759	3	2	166	1	0	0	0	0	1	0	0	0	11728	1174	41	2	121	2	PDILT	16	20370759	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	43422	20370759	69983994	846	31174											
ACSM5	54988	broad.mit.edu	37	chr16	20442556	20442556	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taccagattgtggatgatgaGggcaacgtcctgcctcctgg	8	10	13	10	1	0	3	0	2	0	1	2	4	2	4	4	3	3	1	4	3	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20442556G>A	uc002dhe.2	+	10	1368	c.1221G>A	c.(1219-1221)GAG>GAA	p.E407E		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	407					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TGGATGATGAGGGCAACGTCC	0.557													37	129					0	0	0	0	A	20442556	A	A	20442556	2	1	166	1	0	0	0	0	0	0	0	1	187	991	35	4		4	ACSM5	16	20442556	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	71797	20442556	69912197	847	31175											
DNAH3	55567	broad.mit.edu	37	chr16	20948070	20948070	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacatggctggcactttaccCacaagcatgctgttaaagac	12	9	8	12	0	0	1	0	0	0	1	0	1	0	1	1	2	3	5	1	2	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20948070C>T	uc010vbe.1	-	60	11760	c.11760G>A	c.(11758-11760)GTG>GTA	p.V3920V	DNAH3_uc010vbd.1_Silent_p.V1355V	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3920					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCACTTTACCCACAAGCATGC	0.572													7	17					0	0	0	0	T	20948070	T	T	20948070	2	4	166	1	0	0	0	0	0	0	0	1	4625	581	21	4		4	DNAH3	16	20948070	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	505514	20948070	69406683	848	31176											
VWA3A	146177	broad.mit.edu	37	chr16	22126703	22126703	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctgggtaaagacgctgcAgcctgatggaggcagcaacc	10	6	14	11	1	1	2	0	1	1	1	1	3	1	3	2	3	4	6	2	3	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:22126703A>G	uc010vbq.1	+	9	821	c.725A>G	c.(724-726)CAG>CGG	p.Q242R	VWA3A_uc010bxc.2_Missense_Mutation_p.Q229R	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	242						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		AAGACGCTGCAGCCTGATGGA	0.453													3	17					0	0	0	0	G	22126703	G	G	22126703	3	3	166	1	0	0	0	0	1	0	0	0	17308	188	7	5	759	5	VWA3A	16	22126703	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1178633	22126703	68228050	849	31177											
CHP2	63928	broad.mit.edu	37	chr16	23768878	23768878	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaagatggacgttgagcaaAaaatgagcatccggatcctg	15	7	12	7	2	0	4	0	2	0	2	2	6	2	6	2	2	2	3	2	2	4	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:23768878A>G	uc002dmb.1	+	7	988	c.565A>G	c.(565-567)AAA>GAA	p.K189E		NM_022097	NP_071380	O43745	CHP2_HUMAN	hepatocellular carcinoma antigen gene 520	189							calcium ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(48;0.0144)		CGTTGAGCAAAAAATGAGCAT	0.527													57	177					0	0	0	0	G	23768878	G	G	23768878	3	3	166	1	0	0	0	0	1	0	0	0	3382	15	1	5	591	5	CHP2	16	23768878	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1642175	23768878	66585875	850	31178											
APOB48R	55911	broad.mit.edu	37	chr16	28508798	28508798	+	Frame_Shift_Del	DEL	G	-	-																															gggcaagaatttggtctggaGggctcagcagaggaagaggt																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:28508798delG	uc002dqb.1	+	3	2419	c.2409delG	c.(2407-2409)GAGfs	p.E803fs	uc010vct.1_Intron|APOB48R_uc010byg.1_Frame_Shift_Del_p.E341fs	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	803	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						TTGGTCTGGAGGGCTCAGCAG	0.587													---	---	---								-	28508798	-	-	28508798	7	5	166	1	0	1	0	1	0	0	0	0	786	991	35	0	2419	0	APOB48R	16	28508798	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	4739920	28508798	61845955	851	31179											
SPN	6693	broad.mit.edu	37	chr16	29675891	29675891	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgctgtggcgccggcggcAgaagcggcggactggggccc	4	4	19	14	5	0	1	0	0	0	1	0	2	0	2	3	7	2	2	3	7	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:29675891A>C	uc002dtm.2	+	2	978	c.842A>C	c.(841-843)CAG>CCG	p.Q281P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Missense_Mutation_p.Q281P|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	281	Cytoplasmic (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						CGCCGGCGGCAGAAGCGGCGG	0.697													8	20					0	0	0	0	C	29675891	C	C	29675891	3	2	166	1	0	0	0	0	1	0	0	0	15139	188	7	5	844	5	SPN	16	29675891	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1167093	29675891	60678862	852	31180											
TBX6	6911	broad.mit.edu	37	chr16	30100304	30100304	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgttggtgagcttgacaCgatggaaagacacaggctgc	10	9	14	8	1	0	3	0	2	0	1	0	5	0	4	0	3	3	4	0	3	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:30100304C>T	uc010veh.1	-	4	641	c.581G>A	c.(580-582)CGT>CAT	p.R194H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TBX6_uc002dwk.1_Missense_Mutation_p.R194H	NM_004608	NP_004599	O95947	TBX6_HUMAN	T-box 6	194	T-box.				anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GAGCTTGACACGATGGAAAGA	0.647													44	122					0	0	0	0	T	30100304	T	T	30100304	3	4	166	1	0	0	0	0	1	0	0	0	15728	536	19	1	753	1	TBX6	16	30100304	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	424413	30100304	60254449	853	31181											
ZNF629	23361	broad.mit.edu	37	chr16	30794552	30794552	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcctcgcgcaggtgagtcCgctggtgcttgatgagggtg	4	10	18	9	3	0	3	0	3	0	0	3	3	2	3	2	4	1	3	2	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:30794552C>A	uc002dzs.1	-	3	1305	c.1097G>T	c.(1096-1098)CGG>CTG	p.R366L		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	366	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			CAGGTGAGTCCGCTGGTGCTT	0.662													19	25					2.5808e-16	5.72213e-16	1	0	A	30794552	A	A	30794552	3	1	166	1	0	0	0	0	1	0	0	0	18120	652	23	3	1516	3	ZNF629	16	30794552	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	694248	30794552	59560201	854	31182											
CYLD	1540	broad.mit.edu	37	chr16	50811792	50811792	+	Frame_Shift_Del	DEL	G	-	-																															aattattttataccttaaatGggtcttctgttgactcacaa																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:50811792delG	uc002egp.1	+	8	1493	c.1078delG	c.(1078-1080)GGGfs	p.G360fs	CYLD_uc002egn.1_Frame_Shift_Del_p.G357fs|CYLD_uc002ego.2_Frame_Shift_Del_p.G357fs|CYLD_uc010cbs.1_Frame_Shift_Del_p.G357fs|CYLD_uc002egq.1_Frame_Shift_Del_p.G357fs|CYLD_uc002egr.1_Frame_Shift_Del_p.G357fs|CYLD_uc002egs.1_Frame_Shift_Del_p.G357fs	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	360	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TACCTTAAATGGGTCTTCTGT	0.299			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				---	---	---								-	50811792	-	-	50811792	7	5	166	1	0	1	0	1	0	0	0	0	4160	1348	47	0	1100	0	CYLD	16	50811792	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	20017240	50811792	39542961	855	31183											
SALL1	6299	broad.mit.edu	37	chr16	51175026	51175026	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgaggacgatgatgagacCgctgggttgctgacatggga	9	8	18	6	2	0	4	0	4	0	1	0	8	0	6	1	4	1	3	1	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:51175026C>G	uc010vgs.1	-	2	1138	c.1107G>C	c.(1105-1107)GCG>GCC	p.A369A	SALL1_uc010vgr.1_Silent_p.A272A|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	369					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ATGATGAGACCGCTGGGTTGC	0.512													14	37					0	0	0	0	G	51175026	G	G	51175026	2	3	166	1	0	0	0	0	0	0	0	1	13875	639	23	3		3	SALL1	16	51175026	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	363234	51175026	39179727	856	31184											
IRX6	79190	broad.mit.edu	37	chr16	55360356	55360356	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccgctctctgctgcgcacccTacgatagtcgactgctgggc	5	9	11	16	4	1	0	0	0	1	0	3	2	1	0	2	1	4	4	2	1	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:55360356T>A	uc002ehy.2	+	2	687	c.154T>A	c.(154-156)TAC>AAC	p.Y52N	IRX6_uc002ehx.2_Missense_Mutation_p.Y52N|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	52						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						CTGCGCACCCTACGATAGTCG	0.652													15	15					0	0	0	0	A	55360356	A	A	55360356	3	1	166	1	0	0	0	0	1	0	0	0	7887	1522	53	5	160	5	IRX6	16	55360356	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	4185330	55360356	34994397	857	31185											
CDH11	1009	broad.mit.edu	37	chr16	65016141	65016141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attgctgataaacttcgggtCgatgtgcacgttggctgcct	7	13	12	9	3	0	1	0	1	0	0	2	2	0	1	1	2	4	4	1	2	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:65016141C>T	uc002eoi.2	-	8	1497	c.1063G>A	c.(1063-1065)GAC>AAC	p.D355N	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Missense_Mutation_p.D355N|CDH11_uc010vin.1_Missense_Mutation_p.D229N|CDH11_uc002eok.1_RNA	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	355	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AACTTCGGGTCGATGTGCACG	0.468			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			19	22					0	0	0	0	T	65016141	T	T	65016141	3	4	166	1	0	0	0	0	1	0	0	0	3112	884	31	1	1351	1	CDH11	16	65016141	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	9655785	65016141	25338612	858	31186											
TMED6	146456	broad.mit.edu	37	chr16	69377541	69377541	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgcaccttttgtgtgccGtcctatgagagagacaattt	8	15	9	9	1	1	2	0	1	1	2	2	4	2	2	3	0	2	1	3	0	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:69377541G>A	uc002exc.1	-	4	525	c.492C>T	c.(490-492)GAC>GAT	p.D164D		NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain	164	Lumenal (Potential).				transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1						TTTGTGTGCCGTCCTATGAGA	0.428													30	29					0	0	0	0	A	69377541	A	A	69377541	2	1	166	1	0	0	0	0	0	0	0	1	16074	1136	40	1		1	TMED6	16	69377541	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4361400	69377541	20977212	859	31187											
PLCG2	5336	broad.mit.edu	37	chr16	81979842	81979842	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tagagctggcttccctcctgGttttctgtgagatgcggcca	5	13	12	11	1	1	2	0	1	1	2	3	3	3	2	3	3	2	3	3	3	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:81979842G>C	uc002fgt.2	+	31	3696	c.3544G>C	c.(3544-3546)GTT>CTT	p.V1182L		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	1182					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TTCCCTCCTGGTTTTCTGTGA	0.527													24	44					0	0	0	0	C	81979842	C	C	81979842	3	2	166	1	0	0	0	0	1	0	0	0	12091	1261	44	4	3662	4	PLCG2	16	81979842	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	12602301	81979842	8374911	860	31188											
MYO1C	4641	broad.mit.edu	37	chr17	1386207	1386207	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgcacggcacctccgcgcTcgggggctgggcaggtctct	3	6	15	17	5	1	0	0	0	1	0	4	0	2	0	3	5	0	5	3	5	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:1386207T>G	uc002fsp.2	-	4	714	c.494A>C	c.(493-495)GAG>GCG	p.E165A	MYO1C_uc002fsn.2_Missense_Mutation_p.E146A|MYO1C_uc002fso.2_Missense_Mutation_p.E130A|MYO1C_uc010vqj.1_Missense_Mutation_p.E130A|MYO1C_uc010vqk.1_Missense_Mutation_p.E141A	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	165	Myosin head-like.			E -> Q (in Ref. 1; CAA67131).	mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		ACCTCCGCGCTCGGGGGCTGG	0.632													13	30					0	0	0	0	G	1386207	G	G	1386207	3	3	166	1	0	0	0	0	1	0	0	0	10123	1551	54	5	2813	5	MYO1C	17	1386207	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08		1386207	79809003	861	31189											
RTN4RL1	146760	broad.mit.edu	37	chr17	1841024	1841025	+	Frame_Shift_Del	DEL	CA	-	-																															ccgtcatgggcgccgggtagCacacacagtcccgtgggcag																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:1841024_1841025delCA	uc002ftp.2	-	2	110_111	c.91_92delTG	c.(91-93)TGCfs	p.C31fs		NM_178568	NP_848663	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1 precursor	31	LRRNT.				axon regeneration	anchored to plasma membrane	receptor activity				0						CGCCGGGTAGCACACACAGTCC	0.658													---	---	---								-	1841025	-	-	1841024	7	5	166	1	0	1	0	1	0	0	0	0	13796	710	25	0	1237	0	RTN4RL1	17	1841024	Frame_Shift_Del	DEL	CA	TCGA-CR-7402-01A-11D-2012-08	454817	1841024	79354186	862	31190											
SPNS3	201305	broad.mit.edu	37	chr17	4350211	4350211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggtctgggctacgtgctggGgtcggctgtgacgatgctga	4	11	18	8	3	1	2	0	2	1	0	2	3	1	2	0	5	3	4	0	5	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:4350211G>A	uc002fxt.2	+	5	619	c.575G>A	c.(574-576)GGG>GAG	p.G192E	SPNS3_uc002fxu.2_Missense_Mutation_p.G65E	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	192	Helical; (Potential).				lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						TACGTGCTGGGGTCGGCTGTG	0.652													21	37					0	0	0	0	A	4350211	A	A	4350211	3	1	166	1	0	0	0	0	1	0	0	0	15142	1232	43	4	593	4	SPNS3	17	4350211	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2509187	4350211	76844999	863	31191											
TP53	7157	broad.mit.edu	37	chr17	7577138	7577138	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgcacctcaaagctgttcCgtcccagtagattaccacta	11	9	6	15	2	1	1	1	0	0	1	3	1	3	1	4	0	2	4	4	0	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:7577138C>G	uc002gim.2	-	8	994	c.800G>C	c.(799-801)CGG>CCG	p.R267P	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R267P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R135P|TP53_uc010cng.1_Missense_Mutation_p.R135P|TP53_uc002gii.1_Missense_Mutation_p.R135P|TP53_uc010cnh.1_Missense_Mutation_p.R267P|TP53_uc010cni.1_Missense_Mutation_p.R267P|TP53_uc002gij.2_Missense_Mutation_p.R267P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	267	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> H (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R267W(20)|p.R267P(13)|p.0?(7)|p.R267Q(7)|p.R267R(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.R267fs*78(1)|p.N268fs*77(1)|p.L265_K305del41(1)|p.R267G(1)|p.E258fs*71(1)|p.L265_R267delLGR(1)|p.R267L(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAAGCTGTTCCGTCCCAGTAG	0.527		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	17					0	0	0	0	G	7577138	G	G	7577138	3	3	166	1	0	0	0	0	1	0	0	0	16448	652	23	3	486	3	TP53	17	7577138	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3226927	7577138	73618072	864	31192											
DNAH2	146754	broad.mit.edu	37	chr17	7689567	7689567	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccaccatgatcgtgggctgCacgggcagcggcaagactgc	8	6	14	13	3	0	2	0	1	0	1	2	2	1	2	2	3	3	4	2	3	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:7689567C>T	uc002giu.1	+	39	6269	c.6255C>T	c.(6253-6255)TGC>TGT	p.C2085C		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2085	AAA 2 (By similarity).|ATP (Potential).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCGTGGGCTGCACGGGCAGCG	0.577													19	54					0	0	0	0	T	7689567	T	T	7689567	2	4	166	1	0	0	0	0	0	0	0	1	4624	718	25	4		4	DNAH2	17	7689567	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	112429	7689567	73505643	865	31193											
ALOX12B	242	broad.mit.edu	37	chr17	7977057	7977057	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggatcagctcaggcacggttCgcaagcacctagggaagcct	10	6	13	12	2	2	0	2	0	0	0	3	2	2	2	2	4	3	5	2	4	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:7977057C>G	uc002gjy.1	-	13	1934	c.1673G>C	c.(1672-1674)CGA>CCA	p.R558P		NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	558	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						AGGCACGGTTCGCAAGCACCT	0.627										Multiple Myeloma(8;0.094)	OREG0024152	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	29					0	0	0	0	G	7977057	G	G	7977057	3	3	166	1	0	0	0	0	1	0	0	0	537	884	31	3	444	3	ALOX12B	17	7977057	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	287490	7977057	73218153	866	31194											
SPDYE4	388333	broad.mit.edu	37	chr17	8656718	8656718	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atcgaagcttatggaacaagGgtcgctgggagtagttcttc	10	11	13	7	2	1	0	0	0	1	0	4	3	1	2	0	3	2	4	0	3	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:8656718G>A	uc010cnz.1	-	5	752	c.575C>T	c.(574-576)CCC>CTC	p.P192L		NM_001128076	NP_001121548	A6NLX3	SPDE4_HUMAN	speedy homolog E4	192											0						ATGGAACAAGGGTCGCTGGGA	0.567													5	14					0	0	0	0	A	8656718	A	A	8656718	3	1	166	1	0	0	0	0	1	0	0	0	15097	1232	43	4	146	4	SPDYE4	17	8656718	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	679661	8656718	72538492	867	31195											
MYH8	4626	broad.mit.edu	37	chr17	10304018	10304018	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcctccagttcccgggagaGgtcagagcgctgcttctccg	5	9	12	15	3	2	2	1	0	1	2	6	3	5	2	4	2	2	3	4	2	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10304018G>A	uc002gmm.2	-	27	3519	c.3424C>T	c.(3424-3426)CTC>TTC	p.L1142F	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1142	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TCCCGGGAGAGGTCAGAGCGC	0.582									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				48	119					0	0	0	0	A	10304018	A	A	10304018	3	1	166	1	0	0	0	0	1	0	0	0	10094	1000	35	4	2445	4	MYH8	17	10304018	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1647300	10304018	70891192	868	31196											
MYH4	4622	broad.mit.edu	37	chr17	10348361	10348361	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgctcagcctcatccagacGgagctgcagatccttcacgg	8	8	10	15	2	3	2	3	0	0	2	5	3	5	3	3	2	4	3	3	2	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10348361G>A	uc002gmn.2	-	37	5509	c.5398C>T	c.(5398-5400)CGT>TGT	p.R1800C	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1800	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TCATCCAGACGGAGCTGCAGA	0.562													60	111					0	0	0	0	A	10348361	A	A	10348361	3	1	166	1	0	0	0	0	1	0	0	0	10090	1116	39	1	437	1	MYH4	17	10348361	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	44343	10348361	70846849	869	31197											
MYH4	4622	broad.mit.edu	37	chr17	10354160	10354160	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtaaatgcttgtttgcctcgGgatagctgagaaaccatagc	11	11	11	8	1	0	1	0	1	0	1	1	3	0	2	2	1	5	4	2	1	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10354160G>T	uc002gmn.2	-	29	4029	c.3918C>A	c.(3916-3918)TCC>TCA	p.S1306S	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1306	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GTTTGCCTCGGGATAGCTGAG	0.393													31	57					1.55811e-20	3.66614e-20	1	0	T	10354160	T	T	10354160	2	4	166	1	0	0	0	0	0	0	0	1	10090	1219	43	4		4	MYH4	17	10354160	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5799	10354160	70841050	870	31198											
MYH2	4620	broad.mit.edu	37	chr17	10424725	10424725	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggagcttgcggaatttagCtagattggtgttggattgtt	7	16	14	4	1	0	1	0	0	0	1	0	4	0	4	0	4	3	4	0	4	3	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10424725C>T	uc010coi.2	-	40	5826	c.5698G>A	c.(5698-5700)GCT>ACT	p.A1900T	uc002gml.1_Intron|MYH1_uc002gmo.2_5'Flank|MYH2_uc002gmp.3_Missense_Mutation_p.A1900T|MYH2_uc010coj.2_Missense_Mutation_p.A667T	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1900	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CGGAATTTAGCTAGATTGGTG	0.473													44	118					0	0	0	0	T	10424725	T	T	10424725	3	4	166	1	0	0	0	0	1	0	0	0	10088	797	28	4	131	4	MYH2	17	10424725	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	70565	10424725	70770485	871	31199											
MYH2	4620	broad.mit.edu	37	chr17	10428788	10428788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgtaagtttttgttctctCgcttcagggtttctagctga	5	18	10	8	1	3	1	1	1	2	0	5	1	3	1	0	1	1	7	0	1	2	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10428788C>T	uc010coi.2	-	32	4645	c.4517G>A	c.(4516-4518)CGA>CAA	p.R1506Q	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1506Q|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1506	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.R1506*(1)		ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TTTGTTCTCTCGCTTCAGGGT	0.428													27	74					0	0	0	0	T	10428788	T	T	10428788	3	4	166	1	0	0	0	0	1	0	0	0	10088	884	31	1	1344	1	MYH2	17	10428788	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4063	10428788	70766422	872	31200											
MYH2	4620	broad.mit.edu	37	chr17	10433044	10433044	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagacctgccatctcttctGtgaggtttttcacctacaaa	9	13	6	13	0	3	2	1	1	2	1	4	2	3	2	4	1	2	1	4	1	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10433044G>T	uc010coi.2	-	24	3082	c.2954C>A	c.(2953-2955)ACA>AAA	p.T985K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.T985K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	985	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CATCTCTTCTGTGAGGTTTTT	0.478													73	152					4.81439e-37	1.21132e-36	1	0	T	10433044	T	T	10433044	3	4	166	1	0	0	0	0	1	0	0	0	10088	1377	48	4	2939	4	MYH2	17	10433044	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	4256	10433044	70762166	873	31201											
DNAH9	1770	broad.mit.edu	37	chr17	11522951	11522951	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caagtggtctcagacactttGagcttcttcaagcaagagtt	11	12	9	9	0	3	3	2	1	2	2	4	3	3	3	0	1	2	3	0	1	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:11522951G>C	uc002gne.2	+	6	1271	c.1203G>C	c.(1201-1203)TTG>TTC	p.L401F		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	401	Potential.|Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAGACACTTTGAGCTTCTTCA	0.443													45	103					0	0	0	0	C	11522951	C	C	11522951	3	2	166	1	0	0	0	0	1	0	0	0	4630	1281	45	2	1225	2	DNAH9	17	11522951	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1089907	11522951	69672259	874	31202											
DNAH9	1770	broad.mit.edu	37	chr17	11648295	11648295	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggcctgatcggggacctctTtcccgccctggatgtccccc	3	9	12	17	2	1	1	0	1	1	0	4	3	3	3	6	4	0	0	6	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:11648295T>A	uc002gne.2	+	31	6361	c.6293T>A	c.(6292-6294)TTT>TAT	p.F2098Y	DNAH9_uc010coo.2_Missense_Mutation_p.F1392Y	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2098					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGGGACCTCTTTCCCGCCCTG	0.562													18	49					0	0	0	0	A	11648295	A	A	11648295	3	1	166	1	0	0	0	0	1	0	0	0	4630	1841	64	5	6415	5	DNAH9	17	11648295	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	125344	11648295	69546915	875	31203											
MYOCD	93649	broad.mit.edu	37	chr17	12620739	12620739	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	taatatgcacatactccaagGtaaggctgcaagaaatcaga	17	8	8	8	0	1	2	1	0	0	2	2	2	2	2	1	2	3	4	1	2	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:12620739G>T	uc002gnn.2	+	4	552	c.253_splice	c.e4+1	p.A85_splice	MYOCD_uc002gno.2_Splice_Site_p.A85_splice|MYOCD_uc002gnp.1_5'Flank	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2						cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ATACTCCAAGGTAAGGCTGCA	0.443													7	23					0.00198382	0.00322679	1	0	T	12620739	T	T	12620739	5	4	166	1	0	0	0	0	0	0	1	0	10140	1275	44	4	268	4	MYOCD	17	12620739	Splice_Site	SNP	G	TCGA-CR-7402-01A-11D-2012-08	972444	12620739	68574471	876	31204											
KCNJ12	3768	broad.mit.edu	37	chr17	21318738	21318738	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtcaccatgtcgggcgcCaacggcttcggcaacggcaa	8	6	13	14	5	1	0	1	0	0	0	3	0	1	0	2	5	2	3	2	5	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:21318738C>T	uc002gyv.1	+	3	789	c.84C>T	c.(82-84)GCC>GCT	p.A28A		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	28	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TGTCGGGCGCCAACGGCTTCG	0.657										Prostate(3;0.18)			5	43					0	0	0	0	T	21318738	T	T	21318738	2	4	166	1	0	0	0	0	0	0	0	1	8085	581	21	4		4	KCNJ12	17	21318738	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8697999	21318738	59876472	877	31205											
CCL7	6354	broad.mit.edu	37	chr17	32597383	32597383	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccaggggcttgctcagcCaggtaaggtccctctctcct	5	9	10	17	0	2	0	1	0	1	0	5	0	4	0	5	4	2	3	5	4	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:32597383C>A	uc002hhz.2	+	1	144	c.74C>A	c.(73-75)CCA>CAA	p.P25Q	CCL7_uc010ctf.2_RNA	NM_006273	NP_006264	P80098	CCL7_HUMAN	chemokine (C-C motif) ligand 7 precursor	25					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			ovary(1)	1	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)		CTTGCTCAGCCAGGTAAGGTC	0.552													24	44					9.95505e-16	2.17282e-15	1	0	A	32597383	A	A	32597383	3	1	166	1	0	0	0	0	1	0	0	0	2921	594	21	4	76	4	CCL7	17	32597383	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	11278645	32597383	48597827	878	31206											
CCL8	6355	broad.mit.edu	37	chr17	32646545	32646545	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtttctgcagcgcttctgTgcctgctgctcatggcagcc	4	12	12	13	1	3	0	1	0	2	0	3	0	3	0	2	2	6	6	2	2	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:32646545T>C	uc002hib.2	+	1	480	c.25T>C	c.(25-27)TGC>CGC	p.C9R		NM_005623	NP_005614	P80075	CCL8_HUMAN	small inducible cytokine A8 precursor	9					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity				0		Ovarian(249;0.0443)|Breast(31;0.151)				AGCGCTTCTGTGCCTGCTGCT	0.527													35	49					0	0	0	0	C	32646545	C	C	32646545	3	2	166	1	0	0	0	0	1	0	0	0	2922	1696	59	5	27	5	CCL8	17	32646545	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	49162	32646545	48548665	879	31207											
ACACA	31	broad.mit.edu	37	chr17	35468548	35468548	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttctgcggaatttgatttcTactgtcccttctggctccag	5	17	8	11	1	3	1	0	1	3	0	5	2	5	2	2	2	2	1	2	2	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:35468548T>G	uc002hnm.2	-	52	6563	c.6372A>C	c.(6370-6372)GTA>GTC	p.V2124V	ACACA_uc002hnk.2_Silent_p.V2046V|ACACA_uc002hnl.2_Silent_p.V2066V|ACACA_uc002hnn.2_Silent_p.V2124V|ACACA_uc002hno.2_Silent_p.V2161V|ACACA_uc010cuy.2_Silent_p.V769V|ACACA_uc010wdb.1_Silent_p.V162V|ACACA_uc010wdc.1_Silent_p.V250V	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	2124	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ATTTGATTTCTACTGTCCCTT	0.458													27	71					0	0	0	0	G	35468548	G	G	35468548	2	3	166	1	0	0	0	0	0	0	0	1	106	1509	53	5		5	ACACA	17	35468548	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2822003	35468548	45726662	880	31208											
RPL23	9349	broad.mit.edu	37	chr17	37009953	37009953	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccagaaacaaaacctcacctCgcttcgacatcttgaacgcc	13	7	5	16	3	2	2	1	1	1	1	4	3	2	2	4	0	3	1	4	0	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:37009953C>G	uc002hqx.1	-	1	101	c.11G>C	c.(10-12)CGA>CCA	p.R4P	RPL23_uc002hqw.1_5'Flank|RPL23_uc002hqy.1_Missense_Mutation_p.R4P|SNORA21_uc002hqz.1_5'Flank	NM_000978	NP_000969	P62829	RL23_HUMAN	ribosomal protein L23	4					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome				0						AACCTCACCTCGCTTCGACAT	0.562													5	26					0	0	0	0	G	37009953	G	G	37009953	3	3	166	1	0	0	0	0	1	0	0	0	13635	884	31	3	431	3	RPL23	17	37009953	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1541405	37009953	44185257	881	31209											
KRT25	147183	broad.mit.edu	37	chr17	38910665	38910665	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaatcatcagctgtaagcCtggcattatcgatctgcaga	12	11	9	9	1	3	2	2	1	1	1	4	3	3	2	1	1	3	4	1	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:38910665C>T	uc002hve.2	-	2	546	c.485G>A	c.(484-486)AGG>AAG	p.R162K		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	162	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				AGCTGTAAGCCTGGCATTATC	0.393													27	73					0	0	0	0	T	38910665	T	T	38910665	3	4	166	1	0	0	0	0	1	0	0	0	8501	681	24	4	895	4	KRT25	17	38910665	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1900712	38910665	42284545	882	31210											
KRT12	3859	broad.mit.edu	37	chr17	39019473	39019473	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtggtccacgttctggcgCtctgcgtccgcgcgcacctg	2	10	14	15	6	2	0	0	0	2	0	4	0	4	0	3	3	1	3	3	3	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39019473C>A	uc002hvk.2	-	6	1242	c.1218G>T	c.(1216-1218)GAG>GAT	p.E406D		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	406	Rod.|Coil 2.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CGTTCTGGCGCTCTGCGTCCG	0.672													18	26					3.32936e-07	5.99774e-07	1	0	A	39019473	A	A	39019473	3	1	166	1	0	0	0	0	1	0	0	0	8488	796	28	4	278	4	KRT12	17	39019473	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	108808	39019473	42175737	883	31211											
KRTAP1-3	81850	broad.mit.edu	37	chr17	39190992	39190992	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcagctggtctcacagcagcTtggctggcagcagctggagc	7	7	15	12	0	1	0	1	0	1	0	2	1	1	1	0	4	6	8	0	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39190992T>C	uc002hvv.2	-	1	116	c.82A>G	c.(82-84)AGC>GGC	p.S28G		NM_030966	NP_112228	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	28						extracellular region|keratin filament	structural constituent of epidermis				0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TCACAGCAGCTTGGCTGGCAG	0.597													34	57					0	0	0	0	C	39190992	C	C	39190992	3	2	166	1	0	0	0	0	1	0	0	0	8542	1609	56	5	425	5	KRTAP1-3	17	39190992	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	171519	39190992	42004218	884	31212											
KRT33B	3884	broad.mit.edu	37	chr17	39521745	39521745	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctggttcaggtccacagcggGagcagcgtccacctccacgt	7	7	12	15	3	1	0	1	0	0	0	4	1	4	1	4	3	3	2	4	3	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39521745G>T	uc002hwl.2	-	4	694	c.649C>A	c.(649-651)CCC>ACC	p.P217T		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	217	Linker 12.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				TCCACAGCGGGAGCAGCGTCC	0.557													17	49					4.14922e-12	8.30691e-12	1	0	T	39521745	T	T	39521745	3	4	166	1	0	0	0	0	1	0	0	0	8509	1174	41	2	581	2	KRT33B	17	39521745	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	330753	39521745	41673465	885	31213											
KRT34	3885	broad.mit.edu	37	chr17	39535393	39535393	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgggagctgtagtgggcCtcgctctccgtcagcgtgtt	4	11	15	11	3	2	0	1	0	1	0	4	1	2	1	2	2	3	5	2	2	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39535393C>A	uc002hwm.2	-	6	1050	c.1038G>T	c.(1036-1038)GAG>GAT	p.E346D		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	346	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TGTAGTGGGCCTCGCTCTCCG	0.577													39	65					3.66082e-28	8.99148e-28	1	0	A	39535393	A	A	39535393	3	1	166	1	0	0	0	0	1	0	0	0	8510	680	24	4	280	4	KRT34	17	39535393	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	13648	39535393	41659817	886	31214											
FAM134C	162427	broad.mit.edu	37	chr17	40734205	40734205	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgtcgtcctcatcatccaGgccagcaggatccatattaa	11	10	8	12	1	2	0	2	0	0	0	6	1	5	1	4	2	1	1	4	2	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:40734205G>C	uc002ial.2	-	9	1130	c.1027C>G	c.(1027-1029)CTG>GTG	p.L343V	FAM134C_uc010wgq.1_Missense_Mutation_p.L143V|FAM134C_uc002iam.1_Missense_Mutation_p.L143V|FAM134C_uc010cyk.1_Missense_Mutation_p.L246V	NM_178126	NP_835227	Q86VR2	F134C_HUMAN	hypothetical protein LOC162427	343						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		TCATCATCCAGGCCAGCAGGA	0.567													39	90					0	0	0	0	C	40734205	C	C	40734205	3	2	166	1	0	0	0	0	1	0	0	0	5475	991	35	4	377	4	FAM134C	17	40734205	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1198812	40734205	40461005	887	31215											
RUNDC1	146923	broad.mit.edu	37	chr17	41133041	41133041	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccggcgaccccgccagcgatGagggcgatgggctgccaggg	6	3	18	14	5	0	1	0	1	0	0	0	4	0	1	5	4	2	1	5	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:41133041G>C	uc002ici.1	+	1	460	c.448G>C	c.(448-450)GAG>CAG	p.E150Q	AARSD1_uc002icd.2_5'Flank|AARSD1_uc002ice.2_5'Flank|AARSD1_uc002icf.2_5'Flank|AARSD1_uc010whg.1_5'Flank|AARSD1_uc002icg.2_5'Flank|AARSD1_uc002ich.2_5'Flank|AARSD1_uc010whh.1_5'Flank|RUNDC1_uc010whi.1_5'UTR	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	150											0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CGCCAGCGATGAGGGCGATGG	0.697													4	6					0	0	0	0	C	41133041	C	C	41133041	3	2	166	1	0	0	0	0	1	0	0	0	13807	1291	45	2	450	2	RUNDC1	17	41133041	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	398836	41133041	40062169	888	31216											
ADAM11	4185	broad.mit.edu	37	chr17	42854579	42854579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagctgaatgtggaggggaCggagcgtgggagctgtgggc	8	6	22	5	2	0	1	0	1	0	0	0	6	0	5	0	6	3	2	0	6	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:42854579C>T	uc002ihh.2	+	21	1727	c.1727C>T	c.(1726-1728)ACG>ATG	p.T576M	ADAM11_uc010wjd.1_Missense_Mutation_p.T376M|ADAM11_uc002ihi.2_5'Flank	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	576	Cys-rich.|Extracellular (Potential).				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GTGGAGGGGACGGAGCGTGGG	0.647													9	35					0	0	0	0	T	42854579	T	T	42854579	3	4	166	1	0	0	0	0	1	0	0	0	235	536	19	1	1809	1	ADAM11	17	42854579	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1721538	42854579	38340631	889	31217											
EFTUD2	9343	broad.mit.edu	37	chr17	42931930	42931931	+	Missense_Mutation	DNP	GG	AA	AA																															cagttctgctgtacctcagaGggcagagtatcatccaccag																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:42931930_42931931GG>AA	uc002ihn.2	-	22	2513_2514	c.2252_2253CC>TT	c.(2251-2253)CCC>CTT	p.P751L	EFTUD2_uc010wje.1_Missense_Mutation_p.P716L|EFTUD2_uc010wjf.1_Missense_Mutation_p.P741L	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	751						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				GTACCTCAGAGGGCAGAGTATC	0.52													26	101					0	0	0	0	AA	42931931	AA	AA	42931930	3	1	166	1	0	0	0	0	1	0	0	0	4983	987	35	4	693	4	EFTUD2	17	42931930	Missense_Mutation	DNP	GG	TCGA-CR-7402-01A-11D-2012-08	77351	42931930	38263280	890	31218											
UTP18	51096	broad.mit.edu	37	chr17	49353297	49353297	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcatctgtgcagttccatcCcggtgcacagattgtgatgg	7	12	11	11	1	2	2	1	1	1	1	4	2	4	2	2	2	2	3	2	2	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:49353297C>A	uc002its.2	+	6	831	c.782C>A	c.(781-783)CCC>CAC	p.P261H		NM_016001	NP_057085	Q9Y5J1	UTP18_HUMAN	UTP18, small subunit processome component	261	WD 1.				rRNA processing	nucleolus					0			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			CAGTTCCATCCCGGTGCACAG	0.383													14	21					2.32078e-09	4.43347e-09	1	0	A	49353297	A	A	49353297	3	1	166	1	0	0	0	0	1	0	0	0	17166	623	22	4	804	4	UTP18	17	49353297	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	6421367	49353297	31841913	891	31219											
MSI2	124540	broad.mit.edu	37	chr17	55607074	55607074	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatgtttgataaaactaccaAcaggcacagaggtaagatta	17	9	9	6	0	0	3	0	1	0	2	0	4	0	3	1	2	3	3	1	2	6	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:55607074A>G	uc002iuz.1	+	7	616	c.443A>G	c.(442-444)AAC>AGC	p.N148S	MSI2_uc010wnm.1_Missense_Mutation_p.N126S|MSI2_uc002iva.2_Missense_Mutation_p.N144S	NM_138962	NP_620412	Q96DH6	MSI2H_HUMAN	musashi 2 isoform a	148	RRM 2.					cytoplasm	nucleotide binding|RNA binding	p.N144S(1)		central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		AAAACTACCAACAGGCACAGA	0.308			T	HOXA9	CML								13	30					0	0	0	0	G	55607074	G	G	55607074	3	3	166	1	0	0	0	0	1	0	0	0	9929	43	2	5	519	5	MSI2	17	55607074	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	6253777	55607074	25588136	892	31220											
C17orf47	284083	broad.mit.edu	37	chr17	56619276	56619276	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggcccataggagggaaaagCacagaccttttagccaccag	13	5	12	11	0	0	1	0	0	0	1	0	3	0	3	4	3	2	1	4	3	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:56619276C>A	uc002iwq.1	-	2	1749	c.1613G>T	c.(1612-1614)TGC>TTC	p.C538F	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	538										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGGGAAAAGCACAGACCTTT	0.493													46	102					2.00842e-17	4.51434e-17	1	0	A	56619276	A	A	56619276	3	1	166	1	0	0	0	0	1	0	0	0	1865	710	25	4	103	4	C17orf47	17	56619276	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1012202	56619276	24575934	893	31221											
CCDC47	57003	broad.mit.edu	37	chr17	61833679	61833679	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccggcagtccatactttgctCcagacttaggtttatcacta	9	13	7	12	1	1	1	1	0	0	1	3	1	3	1	3	2	2	3	3	2	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:61833679C>A	uc002jbs.3	-	8	1205	c.869G>T	c.(868-870)GGA>GTA	p.G290V	CCDC47_uc010ddx.2_Missense_Mutation_p.G290V|CCDC47_uc002jbt.2_Missense_Mutation_p.G290V	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	290						integral to membrane	protein binding				0						ATACTTTGCTCCAGACTTAGG	0.408													21	49					2.37509e-13	4.88989e-13	1	0	A	61833679	A	A	61833679	3	1	166	1	0	0	0	0	1	0	0	0	2831	855	30	2	606	2	CCDC47	17	61833679	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5214403	61833679	19361531	894	31222											
CCDC47	57003	broad.mit.edu	37	chr17	61843413	61843413	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttccatgacatcctcaaaTtcagcgaagtcattatcatc	12	13	4	12	1	5	1	4	1	1	0	8	2	7	1	2	0	1	0	2	0	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:61843413T>C	uc002jbs.3	-	2	459	c.123A>G	c.(121-123)GAA>GAG	p.E41E	CCDC47_uc010ddx.2_Silent_p.E41E|CCDC47_uc002jbt.2_Silent_p.E41E	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	41						integral to membrane	protein binding				0						CATCCTCAAATTCAGCGAAGT	0.443													59	129					0	0	0	0	C	61843413	C	C	61843413	2	2	166	1	0	0	0	0	0	0	0	1	2831	1490	52	5		5	CCDC47	17	61843413	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	9734	61843413	19351797	895	31223											
RGS9	8787	broad.mit.edu	37	chr17	63206682	63206682	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagacagctggaagaggaaGccaaggcccgagaagcagcc	14	2	15	10	1	0	3	0	1	0	3	0	7	0	5	3	3	4	2	3	3	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:63206682G>T	uc002jfe.2	+	17	1476	c.1366G>T	c.(1366-1368)GCC>TCC	p.A456S	RGS9_uc010dem.2_Missense_Mutation_p.A453S|RGS9_uc002jfd.2_Missense_Mutation_p.A453S|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.A227S	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	456					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						GGAAGAGGAAGCCAAGGCCCG	0.567													28	69					1.5548e-18	3.5559e-18	1	0	T	63206682	T	T	63206682	3	4	166	1	0	0	0	0	1	0	0	0	13378	971	34	4	1432	4	RGS9	17	63206682	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1363269	63206682	17988528	896	31224											
HELZ	9931	broad.mit.edu	37	chr17	65119097	65119097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccacttacaggtaaaggcaCcgacataactacattccctc	13	9	5	14	1	0	0	0	0	0	0	3	1	2	0	3	2	3	2	3	2	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:65119097C>T	uc010wqk.1	-	26	3809	c.3622G>A	c.(3622-3624)GTG>ATG	p.V1208M	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.V1207M	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GGTAAAGGCACCGACATAACT	0.378													11	47					0	0	0	0	T	65119097	T	T	65119097	3	4	166	1	0	0	0	0	1	0	0	0	7088	507	18	4	2241	4	HELZ	17	65119097	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1912415	65119097	16076113	897	31225											
HELZ	9931	broad.mit.edu	37	chr17	65162623	65162623	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccatggtatggtgggagtCatactgatgtctggaaacaa	11	11	12	7	0	2	1	1	1	1	0	3	3	3	3	1	4	2	1	1	4	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:65162623C>T	uc010wqk.1	-	15	2053	c.1866G>A	c.(1864-1866)ATG>ATA	p.M622I	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.M622I	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TGGTGGGAGTCATACTGATGT	0.363													20	44					0	0	0	0	T	65162623	T	T	65162623	3	4	166	1	0	0	0	0	1	0	0	0	7088	826	29	2	4038	2	HELZ	17	65162623	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	43526	65162623	16032587	898	31226											
NOL11	25926	broad.mit.edu	37	chr17	65717512	65717512	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttgtcagcagaagtatatAggatactttcagtgcaaggg	13	11	12	5	0	2	1	2	0	0	1	2	2	2	2	0	2	3	4	0	2	6	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:65717512A>G	uc002jgd.1	+	4	334	c.331A>G	c.(331-333)AGG>GGG	p.R111G	NOL11_uc010wql.1_Translation_Start_Site|NOL11_uc010deu.1_Translation_Start_Site	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	111						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			AGAAGTATATAGGATACTTTC	0.358													16	61					0	0	0	0	G	65717512	G	G	65717512	3	3	166	1	0	0	0	0	1	0	0	0	10575	411	15	5	345	5	NOL11	17	65717512	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	554889	65717512	15477698	899	31227											
ABCA8	10351	broad.mit.edu	37	chr17	66871844	66871844	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttaggagggcacccctttcCgtgtttctaaaggtggcccg	6	11	13	11	2	1	0	0	0	1	0	2	1	2	1	4	4	0	3	4	4	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:66871844C>G	uc002jhp.2	-	34	4460	c.4281G>C	c.(4279-4281)ACG>ACC	p.T1427T	ABCA8_uc002jhq.2_Silent_p.T1467T|ABCA8_uc010wqq.1_Silent_p.T1462T	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1427	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CACCCCTTTCCGTGTTTCTAA	0.488													12	32					0	0	0	0	G	66871844	G	G	66871844	2	3	166	1	0	0	0	0	0	0	0	1	38	639	23	3		3	ABCA8	17	66871844	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1154332	66871844	14323366	900	31228											
DNAI2	64446	broad.mit.edu	37	chr17	72301505	72301505	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaccccttctacccgaagAacttcctgacggttggcgac	10	8	9	14	3	1	2	0	1	1	1	2	5	2	2	4	2	3	1	4	2	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:72301505A>T	uc002jkf.2	+	9	1234	c.1135A>T	c.(1135-1137)AAC>TAC	p.N379Y	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_3'UTR|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	379	WD 4.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CTACCCGAAGAACTTCCTGAC	0.577									Kartagener_syndrome				34	36					0	0	0	0	T	72301505	T	T	72301505	3	4	166	1	0	0	0	0	1	0	0	0	4632	246	9	5	1165	5	DNAI2	17	72301505	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	5429661	72301505	8893705	901	31229											
LLGL2	3993	broad.mit.edu	37	chr17	73569302	73569302	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggtgcgctacagctgcAtccgccgggaggacgtcagt	7	6	14	14	4	1	0	1	0	0	0	2	2	2	2	3	3	4	3	3	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:73569302A>G	uc002joh.2	+	20	2822	c.2668A>G	c.(2668-2670)ATC>GTC	p.I890V	LLGL2_uc002joi.2_Missense_Mutation_p.I890V|LLGL2_uc010dgg.1_Missense_Mutation_p.I890V|LLGL2_uc002joj.2_Missense_Mutation_p.I879V|LLGL2_uc010wsd.1_Missense_Mutation_p.I517V	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	890					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CTACAGCTGCATCCGCCGGGA	0.662													28	59					0	0	0	0	G	73569302	G	G	73569302	3	3	166	1	0	0	0	0	1	0	0	0	8876	217	8	5	2777	5	LLGL2	17	73569302	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1267797	73569302	7625908	902	31230											
AFMID	125061	broad.mit.edu	37	chr17	76200969	76200969	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcgtttgtccagaagcggtAtccaagcaacaagtgggtgt	10	10	13	8	2	0	1	0	0	0	1	2	1	2	1	2	2	4	3	2	2	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:76200969A>G	uc002jva.3	+	6	470	c.455A>G	c.(454-456)TAT>TGT	p.Y152C	AFMID_uc002jvb.3_Intron|AFMID_uc002juz.3_Missense_Mutation_p.Y152C	NM_001010982	NP_001010982	Q63HM1	AFMID_HUMAN	arylformamidase isoform 1	152						cytosol|nucleus	arylformamidase activity			large_intestine(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			CAGAAGCGGTATCCAAGCAAC	0.557													11	26					0	0	0	0	G	76200969	G	G	76200969	3	3	166	1	0	0	0	0	1	0	0	0	362	449	16	5	477	5	AFMID	17	76200969	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2631667	76200969	4994241	903	31231											
AZI1	22994	broad.mit.edu	37	chr17	79176070	79176070	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctccgtcacctccttcCgcctgggcaagcccgtgctg	3	9	9	20	3	1	0	1	0	0	0	5	0	5	0	8	1	2	2	8	1	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:79176070C>A	uc002jzp.1	-	7	958	c.758G>T	c.(757-759)CGG>CTG	p.R253L	AZI1_uc002jzn.1_Missense_Mutation_p.R253L|AZI1_uc002jzo.1_Missense_Mutation_p.R253L|AZI1_uc010wum.1_Missense_Mutation_p.R253L	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	253					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CACCTCCTTCCGCCTGGGCAA	0.652													16	48					1.15088e-07	2.08863e-07	1	0	A	79176070	A	A	79176070	3	1	166	1	0	0	0	0	1	0	0	0	1242	652	23	3	2564	3	AZI1	17	79176070	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2975101	79176070	2019140	904	31232											
SLC16A3	9123	broad.mit.edu	37	chr17	80195732	80195732	+	Frame_Shift_Del	DEL	G	-	-																															attggcctggtgctgctgatGgaggcggtggccgtgctcgt																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:80195732delG	uc002kea.2	+	4	1225	c.1086delG	c.(1084-1086)ATGfs	p.M362fs	SLC16A3_uc002kee.2_Frame_Shift_Del_p.M362fs|SLC16A3_uc002keb.2_Frame_Shift_Del_p.M362fs|SLC16A3_uc002kec.2_Frame_Shift_Del_p.M362fs|SLC16A3_uc002ked.2_Frame_Shift_Del_p.M362fs	NM_001042422	NP_001035887	O15427	MOT4_HUMAN	solute carrier family 16, member 3	362	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			upper_aerodigestive_tract(1)|lung(1)	2	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	TGCTGCTGATGGAGGCGGTGG	0.682													---	---	---								-	80195732	-	-	80195732	7	5	166	1	0	1	0	1	0	0	0	0	14474	1348	47	0	1096	0	SLC16A3	17	80195732	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	1019662	80195732	999478	905	31233											
FN3K	64122	broad.mit.edu	37	chr17	80699208	80699208	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaagaggtgagggtgctgAgcctcagtatgtggacaagt	10	8	16	7	1	1	3	1	2	0	1	1	5	1	4	2	3	2	2	2	3	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:80699208A>T	uc010wvs.1	+	4	468	c.407A>T	c.(406-408)GAG>GTG	p.E136V	FN3K_uc002kfw.1_Missense_Mutation_p.E91V	NM_022158	NP_071441	Q9H479	FN3K_HUMAN	fructosamine 3 kinase	136					fructoselysine metabolic process		fructosamine-3-kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			GAGGGTGCTGAGCCTCAGTAT	0.552													8	9					0	0	0	0	T	80699208	T	T	80699208	3	4	166	1	0	0	0	0	1	0	0	0	5995	304	11	5	421	5	FN3K	17	80699208	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	503476	80699208	496002	906	31234											
TBCD	6904	broad.mit.edu	37	chr17	80885196	80885196	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcagaggggacgtgggcaCctggtacgtacgtagcagtg	9	6	17	9	3	0	1	0	0	0	1	0	2	0	2	1	4	4	6	1	4	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:80885196C>T	uc002kfz.2	+	29	2736	c.2606C>T	c.(2605-2607)ACC>ATC	p.T869I	TBCD_uc002kfy.1_Missense_Mutation_p.T869I|TBCD_uc002kgb.1_Missense_Mutation_p.T194I|TBCD_uc002kgc.2_Missense_Mutation_p.T14I|TBCD_uc002kgd.2_5'Flank	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	869					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			GACGTGGGCACCTGGTACGTA	0.572													6	15					0	0	0	0	T	80885196	T	T	80885196	3	4	166	1	0	0	0	0	1	0	0	0	15699	507	18	4	2720	4	TBCD	17	80885196	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	185988	80885196	310014	907	31235											
CETN1	1068	broad.mit.edu	37	chr18	580859	580859	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatgatcgacgaagctgatCgggatggggacggcgaagtg	11	6	18	6	5	0	3	0	2	0	1	2	8	0	5	0	4	1	1	0	4	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:580859C>T	uc002kko.1	+	1	493	c.451C>T	c.(451-453)CGG>TGG	p.R151W		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	151	2 (Probable).|EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2						CGAAGCTGATCGGGATGGGGA	0.547													46	173					0	0	0	0	T	580859	T	T	580859	3	4	166	1	0	0	0	0	1	0	0	0	3289	875	31	1	453	1	CETN1	18	580859	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08		580859	77496389	908	31236											
TMEM200C	645369	broad.mit.edu	37	chr18	5891787	5891787	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggacccggtggctgctgccCgcaggcggcagctgcttacc	4	6	16	15	3	0	0	0	0	0	0	0	1	0	1	3	5	5	6	3	5	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:5891787C>T	uc002kmx.1	-	1	317	c.276G>A	c.(274-276)GCG>GCA	p.A92A		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	92						integral to membrane					0						GGCTGCTGCCCGCAGGCGGCA	0.672													12	131					0	0	0	0	T	5891787	T	T	5891787	2	4	166	1	0	0	0	0	0	0	0	1	16191	639	23	1		1	TMEM200C	18	5891787	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5310928	5891787	72185461	909	31237											
ARHGAP28	79822	broad.mit.edu	37	chr18	6876197	6876197	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcgactttcaggatgtactgCtaaagtcaaggtaccgaaca	13	10	9	9	2	2	0	2	0	0	0	3	3	2	1	1	2	4	3	1	2	6	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:6876197C>A	uc010wzi.1	+	9	987	c.749C>A	c.(748-750)GCT>GAT	p.A250D	ARHGAP28_uc002knc.2_Missense_Mutation_p.A375D|ARHGAP28_uc002knd.2_Missense_Mutation_p.A268D|ARHGAP28_uc002kne.2_Missense_Mutation_p.A268D|ARHGAP28_uc002knf.2_Missense_Mutation_p.A259D			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	250					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				GGATGTACTGCTAAAGTCAAG	0.388													65	63					5.26073e-25	1.28247e-24	1	0	A	6876197	A	A	6876197	3	1	166	1	0	0	0	0	1	0	0	0	877	797	28	4	833	4	ARHGAP28	18	6876197	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	984410	6876197	71201051	910	31238											
LAMA1	284217	broad.mit.edu	37	chr18	7024446	7024446	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacttcatctccatcattgaGgtggcaggtggggctgaaac	9	10	12	10	0	3	2	2	2	1	0	4	2	3	2	1	5	1	2	1	5	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:7024446G>A	uc002knm.2	-	18	2516	c.2422C>T	c.(2422-2424)CTC>TTC	p.L808F	LAMA1_uc010wzj.1_Missense_Mutation_p.L284F	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	808	Laminin EGF-like 7.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCATCATTGAGGTGGCAGGTG	0.438													8	73					0	0	0	0	A	7024446	A	A	7024446	3	1	166	1	0	0	0	0	1	0	0	0	8645	1000	35	4	6989	4	LAMA1	18	7024446	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	148249	7024446	71052802	911	31239											
PTPRM	5797	broad.mit.edu	37	chr18	8379247	8379247	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaccatgagaaaaaccggtGcatggacatcctgcccccag	13	5	10	13	1	0	1	0	1	0	1	1	4	1	2	5	2	4	1	5	2	3	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:8379247G>T	uc002knn.3	+	26	4159	c.3656G>T	c.(3655-3657)TGC>TTC	p.C1219F	PTPRM_uc010dkv.2_Missense_Mutation_p.C1232F|PTPRM_uc010wzl.1_Missense_Mutation_p.C1006F	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1219	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				AAAAACCGGTGCATGGACATC	0.567													35	153					1.07637e-12	2.18846e-12	1	0	T	8379247	T	T	8379247	3	4	166	1	0	0	0	0	1	0	0	0	12871	1319	46	4	3805	4	PTPRM	18	8379247	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1354801	8379247	69698001	912	31240											
TXNDC2	84203	broad.mit.edu	37	chr18	9887082	9887082	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aagtcctcagaagaagccatCcagcccaaagagggtgacat	15	5	10	11	0	1	4	1	1	0	3	3	4	3	4	4	1	2	0	4	1	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:9887082C>G	uc002koi.3	+	2	1055	c.606C>G	c.(604-606)ATC>ATG	p.I202M	TXNDC2_uc010wzq.1_Intron|TXNDC2_uc002koh.3_Missense_Mutation_p.I135M	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	202	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.|6.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						AAGAAGCCATCCAGCCCAAAG	0.577													55	534					0	0	0	0	G	9887082	G	G	9887082	3	3	166	1	0	0	0	0	1	0	0	0	16865	845	30	2	612	2	TXNDC2	18	9887082	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1507835	9887082	68190166	913	31241											
FAM38B	63895	broad.mit.edu	37	chr18	10672752	10672752	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgaagaccaccagttccagGgcctgagagttcggattgta	10	10	12	9	1	0	3	0	2	0	2	2	5	1	4	4	2	0	3	4	2	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:10672752G>C	uc002kor.3	-	13	1952	c.1812C>G	c.(1810-1812)GCC>GCG	p.A604A	FAM38B_uc002koq.2_Silent_p.A439A	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2647						integral to membrane	ion channel activity			ovary(1)	1						CCAGTTCCAGGGCCTGAGAGT	0.448													34	288					0	0	0	0	C	10672752	C	C	10672752	2	2	166	1	0	0	0	0	0	0	0	1	5587	1219	43	4		4	FAM38B	18	10672752	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	785670	10672752	67404496	914	31242											
MC5R	4161	broad.mit.edu	37	chr18	13826509	13826509	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgctgggcgtgtttaccGtgtgctgggccccgttcttc	1	14	14	12	3	1	0	0	0	1	0	2	0	1	0	3	2	4	5	3	2	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:13826509G>A	uc010xaf.1	+	1	745	c.745G>A	c.(745-747)GTG>ATG	p.V249M		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	249	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						CGTGTTTACCGTGTGCTGGGC	0.587													50	417					0	0	0	0	A	13826509	A	A	13826509	3	1	166	1	0	0	0	0	1	0	0	0	9420	1145	40	1	747	1	MC5R	18	13826509	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3153757	13826509	64250739	915	31243											
ZNF519	162655	broad.mit.edu	37	chr18	14105881	14105881	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgagtaagctttgagaatgGgtcagaagtttcaccacatt	12	13	10	6	0	2	3	2	2	0	2	2	4	2	3	1	1	1	3	1	1	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:14105881G>A	uc002kst.1	-	3	811	c.658C>T	c.(658-660)CCA>TCA	p.P220S	ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTTGAGAATGGGTCAGAAGTT	0.299													15	167					0	0	0	0	A	14105881	A	A	14105881	3	1	166	1	0	0	0	0	1	0	0	0	18031	1232	43	4	968	4	ZNF519	18	14105881	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	279372	14105881	63971367	916	31244											
ANKRD30B	374860	broad.mit.edu	37	chr18	14752966	14752966	+	Frame_Shift_Del	DEL	G	-	-																															agtgagaatttgttaatggtGgcaacactgctgtcctatgg																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:14752966delG	uc010dlo.2	+	3	645	c.465delG	c.(463-465)GTGfs	p.V155fs	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	155	ANK 3.									ovary(1)|skin(1)	2						TGTTAATGGTGGCAACACTGC	0.363													---	---	---								-	14752966	-	-	14752966	7	5	166	1	0	1	0	1	0	0	0	0	659	1335	47	0	475	0	ANKRD30B	18	14752966	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	647085	14752966	63324282	917	31245											
ANKRD30B	374860	broad.mit.edu	37	chr18	14822494	14822494	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttttagagtctcctgataAagatggtcttctgaaggtaa	11	15	9	6	0	4	4	0	2	4	2	5	4	4	4	1	2	0	1	1	2	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:14822494A>T	uc010dlo.2	+	25	2477	c.2297A>T	c.(2296-2298)AAA>ATA	p.K766I		NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	851										ovary(1)|skin(1)	2						TCTCCTGATAAAGATGGTCTT	0.274													7	65					0	0	0	0	T	14822494	T	T	14822494	3	4	166	1	0	0	0	0	1	0	0	0	659	14	1	5	2395	5	ANKRD30B	18	14822494	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	69528	14822494	63254754	918	31246											
ROCK1	6093	broad.mit.edu	37	chr18	18572799	18572799	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaaatcatttaccttttctGagtgattaagcatgtcttga	11	18	6	6	0	3	3	1	3	2	0	3	3	3	3	1	0	2	1	1	0	4	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:18572799G>A	uc002kte.2	-	17	2926	c.1985C>T	c.(1984-1986)TCA>TTA	p.S662L		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	662	Glu-rich.|Interaction with FHOD1.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TACCTTTTCTGAGTGATTAAG	0.303													20	20					0	0	0	0	A	18572799	A	A	18572799	3	1	166	1	0	0	0	0	1	0	0	0	13582	1294	45	2	2147	2	ROCK1	18	18572799	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3750305	18572799	59504449	919	31247											
ASXL3	80816	broad.mit.edu	37	chr18	31319219	31319219	+	Frame_Shift_Del	DEL	C	-	-																															acgtccttttcttctgagagCccagagggagcctgtaccag																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:31319219delC	uc010dmg.1	+	11	1906	c.1851delC	c.(1849-1851)AGCfs	p.S617fs	ASXL3_uc002kxq.2_Frame_Shift_Del_p.S324fs	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	617	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CTTCTGAGAGCCCAGAGGGAG	0.473													---	---	---								-	31319219	-	-	31319219	7	5	166	1	0	1	0	1	0	0	0	0	1070	738	26	0	1893	0	ASXL3	18	31319219	Frame_Shift_Del	DEL	C	TCGA-CR-7402-01A-11D-2012-08	12746420	31319219	46758029	920	31248											
ASXL3	80816	broad.mit.edu	37	chr18	31323688	31323688	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagggaactgacactccatgCatagccattataccaaaatg	15	8	7	11	0	0	1	0	1	0	0	1	2	1	2	3	1	4	1	3	1	6	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:31323688C>A	uc010dmg.1	+	12	3931	c.3876C>A	c.(3874-3876)TGC>TGA	p.C1292*	ASXL3_uc002kxq.2_Nonsense_Mutation_p.C999*	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1292	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ACACTCCATGCATAGCCATTA	0.393													68	53					1.72039e-30	4.26831e-30	1	0	A	31323688	A	A	31323688	4	1	166	1	0	0	0	0	0	1	0	0	1070	718	25	4	3922	4	ASXL3	18	31323688	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4469	31323688	46753560	921	31249											
SLC14A2	8170	broad.mit.edu	37	chr18	43253684	43253684	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctttgactccatctactTcggcctgtgtggcttcaaca	6	13	8	14	1	2	1	1	1	1	0	4	1	3	1	3	2	2	1	3	2	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:43253684T>A	uc010dnj.2	+	19	2735	c.2414T>A	c.(2413-2415)TTC>TAC	p.F805Y	SLC14A2_uc002lbe.2_Missense_Mutation_p.F805Y	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	805	Helical; (Potential).					apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TCCATCTACTTCGGCCTGTGT	0.587													41	32					0	0	0	0	A	43253684	A	A	43253684	3	1	166	1	0	0	0	0	1	0	0	0	14462	1783	62	5	2480	5	SLC14A2	18	43253684	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	11929996	43253684	34823564	922	31250											
TCEB3B	51224	broad.mit.edu	37	chr18	44560992	44560992	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcacaacggctttcccctggGgttggccctggcagcctgga	5	9	13	14	1	1	0	1	0	0	0	2	1	2	1	4	6	2	3	4	6	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:44560992G>T	uc002lcr.1	-	1	997	c.644C>A	c.(643-645)CCC>CAC	p.P215H	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	215					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TTTCCCCTGGGGTTGGCCCTG	0.662													22	9					2.00529e-23	4.85231e-23	1	0	T	44560992	T	T	44560992	3	4	166	1	0	0	0	0	1	0	0	0	15748	1232	43	4	1621	4	TCEB3B	18	44560992	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1307308	44560992	33516256	923	31251											
ME2	4200	broad.mit.edu	37	chr18	48439273	48439273	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaattgtatatacaccgacGgttggtcttgcctgctccca	8	12	8	13	2	1	0	0	0	1	0	2	1	2	0	4	2	3	3	4	2	4	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:48439273G>T	uc002ley.2	+	4	601	c.345G>T	c.(343-345)ACG>ACT	p.T115T	ME2_uc010dpd.2_Silent_p.T115T	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	115					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	ATACACCGACGGTTGGTCTTG	0.323													66	54					1.1794e-34	2.96363e-34	1	0	T	48439273	T	T	48439273	2	4	166	1	0	0	0	0	0	0	0	1	9471	1103	39	3		3	ME2	18	48439273	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3878281	48439273	29637975	924	31252											
DCC	1630	broad.mit.edu	37	chr18	51013297	51013297	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccattcccaacactctcagtGgaccgaggtttcggagcagg	9	8	11	13	2	1	0	1	0	1	0	4	3	2	2	3	4	2	2	3	4	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:51013297G>T	uc002lfe.1	+	26	4454	c.3867G>T	c.(3865-3867)GTG>GTT	p.V1289V	DCC_uc010dpf.1_Silent_p.V924V	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1289	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CACTCTCAGTGGACCGAGGTT	0.473													42	35					2.26627e-22	5.41695e-22	1	0	T	51013297	T	T	51013297	2	4	166	1	0	0	0	0	0	0	0	1	4299	1335	47	4		4	DCC	18	51013297	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2574024	51013297	27063951	925	31253											
CDH20	28316	broad.mit.edu	37	chr18	59203814	59203814	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacagcaagacccctagacCgggaagaattttcttggcat	12	9	10	10	1	1	4	0	1	1	3	1	5	1	5	3	2	1	2	3	2	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:59203814C>T	uc010dps.1	+	7	1372	c.1360C>T	c.(1360-1362)CGG>TGG	p.R454W	CDH20_uc002lif.2_Missense_Mutation_p.R448W	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	454	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				ACCCCTAGACCGGGAAGAATT	0.408													52	55					0	0	0	0	T	59203814	T	T	59203814	3	4	166	1	0	0	0	0	1	0	0	0	3121	643	23	1	1386	1	CDH20	18	59203814	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8190517	59203814	18873434	926	31254											
CD226	10666	broad.mit.edu	37	chr18	67562961	67562961	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctacagtcaatctcatcaCgaaggtttcgttttctcctg	8	14	8	11	2	4	0	3	0	2	0	7	1	4	0	1	2	1	3	1	2	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:67562961C>A	uc010dqo.2	-	3	1150	c.703G>T	c.(703-705)GTG>TTG	p.V235L	CD226_uc002lkm.3_Missense_Mutation_p.V235L	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	235	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				AATCTCATCACGAAGGTTTCG	0.532													84	72					1.29045e-55	3.28478e-55	1	0	A	67562961	A	A	67562961	3	1	166	1	0	0	0	0	1	0	0	0	3001	536	19	3	323	3	CD226	18	67562961	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	8359147	67562961	10514287	927	31255											
NETO1	81832	broad.mit.edu	37	chr18	70417315	70417315	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgctggacggctttatcgTgtctggacagcctgtgactg	6	11	13	11	3	1	1	0	1	1	0	2	3	1	3	2	3	1	2	2	3	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:70417315T>A	uc002lkw.2	-	9	1807	c.1523A>T	c.(1522-1524)CAC>CTC	p.H508L	NETO1_uc002lkx.1_Missense_Mutation_p.H507L|NETO1_uc002lky.1_Missense_Mutation_p.H508L	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	508	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GGCTTTATCGTGTCTGGACAG	0.438													26	25					0	0	0	0	A	70417315	A	A	70417315	3	1	166	1	0	0	0	0	1	0	0	0	10393	1696	59	5	86	5	NETO1	18	70417315	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2854354	70417315	7659933	928	31256											
CDC34	997	broad.mit.edu	37	chr19	541375	541375	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaaggtggacgcggagcgTgacggcgtgaaggtgcccac	9	4	17	11	5	0	2	0	2	0	0	0	4	0	4	2	5	2	0	2	5	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:541375T>C	uc002lov.2	+	5	733	c.534T>C	c.(532-534)CGT>CGC	p.R178R	GZMM_uc002low.1_5'Flank	NM_004359	NP_004350	P49427	UB2R1_HUMAN	ubiquitin-conjugating enzyme Cdc34	178					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity				0		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCGGAGCGTGACGGCGTGA	0.706													6	11					0	0	0	0	C	541375	C	C	541375	2	2	166	1	0	0	0	0	0	0	0	1	3082	1683	59	5		5	CDC34	19	541375	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08		541375	58587608	929	31257											
PALM	5064	broad.mit.edu	37	chr19	746513	746513	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggccacgtccggcccgcCggggatccagcccggccagg	5	2	16	18	6	0	0	0	0	0	0	2	2	2	1	7	6	1	0	7	6	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:746513C>A	uc002lpm.1	+	9	1057	c.863C>A	c.(862-864)CCG>CAG	p.P288Q	PALM_uc002lpn.1_Missense_Mutation_p.P244Q|PALM_uc010xfu.1_Missense_Mutation_p.P153Q	NM_002579	NP_002570	O75781	PALM_HUMAN	paralemmin isoform 1	288					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane					0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		TCCGGCCCGCCGGGGATCCAG	0.697													10	40					3.86212e-05	6.52565e-05	1	0	A	746513	A	A	746513	3	1	166	1	0	0	0	0	1	0	0	0	11462	652	23	3	897	3	PALM	19	746513	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	205138	746513	58382470	930	31258											
DIRAS1	148252	broad.mit.edu	37	chr19	2717513	2717513	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gatgagcttgtagatgggccCcagctcctccagcgactgct	7	9	12	13	1	0	2	0	1	0	1	2	4	2	2	4	1	4	4	4	1	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:2717513C>T	uc002lwf.3	-	2	450	c.292G>A	c.(292-294)GGG>AGG	p.G98R		NM_145173	NP_660156	O95057	DIRA1_HUMAN	DIRAS family, GTP-binding RAS-like 1	98					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGATGGGCCCCAGCTCCTCC	0.627													17	26					0	0	0	0	T	2717513	T	T	2717513	3	4	166	1	0	0	0	0	1	0	0	0	4552	623	22	4	308	4	DIRAS1	19	2717513	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1971000	2717513	56411470	931	31259											
TLE2	7089	broad.mit.edu	37	chr19	3015720	3015720	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagggccactcggtcgctcCtcctccacgagactctcagg	6	7	10	18	3	1	1	1	0	1	1	7	2	4	1	5	3	0	1	5	3	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:3015720C>G	uc002lww.2	-	9	872	c.609G>C	c.(607-609)GAG>GAC	p.E203D	TLE2_uc010xhb.1_5'UTR|TLE2_uc010dth.2_Missense_Mutation_p.E204D|TLE2_uc010xhc.1_Missense_Mutation_p.E81D|TLE2_uc010dti.2_Missense_Mutation_p.E217D|TLE2_uc010xhd.1_Missense_Mutation_p.E111D	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	203	CCN domain.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGTCGCTCCTCCTCCACGA	0.632													8	12					0	0	0	0	G	3015720	G	G	3015720	3	3	166	1	0	0	0	0	1	0	0	0	16005	680	24	4	1670	4	TLE2	19	3015720	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	298207	3015720	56113263	932	31260											
PIP5K1C	23396	broad.mit.edu	37	chr19	3653452	3653452	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtaggtggagcccttgaggtCgaacttgaggtgcatcttga	8	11	15	7	1	1	3	0	3	1	0	2	5	1	4	1	4	3	2	1	4	2	4	rs121908315		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:3653452C>G	uc002lyj.1	-	7	814	c.757G>C	c.(757-759)GAC>CAC	p.D253H	PIP5K1C_uc010xhq.1_Missense_Mutation_p.D253H|PIP5K1C_uc010xhr.1_Missense_Mutation_p.D253H	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	253	PIPK.		D -> N (in LCCS3; loss of activity).		axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		CCCTTGAGGTCGAACTTGAGG	0.587													21	61					0	0	0	0	G	3653452	G	G	3653452	3	3	166	1	0	0	0	0	1	0	0	0	11996	884	31	3	1297	3	PIP5K1C	19	3653452	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	637732	3653452	55475531	933	31261											
ZBTB7A	51341	broad.mit.edu	37	chr19	4054160	4054160	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acgtcgccgtcgtgggcgccGctgaagtacttcaggtagta	7	9	14	11	6	1	1	1	1	0	0	3	1	1	1	2	2	1	4	2	2	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:4054160G>T	uc002lzh.2	-	2	1146	c.1071C>A	c.(1069-1071)AGC>AGA	p.S357R	ZBTB7A_uc002lzi.2_Missense_Mutation_p.S357R	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	357					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTGGGCGCCGCTGAAGTACT	0.537													20	44					7.41877e-09	1.39013e-08	1	0	T	4054160	T	T	4054160	3	4	166	1	0	0	0	0	1	0	0	0	17620	1078	38	3	691	3	ZBTB7A	19	4054160	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	400708	4054160	55074823	934	31262											
ZBTB7A	51341	broad.mit.edu	37	chr19	4054266	4054266	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccaccgatgacatcatcTgctgcagcagcgtgctggcc	7	7	12	15	2	2	1	1	1	1	0	2	2	2	1	3	2	5	4	3	2	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:4054266T>A	uc002lzh.2	-	2	1040	c.965A>T	c.(964-966)CAG>CTG	p.Q322L	ZBTB7A_uc002lzi.2_Missense_Mutation_p.Q322L	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	322					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		TGACATCATCTGCTGCAGCAG	0.602													4	15					0	0	0	0	A	4054266	A	A	4054266	3	1	166	1	0	0	0	0	1	0	0	0	17620	1580	55	5	797	5	ZBTB7A	19	4054266	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	106	4054266	55074717	935	31263											
ARRDC5	645432	broad.mit.edu	37	chr19	4891178	4891178	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccttgaggctggtcagggaCcagggcaggtgcacggtggt	6	7	19	9	1	1	1	1	1	0	0	1	2	1	2	2	7	1	3	2	7	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:4891178C>A	uc002mbm.2	-	3	909	c.909G>T	c.(907-909)TGG>TGT	p.W303C		NM_001080523	NP_001073992	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	303					signal transduction						0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		TGGTCAGGGACCAGGGCAGGT	0.607													52	132					2.30037e-20	5.3932e-20	1	0	A	4891178	A	A	4891178	3	1	166	1	0	0	0	0	1	0	0	0	988	508	18	4	123	4	ARRDC5	19	4891178	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	836912	4891178	54237805	936	31264											
KDM4B	23030	broad.mit.edu	37	chr19	5082396	5082396	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agatcacgcaggaggccgggGaattcatgatcacatttccc	11	8	11	11	2	3	2	3	1	0	1	4	4	4	4	2	4	0	1	2	4	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:5082396G>T	uc002mbq.3	+	9	1025	c.799G>T	c.(799-801)GAA>TAA	p.E267*	KDM4B_uc010xil.1_Nonsense_Mutation_p.E267*|KDM4B_uc010xim.1_Nonsense_Mutation_p.E267*|KDM4B_uc002mbr.3_Nonsense_Mutation_p.E25*	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	267	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						GGAGGCCGGGGAATTCATGAT	0.597													11	23					9.70103e-10	1.86962e-09	1	0	T	5082396	T	T	5082396	4	4	166	1	0	0	0	0	0	1	0	0	8168	1175	41	2	825	2	KDM4B	19	5082396	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	191218	5082396	54046587	937	31265											
C3	718	broad.mit.edu	37	chr19	6686804	6686804	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaagaggccccttcagcctgCccatctgggccagagcatag	9	6	12	14	0	2	2	1	0	1	2	2	3	2	2	5	2	3	1	5	2	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:6686804C>G	uc002mfm.2	-	28	3661	c.3599G>C	c.(3598-3600)GGC>GCC	p.G1200A	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1200					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTTCAGCCTGCCCATCTGGGC	0.542													71	163					0	0	0	0	G	6686804	G	G	6686804	3	3	166	1	0	0	0	0	1	0	0	0	2214	739	26	4	1448	4	C3	19	6686804	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1604408	6686804	52442179	938	31266											
TIMM44	10469	broad.mit.edu	37	chr19	7999066	7999066	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttggccgtcttggctgcttCctccacgccctccttgattt	2	15	8	16	2	1	1	0	1	1	0	4	1	4	1	5	2	1	2	5	2	0	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:7999066C>A	uc002miz.2	-	5	453	c.451G>T	c.(451-453)GAA>TAA	p.E151*	TIMM44_uc002mja.2_5'UTR|TIMM44_uc010dvx.1_RNA	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	151					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						TTGGCTGCTTCCTCCACGCCC	0.622													32	103					9.93527e-08	1.82162e-07	1	0	A	7999066	A	A	7999066	4	1	166	1	0	0	0	0	0	1	0	0	15978	864	30	2	943	2	TIMM44	19	7999066	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1312262	7999066	51129917	939	31267											
FBN3	84467	broad.mit.edu	37	chr19	8206823	8206824	+	Splice_Site	DNP	CC	AA	AA																															agccctgaccccactattcaCcttggcaggcccccgtgtgg																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:8206823_8206824CC>AA	uc002mjf.2	-	6	760	c.739_splice	c.e6+1	p.D247_splice		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor							proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCACTATTCACCTTGGCAGGCC	0.634													12	48					0	0	0	0	AA	8206824	AA	AA	8206823	5	1	166	1	0	0	0	0	0	0	1	0	5736	521	18	4	7921	4	FBN3	19	8206823	Splice_Site	DNP	CC	TCGA-CR-7402-01A-11D-2012-08	207757	8206823	50922160	940	31268											
MYO1F	4542	broad.mit.edu	37	chr19	8587264	8587264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgccctggtacacacaccttCcatgaggatctcaatgacct	10	10	7	14	0	1	2	1	2	1	0	3	3	2	3	4	2	2	1	4	2	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:8587264C>T	uc002mkg.2	-	27	3331	c.3217G>A	c.(3217-3219)GAA>AAA	p.E1073K		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	1073	SH3.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						CACACACCTTCCATGAGGATC	0.453													12	27					0	0	0	0	T	8587264	T	T	8587264	3	4	166	1	0	0	0	0	1	0	0	0	10126	864	30	2	87	2	MYO1F	19	8587264	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	380441	8587264	50541719	941	31269											
MUC16	94025	broad.mit.edu	37	chr19	9015728	9015728	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaagttgagggtgaacggcaCcaggagagggccagcagctg	11	4	18	8	1	0	3	0	2	0	1	0	5	0	3	2	4	3	4	2	4	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9015728C>A	uc002mkp.2	-	29	38299	c.38095G>T	c.(38095-38097)GTG>TTG	p.V12699L	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12701	SEA 5.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGAACGGCACCAGGAGAGGG	0.458													35	113					0.000109025	0.000182174	1	0	A	9015728	A	A	9015728	3	1	166	1	0	0	0	0	1	0	0	0	10026	507	18	4	5652	4	MUC16	19	9015728	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	428464	9015728	50113255	942	31270											
MUC16	94025	broad.mit.edu	37	chr19	9059286	9059286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggccaggaggctgtgcttGatgagtccaaggtaaaggta	10	9	15	7	0	0	2	0	2	0	0	1	3	1	3	2	5	1	4	2	5	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9059286G>A	uc002mkp.2	-	3	28364	c.28160C>T	c.(28159-28161)TCA>TTA	p.S9387L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9389	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCTGTGCTTGATGAGTCCAA	0.527													35	103					0	0	0	0	A	9059286	A	A	9059286	3	1	166	1	0	0	0	0	1	0	0	0	10026	1294	45	2	15691	2	MUC16	19	9059286	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	43558	9059286	50069697	943	31271											
MUC16	94025	broad.mit.edu	37	chr19	9059658	9059658	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggttgatgtgagaacatttGtatctcctgtggggtaggtg	7	14	16	4	0	1	2	0	2	1	1	2	3	1	2	1	4	1	3	1	4	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9059658G>C	uc002mkp.2	-	3	27992	c.27788C>G	c.(27787-27789)ACA>AGA	p.T9263R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9265	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGAACATTTGTATCTCCTGT	0.473													29	90					0	0	0	0	C	9059658	C	C	9059658	3	2	166	1	0	0	0	0	1	0	0	0	10026	1377	48	4	16063	4	MUC16	19	9059658	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	372	9059658	50069325	944	31272											
MUC16	94025	broad.mit.edu	37	chr19	9071927	9071927	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgtttgtagtctcagaggaAccatgcactggcattgatgt	10	13	11	7	0	1	2	1	1	1	1	2	3	1	3	1	2	2	4	1	2	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9071927A>G	uc002mkp.2	-	3	15723	c.15519T>C	c.(15517-15519)GGT>GGC	p.G5173G		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5175	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTCAGAGGAACCATGCACTG	0.498													70	242					0	0	0	0	G	9071927	G	G	9071927	2	3	166	1	0	0	0	0	0	0	0	1	10026	30	2	5		5	MUC16	19	9071927	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	12269	9071927	50057056	945	31273											
MUC16	94025	broad.mit.edu	37	chr19	9075894	9075894	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgtctgcccttgtctcTgaaaagttgcatctggagtt	7	14	11	9	0	3	1	0	1	3	0	4	3	3	2	1	1	3	4	1	1	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9075894T>A	uc002mkp.2	-	3	11756	c.11552A>T	c.(11551-11553)CAG>CTG	p.Q3851L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3852	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCCTTGTCTCTGAAAAGTTGC	0.502													34	67					0	0	0	0	A	9075894	A	A	9075894	3	1	166	1	0	0	0	0	1	0	0	0	10026	1580	55	5	32299	5	MUC16	19	9075894	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	3967	9075894	50053089	946	31274											
TYK2	7297	broad.mit.edu	37	chr19	10475629	10475629	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggcccacagtggctcccgCggcctgtctgccggctggcc	3	7	14	17	3	1	0	0	0	1	0	2	0	2	0	5	5	1	2	5	5	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:10475629C>T	uc002moc.3	-	8	1485	c.1107G>A	c.(1105-1107)CCG>CCA	p.P369P	TYK2_uc010dxe.2_Silent_p.P184P|TYK2_uc002mod.2_Silent_p.P369P	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	369	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GTGGCTCCCGCGGCCTGTCTG	0.617													20	43					0	0	0	0	T	10475629	T	T	10475629	2	4	166	1	0	0	0	0	0	0	0	1	16878	755	27	1		1	TYK2	19	10475629	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1399735	10475629	48653354	947	31275											
SMARCA4	6597	broad.mit.edu	37	chr19	11144853	11144853	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagatgatcgcccggcacGaggaggagtttgatctgttc	9	9	13	10	3	1	3	0	2	1	1	3	6	1	5	2	3	0	3	2	3	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:11144853G>T	uc002mqf.3	+	28	4212	c.3928G>T	c.(3928-3930)GAG>TAG	p.E1310*	SMARCA4_uc010dxp.2_Nonsense_Mutation_p.E1310*|SMARCA4_uc010dxo.2_Nonsense_Mutation_p.E1310*|SMARCA4_uc010dxq.2_Nonsense_Mutation_p.E1277*|SMARCA4_uc010dxr.2_Nonsense_Mutation_p.E1277*|SMARCA4_uc002mqj.3_Nonsense_Mutation_p.E1277*|SMARCA4_uc010dxs.2_Nonsense_Mutation_p.E1277*|SMARCA4_uc010dxt.1_Nonsense_Mutation_p.E497*|SMARCA4_uc002mqh.3_Nonsense_Mutation_p.E400*|SMARCA4_uc002mqi.1_Nonsense_Mutation_p.E480*	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1310					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.E1310*(2)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CGCCCGGCACGAGGAGGAGTT	0.597			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				24	44					2.21704e-12	4.45681e-12	1	0	T	11144853	T	T	11144853	4	4	166	1	0	0	0	0	0	1	0	0	14834	1059	37	3	4034	3	SMARCA4	19	11144853	Nonsense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	669224	11144853	47984130	948	31276											
ZNF625	90589	broad.mit.edu	37	chr19	12256682	12256682	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtccatctccactgtgcatTatcctgtgtcttcgaatgct	6	15	8	12	1	2	0	0	0	2	0	6	1	4	0	3	1	2	2	3	1	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:12256682T>A	uc002mth.2	-	4	701	c.351A>T	c.(349-351)ATA>ATT	p.I117I	ZNF20_uc002mtg.1_Intron|ZNF625_uc010dyn.1_RNA|ZNF625_uc010dyo.1_Silent_p.I151I	NM_145233	NP_660276	Q96I27	ZN625_HUMAN	zinc finger protein 625	117	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACTGTGCATTATCCTGTGTC	0.433													32	89					0	0	0	0	A	12256682	A	A	12256682	2	1	166	1	0	0	0	0	0	0	0	1	18116	1744	61	5		5	ZNF625	19	12256682	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1111829	12256682	46872301	949	31277											
MAST1	22983	broad.mit.edu	37	chr19	12951880	12951880	+	Frame_Shift_Del	DEL	G	-	-																															ctcgtttgcctcctcccgaaGgtgagtccctcccctccagg																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:12951880delG	uc002mvm.2	+	3	376	c.248delG	c.(247-249)AGGfs	p.R83fs	MAST1_uc002mvk.2_Frame_Shift_Del_p.R79fs|MAST1_uc002mvl.2_Frame_Shift_Del_p.S83fs	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	83					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						TCCTCCCGAAGGTGAGTCCCT	0.637													---	---	---								-	12951880	-	-	12951880	7	5	166	1	0	1	0	1	0	0	0	0	9377	1014	35	0	258	0	MAST1	19	12951880	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	695198	12951880	46177103	950	31278											
CACNA1A	773	broad.mit.edu	37	chr19	13340911	13340911	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttaccaagctgcggggtcaTactcggcccagacacgcacg	9	6	11	15	4	1	1	1	0	0	1	2	1	1	1	2	3	4	2	2	3	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:13340911T>C	uc010dze.2	-	36	5752	c.5516A>G	c.(5515-5517)TAT>TGT	p.Y1839C	CACNA1A_uc010xnd.1_Missense_Mutation_p.Y544C|CACNA1A_uc002mwx.3_Missense_Mutation_p.Y544C|CACNA1A_uc010dzc.2_Missense_Mutation_p.Y1364C|CACNA1A_uc002mwy.3_Missense_Mutation_p.Y1838C|CACNA1A_uc002mwv.3_Missense_Mutation_p.Y355C	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1839	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGCGGGGTCATACTCGGCCCA	0.587													9	13					0	0	0	0	C	13340911	C	C	13340911	3	2	166	1	0	0	0	0	1	0	0	0	2550	1406	49	5	2156	5	CACNA1A	19	13340911	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	389031	13340911	45788072	951	31279											
RFX1	5989	broad.mit.edu	37	chr19	14094399	14094399	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgtctcgctggcccgcaTggcaccttctgtggggaggg	4	9	15	13	2	2	0	0	0	2	0	3	1	2	1	2	5	0	3	2	5	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:14094399T>G	uc002mxv.2	-	3	600	c.328A>C	c.(328-330)ATG>CTG	p.M110L	RFX1_uc010dzi.2_Missense_Mutation_p.M110L	NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	110					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CTGGCCCGCATGGCACCTTCT	0.672													3	10					0	0	0	0	G	14094399	G	G	14094399	3	3	166	1	0	0	0	0	1	0	0	0	13327	1464	51	5	2687	5	RFX1	19	14094399	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	753488	14094399	45034584	952	31280											
CYP4F22	126410	broad.mit.edu	37	chr19	15651434	15651434	+	Frame_Shift_Del	DEL	G	-	-																															cactgaagtcatccaggaacGgcggcgggcactgcgtcagc																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:15651434delG	uc002nbh.3	+	8	1012	c.845delG	c.(844-846)CGGfs	p.R282fs		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	282						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						ATCCAGGAACGGCGGCGGGCA	0.617													---	---	---								-	15651434	-	-	15651434	7	5	166	1	0	1	0	1	0	0	0	0	4206	1116	39	0	867	0	CYP4F22	19	15651434	Frame_Shift_Del	DEL	G	TCGA-CR-7402-01A-11D-2012-08	1557035	15651434	43477549	953	31281											
ZNF99	7652	broad.mit.edu	37	chr19	22940748	22940748	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccacttaaaagctttacCacattcttcacatttgtagg	12	13	6	10	0	2	0	1	0	1	0	2	1	2	1	2	2	2	2	2	2	4	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:22940748C>T	uc010xrh.1	-	5	1690	c.1690G>A	c.(1690-1692)GGT>AGT	p.G564S		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAAGCTTTACCACATTCTTCA	0.378													11	49					0	0	0	0	T	22940748	T	T	22940748	3	4	166	1	0	0	0	0	1	0	0	0	18271	594	21	4	1434	4	ZNF99	19	22940748	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	7289314	22940748	36188235	954	31282											
ZNF99	7652	broad.mit.edu	37	chr19	22941185	22941186	+	Frame_Shift_Ins	INS	-	A	A																															gccacattcttcacatttgcINSaaggtttctcttccatatga																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:22941185_22941186insA	uc010xrh.1	-	5	1252_1253	c.1252_1253insT	c.(1252-1254)TGCfs	p.C418fs		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTCACATTTGCAAGGTTTCTCT	0.351													---	---	---								A	22941186	A	A	22941185	7	5	166	1	0	1	1	0	0	0	0	0	18271	710	25	0	1871	0	ZNF99	19	22941185	Frame_Shift_Ins	INS	-	TCGA-CR-7402-01A-11D-2012-08	437	22941185	36187798	955	31283											
ZNF254	9534	broad.mit.edu	37	chr19	24309076	24309076	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtatgtgtcctcattttgctCaagacctttggccagagcag	8	13	10	10	0	2	2	2	0	0	2	3	2	3	2	3	1	2	3	3	1	2	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:24309076C>T	uc002nru.2	+	4	408	c.274C>T	c.(274-276)CAA>TAA	p.Q92*	ZNF254_uc010xrk.1_Nonsense_Mutation_p.Q7*	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	92					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				TCATTTTGCTCAAGACCTTTG	0.308													7	30					0	0	0	0	T	24309076	T	T	24309076	4	4	166	1	0	0	0	0	0	1	0	0	17865	827	29	2	288	2	ZNF254	19	24309076	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1367891	24309076	34819907	956	31284											
TSHZ3	57616	broad.mit.edu	37	chr19	31769884	31769884	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgcacttcagcaccttcTgggcgtcttccttcccttcc	5	13	6	17	1	3	0	1	0	2	0	6	0	6	0	4	1	2	2	4	1	0	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:31769884T>A	uc002nsy.3	-	2	880	c.815A>T	c.(814-816)CAG>CTG	p.Q272L		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	272					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CAGCACCTTCTGGGCGTCTTC	0.512													44	148					0	0	0	0	A	31769884	A	A	31769884	3	1	166	1	0	0	0	0	1	0	0	0	16692	1580	55	5	2434	5	TSHZ3	19	31769884	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	7460808	31769884	27359099	957	31285											
ZNF507	22847	broad.mit.edu	37	chr19	32844667	32844667	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtcgtcattgctattggaGagagtgaactgagtatccac	11	11	11	8	1	1	3	1	2	0	1	3	5	2	4	1	1	2	2	1	1	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:32844667G>A	uc002nte.2	+	3	1203	c.931G>A	c.(931-933)GAG>AAG	p.E311K	ZNF507_uc002ntc.2_Missense_Mutation_p.E311K|ZNF507_uc010xrn.1_Missense_Mutation_p.E311K|ZNF507_uc002ntd.2_Missense_Mutation_p.E311K	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					TGCTATTGGAGAGAGTGAACT	0.473													47	159					0	0	0	0	A	32844667	A	A	32844667	3	1	166	1	0	0	0	0	1	0	0	0	18020	943	33	2	933	2	ZNF507	19	32844667	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1074783	32844667	26284316	958	31286											
FXYD3	5349	broad.mit.edu	37	chr19	35613703	35613703	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caggttggcgggctcatctgCgctggggttctgtgcgccat	3	11	16	11	3	3	0	1	0	2	0	3	0	3	0	1	5	2	4	1	5	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:35613703C>G	uc010xsn.1	+	7	458	c.132C>G	c.(130-132)TGC>TGG	p.C44W	FXYD3_uc010xsl.1_Missense_Mutation_p.C44W|FXYD3_uc010xsm.1_Missense_Mutation_p.C101W|FXYD3_uc002nxw.2_Missense_Mutation_p.C44W|FXYD3_uc002nxv.2_Missense_Mutation_p.C44W|FXYD3_uc010xso.1_Missense_Mutation_p.C44W	NM_001136011	NP_001129483	Q14802	FXYD3_HUMAN	FXYD domain containing ion transport regulator 3	44	Helical; (Potential).					chloride channel complex|integral to plasma membrane	chloride channel activity				0	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GGCTCATCTGCGCTGGGGTTC	0.637													32	75					0	0	0	0	G	35613703	G	G	35613703	3	3	166	1	0	0	0	0	1	0	0	0	6153	776	27	3	414	3	FXYD3	19	35613703	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2769036	35613703	23515280	959	31287											
KIRREL2	84063	broad.mit.edu	37	chr19	36357124	36357124	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagccttggcgaagccccTggaggaggtctcttcctgcc	5	9	13	14	1	1	1	0	1	1	0	3	4	2	3	5	4	3	0	5	4	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:36357124T>C	uc002ocb.3	+	15	2069	c.1857T>C	c.(1855-1857)CCT>CCC	p.P619P	KIRREL2_uc002obz.3_Intron|KIRREL2_uc002oca.3_Intron|KIRREL2_uc002occ.3_Silent_p.P566P|KIRREL2_uc002ocd.3_Silent_p.P581P|APLP1_uc010xsz.1_5'Flank|APLP1_uc002oce.2_5'Flank|APLP1_uc002ocf.2_5'Flank|APLP1_uc002ocg.2_5'Flank	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	619	Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCGAAGCCCCTGGAGGAGGTC	0.607													20	88					0	0	0	0	C	36357124	C	C	36357124	2	2	166	1	0	0	0	0	0	0	0	1	8364	1567	55	5		5	KIRREL2	19	36357124	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	743421	36357124	22771859	960	31288											
ZNF540	163255	broad.mit.edu	37	chr19	38103945	38103945	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagaatgtgggaaggccttTagtcgtagtgtagaccttag	12	11	13	5	1	0	2	0	0	0	2	1	3	0	3	2	2	0	2	2	2	7	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:38103945T>A	uc002ogq.2	+	5	2096	c.1764T>A	c.(1762-1764)TTT>TTA	p.F588L	ZNF540_uc002ogu.2_Missense_Mutation_p.F588L|ZNF540_uc010efq.2_Missense_Mutation_p.F556L	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	588	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGAAGGCCTTTAGTCGTAGTG	0.408													18	51					0	0	0	0	A	38103945	A	A	38103945	3	1	166	1	0	0	0	0	1	0	0	0	18042	1751	61	5	1778	5	ZNF540	19	38103945	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1746821	38103945	21025038	961	31289											
RYR1	6261	broad.mit.edu	37	chr19	38956797	38956797	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacgtgcggctgacgccggcGcagacgacactggtggaccg	7	4	16	14	7	0	2	0	1	0	1	0	4	0	3	2	4	1	2	2	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:38956797G>C	uc002oit.2	+	24	3067	c.2937G>C	c.(2935-2937)GCG>GCC	p.A979A	RYR1_uc002oiu.2_Silent_p.A979A	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	979	2.|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGACGCCGGCGCAGACGACAC	0.652													7	18					0	0	0	0	C	38956797	C	C	38956797	2	2	166	1	0	0	0	0	0	0	0	1	13833	1074	38	3		3	RYR1	19	38956797	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	852852	38956797	20172186	962	31290											
HIPK4	147746	broad.mit.edu	37	chr19	40886623	40886623	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggtcatccagctggtcgatGgctctttgcatacctggtgc	6	12	12	11	1	2	0	1	0	1	0	4	1	3	0	2	4	4	3	2	4	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:40886623G>T	uc002onp.2	-	3	1560	c.1275C>A	c.(1273-1275)GCC>GCA	p.A425A		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	425						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			GCTGGTCGATGGCTCTTTGCA	0.617													41	79					9.85521e-28	2.41755e-27	1	0	T	40886623	T	T	40886623	2	4	166	1	0	0	0	0	0	0	0	1	7158	1335	47	4		4	HIPK4	19	40886623	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1929826	40886623	18242360	963	31291											
CYP2B6	1555	broad.mit.edu	37	chr19	41516003	41516003	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accagcaccactctccgctaCggcttcctgctcatgctcaa	8	9	6	18	2	3	0	2	0	1	0	5	0	4	0	4	1	4	5	4	1	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:41516003C>T	uc002opr.1	+	6	934	c.927C>T	c.(925-927)TAC>TAT	p.Y309Y	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	309					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CTCTCCGCTACGGCTTCCTGC	0.562													14	68					0	0	0	0	T	41516003	T	T	41516003	2	4	166	1	0	0	0	0	0	0	0	1	4181	547	19	1		1	CYP2B6	19	41516003	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	629380	41516003	17612980	964	31292											
CEACAM7	1087	broad.mit.edu	37	chr19	42190981	42190981	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tattttttacatatcctataAttcgatagttggcatgcacc	11	17	5	8	1	0	0	0	0	0	0	2	1	1	0	2	1	2	3	2	1	6	10			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:42190981A>T	uc002ori.1	-	2	238	c.236T>A	c.(235-237)ATT>AAT	p.I79N	CEACAM7_uc010ehx.2_Missense_Mutation_p.I79N|CEACAM7_uc010ehy.1_Missense_Mutation_p.I79N	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	79	Ig-like V-type.					anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		ATATCCTATAATTCGATAGTT	0.458													46	116					0	0	0	0	T	42190981	T	T	42190981	3	4	166	1	0	0	0	0	1	0	0	0	3212	101	4	5	573	5	CEACAM7	19	42190981	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	674978	42190981	16938002	965	31293											
PSG6	5675	broad.mit.edu	37	chr19	43529181	43529181	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcatgacttgggcagtggtaGgcaagttccagaagtttaaa	12	11	12	6	0	1	2	1	1	0	1	2	2	2	2	1	3	0	5	1	3	5	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:43529181G>T	uc002ovh.1	-	2	199	c.110C>A	c.(109-111)CCT>CAT	p.P37H	PSG11_uc002ouw.2_Missense_Mutation_p.P37H|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.P37H|PSG11_uc002ovm.1_Missense_Mutation_p.P31H|PSG11_uc002ovn.1_Missense_Mutation_p.P37H|PSG11_uc002ovo.1_Intron|PSG11_uc002ovp.1_Intron			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	31					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GGCAGTGGTAGGCAAGTTCCA	0.483													50	153					4.01344e-20	9.36469e-20	1	0	T	43529181	T	T	43529181	3	4	166	1	0	0	0	0	1	0	0	0	12721	1000	35	4		4	PSG6	19	43529181	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1338200	43529181	15599802	966	31294											
PSG6	5675	broad.mit.edu	37	chr19	43585036	43585036	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catgtggaatcacttacggtAtaaggtgaaggtgaaatatc	14	11	11	5	1	1	2	1	2	0	0	2	3	1	3	0	4	1	1	0	4	7	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:43585036A>G	uc002ovi.2	-	2	520	c.427T>C	c.(427-429)TAC>CAC	p.Y143H	PSG6_uc010xwk.1_Intron|PSG2_uc002ovr.2_Missense_Mutation_p.Y143H|PSG2_uc002ovq.3_Missense_Mutation_p.Y143H|PSG2_uc010eiq.1_Missense_Mutation_p.Y143H|PSG2_uc002ovs.3_Missense_Mutation_p.Y143H|PSG2_uc002ovt.3_Missense_Mutation_p.Y143H			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	142	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				CACTTACGGTATAAGGTGAAG	0.507													37	131					0	0	0	0	G	43585036	G	G	43585036	3	3	166	1	0	0	0	0	1	0	0	0	12721	449	16	5		5	PSG6	19	43585036	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	55855	43585036	15543947	967	31295											
XRCC1	7515	broad.mit.edu	37	chr19	44051050	44051050	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaccttctgaggaagctTgggggcttcatctccgctgc	6	11	12	12	1	4	2	2	1	2	1	5	3	4	3	2	3	2	3	2	3	1	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:44051050T>A	uc002owt.2	-	11	1399	c.1279A>T	c.(1279-1281)AAG>TAG	p.K427*	XRCC1_uc010xwp.1_Nonsense_Mutation_p.K396*	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	427					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				TGAGGAAGCTTGGGGGCTTCA	0.617								Other_BER_factors					18	64					0	0	0	0	A	44051050	A	A	44051050	4	1	166	1	0	0	0	0	0	1	0	0	17520	1821	63	5	650	5	XRCC1	19	44051050	Nonsense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	466014	44051050	15077933	968	31296											
CADM4	199731	broad.mit.edu	37	chr19	44131332	44131332	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttacctagtaccgtgagcGtggcaatctggtggtgggtg	6	11	16	8	3	1	1	0	1	1	0	1	1	1	1	2	4	3	3	2	4	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:44131332G>T	uc002oxc.1	-	3	399	c.350C>A	c.(349-351)ACG>AAG	p.T117K		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	117	Ig-like V-type.|Extracellular (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				TACCGTGAGCGTGGCAATCTG	0.498													26	71					2.46105e-21	5.81865e-21	1	0	T	44131332	T	T	44131332	3	4	166	1	0	0	0	0	1	0	0	0	2581	1145	40	3	844	3	CADM4	19	44131332	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	80282	44131332	14997651	969	31297											
OPA3	80207	broad.mit.edu	37	chr19	46056875	46056875	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagttcctccagggcgcccTgtggcggcgccgcctgcacc	3	6	14	18	4	0	0	0	0	0	0	2	0	2	0	6	3	1	3	6	3	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:46056875T>A	uc002pck.3	-	2	537	c.437A>T	c.(436-438)CAG>CTG	p.Q146L	OPA3_uc002pcj.3_Intron|OPA3_uc010xxk.1_Missense_Mutation_p.Q93L	NM_025136	NP_079412	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform b	146	Potential.				response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		CAGGGCGCCCTGTGGCGGCGC	0.716													13	39					0	0	0	0	A	46056875	A	A	46056875	3	1	166	1	0	0	0	0	1	0	0	0	10926	1580	55	5	511	5	OPA3	19	46056875	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1925543	46056875	13072108	970	31298											
DMWD	1762	broad.mit.edu	37	chr19	46290016	46290016	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggggcggggccgaggcgcaGgggtggctgacgttgtacag	5	6	22	8	4	0	1	0	1	0	0	0	2	0	1	1	8	1	4	1	8	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:46290016G>A	uc002pdj.1	-	3	784	c.738C>T	c.(736-738)CCC>CCT	p.P246P	DMWD_uc002pdk.1_Silent_p.P246P|DMWD_uc010eko.1_5'UTR	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	246	WD 1.				meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CCGAGGCGCAGGGGTGGCTGA	0.627													22	43					0	0	0	0	A	46290016	A	A	46290016	2	1	166	1	0	0	0	0	0	0	0	1	4615	987	35	4		4	DMWD	19	46290016	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	233141	46290016	12838967	971	31299											
KPTN	11133	broad.mit.edu	37	chr19	47978726	47978726	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgccccgtcctccaacccctGtagccgacgtctcctctgct	4	10	7	20	3	2	0	0	0	2	0	5	1	4	0	8	0	4	2	8	0	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:47978726G>T	uc002pgy.2	-	12	1362	c.1258C>A	c.(1258-1260)CAG>AAG	p.Q420K	KPTN_uc010xys.1_RNA	NM_007059	NP_008990	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	420					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			ovary(1)	1		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		TCCAACCCCTGTAGCCGACGT	0.612													10	20					3.86212e-05	6.52565e-05	1	0	T	47978726	T	T	47978726	3	4	166	1	0	0	0	0	1	0	0	0	8476	1386	48	4	56	4	KPTN	19	47978726	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1688710	47978726	11150257	972	31300											
CRX	1406	broad.mit.edu	37	chr19	48339545	48339545	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcaccaccttcacccggaGccaactggaggagctggagg	9	4	14	14	2	1	0	1	0	0	0	1	4	1	4	4	5	3	2	4	5	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:48339545G>A	uc002phq.3	+	3	350	c.146G>A	c.(145-147)AGC>AAC	p.S49N	CRX_uc010elm.1_RNA	NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	49	Homeobox.				organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		TTCACCCGGAGCCAACTGGAG	0.632													22	58					0	0	0	0	A	48339545	A	A	48339545	3	1	166	1	0	0	0	0	1	0	0	0	3917	971	34	4	152	4	CRX	19	48339545	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	360819	48339545	10789438	973	31301											
PNKP	11284	broad.mit.edu	37	chr19	50364538	50364538	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactggcagtacagccgcccCagcctcggctccacccatag	9	5	9	18	2	0	0	0	0	0	0	2	0	1	0	6	2	4	3	6	2	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:50364538C>A	uc002pqh.2	-	16	1585	c.1533G>T	c.(1531-1533)CTG>CTT	p.L511L	PNKP_uc002pqg.2_Silent_p.L292L|PNKP_uc002pqi.2_Silent_p.L472L|PNKP_uc002pqj.2_Silent_p.L511L|PNKP_uc010enm.2_Silent_p.L480L|PNKP_uc002pqk.2_3'UTR	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	511					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		ACAGCCGCCCCAGCCTCGGCT	0.622								Other_BER_factors					45	80					1.8453e-21	4.37338e-21	1	0	A	50364538	A	A	50364538	2	1	166	1	0	0	0	0	0	0	0	1	12202	581	21	4		4	PNKP	19	50364538	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2024993	50364538	8764445	974	31302											
C19orf41	126123	broad.mit.edu	37	chr19	50657863	50657863	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggatgactcacgagaccAcgatgaccacgaagacaaag	17	3	10	11	3	1	4	1	2	0	2	1	8	1	5	2	1	0	0	2	1	3	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:50657863A>G	uc002prp.1	-	6	704	c.617T>C	c.(616-618)GTG>GCG	p.V206A		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	206	Helical; (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		TCACGAGACCACGATGACCAC	0.577													20	36					0	0	0	0	G	50657863	G	G	50657863	3	3	166	1	0	0	0	0	1	0	0	0	1933	159	6	5	56	5	C19orf41	19	50657863	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	293325	50657863	8471120	975	31303											
SYT3	84258	broad.mit.edu	37	chr19	51133373	51133373	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggccgctcctcactgctggGgtccggctgggaggtcagag	4	8	17	12	2	2	1	2	0	0	1	4	2	4	2	3	6	1	3	3	6	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:51133373G>T	uc002pst.2	-	3	1364	c.730C>A	c.(730-732)CCC>ACC	p.P244T	SYT3_uc002psv.2_Missense_Mutation_p.P244T|SYT3_uc010ycd.1_Missense_Mutation_p.P244T	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	244	Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		TCACTGCTGGGGTCCGGCTGG	0.642													9	25					2.17888e-05	3.72003e-05	1	0	T	51133373	T	T	51133373	3	4	166	1	0	0	0	0	1	0	0	0	15541	1232	43	4	1066	4	SYT3	19	51133373	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	475510	51133373	7995610	976	31304											
GPR32	2854	broad.mit.edu	37	chr19	51274592	51274592	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atccgggccaagctcttgcgGgagggctgggtccatgccaa	7	7	15	12	2	1	0	0	0	1	0	3	1	3	1	4	4	3	2	4	4	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:51274592G>T	uc010ycf.1	+	1	735	c.735G>T	c.(733-735)CGG>CGT	p.R245R		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	245	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		AGCTCTTGCGGGAGGGCTGGG	0.602													20	49					4.63292e-17	1.03305e-16	1	0	T	51274592	T	T	51274592	2	4	166	1	0	0	0	0	0	0	0	1	6726	1219	43	4		4	GPR32	19	51274592	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	141219	51274592	7854391	977	31305											
CEACAM18	729767	broad.mit.edu	37	chr19	51984682	51984682	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcatctccgtcaatgccAgctccctggtggagaacatg	8	9	12	12	1	2	1	1	0	1	1	4	2	3	1	3	3	3	2	3	3	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:51984682A>G	uc002pwv.1	+	4	619	c.619A>G	c.(619-621)AGC>GGC	p.S207G		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	207						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CGTCAATGCCAGCTCCCTGGT	0.502													13	35					0	0	0	0	G	51984682	G	G	51984682	3	3	166	1	0	0	0	0	1	0	0	0	3204	188	7	5	633	5	CEACAM18	19	51984682	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	710090	51984682	7144301	978	31306											
PRKCG	5582	broad.mit.edu	37	chr19	54401341	54401341	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttcagcttcctcatggtTctaggaaaaggcagttttgg	9	13	11	8	0	3	0	2	0	1	0	4	2	4	1	1	4	1	4	1	4	3	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54401341T>C	uc002qcq.1	+	10	1350	c.1068T>C	c.(1066-1068)GTT>GTC	p.V356V	PRKCG_uc010yef.1_Missense_Mutation_p.F327S|PRKCG_uc010yeg.1_Silent_p.V356V|PRKCG_uc010yeh.1_Silent_p.V243V	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	356	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TCCTCATGGTTCTAGGAAAAG	0.502													19	42					0	0	0	0	C	54401341	C	C	54401341	2	2	166	1	0	0	0	0	0	0	0	1	12574	1770	62	5		5	PRKCG	19	54401341	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2416659	54401341	4727642	979	31307											
PRKCG	5582	broad.mit.edu	37	chr19	54403889	54403889	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgaagctggacaatgtgatGctggatgctgagggacacat	11	9	14	7	0	0	3	0	3	0	0	0	6	0	6	0	3	3	3	0	3	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54403889G>A	uc002qcq.1	+	14	1743	c.1461G>A	c.(1459-1461)ATG>ATA	p.M487I	PRKCG_uc010yeg.1_Missense_Mutation_p.M487I|PRKCG_uc010yeh.1_Missense_Mutation_p.M374I	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	487	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACAATGTGATGCTGGATGCTG	0.542													70	129					0	0	0	0	A	54403889	A	A	54403889	3	1	166	1	0	0	0	0	1	0	0	0	12574	1319	46	4	1515	4	PRKCG	19	54403889	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2548	54403889	4725094	980	31308											
LILRA6	79168	broad.mit.edu	37	chr19	54742904	54742904	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaatcccgaggaacaccagGaccaagcctgccatgcccat	13	4	9	15	1	0	1	0	0	0	1	1	4	1	3	6	2	4	0	6	2	3	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54742904G>T	uc002qeu.1	-	8	1495	c.1371C>A	c.(1369-1371)GTC>GTA	p.V457V	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Silent_p.V301V	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	457	Helical; (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGAACACCAGGACCAAGCCTG	0.577													19	55					1.33834e-09	2.56667e-09	1	0	T	54742904	T	T	54742904	2	4	166	1	0	0	0	0	0	0	0	1	8830	1161	41	2		2	LILRA6	19	54742904	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	339015	54742904	4386079	981	31309											
LILRA4	23547	broad.mit.edu	37	chr19	54848235	54848235	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggactcatggggaattcagCctggtacttatgagctccgt	9	11	12	9	1	2	1	2	1	0	0	3	3	3	3	2	4	3	2	2	4	3	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54848235C>A	uc002qfj.2	-	6	1189	c.1132G>T	c.(1132-1134)GCT>TCT	p.A378S	LILRA4_uc002qfi.2_Missense_Mutation_p.A312S	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	378	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GGGAATTCAGCCTGGTACTTA	0.587													51	158					1.21353e-23	2.94008e-23	1	0	A	54848235	A	A	54848235	3	1	166	1	0	0	0	0	1	0	0	0	8828	739	26	4	379	4	LILRA4	19	54848235	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	105331	54848235	4280748	982	31310											
TTYH1	57348	broad.mit.edu	37	chr19	54933436	54933436	+	Frame_Shift_Del	DEL	C	-	-																															ccctggaggaggtgctcgagCcgcgcacggagctggtggct																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54933436delC	uc002qfq.2	+	4	582	c.490delC	c.(490-492)CCGfs	p.P164fs	TTYH1_uc010yey.1_Frame_Shift_Del_p.P213fs|TTYH1_uc002qfr.2_Frame_Shift_Del_p.P164fs|TTYH1_uc002qft.2_Frame_Shift_Del_p.P164fs|TTYH1_uc002qfu.1_Frame_Shift_Del_p.P76fs	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	164	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GGTGCTCGAGCCGCGCACGGA	0.716													---	---	---								-	54933436	-	-	54933436	7	5	166	1	0	1	0	1	0	0	0	0	16807	739	26	0	504	0	TTYH1	19	54933436	Frame_Shift_Del	DEL	C	TCGA-CR-7402-01A-11D-2012-08	85201	54933436	4195547	983	31311											
LILRB1	10859	broad.mit.edu	37	chr19	55146717	55146717	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attcttcccccaggtccagcCcagctgccgatgcccaggaa	8	7	9	17	1	1	0	0	0	1	0	3	2	3	1	6	2	4	1	6	2	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:55146717C>A	uc002qgj.2	+	13	1907	c.1567C>A	c.(1567-1569)CCA>ACA	p.P523T	LILRB1_uc010erp.1_Missense_Mutation_p.P138T|LILRB1_uc002qgl.2_Missense_Mutation_p.P523T|LILRB1_uc002qgk.2_Missense_Mutation_p.P524T|LILRB1_uc002qgm.2_Missense_Mutation_p.P524T|LILRB1_uc010erq.2_Missense_Mutation_p.P507T|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	523	Cytoplasmic (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CAGGTCCAGCCCAGCTGCCGA	0.607										HNSCC(37;0.09)			15	77					0.000422831	0.000697601	1	0	A	55146717	A	A	55146717	3	1	166	1	0	0	0	0	1	0	0	0	8831	623	22	4	1612	4	LILRB1	19	55146717	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	213281	55146717	3982266	984	31312											
NCR1	9437	broad.mit.edu	37	chr19	55417664	55417664	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccgtcttccagggctgtgTctgagtcagaggatcagcgc	6	10	13	12	2	4	2	2	1	2	1	6	3	6	3	2	2	1	1	2	2	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:55417664T>A	uc002qib.2	+	2	80	c.42T>A	c.(40-42)TGT>TGA	p.C14*	NCR1_uc002qic.2_Nonsense_Mutation_p.C14*|NCR1_uc002qie.2_Nonsense_Mutation_p.C14*|NCR1_uc002qid.2_Nonsense_Mutation_p.C14*|NCR1_uc002qif.2_Nonsense_Mutation_p.C14*|NCR1_uc010esj.2_Intron	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	14					cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		CAGGGCTGTGTCTGAGTCAGA	0.612													14	56					0	0	0	0	A	55417664	A	A	55417664	4	1	166	1	0	0	0	0	0	1	0	0	10291	1673	58	5	48	5	NCR1	19	55417664	Nonsense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	270947	55417664	3711319	985	31313											
NLRP4	147945	broad.mit.edu	37	chr19	56370017	56370017	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agttttgtgaagacgacctcCggagaaatggggttgttgac	10	11	14	6	2	0	4	0	2	0	2	1	6	1	4	2	3	0	3	2	3	2	4	rs140509890		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:56370017C>A	uc002qmd.3	+	3	1680	c.1258C>A	c.(1258-1260)CGG>AGG	p.R420R	NLRP4_uc002qmf.2_Silent_p.R345R|NLRP4_uc010etf.2_Silent_p.R251R	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	420	NACHT.						ATP binding	p.R420Q(1)		ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AGACGACCTCCGGAGAAATGG	0.582													32	104					4.74835e-14	9.96443e-14	1	0	A	56370017	A	A	56370017	2	1	166	1	0	0	0	0	0	0	0	1	10533	643	23	3		3	NLRP4	19	56370017	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	952353	56370017	2758966	986	31314											
NLRP4	147945	broad.mit.edu	37	chr19	56372754	56372754	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctttcttgaccacaggtCggattacagcctcatctgtt	7	14	8	12	1	3	1	1	1	2	0	5	2	4	2	3	2	2	1	3	2	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:56372754C>A	uc002qmd.3	+	4	2281	c.1859C>A	c.(1858-1860)TCG>TAG	p.S620*	NLRP4_uc002qmf.2_Nonsense_Mutation_p.S545*|NLRP4_uc010etf.2_Nonsense_Mutation_p.S451*	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	620							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GACCACAGGTCGGATTACAGC	0.552													16	25					1.5739e-10	3.07255e-10	1	0	A	56372754	A	A	56372754	4	1	166	1	0	0	0	0	0	1	0	0	10533	893	31	3	1869	3	NLRP4	19	56372754	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2737	56372754	2756229	987	31315											
NLRP4	147945	broad.mit.edu	37	chr19	56382227	56382227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctcagcgagcagtgctgcGaatacatctctgaaatgctt	11	10	9	11	2	2	1	1	1	1	0	3	3	2	1	1	0	6	3	1	0	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:56382227G>A	uc002qmd.3	+	7	2811	c.2389G>A	c.(2389-2391)GAA>AAA	p.E797K	NLRP4_uc002qmf.2_Missense_Mutation_p.E722K|NLRP4_uc010etf.2_Missense_Mutation_p.E572K	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	797							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GCAGTGCTGCGAATACATCTC	0.512													25	51					0	0	0	0	A	56382227	A	A	56382227	3	1	166	1	0	0	0	0	1	0	0	0	10533	1059	37	1	2411	1	NLRP4	19	56382227	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	9473	56382227	2746756	988	31316											
PEG3	5178	broad.mit.edu	37	chr19	57335011	57335011	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actctcttctgttccgggtcAtgtcgtcgtcgctggtcacg	3	14	11	13	5	4	0	2	0	2	0	9	0	5	0	1	2	0	2	1	2	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:57335011A>T	uc002qnu.2	-	2	782	c.431T>A	c.(430-432)ATG>AAG	p.M144K	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Missense_Mutation_p.M18K|ZIM2_uc002qnq.2_Missense_Mutation_p.M18K|ZIM2_uc010etp.2_Missense_Mutation_p.M18K|ZIM2_uc010ygs.1_Missense_Mutation_p.M18K|PEG3_uc002qnt.2_Missense_Mutation_p.M144K|PEG3_uc002qnv.2_Missense_Mutation_p.M144K|PEG3_uc002qnw.2_Missense_Mutation_p.M18K|PEG3_uc002qnx.2_Missense_Mutation_p.M18K|PEG3_uc010etr.2_Missense_Mutation_p.M144K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	144					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTTCCGGGTCATGTCGTCGTC	0.552													29	62					0	0	0	0	T	57335011	T	T	57335011	3	4	166	1	0	0	0	0	1	0	0	0	11774	217	8	5	4365	5	PEG3	19	57335011	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	952784	57335011	1793972	989	31317											
USP29	57663	broad.mit.edu	37	chr19	57641686	57641686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgaaagcaccaaaccacCtcttcccttgagcagtagtg	13	8	7	13	0	1	2	0	2	1	0	2	2	2	2	4	0	3	3	4	0	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:57641686C>T	uc002qny.2	+	4	1999	c.1643C>T	c.(1642-1644)CCT>CTT	p.P548L		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	548					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACCAAACCACCTCTTCCCTTG	0.418													52	143					0	0	0	0	T	57641686	T	T	57641686	3	4	166	1	0	0	0	0	1	0	0	0	17127	681	24	4	1645	4	USP29	19	57641686	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	306675	57641686	1487297	990	31318											
ZNF324B	388569	broad.mit.edu	37	chr19	58967712	58967712	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtttcgccaagggcgccgtGctgctcagccaccggcgcat	5	7	14	15	5	1	0	1	0	0	0	2	0	1	0	4	3	3	4	4	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:58967712G>T	uc002qsv.1	+	4	1508	c.1401G>T	c.(1399-1401)GTG>GTT	p.V467V	ZNF324B_uc002qsu.1_Silent_p.V457V|ZNF324B_uc010euq.1_Silent_p.V467V	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	467	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGGGCGCCGTGCTGCTCAGCC	0.682													23	68					1.22574e-08	2.29241e-08	1	0	T	58967712	T	T	58967712	2	4	166	1	0	0	0	0	0	0	0	1	17912	1306	46	4		4	ZNF324B	19	58967712	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1326026	58967712	161271	991	31319											
CHGB	1114	broad.mit.edu	37	chr20	5903868	5903868	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccctgaggacctggagtggGagcgctataggggcagagga	9	5	18	9	1	0	2	0	1	0	1	0	6	0	6	3	6	1	2	3	6	2	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:5903868G>A	uc002wmg.2	+	4	1384	c.1078G>A	c.(1078-1080)GAG>AAG	p.E360K	CHGB_uc010zqz.1_Missense_Mutation_p.E43K	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	360						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						CCTGGAGTGGGAGCGCTATAG	0.527													33	94					0	0	0	0	A	5903868	A	A	5903868	3	1	166	1	0	0	0	0	1	0	0	0	3354	1175	41	2	1092	2	CHGB	20	5903868	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08		5903868	57121652	992	31320											
HAO1	54363	broad.mit.edu	37	chr20	7915261	7915261	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtttcagcaacattccggagCatccttggatacagcttcca	10	11	8	12	1	1	0	1	0	0	0	4	2	4	2	3	2	5	4	3	2	2	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:7915261C>G	uc002wmw.1	-	2	183	c.159G>C	c.(157-159)ATG>ATC	p.M53I	HAO1_uc010gbu.2_Missense_Mutation_p.M53I	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	53	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						CATTCCGGAGCATCCTTGGAT	0.403													24	54					0	0	0	0	G	7915261	G	G	7915261	3	3	166	1	0	0	0	0	1	0	0	0	6990	710	25	4	981	4	HAO1	20	7915261	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2011393	7915261	55110259	993	31321											
FLRT3	23767	broad.mit.edu	37	chr20	14306911	14306911	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaggtgacagacttcacAgtaattgtaattgtttttct	11	16	8	6	0	3	3	2	1	1	2	3	3	3	3	0	1	0	3	0	1	2	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:14306911A>C	uc002wov.1	-	3	1709	c.1242T>G	c.(1240-1242)ACT>ACG	p.T414T	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Silent_p.T414T	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	414	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		CAGACTTCACAGTAATTGTAA	0.468													46	117					0	0	0	0	C	14306911	C	C	14306911	2	2	166	1	0	0	0	0	0	0	0	1	5972	175	7	5		5	FLRT3	20	14306911	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	6391650	14306911	48718609	994	31322											
PCSK2	5126	broad.mit.edu	37	chr20	17446125	17446125	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccttgatgcaggtgccatgGtgaaaatggctaaagactgg	11	10	13	7	0	0	3	0	2	0	1	1	3	1	3	2	4	2	2	2	4	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:17446125G>A	uc002wpm.2	+	11	1677	c.1357G>A	c.(1357-1359)GTG>ATG	p.V453M	PCSK2_uc002wpl.2_Missense_Mutation_p.V434M|PCSK2_uc010zrm.1_Missense_Mutation_p.V418M|PCSK2_uc002wpn.2_Missense_Mutation_p.V107M	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	453					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGGTGCCATGGTGAAAATGGC	0.567													10	20					0	0	0	0	A	17446125	A	A	17446125	3	1	166	1	0	0	0	0	1	0	0	0	11655	1261	44	4	1399	4	PCSK2	20	17446125	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3139214	17446125	45579395	995	31323											
DTD1	92675	broad.mit.edu	37	chr20	18724787	18724787	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagaggaaagaaaagaccaGagctaagggaccttctgaat	17	5	12	7	0	1	5	0	1	1	4	1	7	1	7	2	2	1	2	2	2	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:18724787G>T	uc002wrf.3	+	5	682	c.521G>T	c.(520-522)AGA>ATA	p.R174I		NM_080820	NP_543010	Q8TEA8	DTD1_HUMAN	D-tyrosyl-tRNA deacylase 1	174					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds			ovary(2)	2						GAAAAGACCAGAGCTAAGGGA	0.443													12	17					3.07112e-06	5.37446e-06	1	0	T	18724787	T	T	18724787	3	4	166	1	0	0	0	0	1	0	0	0	4808	942	33	2	539	2	DTD1	20	18724787	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1278662	18724787	44300733	996	31324											
FOXA2	3170	broad.mit.edu	37	chr20	22563227	22563227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcaggaaacagtcgttgaagGagagcgagtggcggatggag	12	6	18	5	3	1	2	1	1	0	1	2	7	1	5	0	5	2	1	0	5	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:22563227G>A	uc002wsn.2	-	3	825	c.635C>T	c.(634-636)TCC>TTC	p.S212F	FOXA2_uc002wsm.2_Missense_Mutation_p.S218F	NM_153675	NP_710141	Q9Y261	FOXA2_HUMAN	forkhead box A2 isoform 2	212	Fork-head.				cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|kidney(1)|central_nervous_system(1)	4	Lung NSC(19;0.188)					GTCGTTGAAGGAGAGCGAGTG	0.607													15	37					0	0	0	0	A	22563227	A	A	22563227	3	1	166	1	0	0	0	0	1	0	0	0	6022	1174	41	2	742	2	FOXA2	20	22563227	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3838440	22563227	40462293	997	31325											
SSTR4	6754	broad.mit.edu	37	chr20	23017238	23017238	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcaggaagccctgcaacCagaacccggccgcaagcgca	12	1	11	17	3	0	1	0	0	0	1	0	2	0	2	5	2	6	4	5	2	4	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23017238C>A	uc002wsr.2	+	1	1182	c.1118C>A	c.(1117-1119)CCA>CAA	p.P373Q		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	373	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCCCTGCAACCAGAACCCGGC	0.667													24	59					1.04121e-07	1.90371e-07	1	0	A	23017238	A	A	23017238	3	1	166	1	0	0	0	0	1	0	0	0	15266	594	21	4	1120	4	SSTR4	20	23017238	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	454011	23017238	40008282	998	31326											
THBD	7056	broad.mit.edu	37	chr20	23029284	23029284	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcagaggtcgttgcaggaCtgcgtcgcggatgcggtgca	6	8	17	10	6	0	1	0	0	0	1	3	3	0	3	0	4	4	4	0	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23029284C>A	uc002wss.2	-	1	1018	c.858G>T	c.(856-858)CAG>CAT	p.Q286H	THBD_uc002wst.1_5'Flank|THBD_uc002wsu.1_Missense_Mutation_p.Q227H	NM_000361	NP_000352	P07204	TRBM_HUMAN	thrombomodulin precursor	286	EGF-like 2.|Extracellular (Potential).				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity				0	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	CGTTGCAGGACTGCGTCGCGG	0.716													10	15					0.000442599	0.0007296	1	0	A	23029284	A	A	23029284	3	1	166	1	0	0	0	0	1	0	0	0	15918	564	20	4	873	4	THBD	20	23029284	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	12046	23029284	39996236	999	31327											
CD93	22918	broad.mit.edu	37	chr20	23064994	23064994	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctccttcttctcctccctCttcgctctccgcttgcgata	2	17	4	18	3	5	0	0	0	5	0	10	1	6	0	4	0	1	2	4	0	1	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23064994C>G	uc002wsv.2	-	1	1984	c.1836G>C	c.(1834-1836)AAG>AAC	p.K612N		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	612	Cytoplasmic (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TCTCCTCCCTCTTCGCTCTCC	0.567													52	149					0	0	0	0	G	23064994	G	G	23064994	3	3	166	1	0	0	0	0	1	0	0	0	3062	912	32	2	130	2	CD93	20	23064994	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	35710	23064994	39960526	1000	31328											
CST8	10047	broad.mit.edu	37	chr20	23476506	23476506	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttggtaggagcacttccctgGaatggtgaattcactgtgat	9	13	12	7	0	1	2	1	2	0	0	2	4	2	4	1	4	1	2	1	4	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23476506G>C	uc002wth.1	+	4	741	c.384G>C	c.(382-384)TGG>TGC	p.W128C		NM_005492	NP_005483	O60676	CST8_HUMAN	cystatin 8 precursor	128						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					CACTTCCCTGGAATGGTGAAT	0.348													26	48					0	0	0	0	C	23476506	C	C	23476506	3	2	166	1	0	0	0	0	1	0	0	0	3995	1183	41	2	394	2	CST8	20	23476506	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	411512	23476506	39549014	1001	31329											
CST5	1473	broad.mit.edu	37	chr20	23860133	23860133	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcggctgtagtactcatcctTattaatgaccttgttgtact	8	16	8	9	1	1	1	1	1	0	0	2	1	2	1	2	1	2	5	2	1	5	7			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23860133T>A	uc002wtr.1	-	1	248	c.181A>T	c.(181-183)AAG>TAG	p.K61*		NM_001900	NP_001891	P28325	CYTD_HUMAN	cystatin D precursor	61						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding				0						TACTCATCCTTATTAATGACC	0.557													70	224					0	0	0	0	A	23860133	A	A	23860133	4	1	166	1	0	0	0	0	0	1	0	0	3992	1763	61	5	259	5	CST5	20	23860133	Nonsense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	383627	23860133	39165387	1002	31330											
ACSS1	84532	broad.mit.edu	37	chr20	24995843	24995843	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgtgaagccactcccaggCctcacagttgatgggctctc	7	9	10	15	0	2	2	1	2	1	0	4	2	3	2	4	2	1	2	4	2	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:24995843C>A	uc002wub.2	-	8	2148	c.1270G>T	c.(1270-1272)GCC>TCC	p.A424S	ACSS1_uc002wuc.2_Missense_Mutation_p.A424S|ACSS1_uc010gdc.2_Missense_Mutation_p.A219S|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Missense_Mutation_p.A341S	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	424					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CACTCCCAGGCCTCACAGTTG	0.522													20	39					7.41877e-09	1.39013e-08	1	0	A	24995843	A	A	24995843	3	1	166	1	0	0	0	0	1	0	0	0	188	739	26	4	827	4	ACSS1	20	24995843	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1135710	24995843	38029677	1003	31331											
BPIL1	80341	broad.mit.edu	37	chr20	31601615	31601615	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggactggcatccctacaGcgccccagagcccctggagc	8	5	11	17	1	1	1	1	0	0	1	2	3	2	3	5	3	4	1	5	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:31601615G>T	uc002wyj.2	+	5	503	c.309_splice	c.e5-1	p.R103_splice		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing							extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						CATCCCTACAGCGCCCCAGAG	0.637													18	58					3.32936e-07	5.99774e-07	1	0	T	31601615	T	T	31601615	5	4	166	1	0	0	0	0	0	0	1	0	1496	985	34	4	322	4	BPIL1	20	31601615	Splice_Site	SNP	G	TCGA-CR-7402-01A-11D-2012-08	6605772	31601615	31423905	1004	31332											
BPIL1	80341	broad.mit.edu	37	chr20	31601640	31601640	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagagcccctggagctgacGctgcctgtggaactgctggc	6	7	14	14	1	0	2	0	1	0	1	0	4	0	4	4	3	5	3	4	3	1	0	rs148455522	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:31601640G>C	uc002wyj.2	+	5	527	c.333G>C	c.(331-333)ACG>ACC	p.T111T		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	111						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						TGGAGCTGACGCTGCCTGTGG	0.617													10	54					0	0	0	0	C	31601640	C	C	31601640	2	2	166	1	0	0	0	0	0	0	0	1	1496	1074	38	3		3	BPIL1	20	31601640	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	25	31601640	31423880	1005	31333											
GSS	2937	broad.mit.edu	37	chr20	33519801	33519801	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgggccacagcctcaggctGgccagggagcaacatctcca	9	4	13	15	1	2	0	1	0	1	0	3	1	2	1	4	4	3	2	4	4	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:33519801G>T	uc002xbg.2	-	10	1050	c.970C>A	c.(970-972)CAG>AAG	p.Q324K	GSS_uc010zun.1_Missense_Mutation_p.Q196K|GSS_uc010zuo.1_Missense_Mutation_p.Q213K|GSS_uc010zup.1_Missense_Mutation_p.Q255K|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_Missense_Mutation_p.Q54K	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	324					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	GCCTCAGGCTGGCCAGGGAGC	0.632													51	72					1.35964e-18	3.1278e-18	1	0	T	33519801	T	T	33519801	3	4	166	1	0	0	0	0	1	0	0	0	6868	1357	47	4	470	4	GSS	20	33519801	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1918161	33519801	29505719	1006	31334											
LBP	3929	broad.mit.edu	37	chr20	36993246	36993246	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagggtgaaatctttcatcGtaaccaccgttctccagtta	10	12	7	12	2	3	1	1	1	2	0	5	1	3	1	4	1	1	3	4	1	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:36993246G>A	uc002xic.1	+	8	796	c.761G>A	c.(760-762)CGT>CAT	p.R254H		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	254					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				ATCTTTCATCGTAACCACCGT	0.488													38	61					0	0	0	0	A	36993246	A	A	36993246	3	1	166	1	0	0	0	0	1	0	0	0	8691	1145	40	1	791	1	LBP	20	36993246	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	3473445	36993246	26032274	1007	31335											
PTPRT	11122	broad.mit.edu	37	chr20	41306563	41306563	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtcccgtacccccctcacCtggtcgtgtgaggagcactc	5	8	11	17	3	1	1	1	1	0	0	4	2	2	2	5	3	2	2	5	3	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:41306563C>A	uc002xkg.2	-	7	1280	c.1096G>T	c.(1096-1098)GGT>TGT	p.G366C	PTPRT_uc010ggj.2_Missense_Mutation_p.G366C	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	366	Extracellular (Potential).|Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.G366V(1)		skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCCCCCTCACCTGGTCGTGTG	0.562													32	38					2.85442e-18	6.49786e-18	1	0	A	41306563	A	A	41306563	3	1	166	1	0	0	0	0	1	0	0	0	12877	681	24	4	3390	4	PTPRT	20	41306563	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	4313317	41306563	21718957	1008	31336											
MYBL2	4605	broad.mit.edu	37	chr20	42328423	42328423	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctgaccaactggccctcCgtccctcctaccataaagga	9	9	6	17	1	1	1	0	1	1	0	4	2	4	2	6	2	2	0	6	2	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:42328423C>T	uc002xlb.1	+	7	905	c.690C>T	c.(688-690)TCC>TCT	p.S230S	MYBL2_uc010zwj.1_Silent_p.S206S|MYBL2_uc002xla.1_Silent_p.S230S	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	230						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACTGGCCCTCCGTCCCTCCTA	0.443													16	28					0	0	0	0	T	42328423	T	T	42328423	2	4	166	1	0	0	0	0	0	0	0	1	10063	639	23	1		1	MYBL2	20	42328423	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1021860	42328423	20697097	1009	31337											
C20orf85	128602	broad.mit.edu	37	chr20	56735866	56735866	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagctgtgctggcccaagcaGggcgtgcactgaatccagac	9	6	14	12	1	0	2	0	1	0	1	1	3	1	2	2	2	4	4	2	2	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:56735866G>T	uc002xyv.2	+	4	440	c.402G>T	c.(400-402)CAG>CAT	p.Q134H		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	134										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			GGCCCAAGCAGGGCGTGCACT	0.597													11	14					3.07112e-06	5.37446e-06	1	0	T	56735866	T	T	56735866	3	4	166	1	0	0	0	0	1	0	0	0	2130	991	35	4	416	4	C20orf85	20	56735866	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	14407443	56735866	6289654	1010	31338											
NPEPL1	79716	broad.mit.edu	37	chr20	57268861	57268861	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtcccctctacctgaactaCgccaccgtggctgccctgcc	5	9	8	19	2	1	1	0	1	1	0	2	1	2	1	7	1	5	1	7	1	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:57268861C>T	uc010zzs.1	+	2	314	c.219C>T	c.(217-219)TAC>TAT	p.Y73Y	NPEPL1_uc010zzr.1_Silent_p.Y25Y|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Silent_p.Y45Y|NPEPL1_uc002xzp.2_Translation_Start_Site	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	73					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			ACCTGAACTACGCCACCGTGG	0.672													29	34					0	0	0	0	T	57268861	T	T	57268861	2	4	166	1	0	0	0	0	0	0	0	1	10628	547	19	1		1	NPEPL1	20	57268861	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	532995	57268861	5756659	1011	31339											
PHACTR3	116154	broad.mit.edu	37	chr20	58330273	58330273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgcaaccccgatggaggacCccgatctgtacagagtgaac	11	7	11	12	2	1	2	0	1	1	1	1	6	1	4	4	2	4	2	4	2	3	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:58330273C>T	uc002yau.2	+	4	862	c.395C>T	c.(394-396)CCC>CTC	p.P132L	PHACTR3_uc002yat.2_Missense_Mutation_p.P129L|PHACTR3_uc010zzw.1_Missense_Mutation_p.P91L|PHACTR3_uc002yav.2_Missense_Mutation_p.P91L|PHACTR3_uc002yaw.2_Missense_Mutation_p.P91L|PHACTR3_uc002yax.2_Missense_Mutation_p.P91L	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	132						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GATGGAGGACCCCGATCTGTA	0.587													9	17					0	0	0	0	T	58330273	T	T	58330273	3	4	166	1	0	0	0	0	1	0	0	0	11866	623	22	4	409	4	PHACTR3	20	58330273	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1061412	58330273	4695247	1012	31340											
DIDO1	11083	broad.mit.edu	37	chr20	61525097	61525097	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agctagtatggacttgggcaCcatcacagaagtcaagacag	14	7	11	9	0	2	2	2	0	0	2	2	3	2	3	1	2	1	3	1	2	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:61525097C>A	uc002ydr.1	-	12	3286	c.3022G>T	c.(3022-3024)GTG>TTG	p.V1008L	DIDO1_uc002yds.1_Missense_Mutation_p.V1008L|DIDO1_uc002ydt.1_Missense_Mutation_p.V1008L|DIDO1_uc002ydu.1_Missense_Mutation_p.V1008L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1008					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GACTTGGGCACCATCACAGAA	0.557													39	53					2.05212e-20	4.81695e-20	1	0	A	61525097	A	A	61525097	3	1	166	1	0	0	0	0	1	0	0	0	4544	507	18	4	3749	4	DIDO1	20	61525097	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3194824	61525097	1500423	1013	31341											
MYT1	4661	broad.mit.edu	37	chr20	62830234	62830234	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgagcttagaaaatgaagAcaagcgagctcgcacccgat	15	6	11	9	3	0	4	0	2	0	2	1	7	0	4	1	0	3	3	1	0	5	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:62830234A>T	uc002yii.2	+	3	384	c.20A>T	c.(19-21)GAC>GTC	p.D7V	MYT1_uc002yih.2_Missense_Mutation_p.D7V	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	7					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GAAAATGAAGACAAGCGAGCT	0.557													11	29					0	0	0	0	T	62830234	T	T	62830234	3	4	166	1	0	0	0	0	1	0	0	0	10159	275	10	5	22	5	MYT1	20	62830234	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1305137	62830234	195286	1014	31342											
HSPA13	6782	broad.mit.edu	37	chr21	15746151	15746151	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcccccaactaaaaccacCtcatcaatctcagtcttttc	12	10	3	16	0	4	0	3	0	2	0	6	1	4	0	4	0	3	0	4	0	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:15746151C>A	uc002yjt.2	-	5	1272	c.1203G>T	c.(1201-1203)GAG>GAT	p.E401D	HSPA13_uc011abx.1_Missense_Mutation_p.E193D	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	401						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						CTAAAACCACCTCATCAATCT	0.438													55	85					2.31418e-15	5.01747e-15	1	0	A	15746151	A	A	15746151	3	1	166	1	0	0	0	0	1	0	0	0	7445	680	24	4	216	4	HSPA13	21	15746151	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08		15746151	32383744	1015	31343											
SAMSN1	64092	broad.mit.edu	37	chr21	15872886	15872886	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaggaactcctgcagagtCttggattttttgctgttact	7	17	9	8	0	2	1	0	0	2	1	3	3	3	3	1	2	4	3	1	2	3	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:15872886C>A	uc002yju.1	-	6	814	c.732G>T	c.(730-732)AAG>AAT	p.K244N	SAMSN1_uc010gky.1_Missense_Mutation_p.K76N|SAMSN1_uc002yjv.1_Missense_Mutation_p.K312N	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	244	SAM.				negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CCTGCAGAGTCTTGGATTTTT	0.433													10	57					2.80697e-09	5.31049e-09	1	0	A	15872886	A	A	15872886	3	1	166	1	0	0	0	0	1	0	0	0	13895	912	32	2	401	2	SAMSN1	21	15872886	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	126735	15872886	32257009	1016	31344											
ADAMTS5	11096	broad.mit.edu	37	chr21	28338577	28338577	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacctcctccccctgccgcCggcggggctgggcggctgct	1	6	15	19	4	0	0	0	0	0	0	2	0	2	0	6	5	2	4	6	5	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:28338577C>T	uc002ymg.2	-	1	863	c.134G>A	c.(133-135)CGG>CAG	p.R45Q		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	45					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CCCCTGCCGCCGGCGGGGCTG	0.766													7	13					0	0	0	0	T	28338577	T	T	28338577	3	4	166	1	0	0	0	0	1	0	0	0	269	652	23	1	2690	1	ADAMTS5	21	28338577	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	12465691	28338577	19791318	1017	31345											
KRTAP13-3	337960	broad.mit.edu	37	chr21	31797760	31797760	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgataacaagatgaatggaaCcaccttctaggtggaaaata	17	9	9	6	0	1	3	0	2	1	1	1	5	1	5	2	3	2	0	2	3	8	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:31797760C>T	uc002yob.1	-	1	471	c.471G>A	c.(469-471)TGG>TGA	p.W157*		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	157						intermediate filament				ovary(1)|lung(1)	2						ATGAATGGAACCACCTTCTAG	0.388													19	28					0	0	0	0	T	31797760	T	T	31797760	4	4	166	1	0	0	0	0	0	1	0	0	8563	508	18	4	51	4	KRTAP13-3	21	31797760	Nonsense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3459183	31797760	16332135	1018	31346											
SFRS15	57466	broad.mit.edu	37	chr21	33064243	33064243	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaacccctgggaggaatcaTctgctccaaaacattttaat	14	10	6	11	0	2	0	1	0	1	0	3	2	3	2	3	2	3	1	3	2	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:33064243T>C	uc002ypd.2	-	14	2041	c.1615A>G	c.(1615-1617)ATG>GTG	p.M539V	SFRS15_uc002ype.2_Missense_Mutation_p.M539V|SFRS15_uc010glu.2_Missense_Mutation_p.M524V|SFRS15_uc002ypf.1_Missense_Mutation_p.M213V	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	539	RRM.					nucleus	nucleotide binding|RNA binding				0						GGAGGAATCATCTGCTCCAAA	0.408													17	52					0	0	0	0	C	33064243	C	C	33064243	3	2	166	1	0	0	0	0	1	0	0	0	14236	1449	50	5	1856	5	SFRS15	21	33064243	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	1266483	33064243	15065652	1019	31347											
AIRE	326	broad.mit.edu	37	chr21	45708269	45708269	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtccagagagctgtggccAtgtcctccggggacgtcccg	6	7	14	14	3	0	1	0	0	0	1	4	3	4	2	5	3	1	1	5	3	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:45708269A>T	uc002zei.2	+	5	707	c.580A>T	c.(580-582)ATG>TTG	p.M194L	AIRE_uc010gpq.2_5'Flank|AIRE_uc002zej.2_5'Flank|AIRE_uc010gpr.2_5'Flank	NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	194	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		AGCTGTGGCCATGTCCTCCGG	0.622									Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				37	71					0	0	0	0	T	45708269	T	T	45708269	3	4	166	1	0	0	0	0	1	0	0	0	437	217	8	5	598	5	AIRE	21	45708269	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	12644026	45708269	2421626	1020	31348											
COL6A1	1291	broad.mit.edu	37	chr21	47421935	47421935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccacagccagatgcaggagCacgtgagcctgcgcagcccc	9	3	13	16	2	0	2	0	1	0	1	0	3	0	3	5	1	6	3	5	1	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:47421935C>T	uc002zhu.1	+	31	2119	c.2017C>T	c.(2017-2019)CAC>TAC	p.H673Y	COL6A1_uc010gqd.1_Missense_Mutation_p.H4Y|COL6A1_uc002zhv.1_Missense_Mutation_p.H4Y|COL6A1_uc002zhw.1_5'Flank	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	673	VWFA 2.|C-terminal globular domain.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GATGCAGGAGCACGTGAGCCT	0.697													14	38					0	0	0	0	T	47421935	T	T	47421935	3	4	166	1	0	0	0	0	1	0	0	0	3714	710	25	4	2139	4	COL6A1	21	47421935	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1713666	47421935	707960	1021	31349											
PCNT	5116	broad.mit.edu	37	chr21	47851899	47851899	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagagagaaggaggtaagtGccacactgaagtcgacggtg	13	5	17	6	2	0	3	0	1	0	2	1	7	0	4	1	4	1	1	1	4	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:47851899G>T	uc002zji.3	+	38	8628	c.8521G>T	c.(8521-8523)GCC>TCC	p.A2841S	PCNT_uc002zjj.2_Intron	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2841	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GGAGGTAAGTGCCACACTGAA	0.567													17	39					1.78486e-19	4.14986e-19	1	0	T	47851899	T	T	47851899	3	4	166	1	0	0	0	0	1	0	0	0	11644	1319	46	4	8671	4	PCNT	21	47851899	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	429964	47851899	277996	1022	31350											
POTEH	23784	broad.mit.edu	37	chr22	16279270	16279270	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacttgctgtttttgctcaTgtacaccaagtaacagtggt	9	14	8	10	0	1	0	1	0	0	0	1	0	1	0	2	1	4	5	2	1	3	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:16279270T>C	uc010gqp.2	-	4	1005	c.953A>G	c.(952-954)CAT>CGT	p.H318R	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.H37R|POTEH_uc002zlj.1_Missense_Mutation_p.H153R	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	318	ANK 5.									skin(1)	1						TTTTTGCTCATGTACACCAAG	0.328													28	418					0	0	0	0	C	16279270	C	C	16279270	3	2	166	1	0	0	0	0	1	0	0	0	12322	1464	51	5	712	5	POTEH	22	16279270	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08		16279270	35025296	1023	31351											
CCT8L2	150160	broad.mit.edu	37	chr22	17072618	17072618	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttgcttttctagtaattgatCgcttcctttactaaattgag	9	19	6	7	1	1	2	0	2	1	0	3	2	2	2	1	0	2	3	1	0	5	11			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:17072618C>G	uc002zlp.1	-	1	1083	c.823G>C	c.(823-825)GAT>CAT	p.D275H		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	275					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGTAATTGATCGCTTCCTTTA	0.527													49	141					0	0	0	0	G	17072618	G	G	17072618	3	3	166	1	0	0	0	0	1	0	0	0	2976	884	31	3	854	3	CCT8L2	22	17072618	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	793348	17072618	34231948	1024	31352											
CCT8L2	150160	broad.mit.edu	37	chr22	17073049	17073049	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcgtaggcctcccggagcTgcgggcgaggcaggccagcc	5	4	18	14	4	0	0	0	0	0	0	1	2	1	1	4	6	3	3	4	6	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:17073049T>A	uc002zlp.1	-	1	652	c.392A>T	c.(391-393)CAG>CTG	p.Q131L		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	131					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTCCCGGAGCTGCGGGCGAGG	0.652													15	41					0	0	0	0	A	17073049	A	A	17073049	3	1	166	1	0	0	0	0	1	0	0	0	2976	1580	55	5	1285	5	CCT8L2	22	17073049	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	431	17073049	34231517	1025	31353											
TOP3B	8940	broad.mit.edu	37	chr22	22322027	22322027	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacatctgtgcgatctccCggtcaaacactcttactcgg	11	10	7	13	3	4	0	1	0	3	0	6	1	4	0	1	2	4	0	1	2	4	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:22322027C>G	uc002zvs.2	-	8	1235	c.800G>C	c.(799-801)CGG>CCG	p.R267P	TOP3B_uc010gtm.1_5'UTR|TOP3B_uc002zvr.2_5'UTR|TOP3B_uc010gtl.2_Missense_Mutation_p.R267P|TOP3B_uc002zvt.3_Missense_Mutation_p.R267P	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	267					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TGCGATCTCCCGGTCAAACAC	0.483													33	65					0	0	0	0	G	22322027	G	G	22322027	3	3	166	1	0	0	0	0	1	0	0	0	16435	652	23	3	1832	3	TOP3B	22	22322027	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	5248978	22322027	28982539	1026	31354											
CABIN1	23523	broad.mit.edu	37	chr22	24480531	24480531	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccttctgtctttttttcaaGgtggatcttatatgggagga	7	17	11	6	0	4	0	1	0	3	0	4	3	4	3	1	4	0	0	1	4	3	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:24480531G>T	uc002zzi.1	+	21	3038	c.2911_splice	c.e21-1	p.V971_splice	CABIN1_uc002zzj.1_Splice_Site_p.V921_splice|CABIN1_uc002zzl.1_Splice_Site_p.V971_splice	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1						cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TTTTTTTCAAGGTGGATCTTA	0.408													31	96					2.08457e-15	4.52464e-15	1	0	T	24480531	T	T	24480531	5	4	166	1	0	0	0	0	0	0	1	0	2540	1014	35	4	2988	4	CABIN1	22	24480531	Splice_Site	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2158504	24480531	26824035	1027	31355											
EWSR1	2130	broad.mit.edu	37	chr22	29684679	29684679	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggaccaggagagaaccggaGcatgagtggccctgataacc	12	4	14	11	2	0	3	0	2	0	1	0	7	0	6	4	4	3	1	4	4	2	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:29684679G>C	uc003aet.2	+	8	1206	c.878G>C	c.(877-879)AGC>ACC	p.S293T	EWSR1_uc003aes.3_Missense_Mutation_p.S293T|EWSR1_uc003aev.2_Missense_Mutation_p.S299T|EWSR1_uc003aew.2_Missense_Mutation_p.S237T|EWSR1_uc003aex.2_Missense_Mutation_p.S293T|EWSR1_uc003aey.2_Missense_Mutation_p.S88T|EWSR1_uc003aez.2_5'Flank	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						GAGAACCGGAGCATGAGTGGC	0.592			T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								18	25					0	0	0	0	C	29684679	C	C	29684679	3	2	166	1	0	0	0	0	1	0	0	0	5320	971	34	4	930	4	EWSR1	22	29684679	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5204148	29684679	21619887	1028	31356											
SFI1	9814	broad.mit.edu	37	chr22	31946321	31946321	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaggaacaagtacattagAgccgaggttcatggtgagaa	15	8	13	5	1	1	3	1	2	0	2	1	6	1	4	1	3	3	2	1	3	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:31946321A>T	uc003ale.2	+	6	924	c.531A>T	c.(529-531)AGA>AGT	p.R177S	SFI1_uc003ald.1_Missense_Mutation_p.R153S|SFI1_uc003alf.2_Missense_Mutation_p.R177S|SFI1_uc003alg.2_Missense_Mutation_p.R95S|SFI1_uc011alp.1_Missense_Mutation_p.R95S|SFI1_uc011alq.1_Missense_Mutation_p.R153S|SFI1_uc003alh.2_Intron	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	177	HAT 2.				G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						AGTACATTAGAGCCGAGGTTC	0.448													18	32					0	0	0	0	T	31946321	T	T	31946321	3	4	166	1	0	0	0	0	1	0	0	0	14221	301	11	5	549	5	SFI1	22	31946321	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	2261642	31946321	19358245	1029	31357											
C22orf30	253143	broad.mit.edu	37	chr22	32072838	32072838	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaggactagcagcctccTccaatatggatagcttctcg	11	9	9	12	1	1	0	0	0	1	0	4	2	3	2	3	2	3	3	3	2	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:32072838T>A	uc003alo.1	-	6	5799	c.5743A>T	c.(5743-5745)AGG>TGG	p.R1915W		NM_173566	NP_775837	Q5THK1	PR14L_HUMAN	hypothetical protein LOC253143	Error:Variant_position_missing_in_Q5THK1_after_alignment											0						AGCAGCCTCCTCCAATATGGA	0.577													5	14					0	0	0	0	A	32072838	A	A	32072838	3	1	166	1	0	0	0	0	1	0	0	0	2152	1566	54	5		5	C22orf30	22	32072838	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	126517	32072838	19231728	1030	31358											
C22orf42	150297	broad.mit.edu	37	chr22	32555017	32555017	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcttcgggaggctgaggtaCtgcatgagttgggccttctt	5	13	15	8	1	2	2	0	2	2	0	3	3	2	3	1	4	2	4	1	4	1	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:32555017C>G	uc003amd.2	-	1	227	c.186G>C	c.(184-186)CAG>CAC	p.Q62H		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	62										ovary(1)|skin(1)	2						GGCTGAGGTACTGCATGAGTT	0.537													61	174					0	0	0	0	G	32555017	G	G	32555017	3	3	166	1	0	0	0	0	1	0	0	0	2159	564	20	4	605	4	C22orf42	22	32555017	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	482179	32555017	18749549	1031	31359											
SSTR3	6753	broad.mit.edu	37	chr22	37603377	37603377	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgcgggccaccggagctgTgcgccagcgggccgagcggg	4	3	20	14	7	0	0	0	0	0	0	0	2	0	1	4	4	5	1	4	4	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:37603377T>A	uc003ara.2	-	2	528	c.466A>T	c.(466-468)ACA>TCA	p.T156S	SSTR3_uc003arb.2_Missense_Mutation_p.T156S	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	156	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						ACCGGAGCTGTGCGCCAGCGG	0.677													30	53					0	0	0	0	A	37603377	A	A	37603377	3	1	166	1	0	0	0	0	1	0	0	0	15265	1696	59	5	794	5	SSTR3	22	37603377	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	5048360	37603377	13701189	1032	31360											
APOBEC3B	9582	broad.mit.edu	37	chr22	39380220	39380220	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaatctcctttgggacacagGggtctttcgaggccaggtac	9	10	12	10	1	2	0	0	0	2	0	4	2	2	1	2	5	1	1	2	5	2	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:39380220G>T	uc003awo.1	+	2	212	c.158G>T	c.(157-159)GGG>GTG	p.G53V	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Missense_Mutation_p.G53V|APOBEC3B_uc003awq.1_RNA|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	53					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					TGGGACACAGGGGTCTTTCGA	0.368													23	7					7.87624e-14	1.64578e-13	1	0	T	39380220	T	T	39380220	3	4	166	1	0	0	0	0	1	0	0	0	790	1232	43	4	164	4	APOBEC3B	22	39380220	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1776843	39380220	11924346	1033	31361											
CACNA1I	8911	broad.mit.edu	37	chr22	40042659	40042659	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaacgggagcaccggctgaTgctggagcagcggcagcgct	8	4	17	12	4	0	1	0	1	0	0	0	3	0	3	1	4	6	7	1	4	1	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:40042659T>C	uc003ayc.2	+	8	1235	c.1235T>C	c.(1234-1236)ATG>ACG	p.M412T	CACNA1I_uc003ayd.2_Missense_Mutation_p.M412T|CACNA1I_uc003aye.2_Missense_Mutation_p.M327T|CACNA1I_uc003ayf.2_Missense_Mutation_p.M327T	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	412	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CACCGGCTGATGCTGGAGCAG	0.607													5	7					0	0	0	0	C	40042659	C	C	40042659	3	2	166	1	0	0	0	0	1	0	0	0	2558	1464	51	5	1265	5	CACNA1I	22	40042659	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	662439	40042659	11261907	1034	31362											
FAM83F	113828	broad.mit.edu	37	chr22	40417675	40417675	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggagcaggtgctgcccccCgtggagcccatccccttggg	4	7	15	15	1	0	0	0	0	0	0	1	2	1	2	6	4	4	2	6	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:40417675C>T	uc003ayk.1	+	4	1255	c.1161C>T	c.(1159-1161)CCC>CCT	p.P387P		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	387										breast(1)	1						TGCTGCCCCCCGTGGAGCCCA	0.662													13	48					0	0	0	0	T	40417675	T	T	40417675	2	4	166	1	0	0	0	0	0	0	0	1	5670	639	23	1		1	FAM83F	22	40417675	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	375016	40417675	10886891	1035	31363											
ACO2	50	broad.mit.edu	37	chr22	41918884	41918884	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgaagatatggggcgctcaGcagctgtggccaagcaggca	11	6	15	9	1	1	2	1	1	0	1	1	2	1	2	1	4	3	5	1	4	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:41918884G>T	uc003bac.2	+	10	1211	c.1189G>T	c.(1189-1191)GCA>TCA	p.A397S	ACO2_uc003bad.2_Missense_Mutation_p.A422S	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	397					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						GGGGCGCTCAGCAGCTGTGGC	0.572													22	49					5.26018e-13	1.07507e-12	1	0	T	41918884	T	T	41918884	3	4	166	1	0	0	0	0	1	0	0	0	147	971	34	4	1227	4	ACO2	22	41918884	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1501209	41918884	9385682	1036	31364											
PRR5	55615	broad.mit.edu	37	chr22	45132772	45132772	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcacgaggcggagggcgCggcggccggcggtaccagca	7	1	21	12	7	0	0	0	0	0	0	0	3	0	2	2	8	3	3	2	8	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:45132772C>A	uc003bfb.1	+	8	1084	c.812C>A	c.(811-813)GCG>GAG	p.A271E	PRR5_uc003bew.1_Missense_Mutation_p.A262E|PRR5_uc003bex.1_Missense_Mutation_p.A176E|PRR5_uc010gzt.1_Missense_Mutation_p.A294E|PRR5_uc010gzu.1_Missense_Mutation_p.A235E|PRR5_uc003bey.1_Missense_Mutation_p.A262E|PRR5_uc003bez.1_Missense_Mutation_p.A176E|PRR5-ARHGAP8_uc003bfc.2_Intron|PRR5-ARHGAP8_uc003bfd.2_Intron|PRR5-ARHGAP8_uc011aqi.1_Intron|PRR5-ARHGAP8_uc011aqj.1_Intron|PRR5_uc003bfa.1_Missense_Mutation_p.A164E|PRR5_uc003bfe.1_RNA|PRR5-ARHGAP8_uc003bfg.1_Intron|PRR5_uc003bfh.1_Missense_Mutation_p.A170E	NM_181333	NP_851850	P85299	PRR5_HUMAN	proline rich 5 (renal) isoform 1	271					cell cycle					skin(1)	1		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		GCGGAGGGCGCGGCGGCCGGC	0.711													13	39					1.5842e-08	2.95436e-08	1	0	A	45132772	A	A	45132772	3	1	166	1	0	0	0	0	1	0	0	0	12662	768	27	3	842	3	PRR5	22	45132772	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3213888	45132772	6171794	1037	31365											
GTSE1	51512	broad.mit.edu	37	chr22	46704670	46704670	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagctctggtgcccaggccCgcctcacccgggcgccgggg	3	4	15	19	4	2	0	1	0	1	0	2	0	2	0	6	5	2	1	6	5	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:46704670C>A	uc011aqy.1	+	4	804	c.592C>A	c.(592-594)CGC>AGC	p.R198S	GTSE1_uc011aqz.1_Missense_Mutation_p.R45S	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	179					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		TGCCCAGGCCCGCCTCACCCG	0.677													45	87					6.4771e-29	1.59486e-28	1	0	A	46704670	A	A	46704670	3	1	166	1	0	0	0	0	1	0	0	0	6924	652	23	3	602	3	GTSE1	22	46704670	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	1571898	46704670	4599896	1038	31366											
CRELD2	79174	broad.mit.edu	37	chr22	50315316	50315316	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagggcgacgggtcctgcCggtgccacatggggtaccag	7	5	17	12	3	0	0	0	0	0	0	1	2	1	0	4	5	3	1	4	5	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:50315316C>A	uc003bja.2	+	5	634	c.499C>A	c.(499-501)CGG>AGG	p.R167R	CRELD2_uc003biz.3_Silent_p.R167R|CRELD2_uc010haj.2_Silent_p.R167R|CRELD2_uc010hal.2_Silent_p.R167R|CRELD2_uc010hak.2_Silent_p.R167R|CRELD2_uc010ham.2_Silent_p.R167R	NM_024324	NP_077300	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2 isoform b	167	EGF-like 1.					endoplasmic reticulum|extracellular region	calcium ion binding				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		CGGGTCCTGCCGGTGCCACAT	0.647													29	102					1.75199e-13	3.62225e-13	1	0	A	50315316	A	A	50315316	2	1	166	1	0	0	0	0	0	0	0	1	3882	643	23	3		3	CRELD2	22	50315316	Silent	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3610646	50315316	989250	1039	31367											
SHOX	6473	broad.mit.edu	37	chrX	601734	601734	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctgctccctttggacacagGcgtcatcttgggcacagcca	7	9	10	15	1	2	0	1	0	1	0	3	1	3	1	3	3	2	2	3	3	0	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:601734G>T	uc004cph.1	+	5	1236	c.545G>T	c.(544-546)GGC>GTC	p.G182V	SHOX_uc004cpi.2_Missense_Mutation_p.G182V	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	182					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTGGACACAGGCGTCATCTTG	0.602													18	49					8.28177e-16	1.81976e-15	1	0	T	601734	T	T	601734	3	4	166	1	0	0	0	0	1	0	0	0	14353	1217	42	4	559	4	SHOX	23	601734	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08		601734	154668826	1040	31368											
TLR7	51284	broad.mit.edu	37	chrX	12906382	12906382	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtggccaaactggaagacCcaagagagaaacattttaat	16	8	10	7	0	0	3	0	0	0	3	0	5	0	4	2	3	2	0	2	3	5	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:12906382C>G	uc004cvc.2	+	3	2894	c.2755C>G	c.(2755-2757)CCA>GCA	p.P919A		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	919	TIR.|Cytoplasmic (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ACTGGAAGACCCAAGAGAGAA	0.458													56	47					0	0	0	0	G	12906382	G	G	12906382	3	3	166	1	0	0	0	0	1	0	0	0	16022	623	22	4	2761	4	TLR7	23	12906382	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	12304648	12906382	142364178	1041	31369											
SMS	6611	broad.mit.edu	37	chrX	22010722	22010722	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctttgatttaggggaactGtgtcaatctgacagaagcac	11	12	10	8	0	3	3	1	2	2	1	3	4	3	4	0	2	2	1	0	2	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:22010722G>A	uc004dag.2	+	10	1054	c.953G>A	c.(952-954)TGT>TAT	p.C318Y	SMS_uc010nfs.2_RNA|SMS_uc010nft.2_Intron	NM_004595	NP_004586	P52788	SPSY_HUMAN	spermine synthase	318					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			ovary(1)	1					Spermine(DB00127)	TAGGGGAACTGTGTCAATCTG	0.453													4	7					0	0	0	0	A	22010722	A	A	22010722	3	1	166	1	0	0	0	0	1	0	0	0	14877	1377	48	4	991	4	SMS	23	22010722	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	9104340	22010722	133259838	1042	31370											
DCAF8L2	347442	broad.mit.edu	37	chrX	27766738	27766738	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaccatggcagcctgtttGaccagtacatgctttggttc	7	13	10	11	0	0	1	0	1	0	0	1	1	0	1	3	2	4	6	3	2	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:27766738G>T	uc011mjy.1	+	1	1813	c.1726G>T	c.(1726-1728)GAC>TAC	p.D576Y		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						CAGCCTGTTTGACCAGTACAT	0.498													11	9					1.58986e-06	2.79725e-06	1	0	T	27766738	T	T	27766738	3	4	166	1	0	0	0	0	1	0	0	0	4295	1290	45	2	1728	2	DCAF8L2	23	27766738	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	5756016	27766738	127503822	1043	31371											
MAGEB10	139422	broad.mit.edu	37	chrX	27839501	27839501	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagggctggaagatttgatAgatgctctggacattttaga	11	12	14	4	0	1	4	0	1	1	3	1	7	1	7	0	4	1	2	0	4	3	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:27839501A>T	uc004dbw.2	+	3	305	c.78A>T	c.(76-78)ATA>ATT	p.I26I		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	26										lung(1)|breast(1)|central_nervous_system(1)	3						AAGATTTGATAGATGCTCTGG	0.512													18	20					0	0	0	0	T	27839501	T	T	27839501	2	4	166	1	0	0	0	0	0	0	0	1	9226	410	15	5		5	MAGEB10	23	27839501	Silent	SNP	A	TCGA-CR-7402-01A-11D-2012-08	72763	27839501	127431059	1044	31372											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29973704	29973704	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acacgtaccattcacaaatgCgtcagaaacactactaccga	16	7	5	13	3	2	1	2	0	0	1	2	2	2	1	2	0	5	1	2	0	5	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:29973704C>G	uc004dby.2	+	11	2366	c.1858C>G	c.(1858-1860)CGT>GGT	p.R620G		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	620	Cytoplasmic (Potential).|Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TTCACAAATGCGTCAGAAACA	0.532													7	10					0	0	0	0	G	29973704	G	G	29973704	3	3	166	1	0	0	0	0	1	0	0	0	7700	768	27	3	1896	3	IL1RAPL1	23	29973704	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	2134203	29973704	125296856	1045	31373											
NR0B1	190	broad.mit.edu	37	chrX	30326348	30326348	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cggtccccttgaggtaggcgTactccttggtactgatgttc	5	13	12	11	2	0	2	0	2	0	0	3	2	2	2	3	4	2	4	3	4	3	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:30326348T>G	uc004dcf.3	-	1	1148	c.1133A>C	c.(1132-1134)TAC>TCC	p.Y378S		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	378	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	GAGGTAGGCGTACTCCTTGGT	0.587											OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	22					0	0	0	0	G	30326348	G	G	30326348	3	3	166	1	0	0	0	0	1	0	0	0	10667	1638	57	5	287	5	NR0B1	23	30326348	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	352644	30326348	124944212	1046	31374											
DMD	1756	broad.mit.edu	37	chrX	31198490	31198490	+	Frame_Shift_Del	DEL	A	-	-																															gctggcgtcaaacttaccggAgtgcaatattccaccatggg																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:31198490delA	uc004dda.1	-	69	10327	c.10083delT	c.(10081-10083)ACTfs	p.T3361fs	DMD_uc004dcq.1_Frame_Shift_Del_p.T632fs|DMD_uc004dcr.1_Frame_Shift_Del_p.T901fs|DMD_uc004dcs.1_Frame_Shift_Del_p.T901fs|DMD_uc004dct.1_Frame_Shift_Del_p.T901fs|DMD_uc004dcu.1_Frame_Shift_Del_p.T901fs|DMD_uc004dcv.1_Frame_Shift_Del_p.T901fs|DMD_uc004dcw.2_Frame_Shift_Del_p.T2017fs|DMD_uc004dcx.2_Frame_Shift_Del_p.T2020fs|DMD_uc004dcz.2_Frame_Shift_Del_p.T3238fs|DMD_uc004dcy.1_Frame_Shift_Del_p.T3357fs|DMD_uc004ddb.1_Frame_Shift_Del_p.T3353fs|DMD_uc004dcm.1_Frame_Shift_Del_p.T293fs|DMD_uc004dcn.1_Frame_Shift_Del_p.T293fs|DMD_uc004dco.1_Frame_Shift_Del_p.T293fs|DMD_uc004dcp.1_Frame_Shift_Del_p.T293fs|DMD_uc011mkb.1_Frame_Shift_Del_p.T293fs|DMD_uc010ngm.2_Frame_Shift_Del_p.T293fs	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3361	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AACTTACCGGAGTGCAATATT	0.408													---	---	---								-	31198490	-	-	31198490	7	5	166	1	0	1	0	1	0	0	0	0	4602	291	11	0	1108	0	DMD	23	31198490	Frame_Shift_Del	DEL	A	TCGA-CR-7402-01A-11D-2012-08	872142	31198490	124072070	1047	31375											
PPP1R3F	89801	broad.mit.edu	37	chrX	49142667	49142667	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacgggctgctgtggctgcGggtggggcagggggtggtgg	2	8	24	7	2	0	0	0	0	0	0	0	0	0	0	0	9	3	4	0	9	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:49142667G>A	uc004dnh.1	+	4	1531	c.1515G>A	c.(1513-1515)GCG>GCA	p.A505A	PPP1R3F_uc011mnd.1_Silent_p.A176A|PPP1R3F_uc004dni.2_Silent_p.A159A|PPP1R3F_uc004dnj.1_Silent_p.A159A	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	505	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					CTGTGGCTGCGGGTGGGGCAG	0.657													8	2					0	0	0	0	A	49142667	A	A	49142667	2	1	166	1	0	0	0	0	0	0	0	1	12435	1103	39	1		1	PPP1R3F	23	49142667	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	17944177	49142667	106127893	1048	31376											
CCNB3	85417	broad.mit.edu	37	chrX	50052855	50052855	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attggtgaagataagaattcTttctttatggagccaatgtc	12	15	9	5	0	2	3	0	1	2	2	3	4	2	4	1	2	1	0	1	2	5	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:50052855T>A	uc004dox.3	+	6	1984	c.1686T>A	c.(1684-1686)TCT>TCA	p.S562S	CCNB3_uc004doy.2_Silent_p.S562S|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	562					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					ATAAGAATTCTTTCTTTATGG	0.373													10	10					0	0	0	0	A	50052855	A	A	50052855	2	1	166	1	0	0	0	0	0	0	0	1	2929	1596	56	5		5	CCNB3	23	50052855	Silent	SNP	T	TCGA-CR-7402-01A-11D-2012-08	910188	50052855	105217705	1049	31377											
CCNB3	85417	broad.mit.edu	37	chrX	50053222	50053222	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatgttaagcataccaacAaaagtgggtccctcttccag	12	10	8	11	0	1	0	0	0	1	0	3	0	3	0	3	1	4	3	3	1	5	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:50053222A>C	uc004dox.3	+	6	2351	c.2053A>C	c.(2053-2055)AAA>CAA	p.K685Q	CCNB3_uc004doy.2_Missense_Mutation_p.K685Q|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	685					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GCATACCAACAAAAGTGGGTC	0.463													10	10					0	0	0	0	C	50053222	C	C	50053222	3	2	166	1	0	0	0	0	1	0	0	0	2929	131	5	5	2067	5	CCNB3	23	50053222	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	367	50053222	105217338	1050	31378											
TRO	7216	broad.mit.edu	37	chrX	54949662	54949662	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caactgccacccatacagctAccacccaaggccaaattacc	14	5	4	18	0	0	0	0	0	0	0	0	0	0	0	6	1	6	1	6	1	6	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:54949662A>G	uc004dtq.2	+	3	804	c.697A>G	c.(697-699)ACC>GCC	p.T233A	TRO_uc011moj.1_Missense_Mutation_p.T176A|TRO_uc004dts.2_Missense_Mutation_p.T233A|TRO_uc004dtr.2_Missense_Mutation_p.T233A|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Intron|TRO_uc004dtw.2_Intron|TRO_uc004dtx.2_5'Flank	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	233					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						CCATACAGCTACCACCCAAGG	0.512													23	11					0	0	0	0	G	54949662	G	G	54949662	3	3	166	1	0	0	0	0	1	0	0	0	16641	391	14	5	703	5	TRO	23	54949662	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	4896440	54949662	100320898	1051	31379											
ZMYM3	9203	broad.mit.edu	37	chrX	70469326	70469327	+	Frame_Shift_Ins	INS	-	T	T																															ccaccttcttgtacgcccccINSaagcaggttgtgttgcagaa																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:70469326_70469327insT	uc004dzh.1	-	7	1541_1542	c.1454_1455insA	c.(1453-1455)TTGfs	p.L485fs	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Frame_Shift_Ins_p.L485fs|ZMYM3_uc004dzj.1_Frame_Shift_Ins_p.L485fs|ZMYM3_uc011mpu.1_Frame_Shift_Ins_p.L216fs|ZMYM3_uc004dzk.3_Frame_Shift_Ins_p.L485fs|ZMYM3_uc004dzl.3_Frame_Shift_Ins_p.L485fs|ZMYM3_uc004dzm.3_Frame_Shift_Ins_p.L485fs	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	485	MYM-type 4.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TGTACGCCCCCAAGCAGGTTGT	0.564													---	---	---								T	70469327	T	T	70469326	7	5	166	1	0	1	1	0	0	0	0	0	17768	593	21	0	2751	0	ZMYM3	23	70469326	Frame_Shift_Ins	INS	-	TCGA-CR-7402-01A-11D-2012-08	15519664	70469326	84801234	1052	31380											
TBX22	50945	broad.mit.edu	37	chrX	79286337	79286337	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttcatctgaagactccagTgatcagtatctacaagcacc	12	10	8	11	0	4	3	2	2	2	1	5	3	5	3	2	1	2	3	2	1	4	3	rs144871606	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:79286337T>G	uc010nmg.1	+	9	1424	c.1290T>G	c.(1288-1290)AGT>AGG	p.S430R	TBX22_uc004edi.1_Missense_Mutation_p.S310R|TBX22_uc004edj.1_Missense_Mutation_p.S430R	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	430					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						AAGACTCCAGTGATCAGTATC	0.433													41	36					0	0	0	0	G	79286337	G	G	79286337	3	3	166	1	0	0	0	0	1	0	0	0	15724	1693	59	5	1320	5	TBX22	23	79286337	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	8817011	79286337	75984223	1053	31381											
CSTF2	1478	broad.mit.edu	37	chrX	100088319	100088319	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccgagcgatggaggcccGtgcaatggaagtccgaggga	9	4	18	10	4	0	0	0	0	0	0	1	6	1	3	3	5	2	1	3	5	2	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:100088319G>T	uc004egh.2	+	11	1416	c.1358G>T	c.(1357-1359)CGT>CTT	p.R453L	CSTF2_uc010nnd.2_Missense_Mutation_p.R473L|CSTF2_uc004egi.2_Missense_Mutation_p.R436L	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	453	9.|12 X 5 AA tandem repeats of M-E-A-R-[AG].				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						ATGGAGGCCCGTGCAATGGAA	0.612													5	5					1.024e-07	1.87399e-07	1	0	T	100088319	T	T	100088319	3	4	166	1	0	0	0	0	1	0	0	0	4001	1145	40	3	1400	3	CSTF2	23	100088319	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	20801982	100088319	55182241	1054	31382											
ESX1	80712	broad.mit.edu	37	chrX	103495025	103495025	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggcgccatgggcggccCgggtggcagaggcgccatgg	6	3	20	12	4	0	2	0	0	0	2	0	2	0	2	3	7	0	1	3	7	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:103495025C>A	uc004ely.2	-	4	1163	c.1105G>T	c.(1105-1107)GGG>TGG	p.G369W		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	369	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.|14.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ATGGGCGGCCCGGGTGGCAGA	0.701													11	11					0.000673444	0.00110641	1	0	A	103495025	A	A	103495025	3	1	166	1	0	0	0	0	1	0	0	0	5287	652	23	3	119	3	ESX1	23	103495025	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	3406706	103495025	51775535	1055	31383											
TRPC5	7224	broad.mit.edu	37	chrX	111078301	111078301	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgacatatagatttaaaaGgccaaatacagaccagaaga	19	7	9	6	0	0	5	0	1	0	4	0	5	0	5	2	2	1	0	2	2	7	5			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:111078301G>T	uc004epl.1	-	7	2663	c.1744C>A	c.(1744-1746)CTT>ATT	p.L582I	TRPC5_uc004epm.1_Missense_Mutation_p.L582I	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	582	Extracellular (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						AGATTTAAAAGGCCAAATACA	0.398													110	65					1.93806e-58	4.93967e-58	1	0	T	111078301	T	T	111078301	3	4	166	1	0	0	0	0	1	0	0	0	16649	1000	35	4	1197	4	TRPC5	23	111078301	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	7583276	111078301	44192259	1056	31384											
ODZ1	10178	broad.mit.edu	37	chrX	123805537	123805537	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttgatcactgtacctttTttctctgatttatcagaaac	10	19	4	8	0	3	3	2	2	1	1	4	3	3	3	1	0	2	1	1	0	3	8			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:123805537T>A	uc004euj.2	-	6	1228	c.1164A>T	c.(1162-1164)AAA>AAT	p.K388N	ODZ1_uc011muj.1_Missense_Mutation_p.K387N|ODZ1_uc010nqy.2_Missense_Mutation_p.K388N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	388	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTGTACCTTTTTTCTCTGATT	0.373													37	24					0	0	0	0	A	123805537	A	A	123805537	3	1	166	1	0	0	0	0	1	0	0	0	10888	1838	64	5	7142	5	ODZ1	23	123805537	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	12727236	123805537	31465023	1057	31385											
DCAF12L1	139170	broad.mit.edu	37	chrX	125686094	125686094	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgttggggttttcgccgccGgtggccagaagcgtcttgga	4	11	16	10	4	1	1	0	0	1	1	2	2	1	2	3	5	1	2	3	5	1	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:125686094G>T	uc004eul.2	-	1	749	c.498C>A	c.(496-498)ACC>ACA	p.T166T		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	166	WD 1.									skin(3)|ovary(1)	4						TTTCGCCGCCGGTGGCCAGAA	0.657													22	7					3.62473e-10	7.02718e-10	1	0	T	125686094	T	T	125686094	2	4	166	1	0	0	0	0	0	0	0	1	4281	1103	39	3		3	DCAF12L1	23	125686094	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	1880557	125686094	29584466	1058	31386											
GPR101	83550	broad.mit.edu	37	chrX	136112422	136112422	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcttttccttgcagaagaacTtcttcagcatgtcctggatt	8	15	8	10	0	2	2	1	0	1	2	4	3	4	3	2	1	3	3	2	1	2	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:136112422T>A	uc011mwh.1	-	1	1412	c.1412A>T	c.(1411-1413)AAG>ATG	p.K471M		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	471	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GCAGAAGAACTTCTTCAGCAT	0.493													39	20					0	0	0	0	A	136112422	A	A	136112422	3	1	166	1	0	0	0	0	1	0	0	0	6660	1609	56	5	117	5	GPR101	23	136112422	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	10426328	136112422	19158138	1059	31387											
F9	2158	broad.mit.edu	37	chrX	138642993	138642993	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccactgtgttgaaactggtGttaaaattacagttgtcgca	11	13	9	8	1	0	1	0	1	0	0	1	1	0	1	1	1	2	4	1	1	4	4			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:138642993G>A	uc004fas.1	+	7	846	c.817G>A	c.(817-819)GTT>ATT	p.V273I	F9_uc004fat.1_Missense_Mutation_p.V235I	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	273	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGAAACTGGTGTTAAAATTAC	0.368													7	42					0	0	0	0	A	138642993	A	A	138642993	3	1	166	1	0	0	0	0	1	0	0	0	5379	1377	48	4	843	4	F9	23	138642993	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2530571	138642993	16627567	1060	31388											
SPANXE	171489	broad.mit.edu	37	chrX	140785676	140785676	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aattcctcctcctccatttgGagggggttgattctgttctt	5	17	9	10	0	2	1	0	1	2	0	6	2	6	2	4	3	0	2	4	3	1	6			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:140785676G>T	uc004fbq.2	-	2	333	c.240C>A	c.(238-240)CTC>CTA	p.L80L		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	SPANX family, member E	80						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					CCTCCATTTGGAGGGGGTTGA	0.443													105	132					1.62402e-62	4.14465e-62	1	0	T	140785676	T	T	140785676	2	4	166	1	0	0	0	0	0	0	0	1	15055	1161	41	2		2	SPANXE	23	140785676	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	2142683	140785676	14484884	1061	31389											
MAGEC2	51438	broad.mit.edu	37	chrX	141291747	141291747	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagtcgttgtcaacgttgcgGaatggaacgcctggaacggg	9	8	16	8	5	1	0	1	0	0	0	2	4	1	3	1	4	4	2	1	4	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:141291747G>A	uc004fbu.1	-	3	375	c.27C>T	c.(25-27)TTC>TTT	p.F9F		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	9						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CAACGTTGCGGAATGGAACGC	0.537										HNSCC(46;0.14)			49	32					0	0	0	0	A	141291747	A	A	141291747	2	1	166	1	0	0	0	0	0	0	0	1	9234	1165	41	2		2	MAGEC2	23	141291747	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	506071	141291747	13978813	1062	31390											
IDS	3423	broad.mit.edu	37	chrX	148564745	148564745	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tccacaaggtccatggattgCctgcctgaaacaggaagcga	12	7	11	11	1	0	1	0	1	0	0	2	4	2	3	4	3	4	0	4	3	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:148564745C>A	uc011mxe.1	-	9	1383	c.1185G>T	c.(1183-1185)AGG>AGT	p.R395S	IDS_uc011mxd.1_5'UTR|IDS_uc011mxf.1_Missense_Mutation_p.R305S|IDS_uc011mxg.1_Missense_Mutation_p.R184S|IDS_uc010nsu.1_Missense_Mutation_p.R5S|IDS_uc004fcw.3_Missense_Mutation_p.R184S	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	395						lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CCATGGATTGCCTGCCTGAAA	0.532													11	9					4.68919e-08	8.62987e-08	1	0	A	148564745	A	A	148564745	3	1	166	1	0	0	0	0	1	0	0	0	7542	738	26	4	471	4	IDS	23	148564745	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	7272998	148564745	6705815	1063	31391											
PASD1	139135	broad.mit.edu	37	chrX	150840977	150840977	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagagggtgcagatatgccTgcaaaacccacgtgacgtat	12	8	12	9	2	0	3	0	2	0	2	0	4	0	3	2	1	4	3	2	1	4	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:150840977T>A	uc004fev.3	+	14	2092	c.1760T>A	c.(1759-1761)CTG>CAG	p.L587Q		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	587						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAGATATGCCTGCAAAACCCA	0.348													30	16					0	0	0	0	A	150840977	A	A	150840977	3	1	166	1	0	0	0	0	1	0	0	0	11525	1580	55	5	1810	5	PASD1	23	150840977	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	2276232	150840977	4429583	1064	31392											
MAGEA4	4103	broad.mit.edu	37	chrX	151092986	151092986	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggctctggctgaaaccagcTatgtgaaagtcctggagcat	10	9	13	9	0	1	2	0	2	1	0	2	3	2	3	2	3	3	4	2	3	3	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:151092986T>A	uc004fez.2	+	3	1006	c.850T>A	c.(850-852)TAT>AAT	p.Y284N	MAGEA4_uc004ffa.2_Missense_Mutation_p.Y284N|MAGEA4_uc004ffb.2_Missense_Mutation_p.Y284N|MAGEA4_uc004ffc.2_Missense_Mutation_p.Y284N|MAGEA4_uc004ffd.2_Missense_Mutation_p.Y284N	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	284	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGAAACCAGCTATGTGAAAGT	0.552													85	59					0	0	0	0	A	151092986	A	A	151092986	3	1	166	1	0	0	0	0	1	0	0	0	9219	1522	53	5	852	5	MAGEA4	23	151092986	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	252009	151092986	4177574	1065	31393											
MAGEA12	4111	broad.mit.edu	37	chrX	151896605	151896605	+	RNA	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggacaatgggctggaggctCgtggtttcctggacatcttc	6	12	14	9	1	1	0	0	0	1	0	4	3	2	3	1	6	0	3	1	6	1	2			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:151896605C>T	uc004fgb.2	-	3		c.372G>A						P43365	MAGAC_HUMAN	Homo sapiens melanoma antigen family A, 12, mRNA (cDNA clone MGC:4914 IMAGE:3450217), complete cds.											skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GCTGGAGGCTCGTGGTTTCCT	0.517													62	46					0	0	0	0	T	151896605	T	T	151896605	1	4	166	0	1	0	0	0	0	0	0	0	9217	899	31	1		1	MAGEA12	23	151896605	RNA	SNP	C	TCGA-CR-7402-01A-11D-2012-08	803619	151896605	3373955	1066	31394											
DUSP9	1852	broad.mit.edu	37	chrX	152915660	152915660	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggaggagcgccactcgcAggagcagggcagtggggggc	7	3	21	10	2	0	0	0	0	0	0	1	3	0	3	1	7	2	4	1	7	0	0			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:152915660A>C	uc004fhx.3	+	4	1259	c.1055A>C	c.(1054-1056)CAG>CCG	p.Q352P	DUSP9_uc004fhy.3_Missense_Mutation_p.Q352P	NM_001395	NP_001386	Q99956	DUS9_HUMAN	dual specificity phosphatase 9	352	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGCCACTCGCAGGAGCAGGGC	0.632													40	36					0	0	0	0	C	152915660	C	C	152915660	3	2	166	1	0	0	0	0	1	0	0	0	4854	188	7	5	1065	5	DUSP9	23	152915660	Missense_Mutation	SNP	A	TCGA-CR-7402-01A-11D-2012-08	1019055	152915660	2354900	1067	31395											
L1CAM	3897	broad.mit.edu	37	chrX	153132315	153132315	+	Frame_Shift_Del	DEL	C	-	-																															tggggggcgttccagtccatCcaccggagcggctggaggag																										TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:153132315delC	uc004fjb.2	-	18	2328	c.2220delG	c.(2218-2220)TGGfs	p.W740fs	L1CAM_uc004fjc.2_Frame_Shift_Del_p.W740fs|L1CAM_uc010nuo.2_Frame_Shift_Del_p.W735fs	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	740	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGTCCATCCACCGGAGCG	0.652													---	---	---								-	153132315	-	-	153132315	7	5	166	1	0	1	0	1	0	0	0	0	8628	856	30	0	1597	0	L1CAM	23	153132315	Frame_Shift_Del	DEL	C	TCGA-CR-7402-01A-11D-2012-08	216655	153132315	2138245	1068	31396											
TSPY2	64591	broad.mit.edu	37	chrY	6114391	6114391	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcgtgggtcgggcagcacagGccttggtgtgtgcgagtgcc	4	8	19	10	3	0	0	0	0	0	0	1	1	0	0	2	4	3	2	2	4	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:6114391G>T	uc004fqr.1	+	1	128	c.82G>T	c.(82-84)GCC>TCC	p.A28S	TTTY23_uc004fqq.1_5'Flank|TSPY2_uc004fqs.1_Missense_Mutation_p.A28S	NM_022573	NP_072095	A6NKD2	TSPY2_HUMAN	testis specific protein, Y-linked 2	28					cell differentiation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus					0						GGCAGCACAGGCCTTGGTGTG	0.711													15	9					2.48551e-13	5.10649e-13	1	0	T	6114391	T	T	6114391	3	4	166	1	0	0	0	0	1	0	0	0	16725	1203	42	4	84	4	TSPY2	24	6114391	Missense_Mutation	SNP	G	TCGA-CR-7402-01A-11D-2012-08		6114391	53259175	1069	31397											
AMELY	266	broad.mit.edu	37	chrY	6736363	6736363	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcatcagtgcttgctggcgGaccctgggctgctgagctgg	4	9	17	11	1	1	1	1	1	0	0	1	2	1	2	1	5	4	6	1	5	0	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:6736363G>T	uc004fra.1	-	5	342	c.330C>A	c.(328-330)GTC>GTA	p.V110V	AMELY_uc004fqz.2_Silent_p.V96V	NM_001143	NP_001134	Q99218	AMELY_HUMAN	amelogenin, Y-linked precursor	110	Gln-rich.				biomineral tissue development	proteinaceous extracellular matrix	structural constituent of tooth enamel				0						CTTGCTGGCGGACCCTGGGCT	0.612													32	25					1.22384e-17	2.7635e-17	1	0	T	6736363	T	T	6736363	2	4	166	1	0	0	0	0	0	0	0	1	570	1161	41	2		2	AMELY	24	6736363	Silent	SNP	G	TCGA-CR-7402-01A-11D-2012-08	621972	6736363	52637203	1070	31398											
TBL1Y	90665	broad.mit.edu	37	chrY	6958154	6958154	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtctcgtccacagctacCaaggcactggcggtatcttc	9	9	10	13	2	2	0	0	0	2	0	5	1	3	0	2	3	2	3	2	3	4	3			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:6958154C>A	uc004frb.2	+	18	2118	c.1471C>A	c.(1471-1473)CAA>AAA	p.Q491K	TBL1Y_uc004frc.2_Missense_Mutation_p.Q491K|TBL1Y_uc004frd.2_Missense_Mutation_p.Q491K|TBL1Y_uc011nap.1_Missense_Mutation_p.Q333K	NM_033284	NP_150600	Q9BQ87	TBL1Y_HUMAN	transducin beta-like 1Y	491	WD 8.				transcription, DNA-dependent						0						CCACAGCTACCAAGGCACTGG	0.532													11	11					7.03913e-09	1.32406e-08	1	0	A	6958154	A	A	6958154	3	1	166	1	0	0	0	0	1	0	0	0	15707	595	21	4	1521	4	TBL1Y	24	6958154	Missense_Mutation	SNP	C	TCGA-CR-7402-01A-11D-2012-08	221791	6958154	52415412	1071	31399											
KDM5D	8284	broad.mit.edu	37	chrY	21869833	21869833	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttaccacagagcctgggTctctgaggtcctgtgcagac	7	10	11	13	0	1	3	0	1	1	2	4	3	3	3	4	2	3	1	4	2	1	1			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:21869833T>A	uc004fug.2	-	23	3674	c.3386A>T	c.(3385-3387)GAC>GTC	p.D1129V	KDM5D_uc011naz.1_Missense_Mutation_p.D1160V|KDM5D_uc010nwy.2_Missense_Mutation_p.D1072V|KDM5D_uc004fuf.2_Missense_Mutation_p.D304V	NM_004653	NP_004644	Q9BY66	KDM5D_HUMAN	jumonji, AT rich interactive domain 1D isoform	1129					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1					Vitamin C(DB00126)	AGAGCCTGGGTCTCTGAGGTC	0.577													12	11					0	0	0	0	A	21869833	A	A	21869833	3	1	166	1	0	0	0	0	1	0	0	0	8175	1667	58	5	1253	5	KDM5D	24	21869833	Missense_Mutation	SNP	T	TCGA-CR-7402-01A-11D-2012-08	14911679	21869833	37503733	1072	31400											
C1orf187	374946	broad.mit.edu	37	chr1	11775204	11775204	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcgacctgcgggagcatctCtgcacaccccacaaccgagg	9	5	11	16	3	1	0	0	0	1	0	2	3	1	1	4	2	5	2	4	2	1	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:11775204C>G	uc001asr.1	+	6	1016	c.876C>G	c.(874-876)CTC>CTG	p.L292L		NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor	292					axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		GGGAGCATCTCTGCACACCCC	0.622													19	63					0	0	0	0	G	11775204	G	G	11775204	2	3	167	1	0	0	0	0	0	0	0	1	2030	900	32	2		2	C1orf187	1	11775204	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08		11775204	237475417	1	31401											
EIF4G3	8672	broad.mit.edu	37	chr1	21268030	21268030	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagttttgagaatccaaaatCtcttctgtttgcccatctgc	10	15	6	10	0	3	1	0	1	3	1	5	2	4	1	2	0	2	2	2	0	4	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:21268030C>T	uc001bec.2	-	9	1705	c.1449G>A	c.(1447-1449)GAG>GAA	p.E483E	EIF4G3_uc010odi.1_Silent_p.E87E|EIF4G3_uc010odj.1_Silent_p.E482E|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Silent_p.E483E|EIF4G3_uc001bef.2_Silent_p.E482E|EIF4G3_uc001bee.2_Silent_p.E489E|EIF4G3_uc001beg.2_Silent_p.E482E|EIF4G3_uc010odk.1_Silent_p.E483E|EIF4G3_uc001beh.2_Silent_p.E494E	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	483					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		AATCCAAAATCTCTTCTGTTT	0.433													30	170					0	0	0	0	T	21268030	T	T	21268030	2	4	167	1	0	0	0	0	0	0	0	1	5062	912	32	2		2	EIF4G3	1	21268030	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	9492826	21268030	227982591	2	31402											
ZBTB8A	653121	broad.mit.edu	37	chr1	33065908	33065908	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcacttgagtgaagatgAgaatagatcctatgtggaga	14	10	13	4	0	0	6	0	3	0	4	1	8	1	6	1	2	0	1	1	2	4	3	rs147884621	byFrequency	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:33065908A>C	uc001bvn.2	+	5	1699	c.1214A>C	c.(1213-1215)GAG>GCG	p.E405A	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_3'UTR|ZBTB8OS_uc001bvo.1_RNA	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGTGAAGATGAGAATAGATCC	0.428													5	44					0	0	0	0	C	33065908	C	C	33065908	3	2	167	1	0	0	0	0	1	0	0	0	17623	304	11	5	1224	5	ZBTB8A	1	33065908	Missense_Mutation	SNP	A	TCGA-CR-7404-01A-11D-2129-08	11797878	33065908	216184713	3	31403											
CYP4B1	1580	broad.mit.edu	37	chr1	47282750	47282750	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaaaatgacttatctgacCatgtgcatcaaggagagctt	13	10	10	8	0	2	3	1	2	1	1	2	4	2	3	1	2	2	3	1	2	4	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:47282750C>G	uc001cqm.3	+	9	1185	c.1101C>G	c.(1099-1101)ACC>ACG	p.T367T	CYP4B1_uc001cqn.3_Silent_p.T368T|CYP4B1_uc009vym.2_Silent_p.T353T|CYP4B1_uc010omk.1_Silent_p.T204T	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	367					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CTTATCTGACCATGTGCATCA	0.547													22	97					0	0	0	0	G	47282750	G	G	47282750	2	3	167	1	0	0	0	0	0	0	0	1	4202	581	21	4		4	CYP4B1	1	47282750	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	14216842	47282750	201967871	4	31404											
HFM1	164045	broad.mit.edu	37	chr1	91817197	91817197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactgcagtagctgtagtgtCaaactggggagaaaacaaac	16	7	11	7	0	1	1	1	0	0	1	1	2	1	1	0	2	6	4	0	2	7	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:91817197C>T	uc001doa.3	-	17	2081	c.1981G>A	c.(1981-1983)GAC>AAC	p.D661N	HFM1_uc009wdb.2_Intron|HFM1_uc010osu.1_Missense_Mutation_p.D340N|HFM1_uc010osv.1_Missense_Mutation_p.D345N	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	661	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GCTGTAGTGTCAAACTGGGGA	0.378													16	65					0	0	0	0	T	91817197	T	T	91817197	3	4	167	1	0	0	0	0	1	0	0	0	7122	826	29	2	2418	2	HFM1	1	91817197	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	44534447	91817197	157433424	5	31405											
OLFM3	118427	broad.mit.edu	37	chr1	102290711	102290711	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agacagattccttatttcctCcttgaactgggtgattaact	10	15	7	9	0	0	4	0	2	0	2	3	4	3	4	3	1	2	0	3	1	3	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:102290711C>G	uc001duf.2	-	4	594	c.523G>C	c.(523-525)GAG>CAG	p.E175Q	OLFM3_uc001dug.2_Missense_Mutation_p.E155Q|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.E80Q|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	175	Potential.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CTTATTTCCTCCTTGAACTGG	0.458													7	26					0	0	0	0	G	102290711	G	G	102290711	3	3	167	1	0	0	0	0	1	0	0	0	10908	864	30	2	925	2	OLFM3	1	102290711	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	10473514	102290711	146959910	6	31406											
FLG	2312	broad.mit.edu	37	chr1	152279707	152279707	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcctgggcccctctgattgtCcctggcccacctgcgagtgt	3	11	11	16	1	1	1	0	1	1	0	3	2	3	1	6	2	1	0	6	2	0	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:152279707C>T	uc001ezu.1	-	3	7691	c.7655G>A	c.(7654-7656)GGA>GAA	p.G2552E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2552	Ser-rich.|Filaggrin 15.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTGATTGTCCCTGGCCCAC	0.592									Ichthyosis				13	330					0	0	0	0	T	152279707	T	T	152279707	3	4	167	1	0	0	0	0	1	0	0	0	5954	855	30	2	4534	2	FLG	1	152279707	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	49988996	152279707	96970914	7	31407											
NUP210L	91181	broad.mit.edu	37	chr1	154018842	154018842	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacaacttcaatctgtacttCatcctgctcaacagggtgga	12	11	7	11	0	4	0	3	0	1	0	5	1	5	1	1	2	5	2	1	2	5	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:154018842C>T	uc001fdw.2	-	26	3559	c.3487G>A	c.(3487-3489)GAA>AAA	p.E1163K	NUP210L_uc009woq.2_Missense_Mutation_p.E72K|NUP210L_uc010peh.1_Missense_Mutation_p.E1163K	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1163						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ATCTGTACTTCATCCTGCTCA	0.463													7	36					0	0	0	0	T	154018842	T	T	154018842	3	4	167	1	0	0	0	0	1	0	0	0	10815	835	29	2	2239	2	NUP210L	1	154018842	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	1739135	154018842	95231779	8	31408											
GON4L	54856	broad.mit.edu	37	chr1	155720453	155720453	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctggtactggttgcatcAtcctcatcctcagagctggc	6	13	10	12	0	3	1	3	0	0	1	5	1	5	1	2	3	4	5	2	3	1	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:155720453A>G	uc001flz.2	-	32	6745	c.6648T>C	c.(6646-6648)GAT>GAC	p.D2216D	MSTO2P_uc010pgp.1_RNA|GON4L_uc001flx.1_Silent_p.D50D|GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Silent_p.D2215D|GON4L_uc009wrh.1_Silent_p.D2215D|GON4L_uc001fma.1_Silent_p.D2216D	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	2216					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TGGTTGCATCATCCTCATCCT	0.512													3	13					0	0	0	0	G	155720453	G	G	155720453	2	3	167	1	0	0	0	0	0	0	0	1	6609	214	8	5		5	GON4L	1	155720453	Silent	SNP	A	TCGA-CR-7404-01A-11D-2129-08	1701611	155720453	93530168	9	31409											
HSPA6	3310	broad.mit.edu	37	chr1	161495705	161495705	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accacgctgatccagaggaaCgccactatccccaccaagca	13	4	7	17	2	0	2	0	1	0	1	2	3	2	3	6	1	2	2	6	1	3	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:161495705C>T	uc001gap.2	+	2	1917	c.1257C>T	c.(1255-1257)AAC>AAT	p.N419N	HSPA6_uc001gaq.2_Silent_p.N419N	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	419					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TCCAGAGGAACGCCACTATCC	0.582													4	33					0	0	0	0	T	161495705	T	T	161495705	2	4	167	1	0	0	0	0	0	0	0	1	7454	535	19	1		1	HSPA6	1	161495705	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	5775252	161495705	87754916	10	31410											
UCK2	7371	broad.mit.edu	37	chr1	165877020	165877020	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caacggctacaccccttcacGcaagaggcaggcatcggagt	11	5	11	14	3	1	1	1	0	0	1	2	2	1	2	2	4	2	4	2	4	3	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:165877020G>A	uc001gdp.2	+	7	927	c.746G>A	c.(745-747)CGC>CAC	p.R249H	UCK2_uc010plb.1_Missense_Mutation_p.R111H	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	249					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					ACCCCTTCACGCAAGAGGCAG	0.612													22	87					0	0	0	0	A	165877020	A	A	165877020	3	1	167	1	0	0	0	0	1	0	0	0	16992	1087	38	1	772	1	UCK2	1	165877020	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	4381315	165877020	83373601	11	31411											
DCAF6	55827	broad.mit.edu	37	chr1	168037616	168037616	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttataactcgaaacgaactCatgctggaagaaactagaaa	18	8	8	7	2	1	2	1	0	0	2	2	5	1	3	0	1	5	2	0	1	8	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:168037616C>T	uc001gew.2	+	18	2675	c.2433C>T	c.(2431-2433)CTC>CTT	p.L811L	DCAF6_uc001gev.2_Silent_p.L831L|DCAF6_uc001gex.2_Silent_p.L902L|DCAF6_uc010plk.1_Silent_p.L871L|DCAF6_uc001gey.2_Silent_p.L684L|DCAF6_uc001gez.2_Silent_p.L114L	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	811					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GAAACGAACTCATGCTGGAAG	0.373													9	49					0	0	0	0	T	168037616	T	T	168037616	2	4	167	1	0	0	0	0	0	0	0	1	4291	813	29	2		2	DCAF6	1	168037616	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	2160596	168037616	81213005	12	31412											
XCL2	6846	broad.mit.edu	37	chr1	168511261	168511261	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaaggagccttccgtgatgGtgtaggtcttgattctgcta	7	14	12	8	1	3	2	1	2	2	0	4	3	4	3	2	3	2	2	2	3	3	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:168511261G>C	uc001gfn.3	-	2	179	c.146C>G	c.(145-147)ACC>AGC	p.T49S		NM_003175	NP_003166	Q9UBD3	XCL2_HUMAN	chemokine (C motif) ligand 2 precursor	49					blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity			ovary(1)	1	all_hematologic(923;0.215)					TTCCGTGATGGTGTAGGTCTT	0.488													4	45					0	0	0	0	C	168511261	C	C	168511261	3	2	167	1	0	0	0	0	1	0	0	0	17492	1261	44	4	206	4	XCL2	1	168511261	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	473645	168511261	80739360	13	31413											
XCL1	6375	broad.mit.edu	37	chr1	168549385	168549385	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tagcagaatcaagacctacaCcatcacggaaggctccttga	14	7	8	12	1	2	3	2	1	0	2	3	4	3	4	3	2	2	2	3	2	5	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:168549385C>G	uc001gfo.1	+	2	166	c.146C>G	c.(145-147)ACC>AGC	p.T49S		NM_002995	NP_002986	P47992	XCL1_HUMAN	chemokine (C motif) ligand 1	49					CD4-positive, alpha-beta T cell proliferation|CD8-positive, alpha-beta T cell proliferation|cell-cell signaling|cellular response to interleukin-4|cellular response to transforming growth factor beta stimulus|immunoglobulin production in mucosal tissue|lymphocyte chemotaxis|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell cytokine production|negative regulation of T-helper 1 cell activation|negative regulation of transcription, DNA-dependent|neutrophil chemotaxis|positive regulation of activated T cell proliferation|positive regulation of B cell chemotaxis|positive regulation of granzyme A production|positive regulation of granzyme B production|positive regulation of interleukin-10 production|positive regulation of natural killer cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell chemotaxis|positive regulation of T cell cytokine production|positive regulation of T cell mediated cytotoxicity|positive regulation of thymocyte migration|positive regulation of transforming growth factor-beta production|regulation of inflammatory response|release of sequestered calcium ion into cytosol|response to virus|T-helper 1 cell cytokine production|T-helper 2 cell cytokine production	extracellular space	chemokine activity|protein homodimerization activity				0	all_hematologic(923;0.208)					AAGACCTACACCATCACGGAA	0.483													12	102					0	0	0	0	G	168549385	G	G	168549385	3	3	167	1	0	0	0	0	1	0	0	0	17491	507	18	4	152	4	XCL1	1	168549385	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	38124	168549385	80701236	14	31414											
FAM20B	9917	broad.mit.edu	37	chr1	179013306	179013306	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttataaagggacacagctGaaagccttactgatacttga	14	10	10	7	0	0	3	0	3	0	0	0	4	0	4	1	2	4	2	1	2	6	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:179013306G>A	uc001gmc.2	+	2	617	c.324G>A	c.(322-324)CTG>CTA	p.L108L		NM_014864	NP_055679	O75063	XYLK_HUMAN	hypothetical protein LOC9917 precursor	108	Lumenal (Potential).					Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(3)	3						GGACACAGCTGAAAGCCTTAC	0.448													8	51					0	0	0	0	A	179013306	A	A	179013306	2	1	167	1	0	0	0	0	0	0	0	1	5566	1277	45	2		2	FAM20B	1	179013306	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	10463921	179013306	70237315	15	31415											
NCF2	4688	broad.mit.edu	37	chr1	183529328	183529328	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctccacttggctgcctttCttaagctgaggttctgttgt	4	16	10	11	0	2	1	0	1	2	0	3	1	3	1	3	2	2	4	3	2	1	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:183529328C>G	uc001gqj.3	-	14	1646	c.1371G>C	c.(1369-1371)AAG>AAC	p.K457N	NCF2_uc010pod.1_Missense_Mutation_p.K412N|NCF2_uc010poe.1_Missense_Mutation_p.K376N|NCF2_uc001gqk.3_Missense_Mutation_p.K457N	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	457	SH3 2.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						GGCTGCCTTTCTTAAGCTGAG	0.463													7	167					0	0	0	0	G	183529328	G	G	183529328	3	3	167	1	0	0	0	0	1	0	0	0	10271	912	32	2	217	2	NCF2	1	183529328	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	4516022	183529328	65721293	16	31416											
CNST	163882	broad.mit.edu	37	chr1	246810955	246810956	+	Nonsense_Mutation	DNP	GC	CT	CT																															aacaatgaattaaatgagctGcagcagcctgatcttacaga																										TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:246810955_246810956GC>CT	uc001ibp.2	+	9	1830_1831	c.1452_1453GC>CT	c.(1450-1455)CTGCAG>CTCTAG	p.Q485*	CNST_uc001ibo.3_Nonsense_Mutation_p.Q485*	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	485					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						TAAATGAGCTGCAGCAGCCTGA	0.465													15	80					0	0	0	0	CT	246810956	CT	CT	246810955	4	2	167	1	0	0	0	0	0	1	0	0	3649	1306	46	4	1482	4	CNST	1	246810955	Nonsense_Mutation	DNP	GC	TCGA-CR-7404-01A-11D-2129-08	63281627	246810955	2439666	17	31417											
OR2G2	81470	broad.mit.edu	37	chr1	247752501	247752501	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaagtttgtttctctcttCtacactgtggtaacccgcat	7	15	8	11	1	3	0	0	0	3	0	4	0	3	0	1	2	2	5	1	2	3	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr1:247752501C>T	uc010pyy.1	+	1	840	c.840C>T	c.(838-840)TTC>TTT	p.F280F		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTTCTCTCTTCTACACTGTGG	0.363													12	152					0	0	0	0	T	247752501	T	T	247752501	2	4	167	1	0	0	0	0	0	0	0	1	11052	912	32	2		2	OR2G2	1	247752501	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	941546	247752501	1498120	18	31418											
KIDINS220	57498	broad.mit.edu	37	chr2	8934023	8934023	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgcctgctttgttgggcctaTaaagtaatcgcccatctttg	7	14	9	11	2	1	0	0	0	1	0	2	0	1	0	3	1	1	3	3	1	4	6			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:8934023T>C	uc002qzc.2	-	12	1375	c.1193A>G	c.(1192-1194)TAT>TGT	p.Y398C	KIDINS220_uc010yiv.1_Missense_Mutation_p.Y164C|KIDINS220_uc002qzd.2_Missense_Mutation_p.Y356C|KIDINS220_uc010yiw.1_Missense_Mutation_p.Y399C	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	398	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTTGGGCCTATAAAGTAATCG	0.403													15	46					0	0	0	0	C	8934023	C	C	8934023	3	2	167	1	0	0	0	0	1	0	0	0	8310	1406	49	5	4198	5	KIDINS220	2	8934023	Missense_Mutation	SNP	T	TCGA-CR-7404-01A-11D-2129-08		8934023	234265350	19	31419											
SLC8A1	6546	broad.mit.edu	37	chr2	40655980	40655980	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcctcaaagatatcatcatCtatgatacccactctgattt	12	14	3	12	0	5	3	3	2	2	1	6	3	6	3	2	0	1	0	2	0	4	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:40655980C>G	uc002rrx.2	-	1	1465	c.1441G>C	c.(1441-1443)GAT>CAT	p.D481H	SLC8A1_uc002rry.2_Missense_Mutation_p.D481H|SLC8A1_uc002rrz.2_Missense_Mutation_p.D481H|SLC8A1_uc002rsa.2_Missense_Mutation_p.D481H|SLC8A1_uc002rsd.3_Missense_Mutation_p.D481H|SLC8A1_uc002rsb.1_Missense_Mutation_p.D481H|SLC8A1_uc010fan.1_Missense_Mutation_p.D481H|SLC8A1_uc002rsc.1_Missense_Mutation_p.D481H	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	481	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ATATCATCATCTATGATACCC	0.418													4	59					0	0	0	0	G	40655980	G	G	40655980	3	3	167	1	0	0	0	0	1	0	0	0	14770	913	32	2	1628	2	SLC8A1	2	40655980	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	31721957	40655980	202543393	20	31420											
BCL11A	53335	broad.mit.edu	37	chr2	60688312	60688312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaagtgtccctgtggccctCggcctcggccaggtggccgc	3	7	15	16	3	0	0	0	0	0	0	3	0	1	0	5	5	0	1	5	5	1	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:60688312C>T	uc002sae.1	-	4	1963	c.1735G>A	c.(1735-1737)GAG>AAG	p.E579K	BCL11A_uc002sab.2_Missense_Mutation_p.E579K|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.E248K|BCL11A_uc010ypj.1_Missense_Mutation_p.E545K|BCL11A_uc002sad.1_Missense_Mutation_p.E427K|BCL11A_uc002saf.1_Missense_Mutation_p.E545K	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	579					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CTGTGGCCCTCGGCCTCGGCC	0.667			T	IGH@	B-CLL								6	24					0	0	0	0	T	60688312	T	T	60688312	3	4	167	1	0	0	0	0	1	0	0	0	1365	893	31	1	882	1	BCL11A	2	60688312	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	20032332	60688312	182511061	21	31421											
REG3G	130120	broad.mit.edu	37	chr2	79255340	79255340	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attctgtctccctaggatttCtgaagtggaaagattataac	12	14	8	7	0	3	2	0	1	3	1	4	4	3	4	1	2	1	0	1	2	5	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:79255340C>G	uc002snw.2	+	6	551	c.466C>G	c.(466-468)CTG>GTG	p.L156V	REG3G_uc002snx.2_Missense_Mutation_p.L156V|REG3G_uc010ffu.2_Missense_Mutation_p.L110V	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	156	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						CCTAGGATTTCTGAAGTGGAA	0.483													12	54					0	0	0	0	G	79255340	G	G	79255340	3	3	167	1	0	0	0	0	1	0	0	0	13278	912	32	2	484	2	REG3G	2	79255340	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	18567028	79255340	163944033	22	31422											
REG1A	5967	broad.mit.edu	37	chr2	79349207	79349207	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgattaaggagagtggcActgatgacttcaatgtctgg	11	11	12	7	0	2	4	1	3	1	1	2	5	2	4	0	3	0	1	0	3	2	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:79349207A>T	uc002snz.2	+	4	380	c.277A>T	c.(277-279)ACT>TCT	p.T93S	REG1A_uc010ffx.1_3'UTR|REG1A_uc010ysd.1_Missense_Mutation_p.T93S	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	93	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						GGAGAGTGGCACTGATGACTT	0.507													17	59					0	0	0	0	T	79349207	T	T	79349207	3	4	167	1	0	0	0	0	1	0	0	0	13275	159	6	5	287	5	REG1A	2	79349207	Missense_Mutation	SNP	A	TCGA-CR-7404-01A-11D-2129-08	93867	79349207	163850166	23	31423											
IMMT	10989	broad.mit.edu	37	chr2	86398430	86398430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctgggaccgacagggtatCacctgctgcagaaataattt	11	9	12	9	1	1	1	1	0	0	1	1	3	1	2	2	3	2	4	2	3	3	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:86398430C>T	uc002sqz.3	-	5	848	c.460G>A	c.(460-462)GAT>AAT	p.D154N	IMMT_uc002sqy.3_5'UTR|IMMT_uc002srb.3_Missense_Mutation_p.D143N|IMMT_uc002sra.3_Missense_Mutation_p.D154N|IMMT_uc010ytd.1_Missense_Mutation_p.D142N|IMMT_uc010yte.1_Intron|IMMT_uc002src.1_5'UTR|IMMT_uc002srd.2_Missense_Mutation_p.D154N|IMMT_uc002sre.3_Missense_Mutation_p.D143N|IMMT_uc010ytf.1_Intron|IMMT_uc010fgs.1_Missense_Mutation_p.D151N	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	154	Mitochondrial intermembrane (Potential).			D -> E (in Ref. 4; BAG35183).		integral to mitochondrial inner membrane	protein binding			skin(1)	1						GACAGGGTATCACCTGCTGCA	0.438													3	10					0	0	0	0	T	86398430	T	T	86398430	3	4	167	1	0	0	0	0	1	0	0	0	7757	826	29	2	1860	2	IMMT	2	86398430	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	7049223	86398430	156800943	24	31424											
LIPT1	51601	broad.mit.edu	37	chr2	99779504	99779504	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacaaactaaacagtaaaTggaatattctctgtgaaaaa	20	9	5	7	0	1	1	0	1	1	0	2	2	1	2	1	1	2	1	1	1	9	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:99779504T>C	uc002szm.3	+	4	1424	c.1084T>C	c.(1084-1086)TGG>CGG	p.W362R	MRPL30_uc002szl.1_Intron|LIPT1_uc002szn.3_Missense_Mutation_p.W362R|LIPT1_uc002szo.3_Missense_Mutation_p.W362R|LIPT1_uc002szp.3_Missense_Mutation_p.W362R|LIPT1_uc002szq.3_Missense_Mutation_p.W362R|MRPL30_uc002szr.2_Intron	NM_145198	NP_660199	Q9Y234	LIPT_HUMAN	lipoyltransferase 1 precursor	362					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity				0					Lipoic Acid(DB00166)	AAACAGTAAATGGAATATTCT	0.303													8	66					0	0	0	0	C	99779504	C	C	99779504	3	2	167	1	0	0	0	0	1	0	0	0	8871	1464	51	5	1086	5	LIPT1	2	99779504	Missense_Mutation	SNP	T	TCGA-CR-7404-01A-11D-2129-08	13381074	99779504	143419869	25	31425											
MARCO	8685	broad.mit.edu	37	chr2	119750046	119750046	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtaaagggagaaaaaggtGaaagaggtaatcactattta	19	8	12	2	0	1	3	1	1	0	2	1	5	1	3	0	3	0	2	0	3	8	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:119750046G>A	uc002tln.1	+	15	1378	c.1246G>A	c.(1246-1248)GAA>AAA	p.E416K	MARCO_uc010yyf.1_Missense_Mutation_p.E338K	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	416	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						AGAAAAAGGTGAAAGAGGTAA	0.433													4	38					0	0	0	0	A	119750046	A	A	119750046	3	1	167	1	0	0	0	0	1	0	0	0	9364	1291	45	2	1304	2	MARCO	2	119750046	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	19970542	119750046	123449327	26	31426											
NEB	4703	broad.mit.edu	37	chr2	152521102	152521102	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctttcttcttttcctcttcCcagccagctttgtacagttt	4	19	4	14	0	3	0	0	0	3	0	5	0	5	0	4	0	3	3	4	0	1	8			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:152521102C>T	uc010fnx.2	-	44	5555	c.5364G>A	c.(5362-5364)TGG>TGA	p.W1788*		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1788	Nebulin 46.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTTCCTCTTCCCAGCCAGCTT	0.418													5	14					0	0	0	0	T	152521102	T	T	152521102	4	4	167	1	0	0	0	0	0	1	0	0	10356	624	22	4	20878	4	NEB	2	152521102	Nonsense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	32771056	152521102	90678271	27	31427											
SLC4A10	57282	broad.mit.edu	37	chr2	162735688	162735688	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctccaggtgctgaagcatcGaacatcttagtgggagaact	11	9	11	10	1	1	2	0	1	1	1	3	4	2	2	2	2	4	2	2	2	4	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:162735688G>A	uc002ubx.3	+	9	1180	c.996G>A	c.(994-996)TCG>TCA	p.S332S	SLC4A10_uc010fpa.1_Silent_p.S344S|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Silent_p.S302S|SLC4A10_uc010zcs.1_Silent_p.S313S	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	332	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CTGAAGCATCGAACATCTTAG	0.418													9	51					0	0	0	0	A	162735688	A	A	162735688	2	1	167	1	0	0	0	0	0	0	0	1	14715	1045	37	1		1	SLC4A10	2	162735688	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	10214586	162735688	80463685	28	31428											
XIRP2	129446	broad.mit.edu	37	chr2	168106863	168106863	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatactatcccaggatggctGataagtgaagataagagaga	17	8	11	5	0	0	5	0	2	0	3	1	7	1	6	1	2	1	1	1	2	6	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:168106863G>C	uc002udx.2	+	8	8979	c.8961G>C	c.(8959-8961)CTG>CTC	p.L2987L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.L2812L|XIRP2_uc010fpq.2_Silent_p.L2765L|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Silent_p.L333L	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2812					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAGGATGGCTGATAAGTGAAG	0.343													22	96					0	0	0	0	C	168106863	C	C	168106863	2	2	167	1	0	0	0	0	0	0	0	1	17498	1277	45	2		2	XIRP2	2	168106863	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	5371175	168106863	75092510	29	31429											
PDK1	5163	broad.mit.edu	37	chr2	173429352	173429352	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtcaccagccagaatgttCagtactttttggatcgattc	9	14	8	10	1	2	1	2	0	0	1	4	3	2	2	2	1	2	2	2	1	2	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:173429352C>G	uc002uhr.2	+	4	632	c.532C>G	c.(532-534)CAG>GAG	p.Q178E	PDK1_uc010zdz.1_Missense_Mutation_p.Q23E|PDK1_uc010zea.1_RNA|PDK1_uc002uhq.1_Missense_Mutation_p.Q198E|PDK1_uc002uhs.2_Missense_Mutation_p.Q178E|PDK1_uc010zeb.1_Missense_Mutation_p.Q198E	NM_002610	NP_002601	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase 1 precursor	178	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(3)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.12)			CCAGAATGTTCAGTACTTTTT	0.433									Autosomal_Dominant_Polycystic_Kidney_Disease				6	65					0	0	0	0	G	173429352	G	G	173429352	3	3	167	1	0	0	0	0	1	0	0	0	11729	827	29	2	546	2	PDK1	2	173429352	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	5322489	173429352	69770021	30	31430											
TTN	7273	broad.mit.edu	37	chr2	179411092	179411092	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gactttttcacagagatctaGctccttgtctcctttggtcc	6	16	7	12	0	3	1	1	0	2	1	6	3	5	1	3	1	1	1	3	1	1	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:179411092G>C	uc010zfg.1	-	291	87486	c.87262C>G	c.(87262-87264)CTA>GTA	p.L29088V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L22783V|TTN_uc010zfi.1_Missense_Mutation_p.L22716V|TTN_uc010zfj.1_Missense_Mutation_p.L22591V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30015							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAGATCTAGCTCCTTGTCT	0.438													14	74					0	0	0	0	C	179411092	C	C	179411092	3	2	167	1	0	0	0	0	1	0	0	0	16803	962	34	4	13097	4	TTN	2	179411092	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	5981740	179411092	63788281	31	31431											
TTN	7273	broad.mit.edu	37	chr2	179411461	179411461	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacggtgaagaaattgtcaGatacaatggtgtagttgcac	13	11	11	6	1	2	3	2	1	0	2	2	3	2	3	0	2	2	3	0	2	5	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:179411461G>C	uc010zfg.1	-	290	87214	c.86990C>G	c.(86989-86991)TCT>TGT	p.S28997C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S22692C|TTN_uc010zfi.1_Missense_Mutation_p.S22625C|TTN_uc010zfj.1_Missense_Mutation_p.S22500C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29924							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAATTGTCAGATACAATGGT	0.483													15	43					0	0	0	0	C	179411461	C	C	179411461	3	2	167	1	0	0	0	0	1	0	0	0	16803	942	33	2	13373	2	TTN	2	179411461	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	369	179411461	63787912	32	31432											
TTN	7273	broad.mit.edu	37	chr2	179585815	179585815	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catgaagttcgctgtcatttCggaaccatgaaactttgatt	11	14	8	8	2	1	3	1	3	0	0	3	4	1	4	1	1	2	2	1	1	3	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:179585815C>T	uc010zfg.1	-	76	19423	c.19199G>A	c.(19198-19200)CGA>CAA	p.R6400Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R3061Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7327							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTCATTTCGGAACCATGA	0.393													15	73					0	0	0	0	T	179585815	T	T	179585815	3	4	167	1	0	0	0	0	1	0	0	0	16803	884	31	1	81734	1	TTN	2	179585815	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	174354	179585815	63613558	33	31433											
SPHKAP	80309	broad.mit.edu	37	chr2	228882641	228882641	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcttcctcttcaaggatcGgcagggtacgttgggtgtca	6	14	12	9	2	4	0	2	0	2	0	6	1	5	1	1	4	1	3	1	4	2	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr2:228882641G>A	uc002vpq.2	-	7	2976	c.2929C>T	c.(2929-2931)CGA>TGA	p.R977*	SPHKAP_uc002vpp.2_Nonsense_Mutation_p.R977*|SPHKAP_uc010zlx.1_Nonsense_Mutation_p.R977*	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	977						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCAAGGATCGGCAGGGTACG	0.532													22	56					0	0	0	0	A	228882641	A	A	228882641	4	1	167	1	0	0	0	0	0	1	0	0	15114	1124	39	1	2197	1	SPHKAP	2	228882641	Nonsense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	49296826	228882641	14316732	34	31434											
ARL8B	55207	broad.mit.edu	37	chr3	5215724	5215724	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctagtgcttggaaacaagaGagatcttcctaatgccttgg	11	11	11	8	0	1	2	0	0	1	2	2	4	2	3	2	2	3	2	2	2	4	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:5215724G>C	uc003bqg.2	+	5	616	c.395G>C	c.(394-396)AGA>ACA	p.R132T	ARL8B_uc011asx.1_Missense_Mutation_p.R123T|ARL8B_uc011asy.1_Intron	NM_018184	NP_060654	Q9NVJ2	ARL8B_HUMAN	ADP-ribosylation factor-like 10C	132	GTP.				cell cycle|cell division|chromosome segregation|small GTPase mediated signal transduction	late endosome membrane|lysosomal membrane|midbody|spindle midzone	alpha-tubulin binding|beta-tubulin binding|GDP binding|GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.0717)|Epithelial(13;0.0777)		GGAAACAAGAGAGATCTTCCT	0.313													17	177					0	0	0	0	C	5215724	C	C	5215724	3	2	167	1	0	0	0	0	1	0	0	0	949	942	33	2	413	2	ARL8B	3	5215724	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08		5215724	192806706	35	31435											
NR1D2	9975	broad.mit.edu	37	chr3	24018766	24018766	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggctttgcaggaaactctCattcgtgcactaaggacctt	10	11	10	10	1	1	0	1	0	1	0	3	3	1	2	1	3	3	3	1	3	2	4	rs138945807	byFrequency	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:24018766C>T	uc003ccs.2	+	8	1915	c.1596C>T	c.(1594-1596)CTC>CTT	p.L532L	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Silent_p.L457L	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	532					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						AGGAAACTCTCATTCGTGCAC	0.368													5	32					0	0	0	0	T	24018766	T	T	24018766	2	4	167	1	0	0	0	0	0	0	0	1	10670	813	29	2		2	NR1D2	3	24018766	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	18803042	24018766	174003664	36	31436											
UQCRC1	7384	broad.mit.edu	37	chr3	48641703	48641703	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccctccacagcctgggctaGaggtgtgccctggaatgctg	6	8	13	14	0	0	1	0	0	0	1	1	2	1	2	5	3	3	2	5	3	2	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:48641703G>C	uc003cub.1	-	5	634	c.589C>G	c.(589-591)CTA>GTA	p.L197V	UQCRC1_uc003cua.1_Missense_Mutation_p.L82V|UQCRC1_uc003cuc.1_Missense_Mutation_p.L197V|UQCRC1_uc003cud.1_Missense_Mutation_p.L197V	NM_003365	NP_003356	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	197					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	GCCTGGGCTAGAGGTGTGCCC	0.572													5	93					0	0	0	0	C	48641703	C	C	48641703	3	2	167	1	0	0	0	0	1	0	0	0	17087	933	33	2	889	2	UQCRC1	3	48641703	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	24622937	48641703	149380727	37	31437											
QTRTD1	79691	broad.mit.edu	37	chr3	113798870	113798870	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggggatgtgccctgactttCagttttgattaccagccgaa	8	12	11	10	2	1	2	1	2	0	0	1	4	1	3	3	2	3	1	3	2	2	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:113798870C>A	uc003eay.2	+	8	1094	c.864C>A	c.(862-864)TTC>TTA	p.F288L	QTRTD1_uc003eaz.2_Missense_Mutation_p.F300L|QTRTD1_uc011biq.1_Missense_Mutation_p.F165L|QTRTD1_uc011bir.1_Missense_Mutation_p.F182L	NM_024638	NP_078914	Q9H974	QTRD1_HUMAN	queuine tRNA-ribosyltransferase domain	288					queuosine biosynthetic process	mitochondrion	metal ion binding|queuine tRNA-ribosyltransferase activity			central_nervous_system(1)|skin(1)	2						CCCTGACTTTCAGTTTTGATT	0.413													32	194					6.70999e-13	7.48571e-13	1	0	A	113798870	A	A	113798870	3	1	167	1	0	0	0	0	1	0	0	0	12951	825	29	2	886	2	QTRTD1	3	113798870	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	65157167	113798870	84223560	38	31438											
NEK11	79858	broad.mit.edu	37	chr3	131068603	131068603	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgatgggaaaagaacctactCtccagaaccatctctaggca	14	7	8	12	1	2	2	0	0	2	2	4	4	2	3	3	2	3	1	3	2	6	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:131068603C>T	uc003eny.2	+	18	2247	c.1921C>T	c.(1921-1923)CTC>TTC	p.L641F	uc003eoc.1_Intron|NEK11_uc003eoa.2_3'UTR|NEK11_uc003enz.2_Missense_Mutation_p.L459F|NEK11_uc010htn.2_RNA|NEK11_uc011blk.1_Missense_Mutation_p.L457F|NEK11_uc011bll.1_Missense_Mutation_p.L536F	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1	641					cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						AGAACCTACTCTCCAGAACCA	0.403													5	78					0	0	0	0	T	131068603	T	T	131068603	3	4	167	1	0	0	0	0	1	0	0	0	10377	913	32	2	2001	2	NEK11	3	131068603	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	17269733	131068603	66953827	39	31439											
ZBTB38	253461	broad.mit.edu	37	chr3	141163374	141163374	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctacagtggctctgcaccctCggtcattgtacacagcagcc	8	9	9	15	1	2	0	1	0	1	0	3	0	2	0	2	2	5	4	2	2	2	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:141163374C>T	uc003etw.2	+	8	3126	c.2144C>T	c.(2143-2145)TCG>TTG	p.S715L	ZBTB38_uc010hun.2_Missense_Mutation_p.S712L|ZBTB38_uc010huo.2_Missense_Mutation_p.S715L|ZBTB38_uc003ety.2_Missense_Mutation_p.S715L|ZBTB38_uc010hup.2_Missense_Mutation_p.S716L	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	715					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TCTGCACCCTCGGTCATTGTA	0.522													19	128					0	0	0	0	T	141163374	T	T	141163374	3	4	167	1	0	0	0	0	1	0	0	0	17606	893	31	1	2146	1	ZBTB38	3	141163374	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	10094771	141163374	56859056	40	31440											
SI	6476	broad.mit.edu	37	chr3	164754187	164754187	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagacttacctttagtttcTccatcatcccagaaaaagtc	12	13	4	12	0	3	2	2	0	1	2	6	2	4	2	3	0	1	1	3	0	4	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:164754187T>C	uc003fei.2	-	22	2567	c.2505A>G	c.(2503-2505)GGA>GGG	p.G835G		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	835	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTTTAGTTTCTCCATCATCCC	0.343										HNSCC(35;0.089)			4	74					0	0	0	0	C	164754187	C	C	164754187	2	2	167	1	0	0	0	0	0	0	0	1	14362	1538	54	5		5	SI	3	164754187	Silent	SNP	T	TCGA-CR-7404-01A-11D-2129-08	23590813	164754187	33268243	41	31441											
PLD1	5337	broad.mit.edu	37	chr3	171404477	171404477	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acttcacaaattacttaccaGcatgaggtctagtgagtcct	12	12	7	10	0	2	2	1	2	1	0	3	2	3	2	2	1	3	1	2	1	4	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:171404477G>A	uc003fhs.2	-	16	1981	c.1865C>T	c.(1864-1866)GCT>GTT	p.A622V	PLD1_uc003fht.2_Intron	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	622	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TTACTTACCAGCATGAGGTCT	0.443													17	225					0	0	0	0	A	171404477	A	A	171404477	3	1	167	1	0	0	0	0	1	0	0	0	12100	971	34	4	1407	4	PLD1	3	171404477	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	6650290	171404477	26617953	42	31442											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	66					0	0	0	0	A	178936091	A	A	178936091	3	1	167	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	7531614	178936091	19086339	43	31443											
ATP13A4	84239	broad.mit.edu	37	chr3	193175211	193175211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taactaccatggcatgtgccGgcactcccttgatgtggaaa	10	10	10	11	1	0	1	0	1	0	0	1	2	1	2	3	3	3	2	3	3	3	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:193175211G>A	uc003ftd.2	-	15	1826	c.1718C>T	c.(1717-1719)CCG>CTG	p.P573L	ATP13A4_uc003fte.1_Missense_Mutation_p.P573L|ATP13A4_uc011bsr.1_Missense_Mutation_p.P44L|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	573	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GGCATGTGCCGGCACTCCCTT	0.458													13	185					0	0	0	0	A	193175211	A	A	193175211	3	1	167	1	0	0	0	0	1	0	0	0	1128	1116	39	1	1936	1	ATP13A4	3	193175211	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	14239120	193175211	4847219	44	31444											
TNK2	10188	broad.mit.edu	37	chr3	195608990	195608990	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgaggtagtgctcgcatCagcccaaagtccccgatctt	8	11	9	13	2	3	1	1	1	2	0	5	2	4	1	3	1	2	3	3	1	2	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr3:195608990C>T	uc003fvu.1	-	6	1362	c.819G>A	c.(817-819)CTG>CTA	p.L273L	TNK2_uc003fvs.1_Silent_p.L305L|TNK2_uc003fvt.1_Silent_p.L336L|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Silent_p.L103L|TNK2_uc010hzx.1_Intron	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	273	Protein kinase.				positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GTGCTCGCATCAGCCCAAAGT	0.592													14	110					0	0	0	0	T	195608990	T	T	195608990	2	4	167	1	0	0	0	0	0	0	0	1	16384	813	29	2		2	TNK2	3	195608990	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	2433779	195608990	2413440	45	31445											
ALB	213	broad.mit.edu	37	chr4	74274401	74274401	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgtgcaaaacaagaacctGagagaaatgaatgcttcttg	15	9	10	7	0	1	4	0	2	1	2	1	5	1	4	1	0	4	3	1	0	6	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr4:74274401G>C	uc003hgs.3	+	4	434	c.361G>C	c.(361-363)GAG>CAG	p.E121Q	ALB_uc003hgw.3_Intron|ALB_uc011cbe.1_Intron|ALB_uc003hgt.3_Missense_Mutation_p.E121Q|ALB_uc010iii.2_Intron|ALB_uc003hgu.3_Intron|ALB_uc003hgv.3_Intron|ALB_uc011cbf.1_Missense_Mutation_p.E11Q|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'Flank	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	121	Albumin 1.		E -> G.		bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	ACAAGAACCTGAGAGAAATGA	0.433													7	44					0	0	0	0	C	74274401	C	C	74274401	3	2	167	1	0	0	0	0	1	0	0	0	486	1291	45	2	375	2	ALB	4	74274401	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08		74274401	116879875	46	31446											
GPRIN3	285513	broad.mit.edu	37	chr4	90171030	90171030	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaacacaccaggagaagacaTatctggttgggtggtctcat	12	9	12	8	0	2	2	1	0	2	2	3	4	2	2	1	4	1	1	1	4	3	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr4:90171030T>C	uc003hsm.1	-	2	751	c.232A>G	c.(232-234)ATG>GTG	p.M78V		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	78										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GGAGAAGACATATCTGGTTGG	0.582													26	63					0	0	0	0	C	90171030	C	C	90171030	3	2	167	1	0	0	0	0	1	0	0	0	6770	1406	49	5	2102	5	GPRIN3	4	90171030	Missense_Mutation	SNP	T	TCGA-CR-7404-01A-11D-2129-08	15896629	90171030	100983246	47	31447											
ZNF827	152485	broad.mit.edu	37	chr4	146824152	146824152	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtctcgcaggacctcactgtCcagtgccaccagctccaacg	8	7	9	17	2	2	0	1	0	1	0	5	1	4	1	5	1	3	2	5	1	1	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr4:146824152C>T	uc003ikn.2	-	2	307	c.259G>A	c.(259-261)GAC>AAC	p.D87N	ZNF827_uc003ikm.2_Missense_Mutation_p.D87N|ZNF827_uc010iox.2_Intron	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					ACCTCACTGTCCAGTGCCACC	0.602													8	27					0	0	0	0	T	146824152	T	T	146824152	3	4	167	1	0	0	0	0	1	0	0	0	18247	855	30	2	3022	2	ZNF827	4	146824152	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	56653122	146824152	44330124	48	31448											
NIPBL	25836	broad.mit.edu	37	chr5	37064919	37064929	+	Frame_Shift_Del	DEL	TGCTAATAAGC	-	-																															aaaaaaattgctctaacgagTgctaataagctgactaataa																										TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr5:37064919_37064929delTGCTAATAAGC	uc003jkl.3	+	47	8839_8849	c.8340_8350delTGCTAATAAGC	c.(8338-8352)AGTGCTAATAAGCTGfs	p.S2780fs	NIPBL_uc003jkk.3_3'UTR|NIPBL_uc003jkn.2_3'UTR	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2780_2784					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTCTAACGAGTGCTAATAAGCTGACTAATAA	0.427													---	---	---								-	37064929	-	-	37064919	7	5	167	1	0	1	0	1	0	0	0	0	10482	1693	59	0	8567	0	NIPBL	5	37064919	Frame_Shift_Del	DEL	TGCTAATAAGC	TCGA-CR-7404-01A-11D-2129-08		37064919	143850341	49	31449											
PRKAA1	5562	broad.mit.edu	37	chr5	40798216	40798216	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtgtcacccagaatgtagtGgccgatcttcacccgcccgt	7	9	10	15	4	3	1	2	0	1	1	3	2	3	1	4	1	0	1	4	1	2	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr5:40798216G>T	uc003jmc.2	-	1	82	c.76C>A	c.(76-78)CAC>AAC	p.H26N	PRKAA1_uc003jmb.2_Missense_Mutation_p.H26N	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	26					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	AGAATGTAGTGGCCGATCTTC	0.577													5	32					2.0095e-06	2.21619e-06	1	0	T	40798216	T	T	40798216	3	4	167	1	0	0	0	0	1	0	0	0	12555	1348	47	4	1688	4	PRKAA1	5	40798216	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	3733297	40798216	140117044	50	31450											
C5orf56	441108	broad.mit.edu	37	chr5	131822224	131822224	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccactgacctgtggggtcTcctgccagacctggaccagc	6	8	11	16	0	1	2	0	1	1	1	3	3	2	3	6	3	2	0	6	3	0	0	rs9282761	byFrequency	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr5:131822224T>C	uc010jds.1	+	4	560	c.385T>C	c.(385-387)TCC>CCC	p.S129P	IRF1_uc003kxd.2_Intron|IRF1_uc003kxa.2_Intron|IRF1_uc003kxb.2_Intron|IRF1_uc010jdt.1_Intron			Q8N8D9	CE056_HUMAN	Homo sapiens full length insert cDNA clone ZA99C08.	Error:Variant_position_missing_in_Q8N8D9_after_alignment											0						CTGTGGGGTCTCCTGCCAGAC	0.612													3	17					0	0	0	0	C	131822224	C	C	131822224	3	2	167	1	0	0	0	0	1	0	0	0	2322	1566	54	5		5	C5orf56	5	131822224	Missense_Mutation	SNP	T	TCGA-CR-7404-01A-11D-2129-08	91024008	131822224	49093036	51	31451											
PCDHGC3	5098	broad.mit.edu	37	chr5	140855927	140855927	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gattctttgaggtgaaccggGagaccggagagatgtttgtg	9	11	16	5	2	1	4	0	2	1	2	1	8	1	5	2	3	1	1	2	3	1	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr5:140855927G>C	uc003lkv.1	+	1	359	c.244G>C	c.(244-246)GAG>CAG	p.E82Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Missense_Mutation_p.E82Q|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	82	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGAACCGGGAGACCGGAGA	0.572													7	120					0	0	0	0	C	140855927	C	C	140855927	3	2	167	1	0	0	0	0	1	0	0	0	11623	1175	41	2	246	2	PCDHGC3	5	140855927	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	9033703	140855927	40059333	52	31452											
LY6G5C	80741	broad.mit.edu	37	chr6	31646945	31646945	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagatgtcagatcccagaagGcaccctaactccttggtctc	10	9	8	14	0	2	3	1	0	1	3	5	3	4	3	3	2	1	1	3	2	2	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:31646945G>A	uc003nvu.1	-	2	213	c.213C>T	c.(211-213)TGC>TGT	p.C71C	LY6G5C_uc003nvw.1_RNA|LY6G5C_uc010jtb.1_RNA	NM_025262	NP_079538	Q5SRR4	LY65C_HUMAN	lymphocyte antigen 6 complex G5C	74	UPAR/Ly6.					extracellular region					0						ATCCCAGAAGGCACCCTAACT	0.542													35	136					0	0	0	0	A	31646945	A	A	31646945	2	1	167	1	0	0	0	0	0	0	0	1	9144	1195	42	4		4	LY6G5C	6	31646945	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08		31646945	139468122	53	31453											
BAT5	7920	broad.mit.edu	37	chr6	31655463	31655463	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtgttctgcctggtaggagCggaggacagacagacaccag	10	6	15	10	2	1	2	0	0	1	2	1	5	1	5	2	4	2	2	2	4	1	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:31655463C>T	uc003nvy.1	-	18	1532	c.1502G>A	c.(1501-1503)CGC>CAC	p.R501H	BAT5_uc003nvx.1_Missense_Mutation_p.R282H|BAT5_uc011dny.1_Missense_Mutation_p.R468H|BAT5_uc003nvz.1_Missense_Mutation_p.R282H|BAT5_uc011dnz.1_Missense_Mutation_p.R282H	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	501						integral to membrane	hydrolase activity|protein binding				0						CTGGTAGGAGCGGAGGACAGA	0.597													8	43					0	0	0	0	T	31655463	T	T	31655463	3	4	167	1	0	0	0	0	1	0	0	0	1326	768	27	1	186	1	BAT5	6	31655463	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	8518	31655463	139459604	54	31454											
TNXB	7148	broad.mit.edu	37	chr6	32016196	32016196	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccattctggagtccaaagAgcaggaacttgtacttgcgg	10	10	11	10	1	1	1	0	0	1	1	3	3	3	3	2	3	4	2	2	3	3	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:32016196A>T	uc003nzl.2	-	29	10185	c.9983T>A	c.(9982-9984)CTC>CAC	p.L3328H	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3375	Fibronectin type-III 25.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GAGTCCAAAGAGCAGGAACTT	0.701													6	31					0	0	0	0	T	32016196	T	T	32016196	3	4	167	1	0	0	0	0	1	0	0	0	16412	304	11	5	4794	5	TNXB	6	32016196	Missense_Mutation	SNP	A	TCGA-CR-7404-01A-11D-2129-08	360733	32016196	139098871	55	31455											
TNXB	7148	broad.mit.edu	37	chr6	32017777	32017777	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccatcattcactcacccGtcaccccaatggcagacaca	11	7	4	19	1	4	1	4	0	0	1	5	1	5	1	4	1	0	1	4	1	1	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:32017777G>A	uc003nzl.2	-	27	9633	c.9431C>T	c.(9430-9432)ACG>ATG	p.T3144M		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3191					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCACTCACCCGTCACCCCAAT	0.602													8	83					0	0	0	0	A	32017777	A	A	32017777	3	1	167	1	0	0	0	0	1	0	0	0	16412	1145	40	1	5354	1	TNXB	6	32017777	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	1581	32017777	139097290	56	31456											
LAMA4	3910	broad.mit.edu	37	chr6	112510392	112510392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttacactgtcacatgggcctCccccgcagttgcacactgtg	7	10	9	15	1	1	0	1	0	0	0	2	0	2	0	3	1	2	3	3	1	1	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:112510392C>T	uc003pvu.2	-	7	1043	c.734G>A	c.(733-735)GGA>GAA	p.G245E	LAMA4_uc003pvv.2_Missense_Mutation_p.G245E|LAMA4_uc003pvt.2_Missense_Mutation_p.G245E	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	245	Laminin EGF-like 4; truncated.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		ACATGGGCCTCCCCCGCAGTT	0.428													5	28					0	0	0	0	T	112510392	T	T	112510392	3	4	167	1	0	0	0	0	1	0	0	0	8648	855	30	2	4869	2	LAMA4	6	112510392	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	80492615	112510392	58604675	57	31457											
RGS17	26575	broad.mit.edu	37	chr6	153365099	153365099	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gttgggcctctggtttccagGagcttgagacacggcaggtg	6	10	16	9	1	1	1	0	1	1	1	2	3	2	2	2	5	1	4	2	5	0	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr6:153365099G>A	uc003qpm.2	-	2	211	c.55C>T	c.(55-57)CCT>TCT	p.P19S		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	19					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		TGGTTTCCAGGAGCTTGAGAC	0.493									Lung_Cancer_Familial_Clustering_of				7	149					0	0	0	0	A	153365099	A	A	153365099	3	1	167	1	0	0	0	0	1	0	0	0	13364	1174	41	2	593	2	RGS17	6	153365099	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	40854707	153365099	17749968	58	31458											
HOXA1	3198	broad.mit.edu	37	chr7	27135348	27135348	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtggtggtggggcgaacCgatctgcacccccctgccca	5	7	15	14	2	1	0	0	0	1	0	1	2	1	0	5	5	3	1	5	5	1	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr7:27135348C>T	uc003sye.2	-	1	278	c.184G>A	c.(184-186)GGT>AGT	p.G62S	HOXA1_uc003syd.2_Missense_Mutation_p.G62S|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	62						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						tggGGCGAACCGATCTGCACC	0.522											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	32					0	0	0	0	T	27135348	T	T	27135348	3	4	167	1	0	0	0	0	1	0	0	0	7327	652	23	1	831	1	HOXA1	7	27135348	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08		27135348	132003315	59	31459											
HECW1	23072	broad.mit.edu	37	chr7	43519316	43519316	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcaccgacagcacctccaGaggctccgaagttacagcgc	11	5	9	16	3	1	1	1	0	0	1	3	3	3	1	4	1	3	3	4	1	2	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr7:43519316G>A	uc003tid.1	+	17	3812	c.3207G>A	c.(3205-3207)CAG>CAA	p.Q1069Q	HECW1_uc011kbi.1_Silent_p.Q1035Q	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1069					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGCACCTCCAGAGGCTCCGAA	0.557													7	120					0	0	0	0	A	43519316	A	A	43519316	2	1	167	1	0	0	0	0	0	0	0	1	7081	933	33	2		2	HECW1	7	43519316	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	16383968	43519316	115619347	60	31460											
MGC26647	219557	broad.mit.edu	37	chr7	88423630	88423630	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tactttatgatttgttctggGaggagtaggtcaggtgcaac	9	14	13	5	0	2	1	1	1	1	0	2	3	2	3	0	4	3	3	0	4	4	6			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr7:88423630G>C	uc003ujv.2	-	2	809	c.627C>G	c.(625-627)CTC>CTG	p.L209L	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	209											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			TTTGTTCTGGGAGGAGTAGGT	0.413													13	73					0	0	0	0	C	88423630	C	C	88423630	2	2	167	1	0	0	0	0	0	0	0	1	9603	1161	41	2		2	MGC26647	7	88423630	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	44904314	88423630	70715033	61	31461											
SLC26A3	1811	broad.mit.edu	37	chr7	107432371	107432371	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggggaatgtcgaccagcaGagcaaatgctaaacctgtaa	14	7	12	8	1	0	1	0	0	0	1	1	3	0	2	2	2	4	4	2	2	5	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr7:107432371G>C	uc003ver.2	-	4	497	c.286C>G	c.(286-288)CTG>GTG	p.L96V	SLC26A3_uc003ves.2_Missense_Mutation_p.L61V	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	96	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						TCGACCAGCAGAGCAAATGCT	0.438													3	39					0	0	0	0	C	107432371	C	C	107432371	3	2	167	1	0	0	0	0	1	0	0	0	14582	933	33	2	2080	2	SLC26A3	7	107432371	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	19008741	107432371	51706292	62	31462											
TRPV6	55503	broad.mit.edu	37	chr7	142569516	142569516	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acccctgttgattatcccacGcaggtctctcctcagggtcc	6	11	8	16	1	2	1	1	1	1	0	6	1	5	1	5	2	0	2	5	2	1	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr7:142569516G>A	uc003wbx.1	-	15	2338	c.2122C>T	c.(2122-2124)CGT>TGT	p.R708C	TRPV6_uc003wbw.1_Missense_Mutation_p.R494C|TRPV6_uc010lou.1_Missense_Mutation_p.R579C	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	708	Interaction with calmodulin.|Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					ATTATCCCACGCAGGTCTCTC	0.567													8	62					0	0	0	0	A	142569516	A	A	142569516	3	1	167	1	0	0	0	0	1	0	0	0	16667	1087	38	1	59	1	TRPV6	7	142569516	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	35137145	142569516	16569147	63	31463											
CHD7	55636	broad.mit.edu	37	chr8	61764696	61764696	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcagctataaaaggcaacaGatgaggcaagaggccctaat	16	5	11	9	1	0	3	0	1	0	2	0	3	0	3	1	3	2	4	1	3	6	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr8:61764696G>A	uc003xue.2	+	29	6261	c.5784G>A	c.(5782-5784)CAG>CAA	p.Q1928Q		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1928					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AAAGGCAACAGATGAGGCAAG	0.527													7	41					0	0	0	0	A	61764696	A	A	61764696	2	1	167	1	0	0	0	0	0	0	0	1	3345	933	33	2		2	CHD7	8	61764696	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08		61764696	84599326	64	31464											
CHMP4C	92421	broad.mit.edu	37	chr8	82670413	82670413	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aacttgaagaattggaacagGaggaattaaataagaagatg	20	8	11	2	0	0	4	0	1	0	3	0	7	0	7	0	3	2	0	0	3	9	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr8:82670413G>A	uc003ycl.2	+	4	694	c.520G>A	c.(520-522)GAG>AAG	p.E174K		NM_152284	NP_689497	Q96CF2	CHM4C_HUMAN	chromatin modifying protein 4C	174	Potential.|Intramolecular interaction with N- terminus (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			ovary(2)	2						ATTGGAACAGGAGGAATTAAA	0.433													4	52					0	0	0	0	A	82670413	A	A	82670413	3	1	167	1	0	0	0	0	1	0	0	0	3373	1175	41	2	534	2	CHMP4C	8	82670413	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	20905717	82670413	63693609	65	31465											
TRPS1	7227	broad.mit.edu	37	chr8	116426463	116426463	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacacattttgttgaaagttCatcttgagtacttctatcaa	12	16	5	8	0	4	2	2	2	2	0	4	2	4	2	0	0	1	3	0	0	4	8			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr8:116426463C>T	uc003ynz.2	-	6	4093	c.3634G>A	c.(3634-3636)GAA>AAA	p.E1212K	TRPS1_uc011lhy.1_Missense_Mutation_p.E1216K|TRPS1_uc003yny.2_Missense_Mutation_p.E1225K|TRPS1_uc010mcy.2_Missense_Mutation_p.E1212K	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	1212	Transcriptional repressor domain (By similarity).				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GTTGAAAGTTCATCTTGAGTA	0.418									Langer-Giedion_syndrome				12	62					0	0	0	0	T	116426463	T	T	116426463	3	4	167	1	0	0	0	0	1	0	0	0	16660	835	29	2	215	2	TRPS1	8	116426463	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	33756050	116426463	29937559	66	31466											
MAPK15	225689	broad.mit.edu	37	chr8	144803822	144803823	+	Frame_Shift_Ins	INS	-	C	C																															cccctggggcgaaggaagcgINSccccccttgacactctcgct																										TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr8:144803822_144803823insC	uc003yzj.2	+	12	1349_1350	c.1308_1309insC	c.(1306-1311)GCGCCCfs	p.A436fs		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	436_437					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CGAAGGAAGCGCCCCCCTTGAC	0.644													---	---	---								C	144803823	C	C	144803822	7	5	167	1	0	1	1	0	0	0	0	0	9330	1074	38	0	1354	0	MAPK15	8	144803822	Frame_Shift_Ins	INS	-	TCGA-CR-7404-01A-11D-2129-08	28377359	144803822	1560200	67	31467											
TTC39B	158219	broad.mit.edu	37	chr9	15214144	15214144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caaagtaaattaccaggggcGaagcaattctaaggcgtctg	14	8	11	8	2	2	0	0	0	2	0	2	1	2	0	1	3	2	2	1	3	7	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr9:15214144G>A	uc003zlr.1	-	4	398	c.277C>T	c.(277-279)CGC>TGC	p.R93C	TTC39B_uc003zlq.1_Missense_Mutation_p.R62C|TTC39B_uc011lmp.1_5'UTR|TTC39B_uc010mie.1_Missense_Mutation_p.R93C|TTC39B_uc011lmq.1_Missense_Mutation_p.R93C|TTC39B_uc011lmr.1_Intron|TTC39B_uc010mif.1_Missense_Mutation_p.R93C|TTC39B_uc003zls.1_5'UTR|TTC39B_uc010mig.1_Missense_Mutation_p.R62C|TTC39B_uc011lms.1_RNA	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	93							binding			ovary(1)	1						TACCAGGGGCGAAGCAATTCT	0.368													17	43					0	0	0	0	A	15214144	A	A	15214144	3	1	167	1	0	0	0	0	1	0	0	0	16776	1058	37	1	1662	1	TTC39B	9	15214144	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08		15214144	125999287	68	31468											
CEP78	84131	broad.mit.edu	37	chr9	80856706	80856706	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagcagatcacatggccaaGatcttaaaggtaactttatg	14	10	10	7	0	2	2	1	0	1	2	2	3	2	3	1	3	2	2	1	3	5	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr9:80856706G>A	uc004akx.2	+	4	870	c.594G>A	c.(592-594)AAG>AAA	p.K198K	CEP78_uc004aky.3_Silent_p.K198K|CEP78_uc010mpp.2_Silent_p.K198K|CEP78_uc011lsp.1_Silent_p.K111K	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	198					G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1						ACATGGCCAAGATCTTAAAGG	0.343													13	38					0	0	0	0	A	80856706	A	A	80856706	2	1	167	1	0	0	0	0	0	0	0	1	3277	933	33	2		2	CEP78	9	80856706	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	65642562	80856706	60356725	69	31469											
GTPBP4	23560	broad.mit.edu	37	chr10	1042133	1042133	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgcggccctgggacggatGtgcacagtgatcaagaggca	9	6	16	10	3	1	2	1	1	0	1	1	4	1	4	1	4	2	2	1	4	1	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:1042133G>A	uc001ift.2	+	4	482	c.411G>A	c.(409-411)ATG>ATA	p.M137I	GTPBP4_uc010qac.1_Translation_Start_Site|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Missense_Mutation_p.M21I|GTPBP4_uc010qae.1_Missense_Mutation_p.M90I	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	137					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		TGGGACGGATGTGCACAGTGA	0.512													3	17					0	0	0	0	A	1042133	A	A	1042133	3	1	167	1	0	0	0	0	1	0	0	0	6921	1377	48	4	425	4	GTPBP4	10	1042133	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08		1042133	134492614	70	31470											
EPC1	80314	broad.mit.edu	37	chr10	32582604	32582604	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttctttttcagtttattCacaaatacttcatcttcaga	11	20	2	8	0	6	1	4	0	2	1	6	1	6	1	0	0	1	1	0	0	3	10			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:32582604C>T	uc001iwg.1	-	3	645	c.375G>A	c.(373-375)GTG>GTA	p.V125V	EPC1_uc001iwi.3_Silent_p.V75V|EPC1_uc009xlt.2_Silent_p.V75V|EPC1_uc001iwh.1_Silent_p.V125V	NM_025209	NP_079485	Q9H2F5	EPC1_HUMAN	enhancer of polycomb 1	125					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)				TCAGTTTATTCACAAATACTT	0.383													8	36					0	0	0	0	T	32582604	T	T	32582604	2	4	167	1	0	0	0	0	0	0	0	1	5184	813	29	2		2	EPC1	10	32582604	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	31540471	32582604	102952143	71	31471											
ANKRD30A	91074	broad.mit.edu	37	chr10	37421251	37421251	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgataaaaaatgcaaatgcGaatgcagttaataagtataa	20	10	7	4	1	0	1	0	1	0	0	0	2	0	1	0	0	3	4	0	0	9	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:37421251G>C	uc001iza.1	+	4	525	c.426G>C	c.(424-426)GCG>GCC	p.A142A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	198	ANK 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ATGCAAATGCGAATGCAGTTA	0.299													6	76					0	0	0	0	C	37421251	C	C	37421251	2	2	167	1	0	0	0	0	0	0	0	1	658	1045	37	3		3	ANKRD30A	10	37421251	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	4838647	37421251	98113496	72	31472											
AIFM2	84883	broad.mit.edu	37	chr10	71874076	71874076	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccatggacaggaggaacGtcagtgcacctgcaagcaga	12	5	12	12	1	1	1	1	0	0	1	2	4	2	4	3	3	4	3	3	3	2	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:71874076G>A	uc010qjg.1	-	8	993	c.980C>T	c.(979-981)ACG>ATG	p.T327M	AIFM2_uc001jqp.1_Missense_Mutation_p.T327M	NM_032797	NP_116186	Q9BRQ8	AIFM2_HUMAN	apoptosis-inducing factor (AIF)-like	327					apoptotic mitochondrial changes|chromosome condensation|induction of apoptosis	cytosol|integral to membrane|mitochondrial outer membrane	DNA binding|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding			central_nervous_system(1)	1						CAGGAGGAACGTCAGTGCACC	0.592													12	39					0	0	0	0	A	71874076	A	A	71874076	3	1	167	1	0	0	0	0	1	0	0	0	427	1145	40	1	145	1	AIFM2	10	71874076	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	34452825	71874076	63660671	73	31473											
ARHGAP19	84986	broad.mit.edu	37	chr10	99025873	99025873	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcagatcacaaaactgcaGatggcatcactgaaaaacac	17	7	7	10	0	2	3	2	1	0	2	2	3	2	3	0	1	4	3	0	1	4	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:99025873G>C	uc001knb.2	-	2	95	c.66C>G	c.(64-66)ATC>ATG	p.I22M	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Missense_Mutation_p.I13M|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Missense_Mutation_p.I22M|ARHGAP19_uc009xvk.2_Intron	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	22					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)		CAAAACTGCAGATGGCATCAC	0.408													12	57					0	0	0	0	C	99025873	C	C	99025873	3	2	167	1	0	0	0	0	1	0	0	0	869	932	33	2	1462	2	ARHGAP19	10	99025873	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	27151797	99025873	36508874	74	31474											
NOLC1	9221	broad.mit.edu	37	chr10	103912186	103912186	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggatggcggacgccggcattCgccgcgtggttcccagcgac	5	6	16	14	7	0	0	0	0	0	0	2	3	1	2	3	5	1	2	3	5	0	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr10:103912186C>T	uc001kuo.2	+	1	254	c.19C>T	c.(19-21)CGC>TGC	p.R7C	NOLC1_uc001kup.2_Missense_Mutation_p.R7C|NOLC1_uc001kuq.2_Missense_Mutation_p.R7C|NOLC1_uc009xxb.1_5'UTR|NOLC1_uc001kur.2_5'UTR	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	7					mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		CGCCGGCATTCGCCGCGTGGT	0.622													12	72					0	0	0	0	T	103912186	T	T	103912186	3	4	167	1	0	0	0	0	1	0	0	0	10583	884	31	1	21	1	NOLC1	10	103912186	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	4886313	103912186	31622561	75	31475											
C11orf35	256329	broad.mit.edu	37	chr11	557988	557988	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgcagctcggcctccatctCctggagcgtgcgggtggtct	3	10	14	14	3	2	0	0	0	2	0	5	1	3	1	3	4	4	2	3	4	0	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:557988C>G	uc001lpx.2	-	5	514	c.451G>C	c.(451-453)GAG>CAG	p.E151Q	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank|RASSF7_uc001lqb.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	151	Potential.									pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCTCCATCTCCTGGAGCGTG	0.657													11	25					0	0	0	0	G	557988	G	G	557988	3	3	167	1	0	0	0	0	1	0	0	0	1644	864	30	2	1493	2	C11orf35	11	557988	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08		557988	134448528	76	31476											
C11orf35	256329	broad.mit.edu	37	chr11	558188	558188	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcgctccttctgttccttCaactcctggatcagcttctg	4	15	7	15	1	4	0	2	0	2	0	8	1	7	1	3	1	2	4	3	1	1	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:558188C>G	uc001lpx.2	-	4	435	c.372G>C	c.(370-372)TTG>TTC	p.L124F	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank|RASSF7_uc001lqb.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	124	Potential.									pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCTGTTCCTTCAACTCCTGGA	0.652													7	26					0	0	0	0	G	558188	G	G	558188	3	3	167	1	0	0	0	0	1	0	0	0	1644	825	29	2	1576	2	C11orf35	11	558188	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	200	558188	134448328	77	31477											
OR51A2	401667	broad.mit.edu	37	chr11	4976057	4976057	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcactctaatctgtttagttTttacacaataaacaattggt	13	17	4	7	0	3	0	1	0	2	0	3	0	3	0	0	1	2	2	0	1	7	8			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:4976057T>G	uc010qyt.1	-	1	887	c.887A>C	c.(886-888)AAA>ACA	p.K296T		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTTTAGTTTTTACACAATA	0.388													6	73					0	0	0	0	G	4976057	G	G	4976057	3	3	167	1	0	0	0	0	1	0	0	0	11140	1841	64	5	56	5	OR51A2	11	4976057	Missense_Mutation	SNP	T	TCGA-CR-7404-01A-11D-2129-08	4417869	4976057	130030459	78	31478											
OR51A2	401667	broad.mit.edu	37	chr11	4976440	4976440	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtttttcttgcaatatctCaagcttcttaaagtgaaagg	11	16	8	6	0	3	1	1	1	3	0	4	1	3	1	0	2	2	3	0	2	6	6			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:4976440C>G	uc010qyt.1	-	1	504	c.504G>C	c.(502-504)TTG>TTC	p.L168F		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCAATATCTCAAGCTTCTTA	0.423													41	211					0	0	0	0	G	4976440	G	G	4976440	3	3	167	1	0	0	0	0	1	0	0	0	11140	825	29	2	439	2	OR51A2	11	4976440	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	383	4976440	130030076	79	31479											
OR4D6	219983	broad.mit.edu	37	chr11	59224497	59224497	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaacttacacgttcccgaGagctggagtttttcttgttt	7	16	10	8	2	1	1	0	0	1	1	2	4	2	3	1	2	3	4	1	2	2	6			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:59224497G>A	uc010rku.1	+	1	64	c.64G>A	c.(64-66)GAG>AAG	p.E22K		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACGTTCCCGAGAGCTGGAGTT	0.468													6	112					0	0	0	0	A	59224497	A	A	59224497	3	1	167	1	0	0	0	0	1	0	0	0	11112	943	33	2	66	2	OR4D6	11	59224497	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	54248057	59224497	75782019	80	31480											
TPCN2	219931	broad.mit.edu	37	chr11	68822767	68822767	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agccgccctgcggcctgaccGagagtgtcgaggtgctctgc	5	7	15	14	4	1	2	0	1	1	1	2	4	1	2	4	2	4	1	4	2	0	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:68822767G>A	uc001oos.2	+	4	492	c.376G>A	c.(376-378)GAG>AAG	p.E126K	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Intron|TPCN2_uc010rqg.1_Missense_Mutation_p.E126K	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	126	Extracellular (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CGGCCTGACCGAGAGTGTCGA	0.672													15	59					0	0	0	0	A	68822767	A	A	68822767	3	1	167	1	0	0	0	0	1	0	0	0	16463	1059	37	1	390	1	TPCN2	11	68822767	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	9598270	68822767	66183749	81	31481											
SHANK2	22941	broad.mit.edu	37	chr11	70331427	70331427	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgcggacttaccttggagcGaggctggcggacttggctcc	5	8	15	13	4	0	0	0	0	0	0	1	4	1	3	3	6	2	2	3	6	1	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:70331427G>A	uc001oqc.2	-	21	5049	c.4971C>T	c.(4969-4971)CTC>CTT	p.L1657L	SHANK2_uc010rqn.1_Silent_p.L1069L|SHANK2_uc001opz.2_Silent_p.L1062L|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1278					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACCTTGGAGCGAGGCTGGCGG	0.577													10	47					0	0	0	0	A	70331427	A	A	70331427	2	1	167	1	0	0	0	0	0	0	0	1	14330	1045	37	1		1	SHANK2	11	70331427	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	1508660	70331427	64675089	82	31482											
KRTAP5-8	57830	broad.mit.edu	37	chr11	71249246	71249246	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccagcctgttcctgctccAgctgtggctcctgtgggggc	2	11	14	14	0	0	0	0	0	0	0	3	0	3	0	5	3	4	4	5	3	0	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:71249246A>C	uc001oqr.1	+	1	176	c.145A>C	c.(145-147)AGC>CGC	p.S49R		NM_021046	NP_066384	O75690	KRA58_HUMAN	keratin associated protein 5-8	49	9 X 4 AA repeats of C-C-X-P.					extracellular region|keratin filament	structural constituent of epidermis				0						TTCCTGCTCCAGCTGTGGCTC	0.682													14	321					0	0	0	0	C	71249246	C	C	71249246	3	2	167	1	0	0	0	0	1	0	0	0	8607	188	7	5	147	5	KRTAP5-8	11	71249246	Missense_Mutation	SNP	A	TCGA-CR-7404-01A-11D-2129-08	917819	71249246	63757270	83	31483											
MAP6	4135	broad.mit.edu	37	chr11	75316987	75316987	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcttgtctttggccttcctCgtgggcttatggctcgctga	2	16	12	11	2	1	1	0	1	1	0	4	1	2	1	2	3	1	4	2	3	1	4	rs139425764	byFrequency	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr11:75316987C>T	uc001owu.2	-	3	1247	c.1182G>A	c.(1180-1182)ACG>ACA	p.T394T	MAP6_uc001owv.2_Silent_p.T394T	NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	394	Calmodulin-binding (By similarity).					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					TGGCCTTCCTCGTGGGCTTAT	0.532													14	40					0	0	0	0	T	75316987	T	T	75316987	2	4	167	1	0	0	0	0	0	0	0	1	9317	871	31	1		1	MAP6	11	75316987	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	4067741	75316987	59689529	84	31484											
LRP6	4040	broad.mit.edu	37	chr12	12284974	12284974	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaaacaagtaaactgctgagGagaacatgttggaggttctt	14	10	12	5	0	1	2	0	1	1	1	1	5	1	3	0	3	4	4	0	3	5	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:12284974G>A	uc001rah.3	-	18	3893	c.3751C>T	c.(3751-3753)CCT>TCT	p.P1251S	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Intron	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1251	Extracellular (Potential).|LDL-receptor class A 1.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				AACTGCTGAGGAGAACATGTT	0.453													5	74					0	0	0	0	A	12284974	A	A	12284974	3	1	167	1	0	0	0	0	1	0	0	0	9012	1174	41	2	1114	2	LRP6	12	12284974	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08		12284974	121566921	85	31485											
EPS8	2059	broad.mit.edu	37	chr12	15800065	15800065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccattaaatgttacctatCtatatggcgattagaagttg	12	14	8	7	1	1	1	0	0	1	1	1	2	1	1	2	1	1	2	2	1	8	7			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:15800065C>T	uc009zif.2	-	15	1658	c.1564G>A	c.(1564-1566)GAT>AAT	p.D522N	EPS8_uc001rdb.2_Missense_Mutation_p.D522N|EPS8_uc009zig.2_Missense_Mutation_p.D262N|EPS8_uc010shv.1_Missense_Mutation_p.D262N	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	522					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		TGTTACCTATCTATATGGCGA	0.448													7	74					0	0	0	0	T	15800065	T	T	15800065	3	4	167	1	0	0	0	0	1	0	0	0	5218	913	32	2	932	2	EPS8	12	15800065	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	3515091	15800065	118051830	86	31486											
SLCO1C1	53919	broad.mit.edu	37	chr12	20890094	20890094	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttttcagattgcaactcaaGatgcaaatgttcagagacaa	15	11	7	8	0	3	3	3	0	0	3	3	4	3	3	0	0	3	3	0	0	4	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:20890094G>C	uc001rej.3	+	12	1791	c.1436G>C	c.(1435-1437)AGA>ACA	p.R479T	SLCO1C1_uc010sii.1_Missense_Mutation_p.R479T|SLCO1C1_uc010sij.1_Missense_Mutation_p.R430T|SLCO1C1_uc009zip.2_Missense_Mutation_p.R313T|SLCO1C1_uc001rei.2_Missense_Mutation_p.R479T|SLCO1C1_uc010sik.1_Missense_Mutation_p.R361T	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	479	Extracellular (Potential).|Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TGCAACTCAAGATGCAAATGT	0.388													3	37					0	0	0	0	C	20890094	C	C	20890094	3	2	167	1	0	0	0	0	1	0	0	0	14789	942	33	2	1474	2	SLCO1C1	12	20890094	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	5090029	20890094	112961801	87	31487											
SYT10	341359	broad.mit.edu	37	chr12	33532834	33532834	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcatttcattccagtggtctCgcccaagaccctcagcatcc	8	10	7	16	1	3	1	2	0	1	1	6	1	5	1	4	1	1	2	4	1	1	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:33532834C>T	uc001rll.1	-	6	1730	c.1433G>A	c.(1432-1434)CGA>CAA	p.R478Q	SYT10_uc009zju.1_Missense_Mutation_p.R288Q	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	478	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CCAGTGGTCTCGCCCAAGACC	0.458													22	89					0	0	0	0	T	33532834	T	T	33532834	3	4	167	1	0	0	0	0	1	0	0	0	15532	884	31	1	146	1	SYT10	12	33532834	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	12642740	33532834	100319061	88	31488											
NCKAP5L	57701	broad.mit.edu	37	chr12	50186313	50186313	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccggctgccctagtattgggGaaggtccagttcttggccag	6	10	14	11	1	1	0	0	0	1	0	2	1	2	1	4	5	1	3	4	5	3	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:50186313G>A	uc009zlk.2	-	12	3910	c.3708C>T	c.(3706-3708)TTC>TTT	p.F1236F	NCKAP5L_uc001rvc.3_Silent_p.F440F|NCKAP5L_uc001rvb.2_Silent_p.F829F	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	1232	Pro-rich.									central_nervous_system(1)	1						TAGTATTGGGGAAGGTCCAGT	0.632													5	46					0	0	0	0	A	50186313	A	A	50186313	2	1	167	1	0	0	0	0	0	0	0	1	10278	1165	41	2		2	NCKAP5L	12	50186313	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	16653479	50186313	83665582	89	31489											
CMKLR1	1240	broad.mit.edu	37	chr12	108686010	108686010	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgcgctgcagtttgcacaCgatggtgaggtagcaagctg	8	10	15	8	2	0	1	0	1	0	0	0	2	0	1	0	2	5	8	0	2	2	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:108686010C>T	uc009zuw.2	-	3	921	c.730G>A	c.(730-732)GTG>ATG	p.V244M	CMKLR1_uc001tmw.2_Missense_Mutation_p.V244M|CMKLR1_uc001tmv.2_Missense_Mutation_p.V242M|CMKLR1_uc009zuv.2_Missense_Mutation_p.V244M	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	244	Helical; Name=5; (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						AGTTTGCACACGATGGTGAGG	0.557													4	38					0	0	0	0	T	108686010	T	T	108686010	3	4	167	1	0	0	0	0	1	0	0	0	3594	536	19	1	395	1	CMKLR1	12	108686010	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	58499697	108686010	25165885	90	31490											
KSR2	283455	broad.mit.edu	37	chr12	117977627	117977627	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggtgctggcgaggagggCgtggaggacgtcgtggagga	6	5	25	5	4	0	0	0	0	0	0	1	6	0	5	0	9	1	1	0	9	0	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:117977627C>T	uc001two.2	-	10	1552	c.1497G>A	c.(1495-1497)ACG>ACA	p.T499T		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	528	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCGAGGAGGGCGTGGAGGACG	0.632													11	34					0	0	0	0	T	117977627	T	T	117977627	2	4	167	1	0	0	0	0	0	0	0	1	8622	755	27	1		1	KSR2	12	117977627	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	9291617	117977627	15874268	91	31491											
DNAH10	196385	broad.mit.edu	37	chr12	124330339	124330339	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accatgccgctaagcaaaaaCgacaggaaaaaatacaacac	21	3	6	11	2	0	0	0	0	0	0	0	2	0	1	2	1	5	2	2	1	8	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:124330339C>T	uc001uft.3	+	30	5224	c.5199C>T	c.(5197-5199)AAC>AAT	p.N1733N		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1733	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TAAGCAAAAACGACAGGAAAA	0.473													6	75					0	0	0	0	T	124330339	T	T	124330339	2	4	167	1	0	0	0	0	0	0	0	1	4620	535	19	1		1	DNAH10	12	124330339	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	6352712	124330339	9521556	92	31492											
DDX51	317781	broad.mit.edu	37	chr12	132626474	132626474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactctcagaggtgtggcatCtgtgtagatgttgaaaactt	10	13	12	6	0	2	3	1	1	2	2	3	4	2	3	0	2	1	3	0	2	3	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr12:132626474C>T	uc001ujy.3	-	6	955	c.916G>A	c.(916-918)GAT>AAT	p.D306N	NOC4L_uc001ujz.1_5'Flank	NM_175066	NP_778236	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	306	Helicase ATP-binding.				rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			lung(1)|pancreas(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		GGTGTGGCATCTGTGTAGATG	0.547													4	34					0	0	0	0	T	132626474	T	T	132626474	3	4	167	1	0	0	0	0	1	0	0	0	4386	913	32	2	1124	2	DDX51	12	132626474	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	8296135	132626474	1225421	93	31493											
FRY	10129	broad.mit.edu	37	chr13	32757152	32757152	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcatccattaatgaaagaagCtctggaaagaagaccagagg	17	7	10	7	0	2	5	1	1	1	4	3	6	3	6	2	2	1	1	2	2	5	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr13:32757152C>G	uc001utx.2	+	24	3531	c.3035C>G	c.(3034-3036)GCT>GGT	p.A1012G	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1012					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ATGAAAGAAGCTCTGGAAAGA	0.323													32	34					0	0	0	0	G	32757152	G	G	32757152	3	3	167	1	0	0	0	0	1	0	0	0	6097	797	28	4	3129	4	FRY	13	32757152	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08		32757152	82412726	94	31494											
TRPC4	7223	broad.mit.edu	37	chr13	38320194	38320194	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccagttctctggaacttctCgtctgatccagtaggtcctt	6	15	8	12	1	3	1	0	1	3	0	8	2	6	2	3	2	1	2	3	2	2	4	rs115609911	by1000genomes	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr13:38320194C>T	uc001uws.2	-	3	1012	c.777G>A	c.(775-777)ACG>ACA	p.T259T	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Silent_p.T259T|TRPC4_uc010tey.1_Silent_p.T259T|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Silent_p.T259T|TRPC4_uc010aby.2_Silent_p.T259T	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	259	Potential.|Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TGGAACTTCTCGTCTGATCCA	0.408													11	115					0	0	0	0	T	38320194	T	T	38320194	2	4	167	1	0	0	0	0	0	0	0	1	16647	871	31	1		1	TRPC4	13	38320194	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	5563042	38320194	76849684	95	31495											
COL4A1	1282	broad.mit.edu	37	chr13	110827073	110827073	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttctctccagggcttcctggGaaacccgctatcccttgatc	6	12	8	15	1	1	1	0	1	1	0	6	2	4	2	4	2	1	2	4	2	2	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr13:110827073G>A	uc001vqw.3	-	38	3344	c.3222C>T	c.(3220-3222)TTC>TTT	p.F1074F	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1074	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGCTTCCTGGGAAACCCGCTA	0.498													16	180					0	0	0	0	A	110827073	A	A	110827073	2	1	167	1	0	0	0	0	0	0	0	1	3704	1165	41	2		2	COL4A1	13	110827073	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	72506879	110827073	4342805	96	31496											
TFDP1	7027	broad.mit.edu	37	chr13	114290326	114290326	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaacctggtgcagagaaaccGgcatgcggagcagcaggcca	12	3	15	11	2	0	1	0	0	0	1	0	4	0	2	3	4	6	4	3	4	2	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr13:114290326G>A	uc001vtw.2	+	9	934	c.722G>A	c.(721-723)CGG>CAG	p.R241Q	TFDP1_uc010tkd.1_Missense_Mutation_p.R146Q|TFDP1_uc010tke.1_Missense_Mutation_p.R146Q|TFDP1_uc001vty.3_Missense_Mutation_p.R241Q|TFDP1_uc001vtx.2_Missense_Mutation_p.R121Q	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	241	Dimerization (Potential).|Enhances binding of RB protein to E2F.|DCB1.				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			CAGAGAAACCGGCATGCGGAG	0.587										TSP Lung(29;0.18)			9	70					0	0	0	0	A	114290326	A	A	114290326	3	1	167	1	0	0	0	0	1	0	0	0	15863	1116	39	1	752	1	TFDP1	13	114290326	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	3463253	114290326	879552	97	31497											
PTGER2	5732	broad.mit.edu	37	chr14	52794009	52794009	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaagctcttaggtttttatCaattaattcaataattgacc	13	16	4	8	0	3	1	2	1	1	0	3	1	3	1	2	1	1	2	2	1	7	8			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr14:52794009C>G	uc001wzr.2	+	2	1165	c.914C>G	c.(913-915)TCA>TGA	p.S305*		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	305	Helical; Name=7; (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	AGGTTTTTATCAATTAATTCA	0.388													13	47					0	0	0	0	G	52794009	G	G	52794009	4	3	167	1	0	0	0	0	0	1	0	0	12806	838	29	2	920	2	PTGER2	14	52794009	Nonsense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08		52794009	54555531	98	31498											
SYNE2	23224	broad.mit.edu	37	chr14	64691756	64691756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaaggcgaggaggagacaGagagcaggtaacggggcttt	13	4	18	6	2	0	3	0	0	0	3	0	7	0	4	0	6	2	3	0	6	2	2	rs146398606	byFrequency	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr14:64691756G>A	uc001xgm.2	+	114	20673	c.20443G>A	c.(20443-20445)GAG>AAG	p.E6815K	SYNE2_uc001xgl.2_Missense_Mutation_p.E6837K|SYNE2_uc010apy.2_Missense_Mutation_p.E3200K|SYNE2_uc001xgn.2_Missense_Mutation_p.E1776K|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.E785K|SYNE2_uc001xgq.2_Missense_Mutation_p.E1194K|SYNE2_uc001xgr.2_Missense_Mutation_p.E598K|SYNE2_uc010tsi.1_Missense_Mutation_p.E472K|SYNE2_uc001xgs.2_Missense_Mutation_p.E486K|SYNE2_uc001xgt.2_Missense_Mutation_p.E359K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6815	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GGAGGAGACAGAGAGCAGGTA	0.488													7	22					0	0	0	0	A	64691756	A	A	64691756	3	1	167	1	0	0	0	0	1	0	0	0	15512	943	33	2	21008	2	SYNE2	14	64691756	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	11897747	64691756	42657784	99	31499											
GTF2A1	2957	broad.mit.edu	37	chr14	81659171	81659171	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgaaatccctccaggaaGaggagccagcacctaaagca	14	5	11	11	0	0	2	0	1	0	1	2	4	2	4	4	3	3	2	4	3	4	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr14:81659171G>A	uc001xvf.1	-	7	1057	c.625C>T	c.(625-627)CTT>TTT	p.L209F	GTF2A1_uc010atb.1_Missense_Mutation_p.L159F|GTF2A1_uc001xvg.1_Missense_Mutation_p.L170F	NM_015859	NP_056943	P52655	TF2AA_HUMAN	TFIIA alpha, p55 isoform 1	209					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|transcription factor TFIIA complex	DNA binding|protein binding|protein heterodimerization activity|TBP-class protein binding|transcription coactivator activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0287)		CCTCCAGGAAGAGGAGCCAGC	0.413													7	137					0	0	0	0	A	81659171	A	A	81659171	3	1	167	1	0	0	0	0	1	0	0	0	6891	942	33	2	517	2	GTF2A1	14	81659171	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	16967415	81659171	25690369	100	31500											
KCNK13	56659	broad.mit.edu	37	chr14	90650623	90650623	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagcggcagctccggagacGaggggccctgccccaggaga	8	2	16	15	3	0	2	0	0	0	2	1	5	1	2	5	5	3	2	5	5	0	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr14:90650623G>A	uc001xye.1	+	2	945	c.503G>A	c.(502-504)CGA>CAA	p.R168Q		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	168	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				CTCCGGAGACGAGGGGCCCTG	0.607													22	77					0	0	0	0	A	90650623	A	A	90650623	3	1	167	1	0	0	0	0	1	0	0	0	8100	1058	37	1	509	1	KCNK13	14	90650623	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	8991452	90650623	16698917	101	31501											
CHGA	1113	broad.mit.edu	37	chr14	93397717	93397717	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccctcccggagcccatgcagGagtccaaggctgaggggaac	9	4	14	14	1	0	1	0	1	0	0	2	4	2	4	4	5	3	2	4	5	2	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr14:93397717G>A	uc001ybc.3	+	6	738	c.478G>A	c.(478-480)GAG>AAG	p.E160K	CHGA_uc010aum.2_RNA|CHGA_uc001ybd.3_Intron	NM_001275	NP_001266	P10645	CMGA_HUMAN	chromogranin A precursor	160					regulation of blood pressure	extracellular region|stored secretory granule				skin(2)	2		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		GCCCATGCAGGAGTCCAAGGC	0.532													4	20					0	0	0	0	A	93397717	A	A	93397717	3	1	167	1	0	0	0	0	1	0	0	0	3353	1175	41	2	500	2	CHGA	14	93397717	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	2747094	93397717	13951823	102	31502											
B2M	567	broad.mit.edu	37	chr15	45007775	45007775	+	Frame_Shift_Del	DEL	G	-	-																															aaagtggagcattcagacttGtctttcagcaaggactggtc																										TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr15:45007775delG	uc001zuc.2	+	2	282	c.222delG	c.(220-222)TTGfs	p.L74fs	B2M_uc010uek.1_Frame_Shift_Del_p.L74fs|B2M_uc010bdx.1_Intron	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	74	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		ATTCAGACTTGTCTTTCAGCA	0.418													---	---	---								-	45007775	-	-	45007775	7	5	167	1	0	1	0	1	0	0	0	0	1246	1368	48	0	228	0	B2M	15	45007775	Frame_Shift_Del	DEL	G	TCGA-CR-7404-01A-11D-2129-08		45007775	57523617	103	31503											
ACSBG1	23205	broad.mit.edu	37	chr15	78465941	78465941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggaaaaacctacccaactCtccacccgaaatggagaagt	17	5	7	12	1	1	1	0	0	1	1	2	4	1	2	4	2	3	0	4	2	7	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr15:78465941C>G	uc002bdh.2	-	13	2139	c.2083G>C	c.(2083-2085)GAG>CAG	p.E695Q	ACSBG1_uc010umw.1_Missense_Mutation_p.E691Q|ACSBG1_uc010umx.1_Missense_Mutation_p.E453Q	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	695					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						CTACCCAACTCTCCACCCGAA	0.587													8	43					0	0	0	0	G	78465941	G	G	78465941	3	3	167	1	0	0	0	0	1	0	0	0	173	922	32	2	99	2	ACSBG1	15	78465941	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	33458166	78465941	24065451	104	31504											
ZNF592	9640	broad.mit.edu	37	chr15	85328024	85328024	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacccagaccctgtgaggctCatccggtactcaatcaagtg	10	9	9	13	1	3	2	3	1	0	1	4	2	4	2	3	2	2	2	3	2	4	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr15:85328024C>T	uc002bld.2	+	4	2454	c.2118C>T	c.(2116-2118)CTC>CTT	p.L706L	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	706					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTGTGAGGCTCATCCGGTACT	0.582													7	70					0	0	0	0	T	85328024	T	T	85328024	2	4	167	1	0	0	0	0	0	0	0	1	18089	813	29	2		2	ZNF592	15	85328024	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	6862083	85328024	17203368	105	31505											
C16orf91	283951	broad.mit.edu	37	chr16	1470388	1470388	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccagatgatcagcgccacGaggaagcagctgaggggcag	12	3	15	11	2	1	3	1	2	0	1	1	5	1	4	2	3	3	3	2	3	1	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:1470388G>A	uc002clr.2	-	2	279	c.258C>T	c.(256-258)CTC>CTT	p.L86L	C16orf91_uc010uvd.1_Silent_p.L243L	NM_001010878	NP_001010878	Q4G0I0	CSMT1_HUMAN	hypothetical protein LOC283951	86	Helical; (Potential).					integral to membrane					0						TCAGCGCCACGAGGAAGCAGC	0.632													15	74					0	0	0	0	A	1470388	A	A	1470388	2	1	167	1	0	0	0	0	0	0	0	1	1850	1045	37	1		1	C16orf91	16	1470388	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08		1470388	88884365	106	31506											
COQ7	10229	broad.mit.edu	37	chr16	19085308	19085308	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttgatggttacgttcagggtCcggccaacagttctgatgcc	7	12	12	10	2	2	2	1	2	1	0	3	2	3	2	3	3	3	3	3	3	2	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:19085308C>G	uc002dfr.2	+	3	378	c.318C>G	c.(316-318)GTC>GTG	p.V106V	COQ7_uc002dfs.2_Silent_p.V92V	NM_016138	NP_057222	Q99807	COQ7_HUMAN	COQ7 protein	106	1.|2 X approximate tandem repeats.				ubiquinone biosynthetic process	mitochondrial inner membrane|nucleus	oxidoreductase activity|transition metal ion binding			skin(1)	1						CGTTCAGGGTCCGGCCAACAG	0.438													5	23					0	0	0	0	G	19085308	G	G	19085308	2	3	167	1	0	0	0	0	0	0	0	1	3765	842	30	2		2	COQ7	16	19085308	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	17614920	19085308	71269445	107	31507											
TMC5	79838	broad.mit.edu	37	chr16	19505660	19505660	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagaaagcaaaccccagctCacttgttctggaaaggagag	15	6	11	9	0	2	2	1	0	1	2	2	5	2	3	2	2	3	3	2	2	4	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:19505660C>T	uc002dgc.3	+	20	3652	c.2903C>T	c.(2902-2904)TCA>TTA	p.S968L	TMC5_uc010vaq.1_Missense_Mutation_p.S916L|TMC5_uc002dgb.3_Missense_Mutation_p.S910L|TMC5_uc010var.1_Missense_Mutation_p.S968L|TMC5_uc002dge.3_Missense_Mutation_p.S722L|TMC5_uc002dgf.3_Missense_Mutation_p.S651L|TMC5_uc002dgg.3_Missense_Mutation_p.S609L	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	968	Extracellular (Potential).					integral to membrane				skin(1)	1						AACCCCAGCTCACTTGTTCTG	0.488													23	116					0	0	0	0	T	19505660	T	T	19505660	3	4	167	1	0	0	0	0	1	0	0	0	16054	838	29	2	3287	2	TMC5	16	19505660	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	420352	19505660	70849093	108	31508											
ATXN2L	11273	broad.mit.edu	37	chr16	28843600	28843600	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagcttcctgtccagagcctCccatcggctcggcagtgcca	6	8	10	17	2	0	1	0	0	0	1	5	1	3	1	5	2	3	3	5	2	0	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:28843600C>T	uc002drc.2	+	11	1564	c.1396C>T	c.(1396-1398)CCC>TCC	p.P466S	uc010vct.1_Intron|ATXN2L_uc010byl.1_Missense_Mutation_p.P466S|ATXN2L_uc002drb.2_Missense_Mutation_p.P466S|ATXN2L_uc002dqy.2_Missense_Mutation_p.P466S|ATXN2L_uc002dra.2_Missense_Mutation_p.P466S|ATXN2L_uc002dqz.2_Missense_Mutation_p.P466S|ATXN2L_uc010vdb.1_Missense_Mutation_p.P472S|ATXN2L_uc002dre.2_Missense_Mutation_p.P466S|ATXN2L_uc002drf.2_Intron|ATXN2L_uc002drg.2_5'Flank	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	466						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TCCAGAGCCTCCCATCGGCTC	0.587													10	53					0	0	0	0	T	28843600	T	T	28843600	3	4	167	1	0	0	0	0	1	0	0	0	1214	855	30	2	1438	2	ATXN2L	16	28843600	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	9337940	28843600	61511153	109	31509											
SETD1A	9739	broad.mit.edu	37	chr16	30990939	30990939	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcctgctgttgaagactcaGaggccacagagacatcggac	11	7	12	11	1	1	4	1	1	0	3	2	6	1	5	2	2	2	2	2	2	1	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:30990939G>C	uc002ead.1	+	14	4518	c.3832G>C	c.(3832-3834)GAG>CAG	p.E1278Q		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						TGAAGACTCAGAGGCCACAGA	0.701													6	21					0	0	0	0	C	30990939	C	C	30990939	3	2	167	1	0	0	0	0	1	0	0	0	14195	943	33	2	3882	2	SETD1A	16	30990939	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	2147339	30990939	59363814	110	31510											
ZNF423	23090	broad.mit.edu	37	chr16	49672148	49672148	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgagcagtgtgttctcgtcGacgaagacctcagggcagtg	8	8	15	10	4	2	1	1	0	1	1	4	4	2	1	1	1	1	3	1	1	1	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:49672148G>A	uc002efs.2	-	5	1213	c.915C>T	c.(913-915)GTC>GTT	p.V305V	ZNF423_uc010vgn.1_Silent_p.V188V	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	305	C2H2-type 7.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				TGTTCTCGTCGACGAAGACCT	0.607													10	31					0	0	0	0	A	49672148	A	A	49672148	2	1	167	1	0	0	0	0	0	0	0	1	17965	1045	37	1		1	ZNF423	16	49672148	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	18681209	49672148	40682605	111	31511											
KIAA0182	23199	broad.mit.edu	37	chr16	85697133	85697133	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacccgctacagccctgatGagatgaacaacagtcccaac	13	6	7	15	1	0	3	0	3	0	1	1	4	1	3	3	0	6	1	3	0	5	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr16:85697133G>A	uc002fix.2	+	11	2631	c.2557G>A	c.(2557-2559)GAG>AAG	p.E853K	KIAA0182_uc002fiw.2_Missense_Mutation_p.E749K|KIAA0182_uc002fiy.2_Missense_Mutation_p.E780K|KIAA0182_uc002fiz.2_Missense_Mutation_p.E33K|KIAA0182_uc010cho.2_Missense_Mutation_p.E33K	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	853							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						CAGCCCTGATGAGATGAACAA	0.562													21	55					0	0	0	0	A	85697133	A	A	85697133	3	1	167	1	0	0	0	0	1	0	0	0	8198	1291	45	2	2599	2	KIAA0182	16	85697133	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	36024985	85697133	4657620	112	31512											
PER1	5187	broad.mit.edu	37	chr17	8045157	8045157	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgaggcagttggcccttcCggacccaggagtgcacagca	8	5	13	15	2	0	0	0	0	0	0	1	3	1	2	4	4	2	4	4	4	0	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:8045157C>T	uc002gkd.2	-	22	3804	c.3566G>A	c.(3565-3567)CGG>CAG	p.R1189Q	PER1_uc010cns.2_Missense_Mutation_p.R63Q|PER1_uc010vuq.1_RNA	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	1189	CRY binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						TTGGCCCTTCCGGACCCAGGA	0.577			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					20	116					0	0	0	0	T	8045157	T	T	8045157	3	4	167	1	0	0	0	0	1	0	0	0	11783	652	23	1	314	1	PER1	17	8045157	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08		8045157	73150053	113	31513											
DNAH9	1770	broad.mit.edu	37	chr17	11520897	11520897	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccgctccccgggaaggctGactgtgctgctccaggagat	7	8	13	13	2	0	2	0	1	0	1	2	4	2	3	4	3	3	4	4	3	2	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:11520897G>A	uc002gne.2	+	5	1142	c.1074G>A	c.(1072-1074)CTG>CTA	p.L358L		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	358	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CGGGAAGGCTGACTGTGCTGC	0.612													5	79					0	0	0	0	A	11520897	A	A	11520897	2	1	167	1	0	0	0	0	0	0	0	1	4630	1277	45	2		2	DNAH9	17	11520897	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	3475740	11520897	69674313	114	31514											
MYO15A	51168	broad.mit.edu	37	chr17	18025472	18025472	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttttgctgtggtcatgcctCgtgtgcagaagctgagctct	5	14	13	9	1	2	2	1	1	1	1	3	2	2	2	1	1	5	5	1	1	1	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:18025472C>T	uc010vxh.1	+	2	3696	c.3358C>T	c.(3358-3360)CGT>TGT	p.R1120C		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1120	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GGTCATGCCTCGTGTGCAGAA	0.652													12	44					0	0	0	0	T	18025472	T	T	18025472	3	4	167	1	0	0	0	0	1	0	0	0	10116	884	31	1	3360	1	MYO15A	17	18025472	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	6504575	18025472	63169738	115	31515											
CCDC144NL	339184	broad.mit.edu	37	chr17	20799179	20799179	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgacgctgttcttccaccagCtgtaggagaagcccaaggac	10	7	11	13	2	1	1	0	0	1	1	2	4	2	2	3	2	2	4	3	2	3	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:20799179C>G	uc002gyf.2	-	1	275	c.155G>C	c.(154-156)AGC>ACC	p.S52T	uc002gyg.1_Intron|uc002gyh.1_Intron	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	52											0						CTTCCACCAGCTGTAGGAGAA	0.622													4	72					0	0	0	0	G	20799179	G	G	20799179	3	3	167	1	0	0	0	0	1	0	0	0	2791	797	28	4	526	4	CCDC144NL	17	20799179	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	2773707	20799179	60396031	116	31516											
SEZ6	124925	broad.mit.edu	37	chr17	27286455	27286455	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagttgggagagagtaccaCgccagccgagtctgtgatct	9	8	13	11	2	2	2	0	1	2	1	2	5	2	3	4	1	2	2	4	1	1	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:27286455C>T	uc002hdp.2	-	9	2001	c.1807G>A	c.(1807-1809)GTG>ATG	p.V603M	SEZ6_uc010crx.1_5'Flank|SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.V603M|SEZ6_uc002hdq.1_Missense_Mutation_p.V478M	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	603	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			GAGAGTACCACGCCAGCCGAG	0.587													13	42					0	0	0	0	T	27286455	T	T	27286455	3	4	167	1	0	0	0	0	1	0	0	0	14207	536	19	1	1226	1	SEZ6	17	27286455	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	6487276	27286455	53908755	117	31517											
STAT5A	6776	broad.mit.edu	37	chr17	40458324	40458324	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgtgaggcgctcaacatGaaattcaaggccgaagtgca	12	8	12	9	2	2	2	2	2	0	0	2	3	2	2	1	2	2	2	1	2	4	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:40458324G>A	uc002hzj.1	+	14	2181	c.1539G>A	c.(1537-1539)ATG>ATA	p.M513I	STAT5A_uc010cya.1_Missense_Mutation_p.M513I|STAT5A_uc010cyb.1_Missense_Mutation_p.M482I|STAT5A_uc010cyc.1_Missense_Mutation_p.M483I|STAT5A_uc010cyd.1_Missense_Mutation_p.M1I|STAT5A_uc010cye.1_Missense_Mutation_p.M1I	NM_003152	NP_003143	P42229	STA5A_HUMAN	signal transducer and activator of transcription	513					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		CGCTCAACATGAAATTCAAGG	0.572													12	65					0	0	0	0	A	40458324	A	A	40458324	3	1	167	1	0	0	0	0	1	0	0	0	15334	1290	45	2	1585	2	STAT5A	17	40458324	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	13171869	40458324	40736886	118	31518											
BRCA1	672	broad.mit.edu	37	chr17	41243826	41243826	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacggtgctatgcctagtaGactgagaaggtatattgttt	11	13	11	6	1	0	2	0	1	0	2	0	3	0	2	1	2	3	4	1	2	7	7	rs80357143		TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:41243826G>A	uc002icq.2	-	10	3954	c.3722C>T	c.(3721-3723)TCT>TTT	p.S1241F	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.S1170F|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.S1194F|BRCA1_uc002ict.2_Missense_Mutation_p.S1241F|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.S1241F|BRCA1_uc002ide.1_Missense_Mutation_p.S1072F|BRCA1_uc010cyy.1_Missense_Mutation_p.S1241F|BRCA1_uc010whs.1_Missense_Mutation_p.S1241F|BRCA1_uc010cyz.2_Missense_Mutation_p.S1194F|BRCA1_uc010cza.2_Missense_Mutation_p.S1215F|BRCA1_uc010wht.1_Missense_Mutation_p.S945F	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1241					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ATGCCTAGTAGACTGAGAAGG	0.388			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			6	116					0	0	0	0	A	41243826	A	A	41243826	3	1	167	1	0	0	0	0	1	0	0	0	1503	942	33	2	1995	2	BRCA1	17	41243826	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	785502	41243826	39951384	119	31519											
BRCA1	672	broad.mit.edu	37	chr17	41245102	41245102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attatctttggaacaaccatGaattagtcccttggggtttt	10	16	8	7	0	1	1	0	1	1	0	2	2	2	2	2	3	2	1	2	3	5	6			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:41245102G>A	uc002icq.2	-	10	2678	c.2446C>T	c.(2446-2448)CAT>TAT	p.H816Y	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.H745Y|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.H769Y|BRCA1_uc002ict.2_Missense_Mutation_p.H816Y|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.H816Y|BRCA1_uc002ide.1_Missense_Mutation_p.H647Y|BRCA1_uc010cyy.1_Missense_Mutation_p.H816Y|BRCA1_uc010whs.1_Missense_Mutation_p.H816Y|BRCA1_uc010cyz.2_Missense_Mutation_p.H769Y|BRCA1_uc010cza.2_Missense_Mutation_p.H790Y|BRCA1_uc010wht.1_Missense_Mutation_p.H520Y	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	816					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GAACAACCATGAATTAGTCCC	0.398			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			14	248					0	0	0	0	A	41245102	A	A	41245102	3	1	167	1	0	0	0	0	1	0	0	0	1503	1290	45	2	3271	2	BRCA1	17	41245102	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	1276	41245102	39950108	120	31520											
C17orf28	283987	broad.mit.edu	37	chr17	72955024	72955024	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accttgttgaagtcgcagagCttccagaagagaactagcag	13	8	11	9	1	0	4	0	1	0	3	2	5	1	4	2	0	3	4	2	0	4	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:72955024C>A	uc002jmj.3	-	9	1280	c.1131G>T	c.(1129-1131)AAG>AAT	p.K377N	C17orf28_uc010wrs.1_Missense_Mutation_p.K176N|C17orf28_uc002jmk.2_Missense_Mutation_p.K376N	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	377						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					AGTCGCAGAGCTTCCAGAAGA	0.602											OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	14					6.4e-05	6.93933e-05	1	0	A	72955024	A	A	72955024	3	1	167	1	0	0	0	0	1	0	0	0	1860	796	28	4	1279	4	C17orf28	17	72955024	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	31709922	72955024	8240186	121	31521											
C17orf101	79701	broad.mit.edu	37	chr17	80363226	80363226	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccggaagtcctcctctgaGaagatgttctgtattttatc	10	14	8	9	1	2	2	0	1	2	2	5	4	4	3	3	1	1	2	3	1	5	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:80363226G>A	uc002keu.1	-	6	620	c.519C>T	c.(517-519)TTC>TTT	p.F173F	C17orf101_uc002ket.1_Silent_p.F173F|C17orf101_uc010dip.1_RNA	NM_024648	NP_078924	Q6PK18	CQ101_HUMAN	hypothetical protein LOC79701 isoform 1	173	Lumenal (Potential).					integral to membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)	1						CCTCCTCTGAGAAGATGTTCT	0.517													12	31					0	0	0	0	A	80363226	A	A	80363226	2	1	167	1	0	0	0	0	0	0	0	1	1854	933	33	2		2	C17orf101	17	80363226	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	7408202	80363226	831984	122	31522											
ZNF750	79755	broad.mit.edu	37	chr17	80790043	80790044	+	Frame_Shift_Del	DEL	AG	-	-																															tgaagcttcgagtcgaaggcAgagagtccatttgcgacaga																										TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr17:80790043_80790044delAG	uc002kga.2	-	2	598_599	c.287_288delCT	c.(286-288)TCTfs	p.S96fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	96						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGTCGAAGGCAGAGAGTCCATT	0.574													---	---	---								-	80790044	-	-	80790043	7	5	167	1	0	1	0	1	0	0	0	0	18199	175	7	0	1891	0	ZNF750	17	80790043	Frame_Shift_Del	DEL	AG	TCGA-CR-7404-01A-11D-2129-08	426817	80790043	405167	123	31523											
KIAA0802	23255	broad.mit.edu	37	chr18	8784808	8784808	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcccgggactcccccatcggGaacctggggaaggagctggg	7	5	16	13	2	0	0	0	0	0	0	3	4	2	4	4	6	2	1	4	6	2	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr18:8784808G>C	uc002knr.2	+	6	1840	c.1698G>C	c.(1696-1698)GGG>GGC	p.G566G	KIAA0802_uc002knq.2_Silent_p.G566G|KIAA0802_uc010dkw.1_Silent_p.G404G	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	917											0						CCCCCATCGGGAACCTGGGGA	0.632													11	58					0	0	0	0	C	8784808	C	C	8784808	2	2	167	1	0	0	0	0	0	0	0	1	8233	1161	41	2		2	KIAA0802	18	8784808	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08		8784808	69292440	124	31524											
CCDC11	220136	broad.mit.edu	37	chr18	47765019	47765019	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttaagttctttaagactttCatttatgtgtttctgttcca	8	21	6	6	0	3	1	1	0	2	1	4	1	4	1	1	0	0	4	1	0	3	9			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr18:47765019C>T	uc002lee.2	-	7	1361	c.1270G>A	c.(1270-1272)GAA>AAA	p.E424K		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	424	Potential.									ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		TTAAGACTTTCATTTATGTGT	0.313													9	33					0	0	0	0	T	47765019	T	T	47765019	3	4	167	1	0	0	0	0	1	0	0	0	2758	835	29	2	282	2	CCDC11	18	47765019	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	38980211	47765019	30312229	125	31525											
MIER2	54531	broad.mit.edu	37	chr19	327204	327204	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgaggtcgtcagcagatGattgcgtctcttcctcttct	5	14	12	10	2	4	3	1	2	3	1	7	3	5	3	1	2	2	1	1	2	0	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:327204G>T	uc002lok.1	-	5	431	c.422C>A	c.(421-423)TCA>TAA	p.S141*		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCAGCAGATGATTGCGTCTC	0.468													12	216					3.07112e-06	3.36776e-06	1	0	T	327204	T	T	327204	4	4	167	1	0	0	0	0	0	1	0	0	9634	1294	45	2	1255	2	MIER2	19	327204	Nonsense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08		327204	58801779	126	31526											
MPND	84954	broad.mit.edu	37	chr19	4359198	4359198	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacaagggttcccctgacctCgtgaggctccaggaaccctg	8	8	11	14	1	0	2	0	2	0	0	3	3	2	3	5	3	2	2	5	3	3	2	rs141733787	by1000genomes	TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:4359198C>T	uc002mae.2	+	11	1342	c.1275C>T	c.(1273-1275)CTC>CTT	p.L425L	MPND_uc010dtx.2_RNA|MPND_uc002mag.2_Silent_p.L405L|MPND_uc002maf.2_Silent_p.L455L|MPND_uc002mah.2_Silent_p.L313L|MPND_uc002mai.2_Silent_p.L314L	NM_032868	NP_116257	Q8N594	MPND_HUMAN	MPN domain containing isoform 1	425							peptidase activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCTGACCTCGTGAGGCTCC	0.622													10	55					0	0	0	0	T	4359198	T	T	4359198	2	4	167	1	0	0	0	0	0	0	0	1	9784	871	31	1		1	MPND	19	4359198	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	4031994	4359198	54769785	127	31527											
ZNF98	148198	broad.mit.edu	37	chr19	22575483	22575483	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaatgacttttcacattctTtacacttgaaagatttcttt	13	18	3	7	0	3	3	1	2	2	1	3	3	3	3	0	0	1	0	0	0	4	8			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:22575483T>C	uc002nqt.2	-	4	676	c.554A>G	c.(553-555)AAA>AGA	p.K185R		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	185	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				TTCACATTCTTTACACTTGAA	0.303													2	8					0	0	0	0	C	22575483	C	C	22575483	3	2	167	1	0	0	0	0	1	0	0	0	18270	1841	64	5	1168	5	ZNF98	19	22575483	Missense_Mutation	SNP	T	TCGA-CR-7404-01A-11D-2129-08	18216285	22575483	36553500	128	31528											
PVRL2	5819	broad.mit.edu	37	chr19	45375325	45375325	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgccctcgggccgagcaGatggtgtcacggtcacctgc	5	8	15	13	3	2	1	2	0	0	1	3	2	2	1	3	4	3	1	3	4	0	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:45375325G>A	uc002ozw.1	+	3	1084	c.694G>A	c.(694-696)GAT>AAT	p.D232N	PVRL2_uc002ozv.2_Missense_Mutation_p.D232N	NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	232	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		GGGCCGAGCAGATGGTGTCAC	0.597													5	63					0	0	0	0	A	45375325	A	A	45375325	3	1	167	1	0	0	0	0	1	0	0	0	12905	942	33	2	704	2	PVRL2	19	45375325	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	22799842	45375325	13753658	129	31529											
PVRL2	5819	broad.mit.edu	37	chr19	45375367	45375367	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagtggagcatgagagcttcGaggaaccagccctgatacct	12	7	12	10	1	0	2	0	2	0	1	1	6	0	4	3	2	5	2	3	2	3	2	rs138153191		TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:45375367G>A	uc002ozw.1	+	3	1126	c.736G>A	c.(736-738)GAG>AAG	p.E246K	PVRL2_uc002ozv.2_Missense_Mutation_p.E246K	NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	246	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		TGAGAGCTTCGAGGAACCAGC	0.592													5	73					0	0	0	0	A	45375367	A	A	45375367	3	1	167	1	0	0	0	0	1	0	0	0	12905	1059	37	1	746	1	PVRL2	19	45375367	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	42	45375367	13753616	130	31530											
NLRP12	91662	broad.mit.edu	37	chr19	54313983	54313983	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctcctcccagcagaggcaCcagggtccctgaggatcgtg	7	8	12	14	1	1	2	0	1	1	1	5	3	3	3	4	3	1	2	4	3	0	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:54313983C>A	uc002qch.3	-	3	1150	c.930G>T	c.(928-930)TGG>TGT	p.W310C	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.W310C|NLRP12_uc002qcj.3_Missense_Mutation_p.W310C|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.W310C	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	310	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AGCAGAGGCACCAGGGTCCCT	0.572													6	57					3.59834e-05	3.92361e-05	1	0	A	54313983	A	A	54313983	3	1	167	1	0	0	0	0	1	0	0	0	10528	508	18	4	2383	4	NLRP12	19	54313983	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	8938616	54313983	4815000	131	31531											
PEG3	5178	broad.mit.edu	37	chr19	57335885	57335885	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattaggttccgaaacctctGatgaaaaaactcagagtcag	15	9	9	8	1	3	3	2	2	1	1	4	5	4	3	2	1	2	1	2	1	5	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:57335885G>C	uc002qnu.2	-	1	490	c.139C>G	c.(139-141)CAG>GAG	p.Q47E	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.Q47E|PEG3_uc002qnv.2_Missense_Mutation_p.Q47E|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Missense_Mutation_p.Q47E	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	47	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CGAAACCTCTGATGAAAAAAC	0.502													14	51					0	0	0	0	C	57335885	C	C	57335885	3	2	167	1	0	0	0	0	1	0	0	0	11774	1299	45	2		2	PEG3	19	57335885	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	3021902	57335885	1793098	132	31532											
ZNF547	284306	broad.mit.edu	37	chr19	57889020	57889020	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcctttctttgtaagtctCaccttgttcgtcaccagaca	9	14	6	12	1	3	1	2	0	2	1	5	1	3	1	3	0	1	2	3	0	2	5			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr19:57889020C>G	uc002qol.2	+	4	869	c.676C>G	c.(676-678)CAC>GAC	p.H226D	ZNF547_uc002qpm.3_Missense_Mutation_p.H152D|ZNF547_uc010ygx.1_Missense_Mutation_p.H226D	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	226	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTGTAAGTCTCACCTTGTTCG	0.433													5	84					0	0	0	0	G	57889020	G	G	57889020	3	3	167	1	0	0	0	0	1	0	0	0	18046	826	29	2	686	2	ZNF547	19	57889020	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	553135	57889020	1239963	133	31533											
CSNK2A1	1457	broad.mit.edu	37	chr20	468206	468206	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggacaaagcgttcccatcGctttcgagagtgtctgcagg	8	10	13	10	3	1	1	0	0	1	1	4	3	2	2	1	2	2	3	1	2	1	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:468206G>A	uc002wdw.1	-	12	1231	c.838C>T	c.(838-840)CGA>TGA	p.R280*	CSNK2A1_uc002wdx.1_Nonsense_Mutation_p.R280*|CSNK2A1_uc002wdy.1_Nonsense_Mutation_p.R144*	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	280	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CGTTCCCATCGCTTTCGAGAG	0.507													5	61					0	0	0	0	A	468206	A	A	468206	4	1	167	1	0	0	0	0	0	1	0	0	3974	1095	38	1	349	1	CSNK2A1	20	468206	Nonsense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08		468206	62557314	134	31534											
SLC4A11	83959	broad.mit.edu	37	chr20	3209061	3209061	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctccggatgtagtgtgtcGgggggtacgcagtctgtggg	4	10	18	9	3	1	0	0	0	1	0	3	1	2	1	2	5	1	3	2	5	2	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:3209061G>A	uc002wig.2	-	18	2498	c.2450C>T	c.(2449-2451)CCG>CTG	p.P817L	SLC4A11_uc010zqe.1_Missense_Mutation_p.P844L|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.P801L	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	817	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						GTAGTGTGTCGGGGGGTACGC	0.672													16	97					0	0	0	0	A	3209061	A	A	3209061	3	1	167	1	0	0	0	0	1	0	0	0	14716	1116	39	1	233	1	SLC4A11	20	3209061	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	2740855	3209061	59816459	135	31535											
C20orf132	140699	broad.mit.edu	37	chr20	35783534	35783534	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccgtggcccgttcccgctCatggtctttgactgactgta	4	12	12	13	3	2	2	1	2	1	0	3	2	3	2	3	3	0	3	3	3	1	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:35783534C>G	uc010zvu.1	-	11	1127	c.1036G>C	c.(1036-1038)GAG>CAG	p.E346Q	C20orf132_uc002xgk.2_Intron|C20orf132_uc002xgm.2_Missense_Mutation_p.E346Q|C20orf132_uc002xgn.2_Intron	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Myeloproliferative disorder(115;0.00878)				CGTTCCCGCTCATGGTCTTTG	0.498													26	97					0	0	0	0	G	35783534	G	G	35783534	3	3	167	1	0	0	0	0	1	0	0	0	2096	835	29	2	2198	2	C20orf132	20	35783534	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	32574473	35783534	27241986	136	31536											
PTPRT	11122	broad.mit.edu	37	chr20	41100954	41100954	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgctctccattcggccctCggggttagacagcaagagtc	7	9	11	14	3	1	2	0	0	1	2	6	2	1	2	2	3	1	3	2	3	2	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:41100954C>T	uc002xkg.2	-	8	1586	c.1402G>A	c.(1402-1404)GAG>AAG	p.E468K	PTPRT_uc010ggj.2_Missense_Mutation_p.E468K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	468	Extracellular (Potential).|Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATTCGGCCCTCGGGGTTAGAC	0.592													20	60					0	0	0	0	T	41100954	T	T	41100954	3	4	167	1	0	0	0	0	1	0	0	0	12877	893	31	1	3080	1	PTPRT	20	41100954	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	5317420	41100954	21924566	137	31537											
ELMO2	63916	broad.mit.edu	37	chr20	45000318	45000318	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggatctcgggctggatcttCtccctcagctccctggggtg	4	11	13	13	1	4	0	1	0	3	0	7	2	5	2	2	5	1	2	2	5	0	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:45000318C>G	uc002xrt.1	-	18	1803	c.1593G>C	c.(1591-1593)GAG>GAC	p.E531D	ELMO2_uc010zxq.1_Missense_Mutation_p.E263D|ELMO2_uc002xrs.1_Missense_Mutation_p.E278D|ELMO2_uc002xru.1_Missense_Mutation_p.E531D|ELMO2_uc010zxr.1_Missense_Mutation_p.E543D|ELMO2_uc010zxs.1_Missense_Mutation_p.E348D|ELMO2_uc002xrv.1_Missense_Mutation_p.E250D	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	531					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GCTGGATCTTCTCCCTCAGCT	0.617													8	37					0	0	0	0	G	45000318	G	G	45000318	3	3	167	1	0	0	0	0	1	0	0	0	5090	912	32	2	589	2	ELMO2	20	45000318	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	3899364	45000318	18025202	138	31538											
PREX1	57580	broad.mit.edu	37	chr20	47274751	47274751	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatgtcaaagccatagtcctCctcctggggcaggatctggg	8	9	13	11	0	2	0	1	0	1	0	5	2	5	1	4	4	1	1	4	4	2	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:47274751C>T	uc002xtw.1	-	17	1920	c.1897G>A	c.(1897-1899)GAG>AAG	p.E633K	PREX1_uc002xtv.1_5'Flank	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	633	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCATAGTCCTCCTCCTGGGGC	0.672											OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	206					0	0	0	0	T	47274751	T	T	47274751	3	4	167	1	0	0	0	0	1	0	0	0	12538	864	30	2	3178	2	PREX1	20	47274751	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	2274433	47274751	15750769	139	31539											
MYT1	4661	broad.mit.edu	37	chr20	62839693	62839693	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggggaaacctgggcctcctgGagcaggccatcgccctgaag	8	5	15	13	1	0	1	0	1	0	0	2	3	1	3	5	5	2	1	5	5	2	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr20:62839693G>C	uc002yii.2	+	7	1508	c.1144G>C	c.(1144-1146)GAG>CAG	p.E382Q	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_Missense_Mutation_p.E14Q	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	382					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GGGCCTCCTGGAGCAGGCCAT	0.647													11	50					0	0	0	0	C	62839693	C	C	62839693	3	2	167	1	0	0	0	0	1	0	0	0	10159	1175	41	2	1162	2	MYT1	20	62839693	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	15564942	62839693	185827	140	31540											
PKNOX1	5316	broad.mit.edu	37	chr21	44450050	44450050	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatgaacgtggacagccttCagtctctgtcctcggacggg	8	9	12	12	3	2	1	1	1	1	0	5	3	3	3	2	3	2	0	2	3	1	1			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr21:44450050C>T	uc002zcq.1	+	11	1338	c.1150C>T	c.(1150-1152)CAG>TAG	p.Q384*	PKNOX1_uc011aex.1_Nonsense_Mutation_p.Q267*	NM_004571	NP_004562	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1	384							sequence-specific DNA binding			large_intestine(2)	2						GGACAGCCTTCAGTCTCTGTC	0.567													18	87					0	0	0	0	T	44450050	T	T	44450050	4	4	167	1	0	0	0	0	0	1	0	0	12037	827	29	2	1188	2	PKNOX1	21	44450050	Nonsense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08		44450050	3679845	141	31541											
MN1	4330	broad.mit.edu	37	chr22	28193511	28193511	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccccttcccccaggatggCgacgtgagcgccttttcgtg	4	9	12	16	4	0	1	0	1	0	0	2	3	1	2	5	2	1	0	5	2	0	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chr22:28193511C>T	uc003adj.2	-	1	3976	c.3021G>A	c.(3019-3021)TCG>TCA	p.S1007S		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1007							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						CCCAGGATGGCGACGTGAGCG	0.697			T	ETV6	AML|meningioma								15	58					0	0	0	0	T	28193511	T	T	28193511	2	4	167	1	0	0	0	0	0	0	0	1	9726	755	27	1		1	MN1	22	28193511	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08		28193511	23111055	142	31542											
EGFL6	25975	broad.mit.edu	37	chrX	13645320	13645320	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacaatgccctggcatgggaGaagaccacgagtgaggatga	14	5	14	8	1	0	4	0	2	0	2	0	7	0	5	2	3	2	1	2	3	3	0			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:13645320G>A	uc004cvi.2	+	11	1716	c.1476G>A	c.(1474-1476)GAG>GAA	p.E492E	EGFL6_uc004cvj.2_Silent_p.E493E	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	492	MAM.				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						TGGCATGGGAGAAGACCACGA	0.433													6	58					0	0	0	0	A	13645320	A	A	13645320	2	1	167	1	0	0	0	0	0	0	0	1	4985	933	33	2		2	EGFL6	23	13645320	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08		13645320	141625240	143	31543											
ZMYM3	9203	broad.mit.edu	37	chrX	70470533	70470533	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcacaaagtcctcatcattGgggtcatctaccatggcatc	10	10	9	12	0	4	0	3	0	1	0	6	0	5	0	2	4	1	2	2	4	2	2			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:70470533G>A	uc004dzh.1	-	5	909	c.822C>T	c.(820-822)CCC>CCT	p.P274P	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.P274P|ZMYM3_uc004dzj.1_Silent_p.P274P|ZMYM3_uc011mpu.1_Silent_p.P5P|ZMYM3_uc004dzk.3_Silent_p.P274P|ZMYM3_uc004dzl.3_Silent_p.P274P|ZMYM3_uc004dzm.3_Silent_p.P274P	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	274					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CCTCATCATTGGGGTCATCTA	0.572													4	3					0	0	0	0	A	70470533	A	A	70470533	2	1	167	1	0	0	0	0	0	0	0	1	17768	1335	47	4		4	ZMYM3	23	70470533	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	56825213	70470533	84800027	144	31544											
PCDH19	57526	broad.mit.edu	37	chrX	99657583	99657583	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggcccctggctgttgaaaGagtgatggtagatgtggtta	8	11	17	5	0	0	4	0	2	0	2	0	4	0	4	2	5	0	4	2	5	3	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:99657583G>C	uc010nmz.2	-	3	4231	c.2555C>G	c.(2554-2556)TCT>TGT	p.S852C	PCDH19_uc004efw.3_Missense_Mutation_p.S805C|PCDH19_uc004efx.3_Missense_Mutation_p.S805C	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	852	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GCTGTTGAAAGAGTGATGGTA	0.577													3	9					0	0	0	0	C	99657583	C	C	99657583	3	2	167	1	0	0	0	0	1	0	0	0	11568	942	33	2	907	2	PCDH19	23	99657583	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	29187050	99657583	55612977	145	31545											
BEX4	56271	broad.mit.edu	37	chrX	102471381	102471381	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	actagggaacagcagatgagGcactatatgcgcttccaaac	14	7	10	10	1	0	2	0	1	0	1	1	3	1	3	1	2	4	3	1	2	5	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:102471381G>A	uc004ejv.3	+	3	535	c.300G>A	c.(298-300)AGG>AGA	p.R100R	BEX4_uc004ejw.3_Silent_p.R100R	NM_001080425	NP_001073894	Q9NWD9	BEX4_HUMAN	BEX family member 4	100						cytoplasm|nucleus				skin(1)	1						AGCAGATGAGGCACTATATGC	0.418													6	59					0	0	0	0	A	102471381	A	A	102471381	2	1	167	1	0	0	0	0	0	0	0	1	1415	1194	42	4		4	BEX4	23	102471381	Silent	SNP	G	TCGA-CR-7404-01A-11D-2129-08	2813798	102471381	52799179	146	31546											
GUCY2F	2986	broad.mit.edu	37	chrX	108691319	108691319	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttactgccaaagtggggattGataaacgttacatcctccaa	13	11	8	9	1	0	1	0	1	0	0	2	2	2	2	3	2	4	1	3	2	6	4			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:108691319G>C	uc004eod.3	-	6	1824	c.1548C>G	c.(1546-1548)ATC>ATG	p.I516M	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	516	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						AGTGGGGATTGATAAACGTTA	0.279													14	24					0	0	0	0	C	108691319	C	C	108691319	3	2	167	1	0	0	0	0	1	0	0	0	6937	1280	45	2	1834	2	GUCY2F	23	108691319	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	6219938	108691319	46579241	147	31547											
PGRMC1	10857	broad.mit.edu	37	chrX	118370416	118370416	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagattttcacgtcgccgctCaacctgctgctgcttggcct	5	12	10	14	3	2	1	2	0	0	1	3	2	2	1	3	1	4	4	3	1	1	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:118370416C>T	uc004erb.2	+	1	206	c.90C>T	c.(88-90)CTC>CTT	p.L30L	PGRMC1_uc011mts.1_Silent_p.L30L	NM_006667	NP_006658	O00264	PGRC1_HUMAN	progesterone receptor membrane component 1	30	Helical; (Potential).					cell surface|endoplasmic reticulum membrane|integral to membrane|microsome|nucleolus	heme binding|protein binding|receptor activity|steroid binding				0						CGTCGCCGCTCAACCTGCTGC	0.667													11	4					0	0	0	0	T	118370416	T	T	118370416	2	4	167	1	0	0	0	0	0	0	0	1	11861	813	29	2		2	PGRMC1	23	118370416	Silent	SNP	C	TCGA-CR-7404-01A-11D-2129-08	9679097	118370416	36900144	148	31548											
CXorf66	347487	broad.mit.edu	37	chrX	139038791	139038792	+	Missense_Mutation	DNP	TC	AA	AA																															tcgatgaatcagatgacttgTctgcagtagatagcatgggt																										TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:139038791_139038792TC>AA	uc004fbb.2	-	3	371_372	c.349_350GA>TT	c.(349-351)GAC>TTC	p.D117F		NM_001013403	NP_001013421	Q5JRM2	CX066_HUMAN	hypothetical protein LOC347487 precursor	117	Ser-rich.|Cytoplasmic (Potential).					integral to membrane					0						AGATGACTTGTCTGCAGTAGAT	0.441													10	60					0	0	0	0	AA	139038792	AA	AA	139038791	3	1	167	1	0	0	0	0	1	0	0	0	4135	1667	58	5	739	5	CXorf66	23	139038791	Missense_Mutation	DNP	TC	TCGA-CR-7404-01A-11D-2129-08	20668375	139038791	16231769	149	31549											
SLITRK4	139065	broad.mit.edu	37	chrX	142716823	142716823	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagtttctgactctttcaagCcacaagtgtggctcttgctc	7	14	8	12	0	4	1	1	1	3	0	5	1	4	1	1	1	2	3	1	1	2	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:142716823C>A	uc004fbx.2	-	2	2478	c.2102G>T	c.(2101-2103)GGC>GTC	p.G701V	SLITRK4_uc004fby.2_Missense_Mutation_p.G701V	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	701	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTCTTTCAAGCCACAAGTGTG	0.403													22	67					2.89027e-11	3.20587e-11	1	0	A	142716823	A	A	142716823	3	1	167	1	0	0	0	0	1	0	0	0	14809	739	26	4	415	4	SLITRK4	23	142716823	Missense_Mutation	SNP	C	TCGA-CR-7404-01A-11D-2129-08	3678032	142716823	12553737	150	31550											
PLXNB3	5365	broad.mit.edu	37	chrX	153043515	153043515	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatcgcccagaccttcattGactcctgtaccacctcggag	8	10	7	16	2	2	2	2	1	0	1	5	3	3	3	5	1	1	1	5	1	1	3			TCGA-CR-7404-01A-11D-2129-08	TCGA-CR-7404-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c1a8920-9163-4d56-a982-61c4e792cee7	3e2ad549-5764-4780-a8f5-22d2a57c5e8f	g.chrX:153043515G>A	uc004fii.2	+	32	5548	c.5374G>A	c.(5374-5376)GAC>AAC	p.D1792N	PLXNB3_uc010nuk.2_Missense_Mutation_p.D1815N|PLXNB3_uc011mzd.1_Missense_Mutation_p.D1431N|SRPK3_uc004fik.2_5'UTR|SRPK3_uc010nul.2_5'Flank|SRPK3_uc004fin.2_5'Flank|SRPK3_uc004fil.2_5'Flank|SRPK3_uc004fim.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1792	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GACCTTCATTGACTCCTGTAC	0.572													13	18					0	0	0	0	A	153043515	A	A	153043515	3	1	167	1	0	0	0	0	1	0	0	0	12180	1290	45	2	5614	2	PLXNB3	23	153043515	Missense_Mutation	SNP	G	TCGA-CR-7404-01A-11D-2129-08	10326692	153043515	2227045	151	31551											
GRIK3	2899	broad.mit.edu	37	chr1	37337827	37337827	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgccatagtgtggctgcagtCgaagataatgcggaattccc	10	9	12	10	3	0	1	0	0	0	1	2	3	1	2	2	2	2	2	2	2	4	3	rs143358361		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:37337827C>T	uc001caz.2	-	4	829	c.694G>A	c.(694-696)GAC>AAC	p.D232N	GRIK3_uc001cba.1_Missense_Mutation_p.D232N	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	232	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity	p.D232N(1)		ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGGCTGCAGTCGAAGATAATG	0.612													4	22					0	0	0	0	T	37337827	T	T	37337827	3	4	168	1	0	0	0	0	1	0	0	0	6814	884	31	1	2117	1	GRIK3	1	37337827	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08		37337827	211912794	1	31552											
MACF1	23499	broad.mit.edu	37	chr1	39797559	39797559	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggtcactgtccggttgctgGaagctcagctttttgctggt	5	14	13	9	1	2	0	2	0	0	0	3	1	3	1	1	4	4	5	1	4	1	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:39797559G>A	uc010oiu.1	+	1	750	c.619G>A	c.(619-621)GAA>AAA	p.E207K	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1772	Plectin 3.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCGGTTGCTGGAAGCTCAGCT	0.498													11	35					0	0	0	0	A	39797559	A	A	39797559	3	1	168	1	0	0	0	0	1	0	0	0	9195	1175	41	2	5390	2	MACF1	1	39797559	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	2459732	39797559	209453062	2	31553											
FOXE3	2301	broad.mit.edu	37	chr1	47882290	47882290	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccgccatctaccgcttcatCaccgaacgctttgccttcta	7	11	6	17	4	4	0	2	0	2	0	4	1	4	0	5	0	3	2	5	0	3	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:47882290C>T	uc001crk.2	+	1	547	c.303C>T	c.(301-303)ATC>ATT	p.I101I		NM_012186	NP_036318	Q13461	FOXE3_HUMAN	forkhead box E3	101	Fork-head.				cell migration|embryonic organ morphogenesis|enteric nervous system development|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|pattern specification process|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		ACCGCTTCATCACCGAACGCT	0.667													9	20					0	0	0	0	T	47882290	T	T	47882290	2	4	168	1	0	0	0	0	0	0	0	1	6038	816	29	2		2	FOXE3	1	47882290	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	8084731	47882290	201368331	3	31554											
WDR47	22911	broad.mit.edu	37	chr1	109554140	109554140	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttagcttcctatcagcaggGatgaattctgcaaccatgac	11	11	8	11	0	2	2	1	2	1	0	3	3	3	3	2	1	4	3	2	1	4	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:109554140G>T	uc001dwj.2	-	5	904	c.528C>A	c.(526-528)ATC>ATA	p.I176I	WDR47_uc001dwl.2_Silent_p.I183I|WDR47_uc001dwi.2_Silent_p.I176I|WDR47_uc001dwk.2_Silent_p.I148I|WDR47_uc010ovf.1_Silent_p.I103I	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	176										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		TATCAGCAGGGATGAATTCTG	0.443													42	100					6.45866e-13	7.38132e-13	1	0	T	109554140	T	T	109554140	2	4	168	1	0	0	0	0	0	0	0	1	17368	1164	41	2		2	WDR47	1	109554140	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	61671850	109554140	139696481	4	31555											
CD58	965	broad.mit.edu	37	chr1	117087209	117087209	+	Frame_Shift_Del	DEL	A	-	-																															aacaccatatatttgttgggAaaaacagctgatgaaaccta																										TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:117087209delA	uc001egm.2	-	2	209	c.88delT	c.(88-90)TCCfs	p.S30fs	CD58_uc001egn.2_RNA|CD58_uc010owy.1_Frame_Shift_Del_p.S30fs|CD58_uc001ego.1_RNA|CD58_uc001egp.3_Frame_Shift_Del_p.S30fs	NM_001779	NP_001770	P19256	LFA3_HUMAN	CD58 molecule isoform 1	30	Extracellular (Potential).				blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding				0	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		ATTTGTTGGGAAAAACAGCTG	0.343													---	---	---								-	117087209	-	-	117087209	7	5	168	1	0	1	0	1	0	0	0	0	3040	246	9	0	688	0	CD58	1	117087209	Frame_Shift_Del	DEL	A	TCGA-CV-5430-01A-02D-1683-08	7533069	117087209	132163412	5	31556											
PDE4DIP	9659	broad.mit.edu	37	chr1	144994620	144994623	+	Frame_Shift_Del	DEL	CATA	-	-																															gatgtcctcccggctggcctCatacttctgttgcatgcgct																								rs149688356	byFrequency	TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:144994620_144994623delCATA	uc001elw.3	-	1	400_403	c.109_112delTATG	c.(109-114)TATGAGfs	p.Y37fs	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Frame_Shift_Del_p.Y37fs|PDE4DIP_uc001ell.1_Frame_Shift_Del_p.Y40fs|PDE4DIP_uc001elm.3_Frame_Shift_Del_p.Y5fs|PDE4DIP_uc001eln.3_Frame_Shift_Del_p.Y103fs|PDE4DIP_uc001elo.2_Frame_Shift_Del_p.Y174fs|PDE4DIP_uc001elx.3_Frame_Shift_Del_p.Y103fs|PDE4DIP_uc001emc.1_Frame_Shift_Del_p.Y37fs|PDE4DIP_uc001emd.1_Frame_Shift_Del_p.Y37fs|PDE4DIP_uc001emg.1_Frame_Shift_Del_p.Y37fs|PDE4DIP_uc001emh.2_Frame_Shift_Del_p.Y174fs	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	37_38					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CGGCTGGCCTCATACTTCTGTTGC	0.608			T	PDGFRB	MPD								---	---	---								-	144994623	-	-	144994620	7	5	168	1	0	1	0	1	0	0	0	0	11697	835	29	0	8247	0	PDE4DIP	1	144994620	Frame_Shift_Del	DEL	CATA	TCGA-CV-5430-01A-02D-1683-08	27907411	144994620	104256001	6	31557											
NUP210L	91181	broad.mit.edu	37	chr1	154067493	154067493	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcagccacacttgtgctattCcaatcttctctgtcttctcc	6	15	5	15	0	4	0	0	0	4	0	7	0	5	0	3	0	2	2	3	0	2	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:154067493C>G	uc001fdw.2	-	15	2177	c.2105G>C	c.(2104-2106)GGA>GCA	p.G702A	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.G702A	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	702						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TTGTGCTATTCCAATCTTCTC	0.443													10	28					0	0	0	0	G	154067493	G	G	154067493	3	3	168	1	0	0	0	0	1	0	0	0	10815	855	30	2	3665	2	NUP210L	1	154067493	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	9072873	154067493	95183128	7	31558											
C1orf189	388701	broad.mit.edu	37	chr1	154171936	154171936	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acataaaaagctttgcccatCtgatttagttcctgctggta	11	14	7	9	0	1	1	0	1	1	0	2	1	2	1	2	1	3	4	2	1	5	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:154171936C>G	uc001fee.1	-	4	299	c.273G>C	c.(271-273)CAG>CAC	p.Q91H		NM_001010979	NP_001010979	Q5VU69	CA189_HUMAN	hypothetical protein LOC388701	91											0	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					CTTTGCCCATCTGATTTAGTT	0.478													42	221					0	0	0	0	G	154171936	G	G	154171936	3	3	168	1	0	0	0	0	1	0	0	0	2031	912	32	2	36	2	C1orf189	1	154171936	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	104443	154171936	95078685	8	31559											
PEAR1	375033	broad.mit.edu	37	chr1	156884446	156884446	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatgtttccagaccgagaCtctgtgggctcccagccccc	6	9	9	17	1	2	2	1	0	1	2	4	3	4	2	5	1	1	2	5	1	0	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:156884446C>T	uc001fqj.1	+	23	3086	c.2970C>T	c.(2968-2970)GAC>GAT	p.D990D	PEAR1_uc001fqk.1_Silent_p.D615D	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	990	Pro-rich.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CAGACCGAGACTCTGTGGGCT	0.607													22	65					0	0	0	0	T	156884446	T	T	156884446	2	4	168	1	0	0	0	0	0	0	0	1	11766	564	20	4		4	PEAR1	1	156884446	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	2712510	156884446	92366175	9	31560											
FCRL3	115352	broad.mit.edu	37	chr1	157666929	157666929	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagccccttagacactcaCtctgtacacgtatctgagat	11	10	7	13	1	3	2	1	1	2	2	3	3	3	2	2	0	3	3	2	0	3	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:157666929C>G	uc001frb.2	-	6	1136	c.844_splice	c.e6+1	p.R282_splice	FCRL3_uc001fqx.3_Splice_Site|FCRL3_uc001fqy.3_Splice_Site|FCRL3_uc001fqz.3_Splice_Site_p.R282_splice|FCRL3_uc009wsn.2_Intron|FCRL3_uc009wso.2_Splice_Site|FCRL3_uc001fra.2_5'UTR|FCRL3_uc001frc.1_Splice_Site_p.R282_splice	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor							integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TAGACACTCACTCTGTACACG	0.522													17	24					0	0	0	0	G	157666929	G	G	157666929	5	3	168	1	0	0	0	0	0	0	1	0	5828	579	20	4	1399	4	FCRL3	1	157666929	Splice_Site	SNP	C	TCGA-CV-5430-01A-02D-1683-08	782483	157666929	91583692	10	31561											
FCGR3A	2214	broad.mit.edu	37	chr1	161518211	161518211	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccccttcatcaactcacCgatatggacttctagctgca	9	12	5	15	1	4	0	3	0	1	0	5	2	5	1	3	1	3	2	3	1	3	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:161518211C>T	uc001gat.3	-	4	456	c.319G>A	c.(319-321)GGC>AGC	p.G107S	FCGR3A_uc001gar.2_Missense_Mutation_p.G143S|FCGR3A_uc001gas.2_Missense_Mutation_p.G142S|FCGR3A_uc009wuh.2_Missense_Mutation_p.G106S|FCGR3A_uc009wui.2_Missense_Mutation_p.G107S	NM_001127595	NP_001121067	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor	107	Extracellular (Potential).|Ig-like C2-type 2.				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATCAACTCACCGATATGGACT	0.473													4	59					0	0	0	0	T	161518211	T	T	161518211	3	4	168	1	0	0	0	0	1	0	0	0	5816	666	23	1	457	1	FCGR3A	1	161518211	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	3851282	161518211	87732410	11	31562											
FCGR3B	2215	broad.mit.edu	37	chr1	161599568	161599568	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccccttcatcaactcacCgatatggacttctagctgca	9	12	5	15	1	4	0	3	0	1	0	5	2	5	1	3	1	3	2	3	1	3	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:161599568C>T	uc009wul.2	-	3	593	c.319G>A	c.(319-321)GGC>AGC	p.G107S		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	107					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATCAACTCACCGATATGGACT	0.468													6	40					0	0	0	0	T	161599568	T	T	161599568	3	4	168	1	0	0	0	0	1	0	0	0	5817	666	23	1	394	1	FCGR3B	1	161599568	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	81357	161599568	87651053	12	31563											
MPZL1	9019	broad.mit.edu	37	chr1	167757121	167757121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtgacaagattaacaagtCagagtctgtggtgtatgcgg	12	10	13	6	1	2	3	1	1	1	2	2	3	2	3	0	2	2	1	0	2	4	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:167757121C>T	uc001geo.2	+	6	975	c.773C>T	c.(772-774)TCA>TTA	p.S258L	MPZL1_uc001gep.2_3'UTR|MPZL1_uc001geq.2_Missense_Mutation_p.S108L|MPZL1_uc009wvh.2_RNA	NM_003953	NP_003944	O95297	MPZL1_HUMAN	myelin protein zero-like 1 isoform a	258	Cytoplasmic (Potential).				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			ovary(2)	2	all_hematologic(923;0.215)					ATTAACAAGTCAGAGTCTGTG	0.438													24	30					0	0	0	0	T	167757121	T	T	167757121	3	4	168	1	0	0	0	0	1	0	0	0	9802	838	29	2	795	2	MPZL1	1	167757121	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	6157553	167757121	81493500	13	31564											
BAT2L2	23215	broad.mit.edu	37	chr1	171509614	171509614	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacgaccaagctctaacagAagggaagaagttaatgatag	17	6	10	8	1	1	3	0	1	1	2	1	5	1	4	2	1	2	2	2	1	7	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:171509614A>G	uc010pmg.1	+	16	3269	c.3003A>G	c.(3001-3003)AGA>AGG	p.R1001R	BAT2L2_uc010pmh.1_5'UTR	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1001							protein C-terminus binding				0						GCTCTAACAGAAGGGAAGAAG	0.403													6	14					0	0	0	0	G	171509614	G	G	171509614	2	3	168	1	0	0	0	0	0	0	0	1	1323	243	9	5		5	BAT2L2	1	171509614	Silent	SNP	A	TCGA-CV-5430-01A-02D-1683-08	3752493	171509614	77741007	14	31565											
CACYBP	27101	broad.mit.edu	37	chr1	174977767	174977767	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagactgatacagttcttaTattgtgtagaaagaaagtgg	15	12	10	4	0	1	4	0	1	1	3	1	4	1	4	0	1	1	2	0	1	7	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:174977767T>C	uc001gkj.1	+	5	880	c.455T>C	c.(454-456)ATA>ACA	p.I152T	CACYBP_uc001gki.1_Missense_Mutation_p.I109T	NM_014412	NP_055227	Q9HB71	CYBP_HUMAN	calcyclin binding protein isoform 1	152	Interaction with SKP1.|CS.					beta-catenin destruction complex	protein homodimerization activity				0						ACAGTTCTTATATTGTGTAGA	0.333													51	36					0	0	0	0	C	174977767	C	C	174977767	3	2	168	1	0	0	0	0	1	0	0	0	2576	1406	49	5	473	5	CACYBP	1	174977767	Missense_Mutation	SNP	T	TCGA-CV-5430-01A-02D-1683-08	3468153	174977767	74272854	15	31566											
PAPPA2	60676	broad.mit.edu	37	chr1	176668354	176668354	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaggctgtagcttggagctGctcttccaacacccggtcca	8	9	11	13	1	1	0	0	0	1	0	3	2	3	1	3	3	4	5	3	3	3	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:176668354G>T	uc001gkz.2	+	8	4029	c.2865G>T	c.(2863-2865)CTG>CTT	p.L955L	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	955					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCTTGGAGCTGCTCTTCCAAC	0.592													25	126					2.79863e-10	3.13447e-10	1	0	T	176668354	T	T	176668354	2	4	168	1	0	0	0	0	0	0	0	1	11487	1306	46	4		4	PAPPA2	1	176668354	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	1690587	176668354	72582267	16	31567											
PAPPA2	60676	broad.mit.edu	37	chr1	176769219	176769219	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgtgtgcactggccggcGtcaatggcacccagaccccg	7	7	12	15	3	1	1	1	0	0	1	1	1	1	1	4	3	1	2	4	3	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:176769219G>A	uc001gkz.2	+	21	6317	c.5153G>A	c.(5152-5154)CGT>CAT	p.R1718H	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1718	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ACTGGCCGGCGTCAATGGCAC	0.493													25	86					0	0	0	0	A	176769219	A	A	176769219	3	1	168	1	0	0	0	0	1	0	0	0	11487	1145	40	1	5284	1	PAPPA2	1	176769219	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	100865	176769219	72481402	17	31568											
QSOX1	5768	broad.mit.edu	37	chr1	180165521	180165521	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagccaccctcaacttcctCaaggcccacttctccccaag	10	7	5	19	0	3	0	2	0	1	0	5	1	4	0	6	1	2	0	6	1	4	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:180165521C>G	uc001gnz.2	+	12	1668	c.1593C>G	c.(1591-1593)CTC>CTG	p.L531L	QSOX1_uc001gny.2_Silent_p.L531L|QSOX1_uc001goa.2_Silent_p.L531L|QSOX1_uc001goc.2_Silent_p.L73L|FLJ23867_uc001god.3_5'Flank	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	531					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						TCAACTTCCTCAAGGCCCACT	0.617													62	140					0	0	0	0	G	180165521	G	G	180165521	2	3	168	1	0	0	0	0	0	0	0	1	12948	813	29	2		2	QSOX1	1	180165521	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	3396302	180165521	69085100	18	31569											
ASPM	259266	broad.mit.edu	37	chr1	197071233	197071233	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacagcagagtgtctttgtCtgagataatgctgcctctgc	8	13	10	10	0	4	2	1	1	3	2	4	3	4	2	1	0	4	2	1	0	1	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:197071233C>G	uc001gtu.2	-	18	7405	c.7148G>C	c.(7147-7149)AGA>ACA	p.R2383T	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.R231T	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2383					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GTGTCTTTGTCTGAGATAATG	0.433													37	151					0	0	0	0	G	197071233	G	G	197071233	3	3	168	1	0	0	0	0	1	0	0	0	1058	913	32	2	3329	2	ASPM	1	197071233	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	16905712	197071233	52179388	19	31570											
PTPN14	5784	broad.mit.edu	37	chr1	214542824	214542824	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaatccttggacatcttctgGacagccgtgatctggccagt	9	11	10	11	1	3	1	0	1	3	0	4	3	4	3	3	3	1	0	3	3	1	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:214542824G>C	uc001hkk.1	-	17	3518	c.3247C>G	c.(3247-3249)CCA>GCA	p.P1083A		NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	1083	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		ACATCTTCTGGACAGCCGTGA	0.438													37	74					0	0	0	0	C	214542824	C	C	214542824	3	2	168	1	0	0	0	0	1	0	0	0	12846	1174	41	2	328	2	PTPN14	1	214542824	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	17471591	214542824	34707797	20	31571											
USH2A	7399	broad.mit.edu	37	chr1	215848775	215848775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacagagtggacagtaggagCcagctgagagtctggagggg	11	5	18	7	0	1	2	0	1	1	2	1	6	1	5	1	5	2	2	1	5	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:215848775C>T	uc001hku.1	-	63	12865	c.12478G>A	c.(12478-12480)GCT>ACT	p.A4160T		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4160	Extracellular (Potential).|Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAGTAGGAGCCAGCTGAGAG	0.542										HNSCC(13;0.011)			12	46					0	0	0	0	T	215848775	T	T	215848775	3	4	168	1	0	0	0	0	1	0	0	0	17104	739	26	4	3170	4	USH2A	1	215848775	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	1305951	215848775	33401846	21	31572											
OBSCN	84033	broad.mit.edu	37	chr1	228509058	228509058	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccacaggttggggccccagCagccccctctgtgaagccac	7	5	11	18	0	1	1	0	1	1	0	1	1	1	1	6	3	3	2	6	3	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr1:228509058C>A	uc009xez.1	+	55	14560	c.14516C>A	c.(14515-14517)GCA>GAA	p.A4839E	OBSCN_uc001hsn.2_Missense_Mutation_p.A4839E	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4839					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGGGCCCCAGCAGCCCCCTCT	0.622													8	25					3.09899e-07	3.36977e-07	1	0	A	228509058	A	A	228509058	3	1	168	1	0	0	0	0	1	0	0	0	10866	710	25	4	14730	4	OBSCN	1	228509058	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	12660283	228509058	20741563	22	31573											
ADAM17	6868	broad.mit.edu	37	chr2	9666273	9666273	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtactctcttcccctctGcccatgtatctgtagaagcg	6	14	8	13	1	3	1	0	0	3	1	5	1	4	1	3	0	3	4	3	0	4	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:9666273G>A	uc002qzu.2	-	6	903	c.720C>T	c.(718-720)GGC>GGT	p.G240G	ADAM17_uc010ewy.2_Silent_p.G240G|ADAM17_uc010ewz.2_Intron|ADAM17_uc010exa.2_5'Flank	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	240	Peptidase M12B.|Extracellular (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		CTTCCCCTCTGCCCATGTATC	0.383													66	111					0	0	0	0	A	9666273	A	A	9666273	2	1	168	1	0	0	0	0	0	0	0	1	238	1306	46	4		4	ADAM17	2	9666273	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08		9666273	233533100	23	31574											
GTF3C2	2976	broad.mit.edu	37	chr2	27566417	27566417	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catagccgaccccgcaggtaTccatcagcaccccccaaaat	12	5	6	18	2	1	0	1	0	0	0	2	1	2	0	7	1	2	3	7	1	4	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:27566417T>A	uc002rjv.1	-	3	368	c.5A>T	c.(4-6)GAT>GTT	p.D2V	GTF3C2_uc002rju.1_Missense_Mutation_p.D13V|GTF3C2_uc002rjw.1_Missense_Mutation_p.D2V|GTF3C2_uc010eyz.1_Missense_Mutation_p.D2V	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	2						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCGCAGGTATCCATCAGCAC	0.517													39	70					0	0	0	0	A	27566417	A	A	27566417	3	1	168	1	0	0	0	0	1	0	0	0	6912	1435	50	5	2802	5	GTF3C2	2	27566417	Missense_Mutation	SNP	T	TCGA-CV-5430-01A-02D-1683-08	17900144	27566417	215632956	24	31575											
LTBP1	4052	broad.mit.edu	37	chr2	33588552	33588552	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgctactgtaagcaagggAcgtactatgatcctgtgaaa	14	10	10	7	1	0	2	0	2	0	0	1	3	1	3	1	1	4	4	1	1	7	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:33588552A>C	uc002ros.2	+	29	4369	c.4369A>C	c.(4369-4371)ACG>CCG	p.T1457P	LTBP1_uc002rot.2_Missense_Mutation_p.T1131P|LTBP1_uc002rou.2_Missense_Mutation_p.T1130P|LTBP1_uc002rov.2_Missense_Mutation_p.T1077P|LTBP1_uc010ymz.1_Missense_Mutation_p.T1088P|LTBP1_uc010yna.1_Missense_Mutation_p.T1035P|LTBP1_uc010ynb.1_Missense_Mutation_p.T354P	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1456	EGF-like 15; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TAAGCAAGGGACGTACTATGA	0.398													14	92					0	0	0	0	C	33588552	C	C	33588552	3	2	168	1	0	0	0	0	1	0	0	0	9123	275	10	5	4535	5	LTBP1	2	33588552	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	6022135	33588552	209610821	25	31576											
PSME4	23198	broad.mit.edu	37	chr2	54155437	54155437	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtctctaatgcaggataTgttctacagtttgaaaacag	14	13	8	6	0	2	1	0	1	2	0	3	2	2	2	0	1	3	3	0	1	6	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:54155437T>C	uc002rxp.2	-	11	1376	c.1320A>G	c.(1318-1320)ACA>ACG	p.T440T	PSME4_uc010yop.1_Silent_p.T326T|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_5'UTR|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	440					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ATGCAGGATATGTTCTACAGT	0.353													4	24					0	0	0	0	C	54155437	C	C	54155437	2	2	168	1	0	0	0	0	0	0	0	1	12771	1451	51	5		5	PSME4	2	54155437	Silent	SNP	T	TCGA-CV-5430-01A-02D-1683-08	20566885	54155437	189043936	26	31577											
CNNM3	26505	broad.mit.edu	37	chr2	97490833	97490833	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgtgcagaaggtgaacaacGagggtgaaggcgaccccttc	11	6	14	10	3	0	3	0	2	0	1	2	5	0	3	2	3	3	1	2	3	4	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:97490833G>A	uc002swy.2	+	2	1288	c.1264G>A	c.(1264-1266)GAG>AAG	p.E422K	CNNM3_uc002swz.2_Intron	NM_017623	NP_060093	Q8NE01	CNNM3_HUMAN	cyclin M3 isoform 1	422	CBS 2.				ion transport	integral to membrane|plasma membrane	protein binding			ovary(1)	1						GGTGAACAACGAGGGTGAAGG	0.602													6	34					0	0	0	0	A	97490833	A	A	97490833	3	1	168	1	0	0	0	0	1	0	0	0	3629	1059	37	1	1270	1	CNNM3	2	97490833	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	43335396	97490833	145708540	27	31578											
FHL2	2274	broad.mit.edu	37	chr2	105977793	105977794	+	Frame_Shift_Ins	INS	-	G	G																															tcgtccctctctgtgaggaaINSgccacgccccaccagtgaga																										TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:105977793_105977794insG	uc002tcu.2	-	6	1123_1124	c.786_787insC	c.(784-789)GGCTTCfs	p.G262fs	FHL2_uc002tdc.2_Frame_Shift_Ins_p.G148fs|FHL2_uc002tdd.2_Frame_Shift_Ins_p.G262fs|FHL2_uc002tct.2_Frame_Shift_Ins_p.G148fs|FHL2_uc002tcv.2_Frame_Shift_Ins_p.G262fs|FHL2_uc002tcw.2_Frame_Shift_Ins_p.G262fs|FHL2_uc002tcx.2_Frame_Shift_Ins_p.G262fs|FHL2_uc010fje.2_Frame_Shift_Ins_p.G175fs|FHL2_uc002tcy.2_Frame_Shift_Ins_p.G262fs|FHL2_uc002tcz.2_Frame_Shift_Ins_p.G372fs|FHL2_uc002tda.2_RNA|FHL2_uc002tdb.2_Frame_Shift_Ins_p.G378fs	NM_201557	NP_963851	Q14192	FHL2_HUMAN	four and a half LIM domains 2	262_263	LIM zinc-binding 4.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent	actin cytoskeleton|focal adhesion|nucleus	androgen receptor binding|identical protein binding|transcription coactivator activity|zinc ion binding			ovary(1)	1						TCTGTGAGGAAGCCACGCCCCA	0.5													---	---	---								G	105977794	G	G	105977793	7	5	168	1	0	1	1	0	0	0	0	0	5911	72	3	0	56	0	FHL2	2	105977793	Frame_Shift_Ins	INS	-	TCGA-CV-5430-01A-02D-1683-08	8486960	105977793	137221580	28	31579											
TNFAIP6	7130	broad.mit.edu	37	chr2	152226720	152226720	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcttggctgattatgttgAaatatatgacagttacgatg	11	16	10	4	1	0	3	0	3	0	0	0	4	0	3	0	1	2	4	0	1	5	7			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:152226720A>C	uc002txk.2	+	4	657	c.581A>C	c.(580-582)GAA>GCA	p.E194A		NM_007115	NP_009046	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	194	CUB.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		GATTATGTTGAAATATATGAC	0.413													32	166					0	0	0	0	C	152226720	C	C	152226720	3	2	168	1	0	0	0	0	1	0	0	0	16341	246	9	5	595	5	TNFAIP6	2	152226720	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	46248927	152226720	90972653	29	31580											
PKP4	8502	broad.mit.edu	37	chr2	159488376	159488376	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggggaggacctattacaGcccagtgtaccgcagcccaa	11	6	12	12	1	0	1	0	1	0	0	0	3	0	3	4	3	4	2	4	3	4	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:159488376G>T	uc002tzv.2	+	8	1525	c.1265G>T	c.(1264-1266)AGC>ATC	p.S422I	PKP4_uc002tzt.1_Missense_Mutation_p.S274I|PKP4_uc002tzu.2_Missense_Mutation_p.S422I|PKP4_uc002tzw.2_Missense_Mutation_p.S422I|PKP4_uc002tzx.2_Missense_Mutation_p.S80I|PKP4_uc002tzy.1_Missense_Mutation_p.S80I|PKP4_uc002tzz.1_Missense_Mutation_p.S420I|PKP4_uc002uaa.2_Missense_Mutation_p.S274I	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	422	ARM 1.				cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						ACCTATTACAGCCCAGTGTAC	0.527										HNSCC(62;0.18)			22	62					1.96292e-10	2.20952e-10	1	0	T	159488376	T	T	159488376	3	4	168	1	0	0	0	0	1	0	0	0	12042	971	34	4	1291	4	PKP4	2	159488376	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	7261656	159488376	83710997	30	31581											
SP3	6670	broad.mit.edu	37	chr2	174819640	174819640	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctcctggatgtagctgtaTaccagcagaatctatagagt	11	12	9	9	0	2	2	0	0	2	2	3	3	2	3	2	1	3	4	2	1	6	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:174819640T>C	uc002uig.2	-	4	1764	c.1600A>G	c.(1600-1602)ATA>GTA	p.I534V	SP3_uc002uie.2_Missense_Mutation_p.I466V|SP3_uc002uif.2_Missense_Mutation_p.I481V|SP3_uc010zel.1_Missense_Mutation_p.I531V	NM_003111	NP_003102	Q02447	SP3_HUMAN	Sp3 transcription factor isoform 1	534	Repressor domain.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	soft_tissue(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.185)			TGTAGCTGTATACCAGCAGAA	0.423													35	57					0	0	0	0	C	174819640	C	C	174819640	3	2	168	1	0	0	0	0	1	0	0	0	15029	1406	49	5	761	5	SP3	2	174819640	Missense_Mutation	SNP	T	TCGA-CV-5430-01A-02D-1683-08	15331264	174819640	68379733	31	31582											
OLA1	29789	broad.mit.edu	37	chr2	175006625	175006625	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttatctataatgggcccaatCatttcctcatctttaagctg	10	16	5	10	0	4	0	2	0	2	0	5	0	5	0	2	1	1	1	2	1	5	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:175006625C>T	uc002uih.2	-	5	663	c.477G>A	c.(475-477)ATG>ATA	p.M159I	OLA1_uc002uii.2_Missense_Mutation_p.M1I|OLA1_uc010fqq.2_Missense_Mutation_p.M159I|OLA1_uc002uij.2_Missense_Mutation_p.M1I|OLA1_uc002uik.2_Missense_Mutation_p.M129I|OLA1_uc010fqr.2_Missense_Mutation_p.M159I	NM_013341	NP_037473	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1 isoform 1	159					ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			ovary(1)|breast(1)	2						TGGGCCCAATCATTTCCTCAT	0.343													16	87					0	0	0	0	T	175006625	T	T	175006625	3	4	168	1	0	0	0	0	1	0	0	0	10904	826	29	2	741	2	OLA1	2	175006625	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	186985	175006625	68192748	32	31583											
TTC30A	92104	broad.mit.edu	37	chr2	178482633	178482633	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcttgagctacctcatagTttctcagttggtattctatg	7	19	7	8	0	4	1	2	1	3	0	5	1	4	1	1	1	2	4	1	1	4	9			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:178482633T>A	uc002ulo.2	-	1	1062	c.797A>T	c.(796-798)AAC>ATC	p.N266I		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	266					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			TACCTCATAGTTTCTCAGTTG	0.507													40	80					0	0	0	0	A	178482633	A	A	178482633	3	1	168	1	0	0	0	0	1	0	0	0	16766	1725	60	5	1204	5	TTC30A	2	178482633	Missense_Mutation	SNP	T	TCGA-CV-5430-01A-02D-1683-08	3476008	178482633	64716740	33	31584											
TTN	7273	broad.mit.edu	37	chr2	179449963	179449963	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgtgacaacttcatcttctCcttttttccatttacaggtg	8	18	5	10	0	3	1	1	1	2	0	5	1	4	1	2	1	2	0	2	1	2	7			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:179449963C>T	uc010zfg.1	-	258	57028	c.56804G>A	c.(56803-56805)GGA>GAA	p.G18935E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G12630E|TTN_uc010zfi.1_Missense_Mutation_p.G12563E|TTN_uc010zfj.1_Missense_Mutation_p.G12438E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19862							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATCTTCTCCTTTTTTCCA	0.423													32	189					0	0	0	0	T	179449963	T	T	179449963	3	4	168	1	0	0	0	0	1	0	0	0	16803	855	30	2	43687	2	TTN	2	179449963	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	967330	179449963	63749410	34	31585											
ORC2L	4999	broad.mit.edu	37	chr2	201798698	201798698	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattcttctactaagtcactCtgaaagtgaacagagtagtc	13	13	7	8	0	4	3	1	2	3	1	5	3	4	3	0	0	2	1	0	0	6	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr2:201798698C>T	uc002uwr.2	-	10	966	c.709_splice	c.e10-1	p.S237_splice	ORC2L_uc010zhj.1_Splice_Site_p.S237_splice	NM_006190	NP_006181	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2						cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0						CTAAGTCACTCTGAAAGTGAA	0.348													14	73					0	0	0	0	T	201798698	T	T	201798698	5	4	168	1	0	0	0	0	0	0	1	0	11316	927	32	2	1061	2	ORC2L	2	201798698	Splice_Site	SNP	C	TCGA-CV-5430-01A-02D-1683-08	22348735	201798698	41400675	35	31586											
CACNA1D	776	broad.mit.edu	37	chr3	53834348	53834348	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgtgatttgcaagatgacGagcctgaggaaacaaaacga	15	7	12	7	3	0	4	0	3	0	1	0	7	0	5	1	1	4	1	1	1	4	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:53834348G>T	uc003dgv.3	+	41	5159	c.4996G>T	c.(4996-4998)GAG>TAG	p.E1666*	CACNA1D_uc003dgu.3_Nonsense_Mutation_p.E1686*|CACNA1D_uc003dgy.3_Nonsense_Mutation_p.E1651*|CACNA1D_uc003dgw.3_Nonsense_Mutation_p.E1333*|CACNA1D_uc003dgx.1_Nonsense_Mutation_p.E842*|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1666	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GCAAGATGACGAGCCTGAGGA	0.463													20	45					1.33834e-09	1.4841e-09	1	0	T	53834348	T	T	53834348	4	4	168	1	0	0	0	0	0	1	0	0	2553	1059	37	3	5330	3	CACNA1D	3	53834348	Nonsense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08		53834348	144188082	36	31587											
PDE12	201626	broad.mit.edu	37	chr3	57542169	57542169	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggacggcggtggagaagctGagccgggctgaagcggggag	8	3	22	8	5	0	3	0	2	0	1	0	6	0	5	1	7	3	2	1	7	2	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:57542169G>A	uc003diw.3	+	1	189	c.63G>A	c.(61-63)CTG>CTA	p.L21L	PDE12_uc003div.2_Silent_p.L21L	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	21							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		TGGAGAAGCTGAGCCGGGCTG	0.692													5	9					0	0	0	0	A	57542169	A	A	57542169	2	1	168	1	0	0	0	0	0	0	0	1	11686	1277	45	2		2	PDE12	3	57542169	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	3707821	57542169	140480261	37	31588											
NFKBIZ	64332	broad.mit.edu	37	chr3	101573934	101573934	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaggtggcagtggctgccaAtcagcatctcattgtgcagg	8	10	13	10	0	3	0	3	0	1	0	4	0	3	0	1	4	3	4	1	4	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:101573934A>G	uc003dvp.2	+	7	1587	c.1472A>G	c.(1471-1473)AAT>AGT	p.N491S	NFKBIZ_uc003dvo.2_Missense_Mutation_p.N391S|NFKBIZ_uc010hpo.2_Missense_Mutation_p.N391S|NFKBIZ_uc003dvq.2_Missense_Mutation_p.N369S	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	491	Interaction with NFKB1/p50 (By similarity).|ANK 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						GTGGCTGCCAATCAGCATCTC	0.458													21	102					0	0	0	0	G	101573934	G	G	101573934	3	3	168	1	0	0	0	0	1	0	0	0	10437	101	4	5	1498	5	NFKBIZ	3	101573934	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	44031765	101573934	96448496	38	31589											
CD96	10225	broad.mit.edu	37	chr3	111296359	111296359	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcttccttaggaaaacagcaGcacggattcttgggtccttc	9	12	9	11	1	2	0	0	0	2	0	5	2	4	2	2	3	3	2	2	3	3	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:111296359G>C	uc003dxw.2	+	4	724	c.554G>C	c.(553-555)AGC>ACC	p.S185T	CD96_uc003dxv.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	185	Extracellular (Potential).|Ig-like V-type 2.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						GAAAACAGCAGCACGGATTCT	0.423									Opitz_Trigonocephaly_syndrome				62	331					0	0	0	0	C	111296359	C	C	111296359	3	2	168	1	0	0	0	0	1	0	0	0	3063	971	34	4	568	4	CD96	3	111296359	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	9722425	111296359	86726071	39	31590											
ATP2C1	27032	broad.mit.edu	37	chr3	130715584	130715584	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaactttcctaatcctctCaatgccatgcagattttgtg	10	15	6	10	0	1	2	1	1	1	1	4	2	3	2	3	0	3	1	3	0	3	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:130715584C>G	uc003enl.2	+	24	2409	c.2187C>G	c.(2185-2187)CTC>CTG	p.L729L	ATP2C1_uc011blg.1_Silent_p.L763L|ATP2C1_uc011blh.1_Silent_p.L724L|ATP2C1_uc011bli.1_Silent_p.L763L|ATP2C1_uc003enk.2_Silent_p.L713L|ATP2C1_uc003enm.2_Silent_p.L729L|ATP2C1_uc003enn.2_Silent_p.L713L|ATP2C1_uc003eno.2_Silent_p.L729L|ATP2C1_uc003enp.2_Silent_p.L729L|ATP2C1_uc003enq.2_Silent_p.L729L|ATP2C1_uc003enr.2_Silent_p.L729L|ATP2C1_uc003ens.2_Silent_p.L729L|ATP2C1_uc003ent.2_Silent_p.L729L|ATP2C1_uc003enu.2_Silent_p.L407L	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	729	Lumenal (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	CTAATCCTCTCAATGCCATGC	0.363									Hailey-Hailey_disease				35	85					0	0	0	0	G	130715584	G	G	130715584	2	3	168	1	0	0	0	0	0	0	0	1	1145	813	29	2		2	ATP2C1	3	130715584	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	19419225	130715584	67306846	40	31591											
NPHP3	27031	broad.mit.edu	37	chr3	132435736	132435736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctccgccagtccaatattCacattgggttccagcagctg	8	10	10	13	1	1	0	1	0	0	0	4	0	4	0	4	2	2	4	4	2	2	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:132435736C>T	uc003epe.1	-	4	765	c.688G>A	c.(688-690)GAA>AAA	p.E230K	NPHP3_uc003epf.1_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	230					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						GTCCAATATTCACATTGGGTT	0.443													15	74					0	0	0	0	T	132435736	T	T	132435736	3	4	168	1	0	0	0	0	1	0	0	0	10634	835	29	2	3400	2	NPHP3	3	132435736	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	1720152	132435736	65586694	41	31592											
KY	339855	broad.mit.edu	37	chr3	134323141	134323141	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcactgagctgtagatgtcGgagttgcccttggcaaagat	10	10	13	8	1	0	3	0	1	0	2	1	4	0	4	1	2	3	5	1	2	2	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:134323141G>A	uc010hty.2	-	11	1328	c.1266C>T	c.(1264-1266)TCC>TCT	p.S422S	KY_uc011blw.1_3'UTR|KY_uc011blx.1_Silent_p.S401S	NM_178554	NP_848649	Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	422						cytoskeleton|Z disc	peptidase activity			ovary(2)	2						TGTAGATGTCGGAGTTGCCCT	0.562													8	60					0	0	0	0	A	134323141	A	A	134323141	2	1	168	1	0	0	0	0	0	0	0	1	8626	1103	39	1		1	KY	3	134323141	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	1887405	134323141	63699289	42	31593											
AP2M1	1173	broad.mit.edu	37	chr3	183894784	183894784	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagactgatctgccgccatGattggaggcttattcatcta	9	12	11	9	1	3	3	1	2	2	1	3	5	3	4	2	3	1	1	2	3	2	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr3:183894784G>C	uc011bqx.1	+	2	160	c.3G>C	c.(1-3)ATG>ATC	p.M1I	AP2M1_uc003fmw.2_Missense_Mutation_p.M1I|AP2M1_uc003fmx.2_Missense_Mutation_p.M1I|AP2M1_uc003fmy.2_Missense_Mutation_p.M1I	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	1					axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTGCCGCCATGATTGGAGGCT	0.582													6	38					0	0	0	0	C	183894784	C	C	183894784	3	2	168	1	0	0	0	0	1	0	0	0	742	1290	45	2	5	2	AP2M1	3	183894784	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	49571643	183894784	14127646	43	31594											
DGKQ	1609	broad.mit.edu	37	chr4	959312	959312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtgactcacggacaccaCggtggctgcaaaggcaggct	10	6	14	11	2	1	1	1	1	0	0	1	3	1	2	1	5	1	4	1	5	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:959312C>T	uc003gbw.2	-	14	1659	c.1585G>A	c.(1585-1587)GTG>ATG	p.V529M	DGKQ_uc010ibn.2_Intron	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	529					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ACGGACACCACGGTGGCTGCA	0.652													3	25					0	0	0	0	T	959312	T	T	959312	3	4	168	1	0	0	0	0	1	0	0	0	4495	536	19	1	1283	1	DGKQ	4	959312	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08		959312	190194964	44	31595											
SLC2A9	56606	broad.mit.edu	37	chr4	9828063	9828063	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatcagtgacagctgagtcGattttctcttctggtgggta	7	14	11	9	1	3	2	1	2	2	0	5	3	3	2	1	2	1	2	1	2	1	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:9828063G>A	uc003gmc.2	-	12	1642	c.1581C>T	c.(1579-1581)ATC>ATT	p.I527I	SLC2A9_uc003gmd.2_Silent_p.I498I	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	527	Cytoplasmic (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						CAGCTGAGTCGATTTTCTCTT	0.423													40	77					0	0	0	0	A	9828063	A	A	9828063	2	1	168	1	0	0	0	0	0	0	0	1	14616	1048	37	1		1	SLC2A9	4	9828063	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	8868751	9828063	181326213	45	31596											
NKX3-2	579	broad.mit.edu	37	chr4	13544126	13544126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctctggggccaacaccgtCgtcctcggtccttgggctgc	4	9	12	16	3	1	0	0	0	1	0	5	0	3	0	5	4	2	1	5	4	1	1	rs61795263		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:13544126C>T	uc003gmx.2	-	2	569	c.493G>A	c.(493-495)GAC>AAC	p.D165N		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	165					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCAACACCGTCGTCCTCGGTC	0.463													4	20					0	0	0	0	T	13544126	T	T	13544126	3	4	168	1	0	0	0	0	1	0	0	0	10510	884	31	1	512	1	NKX3-2	4	13544126	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	3716063	13544126	177610150	46	31597											
PF4	5196	broad.mit.edu	37	chr4	74846999	74846999	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaattttccttccattcttCagcgtggctctggcagggaa	8	13	9	11	1	3	0	1	0	2	0	5	1	5	1	2	3	1	2	2	3	2	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:74846999C>T	uc003hhi.2	-	3	273	c.228G>A	c.(226-228)CTG>CTA	p.L76L		NM_002619	NP_002610	P02776	PLF4_HUMAN	platelet factor 4 (chemokine (C-X-C motif)	76					cytokine-mediated signaling pathway|immune response|leukocyte chemotaxis|negative regulation of angiogenesis|negative regulation of apoptosis|negative regulation of cytolysis|negative regulation of megakaryocyte differentiation|negative regulation of MHC class II biosynthetic process|platelet activation|platelet degranulation|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of tumor necrosis factor production	extracellular space|platelet alpha granule lumen	chemokine activity|heparin binding				0	Breast(15;0.00136)		all cancers(17;0.0034)|Lung(101;0.196)		Drotrecogin alfa(DB00055)	TTCCATTCTTCAGCGTGGCTC	0.488													9	87					0	0	0	0	T	74846999	T	T	74846999	2	4	168	1	0	0	0	0	0	0	0	1	11807	813	29	2		2	PF4	4	74846999	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	61302873	74846999	116307277	47	31598											
FAT1	2195	broad.mit.edu	37	chr4	187538164	187538164	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagagctgcttaccttttCacaaactggactgttgtcat	10	13	9	9	0	2	1	2	0	0	1	2	3	2	3	1	2	4	3	1	2	3	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr4:187538164C>A	uc003izf.2	-	11	9258	c.9070G>T	c.(9070-9072)GAA>TAA	p.E3024*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3024	Extracellular (Potential).|Cadherin 28.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CTTACCTTTTCACAAACTGGA	0.388										HNSCC(5;0.00058)			13	22					7.93312e-07	8.54336e-07	1	0	A	187538164	A	A	187538164	4	1	168	1	0	0	0	0	0	1	0	0	5721	835	29	2	4764	2	FAT1	4	187538164	Nonsense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	112691165	187538164	3616112	48	31599											
NUDT12	83594	broad.mit.edu	37	chr5	102894586	102894586	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattcatttcttaccagcttCtttttctttcaattgcagaa	9	19	3	10	0	5	1	2	0	3	1	5	1	5	1	1	0	3	2	1	0	3	8			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:102894586C>G	uc003koi.2	-	3	883	c.790G>C	c.(790-792)GAA>CAA	p.E264Q	NUDT12_uc011cvb.1_Missense_Mutation_p.E246Q	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	264						nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		TTACCAGCTTCTTTTTCTTTC	0.373													3	7					0	0	0	0	G	102894586	G	G	102894586	3	3	168	1	0	0	0	0	1	0	0	0	10782	922	32	2	618	2	NUDT12	5	102894586	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08		102894586	78020674	49	31600											
APC	324	broad.mit.edu	37	chr5	112176368	112176368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacgagataccattcctacaGaaggcagaagtacagatgag	17	6	10	8	1	0	5	0	1	0	4	1	6	1	5	2	1	4	2	2	1	6	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:112176368G>A	uc010jby.2	+	16	5457	c.5077G>A	c.(5077-5079)GAA>AAA	p.E1693K	APC_uc011cvt.1_Missense_Mutation_p.E1675K|APC_uc003kpz.3_Missense_Mutation_p.E1693K|APC_uc003kpy.3_Missense_Mutation_p.E1693K|APC_uc010jbz.2_Missense_Mutation_p.E1410K|APC_uc010jca.2_Missense_Mutation_p.E993K	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1693	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CATTCCTACAGAAGGCAGAAG	0.438		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			4	17					0	0	0	0	A	112176368	A	A	112176368	3	1	168	1	0	0	0	0	1	0	0	0	763	943	33	2	5135	2	APC	5	112176368	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	9281782	112176368	68738892	50	31601			1	46		4	4	2212	G		3.44477e-07
APC	324	broad.mit.edu	37	chr5	112177885	112177885	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaaagtttataaaagtttGattactggaaaagttcgatc	18	13	7	3	1	0	1	0	1	0	0	2	3	0	2	0	1	1	3	0	1	9	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:112177885G>C	uc010jby.2	+	16	6974	c.6594G>C	c.(6592-6594)TTG>TTC	p.L2198F	APC_uc011cvt.1_Missense_Mutation_p.L2180F|APC_uc003kpz.3_Missense_Mutation_p.L2198F|APC_uc003kpy.3_Missense_Mutation_p.L2198F|APC_uc010jbz.2_Missense_Mutation_p.L1915F|APC_uc010jca.2_Missense_Mutation_p.L1498F	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2198	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATAAAAGTTTGATTACTGGAA	0.358		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			13	36					0	0	0	0	C	112177885	C	C	112177885	3	2	168	1	0	0	0	0	1	0	0	0	763	1281	45	2	6652	2	APC	5	112177885	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	1517	112177885	68737375	51	31602			1	46		4	4	2212	G		3.44477e-07
APC	324	broad.mit.edu	37	chr5	112178407	112178407	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatacatctccaggtagacaGatgagccaacagaaccttac	15	8	7	11	0	1	4	0	1	1	3	2	4	1	4	3	1	5	1	3	1	6	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:112178407G>T	uc010jby.2	+	16	7496	c.7116G>T	c.(7114-7116)CAG>CAT	p.Q2372H	APC_uc011cvt.1_Missense_Mutation_p.Q2354H|APC_uc003kpz.3_Missense_Mutation_p.Q2372H|APC_uc003kpy.3_Missense_Mutation_p.Q2372H|APC_uc010jbz.2_Missense_Mutation_p.Q2089H|APC_uc010jca.2_Missense_Mutation_p.Q1672H	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2372	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CAGGTAGACAGATGAGCCAAC	0.403		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			14	34					1.5842e-08	1.74808e-08	1	0	T	112178407	T	T	112178407	3	4	168	1	0	0	0	0	1	0	0	0	763	933	33	2	7174	2	APC	5	112178407	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	522	112178407	68736853	52	31603			1	46		4	4	2212	G		3.44477e-07
APC	324	broad.mit.edu	37	chr5	112178579	112178579	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatcaagtggaagtgaatctGatagatcagaaagacctgta	17	9	10	5	0	3	5	2	2	1	3	3	6	3	6	1	1	0	1	1	1	7	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:112178579G>C	uc010jby.2	+	16	7668	c.7288G>C	c.(7288-7290)GAT>CAT	p.D2430H	APC_uc011cvt.1_Missense_Mutation_p.D2412H|APC_uc003kpz.3_Missense_Mutation_p.D2430H|APC_uc003kpy.3_Missense_Mutation_p.D2430H|APC_uc010jbz.2_Missense_Mutation_p.D2147H|APC_uc010jca.2_Missense_Mutation_p.D1730H	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2430	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AAGTGAATCTGATAGATCAGA	0.373		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			17	34					0	0	0	0	C	112178579	C	C	112178579	3	2	168	1	0	0	0	0	1	0	0	0	763	1290	45	2	7346	2	APC	5	112178579	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	172	112178579	68736681	53	31604			1	46		4	4	2212	G		3.44477e-07
PCDHB10	56126	broad.mit.edu	37	chr5	140572793	140572793	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgggtctccatccaggtCtgggacctctactgtacgca	6	11	12	12	1	3	0	0	0	3	0	5	1	4	1	3	4	2	2	3	4	2	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:140572793C>G	uc003lix.2	+	1	842	c.668C>G	c.(667-669)TCT>TGT	p.S223C		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	223	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCATCCAGGTCTGGGACCTCT	0.552													28	70					0	0	0	0	G	140572793	G	G	140572793	3	3	168	1	0	0	0	0	1	0	0	0	11589	913	32	2	670	2	PCDHB10	5	140572793	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	28394214	140572793	40342467	54	31605											
GRIA1	2890	broad.mit.edu	37	chr5	153085627	153085627	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggatgtgacatttctcccaGgtcagtcagctcttctcaat	9	13	8	11	0	5	1	3	1	3	0	7	2	5	2	1	2	1	1	1	2	1	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:153085627G>A	uc003lva.3	+	11	2188	c.1823G>A	c.(1822-1824)AGG>AAG	p.R608K	GRIA1_uc003luy.3_Missense_Mutation_p.R608K|GRIA1_uc003luz.3_Missense_Mutation_p.R513K|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.R528K|GRIA1_uc011dcx.1_Missense_Mutation_p.R539K|GRIA1_uc011dcy.1_Missense_Mutation_p.R618K|GRIA1_uc011dcz.1_Missense_Mutation_p.R618K|GRIA1_uc010jia.1_Missense_Mutation_p.R588K	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	608	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ATTTCTCCCAGGTCAGTCAGC	0.373													31	22					0	0	0	0	A	153085627	A	A	153085627	3	1	168	1	0	0	0	0	1	0	0	0	6806	1014	35	4	1865	4	GRIA1	5	153085627	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	12512834	153085627	27829633	55	31606											
WWC1	23286	broad.mit.edu	37	chr5	167887709	167887709	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaaaaagccaccttttgttCgaaactccctggagcgacgc	11	8	8	14	3	0	0	0	0	0	0	2	3	1	1	4	1	3	1	4	1	3	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:167887709C>T	uc003lzu.2	+	20	2971	c.2878C>T	c.(2878-2880)CGA>TGA	p.R960*	WWC1_uc003lzv.2_Nonsense_Mutation_p.R960*|WWC1_uc011den.1_Nonsense_Mutation_p.R960*|WWC1_uc003lzw.2_Nonsense_Mutation_p.R759*|WWC1_uc010jjf.1_Nonsense_Mutation_p.R232*	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	960	Interaction with PRKCZ.|Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		ACCTTTTGTTCGAAACTCCCT	0.507													13	11					0	0	0	0	T	167887709	T	T	167887709	4	4	168	1	0	0	0	0	0	1	0	0	17479	876	31	1	2956	1	WWC1	5	167887709	Nonsense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	14802082	167887709	13027551	56	31607											
DOCK2	1794	broad.mit.edu	37	chr5	169144446	169144446	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatttcaacaccgttctggAggcttacatccaacagcatt	11	11	7	12	1	2	0	1	0	1	0	3	1	3	1	2	2	4	4	2	2	3	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr5:169144446A>G	uc003maf.2	+	21	2170	c.2090A>G	c.(2089-2091)GAG>GGG	p.E697G	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.E189G	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	697					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACCGTTCTGGAGGCTTACATC	0.463													7	137					0	0	0	0	G	169144446	G	G	169144446	3	3	168	1	0	0	0	0	1	0	0	0	4709	304	11	5	2172	5	DOCK2	5	169144446	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	1256737	169144446	11770814	57	31608											
RIPK1	8737	broad.mit.edu	37	chr6	3105891	3105891	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagccgcatggacaggcaGacgaaacagcagcccagaca	14	1	13	13	2	0	2	0	0	0	2	0	4	0	3	2	3	4	4	2	3	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:3105891G>C	uc010jni.2	+	9	1414	c.1182G>C	c.(1180-1182)CAG>CAC	p.Q394H	RIPK1_uc003muv.3_Missense_Mutation_p.Q231H|RIPK1_uc003muw.3_Missense_Mutation_p.Q329H|RIPK1_uc011dhs.1_Missense_Mutation_p.Q348H|RIPK1_uc003mux.2_Missense_Mutation_p.Q394H	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	394	Interaction with SQSTM1.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TGGACAGGCAGACGAAACAGC	0.532													26	65					0	0	0	0	C	3105891	C	C	3105891	3	2	168	1	0	0	0	0	1	0	0	0	13445	933	33	2	1212	2	RIPK1	6	3105891	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08		3105891	168009176	58	31609											
HIVEP1	3096	broad.mit.edu	37	chr6	12122650	12122650	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgacaaaattggcactttCtatgatgatgtctttgtatc	11	16	8	6	0	2	3	0	3	2	0	3	4	2	3	0	1	0	2	0	1	4	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:12122650C>G	uc003nac.2	+	4	2801	c.2622C>G	c.(2620-2622)TTC>TTG	p.F874L	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	874					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TTGGCACTTTCTATGATGATG	0.473													24	134					0	0	0	0	G	12122650	G	G	12122650	3	3	168	1	0	0	0	0	1	0	0	0	7225	912	32	2	2632	2	HIVEP1	6	12122650	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	9016759	12122650	158992417	59	31610											
HIST1H2BD	3017	broad.mit.edu	37	chr6	26158508	26158508	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagcgcagccgcaaggagagCtattcagtgtatgtgtacaa	13	8	12	8	2	1	1	1	0	0	1	1	2	1	1	1	1	4	5	1	1	6	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:26158508C>G	uc003ngr.2	+	1	160	c.111C>G	c.(109-111)AGC>AGG	p.S37R	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.S37R	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	37					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						GCAAGGAGAGCTATTCAGTGT	0.542													17	166					0	0	0	0	G	26158508	G	G	26158508	3	3	168	1	0	0	0	0	1	0	0	0	7182	796	28	4	113	4	HIST1H2BD	6	26158508	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	14035858	26158508	144956559	60	31611											
TAF8	129685	broad.mit.edu	37	chr6	42036204	42036204	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctcttccaattcgccagtGattgctgccagacctttcac	7	13	6	15	1	2	2	1	1	1	1	5	2	3	2	4	0	2	1	4	0	1	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:42036204G>A	uc003ors.2	+	7	668	c.639G>A	c.(637-639)TTG>TTA	p.L213L	TAF8_uc003ort.2_Silent_p.L213L|TAF8_uc003oru.1_Silent_p.L213L|TAF8_uc003orv.1_Silent_p.L213L|TAF8_uc011dun.1_Intron	NM_138572	NP_612639	Q7Z7C8	TAF8_HUMAN	TBP-associated factor 8	213					cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			ovary(1)	1	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			ATTCGCCAGTGATTGCTGCCA	0.522													54	395					0	0	0	0	A	42036204	A	A	42036204	2	1	168	1	0	0	0	0	0	0	0	1	15600	1304	45	2		2	TAF8	6	42036204	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	15877696	42036204	129078863	61	31612											
ABCC10	89845	broad.mit.edu	37	chr6	43413457	43413457	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acatcctcctggccaacgcgGcaggcctgctggggctcctg	5	7	13	16	2	0	0	0	0	0	0	3	0	3	0	5	5	2	3	5	5	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:43413457G>T	uc003ouy.1	+	15	3366	c.3151G>T	c.(3151-3153)GCA>TCA	p.A1051S	ABCC10_uc003ouz.1_Missense_Mutation_p.A1023S|ABCC10_uc010jyo.1_Missense_Mutation_p.A157S	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1051	ABC transmembrane type-1 2.|Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCCAACGCGGCAGGCCTGCT	0.647													8	56					0.000157383	0.000164738	1	0	T	43413457	T	T	43413457	3	4	168	1	0	0	0	0	1	0	0	0	50	1203	42	4	3117	4	ABCC10	6	43413457	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	1377253	43413457	127701610	62	31613											
HTR1E	3354	broad.mit.edu	37	chr6	87726086	87726086	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatcaaccctctgctctataCgagttttaatgaagacttta	12	14	6	9	1	3	2	1	1	2	1	3	4	3	2	1	0	3	2	1	0	6	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:87726086C>A	uc003pli.2	+	2	1737	c.1034C>A	c.(1033-1035)ACG>AAG	p.T345K		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	345	Helical; Name=7; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CTGCTCTATACGAGTTTTAAT	0.438													14	51					1.99824e-07	2.18344e-07	1	0	A	87726086	A	A	87726086	3	1	168	1	0	0	0	0	1	0	0	0	7478	536	19	3	1036	3	HTR1E	6	87726086	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	44312629	87726086	83388981	63	31614											
EPHA7	2045	broad.mit.edu	37	chr6	94120310	94120310	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccttctgcactgcagtgcatCctgggggcgttttccgcttc	3	13	11	14	2	1	0	0	0	1	0	4	0	3	0	3	2	3	5	3	2	0	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:94120310C>T	uc003poe.2	-	3	982	c.741G>A	c.(739-741)AGG>AGA	p.R247R	EPHA7_uc003pof.2_Silent_p.R247R|EPHA7_uc011eac.1_Silent_p.R247R|EPHA7_uc003pog.3_Silent_p.R247R	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	247	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGCAGTGCATCCTGGGGGCGT	0.473													9	37					0	0	0	0	T	94120310	T	T	94120310	2	4	168	1	0	0	0	0	0	0	0	1	5196	854	30	2		2	EPHA7	6	94120310	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	6394224	94120310	76994757	64	31615											
FOXO3	2309	broad.mit.edu	37	chr6	108984767	108984767	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccctgatggggggaagagcgGaaaagccccccggcggcggg	8	2	19	12	4	0	2	0	1	0	1	0	4	0	4	4	7	2	0	4	7	3	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:108984767G>C	uc003psk.2	+	3	1047	c.731G>C	c.(730-732)GGA>GCA	p.G244A	FOXO3_uc003psn.2_Intron|FOXO3_uc003psm.2_Missense_Mutation_p.G244A|FOXO3_uc011ean.1_Missense_Mutation_p.G24A|FOXO3_uc010kdj.1_Missense_Mutation_p.G24A	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	244	Fork-head.|Nuclear localization signal.			PDGGKSGKA -> LMGEERKT (in Ref. 5; CAA04860).	antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		GGGAAGAGCGGAAAAGCCCCC	0.592													9	19					0	0	0	0	C	108984767	C	C	108984767	3	2	168	1	0	0	0	0	1	0	0	0	6058	1174	41	2	737	2	FOXO3	6	108984767	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	14864457	108984767	62130300	65	31616											
ROS1	6098	broad.mit.edu	37	chr6	117681060	117681060	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattatcagctgtgtagcaaAcggcactgataactctttct	11	13	7	10	1	3	1	1	1	2	0	3	1	3	1	0	1	4	4	0	1	4	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:117681060A>G	uc003pxp.1	-	23	3759	c.3560T>C	c.(3559-3561)GTT>GCT	p.V1187A	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1187	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGTGTAGCAAACGGCACTGAT	0.403			T	GOPC|ROS1	glioblastoma|NSCLC								13	83					0	0	0	0	G	117681060	G	G	117681060	3	3	168	1	0	0	0	0	1	0	0	0	13596	43	2	5	3567	5	ROS1	6	117681060	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	8696293	117681060	53434007	66	31617											
SGK1	6446	broad.mit.edu	37	chr6	134498960	134498960	+	5'Flank	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggaactctgagatgacaTgagagcacgagccagagacg	13	5	14	9	2	1	4	0	3	1	3	1	9	1	5	1	1	3	2	1	1	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:134498960T>C	uc003qen.3	-						SGK1_uc003qeo.3_Intron|SGK1_uc011ect.1_5'Flank|SGK1_uc011ecu.1_5'Flank|SGK1_uc011ecv.1_5'Flank|SGK1_uc011ecw.1_Missense_Mutation_p.M1V	NM_005627	NP_005618	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1 isoform						apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(3)|stomach(1)|lung(1)|central_nervous_system(1)	6	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		TGAGATGACATGAGAGCACGA	0.493													5	13					0	0	0	0	C	134498960	C	C	134498960	1	2	168	0	1	0	0	0	0	0	0	0	14272	1464	51	5		5	SGK1	6	134498960	5'Flank	SNP	T	TCGA-CV-5430-01A-02D-1683-08	16817900	134498960	36616107	67	31618											
FBXO30	84085	broad.mit.edu	37	chr6	146126707	146126708	+	Frame_Shift_Ins	INS	-	A	A																															ttacaaagagcagaagtgtcINSataagaacttgtattcaagt																										TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:146126707_146126708insA	uc003qla.2	-	2	1033_1034	c.834_835insT	c.(832-837)TATGACfs	p.Y278fs	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	278_279							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		GCAGAAGTGTCATAAGAACTTG	0.356													---	---	---								A	146126708	A	A	146126707	7	5	168	1	0	1	1	0	0	0	0	0	5772	826	29	0	1410	0	FBXO30	6	146126707	Frame_Shift_Ins	INS	-	TCGA-CV-5430-01A-02D-1683-08	11627747	146126707	24988360	68	31619											
C6orf97	80129	broad.mit.edu	37	chr6	151936765	151936765	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagtggtaaccagtgaaaTgaagacactaaaaaaatctc	20	7	8	6	0	1	4	0	2	1	2	2	4	1	4	1	1	1	1	1	1	8	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr6:151936765T>C	uc003qol.2	+	10	1987	c.1898T>C	c.(1897-1899)ATG>ACG	p.M633T		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	633	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		ACCAGTGAAATGAAGACACTA	0.398													38	45					0	0	0	0	C	151936765	C	C	151936765	3	2	168	1	0	0	0	0	1	0	0	0	2385	1464	51	5	1936	5	C6orf97	6	151936765	Missense_Mutation	SNP	T	TCGA-CV-5430-01A-02D-1683-08	5810058	151936765	19178302	69	31620											
FAM188B	84182	broad.mit.edu	37	chr7	30818091	30818091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catggaccaggaacgcccacGctctgacctcagcataaaca	13	5	8	15	2	2	1	1	1	1	0	2	3	2	3	3	2	3	2	3	2	3	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:30818091G>A	uc003tbt.2	+	2	184	c.107G>A	c.(106-108)CGC>CAC	p.R36H	FAM188B_uc010kwe.2_Missense_Mutation_p.R7H	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	36											0						GAACGCCCACGCTCTGACCTC	0.438													15	62					0	0	0	0	A	30818091	A	A	30818091	3	1	168	1	0	0	0	0	1	0	0	0	5543	1087	38	1	113	1	FAM188B	7	30818091	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08		30818091	128320572	70	31621											
VPS41	27072	broad.mit.edu	37	chr7	38781699	38781699	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcaacatgtgtgccaatgttGtttaacaagccagtaataaa	15	12	7	7	0	1	0	1	0	0	0	1	0	1	0	2	0	4	3	2	0	7	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:38781699G>T	uc003tgy.2	-	25	2171	c.2145C>A	c.(2143-2145)AAC>AAA	p.N715K	VPS41_uc003tgz.2_Missense_Mutation_p.N690K|VPS41_uc010kxn.2_Missense_Mutation_p.N626K|VPS41_uc003tgx.2_RNA	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	715					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TGCCAATGTTGTTTAACAAGC	0.323													6	27					0.000274275	0.000285756	1	0	T	38781699	T	T	38781699	3	4	168	1	0	0	0	0	1	0	0	0	17278	1368	48	4	439	4	VPS41	7	38781699	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	7963608	38781699	120356964	71	31622											
PKD1L1	168507	broad.mit.edu	37	chr7	47882701	47882701	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacttgtctacttttagcGaccaaaaatccataaagaat	15	13	4	9	1	2	1	0	0	2	1	3	2	3	1	2	0	3	0	2	0	8	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:47882701G>T	uc003tny.1	-	34	5304	c.5304C>A	c.(5302-5304)GTC>GTA	p.V1768V		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1768	Helical; (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TACTTTTAGCGACCAAAAATC	0.388													10	21					2.17888e-05	2.32414e-05	1	0	T	47882701	T	T	47882701	2	4	168	1	0	0	0	0	0	0	0	1	12019	1045	37	3		3	PKD1L1	7	47882701	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	9101002	47882701	111255962	72	31623											
SEMA3A	10371	broad.mit.edu	37	chr7	83610760	83610760	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	accggtgtaaagggagctggGcaaccccagccgttgaacca	11	5	13	12	2	0	1	0	1	0	0	0	2	0	2	5	3	4	4	5	3	4	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:83610760G>A	uc003uhz.2	-	14	1844	c.1529C>T	c.(1528-1530)GCC>GTC	p.A510V		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	510	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						AGGGAGCTGGGCAACCCCAGC	0.453													6	25					0	0	0	0	A	83610760	A	A	83610760	3	1	168	1	0	0	0	0	1	0	0	0	14089	1203	42	4	802	4	SEMA3A	7	83610760	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	35728059	83610760	75527903	73	31624											
FZD1	8321	broad.mit.edu	37	chr7	90895581	90895581	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccatcaagaccatcaccatCctggcgctgggccaggtgga	9	6	12	14	1	2	1	2	0	0	1	3	2	3	2	5	4	0	1	5	4	1	0	rs150597135		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:90895581C>T	uc003ula.2	+	1	1799	c.1386C>T	c.(1384-1386)ATC>ATT	p.I462I		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	462	Helical; Name=4; (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CCATCACCATCCTGGCGCTGG	0.647													27	86					0	0	0	0	T	90895581	T	T	90895581	2	4	168	1	0	0	0	0	0	0	0	1	6162	845	30	2		2	FZD1	7	90895581	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	7284821	90895581	68243082	74	31625											
AKAP9	10142	broad.mit.edu	37	chr7	91632007	91632007	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagacaaaacttttgtagcaGaaacattggaaatgggtgag	17	9	11	4	0	0	3	0	1	0	2	0	4	0	4	0	2	3	2	0	2	6	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:91632007G>C	uc003ulg.2	+	8	3001	c.2776G>C	c.(2776-2778)GAA>CAA	p.E926Q	AKAP9_uc003ule.2_Missense_Mutation_p.E938Q|AKAP9_uc003ulf.2_Missense_Mutation_p.E926Q|AKAP9_uc003uli.2_Missense_Mutation_p.E551Q	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	938	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTTTGTAGCAGAAACATTGGA	0.358			T	BRAF	papillary thyroid								9	38					0	0	0	0	C	91632007	C	C	91632007	3	2	168	1	0	0	0	0	1	0	0	0	459	943	33	2	2806	2	AKAP9	7	91632007	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	736426	91632007	67506656	75	31626											
PEX1	5189	broad.mit.edu	37	chr7	92147568	92147568	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagggaaacagcatgcagcTcctagaaccaacagacgaaa	18	3	9	11	1	0	2	0	0	0	2	1	4	1	3	2	1	6	3	2	1	6	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:92147568T>C	uc003uly.2	-	4	455	c.359A>G	c.(358-360)GAG>GGG	p.E120G	PEX1_uc011khr.1_5'UTR|PEX1_uc010ley.2_Missense_Mutation_p.E120G|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_5'Flank	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	120					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			AGCATGCAGCTCCTAGAACCA	0.303													24	36					0	0	0	0	C	92147568	C	C	92147568	3	2	168	1	0	0	0	0	1	0	0	0	11790	1565	54	5	3576	5	PEX1	7	92147568	Missense_Mutation	SNP	T	TCGA-CV-5430-01A-02D-1683-08	515561	92147568	66991095	76	31627											
SGCE	8910	broad.mit.edu	37	chr7	94257653	94257653	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aatttgtattaaatgttatgGgatcattactaatctcgcct	12	17	6	6	1	2	0	1	0	1	0	3	1	2	1	1	1	1	2	1	1	7	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:94257653G>A	uc003unl.2	-	3	362	c.251C>T	c.(250-252)CCC>CTC	p.P84L	SGCE_uc003unm.2_Missense_Mutation_p.P84L|SGCE_uc003unn.2_Missense_Mutation_p.P84L|SGCE_uc011kic.1_Missense_Mutation_p.P43L|SGCE_uc011kid.1_Missense_Mutation_p.P120L	NM_003919	NP_003910	O43556	SGCE_HUMAN	sarcoglycan, epsilon isoform 2	84	Extracellular (Potential).				cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AAATGTTATGGGATCATTACT	0.368													13	22					0	0	0	0	A	94257653	A	A	94257653	3	1	168	1	0	0	0	0	1	0	0	0	14267	1232	43	4	1250	4	SGCE	7	94257653	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	2110085	94257653	64881010	77	31628											
BRAF	673	broad.mit.edu	37	chr7	140501295	140501295	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	taaccacatgtttgacagcgGaaaccctggaaaagcagctt	14	8	9	10	1	0	1	0	1	0	0	0	3	0	3	2	2	5	3	2	2	4	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:140501295G>C	uc003vwc.3	-	6	838	c.777C>G	c.(775-777)TTC>TTG	p.F259L		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	259	Phorbol-ester/DAG-type.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TTTGACAGCGGAAACCCTGGA	0.358		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				5	31					0	0	0	0	C	140501295	C	C	140501295	3	2	168	1	0	0	0	0	1	0	0	0	1501	1165	41	2	1575	2	BRAF	7	140501295	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	46243642	140501295	18637368	78	31629											
CHPF2	54480	broad.mit.edu	37	chr7	150935153	150935153	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggctcgctgtgcgagcaGaggccccttcccaggtgcga	5	7	14	15	3	0	1	0	0	0	1	2	3	1	1	4	3	3	3	4	3	0	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:150935153G>C	uc003wjr.1	+	4	3218	c.1705G>C	c.(1705-1707)GAG>CAG	p.E569Q	CHPF2_uc003wjq.1_Missense_Mutation_p.E561Q|MIR671_hsa-mir-671|MI0003760_5'Flank	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	569	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						TGTGCGAGCAGAGGCCCCTTC	0.632													6	43					0	0	0	0	C	150935153	C	C	150935153	3	2	168	1	0	0	0	0	1	0	0	0	3384	943	33	2	1719	2	CHPF2	7	150935153	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	10433858	150935153	8203510	79	31630											
GALNT11	63917	broad.mit.edu	37	chr7	151798008	151798008	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagacacaaggaatgcagcgTatgtgccttatcggatttgc	11	10	11	9	2	0	1	0	0	0	1	1	3	0	3	1	2	4	2	1	2	4	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr7:151798008T>C	uc010lqg.1	+	3	649	c.419_splice	c.e3+2	p.A140_splice	GALNT11_uc011kvm.1_Splice_Site_p.A59_splice|GALNT11_uc003wku.2_Splice_Site_p.A140_splice|GALNT11_uc003wkv.1_Splice_Site_p.A140_splice|GALNT11_uc011kvn.1_Intron	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11							Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		GAATGCAGCGTATGTGCCTTA	0.448													3	123					0	0	0	0	C	151798008	C	C	151798008	5	2	168	1	0	0	0	0	0	0	1	0	6244	1652	57	5	427	5	GALNT11	7	151798008	Splice_Site	SNP	T	TCGA-CV-5430-01A-02D-1683-08	862855	151798008	7340655	80	31631											
CSGALNACT1	55790	broad.mit.edu	37	chr8	19315939	19315939	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtgcgaacaaaccaacctGaaattctgcatgaactgccg	14	7	8	12	3	1	2	0	2	1	0	1	3	1	2	3	0	7	1	3	0	5	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:19315939G>A	uc011kyn.1	-	5	1913	c.849C>T	c.(847-849)TTC>TTT	p.F283F	CSGALNACT1_uc011kyo.1_Silent_p.F283F|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Silent_p.F282F|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	283	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		AAACCAACCTGAAATTCTGCA	0.443													46	141					0	0	0	0	A	19315939	A	A	19315939	2	1	168	1	0	0	0	0	0	0	0	1	3955	1281	45	2		2	CSGALNACT1	8	19315939	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08		19315939	127048083	81	31632											
HR	55806	broad.mit.edu	37	chr8	21973860	21973860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggaaggctgggtccctggtGgcagagctgagcagagaggg	8	5	21	7	0	0	3	0	1	0	2	1	5	1	4	1	6	2	4	1	6	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:21973860G>A	uc003xas.2	-	18	4125	c.3460C>T	c.(3460-3462)CAC>TAC	p.H1154Y	HR_uc003xat.2_Missense_Mutation_p.H1099Y	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	1154	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGTCCCTGGTGGCAGAGCTGA	0.647													11	13					0	0	0	0	A	21973860	A	A	21973860	3	1	168	1	0	0	0	0	1	0	0	0	7386	1348	47	4	117	4	HR	8	21973860	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	2657921	21973860	124390162	82	31633											
NEFL	4747	broad.mit.edu	37	chr8	24813613	24813613	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtcgcggatctcctgctcGtacagcgcccggaagcggga	7	6	15	13	6	1	0	0	0	1	0	4	3	1	3	2	4	4	2	2	4	2	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:24813613G>C	uc003xee.2	-	1	519	c.417C>G	c.(415-417)TAC>TAG	p.Y139*		NM_006158	NP_006149	P07196	NFL_HUMAN	neurofilament, light polypeptide 68kDa	139	Rod.|Coil 1B.				anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		TCTCCTGCTCGTACAGCGCCC	0.682													4	11					0	0	0	0	C	24813613	C	C	24813613	4	2	168	1	0	0	0	0	0	1	0	0	10369	1140	40	3	1231	3	NEFL	8	24813613	Nonsense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	2839753	24813613	121550409	83	31634											
ERLIN2	11160	broad.mit.edu	37	chr8	37595472	37595473	+	Frame_Shift_Ins	INS	-	T	T																															ggagcagttgtggctgtggcINSttccagtttcttttgtgcat																										TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:37595472_37595473insT	uc003xke.3	+	2	147_148	c.32_33insT	c.(31-33)GCTfs	p.A11fs	uc003xkb.1_5'Flank|ERLIN2_uc003xkc.3_Frame_Shift_Ins_p.A11fs|ERLIN2_uc003xkd.2_Frame_Shift_Ins_p.A11fs|ERLIN2_uc003xkf.3_Frame_Shift_Ins_p.A11fs|ERLIN2_uc003xkg.2_Frame_Shift_Ins_p.A11fs	NM_007175	NP_009106	O94905	ERLN2_HUMAN	ER lipid raft associated 2 isoform 1	11	Helical; (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding				0		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GTGGCTGTGGCTTCCAGTTTCT	0.5													---	---	---								T	37595473	T	T	37595472	7	5	168	1	0	1	1	0	0	0	0	0	5257	797	28	0	34	0	ERLIN2	8	37595472	Frame_Shift_Ins	INS	-	TCGA-CV-5430-01A-02D-1683-08	12781859	37595472	108768550	84	31635											
TGS1	96764	broad.mit.edu	37	chr8	56699563	56699563	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagtgaaccacgtaatggagGaaccaatgaggaaagcaact	18	5	11	7	1	0	2	0	2	0	0	0	5	0	5	2	3	4	2	2	3	7	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	9432f890-557b-40b1-9db4-89bffd2748f8	g.chr8:56699563G>A	uc003xsj.3	+	4	1493	c.1106G>A	c.(1105-1107)GGA>GAA	p.G369E	TGS1_uc010lyh.2_Missense_Mutation_p.G273E	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	369					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			CGTAATGGAGGAACCAATGAG	0.438													5	52					0	0	0	0	A	56699563	A	A	56699563	3	1	168	1	0	0	0	0	1	0	0	0	15903	1174	41	2	1120	2	TGS1	8	56699563	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	19104091	56699563	89664459	85	31636											
ZFHX4	79776	broad.mit.edu	37	chr8	77616773	77616773	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gactccaaagaaagtgggcaGaatgcacagactggggcaaa	16	4	13	8	0	0	3	0	0	0	3	1	4	1	3	1	3	1	3	1	3	4	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:77616773G>C	uc003yav.2	+	2	837	c.450G>C	c.(448-450)CAG>CAC	p.Q150H	ZFHX4_uc003yat.1_Missense_Mutation_p.Q150H|ZFHX4_uc003yau.1_Missense_Mutation_p.Q150H|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q150H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	150						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAAGTGGGCAGAATGCACAGA	0.488										HNSCC(33;0.089)			27	21					0	0	0	0	C	77616773	C	C	77616773	3	2	168	1	0	0	0	0	1	0	0	0	17702	933	33	2	452	2	ZFHX4	8	77616773	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	20917210	77616773	68747249	86	31637											
TMEM64	169200	broad.mit.edu	37	chr8	91643854	91643854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cattgtccgcagggtggtacCcaagtaagaattcagaagct	12	9	11	9	1	1	2	1	0	0	2	2	2	2	2	2	2	2	4	2	2	5	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:91643854C>T	uc003yen.2	-	2	877	c.877G>A	c.(877-879)GGT>AGT	p.G293S	TMEM64_uc003yeo.2_Missense_Mutation_p.G32S|TMEM64_uc011lgf.1_Intron	NM_001008495	NP_001008495	Q6YI46	TMM64_HUMAN	transmembrane protein 64 isoform 1	293						integral to membrane					0			BRCA - Breast invasive adenocarcinoma(11;0.0598)			AGGGTGGTACCCAAGTAAGAA	0.423													106	51					0	0	0	0	T	91643854	T	T	91643854	3	4	168	1	0	0	0	0	1	0	0	0	16259	623	22	4	273	4	TMEM64	8	91643854	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	14027081	91643854	54720168	87	31638											
KIAA1429	25962	broad.mit.edu	37	chr8	95507153	95507153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacatagatttcaactgatCatccatgacatcagcaagca	15	9	5	12	0	3	3	3	2	0	1	4	3	4	3	2	0	3	2	2	0	3	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:95507153C>T	uc003ygo.1	-	20	4589	c.4576G>A	c.(4576-4578)GAT>AAT	p.D1526N	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1526					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTCAACTGATCATCCATGACA	0.308													6	291					0	0	0	0	T	95507153	T	T	95507153	3	4	168	1	0	0	0	0	1	0	0	0	8270	826	29	2	882	2	KIAA1429	8	95507153	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	3863299	95507153	50856869	88	31639											
VPS13B	157680	broad.mit.edu	37	chr8	100479733	100479733	+	Frame_Shift_Del	DEL	G	-	-																															ctttgcctagtggaacctatGggttgcacctccactctagc																										TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:100479733delG	uc003yiv.2	+	24	3648	c.3537delG	c.(3535-3537)ATGfs	p.M1179fs	VPS13B_uc003yiw.2_Frame_Shift_Del_p.M1179fs|VPS13B_uc003yiu.1_Frame_Shift_Del_p.M1179fs|VPS13B_uc003yix.1_Frame_Shift_Del_p.M649fs	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1179					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGGAACCTATGGGTTGCACCT	0.443													---	---	---								-	100479733	-	-	100479733	7	5	168	1	0	1	0	1	0	0	0	0	17258	1348	47	0	3750	0	VPS13B	8	100479733	Frame_Shift_Del	DEL	G	TCGA-CV-5430-01A-02D-1683-08	4972580	100479733	45884289	89	31640											
KCNV1	27012	broad.mit.edu	37	chr8	110984685	110984685	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taggaagcgacacctgtcccGcacacacaggaagcggagga	13	3	13	12	3	0	0	0	0	0	0	1	5	1	4	2	4	2	1	2	4	3	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:110984685G>A	uc003ynr.3	-	2	1135	c.793C>T	c.(793-795)CGG>TGG	p.R265W	KCNV1_uc010mcw.2_Missense_Mutation_p.R265W	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	265	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CACCTGTCCCGCACACACAGG	0.532													38	46					0	0	0	0	A	110984685	A	A	110984685	3	1	168	1	0	0	0	0	1	0	0	0	8133	1086	38	1	717	1	KCNV1	8	110984685	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	10504952	110984685	35379337	90	31641											
PTK2	5747	broad.mit.edu	37	chr8	141874416	141874416	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagtctctaatacctgttGatagaagaaattcaaagttg	15	12	8	6	0	2	3	1	1	1	2	3	3	2	3	1	0	2	3	1	0	6	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr8:141874416G>A	uc003yvu.2	-	5	675	c.445C>T	c.(445-447)CAA>TAA	p.Q149*	PTK2_uc003yvr.2_Nonsense_Mutation_p.Q48*|PTK2_uc003yvs.2_Nonsense_Mutation_p.Q149*|PTK2_uc003yvt.2_Nonsense_Mutation_p.Q171*|PTK2_uc003yvv.2_Nonsense_Mutation_p.Q36*|PTK2_uc011ljr.1_Nonsense_Mutation_p.Q149*	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	149	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			AATACCTGTTGATAGAAGAAA	0.264													11	134					0	0	0	0	A	141874416	A	A	141874416	4	1	168	1	0	0	0	0	0	1	0	0	12825	1299	45	2	2825	2	PTK2	8	141874416	Nonsense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	30889731	141874416	4489606	91	31642											
KIAA1432	57589	broad.mit.edu	37	chr9	5763345	5763345	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggatcatgctgcctttccAcatcaacatttacccgctag	9	11	7	14	2	2	0	2	0	0	0	3	1	3	1	3	1	4	2	3	1	3	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:5763345A>G	uc003zji.2	+	18	2174	c.2081A>G	c.(2080-2082)CAC>CGC	p.H694R	KIAA1432_uc003zjh.2_Missense_Mutation_p.H694R|KIAA1432_uc003zjl.3_Missense_Mutation_p.H657R|KIAA1432_uc003zjj.1_Missense_Mutation_p.H236R	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	773						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CTGCCTTTCCACATCAACATT	0.478													41	67					0	0	0	0	G	5763345	G	G	5763345	3	3	168	1	0	0	0	0	1	0	0	0	8272	159	6	5	2151	5	KIAA1432	9	5763345	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08		5763345	135450086	92	31643											
KIAA1432	57589	broad.mit.edu	37	chr9	5763371	5763371	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatttacccgctagctgttCtgtttgaagatgctttagtc	8	16	8	9	1	1	2	0	1	1	1	2	2	1	2	1	0	3	5	1	0	4	7			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:5763371C>A	uc003zji.2	+	18	2200	c.2107C>A	c.(2107-2109)CTG>ATG	p.L703M	KIAA1432_uc003zjh.2_Missense_Mutation_p.L703M|KIAA1432_uc003zjl.3_Missense_Mutation_p.L666M|KIAA1432_uc003zjj.1_Missense_Mutation_p.L245M	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	782						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GCTAGCTGTTCTGTTTGAAGA	0.478													47	82					1.32667e-27	1.54778e-27	1	0	A	5763371	A	A	5763371	3	1	168	1	0	0	0	0	1	0	0	0	8272	912	32	2	2177	2	KIAA1432	9	5763371	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	26	5763371	135450060	93	31644											
ZNF462	58499	broad.mit.edu	37	chr9	109688481	109688481	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcccaacagatatgggtaaGagataccagtgagccccaga	14	6	11	10	0	0	4	0	1	0	3	0	5	0	4	4	1	4	1	4	1	4	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:109688481G>C	uc004bcz.2	+	3	2577	c.2288G>C	c.(2287-2289)AGA>ACA	p.R763T	ZNF462_uc010mto.2_Missense_Mutation_p.R611T|ZNF462_uc004bda.2_Missense_Mutation_p.R611T	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	763					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						ATATGGGTAAGAGATACCAGT	0.488													7	30					0	0	0	0	C	109688481	C	C	109688481	3	2	168	1	0	0	0	0	1	0	0	0	17993	942	33	2	2294	2	ZNF462	9	109688481	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	103925110	109688481	31524950	94	31645											
EPB41L4B	54566	broad.mit.edu	37	chr9	111945031	111945031	+	Frame_Shift_Del	DEL	A	-	-																															taaactgtggccctgtggtgAaagtatcaggaaacgggttc																										TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:111945031delA	uc004bdz.1	-	24	2760	c.2465delT	c.(2464-2466)TTCfs	p.F822fs		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	822						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						CCCTGTGGTGAAAGTATCAGG	0.418													---	---	---								-	111945031	-	-	111945031	7	5	168	1	0	1	0	1	0	0	0	0	5180	246	9	0	249	0	EPB41L4B	9	111945031	Frame_Shift_Del	DEL	A	TCGA-CV-5430-01A-02D-1683-08	2256550	111945031	29268400	95	31646											
HDHD3	81932	broad.mit.edu	37	chr9	116136274	116136274	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgtgcggcactccctcaGggtgtcctcagccccatcca	5	8	10	18	2	2	0	2	0	0	0	5	0	5	0	6	2	2	1	6	2	0	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:116136274G>A	uc004bhi.1	-	2	1145	c.361C>T	c.(361-363)CTG>TTG	p.L121L	HDHD3_uc004bhj.2_Silent_p.L121L|HDHD3_uc004bhk.2_Silent_p.L121L	NM_031219	NP_112496	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain	121							phosphoglycolate phosphatase activity|protein binding				0						CACTCCCTCAGGGTGTCCTCA	0.602													27	102					0	0	0	0	A	116136274	A	A	116136274	2	1	168	1	0	0	0	0	0	0	0	1	7063	991	35	4		4	HDHD3	9	116136274	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	4191243	116136274	25077157	96	31647											
TNFSF8	944	broad.mit.edu	37	chr9	117666585	117666585	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgttccaagacaacttggTtttgtttagatgctttgcca	8	18	8	7	0	0	2	0	0	0	2	1	2	1	2	2	1	3	4	2	1	3	8			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:117666585T>C	uc004bji.1	-	4	518	c.331A>G	c.(331-333)ACC>GCC	p.T111A		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	111	Extracellular (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						GACAACTTGGTTTTGTTTAGA	0.378													48	46					0	0	0	0	C	117666585	C	C	117666585	3	2	168	1	0	0	0	0	1	0	0	0	16377	1725	60	5	377	5	TNFSF8	9	117666585	Missense_Mutation	SNP	T	TCGA-CV-5430-01A-02D-1683-08	1530311	117666585	23546846	97	31648											
STRBP	55342	broad.mit.edu	37	chr9	125909210	125909210	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgccatccacatctacaGacattgtgaagactggggca	11	10	10	10	0	1	3	0	1	1	2	2	3	2	3	2	2	2	1	2	2	2	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:125909210G>T	uc004bns.2	-	13	1692	c.1262C>A	c.(1261-1263)TCT>TAT	p.S421Y	STRBP_uc004bnt.2_Missense_Mutation_p.S239Y|STRBP_uc004bnu.2_Missense_Mutation_p.S407Y|STRBP_uc004bnv.2_Missense_Mutation_p.S421Y|STRBP_uc004bnr.2_Missense_Mutation_p.S33Y	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	421	DRBM 1.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						CACATCTACAGACATTGTGAA	0.453													27	56					2.65835e-16	3.06943e-16	1	0	T	125909210	T	T	125909210	3	4	168	1	0	0	0	0	1	0	0	0	15393	942	33	2	784	2	STRBP	9	125909210	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	8242625	125909210	15304221	98	31649											
LRRC8A	56262	broad.mit.edu	37	chr9	131669481	131669481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccgctactttgcggacaCgcagccagcataccggatcc	8	7	10	16	4	0	0	0	0	0	0	2	2	2	2	4	2	5	4	4	2	2	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr9:131669481C>T	uc004bwl.3	+	3	292	c.38C>T	c.(37-39)ACG>ATG	p.T13M	LRRC8A_uc010myp.2_Missense_Mutation_p.T13M|LRRC8A_uc010myq.2_Missense_Mutation_p.T13M	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	13					pre-B cell differentiation	integral to membrane					0						TTTGCGGACACGCAGCCAGCA	0.567													9	20					0	0	0	0	T	131669481	T	T	131669481	3	4	168	1	0	0	0	0	1	0	0	0	9071	536	19	1	40	1	LRRC8A	9	131669481	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	5760271	131669481	9543950	99	31650											
NET1	10276	broad.mit.edu	37	chr10	5498902	5498902	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagacacagcccggcatccGaagagcgagggacaaagccc	13	1	12	15	3	0	2	0	0	0	2	1	5	1	3	4	2	3	1	4	2	2	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:5498902G>A	uc001iia.2	+	12	1874	c.1736G>A	c.(1735-1737)CGA>CAA	p.R579Q	NET1_uc010qar.1_Missense_Mutation_p.R398Q|NET1_uc001iib.2_Missense_Mutation_p.R525Q|NET1_uc010qas.1_Missense_Mutation_p.R398Q	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	579					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						CCCGGCATCCGAAGAGCGAGG	0.493													9	38					0	0	0	0	A	5498902	A	A	5498902	3	1	168	1	0	0	0	0	1	0	0	0	10392	1058	37	1	1879	1	NET1	10	5498902	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08		5498902	130035845	100	31651											
CACNB2	783	broad.mit.edu	37	chr10	18439891	18439891	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atctgatactacctcaaataGttttgttcgccaggtaagag	12	13	8	8	1	2	2	1	1	1	1	3	2	2	2	2	1	2	3	2	1	5	7			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:18439891G>A	uc001ipr.2	+	2	260	c.200G>A	c.(199-201)AGT>AAT	p.S67N	CACNB2_uc009xjz.1_Missense_Mutation_p.S67N|CACNB2_uc001ips.2_Missense_Mutation_p.S67N|CACNB2_uc001ipt.2_Missense_Mutation_p.S67N|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Missense_Mutation_p.S39N|CACNB2_uc001ipv.2_Missense_Mutation_p.S39N|CACNB2_uc009xka.1_Missense_Mutation_p.S39N	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	67					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ACCTCAAATAGTTTTGTTCGC	0.313													8	78					0	0	0	0	A	18439891	A	A	18439891	3	1	168	1	0	0	0	0	1	0	0	0	2565	1029	36	4	246	4	CACNB2	10	18439891	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	12940989	18439891	117094856	101	31652											
C10orf71	118461	broad.mit.edu	37	chr10	50532323	50532323	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccccagaaggaccctacagCtgaccccagtgagccctctg	9	6	9	17	0	1	3	0	2	1	1	2	4	2	4	6	1	3	1	6	1	2	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:50532323C>T	uc010qgp.1	+	3	2072	c.1733C>T	c.(1732-1734)GCT>GTT	p.A578V		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	578											0						GACCCTACAGCTGACCCCAGT	0.547													14	8					0	0	0	0	T	50532323	T	T	50532323	3	4	168	1	0	0	0	0	1	0	0	0	1620	797	28	4	1735	4	C10orf71	10	50532323	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	32092432	50532323	85002424	102	31653											
STAMBPL1	57559	broad.mit.edu	37	chr10	90682924	90682924	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccaattttttctttcctaGatatgcaaacatgtgttggt	11	17	6	7	0	1	1	0	0	1	1	2	1	2	1	2	1	3	2	2	1	5	7			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:90682924G>C	uc001kfk.2	+	11	1678	c.1255_splice	c.e11-1	p.I419_splice	STAMBPL1_uc010qmx.1_Intron|STAMBPL1_uc009xto.2_Splice_Site|STAMBPL1_uc001kfl.2_Splice_Site_p.I419_splice|STAMBPL1_uc001kfn.2_Splice_Site_p.I253_splice	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1								metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TTCTTTCCTAGATATGCAAAC	0.313													6	20					0	0	0	0	C	90682924	C	C	90682924	5	2	168	1	0	0	0	0	0	0	1	0	15317	956	33	2	1292	2	STAMBPL1	10	90682924	Splice_Site	SNP	G	TCGA-CV-5430-01A-02D-1683-08	40150601	90682924	44851823	103	31654											
PNLIP	5406	broad.mit.edu	37	chr10	118306919	118306919	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaaaagatgtcaacaccCgcttcctcctatatactaat	13	11	3	14	1	1	1	1	0	0	1	4	1	4	1	4	0	2	1	4	0	7	5	rs142749694		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:118306919C>T	uc001lcm.2	+	3	203	c.160C>T	c.(160-162)CGC>TGC	p.R54C		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	54					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGTCAACACCCGCTTCCTCCT	0.373													35	16					0	0	0	0	T	118306919	T	T	118306919	3	4	168	1	0	0	0	0	1	0	0	0	12204	652	23	1	166	1	PNLIP	10	118306919	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	27623995	118306919	17227828	104	31655											
HSPA12A	259217	broad.mit.edu	37	chr10	118434882	118434882	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcggcaaagccgcccaccaGaaagaggaacttgacggtgg	12	4	13	12	3	0	3	0	1	0	2	1	4	0	4	3	4	2	1	3	4	3	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:118434882G>C	uc001lct.2	-	12	1543	c.1438C>G	c.(1438-1440)CTG>GTG	p.L480V	HSPA12A_uc001lcu.2_Missense_Mutation_p.L397V	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	480							ATP binding			ovary(1)	1				all cancers(201;0.0158)		CCGCCCACCAGAAAGAGGAAC	0.622													4	12					0	0	0	0	C	118434882	C	C	118434882	3	2	168	1	0	0	0	0	1	0	0	0	7443	933	33	2	593	2	HSPA12A	10	118434882	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	127963	118434882	17099865	105	31656											
CPXM2	119587	broad.mit.edu	37	chr10	125526664	125526664	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggaccagcctcccagctccGagccctggagacaagtgaga	10	4	13	14	1	0	2	0	1	0	2	2	6	2	3	5	2	3	1	5	2	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:125526664G>A	uc001lhk.1	-	10	1629	c.1304C>T	c.(1303-1305)TCG>TTG	p.S435L	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	435					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TCCCAGCTCCGAGCCCTGGAG	0.552													21	22					0	0	0	0	A	125526664	A	A	125526664	3	1	168	1	0	0	0	0	1	0	0	0	3853	1059	37	1	986	1	CPXM2	10	125526664	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	7091782	125526664	10008083	106	31657											
C10orf137	26098	broad.mit.edu	37	chr10	127429569	127429569	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttccctccctttctaaacaGatacttattgctgcctctgc	7	15	4	15	0	2	1	0	0	2	1	4	1	4	1	3	0	5	1	3	0	4	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr10:127429569G>C	uc001liq.1	+	17	2464	c.2171_splice	c.e17-1	p.D724_splice	C10orf137_uc001lin.2_Splice_Site_p.D690_splice|C10orf137_uc001lio.1_Splice_Site_p.D690_splice|C10orf137_uc001lip.1_Splice_Site_p.D428_splice|C10orf137_uc001lir.2_Splice_Site_p.D218_splice|C10orf137_uc001lis.1_Splice_Site_p.D50_splice	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TTTCTAAACAGATACTTATTG	0.378													29	100					0	0	0	0	C	127429569	C	C	127429569	5	2	168	1	0	0	0	0	0	0	1	0	1600	956	33	2	2130	2	C10orf137	10	127429569	Splice_Site	SNP	G	TCGA-CV-5430-01A-02D-1683-08	1902905	127429569	8105178	107	31658											
SLC17A6	57084	broad.mit.edu	37	chr11	22363086	22363086	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgcgcagggtgctggagaaGaagcaagacaccggggagac	12	2	17	10	3	0	4	0	0	0	4	0	6	0	4	2	4	2	3	2	4	3	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr11:22363086G>A	uc001mqk.2	+	2	512	c.99G>A	c.(97-99)AAG>AAA	p.K33K		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	33	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TGCTGGAGAAGAAGCAAGACA	0.642													11	45					0	0	0	0	A	22363086	A	A	22363086	2	1	168	1	0	0	0	0	0	0	0	1	14486	933	33	2		2	SLC17A6	11	22363086	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08		22363086	112643430	108	31659											
OR8H2	390151	broad.mit.edu	37	chr11	55872323	55872324	+	5'Flank	INS	-	T	T																															aaacagaaagtttttttttgINStttgttttttgttttttgag																								rs113669153		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr11:55872323_55872324insT	uc010riy.1	+							NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					Gtttttttttgtttgttttttg	0.109										HNSCC(53;0.14)			---	---	---								T	55872324	T	T	55872323	6	5	168	0	1	1	1	0	0	0	0	0	11292	1392	48	0		0	OR8H2	11	55872323	5'Flank	INS	-	TCGA-CV-5430-01A-02D-1683-08	33509237	55872323	79134193	109	31660											
SLC43A1	8501	broad.mit.edu	37	chr11	57268800	57268800	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtggtgttggtgctgctctCagctgaggagggggaaggga	6	9	21	5	0	1	1	1	1	1	0	2	4	1	4	0	7	3	4	0	7	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr11:57268800C>T	uc001nkk.2	-	3	275	c.157G>A	c.(157-159)GAG>AAG	p.E53K	SLC43A1_uc001nkl.2_Missense_Mutation_p.E53K	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	53					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						GTGCTGCTCTCAGCTGAGGAG	0.607													5	34					0	0	0	0	T	57268800	T	T	57268800	3	4	168	1	0	0	0	0	1	0	0	0	14696	835	29	2	1574	2	SLC43A1	11	57268800	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	1396477	57268800	77737716	110	31661											
VWA5A	4013	broad.mit.edu	37	chr11	123989062	123989062	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagctgcctctggaagcagAtggggctctgcgctttgtgc	5	10	16	10	1	2	1	0	0	2	1	2	3	2	3	1	4	5	4	1	4	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr11:123989062A>G	uc001pzu.2	+	5	622	c.413A>G	c.(412-414)GAT>GGT	p.D138G	VWA5A_uc001pzr.2_Missense_Mutation_p.D138G|VWA5A_uc001pzs.2_Missense_Mutation_p.D138G|VWA5A_uc010sae.1_Missense_Mutation_p.D154G|VWA5A_uc001pzt.2_Missense_Mutation_p.D138G	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	138										upper_aerodigestive_tract(1)|ovary(1)	2						CTGGAAGCAGATGGGGCTCTG	0.537													15	89					0	0	0	0	G	123989062	G	G	123989062	3	3	168	1	0	0	0	0	1	0	0	0	17310	333	12	5	423	5	VWA5A	11	123989062	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	66720262	123989062	11017454	111	31662											
M6PR	4074	broad.mit.edu	37	chr12	9095069	9095069	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggggaaactgctccattccTttggctcccactaccagtcg	7	11	9	14	1	0	0	0	0	0	0	4	1	3	1	4	3	3	2	4	3	2	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:9095069T>C	uc001qvf.2	-	6	824	c.654A>G	c.(652-654)AAA>AAG	p.K218K		NM_002355	NP_002346	P20645	MPRD_HUMAN	cation-dependent mannose-6-phosphate receptor	218	Cytoplasmic (Potential).				endosome to lysosome transport|receptor-mediated endocytosis	cell surface|endosome|integral to plasma membrane|lysosomal membrane	mannose binding|mannose transmembrane transporter activity|transmembrane receptor activity				0		Hepatocellular(102;0.137)		BRCA - Breast invasive adenocarcinoma(232;0.0146)		GCTCCATTCCTTTGGCTCCCA	0.478													47	269					0	0	0	0	C	9095069	C	C	9095069	2	2	168	1	0	0	0	0	0	0	0	1	9191	1606	56	5		5	M6PR	12	9095069	Silent	SNP	T	TCGA-CV-5430-01A-02D-1683-08		9095069	124756826	112	31663											
ESPL1	9700	broad.mit.edu	37	chr12	53663848	53663848	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagggtactgctctcttctGcagcagctgcgggatgatgg	6	10	16	9	1	2	1	0	1	2	0	3	3	2	3	0	4	6	5	0	4	1	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:53663848G>A	uc001sck.2	+	3	1213	c.1122G>A	c.(1120-1122)CTG>CTA	p.L374L	ESPL1_uc001scj.2_Silent_p.L49L	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	374					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GCTCTCTTCTGCAGCAGCTGC	0.537													23	11					0	0	0	0	A	53663848	A	A	53663848	2	1	168	1	0	0	0	0	0	0	0	1	5277	1306	46	4		4	ESPL1	12	53663848	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	44568779	53663848	80188047	113	31664											
HOXC4	3221	broad.mit.edu	37	chr12	54448755	54448755	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacccgaaggagaaggatCgagatcgcccactcgctgtg	10	6	13	12	4	0	3	0	1	0	2	3	7	0	4	2	2	0	1	2	2	2	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:54448755C>A	uc001seu.2	+	4	1241	c.561C>A	c.(559-561)ATC>ATA	p.I187I	HOXC4_uc001sex.2_Silent_p.I187I	NM_014620	NP_055435	P09017	HXC4_HUMAN	homeobox C4	187	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGAGAAGGATCGAGATCGCCC	0.537													13	8					3.45872e-05	3.65449e-05	1	0	A	54448755	A	A	54448755	2	1	168	1	0	0	0	0	0	0	0	1	7352	874	31	3		3	HOXC4	12	54448755	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	784907	54448755	79403140	114	31665											
GDF11	10220	broad.mit.edu	37	chr12	56143303	56143303	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcatccattcatggagctTcgagtcctagagaacacaaa	14	8	8	11	1	1	1	1	0	0	1	4	4	3	2	2	1	3	2	2	1	3	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:56143303T>C	uc001shq.2	+	3	898	c.861T>C	c.(859-861)CTT>CTC	p.L287L	GDF11_uc010spv.1_Silent_p.L287L	NM_005811	NP_005802	O95390	GDF11_HUMAN	growth differentiation factor 11 precursor	287					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			kidney(1)	1						TCATGGAGCTTCGAGTCCTAG	0.572													3	64					0	0	0	0	C	56143303	C	C	56143303	2	2	168	1	0	0	0	0	0	0	0	1	6349	1770	62	5		5	GDF11	12	56143303	Silent	SNP	T	TCGA-CV-5430-01A-02D-1683-08	1694548	56143303	77708592	115	31666											
HNF1A	6927	broad.mit.edu	37	chr12	121426777	121426777	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagggcactcccatgaagacGcagaagcgggccgccctgta	11	4	13	13	3	0	3	0	1	0	2	1	3	1	3	3	2	1	3	3	2	4	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr12:121426777G>A	uc001tzg.2	+	2	491	c.468G>A	c.(466-468)ACG>ACA	p.T156T	HNF1A_uc001tze.1_Silent_p.T156T|HNF1A_uc001tzf.2_Silent_p.T156T|HNF1A_uc010szn.1_Silent_p.T156T	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	156	Interaction with DNA.				glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCATGAAGACGCAGAAGCGGG	0.622									Hepatic_Adenoma_Familial_Clustering_of				10	19					0	0	0	0	A	121426777	A	A	121426777	2	1	168	1	0	0	0	0	0	0	0	1	7290	1074	38	1		1	HNF1A	12	121426777	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	65283474	121426777	12425118	116	31667											
BRCA2	675	broad.mit.edu	37	chr13	32913203	32913203	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaagaccctaaagtacagaGaggcctgtaaagaccttgaa	17	6	9	9	0	0	4	0	1	0	3	0	5	0	4	3	1	1	2	3	1	7	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr13:32913203G>A	uc001uub.1	+	11	4938	c.4711G>A	c.(4711-4713)GAG>AAG	p.E1571K		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1571					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAAGTACAGAGAGGCCTGTAA	0.383			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			45	31					0	0	0	0	A	32913203	A	A	32913203	3	1	168	1	0	0	0	0	1	0	0	0	1504	943	33	2	4749	2	BRCA2	13	32913203	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08		32913203	82256675	117	31668											
DNAJC15	29103	broad.mit.edu	37	chr13	43643083	43643083	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggtcgctacgcatttcggAtctggaaacctctagaacaa	12	10	9	10	3	2	1	0	0	2	1	4	3	2	3	1	3	3	2	1	3	6	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr13:43643083A>T	uc001uyy.2	+	3	579	c.178A>T	c.(178-180)ATC>TTC	p.I60F		NM_013238	NP_037370	Q9Y5T4	DJC15_HUMAN	DNAJ domain-containing	60						integral to membrane	heat shock protein binding				0		Lung NSC(96;4.3e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0737)		CGCATTTCGGATCTGGAAACC	0.333													7	12					0	0	0	0	T	43643083	T	T	43643083	3	4	168	1	0	0	0	0	1	0	0	0	4656	333	12	5	188	5	DNAJC15	13	43643083	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	10729880	43643083	71526795	118	31669											
LRRC16B	90668	broad.mit.edu	37	chr14	24532038	24532038	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaggagaccacagatgatGaacttgggaccaacattgtg	14	8	12	7	0	0	5	0	3	0	2	0	7	0	6	2	2	2	0	2	2	2	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr14:24532038G>A	uc001wlj.2	+	29	2846	c.2689G>A	c.(2689-2691)GAA>AAA	p.E897K	LRRC16B_uc001wlk.2_5'UTR	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	897										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		CACAGATGATGAACTTGGGAC	0.597													8	85					0	0	0	0	A	24532038	A	A	24532038	3	1	168	1	0	0	0	0	1	0	0	0	9022	1291	45	2	2803	2	LRRC16B	14	24532038	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08		24532038	82817502	119	31670											
NRL	4901	broad.mit.edu	37	chr14	24551828	24551829	+	In_Frame_Ins	INS	-	GGT	GGT																															ccccagctgctgctgcagggINStagccagccagtacagctcc																										TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr14:24551828_24551829insGGT	uc001wlo.2	-	2	360_361	c.229_230insACC	c.(229-231)ACC>AACCCC	p.77_77T>NP	NRL_uc001wlp.2_In_Frame_Ins_p.77_77T>NP|NRL_uc001wlq.2_In_Frame_Ins_p.77_77T>NP	NM_006177	NP_006168	P54845	NRL_HUMAN	neural retina leucine zipper	77					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding				0				GBM - Glioblastoma multiforme(265;0.0181)		CTGCTGCAGGGTAGCCAGCCAG	0.658													---	---	---								GGT	24551829	GGT	GGT	24551828	7	5	168	1	0	1	1	0	0	0	0	0	10710	1261	44	0	491	0	NRL	14	24551828	In_Frame_Ins	INS	-	TCGA-CV-5430-01A-02D-1683-08	19790	24551828	82797712	120	31671											
ADCY4	196883	broad.mit.edu	37	chr14	24789048	24789048	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actccttgaagtctgggactGaggcgaagaggacacaaacg	13	6	13	9	2	1	3	0	2	1	1	2	6	2	5	1	3	1	0	1	3	3	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr14:24789048G>C	uc001wov.2	-	21	2639	c.2633C>G	c.(2632-2634)TCA>TGA	p.S878*	ADCY4_uc001wow.2_Nonsense_Mutation_p.S878*|ADCY4_uc010toh.1_Nonsense_Mutation_p.S564*|ADCY4_uc001wox.2_Nonsense_Mutation_p.S878*|ADCY4_uc001woy.2_Nonsense_Mutation_p.S878*	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	878	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		GTCTGGGACTGAGGCGAAGAG	0.493													6	76					0	0	0	0	C	24789048	C	C	24789048	4	2	168	1	0	0	0	0	0	1	0	0	296	1294	45	2	620	2	ADCY4	14	24789048	Nonsense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	237220	24789048	82560492	121	31672											
C14orf106	55320	broad.mit.edu	37	chr14	45679696	45679696	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgtccatatttggcagaatAtcatcatcatcttcactgtc	10	16	5	10	0	5	1	4	0	1	1	7	1	6	1	1	1	0	1	1	1	3	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr14:45679696A>T	uc001wwf.2	-	14	3498	c.3039T>A	c.(3037-3039)GAT>GAA	p.D1013E		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	1013	Poly-Asp.				cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TTGGCAGAATATCATCATCAT	0.373													14	97					0	0	0	0	T	45679696	T	T	45679696	3	4	168	1	0	0	0	0	1	0	0	0	1744	446	16	5	375	5	C14orf106	14	45679696	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	20890648	45679696	61669844	122	31673											
SIPA1L1	26037	broad.mit.edu	37	chr14	72169178	72169178	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtggcagcggaaaatccaCgcctagctggcaaagaagtg	12	6	14	9	2	0	1	0	0	0	1	1	2	1	2	2	4	2	3	2	4	5	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr14:72169178C>T	uc001xms.2	+	12	3950	c.3602C>T	c.(3601-3603)ACG>ATG	p.T1201M	SIPA1L1_uc001xmt.2_Missense_Mutation_p.T1201M|SIPA1L1_uc001xmu.2_Missense_Mutation_p.T1201M|SIPA1L1_uc001xmv.2_Missense_Mutation_p.T1201M|SIPA1L1_uc010ttm.1_Missense_Mutation_p.T676M|SIPA1L1_uc001xmw.2_Translation_Start_Site	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1201					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GGAAAATCCACGCCTAGCTGG	0.478													8	27					0	0	0	0	T	72169178	T	T	72169178	3	4	168	1	0	0	0	0	1	0	0	0	14394	536	19	1	3644	1	SIPA1L1	14	72169178	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	26489482	72169178	35180362	123	31674											
GABRB3	2562	broad.mit.edu	37	chr15	26806279	26806279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gattttgggcaaggtctcccGaaggtgggtgttgatggttg	6	13	17	5	1	1	1	0	1	1	0	2	3	1	1	1	5	0	3	1	5	2	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr15:26806279G>A	uc001zaz.2	-	8	1022	c.880C>T	c.(880-882)CGG>TGG	p.R294W	GABRB3_uc010uae.1_Missense_Mutation_p.R209W|GABRB3_uc001zba.2_Missense_Mutation_p.R294W|GABRB3_uc001zbb.2_Missense_Mutation_p.R350W	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	294					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AAGGTCTCCCGAAGGTGGGTG	0.473													12	47					0	0	0	0	A	26806279	A	A	26806279	3	1	168	1	0	0	0	0	1	0	0	0	6202	1057	37	1	549	1	GABRB3	15	26806279	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08		26806279	75725113	124	31675											
FSIP1	161835	broad.mit.edu	37	chr15	40057834	40057834	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tattctcatttctagaccttGcttcttaatttctttttctc	6	23	2	10	0	5	1	1	0	5	1	7	1	5	1	1	0	1	1	1	0	3	10			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr15:40057834G>C	uc001zki.2	-	4	642	c.424C>G	c.(424-426)CAA>GAA	p.Q142E		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	142	Potential.									ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		TCTAGACCTTGCTTCTTAATT	0.284													8	25					0	0	0	0	C	40057834	C	C	40057834	3	2	168	1	0	0	0	0	1	0	0	0	6108	1328	46	4	1357	4	FSIP1	15	40057834	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	13251555	40057834	62473558	125	31676											
BAHD1	22893	broad.mit.edu	37	chr15	40750963	40750963	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgacctgcccaagcccccCagcccggccccatccagtga	7	4	8	22	1	0	2	0	2	0	0	1	2	1	2	10	1	3	0	10	1	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr15:40750963C>G	uc001zlu.2	+	2	371	c.300C>G	c.(298-300)CCC>CCG	p.P100P	BAHD1_uc001zlt.2_Silent_p.P100P|BAHD1_uc010bbp.1_Silent_p.P100P|BAHD1_uc001zlv.2_Silent_p.P100P	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	100					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CCAAGCCCCCCAGCCCGGCCC	0.657													4	41					0	0	0	0	G	40750963	G	G	40750963	2	3	168	1	0	0	0	0	0	0	0	1	1299	581	21	4		4	BAHD1	15	40750963	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	693129	40750963	61780429	126	31677											
C16orf11	146325	broad.mit.edu	37	chr16	615181	615181	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agcgtcccacccccagggctCcccctcgcagccccagatga	7	4	9	21	2	0	2	0	1	0	1	3	2	2	2	7	1	2	2	7	1	0	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:615181C>G	uc002chk.2	+	3	1869	c.1590C>G	c.(1588-1590)CTC>CTG	p.L530L	NHLRC4_uc002chl.2_5'Flank|PIGQ_uc010bqw.2_5'Flank	NM_145270	NP_660313	P0CG20	CP011_HUMAN	hypothetical protein LOC146325	530										central_nervous_system(1)	1						CCCCAGGGCTCCCCCTCGCAG	0.692													11	16					0	0	0	0	G	615181	G	G	615181	2	3	168	1	0	0	0	0	0	0	0	1	1816	842	30	2		2	C16orf11	16	615181	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08		615181	89739572	127	31678											
MSLNL	401827	broad.mit.edu	37	chr16	825511	825511	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaagcagctgagctgggcaGaacggcgctccctcgtgact	8	6	13	14	3	0	3	0	2	0	1	2	3	1	3	2	2	4	5	2	2	2	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:825511G>C	uc002cjz.1	-	5	1250	c.1250C>G	c.(1249-1251)TCT>TGT	p.S417C		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4						GAGCTGGGCAGAACGGCGCTC	0.682													6	14					0	0	0	0	C	825511	C	C	825511	3	2	168	1	0	0	0	0	1	0	0	0	9935	942	33	2	1959	2	MSLNL	16	825511	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	210330	825511	89529242	128	31679											
ZNF598	90850	broad.mit.edu	37	chr16	2053040	2053040	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagaagagctcatgctgcctCcgcatgtgctgctccaggtc	7	9	11	14	1	1	2	1	0	0	2	4	2	3	2	3	1	5	5	3	1	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	9432f890-557b-40b1-9db4-89bffd2748f8	g.chr16:2053040C>T	uc002cof.1	-	5	432	c.417G>A	c.(415-417)CGG>CGA	p.R139R	ZNF598_uc002coe.1_5'Flank	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	139						intracellular	zinc ion binding			lung(1)|breast(1)	2						CATGCTGCCTCCGCATGTGCT	0.677													4	6					0	0	0	0	T	2053040	T	T	2053040	2	4	168	1	0	0	0	0	0	0	0	1	18095	842	30	2		2	ZNF598	16	2053040	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	1227529	2053040	88301713	129	31680											
ZNF598	90850	broad.mit.edu	37	chr16	2053657	2053657	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatctgcaaagtagatatCatatttcttctcatgctgca	11	15	5	10	0	4	1	2	0	3	1	6	1	5	1	1	0	3	4	1	0	4	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:2053657C>T	uc002cof.1	-	4	310	c.295G>A	c.(295-297)GAT>AAT	p.D99N	ZNF598_uc002coe.1_5'Flank	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	99						intracellular	zinc ion binding			lung(1)|breast(1)	2						AAGTAGATATCATATTTCTTC	0.547											OREG0023548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	42					0	0	0	0	T	2053657	T	T	2053657	3	4	168	1	0	0	0	0	1	0	0	0	18095	826	29	2	2463	2	ZNF598	16	2053657	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	617	2053657	88301096	130	31681											
PPL	5493	broad.mit.edu	37	chr16	4934903	4934903	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtccacgatctcctccctGagccgctgaagctccttctc	5	12	7	17	2	2	2	0	2	2	0	7	3	5	2	5	0	2	2	5	0	1	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:4934903G>C	uc002cyd.1	-	22	3843	c.3753C>G	c.(3751-3753)CTC>CTG	p.L1251L		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1251	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TCTCCTCCCTGAGCCGCTGAA	0.522													14	59					0	0	0	0	C	4934903	C	C	4934903	2	2	168	1	0	0	0	0	0	0	0	1	12394	1277	45	2		2	PPL	16	4934903	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	2881246	4934903	85419850	131	31682											
ACSM3	6296	broad.mit.edu	37	chr16	20781560	20781560	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaagatgtcctggaccaatgGactgataaggaaaaggtatg	16	8	12	5	0	0	2	0	1	0	1	1	5	1	5	2	4	0	1	2	4	6	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:20781560G>A	uc002dhr.2	+	2	391	c.204G>A	c.(202-204)TGG>TGA	p.W68*	ACSM3_uc002dhq.2_Nonsense_Mutation_p.W68*|ACSM3_uc010vba.1_Nonsense_Mutation_p.W60*	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	68					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						TGGACCAATGGACTGATAAGG	0.328													4	30					0	0	0	0	A	20781560	A	A	20781560	4	1	168	1	0	0	0	0	0	1	0	0	185	1183	41	2	206	2	ACSM3	16	20781560	Nonsense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	15846657	20781560	69573193	132	31683											
CD2BP2	10421	broad.mit.edu	37	chr16	30364880	30364880	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccgggccaccatctggtcgGccaacccggagagccggtcc	6	4	13	18	4	1	1	0	0	1	1	3	2	2	1	7	5	2	0	7	5	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:30364880G>A	uc002dxr.2	-	4	870	c.617C>T	c.(616-618)GCC>GTC	p.A206V	CD2BP2_uc002dxs.2_Missense_Mutation_p.A206V	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	206					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						CATCTGGTCGGCCAACCCGGA	0.657													3	22					0	0	0	0	A	30364880	A	A	30364880	3	1	168	1	0	0	0	0	1	0	0	0	3010	1203	42	4	420	4	CD2BP2	16	30364880	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	9583320	30364880	59989873	133	31684											
ZNF689	115509	broad.mit.edu	37	chr16	30621254	30621254	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccactcctccggggagaagtAcacggccacgtccacgaact	10	5	10	16	4	0	1	0	0	0	1	3	3	3	1	5	3	2	1	5	3	3	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:30621254A>G	uc002dyx.2	-	1	429	c.109T>C	c.(109-111)TAC>CAC	p.Y37H	ZNF689_uc010bzy.2_Intron	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GGGGAGAAGTACACGGCCACG	0.692													2	11					0	0	0	0	G	30621254	G	G	30621254	3	3	168	1	0	0	0	0	1	0	0	0	18161	391	14	5	1405	5	ZNF689	16	30621254	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	256374	30621254	59733499	134	31685											
KLHDC4	54758	broad.mit.edu	37	chr16	87744911	87744911	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatcgttgaagaactcgcccGacaggctctcctcctcttcc	7	10	8	16	3	2	2	0	1	2	1	7	4	4	2	4	1	1	2	4	1	2	2	rs113844965		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr16:87744911G>A	uc002fki.2	-	9	1020	c.974C>T	c.(973-975)TCG>TTG	p.S325L	KLHDC4_uc002fkh.1_5'Flank|KLHDC4_uc010cht.1_Missense_Mutation_p.S144L|KLHDC4_uc002fkj.2_Missense_Mutation_p.S294L|KLHDC4_uc002fkk.2_Missense_Mutation_p.S144L|KLHDC4_uc002fkl.2_Missense_Mutation_p.S268L|KLHDC4_uc010chu.1_Missense_Mutation_p.S144L	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	325	Kelch 5.									pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		GAACTCGCCCGACAGGCTCTC	0.582													9	33					0	0	0	0	A	87744911	A	A	87744911	3	1	168	1	0	0	0	0	1	0	0	0	8397	1059	37	1	600	1	KLHDC4	16	87744911	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	57123657	87744911	2609842	135	31686											
OR1E1	8387	broad.mit.edu	37	chr17	3301357	3301357	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcggtcataggccatggcCacaaggaggaagctctccag	11	6	13	11	1	2	0	1	0	1	0	3	2	2	2	3	5	2	1	3	5	4	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:3301357C>T	uc002fvj.1	-	1	348	c.348G>A	c.(346-348)GTG>GTA	p.V116V		NM_003553	NP_003544	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGCCATGGCCACAAGGAGGA	0.577													13	26					0	0	0	0	T	3301357	T	T	3301357	2	4	168	1	0	0	0	0	0	0	0	1	11008	581	21	4		4	OR1E1	17	3301357	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08		3301357	77893853	136	31687											
GSG2	83903	broad.mit.edu	37	chr17	3629572	3629572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggagttccacaggacaatGctgaacttcagctctgccac	11	8	9	13	0	2	1	1	1	1	0	3	3	3	3	2	2	4	3	2	2	2	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:3629572G>A	uc002fwp.2	+	1	2376	c.2343G>A	c.(2341-2343)ATG>ATA	p.M781I	ITGAE_uc002fwo.3_Intron|ITGAE_uc002fwn.3_5'Flank	NM_031965	NP_114171	Q8TF76	HASP_HUMAN	haspin	781	Protein kinase.				cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity				0						ACAGGACAATGCTGAACTTCA	0.433													11	34					0	0	0	0	A	3629572	A	A	3629572	3	1	168	1	0	0	0	0	1	0	0	0	6861	1319	46	4	2345	4	GSG2	17	3629572	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	328215	3629572	77565638	137	31688											
ZZEF1	23140	broad.mit.edu	37	chr17	3961378	3961378	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caacaaagaaggcgagatcaTtgggttcccagcccatatcc	13	7	9	12	1	1	2	1	0	0	2	3	3	3	2	3	2	2	1	3	2	4	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:3961378T>C	uc002fxe.2	-	32	5139	c.5075A>G	c.(5074-5076)AAT>AGT	p.N1692S	ZZEF1_uc002fxh.2_Missense_Mutation_p.N6S|ZZEF1_uc002fxi.2_5'UTR|ZZEF1_uc002fxj.1_Missense_Mutation_p.N305S	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1692							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGCGAGATCATTGGGTTCCCA	0.458													10	23					0	0	0	0	C	3961378	C	C	3961378	3	2	168	1	0	0	0	0	1	0	0	0	18322	1493	52	5	3906	5	ZZEF1	17	3961378	Missense_Mutation	SNP	T	TCGA-CV-5430-01A-02D-1683-08	331806	3961378	77233832	138	31689											
NLRP1	22861	broad.mit.edu	37	chr17	5486123	5486123	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggttggctgggagacccCaggtggggttcacttgggct	4	10	19	8	0	1	1	1	0	0	1	1	2	1	1	2	7	0	4	2	7	0	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:5486123C>T	uc002gci.2	-	2	870	c.315G>A	c.(313-315)CTG>CTA	p.L105L	NLRP1_uc002gcg.1_Silent_p.L105L|NLRP1_uc002gck.2_Silent_p.L105L|NLRP1_uc002gcj.2_Silent_p.L105L|NLRP1_uc002gcl.2_Silent_p.L105L|NLRP1_uc002gch.3_Silent_p.L105L|NLRP1_uc010clh.2_Silent_p.L105L	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	105					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				TGGGAGACCCCAGGTGGGGTT	0.602													3	32					0	0	0	0	T	5486123	T	T	5486123	2	4	168	1	0	0	0	0	0	0	0	1	10525	581	21	4		4	NLRP1	17	5486123	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	1524745	5486123	75709087	139	31690											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	5	11	9	16	2	3	0	0	0	3	0	7	1	5	1	3	3	1	1	3	3	0	2	rs28934574		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	32					0	0	0	0	A	7577094	A	A	7577094	3	1	168	1	0	0	0	0	1	0	0	0	16448	1115	39	1	442	1	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	2090971	7577094	73618116	140	31691											
TP53	7157	broad.mit.edu	37	chr17	7579410	7579420	+	Frame_Shift_Del	DEL	GGGGCCAGGAG	-	-																															ggaagggacagaagatgacaGgggccaggagggggctggtg																										TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:7579410_7579420delGGGGCCAGGAG	uc002gim.2	-	4	461_471	c.267_277delCTCCTGGCCCC	c.(265-279)CCCTCCTGGCCCCTGfs	p.P89fs	TP53_uc002gig.1_Frame_Shift_Del_p.P89fs|TP53_uc002gih.2_Frame_Shift_Del_p.P89fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.P89fs|TP53_uc010cni.1_Frame_Shift_Del_p.P89fs|TP53_uc002gij.2_Frame_Shift_Del_p.P89fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.P50fs|TP53_uc010cnk.1_Frame_Shift_Del_p.P104fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	89_93	Interaction with WWOX.		L -> P (in a sporadic cancer; somatic mutation).|L -> M (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W91*(11)|p.0?(7)|p.A76_S90del15(3)|p.G59fs*23(3)|p.P89S(3)|p.L93fs*30(2)|p.P85fs*58(1)|p.W91fs*57(1)|p.W91fs*13(1)|p.A88fs*52(1)|p.V73fs*9(1)|p.D48fs*55(1)|p.L93M(1)|p.P87fs*54(1)|p.P89L(1)|p.P92fs*57(1)|p.S33fs*23(1)|p.A86fs*33(1)|p.A86fs*32(1)|p.P13fs*18(1)|p.P89fs*60(1)|p.S90F(1)|p.P92A(1)|p.P92L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAGATGACAGGGGCCAGGAGGGGGCTGGTG	0.626		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7579420	-	-	7579410	7	5	168	1	0	1	0	1	0	0	0	0	16448	991	35	0	1025	0	TP53	17	7579410	Frame_Shift_Del	DEL	GGGGCCAGGAG	TCGA-CV-5430-01A-02D-1683-08	2316	7579410	73615800	141	31692											
DNAH2	146754	broad.mit.edu	37	chr17	7667311	7667311	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagatggctgctgggcgcctCctggagctgcacacctacct	6	8	13	14	1	0	1	0	0	0	1	1	3	1	2	4	3	4	4	4	3	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:7667311C>G	uc002giu.1	+	18	3155	c.3141C>G	c.(3139-3141)CTC>CTG	p.L1047L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1047	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTGGGCGCCTCCTGGAGCTGC	0.622													7	49					0	0	0	0	G	7667311	G	G	7667311	2	3	168	1	0	0	0	0	0	0	0	1	4624	842	30	2		2	DNAH2	17	7667311	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	87901	7667311	73527899	142	31693											
MYH3	4621	broad.mit.edu	37	chr17	10545560	10545560	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttgtatttttcttaccctGaaaagggcagagacagtttg	11	14	9	7	0	1	2	0	1	1	1	1	3	1	2	1	1	1	3	1	1	4	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:10545560G>A	uc002gmq.1	-	16	2033	c.1956C>T	c.(1954-1956)TTC>TTT	p.F652F		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	652	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TTCTTACCCTGAAAAGGGCAG	0.388													8	32					0	0	0	0	A	10545560	A	A	10545560	2	1	168	1	0	0	0	0	0	0	0	1	10089	1281	45	2		2	MYH3	17	10545560	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	2878249	10545560	70649650	143	31694											
KRTAP1-5	83895	broad.mit.edu	37	chr17	39183231	39183231	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcagcttggctggcagcaActggagctgcaggtcccact	8	7	13	13	0	0	0	0	0	0	0	1	1	1	1	1	4	6	7	1	4	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	9432f890-557b-40b1-9db4-89bffd2748f8	g.chr17:39183231A>G	uc002hvu.2	-	1	224	c.177T>C	c.(175-177)AGT>AGC	p.S59S		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	59	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCTGGCAGCAACTGGAGCTGC	0.617													4	53					0	0	0	0	G	39183231	G	G	39183231	2	3	168	1	0	0	0	0	0	0	0	1	8543	40	2	5		5	KRTAP1-5	17	39183231	Silent	SNP	A	TCGA-CV-5430-01A-02D-1683-08	28637671	39183231	42011979	144	31695											
NBR1	4077	broad.mit.edu	37	chr17	41347008	41347008	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtcctttgagctgttggatAtaaacattgttcaagagttg	10	16	10	5	0	1	2	1	1	0	1	2	3	2	3	1	1	2	4	1	1	4	7			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:41347008A>G	uc010czd.2	+	14	1842	c.1702A>G	c.(1702-1704)ATA>GTA	p.I568V	NBR1_uc010diz.2_Missense_Mutation_p.I568V|NBR1_uc010whu.1_Missense_Mutation_p.I568V|NBR1_uc010whv.1_Missense_Mutation_p.I568V|NBR1_uc010whw.1_Missense_Mutation_p.I547V|NBR1_uc010whx.1_3'UTR	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	568	ATG8 family protein-binding.				macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GCTGTTGGATATAAACATTGT	0.438													8	26					0	0	0	0	G	41347008	G	G	41347008	3	3	168	1	0	0	0	0	1	0	0	0	10254	449	16	5	1752	5	NBR1	17	41347008	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	2163777	41347008	39848202	145	31696											
MPP3	4356	broad.mit.edu	37	chr17	41888554	41888554	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actccttccttctcatggctCtttcggggcctggtggtatc	3	15	10	13	1	2	0	1	0	2	0	7	0	4	0	3	5	0	2	3	5	1	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:41888554C>G	uc002iei.3	-	17	1441	c.1275G>C	c.(1273-1275)AAG>AAC	p.K425N	MPP3_uc002ieh.2_Missense_Mutation_p.K450N|MPP3_uc002iej.2_RNA	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	425	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		TCTCATGGCTCTTTCGGGGCC	0.488													12	47					0	0	0	0	G	41888554	G	G	41888554	3	3	168	1	0	0	0	0	1	0	0	0	9788	912	32	2	498	2	MPP3	17	41888554	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	541546	41888554	39306656	146	31697											
ITGA3	3675	broad.mit.edu	37	chr17	48145541	48145541	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccagtgatgactggcagaCctaccacaacgagatgtgca	12	7	10	12	1	0	4	0	2	0	2	1	5	1	4	3	1	3	2	3	1	2	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:48145541C>G	uc010dbl.2	+	4	1000	c.536C>G	c.(535-537)ACC>AGC	p.T179S	ITGA3_uc010dbm.2_Missense_Mutation_p.T179S	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	179	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						GACTGGCAGACCTACCACAAC	0.582													8	85					0	0	0	0	G	48145541	G	G	48145541	3	3	168	1	0	0	0	0	1	0	0	0	7916	507	18	4	550	4	ITGA3	17	48145541	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	6256987	48145541	33049669	147	31698											
USH1G	124590	broad.mit.edu	37	chr17	72915717	72915717	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tctcctgccgcaggagggcgGcaaagtcctccatgtgcaga	8	7	13	13	2	1	1	0	0	1	1	4	2	3	2	4	3	2	3	4	3	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:72915717G>A	uc002jme.1	-	2	1397	c.1214C>T	c.(1213-1215)GCC>GTC	p.A405V	USH1G_uc010wro.1_Missense_Mutation_p.A302V	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	405	SAM.				equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					CAGGAGGGCGGCAAAGTCCTC	0.627													4	60					0	0	0	0	A	72915717	A	A	72915717	3	1	168	1	0	0	0	0	1	0	0	0	17103	1203	42	4	179	4	USH1G	17	72915717	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	24770176	72915717	8279493	148	31699											
TNRC6C	57690	broad.mit.edu	37	chr17	76045225	76045225	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcaccaatggcgcactcGtccaaagcccttctaatcag	11	8	8	14	2	2	0	1	0	1	0	4	0	3	0	3	2	1	2	3	2	3	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr17:76045225G>A	uc002jud.2	+	4	682	c.82G>A	c.(82-84)GTC>ATC	p.V28I	TNRC6C_uc002juf.2_Missense_Mutation_p.V28I|TNRC6C_uc002jue.2_Missense_Mutation_p.V28I	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	28	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TGGCGCACTCGTCCAAAGCCC	0.557													11	59					0	0	0	0	A	76045225	A	A	76045225	3	1	168	1	0	0	0	0	1	0	0	0	16408	1145	40	1	84	1	TNRC6C	17	76045225	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	3129508	76045225	5149985	149	31700											
FAM59A	64762	broad.mit.edu	37	chr18	29847915	29847915	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aatttgaaatcctctgagagGatttcttccgttagctgaac	11	14	8	8	1	2	3	0	3	2	1	4	5	4	4	2	1	2	2	2	1	4	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr18:29847915G>C	uc002kxl.2	-	6	2606	c.2550C>G	c.(2548-2550)ATC>ATG	p.I850M	FAM59A_uc002kxk.1_Missense_Mutation_p.I849M	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	850	SAM.									ovary(1)|skin(1)	2						CCTCTGAGAGGATTTCTTCCG	0.418													6	34					0	0	0	0	C	29847915	C	C	29847915	3	2	168	1	0	0	0	0	1	0	0	0	5624	1164	41	2	84	2	FAM59A	18	29847915	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08		29847915	48229333	150	31701											
ALPK2	115701	broad.mit.edu	37	chr18	56184167	56184167	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcgagtttgtagttcctttgGatgagctcatcattatttct	7	18	9	7	1	3	1	2	1	1	0	4	3	4	2	1	1	1	4	1	1	2	6	rs61732436		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr18:56184167G>T	uc002lhj.3	-	9	6127	c.5913C>A	c.(5911-5913)ATC>ATA	p.I1971I		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1971	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						AGTTCCTTTGGATGAGCTCAT	0.502													18	73					2.37509e-13	2.72831e-13	1	0	T	56184167	T	T	56184167	2	4	168	1	0	0	0	0	0	0	0	1	545	1164	41	2		2	ALPK2	18	56184167	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	26336252	56184167	21893081	151	31702											
MC4R	4160	broad.mit.edu	37	chr18	58038766	58038766	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcacacacaatatggattctGaggacaagagatgtagaata	17	8	10	6	0	1	3	0	1	1	2	1	6	1	5	0	2	0	2	0	2	6	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr18:58038766G>A	uc002lie.1	-	1	1236	c.817C>T	c.(817-819)CAG>TAG	p.Q273*		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	273	Extracellular (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				TATGGATTCTGAGGACAAGAG	0.423													13	51					0	0	0	0	A	58038766	A	A	58038766	4	1	168	1	0	0	0	0	0	1	0	0	9419	1299	45	2	185	2	MC4R	18	58038766	Nonsense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	1854599	58038766	20038482	152	31703											
C19orf36	113177	broad.mit.edu	37	chr19	2096977	2096977	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcctggtgtgcctgacGgcggcgctggcccacggctg	2	8	17	14	4	0	1	0	1	0	0	0	1	0	1	3	5	2	2	3	5	0	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:2096977G>T	uc002luw.1	+	1	110	c.33G>T	c.(31-33)ACG>ACT	p.T11T	C19orf36_uc002lux.1_Silent_p.T11T|C19orf36_uc010xgw.1_Silent_p.T11T|MOBKL2A_uc002luv.2_5'Flank	NM_001039846	NP_001034935	Q1ZYL8	IZUM4_HUMAN	hypothetical protein LOC113177 isoform 3	11						extracellular region					0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCCTGACGGCGGCGCTGG	0.672											OREG0025135	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	61					0.000978159	0.00100971	1	0	T	2096977	T	T	2096977	2	4	168	1	0	0	0	0	0	0	0	1	1930	1103	39	3		3	C19orf36	19	2096977	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08		2096977	57032006	153	31704											
CREB3L3	84699	broad.mit.edu	37	chr19	4171169	4171169	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccagacaggcacctgtgtCgcagtgagtcctggtgcccc	6	7	13	15	1	0	2	0	1	0	1	2	2	1	2	5	2	1	2	5	2	0	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:4171169C>T	uc002lzl.2	+	8	1088	c.972C>T	c.(970-972)GTC>GTT	p.V324V	CREB3L3_uc002lzm.2_Silent_p.V314V|CREB3L3_uc010xib.1_Silent_p.V313V|CREB3L3_uc010xic.1_Missense_Mutation_p.R280C	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	324	Helical; Signal-anchor for type II membrane protein; (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACCTGTGTCGCAGTGAGTC	0.602													21	23					0	0	0	0	T	4171169	T	T	4171169	2	4	168	1	0	0	0	0	0	0	0	1	3873	871	31	1		1	CREB3L3	19	4171169	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	2074192	4171169	54957814	154	31705											
FDX1L	112812	broad.mit.edu	37	chr19	10426650	10426650	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaaccctggcactcacgcctCcccgggccatggaggcggcc	6	4	13	18	3	1	0	1	0	0	0	2	2	2	1	6	5	1	1	6	5	1	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:10426650C>T	uc002mny.1	-	1	42	c.23G>A	c.(22-24)GGA>GAA	p.G8E	FDX1L_uc002mnx.1_RNA	NM_001031734	NP_001026904	Q6P4F2	ADXL_HUMAN	ferredoxin 1-like precursor	8					electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(20;9.5e-10)|Epithelial(33;2.11e-06)|all cancers(31;5.06e-06)			ACTCACGCCTCCCCGGGCCAT	0.662													3	13					0	0	0	0	T	10426650	T	T	10426650	3	4	168	1	0	0	0	0	1	0	0	0	5837	855	30	2	548	2	FDX1L	19	10426650	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	6255481	10426650	48702333	155	31706											
LDLR	3949	broad.mit.edu	37	chr19	11224240	11224240	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacagagcccacggcgtctCttcctatgacaccgtcatca	9	9	8	15	3	3	3	2	2	1	1	5	3	4	3	3	1	1	0	3	1	1	2			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:11224240C>G	uc002mqk.3	+	10	1556	c.1388C>G	c.(1387-1389)TCT>TGT	p.S463C	LDLR_uc010xlk.1_Missense_Mutation_p.S463C|LDLR_uc010xll.1_Missense_Mutation_p.S422C|LDLR_uc010xlm.1_Missense_Mutation_p.S316C|LDLR_uc010xln.1_Missense_Mutation_p.S336C|LDLR_uc010xlo.1_Missense_Mutation_p.S295C	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	463	LDL-receptor class B 2.|Extracellular (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CACGGCGTCTCTTCCTATGAC	0.632													10	27					0	0	0	0	G	11224240	G	G	11224240	3	3	168	1	0	0	0	0	1	0	0	0	8744	913	32	2	1426	2	LDLR	19	11224240	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	797590	11224240	47904743	156	31707											
ZNF208	7757	broad.mit.edu	37	chr19	22157311	22157311	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatgatctgacgtattctttAcattgcaaatgtttctttcc	10	18	5	8	1	3	2	0	2	3	0	4	2	4	2	1	0	2	3	1	0	4	7			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:22157311A>C	uc002nqp.2	-	4	674	c.525T>G	c.(523-525)TGT>TGG	p.C175W	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CGTATTCTTTACATTGCAAAT	0.328													8	41					0	0	0	0	C	22157311	C	C	22157311	3	2	168	1	0	0	0	0	1	0	0	0	17833	389	14	5	3321	5	ZNF208	19	22157311	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08	10933071	22157311	36971672	157	31708											
ZNF675	171392	broad.mit.edu	37	chr19	23836955	23836955	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggttaaaggctttgccacaTtcttcacatttgtatggttt	8	18	8	7	0	2	0	1	0	1	0	2	0	2	0	1	3	1	4	1	3	3	7			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:23836955T>C	uc002nri.2	-	4	962	c.780A>G	c.(778-780)GAA>GAG	p.E260E		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	260	C2H2-type 5.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CTTTGCCACATTCTTCACATT	0.353													10	31					0	0	0	0	C	23836955	C	C	23836955	2	2	168	1	0	0	0	0	0	0	0	1	18149	1490	52	5		5	ZNF675	19	23836955	Silent	SNP	T	TCGA-CV-5430-01A-02D-1683-08	1679644	23836955	35292028	158	31709											
FCGBP	8857	broad.mit.edu	37	chr19	40376315	40376315	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgactaggttcctacctCatagtagacaccattgtggt	11	12	9	9	0	1	3	1	1	0	2	2	3	2	3	3	2	1	2	3	2	4	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:40376315C>G	uc002omp.3	-	25	11997	c.11989G>C	c.(11989-11991)GAG>CAG	p.E3997Q		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	3997	Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GTTCCTACCTCATAGTAGACA	0.532													6	28					0	0	0	0	G	40376315	G	G	40376315	3	3	168	1	0	0	0	0	1	0	0	0	5810	835	29	2	4276	2	FCGBP	19	40376315	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	16539360	40376315	18752668	159	31710											
ZNF155	7711	broad.mit.edu	37	chr19	44501449	44501450	+	Frame_Shift_Ins	INS	-	A	A																															ataagagactccactgccagINSaaaaaaccattcaaatgtga																										TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:44501449_44501450insA	uc002oxy.1	+	5	1645_1646	c.1440_1441insA	c.(1438-1443)CAGAAAfs	p.Q480fs	ZNF155_uc002oxz.1_Frame_Shift_Ins_p.Q480fs|ZNF155_uc010xwt.1_Frame_Shift_Ins_p.Q491fs|uc010ejc.1_RNA	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	480_481						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				TCCACTGCCAGAAAAAACCATT	0.455													---	---	---								A	44501450	A	A	44501449	7	5	168	1	0	1	1	0	0	0	0	0	17803	933	33	0	1454	0	ZNF155	19	44501449	Frame_Shift_Ins	INS	-	TCGA-CV-5430-01A-02D-1683-08	4125134	44501449	14627534	160	31711											
BCAM	4059	broad.mit.edu	37	chr19	45316587	45316587	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcagcgcctggaggtgccCgtagagatgaacccaggtga	9	5	17	10	2	0	3	0	2	0	1	0	5	0	4	3	4	3	2	3	4	2	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:45316587C>G	uc002ozu.2	+	5	629	c.585C>G	c.(583-585)CCC>CCG	p.P195P	BCAM_uc002ozt.1_Silent_p.P195P	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	195	Extracellular (Potential).|Ig-like V-type 2.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				TGGAGGTGCCCGTAGAGATGA	0.687													18	41					0	0	0	0	G	45316587	G	G	45316587	2	3	168	1	0	0	0	0	0	0	0	1	1346	639	23	3		3	BCAM	19	45316587	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	815138	45316587	13812396	161	31712											
IZUMO1	284359	broad.mit.edu	37	chr19	49245052	49245052	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacagcactgacctgtgaCgtgaaaattgatgatcgtgg	11	9	11	10	2	0	5	0	5	0	0	1	5	0	5	2	1	1	1	2	1	2	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:49245052C>T	uc002pkj.2	-	8	1296	c.748G>A	c.(748-750)GTC>ATC	p.V250I	RASIP1_uc002pki.2_5'Flank|IZUMO1_uc010eme.2_RNA|IZUMO1_uc010emf.2_RNA	NM_182575	NP_872381	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1 precursor	250	Ig-like C2-type.|Extracellular (Potential).				fusion of sperm to egg plasma membrane	integral to membrane				ovary(1)	1		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TGACCTGTGACGTGAAAATTG	0.632													9	27					0	0	0	0	T	49245052	T	T	49245052	3	4	168	1	0	0	0	0	1	0	0	0	7972	536	19	1	316	1	IZUMO1	19	49245052	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	3928465	49245052	9883931	162	31713											
IL4I1	259307	broad.mit.edu	37	chr19	50399101	50399101	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatcgctgagcaccttggCggccaccagcccggccacac	8	4	11	18	3	0	1	0	1	0	0	1	1	0	1	5	3	3	3	5	3	0	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:50399101C>T	uc002pqt.1	-	3	301	c.223G>A	c.(223-225)GCC>ACC	p.A75T	IL4I1_uc002pqv.1_Missense_Mutation_p.A84T|IL4I1_uc010eno.1_Missense_Mutation_p.A83T|IL4I1_uc002pqw.1_Missense_Mutation_p.A83T|IL4I1_uc002pqu.1_Missense_Mutation_p.A97T	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	75						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		AGCACCTTGGCGGCCACCAGC	0.637													12	116					0	0	0	0	T	50399101	T	T	50399101	3	4	168	1	0	0	0	0	1	0	0	0	7736	768	27	1	1504	1	IL4I1	19	50399101	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	1154049	50399101	8729882	163	31714											
ZNF616	90317	broad.mit.edu	37	chr19	52619847	52619847	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgctttaaaggctttgccAcattcattacatacatacgt	12	13	6	10	2	1	0	1	0	0	0	1	1	1	0	1	1	4	2	1	1	5	7			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr19:52619847A>G	uc002pym.2	-	4	853	c.570T>C	c.(568-570)TGT>TGC	p.C190C	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	190	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		AGGCTTTGCCACATTCATTAC	0.373													41	83					0	0	0	0	G	52619847	G	G	52619847	2	3	168	1	0	0	0	0	0	0	0	1	18108	157	6	5		5	ZNF616	19	52619847	Silent	SNP	A	TCGA-CV-5430-01A-02D-1683-08	2220746	52619847	6509136	164	31715											
TMC2	117532	broad.mit.edu	37	chr20	2621930	2621930	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcggaccagattctggccAcgccccatctcagactcatc	10	8	7	16	2	3	2	2	0	2	2	6	3	3	3	4	2	0	0	4	2	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr20:2621930A>G	uc002wgf.1	+	20	2669	c.2654A>G	c.(2653-2655)CAC>CGC	p.H885R	TMC2_uc002wgg.1_Missense_Mutation_p.H869R	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	885	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GATTCTGGCCACGCCCCATCT	0.617													3	47					0	0	0	0	G	2621930	G	G	2621930	3	3	168	1	0	0	0	0	1	0	0	0	16051	159	6	5	2732	5	TMC2	20	2621930	Missense_Mutation	SNP	A	TCGA-CV-5430-01A-02D-1683-08		2621930	60403590	165	31716											
ESF1	51575	broad.mit.edu	37	chr20	13698017	13698017	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggtgtctatggttacctCaaagtcatcctctattaatt	9	16	6	10	0	4	0	2	0	2	0	5	0	5	0	3	2	1	1	3	2	5	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr20:13698017C>G	uc002woj.2	-	13	2368	c.2260G>C	c.(2260-2262)GAG>CAG	p.E754Q		NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	754	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						ATGGTTACCTCAAAGTCATCC	0.279													15	854					0	0	0	0	G	13698017	G	G	13698017	3	3	168	1	0	0	0	0	1	0	0	0	5275	835	29	2	303	2	ESF1	20	13698017	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	11076087	13698017	49327503	166	31717											
ESF1	51575	broad.mit.edu	37	chr20	13753183	13753183	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctttttctggggcatcttCaggaatacttaatagctcta	9	16	8	8	0	5	0	1	0	4	0	5	1	5	1	0	3	2	2	0	3	5	7			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr20:13753183C>T	uc002woj.2	-	5	1336	c.1228G>A	c.(1228-1230)GAA>AAA	p.E410K	ESF1_uc002wok.1_Missense_Mutation_p.E410K	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						GGGGCATCTTCAGGAATACTT	0.343													17	844					0	0	0	0	T	13753183	T	T	13753183	3	4	168	1	0	0	0	0	1	0	0	0	5275	835	29	2	1367	2	ESF1	20	13753183	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	55166	13753183	49272337	167	31718											
ENTPD6	955	broad.mit.edu	37	chr20	25199204	25199204	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctacctcgggctcgggctGatgtcggcacgcctggcgat	5	8	15	13	5	0	1	0	1	0	0	3	2	0	1	2	4	2	4	2	4	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr20:25199204G>A	uc002wuj.2	+	10	1077	c.897G>A	c.(895-897)CTG>CTA	p.L299L	ENTPD6_uc010zsy.1_Silent_p.L299L|ENTPD6_uc010gdj.1_Silent_p.L271L|ENTPD6_uc010zsz.1_Silent_p.L81L|ENTPD6_uc002wum.2_Silent_p.L282L|ENTPD6_uc010zta.1_Silent_p.L299L|ENTPD6_uc002wun.2_Silent_p.L299L|ENTPD6_uc002wuk.2_Silent_p.L298L|ENTPD6_uc002wul.2_Silent_p.L298L|ENTPD6_uc010ztb.1_Silent_p.L271L|ENTPD6_uc010ztc.1_Silent_p.L271L|ENTPD6_uc002wuo.2_Silent_p.L51L|ENTPD6_uc010ztd.1_Silent_p.L81L	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	299	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						GGCTCGGGCTGATGTCGGCAC	0.657													6	9					0	0	0	0	A	25199204	A	A	25199204	2	1	168	1	0	0	0	0	0	0	0	1	5167	1277	45	2		2	ENTPD6	20	25199204	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	11446021	25199204	37826316	168	31719											
CDH4	1002	broad.mit.edu	37	chr20	60511842	60511842	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acggcacccccctatgactcCctgctggtcttcgactacga	7	9	8	17	3	1	1	0	1	1	0	3	3	2	1	4	2	2	2	4	2	2	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr20:60511842C>T	uc002ybn.1	+	16	2606	c.2592C>T	c.(2590-2592)TCC>TCT	p.S864S	CDH4_uc002ybp.1_Silent_p.S790S|uc002ybr.1_5'Flank	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	864	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CCTATGACTCCCTGCTGGTCT	0.637													22	22					0	0	0	0	T	60511842	T	T	60511842	2	4	168	1	0	0	0	0	0	0	0	1	3127	610	22	4		4	CDH4	20	60511842	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08	35312638	60511842	2513678	169	31720											
RNF160	26046	broad.mit.edu	37	chr21	30357237	30357237	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcttctcggacgcgacggtCatgatcctattaaaaatata	12	11	9	9	4	2	1	1	1	1	0	4	3	3	2	1	3	0	1	1	3	6	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr21:30357237C>T	uc002ymr.2	-	4	503	c.490G>A	c.(490-492)GAC>AAC	p.D164N	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	118							ligase activity|zinc ion binding				0						ACGCGACGGTCATGATCCTAT	0.348													10	17					0	0	0	0	T	30357237	T	T	30357237	3	4	168	1	0	0	0	0	1	0	0	0	13520	826	29	2	5056	2	RNF160	21	30357237	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08		30357237	17772658	170	31721											
DONSON	29980	broad.mit.edu	37	chr21	34950680	34950680	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagatgatttcccaagtaacGgtatttgactaagttgctcc	12	13	8	8	1	0	3	0	2	0	1	2	3	2	3	2	1	2	4	2	1	5	6			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr21:34950680G>C	uc002ysk.2	-	10	1701	c.1634C>G	c.(1633-1635)CCG>CGG	p.P545R	DONSON_uc002ysi.1_Missense_Mutation_p.P305R|DONSON_uc002ysj.2_Missense_Mutation_p.P178R|DONSON_uc002ysl.2_Missense_Mutation_p.P178R|DONSON_uc010gme.2_Missense_Mutation_p.P518R|DONSON_uc002ysm.2_Missense_Mutation_p.P545R	NM_017613	NP_060083	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	545					multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2						CCCAAGTAACGGTATTTGACT	0.403													9	71					0	0	0	0	C	34950680	C	C	34950680	3	2	168	1	0	0	0	0	1	0	0	0	4728	1116	39	3	70	3	DONSON	21	34950680	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	4593443	34950680	13179215	171	31722											
EWSR1	2130	broad.mit.edu	37	chr22	29695245	29695245	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggttgtggaaaccagaacttCgcctggagaacagagtgcaa	13	7	13	8	1	0	3	0	0	0	3	1	5	0	4	2	3	4	2	2	3	4	2	rs138837921		TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr22:29695245C>T	uc003aet.2	+	15	1930	c.1602C>T	c.(1600-1602)TTC>TTT	p.F534F	EWSR1_uc003aev.2_Silent_p.F539F|EWSR1_uc003aew.2_Silent_p.F478F|EWSR1_uc003aex.2_Silent_p.F533F|EWSR1_uc003aey.2_Silent_p.F329F|EWSR1_uc003aez.2_Silent_p.F195F	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	534	RanBP2-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						ACCAGAACTTCGCCTGGAGAA	0.512			T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								27	102					0	0	0	0	T	29695245	T	T	29695245	2	4	168	1	0	0	0	0	0	0	0	1	5320	883	31	1		1	EWSR1	22	29695245	Silent	SNP	C	TCGA-CV-5430-01A-02D-1683-08		29695245	21609321	172	31723											
TBC1D10A	83874	broad.mit.edu	37	chr22	30722697	30722697	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcgagcccacgatgaagccGaacttgtcgatgcggcgctc	8	7	13	13	6	0	1	0	1	0	0	2	5	0	1	2	1	5	1	2	1	2	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chr22:30722697G>A	uc011akt.1	-	1	198	c.174C>T	c.(172-174)TTC>TTT	p.F58F	TBC1D10A_uc010gvu.2_Silent_p.F58F|TBC1D10A_uc003ahk.3_Silent_p.F58F	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	58						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CGATGAAGCCGAACTTGTCGA	0.726													10	24					0	0	0	0	A	30722697	A	A	30722697	2	1	168	1	0	0	0	0	0	0	0	1	15664	1049	37	1		1	TBC1D10A	22	30722697	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	1027452	30722697	20581869	173	31724											
PHKA2	5256	broad.mit.edu	37	chrX	18912411	18912411	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtcatctccgtgtccgagaGcagcgtcagcaccatgatgg	8	8	13	12	3	3	2	2	1	1	1	5	3	4	2	3	2	3	2	3	2	0	0			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:18912411G>A	uc004cyv.3	-	32	3878	c.3448C>T	c.(3448-3450)CTC>TTC	p.L1150F	uc004cyt.2_RNA|PHKA2_uc004cyu.3_Missense_Mutation_p.L456F|PHKA2_uc010nfe.1_Missense_Mutation_p.L182F|PHKA2_uc010nff.1_RNA	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1150					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					GTGTCCGAGAGCAGCGTCAGC	0.612													28	12					0	0	0	0	A	18912411	A	A	18912411	3	1	168	1	0	0	0	0	1	0	0	0	11899	971	34	4	267	4	PHKA2	23	18912411	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08		18912411	136358149	174	31725											
RBM10	8241	broad.mit.edu	37	chrX	47030561	47030563	+	In_Frame_Del	DEL	GGA	-	-																															gactatcggaccgagcaaggGgaggaggaggaggaggagga																										TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:47030561_47030563delGGA	uc004dhf.2	+	4	715_717	c.336_338delGGA	c.(334-339)GGGGAG>GGG	p.E119del	RBM10_uc004dhe.1_In_Frame_Del_p.E109del|RBM10_uc004dhg.2_Intron|RBM10_uc004dhh.2_In_Frame_Del_p.E119del|RBM10_uc010nhq.2_Intron|RBM10_uc004dhi.2_In_Frame_Del_p.E184del	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	119	Poly-Glu.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						CCGAGCAAGGggaggaggaggag	0.522													---	---	---								-	47030563	-	-	47030561	7	5	168	1	0	1	0	1	0	0	0	0	13176	1219	43	0	346	0	RBM10	23	47030561	In_Frame_Del	DEL	GGA	TCGA-CV-5430-01A-02D-1683-08	28118150	47030561	108239999	175	31726											
TAF7L	54457	broad.mit.edu	37	chrX	100547854	100547854	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatccgtttgagtgtcctcGtcggcaggaatctgggtgcc	5	11	14	11	3	1	1	0	1	1	0	5	2	3	2	3	3	1	3	3	3	1	1			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:100547854G>A	uc004ehb.2	-	1	192	c.180C>T	c.(178-180)GAC>GAT	p.D60D	TAF7L_uc004ehc.1_5'Flank	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	60					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						GAGTGTCCTCGTCGGCAGGAA	0.562													7	175					0	0	0	0	A	100547854	A	A	100547854	2	1	168	1	0	0	0	0	0	0	0	1	15599	1136	40	1		1	TAF7L	23	100547854	Silent	SNP	G	TCGA-CV-5430-01A-02D-1683-08	53517293	100547854	54722706	176	31727											
ODZ1	10178	broad.mit.edu	37	chrX	123870838	123870838	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtatgttgctgttcaggaCccagctgttatgcagatgga	8	13	13	7	0	1	1	1	0	0	1	1	3	1	3	1	3	3	7	1	3	2	4			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:123870838C>G	uc004euj.2	-	4	809	c.745G>C	c.(745-747)GTC>CTC	p.V249L	ODZ1_uc011muj.1_Missense_Mutation_p.V249L|ODZ1_uc010nqy.2_Missense_Mutation_p.V249L	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	249	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTGTTCAGGACCCAGCTGTTA	0.502													168	88					0	0	0	0	G	123870838	G	G	123870838	3	3	168	1	0	0	0	0	1	0	0	0	10888	507	18	4	7569	4	ODZ1	23	123870838	Missense_Mutation	SNP	C	TCGA-CV-5430-01A-02D-1683-08	23322984	123870838	31399722	177	31728											
IGSF1	3547	broad.mit.edu	37	chrX	130409627	130409627	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtggcttctccttctttGtgcagaatgtatcctactcc	7	15	8	11	0	2	1	0	0	2	1	5	2	4	1	3	1	2	3	3	1	4	5			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:130409627G>T	uc004ewd.2	-	16	3247	c.3009C>A	c.(3007-3009)CAC>CAA	p.H1003Q	IGSF1_uc004ewe.3_Missense_Mutation_p.H997Q|IGSF1_uc004ewf.2_Missense_Mutation_p.H983Q	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1003	Extracellular (Potential).|Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CTCCTTCTTTGTGCAGAATGT	0.527													11	71					2.35188e-11	2.67422e-11	1	0	T	130409627	T	T	130409627	3	4	168	1	0	0	0	0	1	0	0	0	7635	1368	48	4	1021	4	IGSF1	23	130409627	Missense_Mutation	SNP	G	TCGA-CV-5430-01A-02D-1683-08	6538789	130409627	24860933	178	31729											
MAGEA11	4110	broad.mit.edu	37	chrX	148798058	148798058	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttatgatggcatacagtgTaatgagcagagcatgcccaa	13	10	10	8	0	1	3	0	2	1	1	1	3	1	3	1	1	4	4	1	1	4	3			TCGA-CV-5430-01A-02D-1683-08	TCGA-CV-5430-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dfcbe35-9e78-4629-8a00-96fee7062d1e	e879b6a8-15e5-434f-9d46-71e58b6d25c8	g.chrX:148798058T>C	uc004fdq.2	+	5	1014	c.912T>C	c.(910-912)TGT>TGC	p.C304C	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Silent_p.C275C	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	304	MAGE.					cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GCATACAGTGTAATGAGCAGA	0.502													23	101					0	0	0	0	C	148798058	C	C	148798058	2	2	168	1	0	0	0	0	0	0	0	1	9216	1644	57	5		5	MAGEA11	23	148798058	Silent	SNP	T	TCGA-CV-5430-01A-02D-1683-08	18388431	148798058	6472502	179	31730											
PAX7	5081	broad.mit.edu	37	chr1	19029673	19029673	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcagcggctgcagccgcCgacaccagctctgcctacgg	6	5	13	17	4	1	0	0	0	1	0	1	1	1	0	4	2	7	5	4	2	1	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:19029673C>T	uc001bay.2	+	7	1636	c.1038C>T	c.(1036-1038)GCC>GCT	p.A346A	PAX7_uc001baz.2_Silent_p.A344A|PAX7_uc010oct.1_Silent_p.A346A	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	346	Poly-Ala.				anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		CTGCAGCCGCCGACACCAGCT	0.667			T	FOXO1A	alveolar rhabdomyosarcoma								4	16					0	0	0	0	T	19029673	T	T	19029673	2	4	169	1	0	0	0	0	0	0	0	1	11538	639	23	1		1	PAX7	1	19029673	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08		19029673	230220948	1	31731											
TMEM39B	55116	broad.mit.edu	37	chr1	32542920	32542920	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgttcctctgctatccGtgagtacccctcacttcacc	5	13	5	18	1	3	1	2	1	1	0	6	1	6	1	6	0	2	3	6	0	2	4			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:32542920G>A	uc010ogv.1	+	5	736	c.590_splice	c.e5+1	p.P197_splice	TMEM39B_uc010ogt.1_Intron|TMEM39B_uc010ogu.1_Splice_Site_p.P70_splice|TMEM39B_uc001bue.3_Splice_Site_p.P197_splice|TMEM39B_uc001buf.3_Intron|TMEM39B_uc010ogw.1_Intron	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B							integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TCTGCTATCCGTGAGTACCCC	0.597													19	75					0	0	0	0	A	32542920	A	A	32542920	5	1	169	1	0	0	0	0	0	0	1	0	16228	1159	40	1	609	1	TMEM39B	1	32542920	Splice_Site	SNP	G	TCGA-CV-5431-01A-01D-1512-08	13513247	32542920	216707701	2	31732											
RIMKLA	284716	broad.mit.edu	37	chr1	42880192	42880192	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccgctgacagaacaaggCaagcagttggctattcaggt	11	9	12	9	1	1	2	1	1	0	1	2	2	2	2	1	3	2	5	1	3	4	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:42880192C>T	uc001chi.2	+	5	861	c.723C>T	c.(721-723)GGC>GGT	p.G241G		NM_173642	NP_775913	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family	241	ATP-grasp.				protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CAGAACAAGGCAAGCAGTTGG	0.502													60	351					0	0	0	0	T	42880192	T	T	42880192	2	4	169	1	0	0	0	0	0	0	0	1	13430	697	25	4		4	RIMKLA	1	42880192	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	10337272	42880192	206370429	3	31733											
ELOVL1	64834	broad.mit.edu	37	chr1	43830980	43830980	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtgagagaacgaagtacacGtaggtcaggagaatggaggt	15	6	16	4	2	1	3	1	1	0	2	1	7	1	4	0	4	2	2	0	4	5	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:43830980G>A	uc001ciz.2	-	4	357	c.114C>T	c.(112-114)TAC>TAT	p.Y38Y	ELOVL1_uc001cja.2_Silent_p.Y38Y|ELOVL1_uc001cjb.2_Silent_p.Y38Y|ELOVL1_uc001cjc.2_RNA|ELOVL1_uc010okh.1_Silent_p.Y38Y	NM_022821	NP_073732	Q9BW60	ELOV1_HUMAN	elongation of very long chain fatty acids-like	38	Helical; (Potential).				fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|sphingolipid biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	fatty acid elongase activity|protein binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CGAAGTACACGTAGGTCAGGA	0.527													14	40					0	0	0	0	A	43830980	A	A	43830980	2	1	169	1	0	0	0	0	0	0	0	1	5097	1140	40	1		1	ELOVL1	1	43830980	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08	950788	43830980	205419641	4	31734											
LRRC8D	55144	broad.mit.edu	37	chr1	90400812	90400812	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagtggcagtatttagtttaCagaaactcagatgcttagat	13	13	9	6	0	1	3	1	0	0	3	1	3	1	3	0	1	3	4	0	1	5	6			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:90400812C>T	uc001dnm.2	+	3	2610	c.2185C>T	c.(2185-2187)CAG>TAG	p.Q729*	LRRC8D_uc001dnn.2_Nonsense_Mutation_p.Q729*	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	729						integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		ATTTAGTTTACAGAAACTCAG	0.378													22	140					0	0	0	0	T	90400812	T	T	90400812	4	4	169	1	0	0	0	0	0	1	0	0	9074	479	17	4	2187	4	LRRC8D	1	90400812	Nonsense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	46569832	90400812	158849809	5	31735											
S100A7A	338324	broad.mit.edu	37	chr1	153390659	153390659	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagaagccaagcctgctgaCgatgatgaaggagaacttcc	13	7	12	9	1	0	5	0	4	0	2	1	8	1	5	3	1	4	1	3	1	4	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:153390659C>T	uc001fbt.1	+	2	158	c.101C>T	c.(100-102)ACG>ATG	p.T34M		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	34	EF-hand 1.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGCCTGCTGACGATGATGAAG	0.483													81	190					0	0	0	0	T	153390659	T	T	153390659	3	4	169	1	0	0	0	0	1	0	0	0	13849	536	19	1	103	1	S100A7A	1	153390659	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	62989847	153390659	95859962	6	31736											
FCRL5	83416	broad.mit.edu	37	chr1	157514262	157514262	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctagagagagctgggtctCacaggtcagggtcactgggt	8	9	15	9	0	4	2	3	0	2	2	5	3	4	2	0	4	1	1	0	4	1	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:157514262C>T	uc001fqu.2	-	5	792	c.634G>A	c.(634-636)GAG>AAG	p.E212K	FCRL5_uc009wsm.2_Missense_Mutation_p.E212K|FCRL5_uc010phv.1_Missense_Mutation_p.E212K|FCRL5_uc010phw.1_Missense_Mutation_p.E127K|FCRL5_uc001fqv.1_Missense_Mutation_p.E212K|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	212	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AGCTGGGTCTCACAGGTCAGG	0.562													57	238					0	0	0	0	T	157514262	T	T	157514262	3	4	169	1	0	0	0	0	1	0	0	0	5830	835	29	2	2351	2	FCRL5	1	157514262	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	4123603	157514262	91736359	7	31737											
CD1A	909	broad.mit.edu	37	chr1	158226598	158226598	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagcccgaggcctggctgtcCcatggccccagtcctggccc	5	6	12	18	1	0	0	0	0	0	0	2	1	2	0	7	4	1	1	7	4	1	0			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:158226598C>G	uc001frt.2	+	4	1160	c.627C>G	c.(625-627)TCC>TCG	p.S209S		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	209	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	CCTGGCTGTCCCATGGCCCCA	0.522													37	178					0	0	0	0	G	158226598	G	G	158226598	2	3	169	1	0	0	0	0	0	0	0	1	2989	610	22	4		4	CD1A	1	158226598	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	712336	158226598	91024023	8	31738											
SPTA1	6708	broad.mit.edu	37	chr1	158615002	158615002	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aactccaggcactggtctagGatcttcttgcgtttttccca	7	14	8	12	1	3	0	0	0	3	0	5	1	5	1	2	3	2	2	2	3	2	5			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:158615002G>A	uc001fst.1	-	29	4369	c.4170C>T	c.(4168-4170)ATC>ATT	p.I1390I		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1390	Spectrin 13.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ACTGGTCTAGGATCTTCTTGC	0.438													46	300					0	0	0	0	A	158615002	A	A	158615002	2	1	169	1	0	0	0	0	0	0	0	1	15182	1164	41	2		2	SPTA1	1	158615002	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08	388404	158615002	90635619	9	31739											
DDR2	4921	broad.mit.edu	37	chr1	162748507	162748507	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actggagagttcttccgagaCcaagggaggcaggtaagaac	13	6	14	8	1	1	3	0	0	1	3	2	6	2	4	2	4	1	3	2	4	3	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:162748507C>T	uc001gcf.2	+	18	2886	c.2421C>T	c.(2419-2421)GAC>GAT	p.D807D	DDR2_uc001gcg.2_Silent_p.D807D	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	807	Cytoplasmic (Potential).|Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TCTTCCGAGACCAAGGGAGGC	0.498													23	135					0	0	0	0	T	162748507	T	T	162748507	2	4	169	1	0	0	0	0	0	0	0	1	4354	506	18	4		4	DDR2	1	162748507	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	4133505	162748507	86502114	10	31740											
ILDR2	387597	broad.mit.edu	37	chr1	166905901	166905901	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagctgtgagggcagcaCtggcaccagcagatccccac	10	4	12	15	0	0	2	0	1	0	1	1	2	1	2	3	2	4	6	3	2	0	0			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:166905901C>T	uc001gdx.1	-	5	686	c.630G>A	c.(628-630)CAG>CAA	p.Q210Q		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	210	Cys-rich.|Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						GAGGGCAGCACTGGCACCAGC	0.592													9	68					0	0	0	0	T	166905901	T	T	166905901	2	4	169	1	0	0	0	0	0	0	0	1	7749	564	20	4		4	ILDR2	1	166905901	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	4157394	166905901	82344720	11	31741											
FAIM3	9214	broad.mit.edu	37	chr1	207087230	207087230	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactaggaacagattcttgcGtgggtattgcttcagagtaa	11	12	11	7	1	2	2	1	0	1	2	2	3	2	3	0	2	3	3	0	2	4	7	rs138817695	byFrequency	TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:207087230G>A	uc001hey.2	-	2	426	c.247C>T	c.(247-249)CGC>TGC	p.R83C	FAIM3_uc010prz.1_Intron|FAIM3_uc010psa.1_Missense_Mutation_p.T26M|FAIM3_uc010psb.1_Missense_Mutation_p.R83C	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	83	Ig-like.|Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					AGATTCTTGCGTGGGTATTGC	0.537													27	220					0	0	0	0	A	207087230	A	A	207087230	3	1	169	1	0	0	0	0	1	0	0	0	5405	1145	40	1	953	1	FAIM3	1	207087230	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	40181329	207087230	42163391	12	31742											
ESRRG	2104	broad.mit.edu	37	chr1	216850620	216850620	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acaggcccactacctcccagGataggagcagaagggtagag	13	4	13	11	0	0	2	0	0	0	2	1	4	1	4	3	4	2	2	3	4	4	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:216850620G>C	uc001hkw.1	-	2	436	c.270C>G	c.(268-270)ATC>ATG	p.I90M	ESRRG_uc001hky.1_Missense_Mutation_p.I67M|ESRRG_uc009xdp.1_Missense_Mutation_p.I67M|ESRRG_uc001hkz.1_Missense_Mutation_p.I67M|ESRRG_uc010puc.1_Missense_Mutation_p.I67M|ESRRG_uc001hla.1_Missense_Mutation_p.I67M|ESRRG_uc001hlb.1_Missense_Mutation_p.I67M|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Missense_Mutation_p.I67M|ESRRG_uc001hld.1_Missense_Mutation_p.I67M|ESRRG_uc001hkx.1_Missense_Mutation_p.I95M|ESRRG_uc009xdo.1_Missense_Mutation_p.I67M|ESRRG_uc001hle.1_Missense_Mutation_p.I67M	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	90					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TACCTCCCAGGATAGGAGCAG	0.537													28	198					0	0	0	0	C	216850620	C	C	216850620	3	2	169	1	0	0	0	0	1	0	0	0	5286	1164	41	2	1130	2	ESRRG	1	216850620	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	9763390	216850620	32400001	13	31743											
OR11L1	391189	broad.mit.edu	37	chr1	248004602	248004602	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acggcaattgacaggatgaaGatggtcacctcggtgatata	13	9	12	7	2	1	4	1	3	0	1	2	5	1	5	1	4	0	1	1	4	4	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr1:248004602G>A	uc001idn.1	-	1	597	c.597C>T	c.(595-597)ATC>ATT	p.I199I		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			ACAGGATGAAGATGGTCACCT	0.483													29	180					0	0	0	0	A	248004602	A	A	248004602	2	1	169	1	0	0	0	0	0	0	0	1	10984	932	33	2		2	OR11L1	1	248004602	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08	31153982	248004602	1246019	14	31744											
NTSR2	23620	broad.mit.edu	37	chr2	11802234	11802234	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcactcagcagctccaggcGgctgggggtggagctgcccg	5	6	16	14	2	2	0	2	0	0	0	3	1	3	1	2	5	4	4	2	5	0	0	rs148798482	byFrequency	TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr2:11802234G>A	uc002rbq.3	-	2	831	c.757C>T	c.(757-759)CGC>TGC	p.R253C		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	253	Cytoplasmic (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	AGCTCCAGGCGGCTGGGGGTG	0.597													51	153					0	0	0	0	A	11802234	A	A	11802234	3	1	169	1	0	0	0	0	1	0	0	0	10765	1116	39	1	487	1	NTSR2	2	11802234	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08		11802234	231397139	15	31745											
ADCY3	109	broad.mit.edu	37	chr2	25059788	25059788	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgagccctgcacatacctGggcatcctgctcctcgggct	5	9	10	17	1	0	1	0	1	0	0	3	1	2	1	5	2	4	4	5	2	1	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr2:25059788G>A	uc002rfs.3	-	8	1859	c.1660C>T	c.(1660-1662)CAG>TAG	p.Q554*	ADCY3_uc002rfr.3_Nonsense_Mutation_p.Q187*|ADCY3_uc010ykm.1_Nonsense_Mutation_p.Q554*	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	554	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GCACATACCTGGGCATCCTGC	0.522													9	78					0	0	0	0	A	25059788	A	A	25059788	4	1	169	1	0	0	0	0	0	1	0	0	295	1357	47	4	1830	4	ADCY3	2	25059788	Nonsense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	13257554	25059788	218139585	16	31746											
DNAJC27	51277	broad.mit.edu	37	chr2	25170613	25170613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgatacgctttattgacttCatccctgggaaaagaagcca	12	10	8	11	2	1	2	1	1	0	1	2	4	2	3	3	1	2	1	3	1	5	5			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr2:25170613C>T	uc002rft.1	-	7	745	c.694G>A	c.(694-696)GAA>AAA	p.E232K	DNAJC27_uc010ykn.1_Missense_Mutation_p.E161K|DNAJC27_uc002rfu.1_RNA|DNAJC27_uc010eyg.1_Silent_p.*178*	NM_016544	NP_057628	Q9NZQ0	DJC27_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 27	232	J.				protein folding|small GTPase mediated signal transduction		GTP binding|heat shock protein binding|unfolded protein binding			skin(1)	1						TTATTGACTTCATCCCTGGGA	0.453													21	100					0	0	0	0	T	25170613	T	T	25170613	3	4	169	1	0	0	0	0	1	0	0	0	4667	835	29	2	131	2	DNAJC27	2	25170613	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	110825	25170613	218028760	17	31747											
TTC7A	57217	broad.mit.edu	37	chr2	47278895	47278895	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgctctgcaggctcccggcgGgcttcgtccatcgccgcctc	2	9	12	18	5	1	0	0	0	1	0	6	0	3	0	4	3	2	4	4	3	0	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr2:47278895G>A	uc002rvo.2	+	18	2396	c.2028G>A	c.(2026-2028)CGG>CGA	p.R676R	TTC7A_uc002rvm.2_Silent_p.R642R|TTC7A_uc010fbb.2_Silent_p.R700R|TTC7A_uc010fbc.2_Silent_p.R322R|TTC7A_uc002rvp.2_Silent_p.R557R|TTC7A_uc002rvq.2_Silent_p.R416R|TTC7A_uc002rvr.2_Silent_p.R125R	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	676							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GCTCCCGGCGGGCTTCGTCCA	0.667													17	105					0	0	0	0	A	47278895	A	A	47278895	2	1	169	1	0	0	0	0	0	0	0	1	16780	1219	43	4		4	TTC7A	2	47278895	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08	22108282	47278895	195920478	18	31748											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48809175	48809175	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagttgccgaagcgagatgAatcctattatgagaaggact	13	10	12	6	2	0	4	0	3	0	2	1	8	1	5	2	1	2	1	2	1	5	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr2:48809175A>T	uc010yol.1	+	1	1450	c.1403A>T	c.(1402-1404)GAA>GTA	p.E468V	STON1_uc002rwo.3_Missense_Mutation_p.E468V|STON1_uc010fbm.2_Missense_Mutation_p.E468V|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.E468V|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.E468V	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	468					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AAGCGAGATGAATCCTATTAT	0.373													32	197					0	0	0	0	T	48809175	T	T	48809175	3	4	169	1	0	0	0	0	1	0	0	0	15383	246	9	5	1405	5	STON1-GTF2A1L	2	48809175	Missense_Mutation	SNP	A	TCGA-CV-5431-01A-01D-1512-08	1530280	48809175	194390198	19	31749											
MYO7B	4648	broad.mit.edu	37	chr2	128387389	128387389	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccacggtcactaagccctcGgcacagctgctggtaactgg	8	7	11	15	2	1	0	1	0	0	0	2	0	1	0	2	4	4	4	2	4	2	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr2:128387389G>A	uc002top.2	+	34	4769	c.4716G>A	c.(4714-4716)TCG>TCA	p.S1572S	MYO7B_uc002tor.1_Silent_p.S425S	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1572						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTAAGCCCTCGGCACAGCTGC	0.642													9	43					0	0	0	0	A	128387389	A	A	128387389	2	1	169	1	0	0	0	0	0	0	0	1	10136	1103	39	1		1	MYO7B	2	128387389	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08	79578214	128387389	114811984	20	31750											
XIRP2	129446	broad.mit.edu	37	chr2	168105922	168105922	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcaatccaaatcagcttgcGaaattaaacaaagtcaccaa	18	8	5	10	1	2	0	2	0	0	0	3	1	3	0	2	0	4	2	2	0	7	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr2:168105922G>A	uc002udx.2	+	8	8038	c.8020G>A	c.(8020-8022)GAA>AAA	p.E2674K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E2499K|XIRP2_uc010fpq.2_Missense_Mutation_p.E2452K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.E20K	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2499					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATCAGCTTGCGAAATTAAACA	0.398													38	121					0	0	0	0	A	168105922	A	A	168105922	3	1	169	1	0	0	0	0	1	0	0	0	17498	1059	37	1	8050	1	XIRP2	2	168105922	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	39718533	168105922	75093451	21	31751											
TTN	7273	broad.mit.edu	37	chr2	179435824	179435824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacaatgattgcctctggcCgtcctggtggatcacatggg	7	11	13	10	1	2	2	1	2	1	0	3	3	3	3	3	4	1	0	3	4	1	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr2:179435824C>T	uc010zfg.1	-	275	67555	c.67331G>A	c.(67330-67332)CGG>CAG	p.R22444Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16139Q|TTN_uc010zfi.1_Missense_Mutation_p.R16072Q|TTN_uc010zfj.1_Missense_Mutation_p.R15947Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23371							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCCTCTGGCCGTCCTGGTGG	0.463													41	256					0	0	0	0	T	179435824	T	T	179435824	3	4	169	1	0	0	0	0	1	0	0	0	16803	652	23	1	33092	1	TTN	2	179435824	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	11329902	179435824	63763549	22	31752											
CXCR2	3579	broad.mit.edu	37	chr2	219000234	219000234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctacggattcaccctgcgtaCgctgtttaaggcccacatgg	8	10	10	13	3	1	0	1	0	0	0	1	1	1	1	2	3	3	3	2	3	3	5			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr2:219000234C>T	uc002vgz.1	+	4	935	c.710C>T	c.(709-711)ACG>ATG	p.T237M	CXCR2_uc002vha.1_Missense_Mutation_p.T237M|CXCR2_uc002vhb.1_Missense_Mutation_p.T237M	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	237	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						ACCCTGCGTACGCTGTTTAAG	0.577													54	312					0	0	0	0	T	219000234	T	T	219000234	3	4	169	1	0	0	0	0	1	0	0	0	4108	536	19	1	712	1	CXCR2	2	219000234	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	39564410	219000234	24199139	23	31753											
ANKZF1	55139	broad.mit.edu	37	chr2	220098637	220098637	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caagagctacagcgtgtgctCcataagctgaccactttgca	11	9	9	12	1	0	2	0	1	0	1	1	2	1	2	2	0	6	4	2	0	3	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr2:220098637C>T	uc002vkg.2	+	8	1194	c.1020C>T	c.(1018-1020)CTC>CTT	p.L340L	ANKZF1_uc010zkv.1_Silent_p.L284L|ANKZF1_uc010zkw.1_Silent_p.L130L|ANKZF1_uc002vkh.2_Silent_p.L130L|ANKZF1_uc002vki.2_Silent_p.L340L|ANKZF1_uc002vkj.1_Silent_p.L328L	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	340						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCGTGTGCTCCATAAGCTGA	0.557													12	61					0	0	0	0	T	220098637	T	T	220098637	2	4	169	1	0	0	0	0	0	0	0	1	693	842	30	2		2	ANKZF1	2	220098637	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	1098403	220098637	23100736	24	31754											
CNTN4	152330	broad.mit.edu	37	chr3	2924854	2924854	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgggtgaatatgagcccaaAatagaagtgcagttcccaga	15	8	11	7	0	0	4	0	2	0	2	1	4	1	4	2	1	2	2	2	1	6	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr3:2924854A>T	uc003bpc.2	+	8	899	c.678A>T	c.(676-678)AAA>AAT	p.K226N	CNTN4_uc003bpb.1_Intron|CNTN4_uc003bpd.1_Missense_Mutation_p.K226N	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	226	Ig-like C2-type 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ATGAGCCCAAAATAGAAGTGC	0.383													9	40					0	0	0	0	T	2924854	T	T	2924854	3	4	169	1	0	0	0	0	1	0	0	0	3658	11	1	5	700	5	CNTN4	3	2924854	Missense_Mutation	SNP	A	TCGA-CV-5431-01A-01D-1512-08		2924854	195097576	25	31755											
TTC21A	199223	broad.mit.edu	37	chr3	39170768	39170768	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacatctacctgcagacccTcagagacaggcgcctctaca	12	6	7	16	1	3	2	1	0	2	2	3	3	3	2	3	1	4	1	3	1	3	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr3:39170768T>G	uc003cjc.2	+	15	2300	c.2123T>G	c.(2122-2124)CTC>CGC	p.L708R	TTC21A_uc003cje.2_Missense_Mutation_p.L709R|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.L660R	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	708							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CTGCAGACCCTCAGAGACAGG	0.517													24	157					0	0	0	0	G	39170768	G	G	39170768	3	3	169	1	0	0	0	0	1	0	0	0	16755	1551	54	5	2184	5	TTC21A	3	39170768	Missense_Mutation	SNP	T	TCGA-CV-5431-01A-01D-1512-08	36245914	39170768	158851662	26	31756											
BSN	8927	broad.mit.edu	37	chr3	49691010	49691010	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgagttattcccgatgtcCgtgtcactcagcattttgca	7	13	9	12	3	2	0	2	0	0	0	4	2	4	0	3	0	2	3	3	0	1	4	rs142305207		TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr3:49691010C>T	uc003cxe.3	+	5	4135	c.4021C>T	c.(4021-4023)CGT>TGT	p.R1341C		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1341					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TCCCGATGTCCGTGTCACTCA	0.612													50	90					0	0	0	0	T	49691010	T	T	49691010	3	4	169	1	0	0	0	0	1	0	0	0	1535	652	23	1	4039	1	BSN	3	49691010	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	10520242	49691010	148331420	27	31757											
ITIH3	3699	broad.mit.edu	37	chr3	52841096	52841096	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgagcactttcagctggctgGacacagtcacagtcacgcag	10	7	11	13	2	3	0	3	0	0	0	3	2	3	1	0	2	2	4	0	2	0	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr3:52841096G>C	uc003dfv.2	+	19	2272	c.2236G>C	c.(2236-2238)GAC>CAC	p.D746H	ITIH3_uc011bek.1_Missense_Mutation_p.D554H	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	746					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CAGCTGGCTGGACACAGTCAC	0.418													3	12					0	0	0	0	C	52841096	C	C	52841096	3	2	169	1	0	0	0	0	1	0	0	0	7944	1174	41	2	2310	2	ITIH3	3	52841096	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	3150086	52841096	145181334	28	31758											
CEP97	79598	broad.mit.edu	37	chr3	101476041	101476042	+	Splice_Site	INS	-	T	T																															cagatatcccaggaaagtggINStaagaaatgaatttatctct																										TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr3:101476041_101476042insT	uc003dvk.1	+	8	1054	c.1027_splice	c.e8+1	p.E343_splice	CEP97_uc010hpm.1_Splice_Site_p.E309_splice|CEP97_uc011bhf.1_Splice_Site_p.E343_splice|CEP97_uc003dvl.1_Splice_Site_p.E39_splice|CEP97_uc003dvm.1_Splice_Site_p.E181_splice	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa							centrosome|nucleus	protein binding			ovary(2)	2						CAGGAAAGTGGTAAGAAATGAA	0.371													---	---	---								T	101476042	T	T	101476041	8	5	169	1	0	1	1	0	0	0	1	0	3278	1275	44	0	1058	0	CEP97	3	101476041	Splice_Site	INS	-	TCGA-CV-5431-01A-01D-1512-08	48634945	101476041	96546389	29	31759											
CD200R1L	344807	broad.mit.edu	37	chr3	112548233	112548233	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgcatgaactacttgaagcTagaaaacatttagagaagaa	19	9	8	5	0	0	5	0	2	0	3	0	6	0	5	0	0	5	2	0	0	9	5			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr3:112548233T>C	uc003dzi.1	-	2	273	c.47_splice	c.e2-1	p.A16_splice	CD200R1L_uc011bhw.1_Splice_Site|CD200R1L_uc010hqf.1_Splice_Site	NM_001008784	NP_001008784	Q6Q8B3	MO2R2_HUMAN	CD200 cell surface glycoprotein receptor 2							integral to membrane	receptor activity			ovary(1)	1						TACTTGAAGCTAGAAAACATT	0.373													31	75					0	0	0	0	C	112548233	C	C	112548233	5	2	169	1	0	0	0	0	0	0	1	0	2997	1536	53	5	790	5	CD200R1L	3	112548233	Splice_Site	SNP	T	TCGA-CV-5431-01A-01D-1512-08	11072192	112548233	85474197	30	31760											
KALRN	8997	broad.mit.edu	37	chr3	124418822	124418822	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttcagagtcagtgccagtaaCccctggggaatcagccttcc	9	9	10	13	0	3	1	3	0	0	1	4	2	4	2	5	2	3	1	5	2	2	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr3:124418822C>A	uc003ehg.2	+	56	8065	c.7938C>A	c.(7936-7938)AAC>AAA	p.N2646K	KALRN_uc003ehk.2_Missense_Mutation_p.N949K	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2645	Fibronectin type-III.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GTGCCAGTAACCCCTGGGGAA	0.582													73	238					1.52378e-38	1.66753e-38	1	0	A	124418822	A	A	124418822	3	1	169	1	0	0	0	0	1	0	0	0	8014	506	18	4	8316	4	KALRN	3	124418822	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	11870589	124418822	73603608	31	31761											
EIF2A	83939	broad.mit.edu	37	chr3	150289839	150289839	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgccaaagcgacaattttCaacttgaaatgtgatcctgt	12	12	7	10	1	1	2	1	2	0	0	2	3	2	2	3	0	3	0	3	0	4	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr3:150289839C>T	uc003eya.2	+	10	922	c.906C>T	c.(904-906)TTC>TTT	p.F302F	SERP1_uc003exz.2_Intron|EIF2A_uc003eyb.2_Silent_p.F175F|EIF2A_uc003eyc.2_Silent_p.F175F|EIF2A_uc011bnv.1_Silent_p.F277F|EIF2A_uc011bnw.1_Silent_p.F241F|EIF2A_uc003eyd.2_Silent_p.F77F|uc003eye.1_Intron	NM_032025	NP_114414	Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A	302					regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding				0		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CGACAATTTTCAACTTGAAAT	0.378													12	68					0	0	0	0	T	150289839	T	T	150289839	2	4	169	1	0	0	0	0	0	0	0	1	5017	825	29	2		2	EIF2A	3	150289839	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	25871017	150289839	47732591	32	31762											
DRD5	1816	broad.mit.edu	37	chr4	9783799	9783799	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caccgcctgcctgctgacccTactcatcatctggaccctgc	6	9	7	19	1	3	1	2	1	1	0	3	2	3	2	5	1	4	1	5	1	1	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr4:9783799T>A	uc003gmb.3	+	1	542	c.146T>A	c.(145-147)CTA>CAA	p.L49Q		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	49	Helical; Name=1; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CTGCTGACCCTACTCATCATC	0.677													7	23					0	0	0	0	A	9783799	A	A	9783799	3	1	169	1	0	0	0	0	1	0	0	0	4782	1522	53	5	148	5	DRD5	4	9783799	Missense_Mutation	SNP	T	TCGA-CV-5431-01A-01D-1512-08		9783799	181370477	33	31763											
MUC7	4589	broad.mit.edu	37	chr4	71346528	71346528	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctgcagttcagtgaaggtCgagaaagggatcatgaacta	13	10	12	6	1	3	3	2	2	1	1	4	5	3	4	0	2	2	2	0	2	4	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr4:71346528C>T	uc011cat.1	+	4	355	c.67C>T	c.(67-69)CGA>TGA	p.R23*	MUC7_uc011cau.1_Nonsense_Mutation_p.R23*|MUC7_uc003hfj.2_Nonsense_Mutation_p.R23*	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	23						extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			CAGTGAAGGTCGAGAAAGGGA	0.249													20	162					0	0	0	0	T	71346528	T	T	71346528	4	4	169	1	0	0	0	0	0	1	0	0	10034	876	31	1	73	1	MUC7	4	71346528	Nonsense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	61562729	71346528	119807748	34	31764											
BTF3	689	broad.mit.edu	37	chr5	72798376	72798376	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcagatgacaaaaaacttCagttctccttaaagaagtta	17	10	6	8	0	2	3	1	1	1	2	3	3	2	3	1	0	2	3	1	0	7	4			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr5:72798376C>G	uc003kcr.1	+	3	508	c.265C>G	c.(265-267)CAG>GAG	p.Q89E	BTF3_uc003kcq.1_Missense_Mutation_p.Q45E|BTF3_uc003kcs.1_RNA|BTF3_uc003kct.1_RNA	NM_001037637	NP_001032726	P20290	BTF3_HUMAN	basic transcription factor 3 isoform A	89	NAC-A/B.			Missing (in Ref. 2; AAA58398).	regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding				0		Lung NSC(167;0.00405)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;2.73e-54)		CAAAAAACTTCAGTTCTCCTT	0.383													6	35					0	0	0	0	G	72798376	G	G	72798376	3	3	169	1	0	0	0	0	1	0	0	0	1556	827	29	2	275	2	BTF3	5	72798376	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08		72798376	108116884	35	31765											
FAM172A	83989	broad.mit.edu	37	chr5	93300198	93300198	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttcaaattacaatccttttCcaggagctcatatacatact	13	15	3	10	0	2	0	2	0	0	0	4	1	4	1	2	1	4	1	2	1	6	7			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr5:93300198C>G	uc010jbd.2	-	5	547	c.340G>C	c.(340-342)GAA>CAA	p.E114Q	FAM172A_uc011cuf.1_Missense_Mutation_p.E68Q|FAM172A_uc011cug.1_Missense_Mutation_p.E68Q|FAM172A_uc011cuh.1_Missense_Mutation_p.E31Q|FAM172A_uc011cui.1_RNA|FAM172A_uc011cuj.1_Intron|FAM172A_uc003kkm.3_Missense_Mutation_p.E114Q	NM_032042	NP_114431	Q8WUF8	F172A_HUMAN	hypothetical protein LOC83989 isoform 1	114						endoplasmic reticulum|extracellular region					0						CAATCCTTTTCCAGGAGCTCA	0.264													3	19					0	0	0	0	G	93300198	G	G	93300198	3	3	169	1	0	0	0	0	1	0	0	0	5520	864	30	2	938	2	FAM172A	5	93300198	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	20501822	93300198	87615062	36	31766											
KCNN2	3781	broad.mit.edu	37	chr5	113798815	113798815	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgatatcaataacttttctCtccattggttatggtgacat	10	18	6	7	0	2	2	1	2	1	0	4	2	3	2	1	2	1	1	1	2	4	7			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr5:113798815C>G	uc003kqo.2	+	4	1528	c.1071C>G	c.(1069-1071)CTC>CTG	p.L357L	KCNN2_uc003kqp.2_Silent_p.L9L|KCNN2_uc010jcg.2_RNA|uc003kqq.1_Intron	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	357						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TAACTTTTCTCTCCATTGGTT	0.383													30	247					0	0	0	0	G	113798815	G	G	113798815	2	3	169	1	0	0	0	0	0	0	0	1	8118	900	32	2		2	KCNN2	5	113798815	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	20498617	113798815	67116445	37	31767											
MICB	4277	broad.mit.edu	37	chr6	31477569	31477569	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcttctccagagcttgtgagCctgcaggtcctggatcaaca	8	11	10	12	0	3	2	1	1	2	1	5	3	4	3	3	2	4	2	3	2	1	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:31477569C>T	uc003ntn.3	+	6	1151	c.1035C>T	c.(1033-1035)AGC>AGT	p.S345S	MICB_uc011dnm.1_Silent_p.S313S|MICB_uc003nto.3_Silent_p.S302S	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	345	Cytoplasmic (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						AGCTTGTGAGCCTGCAGGTCC	0.522													32	166					0	0	0	0	T	31477569	T	T	31477569	2	4	169	1	0	0	0	0	0	0	0	1	9628	738	26	4		4	MICB	6	31477569	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08		31477569	139637498	38	31768											
ZFAND3	60685	broad.mit.edu	37	chr6	38084398	38084398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaacggccacgactacttGagaatacggaacggtccgag	14	6	11	10	5	0	1	0	1	0	1	1	5	1	2	2	3	4	0	2	3	6	4			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:38084398G>A	uc003onx.2	+	5	827	c.412G>A	c.(412-414)GAG>AAG	p.E138K		NM_021943	NP_068762	Q9H8U3	ZFAN3_HUMAN	zinc finger, AN1-type domain 3	138							DNA binding|zinc ion binding			ovary(1)	1						ACGACTACTTGAGAATACGGA	0.498													18	116					0	0	0	0	A	38084398	A	A	38084398	3	1	169	1	0	0	0	0	1	0	0	0	17696	1291	45	2	430	2	ZFAND3	6	38084398	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	6606829	38084398	133030669	39	31769											
DEFB113	245927	broad.mit.edu	37	chr6	49937338	49937338	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaaatacaaagtatcttcaTtgctgatgcagttacacttg	15	13	6	7	0	2	1	1	1	1	0	2	1	2	1	0	0	4	4	0	0	6	6			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:49937338T>C	uc011dwq.1	-	1	1	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_001037729	NP_001032818	Q30KQ7	DB113_HUMAN	beta-defensin 113 precursor	1					defense response to bacterium	extracellular region					0	Lung NSC(77;0.042)					AGTATCTTCATTGCTGATGCA	0.343													16	89					0	0	0	0	C	49937338	C	C	49937338	3	2	169	1	0	0	0	0	1	0	0	0	4423	1507	52	5	247	5	DEFB113	6	49937338	Missense_Mutation	SNP	T	TCGA-CV-5431-01A-01D-1512-08	11852940	49937338	121177729	40	31770											
KLHL31	401265	broad.mit.edu	37	chr6	53519101	53519101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctcagtaaggcctgggcGtcccccaacagtgacgagga	9	7	12	13	2	1	1	1	1	1	0	3	3	2	2	3	3	1	1	3	3	2	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:53519101G>A	uc003pcb.3	-	2	1111	c.970C>T	c.(970-972)CGC>TGC	p.R324C		NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	324	Kelch 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					AGGCCTGGGCGTCCCCCAACA	0.478													54	116					0	0	0	0	A	53519101	A	A	53519101	3	1	169	1	0	0	0	0	1	0	0	0	8424	1145	40	1	942	1	KLHL31	6	53519101	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	3581763	53519101	117595966	41	31771											
DST	667	broad.mit.edu	37	chr6	56426989	56426989	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgttccttcaccatttaatActgctccacctgcaaaaata	12	13	3	13	0	1	0	1	0	0	0	3	0	3	0	4	0	3	3	4	0	5	6			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:56426989A>G	uc003pdf.2	-	50	7686	c.7658T>C	c.(7657-7659)GTA>GCA	p.V2553A	DST_uc003pcz.3_Missense_Mutation_p.V2375A|DST_uc011dxj.1_Missense_Mutation_p.V2404A|DST_uc011dxk.1_Missense_Mutation_p.V2415A|DST_uc003pcy.3_Missense_Mutation_p.V2049A	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4461					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACCATTTAATACTGCTCCACC	0.303													2	5					0	0	0	0	G	56426989	G	G	56426989	3	3	169	1	0	0	0	0	1	0	0	0	4805	391	14	5	9561	5	DST	6	56426989	Missense_Mutation	SNP	A	TCGA-CV-5431-01A-01D-1512-08	2907888	56426989	114688078	42	31772											
EYS	346007	broad.mit.edu	37	chr6	66115152	66115152	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcaccattttggctggaaGatccttttgggcattcataa	9	16	8	8	0	2	1	2	0	0	1	3	2	3	2	2	3	0	2	2	3	2	7			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:66115152G>A	uc011dxu.1	-	6	1509	c.971C>T	c.(970-972)TCT>TTT	p.S324F	EYS_uc003peq.2_Missense_Mutation_p.S324F|EYS_uc003per.1_Missense_Mutation_p.S324F	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	324					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TTGGCTGGAAGATCCTTTTGG	0.378													52	195					0	0	0	0	A	66115152	A	A	66115152	3	1	169	1	0	0	0	0	1	0	0	0	5357	942	33	2	8577	2	EYS	6	66115152	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	9688163	66115152	104999915	43	31773											
OSTM1	28962	broad.mit.edu	37	chr6	108395463	108395463	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtacccacccccgcggcTcggctgatgttgtccatctt	4	11	9	17	3	1	1	0	1	1	0	3	1	2	1	5	2	1	4	5	2	1	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:108395463T>A	uc003psd.2	-	1	479	c.393A>T	c.(391-393)CGA>CGT	p.R131R		NM_014028	NP_054747	Q86WC4	OSTM1_HUMAN	osteopetrosis associated transmembrane protein 1	131	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0131)|Epithelial(106;0.0438)|OV - Ovarian serous cystadenocarcinoma(136;0.0571)|all cancers(137;0.0581)		CCCCCGCGGCTCGGCTGATGT	0.597													8	23					0	0	0	0	A	108395463	A	A	108395463	2	1	169	1	0	0	0	0	0	0	0	1	11352	1538	54	5		5	OSTM1	6	108395463	Silent	SNP	T	TCGA-CV-5431-01A-01D-1512-08	42280311	108395463	62719604	44	31774											
MICAL1	64780	broad.mit.edu	37	chr6	109774946	109774946	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggtggagcacgttgtggcGagagaacttggtgcgctttt	7	11	17	6	3	0	1	0	0	0	1	0	5	0	2	0	4	3	3	0	4	1	4			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:109774946G>A	uc003ptj.2	-	2	615	c.361C>T	c.(361-363)CGC>TGC	p.R121C	MICAL1_uc003ptk.2_Missense_Mutation_p.R121C|MICAL1_uc010kdr.2_Missense_Mutation_p.R121C|MICAL1_uc011eaq.1_Missense_Mutation_p.R140C	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	121					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		ACGTTGTGGCGAGAGAACTTG	0.662													10	51					0	0	0	0	A	109774946	A	A	109774946	3	1	169	1	0	0	0	0	1	0	0	0	9622	1058	37	1	2934	1	MICAL1	6	109774946	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	1379483	109774946	61340121	45	31775											
LAMA2	3908	broad.mit.edu	37	chr6	129468119	129468119	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtattactactcggtcAaggatatttcagttggaggg	10	13	12	6	1	2	0	2	0	0	0	3	2	2	2	0	4	3	3	0	4	5	6			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:129468119A>G	uc003qbn.2	+	6	940	c.835A>G	c.(835-837)AAG>GAG	p.K279E	LAMA2_uc003qbo.2_Missense_Mutation_p.K279E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	279	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTACTCGGTCAAGGATATTTC	0.403													31	227					0	0	0	0	G	129468119	G	G	129468119	3	3	169	1	0	0	0	0	1	0	0	0	8646	131	5	5	857	5	LAMA2	6	129468119	Missense_Mutation	SNP	A	TCGA-CV-5431-01A-01D-1512-08	19693173	129468119	41646948	46	31776											
LAMA2	3908	broad.mit.edu	37	chr6	129774131	129774131	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgtatcttgttttttttaaAgatcaaagtatctgtgtctt	9	22	6	4	0	4	1	1	0	3	1	4	1	4	1	0	0	0	3	0	0	5	9			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:129774131A>C	uc003qbn.2	+	45	6535	c.6430_splice	c.e45-2	p.I2144_splice	LAMA2_uc003qbo.2_Splice_Site_p.I2144_splice	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor						cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTTTTTTTAAAGATCAAAGTA	0.343													13	65					0	0	0	0	C	129774131	C	C	129774131	5	2	169	1	0	0	0	0	0	0	1	0	8646	86	3	5	6610	5	LAMA2	6	129774131	Splice_Site	SNP	A	TCGA-CV-5431-01A-01D-1512-08	306012	129774131	41340936	47	31777											
RAB32	10981	broad.mit.edu	37	chr6	146865133	146865133	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgggcaagaccagcatcatCaagcgctacgtccaccagct	11	6	10	14	2	2	1	2	0	0	1	3	1	3	1	3	1	4	4	3	1	3	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr6:146865133C>G	uc003qln.1	+	1	306	c.126C>G	c.(124-126)ATC>ATG	p.I42M		NM_006834	NP_006825	Q13637	RAB32_HUMAN	RAB32, member RAS oncogene family	42					protein transport|small GTPase mediated signal transduction	mitochondrion	GTP binding				0		Ovarian(120;0.142)		OV - Ovarian serous cystadenocarcinoma(155;2.68e-09)|GBM - Glioblastoma multiforme(68;0.00608)		CCAGCATCATCAAGCGCTACG	0.522													13	36					0	0	0	0	G	146865133	G	G	146865133	3	3	169	1	0	0	0	0	1	0	0	0	12986	816	29	2	128	2	RAB32	6	146865133	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	17091002	146865133	24249934	48	31778											
DGKB	1607	broad.mit.edu	37	chr7	14622703	14622703	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatccaaaacccagcccacgGttccatctccaccacaggct	12	6	5	18	1	1	0	0	0	1	0	4	0	3	0	6	2	2	2	6	2	3	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr7:14622703G>A	uc003ssz.2	-	17	1683	c.1496C>T	c.(1495-1497)ACC>ATC	p.T499I	DGKB_uc011jxt.1_Missense_Mutation_p.T480I|DGKB_uc003sta.2_Missense_Mutation_p.T499I|DGKB_uc011jxu.1_Missense_Mutation_p.T498I	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	499	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	CCAGCCCACGGTTCCATCTCC	0.398													8	55					0	0	0	0	A	14622703	A	A	14622703	3	1	169	1	0	0	0	0	1	0	0	0	4488	1261	44	4	969	4	DGKB	7	14622703	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08		14622703	144515960	49	31779											
BAZ1B	9031	broad.mit.edu	37	chr7	72865288	72865288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagaaagtctgagcttcccGgattgctgtcttccatttct	7	14	10	10	1	3	2	0	1	3	1	5	4	5	3	2	2	2	2	2	2	1	4			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr7:72865288G>A	uc003tyc.2	-	14	3814	c.3469C>T	c.(3469-3471)CGG>TGG	p.R1157W		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	1157					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				TGAGCTTCCCGGATTGCTGTC	0.488													31	114					0	0	0	0	A	72865288	A	A	72865288	3	1	169	1	0	0	0	0	1	0	0	0	1332	1115	39	1	1006	1	BAZ1B	7	72865288	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	58242585	72865288	86273375	50	31780											
SEMA3E	9723	broad.mit.edu	37	chr7	83014715	83014715	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgttgttctctatgccataAgccagatgttcttcagtctt	7	17	7	10	0	4	1	1	0	3	1	5	1	4	1	2	0	2	3	2	0	2	7			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr7:83014715A>T	uc003uhy.1	-	16	2236	c.1770T>A	c.(1768-1770)GCT>GCA	p.A590A		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	590	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				CTATGCCATAAGCCAGATGTT	0.373													29	281					0	0	0	0	T	83014715	T	T	83014715	2	4	169	1	0	0	0	0	0	0	0	1	14093	59	3	5		5	SEMA3E	7	83014715	Silent	SNP	A	TCGA-CV-5431-01A-01D-1512-08	10149427	83014715	76123948	51	31781											
PARP12	64761	broad.mit.edu	37	chr7	139741627	139741627	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaaggtactggctgactcAgagcacaggatcctacagaa	14	7	11	9	0	1	4	1	2	0	2	2	5	2	5	1	3	3	3	1	3	4	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr7:139741627A>G	uc003vvl.1	-	6	1873	c.999T>C	c.(997-999)TCT>TCC	p.S333S	PARP12_uc003vvk.1_Silent_p.S119S|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	333	WWE 1.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					TGGCTGACTCAGAGCACAGGA	0.527													56	111					0	0	0	0	G	139741627	G	G	139741627	2	3	169	1	0	0	0	0	0	0	0	1	11511	175	7	5		5	PARP12	7	139741627	Silent	SNP	A	TCGA-CV-5431-01A-01D-1512-08	56726912	139741627	19397036	52	31782											
CSMD3	114788	broad.mit.edu	37	chr8	113812428	113812428	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaccaacagatccaacactTtcgtccgtttgaaggtgcag	13	9	8	11	2	0	2	0	1	0	1	3	2	2	2	3	1	4	2	3	1	4	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr8:113812428T>A	uc003ynu.2	-	13	2094	c.1935A>T	c.(1933-1935)GAA>GAT	p.E645D	CSMD3_uc003ynt.2_Missense_Mutation_p.E605D|CSMD3_uc011lhx.1_Missense_Mutation_p.E541D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	645	Extracellular (Potential).|CUB 3.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATCCAACACTTTCGTCCGTTT	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			37	90					0	0	0	0	A	113812428	A	A	113812428	3	1	169	1	0	0	0	0	1	0	0	0	3963	1838	64	5	9424	5	CSMD3	8	113812428	Missense_Mutation	SNP	T	TCGA-CV-5431-01A-01D-1512-08		113812428	32551594	53	31783											
KCNV2	169522	broad.mit.edu	37	chr9	2717793	2717793	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctacaggccctggaacacGacggagaatgagggcagcca	13	3	14	11	2	0	2	0	1	0	1	0	5	0	3	2	4	4	2	2	4	3	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr9:2717793G>A	uc003zho.1	+	1	268	c.54G>A	c.(52-54)ACG>ACA	p.T18T		NM_133497	NP_598004	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	18	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(50;0.0257)		CCTGGAACACGACGGAGAATG	0.607													74	158					0	0	0	0	A	2717793	A	A	2717793	2	1	169	1	0	0	0	0	0	0	0	1	8134	1045	37	1		1	KCNV2	9	2717793	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08		2717793	138495638	54	31784											
ORM1	5004	broad.mit.edu	37	chr9	117087155	117087155	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgacgtgaacgatgagaaGaactgggggctgtctgtcta	10	11	14	6	2	2	4	0	3	2	2	2	6	2	4	0	2	2	1	0	2	4	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr9:117087155G>C	uc004bik.3	+	4	525	c.414G>C	c.(412-414)AAG>AAC	p.K138N	ORM1_uc011lxo.1_Missense_Mutation_p.K138N	NM_000607	NP_000598	P02763	A1AG1_HUMAN	orosomucoid 1 precursor	138					acute-phase response|regulation of immune system process|transport	extracellular space	protein binding				0		Myeloproliferative disorder(63;0.163)			Acenocoumarol(DB01418)|Alfentanil(DB00802)|Aprindine(DB01429)|Disopyramide(DB00280)|Penbutolol(DB01359)|Phenprocoumon(DB00946)|Quinidine(DB00908)|Tamsulosin(DB00706)	ACGATGAGAAGAACTGGGGGC	0.567													10	73					0	0	0	0	C	117087155	C	C	117087155	3	2	169	1	0	0	0	0	1	0	0	0	11321	933	33	2	428	2	ORM1	9	117087155	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	114369362	117087155	24126276	55	31785											
TLR4	7099	broad.mit.edu	37	chr9	120470945	120470945	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacctgagctttaatcccctGaggcatttaggcagctatag	10	11	10	10	0	0	2	0	2	0	0	1	3	1	2	3	2	2	4	3	2	4	6			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr9:120470945G>A	uc004bjz.2	+	2	489	c.198G>A	c.(196-198)CTG>CTA	p.L66L	TLR4_uc004bka.2_Silent_p.L26L|TLR4_uc004bkb.2_Intron	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	66	LRR 1.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTAATCCCCTGAGGCATTTAG	0.438													29	212					0	0	0	0	A	120470945	A	A	120470945	2	1	169	1	0	0	0	0	0	0	0	1	16019	1277	45	2		2	TLR4	9	120470945	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08	3383790	120470945	20742486	56	31786											
PHF19	26147	broad.mit.edu	37	chr9	123629194	123629194	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggcactgggtgcaggcctCgtggaaccactgcctgcacc	7	6	14	14	1	0	0	0	0	0	0	1	2	0	1	4	4	4	3	4	4	1	0			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr9:123629194C>T	uc004bks.1	-	7	917	c.664G>A	c.(664-666)GAG>AAG	p.E222K	PHF19_uc011lyf.1_Missense_Mutation_p.E13K|PHF19_uc004bkr.2_RNA	NM_015651	NP_056466	Q5T6S3	PHF19_HUMAN	PHD finger protein 19 isoform a	222	PHD-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|breast(1)	2						GTGCAGGCCTCGTGGAACCAC	0.607													18	92					0	0	0	0	T	123629194	T	T	123629194	3	4	169	1	0	0	0	0	1	0	0	0	11884	893	31	1	1114	1	PHF19	9	123629194	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	3158249	123629194	17584237	57	31787											
GOLGA1	2800	broad.mit.edu	37	chr9	127685430	127685430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccctctaattcatccatttCatctctcctttggaaaagat	10	15	3	13	0	4	1	2	0	2	1	7	2	6	2	4	1	0	0	4	1	3	4			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr9:127685430C>T	uc004bpc.2	-	8	847	c.505G>A	c.(505-507)GAA>AAA	p.E169K	GOLGA1_uc010mws.2_RNA|GOLGA1_uc010mwt.1_Missense_Mutation_p.E144K	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	169	Potential.					Golgi cisterna membrane				ovary(1)	1						TCATCCATTTCATCTCTCCTT	0.348													34	182					0	0	0	0	T	127685430	T	T	127685430	3	4	169	1	0	0	0	0	1	0	0	0	6588	835	29	2	1862	2	GOLGA1	9	127685430	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	4056236	127685430	13528001	58	31788											
DOLK	22845	broad.mit.edu	37	chr9	131708357	131708357	+	Frame_Shift_Del	DEL	A	-	-																															acatgcccaggagcaggtagAtgtgtgtcagaatgagtggt																										TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr9:131708357delA	uc004bwr.2	-	1	1656	c.1226delT	c.(1225-1227)ATCfs	p.I409fs	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	dolichol kinase	409	Helical; (Potential).				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity				0						GAGCAGGTAGATGTGTGTCAG	0.577													---	---	---								-	131708357	-	-	131708357	7	5	169	1	0	1	0	1	0	0	0	0	4725	333	12	0	394	0	DOLK	9	131708357	Frame_Shift_Del	DEL	A	TCGA-CV-5431-01A-01D-1512-08	4022927	131708357	9505074	59	31789											
SNAPC4	6621	broad.mit.edu	37	chr9	139272877	139272877	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttcatattggctgggggctgCcaagagctgctcaacgctgg	7	10	14	10	1	2	1	2	0	0	1	2	1	2	1	1	4	4	5	1	4	3	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr9:139272877C>A	uc004chh.2	-	21	3411	c.3402G>T	c.(3400-3402)TGG>TGT	p.W1134C		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	1134	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CTGGGGGCTGCCAAGAGCTGC	0.687													5	17					5.9392e-07	6.09688e-07	1	0	A	139272877	A	A	139272877	3	1	169	1	0	0	0	0	1	0	0	0	14901	740	26	4	1015	4	SNAPC4	9	139272877	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	7564520	139272877	1940554	60	31790											
TUBB8	347688	broad.mit.edu	37	chr10	94647	94647	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagatccacgagcacagcgCggggcacgtacctgccacct	9	4	11	17	4	0	1	0	0	0	1	1	2	1	1	5	2	4	3	5	2	1	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr10:94647C>T	uc001ifi.2	-	3	185	c.185G>A	c.(184-186)CGC>CAC	p.R62H	TUBB8_uc009xhe.2_Intron|TUBB8_uc010pzs.1_5'UTR	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	62					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GAGCACAGCGCGGGGCACGTA	0.697													14	53					0	0	0	0	T	94647	T	T	94647	3	4	169	1	0	0	0	0	1	0	0	0	16829	768	27	1	1157	1	TUBB8	10	94647	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08		94647	135440100	61	31791											
LRRC4C	57689	broad.mit.edu	37	chr11	40137559	40137559	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtgtctcaagtgcttgaagCtgttcactttgatgatctgg	8	15	11	7	0	3	3	2	3	2	0	4	3	3	3	0	1	2	3	0	1	2	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr11:40137559C>A	uc001mxa.1	-	2	2248	c.284G>T	c.(283-285)AGC>ATC	p.S95I	LRRC4C_uc001mxc.1_Missense_Mutation_p.S91I|LRRC4C_uc001mxd.1_Missense_Mutation_p.S91I|LRRC4C_uc001mxb.1_Missense_Mutation_p.S91I	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	95	LRR 1.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTGCTTGAAGCTGTTCACTTT	0.473													32	90					7.72975e-29	8.37992e-29	1	0	A	40137559	A	A	40137559	3	1	169	1	0	0	0	0	1	0	0	0	9058	797	28	4	1642	4	LRRC4C	11	40137559	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08		40137559	94868957	62	31792											
OR5T3	390154	broad.mit.edu	37	chr11	56020434	56020434	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgtgatttcattctgttGtccattctgaagatgcattc	7	18	7	9	0	3	3	1	2	2	1	6	3	5	3	2	0	1	2	2	0	1	5			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr11:56020434G>T	uc010rjd.1	+	1	759	c.759G>T	c.(757-759)TTG>TTT	p.L253F		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	253	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TCATTCTGTTGTCCATTCTGA	0.423													58	380					6.176e-18	6.51287e-18	1	0	T	56020434	T	T	56020434	3	4	169	1	0	0	0	0	1	0	0	0	11237	1368	48	4	761	4	OR5T3	11	56020434	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	15882875	56020434	78986082	63	31793											
MAP3K11	4296	broad.mit.edu	37	chr11	65380600	65380600	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccagcacatggggaggcaCgcgccgcccggccagagctc	8	2	15	16	4	0	1	0	0	0	1	1	3	0	2	4	4	2	3	4	4	0	0			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr11:65380600C>T	uc001oew.2	-	1	1121	c.628G>A	c.(628-630)GTG>ATG	p.V210M	MAP3K11_uc010rol.1_5'Flank	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	210	Protein kinase.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity	p.V210M(1)		breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6						TGGGGAGGCACGCGCCGCCCG	0.657													14	72					0	0	0	0	T	65380600	T	T	65380600	3	4	169	1	0	0	0	0	1	0	0	0	9298	536	19	1	1955	1	MAP3K11	11	65380600	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	9360166	65380600	69625916	64	31794											
ROBO3	64221	broad.mit.edu	37	chr11	124743756	124743756	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttatgtgatagaggccttCaggtatggagaaagttttga	11	14	12	4	0	2	4	1	2	1	2	2	5	2	4	1	3	0	2	1	3	4	6			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr11:124743756C>T	uc001qbc.2	+	11	1974	c.1782C>T	c.(1780-1782)TTC>TTT	p.F594F	ROBO3_uc010saq.1_5'Flank|ROBO3_uc001qbd.2_5'Flank|ROBO3_uc010sar.1_5'Flank|ROBO3_uc001qbe.2_5'Flank	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	594	Fibronectin type-III 1.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TAGAGGCCTTCAGGTATGGAG	0.498													15	14					0	0	0	0	T	124743756	T	T	124743756	2	4	169	1	0	0	0	0	0	0	0	1	13580	825	29	2		2	ROBO3	11	124743756	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	59363156	124743756	10262760	65	31795											
DDX47	51202	broad.mit.edu	37	chr12	12966313	12966313	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacacaagatggcggcaccCgaggaacacgattctccgac	12	5	10	14	4	2	1	1	0	1	1	3	5	2	2	2	3	1	1	2	3	2	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr12:12966313C>T	uc001rav.2	+	4	610	c.12C>T	c.(10-12)CCC>CCT	p.P4P	DDX47_uc009zhw.1_Silent_p.P4P|DDX47_uc001rax.2_Silent_p.P4P|DDX47_uc001ray.2_Silent_p.P4P|DDX47_uc010shn.1_Silent_p.P4P	NM_016355	NP_057439	Q9H0S4	DDX47_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	4						nucleolus|nucleolus	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding				0		Prostate(47;0.0526)		BRCA - Breast invasive adenocarcinoma(232;0.0354)		TGGCGGCACCCGAGGAACACG	0.567											OREG0021680	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	42					0	0	0	0	T	12966313	T	T	12966313	2	4	169	1	0	0	0	0	0	0	0	1	4382	639	23	1		1	DDX47	12	12966313	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08		12966313	120885582	66	31796											
EMP1	2012	broad.mit.edu	37	chr12	13364446	13364446	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaaaaaaaagagccaacaTgttggtattgctggctggta	16	9	10	6	0	0	1	0	0	0	1	0	1	0	1	1	3	3	5	1	3	8	4			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr12:13364446T>A	uc001rbr.2	+	2	249	c.2T>A	c.(1-3)ATG>AAG	p.M1K	EMP1_uc009zhy.2_Intron|EMP1_uc010shr.1_Missense_Mutation_p.M1K	NM_001423	NP_001414	P54849	EMP1_HUMAN	epithelial membrane protein 1	1	Helical; (Potential).				cell growth|cell proliferation|epidermis development	integral to membrane|membrane fraction					0		Prostate(47;0.194)		BRCA - Breast invasive adenocarcinoma(232;0.153)		AGAGCCAACATGTTGGTATTG	0.373													158	164					0	0	0	0	A	13364446	A	A	13364446	3	1	169	1	0	0	0	0	1	0	0	0	5125	1464	51	5	4	5	EMP1	12	13364446	Missense_Mutation	SNP	T	TCGA-CV-5431-01A-01D-1512-08	398133	13364446	120487449	67	31797											
BICD1	636	broad.mit.edu	37	chr12	32260449	32260449	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggctgagtacgacagcCtcaaacaggagctggagcag	12	5	15	9	1	1	1	1	1	0	0	1	5	1	4	1	4	5	4	1	4	2	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr12:32260449C>T	uc001rku.2	+	1	265	c.184C>T	c.(184-186)CTC>TTC	p.L62F	BICD1_uc001rkv.2_Missense_Mutation_p.L62F|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	62	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			GTACGACAGCCTCAAACAGGA	0.587													9	9					0	0	0	0	T	32260449	T	T	32260449	3	4	169	1	0	0	0	0	1	0	0	0	1431	681	24	4	186	4	BICD1	12	32260449	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	18896003	32260449	101591446	68	31798											
DNM1L	10059	broad.mit.edu	37	chr12	32895604	32895604	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctagtaggccagctgtataaAtcatccttattggatgatct	11	14	8	8	0	2	1	1	1	1	0	3	2	3	2	2	2	1	3	2	2	6	6			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr12:32895604A>G	uc001rld.2	+	19	2237	c.2076A>G	c.(2074-2076)AAA>AAG	p.K692K	DNM1L_uc001rle.2_Silent_p.K666K|DNM1L_uc001rlf.2_Silent_p.K655K|DNM1L_uc010skh.1_Silent_p.K758K|DNM1L_uc001rlg.2_Silent_p.K747K|DNM1L_uc001rlh.2_Silent_p.K734K|DNM1L_uc010ski.1_Silent_p.K489K	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	692	GED.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AGCTGTATAAATCATCCTTAT	0.408													147	135					0	0	0	0	G	32895604	G	G	32895604	2	3	169	1	0	0	0	0	0	0	0	1	4693	98	4	5		5	DNM1L	12	32895604	Silent	SNP	A	TCGA-CV-5431-01A-01D-1512-08	635155	32895604	100956291	69	31799											
MYF5	4617	broad.mit.edu	37	chr12	81112691	81112691	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttggattgcttatccaacaTagtggaccggatcacctcct	9	12	8	12	1	1	0	1	0	0	0	3	3	3	3	4	3	2	1	4	3	3	4			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr12:81112691T>C	uc001szg.2	+	3	764	c.629T>C	c.(628-630)ATA>ACA	p.I210T		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	210					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						TTATCCAACATAGTGGACCGG	0.458													38	115					0	0	0	0	C	81112691	C	C	81112691	3	2	169	1	0	0	0	0	1	0	0	0	10080	1406	49	5	639	5	MYF5	12	81112691	Missense_Mutation	SNP	T	TCGA-CV-5431-01A-01D-1512-08	48217087	81112691	52739204	70	31800											
RHOF	54509	broad.mit.edu	37	chr12	122219075	122219075	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttctggtaggacaggggccGcagccggtcatagtcttctt	6	11	14	10	2	4	0	1	0	3	0	4	1	4	1	2	5	1	3	2	5	2	5			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr12:122219075G>A	uc001ubb.2	-	3	305	c.250C>T	c.(250-252)CGG>TGG	p.R84W	TMEM120B_uc001ubc.3_3'UTR|TMEM120B_uc009zxh.2_3'UTR|TMEM120B_uc001uba.1_Intron|RHOF_uc001ubd.3_Missense_Mutation_p.R84W	NM_019034	NP_061907	Q9HBH0	RHOF_HUMAN	ras homolog gene family, member F precursor	84					actin filament organization|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity			ovary(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;4.38e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.223)		GACAGGGGCCGCAGCCGGTCA	0.617													10	65					0	0	0	0	A	122219075	A	A	122219075	3	1	169	1	0	0	0	0	1	0	0	0	13403	1086	38	1	397	1	RHOF	12	122219075	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	41106384	122219075	11632820	71	31801											
WDR66	144406	broad.mit.edu	37	chr12	122413558	122413558	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagagcttccttttgtcatGagagcaattggcttttaccc	8	15	8	10	0	2	2	2	1	0	2	3	3	3	2	2	1	3	3	2	1	2	6			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr12:122413558G>A	uc009zxk.2	+	19	3115	c.2973G>A	c.(2971-2973)ATG>ATA	p.M991I		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	991							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CTTTTGTCATGAGAGCAATTG	0.443													15	102					0	0	0	0	A	122413558	A	A	122413558	3	1	169	1	0	0	0	0	1	0	0	0	17385	1290	45	2	3102	2	WDR66	12	122413558	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	194483	122413558	11438337	72	31802											
ATP8A2	51761	broad.mit.edu	37	chr13	26273327	26273327	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaggccacaagggcagccaTtactcagcactgcactgacc	11	6	9	15	0	2	1	2	1	0	0	2	1	2	1	3	2	4	3	3	2	2	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr13:26273327T>G	uc001uqk.2	+	25	2370	c.2228T>G	c.(2227-2229)ATT>AGT	p.I743S	ATP8A2_uc010tdi.1_Missense_Mutation_p.I703S|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.I293S	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	703	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGGGCAGCCATTACTCAGCAC	0.428													11	101					0	0	0	0	G	26273327	G	G	26273327	3	3	169	1	0	0	0	0	1	0	0	0	1195	1493	52	5	2326	5	ATP8A2	13	26273327	Missense_Mutation	SNP	T	TCGA-CV-5431-01A-01D-1512-08		26273327	88896551	73	31803											
PCDH20	64881	broad.mit.edu	37	chr13	61986457	61986457	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccagctgagtagaaactGtcagaattcctgtgacactg	11	10	11	9	0	1	4	1	2	0	2	3	4	3	4	2	1	2	2	2	1	3	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr13:61986457G>A	uc001vid.3	-	2	2139	c.1775C>T	c.(1774-1776)ACA>ATA	p.T592I	PCDH20_uc010thj.1_Missense_Mutation_p.T592I	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	565	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		AGTAGAAACTGTCAGAATTCC	0.473													22	213					0	0	0	0	A	61986457	A	A	61986457	3	1	169	1	0	0	0	0	1	0	0	0	11569	1377	48	4	1084	4	PCDH20	13	61986457	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	35713130	61986457	53183421	74	31804											
LMO7	4008	broad.mit.edu	37	chr13	76391321	76391321	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagtccatgagtgatgtcagCgcagaagatgttcaaaactt	14	10	10	7	1	2	4	2	2	0	2	3	4	3	4	1	0	2	2	1	0	4	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr13:76391321C>T	uc001vjv.2	+	9	2032	c.1272C>T	c.(1270-1272)AGC>AGT	p.S424S	LMO7_uc010thv.1_Silent_p.S375S|LMO7_uc001vjt.1_Silent_p.S323S|LMO7_uc010thw.1_Silent_p.S274S|LMO7_uc001vjw.1_Silent_p.S330S	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	709						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GTGATGTCAGCGCAGAAGATG	0.408													30	112					0	0	0	0	T	76391321	T	T	76391321	2	4	169	1	0	0	0	0	0	0	0	1	8897	767	27	1		1	LMO7	13	76391321	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	14404864	76391321	38778557	75	31805											
JUB	84962	broad.mit.edu	37	chr14	23451267	23451268	+	Frame_Shift_Ins	INS	-	G	G																															ctgatttcgctcagcgtccaINSgggaaccttgctcccgggcc																										TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr14:23451267_23451268insG	uc001whz.2	-	1	584_585	c.208_209insC	c.(208-210)CTGfs	p.L70fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	70	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CTCAGCGTCCAGGGAACCTTGC	0.693													---	---	---								G	23451268	G	G	23451267	7	5	169	1	0	1	1	0	0	0	0	0	8007	188	7	0	1439	0	JUB	14	23451267	Frame_Shift_Ins	INS	-	TCGA-CV-5431-01A-01D-1512-08		23451267	83898273	76	31806											
MDGA2	161357	broad.mit.edu	37	chr14	47426843	47426843	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atgctggttccactgcagggGgatctgtagaaaagatatgt	11	11	13	6	0	1	2	0	0	1	2	2	3	2	3	1	3	2	4	1	3	4	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr14:47426843G>C	uc001wwj.3	-	9	1812	c.1616C>G	c.(1615-1617)CCC>CGC	p.P539R	MDGA2_uc001wwi.3_Missense_Mutation_p.P310R|MDGA2_uc010ani.2_Missense_Mutation_p.P99R	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	539					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CACTGCAGGGGGATCTGTAGA	0.438													18	128					0	0	0	0	C	47426843	C	C	47426843	3	2	169	1	0	0	0	0	1	0	0	0	9460	1232	43	4	1290	4	MDGA2	14	47426843	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	23975576	47426843	59922697	77	31807											
TRIP11	9321	broad.mit.edu	37	chr14	92472287	92472287	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaactaacttttcatttTccattttgacatcaaaagca	15	15	2	9	0	2	1	2	1	0	0	3	1	3	1	1	0	3	1	1	0	5	8			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr14:92472287T>A	uc001xzy.2	-	11	2821	c.2033A>T	c.(2032-2034)GAA>GTA	p.E678V	TRIP11_uc010auf.1_Missense_Mutation_p.E414V	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	678	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CTTTTCATTTTCCATTTTGAC	0.318			T	PDGFRB	AML								21	128					0	0	0	0	A	92472287	A	A	92472287	3	1	169	1	0	0	0	0	1	0	0	0	16622	1783	62	5	3950	5	TRIP11	14	92472287	Missense_Mutation	SNP	T	TCGA-CV-5431-01A-01D-1512-08	45045444	92472287	14877253	78	31808											
KIAA0284	283638	broad.mit.edu	37	chr14	105359860	105359860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccggccctccctcttgcagCtggtgcagcgcatccccgag	4	7	12	18	3	1	0	0	0	1	0	3	1	3	0	5	2	4	4	5	2	0	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr14:105359860C>G	uc010axb.2	+	15	4263	c.4039C>G	c.(4039-4041)CTG>GTG	p.L1347V	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.L1277V|KIAA0284_uc001yps.2_Missense_Mutation_p.L1288V|KIAA0284_uc001ypt.2_Missense_Mutation_p.L15V	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	1382						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		CCTCTTGCAGCTGGTGCAGCG	0.672													2	1					0	0	0	0	G	105359860	G	G	105359860	3	3	169	1	0	0	0	0	1	0	0	0	8205	811	28	4	4093	4	KIAA0284	14	105359860	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	12887573	105359860	1989680	79	31809											
CRTC3	64784	broad.mit.edu	37	chr15	91181740	91181740	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagctcaagcccaggtgtcGccgccacccccttaccctgc	7	6	9	19	2	1	0	1	0	0	0	2	1	1	0	6	1	4	1	6	1	3	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr15:91181740G>A	uc002bpp.2	+	12	1435	c.1329G>A	c.(1327-1329)TCG>TCA	p.S443S	CRTC3_uc002bpo.2_Silent_p.S443S	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	443					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CCCAGGTGTCGCCGCCACCCC	0.632			T	MAML2	salivary gland mucoepidermoid								14	93					0	0	0	0	A	91181740	A	A	91181740	2	1	169	1	0	0	0	0	0	0	0	1	3916	1074	38	1		1	CRTC3	15	91181740	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08		91181740	11349652	80	31810											
CHD2	1106	broad.mit.edu	37	chr15	93510590	93510590	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agattttgaagaagaccatgGgaaggggagagaaaatggct	16	7	15	3	0	0	5	0	1	0	4	0	8	0	7	1	4	0	1	1	4	5	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr15:93510590G>T	uc002bsp.2	+	17	2611	c.2036G>T	c.(2035-2037)GGG>GTG	p.G679V	CHD2_uc002bso.1_Missense_Mutation_p.G679V	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	679					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GAAGACCATGGGAAGGGGAGA	0.398													11	72					1.49906e-05	1.52536e-05	1	0	T	93510590	T	T	93510590	3	4	169	1	0	0	0	0	1	0	0	0	3340	1232	43	4	2102	4	CHD2	15	93510590	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	2328850	93510590	9020802	81	31811											
LINS1	55180	broad.mit.edu	37	chr15	101120736	101120737	+	Frame_Shift_Ins	INS	-	AATA	AATA																															ggaactcggttttgacagacINSaatatccgggttgtcatcac																								rs61741890	byFrequency	TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr15:101120736_101120737insAATA	uc002bwe.2	-	3	602_603	c.311_312insTATT	c.(310-312)TTGfs	p.L104fs	LINS1_uc002bwf.2_Frame_Shift_Ins_p.L104fs|LINS1_uc002bwg.2_Frame_Shift_Ins_p.L104fs|LINS1_uc002bwh.2_Frame_Shift_Ins_p.L104fs|LINS1_uc010usa.1_Intron|LINS1_uc002bwi.2_Frame_Shift_Ins_p.L104fs	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	104											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			TTTTGACAGACAATATCCGGGT	0.406													---	---	---								AATA	101120737	AATA	AATA	101120736	7	5	169	1	0	1	1	0	0	0	0	0	8860	477	17	0	1985	0	LINS1	15	101120736	Frame_Shift_Ins	INS	-	TCGA-CV-5431-01A-01D-1512-08	7610146	101120736	1410656	82	31812											
PRSS36	146547	broad.mit.edu	37	chr16	31154165	31154165	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctcaggttcacgggcgtgCgcagctgcagcagcgccagg	6	5	16	14	5	2	0	2	0	0	0	2	0	2	0	1	3	5	6	1	3	0	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr16:31154165C>T	uc002ebd.2	-	9	1309	c.1250G>A	c.(1249-1251)CGC>CAC	p.R417H	PRSS36_uc010vff.1_Missense_Mutation_p.R192H|PRSS36_uc010vfg.1_Missense_Mutation_p.R417H|PRSS36_uc010vfh.1_Missense_Mutation_p.R417H	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	417	Peptidase S1 2.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						CACGGGCGTGCGCAGCTGCAG	0.751													6	18					0	0	0	0	T	31154165	T	T	31154165	3	4	169	1	0	0	0	0	1	0	0	0	12687	768	27	1	1345	1	PRSS36	16	31154165	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08		31154165	59200588	83	31813											
ADCY7	113	broad.mit.edu	37	chr16	50339755	50339755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcctggagaagggctttgagCgcgaggtgagggcccccagc	7	6	17	11	2	0	3	0	2	0	1	1	5	1	3	3	4	2	1	3	4	1	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr16:50339755C>T	uc002egd.1	+	13	2015	c.1747C>T	c.(1747-1749)CGC>TGC	p.R583C	ADCY7_uc002egc.1_Missense_Mutation_p.R583C	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	583	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	GGGCTTTGAGCGCGAGGTGAG	0.677													9	53					0	0	0	0	T	50339755	T	T	50339755	3	4	169	1	0	0	0	0	1	0	0	0	299	768	27	1	1797	1	ADCY7	16	50339755	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	19185590	50339755	40014998	84	31814											
DPEP3	64180	broad.mit.edu	37	chr16	68011603	68011603	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcaacaaattgtcacacaCagctctggcagctgagtggg	12	9	10	10	0	3	1	2	1	1	0	3	1	3	1	0	2	3	3	0	2	2	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr16:68011603C>T	uc002evc.3	-	6	1055	c.961G>A	c.(961-963)GTG>ATG	p.V321M	DPEP3_uc010cex.2_Missense_Mutation_p.V321M	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	296					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		TTGTCACACACAGCTCTGGCA	0.483													9	36					0	0	0	0	T	68011603	T	T	68011603	3	4	169	1	0	0	0	0	1	0	0	0	4737	478	17	4	600	4	DPEP3	16	68011603	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	17671848	68011603	22343150	85	31815											
PLCG2	5336	broad.mit.edu	37	chr16	81927341	81927341	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaggtgaccagctgcggagCgagtcgtccccagaagctta	10	6	13	12	3	0	2	0	1	0	1	2	4	1	3	3	2	4	2	3	2	2	1			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr16:81927341C>T	uc002fgt.2	+	12	1166	c.1014C>T	c.(1012-1014)AGC>AGT	p.S338S	PLCG2_uc010chg.1_Silent_p.S338S	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	338	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						AGCTGCGGAGCGAGTCGTCCC	0.617													11	78					0	0	0	0	T	81927341	T	T	81927341	2	4	169	1	0	0	0	0	0	0	0	1	12091	767	27	1		1	PLCG2	16	81927341	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	13915738	81927341	8427412	86	31816											
TP53	7157	broad.mit.edu	37	chr17	7578265	7578265	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaatttccttccactcggAtaagatgctgaggaggggcc	10	9	12	10	1	0	2	0	1	0	1	3	4	2	4	3	4	1	2	3	4	2	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr17:7578265A>G	uc002gim.2	-	6	778	c.584T>C	c.(583-585)ATC>ACC	p.I195T	TP53_uc002gig.1_Missense_Mutation_p.I195T|TP53_uc002gih.2_Missense_Mutation_p.I195T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.I63T|TP53_uc010cng.1_Missense_Mutation_p.I63T|TP53_uc002gii.1_Missense_Mutation_p.I63T|TP53_uc010cnh.1_Missense_Mutation_p.I195T|TP53_uc010cni.1_Missense_Mutation_p.I195T|TP53_uc002gij.2_Missense_Mutation_p.I195T|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.I102T|TP53_uc002gio.2_Missense_Mutation_p.I63T|TP53_uc010vug.1_Missense_Mutation_p.I156T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	195	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		I -> F (in sporadic cancers; somatic mutation).|I -> L (in a sporadic cancer; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> T (in sporadic cancers; somatic mutation).|I -> V (in a sporadic cancer; somatic mutation).|I -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|I -> N (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.I195T(61)|p.I195F(16)|p.I195N(12)|p.0?(7)|p.I195S(4)|p.A189_V197delAPPQHLIRV(4)|p.I195fs*14(3)|p.I195fs*52(3)|p.K164_P219del(1)|p.I195L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.I195fs*12(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCCACTCGGATAAGATGCTG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	50					0	0	0	0	G	7578265	G	G	7578265	3	3	169	1	0	0	0	0	1	0	0	0	16448	333	12	5	710	5	TP53	17	7578265	Missense_Mutation	SNP	A	TCGA-CV-5431-01A-01D-1512-08		7578265	73616945	87	31817											
ARSG	22901	broad.mit.edu	37	chr17	66366598	66366598	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctaggagacaatggcccGtgggctcagaagtgtgagct	9	10	14	8	1	2	3	1	1	1	2	2	4	2	3	1	3	1	2	1	3	3	2	rs149931351	by1000genomes	TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr17:66366598G>A	uc002jhc.2	+	8	1711	c.915G>A	c.(913-915)CCG>CCA	p.P305P	ARSG_uc002jhb.1_Silent_p.P141P	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	305					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			ACAATGGCCCGTGGGCTCAGA	0.552													10	61					0	0	0	0	A	66366598	A	A	66366598	2	1	169	1	0	0	0	0	0	0	0	1	994	1132	40	1		1	ARSG	17	66366598	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08	58788333	66366598	14828612	88	31818											
CASKIN2	57513	broad.mit.edu	37	chr17	73497569	73497569	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcttgctccttggtgccAatgctcttctctgcggctct	2	15	8	16	1	4	0	0	0	4	0	6	0	5	0	3	2	4	3	3	2	1	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr17:73497569A>C	uc002joc.2	-	19	4048	c.3498T>G	c.(3496-3498)ATT>ATG	p.I1166M	CASKIN2_uc010wsc.1_Missense_Mutation_p.I1084M	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	1166						cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCTTGGTGCCAATGCTCTTCT	0.647													24	146					0	0	0	0	C	73497569	C	C	73497569	3	2	169	1	0	0	0	0	1	0	0	0	2679	126	5	5	118	5	CASKIN2	17	73497569	Missense_Mutation	SNP	A	TCGA-CV-5431-01A-01D-1512-08	7130971	73497569	7697641	89	31819											
CEP192	55125	broad.mit.edu	37	chr18	13056573	13056573	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggatgggtacctcttccctCtgtaacccatattctaatac	9	14	6	12	0	3	0	0	0	3	0	4	1	4	1	3	2	3	2	3	2	5	7			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr18:13056573C>T	uc010xac.1	+	19	4064	c.3984C>T	c.(3982-3984)CTC>CTT	p.L1328L	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Silent_p.L853L|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Silent_p.L1069L	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1328										ovary(4)|pancreas(1)	5						CCTCTTCCCTCTGTAACCCAT	0.468													36	218					0	0	0	0	T	13056573	T	T	13056573	2	4	169	1	0	0	0	0	0	0	0	1	3266	900	32	2		2	CEP192	18	13056573	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08		13056573	65020675	90	31820											
POTEC	388468	broad.mit.edu	37	chr18	14542737	14542737	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagcttgtccagatcttctcGacggacgtggtacctcggct	6	11	12	12	4	2	1	0	0	2	1	5	4	3	2	2	3	2	3	2	3	1	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr18:14542737G>A	uc010dln.2	-	1	863	c.409C>T	c.(409-411)CGA>TGA	p.R137*	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	137										skin(3)	3						AGATCTTCTCGACGGACGTGG	0.602													28	159					0	0	0	0	A	14542737	A	A	14542737	4	1	169	1	0	0	0	0	0	1	0	0	12317	1066	37	1	1263	1	POTEC	18	14542737	Nonsense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	1486164	14542737	63534511	91	31821											
ZNF414	84330	broad.mit.edu	37	chr19	8577310	8577310	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagtgcagtttgctgtgaGccaccagctcctgcatgctg	6	12	12	11	0	0	1	0	1	0	0	1	1	1	1	3	0	6	7	3	0	1	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr19:8577310G>A	uc002mkf.2	-	4	609	c.491C>T	c.(490-492)GCT>GTT	p.A164V	ZNF414_uc002mke.3_Missense_Mutation_p.A164V|ZNF414_uc010dwf.2_Missense_Mutation_p.A153V	NM_032370	NP_115746	Q96IQ9	ZN414_HUMAN	zinc finger protein 414 isoform 2	164	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTTGCTGTGAGCCACCAGCTC	0.587													36	96					0	0	0	0	A	8577310	A	A	8577310	3	1	169	1	0	0	0	0	1	0	0	0	17958	971	34	4	715	4	ZNF414	19	8577310	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08		8577310	50551673	92	31822											
CCDC97	90324	broad.mit.edu	37	chr19	41825480	41825480	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgtctctcctctgtgcaggGggcgagtacttcagtgatga	6	12	13	10	1	3	2	1	2	2	0	5	3	4	2	1	2	2	2	1	2	1	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr19:41825480G>A	uc002oqg.2	+	3	626	c.504G>A	c.(502-504)GGG>GGA	p.G168G	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	168											0						TCTGTGCAGGGGGCGAGTACT	0.572													23	176					0	0	0	0	A	41825480	A	A	41825480	2	1	169	1	0	0	0	0	0	0	0	1	2888	1246	43	4		4	CCDC97	19	41825480	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08	33248170	41825480	17303503	93	31823											
TPRX1	284355	broad.mit.edu	37	chr19	48305393	48305393	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgagccagggcttcgcatcCggccaggacttaagatggga	9	7	15	10	2	0	2	0	1	0	1	2	4	1	4	3	4	1	2	3	4	1	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr19:48305393C>A	uc002php.1	-	2	946	c.875G>T	c.(874-876)CGG>CTG	p.R292L		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox	292	Gly-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		GCTTCGCATCCGGCCAGGACT	0.383													37	53					6.97489e-18	7.28907e-18	1	0	A	48305393	A	A	48305393	3	1	169	1	0	0	0	0	1	0	0	0	16489	652	23	3	364	3	TPRX1	19	48305393	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	6479913	48305393	10823590	94	31824											
PTPRT	11122	broad.mit.edu	37	chr20	40713412	40713412	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctttgagcagagagcgcttgGaggggggcgtgtcccggtag	6	8	19	8	3	0	2	0	1	0	1	1	4	1	3	1	5	2	3	1	5	1	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr20:40713412G>A	uc002xkg.2	-	29	4230	c.4046C>T	c.(4045-4047)TCC>TTC	p.S1349F	PTPRT_uc010ggj.2_Missense_Mutation_p.S1368F|PTPRT_uc010ggi.2_Missense_Mutation_p.S552F	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1349	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGAGCGCTTGGAGGGGGGCGT	0.587													11	37					0	0	0	0	A	40713412	A	A	40713412	3	1	169	1	0	0	0	0	1	0	0	0	12877	1174	41	2	291	2	PTPRT	20	40713412	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08		40713412	22312108	95	31825											
CEBPB	1051	broad.mit.edu	37	chr20	48807602	48807602	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggcctgggacccagcatGtctccccctgccgccgccgc	3	6	13	19	3	1	0	0	0	1	0	2	1	1	1	7	3	2	1	7	3	0	0			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr20:48807602G>C	uc002xvi.1	+	1	227	c.32G>C	c.(31-33)TGT>TCT	p.C11S	CEBPB_uc002xvh.2_RNA	NM_005194	NP_005185	P17676	CEBPB_HUMAN	CCAAT/enhancer binding protein beta	11	Required for Lys-174 sumoylation.				acute-phase response|immune response		sequence-specific enhancer binding RNA polymerase II transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(9;5.72e-08)|STAD - Stomach adenocarcinoma(23;0.19)			GACCCAGCATGTCTCCCCCTG	0.701													4	8					0	0	0	0	C	48807602	C	C	48807602	3	2	169	1	0	0	0	0	1	0	0	0	3215	1377	48	4	34	4	CEBPB	20	48807602	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08	8094190	48807602	14217918	96	31826											
CDH26	60437	broad.mit.edu	37	chr20	58587740	58587740	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gactctttgggttcaaaagcGactccgtttgaggaaatata	12	12	10	7	2	2	1	1	1	1	0	3	4	3	2	1	2	1	2	1	2	5	5	rs141182679		TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr20:58587740G>A	uc002ybe.2	+	18	2754	c.2454G>A	c.(2452-2454)GCG>GCA	p.A818A	CDH26_uc002ybf.1_Intron|CDH26_uc010zzy.1_RNA|CDH26_uc002ybg.2_Silent_p.A309A|CDH26_uc002ybh.2_Silent_p.A151A|CDH26_uc002ybi.2_Silent_p.A110A	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	Error:Variant_position_missing_in_Q8IXH8_after_alignment					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GTTCAAAAGCGACTCCGTTTG	0.458													36	110					0	0	0	0	A	58587740	A	A	58587740	2	1	169	1	0	0	0	0	0	0	0	1	3125	1045	37	1		1	CDH26	20	58587740	Silent	SNP	G	TCGA-CV-5431-01A-01D-1512-08	9780138	58587740	4437780	97	31827											
KRTAP10-10	353333	broad.mit.edu	37	chr21	46057890	46057890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaccgcctcctgctgcagaCcctcctcctccgtgtccctc	3	9	7	22	2	0	1	0	0	0	1	6	1	5	1	8	0	2	3	8	0	0	0			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr21:46057890C>T	uc002zfq.2	+	1	618	c.556C>T	c.(556-558)CCC>TCC	p.P186S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	186	15 X 5 AA repeats of C-C-X(3).|13.					keratin filament					0						CTGCTGCAGACCCTCCTCCTC	0.652													40	162					0	0	0	0	T	46057890	T	T	46057890	3	4	169	1	0	0	0	0	1	0	0	0	8545	507	18	4	558	4	KRTAP10-10	21	46057890	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08		46057890	2072005	98	31828											
UBE2L3	7332	broad.mit.edu	37	chr22	21975875	21975875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcgggctgacctagctgaaGaatactctaaggaccgtaaa	13	9	10	9	2	1	3	0	2	1	1	2	4	1	4	2	2	2	3	2	2	7	5			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr22:21975875G>A	uc002zva.1	+	4	459	c.382G>A	c.(382-384)GAA>AAA	p.E128K	UBE2L3_uc011aig.1_Missense_Mutation_p.E96K|UBE2L3_uc002zuz.1_3'UTR|UBE2L3_uc010gti.1_RNA	NM_003347	NP_003338	P68036	UB2L3_HUMAN	ubiquitin-conjugating enzyme E2L 3	128					cell proliferation|cellular response to glucocorticoid stimulus|protein K11-linked ubiquitination|regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	ATP binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0	Colorectal(54;0.105)					CCTAGCTGAAGAATACTCTAA	0.488													9	45					0	0	0	0	A	21975875	A	A	21975875	3	1	169	1	0	0	0	0	1	0	0	0	16931	943	33	2	396	2	UBE2L3	22	21975875	Missense_Mutation	SNP	G	TCGA-CV-5431-01A-01D-1512-08		21975875	29328691	99	31829											
EFCAB6	64800	broad.mit.edu	37	chr22	43985982	43985982	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagatgggtcagctccccttCggtaagagaacatccacatt	11	9	9	12	1	1	2	1	0	0	2	4	3	3	2	3	2	2	2	3	2	2	3			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chr22:43985982C>T	uc003bdy.1	-	24	3219	c.3004G>A	c.(3004-3006)GAA>AAA	p.E1002K	EFCAB6_uc003bdz.1_Missense_Mutation_p.E850K|EFCAB6_uc010gzi.1_Missense_Mutation_p.E850K|EFCAB6_uc010gzj.1_Missense_Mutation_p.E228K	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1002					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				AGCTCCCCTTCGGTAAGAGAA	0.408													84	99					0	0	0	0	T	43985982	T	T	43985982	3	4	169	1	0	0	0	0	1	0	0	0	4961	893	31	1	1537	1	EFCAB6	22	43985982	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	22010107	43985982	7318584	100	31830											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29938080	29938080	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttagaattcttaaggagcAtcttggggaacaggaagttt	12	14	11	4	0	2	1	0	0	2	1	2	4	2	4	0	4	2	2	0	4	5	6			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chrX:29938080A>G	uc004dby.2	+	8	1434	c.926A>G	c.(925-927)CAT>CGT	p.H309R		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	309	Extracellular (Potential).|Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						CTTAAGGAGCATCTTGGGGAA	0.363													42	107					0	0	0	0	G	29938080	G	G	29938080	3	3	169	1	0	0	0	0	1	0	0	0	7700	217	8	5	952	5	IL1RAPL1	23	29938080	Missense_Mutation	SNP	A	TCGA-CV-5431-01A-01D-1512-08		29938080	125332480	101	31831											
TEX11	56159	broad.mit.edu	37	chrX	69749731	69749731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtaaggtggttaaggaaaCgcaaggccaggccacaccac	14	4	13	10	1	0	0	0	0	0	0	0	1	0	1	3	6	1	3	3	6	4	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chrX:69749731C>T	uc004dyl.2	-	30	2846	c.2684G>A	c.(2683-2685)CGT>CAT	p.R895H	TEX11_uc004dyk.2_Missense_Mutation_p.R570H|TEX11_uc004dym.2_Missense_Mutation_p.R880H	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	895							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					GTTAAGGAAACGCAAGGCCAG	0.498													7	59					0	0	0	0	T	69749731	T	T	69749731	3	4	169	1	0	0	0	0	1	0	0	0	15840	536	19	1	146	1	TEX11	23	69749731	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	39811651	69749731	85520829	102	31832											
TCEAL5	340543	broad.mit.edu	37	chrX	102528984	102528984	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtacatctctttgcatccAatgaaaaccacccattttct	11	14	3	13	0	2	1	0	1	2	0	4	1	3	1	3	0	3	2	3	0	4	4			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chrX:102528984A>C	uc004ejz.1	-	3	803	c.508T>G	c.(508-510)TGG>GGG	p.W170G		NM_001012979	NP_001012997	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(1)|breast(1)	2						CTTTGCATCCAATGAAAACCA	0.512													43	106					0	0	0	0	C	102528984	C	C	102528984	3	2	169	1	0	0	0	0	1	0	0	0	15740	130	5	5	116	5	TCEAL5	23	102528984	Missense_Mutation	SNP	A	TCGA-CV-5431-01A-01D-1512-08	32779253	102528984	52741576	103	31833											
MID2	11043	broad.mit.edu	37	chrX	107170195	107170195	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggaacaaatccctaatgatCctgtctggcttgcctgcccc	8	11	8	14	0	1	1	0	1	1	0	3	2	3	2	5	2	3	1	5	2	3	2			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chrX:107170195C>A	uc004enl.2	+	10	2673	c.2100C>A	c.(2098-2100)ATC>ATA	p.I700I	MID2_uc004enk.2_Silent_p.I670I	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	700	B30.2/SPRY.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						CCCTAATGATCCTGTCTGGCT	0.443													36	94					9.73076e-26	1.04516e-25	1	0	A	107170195	A	A	107170195	2	1	169	1	0	0	0	0	0	0	0	1	9631	845	30	2		2	MID2	23	107170195	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	4641211	107170195	48100365	104	31834											
LUZP4	51213	broad.mit.edu	37	chrX	114536558	114536558	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgtattttctaatacagaCgacattataatctataaaga	17	15	4	5	1	2	2	0	0	2	2	2	3	2	2	0	0	1	1	0	0	9	10			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chrX:114536558C>T	uc004eqa.2	+	2	127	c.93C>T	c.(91-93)GAC>GAT	p.D31D	LUZP4_uc004eqb.2_Translation_Start_Site	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	31						nucleus		p.D31Y(1)		ovary(2)	2						CTAATACAGACGACATTATAA	0.299													17	36					0	0	0	0	T	114536558	T	T	114536558	2	4	169	1	0	0	0	0	0	0	0	1	9138	550	19	1		1	LUZP4	23	114536558	Silent	SNP	C	TCGA-CV-5431-01A-01D-1512-08	7366363	114536558	40734002	105	31835											
MAP7D3	79649	broad.mit.edu	37	chrX	135314215	135314215	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggggggtgcatccacacttgCcttgggaggtgtctctactt	5	12	14	10	0	1	0	0	0	1	0	3	1	2	1	2	5	3	1	2	5	1	4			TCGA-CV-5431-01A-01D-1512-08	TCGA-CV-5431-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f1a234f0-8890-4cf3-891f-c7a7423b1e75	9fd15bac-b77c-4246-b8d7-895e9cd0e4d3	g.chrX:135314215C>T	uc004ezt.2	-	8	992	c.901G>A	c.(901-903)GCA>ACA	p.A301T	MAP7D3_uc004ezs.2_Missense_Mutation_p.A265T|MAP7D3_uc011mwc.1_Missense_Mutation_p.A283T|MAP7D3_uc010nsa.1_Missense_Mutation_p.A259T	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	301						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					TCCACACTTGCCTTGGGAGGT	0.517													72	239					0	0	0	0	T	135314215	T	T	135314215	3	4	169	1	0	0	0	0	1	0	0	0	9322	739	26	4	1773	4	MAP7D3	23	135314215	Missense_Mutation	SNP	C	TCGA-CV-5431-01A-01D-1512-08	20777657	135314215	19956345	106	31836											
NOC2L	26155	broad.mit.edu	37	chr1	880925	880925	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgagaatccctcggtgtcgtCctcttcagagctgttcaggt	6	12	11	12	3	3	2	2	0	1	2	7	3	5	2	2	2	1	2	2	2	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:880925C>A	uc001abz.3	-	17	2085	c.2026G>T	c.(2026-2028)GAC>TAC	p.D676Y	NOC2L_uc001aby.3_Missense_Mutation_p.D473Y|NOC2L_uc009vjq.2_Missense_Mutation_p.D676Y	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	676	Asp/Glu-rich (acidic).					nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		TCGGTGTCGTCCTCTTCAGAG	0.577													42	18					4.01765e-15	5.3071e-15	1	0	A	880925	A	A	880925	3	1	170	1	0	0	0	0	1	0	0	0	10567	855	30	2	235	2	NOC2L	1	880925	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08		880925	248369696	1	31837											
MFN2	9927	broad.mit.edu	37	chr1	12064156	12064156	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgcgaattaagcagattaCggaggaagtggagaggcagg	13	6	17	5	2	0	2	0	0	0	2	0	6	0	4	0	5	3	3	0	5	4	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:12064156C>T	uc001atn.3	+	12	1721	c.1268C>T	c.(1267-1269)ACG>ATG	p.T423M	MFN2_uc009vni.2_Missense_Mutation_p.T423M	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	423	Cytoplasmic (Potential).|Potential.				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		AAGCAGATTACGGAGGAAGTG	0.493													16	19					0	0	0	0	T	12064156	T	T	12064156	3	4	170	1	0	0	0	0	1	0	0	0	9577	536	19	1	1306	1	MFN2	1	12064156	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	11183231	12064156	237186465	2	31838											
WDTC1	23038	broad.mit.edu	37	chr1	27627909	27627909	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcagcgcttgtgatgcattGggccgcgacatcacagctgc	8	8	13	12	3	1	1	1	1	0	0	1	2	1	1	1	1	5	4	1	1	0	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:27627909G>A	uc009vst.2	+	13	1960	c.1425G>A	c.(1423-1425)TTG>TTA	p.L475L	WDTC1_uc001bno.2_Silent_p.L474L|WDTC1_uc001bnp.1_RNA|WDTC1_uc001bnq.2_Silent_p.L153L	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	475							protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		GTGATGCATTGGGCCGCGACA	0.507													23	9					0	0	0	0	A	27627909	A	A	27627909	2	1	170	1	0	0	0	0	0	0	0	1	17410	1339	47	4		4	WDTC1	1	27627909	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	15563753	27627909	221622712	3	31839											
DEPDC1	55635	broad.mit.edu	37	chr1	68948183	68948183	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgaaagacactggatgcCtctttacttgaattccctgg	10	13	9	9	0	1	4	0	3	1	1	2	5	2	5	2	2	2	0	2	2	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:68948183C>T	uc001dem.3	-	8	1425	c.1308G>A	c.(1306-1308)GAG>GAA	p.E436E	DEPDC1_uc001dej.3_5'Flank|DEPDC1_uc001dek.3_Intron|DEPDC1_uc001del.3_Intron	NM_001114120	NP_001107592	Q5TB30	DEP1A_HUMAN	DEP domain containing 1 isoform a	436					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		CACTGGATGCCTCTTTACTTG	0.373													70	45					0	0	0	0	T	68948183	T	T	68948183	2	4	170	1	0	0	0	0	0	0	0	1	4461	680	24	4		4	DEPDC1	1	68948183	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	41320274	68948183	180302438	4	31840											
COL11A1	1301	broad.mit.edu	37	chr1	103491779	103491779	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctttgtttttacctccgtcTgtgctattgtctcctcagtt	3	20	7	11	1	3	0	1	0	2	0	5	0	4	0	3	0	2	4	3	0	2	7			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:103491779T>A	uc001dul.2	-	6	1208	c.890A>T	c.(889-891)CAG>CTG	p.Q297L	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Intron|COL11A1_uc001dun.2_Intron|COL11A1_uc009weh.2_Missense_Mutation_p.Q297L	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	297	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TACCTCCGTCTGTGCTATTGT	0.443													15	16					0	0	0	0	A	103491779	A	A	103491779	3	1	170	1	0	0	0	0	1	0	0	0	3682	1580	55	5	4935	5	COL11A1	1	103491779	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	34543596	103491779	145758842	5	31841											
PLEKHO1	51177	broad.mit.edu	37	chr1	150131633	150131633	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcagggagctgagagaccTgtacagacagatggacctgc	11	6	15	9	0	1	4	1	1	0	3	1	7	1	6	2	3	3	2	2	3	1	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:150131633T>A	uc001ett.2	+	6	1423	c.1145T>A	c.(1144-1146)CTG>CAG	p.L382Q	PLEKHO1_uc001etr.2_Missense_Mutation_p.L210Q|PLEKHO1_uc001ets.2_Missense_Mutation_p.L199Q|PLEKHO1_uc001etu.2_Missense_Mutation_p.L210Q	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	382	Negative regulator of AP-1 activity.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTGAGAGACCTGTACAGACAG	0.622													7	13					0	0	0	0	A	150131633	A	A	150131633	3	1	170	1	0	0	0	0	1	0	0	0	12139	1580	55	5	1167	5	PLEKHO1	1	150131633	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	46639854	150131633	99118988	6	31842											
HRNR	388697	broad.mit.edu	37	chr1	152191599	152191599	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctggctagagaagtgacCtgaggcagaaccatgctgac	11	7	12	11	0	0	5	0	3	0	2	1	6	1	5	3	2	2	3	3	2	3	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:152191599C>A	uc001ezt.1	-	3	2582	c.2506G>T	c.(2506-2508)GGT>TGT	p.G836C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	836	8.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGAAGTGACCTGAGGCAGAA	0.547													17	39					3.52763e-06	3.96352e-06	1	0	A	152191599	A	A	152191599	3	1	170	1	0	0	0	0	1	0	0	0	7398	681	24	4	6050	4	HRNR	1	152191599	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	2059966	152191599	97059022	7	31843											
FLG	2312	broad.mit.edu	37	chr1	152283555	152283555	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcactgtcctggctaacActggatccctggtgcctgct	5	12	10	14	0	1	0	1	0	0	0	3	1	3	1	3	3	3	2	3	3	1	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:152283555A>T	uc001ezu.1	-	3	3843	c.3807T>A	c.(3805-3807)AGT>AGA	p.S1269R	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1269	Ser-rich.|Filaggrin 7.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGGCTAACACTGGATCCCT	0.458									Ichthyosis				71	95					0	0	0	0	T	152283555	T	T	152283555	3	4	170	1	0	0	0	0	1	0	0	0	5954	156	6	5	8382	5	FLG	1	152283555	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	91956	152283555	96967066	8	31844											
IVL	3713	broad.mit.edu	37	chr1	152882594	152882594	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagaaaacccagagcagcaGcttaagcaggagaaaacaca	19	2	10	10	0	0	3	0	0	0	3	0	4	0	3	1	1	6	5	1	1	5	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:152882594G>A	uc001fau.2	+	2	367	c.321G>A	c.(319-321)CAG>CAA	p.Q107Q		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	107					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGAGCAGCAGCTTAAGCAGG	0.313													8	12					0	0	0	0	A	152882594	A	A	152882594	2	1	170	1	0	0	0	0	0	0	0	1	7968	962	34	4		4	IVL	1	152882594	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	599039	152882594	96368027	9	31845											
UBE2Q1	55585	broad.mit.edu	37	chr1	154528425	154528425	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccgaccagatggggggcaCagcagggtatgactcctgaa	11	5	14	11	1	0	3	0	2	0	1	1	4	1	3	3	4	1	3	3	4	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:154528425C>G	uc001fff.1	-	2	434	c.343G>C	c.(343-345)GTG>CTG	p.V115L		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	115							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			ATGGGGGGCACAGCAGGGTAT	0.527													15	37					0	0	0	0	G	154528425	G	G	154528425	3	3	170	1	0	0	0	0	1	0	0	0	16937	478	17	4	973	4	UBE2Q1	1	154528425	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	1645831	154528425	94722196	10	31846											
FCRL4	83417	broad.mit.edu	37	chr1	157556137	157556137	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcggtgccaggagaatgtgGtatcccctgtgccttcagcc	6	10	12	13	1	1	1	1	0	0	1	3	2	2	1	5	3	3	1	5	3	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:157556137G>C	uc001fqw.2	-	6	1092	c.956C>G	c.(955-957)ACC>AGC	p.T319S	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	319	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GGAGAATGTGGTATCCCCTGT	0.617													15	37					0	0	0	0	C	157556137	C	C	157556137	3	2	170	1	0	0	0	0	1	0	0	0	5829	1261	44	4	619	4	FCRL4	1	157556137	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	3027712	157556137	91694484	11	31847											
CD1E	913	broad.mit.edu	37	chr1	158324270	158324270	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagctgggcacacagtgaGggctcaggatggctgggtga	9	6	17	9	0	1	2	1	2	0	0	1	3	1	3	0	5	1	4	0	5	0	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:158324270G>C	uc001fse.2	+	2	401	c.162G>C	c.(160-162)GAG>GAC	p.E54D	CD1E_uc010pid.1_Missense_Mutation_p.E52D|CD1E_uc010pie.1_Intron|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.E54D|CD1E_uc001fsk.2_Missense_Mutation_p.E54D|CD1E_uc001fsj.2_Missense_Mutation_p.E54D|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.E54D|CD1E_uc001fry.2_Missense_Mutation_p.E54D|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.E54D|CD1E_uc009wsv.2_Intron|CD1E_uc001frz.2_Missense_Mutation_p.E54D|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	54					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					CACACAGTGAGGGCTCAGGAT	0.572													16	46					0	0	0	0	C	158324270	C	C	158324270	3	2	170	1	0	0	0	0	1	0	0	0	2993	991	35	4	168	4	CD1E	1	158324270	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	768133	158324270	90926351	12	31848											
SLAMF6	114836	broad.mit.edu	37	chr1	160460424	160460424	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaccgaagactatgcatatcCcagaaaccataaacagaatc	19	6	5	11	1	0	3	0	0	0	3	2	4	1	3	3	0	4	1	3	0	8	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:160460424C>A	uc001fwe.1	-	4	758	c.698G>T	c.(697-699)GGG>GTG	p.G233V	SLAMF6_uc001fwd.1_Missense_Mutation_p.G233V|SLAMF6_uc010pjh.1_Missense_Mutation_p.G184V|SLAMF6_uc010pji.1_Missense_Mutation_p.G122V|SLAMF6_uc010pjj.1_Missense_Mutation_p.G122V	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	233	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			TATGCATATCCCAGAAACCAT	0.368													19	39					5.35267e-07	6.13751e-07	1	0	A	160460424	A	A	160460424	3	1	170	1	0	0	0	0	1	0	0	0	14433	623	22	4	320	4	SLAMF6	1	160460424	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	2136154	160460424	88790197	13	31849											
C1orf129	80133	broad.mit.edu	37	chr1	170941012	170941012	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcacctcctctacattgcaCggtgtcagaacggtaagaac	11	9	9	12	2	3	2	2	0	1	2	4	2	4	2	2	2	4	2	2	2	4	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:170941012C>A	uc001ghg.2	+	8	734	c.604C>A	c.(604-606)CGG>AGG	p.R202R	C1orf129_uc009wvy.2_Silent_p.R9R|C1orf129_uc010plz.1_Silent_p.R202R	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	202							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTACATTGCACGGTGTCAGAA	0.458													51	135					3.19069e-20	4.39281e-20	1	0	A	170941012	A	A	170941012	2	1	170	1	0	0	0	0	0	0	0	1	2005	527	19	3		3	C1orf129	1	170941012	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	10480588	170941012	78309609	14	31850											
TNR	7143	broad.mit.edu	37	chr1	175375752	175375752	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accctttctgtggtgacctcCagctgacactctgaaggctt	7	12	9	13	0	2	3	0	3	2	0	3	3	3	3	3	2	1	2	3	2	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:175375752C>A	uc001gkp.1	-	1	180	c.99G>T	c.(97-99)CTG>CTT	p.L33L	TNR_uc009wwu.1_Silent_p.L33L|TNR_uc010pmz.1_Silent_p.L33L	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	33					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TGGTGACCTCCAGCTGACACT	0.537													53	72					1.4709e-25	2.08378e-25	1	0	A	175375752	A	A	175375752	2	1	170	1	0	0	0	0	0	0	0	1	16404	581	21	4		4	TNR	1	175375752	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	4434740	175375752	73874869	15	31851											
QSOX1	5768	broad.mit.edu	37	chr1	180151443	180151443	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccggaatggctctgtctcCcgagtccccgtgtgagtatc	5	12	11	13	3	2	1	0	1	2	0	6	3	4	2	4	2	0	2	4	2	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:180151443C>A	uc001gnz.2	+	6	816	c.741C>A	c.(739-741)TCC>TCA	p.S247S	QSOX1_uc001gny.2_Silent_p.S247S|QSOX1_uc001goa.2_Silent_p.S247S|QSOX1_uc001gob.1_RNA	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	247					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						GCTCTGTCTCCCGAGTCCCCG	0.602													28	69					1.39806e-14	1.83436e-14	1	0	A	180151443	A	A	180151443	2	1	170	1	0	0	0	0	0	0	0	1	12948	610	22	4		4	QSOX1	1	180151443	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	4775691	180151443	69099178	16	31852											
FAM129A	116496	broad.mit.edu	37	chr1	184868311	184868311	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaccaaatatccatggcttaCcttggtcttcaaaaactgtg	13	12	6	10	0	2	0	1	0	1	0	3	0	3	0	3	2	3	1	3	2	6	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:184868311C>T	uc001gra.2	-	2	380	c.186_splice	c.e2+1	p.K62_splice	FAM129A_uc009wyh.1_Splice_Site_p.K62_splice|FAM129A_uc009wyi.1_Splice_Site	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2						negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						CCATGGCTTACCTTGGTCTTC	0.393													6	81					0	0	0	0	T	184868311	T	T	184868311	5	4	170	1	0	0	0	0	0	0	1	0	5464	521	18	4	2651	4	FAM129A	1	184868311	Splice_Site	SNP	C	TCGA-CV-5432-01A-02D-1683-08	4716868	184868311	64382310	17	31853											
PRG4	10216	broad.mit.edu	37	chr1	186276244	186276244	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctacacccaccactcccAaggagcctgcacccaccacc	11	3	5	22	0	0	0	0	0	0	0	1	1	1	1	8	1	4	1	8	1	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:186276244A>G	uc001gru.3	+	7	1444	c.1393A>G	c.(1393-1395)AAG>GAG	p.K465E	PRG4_uc001grt.3_Missense_Mutation_p.K424E|PRG4_uc009wyl.2_Missense_Mutation_p.K372E|PRG4_uc009wym.2_Missense_Mutation_p.K331E|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	465	16; approximate.|59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CACCACTCCCAAGGAGCCTGC	0.657													7	33					0	0	0	0	G	186276244	G	G	186276244	3	3	170	1	0	0	0	0	1	0	0	0	12543	131	5	5	1415	5	PRG4	1	186276244	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	1407933	186276244	62974377	18	31854											
PTPRC	5788	broad.mit.edu	37	chr1	198687403	198687403	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgatttccgtgtaaaagatcTtcaatattcaacagactaca	15	12	5	9	2	3	2	2	0	1	2	4	3	4	2	1	0	2	1	1	0	6	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:198687403T>G	uc001gur.1	+	14	1805	c.1625T>G	c.(1624-1626)CTT>CGT	p.L542R	PTPRC_uc001gus.1_Missense_Mutation_p.L494R|PTPRC_uc001gut.1_Missense_Mutation_p.L381R|PTPRC_uc009wzf.1_Missense_Mutation_p.L430R|PTPRC_uc010ppg.1_Missense_Mutation_p.L478R	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	542	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GTAAAAGATCTTCAATATTCA	0.343													9	8					0	0	0	0	G	198687403	G	G	198687403	3	3	170	1	0	0	0	0	1	0	0	0	12862	1609	56	5	1686	5	PTPRC	1	198687403	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	12411159	198687403	50563218	19	31855											
PTPRC	5788	broad.mit.edu	37	chr1	198713288	198713288	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atctacataacatgaagaaaAgggatccacccagtgagccg	16	6	9	10	1	1	3	0	2	1	1	2	4	2	4	3	1	3	0	3	1	5	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:198713288A>T	uc001gur.1	+	26	2977	c.2797A>T	c.(2797-2799)AGG>TGG	p.R933W	PTPRC_uc001gus.1_Missense_Mutation_p.R885W|PTPRC_uc001gut.1_Missense_Mutation_p.R772W	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	933	Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CATGAAGAAAAGGGATCCACC	0.333													10	26					0	0	0	0	T	198713288	T	T	198713288	3	4	170	1	0	0	0	0	1	0	0	0	12862	63	3	5	2906	5	PTPRC	1	198713288	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	25885	198713288	50537333	20	31856											
IPO9	55705	broad.mit.edu	37	chr1	201821282	201821282	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccacttgttgctcctgtcAttctcccagagatgtataag	8	14	8	11	0	2	1	1	0	1	1	4	2	3	1	3	0	2	3	3	0	2	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:201821282A>G	uc001gwz.2	+	5	615	c.565A>G	c.(565-567)ATT>GTT	p.I189V		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	189					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						TGCTCCTGTCATTCTCCCAGA	0.403													10	41					0	0	0	0	G	201821282	G	G	201821282	3	3	170	1	0	0	0	0	1	0	0	0	7838	217	8	5	583	5	IPO9	1	201821282	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	3107994	201821282	47429339	21	31857											
CR1	1378	broad.mit.edu	37	chr1	207739242	207739242	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctggaatggaaagcctttGgaatagcagtgttccagtgt	10	11	14	6	0	0	0	0	0	0	0	1	3	1	3	2	4	2	3	2	4	4	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:207739242G>T	uc001hfy.2	+	16	2716	c.2576G>T	c.(2575-2577)TGG>TTG	p.W859L	CR1_uc009xcl.1_Intron|CR1_uc001hfx.2_Missense_Mutation_p.W1309L|CR1_uc009xck.1_Intron	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	859	Extracellular (Potential).|Sushi 13.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						GAAAGCCTTTGGAATAGCAGT	0.433													13	57					6.31663e-08	7.46163e-08	1	0	T	207739242	T	T	207739242	3	4	170	1	0	0	0	0	1	0	0	0	3855	1357	47	4	4020	4	CR1	1	207739242	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	5917960	207739242	41511379	22	31858											
HIST3H3	8290	broad.mit.edu	37	chr1	228612628	228612628	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tagccctcctaggcccgctcCccgcggatacggcgtgccag	5	6	12	18	5	0	0	0	0	0	0	2	1	2	1	6	3	3	1	6	3	3	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:228612628C>A	uc001hsx.1	-	1	399	c.399G>T	c.(397-399)GGG>GGT	p.G133G		NM_003493	NP_003484	Q16695	H31T_HUMAN	histone cluster 3, H3	133					nucleosome assembly|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		Prostate(94;0.0724)				AGGCCCGCTCCCCGCGGATAC	0.587													16	23					3.32936e-07	3.84006e-07	1	0	A	228612628	A	A	228612628	2	1	170	1	0	0	0	0	0	0	0	1	7223	610	22	4		4	HIST3H3	1	228612628	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	20873386	228612628	20637993	23	31859											
KCNK1	3775	broad.mit.edu	37	chr1	233750265	233750265	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgccagcaccgtgctctcCaccacaggtagggtatcctg	7	9	10	15	2	1	0	0	0	1	0	4	0	2	0	5	2	2	4	5	2	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:233750265C>T	uc010pxo.1	+	1	516	c.348C>T	c.(346-348)TCC>TCT	p.S116S		NM_002245	NP_002236	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	116						voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	CCGTGCTCTCCACCACAGGTA	0.582													3	10					0	0	0	0	T	233750265	T	T	233750265	2	4	170	1	0	0	0	0	0	0	0	1	8097	581	21	4		4	KCNK1	1	233750265	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	5137637	233750265	15500356	24	31860											
CHML	1122	broad.mit.edu	37	chr1	241798800	241798800	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatagtttcatccttcttgCgaagagtgatggcttcttct	8	16	9	8	1	4	2	1	1	3	1	5	4	5	2	1	1	1	2	1	1	3	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:241798800C>G	uc001hzd.2	-	1	433	c.269G>C	c.(268-270)CGC>CCC	p.R90P	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	90					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			ATCCTTCTTGCGAAGAGTGAT	0.438													82	148					0	0	0	0	G	241798800	G	G	241798800	3	3	170	1	0	0	0	0	1	0	0	0	3366	768	27	3	1705	3	CHML	1	241798800	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	8048535	241798800	7451821	25	31861											
NLRP3	114548	broad.mit.edu	37	chr1	247593033	247593033	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgaaacgctccagcatcCtggctgtaacattcggagat	10	10	11	10	2	0	2	0	1	0	1	3	3	2	2	2	2	3	4	2	2	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:247593033C>T	uc001icr.2	+	6	2441	c.2303C>T	c.(2302-2304)CCT>CTT	p.P768L	NLRP3_uc001ics.2_Missense_Mutation_p.P768L|NLRP3_uc001icu.2_Missense_Mutation_p.P768L|NLRP3_uc001icw.2_Intron|NLRP3_uc001icv.2_Intron|NLRP3_uc010pyw.1_Missense_Mutation_p.P766L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	768					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CTCCAGCATCCTGGCTGTAAC	0.498													11	42					0	0	0	0	T	247593033	T	T	247593033	3	4	170	1	0	0	0	0	1	0	0	0	10532	681	24	4	2317	4	NLRP3	1	247593033	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	5794233	247593033	1657588	26	31862											
OR2W5	441932	broad.mit.edu	37	chr1	247655019	247655019	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaaaccatgctggtagaagCgattcacctttgccctgggg	9	9	13	10	1	1	1	1	0	0	1	1	3	1	2	3	4	4	2	3	4	3	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:247655019C>A	uc001icz.1	+	1	590	c.590C>A	c.(589-591)GCG>GAG	p.A197E		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CTGGTAGAAGCGATTCACCTT	0.582													24	91					7.38237e-10	9.1057e-10	1	0	A	247655019	A	A	247655019	3	1	170	1	0	0	0	0	1	0	0	0	11088	768	27	3	592	3	OR2W5	1	247655019	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	61986	247655019	1595602	27	31863											
OR2T12	127064	broad.mit.edu	37	chr1	248458823	248458823	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaggacttggtgggctcTggtgtggttaaagagtccta	9	11	16	5	0	1	2	0	0	1	2	2	4	2	3	1	5	0	2	1	5	4	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:248458823T>C	uc010pzj.1	-	1	58	c.58A>G	c.(58-60)AGA>GGA	p.R20G		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TGGTGGGCTCTGGTGTGGTTA	0.468													31	47					0	0	0	0	C	248458823	C	C	248458823	3	2	170	1	0	0	0	0	1	0	0	0	11073	1588	55	5	907	5	OR2T12	1	248458823	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	803804	248458823	791798	28	31864											
OR2T4	127074	broad.mit.edu	37	chr1	248525119	248525119	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaatgctgtcctgatcctTctgatacactgtgacgccca	9	11	9	12	1	1	3	0	3	1	0	3	4	3	4	3	1	2	1	3	1	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:248525119T>C	uc001ieh.1	+	1	237	c.237T>C	c.(235-237)CTT>CTC	p.L79L		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	79	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCCTGATCCTTCTGATACACT	0.468													86	108					0	0	0	0	C	248525119	C	C	248525119	2	2	170	1	0	0	0	0	0	0	0	1	11081	1770	62	5		5	OR2T4	1	248525119	Silent	SNP	T	TCGA-CV-5432-01A-02D-1683-08	66296	248525119	725502	29	31865											
OR2T4	127074	broad.mit.edu	37	chr1	248525375	248525375	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctgccatcctctccgttacCctgtcctcatgaaccatagg	7	12	6	16	1	3	1	1	1	2	0	6	1	5	1	6	1	3	1	6	1	3	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr1:248525375C>G	uc001ieh.1	+	1	493	c.493C>G	c.(493-495)CCT>GCT	p.P165A		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	165	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCTCCGTTACCCTGTCCTCAT	0.522													33	130					0	0	0	0	G	248525375	G	G	248525375	3	3	170	1	0	0	0	0	1	0	0	0	11081	623	22	4	495	4	OR2T4	1	248525375	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	256	248525375	725246	30	31866											
PXDN	7837	broad.mit.edu	37	chr2	1642655	1642655	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggtcttctgcatttccAgaacaaactctctgaagtca	11	13	7	10	0	4	3	1	2	3	1	6	3	5	3	1	1	3	1	1	1	3	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:1642655A>G	uc002qxa.2	-	21	4233	c.4169T>C	c.(4168-4170)CTG>CCG	p.L1390P		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1390					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CTGCATTTCCAGAACAAACTC	0.562													11	42					0	0	0	0	G	1642655	G	G	1642655	3	3	170	1	0	0	0	0	1	0	0	0	12912	188	7	5	282	5	PXDN	2	1642655	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08		1642655	241556718	31	31867											
PXDN	7837	broad.mit.edu	37	chr2	1670117	1670117	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggcgtgatgttcacccgcGggtcaactggcaagggtgtg	8	8	16	9	3	2	1	2	1	0	0	2	1	2	1	1	4	1	2	1	4	3	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:1670117G>T	uc002qxa.2	-	10	1224	c.1160C>A	c.(1159-1161)CCG>CAG	p.P387Q	PXDN_uc002qxb.1_Missense_Mutation_p.P387Q|PXDN_uc002qxc.1_Missense_Mutation_p.P204Q	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	387	Ig-like C2-type 2.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GTTCACCCGCGGGTCAACTGG	0.632													6	23					8.12818e-05	8.82811e-05	1	0	T	1670117	T	T	1670117	3	4	170	1	0	0	0	0	1	0	0	0	12912	1116	39	3	3335	3	PXDN	2	1670117	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	27462	1670117	241529256	32	31868											
NBAS	51594	broad.mit.edu	37	chr2	15496497	15496497	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagcgaagtgcctgctccacTaaaaggattagaacctgtcc	13	8	9	11	1	0	1	0	0	0	1	2	3	2	2	4	1	4	1	4	1	6	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:15496497T>A	uc002rcc.1	-	33	3887	c.3861A>T	c.(3859-3861)TTA>TTT	p.L1287F	NBAS_uc010exl.1_Missense_Mutation_p.L359F|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1287										ovary(2)|liver(1)|skin(1)	4						CCTGCTCCACTAAAAGGATTA	0.453													3	34					0	0	0	0	A	15496497	A	A	15496497	3	1	170	1	0	0	0	0	1	0	0	0	10239	1519	53	5	3334	5	NBAS	2	15496497	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	13826380	15496497	227702876	33	31869											
PRKD3	23683	broad.mit.edu	37	chr2	37505011	37505011	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgtatttgattactgaccaGgttatccctgctggtgtaat	9	16	9	7	0	0	2	0	2	0	0	1	2	1	2	2	2	2	4	2	2	4	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:37505011G>T	uc002rqd.2	-	8	1849	c.1294C>A	c.(1294-1296)CTG>ATG	p.L432M	PRKD3_uc002rqe.1_Missense_Mutation_p.L32M|PRKD3_uc002rqf.1_Missense_Mutation_p.L432M	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	432	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				TTACTGACCAGGTTATCCCTG	0.378													83	43					1.13027e-35	1.6368e-35	1	0	T	37505011	T	T	37505011	3	4	170	1	0	0	0	0	1	0	0	0	12582	991	35	4	1422	4	PRKD3	2	37505011	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	22008514	37505011	205694362	34	31870											
KCNG3	170850	broad.mit.edu	37	chr2	42720364	42720364	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agatcatctcgttgtagaagGagagctcgcacatccgcggc	10	8	12	11	4	2	3	1	0	1	3	5	4	3	3	1	2	1	4	1	2	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:42720364G>C	uc002rsn.2	-	1	874	c.278C>G	c.(277-279)TCC>TGC	p.S93C	MTA3_uc002rso.1_5'Flank|KCNG3_uc002rsm.2_Missense_Mutation_p.S93C	NM_133329	NP_579875	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G,	93	Cytoplasmic (Potential).					endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)	1						GTTGTAGAAGGAGAGCTCGCA	0.647													21	8					0	0	0	0	C	42720364	C	C	42720364	3	2	170	1	0	0	0	0	1	0	0	0	8068	1174	41	2	1040	2	KCNG3	2	42720364	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	5215353	42720364	200479009	35	31871											
MTIF2	4528	broad.mit.edu	37	chr2	55470638	55470638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcttttctttctaaaaacCgtagaattgatctcttcttc	9	19	4	9	1	5	2	0	1	5	1	7	2	5	2	1	0	1	2	1	0	5	9			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:55470638C>T	uc002ryn.2	-	13	2215	c.1478G>A	c.(1477-1479)CGG>CAG	p.R493Q	MTIF2_uc010yox.1_Missense_Mutation_p.R162Q|MTIF2_uc002ryo.2_Missense_Mutation_p.R493Q	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	493					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						TTCTAAAAACCGTAGAATTGA	0.343													47	77					0	0	0	0	T	55470638	T	T	55470638	3	4	170	1	0	0	0	0	1	0	0	0	9987	652	23	1	725	1	MTIF2	2	55470638	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	12750274	55470638	187728735	36	31872											
EHBP1	23301	broad.mit.edu	37	chr2	63176055	63176055	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaaaagcttcaaactctaGacatcggtagtaacttggag	16	9	8	8	1	2	1	1	0	1	1	3	2	2	2	0	2	4	3	0	2	7	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:63176055G>T	uc002sby.2	+	14	2661	c.2179G>T	c.(2179-2181)GAC>TAC	p.D727Y	EHBP1_uc010fcp.2_Missense_Mutation_p.D692Y|EHBP1_uc002sbz.2_Missense_Mutation_p.D692Y|EHBP1_uc002scb.2_Missense_Mutation_p.D692Y	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	727						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TCAAACTCTAGACATCGGTAG	0.353									Hereditary_Prostate_Cancer				24	33					2.27525e-19	3.12149e-19	1	0	T	63176055	T	T	63176055	3	4	170	1	0	0	0	0	1	0	0	0	4997	942	33	2	2229	2	EHBP1	2	63176055	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	7705417	63176055	180023318	37	31873											
TTC31	64427	broad.mit.edu	37	chr2	74719855	74719855	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccgagagctccgctcttGccttctccacctcacactgg	6	9	8	18	2	3	1	1	0	2	1	5	2	4	1	5	1	3	2	5	1	0	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:74719855G>C	uc002slt.2	+	12	1267	c.1244G>C	c.(1243-1245)TGC>TCC	p.C415S	TTC31_uc010yrv.1_Intron|TTC31_uc002slu.2_Missense_Mutation_p.C269S	NM_022492	NP_071937	Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	415							binding				0						CTCCGCTCTTGCCTTCTCCAC	0.597													21	62					0	0	0	0	C	74719855	C	C	74719855	3	2	170	1	0	0	0	0	1	0	0	0	16768	1319	46	4	1290	4	TTC31	2	74719855	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	11543800	74719855	168479518	38	31874											
SEMA4F	10505	broad.mit.edu	37	chr2	74906906	74906906	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccatgggcgcttatgcctGtgaatgtcaggagggtgggg	6	9	19	7	1	1	1	1	1	0	0	1	2	1	2	2	6	1	1	2	6	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:74906906G>T	uc002sna.1	+	14	1994	c.1883G>T	c.(1882-1884)TGT>TTT	p.C628F	SEMA4F_uc010ffr.1_Missense_Mutation_p.C240F|SEMA4F_uc002snb.1_Missense_Mutation_p.C240F|SEMA4F_uc002snc.1_Missense_Mutation_p.C473F	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	628	Ig-like C2-type.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GCTTATGCCTGTGAATGTCAG	0.662													25	84					8.24728e-16	1.10058e-15	1	0	T	74906906	T	T	74906906	3	4	170	1	0	0	0	0	1	0	0	0	14100	1377	48	4	1937	4	SEMA4F	2	74906906	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	187051	74906906	168292467	39	31875											
LRRTM4	80059	broad.mit.edu	37	chr2	77745756	77745756	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgctcatactcttgctcTgcgccaggaatctgaaaccc	10	10	7	14	1	4	1	1	1	3	0	4	2	4	2	2	1	5	2	2	1	3	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:77745756T>G	uc002snr.2	-	3	1654	c.1239A>C	c.(1237-1239)GCA>GCC	p.A413A	LRRTM4_uc002snq.2_Silent_p.A413A|LRRTM4_uc002sns.2_Silent_p.A413A|LRRTM4_uc002snt.2_Silent_p.A414A	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	413	Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		ACTCTTGCTCTGCGCCAGGAA	0.473													36	28					0	0	0	0	G	77745756	G	G	77745756	2	3	170	1	0	0	0	0	0	0	0	1	9092	1567	55	5		5	LRRTM4	2	77745756	Silent	SNP	T	TCGA-CV-5432-01A-02D-1683-08	2838850	77745756	165453617	40	31876											
CNNM4	26504	broad.mit.edu	37	chr2	97464940	97464940	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacccgaaataagccggccGactacttcatcctcatcctg	11	8	6	16	3	2	0	2	0	0	0	4	2	4	0	5	1	2	0	5	1	3	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:97464940G>T	uc002swx.2	+	4	1926	c.1828G>T	c.(1828-1830)GAC>TAC	p.D610Y	CNNM4_uc010yuy.1_Missense_Mutation_p.D97Y	NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	610					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|ovary(1)	3						TAAGCCGGCCGACTACTTCAT	0.592													32	54					6.19805e-25	8.74887e-25	1	0	T	97464940	T	T	97464940	3	4	170	1	0	0	0	0	1	0	0	0	3630	1058	37	3	1842	3	CNNM4	2	97464940	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	19719184	97464940	145734433	41	31877											
RANBP2	5903	broad.mit.edu	37	chr2	109367719	109367719	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattttttaattttatttcaGgtgctattcgagcacataat	12	19	5	5	1	1	0	1	0	0	0	2	1	1	0	0	1	2	2	0	1	5	9			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:109367719G>T	uc002tem.3	+	10	1400	c.1274_splice	c.e10-1	p.G425_splice		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TTTTATTTCAGGTGCTATTCG	0.338													77	142					8.50452e-49	1.24077e-48	1	0	T	109367719	T	T	109367719	5	4	170	1	0	0	0	0	0	0	1	0	13093	1014	35	4	1311	4	RANBP2	2	109367719	Splice_Site	SNP	G	TCGA-CV-5432-01A-02D-1683-08	11902779	109367719	133831654	42	31878											
DPP10	57628	broad.mit.edu	37	chr2	116283477	116283477	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttttttctttttctaggtaAccttcaaagcatcaagacat	11	18	4	8	0	4	1	2	0	2	1	4	1	4	1	1	1	2	2	1	1	4	8			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:116283477A>T	uc002tla.1	+	5	827	c.370A>T	c.(370-372)ACC>TCC	p.T124S	DPP10_uc002tlb.1_Missense_Mutation_p.T74S|DPP10_uc002tlc.1_Missense_Mutation_p.T120S|DPP10_uc002tle.2_Missense_Mutation_p.T128S|DPP10_uc002tlf.1_Missense_Mutation_p.T117S	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	124	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TTTCTAGGTAACCTTCAAAGC	0.279													6	41					0	0	0	0	T	116283477	T	T	116283477	3	4	170	1	0	0	0	0	1	0	0	0	4749	43	2	5	559	5	DPP10	2	116283477	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	6915758	116283477	126915896	43	31879											
DPP10	57628	broad.mit.edu	37	chr2	116497324	116497324	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttattctagaggaactccTgcattctcacatcgcccact	10	13	5	13	1	2	1	1	0	2	1	5	2	3	2	2	1	2	1	2	1	3	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:116497324T>A	uc002tla.1	+	9	1164	c.707T>A	c.(706-708)CTG>CAG	p.L236Q	DPP10_uc002tlb.1_Missense_Mutation_p.L186Q|DPP10_uc002tlc.1_Missense_Mutation_p.L232Q|DPP10_uc002tle.2_Missense_Mutation_p.L240Q|DPP10_uc002tlf.1_Missense_Mutation_p.L229Q	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	236	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						GAGGAACTCCTGCATTCTCAC	0.458													37	42					0	0	0	0	A	116497324	A	A	116497324	3	1	170	1	0	0	0	0	1	0	0	0	4749	1580	55	5	912	5	DPP10	2	116497324	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	213847	116497324	126702049	44	31880											
CNTNAP5	129684	broad.mit.edu	37	chr2	125281880	125281880	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctctcttgtttctcttgcagGcagcaacttgaatgatggcc	7	14	9	11	0	2	2	0	2	2	0	4	2	2	2	1	2	3	4	1	2	2	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:125281880G>A	uc002tno.2	+	9	1689	c.1325G>A	c.(1324-1326)GGC>GAC	p.G442D	CNTNAP5_uc010flu.2_Missense_Mutation_p.G443D	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	442	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCTCTTGCAGGCAGCAACTTG	0.547													26	27					0	0	0	0	A	125281880	A	A	125281880	3	1	170	1	0	0	0	0	1	0	0	0	3665	1217	42	4	1359	4	CNTNAP5	2	125281880	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	8784556	125281880	117917493	45	31881											
THSD7B	80731	broad.mit.edu	37	chr2	138414459	138414459	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgtgggccgccagtctaGatcaaggacttttataattc	10	12	10	9	1	2	1	1	0	1	1	3	3	2	2	2	2	0	0	2	2	4	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:138414459G>T	uc002tva.1	+	22	4112	c.4112G>T	c.(4111-4113)AGA>ATA	p.R1371I	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CGCCAGTCTAGATCAAGGACT	0.463													17	75					6.49762e-13	8.35714e-13	1	0	T	138414459	T	T	138414459	3	4	170	1	0	0	0	0	1	0	0	0	15946	942	33	2	4197	2	THSD7B	2	138414459	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	13132579	138414459	104784914	46	31882											
LRP1B	53353	broad.mit.edu	37	chr2	141709504	141709504	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggttagtggctcacaagttgGgaattctgtgaaagatataa	13	12	12	4	0	2	2	1	1	1	1	2	3	2	3	0	3	0	3	0	3	6	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:141709504G>T	uc002tvj.1	-	19	3865	c.2893C>A	c.(2893-2895)CCA>ACA	p.P965T	LRP1B_uc010fnl.1_Missense_Mutation_p.P147T	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	965	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCACAAGTTGGGAATTCTGTG	0.398										TSP Lung(27;0.18)			7	30					8.12818e-05	8.82811e-05	1	0	T	141709504	T	T	141709504	3	4	170	1	0	0	0	0	1	0	0	0	9005	1232	43	4	11198	4	LRP1B	2	141709504	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	3295045	141709504	101489869	47	31883											
ZEB2	9839	broad.mit.edu	37	chr2	145157042	145157042	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatgttgtggttctcaatcAttttgtcatcagtgaccaaa	11	16	7	7	0	4	1	4	1	1	0	5	1	4	1	1	1	0	2	1	1	3	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:145157042A>G	uc002tvu.2	-	8	2192	c.1712T>C	c.(1711-1713)ATG>ACG	p.M571T	ZEB2_uc002tvv.2_Missense_Mutation_p.M565T|ZEB2_uc010zbm.1_Missense_Mutation_p.M542T|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.M600T	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	571						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GTTCTCAATCATTTTGTCATC	0.408													26	86					0	0	0	0	G	145157042	G	G	145157042	3	3	170	1	0	0	0	0	1	0	0	0	17691	217	8	5	1944	5	ZEB2	2	145157042	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	3447538	145157042	98042331	48	31884											
NEB	4703	broad.mit.edu	37	chr2	152486055	152486055	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagggtgttgctactcacatCactgataacgtccctggagg	9	11	11	10	1	2	1	2	1	0	0	3	2	3	2	1	3	3	2	1	3	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:152486055C>A	uc010fnx.2	-	64	9291	c.9100G>T	c.(9100-9102)GAT>TAT	p.D3034Y	NEB_uc002txu.2_Missense_Mutation_p.D381Y	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3034	Nebulin 82.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTACTCACATCACTGATAACG	0.448													12	61					5.50884e-06	6.11919e-06	1	0	A	152486055	A	A	152486055	3	1	170	1	0	0	0	0	1	0	0	0	10356	826	29	2	16317	2	NEB	2	152486055	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	7329013	152486055	90713318	49	31885											
GALNT13	114805	broad.mit.edu	37	chr2	155295167	155295167	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcttggatgtttctagaCtcaatggacctgtaatcatg	9	15	10	7	0	3	1	2	0	1	1	3	3	3	3	1	2	1	3	1	2	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:155295167C>T	uc002tyr.3	+	12	2026	c.1459C>T	c.(1459-1461)CTC>TTC	p.L487F	GALNT13_uc002tyt.3_Missense_Mutation_p.L487F|GALNT13_uc010fod.2_Missense_Mutation_p.T219I|uc002tyu.1_Intron	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	487	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TGTTTCTAGACTCAATGGACC	0.318													15	88					0	0	0	0	T	155295167	T	T	155295167	3	4	170	1	0	0	0	0	1	0	0	0	6246	565	20	4	1497	4	GALNT13	2	155295167	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	2809112	155295167	87904206	50	31886											
FIGN	55137	broad.mit.edu	37	chr2	164467941	164467941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagggagggctgaactgactCcagctttgctggcagtgata	9	9	15	8	0	0	3	0	3	0	0	1	5	1	4	1	3	3	4	1	3	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:164467941C>G	uc002uck.1	-	3	712	c.401G>C	c.(400-402)GGA>GCA	p.G134A		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	134						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						TGAACTGACTCCAGCTTTGCT	0.498													23	66					0	0	0	0	G	164467941	G	G	164467941	3	3	170	1	0	0	0	0	1	0	0	0	5923	855	30	2	1882	2	FIGN	2	164467941	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	9172774	164467941	78731432	51	31887											
SLC38A11	151258	broad.mit.edu	37	chr2	165795989	165795989	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttgctatatttcggtacaAggataaaggcagagtaaagg	14	11	11	5	1	0	1	0	0	0	1	1	2	0	2	0	4	2	4	0	4	8	7			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:165795989A>C	uc002ucv.1	-	7	877	c.340T>G	c.(340-342)TTG>GTG	p.L114V	SLC38A11_uc002ucu.1_Missense_Mutation_p.L92V|SLC38A11_uc002ucw.1_Missense_Mutation_p.L114V	NM_173512	NP_775783	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	114	Extracellular (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						TTTCGGTACAAGGATAAAGGC	0.343													9	48					0	0	0	0	C	165795989	C	C	165795989	3	2	170	1	0	0	0	0	1	0	0	0	14667	69	3	5	908	5	SLC38A11	2	165795989	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	1328048	165795989	77403384	52	31888											
SCN7A	6332	broad.mit.edu	37	chr2	167328890	167328890	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggaaggaaaatgatcctGcccagacacctcttgcaaag	14	6	10	11	1	1	2	0	1	1	1	2	5	2	4	3	2	2	1	3	2	4	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:167328890G>T	uc002udu.1	-	5	636	c.509C>A	c.(508-510)GCA>GAA	p.A170E	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	170					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AAATGATCCTGCCCAGACACC	0.343													3	11					6.4e-05	7.00952e-05	1	0	T	167328890	T	T	167328890	3	4	170	1	0	0	0	0	1	0	0	0	13988	1319	46	4	4623	4	SCN7A	2	167328890	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1532901	167328890	75870483	53	31889											
TTN	7273	broad.mit.edu	37	chr2	179438979	179438979	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaggtctctcttttcaacGatataactggtaattttaaa	13	15	7	6	1	3	0	1	0	2	0	4	2	3	1	0	3	2	1	0	3	7	7			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:179438979G>T	uc010zfg.1	-	275	64400	c.64176C>A	c.(64174-64176)ATC>ATA	p.I21392I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.I15087I|TTN_uc010zfi.1_Silent_p.I15020I|TTN_uc010zfj.1_Silent_p.I14895I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22319							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTTCAACGATATAACTGG	0.413													10	35					1.58986e-06	1.80185e-06	1	0	T	179438979	T	T	179438979	2	4	170	1	0	0	0	0	0	0	0	1	16803	1048	37	3		3	TTN	2	179438979	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	12110089	179438979	63760394	54	31890											
TTN	7273	broad.mit.edu	37	chr2	179474460	179474460	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtagcccgagaaggttcactAatacccgcggcgttctctgc	8	9	11	13	4	2	1	1	0	1	1	3	2	2	1	2	2	3	3	2	2	4	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:179474460A>G	uc010zfg.1	-	221	44210	c.43986T>C	c.(43984-43986)ATT>ATC	p.I14662I	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.I8357I|TTN_uc010zfi.1_Silent_p.I8290I|TTN_uc010zfj.1_Silent_p.I8165I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15589							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGGTTCACTAATACCCGCGG	0.458													100	107					0	0	0	0	G	179474460	G	G	179474460	2	3	170	1	0	0	0	0	0	0	0	1	16803	358	13	5		5	TTN	2	179474460	Silent	SNP	A	TCGA-CV-5432-01A-02D-1683-08	35481	179474460	63724913	55	31891											
TTN	7273	broad.mit.edu	37	chr2	179516662	179516662	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaacttcagcaggaggctCttctagggcaacttcctcag	10	9	9	13	0	4	0	2	0	2	0	5	1	5	1	1	3	3	3	1	3	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:179516662C>T	uc010zfg.1	-	159	32250	c.32026G>A	c.(32026-32028)GAG>AAG	p.E10676K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_5'Flank|TTN_uc002umx.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11603							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAGGAGGCTCTTCTAGGGCA	0.483													5	13					0	0	0	0	T	179516662	T	T	179516662	3	4	170	1	0	0	0	0	1	0	0	0	16803	922	32	2	68575	2	TTN	2	179516662	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	42202	179516662	63682711	56	31892											
TTN	7273	broad.mit.edu	37	chr2	179582094	179582094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggctttagatcaaagaaaGgaggcacttcatgctctgaa	14	9	10	8	0	3	3	2	1	1	2	3	4	3	4	0	3	1	3	0	3	4	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:179582094G>A	uc010zfg.1	-	85	21859	c.21635C>T	c.(21634-21636)CCT>CTT	p.P7212L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P3873L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8139							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCAAAGAAAGGAGGCACTTC	0.403													11	41					0	0	0	0	A	179582094	A	A	179582094	3	1	170	1	0	0	0	0	1	0	0	0	16803	1000	35	4	79262	4	TTN	2	179582094	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	65432	179582094	63617279	57	31893											
TTN	7273	broad.mit.edu	37	chr2	179584098	179584098	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggggctgagccagagactcGgcactccaaaacaactgagg	12	4	13	12	2	0	3	0	2	0	1	2	4	1	3	2	4	3	2	2	4	3	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:179584098G>A	uc010zfg.1	-	80	20511	c.20287C>T	c.(20287-20289)CGA>TGA	p.R6763*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.R3424*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7690							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAGAGACTCGGCACTCCAAA	0.517													11	68					0	0	0	0	A	179584098	A	A	179584098	4	1	170	1	0	0	0	0	0	1	0	0	16803	1124	39	1	80630	1	TTN	2	179584098	Nonsense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	2004	179584098	63615275	58	31894											
TTN	7273	broad.mit.edu	37	chr2	179654130	179654130	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcttgtctagtagccataGtttctctagttctcagtatt	7	19	7	8	0	4	0	1	0	4	0	6	0	4	0	1	0	1	5	1	0	5	10			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:179654130G>A	uc010zfg.1	-	13	2257	c.2033C>T	c.(2032-2034)ACT>ATT	p.T678I	TTN_uc010zfh.1_Missense_Mutation_p.T632I|TTN_uc010zfi.1_Missense_Mutation_p.T632I|TTN_uc010zfj.1_Missense_Mutation_p.T632I|TTN_uc002unb.2_Missense_Mutation_p.T678I|TTN_uc010frg.1_Missense_Mutation_p.T260I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	678							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTAGCCATAGTTTCTCTAGT	0.373													35	64					0	0	0	0	A	179654130	A	A	179654130	3	1	170	1	0	0	0	0	1	0	0	0	16803	1029	36	4	109355	4	TTN	2	179654130	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	70032	179654130	63545243	59	31895											
TTN	7273	broad.mit.edu	37	chr2	179659664	179659664	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtacctctttagcaccagtGgcaacagcctctgctgcgta	9	10	9	13	1	2	0	0	0	2	0	2	0	2	0	3	1	6	5	3	1	4	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:179659664G>A	uc010zfg.1	-	7	1454	c.1230C>T	c.(1228-1230)GCC>GCT	p.A410A	TTN_uc010zfh.1_Silent_p.A410A|TTN_uc010zfi.1_Silent_p.A410A|TTN_uc010zfj.1_Silent_p.A410A|TTN_uc002unb.2_Silent_p.A410A|TTN_uc010frg.1_Silent_p.A84A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	410							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGCACCAGTGGCAACAGCCT	0.498													25	44					0	0	0	0	A	179659664	A	A	179659664	2	1	170	1	0	0	0	0	0	0	0	1	16803	1335	47	4		4	TTN	2	179659664	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	5534	179659664	63539709	60	31896											
TTN	7273	broad.mit.edu	37	chr2	179665398	179665398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcgttgaacgaagttgggtgGtgctgtctcagctgcgggga	6	11	17	7	3	1	1	1	1	1	0	3	3	1	2	0	4	4	4	0	4	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:179665398G>A	uc002und.2	-	4	532	c.307C>T	c.(307-309)CCA>TCA	p.P103S	TTN_uc010zfg.1_Missense_Mutation_p.P103S|TTN_uc010zfh.1_Missense_Mutation_p.P103S|TTN_uc010zfi.1_Missense_Mutation_p.P103S|TTN_uc010zfj.1_Missense_Mutation_p.P103S|TTN_uc002unb.2_Missense_Mutation_p.P103S			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	103							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGTTGGGTGGTGCTGTCTCA	0.493													29	34					0	0	0	0	A	179665398	A	A	179665398	3	1	170	1	0	0	0	0	1	0	0	0	16803	1261	44	4	111117	4	TTN	2	179665398	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	5734	179665398	63533975	61	31897											
FN1	2335	broad.mit.edu	37	chr2	216235085	216235085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtctttcagtgcctccactAtgacgttgtaggtggcacct	6	13	11	11	1	2	1	1	1	1	0	3	1	3	1	3	3	1	3	3	3	2	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:216235085A>G	uc002vfa.2	-	41	7051	c.6785T>C	c.(6784-6786)ATA>ACA	p.I2262T	FN1_uc002vfb.2_Missense_Mutation_p.I2050T|FN1_uc002vfc.2_Missense_Mutation_p.I2025T|FN1_uc002vfd.2_Missense_Mutation_p.I2206T|FN1_uc002vfe.2_Missense_Mutation_p.I2140T|FN1_uc002vff.2_Missense_Mutation_p.I2115T|FN1_uc002vfg.2_Missense_Mutation_p.I2081T|FN1_uc002vfh.2_Missense_Mutation_p.I1961T|FN1_uc002vfi.2_Missense_Mutation_p.I2231T|FN1_uc002vfj.2_Missense_Mutation_p.I2052T|FN1_uc002vez.2_Missense_Mutation_p.I425T|FN1_uc010zjp.1_Missense_Mutation_p.I799T|FN1_uc002vfk.1_RNA|FN1_uc010fva.1_Intron|FN1_uc010fvb.1_Intron|FN1_uc010fvc.1_Missense_Mutation_p.I504T|FN1_uc010fvd.1_Missense_Mutation_p.I322T	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	2171	Fibronectin type-III 16.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCCTCCACTATGACGTTGTA	0.502													12	30					0	0	0	0	G	216235085	G	G	216235085	3	3	170	1	0	0	0	0	1	0	0	0	5994	449	16	5	672	5	FN1	2	216235085	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	36569687	216235085	26964288	62	31898											
INHA	3623	broad.mit.edu	37	chr2	220437168	220437168	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgccaggggctggagctGgcccgggaacttgttctggc	5	8	17	11	1	1	0	0	0	1	0	1	2	1	2	2	6	4	4	2	6	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:220437168G>A	uc002vmk.1	+	1	216	c.72G>A	c.(70-72)CTG>CTA	p.L24L	OBSL1_uc010fwk.2_5'Flank|OBSL1_uc002vmi.2_5'Flank|OBSL1_uc002vmj.2_5'Flank	NM_002191	NP_002182	P05111	INHA_HUMAN	inhibin alpha subunit precursor	24					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GGCTGGAGCTGGCCCGGGAAC	0.662											OREG0003991	type=REGULATORY REGION|Gene=BC045558|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	21	20					0	0	0	0	A	220437168	A	A	220437168	2	1	170	1	0	0	0	0	0	0	0	1	7779	1335	47	4		4	INHA	2	220437168	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	4202083	220437168	22762205	63	31899											
CUL3	8452	broad.mit.edu	37	chr2	225365205	225365205	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaacaccacctaaagatacCtatgtaaaacagaaagagat	20	7	5	9	0	1	3	1	0	0	3	1	4	1	3	3	0	3	1	3	0	8	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:225365205C>A	uc002vny.2	-	11	1870	c.1486_splice	c.e11-1	p.V496_splice	CUL3_uc010zls.1_Splice_Site_p.V430_splice|CUL3_uc010fwy.1_Splice_Site_p.V502_splice|CUL3_uc002vnz.1_Splice_Site	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3						cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		CTAAAGATACCTATGTAAAAC	0.428													17	57					1.62849e-17	2.2109e-17	1	0	A	225365205	A	A	225365205	5	1	170	1	0	0	0	0	0	0	1	0	4073	695	24	4	845	4	CUL3	2	225365205	Splice_Site	SNP	C	TCGA-CV-5432-01A-02D-1683-08	4928037	225365205	17834168	64	31900											
COL4A4	1286	broad.mit.edu	37	chr2	227924319	227924319	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcacctccaaaacccggatCtcccatgtcaccacgaaaac	13	7	4	17	2	3	0	2	0	1	0	5	2	4	1	5	1	2	0	5	1	4	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:227924319C>A	uc010zlt.1	-	28	2839	c.2185G>T	c.(2185-2187)GAT>TAT	p.D729Y		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	729	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		AAACCCGGATCTCCCATGTCA	0.453													23	71					0.000229342	0.000245678	1	0	A	227924319	A	A	227924319	3	1	170	1	0	0	0	0	1	0	0	0	3708	913	32	2	2971	2	COL4A4	2	227924319	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	2559114	227924319	15275054	65	31901											
CAPN10	11132	broad.mit.edu	37	chr2	241530316	241530316	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tttggcagtttggacgctggGtggaggtgaccacagatgac	8	10	16	7	1	0	3	0	2	0	1	0	5	0	5	1	5	0	3	1	5	0	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr2:241530316G>T	uc002vzk.1	+	3	542	c.358G>T	c.(358-360)GTG>TTG	p.V120L	CAPN10_uc010zoh.1_Missense_Mutation_p.V120L|CAPN10_uc002vzl.1_Missense_Mutation_p.V120L|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_5'UTR|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	120	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		TGGACGCTGGGTGGAGGTGAC	0.617													12	36					2.80697e-09	3.41909e-09	1	0	T	241530316	T	T	241530316	3	4	170	1	0	0	0	0	1	0	0	0	2635	1261	44	4	368	4	CAPN10	2	241530316	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	13605997	241530316	1669057	66	31902											
ZCWPW2	152098	broad.mit.edu	37	chr3	28520395	28520395	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attctcatgagcaaagactgGaaatgtgctgcctatcaaaa	15	10	8	8	0	2	2	2	1	1	1	3	3	2	3	1	1	3	2	1	1	5	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:28520395G>T	uc003ceh.2	+	5	751	c.583G>T	c.(583-585)GAA>TAA	p.E195*	ZCWPW2_uc003cei.2_Nonsense_Mutation_p.E195*|ZCWPW2_uc010hfo.2_5'UTR	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	195							zinc ion binding			ovary(2)	2						GCAAAGACTGGAAATGTGCTG	0.299													3	29					0.000602214	0.000631276	1	0	T	28520395	T	T	28520395	4	4	170	1	0	0	0	0	0	1	0	0	17665	1175	41	2	593	2	ZCWPW2	3	28520395	Nonsense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08		28520395	169502035	67	31903											
MLH1	4292	broad.mit.edu	37	chr3	37048514	37048514	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatggaaaactgaaagcccCtcctaaaccatgtgctggca	14	7	9	11	0	0	2	0	1	0	1	1	3	1	3	4	2	4	2	4	2	5	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:37048514C>G	uc003cgl.2	+	5	473	c.413C>G	c.(412-414)CCT>CGT	p.P138R	MLH1_uc011aye.1_5'UTR|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Missense_Mutation_p.P138R|MLH1_uc003cgn.3_5'UTR|MLH1_uc011ayc.1_Missense_Mutation_p.P40R|MLH1_uc011ayd.1_5'UTR|MLH1_uc003cgo.2_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	138					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						CTGAAAGCCCCTCCTAAACCA	0.373		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				14	19					0	0	0	0	G	37048514	G	G	37048514	3	3	170	1	0	0	0	0	1	0	0	0	9670	681	24	4	431	4	MLH1	3	37048514	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	8528119	37048514	160973916	68	31904											
SCN11A	11280	broad.mit.edu	37	chr3	38949584	38949584	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtttcaagggaagtaagtgaActtctgtcaattcccatggc	11	12	10	8	0	3	1	2	1	1	0	4	2	4	2	1	2	1	2	1	2	5	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:38949584A>C	uc011ays.1	-	10	1528	c.1329T>G	c.(1327-1329)AGT>AGG	p.S443R		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	443					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAGTAAGTGAACTTCTGTCAA	0.388													24	31					0	0	0	0	C	38949584	C	C	38949584	3	2	170	1	0	0	0	0	1	0	0	0	13978	40	2	5	4114	5	SCN11A	3	38949584	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	1901070	38949584	159072846	69	31905											
RBM6	10180	broad.mit.edu	37	chr3	50091779	50091779	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccttacagtgtaaggcaaaCattggtgggcaccgatcttc	10	11	10	10	1	1	0	0	0	1	0	3	1	2	0	2	3	2	3	2	3	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:50091779C>T	uc003cyc.2	+	8	1777	c.1644C>T	c.(1642-1644)AAC>AAT	p.N548N	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_Silent_p.N67N|RBM6_uc003cyd.2_Silent_p.N26N|RBM6_uc003cye.2_Silent_p.N26N|RBM6_uc011bdi.1_5'UTR|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	548					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		GTAAGGCAAACATTGGTGGGC	0.383													27	116					0	0	0	0	T	50091779	T	T	50091779	2	4	170	1	0	0	0	0	0	0	0	1	13209	477	17	4		4	RBM6	3	50091779	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	11142195	50091779	147930651	70	31906											
GXYLT2	727936	broad.mit.edu	37	chr3	73016867	73016867	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcactctatgaagcaatacgGgatgtaagtgtgcccttgct	10	11	11	9	1	1	1	0	1	1	0	1	2	1	2	1	1	4	4	1	1	5	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:73016867G>T	uc003dpg.2	+	6	1146	c.1146G>T	c.(1144-1146)CGG>CGT	p.R382R		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	382	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						AAGCAATACGGGATGTAAGTG	0.483													3	15					6.4e-05	7.00952e-05	1	0	T	73016867	T	T	73016867	2	4	170	1	0	0	0	0	0	0	0	1	6943	1219	43	4		4	GXYLT2	3	73016867	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	22925088	73016867	125005563	71	31907											
PDZRN3	23024	broad.mit.edu	37	chr3	73433279	73433279	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgcccacttcgggatctTccgtgatggagagcagattc	7	10	14	10	2	1	3	0	1	1	2	4	5	2	4	2	3	2	1	2	3	0	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:73433279T>G	uc003dpl.1	-	10	2534	c.2438A>C	c.(2437-2439)GAA>GCA	p.E813A	PDZRN3_uc011bgh.1_Missense_Mutation_p.E470A|PDZRN3_uc010hoe.1_Missense_Mutation_p.E511A|PDZRN3_uc011bgf.1_Missense_Mutation_p.E530A|PDZRN3_uc011bgg.1_Missense_Mutation_p.E533A	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	813							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TTCGGGATCTTCCGTGATGGA	0.652													17	49					0	0	0	0	G	73433279	G	G	73433279	3	3	170	1	0	0	0	0	1	0	0	0	11763	1783	62	5	766	5	PDZRN3	3	73433279	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	416412	73433279	124589151	72	31908											
CNTN3	5067	broad.mit.edu	37	chr3	74411124	74411124	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggtttacaatccaagctGaccaggctgcccacctgcac	9	8	9	15	0	0	1	0	1	0	0	1	1	1	1	4	2	4	4	4	2	3	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:74411124G>T	uc003dpm.1	-	10	1361	c.1281C>A	c.(1279-1281)GTC>GTA	p.V427V		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	427	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		AATCCAAGCTGACCAGGCTGC	0.502													7	30					5.18039e-06	5.77075e-06	1	0	T	74411124	T	T	74411124	2	4	170	1	0	0	0	0	0	0	0	1	3657	1277	45	2		2	CNTN3	3	74411124	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	977845	74411124	123611306	73	31909											
ROBO1	6091	broad.mit.edu	37	chr3	78766929	78766929	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttacctaagacagtcagctcGgctacttcactctcacgttc	9	12	6	14	2	3	1	3	0	1	1	6	1	3	1	1	1	3	3	1	1	3	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:78766929G>A	uc003dqe.2	-	6	970	c.762C>T	c.(760-762)GCC>GCT	p.A254A	ROBO1_uc003dqb.2_Silent_p.A215A|ROBO1_uc003dqc.2_Silent_p.A215A|ROBO1_uc003dqd.2_Silent_p.A215A|ROBO1_uc003dqf.1_5'Flank	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	254	Extracellular (Potential).|Ig-like C2-type 2.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CAGTCAGCTCGGCTACTTCAC	0.383													4	13					0	0	0	0	A	78766929	A	A	78766929	2	1	170	1	0	0	0	0	0	0	0	1	13578	1103	39	1		1	ROBO1	3	78766929	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	4355805	78766929	119255501	74	31910											
CADM2	253559	broad.mit.edu	37	chr3	85961535	85961535	+	Nonsense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttcagatgtaaaatattTaaaagaagaggatgcaaatc	19	12	7	3	0	1	3	1	0	0	3	2	4	1	4	0	1	1	2	0	1	7	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:85961535T>G	uc003dqj.2	+	5	1141	c.515T>G	c.(514-516)TTA>TGA	p.L172*	CADM2_uc003dqk.2_Nonsense_Mutation_p.L181*|CADM2_uc003dql.2_Nonsense_Mutation_p.L174*	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	172	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GTAAAATATTTAAAAGAAGAG	0.383													3	21					0	0	0	0	G	85961535	G	G	85961535	4	3	170	1	0	0	0	0	0	1	0	0	2579	1764	61	5	604	5	CADM2	3	85961535	Nonsense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	7194606	85961535	112060895	75	31911											
EPHA3	2042	broad.mit.edu	37	chr3	89156987	89156987	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccgcagccttccaatgaagGtaagccaggtaccgcgacgc	10	6	11	14	4	0	1	0	1	0	0	2	2	2	1	5	2	3	3	5	2	4	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:89156987G>C	uc003dqy.2	+	1	313	c.88_splice	c.e1+1	p.V30_splice	EPHA3_uc003dqx.1_Splice_Site_p.V30_splice|EPHA3_uc010hon.1_Splice_Site	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor							extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TCCAATGAAGGTAAGCCAGGT	0.597										TSP Lung(6;0.00050)			14	31					0	0	0	0	C	89156987	C	C	89156987	5	2	170	1	0	0	0	0	0	0	1	0	5192	1275	44	4	91	4	EPHA3	3	89156987	Splice_Site	SNP	G	TCGA-CV-5432-01A-02D-1683-08	3195452	89156987	108865443	76	31912											
TRAT1	50852	broad.mit.edu	37	chr3	108568076	108568076	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaaatctgtaaataagaTgcaggaagccaccccatctg	16	7	9	9	0	2	2	0	0	2	2	2	4	2	3	3	1	2	2	3	1	5	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:108568076T>A	uc003dxi.1	+	5	422	c.278T>A	c.(277-279)ATG>AAG	p.M93K	TRAT1_uc010hpx.1_Missense_Mutation_p.M56K	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	93	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						GTAAATAAGATGCAGGAAGCC	0.363													14	54					0	0	0	0	A	108568076	A	A	108568076	3	1	170	1	0	0	0	0	1	0	0	0	16533	1464	51	5	296	5	TRAT1	3	108568076	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	19411089	108568076	89454354	77	31913											
DPPA2	151871	broad.mit.edu	37	chr3	109026954	109026954	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccttaggctgaacagctcTtgcagcaattcttgcccatg	9	11	9	12	0	2	1	0	1	2	0	2	1	2	1	2	1	6	4	2	1	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:109026954T>C	uc003dxo.2	-	6	830	c.583A>G	c.(583-585)AGA>GGA	p.R195G		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	195						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						TGAACAGCTCTTGCAGCAATT	0.438													25	91					0	0	0	0	C	109026954	C	C	109026954	3	2	170	1	0	0	0	0	1	0	0	0	4756	1617	56	5	325	5	DPPA2	3	109026954	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	458878	109026954	88995476	78	31914											
SEMA5B	54437	broad.mit.edu	37	chr3	122646669	122646669	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggagttatattgggcagtgCgaagcggtggcccactgccc	7	9	15	10	2	0	0	0	0	0	0	0	2	0	1	2	4	3	2	2	4	3	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:122646669C>A	uc003efz.1	-	8	1122	c.818G>T	c.(817-819)CGC>CTC	p.R273L	SEMA5B_uc011bju.1_Missense_Mutation_p.R215L|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.R273L|SEMA5B_uc010hro.1_Missense_Mutation_p.R215L|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	273	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TTGGGCAGTGCGAAGCGGTGG	0.632													6	40					2.7689e-08	3.31082e-08	1	0	A	122646669	A	A	122646669	3	1	170	1	0	0	0	0	1	0	0	0	14103	768	27	3	2701	3	SEMA5B	3	122646669	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	13619715	122646669	75375761	79	31915											
KALRN	8997	broad.mit.edu	37	chr3	123987646	123987646	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggacccctcccagctgacGgaggagtttgatggctccct	6	9	13	13	1	0	2	0	2	0	0	2	5	2	5	4	4	1	3	4	4	0	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:123987646G>A	uc003ehg.2	+	5	634	c.507G>A	c.(505-507)ACG>ACA	p.T169T	KALRN_uc010hrv.1_Silent_p.T169T|KALRN_uc003ehf.1_Silent_p.T169T|KALRN_uc011bjy.1_Silent_p.T169T	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	169	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CCCAGCTGACGGAGGAGTTTG	0.587													13	59					0	0	0	0	A	123987646	A	A	123987646	2	1	170	1	0	0	0	0	0	0	0	1	8014	1103	39	1		1	KALRN	3	123987646	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1340977	123987646	74034784	80	31916											
AMOTL2	51421	broad.mit.edu	37	chr3	134089875	134089875	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgcctcccggggccccaCggggatctcggtcccccgca	4	5	13	19	4	1	0	0	0	1	0	4	2	3	1	6	5	1	1	6	5	0	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:134089875C>A	uc003eqf.2	-	2	692	c.575G>T	c.(574-576)CGT>CTT	p.R192L	AMOTL2_uc003eqg.1_Missense_Mutation_p.R134L|AMOTL2_uc003eqh.1_Missense_Mutation_p.R134L	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	134										large_intestine(1)	1						CGGGGCCCCACGGGGATCTCG	0.687													11	7					0.00010058	0.000108938	1	0	A	134089875	A	A	134089875	3	1	170	1	0	0	0	0	1	0	0	0	584	536	19	3	1977	3	AMOTL2	3	134089875	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	10102229	134089875	63932555	81	31917											
AGTR1	185	broad.mit.edu	37	chr3	148459551	148459551	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatatttttaagataattatGgcaattgtgcttttcttttt	10	22	6	3	0	1	1	0	0	1	1	1	2	1	1	0	1	1	2	0	1	5	11			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:148459551G>A	uc003ewg.2	+	4	1175	c.729G>A	c.(727-729)ATG>ATA	p.M243I	AGTR1_uc003ewh.2_Missense_Mutation_p.M243I|AGTR1_uc003ewi.2_Missense_Mutation_p.M243I|AGTR1_uc003ewj.2_Missense_Mutation_p.M243I|AGTR1_uc003ewk.2_Missense_Mutation_p.M243I	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	243	Helical; Name=6; (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	AGATAATTATGGCAATTGTGC	0.328													72	33					0	0	0	0	A	148459551	A	A	148459551	3	1	170	1	0	0	0	0	1	0	0	0	401	1348	47	4	731	4	AGTR1	3	148459551	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	14369676	148459551	49562879	82	31918											
P2RY1	5028	broad.mit.edu	37	chr3	152553781	152553781	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcggcttcctgggcaacagCgtggccatctggatgttcgt	6	11	13	11	3	1	0	0	0	1	0	4	1	2	1	2	4	2	3	2	4	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:152553781C>A	uc003ezq.2	+	1	1046	c.210C>A	c.(208-210)AGC>AGA	p.S70R		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	70	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TGGGCAACAGCGTGGCCATCT	0.537													6	121					0.00116845	0.00121506	1	0	A	152553781	A	A	152553781	3	1	170	1	0	0	0	0	1	0	0	0	11400	767	27	3	212	3	P2RY1	3	152553781	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	4094230	152553781	45468649	83	31919											
PLCH1	23007	broad.mit.edu	37	chr3	155199248	155199248	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctaacgactttgtcttcaCagtcacgcccttcttgtctc	6	15	5	15	2	6	0	2	0	4	0	7	1	6	0	1	0	1	0	1	0	1	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:155199248C>A	uc011bok.1	-	23	4868	c.4591G>T	c.(4591-4593)GTG>TTG	p.V1531L	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.V1493L	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1531					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TTTGTCTTCACAGTCACGCCC	0.443													13	73					0.000219431	0.000235708	1	0	A	155199248	A	A	155199248	3	1	170	1	0	0	0	0	1	0	0	0	12092	478	17	4	494	4	PLCH1	3	155199248	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	2645467	155199248	42823182	84	31920											
SPATA16	83893	broad.mit.edu	37	chr3	172674544	172674544	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttctattttatcagctcttAtttttgtcgcaaatggtgtg	7	21	7	6	1	3	0	1	0	2	0	4	0	3	0	0	1	1	2	0	1	4	7			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:172674544A>T	uc003fin.3	-	6	1162	c.1004T>A	c.(1003-1005)ATA>AAA	p.I335K		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	335					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			ATCAGCTCTTATTTTTGTCGC	0.368													5	57					0	0	0	0	T	172674544	T	T	172674544	3	4	170	1	0	0	0	0	1	0	0	0	15067	449	16	5	729	5	SPATA16	3	172674544	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	17475296	172674544	25347886	85	31921											
IL1RAP	3556	broad.mit.edu	37	chr3	190366326	190366326	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgaaggtgaaagagctgaaGagggctaagacggtgctcac	14	5	15	7	2	1	5	1	2	0	3	1	6	1	5	0	3	2	3	0	3	4	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:190366326G>T	uc003fsm.1	+	12	1751	c.1545G>T	c.(1543-1545)AAG>AAT	p.K515N	IL1RAP_uc010hzg.1_Missense_Mutation_p.K515N|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Missense_Mutation_p.K515N|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Intron	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	515	Cytoplasmic (Potential).|TIR.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		AAGAGCTGAAGAGGGCTAAGA	0.498													11	97					4.36969e-10	5.4068e-10	1	0	T	190366326	T	T	190366326	3	4	170	1	0	0	0	0	1	0	0	0	7699	933	33	2	1603	2	IL1RAP	3	190366326	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	17691782	190366326	7656104	86	31922											
OPA1	4976	broad.mit.edu	37	chr3	193366587	193366587	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatttatattgcctagaatGaactatttgaaaaagctaaa	17	14	6	4	0	0	3	0	2	0	1	0	3	0	3	1	0	3	2	1	0	11	9			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:193366587G>T	uc003ftm.2	+	19	2008	c.1774G>T	c.(1774-1776)GAA>TAA	p.E592*	OPA1_uc003ftg.2_Nonsense_Mutation_p.E647*|OPA1_uc003fth.2_Nonsense_Mutation_p.E611*|OPA1_uc003fti.2_Nonsense_Mutation_p.E629*|OPA1_uc003ftj.2_Nonsense_Mutation_p.E610*|OPA1_uc003ftk.2_Nonsense_Mutation_p.E593*|OPA1_uc003ftl.2_Nonsense_Mutation_p.E574*|OPA1_uc003ftn.2_Nonsense_Mutation_p.E556*	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	592	Mitochondrial intermembrane (By similarity).				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		TGCCTAGAATGAACTATTTGA	0.313													19	64					3.51602e-12	4.46351e-12	1	0	T	193366587	T	T	193366587	4	4	170	1	0	0	0	0	0	1	0	0	10925	1291	45	2	2021	2	OPA1	3	193366587	Nonsense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	3000261	193366587	4655843	87	31923											
FAM43A	131583	broad.mit.edu	37	chr3	194408726	194408726	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgacagcacgggcagcgagAgctccatcgagggcgggggc	8	2	19	12	5	0	1	0	0	0	1	2	4	1	1	1	4	3	3	1	4	0	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr3:194408726A>T	uc003fuj.2	+	1	2105	c.1171A>T	c.(1171-1173)AGC>TGC	p.S391C		NM_153690	NP_710157	Q8N2R8	FA43A_HUMAN	hypothetical protein LOC131583	391										central_nervous_system(1)	1	all_cancers(143;2.04e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.147)	OV - Ovarian serous cystadenocarcinoma(49;8.37e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.78e-05)		GGGCAGCGAGAGCTCCATCGA	0.736													7	15					0	0	0	0	T	194408726	T	T	194408726	3	4	170	1	0	0	0	0	1	0	0	0	5594	304	11	5	1173	5	FAM43A	3	194408726	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	1042139	194408726	3613704	88	31924											
C4orf50	389197	broad.mit.edu	37	chr4	5975389	5975389	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctctgggactctacctcTgggactcccggagccaggaa	8	8	11	14	1	3	0	0	0	3	0	5	4	4	4	3	4	2	0	3	4	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr4:5975389T>C	uc003git.1	-	4	495	c.405A>G	c.(403-405)CCA>CCG	p.P135P		NM_207405	NP_997288	Q6ZRC1	CD050_HUMAN	hypothetical protein LOC389197	135										pancreas(2)|breast(1)	3						ACTCTACCTCTGGGACTCCCG	0.637													73	53					0	0	0	0	C	5975389	C	C	5975389	2	2	170	1	0	0	0	0	0	0	0	1	2286	1567	55	5		5	C4orf50	4	5975389	Silent	SNP	T	TCGA-CV-5432-01A-02D-1683-08		5975389	185178887	89	31925											
SORCS2	57537	broad.mit.edu	37	chr4	7533275	7533275	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcatcagatttcgggacGtcctacaccaagctcaccct	10	9	8	14	2	3	1	3	0	0	1	5	2	4	2	3	2	2	1	3	2	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr4:7533275G>A	uc003gkb.3	+	3	567	c.567G>A	c.(565-567)ACG>ACA	p.T189T	SORCS2_uc011bwi.1_Silent_p.T17T	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	189	BNR 1.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						ATTTCGGGACGTCCTACACCA	0.602													13	10					0	0	0	0	A	7533275	A	A	7533275	2	1	170	1	0	0	0	0	0	0	0	1	14995	1132	40	1		1	SORCS2	4	7533275	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1557886	7533275	183621001	90	31926											
N4BP2	55728	broad.mit.edu	37	chr4	40104316	40104316	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaattctctgaagctcctgTagatttggatgccagtgaac	10	13	9	9	0	2	3	1	2	1	1	4	4	3	4	2	1	3	2	2	1	4	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr4:40104316T>C	uc003guy.3	+	4	1189	c.851T>C	c.(850-852)GTA>GCA	p.V284A	N4BP2_uc010ifq.2_Missense_Mutation_p.V204A|N4BP2_uc010ifr.2_Missense_Mutation_p.V204A	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	284						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GAAGCTCCTGTAGATTTGGAT	0.458													28	15					0	0	0	0	C	40104316	C	C	40104316	3	2	170	1	0	0	0	0	1	0	0	0	10163	1638	57	5	857	5	N4BP2	4	40104316	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	32571041	40104316	151049960	91	31927											
LPHN3	23284	broad.mit.edu	37	chr4	62679530	62679530	+	Missense_Mutation	SNP	A	C	C																															ttgttttgggtccacagggcAggcacatcatggacaagttt																										TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr4:62679530A>C	uc010ihh.2	+	6	1372	c.1199A>C	c.(1198-1200)CAG>CCG	p.Q400P	LPHN3_uc003hcq.3_Missense_Mutation_p.Q400P|LPHN3_uc003hcs.1_Missense_Mutation_p.Q229P	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	400	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						tccacagggcaggcacatcat	0.124													8	8					0	0	0	0	C	62679530	C	C	62679530	3	2	170	1	0	0	0	0	1	0	0	0	8967	188	7	5	1221	5	LPHN3	4	62679530	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	22575214	62679530	128474746	92	31928	62	2									
LPHN3	23284	broad.mit.edu	37	chr4	62679532	62679532	+	Missense_Mutation	SNP	G	T	T																															gttttgggtccacagggcagGcacatcatggacaagtttca																										TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr4:62679532G>T	uc010ihh.2	+	6	1374	c.1201G>T	c.(1201-1203)GCA>TCA	p.A401S	LPHN3_uc003hcq.3_Missense_Mutation_p.A401S|LPHN3_uc003hcs.1_Missense_Mutation_p.A230S	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	401	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						cacagggcaggcacatcatgg	0.119													8	8					4.68919e-08	5.55598e-08	1	0	T	62679532	T	T	62679532	3	4	170	1	0	0	0	0	1	0	0	0	8967	1203	42	4	1223	4	LPHN3	4	62679532	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	2	62679532	128474744	93	31929	62	2									
HERC3	8916	broad.mit.edu	37	chr4	89607922	89607922	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagattaccccggggaggAtgtggaggagactttctgcc	8	11	14	8	1	1	2	0	0	1	2	1	6	1	5	3	5	2	0	3	5	2	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr4:89607922A>G	uc003hrw.1	+	22	2709	c.2543A>G	c.(2542-2544)GAT>GGT	p.D848G	HERC3_uc011cdn.1_Missense_Mutation_p.D730G|HERC3_uc011cdo.1_Missense_Mutation_p.D292G	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	848					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		CCCGGGGAGGATGTGGAGGAG	0.423													14	17					0	0	0	0	G	89607922	G	G	89607922	3	3	170	1	0	0	0	0	1	0	0	0	7098	333	12	5	2621	5	HERC3	4	89607922	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	26928390	89607922	101546354	94	31930											
GRID2	2895	broad.mit.edu	37	chr4	94006249	94006249	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacgccatgcatatcccccaCctcttcattcagcgctcaac	9	9	5	18	2	4	0	3	0	1	0	5	1	5	0	4	0	3	2	4	0	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr4:94006249C>A	uc011cdt.1	+	3	606	c.348C>A	c.(346-348)CAC>CAA	p.H116Q	GRID2_uc010ikx.2_Missense_Mutation_p.H116Q|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	116	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATATCCCCCACCTCTTCATTC	0.562													21	19					5.35356e-11	6.68767e-11	1	0	A	94006249	A	A	94006249	3	1	170	1	0	0	0	0	1	0	0	0	6811	506	18	4	358	4	GRID2	4	94006249	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	4398327	94006249	97148027	95	31931											
NDST4	64579	broad.mit.edu	37	chr4	115858477	115858477	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctctctgtgctcaccatGatgctattgtgaatgaagcc	8	13	10	10	0	2	3	1	3	1	0	3	3	2	3	2	1	3	3	2	1	3	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr4:115858477G>T	uc003ibu.2	-	5	2083	c.1404C>A	c.(1402-1404)ATC>ATA	p.I468I	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	468	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TGCTCACCATGATGCTATTGT	0.448													36	11					4.62619e-21	6.41433e-21	1	0	T	115858477	T	T	115858477	2	4	170	1	0	0	0	0	0	0	0	1	10312	1280	45	2		2	NDST4	4	115858477	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	21852228	115858477	75295799	96	31932											
NR3C2	4306	broad.mit.edu	37	chr4	149356316	149356316	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcacttcttctagacgacAggtcgccgtgtgatttccat	8	13	8	12	3	3	2	1	1	2	1	5	3	4	2	2	1	0	0	2	1	1	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr4:149356316A>T	uc003ilj.3	-	2	2031	c.1697T>A	c.(1696-1698)CTG>CAG	p.L566Q	NR3C2_uc003ilk.3_Missense_Mutation_p.L566Q|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	566	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TCTAGACGACAGGTCGCCGTG	0.413													22	53					0	0	0	0	T	149356316	T	T	149356316	3	4	170	1	0	0	0	0	1	0	0	0	10685	188	7	5	1289	5	NR3C2	4	149356316	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	33497839	149356316	41797960	97	31933											
DNAH5	1767	broad.mit.edu	37	chr5	13859686	13859686	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtactgcacccatttttGaatctgggctttgaatggca	10	13	10	8	0	1	2	0	2	1	0	1	2	1	2	1	3	2	4	1	3	4	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr5:13859686G>A	uc003jfd.2	-	30	4867	c.4825C>T	c.(4825-4827)CAA>TAA	p.Q1609*		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1609	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACCCATTTTTGAATCTGGGCT	0.378									Kartagener_syndrome				42	124					0	0	0	0	A	13859686	A	A	13859686	4	1	170	1	0	0	0	0	0	1	0	0	4626	1299	45	2	9249	2	DNAH5	5	13859686	Nonsense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08		13859686	167055574	98	31934											
CDH18	1016	broad.mit.edu	37	chr5	19839081	19839081	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actggacagatgcaagatgtGctagtaattttcattgtaag	13	13	10	5	0	1	2	1	0	0	2	1	3	1	3	0	1	2	4	0	1	4	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr5:19839081G>A	uc003jgc.2	-	2	392	c.15C>T	c.(13-15)AGC>AGT	p.S5S	CDH18_uc003jgd.2_Silent_p.S5S|CDH18_uc011cnm.1_Silent_p.S5S	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	5					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TGCAAGATGTGCTAGTAATTT	0.433													16	12					0	0	0	0	A	19839081	A	A	19839081	2	1	170	1	0	0	0	0	0	0	0	1	3118	1310	46	4		4	CDH18	5	19839081	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	5979395	19839081	161076179	99	31935											
PRDM9	56979	broad.mit.edu	37	chr5	23522455	23522455	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaagatgtatagcctgcGagaaagaaagggtcatgcat	17	7	12	5	1	1	4	1	0	0	4	1	5	1	4	1	1	3	2	1	1	6	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr5:23522455G>T	uc003jgo.2	+	7	733	c.551G>T	c.(550-552)CGA>CTA	p.R184L		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	184					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TATAGCCTGCGAGAAAGAAAG	0.458										HNSCC(3;0.000094)			45	38					5.2432e-18	7.14318e-18	1	0	T	23522455	T	T	23522455	3	4	170	1	0	0	0	0	1	0	0	0	12525	1058	37	3	573	3	PRDM9	5	23522455	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	3683374	23522455	157392805	100	31936											
PRDM9	56979	broad.mit.edu	37	chr5	23527462	23527462	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtctgcagggagtgtgggcgGggctttcgcgataagtcaca	7	9	17	8	3	2	0	1	0	1	0	3	2	2	1	0	4	1	2	0	4	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr5:23527462G>T	uc003jgo.2	+	11	2447	c.2265G>T	c.(2263-2265)CGG>CGT	p.R755R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	755	C2H2-type 10.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGTGTGGGCGGGGCTTTCGCG	0.582										HNSCC(3;0.000094)			35	36					2.40579e-17	3.25489e-17	1	0	T	23527462	T	T	23527462	2	4	170	1	0	0	0	0	0	0	0	1	12525	1219	43	4		4	PRDM9	5	23527462	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	5007	23527462	157387798	101	31937											
CDH10	1008	broad.mit.edu	37	chr5	24488121	24488121	+	Frame_Shift_Del	DEL	C	-	-																															ctgcaggattcctcagggtgCcgatatcaaaggcctgggtg																										TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	d6ac7ee1-8970-4160-8cbe-c90ce8226214	g.chr5:24488121delC	uc003jgr.1	-	12	2350	c.2018delG	c.(2017-2019)GGCfs	p.G673fs	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	673	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		CCTCAGGGTGCCGATATCAAA	0.468										HNSCC(23;0.051)			---	---	---								-	24488121	-	-	24488121	7	5	170	1	0	1	0	1	0	0	0	0	3111	739	26	0	352	0	CDH10	5	24488121	Frame_Shift_Del	DEL	C	TCGA-CV-5432-01A-02D-1683-08	960659	24488121	156427139	102	31938											
ADAMTS12	81792	broad.mit.edu	37	chr5	33616118	33616118	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaagtttccagctccctCaatttccatcactcttatgt	9	14	5	13	0	3	0	2	0	1	0	6	1	6	1	3	1	1	2	3	1	3	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr5:33616118C>A	uc003jia.1	-	15	2366	c.2203G>T	c.(2203-2205)GAG>TAG	p.E735*	ADAMTS12_uc010iuq.1_Nonsense_Mutation_p.E650*	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	735	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CCAGCTCCCTCAATTTCCATC	0.448										HNSCC(64;0.19)			14	44					4.3838e-07	5.04137e-07	1	0	A	33616118	A	A	33616118	4	1	170	1	0	0	0	0	0	1	0	0	257	835	29	2	2621	2	ADAMTS12	5	33616118	Nonsense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	9127997	33616118	147299142	103	31939											
HEATR7B2	133558	broad.mit.edu	37	chr5	41052600	41052600	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgttgcaaactgggagaaGacataatcaatcaatggcca	17	7	9	8	1	2	2	2	0	0	2	2	3	2	2	1	2	3	2	1	2	6	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr5:41052600G>T	uc003jmj.3	-	12	1687	c.1197C>A	c.(1195-1197)GTC>GTA	p.V399V	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	399							binding			ovary(6)|central_nervous_system(2)	8						ACTGGGAGAAGACATAATCAA	0.403													13	51					7.93312e-07	9.04329e-07	1	0	T	41052600	T	T	41052600	2	4	170	1	0	0	0	0	0	0	0	1	7074	929	33	2		2	HEATR7B2	5	41052600	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	7436482	41052600	139862660	104	31940											
MEF2C	4208	broad.mit.edu	37	chr5	88047672	88047672	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttacatccttatgaggacatAcctgtgttacctgcacttgg	9	14	8	10	0	0	1	0	1	0	0	1	2	1	2	3	2	4	2	3	2	4	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr5:88047672A>T	uc003kjj.2	-	5	1262	c.589_splice	c.e5+1	p.G197_splice	MEF2C_uc003kji.2_Splice_Site_p.G197_splice|MEF2C_uc003kjk.2_Splice_Site_p.G197_splice|MEF2C_uc003kjm.2_Splice_Site_p.G195_splice|MEF2C_uc003kjl.2_Splice_Site_p.G215_splice	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1						apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		ATGAGGACATACCTGTGTTAC	0.453										HNSCC(66;0.2)			43	105					0	0	0	0	T	88047672	T	T	88047672	5	4	170	1	0	0	0	0	0	0	1	0	9510	405	14	5	858	5	MEF2C	5	88047672	Splice_Site	SNP	A	TCGA-CV-5432-01A-02D-1683-08	46995072	88047672	92867588	105	31941											
KCNN2	3781	broad.mit.edu	37	chr5	113698644	113698644	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagccgctgccgccgccgccGctgtttcgtcctcagccccc	2	7	10	22	6	1	0	1	0	0	0	3	0	2	0	8	0	3	3	8	0	0	1	rs34895620		TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr5:113698644G>T	uc003kqo.2	+	1	629	c.172G>T	c.(172-174)GCT>TCT	p.A58S		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	58	Poly-Ala.					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CGCCGCCGCCGCTGTTTCGTC	0.612													4	0					3.09899e-07	3.59556e-07	1	0	T	113698644	T	T	113698644	3	4	170	1	0	0	0	0	1	0	0	0	8118	1087	38	3	174	3	KCNN2	5	113698644	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	25650972	113698644	67216616	106	31942											
PCDHA2	56146	broad.mit.edu	37	chr5	140176015	140176015	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacgcgcaggagaacgcgcTggtgtcctactcgctggtgg	6	7	17	11	5	0	1	0	0	0	1	2	3	1	2	1	5	2	3	1	5	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr5:140176015T>A	uc003lhd.2	+	1	1572	c.1466T>A	c.(1465-1467)CTG>CAG	p.L489Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.L489Q|PCDHA2_uc011czy.1_Missense_Mutation_p.L489Q	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	489	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAACGCGCTGGTGTCCTAC	0.657													23	42					0	0	0	0	A	140176015	A	A	140176015	3	1	170	1	0	0	0	0	1	0	0	0	11578	1580	55	5	1468	5	PCDHA2	5	140176015	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	26477371	140176015	40739245	107	31943											
PCDHA13	56136	broad.mit.edu	37	chr5	140262396	140262396	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgattatttcactttggaCgcacaaaacagtcttgagca	14	11	7	9	2	2	1	1	1	1	0	2	3	2	2	0	1	3	2	0	1	4	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr5:140262396C>T	uc003lif.2	+	1	543	c.543C>T	c.(541-543)GAC>GAT	p.D181D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.D181D|PCDHA13_uc003lid.2_Silent_p.D181D	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	181	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCACTTTGGACGCACAAAACA	0.433													7	42					0	0	0	0	T	140262396	T	T	140262396	2	4	170	1	0	0	0	0	0	0	0	1	11577	535	19	1		1	PCDHA13	5	140262396	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	86381	140262396	40652864	108	31944											
FAM65B	9750	broad.mit.edu	37	chr6	24861201	24861201	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaacaaggaaaataatacCtttcatcttgatggagaatt	17	12	6	6	0	2	2	1	1	1	1	2	4	2	3	1	2	2	0	1	2	8	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr6:24861201C>A	uc003neo.1	-	8	804	c.628G>T	c.(628-630)GGT>TGT	p.G210C	FAM65B_uc011djs.1_Missense_Mutation_p.G239C|FAM65B_uc011dju.1_Missense_Mutation_p.G244C|FAM65B_uc003nep.2_Missense_Mutation_p.G210C|FAM65B_uc011djt.1_Missense_Mutation_p.G210C	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	210					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						AAAATAATACCTTTCATCTTG	0.428													6	3					0.00198382	0.00205749	1	0	A	24861201	A	A	24861201	3	1	170	1	0	0	0	0	1	0	0	0	5632	695	24	4	2652	4	FAM65B	6	24861201	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08		24861201	146253866	109	31945											
HIST1H4G	8369	broad.mit.edu	37	chr6	26246948	26246948	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtttgagcacgtagaccacGgccatggcggtgaccgtctt	7	9	13	12	5	1	3	0	2	1	1	1	3	1	3	3	3	1	3	3	3	1	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr6:26246948G>T	uc003nhf.2	-	1	258	c.258C>A	c.(256-258)GCC>GCA	p.A86A		NM_003547	NP_003538	Q99525	H4G_HUMAN	histone cluster 1, H4g	86					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				CGTAGACCACGGCCATGGCGG	0.567													19	8					4.35082e-09	5.28313e-09	1	0	T	26246948	T	T	26246948	2	4	170	1	0	0	0	0	0	0	0	1	7210	1103	39	3		3	HIST1H4G	6	26246948	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1385747	26246948	144868119	110	31946											
C4A	720	broad.mit.edu	37	chr6	31964316	31964316	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgacactgaccaaggcGcctgtggacctgctcggtgt	6	8	13	14	2	0	2	0	2	0	0	1	3	0	3	4	3	1	1	4	3	1	0	rs28357074		TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	d6ac7ee1-8970-4160-8cbe-c90ce8226214	g.chr6:31964316G>C	uc011doy.1	+	28	3666	c.3615G>C	c.(3613-3615)GCG>GCC	p.A1205A	C4A_uc011doz.1_Silent_p.A1205A	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	1205					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						TGACCAAGGCGCCTGTGGACC	0.617													41	14					0	0	0	0	C	31964316	C	C	31964316	2	2	170	1	0	0	0	0	0	0	0	1	2257	1074	38	3		3	C4A	6	31964316	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	5717368	31964316	139150751	111	31947											
DST	667	broad.mit.edu	37	chr6	56341031	56341031	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcagtaagtgtagtttcagcCcattgcaaccaagccagcaa	13	9	8	11	0	2	0	2	0	0	0	2	0	2	0	3	0	5	5	3	0	5	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr6:56341031C>A	uc003pdf.2	-	86	15451	c.15423G>T	c.(15421-15423)TGG>TGT	p.W5141C	DST_uc003pcz.3_Missense_Mutation_p.W4963C|DST_uc011dxj.1_Missense_Mutation_p.W4992C|DST_uc011dxk.1_Missense_Mutation_p.W5003C|DST_uc003pcy.3_Missense_Mutation_p.W4637C	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7049					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TAGTTTCAGCCCATTGCAACC	0.448													10	8					0.000442599	0.000466459	1	0	A	56341031	A	A	56341031	3	1	170	1	0	0	0	0	1	0	0	0	4805	624	22	4	1652	4	DST	6	56341031	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	24376715	56341031	114774036	112	31948											
PHF3	23469	broad.mit.edu	37	chr6	64395424	64395424	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attctttgagtgataagtcaCacgctcatcctggttgcttg	8	15	9	9	1	3	2	2	2	1	0	4	2	4	2	1	1	1	3	1	1	1	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr6:64395424C>A	uc003pep.1	+	3	1827	c.1801C>A	c.(1801-1803)CAC>AAC	p.H601N	PHF3_uc010kaf.1_Missense_Mutation_p.H601N|PHF3_uc003pem.2_Missense_Mutation_p.H554N|PHF3_uc010kag.1_Missense_Mutation_p.H513N|PHF3_uc010kah.1_Missense_Mutation_p.H415N|PHF3_uc003pen.2_Missense_Mutation_p.H513N|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.2_Missense_Mutation_p.H601N	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	601					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TGATAAGTCACACGCTCATCC	0.398													11	159					2.27111e-07	2.64287e-07	1	0	A	64395424	A	A	64395424	3	1	170	1	0	0	0	0	1	0	0	0	11891	478	17	4	1811	4	PHF3	6	64395424	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	8054393	64395424	106719643	113	31949											
SMAP1	60682	broad.mit.edu	37	chr6	71570005	71570005	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggtctggaagctcatcaGgtcagactctcagcacacaa	12	8	10	11	0	5	1	4	0	2	1	6	3	5	2	0	3	2	2	0	3	2	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr6:71570005G>T	uc003pfr.2	+	11	1620	c.1372G>T	c.(1372-1374)GGT>TGT	p.G458C	SMAP1_uc003pfs.2_Missense_Mutation_p.G431C|SMAP1_uc010kao.2_3'UTR|SMAP1_uc010kap.2_Missense_Mutation_p.G448C|B3GAT2_uc011dxz.1_RNA	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	stromal membrane-associated GTPase-activating	458					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding				0						AAGCTCATCAGGTCAGACTCT	0.498													8	60					0.000442599	0.000466459	1	0	T	71570005	T	T	71570005	3	4	170	1	0	0	0	0	1	0	0	0	14830	1000	35	4	1414	4	SMAP1	6	71570005	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	7174581	71570005	99545062	114	31950											
PHIP	55023	broad.mit.edu	37	chr6	79711634	79711634	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgaggaagttactcccaTctgagggatgagttgctcct	9	11	11	10	0	1	3	0	3	1	0	3	5	3	5	3	2	2	3	3	2	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr6:79711634T>A	uc003pir.2	-	17	2087	c.1861A>T	c.(1861-1863)ATG>TTG	p.M621L	PHIP_uc011dyp.1_Missense_Mutation_p.M621L	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	621					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		GTTACTCCCATCTGAGGGATG	0.398													22	13					0	0	0	0	A	79711634	A	A	79711634	3	1	170	1	0	0	0	0	1	0	0	0	11897	1435	50	5	3700	5	PHIP	6	79711634	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	8141629	79711634	91403433	115	31951											
AKIRIN2	55122	broad.mit.edu	37	chr6	88387536	88387536	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaataaacacacctcatacCtgcaagttttgtgttcaata	14	13	4	10	0	2	0	2	0	0	0	2	0	2	0	2	0	3	3	2	0	7	7			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr6:88387536C>A	uc003pmk.2	-	3	1112	c.529G>T	c.(529-531)GAA>TAA	p.E177*		NM_018064	NP_060534	Q53H80	AKIR2_HUMAN	akirin 2	177					innate immune response|transcription, DNA-dependent	transcriptional repressor complex					0						CACCTCATACCTGCAAGTTTT	0.378													18	29					3.51602e-12	4.46351e-12	1	0	A	88387536	A	A	88387536	4	1	170	1	0	0	0	0	0	1	0	0	462	695	24	4	94	4	AKIRIN2	6	88387536	Nonsense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	8675902	88387536	82727531	116	31952											
ASCC3	10973	broad.mit.edu	37	chr6	100964151	100964151	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcagttcaggaagggactCgatggaggtccgacccctag	10	7	14	10	2	2	0	2	0	0	0	4	6	3	3	3	4	0	1	3	4	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr6:100964151C>A	uc003pqk.2	-	39	6309	c.5980G>T	c.(5980-5982)GAG>TAG	p.E1994*		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1994					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GGAAGGGACTCGATGGAGGTC	0.453													43	33					5.44703e-19	7.44681e-19	1	0	A	100964151	A	A	100964151	4	1	170	1	0	0	0	0	0	1	0	0	1035	893	31	3	644	3	ASCC3	6	100964151	Nonsense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	12576615	100964151	70150916	117	31953											
LPA	4018	broad.mit.edu	37	chr6	160978515	160978515	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcattgtgtcagattgcAgtactcccacctcacacacg	10	10	8	13	1	2	2	2	1	0	1	3	2	3	2	2	0	3	3	2	0	1	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr6:160978515A>G	uc003qtl.2	-	30	4840	c.4720T>C	c.(4720-4722)TGC>CGC	p.C1574R		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4082	Kringle 36.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GTCAGATTGCAGTACTCCCAC	0.493													39	34					0	0	0	0	G	160978515	G	G	160978515	3	3	170	1	0	0	0	0	1	0	0	0	8953	188	7	5	1446	5	LPA	6	160978515	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	60014364	160978515	10136552	118	31954											
C7orf50	84310	broad.mit.edu	37	chr7	1040142	1040142	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtgcagcaggagccacgtCtgcctcgtcttctgaaacct	8	10	10	13	2	3	1	0	1	3	0	4	2	3	2	3	1	5	2	3	1	1	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:1040142C>T	uc003sju.2	-	4	439	c.369G>A	c.(367-369)CAG>CAA	p.Q123Q	C7orf50_uc003sjs.2_RNA|C7orf50_uc011jvt.1_Silent_p.Q123Q|C7orf50_uc011jvu.1_Silent_p.Q123Q	NM_032350	NP_115726	Q9BRJ6	CG050_HUMAN	hypothetical protein LOC84310	123							protein binding				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		GGAGCCACGTCTGCCTCGTCT	0.597													6	3					0	0	0	0	T	1040142	T	T	1040142	2	4	170	1	0	0	0	0	0	0	0	1	2410	912	32	2		2	C7orf50	7	1040142	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08		1040142	158098521	119	31955											
ITGB8	3696	broad.mit.edu	37	chr7	20403258	20403258	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgttttctccttcattgcAgaagacaatagatgtgcatc	11	14	7	9	0	2	3	1	0	1	3	4	3	2	3	1	0	2	3	1	0	3	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:20403258A>T	uc003suu.2	+	2	833	c.128_splice	c.e2-2	p.E43_splice	ITGB8_uc011jyh.1_Splice_Site|ITGB8_uc003sut.2_Splice_Site_p.E43_splice	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor						cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						CCTTCATTGCAGAAGACAATA	0.333													12	5					0	0	0	0	T	20403258	T	T	20403258	5	4	170	1	0	0	0	0	0	0	1	0	7940	202	7	5	132	5	ITGB8	7	20403258	Splice_Site	SNP	A	TCGA-CV-5432-01A-02D-1683-08	19363116	20403258	138735405	120	31956											
AVL9	23080	broad.mit.edu	37	chr7	32598671	32598671	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatccactgctgatgtttcAcataccaacttgggaactat	11	12	7	11	0	1	1	1	1	0	0	2	2	2	2	2	1	4	3	2	1	4	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:32598671A>T	uc003tcv.1	+	10	956	c.810A>T	c.(808-810)TCA>TCT	p.S270S	AVL9_uc011kai.1_Silent_p.S270S|AVL9_uc010kwj.1_Silent_p.S111S	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	270						integral to membrane					0						CTGATGTTTCACATACCAACT	0.463													18	31					0	0	0	0	T	32598671	T	T	32598671	2	4	170	1	0	0	0	0	0	0	0	1	1230	146	6	5		5	AVL9	7	32598671	Silent	SNP	A	TCGA-CV-5432-01A-02D-1683-08	12195413	32598671	126539992	121	31957											
SUN3	256979	broad.mit.edu	37	chr7	48035729	48035729	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actttctgaggtcccagcttCaatgatggaggctcctaaaa	11	11	9	10	0	2	2	1	2	1	0	4	3	4	3	2	3	1	2	2	3	3	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:48035729C>G	uc003tof.2	-	8	689	c.592G>C	c.(592-594)GAA>CAA	p.E198Q	SUN3_uc010kyq.2_Missense_Mutation_p.E98Q|SUN3_uc003tog.2_Missense_Mutation_p.E198Q|SUN3_uc011kcf.1_Missense_Mutation_p.E186Q	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	198	SUN.					integral to membrane				central_nervous_system(1)	1						GTCCCAGCTTCAATGATGGAG	0.303													14	78					0	0	0	0	G	48035729	G	G	48035729	3	3	170	1	0	0	0	0	1	0	0	0	15459	835	29	2	497	2	SUN3	7	48035729	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	15437058	48035729	111102934	122	31958											
AUTS2	26053	broad.mit.edu	37	chr7	70255697	70255697	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaagactacgagcacacGcggctccactccgtgcaccc	11	4	10	16	4	0	2	0	0	0	2	2	4	2	2	3	1	3	3	3	1	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:70255697G>A	uc003tvw.3	+	19	4238	c.3495G>A	c.(3493-3495)ACG>ACA	p.T1165T	AUTS2_uc003tvx.3_Silent_p.T1141T|AUTS2_uc011keg.1_Silent_p.T617T	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1165	His-rich.									ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		ACGAGCACACGCGGCTCCACT	0.672													14	29					0	0	0	0	A	70255697	A	A	70255697	2	1	170	1	0	0	0	0	0	0	0	1	1227	1074	38	1		1	AUTS2	7	70255697	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	22219968	70255697	88882966	123	31959											
HGF	3082	broad.mit.edu	37	chr7	81335729	81335729	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaattccaagccaagcttcaTaatctttcaagtctctgttt	11	15	5	10	0	4	0	2	0	2	0	6	1	5	0	2	0	2	2	2	0	5	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:81335729T>A	uc003uhl.2	-	15	1796	c.1631A>T	c.(1630-1632)TAT>TTT	p.Y544F	HGF_uc003uhm.2_Missense_Mutation_p.Y539F	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	544	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						CCAAGCTTCATAATCTTTCAA	0.338													26	76					0	0	0	0	A	81335729	A	A	81335729	3	1	170	1	0	0	0	0	1	0	0	0	7124	1406	49	5	571	5	HGF	7	81335729	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	11080032	81335729	77802934	124	31960											
PCLO	27445	broad.mit.edu	37	chr7	82580192	82580192	+	Frame_Shift_Del	DEL	C	-	-																															cctttgaatttcctgacgttCccactccaattcctcagcaa																										TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:82580192delC	uc003uhx.2	-	6	10001	c.9712delG	c.(9712-9714)GAAfs	p.E3238fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.E3238fs|PCLO_uc010lec.2_Frame_Shift_Del_p.E203fs	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3169	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCCTGACGTTCCCACTCCAAT	0.458													---	---	---								-	82580192	-	-	82580192	7	5	170	1	0	1	0	1	0	0	0	0	11637	864	30	0	5813	0	PCLO	7	82580192	Frame_Shift_Del	DEL	C	TCGA-CV-5432-01A-02D-1683-08	1244463	82580192	76558471	125	31961											
CALCR	799	broad.mit.edu	37	chr7	93108690	93108690	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccttggtatgcgggtaactGctgcattcggtcatagcatt	7	14	11	9	2	1	0	1	0	0	0	3	0	2	0	1	3	5	5	1	3	3	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:93108690G>A	uc003umv.1	-	4	496	c.235C>T	c.(235-237)CAG>TAG	p.Q79*	CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Nonsense_Mutation_p.Q61*|CALCR_uc003umw.2_Nonsense_Mutation_p.Q61*	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	61	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GCGGGTAACTGCTGCATTCGG	0.378													64	149					0	0	0	0	A	93108690	A	A	93108690	4	1	170	1	0	0	0	0	0	1	0	0	2591	1328	46	4	1339	4	CALCR	7	93108690	Nonsense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	10528498	93108690	66029973	126	31962											
MUC17	140453	broad.mit.edu	37	chr7	100681637	100681637	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acactcctttcactacttctActgaagccagttcacctcct	9	13	3	16	0	3	1	2	1	1	0	5	1	5	1	4	0	3	1	4	0	3	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:100681637A>G	uc003uxp.1	+	3	6993	c.6940A>G	c.(6940-6942)ACT>GCT	p.T2314A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2314	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|37.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACTACTTCTACTGAAGCCAG	0.483													115	143					0	0	0	0	G	100681637	G	G	100681637	3	3	170	1	0	0	0	0	1	0	0	0	10027	391	14	5	6950	5	MUC17	7	100681637	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	7572947	100681637	58457026	127	31963											
KCND2	3751	broad.mit.edu	37	chr7	119915648	119915648	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtacacactgaagagttgtgCctcagaattgggcttcttgc	9	12	11	9	0	2	3	1	1	1	2	2	3	2	3	1	1	3	3	1	1	3	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:119915648C>G	uc003vjj.1	+	1	1927	c.962C>G	c.(961-963)GCC>GGC	p.A321G		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	321	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					AAGAGTTGTGCCTCAGAATTG	0.512													23	35					0	0	0	0	G	119915648	G	G	119915648	3	3	170	1	0	0	0	0	1	0	0	0	8058	739	26	4	964	4	KCND2	7	119915648	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	19234011	119915648	39223015	128	31964											
PTPRZ1	5803	broad.mit.edu	37	chr7	121671535	121671535	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttattcacgtagatgatgtCggagcaattccaataaagca	14	12	8	7	2	1	2	1	1	0	1	3	3	2	3	1	1	2	3	1	1	6	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:121671535C>T	uc003vjy.2	+	15	5483	c.5088C>T	c.(5086-5088)GTC>GTT	p.V1696V	PTPRZ1_uc003vjz.2_Silent_p.V836V|PTPRZ1_uc011knt.1_Silent_p.V286V	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1696	Cytoplasmic (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TAGATGATGTCGGAGCAATTC	0.313													21	35					0	0	0	0	T	121671535	T	T	121671535	2	4	170	1	0	0	0	0	0	0	0	1	12879	871	31	1		1	PTPRZ1	7	121671535	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	1755887	121671535	37467128	129	31965											
GPR37	2861	broad.mit.edu	37	chr7	124387345	124387345	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgttggtggcagcacggaagCggtctatgcacagagcacat	10	7	14	10	3	1	1	0	0	1	1	1	2	1	2	0	4	4	5	0	4	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:124387345C>T	uc003vli.2	-	2	1727	c.1076G>A	c.(1075-1077)CGC>CAC	p.R359H		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	359	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						AGCACGGAAGCGGTCTATGCA	0.488													6	38					0	0	0	0	T	124387345	T	T	124387345	3	4	170	1	0	0	0	0	1	0	0	0	6729	768	27	1	769	1	GPR37	7	124387345	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	2715810	124387345	34751318	130	31966											
ZYX	7791	broad.mit.edu	37	chr7	143079743	143079743	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actctctgtcctcactgctgGatgacatgaccaagaatgat	11	11	8	11	0	2	4	1	3	1	1	4	5	3	5	2	1	1	1	2	1	2	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:143079743G>A	uc003wcw.2	+	4	621	c.466G>A	c.(466-468)GAT>AAT	p.D156N	ZYX_uc011ktd.1_5'UTR|ZYX_uc003wcx.2_Missense_Mutation_p.D156N|ZYX_uc011kte.1_Intron|ZYX_uc011ktf.1_5'UTR	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	156					cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					CTCACTGCTGGATGACATGAC	0.527													104	147					0	0	0	0	A	143079743	A	A	143079743	3	1	170	1	0	0	0	0	1	0	0	0	18321	1174	41	2	476	2	ZYX	7	143079743	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	18692398	143079743	16058920	131	31967											
OR2A2	442361	broad.mit.edu	37	chr7	143806846	143806846	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gactctaagcttcacacaccCatgtacttcttcctctcaca	10	12	3	16	0	4	0	2	0	3	0	6	1	5	0	2	0	2	2	2	0	2	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:143806846C>A	uc011ktz.1	+	1	171	c.171C>A	c.(169-171)CCC>CCA	p.P57P		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					TTCACACACCCATGTACTTCT	0.468													104	130					4.98208e-43	7.24161e-43	1	0	A	143806846	A	A	143806846	2	1	170	1	0	0	0	0	0	0	0	1	11031	581	21	4		4	OR2A2	7	143806846	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	727103	143806846	15331817	132	31968											
MLL3	58508	broad.mit.edu	37	chr7	151945277	151945277	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatgaaacatctttcacacAaccctcaattgtaggagtca	14	11	6	10	0	4	1	3	1	1	0	4	2	4	2	1	1	2	2	1	1	5	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr7:151945277A>C	uc003wla.2	-	14	2461	c.2242T>G	c.(2242-2244)TGT>GGT	p.C748G		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	748					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCTTTCACACAACCCTCAATT	0.378			N		medulloblastoma								4	186					0	0	0	0	C	151945277	C	C	151945277	3	2	170	1	0	0	0	0	1	0	0	0	9675	130	5	5	12677	5	MLL3	7	151945277	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	8138431	151945277	7193386	133	31969											
MYOM2	9172	broad.mit.edu	37	chr8	2056622	2056622	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caatgaaataaagaaccccaGtaagtaagcctccagccctt	16	7	6	12	0	0	2	0	1	0	1	1	2	1	2	5	0	3	2	5	0	7	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:2056622G>A	uc003wpx.3	+	24	3181	c.3043_splice	c.e24+1	p.T1015_splice	MYOM2_uc011kwi.1_Splice_Site_p.T440_splice	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2						muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AAGAACCCCAGTAAGTAAGCC	0.473													19	36					0	0	0	0	A	2056622	A	A	2056622	5	1	170	1	0	0	0	0	0	0	1	0	10145	1043	36	4	3134	4	MYOM2	8	2056622	Splice_Site	SNP	G	TCGA-CV-5432-01A-02D-1683-08		2056622	144307400	134	31970											
MFHAS1	9258	broad.mit.edu	37	chr8	8750004	8750004	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggcagtgagctggttgtgatCcacgtccagggtgcgcaggc	6	8	17	10	2	0	2	0	2	0	0	2	2	2	2	2	4	2	4	2	4	0	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	d6ac7ee1-8970-4160-8cbe-c90ce8226214	g.chr8:8750004C>G	uc003wsj.1	-	1	1128	c.565G>C	c.(565-567)GAT>CAT	p.D189H		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	189	LRR 6.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		TGGTTGTGATCCACGTCCAGG	0.677													6	7					0	0	0	0	G	8750004	G	G	8750004	3	3	170	1	0	0	0	0	1	0	0	0	9574	855	30	2	2605	2	MFHAS1	8	8750004	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	6693382	8750004	137614018	135	31971											
XPO7	23039	broad.mit.edu	37	chr8	21848388	21848388	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagacatgcggtgtcggactAccttctacacagcacttggg	9	9	11	12	2	1	1	0	0	1	1	2	2	1	2	1	3	4	1	1	3	2	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:21848388A>G	uc003xaa.3	+	18	2101	c.1999A>G	c.(1999-2001)ACC>GCC	p.T667A	XPO7_uc010lti.2_Missense_Mutation_p.T676A|XPO7_uc010ltk.2_Missense_Mutation_p.T668A	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	667					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		GTGTCGGACTACCTTCTACAC	0.403													34	118					0	0	0	0	G	21848388	G	G	21848388	3	3	170	1	0	0	0	0	1	0	0	0	17517	391	14	5	2121	5	XPO7	8	21848388	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	13098384	21848388	124515634	136	31972											
PNMA2	10687	broad.mit.edu	37	chr8	26365820	26365820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggggctgaggcgcatgtGccattgcctgtcccaacaaa	9	7	13	12	1	0	1	0	1	0	0	1	1	1	1	3	3	3	3	3	3	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:26365820G>A	uc003xez.2	-	3	1222	c.452C>T	c.(451-453)GCA>GTA	p.A151V		NM_007257	NP_009188	Q9UL42	PNMA2_HUMAN	paraneoplastic antigen MA2	151					apoptosis	nucleolus	protein binding				0		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		aggcgcatgtgccattgcctg	0													10	36					0	0	0	0	A	26365820	A	A	26365820	3	1	170	1	0	0	0	0	1	0	0	0	12209	1319	46	4	646	4	PNMA2	8	26365820	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	4517432	26365820	119998202	137	31973											
HOOK3	84376	broad.mit.edu	37	chr8	42823227	42823227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaagaagctagaagaccttgGtgatttaaggcggcaggtta	14	9	13	5	1	0	4	0	1	0	3	0	4	0	4	1	4	1	3	1	4	6	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:42823227G>A	uc003xpr.2	+	11	1234	c.992G>A	c.(991-993)GGT>GAT	p.G331D	HOOK3_uc010lxq.1_Missense_Mutation_p.G331D	NM_032410	NP_115786	Q86VS8	HOOK3_HUMAN	golgi-associated microtubule-binding protein	331	Potential.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			ovary(1)|breast(1)	2	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			GAAGACCTTGGTGATTTAAGG	0.358			T	RET	papillary thyroid								19	40					0	0	0	0	A	42823227	A	A	42823227	3	1	170	1	0	0	0	0	1	0	0	0	7323	1261	44	4	1034	4	HOOK3	8	42823227	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	16457407	42823227	103540795	138	31974											
PRKDC	5591	broad.mit.edu	37	chr8	48715931	48715931	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagccctgggaccggctccgGcagtggctcaggcggcagta	6	5	16	14	3	1	0	1	0	0	0	2	1	2	1	3	6	1	5	3	6	1	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:48715931G>A	uc003xqi.2	-	71	9915	c.9858C>T	c.(9856-9858)TGC>TGT	p.C3286C	PRKDC_uc003xqj.2_Silent_p.C3286C|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3286	FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACCGGCTCCGGCAGTGGCTCA	0.512								NHEJ					28	79					0	0	0	0	A	48715931	A	A	48715931	2	1	170	1	0	0	0	0	0	0	0	1	12583	1195	42	4		4	PRKDC	8	48715931	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	5892704	48715931	97648091	139	31975											
VCPIP1	80124	broad.mit.edu	37	chr8	67578251	67578251	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggctgaataatcaccagAgcttctcatgccactgaggg	10	9	12	10	0	2	3	2	2	1	1	3	3	2	3	2	3	2	2	2	3	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:67578251A>T	uc003xwn.2	-	1	1202	c.943T>A	c.(943-945)TCT>ACT	p.S315T	SGK3_uc003xwp.2_5'Flank|C8orf44_uc003xwo.1_5'Flank	NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	315	OTU.				protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TAATCACCAGAGCTTCTCATG	0.468													32	54					0	0	0	0	T	67578251	T	T	67578251	3	4	170	1	0	0	0	0	1	0	0	0	17209	304	11	5	2737	5	VCPIP1	8	67578251	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	18862320	67578251	78785771	140	31976											
ARFGEF1	10565	broad.mit.edu	37	chr8	68184095	68184095	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aataaacatctcatttgtccTgaaaataggtcctgcattct	13	14	5	9	0	2	1	1	1	2	0	5	1	4	1	2	1	2	1	2	1	6	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:68184095T>A	uc003xxo.1	-	10	1804	c.1414A>T	c.(1414-1416)AGG>TGG	p.R472W		NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	472					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TCATTTGTCCTGAAAATAGGT	0.358													8	41					0	0	0	0	A	68184095	A	A	68184095	3	1	170	1	0	0	0	0	1	0	0	0	852	1579	55	5	4255	5	ARFGEF1	8	68184095	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	605844	68184095	78179927	141	31977											
C8orf34	116328	broad.mit.edu	37	chr8	69552738	69552738	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acactgaacatctgttcaagGtgtgccaggtaaaagacata	15	9	9	8	0	2	2	1	1	1	1	2	2	2	2	1	2	2	2	1	2	5	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:69552738G>T	uc010lyz.2	+	8	1024	c.975G>T	c.(973-975)AGG>AGT	p.R325S	C8orf34_uc003xyb.2_Missense_Mutation_p.R300S	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	325					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			TCTGTTCAAGGTGTGCCAGGT	0.388													24	45					7.87624e-14	1.02997e-13	1	0	T	69552738	T	T	69552738	3	4	170	1	0	0	0	0	1	0	0	0	2434	1252	44	4	926	4	C8orf34	8	69552738	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1368643	69552738	76811284	142	31978											
KCNB2	9312	broad.mit.edu	37	chr8	73848742	73848742	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatgaccactgttggctaTggtgacatttaccctaaaac	12	11	7	11	0	0	2	0	2	0	0	0	2	0	2	3	2	2	2	3	2	4	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:73848742T>C	uc003xzb.2	+	3	1740	c.1152T>C	c.(1150-1152)TAT>TAC	p.Y384Y		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	384	Selectivity filter (By similarity).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CTGTTGGCTATGGTGACATTT	0.453													23	101					0	0	0	0	C	73848742	C	C	73848742	2	2	170	1	0	0	0	0	0	0	0	1	8052	1471	51	5		5	KCNB2	8	73848742	Silent	SNP	T	TCGA-CV-5432-01A-02D-1683-08	4296004	73848742	72515280	143	31979											
ZFHX4	79776	broad.mit.edu	37	chr8	77764235	77764235	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaccacagtcaccagcacAaattcagatgcaactacagc	15	5	5	16	0	2	1	2	0	0	1	2	1	2	1	3	0	5	2	3	0	3	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:77764235A>T	uc003yav.2	+	10	5330	c.4943A>T	c.(4942-4944)CAA>CTA	p.Q1648L	ZFHX4_uc003yau.1_Missense_Mutation_p.Q1693L|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q1648L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1648	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCACCAGCACAAATTCAGATG	0.423										HNSCC(33;0.089)			17	55					0	0	0	0	T	77764235	T	T	77764235	3	4	170	1	0	0	0	0	1	0	0	0	17702	130	5	5	5112	5	ZFHX4	8	77764235	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	3915493	77764235	68599787	144	31980											
SLC26A7	115111	broad.mit.edu	37	chr8	92365165	92365165	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttattgttgtgggactgaagGgaatgctaatacagttccga	11	13	12	5	1	0	1	0	1	0	0	1	4	1	3	1	2	2	3	1	2	5	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:92365165G>T	uc003yex.2	+	12	1533	c.1255G>T	c.(1255-1257)GGA>TGA	p.G419*	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Nonsense_Mutation_p.G419*|SLC26A7_uc003yfa.2_Nonsense_Mutation_p.G419*	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	419	Helical; (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			GGGACTGAAGGGAATGCTAAT	0.313													34	61					2.19962e-31	3.16196e-31	1	0	T	92365165	T	T	92365165	4	4	170	1	0	0	0	0	0	1	0	0	14586	1233	43	4	1293	4	SLC26A7	8	92365165	Nonsense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	14600930	92365165	53998857	145	31981											
TP53INP1	94241	broad.mit.edu	37	chr8	95952351	95952351	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaagcactcaagagatgcCggtaaacaggaaaagactga	17	4	11	9	1	1	3	1	1	0	2	1	5	1	4	2	2	3	2	2	2	6	1	rs141483665		TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:95952351C>T	uc003yhg.2	-	3	594	c.210G>A	c.(208-210)CCG>CCA	p.P70P	C8orf38_uc003yhe.1_Intron|C8orf38_uc003yhf.2_Intron|TP53INP1_uc003yhh.2_Silent_p.P70P	NM_033285	NP_150601	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	70					apoptosis	PML body					0	Breast(36;8.75e-07)					CAAGAGATGCCGGTAAACAGG	0.473													20	20					0	0	0	0	T	95952351	T	T	95952351	2	4	170	1	0	0	0	0	0	0	0	1	16455	639	23	1		1	TP53INP1	8	95952351	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	3587186	95952351	50411671	146	31982											
LRP12	29967	broad.mit.edu	37	chr8	105510273	105510273	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattaccacaacgaaactgAtcacaagcacaatttggttc	15	9	5	12	1	1	1	1	1	0	0	2	2	1	1	2	1	4	2	2	1	5	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:105510273A>T	uc003yma.2	-	5	602	c.507T>A	c.(505-507)GAT>GAA	p.D169E	LRP12_uc003ymb.2_Missense_Mutation_p.D150E|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	169	Extracellular (Potential).|LDL-receptor class A 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AACGAAACTGATCACAAGCAC	0.363													27	45					0	0	0	0	T	105510273	T	T	105510273	3	4	170	1	0	0	0	0	1	0	0	0	9004	330	12	5	2084	5	LRP12	8	105510273	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	9557922	105510273	40853749	147	31983											
PKHD1L1	93035	broad.mit.edu	37	chr8	110431467	110431467	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagtgtacattggacacacAtctacaatctcaacattgga	14	11	7	9	0	2	0	1	0	2	0	3	2	2	2	0	2	3	2	0	2	5	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:110431467A>T	uc003yne.2	+	22	2606	c.2502A>T	c.(2500-2502)ACA>ACT	p.T834T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	834	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTGGACACACATCTACAATCT	0.328										HNSCC(38;0.096)			3	22					0	0	0	0	T	110431467	T	T	110431467	2	4	170	1	0	0	0	0	0	0	0	1	12027	204	8	5		5	PKHD1L1	8	110431467	Silent	SNP	A	TCGA-CV-5432-01A-02D-1683-08	4921194	110431467	35932555	148	31984											
COL22A1	169044	broad.mit.edu	37	chr8	139649040	139649040	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacgttctccttgacttcccTtgaaaggaaaaaaaagaaaa	17	9	6	9	1	1	3	0	2	1	1	3	4	2	4	2	1	0	1	2	1	7	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:139649040T>G	uc003yvd.2	-	48	3949	c.3502_splice	c.e48-1	p.G1168_splice	COL22A1_uc011ljo.1_Splice_Site_p.G448_splice	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTGACTTCCCTTGAAAGGAAA	0.318										HNSCC(7;0.00092)			58	132					0	0	0	0	G	139649040	G	G	139649040	5	3	170	1	0	0	0	0	0	0	1	0	3696	1623	56	5	1452	5	COL22A1	8	139649040	Splice_Site	SNP	T	TCGA-CV-5432-01A-02D-1683-08	29217573	139649040	6714982	149	31985											
EPPK1	83481	broad.mit.edu	37	chr8	144940192	144940192	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaaagaaataggagcccCgtctcagggtccagggtggc	12	5	15	9	1	1	2	1	0	1	2	3	4	2	3	3	4	1	0	3	4	3	1	rs6982684		TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:144940192C>G	uc003zaa.1	-	2	15253	c.15240G>C	c.(15238-15240)ACG>ACC	p.T5080T		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5080	Plectin 65.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ATAGGAGCCCCGTCTCAGGGT	0.572													5	26					0	0	0	0	G	144940192	G	G	144940192	2	3	170	1	0	0	0	0	0	0	0	1	5214	639	23	3		3	EPPK1	8	144940192	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	5291152	144940192	1423830	150	31986											
PLEC	5339	broad.mit.edu	37	chr8	144995520	144995520	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggccacgtccacgggcacGcggtggctgtgcacggggtc	5	6	17	13	5	0	0	0	0	0	0	2	0	1	0	2	6	1	3	2	6	1	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr8:144995520G>A	uc003zaf.1	-	32	9050	c.8880C>T	c.(8878-8880)CGC>CGT	p.R2960R	PLEC_uc003zab.1_Silent_p.R2823R|PLEC_uc003zac.1_Silent_p.R2827R|PLEC_uc003zad.2_Silent_p.R2823R|PLEC_uc003zae.1_Silent_p.R2791R|PLEC_uc003zag.1_Silent_p.R2801R|PLEC_uc003zah.2_Silent_p.R2809R|PLEC_uc003zaj.2_Silent_p.R2850R	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2960	Plectin 4.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCACGGGCACGCGGTGGCTGT	0.682													12	101					0	0	0	0	A	144995520	A	A	144995520	2	1	170	1	0	0	0	0	0	0	0	1	12107	1074	38	1		1	PLEC	8	144995520	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	55328	144995520	1368502	151	31987											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			3	5					0	0	0	0	A	21971120	A	A	21971120	4	1	170	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08		21971120	119242311	152	31988											
RGP1	9827	broad.mit.edu	37	chr9	35750932	35750932	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccattggctgccagcgtGtcaactcccctatcacttta	8	12	7	14	1	2	1	2	1	0	0	3	1	3	1	4	1	3	1	4	1	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:35750932G>T	uc011lpf.1	+	5	574	c.433G>T	c.(433-435)GTC>TTC	p.V145F	GBA2_uc011lpb.1_5'Flank|GBA2_uc003zxw.2_5'Flank|GBA2_uc011lpc.1_5'Flank|GBA2_uc011lpd.1_5'Flank|RGP1_uc011lpe.1_Missense_Mutation_p.V185F	NM_001080496	NP_001073965	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog	145										ovary(1)	1	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTGCCAGCGTGTCAACTCCCC	0.562													58	18					1.08141e-31	1.56026e-31	1	0	T	35750932	T	T	35750932	3	4	170	1	0	0	0	0	1	0	0	0	13349	1377	48	4	575	4	RGP1	9	35750932	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	13779812	35750932	105462499	153	31989											
ROR2	4920	broad.mit.edu	37	chr9	94499675	94499675	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtctgcagctcctacctGtgattcggttttcaatctcc	7	14	8	12	1	3	1	1	1	2	0	6	1	4	1	3	2	3	3	3	2	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:94499675G>A	uc004arj.1	-	5	819	c.620C>T	c.(619-621)ACA>ATA	p.T207I	ROR2_uc004ari.1_Missense_Mutation_p.T67I|ROR2_uc004ark.2_Missense_Mutation_p.T207I	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	207	FZ.|Extracellular (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GCTCCTACCTGTGATTCGGTT	0.522													27	37					0	0	0	0	A	94499675	A	A	94499675	3	1	170	1	0	0	0	0	1	0	0	0	13592	1377	48	4	2231	4	ROR2	9	94499675	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	58748743	94499675	46713756	154	31990											
COL15A1	1306	broad.mit.edu	37	chr9	101800963	101800963	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcagtccttgatcaataTcacccatggattcatgaatt	11	16	5	9	0	4	2	4	2	0	0	5	3	5	3	2	1	0	0	2	1	3	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:101800963T>A	uc004azb.1	+	22	2629	c.2423T>A	c.(2422-2424)ATC>AAC	p.I808N		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	808	Nonhelical region 4 (NC4).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TTGATCAATATCACCCATGGA	0.478													27	99					0	0	0	0	A	101800963	A	A	101800963	3	1	170	1	0	0	0	0	1	0	0	0	3687	1435	50	5	2509	5	COL15A1	9	101800963	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	7301288	101800963	39412468	155	31991											
TEX10	54881	broad.mit.edu	37	chr9	103109584	103109584	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcacttaatatgtttgaaagGtgtgcatcaattataaatgg	14	15	8	4	0	2	1	2	1	0	0	2	1	2	1	0	2	1	2	0	2	7	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:103109584G>A	uc004bas.2	-	3	500	c.285C>T	c.(283-285)CAC>CAT	p.H95H	TEX10_uc011lvf.1_Silent_p.H30H|TEX10_uc011lvg.1_Silent_p.H98H|TEX10_uc011lvh.1_Silent_p.H30H|TEX10_uc004bat.2_Silent_p.H95H	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	95						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TGTTTGAAAGGTGTGCATCAA	0.388													56	174					0	0	0	0	A	103109584	A	A	103109584	2	1	170	1	0	0	0	0	0	0	0	1	15838	1252	44	4		4	TEX10	9	103109584	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1308621	103109584	38103847	156	31992											
ASTN2	23245	broad.mit.edu	37	chr9	119567939	119567939	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catctggaagacttggccttGgttcacatgctgggtccggt	6	12	13	10	1	2	1	1	0	1	1	3	2	3	2	2	5	1	2	2	5	1	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:119567939G>A	uc004bjs.1	-	13	2469	c.2368C>T	c.(2368-2370)CAA>TAA	p.Q790*	ASTN2_uc004bjr.1_Nonsense_Mutation_p.Q786*|ASTN2_uc004bjt.1_Nonsense_Mutation_p.Q739*	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	790	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						ACTTGGCCTTGGTTCACATGC	0.498													52	65					0	0	0	0	A	119567939	A	A	119567939	4	1	170	1	0	0	0	0	0	1	0	0	1067	1357	47	4	1927	4	ASTN2	9	119567939	Nonsense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	16458355	119567939	21645492	157	31993											
TLR4	7099	broad.mit.edu	37	chr9	120470905	120470905	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caaaatccccgacaacctccCcttctcaaccaagaacctgg	13	6	4	18	1	1	1	1	0	1	1	4	2	3	1	7	1	3	0	7	1	6	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:120470905C>A	uc004bjz.2	+	2	449	c.158C>A	c.(157-159)CCC>CAC	p.P53H	TLR4_uc004bka.2_Missense_Mutation_p.P13H|TLR4_uc004bkb.2_Intron	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	53	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						GACAACCTCCCCTTCTCAACC	0.433													37	100					1.90571e-15	2.53446e-15	1	0	A	120470905	A	A	120470905	3	1	170	1	0	0	0	0	1	0	0	0	16019	623	22	4	164	4	TLR4	9	120470905	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	902966	120470905	20742526	158	31994											
PTRH1	138428	broad.mit.edu	37	chr9	130479017	130479017	+	5'Flank	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgggagtgcctccttccaGgcctcatttccgcctctcct	4	12	9	16	1	2	0	1	0	1	0	6	1	5	1	7	2	1	0	7	2	0	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:130479017G>C	uc004bro.2	-						PTRH1_uc004brm.2_5'Flank|PTRH1_uc010mxm.2_5'UTR|PTRH1_uc011mah.1_5'UTR|TTC16_uc004brq.1_Intron|TTC16_uc011mai.1_Intron|TTC16_uc004brr.1_5'Flank	NM_001002913	NP_001002913	Q86Y79	PTH_HUMAN	peptidyl-tRNA hydrolase 1 homolog						translation		aminoacyl-tRNA hydrolase activity|protein binding				0						CCTCCTTCCAGGCCTCATTTC	0.657													3	2					0	0	0	0	C	130479017	C	C	130479017	1	2	170	0	1	0	0	0	0	0	0	0	12881	1015	35	4		4	PTRH1	9	130479017	5'Flank	SNP	G	TCGA-CV-5432-01A-02D-1683-08	10008112	130479017	10734414	159	31995											
NUP214	8021	broad.mit.edu	37	chr9	134090708	134090708	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaggatgcagccaacaaaaAcccattcagctcggccagtg	13	6	9	13	1	2	0	2	0	0	0	3	1	2	1	3	2	5	2	3	2	3	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:134090708A>T	uc004cag.2	+	31	5813	c.5702A>T	c.(5701-5703)AAC>ATC	p.N1901I	NUP214_uc004cah.2_Missense_Mutation_p.N1891I|NUP214_uc004cai.2_Missense_Mutation_p.N1331I|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.N727I	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1901	Pro/Ser/Thr-rich.|11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GCCAACAAAAACCCATTCAGC	0.517			T	DEK|SET|ABL1	AML|T-ALL								40	39					0	0	0	0	T	134090708	T	T	134090708	3	4	170	1	0	0	0	0	1	0	0	0	10816	43	2	5	5824	5	NUP214	9	134090708	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	3611691	134090708	7122723	160	31996											
SNAPC4	6621	broad.mit.edu	37	chr9	139273626	139273626	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgggcttgggccgggggcCggttgaagccagcagggacg	5	6	20	10	3	0	1	0	1	0	0	0	2	0	2	3	6	2	3	3	6	1	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:139273626C>T	uc004chh.2	-	21	2662	c.2653G>A	c.(2653-2655)GGC>AGC	p.G885S		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	885					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGCCGGGGGCCGGTTGAAGCC	0.687													5	5					0	0	0	0	T	139273626	T	T	139273626	3	4	170	1	0	0	0	0	1	0	0	0	14901	652	23	1	1764	1	SNAPC4	9	139273626	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	5182918	139273626	1939805	161	31997											
NOTCH1	4851	broad.mit.edu	37	chr9	139402542	139402542	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcagtggtgcgtgttgccCgcgtccacacagagccctcc	5	7	13	16	4	0	1	0	0	0	1	2	1	2	1	4	2	3	2	4	2	0	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:139402542C>G	uc004chz.2	-	21	3375	c.3375G>C	c.(3373-3375)GCG>GCC	p.A1125A	NOTCH1_uc004cia.1_Silent_p.A355A	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1125	Extracellular (Potential).|EGF-like 29.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCGTGTTGCCCGCGTCCACAC	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			7	33					0	0	0	0	G	139402542	G	G	139402542	2	3	170	1	0	0	0	0	0	0	0	1	10601	639	23	3		3	NOTCH1	9	139402542	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	128916	139402542	1810889	162	31998											
NDOR1	27158	broad.mit.edu	37	chr9	140109611	140109611	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctacctgttggacctcatccCcgttatccggccgagggcct	5	10	10	16	3	1	0	1	0	0	0	3	2	3	1	7	3	1	2	7	3	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr9:140109611C>G	uc004clw.2	+	9	1241	c.1130C>G	c.(1129-1131)CCC>CGC	p.P377R	NDOR1_uc004clx.2_Missense_Mutation_p.P377R|NDOR1_uc011mes.1_Missense_Mutation_p.P377R|NDOR1_uc004cly.2_Missense_Mutation_p.P343R	NM_014434	NP_055249	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	377	FAD-binding FR-type.				cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GACCTCATCCCCGTTATCCGG	0.667													8	10					0	0	0	0	G	140109611	G	G	140109611	3	3	170	1	0	0	0	0	1	0	0	0	10303	623	22	4	1164	4	NDOR1	9	140109611	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	707069	140109611	1103820	163	31999											
ITGA8	8516	broad.mit.edu	37	chr10	15649744	15649744	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcacaagagggaagacgcGatgagcctgatggttatcaa	14	8	12	7	2	2	4	2	2	0	2	2	6	2	5	1	2	1	1	1	2	5	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:15649744G>T	uc001ioc.1	-	17	1696	c.1696C>A	c.(1696-1698)CGC>AGC	p.R566S	ITGA8_uc010qcb.1_Missense_Mutation_p.R551S	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	566	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GGGAAGACGCGATGAGCCTGA	0.453													123	65					4.50961e-65	6.60397e-65	1	0	T	15649744	T	T	15649744	3	4	170	1	0	0	0	0	1	0	0	0	7921	1058	37	3	1551	3	ITGA8	10	15649744	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08		15649744	119885003	164	32000											
ITGA8	8516	broad.mit.edu	37	chr10	15700997	15700997	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgatattaaaatgtctctaCctgttctcccgtgaaattct	10	17	5	9	1	3	2	0	2	3	0	5	2	3	2	2	0	1	1	2	0	5	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:15700997C>T	uc001ioc.1	-	10	948	c.948_splice	c.e10+1	p.Q316_splice	ITGA8_uc010qcb.1_Splice_Site_p.Q301_splice	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor						cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						AATGTCTCTACCTGTTCTCCC	0.279													13	11					0	0	0	0	T	15700997	T	T	15700997	5	4	170	1	0	0	0	0	0	0	1	0	7921	521	18	4	2326	4	ITGA8	10	15700997	Splice_Site	SNP	C	TCGA-CV-5432-01A-02D-1683-08	51253	15700997	119833750	165	32001											
BICC1	80114	broad.mit.edu	37	chr10	60562844	60562844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttatttcacagcagcactGacaggttgctctcagaccct	9	12	7	13	0	3	2	2	1	2	1	4	2	3	2	1	1	3	4	1	1	1	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:60562844G>A	uc001jki.1	+	15	2023	c.2023G>A	c.(2023-2025)GAC>AAC	p.D675N	BICC1_uc001jkj.1_Missense_Mutation_p.D316N	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	675					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						CAGCAGCACTGACAGGTTGCT	0.443													9	13					0	0	0	0	A	60562844	A	A	60562844	3	1	170	1	0	0	0	0	1	0	0	0	1430	1290	45	2	2081	2	BICC1	10	60562844	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	44861847	60562844	74971903	166	32002											
NPFFR1	64106	broad.mit.edu	37	chr10	72020482	72020482	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcttgcatgtggcattGtcgaagggccaccctgcaat	8	11	10	12	1	2	0	1	0	1	0	3	1	2	0	2	2	2	3	2	2	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:72020482G>A	uc010qjk.1	-	2	336	c.330C>T	c.(328-330)GAC>GAT	p.D110D		NM_022146	NP_071429	Q9GZQ6	NPFF1_HUMAN	neuropeptide FF receptor 1	112	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide receptor activity				0						ATGTGGCATTGTCGAAGGGCC	0.473													5	2					0	0	0	0	A	72020482	A	A	72020482	2	1	170	1	0	0	0	0	0	0	0	1	10631	1368	48	4		4	NPFFR1	10	72020482	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	11457638	72020482	63514265	167	32003											
ADAMTS14	140766	broad.mit.edu	37	chr10	72468365	72468365	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctttggcctgggagaccttcCcaacctgctgggcctggtgg	4	10	14	13	0	0	1	0	0	0	1	1	2	1	1	5	5	2	1	5	5	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:72468365C>G	uc001jrh.2	+	4	701	c.701C>G	c.(700-702)CCC>CGC	p.P234R	ADAMTS14_uc001jrg.2_Missense_Mutation_p.P234R	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	234					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						GGAGACCTTCCCAACCTGCTG	0.637													10	32					0	0	0	0	G	72468365	G	G	72468365	3	3	170	1	0	0	0	0	1	0	0	0	259	623	22	4	715	4	ADAMTS14	10	72468365	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	447883	72468365	63066382	168	32004											
UNC5B	219699	broad.mit.edu	37	chr10	73044575	73044575	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagtgcgtggcctggagcTccgcgggcaccaccaagagt	7	5	15	14	3	0	1	0	0	0	1	1	2	1	2	5	3	2	2	5	3	1	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:73044575T>G	uc001jro.2	+	3	848	c.403T>G	c.(403-405)TCC>GCC	p.S135A	UNC5B_uc001jrp.2_Missense_Mutation_p.S135A	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	135	Ig-like.|Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						GGCCTGGAGCTCCGCGGGCAC	0.677													18	42					0	0	0	0	G	73044575	G	G	73044575	3	3	170	1	0	0	0	0	1	0	0	0	17060	1551	54	5	413	5	UNC5B	10	73044575	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	576210	73044575	62490172	169	32005											
POLR3A	11128	broad.mit.edu	37	chr10	79764513	79764513	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcagccaggctgctgctgCagcttgcccgtgttcagggc	4	9	15	13	1	1	0	1	0	0	0	1	0	1	0	2	2	7	7	2	2	0	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:79764513C>T	uc001jzn.2	-	16	2302	c.2208G>A	c.(2206-2208)CTG>CTA	p.L736L		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	736					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GCTGCTGCTGCAGCTTGCCCG	0.592													7	15					0	0	0	0	T	79764513	T	T	79764513	2	4	170	1	0	0	0	0	0	0	0	1	12283	697	25	4		4	POLR3A	10	79764513	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	6719938	79764513	55770234	170	32006											
GLUD1	2746	broad.mit.edu	37	chr10	88854150	88854150	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgacctcccaggagccgTcgtcgcgccggatggggaag	7	5	16	13	6	0	1	0	1	0	0	3	5	1	4	4	4	1	0	4	4	1	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:88854150T>C	uc001keh.2	-	1	474	c.377A>G	c.(376-378)GAC>GGC	p.D126G	FAM35A_uc001kei.3_5'Flank|GLUD1_uc001keg.2_5'Flank|GLUD1_uc010qmp.1_5'Flank	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	126					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCAGGAGCCGTCGTCGCGCCG	0.697													7	17					0	0	0	0	C	88854150	C	C	88854150	3	2	170	1	0	0	0	0	1	0	0	0	6513	1667	58	5	1351	5	GLUD1	10	88854150	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	9089637	88854150	46680597	171	32007											
DPCD	25911	broad.mit.edu	37	chr10	103360557	103360557	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtggcagcttgaagtaggaGacccagcgcccctaggagca	11	5	14	11	1	0	2	0	1	0	1	0	4	0	3	3	3	3	4	3	3	3	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:103360557G>C	uc001ktn.2	+	3	213	c.208G>C	c.(208-210)GAC>CAC	p.D70H	hsa-mir-3158-1|MI0014186_5'Flank	NM_015448	NP_056263	Q9BVM2	DPCD_HUMAN	DPCD protein	70							protein binding			skin(1)	1						TGAAGTAGGAGACCCAGCGCC	0.572													14	30					0	0	0	0	C	103360557	C	C	103360557	3	2	170	1	0	0	0	0	1	0	0	0	4733	942	33	2	218	2	DPCD	10	103360557	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	14506407	103360557	32174190	172	32008											
PDCD11	22984	broad.mit.edu	37	chr10	105174888	105174888	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggagaagaagtaccacatcGgggatgaggtcaagtgccgg	12	5	16	8	3	1	3	1	1	0	2	2	5	1	4	2	5	2	1	2	5	4	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:105174888G>T	uc001kwy.1	+	12	1585	c.1498G>T	c.(1498-1500)GGG>TGG	p.G500W		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	500	S1 motif 5.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GTACCACATCGGGGATGAGGT	0.547													7	18					5.68852e-11	7.08348e-11	1	0	T	105174888	T	T	105174888	3	4	170	1	0	0	0	0	1	0	0	0	11671	1116	39	3	1540	3	PDCD11	10	105174888	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1814331	105174888	30359859	173	32009											
PNLIPRP3	119548	broad.mit.edu	37	chr10	118215284	118215284	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacttgattggccacagcttGggagcacacctggctgggga	8	8	14	11	0	0	1	0	1	0	0	0	3	0	3	2	5	2	3	2	5	0	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:118215284G>C	uc001lcl.3	+	5	608	c.507G>C	c.(505-507)TTG>TTC	p.L169F		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	169					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		GCCACAGCTTGGGAGCACACC	0.423													3	30					0	0	0	0	C	118215284	C	C	118215284	3	2	170	1	0	0	0	0	1	0	0	0	12207	1339	47	4	525	4	PNLIPRP3	10	118215284	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	13040396	118215284	17319463	174	32010											
PNLIPRP1	5407	broad.mit.edu	37	chr10	118351331	118351331	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgcttttctgacactgagcCctggggcgggacagcaatca	8	9	13	11	1	2	2	1	2	1	0	2	3	2	3	1	3	3	2	1	3	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:118351331C>A	uc001lco.1	+	3	116	c.98C>A	c.(97-99)CCC>CAC	p.P33H	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.P33H|PNLIPRP1_uc001lcn.2_Missense_Mutation_p.P33H|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	33					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		GACACTGAGCCCTGGGGCGGG	0.522													29	87					7.26314e-15	9.56191e-15	1	0	A	118351331	A	A	118351331	3	1	170	1	0	0	0	0	1	0	0	0	12205	623	22	4	104	4	PNLIPRP1	10	118351331	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	136047	118351331	17183416	175	32011											
PNLIPRP2	5408	broad.mit.edu	37	chr10	118396416	118396416	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaacacaggagagagtggtAactttactagtaagtttcca	14	11	10	6	0	0	2	0	1	0	1	1	4	1	3	1	2	3	3	1	2	5	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:118396416A>G	uc001lcq.2	+	12	1083	c.1060A>G	c.(1060-1062)AAC>GAC	p.N354D	PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	353				N->Q: Loss of N-glycosylation.	galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		AGAGAGTGGTAACTTTACTAG	0.393													3	11					0	0	0	0	G	118396416	G	G	118396416	3	3	170	1	0	0	0	0	1	0	0	0	12206	362	13	5	1097	5	PNLIPRP2	10	118396416	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	45085	118396416	17138331	176	32012											
GPR26	2849	broad.mit.edu	37	chr10	125447567	125447567	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttactgcgacaccagtaccGcaaaagctgcaaggagattc	13	7	9	12	2	0	1	0	0	0	1	1	3	0	1	2	1	5	4	2	1	5	3	rs141519939		TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:125447567G>T	uc001lhh.2	+	3	958	c.905G>T	c.(904-906)CGC>CTC	p.R302L		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	302	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				CACCAGTACCGCAAAAGCTGC	0.597													19	36					1.56452e-12	1.99911e-12	1	0	T	125447567	T	T	125447567	3	4	170	1	0	0	0	0	1	0	0	0	6722	1087	38	3	915	3	GPR26	10	125447567	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	7051151	125447567	10087180	177	32013											
MKI67	4288	broad.mit.edu	37	chr10	129913803	129913803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagattttggtcttgacttaCgcgagaccaacagttgggtc	9	12	11	9	2	1	3	0	1	1	2	2	4	1	3	1	2	2	1	1	2	2	5	rs145509852	byFrequency	TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:129913803C>T	uc001lke.2	-	7	1064	c.869G>A	c.(868-870)CGT>CAT	p.R290H	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	290					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCTTGACTTACGCGAGACCAA	0.498													17	42					0	0	0	0	T	129913803	T	T	129913803	3	4	170	1	0	0	0	0	1	0	0	0	9651	536	19	1	8937	1	MKI67	10	129913803	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	4466236	129913803	5620944	178	32014											
INPP5A	3632	broad.mit.edu	37	chr10	134563023	134563023	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttgctgtctttctgcagacGctctgcacaaaagccaccat	9	11	8	13	1	3	1	0	0	3	1	3	1	3	1	2	0	4	5	2	0	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr10:134563023G>A	uc001llp.2	+	10	983	c.735G>A	c.(733-735)ACG>ACA	p.T245T	INPP5A_uc001llo.1_Silent_p.T245T|INPP5A_uc001llq.2_Intron	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	245					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		TTCTGCAGACGCTCTGCACAA	0.602													7	20					0	0	0	0	A	134563023	A	A	134563023	2	1	170	1	0	0	0	0	0	0	0	1	7793	1074	38	1		1	INPP5A	10	134563023	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	4649220	134563023	971724	179	32015											
TRIM22	10346	broad.mit.edu	37	chr11	5730527	5730527	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtagtctgaataaaaggaaGagctctgggtttgcttttga	12	13	12	4	0	2	3	0	2	2	1	2	4	2	4	0	2	2	4	0	2	5	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:5730527G>A	uc001mbr.2	+	8	1423	c.1146G>A	c.(1144-1146)AAG>AAA	p.K382K	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.2_Silent_p.K378K|TRIM22_uc010qzm.1_Silent_p.K210K|TRIM22_uc009yeu.2_Silent_p.K193K|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	382	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		ATAAAAGGAAGAGCTCTGGGT	0.378													13	44					0	0	0	0	A	5730527	A	A	5730527	2	1	170	1	0	0	0	0	0	0	0	1	16563	933	33	2		2	TRIM22	11	5730527	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08		5730527	129275989	180	32016											
C11orf42	160298	broad.mit.edu	37	chr11	6231257	6231257	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggccactaccaagcctcCtggagcaggcaggatctgag	9	6	14	12	0	1	1	0	1	1	0	2	3	2	3	4	5	3	2	4	5	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:6231257C>T	uc001mcj.2	+	2	298	c.250C>T	c.(250-252)CTG>TTG	p.L84L		NM_173525	NP_775796	Q8N5U0	CK042_HUMAN	hypothetical protein LOC160298	84										ovary(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.95e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCAAGCCTCCTGGAGCAGGC	0.612													15	10					0	0	0	0	T	6231257	T	T	6231257	2	4	170	1	0	0	0	0	0	0	0	1	1647	680	24	4		4	C11orf42	11	6231257	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	500730	6231257	128775259	181	32017											
OR5P3	120066	broad.mit.edu	37	chr11	7847305	7847305	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgtgactgatgaggagtacCcaatgtctacaaaggccaaa	14	8	11	8	0	1	3	0	3	1	0	1	4	1	4	2	2	2	1	2	2	5	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:7847305C>G	uc010rbg.1	-	1	215	c.215G>C	c.(214-216)GGG>GCG	p.G72A		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGAGGAGTACCCAATGTCTAC	0.438													40	23					0	0	0	0	G	7847305	G	G	7847305	3	3	170	1	0	0	0	0	1	0	0	0	11233	623	22	4	723	4	OR5P3	11	7847305	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	1616048	7847305	127159211	182	32018											
PTPRJ	5795	broad.mit.edu	37	chr11	48181590	48181590	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggaccatcagagatttcAcagtgaaaaatgtaagtaag	18	9	9	5	0	2	2	2	1	0	1	2	4	2	3	1	1	0	2	1	1	5	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:48181590A>T	uc001ngp.3	+	22	3902	c.3547A>T	c.(3547-3549)ACA>TCA	p.T1183S		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1183	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						CAGAGATTTCACAGTGAAAAA	0.388													60	35					0	0	0	0	T	48181590	T	T	48181590	3	4	170	1	0	0	0	0	1	0	0	0	12869	159	6	5	3642	5	PTPRJ	11	48181590	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	40334285	48181590	86824926	183	32019											
OR4C16	219428	broad.mit.edu	37	chr11	55340052	55340052	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctgtggcctgggtgggatCctgtgtgcattctttagttc	3	15	15	8	0	1	0	0	0	1	0	3	1	2	1	2	4	1	3	2	4	1	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:55340052C>A	uc010rih.1	+	1	449	c.449C>A	c.(448-450)TCC>TAC	p.S150Y		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TGGGTGGGATCCTGTGTGCAT	0.498													20	58					1.00905e-13	1.31076e-13	1	0	A	55340052	A	A	55340052	3	1	170	1	0	0	0	0	1	0	0	0	11103	855	30	2	451	2	OR4C16	11	55340052	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	7158462	55340052	79666464	184	32020											
OR8H3	390152	broad.mit.edu	37	chr11	55890010	55890010	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgataatccgcctggacctCcagcttcacactcccatgta	9	11	6	15	1	1	1	1	1	0	0	4	2	4	2	5	1	1	2	5	1	2	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:55890010C>A	uc001nii.1	+	1	162	c.162C>A	c.(160-162)CTC>CTA	p.L54L		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					GCCTGGACCTCCAGCTTCACA	0.433													60	308					7.1157e-29	1.01542e-28	1	0	A	55890010	A	A	55890010	2	1	170	1	0	0	0	0	0	0	0	1	11293	842	30	2		2	OR8H3	11	55890010	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	549958	55890010	79116506	185	32021											
OR5T2	219464	broad.mit.edu	37	chr11	56000380	56000380	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaatagtacatgggtttgtgGagctgggaatccctaatgac	12	11	12	6	0	0	1	0	1	0	0	1	3	1	3	1	3	2	3	1	3	5	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:56000380G>A	uc010rjc.1	-	1	282	c.282C>T	c.(280-282)CTC>CTT	p.L94L		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	94	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGGGTTTGTGGAGCTGGGAAT	0.393													6	92					0	0	0	0	A	56000380	A	A	56000380	2	1	170	1	0	0	0	0	0	0	0	1	11236	1161	41	2		2	OR5T2	11	56000380	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	110370	56000380	79006136	186	32022											
OR5T2	219464	broad.mit.edu	37	chr11	56000428	56000428	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcagtcctaaatttcccatGagagtgaagaggtagattgc	13	11	10	7	0	1	4	1	2	0	3	3	5	3	4	2	1	1	1	2	1	4	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:56000428G>A	uc010rjc.1	-	1	234	c.234C>T	c.(232-234)CTC>CTT	p.L78L		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	78	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AATTTCCCATGAGAGTGAAGA	0.413													9	77					0	0	0	0	A	56000428	A	A	56000428	2	1	170	1	0	0	0	0	0	0	0	1	11236	1277	45	2		2	OR5T2	11	56000428	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	48	56000428	79006088	187	32023											
OR8K3	219473	broad.mit.edu	37	chr11	56086376	56086376	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acacatgaaattgaattgatAattctgatctttgcagctat	14	15	6	6	0	2	4	0	4	2	0	2	4	2	4	0	0	2	2	0	0	4	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:56086376A>T	uc010rjf.1	+	1	594	c.594A>T	c.(592-594)ATA>ATT	p.I198I		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TTGAATTGATAATTCTGATCT	0.363													22	70					0	0	0	0	T	56086376	T	T	56086376	2	4	170	1	0	0	0	0	0	0	0	1	11298	352	13	5		5	OR8K3	11	56086376	Silent	SNP	A	TCGA-CV-5432-01A-02D-1683-08	85948	56086376	78920140	188	32024											
OR5M10	390167	broad.mit.edu	37	chr11	56344727	56344727	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtcagcagtgtctgagaGagcccattaaggaagccata	14	7	12	8	0	2	2	1	1	1	1	2	4	2	3	2	2	3	1	2	2	4	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:56344727G>A	uc001niz.1	-	1	471	c.471C>T	c.(469-471)CTC>CTT	p.L157L		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTGTCTGAGAGAGCCCATTAA	0.468													22	72					0	0	0	0	A	56344727	A	A	56344727	2	1	170	1	0	0	0	0	0	0	0	1	11227	929	33	2		2	OR5M10	11	56344727	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	258351	56344727	78661789	189	32025											
OR5B21	219968	broad.mit.edu	37	chr11	58275518	58275518	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggaggaggggtatctgaaGattggggtcatctgttaatc	10	11	15	5	0	3	2	1	1	2	1	4	4	3	4	0	6	0	2	0	6	3	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:58275518G>A	uc010rki.1	-	1	61	c.61C>T	c.(61-63)CTT>TTT	p.L21F		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GGTATCTGAAGATTGGGGTCA	0.468													23	33					0	0	0	0	A	58275518	A	A	58275518	3	1	170	1	0	0	0	0	1	0	0	0	11205	942	33	2	870	2	OR5B21	11	58275518	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1930791	58275518	76730998	190	32026											
DTX4	23220	broad.mit.edu	37	chr11	58949291	58949291	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggtgtgggagtgggagaaCgacaatggctcctggacgcc	8	7	18	8	2	0	1	0	0	0	1	1	5	1	3	2	5	1	1	2	5	2	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:58949291C>T	uc001nns.2	+	2	548	c.291C>T	c.(289-291)AAC>AAT	p.N97N	DTX4_uc001nnr.2_Translation_Start_Site	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	97	WWE 2.				Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				AGTGGGAGAACGACAATGGCT	0.617													13	43					0	0	0	0	T	58949291	T	T	58949291	2	4	170	1	0	0	0	0	0	0	0	1	4819	535	19	1		1	DTX4	11	58949291	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	673773	58949291	76057225	191	32027											
OR4D11	219986	broad.mit.edu	37	chr11	59271271	59271271	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttgacatctgcttctccTccacaactgctcctaaagtc	8	13	4	16	0	2	1	0	1	2	0	7	1	5	1	4	0	3	2	4	0	3	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:59271271T>C	uc001noa.1	+	1	223	c.223T>C	c.(223-225)TCC>CCC	p.S75P		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTGCTTCTCCTCCACAACTGC	0.488													41	80					0	0	0	0	C	59271271	C	C	59271271	3	2	170	1	0	0	0	0	1	0	0	0	11109	1551	54	5	225	5	OR4D11	11	59271271	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	321980	59271271	75735245	192	32028											
SLC22A9	114571	broad.mit.edu	37	chr11	63137901	63137901	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atggctgggtgtatgacagaAtctccttctcatccaccatc	9	12	8	12	0	2	2	1	1	2	1	6	2	3	2	3	2	0	2	3	2	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:63137901A>G	uc001nww.2	+	1	641	c.373A>G	c.(373-375)ATC>GTC	p.I125V	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	125	Extracellular (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						GTATGACAGAATCTCCTTCTC	0.493													11	32					0	0	0	0	G	63137901	G	G	63137901	3	3	170	1	0	0	0	0	1	0	0	0	14525	101	4	5	375	5	SLC22A9	11	63137901	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	3866630	63137901	71868615	193	32029											
MTL5	9633	broad.mit.edu	37	chr11	68518104	68518104	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctcggggctgggcagccCgcccggcagagggccctcct	4	5	15	17	3	0	1	0	0	0	1	3	1	2	1	5	5	1	3	5	5	0	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:68518104C>A	uc001ooc.2	-	2	165	c.25G>T	c.(25-27)GGG>TGG	p.G9W	MTL5_uc001ood.1_Missense_Mutation_p.G9W|MTL5_uc009ysi.1_Missense_Mutation_p.G9W|MTL5_uc001ooe.2_Missense_Mutation_p.G9W	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	9					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			CTGGGCAGCCCGCCCGGCAGA	0.697													6	10					0.000274275	0.000292211	1	0	A	68518104	A	A	68518104	3	1	170	1	0	0	0	0	1	0	0	0	9989	652	23	3	1541	3	MTL5	11	68518104	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	5380203	68518104	66488412	194	32030											
EXPH5	23086	broad.mit.edu	37	chr11	108381350	108381350	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagagataaatggtcaaaGccagatctgcttccactttg	13	10	8	10	0	2	2	1	0	1	2	3	3	3	2	3	1	2	1	3	1	4	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:108381350G>A	uc001pkk.2	-	6	4995	c.4884C>T	c.(4882-4884)GGC>GGT	p.G1628G	EXPH5_uc010rvy.1_Silent_p.G1440G|EXPH5_uc010rvz.1_Silent_p.G1472G|EXPH5_uc010rwa.1_Silent_p.G1552G	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1628					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AATGGTCAAAGCCAGATCTGC	0.488													22	16					0	0	0	0	A	108381350	A	A	108381350	2	1	170	1	0	0	0	0	0	0	0	1	5347	958	34	4		4	EXPH5	11	108381350	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	39863246	108381350	26625166	195	32031											
OR8D4	338662	broad.mit.edu	37	chr11	123777713	123777713	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaactctcctgctccagcaCttatattgatgagcttttga	10	15	6	10	0	1	3	0	3	1	0	3	3	2	3	2	0	4	3	2	0	4	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr11:123777713C>T	uc010saa.1	+	1	575	c.575C>T	c.(574-576)ACT>ATT	p.T192I		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TGCTCCAGCACTTATATTGAT	0.373													10	108					0	0	0	0	T	123777713	T	T	123777713	3	4	170	1	0	0	0	0	1	0	0	0	11287	565	20	4	577	4	OR8D4	11	123777713	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	15396363	123777713	11228803	196	32032											
SLC2A14	144195	broad.mit.edu	37	chr12	7973850	7973850	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatagtattaaccacaccCgcgctgatggtggcatagat	13	9	10	9	2	0	3	0	1	0	2	0	3	0	3	2	2	1	3	2	2	5	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:7973850C>T	uc001qtk.2	-	13	1798	c.1005G>A	c.(1003-1005)GCG>GCA	p.A335A	SLC2A14_uc001qtl.2_Silent_p.A312A|SLC2A14_uc001qtm.2_Silent_p.A312A|SLC2A14_uc010sgg.1_Silent_p.A226A|SLC2A14_uc001qtn.2_Silent_p.A335A|SLC2A14_uc001qto.2_5'UTR|SLC2A14_uc010sgh.1_Silent_p.A350A	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	335	Helical; Name=8; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		TAACCACACCCGCGCTGATGG	0.413													68	62					0	0	0	0	T	7973850	T	T	7973850	2	4	170	1	0	0	0	0	0	0	0	1	14607	639	23	1		1	SLC2A14	12	7973850	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08		7973850	125878045	197	32033											
TAS2R31	259290	broad.mit.edu	37	chr12	11183779	11183779	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaaccaactctggagacCgccagagcagtgagaatctg	14	5	11	11	1	2	3	0	1	2	3	2	5	2	3	3	1	4	2	3	1	3	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:11183779C>T	uc001qzo.1	-	1	228	c.156G>A	c.(154-156)GCG>GCA	p.A52A	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	52	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						CTCTGGAGACCGCCAGAGCAG	0.378													41	131					0	0	0	0	T	11183779	T	T	11183779	2	4	170	1	0	0	0	0	0	0	0	1	15640	639	23	1		1	TAS2R31	12	11183779	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	3209929	11183779	122668116	198	32034											
ITPR2	3709	broad.mit.edu	37	chr12	26774192	26774192	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatctgccttgatttgcttgTagttatctacgtcttgatta	7	19	8	7	1	3	2	0	2	3	0	3	3	3	2	1	0	3	3	1	0	4	8			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:26774192T>C	uc001rhg.2	-	26	3743	c.3326A>G	c.(3325-3327)TAC>TGC	p.Y1109C		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1109	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					GATTTGCTTGTAGTTATCTAC	0.368													11	264					0	0	0	0	C	26774192	C	C	26774192	3	2	170	1	0	0	0	0	1	0	0	0	7960	1638	57	5	4907	5	ITPR2	12	26774192	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	15590413	26774192	107077703	199	32035											
C12orf40	283461	broad.mit.edu	37	chr12	40041680	40041680	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actccatcatctttttcagtGgagttaccttctaacagaca	11	14	5	11	0	4	1	2	0	2	1	5	2	5	2	2	1	2	1	2	1	2	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:40041680G>T	uc001rmc.2	+	6	638	c.471G>T	c.(469-471)GTG>GTT	p.V157V	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	157										ovary(6)	6						CTTTTTCAGTGGAGTTACCTT	0.383													8	32					0.000157383	0.000169991	1	0	T	40041680	T	T	40041680	2	4	170	1	0	0	0	0	0	0	0	1	1692	1335	47	4		4	C12orf40	12	40041680	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	13267488	40041680	93810215	200	32036											
ADAMTS20	80070	broad.mit.edu	37	chr12	43833759	43833759	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aattctttcaactgcgttatTtgatccactgtattcaataa	12	17	4	8	1	3	1	2	1	1	0	4	1	4	1	1	0	2	2	1	0	6	7			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:43833759T>A	uc010skx.1	-	17	2404	c.2404A>T	c.(2404-2406)AAT>TAT	p.N802Y	ADAMTS20_uc001rno.1_5'Flank|ADAMTS20_uc001rnp.1_5'Flank	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	802	Spacer.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACTGCGTTATTTGATCCACTG	0.299													8	3					0	0	0	0	A	43833759	A	A	43833759	3	1	170	1	0	0	0	0	1	0	0	0	266	1841	64	5	3419	5	ADAMTS20	12	43833759	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	3792079	43833759	90018136	201	32037											
DBX2	440097	broad.mit.edu	37	chr12	45410203	45410203	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tagtctttctgaaggttctgGagaattctccctccatcttg	7	16	8	10	0	5	2	0	1	5	1	7	3	6	2	2	2	0	1	2	2	3	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:45410203G>T	uc001rok.1	-	4	1058	c.886C>A	c.(886-888)CCA>ACA	p.P296T		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	296						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GAAGGTTCTGGAGAATTCTCC	0.502													12	43					7.03913e-09	8.46861e-09	1	0	T	45410203	T	T	45410203	3	4	170	1	0	0	0	0	1	0	0	0	4277	1174	41	2	137	2	DBX2	12	45410203	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1576444	45410203	88441692	202	32038											
KRT6C	286887	broad.mit.edu	37	chr12	52863216	52863216	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgttgacttgtccaacgcCttcgccattcagcctgtgga	7	11	10	13	3	1	1	1	1	0	0	3	3	2	2	4	1	2	1	4	1	1	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:52863216C>G	uc001sal.3	-	8	1486	c.1438G>C	c.(1438-1440)GGC>CGC	p.G480R		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	480	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		TGTCCAACGCCTTCGCCATTC	0.597													3	38					0	0	0	0	G	52863216	G	G	52863216	3	3	170	1	0	0	0	0	1	0	0	0	8521	681	24	4	264	4	KRT6C	12	52863216	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	7453013	52863216	80988679	203	32039											
CAND1	55832	broad.mit.edu	37	chr12	67699449	67699449	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaaaccagagagctttgaaActgggtactctttctgccct	12	11	8	10	0	2	2	0	1	2	1	2	3	2	2	2	1	5	2	2	1	4	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:67699449A>T	uc001stn.2	+	10	2438	c.2001A>T	c.(1999-2001)AAA>AAT	p.K667N	CAND1_uc001sto.2_Missense_Mutation_p.K177N	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	667	HEAT 15.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		GAGCTTTGAAACTGGGTACTC	0.423													82	28					0	0	0	0	T	67699449	T	T	67699449	3	4	170	1	0	0	0	0	1	0	0	0	2627	40	2	5	2039	5	CAND1	12	67699449	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	14836233	67699449	66152446	204	32040											
MYF5	4617	broad.mit.edu	37	chr12	81110924	81110924	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taccgtcccccgagggtgaaTttggggacgagtttgtgccg	6	10	15	10	4	0	1	0	1	0	0	1	4	1	2	4	3	2	1	4	3	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:81110924T>A	uc001szg.2	+	1	217	c.82T>A	c.(82-84)TTT>ATT	p.F28I		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	28					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CGAGGGTGAATTTGGGGACGA	0.622													21	14					0	0	0	0	A	81110924	A	A	81110924	3	1	170	1	0	0	0	0	1	0	0	0	10080	1493	52	5	84	5	MYF5	12	81110924	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	13411475	81110924	52740971	205	32041											
UTP20	27340	broad.mit.edu	37	chr12	101767436	101767436	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcaatgatgactctgccaCgtgcaaaaagatggcatcca	14	8	9	10	1	2	3	1	2	1	1	3	4	3	3	2	1	2	2	2	1	3	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:101767436C>A	uc001tia.1	+	54	7178	c.7022C>A	c.(7021-7023)ACG>AAG	p.T2341K		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2341					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						GACTCTGCCACGTGCAAAAAG	0.438													13	28					2.27111e-07	2.64287e-07	1	0	A	101767436	A	A	101767436	3	1	170	1	0	0	0	0	1	0	0	0	17167	536	19	3	7236	3	UTP20	12	101767436	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	20656512	101767436	32084459	206	32042											
ACAD10	80724	broad.mit.edu	37	chr12	112186135	112186135	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcaggcatcctggatcctCgttgccaactctgtgtgttt	5	14	11	11	1	1	0	0	0	1	0	4	1	3	1	3	3	2	4	3	3	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:112186135C>A	uc001tsq.2	+	17	2700	c.2500C>A	c.(2500-2502)CGT>AGT	p.R834S	ACAD10_uc001tsp.2_Missense_Mutation_p.R834S|ACAD10_uc009zvx.2_Missense_Mutation_p.R865S|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	834							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						CCTGGATCCTCGTTGCCAACT	0.537													42	24					2.24893e-16	3.02176e-16	1	0	A	112186135	A	A	112186135	3	1	170	1	0	0	0	0	1	0	0	0	108	884	31	3	2659	3	ACAD10	12	112186135	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	10418699	112186135	21665760	207	32043											
C12orf52	84934	broad.mit.edu	37	chr12	113629589	113629589	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctaccccacgacgaggtggGgccacccagaaaccaaagcc	12	3	10	16	2	1	1	0	0	1	1	1	3	1	1	6	3	3	0	6	3	3	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr12:113629589G>A	uc001tur.1	+	4	1245	c.777G>A	c.(775-777)GGG>GGA	p.G259G	C12orf52_uc009zwg.1_Silent_p.G256G|C12orf52_uc001tus.1_Silent_p.G259G|C12orf52_uc001tut.1_Silent_p.G283G	NM_032848	NP_116237	Q96K30	RITA_HUMAN	hypothetical protein LOC84934	259	Interaction with tubulin.				negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding				0						GACGAGGTGGGGCCACCCAGA	0.602													30	16					0	0	0	0	A	113629589	A	A	113629589	2	1	170	1	0	0	0	0	0	0	0	1	1703	1219	43	4		4	C12orf52	12	113629589	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1443454	113629589	20222306	208	32044											
ERCC5	2073	broad.mit.edu	37	chr13	103514530	103514530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacccctccttctccaagaaCtttactagctatgcaagctg	10	12	5	14	0	1	1	0	0	1	1	3	1	2	1	4	0	6	3	4	0	7	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr13:103514530C>G	uc001vpw.2	+	8	1474	c.1031C>G	c.(1030-1032)ACT>AGT	p.T344S	ERCC5_uc001vpu.1_Missense_Mutation_p.T798S|ERCC5_uc010tjb.1_Missense_Mutation_p.T344S|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.T176S	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	344					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TCTCCAAGAACTTTACTAGCT	0.512			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				12	67					0	0	0	0	G	103514530	G	G	103514530	3	3	170	1	0	0	0	0	1	0	0	0	5240	565	20	4	1061	4	ERCC5	13	103514530	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08		103514530	11655348	209	32045											
TGM1	7051	broad.mit.edu	37	chr14	24727794	24727795	+	In_Frame_Ins	INS	-	ATGTCC	ATGTCC																															tcatgttctcgtcgaagtagINSatgtccatggtaagggatgt																										TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:24727794_24727795insATGTCC	uc001wod.2	-	8	1368_1369	c.1244_1245insGGACAT	c.(1243-1245)ATC>ATGGACATC	p.414_415insMD	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	414_415					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	CGTCGAAGTAGATGTCCATGGT	0.569													---	---	---								ATGTCC	24727795	ATGTCC	ATGTCC	24727794	7	5	170	1	0	1	1	0	0	0	0	0	15895	932	33	0	1240	0	TGM1	14	24727794	In_Frame_Ins	INS	-	TCGA-CV-5432-01A-02D-1683-08		24727794	82621746	210	32046											
BAZ1A	11177	broad.mit.edu	37	chr14	35262044	35262044	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcttcagctattgcctGgaagattgcagtcaggaaga	10	13	10	8	0	4	2	2	0	2	2	4	4	4	4	1	2	3	2	1	2	3	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:35262044G>A	uc001wsk.2	-	12	2015	c.1447C>T	c.(1447-1449)CAG>TAG	p.Q483*	BAZ1A_uc001wsl.2_Nonsense_Mutation_p.Q483*	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	483	DDT.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		GCTATTGCCTGGAAGATTGCA	0.398													16	87					0	0	0	0	A	35262044	A	A	35262044	4	1	170	1	0	0	0	0	0	1	0	0	1331	1357	47	4	3287	4	BAZ1A	14	35262044	Nonsense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	10534250	35262044	72087496	211	32047											
LRFN5	145581	broad.mit.edu	37	chr14	42356347	42356347	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttgagaagatggttagcttGcatacccttagtttggatca	10	14	11	6	0	1	2	1	1	0	2	1	4	1	3	1	2	3	5	1	2	4	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:42356347G>T	uc001wvm.2	+	3	1717	c.519G>T	c.(517-519)TTG>TTT	p.L173F	LRFN5_uc010ana.2_Missense_Mutation_p.L173F	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	173	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGGTTAGCTTGCATACCCTTA	0.413										HNSCC(30;0.082)			36	19					3.93418e-24	5.53333e-24	1	0	T	42356347	T	T	42356347	3	4	170	1	0	0	0	0	1	0	0	0	8991	1310	46	4	521	4	LRFN5	14	42356347	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	7094303	42356347	64993193	212	32048											
LRFN5	145581	broad.mit.edu	37	chr14	42356804	42356804	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggatttctcctgaagggAagcttatttcaaatgcaaca	13	12	8	8	0	2	1	1	1	1	0	3	3	2	3	1	2	3	2	1	2	5	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:42356804A>T	uc001wvm.2	+	3	2174	c.976A>T	c.(976-978)AAG>TAG	p.K326*	LRFN5_uc010ana.2_Nonsense_Mutation_p.K326*	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	326	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TCCTGAAGGGAAGCTTATTTC	0.458										HNSCC(30;0.082)			17	154					0	0	0	0	T	42356804	T	T	42356804	4	4	170	1	0	0	0	0	0	1	0	0	8991	247	9	5	978	5	LRFN5	14	42356804	Nonsense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	457	42356804	64992736	213	32049											
FSCB	84075	broad.mit.edu	37	chr14	44976037	44976037	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttgctgaagctcagaagAtactctaatagactcatagg	14	11	9	7	0	3	4	2	1	1	3	3	4	3	4	0	1	3	3	0	1	6	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:44976037A>G	uc001wvn.2	-	1	463	c.154T>C	c.(154-156)TCT>CCT	p.S52P		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	52						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		AGCTCAGAAGATACTCTAATA	0.418													71	173					0	0	0	0	G	44976037	G	G	44976037	3	3	170	1	0	0	0	0	1	0	0	0	6100	333	12	5	2327	5	FSCB	14	44976037	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	2619233	44976037	62373503	214	32050											
SOCS4	122809	broad.mit.edu	37	chr14	55510854	55510854	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggctcctagaacattataaGgacccaagcgcctgtatgtt	11	10	10	10	1	0	1	0	0	0	1	1	2	1	2	3	2	2	3	3	2	6	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:55510854G>A	uc001xbo.2	+	3	1660	c.1095G>A	c.(1093-1095)AAG>AAA	p.K365K	SOCS4_uc001xbp.2_Silent_p.K365K	NM_199421	NP_955453	Q8WXH5	SOCS4_HUMAN	suppressor of cytokine signaling 4	365	SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth					ovary(1)|kidney(1)	2						AACATTATAAGGACCCAAGCG	0.423													44	47					0	0	0	0	A	55510854	A	A	55510854	2	1	170	1	0	0	0	0	0	0	0	1	14980	991	35	4		4	SOCS4	14	55510854	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	10534817	55510854	51838686	215	32051											
SYNE2	23224	broad.mit.edu	37	chr14	64468757	64468757	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cataaaatggccatccagggAtttcatctcattgatgctga	12	12	8	9	0	2	2	2	2	1	0	4	3	3	3	2	2	1	1	2	2	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:64468757A>G	uc001xgm.2	+	29	3974	c.3744A>G	c.(3742-3744)GGA>GGG	p.G1248G	SYNE2_uc001xgl.2_Silent_p.G1248G	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1248	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCATCCAGGGATTTCATCTCA	0.418													94	99					0	0	0	0	G	64468757	G	G	64468757	2	3	170	1	0	0	0	0	0	0	0	1	15512	320	12	5		5	SYNE2	14	64468757	Silent	SNP	A	TCGA-CV-5432-01A-02D-1683-08	8957903	64468757	42880783	216	32052											
DCAF5	8816	broad.mit.edu	37	chr14	69542127	69542127	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catcagagcccgaaaggataTactgttggaacaaaaaatat	18	8	8	7	1	1	1	1	0	0	1	1	4	1	3	1	2	3	1	1	2	8	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:69542127T>C	uc001xkp.2	-	7	1100	c.881A>G	c.(880-882)TAT>TGT	p.Y294C	DCAF5_uc001xkq.2_Missense_Mutation_p.Y293C	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	294	WD 5.					CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2						CGAAAGGATATACTGTTGGAA	0.264													40	101					0	0	0	0	C	69542127	C	C	69542127	3	2	170	1	0	0	0	0	1	0	0	0	4290	1420	49	5	1959	5	DCAF5	14	69542127	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	5073370	69542127	37807413	217	32053											
ADAM21	8747	broad.mit.edu	37	chr14	70924226	70924226	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acagcttcataatggcagtgGatgggaccctcgtgtacatc	10	10	11	10	1	1	0	1	0	0	0	3	2	1	2	1	3	2	3	1	3	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:70924226G>C	uc001xmd.2	+	1	10	c.10G>C	c.(10-12)GAT>CAT	p.D4H		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	4					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AATGGCAGTGGATGGGACCCT	0.537													16	186					0	0	0	0	C	70924226	C	C	70924226	3	2	170	1	0	0	0	0	1	0	0	0	243	1174	41	2	12	2	ADAM21	14	70924226	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1382099	70924226	36425314	218	32054											
C14orf118	55668	broad.mit.edu	37	chr14	76633013	76633013	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actctttttacagtgaaaccAgcagtgtgtgtagcagcagt	11	12	10	8	0	1	1	0	1	1	0	1	1	1	1	1	0	5	4	1	0	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:76633013A>C	uc001xsh.2	+	3	756	c.670A>C	c.(670-672)AGC>CGC	p.S224R	C14orf118_uc001xsi.2_Missense_Mutation_p.S224R|C14orf118_uc001xsj.1_Missense_Mutation_p.S224R|C14orf118_uc001xsk.1_Missense_Mutation_p.S224R|C14orf118_uc001xsl.2_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	224										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		CAGTGAAACCAGCAGTGTGTG	0.433													15	31					0	0	0	0	C	76633013	C	C	76633013	3	2	170	1	0	0	0	0	1	0	0	0	1747	188	7	5	676	5	C14orf118	14	76633013	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	5708787	76633013	30716527	219	32055											
IFI27L1	122509	broad.mit.edu	37	chr14	94568245	94568245	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatcctccatagcagccaaGatgatgtctacagcagccat	12	8	8	13	0	1	2	0	1	1	1	3	2	3	2	4	0	5	3	4	0	3	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr14:94568245G>T	uc001ycl.2	+	4	355	c.147G>T	c.(145-147)AAG>AAT	p.K49N	IFI27L1_uc001yck.2_Missense_Mutation_p.K49N	NM_206949	NP_996832	Q96BM0	I27L1_HUMAN	interferon, alpha-inducible protein 27-like 1	49						integral to membrane					0						TAGCAGCCAAGATGATGTCTA	0.592													13	49					2.23348e-06	2.52397e-06	1	0	T	94568245	T	T	94568245	3	4	170	1	0	0	0	0	1	0	0	0	7552	933	33	2	157	2	IFI27L1	14	94568245	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	17935232	94568245	12781295	220	32056											
C15orf2	23742	broad.mit.edu	37	chr15	24921689	24921689	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aacagcatgagtgagaaggcCcaggcgtctccagcgagctc	11	5	13	12	2	1	2	0	2	1	1	3	4	1	2	2	2	4	2	2	2	2	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr15:24921689C>T	uc001ywo.2	+	1	1149	c.675C>T	c.(673-675)GCC>GCT	p.A225A		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	225					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GTGAGAAGGCCCAGGCGTCTC	0.612													8	35					0	0	0	0	T	24921689	T	T	24921689	2	4	170	1	0	0	0	0	0	0	0	1	1790	610	22	4		4	C15orf2	15	24921689	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08		24921689	77609703	221	32057											
ATP10A	57194	broad.mit.edu	37	chr15	25962006	25962006	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctcctgatgcctcgccacGgctaggctcttgtcacactc	5	11	9	16	2	2	1	1	1	1	0	5	1	3	1	3	2	2	3	3	2	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr15:25962006G>T	uc010ayu.2	-	9	1753	c.1647C>A	c.(1645-1647)GCC>GCA	p.A549A		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	549	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCCTCGCCACGGCTAGGCTCT	0.587													12	52					0.000219431	0.000235708	1	0	T	25962006	T	T	25962006	2	4	170	1	0	0	0	0	0	0	0	1	1118	1103	39	3		3	ATP10A	15	25962006	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1040317	25962006	76569386	222	32058											
RYR3	6263	broad.mit.edu	37	chr15	34021144	34021144	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttcttggaccgcgtttatGgcattaaggatcaaactttt	9	16	9	7	2	2	0	1	0	1	0	2	2	2	2	1	3	1	3	1	3	3	7			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr15:34021144G>T	uc001zhi.2	+	47	7190	c.7120G>T	c.(7120-7122)GGC>TGC	p.G2374C	RYR3_uc010bar.2_Missense_Mutation_p.G2374C	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2374	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCGCGTTTATGGCATTAAGGA	0.463													9	12					1.12685e-05	1.24815e-05	1	0	T	34021144	T	T	34021144	3	4	170	1	0	0	0	0	1	0	0	0	13835	1348	47	4	7306	4	RYR3	15	34021144	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	8059138	34021144	68510248	223	32059											
IVD	3712	broad.mit.edu	37	chr15	40710403	40710403	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgtatgagataggggctGggaccagcgaggtgaggcgg	9	6	20	6	2	0	2	0	2	0	1	0	5	0	3	1	6	2	3	1	6	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr15:40710403G>T	uc001zls.3	+	12	1556	c.1222G>T	c.(1222-1224)GGG>TGG	p.G408W	IVD_uc001zlq.2_Missense_Mutation_p.G378W|IVD_uc001zlr.2_Missense_Mutation_p.G111W	NM_002225	NP_002216	P26440	IVD_HUMAN	isovaleryl Coenzyme A dehydrogenase isoform 1	405	Substrate binding.				leucine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|isovaleryl-CoA dehydrogenase activity			ovary(1)	1		all_cancers(109;1.19e-18)|all_epithelial(112;1.52e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.65e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0808)		GATAGGGGCTGGGACCAGCGA	0.567													14	53					9.16793e-09	1.09959e-08	1	0	T	40710403	T	T	40710403	3	4	170	1	0	0	0	0	1	0	0	0	7967	1348	47	4	1268	4	IVD	15	40710403	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	6689259	40710403	61820989	224	32060											
TP53BP1	7158	broad.mit.edu	37	chr15	43784507	43784507	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggattttctttgtgcgtcTggagattaggaaggtgtcga	8	14	14	5	2	2	1	0	0	2	1	3	5	2	3	0	4	1	0	0	4	2	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr15:43784507T>C	uc001zrs.2	-	2	300	c.152A>G	c.(151-153)CAG>CGG	p.Q51R	TP53BP1_uc010udp.1_Missense_Mutation_p.Q51R|TP53BP1_uc001zrq.3_Missense_Mutation_p.Q56R|TP53BP1_uc001zrr.3_Missense_Mutation_p.Q56R|TP53BP1_uc010udq.1_Missense_Mutation_p.Q56R	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	51					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TTTGTGCGTCTGGAGATTAGG	0.393								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					3	96					0	0	0	0	C	43784507	C	C	43784507	3	2	170	1	0	0	0	0	1	0	0	0	16450	1580	55	5	5874	5	TP53BP1	15	43784507	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	3074104	43784507	58746885	225	32061											
C15orf43	145645	broad.mit.edu	37	chr15	45253759	45253759	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagttttatttgggaacaaGaccaacattttctgatagaa	14	14	8	5	0	1	3	0	1	1	2	1	4	1	4	1	1	2	2	1	1	7	7			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr15:45253759G>C	uc001zuk.2	+	4	342	c.325G>C	c.(325-327)GAC>CAC	p.D109H		NM_152448	NP_689661	Q8NHR7	CO043_HUMAN	hypothetical protein LOC145645	109											0		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)		TTGGGAACAAGACCAACATTT	0.284													3	63					0	0	0	0	C	45253759	C	C	45253759	3	2	170	1	0	0	0	0	1	0	0	0	1803	942	33	2	339	2	C15orf43	15	45253759	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1469252	45253759	57277633	226	32062											
FBN1	2200	broad.mit.edu	37	chr15	48720627	48720627	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgggtgttgaggcagcgccCattctcacagatccctggct	7	9	12	13	2	1	2	1	1	1	1	3	2	2	2	2	3	1	3	2	3	0	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr15:48720627C>A	uc001zwx.1	-	57	7241	c.6913G>T	c.(6913-6915)GGG>TGG	p.G2305W	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2305	EGF-like 40; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGGCAGCGCCCATTCTCACAG	0.488													18	15					3.32936e-07	3.84006e-07	1	0	A	48720627	A	A	48720627	3	1	170	1	0	0	0	0	1	0	0	0	5734	594	21	4	1742	4	FBN1	15	48720627	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	3466868	48720627	53810765	227	32063											
C15orf33	196951	broad.mit.edu	37	chr15	49880219	49880219	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catagataccataccattatCttttttttcttatggtactt	10	20	3	8	0	2	1	0	0	2	1	2	1	2	1	2	1	3	1	2	1	6	11			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr15:49880219C>T	uc001zxl.2	-	5	693	c.399G>A	c.(397-399)AAG>AAA	p.K133K	C15orf33_uc001zxm.2_Silent_p.K133K	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	133										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		ATACCATTATCTTTTTTTTCT	0.269													9	22					0	0	0	0	T	49880219	T	T	49880219	2	4	170	1	0	0	0	0	0	0	0	1	1797	912	32	2		2	C15orf33	15	49880219	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	1159592	49880219	52651173	228	32064											
ZNF609	23060	broad.mit.edu	37	chr15	64791535	64791535	+	5'Flank	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactgaccaatgtggcaggTctgagaacatagctgaagct	12	9	12	8	0	1	3	0	3	1	1	1	4	1	3	1	2	4	4	1	2	5	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr15:64791535T>G	uc002ann.2	+						ZNF609_uc010bgy.2_5'UTR	NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609							nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ATGTGGCAGGTCTGAGAACAT	0.448													5	10					0	0	0	0	G	64791535	G	G	64791535	1	3	170	0	1	0	0	0	0	0	0	0	18102	1682	58	5		5	ZNF609	15	64791535	5'Flank	SNP	T	TCGA-CV-5432-01A-02D-1683-08	14911316	64791535	37739857	229	32065											
IL16	3603	broad.mit.edu	37	chr15	81517986	81517986	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatctagcactggcctcggaGgctgctcaactccaagcagc	9	7	11	14	1	2	0	1	0	1	0	4	2	3	1	2	3	5	4	2	3	3	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr15:81517986G>T	uc002bgh.3	+	2	622	c.246G>T	c.(244-246)GAG>GAT	p.E82D	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.E82D|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.E124D|IL16_uc002bgg.2_Missense_Mutation_p.E82D	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	82					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						TGGCCTCGGAGGCTGCTCAAC	0.567													6	25					8.12818e-05	8.82811e-05	1	0	T	81517986	T	T	81517986	3	4	170	1	0	0	0	0	1	0	0	0	7672	991	35	4	248	4	IL16	15	81517986	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	16726451	81517986	21013406	230	32066											
SRRM2	23524	broad.mit.edu	37	chr16	2811881	2811881	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccagctccagggtcccaccGagagatttcttcttctccca	7	11	7	16	1	3	1	0	0	3	1	7	3	6	1	5	1	1	1	5	1	0	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr16:2811881G>A	uc002crk.2	+	11	1901	c.1352G>A	c.(1351-1353)CGA>CAA	p.R451Q	SRRM2_uc002crj.1_Missense_Mutation_p.R355Q|SRRM2_uc002crl.1_Missense_Mutation_p.R451Q|SRRM2_uc010bsu.1_Missense_Mutation_p.R355Q	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	451	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GGGTCCCACCGAGAGATTTCT	0.542													4	134					0	0	0	0	A	2811881	A	A	2811881	3	1	170	1	0	0	0	0	1	0	0	0	15235	1058	37	1	1390	1	SRRM2	16	2811881	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08		2811881	87542872	231	32067											
CREBBP	1387	broad.mit.edu	37	chr16	3781826	3781826	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcttctgggacaggtcattgGacacgttgggcatgctgggc	6	10	16	9	1	2	0	1	0	1	0	2	2	2	2	0	5	1	4	0	5	0	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr16:3781826G>A	uc002cvv.2	-	29	5045	c.4841C>T	c.(4840-4842)TCC>TTC	p.S1614F	CREBBP_uc002cvw.2_Missense_Mutation_p.S1576F	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1614	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CAGGTCATTGGACACGTTGGG	0.383			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				19	52					0	0	0	0	A	3781826	A	A	3781826	3	1	170	1	0	0	0	0	1	0	0	0	3876	1174	41	2	2499	2	CREBBP	16	3781826	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	969945	3781826	86572927	232	32068											
CIITA	4261	broad.mit.edu	37	chr16	10995377	10995377	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttttctctgcagccttccCagaggagcttccggcagacc	6	11	10	14	1	1	2	0	0	1	2	4	3	3	3	4	2	3	4	4	2	0	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr16:10995377C>A	uc002dai.3	+	6	576	c.443C>A	c.(442-444)CCA>CAA	p.P148Q	CIITA_uc002daj.3_Missense_Mutation_p.P149Q|CIITA_uc002dak.3_Missense_Mutation_p.P148Q|CIITA_uc002dag.2_Missense_Mutation_p.P148Q|CIITA_uc002dah.2_Missense_Mutation_p.P149Q|CIITA_uc010bup.1_Missense_Mutation_p.P148Q	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	148					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						GCAGCCTTCCCAGAGGAGCTT	0.602			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								12	20					6.72482e-11	8.34732e-11	1	0	A	10995377	A	A	10995377	3	1	170	1	0	0	0	0	1	0	0	0	3443	594	21	4	465	4	CIITA	16	10995377	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	7213551	10995377	79359376	233	32069											
MARVELD3	91862	broad.mit.edu	37	chr16	71668181	71668181	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttccacagggggctacacGggcatcaccagcttgggggg	8	6	16	11	1	1	0	1	0	0	0	2	0	2	0	2	6	2	4	2	6	1	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr16:71668181G>A	uc002fat.2	+	3	744	c.681G>A	c.(679-681)ACG>ACA	p.T227T	MARVELD3_uc002fau.2_Intron|MARVELD3_uc010cge.2_Intron	NM_052858	NP_443090	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 2	227	MARVEL.|Helical; (Potential).					integral to membrane				skin(1)	1		Ovarian(137;0.125)				GGGGCTACACGGGCATCACCA	0.557													4	134					0	0	0	0	A	71668181	A	A	71668181	2	1	170	1	0	0	0	0	0	0	0	1	9372	1103	39	1		1	MARVELD3	16	71668181	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	60672804	71668181	18686572	234	32070											
CNTNAP4	85445	broad.mit.edu	37	chr16	76389225	76389225	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaataaaaggagctggtggCtggtctccacttgtgtctaa	10	13	11	7	0	2	0	0	0	2	0	3	1	2	1	1	4	1	2	1	4	4	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr16:76389225C>A	uc002feu.1	+	5	592	c.207C>A	c.(205-207)GGC>GGA	p.G69G	CNTNAP4_uc002fev.1_Translation_Start_Site|CNTNAP4_uc010chb.1_Silent_p.G44G|CNTNAP4_uc002fex.1_Silent_p.G72G|CNTNAP4_uc002few.2_Silent_p.G44G	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	69	Extracellular (Potential).|F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GAGCTGGTGGCTGGTCTCCAC	0.413													6	34					5.4927e-09	6.62854e-09	1	0	A	76389225	A	A	76389225	2	1	170	1	0	0	0	0	0	0	0	1	3664	784	28	4		4	CNTNAP4	16	76389225	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	4721044	76389225	13965528	235	32071											
PLCG2	5336	broad.mit.edu	37	chr16	81942171	81942171	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcgggagagcgagaccttcCccaatgactacaccctgtcc	9	8	9	15	2	0	3	0	1	0	2	3	5	2	3	5	1	2	0	5	1	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr16:81942171C>G	uc002fgt.2	+	17	1860	c.1708C>G	c.(1708-1710)CCC>GCC	p.P570A	PLCG2_uc010chg.1_Missense_Mutation_p.P570A	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	570	SH2 1.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						CGAGACCTTCCCCAATGACTA	0.592													5	6					0	0	0	0	G	81942171	G	G	81942171	3	3	170	1	0	0	0	0	1	0	0	0	12091	623	22	4	1770	4	PLCG2	16	81942171	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	5552946	81942171	8412582	236	32072											
CAMTA2	23125	broad.mit.edu	37	chr17	4883214	4883214	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcaggtgagggtgggggtGagggagggggtgaaggtatg	7	6	27	1	0	0	3	0	3	0	0	0	4	0	4	0	9	0	2	0	9	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:4883214G>T	uc002gah.1	-	9	1511	c.1403C>A	c.(1402-1404)TCA>TAA	p.S468*	CAMTA2_uc010cku.1_Nonsense_Mutation_p.S491*|CAMTA2_uc002gag.1_Nonsense_Mutation_p.S467*|CAMTA2_uc002gai.1_Nonsense_Mutation_p.S470*|CAMTA2_uc010ckv.1_Nonsense_Mutation_p.S115*|CAMTA2_uc010vsu.1_Nonsense_Mutation_p.S281*	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	468					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						gggtgggggtgagggaggggg	0.463													24	75					4.26978e-12	5.40286e-12	1	0	T	4883214	T	T	4883214	4	4	170	1	0	0	0	0	0	1	0	0	2626	1294	45	2	2315	2	CAMTA2	17	4883214	Nonsense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08		4883214	76311996	237	32073											
PLSCR3	57048	broad.mit.edu	37	chr17	7297016	7297016	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaggcgaggggaagagggcGaagccgggagctggggcagg	9	1	23	8	3	0	1	0	0	0	1	0	5	0	3	2	8	2	2	2	8	2	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:7297016G>A	uc002ggm.1	-	3	356	c.147C>T	c.(145-147)TTC>TTT	p.F49F	PLSCR3_uc002ggl.2_Silent_p.F49F|PLSCR3_uc002ggq.1_5'UTR|PLSCR3_uc002ggn.1_Silent_p.F49F|PLSCR3_uc002ggo.1_Silent_p.F49F|PLSCR3_uc002ggp.1_5'UTR|PLSCR3_uc002ggr.1_Silent_p.F49F|PLSCR3_uc010cmg.1_Silent_p.F49F	NM_020360	NP_065093	Q9NRY6	PLS3_HUMAN	phospholipid scramblase 3	49	Cytoplasmic (By similarity).			F->A: Reduces interaction with PDCD6. Abolishes interaction with PDCD6; when associated with A-52.|F->W: No effect on the interaction with PDCD6.|F->Y,L: Reduces interaction with PDCD6.	phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|calcium-dependent protein binding|phospholipid scramblase activity|SH3 domain binding				0		Prostate(122;0.173)				GGAAGAGGGCGAAGCCGGGAG	0.711													5	8					0	0	0	0	A	7297016	A	A	7297016	2	1	170	1	0	0	0	0	0	0	0	1	12166	1049	37	1		1	PLSCR3	17	7297016	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	2413802	7297016	73898194	238	32074											
TP53	7157	broad.mit.edu	37	chr17	7577018	7577018	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cttcttgtcctgcttgcttaCctcgcttagtgctccctggg	2	16	9	14	1	1	0	0	0	1	0	4	0	3	0	3	1	4	4	3	1	2	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:7577018C>A	uc002gim.2	-	8	1113	c.919_splice	c.e8+1	p.A307_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.A307_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.A175_splice|TP53_uc010cng.1_Splice_Site_p.A175_splice|TP53_uc002gii.1_Splice_Site_p.A175_splice|TP53_uc010cnh.1_Splice_Site_p.A307_splice|TP53_uc010cni.1_Splice_Site_p.A307_splice|TP53_uc002gij.2_Splice_Site_p.A307_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(21)|p.0?(7)|p.A307fs*34(1)|p.L308fs*31(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTGCTTACCTCGCTTAGT	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			69	19					3.41413e-29	4.88984e-29	1	0	A	7577018	A	A	7577018	5	1	170	1	0	0	0	0	0	0	1	0	16448	521	18	4	366	4	TP53	17	7577018	Splice_Site	SNP	C	TCGA-CV-5432-01A-02D-1683-08	280002	7577018	73618192	239	32075											
MYH13	8735	broad.mit.edu	37	chr17	10248871	10248871	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgctggttgatgcgggtGaccatccacaggaacatctt	9	10	12	10	1	1	2	0	2	1	0	2	3	2	3	2	3	4	3	2	3	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:10248871G>A	uc002gmk.1	-	14	1416	c.1326C>T	c.(1324-1326)GTC>GTT	p.V442V	MYH13_uc010vvf.1_Silent_p.V117V	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	442	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGATGCGGGTGACCATCCACA	0.527													46	78					0	0	0	0	A	10248871	A	A	10248871	2	1	170	1	0	0	0	0	0	0	0	1	10085	1277	45	2		2	MYH13	17	10248871	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	2671853	10248871	70946339	240	32076											
DNAH9	1770	broad.mit.edu	37	chr17	11543609	11543609	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctccccggtgcacaagaaCatgcccaccgtggctggcgg	7	7	12	15	3	1	1	0	0	1	1	2	1	1	1	4	4	3	2	4	4	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:11543609C>T	uc002gne.2	+	10	1877	c.1809C>T	c.(1807-1809)AAC>AAT	p.N603N		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	603	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGCACAAGAACATGCCCACCG	0.602													136	47					0	0	0	0	T	11543609	T	T	11543609	2	4	170	1	0	0	0	0	0	0	0	1	4630	477	17	4		4	DNAH9	17	11543609	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	1294738	11543609	69651601	241	32077											
TEKT3	64518	broad.mit.edu	37	chr17	15215750	15215750	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcccgttcactctgggagcgGagaatattgtcatctgtaaa	10	11	11	9	2	4	1	2	0	2	1	4	3	4	2	1	2	1	2	1	2	4	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:15215750G>C	uc002gon.2	-	7	1114	c.927C>G	c.(925-927)CTC>CTG	p.L309L		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	309					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		TCTGGGAGCGGAGAATATTGT	0.463													6	62					0	0	0	0	C	15215750	C	C	15215750	2	2	170	1	0	0	0	0	0	0	0	1	15820	1161	41	2		2	TEKT3	17	15215750	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	3672141	15215750	65979460	242	32078											
LRRC48	83450	broad.mit.edu	37	chr17	17910396	17910396	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaagctcctggagatctctAtcagcaccctggagaagatt	12	9	10	10	0	2	4	1	0	1	4	4	6	3	4	2	2	2	2	2	2	3	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:17910396A>G	uc010vxd.1	+	13	1640	c.1261A>G	c.(1261-1263)ATC>GTC	p.I421V	LRRC48_uc002gsa.2_Missense_Mutation_p.I421V|LRRC48_uc010vxc.1_Missense_Mutation_p.I421V|LRRC48_uc002gsb.2_Missense_Mutation_p.I421V	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	421						cytoplasm				pancreas(1)	1	all_neural(463;0.228)					GGAGATCTCTATCAGCACCCT	0.562													10	14					0	0	0	0	G	17910396	G	G	17910396	3	3	170	1	0	0	0	0	1	0	0	0	9055	449	16	5	1299	5	LRRC48	17	17910396	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	2694646	17910396	63284814	243	32079											
SPAG5	10615	broad.mit.edu	37	chr17	26906469	26906469	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctcagtagtcataatactCatttctgccaggctctcctc	9	13	6	13	0	5	0	3	0	2	0	7	0	5	0	2	1	3	3	2	1	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:26906469C>A	uc002hbq.2	-	18	3011	c.2919G>T	c.(2917-2919)ATG>ATT	p.M973I	ALDOC_uc002hbp.2_5'Flank|ALDOC_uc010cro.2_5'Flank	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	973					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			central_nervous_system(1)	1	Lung NSC(42;0.00431)					TCATAATACTCATTTCTGCCA	0.488													59	69					5.86059e-21	8.09714e-21	1	0	A	26906469	A	A	26906469	3	1	170	1	0	0	0	0	1	0	0	0	15047	826	29	2	690	2	SPAG5	17	26906469	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	8996073	26906469	54288741	244	32080											
SOCS7	30837	broad.mit.edu	37	chr17	36520668	36520668	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttgtggatgtggacatttCtcagcggggcctgacctctc	5	12	13	11	1	2	1	1	1	2	0	4	3	2	3	2	4	1	1	2	4	0	2	rs77546775		TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:36520668C>G	uc002hqa.2	+	3	1010	c.887C>G	c.(886-888)TCT>TGT	p.S296C	SOCS7_uc010cvl.2_Missense_Mutation_p.S296C|SOCS7_uc002hqb.2_RNA	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	296	Mediates interaction with SORBS3.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					GTGGACATTTCTCAGCGGGGC	0.542													12	63					0	0	0	0	G	36520668	G	G	36520668	3	3	170	1	0	0	0	0	1	0	0	0	14983	913	32	2	897	2	SOCS7	17	36520668	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	9614199	36520668	44674542	245	32081											
CDK12	51755	broad.mit.edu	37	chr17	37687138	37687138	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgatgggcctgaaacagggTtcagtgccattgacactgat	10	10	12	9	0	1	4	1	4	0	0	1	4	1	4	2	2	2	1	2	2	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:37687138T>C	uc010cvv.2	+	14	4628	c.4042T>C	c.(4042-4044)TTC>CTC	p.F1348L	CDK12_uc002hrw.3_Missense_Mutation_p.F1339L	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	1348					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						TGAAACAGGGTTCAGTGCCAT	0.542										TCGA Ovarian(9;0.13)			10	222					0	0	0	0	C	37687138	C	C	37687138	3	2	170	1	0	0	0	0	1	0	0	0	3143	1725	60	5	4096	5	CDK12	17	37687138	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	1166470	37687138	43508072	246	32082											
KRTAP1-3	81850	broad.mit.edu	37	chr17	39190615	39190615	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcagcagactgggcggcaGcaggactgtccacagtagga	11	4	15	11	1	0	1	0	0	0	1	1	3	1	3	1	4	3	5	1	4	1	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:39190615G>A	uc002hvv.2	-	1	493	c.459C>T	c.(457-459)TGC>TGT	p.C153C		NM_030966	NP_112228	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	163						extracellular region|keratin filament	structural constituent of epidermis				0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CTGGGCGGCAGCAGGACTGTC	0.577													11	32					0	0	0	0	A	39190615	A	A	39190615	2	1	170	1	0	0	0	0	0	0	0	1	8542	963	34	4		4	KRTAP1-3	17	39190615	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1503477	39190615	42004595	247	32083											
EZH1	2145	broad.mit.edu	37	chr17	40858050	40858050	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taagtccacgctggatgctgCagtttttacaggaaaccacc	11	10	9	11	1	0	0	0	0	0	0	1	2	1	2	3	2	4	4	3	2	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:40858050C>A	uc002iaz.2	-	16	1959	c.1814G>T	c.(1813-1815)TGC>TTC	p.C605F	EZH1_uc002iba.2_Missense_Mutation_p.C596F|EZH1_uc010wgt.1_Missense_Mutation_p.C535F|EZH1_uc010wgu.1_Missense_Mutation_p.C611F|EZH1_uc010wgv.1_Missense_Mutation_p.C565F|EZH1_uc010wgw.1_Missense_Mutation_p.C466F|EZH1_uc010cyp.2_Missense_Mutation_p.C506F|EZH1_uc010cyq.2_Missense_Mutation_p.C522F|EZH1_uc010cyo.1_Missense_Mutation_p.C268F	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	605	Cys-rich.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		CTGGATGCTGCAGTTTTTACA	0.537													6	12					0.00116845	0.00121506	1	0	A	40858050	A	A	40858050	3	1	170	1	0	0	0	0	1	0	0	0	5358	710	25	4	453	4	EZH1	17	40858050	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	1667435	40858050	40337160	248	32084											
EPN3	55040	broad.mit.edu	37	chr17	48618421	48618421	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggagacctccgacacacCtggtaagaagagggccagag	12	4	13	12	1	0	4	0	0	0	4	1	6	1	4	5	3	0	1	5	3	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:48618421C>G	uc002ira.3	+	7	1682	c.1247C>G	c.(1246-1248)CCT>CGT	p.P416R	SPATA20_uc002irc.2_5'Flank|EPN3_uc010wms.1_Missense_Mutation_p.P444R|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.P389R	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	416						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			TCCGACACACCTGGTAAGAAG	0.627													4	33					0	0	0	0	G	48618421	G	G	48618421	3	3	170	1	0	0	0	0	1	0	0	0	5211	681	24	4	1269	4	EPN3	17	48618421	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	7760371	48618421	32576789	249	32085											
ABCA6	23460	broad.mit.edu	37	chr17	67124870	67124870	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcccagacatccccaaaagaGggtaaggagaaacacaacca	18	3	8	12	0	0	3	0	0	0	3	2	4	2	3	4	2	2	1	4	2	5	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:67124870G>T	uc002jhw.1	-	8	1184	c.1009C>A	c.(1009-1011)CTC>ATC	p.L337I		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	337	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					CCCCAAAAGAGGGTAAGGAGA	0.423													11	63					2.80697e-09	3.41909e-09	1	0	T	67124870	T	T	67124870	3	4	170	1	0	0	0	0	1	0	0	0	36	1000	35	4	3972	4	ABCA6	17	67124870	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	18506449	67124870	14070340	250	32086											
C17orf77	146723	broad.mit.edu	37	chr17	72588683	72588683	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acccaagcattgaggagctgCgggatctactgcctggagga	10	7	14	10	1	1	1	0	1	1	0	1	5	1	5	2	4	5	2	2	4	2	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:72588683C>T	uc002jla.1	+	3	860	c.498C>T	c.(496-498)TGC>TGT	p.C166C	CD300LD_uc002jkz.2_5'Flank	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	166						extracellular region					0						TGAGGAGCTGCGGGATCTACT	0.587													8	29					0	0	0	0	T	72588683	T	T	72588683	2	4	170	1	0	0	0	0	0	0	0	1	1890	776	27	1		1	C17orf77	17	72588683	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	5463813	72588683	8606527	251	32087											
SLC26A11	284129	broad.mit.edu	37	chr17	78219976	78219976	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agccgtgaacgctcagtcggGggtgtgcaccccggcggggg	5	5	19	12	5	1	1	1	1	0	0	2	1	1	1	3	5	3	2	3	5	1	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr17:78219976G>T	uc002jyb.1	+	12	1390	c.1121G>T	c.(1120-1122)GGG>GTG	p.G374V	SLC26A11_uc002jyc.1_Missense_Mutation_p.G374V|SLC26A11_uc002jyd.1_Missense_Mutation_p.G374V|SLC26A11_uc010dhv.1_Missense_Mutation_p.G374V	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	374	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GCTCAGTCGGGGGTGTGCACC	0.667													22	102					3.6726e-16	4.91777e-16	1	0	T	78219976	T	T	78219976	3	4	170	1	0	0	0	0	1	0	0	0	14580	1232	43	4	1159	4	SLC26A11	17	78219976	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	5631293	78219976	2975234	252	32088											
MYOM1	8736	broad.mit.edu	37	chr18	3215034	3215034	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaggaggaggcggacgccCgacggaaggcctcggactcc	8	2	19	12	5	0	0	0	0	0	0	2	7	1	6	3	8	0	0	3	8	1	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr18:3215034C>T	uc002klp.2	-	2	522	c.188G>A	c.(187-189)CGG>CAG	p.R63Q	MYOM1_uc002klq.2_Missense_Mutation_p.R63Q	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	63						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GGCGGACGCCCGACGGAAGGC	0.687													9	38					0	0	0	0	T	3215034	T	T	3215034	3	4	170	1	0	0	0	0	1	0	0	0	10144	652	23	1	5017	1	MYOM1	18	3215034	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08		3215034	74862214	253	32089											
ZFP161	7541	broad.mit.edu	37	chr18	5291107	5291107	+	Missense_Mutation	SNP	T	A	A																															acttgtgtttgaaggctttgTcacacatgtggcacgcaaac																										TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr18:5291107T>A	uc002kmq.2	-	4	1261	c.1100A>T	c.(1099-1101)GAC>GTC	p.D367V	ZFP161_uc002kmr.2_Missense_Mutation_p.D367V|ZFP161_uc010dkp.2_Missense_Mutation_p.D367V	NM_003409	NP_003400	O43829	ZF161_HUMAN	zinc finger protein 161 homolog	367	C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAAGGCTTTGTCACACATGTG	0.468													27	100					0	0	0	0	A	5291107	A	A	5291107	3	1	170	1	0	0	0	0	1	0	0	0	17707	1667	58	5	253	5	ZFP161	18	5291107	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	2076073	5291107	72786141	254	32090	63	2									
ZFP161	7541	broad.mit.edu	37	chr18	5291112	5291112	+	Missense_Mutation	SNP	C	T	T																															tgtttgaaggctttgtcacaCatgtggcacgcaaacggtct																										TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr18:5291112C>T	uc002kmq.2	-	4	1256	c.1095G>A	c.(1093-1095)ATG>ATA	p.M365I	ZFP161_uc002kmr.2_Missense_Mutation_p.M365I|ZFP161_uc010dkp.2_Missense_Mutation_p.M365I	NM_003409	NP_003400	O43829	ZF161_HUMAN	zinc finger protein 161 homolog	365	C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTTTGTCACACATGTGGCACG	0.463													27	99					0	0	0	0	T	5291112	T	T	5291112	3	4	170	1	0	0	0	0	1	0	0	0	17707	478	17	4	258	4	ZFP161	18	5291112	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	5	5291112	72786136	255	32091	63	2									
NAPG	8774	broad.mit.edu	37	chr18	10540342	10540342	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcagaatgaagaacgcttacGacaggcagttgaattactag	15	9	10	7	2	1	4	1	2	0	2	1	5	1	4	0	1	3	3	0	1	7	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr18:10540342G>C	uc002kon.2	+	8	679	c.452G>C	c.(451-453)CGA>CCA	p.R151P	NAPG_uc010wzr.1_Missense_Mutation_p.R69P|NAPG_uc002koo.2_Missense_Mutation_p.R64P|NAPG_uc002kop.2_Missense_Mutation_p.R64P	NM_003826	NP_003817	Q99747	SNAG_HUMAN	N-ethylmaleimide-sensitive factor attachment	151					cellular membrane fusion|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein complex assembly|protein stabilization	membrane|membrane fraction|mitochondrion	protein binding				0						GAACGCTTACGACAGGCAGTT	0.338													26	38					0	0	0	0	C	10540342	C	C	10540342	3	2	170	1	0	0	0	0	1	0	0	0	10217	1058	37	3	482	3	NAPG	18	10540342	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	5249230	10540342	67536906	256	32092											
ANKRD30B	374860	broad.mit.edu	37	chr18	14752641	14752641	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagacagaaagtgccagcttAatgtccttgatggcgaaggg	12	9	13	7	1	0	3	0	1	0	2	1	4	1	3	2	2	2	1	2	2	4	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr18:14752641A>C	uc010dlo.2	+	2	478	c.298A>C	c.(298-300)AAT>CAT	p.N100H	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	100	ANK 1.									ovary(1)|skin(1)	2						GTGCCAGCTTAATGTCCTTGA	0.433													13	13					0	0	0	0	C	14752641	C	C	14752641	3	2	170	1	0	0	0	0	1	0	0	0	659	362	13	5	304	5	ANKRD30B	18	14752641	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	4212299	14752641	63324607	257	32093											
PSMA8	143471	broad.mit.edu	37	chr18	23731942	23731942	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgcttcatagcaactttaaAgcaggtaagctaatattcta	14	13	6	8	1	2	0	1	0	1	0	3	0	2	0	0	1	4	5	0	1	8	9			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr18:23731942A>G	uc002kvq.2	+	3	482	c.368A>G	c.(367-369)AAG>AGG	p.K123R	PSMA8_uc002kvo.2_Missense_Mutation_p.K79R|PSMA8_uc002kvp.2_Missense_Mutation_p.K117R|PSMA8_uc002kvr.2_Missense_Mutation_p.K91R	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1	123					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)			GCAACTTTAAAGCAGGTAAGC	0.388													11	76					0	0	0	0	G	23731942	G	G	23731942	3	3	170	1	0	0	0	0	1	0	0	0	12735	72	3	5	378	5	PSMA8	18	23731942	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	8979301	23731942	54345306	258	32094											
DSG3	1830	broad.mit.edu	37	chr18	29054239	29054239	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcaggattcggagcagccActggagttggcatctgttcc	7	11	12	11	1	2	0	1	0	1	0	4	3	3	3	2	4	2	4	2	4	0	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr18:29054239A>T	uc002kws.2	+	15	2366	c.2257A>T	c.(2257-2259)ACT>TCT	p.T753S	DSG3_uc002kwt.2_Missense_Mutation_p.T35S	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	753	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CGGAGCAGCCACTGGAGTTGG	0.537													47	47					0	0	0	0	T	29054239	T	T	29054239	3	4	170	1	0	0	0	0	1	0	0	0	4800	159	6	5	2315	5	DSG3	18	29054239	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	5322297	29054239	49023009	259	32095											
KIAA1328	57536	broad.mit.edu	37	chr18	34415329	34415329	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaaggcacaggagattcagTagatgaacaggttagtattt	16	10	11	4	0	1	3	1	1	0	2	1	4	1	3	0	3	1	4	0	3	6	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr18:34415329T>C	uc002kzz.2	+	3	249	c.227T>C	c.(226-228)GTA>GCA	p.V76A		NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	76				V -> A (in Ref. 3; CAD89947).						central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		GGAGATTCAGTAGATGAACAG	0.393													9	195					0	0	0	0	C	34415329	C	C	34415329	3	2	170	1	0	0	0	0	1	0	0	0	8264	1638	57	5	237	5	KIAA1328	18	34415329	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	5361090	34415329	43661919	260	32096											
KIAA1328	57536	broad.mit.edu	37	chr18	34647234	34647234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcgtgttcatgacagccatCctacaaacatgacccctcaa	13	9	5	14	1	2	2	2	2	0	0	4	2	3	2	4	0	3	1	4	0	3	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr18:34647234C>T	uc002kzz.2	+	7	980	c.958C>T	c.(958-960)CCT>TCT	p.P320S	KIAA1328_uc002lab.2_Missense_Mutation_p.P36S|KIAA1328_uc002lac.1_Missense_Mutation_p.P143S|KIAA1328_uc010dnc.1_RNA|KIAA1328_uc002lad.2_Missense_Mutation_p.P36S	NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	320										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		TGACAGCCATCCTACAAACAT	0.473													12	65					0	0	0	0	T	34647234	T	T	34647234	3	4	170	1	0	0	0	0	1	0	0	0	8264	855	30	2	984	2	KIAA1328	18	34647234	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	231905	34647234	43430014	261	32097											
SYT4	6860	broad.mit.edu	37	chr18	40853629	40853629	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagagaggaattagaacttcCccaatgatatcatctcttga	14	11	8	8	0	2	4	1	2	1	2	4	7	3	5	2	1	1	0	2	1	5	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr18:40853629C>T	uc002law.2	-	2	1134	c.765G>A	c.(763-765)GGG>GGA	p.G255G	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Silent_p.G237G|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	255	Phospholipid binding (Probable).|C2 1.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TTAGAACTTCCCCAATGATAT	0.353													23	12					0	0	0	0	T	40853629	T	T	40853629	2	4	170	1	0	0	0	0	0	0	0	1	15542	610	22	4		4	SYT4	18	40853629	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	6206395	40853629	37223619	262	32098											
APBA3	9546	broad.mit.edu	37	chr19	3752611	3752611	+	Frame_Shift_Del	DEL	C	-	-																															gcccccgagcgctcagcaggCcccccgtgcagcaggttggc																										TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:3752611delC	uc002lyp.1	-	8	1467	c.1290delG	c.(1288-1290)GGGfs	p.G430fs	APBA3_uc002lyo.1_Frame_Shift_Del_p.G188fs	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	430	PDZ 1.				intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCAGCAGGCCCCCCGTGCA	0.746													---	---	---								-	3752611	-	-	3752611	7	5	170	1	0	1	0	1	0	0	0	0	758	726	26	0	453	0	APBA3	19	3752611	Frame_Shift_Del	DEL	C	TCGA-CV-5432-01A-02D-1683-08		3752611	55376372	263	32099											
RFX2	5990	broad.mit.edu	37	chr19	6008155	6008155	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccagctgcagggccttgaCgtcgtgcagtgtgacgccgt	6	8	14	13	4	0	2	0	2	0	0	1	2	0	2	3	1	3	3	3	1	0	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:6008155C>T	uc002meb.2	-	10	1365	c.1096G>A	c.(1096-1098)GTC>ATC	p.V366I	RFX2_uc002mec.2_Missense_Mutation_p.V341I|RFX2_uc002med.1_Missense_Mutation_p.R35H	NM_000635	NP_000626	P48378	RFX2_HUMAN	regulatory factor X2 isoform a	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|ovary(1)|skin(1)	6						AGGGCCTTGACGTCGTGCAGT	0.682													4	3					0	0	0	0	T	6008155	T	T	6008155	3	4	170	1	0	0	0	0	1	0	0	0	13328	536	19	1	1111	1	RFX2	19	6008155	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	2255544	6008155	53120828	264	32100											
C19orf59	199675	broad.mit.edu	37	chr19	7743860	7743860	+	Frame_Shift_Del	DEL	A	-	-																															aaatcttggaggtgctgcagAaaatgccacgtaagttggcg																										TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:7743860delA	uc002mhh.1	+	6	563	c.538delA	c.(538-540)AAAfs	p.K180fs	TRAPPC5_uc002mhi.1_5'Flank|TRAPPC5_uc002mhj.1_5'Flank|TRAPPC5_uc002mhk.1_5'Flank	NM_174918	NP_777578	Q8IX19	MCEM1_HUMAN	mast cell-expressed membrane protein 1	180	Extracellular (Potential).					integral to membrane				skin(1)	1						GGTGCTGCAGAAAATGCCACG	0.577											OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	7743860	-	-	7743860	7	5	170	1	0	1	0	1	0	0	0	0	1949	247	9	0	560	0	C19orf59	19	7743860	Frame_Shift_Del	DEL	A	TCGA-CV-5432-01A-02D-1683-08	1735705	7743860	51385123	265	32101											
MUC16	94025	broad.mit.edu	37	chr19	9062481	9062481	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgctgctcaaatttgaaGtggaactggttccaggttct	9	13	12	7	0	2	1	1	1	1	0	3	2	3	2	1	4	3	4	1	4	3	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:9062481G>T	uc002mkp.2	-	3	25169	c.24965C>A	c.(24964-24966)ACT>AAT	p.T8322N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8324	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAAATTTGAAGTGGAACTGGT	0.502													17	69					1.15088e-07	1.3554e-07	1	0	T	9062481	T	T	9062481	3	4	170	1	0	0	0	0	1	0	0	0	10026	1029	36	4	18886	4	MUC16	19	9062481	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1318621	9062481	50066502	266	32102											
COL5A3	50509	broad.mit.edu	37	chr19	10107183	10107183	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctttaaaggagccgcctgCaaactggaactgggaggaat	12	7	13	9	1	0	0	0	0	0	0	0	4	0	4	3	4	4	1	3	4	5	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:10107183C>A	uc002mmq.1	-	13	1434	c.1348G>T	c.(1348-1350)GCA>TCA	p.A450S		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	450	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GAGCCGCCTGCAAACTGGAAC	0.612													8	33					5.18039e-06	5.77075e-06	1	0	A	10107183	A	A	10107183	3	1	170	1	0	0	0	0	1	0	0	0	3713	710	25	4	4109	4	COL5A3	19	10107183	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	1044702	10107183	49021800	267	32103											
OR7A17	26333	broad.mit.edu	37	chr19	14991735	14991735	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatcatccaggatgccagaaCcaggagtccacagagccgag	14	4	11	12	1	1	2	1	0	0	2	3	5	3	4	5	2	3	0	5	2	2	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:14991735C>A	uc010xob.1	-	1	433	c.433G>T	c.(433-435)GTT>TTT	p.V145F		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					GATGCCAGAACCAGGAGTCCA	0.502													22	42					2.89027e-11	3.63375e-11	1	0	A	14991735	A	A	14991735	3	1	170	1	0	0	0	0	1	0	0	0	11269	507	18	4	498	4	OR7A17	19	14991735	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	4884552	14991735	44137248	268	32104											
ZNF536	9745	broad.mit.edu	37	chr19	30935052	30935052	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcgtgggcgtgtgcgcgagGagaaccgcctgctgcacgag	6	5	19	11	6	0	1	0	0	0	1	0	4	0	1	2	3	4	2	2	3	1	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:30935052G>A	uc002nsu.1	+	2	721	c.583G>A	c.(583-585)GAG>AAG	p.E195K	ZNF536_uc010edd.1_Missense_Mutation_p.E195K	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGTGCGCGAGGAGAACCGCCT	0.692													10	13					0	0	0	0	A	30935052	A	A	30935052	3	1	170	1	0	0	0	0	1	0	0	0	18041	1175	41	2	585	2	ZNF536	19	30935052	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	15943317	30935052	28193931	269	32105											
MEGF8	1954	broad.mit.edu	37	chr19	42863326	42863326	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggggcgctcggaccctgAcgagttcagcagcgacgttc	6	7	16	12	5	1	1	1	1	0	0	3	4	1	2	1	4	2	4	1	4	0	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:42863326A>T	uc002otl.3	+	30	5854	c.5219A>T	c.(5218-5220)GAC>GTC	p.D1740V	MEGF8_uc002otm.3_Missense_Mutation_p.D1348V	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1807	Extracellular (Potential).|Kelch 11.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				TCGGACCCTGACGAGTTCAGC	0.652													5	6					0	0	0	0	T	42863326	T	T	42863326	3	4	170	1	0	0	0	0	1	0	0	0	9516	275	10	5	5337	5	MEGF8	19	42863326	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	11928274	42863326	16265657	270	32106											
PSG6	5675	broad.mit.edu	37	chr19	43585341	43585341	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcggaaacttttggtggcTgggcttcaatcgtgacttgg	6	13	13	9	2	1	1	1	1	0	0	3	2	1	2	1	5	1	2	1	5	2	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:43585341T>A	uc002ovi.2	-	2	215	c.122A>T	c.(121-123)CAG>CTG	p.Q41L	PSG6_uc010xwk.1_Intron|PSG2_uc002ovr.2_Missense_Mutation_p.Q41L|PSG2_uc002ovq.3_Missense_Mutation_p.Q41L|PSG2_uc010eiq.1_Missense_Mutation_p.Q41L|PSG2_uc002ovs.3_Missense_Mutation_p.Q41L|PSG2_uc002ovt.3_Missense_Mutation_p.Q41L			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	41	Ig-like V-type.			K -> Q (in Ref. 3; CAA34957).	female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				TTTTGGTGGCTGGGCTTCAAT	0.478													44	79					0	0	0	0	A	43585341	A	A	43585341	3	1	170	1	0	0	0	0	1	0	0	0	12721	1580	55	5		5	PSG6	19	43585341	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	722015	43585341	15543642	271	32107											
ZFP112	7771	broad.mit.edu	37	chr19	44833219	44833219	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactattaaggtctaagctaTgactgaaggctttctcataa	13	14	7	7	0	2	2	1	2	2	0	3	2	2	2	0	2	2	2	0	2	7	7			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:44833219T>C	uc010ejj.2	-	5	1222	c.1109A>G	c.(1108-1110)CAT>CGT	p.H370R	ZFP112_uc002ozc.3_Missense_Mutation_p.H364R|ZFP112_uc010xwy.1_Missense_Mutation_p.H387R|ZFP112_uc010xwz.1_Missense_Mutation_p.H369R	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						GTCTAAGCTATGACTGAAGGC	0.383													14	37					0	0	0	0	C	44833219	C	C	44833219	3	2	170	1	0	0	0	0	1	0	0	0	17705	1464	51	5	1636	5	ZFP112	19	44833219	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	1247878	44833219	14295764	272	32108											
CCDC9	26093	broad.mit.edu	37	chr19	47761913	47761913	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaatgaggccctcatccggcGctaccaggtgccctagcccc	7	6	11	17	2	1	1	1	1	0	0	2	2	2	1	6	3	3	1	6	3	3	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:47761913G>T	uc010xym.1	+	3	308	c.101G>T	c.(100-102)CGC>CTC	p.R34L		NM_015603	NP_056418	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	34											0		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		CTCATCCGGCGCTACCAGGTG	0.502													10	27					9.70103e-10	1.1928e-09	1	0	T	47761913	T	T	47761913	3	4	170	1	0	0	0	0	1	0	0	0	2880	1087	38	3	107	3	CCDC9	19	47761913	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	2928694	47761913	11367070	273	32109											
PLA2G4C	8605	broad.mit.edu	37	chr19	48607867	48607867	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtggatccagagacccctgCgaggtacgtgacggcatcca	10	6	13	12	3	0	2	0	1	0	1	2	5	2	3	4	3	2	2	4	3	1	1	rs138956741	byFrequency	TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:48607867C>A	uc002phx.2	-	4	633	c.235G>T	c.(235-237)GCA>TCA	p.A79S	PLA2G4C_uc002phw.2_Missense_Mutation_p.A14S|PLA2G4C_uc010elr.2_Missense_Mutation_p.A79S|PLA2G4C_uc010xzd.1_Missense_Mutation_p.A89S|PLA2G4C_uc002phy.3_Missense_Mutation_p.A79S	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	79	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		GAGACCCCTGCGAGGTACGTG	0.468													14	40					7.05477e-17	9.51177e-17	1	0	A	48607867	A	A	48607867	3	1	170	1	0	0	0	0	1	0	0	0	12058	768	27	3	1450	3	PLA2G4C	19	48607867	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	845954	48607867	10521116	274	32110											
AP2A1	160	broad.mit.edu	37	chr19	50306435	50306435	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagtcaagtcagagttccGacagaacctgggtgtgtccc	9	8	13	11	2	2	2	2	0	0	2	4	4	4	3	3	2	1	1	3	2	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:50306435G>T	uc002ppn.2	+	18	2520	c.2309G>T	c.(2308-2310)CGA>CTA	p.R770L	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Missense_Mutation_p.R748L|AP2A1_uc002ppp.1_3'UTR|AP2A1_uc010enk.2_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	770					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		TCAGAGTTCCGACAGAACCTG	0.617													13	28					2.32078e-09	2.8446e-09	1	0	T	50306435	T	T	50306435	3	4	170	1	0	0	0	0	1	0	0	0	739	1058	37	3	2379	3	AP2A1	19	50306435	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1698568	50306435	8822548	275	32111											
ZNF528	84436	broad.mit.edu	37	chr19	52905281	52905281	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaggaatggcccttactcaGgtaaggtaatgttctcagtg	10	12	11	8	0	3	0	3	0	1	0	4	1	3	1	1	4	1	3	1	4	4	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:52905281G>A	uc002pzh.2	+	4	441	c.15G>A	c.(13-15)CAG>CAA	p.Q5Q	ZNF528_uc002pzi.2_5'UTR	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		CCCTTACTCAGGTAAGGTAAT	0.418													5	26					0	0	0	0	A	52905281	A	A	52905281	2	1	170	1	0	0	0	0	0	0	0	1	18036	1014	35	4		4	ZNF528	19	52905281	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	2598846	52905281	6223702	276	32112											
LILRA1	11024	broad.mit.edu	37	chr19	55107222	55107222	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatttgttctgtataaggaGggagaacgtgacttcctcca	11	12	11	7	1	1	3	0	1	1	2	3	5	3	4	2	2	1	2	2	2	3	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:55107222G>A	uc002qgh.1	+	6	962	c.780G>A	c.(778-780)GAG>GAA	p.E260E	LILRA2_uc010yfg.1_Silent_p.E258E|LILRA1_uc010yfh.1_Silent_p.E260E	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	260	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		TGTATAAGGAGGGAGAACGTG	0.617													25	66					0	0	0	0	A	55107222	A	A	55107222	2	1	170	1	0	0	0	0	0	0	0	1	8825	991	35	4		4	LILRA1	19	55107222	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	2201941	55107222	4021761	277	32113											
KIR2DL1	3802	broad.mit.edu	37	chr19	55285082	55285082	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccctctggacatcgtgatcaTaggtgagagtgtccagactt	9	11	11	10	1	2	3	1	2	1	2	4	5	3	4	2	2	0	0	2	2	1	2	rs80323556	byFrequency	TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:55285082T>A	uc002qhb.1	+	3	406	c.368T>A	c.(367-369)ATA>AAA	p.I123K	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.I123K	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	123	Extracellular (Potential).				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		ATCGTGATCATAGGTGAGAGT	0.512													48	119					0	0	0	0	A	55285082	A	A	55285082	3	1	170	1	0	0	0	0	1	0	0	0	8355	1406	49	5	378	5	KIR2DL1	19	55285082	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	177860	55285082	3843901	278	32114											
NLRP13	126204	broad.mit.edu	37	chr19	56423633	56423633	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgaagaatattgaactcgTagagagaatcaatgaaaggc	17	10	10	4	1	1	6	1	3	0	3	2	7	1	6	0	1	1	1	0	1	8	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:56423633T>C	uc010ygg.1	-	5	1575	c.1550A>G	c.(1549-1551)TAC>TGC	p.Y517C		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	517	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ATTGAACTCGTAGAGAGAATC	0.448													14	25					0	0	0	0	C	56423633	C	C	56423633	3	2	170	1	0	0	0	0	1	0	0	0	10529	1638	57	5	1607	5	NLRP13	19	56423633	Missense_Mutation	SNP	T	TCGA-CV-5432-01A-02D-1683-08	1138551	56423633	2705350	279	32115											
NLRP8	126205	broad.mit.edu	37	chr19	56485041	56485041	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaactgcaaccttacacAgcttacttgtgaaagccttg	13	10	8	10	0	0	2	0	1	0	1	0	3	0	2	2	0	7	2	2	0	5	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:56485041A>T	uc002qmh.2	+	7	2629	c.2558A>T	c.(2557-2559)CAG>CTG	p.Q853L	NLRP8_uc010etg.2_Intron	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	853	LRR 3.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AACCTTACACAGCTTACTTGT	0.498													45	112					0	0	0	0	T	56485041	T	T	56485041	3	4	170	1	0	0	0	0	1	0	0	0	10537	188	7	5	2584	5	NLRP8	19	56485041	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	61408	56485041	2643942	280	32116											
ZNF304	57343	broad.mit.edu	37	chr19	57868528	57868528	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtggaaaattctttagccatAactctagcctcattaaacat	14	13	5	9	0	3	0	1	0	2	0	3	1	3	1	2	1	4	0	2	1	7	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:57868528A>T	uc010ygw.1	+	3	1679	c.1291A>T	c.(1291-1293)AAC>TAC	p.N431Y	ZNF304_uc010etw.2_Missense_Mutation_p.N478Y|ZNF304_uc010etx.2_Missense_Mutation_p.N389Y	NM_020657	NP_065708	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	431	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CTTTAGCCATAACTCTAGCCT	0.453													11	26					0	0	0	0	T	57868528	T	T	57868528	3	4	170	1	0	0	0	0	1	0	0	0	17900	362	13	5	1301	5	ZNF304	19	57868528	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	1383487	57868528	1260455	281	32117											
ZNF419	79744	broad.mit.edu	37	chr19	58001541	58001541	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggctgcagacttgcttacAgaccatgaggaggtaagtgg	10	9	15	7	0	0	3	0	1	0	2	0	4	0	4	1	4	3	4	1	4	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:58001541A>C	uc002qov.2	+	2	300	c.60A>C	c.(58-60)ACA>ACC	p.T20T	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Silent_p.T20T|ZNF419_uc010etz.1_Intron|ZNF419_uc010eua.1_Intron|ZNF419_uc002qow.2_Silent_p.T20T|ZNF419_uc010eub.1_Intron|ZNF419_uc010euc.1_Intron	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		ACTTGCTTACAGACCATGAGG	0.498													10	21					0	0	0	0	C	58001541	C	C	58001541	2	2	170	1	0	0	0	0	0	0	0	1	17963	175	7	5		5	ZNF419	19	58001541	Silent	SNP	A	TCGA-CV-5432-01A-02D-1683-08	133013	58001541	1127442	282	32118											
ZNF132	7691	broad.mit.edu	37	chr19	58945609	58945609	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgactgcactcataaggtCttacctgtgtgtgaactttc	9	15	8	9	0	2	2	1	2	1	0	3	2	2	2	1	1	3	1	1	1	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:58945609C>G	uc002qst.3	-	3	1603	c.1202G>C	c.(1201-1203)AGA>ACA	p.R401T		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	401						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		CTCATAAGGTCTTACCTGTGT	0.473													17	55					0	0	0	0	G	58945609	G	G	58945609	3	3	170	1	0	0	0	0	1	0	0	0	17789	913	32	2	922	2	ZNF132	19	58945609	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	944068	58945609	183374	283	32119			1	47		5	5	420	C		1.268787e-11
ZNF132	7691	broad.mit.edu	37	chr19	58945629	58945629	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttacctgtgtgtgaactttCtgatgccgaaggaaattgga	10	13	11	7	1	1	2	0	2	1	0	1	5	1	4	2	2	3	0	2	2	4	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:58945629C>G	uc002qst.3	-	3	1583	c.1182G>C	c.(1180-1182)CAG>CAC	p.Q394H		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	394	C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		TGTGAACTTTCTGATGCCGAA	0.478													17	55					0	0	0	0	G	58945629	G	G	58945629	3	3	170	1	0	0	0	0	1	0	0	0	17789	912	32	2	942	2	ZNF132	19	58945629	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	20	58945629	183354	284	32120			1	47		5	5	420	C		1.268787e-11
ZNF132	7691	broad.mit.edu	37	chr19	58945685	58945685	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttccacatttcaggcactCaaaaggcctttctccagtgt	9	13	6	13	0	4	0	2	0	2	0	6	0	5	0	3	2	0	1	3	2	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:58945685C>G	uc002qst.3	-	3	1527	c.1126G>C	c.(1126-1128)GAG>CAG	p.E376Q		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	376	C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		TTCAGGCACTCAAAAGGCCTT	0.458													14	40					0	0	0	0	G	58945685	G	G	58945685	3	3	170	1	0	0	0	0	1	0	0	0	17789	835	29	2	998	2	ZNF132	19	58945685	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	56	58945685	183298	285	32121			1	47		5	5	420	C		1.268787e-11
ZNF132	7691	broad.mit.edu	37	chr19	58945763	58945763	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggctttcccacattcatCacactcataaggtctttctc	10	13	5	13	0	5	0	3	0	2	0	7	1	6	0	1	2	0	1	1	2	2	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:58945763C>A	uc002qst.3	-	3	1449	c.1048G>T	c.(1048-1050)GAT>TAT	p.D350Y		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	350	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		CCACATTCATCACACTCATAA	0.418													12	50					3.07112e-06	3.46054e-06	1	0	A	58945763	A	A	58945763	3	1	170	1	0	0	0	0	1	0	0	0	17789	826	29	2	1076	2	ZNF132	19	58945763	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	78	58945763	183220	286	32122			1	47		5	5	420	C		1.268787e-11
ZNF132	7691	broad.mit.edu	37	chr19	58946028	58946028	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgggcatgtaaatggtatCtcttcagagtgagttctcag	9	14	12	6	0	3	2	2	1	2	1	5	2	3	2	0	2	0	5	0	2	3	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr19:58946028C>G	uc002qst.3	-	3	1184	c.783G>C	c.(781-783)GAG>GAC	p.E261D		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	261						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		TAAATGGTATCTCTTCAGAGT	0.443													16	83					0	0	0	0	G	58946028	G	G	58946028	3	3	170	1	0	0	0	0	1	0	0	0	17789	912	32	2	1341	2	ZNF132	19	58946028	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	265	58946028	182955	287	32123			1	47		5	5	420	C		1.268787e-11
SNPH	9751	broad.mit.edu	37	chr20	1285749	1285749	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaacaagaagctggagaCgctgctgcacagcatggagg	13	4	14	10	1	0	3	0	0	0	3	0	5	0	4	1	3	5	5	1	3	3	0	rs144660706		TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr20:1285749C>T	uc002wes.2	+	6	772	c.536C>T	c.(535-537)ACG>ATG	p.T179M	SNPH_uc002wet.2_Missense_Mutation_p.T223M	NM_014723	NP_055538	O15079	SNPH_HUMAN	syntaphilin	179					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			ovary(2)	2						AAGCTGGAGACGCTGCTGCAC	0.587													11	30					0	0	0	0	T	1285749	T	T	1285749	3	4	170	1	0	0	0	0	1	0	0	0	14914	536	19	1	550	1	SNPH	20	1285749	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08		1285749	61739771	288	32124											
MACROD2	140733	broad.mit.edu	37	chr20	14066362	14066362	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattgctagaggtagatgctAtagtcaatgccggtgagtag	11	11	13	6	1	1	3	1	1	0	2	1	3	1	3	1	2	3	4	1	2	6	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr20:14066362A>G	uc002wou.2	+	3	523	c.259A>G	c.(259-261)ATA>GTA	p.I87V	MACROD2_uc002wot.2_Missense_Mutation_p.I87V	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1	87	Macro.										0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				GGTAGATGCTATAGTCAATGC	0.308													6	25					0	0	0	0	G	14066362	G	G	14066362	3	3	170	1	0	0	0	0	1	0	0	0	9197	449	16	5	269	5	MACROD2	20	14066362	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	12780613	14066362	48959158	289	32125											
RRBP1	6238	broad.mit.edu	37	chr20	17600950	17600950	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagagcacatacctggtcCgaactttcaagttctccttt	10	12	7	12	1	2	1	1	0	1	1	4	2	3	1	3	1	4	3	3	1	3	4	rs138279227		TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr20:17600950C>T	uc002wpv.1	-	19	2628	c.2274G>A	c.(2272-2274)TCG>TCA	p.S758S	RRBP1_uc010zrp.1_5'Flank|RRBP1_uc002wpt.1_Silent_p.S128S|RRBP1_uc002wpu.2_Silent_p.S532S|RRBP1_uc002wpw.1_Silent_p.S758S|RRBP1_uc010gcl.1_Silent_p.S532S|RRBP1_uc010gcm.1_3'UTR	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1191	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						ATACCTGGTCCGAACTTTCAA	0.488													27	85					0	0	0	0	T	17600950	T	T	17600950	2	4	170	1	0	0	0	0	0	0	0	1	13743	639	23	1		1	RRBP1	20	17600950	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	3534588	17600950	45424570	290	32126											
PAX1	5075	broad.mit.edu	37	chr20	21687085	21687085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgcatccgcagagcagacgtAtggcgaggtgaaccagctgg	10	5	15	11	4	0	3	0	1	0	2	1	4	1	3	2	3	3	5	2	3	2	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr20:21687085A>G	uc002wsj.2	+	2	350	c.296A>G	c.(295-297)TAT>TGT	p.Y99C	PAX1_uc010zsl.1_Missense_Mutation_p.Y99C|PAX1_uc010zsm.1_Missense_Mutation_p.Y75C	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	99	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						GAGCAGACGTATGGCGAGGTG	0.672													12	34					0	0	0	0	G	21687085	G	G	21687085	3	3	170	1	0	0	0	0	1	0	0	0	11532	449	16	5	302	5	PAX1	20	21687085	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	4086135	21687085	41338435	291	32127											
TRPC4AP	26133	broad.mit.edu	37	chr20	33609096	33609096	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgactggggcagctgggttCtggctgacgtgtgaggcagg	5	10	19	7	1	1	3	0	3	1	0	1	3	1	3	0	6	1	5	0	6	0	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr20:33609096C>T	uc002xbk.2	-	9	1149	c.1115G>A	c.(1114-1116)AGA>AAA	p.R372K	TRPC4AP_uc010zuq.1_Intron|TRPC4AP_uc002xbl.2_Missense_Mutation_p.R364K|TRPC4AP_uc010zur.1_Missense_Mutation_p.R333K|TRPC4AP_uc002xbm.1_Missense_Mutation_p.R372K	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	372	Interaction with TNFRSF1A (By similarity).				protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			CAGCTGGGTTCTGGCTGACGT	0.552													13	31					0	0	0	0	T	33609096	T	T	33609096	3	4	170	1	0	0	0	0	1	0	0	0	16648	913	32	2	1322	2	TRPC4AP	20	33609096	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	11922011	33609096	29416424	292	32128											
TGM2	7052	broad.mit.edu	37	chr20	36776383	36776383	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catgccactcaccacccggcCcacgtagacggggctgctgc	7	5	11	18	3	1	1	1	0	0	1	1	1	1	1	4	3	3	3	4	3	1	1			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr20:36776383C>A	uc002xhr.2	-	5	761	c.661G>T	c.(661-663)GGC>TGC	p.G221C	TGM2_uc010zvx.1_Missense_Mutation_p.G140C|TGM2_uc010zvy.1_Missense_Mutation_p.G161C|TGM2_uc002xhs.1_Missense_Mutation_p.G197C|TGM2_uc002xht.2_Missense_Mutation_p.G221C|TGM2_uc002xhu.3_Missense_Mutation_p.G221C	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	221					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	ACCACCCGGCCCACGTAGACG	0.652													7	10					0.000442599	0.000466459	1	0	A	36776383	A	A	36776383	3	1	170	1	0	0	0	0	1	0	0	0	15896	623	22	4	1470	4	TGM2	20	36776383	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	3167287	36776383	26249137	293	32129											
GDAP1L1	78997	broad.mit.edu	37	chr20	42885797	42885797	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accctggcgcctgcaggtgcGgctggtgatcgccgagaagg	6	6	17	12	4	0	2	0	1	0	1	1	3	0	2	3	5	2	2	3	5	1	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr20:42885797G>T	uc002xlq.2	+	2	252	c.185G>T	c.(184-186)CGG>CTG	p.R62L	GDAP1L1_uc002xlp.1_Missense_Mutation_p.R62L|GDAP1L1_uc010zwl.1_Missense_Mutation_p.R62L|GDAP1L1_uc010zwm.1_Missense_Mutation_p.R62L|GDAP1L1_uc010zwn.1_Intron	NM_024034	NP_076939	Q96MZ0	GD1L1_HUMAN	ganglioside-induced differentiation-associated	62	GST N-terminal.									large_intestine(1)	1		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CTGCAGGTGCGGCTGGTGATC	0.706													10	3					0.000442599	0.000466459	1	0	T	42885797	T	T	42885797	3	4	170	1	0	0	0	0	1	0	0	0	6344	1116	39	3	191	3	GDAP1L1	20	42885797	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	6109414	42885797	20139723	294	32130											
CBLN4	140689	broad.mit.edu	37	chr20	54575848	54575848	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaactgtaaattccttttCttggtgctacaaagacagac	13	13	7	8	0	1	3	0	1	1	2	2	3	2	3	1	1	3	2	1	1	5	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr20:54575848C>G	uc002xxa.2	-	2	1132	c.347G>C	c.(346-348)AGA>ACA	p.R116T		NM_080617	NP_542184	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	116	C1q.					cell junction|extracellular region|synapse				ovary(3)|pancreas(1)	4			Colorectal(105;0.202)			AATTCCTTTTCTTGGTGCTAC	0.323													22	63					0	0	0	0	G	54575848	G	G	54575848	3	3	170	1	0	0	0	0	1	0	0	0	2719	913	32	2	266	2	CBLN4	20	54575848	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	11690051	54575848	8449672	295	32131											
ZNF831	128611	broad.mit.edu	37	chr20	57781960	57781960	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catgcttctctcttctacagGtacaaagggaatttcttgca	10	14	7	10	0	4	0	0	0	4	0	5	1	4	1	0	2	4	3	0	2	4	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr20:57781960G>C	uc002yan.2	+	3	3876	c.3876G>C	c.(3874-3876)AGG>AGC	p.R1292S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1292						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCTTCTACAGGTACAAAGGGA	0.532													63	214					0	0	0	0	C	57781960	C	C	57781960	3	2	170	1	0	0	0	0	1	0	0	0	18252	1275	44	4	3886	4	ZNF831	20	57781960	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	3206112	57781960	5243560	296	32132											
C21orf45	54069	broad.mit.edu	37	chr21	33647184	33647184	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggatagcttctgttccttatCcacagaaacattacaggaaa	14	11	7	9	0	1	1	0	0	1	1	3	3	3	3	2	2	3	2	2	2	5	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr21:33647184C>G	uc002ypi.2	-	2	409	c.358G>C	c.(358-360)GAT>CAT	p.D120H	C21orf45_uc011adn.1_Missense_Mutation_p.D120H	NM_018944	NP_061817	Q9NYP9	MS18A_HUMAN	chromosome 21 open reading frame 45	120					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm					0						TGTTCCTTATCCACAGAAACA	0.303													17	4					0	0	0	0	G	33647184	G	G	33647184	3	3	170	1	0	0	0	0	1	0	0	0	2136	855	30	2	359	2	C21orf45	21	33647184	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08		33647184	14482711	297	32133											
PDE9A	5152	broad.mit.edu	37	chr21	44195393	44195393	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtttcccttcttccaggagActgtgcctgaggaaagcggg	7	10	13	11	2	1	2	0	1	1	1	3	4	3	3	3	3	2	1	3	3	1	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr21:44195393A>G	uc002zbm.2	+	20	1835	c.1772A>G	c.(1771-1773)GAC>GGC	p.D591G	PDE9A_uc002zbn.2_Missense_Mutation_p.D464G|PDE9A_uc002zbo.2_Missense_Mutation_p.D538G|PDE9A_uc002zbp.2_Missense_Mutation_p.D384G|PDE9A_uc002zbq.2_Missense_Mutation_p.D489G|PDE9A_uc002zbs.2_Missense_Mutation_p.D384G|PDE9A_uc002zbr.2_Missense_Mutation_p.D384G|PDE9A_uc002zbt.2_Missense_Mutation_p.D463G|PDE9A_uc002zbu.2_Missense_Mutation_p.D457G|PDE9A_uc002zbv.2_Missense_Mutation_p.D431G|PDE9A_uc002zbw.2_Missense_Mutation_p.D374G|PDE9A_uc002zbx.2_Missense_Mutation_p.D531G|PDE9A_uc002zby.2_Missense_Mutation_p.D374G|PDE9A_uc002zbz.2_Missense_Mutation_p.D483G|PDE9A_uc002zca.2_Missense_Mutation_p.D550G|PDE9A_uc002zcb.2_Missense_Mutation_p.D565G|PDE9A_uc002zcc.2_Missense_Mutation_p.D490G|PDE9A_uc002zcd.2_Missense_Mutation_p.D505G|PDE9A_uc002zce.2_Missense_Mutation_p.D524G|PDE9A_uc002zcf.2_Missense_Mutation_p.D384G|PDE9A_uc002zcg.2_Missense_Mutation_p.D384G|PDE9A_uc002zch.2_Missense_Mutation_p.D374G	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	591					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						CTTCCAGGAGACTGTGCCTGA	0.433													32	57					0	0	0	0	G	44195393	G	G	44195393	3	3	170	1	0	0	0	0	1	0	0	0	11709	275	10	5	1930	5	PDE9A	21	44195393	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08	10548209	44195393	3934502	298	32134											
GGTLC2	91227	broad.mit.edu	37	chr22	22989484	22989484	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctctcgtcaatgtgcccgacGatcatggtgggccaggacgg	7	8	14	12	4	3	0	2	0	1	0	4	3	3	1	2	4	1	0	2	4	1	0	rs139520107		TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr22:22989484G>C	uc010gtt.2	+	3	370	c.336G>C	c.(334-336)ACG>ACC	p.T112T	LOC96610_uc011aim.1_Intron|POM121L1P_uc011ait.1_5'Flank|GGTLC2_uc010gts.2_Silent_p.T112T	NM_199127	NP_954578	Q14390	GGTL2_HUMAN	gamma-glutamyltransferase-like 4 isoform 1	112					glutathione biosynthetic process		gamma-glutamyltransferase activity			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		TGTGCCCGACGATCATGGTGG	0.647													34	96					0	0	0	0	C	22989484	C	C	22989484	2	2	170	1	0	0	0	0	0	0	0	1	6403	1045	37	3		3	GGTLC2	22	22989484	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08		22989484	28315082	299	32135											
APOBEC3B	9582	broad.mit.edu	37	chr22	39387522	39387522	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcaggagaacacacacgtGagactgcgcatcttcgctgc	10	8	10	13	3	2	2	1	1	1	2	3	4	2	2	0	1	3	2	0	1	1	2			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr22:39387522G>C	uc003awo.1	+	6	963	c.909G>C	c.(907-909)GTG>GTC	p.V303V	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Silent_p.V278V|APOBEC3B_uc003awq.1_RNA|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	303					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					ACACACACGTGAGACTGCGCA	0.582													25	203					0	0	0	0	C	39387522	C	C	39387522	2	2	170	1	0	0	0	0	0	0	0	1	790	1277	45	2		2	APOBEC3B	22	39387522	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	16398038	39387522	11917044	300	32136											
ATXN10	25814	broad.mit.edu	37	chr22	46114314	46114314	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttgattattacagacctCtttctgaaaagcccggaatt	11	15	6	9	1	3	3	0	2	3	1	3	4	3	4	2	1	2	0	2	1	5	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chr22:46114314C>T	uc003bgm.1	+	6	926	c.669C>T	c.(667-669)CTC>CTT	p.L223L	ATXN10_uc011aqt.1_Silent_p.L159L|ATXN10_uc003bgn.1_Silent_p.L34L	NM_013236	NP_037368	Q9UBB4	ATX10_HUMAN	ataxin 10	223					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				ovary(1)|kidney(1)	2		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		TTACAGACCTCTTTCTGAAAA	0.418													26	115					0	0	0	0	T	46114314	T	T	46114314	2	4	170	1	0	0	0	0	0	0	0	1	1212	900	32	2		2	ATXN10	22	46114314	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	6726792	46114314	5190252	301	32137											
GPR64	10149	broad.mit.edu	37	chrX	19022897	19022897	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaaagctatgtaggttacaAgagtcactgacagaaaaatt	18	9	8	6	0	1	3	1	1	0	2	1	3	1	3	0	1	2	3	0	1	8	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:19022897A>G	uc004cyx.2	-	23	2104	c.1940T>C	c.(1939-1941)CTT>CCT	p.L647P	GPR64_uc004cyy.2_Missense_Mutation_p.L644P|GPR64_uc004cyz.2_Missense_Mutation_p.L633P|GPR64_uc004czb.2_Missense_Mutation_p.L647P|GPR64_uc004czc.2_Missense_Mutation_p.L631P|GPR64_uc004czd.2_Missense_Mutation_p.L623P|GPR64_uc004cze.2_Missense_Mutation_p.L617P|GPR64_uc004czf.2_Missense_Mutation_p.L609P|GPR64_uc004cza.2_Missense_Mutation_p.L625P|GPR64_uc004cyw.2_Missense_Mutation_p.L631P|GPR64_uc010nfj.2_Missense_Mutation_p.L528P	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	647	Helical; Name=1; (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					GTAGGTTACAAGAGTCACTGA	0.388													55	30					0	0	0	0	G	19022897	G	G	19022897	3	3	170	1	0	0	0	0	1	0	0	0	6743	72	3	5	1141	5	GPR64	23	19022897	Missense_Mutation	SNP	A	TCGA-CV-5432-01A-02D-1683-08		19022897	136247663	302	32138											
FAM47C	442444	broad.mit.edu	37	chrX	37028482	37028482	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agactcgggtgtccagtctcCccccggagccccccgagact	6	6	11	18	3	1	2	0	0	1	2	4	4	2	3	7	2	1	0	7	2	0	0			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:37028482C>T	uc004ddl.1	+	1	2013	c.1999C>T	c.(1999-2001)CCC>TCC	p.P667S		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	667										ovary(3)	3						GTCCAGTCTCCCCCCGGAGCC	0.642													14	9					0	0	0	0	T	37028482	T	T	37028482	3	4	170	1	0	0	0	0	1	0	0	0	5603	623	22	4	2001	4	FAM47C	23	37028482	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	18005585	37028482	118242078	303	32139											
FGD1	2245	broad.mit.edu	37	chrX	54492197	54492197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgttgaccagctccacggCccggtcaaagttcttcacat	8	10	10	13	2	3	1	2	1	1	0	4	1	4	1	3	3	1	3	3	3	1	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:54492197C>T	uc004dtg.2	-	7	2163	c.1429G>A	c.(1429-1431)GCC>ACC	p.A477T	FGD1_uc011moi.1_Missense_Mutation_p.A235T	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	477	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						AGCTCCACGGCCCGGTCAAAG	0.542													17	4					0	0	0	0	T	54492197	T	T	54492197	3	4	170	1	0	0	0	0	1	0	0	0	5864	739	26	4	1504	4	FGD1	23	54492197	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	17463715	54492197	100778363	304	32140											
STARD8	9754	broad.mit.edu	37	chrX	67938280	67938280	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cattcaggcggggaacccacCtttgcctctagcctgtctgt	6	11	10	14	1	3	0	1	0	2	0	3	1	3	1	4	3	3	0	4	3	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:67938280C>A	uc004dxa.2	+	5	1656	c.1284C>A	c.(1282-1284)ACC>ACA	p.T428T	STARD8_uc004dxb.2_Silent_p.T508T|STARD8_uc004dxc.3_Silent_p.T428T	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	428					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						GGGAACCCACCTTTGCCTCTA	0.458													6	6					5.18039e-06	5.77075e-06	1	0	A	67938280	A	A	67938280	2	1	170	1	0	0	0	0	0	0	0	1	15329	668	24	4		4	STARD8	23	67938280	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	13446083	67938280	87332280	305	32141											
KIAA2022	340533	broad.mit.edu	37	chrX	73962130	73962130	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctttaaattagcctttgaGgattggttttccaagagagg	10	16	10	5	0	1	2	0	1	1	1	2	4	2	3	2	3	1	1	2	3	4	8			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:73962130G>T	uc004eby.2	-	3	2879	c.2262C>A	c.(2260-2262)TCC>TCA	p.S754S		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	754					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TAGCCTTTGAGGATTGGTTTT	0.388													21	12					5.26018e-13	6.78789e-13	1	0	T	73962130	T	T	73962130	2	4	170	1	0	0	0	0	0	0	0	1	8308	987	35	4		4	KIAA2022	23	73962130	Silent	SNP	G	TCGA-CV-5432-01A-02D-1683-08	6023850	73962130	81308430	306	32142											
MAGEE2	139599	broad.mit.edu	37	chrX	75004022	75004022	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttggttttgtcaccttccaGggccttattatattcttctg	5	20	7	9	0	3	0	1	0	2	0	4	0	4	0	3	2	0	1	3	2	3	9			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:75004022G>T	uc004ecj.1	-	1	1050	c.865C>A	c.(865-867)CTG>ATG	p.L289M		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	289										ovary(1)|skin(1)	2						TCACCTTCCAGGGCCTTATTA	0.473													10	17					4.68919e-08	5.55598e-08	1	0	T	75004022	T	T	75004022	3	4	170	1	0	0	0	0	1	0	0	0	9239	991	35	4	710	4	MAGEE2	23	75004022	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	1041892	75004022	80266538	307	32143											
CXorf57	55086	broad.mit.edu	37	chrX	105882844	105882844	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaagcgcattgcaattcaggGgataattactgctataaagt	15	11	9	6	1	1	0	1	0	0	0	1	1	1	1	0	2	4	3	0	2	7	6			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:105882844G>T	uc004emi.3	+	9	1812	c.1661G>T	c.(1660-1662)GGG>GTG	p.G554V	CXorf57_uc004emj.3_Intron	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	554										ovary(1)|lung(1)|breast(1)	3						GCAATTCAGGGGATAATTACT	0.423													41	22					1.07121e-22	1.49587e-22	1	0	T	105882844	T	T	105882844	3	4	170	1	0	0	0	0	1	0	0	0	4130	1232	43	4	1695	4	CXorf57	23	105882844	Missense_Mutation	SNP	G	TCGA-CV-5432-01A-02D-1683-08	30878822	105882844	49387716	308	32144											
AMOT	154796	broad.mit.edu	37	chrX	112033827	112033827	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctacctacttacctctgagCagccacagttgcagcagcat	10	9	8	14	0	1	1	0	1	1	0	1	1	1	1	3	0	8	6	3	0	3	4			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:112033827C>A	uc004epr.2	-	7	2110	c.2110G>T	c.(2110-2112)GCT>TCT	p.A704S	AMOT_uc004eps.2_Missense_Mutation_p.A295S	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	704					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						TACCTCTGAGCAGCCACAGTT	0.428													77	48					9.61239e-26	1.36671e-25	1	0	A	112033827	A	A	112033827	3	1	170	1	0	0	0	0	1	0	0	0	582	710	25	4	1164	4	AMOT	23	112033827	Missense_Mutation	SNP	C	TCGA-CV-5432-01A-02D-1683-08	6150983	112033827	43236733	309	32145											
DOCK11	139818	broad.mit.edu	37	chrX	117783069	117783069	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtataccaaaaggaaaacCtttttgaggacacatctaca	17	9	7	8	0	1	1	0	1	1	0	1	4	1	3	2	2	3	1	2	2	7	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:117783069C>G	uc004eqp.2	+	41	4623	c.4560C>G	c.(4558-4560)ACC>ACG	p.T1520T	DOCK11_uc004eqq.2_Silent_p.T1299T	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1520	DHR-2.				blood coagulation	cytosol	GTP binding			ovary(3)	3						AAAGGAAAACCTTTTTGAGGA	0.358													34	18					0	0	0	0	G	117783069	G	G	117783069	2	3	170	1	0	0	0	0	0	0	0	1	4708	668	24	4		4	DOCK11	23	117783069	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	5749242	117783069	37487491	310	32146											
MAGEC1	9947	broad.mit.edu	37	chrX	140995560	140995560	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctacactttagcgagtctTctccaaagttcccatgagag	10	12	7	12	1	2	1	0	1	2	1	5	3	4	1	3	0	2	1	3	0	3	5			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:140995560T>C	uc004fbt.2	+	4	2656	c.2370T>C	c.(2368-2370)CTT>CTC	p.L790L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	790							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TAGCGAGTCTTCTCCAAAGTT	0.567										HNSCC(15;0.026)			69	37					0	0	0	0	C	140995560	C	C	140995560	2	2	170	1	0	0	0	0	0	0	0	1	9233	1770	62	5		5	MAGEC1	23	140995560	Silent	SNP	T	TCGA-CV-5432-01A-02D-1683-08	23212491	140995560	14275000	311	32147											
MAGEC1	9947	broad.mit.edu	37	chrX	140995929	140995929	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactggatgaaaaggtggaCgagttggcgcggtttcttct	9	11	14	7	3	2	1	0	1	2	0	2	4	2	3	0	5	0	2	0	5	2	3			TCGA-CV-5432-01A-02D-1683-08	TCGA-CV-5432-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	91e9ac70-5524-4b13-9d53-7cec52b38ea5	56233478-0d9d-4a64-acfc-feee0c55ab94	g.chrX:140995929C>T	uc004fbt.2	+	4	3025	c.2739C>T	c.(2737-2739)GAC>GAT	p.D913D	MAGEC1_uc010nsl.1_Translation_Start_Site	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	913	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AAAAGGTGGACGAGTTGGCGC	0.488										HNSCC(15;0.026)			58	37					0	0	0	0	T	140995929	T	T	140995929	2	4	170	1	0	0	0	0	0	0	0	1	9233	535	19	1		1	MAGEC1	23	140995929	Silent	SNP	C	TCGA-CV-5432-01A-02D-1683-08	369	140995929	14274631	312	32148											
PLEKHG5	57449	broad.mit.edu	37	chr1	6531696	6531696	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacaggcgctccgcctccAcctgggcgcggcgggaggtg	5	5	17	14	5	0	1	0	1	0	0	2	2	2	2	4	5	1	1	4	5	1	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:6531696A>T	uc001ano.1	-	13	1402	c.1301T>A	c.(1300-1302)GTG>GAG	p.V434E	PLEKHG5_uc001ann.1_Missense_Mutation_p.V415E|PLEKHG5_uc001anq.1_Missense_Mutation_p.V455E|PLEKHG5_uc001anp.1_Missense_Mutation_p.V455E|PLEKHG5_uc001anj.1_5'Flank|PLEKHG5_uc009vma.1_Missense_Mutation_p.V218E|PLEKHG5_uc010nzr.1_Missense_Mutation_p.V447E|PLEKHG5_uc001ank.1_Missense_Mutation_p.V378E|PLEKHG5_uc009vmb.1_Missense_Mutation_p.V378E|PLEKHG5_uc001anl.1_Missense_Mutation_p.V378E|PLEKHG5_uc001anm.1_Missense_Mutation_p.V378E|PLEKHG5_uc001anr.1_5'Flank	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	434	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CTCCGCCTCCACCTGGGCGCG	0.736													5	0					0	0	0	0	T	6531696	T	T	6531696	3	4	171	1	0	0	0	0	1	0	0	0	12128	173	6	5	1927	5	PLEKHG5	1	6531696	Missense_Mutation	SNP	A	TCGA-CV-5434-01A-01D-1683-08		6531696	242718925	1	32149											
FBXO44	93611	broad.mit.edu	37	chr1	11718615	11718615	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcctcaagtcccaggtggtgGacctcaaggccgaagggtat	9	7	14	11	1	2	0	2	0	0	0	3	2	3	1	4	5	0	1	4	5	4	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:11718615G>A	uc001asm.2	+	4	544	c.418G>A	c.(418-420)GAC>AAC	p.D140N	FBXO44_uc001ask.2_Intron|FBXO44_uc010oaq.1_3'UTR|FBXO44_uc001asl.2_Missense_Mutation_p.D140N|FBXO44_uc001asn.2_Intron|FBXO44_uc010oar.1_Missense_Mutation_p.G130E|FBXO44_uc010oas.1_Intron	NM_033182	NP_149438	Q9H4M3	FBX44_HUMAN	F-box protein 44 isoform 1	140	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGTGGTGGACCTCAAGGC	0.662													24	5					0	0	0	0	A	11718615	A	A	11718615	3	1	171	1	0	0	0	0	1	0	0	0	5785	1174	41	2	428	2	FBXO44	1	11718615	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	5186919	11718615	237532006	2	32150											
PRAMEF11	440560	broad.mit.edu	37	chr1	12887253	12887253	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgtagcgagagacatccaTgtgggagagaacgagcttct	13	7	13	8	3	1	2	0	0	1	2	2	7	2	3	1	1	4	2	1	1	3	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	2db53391-19dc-48e2-9636-d744b534591e	g.chr1:12887253T>C	uc001auk.2	-	3	800	c.604A>G	c.(604-606)ATG>GTG	p.M202V		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	202	LRR 1.										0						GAGACATCCATGTGGGAGAGA	0.502													6	24					0	0	0	0	C	12887253	C	C	12887253	3	2	171	1	0	0	0	0	1	0	0	0	12487	1464	51	5	714	5	PRAMEF11	1	12887253	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	1168638	12887253	236363368	3	32151											
ECE1	1889	broad.mit.edu	37	chr1	21585219	21585219	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgttggagttcttggaatcGgcactgacatagacagagaa	12	10	12	7	1	1	3	0	1	1	2	2	6	1	5	0	3	0	3	0	3	3	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:21585219G>C	uc001bek.2	-	6	804	c.729C>G	c.(727-729)GCC>GCG	p.A243A	ECE1_uc001bem.2_Silent_p.A227A|ECE1_uc001bej.2_Silent_p.A231A|ECE1_uc001bei.2_Silent_p.A240A|ECE1_uc010odl.1_Silent_p.A243A|ECE1_uc009vqa.1_Silent_p.A243A	NM_001397	NP_001388	P42892	ECE1_HUMAN	endothelin converting enzyme 1 isoform 1	243	Extracellular (Potential).				bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			ovary(2)|skin(1)	3		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		TCTTGGAATCGGCACTGACAT	0.572													7	31					0	0	0	0	C	21585219	C	C	21585219	2	2	171	1	0	0	0	0	0	0	0	1	4911	1103	39	3		3	ECE1	1	21585219	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	8697966	21585219	227665402	4	32152											
OPRD1	4985	broad.mit.edu	37	chr1	29185555	29185555	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcacgctgcctttccagaGtgccaagtacctgatggaga	10	8	11	12	1	0	3	0	1	0	2	1	4	1	3	4	1	4	3	4	1	2	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:29185555G>A	uc001brf.1	+	2	559	c.317G>A	c.(316-318)AGT>AAT	p.S106N		NM_000911	NP_000902	P41143	OPRD_HUMAN	opioid receptor, delta 1	106	Extracellular (Potential).				immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	CCTTTCCAGAGTGCCAAGTAC	0.537													52	20					0	0	0	0	A	29185555	A	A	29185555	3	1	171	1	0	0	0	0	1	0	0	0	10938	1029	36	4	323	4	OPRD1	1	29185555	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	7600336	29185555	220065066	5	32153											
COL24A1	255631	broad.mit.edu	37	chr1	86590952	86590952	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattcatttttgcctcactgAtgcgatgagtggtcactgac	8	15	9	9	1	3	3	3	3	0	0	3	4	3	3	1	1	2	0	1	1	1	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:86590952A>C	uc001dlj.2	-	3	1109	c.1067T>G	c.(1066-1068)ATC>AGC	p.I356S	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.I356S	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	356					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TGCCTCACTGATGCGATGAGT	0.418													25	19					0	0	0	0	C	86590952	C	C	86590952	3	2	171	1	0	0	0	0	1	0	0	0	3698	333	12	5	4309	5	COL24A1	1	86590952	Missense_Mutation	SNP	A	TCGA-CV-5434-01A-01D-1683-08	57405397	86590952	162659669	6	32154											
CELSR2	1952	broad.mit.edu	37	chr1	109794098	109794098	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccctcttgactatgagaCgaccaaggagtacaccctac	12	7	9	13	1	1	2	0	2	1	1	1	6	1	3	3	1	3	1	3	1	4	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:109794098C>T	uc001dxa.3	+	1	1458	c.1397C>T	c.(1396-1398)ACG>ATG	p.T466M		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	466	Cadherin 3.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GACTATGAGACGACCAAGGAG	0.547													38	113					0	0	0	0	T	109794098	T	T	109794098	3	4	171	1	0	0	0	0	1	0	0	0	3237	536	19	1	1399	1	CELSR2	1	109794098	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	23203146	109794098	139456523	7	32155											
ZNF697	90874	broad.mit.edu	37	chr1	120165879	120165879	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccaggtgcgaacggcgcaCgaagcccttgccgcactccc	7	4	13	17	5	0	0	0	0	0	0	1	2	1	0	4	3	4	2	4	3	2	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:120165879C>T	uc001ehy.1	-	3	1201	c.1087G>A	c.(1087-1089)GTG>ATG	p.V363M		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	363	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		GAACGGCGCACGAAGCCCTTG	0.502													2	1					0	0	0	0	T	120165879	T	T	120165879	3	4	171	1	0	0	0	0	1	0	0	0	18167	536	19	1	554	1	ZNF697	1	120165879	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	10371781	120165879	129084742	8	32156											
OR10R2	343406	broad.mit.edu	37	chr1	158450008	158450008	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggccaggacaatctcctTcaactgttgtgctcttcaaa	9	13	8	11	0	4	0	2	0	2	0	5	1	4	1	2	2	2	2	2	2	3	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:158450008T>C	uc010pik.1	+	1	341	c.341T>C	c.(340-342)TTC>TCC	p.F114S	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	114	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					ACAATCTCCTTCAACTGTTGT	0.438													140	117					0	0	0	0	C	158450008	C	C	158450008	3	2	171	1	0	0	0	0	1	0	0	0	10971	1783	62	5	343	5	OR10R2	1	158450008	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	38284129	158450008	90800613	9	32157											
OR6K2	81448	broad.mit.edu	37	chr1	158669969	158669969	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgtagagatccaggcaatCtcaggaaggggtgtgataaa	14	8	14	5	0	1	2	1	1	1	1	3	4	2	3	1	4	0	2	1	4	5	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:158669969C>G	uc001fsu.1	-	1	474	c.474G>C	c.(472-474)GAG>GAC	p.E158D		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TCCAGGCAATCTCAGGAAGGG	0.483													11	45					0	0	0	0	G	158669969	G	G	158669969	3	3	171	1	0	0	0	0	1	0	0	0	11256	912	32	2	504	2	OR6K2	1	158669969	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	219961	158669969	90580652	10	32158											
KCNJ10	3766	broad.mit.edu	37	chr1	160011784	160011784	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caactgcatgctggctgaaaCgaatggtctcagcccgcttc	9	9	10	13	2	1	1	1	1	1	0	3	2	1	1	1	2	5	4	1	2	3	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:160011784C>T	uc001fuw.1	-	2	689	c.539G>A	c.(538-540)CGT>CAT	p.R180H		NM_002241	NP_002232	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily	180	Cytoplasmic (By similarity).					integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTGGCTGAAACGAATGGTCTC	0.562													67	84					0	0	0	0	T	160011784	T	T	160011784	3	4	171	1	0	0	0	0	1	0	0	0	8083	536	19	1	604	1	KCNJ10	1	160011784	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	1341815	160011784	89238837	11	32159											
FCGR3A	2214	broad.mit.edu	37	chr1	161518384	161518384	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtcctcaggggagtaggctCcctggcacttcagagtcaca	8	9	12	12	0	3	1	3	0	0	1	5	2	5	2	2	4	0	3	2	4	1	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:161518384C>T	uc001gat.3	-	4	283	c.146G>A	c.(145-147)GGA>GAA	p.G49E	FCGR3A_uc001gar.2_Missense_Mutation_p.G85E|FCGR3A_uc001gas.2_Missense_Mutation_p.G84E|FCGR3A_uc009wuh.2_Missense_Mutation_p.G48E|FCGR3A_uc009wui.2_Missense_Mutation_p.G49E	NM_001127595	NP_001121067	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor	49	Ig-like C2-type 1.|Extracellular (Potential).				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGAGTAGGCTCCCTGGCACTT	0.542													33	247					0	0	0	0	T	161518384	T	T	161518384	3	4	171	1	0	0	0	0	1	0	0	0	5816	855	30	2	630	2	FCGR3A	1	161518384	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	1506600	161518384	87732237	12	32160											
ACBD6	84320	broad.mit.edu	37	chr1	180399399	180399399	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctttcttctctggtatcTgtgggaaggagaaaaaaaag	12	13	10	6	0	3	1	0	0	3	1	5	3	4	2	1	3	0	1	1	3	6	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:180399399T>A	uc001gog.2	-	4	1006	c.385_splice	c.e4-1	p.I129_splice		NM_032360	NP_115736	Q9BR61	ACBD6_HUMAN	acyl-coenzyme A binding domain containing 6							cytoplasm|nucleus	fatty-acyl-CoA binding			ovary(1)	1						CTCTGGTATCTGTGGGAAGGA	0.323													13	88					0	0	0	0	A	180399399	A	A	180399399	5	1	171	1	0	0	0	0	0	0	1	0	126	1594	55	5	485	5	ACBD6	1	180399399	Splice_Site	SNP	T	TCGA-CV-5434-01A-01D-1683-08	18881015	180399399	68851222	13	32161											
F13B	2165	broad.mit.edu	37	chr1	197032145	197032145	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	taaaagtatagtaatattggGcaattcttccattttccaca	14	15	5	7	0	1	0	0	0	1	0	3	0	3	0	2	1	0	3	2	1	7	10			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:197032145G>A	uc001gtt.1	-	2	151	c.107C>T	c.(106-108)GCC>GTC	p.A36V		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	36	Sushi 1.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GTAATATTGGGCAATTCTTCC	0.323													39	250					0	0	0	0	A	197032145	A	A	197032145	3	1	171	1	0	0	0	0	1	0	0	0	5366	1203	42	4	1922	4	F13B	1	197032145	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	16632746	197032145	52218476	14	32162											
ADIPOR1	51094	broad.mit.edu	37	chr1	202920154	202920155	+	Frame_Shift_Ins	INS	-	G	G																															cttccctgttactggcaggaINSgccccattcccctgtgccac																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:202920154_202920155insG	uc001gyq.3	-	2	311_312	c.44_45insC	c.(43-45)GCTfs	p.A15fs	ADIPOR1_uc010pqd.1_5'Flank|ADIPOR1_uc001gyr.3_5'UTR|ADIPOR1_uc001gys.3_Frame_Shift_Ins_p.A15fs	NM_015999	NP_057083	Q96A54	ADR1_HUMAN	adiponectin receptor 1	15	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity				0			BRCA - Breast invasive adenocarcinoma(75;0.141)			TACTGGCAGGAGCCCCATTCCC	0.559													---	---	---								G	202920155	G	G	202920154	7	5	171	1	0	1	1	0	0	0	0	0	318	291	11	0	1110	0	ADIPOR1	1	202920154	Frame_Shift_Ins	INS	-	TCGA-CV-5434-01A-01D-1683-08	5888009	202920154	46330467	15	32163											
PIGR	5284	broad.mit.edu	37	chr1	207105858	207105858	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccacggctcccactgccaGcaccaggcccaggggcacca	9	2	11	19	1	0	0	0	0	0	0	1	0	1	0	6	4	3	3	6	4	0	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:207105858G>A	uc001hez.2	-	8	2135	c.1951C>T	c.(1951-1953)CTG>TTG	p.L651L	PIGR_uc009xbz.2_Silent_p.L651L	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	651	Helical; (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCCACTGCCAGCACCAGGCCC	0.637													47	65					0	0	0	0	A	207105858	A	A	207105858	2	1	171	1	0	0	0	0	0	0	0	1	11952	962	34	4		4	PIGR	1	207105858	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	4185704	207105858	42144763	16	32164											
USH2A	7399	broad.mit.edu	37	chr1	216348641	216348641	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggagctgggaaatttacaaTacccatttcctatgaaacgg	13	11	9	8	1	0	1	0	1	0	0	1	3	1	3	2	3	4	1	2	3	6	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr1:216348641T>C	uc001hku.1	-	21	4967	c.4580A>G	c.(4579-4581)TAT>TGT	p.Y1527C	USH2A_uc001hkv.2_Missense_Mutation_p.Y1527C	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1527	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAATTTACAATACCCATTTCC	0.423										HNSCC(13;0.011)			10	55					0	0	0	0	C	216348641	C	C	216348641	3	2	171	1	0	0	0	0	1	0	0	0	17104	1406	49	5	11250	5	USH2A	1	216348641	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	9242783	216348641	32901980	17	32165											
ASAP2	8853	broad.mit.edu	37	chr2	9528612	9528612	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagtggcagcccacctcccGcccagcctgcagcccccagc	6	4	10	21	1	0	1	0	1	0	0	1	1	1	1	7	1	5	2	7	1	0	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr2:9528612G>C	uc002qzh.2	+	22	2660	c.2320G>C	c.(2320-2322)GCC>CCC	p.A774P	ASAP2_uc002qzi.2_Missense_Mutation_p.A774P	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	774	Pro-rich.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						CCCACCTCCCGCCCAGCCTGC	0.587													4	23					0	0	0	0	C	9528612	C	C	9528612	3	2	171	1	0	0	0	0	1	0	0	0	1013	1087	38	3	2406	3	ASAP2	2	9528612	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08		9528612	233670761	18	32166											
LRRTM1	347730	broad.mit.edu	37	chr2	80530203	80530203	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtccagcgagctgaccaCaatggccaccttgttcctcc	8	8	8	17	1	0	1	0	1	0	0	3	2	3	1	7	1	2	2	7	1	1	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr2:80530203C>T	uc002sok.1	-	2	1012	c.742G>A	c.(742-744)GTG>ATG	p.V248M	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	248	LRR 7.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GAGCTGACCACAATGGCCACC	0.592										HNSCC(69;0.2)			18	55					0	0	0	0	T	80530203	T	T	80530203	3	4	171	1	0	0	0	0	1	0	0	0	9089	478	17	4	830	4	LRRTM1	2	80530203	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	71001591	80530203	162669170	19	32167											
RETSAT	54884	broad.mit.edu	37	chr2	85570875	85570878	+	Frame_Shift_Del	DEL	AGAT	-	-																															aggcacctcggggagcagccAgatagaactggttggtgagt																								rs70953934		TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	2db53391-19dc-48e2-9636-d744b534591e	g.chr2:85570875_85570878delAGAT	uc002spd.2	-	10	1768_1771	c.1577_1580delATCT	c.(1576-1581)TATCTGfs	p.Y526fs	RETSAT_uc010fge.2_RNA|RETSAT_uc010ysm.1_Frame_Shift_Del_p.Y465fs|RETSAT_uc010fgf.2_Frame_Shift_Del_p.Y317fs	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	526_527					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	GGGAGCAGCCAGATAGAACTGGTT	0.637													---	---	---								-	85570878	-	-	85570875	7	5	171	1	0	1	0	1	0	0	0	0	13303	188	7	0	260	0	RETSAT	2	85570875	Frame_Shift_Del	DEL	AGAT	TCGA-CV-5434-01A-01D-1683-08	5040672	85570875	157628498	20	32168											
PROM2	150696	broad.mit.edu	37	chr2	95947688	95947688	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccagtttgcagacaccccaGggaacctgcccccgtccatg	8	6	9	18	1	0	1	0	0	0	1	1	2	1	2	7	1	3	2	7	1	1	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr2:95947688G>A	uc002suh.1	+	13	1700	c.1567G>A	c.(1567-1569)GGG>AGG	p.G523R	PROM2_uc002sui.2_Missense_Mutation_p.G523R|PROM2_uc002suj.2_Missense_Mutation_p.G177R|PROM2_uc002suk.2_Missense_Mutation_p.G523R|PROM2_uc002sul.2_Missense_Mutation_p.G49R|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	523	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						AGACACCCCAGGGAACCTGCC	0.627													19	39					0	0	0	0	A	95947688	A	A	95947688	3	1	171	1	0	0	0	0	1	0	0	0	12618	1000	35	4	1617	4	PROM2	2	95947688	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	10376813	95947688	147251685	21	32169											
ITPRIPL1	150771	broad.mit.edu	37	chr2	96993685	96993685	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagagcttaccccatggagCatcccgccccatcctcactt	8	9	6	18	1	2	1	2	0	0	1	4	2	4	2	6	1	3	2	6	1	1	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr2:96993685C>T	uc002svx.2	+	3	1651	c.1316C>T	c.(1315-1317)GCA>GTA	p.A439V	ITPRIPL1_uc010yuk.1_Missense_Mutation_p.A431V|ITPRIPL1_uc002svy.2_Missense_Mutation_p.A447V|ITPRIPL1_uc010yul.1_Missense_Mutation_p.A431V	NM_001008949	NP_001008949	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-triphosphate receptor interacting	439	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(2)|ovary(1)	3						CCCCATGGAGCATCCCGCCCC	0.562													42	67					0	0	0	0	T	96993685	T	T	96993685	3	4	171	1	0	0	0	0	1	0	0	0	7963	710	25	4	1356	4	ITPRIPL1	2	96993685	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	1045997	96993685	146205688	22	32170											
RAB3GAP1	22930	broad.mit.edu	37	chr2	135911438	135911438	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctttgatgatacacgggaaGcagaaaaggtaattgaggtt	14	11	12	4	1	1	4	0	3	1	1	1	5	1	5	0	3	2	3	0	3	5	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr2:135911438G>A	uc002tuj.2	+	19	2306	c.2281G>A	c.(2281-2283)GCA>ACA	p.A761T	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.A761T|RAB3GAP1_uc010fng.2_Missense_Mutation_p.A586T|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	761						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		TACACGGGAAGCAGAAAAGGT	0.418													5	36					0	0	0	0	A	135911438	A	A	135911438	3	1	171	1	0	0	0	0	1	0	0	0	13000	971	34	4	2355	4	RAB3GAP1	2	135911438	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	38917753	135911438	107287935	23	32171											
ZEB2	9839	broad.mit.edu	37	chr2	145187516	145187516	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccagagggttggcaatacCgtcatcctcagcaatatgaa	12	9	10	10	1	2	2	2	1	0	1	4	2	4	2	3	2	2	3	3	2	5	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr2:145187516C>T	uc002tvu.2	-	3	631	c.151G>A	c.(151-153)GGT>AGT	p.G51S	ZEB2_uc002tvv.2_Missense_Mutation_p.G46S|ZEB2_uc010zbm.1_Missense_Mutation_p.G46S|ZEB2_uc010fnp.2_Missense_Mutation_p.G46S|ZEB2_uc010fnq.1_Missense_Mutation_p.G80S|ZEB2_uc002tvw.2_Missense_Mutation_p.G46S	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	51						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TTGGCAATACCGTCATCCTCA	0.502													12	79					0	0	0	0	T	145187516	T	T	145187516	3	4	171	1	0	0	0	0	1	0	0	0	17691	652	23	1	3525	1	ZEB2	2	145187516	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	9276078	145187516	98011857	24	32172											
SSFA2	6744	broad.mit.edu	37	chr2	182783567	182783567	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagaattggcaatgctgcGtcagcaaaccatggtttatc	11	13	9	8	1	1	1	1	0	0	1	2	1	1	1	1	2	4	4	1	2	5	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr2:182783567G>A	uc002uoi.2	+	13	3273	c.2951G>A	c.(2950-2952)CGT>CAT	p.R984H	SSFA2_uc002uoh.2_Missense_Mutation_p.R984H|SSFA2_uc002uoj.2_Missense_Mutation_p.R984H|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.R831H|SSFA2_uc002uol.2_Missense_Mutation_p.R831H|SSFA2_uc002uom.2_Missense_Mutation_p.R452H	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	984	Potential.					cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			GCAATGCTGCGTCAGCAAACC	0.383													19	64					0	0	0	0	A	182783567	A	A	182783567	3	1	171	1	0	0	0	0	1	0	0	0	15249	1145	40	1	3001	1	SSFA2	2	182783567	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	37596051	182783567	60415806	25	32173											
KIF1A	547	broad.mit.edu	37	chr2	241706365	241706365	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggagtcgctccggaagaCgcagtgctcctccttgatga	7	9	12	13	3	0	3	0	2	0	1	4	5	3	5	4	2	1	3	4	2	1	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr2:241706365C>T	uc002vzy.2	-	18	1770	c.1624G>A	c.(1624-1626)GTC>ATC	p.V542I	KIF1A_uc010fzk.2_Missense_Mutation_p.V551I|KIF1A_uc002vzz.1_Missense_Mutation_p.V551I	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	542	FHA.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CTCCGGAAGACGCAGTGCTCC	0.637													4	8					0	0	0	0	T	241706365	T	T	241706365	3	4	171	1	0	0	0	0	1	0	0	0	8322	536	19	1	3568	1	KIF1A	2	241706365	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	58922798	241706365	1493008	26	32174											
SUMF1	285362	broad.mit.edu	37	chr3	4494724	4494724	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaaatactccagcagggaTggggaccatctacaatgaaa	15	8	10	8	0	1	1	0	1	1	0	2	3	2	3	2	3	3	2	2	3	6	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:4494724T>C	uc003bpz.1	-	2	305	c.280A>G	c.(280-282)ATC>GTC	p.I94V	SUMF1_uc003bps.1_RNA|SUMF1_uc011ass.1_Missense_Mutation_p.I94V|SUMF1_uc010hby.1_Missense_Mutation_p.I94V|SUMF1_uc011ast.1_Missense_Mutation_p.I94V	NM_182760	NP_877437	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1 isoform 1	94						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			upper_aerodigestive_tract(1)	1		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		CCAGCAGGGATGGGGACCATC	0.488													5	11					0	0	0	0	C	4494724	C	C	4494724	3	2	171	1	0	0	0	0	1	0	0	0	15451	1464	51	5	876	5	SUMF1	3	4494724	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08		4494724	193527706	27	32175											
CX3CR1	1524	broad.mit.edu	37	chr3	39307562	39307562	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgcctaggctgatggtgaCgccatgctgcacggtccggt	6	8	15	12	4	0	2	0	2	0	0	1	3	1	2	3	4	2	3	3	4	1	1	rs3732380	by1000genomes	TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:39307562C>T	uc003cjl.2	-	2	531	c.439G>A	c.(439-441)GTC>ATC	p.V147I		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	147	Helical; Name=4; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CTGATGGTGACGCCATGCTGC	0.527													4	48					0	0	0	0	T	39307562	T	T	39307562	3	4	171	1	0	0	0	0	1	0	0	0	4092	536	19	1	632	1	CX3CR1	3	39307562	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	34812838	39307562	158714868	28	32176											
BSN	8927	broad.mit.edu	37	chr3	49689861	49689861	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccagaccccagtctggacCgggagcctgagctggagatg	8	5	15	13	1	1	3	0	1	1	2	1	6	1	5	5	3	2	1	5	3	0	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:49689861C>T	uc003cxe.3	+	5	2986	c.2872C>T	c.(2872-2874)CGG>TGG	p.R958W		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	958					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CAGTCTGGACCGGGAGCCTGA	0.622													43	14					0	0	0	0	T	49689861	T	T	49689861	3	4	171	1	0	0	0	0	1	0	0	0	1535	643	23	1	2890	1	BSN	3	49689861	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	10382299	49689861	148332569	29	32177											
DNAH1	25981	broad.mit.edu	37	chr3	52383302	52383302	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agatcctggacagctcgctgCccagcagcatcatcattggg	9	8	11	13	1	2	1	2	0	0	1	4	2	3	2	2	2	4	4	2	2	0	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:52383302C>G	uc011bef.1	+	14	2653	c.2392C>G	c.(2392-2394)CCC>GCC	p.P798A	DNAH1_uc003ddt.1_Missense_Mutation_p.P798A	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	798	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CAGCTCGCTGCCCAGCAGCAT	0.592													20	8					0	0	0	0	G	52383302	G	G	52383302	3	3	171	1	0	0	0	0	1	0	0	0	4619	739	26	4	2442	4	DNAH1	3	52383302	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	2693441	52383302	145639128	30	32178											
C3orf63	23272	broad.mit.edu	37	chr3	56667140	56667140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcacagtatttttctggaCgtctttcatgattttaacca	9	19	5	8	1	4	1	2	1	2	0	4	2	4	2	1	1	1	1	1	1	2	7			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:56667140C>T	uc003did.3	-	17	3597	c.3496G>A	c.(3496-3498)GTC>ATC	p.V1166I	C3orf63_uc003dib.3_Missense_Mutation_p.V285I|C3orf63_uc003dic.3_Missense_Mutation_p.V790I|C3orf63_uc003die.3_Missense_Mutation_p.V1227I	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1227										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		TTTTTCTGGACGTCTTTCATG	0.328													30	18					0	0	0	0	T	56667140	T	T	56667140	3	4	171	1	0	0	0	0	1	0	0	0	2249	536	19	1	1421	1	C3orf63	3	56667140	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	4283838	56667140	141355290	31	32179											
IMPG2	50939	broad.mit.edu	37	chr3	101038496	101038496	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcatctgggcagattttcActccattaggaaacagaata	13	13	7	8	0	3	2	2	0	1	2	4	3	4	3	1	2	1	1	1	2	4	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:101038496A>T	uc003duq.1	-	2	469	c.266T>A	c.(265-267)GTG>GAG	p.V89E	IMPG2_uc011bhe.1_5'UTR	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	89	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GCAGATTTTCACTCCATTAGG	0.433													67	30					0	0	0	0	T	101038496	T	T	101038496	3	4	171	1	0	0	0	0	1	0	0	0	7768	159	6	5	3531	5	IMPG2	3	101038496	Missense_Mutation	SNP	A	TCGA-CV-5434-01A-01D-1683-08	44371356	101038496	96983934	32	32180											
CBLB	868	broad.mit.edu	37	chr3	105456100	105456100	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctcccatcaggataaagaTaactgaatttaaacagaaac	18	9	5	9	0	1	3	1	1	0	2	3	4	3	4	2	1	3	0	2	1	7	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:105456100T>C	uc003dwc.2	-	8	1308	c.986A>G	c.(985-987)TAT>TGT	p.Y329C	CBLB_uc011bhi.1_Missense_Mutation_p.Y351C|CBLB_uc003dwd.1_Missense_Mutation_p.Y329C|CBLB_uc003dwe.1_Missense_Mutation_p.Y329C|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	329	Cbl-PTB.|SH2-like.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						AGGATAAAGATAACTGAATTT	0.279			Mis S		AML								25	15					0	0	0	0	C	105456100	C	C	105456100	3	2	171	1	0	0	0	0	1	0	0	0	2713	1406	49	5	2010	5	CBLB	3	105456100	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	4417604	105456100	92566330	33	32181											
PLCH1	23007	broad.mit.edu	37	chr3	155199373	155199373	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagacttttggatttgcaaGgactaggcagtttcagagca	11	11	11	8	0	1	2	1	0	0	2	1	4	1	4	1	3	2	4	1	3	2	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:155199373G>T	uc011bok.1	-	23	4743	c.4466C>A	c.(4465-4467)CCT>CAT	p.P1489H	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.P1451H	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1489					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGATTTGCAAGGACTAGGCAG	0.468													13	59					6.31663e-08	6.72927e-08	1	0	T	155199373	T	T	155199373	3	4	171	1	0	0	0	0	1	0	0	0	12092	1000	35	4	619	4	PLCH1	3	155199373	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	49743273	155199373	42823057	34	32182											
SLITRK3	22865	broad.mit.edu	37	chr3	164906141	164906141	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accgtcactatggtgttaagCtgggagctggacactgctag	9	10	13	9	1	1	0	1	0	0	0	1	2	1	2	1	3	3	4	1	3	3	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:164906141C>A	uc003fej.3	-	2	2922	c.2478G>T	c.(2476-2478)CAG>CAT	p.Q826H	SLITRK3_uc003fek.2_Missense_Mutation_p.Q826H	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	826	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TGGTGTTAAGCTGGGAGCTGG	0.547										HNSCC(40;0.11)			39	73					6.02501e-08	6.45102e-08	1	0	A	164906141	A	A	164906141	3	1	171	1	0	0	0	0	1	0	0	0	14808	796	28	4	459	4	SLITRK3	3	164906141	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	9706768	164906141	33116289	35	32183											
SLITRK3	22865	broad.mit.edu	37	chr3	164906887	164906887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actgactgagctgatggtttCgatccactgtttaaagggga	10	12	12	7	1	0	3	0	3	0	0	2	5	1	4	1	3	1	3	1	3	2	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:164906887C>T	uc003fej.3	-	2	2176	c.1732G>A	c.(1732-1734)GAA>AAA	p.E578K	SLITRK3_uc003fek.2_Missense_Mutation_p.E578K	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	578	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CTGATGGTTTCGATCCACTGT	0.517										HNSCC(40;0.11)			6	69					0	0	0	0	T	164906887	T	T	164906887	3	4	171	1	0	0	0	0	1	0	0	0	14808	893	31	1	1205	1	SLITRK3	3	164906887	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	746	164906887	33115543	36	32184											
MECOM	2122	broad.mit.edu	37	chr3	168838896	168838896	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgttgtttgaggcccgaCgaagtggcaaacgttttgcc	7	13	13	8	3	0	1	0	1	0	0	0	3	0	1	2	2	2	4	2	2	2	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr3:168838896C>A	uc003ffi.3	-	6	785	c.516G>T	c.(514-516)TCG>TCT	p.S172S	MECOM_uc010hwk.1_Silent_p.S195S|MECOM_uc003ffj.3_Silent_p.S237S|MECOM_uc011bpi.1_Silent_p.S173S|MECOM_uc003ffn.3_Silent_p.S172S|MECOM_uc003ffk.2_Silent_p.S172S|MECOM_uc003ffl.2_Silent_p.S332S|MECOM_uc011bpj.1_Silent_p.S360S|MECOM_uc011bpk.1_Silent_p.S162S|MECOM_uc010hwn.2_Silent_p.S360S	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	172	C2H2-type 5.|Interaction with MAPK9, SMAD3 and probably SUV39H1.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TGAGGCCCGACGAAGTGGCAA	0.552													19	39					5.03518e-11	5.47415e-11	1	0	A	168838896	A	A	168838896	2	1	171	1	0	0	0	0	0	0	0	1	9475	523	19	3		3	MECOM	3	168838896	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08	3932009	168838896	29183534	37	32185											
GABRB1	2560	broad.mit.edu	37	chr4	47428009	47428009	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttttctctttttaatgtcGtctattggctttactatgta	6	22	5	8	1	2	0	0	0	2	0	4	0	2	0	1	1	1	2	1	1	5	11			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr4:47428009G>T	uc003gxh.2	+	9	1773	c.1399G>T	c.(1399-1401)GTC>TTC	p.V467F	GABRB1_uc011bze.1_Missense_Mutation_p.V397F	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	467	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTTTAATGTCGTCTATTGGCT	0.418													46	27					8.04919e-23	9.17434e-23	1	0	T	47428009	T	T	47428009	3	4	171	1	0	0	0	0	1	0	0	0	6200	1145	40	3	1433	3	GABRB1	4	47428009	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08		47428009	143726267	38	32186											
PF4V1	5197	broad.mit.edu	37	chr4	74719102	74719102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctccgcagccaggtcccGcctcacccgcgccacccgcc	5	3	10	23	5	1	0	1	0	0	0	3	1	3	0	8	1	2	2	8	1	0	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr4:74719102G>A	uc003hhg.1	+	1	90	c.23G>A	c.(22-24)CGC>CAC	p.R8H		NM_002620	NP_002611	P10720	PF4V_HUMAN	platelet factor 4 variant 1	8					immune response	extracellular region	chemokine activity|heparin binding				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GCCAGGTCCCGCCTCACCCGC	0.652													3	11					0	0	0	0	A	74719102	A	A	74719102	3	1	171	1	0	0	0	0	1	0	0	0	11808	1087	38	1	25	1	PF4V1	4	74719102	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	27291093	74719102	116435174	39	32187											
SCLT1	132320	broad.mit.edu	37	chr4	130014244	130014244	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctttgctctctcagaaagtcGatttctgcagccatttcgat	8	15	7	11	2	3	1	1	0	2	1	6	3	3	1	1	0	3	2	1	0	1	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr4:130014244G>C	uc003igp.2	-	1	521	c.15C>G	c.(13-15)ATC>ATG	p.I5M	C4orf33_uc010ioc.1_5'Flank|C4orf33_uc003igu.3_5'Flank|SCLT1_uc003igq.2_Missense_Mutation_p.I5M|SCLT1_uc010iob.1_Missense_Mutation_p.I5M|SCLT1_uc003igr.2_Missense_Mutation_p.I5M|SCLT1_uc003igs.2_Intron|SCLT1_uc003igt.3_Missense_Mutation_p.I5M	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	5						centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						TCAGAAAGTCGATTTCTGCAG	0.383													29	15					0	0	0	0	C	130014244	C	C	130014244	3	2	171	1	0	0	0	0	1	0	0	0	13971	1048	37	3	2135	3	SCLT1	4	130014244	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	55295142	130014244	61140032	40	32188											
SLC7A11	23657	broad.mit.edu	37	chr4	139103507	139103507	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacatgaatcatggagaggaTttctggaaggtgaccctctc	11	10	12	8	0	3	3	1	2	2	1	4	7	3	5	1	4	0	0	1	4	2	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr4:139103507T>C	uc011chb.1	-	9	1340	c.1060A>G	c.(1060-1062)ATC>GTC	p.I354V		NM_014331	NP_055146	Q9UPY5	XCT_HUMAN	solute carrier family 7, (cationic amino acid	354	Cytoplasmic (Potential).				blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			skin(1)	1	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	ATGGAGAGGATTTCTGGAAGG	0.393													16	8					0	0	0	0	C	139103507	C	C	139103507	3	2	171	1	0	0	0	0	1	0	0	0	14758	1493	52	5	461	5	SLC7A11	4	139103507	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	9089263	139103507	52050769	41	32189											
PRSS48	345062	broad.mit.edu	37	chr4	152212572	152212572	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcatacagggctgggaagaGaatgcatggagatttagtcc	12	9	14	6	0	0	2	0	0	0	2	1	5	1	3	1	3	3	3	1	3	4	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr4:152212572G>C	uc011cif.1	+	5	954	c.954G>C	c.(952-954)GAG>GAC	p.E318D	PRSS48_uc011cig.1_Missense_Mutation_p.E175D	NM_183375	NP_899231	Q7RTY5	PRS48_HUMAN	epidermis-specific serine protease-like protein	318					proteolysis	extracellular region	serine-type endopeptidase activity			large_intestine(1)	1						GCTGGGAAGAGAATGCATGGA	0.473													16	6					0	0	0	0	C	152212572	C	C	152212572	3	2	171	1	0	0	0	0	1	0	0	0	12692	933	33	2	972	2	PRSS48	4	152212572	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	13109065	152212572	38941704	42	32190											
FSTL5	56884	broad.mit.edu	37	chr4	162307172	162307172	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtttgtgtgcttgaactaccGtagatgttatattggtgggc	7	16	13	5	1	0	2	0	1	0	1	0	2	0	2	1	2	3	4	1	2	5	7			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr4:162307172G>A	uc003iqh.2	-	16	2707	c.2271C>T	c.(2269-2271)TAC>TAT	p.Y757Y	FSTL5_uc003iqi.2_Silent_p.Y756Y|FSTL5_uc010iqv.2_Silent_p.Y747Y|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	757						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTGAACTACCGTAGATGTTAT	0.418													4	69					0	0	0	0	A	162307172	A	A	162307172	2	1	171	1	0	0	0	0	0	0	0	1	6114	1140	40	1		1	FSTL5	4	162307172	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	10094600	162307172	28847104	43	32191											
FAT1	2195	broad.mit.edu	37	chr4	187524462	187524463	+	Nonsense_Mutation	DNP	CC	AA	AA																															cttccaggggcagtccagtcCcgcgcagagtttctggaata																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr4:187524462_187524463CC>AA	uc003izf.2	-	19	11405_11406	c.11217_11218GG>TT	c.(11215-11220)GCGGGA>GCTTGA	p.G3740*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3740	Extracellular (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CAGTCCAGTCCCGCGCAGAGTT	0.465										HNSCC(5;0.00058)			17	8					0	0	0	0	AA	187524463	AA	AA	187524462	4	1	171	1	0	0	0	0	0	1	0	0	5721	632	22	4	2584	4	FAT1	4	187524462	Nonsense_Mutation	DNP	CC	TCGA-CV-5434-01A-01D-1683-08	25217290	187524462	3629814	44	32192											
TRIML2	205860	broad.mit.edu	37	chr4	189022227	189022227	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacctgtagcatttcctggaAcatctcctctagctcggtgg	7	12	9	13	1	2	0	0	0	2	0	5	1	3	1	3	3	3	3	3	3	3	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr4:189022227A>G	uc003izl.2	-	3	349	c.313T>C	c.(313-315)TTC>CTC	p.F105L	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Missense_Mutation_p.F155L|TRIML2_uc011clf.1_Missense_Mutation_p.F155L	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	105	Potential.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		ATTTCCTGGAACATCTCCTCT	0.398													11	15					0	0	0	0	G	189022227	G	G	189022227	3	3	171	1	0	0	0	0	1	0	0	0	16618	43	2	5	870	5	TRIML2	4	189022227	Missense_Mutation	SNP	A	TCGA-CV-5434-01A-01D-1683-08	1497765	189022227	2132049	45	32193											
CDH9	1007	broad.mit.edu	37	chr5	26885873	26885873	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtgtaccagtgctgctttGaattggataatcgttgtcaa	10	14	11	6	1	1	1	1	1	0	0	2	3	1	2	1	1	3	4	1	1	4	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr5:26885873G>A	uc003jgs.1	-	11	1901	c.1732C>T	c.(1732-1734)CAA>TAA	p.Q578*	CDH9_uc011cnv.1_Nonsense_Mutation_p.Q171*	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	578	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GTGCTGCTTTGAATTGGATAA	0.458													5	24					0	0	0	0	A	26885873	A	A	26885873	4	1	171	1	0	0	0	0	0	1	0	0	3132	1299	45	2	645	2	CDH9	5	26885873	Nonsense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08		26885873	154029387	46	32194											
MAST4	375449	broad.mit.edu	37	chr5	66426148	66426148	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagcaggcctttgtggagcGggatatcctgacttttgcag	7	11	13	10	1	0	1	0	1	0	0	1	3	1	3	3	3	3	2	3	3	1	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr5:66426148G>A	uc003jut.1	+	14	1357	c.1289G>A	c.(1288-1290)CGG>CAG	p.R430Q	MAST4_uc003juu.1_Missense_Mutation_p.R440Q|MAST4_uc011cra.1_Missense_Mutation_p.R413Q|MAST4_uc003juv.2_Missense_Mutation_p.R425Q|MAST4_uc003juw.2_Missense_Mutation_p.R425Q	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	622	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TTTGTGGAGCGGGATATCCTG	0.458													20	19					0	0	0	0	A	66426148	A	A	66426148	3	1	171	1	0	0	0	0	1	0	0	0	9380	1116	39	1	2044	1	MAST4	5	66426148	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	39540275	66426148	114489112	47	32195											
RAD50	10111	broad.mit.edu	37	chr5	131915147	131915147	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctaattggcctttaagtgaAggaaaggctttgaagcaaaa	15	11	10	5	0	1	2	0	2	1	0	1	3	1	3	1	3	1	2	1	3	7	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr5:131915147A>G	uc003kxi.2	+	4	891	c.504A>G	c.(502-504)GAA>GAG	p.E168E	RAD50_uc003kxg.1_Silent_p.E69E|RAD50_uc003kxh.2_Silent_p.E29E	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	168					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTTAAGTGAAGGAAAGGCTT	0.348								Homologous_recombination					44	11					0	0	0	0	G	131915147	G	G	131915147	2	3	171	1	0	0	0	0	0	0	0	1	13049	69	3	5		5	RAD50	5	131915147	Silent	SNP	A	TCGA-CV-5434-01A-01D-1683-08	65488999	131915147	49000113	48	32196											
PCDHA7	56141	broad.mit.edu	37	chr5	140215594	140215594	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcgcgcgatgcgggcgtGccgcctctgggcagcaacgt	5	5	17	14	8	1	0	0	0	1	0	1	1	1	0	2	2	5	2	2	2	1	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr5:140215594G>T	uc003lhq.2	+	1	1626	c.1626G>T	c.(1624-1626)GTG>GTT	p.V542V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.V542V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	542	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCGGGCGTGCCGCCTCTGG	0.692													51	67					8.72198e-27	1.00492e-26	1	0	T	140215594	T	T	140215594	2	4	171	1	0	0	0	0	0	0	0	1	11583	1306	46	4		4	PCDHA7	5	140215594	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	8300447	140215594	40699666	49	32197											
PCDHB11	56125	broad.mit.edu	37	chr5	140580973	140580973	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcggctccccggctttgagCagcgaggcgctggtgcgcgt	3	7	17	14	7	0	1	0	1	0	0	1	2	1	1	2	4	3	4	2	4	0	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr5:140580973C>T	uc003liy.2	+	1	1626	c.1626C>T	c.(1624-1626)AGC>AGT	p.S542S	PCDHB11_uc011daj.1_Silent_p.S177S	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	542	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGCTTTGAGCAGCGAGGCGC	0.692													31	21					0	0	0	0	T	140580973	T	T	140580973	2	4	171	1	0	0	0	0	0	0	0	1	11590	709	25	4		4	PCDHB11	5	140580973	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08	365379	140580973	40334287	50	32198											
FOXF2	2295	broad.mit.edu	37	chr6	1395022	1395022	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatttcttctttccatccCtcagctagcgggtcgtatta	6	15	9	11	2	3	0	1	0	2	0	6	1	5	1	2	2	2	2	2	2	3	6			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr6:1395022C>T	uc003mtm.2	+	2	1377	c.1263C>T	c.(1261-1263)CCC>CCT	p.P421P	FOXF2_uc003mtn.2_Intron	NM_001452	NP_001443	Q12947	FOXF2_HUMAN	forkhead box F2	421					epithelial to mesenchymal transition|genitalia development|palate development|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0	Ovarian(93;0.0733)	all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.095)		CTTTCCATCCCTCAGCTAGCG	0.507													25	45					0	0	0	0	T	1395022	T	T	1395022	2	4	171	1	0	0	0	0	0	0	0	1	6040	668	24	4		4	FOXF2	6	1395022	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08		1395022	169720045	51	32199											
CCHCR1	54535	broad.mit.edu	37	chr6	31113227	31113227	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagtgcccaaacttcacctCtcctggcgcagctgagcaag	11	7	9	14	1	2	1	1	1	1	0	3	1	2	1	3	1	4	3	3	1	3	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr6:31113227C>G	uc003nsr.3	-	12	1593	c.1470G>C	c.(1468-1470)GAG>GAC	p.E490D	CCHCR1_uc011dne.1_Missense_Mutation_p.E490D|CCHCR1_uc003nsq.3_Missense_Mutation_p.E543D|CCHCR1_uc003nsp.3_Missense_Mutation_p.E579D|CCHCR1_uc010jsk.1_Missense_Mutation_p.E490D	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	490					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						AACTTCACCTCTCCTGGCGCA	0.557													6	31					0	0	0	0	G	31113227	G	G	31113227	3	3	171	1	0	0	0	0	1	0	0	0	2890	912	32	2	906	2	CCHCR1	6	31113227	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	29718205	31113227	140001840	52	32200											
FGD2	221472	broad.mit.edu	37	chr6	36993640	36993640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggcccaaccgagtctgcCtccactgctacgcattcctc	8	8	7	18	2	1	0	0	0	1	0	4	1	3	0	5	1	4	2	5	1	2	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr6:36993640C>T	uc010jwp.1	+	14	1702	c.1531C>T	c.(1531-1533)CTC>TTC	p.L511F	FGD2_uc003ong.2_Missense_Mutation_p.L233F|FGD2_uc011dtv.1_Missense_Mutation_p.L139F|FGD2_uc003onj.1_Missense_Mutation_p.L88F	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	511	FYVE-type.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						CCGAGTCTGCCTCCACTGCTA	0.622													36	7					0	0	0	0	T	36993640	T	T	36993640	3	4	171	1	0	0	0	0	1	0	0	0	5865	681	24	4	1585	4	FGD2	6	36993640	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	5880413	36993640	134121427	53	32201											
ZNF451	26036	broad.mit.edu	37	chr6	56997884	56997884	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggaacaaaaagttcattcCgaagaggaggccacacgtgg	14	6	13	8	2	1	1	1	0	0	1	2	4	2	3	2	4	1	1	2	4	4	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr6:56997884C>T	uc003pdm.1	+	6	693	c.469C>T	c.(469-471)CGA>TGA	p.R157*	ZNF451_uc003pdl.2_Nonsense_Mutation_p.R157*|ZNF451_uc003pdn.1_Nonsense_Mutation_p.R157*|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Nonsense_Mutation_p.R157*	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AAGTTCATTCCGAAGAGGAGG	0.393													15	44					0	0	0	0	T	56997884	T	T	56997884	4	4	171	1	0	0	0	0	0	1	0	0	17989	644	23	1	491	1	ZNF451	6	56997884	Nonsense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	20004244	56997884	114117183	54	32202											
SH3BGRL2	83699	broad.mit.edu	37	chr6	80406206	80406206	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttccctttttttctaggattAtgacagtttttttgaatcca	8	21	5	7	0	1	2	0	2	1	0	3	3	3	3	2	1	0	1	2	1	3	9			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr6:80406206A>T	uc003piz.1	+	3	415	c.236A>T	c.(235-237)TAT>TTT	p.Y79F		NM_031469	NP_113657	Q9UJC5	SH3L2_HUMAN	SH3 domain binding glutamic acid-rich protein	79						nucleus	SH3 domain binding				0		all_cancers(76;0.00188)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.174)		BRCA - Breast invasive adenocarcinoma(397;0.0278)		TTCTAGGATTATGACAGTTTT	0.308													42	19					0	0	0	0	T	80406206	T	T	80406206	3	4	171	1	0	0	0	0	1	0	0	0	14307	449	16	5	246	5	SH3BGRL2	6	80406206	Missense_Mutation	SNP	A	TCGA-CV-5434-01A-01D-1683-08	23408322	80406206	90708861	55	32203											
MCHR2	84539	broad.mit.edu	37	chr6	100382303	100382303	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttattctgttgatacatCtcccaagtatagcataaaat	13	15	4	9	0	2	1	0	1	2	0	4	1	3	1	2	0	2	3	2	0	7	7			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr6:100382303C>A	uc003pqh.1	-	5	993	c.678G>T	c.(676-678)GAG>GAT	p.E226D	MCHR2_uc003pqi.1_Missense_Mutation_p.E226D	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	226	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		GTTGATACATCTCCCAAGTAT	0.303													14	54					1.5842e-08	1.70482e-08	1	0	A	100382303	A	A	100382303	3	1	171	1	0	0	0	0	1	0	0	0	9436	912	32	2	352	2	MCHR2	6	100382303	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	19976097	100382303	70732764	56	32204											
LAMA2	3908	broad.mit.edu	37	chr6	129637295	129637295	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcttatcaaagctacttatgGaaatttcatgcgacaaagca	15	12	6	8	1	3	0	2	0	1	0	3	2	3	1	0	1	4	2	0	1	6	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr6:129637295G>A	uc003qbn.2	+	27	4142	c.4037G>A	c.(4036-4038)GGA>GAA	p.G1346E	LAMA2_uc003qbo.2_Missense_Mutation_p.G1346E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1346	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCTACTTATGGAAATTTCATG	0.343													14	15					0	0	0	0	A	129637295	A	A	129637295	3	1	171	1	0	0	0	0	1	0	0	0	8646	1174	41	2	4143	2	LAMA2	6	129637295	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	29254992	129637295	41477772	57	32205											
TMEM184A	202915	broad.mit.edu	37	chr7	1590490	1590490	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acagagtcgaagtagacgtaGtactggtggtctccgaggag	11	8	15	7	3	1	2	0	0	1	2	3	5	1	3	1	3	1	3	1	3	4	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:1590490G>T	uc003skv.3	-	3	665	c.348C>A	c.(346-348)TAC>TAA	p.Y116*	TMEM184A_uc003skt.3_5'UTR|TMEM184A_uc003skw.3_5'UTR	NM_001097620	NP_001091089	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	116						integral to membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		AGTAGACGTAGTACTGGTGGT	0.642													33	20					7.63505e-26	8.74935e-26	1	0	T	1590490	T	T	1590490	4	4	171	1	0	0	0	0	0	1	0	0	16170	1024	36	4	921	4	TMEM184A	7	1590490	Nonsense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08		1590490	157548173	58	32206											
GLCCI1	113263	broad.mit.edu	37	chr7	8126118	8126118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcagcagcagctcctgcagGaactgcagggtgaggaccac	11	4	14	12	0	0	1	0	1	0	0	1	3	1	3	2	3	7	6	2	3	1	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:8126118G>A	uc003srk.2	+	8	2153	c.1594G>A	c.(1594-1596)GAA>AAA	p.E532K		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	532											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		GCTCCTGCAGGAACTGCAGGG	0.547													49	152					0	0	0	0	A	8126118	A	A	8126118	3	1	171	1	0	0	0	0	1	0	0	0	6468	1175	41	2	1624	2	GLCCI1	7	8126118	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	6535628	8126118	151012545	59	32207											
MPP6	51678	broad.mit.edu	37	chr7	24705286	24705286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagagaaaggcatttgttaGaagagactgggacaattcag	16	8	13	4	0	1	3	1	0	0	3	1	7	1	4	0	2	0	2	0	2	5	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:24705286G>A	uc003swx.2	+	8	1162	c.863G>A	c.(862-864)AGA>AAA	p.R288K	MPP6_uc003swy.2_Missense_Mutation_p.R288K|MPP6_uc010kur.2_5'Flank	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	288					protein complex assembly		protein binding				0						GCATTTGTTAGAAGAGACTGG	0.413													23	17					0	0	0	0	A	24705286	A	A	24705286	3	1	171	1	0	0	0	0	1	0	0	0	9791	942	33	2	885	2	MPP6	7	24705286	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	16579168	24705286	134433377	60	32208											
GPR141	353345	broad.mit.edu	37	chr7	37780320	37780320	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttcctattctatgtggtgAtcctggtcaccagatacctc	7	14	8	12	1	2	2	1	1	1	1	5	2	4	2	4	2	1	1	4	2	3	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:37780320A>G	uc003tfm.1	+	1	325	c.325A>G	c.(325-327)ATC>GTC	p.I109V	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	109	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						CTATGTGGTGATCCTGGTCAC	0.483													17	58					0	0	0	0	G	37780320	G	G	37780320	3	3	171	1	0	0	0	0	1	0	0	0	6687	333	12	5	327	5	GPR141	7	37780320	Missense_Mutation	SNP	A	TCGA-CV-5434-01A-01D-1683-08	13075034	37780320	121358343	61	32209											
MAGI2	9863	broad.mit.edu	37	chr7	78636417	78636417	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtactcacatggcaccgtgCggaggtagaggttgtcacga	9	9	14	9	3	2	1	2	0	0	1	2	3	2	2	1	4	2	4	1	4	2	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:78636417C>T	uc003ugx.2	-	2	661	c.407G>A	c.(406-408)CGC>CAC	p.R136H	MAGI2_uc003ugy.2_Missense_Mutation_p.R136H	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	136	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGGCACCGTGCGGAGGTAGAG	0.373													63	41					0	0	0	0	T	78636417	T	T	78636417	3	4	171	1	0	0	0	0	1	0	0	0	9244	768	27	1	4044	1	MAGI2	7	78636417	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	40856097	78636417	80502246	62	32210											
CCDC132	55610	broad.mit.edu	37	chr7	92979233	92979234	+	Missense_Mutation	DNP	TA	GT	GT																															gaaaccaatttactggattgTagctggtaaagcccttgatt																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:92979233_92979234TA>GT	uc003umo.2	+	25	2479_2480	c.2351_2352TA>GT	c.(2350-2352)GTA>GGT	p.V784G	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.V754G|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.V504G	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	784											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TACTGGATTGTAGCTGGTAAAG	0.342													16	88					0	0	0	0	GT	92979234	GT	GT	92979233	3	3	171	1	0	0	0	0	1	0	0	0	2779	1638	57	5	2491	5	CCDC132	7	92979233	Missense_Mutation	DNP	TA	TCGA-CV-5434-01A-01D-1683-08	14342816	92979233	66159430	63	32211											
ASB4	51666	broad.mit.edu	37	chr7	95157520	95157520	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccatccagtacgtgctgaagGtcacctccgtgcgccctgct	6	9	10	16	3	1	1	1	1	0	0	3	1	3	1	5	1	4	3	5	1	2	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:95157520G>C	uc011kij.1	+	3	883	c.883G>C	c.(883-885)GTC>CTC	p.V295L	ASB4_uc003unx.2_Missense_Mutation_p.V295L	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	295					intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			CGTGCTGAAGGTCACCTCCGT	0.572											OREG0018172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	51					0	0	0	0	C	95157520	C	C	95157520	3	2	171	1	0	0	0	0	1	0	0	0	1027	1261	44	4	893	4	ASB4	7	95157520	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	2178287	95157520	63981143	64	32212											
TMEM130	222865	broad.mit.edu	37	chr7	98446238	98446238	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttttgctgagtggcattccGcagggtcatgtacatgatga	8	13	12	8	1	1	3	1	3	0	0	2	3	2	3	1	2	2	4	1	2	1	4	rs142570247		TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:98446238G>T	uc003upo.2	-	7	1276	c.1087C>A	c.(1087-1089)CGG>AGG	p.R363R	TMEM130_uc011kiq.1_Silent_p.R344R|TMEM130_uc011kir.1_Silent_p.R363R|TMEM130_uc003upn.2_Silent_p.R261R	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	363	Cytoplasmic (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GTGGCATTCCGCAGGGTCATG	0.517													55	29					8.89271e-47	1.04158e-46	1	0	T	98446238	T	T	98446238	2	4	171	1	0	0	0	0	0	0	0	1	16109	1086	38	3		3	TMEM130	7	98446238	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	3288718	98446238	60692425	65	32213											
CYP3A5	1577	broad.mit.edu	37	chr7	99258197	99258197	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgagtggccagttcatataaAgtgaaggaaagaacactgct	15	9	11	6	0	1	3	1	2	0	1	1	4	1	4	1	2	2	2	1	2	6	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:99258197A>G	uc003urq.2	-	10	1038	c.951T>C	c.(949-951)ACT>ACC	p.T317T	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_Silent_p.T137T|CYP3A5_uc003urr.2_Silent_p.T204T|CYP3A5_uc011kiy.1_Silent_p.T307T|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	317					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	GTTCATATAAAGTGAAGGAAA	0.473													17	105					0	0	0	0	G	99258197	G	G	99258197	2	3	171	1	0	0	0	0	0	0	0	1	4197	59	3	5		5	CYP3A5	7	99258197	Silent	SNP	A	TCGA-CV-5434-01A-01D-1683-08	811959	99258197	59880466	66	32214											
GIGYF1	64599	broad.mit.edu	37	chr7	100285665	100285665	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cataacggtagtcagccagcTtgtatttgggcatggcaggg	9	10	14	8	1	1	0	1	0	0	0	1	0	1	0	1	4	3	5	1	4	3	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:100285665T>G	uc003uwg.1	-	2	1113	c.104A>C	c.(103-105)AAG>ACG	p.K35T		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	35										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GTCAGCCAGCTTGTATTTGGG	0.642													26	95					0	0	0	0	G	100285665	G	G	100285665	3	3	171	1	0	0	0	0	1	0	0	0	6414	1609	56	5	3095	5	GIGYF1	7	100285665	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	1027468	100285665	58852998	67	32215											
PIK3CG	5294	broad.mit.edu	37	chr7	106523581	106523581	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagtcctgaatcactggctCaaagaaaaatcccctactga	15	8	7	11	0	2	3	2	2	0	1	4	4	4	3	3	1	1	1	3	1	6	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:106523581C>T	uc003vdv.3	+	8	2818	c.2733C>T	c.(2731-2733)CTC>CTT	p.L911L	PIK3CG_uc003vdu.2_Silent_p.L911L|PIK3CG_uc003vdw.2_Silent_p.L911L	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	911	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						ATCACTGGCTCAAAGAAAAAT	0.428													5	153					0	0	0	0	T	106523581	T	T	106523581	2	4	171	1	0	0	0	0	0	0	0	1	11971	813	29	2		2	PIK3CG	7	106523581	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08	6237916	106523581	52615082	68	32216											
THAP5	168451	broad.mit.edu	37	chr7	108205290	108205290	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taactgatgtttccaaggtaGattctggtttcccagtatgt	9	16	9	7	0	1	2	0	1	1	1	3	2	3	2	2	2	1	4	2	2	4	6			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:108205290G>C	uc003vfm.2	-	3	687	c.533C>G	c.(532-534)TCT>TGT	p.S178C	THAP5_uc003vfl.2_Missense_Mutation_p.S136C	NM_001130475	NP_001123947	Q7Z6K1	THAP5_HUMAN	THAP domain containing 5 isoform 1	178					cell cycle|negative regulation of cell cycle	nucleus	DNA binding|metal ion binding|protease binding				0						TTCCAAGGTAGATTCTGGTTT	0.348													6	24					0	0	0	0	C	108205290	C	C	108205290	3	2	171	1	0	0	0	0	1	0	0	0	15913	942	33	2	658	2	THAP5	7	108205290	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	1681709	108205290	50933373	69	32217											
SLC13A1	6561	broad.mit.edu	37	chr7	122808429	122808429	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagaatcaaatttatgtaccTtttccaactccaccttgctt	12	15	3	11	0	1	1	1	0	0	1	3	1	3	1	4	0	3	2	4	0	6	7			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:122808429T>A	uc003vkm.2	-	6	684	c.659A>T	c.(658-660)AAG>ATG	p.K220M	SLC13A1_uc010lks.2_Translation_Start_Site	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	220						integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	TTTATGTACCTTTTCCAACTC	0.254													11	9					0	0	0	0	A	122808429	A	A	122808429	3	1	171	1	0	0	0	0	1	0	0	0	14456	1623	56	5	1168	5	SLC13A1	7	122808429	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	14603139	122808429	36330234	70	32218											
MGAM	8972	broad.mit.edu	37	chr7	141734603	141734603	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atgacctgagatggtccatcCctggcgtgcttgagttcaac	8	11	11	11	1	1	3	1	3	0	1	3	4	3	3	3	2	2	2	3	2	1	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:141734603C>A	uc003vwy.2	+	16	1975	c.1921C>A	c.(1921-1923)CCT>ACT	p.P641T		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	641	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ATGGTCCATCCCTGGCGTGCT	0.507													23	24					3.28513e-13	3.60853e-13	1	0	A	141734603	A	A	141734603	3	1	171	1	0	0	0	0	1	0	0	0	9594	623	22	4	1979	4	MGAM	7	141734603	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	18926174	141734603	17404060	71	32219											
ZNF775	285971	broad.mit.edu	37	chr7	150095175	150095176	+	Frame_Shift_Del	DEL	GC	-	-																															cgtgcagccccaaggaggagGcgcgctagtggactggacct																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr7:150095175_150095176delGC	uc003whf.1	+	3	1731_1732	c.1606_1607delGC	c.(1606-1608)GCGfs	p.A536fs	LOC728743_uc003whg.2_5'Flank	NM_173680	NP_775951	Q96BV0	ZN775_HUMAN	zinc finger protein 775	536					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAAGGAGGAGGCGCGCTAGTGG	0.693													---	---	---								-	150095176	-	-	150095175	7	5	171	1	0	1	0	1	0	0	0	0	18215	1203	42	0	1612	0	ZNF775	7	150095175	Frame_Shift_Del	DEL	GC	TCGA-CV-5434-01A-01D-1683-08	8360572	150095175	9043488	72	32220											
UBXN2B	137886	broad.mit.edu	37	chr8	59352288	59352288	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatacataaaacctagattGaggttcaaggcttttagtgg	14	12	10	5	0	1	2	1	1	0	1	1	3	1	2	1	3	2	2	1	3	7	7			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr8:59352288G>A	uc003xtl.2	+	6	752	c.630G>A	c.(628-630)TTG>TTA	p.L210L		NM_001077619	NP_001071087	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	210						cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				ovary(2)	2						AACCTAGATTGAGGTTCAAGG	0.378													6	65					0	0	0	0	A	59352288	A	A	59352288	2	1	171	1	0	0	0	0	0	0	0	1	16983	1281	45	2		2	UBXN2B	8	59352288	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08		59352288	87011734	73	32221											
CSPP1	79848	broad.mit.edu	37	chr8	68076024	68076024	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccaggaaaaatcagctcCgtgcagaaggtagagttaac	14	7	11	9	1	1	2	1	0	0	2	2	3	2	3	2	2	4	4	2	2	5	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr8:68076024C>T	uc003xxi.2	+	23	2822	c.2791C>T	c.(2791-2793)CGT>TGT	p.R931C	CSPP1_uc003xxj.2_Missense_Mutation_p.R896C|CSPP1_uc003xxk.2_Missense_Mutation_p.R551C|CSPP1_uc010lyw.2_5'Flank	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	931	Potential.					centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAATCAGCTCCGTGCAGAAGG	0.338													11	27					0	0	0	0	T	68076024	T	T	68076024	3	4	171	1	0	0	0	0	1	0	0	0	3979	652	23	1	2881	1	CSPP1	8	68076024	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	8723736	68076024	78287998	74	32222											
GDAP1	54332	broad.mit.edu	37	chr8	75276509	75276509	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acgacccttgtggttggtttGcttgcaggagtgggatattt	6	15	14	6	1	0	0	0	0	0	0	0	3	0	2	1	4	2	4	1	4	1	6			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr8:75276509G>A	uc003yah.2	+	6	1063	c.984G>A	c.(982-984)TTG>TTA	p.L328L	GDAP1_uc011lfj.1_Silent_p.L213L|GDAP1_uc003yai.2_Silent_p.L260L	NM_018972	NP_061845	Q8TB36	GDAP1_HUMAN	ganglioside-induced differentiation-associated	328						cytoplasm					0	Breast(64;0.00769)	Myeloproliferative disorder(644;0.0122)	BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.104)|all cancers(69;0.234)			TGGTTGGTTTGCTTGCAGGAG	0.433													21	46					0	0	0	0	A	75276509	A	A	75276509	2	1	171	1	0	0	0	0	0	0	0	1	6343	1310	46	4		4	GDAP1	8	75276509	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	7200485	75276509	71087513	75	32223											
ZNF572	137209	broad.mit.edu	37	chr8	125990080	125990080	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcatctcttcattttccGtctcaaattcatcttcctga	7	18	2	14	1	6	1	4	1	3	0	10	1	8	1	3	0	0	0	3	0	1	6			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr8:125990080G>A	uc003yrr.2	+	3	1725	c.1570G>A	c.(1570-1572)GTC>ATC	p.V524I		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TTCATTTTCCGTCTCAAATTC	0.428										HNSCC(60;0.17)			39	49					0	0	0	0	A	125990080	A	A	125990080	3	1	171	1	0	0	0	0	1	0	0	0	18071	1145	40	1	1576	1	ZNF572	8	125990080	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	50713571	125990080	20373942	76	32224											
OC90	729330	broad.mit.edu	37	chr8	133062254	133062255	+	5'Flank	INS	-	T	T																															atatgactgcattataagggINStttttttgtccaacaggcct																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr8:133062254_133062255insT	uc003ytg.2	-						OC90_uc011lix.1_Intron	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90						lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CATTATAAgggtttttttgtcc	0.153													---	---	---								T	133062255	T	T	133062254	6	5	171	0	1	1	1	0	0	0	0	0	10868	1276	44	0		0	OC90	8	133062254	5'Flank	INS	-	TCGA-CV-5434-01A-01D-1683-08	7072174	133062254	13301768	77	32225											
TSTA3	7264	broad.mit.edu	37	chr8	144697068	144697068	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgcaggacgttgtcgttCatgtgcacgtttttcctctg	5	15	12	9	3	2	0	1	0	1	0	4	2	3	1	1	1	2	5	1	1	0	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr8:144697068C>A	uc003yza.2	-	4	315	c.279G>T	c.(277-279)ATG>ATT	p.M93I	TSTA3_uc003yzb.2_Missense_Mutation_p.M93I|TSTA3_uc011lko.1_Missense_Mutation_p.M93I	NM_003313	NP_003304	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	93					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			pancreas(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	CGTTGTCGTTCATGTGCACGT	0.607													21	62					5.45024e-15	6.1135e-15	1	0	A	144697068	A	A	144697068	3	1	171	1	0	0	0	0	1	0	0	0	16741	826	29	2	718	2	TSTA3	8	144697068	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	11634814	144697068	1666954	78	32226											
ZNF707	286075	broad.mit.edu	37	chr8	144776666	144776666	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacctggggttcttcacgcGgcatcagaggactcacaggc	8	8	12	13	2	5	1	4	0	1	1	5	2	5	2	1	5	0	2	1	5	0	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr8:144776666G>A	uc003yze.3	+	7	1397	c.1082G>A	c.(1081-1083)CGG>CAG	p.R361Q	ZNF707_uc010mfh.2_Missense_Mutation_p.R361Q|ZNF707_uc010mfi.2_Missense_Mutation_p.R361Q|ZNF707_uc003yzf.3_Missense_Mutation_p.R361Q|ZNF707_uc003yzh.3_Missense_Mutation_p.R288Q|ZNF707_uc011lkq.1_RNA|BREA2_uc010mfj.1_5'Flank	NM_173831	NP_776192	Q96C28	ZN707_HUMAN	zinc finger protein 707	361	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;5.6e-41)|Epithelial(56;1.02e-39)|all cancers(56;9.65e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TTCTTCACGCGGCATCAGAGG	0.647													25	16					0	0	0	0	A	144776666	A	A	144776666	3	1	171	1	0	0	0	0	1	0	0	0	18178	1116	39	1	1096	1	ZNF707	8	144776666	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	79598	144776666	1587356	79	32227											
HAUS6	54801	broad.mit.edu	37	chr9	19063008	19063008	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attacagtcttttctcacctCttctaccagatgatcttgct	8	17	4	12	0	5	2	1	1	5	1	6	2	5	2	2	0	3	1	2	0	2	6			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr9:19063008C>G	uc003znk.2	-	14	1880	c.1627G>C	c.(1627-1629)GAG>CAG	p.E543Q	HAUS6_uc011lmz.1_Missense_Mutation_p.E263Q|HAUS6_uc003znl.1_Missense_Mutation_p.E407Q|HAUS6_uc003znm.1_Missense_Mutation_p.E298Q	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	543					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle		p.E543K(1)		ovary(2)	2						TTTCTCACCTCTTCTACCAGA	0.264													43	138					0	0	0	0	G	19063008	G	G	19063008	3	3	171	1	0	0	0	0	1	0	0	0	7009	922	32	2	1256	2	HAUS6	9	19063008	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08		19063008	122150423	80	32228			1	48		3	3	97	C		1.390898e-07
HAUS6	54801	broad.mit.edu	37	chr9	19063029	19063029	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctaccagatgatcttgctCtttttgaaatggatcacttt	9	18	6	8	0	4	3	1	2	3	1	4	4	4	4	1	1	2	1	1	1	2	6			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr9:19063029C>G	uc003znk.2	-	14	1859	c.1606G>C	c.(1606-1608)GAG>CAG	p.E536Q	HAUS6_uc011lmz.1_Missense_Mutation_p.E256Q|HAUS6_uc003znl.1_Missense_Mutation_p.E400Q|HAUS6_uc003znm.1_Missense_Mutation_p.E291Q	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	536					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2						TGATCTTGCTCTTTTTGAAAT	0.299													57	159					0	0	0	0	G	19063029	G	G	19063029	3	3	171	1	0	0	0	0	1	0	0	0	7009	922	32	2	1277	2	HAUS6	9	19063029	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	21	19063029	122150402	81	32229			1	48		3	3	97	C		1.390898e-07
HAUS6	54801	broad.mit.edu	37	chr9	19063104	19063104	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgtattctttgcaacatCtgataatggagaattttcca	11	16	6	8	0	3	2	0	1	3	1	4	3	4	2	1	1	2	2	1	1	4	6			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr9:19063104C>T	uc003znk.2	-	14	1784	c.1531G>A	c.(1531-1533)GAT>AAT	p.D511N	HAUS6_uc011lmz.1_Missense_Mutation_p.D231N|HAUS6_uc003znl.1_Missense_Mutation_p.D375N|HAUS6_uc003znm.1_Missense_Mutation_p.D266N	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	511					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2						TTTGCAACATCTGATAATGGA	0.368													60	114					0	0	0	0	T	19063104	T	T	19063104	3	4	171	1	0	0	0	0	1	0	0	0	7009	913	32	2	1352	2	HAUS6	9	19063104	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	75	19063104	122150327	82	32230			1	48		3	3	97	C		1.390898e-07
UBAP2	55833	broad.mit.edu	37	chr9	33943473	33943473	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attactattttcactgcttgGagctgatccaaattcagaga	12	14	7	8	0	2	2	2	1	0	1	3	4	3	3	1	1	3	2	1	1	3	6	rs147087482		TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr9:33943473G>T	uc003ztq.1	-	15	1773	c.1660C>A	c.(1660-1662)CCA>ACA	p.P554T	UBAP2_uc011loc.1_Missense_Mutation_p.P463T|UBAP2_uc011lod.1_Missense_Mutation_p.P287T|UBAP2_uc011loe.1_Missense_Mutation_p.P309T|UBAP2_uc011lof.1_Missense_Mutation_p.P479T|UBAP2_uc011log.1_Missense_Mutation_p.P500T|UBAP2_uc003ztr.2_Missense_Mutation_p.P426T|UBAP2_uc003zts.2_Missense_Mutation_p.P187T	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	554										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TCACTGCTTGGAGCTGATCCA	0.408													17	67					3.70931e-20	4.20521e-20	1	0	T	33943473	T	T	33943473	3	4	171	1	0	0	0	0	1	0	0	0	16905	1174	41	2	1759	2	UBAP2	9	33943473	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	14880369	33943473	107269958	83	32231											
TRPM3	80036	broad.mit.edu	37	chr9	73164503	73164503	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catcattagatgagttgaacCgatcatccttttctctgaag	11	14	7	9	1	3	4	2	3	1	1	5	5	4	4	2	0	1	1	2	0	3	4	rs139956868	by1000genomes	TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr9:73164503C>A	uc004aid.2	-	24	3870	c.3626G>T	c.(3625-3627)CGG>CTG	p.R1209L	TRPM3_uc004ahu.2_Missense_Mutation_p.R1051L|TRPM3_uc004ahv.2_Missense_Mutation_p.R1011L|TRPM3_uc004ahw.2_Missense_Mutation_p.R1081L|TRPM3_uc004ahx.2_Missense_Mutation_p.R1068L|TRPM3_uc004ahy.2_Missense_Mutation_p.R1071L|TRPM3_uc004ahz.2_Missense_Mutation_p.R1058L|TRPM3_uc004aia.2_Missense_Mutation_p.R1056L|TRPM3_uc004aib.2_Missense_Mutation_p.R1046L|TRPM3_uc004aic.2_Missense_Mutation_p.R1209L	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1234	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TGAGTTGAACCGATCATCCTT	0.423													30	27					2.61193e-14	2.91437e-14	1	0	A	73164503	A	A	73164503	3	1	171	1	0	0	0	0	1	0	0	0	16654	652	23	3	1505	3	TRPM3	9	73164503	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	39221030	73164503	68048928	84	32232											
OR1N2	138882	broad.mit.edu	37	chr9	125316085	125316085	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctcagatacccatgtaaacGagctgatgatcatcaccatg	13	9	8	11	1	3	3	3	2	0	1	3	4	3	3	2	0	3	3	2	0	3	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr9:125316085G>A	uc011lyx.1	+	1	637	c.637G>A	c.(637-639)GAG>AAG	p.E213K		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	213	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						CCATGTAAACGAGCTGATGAT	0.517													92	61					0	0	0	0	A	125316085	A	A	125316085	3	1	171	1	0	0	0	0	1	0	0	0	11024	1059	37	1	639	1	OR1N2	9	125316085	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	52151582	125316085	15897346	85	32233											
PDCL	5082	broad.mit.edu	37	chr9	125585430	125585430	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctcctccctctgctctgtCtccaactgcttgaagcggcg	4	12	9	16	2	3	1	0	1	3	0	6	1	5	1	3	1	5	3	3	1	2	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr9:125585430C>G	uc004bmz.1	-	3	315	c.219G>C	c.(217-219)GAG>GAC	p.E73D	PDCL_uc004bna.2_Missense_Mutation_p.E73D	NM_005388	NP_005379	Q13371	PHLP_HUMAN	phosducin-like	73					signal transduction|visual perception						0						TCTGCTCTGTCTCCAACTGCT	0.537													29	124					0	0	0	0	G	125585430	G	G	125585430	3	3	171	1	0	0	0	0	1	0	0	0	11680	912	32	2	694	2	PDCL	9	125585430	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	269345	125585430	15628001	86	32234											
GAPVD1	26130	broad.mit.edu	37	chr9	128092450	128092450	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactggttctaccatatcagAgacaacaagtgaagcttgga	14	9	9	9	0	2	2	1	1	1	1	2	4	2	3	1	2	3	2	1	2	5	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr9:128092450A>G	uc010mwx.2	+	13	2452	c.2126A>G	c.(2125-2127)GAG>GGG	p.E709G	GAPVD1_uc011lzs.1_Missense_Mutation_p.E709G|GAPVD1_uc004bpp.2_Missense_Mutation_p.E709G|GAPVD1_uc004bpq.2_Missense_Mutation_p.E709G|GAPVD1_uc004bpr.2_Missense_Mutation_p.E688G|GAPVD1_uc004bps.2_Missense_Mutation_p.E709G|GAPVD1_uc010mwy.1_Missense_Mutation_p.E568G	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	709					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						ACCATATCAGAGACAACAAGT	0.433													32	98					0	0	0	0	G	128092450	G	G	128092450	3	3	171	1	0	0	0	0	1	0	0	0	6274	304	11	5	2164	5	GAPVD1	9	128092450	Missense_Mutation	SNP	A	TCGA-CV-5434-01A-01D-1683-08	2507020	128092450	13120981	87	32235											
KIAA0649	9858	broad.mit.edu	37	chr9	138376561	138376561	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaccagcgatgagcgcgccGcacagaggggccacagggca	10	1	16	14	4	0	2	0	1	0	1	0	3	0	2	3	3	2	3	3	3	0	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr9:138376561G>A	uc004cfr.1	+	4	754	c.205G>A	c.(205-207)GCA>ACA	p.A69T		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	69						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		TGAGCGCGCCGCACAGAGGGG	0.706													50	48					0	0	0	0	A	138376561	A	A	138376561	3	1	171	1	0	0	0	0	1	0	0	0	8226	1087	38	1	207	1	KIAA0649	9	138376561	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	10284111	138376561	2836870	88	32236											
AKR1C4	1109	broad.mit.edu	37	chr10	5247720	5247720	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agtgactgcttctacttcagCcaggtgagacgccactacca	10	9	9	13	1	2	2	1	2	1	1	2	3	2	2	3	1	4	1	3	1	2	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr10:5247720C>A	uc001ihw.2	+	4	403	c.370C>A	c.(370-372)CCA>ACA	p.P124T		NM_001818	NP_001809	P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	124					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			ovary(1)	1					NADH(DB00157)	TCTACTTCAGCCAGGTGAGAC	0.448													20	4					1.00905e-13	1.11416e-13	1	0	A	5247720	A	A	5247720	3	1	171	1	0	0	0	0	1	0	0	0	472	753	26	4	384	4	AKR1C4	10	5247720	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08		5247720	130287027	89	32237											
GPRIN2	9721	broad.mit.edu	37	chr10	46999984	46999984	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgttcccagaggtaactctGgggtccagcctggaggaggt	7	9	16	9	0	1	1	0	0	1	1	3	3	3	3	3	6	2	2	3	6	1	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr10:46999984G>T	uc001jec.2	+	3	1239	c.1104G>T	c.(1102-1104)CTG>CTT	p.L368L	GPRIN2_uc010qfq.1_Silent_p.L131L	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	368											0						AGGTAACTCTGGGGTCCAGCC	0.672													10	85					7.48243e-07	7.85285e-07	1	0	T	46999984	T	T	46999984	2	4	171	1	0	0	0	0	0	0	0	1	6769	1335	47	4		4	GPRIN2	10	46999984	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	41752264	46999984	88534763	90	32238											
ZNF511	118472	broad.mit.edu	37	chr10	135123687	135123687	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtatcagtgcttggtagaagGctgcacagagaagttcaaga	13	9	13	6	0	2	3	2	0	0	3	2	4	2	3	0	2	2	6	0	2	5	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr10:135123687G>A	uc001lml.1	+	4	474	c.449G>A	c.(448-450)GGC>GAC	p.G150D	TUBGCP2_uc001lmg.1_5'Flank|TUBGCP2_uc010qvc.1_5'Flank|TUBGCP2_uc009ybk.1_5'Flank|TUBGCP2_uc010qvd.1_5'Flank|TUBGCP2_uc001lmh.1_Intron|ZNF511_uc001lmj.1_Missense_Mutation_p.G150D|ZNF511_uc001lmk.1_Missense_Mutation_p.G150D|ZNF511_uc001lmm.1_RNA			Q8NB15	ZN511_HUMAN	SubName: Full=cDNA FLJ78327; SubName: Full=Zinc finger protein 511, isoform CRA_d;	150	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		all cancers(32;7.56e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.15e-06)|Epithelial(32;9.99e-06)		TTGGTAGAAGGCTGCACAGAG	0.582													52	72					0	0	0	0	A	135123687	A	A	135123687	3	1	171	1	0	0	0	0	1	0	0	0	18022	1203	42	4	463	4	ZNF511	10	135123687	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	88123703	135123687	411060	91	32239											
MRPL23	6150	broad.mit.edu	37	chr11	1973401	1973401	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttacctcgagggcatctataAcgtgcccgtggctgctgtgc	6	11	12	12	3	1	0	0	0	1	0	2	1	1	0	2	2	5	3	2	2	3	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr11:1973401A>G	uc001lux.2	+	3	276	c.185A>G	c.(184-186)AAC>AGC	p.N62S		NM_021134	NP_066957	Q16540	RM23_HUMAN	mitochondrial ribosomal protein L23	62					translation	mitochondrial large ribosomal subunit	nucleotide binding|RNA binding|structural constituent of ribosome			large_intestine(2)|ovary(1)	3		all_epithelial(84;6.24e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.0026)|Lung(200;0.0171)|LUSC - Lung squamous cell carcinoma(625;0.0842)		GGCATCTATAACGTGCCCGTG	0.552													25	20					0	0	0	0	G	1973401	G	G	1973401	3	3	171	1	0	0	0	0	1	0	0	0	9842	43	2	5	195	5	MRPL23	11	1973401	Missense_Mutation	SNP	A	TCGA-CV-5434-01A-01D-1683-08		1973401	133033115	92	32240											
VPS37C	55048	broad.mit.edu	37	chr11	60901634	60901634	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttccgctctgccaggctccGgttggtggccagtgccatct	3	11	13	14	2	2	0	0	0	2	0	4	0	4	0	5	4	2	4	5	4	0	2	rs144006897		TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr11:60901634G>A	uc001nqv.1	-	3	199	c.139C>T	c.(139-141)CGG>TGG	p.R47W	VPS37C_uc001nqw.1_Missense_Mutation_p.R47W	NM_017966	NP_060436	A5D8V6	VP37C_HUMAN	vacuolar protein sorting 37C	47					cellular membrane organization|endosome transport|protein transport	late endosome membrane					0						GCCAGGCTCCGGTTGGTGGCC	0.582													22	62					0	0	0	0	A	60901634	A	A	60901634	3	1	171	1	0	0	0	0	1	0	0	0	17275	1115	39	1	940	1	VPS37C	11	60901634	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	58928233	60901634	74104882	93	32241											
KLC2	64837	broad.mit.edu	37	chr11	66031616	66031616	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggaggtggaatattactatCggcgggcactggagatctat	11	10	14	6	2	1	1	0	0	1	1	2	4	1	3	0	6	1	1	0	6	5	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr11:66031616C>T	uc010rov.1	+	8	1285	c.1042C>T	c.(1042-1044)CGG>TGG	p.R348W	KLC2_uc010row.1_Missense_Mutation_p.R348W|KLC2_uc009yra.2_Intron|KLC2_uc001ohb.2_Missense_Mutation_p.R348W|KLC2_uc010rox.1_Missense_Mutation_p.R271W|KLC2_uc001ohc.2_Missense_Mutation_p.R348W|KLC2_uc001ohd.2_Missense_Mutation_p.R271W|KLC2_uc001ohe.1_Missense_Mutation_p.R209W	NM_001134775	NP_001128247	Q9H0B6	KLC2_HUMAN	kinesin light chain 2 isoform 1	348	TPR 4.				blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0						ATATTACTATCGGCGGGCACT	0.577													3	1					0	0	0	0	T	66031616	T	T	66031616	3	4	171	1	0	0	0	0	1	0	0	0	8373	875	31	1	1068	1	KLC2	11	66031616	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	5129982	66031616	68974900	94	32242											
GPR152	390212	broad.mit.edu	37	chr11	67219165	67219165	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgactgggcctctgccatcGgctctggcagagttggaccc	5	9	14	13	1	2	2	0	1	2	1	3	3	2	3	3	4	1	3	3	4	0	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr11:67219165G>A	uc001olm.2	-	1	1036	c.1031C>T	c.(1030-1032)CCG>CTG	p.P344L	uc009yrw.1_5'Flank|CABP4_uc001oln.2_5'Flank	NM_206997	NP_996880	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	344	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CTCTGCCATCGGCTCTGGCAG	0.637													12	31					0	0	0	0	A	67219165	A	A	67219165	3	1	171	1	0	0	0	0	1	0	0	0	6696	1116	39	1	385	1	GPR152	11	67219165	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	1187549	67219165	67787351	95	32243											
ARAP1	116985	broad.mit.edu	37	chr11	72425238	72425238	+	Frame_Shift_Del	DEL	G	-	-																															ccggctttggaggtatctccGgggggcagggaggtggagag																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr11:72425238delG	uc001osu.2	-	4	827	c.638delC	c.(637-639)CCGfs	p.P213fs	ARAP1_uc001osv.2_Frame_Shift_Del_p.P213fs|ARAP1_uc001osr.2_5'Flank|ARAP1_uc001oss.2_5'UTR|ARAP1_uc009yth.2_5'UTR|ARAP1_uc010rre.1_5'UTR	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	213					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						AGGTATCTCCGGGGGGCAGGG	0.652													---	---	---								-	72425238	-	-	72425238	7	5	171	1	0	1	0	1	0	0	0	0	838	1116	39	0	3842	0	ARAP1	11	72425238	Frame_Shift_Del	DEL	G	TCGA-CV-5434-01A-01D-1683-08	5206073	72425238	62581278	96	32244											
FAM181B	220382	broad.mit.edu	37	chr11	82444616	82444616	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtcccctccttcggctccCgacagcagcgcacccgccgg	5	5	10	21	6	0	0	0	0	0	0	4	1	3	0	6	2	2	3	6	2	0	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr11:82444616C>A	uc001ozp.2	-	1	291	c.156G>T	c.(154-156)TCG>TCT	p.S52S		NM_175885	NP_787081	A6NEQ2	F181B_HUMAN	hypothetical protein LOC220382	52										large_intestine(1)	1						CTTCGGCTCCCGACAGCAGCG	0.692													8	11					7.48243e-07	7.85285e-07	1	0	A	82444616	A	A	82444616	2	1	171	1	0	0	0	0	0	0	0	1	5537	639	23	3		3	FAM181B	11	82444616	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08	10019378	82444616	52561900	97	32245											
MMP12	4321	broad.mit.edu	37	chr11	102734976	102734976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccatcatctgtctcctttCatcatacctgagcaaagaag	11	12	6	12	0	5	2	3	1	2	1	7	2	6	2	3	0	2	1	3	0	3	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr11:102734976C>T	uc001phk.2	-	10	1258	c.1213G>A	c.(1213-1215)GAA>AAA	p.E405K		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	405	Hemopexin-like 3.				positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGTCTCCTTTCATCATACCTG	0.448													5	21					0	0	0	0	T	102734976	T	T	102734976	3	4	171	1	0	0	0	0	1	0	0	0	9704	835	29	2	207	2	MMP12	11	102734976	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	20290360	102734976	32271540	98	32246											
CACNA2D4	93589	broad.mit.edu	37	chr12	1963138	1963138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggacatgttgagggccagcGctgtccagtaggcttccatg	7	9	14	11	2	0	1	0	1	0	0	2	2	2	2	3	3	1	4	3	3	1	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:1963138G>A	uc001qjp.2	-	23	2456	c.2225C>T	c.(2224-2226)GCG>GTG	p.A742V	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.A606V|CACNA2D4_uc009zdr.1_RNA	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	742	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GAGGGCCAGCGCTGTCCAGTA	0.617													4	15					0	0	0	0	A	1963138	A	A	1963138	3	1	171	1	0	0	0	0	1	0	0	0	2563	1087	38	1	1252	1	CACNA2D4	12	1963138	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08		1963138	131888757	99	32247											
ANO2	57101	broad.mit.edu	37	chr12	6055399	6055399	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttatagagaaggagcctggGgaagcaaaggggagtaagtg	14	7	17	3	0	0	1	0	0	0	1	0	5	0	4	1	5	2	2	1	5	6	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:6055399G>A	uc001qnm.2	-	1	1	c.-71_splice	c.e1-1			NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2							chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						AGGAGCCTGGGGAAGCAAAGG	0.473													3	45					0	0	0	0	A	6055399	A	A	6055399	5	1	171	1	0	0	0	0	0	0	1	0	697	1247	43	4		4	ANO2	12	6055399	Splice_Site	SNP	G	TCGA-CV-5434-01A-01D-1683-08	4092261	6055399	127796496	100	32248											
ACSM4	341392	broad.mit.edu	37	chr12	7469736	7469736	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggtccatattttgcagattCgcctctgaagagcacagctg	9	11	11	10	1	1	3	0	1	1	2	3	3	2	3	2	1	3	3	2	1	2	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:7469736C>T	uc001qsx.1	+	4	624	c.624C>T	c.(622-624)TTC>TTT	p.F208F		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	208					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						TTTGCAGATTCGCCTCTGAAG	0.483													10	23					0	0	0	0	T	7469736	T	T	7469736	2	4	171	1	0	0	0	0	0	0	0	1	186	883	31	1		1	ACSM4	12	7469736	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08	1414337	7469736	126382159	101	32249											
ATF7IP	55729	broad.mit.edu	37	chr12	14591118	14591118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgctgcagtgtgctgtatttGataagactttggcagaattg	9	14	12	6	1	0	3	0	1	0	2	0	3	0	3	0	1	2	5	0	1	3	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:14591118G>A	uc001rbw.2	+	5	2004	c.1846G>A	c.(1846-1848)GAT>AAT	p.D616N	ATF7IP_uc010shs.1_Missense_Mutation_p.D615N|ATF7IP_uc001rbu.2_Missense_Mutation_p.D616N|ATF7IP_uc001rbv.1_Missense_Mutation_p.D615N|ATF7IP_uc001rbx.2_Missense_Mutation_p.D615N|ATF7IP_uc010sht.1_Missense_Mutation_p.D616N|ATF7IP_uc001rby.3_Missense_Mutation_p.D616N|ATF7IP_uc001rca.2_Missense_Mutation_p.D616N	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	616	Interaction with SETDB1.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						TGCTGTATTTGATAAGACTTT	0.383													10	36					0	0	0	0	A	14591118	A	A	14591118	3	1	171	1	0	0	0	0	1	0	0	0	1089	1290	45	2	1860	2	ATF7IP	12	14591118	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	7121382	14591118	119260777	102	32250											
PTPRO	5800	broad.mit.edu	37	chr12	15669884	15669884	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaactgtttccttaactgcAtccgtggtaatcttccctta	8	15	6	12	1	1	0	0	0	1	0	4	0	4	0	3	1	3	4	3	1	4	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:15669884A>T	uc001rcv.1	+	9	1947	c.1773A>T	c.(1771-1773)GCA>GCT	p.A591A	PTPRO_uc001rcw.1_Silent_p.A591A|PTPRO_uc001rcu.1_Silent_p.A591A	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	591	Fibronectin type-III 6.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				CCTTAACTGCATCCGTGGTAA	0.373													59	82					0	0	0	0	T	15669884	T	T	15669884	2	4	171	1	0	0	0	0	0	0	0	1	12874	204	8	5		5	PTPRO	12	15669884	Silent	SNP	A	TCGA-CV-5434-01A-01D-1683-08	1078766	15669884	118182011	103	32251											
PLCZ1	89869	broad.mit.edu	37	chr12	18872484	18872484	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atatcttgataaacttttctAcattcatttttaaacagtag	14	18	3	6	0	3	1	1	1	2	0	3	1	3	1	0	0	3	1	0	0	7	11			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:18872484A>G	uc010sid.1	-	5	641	c.450T>C	c.(448-450)TGT>TGC	p.C150C	PLCZ1_uc001rdv.3_Silent_p.C46C|PLCZ1_uc001rdw.3_Intron|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	150					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AAACTTTTCTACATTCATTTT	0.279													3	17					0	0	0	0	G	18872484	G	G	18872484	2	3	171	1	0	0	0	0	0	0	0	1	12099	389	14	5		5	PLCZ1	12	18872484	Silent	SNP	A	TCGA-CV-5434-01A-01D-1683-08	3202600	18872484	114979411	104	32252											
ABCC9	10060	broad.mit.edu	37	chr12	22061049	22061054	+	In_Frame_Del	DEL	TAAAGT	-	-																															ctctgccaactttgtagcaaTaaagtactgaattggcgcaa																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:22061049_22061054delTAAAGT	uc001rfi.1	-	9	1432_1437	c.1412_1417delACTTTA	c.(1411-1419)TACTTTATT>TTT	p.471_473YFI>F	ABCC9_uc001rfh.2_In_Frame_Del_p.471_473YFI>F|ABCC9_uc001rfj.1_In_Frame_Del_p.471_473YFI>F	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	471_473	ABC transmembrane type-1 1.|Helical; Name=9; (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTTGTAGCAATAAAGTACTGAATTGG	0.364													---	---	---								-	22061054	-	-	22061049	7	5	171	1	0	1	0	1	0	0	0	0	59	1406	49	0	3494	0	ABCC9	12	22061049	In_Frame_Del	DEL	TAAAGT	TCGA-CV-5434-01A-01D-1683-08	3188565	22061049	111790846	105	32253											
ST8SIA1	6489	broad.mit.edu	37	chr12	22487097	22487097	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	catgggcagccgggtccgcgGgaacttccacgccagtacag	8	5	14	14	4	0	0	0	0	0	0	2	1	2	1	4	3	3	2	4	3	2	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:22487097G>A	uc001rfo.3	-	1	552	c.70C>T	c.(70-72)CCG>TCG	p.P24S	ST8SIA1_uc009zix.2_5'UTR|uc001rfp.1_Intron	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	24	Cytoplasmic (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						CGGGTCCGCGGGAACTTCCAC	0.692													67	85					0	0	0	0	A	22487097	A	A	22487097	3	1	171	1	0	0	0	0	1	0	0	0	15297	1232	43	4	1020	4	ST8SIA1	12	22487097	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	426048	22487097	111364798	106	32254											
MLL2	8085	broad.mit.edu	37	chr12	49447085	49447086	+	Frame_Shift_Ins	INS	-	AC	AC																															gtctcacaaaccaacatcttINSagagtcattcccaggtttcc																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:49447085_49447086insAC	uc001rta.3	-	7	858_859	c.858_859insGT	c.(856-861)TCTAAGfs	p.S286fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	286_287	PHD-type 2.|RING-type 2; degenerate.|Cys-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ACCAACATCTTAGAGTCATTCC	0.455			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								AC	49447086	AC	AC	49447085	7	5	171	1	0	1	1	0	0	0	0	0	9674	1763	61	0	15946	0	MLL2	12	49447085	Frame_Shift_Ins	INS	-	TCGA-CV-5434-01A-01D-1683-08	26959988	49447085	84404810	107	32255											
PTPRB	5787	broad.mit.edu	37	chr12	70925945	70925945	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggttccagtcctacccacaCcagcactagaagagatggca	13	6	9	13	0	0	2	0	0	0	2	2	3	2	2	4	2	2	3	4	2	3	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:70925945C>A	uc001swb.3	-	30	5750	c.5720G>T	c.(5719-5721)GGT>GTT	p.G1907V	uc001svz.2_Intron|PTPRB_uc010sto.1_Missense_Mutation_p.G1817V|PTPRB_uc010stp.1_Missense_Mutation_p.G1817V|PTPRB_uc001swc.3_Missense_Mutation_p.G2125V|PTPRB_uc001swa.3_Missense_Mutation_p.G2037V	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1907	Cytoplasmic (Potential).|Substrate binding (By similarity).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CCTACCCACACCAGCACTAGA	0.433													11	28					5.50884e-06	5.72487e-06	1	0	A	70925945	A	A	70925945	3	1	171	1	0	0	0	0	1	0	0	0	12861	507	18	4	285	4	PTPRB	12	70925945	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	21478860	70925945	62925950	108	32256											
PTPRR	5801	broad.mit.edu	37	chr12	71078046	71078046	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctccttgccactgtagcccTagatggagtaaagaaacaaa	14	9	8	10	0	1	2	0	0	1	2	2	3	1	3	3	1	3	2	3	1	6	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:71078046T>A	uc001swi.1	-	10	1776	c.1360_splice	c.e10-1	p.G454_splice	PTPRR_uc001swh.1_Splice_Site_p.G209_splice|PTPRR_uc009zrs.2_Splice_Site_p.G303_splice|PTPRR_uc010stq.1_Splice_Site_p.G342_splice|PTPRR_uc010str.1_Splice_Site_p.G303_splice	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R						in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		ACTGTAGCCCTAGATGGAGTA	0.453													14	27					0	0	0	0	A	71078046	A	A	71078046	5	1	171	1	0	0	0	0	0	0	1	0	12875	1536	53	5	635	5	PTPRR	12	71078046	Splice_Site	SNP	T	TCGA-CV-5434-01A-01D-1683-08	152101	71078046	62773849	109	32257											
HCFC2	29915	broad.mit.edu	37	chr12	104492210	104492210	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttaaaaataatacagctttGgtgagccagttttatttgct	12	17	7	5	0	0	1	0	1	0	0	0	1	0	1	1	1	4	3	1	1	6	8			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:104492210G>T	uc001tkj.3	+	13	1933	c.1830G>T	c.(1828-1830)TTG>TTT	p.L610F	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	610	Fibronectin type-III 2.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						ATACAGCTTTGGTGAGCCAGT	0.378													30	42					3.73988e-18	4.21731e-18	1	0	T	104492210	T	T	104492210	3	4	171	1	0	0	0	0	1	0	0	0	7032	1339	47	4	1880	4	HCFC2	12	104492210	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	33414164	104492210	29359685	110	32258											
KIAA1033	23325	broad.mit.edu	37	chr12	105536970	105536970	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaggcatttagagtcctaTgagatacttctggattgcta	11	13	10	7	0	1	2	0	1	1	2	2	4	2	3	1	2	2	3	1	2	5	7			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:105536970T>C	uc001tld.2	+	20	2046	c.1959T>C	c.(1957-1959)TAT>TAC	p.Y653Y	KIAA1033_uc010swr.1_Silent_p.Y654Y|KIAA1033_uc010sws.1_Silent_p.Y465Y	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	653					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						TAGAGTCCTATGAGATACTTC	0.333													3	32					0	0	0	0	C	105536970	C	C	105536970	2	2	171	1	0	0	0	0	0	0	0	1	8245	1471	51	5		5	KIAA1033	12	105536970	Silent	SNP	T	TCGA-CV-5434-01A-01D-1683-08	1044760	105536970	28314925	111	32259											
NUAK1	9891	broad.mit.edu	37	chr12	106461007	106461007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcaagatgcccttcctcCggcaggagaggctgtgggag	7	9	15	10	1	1	2	1	0	0	2	3	4	3	3	3	4	1	3	3	4	1	2	rs117517173	byFrequency	TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:106461007C>T	uc001tlj.1	-	7	2939	c.1559G>A	c.(1558-1560)CGG>CAG	p.R520Q		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	520							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						GCCCTTCCTCCGGCAGGAGAG	0.607													4	96					0	0	0	0	T	106461007	T	T	106461007	3	4	171	1	0	0	0	0	1	0	0	0	10766	652	23	1	430	1	NUAK1	12	106461007	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	924037	106461007	27390888	112	32260											
DDX54	79039	broad.mit.edu	37	chr12	113599728	113599728	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtaggagctgctgatgtagCggccgctctctgtcttaatc	6	13	12	10	2	2	1	0	1	2	0	4	2	2	2	1	2	3	5	1	2	3	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:113599728C>G	uc001tup.2	-	18	2298	c.2270G>C	c.(2269-2271)CGC>CCC	p.R757P	DDX54_uc001tuq.3_Missense_Mutation_p.R757P	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	757					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						GCTGATGTAGCGGCCGCTCTC	0.582													48	92					0	0	0	0	G	113599728	G	G	113599728	3	3	171	1	0	0	0	0	1	0	0	0	4389	768	27	3	390	3	DDX54	12	113599728	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	7138721	113599728	20252167	113	32261											
CAMKK2	10645	broad.mit.edu	37	chr12	121735513	121735513	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaagggaatcgagttgacagGagagtcaacctccaagttaa	16	7	11	7	1	1	2	1	1	0	1	3	5	2	3	2	2	1	2	2	2	5	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:121735513G>A	uc001tzu.2	-						CAMKK2_uc001tzt.2_5'Flank|CAMKK2_uc001tzv.2_5'UTR|CAMKK2_uc001tzw.2_5'UTR|CAMKK2_uc001tzx.2_5'UTR|CAMKK2_uc001tzy.2_5'UTR|CAMKK2_uc001uab.2_5'UTR|CAMKK2_uc001uac.2_5'UTR|CAMKK2_uc001uad.1_5'Flank	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase						calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GAGTTGACAGGAGAGTCAACC	0.527													8	9					0	0	0	0	A	121735513	A	A	121735513	1	1	171	0	1	0	0	0	0	0	0	0	2619	1189	41	2		2	CAMKK2	12	121735513	5'Flank	SNP	G	TCGA-CV-5434-01A-01D-1683-08	8135785	121735513	12116382	114	32262											
RIMBP2	23504	broad.mit.edu	37	chr12	130898786	130898786	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatccgggccgggagctcttCggcaccagggtcagtttctg	5	9	15	12	3	3	0	1	0	2	0	5	2	4	1	3	4	1	3	3	4	0	2	rs138034003		TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr12:130898786C>T	uc001uil.2	-	14	2700	c.2536G>A	c.(2536-2538)GAA>AAA	p.E846K		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	846						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGGAGCTCTTCGGCACCAGGG	0.567													29	57					0	0	0	0	T	130898786	T	T	130898786	3	4	171	1	0	0	0	0	1	0	0	0	13428	893	31	1	646	1	RIMBP2	12	130898786	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	9163273	130898786	2953109	115	32263											
FLT1	2321	broad.mit.edu	37	chr13	28896990	28896990	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccggagctcgcaaagctttCgctgctggtgacgctatcta	7	10	12	12	4	1	1	0	1	1	0	3	2	1	2	1	2	3	6	1	2	3	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr13:28896990C>T	uc001usb.3	-	21	3175	c.2890G>A	c.(2890-2892)GAA>AAA	p.E964K	FLT1_uc010aap.2_5'Flank|FLT1_uc010aaq.2_Missense_Mutation_p.E89K|FLT1_uc001usa.3_Missense_Mutation_p.E182K	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	964	Cytoplasmic (Potential).|Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GCAAAGCTTTCGCTGCTGGTG	0.478													4	109					0	0	0	0	T	28896990	T	T	28896990	3	4	171	1	0	0	0	0	1	0	0	0	5973	893	31	1	1166	1	FLT1	13	28896990	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08		28896990	86272888	116	32264											
FREM2	341640	broad.mit.edu	37	chr13	39266020	39266021	+	Nonsense_Mutation	DNP	TG	CT	CT																															tttgagtttcaagtcaccgaTggacgtaaccctgtctttcg																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr13:39266020_39266021TG>CT	uc001uwv.2	+	1	4848_4849	c.4539_4540TG>CT	c.(4537-4542)GATGGA>GACTGA	p.G1514*		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1514	Extracellular (Potential).|CSPG 10.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AAGTCACCGATGGACGTAACCC	0.45													18	57					0	0	0	0	CT	39266021	CT	CT	39266020	4	2	171	1	0	0	0	0	0	1	0	0	6079	1461	51	5	4541	5	FREM2	13	39266020	Nonsense_Mutation	DNP	TG	TCGA-CV-5434-01A-01D-1683-08	10369030	39266020	75903858	117	32265											
DPF3	8110	broad.mit.edu	37	chr14	73198527	73198527	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gggaatacctgtatttcctgGatgctttcctcctccctggc	5	14	9	13	0	0	0	0	0	0	0	4	2	4	2	5	3	2	2	5	3	3	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr14:73198527G>C	uc001xnc.2	-	4	430	c.417C>G	c.(415-417)ATC>ATG	p.I139M	DPF3_uc001xnf.2_RNA|DPF3_uc010ari.1_Missense_Mutation_p.I139M|DPF3_uc010ttq.1_Missense_Mutation_p.I149M	NM_012074	NP_036206	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	139					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GTATTTCCTGGATGCTTTCCT	0.577													5	16					0	0	0	0	C	73198527	C	C	73198527	3	2	171	1	0	0	0	0	1	0	0	0	4740	1164	41	2	680	2	DPF3	14	73198527	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08		73198527	34151013	118	32266											
NUMB	8650	broad.mit.edu	37	chr14	73749071	73749071	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtcagagggcaccaaccttgGaaggtaggagattgtggtgc	10	8	16	7	0	1	2	1	0	0	2	1	4	1	3	2	5	2	2	2	5	3	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr14:73749071G>T	uc001xny.1	-	11	1412	c.1092C>A	c.(1090-1092)TTC>TTA	p.F364L	NUMB_uc010aro.1_Intron|NUMB_uc010arp.1_Intron|NUMB_uc010arq.1_Missense_Mutation_p.F266L|NUMB_uc010arr.1_Missense_Mutation_p.F255L|NUMB_uc001xoa.1_Missense_Mutation_p.F364L|NUMB_uc001xnz.1_Missense_Mutation_p.F353L|NUMB_uc001xob.1_Missense_Mutation_p.F353L|NUMB_uc001xod.1_Missense_Mutation_p.F364L|NUMB_uc001xoc.1_Missense_Mutation_p.F364L|NUMB_uc010ars.1_Missense_Mutation_p.F353L|NUMB_uc010ttz.1_Missense_Mutation_p.F110L	NM_001005743	NP_001005743	P49757	NUMB_HUMAN	numb homolog isoform 1	364					axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				ovary(2)|central_nervous_system(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		accaaccttggaaggtaggag	0.323													7	30					5.18039e-06	5.41006e-06	1	0	T	73749071	T	T	73749071	3	4	171	1	0	0	0	0	1	0	0	0	10805	1165	41	2	875	2	NUMB	14	73749071	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	550544	73749071	33600469	119	32267											
ATP8B4	79895	broad.mit.edu	37	chr15	50273431	50273431	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagagtattcatcaatctaTcaatgcttgtccttttaaac	12	16	4	9	0	4	1	3	0	1	1	5	1	5	1	1	0	2	2	1	0	7	7			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr15:50273431T>G	uc001zxu.2	-	11	951	c.809A>C	c.(808-810)GAT>GCT	p.D270A	ATP8B4_uc010ber.2_Missense_Mutation_p.D143A|ATP8B4_uc010ufd.1_Missense_Mutation_p.D143A|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	270	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CATCAATCTATCAATGCTTGT	0.308													6	33					0	0	0	0	G	50273431	G	G	50273431	3	3	171	1	0	0	0	0	1	0	0	0	1199	1435	50	5	2841	5	ATP8B4	15	50273431	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08		50273431	52257961	120	32268											
ALDH1A2	8854	broad.mit.edu	37	chr15	58357778	58357778	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgggcgacggcaggaggTgcagcgacgccatgagggcg	7	3	21	10	6	0	1	0	1	0	0	0	4	0	2	1	5	2	2	1	5	0	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr15:58357778T>C	uc002aex.2	-	1	129	c.71A>G	c.(70-72)CAC>CGC	p.H24R	ALDH1A2_uc002aey.2_Missense_Mutation_p.H24R|ALDH1A2_uc010ugv.1_5'UTR|ALDH1A2_uc010ugw.1_Intron	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	24					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CGGCAGGAGGTGCAGCGACGC	0.652													9	35					0	0	0	0	C	58357778	C	C	58357778	3	2	171	1	0	0	0	0	1	0	0	0	491	1696	59	5	1537	5	ALDH1A2	15	58357778	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	8084347	58357778	44173614	121	32269											
ISLR2	57611	broad.mit.edu	37	chr15	74425155	74425155	+	Frame_Shift_Del	DEL	C	-	-																															ctaggagtggccggatcatgCccggagccgtgcgcctgcgt																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr15:74425155delC	uc002axd.2	+	4	829	c.60delC	c.(58-60)TGCfs	p.C20fs	ISLR2_uc002axe.2_Frame_Shift_Del_p.C20fs|ISLR2_uc010bjg.2_Frame_Shift_Del_p.C20fs|ISLR2_uc010bjf.2_Frame_Shift_Del_p.C20fs	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	20	Extracellular (Potential).|LRRNT.				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						CCGGATCATGCCCGGAGCCGT	0.617													---	---	---								-	74425155	-	-	74425155	7	5	171	1	0	1	0	1	0	0	0	0	7898	747	26	0	62	0	ISLR2	15	74425155	Frame_Shift_Del	DEL	C	TCGA-CV-5434-01A-01D-1683-08	16067377	74425155	28106237	122	32270											
MFGE8	4240	broad.mit.edu	37	chr15	89449094	89449094	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaggggtctcaaacaggttGacatgcaccgcgtttttgtt	9	12	11	9	2	1	1	1	1	1	0	2	1	1	1	1	3	2	4	1	3	1	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr15:89449094G>A	uc002bng.3	-	5	692	c.579C>T	c.(577-579)GTC>GTT	p.V193V	MFGE8_uc002bnf.3_Silent_p.V81V|MFGE8_uc002bnh.3_Silent_p.V193V|MFGE8_uc010bnn.2_Silent_p.V185V|MFGE8_uc010upq.1_Silent_p.V149V|MFGE8_uc010upr.1_Silent_p.V193V	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	193	F5/8 type C 1.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					CAAACAGGTTGACATGCACCG	0.582													22	62					0	0	0	0	A	89449094	A	A	89449094	2	1	171	1	0	0	0	0	0	0	0	1	9573	1277	45	2		2	MFGE8	15	89449094	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	15023939	89449094	13082298	123	32271											
TEKT5	146279	broad.mit.edu	37	chr16	10788293	10788293	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttccagaagccaatgtcCgacagcctctggcccaggtt	9	8	10	14	1	1	1	0	0	1	1	3	3	3	1	5	2	2	1	5	2	2	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr16:10788293C>G	uc002czz.1	-	1	510	c.438G>C	c.(436-438)TCG>TCC	p.S146S		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	146	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						AGCCAATGTCCGACAGCCTCT	0.612													31	119					0	0	0	0	G	10788293	G	G	10788293	2	3	171	1	0	0	0	0	0	0	0	1	15822	639	23	3		3	TEKT5	16	10788293	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08		10788293	79566460	124	32272											
ABCC11	85320	broad.mit.edu	37	chr16	48250115	48250115	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaatgctgcagatgaccagCgatgcgcaggtgatcagtac	12	7	13	9	2	1	3	1	2	0	1	1	5	1	3	1	1	5	4	1	1	2	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr16:48250115C>T	uc002eff.1	-	6	1211	c.861G>A	c.(859-861)TCG>TCA	p.S287S	ABCC11_uc002efg.1_Silent_p.S287S|ABCC11_uc002efh.1_Silent_p.S287S|ABCC11_uc010vgk.1_5'Flank|ABCC11_uc010vgl.1_Silent_p.S287S	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	287	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				AGATGACCAGCGATGCGCAGG	0.468									Cerumen_Type				27	114					0	0	0	0	T	48250115	T	T	48250115	2	4	171	1	0	0	0	0	0	0	0	1	51	755	27	1		1	ABCC11	16	48250115	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08	37461822	48250115	42104638	125	32273											
SNX20	124460	broad.mit.edu	37	chr16	50709754	50709754	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagtttgacgtgcttccagCggcatttctggttctgccag	5	13	12	11	2	2	1	0	1	2	0	3	1	3	1	2	2	3	5	2	2	0	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr16:50709754C>A	uc002egk.2	-	3	382	c.209G>T	c.(208-210)CGC>CTC	p.R70L	SNX20_uc010vgp.1_Missense_Mutation_p.R70L|SNX20_uc002egi.3_Missense_Mutation_p.R70L	NM_182854	NP_878274	Q7Z614	SNX20_HUMAN	sorting nexin 20 isoform 1	70					cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			ovary(1)	1						GTGCTTCCAGCGGCATTTCTG	0.522													12	57					0.000978159	0.00099697	1	0	A	50709754	A	A	50709754	3	1	171	1	0	0	0	0	1	0	0	0	14956	768	27	3	892	3	SNX20	16	50709754	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	2459639	50709754	39644999	126	32274											
ZNF276	92822	broad.mit.edu	37	chr16	89789220	89789220	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtcaacgcctccccggctGgtcgccggaagccttgtgca	5	7	14	15	4	1	0	1	0	0	0	3	1	2	1	5	4	3	2	5	4	2	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr16:89789220G>A	uc002fos.3	+	2	584	c.487G>A	c.(487-489)GGT>AGT	p.G163S	C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Missense_Mutation_p.G88S|ZNF276_uc002foq.3_Missense_Mutation_p.G88S|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCCCCGGCTGGTCGCCGGAA	0.592													7	45					0	0	0	0	A	89789220	A	A	89789220	3	1	171	1	0	0	0	0	1	0	0	0	17878	1348	47	4	493	4	ZNF276	16	89789220	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	39079466	89789220	565533	127	32275											
DHX33	56919	broad.mit.edu	37	chr17	5365857	5365857	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacatcatcaaagcgcactgTatagccaacctgtgcaggga	13	7	10	11	1	2	0	2	0	0	0	2	2	2	1	2	1	4	3	2	1	4	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:5365857T>C	uc002gca.2	-	3	462	c.460A>G	c.(460-462)ACA>GCA	p.T154A	DHX33_uc002gbz.2_5'Flank|DHX33_uc002gcb.2_Translation_Start_Site|DHX33_uc010clf.2_Intron	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	154	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						AAGCGCACTGTATAGCCAACC	0.294													18	60					0	0	0	0	C	5365857	C	C	5365857	3	2	171	1	0	0	0	0	1	0	0	0	4528	1638	57	5	1703	5	DHX33	17	5365857	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08		5365857	75829353	128	32276											
TP53	7157	broad.mit.edu	37	chr17	7577574	7577574	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcaggaactgttacacatgTagttgtagtggatggtggta	10	13	14	4	0	0	0	0	0	0	0	0	2	0	2	0	4	3	6	0	4	5	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:7577574T>C	uc002gim.2	-	7	901	c.707A>G	c.(706-708)TAC>TGC	p.Y236C	TP53_uc002gig.1_Missense_Mutation_p.Y236C|TP53_uc002gih.2_Missense_Mutation_p.Y236C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y104C|TP53_uc010cng.1_Missense_Mutation_p.Y104C|TP53_uc002gii.1_Missense_Mutation_p.Y104C|TP53_uc010cnh.1_Missense_Mutation_p.Y236C|TP53_uc010cni.1_Missense_Mutation_p.Y236C|TP53_uc002gij.2_Missense_Mutation_p.Y236C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y143C|TP53_uc002gio.2_Missense_Mutation_p.Y104C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	236	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> S (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y236C(46)|p.Y236N(12)|p.Y236*(9)|p.Y236H(9)|p.0?(7)|p.Y236D(6)|p.Y236del(4)|p.Y236S(3)|p.Y236Y(2)|p.Y236fs*4(2)|p.Y236_M237delYM(1)|p.I232_Y236delIHYNY(1)|p.Y236fs*5(1)|p.H233fs*6(1)|p.Y236_M237insXX(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.N235_Y236delNY(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTACACATGTAGTTGTAGTG	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			30	29					0	0	0	0	C	7577574	C	C	7577574	3	2	171	1	0	0	0	0	1	0	0	0	16448	1638	57	5	583	5	TP53	17	7577574	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	2211717	7577574	73617636	129	32277											
TP53	7157	broad.mit.edu	37	chr17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcaccaccacactatgtcGaaaagtgtttctgtcatcca	11	10	8	12	1	2	0	1	0	1	0	4	1	3	0	3	1	0	2	3	1	3	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	25					0	0	0	0	A	7578212	A	A	7578212	4	1	171	1	0	0	0	0	0	1	0	0	16448	1066	37	1	657	1	TP53	17	7578212	Nonsense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	638	7578212	73616998	130	32278											
PFAS	5198	broad.mit.edu	37	chr17	8170695	8170695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttattctcccccaaggtggtCccagcccccgagtcgccatc	6	9	8	18	2	1	0	0	0	1	0	5	1	2	0	6	2	1	0	6	2	2	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:8170695C>T	uc002gkr.2	+	25	3322	c.3181C>T	c.(3181-3183)CCC>TCC	p.P1061S	PFAS_uc010vuv.1_Missense_Mutation_p.P637S|PFAS_uc002gks.2_Missense_Mutation_p.P140S	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	1061					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCAAGGTGGTCCCAGCCCCCG	0.607													70	110					0	0	0	0	T	8170695	T	T	8170695	3	4	171	1	0	0	0	0	1	0	0	0	11809	855	30	2	3275	2	PFAS	17	8170695	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	592483	8170695	73024515	131	32279											
ZNF18	7566	broad.mit.edu	37	chr17	11895778	11895778	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acccattgccacagtctctgGgggtcccccttcaagctttc	6	11	8	16	0	2	0	1	0	1	0	5	0	3	0	4	2	2	1	4	2	1	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:11895778G>A	uc002gng.1	-	4	974	c.369C>T	c.(367-369)CCC>CCT	p.P123P	ZNF18_uc002gnh.1_Silent_p.P123P|ZNF18_uc002gni.1_Silent_p.P123P	NM_144680	NP_653281	P17022	ZNF18_HUMAN	zinc finger protein 18	123	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)	1				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		ACAGTCTCTGGGGGTCCCCCT	0.512													25	33					0	0	0	0	A	11895778	A	A	11895778	2	1	171	1	0	0	0	0	0	0	0	1	17814	1219	43	4		4	ZNF18	17	11895778	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	3725083	11895778	69299432	132	32280											
USP22	23326	broad.mit.edu	37	chr17	20924462	20924462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcgctgctcctccttggCgattatttccatgtctttgt	3	20	7	11	2	1	0	0	0	1	0	5	1	4	0	3	1	1	2	3	1	1	6			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:20924462C>T	uc002gym.3	-	3	586	c.382G>A	c.(382-384)GCC>ACC	p.A128T	USP22_uc002gyn.3_Missense_Mutation_p.A116T|USP22_uc002gyl.3_Missense_Mutation_p.A23T	NM_015276	NP_056091	Q9UPT9	UBP22_HUMAN	ubiquitin thiolesterase 22	128					cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1						TCCTCCTTGGCGATTATTTCC	0.483													18	28					0	0	0	0	T	20924462	T	T	20924462	3	4	171	1	0	0	0	0	1	0	0	0	17122	768	27	1	1239	1	USP22	17	20924462	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	9028684	20924462	60270748	133	32281											
MAP2K3	5606	broad.mit.edu	37	chr17	21215472	21215472	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agattgagatggccatcctgCggttcccttacgagtcctgg	7	11	12	11	2	0	2	0	1	0	2	3	4	3	2	4	3	2	1	4	3	1	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:21215472C>T	uc002gys.2	+	10	1058	c.793C>T	c.(793-795)CGG>TGG	p.R265W	MAP2K3_uc002gyt.2_Missense_Mutation_p.R236W|MAP2K3_uc002gyu.2_Missense_Mutation_p.R236W	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	265	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GGCCATCCTGCGGTTCCCTTA	0.677													4	48					0	0	0	0	T	21215472	T	T	21215472	3	4	171	1	0	0	0	0	1	0	0	0	9291	759	27	1	831	1	MAP2K3	17	21215472	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	291010	21215472	59979738	134	32282											
MYO19	80179	broad.mit.edu	37	chr17	34863298	34863298	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atgagatccaaacagggctgGttgtcctggtagttgatgaa	11	11	13	6	0	0	3	0	3	0	1	2	4	2	3	2	3	1	4	2	3	3	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:34863298G>C	uc010wcy.1	-	17	2399	c.1407C>G	c.(1405-1407)AAC>AAG	p.N469K	MYO19_uc002hmw.2_Intron|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	469	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AACAGGGCTGGTTGTCCTGGT	0.542													39	32					0	0	0	0	C	34863298	C	C	34863298	3	2	171	1	0	0	0	0	1	0	0	0	10120	1252	44	4	1549	4	MYO19	17	34863298	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	13647826	34863298	46331912	135	32283											
PNMT	5409	broad.mit.edu	37	chr17	37826489	37826489	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggccaggctgacggtggtGccagtgtctgaggaggaggt	7	7	20	7	1	1	2	0	2	1	0	1	5	1	4	2	7	1	1	2	7	0	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:37826489G>A	uc002hsi.1	+	3	918	c.696G>A	c.(694-696)GTG>GTA	p.V232V		NM_002686	NP_002677	P11086	PNMT_HUMAN	phenylethanolamine N-methyltransferase	232					catecholamine biosynthetic process|hormone biosynthetic process	cytosol	phenylethanolamine N-methyltransferase activity			ovary(1)	1	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TGACGGTGGTGCCAGTGTCTG	0.662													9	4					0	0	0	0	A	37826489	A	A	37826489	2	1	171	1	0	0	0	0	0	0	0	1	12214	1306	46	4		4	PNMT	17	37826489	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	2963191	37826489	43368721	136	32284											
ERBB2	2064	broad.mit.edu	37	chr17	37865676	37865676	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacaaccagctggctctcaCactgatagacaccaaccgct	13	6	7	15	1	1	2	1	1	1	1	2	3	1	2	3	1	4	3	3	1	4	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:37865676C>T	uc002hso.2	+	4	783	c.545C>T	c.(544-546)ACA>ATA	p.T182I	ERBB2_uc002hsm.2_Missense_Mutation_p.T152I|ERBB2_uc010cwa.2_Missense_Mutation_p.T167I|ERBB2_uc002hsp.2_5'UTR|ERBB2_uc010cwb.2_Missense_Mutation_p.T182I|ERBB2_uc010wek.1_Intron|ERBB2_uc002hsl.2_Missense_Mutation_p.T152I|ERBB2_uc002hsn.1_Missense_Mutation_p.T182I	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	182	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CTGGCTCTCACACTGATAGAC	0.562		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			14	36					0	0	0	0	T	37865676	T	T	37865676	3	4	171	1	0	0	0	0	1	0	0	0	5230	478	17	4	559	4	ERBB2	17	37865676	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	39187	37865676	43329534	137	32285											
TMUB2	79089	broad.mit.edu	37	chr17	42266692	42266692	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgagaaggctgaagaggCgggtgaaggtcggggagact	11	6	20	4	2	0	6	0	4	0	3	1	8	0	6	0	6	0	1	0	6	3	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:42266692C>T	uc002ifo.2	+	3	495	c.338C>T	c.(337-339)GCG>GTG	p.A113V	C17orf65_uc002ifn.2_5'Flank|TMUB2_uc002ifp.2_Missense_Mutation_p.A93V|TMUB2_uc010wiu.1_Intron|TMUB2_uc002ifq.2_Missense_Mutation_p.A113V|TMUB2_uc002ifr.2_Intron|TMUB2_uc002ifs.2_Intron|TMUB2_uc002ift.2_Missense_Mutation_p.A93V|TMUB2_uc002ifu.2_Intron|TMUB2_uc002ifv.2_Missense_Mutation_p.A93V|TMUB2_uc002ifw.1_Missense_Mutation_p.A93V|TMUB2_uc002ifx.2_Intron|TMUB2_uc002ify.2_Intron	NM_001076674	NP_001070142	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain	113						integral to membrane				lung(1)	1		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GCTGAAGAGGCGGGTGAAGGT	0.612													3	54					0	0	0	0	T	42266692	T	T	42266692	3	4	171	1	0	0	0	0	1	0	0	0	16331	768	27	1	344	1	TMUB2	17	42266692	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	4401016	42266692	38928518	138	32286											
EFTUD2	9343	broad.mit.edu	37	chr17	42940103	42940103	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccacagagatccaaaggcGgcccacggtgcatatctggg	10	5	14	12	2	1	1	0	0	1	1	2	2	2	1	3	5	1	1	3	5	2	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:42940103G>A	uc002ihn.2	-	16	1846	c.1585C>T	c.(1585-1587)CGC>TGC	p.R529C	EFTUD2_uc010wje.1_Missense_Mutation_p.R494C|EFTUD2_uc010wjf.1_Missense_Mutation_p.R519C	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	529						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				ATCCAAAGGCGGCCCACGGTG	0.597													3	24					0	0	0	0	A	42940103	A	A	42940103	3	1	171	1	0	0	0	0	1	0	0	0	4983	1116	39	1	1385	1	EFTUD2	17	42940103	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	673411	42940103	38255107	139	32287											
C17orf57	124989	broad.mit.edu	37	chr17	45419342	45419343	+	Frame_Shift_Ins	INS	-	A	A																															gtcctctgatttttcaggagINSaaaaaaaagttgggagaaag																										TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	2db53391-19dc-48e2-9636-d744b534591e	g.chr17:45419342_45419343insA	uc002iln.2	+	6	658_659	c.247_248insA	c.(247-249)GAAfs	p.E83fs	ITGB3_uc010wkr.1_RNA|C17orf57_uc002ilm.2_Frame_Shift_Ins_p.E83fs|C17orf57_uc002ill.1_5'UTR|C17orf57_uc010daz.1_Frame_Shift_Ins_p.E83fs	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	83							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						TTTTTCAGGAGAAAAAAAAGTT	0.287													---	---	---								A	45419343	A	A	45419342	7	5	171	1	0	1	1	0	0	0	0	0	1872	943	33	0	257	0	C17orf57	17	45419342	Frame_Shift_Ins	INS	-	TCGA-CV-5434-01A-01D-1683-08	2479239	45419342	35775868	140	32288											
ERN1	2081	broad.mit.edu	37	chr17	62126509	62126509	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaagggtggctgccctcAgagattacgtagtaaaagac	14	7	11	9	1	1	2	1	0	0	2	1	3	1	2	2	2	2	3	2	2	6	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:62126509A>T	uc002jdz.2	-	18	2420	c.2307T>A	c.(2305-2307)TCT>TCA	p.S769S		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	769	Cytoplasmic (Potential).|Protein kinase.		S -> F (in a glioblastoma multiforme sample; somatic mutation).		activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.S769F(1)		central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						GGCTGCCCTCAGAGATTACGT	0.557													18	23					0	0	0	0	T	62126509	T	T	62126509	2	4	171	1	0	0	0	0	0	0	0	1	5261	175	7	5		5	ERN1	17	62126509	Silent	SNP	A	TCGA-CV-5434-01A-01D-1683-08	16707167	62126509	19068701	141	32289											
CACNG4	27092	broad.mit.edu	37	chr17	65026643	65026643	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacacaggtgacccgagtgaCaagcgggacgaagacaaaaa	18	2	12	9	3	0	3	0	2	0	1	0	6	0	4	1	2	2	0	1	2	5	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:65026643C>A	uc002jft.1	+	4	522	c.507C>A	c.(505-507)GAC>GAA	p.D169E		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	169	Extracellular (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			ACCCGAGTGACAAGCGGGACG	0.547													35	72					2.68265e-12	2.93156e-12	1	0	A	65026643	A	A	65026643	3	1	171	1	0	0	0	0	1	0	0	0	2571	477	17	4	521	4	CACNG4	17	65026643	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	2900134	65026643	16168567	142	32290											
ZACN	353174	broad.mit.edu	37	chr17	74077642	74077642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagctgaggctgaagaacaCggcgctcaagtccatcatcg	11	6	11	13	3	2	3	2	2	0	1	4	3	3	3	2	2	2	3	2	2	3	0	rs140656208	by1000genomes	TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:74077642C>T	uc002jqn.2	+	7	769	c.686C>T	c.(685-687)ACG>ATG	p.T229M	ZACN_uc002jqo.2_RNA|ZACN_uc010dgu.2_Intron|EXOC7_uc002jqp.1_3'UTR|EXOC7_uc010dgv.1_3'UTR|EXOC7_uc002jqs.2_3'UTR|EXOC7_uc002jqq.2_3'UTR|EXOC7_uc010wsw.1_3'UTR|EXOC7_uc010wsx.1_3'UTR|EXOC7_uc002jqr.2_3'UTR|EXOC7_uc010wsv.1_3'UTR	NM_180990	NP_851321	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	229	Extracellular (Potential).|Leu-rich.				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity				0						CTGAAGAACACGGCGCTCAAG	0.662													30	83					0	0	0	0	T	74077642	T	T	74077642	3	4	171	1	0	0	0	0	1	0	0	0	17578	536	19	1	712	1	ZACN	17	74077642	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	9050999	74077642	7117568	143	32291											
CCDC57	284001	broad.mit.edu	37	chr17	80121141	80121141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtccccgagcttcctgagtgCcagtccagaggatactgggc	7	8	13	13	1	0	2	0	1	0	1	3	4	3	3	5	2	3	1	5	2	1	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:80121141C>T	uc002kdz.1	-	14	2330	c.1975G>A	c.(1975-1977)GCA>ACA	p.A659T	CCDC57_uc002kdx.1_Missense_Mutation_p.A659T|CCDC57_uc010dik.1_Missense_Mutation_p.A167T	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	659										ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			TTCCTGAGTGCCAGTCCAGAG	0.587													4	119					0	0	0	0	T	80121141	T	T	80121141	3	4	171	1	0	0	0	0	1	0	0	0	2840	739	26	4	792	4	CCDC57	17	80121141	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	6043499	80121141	1074069	144	32292											
ZNF750	79755	broad.mit.edu	37	chr17	80790065	80790065	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagtccatttgcgacagacTtggaagaggctggcttcgcc	9	9	13	10	2	0	3	0	0	0	3	2	5	1	4	2	3	1	2	2	3	1	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr17:80790065T>A	uc002kga.2	-	2	577	c.266A>T	c.(265-267)AAG>ATG	p.K89M	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	89						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGCGACAGACTTGGAAGAGGC	0.557													22	52					0	0	0	0	A	80790065	A	A	80790065	3	1	171	1	0	0	0	0	1	0	0	0	18199	1609	56	5	1913	5	ZNF750	17	80790065	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	668924	80790065	405145	145	32293											
WDR7	23335	broad.mit.edu	37	chr18	54385258	54385258	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagtaggacttctaagtttgCgagagaaaaaatgcataatg	16	10	10	5	1	1	1	0	0	1	1	1	4	1	2	0	1	2	3	0	1	6	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr18:54385258C>T	uc002lgk.1	+	13	1853	c.1642C>T	c.(1642-1644)CGA>TGA	p.R548*	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Nonsense_Mutation_p.R548*	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	548										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TCTAAGTTTGCGAGAGAAAAA	0.408													21	35					0	0	0	0	T	54385258	T	T	54385258	4	4	171	1	0	0	0	0	0	1	0	0	17388	760	27	1	1688	1	WDR7	18	54385258	Nonsense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08		54385258	23691990	146	32294											
AP3D1	8943	broad.mit.edu	37	chr19	2121212	2121212	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactggctgcagatgtcaatGatcttggtgagcagctcgtc	8	11	13	9	1	2	3	1	2	1	1	4	4	2	3	0	2	3	4	0	2	1	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:2121212G>A	uc002luz.2	-	13	1423	c.1200C>T	c.(1198-1200)ATC>ATT	p.I400I	AP3D1_uc002luy.2_Silent_p.I309I|AP3D1_uc002lva.2_Silent_p.I400I	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	400	HEAT 8.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGATGTCAATGATCTTGGTGA	0.582													26	26					0	0	0	0	A	2121212	A	A	2121212	2	1	171	1	0	0	0	0	0	0	0	1	746	1280	45	2		2	AP3D1	19	2121212	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08		2121212	57007771	147	32295											
PIN1	5300	broad.mit.edu	37	chr19	9959816	9959816	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgtttgcgctgcggacggggGagatgagcgggcccgtgttc	4	8	19	10	6	0	2	0	1	0	1	1	4	0	3	1	4	3	3	1	4	0	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:9959816G>A	uc002mml.1	+	4	455	c.433G>A	c.(433-435)GAG>AAG	p.E145K	PIN1_uc002mmm.1_3'UTR|PIN1_uc002mmn.1_RNA	NM_006221	NP_006212	Q13526	PIN1_HUMAN	protein (peptidyl-prolyl cis/trans isomerase)	145	PpiC.				cell cycle|negative regulation of cell motility|negative regulation of ERK1 and ERK2 cascade|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of type I interferon production|positive regulation of Rho GTPase activity|positive regulation of ubiquitin-protein ligase activity|protein folding|regulation of mitosis|regulation of pathway-restricted SMAD protein phosphorylation	nucleoplasm	GTPase activating protein binding|mitogen-activated protein kinase kinase binding|peptidyl-prolyl cis-trans isomerase activity|phosphoserine binding|phosphothreonine binding			skin(1)	1						GCGGACGGGGGAGATGAGCGG	0.687													11	22					0	0	0	0	A	9959816	A	A	9959816	3	1	171	1	0	0	0	0	1	0	0	0	11985	1175	41	2	447	2	PIN1	19	9959816	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	7838604	9959816	49169167	148	32296											
KEAP1	9817	broad.mit.edu	37	chr19	10600447	10600447	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccccacggcataaaggagacGattgaggacagccacgccca	13	3	11	14	3	0	2	0	1	0	1	0	5	0	3	4	3	1	1	4	3	2	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:10600447G>A	uc002moq.1	-	4	1564	c.1408C>T	c.(1408-1410)CGT>TGT	p.R470C	KEAP1_uc002mop.1_Missense_Mutation_p.R188C|KEAP1_uc002mor.1_Missense_Mutation_p.R470C	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	470	Kelch 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TAAAGGAGACGATTGAGGACA	0.557													16	13					0	0	0	0	A	10600447	A	A	10600447	3	1	171	1	0	0	0	0	1	0	0	0	8180	1058	37	1	478	1	KEAP1	19	10600447	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	640631	10600447	48528536	149	32297											
SLC27A1	376497	broad.mit.edu	37	chr19	17597588	17597588	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctgggcttcgcgccgggCgacgtggtggccatcttcct	3	9	15	14	5	1	0	0	0	1	0	3	1	2	0	3	4	1	2	3	4	0	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:17597588C>T	uc002ngu.1	+	2	434	c.384C>T	c.(382-384)GGC>GGT	p.G128G	SLC27A1_uc002ngt.1_Intron|SLC27A1_uc010xpp.1_5'UTR	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	128	Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0						TCGCGCCGGGCGACGTGGTGG	0.697													6	9					0	0	0	0	T	17597588	T	T	17597588	2	4	171	1	0	0	0	0	0	0	0	1	14589	755	27	1		1	SLC27A1	19	17597588	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08	6997141	17597588	41531395	150	32298											
ZNF100	163227	broad.mit.edu	37	chr19	21948566	21948566	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttgctcccttgagaggaCacattccatacctcgggtca	9	10	8	14	1	1	1	1	1	0	1	4	3	3	2	3	2	2	1	3	2	1	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:21948566C>T	uc002nqi.2	-	2	225	c.26G>A	c.(25-27)TGT>TAT	p.C9Y		NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTGAGAGGACACATTCCATA	0.468													17	45					0	0	0	0	T	21948566	T	T	21948566	3	4	171	1	0	0	0	0	1	0	0	0	17780	478	17	4	1618	4	ZNF100	19	21948566	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	4350978	21948566	37180417	151	32299											
ZNF208	7757	broad.mit.edu	37	chr19	22155123	22155123	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgaattacctcatgtttagTaaggatggagaacatactaa	16	12	8	5	0	1	2	1	1	0	1	1	4	1	3	1	2	3	2	1	2	7	6			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:22155123T>G	uc002nqp.2	-	5	2562	c.2413A>C	c.(2413-2415)ACT>CCT	p.T805P	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCATGTTTAGTAAGGATGGAG	0.378													8	28					0	0	0	0	G	22155123	G	G	22155123	3	3	171	1	0	0	0	0	1	0	0	0	17833	1638	57	5	1133	5	ZNF208	19	22155123	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	206557	22155123	36973860	152	32300											
ZFP30	22835	broad.mit.edu	37	chr19	38127001	38127001	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgttatgacttttctgataCagaggaagagatgtgagttt	11	15	11	4	0	1	5	0	3	1	2	1	7	1	6	0	1	1	2	0	1	3	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:38127001C>G	uc002ogv.1	-	6	957	c.441G>C	c.(439-441)CTG>CTC	p.L147L	ZFP30_uc002ogw.1_Silent_p.L147L|ZFP30_uc002ogx.1_Silent_p.L147L|ZFP30_uc010xtt.1_Silent_p.L146L	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTTCTGATACAGAGGAAGAG	0.393													22	150					0	0	0	0	G	38127001	G	G	38127001	2	3	171	1	0	0	0	0	0	0	0	1	17711	465	17	4		4	ZFP30	19	38127001	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08	15971878	38127001	21001982	153	32301											
NUMBL	9253	broad.mit.edu	37	chr19	41188693	41188693	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acccacaggacagacttcacGgactttcggcccatctggag	10	7	10	14	2	2	1	1	0	1	1	3	4	2	4	2	4	0	0	2	4	0	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:41188693G>A	uc002oon.2	-	5	507	c.339C>T	c.(337-339)TCC>TCT	p.S113S	NUMBL_uc010xvq.1_Silent_p.S72S|NUMBL_uc002ooo.2_Silent_p.S113S|NUMBL_uc010xvr.1_Silent_p.S72S	NM_004756	NP_004747	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	113	PID.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			lung(3)|ovary(1)|breast(1)	5			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			CAGACTTCACGGACTTTCGGC	0.652													17	133					0	0	0	0	A	41188693	A	A	41188693	2	1	171	1	0	0	0	0	0	0	0	1	10806	1103	39	1		1	NUMBL	19	41188693	Silent	SNP	G	TCGA-CV-5434-01A-01D-1683-08	3061692	41188693	17940290	154	32302											
KDELR1	10945	broad.mit.edu	37	chr19	48887692	48887692	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgctcaccatgaacagctgCggcaagatggccactgactc	10	8	10	13	1	1	3	1	2	0	1	2	3	1	3	2	2	4	3	2	2	2	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:48887692C>T	uc002pjb.1	-	4	594	c.399G>A	c.(397-399)CCG>CCA	p.P133P	KDELR1_uc002pja.1_Silent_p.P71P	NM_006801	NP_006792	P24390	ERD21_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum	133	Helical; (Potential).				intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane|membrane fraction	KDEL sequence binding|protein binding|receptor activity				0		all_epithelial(76;2.48e-06)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Prostate(7;0.122)|Breast(70;0.203)		all cancers(93;0.000114)|OV - Ovarian serous cystadenocarcinoma(262;0.000136)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.0145)		TGAACAGCTGCGGCAAGATGG	0.582													10	8					0	0	0	0	T	48887692	T	T	48887692	2	4	171	1	0	0	0	0	0	0	0	1	8158	755	27	1		1	KDELR1	19	48887692	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08	7698999	48887692	10241291	155	32303											
KLK4	9622	broad.mit.edu	37	chr19	51411651	51411651	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggtcgtgccctccgccggcGcagaacatgctggggtggta	5	8	16	12	4	0	1	0	0	0	1	2	1	1	1	3	5	3	3	3	5	2	1			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:51411651G>T	uc002pua.1	-	4	576	c.576C>A	c.(574-576)TGC>TGA	p.C192*	KLK4_uc002pty.1_Intron|KLK4_uc002ptz.1_RNA|KLK4_uc002pub.1_Nonsense_Mutation_p.C97*|KLK4_uc002puc.1_RNA|KLK4_uc010eoi.1_3'UTR|KLK4_uc002pud.1_Nonsense_Mutation_p.C97*	NM_004917	NP_004908	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4 preproprotein	192	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		CTCCGCCGGCGCAGAACATGC	0.622													56	52					6.3091e-27	7.30891e-27	1	0	T	51411651	T	T	51411651	4	4	171	1	0	0	0	0	0	1	0	0	8445	1079	38	3	196	3	KLK4	19	51411651	Nonsense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	2523959	51411651	7717332	156	32304											
ZNF320	162967	broad.mit.edu	37	chr19	53384345	53384345	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgaatcctcctatgtcttTcaagatgtgatttgcgactg	9	16	8	8	1	2	3	1	2	1	1	4	4	4	3	2	0	1	0	2	0	4	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:53384345T>A	uc002qag.2	-	4	1225	c.1034A>T	c.(1033-1035)GAA>GTA	p.E345V	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.E291V|ZNF320_uc002qai.2_Missense_Mutation_p.E345V	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	345	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		CCTATGTCTTTCAAGATGTGA	0.428													66	25					0	0	0	0	A	53384345	A	A	53384345	3	1	171	1	0	0	0	0	1	0	0	0	17906	1783	62	5	499	5	ZNF320	19	53384345	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	1972694	53384345	5744638	157	32305											
TMEM150B	284417	broad.mit.edu	37	chr19	55831420	55831420	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtctcacctggaaattgcctAccacggaggtgcccagggca	9	7	12	13	1	1	0	1	0	1	0	2	2	1	2	4	4	3	1	4	4	2	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:55831420A>T	uc010esw.1	-	6	484	c.311T>A	c.(310-312)GTA>GAA	p.V104E	TMEM150B_uc010yfu.1_Missense_Mutation_p.V104E|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA|TMEM150B_uc002qki.2_Missense_Mutation_p.V104E	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	104	Helical; (Potential).					integral to membrane					0						GAAATTGCCTACCACGGAGGT	0.617													63	12					0	0	0	0	T	55831420	T	T	55831420	3	4	171	1	0	0	0	0	1	0	0	0	16134	391	14	5	402	5	TMEM150B	19	55831420	Missense_Mutation	SNP	A	TCGA-CV-5434-01A-01D-1683-08	2447075	55831420	3297563	158	32306											
ZSCAN1	284312	broad.mit.edu	37	chr19	58565249	58565249	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caccgaggaagaaagcccccCggagcaagggcccccgggag	11	0	15	15	3	0	1	0	0	0	1	0	5	0	4	6	4	2	1	6	4	3	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr19:58565249C>T	uc002qrc.1	+	6	1304	c.1057C>T	c.(1057-1059)CGG>TGG	p.R353W		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	353					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GAAAGCCCCCCGGAGCAAGGG	0.662													27	11					0	0	0	0	T	58565249	T	T	58565249	3	4	171	1	0	0	0	0	1	0	0	0	18293	643	23	1	1071	1	ZSCAN1	19	58565249	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	2733829	58565249	563734	159	32307											
SUN5	140732	broad.mit.edu	37	chr20	31583478	31583478	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcaatgagctggttcatgcTacctcggaggtcctggattt	7	12	13	9	1	1	1	1	1	0	0	3	3	2	3	2	5	3	4	2	5	2	3			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr20:31583478T>A	uc002wyi.2	-	8	574	c.481A>T	c.(481-483)AGC>TGC	p.S161C		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	161	Potential.				spermatogenesis					skin(1)	1						TGGTTCATGCTACCTCGGAGG	0.478													44	246					0	0	0	0	A	31583478	A	A	31583478	3	1	171	1	0	0	0	0	1	0	0	0	15460	1522	53	5	682	5	SUN5	20	31583478	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08		31583478	31442042	160	32308											
ZHX3	23051	broad.mit.edu	37	chr20	39832157	39832157	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaccaccttcacagctgacGttgtatttgaacacacagtg	11	11	8	11	1	1	3	1	3	0	0	1	3	1	3	2	0	2	3	2	0	2	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr20:39832157G>A	uc002xjs.1	-	3	1778	c.1400C>T	c.(1399-1401)ACG>ATG	p.T467M	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.T467M|ZHX3_uc002xjt.1_Missense_Mutation_p.T467M|ZHX3_uc002xju.1_Missense_Mutation_p.T467M|ZHX3_uc002xjv.1_Missense_Mutation_p.T467M|ZHX3_uc002xjw.1_Missense_Mutation_p.T467M|ZHX3_uc010ggg.1_Missense_Mutation_p.T467M	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	467	Required for homodimerization and interaction with NFYA.|Required for repressor activity.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				CACAGCTGACGTTGTATTTGA	0.542													6	20					0	0	0	0	A	39832157	A	A	39832157	3	1	171	1	0	0	0	0	1	0	0	0	17744	1145	40	1	1478	1	ZHX3	20	39832157	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	8248679	39832157	23193363	161	32309											
DIDO1	11083	broad.mit.edu	37	chr20	61512534	61512534	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acccctggaagcatctctctCgggcagggcaccctgggcac	7	6	12	16	1	2	0	0	0	2	0	4	1	2	1	3	4	1	4	3	4	1	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr20:61512534C>T	uc002ydr.1	-	16	5038	c.4774G>A	c.(4774-4776)GAG>AAG	p.E1592K	DIDO1_uc002yds.1_Missense_Mutation_p.E1592K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1592					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GCATCTCTCTCGGGCAGGGCA	0.711													13	15					0	0	0	0	T	61512534	T	T	61512534	3	4	171	1	0	0	0	0	1	0	0	0	4544	893	31	1	1952	1	DIDO1	20	61512534	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	21680377	61512534	1512986	162	32310											
PWP2	5822	broad.mit.edu	37	chr21	45535281	45535281	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgaatccaacagcctggacGtatgtccctttgccaagttc	9	12	8	12	1	0	1	0	1	0	0	3	2	2	2	4	1	3	2	4	1	4	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr21:45535281G>A	uc002zeb.2	+	6	696	c.606_splice	c.e6+1	p.D202_splice		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog							cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CAGCCTGGACGTATGTCCCTT	0.602													28	84					0	0	0	0	A	45535281	A	A	45535281	5	1	171	1	0	0	0	0	0	0	1	0	12909	1159	40	1	629	1	PWP2	21	45535281	Splice_Site	SNP	G	TCGA-CV-5434-01A-01D-1683-08		45535281	2594614	163	32311											
C21orf58	54058	broad.mit.edu	37	chr21	47737166	47737166	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccccttccacgttctgcCgttcttgctccagcttctgt	2	15	7	17	2	3	0	0	0	3	0	6	0	6	0	5	0	3	4	5	0	0	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr21:47737166C>A	uc002zjf.2	-	4	1460	c.326G>T	c.(325-327)CGG>CTG	p.R109L	C21orf58_uc002ziz.2_Missense_Mutation_p.R26L|C21orf58_uc002zja.2_5'UTR|C21orf58_uc011afw.1_Missense_Mutation_p.R26L|C21orf58_uc002zjc.2_5'UTR|C21orf58_uc011afx.1_5'UTR|C21orf58_uc010gqj.1_RNA|C21orf58_uc002zjg.1_RNA	NM_058180	NP_478060	P58505	CU058_HUMAN	hypothetical protein LOC54058	109										pancreas(1)	1	Breast(49;0.112)			Colorectal(79;0.239)		CACGTTCTGCCGTTCTTGCTC	0.597													10	9					0.000673444	0.000689711	1	0	A	47737166	A	A	47737166	3	1	171	1	0	0	0	0	1	0	0	0	2139	652	23	3	666	3	C21orf58	21	47737166	Missense_Mutation	SNP	C	TCGA-CV-5434-01A-01D-1683-08	2201885	47737166	392729	164	32312											
EP300	2033	broad.mit.edu	37	chr22	41566521	41566521	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cccaagcgactgcaggaatgGtacaaaaaaatgcttgacaa	17	6	9	9	1	0	1	0	1	0	0	0	3	0	2	1	2	4	3	1	2	7	2			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr22:41566521G>C	uc003azl.3	+	27	4793	c.4398G>C	c.(4396-4398)TGG>TGC	p.W1466C		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1466					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGCAGGAATGGTACAAAAAAA	0.473			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				30	50					0	0	0	0	C	41566521	C	C	41566521	3	2	171	1	0	0	0	0	1	0	0	0	5172	1270	44	4	4504	4	EP300	22	41566521	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08		41566521	9738045	165	32313											
PKDREJ	10343	broad.mit.edu	37	chr22	46654890	46654890	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaggtgaacaaaaaagttaTtaataattgcacagggattg	18	10	9	4	0	0	1	0	1	0	0	0	2	0	2	0	2	2	2	0	2	7	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chr22:46654890T>C	uc003bhh.2	-	1	4330	c.4330A>G	c.(4330-4332)ATA>GTA	p.I1444V		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1444	Helical; (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AAAAAAGTTATTAATAATTGC	0.378													17	55					0	0	0	0	C	46654890	C	C	46654890	3	2	171	1	0	0	0	0	1	0	0	0	12025	1493	52	5	2435	5	PKDREJ	22	46654890	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	5088369	46654890	4649676	166	32314											
CCNB3	85417	broad.mit.edu	37	chrX	50051787	50051787	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgacagtgatgatgcgttTgttatagagccaatgacttt	11	14	11	5	1	0	5	0	4	0	1	0	5	0	5	1	0	2	2	1	0	3	4	rs147712690	byFrequency	TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chrX:50051787T>A	uc004dox.3	+	6	916	c.618T>A	c.(616-618)TTT>TTA	p.F206L	CCNB3_uc004doy.2_Missense_Mutation_p.F206L|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	206					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					ATGATGCGTTTGTTATAGAGC	0.413													36	4					0	0	0	0	A	50051787	A	A	50051787	3	1	171	1	0	0	0	0	1	0	0	0	2929	1809	63	5	632	5	CCNB3	23	50051787	Missense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08		50051787	105218773	167	32315											
NXF5	55998	broad.mit.edu	37	chrX	101092763	101092763	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacacttacaggggtcttTgagaatttttatattcctgc	10	15	7	9	0	1	1	0	1	1	1	2	2	2	1	1	2	2	0	1	2	4	7			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chrX:101092763T>A	uc011mrk.1	-	14	1270	c.910A>T	c.(910-912)AAA>TAA	p.K304*	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	304	NTF2; truncated.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						CAGGGGTCTTTGAGAATTTTT	0.507													94	23					0	0	0	0	A	101092763	A	A	101092763	4	1	171	1	0	0	0	0	0	1	0	0	10840	1821	63	5	199	5	NXF5	23	101092763	Nonsense_Mutation	SNP	T	TCGA-CV-5434-01A-01D-1683-08	51040976	101092763	54177797	168	32316											
ZMAT1	84460	broad.mit.edu	37	chrX	101139651	101139651	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgtatctacgggtttccaAagaactctcttccatctttc	8	16	5	12	1	4	1	0	0	4	1	8	1	6	1	2	1	2	2	2	1	4	5			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chrX:101139651A>T	uc004eim.2	-	2	3733	c.235T>A	c.(235-237)TTG>ATG	p.L79M	ZMAT1_uc011mrl.1_Missense_Mutation_p.L250M|ZMAT1_uc004ein.2_Missense_Mutation_p.L79M|ZMAT1_uc011mrm.1_Missense_Mutation_p.L79M	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	79						nucleus	zinc ion binding			ovary(1)	1						CGGGTTTCCAAAGAACTCTCT	0.443													39	53					0	0	0	0	T	101139651	T	T	101139651	3	4	171	1	0	0	0	0	1	0	0	0	17758	11	1	5	1172	5	ZMAT1	23	101139651	Missense_Mutation	SNP	A	TCGA-CV-5434-01A-01D-1683-08	46888	101139651	54130909	169	32317											
COL4A5	1287	broad.mit.edu	37	chrX	107865911	107865911	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacattgattttaggtgatGatggcttgcagggtcagcca	10	12	12	7	0	1	3	1	3	0	0	1	3	1	3	1	3	2	2	1	3	1	4			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chrX:107865911G>A	uc004enz.1	+	33	2975	c.2773G>A	c.(2773-2775)GAT>AAT	p.D925N	COL4A5_uc011mso.1_Missense_Mutation_p.D925N|COL4A5_uc004eob.1_Missense_Mutation_p.D533N	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	925	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						TTTAGGTGATGATGGCTTGCA	0.413									Alport_syndrome_with_Diffuse_Leiomyomatosis				19	40					0	0	0	0	A	107865911	A	A	107865911	3	1	171	1	0	0	0	0	1	0	0	0	3709	1290	45	2	2903	2	COL4A5	23	107865911	Missense_Mutation	SNP	G	TCGA-CV-5434-01A-01D-1683-08	6726260	107865911	47404649	170	32318											
MTCP1	4515	broad.mit.edu	37	chrX	154294265	154294265	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaggtgatcgggtggagcCcccacatcctctcctgccat	7	8	11	15	1	1	2	0	1	1	1	4	3	2	3	5	3	2	0	5	3	0	0			TCGA-CV-5434-01A-01D-1683-08	TCGA-CV-5434-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	69ef7b45-cd0e-4d59-a0ee-35a8c830120c	adb3715b-8a29-42d5-8490-8a55d24b4360	g.chrX:154294265C>T	uc004fmz.2	-	2	647	c.21G>A	c.(19-21)GGG>GGA	p.G7G	MTCP1NB_uc004fmy.2_Intron	NM_001018025	NP_001018025	P56278	MTCP1_HUMAN	mature T-cell proliferation 1	7					cell proliferation					lung(1)	1	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGGGTGGAGCCCCCACATCCT	0.572			T	TRA@	T cell prolymphocytic leukemia								11	16					0	0	0	0	T	154294265	T	T	154294265	2	4	171	1	0	0	0	0	0	0	0	1	9968	610	22	4		4	MTCP1	23	154294265	Silent	SNP	C	TCGA-CV-5434-01A-01D-1683-08	46428354	154294265	976295	171	32319											
NBPF1	55672	broad.mit.edu	37	chr1	16902841	16902841	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggtcctgcccctgggaCttgtctggctcatccggagt	4	11	14	12	1	2	0	1	0	1	0	4	3	4	3	4	5	1	1	4	5	0	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:16902841C>A	uc009vos.1	-	19	2928	c.2040G>T	c.(2038-2040)AAG>AAT	p.K680N	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Missense_Mutation_p.K138N|NBPF1_uc010oce.1_Missense_Mutation_p.K409N	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	680						cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GCCCCTGGGACTTGTCTGGCT	0.582													18	653					3.01185e-09	3.35548e-09	1	0	A	16902841	A	A	16902841	3	1	172	1	0	0	0	0	1	0	0	0	10245	564	20	4	1428	4	NBPF1	1	16902841	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08		16902841	232347780	1	32320											
IGSF21	84966	broad.mit.edu	37	chr1	18691843	18691843	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaccgtgacctggatgacAccaagatgcagaagtcactg	12	7	11	11	1	1	4	1	2	0	2	1	5	1	5	3	1	2	2	3	1	2	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:18691843A>C	uc001bau.1	+	6	1050	c.667A>C	c.(667-669)ACC>CCC	p.T223P	IGSF21_uc001bav.1_Missense_Mutation_p.T44P	NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	223						extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CCTGGATGACACCAAGATGCA	0.652													16	47					0	0	0	0	C	18691843	C	C	18691843	3	2	172	1	0	0	0	0	1	0	0	0	7638	159	6	5	689	5	IGSF21	1	18691843	Missense_Mutation	SNP	A	TCGA-CV-5435-01A-01D-1683-08	1789002	18691843	230558778	2	32321											
CSMD2	114784	broad.mit.edu	37	chr1	34204867	34204867	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagatggagctgcccagctGgaggctgtccccaaaccgtt	8	7	14	12	1	0	1	0	0	0	1	1	4	1	3	4	4	4	4	4	4	1	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:34204867G>C	uc001bxn.1	-	15	2151	c.2122C>G	c.(2122-2124)CAG>GAG	p.Q708E	CSMD2_uc001bxm.1_Missense_Mutation_p.Q748E	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	708	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTGCCCAGCTGGAGGCTGTCC	0.572													32	101					0	0	0	0	C	34204867	C	C	34204867	3	2	172	1	0	0	0	0	1	0	0	0	3962	1357	47	4	8561	4	CSMD2	1	34204867	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	15513024	34204867	215045754	3	32322											
MACF1	23499	broad.mit.edu	37	chr1	39833905	39833905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actgagctcttgtggctttgCgctggacttgtgccagcatc	5	13	12	11	1	1	1	0	1	1	0	2	2	1	2	1	2	4	4	1	2	0	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:39833905C>T	uc010oiu.1	+	14	8308	c.8177C>T	c.(8176-8178)GCG>GTG	p.A2726V	MACF1_uc010ois.1_Missense_Mutation_p.A2224V|MACF1_uc001cda.1_Missense_Mutation_p.A2132V|MACF1_uc001cdc.1_Missense_Mutation_p.A1311V|MACF1_uc001cdb.1_Missense_Mutation_p.A1311V	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4291					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGTGGCTTTGCGCTGGACTTG	0.453													31	48					0	0	0	0	T	39833905	T	T	39833905	3	4	172	1	0	0	0	0	1	0	0	0	9195	768	27	1	13000	1	MACF1	1	39833905	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	5629038	39833905	209416716	4	32323											
CYP4X1	260293	broad.mit.edu	37	chr1	47515807	47515807	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttatcctcaagcccaagaaTgggatgtatttgcacctgaa	12	12	8	9	0	1	2	1	1	0	1	2	3	2	3	3	1	2	2	3	1	6	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:47515807T>G	uc001cqt.2	+	12	1741	c.1491T>G	c.(1489-1491)AAT>AAG	p.N497K	CYP4X1_uc001cqr.2_Missense_Mutation_p.N496K|CYP4X1_uc001cqs.2_Missense_Mutation_p.N432K	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	497						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						AGCCCAAGAATGGGATGTATT	0.408													19	116					0	0	0	0	G	47515807	G	G	47515807	3	3	172	1	0	0	0	0	1	0	0	0	4210	1461	51	5	1537	5	CYP4X1	1	47515807	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	7681902	47515807	201734814	5	32324											
ALG6	29929	broad.mit.edu	37	chr1	63879791	63879791	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagattaaggatattttGccacgtcacatccaattaat	14	13	6	8	1	1	2	1	1	0	1	2	3	2	3	2	1	1	0	2	1	5	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:63879791G>T	uc010oow.1	+	10	1181	c.876G>T	c.(874-876)TTG>TTT	p.L292F	ALG6_uc001daz.2_RNA|ALG6_uc009waj.2_Intron|ALG6_uc010oox.1_Missense_Mutation_p.L91F	NM_013339	NP_037471	Q9Y672	ALG6_HUMAN	dolichyl pyrophosphate Man9GlcNAc2	292					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity				0						AGGATATTTTGCCACGTCACA	0.274													19	45					3.62473e-10	4.20773e-10	1	0	T	63879791	T	T	63879791	3	4	172	1	0	0	0	0	1	0	0	0	522	1310	46	4	910	4	ALG6	1	63879791	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	16363984	63879791	185370830	6	32325											
LPPR4	9890	broad.mit.edu	37	chr1	99772407	99772407	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcaccccagtagagggcagCgaaattggctcagagacgct	11	6	13	11	2	2	2	2	0	0	2	2	4	2	2	2	2	1	4	2	2	2	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:99772407C>T	uc001dse.2	+	7	2239	c.2133C>T	c.(2131-2133)AGC>AGT	p.S711S	LPPR4_uc010oue.1_Silent_p.S653S	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	711							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TAGAGGGCAGCGAAATTGGCT	0.522													6	28					0	0	0	0	T	99772407	T	T	99772407	2	4	172	1	0	0	0	0	0	0	0	1	8977	767	27	1		1	LPPR4	1	99772407	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	35892616	99772407	149478214	7	32326											
OLFM3	118427	broad.mit.edu	37	chr1	102269859	102269859	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacagcacctggtggccatTgttccaggcatagagagctc	10	8	12	11	0	0	1	0	0	0	1	2	3	1	1	3	3	3	4	3	3	2	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:102269859T>C	uc001duf.2	-	6	1443	c.1372A>G	c.(1372-1374)AAT>GAT	p.N458D	OLFM3_uc001dug.2_Missense_Mutation_p.N438D|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.N363D|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	458	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TGGTGGCCATTGTTCCAGGCA	0.418													54	34					0	0	0	0	C	102269859	C	C	102269859	3	2	172	1	0	0	0	0	1	0	0	0	10908	1812	63	5	68	5	OLFM3	1	102269859	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	2497452	102269859	146980762	8	32327											
TRIM33	51592	broad.mit.edu	37	chr1	114964164	114964164	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtgggacctcggtttgcaTttgccatagttgctgtagta	6	15	13	7	1	0	0	0	0	0	0	1	1	0	1	2	3	3	6	2	3	3	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:114964164T>A	uc001eew.2	-	11	2039	c.1955A>T	c.(1954-1956)AAT>ATT	p.N652I	TRIM33_uc010owr.1_Missense_Mutation_p.N242I|TRIM33_uc010ows.1_Missense_Mutation_p.N260I|TRIM33_uc001eex.2_Missense_Mutation_p.N652I	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	652					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCGGTTTGCATTTGCCATAGT	0.502			T	RET	papillary thyroid								30	45					0	0	0	0	A	114964164	A	A	114964164	3	1	172	1	0	0	0	0	1	0	0	0	16574	1493	52	5	1468	5	TRIM33	1	114964164	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	12694305	114964164	134286457	9	32328											
FLG	2312	broad.mit.edu	37	chr1	152283935	152283935	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctgctcgtggtgggatcCttgtcttcgtccagtgctgg	2	14	14	11	2	1	0	0	0	1	0	5	1	3	1	3	3	3	2	3	3	0	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:152283935C>A	uc001ezu.1	-	3	3463	c.3427G>T	c.(3427-3429)GGA>TGA	p.G1143*	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1143	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGTGGGATCCTTGTCTTCGT	0.592									Ichthyosis				12	285					1.05317e-09	1.2057e-09	1	0	A	152283935	A	A	152283935	4	1	172	1	0	0	0	0	0	1	0	0	5954	690	24	4	8762	4	FLG	1	152283935	Nonsense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	37319771	152283935	96966686	10	32329											
ADAR	103	broad.mit.edu	37	chr1	154562371	154562371	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggtggctcagcatggctaTctggtcatggaaggtgctgc	6	10	15	10	1	3	0	2	0	1	0	3	1	3	1	1	6	3	4	1	6	2	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:154562371T>C	uc001ffh.2	-	8	2730	c.2530A>G	c.(2530-2532)ATA>GTA	p.I844V	ADAR_uc001ffj.2_Missense_Mutation_p.I799V|ADAR_uc001ffi.2_Missense_Mutation_p.I818V|ADAR_uc001ffk.2_Missense_Mutation_p.I549V	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	844					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		AGCATGGCTATCTGGTCATGG	0.552													22	16					0	0	0	0	C	154562371	C	C	154562371	3	2	172	1	0	0	0	0	1	0	0	0	281	1435	50	5	1182	5	ADAR	1	154562371	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	2278436	154562371	94688250	11	32330											
SEC16B	89866	broad.mit.edu	37	chr1	177909817	177909817	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactgcgtctttctaaaacCagaggatctgacagcttcag	11	10	8	12	1	4	2	1	1	3	1	4	3	4	3	2	1	3	1	2	1	2	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:177909817C>T	uc001gli.1	-	17	2145	c.2055G>A	c.(2053-2055)CTG>CTA	p.L685L	SEC16B_uc001glk.1_Silent_p.L362L|SEC16B_uc009wwy.1_Silent_p.L240L|SEC16B_uc001glh.1_Silent_p.L344L|SEC16B_uc009wwz.1_Silent_p.L344L|SEC16B_uc001glj.1_Silent_p.L686L	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	685					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						TTTCTAAAACCAGAGGATCTG	0.463													7	26					0	0	0	0	T	177909817	T	T	177909817	2	4	172	1	0	0	0	0	0	0	0	1	14052	581	21	4		4	SEC16B	1	177909817	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	23347446	177909817	71340804	12	32331											
CFH	3075	broad.mit.edu	37	chr1	196684815	196684815	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattggactatgaatgccatGatggttatgaaagcaatact	14	12	9	6	0	0	3	0	3	0	0	0	4	0	4	1	2	3	2	1	2	6	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:196684815G>T	uc001gtj.3	+	11	1852	c.1612G>T	c.(1612-1614)GAT>TAT	p.D538Y		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	538	Sushi 9.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TGAATGCCATGATGGTTATGA	0.289													27	112					3.65163e-15	4.4246e-15	1	0	T	196684815	T	T	196684815	3	4	172	1	0	0	0	0	1	0	0	0	3298	1290	45	2	1672	2	CFH	1	196684815	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	18774998	196684815	52565806	13	32332											
ASPM	259266	broad.mit.edu	37	chr1	197111716	197111716	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacctcgtttttataactctTagatttacttaatattggat	11	20	4	6	1	1	1	0	0	1	1	2	2	1	2	1	1	3	1	1	1	7	11			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:197111716T>C	uc001gtu.2	-	3	1923	c.1666A>G	c.(1666-1668)AAG>GAG	p.K556E	ASPM_uc001gtv.2_Missense_Mutation_p.K556E|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	556					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTATAACTCTTAGATTTACTT	0.353													42	54					0	0	0	0	C	197111716	C	C	197111716	3	2	172	1	0	0	0	0	1	0	0	0	1058	1763	61	5	8871	5	ASPM	1	197111716	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	426901	197111716	52138905	14	32333											
CNTN2	6900	broad.mit.edu	37	chr1	205038984	205038984	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggagtaccagaacggagaCggcttcggctacctgctgtc	8	7	14	12	4	0	2	0	0	0	2	2	4	0	3	2	4	4	4	2	4	3	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:205038984C>T	uc001hbr.2	+	18	2495	c.2226C>T	c.(2224-2226)GAC>GAT	p.D742D	CNTN2_uc001hbq.1_Silent_p.D633D|CNTN2_uc001hbs.2_Silent_p.D530D	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	742	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGAACGGAGACGGCTTCGGCT	0.667													85	143					0	0	0	0	T	205038984	T	T	205038984	2	4	172	1	0	0	0	0	0	0	0	1	3656	535	19	1		1	CNTN2	1	205038984	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	7927268	205038984	44211637	15	32334											
PFKFB2	5208	broad.mit.edu	37	chr1	207242833	207242833	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccagaagagtttgcacttcGagatcaagagaagtatctgt	13	10	10	8	1	2	4	1	0	1	4	3	6	2	4	1	0	1	3	1	0	4	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:207242833G>A	uc001hfg.2	+	11	1161	c.1052G>A	c.(1051-1053)CGA>CAA	p.R351Q	PFKFB2_uc010psc.1_Missense_Mutation_p.R253Q|PFKFB2_uc001hfh.2_Missense_Mutation_p.R351Q|PFKFB2_uc009xcc.2_Missense_Mutation_p.R309Q|PFKFB2_uc010psd.1_Missense_Mutation_p.R165Q	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	351	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					TTTGCACTTCGAGATCAAGAG	0.458													14	67					0	0	0	0	A	207242833	A	A	207242833	3	1	172	1	0	0	0	0	1	0	0	0	11816	1058	37	1	1090	1	PFKFB2	1	207242833	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	2203849	207242833	42007788	16	32335											
RPS6KC1	26750	broad.mit.edu	37	chr1	213414710	213414710	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	taaaatcagaacctttgaaaCcattctttactcttccagat	14	14	3	10	0	3	3	1	1	2	2	4	3	4	3	3	0	3	0	3	0	5	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:213414710C>G	uc010ptr.1	+	11	2050	c.1891C>G	c.(1891-1893)CCA>GCA	p.P631A	RPS6KC1_uc001hkd.2_Missense_Mutation_p.P619A|RPS6KC1_uc010pts.1_Missense_Mutation_p.P419A|RPS6KC1_uc010ptt.1_Missense_Mutation_p.P419A|RPS6KC1_uc010ptu.1_Missense_Mutation_p.P450A|RPS6KC1_uc010ptv.1_Missense_Mutation_p.P166A|RPS6KC1_uc001hke.2_Missense_Mutation_p.P450A	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	631					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		ACCTTTGAAACCATTCTTTAC	0.403													25	43					0	0	0	0	G	213414710	G	G	213414710	3	3	172	1	0	0	0	0	1	0	0	0	13723	507	18	4	1933	4	RPS6KC1	1	213414710	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	6171877	213414710	35835911	17	32336											
ZNF238	10472	broad.mit.edu	37	chr1	244217113	244217113	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atgaagacagtatggagtttCcagaccatagtagacatttg	14	11	10	6	0	0	4	0	1	0	3	1	5	1	5	2	1	0	3	2	1	4	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:244217113C>G	uc001iae.2	+	1	532	c.10C>G	c.(10-12)CCA>GCA	p.P4A	ZNF238_uc001iad.3_Missense_Mutation_p.P13A|ZNF238_uc001iaf.1_Missense_Mutation_p.P4A	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	4					negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			TATGGAGTTTCCAGACCATAG	0.473													3	44					0	0	0	0	G	244217113	G	G	244217113	3	3	172	1	0	0	0	0	1	0	0	0	17857	855	30	2	43	2	ZNF238	1	244217113	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	30802403	244217113	5033508	18	32337											
OR11L1	391189	broad.mit.edu	37	chr1	248004560	248004560	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacatagggccccagtgtCagaaaaaaacaaatgcacag	20	4	8	9	0	1	1	1	0	0	1	1	1	1	1	2	1	3	1	2	1	7	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:248004560C>A	uc001idn.1	-	1	639	c.639G>T	c.(637-639)CTG>CTT	p.L213L		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCCCCAGTGTCAGAAAAAAAC	0.507													28	39					1.16021e-09	1.31914e-09	1	0	A	248004560	A	A	248004560	2	1	172	1	0	0	0	0	0	0	0	1	10984	813	29	2		2	OR11L1	1	248004560	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	3787447	248004560	1246061	19	32338											
OR2T8	343172	broad.mit.edu	37	chr1	248084827	248084827	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcccatattgcggtgcaCacgagatcgatcacttcttc	8	12	8	13	3	2	1	1	0	1	1	5	3	3	1	1	1	2	2	1	1	1	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:248084827C>A	uc010pzc.1	+	1	508	c.508C>A	c.(508-510)CAC>AAC	p.H170N		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TTGCGGTGCACACGAGATCGA	0.567													3	24					3.07112e-06	3.28907e-06	1	0	A	248084827	A	A	248084827	3	1	172	1	0	0	0	0	1	0	0	0	11084	478	17	4	510	4	OR2T8	1	248084827	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	80267	248084827	1165794	20	32339											
OR2T33	391195	broad.mit.edu	37	chr1	248436609	248436609	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaagtgatcgatctcgtGtgcaccacaatatgggaagc	13	8	12	8	2	1	2	0	1	1	1	3	5	1	3	1	1	2	1	1	1	5	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr1:248436609G>T	uc010pzi.1	-	1	508	c.508C>A	c.(508-510)CAC>AAC	p.H170N		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCGATCTCGTGTGCACCACAA	0.557													4	44					4.68919e-08	5.12109e-08	1	0	T	248436609	T	T	248436609	3	4	172	1	0	0	0	0	1	0	0	0	11078	1377	48	4	457	4	OR2T33	1	248436609	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	351782	248436609	814012	21	32340											
C2orf16	84226	broad.mit.edu	37	chr2	27804812	27804812	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcagagaaaagccatcaCagtccctctgagagaagcca	14	5	8	14	0	3	3	2	1	1	2	4	5	4	3	4	0	2	0	4	0	3	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:27804812C>T	uc002rkz.3	+	1	5424	c.5373C>T	c.(5371-5373)CAC>CAT	p.H1791H	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1791	20.|27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					AAAGCCATCACAGTCCCTCTG	0.542													27	150					0	0	0	0	T	27804812	T	T	27804812	2	4	172	1	0	0	0	0	0	0	0	1	2167	477	17	4		4	C2orf16	2	27804812	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08		27804812	215394561	22	32341											
ADD2	119	broad.mit.edu	37	chr2	70901925	70901925	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatcgtctttggtatcctcGtctcccttggacatcagctg	6	14	9	12	2	3	0	1	0	2	0	7	2	4	1	2	2	1	2	2	2	2	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:70901925G>A	uc002sgz.2	-	14	2091	c.1626C>T	c.(1624-1626)GAC>GAT	p.D542D	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_Silent_p.D542D|ADD2_uc002sha.2_Silent_p.D236D|ADD2_uc002sgx.2_Silent_p.D542D|ADD2_uc010fdt.1_Silent_p.D542D	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	542					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						TGGTATCCTCGTCTCCCTTGG	0.557													46	30					0	0	0	0	A	70901925	A	A	70901925	2	1	172	1	0	0	0	0	0	0	0	1	305	1136	40	1		1	ADD2	2	70901925	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08	43097113	70901925	172297448	23	32342											
CCT7	10574	broad.mit.edu	37	chr2	73470213	73470213	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctatgtggaggaaggtttaCacccccagatcatcattcga	11	10	9	11	1	2	1	2	0	0	1	3	4	2	3	3	3	1	1	3	3	3	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:73470213C>T	uc002siz.2	+	4	451	c.349C>T	c.(349-351)CAC>TAC	p.H117Y	CCT7_uc002sja.2_Intron|CCT7_uc010yrf.1_Missense_Mutation_p.H73Y|CCT7_uc010feu.2_Intron|CCT7_uc010yrg.1_Missense_Mutation_p.H17Y|CCT7_uc010yrh.1_Silent_p.Y6Y|CCT7_uc010yri.1_Missense_Mutation_p.H30Y	NM_006429	NP_006420	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 isoform a	117					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding				0						GGAAGGTTTACACCCCCAGAT	0.517													6	74					0	0	0	0	T	73470213	T	T	73470213	3	4	172	1	0	0	0	0	1	0	0	0	2974	478	17	4	363	4	CCT7	2	73470213	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	2568288	73470213	169729160	24	32343											
TET3	200424	broad.mit.edu	37	chr2	74274034	74274049	+	Frame_Shift_Del	DEL	GATCTCTCCCCAAGAG	-	-																															ctcagctcagaggtgccccaGatctctccccaagagggcct																										TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:74274034_74274049delGATCTCTCCCCAAGAG	uc002skb.3	+	1	585_600	c.585_600delGATCTCTCCCCAAGAG	c.(583-600)CAGATCTCTCCCCAAGAGfs	p.Q195fs	TET3_uc010fez.1_Frame_Shift_Del_p.Q195fs	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	195_200							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AGGTGCCCCAGATCTCTCCCCAAGAGGGCCTGCCCC	0.644													---	---	---								-	74274049	-	-	74274034	7	5	172	1	0	1	0	1	0	0	0	0	15837	933	33	0	587	0	TET3	2	74274034	Frame_Shift_Del	DEL	GATCTCTCCCCAAGAG	TCGA-CV-5435-01A-01D-1683-08	803821	74274034	168925339	25	32344											
MOGS	7841	broad.mit.edu	37	chr2	74689333	74689333	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaggaaagccaagtcgtcaGggtcaccaacctctagcata	13	6	11	11	1	3	0	2	0	1	0	4	2	3	2	3	3	3	1	3	3	5	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:74689333G>T	uc010ffj.2	-	4	1746	c.1583C>A	c.(1582-1584)CCT>CAT	p.P528H	MOGS_uc010ffh.2_Missense_Mutation_p.P253H|MOGS_uc010yrt.1_Missense_Mutation_p.P409H|MOGS_uc010ffi.2_Missense_Mutation_p.P422H	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	528	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						CAAGTCGTCAGGGTCACCAAC	0.597													24	86					4.81078e-24	6.00443e-24	1	0	T	74689333	T	T	74689333	3	4	172	1	0	0	0	0	1	0	0	0	9750	1000	35	4	934	4	MOGS	2	74689333	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	415299	74689333	168510040	26	32345											
ANKRD36	375248	broad.mit.edu	37	chr2	97860475	97860475	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttttcagtgtcttctcggaAaaaaccagccttgaaggtaa	12	12	8	9	1	3	1	1	1	2	0	4	2	3	2	2	2	2	1	2	2	5	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:97860475A>G	uc010yva.1	+	39	2706	c.2462A>G	c.(2461-2463)AAA>AGA	p.K821R	ANKRD36_uc002sxo.2_Intron|ANKRD36_uc002sxp.3_RNA|ANKRD36_uc002sxq.1_Intron	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	821											0						TCTTCTCGGAAAAAACCAGCC	0.333													8	9					0	0	0	0	G	97860475	G	G	97860475	3	3	172	1	0	0	0	0	1	0	0	0	665	14	1	5	2616	5	ANKRD36	2	97860475	Missense_Mutation	SNP	A	TCGA-CV-5435-01A-01D-1683-08	23171142	97860475	145338898	27	32346											
POTEE	445582	broad.mit.edu	37	chr2	132021743	132021743	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggttcaccaccatggccgaGcgggaaatcgtgcgtgacat	10	7	13	11	4	1	1	1	1	0	0	2	3	1	2	3	3	2	1	3	3	1	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:132021743G>C	uc002tsn.2	+	15	2767	c.2715G>C	c.(2713-2715)GAG>GAC	p.E905D	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Missense_Mutation_p.E505D|POTEE_uc002tsl.2_Missense_Mutation_p.E487D|POTEE_uc010fmy.1_Missense_Mutation_p.E369D	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	905	Actin-like.						ATP binding				0						CCATGGCCGAGCGGGAAATCG	0.602													9	141					0	0	0	0	C	132021743	C	C	132021743	3	2	172	1	0	0	0	0	1	0	0	0	12319	962	34	4	2773	4	POTEE	2	132021743	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	34161268	132021743	111177630	28	32347											
PRKRA	8575	broad.mit.edu	37	chr2	179309173	179309173	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatgaaccaataggattaagCtggttctttggttgcttgga	11	14	11	5	0	1	1	0	1	1	0	1	3	1	3	1	4	3	4	1	4	5	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:179309173C>T	uc002umf.2	-	4	573	c.372G>A	c.(370-372)CAG>CAA	p.Q124Q	PRKRA_uc002umc.2_5'Flank|PRKRA_uc002umd.2_Silent_p.Q99Q|PRKRA_uc002ume.2_Silent_p.Q113Q|PRKRA_uc002umg.2_Silent_p.Q11Q	NM_003690	NP_003681	O75569	PRKRA_HUMAN	protein kinase, interferon-inducible double	124	Sufficient for self-association and interaction with TARBP2.				immune response|negative regulation of cell proliferation|production of siRNA involved in RNA interference|response to virus	perinuclear region of cytoplasm	double-stranded RNA binding|enzyme activator activity|protein homodimerization activity			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.00634)|all cancers(119;0.0265)			TAGGATTAAGCTGGTTCTTTG	0.358													24	31					0	0	0	0	T	179309173	T	T	179309173	2	4	172	1	0	0	0	0	0	0	0	1	12586	796	28	4		4	PRKRA	2	179309173	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	47287430	179309173	63890200	29	32348											
TTN	7273	broad.mit.edu	37	chr2	179430729	179430729	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttgacctttgcccctccAtcaatgatgggtggctccca	6	13	8	14	0	2	2	1	2	1	0	4	2	4	2	5	2	1	1	5	2	1	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:179430729A>G	uc010zfg.1	-	275	72650	c.72426T>C	c.(72424-72426)GAT>GAC	p.D24142D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.D17837D|TTN_uc010zfi.1_Silent_p.D17770D|TTN_uc010zfj.1_Silent_p.D17645D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25069							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCCCCTCCATCAATGATGG	0.433													33	132					0	0	0	0	G	179430729	G	G	179430729	2	3	172	1	0	0	0	0	0	0	0	1	16803	214	8	5		5	TTN	2	179430729	Silent	SNP	A	TCGA-CV-5435-01A-01D-1683-08	121556	179430729	63768644	30	32349											
PPP1R1C	151242	broad.mit.edu	37	chr2	182981993	182981993	+	Frame_Shift_Del	DEL	A	-	-																															ctgaagaagaagaaggcaccAatgaaagagaggagcagcgg																										TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:182981993delA	uc002uoo.2	+	5	588	c.301delA	c.(301-303)AATfs	p.N101fs	PPP1R1C_uc002uon.2_Intron|PPP1R1C_uc002uop.1_Frame_Shift_Del_p.N101fs|PPP1R1C_uc010frm.1_Frame_Shift_Del_p.N108fs|PPP1R1C_uc010frn.1_RNA	NM_001080545	NP_001074014	Q8WVI7	PPR1C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	101					signal transduction	cytoplasm	protein phosphatase inhibitor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0628)			AGAAGGCACCAATGAAAGAGA	0.368													---	---	---								-	182981993	-	-	182981993	7	5	172	1	0	1	0	1	0	0	0	0	12429	130	5	0	319	0	PPP1R1C	2	182981993	Frame_Shift_Del	DEL	A	TCGA-CV-5435-01A-01D-1683-08	3551264	182981993	60217380	31	32350											
ORC2L	4999	broad.mit.edu	37	chr2	201798644	201798644	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgcagtgttctatcagaGgttaaaacttttgaactgct	10	16	8	7	0	3	2	1	1	2	1	3	2	3	2	0	1	4	4	0	1	4	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:201798644G>C	uc002uwr.2	-	10	1019	c.762C>G	c.(760-762)ACC>ACG	p.T254T	ORC2L_uc010zhj.1_Silent_p.T254T	NM_006190	NP_006181	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2	254					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0						TTCTATCAGAGGTTAAAACTT	0.343													8	84					0	0	0	0	C	201798644	C	C	201798644	2	2	172	1	0	0	0	0	0	0	0	1	11316	987	35	4		4	ORC2L	2	201798644	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08	18816651	201798644	41400729	32	32351											
NDUFB3	4709	broad.mit.edu	37	chr2	201943659	201943659	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cataaaatggaacttccagaTtatagacaatggaagataga	19	9	8	5	0	0	4	0	0	0	4	1	6	1	6	1	2	1	0	1	2	8	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:201943659T>G	uc002uwx.3	+	2	377	c.54T>G	c.(52-54)GAT>GAG	p.D18E		NM_002491	NP_002482	O43676	NDUB3_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	18					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	AACTTCCAGATTATAGACAAT	0.408													4	49					0	0	0	0	G	201943659	G	G	201943659	3	3	172	1	0	0	0	0	1	0	0	0	10336	1490	52	5	56	5	NDUFB3	2	201943659	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	145015	201943659	41255714	33	32352											
TUBA4A	7277	broad.mit.edu	37	chr2	220115525	220115525	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cacactttaccatctggttgGcaggctcaaagcaggcattg	10	10	10	11	0	2	0	1	0	1	0	2	0	2	0	1	4	2	5	1	4	2	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:220115525G>A	uc002vkt.1	-	4	954	c.896C>T	c.(895-897)GCC>GTC	p.A299V	TUBA4A_uc010zkz.1_Missense_Mutation_p.A284V|TUBA4B_uc002vku.2_5'Flank|TUBA4B_uc002vkv.1_5'Flank	NM_006000	NP_005991	P68366	TBA4A_HUMAN	tubulin, alpha 4a	299					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)	3		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CATCTGGTTGGCAGGCTCAAA	0.572													18	83					0	0	0	0	A	220115525	A	A	220115525	3	1	172	1	0	0	0	0	1	0	0	0	16817	1203	42	4	454	4	TUBA4A	2	220115525	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	18171866	220115525	23083848	34	32353											
CUL3	8452	broad.mit.edu	37	chr2	225400286	225400286	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcatcaccatagctgtttGatgatcattccaagcttgat	12	14	6	9	0	3	3	3	3	0	0	4	3	4	3	2	0	2	3	2	0	3	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:225400286G>A	uc002vny.2	-	3	721	c.337C>T	c.(337-339)CAA>TAA	p.Q113*	CUL3_uc010zls.1_Nonsense_Mutation_p.Q47*|CUL3_uc010fwy.1_Nonsense_Mutation_p.Q119*	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	113					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ATAGCTGTTTGATGATCATTC	0.328													20	8					0	0	0	0	A	225400286	A	A	225400286	4	1	172	1	0	0	0	0	0	1	0	0	4073	1299	45	2	2025	2	CUL3	2	225400286	Nonsense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	5284761	225400286	17799087	35	32354											
GIGYF2	26058	broad.mit.edu	37	chr2	233660784	233660784	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttactagcaagctgagaaaAtggtggcttatctccaagac	13	10	10	8	0	1	2	0	1	1	2	2	3	1	2	1	2	3	4	1	2	7	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr2:233660784A>G	uc002vti.3	+	16	1829	c.1492A>G	c.(1492-1494)ATG>GTG	p.M498V	GIGYF2_uc010zmj.1_Missense_Mutation_p.M498V|GIGYF2_uc002vtg.2_Missense_Mutation_p.M492V|GIGYF2_uc002vtj.3_Missense_Mutation_p.M519V|GIGYF2_uc002vtk.3_Missense_Mutation_p.M498V|GIGYF2_uc002vth.3_Missense_Mutation_p.M492V|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.M329V	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	498					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		AGCTGAGAAAATGGTGGCTTA	0.383													14	64					0	0	0	0	G	233660784	G	G	233660784	3	3	172	1	0	0	0	0	1	0	0	0	6415	101	4	5	1608	5	GIGYF2	2	233660784	Missense_Mutation	SNP	A	TCGA-CV-5435-01A-01D-1683-08	8260498	233660784	9538589	36	32355											
SMARCC1	6599	broad.mit.edu	37	chr3	47680266	47680266	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccattttttcctcttcagcTccttctacaagtaaaagaat	11	16	3	11	0	3	1	1	0	2	1	6	1	6	1	3	0	2	2	3	0	5	7			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr3:47680266T>C	uc003crq.2	-	22	2443	c.2325A>G	c.(2323-2325)GGA>GGG	p.G775G	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Silent_p.G666G	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	775	Glu-rich.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		CCTCTTCAGCTCCTTCTACAA	0.328													46	22					0	0	0	0	C	47680266	C	C	47680266	2	2	172	1	0	0	0	0	0	0	0	1	14839	1538	54	5		5	SMARCC1	3	47680266	Silent	SNP	T	TCGA-CV-5435-01A-01D-1683-08		47680266	150342164	37	32356											
GPR27	2850	broad.mit.edu	37	chr3	71804252	71804252	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgagggactgcttcagggCccagttcccctgctgccaga	6	8	13	14	0	1	2	1	1	0	1	2	3	2	3	4	2	3	4	4	2	0	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr3:71804252C>T	uc011bge.1	+	1	1052	c.1052C>T	c.(1051-1053)GCC>GTC	p.A351V	EIF4E3_uc003dox.2_5'Flank|EIF4E3_uc011bgd.1_5'Flank|EIF4E3_uc010hoc.2_5'Flank	NM_018971	NP_061844	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	351	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		TGCTTCAGGGCCCAGTTCCCC	0.657													9	5					0	0	0	0	T	71804252	T	T	71804252	3	4	172	1	0	0	0	0	1	0	0	0	6723	739	26	4	1054	4	GPR27	3	71804252	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	24123986	71804252	126218178	38	32357											
OR5H2	79310	broad.mit.edu	37	chr3	98002139	98002139	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccatatgcaaacctttactAtatccagtgattatgaacaa	15	12	5	9	0	0	2	0	2	0	0	1	2	1	2	3	0	4	1	3	0	8	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr3:98002139A>G	uc003dsj.1	+	1	408	c.408A>G	c.(406-408)CTA>CTG	p.L136L		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						AACCTTTACTATATCCAGTGA	0.368													22	76					0	0	0	0	G	98002139	G	G	98002139	2	3	172	1	0	0	0	0	0	0	0	1	11216	436	16	5		5	OR5H2	3	98002139	Silent	SNP	A	TCGA-CV-5435-01A-01D-1683-08	26197887	98002139	100020291	39	32358											
KLF15	28999	broad.mit.edu	37	chr3	126071260	126071260	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagctgagagctggctgcagGcatccaagtccttgctgttg	7	10	13	11	0	0	1	0	1	0	1	2	2	2	1	2	2	4	7	2	2	1	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr3:126071260G>A	uc011bkk.1	-	2	688	c.506C>T	c.(505-507)GCC>GTC	p.A169V		NM_014079	NP_054798	Q9UIH9	KLF15_HUMAN	Kruppel-like factor 15	169						nucleus	DNA binding|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(114;0.147)		CTGGCTGCAGGCATCCAAGTC	0.612													25	22					0	0	0	0	A	126071260	A	A	126071260	3	1	172	1	0	0	0	0	1	0	0	0	8382	1203	42	4	752	4	KLF15	3	126071260	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	28069121	126071260	71951170	40	32359											
ASTE1	28990	broad.mit.edu	37	chr3	130743569	130743570	+	Frame_Shift_Ins	INS	-	G	G																															caagggaaaagcatttggcaINSgggatatagttttgtgtgcc																										TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr3:130743569_130743570insG	uc003env.1	-	3	1023_1024	c.581_582insC	c.(580-582)CCTfs	p.P194fs	NEK11_uc003enx.2_5'Flank|NEK11_uc003eny.2_5'Flank|NEK11_uc003eoa.2_5'Flank|NEK11_uc003enz.2_5'Flank|NEK11_uc010htn.2_5'Flank|NEK11_uc011blk.1_5'Flank|NEK11_uc011bll.1_5'Flank|NEK11_uc003enw.1_5'Flank|NEK11_uc011blm.1_5'Flank|ASTE1_uc010htm.1_Frame_Shift_Ins_p.P194fs|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	194					DNA repair		nuclease activity				0						AGCATTTGGCAGGGATATAGTT	0.396													---	---	---								G	130743570	G	G	130743569	7	5	172	1	0	1	1	0	0	0	0	0	1064	175	7	0	1473	0	ASTE1	3	130743569	Frame_Shift_Ins	INS	-	TCGA-CV-5435-01A-01D-1683-08	4672309	130743569	67278861	41	32360											
PLCH1	23007	broad.mit.edu	37	chr3	155199435	155199435	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcttgggtacagggacatgCatatcttgagcactagattg	10	12	12	7	0	1	2	0	1	1	1	1	3	1	3	0	2	4	4	0	2	3	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr3:155199435C>A	uc011bok.1	-	23	4681	c.4404G>T	c.(4402-4404)ATG>ATT	p.M1468I	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.M1430I	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1468					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CAGGGACATGCATATCTTGAG	0.473													14	121					4.3838e-07	4.7254e-07	1	0	A	155199435	A	A	155199435	3	1	172	1	0	0	0	0	1	0	0	0	12092	710	25	4	681	4	PLCH1	3	155199435	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	24455866	155199435	42822995	42	32361											
NLGN1	22871	broad.mit.edu	37	chr3	173998976	173998976	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaccattacaatgattccCaacactataccagggattca	16	9	4	12	0	1	1	1	1	0	0	2	2	2	2	3	1	4	0	3	1	6	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr3:173998976C>T	uc003fio.1	+	7	2778	c.2355C>T	c.(2353-2355)CCC>CCT	p.P785P	NLGN1_uc003fip.1_Silent_p.P785P	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	802	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CAATGATTCCCAACACTATAC	0.483													18	77					0	0	0	0	T	173998976	T	T	173998976	2	4	172	1	0	0	0	0	0	0	0	1	10515	581	21	4		4	NLGN1	3	173998976	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	18799541	173998976	24023454	43	32362											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			38	31					0	0	0	0	A	178936091	A	A	178936091	3	1	172	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	4937115	178936091	19086339	44	32363											
C3orf21	152002	broad.mit.edu	37	chr3	194790786	194790786	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggcagcccctcggggggCgggcccccaacccgggtctg	3	3	16	19	4	1	0	0	0	1	0	2	0	1	0	6	6	2	1	6	6	1	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr3:194790786C>T	uc003fum.3	-	4	948	c.840G>A	c.(838-840)CCG>CCA	p.P280P	C3orf21_uc003ful.2_Silent_p.P77P|C3orf21_uc003fuk.2_Silent_p.P74P	NM_152531	NP_689744	Q8NBI6	CC021_HUMAN	hypothetical protein LOC152002	280						integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)		CCTCGGGGGGCGGGCCCCCAA	0.677													22	87					0	0	0	0	T	194790786	T	T	194790786	2	4	172	1	0	0	0	0	0	0	0	1	2224	755	27	1		1	C3orf21	3	194790786	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	15854695	194790786	3231644	45	32364											
DLG1	1739	broad.mit.edu	37	chr3	196865135	196865135	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatttccattattttttctgAcactggtttccttcttttta	6	24	3	8	0	2	1	0	1	2	0	4	1	4	1	2	1	0	1	2	1	3	11			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr3:196865135A>C	uc003fxo.3	-	10	1130	c.940T>G	c.(940-942)TCA>GCA	p.S314A	DLG1_uc011bub.1_Missense_Mutation_p.S198A|DLG1_uc011buc.1_Missense_Mutation_p.S198A|DLG1_uc011bud.1_5'UTR|DLG1_uc003fxn.3_Missense_Mutation_p.S314A|DLG1_uc011bue.1_Missense_Mutation_p.S281A|DLG1_uc010ial.2_Missense_Mutation_p.S314A|DLG1_uc011buf.1_RNA|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Missense_Mutation_p.S281A|DLG1_uc010ian.2_Missense_Mutation_p.S181A	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	314					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		ATTTTTTCTGACACTGGTTTC	0.338													69	44					0	0	0	0	C	196865135	C	C	196865135	3	2	172	1	0	0	0	0	1	0	0	0	4576	275	10	5	1946	5	DLG1	3	196865135	Missense_Mutation	SNP	A	TCGA-CV-5435-01A-01D-1683-08	2074349	196865135	1157295	46	32365											
TXK	7294	broad.mit.edu	37	chr4	48096214	48096215	+	Nonsense_Mutation	DNP	CC	AA	AA																															ataatgttttatggcagcctCcgtacttctacaatcaagaa																										TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr4:48096214_48096215CC>AA	uc003gxx.3	-	8	674_675	c.588_589GG>TT	c.(586-591)ACGGAG>ACTTAG	p.E197*	TXK_uc003gxy.1_Nonsense_Mutation_p.E197*	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	197	SH2.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						ATGGCAGCCTCCGTACTTCTAC	0.371													4	30					0	0	0	0	AA	48096215	AA	AA	48096214	4	1	172	1	0	0	0	0	0	1	0	0	16854	864	30	2	1026	2	TXK	4	48096214	Nonsense_Mutation	DNP	CC	TCGA-CV-5435-01A-01D-1683-08		48096214	143058062	47	32366											
USP46	64854	broad.mit.edu	37	chr4	53470719	53470719	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcacaataatatttttgttCactacacagtgtttctgtgt	10	19	5	7	0	3	0	2	0	1	0	3	0	3	0	0	0	1	2	0	0	4	8			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr4:53470719C>T	uc003gzn.2	-	6	855	c.670G>A	c.(670-672)GAA>AAA	p.E224K	USP46_uc003gzm.3_Missense_Mutation_p.E217K|USP46_uc011bzr.1_Missense_Mutation_p.E201K|USP46_uc011bzs.1_Missense_Mutation_p.E108K	NM_022832	NP_073743	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46 isoform 1	224					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0295)			TATTTTTGTTCACTACACAGT	0.294													21	13					0	0	0	0	T	53470719	T	T	53470719	3	4	172	1	0	0	0	0	1	0	0	0	17145	835	29	2	446	2	USP46	4	53470719	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	5374505	53470719	137683557	48	32367											
UGT2A3	79799	broad.mit.edu	37	chr4	69796456	69796456	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccattcattccaccatgaGtgataaaagctttggttttg	10	15	7	9	0	1	2	1	2	0	0	3	2	3	2	3	1	1	2	3	1	2	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr4:69796456G>C	uc003hef.2	-	5	1143	c.1112C>G	c.(1111-1113)ACT>AGT	p.T371S	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	371	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TCCACCATGAGTGATAAAAGC	0.358													11	5					0	0	0	0	C	69796456	C	C	69796456	3	2	172	1	0	0	0	0	1	0	0	0	17023	1029	36	4	479	4	UGT2A3	4	69796456	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	16325737	69796456	121357820	49	32368											
PCDH10	57575	broad.mit.edu	37	chr4	134072873	134072873	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgagaacggctacttgtaCgccctgcgctccttcgacta	7	11	9	14	4	1	1	0	1	1	1	3	3	2	1	2	1	4	3	2	1	4	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr4:134072873C>T	uc003iha.2	+	1	2404	c.1578C>T	c.(1576-1578)TAC>TAT	p.Y526Y	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.Y526Y	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	526	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCTACTTGTACGCCCTGCGCT	0.592													18	52					0	0	0	0	T	134072873	T	T	134072873	2	4	172	1	0	0	0	0	0	0	0	1	11561	547	19	1		1	PCDH10	4	134072873	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	64276417	134072873	57081403	50	32369											
PRKAA1	5562	broad.mit.edu	37	chr5	40777689	40777689	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtcaattcatgtttgccaaCtgtaaaagaagtaatttaat	16	14	6	5	0	2	1	2	0	0	1	2	1	2	1	1	0	2	3	1	0	7	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr5:40777689C>G	uc003jmc.2	-	2	134	c.128_splice	c.e2-1	p.V43_splice	PRKAA1_uc003jmb.2_Splice_Site_p.V43_splice	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic						activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	TGTTTGCCAACTGTAAAAGAA	0.264													36	14					0	0	0	0	G	40777689	G	G	40777689	5	3	172	1	0	0	0	0	0	0	1	0	12555	579	20	4	1633	4	PRKAA1	5	40777689	Splice_Site	SNP	C	TCGA-CV-5435-01A-01D-1683-08		40777689	140137571	51	32370											
SH3RF2	153769	broad.mit.edu	37	chr5	145379827	145379827	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccccgctctgcagggccctCtacaacttcgacctacgagg	7	7	9	18	3	2	0	0	0	2	0	3	2	2	0	4	2	4	2	4	2	3	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr5:145379827C>G	uc003lnt.2	+	3	823	c.585C>G	c.(583-585)CTC>CTG	p.L195L	SH3RF2_uc011dbl.1_Silent_p.L195L	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	195	SH3 2.						ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAGGGCCCTCTACAACTTCG	0.602													14	11					0	0	0	0	G	145379827	G	G	145379827	2	3	172	1	0	0	0	0	0	0	0	1	14324	900	32	2		2	SH3RF2	5	145379827	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	104602138	145379827	35535433	52	32371											
FAT2	2196	broad.mit.edu	37	chr5	150924395	150924395	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccccatttgtccccaagTcctcatcagtggcagatacc	9	9	7	16	0	2	1	2	0	0	1	4	1	4	1	6	1	2	1	6	1	2	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr5:150924395T>C	uc003lue.3	-	9	6306	c.6293A>G	c.(6292-6294)GAC>GGC	p.D2098G	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2098	Extracellular (Potential).|Cadherin 18.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGTCCCCAAGTCCTCATCAGT	0.448													49	18					0	0	0	0	C	150924395	C	C	150924395	3	2	172	1	0	0	0	0	1	0	0	0	5722	1667	58	5	6816	5	FAT2	5	150924395	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	5544568	150924395	29990865	53	32372											
TDRD6	221400	broad.mit.edu	37	chr6	46661854	46661854	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgatgcctttgttctctGaggaagaaagcagtgatgga	11	12	12	6	0	1	4	0	3	1	1	2	6	1	6	1	2	2	2	1	2	2	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr6:46661854G>T	uc003oyj.2	+	1	5989	c.5989G>T	c.(5989-5991)GAG>TAG	p.E1997*	TDRD6_uc010jze.2_Nonsense_Mutation_p.E1991*	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1997					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TTTGTTCTCTGAGGAAGAAAG	0.313													11	124					0.00244969	0.00252577	1	0	T	46661854	T	T	46661854	4	4	172	1	0	0	0	0	0	1	0	0	15800	1291	45	2	5991	2	TDRD6	6	46661854	Nonsense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08		46661854	124453213	54	32373											
C7orf25	79020	broad.mit.edu	37	chr7	42949873	42949873	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctcatcatctgattcactCtcacttggttgaagctcttc	7	15	5	14	0	6	2	4	2	3	0	8	2	6	2	1	1	1	2	1	1	1	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr7:42949873C>G	uc003thw.2	-	2	1091	c.627G>C	c.(625-627)GAG>GAC	p.E209D	C7orf25_uc010kxq.2_Missense_Mutation_p.E209D|C7orf25_uc003thx.3_Missense_Mutation_p.E267D|C7orf25_uc010kxr.2_Missense_Mutation_p.E267D	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	209										skin(1)	1						CTGATTCACTCTCACTTGGTT	0.458													27	25					0	0	0	0	G	42949873	G	G	42949873	3	3	172	1	0	0	0	0	1	0	0	0	2391	912	32	2	642	2	C7orf25	7	42949873	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08		42949873	116188790	55	32374											
POR	5447	broad.mit.edu	37	chr7	75614935	75614935	+	Frame_Shift_Del	DEL	G	-	-																															cacatctgtgcggtggttgtGgagtacgagaccaaggctgg																										TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr7:75614935delG	uc003udy.2	+	13	1519	c.1437delG	c.(1435-1437)GTGfs	p.V479fs	POR_uc011kgc.1_Frame_Shift_Del_p.V287fs|POR_uc011kgd.1_Frame_Shift_Del_p.V378fs|POR_uc011kge.1_Frame_Shift_Del_p.V217fs|POR_uc003uea.2_5'UTR	NM_000941	NP_000932	P16435	NCPR_HUMAN	cytochrome P450 reductase	476	FAD-binding FR-type.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)	1					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	CGGTGGTTGTGGAGTACGAGA	0.697													---	---	---								-	75614935	-	-	75614935	7	5	172	1	0	1	0	1	0	0	0	0	12312	1335	47	0	1483	0	POR	7	75614935	Frame_Shift_Del	DEL	G	TCGA-CV-5435-01A-01D-1683-08	32665062	75614935	83523728	56	32375											
SAMD9L	219285	broad.mit.edu	37	chr7	92762231	92762231	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaatcatagaataaattCtcttctaatatattcaatgc	16	14	3	8	0	4	2	2	0	2	2	5	2	4	2	1	0	1	0	1	0	9	8			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr7:92762231C>A	uc003umh.1	-	5	4270	c.3054G>T	c.(3052-3054)GAG>GAT	p.E1018D	SAMD9L_uc003umj.1_Missense_Mutation_p.E1018D|SAMD9L_uc003umi.1_Missense_Mutation_p.E1018D|SAMD9L_uc010lfb.1_Missense_Mutation_p.E1018D|SAMD9L_uc003umk.1_Missense_Mutation_p.E1018D|SAMD9L_uc010lfc.1_Missense_Mutation_p.E1018D|SAMD9L_uc010lfd.1_Missense_Mutation_p.E1018D|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1018										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGAATAAATTCTCTTCTAATA	0.363													22	55					5.35356e-11	6.25838e-11	1	0	A	92762231	A	A	92762231	3	1	172	1	0	0	0	0	1	0	0	0	13892	912	32	2	1704	2	SAMD9L	7	92762231	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	17147296	92762231	66376432	57	32376											
CALCR	799	broad.mit.edu	37	chr7	93106945	93106945	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccggtgtgtcatcccagcAcagccatccatcccaggtgc	8	7	10	16	1	1	0	1	0	0	0	4	0	4	0	5	2	4	1	5	2	0	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr7:93106945A>G	uc003umv.1	-	5	556	c.295T>C	c.(295-297)TGC>CGC	p.C99R	CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.C81R|CALCR_uc003umw.2_Missense_Mutation_p.C81R	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	81	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TCATCCCAGCACAGCCATCCA	0.418													16	27					0	0	0	0	G	93106945	G	G	93106945	3	3	172	1	0	0	0	0	1	0	0	0	2591	159	6	5	1275	5	CALCR	7	93106945	Missense_Mutation	SNP	A	TCGA-CV-5435-01A-01D-1683-08	344714	93106945	66031718	58	32377											
SPDYE3	441272	broad.mit.edu	37	chr7	99917380	99917380	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagcgtcggttccagttCttctgttccatgcgctgcag	6	12	11	12	3	2	1	0	0	2	1	5	1	4	1	2	1	3	5	2	1	1	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr7:99917380C>A	uc003uug.1	+	4	648	c.408C>A	c.(406-408)TTC>TTA	p.F136L	uc011kjm.1_5'Flank	NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	513											0						GGTTCCAGTTCTTCTGTTCCA	0.607													32	66					4.74835e-14	5.71179e-14	1	0	A	99917380	A	A	99917380	3	1	172	1	0	0	0	0	1	0	0	0	15096	912	32	2	1573	2	SPDYE3	7	99917380	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	6810435	99917380	59221283	59	32378											
SRPK2	6733	broad.mit.edu	37	chr7	104808499	104808499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaggctgtctccgtataatGctgggcactttttacaactt	9	14	8	10	1	1	0	0	0	1	0	2	0	1	0	1	2	3	4	1	2	5	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr7:104808499G>A	uc003vct.2	-	4	536	c.349C>T	c.(349-351)CAT>TAT	p.H117Y	SRPK2_uc003vcu.2_Missense_Mutation_p.H117Y|SRPK2_uc003vcv.2_Missense_Mutation_p.H128Y|SRPK2_uc003vcw.1_Missense_Mutation_p.H117Y	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	117	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TCCGTATAATGCTGGGCACTT	0.279													14	27					0	0	0	0	A	104808499	A	A	104808499	3	1	172	1	0	0	0	0	1	0	0	0	15226	1319	46	4	1765	4	SRPK2	7	104808499	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	4891119	104808499	54330164	60	32379											
SSPO	23145	broad.mit.edu	37	chr7	149480698	149480698	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcctgtgcccggtgctgTctgcctatgcgcgtcgctgt	2	12	13	14	4	1	0	0	0	1	0	2	0	1	0	3	1	5	2	3	1	1	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr7:149480698T>C	uc010lpk.2	+	17	2404	c.2404T>C	c.(2404-2406)TCT>CCT	p.S802P	SSPO_uc010lpl.1_Missense_Mutation_p.S137P	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	802					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCGGTGCTGTCTGCCTATGC	0.637													37	82					0	0	0	0	C	149480698	C	C	149480698	3	2	172	1	0	0	0	0	1	0	0	0	15255	1667	58	5	2468	5	SSPO	7	149480698	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	44672199	149480698	9657965	61	32380											
PAXIP1	22976	broad.mit.edu	37	chr7	154767472	154767472	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttagtaatattcctcagtgtCcgtacagctggactccaggt	9	13	9	10	1	1	0	1	0	0	0	4	1	4	1	3	2	2	3	3	2	4	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr7:154767472C>T	uc003wlp.2	-	6	1051	c.1008G>A	c.(1006-1008)CGG>CGA	p.R336R	PAXIP1_uc003wlq.1_Silent_p.R302R|PAXIP1_uc011kvs.1_Silent_p.R300R|PAXIP1_uc003wlr.1_Silent_p.R245R	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	336					DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		TCCTCAGTGTCCGTACAGCTG	0.428													20	17					0	0	0	0	T	154767472	T	T	154767472	2	4	172	1	0	0	0	0	0	0	0	1	11541	842	30	2		2	PAXIP1	7	154767472	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	5286774	154767472	4371191	62	32381											
CSMD1	64478	broad.mit.edu	37	chr8	2820154	2820154	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggatgccagggtctccgcaGaacacagctatggaagataa	13	6	13	9	1	1	2	0	0	1	2	2	4	1	4	2	3	3	2	2	3	4	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr8:2820154G>A	uc011kwk.1	-	61	9855	c.9465C>T	c.(9463-9465)TTC>TTT	p.F3155F	CSMD1_uc011kwj.1_Silent_p.F2484F|CSMD1_uc010lrg.2_Silent_p.F1046F	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3155	Extracellular (Potential).|Sushi 26.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGTCTCCGCAGAACACAGCTA	0.463													3	14					0	0	0	0	A	2820154	A	A	2820154	2	1	172	1	0	0	0	0	0	0	0	1	3961	933	33	2		2	CSMD1	8	2820154	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08		2820154	143543868	63	32382											
XKR5	389610	broad.mit.edu	37	chr8	6679525	6679525	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgatgtcactctgctgggCgacaagccagaatgtcatca	11	9	11	10	1	4	2	3	1	1	1	4	4	4	2	1	1	2	1	1	1	2	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr8:6679525C>T	uc003wqp.2	-	5	695	c.673G>A	c.(673-675)GCC>ACC	p.A225T	XKR5_uc003wqq.2_Missense_Mutation_p.A62T|XKR5_uc003wqr.1_RNA	NM_207411	NP_997294	Q6UX68	XKR5_HUMAN	XK-related protein 5a	225	Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		CTCTGCTGGGCGACAAGCCAG	0.607													3	9					0	0	0	0	T	6679525	T	T	6679525	3	4	172	1	0	0	0	0	1	0	0	0	17502	768	27	1	1400	1	XKR5	8	6679525	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	3859371	6679525	139684497	64	32383											
PDE7A	5150	broad.mit.edu	37	chr8	66691976	66691976	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtggaaaatacgaaaatcaaTatatgggtgagaacctcttc	16	10	9	6	1	2	1	1	1	1	1	3	4	2	2	1	2	2	0	1	2	9	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr8:66691976T>C	uc003xvq.2	-	3	274	c.262A>G	c.(262-264)ATT>GTT	p.I88V	PDE7A_uc003xvr.2_Missense_Mutation_p.I88V|PDE7A_uc003xvp.2_Missense_Mutation_p.I62V	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	88						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	CGAAAATCAATATATGGGTGA	0.348													20	139					0	0	0	0	C	66691976	C	C	66691976	3	2	172	1	0	0	0	0	1	0	0	0	11705	1406	49	5	1262	5	PDE7A	8	66691976	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	60012451	66691976	79672046	65	32384											
VCPIP1	80124	broad.mit.edu	37	chr8	67576729	67576729	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggcattaactctttaggaGgaaacccgtatcgaatacac	13	10	9	9	2	1	0	0	0	1	0	2	3	1	2	1	3	3	2	1	3	6	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr8:67576729G>C	uc003xwn.2	-	1	2724	c.2465C>G	c.(2464-2466)CCT>CGT	p.P822R		NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	822					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			CTCTTTAGGAGGAAACCCGTA	0.383													28	125					0	0	0	0	C	67576729	C	C	67576729	3	2	172	1	0	0	0	0	1	0	0	0	17209	1000	35	4	1215	4	VCPIP1	8	67576729	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	884753	67576729	78787293	66	32385											
PHF20L1	51105	broad.mit.edu	37	chr8	133858165	133858165	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atagcaactctttgctctgtAtgacaacagtgaacacttaa	14	12	6	9	0	2	2	0	2	2	0	2	2	2	2	0	0	5	3	0	0	6	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr8:133858165A>G	uc003ytt.2	+	21	3376	c.3051A>G	c.(3049-3051)GTA>GTG	p.V1017V	PHF20L1_uc011lja.1_Silent_p.V991V	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	1017							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TTTGCTCTGTATGACAACAGT	0.388													21	13					0	0	0	0	G	133858165	G	G	133858165	2	3	172	1	0	0	0	0	0	0	0	1	11887	436	16	5		5	PHF20L1	8	133858165	Silent	SNP	A	TCGA-CV-5435-01A-01D-1683-08	66281436	133858165	12505857	67	32386											
OPLAH	26873	broad.mit.edu	37	chr8	145108284	145108284	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccttgcctggcgcccgcaggGcctccgtcaccgctggatgg	3	7	14	17	4	1	0	1	0	0	0	2	1	2	1	6	4	1	2	6	4	0	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr8:145108284G>T	uc003zar.3	-	20	2781	c.2699C>A	c.(2698-2700)GCC>GAC	p.A900D	OPLAH_uc003zas.1_Silent_p.G174G	NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	900							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CGCCCGCAGGGCCTCCGTCAC	0.647													8	93					0.00621372	0.00636714	1	0	T	145108284	T	T	145108284	3	4	172	1	0	0	0	0	1	0	0	0	10930	1203	42	4	1201	4	OPLAH	8	145108284	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	11250119	145108284	1255738	68	32387											
MPDZ	8777	broad.mit.edu	37	chr9	13147652	13147652	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatctctgaggtccattccAtccacctgcaatggaaggcc	9	9	9	14	0	1	1	0	1	1	0	5	2	4	2	5	3	1	2	5	3	2	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr9:13147652A>T	uc010mia.1	-	25	3693	c.3636T>A	c.(3634-3636)GAT>GAA	p.D1212E	MPDZ_uc010mhx.2_Intron|MPDZ_uc011lmm.1_Missense_Mutation_p.D104E|MPDZ_uc003zkz.3_Intron|MPDZ_uc010mhy.2_Missense_Mutation_p.D1212E|MPDZ_uc010mhz.2_Missense_Mutation_p.D1212E|MPDZ_uc011lmn.1_Missense_Mutation_p.D1212E|MPDZ_uc003zlb.3_Missense_Mutation_p.D1212E	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1212	PDZ 7.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		GGTCCATTCCATCCACCTGCA	0.428													24	19					0	0	0	0	T	13147652	T	T	13147652	3	4	172	1	0	0	0	0	1	0	0	0	9775	214	8	5	2573	5	MPDZ	9	13147652	Missense_Mutation	SNP	A	TCGA-CV-5435-01A-01D-1683-08		13147652	128065779	69	32388											
ANKS6	203286	broad.mit.edu	37	chr9	101552737	101552738	+	Missense_Mutation	DNP	CC	AA	AA																															gcctgaagggtggtgatggtCcacaaaggcaccggcttcca																										TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr9:101552737_101552738CC>AA	uc004ayu.2	-	2	531_532	c.510_511GG>TT	c.(508-513)GTGGAC>GTTTAC	p.D171Y	ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	171	ANK 4.									ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				TGGTGATGGTCCACAAAGGCAC	0.649													7	11					0	0	0	0	AA	101552738	AA	AA	101552737	3	1	172	1	0	0	0	0	1	0	0	0	692	855	30	2	2160	2	ANKS6	9	101552737	Missense_Mutation	DNP	CC	TCGA-CV-5435-01A-01D-1683-08	88405085	101552737	39660694	70	32389											
PRPF4	9128	broad.mit.edu	37	chr9	116038996	116038996	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgaagctggaaatattaatAtaacctctggtaagatgcaa	16	11	8	6	1	1	1	0	0	1	1	2	3	1	2	1	2	3	3	1	2	8	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr9:116038996A>G	uc004bgx.2	+	2	249	c.199A>G	c.(199-201)ATA>GTA	p.I67V	FKBP15_uc010muu.1_5'Flank|CDC26_uc004bgw.2_5'Flank|PRPF4_uc004bgy.2_Missense_Mutation_p.I66V	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	67						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						AAATATTAATATAACCTCTGG	0.388													87	101					0	0	0	0	G	116038996	G	G	116038996	3	3	172	1	0	0	0	0	1	0	0	0	12632	449	16	5	205	5	PRPF4	9	116038996	Missense_Mutation	SNP	A	TCGA-CV-5435-01A-01D-1683-08	14486259	116038996	25174435	71	32390											
ANKRD26	22852	broad.mit.edu	37	chr10	27352931	27352931	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttaccttctgcttgttcaTttcctatatttttttctttt	4	26	2	9	0	4	0	1	0	3	0	5	0	5	0	2	0	2	2	2	0	3	12			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr10:27352931T>C	uc001ith.2	-	12	1521	c.1349A>G	c.(1348-1350)AAT>AGT	p.N450S	ANKRD26_uc001itg.2_Missense_Mutation_p.N169S|ANKRD26_uc009xku.1_Missense_Mutation_p.N450S	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	450						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TGCTTGTTCATTTCCTATATT	0.323													21	15					0	0	0	0	C	27352931	C	C	27352931	3	2	172	1	0	0	0	0	1	0	0	0	654	1493	52	5	3875	5	ANKRD26	10	27352931	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08		27352931	108181816	72	32391											
HNRNPF	3185	broad.mit.edu	37	chr10	43882508	43882508	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaactcactgtcgccgtaTctgtggtcatacattccgga	8	12	10	11	3	3	1	2	1	1	0	5	2	4	2	2	2	2	1	2	2	3	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr10:43882508T>C	uc009xmh.1	-	3	1312	c.825A>G	c.(823-825)AGA>AGG	p.R275R	HNRNPF_uc001jar.2_Silent_p.R275R|HNRNPF_uc001jas.2_Silent_p.R275R|HNRNPF_uc001jat.2_Silent_p.R275R|HNRNPF_uc001jav.2_Silent_p.R275R|HNRNPF_uc001jau.2_Silent_p.R275R|uc010qfa.1_Missense_Mutation_p.S64P	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	275					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0						TGTCGCCGTATCTGTGGTCAT	0.557													19	16					0	0	0	0	C	43882508	C	C	43882508	2	2	172	1	0	0	0	0	0	0	0	1	7304	1432	50	5		5	HNRNPF	10	43882508	Silent	SNP	T	TCGA-CV-5435-01A-01D-1683-08	16529577	43882508	91652239	73	32392											
WDR11	55717	broad.mit.edu	37	chr10	122612036	122612036	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	taacattactgttttgctagGggctggcaaggtttaattgc	9	15	11	6	0	0	0	0	0	0	0	0	0	0	0	0	4	4	5	0	4	5	8			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr10:122612036G>A	uc010qtf.1	+	2	325	c.87G>A	c.(85-87)TGG>TGA	p.W29*	uc001lfb.1_5'Flank|WDR11_uc010qte.1_Nonsense_Mutation_p.W29*|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	29						integral to membrane					0						GTTTTGCTAGGGGCTGGCAAG	0.363													13	14					0	0	0	0	A	122612036	A	A	122612036	4	1	172	1	0	0	0	0	0	1	0	0	17341	1246	43	4	93	4	WDR11	10	122612036	Nonsense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	78729528	122612036	12922711	74	32393											
MUC6	4588	broad.mit.edu	37	chr11	1016020	1016020	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagaggagaaggcaggggCggtgtgggtgctggccgtgg	6	6	23	6	2	0	2	0	1	0	2	0	4	0	2	1	8	1	2	1	8	1	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr11:1016020C>T	uc001lsw.2	-	31	6832	c.6781G>A	c.(6781-6783)GCC>ACC	p.A2261T		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	2261	Ser-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAGGCAGGGGCGGTGTGGGTG	0.627													37	162					0	0	0	0	T	1016020	T	T	1016020	3	4	172	1	0	0	0	0	1	0	0	0	10033	768	27	1	550	1	MUC6	11	1016020	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08		1016020	133990496	75	32394											
OR5B17	219965	broad.mit.edu	37	chr11	58125655	58125655	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaccttcatgaatgcattCttcacgtctttgttcctcag	9	15	5	12	1	5	1	3	1	2	0	6	1	6	1	2	0	2	2	2	0	2	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr11:58125655C>A	uc010rke.1	-	1	888	c.888G>T	c.(886-888)AAG>AAT	p.K296N		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGAATGCATTCTTCACGTCTT	0.368													19	105					1.33834e-09	1.50111e-09	1	0	A	58125655	A	A	58125655	3	1	172	1	0	0	0	0	1	0	0	0	11203	912	32	2	58	2	OR5B17	11	58125655	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	57109635	58125655	76880861	76	32395											
DTX4	23220	broad.mit.edu	37	chr11	58956754	58956755	+	Frame_Shift_Ins	INS	-	C	C																															aaaatccatcccaggggtttINSccaacacaagccgcaagacc																										TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr11:58956754_58956755insC	uc001nns.2	+	4	1374_1375	c.1117_1118insC	c.(1117-1119)TCCfs	p.S373fs	DTX4_uc001nnr.2_Frame_Shift_Ins_p.S267fs	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	373					Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				CCCAGGGGTTTCCAACACAAGC	0.465													---	---	---								C	58956755	C	C	58956754	7	5	172	1	0	1	1	0	0	0	0	0	4819	1783	62	0	1131	0	DTX4	11	58956754	Frame_Shift_Ins	INS	-	TCGA-CV-5435-01A-01D-1683-08	831099	58956754	76049762	77	32396											
DDB1	1642	broad.mit.edu	37	chr11	61070101	61070101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcaccgagccttgtgtggggGtggaagtctcacccagattc	7	9	14	11	1	1	1	1	0	1	1	3	3	1	2	3	3	1	1	3	3	1	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr11:61070101G>A	uc001nrc.3	-	24	3291	c.3065C>T	c.(3064-3066)ACC>ATC	p.T1022I	DDB1_uc010rle.1_Missense_Mutation_p.T333I|DDB1_uc010rlf.1_Missense_Mutation_p.T1022I	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	1022	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						TTGTGTGGGGGTGGAAGTCTC	0.582								NER					90	117					0	0	0	0	A	61070101	A	A	61070101	3	1	172	1	0	0	0	0	1	0	0	0	4340	1261	44	4	373	4	DDB1	11	61070101	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	2113347	61070101	73936415	78	32397											
INTS5	80789	broad.mit.edu	37	chr11	62414590	62414590	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggtggaggacactgtgcaGcacagccagatggggtccac	9	5	16	11	1	0	1	0	0	0	1	1	3	1	3	2	5	3	2	2	5	0	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr11:62414590G>A	uc001nud.2	-	2	3015	c.2962C>T	c.(2962-2964)CTG>TTG	p.L988L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	988					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						ACACTGTGCAGCACAGCCAGA	0.602													4	148					0	0	0	0	A	62414590	A	A	62414590	2	1	172	1	0	0	0	0	0	0	0	1	7820	962	34	4		4	INTS5	11	62414590	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08	1344489	62414590	72591926	79	32398											
PRB1	5542	broad.mit.edu	37	chr12	11508453	11508453	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agttctgagctgagctcaggGccagcaaggccactgacagc	10	6	13	12	0	2	3	1	3	1	0	2	3	2	3	2	2	4	4	2	2	1	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:11508453G>T	uc001qzw.1	-	1	72	c.35C>A	c.(34-36)GCC>GAC	p.A12D	PRB1_uc001qzu.1_Missense_Mutation_p.A12D|PRB1_uc001qzv.1_Missense_Mutation_p.A12D	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	12						extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGAGCTCAGGGCCAGCAAGGC	0.502													6	45					5.18039e-06	5.51247e-06	1	0	T	11508453	T	T	11508453	3	4	172	1	0	0	0	0	1	0	0	0	12504	1203	42	4	972	4	PRB1	12	11508453	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08		11508453	122343442	80	32399											
GRIN2B	2904	broad.mit.edu	37	chr12	13717063	13717063	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagaatttgccgtacaggtCactgagctggctgtgcttgg	7	11	15	8	1	1	2	1	1	0	1	1	3	1	2	1	4	4	4	1	4	2	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:13717063C>T	uc001rbt.2	-	13	3288	c.3109G>A	c.(3109-3111)GAC>AAC	p.D1037N		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1037	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCGTACAGGTCACTGAGCTGG	0.582													25	16					0	0	0	0	T	13717063	T	T	13717063	3	4	172	1	0	0	0	0	1	0	0	0	6819	826	29	2	1349	2	GRIN2B	12	13717063	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	2208610	13717063	120134832	81	32400											
PDE3A	5139	broad.mit.edu	37	chr12	20523043	20523043	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcatttggggtcccagctGattgctgggaccaaggaaga	10	8	15	8	0	0	2	0	1	0	1	1	5	1	4	2	4	3	3	2	4	2	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:20523043G>A	uc001reh.1	+	1	847	c.825G>A	c.(823-825)CTG>CTA	p.L275L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	275					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGTCCCAGCTGATTGCTGGGA	0.627													16	60					0	0	0	0	A	20523043	A	A	20523043	2	1	172	1	0	0	0	0	0	0	0	1	11691	1277	45	2		2	PDE3A	12	20523043	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08	6805980	20523043	113328852	82	32401											
GXYLT1	283464	broad.mit.edu	37	chr12	42512903	42512903	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcaacatggtcatagtttCttccagtctttcaccacagg	9	14	6	12	0	5	0	3	0	2	0	6	0	6	0	2	2	1	1	2	2	2	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:42512903C>G	uc001rms.3	-	3	610	c.385G>C	c.(385-387)GAA>CAA	p.E129Q	GXYLT1_uc001rmt.3_Missense_Mutation_p.E98Q	NM_173601	NP_775872	Q4G148	GXLT1_HUMAN	glycosyltransferase 8 domain containing 3	129	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						GTCATAGTTTCTTCCAGTCTT	0.378													17	81					0	0	0	0	G	42512903	G	G	42512903	3	3	172	1	0	0	0	0	1	0	0	0	6942	922	32	2	961	2	GXYLT1	12	42512903	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	21989860	42512903	91338992	83	32402											
PRICKLE1	144165	broad.mit.edu	37	chr12	42864075	42864075	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcatgtggtggtaactggtaCaaaagctgtttaatccgatg	11	13	11	6	1	1	0	1	0	0	0	2	1	2	0	1	3	3	4	1	3	5	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:42864075C>A	uc010skv.1	-	3	506	c.219G>T	c.(217-219)TTG>TTT	p.L73F	PRICKLE1_uc001rnl.2_Missense_Mutation_p.L73F|PRICKLE1_uc010skw.1_Missense_Mutation_p.L73F|PRICKLE1_uc001rnm.2_Missense_Mutation_p.L73F|PRICKLE1_uc009zka.2_Missense_Mutation_p.L69F	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	73	PET.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GTAACTGGTACAAAAGCTGTT	0.398													9	47					0.000274275	0.00028635	1	0	A	42864075	A	A	42864075	3	1	172	1	0	0	0	0	1	0	0	0	12548	477	17	4	2300	4	PRICKLE1	12	42864075	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	351172	42864075	90987820	84	32403											
PTPRB	5787	broad.mit.edu	37	chr12	71029580	71029580	+	Frame_Shift_Del	DEL	A	-	-																															ttgtttctggagaaagagagAggcattttccacctcaagga																										TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:71029580delA	uc001swc.3	-	2	366	c.322delT	c.(322-324)TCTfs	p.S108fs	PTPRB_uc001swa.3_Frame_Shift_Del_p.S108fs|PTPRB_uc001swd.3_Frame_Shift_Del_p.S107fs|PTPRB_uc009zrr.1_Intron|PTPRB_uc001swe.2_Frame_Shift_Del_p.S108fs	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGAAAGAGAGAGGCATTTTCC	0.532													---	---	---								-	71029580	-	-	71029580	7	5	172	1	0	1	0	1	0	0	0	0	12861	304	11	0	6515	0	PTPRB	12	71029580	Frame_Shift_Del	DEL	A	TCGA-CV-5435-01A-01D-1683-08	28165505	71029580	62822315	85	32404											
TPH2	121278	broad.mit.edu	37	chr12	72416243	72416243	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaactgcgggcatatggagCaggactcctttcctccattg	8	10	11	12	1	0	0	0	0	0	0	3	2	3	2	3	3	3	3	3	3	2	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:72416243C>A	uc009zrw.1	+	9	1274	c.1133C>A	c.(1132-1134)GCA>GAA	p.A378E	TPH2_uc001swy.2_Missense_Mutation_p.A288E	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	378					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	GCATATGGAGCAGGACTCCTT	0.428													16	55					1.33834e-09	1.50111e-09	1	0	A	72416243	A	A	72416243	3	1	172	1	0	0	0	0	1	0	0	0	16469	710	25	4	1167	4	TPH2	12	72416243	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	1386663	72416243	61435652	86	32405											
PLXNC1	10154	broad.mit.edu	37	chr12	94634413	94634413	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctctgccacattgttcccTtatatttcctgctaccacct	6	16	4	15	0	1	0	0	0	1	0	3	0	3	0	5	0	4	3	5	0	3	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:94634413T>G	uc001tdc.2	+	11	2522	c.2273T>G	c.(2272-2274)CTT>CGT	p.L758R		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	758	Extracellular (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						CATTGTTCCCTTATATTTCCT	0.403													4	163					0	0	0	0	G	94634413	G	G	94634413	3	3	172	1	0	0	0	0	1	0	0	0	12181	1609	56	5	2315	5	PLXNC1	12	94634413	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	22218170	94634413	39217482	87	32406											
SLC25A3	5250	broad.mit.edu	37	chr12	98987764	98987764	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctcccctagaaagatgttctCgtccgtggcgcacctggcgc	6	9	11	15	4	1	2	0	0	1	2	4	2	3	2	4	2	0	2	4	2	2	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:98987764C>G	uc001tfo.2	+	2	128	c.8C>G	c.(7-9)TCG>TGG	p.S3W	SLC25A3_uc001tfm.2_Missense_Mutation_p.S3W|SLC25A3_uc001tfn.2_Missense_Mutation_p.S3W|SLC25A3_uc001tfp.2_Missense_Mutation_p.S3W|SLC25A3_uc001tfq.2_5'UTR|SLC25A3_uc001tfr.2_Missense_Mutation_p.S3W|SLC25A3_uc001tfs.2_5'UTR|SLC25A3_uc009ztn.2_Missense_Mutation_p.S3W|SLC25A3_uc001tft.2_Missense_Mutation_p.S3W	NM_005888	NP_005879	Q00325	MPCP_HUMAN	solute carrier family 25 member 3 isoform a	3					generation of precursor metabolites and energy	integral to plasma membrane|mitochondrial inner membrane	phosphate carrier activity|symporter activity				0		Lung NSC(355;4.08e-05)|Breast(359;0.00191)|Colorectal(145;0.00205)|Myeloproliferative disorder(1001;0.0255)		GBM - Glioblastoma multiforme(134;1.36e-23)|BRCA - Breast invasive adenocarcinoma(302;0.000115)		AAGATGTTCTCGTCCGTGGCG	0.662													11	29					0	0	0	0	G	98987764	G	G	98987764	3	3	172	1	0	0	0	0	1	0	0	0	14557	893	31	3	10	3	SLC25A3	12	98987764	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	4353351	98987764	34864131	88	32407											
CIT	11113	broad.mit.edu	37	chr12	120139472	120139472	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcgctgccctgcgctgttCacctgcacgattgagacagg	6	10	11	14	3	2	1	1	1	1	1	3	3	2	1	2	1	3	4	2	1	0	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:120139472C>T	uc001txi.1	-	42	5426	c.5373G>A	c.(5371-5373)GTG>GTA	p.V1791V	CIT_uc001txh.1_Silent_p.V1310V|CIT_uc001txj.1_Silent_p.V1833V	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1791	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTGCGCTGTTCACCTGCACGA	0.562													7	30					0	0	0	0	T	120139472	T	T	120139472	2	4	172	1	0	0	0	0	0	0	0	1	3453	813	29	2		2	CIT	12	120139472	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	21151708	120139472	13712423	89	32408											
CLIP1	6249	broad.mit.edu	37	chr12	122862371	122862371	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgggtttctccaagaaactgGataaatccaggcttatttcc	11	13	8	9	0	1	1	0	0	1	1	4	2	3	2	3	3	1	2	3	3	5	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:122862371G>C	uc001ucg.1	-	2	328	c.222C>G	c.(220-222)ATC>ATG	p.I74M	CLIP1_uc001uch.1_Missense_Mutation_p.I74M|CLIP1_uc001uci.1_Missense_Mutation_p.I74M|CLIP1_uc010tae.1_Missense_Mutation_p.I74M	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	74					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CAAGAAACTGGATAAATCCAG	0.483													124	53					0	0	0	0	C	122862371	C	C	122862371	3	2	172	1	0	0	0	0	1	0	0	0	3547	1164	41	2	4153	2	CLIP1	12	122862371	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	2722899	122862371	10989524	90	32409											
FAM101A	144347	broad.mit.edu	37	chr12	124799005	124799005	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcccagccgctggttcacCgccagcgtgcagctgcagct	5	6	13	17	4	1	0	1	0	0	0	1	0	1	0	4	2	6	6	4	2	0	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr12:124799005C>T	uc001ugd.1	+	3	585	c.342C>T	c.(340-342)ACC>ACT	p.T114T	FAM101A_uc001uge.1_Silent_p.T114T	NM_181709	NP_859060	Q6ZTI6	F101A_HUMAN	hypothetical protein LOC144347	195											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		GCTGGTTCACCGCCAGCGTGC	0.711													4	12					0	0	0	0	T	124799005	T	T	124799005	2	4	172	1	0	0	0	0	0	0	0	1	5408	639	23	1		1	FAM101A	12	124799005	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	1936634	124799005	9052890	91	32410											
JUB	84962	broad.mit.edu	37	chr14	23450638	23450639	+	Frame_Shift_Ins	INS	-	C	C																															aggcgaagcaaagctgttagINSctcgtcctggtaccgggcgc																										TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr14:23450638_23450639insC	uc001whz.2	-	1	1213_1214	c.837_838insG	c.(835-840)GAGCTAfs	p.E279fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	279_280	PreLIM.|Nuclear localization signal (Potential).				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		AAAGCTGTTAGCTCGTCCTGGT	0.713													---	---	---								C	23450639	C	C	23450638	7	5	172	1	0	1	1	0	0	0	0	0	8007	962	34	0	810	0	JUB	14	23450638	Frame_Shift_Ins	INS	-	TCGA-CV-5435-01A-01D-1683-08		23450638	83898902	92	32411											
RHOJ	57381	broad.mit.edu	37	chr14	63671683	63671683	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggtgggggacggtgccgtGgggaaaacctgcctgctgat	6	8	19	8	2	0	1	0	1	0	0	0	3	0	3	3	6	4	1	3	6	2	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr14:63671683G>C	uc001xgb.1	+	1	539	c.96G>C	c.(94-96)GTG>GTC	p.V32V		NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	ras homolog gene family, member J precursor	32	GTP (By similarity).				actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		ACGGTGCCGTGGGGAAAACCT	0.547													17	21					0	0	0	0	C	63671683	C	C	63671683	2	2	172	1	0	0	0	0	0	0	0	1	13406	1335	47	4		4	RHOJ	14	63671683	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08	40221045	63671683	43677857	93	32412											
PLEKHG3	26030	broad.mit.edu	37	chr14	65208842	65208842	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcctccccggaaagctcCtctcccactgaggggcgcag	7	6	11	17	2	1	1	0	1	1	0	4	2	3	2	5	3	2	2	5	3	1	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr14:65208842C>T	uc001xho.1	+	16	2876	c.2607C>T	c.(2605-2607)TCC>TCT	p.S869S	PLEKHG3_uc001xhn.1_Silent_p.S813S|PLEKHG3_uc001xhp.2_Silent_p.S990S|PLEKHG3_uc010aqh.1_Silent_p.S411S|PLEKHG3_uc001xhq.1_Silent_p.S374S	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	869					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CGGAAAGCTCCTCTCCCACTG	0.652													22	18					0	0	0	0	T	65208842	T	T	65208842	2	4	172	1	0	0	0	0	0	0	0	1	12125	668	24	4		4	PLEKHG3	14	65208842	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	1537159	65208842	42140698	94	32413											
ZFP36L1	677	broad.mit.edu	37	chr14	69256533	69256533	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaagggttattggtgccaTcgggcagggtaggtgagccc	9	8	16	8	1	0	1	0	1	0	0	1	1	0	1	2	5	2	3	2	5	4	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr14:69256533T>A	uc001xkh.1	-	2	864	c.734A>T	c.(733-735)GAT>GTT	p.D245V	ZFP36L1_uc001xki.1_Missense_Mutation_p.D245V	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	245					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		ATTGGTGCCATCGGGCAGGGT	0.592											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	80	111					0	0	0	0	A	69256533	A	A	69256533	3	1	172	1	0	0	0	0	1	0	0	0	17713	1435	50	5	286	5	ZFP36L1	14	69256533	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	4047691	69256533	38093007	95	32414											
ENTPD5	957	broad.mit.edu	37	chr14	74440651	74440651	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttccaaccatctcggtaaaCaggcactccggaaagtgtgc	11	8	9	13	2	1	0	0	0	1	0	4	1	3	1	3	3	3	2	3	3	4	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr14:74440651C>T	uc010tuo.1	-	12	1126	c.815G>A	c.(814-816)TGT>TAT	p.C272Y	ENTPD5_uc001xpi.2_Missense_Mutation_p.C272Y	NM_001249	NP_001240	O75356	ENTP5_HUMAN	ectonucleoside triphosphate diphosphohydrolase 5	272					'de novo' posttranslational protein folding|ATP metabolic process|cell growth|cell proliferation|glycolysis|protein N-linked glycosylation|regulation of phosphatidylinositol 3-kinase cascade	endoplasmic reticulum lumen	guanosine-diphosphatase activity|uridine-diphosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00394)		TCTCGGTAAACAGGCACTCCG	0.488													15	52					0	0	0	0	T	74440651	T	T	74440651	3	4	172	1	0	0	0	0	1	0	0	0	5166	478	17	4	491	4	ENTPD5	14	74440651	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	5184118	74440651	32908889	96	32415											
TTLL5	23093	broad.mit.edu	37	chr14	76286467	76286467	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctacacagtcagaccccCaagctcccgagaatcactcc	11	6	7	17	1	3	2	2	0	1	2	5	3	5	2	4	1	2	1	4	1	3	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr14:76286467C>G	uc001xrx.2	+	28	3494	c.3289C>G	c.(3289-3291)CAA>GAA	p.Q1097E	TTLL5_uc010ask.1_Missense_Mutation_p.Q1112E|TTLL5_uc001xrz.2_Missense_Mutation_p.Q672E|TTLL5_uc001xsa.2_Missense_Mutation_p.Q171E	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1097					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		GTCAGACCCCCAAGCTCCCGA	0.562													14	36					0	0	0	0	G	76286467	G	G	76286467	3	3	172	1	0	0	0	0	1	0	0	0	16798	595	21	4	3395	4	TTLL5	14	76286467	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	1845816	76286467	31063073	97	32416											
KIAA1409	57578	broad.mit.edu	37	chr14	94158111	94158111	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagacctccgtgctgcacaTgtgctccctcttccacgcgt	5	11	8	17	3	2	1	1	0	1	1	5	1	5	1	4	0	3	3	4	0	0	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr14:94158111T>C	uc001ybv.1	+	45	7024	c.6941T>C	c.(6940-6942)ATG>ACG	p.M2314T	KIAA1409_uc001ybs.1_Missense_Mutation_p.M2292T	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2469	Helical; (Potential).					integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GTGCTGCACATGTGCTCCCTC	0.532													7	53					0	0	0	0	C	94158111	C	C	94158111	3	2	172	1	0	0	0	0	1	0	0	0	8269	1464	51	5	7049	5	KIAA1409	14	94158111	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	17871644	94158111	13191429	98	32417											
OCA2	4948	broad.mit.edu	37	chr15	28326955	28326955	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgagtccgctgggcacggaCgtctgcaggagctccaccgc	6	5	15	15	5	1	0	0	0	1	0	3	3	3	2	3	3	2	4	3	3	0	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr15:28326955C>T	uc001zbh.3	-	2	176	c.66G>A	c.(64-66)ACG>ACA	p.T22T	OCA2_uc010ayv.2_Silent_p.T22T	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	22	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TGGGCACGGACGTCTGCAGGA	0.701									Oculocutaneous_Albinism				17	9					0	0	0	0	T	28326955	T	T	28326955	2	4	172	1	0	0	0	0	0	0	0	1	10869	523	19	1		1	OCA2	15	28326955	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08		28326955	74204437	99	32418											
THBS1	7057	broad.mit.edu	37	chr15	39884807	39884807	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcattggagatacctgtgaCaacaatcaggatattgatga	14	10	10	7	1	1	4	1	3	0	1	1	6	1	5	1	2	2	1	1	2	4	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr15:39884807C>G	uc001zkh.2	+	17	2750	c.2571C>G	c.(2569-2571)GAC>GAG	p.D857E	THBS1_uc010bbi.2_Missense_Mutation_p.D329E	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	857	TSP type-3 6.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	ATACCTGTGACAACAATCAGG	0.443													4	5					0	0	0	0	G	39884807	G	G	39884807	3	3	172	1	0	0	0	0	1	0	0	0	15919	477	17	4	2633	4	THBS1	15	39884807	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	11557852	39884807	62646585	100	32419											
CILP	8483	broad.mit.edu	37	chr15	65491100	65491100	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgttccccatgtacacatgGccaaagcgcatgggctcccc	8	8	9	16	1	0	0	0	0	0	0	2	0	2	0	5	2	2	4	5	2	2	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr15:65491100G>A	uc002aon.2	-	9	1705	c.1524C>T	c.(1522-1524)GGC>GGT	p.G508G		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	508					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TGTACACATGGCCAAAGCGCA	0.597													4	37					0	0	0	0	A	65491100	A	A	65491100	2	1	172	1	0	0	0	0	0	0	0	1	3444	1190	42	4		4	CILP	15	65491100	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08	25606293	65491100	37040292	101	32420											
ADAMTS7	11173	broad.mit.edu	37	chr15	79092702	79092702	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagcaggtgctgattggcGgtcaggttgaagcgcagctc	7	8	16	10	2	1	2	1	2	0	0	2	2	1	2	1	4	4	5	1	4	1	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr15:79092702G>A	uc002bej.3	-	2	499	c.288C>T	c.(286-288)ACC>ACT	p.T96T	ADAMTS7_uc010und.1_Silent_p.T96T|ADAMTS7_uc002bek.1_Silent_p.T96T	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	96					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						GCTGATTGGCGGTCAGGTTGA	0.587													4	6					0	0	0	0	A	79092702	A	A	79092702	2	1	172	1	0	0	0	0	0	0	0	1	271	1103	39	1		1	ADAMTS7	15	79092702	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08	13601602	79092702	23438690	102	32421											
RASGRF1	5923	broad.mit.edu	37	chr15	79294032	79294032	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttttgtttttgactgatttGggtgttgttggagatttagt	5	23	12	1	0	0	3	0	2	0	1	0	4	0	3	0	2	0	3	0	2	1	9			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr15:79294032G>T	uc002beq.2	-	17	2970	c.2595C>A	c.(2593-2595)CCC>CCA	p.P865P	RASGRF1_uc002bep.2_Silent_p.P849P|RASGRF1_uc010blm.1_Silent_p.P774P|RASGRF1_uc002ber.3_Silent_p.P849P|RASGRF1_uc010unh.1_Silent_p.P260P|RASGRF1_uc002beo.2_Silent_p.P81P	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	867					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						TGACTGATTTGGGTGTTGTTG	0.408													24	93					2.48779e-11	2.92889e-11	1	0	T	79294032	T	T	79294032	2	4	172	1	0	0	0	0	0	0	0	1	13137	1335	47	4		4	RASGRF1	15	79294032	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08	201330	79294032	23237360	103	32422											
ZNF500	26048	broad.mit.edu	37	chr16	4815844	4815844	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gagctggcggaaagtctcagGgctggggtcctccgtctcca	6	8	15	12	2	2	0	1	0	2	0	6	2	4	1	3	5	1	2	3	5	1	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr16:4815844G>C	uc002cxp.1	-	2	383	c.136C>G	c.(136-138)CCT>GCT	p.P46A	ZNF500_uc002cxo.1_5'UTR|ZNF500_uc010uxt.1_Missense_Mutation_p.P46A	NM_021646	NP_067678	O60304	ZN500_HUMAN	zinc finger protein 500	46					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						AAAGTCTCAGGGCTGGGGTCC	0.642													14	46					0	0	0	0	C	4815844	C	C	4815844	3	2	172	1	0	0	0	0	1	0	0	0	18015	1232	43	4	1326	4	ZNF500	16	4815844	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08		4815844	85538909	104	32423											
GPRC5B	51704	broad.mit.edu	37	chr16	19871833	19871833	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagtctttcaccaaaggtGtcttcctgtgtgacttggcg	8	14	10	9	1	3	1	1	1	2	0	4	1	4	1	2	2	0	0	2	2	3	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr16:19871833G>A	uc002dgt.2	-	4	1309	c.1201C>T	c.(1201-1203)CAC>TAC	p.H401Y	GPRC5B_uc010vav.1_Missense_Mutation_p.H427Y	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	401	Cytoplasmic (Potential).									lung(1)|breast(1)|skin(1)	3						CACCAAAGGTGTCTTCCTGTG	0.443													15	33					0	0	0	0	A	19871833	A	A	19871833	3	1	172	1	0	0	0	0	1	0	0	0	6764	1377	48	4	14	4	GPRC5B	16	19871833	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	15055989	19871833	70482920	105	32424											
VPS35	55737	broad.mit.edu	37	chr16	46716023	46716023	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactctttggtgataacataGaagtccggagttcaccaagc	13	10	9	9	1	2	2	1	1	1	1	3	3	3	3	2	2	3	1	2	2	5	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr16:46716023G>A	uc002eef.3	-	3	266	c.167C>T	c.(166-168)TCT>TTT	p.S56F	VPS35_uc002eed.2_5'Flank|VPS35_uc002eee.2_Missense_Mutation_p.S17F	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	56					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TGATAACATAGAAGTCCGGAG	0.338													18	35					0	0	0	0	A	46716023	A	A	46716023	3	1	172	1	0	0	0	0	1	0	0	0	17271	942	33	2	2283	2	VPS35	16	46716023	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	26844190	46716023	43638730	106	32425											
GPR172B	55065	broad.mit.edu	37	chr17	4937602	4937602	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acagggtcaccaccagcagaCccaggtttcccagcgccaca	11	4	9	17	1	1	1	1	0	0	1	2	1	2	1	5	2	2	2	5	2	0	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:4937602C>A	uc002gap.3	-	3	895	c.182G>T	c.(181-183)GGT>GTT	p.G61V	GPR172B_uc002gao.3_Missense_Mutation_p.G61V|GPR172B_uc010ckw.2_5'UTR|GPR172B_uc010ckx.2_Missense_Mutation_p.G61V	NM_001104577	NP_001098047	Q9NWF4	RFT_HUMAN	G protein-coupled receptor 172B precursor	61	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0						CACCAGCAGACCCAGGTTTCC	0.627													30	54					4.34311e-12	5.14968e-12	1	0	A	4937602	A	A	4937602	3	1	172	1	0	0	0	0	1	0	0	0	6708	507	18	4	1176	4	GPR172B	17	4937602	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08		4937602	76257608	107	32426											
TP53	7157	broad.mit.edu	37	chr17	7579415	7579415	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacagaagatgacaggggcCaggagggggctggtgcaggg	10	3	22	6	0	0	3	0	1	0	2	0	5	0	5	1	8	1	2	1	8	1	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:7579415C>T	uc002gim.2	-	4	466	c.272G>A	c.(271-273)TGG>TAG	p.W91*	TP53_uc002gig.1_Nonsense_Mutation_p.W91*|TP53_uc002gih.2_Nonsense_Mutation_p.W91*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.W91*|TP53_uc010cni.1_Nonsense_Mutation_p.W91*|TP53_uc002gij.2_Nonsense_Mutation_p.W91*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.W52*|TP53_uc010cnk.1_Nonsense_Mutation_p.W106*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	91	Interaction with WWOX.		W -> C (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W91*(11)|p.0?(7)|p.G59fs*23(3)|p.V73fs*9(1)|p.D48fs*55(1)|p.W91fs*57(1)|p.A88fs*52(1)|p.W91fs*13(1)|p.P87fs*54(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGACAGGGGCCAGGAGGGGGC	0.632		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			81	17					0	0	0	0	T	7579415	T	T	7579415	4	4	172	1	0	0	0	0	0	1	0	0	16448	595	21	4	1030	4	TP53	17	7579415	Nonsense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	2641813	7579415	73615795	108	32427											
DNAH9	1770	broad.mit.edu	37	chr17	11660996	11660996	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttccaacctgcctagacAcactcagaaccaggtaggcc	12	7	7	15	0	2	2	1	0	1	2	3	2	3	2	5	2	3	1	5	2	4	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:11660996A>G	uc002gne.2	+	35	7050	c.6982A>G	c.(6982-6984)ACA>GCA	p.T2328A	DNAH9_uc010coo.2_Missense_Mutation_p.T1622A	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2328	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTGCCTAGACACACTCAGAAC	0.468													20	15					0	0	0	0	G	11660996	G	G	11660996	3	3	172	1	0	0	0	0	1	0	0	0	4630	159	6	5	7120	5	DNAH9	17	11660996	Missense_Mutation	SNP	A	TCGA-CV-5435-01A-01D-1683-08	4081581	11660996	69534214	109	32428											
ATAD5	79915	broad.mit.edu	37	chr17	29162894	29162894	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtcaactagaagatctggaAgaattagcagcacacctact	16	8	8	9	0	2	3	1	0	1	3	2	4	2	4	1	1	4	2	1	1	7	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:29162894A>C	uc002hfs.1	+	2	2141	c.1795A>C	c.(1795-1797)AGA>CGA	p.R599R	ATAD5_uc002hft.1_Silent_p.R496R	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	599					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AAGATCTGGAAGAATTAGCAG	0.398													24	87					0	0	0	0	C	29162894	C	C	29162894	2	2	172	1	0	0	0	0	0	0	0	1	1078	64	3	5		5	ATAD5	17	29162894	Silent	SNP	A	TCGA-CV-5435-01A-01D-1683-08	17501898	29162894	52032316	110	32429											
STAC2	342667	broad.mit.edu	37	chr17	37369370	37369370	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgggaagaagccaacccGgtcgccgatcttgccctggg	8	6	14	13	3	1	1	0	0	1	1	2	3	1	2	4	3	4	1	4	3	3	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:37369370G>T	uc002hrs.2	-	10	1228	c.1009C>A	c.(1009-1011)CGG>AGG	p.R337R	STAC2_uc010cvt.2_Silent_p.R195R	NM_198993	NP_945344	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	337	SH3.				intracellular signal transduction		metal ion binding			pancreas(1)	1						AAGCCAACCCGGTCGCCGATC	0.607													28	32					1.77063e-15	2.17722e-15	1	0	T	37369370	T	T	37369370	2	4	172	1	0	0	0	0	0	0	0	1	15306	1115	39	3		3	STAC2	17	37369370	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08	8206476	37369370	43825840	111	32430											
WNT3	7473	broad.mit.edu	37	chr17	44845973	44845973	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgaagagcgagtacttggCccggagggtctccacccagc	8	7	13	13	2	1	2	0	1	1	1	2	4	1	3	3	3	3	1	3	3	2	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:44845973C>G	uc002ikv.2	-	4	900	c.781G>C	c.(781-783)GCC>CCC	p.A261P		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	261					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GAGTACTTGGCCCGGAGGGTC	0.592													51	60					0	0	0	0	G	44845973	G	G	44845973	3	3	172	1	0	0	0	0	1	0	0	0	17456	739	26	4	290	4	WNT3	17	44845973	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	7476603	44845973	36349237	112	32431											
COL1A1	1277	broad.mit.edu	37	chr17	48273527	48273527	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactcacagggggcccggCagcaccagtagcaccatcat	11	4	10	16	1	2	0	2	0	0	0	2	0	2	0	3	3	2	4	3	3	1	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:48273527C>T	uc002iqm.2	-	15	1117	c.991G>A	c.(991-993)GCC>ACC	p.A331T		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	331	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	GGGGGCCCGGCAGCACCAGTA	0.612			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						11	19					0	0	0	0	T	48273527	T	T	48273527	3	4	172	1	0	0	0	0	1	0	0	0	3692	710	25	4	3551	4	COL1A1	17	48273527	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	3427554	48273527	32921683	113	32432											
MED13	9969	broad.mit.edu	37	chr17	60087936	60087936	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgatgttacactttcctGtccaaaaggtccaactggat	12	12	7	10	0	0	1	0	1	0	0	3	2	3	2	3	2	3	1	3	2	5	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:60087936G>T	uc002izo.2	-	9	2019	c.1942C>A	c.(1942-1944)CAG>AAG	p.Q648K	MED13_uc002izp.2_Missense_Mutation_p.Q264K	NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	648					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						ACACTTTCCTGTCCAAAAGGT	0.348													8	38					1.12685e-05	1.18391e-05	1	0	T	60087936	T	T	60087936	3	4	172	1	0	0	0	0	1	0	0	0	9483	1386	48	4	4670	4	MED13	17	60087936	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	11814409	60087936	21107274	114	32433											
GH2	2689	broad.mit.edu	37	chr17	61958159	61958159	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcgtttggatgccttcctcTaggtccttcaggtggcgata	6	13	12	10	2	2	0	1	0	1	0	4	2	4	1	3	4	2	1	3	4	2	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:61958159T>C	uc002jco.1	-	4	491	c.429A>G	c.(427-429)CTA>CTG	p.L143L	GH2_uc002jcj.2_Silent_p.L143L|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_Silent_p.L143L|GH2_uc002jcm.1_Silent_p.L143L|GH2_uc002jcn.1_Silent_p.L128L	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	143						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						TGCCTTCCTCTAGGTCCTTCA	0.617													39	71					0	0	0	0	C	61958159	C	C	61958159	2	2	172	1	0	0	0	0	0	0	0	1	6405	1509	53	5		5	GH2	17	61958159	Silent	SNP	T	TCGA-CV-5435-01A-01D-1683-08	1870223	61958159	19237051	115	32434											
CCDC46	201134	broad.mit.edu	37	chr17	63898393	63898393	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actaggctatccttctctgcGttatgctgctgtaataggtg	7	15	10	9	1	1	0	0	0	1	0	3	0	2	0	1	2	3	5	1	2	5	6	rs140758713		TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:63898393G>A	uc002jfl.2	-	20	2259	c.2040C>T	c.(2038-2040)AAC>AAT	p.N680N	CCDC46_uc010deo.2_Silent_p.N422N|CCDC46_uc002jfm.2_Silent_p.N680N|CCDC46_uc010dep.2_Silent_p.N638N	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	680	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			CCTTCTCTGCGTTATGCTGCT	0.463													22	35					0	0	0	0	A	63898393	A	A	63898393	2	1	172	1	0	0	0	0	0	0	0	1	2830	1136	40	1		1	CCDC46	17	63898393	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08	1940234	63898393	17296817	116	32435											
FBF1	85302	broad.mit.edu	37	chr17	73915827	73915827	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcgccgctggtgctgggccGtaagctcagcacgggcctgt	5	7	16	13	4	1	0	1	0	0	0	1	0	1	0	3	3	4	5	3	3	1	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:73915827G>A	uc002jqc.2	-	19	2289	c.2015C>T	c.(2014-2016)ACG>ATG	p.T672M	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.T663M|FBF1_uc002jqd.1_Missense_Mutation_p.T673M|FBF1_uc002jqb.2_RNA|FBF1_uc010dgr.1_Translation_Start_Site	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	672											0						GTGCTGGGCCGTAAGCTCAGC	0.667													3	37					0	0	0	0	A	73915827	A	A	73915827	3	1	172	1	0	0	0	0	1	0	0	0	5727	1145	40	1	1430	1	FBF1	17	73915827	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	10017434	73915827	7279383	117	32436											
TNRC6C	57690	broad.mit.edu	37	chr17	76089205	76089205	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctagcatcaactggcccccaGgtaagaccatgcaacacttc	12	7	7	15	0	1	1	1	0	0	1	2	1	1	1	3	2	4	3	3	2	4	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:76089205G>C	uc002jud.2	+	16	4762	c.4162G>C	c.(4162-4164)GAA>CAA	p.E1388Q	TNRC6C_uc002juf.2_Missense_Mutation_p.E1385Q	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1388	Sufficient for translational repression when tethered to a target mRNA.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CTGGCCCCCAGGTAAGACCAT	0.522													10	13					0	0	0	0	C	76089205	C	C	76089205	3	2	172	1	0	0	0	0	1	0	0	0	16408	1014	35	4	4212	4	TNRC6C	17	76089205	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	2173378	76089205	5106005	118	32437											
RNF213	57674	broad.mit.edu	37	chr17	78351573	78351573	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttcacagcttgtcccaacGgccatccttgctccgtggga	6	11	9	15	2	2	0	1	0	1	0	5	1	5	1	4	2	3	2	4	2	1	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr17:78351573G>A	uc002jyh.1	+	29	7964	c.7741G>A	c.(7741-7743)GGC>AGC	p.G2581S	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.G963S	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TTGTCCCAACGGCCATCCTTG	0.532													68	106					0	0	0	0	A	78351573	A	A	78351573	3	1	172	1	0	0	0	0	1	0	0	0	13542	1116	39	1	14051	1	RNF213	17	78351573	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	2262368	78351573	2843637	119	32438											
FAM59A	64762	broad.mit.edu	37	chr18	29848299	29848299	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gccctggggggtaaggcaggGcatgacgtactctgctttgt	6	10	16	9	1	1	1	0	1	1	0	1	1	1	1	1	5	2	5	1	5	2	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr18:29848299G>A	uc002kxl.2	-	6	2222	c.2166C>T	c.(2164-2166)TGC>TGT	p.C722C	FAM59A_uc002kxk.1_Silent_p.C721C	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	722										ovary(1)|skin(1)	2						GTAAGGCAGGGCATGACGTAC	0.532													13	72					0	0	0	0	A	29848299	A	A	29848299	2	1	172	1	0	0	0	0	0	0	0	1	5624	1195	42	4		4	FAM59A	18	29848299	Silent	SNP	G	TCGA-CV-5435-01A-01D-1683-08		29848299	48228949	120	32439											
CDH7	1005	broad.mit.edu	37	chr18	63547907	63547907	+	Frame_Shift_Del	DEL	G	-	-																															catctttagggaatttatttGggaaagattaaaagaagccg																										TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	d99c24f9-3ac5-49c5-9323-3235c64f37ce	g.chr18:63547907delG	uc002ljz.2	+	12	2460	c.2135delG	c.(2134-2136)TGGfs	p.W712fs	CDH7_uc002lkb.2_Frame_Shift_Del_p.W712fs	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	712	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GAATTTATTTGGGAAAGATTA	0.438													---	---	---								-	63547907	-	-	63547907	7	5	172	1	0	1	0	1	0	0	0	0	3130	1357	47	0	2177	0	CDH7	18	63547907	Frame_Shift_Del	DEL	G	TCGA-CV-5435-01A-01D-1683-08	33699608	63547907	14529341	121	32440											
CILP2	148113	broad.mit.edu	37	chr19	19655287	19655287	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacctacggcatgttctccGtggacctccgtgcgcccggc	4	8	12	17	5	1	0	0	0	1	0	3	1	2	1	5	3	2	3	5	3	1	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr19:19655287G>A	uc002nmv.3	+	8	2018	c.1933G>A	c.(1933-1935)GTG>ATG	p.V645M	CILP2_uc002nmw.3_Missense_Mutation_p.V651M	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	645						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CATGTTCTCCGTGGACCTCCG	0.731													25	43					0	0	0	0	A	19655287	A	A	19655287	3	1	172	1	0	0	0	0	1	0	0	0	3445	1145	40	1	1963	1	CILP2	19	19655287	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08		19655287	39473696	122	32441											
ZNF431	170959	broad.mit.edu	37	chr19	21365730	21365730	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaacctttcaaatgtaaaaaAtgtggcaaatcattttgcat	17	13	5	6	0	2	0	2	0	0	0	2	0	2	0	1	1	2	3	1	1	6	4			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr19:21365730A>G	uc002npp.2	+	5	771	c.624A>G	c.(622-624)AAA>AAG	p.K208K	ZNF431_uc010ecq.2_Silent_p.K117K|ZNF431_uc010ecr.2_Silent_p.K209K	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	208	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						AATGTAAAAAATGTGGCAAAT	0.284													12	32					0	0	0	0	G	21365730	G	G	21365730	2	3	172	1	0	0	0	0	0	0	0	1	17972	98	4	5		5	ZNF431	19	21365730	Silent	SNP	A	TCGA-CV-5435-01A-01D-1683-08	1710443	21365730	37763253	123	32442											
ZNF536	9745	broad.mit.edu	37	chr19	31039034	31039034	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctgttcatcaggccagaCatcctgaggggggccttcaa	8	10	11	12	0	4	2	3	1	1	1	6	2	5	2	3	4	0	1	3	4	1	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr19:31039034C>A	uc002nsu.1	+	4	2646	c.2508C>A	c.(2506-2508)GAC>GAA	p.D836E	ZNF536_uc010edd.1_Missense_Mutation_p.D836E	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	836					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TCAGGCCAGACATCCTGAGGG	0.582													27	57					3.65163e-15	4.4246e-15	1	0	A	31039034	A	A	31039034	3	1	172	1	0	0	0	0	1	0	0	0	18041	477	17	4	2518	4	ZNF536	19	31039034	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	9673304	31039034	28089949	124	32443											
SIGLEC14	100049587	broad.mit.edu	37	chr19	52148741	52148741	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctttcctacctgtgcctgtgCcatttctgaagaagatgctg	7	14	9	11	0	1	3	0	1	1	2	2	3	2	3	4	0	4	1	4	0	3	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr19:52148741C>A	uc002pxf.3	-	4	863	c.743G>T	c.(742-744)GGC>GTC	p.G248V		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	248	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		TGTGCCTGTGCCATTTCTGAA	0.552													14	44					1.5842e-08	1.74157e-08	1	0	A	52148741	A	A	52148741	3	1	172	1	0	0	0	0	1	0	0	0	14374	739	26	4	463	4	SIGLEC14	19	52148741	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	21109707	52148741	6980242	125	32444											
ZNF534	147658	broad.mit.edu	37	chr19	52941671	52941671	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttactgctcatcttgtaatcCatactggagagaaaccttat	12	14	6	9	0	2	1	1	0	1	1	3	3	3	2	2	1	4	2	2	1	5	5			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr19:52941671C>A	uc002pzk.2	+	4	1058	c.997C>A	c.(997-999)CAT>AAT	p.H333N	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.H320N	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	333	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCTTGTAATCCATACTGGAGA	0.418													11	10					0.000978159	0.00101484	1	0	A	52941671	A	A	52941671	3	1	172	1	0	0	0	0	1	0	0	0	18040	594	21	4	1011	4	ZNF534	19	52941671	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	792930	52941671	6187312	126	32445											
PRKCG	5582	broad.mit.edu	37	chr19	54409991	54409991	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcggcgagaactttgacaagTtcttcacgcgggcggcgcca	8	7	14	12	6	2	2	1	1	1	1	2	3	2	2	1	3	1	1	1	3	2	3			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr19:54409991T>C	uc002qcq.1	+	18	2218	c.1936T>C	c.(1936-1938)TTC>CTC	p.F646L	PRKCG_uc010yeg.1_Missense_Mutation_p.F646L|PRKCG_uc010yeh.1_Missense_Mutation_p.F497L	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	646	AGC-kinase C-terminal.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CTTTGACAAGTTCTTCACGCG	0.647											OREG0025667	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	125					0	0	0	0	C	54409991	C	C	54409991	3	2	172	1	0	0	0	0	1	0	0	0	12574	1725	60	5	2006	5	PRKCG	19	54409991	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08	1468320	54409991	4718992	127	32446											
JAG1	182	broad.mit.edu	37	chr20	10639359	10639359	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgagaagccttttcaataaTactgtcaggttctagagaca	13	12	9	7	0	3	2	2	1	1	2	3	4	3	2	1	1	2	1	1	1	5	6			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr20:10639359T>C	uc002wnw.2	-	4	967	c.451A>G	c.(451-453)ATT>GTT	p.I151V		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	151	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						TTTTCAATAATACTGTCAGGT	0.448									Alagille_Syndrome				16	80					0	0	0	0	C	10639359	C	C	10639359	3	2	172	1	0	0	0	0	1	0	0	0	7973	1406	49	5	3297	5	JAG1	20	10639359	Missense_Mutation	SNP	T	TCGA-CV-5435-01A-01D-1683-08		10639359	52386161	128	32447											
ID1	3397	broad.mit.edu	37	chr20	30193543	30193543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggaatccgaagttggaacccCcgggggccgagggctgccgg	7	4	18	12	4	0	0	0	0	0	0	1	4	1	2	5	6	2	2	5	6	3	1			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr20:30193543C>T	uc002wwg.1	+	1	452	c.353C>T	c.(352-354)CCC>CTC	p.P118L	ID1_uc002wwh.1_Missense_Mutation_p.P118L|hsa-mir-3193|MI0014238_5'Flank	NM_002165	NP_002156	P41134	ID1_HUMAN	inhibitor of DNA binding 1 isoform a	118					angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			ovary(1)	1	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			GTTGGAACCCCCGGGGGCCGA	0.622													4	17					0	0	0	0	T	30193543	T	T	30193543	3	4	172	1	0	0	0	0	1	0	0	0	7528	623	22	4	355	4	ID1	20	30193543	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	19554184	30193543	32831977	129	32448											
HLCS	3141	broad.mit.edu	37	chr21	38308946	38308946	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaaaaccaagttctggaCtgtcttgtgcagtgcaccct	10	10	11	10	0	2	1	0	0	2	1	2	3	2	2	2	2	3	3	2	2	3	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr21:38308946C>T	uc010gnb.2	-	4	2000	c.799G>A	c.(799-801)GTC>ATC	p.V267I	HLCS_uc002yvs.2_Missense_Mutation_p.V267I|HLCS_uc010gnc.1_Missense_Mutation_p.V414I	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	267					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	AAGTTCTGGACTGTCTTGTGC	0.572													18	44					0	0	0	0	T	38308946	T	T	38308946	3	4	172	1	0	0	0	0	1	0	0	0	7252	565	20	4	1413	4	HLCS	21	38308946	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08		38308946	9820949	130	32449											
CRYBB3	1417	broad.mit.edu	37	chr22	25598707	25598707	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcggccgagtgccccagcCtgaccgacagcctgctggag	6	6	13	16	3	1	1	0	1	1	0	2	4	1	2	6	2	4	1	6	2	0	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr22:25598707C>A	uc003abo.1	+	3	214	c.142C>A	c.(142-144)CTG>ATG	p.L48M		NM_004076	NP_004067	P26998	CRBB3_HUMAN	crystallin, beta B3	48	Beta/gamma crystallin 'Greek key' 1.				visual perception		protein binding|structural constituent of eye lens				0						GTGCCCCAGCCTGACCGACAG	0.587											OREG0026423	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	34					9.62636e-23	1.19252e-22	1	0	A	25598707	A	A	25598707	3	1	172	1	0	0	0	0	1	0	0	0	3927	680	24	4	148	4	CRYBB3	22	25598707	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08		25598707	25705859	131	32450											
SSTR3	6753	broad.mit.edu	37	chr22	37603421	37603421	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgtaccacggccaggtagCggtccacgctcatgacagtc	9	7	12	13	3	1	1	1	1	0	0	3	2	2	1	3	3	2	3	3	3	2	2			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr22:37603421C>T	uc003ara.2	-	2	484	c.422G>A	c.(421-423)CGC>CAC	p.R141H	SSTR3_uc003arb.2_Missense_Mutation_p.R141H	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	141	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						GGCCAGGTAGCGGTCCACGCT	0.667													61	71					0	0	0	0	T	37603421	T	T	37603421	3	4	172	1	0	0	0	0	1	0	0	0	15265	768	27	1	838	1	SSTR3	22	37603421	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	12004714	37603421	13701145	132	32451											
KLHDC7B	113730	broad.mit.edu	37	chr22	50987418	50987418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgagcgcatcctcagcctgCggaccggccggggccgggcg	4	3	18	16	7	1	0	1	0	0	0	2	2	2	1	5	5	3	1	5	5	0	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chr22:50987418C>T	uc003bmi.2	+	1	957	c.823C>T	c.(823-825)CGG>TGG	p.R275W		NM_138433	NP_612442	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	275										central_nervous_system(1)	1		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCTCAGCCTGCGGACCGGCCG	0.746													10	5					0	0	0	0	T	50987418	T	T	50987418	3	4	172	1	0	0	0	0	1	0	0	0	8400	759	27	1	825	1	KLHDC7B	22	50987418	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08	13383997	50987418	317148	133	32452											
HEPH	9843	broad.mit.edu	37	chrX	65393539	65393539	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccagaaggccatgcacccaCcgatgctgacccagcgtgcc	9	5	10	17	2	0	2	0	1	0	1	1	3	1	2	6	1	4	2	6	1	1	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	d99c24f9-3ac5-49c5-9323-3235c64f37ce	g.chrX:65393539C>T	uc011moz.1	+	4	590	c.530C>T	c.(529-531)ACC>ATC	p.T177I	HEPH_uc004dwn.2_Missense_Mutation_p.T177I|HEPH_uc004dwo.2_5'UTR|HEPH_uc010nkr.2_Missense_Mutation_p.T177I|HEPH_uc011mpa.1_Missense_Mutation_p.T177I	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	174	Extracellular (Potential).|Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						CATGCACCCACCGATGCTGAC	0.552													5	9					0	0	0	0	T	65393539	T	T	65393539	3	4	172	1	0	0	0	0	1	0	0	0	7093	507	18	4	697	4	HEPH	23	65393539	Missense_Mutation	SNP	C	TCGA-CV-5435-01A-01D-1683-08		65393539	89877021	134	32453											
ESX1	80712	broad.mit.edu	37	chrX	103495254	103495254	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggccagggtggcacaggCgccatgcgtggcccgggtgg	4	4	21	12	4	0	0	0	0	0	0	0	0	0	0	3	8	1	1	3	8	0	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chrX:103495254C>T	uc004ely.2	-	4	934	c.876G>A	c.(874-876)GCG>GCA	p.A292A		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	292	6.|15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTGGCACAGGCGCCATGCGTG	0.612													12	15					0	0	0	0	T	103495254	T	T	103495254	2	4	172	1	0	0	0	0	0	0	0	1	5287	755	27	1		1	ESX1	23	103495254	Silent	SNP	C	TCGA-CV-5435-01A-01D-1683-08	38101715	103495254	51775306	135	32454											
MAGEA6	4105	broad.mit.edu	37	chrX	151869581	151869581	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaggactccagcaaccaaGaagaggaggggccaagcacc	15	2	13	11	0	0	3	0	1	0	2	1	5	1	5	4	4	3	2	4	4	4	0			TCGA-CV-5435-01A-01D-1683-08	TCGA-CV-5435-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec0a719b-3c3a-4797-9ec5-90d3474da727	fe078b43-0f76-4648-ac30-af1599fd3421	g.chrX:151869581G>A	uc004ffq.1	+	3	465	c.271G>A	c.(271-273)GAA>AAA	p.E91K	MAGEA6_uc004ffr.1_Missense_Mutation_p.E91K|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	91							protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCAACCAAGAAGAGGAGGG	0.557													14	27					0	0	0	0	A	151869581	A	A	151869581	3	1	172	1	0	0	0	0	1	0	0	0	9221	943	33	2	273	2	MAGEA6	23	151869581	Missense_Mutation	SNP	G	TCGA-CV-5435-01A-01D-1683-08	48374327	151869581	3400979	136	32455											
PAX7	5081	broad.mit.edu	37	chr1	18962744	18962744	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctgaggtttagtgagttcGattagccgcgtgctcagaat	8	14	12	7	3	2	3	1	2	1	1	3	4	2	3	1	1	2	3	1	1	3	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:18962744G>A	uc001bay.2	+	4	1063	c.465G>A	c.(463-465)TCG>TCA	p.S155S	PAX7_uc001baz.2_Silent_p.S153S|PAX7_uc010oct.1_Silent_p.S155S	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	155	Paired.				anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		TAGTGAGTTCGATTAGCCGCG	0.363			T	FOXO1A	alveolar rhabdomyosarcoma								47	100					0	0	0	0	A	18962744	A	A	18962744	2	1	173	1	0	0	0	0	0	0	0	1	11538	1045	37	1		1	PAX7	1	18962744	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08		18962744	230287877	1	32456											
EPHA10	284656	broad.mit.edu	37	chr1	38181550	38181550	+	RNA	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatgcagagagatctcagacGcagattctggacacccctgt	11	9	10	11	1	2	4	1	0	2	4	3	6	2	5	2	1	1	2	2	1	1	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:38181550G>A	uc001cbt.2	-	7		c.938C>T			EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA			Q5JZY3	EPHAA_HUMAN	Homo sapiens cDNA FLJ16103 fis, clone TESTI2016663, moderately similar to EPHRIN TYPE-A RECEPTOR 7 PRECURSOR (EC 2.7.1.112).							extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GATCTCAGACGCAGATTCTGG	0.557													18	43					0	0	0	0	A	38181550	A	A	38181550	1	1	173	0	1	0	0	0	0	0	0	0	5190	1102	38	1		1	EPHA10	1	38181550	RNA	SNP	G	TCGA-CV-5436-01A-01D-1512-08	19218806	38181550	211069071	2	32457											
KIAA0467	23334	broad.mit.edu	37	chr1	43885835	43885835	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcttccaggctctcagcacCgcctatttaatgagcacctg	8	11	8	14	1	2	1	1	1	2	0	4	1	3	1	4	1	2	3	4	1	2	4			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:43885835C>T	uc001cjk.1	+						KIAA0467_uc009vws.1_Missense_Mutation_p.R368C	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334							peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCTCAGCACCGCCTATTTAA	0.562													4	72					0	0	0	0	T	43885835	T	T	43885835	1	4	173	0	1	0	0	0	0	0	0	0	8217	667	23	1		1	KIAA0467	1	43885835	5'Flank	SNP	C	TCGA-CV-5436-01A-01D-1512-08	5704285	43885835	205364786	3	32458											
KIAA0467	23334	broad.mit.edu	37	chr1	43907942	43907942	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctcccccaccctgtagctgCcaaagccatgcagcgcttcg	7	7	8	19	2	0	0	0	0	0	0	2	0	1	0	6	0	5	4	6	0	2	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:43907942C>G	uc001cjk.1	+	42	5642	c.5180C>G	c.(5179-5181)GCC>GGC	p.A1727G		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2626						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTGTAGCTGCCAAAGCCATG	0.602													12	35					0	0	0	0	G	43907942	G	G	43907942	3	3	173	1	0	0	0	0	1	0	0	0	8217	739	26	4	5338	4	KIAA0467	1	43907942	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	22107	43907942	205342679	4	32459											
EPS8L3	79574	broad.mit.edu	37	chr1	110294291	110294291	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agtacccgagagggtgactgGccctgggtcccaggggtccc	6	6	16	13	1	0	2	0	1	0	1	2	3	2	2	4	5	1	1	4	5	1	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:110294291G>A	uc001dyr.1	-	16	1693	c.1548C>T	c.(1546-1548)GGC>GGT	p.G516G	EPS8L3_uc001dys.1_Silent_p.G486G|EPS8L3_uc001dyq.1_Silent_p.G517G|EPS8L3_uc009wfm.1_Silent_p.G453G|EPS8L3_uc009wfn.1_Silent_p.G461G	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	516						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		AGGGTGACTGGCCCTGGGTCC	0.622													33	44					0	0	0	0	A	110294291	A	A	110294291	2	1	173	1	0	0	0	0	0	0	0	1	5221	1190	42	4		4	EPS8L3	1	110294291	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	66386349	110294291	138956330	5	32460											
FLG	2312	broad.mit.edu	37	chr1	152277201	152277201	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatgagtgctcacctggtaGaggaaagaccctgaacgtcc	11	8	11	11	1	2	4	2	2	0	2	3	5	3	5	3	2	2	2	3	2	3	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:152277201G>A	uc001ezu.1	-	3	10197	c.10161C>T	c.(10159-10161)CTC>CTT	p.L3387L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3387	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCACCTGGTAGAGGAAAGACC	0.612									Ichthyosis				201	385					0	0	0	0	A	152277201	A	A	152277201	2	1	173	1	0	0	0	0	0	0	0	1	5954	929	33	2		2	FLG	1	152277201	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	41982910	152277201	96973420	6	32461											
DENND4B	9909	broad.mit.edu	37	chr1	153905961	153905961	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctccttcactggctacctCggaggcagtggatccagggc	6	8	12	15	1	1	0	1	0	0	0	4	2	3	2	4	5	1	2	4	5	1	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:153905961C>T	uc001fdd.1	-	20	3729	c.3328G>A	c.(3328-3330)GAG>AAG	p.E1110K	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1110	Ser-rich.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGGCTACCTCGGAGGCAGTG	0.647													10	19					0	0	0	0	T	153905961	T	T	153905961	3	4	173	1	0	0	0	0	1	0	0	0	4456	893	31	1	1198	1	DENND4B	1	153905961	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	1628760	153905961	95344660	7	32462											
DENND4B	9909	broad.mit.edu	37	chr1	153906274	153906274	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctcctcccctgtcaggctCaggtctgagagacttccatc	6	10	10	15	0	3	2	2	1	1	1	7	3	6	2	4	3	0	2	4	3	0	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:153906274C>G	uc001fdd.1	-	20	3416	c.3015G>C	c.(3013-3015)CTG>CTC	p.L1005L	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1005										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGTCAGGCTCAGGTCTGAGA	0.642													13	14					0	0	0	0	G	153906274	G	G	153906274	2	3	173	1	0	0	0	0	0	0	0	1	4456	813	29	2		2	DENND4B	1	153906274	Silent	SNP	C	TCGA-CV-5436-01A-01D-1512-08	313	153906274	95344347	8	32463											
C1orf125	126859	broad.mit.edu	37	chr1	179414261	179414261	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agggggagatgccatcagagCgacagtacatggaggaaatt	14	6	15	6	1	1	2	1	0	0	2	1	6	1	4	1	4	3	1	1	4	2	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:179414261C>G	uc001gmo.2	+	16	1847	c.1720C>G	c.(1720-1722)CGA>GGA	p.R574G	C1orf125_uc009wxg.2_Intron|C1orf125_uc001gmn.1_Missense_Mutation_p.R362G|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.R574G	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	574	Potential.										0						GCCATCAGAGCGACAGTACAT	0.338													35	67					0	0	0	0	G	179414261	G	G	179414261	3	3	173	1	0	0	0	0	1	0	0	0	2002	760	27	3	1778	3	C1orf125	1	179414261	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	25507987	179414261	69836360	9	32464											
QSOX1	5768	broad.mit.edu	37	chr1	180155269	180155269	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcaggttcccggtcctggaAgggcagcgcctggtggccct	4	7	17	13	2	0	0	0	0	0	0	2	1	2	1	4	7	1	3	4	7	1	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:180155269A>G	uc001gnz.2	+	8	1044	c.969A>G	c.(967-969)GAA>GAG	p.E323E	QSOX1_uc001gny.2_Silent_p.E323E|QSOX1_uc001goa.2_Silent_p.E323E	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	323					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						CGGTCCTGGAAGGGCAGCGCC	0.577													20	53					0	0	0	0	G	180155269	G	G	180155269	2	3	173	1	0	0	0	0	0	0	0	1	12948	69	3	5		5	QSOX1	1	180155269	Silent	SNP	A	TCGA-CV-5436-01A-01D-1512-08	741008	180155269	69095352	10	32465											
RNPEP	6051	broad.mit.edu	37	chr1	201965306	201965306	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggctgagccctgcctgattGatgctgccaaggaggagtac	8	8	15	10	0	0	3	0	3	0	0	0	5	0	5	3	3	5	3	3	3	2	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:201965306G>C	uc001gxd.2	+	4	798	c.769G>C	c.(769-771)GAT>CAT	p.D257H	RNPEP_uc001gxe.2_5'UTR|RNPEP_uc001gxf.2_Missense_Mutation_p.D126H	NM_020216	NP_064601	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase	257					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		CTGCCTGATTGATGCTGCCAA	0.493													57	108					0	0	0	0	C	201965306	C	C	201965306	3	2	173	1	0	0	0	0	1	0	0	0	13574	1290	45	2	783	2	RNPEP	1	201965306	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	21810037	201965306	47285315	11	32466											
KCTD3	51133	broad.mit.edu	37	chr1	215777507	215777507	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctggatcgagatcgcctatgGtacgagctctggagcagtac	9	9	13	10	3	1	1	0	0	1	1	3	5	1	3	1	3	4	4	1	3	3	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:215777507G>A	uc001hks.2	+	13	1466	c.1172G>A	c.(1171-1173)GGT>GAT	p.G391D	KCTD3_uc001hkt.2_Missense_Mutation_p.G391D|KCTD3_uc010pub.1_Missense_Mutation_p.G289D|KCTD3_uc009xdn.2_Missense_Mutation_p.G143D	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	391						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		ATCGCCTATGGTACGAGCTCT	0.453													33	86					0	0	0	0	A	215777507	A	A	215777507	3	1	173	1	0	0	0	0	1	0	0	0	8149	1261	44	4	1222	4	KCTD3	1	215777507	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	13812201	215777507	33473114	12	32467											
HHIPL2	79802	broad.mit.edu	37	chr1	222717416	222717416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtcagcagggaaatggctGagtgacagttagaatggaag	13	8	16	4	0	1	3	1	2	0	1	1	5	1	5	0	4	1	3	0	4	4	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr1:222717416G>A	uc001hnh.1	-	2	495	c.437C>T	c.(436-438)TCA>TTA	p.S146L		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	146					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GGAAATGGCTGAGTGACAGTT	0.587													70	142					0	0	0	0	A	222717416	A	A	222717416	3	1	173	1	0	0	0	0	1	0	0	0	7133	1294	45	2	1769	2	HHIPL2	1	222717416	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	6939909	222717416	26533205	13	32468											
APOB	338	broad.mit.edu	37	chr2	21233522	21233522	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attcttgcaaggtctcaaaaAatgggaggttaatggagtga	14	11	12	4	0	2	1	1	1	2	0	3	3	2	3	0	4	1	2	0	4	5	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:21233522A>G	uc002red.2	-	26	6346	c.6218T>C	c.(6217-6219)TTT>TCT	p.F2073S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2073	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGTCTCAAAAAATGGGAGGTT	0.358													59	102					0	0	0	0	G	21233522	G	G	21233522	3	3	173	1	0	0	0	0	1	0	0	0	785	14	1	5	7489	5	APOB	2	21233522	Missense_Mutation	SNP	A	TCGA-CV-5436-01A-01D-1512-08		21233522	221965851	14	32469											
ADCY3	109	broad.mit.edu	37	chr2	25061315	25061315	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtggggtggggaactcaccGagccattgaggccattctgg	7	8	17	9	1	2	1	1	1	1	0	2	3	2	2	3	7	2	0	3	7	1	2	rs139407103	byFrequency	TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:25061315G>A	uc002rfs.3	-	7	1731	c.1532C>T	c.(1531-1533)TCG>TTG	p.S511L	ADCY3_uc002rfr.3_Missense_Mutation_p.S144L|ADCY3_uc010ykm.1_Missense_Mutation_p.S511L	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	511	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					ggAACTCACCGAGCCATTGAG	0.398													12	67					0	0	0	0	A	25061315	A	A	25061315	3	1	173	1	0	0	0	0	1	0	0	0	295	1072	37	1	1962	1	ADCY3	2	25061315	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	3827793	25061315	218138058	15	32470											
MEIS1	4211	broad.mit.edu	37	chr2	66739354	66739354	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgataaggacaaaaagcgTcacaaaaagcgtggcatctt	16	7	9	9	2	2	1	1	1	1	0	2	2	2	2	1	2	2	1	1	2	5	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:66739354T>C	uc002sdu.2	+	8	1273	c.816T>C	c.(814-816)CGT>CGC	p.R272R	MEIS1_uc002sdt.2_Silent_p.R272R|MEIS1_uc002sdv.2_Silent_p.R270R|MEIS1_uc010yqh.1_Intron|MEIS1_uc010yqi.1_Silent_p.R207R|MEIS1_uc002sdw.1_Silent_p.R128R	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	272	Homeobox; TALE-type.						sequence-specific DNA binding transcription factor activity				0						ACAAAAAGCGTCACAAAAAGC	0.438													16	14					0	0	0	0	C	66739354	C	C	66739354	2	2	173	1	0	0	0	0	0	0	0	1	9520	1654	58	5		5	MEIS1	2	66739354	Silent	SNP	T	TCGA-CV-5436-01A-01D-1512-08	41678039	66739354	176460019	16	32471											
MAL	4118	broad.mit.edu	37	chr2	95713749	95713749	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggtggcctcctccctggtgCcctggcccctggtccagggc	1	9	14	17	0	0	0	0	0	0	0	3	0	3	0	7	6	1	0	7	6	0	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:95713749C>T	uc002stx.1	+	2	198	c.139C>T	c.(139-141)CCC>TCC	p.P47S	MAL_uc002sty.1_Intron|MAL_uc002stz.1_Missense_Mutation_p.P47S|MAL_uc002sua.1_Intron	NM_002371	NP_002362	P21145	MAL_HUMAN	T-lymphocyte maturation-associated protein	47	MARVEL.|Extracellular (Potential).				apical protein localization|cell differentiation|central nervous system development|induction of apoptosis|membrane raft polarization|myelination	apical plasma membrane|endoplasmic reticulum|endosome|integral to plasma membrane|membrane raft	apoptotic protease activator activity|channel activity|lipid binding|structural constituent of myelin sheath				0				STAD - Stomach adenocarcinoma(1183;0.18)		CTCCCTGGTGCCCTGGCCCCT	0.632													37	82					0	0	0	0	T	95713749	T	T	95713749	3	4	173	1	0	0	0	0	1	0	0	0	9252	739	26	4	145	4	MAL	2	95713749	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	28974395	95713749	147485624	17	32472											
ZAP70	7535	broad.mit.edu	37	chr2	98355850	98355850	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccacaggtgggaggatcgCcccgacttcctgaccgtgga	7	6	13	15	3	0	1	0	1	0	0	2	5	1	4	6	4	0	0	6	4	0	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:98355850C>A	uc002syd.1	+	14	1956	c.1749C>A	c.(1747-1749)CGC>CGA	p.R583R	ZAP70_uc002sye.1_Silent_p.R473R|ZAP70_uc002syf.1_Silent_p.R276R	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	583	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						GGGAGGATCGCCCCGACTTCC	0.657													22	41					3.62473e-10	3.9583e-10	1	0	A	98355850	A	A	98355850	2	1	173	1	0	0	0	0	0	0	0	1	17582	726	26	4		4	ZAP70	2	98355850	Silent	SNP	C	TCGA-CV-5436-01A-01D-1512-08	2642101	98355850	144843523	18	32473											
NMI	9111	broad.mit.edu	37	chr2	152135384	152135384	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgcttgtcctttttgtaTctcataaggaactttcgagc	9	16	8	8	1	1	0	1	0	1	0	4	2	2	1	1	1	3	2	1	1	4	6			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:152135384T>C	uc002txi.2	-	4	628	c.298A>G	c.(298-300)ATA>GTA	p.I100V	NMI_uc010zbx.1_Missense_Mutation_p.I100V|NMI_uc002txj.2_Missense_Mutation_p.I68V	NM_004688	NP_004679	Q13287	NMI_HUMAN	N-myc and STAT interactor	100					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity				0				BRCA - Breast invasive adenocarcinoma(221;0.0571)		CCTTTTTGTATCTCATAAGGA	0.338													19	51					0	0	0	0	C	152135384	C	C	152135384	3	2	173	1	0	0	0	0	1	0	0	0	10551	1435	50	5	645	5	NMI	2	152135384	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	53779534	152135384	91063989	19	32474											
TTN	7273	broad.mit.edu	37	chr2	179501212	179501212	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accagcatcggaaagttgaaCatcaatgatgtgcagctttc	13	10	9	9	1	1	2	1	2	0	0	3	3	1	3	1	1	4	4	1	1	3	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:179501212C>G	uc010zfg.1	-	174	33762	c.33538G>C	c.(33538-33540)GTT>CTT	p.V11180L	TTN_uc010zfh.1_Missense_Mutation_p.V4875L|TTN_uc010zfi.1_Missense_Mutation_p.V4808L|TTN_uc010zfj.1_Missense_Mutation_p.V4683L|TTN_uc010fre.1_Missense_Mutation_p.V1041L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12107							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAAGTTGAACATCAATGATG	0.418													30	161					0	0	0	0	G	179501212	G	G	179501212	3	3	173	1	0	0	0	0	1	0	0	0	16803	478	17	4	67003	4	TTN	2	179501212	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	27365828	179501212	63698161	20	32475											
TTN	7273	broad.mit.edu	37	chr2	179597359	179597359	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatctgattgtgagaggagTagatccttggaaagtgctct	10	12	12	7	0	2	3	0	2	2	2	3	6	3	5	2	2	1	2	2	2	2	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:179597359T>C	uc010zfg.1	-	53	12921	c.12697A>G	c.(12697-12699)ACT>GCT	p.T4233A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T894A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5160							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGAGAGGAGTAGATCCTTGG	0.468													23	67					0	0	0	0	C	179597359	C	C	179597359	3	2	173	1	0	0	0	0	1	0	0	0	16803	1638	57	5	88328	5	TTN	2	179597359	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	96147	179597359	63602014	21	32476											
WDR12	55759	broad.mit.edu	37	chr2	203745631	203745631	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaatatctgtaggaatacaaTttattgtctgctcctccact	11	15	6	9	0	2	0	0	0	2	0	4	2	4	1	2	1	2	2	2	1	7	6			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:203745631T>C	uc002uzl.2	-	13	1974	c.1224A>G	c.(1222-1224)AAA>AAG	p.K408K	WDR12_uc010ftt.2_3'UTR	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	408	Sufficient for nucleolar localization.|WD 7.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						AGGAATACAATTTATTGTCTG	0.323													28	23					0	0	0	0	C	203745631	C	C	203745631	2	2	173	1	0	0	0	0	0	0	0	1	17342	1490	52	5		5	WDR12	2	203745631	Silent	SNP	T	TCGA-CV-5436-01A-01D-1512-08	24148272	203745631	39453742	22	32477											
DOCK10	55619	broad.mit.edu	37	chr2	225662626	225662626	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgacttggaaaaagagcaTgtaggtatcaaagacccttt	15	11	9	6	0	1	3	1	1	0	2	1	4	1	4	1	2	1	3	1	2	5	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:225662626T>A	uc010fwz.1	-	42	4806	c.4567A>T	c.(4567-4569)ATG>TTG	p.M1523L	DOCK10_uc002vob.2_Missense_Mutation_p.M1517L|DOCK10_uc002voa.2_Missense_Mutation_p.M179L|DOCK10_uc002voc.2_Missense_Mutation_p.M377L	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1523							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AAAAAGAGCATGTAGGTATCA	0.408													51	58					0	0	0	0	A	225662626	A	A	225662626	3	1	173	1	0	0	0	0	1	0	0	0	4707	1464	51	5	2053	5	DOCK10	2	225662626	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	21916995	225662626	17536747	23	32478											
SH3BP4	23677	broad.mit.edu	37	chr2	235951774	235951774	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgccgctcacctttttctgCcgggcagagctggatagtga	6	11	12	12	2	2	2	1	1	1	1	2	3	2	3	3	2	3	3	3	2	1	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr2:235951774C>A	uc002vvp.2	+	4	2754	c.2361C>A	c.(2359-2361)TGC>TGA	p.C787*	SH3BP4_uc010fym.2_Nonsense_Mutation_p.C787*|SH3BP4_uc002vvq.2_Nonsense_Mutation_p.C787*	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	787					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CCTTTTTCTGCCGGGCAGAGC	0.582													13	15					1.67942e-08	1.81173e-08	1	0	A	235951774	A	A	235951774	4	1	173	1	0	0	0	0	0	1	0	0	14311	747	26	4	2367	4	SH3BP4	2	235951774	Nonsense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	10289148	235951774	7247599	24	32479											
HACL1	26061	broad.mit.edu	37	chr3	15616518	15616518	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catctggctgatatcttggaGgcagtccaaaatgtaaaatc	13	11	9	8	0	2	1	0	1	2	0	4	2	3	2	1	3	0	3	1	3	5	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr3:15616518G>A	uc003caf.2	-	10	1035	c.875C>T	c.(874-876)CCT>CTT	p.P292L	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Missense_Mutation_p.P265L|HACL1_uc011avt.1_Missense_Mutation_p.P266L|HACL1_uc003cag.2_Intron|HACL1_uc011avu.1_Missense_Mutation_p.P210L|HACL1_uc010hep.2_Intron	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	292					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						ATATCTTGGAGGCAGTCCAAA	0.343													18	18					0	0	0	0	A	15616518	A	A	15616518	3	1	173	1	0	0	0	0	1	0	0	0	6980	1000	35	4	893	4	HACL1	3	15616518	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08		15616518	182405912	25	32480											
POLQ	10721	broad.mit.edu	37	chr3	121207907	121207907	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtacctgttttttcttgtaGtctagaaatatttagaaaat	13	18	6	4	0	2	2	0	0	2	2	2	2	2	2	1	0	1	3	1	0	8	10			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr3:121207907G>C	uc003eee.3	-	16	4000	c.3871C>G	c.(3871-3873)CTA>GTA	p.L1291V	POLQ_uc003eed.2_Missense_Mutation_p.L463V	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1291					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TTTTCTTGTAGTCTAGAAATA	0.333								DNA_polymerases_(catalytic_subunits)					64	200					0	0	0	0	C	121207907	C	C	121207907	3	2	173	1	0	0	0	0	1	0	0	0	12263	1020	36	4	3961	4	POLQ	3	121207907	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	105591389	121207907	76814523	26	32481											
SEMA5B	54437	broad.mit.edu	37	chr3	122645415	122645415	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacgtcattcttgcacacGcgggccacgcgagagtacac	9	6	10	16	5	2	1	1	0	1	1	2	2	2	1	2	1	2	2	2	1	1	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr3:122645415G>A	uc003efz.1	-	9	1264	c.960C>T	c.(958-960)CGC>CGT	p.R320R	SEMA5B_uc011bju.1_Silent_p.R262R|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.R320R|SEMA5B_uc010hro.1_Silent_p.R262R|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	320	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TCTTGCACACGCGGGCCACGC	0.617													19	58					0	0	0	0	A	122645415	A	A	122645415	2	1	173	1	0	0	0	0	0	0	0	1	14103	1074	38	1		1	SEMA5B	3	122645415	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	1437508	122645415	75377015	27	32482											
PIK3R4	30849	broad.mit.edu	37	chr3	130454754	130454754	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcaattttatttagcacttGttcagggaaaaaatgtccat	13	16	6	6	0	2	0	2	0	0	0	3	1	3	1	1	1	1	2	1	1	6	7			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr3:130454754G>C	uc003enj.2	-	3	1407	c.826C>G	c.(826-828)CAA>GAA	p.Q276E		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	276	Protein kinase.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TTTAGCACTTGTTCAGGGAAA	0.333													44	182					0	0	0	0	C	130454754	C	C	130454754	3	2	173	1	0	0	0	0	1	0	0	0	11976	1386	48	4	3322	4	PIK3R4	3	130454754	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	7809339	130454754	67567676	28	32483											
MED12L	116931	broad.mit.edu	37	chr3	150903227	150903227	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcaaaactcctggagaagagGcaagcagaaattgaggcaga	17	4	13	7	0	0	5	0	1	0	4	1	6	1	5	1	3	2	4	1	3	5	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr3:150903227G>A	uc003eyp.2	+	11	1643	c.1605G>A	c.(1603-1605)AGG>AGA	p.R535R	MED12L_uc011bnz.1_Silent_p.R395R|MED12L_uc003eyn.2_Silent_p.R535R|MED12L_uc003eyo.2_Silent_p.R535R	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	535					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGGAGAAGAGGCAAGCAGAAA	0.478													20	51					0	0	0	0	A	150903227	A	A	150903227	2	1	173	1	0	0	0	0	0	0	0	1	9482	1194	42	4		4	MED12L	3	150903227	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	20448473	150903227	47119203	29	32484											
RTP4	64108	broad.mit.edu	37	chr3	187089105	187089106	+	Frame_Shift_Del	DEL	TG	-	-																															acccagatccactgaacatcTgtgtctttattttgctgctt																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr3:187089105_187089106delTG	uc003frm.2	+	2	747_748	c.685_686delTG	c.(685-687)TGTfs	p.C229fs		NM_022147	NP_071430	Q96DX8	RTP4_HUMAN	28kD interferon responsive protein	229	Helical; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding				0	all_cancers(143;4.66e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		ACTGAACATCTGTGTCTTTATT	0.421													---	---	---								-	187089106	-	-	187089105	7	5	173	1	0	1	0	1	0	0	0	0	13801	1580	55	0	691	0	RTP4	3	187089105	Frame_Shift_Del	DEL	TG	TCGA-CV-5436-01A-01D-1512-08	36185878	187089105	10933325	30	32485											
DRD5	1816	broad.mit.edu	37	chr4	9784853	9784853	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atctcctacaaccaagacatCgtcttccacaaggaaatcgc	14	8	5	14	2	2	1	0	0	2	1	6	2	3	2	3	1	2	0	3	1	5	2	rs114936842	by1000genomes	TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr4:9784853C>G	uc003gmb.3	+	1	1596	c.1200C>G	c.(1198-1200)ATC>ATG	p.I400M		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	400	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	ACCAAGACATCGTCTTCCACA	0.592													3	66					0	0	0	0	G	9784853	G	G	9784853	3	3	173	1	0	0	0	0	1	0	0	0	4782	874	31	3	1202	3	DRD5	4	9784853	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08		9784853	181369423	31	32486											
ZCCHC4	29063	broad.mit.edu	37	chr4	25314313	25314314	+	5'Flank	INS	-	G	G																															gcgtggcctccgccgcggcaINSgcccccgcccaagctcctcc																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr4:25314313_25314314insG	uc003grl.3	+							NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4								methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				CCGCCGCGGCAGCCCCCGCCCA	0.698											OREG0016141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								G	25314314	G	G	25314313	6	5	173	0	1	1	1	0	0	0	0	0	17657	203	7	0		0	ZCCHC4	4	25314313	5'Flank	INS	-	TCGA-CV-5436-01A-01D-1512-08	15529460	25314313	165839963	32	32487											
SMR3A	26952	broad.mit.edu	37	chr4	71227862	71227862	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgacttggatcttgggcctTtgggctcttgcagcgtgttt	3	16	13	9	1	2	1	0	1	2	0	2	2	2	2	1	3	2	3	1	3	0	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr4:71227862T>G	uc003hfg.1	+	2	111	c.30T>G	c.(28-30)CTT>CTG	p.L10L	SMR3B_uc011cas.1_Silent_p.L10L	NM_012390	NP_036522	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3	10						extracellular region					0		all_hematologic(202;0.196)				TCTTGGGCCTTTGGGCTCTTG	0.338													60	187					0	0	0	0	G	71227862	G	G	71227862	2	3	173	1	0	0	0	0	0	0	0	1	14875	1828	64	5		5	SMR3A	4	71227862	Silent	SNP	T	TCGA-CV-5436-01A-01D-1512-08	45913549	71227862	119926414	33	32488											
CXCL6	6372	broad.mit.edu	37	chr4	74702557	74702557	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgctcctgctgacgccGccggggcccctcgccagcgg	2	6	14	19	5	0	1	0	1	0	0	2	1	1	1	6	3	4	3	6	3	0	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr4:74702557G>A	uc003hhf.2	+	1	285	c.90G>A	c.(88-90)CCG>CCA	p.P30P	IL8_uc011cbh.1_Intron	NM_002993	NP_002984	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6 (granulocyte	30					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			TGCTGACGCCGCCGGGGCCCC	0.716													3	56					0	0	0	0	A	74702557	A	A	74702557	2	1	173	1	0	0	0	0	0	0	0	1	4105	1074	38	1		1	CXCL6	4	74702557	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	3474695	74702557	116451719	34	32489											
C4orf37	285555	broad.mit.edu	37	chr4	98480263	98480263	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttcctttctttttctcctgGgatatctgtttaataagaat	8	21	5	7	0	3	1	0	0	3	1	5	2	4	2	2	1	0	1	2	1	4	8			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr4:98480263G>T	uc003htt.1	-	11	1416	c.1326C>A	c.(1324-1326)TCC>TCA	p.S442S		NM_174952	NP_777612	Q8N412	CD037_HUMAN	hypothetical protein LOC285555	442											0				OV - Ovarian serous cystadenocarcinoma(123;2.27e-08)		TTTTCTCCTGGGATATCTGTT	0.279													64	75					3.8688e-20	4.4144e-20	1	0	T	98480263	T	T	98480263	2	4	173	1	0	0	0	0	0	0	0	1	2277	1219	43	4		4	C4orf37	4	98480263	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	23777706	98480263	92674013	35	32490											
KIAA1109	84162	broad.mit.edu	37	chr4	123140523	123140523	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttggggaagatgacatgtAtatggattttgaagaggtta	12	14	13	2	0	0	4	0	2	0	2	0	6	0	6	0	4	0	2	0	4	5	6			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr4:123140523A>G	uc003ieh.2	+	19	2321	c.2276A>G	c.(2275-2277)TAT>TGT	p.Y759C	KIAA1109_uc003iei.1_Missense_Mutation_p.Y513C|KIAA1109_uc010ins.1_Missense_Mutation_p.Y103C|KIAA1109_uc003iej.1_Missense_Mutation_p.Y144C	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	759					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GATGACATGTATATGGATTTT	0.353													73	209					0	0	0	0	G	123140523	G	G	123140523	3	3	173	1	0	0	0	0	1	0	0	0	8247	449	16	5	2350	5	KIAA1109	4	123140523	Missense_Mutation	SNP	A	TCGA-CV-5436-01A-01D-1512-08	24660260	123140523	68013753	36	32491											
TMEM154	201799	broad.mit.edu	37	chr4	153601078	153601078	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agactagggctgcgcggggaGcctgcatgtccgctcgcctc	5	7	15	14	4	0	1	0	0	0	1	3	2	1	2	3	3	3	3	3	3	1	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr4:153601078G>A	uc003imw.1	-	1	114	c.8C>T	c.(7-9)GCT>GTT	p.A3V		NM_152680	NP_689893	Q6P9G4	TM154_HUMAN	transmembrane protein 154 precursor	3						integral to membrane					0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				TGCGCGGGGAGCCTGCATGTC	0.642													5	14					0	0	0	0	A	153601078	A	A	153601078	3	1	173	1	0	0	0	0	1	0	0	0	16137	971	34	4	571	4	TMEM154	4	153601078	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	30460555	153601078	37553198	37	32492											
MARCH6	10299	broad.mit.edu	37	chr5	10433762	10433762	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaatctggcaaacaaggctCatctccaccacctccacagt	13	7	6	15	0	3	0	1	0	2	0	5	1	4	0	4	2	1	2	4	2	3	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr5:10433762C>T	uc003jet.1	+	26	2882	c.2699C>T	c.(2698-2700)TCA>TTA	p.S900L	MARCH6_uc011cmu.1_Missense_Mutation_p.S852L|MARCH6_uc003jeu.1_Missense_Mutation_p.S598L|MARCH6_uc011cmv.1_Missense_Mutation_p.S795L|uc003jev.1_5'Flank	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	900	Cytoplasmic (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						AAACAAGGCTCATCTCCACCA	0.443													23	54					0	0	0	0	T	10433762	T	T	10433762	3	4	173	1	0	0	0	0	1	0	0	0	9358	838	29	2	2801	2	MARCH6	5	10433762	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08		10433762	170481498	38	32493											
CTNND2	1501	broad.mit.edu	37	chr5	11397249	11397249	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggttgctatggtagctggccGgatactggaaagacccttca	9	10	13	9	1	1	1	1	0	0	1	1	3	1	3	2	5	3	4	2	5	4	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr5:11397249G>A	uc003jfa.1	-	6	651	c.506C>T	c.(505-507)CCG>CTG	p.P169L	CTNND2_uc010itt.2_Missense_Mutation_p.P78L|CTNND2_uc011cmy.1_Intron|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_Intron	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	169					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GTAGCTGGCCGGATACTGGAA	0.587													44	74					0	0	0	0	A	11397249	A	A	11397249	3	1	173	1	0	0	0	0	1	0	0	0	4037	1116	39	1	3239	1	CTNND2	5	11397249	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	963487	11397249	169518011	39	32494											
SLC27A6	28965	broad.mit.edu	37	chr5	128365282	128365282	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttttcaggttatgaaggaaGagcaggaatggcttctatta	12	14	11	4	0	2	2	1	1	1	1	2	4	2	4	0	4	1	3	0	4	6	6			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr5:128365282G>C	uc003kuy.2	+	10	1961	c.1565G>C	c.(1564-1566)AGA>ACA	p.R522T	SLC27A6_uc003kuz.2_Missense_Mutation_p.R522T	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	522					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TATGAAGGAAGAGCAGGAATG	0.303													23	67					0	0	0	0	C	128365282	C	C	128365282	3	2	173	1	0	0	0	0	1	0	0	0	14594	942	33	2	1599	2	SLC27A6	5	128365282	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	116968033	128365282	52549978	40	32495											
SPOCK1	6695	broad.mit.edu	37	chr5	136448238	136448238	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagtgtttctgggccacgttCcccttcttttgcctaaagat	6	15	8	12	1	2	1	0	0	2	1	3	1	3	1	4	1	1	2	4	1	2	6			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr5:136448238C>T	uc003lbo.2	-	4	551	c.360G>A	c.(358-360)GGG>GGA	p.G120G	SPOCK1_uc003lbp.2_Silent_p.G120G	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	120					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGGCCACGTTCCCCTTCTTTT	0.488													22	70					0	0	0	0	T	136448238	T	T	136448238	2	4	173	1	0	0	0	0	0	0	0	1	15145	842	30	2		2	SPOCK1	5	136448238	Silent	SNP	C	TCGA-CV-5436-01A-01D-1512-08	8082956	136448238	44467022	41	32496											
CDYL	9425	broad.mit.edu	37	chr6	4892155	4892155	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaacaggacctctcccaacaAtgctaggaaacaaatctcca	17	6	5	13	0	2	0	0	0	2	0	4	2	2	2	3	2	4	1	3	2	6	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:4892155A>T	uc003mwi.2	+	4	526	c.395A>T	c.(394-396)AAT>ATT	p.N132I	CDYL_uc003mwj.2_Missense_Mutation_p.N78I|CDYL_uc003mwk.2_Intron|CDYL_uc011dhx.1_5'UTR|CDYL_uc011dhy.1_5'UTR	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	132					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		TCTCCCAACAATGCTAGGAAA	0.483													41	45					0	0	0	0	T	4892155	T	T	4892155	3	4	173	1	0	0	0	0	1	0	0	0	3200	101	4	5	239	5	CDYL	6	4892155	Missense_Mutation	SNP	A	TCGA-CV-5436-01A-01D-1512-08		4892155	166222912	42	32497											
ZNF184	7738	broad.mit.edu	37	chr6	27420364	27420364	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcgccagtatgaattctcTgatgctgaacaagatgggtc	10	12	10	9	1	2	4	0	3	2	1	5	4	2	4	1	1	2	2	1	1	4	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:27420364T>C	uc003njj.2	-	5	1785	c.974A>G	c.(973-975)CAG>CGG	p.Q325R	ZNF184_uc010jqv.2_Missense_Mutation_p.Q325R|ZNF184_uc003nji.2_Missense_Mutation_p.Q325R	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	325	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATGAATTCTCTGATGCTGAAC	0.403													32	42					0	0	0	0	C	27420364	C	C	27420364	3	2	173	1	0	0	0	0	1	0	0	0	17818	1580	55	5	1285	5	ZNF184	6	27420364	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	22528209	27420364	143694703	43	32498											
PGBD1	84547	broad.mit.edu	37	chr6	28264676	28264676	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtctgactcggaggaacctCtgtgggaactcagctcagga	10	8	13	10	1	4	1	2	1	2	0	5	5	4	5	1	4	3	1	1	4	2	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:28264676C>G	uc003nky.2	+	5	1096	c.726C>G	c.(724-726)CTC>CTG	p.L242L	PGBD1_uc003nkz.2_Silent_p.L242L	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	242					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						GGAGGAACCTCTGTGGGAACT	0.512													4	80					0	0	0	0	G	28264676	G	G	28264676	2	3	173	1	0	0	0	0	0	0	0	1	11835	900	32	2		2	PGBD1	6	28264676	Silent	SNP	C	TCGA-CV-5436-01A-01D-1512-08	844312	28264676	142850391	44	32499											
EYS	346007	broad.mit.edu	37	chr6	66204885	66204885	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtgtcccaacactcagcCacttagaattaacagtgtgc	13	10	7	11	0	1	1	1	0	0	1	2	1	2	1	2	0	4	0	2	0	5	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:66204885C>A	uc011dxu.1	-	4	957	c.419G>T	c.(418-420)TGG>TTG	p.W140L	EYS_uc003peq.2_Missense_Mutation_p.W140L|EYS_uc003per.1_Missense_Mutation_p.W140L|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	140					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						AACACTCAGCCACTTAGAATT	0.423													39	79					6.97489e-18	7.85778e-18	1	0	A	66204885	A	A	66204885	3	1	173	1	0	0	0	0	1	0	0	0	5357	595	21	4	9137	4	EYS	6	66204885	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	37940209	66204885	104910182	45	32500											
SYNCRIP	10492	broad.mit.edu	37	chr6	86328538	86328538	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatacaaatttcactcacatTtgattttttgctgcttgcct	9	19	4	9	0	2	1	2	1	0	0	2	1	2	1	1	0	4	2	1	0	3	8			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:86328538T>C	uc003pla.2	-	10	1819	c.1278A>G	c.(1276-1278)CAA>CAG	p.Q426Q	SYNCRIP_uc003pku.2_Silent_p.Q426Q|SYNCRIP_uc003pkw.2_Silent_p.Q391Q|SYNCRIP_uc003pky.2_Silent_p.Q328Q|SYNCRIP_uc003pkv.2_Silent_p.Q426Q|SYNCRIP_uc003pkx.2_Silent_p.Q274Q|SYNCRIP_uc003pkz.2_Silent_p.Q391Q	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	426	Interaction with APOBEC1.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		TCACTCACATTTGATTTTTTG	0.303													7	19					0	0	0	0	C	86328538	C	C	86328538	2	2	173	1	0	0	0	0	0	0	0	1	15510	1838	64	5		5	SYNCRIP	6	86328538	Silent	SNP	T	TCGA-CV-5436-01A-01D-1512-08	20123653	86328538	84786529	46	32501											
EPHA7	2045	broad.mit.edu	37	chr6	93956564	93956565	+	Missense_Mutation	DNP	TC	AA	AA																															ttgggtttcgaatcattttgTctagaattccaactatctgt																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:93956564_93956565TC>AA	uc003poe.2	-	15	2912_2913	c.2671_2672GA>TT	c.(2671-2673)GAC>TTC	p.D891F	EPHA7_uc003pof.2_Missense_Mutation_p.D886F|EPHA7_uc011eac.1_Missense_Mutation_p.D887F	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	891	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		AATCATTTTGTCTAGAATTCCA	0.431													44	112					0	0	0	0	AA	93956565	AA	AA	93956564	3	1	173	1	0	0	0	0	1	0	0	0	5196	1667	58	5	336	5	EPHA7	6	93956564	Missense_Mutation	DNP	TC	TCGA-CV-5436-01A-01D-1512-08	7628026	93956564	77158503	47	32502											
FUT9	10690	broad.mit.edu	37	chr6	96651080	96651080	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccatttttaattgtctgcAttatcctgggctgtttcatg	6	18	8	9	0	2	0	1	0	1	0	3	0	3	0	2	1	1	3	2	1	2	6			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:96651080A>G	uc003pop.3	+	3	390	c.49A>G	c.(49-51)ATT>GTT	p.I17V		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	17	Helical; Signal-anchor for type II membrane protein; (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		AATTGTCTGCATTATCCTGGG	0.423													69	119					0	0	0	0	G	96651080	G	G	96651080	3	3	173	1	0	0	0	0	1	0	0	0	6145	217	8	5	51	5	FUT9	6	96651080	Missense_Mutation	SNP	A	TCGA-CV-5436-01A-01D-1512-08	2694516	96651080	74463987	48	32503											
SOBP	55084	broad.mit.edu	37	chr6	107955178	107955178	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tagcatcgggcctccccttgGcgtcccgcctcggagccctc	3	8	11	19	4	0	0	0	0	0	0	5	1	2	1	6	3	2	1	6	3	1	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:107955178G>A	uc003prx.2	+	6	1634	c.1130G>A	c.(1129-1131)GGC>GAC	p.G377D		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	377	Pro-rich.						metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		CCTCCCCTTGGCGTCCCGCCT	0.647													47	97					0	0	0	0	A	107955178	A	A	107955178	3	1	173	1	0	0	0	0	1	0	0	0	14976	1203	42	4	1152	4	SOBP	6	107955178	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	11304098	107955178	63159889	49	32504											
TRAF3IP2	10758	broad.mit.edu	37	chr6	111912597	111912597	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagggaactccctggacctGagaggtctggggaggtcctg	7	8	17	9	0	1	2	0	2	1	1	3	6	3	5	3	6	1	0	3	6	1	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:111912597G>A	uc011ebc.1	-	3	1308	c.693C>T	c.(691-693)CTC>CTT	p.L231L	TRAF3IP2_uc003pvg.2_Silent_p.L231L|TRAF3IP2_uc003pvf.2_Silent_p.L231L|TRAF3IP2_uc010kdw.2_Silent_p.L231L|TRAF3IP2_uc010kdx.2_Silent_p.L231L	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	240					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		CCCTGGACCTGAGAGGTCTGG	0.572													62	99					0	0	0	0	A	111912597	A	A	111912597	2	1	173	1	0	0	0	0	0	0	0	1	16508	1277	45	2		2	TRAF3IP2	6	111912597	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	3957419	111912597	59202470	50	32505											
UTRN	7402	broad.mit.edu	37	chr6	144779962	144779962	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaggtttcatcagaatggAagaatgtatctcaacatttg	15	12	9	5	0	3	3	3	0	1	3	4	4	3	4	0	2	1	2	0	2	6	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:144779962A>C	uc003qkt.2	+	19	2433	c.2341A>C	c.(2341-2343)AAG>CAG	p.K781Q	UTRN_uc010khq.1_Missense_Mutation_p.K781Q	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	781	Interaction with SYNM.|Spectrin 5.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATCAGAATGGAAGAATGTATC	0.338													36	103					0	0	0	0	C	144779962	C	C	144779962	3	2	173	1	0	0	0	0	1	0	0	0	17171	247	9	5	2415	5	UTRN	6	144779962	Missense_Mutation	SNP	A	TCGA-CV-5436-01A-01D-1512-08	32867365	144779962	26335105	51	32506											
AKAP12	9590	broad.mit.edu	37	chr6	151672560	151672560	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtctcccagttaaccgacTccccagacaccacagaggag	12	5	8	16	1	1	2	0	0	1	2	3	4	2	3	5	1	1	1	5	1	1	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr6:151672560T>C	uc011eep.1	+	4	3274	c.3034T>C	c.(3034-3036)TCC>CCC	p.S1012P	AKAP12_uc003qoe.2_Missense_Mutation_p.S1012P|AKAP12_uc003qof.2_Missense_Mutation_p.S914P|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.S907P	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1012					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GTTAACCGACTCCCCAGACAC	0.577													3	77					0	0	0	0	C	151672560	C	C	151672560	3	2	173	1	0	0	0	0	1	0	0	0	448	1551	54	5	3073	5	AKAP12	6	151672560	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	6892598	151672560	19442507	52	32507											
OCM	654231	broad.mit.edu	37	chr7	5920406	5920407	+	5'Flank	INS	-	A	A																															cttaatttaaaaaaaaaaatINSaatctagacacacatacagt																								rs10235465		TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr7:5920406_5920407insA	uc003spe.3	+							NM_001097622	NP_001091091	P0CE72	ONCO_HUMAN	oncomodulin								calcium ion binding				0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		aaaaaaaaaaTAATCTAGACAC	0.228													---	---	---								A	5920407	A	A	5920406	6	5	173	0	1	1	1	0	0	0	0	0	10875	1421	49	0		0	OCM	7	5920406	5'Flank	INS	-	TCGA-CV-5436-01A-01D-1512-08		5920406	153218257	53	32508											
EIF2AK1	27102	broad.mit.edu	37	chr7	6077129	6077129	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caattcttgaaaaatttttgTtgcaacattggccataacat	14	15	5	7	0	1	1	0	1	1	0	1	1	1	1	1	1	3	2	1	1	5	7			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr7:6077129T>C	uc003spp.2	-	11	1404	c.1258A>G	c.(1258-1260)ACA>GCA	p.T420A	EIF2AK1_uc003spq.2_Missense_Mutation_p.T419A|EIF2AK1_uc011jwm.1_Missense_Mutation_p.T296A	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	420	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		AAAATTTTTGTTGCAACATTG	0.323													58	173					0	0	0	0	C	6077129	C	C	6077129	3	2	173	1	0	0	0	0	1	0	0	0	5018	1725	60	5	654	5	EIF2AK1	7	6077129	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	156723	6077129	153061534	54	32509											
TMEM195	392636	broad.mit.edu	37	chr7	15601453	15601453	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaaactgaaacatcctgctgGgcttctgggttcttcatttc	8	14	9	10	0	3	1	1	1	2	0	5	2	4	1	1	2	3	3	1	2	2	4			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr7:15601453G>T	uc003stb.1	-	1	188	c.18C>A	c.(16-18)GCC>GCA	p.A6A		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	6					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						CATCCTGCTGGGCTTCTGGGT	0.443													35	150					2.68265e-12	2.98445e-12	1	0	T	15601453	T	T	15601453	2	4	173	1	0	0	0	0	0	0	0	1	16183	1219	43	4		4	TMEM195	7	15601453	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	9524324	15601453	143537210	55	32510											
TBX20	57057	broad.mit.edu	37	chr7	35242348	35242348	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagatgatacccaggagctGagagacaaattatcagatgt	16	8	11	6	0	1	5	1	2	0	3	1	8	1	6	1	1	2	1	1	1	4	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr7:35242348G>C	uc011kas.1	-	8	1049	c.1038C>G	c.(1036-1038)CTC>CTG	p.L346L		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	346						nucleus	DNA binding			central_nervous_system(1)	1						CCCAGGAGCTGAGAGACAAAT	0.438													3	18					0	0	0	0	C	35242348	C	C	35242348	2	2	173	1	0	0	0	0	0	0	0	1	15722	1277	45	2		2	TBX20	7	35242348	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	19640895	35242348	123896315	56	32511											
AMPH	273	broad.mit.edu	37	chr7	38431514	38431514	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggggcccggaggagccgcGtcctcggtggtctccttggg	2	8	19	12	4	1	0	0	0	1	0	4	2	2	2	4	7	1	0	4	7	0	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr7:38431514G>A	uc003tgu.2	-	19	1782	c.1713C>T	c.(1711-1713)GAC>GAT	p.D571D	AMPH_uc003tgv.2_Silent_p.D529D|AMPH_uc003tgt.2_Silent_p.D456D|AMPH_uc003tgw.1_Silent_p.D594D|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	571					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						GAGGAGCCGCGTCCTCGGTGG	0.607													19	96					0	0	0	0	A	38431514	A	A	38431514	2	1	173	1	0	0	0	0	0	0	0	1	588	1136	40	1		1	AMPH	7	38431514	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	3189166	38431514	120707149	57	32512											
ZNF679	168417	broad.mit.edu	37	chr7	63726517	63726517	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaagtcttcggcaaattttCaaattccaatagacataaga	17	11	5	8	1	2	2	1	0	1	2	4	2	3	2	1	1	0	1	1	1	6	6			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr7:63726517C>T	uc003tsx.2	+	5	775	c.506C>T	c.(505-507)TCA>TTA	p.S169L		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	169	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						GGCAAATTTTCAAATTCCAAT	0.313													14	25					0	0	0	0	T	63726517	T	T	63726517	3	4	173	1	0	0	0	0	1	0	0	0	18153	838	29	2	520	2	ZNF679	7	63726517	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	25295003	63726517	95412146	58	32513											
STX1A	6804	broad.mit.edu	37	chr7	73118115	73118115	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagatggcggggttcccactCtccagcatgtcctccagctc	7	9	10	15	1	1	1	0	0	1	1	6	1	4	1	4	3	2	3	4	3	1	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr7:73118115C>G	uc003tyx.2	-	7	537	c.510G>C	c.(508-510)GAG>GAC	p.E170D	WBSCR22_uc003tyw.1_3'UTR|STX1A_uc003tyy.2_Missense_Mutation_p.E170D|STX1A_uc010lbj.1_Missense_Mutation_p.E170D	NM_004603	NP_004594	Q16623	STX1A_HUMAN	syntaxin 1A isoform 1	170	Cytoplasmic (Potential).				energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				GGTTCCCACTCTCCAGCATGT	0.637													50	84					0	0	0	0	G	73118115	G	G	73118115	3	3	173	1	0	0	0	0	1	0	0	0	15409	912	32	2	372	2	STX1A	7	73118115	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	9391598	73118115	86020548	59	32514											
PON3	5446	broad.mit.edu	37	chr7	95019514	95019514	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatatcaatatcttcagaGccactttctgcaaaagaagg	15	11	7	8	0	4	2	2	0	2	2	4	2	4	2	1	1	2	2	1	1	7	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr7:95019514G>C	uc003unt.2	-	3	178	c.153C>G	c.(151-153)GGC>GGG	p.G51G	PON1_uc011kih.1_Intron|PON3_uc011kii.1_Silent_p.G51G	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	51					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TATCTTCAGAGCCACTTTCTG	0.378													101	225					0	0	0	0	C	95019514	C	C	95019514	2	2	173	1	0	0	0	0	0	0	0	1	12305	958	34	4		4	PON3	7	95019514	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	21901399	95019514	64119149	60	32515											
DNAJC2	27000	broad.mit.edu	37	chr7	102982244	102982244	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggatcaagtgttttcagcatGggaaactcttccaactgcaa	12	11	9	9	0	3	0	2	0	1	0	4	2	4	2	1	2	4	3	1	2	4	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr7:102982244G>A	uc003vbo.2	-	2	473	c.222C>T	c.(220-222)CCC>CCT	p.P74P	DNAJC2_uc003vbn.2_5'UTR|DNAJC2_uc010lix.2_Silent_p.P74P|DNAJC2_uc003vbp.2_5'UTR|DNAJC2_uc003vbq.1_RNA|DNAJC2_uc003vbr.1_Silent_p.P74P	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	74					'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1						TTTTCAGCATGGGAAACTCTT	0.373													57	115					0	0	0	0	A	102982244	A	A	102982244	2	1	173	1	0	0	0	0	0	0	0	1	4661	1335	47	4		4	DNAJC2	7	102982244	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	7962730	102982244	56156419	61	32516											
MSR1	4481	broad.mit.edu	37	chr8	16032716	16032716	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgccactattccaatgagaGggatgagaactgcaaacacg	14	7	10	10	1	0	2	0	2	0	2	1	5	1	3	2	1	4	1	2	1	4	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr8:16032716G>T	uc003wwz.2	-	3	395	c.197C>A	c.(196-198)CCT>CAT	p.P66H	MSR1_uc010lsu.2_Missense_Mutation_p.P84H|MSR1_uc003wxa.2_Missense_Mutation_p.P66H|MSR1_uc003wxb.2_Missense_Mutation_p.P66H|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	66	Helical; Signal-anchor for type II membrane protein; (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TCCAATGAGAGGGATGAGAAC	0.413													25	61					4.26978e-12	4.72062e-12	1	0	T	16032716	T	T	16032716	3	4	173	1	0	0	0	0	1	0	0	0	9939	1000	35	4	1238	4	MSR1	8	16032716	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08		16032716	130331306	62	32517											
PRKDC	5591	broad.mit.edu	37	chr8	48845609	48845609	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaacagtctgtatttcaaGtgtaagatccaatttctcaa	13	13	5	10	0	3	1	2	0	2	1	5	1	4	1	2	0	1	2	2	0	6	4			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr8:48845609G>C	uc003xqi.2	-	16	1804	c.1747C>G	c.(1747-1749)CTT>GTT	p.L583V	PRKDC_uc003xqj.2_Missense_Mutation_p.L583V|PRKDC_uc011ldh.1_Missense_Mutation_p.L583V	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	583					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGTATTTCAAGTGTAAGATCC	0.299								NHEJ					8	28					0	0	0	0	C	48845609	C	C	48845609	3	2	173	1	0	0	0	0	1	0	0	0	12583	1029	36	4	10922	4	PRKDC	8	48845609	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	32812893	48845609	97518413	63	32518											
RP1	6101	broad.mit.edu	37	chr8	55537622	55537622	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctctgcagatgtgtcacctAtggagcgaagcagtaatcaa	12	10	10	9	1	3	1	2	0	1	1	4	3	3	2	1	1	3	3	1	1	4	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr8:55537622A>G	uc003xsd.1	+	4	1328	c.1180A>G	c.(1180-1182)ATG>GTG	p.M394V	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	394					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGTGTCACCTATGGAGCGAAG	0.423													29	105					0	0	0	0	G	55537622	G	G	55537622	3	3	173	1	0	0	0	0	1	0	0	0	13597	449	16	5	1190	5	RP1	8	55537622	Missense_Mutation	SNP	A	TCGA-CV-5436-01A-01D-1512-08	6692013	55537622	90826400	64	32519											
RSPO2	340419	broad.mit.edu	37	chr8	108972911	108972911	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaactactcacccacacattCcatggtttcttctaatggtg	11	13	5	12	0	3	0	1	0	2	0	4	0	4	0	2	2	2	1	2	2	3	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr8:108972911C>T	uc003yms.2	-	4	1076	c.418G>A	c.(418-420)GAA>AAA	p.E140K	RSPO2_uc003ymq.2_Missense_Mutation_p.E73K|RSPO2_uc003ymr.2_Missense_Mutation_p.E77K	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	140					Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CCCACACATTCCATGGTTTCT	0.348													22	149					0	0	0	0	T	108972911	T	T	108972911	3	4	173	1	0	0	0	0	1	0	0	0	13775	864	30	2	325	2	RSPO2	8	108972911	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	53435289	108972911	37391111	65	32520											
COL22A1	169044	broad.mit.edu	37	chr8	139606419	139606419	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgtacgccgggggcatctGggccaggaggtaggcgagtc	7	6	18	10	3	1	0	0	0	1	0	2	2	1	1	2	6	1	3	2	6	2	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr8:139606419G>A	uc003yvd.2	-	63	4903	c.4456C>T	c.(4456-4458)CAG>TAG	p.Q1486*	COL22A1_uc011ljo.1_Nonsense_Mutation_p.Q766*	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1486	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGGGGCATCTGGGCCAGGAGG	0.582										HNSCC(7;0.00092)			101	78					0	0	0	0	A	139606419	A	A	139606419	4	1	173	1	0	0	0	0	0	1	0	0	3696	1357	47	4	436	4	COL22A1	8	139606419	Nonsense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	30633508	139606419	6757603	66	32521											
HEATR7A	727957	broad.mit.edu	37	chr8	145223234	145223234	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctggacgccatcaccgataAggaccccctggtgcaggagc	9	5	13	14	2	1	0	1	0	0	0	1	4	1	3	4	4	2	2	4	4	1	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr8:145223234A>G	uc003zbk.3	+	4	296	c.59A>G	c.(58-60)AAG>AGG	p.K20R	HEATR7A_uc003zbg.2_Missense_Mutation_p.K20R|HEATR7A_uc003zbh.3_Missense_Mutation_p.K20R|HEATR7A_uc003zbi.3_Missense_Mutation_p.K20R|HEATR7A_uc011lla.1_Missense_Mutation_p.K20R|HEATR7A_uc010mft.2_Missense_Mutation_p.K20R	NM_032450	NP_115826	Q8NDA8	HTR7A_HUMAN	HEAT repeat containing 7A isoform 1	20	HEAT 1.						binding				0						ATCACCGATAAGGACCCCCTG	0.667													27	31					0	0	0	0	G	145223234	G	G	145223234	3	3	173	1	0	0	0	0	1	0	0	0	7073	72	3	5	65	5	HEATR7A	8	145223234	Missense_Mutation	SNP	A	TCGA-CV-5436-01A-01D-1512-08	5616815	145223234	1140788	67	32522											
PHF2	5253	broad.mit.edu	37	chr9	96437264	96437264	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctttaagtcccggtcgaaGaaaaggaaaggctcagacga	15	7	11	8	3	2	2	1	0	1	2	4	5	3	3	1	3	0	1	1	3	5	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr9:96437264G>C	uc004aub.2	+	19	2829	c.2682G>C	c.(2680-2682)AAG>AAC	p.K894N	PHF2_uc011lug.1_Missense_Mutation_p.K777N|PHF2_uc004auc.2_Missense_Mutation_p.K314N	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	894					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		CCCGGTCGAAGAAAAGGAAAG	0.582													17	94					0	0	0	0	C	96437264	C	C	96437264	3	2	173	1	0	0	0	0	1	0	0	0	11885	933	33	2	2756	2	PHF2	9	96437264	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08		96437264	44776167	68	32523											
FPGS	2356	broad.mit.edu	37	chr9	130570884	130570885	+	Frame_Shift_Ins	INS	-	C	C																															aggccctcgaggaaggggggINSccgccgctgaccctgggcct																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr9:130570884_130570885insC	uc004bsg.1	+	10	920_921	c.870_871insC	c.(868-873)GGGCCGfs	p.G290fs	FPGS_uc004bsh.1_Frame_Shift_Ins_p.G107fs|FPGS_uc011mal.1_Frame_Shift_Ins_p.G264fs|FPGS_uc004bsi.1_Frame_Shift_Ins_p.G240fs	NM_004957	NP_004948	Q05932	FOLC_HUMAN	folylpolyglutamate synthase isoform a precursor	290_291					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity				0					L-Glutamic Acid(DB00142)	AGGAAGGGGGGCCGCCGCTGAC	0.698													---	---	---								C	130570885	C	C	130570884	7	5	173	1	0	1	1	0	0	0	0	0	6070	1190	42	0	908	0	FPGS	9	130570884	Frame_Shift_Ins	INS	-	TCGA-CV-5436-01A-01D-1512-08	34133620	130570884	10642547	69	32524											
IER5L	389792	broad.mit.edu	37	chr9	131939365	131939365	+	Frame_Shift_Del	DEL	C	-	-																															ggcgcccccggggggctcggCccccagcccgcccgcatcct																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr9:131939365delC	uc010myt.1	-	1	1176	c.967delG	c.(967-969)GCCfs	p.A323fs		NM_203434	NP_982258	Q5T953	IER5L_HUMAN	immediate early response 5-like	323											0		Ovarian(14;0.0448)|Medulloblastoma(224;0.235)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)		gggggctcggcccccagcccg	0.537													---	---	---								-	131939365	-	-	131939365	7	5	173	1	0	1	0	1	0	0	0	0	7548	739	26	0	251	0	IER5L	9	131939365	Frame_Shift_Del	DEL	C	TCGA-CV-5436-01A-01D-1512-08	1368481	131939365	9274066	70	32525											
NOTCH1	4851	broad.mit.edu	37	chr9	139412212	139412212	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggccgacgcaccgggcatgCagatgcactggaactcccca	9	4	12	16	4	0	1	0	0	0	1	1	3	1	2	4	3	3	4	4	3	1	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr9:139412212C>T	uc004chz.2	-	8	1433	c.1433G>A	c.(1432-1434)TGC>TAC	p.C478Y		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	478	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACCGGGCATGCAGATGCACTG	0.672			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			104	29					0	0	0	0	T	139412212	T	T	139412212	3	4	173	1	0	0	0	0	1	0	0	0	10601	710	25	4	6342	4	NOTCH1	9	139412212	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	7472847	139412212	1801219	71	32526											
EDF1	8721	broad.mit.edu	37	chr9	139760831	139760831	+	5'Flank	DEL	G	-	-																															cccattggctggctgcacgcGgggggcgggcacttcccgtg																								rs111812525		TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr9:139760831delG	uc004cjt.1	-						EDF1_uc004cju.1_5'Flank	NM_003792	NP_003783	O60869	EDF1_HUMAN	endothelial differentiation-related factor 1						endothelial cell differentiation|multicellular organismal development|positive regulation of DNA binding|positive regulation of transcription, DNA-dependent|regulation of lipid metabolic process|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleolus|nucleus	calmodulin binding|protein binding|protein binding|sequence-specific DNA binding|transcription coactivator activity				0	all_cancers(76;0.0841)|all_epithelial(76;0.217)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		GGCTGCACGCGGGGGGCGGGC	0.746													---	---	---								-	139760831	-	-	139760831	6	5	173	0	1	1	0	1	0	0	0	0	4936	1131	39	0		0	EDF1	9	139760831	5'Flank	DEL	G	TCGA-CV-5436-01A-01D-1512-08	348619	139760831	1452600	72	32527											
ABCA2	20	broad.mit.edu	37	chr9	139905642	139905642	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacgggccccctcaccaatCttggcgtagtactcgttgat	7	10	9	15	3	2	1	1	1	1	0	3	1	2	1	4	2	1	3	4	2	3	4			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr9:139905642C>T	uc011mem.1	-	37	6064	c.5916G>A	c.(5914-5916)AAG>AAA	p.K1972K	ABCA2_uc011mel.1_Silent_p.K1973K|ABCA2_uc004ckl.1_Silent_p.K1903K|ABCA2_uc004ckm.1_Silent_p.K2003K	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1972					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCTCACCAATCTTGGCGTAGT	0.607													34	119					0	0	0	0	T	139905642	T	T	139905642	2	4	173	1	0	0	0	0	0	0	0	1	32	912	32	2		2	ABCA2	9	139905642	Silent	SNP	C	TCGA-CV-5436-01A-01D-1512-08	144811	139905642	1307789	73	32528											
DIP2C	22982	broad.mit.edu	37	chr10	468941	468941	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgggagtccccctgcaCtgagccttcatcttctgagc	5	10	10	16	0	3	2	1	2	2	0	4	3	4	3	4	1	3	1	4	1	0	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr10:468941C>A	uc001ifp.2	-	5	517	c.427G>T	c.(427-429)GTG>TTG	p.V143L	DIP2C_uc009xhk.1_Missense_Mutation_p.Q144H	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	143						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		TCCCCCTGCACTGAGCCTTCA	0.562													58	128					7.10663e-31	8.21415e-31	1	0	A	468941	A	A	468941	3	1	173	1	0	0	0	0	1	0	0	0	4551	565	20	4	4375	4	DIP2C	10	468941	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08		468941	135065806	74	32529											
ANKRD30A	91074	broad.mit.edu	37	chr10	37508487	37508487	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaatacattggtttcagaaCatgcacaaagagaccaacgt	18	8	7	8	1	1	2	1	0	0	2	1	3	1	2	1	1	4	2	1	1	6	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr10:37508487C>T	uc001iza.1	+	34	3778	c.3679C>T	c.(3679-3681)CAT>TAT	p.H1227Y		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1283	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GGTTTCAGAACATGCACAAAG	0.373													19	51					0	0	0	0	T	37508487	T	T	37508487	3	4	173	1	0	0	0	0	1	0	0	0	658	478	17	4	3813	4	ANKRD30A	10	37508487	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	37039546	37508487	98026260	75	32530											
SORBS1	10580	broad.mit.edu	37	chr10	97174295	97174295	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcaggctccgagactctgcGgaggtcctccggggcaggag	6	6	17	12	3	2	1	1	0	1	1	5	4	5	3	3	6	1	2	3	6	0	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr10:97174295G>A	uc001kkp.2	-	7	811	c.766C>T	c.(766-768)CGC>TGC	p.R256C	SORBS1_uc001kkl.2_5'UTR|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Missense_Mutation_p.R256C|SORBS1_uc001kkq.2_Missense_Mutation_p.R187C|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Missense_Mutation_p.R224C|SORBS1_uc001kkw.2_Missense_Mutation_p.R256C|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Missense_Mutation_p.R454C|SORBS1_uc001kkx.1_Missense_Mutation_p.R224C	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	256					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GAGACTCTGCGGAGGTCCTCC	0.637													24	58					0	0	0	0	A	97174295	A	A	97174295	3	1	173	1	0	0	0	0	1	0	0	0	14991	1116	39	1	3409	1	SORBS1	10	97174295	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	59665808	97174295	38360452	76	32531											
RGS10	6001	broad.mit.edu	37	chr10	121302235	121302237	+	5'Flank	DEL	GAG	-	-																															gcgaggaggaggaggagggcGaggaggaggaggaggagggc																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr10:121302235_121302237delGAG	uc001leg.2	-							NM_001005339	NP_001005339	O43665	RGS10_HUMAN	regulator of G-protein signaling 10 isoform a						negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|protein binding|signal transducer activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00105)|GBM - Glioblastoma multiforme(135;0.195)		ggaggagggcgaggaggaggagg	0.552													---	---	---								-	121302237	-	-	121302235	6	5	173	0	1	1	0	1	0	0	0	0	13358	1073	37	0		0	RGS10	10	121302235	5'Flank	DEL	GAG	TCGA-CV-5436-01A-01D-1512-08	24127940	121302235	14232512	77	32532											
UBQLN3	50613	broad.mit.edu	37	chr11	5529987	5529987	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccaaactgctcctggactgCgttaagcattgggtccataa	10	10	10	11	1	0	0	0	0	0	0	2	1	2	1	3	2	4	3	3	2	3	3	rs144033515	by1000genomes	TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr11:5529987C>T	uc001may.1	-	2	888	c.802G>A	c.(802-804)GCA>ACA	p.A268T	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	268										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCTGGACTGCGTTAAGCATT	0.517													70	136					0	0	0	0	T	5529987	T	T	5529987	3	4	173	1	0	0	0	0	1	0	0	0	16966	768	27	1	1169	1	UBQLN3	11	5529987	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08		5529987	129476529	78	32533											
BTBD10	84280	broad.mit.edu	37	chr11	13438772	13438772	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actctcctttctcattgggtCgtgtaaagttatgttctcgg	6	17	9	9	2	3	0	1	0	3	0	7	0	3	0	1	2	0	3	1	2	3	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr11:13438772C>T	uc001mkz.2	-	5	877	c.620G>A	c.(619-621)CGA>CAA	p.R207Q	BTBD10_uc010rcl.1_Missense_Mutation_p.R215Q|BTBD10_uc001mla.2_Missense_Mutation_p.R191Q|BTBD10_uc009ygn.2_Intron|BTBD10_uc010rcm.1_Missense_Mutation_p.R159Q|BTBD10_uc010rcn.1_Missense_Mutation_p.R176Q|BTBD10_uc009ygo.2_Missense_Mutation_p.R159Q	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	207	BTB.					nucleus					0				Epithelial(150;0.0214)		CTCATTGGGTCGTGTAAAGTT	0.378													81	155					0	0	0	0	T	13438772	T	T	13438772	3	4	173	1	0	0	0	0	1	0	0	0	1543	884	31	1	827	1	BTBD10	11	13438772	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	7908785	13438772	121567744	79	32534											
CYP2R1	120227	broad.mit.edu	37	chr11	14901976	14901976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttccaaaaggcaggatgcCaatccatggaaaggcattat	14	10	9	8	0	0	0	0	0	0	0	2	2	2	2	3	4	1	2	3	4	5	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr11:14901976C>T	uc001mlr.2	-	3	706	c.706G>A	c.(706-708)GGC>AGC	p.G236S	CYP2R1_uc001mlo.2_Intron|CYP2R1_uc001mlp.2_Missense_Mutation_p.G119S|CYP2R1_uc001mlq.2_RNA|CYP2R1_uc001mls.1_Missense_Mutation_p.G181S	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	236					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	GGCAGGATGCCAATCCATGGA	0.398													31	83					0	0	0	0	T	14901976	T	T	14901976	3	4	173	1	0	0	0	0	1	0	0	0	4190	594	21	4	811	4	CYP2R1	11	14901976	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	1463204	14901976	120104540	80	32535											
SPTY2D1	144108	broad.mit.edu	37	chr11	18636375	18636376	+	Frame_Shift_Ins	INS	-	A	A																															cagaccgccccggggggcccINSaagccactcactggtcgtcg																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr11:18636375_18636376insA	uc001moy.2	-	3	1661_1662	c.1445_1446insT	c.(1444-1446)TTGfs	p.L482fs	SPTY2D1_uc010rdi.1_Frame_Shift_Ins_p.L482fs	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	482	Ser-rich.									breast(1)	1						CCGGGGGGCCCAAGCCACTCAC	0.589													---	---	---								A	18636376	A	A	18636375	7	5	173	1	0	1	1	0	0	0	0	0	15192	593	21	0	627	0	SPTY2D1	11	18636375	Frame_Shift_Ins	INS	-	TCGA-CV-5436-01A-01D-1512-08	3734399	18636375	116370141	81	32536											
KIAA0652	9776	broad.mit.edu	37	chr11	46681003	46681003	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagactctcaagaagtgtgtAccacctctttttccacctcc	10	12	5	14	0	2	2	1	0	2	2	5	2	4	2	5	0	1	1	5	0	4	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr11:46681003A>G	uc009yld.2	+	11	1441	c.757A>G	c.(757-759)ACC>GCC	p.T253A	KIAA0652_uc001nda.2_Missense_Mutation_p.T253A|KIAA0652_uc001ndb.2_Missense_Mutation_p.T253A|KIAA0652_uc001ncz.2_Missense_Mutation_p.T253A|KIAA0652_uc001ndc.2_Missense_Mutation_p.T253A|KIAA0652_uc010rgv.1_Missense_Mutation_p.T174A	NM_001142673	NP_001136145	O75143	ATG13_HUMAN	autophagy-related protein 13 isoform 1	253					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding				0				GBM - Glioblastoma multiforme(35;0.226)		AGAAGTGTGTACCACCTCTTT	0.433													33	70					0	0	0	0	G	46681003	G	G	46681003	3	3	173	1	0	0	0	0	1	0	0	0	8227	391	14	5	791	5	KIAA0652	11	46681003	Missense_Mutation	SNP	A	TCGA-CV-5436-01A-01D-1512-08	28044628	46681003	88325513	82	32537											
OR5L1	219437	broad.mit.edu	37	chr11	55579760	55579760	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtggagatgctgacaaagTggccaccgtgttctacacag	11	9	12	9	1	1	2	0	1	1	1	1	3	1	2	2	2	2	2	2	2	3	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr11:55579760T>G	uc001nhw.1	+	1	818	c.818T>G	c.(817-819)GTG>GGG	p.V273G		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				GCTGACAAAGTGGCCACCGTG	0.473													33	70					0	0	0	0	G	55579760	G	G	55579760	3	3	173	1	0	0	0	0	1	0	0	0	11224	1696	59	5	820	5	OR5L1	11	55579760	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	8898757	55579760	79426756	83	32538											
SCYL1	57410	broad.mit.edu	37	chr11	65304218	65304218	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccccaaagacccacgcctGaaggtgagtgtcctggccta	9	8	10	14	1	0	3	0	2	0	1	2	3	2	3	6	2	0	0	6	2	3	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr11:65304218G>A	uc001oea.1	+	13	1890	c.1813G>A	c.(1813-1815)GAA>AAA	p.E605K	SCYL1_uc009yqk.2_Missense_Mutation_p.E605K|SCYL1_uc001oeb.1_Missense_Mutation_p.E605K|SCYL1_uc001oec.1_Missense_Mutation_p.E605K|SCYL1_uc001oed.1_Missense_Mutation_p.E462K|SCYL1_uc001oee.1_Missense_Mutation_p.E249K	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	605	Pro-rich.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						ACCCACGCCTGAAGGTGAGTG	0.607													49	125					0	0	0	0	A	65304218	A	A	65304218	3	1	173	1	0	0	0	0	1	0	0	0	14012	1291	45	2	1863	2	SCYL1	11	65304218	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	9724458	65304218	69702298	84	32539											
MTMR2	8898	broad.mit.edu	37	chr11	95591793	95591793	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcaaatcgtaaattcctaaTatcctagaaaagatttagga	18	11	6	6	1	0	2	0	0	0	2	3	3	2	3	2	1	1	2	2	1	9	7			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr11:95591793T>C	uc001pfu.2	-	6	725	c.472A>G	c.(472-474)ATT>GTT	p.I158V	MTMR2_uc001pfv.2_Missense_Mutation_p.I86V|MTMR2_uc001pfs.2_Missense_Mutation_p.I86V|MTMR2_uc001pft.2_Missense_Mutation_p.I86V|MTMR2_uc010ruj.1_Missense_Mutation_p.I141V	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	158						nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AAATTCCTAATATCCTAGAAA	0.313													61	106					0	0	0	0	C	95591793	C	C	95591793	3	2	173	1	0	0	0	0	1	0	0	0	9997	1406	49	5	1499	5	MTMR2	11	95591793	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	30287575	95591793	39414723	85	32540											
RPS25	6230	broad.mit.edu	37	chr11	118888677	118888677	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttatttctaccttctttttGgccttgcccccggatttgtt	3	20	6	12	1	2	0	0	0	2	0	2	1	2	1	4	2	2	1	4	2	2	9	rs3209457		TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr11:118888677G>A	uc001pun.2	-	2	153	c.90C>T	c.(88-90)GCC>GCT	p.A30A	TRAPPC4_uc010ryn.1_5'Flank|TRAPPC4_uc010ryo.1_5'Flank|TRAPPC4_uc010ryp.1_5'Flank|TRAPPC4_uc001pup.2_5'Flank|TRAPPC4_uc010ryq.1_5'Flank	NM_001028	NP_001019	P62851	RS25_HUMAN	ribosomal protein S25	30					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|RNA binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		CCTTCTTTTTGGCCTTGCCCC	0.468													63	128					0	0	0	0	A	118888677	A	A	118888677	2	1	173	1	0	0	0	0	0	0	0	1	13701	1335	47	4		4	RPS25	11	118888677	Silent	SNP	G	TCGA-CV-5436-01A-01D-1512-08	23296884	118888677	16117839	86	32541											
SLC2A3	6515	broad.mit.edu	37	chr12	8090336	8090336	+	5'Flank	DEL	G	-	-																															tcaaaaaaaaaaaaaaaaaaGaataataggacaaaagagtt																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr12:8090336delG	uc001qtr.2	-						SLC2A3_uc001qts.2_5'Flank	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose						carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		aaaaaaaaaagaaTAATAGGA	0.169													---	---	---								-	8090336	-	-	8090336	6	5	173	0	1	1	0	1	0	0	0	0	14609	957	33	0		0	SLC2A3	12	8090336	5'Flank	DEL	G	TCGA-CV-5436-01A-01D-1512-08		8090336	125761559	87	32542											
WBP11	51729	broad.mit.edu	37	chr12	14946725	14946725	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acggtgcacaaattcatcccCgtcactttctccatctgatt	9	13	5	14	2	4	1	2	1	2	0	6	1	5	1	3	1	1	1	3	1	1	3	rs150908147		TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr12:14946725C>T	uc001rci.2	-	8	1014	c.853G>A	c.(853-855)GGG>AGG	p.G285R		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	285	Asp-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						AATTCATCCCCGTCACTTTCT	0.423													128	262					0	0	0	0	T	14946725	T	T	14946725	3	4	173	1	0	0	0	0	1	0	0	0	17326	652	23	1	1092	1	WBP11	12	14946725	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	6856389	14946725	118905170	88	32543											
BICD1	636	broad.mit.edu	37	chr12	32480416	32480416	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagagcgggaaaaggccattCttttggccaacctacaggag	12	8	12	9	1	1	1	0	0	1	1	1	3	1	3	3	4	3	0	3	4	5	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr12:32480416C>T	uc001rku.2	+	5	1108	c.1027C>T	c.(1027-1029)CTT>TTT	p.L343F	BICD1_uc001rkv.2_Missense_Mutation_p.L343F|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	343	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			AAAGGCCATTCTTTTGGCCAA	0.527													37	93					0	0	0	0	T	32480416	T	T	32480416	3	4	173	1	0	0	0	0	1	0	0	0	1431	913	32	2	1045	2	BICD1	12	32480416	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	17533691	32480416	101371479	89	32544											
MLL2	8085	broad.mit.edu	37	chr12	49428450	49428450	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctagcagagacacttgctgtCtggagtccaccaaagcacag	12	7	10	12	0	1	1	0	0	1	1	2	3	2	2	2	1	3	3	2	1	2	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr12:49428450C>G	uc001rta.3	-	36	10356	c.10356_splice	c.e36-1	p.R3452_splice		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2						chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CACTTGCTGTCTGGAGTCCAC	0.547			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			7	27					0	0	0	0	G	49428450	G	G	49428450	5	3	173	1	0	0	0	0	0	0	1	0	9674	927	32	2	6334	2	MLL2	12	49428450	Splice_Site	SNP	C	TCGA-CV-5436-01A-01D-1512-08	16948034	49428450	84423445	90	32545											
MLL2	8085	broad.mit.edu	37	chr12	49431260	49431264	+	Frame_Shift_Del	DEL	CTGGG	-	-																															tcatgtggcaaagacatggcCtgggcagggcctggtgcaga																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr12:49431260_49431264delCTGGG	uc001rta.3	-	34	9875_9879	c.9875_9879delCCCAG	c.(9874-9879)GCCCAGfs	p.A3292fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3292_3293	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AAGACATGGCCTGGGCAGGGCCTGG	0.522			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								-	49431264	-	-	49431260	7	5	173	1	0	1	0	1	0	0	0	0	9674	680	24	0	6818	0	MLL2	12	49431260	Frame_Shift_Del	DEL	CTGGG	TCGA-CV-5436-01A-01D-1512-08	2810	49431260	84420635	91	32546											
DNAJC14	85406	broad.mit.edu	37	chr12	56222003	56222003	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaagttgctagaagaaccaTttcctccctcagagtaaggc	14	9	8	10	0	1	3	1	0	0	3	3	3	3	3	3	1	2	3	3	1	6	4			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr12:56222003T>A	uc001shx.1	-	2	644	c.440A>T	c.(439-441)AAT>ATT	p.N147I	DNAJC14_uc001shu.1_Missense_Mutation_p.N147I|DNAJC14_uc009zob.1_Missense_Mutation_p.N147I|DNAJC14_uc001shy.1_Missense_Mutation_p.N147I	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	147					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						AGAAGAACCATTTCCTCCCTC	0.483													91	161					0	0	0	0	A	56222003	A	A	56222003	3	1	173	1	0	0	0	0	1	0	0	0	4655	1493	52	5	1692	5	DNAJC14	12	56222003	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	6790743	56222003	77629892	92	32547											
PAN2	9924	broad.mit.edu	37	chr12	56712923	56712923	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatcattcgttttcggggcaTatggaacaggtagacagtgt	11	12	12	6	2	1	1	1	0	0	1	3	2	1	2	0	4	1	3	0	4	4	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr12:56712923T>C	uc001skx.2	-	24	3698	c.3325A>G	c.(3325-3327)ATG>GTG	p.M1109V	CNPY2_uc001sku.1_5'Flank|CNPY2_uc001skv.2_5'Flank|PAN2_uc001skw.2_Missense_Mutation_p.M257V|PAN2_uc001skz.2_Missense_Mutation_p.M1108V|PAN2_uc001sky.2_Missense_Mutation_p.M1105V	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	1109	Exonuclease.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TTTCGGGGCATATGGAACAGG	0.483													24	55					0	0	0	0	C	56712923	C	C	56712923	3	2	173	1	0	0	0	0	1	0	0	0	11468	1406	49	5	295	5	PAN2	12	56712923	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	490920	56712923	77138972	93	32548											
DCLK1	9201	broad.mit.edu	37	chr13	36700037	36700037	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcctcaaaagatcggaaccGgtctggggagatggcataca	12	6	14	9	2	2	2	1	0	1	2	3	4	2	3	2	6	2	1	2	6	4	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr13:36700037G>A	uc001uvf.2	-	2	471	c.238C>T	c.(238-240)CGG>TGG	p.R80W		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	80	Doublecortin 1.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GATCGGAACCGGTCTGGGGAG	0.507													40	122					0	0	0	0	A	36700037	A	A	36700037	3	1	173	1	0	0	0	0	1	0	0	0	4308	1115	39	1	2019	1	DCLK1	13	36700037	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08		36700037	78469841	94	32549											
KCTD4	386618	broad.mit.edu	37	chr13	45768678	45768678	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatactccttttctttttCtcttctgtttattttacgct	4	25	2	10	1	4	0	1	0	3	0	6	0	5	0	1	0	2	2	1	0	3	11			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr13:45768678C>G	uc001uzx.3	-	2	429	c.25G>C	c.(25-27)GAA>CAA	p.E9Q	GTF2F2_uc001uzv.2_Intron|GTF2F2_uc001uzw.2_Intron	NM_198404	NP_940686	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerisation domain	9						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)		TTTTCTTTTTCTCTTCTGTTT	0.388													93	160					0	0	0	0	G	45768678	G	G	45768678	3	3	173	1	0	0	0	0	1	0	0	0	8150	922	32	2	758	2	KCTD4	13	45768678	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	9068641	45768678	69401200	95	32550											
LCP1	3936	broad.mit.edu	37	chr13	46721156	46721156	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggttccctcggacaacaTctgtggctgtgacaaactgc	8	10	12	11	1	1	1	0	1	1	0	3	2	2	2	1	4	3	2	1	4	2	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr13:46721156T>A	uc001vaz.3	-	10	1187	c.1061A>T	c.(1060-1062)GAT>GTT	p.D354V	LCP1_uc001vay.3_5'Flank|LCP1_uc001vba.3_Missense_Mutation_p.D354V	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	354	CH 2.|Actin-binding 1.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TCGGACAACATCTGTGGCTGT	0.532			T	BCL6	NHL 								25	59					0	0	0	0	A	46721156	A	A	46721156	3	1	173	1	0	0	0	0	1	0	0	0	8731	1435	50	5	850	5	LCP1	13	46721156	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	952478	46721156	68448722	96	32551											
DCUN1D2	55208	broad.mit.edu	37	chr13	114112358	114112358	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctgcctagaaaaggctgcGttttccacctgtgactactg	8	12	10	11	1	0	2	0	1	0	1	1	2	1	2	3	1	4	3	3	1	4	4			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr13:114112358G>A	uc001vtr.1	-	7	805	c.766C>T	c.(766-768)CGC>TGC	p.R256C	DCUN1D2_uc001vts.1_RNA|DCUN1D2_uc010agw.1_Missense_Mutation_p.R123C	NM_001014283	NP_001014305	Q6PH85	DCNL2_HUMAN	DCN1, defective in cullin neddylation 1, domain	256											0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.029)|GBM - Glioblastoma multiforme(44;0.234)			AAAAGGCTGCGTTTTCCACCT	0.443											OREG0022535	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	446					0	0	0	0	A	114112358	A	A	114112358	3	1	173	1	0	0	0	0	1	0	0	0	4331	1145	40	1	17	1	DCUN1D2	13	114112358	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	67391202	114112358	1057520	97	32552											
PARP2	10038	broad.mit.edu	37	chr14	20825824	20825825	+	In_Frame_Ins	INS	-	GCG	GCG																															gtacagtgccattaggaccaINSgcaagtgacacaggaattct																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr14:20825824_20825825insGCG	uc001vxc.2	+	16	1648_1649	c.1620_1621insGCG	c.(1618-1623)insGCG	p.541_542insA	PARP2_uc001vxd.2_In_Frame_Ins_p.528_529insA|PARP2_uc001vxb.1_3'UTR	NM_005484	NP_005475	Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase family, member 2	541_542	PARP catalytic.				protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			ovary(1)|pancreas(1)	2	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		CATTAGGACCAGCAAGTGACAC	0.416								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					---	---	---								GCG	20825825	GCG	GCG	20825824	7	5	173	1	0	1	1	0	0	0	0	0	11515	175	7	0	1682	0	PARP2	14	20825824	In_Frame_Ins	INS	-	TCGA-CV-5436-01A-01D-1512-08		20825824	86523716	98	32553											
MRPL52	122704	broad.mit.edu	37	chr14	23299408	23299409	+	Frame_Shift_Ins	INS	-	G	G																															cacacaggcagggactggctINSgccaacccctccggctacgg																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr14:23299408_23299409insG	uc001wgw.3	+	3	132_133	c.102_103insG	c.(100-105)GCTGCCfs	p.A34fs	MRPL52_uc001wgx.3_Frame_Shift_Ins_p.A33fs|MRPL52_uc001wgy.3_5'UTR|MRPL52_uc001wgz.3_5'UTR|MRPL52_uc001wha.3_5'UTR|MRPL52_uc001whb.3_Frame_Shift_Ins_p.A34fs	NM_178336	NP_848026	Q86TS9	RM52_HUMAN	mitochondrial ribosomal protein L52 isoform a	34_35					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		AGGGACTGGCTGCCAACCCCTC	0.594													---	---	---								G	23299409	G	G	23299408	7	5	173	1	0	1	1	0	0	0	0	0	9869	1567	55	0	112	0	MRPL52	14	23299408	Frame_Shift_Ins	INS	-	TCGA-CV-5436-01A-01D-1512-08	2473584	23299408	84050132	99	32554											
JPH4	84502	broad.mit.edu	37	chr14	24045205	24045205	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccactcgcccgcgtacacCtctgtggccgagccctcgat	5	7	10	19	6	1	0	0	0	1	0	3	2	1	0	5	1	2	1	5	1	1	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr14:24045205C>G	uc001wkq.2	-	4	1758	c.840G>C	c.(838-840)GAG>GAC	p.E280D	JPH4_uc010tnr.1_5'Flank|JPH4_uc001wkr.2_Missense_Mutation_p.E280D|JPH4_uc001wks.2_Missense_Mutation_p.E280D	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	280	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		CCGCGTACACCTCTGTGGCCG	0.622													3	8					0	0	0	0	G	24045205	G	G	24045205	3	3	173	1	0	0	0	0	1	0	0	0	8002	680	24	4	1062	4	JPH4	14	24045205	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	745797	24045205	83304335	100	32555											
CDAN1	146059	broad.mit.edu	37	chr15	43027800	43027800	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caggttcatctgtgaggcttCctgtccggctggggaggggc	4	10	17	10	1	2	1	1	1	1	0	4	2	4	2	2	7	0	3	2	7	0	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr15:43027800C>T	uc001zql.2	-	4	968	c.851G>A	c.(850-852)GGA>GAA	p.G284E	CDAN1_uc001zqk.2_5'Flank|CDAN1_uc010bcx.1_5'Flank|uc001zqm.2_5'Flank	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	284						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		TGTGAGGCTTCCTGTCCGGCT	0.572													62	30					0	0	0	0	T	43027800	T	T	43027800	3	4	173	1	0	0	0	0	1	0	0	0	3069	855	30	2	2932	2	CDAN1	15	43027800	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08		43027800	59503592	101	32556											
WDR76	79968	broad.mit.edu	37	chr15	44143363	44143363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtctttacttctcacccGccaatccggcccacatactg	7	11	6	17	2	2	0	1	0	2	0	4	0	3	0	4	1	2	1	4	1	3	4			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr15:44143363G>A	uc001zti.1	+	9	1134	c.1111G>A	c.(1111-1113)GCC>ACC	p.A371T		NM_024908	NP_079184	Q9H967	WDR76_HUMAN	WD repeat domain 76	371	WD 2.										0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		CTTCTCACCCGCCAATCCGGC	0.458													9	193					0	0	0	0	A	44143363	A	A	44143363	3	1	173	1	0	0	0	0	1	0	0	0	17394	1087	38	1	1145	1	WDR76	15	44143363	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	1115563	44143363	58388029	102	32557											
CEP152	22995	broad.mit.edu	37	chr15	49059304	49059304	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtggtcttcctgagagtcaAttctagattatccttctctc	8	16	7	10	0	4	2	1	1	3	2	8	3	6	2	2	1	0	0	2	1	3	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr15:49059304A>G	uc001zwy.2	-	17	2267	c.2233T>C	c.(2233-2235)TTG>CTG	p.L745L	CEP152_uc001zwz.2_Silent_p.L745L|CEP152_uc001zxa.1_Silent_p.L652L	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	745	Potential.				centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CTGAGAGTCAATTCTAGATTA	0.423													178	103					0	0	0	0	G	49059304	G	G	49059304	2	3	173	1	0	0	0	0	0	0	0	1	3263	98	4	5		5	CEP152	15	49059304	Silent	SNP	A	TCGA-CV-5436-01A-01D-1512-08	4915941	49059304	53472088	103	32558											
C16orf73	254528	broad.mit.edu	37	chr16	1894871	1894871	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acggtcacttacaatttatgGattctttgaaataactgtca	13	15	6	7	1	3	1	2	1	1	0	3	2	3	2	0	2	2	0	0	2	5	6			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr16:1894871G>C	uc002cne.2	-	10	990	c.872C>G	c.(871-873)TCC>TGC	p.S291C	C16orf73_uc010uvq.1_Missense_Mutation_p.S291C|C16orf73_uc010uvr.1_Missense_Mutation_p.S84C	NM_152764	NP_689977	Q8N635	CP073_HUMAN	hypothetical protein LOC254528 isoform 2	291					meiosis	cytoplasm					0						ACAATTTATGGATTCTTTGAA	0.308													18	12					0	0	0	0	C	1894871	C	C	1894871	3	2	173	1	0	0	0	0	1	0	0	0	1838	1174	41	2	563	2	C16orf73	16	1894871	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08		1894871	88459882	104	32559											
SLC9A3R2	9351	broad.mit.edu	37	chr16	2086358	2086358	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctgagggagctgcgccctCggctctgccacctgcgaaag	6	6	13	16	3	1	1	0	1	1	0	2	3	1	2	4	2	4	2	4	2	1	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr16:2086358C>T	uc002coi.2	+	3	567	c.448C>T	c.(448-450)CGG>TGG	p.R150W	SLC9A3R2_uc002coj.2_Missense_Mutation_p.R150W|SLC9A3R2_uc002cok.2_Missense_Mutation_p.R39W	NM_001130012	NP_001123484	Q15599	NHRF2_HUMAN	solute carrier family 9 isoform 3 regulator 2	150	PDZ 2.				protein complex assembly	apical plasma membrane|endomembrane system|nucleus	beta-catenin binding|phosphatase binding|protein C-terminus binding|receptor binding			central_nervous_system(1)	1						GCTGCGCCCTCGGCTCTGCCA	0.667													10	11					0	0	0	0	T	2086358	T	T	2086358	3	4	173	1	0	0	0	0	1	0	0	0	14779	875	31	1	458	1	SLC9A3R2	16	2086358	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	191487	2086358	88268395	105	32560											
ITGAX	3687	broad.mit.edu	37	chr16	31391868	31391868	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagaagaaggtgtcggtcGtgagtgtggctgaaattacg	10	10	16	5	3	0	4	0	2	0	2	2	4	0	4	0	3	2	2	0	3	4	1	rs143612140		TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr16:31391868G>T	uc002ebu.1	+	28	3266	c.3199G>T	c.(3199-3201)GTG>TTG	p.V1067L	ITGAX_uc002ebt.2_Missense_Mutation_p.V1067L	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	1067	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGTGTCGGTCGTGAGTGTGGC	0.562													21	23					1.87028e-06	1.99347e-06	1	0	T	31391868	T	T	31391868	3	4	173	1	0	0	0	0	1	0	0	0	7928	1145	40	3	3309	3	ITGAX	16	31391868	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	29305510	31391868	58962885	106	32561											
IRX5	10265	broad.mit.edu	37	chr16	54967589	54967589	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cacgaactatggctccttcgGacaccttcatggccacccgg	8	8	9	16	3	1	0	1	0	0	0	3	2	2	1	4	4	1	1	4	4	2	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr16:54967589G>A	uc002ehv.2	+	3	1256	c.1256G>A	c.(1255-1257)GGA>GAA	p.G419E	IRX5_uc002ehw.2_Missense_Mutation_p.G353E	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	419					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						GGCTCCTTCGGACACCTTCAT	0.637													20	79					0	0	0	0	A	54967589	A	A	54967589	3	1	173	1	0	0	0	0	1	0	0	0	7886	1174	41	2	1266	2	IRX5	16	54967589	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	23575721	54967589	35387164	107	32562											
CNOT1	23019	broad.mit.edu	37	chr16	58557303	58557303	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttcttggatggcttccgtAttggcctctgcaaaaaggta	8	14	11	8	1	2	0	0	0	2	0	3	1	3	1	2	4	1	5	2	4	4	6			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr16:58557303A>T	uc002env.2	-	47	7181	c.6888T>A	c.(6886-6888)AAT>AAA	p.N2296K	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.N2291K|CNOT1_uc002ent.2_Missense_Mutation_p.N234K|CNOT1_uc010vik.1_Missense_Mutation_p.N1253K	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2296					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TGGCTTCCGTATTGGCCTCTG	0.413													35	164					0	0	0	0	T	58557303	T	T	58557303	3	4	173	1	0	0	0	0	1	0	0	0	3632	446	16	5	254	5	CNOT1	16	58557303	Missense_Mutation	SNP	A	TCGA-CV-5436-01A-01D-1512-08	3589714	58557303	31797450	108	32563											
CDH1	999	broad.mit.edu	37	chr16	68849489	68849489	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgtggtaccttttgaggtCtctctcaccacctccacagc	8	12	7	14	0	2	1	1	1	2	0	5	1	3	1	4	2	2	1	4	2	2	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr16:68849489C>T	uc002ewg.1	+	10	1516	c.1392C>T	c.(1390-1392)GTC>GTT	p.V464V	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Silent_p.V403V	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	464	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		CTTTTGAGGTCTCTCTCACCA	0.498			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				69	66					0	0	0	0	T	68849489	T	T	68849489	2	4	173	1	0	0	0	0	0	0	0	1	3110	900	32	2		2	CDH1	16	68849489	Silent	SNP	C	TCGA-CV-5436-01A-01D-1512-08	10292186	68849489	21505264	109	32564											
OR3A1	4994	broad.mit.edu	37	chr17	3195526	3195526	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcataggccatggcggtcagCaggaagcagtccactccaac	11	6	11	13	1	2	0	2	0	0	0	4	1	4	1	3	4	3	2	3	4	3	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr17:3195526C>T	uc002fvh.1	-	1	351	c.351G>A	c.(349-351)CTG>CTA	p.L117L		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						TGGCGGTCAGCAGGAAGCAGT	0.597													40	92					0	0	0	0	T	3195526	T	T	3195526	2	4	173	1	0	0	0	0	0	0	0	1	11091	697	25	4		4	OR3A1	17	3195526	Silent	SNP	C	TCGA-CV-5436-01A-01D-1512-08		3195526	77999684	110	32565											
TP53	7157	broad.mit.edu	37	chr17	7577141	7577141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcacctcaaagctgttccgtCccagtagattaccactactc	10	10	6	15	1	1	1	1	0	0	1	4	1	3	1	4	0	3	4	4	0	4	4			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr17:7577141C>T	uc002gim.2	-	8	991	c.797G>A	c.(796-798)GGA>GAA	p.G266E	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.G266E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G134E|TP53_uc010cng.1_Missense_Mutation_p.G134E|TP53_uc002gii.1_Missense_Mutation_p.G134E|TP53_uc010cnh.1_Missense_Mutation_p.G266E|TP53_uc010cni.1_Missense_Mutation_p.G266E|TP53_uc002gij.2_Missense_Mutation_p.G266E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	266	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G266E(45)|p.G266R(42)|p.G266V(32)|p.G266*(12)|p.0?(7)|p.G266fs*79(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266G(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.G266T(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.G266fs*9(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTGTTCCGTCCCAGTAGATT	0.517		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	38					0	0	0	0	T	7577141	T	T	7577141	3	4	173	1	0	0	0	0	1	0	0	0	16448	855	30	2	489	2	TP53	17	7577141	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	4381615	7577141	73618069	111	32566											
TP53	7157	broad.mit.edu	37	chr17	7579521	7579521	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatctggacctgggtcttCagtgaaccattgttcaatat	9	15	8	9	0	5	1	3	1	2	0	5	2	5	2	2	2	1	1	2	2	3	5			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr17:7579521C>A	uc002gim.2	-	4	360	c.166G>T	c.(166-168)GAA>TAA	p.E56*	TP53_uc002gig.1_Nonsense_Mutation_p.E56*|TP53_uc002gih.2_Nonsense_Mutation_p.E56*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.E56*|TP53_uc010cni.1_Nonsense_Mutation_p.E56*|TP53_uc002gij.2_Nonsense_Mutation_p.E56*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.E17*|TP53_uc010cnk.1_Nonsense_Mutation_p.E71*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	56	TADII.|Interaction with HRMT1L2.		E -> V (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.E56*(4)|p.E56K(3)|p.E51fs*59(1)|p.Q52fs*67(1)|p.D48fs*55(1)|p.E56fs*67(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.E56E(1)|p.E56V(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTGGGTCTTCAGTGAACCAT	0.597		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			85	197					9.01214e-43	1.04847e-42	1	0	A	7579521	A	A	7579521	4	1	173	1	0	0	0	0	0	1	0	0	16448	835	29	2	1136	2	TP53	17	7579521	Nonsense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	2380	7579521	73615689	112	32567											
TBC1D26	353149	broad.mit.edu	37	chr17	15641646	15641646	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcggtacggggccgggcgtGgtcacttttgctagatattg	5	11	17	8	4	1	1	1	0	0	1	1	1	1	1	1	6	2	2	1	6	3	6			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr17:15641646G>T	uc010cov.2	+	7	582	c.332G>T	c.(331-333)TGG>TTG	p.W111L	TBC1D26_uc010cou.1_Missense_Mutation_p.W111L|TBC1D26_uc002gpb.3_RNA	NM_178571	NP_848666	Q86UD7	TBC26_HUMAN	TBC1 domain family, member 26	111	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.078)		GGCCGGGCGTGGTCACTTTTG	0.507													5	92					7.07596e-05	7.40895e-05	1	0	T	15641646	T	T	15641646	3	4	173	1	0	0	0	0	1	0	0	0	15682	1357	47	4	350	4	TBC1D26	17	15641646	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	8062125	15641646	65553564	113	32568											
MYL4	4635	broad.mit.edu	37	chr17	45291173	45291173	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctccctacagatagacttCactgccgaccagattgaagg	11	8	8	14	1	1	4	1	1	0	3	2	5	2	4	4	1	2	0	4	1	3	4			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr17:45291173C>T	uc002ilg.2	+	3	272	c.144C>T	c.(142-144)TTC>TTT	p.F48F	MYL4_uc002ilh.2_Silent_p.F48F	NM_001002841	NP_001002841	P12829	MYL4_HUMAN	atrial/embryonic alkali myosin light chain	48					cardiac muscle contraction|muscle filament sliding|muscle organ development|positive regulation of ATPase activity|regulation of the force of heart contraction	A band|cytosol|muscle myosin complex	actin filament binding|actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			ovary(2)	2						AGATAGACTTCACTGCCGACC	0.403													84	150					0	0	0	0	T	45291173	T	T	45291173	2	4	173	1	0	0	0	0	0	0	0	1	10102	825	29	2		2	MYL4	17	45291173	Silent	SNP	C	TCGA-CV-5436-01A-01D-1512-08	29649527	45291173	35904037	114	32569											
DNAH17	8632	broad.mit.edu	37	chr17	76464798	76464798	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggggtcgcatggaggagatGatgttctccacctcgtcctc	6	11	13	11	2	1	2	0	1	1	1	6	4	2	3	3	4	0	2	3	4	0	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr17:76464798G>A	uc010dhp.1	-						DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGGAGGAGATGATGTTCTCCA	0.537													28	61					0	0	0	0	A	76464798	A	A	76464798	1	1	173	0	1	0	0	0	0	0	0	0	4623	1280	45	2		2	DNAH17	17	76464798	5'Flank	SNP	G	TCGA-CV-5436-01A-01D-1512-08	31173625	76464798	4730412	115	32570											
C18orf1	753	broad.mit.edu	37	chr18	13621261	13621262	+	Frame_Shift_Ins	INS	-	C	C																															gccggaggcgggaggacgggINSctgccgcaggtgagtaccct																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr18:13621261_13621262insC	uc002ksa.2	+	5	995_996	c.327_328insC	c.(325-330)GGGCTGfs	p.G109fs	C18orf1_uc002ksb.2_Frame_Shift_Ins_p.G109fs|C18orf1_uc002kse.2_Frame_Shift_Ins_p.G72fs|C18orf1_uc002ksf.2_Frame_Shift_Ins_p.G72fs|C18orf1_uc002ksg.1_Frame_Shift_Ins_p.G32fs|C18orf1_uc002ksh.1_Frame_Shift_Ins_p.G51fs|C18orf1_uc002ksi.1_Frame_Shift_Ins_p.G51fs	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	109_110	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		GGGAGGACGGGCTGCCGCAGGT	0.639													---	---	---								C	13621262	C	C	13621261	7	5	173	1	0	1	1	0	0	0	0	0	1903	1190	42	0	418	0	C18orf1	18	13621261	Frame_Shift_Ins	INS	-	TCGA-CV-5436-01A-01D-1512-08		13621261	64455987	116	32571											
SALL3	27164	broad.mit.edu	37	chr18	76754297	76754297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcggccagatccccaacaCgccgctgccggagggcttcc	6	4	14	17	4	0	1	0	0	0	1	2	2	2	2	6	4	2	2	6	4	1	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr18:76754297C>T	uc002lmt.2	+	2	2306	c.2306C>T	c.(2305-2307)ACG>ATG	p.T769M	SALL3_uc010dra.2_Missense_Mutation_p.T376M	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	769					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		ATCCCCAACACGCCGCTGCCG	0.637													17	28					0	0	0	0	T	76754297	T	T	76754297	3	4	173	1	0	0	0	0	1	0	0	0	13877	536	19	1	2312	1	SALL3	18	76754297	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	63133036	76754297	1322951	117	32572											
ANGPTL4	51129	broad.mit.edu	37	chr19	8435950	8435950	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttctgggcagatggaggctgGacagtaattcagaggcgcca	10	8	15	8	1	2	2	1	0	1	2	2	4	2	4	1	5	0	3	1	5	1	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr19:8435950G>C	uc002mjq.1	+	5	867	c.672G>C	c.(670-672)TGG>TGC	p.W224C	ANGPTL4_uc002mjr.1_Missense_Mutation_p.W186C|ANGPTL4_uc010xkc.1_Missense_Mutation_p.W57C	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	224	Fibrinogen C-terminal.				angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						ATGGAGGCTGGACAGTAATTC	0.587													10	16					0	0	0	0	C	8435950	C	C	8435950	3	2	173	1	0	0	0	0	1	0	0	0	616	1183	41	2	690	2	ANGPTL4	19	8435950	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08		8435950	50693033	118	32573											
ATG4D	84971	broad.mit.edu	37	chr19	10655726	10655726	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcctgggggctgcctgacctCggactgtggctgggggtgca	3	9	18	11	1	0	1	0	1	0	0	2	2	1	2	3	6	2	3	3	6	0	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr19:10655726C>G	uc002mov.2	+	3	533	c.413C>G	c.(412-414)TCG>TGG	p.S138W	ATG4D_uc010xlg.1_Missense_Mutation_p.S161W|ATG4D_uc010xlh.1_Missense_Mutation_p.S75W|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_RNA|ATG4D_uc010dxj.2_5'UTR	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	138					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			TGCCTGACCTCGGACTGTGGC	0.632													18	266					0	0	0	0	G	10655726	G	G	10655726	3	3	173	1	0	0	0	0	1	0	0	0	1101	893	31	3	423	3	ATG4D	19	10655726	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	2219776	10655726	48473257	119	32574											
CPAMD8	27151	broad.mit.edu	37	chr19	17088291	17088291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggaccatgctgggggtcaCggccagatgaagagaggtca	10	5	18	8	1	2	3	2	1	0	2	2	5	2	4	2	6	1	1	2	6	1	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr19:17088291C>T	uc002nfb.2	-	15	1818	c.1786G>A	c.(1786-1788)GTG>ATG	p.V596M		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	549						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CTGGGGGTCACGGCCAGATGA	0.592													29	51					0	0	0	0	T	17088291	T	T	17088291	3	4	173	1	0	0	0	0	1	0	0	0	3810	536	19	1	4124	1	CPAMD8	19	17088291	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	6432565	17088291	42040692	120	32575											
NCAN	1463	broad.mit.edu	37	chr19	19338359	19338359	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggtcccaaagagtggatgCtaccacaccccacccccatc	10	6	8	17	0	0	1	0	0	0	1	2	2	1	2	6	2	2	1	6	2	2	1			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr19:19338359C>G	uc002nlz.2	+	8	2029	c.1930C>G	c.(1930-1932)CTA>GTA	p.L644V	NCAN_uc010ecc.1_Missense_Mutation_p.L208V	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	644					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			AGAGTGGATGCTACCACACCC	0.637													9	73					0	0	0	0	G	19338359	G	G	19338359	3	3	173	1	0	0	0	0	1	0	0	0	10258	796	28	4	1956	4	NCAN	19	19338359	Missense_Mutation	SNP	C	TCGA-CV-5436-01A-01D-1512-08	2250068	19338359	39790624	121	32576											
ZSCAN22	342945	broad.mit.edu	37	chr19	58850657	58850657	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtcgtagctcagccctgatgGttcacttgcggatccacatc	7	11	10	13	2	2	1	2	1	0	0	5	2	3	2	2	2	3	3	2	2	1	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr19:58850657G>A	uc002qsc.2	+	3	1588	c.1441G>A	c.(1441-1443)GTT>ATT	p.V481I	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	481	C2H2-type 8.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		AGCCCTGATGGTTCACTTGCG	0.587													28	44					0	0	0	0	A	58850657	A	A	58850657	3	1	173	1	0	0	0	0	1	0	0	0	18301	1261	44	4	1447	4	ZSCAN22	19	58850657	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	39512298	58850657	278326	122	32577											
FOXS1	2307	broad.mit.edu	37	chr20	30432595	30432595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaaattcagtgcctgcagccGacactggtagctgctcccga	10	8	10	13	2	1	0	1	0	0	0	2	2	2	0	3	1	5	4	3	1	3	2			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr20:30432595G>A	uc002wwt.1	-	1	826	c.751C>T	c.(751-753)CGG>TGG	p.R251W		NM_004118	NP_004109	O43638	FOXS1_HUMAN	forkhead box S1	251					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1						GCCTGCAGCCGACACTGGTAG	0.617													13	47					0	0	0	0	A	30432595	A	A	30432595	3	1	173	1	0	0	0	0	1	0	0	0	6069	1057	37	1	245	1	FOXS1	20	30432595	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08		30432595	32592925	123	32578											
ARFGEF2	10564	broad.mit.edu	37	chr20	47630398	47630398	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcatgtttgagatcatgaaGagctatggccacacctttga	11	12	10	8	0	2	4	2	3	0	2	2	5	2	4	2	1	1	2	2	1	2	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr20:47630398G>C	uc002xtx.3	+	30	4232	c.4080G>C	c.(4078-4080)AAG>AAC	p.K1360N	ARFGEF2_uc010zyf.1_Missense_Mutation_p.K653N	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1360					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AGATCATGAAGAGCTATGGCC	0.473													42	153					0	0	0	0	C	47630398	C	C	47630398	3	2	173	1	0	0	0	0	1	0	0	0	853	933	33	2	4198	2	ARFGEF2	20	47630398	Missense_Mutation	SNP	G	TCGA-CV-5436-01A-01D-1512-08	17197803	47630398	15395122	124	32579											
GNAZ	2781	broad.mit.edu	37	chr22	23438215	23438215	+	Frame_Shift_Del	DEL	G	-	-																															gtgcagctctttgcgctgacGggccccgctgagagcaaggg																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr22:23438215delG	uc002zwu.1	+	2	870	c.333delG	c.(331-333)ACGfs	p.T111fs	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	111						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		TTGCGCTGACGGGCCCCGCTG	0.687													---	---	---								-	23438215	-	-	23438215	7	5	173	1	0	1	0	1	0	0	0	0	6551	1103	39	0	335	0	GNAZ	22	23438215	Frame_Shift_Del	DEL	G	TCGA-CV-5436-01A-01D-1512-08		23438215	27866351	125	32580											
GGT1	2678	broad.mit.edu	37	chr22	25016313	25016313	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggggctgtcggtggcggTgcctggggagatccgaggct	4	7	22	8	3	0	1	0	0	0	1	2	3	1	1	2	9	1	2	2	9	0	0			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	fc3c7836-b5b2-453e-880f-5dee65b9f104	g.chr22:25016313T>A	uc003aan.1	+	8	888	c.401T>A	c.(400-402)GTG>GAG	p.V134E	GGT1_uc003aas.1_Missense_Mutation_p.V134E|GGT1_uc003aat.1_Missense_Mutation_p.V134E|GGT1_uc003aau.1_Missense_Mutation_p.V134E|GGT1_uc003aav.1_Missense_Mutation_p.V134E|GGT1_uc003aaw.1_Missense_Mutation_p.V134E|GGT1_uc003aax.1_Missense_Mutation_p.V134E	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	134	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	TCGGTGGCGGTGCCTGGGGAG	0.682													5	40					0	0	0	0	A	25016313	A	A	25016313	3	1	173	1	0	0	0	0	1	0	0	0	6398	1696	59	5	415	5	GGT1	22	25016313	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	1578098	25016313	26288253	126	32581											
PLA2G3	50487	broad.mit.edu	37	chr22	31534395	31534395	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attctgtaggcattgctgaaAcctgccccagaacagatacc	12	9	8	12	0	1	3	0	1	1	2	1	3	1	3	4	1	5	3	4	1	4	4			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr22:31534395A>G	uc003aka.2	-	3	778	c.649T>C	c.(649-651)TTT>CTT	p.F217L		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	217	Phospholipase A2-like.				cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						CATTGCTGAAACCTGCCCCAG	0.483													11	51					0	0	0	0	G	31534395	G	G	31534395	3	3	173	1	0	0	0	0	1	0	0	0	12055	57	2	5	900	5	PLA2G3	22	31534395	Missense_Mutation	SNP	A	TCGA-CV-5436-01A-01D-1512-08	6518082	31534395	19770171	127	32582											
TMPRSS6	164656	broad.mit.edu	37	chr22	37491963	37491963	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacccaggatcactaggcccTcggggtccacttcgtactcg	7	8	11	15	3	1	0	1	0	0	0	5	2	2	1	3	4	1	1	3	4	2	3			TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	cebe8f62-3438-4364-8b1d-730df24ba748	g.chr22:37491963T>C	uc003aqs.1	-	5	713	c.599A>G	c.(598-600)GAG>GGG	p.E200G	TMPRSS6_uc003aqt.1_Missense_Mutation_p.E191G|TMPRSS6_uc003aqu.2_Missense_Mutation_p.E191G	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	200	Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						CACTAGGCCCTCGGGGTCCAC	0.647													36	81					0	0	0	0	C	37491963	C	C	37491963	3	2	173	1	0	0	0	0	1	0	0	0	16317	1551	54	5	1892	5	TMPRSS6	22	37491963	Missense_Mutation	SNP	T	TCGA-CV-5436-01A-01D-1512-08	5957568	37491963	13812603	128	32583											
NAP1L2	4674	broad.mit.edu	37	chrX	72433664	72433666	+	In_Frame_Del	DEL	TCC	-	-																															ctccagtagcctcaatgtcgTcctcctcctcctcctcctcc																										TCGA-CV-5436-01A-01D-1512-08	TCGA-CV-5436-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	34dc613e-e4b4-4897-ac4b-13ff46e46d7e	fc3c7836-b5b2-453e-880f-5dee65b9f104	g.chrX:72433664_72433666delTCC	uc004ebi.2	-	1	1019_1021	c.663_665delGGA	c.(661-666)GAGGAC>GAC	p.E221del	NAP1L2_uc011mqj.1_In_Frame_Del_p.E79del	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	221	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					CTCAATGTCGtcctcctcctcct	0.33													---	---	---								-	72433666	-	-	72433664	7	5	173	1	0	1	0	1	0	0	0	0	10210	1667	58	0	721	0	NAP1L2	23	72433664	In_Frame_Del	DEL	TCC	TCGA-CV-5436-01A-01D-1512-08		72433664	82836896	129	32584											
TAS1R3	83756	broad.mit.edu	37	chr1	1269065	1269065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggggctgttcgttcaccatCgggacagcccactggttcag	6	10	13	12	2	2	0	2	0	0	0	4	1	2	1	2	4	1	4	2	4	0	3	rs149144084		TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:1269065C>T	uc010nyk.1	+	6	1780	c.1780C>T	c.(1780-1782)CGG>TGG	p.R594W		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	594	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CGTTCACCATCGGGACAGCCC	0.458													4	22					0	0	0	0	T	1269065	T	T	1269065	3	4	174	1	0	0	0	0	1	0	0	0	15630	875	31	1	1802	1	TAS1R3	1	1269065	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08		1269065	247981556	1	32585											
SLC45A1	50651	broad.mit.edu	37	chr1	8386047	8386047	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccacgcctacatgatggaCgtgtgcagccccgcagacca	10	5	11	15	3	0	2	0	1	0	1	0	3	0	3	5	1	4	2	5	1	1	1	rs144175783		TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:8386047C>A	uc001apb.2	+	3	660	c.660C>A	c.(658-660)GAC>GAA	p.D220E		NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	220					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		ACATGATGGACGTGTGCAGCC	0.657													28	42					1.26612e-14	1.57038e-14	1	0	A	8386047	A	A	8386047	3	1	174	1	0	0	0	0	1	0	0	0	14704	535	19	3	670	3	SLC45A1	1	8386047	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	7116982	8386047	240864574	2	32586											
TCEB3	6924	broad.mit.edu	37	chr1	24077469	24077469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacggggagccgatcctataGccctgaccacaggcagaaga	12	4	12	13	2	0	3	0	1	0	2	1	5	1	4	4	3	2	1	4	3	3	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:24077469G>A	uc001bho.2	+	4	512	c.452G>A	c.(451-453)AGC>AAC	p.S151N		NM_003198	NP_003189	Q14241	ELOA1_HUMAN	elongin A	151					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		CGATCCTATAGCCCTGACCAC	0.552													13	27					0	0	0	0	A	24077469	A	A	24077469	3	1	174	1	0	0	0	0	1	0	0	0	15747	971	34	4	466	4	TCEB3	1	24077469	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	15691422	24077469	225173152	3	32587											
MACF1	23499	broad.mit.edu	37	chr1	39759235	39759235	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaaggaggaggaggaactaGcatatgactggagtgacaac	16	5	15	5	0	0	3	0	2	0	1	0	8	0	8	0	5	3	1	0	5	5	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:39759235G>A	uc010ois.1	+	19	2318	c.2113G>A	c.(2113-2115)GCA>ACA	p.A705T	MACF1_uc001cda.1_Missense_Mutation_p.A613T	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	705					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGAGGAACTAGCATATGACTG	0.443													12	51					0	0	0	0	A	39759235	A	A	39759235	3	1	174	1	0	0	0	0	1	0	0	0	9195	971	34	4	2179	4	MACF1	1	39759235	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	15681766	39759235	209491386	4	32588											
KLF17	128209	broad.mit.edu	37	chr1	44596220	44596220	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcaactgggaaagttgttCatggtctttcttccgttctg	6	17	10	8	1	4	0	1	0	3	0	5	1	5	1	1	2	2	4	1	2	2	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:44596220C>G	uc001clp.2	+	3	1020	c.962C>G	c.(961-963)TCA>TGA	p.S321*		NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	321	C2H2-type 2.				regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					GAAAGTTGTTCATGGTCTTTC	0.463													3	76					0	0	0	0	G	44596220	G	G	44596220	4	3	174	1	0	0	0	0	0	1	0	0	8384	838	29	2	972	2	KLF17	1	44596220	Nonsense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	4836985	44596220	204654401	5	32589											
FCRL1	115350	broad.mit.edu	37	chr1	157773638	157773638	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accccactgacactcactgtGcacatttatctgggatctcc	9	11	6	15	0	3	1	1	1	2	0	4	2	3	2	3	1	1	1	3	1	1	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:157773638G>T	uc001frg.2	-	3	429	c.316C>A	c.(316-318)CAC>AAC	p.H106N	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Missense_Mutation_p.H106N|FCRL1_uc001fri.2_Missense_Mutation_p.H106N|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	106	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CACTCACTGTGCACATTTATC	0.522													5	49					0.000602214	0.000629767	1	0	T	157773638	T	T	157773638	3	4	174	1	0	0	0	0	1	0	0	0	5826	1319	46	4	1075	4	FCRL1	1	157773638	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	113177418	157773638	91476983	6	32590											
CD84	8832	broad.mit.edu	37	chr1	160523210	160523210	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacaaaaacactgaagacaGaatgagaacaagcagaaaga	24	2	9	6	0	0	6	0	2	0	5	0	8	0	6	0	0	4	1	0	0	8	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:160523210G>A	uc001fwh.3	-	4	742	c.718C>T	c.(718-720)CTG>TTG	p.L240L	CD84_uc001fwf.3_Silent_p.L240L|CD84_uc001fwg.3_Silent_p.L240L|CD84_uc009wtn.2_Silent_p.L240L|CD84_uc001fwi.3_Silent_p.L126L|CD84_uc001fwj.2_Silent_p.L240L	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	240	Helical; (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ACTGAAGACAGAATGAGAACA	0.468													4	38					0	0	0	0	A	160523210	A	A	160523210	2	1	174	1	0	0	0	0	0	0	0	1	3057	933	33	2		2	CD84	1	160523210	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	2749572	160523210	88727411	7	32591											
POGK	57645	broad.mit.edu	37	chr1	166818449	166818449	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctgatggtagtggaataTgctgagagtaccaacaactg	14	9	12	6	0	0	2	0	2	0	1	0	4	0	3	1	2	5	4	1	2	7	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:166818449T>C	uc001gdt.1	+	5	753	c.633T>C	c.(631-633)TAT>TAC	p.Y211Y	POGK_uc010ple.1_Silent_p.Y126Y|POGK_uc010plf.1_Silent_p.Y93Y	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	211					multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						TAGTGGAATATGCTGAGAGTA	0.527													21	28					0	0	0	0	C	166818449	C	C	166818449	2	2	174	1	0	0	0	0	0	0	0	1	12240	1471	51	5		5	POGK	1	166818449	Silent	SNP	T	TCGA-CV-5439-01A-01D-1683-08	6295239	166818449	82432172	8	32592											
FAM129A	116496	broad.mit.edu	37	chr1	184764621	184764621	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctttcttcacagttgtcgggGtggatggcagctgcctgact	5	13	13	10	1	2	1	1	1	1	0	3	2	2	2	1	4	2	3	1	4	0	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:184764621G>A	uc001gra.2	-	14	2471	c.2277C>T	c.(2275-2277)CAC>CAT	p.H759H	FAM129A_uc001grb.1_Intron	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	759	Glu-rich.				negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						AGTTGTCGGGGTGGATGGCAG	0.562													70	159					0	0	0	0	A	184764621	A	A	184764621	2	1	174	1	0	0	0	0	0	0	0	1	5464	1252	44	4		4	FAM129A	1	184764621	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	17946172	184764621	64486000	9	32593											
NAV1	89796	broad.mit.edu	37	chr1	201618224	201618224	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagacgctgtccaagtcggAgcactcgctcttccaggcca	9	7	10	15	3	1	1	0	0	1	1	5	2	3	2	3	2	1	3	3	2	2	1			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:201618224A>G	uc001gwu.2	+	1	775	c.428A>G	c.(427-429)GAG>GGG	p.E143G		NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	143					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						TCCAAGTCGGAGCACTCGCTC	0.672													5	10					0	0	0	0	G	201618224	G	G	201618224	3	3	174	1	0	0	0	0	1	0	0	0	10236	304	11	5	430	5	NAV1	1	201618224	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	16853603	201618224	47632397	10	32594											
LAMB3	3914	broad.mit.edu	37	chr1	209804074	209804074	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgctggcagacacagacatCgtggacctgggagggggacc	9	5	17	10	1	0	2	0	0	0	2	1	5	0	5	2	5	1	2	2	5	0	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:209804074C>T	uc001hhg.2	-	8	1219	c.829G>A	c.(829-831)GAT>AAT	p.D277N	LAMB3_uc009xco.2_Missense_Mutation_p.D277N|LAMB3_uc001hhh.2_Missense_Mutation_p.D277N|LAMB3_uc010psl.1_RNA|LAMB3_uc009xcp.1_Missense_Mutation_p.D213N	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	277	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		ACACAGACATCGTGGACCTGG	0.562													4	36					0	0	0	0	T	209804074	T	T	209804074	3	4	174	1	0	0	0	0	1	0	0	0	8652	884	31	1	2749	1	LAMB3	1	209804074	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	8185850	209804074	39446547	11	32595											
USH2A	7399	broad.mit.edu	37	chr1	215847915	215847915	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcaatgttggagagtccatGttctctggcagggcctccat	7	12	12	10	0	1	1	0	0	1	1	4	2	3	1	3	3	1	4	3	3	1	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:215847915G>A	uc001hku.1	-	63	13725	c.13338C>T	c.(13336-13338)AAC>AAT	p.N4446N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4446	Fibronectin type-III 30.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAGAGTCCATGTTCTCTGGCA	0.463										HNSCC(13;0.011)			41	31					0	0	0	0	A	215847915	A	A	215847915	2	1	174	1	0	0	0	0	0	0	0	1	17104	1368	48	4		4	USH2A	1	215847915	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	6043841	215847915	33402706	12	32596											
ZNF695	57116	broad.mit.edu	37	chr1	247162685	247162685	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctctgtgttcacgttcCagggctctttccttgcctcc	2	17	7	15	1	4	0	1	0	3	0	8	0	7	0	4	1	1	3	4	1	0	5			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr1:247162685C>A	uc009xgu.2	-	3	369	c.224G>T	c.(223-225)TGG>TTG	p.W75L	ZNF695_uc001ica.2_RNA|ZNF695_uc001icb.1_RNA|ZNF695_uc009xgt.1_RNA|ZNF695_uc001ibx.2_Missense_Mutation_p.W75L|ZNF695_uc001iby.2_RNA|ZNF695_uc001icc.2_Missense_Mutation_p.W63L	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	75	KRAB.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GTTCACGTTCCAGGGCTCTTT	0.468													8	31					5.4927e-09	6.27738e-09	1	0	A	247162685	A	A	247162685	3	1	174	1	0	0	0	0	1	0	0	0	18165	595	21	4	1331	4	ZNF695	1	247162685	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	31314770	247162685	2087936	13	32597											
TTC15	51112	broad.mit.edu	37	chr2	3469400	3469400	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgtggaggcgtatcattcGgttatcaagtattacccaga	10	11	11	9	3	2	1	2	0	0	1	3	2	2	2	2	3	1	3	2	3	5	5			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:3469400G>T	uc002qxm.1	+	9	1916	c.1710G>T	c.(1708-1710)TCG>TCT	p.S570S	TTC15_uc002qxn.1_Silent_p.S570S|TTC15_uc010ewm.1_Silent_p.S576S	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	570	TPR 1.						binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		CGTATCATTCGGTTATCAAGT	0.532													24	51					4.7796e-09	5.5017e-09	1	0	T	3469400	T	T	3469400	2	4	174	1	0	0	0	0	0	0	0	1	16750	1103	39	3		3	TTC15	2	3469400	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08		3469400	239729973	14	32598											
APOB	338	broad.mit.edu	37	chr2	21234136	21234136	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccagcgatgtctgtgttGagccgatggctaaactccac	9	9	11	12	2	1	1	0	1	1	0	2	3	2	1	3	1	4	2	3	1	2	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:21234136G>T	uc002red.2	-	26	5732	c.5604C>A	c.(5602-5604)CTC>CTA	p.L1868L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1868					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGTCTGTGTTGAGCCGATGGC	0.458													29	83					3.73988e-18	4.78705e-18	1	0	T	21234136	T	T	21234136	2	4	174	1	0	0	0	0	0	0	0	1	785	1277	45	2		2	APOB	2	21234136	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	17764736	21234136	221965237	15	32599											
APOB	338	broad.mit.edu	37	chr2	21255430	21255430	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actgaggctgtccacactgaAccaaggcttgtaaagtgatg	12	9	11	9	0	0	3	0	3	0	0	1	3	1	3	2	2	1	3	2	2	4	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:21255430A>G	uc002red.2	-	10	1276	c.1148T>C	c.(1147-1149)GTT>GCT	p.V383A		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	383	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCCACACTGAACCAAGGCTTG	0.502													11	21					0	0	0	0	G	21255430	G	G	21255430	3	3	174	1	0	0	0	0	1	0	0	0	785	43	2	5	12623	5	APOB	2	21255430	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	21294	21255430	221943943	16	32600											
BRE	9577	broad.mit.edu	37	chr2	28117398	28117398	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattctttccttctgctttcAgtggtgatttacaagtcaag	8	18	7	8	0	4	1	2	1	2	0	5	1	5	1	1	1	2	1	1	1	4	7			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:28117398A>T	uc002rlr.2	+	3	295	c.-23_splice	c.e3-2		BRE_uc002rlp.1_Splice_Site|BRE_uc002rlq.2_Splice_Site|BRE_uc002rls.2_Splice_Site|BRE_uc002rlt.2_Splice_Site|BRE_uc002rlu.2_Splice_Site	NM_199194	NP_954664	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A						apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			lung(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					TTCTGCTTTCAGTGGTGATTT	0.438													44	107					0	0	0	0	T	28117398	T	T	28117398	5	4	174	1	0	0	0	0	0	0	1	0	1514	202	7	5		5	BRE	2	28117398	Splice_Site	SNP	A	TCGA-CV-5439-01A-01D-1683-08	6861968	28117398	215081975	17	32601											
POLR1A	25885	broad.mit.edu	37	chr2	86327213	86327213	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaatctgcagggcccaaagCtaaatcgtacaggccgtttg	11	8	12	10	2	1	0	0	0	1	0	2	1	1	1	2	3	3	4	2	3	5	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:86327213C>T	uc002sqs.2	-	2	539	c.160G>A	c.(160-162)GCT>ACT	p.A54T	POLR1A_uc002sqv.2_Missense_Mutation_p.A54T	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	54					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GGGCCCAAAGCTAAATCGTAC	0.517													14	30					0	0	0	0	T	86327213	T	T	86327213	3	4	174	1	0	0	0	0	1	0	0	0	12264	797	28	4	5134	4	POLR1A	2	86327213	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	58209815	86327213	156872160	18	32602											
FABP1	2168	broad.mit.edu	37	chr2	88427526	88427526	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctgcagttggtacttgccgGagaaactcatggtggcaata	10	11	12	8	1	2	1	1	0	1	1	2	2	2	1	1	4	4	4	1	4	4	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:88427526G>A	uc002sst.1	-	1	53	c.11C>T	c.(10-12)TCC>TTC	p.S4F	FABP1_uc002ssu.2_Missense_Mutation_p.S4F	NM_001443	NP_001434	P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	4					organ morphogenesis						0						GTACTTGCCGGAGAAACTCAT	0.537													31	51					0	0	0	0	A	88427526	A	A	88427526	3	1	174	1	0	0	0	0	1	0	0	0	5383	1174	41	2	388	2	FABP1	2	88427526	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	2100313	88427526	154771847	19	32603											
AFF3	3899	broad.mit.edu	37	chr2	100203709	100203709	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttctctccctgggacttcTtgatctccctgtagtcgtct	3	17	7	14	1	4	1	0	1	4	0	8	2	5	2	2	1	0	1	2	1	1	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:100203709T>C	uc002tag.2	-	15	2734	c.2498A>G	c.(2497-2499)AAG>AGG	p.K833R	AFF3_uc002taf.2_Missense_Mutation_p.K858R|AFF3_uc010fiq.1_Missense_Mutation_p.K833R|AFF3_uc010yvr.1_Missense_Mutation_p.K986R|AFF3_uc002tah.1_Missense_Mutation_p.K858R	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	833					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CTGGGACTTCTTGATCTCCCT	0.463													50	110					0	0	0	0	C	100203709	C	C	100203709	3	2	174	1	0	0	0	0	1	0	0	0	358	1609	56	5	1222	5	AFF3	2	100203709	Missense_Mutation	SNP	T	TCGA-CV-5439-01A-01D-1683-08	11776183	100203709	142995664	20	32604											
CNTNAP5	129684	broad.mit.edu	37	chr2	125284860	125284860	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttttttctctgtcccacAgggtgccccgacaatctcac	7	13	6	15	1	3	0	1	0	3	0	6	1	4	0	3	1	1	0	3	1	1	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:125284860A>G	uc002tno.2	+	10	1839	c.1475_splice	c.e10-2	p.G492_splice	CNTNAP5_uc010flu.2_Splice_Site_p.G493_splice	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCTGTCCCACAGGGTGCCCCG	0.453													3	21					0	0	0	0	G	125284860	G	G	125284860	5	3	174	1	0	0	0	0	0	0	1	0	3665	202	7	5	1511	5	CNTNAP5	2	125284860	Splice_Site	SNP	A	TCGA-CV-5439-01A-01D-1683-08	25081151	125284860	117914513	21	32605											
YSK4	80122	broad.mit.edu	37	chr2	135756434	135756434	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcacattgcagagctcccTggaactttcctctttttgca	7	15	7	12	0	2	1	1	0	1	1	4	2	4	2	2	1	4	4	2	1	1	5			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:135756434T>A	uc002tue.1	-	5	479	c.448A>T	c.(448-450)AGG>TGG	p.R150W	YSK4_uc010fne.1_Missense_Mutation_p.R122W|YSK4_uc002tuf.1_Missense_Mutation_p.R150W|YSK4_uc010fnc.1_Missense_Mutation_p.R150W|YSK4_uc010fnd.1_Intron|YSK4_uc010zbg.1_Missense_Mutation_p.R150W|YSK4_uc002tui.3_Missense_Mutation_p.R167W	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	150							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CAGAGCTCCCTGGAACTTTCC	0.428													22	37					0	0	0	0	A	135756434	A	A	135756434	3	1	174	1	0	0	0	0	1	0	0	0	17563	1579	55	5	3562	5	YSK4	2	135756434	Missense_Mutation	SNP	T	TCGA-CV-5439-01A-01D-1683-08	10471574	135756434	107442939	22	32606											
ABCA12	26154	broad.mit.edu	37	chr2	215840653	215840653	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggataacctgagcaatgagaCctttccagttcctgcgggtg	9	10	12	10	1	0	2	0	2	0	1	2	4	2	3	4	2	3	2	4	2	2	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:215840653C>T	uc002vew.2	-	34	5457	c.5237G>A	c.(5236-5238)GGT>GAT	p.G1746D	ABCA12_uc002vev.2_Missense_Mutation_p.G1428D|ABCA12_uc010zjn.1_Missense_Mutation_p.G673D	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1746					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGCAATGAGACCTTTCCAGTT	0.498													14	30					0	0	0	0	T	215840653	T	T	215840653	3	4	174	1	0	0	0	0	1	0	0	0	30	507	18	4	2630	4	ABCA12	2	215840653	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	80084219	215840653	27358720	23	32607											
PLCD4	84812	broad.mit.edu	37	chr2	219494358	219494358	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcctgttcaaagatgtcgTggccacagtagcacagtatg	11	10	10	10	1	1	1	1	0	0	1	3	1	2	1	2	1	1	4	2	1	3	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr2:219494358T>C	uc002vij.1	+	8	1286	c.1091T>C	c.(1090-1092)GTG>GCG	p.V364A	PLCD4_uc002vik.1_3'UTR|PLCD4_uc010zkk.1_Intron	NM_032726	NP_116115	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	364	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)	3		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AAAGATGTCGTGGCCACAGTA	0.592													10	22					0	0	0	0	C	219494358	C	C	219494358	3	2	174	1	0	0	0	0	1	0	0	0	12088	1696	59	5	1117	5	PLCD4	2	219494358	Missense_Mutation	SNP	T	TCGA-CV-5439-01A-01D-1683-08	3653705	219494358	23705015	24	32608											
TRANK1	9881	broad.mit.edu	37	chr3	36897366	36897366	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccaactaggaatggttgActcttcctgtgcagaccatc	9	12	9	11	0	1	2	0	1	1	1	3	3	2	3	3	2	3	2	3	2	3	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr3:36897366A>T	uc003cgj.2	-	3	2367	c.2065T>A	c.(2065-2067)TCA>ACA	p.S689T		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1239					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GGAATGGTTGACTCTTCCTGT	0.473													46	43					0	0	0	0	T	36897366	T	T	36897366	3	4	174	1	0	0	0	0	1	0	0	0	16521	275	10	5	5110	5	TRANK1	3	36897366	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08		36897366	161125064	25	32609											
HYAL1	3373	broad.mit.edu	37	chr3	50338477	50338477	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccagctgccccctgggccGcactctcccccaggctgtgc	3	7	10	21	1	1	0	0	0	1	0	3	0	2	0	6	2	3	3	6	2	0	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr3:50338477G>A	uc003czp.2	-	3	1064	c.932C>T	c.(931-933)GCG>GTG	p.A311V	HYAL3_uc003czc.1_5'Flank|HYAL3_uc003czd.1_5'Flank|HYAL3_uc003cze.1_5'Flank|HYAL3_uc003czf.1_5'Flank|HYAL3_uc003czg.1_5'Flank|NAT6_uc003czi.2_5'Flank|NAT6_uc003czj.2_5'Flank|NAT6_uc003czk.3_5'Flank|NAT6_uc003czl.1_5'Flank|HYAL1_uc003czm.2_Missense_Mutation_p.A129V|HYAL1_uc003czo.2_Missense_Mutation_p.A52V|HYAL1_uc003czq.2_Intron|HYAL1_uc003czr.2_Missense_Mutation_p.A311V|HYAL1_uc003czn.2_5'UTR|HYAL1_uc003czs.2_Missense_Mutation_p.A311V|HYAL1_uc003czt.2_Missense_Mutation_p.A311V	NM_033159	NP_149349	Q12794	HYAL1_HUMAN	hyaluronoglucosaminidase 1 isoform 1	311						extracellular space|lysosome	hyalurononglucosaminidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)	Hyaluronidase(DB00070)	CCCCTGGGCCGCACTCTCCCC	0.627													3	26					0	0	0	0	A	50338477	A	A	50338477	3	1	174	1	0	0	0	0	1	0	0	0	7502	1087	38	1	383	1	HYAL1	3	50338477	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	13441111	50338477	147683953	26	32610											
SAMD7	344658	broad.mit.edu	37	chr3	169642876	169642876	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttaccacctgaatccataaAggcagtggccagaaggaatg	14	8	10	9	0	0	2	0	1	0	1	1	3	1	3	4	3	1	1	4	3	6	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr3:169642876A>T	uc003fgd.2	+	5	509	c.242A>T	c.(241-243)AAG>ATG	p.K81M	SAMD7_uc003fge.2_Missense_Mutation_p.K81M|SAMD7_uc011bpo.1_Translation_Start_Site	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	81										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GAATCCATAAAGGCAGTGGCC	0.343													5	66					0	0	0	0	T	169642876	T	T	169642876	3	4	174	1	0	0	0	0	1	0	0	0	13889	72	3	5	252	5	SAMD7	3	169642876	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	119304399	169642876	28379554	27	32611											
TNIK	23043	broad.mit.edu	37	chr3	170819325	170819325	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctcgctactttctgacTcctcactggaggaggagtaa	8	12	9	12	1	2	1	1	1	1	0	5	4	4	4	2	3	1	2	2	3	2	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr3:170819325T>C	uc003fhh.2	-	22	2849	c.2504A>G	c.(2503-2505)GAG>GGG	p.E835G	TNIK_uc003fhi.2_Missense_Mutation_p.E780G|TNIK_uc003fhj.2_Missense_Mutation_p.E806G|TNIK_uc003fhk.2_Missense_Mutation_p.E827G|TNIK_uc003fhl.2_Missense_Mutation_p.E751G|TNIK_uc003fhm.2_Missense_Mutation_p.E772G|TNIK_uc003fhn.2_Missense_Mutation_p.E798G|TNIK_uc003fho.2_Missense_Mutation_p.E743G|TNIK_uc003fhg.2_Missense_Mutation_p.E13G	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	835	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			ACTTTCTGACTCCTCACTGGA	0.493													128	144					0	0	0	0	C	170819325	C	C	170819325	3	2	174	1	0	0	0	0	1	0	0	0	16379	1551	54	5	1626	5	TNIK	3	170819325	Missense_Mutation	SNP	T	TCGA-CV-5439-01A-01D-1683-08	1176449	170819325	27203105	28	32612											
JAKMIP1	152789	broad.mit.edu	37	chr4	6082004	6082004	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggtcattcaaggaggtatgCcgcttcagagacgcctgcgc	9	8	13	11	3	3	1	3	0	0	1	3	3	3	2	2	3	2	2	2	3	2	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr4:6082004C>T	uc003giu.3	-	7	1413	c.1137G>A	c.(1135-1137)CGG>CGA	p.R379R	JAKMIP1_uc010idb.1_Silent_p.R379R|JAKMIP1_uc010idc.1_Silent_p.R214R|JAKMIP1_uc010idd.1_Silent_p.R379R|JAKMIP1_uc011bwc.1_Silent_p.R214R|JAKMIP1_uc003giv.3_Silent_p.R379R|JAKMIP1_uc010ide.2_Silent_p.R379R	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	379	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						AGGAGGTATGCCGCTTCAGAG	0.572													3	42					0	0	0	0	T	6082004	T	T	6082004	2	4	174	1	0	0	0	0	0	0	0	1	7979	726	26	4		4	JAKMIP1	4	6082004	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08		6082004	185072272	29	32613											
TERT	7015	broad.mit.edu	37	chr5	1268652	1268652	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccgtcccgccgaatcccCgcaaacagcttgttctccat	8	8	6	19	4	1	0	0	0	1	0	4	1	3	0	6	0	2	3	6	0	2	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr5:1268652C>T	uc003jcb.1	-	9	2623	c.2565G>A	c.(2563-2565)GCG>GCA	p.A855A	TERT_uc003jbz.1_Silent_p.A51A|TERT_uc003jca.1_Silent_p.A843A|TERT_uc003jcc.1_Silent_p.A855A|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	855	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCCGAATCCCCGCAAACAGCT	0.602									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				5	43					0	0	0	0	T	1268652	T	T	1268652	2	4	174	1	0	0	0	0	0	0	0	1	15830	639	23	1		1	TERT	5	1268652	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08		1268652	179646608	30	32614											
NDUFS6	4726	broad.mit.edu	37	chr5	1801427	1801428	+	5'Flank	INS	-	G	G																															ccccgacccgcgctccccgcINSccccagggcgaaataaatac																								rs150444980	by1000genomes	TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr5:1801427_1801428insG	uc003jcy.2	+						MRPL36_uc003jcx.3_5'Flank	NM_004553	NP_004544	O75380	NDUS6_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 6,						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)	1					NADH(DB00157)	GCGCTCCCCGCCCCCAGGGCGA	0.644													---	---	---								G	1801428	G	G	1801427	6	5	174	0	1	1	1	0	0	0	0	0	10350	754	26	0		0	NDUFS6	5	1801427	5'Flank	INS	-	TCGA-CV-5439-01A-01D-1683-08	532775	1801427	179113833	31	32615											
CDH9	1007	broad.mit.edu	37	chr5	26885961	26885961	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatctttccgagtcatgatTcctgctgtattatctggggg	6	15	10	10	1	3	1	1	1	2	0	5	2	5	1	3	2	1	2	3	2	2	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr5:26885961T>C	uc003jgs.1	-	11	1813	c.1644A>G	c.(1642-1644)GGA>GGG	p.G548G	CDH9_uc011cnv.1_Silent_p.G141G	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	548	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GAGTCATGATTCCTGCTGTAT	0.328													3	82					0	0	0	0	C	26885961	C	C	26885961	2	2	174	1	0	0	0	0	0	0	0	1	3132	1770	62	5		5	CDH9	5	26885961	Silent	SNP	T	TCGA-CV-5439-01A-01D-1683-08	25084534	26885961	154029299	32	32616											
ADAMTS12	81792	broad.mit.edu	37	chr5	33637800	33637800	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgacaggggtggacgttgcaCaagcgatagcgttttctttc	8	11	13	9	4	1	0	0	0	1	0	2	3	1	1	0	3	3	3	0	3	2	5			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr5:33637800C>A	uc003jia.1	-	12	1933	c.1770G>T	c.(1768-1770)TTG>TTT	p.L590F	ADAMTS12_uc010iuq.1_Missense_Mutation_p.L590F	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	590	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGACGTTGCACAAGCGATAGC	0.468										HNSCC(64;0.19)			20	48					4.35082e-09	5.04442e-09	1	0	A	33637800	A	A	33637800	3	1	174	1	0	0	0	0	1	0	0	0	257	477	17	4	3066	4	ADAMTS12	5	33637800	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	6751839	33637800	147277460	33	32617											
HSPB3	8988	broad.mit.edu	37	chr5	53751689	53751689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaagagtttgaagctcgaGgtctagaagactgcaggctg	12	8	15	6	1	1	4	0	1	1	3	2	6	1	5	0	3	2	4	0	3	4	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr5:53751689G>A	uc003jph.1	+	1	245	c.70G>A	c.(70-72)GGT>AGT	p.G24S		NM_006308	NP_006299	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3	24					cell death|response to heat|response to unfolded protein	cytoplasm|nucleus					0		Lung NSC(810;0.00104)				TGAAGCTCGAGGTCTAGAAGA	0.507													8	91					0	0	0	0	A	53751689	A	A	53751689	3	1	174	1	0	0	0	0	1	0	0	0	7460	1000	35	4	72	4	HSPB3	5	53751689	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	20113889	53751689	127163571	34	32618											
PDE8B	8622	broad.mit.edu	37	chr5	76624877	76624877	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatcctcgcagtggtttcGcgagtgtaagtgcacctccc	6	11	12	12	3	0	1	0	1	0	0	4	2	2	1	3	1	1	4	3	1	1	2	rs142671242		TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr5:76624877G>T	uc003kfa.2	+	4	690	c.645G>T	c.(643-645)TCG>TCT	p.S215S	PDE8B_uc003kfb.2_Silent_p.S195S|PDE8B_uc003kfc.2_Silent_p.S215S|PDE8B_uc003kfd.2_Silent_p.S215S|PDE8B_uc003kfe.2_Silent_p.S215S	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	215					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		CAGTGGTTTCGCGAGTGTAAG	0.488													14	12					9.05144e-12	1.10552e-11	1	0	T	76624877	T	T	76624877	2	4	174	1	0	0	0	0	0	0	0	1	11708	1074	38	3		3	PDE8B	5	76624877	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	22873188	76624877	104290383	35	32619											
GDF9	2661	broad.mit.edu	37	chr5	132197721	132197721	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgatgggaagatctcccatCctcagcagcctcttctccca	8	10	8	15	0	4	2	1	1	3	1	7	3	5	3	4	1	2	1	4	1	1	1			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr5:132197721C>T	uc003kxz.1	-	2	1177	c.925G>A	c.(925-927)GAT>AAT	p.D309N	GDF9_uc011cxj.1_Missense_Mutation_p.D221N	NM_005260	NP_005251	O60383	GDF9_HUMAN	growth differentiation factor 9 precursor	309					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			skin(1)	1		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GATCTCCCATCCTCAGCAGCC	0.522													14	35					0	0	0	0	T	132197721	T	T	132197721	3	4	174	1	0	0	0	0	1	0	0	0	6356	855	30	2	443	2	GDF9	5	132197721	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	55572844	132197721	48717539	36	32620											
SEC24A	10802	broad.mit.edu	37	chr5	134033663	134033663	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcagcacaacccagtccaaGtacagaaattacagaaggaa	19	5	7	10	0	1	2	1	0	0	2	2	3	2	3	2	1	4	2	2	1	7	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr5:134033663G>A	uc003kzs.2	+	15	2470	c.2182G>A	c.(2182-2184)GTA>ATA	p.V728I	SEC24A_uc011cxu.1_Missense_Mutation_p.V492I	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	728					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCCAGTCCAAGTACAGAAATT	0.413													4	136					0	0	0	0	A	134033663	A	A	134033663	3	1	174	1	0	0	0	0	1	0	0	0	14059	1029	36	4	2240	4	SEC24A	5	134033663	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	1835942	134033663	46881597	37	32621											
RANBP9	10048	broad.mit.edu	37	chr6	13642754	13642754	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aattcttctagaacggtctgGtctgtagatctggcaaaggc	10	12	11	8	1	5	2	0	0	5	2	5	2	5	2	0	4	1	2	0	4	5	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr6:13642754G>A	uc003nbb.2	-	7	1241	c.1182C>T	c.(1180-1182)GAC>GAT	p.D394D	RANBP9_uc003nba.2_Silent_p.D53D	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	394	LisH.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			GAACGGTCTGGTCTGTAGATC	0.373													15	38					0	0	0	0	A	13642754	A	A	13642754	2	1	174	1	0	0	0	0	0	0	0	1	13097	1252	44	4		4	RANBP9	6	13642754	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08		13642754	157472313	38	32622											
NUP153	9972	broad.mit.edu	37	chr6	17649453	17649453	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaggaagttgtgatctcagGggaactaaaattaaaggtag	16	9	13	3	0	1	2	1	1	1	1	2	4	1	4	0	4	1	2	0	4	7	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr6:17649453G>A	uc003ncd.1	-	12	1674	c.1474C>T	c.(1474-1476)CCT>TCT	p.P492S	NUP153_uc011dje.1_Missense_Mutation_p.P523S|NUP153_uc010jpl.1_Missense_Mutation_p.P492S	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	492					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GTGATCTCAGGGGAACTAAAA	0.373													21	53					0	0	0	0	A	17649453	A	A	17649453	3	1	174	1	0	0	0	0	1	0	0	0	10809	1232	43	4	2997	4	NUP153	6	17649453	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	4006699	17649453	153465614	39	32623											
ZBTB9	221504	broad.mit.edu	37	chr6	33423586	33423586	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cactctctcagactcctcagCcccagagagtatcaggggtt	9	9	9	14	0	4	2	3	0	1	2	6	3	5	2	3	2	1	2	3	2	1	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr6:33423586C>T	uc003oeq.2	+	2	977	c.709C>T	c.(709-711)CCC>TCC	p.P237S		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	237	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GACTCCTCAGCCCCAGAGAGT	0.453													22	29					0	0	0	0	T	33423586	T	T	33423586	3	4	174	1	0	0	0	0	1	0	0	0	17625	739	26	4	711	4	ZBTB9	6	33423586	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	15774133	33423586	137691481	40	32624											
BAI3	577	broad.mit.edu	37	chr6	70071099	70071099	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaagtgactatattgtgatgCccagaagttctgtaaataac	15	12	8	6	0	1	3	0	2	1	1	1	3	1	3	1	0	2	2	1	0	7	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr6:70071099C>T	uc003pev.3	+	29	4382	c.3934C>T	c.(3934-3936)CCC>TCC	p.P1312S	BAI3_uc010kak.2_Missense_Mutation_p.P1312S|BAI3_uc011dxx.1_Missense_Mutation_p.P518S	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1312	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TATTGTGATGCCCAGAAGTTC	0.398													10	36					0	0	0	0	T	70071099	T	T	70071099	3	4	174	1	0	0	0	0	1	0	0	0	1302	739	26	4	4040	4	BAI3	6	70071099	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	36647513	70071099	101043968	41	32625											
RIMS1	22999	broad.mit.edu	37	chr6	72960961	72960961	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttttagatgatgaaccgcAttggtataaacttcagacac	13	12	8	8	1	1	4	1	2	0	2	1	4	1	4	1	1	2	3	1	1	5	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr6:72960961A>T	uc003pga.2	+	15	2665	c.2588A>T	c.(2587-2589)CAT>CTT	p.H863L	RIMS1_uc011dyb.1_Missense_Mutation_p.H489L|RIMS1_uc003pgc.2_Missense_Mutation_p.H489L|RIMS1_uc010kaq.2_Missense_Mutation_p.H337L|RIMS1_uc011dyc.1_Missense_Mutation_p.H337L|RIMS1_uc010kar.2_Missense_Mutation_p.H256L|RIMS1_uc011dyd.1_Missense_Mutation_p.H322L|RIMS1_uc003pgf.2_Missense_Mutation_p.H80L|RIMS1_uc003pgg.2_Missense_Mutation_p.H80L|RIMS1_uc003pgi.2_Missense_Mutation_p.H80L|RIMS1_uc003pgh.2_Missense_Mutation_p.H80L|RIMS1_uc003pgd.2_Missense_Mutation_p.H80L|RIMS1_uc003pge.2_Missense_Mutation_p.H80L|RIMS1_uc011dye.1_5'Flank|RIMS1_uc003pgb.3_Missense_Mutation_p.H489L|RIMS1_uc010kas.1_Missense_Mutation_p.H322L	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	863					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GATGAACCGCATTGGTATAAA	0.393													4	7					0	0	0	0	T	72960961	T	T	72960961	3	4	174	1	0	0	0	0	1	0	0	0	13432	217	8	5	2809	5	RIMS1	6	72960961	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	2889862	72960961	98154106	42	32626											
SYNE1	23345	broad.mit.edu	37	chr6	152554995	152554995	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caatgcgcgacagctcagagCgcagcgtggctgtgtccacc	8	6	13	14	4	1	1	1	0	0	1	2	2	2	1	2	1	4	3	2	1	1	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr6:152554995C>A	uc010kiw.2	-	112	21235	c.20633G>T	c.(20632-20634)CGC>CTC	p.R6878L	SYNE1_uc010kiv.2_Missense_Mutation_p.R1402L|SYNE1_uc003qos.3_Missense_Mutation_p.R1402L|SYNE1_uc003qot.3_Missense_Mutation_p.R6807L|SYNE1_uc003qou.3_Missense_Mutation_p.R6878L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6878	Spectrin 21.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGCTCAGAGCGCAGCGTGGC	0.498										HNSCC(10;0.0054)			17	34					9.16793e-09	1.04033e-08	1	0	A	152554995	A	A	152554995	3	1	174	1	0	0	0	0	1	0	0	0	15511	768	27	3	5973	3	SYNE1	6	152554995	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	79594034	152554995	18560072	43	32627											
LPA	4018	broad.mit.edu	37	chr6	160969605	160969605	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcatcgcgtcaggttgcagTactcccacctgatgctgggg	7	9	13	12	2	1	1	1	1	0	0	3	1	2	1	2	3	4	5	2	3	1	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr6:160969605T>A	uc003qtl.2	-	32	5180	c.5060A>T	c.(5059-5061)TAC>TTC	p.Y1687F		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4195	Kringle 37.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CAGGTTGCAGTACTCCCACCT	0.537													20	48					0	0	0	0	A	160969605	A	A	160969605	3	1	174	1	0	0	0	0	1	0	0	0	8953	1638	57	5	1098	5	LPA	6	160969605	Missense_Mutation	SNP	T	TCGA-CV-5439-01A-01D-1683-08	8414610	160969605	10145462	44	32628											
CYP2W1	54905	broad.mit.edu	37	chr7	1027134	1027134	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccccgctgcaccgcggcCgacacacagctgggcggctt	5	5	14	17	5	0	0	0	0	0	0	0	1	0	0	4	3	3	4	4	3	0	1			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr7:1027134C>G	uc003sjq.1	+	7	1123	c.1110C>G	c.(1108-1110)GCC>GCG	p.A370A	CYP2W1_uc003sjr.1_Silent_p.A370A	NM_017781	NP_060251	Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W,	370					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GCACCGCGGCCGACACACAGC	0.711													3	1					0	0	0	0	G	1027134	G	G	1027134	2	3	174	1	0	0	0	0	0	0	0	1	4193	639	23	3		3	CYP2W1	7	1027134	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08		1027134	158111529	45	32629											
AMPH	273	broad.mit.edu	37	chr7	38433623	38433623	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgaggcactgttgcttcGagctcctctgcttcaggttg	5	13	11	12	1	2	1	1	1	1	0	4	2	3	1	2	2	3	6	2	2	0	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr7:38433623G>T	uc003tgu.2	-	18	1659	c.1590C>A	c.(1588-1590)CTC>CTA	p.L530L	AMPH_uc003tgv.2_Silent_p.L488L|AMPH_uc003tgt.2_Silent_p.L415L|AMPH_uc003tgw.1_Silent_p.L553L|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	530					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CTGTTGCTTCGAGCTCCTCTG	0.562													40	61					1.59361e-14	1.96136e-14	1	0	T	38433623	T	T	38433623	2	4	174	1	0	0	0	0	0	0	0	1	588	1045	37	3		3	AMPH	7	38433623	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	37406489	38433623	120705040	46	32630											
ZNF804B	219578	broad.mit.edu	37	chr7	88963462	88963462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcctggatgagttttcatCactggagccaagtgaacaaa	13	10	10	8	0	2	2	2	2	0	0	2	4	2	4	2	2	3	1	2	2	3	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr7:88963462C>T	uc011khi.1	+	4	1704	c.1166C>T	c.(1165-1167)TCA>TTA	p.S389L		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	389						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GAGTTTTCATCACTGGAGCCA	0.393										HNSCC(36;0.09)			10	44					0	0	0	0	T	88963462	T	T	88963462	3	4	174	1	0	0	0	0	1	0	0	0	18238	838	29	2	1180	2	ZNF804B	7	88963462	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	50529839	88963462	70175201	47	32631											
SERPINE1	5054	broad.mit.edu	37	chr7	100778862	100778862	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacagtttcaggctgacttCacgagtctttcaggtaagaa	12	11	10	8	1	4	3	3	1	1	2	4	4	4	3	0	2	0	3	0	2	2	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr7:100778862C>T	uc003uxt.2	+	6	1135	c.987C>T	c.(985-987)TTC>TTT	p.F329F	SERPINE1_uc011kkj.1_Silent_p.F314F|SERPINE1_uc003uxu.1_3'UTR	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	329					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	AGGCTGACTTCACGAGTCTTT	0.527													33	68					0	0	0	0	T	100778862	T	T	100778862	2	4	174	1	0	0	0	0	0	0	0	1	14176	825	29	2		2	SERPINE1	7	100778862	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08	11815400	100778862	58359801	48	32632											
CHD7	55636	broad.mit.edu	37	chr8	61655163	61655163	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acagcctcagggaacttatgCctctccacctcccatgtcac	9	9	6	17	0	3	0	2	0	1	0	5	1	4	1	5	1	3	0	5	1	2	1			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr8:61655163C>T	uc003xue.2	+	2	1649	c.1172C>T	c.(1171-1173)GCC>GTC	p.A391V		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	391	Pro-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GGAACTTATGCCTCTCCACCT	0.522													19	49					0	0	0	0	T	61655163	T	T	61655163	3	4	174	1	0	0	0	0	1	0	0	0	3345	739	26	4	1174	4	CHD7	8	61655163	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08		61655163	84708859	49	32633											
XKR9	389668	broad.mit.edu	37	chr8	71619348	71619348	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacaacttattcttcaactCtacattcttctggagcatgg	10	14	5	12	0	5	0	1	0	4	0	5	1	5	1	1	2	4	1	1	2	4	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr8:71619348C>G	uc003xyq.2	+	4	987	c.453C>G	c.(451-453)CTC>CTG	p.L151L	XKR9_uc010lze.2_Silent_p.L151L|XKR9_uc010lzd.2_Silent_p.L19L	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	151						integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			TTCTTCAACTCTACATTCTTC	0.393													3	70					0	0	0	0	G	71619348	G	G	71619348	2	3	174	1	0	0	0	0	0	0	0	1	17506	900	32	2		2	XKR9	8	71619348	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08	9964185	71619348	74744674	50	32634											
TERF1	7013	broad.mit.edu	37	chr8	73942569	73942569	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaattttttcttcttttaaAgtgttagtgacaaacagtct	12	18	5	6	0	3	1	0	1	3	0	3	1	3	1	0	0	1	1	0	0	5	7			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr8:73942569A>G	uc003xzd.2	+	7	913	c.888_splice	c.e7-2	p.S296_splice	TERF1_uc003xze.2_Intron	NM_017489	NP_059523	P54274	TERF1_HUMAN	telomeric repeat binding factor 1 isoform 1						age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			ovary(1)|lung(1)|skin(1)	3	Breast(64;0.218)		Epithelial(68;0.0984)			CTTCTTTTAAAGTGTTAGTGA	0.299													4	18					0	0	0	0	G	73942569	G	G	73942569	5	3	174	1	0	0	0	0	0	0	1	0	15827	86	3	5	912	5	TERF1	8	73942569	Splice_Site	SNP	A	TCGA-CV-5439-01A-01D-1683-08	2323221	73942569	72421453	51	32635											
NCALD	83988	broad.mit.edu	37	chr8	102731518	102731518	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgccttgctgatatagcCatttccgtccaggtcgtaca	7	13	8	13	2	1	1	0	1	1	0	4	1	3	1	4	1	4	2	4	1	3	5			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr8:102731518C>A	uc003yke.2	-	2	709	c.340G>T	c.(340-342)GGC>TGC	p.G114C	NCALD_uc003ykf.2_Missense_Mutation_p.G114C|NCALD_uc003ykg.2_Missense_Mutation_p.G114C|NCALD_uc003ykh.2_Missense_Mutation_p.G114C|NCALD_uc003yki.2_Missense_Mutation_p.G114C|NCALD_uc003ykj.2_Missense_Mutation_p.G114C|NCALD_uc003ykk.2_Missense_Mutation_p.G114C|NCALD_uc003ykl.2_Missense_Mutation_p.G114C	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	114	EF-hand 3.|2 (Potential).				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			CTGATATAGCCATTTCCGTCC	0.468													41	80					9.62906e-15	1.20363e-14	1	0	A	102731518	A	A	102731518	3	1	174	1	0	0	0	0	1	0	0	0	10255	594	21	4	253	4	NCALD	8	102731518	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	28788949	102731518	43632504	52	32636											
NOV	4856	broad.mit.edu	37	chr8	120435311	120435311	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctgtcacaccaactgtcCtaagaacaatgaggccttcc	12	8	6	15	0	1	2	1	1	0	1	3	2	3	2	5	1	2	0	5	1	4	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr8:120435311C>A	uc003yoq.2	+	5	1234	c.1013C>A	c.(1012-1014)CCT>CAT	p.P338H		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	338	CTCK.				regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACCAACTGTCCTAAGAACAAT	0.507													52	117					2.48254e-18	3.20328e-18	1	0	A	120435311	A	A	120435311	3	1	174	1	0	0	0	0	1	0	0	0	10607	681	24	4	1031	4	NOV	8	120435311	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	17703793	120435311	25928711	53	32637											
APBA1	320	broad.mit.edu	37	chr9	72071296	72071296	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccatcagcacaacgatgttcCcaatgtccgcaatgtaggaa	13	8	8	12	2	1	0	1	0	0	0	3	2	3	1	3	1	2	4	3	1	5	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr9:72071296C>T	uc004ahh.2	-	8	1931	c.1655G>A	c.(1654-1656)GGG>GAG	p.G552E		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	552	PID.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						AACGATGTTCCCAATGTCCGC	0.577													170	269					0	0	0	0	T	72071296	T	T	72071296	3	4	174	1	0	0	0	0	1	0	0	0	756	623	22	4	882	4	APBA1	9	72071296	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08		72071296	69142135	54	32638											
FLJ46321	389763	broad.mit.edu	37	chr9	84605871	84605871	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcccctttggcttcttcGgcttctgcgactgagtcatc	3	15	10	13	2	3	1	1	1	2	0	6	2	4	1	2	2	1	2	2	2	0	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr9:84605871G>A	uc004amn.2	+	4	533	c.486G>A	c.(484-486)TCG>TCA	p.S162S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	162						integral to membrane					0						TGGCTTCTTCGGCTTCTGCGA	0.562													6	83					0	0	0	0	A	84605871	A	A	84605871	2	1	174	1	0	0	0	0	0	0	0	1	5964	1103	39	1		1	FLJ46321	9	84605871	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	12534575	84605871	56607560	55	32639											
HABP4	22927	broad.mit.edu	37	chr9	99227713	99227713	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagaggtggccctgggaacAgagtttttgacgcttttgac	8	11	14	8	1	0	4	0	2	0	2	0	5	0	5	1	3	1	3	1	3	1	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr9:99227713A>G	uc010msg.2	+	3	755	c.607A>G	c.(607-609)AGA>GGA	p.R203G	HABP4_uc010msh.2_Intron	NM_014282	NP_055097	Q5JVS0	HABP4_HUMAN	hyaluronan binding protein 4	203					platelet activation|platelet degranulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|extracellular region|nucleus	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0169)|all_hematologic(171;0.214)				CCCTGGGAACAGAGTTTTTGA	0.478													63	96					0	0	0	0	G	99227713	G	G	99227713	3	3	174	1	0	0	0	0	1	0	0	0	6978	180	7	5	617	5	HABP4	9	99227713	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	14621842	99227713	41985718	56	32640											
GRIN3A	116443	broad.mit.edu	37	chr9	104335733	104335733	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactaaagatgtatttccgtCggttgtcatgactcagattg	10	14	9	8	2	2	3	2	1	0	2	4	3	3	3	1	1	0	2	1	1	3	5			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr9:104335733C>T	uc004bbp.1	-	9	3672	c.3071G>A	c.(3070-3072)CGA>CAA	p.R1024Q	GRIN3A_uc004bbo.1_Missense_Mutation_p.R99Q	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	1024	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GTATTTCCGTCGGTTGTCATG	0.483													66	99					0	0	0	0	T	104335733	T	T	104335733	3	4	174	1	0	0	0	0	1	0	0	0	6822	884	31	1	280	1	GRIN3A	9	104335733	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	5108020	104335733	36877698	57	32641											
ZFP37	7539	broad.mit.edu	37	chr9	115805240	115805240	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggtgagacttttggctaaagGctttcccacattcattacac	10	13	8	10	0	1	1	1	1	0	1	2	2	2	1	1	3	1	2	1	3	3	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr9:115805240G>T	uc004bgm.1	-	4	1686	c.1658C>A	c.(1657-1659)GCC>GAC	p.A553D	ZFP37_uc011lwz.1_Missense_Mutation_p.A568D|ZFP37_uc011lxa.1_Missense_Mutation_p.A554D	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	553	C2H2-type 10.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TTGGCTAAAGGCTTTCCCACA	0.383													22	92					1.50039e-11	1.81866e-11	1	0	T	115805240	T	T	115805240	3	4	174	1	0	0	0	0	1	0	0	0	17715	1203	42	4	238	4	ZFP37	9	115805240	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	11469507	115805240	25408191	58	32642											
MEGF9	1955	broad.mit.edu	37	chr9	123384920	123384920	+	Missense_Mutation	SNP	C	A	A																															gggcatcgcaactggcagacCgattattgcattggcagggc																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr9:123384920C>A	uc004bkj.1	-	5	1028	c.1028G>T	c.(1027-1029)CGG>CTG	p.R343L	MEGF9_uc011lyb.1_Missense_Mutation_p.R298L	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	306	Extracellular (Potential).|Laminin EGF-like 3.					integral to membrane	calcium ion binding				0						ACTGGCAGACCGATTATTGCA	0.423													12	29					3.41278e-10	4.1056e-10	1	0	A	123384920	A	A	123384920	3	1	174	1	0	0	0	0	1	0	0	0	9517	652	23	3	907	3	MEGF9	9	123384920	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	7579680	123384920	17828511	59	32643	64	2									
MEGF9	1955	broad.mit.edu	37	chr9	123384926	123384926	+	Missense_Mutation	SNP	T	G	G																															cgcaactggcagaccgattaTtgcattggcagggcaagcag																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr9:123384926T>G	uc004bkj.1	-	5	1022	c.1022A>C	c.(1021-1023)AAT>ACT	p.N341T	MEGF9_uc011lyb.1_Missense_Mutation_p.N296T	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	304	Extracellular (Potential).|Laminin EGF-like 3.					integral to membrane	calcium ion binding				0						AGACCGATTATTGCATTGGCA	0.423													12	28					0	0	0	0	G	123384926	G	G	123384926	3	3	174	1	0	0	0	0	1	0	0	0	9517	1493	52	5	913	5	MEGF9	9	123384926	Missense_Mutation	SNP	T	TCGA-CV-5439-01A-01D-1683-08	6	123384926	17828505	60	32644	64	2									
NOTCH1	4851	broad.mit.edu	37	chr9	139418287	139418287	+	Silent	SNP	C	A	A																															aggggtgtcaggcagaggggCccagagaagcccagggcaca																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr9:139418287C>A	uc004chz.2	-	3	285	c.285G>T	c.(283-285)GGG>GGT	p.G95G		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	95	Extracellular (Potential).|EGF-like 2.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGCAGAGGGGCCCAGAGAAGC	0.672			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			10	19					3.86212e-05	4.06539e-05	1	0	A	139418287	A	A	139418287	2	1	174	1	0	0	0	0	0	0	0	1	10601	726	26	4		4	NOTCH1	9	139418287	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08	16033361	139418287	1795144	61	32645	65	2									
NOTCH1	4851	broad.mit.edu	37	chr9	139418289	139418289	+	Missense_Mutation	SNP	C	A	A																															gggtgtcaggcagaggggccCagagaagcccagggcacagc																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr9:139418289C>A	uc004chz.2	-	3	283	c.283G>T	c.(283-285)GGG>TGG	p.G95W		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	95	Extracellular (Potential).|EGF-like 2.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CAGAGGGGCCCAGAGAAGCCC	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			10	20					3.86212e-05	4.06539e-05	1	0	A	139418289	A	A	139418289	3	1	174	1	0	0	0	0	1	0	0	0	10601	594	21	4	7512	4	NOTCH1	9	139418289	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	2	139418289	1795142	62	32646	65	2									
MAN1B1	11253	broad.mit.edu	37	chr9	139981560	139981560	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcgccaccactgtagtcAtgtacccaccgccgccgccg	6	6	9	20	6	1	0	1	0	0	0	2	0	1	0	8	0	1	2	8	0	2	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr9:139981560A>G	uc004cld.2	+	1	144	c.109A>G	c.(109-111)ATG>GTG	p.M37V	MAN1B1_uc004clc.2_5'UTR|MAN1B1_uc011meo.1_5'UTR|MAN1B1_uc011mep.1_Missense_Mutation_p.M37V|MAN1B1_uc010ncc.2_RNA|LOC100289341_uc004clb.3_5'Flank	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	37	Cytoplasmic (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CACTGTAGTCATGTACCCACC	0.662													7	9					0	0	0	0	G	139981560	G	G	139981560	3	3	174	1	0	0	0	0	1	0	0	0	9265	217	8	5	111	5	MAN1B1	9	139981560	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	563271	139981560	1231871	63	32647											
ARHGAP21	57584	broad.mit.edu	37	chr10	24873384	24873384	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttactgcctggggtttcaGacagtttatgaggttgggca	7	14	13	7	0	1	2	1	1	0	1	1	2	1	2	1	4	2	4	1	4	2	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr10:24873384G>A	uc001isb.2	-	26	6321	c.5834C>T	c.(5833-5835)TCT>TTT	p.S1945F	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1944					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TGGGGTTTCAGACAGTTTATG	0.448													41	99					0	0	0	0	A	24873384	A	A	24873384	3	1	174	1	0	0	0	0	1	0	0	0	871	942	33	2	46	2	ARHGAP21	10	24873384	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08		24873384	110661363	64	32648											
ARHGAP21	57584	broad.mit.edu	37	chr10	24955940	24955940	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtttccattttcttcatccTacaaatgaaaatatatatat	14	18	2	7	0	2	1	1	1	1	0	4	1	4	1	2	0	1	1	2	0	8	9			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr10:24955940T>A	uc001isb.2	-	4	731	c.244_splice	c.e4-1	p.D82_splice	ARHGAP21_uc009xkl.1_Splice_Site_p.D82_splice|ARHGAP21_uc001isc.1_Splice_Site_p.D82_splice|ARHGAP21_uc001isd.1_Splice_Site_p.D82_splice	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21						signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TTCTTCATCCTACAAATGAAA	0.289													3	13					0	0	0	0	A	24955940	A	A	24955940	5	1	174	1	0	0	0	0	0	0	1	0	871	1536	53	5	5726	5	ARHGAP21	10	24955940	Splice_Site	SNP	T	TCGA-CV-5439-01A-01D-1683-08	82556	24955940	110578807	65	32649											
RBP3	5949	broad.mit.edu	37	chr10	48387849	48387849	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggcacaattccaggaatgCggtccttggcattctcaggg	8	10	13	10	1	1	0	1	0	1	0	4	1	3	1	2	5	1	2	2	5	2	3	rs149031179		TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr10:48387849C>T	uc001jez.2	-	1	3143	c.3029G>A	c.(3028-3030)CGC>CAC	p.R1010H		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	1010	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	TCCAGGAATGCGGTCCTTGGC	0.597													4	116					0	0	0	0	T	48387849	T	T	48387849	3	4	174	1	0	0	0	0	1	0	0	0	13222	768	27	1	730	1	RBP3	10	48387849	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	23431909	48387849	87146898	66	32650											
FRMPD2	143162	broad.mit.edu	37	chr10	49393603	49393603	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagccctcttaccaaaaccAcgatgtgggtcacgtttcag	10	9	10	12	2	3	0	2	0	1	0	3	2	3	1	3	2	3	1	3	2	3	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr10:49393603A>G	uc001jgi.2	-	18	2459	c.2352T>C	c.(2350-2352)CGT>CGC	p.R784R	FRMPD2_uc001jgh.2_Silent_p.R752R|FRMPD2_uc001jgj.2_Silent_p.R762R	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	784	PDZ 1.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		TACCAAAACCACGATGTGGGT	0.507													17	30					0	0	0	0	G	49393603	G	G	49393603	2	3	174	1	0	0	0	0	0	0	0	1	6092	146	6	5		5	FRMPD2	10	49393603	Silent	SNP	A	TCGA-CV-5439-01A-01D-1683-08	1005754	49393603	86141144	67	32651											
SLC18A3	6572	broad.mit.edu	37	chr10	50819677	50819677	+	Frame_Shift_Del	DEL	G	-	-																															attgccgtggtggccggcgcGctcaccacctgtaacattcc																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr10:50819677delG	uc001jhw.2	+	1	1331	c.891delG	c.(889-891)GCGfs	p.A297fs	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	297	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						TGGCCGGCGCGCTCACCACCT	0.642													---	---	---								-	50819677	-	-	50819677	7	5	174	1	0	1	0	1	0	0	0	0	14492	1074	38	0	893	0	SLC18A3	10	50819677	Frame_Shift_Del	DEL	G	TCGA-CV-5439-01A-01D-1683-08	1426074	50819677	84715070	68	32652											
USP54	159195	broad.mit.edu	37	chr10	75335341	75335341	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctttgctgggggctatggAggttgagcttcgaggtgcaa	6	11	17	7	1	0	1	0	1	0	0	1	3	0	2	1	5	3	5	1	5	2	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr10:75335341A>T	uc001juo.2	-	1	93	c.76T>A	c.(76-78)TCC>ACC	p.S26T	USP54_uc001jup.2_Missense_Mutation_p.S26T|USP54_uc010qkl.1_Missense_Mutation_p.S26T	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	26					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					GGGGCTATGGAGGTTGAGCTT	0.458													22	37					0	0	0	0	T	75335341	T	T	75335341	3	4	174	1	0	0	0	0	1	0	0	0	17153	304	11	5	5066	5	USP54	10	75335341	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	24515664	75335341	60199406	69	32653											
STK33	65975	broad.mit.edu	37	chr11	8474394	8474394	+	Frame_Shift_Del	DEL	G	-	-																															tagataggagtcccacatgtGgcctgcagcatggcttcact																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:8474394delG	uc001mgi.1	-	7	1765	c.846delC	c.(844-846)GCCfs	p.A282fs	STK33_uc001mgj.1_Frame_Shift_Del_p.A282fs|STK33_uc001mgk.1_Frame_Shift_Del_p.A282fs|STK33_uc010rbn.1_Frame_Shift_Del_p.A241fs|STK33_uc001mgl.3_Frame_Shift_Del_p.A95fs|STK33_uc009yfp.2_Frame_Shift_Del_p.A4fs	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	282	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		TCCCACATGTGGCCTGCAGCA	0.328													---	---	---								-	8474394	-	-	8474394	7	5	174	1	0	1	0	1	0	0	0	0	15366	1335	47	0	722	0	STK33	11	8474394	Frame_Shift_Del	DEL	G	TCGA-CV-5439-01A-01D-1683-08		8474394	126532122	70	32654											
MICALCL	84953	broad.mit.edu	37	chr11	12379876	12379876	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagaaggatctaaacgaagaGcaagaagtattcaccgagct	17	6	11	7	2	2	3	1	0	1	3	2	7	2	4	1	1	3	3	1	1	7	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:12379876G>T	uc001mkg.1	+	9	2229	c.1938G>T	c.(1936-1938)GAG>GAT	p.E646D		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	646	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		TAAACGAAGAGCAAGAAGTAT	0.473													31	94					5.45727e-16	6.92987e-16	1	0	T	12379876	T	T	12379876	3	4	174	1	0	0	0	0	1	0	0	0	9625	962	34	4	1968	4	MICALCL	11	12379876	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	3905482	12379876	122626640	71	32655											
LRRC4C	57689	broad.mit.edu	37	chr11	40136107	40136107	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggtggctttccatgggtGtgtctcccgtaatctcatca	6	13	11	11	1	3	0	2	0	2	0	6	0	4	0	2	3	0	3	2	3	1	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:40136107G>T	uc001mxa.1	-	2	3700	c.1736C>A	c.(1735-1737)ACA>AAA	p.T579K	LRRC4C_uc001mxc.1_Missense_Mutation_p.T575K|LRRC4C_uc001mxd.1_Missense_Mutation_p.T575K|LRRC4C_uc001mxb.1_Missense_Mutation_p.T575K	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	579					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TTCCATGGGTGTGTCTCCCGT	0.448													31	73					1.55811e-20	2.02681e-20	1	0	T	40136107	T	T	40136107	3	4	174	1	0	0	0	0	1	0	0	0	9058	1377	48	4	190	4	LRRC4C	11	40136107	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	27756231	40136107	94870409	72	32656											
OR8J1	219477	broad.mit.edu	37	chr11	56128169	56128169	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgctggtctccctcacataCctctatggcttttctacagc	6	14	6	15	0	4	0	1	0	3	0	5	0	4	0	2	2	4	2	2	2	3	5	rs141638344		TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:56128169C>T	uc010rjh.1	+	1	447	c.447C>T	c.(445-447)TAC>TAT	p.Y149Y		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CCCTCACATACCTCTATGGCT	0.433													28	45					0	0	0	0	T	56128169	T	T	56128169	2	4	174	1	0	0	0	0	0	0	0	1	11295	518	18	4		4	OR8J1	11	56128169	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08	15992062	56128169	78878347	73	32657											
PC	5091	broad.mit.edu	37	chr11	66617739	66617739	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctccacataggccttcttGacctccttgaacttggagcc	7	11	8	15	0	1	2	0	2	1	0	3	3	3	3	6	2	2	0	6	2	2	5			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:66617739G>T	uc001ojn.1	-	17	2719	c.2670C>A	c.(2668-2670)GTC>GTA	p.V890V	PC_uc001ojo.1_Silent_p.V890V|PC_uc001ojp.1_Silent_p.V890V|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	890					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	AGGCCTTCTTGACCTCCTTGA	0.597													8	36					2.17888e-05	2.32414e-05	1	0	T	66617739	T	T	66617739	2	4	174	1	0	0	0	0	0	0	0	1	11551	1277	45	2		2	PC	11	66617739	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	10489570	66617739	68388777	74	32658											
FOLH1B	219595	broad.mit.edu	37	chr11	89421766	89421766	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	taaaaggataagcaaattggGatctggaaatgattttgagg	16	11	12	2	0	1	2	0	2	1	0	1	5	1	5	0	4	1	1	0	4	5	5			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:89421766G>C	uc001pda.2	+	10	1149	c.623G>C	c.(622-624)GGA>GCA	p.G208A		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	208					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						AGCAAATTGGGATCTGGAAAT	0.333													24	52					0	0	0	0	C	89421766	C	C	89421766	3	2	174	1	0	0	0	0	1	0	0	0	6012	1174	41	2	653	2	FOLH1B	11	89421766	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	22804027	89421766	45584750	75	32659											
KBTBD3	143879	broad.mit.edu	37	chr11	105923992	105923992	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagcattgtatttaaaaaagCaatcaagtgatgggttaaaa	18	12	8	3	0	1	1	1	1	0	0	1	1	1	1	0	1	2	4	0	1	9	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:105923992C>A	uc001pja.2	-	4	2064	c.1424G>T	c.(1423-1425)TGC>TTC	p.C475F	KBTBD3_uc001pjb.2_Missense_Mutation_p.C475F|KBTBD3_uc009yxm.2_Missense_Mutation_p.C396F	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	471	Kelch 4.									ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TTTAAAAAAGCAATCAAGTGA	0.358													12	28					5.50884e-06	5.9555e-06	1	0	A	105923992	A	A	105923992	3	1	174	1	0	0	0	0	1	0	0	0	8033	710	25	4	418	4	KBTBD3	11	105923992	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	16502226	105923992	29082524	76	32660											
USP28	57646	broad.mit.edu	37	chr11	113711431	113711431	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttctccccagacttcacaGcgttttctctttgagcgttt	5	18	6	12	2	3	2	1	1	2	1	5	2	3	2	2	0	2	2	2	0	0	7			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:113711431G>A	uc001poh.2	-	5	456	c.423C>T	c.(421-423)CGC>CGT	p.R141R	USP28_uc010rwy.1_Silent_p.R16R|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Silent_p.R141R|USP28_uc010rwz.1_Silent_p.R141R	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	141					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		AGACTTCACAGCGTTTTCTCT	0.428													17	36					0	0	0	0	A	113711431	A	A	113711431	2	1	174	1	0	0	0	0	0	0	0	1	17126	958	34	4		4	USP28	11	113711431	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	7787439	113711431	21295085	77	32661											
CEP164	22897	broad.mit.edu	37	chr11	117280412	117280412	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagatcagcagccagctgaGcagtgtcctcagcatcctgg	9	7	12	13	0	2	2	2	1	0	1	4	2	4	2	3	1	5	5	3	1	0	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:117280412G>T	uc001prc.2	+	30	3974	c.3827G>T	c.(3826-3828)AGC>ATC	p.S1276I	CEP164_uc001prb.2_Missense_Mutation_p.S1271I|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_Missense_Mutation_p.S701I	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1276					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		AGCCAGCTGAGCAGTGTCCTC	0.642													52	100					1.54043e-34	2.07117e-34	1	0	T	117280412	T	T	117280412	3	4	174	1	0	0	0	0	1	0	0	0	3264	971	34	4	3937	4	CEP164	11	117280412	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	3568981	117280412	17726104	78	32662											
SIAE	54414	broad.mit.edu	37	chr11	124519604	124519604	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctggaggcgatcagcccGatgggatactgcagagtgtc	9	7	15	10	2	1	1	1	0	0	1	2	5	1	3	1	3	4	2	1	3	1	1			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:124519604G>T	uc001qan.2	-	5	746	c.633C>A	c.(631-633)ATC>ATA	p.I211I		NM_170601	NP_733746	Q9HAT2	SIAE_HUMAN	sialate O-acetylesterase precursor	211						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		CGATCAGCCCGATGGGATACT	0.522													34	84					1.36615e-20	1.79167e-20	1	0	T	124519604	T	T	124519604	2	4	174	1	0	0	0	0	0	0	0	1	14363	1048	37	3		3	SIAE	11	124519604	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	7239192	124519604	10486912	79	32663											
FEZ1	9638	broad.mit.edu	37	chr11	125359582	125359582	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatggtggggagatgaaccaTagaaacactggggcttctcc	11	8	14	8	0	1	3	0	1	1	2	2	5	1	3	2	5	2	1	2	5	3	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:125359582T>C	uc001qbx.2	-	2	244	c.92A>G	c.(91-93)TAT>TGT	p.Y31C	FEZ1_uc010sbc.1_Missense_Mutation_p.Y31C|FEZ1_uc001qby.1_Missense_Mutation_p.Y31C	NM_005103	NP_005094	Q99689	FEZ1_HUMAN	zygin 1 isoform 1	31					axon guidance|cell adhesion|transport	microtubule|plasma membrane				central_nervous_system(3)|ovary(1)	4	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		AGATGAACCATAGAAACACTG	0.532													23	71					0	0	0	0	C	125359582	C	C	125359582	3	2	174	1	0	0	0	0	1	0	0	0	5855	1406	49	5	1126	5	FEZ1	11	125359582	Missense_Mutation	SNP	T	TCGA-CV-5439-01A-01D-1683-08	839978	125359582	9646934	80	32664											
KCNJ5	3762	broad.mit.edu	37	chr11	128781856	128781856	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctccgcaactcccacatcGtggaggcctccatccgggcc	7	6	9	19	3	0	0	0	0	0	0	5	1	4	1	7	3	1	1	7	3	1	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr11:128781856G>A	uc001qet.2	+	2	1002	c.688G>A	c.(688-690)GTG>ATG	p.V230M	KCNJ5_uc009zck.2_Missense_Mutation_p.V230M|KCNJ5_uc001qew.2_Missense_Mutation_p.V230M	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	230	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CTCCCACATCGTGGAGGCCTC	0.592													16	65					0	0	0	0	A	128781856	A	A	128781856	3	1	174	1	0	0	0	0	1	0	0	0	8093	1145	40	1	690	1	KCNJ5	11	128781856	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	3422274	128781856	6224660	81	32665											
EFCAB4B	84766	broad.mit.edu	37	chr12	3763444	3763444	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaactgctgctgagcatccTggagctcccaggaagtccgc	8	7	11	15	1	0	1	0	1	0	0	3	3	3	3	4	2	5	4	4	2	2	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:3763444T>A	uc001qmj.2	-	10	1552	c.980A>T	c.(979-981)CAG>CTG	p.Q327L	EFCAB4B_uc010sen.1_Missense_Mutation_p.Q327L|EFCAB4B_uc010seo.1_Missense_Mutation_p.Q327L|EFCAB4B_uc001qmi.1_RNA	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	327	Potential.				activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			CTGAGCATCCTGGAGCTCCCA	0.557													17	34					0	0	0	0	A	3763444	A	A	3763444	3	1	174	1	0	0	0	0	1	0	0	0	4959	1580	55	5	1451	5	EFCAB4B	12	3763444	Missense_Mutation	SNP	T	TCGA-CV-5439-01A-01D-1683-08		3763444	130088451	82	32666											
LRP6	4040	broad.mit.edu	37	chr12	12337036	12337036	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccattgtcaattccacatGgatttgtggctgtcaaatat	10	14	7	10	0	2	0	2	0	0	0	3	1	3	1	3	2	0	1	3	2	3	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:12337036G>A	uc001rah.3	-	5	996	c.854C>T	c.(853-855)CCA>CTA	p.P285L	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.P285L	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	285	Extracellular (Potential).|EGF-like 1.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				AATTCCACATGGATTTGTGGC	0.393													10	38					0	0	0	0	A	12337036	A	A	12337036	3	1	174	1	0	0	0	0	1	0	0	0	9012	1348	47	4	4063	4	LRP6	12	12337036	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	8573592	12337036	121514859	83	32667											
ARHGDIB	397	broad.mit.edu	37	chr12	15103494	15103494	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaggaccatctcccagcagCgttttcttgtacttaattag	10	13	7	11	1	2	0	0	0	2	0	3	1	2	1	2	1	3	3	2	1	3	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:15103494C>A	uc001rcq.1	-	2	257	c.153G>T	c.(151-153)ACG>ACT	p.T51T	ARHGDIB_uc001rcp.1_5'Flank	NM_001175	NP_001166	P52566	GDIR2_HUMAN	Rho GDP dissociation inhibitor (GDI) beta	51					actin cytoskeleton organization|cellular component movement|immune response|multicellular organismal development|negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytoskeleton|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity				0						CTCCCAGCAGCGTTTTCTTGT	0.483													21	85					1.10923e-09	1.30498e-09	1	0	A	15103494	A	A	15103494	2	1	174	1	0	0	0	0	0	0	0	1	891	755	27	3		3	ARHGDIB	12	15103494	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08	2766458	15103494	118748401	84	32668											
MGST1	4257	broad.mit.edu	37	chr12	16516968	16516968	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttgctgaaaagtaaattgtAcctgtaaagaaaatcataca	18	11	7	5	0	1	2	1	1	0	1	1	2	1	2	1	0	3	5	1	0	10	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:16516968A>G	uc001rdf.2	+	4	526	c.461A>G	c.(460-462)TAC>TGC	p.Y154C	MGST1_uc001rdg.2_Missense_Mutation_p.Y154C|MGST1_uc009zih.1_Intron|MGST1_uc001rdh.2_Missense_Mutation_p.Y154C|MGST1_uc001rdi.2_Missense_Mutation_p.Y154C	NM_145792	NP_665735	P10620	MGST1_HUMAN	microsomal glutathione S-transferase 1	154	Lumenal (By similarity).				protein homotrimerization|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane	glutathione transferase activity				0		Hepatocellular(102;0.121)			Glutathione(DB00143)	AGTAAATTGTACCTGTAAAGA	0.358													14	29					0	0	0	0	G	16516968	G	G	16516968	3	3	174	1	0	0	0	0	1	0	0	0	9613	391	14	5	471	5	MGST1	12	16516968	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	1413474	16516968	117334927	85	32669											
KCNH3	23416	broad.mit.edu	37	chr12	49943928	49943928	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacctgcacaaggaggtcctGcagctgccactgtttgaggc	8	8	12	13	0	0	1	0	1	0	0	1	2	1	2	3	3	4	4	3	3	1	1			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:49943928G>A	uc001ruh.1	+	10	1994	c.1734G>A	c.(1732-1734)CTG>CTA	p.L578L	KCNH3_uc010smj.1_Silent_p.L518L	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	578	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						AGGAGGTCCTGCAGCTGCCAC	0.701													13	23					0	0	0	0	A	49943928	A	A	49943928	2	1	174	1	0	0	0	0	0	0	0	1	8072	1306	46	4		4	KCNH3	12	49943928	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	33426960	49943928	83907967	86	32670											
KRT77	374454	broad.mit.edu	37	chr12	53086203	53086203	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacacagctgccagacccAcctgctctcctcgccctcca	9	6	6	20	1	1	1	0	0	1	1	4	2	2	1	6	0	4	2	6	0	1	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:53086203A>G	uc001saw.2	-	7	1456	c.1427_splice	c.e7+1	p.R476_splice	KRT77_uc009zmi.2_Splice_Site_p.R234_splice	NM_175078	NP_778253	Q7Z794	K2C1B_HUMAN	keratin 77							keratin filament	structural molecule activity			ovary(1)	1						TGCCAGACCCACCTGCTCTCC	0.592													9	30					0	0	0	0	G	53086203	G	G	53086203	5	3	174	1	0	0	0	0	0	0	1	0	8529	173	6	5	319	5	KRT77	12	53086203	Splice_Site	SNP	A	TCGA-CV-5439-01A-01D-1683-08	3142275	53086203	80765692	87	32671											
ITGA7	3679	broad.mit.edu	37	chr12	56089326	56089326	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgggcagaggttggaattcCgtgtcgctgacccgggtaca	8	9	15	9	3	0	2	0	1	0	1	2	3	1	3	2	4	1	4	2	4	2	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:56089326C>T	uc001shh.2	-	14	2215	c.1995G>A	c.(1993-1995)ACG>ACA	p.T665T	ITGA7_uc001shg.2_Silent_p.T661T|ITGA7_uc010sps.1_Silent_p.T568T|ITGA7_uc009znw.2_5'UTR|ITGA7_uc009znx.2_Silent_p.T542T	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	705	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						GTTGGAATTCCGTGTCGCTGA	0.597													14	85					0	0	0	0	T	56089326	T	T	56089326	2	4	174	1	0	0	0	0	0	0	0	1	7920	639	23	1		1	ITGA7	12	56089326	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08	3003123	56089326	77762569	88	32672											
TIMELESS	8914	broad.mit.edu	37	chr12	56827878	56827878	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaagcaatctggttccttaTggtaagtgtctccctccaag	9	13	8	11	0	2	0	0	0	2	0	5	0	4	0	3	2	1	3	3	2	5	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:56827878T>A	uc001slf.2	-	2	245	c.77A>T	c.(76-78)CAT>CTT	p.H26L	TIMELESS_uc001slg.2_Missense_Mutation_p.H26L	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	26					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						TGGTTCCTTATGGTAAGTGTC	0.438													14	36					0	0	0	0	A	56827878	A	A	56827878	3	1	174	1	0	0	0	0	1	0	0	0	15970	1464	51	5	3661	5	TIMELESS	12	56827878	Missense_Mutation	SNP	T	TCGA-CV-5439-01A-01D-1683-08	738552	56827878	77024017	89	32673											
SLC17A8	246213	broad.mit.edu	37	chr12	100774536	100774536	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagctgaatgaagaaggaagGccggtgcagacgtccaggcc	12	4	16	9	2	0	4	0	2	0	2	1	6	1	5	3	4	2	2	3	4	4	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:100774536G>T	uc010svi.1	+	2	472	c.159G>T	c.(157-159)AGG>AGT	p.R53S	SLC17A8_uc009ztx.2_Missense_Mutation_p.R53S	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	53	Cytoplasmic (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						AAGAAGGAAGGCCGGTGCAGA	0.502													17	128					2.94398e-08	3.29397e-08	1	0	T	100774536	T	T	100774536	3	4	174	1	0	0	0	0	1	0	0	0	14488	1194	42	4	165	4	SLC17A8	12	100774536	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	43946658	100774536	33077359	90	32674											
ASCL1	429	broad.mit.edu	37	chr12	103352676	103352676	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tactcgtcggacgagggctcTtacgacccgctcagccccga	7	7	11	16	6	2	0	1	0	1	0	4	4	2	1	3	2	3	2	3	2	2	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:103352676T>C	uc001tjr.3	+	1	1225	c.654T>C	c.(652-654)TCT>TCC	p.S218S		NM_004316	NP_004307	P50553	ASCL1_HUMAN	achaete-scute complex homolog 1	218					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity				0						ACGAGGGCTCTTACGACCCGC	0.627													13	36					0	0	0	0	C	103352676	C	C	103352676	2	2	174	1	0	0	0	0	0	0	0	1	1036	1596	56	5		5	ASCL1	12	103352676	Silent	SNP	T	TCGA-CV-5439-01A-01D-1683-08	2578140	103352676	30499219	91	32675											
TRPV4	59341	broad.mit.edu	37	chr12	110246113	110246113	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctcacctcgaaactcctCatcagttaggcgtttcttgt	7	14	8	12	2	4	0	3	0	1	0	6	1	5	0	2	2	1	3	2	2	2	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr12:110246113C>A	uc001tpj.1	-	2	642	c.547G>T	c.(547-549)GAG>TAG	p.E183*	TRPV4_uc001tpg.1_Nonsense_Mutation_p.E149*|TRPV4_uc001tph.1_Nonsense_Mutation_p.E183*|TRPV4_uc001tpi.1_Nonsense_Mutation_p.E183*|TRPV4_uc001tpk.1_Nonsense_Mutation_p.E183*|TRPV4_uc001tpl.1_Nonsense_Mutation_p.E183*	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	183	Cytoplasmic (Potential).		E -> K (found in a patient with spondyloepiphyseal dysplasia Maroteaux type).		actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CGAAACTCCTCATCAGTTAGG	0.612													6	24					2.0095e-06	2.18721e-06	1	0	A	110246113	A	A	110246113	4	1	174	1	0	0	0	0	0	1	0	0	16665	835	29	2	2124	2	TRPV4	12	110246113	Nonsense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	6893437	110246113	23605782	92	32676											
MRPL52	122704	broad.mit.edu	37	chr14	23299461	23299461	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctcccagactggtcatatgCgggtaagcgctgatctggca	8	9	13	11	2	2	2	1	1	1	1	3	2	3	2	1	3	2	4	1	3	2	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr14:23299461C>T	uc001wgw.3	+	3	185	c.155C>T	c.(154-156)GCG>GTG	p.A52V	MRPL52_uc001wgx.3_Missense_Mutation_p.A51V|MRPL52_uc001wgy.3_5'UTR|MRPL52_uc001wgz.3_5'UTR|MRPL52_uc001wha.3_5'UTR|MRPL52_uc001whb.3_Missense_Mutation_p.A52V	NM_178336	NP_848026	Q86TS9	RM52_HUMAN	mitochondrial ribosomal protein L52 isoform a	52					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TGGTCATATGCGGGTAAGCGC	0.602													5	98					0	0	0	0	T	23299461	T	T	23299461	3	4	174	1	0	0	0	0	1	0	0	0	9869	768	27	1	165	1	MRPL52	14	23299461	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08		23299461	84050079	93	32677											
DACT1	51339	broad.mit.edu	37	chr14	59112773	59112773	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caggggagtcccctaaggaaAgcgctcagctctcaggggcc	9	5	14	13	1	2	0	2	0	1	0	4	2	3	2	3	5	2	2	3	5	2	1			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr14:59112773A>G	uc001xdw.2	+	4	1596	c.1432A>G	c.(1432-1434)AGC>GGC	p.S478G	DACT1_uc010trv.1_Missense_Mutation_p.S197G|DACT1_uc001xdx.2_Missense_Mutation_p.S441G|DACT1_uc010trw.1_Missense_Mutation_p.S197G	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	478					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CCCTAAGGAAAGCGCTCAGCT	0.577													100	47					0	0	0	0	G	59112773	G	G	59112773	3	3	174	1	0	0	0	0	1	0	0	0	4239	72	3	5	1446	5	DACT1	14	59112773	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	35813312	59112773	48236767	94	32678											
C15orf2	23742	broad.mit.edu	37	chr15	24921169	24921169	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctttccgcggcctgttccGccggaacgcccgtcgcaggc	3	7	12	19	7	0	0	0	0	0	0	3	1	2	1	6	3	1	2	6	3	1	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr15:24921169G>T	uc001ywo.2	+	1	629	c.155G>T	c.(154-156)CGC>CTC	p.R52L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	52					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GGCCTGTTCCGCCGGAACGCC	0.756													6	21					0.00198382	0.00204781	1	0	T	24921169	T	T	24921169	3	4	174	1	0	0	0	0	1	0	0	0	1790	1087	38	3	157	3	C15orf2	15	24921169	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08		24921169	77610223	95	32679											
RYR3	6263	broad.mit.edu	37	chr15	33895352	33895352	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaacatcttcctgggagtcGcggagggctcagcccagtac	9	7	12	13	2	2	0	1	0	1	0	4	2	3	2	2	3	3	2	2	3	2	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr15:33895352G>A	uc001zhi.2	+	18	2021	c.1951G>A	c.(1951-1953)GCG>ACG	p.A651T	RYR3_uc010bar.2_Missense_Mutation_p.A651T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	651	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCTGGGAGTCGCGGAGGGCTC	0.527													19	105					0	0	0	0	A	33895352	A	A	33895352	3	1	174	1	0	0	0	0	1	0	0	0	13835	1087	38	1	2021	1	RYR3	15	33895352	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	8974183	33895352	68636040	96	32680											
UNC13C	440279	broad.mit.edu	37	chr15	54786889	54786889	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggttttataatgaatatgtgCgtgaacttcctgccttcaag	10	15	9	7	1	1	2	1	2	0	0	2	2	2	2	2	1	3	1	2	1	6	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr15:54786889C>T	uc002ack.2	+	18	5017	c.5017C>T	c.(5017-5019)CGT>TGT	p.R1673C		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1673	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGAATATGTGCGTGAACTTCC	0.338													6	104					0	0	0	0	T	54786889	T	T	54786889	3	4	174	1	0	0	0	0	1	0	0	0	17054	768	27	1	5087	1	UNC13C	15	54786889	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	20891537	54786889	47744503	97	32681											
ALPK3	57538	broad.mit.edu	37	chr15	85405961	85405961	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctttgggcgactggtaagcGaggagctccgagggggtgga	7	8	19	7	3	1	0	0	0	1	0	2	5	2	2	1	6	2	2	1	6	1	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr15:85405961G>A	uc002ble.2	+	10	4998	c.4831G>A	c.(4831-4833)GAG>AAG	p.E1611K	ALPK3_uc010upc.1_5'Flank	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1611	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ACTGGTAAGCGAGGAGCTCCG	0.597													18	20					0	0	0	0	A	85405961	A	A	85405961	3	1	174	1	0	0	0	0	1	0	0	0	546	1059	37	1	4869	1	ALPK3	15	85405961	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	30619072	85405961	17125431	98	32682											
GRIN2A	2903	broad.mit.edu	37	chr16	9857484	9857484	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttatgctccgggagggcCtgctaaggtctagctcccta	6	10	13	12	1	1	0	0	0	1	0	3	1	3	1	3	4	3	4	3	4	4	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr16:9857484C>A	uc002czo.3	-	13	4465	c.3917G>T	c.(3916-3918)AGG>ATG	p.R1306M	GRIN2A_uc010uym.1_Missense_Mutation_p.R1306M|GRIN2A_uc010uyn.1_Intron|GRIN2A_uc002czr.3_Intron	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1306	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCGGGAGGGCCTGCTAAGGTC	0.493													39	101					6.2361e-21	8.24609e-21	1	0	A	9857484	A	A	9857484	3	1	174	1	0	0	0	0	1	0	0	0	6818	681	24	4	481	4	GRIN2A	16	9857484	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08		9857484	80497269	99	32683											
KIAA0430	9665	broad.mit.edu	37	chr16	15729832	15729832	+	Frame_Shift_Del	DEL	C	-	-																															tgggaaagtcacttgcaatgCctgccaaattgttcctagct																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr16:15729832delC	uc002ddr.2	-	3	705	c.512delG	c.(511-513)GGCfs	p.G171fs	KIAA0430_uc002ddq.2_Frame_Shift_Del_p.G170fs|KIAA0430_uc010uzv.1_Frame_Shift_Del_p.G170fs|KIAA0430_uc010uzw.1_Frame_Shift_Del_p.G170fs|KIAA0430_uc010uzx.1_Frame_Shift_Del_p.G170fs	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	170						peroxisome	nucleotide binding|RNA binding				0						ACTTGCAATGCCTGCCAAATT	0.498													---	---	---								-	15729832	-	-	15729832	7	5	174	1	0	1	0	1	0	0	0	0	8216	739	26	0	4819	0	KIAA0430	16	15729832	Frame_Shift_Del	DEL	C	TCGA-CV-5439-01A-01D-1683-08	5872348	15729832	74624921	100	32684											
NLRC5	84166	broad.mit.edu	37	chr16	57111883	57111883	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatgccctgggggatcccAcagccctggggctggctcag	6	6	15	14	0	1	0	1	0	0	0	2	1	2	1	3	5	2	3	3	5	1	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr16:57111883A>T	uc002ekk.1	+	43	5257	c.5032A>T	c.(5032-5034)ACA>TCA	p.T1678S	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_Missense_Mutation_p.T220S|NLRC5_uc002ekr.1_Missense_Mutation_p.T565S	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1678	LRR 22.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				GGGGGATCCCACAGCCCTGGG	0.672													7	30					0	0	0	0	T	57111883	T	T	57111883	3	4	174	1	0	0	0	0	1	0	0	0	10524	159	6	5	5194	5	NLRC5	16	57111883	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	41382051	57111883	33242870	101	32685											
CDH3	1001	broad.mit.edu	37	chr16	68716358	68716358	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccatcaccacccaccctGagagcaaccagggcatcctg	11	6	7	17	0	1	1	1	1	0	1	2	2	2	1	6	1	3	2	6	1	2	1			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr16:68716358G>T	uc002ewf.2	+	9	2282	c.1150G>T	c.(1150-1152)GAG>TAG	p.E384*	CDH3_uc010vli.1_Nonsense_Mutation_p.E329*	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	384	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CACCCACCCTGAGAGCAACCA	0.592													19	52					3.62473e-10	4.32804e-10	1	0	T	68716358	T	T	68716358	4	4	174	1	0	0	0	0	0	1	0	0	3126	1291	45	2	1184	2	CDH3	16	68716358	Nonsense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	11604475	68716358	21638395	102	32686											
ATP2C2	9914	broad.mit.edu	37	chr16	84438840	84438840	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgaacctgtgtggaagaaatAcctggatcaggtaggaccag	13	7	13	8	1	1	1	1	0	0	1	1	5	1	4	3	4	2	1	3	4	5	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr16:84438840A>G	uc002fhx.2	+	3	406	c.317A>G	c.(316-318)TAC>TGC	p.Y106C	ATP2C2_uc010chj.2_Missense_Mutation_p.Y106C|ATP2C2_uc002fhy.2_Missense_Mutation_p.Y123C|ATP2C2_uc002fhz.2_5'Flank	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	106	Cytoplasmic (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						TGGAAGAAATACCTGGATCAG	0.527													6	28					0	0	0	0	G	84438840	G	G	84438840	3	3	174	1	0	0	0	0	1	0	0	0	1146	391	14	5	327	5	ATP2C2	16	84438840	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	15722482	84438840	5915913	103	32687											
TP53	7157	broad.mit.edu	37	chr17	7576896	7576897	+	Frame_Shift_Ins	INS	-	G	G																															cagtggtttcttctttggctINSggggagaggagctggtgttg																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr17:7576896_7576897insG	uc002gim.2	-	9	1143_1144	c.949_950insC	c.(949-951)CAGfs	p.Q317fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Ins_p.Q317fs|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Frame_Shift_Ins_p.Q185fs|TP53_uc010cng.1_Frame_Shift_Ins_p.Q185fs|TP53_uc002gii.1_Frame_Shift_Ins_p.Q185fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.Q317fs|TP53_uc010cni.1_Frame_Shift_Ins_p.Q317fs|TP53_uc002gij.2_Frame_Shift_Ins_p.Q317fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	317	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		Q -> H (in a kidney cancer with no family history; germline mutation and in a sporadic cancer; somatic mutation).|Q -> P (in a sporadic cancer; somatic mutation).|Q -> K (in sporadic cancers; somatic mutation).|Q -> L (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q317*(19)|p.0?(7)|p.Q317K(3)|p.Q317R(2)|p.S315fs*22(1)|p.?(1)|p.S314fs*25(1)|p.L308fs*15(1)|p.Q317P(1)|p.Q317fs*28(1)|p.Q317fs*45(1)|p.Q317fs*19(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTCTTTGGCTGGGGAGAGGAG	0.47		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								G	7576897	G	G	7576896	7	5	174	1	0	1	1	0	0	0	0	0	16448	1580	55	0	332	0	TP53	17	7576896	Frame_Shift_Ins	INS	-	TCGA-CV-5439-01A-01D-1683-08		7576896	73618314	104	32688											
MYH3	4621	broad.mit.edu	37	chr17	10555773	10555773	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtaacggtccttcaggttGtacagcacggctggctcatt	7	12	12	10	2	2	0	2	0	0	0	3	0	3	0	1	4	3	6	1	4	2	5			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr17:10555773G>A	uc002gmq.1	-	3	389	c.312C>T	c.(310-312)TAC>TAT	p.Y104Y		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	104	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CCTTCAGGTTGTACAGCACGG	0.557													28	23					0	0	0	0	A	10555773	A	A	10555773	2	1	174	1	0	0	0	0	0	0	0	1	10089	1372	48	4		4	MYH3	17	10555773	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	2978877	10555773	70639437	105	32689											
ITGA2B	3674	broad.mit.edu	37	chr17	42458334	42458334	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaggggctgtccaggacctGggagggacgtgacctcagcc	8	5	17	11	1	1	1	1	1	0	0	2	5	2	4	4	5	1	1	4	5	1	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr17:42458334G>T	uc002igt.1	-	13	1338	c.1306C>A	c.(1306-1308)CAG>AAG	p.Q436K	ITGA2B_uc002igu.1_5'UTR	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	436	Extracellular (Potential).|FG-GAP 7.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	TCCAGGACCTGGGAGGGACGT	0.642													30	66					3.00307e-07	3.31373e-07	1	0	T	42458334	T	T	42458334	3	4	174	1	0	0	0	0	1	0	0	0	7915	1357	47	4	1885	4	ITGA2B	17	42458334	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	31902561	42458334	38736876	106	32690											
KIF2B	84643	broad.mit.edu	37	chr17	51901024	51901024	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcagtcctggagcccccgcaAgaacatcgcatctgcgtctg	8	8	10	15	3	3	1	1	0	2	1	5	2	4	2	3	1	3	2	3	1	2	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr17:51901024A>T	uc002iua.2	+	1	786	c.630A>T	c.(628-630)CAA>CAT	p.Q210H	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	210	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						AGCCCCCGCAAGAACATCGCA	0.537													12	23					0	0	0	0	T	51901024	T	T	51901024	3	4	174	1	0	0	0	0	1	0	0	0	8337	69	3	5	632	5	KIF2B	17	51901024	Missense_Mutation	SNP	A	TCGA-CV-5439-01A-01D-1683-08	9442690	51901024	29294186	107	32691											
ABCA9	10350	broad.mit.edu	37	chr17	67031933	67031933	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagccagcatacatcaaaccCcaggaaagcctagcagagaa	18	3	8	12	0	1	1	1	0	0	1	1	3	1	2	4	1	6	2	4	1	6	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr17:67031933C>T	uc002jhu.2	-	7	953	c.810G>A	c.(808-810)TGG>TGA	p.W270*	ABCA9_uc010dez.2_Nonsense_Mutation_p.W270*	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	270	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					ACATCAAACCCCAGGAAAGCC	0.343													10	14					0	0	0	0	T	67031933	T	T	67031933	4	4	174	1	0	0	0	0	0	1	0	0	39	624	22	4	4196	4	ABCA9	17	67031933	Nonsense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	15130909	67031933	14163277	108	32692											
ST6GALNAC2	10610	broad.mit.edu	37	chr17	74583154	74583154	+	5'Flank	DEL	C	-	-																															aagctgtgacatgcggcaggCtgtgacatgccccagactcc																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr17:74583154delC	uc002jsg.3	-							NM_006456	NP_006447	Q9UJ37	SIA7B_HUMAN	sialyltransferase 7B						protein glycosylation	integral to Golgi membrane	sialyltransferase activity				0						ATGCGGCAGGCTGTGACATGC	0.567													---	---	---								-	74583154	-	-	74583154	6	5	174	0	1	1	0	1	0	0	0	0	15290	812	28	0		0	ST6GALNAC2	17	74583154	5'Flank	DEL	C	TCGA-CV-5439-01A-01D-1683-08	7551221	74583154	6612056	109	32693											
PLEKHJ1	55111	broad.mit.edu	37	chr19	2233901	2233901	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tatgccgaactgttccagggGgtcctgtggggaggacgggt	6	9	18	8	2	0	0	0	0	0	0	2	3	2	2	3	6	2	1	3	6	2	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr19:2233901G>C	uc002lvf.1	-	6	469	c.388C>G	c.(388-390)CCC>GCC	p.P130A	SF3A2_uc002lvg.2_5'Flank	NM_018049	NP_060519	Q9NW61	PKHJ1_HUMAN	pleckstrin homology domain containing, family J	130							protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTTCCAGGGGGTCCTGTGGG	0.692													8	29					0	0	0	0	C	2233901	C	C	2233901	3	2	174	1	0	0	0	0	1	0	0	0	12134	1232	43	4	65	4	PLEKHJ1	19	2233901	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08		2233901	56895082	110	32694											
ZNF561	93134	broad.mit.edu	37	chr19	9721791	9721791	+	Silent	SNP	T	A	A																															tcaagatgtacagcaagaccTggagttagagtaaagacttt																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr19:9721791T>A	uc002mlu.2	-	6	751	c.546A>T	c.(544-546)CCA>CCT	p.P182P	ZNF561_uc010dwu.2_Silent_p.P113P|ZNF561_uc010xkr.1_Silent_p.P46P	NM_152289	NP_689502	Q8N587	ZN561_HUMAN	zinc finger protein 561	182	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAGCAAGACCTGGAGTTAGAG	0.388													11	42					0	0	0	0	A	9721791	A	A	9721791	2	1	174	1	0	0	0	0	0	0	0	1	18059	1567	55	5		5	ZNF561	19	9721791	Silent	SNP	T	TCGA-CV-5439-01A-01D-1683-08	7487890	9721791	49407192	111	32695	66	2									
ZNF561	93134	broad.mit.edu	37	chr19	9721793	9721793	+	Missense_Mutation	SNP	G	A	A																															aagatgtacagcaagacctgGagttagagtaaagacttttc																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr19:9721793G>A	uc002mlu.2	-	6	749	c.544C>T	c.(544-546)CCA>TCA	p.P182S	ZNF561_uc010dwu.2_Missense_Mutation_p.P113S|ZNF561_uc010xkr.1_Missense_Mutation_p.P46S	NM_152289	NP_689502	Q8N587	ZN561_HUMAN	zinc finger protein 561	182	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCAAGACCTGGAGTTAGAGTA	0.388													11	43					0	0	0	0	A	9721793	A	A	9721793	3	1	174	1	0	0	0	0	1	0	0	0	18059	1174	41	2	920	2	ZNF561	19	9721793	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	2	9721793	49407190	112	32696	66	2									
DCAF15	90379	broad.mit.edu	37	chr19	14069909	14069909	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagcacctgccccctggcGcctgccagcccccctgagcc	5	4	9	23	1	0	1	0	1	0	0	0	1	0	1	9	1	5	1	9	1	0	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr19:14069909G>A	uc002mxt.2	+	7	843	c.837G>A	c.(835-837)GCG>GCA	p.A279A	DCAF15_uc002mxu.2_5'Flank	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	279										central_nervous_system(1)	1						GCCCCCTGGCGCCTGCCAGCC	0.657													142	40					0	0	0	0	A	14069909	A	A	14069909	2	1	174	1	0	0	0	0	0	0	0	1	4284	1074	38	1		1	DCAF15	19	14069909	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	4348116	14069909	45059074	113	32697											
CYP4F2	8529	broad.mit.edu	37	chr19	16003194	16003194	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaatggaaggcaggcgtcagCatccgacggtggcggctcca	10	5	15	11	4	1	0	1	0	0	0	3	2	3	1	2	6	1	3	2	6	2	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr19:16003194C>T	uc002nbs.1	-	5	500	c.450G>A	c.(448-450)ATG>ATA	p.M150I	CYP4F2_uc010xot.1_Missense_Mutation_p.M1I|CYP4F2_uc010xou.1_Missense_Mutation_p.M1I	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	150					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CAGGCGTCAGCATCCGACGGT	0.562													35	46					0	0	0	0	T	16003194	T	T	16003194	3	4	174	1	0	0	0	0	1	0	0	0	4205	710	25	4	1148	4	CYP4F2	19	16003194	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	1933285	16003194	43125789	114	32698											
TMEM59L	25789	broad.mit.edu	37	chr19	18726931	18726931	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacaatgggaaagtggtggtGtttcaggtgagacctctgac	10	10	15	6	0	2	2	1	2	1	1	2	5	2	3	1	4	0	1	1	4	2	1			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr19:18726931G>T	uc002njy.3	+	4	642	c.555G>T	c.(553-555)GTG>GTT	p.V185V	TMEM59L_uc010ebu.1_Silent_p.V185V	NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	185						Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						AAGTGGTGGTGTTTCAGGTGA	0.488													39	52					1.76056e-25	2.34741e-25	1	0	T	18726931	T	T	18726931	2	4	174	1	0	0	0	0	0	0	0	1	16252	1364	48	4		4	TMEM59L	19	18726931	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	2723737	18726931	40402052	115	32699											
ZNF536	9745	broad.mit.edu	37	chr19	30935385	30935385	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cctacaagtgcacgttgtgcGacttcgcggcttcgcaggag	7	9	13	12	5	0	0	0	0	0	0	2	2	0	1	1	2	3	4	1	2	2	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr19:30935385G>C	uc002nsu.1	+	2	1054	c.916G>C	c.(916-918)GAC>CAC	p.D306H	ZNF536_uc010edd.1_Missense_Mutation_p.D306H	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	306	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CACGTTGTGCGACTTCGCGGC	0.642													44	67					0	0	0	0	C	30935385	C	C	30935385	3	2	174	1	0	0	0	0	1	0	0	0	18041	1058	37	3	918	3	ZNF536	19	30935385	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	12208454	30935385	28193598	116	32700											
FFAR3	2865	broad.mit.edu	37	chr19	35849960	35849960	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtggacgtgctcctgctcaaCctgaccgcctcggacctgct	5	9	11	16	3	1	1	1	1	0	0	3	3	2	3	5	2	4	3	5	2	1	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr19:35849960C>T	uc002nzd.2	+	2	243	c.168C>T	c.(166-168)AAC>AAT	p.N56N	FFAR3_uc010xsu.1_RNA	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	56	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			TCCTGCTCAACCTGACCGCCT	0.667													9	81					0	0	0	0	T	35849960	T	T	35849960	2	4	174	1	0	0	0	0	0	0	0	1	5861	506	18	4		4	FFAR3	19	35849960	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08	4914575	35849960	23279023	117	32701											
TMEM145	284339	broad.mit.edu	37	chr19	42820842	42820842	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcttctcctccagcttcctCatcttcctgctgatgcttat	4	17	4	16	0	4	1	1	1	3	0	8	1	7	1	4	0	3	3	4	0	1	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr19:42820842C>T	uc002otk.1	+	10	808	c.756C>T	c.(754-756)CTC>CTT	p.L252L		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	252	Helical; (Potential).					integral to membrane					0		Prostate(69;0.00682)				CCAGCTTCCTCATCTTCCTGC	0.662													5	57					0	0	0	0	T	42820842	T	T	42820842	2	4	174	1	0	0	0	0	0	0	0	1	16125	813	29	2		2	TMEM145	19	42820842	Silent	SNP	C	TCGA-CV-5439-01A-01D-1683-08	6970882	42820842	16308141	118	32702											
LILRB1	10859	broad.mit.edu	37	chr19	55144499	55144499	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagagtctccctctcggtgCagccgggccccacggtggcc	5	6	13	17	3	2	1	0	0	2	1	4	1	2	1	5	4	2	1	5	4	0	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr19:55144499C>A	uc002qgj.2	+	8	1331	c.991C>A	c.(991-993)CAG>AAG	p.Q331K	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.Q331K|LILRB1_uc002qgk.2_Missense_Mutation_p.Q331K|LILRB1_uc002qgm.2_Missense_Mutation_p.Q331K|LILRB1_uc010erq.2_Missense_Mutation_p.Q331K|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	331	Ig-like C2-type 4.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CCTCTCGGTGCAGCCGGGCCC	0.612										HNSCC(37;0.09)			15	38					1.33834e-09	1.56302e-09	1	0	A	55144499	A	A	55144499	3	1	174	1	0	0	0	0	1	0	0	0	8831	711	25	4	1013	4	LILRB1	19	55144499	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08	12323657	55144499	3984484	119	32703											
PCSK2	5126	broad.mit.edu	37	chr20	17446068	17446068	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcagtggcggcgcaatgggGtcggcctggaatttaatcac	9	9	14	9	3	2	0	2	0	0	0	3	1	2	1	1	6	0	1	1	6	3	2			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr20:17446068G>A	uc002wpm.2	+	11	1620	c.1300G>A	c.(1300-1302)GTC>ATC	p.V434I	PCSK2_uc002wpl.2_Missense_Mutation_p.V415I|PCSK2_uc010zrm.1_Missense_Mutation_p.V399I|PCSK2_uc002wpn.2_Missense_Mutation_p.V88I	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	434					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCGCAATGGGGTCGGCCTGGA	0.562													16	25					0	0	0	0	A	17446068	A	A	17446068	3	1	174	1	0	0	0	0	1	0	0	0	11655	1261	44	4	1342	4	PCSK2	20	17446068	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08		17446068	45579452	120	32704											
SEC23B	10483	broad.mit.edu	37	chr20	18485751	18485751	+	5'Flank	DEL	A	-	-																															taatacattgcctcattcagAaaaaaaaaaaaaaattagga																								rs74180905		TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr20:18485751delA	uc002wqz.1	+						SEC23B_uc002wra.1_5'Flank|SEC23B_uc002wrb.1_5'Flank|SEC23B_uc010zsb.1_5'Flank|SEC23B_uc002wrc.1_5'Flank	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B						ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						CCTCATTCAGAAAAAAAAAAA	0.373													---	---	---								-	18485751	-	-	18485751	6	5	174	0	1	1	0	1	0	0	0	0	14057	261	9	0		0	SEC23B	20	18485751	5'Flank	DEL	A	TCGA-CV-5439-01A-01D-1683-08	1039683	18485751	44539769	121	32705											
ASXL1	171023	broad.mit.edu	37	chr20	31022483	31022483	+	Frame_Shift_Del	DEL	T	-	-																															ggtggcggcggggccaccgaTgagggaggtggcagaggcag																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr20:31022483delT	uc002wxs.2	+	12	2394	c.1968delT	c.(1966-1968)GATfs	p.D656fs	ASXL1_uc010geb.2_Frame_Shift_Del_p.D547fs	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	656	Gly-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.T639_G659>PPWD(1)|p.A640_S664>PCSGG(1)|p.T655fs*8(1)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GGGCCACCGATGAGGGAGGTG	0.701			F|N|Mis		MDS|CMML								---	---	---								-	31022483	-	-	31022483	7	5	174	1	0	1	0	1	0	0	0	0	1068	1461	51	0	2024	0	ASXL1	20	31022483	Frame_Shift_Del	DEL	T	TCGA-CV-5439-01A-01D-1683-08	12536732	31022483	32003037	122	32706											
CLTCL1	8218	broad.mit.edu	37	chr22	19195770	19195770	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtctctatataggactcaCggccctttttcctggccatc	7	13	7	14	1	2	0	1	0	1	0	5	1	3	1	3	3	0	0	3	3	3	5			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr22:19195770C>T	uc002zpb.2	-	22	3569	c.3494G>A	c.(3493-3495)CGT>CAT	p.R1165H	CLTCL1_uc011agv.1_Missense_Mutation_p.R1165H|CLTCL1_uc011agw.1_Missense_Mutation_p.R1165H|CLTCL1_uc011agt.1_5'Flank|CLTCL1_uc011agu.1_5'Flank|CLTCL1_uc010grm.1_Intron|CLTCL1_uc002zpe.2_Missense_Mutation_p.R125H|CLTCL1_uc002zpd.1_Intron	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1165	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					ATAGGACTCACGGCCCTTTTT	0.398			T	?	ALCL								21	45					0	0	0	0	T	19195770	T	T	19195770	3	4	174	1	0	0	0	0	1	0	0	0	3582	536	19	1	1472	1	CLTCL1	22	19195770	Missense_Mutation	SNP	C	TCGA-CV-5439-01A-01D-1683-08		19195770	32108796	123	32707											
SH3BP1	23616	broad.mit.edu	37	chr22	38061758	38061758	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcatgaccactgtgctcacGctcacaggagtctcccgcct	7	8	10	16	2	3	1	2	1	1	0	4	2	3	2	3	2	1	3	3	2	0	0			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr22:38061758G>T	uc003atj.1	+	17	2585	c.1698G>T	c.(1696-1698)ACG>ACT	p.T566T	PDXP_uc003atm.1_Silent_p.T257T			Q9Y3L3	3BP1_HUMAN	SubName: Full=cDNA FLJ44925 fis, clone BRAMY3014613, highly similar to Homo sapiens SH3-domain binding protein 1 (SH3BP1);	Error:Variant_position_missing_in_Q9Y3L3_after_alignment					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CTGTGCTCACGCTCACAGGAG	0.622													24	76					8.24728e-16	1.03903e-15	1	0	T	38061758	T	T	38061758	2	4	174	1	0	0	0	0	0	0	0	1	14309	1074	38	3		3	SH3BP1	22	38061758	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	18865988	38061758	13242808	124	32708											
PKDREJ	10343	broad.mit.edu	37	chr22	46655440	46655440	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttaaacaatgcacgtcgctGgtactcacagttcctctaag	11	11	7	12	2	2	0	1	0	1	0	4	0	3	0	1	1	3	4	1	1	5	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chr22:46655440G>A	uc003bhh.2	-	1	3780	c.3780C>T	c.(3778-3780)ACC>ACT	p.T1260T		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1260	Cytoplasmic (Potential).|PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GCACGTCGCTGGTACTCACAG	0.458													28	56					0	0	0	0	A	46655440	A	A	46655440	2	1	174	1	0	0	0	0	0	0	0	1	12025	1335	47	4		4	PKDREJ	22	46655440	Silent	SNP	G	TCGA-CV-5439-01A-01D-1683-08	8593682	46655440	4649126	125	32709											
FAM47A	158724	broad.mit.edu	37	chrX	34149650	34149650	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacgagtgatgggaggccccGggcggatatgggacactcca	9	5	17	10	3	0	1	0	1	0	0	1	6	1	4	3	5	0	0	3	5	1	1			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chrX:34149650G>T	uc004ddg.2	-	1	779	c.746C>A	c.(745-747)CCG>CAG	p.P249Q		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	249	Pro-rich.									ovary(4)|central_nervous_system(1)	5						GGGAGGCCCCGGGCGGATATG	0.632													12	11					2.27111e-07	2.52346e-07	1	0	T	34149650	T	T	34149650	3	4	174	1	0	0	0	0	1	0	0	0	5601	1116	39	3	1633	3	FAM47A	23	34149650	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08		34149650	121120910	126	32710											
ATRX	546	broad.mit.edu	37	chrX	76875969	76875969	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatgcttcattttttagaatAtggccttcatcacaaacaac	13	14	5	9	0	3	1	3	0	0	1	3	2	3	1	1	1	3	1	1	1	5	6			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chrX:76875969A>G	uc004ecp.3	-	20	5398	c.5166T>C	c.(5164-5166)CAT>CAC	p.H1722H	ATRX_uc004ecq.3_Silent_p.H1684H|ATRX_uc004eco.3_Silent_p.H1507H	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1722	Helicase ATP-binding.|DEGH box.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTTTTAGAATATGGCCTTCAT	0.294			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						15	3					0	0	0	0	G	76875969	G	G	76875969	2	3	174	1	0	0	0	0	0	0	0	1	1210	446	16	5		5	ATRX	23	76875969	Silent	SNP	A	TCGA-CV-5439-01A-01D-1683-08	42726319	76875969	78394591	127	32711											
ATP7A	538	broad.mit.edu	37	chrX	77301812	77301812	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacaggaaaccaacttacgaGagttatgaactgcctgcccg	13	8	9	11	2	0	2	0	1	0	1	0	4	0	3	3	1	7	1	3	1	6	3			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chrX:77301812G>C	uc004ecx.3	+	23	4408	c.4248G>C	c.(4246-4248)GAG>GAC	p.E1416D		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1416	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						CAACTTACGAGAGTTATGAAC	0.408													7	80					0	0	0	0	C	77301812	C	C	77301812	3	2	174	1	0	0	0	0	1	0	0	0	1192	933	33	2	4334	2	ATP7A	23	77301812	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	425843	77301812	77968748	128	32712											
CPXCR1	53336	broad.mit.edu	37	chrX	88008503	88008503	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcctaatgactgtagtacaGacatagagtctccatctgct	11	12	7	11	0	2	3	0	1	2	2	4	3	3	3	2	0	2	3	2	0	4	4			TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chrX:88008503G>C	uc004efd.3	+	3	347	c.88G>C	c.(88-90)GAC>CAC	p.D30H	CPXCR1_uc004efc.3_Missense_Mutation_p.D30H	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	30						intracellular	zinc ion binding			ovary(3)	3						CTGTAGTACAGACATAGAGTC	0.428													14	1					0	0	0	0	C	88008503	C	C	88008503	3	2	174	1	0	0	0	0	1	0	0	0	3851	942	33	2	90	2	CPXCR1	23	88008503	Missense_Mutation	SNP	G	TCGA-CV-5439-01A-01D-1683-08	10706691	88008503	67262057	129	32713											
MAGEC1	9947	broad.mit.edu	37	chrX	140994291	140994291	+	Frame_Shift_Del	DEL	T	-	-																															gctcaaagtacttttgagggTtttccccagtctcctctcca																										TCGA-CV-5439-01A-01D-1683-08	TCGA-CV-5439-11B-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	42a06486-b084-4497-8fe0-a8cff194e020	b56eef37-cf39-407c-9789-5425c2a1648d	g.chrX:140994291delT	uc004fbt.2	+	4	1387	c.1101delT	c.(1099-1101)GGTfs	p.G367fs	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	367							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTTTTGAGGGTTTTCCCCAGT	0.478										HNSCC(15;0.026)			---	---	---								-	140994291	-	-	140994291	7	5	174	1	0	1	0	1	0	0	0	0	9233	1712	60	0	1107	0	MAGEC1	23	140994291	Frame_Shift_Del	DEL	T	TCGA-CV-5439-01A-01D-1683-08	52985788	140994291	14276269	130	32714											
MMEL1	79258	broad.mit.edu	37	chr1	2523433	2523433	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggccgggcagctgctggtCcttgccaccctctgccatcc	4	8	11	18	1	1	0	0	0	1	0	3	0	3	0	6	3	4	3	6	3	0	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr1:2523433C>A	uc001ajy.2	-	22	2315	c.2101G>T	c.(2101-2103)GAC>TAC	p.D701Y	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	701	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		AGCTGCTGGTCCTTGCCACCC	0.617													31	11					4.4194e-11	4.96166e-11	1	0	A	2523433	A	A	2523433	3	1	175	1	0	0	0	0	1	0	0	0	9699	855	30	2	250	2	MMEL1	1	2523433	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08		2523433	246727188	1	32715											
PEX14	5195	broad.mit.edu	37	chr1	10690033	10690033	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggcgccagcaacgagagtGagcgggactagggctgcgcc	9	3	18	11	4	0	2	0	1	0	1	0	4	0	3	2	3	4	2	2	3	2	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr1:10690033G>C	uc001arn.2	+	9	1144	c.1123G>C	c.(1123-1125)GAG>CAG	p.E375Q	PEX14_uc009vmv.2_Missense_Mutation_p.E311Q|PEX14_uc010oam.1_Missense_Mutation_p.E311Q|PEX14_uc010oan.1_Missense_Mutation_p.E332Q|PEX14_uc009vmw.2_Missense_Mutation_p.E311Q	NM_004565	NP_004556	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	375					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(1)	1	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		CAACGAGAGTGAGCGGGACTA	0.706													5	19					0	0	0	0	C	10690033	C	C	10690033	3	2	175	1	0	0	0	0	1	0	0	0	11797	1291	45	2	1157	2	PEX14	1	10690033	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	8166600	10690033	238560588	2	32716											
KCNQ4	9132	broad.mit.edu	37	chr1	41303381	41303381	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccggggacaggaaggcccGggagaagggcgacaaggggc	10	0	21	10	3	0	1	0	0	0	1	0	5	0	3	2	8	0	0	2	8	3	0			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr1:41303381G>A	uc001cgh.1	+	13	1872	c.1790G>A	c.(1789-1791)CGG>CAG	p.R597Q	KCNQ4_uc001cgi.1_Missense_Mutation_p.R543Q	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	597	Cytoplasmic.|A-domain (Tetramerization).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			AGGAAGGCCCGGGAGAAGGGC	0.642													8	9					0	0	0	0	A	41303381	A	A	41303381	3	1	175	1	0	0	0	0	1	0	0	0	8124	1116	39	1	1840	1	KCNQ4	1	41303381	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	30613348	41303381	207947240	3	32717											
GBP6	163351	broad.mit.edu	37	chr1	89834114	89834114	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctaggttggcagttgccatgGaatctggacccaaaatgttg	10	11	12	8	0	1	0	0	0	1	0	1	2	1	2	2	4	1	4	2	4	4	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr1:89834114G>T	uc001dnf.2	+	2	278	c.4G>T	c.(4-6)GAA>TAA	p.E2*	GBP6_uc010ost.1_Intron	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	2							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		AGTTGCCATGGAATCTGGACC	0.443													15	29					3.45872e-05	3.63762e-05	1	0	T	89834114	T	T	89834114	4	4	175	1	0	0	0	0	0	1	0	0	6313	1175	41	2	6	2	GBP6	1	89834114	Nonsense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	48530733	89834114	159416507	4	32718											
DENND4B	9909	broad.mit.edu	37	chr1	153907346	153907346	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgttctctcaagggctggCggaactgagcagcccccagg	7	6	14	14	2	2	1	1	1	1	0	3	2	2	2	3	4	3	3	3	4	2	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr1:153907346C>T	uc001fdd.1	-	18	3064	c.2663G>A	c.(2662-2664)CGC>CAC	p.R888H	uc001fdc.1_RNA	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	888	Gln-rich.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAAGGGCTGGCGGAACTGAGC	0.453													20	117					0	0	0	0	T	153907346	T	T	153907346	3	4	175	1	0	0	0	0	1	0	0	0	4456	768	27	1	1871	1	DENND4B	1	153907346	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	64073232	153907346	95343275	5	32719											
ANGEL2	90806	broad.mit.edu	37	chr1	213186481	213186481	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctcatctccctcagcgttCatgacgtaactagagagatg	10	10	10	11	2	4	3	3	1	1	2	5	4	4	3	1	1	2	3	1	1	2	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr1:213186481C>G	uc001hjz.2	-	2	494	c.339G>C	c.(337-339)ATG>ATC	p.M113I	ANGEL2_uc010pto.1_Intron|ANGEL2_uc010ptp.1_Intron|ANGEL2_uc001hka.2_Intron|ANGEL2_uc010ptq.1_Intron|ANGEL2_uc001hkb.2_Missense_Mutation_p.M91I	NM_144567	NP_653168	Q5VTE6	ANGE2_HUMAN	LOC90806 protein	113											0				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		CCTCAGCGTTCATGACGTAAC	0.408													17	73					0	0	0	0	G	213186481	G	G	213186481	3	3	175	1	0	0	0	0	1	0	0	0	609	826	29	2	1327	2	ANGEL2	1	213186481	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	59279135	213186481	36064140	6	32720											
PGBD2	267002	broad.mit.edu	37	chr1	249210815	249210815	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	taacagagatgtcattgctgGgagaggtatccactcaaagg	13	9	12	7	0	2	2	2	0	0	2	3	4	3	2	1	3	2	2	1	3	3	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr1:249210815G>A	uc001ifh.2	+	3	179	c.32G>A	c.(31-33)GGG>GAG	p.G11E	PGBD2_uc001ifg.2_Intron|PGBD2_uc009xhd.2_Missense_Mutation_p.G8E	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	11										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GTCATTGCTGGGAGAGGTATC	0.463													12	17					0	0	0	0	A	249210815	A	A	249210815	3	1	175	1	0	0	0	0	1	0	0	0	11836	1232	43	4	38	4	PGBD2	1	249210815	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	36024334	249210815	39806	7	32721											
TFCP2L1	29842	broad.mit.edu	37	chr2	121997182	121997182	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccattgtagcttggggacGgggcgctgttcacctggtag	7	10	15	9	2	1	0	1	0	0	0	1	1	1	1	2	5	2	5	2	5	3	5	rs137971940		TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr2:121997182G>A	uc002tmx.2	-	8	905	c.812C>T	c.(811-813)CCG>CTG	p.P271L	TFCP2L1_uc010flr.2_Missense_Mutation_p.P271L	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	271					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					GCTTGGGGACGGGGCGCTGTT	0.612													21	24					0	0	0	0	A	121997182	A	A	121997182	3	1	175	1	0	0	0	0	1	0	0	0	15862	1116	39	1	659	1	TFCP2L1	2	121997182	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08		121997182	121202191	8	32722											
TTN	7273	broad.mit.edu	37	chr2	179484357	179484357	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagggactgacctgccagttCaagcttagctctggcttctt	8	12	10	11	0	3	1	1	1	2	0	3	2	3	2	2	2	3	4	2	2	3	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr2:179484357C>G	uc010zfg.1	-	199	39207	c.38983G>C	c.(38983-38985)GAA>CAA	p.E12995Q	TTN_uc010zfh.1_Missense_Mutation_p.E6690Q|TTN_uc010zfi.1_Missense_Mutation_p.E6623Q|TTN_uc010zfj.1_Missense_Mutation_p.E6498Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13922							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTGCCAGTTCAAGCTTAGCT	0.383													12	51					0	0	0	0	G	179484357	G	G	179484357	3	3	175	1	0	0	0	0	1	0	0	0	16803	835	29	2	61458	2	TTN	2	179484357	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	57487175	179484357	63715016	9	32723											
ZNF804A	91752	broad.mit.edu	37	chr2	185802803	185802803	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccttctgaaaccaatggtGaaactgagcatttagaaatg	14	12	8	7	0	1	4	0	3	1	1	2	4	2	4	2	1	3	1	2	1	5	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr2:185802803G>A	uc002uph.2	+	4	3274	c.2680G>A	c.(2680-2682)GAA>AAA	p.E894K		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	894						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AACCAATGGTGAAACTGAGCA	0.403													10	51					0	0	0	0	A	185802803	A	A	185802803	3	1	175	1	0	0	0	0	1	0	0	0	18237	1291	45	2	2694	2	ZNF804A	2	185802803	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	6318446	185802803	57396570	10	32724											
STAT4	6775	broad.mit.edu	37	chr2	191900890	191900890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctatctaccagctctcacCtgtaagcttctctgccagca	8	12	5	16	0	4	0	1	0	4	0	6	0	4	0	3	0	5	4	3	0	3	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr2:191900890C>T	uc002usm.1	-	17	1824	c.1570G>A	c.(1570-1572)GTC>ATC	p.V524I	STAT4_uc002usn.1_Missense_Mutation_p.V524I|STAT4_uc010zgk.1_Missense_Mutation_p.V369I|STAT4_uc002uso.2_Missense_Mutation_p.V524I	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	524					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			CAGCTCTCACCTGTAAGCTTC	0.423													10	14					0	0	0	0	T	191900890	T	T	191900890	3	4	175	1	0	0	0	0	1	0	0	0	15333	695	24	4	708	4	STAT4	2	191900890	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	6098087	191900890	51298483	11	32725											
PASK	23178	broad.mit.edu	37	chr2	242078139	242078139	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccacgcagcataggcggCgctcctgccgcatcctcttc	6	7	9	19	4	1	0	0	0	1	0	4	0	3	0	5	2	2	4	5	2	1	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr2:242078139C>T	uc002wao.1	-	5	763	c.671G>A	c.(670-672)CGC>CAC	p.R224H	PASK_uc010zol.1_Missense_Mutation_p.R38H|PASK_uc010zom.1_Missense_Mutation_p.R224H|PASK_uc010fzl.1_Missense_Mutation_p.R224H|PASK_uc010zon.1_Missense_Mutation_p.R5H|PASK_uc002waq.2_Missense_Mutation_p.R224H	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	224					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity	p.R224C(1)		ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GCATAGGCGGCGCTCCTGCCG	0.572													27	17					0	0	0	0	T	242078139	T	T	242078139	3	4	175	1	0	0	0	0	1	0	0	0	11526	768	27	1	3356	1	PASK	2	242078139	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	50177249	242078139	1121234	12	32726											
GHRL	51738	broad.mit.edu	37	chr3	10331501	10331501	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctccatcttccgggcggAgccagcctgctagagctcgg	6	7	13	15	3	1	1	0	0	1	1	4	3	3	2	5	3	4	2	5	3	1	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr3:10331501A>T	uc010hdf.2	-	3	305	c.170T>A	c.(169-171)CTC>CAC	p.L57H	GHRLOS_uc011atx.1_Intron|GHRLOS_uc011aty.1_Intron|GHRLOS_uc011atz.1_Intron|GHRLOS_uc011aua.1_Intron|GHRLOS_uc010hdl.2_Intron|GHRLOS_uc011aub.1_Intron|GHRLOS_uc010hdm.2_Intron|GHRLOS_uc011auc.1_Intron|GHRLOS_uc011aud.1_Intron|GHRLOS_uc011aue.1_Intron|GHRLOS_uc011auf.1_Intron|GHRLOS_uc011aug.1_Intron|GHRLOS_uc011auh.1_Intron|GHRLOS_uc011aui.1_Intron|GHRLOS_uc011auj.1_Intron|GHRLOS_uc010hdn.2_Intron|GHRL_uc010hda.1_RNA|GHRL_uc010hdb.1_RNA|GHRL_uc003bvj.1_Missense_Mutation_p.L57H|GHRL_uc003bvk.3_RNA|GHRL_uc010hdk.2_Missense_Mutation_p.L44H|GHRL_uc010hdc.2_Intron|GHRL_uc010hdd.2_Intron|GHRL_uc010hde.2_Missense_Mutation_p.L56H|GHRL_uc010hdi.2_Missense_Mutation_p.L57H|GHRL_uc010hdh.2_Missense_Mutation_p.L57H|GHRL_uc010hdj.2_Missense_Mutation_p.L45H|GHRLOS_uc011auk.1_Intron	NM_016362	NP_057446	Q9UBU3	GHRL_HUMAN	ghrelin/obestatin isoform 1 preproprotein	57					actin polymerization or depolymerization|activation of MAPK activity|adult feeding behavior|cartilage development|cortisol secretion|decidualization|dendrite development|elevation of cytosolic calcium ion concentration|G-protein coupled receptor protein signaling pathway|glucose metabolic process|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of angiogenesis|negative regulation of circadian sleep/wake cycle, REM sleep|negative regulation of endothelial cell proliferation|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of circadian sleep/wake cycle, non-REM sleep|positive regulation of corticotropin secretion|positive regulation of cortisol secretion|positive regulation of growth hormone secretion|positive regulation of insulin secretion|positive regulation of synaptogenesis|response to estrogen stimulus	axon|endoplasmic reticulum lumen|extracellular space|stored secretory granule	ghrelin receptor binding|growth hormone-releasing hormone activity|protein tyrosine kinase activator activity			ovary(1)	1						TTCCGGGCGGAGCCAGCCTGC	0.587													60	36					0	0	0	0	T	10331501	T	T	10331501	3	4	175	1	0	0	0	0	1	0	0	0	6411	304	11	5	195	5	GHRL	3	10331501	Missense_Mutation	SNP	A	TCGA-CV-5440-01A-01D-1512-08		10331501	187690929	13	32727											
KLHDC8B	200942	broad.mit.edu	37	chr3	49210467	49210467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagtggtgggtggtgtggatGaggtccagagcccggtagct	6	10	19	6	1	0	2	0	1	0	1	1	3	1	3	2	6	2	2	2	6	2	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr3:49210467G>A	uc003cwh.2	+	2	450	c.265G>A	c.(265-267)GAG>AAG	p.E89K	KLHDC8B_uc003cwi.1_5'Flank	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	89	Kelch 3.					cytoplasm					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGGTGTGGATGAGGTCCAGAG	0.662													13	2					0	0	0	0	A	49210467	A	A	49210467	3	1	175	1	0	0	0	0	1	0	0	0	8402	1291	45	2	267	2	KLHDC8B	3	49210467	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	38878966	49210467	148811963	14	32728											
OR5K2	402135	broad.mit.edu	37	chr3	98217323	98217323	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttagaccaaatttgcttgaaGaaggaggtaatgatatacca	16	11	9	5	0	0	4	0	2	0	2	0	5	0	5	2	2	2	2	2	2	7	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr3:98217323G>A	uc011bgx.1	+	1	799	c.799G>A	c.(799-801)GAA>AAA	p.E267K		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TTTGCTTGAAGAAGGAGGTAA	0.328													32	4					0	0	0	0	A	98217323	A	A	98217323	3	1	175	1	0	0	0	0	1	0	0	0	11221	943	33	2	801	2	OR5K2	3	98217323	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	49006856	98217323	99805107	15	32729											
PCCB	5096	broad.mit.edu	37	chr3	135974807	135974807	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattttggaatggctgctgAtaagaataaggtatttgttc	12	15	11	3	0	0	3	0	1	0	2	1	4	0	4	0	3	1	4	0	3	5	7			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr3:135974807A>T	uc003eqy.1	+	2	344	c.293A>T	c.(292-294)GAT>GTT	p.D98V	PCCB_uc003eqz.1_Missense_Mutation_p.D98V|PCCB_uc011bmc.1_Missense_Mutation_p.D98V|PCCB_uc011bmd.1_Missense_Mutation_p.D15V	NM_000532	NP_000523	P05166	PCCB_HUMAN	propionyl Coenzyme A carboxylase, beta	98	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity				0					Biotin(DB00121)|L-Valine(DB00161)	ATGGCTGCTGATAAGAATAAG	0.433													11	55					0	0	0	0	T	135974807	T	T	135974807	3	4	175	1	0	0	0	0	1	0	0	0	11559	333	12	5	299	5	PCCB	3	135974807	Missense_Mutation	SNP	A	TCGA-CV-5440-01A-01D-1512-08	37757484	135974807	62047623	16	32730											
HLTF	6596	broad.mit.edu	37	chr3	148791054	148791054	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagcatgcactggcatactAtagcttggtccagctcttcc	8	11	9	13	0	1	0	0	0	1	0	3	0	3	0	2	2	5	6	2	2	3	5			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr3:148791054A>G	uc003ewq.1	-	5	803	c.585T>C	c.(583-585)TAT>TAC	p.Y195Y	HLTF_uc003ewr.1_Silent_p.Y195Y|HLTF_uc003ews.1_Silent_p.Y195Y|HLTF_uc010hve.1_Silent_p.Y195Y	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	195					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CTGGCATACTATAGCTTGGTC	0.353													36	14					0	0	0	0	G	148791054	G	G	148791054	2	3	175	1	0	0	0	0	0	0	0	1	7254	456	16	5		5	HLTF	3	148791054	Silent	SNP	A	TCGA-CV-5440-01A-01D-1512-08	12816247	148791054	49231376	17	32731											
TP63	8626	broad.mit.edu	37	chr3	189612152	189612152	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggctccagtgagacccgggGtgagcgtgttattgatgctg	6	10	17	8	2	0	3	0	3	0	1	1	4	1	3	2	3	2	3	2	3	1	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr3:189612152G>T	uc003fry.2	+	14	1993	c.1904G>T	c.(1903-1905)GGT>GTT	p.G635V	TP63_uc003frz.2_3'UTR|TP63_uc010hzc.1_3'UTR|TP63_uc003fsc.2_Missense_Mutation_p.G541V|TP63_uc003fsd.2_3'UTR|TP63_uc010hzd.1_Missense_Mutation_p.G456V	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	635	Transactivation inhibition.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GAGACCCGGGGTGAGCGTGTT	0.577									Hay-Wells_syndrome	HNSCC(45;0.13)			15	94					1.5739e-10	1.74559e-10	1	0	T	189612152	T	T	189612152	3	4	175	1	0	0	0	0	1	0	0	0	16459	1261	44	4	2123	4	TP63	3	189612152	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	40821098	189612152	8410278	18	32732											
SGCB	6443	broad.mit.edu	37	chr4	52894901	52894901	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaataaatcataccctttCagtagatgccttttgaacat	13	13	5	10	0	2	2	2	1	0	1	2	2	2	2	3	0	3	1	3	0	6	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr4:52894901C>T	uc003gzj.2	-	4	676	c.616G>A	c.(616-618)GAA>AAA	p.E206K	SGCB_uc011bzp.1_Missense_Mutation_p.E136K	NM_000232	NP_000223	Q16585	SGCB_HUMAN	sarcoglycan, beta	206	Extracellular (Potential).|Cys-rich.				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma					0			GBM - Glioblastoma multiforme(4;7.63e-12)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CATACCCTTTCAGTAGATGCC	0.338													4	39					0	0	0	0	T	52894901	T	T	52894901	3	4	175	1	0	0	0	0	1	0	0	0	14265	835	29	2	352	2	SGCB	4	52894901	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08		52894901	138259375	19	32733											
UGT2B4	7363	broad.mit.edu	37	chr4	70351035	70351035	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcatgtgtgcaatgttatCaggttgatctgcaaacaatg	11	14	9	7	0	3	1	2	1	1	0	3	1	3	1	0	1	3	4	0	1	4	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr4:70351035C>G	uc003hek.3	-	5	1248	c.1201G>C	c.(1201-1203)GAT>CAT	p.D401H	UGT2B4_uc011cap.1_Missense_Mutation_p.D265H|UGT2B4_uc003hel.3_Intron	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	401					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						GCAATGTTATCAGGTTGATCT	0.443													30	54					0	0	0	0	G	70351035	G	G	70351035	3	3	175	1	0	0	0	0	1	0	0	0	17029	826	29	2	393	2	UGT2B4	4	70351035	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	17456134	70351035	120803241	20	32734											
SPEF2	79925	broad.mit.edu	37	chr5	35705828	35705828	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatattttgataaaaatCaatgctgaaatagataagga	21	11	7	2	0	1	3	1	2	0	1	1	5	1	4	0	1	1	1	0	1	10	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr5:35705828C>A	uc003jjo.2	+	18	2694	c.2583C>A	c.(2581-2583)ATC>ATA	p.I861I	SPEF2_uc003jjq.3_Silent_p.I856I|SPEF2_uc003jjp.1_Silent_p.I347I	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	861					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGATAAAAATCAATGCTGAAA	0.274													3	23					0.004672	0.00480324	1	0	A	35705828	A	A	35705828	2	1	175	1	0	0	0	0	0	0	0	1	15101	816	29	2		2	SPEF2	5	35705828	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08		35705828	145209432	21	32735											
MTX3	345778	broad.mit.edu	37	chr5	79284343	79284343	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctctggtcaggagaatcCtattcagtgctcccttagac	8	12	9	12	0	3	2	2	0	1	2	6	3	6	2	3	2	1	1	3	2	3	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr5:79284343C>T	uc010jag.2	-	5	473	c.446G>A	c.(445-447)AGG>AAG	p.R149K	MTX3_uc010jah.2_Missense_Mutation_p.R149K|MTX3_uc003kge.3_Missense_Mutation_p.R88K|MTX3_uc003kgf.1_5'Flank	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	149					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		CAGGAGAATCCTATTCAGTGC	0.458													10	2					0	0	0	0	T	79284343	T	T	79284343	3	4	175	1	0	0	0	0	1	0	0	0	10022	681	24	4	512	4	MTX3	5	79284343	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	43578515	79284343	101630917	22	32736											
CHSY3	337876	broad.mit.edu	37	chr5	129241116	129241116	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcggacctgggcgcgtttCatcccgggccgcgtggagtt	4	8	16	13	6	1	0	1	0	0	0	2	2	2	2	3	4	1	2	3	4	0	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr5:129241116C>T	uc003kvd.2	+	1	594	c.594C>T	c.(592-594)TTC>TTT	p.F198F		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	198	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		GGGCGCGTTTCATCCCGGGCC	0.721													7	10					0	0	0	0	T	129241116	T	T	129241116	2	4	175	1	0	0	0	0	0	0	0	1	3428	825	29	2		2	CHSY3	5	129241116	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08	49956773	129241116	51674144	23	32737											
SEC24A	10802	broad.mit.edu	37	chr5	134044567	134044567	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccactttttgtgttggctCtccttaaacaggtaagaaaa	11	14	7	9	0	1	1	0	0	1	1	3	1	2	1	2	2	1	3	2	2	5	5			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr5:134044567C>G	uc003kzs.2	+	18	3004	c.2716C>G	c.(2716-2718)CTC>GTC	p.L906V	SEC24A_uc011cxu.1_Missense_Mutation_p.L670V	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	906					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGTGTTGGCTCTCCTTAAACA	0.299													16	2					0	0	0	0	G	134044567	G	G	134044567	3	3	175	1	0	0	0	0	1	0	0	0	14059	913	32	2	2786	2	SEC24A	5	134044567	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	4803451	134044567	46870693	24	32738											
MDC1	9656	broad.mit.edu	37	chr6	30681733	30681733	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagagcaagtcagcaaagaGaatcaattcctggtccctca	14	7	9	11	0	3	2	3	0	0	2	5	3	5	2	2	1	2	3	2	1	4	1	rs137893469	by1000genomes	TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr6:30681733G>A	uc003nrg.3	-	3	804	c.364C>T	c.(364-366)CTC>TTC	p.L122F	MDC1_uc003nrf.3_5'Flank|MDC1_uc011dmp.1_Intron|MDC1_uc003nrh.1_Intron|MDC1_uc003nri.2_Missense_Mutation_p.L122F	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	122	Interaction with the MRN complex.|Interaction with CHEK2.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TCAGCAAAGAGAATCAATTCC	0.552								Other_conserved_DNA_damage_response_genes					35	14					0	0	0	0	A	30681733	A	A	30681733	3	1	175	1	0	0	0	0	1	0	0	0	9456	942	33	2	5957	2	MDC1	6	30681733	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08		30681733	140433334	25	32739											
MDC1	9656	broad.mit.edu	37	chr6	30681830	30681830	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttaaggctcccacagtctcgGaggataggtgccttgtccca	8	10	11	12	1	1	0	0	0	1	0	4	2	3	2	3	4	1	1	3	4	2	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr6:30681830G>A	uc003nrg.3	-	3	707	c.267C>T	c.(265-267)CTC>CTT	p.L89L	MDC1_uc003nrf.3_5'Flank|MDC1_uc011dmp.1_5'UTR|MDC1_uc003nrh.1_5'UTR|MDC1_uc003nri.2_Silent_p.L89L	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	89	Interaction with the MRN complex.|FHA.|Interaction with CHEK2.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CACAGTCTCGGAGGATAGGTG	0.517								Other_conserved_DNA_damage_response_genes					22	6					0	0	0	0	A	30681830	A	A	30681830	2	1	175	1	0	0	0	0	0	0	0	1	9456	1161	41	2		2	MDC1	6	30681830	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08	97	30681830	140433237	26	32740											
CCHCR1	54535	broad.mit.edu	37	chr6	31122387	31122387	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcaggccctcagcctcagcTcggccggccttctccgcccg	3	6	11	21	5	3	0	2	0	1	0	5	0	3	0	6	3	2	2	6	3	0	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr6:31122387T>A	uc003nsr.3	-	4	543	c.420A>T	c.(418-420)CGA>CGT	p.R140R	CCHCR1_uc011dne.1_Silent_p.R140R|CCHCR1_uc003nsq.3_Silent_p.R193R|CCHCR1_uc003nsp.3_Silent_p.R229R|CCHCR1_uc010jsk.1_Silent_p.R140R	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	140	Potential.				cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						CAGCCTCAGCTCGGCCGGCCT	0.662													179	60					0	0	0	0	A	31122387	A	A	31122387	2	1	175	1	0	0	0	0	0	0	0	1	2890	1538	54	5		5	CCHCR1	6	31122387	Silent	SNP	T	TCGA-CV-5440-01A-01D-1512-08	440557	31122387	139992680	27	32741											
TMEM14A	28978	broad.mit.edu	37	chr6	52550825	52550825	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcctcatgatgatcctgaGacttgtcttgttgctgctct	6	15	9	11	0	3	3	1	3	2	1	4	4	4	3	2	0	3	3	2	0	0	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr6:52550825G>C	uc003pax.2	+	5	454	c.278G>C	c.(277-279)AGA>ACA	p.R93T		NM_014051	NP_054770	Q9Y6G1	TM14A_HUMAN	transmembrane protein 14A	93	Helical; (Potential).					integral to membrane					0	Lung NSC(77;0.118)					ATGATCCTGAGACTTGTCTTG	0.408													43	15					0	0	0	0	C	52550825	C	C	52550825	3	2	175	1	0	0	0	0	1	0	0	0	16129	942	33	2	292	2	TMEM14A	6	52550825	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	21428438	52550825	118564242	28	32742											
GPRC6A	222545	broad.mit.edu	37	chr6	117121842	117121842	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcttagtgacagtcatgtGtccattgatctccttccaga	9	14	7	11	0	3	3	1	2	2	1	6	3	5	3	3	0	0	0	3	0	1	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr6:117121842G>T	uc003pxj.1	-	4	1475	c.1453C>A	c.(1453-1455)CAC>AAC	p.H485N	GPRC6A_uc003pxk.1_Missense_Mutation_p.H310N|GPRC6A_uc003pxl.1_Intron	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	485	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ACAGTCATGTGTCCATTGATC	0.383													15	45					3.27435e-08	3.58806e-08	1	0	T	117121842	T	T	117121842	3	4	175	1	0	0	0	0	1	0	0	0	6767	1377	48	4	1339	4	GPRC6A	6	117121842	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	64571017	117121842	53993225	29	32743											
NOX3	50508	broad.mit.edu	37	chr6	155743937	155743938	+	Missense_Mutation	DNP	GG	CT	CT																															cggcaacgcacacacacactGggtagtgaaatacatctgtc																										TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr6:155743937_155743938GG>CT	uc003qqm.2	-	10	1301_1302	c.1198_1199CC>AG	c.(1198-1200)CCA>AGA	p.P400R		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	400	Helical; (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CACACACACTGGGTAGTGAAAT	0.53													30	44					0	0	0	0	CT	155743938	CT	CT	155743937	3	2	175	1	0	0	0	0	1	0	0	0	10611	1348	47	4	523	4	NOX3	6	155743937	Missense_Mutation	DNP	GG	TCGA-CV-5440-01A-01D-1512-08	38622095	155743937	15371130	30	32744											
PACRG	135138	broad.mit.edu	37	chr6	163510334	163510334	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggtcatctgtgtcactctCaaggtcctccagcatctggt	7	12	9	13	0	5	0	3	0	3	0	8	0	7	0	2	3	1	1	2	3	1	0			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr6:163510334C>G	uc003qua.2	+	5	731	c.507C>G	c.(505-507)CTC>CTG	p.L169L	PACRG_uc003qub.2_Silent_p.L169L|PACRG_uc003quc.2_Silent_p.L169L	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	169											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		GTGTCACTCTCAAGGTCCTCC	0.448													12	26					0	0	0	0	G	163510334	G	G	163510334	2	3	175	1	0	0	0	0	0	0	0	1	11424	813	29	2		2	PACRG	6	163510334	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08	7766397	163510334	7604733	31	32745											
PDE1C	5137	broad.mit.edu	37	chr7	31848696	31848696	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagtgatccttcttgtctgTcttatttttaccatctttga	7	20	6	8	0	4	3	0	2	4	1	5	3	5	3	2	0	1	0	2	0	2	7			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr7:31848696T>C	uc003tcm.1	-	16	2309	c.1840A>G	c.(1840-1842)ACA>GCA	p.T614A	PDE1C_uc003tcn.1_Missense_Mutation_p.T614A|PDE1C_uc003tco.1_Missense_Mutation_p.T674A|PDE1C_uc003tcr.2_Missense_Mutation_p.T614A|PDE1C_uc003tcs.2_Missense_Mutation_p.T614A	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	614					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TTCTTGTCTGTCTTATTTTTA	0.328													9	18					0	0	0	0	C	31848696	C	C	31848696	3	2	175	1	0	0	0	0	1	0	0	0	11689	1667	58	5	72	5	PDE1C	7	31848696	Missense_Mutation	SNP	T	TCGA-CV-5440-01A-01D-1512-08		31848696	127289967	32	32746											
TNS3	64759	broad.mit.edu	37	chr7	47384376	47384388	+	Frame_Shift_Del	DEL	GCTGGGCTGCTCA	-	-																															gtcctcctttgtgctgactgGctgggctgctcagcgggggc																										TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr7:47384376_47384388delGCTGGGCTGCTCA	uc003tnv.2	-	20	2982_2994	c.2615_2627delTGAGCAGCCCAGC	c.(2614-2628)CTGAGCAGCCCAGCCfs	p.L872fs	TNS3_uc003tnw.2_Frame_Shift_Del_p.L872fs	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	872_876						focal adhesion	protein binding			ovary(4)	4						GTGCTGACTGGCTGGGCTGCTCAGCGGGGGCTC	0.61													---	---	---								-	47384388	-	-	47384376	7	5	175	1	0	1	0	1	0	0	0	0	16410	1203	42	0	1758	0	TNS3	7	47384376	Frame_Shift_Del	DEL	GCTGGGCTGCTCA	TCGA-CV-5440-01A-01D-1512-08	15535680	47384376	111754287	33	32747											
LIMK1	3984	broad.mit.edu	37	chr7	73521402	73521402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggctccccggcctcccagcGcaaggacctgggtcgctctg	4	6	14	17	3	1	0	0	0	1	0	4	1	3	1	5	4	1	3	5	4	1	0			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr7:73521402G>A	uc003uaa.1	+	8	1109	c.944G>A	c.(943-945)CGC>CAC	p.R315H	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.R281H|LIMK1_uc003uac.1_Missense_Mutation_p.R107H	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	315					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				GCCTCCCAGCGCAAGGACCTG	0.706													11	15					0	0	0	0	A	73521402	A	A	73521402	3	1	175	1	0	0	0	0	1	0	0	0	8842	1087	38	1	974	1	LIMK1	7	73521402	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	26137026	73521402	85617261	34	32748											
MUC17	140453	broad.mit.edu	37	chr7	100677236	100677236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctactgaagtcagttcatctCctacacctgctgaaggtacc	10	11	7	13	0	3	2	2	2	1	0	4	2	3	2	3	1	4	3	3	1	5	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr7:100677236C>T	uc003uxp.1	+	3	2592	c.2539C>T	c.(2539-2541)CCT>TCT	p.P847S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	847	Extracellular (Potential).|12.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTTCATCTCCTACACCTGC	0.502													108	197					0	0	0	0	T	100677236	T	T	100677236	3	4	175	1	0	0	0	0	1	0	0	0	10027	855	30	2	2549	2	MUC17	7	100677236	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	27155834	100677236	58461427	35	32749											
RNF133	168433	broad.mit.edu	37	chr7	122338572	122338572	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggaacacctggttgccagtaCctggaacgttatagatgatc	11	10	11	9	1	0	2	0	1	0	1	1	4	0	4	3	3	4	3	3	3	5	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr7:122338572C>A	uc003vkj.1	-	1	637	c.401G>T	c.(400-402)GGT>GTT	p.G134V	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	134	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						GTTGCCAGTACCTGGAACGTT	0.428													19	60					6.94344e-10	7.65452e-10	1	0	A	122338572	A	A	122338572	3	1	175	1	0	0	0	0	1	0	0	0	13504	507	18	4	733	4	RNF133	7	122338572	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	21661336	122338572	36800091	36	32750											
CALU	813	broad.mit.edu	37	chr7	128407640	128407640	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaagagaccaaagactggatCcttccctcagactatgatca	14	8	8	11	0	2	4	2	1	0	3	4	7	4	5	3	1	0	0	3	1	3	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr7:128407640C>T	uc003vns.2	+	6	926	c.774C>T	c.(772-774)ATC>ATT	p.I258I	CALU_uc003vnq.2_Silent_p.I258I|CALU_uc003vnr.2_Silent_p.I258I	NM_001130674	NP_001124146	O43852	CALU_HUMAN	calumenin isoform b precursor	258	EF-hand 5.				platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding				0						AAGACTGGATCCTTCCCTCAG	0.502													18	10					0	0	0	0	T	128407640	T	T	128407640	2	4	175	1	0	0	0	0	0	0	0	1	2606	845	30	2		2	CALU	7	128407640	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08	6069068	128407640	30731023	37	32751											
ADAM9	8754	broad.mit.edu	37	chr8	38880809	38880809	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcgggaaaagtttcttatCacacgtcggagacatgacag	12	9	12	8	3	2	2	1	1	1	1	3	4	2	3	0	3	0	1	0	3	3	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr8:38880809C>G	uc003xmr.2	+	9	957	c.879C>G	c.(877-879)ATC>ATG	p.I293M	ADAM9_uc011lcf.1_RNA|ADAM9_uc011lcg.1_RNA|ADAM9_uc010lwr.2_RNA	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9 isoform 1	293	Extracellular (Potential).|Peptidase M12B.				activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			AGTTTCTTATCACACGTCGGA	0.363													7	33					0	0	0	0	G	38880809	G	G	38880809	3	3	175	1	0	0	0	0	1	0	0	0	253	816	29	2	913	2	ADAM9	8	38880809	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08		38880809	107483213	38	32752											
ADAM32	203102	broad.mit.edu	37	chr8	39009051	39009051	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaaccaatggatgacaacaTttttataagtgaaaaagtga	19	10	7	5	0	0	3	0	3	0	0	0	4	0	4	1	1	2	0	1	1	7	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr8:39009051T>C	uc003xmt.3	+	6	754	c.509T>C	c.(508-510)ATT>ACT	p.I170T	ADAM32_uc011lch.1_Missense_Mutation_p.I177T|ADAM32_uc003xmu.3_Missense_Mutation_p.I170T	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	170					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			GATGACAACATTTTTATAAGT	0.254													9	15					0	0	0	0	C	39009051	C	C	39009051	3	2	175	1	0	0	0	0	1	0	0	0	249	1493	52	5	531	5	ADAM32	8	39009051	Missense_Mutation	SNP	T	TCGA-CV-5440-01A-01D-1512-08	128242	39009051	107354971	39	32753											
PRKDC	5591	broad.mit.edu	37	chr8	48848436	48848436	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcaccacgaggtgctccaGaactggagtatacacctcag	12	7	9	13	1	2	1	2	0	0	1	3	3	3	2	3	2	3	2	3	2	3	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr8:48848436G>C	uc003xqi.2	-	13	1360	c.1303C>G	c.(1303-1305)CTG>GTG	p.L435V	PRKDC_uc003xqj.2_Missense_Mutation_p.L435V|PRKDC_uc011ldh.1_Missense_Mutation_p.L435V	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	435					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGGTGCTCCAGAACTGGAGTA	0.433								NHEJ					7	11					0	0	0	0	C	48848436	C	C	48848436	3	2	175	1	0	0	0	0	1	0	0	0	12583	933	33	2	11378	2	PRKDC	8	48848436	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	9839385	48848436	97515586	40	32754											
TOX	9760	broad.mit.edu	37	chr8	59852094	59852094	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcactttccaggcttggacCagggtaggactgtgaaaaga	11	10	12	8	0	1	2	1	1	0	1	2	4	2	4	2	4	0	2	2	4	3	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr8:59852094C>A	uc003xtw.1	-	3	399	c.178G>T	c.(178-180)GGT>TGT	p.G60C		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	60						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				AGGCTTGGACCAGGGTAGGAC	0.423													13	26					7.93312e-07	8.53977e-07	1	0	A	59852094	A	A	59852094	3	1	175	1	0	0	0	0	1	0	0	0	16444	594	21	4	1430	4	TOX	8	59852094	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	11003658	59852094	86511928	41	32755											
CSPP1	79848	broad.mit.edu	37	chr8	68092140	68092140	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcttgaaaaactcattattgGaatctgatagtgcttttatt	12	18	6	5	0	3	2	1	2	2	0	3	3	3	3	0	1	2	1	0	1	6	7			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr8:68092140G>T	uc003xxi.2	+	28	3320	c.3289G>T	c.(3289-3291)GAA>TAA	p.E1097*	ARFGEF1_uc003xxl.1_Intron|CSPP1_uc003xxj.2_Nonsense_Mutation_p.E1062*|CSPP1_uc003xxk.2_Nonsense_Mutation_p.E717*|CSPP1_uc010lyw.2_Nonsense_Mutation_p.E157*	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	1097						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			CTCATTATTGGAATCTGATAG	0.274													15	33					4.14922e-12	4.68708e-12	1	0	T	68092140	T	T	68092140	4	4	175	1	0	0	0	0	0	1	0	0	3979	1175	41	2	3399	2	CSPP1	8	68092140	Nonsense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	8240046	68092140	78271882	42	32756											
RIMS2	9699	broad.mit.edu	37	chr8	104928744	104928744	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctgaaccacaagtagaacTtgtagtttcaaggcctattg	13	11	8	9	0	1	2	1	1	0	1	1	2	1	2	3	1	2	3	3	1	7	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr8:104928744T>C	uc003yls.2	+	6	1590	c.1349T>C	c.(1348-1350)CTT>CCT	p.L450P	RIMS2_uc003ylp.2_Missense_Mutation_p.L672P|RIMS2_uc003ylw.2_Missense_Mutation_p.L480P|RIMS2_uc003ylq.2_Missense_Mutation_p.L480P|RIMS2_uc003ylr.2_Missense_Mutation_p.L527P|RIMS2_uc003ylt.2_Missense_Mutation_p.L73P|RIMS2_uc003ylu.1_Missense_Mutation_p.L63P|RIMS2_uc003ylv.1_Missense_Mutation_p.L63P	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	750	PDZ.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CAAGTAGAACTTGTAGTTTCA	0.348										HNSCC(12;0.0054)			40	19					0	0	0	0	C	104928744	C	C	104928744	3	2	175	1	0	0	0	0	1	0	0	0	13433	1609	56	5	2171	5	RIMS2	8	104928744	Missense_Mutation	SNP	T	TCGA-CV-5440-01A-01D-1512-08	36836604	104928744	41435278	43	32757											
RIMS2	9699	broad.mit.edu	37	chr8	105001535	105001535	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagatcttgttgttttagtcGgaatgtggaacaggggcttc	8	15	13	5	1	1	1	0	0	1	1	3	3	1	3	0	4	1	3	0	4	4	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr8:105001535G>A	uc003yls.2	+	15	2505	c.2264G>A	c.(2263-2265)CGG>CAG	p.R755Q	RIMS2_uc003ylp.2_Missense_Mutation_p.R977Q|RIMS2_uc003ylw.2_Missense_Mutation_p.R769Q|RIMS2_uc003ylq.2_Missense_Mutation_p.R769Q|RIMS2_uc003ylr.2_Missense_Mutation_p.R816Q	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1039					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGTTTTAGTCGGAATGTGGAA	0.383										HNSCC(12;0.0054)			18	84					0	0	0	0	A	105001535	A	A	105001535	3	1	175	1	0	0	0	0	1	0	0	0	13433	1116	39	1	3122	1	RIMS2	8	105001535	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	72791	105001535	41362487	44	32758											
EIF3H	8667	broad.mit.edu	37	chr8	117668121	117668121	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaaggctgagcaattcatgTttatctgcaacagctgactt	11	12	9	9	0	2	2	1	2	1	0	2	2	2	2	0	1	4	6	0	1	4	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr8:117668121T>C	uc003yoa.2	-	5	707	c.681A>G	c.(679-681)AAA>AAG	p.K227K	EIF3H_uc003yob.2_Silent_p.K241K	NM_003756	NP_003747	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3,	227					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					GCAATTCATGTTTATCTGCAA	0.378													29	78					0	0	0	0	C	117668121	C	C	117668121	2	2	175	1	0	0	0	0	0	0	0	1	5042	1722	60	5		5	EIF3H	8	117668121	Silent	SNP	T	TCGA-CV-5440-01A-01D-1512-08	12666586	117668121	28695901	45	32759											
DERL1	79139	broad.mit.edu	37	chr8	124042859	124042859	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acatacctgtttcaagtcgcGtagaatactgatataagaaa	16	11	7	7	2	1	3	1	1	0	2	2	3	1	3	1	0	2	2	1	0	8	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr8:124042859G>A	uc003ypl.2	-	2	537	c.251C>T	c.(250-252)ACG>ATG	p.T84M	DERL1_uc003ypm.2_Missense_Mutation_p.T84M|DERL1_uc011lif.1_Intron|DERL1_uc003ypn.2_Missense_Mutation_p.T84M	NM_024295	NP_077271	Q9BUN8	DERL1_HUMAN	Der1-like domain family, member 1 isoform a	84	Cytoplasmic (Potential).				endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|intracellular transport of viral proteins in host cell|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	MHC class I protein binding|receptor activity				0	Lung NSC(37;1.06e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			TTCAAGTCGCGTAGAATACTG	0.373													7	49					0	0	0	0	A	124042859	A	A	124042859	3	1	175	1	0	0	0	0	1	0	0	0	4468	1145	40	1	532	1	DERL1	8	124042859	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	6374738	124042859	22321163	46	32760											
KIAA0196	9897	broad.mit.edu	37	chr8	126062854	126062854	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgcagggcaaaggcaacGcgcttcacaagctctttcct	10	9	9	13	2	2	0	1	0	1	0	3	0	3	0	1	2	3	5	1	2	4	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr8:126062854G>A	uc003yrt.2	-	18	2480	c.2151C>T	c.(2149-2151)CGC>CGT	p.R717R	KIAA0196_uc011lir.1_Silent_p.R569R|KIAA0196_uc003yru.1_Silent_p.R291R	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	717					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CAAAGGCAACGCGCTTCACAA	0.483													10	58					0	0	0	0	A	126062854	A	A	126062854	2	1	175	1	0	0	0	0	0	0	0	1	8200	1074	38	1		1	KIAA0196	8	126062854	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08	2019995	126062854	20301168	47	32761											
SMARCA2	6595	broad.mit.edu	37	chr9	2039777	2039779	+	In_Frame_Del	DEL	CAG	-	-																															agcaacaacagcagcagcaaCagcagcagcagcagcagcag																								rs113070757	byFrequency	TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:2039777_2039779delCAG	uc003zhc.2	+	4	766_768	c.667_669delCAG	c.(667-669)CAGdel	p.Q238del	SMARCA2_uc003zhd.2_In_Frame_Del_p.Q238del|SMARCA2_uc010mha.2_In_Frame_Del_p.Q229del	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	238	Poly-Gln.			Missing (in Ref. 1; CAA51407).	chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		gcagcagcaacagcagcagcagc	0.271													---	---	---								-	2039779	-	-	2039777	7	5	175	1	0	1	0	1	0	0	0	0	14833	479	17	0	677	0	SMARCA2	9	2039777	In_Frame_Del	DEL	CAG	TCGA-CV-5440-01A-01D-1512-08		2039777	139173654	48	32762											
CDKN2A	1029	broad.mit.edu	37	chr9	21971111	21971111	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccctcccgggcagcgtcgtGcacgggtcgggtgagagtgg	4	6	19	12	5	0	1	0	1	0	1	3	2	1	1	2	4	2	2	2	4	0	0	rs121913385		TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:21971111G>A	uc003zpk.2	-	2	459	c.247C>T	c.(247-249)CAC>TAC	p.H83Y	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.A138V	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	83	ANK 3.		H -> N (in a lung tumor).|H -> Y (in a pancreas and a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.H83Y(28)|p.?(13)|p.H83fs*2(2)|p.H83P(2)|p.H83N(1)|p.V82fs*62(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.A138V(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)|p.H83R(1)|p.H83Q(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGCGTCGTGCACGGGTCGG	0.741	H83Y(CALU3_LUNG)|H83Y(JHH2_LIVER)|H83Y(HS944T_SKIN)|H83Y(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|H83Y(OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			31	7					0	0	0	0	A	21971111	A	A	21971111	3	1	175	1	0	0	0	0	1	0	0	0	3176	1319	46	4	231	4	CDKN2A	9	21971111	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	19931334	21971111	119242320	49	32763											
SMC5	23137	broad.mit.edu	37	chr9	72933828	72933829	+	Frame_Shift_Ins	INS	-	A	A																															aagaaggagcttcttgagagINSaaaaaccaagaaaagacaac																										TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:72933828_72933829insA	uc004ahr.2	+	15	2216_2217	c.2099_2100insA	c.(2098-2100)AGAfs	p.R700fs	uc004ahs.1_5'Flank	NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	700	Potential.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						CTTCTTGAGAGAAAAACCAAGA	0.406													---	---	---								A	72933829	A	A	72933828	7	5	175	1	0	1	1	0	0	0	0	0	14850	942	33	0	2157	0	SMC5	9	72933828	Frame_Shift_Ins	INS	-	TCGA-CV-5440-01A-01D-1512-08	50962717	72933828	68279603	50	32764											
TMEM2	23670	broad.mit.edu	37	chr9	74327069	74327069	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggaattcttcatgaggaagCcaattgcactgctgtaccta	12	11	9	9	0	2	1	1	1	1	0	2	3	2	3	2	2	4	3	2	2	5	5			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:74327069C>A	uc011lsa.1	-	16	3239	c.2699G>T	c.(2698-2700)GGC>GTC	p.G900V	TMEM2_uc010mos.2_Missense_Mutation_p.G837V|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	900						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CATGAGGAAGCCAATTGCACT	0.428													54	9					7.77372e-23	9.00374e-23	1	0	A	74327069	A	A	74327069	3	1	175	1	0	0	0	0	1	0	0	0	16187	739	26	4	1488	4	TMEM2	9	74327069	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	1393241	74327069	66886362	51	32765											
TLE4	7091	broad.mit.edu	37	chr9	82333859	82333859	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcagccacccaggcaataaGagtcctgtctcccagctcga	11	7	8	15	1	2	1	1	0	1	1	5	2	3	1	4	1	2	2	4	1	2	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:82333859G>A	uc004ald.2	+	16	2487	c.1638G>A	c.(1636-1638)AAG>AAA	p.K546K	TLE4_uc004alc.2_Silent_p.K521K|TLE4_uc010mpr.2_Silent_p.K400K|TLE4_uc004ale.2_Silent_p.K158K|TLE4_uc011lsq.1_Silent_p.K489K|TLE4_uc010mps.2_Silent_p.K445K|TLE4_uc004alf.2_Silent_p.K460K	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment								p.R546C(1)		lung(2)|ovary(1)|breast(1)|skin(1)	5						CAGGCAATAAGAGTCCTGTCT	0.542													9	55					0	0	0	0	A	82333859	A	A	82333859	2	1	175	1	0	0	0	0	0	0	0	1	16007	933	33	2		2	TLE4	9	82333859	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08	8006790	82333859	58879572	52	32766											
SYK	6850	broad.mit.edu	37	chr9	93641137	93641137	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaattttgtgcacagagatCtggctgcaagaaatgtgttg	11	12	12	6	0	1	2	0	0	1	2	1	3	1	2	0	1	2	5	0	1	3	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:93641137C>T	uc004aqz.2	+	11	1688	c.1483C>T	c.(1483-1485)CTG>TTG	p.L495L	SYK_uc004ara.2_Silent_p.L472L|SYK_uc004arb.2_Silent_p.L472L|SYK_uc004arc.2_Silent_p.L495L|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	495	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						GCACAGAGATCTGGCTGCAAG	0.433			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								16	64					0	0	0	0	T	93641137	T	T	93641137	2	4	175	1	0	0	0	0	0	0	0	1	15504	912	32	2		2	SYK	9	93641137	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08	11307278	93641137	47572294	53	32767											
ZNF510	22869	broad.mit.edu	37	chr9	99521412	99521412	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgaatggtttctctcccGtgtgagttttctgatgttga	6	19	10	6	1	2	4	0	4	2	0	4	4	3	4	1	1	0	3	1	1	1	5	rs141866339	by1000genomes	TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:99521412G>A	uc004awn.1	-	6	1889	c.1700C>T	c.(1699-1701)ACG>ATG	p.T567M	ZNF510_uc004awo.1_Missense_Mutation_p.T567M	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	567					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				TTTCTCTCCCGTGTGAGTTTT	0.418													33	42					0	0	0	0	A	99521412	A	A	99521412	3	1	175	1	0	0	0	0	1	0	0	0	18021	1145	40	1	355	1	ZNF510	9	99521412	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	5880275	99521412	41692019	54	32768											
TBC1D2	55357	broad.mit.edu	37	chr9	100971314	100971314	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagcggccgatccacagcctCgaggcccagcaggtggtggg	7	4	16	14	3	0	0	0	0	0	0	2	2	1	0	4	5	3	1	4	5	0	0			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:100971314C>T	uc011lvb.1	-	9	1966	c.1786G>A	c.(1786-1788)GAG>AAG	p.E596K	TBC1D2_uc004ayp.2_Missense_Mutation_p.E136K|TBC1D2_uc004ayq.2_Missense_Mutation_p.E596K|TBC1D2_uc004ayr.2_Missense_Mutation_p.E378K|TBC1D2_uc004ayo.3_Missense_Mutation_p.E596K	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	596						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		TCCACAGCCTCGAGGCCCAGC	0.647													11	212					0	0	0	0	T	100971314	T	T	100971314	3	4	175	1	0	0	0	0	1	0	0	0	15674	893	31	1	987	1	TBC1D2	9	100971314	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	1449902	100971314	40242117	55	32769											
COL15A1	1306	broad.mit.edu	37	chr9	101788189	101788189	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcactgatgttccccagggcCctgagggacagcctggagtt	7	9	13	12	0	1	2	1	2	0	0	2	4	2	4	4	3	1	2	4	3	0	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:101788189C>G	uc004azb.1	+	16	2190	c.1984C>G	c.(1984-1986)CCT>GCT	p.P662A		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	662	Triple-helical region 2 (COL2).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TCCCCAGGGCCCTGAGGGACA	0.577													10	3					0	0	0	0	G	101788189	G	G	101788189	3	3	175	1	0	0	0	0	1	0	0	0	3687	623	22	4	2046	4	COL15A1	9	101788189	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	816875	101788189	39425242	56	32770											
SNX30	401548	broad.mit.edu	37	chr9	115598539	115598539	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatagcattgctgaccagaAtgggcgagtcagtcaagcac	12	7	13	9	1	2	2	2	1	0	1	2	4	2	3	1	2	3	3	1	2	3	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:115598539A>G	uc004bgj.3	+	5	812	c.664A>G	c.(664-666)ATG>GTG	p.M222V	SNX30_uc004bgi.3_5'Flank	NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	222					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						GCTGACCAGAATGGGCGAGTC	0.507													100	20					0	0	0	0	G	115598539	G	G	115598539	3	3	175	1	0	0	0	0	1	0	0	0	14964	101	4	5	682	5	SNX30	9	115598539	Missense_Mutation	SNP	A	TCGA-CV-5440-01A-01D-1512-08	13810350	115598539	25614892	57	32771											
ALAD	210	broad.mit.edu	37	chr9	116150610	116150610	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcagccactgcagcagctgCggtgtgtagtaggtgatgat	8	11	14	8	1	1	2	1	2	0	0	1	2	1	2	1	2	5	5	1	2	2	3	rs35581515		TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:116150610C>T	uc011lxf.1	-	12	1165	c.963G>A	c.(961-963)CCG>CCA	p.P321P	ALAD_uc011lxe.1_Silent_p.P304P|ALAD_uc004bhl.3_Silent_p.P350P	NM_000031	NP_000022	P13716	HEM2_HUMAN	delta-aminolevulinic acid dehydratase	321					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding				0					Aminolevulinic acid(DB00855)	GCAGCAGCTGCGGTGTGTAGT	0.532													4	115					0	0	0	0	T	116150610	T	T	116150610	2	4	175	1	0	0	0	0	0	0	0	1	483	755	27	1		1	ALAD	9	116150610	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08	552071	116150610	25062821	58	32772											
DENND1A	57706	broad.mit.edu	37	chr9	126319866	126319866	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caccggctcgattttcagagCgtttcggtagctaccgaaga	9	10	11	11	5	1	2	1	0	0	2	3	4	1	2	2	2	3	4	2	2	3	5			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:126319866C>A	uc004bnz.1	-	13	1209	c.976G>T	c.(976-978)GCT>TCT	p.A326S	DENND1A_uc011lzl.1_Intron|DENND1A_uc004bny.1_Missense_Mutation_p.A143S|DENND1A_uc011lzm.1_Missense_Mutation_p.A294S|DENND1A_uc004boa.1_Missense_Mutation_p.A326S|DENND1A_uc004bob.1_Missense_Mutation_p.A296S|DENND1A_uc004boc.2_Missense_Mutation_p.A294S	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	326	dDENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						ATTTTCAGAGCGTTTCGGTAG	0.547													11	20					4.68919e-08	5.10787e-08	1	0	A	126319866	A	A	126319866	3	1	175	1	0	0	0	0	1	0	0	0	4448	768	27	3	2200	3	DENND1A	9	126319866	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	10169256	126319866	14893565	59	32773											
ABO	28	broad.mit.edu	37	chr9	136132863	136132863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaactgctcgttgaggatgtCgatgttgaatgtgccctccc	7	12	12	10	2	0	2	0	2	0	0	3	5	1	3	2	1	3	3	2	1	2	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:136132863C>T	uc004cda.1	-	7	332	c.307G>A	c.(307-309)GAC>AAC	p.D103N	ABO_uc010naf.1_5'UTR|ABO_uc011mcz.1_Intron|ABO_uc010nag.1_5'UTR	NM_020469	NP_065202	P16442	BGAT_HUMAN	ABO blood group (alpha	103	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		TTGAGGATGTCGATGTTGAAT	0.552													3	45					0	0	0	0	T	136132863	T	T	136132863	3	4	175	1	0	0	0	0	1	0	0	0	97	871	31	1	765	1	ABO	9	136132863	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	9812997	136132863	5080568	60	32774											
C9orf172	389813	broad.mit.edu	37	chr9	139741083	139741083	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caccgcgctttctcgcgcatCgcgcgtgtcggcttcctgtc	2	11	11	17	8	1	0	0	0	1	0	6	0	2	0	2	1	0	3	2	1	0	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr9:139741083C>G	uc011meh.1	+	1	2217	c.2217C>G	c.(2215-2217)ATC>ATG	p.I739M	PHPT1_uc004cjp.2_5'Flank|PHPT1_uc011mei.1_5'Flank|PHPT1_uc004cjq.3_5'Flank	NM_001080482	NP_001073951	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	739											0						TCTCGCGCATCGCGCGTGTCG	0.706													3	13					0	0	0	0	G	139741083	G	G	139741083	3	3	175	1	0	0	0	0	1	0	0	0	2483	874	31	3	2219	3	C9orf172	9	139741083	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	3608220	139741083	1472348	61	32775											
RET	5979	broad.mit.edu	37	chr10	43601966	43601966	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggaacactggcccaacgAgacctcggtccaggccaacg	10	4	13	14	3	0	1	0	0	0	1	2	3	1	2	4	5	3	0	4	5	3	0			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:43601966A>T	uc001jal.2	+	5	1200	c.1010A>T	c.(1009-1011)GAG>GTG	p.E337V	RET_uc001jak.1_Missense_Mutation_p.E337V|RET_uc010qez.1_Missense_Mutation_p.E83V	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	337	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	TGGCCCAACGAGACCTCGGTC	0.652		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				6	11					0	0	0	0	T	43601966	T	T	43601966	3	4	175	1	0	0	0	0	1	0	0	0	13300	304	11	5	1028	5	RET	10	43601966	Missense_Mutation	SNP	A	TCGA-CV-5440-01A-01D-1512-08		43601966	91932781	62	32776											
FAM21C	253725	broad.mit.edu	37	chr10	46222872	46222872	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttttcgctgcagatgaaccGgacgacccccgaccaggagc	9	7	11	14	4	0	2	0	1	0	1	1	6	0	4	4	2	3	2	4	2	1	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:46222872G>C	uc001jcu.2	+	2	110	c.11G>C	c.(10-12)CGG>CCG	p.R4P	FAM21C_uc001jcs.1_Missense_Mutation_p.R4P|FAM21C_uc001jct.2_Missense_Mutation_p.R4P|FAM21C_uc010qfi.1_Missense_Mutation_p.R4P	NM_015262	NP_056077	A8K5W5	A8K5W5_HUMAN	hypothetical protein LOC253725	4										ovary(1)	1						CAGATGAACCGGACGACCCCC	0.721													3	13					0	0	0	0	C	46222872	C	C	46222872	3	2	175	1	0	0	0	0	1	0	0	0	5570	1116	39	3	17	3	FAM21C	10	46222872	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	2620906	46222872	89311875	63	32777											
ARID5B	84159	broad.mit.edu	37	chr10	63851485	63851485	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccatcagtgattcagcacGtccagagtttcagaagcaag	12	8	11	10	1	3	3	3	1	0	2	4	3	4	3	2	1	2	3	2	1	2	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:63851485G>A	uc001jlt.1	+	10	2289	c.2263G>A	c.(2263-2265)GTC>ATC	p.V755I		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	755					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GATTCAGCACGTCCAGAGTTT	0.512													5	90					0	0	0	0	A	63851485	A	A	63851485	3	1	175	1	0	0	0	0	1	0	0	0	922	1145	40	1	2301	1	ARID5B	10	63851485	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	17628613	63851485	71683262	64	32778											
ZNF365	22891	broad.mit.edu	37	chr10	64425946	64425946	+	Frame_Shift_Del	DEL	C	-	-																															cttcttacactaggacaactCcaaaattgtgtgattggtaa																										TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:64425946delC	uc001jmd.1	+	6	874	c.540delC	c.(538-540)CTCfs	p.L180fs	ZNF365_uc001jmc.2_Frame_Shift_Del_p.L426fs|ZNF365_uc001jme.1_RNA|ZNF365_uc001jmf.1_RNA|ZNF365_uc009xpg.1_Intron	NM_199452	NP_955524	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform D	180										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					TAGGACAACTCCAAAATTGTG	0.408													---	---	---								-	64425946	-	-	64425946	7	5	175	1	0	1	0	1	0	0	0	0	17936	842	30	0	2036	0	ZNF365	10	64425946	Frame_Shift_Del	DEL	C	TCGA-CV-5440-01A-01D-1512-08	574461	64425946	71108801	65	32779											
TTC18	118491	broad.mit.edu	37	chr10	75051479	75051480	+	Missense_Mutation	DNP	CC	TT	TT																															ttctgcttgctcatagttctCcaacaggacagccaggacac																										TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:75051479_75051480CC>TT	uc009xrc.2	-	19	2269_2270	c.2148_2149GG>AA	c.(2146-2151)TTGGAG>TTAAAG	p.E717K	TTC18_uc001jty.2_Missense_Mutation_p.E717K|TTC18_uc001jtv.3_5'Flank|TTC18_uc001jtw.3_5'Flank|TTC18_uc001jtx.2_Missense_Mutation_p.E98K	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	717	TPR 3.						binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					TCATAGTTCTCCAACAGGACAG	0.406													4	20					0	0	0	0	TT	75051480	TT	TT	75051479	3	4	175	1	0	0	0	0	1	0	0	0	16753	864	30	2	1256	2	TTC18	10	75051479	Missense_Mutation	DNP	CC	TCGA-CV-5440-01A-01D-1512-08	10625533	75051479	60483268	66	32780											
PTEN	5728	broad.mit.edu	37	chr10	89624189	89624189	+	Translation_Start_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaccagcagcttctgccatCtctctcctcctttttcttca	5	15	3	18	0	5	0	1	0	4	0	8	0	6	0	5	0	3	2	5	0	0	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:89624189C>G	uc001kfb.2	+	2	994	c.-37C>G	c.(-39--35)ATCTC>ATGTC		KILLIN_uc009xti.2_5'Flank	NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTTCTGCCATCTCTCTCCTCC	0.542		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			13	17					0	0	0	0	G	89624189	G	G	89624189	1	3	175	1	0	0	0	0	0	0	0	0	12800	928	32	2		2	PTEN	10	89624189	Translation_Start_Site	SNP	C	TCGA-CV-5440-01A-01D-1512-08	14572710	89624189	45910558	67	32781											
CNNM1	26507	broad.mit.edu	37	chr10	101117299	101117299	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggccattgtccagcgggTgaataatgagggagaagggg	10	7	17	7	1	0	3	0	2	0	1	1	4	1	3	3	5	1	0	3	5	3	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:101117299T>A	uc001kpp.3	+	2	1893	c.1604T>A	c.(1603-1605)GTG>GAG	p.V535E	CNNM1_uc009xwe.2_Missense_Mutation_p.V535E|CNNM1_uc010qpi.1_Missense_Mutation_p.V535E|CNNM1_uc009xwf.2_Missense_Mutation_p.V535E|CNNM1_uc009xwg.2_5'Flank	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	535	CBS 2.				ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		GTCCAGCGGGTGAATAATGAG	0.433													6	13					0	0	0	0	A	101117299	A	A	101117299	3	1	175	1	0	0	0	0	1	0	0	0	3627	1696	59	5	1610	5	CNNM1	10	101117299	Missense_Mutation	SNP	T	TCGA-CV-5440-01A-01D-1512-08	11493110	101117299	34417448	68	32782											
DNMBP	23268	broad.mit.edu	37	chr10	101639864	101639864	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggatttagggatgcactgaGagttccttggtcacattctt	8	14	11	8	1	2	1	1	1	1	1	3	4	3	3	1	3	1	2	1	3	1	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:101639864G>C	uc001kqj.2	-	16	4344	c.4252C>G	c.(4252-4254)CTC>GTC	p.L1418V	DNMBP_uc010qpl.1_Missense_Mutation_p.L354V|DNMBP_uc001kqg.2_Missense_Mutation_p.L706V|DNMBP_uc001kqh.2_Missense_Mutation_p.L1050V	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1418	Ser-rich.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		GATGCACTGAGAGTTCCTTGG	0.537													16	78					0	0	0	0	C	101639864	C	C	101639864	3	2	175	1	0	0	0	0	1	0	0	0	4696	942	33	2	489	2	DNMBP	10	101639864	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	522565	101639864	33894883	69	32783											
DNMBP	23268	broad.mit.edu	37	chr10	101715220	101715220	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccctccttttctaaggtctCacaggtaggacggtgtcgag	7	11	12	11	2	2	0	1	0	2	0	5	2	3	1	2	4	0	1	2	4	2	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:101715220C>G	uc001kqj.2	-	4	2103	c.2011G>C	c.(2011-2013)GAG>CAG	p.E671Q	NCRNA00093_uc001kqk.1_Intron	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	671					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TCTAAGGTCTCACAGGTAGGA	0.597													9	32					0	0	0	0	G	101715220	G	G	101715220	3	3	175	1	0	0	0	0	1	0	0	0	4696	835	29	2	2778	2	DNMBP	10	101715220	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	75356	101715220	33819527	70	32784											
DNMBP	23268	broad.mit.edu	37	chr10	101715433	101715433	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctttctcctttccggcagctCctgctcggtgattaactttg	4	16	8	13	2	1	1	0	1	1	0	5	1	3	1	3	2	3	3	3	2	1	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:101715433C>G	uc001kqj.2	-	4	1890	c.1798G>C	c.(1798-1800)GAG>CAG	p.E600Q	NCRNA00093_uc001kqk.1_RNA	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	600					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TCCGGCAGCTCCTGCTCGGTG	0.502													9	36					0	0	0	0	G	101715433	G	G	101715433	3	3	175	1	0	0	0	0	1	0	0	0	4696	864	30	2	2991	2	DNMBP	10	101715433	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	213	101715433	33819314	71	32785											
SMC3	9126	broad.mit.edu	37	chr10	112343699	112343701	+	In_Frame_Del	DEL	AAG	-	-																															attcaacagtgtgaaagagaAagaagaacgaggaattgcta																										TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:112343699_112343701delAAG	uc001kze.2	+	12	1196_1198	c.1070_1072delAAG	c.(1069-1074)AAAGAA>AAA	p.E359del		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	359					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GTGAAAGAGAAAGAAGAACGAGG	0.36													---	---	---								-	112343701	-	-	112343699	7	5	175	1	0	1	0	1	0	0	0	0	14848	14	1	0	1116	0	SMC3	10	112343699	In_Frame_Del	DEL	AAG	TCGA-CV-5440-01A-01D-1512-08	10628266	112343699	23191048	72	32786											
TIAL1	7073	broad.mit.edu	37	chr10	121339445	121339445	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaattgagatggaagaacgtAccagtttgttataaaaagat	18	11	9	3	1	0	3	0	1	0	3	0	5	0	4	1	1	2	3	1	1	8	5			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr10:121339445A>T	uc001lei.1	-	6	1011	c.447_splice	c.e6+1	p.L149_splice	TIAL1_uc001leh.1_Splice_Site_p.L127_splice|TIAL1_uc001lej.1_Splice_Site_p.L166_splice|TIAL1_uc001lek.1_Splice_Site_p.L26_splice|TIAL1_uc009xzi.1_Splice_Site_p.L18_splice|TIAL1_uc010qtb.1_Splice_Site_p.L26_splice	NM_003252	NP_003243	Q01085	TIAR_HUMAN	TIA-1 related protein isoform 1						apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		GGAAGAACGTACCAGTTTGTT	0.313													4	6					0	0	0	0	T	121339445	T	T	121339445	5	4	175	1	0	0	0	0	0	0	1	0	15955	405	14	5	706	5	TIAL1	10	121339445	Splice_Site	SNP	A	TCGA-CV-5440-01A-01D-1512-08	8995746	121339445	14195302	73	32787											
MICALCL	84953	broad.mit.edu	37	chr11	12379876	12379876	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagaaggatctaaacgaagaGcaagaagtattcaccgagct	17	6	11	7	2	2	3	1	0	1	3	2	7	2	4	1	1	3	3	1	1	7	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr11:12379876G>A	uc001mkg.1	+	9	2229	c.1938G>A	c.(1936-1938)GAG>GAA	p.E646E		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	646	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		TAAACGAAGAGCAAGAAGTAT	0.473													34	72					0	0	0	0	A	12379876	A	A	12379876	2	1	175	1	0	0	0	0	0	0	0	1	9625	962	34	4		4	MICALCL	11	12379876	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08		12379876	122626640	74	32788											
LRP4	4038	broad.mit.edu	37	chr11	46911618	46911618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgctcttggtgtgccagtCtgtccagtacaggctgtctt	5	14	12	10	0	3	0	0	0	3	0	4	1	4	0	2	2	3	3	2	2	1	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr11:46911618C>T	uc001ndn.3	-	15	2115	c.1969G>A	c.(1969-1971)GAC>AAC	p.D657N		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	657	Extracellular (Potential).|LDL-receptor class B 5.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GTGTGCCAGTCTGTCCAGTAC	0.517											OREG0020948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	89					0	0	0	0	T	46911618	T	T	46911618	3	4	175	1	0	0	0	0	1	0	0	0	9009	913	32	2	3844	2	LRP4	11	46911618	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	34531742	46911618	88094898	75	32789											
OR4C12	283093	broad.mit.edu	37	chr11	50003589	50003589	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaatagttgcatgaagaaatCctcccacccaggccactgcc	12	7	8	14	0	0	2	0	1	0	1	2	3	2	2	5	1	2	2	5	1	4	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr11:50003589C>A	uc010ria.1	-	1	449	c.449G>T	c.(448-450)GGA>GTA	p.G150V		NM_001005270	NP_001005270	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ATGAAGAAATCCTCCCACCCA	0.498													62	100					5.52965e-18	6.28525e-18	1	0	A	50003589	A	A	50003589	3	1	175	1	0	0	0	0	1	0	0	0	11100	855	30	2	484	2	OR4C12	11	50003589	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	3091971	50003589	85002927	76	32790											
ADRBK1	156	broad.mit.edu	37	chr11	67044773	67044773	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcatgcagaagtacctggaGgaccggggcgaggtgacctt	9	7	16	9	2	1	2	1	1	0	1	1	5	1	4	3	5	2	2	3	5	2	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr11:67044773G>A	uc009yrn.1	+	2	410	c.144G>A	c.(142-144)GAG>GAA	p.E48E	ADRBK1_uc009yrm.1_Silent_p.E48E	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	48	N-terminal.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	AGTACCTGGAGGACCGGGGCG	0.617													4	162					0	0	0	0	A	67044773	A	A	67044773	2	1	175	1	0	0	0	0	0	0	0	1	343	991	35	4		4	ADRBK1	11	67044773	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08	17041184	67044773	67961743	77	32791											
DLG2	1740	broad.mit.edu	37	chr11	83641505	83641505	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcacatagtttgttcacagtGctgtaaacaggttccggagg	10	12	11	8	1	2	0	2	0	0	0	3	1	3	1	1	3	2	5	1	3	3	5			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr11:83641505G>T	uc001paj.2	-	10	1350	c.1047C>A	c.(1045-1047)AGC>AGA	p.S349R	DLG2_uc001pai.2_Intron|DLG2_uc010rsy.1_Missense_Mutation_p.S316R|DLG2_uc010rsz.1_Missense_Mutation_p.S349R|DLG2_uc010rta.1_Missense_Mutation_p.S349R|DLG2_uc001pak.2_Missense_Mutation_p.S454R|DLG2_uc010rtb.1_Missense_Mutation_p.S316R|DLG2_uc001pal.1_Missense_Mutation_p.S349R|DLG2_uc001pam.1_Missense_Mutation_p.S388R	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	349						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TGTTCACAGTGCTGTAAACAG	0.483													20	8					1.2644e-06	1.35313e-06	1	0	T	83641505	T	T	83641505	3	4	175	1	0	0	0	0	1	0	0	0	4577	1310	46	4	1671	4	DLG2	11	83641505	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	16596732	83641505	51365011	78	32792											
MTNR1B	4544	broad.mit.edu	37	chr11	92714995	92714995	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagcacccagtacacggcGgcagtggtggtcatccactt	8	7	12	14	2	1	0	1	0	0	0	2	0	2	0	3	4	2	3	3	4	1	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr11:92714995G>A	uc001pdk.1	+	2	709	c.606G>A	c.(604-606)GCG>GCA	p.A202A		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	202	Helical; Name=5; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	AGTACACGGCGGCAGTGGTGG	0.607													21	7					0	0	0	0	A	92714995	A	A	92714995	2	1	175	1	0	0	0	0	0	0	0	1	10005	1103	39	1		1	MTNR1B	11	92714995	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08	9073490	92714995	42291521	79	32793											
PRDM10	56980	broad.mit.edu	37	chr11	129794994	129794994	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagatcacaggtcagtgggCagttcccctcccgcccatgg	8	7	12	14	1	2	1	2	0	0	1	4	2	4	1	4	3	0	2	4	3	0	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr11:129794994C>A	uc001qfm.2	-	13	1905	c.1673G>T	c.(1672-1674)TGC>TTC	p.C558F	PRDM10_uc001qfj.2_Missense_Mutation_p.C472F|PRDM10_uc001qfk.2_Missense_Mutation_p.C468F|PRDM10_uc001qfl.2_Missense_Mutation_p.C472F|PRDM10_uc010sbx.1_Missense_Mutation_p.C468F|PRDM10_uc001qfn.2_Missense_Mutation_p.C554F	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		GGTCAGTGGGCAGTTCCCCTC	0.527													40	25					3.09479e-21	3.56192e-21	1	0	A	129794994	A	A	129794994	3	1	175	1	0	0	0	0	1	0	0	0	12513	710	25	4	1849	4	PRDM10	11	129794994	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	37079999	129794994	5211522	80	32794											
CHD4	1108	broad.mit.edu	37	chr12	6691342	6691342	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ataacaccaattctagtaagGacatgctggcgagacaggcc	14	7	10	10	1	1	1	0	0	1	1	1	3	1	2	2	3	2	2	2	3	4	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr12:6691342G>C	uc001qpo.2	-	30	4640	c.4476C>G	c.(4474-4476)GTC>GTG	p.V1492V	CHD4_uc001qpn.2_Silent_p.V1485V|CHD4_uc001qpp.2_Silent_p.V1517V|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1492					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TTCTAGTAAGGACATGCTGGC	0.453													8	55					0	0	0	0	C	6691342	C	C	6691342	2	2	175	1	0	0	0	0	0	0	0	1	3342	1161	41	2		2	CHD4	12	6691342	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08		6691342	127160553	81	32795											
RERG	85004	broad.mit.edu	37	chr12	15262053	15262053	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgggctgcctaactactGattttggtgagcatcttgtt	7	15	11	8	0	1	2	0	2	1	0	1	2	1	2	1	2	5	4	1	2	2	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr12:15262053G>A	uc001rcs.2	-	4	731	c.591C>T	c.(589-591)ATC>ATT	p.I197I	RERG_uc001rct.2_Silent_p.I197I|RERG_uc010shu.1_Silent_p.I178I	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	197					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						CCTAACTACTGATTTTGGTGA	0.493													16	220					0	0	0	0	A	15262053	A	A	15262053	2	1	175	1	0	0	0	0	0	0	0	1	13297	1280	45	2		2	RERG	12	15262053	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08	8570711	15262053	118589842	82	32796											
PAN2	9924	broad.mit.edu	37	chr12	56721836	56721836	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgtctcatgatggtgacTccaggcgtctctactgcata	7	13	10	11	1	3	2	1	2	3	0	6	2	4	2	1	2	2	1	1	2	2	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr12:56721836T>A	uc001skx.2	-	5	967	c.594A>T	c.(592-594)GGA>GGT	p.G198G	PAN2_uc001skz.2_Silent_p.G198G|PAN2_uc001sky.2_Silent_p.G198G	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	198					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TGATGGTGACTCCAGGCGTCT	0.517													12	19					0	0	0	0	A	56721836	A	A	56721836	2	1	175	1	0	0	0	0	0	0	0	1	11468	1538	54	5		5	PAN2	12	56721836	Silent	SNP	T	TCGA-CV-5440-01A-01D-1512-08	41459783	56721836	77130059	83	32797											
NAV3	89795	broad.mit.edu	37	chr12	78562566	78562566	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatagaactaagagaaaccaTtgaaatgctgaaggctcaga	18	8	9	6	0	1	5	1	2	0	3	1	6	1	5	1	1	3	2	1	1	7	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr12:78562566T>C	uc001syp.2	+	24	5074	c.4901T>C	c.(4900-4902)ATT>ACT	p.I1634T	NAV3_uc001syo.2_Missense_Mutation_p.I1634T|NAV3_uc010sub.1_Missense_Mutation_p.I1120T|NAV3_uc009zsf.2_Missense_Mutation_p.I465T	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1634	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGAGAAACCATTGAAATGCTG	0.413										HNSCC(70;0.22)			7	41					0	0	0	0	C	78562566	C	C	78562566	3	2	175	1	0	0	0	0	1	0	0	0	10238	1493	52	5	4995	5	NAV3	12	78562566	Missense_Mutation	SNP	T	TCGA-CV-5440-01A-01D-1512-08	21840730	78562566	55289329	84	32798											
ACSS3	79611	broad.mit.edu	37	chr12	81503433	81503433	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgctatcatctatgacagtCctgttacaaacactaaagca	14	12	5	10	0	2	1	1	1	1	0	3	1	3	1	1	0	4	3	1	0	6	5			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr12:81503433C>T	uc001szl.1	+	2	497	c.406C>T	c.(406-408)CCT>TCT	p.P136S	ACSS3_uc001szm.1_Missense_Mutation_p.P135S	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	136						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CTATGACAGTCCTGTTACAAA	0.318													7	24					0	0	0	0	T	81503433	T	T	81503433	3	4	175	1	0	0	0	0	1	0	0	0	190	855	30	2	412	2	ACSS3	12	81503433	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	2940867	81503433	52348462	85	32799											
PPFIA2	8499	broad.mit.edu	37	chr12	81762520	81762520	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccttttcttctagagcaGccattctttcctttaagtgt	7	19	5	10	0	3	1	0	0	3	1	4	1	4	1	3	0	3	1	3	0	3	9			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr12:81762520G>C	uc001szo.1	-	13	1627	c.1466C>G	c.(1465-1467)GCT>GGT	p.A489G	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	415										ovary(3)|lung(2)|pancreas(1)	6						TTCTAGAGCAGCCATTCTTTC	0.353													12	70					0	0	0	0	C	81762520	C	C	81762520	3	2	175	1	0	0	0	0	1	0	0	0	12365	971	34	4	2387	4	PPFIA2	12	81762520	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	259087	81762520	52089375	86	32800											
RNF17	56163	broad.mit.edu	37	chr13	25451309	25451309	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcttcaaggaaaacaactCtatgctgtgtccatggtaag	12	12	9	8	0	3	0	1	0	2	0	4	1	4	1	1	2	3	2	1	2	6	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr13:25451309C>G	uc001upr.2	+	34	4799	c.4758C>G	c.(4756-4758)CTC>CTG	p.L1586L	RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Silent_p.L1582L|RNF17_uc001ups.2_Silent_p.L1525L|RNF17_uc010aac.2_Silent_p.L778L|RNF17_uc010aad.2_Silent_p.L596L	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1586					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GAAAACAACTCTATGCTGTGT	0.418													7	11					0	0	0	0	G	25451309	G	G	25451309	2	3	175	1	0	0	0	0	0	0	0	1	13526	900	32	2		2	RNF17	13	25451309	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08		25451309	89718569	87	32801											
BRCA2	675	broad.mit.edu	37	chr13	32914805	32914805	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctagacaaaatgtatcaaaaAtacttcctcgtgttgataag	16	12	6	7	1	1	2	1	1	0	1	3	2	2	2	1	0	1	2	1	0	8	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr13:32914805A>G	uc001uub.1	+	11	6540	c.6313A>G	c.(6313-6315)ATA>GTA	p.I2105V		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2105					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TGTATCAAAAATACTTCCTCG	0.328			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			13	15					0	0	0	0	G	32914805	G	G	32914805	3	3	175	1	0	0	0	0	1	0	0	0	1504	101	4	5	6351	5	BRCA2	13	32914805	Missense_Mutation	SNP	A	TCGA-CV-5440-01A-01D-1512-08	7463496	32914805	82255073	88	32802											
FNDC3A	22862	broad.mit.edu	37	chr13	49752754	49752754	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagatcttgcttacacagtGaaaaatctcagacgtagtac	15	10	8	8	1	2	3	1	1	2	2	3	4	2	3	0	0	3	3	0	0	6	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr13:49752754G>A	uc001vcm.2	+	14	1886	c.1581G>A	c.(1579-1581)GTG>GTA	p.V527V	FNDC3A_uc001vcn.2_Silent_p.V527V|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Silent_p.V453V|FNDC3A_uc001vcq.2_Silent_p.V471V	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	527	Fibronectin type-III 3.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		CTTACACAGTGAAAAATCTCA	0.343													5	34					0	0	0	0	A	49752754	A	A	49752754	2	1	175	1	0	0	0	0	0	0	0	1	6001	1277	45	2		2	FNDC3A	13	49752754	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08	16837949	49752754	65417124	89	32803											
ATP11A	23250	broad.mit.edu	37	chr13	113439477	113439477	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaagagaattgggtggacaGcaggaccatctacgtgggac	13	6	15	7	1	1	2	0	0	1	2	1	6	1	5	1	4	2	1	1	4	3	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr13:113439477G>T	uc001vsi.3	+	2	156	c.68G>T	c.(67-69)AGC>ATC	p.S23I	ATP11A_uc001vsj.3_Missense_Mutation_p.S23I|ATP11A_uc001vsm.1_5'UTR	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	23	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TGGGTGGACAGCAGGACCATC	0.572											OREG0003855	type=REGULATORY REGION|Gene=ATP11A|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	47	37					4.44401e-20	5.08284e-20	1	0	T	113439477	T	T	113439477	3	4	175	1	0	0	0	0	1	0	0	0	1121	971	34	4	74	4	ATP11A	13	113439477	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	63686723	113439477	1730401	90	32804											
PTPN21	11099	broad.mit.edu	37	chr14	88945294	88945294	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggagcccttccacgatgttCttcttcccagagagaaggtc	8	10	11	12	1	2	2	0	0	2	2	5	5	4	3	3	2	1	1	3	2	1	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr14:88945294C>T	uc001xwv.3	-	13	2812	c.2481G>A	c.(2479-2481)AAG>AAA	p.K827K	PTPN21_uc010twc.1_Silent_p.K623K	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	827						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						CCACGATGTTCTTCTTCCCAG	0.647													35	51					0	0	0	0	T	88945294	T	T	88945294	2	4	175	1	0	0	0	0	0	0	0	1	12851	912	32	2		2	PTPN21	14	88945294	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08		88945294	18404246	91	32805											
ATXN3	4287	broad.mit.edu	37	chr14	92563179	92563179	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagcacaaagtgagccttCttgctaatatttccaaaaga	14	12	7	8	0	1	3	0	2	1	1	2	3	2	3	2	0	3	2	2	0	5	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr14:92563179C>A	uc001yac.3	-	2	97	c.28G>T	c.(28-30)GAA>TAA	p.E10*	ATXN3_uc010aug.2_Nonsense_Mutation_p.E10*|ATXN3_uc001yad.3_Intron|ATXN3_uc010auh.2_Nonsense_Mutation_p.E10*|ATXN3_uc001yae.3_5'UTR|ATXN3_uc010twl.1_Intron	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	10	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		AGTGAGCCTTCTTGCTAATAT	0.299													16	43					7.07596e-05	7.39943e-05	1	0	A	92563179	A	A	92563179	4	1	175	1	0	0	0	0	0	1	0	0	1215	922	32	2	1097	2	ATXN3	14	92563179	Nonsense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	3617885	92563179	14786361	92	32806											
YY1	7528	broad.mit.edu	37	chr14	100706146	100706146	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaagagttacctcagcggcGgggccggcgcggcgggcggc	6	3	20	12	7	1	2	1	0	0	2	1	2	1	2	2	7	2	1	2	7	2	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr14:100706146G>A	uc001ygy.1	+	1	1045	c.565G>A	c.(565-567)GGG>AGG	p.G189R		NM_003403	NP_003394	P25490	TYY1_HUMAN	YY1 transcription factor	189					cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding				0		Melanoma(154;0.152)				cctcagcggcggggccggcgc	0.204													5	12					0	0	0	0	A	100706146	A	A	100706146	3	1	175	1	0	0	0	0	1	0	0	0	17575	1116	39	1	567	1	YY1	14	100706146	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	8142967	100706146	6643394	93	32807											
CDAN1	146059	broad.mit.edu	37	chr15	43026218	43026218	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggctgaaaggagacagcttGagtagagggaggcatcacca	13	6	15	7	0	1	4	1	2	0	2	1	6	1	5	1	4	1	4	1	4	2	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr15:43026218G>C	uc001zql.2	-	8	1402	c.1285C>G	c.(1285-1287)CAA>GAA	p.Q429E	CDAN1_uc001zqk.2_5'UTR|CDAN1_uc010bcx.1_RNA	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	429						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		GAGACAGCTTGAGTAGAGGGA	0.468													16	8					0	0	0	0	C	43026218	C	C	43026218	3	2	175	1	0	0	0	0	1	0	0	0	3069	1299	45	2	2482	2	CDAN1	15	43026218	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08		43026218	59505174	94	32808											
CATSPER2	117155	broad.mit.edu	37	chr15	43939313	43939313	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgatgaagtttttgaagagaGgacctgttgtctcttaagga	11	14	12	4	0	1	4	0	3	1	1	2	7	1	6	1	2	0	2	1	2	3	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr15:43939313G>A	uc001zsh.2	-	4	538	c.323C>T	c.(322-324)CCT>CTT	p.P108L	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Missense_Mutation_p.P108L|CATSPER2_uc001zsj.2_Missense_Mutation_p.P108L|CATSPER2_uc001zsk.2_Missense_Mutation_p.P108L	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	108	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TTTGAAGAGAGGACCTGTTGT	0.358													29	25					0	0	0	0	A	43939313	A	A	43939313	3	1	175	1	0	0	0	0	1	0	0	0	2700	1000	35	4	1348	4	CATSPER2	15	43939313	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	913095	43939313	58592079	95	32809											
SPG11	80208	broad.mit.edu	37	chr15	44887540	44887540	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagatgactgaaagatcctCaaggttccaggtatggtcct	11	10	10	10	0	1	4	1	2	0	2	4	4	4	4	4	3	0	2	4	3	3	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr15:44887540C>T	uc001ztx.2	-	26	4583	c.4552G>A	c.(4552-4554)GAG>AAG	p.E1518K	SPG11_uc010ueh.1_Missense_Mutation_p.E1518K|SPG11_uc010uei.1_Missense_Mutation_p.E1518K|SPG11_uc001zty.1_Missense_Mutation_p.E247K	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1518	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		GAAAGATCCTCAAGGTTCCAG	0.418													28	25					0	0	0	0	T	44887540	T	T	44887540	3	4	175	1	0	0	0	0	1	0	0	0	15107	835	29	2	2839	2	SPG11	15	44887540	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	948227	44887540	57643852	96	32810											
SECISBP2L	9728	broad.mit.edu	37	chr15	49320740	49320740	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtaaccactatcactgtcAatgtcggcttcactagcccc	10	10	6	15	1	3	0	3	0	0	0	4	0	3	0	3	1	2	2	3	1	4	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr15:49320740A>G	uc001zxe.1	-	5	938	c.804T>C	c.(802-804)ATT>ATC	p.I268I	SECISBP2L_uc001zxd.1_Silent_p.I268I|SECISBP2L_uc010bep.1_Silent_p.I30I|SECISBP2L_uc010beq.1_Intron	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	268										breast(1)|skin(1)	2						TATCACTGTCAATGTCGGCTT	0.512													14	12					0	0	0	0	G	49320740	G	G	49320740	2	3	175	1	0	0	0	0	0	0	0	1	14072	126	5	5		5	SECISBP2L	15	49320740	Silent	SNP	A	TCGA-CV-5440-01A-01D-1512-08	4433200	49320740	53210652	97	32811											
ZNF592	9640	broad.mit.edu	37	chr15	85326988	85326988	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacagcagcagcaaaggctCaccgtctgtggctgccagct	9	7	12	13	1	2	1	1	1	1	0	2	1	2	1	2	2	5	6	2	2	1	0			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr15:85326988C>T	uc002bld.2	+	4	1418	c.1082C>T	c.(1081-1083)TCA>TTA	p.S361L	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	361					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCAAAGGCTCACCGTCTGTG	0.527													18	40					0	0	0	0	T	85326988	T	T	85326988	3	4	175	1	0	0	0	0	1	0	0	0	18089	838	29	2	1084	2	ZNF592	15	85326988	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	36006248	85326988	17204404	98	32812											
ALPK3	57538	broad.mit.edu	37	chr15	85405871	85405871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgttccccttcagttggaGaagagattgagatgacccct	9	11	10	11	0	1	4	1	2	0	3	2	7	2	4	5	1	0	2	5	1	1	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr15:85405871G>A	uc002ble.2	+	10	4908	c.4741G>A	c.(4741-4743)GAA>AAA	p.E1581K	ALPK3_uc010upc.1_5'Flank	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1581					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TTCAGTTGGAGAAGAGATTGA	0.572													16	30					0	0	0	0	A	85405871	A	A	85405871	3	1	175	1	0	0	0	0	1	0	0	0	546	943	33	2	4779	2	ALPK3	15	85405871	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	78883	85405871	17125521	99	32813											
ALPK3	57538	broad.mit.edu	37	chr15	85405916	85405916	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtttgctaagggtctggctGactctggctgctggggggac	4	12	17	8	0	2	1	0	1	2	0	2	2	2	2	0	6	2	5	0	6	1	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr15:85405916G>A	uc002ble.2	+	10	4953	c.4786G>A	c.(4786-4788)GAC>AAC	p.D1596N	ALPK3_uc010upc.1_5'Flank	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1596	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGGTCTGGCTGACTCTGGCTG	0.582													13	33					0	0	0	0	A	85405916	A	A	85405916	3	1	175	1	0	0	0	0	1	0	0	0	546	1290	45	2	4824	2	ALPK3	15	85405916	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	45	85405916	17125476	100	32814											
C15orf58	390637	broad.mit.edu	37	chr15	90785083	90785083	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggtccgagtaattctgtggGcccggaagtccagctttggg	6	10	16	9	2	1	0	0	0	1	0	3	2	3	1	3	4	1	2	3	4	2	3	rs35018599		TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr15:90785083G>C	uc002bpc.2	+	4	1122	c.943G>C	c.(943-945)GCC>CCC	p.A315P		NM_001013657	NP_001013679	Q6ZNW5	VTC2_HUMAN	hypothetical protein LOC390637	315					glucose metabolic process	cytoplasm	GDP-D-glucose phosphorylase activity				0						AATTCTGTGGGCCCGGAAGTC	0.552													27	32					0	0	0	0	C	90785083	C	C	90785083	3	2	175	1	0	0	0	0	1	0	0	0	1812	1203	42	4	945	4	C15orf58	15	90785083	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	5379167	90785083	11746309	101	32815											
PKD1	5310	broad.mit.edu	37	chr16	2164258	2164258	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgccgtcacccgcaggctGaggttggcccggctggcgct	3	7	15	16	5	1	1	1	1	0	0	2	1	2	1	4	5	0	5	4	5	0	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr16:2164258G>C	uc002cos.1	-	11	2975	c.2766C>G	c.(2764-2766)CTC>CTG	p.L922L	PKD1_uc002cot.1_Silent_p.L922L	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	922	Extracellular (Potential).|PKD 3.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCCGCAGGCTGAGGTTGGCCC	0.672													7	18					0	0	0	0	C	2164258	C	C	2164258	2	2	175	1	0	0	0	0	0	0	0	1	12018	1277	45	2		2	PKD1	16	2164258	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08		2164258	88190495	102	32816											
PKD1	5310	broad.mit.edu	37	chr16	2166979	2166979	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctggcagctctccaggctGaaggcctcgccctgcggcgc	4	8	13	16	3	2	1	0	1	2	0	4	1	2	1	3	4	2	3	3	4	1	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr16:2166979G>A	uc002cos.1	-	7	1670	c.1461C>T	c.(1459-1461)TTC>TTT	p.F487F	PKD1_uc002cot.1_Silent_p.F487F	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	487	C-type lectin.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TCTCCAGGCTGAAGGCCTCGC	0.711													3	5					0	0	0	0	A	2166979	A	A	2166979	2	1	175	1	0	0	0	0	0	0	0	1	12018	1281	45	2		2	PKD1	16	2166979	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08	2721	2166979	88187774	103	32817											
MKL2	57496	broad.mit.edu	37	chr16	14312825	14312825	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaagttagtgaatcgccAtctcctgtgactacaaacac	14	9	6	12	1	1	2	0	2	1	0	3	2	1	2	3	0	2	1	3	0	6	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr16:14312825A>G	uc010uza.1	+	8	818	c.663A>G	c.(661-663)CCA>CCG	p.P221P	MKL2_uc002dcg.2_Silent_p.P221P|MKL2_uc002dch.2_Silent_p.P210P|MKL2_uc010uzb.1_Silent_p.P170P	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	210					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						GTGAATCGCCATCTCCTGTGA	0.458													8	28					0	0	0	0	G	14312825	G	G	14312825	2	3	175	1	0	0	0	0	0	0	0	1	9655	204	8	5		5	MKL2	16	14312825	Silent	SNP	A	TCGA-CV-5440-01A-01D-1512-08	12145846	14312825	76041928	104	32818											
PSMB10	5699	broad.mit.edu	37	chr16	67969351	67969351	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcggctggaaccggtcttctAgcaccgccagggccgcgtcc	5	7	13	16	5	2	0	0	0	2	0	4	1	3	1	5	4	2	2	5	4	2	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr16:67969351A>G	uc002eux.1	-	6	631	c.530T>C	c.(529-531)CTA>CCA	p.L177P		NM_002801	NP_002792	P40306	PSB10_HUMAN	proteasome beta 10 subunit proprotein	177					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|humoral immune response|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		CCGGTCTTCTAGCACCGCCAG	0.647													12	37					0	0	0	0	G	67969351	G	G	67969351	3	3	175	1	0	0	0	0	1	0	0	0	12737	420	15	5	303	5	PSMB10	16	67969351	Missense_Mutation	SNP	A	TCGA-CV-5440-01A-01D-1512-08	53656526	67969351	22385402	105	32819											
PLCG2	5336	broad.mit.edu	37	chr16	81971422	81971422	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgggcgcacgggctacgttCtgcagcctgagagcatgagg	8	7	16	10	3	1	2	0	2	1	1	1	3	1	2	1	3	4	5	1	3	1	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr16:81971422C>T	uc002fgt.2	+	28	3264	c.3112C>T	c.(3112-3114)CTG>TTG	p.L1038L		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	1038	PI-PLC Y-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						GGGCTACGTTCTGCAGCCTGA	0.522													23	21					0	0	0	0	T	81971422	T	T	81971422	2	4	175	1	0	0	0	0	0	0	0	1	12091	912	32	2		2	PLCG2	16	81971422	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08	14002071	81971422	8383331	106	32820											
ANKRD11	29123	broad.mit.edu	37	chr16	89350644	89350644	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attttgagggccggtcttttGatttcttctttctctcctct	3	21	7	10	1	5	2	0	2	5	0	7	2	6	2	2	2	0	0	2	2	0	7			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr16:89350644G>C	uc002fmx.1	-	9	2767	c.2306C>G	c.(2305-2307)TCA>TGA	p.S769*	ANKRD11_uc002fmy.1_Nonsense_Mutation_p.S769*|ANKRD11_uc002fnc.1_Nonsense_Mutation_p.S769*|ANKRD11_uc002fnb.1_Nonsense_Mutation_p.S726*	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	769	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCGGTCTTTTGATTTCTTCTT	0.348													6	30					0	0	0	0	C	89350644	C	C	89350644	4	2	175	1	0	0	0	0	0	1	0	0	639	1294	45	2	5705	2	ANKRD11	16	89350644	Nonsense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	7379222	89350644	1004109	107	32821											
CD68	968	broad.mit.edu	37	chr17	7483025	7483025	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgtgcttttctcgggggcCctgctggggctactggcagg	2	11	17	11	1	1	0	0	0	1	0	2	0	1	0	1	6	3	5	1	6	1	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr17:7483025C>T	uc002ghv.2	+	1	221	c.30C>T	c.(28-30)GCC>GCT	p.A10A	CD68_uc002ghu.2_Silent_p.A10A	NM_001251	NP_001242	P34810	CD68_HUMAN	CD68 antigen isoform A	10						endosome membrane|integral to membrane|lysosomal membrane|membrane fraction|plasma membrane					0						TCTCGGGGGCCCTGCTGGGGC	0.637													3	11					0	0	0	0	T	7483025	T	T	7483025	2	4	175	1	0	0	0	0	0	0	0	1	3045	610	22	4		4	CD68	17	7483025	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08		7483025	73712185	108	32822											
TP53	7157	broad.mit.edu	37	chr17	7578403	7578403	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagcgctcatggtgggggCagcgcctcacaacctccgtc	7	6	13	15	3	2	0	2	0	0	0	4	0	3	0	3	3	4	3	3	3	1	0			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr17:7578403C>T	uc002gim.2	-	5	721	c.527G>A	c.(526-528)TGC>TAC	p.C176Y	TP53_uc002gig.1_Missense_Mutation_p.C176Y|TP53_uc002gih.2_Missense_Mutation_p.C176Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C44Y|TP53_uc010cng.1_Missense_Mutation_p.C44Y|TP53_uc002gii.1_Missense_Mutation_p.C44Y|TP53_uc010cnh.1_Missense_Mutation_p.C176Y|TP53_uc010cni.1_Missense_Mutation_p.C176Y|TP53_uc002gij.2_Missense_Mutation_p.C176Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C83Y|TP53_uc002gio.2_Missense_Mutation_p.C44Y|TP53_uc010vug.1_Missense_Mutation_p.C137Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	176	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	CP -> FS (in a sporadic cancer; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C176F(102)|p.C176Y(56)|p.C176S(19)|p.C176W(11)|p.C176R(8)|p.C176fs*71(7)|p.0?(7)|p.C176*(6)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.C176G(3)|p.C176fs*5(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.C44Y(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R42fs*24(1)|p.C83Y(1)|p.C176fs*72(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.C176del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.C176fs*6(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGTGGGGGCAGCGCCTCAC	0.652		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	40					0	0	0	0	T	7578403	T	T	7578403	3	4	175	1	0	0	0	0	1	0	0	0	16448	710	25	4	771	4	TP53	17	7578403	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	95378	7578403	73616807	109	32823											
TP53	7157	broad.mit.edu	37	chr17	7579358	7579358	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaatgcaagaagcccagaCggaaaccgtagctgccctgg	13	4	12	12	2	0	3	0	0	0	3	0	4	0	4	3	2	5	3	3	2	5	1	rs11540654		TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr17:7579358C>A	uc002gim.2	-	4	523	c.329G>T	c.(328-330)CGT>CTT	p.R110L	TP53_uc002gig.1_Missense_Mutation_p.R110L|TP53_uc002gih.2_Missense_Mutation_p.R110L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.R110L|TP53_uc010cni.1_Missense_Mutation_p.R110L|TP53_uc002gij.2_Missense_Mutation_p.R110L|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.R71L|TP53_uc010cnk.1_Missense_Mutation_p.R125L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	110	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		R -> G (in a sporadic cancer; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> H (in sporadic cancers; somatic mutation).|R -> L (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R110L(24)|p.R110P(8)|p.0?(7)|p.R110fs*13(5)|p.R110C(4)|p.G59fs*23(3)|p.F109_R110delFR(2)|p.R110H(2)|p.V73fs*9(1)|p.F109_R110insXX(1)|p.G105_T125del21(1)|p.R110fs*18(1)|p.Y107fs*44(1)|p.R110fs*39(1)|p.Y103_G112>C(1)|p.R110S(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y107fs*38(1)|p.Y103_L111>L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAGCCCAGACGGAAACCGTA	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	44					1.56738e-10	1.74559e-10	1	0	A	7579358	A	A	7579358	3	1	175	1	0	0	0	0	1	0	0	0	16448	536	19	3	973	3	TP53	17	7579358	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	955	7579358	73615852	110	32824											
GLP2R	9340	broad.mit.edu	37	chr17	9774114	9774114	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcttctcatttctaagctCaaagctcatcaaatgtgctt	12	14	5	10	0	5	0	4	0	2	0	6	0	5	0	0	0	4	4	0	0	4	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr17:9774114C>G	uc002gmd.1	+	10	1107	c.1107C>G	c.(1105-1107)CTC>CTG	p.L369L		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	369	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	TTTCTAAGCTCAAAGCTCATC	0.398													39	74					0	0	0	0	G	9774114	G	G	9774114	2	3	175	1	0	0	0	0	0	0	0	1	6490	813	29	2		2	GLP2R	17	9774114	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08	2194756	9774114	71421096	111	32825											
MYH3	4621	broad.mit.edu	37	chr17	10544406	10544406	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgtttattacacacctttGtttaaaatcgccatagagaa	14	14	5	8	1	0	1	0	0	0	1	1	2	0	1	2	0	1	2	2	0	6	7			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr17:10544406G>C	uc002gmq.1	-	18	2238	c.2161C>G	c.(2161-2163)CAA>GAA	p.Q721E		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	721	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						ACACACCTTTGTTTAAAATCG	0.453													13	90					0	0	0	0	C	10544406	C	C	10544406	3	2	175	1	0	0	0	0	1	0	0	0	10089	1386	48	4	3753	4	MYH3	17	10544406	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	770292	10544406	70650804	112	32826											
GGNBP2	79893	broad.mit.edu	37	chr17	34935812	34935812	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagacatggcagatgctttTctatcttggtgttgatgctt	7	16	11	7	0	2	3	0	1	2	2	2	3	2	3	0	2	2	5	0	2	1	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr17:34935812T>C	uc002hnb.2	+	8	1232	c.983T>C	c.(982-984)TTC>TCC	p.F328S	GGNBP2_uc002hna.2_Missense_Mutation_p.F328S|GGNBP2_uc002hnc.1_Missense_Mutation_p.F157S	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	328					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		CAGATGCTTTTCTATCTTGGT	0.433													26	95					0	0	0	0	C	34935812	C	C	34935812	3	2	175	1	0	0	0	0	1	0	0	0	6396	1783	62	5	1009	5	GGNBP2	17	34935812	Missense_Mutation	SNP	T	TCGA-CV-5440-01A-01D-1512-08	24391406	34935812	46259398	113	32827											
HOXB7	3217	broad.mit.edu	37	chr17	46685394	46685394	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtagcgattgtagtgaaatTctttctccagctccagggtc	8	13	11	9	1	2	1	0	1	2	0	5	2	3	1	2	2	2	3	2	2	3	5			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr17:46685394T>C	uc002inv.2	-	2	567	c.464A>G	c.(463-465)GAA>GGA	p.E155G		NM_004502	NP_004493	P09629	HXB7_HUMAN	homeobox B7	155	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTAGTGAAATTCTTTCTCCAG	0.547													42	54					0	0	0	0	C	46685394	C	C	46685394	3	2	175	1	0	0	0	0	1	0	0	0	7345	1783	62	5	193	5	HOXB7	17	46685394	Missense_Mutation	SNP	T	TCGA-CV-5440-01A-01D-1512-08	11749582	46685394	34509816	114	32828											
C17orf28	283987	broad.mit.edu	37	chr17	72951930	72951930	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttgttgaagacctccaggagGaagaagaccaggtggtggtt	11	9	15	6	0	0	4	0	1	0	3	1	6	1	6	3	5	0	2	3	5	3	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr17:72951930G>A	uc002jmj.3	-	13	1742	c.1593C>T	c.(1591-1593)TTC>TTT	p.F531F	C17orf28_uc002jmi.2_5'Flank|C17orf28_uc010wrs.1_Silent_p.F330F	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	531						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					CCTCCAGGAGGAAGAAGACCA	0.587													27	34					0	0	0	0	A	72951930	A	A	72951930	2	1	175	1	0	0	0	0	0	0	0	1	1860	1165	41	2		2	C17orf28	17	72951930	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08	26266536	72951930	8243280	115	32829											
RNF213	57674	broad.mit.edu	37	chr17	78343325	78343325	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccattgaaaagcatgcccGcttccggcagatgtgcaaca	12	7	10	12	2	0	2	0	1	0	1	1	2	1	2	3	1	5	4	3	1	3	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr17:78343325G>A	uc002jyh.1	+	20	6621	c.6398G>A	c.(6397-6399)CGC>CAC	p.R2133H	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.R515H	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AAGCATGCCCGCTTCCGGCAG	0.498													4	102					0	0	0	0	A	78343325	A	A	78343325	3	1	175	1	0	0	0	0	1	0	0	0	13542	1087	38	1	12672	1	RNF213	17	78343325	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	5391395	78343325	2851885	116	32830											
LAMA3	3909	broad.mit.edu	37	chr18	21526172	21526172	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggactgagggcccgggaggGaagtttgcctggaaactcca	9	7	16	9	1	0	1	0	1	0	0	1	5	1	5	3	5	2	1	3	5	2	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr18:21526172G>A	uc002kuq.2	+	70	9361	c.9275G>A	c.(9274-9276)GGA>GAA	p.G3092E	LAMA3_uc002kur.2_Missense_Mutation_p.G3036E|LAMA3_uc002kus.3_Missense_Mutation_p.G1483E|LAMA3_uc002kut.3_Missense_Mutation_p.G1427E	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	3092	Laminin G-like 4.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCCCGGGAGGGAAGTTTGCCT	0.493													7	44					0	0	0	0	A	21526172	A	A	21526172	3	1	175	1	0	0	0	0	1	0	0	0	8647	1174	41	2	9728	2	LAMA3	18	21526172	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08		21526172	56551076	117	32831											
XAB2	56949	broad.mit.edu	37	chr19	7685323	7685323	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccacgtctgccagaacgCgccggtcgtctgcgtggggg	4	8	15	14	6	2	1	0	0	2	1	4	1	3	1	3	3	3	0	3	3	1	1	rs4134865		TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr19:7685323C>T	uc002mgx.2	-	16	2130	c.2104G>A	c.(2104-2106)GCG>ACG	p.A702T		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	702	HAT 14.				transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						TGCCAGAACGCGCCGGTCGTC	0.657								Direct_reversal_of_damage|NER					10	73					0	0	0	0	T	7685323	T	T	7685323	3	4	175	1	0	0	0	0	1	0	0	0	17486	768	27	1	479	1	XAB2	19	7685323	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08		7685323	51443660	118	32832											
RAB3A	5864	broad.mit.edu	37	chr19	18313497	18313497	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcttgaacatgtagtcgaaGttctgatccgaggactcctt	10	13	9	9	2	2	2	0	2	2	0	5	5	4	3	2	1	1	2	2	1	3	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr19:18313497G>C	uc002nie.2	-	2	223	c.54C>G	c.(52-54)AAC>AAG	p.N18K		NM_002866	NP_002857	P20336	RAB3A_HUMAN	RAB3A, member RAS oncogene family	18					glutamate secretion|protein transport|small GTPase mediated signal transduction	clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|plasma membrane|synaptic vesicle	GTP binding|GTPase activity				0						TGTAGTCGAAGTTCTGATCCG	0.582											OREG0025360	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	99					0	0	0	0	C	18313497	C	C	18313497	3	2	175	1	0	0	0	0	1	0	0	0	12996	1020	36	4	624	4	RAB3A	19	18313497	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	10628174	18313497	40815486	119	32833											
CRTC1	23373	broad.mit.edu	37	chr19	18853806	18853806	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcccaacgtgaaccagatCgggagtggcaccatggacct	10	6	12	13	2	0	2	0	1	0	1	1	4	0	4	4	3	3	1	4	3	2	0			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr19:18853806C>T	uc002nkb.3	+	2	301	c.213C>T	c.(211-213)ATC>ATT	p.I71I	CRTC1_uc010ebv.2_Silent_p.I71I	NM_015321	NP_056136	Q6UUV9	CRTC1_HUMAN	mucoepidermoid carcinoma translocated 1 isoform	71					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	salivary_gland(474)|lung(35)|thyroid(4)|breast(3)|skin(2)|ovary(1)	519						TGAACCAGATCGGGAGTGGCA	0.667													17	25					0	0	0	0	T	18853806	T	T	18853806	2	4	175	1	0	0	0	0	0	0	0	1	3914	874	31	1		1	CRTC1	19	18853806	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08	540309	18853806	40275177	120	32834											
ZNF43	7594	broad.mit.edu	37	chr19	21991574	21991574	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cacatttgtagggtttctctCcagtatgagttaacttatgt	9	17	8	7	0	1	1	0	1	1	0	3	1	2	1	1	1	1	4	1	1	4	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr19:21991574C>G	uc002nqj.2	-	4	1395	c.1265G>C	c.(1264-1266)GGA>GCA	p.G422A	ZNF43_uc010ecv.2_Missense_Mutation_p.G416A|ZNF43_uc002nql.2_Missense_Mutation_p.G416A|ZNF43_uc002nqm.2_Missense_Mutation_p.G416A|ZNF43_uc002nqk.2_Missense_Mutation_p.G352A	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		GGGTTTCTCTCCAGTATGAGT	0.373													7	44					0	0	0	0	G	21991574	G	G	21991574	3	3	175	1	0	0	0	0	1	0	0	0	17970	855	30	2	1168	2	ZNF43	19	21991574	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	3137768	21991574	37137409	121	32835											
ZNF227	7770	broad.mit.edu	37	chr19	44738977	44738977	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaattaaccaggtgtcttCaggggaagagttcccagtta	11	11	12	7	0	2	2	1	1	1	1	3	3	3	3	2	3	1	2	2	3	4	4			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr19:44738977C>T	uc002oyu.2	+	6	599	c.394C>T	c.(394-396)CAG>TAG	p.Q132*	ZNF227_uc010xwu.1_Nonsense_Mutation_p.Q81*|ZNF227_uc002oyv.2_Nonsense_Mutation_p.Q132*|ZNF227_uc010xwv.1_Nonsense_Mutation_p.Q81*|ZNF227_uc010xww.1_Nonsense_Mutation_p.Q53*|ZNF227_uc002oyw.2_Nonsense_Mutation_p.Q104*|ZNF227_uc010ejh.2_Nonsense_Mutation_p.Q125*|ZNF235_uc002oyx.1_RNA	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				CAGGTGTCTTCAGGGGAAGAG	0.373													21	46					0	0	0	0	T	44738977	T	T	44738977	4	4	175	1	0	0	0	0	0	1	0	0	17848	827	29	2	408	2	ZNF227	19	44738977	Nonsense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	22747403	44738977	14390006	122	32836											
FBXO46	23403	broad.mit.edu	37	chr19	46215299	46215299	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgcgcgtgggcaggaagctGaagatcttgaccagcacgtg	9	6	16	10	4	1	3	0	2	1	1	1	4	1	4	1	2	2	3	1	2	2	1			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr19:46215299G>A	uc002pcy.2	-	2	1580	c.1455C>T	c.(1453-1455)TTC>TTT	p.F485F	FBXO46_uc002pcz.2_Silent_p.F485F	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	485	F-box.						protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GCAGGAAGCTGAAGATCTTGA	0.632													6	23					0	0	0	0	A	46215299	A	A	46215299	2	1	175	1	0	0	0	0	0	0	0	1	5787	1281	45	2		2	FBXO46	19	46215299	Silent	SNP	G	TCGA-CV-5440-01A-01D-1512-08	1476322	46215299	12913684	123	32837											
SLC12A5	57468	broad.mit.edu	37	chr20	44673612	44673612	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacatcattccaggtttggcGaagctgtgaatggcaacctc	10	10	10	11	1	1	1	1	1	0	0	3	2	2	1	2	3	2	3	2	3	3	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr20:44673612G>A	uc010zxl.1	+	12	1547	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.E468K	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	491	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CAGGTTTGGCGAAGCTGTGAA	0.567													23	94					0	0	0	0	A	44673612	A	A	44673612	3	1	175	1	0	0	0	0	1	0	0	0	14451	1059	37	1	1573	1	SLC12A5	20	44673612	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08		44673612	18351908	124	32838											
NRIP1	8204	broad.mit.edu	37	chr21	16338750	16338750	+	Frame_Shift_Del	DEL	A	-	-																															gcagtatttgttagcttttcAgactgagtactgcagacata																										TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr21:16338750delA	uc002yjx.2	-	4	2362	c.1764delT	c.(1762-1764)TCTfs	p.S588fs		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	588	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TTAGCTTTTCAGACTGAGTAC	0.438													---	---	---								-	16338750	-	-	16338750	7	5	175	1	0	1	0	1	0	0	0	0	10706	175	7	0	1716	0	NRIP1	21	16338750	Frame_Shift_Del	DEL	A	TCGA-CV-5440-01A-01D-1512-08		16338750	31791145	125	32839											
HUNK	30811	broad.mit.edu	37	chr21	33331187	33331187	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatgccatgttgaccgggaCgctgcctttcacggtggagc	6	10	14	11	3	1	1	1	1	0	0	1	3	1	3	3	3	3	3	3	3	1	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr21:33331187C>T	uc002yph.2	+	5	1139	c.779C>T	c.(778-780)ACG>ATG	p.T260M		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	260	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						TTGACCGGGACGCTGCCTTTC	0.542													20	37					0	0	0	0	T	33331187	T	T	33331187	3	4	175	1	0	0	0	0	1	0	0	0	7497	536	19	1	797	1	HUNK	21	33331187	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	16992437	33331187	14798708	126	32840											
COL18A1	80781	broad.mit.edu	37	chr21	46925146	46925146	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgccagggccctcccggcccCccaggccccccagggccccc	3	1	11	26	2	0	0	0	0	0	0	1	0	1	0	11	4	0	0	11	4	0	0			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr21:46925146C>T	uc011afs.1	+	35	4224	c.4203C>T	c.(4201-4203)CCC>CCT	p.P1401P	COL18A1_uc002zhg.2_Silent_p.P986P|COL18A1_uc002zhi.2_Silent_p.P1166P|SLC19A1_uc010gpy.1_Intron|COL18A1_uc002zhj.2_5'UTR|COL18A1_uc002zhk.2_5'Flank	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1404	Triple-helical region 9 (COL9).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CTCCCGGCCCCCCAGGCCCCC	0.731													3	6					0	0	0	0	T	46925146	T	T	46925146	2	4	175	1	0	0	0	0	0	0	0	1	3690	610	22	4		4	COL18A1	21	46925146	Silent	SNP	C	TCGA-CV-5440-01A-01D-1512-08	13593959	46925146	1204749	127	32841											
COL6A1	1291	broad.mit.edu	37	chr21	47423706	47423706	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcgccacgcccgctgccatcGagaaggccgtgcaggaagcc	8	3	14	16	5	0	1	0	0	0	1	1	3	0	2	5	2	3	2	5	2	2	0	rs149534094	byFrequency	TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr21:47423706G>C	uc002zhu.1	+	35	2968	c.2866G>C	c.(2866-2868)GAG>CAG	p.E956Q	COL6A1_uc010gqd.1_Missense_Mutation_p.E287Q|COL6A1_uc002zhv.1_Missense_Mutation_p.E287Q|COL6A1_uc002zhw.1_Missense_Mutation_p.E50Q	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	956	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CGCTGCCATCGAGAAGGCCGT	0.672													8	73					0	0	0	0	C	47423706	C	C	47423706	3	2	175	1	0	0	0	0	1	0	0	0	3714	1059	37	3	3004	3	COL6A1	21	47423706	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08	498560	47423706	706189	128	32842											
FAM116B	414918	broad.mit.edu	37	chr22	50752701	50752701	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgacttgcttaggcaggtctCctacgagacacgcccggtgg	7	9	13	12	3	1	2	0	1	1	1	2	3	1	2	2	4	2	2	2	4	2	3			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chr22:50752701C>G	uc011aru.1	-	14	1145	c.1073G>C	c.(1072-1074)GGA>GCA	p.G358A	FAM116B_uc011arv.1_Missense_Mutation_p.G358A	NM_001001794	NP_001001794	Q8NEG7	F116B_HUMAN	family with sequence similarity 116, member B	358											0		all_cancers(38;4.34e-09)|all_epithelial(38;3.03e-08)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGGCAGGTCTCCTACGAGACA	0.637													3	22					0	0	0	0	G	50752701	G	G	50752701	3	3	175	1	0	0	0	0	1	0	0	0	5436	869	30	2	716	2	FAM116B	22	50752701	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08		50752701	551865	129	32843											
WNK3	65267	broad.mit.edu	37	chrX	54228471	54228471	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctagtttgtgttgactttGtttaagttggtttaaacttg	7	21	9	4	0	1	1	0	1	1	0	1	1	1	1	0	1	1	5	0	1	4	10			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chrX:54228471G>T	uc004dtd.1	-	22	5294	c.4855C>A	c.(4855-4857)CAA>AAA	p.Q1619K	WNK3_uc004dtc.1_Missense_Mutation_p.Q1676K	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1619					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TGTTGACTTTGTTTAAGTTGG	0.338													6	13					5.18039e-06	5.47984e-06	1	0	T	54228471	T	T	54228471	3	4	175	1	0	0	0	0	1	0	0	0	17447	1386	48	4	384	4	WNK3	23	54228471	Missense_Mutation	SNP	G	TCGA-CV-5440-01A-01D-1512-08		54228471	101042089	130	32844											
MORF4L2	9643	broad.mit.edu	37	chrX	102931249	102931249	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcgtataggccaacattgctCcaattcttacaaataatctc	13	12	5	11	1	2	0	0	0	2	0	4	0	3	0	2	1	3	2	2	1	7	6			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chrX:102931249C>G	uc004ekw.2	-	4	1939	c.707G>C	c.(706-708)GGA>GCA	p.G236A	MORF4L2_uc004ela.2_Missense_Mutation_p.G236A|MORF4L2_uc004ekx.2_Missense_Mutation_p.G236A|MORF4L2_uc004elb.2_Missense_Mutation_p.G236A|MORF4L2_uc004eky.2_Missense_Mutation_p.G236A|MORF4L2_uc010nos.2_Missense_Mutation_p.G236A|MORF4L2_uc004ekz.2_Missense_Mutation_p.G236A|MORF4L2_uc011mry.1_Missense_Mutation_p.G236A|MORF4L2_uc011mrz.1_Missense_Mutation_p.G236A|MORF4L2_uc004elc.2_Missense_Mutation_p.G236A|MORF4L2_uc004elf.2_Missense_Mutation_p.G236A|MORF4L2_uc004ele.2_Missense_Mutation_p.G236A|MORF4L2_uc011msa.1_Missense_Mutation_p.G236A|MORF4L2_uc011msb.1_Missense_Mutation_p.G236A|MORF4L2_uc011msc.1_Missense_Mutation_p.G236A|MORF4L2_uc011msd.1_Missense_Mutation_p.G236A|MORF4L2_uc004eld.2_Missense_Mutation_p.G236A	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	236					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						CAACATTGCTCCAATTCTTAC	0.443													4	33					0	0	0	0	G	102931249	G	G	102931249	3	3	175	1	0	0	0	0	1	0	0	0	9760	855	30	2	163	2	MORF4L2	23	102931249	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	48702778	102931249	52339311	131	32845											
DOCK11	139818	broad.mit.edu	37	chrX	117773475	117773475	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctgctcttcgaaacagatCaggagtaatgcaggcccggc	10	7	12	12	2	2	1	1	0	1	1	3	3	2	2	2	3	3	3	2	3	2	2			TCGA-CV-5440-01A-01D-1512-08	TCGA-CV-5440-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f5ba5a9-8089-4fe7-92e3-6c31c5fb32d4	91e50225-73be-4fa0-9abb-61160aaf7490	g.chrX:117773475C>T	uc004eqp.2	+	38	4142	c.4079C>T	c.(4078-4080)TCA>TTA	p.S1360L	DOCK11_uc004eqq.2_Missense_Mutation_p.S1139L	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1360					blood coagulation	cytosol	GTP binding			ovary(3)	3						CGAAACAGATCAGGAGTAATG	0.428													13	15					0	0	0	0	T	117773475	T	T	117773475	3	4	175	1	0	0	0	0	1	0	0	0	4708	838	29	2	4229	2	DOCK11	23	117773475	Missense_Mutation	SNP	C	TCGA-CV-5440-01A-01D-1512-08	14842226	117773475	37497085	132	32846											
C1orf159	54991	broad.mit.edu	37	chr1	1021283	1021283	+	Frame_Shift_Del	DEL	G	-	-																															tttcttctgtagcaggccctGgggagtttactggagcgctt																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:1021283delG	uc001act.2	-	9	1014	c.528delC	c.(526-528)CCCfs	p.P176fs	C1orf159_uc001acu.2_Frame_Shift_Del_p.P140fs|C1orf159_uc001acr.2_RNA|C1orf159_uc001acs.2_RNA|C1orf159_uc010nyd.1_RNA|C1orf159_uc001acm.2_Frame_Shift_Del_p.P140fs|C1orf159_uc009vju.1_Frame_Shift_Del_p.P118fs|C1orf159_uc001acn.2_Frame_Shift_Del_p.P140fs|C1orf159_uc001acp.2_Frame_Shift_Del_p.P140fs	NM_017891	NP_060361	Q96HA4	CA159_HUMAN	hypothetical protein LOC54991	176						integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		AGCAGGCCCTGGGGAGTTTAC	0.627													---	---	---								-	1021283	-	-	1021283	7	5	176	1	0	1	0	1	0	0	0	0	2017	1335	47	0	192	0	C1orf159	1	1021283	Frame_Shift_Del	DEL	G	TCGA-CV-5441-01A-01D-1512-08		1021283	248229338	1	32847											
SKI	6497	broad.mit.edu	37	chr1	2160689	2160689	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaccagctggagatcctcAaagtcatgggcatcctgccc	9	7	10	15	1	2	1	2	0	0	1	4	3	4	1	5	2	2	2	5	2	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:2160689A>T	uc001aja.3	+	1	556	c.484A>T	c.(484-486)AAA>TAA	p.K162*		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	162					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		GGAGATCCTCAAAGTCATGGG	0.662													17	5					0	0	0	0	T	2160689	T	T	2160689	4	4	176	1	0	0	0	0	0	1	0	0	14422	131	5	5	486	5	SKI	1	2160689	Nonsense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	1139406	2160689	247089932	2	32848											
CHD5	26038	broad.mit.edu	37	chr1	6188634	6188634	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggactggacatcagggaTgggtgtgaccggcctctggc	7	7	18	9	1	2	1	1	1	1	0	2	5	2	5	2	7	0	0	2	7	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:6188634T>A	uc001amb.1	-	24	3755	c.3655A>T	c.(3655-3657)ATC>TTC	p.I1219F	CHD5_uc001alz.1_Missense_Mutation_p.I76F|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1219					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		ACATCAGGGATGGGTGTGACC	0.632													21	47					0	0	0	0	A	6188634	A	A	6188634	3	1	176	1	0	0	0	0	1	0	0	0	3343	1464	51	5	2281	5	CHD5	1	6188634	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	4027945	6188634	243061987	3	32849											
NMNAT1	64802	broad.mit.edu	37	chr1	10035807	10035807	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggaaagtcttcagaaggaGtggaaagagactctgaaggt	14	8	15	4	0	3	3	1	1	2	2	3	7	3	6	0	4	0	0	0	4	4	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:10035807G>T	uc001aqp.2	+	3	417	c.273G>T	c.(271-273)GAG>GAT	p.E91D		NM_022787	NP_073624	Q9HAN9	NMNA1_HUMAN	nicotinamide mononucleotide adenylyltransferase	91					water-soluble vitamin metabolic process	nucleoplasm	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding				0		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.31e-08)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(185;0.00028)|BRCA - Breast invasive adenocarcinoma(304;0.00032)|KIRC - Kidney renal clear cell carcinoma(229;0.00101)|STAD - Stomach adenocarcinoma(132;0.00908)|READ - Rectum adenocarcinoma(331;0.0419)		TTCAGAAGGAGTGGAAAGAGA	0.393													46	103					2.72333e-11	3.25793e-11	1	0	T	10035807	T	T	10035807	3	4	176	1	0	0	0	0	1	0	0	0	10552	1020	36	4	279	4	NMNAT1	1	10035807	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3847173	10035807	239214814	4	32850											
TMEM82	388595	broad.mit.edu	37	chr1	16073407	16073407	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagagccaggtgcagacggTgctggtgcgcatgggcggcc	6	5	19	11	3	0	2	0	0	0	2	0	2	0	2	2	5	4	4	2	5	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:16073407T>C	uc001axc.2	+	5	941	c.803T>C	c.(802-804)GTG>GCG	p.V268A		NM_001013641	NP_001013663	A0PJX8	TMM82_HUMAN	transmembrane protein 82	268	Leu-rich.|Helical; (Potential).					integral to membrane				breast(1)|central_nervous_system(1)	2		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTGCAGACGGTGCTGGTGCGC	0.682													17	10					0	0	0	0	C	16073407	C	C	16073407	3	2	176	1	0	0	0	0	1	0	0	0	16272	1696	59	5	821	5	TMEM82	1	16073407	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	6037600	16073407	233177214	5	32851											
CAPZB	832	broad.mit.edu	37	chr1	19712005	19712005	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcatgagctcacctatagGagtccccatctctgttgtag	8	11	11	11	0	2	1	1	1	1	0	4	2	3	2	3	2	1	4	3	2	3	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:19712005G>T	uc010ocz.1	-	3	724	c.296C>A	c.(295-297)TCC>TAC	p.S99Y	CAPZB_uc001bce.2_Missense_Mutation_p.S70Y|CAPZB_uc009vpk.2_Missense_Mutation_p.S96Y|CAPZB_uc001bcd.2_Missense_Mutation_p.S58Y	NM_004930	NP_004921	P47756	CAPZB_HUMAN	F-actin capping protein beta subunit	70					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement	cytosol|F-actin capping protein complex|WASH complex	actin binding				0		Colorectal(325;3.93e-05)|Renal(390;0.000147)|all_lung(284;0.000169)|Lung NSC(340;0.000202)|Breast(348;0.000496)|Ovarian(437;0.00428)|Myeloproliferative disorder(586;0.0262)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Kidney(64;8.63e-06)|BRCA - Breast invasive adenocarcinoma(304;4.06e-05)|KIRC - Kidney renal clear cell carcinoma(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000525)|STAD - Stomach adenocarcinoma(196;0.00779)|READ - Rectum adenocarcinoma(331;0.103)|Lung(427;0.173)		TCACCTATAGGAGTCCCCATC	0.572													17	52					9.16793e-09	1.05533e-08	1	0	T	19712005	T	T	19712005	3	4	176	1	0	0	0	0	1	0	0	0	2655	1174	41	2	637	2	CAPZB	1	19712005	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3638598	19712005	229538616	6	32852											
HSPG2	3339	broad.mit.edu	37	chr1	22205106	22205106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagtgtagcctggggcacagGcgtcacatgtggcttggcca	7	8	15	11	1	1	0	1	0	0	0	1	0	1	0	2	5	1	3	2	5	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:22205106G>A	uc001bfj.2	-	19	2562	c.2522C>T	c.(2521-2523)GCC>GTC	p.A841V	HSPG2_uc009vqd.2_Missense_Mutation_p.A842V	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	841	Laminin EGF-like 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGGGGCACAGGCGTCACATGT	0.627													14	21					0	0	0	0	A	22205106	A	A	22205106	3	1	176	1	0	0	0	0	1	0	0	0	7469	1203	42	4	10969	4	HSPG2	1	22205106	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2493101	22205106	227045515	7	32853											
CSMD2	114784	broad.mit.edu	37	chr1	34066567	34066567	+	Frame_Shift_Del	DEL	G	-	-																															tgttttcttggccatgctccGggtgaagacgccgagccgtg																								rs114879806	byFrequency	TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:34066567delG	uc001bxn.1	-	45	6789	c.6760delC	c.(6760-6762)CGGfs	p.R2254fs	CSMD2_uc001bxm.1_Frame_Shift_Del_p.R2252fs|CSMD2_uc001bxo.1_Frame_Shift_Del_p.R1125fs	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2254	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCCATGCTCCGGGTGAAGACG	0.572													---	---	---								-	34066567	-	-	34066567	7	5	176	1	0	1	0	1	0	0	0	0	3962	1115	39	0	3803	0	CSMD2	1	34066567	Frame_Shift_Del	DEL	G	TCGA-CV-5441-01A-01D-1512-08	11861461	34066567	215184054	8	32854											
EIF2C1	26523	broad.mit.edu	37	chr1	36379547	36379547	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agactctgtccaacctctgcCtcaagatcaatgtcaaactt	12	11	5	13	0	5	2	3	0	2	2	6	2	6	2	3	0	3	0	3	0	4	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:36379547C>T	uc001bzl.2	+	13	1900	c.1687C>T	c.(1687-1689)CTC>TTC	p.L563F	EIF2C1_uc001bzk.2_Missense_Mutation_p.L488F|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	563	Piwi.				negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAACCTCTGCCTCAAGATCAA	0.507													62	117					0	0	0	0	T	36379547	T	T	36379547	3	4	176	1	0	0	0	0	1	0	0	0	5027	681	24	4	1737	4	EIF2C1	1	36379547	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2312980	36379547	212871074	9	32855											
MACF1	23499	broad.mit.edu	37	chr1	39720017	39720017	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cataggctgcagaatgtgcaGattgccctggacttcctaaa	11	10	10	10	0	0	2	0	0	0	2	1	3	1	3	2	2	3	3	2	2	4	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:39720017G>T	uc010ois.1	+	6	625	c.420G>T	c.(418-420)CAG>CAT	p.Q140H	MACF1_uc001cda.1_Missense_Mutation_p.Q48H|MACF1_uc010oit.1_Missense_Mutation_p.Q103H	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	140	Actin-binding.|CH 1.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAATGTGCAGATTGCCCTGG	0.478													35	80					4.34086e-07	4.90953e-07	1	0	T	39720017	T	T	39720017	3	4	176	1	0	0	0	0	1	0	0	0	9195	933	33	2	434	2	MACF1	1	39720017	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3340470	39720017	209530604	10	32856											
LEPRE1	64175	broad.mit.edu	37	chr1	43228142	43228142	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caacagctttctccaacttgTtgatctaagaatgaagcatg	13	12	7	9	0	2	3	0	2	2	1	3	3	2	3	1	0	4	3	1	0	5	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:43228142T>C	uc001chv.2	-	2	583	c.470A>G	c.(469-471)AAC>AGC	p.N157S	LEPRE1_uc001chw.2_Missense_Mutation_p.N157S|LEPRE1_uc001chx.3_Missense_Mutation_p.N157S|LEPRE1_uc001chy.3_Missense_Mutation_p.N157S	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	157	TPR 2.				negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CTCCAACTTGTTGATCTAAGA	0.458													46	92					0	0	0	0	C	43228142	C	C	43228142	3	2	176	1	0	0	0	0	1	0	0	0	8769	1725	60	5	1815	5	LEPRE1	1	43228142	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	3508125	43228142	206022479	11	32857											
USP24	23358	broad.mit.edu	37	chr1	55599818	55599818	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtatcaagagcagaagcttCcgtactcgtagagttatcct	11	11	10	9	2	1	3	1	0	0	3	4	3	3	3	2	1	3	6	2	1	6	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:55599818C>T	uc001cyg.3	-	27	2826	c.2826G>A	c.(2824-2826)CGG>CGA	p.R942R		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1102					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						GCAGAAGCTTCCGTACTCGTA	0.333													18	32					0	0	0	0	T	55599818	T	T	55599818	2	4	176	1	0	0	0	0	0	0	0	1	17123	842	30	2		2	USP24	1	55599818	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	12371676	55599818	193650803	12	32858											
C1orf168	199920	broad.mit.edu	37	chr1	57257960	57257960	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggttcctctggagtaagccCcatgcctttttgcccttcca	5	13	9	14	0	1	0	0	0	1	0	3	1	3	1	6	2	3	2	6	2	1	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:57257960C>A	uc001cym.3	-	2	932	c.526G>T	c.(526-528)GGG>TGG	p.G176W	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Missense_Mutation_p.G176W	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	176										ovary(3)|skin(2)	5						GGAGTAAGCCCCATGCCTTTT	0.488													66	120					1.17004e-41	1.80382e-41	1	0	A	57257960	A	A	57257960	3	1	176	1	0	0	0	0	1	0	0	0	2021	623	22	4	1736	4	C1orf168	1	57257960	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1658142	57257960	191992661	13	32859											
C8B	732	broad.mit.edu	37	chr1	57420448	57420448	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagtttgcttcatctgactgGtctccacagtcattgtcccc	6	14	7	14	0	4	1	2	1	2	0	6	1	5	1	3	1	1	2	3	1	0	3	rs151302643	byFrequency	TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:57420448G>C	uc001cyp.2	-	4	511	c.444C>G	c.(442-444)GAC>GAG	p.D148E	C8B_uc010oon.1_Missense_Mutation_p.D86E|C8B_uc010ooo.1_Missense_Mutation_p.D96E	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	148	LDL-receptor class A.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						CATCTGACTGGTCTCCACAGT	0.448													39	98					0	0	0	0	C	57420448	C	C	57420448	3	2	176	1	0	0	0	0	1	0	0	0	2428	1252	44	4	1367	4	C8B	1	57420448	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	162488	57420448	191830173	14	32860											
DOCK7	85440	broad.mit.edu	37	chr1	62954718	62954718	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tactttgtaaacttcattaaCtgcttcatacatgccagcct	11	15	4	11	0	2	0	2	0	0	0	2	0	2	0	2	0	7	2	2	0	5	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:62954718C>A	uc001daq.2	-	42	5387	c.5353G>T	c.(5353-5355)GTT>TTT	p.V1785F	DOCK7_uc001dan.2_Missense_Mutation_p.V1646F|DOCK7_uc001dao.2_Missense_Mutation_p.V1646F|DOCK7_uc001dap.2_Missense_Mutation_p.V1763F|DOCK7_uc001dam.2_Missense_Mutation_p.V965F|DOCK7_uc010oov.1_Missense_Mutation_p.V524F	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1794	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						ACTTCATTAACTGCTTCATAC	0.299													16	47					4.14922e-12	5.04529e-12	1	0	A	62954718	A	A	62954718	3	1	176	1	0	0	0	0	1	0	0	0	4714	565	20	4	1078	4	DOCK7	1	62954718	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	5534270	62954718	186295903	15	32861											
TNNI3K	51086	broad.mit.edu	37	chr1	75005943	75005943	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaatattcctctcaaggtCtgtctttggaggagatgaaa	12	12	10	7	0	3	2	1	1	3	1	5	5	4	3	1	3	0	0	1	3	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:75005943C>A	uc001dgf.1	+	24	2428	c.2377C>A	c.(2377-2379)CTG>ATG	p.L793M	TNNI3K_uc001dge.1_Missense_Mutation_p.L894M	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	793						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						CTCTCAAGGTCTGTCTTTGGA	0.348													22	61					5.35356e-11	6.34586e-11	1	0	A	75005943	A	A	75005943	3	1	176	1	0	0	0	0	1	0	0	0	16395	912	32	2	2826	2	TNNI3K	1	75005943	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	12051225	75005943	174244678	16	32862											
FUBP1	8880	broad.mit.edu	37	chr1	78429830	78429830	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttatttgtgctatcctttCgggtgttgtcccatcatctt	4	20	8	9	1	2	0	1	0	1	0	5	0	4	0	2	1	1	3	2	1	2	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:78429830C>A	uc001dii.2	-	12	1047	c.958G>T	c.(958-960)GAA>TAA	p.E320*	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Nonsense_Mutation_p.E341*	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	320	KH 3.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						GCTATCCTTTCGGGTGTTGTC	0.348													70	161					8.65233e-54	1.37061e-53	1	0	A	78429830	A	A	78429830	4	1	176	1	0	0	0	0	0	1	0	0	6126	893	31	3	1012	3	FUBP1	1	78429830	Nonsense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	3423887	78429830	170820791	17	32863											
COL24A1	255631	broad.mit.edu	37	chr1	86591713	86591713	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatattgtaaacggctgcccCaagttgactggtaaaatttt	13	13	8	7	1	0	1	0	1	0	0	0	1	0	1	2	2	2	4	2	2	7	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:86591713C>A	uc001dlj.2	-	3	348	c.306G>T	c.(304-306)TTG>TTT	p.L102F	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.L102F	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	102	TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		ACGGCTGCCCCAAGTTGACTG	0.388													39	76					2.2871e-25	3.28176e-25	1	0	A	86591713	A	A	86591713	3	1	176	1	0	0	0	0	1	0	0	0	3698	593	21	4	5070	4	COL24A1	1	86591713	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	8161883	86591713	162658908	18	32864											
GBP5	115362	broad.mit.edu	37	chr1	89726431	89726431	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttattaacagtcctctgggCgtgctggagctcactgagaa	9	11	12	9	1	2	1	1	1	1	1	3	3	3	2	1	2	3	3	1	2	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:89726431C>A	uc001dnc.2	-	12	2254	c.1717G>T	c.(1717-1719)GCC>TCC	p.A573S	GBP5_uc001dnd.2_Missense_Mutation_p.A573S	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	573						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		GTCCTCTGGGCGTGCTGGAGC	0.403													53	165					4.32865e-36	6.61428e-36	1	0	A	89726431	A	A	89726431	3	1	176	1	0	0	0	0	1	0	0	0	6312	768	27	3	47	3	GBP5	1	89726431	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	3134718	89726431	159524190	19	32865											
COL11A1	1301	broad.mit.edu	37	chr1	103343706	103343706	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttcaatgacagtcttttCatagccttttctggactgta	9	17	7	8	0	4	1	2	1	2	0	4	3	4	2	1	1	1	1	1	1	3	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:103343706C>A	uc001dul.2	-	67	5608	c.5290G>T	c.(5290-5292)GAA>TAA	p.E1764*	COL11A1_uc001duk.2_Nonsense_Mutation_p.E960*|COL11A1_uc001dum.2_Nonsense_Mutation_p.E1776*|COL11A1_uc001dun.2_Nonsense_Mutation_p.E1725*|COL11A1_uc009weh.2_Nonsense_Mutation_p.E1648*	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1764	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACAGTCTTTTCATAGCCTTTT	0.303													12	57					3.07112e-06	3.41382e-06	1	0	A	103343706	A	A	103343706	4	1	176	1	0	0	0	0	0	1	0	0	3682	835	29	2	134	2	COL11A1	1	103343706	Nonsense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	13617275	103343706	145906915	20	32866											
WDR3	10885	broad.mit.edu	37	chr1	118481110	118481110	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcttcttttagtgggaaaGataccatggtgaaatggtgg	10	15	12	4	0	2	2	0	1	2	1	2	3	2	3	1	4	1	0	1	4	4	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:118481110G>A	uc010oxe.1	+	5	574	c.508G>A	c.(508-510)GAT>AAT	p.D170N	WDR3_uc001ehi.2_Intron|WDR3_uc001ehh.2_5'UTR	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	170	WD 4.					nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TAGTGGGAAAGATACCATGGT	0.423													27	67					0	0	0	0	A	118481110	A	A	118481110	3	1	176	1	0	0	0	0	1	0	0	0	17353	942	33	2	522	2	WDR3	1	118481110	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	15137404	118481110	130769511	21	32867											
PDE4DIP	9659	broad.mit.edu	37	chr1	144879382	144879382	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttcagatctttgatgtcCtttcgtaggaccaagatgtt	8	15	9	9	1	2	3	1	1	1	2	4	4	3	4	3	1	0	2	3	1	2	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:144879382C>A	uc001elw.3	-	27	4359	c.4068G>T	c.(4066-4068)AAG>AAT	p.K1356N	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.K1312N|PDE4DIP_uc001elv.3_Missense_Mutation_p.K363N	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1356	Potential.			K -> R (in Ref. 4; CAD91152).	cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTTTGATGTCCTTTCGTAGGA	0.493			T	PDGFRB	MPD								74	398					8.07507e-42	1.24862e-41	1	0	A	144879382	A	A	144879382	3	1	176	1	0	0	0	0	1	0	0	0	11697	680	24	4	3044	4	PDE4DIP	1	144879382	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	26398272	144879382	104371239	22	32868											
TDRD10	126668	broad.mit.edu	37	chr1	154516995	154516995	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggacacgcctggaacaggTgtgtgcctgggcaggggtag	8	7	18	8	1	0	0	0	0	0	0	0	2	0	2	2	6	2	2	2	6	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:154516995T>A	uc009wow.2	+	10	1635	c.797_splice	c.e10+2	p.R266_splice	TDRD10_uc001ffd.2_Splice_Site_p.R266_splice|TDRD10_uc001ffe.2_Splice_Site_p.R187_splice	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a								nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTGGAACAGGTGTGTGCCTGG	0.587													5	14					0	0	0	0	A	154516995	A	A	154516995	5	1	176	1	0	0	0	0	0	0	1	0	15797	1710	59	5	833	5	TDRD10	1	154516995	Splice_Site	SNP	T	TCGA-CV-5441-01A-01D-1512-08	9637613	154516995	94733626	23	32869											
PYGO2	90780	broad.mit.edu	37	chr1	154931794	154931794	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcccctgaccaggtctctGgagaggagaagggccaaaag	12	4	15	10	0	1	3	0	1	1	2	2	6	1	3	4	4	1	0	4	4	3	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:154931794G>A	uc001fft.2	-	3	888	c.682C>T	c.(682-684)CAG>TAG	p.Q228*		NM_138300	NP_612157	Q9BRQ0	PYGO2_HUMAN	pygopus homolog 2	228	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			skin(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CCAGGTCTCTGGAGAGGAGAA	0.637													7	39					0	0	0	0	A	154931794	A	A	154931794	4	1	176	1	0	0	0	0	0	1	0	0	12929	1357	47	4	542	4	PYGO2	1	154931794	Nonsense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	414799	154931794	94318827	24	32870											
ASH1L	55870	broad.mit.edu	37	chr1	155340374	155340374	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catgcggtaactgtcaatcaCcatcccactatccaggttca	11	10	6	14	1	3	0	3	0	0	0	5	0	5	0	3	2	2	2	3	2	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:155340374C>A	uc009wqq.2	-	12	7102	c.6622G>T	c.(6622-6624)GTG>TTG	p.V2208L	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.V2203L	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2208	SET.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CTGTCAATCACCATCCCACTA	0.418													66	100					6.75472e-32	9.99699e-32	1	0	A	155340374	A	A	155340374	3	1	176	1	0	0	0	0	1	0	0	0	1043	507	18	4	2355	4	ASH1L	1	155340374	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	408580	155340374	93910247	25	32871											
YY1AP1	55249	broad.mit.edu	37	chr1	155629663	155629663	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttatcgactggtggaggccCtgggctatgttccactttgg	5	14	13	9	1	0	0	0	0	0	0	2	2	1	1	2	5	0	2	2	5	2	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:155629663C>A	uc001fln.2	-	11	2200	c.2176G>T	c.(2176-2178)GGG>TGG	p.G726W	YY1AP1_uc001flg.2_Missense_Mutation_p.G465W|YY1AP1_uc010pgg.1_Missense_Mutation_p.G565W|YY1AP1_uc010pgh.1_Missense_Mutation_p.G669W|YY1AP1_uc010pgi.1_Missense_Mutation_p.G818W|YY1AP1_uc001flh.2_Missense_Mutation_p.G798W|YY1AP1_uc009wqt.2_Missense_Mutation_p.G649W|YY1AP1_uc001flk.2_Missense_Mutation_p.G669W|YY1AP1_uc001fll.2_Missense_Mutation_p.G680W|YY1AP1_uc009wqv.2_Missense_Mutation_p.G397W|YY1AP1_uc001flm.2_Missense_Mutation_p.G669W|YY1AP1_uc001fli.2_Missense_Mutation_p.G680W|YY1AP1_uc009wqu.2_Missense_Mutation_p.G513W|YY1AP1_uc001flj.2_Missense_Mutation_p.G660W|YY1AP1_uc009wqw.2_Missense_Mutation_p.G649W|YY1AP1_uc001flo.2_Missense_Mutation_p.G614W|YY1AP1_uc001flp.2_Missense_Mutation_p.G680W	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	726					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GGTGGAGGCCCTGGGCTATGT	0.512													19	83					1.50039e-11	1.82015e-11	1	0	A	155629663	A	A	155629663	3	1	176	1	0	0	0	0	1	0	0	0	17576	681	24	4	218	4	YY1AP1	1	155629663	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	289289	155629663	93620958	26	32872											
NES	10763	broad.mit.edu	37	chr1	156639196	156639196	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaccctggcccaggtgaacaGgagcccctgcccaagaggtc	9	4	13	15	0	0	2	0	1	0	1	1	4	0	3	5	4	3	0	5	4	2	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:156639196G>A	uc001fpq.2	-	4	4917	c.4784C>T	c.(4783-4785)CCT>CTT	p.P1595L		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1595	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CAGGTGAACAGGAGCCCCTGC	0.597													38	79					0	0	0	0	A	156639196	A	A	156639196	3	1	176	1	0	0	0	0	1	0	0	0	10391	1000	35	4	85	4	NES	1	156639196	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1009533	156639196	92611425	27	32873											
FCER1G	2207	broad.mit.edu	37	chr1	161185043	161185044	+	5'Flank	DEL	TG	-	-																															tggcaggaagagggggactcTgtggtcagggaactgctcgc																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:161185043_161185044delTG	uc001fyz.1	+						FCER1G_uc001fza.1_5'Flank	NM_004106	NP_004097	P30273	FCERG_HUMAN	Fc fragment of IgE, high affinity I, receptor						platelet activation	integral to plasma membrane					0	all_cancers(52;1.35e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Benzylpenicilloyl Polylysine(DB00895)	AGGGGGACTCTGTGGTCAGGGA	0.604													---	---	---								-	161185044	-	-	161185043	6	5	176	0	1	1	0	1	0	0	0	0	5807	1595	55	0		0	FCER1G	1	161185043	5'Flank	DEL	TG	TCGA-CV-5441-01A-01D-1512-08	4545847	161185043	88065578	28	32874											
ASTN1	460	broad.mit.edu	37	chr1	176853475	176853475	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaagtagaaggtgctcacCtgtctccactttggagtggt	9	12	12	8	0	2	2	1	1	1	1	3	3	2	3	2	3	1	2	2	3	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:176853475C>A	uc001glc.2	-	19	3438	c.3226G>T	c.(3226-3228)GAA>TAA	p.E1076*	ASTN1_uc001glb.1_Nonsense_Mutation_p.E1076*|ASTN1_uc001gld.1_Nonsense_Mutation_p.E1076*	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1084	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						AGGTGCTCACCTGTCTCCACT	0.493													43	90					7.70917e-36	1.17452e-35	1	0	A	176853475	A	A	176853475	4	1	176	1	0	0	0	0	0	1	0	0	1066	695	24	4	682	4	ASTN1	1	176853475	Nonsense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	15668432	176853475	72397146	29	32875											
ASTN1	460	broad.mit.edu	37	chr1	176853589	176853589	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcccactccaggaccacaaGagtgctgctgggctcgtgaa	9	8	11	13	1	0	2	0	1	0	1	3	3	2	3	3	2	2	3	3	2	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:176853589G>C	uc001glc.2	-	19	3324	c.3112C>G	c.(3112-3114)CTT>GTT	p.L1038V	ASTN1_uc001glb.1_Missense_Mutation_p.L1038V|ASTN1_uc001gld.1_Missense_Mutation_p.L1038V	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1046	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						AGGACCACAAGAGTGCTGCTG	0.542													36	64					0	0	0	0	C	176853589	C	C	176853589	3	2	176	1	0	0	0	0	1	0	0	0	1066	942	33	2	796	2	ASTN1	1	176853589	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	114	176853589	72397032	30	32876											
FAM5B	57795	broad.mit.edu	37	chr1	177247890	177247890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctctgcaagcgctgccatCgccagcctcgcttccgcctg	5	8	9	19	4	1	0	0	0	1	0	4	0	2	0	6	0	4	3	6	0	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:177247890C>T	uc001glf.2	+	7	1516	c.1204C>T	c.(1204-1206)CGC>TGC	p.R402C	FAM5B_uc010pna.1_Missense_Mutation_p.R152C|FAM5B_uc001glg.2_Missense_Mutation_p.R297C	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	402						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GCGCTGCCATCGCCAGCCTCG	0.617													11	57					0	0	0	0	T	177247890	T	T	177247890	3	4	176	1	0	0	0	0	1	0	0	0	5625	884	31	1	1226	1	FAM5B	1	177247890	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	394301	177247890	72002731	31	32877											
LHX4	89884	broad.mit.edu	37	chr1	180240538	180240538	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actcagaggctggagctaagCggccccggaccaccatcaca	11	4	11	15	2	2	1	2	0	0	1	2	3	2	3	4	4	2	2	4	4	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:180240538C>G	uc001goe.1	+	4	698	c.475C>G	c.(475-477)CGG>GGG	p.R159G	uc001gof.1_RNA	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	159	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TGGAGCTAAGCGGCCCCGGAC	0.587													15	97					0	0	0	0	G	180240538	G	G	180240538	3	3	176	1	0	0	0	0	1	0	0	0	8814	759	27	3	489	3	LHX4	1	180240538	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2992648	180240538	69010083	32	32878											
HMCN1	83872	broad.mit.edu	37	chr1	185833728	185833728	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attaccggctcacccatgagGtgctgcaacttatccaacag	11	9	8	13	1	1	1	1	1	0	0	2	1	2	1	3	2	5	3	3	2	4	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:185833728G>C	uc001grq.1	+	3	695	c.466G>C	c.(466-468)GTG>CTG	p.V156L		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	156	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CACCCATGAGGTGCTGCAACT	0.418													13	27					0	0	0	0	C	185833728	C	C	185833728	3	2	176	1	0	0	0	0	1	0	0	0	7259	1261	44	4	476	4	HMCN1	1	185833728	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	5593190	185833728	63416893	33	32879											
HMCN1	83872	broad.mit.edu	37	chr1	185878573	185878574	+	Frame_Shift_Ins	INS	-	A	A																															ggagaattccttttgatcccINSagcctgaaagaggtcactgt																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:185878573_185878574insA	uc001grq.1	+	5	955_956	c.726_727insA	c.(724-729)CCCAGCfs	p.P242fs		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	242_243					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CTTTTGATCCCAGCCTGAAAGA	0.391													---	---	---								A	185878574	A	A	185878573	7	5	176	1	0	1	1	0	0	0	0	0	7259	581	21	0	744	0	HMCN1	1	185878573	Frame_Shift_Ins	INS	-	TCGA-CV-5441-01A-01D-1512-08	44845	185878573	63372048	34	32880											
REN	5972	broad.mit.edu	37	chr1	204131245	204131245	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctggccatgtccacacctcGttccttcaggctttctcgga	5	12	8	16	2	2	0	1	0	1	0	6	1	4	1	5	3	0	2	5	3	0	3	rs121917741		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:204131245G>T	uc001haq.2	-	2	189	c.145C>A	c.(145-147)CGA>AGA	p.R49R		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	49					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	TCCACACCTCGTTCCTTCAGG	0.542											OREG0014128	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	31					0.000673444	0.000704735	1	0	T	204131245	T	T	204131245	2	4	176	1	0	0	0	0	0	0	0	1	13289	1153	40	3		3	REN	1	204131245	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	18252672	204131245	45119376	35	32881											
ELK4	2005	broad.mit.edu	37	chr1	205585757	205585757	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaatggcccatgactgtTcagtacagaaggaaactgag	14	8	12	7	0	1	4	1	3	0	1	1	5	1	5	1	2	2	2	1	2	4	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:205585757T>C	uc001hcy.1	-	5	2463	c.1213A>G	c.(1213-1215)AAC>GAC	p.N405D		NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	405						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CCATGACTGTTCAGTACAGAA	0.438			T	SLC45A3	prostate								22	85					0	0	0	0	C	205585757	C	C	205585757	3	2	176	1	0	0	0	0	1	0	0	0	5085	1783	62	5	86	5	ELK4	1	205585757	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	1454512	205585757	43664864	36	32882											
C1orf116	79098	broad.mit.edu	37	chr1	207196627	207196627	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctctggcgcaagcctccccGgttctccagggttgtgactg	4	10	13	14	2	2	1	0	1	2	0	4	1	3	1	4	3	1	4	4	3	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:207196627G>A	uc001hfd.2	-	4	741	c.482C>T	c.(481-483)CCG>CTG	p.P161L	C1orf116_uc009xcb.1_5'UTR	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	161						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					AAGCCTCCCCGGTTCTCCAGG	0.602													40	81					0	0	0	0	A	207196627	A	A	207196627	3	1	176	1	0	0	0	0	1	0	0	0	1998	1116	39	1	1327	1	C1orf116	1	207196627	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1610870	207196627	42053994	37	32883											
PTPN14	5784	broad.mit.edu	37	chr1	214542973	214542973	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccttgaacttgccataggtgGctgagctgtgctttgaacct	7	13	11	10	0	0	3	0	3	0	0	0	3	0	3	3	2	5	3	3	2	3	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:214542973G>C	uc001hkk.1	-	17	3369	c.3098C>G	c.(3097-3099)GCC>GGC	p.A1033G		NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	1033	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GCCATAGGTGGCTGAGCTGTG	0.468													61	240					0	0	0	0	C	214542973	C	C	214542973	3	2	176	1	0	0	0	0	1	0	0	0	12846	1203	42	4	477	4	PTPN14	1	214542973	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	7346346	214542973	34707648	38	32884											
PTPN14	5784	broad.mit.edu	37	chr1	214557726	214557726	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgtaggggtgcctctccCgcatctccggttggctgtac	4	11	13	13	2	2	0	0	0	2	0	4	0	2	0	3	4	2	5	3	4	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:214557726C>T	uc001hkk.1	-	13	1743	c.1472G>A	c.(1471-1473)CGG>CAG	p.R491Q	PTPN14_uc010pty.1_Missense_Mutation_p.R392Q	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	491					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GTGCCTCTCCCGCATCTCCGG	0.522													54	193					0	0	0	0	T	214557726	T	T	214557726	3	4	176	1	0	0	0	0	1	0	0	0	12846	652	23	1	2119	1	PTPN14	1	214557726	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	14753	214557726	34692895	39	32885											
USH2A	7399	broad.mit.edu	37	chr1	216258096	216258096	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgggacatccctcccagctgTtatacacgttgatttgttct	7	14	8	12	2	1	1	0	1	1	0	3	2	3	2	2	1	2	4	2	1	2	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:216258096T>G	uc001hku.1	-	25	5498	c.5111A>C	c.(5110-5112)AAC>ACC	p.N1704T		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1704	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTCCCAGCTGTTATACACGTT	0.418										HNSCC(13;0.011)			25	134					0	0	0	0	G	216258096	G	G	216258096	3	3	176	1	0	0	0	0	1	0	0	0	17104	1725	60	5	10689	5	USH2A	1	216258096	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	1700370	216258096	32992525	40	32886											
SLC35F3	148641	broad.mit.edu	37	chr1	234452395	234452395	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcattgtgatgatgacctaCgctgatggcttccacagcca	9	10	11	11	1	0	4	0	4	0	0	1	4	1	4	3	2	2	3	3	2	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:234452395C>T	uc001hwa.1	+	4	897	c.669C>T	c.(667-669)TAC>TAT	p.Y223Y	SLC35F3_uc001hvy.1_Silent_p.Y292Y	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	223	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TGATGACCTACGCTGATGGCT	0.587													45	86					0	0	0	0	T	234452395	T	T	234452395	2	4	176	1	0	0	0	0	0	0	0	1	14654	547	19	1		1	SLC35F3	1	234452395	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	18194299	234452395	14798226	41	32887											
RBM34	23029	broad.mit.edu	37	chr1	235295239	235295239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atttttctttattaacagaaCgcatgactctgagttttctc	10	18	5	8	1	3	3	0	2	3	1	4	3	3	3	0	0	2	2	0	0	3	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:235295239C>T	uc001hwn.2	-	11	1112	c.1082G>A	c.(1081-1083)CGT>CAT	p.R361H	TOMM20_uc001hwl.2_5'Flank|RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	361	RRM 2.					nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			ATTAACAGAACGCATGACTCT	0.313													15	82					0	0	0	0	T	235295239	T	T	235295239	3	4	176	1	0	0	0	0	1	0	0	0	13196	536	19	1	214	1	RBM34	1	235295239	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	842844	235295239	13955382	42	32888											
ACTN2	88	broad.mit.edu	37	chr1	236882193	236882193	+	Splice_Site	DEL	G	-	-																															gattctcttttcatccaacaGgggaaaggctgcccaaacct																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:236882193delG	uc001hyf.2	+	3	446	c.242_splice	c.e3-1	p.G81_splice	ACTN2_uc001hyg.2_Splice_Site|ACTN2_uc009xgi.1_Splice_Site_p.G81_splice	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2						focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TCATCCAACAGGGGAAAGGCT	0.433													---	---	---								-	236882193	-	-	236882193	8	5	176	1	0	1	0	1	0	0	1	0	205	1014	35	0	251	0	ACTN2	1	236882193	Splice_Site	DEL	G	TCGA-CV-5441-01A-01D-1512-08	1586954	236882193	12368428	43	32889											
RYR2	6262	broad.mit.edu	37	chr1	237969512	237969512	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actttttttttgccgctcacCttctcgacattgctatggga	6	17	7	11	2	2	0	1	0	1	0	3	2	2	1	2	1	2	2	2	1	1	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:237969512C>A	uc001hyl.1	+	99	14347	c.14227C>A	c.(14227-14229)CTT>ATT	p.L4743I	RYR2_uc010pyb.1_Missense_Mutation_p.L176I	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4743					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGCCGCTCACCTTCTCGACAT	0.413													16	55					2.32078e-09	2.68941e-09	1	0	A	237969512	A	A	237969512	3	1	176	1	0	0	0	0	1	0	0	0	13834	681	24	4	14621	4	RYR2	1	237969512	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1087319	237969512	11281109	44	32890											
TRIM58	25893	broad.mit.edu	37	chr1	248039216	248039216	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccgcagtggatgtaaagctgGatcccgccacggcgcacccg	8	5	13	15	5	0	0	0	0	0	0	1	2	1	2	4	3	1	4	4	3	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:248039216G>T	uc001ido.2	+	6	934	c.886G>T	c.(886-888)GAT>TAT	p.D296Y	OR2W3_uc001idp.1_5'UTR	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	296	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGTAAAGCTGGATCCCGCCAC	0.542													9	61					1.12685e-05	1.23145e-05	1	0	T	248039216	T	T	248039216	3	4	176	1	0	0	0	0	1	0	0	0	16598	1174	41	2	908	2	TRIM58	1	248039216	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	10069704	248039216	1211405	45	32891											
OR2L2	26246	broad.mit.edu	37	chr1	248202460	248202460	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgagaaacaaggaggtgatGggggccctgacacaagtgat	13	6	15	7	0	0	4	0	4	0	1	0	6	0	5	1	4	1	0	1	4	3	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:248202460G>A	uc001idw.2	+	1	987	c.891G>A	c.(889-891)ATG>ATA	p.M297I	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			AGGAGGTGATGGGGGCCCTGA	0.453													17	94					0	0	0	0	A	248202460	A	A	248202460	3	1	176	1	0	0	0	0	1	0	0	0	11061	1348	47	4	893	4	OR2L2	1	248202460	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	163244	248202460	1048161	46	32892											
OR2L13	284521	broad.mit.edu	37	chr1	248262808	248262808	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggtgggtaactcggccaTgattcacctcatccacgtgg	7	10	11	13	3	2	1	2	1	0	0	5	1	3	1	3	4	1	1	3	4	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:248262808T>C	uc001ids.2	+	3	468	c.131T>C	c.(130-132)ATG>ACG	p.M44T		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			AACTCGGCCATGATTCACCTC	0.488													38	146					0	0	0	0	C	248262808	C	C	248262808	3	2	176	1	0	0	0	0	1	0	0	0	11060	1464	51	5	133	5	OR2L13	1	248262808	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	60348	248262808	987813	47	32893											
OR2M4	26245	broad.mit.edu	37	chr1	248402915	248402915	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttcgagccgtcatccacatgGgctctggggaaagtcgtcgc	7	9	13	12	4	2	0	1	0	1	0	6	2	3	1	2	3	1	1	2	3	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:248402915G>A	uc010pzh.1	+	1	685	c.685G>A	c.(685-687)GGC>AGC	p.G229S		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CATCCACATGGGCTCTGGGGA	0.483													24	33					0	0	0	0	A	248402915	A	A	248402915	3	1	176	1	0	0	0	0	1	0	0	0	11066	1232	43	4	687	4	OR2M4	1	248402915	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	140107	248402915	847706	48	32894											
OR2G6	391211	broad.mit.edu	37	chr1	248685532	248685532	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtggatacgactttcaaCgaggcagaactctttgtggc	9	12	12	8	2	2	1	1	0	1	1	2	4	2	2	0	3	3	1	0	3	3	3	rs77917888	byFrequency	TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:248685532C>A	uc001ien.1	+	1	585	c.585C>A	c.(583-585)AAC>AAA	p.N195K		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGACTTTCAACGAGGCAGAAC	0.473													20	54					1.5548e-18	2.06509e-18	1	0	A	248685532	A	A	248685532	3	1	176	1	0	0	0	0	1	0	0	0	11054	535	19	3	587	3	OR2G6	1	248685532	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	282617	248685532	565089	49	32895											
OR2T11	127077	broad.mit.edu	37	chr1	248790373	248790373	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaatacaatcccggcagcCtcactgttcaccagaagccc	12	7	7	15	1	2	1	2	0	0	1	3	1	3	1	4	1	3	3	4	1	5	3	rs148036216	by1000genomes	TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr1:248790373C>A	uc001ier.1	-	1	57	c.57G>T	c.(55-57)GAG>GAT	p.E19D		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCCCGGCAGCCTCACTGTTCA	0.527													21	18					2.39187e-15	3.02193e-15	1	0	A	248790373	A	A	248790373	3	1	176	1	0	0	0	0	1	0	0	0	11072	680	24	4	897	4	OR2T11	1	248790373	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	104841	248790373	460248	50	32896											
KIDINS220	57498	broad.mit.edu	37	chr2	8871438	8871438	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatcctttttgtcaaggagCgcatccgataaatactcttt	11	14	7	9	2	2	0	1	0	1	0	4	3	4	1	2	1	2	1	2	1	5	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:8871438C>G	uc002qzc.2	-	30	4910	c.4728G>C	c.(4726-4728)GCG>GCC	p.A1576A	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Silent_p.A1477A|KIDINS220_uc002qzb.2_Silent_p.A430A	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1576	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGTCAAGGAGCGCATCCGATA	0.478													40	89					0	0	0	0	G	8871438	G	G	8871438	2	3	176	1	0	0	0	0	0	0	0	1	8310	755	27	3		3	KIDINS220	2	8871438	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08		8871438	234327935	51	32897											
APOB	338	broad.mit.edu	37	chr2	21230877	21230877	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attggacagtccaaaggaagTgaggggtccttctatggtga	11	10	14	6	0	1	2	0	2	1	0	3	4	3	4	2	5	0	0	2	5	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:21230877T>C	uc002red.2	-	26	8991	c.8863A>G	c.(8863-8865)ACT>GCT	p.T2955A		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2955					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCAAAGGAAGTGAGGGGTCCT	0.413													79	178					0	0	0	0	C	21230877	C	C	21230877	3	2	176	1	0	0	0	0	1	0	0	0	785	1696	59	5	4844	5	APOB	2	21230877	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	12359439	21230877	221968496	52	32898											
ATAD2B	54454	broad.mit.edu	37	chr2	23977593	23977593	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaccagttccaggcttgtcGtttttgcctgctctaaaatt	8	15	8	10	1	1	0	0	0	1	0	3	1	2	0	3	1	3	4	3	1	3	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:23977593G>A	uc002rek.3	-	26	4424	c.4130C>T	c.(4129-4131)ACG>ATG	p.T1377M	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Missense_Mutation_p.T617M|ATAD2B_uc002rej.3_Missense_Mutation_p.T545M	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1377							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGCTTGTCGTTTTTGCCTG	0.383													32	57					0	0	0	0	A	23977593	A	A	23977593	3	1	176	1	0	0	0	0	1	0	0	0	1074	1145	40	1	258	1	ATAD2B	2	23977593	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2746716	23977593	219221780	53	32899											
EHD3	30845	broad.mit.edu	37	chr2	31489393	31489393	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtgcgctccaagctgccCaacagtgtgctgggcaagat	9	8	13	11	1	0	1	0	0	0	1	1	1	1	1	2	2	5	4	2	2	3	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:31489393C>T	uc002rnu.2	+	6	2039	c.1431C>T	c.(1429-1431)CCC>CCT	p.P477P	EHD3_uc010ymt.1_3'UTR	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	477	EH.|EF-hand.				blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					CCAAGCTGCCCAACAGTGTGC	0.552													30	67					0	0	0	0	T	31489393	T	T	31489393	2	4	176	1	0	0	0	0	0	0	0	1	5001	581	21	4		4	EHD3	2	31489393	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	7511800	31489393	211709980	54	32900											
FBXO11	80204	broad.mit.edu	37	chr2	48059803	48059804	+	Frame_Shift_Ins	INS	-	T	T																															gctccttgaccactaacacaINStactgcagaaccaactgtag																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:48059803_48059804insT	uc010fbl.2	-	10	1029_1030	c.915_916insA	c.(913-918)GTATGTfs	p.V305fs	FBXO11_uc002rwe.2_Frame_Shift_Ins_p.V305fs|FBXO11_uc002rwf.2_Frame_Shift_Ins_p.V305fs|FBXO11_uc002rwg.1_Frame_Shift_Ins_p.V305fs|FBXO11_uc010fbk.2_5'Flank	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	389_390					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CCACTAACACATACTGCAGAAC	0.332													---	---	---								T	48059804	T	T	48059803	7	5	176	1	0	1	1	0	0	0	0	0	5759	217	8	0	1761	0	FBXO11	2	48059803	Frame_Shift_Ins	INS	-	TCGA-CV-5441-01A-01D-1512-08	16570410	48059803	195139570	55	32901											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48874048	48874048	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgagtccctctccacaaGccctcatggggctctccacc	7	9	8	17	0	3	2	1	2	2	0	6	2	4	2	5	2	1	1	5	2	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:48874048G>A	uc010yol.1	+	5	2863	c.2816G>A	c.(2815-2817)AGC>AAC	p.S939N	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.S986N|GTF2A1L_uc002rws.1_Missense_Mutation_p.S282N|GTF2A1L_uc010yom.1_Missense_Mutation_p.S248N|GTF2A1L_uc002rwt.2_Missense_Mutation_p.S282N	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	939					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CTCTCCACAAGCCCTCATGGG	0.428													23	59					0	0	0	0	A	48874048	A	A	48874048	3	1	176	1	0	0	0	0	1	0	0	0	15383	971	34	4	2983	4	STON1-GTF2A1L	2	48874048	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	814245	48874048	194325325	56	32902											
FSHR	2492	broad.mit.edu	37	chr2	49381449	49381449	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaaggaatctctgtcacCttgctctcttggcagagaaa	11	11	9	10	0	4	2	2	0	2	2	6	4	4	3	1	2	1	2	1	2	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:49381449C>G	uc002rww.2	-	1	182	c.108G>C	c.(106-108)AAG>AAC	p.K36N	FSHR_uc002rwx.2_Missense_Mutation_p.K36N|FSHR_uc010fbn.2_Missense_Mutation_p.K36N|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	36	LRRNT.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TCTCTGTCACCTTGCTCTCTT	0.517									Gonadal_Dysgenesis_46_XX				26	62					0	0	0	0	G	49381449	G	G	49381449	3	3	176	1	0	0	0	0	1	0	0	0	6107	680	24	4	2019	4	FSHR	2	49381449	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	507401	49381449	193817924	57	32903											
C2orf86	51057	broad.mit.edu	37	chr2	63631467	63631467	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggcaccacttgggtggcagCttattaatgaaggcaaaagt	12	10	12	7	0	0	1	0	1	0	0	0	1	0	1	1	4	1	4	1	4	5	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:63631467C>T	uc002sch.2	-	10	1597	c.1151G>A	c.(1150-1152)AGC>AAC	p.S384N	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.S225N|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.S192N|C2orf86_uc002sci.1_Missense_Mutation_p.S360N|C2orf86_uc010fcr.1_Missense_Mutation_p.S274N	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	384	WD 2.				cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						TGGGTGGCAGCTTATTAATGA	0.433													50	99					0	0	0	0	T	63631467	T	T	63631467	3	4	176	1	0	0	0	0	1	0	0	0	2211	797	28	4	1125	4	C2orf86	2	63631467	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	14250018	63631467	179567906	58	32904											
INO80B	83444	broad.mit.edu	37	chr2	74684871	74684871	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccggctgtccccatccGcgccgctacgcttgctcccg	2	8	10	21	6	0	0	0	0	0	0	4	0	4	0	7	1	2	4	7	1	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:74684871G>C	uc002slg.2	+	5	996	c.951G>C	c.(949-951)CCG>CCC	p.P317P	INO80B_uc002slf.1_3'UTR|INO80B_uc010yrr.1_Silent_p.P289P|WBP1_uc002slh.1_Intron|INO80B_uc002sli.1_RNA|INO80B_uc010yrs.1_Silent_p.P335P|WBP1_uc002slj.1_5'Flank|WBP1_uc002slk.1_5'Flank|WBP1_uc002sll.1_5'Flank	NM_031288	NP_112578	Q9C086	IN80B_HUMAN	high mobility group AT-hook 1-like 4	317	HIT-type.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|nucleolus	metal ion binding|protein binding			pancreas(1)	1						GTCCCCATCCGCGCCGCTACG	0.701													17	39					0	0	0	0	C	74684871	C	C	74684871	2	2	176	1	0	0	0	0	0	0	0	1	7786	1074	38	3		3	INO80B	2	74684871	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	11053404	74684871	168514502	59	32905											
REG1A	5967	broad.mit.edu	37	chr2	79349244	79349245	+	Missense_Mutation	DNP	CC	AA	AA																															ctggattggcctccatgaccCcaaaaaggtaggctgcagcc																								rs3181912		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:79349244_79349245CC>AA	uc002snz.2	+	4	417_418	c.314_315CC>AA	c.(313-315)CCC>CAA	p.P105Q	REG1A_uc010ffx.1_3'UTR|REG1A_uc010ysd.1_Missense_Mutation_p.P105Q	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	105	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CTCCATGACCCCAAAAAGGTAG	0.49													25	63					0	0	0	0	AA	79349245	AA	AA	79349244	3	1	176	1	0	0	0	0	1	0	0	0	13275	623	22	4	324	4	REG1A	2	79349244	Missense_Mutation	DNP	CC	TCGA-CV-5441-01A-01D-1512-08	4664373	79349244	163850129	60	32906											
LRRTM1	347730	broad.mit.edu	37	chr2	80530249	80530249	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagcgagtgcagggagatGaggcgcgggaagtgggcgaa	11	3	21	6	4	0	3	0	1	0	2	0	7	0	4	0	4	2	1	0	4	2	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:80530249G>T	uc002sok.1	-	2	966	c.696C>A	c.(694-696)CTC>CTA	p.L232L	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	232	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GCAGGGAGATGAGGCGCGGGA	0.592										HNSCC(69;0.2)			59	111					6.09941e-20	8.35844e-20	1	0	T	80530249	T	T	80530249	2	4	176	1	0	0	0	0	0	0	0	1	9089	1277	45	2		2	LRRTM1	2	80530249	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1181005	80530249	162669124	61	32907											
LRRTM1	347730	broad.mit.edu	37	chr2	80530450	80530450	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgttggcccgcatatgcagCgtggtgagcttccgcagccc	5	8	14	14	4	0	1	0	1	0	0	1	1	1	1	3	2	4	5	3	2	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:80530450C>G	uc002sok.1	-	2	765	c.495G>C	c.(493-495)ACG>ACC	p.T165T	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	165	LRR 4.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GCATATGCAGCGTGGTGAGCT	0.622										HNSCC(69;0.2)			21	59					0	0	0	0	G	80530450	G	G	80530450	2	3	176	1	0	0	0	0	0	0	0	1	9089	755	27	3		3	LRRTM1	2	80530450	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	201	80530450	162668923	62	32908											
CTNNA2	1496	broad.mit.edu	37	chr2	80816488	80816488	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atagctgagcaggtggagatAttccatcaagagaaaagcaa	17	7	11	6	0	1	3	1	1	0	2	2	5	2	3	1	2	3	3	1	2	6	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:80816488A>G	uc010ysh.1	+	14	2072	c.2067A>G	c.(2065-2067)ATA>ATG	p.I689M	CTNNA2_uc010yse.1_Missense_Mutation_p.I689M|CTNNA2_uc010ysf.1_Missense_Mutation_p.I689M|CTNNA2_uc010ysg.1_Missense_Mutation_p.I689M|CTNNA2_uc010ysi.1_Missense_Mutation_p.I321M|CTNNA2_uc010ysj.1_Missense_Mutation_p.I18M	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	689					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AGGTGGAGATATTCCATCAAG	0.493													22	52					0	0	0	0	G	80816488	G	G	80816488	3	3	176	1	0	0	0	0	1	0	0	0	4030	439	16	5	1913	5	CTNNA2	2	80816488	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	286038	80816488	162382885	63	32909											
DNAH6	1768	broad.mit.edu	37	chr2	84784995	84784995	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggaaaaacctgtggaactgGgccaagtttagcagcagtat	14	8	12	7	0	0	0	0	0	0	0	0	2	0	2	2	3	4	4	2	3	6	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:84784995G>A	uc010fgb.2	+	11	1876	c.1739G>A	c.(1738-1740)GGG>GAG	p.G580E	DNAH6_uc002soo.2_Missense_Mutation_p.G159E|DNAH6_uc002sop.2_Missense_Mutation_p.G159E	NM_001370	NP_001361	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy polypeptide 6	580	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1						TGTGGAACTGGGCCAAGTTTA	0.338													41	98					0	0	0	0	A	84784995	A	A	84784995	3	1	176	1	0	0	0	0	1	0	0	0	4627	1232	43	4	1777	4	DNAH6	2	84784995	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3968507	84784995	158414378	64	32910											
TRIM43	129868	broad.mit.edu	37	chr2	96260164	96260164	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacaccatcccatcgaagaGgcagctgaggaacaccgggt	14	4	11	12	2	0	2	0	1	0	1	2	4	1	3	3	3	3	2	3	3	3	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:96260164G>T	uc002suv.2	+	2	529	c.393G>T	c.(391-393)GAG>GAT	p.E131D		NM_138800	NP_620155	Q96BQ3	TRI43_HUMAN	tripartite motif-containing 43	131	Potential.					intracellular	zinc ion binding			ovary(1)	1						CCATCGAAGAGGCAGCTGAGG	0.488													34	76					5.43694e-19	7.2962e-19	1	0	T	96260164	T	T	96260164	3	4	176	1	0	0	0	0	1	0	0	0	16585	991	35	4	395	4	TRIM43	2	96260164	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	11475169	96260164	146939209	65	32911											
ZAP70	7535	broad.mit.edu	37	chr2	98351166	98351166	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtgcgccagggcgtgtaccGcatgcgcaagtatggccgcc	7	6	15	13	5	0	0	0	0	0	0	0	0	0	0	4	2	3	4	4	2	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:98351166G>T	uc002syd.1	+	9	1280	c.1073G>T	c.(1072-1074)CGC>CTC	p.R358L	ZAP70_uc010yvf.1_3'UTR|ZAP70_uc002sye.1_Missense_Mutation_p.R248L|ZAP70_uc002syf.1_Missense_Mutation_p.R51L	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	358	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						GGCGTGTACCGCATGCGCAAG	0.637													46	44					6.31075e-24	9.00542e-24	1	0	T	98351166	T	T	98351166	3	4	176	1	0	0	0	0	1	0	0	0	17582	1087	38	3	1099	3	ZAP70	2	98351166	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2091002	98351166	144848207	66	32912											
EDAR	10913	broad.mit.edu	37	chr2	109547447	109547447	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acggggagccagggcgtctgCgtgcagtcccccacatgggc	6	5	16	14	3	1	0	0	0	1	0	2	1	2	1	3	4	3	1	3	4	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:109547447C>A	uc002teq.3	-	2	455	c.24G>T	c.(22-24)ACG>ACT	p.T8T	EDAR_uc010fjn.2_Silent_p.T8T|EDAR_uc010yws.1_Silent_p.T8T	NM_022336	NP_071731	Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor precursor	8					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			skin(1)	1						AGGGCGTCTGCGTGCAGTCCC	0.582													54	112					3.31993e-32	4.92757e-32	1	0	A	109547447	A	A	109547447	2	1	176	1	0	0	0	0	0	0	0	1	4927	755	27	3		3	EDAR	2	109547447	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	11196281	109547447	133651926	67	32913											
DPP10	57628	broad.mit.edu	37	chr2	116599915	116599915	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacaggaaccagaagaagaTgaataatggactgtatttat	17	9	9	6	0	0	4	0	1	0	3	0	6	0	6	2	2	1	1	2	2	7	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:116599915T>A	uc002tla.1	+	26	2842	c.2385T>A	c.(2383-2385)GAT>GAA	p.D795E	DPP10_uc002tlb.1_Missense_Mutation_p.D745E|DPP10_uc002tlc.1_Missense_Mutation_p.D791E|DPP10_uc002tle.2_Missense_Mutation_p.D799E|DPP10_uc002tlf.1_Missense_Mutation_p.D788E	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	795	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CAGAAGAAGATGAATAATGGA	0.383													31	50					0	0	0	0	A	116599915	A	A	116599915	3	1	176	1	0	0	0	0	1	0	0	0	4749	1461	51	5	2658	5	DPP10	2	116599915	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	7052468	116599915	126599458	68	32914											
INHBB	3625	broad.mit.edu	37	chr2	121107382	121107382	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgtccatgctgtacttcGatgatgagtacaacatcgtc	10	12	8	11	2	0	2	0	2	0	0	4	3	1	2	2	0	4	3	2	0	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:121107382G>T	uc002tmn.2	+	2	1202	c.1156G>T	c.(1156-1158)GAT>TAT	p.D386Y		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	386					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)				GCTGTACTTCGATGATGAGTA	0.607													19	51					1.56452e-12	1.91138e-12	1	0	T	121107382	T	T	121107382	3	4	176	1	0	0	0	0	1	0	0	0	7781	1058	37	3	1162	3	INHBB	2	121107382	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	4507467	121107382	122091991	69	32915											
CNTNAP5	129684	broad.mit.edu	37	chr2	125284996	125284996	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaggttccctggggaattttAgtgatttacacattgatctg	10	15	10	6	0	1	2	0	2	1	0	2	3	2	3	1	3	1	1	1	3	4	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:125284996A>G	uc002tno.2	+	10	1973	c.1609A>G	c.(1609-1611)AGT>GGT	p.S537G	CNTNAP5_uc010flu.2_Missense_Mutation_p.S538G	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	537	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGGGAATTTTAGTGATTTACA	0.423													48	88					0	0	0	0	G	125284996	G	G	125284996	3	3	176	1	0	0	0	0	1	0	0	0	3665	420	15	5	1647	5	CNTNAP5	2	125284996	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	4177614	125284996	117914377	70	32916											
LRP1B	53353	broad.mit.edu	37	chr2	141359046	141359046	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcatccaaggctagcacaTgtggatggtcatcttctgac	10	12	9	10	0	4	1	2	1	2	0	5	2	5	2	1	3	1	2	1	3	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:141359046T>C	uc002tvj.1	-	42	7934	c.6962A>G	c.(6961-6963)CAT>CGT	p.H2321R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2321	Extracellular (Potential).|LDL-receptor class B 24.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGCTAGCACATGTGGATGGTC	0.403										TSP Lung(27;0.18)			15	45					0	0	0	0	C	141359046	C	C	141359046	3	2	176	1	0	0	0	0	1	0	0	0	9005	1464	51	5	7037	5	LRP1B	2	141359046	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	16074050	141359046	101840327	71	32917											
KCNJ3	3760	broad.mit.edu	37	chr2	155555407	155555407	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcagcagcttgtgcccaaGaagaagcggcagcggttcgt	10	6	14	11	3	0	2	0	0	0	2	1	2	0	2	1	2	6	5	1	2	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:155555407G>A	uc002tyv.1	+	1	315	c.120G>A	c.(118-120)AAG>AAA	p.K40K	KCNJ3_uc010zce.1_Silent_p.K40K	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	40	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	TTGTGCCCAAGAAGAAGCGGC	0.617													24	44					0	0	0	0	A	155555407	A	A	155555407	2	1	176	1	0	0	0	0	0	0	0	1	8091	933	33	2		2	KCNJ3	2	155555407	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	14196361	155555407	87643966	72	32918											
KCNJ3	3760	broad.mit.edu	37	chr2	155711434	155711434	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctcatgtcgtcccctttaaTagcaccagccataactaaca	12	11	4	14	1	1	0	1	0	1	0	4	0	2	0	4	0	4	1	4	0	4	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:155711434T>A	uc002tyv.1	+	3	1310	c.1115T>A	c.(1114-1116)ATA>AAA	p.I372K	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	372	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	TCCCCTTTAATAGCACCAGCC	0.413													28	88					0	0	0	0	A	155711434	A	A	155711434	3	1	176	1	0	0	0	0	1	0	0	0	8091	1406	49	5	1125	5	KCNJ3	2	155711434	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	156027	155711434	87487939	73	32919											
GALNT3	2591	broad.mit.edu	37	chr2	166618451	166618451	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgagcgtttcagctgttgCgactgttgctcctagcaacc	6	13	11	11	2	1	1	1	1	0	0	2	2	2	1	2	0	6	6	2	0	2	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:166618451C>A	uc010fph.1	-	4	1189	c.802G>T	c.(802-804)GCA>TCA	p.A268S	GALNT3_uc010fpi.1_Missense_Mutation_p.A268S	NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	268	Catalytic subdomain A.|Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						TCAGCTGTTGCGACTGTTGCT	0.358													23	66					4.54149e-19	6.11036e-19	1	0	A	166618451	A	A	166618451	3	1	176	1	0	0	0	0	1	0	0	0	6249	768	27	3	1131	3	GALNT3	2	166618451	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	10907017	166618451	76580922	74	32920											
XIRP2	129446	broad.mit.edu	37	chr2	168101077	168101077	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaaatctgccaaatggttgTttgaaacccaacctcttgat	12	13	7	9	0	2	3	0	3	2	0	2	3	2	3	3	1	3	2	3	1	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:168101077T>A	uc002udx.2	+	8	3193	c.3175T>A	c.(3175-3177)TTT>ATT	p.F1059I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.F884I|XIRP2_uc010fpq.2_Missense_Mutation_p.F837I|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	884	Xin 15.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAAATGGTTGTTTGAAACCCA	0.318													21	39					0	0	0	0	A	168101077	A	A	168101077	3	1	176	1	0	0	0	0	1	0	0	0	17498	1725	60	5	3205	5	XIRP2	2	168101077	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	1482626	168101077	75098296	75	32921											
XIRP2	129446	broad.mit.edu	37	chr2	168106303	168106303	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aagataagctcaagatggttCccaggaagcaaagagaattt	17	8	10	6	0	1	3	1	0	0	3	2	5	2	4	1	2	2	3	1	2	6	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:168106303C>A	uc002udx.2	+	8	8419	c.8401C>A	c.(8401-8403)CCC>ACC	p.P2801T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.P2626T|XIRP2_uc010fpq.2_Missense_Mutation_p.P2579T|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.P147T	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2626					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAAGATGGTTCCCAGGAAGCA	0.408													29	45					1.80694e-10	2.12727e-10	1	0	A	168106303	A	A	168106303	3	1	176	1	0	0	0	0	1	0	0	0	17498	855	30	2	8431	2	XIRP2	2	168106303	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	5226	168106303	75093070	76	32922											
LRP2	4036	broad.mit.edu	37	chr2	170013897	170013897	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacctagacaggaggttctGtcaaaaacattggtttcgaa	13	11	9	8	1	2	1	1	0	1	1	3	3	2	2	1	3	2	2	1	3	5	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:170013897G>A	uc002ues.2	-	64	12216	c.12003C>T	c.(12001-12003)GAC>GAT	p.D4001D		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4001	EGF-like 14.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGGAGGTTCTGTCAAAAACAT	0.383													19	39					0	0	0	0	A	170013897	A	A	170013897	2	1	176	1	0	0	0	0	0	0	0	1	9006	1368	48	4		4	LRP2	2	170013897	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1907594	170013897	73185476	77	32923											
SLC25A12	8604	broad.mit.edu	37	chr2	172669945	172669945	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaacaacagagccagagcCacgctggttttgcattcggg	10	7	11	13	2	0	2	0	0	0	2	1	2	0	2	3	2	5	3	3	2	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:172669945C>A	uc002uhh.2	-	11	1164	c.1075G>T	c.(1075-1077)GGC>TGC	p.G359C	SLC25A12_uc010fqh.2_Missense_Mutation_p.G252C	NM_003705	NP_003696	O75746	CMC1_HUMAN	solute carrier family 25, member 12	359	Solcar 1.				gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	GAGCCAGAGCCACGCTGGTTT	0.443													52	166					6.9144e-35	1.04118e-34	1	0	A	172669945	A	A	172669945	3	1	176	1	0	0	0	0	1	0	0	0	14538	594	21	4	993	4	SLC25A12	2	172669945	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2656048	172669945	70529428	78	32924											
GPR155	151556	broad.mit.edu	37	chr2	175333771	175333771	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgggagcagacacaaatgTgcttatcaccatccctgagg	12	8	11	10	0	1	2	1	1	0	1	2	4	2	3	2	2	2	2	2	2	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:175333771T>C	uc002uit.2	-	6	1442	c.1051A>G	c.(1051-1053)ACA>GCA	p.T351A	GPR155_uc002uiu.2_Missense_Mutation_p.T351A|GPR155_uc002uiv.2_Missense_Mutation_p.T351A|GPR155_uc010fqs.2_Missense_Mutation_p.T351A	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	351	Helical; (Potential).				intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						GACACAAATGTGCTTATCACC	0.398													28	79					0	0	0	0	C	175333771	C	C	175333771	3	2	176	1	0	0	0	0	1	0	0	0	6698	1696	59	5	1609	5	GPR155	2	175333771	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	2663826	175333771	67865602	79	32925											
TTN	7273	broad.mit.edu	37	chr2	179462734	179462734	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaatttgtagaatgctccttCctttaatcctgtcacaacaa	13	14	4	10	0	1	1	1	0	0	1	4	1	4	1	3	0	2	2	3	0	6	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:179462734C>A	uc010zfg.1	-	242	49683	c.49459G>T	c.(49459-49461)GAA>TAA	p.E16487*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.E10182*|TTN_uc010zfi.1_Nonsense_Mutation_p.E10115*|TTN_uc010zfj.1_Nonsense_Mutation_p.E9990*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17414							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATGCTCCTTCCTTTAATCCT	0.388													66	187					4.83874e-46	7.57241e-46	1	0	A	179462734	A	A	179462734	4	1	176	1	0	0	0	0	0	1	0	0	16803	864	30	2	50810	2	TTN	2	179462734	Nonsense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	4128963	179462734	63736639	80	32926											
TTN	7273	broad.mit.edu	37	chr2	179578813	179578813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaccacttagtactgagttCaggggtgccagctactgtac	11	10	10	10	0	1	1	1	1	0	0	1	1	1	1	2	2	6	4	2	2	5	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:179578813C>T	uc010zfg.1	-	89	23064	c.22840G>A	c.(22840-22842)GAA>AAA	p.E7614K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E4275K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8541							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTACTGAGTTCAGGGGTGCCA	0.413													19	46					0	0	0	0	T	179578813	T	T	179578813	3	4	176	1	0	0	0	0	1	0	0	0	16803	835	29	2	78041	2	TTN	2	179578813	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	116079	179578813	63620560	81	32927											
COL3A1	1281	broad.mit.edu	37	chr2	189852852	189852852	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggtacatctggtcatcctGgttcccctgtaagtatagcc	7	13	9	12	0	2	0	1	0	1	0	4	0	4	0	4	3	2	4	4	3	4	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:189852852G>T	uc002uqj.1	+	6	691	c.574G>T	c.(574-576)GGT>TGT	p.G192C		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	192	Triple-helical region.		G -> V (in EDS4).		axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGGTCATCCTGGTTCCCCTGT	0.398													39	100					4.90776e-07	5.52656e-07	1	0	T	189852852	T	T	189852852	3	4	176	1	0	0	0	0	1	0	0	0	3703	1348	47	4	596	4	COL3A1	2	189852852	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	10274039	189852852	53346521	82	32928											
SLC39A10	57181	broad.mit.edu	37	chr2	196544871	196544871	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgaccatggccctgaagcGcttcacagacagcatcgtgg	10	7	11	13	2	1	3	1	2	0	1	2	3	1	3	2	2	2	2	2	2	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:196544871G>A	uc002utg.3	+	2	319	c.105G>A	c.(103-105)GCG>GCA	p.A35A	SLC39A10_uc002uth.3_Silent_p.A35A|SLC39A10_uc010zgp.1_Intron	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	35	His-rich.				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			GCCCTGAAGCGCTTCACAGAC	0.368													26	46					0	0	0	0	A	196544871	A	A	196544871	2	1	176	1	0	0	0	0	0	0	0	1	14677	1074	38	1		1	SLC39A10	2	196544871	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	6692019	196544871	46654502	83	32929											
HECW2	57520	broad.mit.edu	37	chr2	197184265	197184265	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcttgtgtcagtgggaaaaCtactcctcagtttcggagag	9	12	12	8	1	3	1	2	0	1	1	5	3	4	2	1	2	2	1	1	2	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:197184265C>A	uc002utm.1	-	9	1532	c.1349G>T	c.(1348-1350)AGT>ATT	p.S450I	HECW2_uc002utl.1_Missense_Mutation_p.S94I	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	450					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						AGTGGGAAAACTACTCCTCAG	0.498													24	63					5.35356e-11	6.34586e-11	1	0	A	197184265	A	A	197184265	3	1	176	1	0	0	0	0	1	0	0	0	7082	565	20	4	3453	4	HECW2	2	197184265	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	639394	197184265	46015108	84	32930											
SATB2	23314	broad.mit.edu	37	chr2	200173595	200173595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctggggaaggttcaggaagCgacggatggtacagaggttt	10	8	18	5	2	1	1	1	0	0	1	1	5	1	4	0	7	2	4	0	7	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:200173595C>T	uc002uuy.1	-	10	2445	c.1628G>A	c.(1627-1629)CGC>CAC	p.R543H	SATB2_uc010fsq.1_Missense_Mutation_p.R425H|SATB2_uc002uuz.1_Missense_Mutation_p.R543H|SATB2_uc002uva.1_Missense_Mutation_p.R543H	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	543	CUT 2.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTTCAGGAAGCGACGGATGGT	0.572													5	112					0	0	0	0	T	200173595	T	T	200173595	3	4	176	1	0	0	0	0	1	0	0	0	13919	768	27	1	581	1	SATB2	2	200173595	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2989330	200173595	43025778	85	32931											
MDH1B	130752	broad.mit.edu	37	chr2	207621698	207621698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctctttttctatatgtgcccCcaggttctcttgagcaatta	7	17	6	11	0	3	1	0	1	3	0	4	1	3	1	2	1	2	2	2	1	4	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:207621698C>T	uc002vbs.2	-	4	392	c.337G>A	c.(337-339)GGG>AGG	p.G113R	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.G113R|MDH1B_uc010fuj.2_Missense_Mutation_p.G15R|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	113					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		ATATGTGCCCCCAGGTTCTCT	0.443													31	76					0	0	0	0	T	207621698	T	T	207621698	3	4	176	1	0	0	0	0	1	0	0	0	9462	623	22	4	1255	4	MDH1B	2	207621698	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	7448103	207621698	35577675	86	32932											
MDH1B	130752	broad.mit.edu	37	chr2	207621966	207621966	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agttaacttatatacctgagCatgctccaggaactcattat	13	13	6	9	0	1	1	1	1	0	0	2	2	2	2	2	1	5	3	2	1	6	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:207621966C>A	uc002vbs.2	-	3	320	c.265G>T	c.(265-267)GCT>TCT	p.A89S	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.A89S|MDH1B_uc010fuj.2_5'UTR|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	89					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TATACCTGAGCATGCTCCAGG	0.363													25	92					3.7963e-18	4.96587e-18	1	0	A	207621966	A	A	207621966	3	1	176	1	0	0	0	0	1	0	0	0	9462	710	25	4	1331	4	MDH1B	2	207621966	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	268	207621966	35577407	87	32933											
VWC2L	402117	broad.mit.edu	37	chr2	215279018	215279018	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agactatcctgctgatgaagGtgaccagatctccagtaatg	12	10	10	9	0	1	5	0	3	1	2	3	5	2	5	3	1	1	2	3	1	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:215279018G>A	uc002vet.2	+	2	231	c.101G>A	c.(100-102)GGT>GAT	p.G34D	VWC2L_uc010zjl.1_Missense_Mutation_p.G34D	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	34						extracellular region					0						GCTGATGAAGGTGACCAGATC	0.448													28	55					0	0	0	0	A	215279018	A	A	215279018	3	1	176	1	0	0	0	0	1	0	0	0	17312	1261	44	4	103	4	VWC2L	2	215279018	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	7657052	215279018	27920355	88	32934											
ABCA12	26154	broad.mit.edu	37	chr2	215843554	215843554	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacggtggtatctgaaatgcCgtagcacccgatgttgaggt	9	10	13	9	3	1	2	0	2	1	0	1	3	1	2	2	3	2	4	2	3	3	3	rs28940568		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:215843554C>T	uc002vew.2	-	32	5171	c.4951G>A	c.(4951-4953)GGC>AGC	p.G1651S	ABCA12_uc002vev.2_Missense_Mutation_p.G1333S|ABCA12_uc010zjn.1_Missense_Mutation_p.G578S	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1651					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCTGAAATGCCGTAGCACCCG	0.458													30	90					0	0	0	0	T	215843554	T	T	215843554	3	4	176	1	0	0	0	0	1	0	0	0	30	652	23	1	2924	1	ABCA12	2	215843554	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	564536	215843554	27355819	89	32935											
DOCK10	55619	broad.mit.edu	37	chr2	225740756	225740756	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcttcatatgctctcaccCagacccagatcagtgagctc	9	9	8	15	1	3	3	3	1	1	2	5	3	3	3	2	1	2	3	2	1	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:225740756C>A	uc010fwz.1	-	8	1169	c.930G>T	c.(928-930)CTG>CTT	p.L310L	DOCK10_uc002vob.2_Silent_p.L304L|DOCK10_uc002vod.1_Silent_p.L310L	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	310							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGCTCTCACCCAGACCCAGAT	0.517													20	87					8.10497e-08	9.24752e-08	1	0	A	225740756	A	A	225740756	2	1	176	1	0	0	0	0	0	0	0	1	4707	608	21	4		4	DOCK10	2	225740756	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	9897202	225740756	17458617	90	32936											
KIAA1486	57624	broad.mit.edu	37	chr2	226446802	226446802	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccggaggacgtcgctgccGcgggactcctccttgtccca	4	7	12	18	5	0	0	0	0	0	0	4	3	3	3	6	3	1	1	6	3	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:226446802G>A	uc002voe.2	+	4	844	c.669G>A	c.(667-669)CCG>CCA	p.P223P	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_5'UTR	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	223										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		CGTCGCTGCCGCGGGACTCCT	0.582													16	211					0	0	0	0	A	226446802	A	A	226446802	2	1	176	1	0	0	0	0	0	0	0	1	8276	1074	38	1		1	KIAA1486	2	226446802	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	706046	226446802	16752571	91	32937											
NMUR1	10316	broad.mit.edu	37	chr2	232390072	232390072	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgtccactgtgacacgacGctccacatgacgcggtcggc	7	8	11	15	5	1	2	0	2	1	0	4	3	3	2	2	2	0	1	2	2	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:232390072G>C	uc002vry.3	-	3	1073	c.963C>G	c.(961-963)AGC>AGG	p.S321R		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	321	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		GTGACACGACGCTCCACATGA	0.657													28	64					0	0	0	0	C	232390072	C	C	232390072	3	2	176	1	0	0	0	0	1	0	0	0	10560	1078	38	3	321	3	NMUR1	2	232390072	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	5943270	232390072	10809301	92	32938											
ESPNL	339768	broad.mit.edu	37	chr2	239040038	239040038	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acctgggcacccacggctggGaggctgtgcgcgccttccac	5	6	14	16	3	0	0	0	0	0	0	1	1	1	1	4	4	1	3	4	4	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr2:239040038G>C	uc002vxq.3	+	9	2793	c.2683G>C	c.(2683-2685)GAG>CAG	p.E895Q	ESPNL_uc010fyw.2_Missense_Mutation_p.E591Q	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	895										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CCACGGCTGGGAGGCTGTGCG	0.687													5	13					0	0	0	0	C	239040038	C	C	239040038	3	2	176	1	0	0	0	0	1	0	0	0	5279	1175	41	2	2717	2	ESPNL	2	239040038	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	6649966	239040038	4159335	93	32939											
CNTN4	152330	broad.mit.edu	37	chr3	3067852	3067852	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagagagtattgttttacCgtgccaggtaacgcatgatc	10	12	12	7	2	0	2	0	1	0	1	1	4	0	3	2	2	3	4	2	2	3	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:3067852C>A	uc003bpc.2	+	14	1774	c.1553C>A	c.(1552-1554)CCG>CAG	p.P518Q	CNTN4_uc003bpb.1_Missense_Mutation_p.P190Q|CNTN4_uc003bpd.1_Missense_Mutation_p.P518Q|CNTN4_uc003bpe.2_Missense_Mutation_p.P190Q|CNTN4_uc003bpf.2_Missense_Mutation_p.P190Q	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	518	Ig-like C2-type 6.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ATTGTTTTACCGTGCCAGGTA	0.423													22	59					7.41877e-09	8.55963e-09	1	0	A	3067852	A	A	3067852	3	1	176	1	0	0	0	0	1	0	0	0	3658	652	23	3	1599	3	CNTN4	3	3067852	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08		3067852	194954578	94	32940											
GALNTL2	117248	broad.mit.edu	37	chr3	16268961	16268961	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgtgtgatggaaaagcccGccagcagtggcgttttgacc	8	9	13	11	3	0	2	0	2	0	0	1	3	1	3	4	2	2	2	4	2	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:16268961G>T	uc003car.3	+	10	2349	c.1874G>T	c.(1873-1875)CGC>CTC	p.R625L	GALNTL2_uc003caq.3_Missense_Mutation_p.R358L|GALNTL2_uc003cas.3_Missense_Mutation_p.R155L	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	625	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						GGAAAAGCCCGCCAGCAGTGG	0.443													35	71					1.06647e-15	1.35733e-15	1	0	T	16268961	T	T	16268961	3	4	176	1	0	0	0	0	1	0	0	0	6257	1087	38	3	1912	3	GALNTL2	3	16268961	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	13201109	16268961	181753469	95	32941											
STAC	6769	broad.mit.edu	37	chr3	36524549	36524549	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatccaccacaagtgcacaGatggcctggcaccccagcgg	10	4	11	16	1	0	1	0	0	0	1	1	1	1	1	5	3	2	3	5	3	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:36524549G>A	uc003cgh.1	+	3	493	c.454G>A	c.(454-456)GAT>AAT	p.D152N	STAC_uc010hgd.1_RNA|STAC_uc011aya.1_Intron	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	152	Phorbol-ester/DAG-type.				intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						CAAGTGCACAGATGGCCTGGC	0.557													22	62					0	0	0	0	A	36524549	A	A	36524549	3	1	176	1	0	0	0	0	1	0	0	0	15305	942	33	2	464	2	STAC	3	36524549	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	20255588	36524549	161497881	96	32942											
CX3CR1	1524	broad.mit.edu	37	chr3	39307932	39307932	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaagaccacgatgtccccAatataacaggcctcagccaa	15	5	6	15	1	1	1	1	0	0	1	2	2	2	1	6	1	2	0	6	1	5	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:39307932A>T	uc003cjl.2	-	2	161	c.69T>A	c.(67-69)ATT>ATA	p.I23I		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	23	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CGATGTCCCCAATATAACAGG	0.458													15	39					0	0	0	0	T	39307932	T	T	39307932	2	4	176	1	0	0	0	0	0	0	0	1	4092	126	5	5		5	CX3CR1	3	39307932	Silent	SNP	A	TCGA-CV-5441-01A-01D-1512-08	2783383	39307932	158714498	97	32943											
SETD2	29072	broad.mit.edu	37	chr3	47147518	47147518	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagggccatgaaatagtaaTggatgtttttgtttcgtgca	10	15	11	5	1	1	1	1	1	0	0	2	2	1	2	1	2	1	4	1	2	3	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:47147518T>C	uc003cqs.2	-	6	4861	c.4808A>G	c.(4807-4809)CAT>CGT	p.H1603R	SETD2_uc003cqv.2_Missense_Mutation_p.H1592R	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1603	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GAAATAGTAATGGATGTTTTT	0.398			N|F|S|Mis		clear cell renal carcinoma								43	142					0	0	0	0	C	47147518	C	C	47147518	3	2	176	1	0	0	0	0	1	0	0	0	14196	1464	51	5	2950	5	SETD2	3	47147518	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	7839586	47147518	150874912	98	32944											
SLC25A20	788	broad.mit.edu	37	chr3	48896061	48896061	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cattaggatatttcccaggaGgtgctgtggggcagaaccca	10	9	13	9	0	0	1	0	0	0	1	1	3	1	3	2	5	2	2	2	5	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:48896061G>C	uc003cva.3	-	8	897	c.722C>G	c.(721-723)CCT>CGT	p.P241R	SLC25A20_uc011bbw.1_Missense_Mutation_p.P191R|SLC25A20_uc010hkj.2_Missense_Mutation_p.P168R	NM_000387	NP_000378	O43772	MCAT_HUMAN	carnitine/acylcarnitine translocase	241	Solcar 3.|Mitochondrial matrix (Potential).				carnitine shuttle|cellular lipid metabolic process|regulation of fatty acid oxidation	integral to membrane|mitochondrial inner membrane	acyl carnitine transporter activity				0				BRCA - Breast invasive adenocarcinoma(193;0.000168)|Kidney(197;0.00231)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	L-Carnitine(DB00583)	TTTCCCAGGAGGTGCTGTGGG	0.483													25	107					0	0	0	0	C	48896061	C	C	48896061	3	2	176	1	0	0	0	0	1	0	0	0	14547	1000	35	4	191	4	SLC25A20	3	48896061	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1748543	48896061	149126369	99	32945											
AMIGO3	386724	broad.mit.edu	37	chr3	49755534	49755534	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccggcctggctccagaaaGactacgtgcttgtggacgct	7	9	12	13	3	0	2	0	0	0	2	2	3	2	3	3	3	2	3	3	3	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:49755534G>A	uc003cxj.2	-	1	1705	c.1365C>T	c.(1363-1365)GTC>GTT	p.V455V	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	455	Cytoplasmic (Potential).				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCTCCAGAAAGACTACGTGCT	0.637													39	75					0	0	0	0	A	49755534	A	A	49755534	2	1	176	1	0	0	0	0	0	0	0	1	577	929	33	2		2	AMIGO3	3	49755534	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	859473	49755534	148266896	100	32946											
MST1R	4486	broad.mit.edu	37	chr3	49935550	49935550	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacagtgacctgatgggttCcctcaggcaccagaccagaa	11	6	10	14	0	1	4	1	2	0	2	2	4	2	4	5	2	0	2	5	2	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:49935550C>A	uc003cxy.3	-	5	2078	c.1814G>T	c.(1813-1815)GGA>GTA	p.G605V	MST1R_uc011bdd.1_Missense_Mutation_p.G605V|MST1R_uc011bde.1_Missense_Mutation_p.G605V|MST1R_uc011bdf.1_Missense_Mutation_p.G499V|MST1R_uc011bdc.1_5'Flank	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	605	IPT/TIG 1.|Extracellular (Potential).				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CTGATGGGTTCCCTCAGGCAC	0.577													26	63					1.33986e-20	1.84587e-20	1	0	A	49935550	A	A	49935550	3	1	176	1	0	0	0	0	1	0	0	0	9944	855	30	2	2452	2	MST1R	3	49935550	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	180016	49935550	148086880	101	32947											
ERC2	26059	broad.mit.edu	37	chr3	56330328	56330328	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatgctcggcttggagccGcctaaagttctcctcggtca	6	11	11	13	3	3	0	2	0	1	0	6	1	3	1	3	3	2	3	3	3	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:56330328G>A	uc003dhr.1	-	3	1049	c.793C>T	c.(793-795)CGG>TGG	p.R265W		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	265	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GCTTGGAGCCGCCTAAAGTTC	0.542													57	141					0	0	0	0	A	56330328	A	A	56330328	3	1	176	1	0	0	0	0	1	0	0	0	5235	1086	38	1	2130	1	ERC2	3	56330328	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	6394778	56330328	141692102	102	32948											
PDZRN3	23024	broad.mit.edu	37	chr3	73433074	73433074	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatcagctgcatgtagctCtggtagtgctgggcgtgcgc	5	11	16	9	2	2	0	1	0	1	0	2	1	2	1	0	3	5	6	0	3	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:73433074C>A	uc003dpl.1	-	10	2739	c.2643G>T	c.(2641-2643)CAG>CAT	p.Q881H	PDZRN3_uc011bgh.1_Missense_Mutation_p.Q538H|PDZRN3_uc010hoe.1_Missense_Mutation_p.Q579H|PDZRN3_uc011bgf.1_Missense_Mutation_p.Q598H|PDZRN3_uc011bgg.1_Missense_Mutation_p.Q601H	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	881							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GCATGTAGCTCTGGTAGTGCT	0.642													29	69					7.6516e-34	1.14553e-33	1	0	A	73433074	A	A	73433074	3	1	176	1	0	0	0	0	1	0	0	0	11763	912	32	2	561	2	PDZRN3	3	73433074	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	17102746	73433074	124589356	103	32949											
ROBO2	6092	broad.mit.edu	37	chr3	77147180	77147180	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaggatcgcgtcttcgccAggaggactttcccccgcgga	6	9	13	13	5	1	0	0	0	1	0	4	4	2	4	3	4	0	1	3	4	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:77147180A>T	uc003dpy.3	+	2	720	c.77A>T	c.(76-78)CAG>CTG	p.Q26L	ROBO2_uc003dpz.2_Missense_Mutation_p.Q26L|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.Q26L	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	26	Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CGTCTTCGCCAGGAGGACTTT	0.527													6	14					0	0	0	0	T	77147180	T	T	77147180	3	4	176	1	0	0	0	0	1	0	0	0	13579	188	7	5	85	5	ROBO2	3	77147180	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	3714106	77147180	120875250	104	32950											
C3orf38	285237	broad.mit.edu	37	chr3	88202621	88202621	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacatccacctatttcaacaGgtaaaataaatcttatggtt	15	13	5	8	0	2	0	1	0	1	0	3	1	3	0	2	2	1	2	2	2	7	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:88202621G>T	uc003dqw.2	+	3	686	c.375G>T	c.(373-375)CAG>CAT	p.Q125H		NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	125					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TATTTCAACAGGTAAAATAAA	0.383													14	36					0.000219431	0.000233399	1	0	T	88202621	T	T	88202621	3	4	176	1	0	0	0	0	1	0	0	0	2238	1014	35	4	381	4	C3orf38	3	88202621	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	11055441	88202621	109819809	105	32951											
DPPA4	55211	broad.mit.edu	37	chr3	109049520	109049520	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtggaattttccagggcaGgcggctcccccacaggagga	9	6	14	12	1	0	0	0	0	0	0	2	3	2	3	3	6	0	2	3	6	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:109049520G>T	uc003dxq.3	-	5	585	c.530C>A	c.(529-531)CCT>CAT	p.P177H	DPPA4_uc011bho.1_Intron|DPPA4_uc011bhp.1_Missense_Mutation_p.P177H	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	177						nucleus	protein binding			upper_aerodigestive_tract(1)	1						TTCCAGGGCAGGCGGCTCCCC	0.512													43	105					8.20599e-20	1.11861e-19	1	0	T	109049520	T	T	109049520	3	4	176	1	0	0	0	0	1	0	0	0	4758	1000	35	4	396	4	DPPA4	3	109049520	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	20846899	109049520	88972910	106	32952											
ZBTB20	26137	broad.mit.edu	37	chr3	114069727	114069727	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttcagcctggctgtcccGcgccgccccaggcccaaact	5	6	12	18	3	1	0	1	0	0	0	2	0	2	0	6	3	2	2	6	3	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:114069727G>T	uc003ebi.2	-	4	1378	c.1198C>A	c.(1198-1200)CGG>AGG	p.R400R	ZBTB20_uc003ebj.2_Silent_p.R327R|ZBTB20_uc010hqp.2_Silent_p.R327R|ZBTB20_uc003ebk.2_Silent_p.R327R|ZBTB20_uc003ebl.2_Silent_p.R327R|ZBTB20_uc003ebm.2_Silent_p.R327R|ZBTB20_uc003ebn.2_Silent_p.R327R|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		TGGCTGTCCCGCGCCGCCCCA	0.647													35	71					3.76114e-14	4.68334e-14	1	0	T	114069727	T	T	114069727	2	4	176	1	0	0	0	0	0	0	0	1	17596	1086	38	3		3	ZBTB20	3	114069727	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	5020207	114069727	83952703	107	32953											
PLXND1	23129	broad.mit.edu	37	chr3	129289977	129289977	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttggggaggtagtccaggCggaacctgctgccccgctgt	5	8	17	11	2	0	0	0	0	0	0	1	2	1	2	4	6	3	4	4	6	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:129289977C>T	uc003emx.2	-	18	3606	c.3506G>A	c.(3505-3507)CGC>CAC	p.R1169H		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1169	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						GTAGTCCAGGCGGAACCTGCT	0.632													63	189					0	0	0	0	T	129289977	T	T	129289977	3	4	176	1	0	0	0	0	1	0	0	0	12182	768	27	1	2347	1	PLXND1	3	129289977	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	15220250	129289977	68732453	108	32954											
TXNDC6	347736	broad.mit.edu	37	chr3	138025304	138025304	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtttaatgatggccaaggtaCaggtcctctctgatgaaact	11	12	10	8	0	1	3	0	3	1	0	3	3	2	3	2	3	2	2	2	3	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:138025304C>A	uc003esg.2	-	7	507	c.479G>T	c.(478-480)TGT>TTT	p.C160F	TXNDC6_uc003esd.1_RNA|TXNDC6_uc010huf.1_Missense_Mutation_p.C75F|TXNDC6_uc003ese.1_Missense_Mutation_p.C99F	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	160	NDK.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						GGCCAAGGTACAGGTCCTCTC	0.453													35	69					4.00102e-26	5.77306e-26	1	0	A	138025304	A	A	138025304	3	1	176	1	0	0	0	0	1	0	0	0	16868	478	17	4	515	4	TXNDC6	3	138025304	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	8735327	138025304	59997126	109	32955											
CLSTN2	64084	broad.mit.edu	37	chr3	140122626	140122626	+	Frame_Shift_Del	DEL	G	-	-																															tcatccaggcctatgactgtGgtgctgggccccacgagaca																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:140122626delG	uc003etn.2	+	3	578	c.388delG	c.(388-390)GGTfs	p.G130fs	CLSTN2_uc003etm.2_Frame_Shift_Del_p.G130fs	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	130	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CTATGACTGTGGTGCTGGGCC	0.587										HNSCC(16;0.037)			---	---	---								-	140122626	-	-	140122626	7	5	176	1	0	1	0	1	0	0	0	0	3577	1348	47	0	398	0	CLSTN2	3	140122626	Frame_Shift_Del	DEL	G	TCGA-CV-5441-01A-01D-1512-08	2097322	140122626	57899804	110	32956											
ZIC1	7545	broad.mit.edu	37	chr3	147127954	147127954	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggcgtgaccacctttggcGcgtcccgccaccactccgcg	4	7	11	19	7	0	1	0	1	0	0	3	1	2	1	6	2	0	0	6	2	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:147127954G>A	uc003ewe.2	+	1	774	c.55G>A	c.(55-57)GCG>ACG	p.A19T		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	19					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A19A(1)		ovary(1)|central_nervous_system(1)	2						CACCTTTGGCGCGTCCCGCCA	0.741													15	32					0	0	0	0	A	147127954	A	A	147127954	3	1	176	1	0	0	0	0	1	0	0	0	17745	1087	38	1	57	1	ZIC1	3	147127954	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	7005328	147127954	50894476	111	32957											
SLITRK3	22865	broad.mit.edu	37	chr3	164907542	164907542	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggtctgataaggagcaatGggaggctggtttggaccagg	9	9	17	6	0	1	1	0	1	1	0	1	4	1	4	1	7	1	3	1	7	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:164907542G>C	uc003fej.3	-	2	1521	c.1077C>G	c.(1075-1077)CCC>CCG	p.P359P	SLITRK3_uc003fek.2_Silent_p.P359P	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	359	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						AAGGAGCAATGGGAGGCTGGT	0.502										HNSCC(40;0.11)			68	188					0	0	0	0	C	164907542	C	C	164907542	2	2	176	1	0	0	0	0	0	0	0	1	14808	1335	47	4		4	SLITRK3	3	164907542	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	17779588	164907542	33114888	112	32958											
SLC7A14	57709	broad.mit.edu	37	chr3	170216503	170216503	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctccgcccagtatttccCattgatgaagaagaggcctg	9	9	10	13	1	0	4	0	2	0	2	2	4	2	4	5	1	0	1	5	1	3	3	rs141548910		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:170216503C>A	uc003fgz.2	-	4	1028	c.712G>T	c.(712-714)GGG>TGG	p.G238W	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	238						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CAGTATTTCCCATTGATGAAG	0.522													31	76					2.48696e-23	3.52943e-23	1	0	A	170216503	A	A	170216503	3	1	176	1	0	0	0	0	1	0	0	0	14760	594	21	4	1623	4	SLC7A14	3	170216503	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	5308961	170216503	27805927	113	32959											
SPATA16	83893	broad.mit.edu	37	chr3	172835328	172835329	+	Frame_Shift_Ins	INS	-	T	T																															ttctttgatgccctttgtcaINStttttgttctttcaagtgtg																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:172835328_172835329insT	uc003fin.3	-	2	351_352	c.193_194insA	c.(193-195)ATGfs	p.M65fs		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	65					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GCCCTTTGTCATTTTTGTTCTT	0.401													---	---	---								T	172835329	T	T	172835328	7	5	176	1	0	1	1	0	0	0	0	0	15067	217	8	0	1555	0	SPATA16	3	172835328	Frame_Shift_Ins	INS	-	TCGA-CV-5441-01A-01D-1512-08	2618825	172835328	25187102	114	32960											
NLGN1	22871	broad.mit.edu	37	chr3	173997336	173997336	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttccctatgtactgggaatCcccatgattggccctacaga	9	11	9	12	0	0	2	0	1	0	1	2	3	2	3	4	2	2	2	4	2	4	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:173997336C>A	uc003fio.1	+	6	1968	c.1545C>A	c.(1543-1545)ATC>ATA	p.I515I	NLGN1_uc010hww.1_Silent_p.I555I|NLGN1_uc003fip.1_Silent_p.I515I	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	532	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TACTGGGAATCCCCATGATTG	0.443													27	55					5.61819e-17	7.25741e-17	1	0	A	173997336	A	A	173997336	2	1	176	1	0	0	0	0	0	0	0	1	10515	845	30	2		2	NLGN1	3	173997336	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1162008	173997336	24025094	115	32961											
CLCN2	1181	broad.mit.edu	37	chr3	184076565	184076565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatccaatcttcaccaaccCtggatactaggaacttgtgg	12	10	8	11	0	2	1	1	0	1	1	3	3	3	3	3	3	3	0	3	3	5	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:184076565C>T	uc003foi.2	-	3	381	c.257G>A	c.(256-258)AGG>AAG	p.R86K	CLCN2_uc003foh.2_5'Flank|CLCN2_uc010hya.1_Missense_Mutation_p.R86K|CLCN2_uc011brl.1_Missense_Mutation_p.R86K|CLCN2_uc011brm.1_Intron|CLCN2_uc011brn.1_Missense_Mutation_p.R86K|POLR2H_uc003foj.1_5'Flank	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	86	Cytoplasmic (By similarity).					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	TTCACCAACCCTGGATACTAG	0.557													3	15					0	0	0	0	T	184076565	T	T	184076565	3	4	176	1	0	0	0	0	1	0	0	0	3478	681	24	4	2527	4	CLCN2	3	184076565	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	10079229	184076565	13945865	116	32962											
EPHB3	2049	broad.mit.edu	37	chr3	184294701	184294701	+	Frame_Shift_Del	DEL	C	-	-																															tgatcctcgagtggagtgagCcccgggacctgggtggccgg																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:184294701delC	uc003foz.2	+	5	1521	c.1084delC	c.(1084-1086)CCCfs	p.P362fs		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	362	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.P362P(1)		lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GTGGAGTGAGCCCCGGGACCT	0.577													---	---	---								-	184294701	-	-	184294701	7	5	176	1	0	1	0	1	0	0	0	0	5200	739	26	0	1102	0	EPHB3	3	184294701	Frame_Shift_Del	DEL	C	TCGA-CV-5441-01A-01D-1512-08	218136	184294701	13727729	117	32963											
MAGEF1	64110	broad.mit.edu	37	chr3	184430794	184430797	+	5'Flank	DEL	TTCT	-	-																															ttcctgccttccttccttccTtctttccttccttccttcct																								rs9683253	by1000genomes	TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:184430794_184430797delTTCT	uc003fpa.2	-							NM_022149	NP_071432	Q9HAY2	MAGF1_HUMAN	melanoma antigen family F, 1											ovary(1)	1	all_cancers(143;4.61e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;5.64e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.56e-22)			ccttccttccttctttccttcctt	0													---	---	---								-	184430797	-	-	184430794	6	5	176	0	1	1	0	1	0	0	0	0	9240	1624	56	0		0	MAGEF1	3	184430794	5'Flank	DEL	TTCT	TCGA-CV-5441-01A-01D-1512-08	136093	184430794	13591636	118	32964											
C3orf21	152002	broad.mit.edu	37	chr3	194947466	194947466	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatctgatgcatggcgacCgagaggaagaagatggagtc	13	7	15	6	2	1	5	0	2	1	3	2	9	1	7	1	3	1	1	1	3	2	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:194947466C>T	uc003fum.3	-	2	732	c.624G>A	c.(622-624)TCG>TCA	p.S208S	C3orf21_uc011bsw.1_Silent_p.S62S	NM_152531	NP_689744	Q8NBI6	CC021_HUMAN	hypothetical protein LOC152002	208						integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)		GCATGGCGACCGAGAGGAAGA	0.537													6	90					0	0	0	0	T	194947466	T	T	194947466	2	4	176	1	0	0	0	0	0	0	0	1	2224	639	23	1		1	C3orf21	3	194947466	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	10516672	194947466	3074964	119	32965											
PAK2	5062	broad.mit.edu	37	chr3	196541368	196541368	+	Frame_Shift_Del	DEL	G	-	-																															tggtcatggaataccttgctGgggggtcactcactgatgtg																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr3:196541368delG	uc003fwy.3	+	11	1304	c.982delG	c.(982-984)GGGfs	p.G328fs		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	328	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		ATACCTTGCTGGGGGGTCACT	0.408													---	---	---								-	196541368	-	-	196541368	7	5	176	1	0	1	0	1	0	0	0	0	11455	1348	47	0	1020	0	PAK2	3	196541368	Frame_Shift_Del	DEL	G	TCGA-CV-5441-01A-01D-1512-08	1593902	196541368	1481062	120	32966											
POLN	353497	broad.mit.edu	37	chr4	2175683	2175683	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atctggaataataacttaccCcaagaagtgctgacgtcttc	13	11	7	10	1	2	2	0	1	2	1	3	3	2	3	2	1	3	1	2	1	6	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr4:2175683C>G	uc003ger.2	-	9	1373	c.1373G>C	c.(1372-1374)GGG>GCG	p.G458A	POLN_uc010ich.1_Missense_Mutation_p.G49A|POLN_uc011bvi.1_Missense_Mutation_p.G458A	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	458					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			ATAACTTACCCCAAGAAGTGC	0.438								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					130	105					0	0	0	0	G	2175683	G	G	2175683	3	3	176	1	0	0	0	0	1	0	0	0	12262	637	22	4	1393	4	POLN	4	2175683	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08		2175683	188978593	121	32967											
GRXCR1	389207	broad.mit.edu	37	chr4	43022369	43022369	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccctactctctctcgttaatAgggtgctgagaaaattttgt	9	15	8	9	1	2	1	0	1	2	1	4	2	2	1	1	1	2	2	1	1	5	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr4:43022369A>T	uc003gwt.2	+	3	628	c.628_splice	c.e3-2	p.G210_splice		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1						cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						TCTCGTTAATAGGGTGCTGAG	0.343													38	22					0	0	0	0	T	43022369	T	T	43022369	5	4	176	1	0	0	0	0	0	0	1	0	6851	434	15	5	636	5	GRXCR1	4	43022369	Splice_Site	SNP	A	TCGA-CV-5441-01A-01D-1512-08	40846686	43022369	148131907	122	32968											
GABRA2	2555	broad.mit.edu	37	chr4	46252598	46252598	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcataagcgttgttctgtatCataacggaagccttttcttt	9	16	8	8	2	3	0	1	0	2	0	3	1	3	1	1	1	3	4	1	1	4	8			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr4:46252598C>T	uc003gxc.3	-	9	1756	c.1083G>A	c.(1081-1083)ATG>ATA	p.M361I	GABRA2_uc010igc.2_Missense_Mutation_p.M361I|GABRA2_uc011bzc.1_Missense_Mutation_p.M366I	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	361	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGTTCTGTATCATAACGGAAG	0.398													8	105					0	0	0	0	T	46252598	T	T	46252598	3	4	176	1	0	0	0	0	1	0	0	0	6195	826	29	2	276	2	GABRA2	4	46252598	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	3230229	46252598	144901678	123	32969											
LPHN3	23284	broad.mit.edu	37	chr4	62813846	62813846	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaaaatttcaaccctaactGttcattttggagctactcca	12	13	6	10	0	2	0	2	0	0	0	3	2	3	2	2	2	4	2	2	2	5	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr4:62813846G>A	uc010ihh.2	+	14	2626	c.2453G>A	c.(2452-2454)TGT>TAT	p.C818Y	LPHN3_uc003hcq.3_Missense_Mutation_p.C818Y|LPHN3_uc003hct.2_Missense_Mutation_p.C211Y	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	805	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AACCCTAACTGTTCATTTTGG	0.378													35	21					0	0	0	0	A	62813846	A	A	62813846	3	1	176	1	0	0	0	0	1	0	0	0	8967	1377	48	4	2507	4	LPHN3	4	62813846	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	16561248	62813846	128340430	124	32970											
LPHN3	23284	broad.mit.edu	37	chr4	62845283	62845283	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcattgtgtttccagcaCagtgatgcggtccatgacct	7	15	9	10	1	1	2	1	2	0	0	3	2	3	2	3	1	2	2	3	1	0	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr4:62845283C>A	uc010ihh.2	+	15	2777	c.2604C>A	c.(2602-2604)CAC>CAA	p.H868Q	LPHN3_uc003hcq.3_Missense_Mutation_p.H868Q|LPHN3_uc003hct.2_Missense_Mutation_p.H261Q	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	855	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GTTTCCAGCACAGTGATGCGG	0.413													146	86					7.32983e-86	1.18652e-85	1	0	A	62845283	A	A	62845283	3	1	176	1	0	0	0	0	1	0	0	0	8967	477	17	4	2662	4	LPHN3	4	62845283	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	31437	62845283	128308993	125	32971											
PPM1K	152926	broad.mit.edu	37	chr4	89199527	89199527	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagaattggctcatcaatgCggttatcccagatcccaaaa	13	9	8	11	1	2	2	2	0	0	2	4	2	4	2	2	2	1	3	2	2	5	2	rs146041562		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr4:89199527C>T	uc003hrm.3	-	2	599	c.209G>A	c.(208-210)CGC>CAC	p.R70H	PPM1K_uc010ikp.1_Missense_Mutation_p.R70H|PPM1K_uc003hrn.2_Missense_Mutation_p.R70H	NM_152542	NP_689755	Q8N3J5	PPM1K_HUMAN	protein phosphatase 1K (PP2C domain containing)	70					protein dephosphorylation	mitochondrial matrix|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000192)		CTCATCAATGCGGTTATCCCA	0.512													30	25					0	0	0	0	T	89199527	T	T	89199527	3	4	176	1	0	0	0	0	1	0	0	0	12403	768	27	1	933	1	PPM1K	4	89199527	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	26354244	89199527	101954749	126	32972											
FAM190A	401145	broad.mit.edu	37	chr4	91549260	91549260	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgcccaacagtccatctgcGgattggcctctacaaggtgt	9	10	10	12	1	2	0	0	0	2	0	3	1	3	1	3	3	4	0	3	3	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr4:91549260G>T	uc003hsv.3	+	6	2149	c.1809G>T	c.(1807-1809)GCG>GCT	p.A603A	FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Silent_p.A603A	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	603										large_intestine(1)|ovary(1)	2						GTCCATCTGCGGATTGGCCTC	0.443													57	39					1.53582e-20	2.11023e-20	1	0	T	91549260	T	T	91549260	2	4	176	1	0	0	0	0	0	0	0	1	5549	1103	39	3		3	FAM190A	4	91549260	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2349733	91549260	99605016	127	32973											
CTSO	1519	broad.mit.edu	37	chr4	156860668	156860668	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attccactgcccccaccacgCtgaaggcccagcatcctcca	9	6	6	20	1	0	1	0	1	0	0	3	1	3	1	7	1	2	2	7	1	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr4:156860668C>G	uc003ipg.2	-	4	456	c.407G>C	c.(406-408)AGC>ACC	p.S136T		NM_001334	NP_001325	P43234	CATO_HUMAN	cathepsin O preproprotein	136					proteolysis	lysosome	cysteine-type endopeptidase activity				0	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		CCCCACCACGCTGAAGGCCCA	0.438													88	67					0	0	0	0	G	156860668	G	G	156860668	3	3	176	1	0	0	0	0	1	0	0	0	4057	797	28	4	578	4	CTSO	4	156860668	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	65311408	156860668	34293608	128	32974											
FSTL5	56884	broad.mit.edu	37	chr4	162841665	162841665	+	Silent	SNP	C	A	A																															aattctccgtcagatccacaCacaggtttgtagtgacgttt																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr4:162841665C>A	uc003iqh.2	-	4	736	c.300G>T	c.(298-300)GTG>GTT	p.V100V	FSTL5_uc003iqi.2_Silent_p.V99V|FSTL5_uc010iqv.2_Silent_p.V99V	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	100	Kazal-like.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CAGATCCACACACAGGTTTGT	0.443													48	31					2.01872e-29	2.94562e-29	1	0	A	162841665	A	A	162841665	2	1	176	1	0	0	0	0	0	0	0	1	6114	465	17	4		4	FSTL5	4	162841665	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	5980997	162841665	28312611	129	32975	67	2									
FSTL5	56884	broad.mit.edu	37	chr4	162841675	162841675	+	Missense_Mutation	SNP	T	C	C																															cagatccacacacaggtttgTagtgacgtttgcaaaggtcc																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr4:162841675T>C	uc003iqh.2	-	4	726	c.290A>G	c.(289-291)TAC>TGC	p.Y97C	FSTL5_uc003iqi.2_Missense_Mutation_p.Y96C|FSTL5_uc010iqv.2_Missense_Mutation_p.Y96C	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	97	Kazal-like.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CACAGGTTTGTAGTGACGTTT	0.433													49	30					0	0	0	0	C	162841675	C	C	162841675	3	2	176	1	0	0	0	0	1	0	0	0	6114	1638	57	5	2305	5	FSTL5	4	162841675	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	10	162841675	28312601	130	32976	67	2									
ADCY2	108	broad.mit.edu	37	chr5	7706876	7706876	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaagtgagggatgctactGgagttgatatcaacatgcgc	12	9	14	6	1	1	2	1	2	0	0	1	5	1	5	0	3	4	2	0	3	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:7706876G>A	uc003jdz.1	+	8	1196	c.1129G>A	c.(1129-1131)GGA>AGA	p.G377R	ADCY2_uc011cmo.1_Missense_Mutation_p.G197R	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	377	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGATGCTACTGGAGTTGATAT	0.443													54	131					0	0	0	0	A	7706876	A	A	7706876	3	1	176	1	0	0	0	0	1	0	0	0	294	1349	47	4	1159	4	ADCY2	5	7706876	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08		7706876	173208384	131	32977											
ADCY2	108	broad.mit.edu	37	chr5	7757586	7757586	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcaaaaaagcctctcccCtgctcatgtggcttttgaag	10	10	9	12	0	2	1	1	1	1	0	3	1	2	1	3	1	3	4	3	1	4	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:7757586C>G	uc003jdz.1	+	16	2048	c.1981C>G	c.(1981-1983)CTG>GTG	p.L661V	ADCY2_uc011cmo.1_Missense_Mutation_p.L481V	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	661					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AGCCTCTCCCCTGCTCATGTG	0.473													57	184					0	0	0	0	G	7757586	G	G	7757586	3	3	176	1	0	0	0	0	1	0	0	0	294	680	24	4	2043	4	ADCY2	5	7757586	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	50710	7757586	173157674	132	32978											
DNAH5	1767	broad.mit.edu	37	chr5	13735314	13735314	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctttagggtaagcaacaagGtgaacaggaatttgtgctcc	12	11	11	7	0	1	1	0	1	1	0	2	2	2	2	1	3	4	3	1	3	6	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:13735314G>A	uc003jfd.2	-	68	11729	c.11687C>T	c.(11686-11688)ACC>ATC	p.T3896I	DNAH5_uc003jfc.2_Missense_Mutation_p.T64I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3896					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAGCAACAAGGTGAACAGGAA	0.418									Kartagener_syndrome				38	90					0	0	0	0	A	13735314	A	A	13735314	3	1	176	1	0	0	0	0	1	0	0	0	4626	1261	44	4	2235	4	DNAH5	5	13735314	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	5977728	13735314	167179946	133	32979											
DNAH5	1767	broad.mit.edu	37	chr5	13865914	13865914	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagaagatttagttgcttCtttatttcaagaagctgagg	11	16	10	4	0	2	4	1	1	1	3	2	4	2	4	0	1	2	4	0	1	6	8			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:13865914C>A	uc003jfd.2	-	27	4260	c.4218G>T	c.(4216-4218)AAG>AAT	p.K1406N		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1406	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTAGTTGCTTCTTTATTTCAA	0.343									Kartagener_syndrome				40	75					1.96642e-18	2.59848e-18	1	0	A	13865914	A	A	13865914	3	1	176	1	0	0	0	0	1	0	0	0	4626	912	32	2	9868	2	DNAH5	5	13865914	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	130600	13865914	167049346	134	32980											
MARCH11	441061	broad.mit.edu	37	chr5	16067854	16067854	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcaaattcacagctcgcCagcgcttaaacactctgtaa	13	9	7	12	2	2	0	1	0	1	0	3	0	2	0	1	0	4	4	1	0	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:16067854C>A	uc003jfo.2	-	4	1148	c.935G>T	c.(934-936)TGG>TTG	p.W312L	MARCH11_uc010itw.1_Missense_Mutation_p.W68L	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	312						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						CACAGCTCGCCAGCGCTTAAA	0.428													21	40					2.39187e-15	3.02193e-15	1	0	A	16067854	A	A	16067854	3	1	176	1	0	0	0	0	1	0	0	0	9353	595	21	4	277	4	MARCH11	5	16067854	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2201940	16067854	164847406	135	32981											
DAB2	1601	broad.mit.edu	37	chr5	39377090	39377090	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtggacacagcaggagctGgaaaaatattgctctgaaaa	16	7	12	6	0	1	1	0	1	1	0	1	5	1	4	0	3	3	3	0	3	5	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:39377090G>A	uc003jlx.2	-	12	2330	c.1799C>T	c.(1798-1800)CCA>CTA	p.P600L	DAB2_uc003jlw.2_Missense_Mutation_p.P579L	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	600					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			AGCAGGAGCTGGAAAAATATT	0.572											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	48	147					0	0	0	0	A	39377090	A	A	39377090	3	1	176	1	0	0	0	0	1	0	0	0	4235	1348	47	4	525	4	DAB2	5	39377090	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	23309236	39377090	141538170	136	32982											
DAB2	1601	broad.mit.edu	37	chr5	39381569	39381569	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacctacctagacccaccagGggccccactggggcaggagc	9	3	12	17	0	0	1	0	0	0	1	0	2	0	2	6	5	2	1	6	5	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:39381569G>T	uc003jlx.2	-	11	2022	c.1491C>A	c.(1489-1491)CCC>CCA	p.P497P	DAB2_uc003jlw.2_Silent_p.P476P	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	497					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			GACCCACCAGGGGCCCCACTG	0.507													57	174					3.40165e-17	4.41618e-17	1	0	T	39381569	T	T	39381569	2	4	176	1	0	0	0	0	0	0	0	1	4235	1219	43	4		4	DAB2	5	39381569	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	4479	39381569	141533691	137	32983											
CARD6	84674	broad.mit.edu	37	chr5	40853333	40853333	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgccctccaggaagtgatGttctcttcttgcctcagatg	6	13	10	12	0	3	2	1	1	2	1	5	3	4	3	3	1	2	2	3	1	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:40853333G>A	uc003jmg.2	+	3	1974	c.1899G>A	c.(1897-1899)ATG>ATA	p.M633I		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	633					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						AGGAAGTGATGTTCTCTTCTT	0.522													11	278					0	0	0	0	A	40853333	A	A	40853333	3	1	176	1	0	0	0	0	1	0	0	0	2662	1377	48	4	1909	4	CARD6	5	40853333	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1471764	40853333	140061927	138	32984											
HEATR7B2	133558	broad.mit.edu	37	chr5	41004450	41004450	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaacaggctcacttacatCttcaaagaaggtccttgttt	12	13	6	10	0	3	1	2	0	1	1	4	1	4	1	1	2	2	2	1	2	5	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:41004450C>A	uc003jmj.3	-	37	4682	c.4192G>T	c.(4192-4194)GAT>TAT	p.D1398Y	HEATR7B2_uc003jmi.3_Missense_Mutation_p.D953Y	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1398	HEAT 15.						binding			ovary(6)|central_nervous_system(2)	8						TCACTTACATCTTCAAAGAAG	0.393													62	109					6.56249e-45	1.02391e-44	1	0	A	41004450	A	A	41004450	3	1	176	1	0	0	0	0	1	0	0	0	7074	913	32	2	589	2	HEATR7B2	5	41004450	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	151117	41004450	139910810	139	32985											
PLCXD3	345557	broad.mit.edu	37	chr5	41382389	41382389	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcattgactttggcactGaacaaaccatgagcaaaata	15	10	6	10	0	1	3	1	3	0	0	1	3	1	3	2	1	3	2	2	1	5	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:41382389G>T	uc003jmm.1	-	2	453	c.351C>A	c.(349-351)TTC>TTA	p.F117L		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	117	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						CTTTGGCACTGAACAAACCAT	0.448													57	116					3.89483e-19	5.25396e-19	1	0	T	41382389	T	T	41382389	3	4	176	1	0	0	0	0	1	0	0	0	12098	1281	45	2	622	2	PLCXD3	5	41382389	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	377939	41382389	139532871	140	32986											
IQGAP2	10788	broad.mit.edu	37	chr5	75936852	75936852	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctttcaagccacaagctcagGacccatccttagggaagagt	12	8	9	12	0	2	1	2	0	0	1	3	3	3	3	3	2	2	1	3	2	4	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:75936852G>T	uc003kek.2	+	17	2240	c.2018G>T	c.(2017-2019)GGA>GTA	p.G673V	IQGAP2_uc010izv.2_Missense_Mutation_p.G226V|IQGAP2_uc011csv.1_Intron|IQGAP2_uc003kel.2_Intron	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	673					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		ACAAGCTCAGGACCCATCCTT	0.423													26	52					1.17962e-10	1.39508e-10	1	0	T	75936852	T	T	75936852	3	4	176	1	0	0	0	0	1	0	0	0	7854	1174	41	2	2084	2	IQGAP2	5	75936852	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	34554463	75936852	104978408	141	32987											
PDE8B	8622	broad.mit.edu	37	chr5	76703252	76703252	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtccatggcgaggatccaCtccatgaccatcgaggctcc	8	7	10	16	3	0	1	0	1	0	0	5	4	4	2	6	3	0	1	6	3	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:76703252C>A	uc003kfa.2	+	13	1380	c.1335C>A	c.(1333-1335)CAC>CAA	p.H445Q	PDE8B_uc003kfb.2_Missense_Mutation_p.H425Q|PDE8B_uc003kfc.2_Missense_Mutation_p.H445Q|PDE8B_uc003kfd.2_Missense_Mutation_p.H398Q|PDE8B_uc003kfe.2_Missense_Mutation_p.H348Q	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	445					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		CGAGGATCCACTCCATGACCA	0.582													23	67					3.73988e-18	4.90445e-18	1	0	A	76703252	A	A	76703252	3	1	176	1	0	0	0	0	1	0	0	0	11708	564	20	4	1385	4	PDE8B	5	76703252	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	766400	76703252	104212008	142	32988											
NR2F1	7025	broad.mit.edu	37	chr5	92929334	92929334	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtcgcagtgcgcactggAggagtacgtgaggagccagt	10	6	17	8	3	0	1	0	1	0	0	1	5	0	4	1	3	3	3	1	3	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:92929334A>T	uc003kkj.2	+	3	2745	c.1058A>T	c.(1057-1059)GAG>GTG	p.E353V		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	353					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		TGCGCACTGGAGGAGTACGTG	0.647													23	77					0	0	0	0	T	92929334	T	T	92929334	3	4	176	1	0	0	0	0	1	0	0	0	10681	304	11	5	1068	5	NR2F1	5	92929334	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	16226082	92929334	87985926	143	32989											
EFNA5	1946	broad.mit.edu	37	chr5	106763036	106763037	+	Missense_Mutation	DNP	CC	AA	AA																															gagtgaggccggttacattcCcatctcttgaaccctttgga																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:106763036_106763037CC>AA	uc003kol.2	-	2	581_582	c.299_300GG>TT	c.(298-300)TGG>TTT	p.W100F	EFNA5_uc010jbr.1_Missense_Mutation_p.W100F	NM_001962	NP_001953	P52803	EFNA5_HUMAN	ephrin-A5 precursor	100					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding				0		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		GGTTACATTCCCATCTCTTGAA	0.495													28	81					0	0	0	0	AA	106763037	AA	AA	106763036	3	1	176	1	0	0	0	0	1	0	0	0	4976	624	22	4	402	4	EFNA5	5	106763036	Missense_Mutation	DNP	CC	TCGA-CV-5441-01A-01D-1512-08	13833702	106763036	74152224	144	32990											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139908268	139908268	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcataataacacaagccgtCtacctaaccagaacgggact	16	6	7	12	2	1	1	0	0	1	1	1	2	1	2	3	1	6	1	3	1	6	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:139908268C>T	uc003lfs.1	+	29	5861	c.5737C>T	c.(5737-5739)CTA>TTA	p.L1913L	ANKHD1_uc003lfr.2_Silent_p.L1913L|ANKHD1-EIF4EBP3_uc011czh.1_Silent_p.L652L|ANKHD1_uc003lfw.2_Silent_p.L551L|ANKHD1_uc010jfl.2_Silent_p.L348L|ANKHD1-EIF4EBP3_uc003lfx.1_Silent_p.L50L	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1913						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAAGCCGTCTACCTAACCA	0.488													28	48					0	0	0	0	T	139908268	T	T	139908268	2	4	176	1	0	0	0	0	0	0	0	1	629	912	32	2		2	ANKHD1-EIF4EBP3	5	139908268	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	33145232	139908268	41006992	145	32991											
PCDHB6	56130	broad.mit.edu	37	chr5	140530659	140530659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttagatgcaggatcgtttgGgaaggtatcttacgccctgt	8	14	12	7	2	1	1	0	0	1	1	2	3	1	3	1	3	2	3	1	3	4	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:140530659G>A	uc003lir.2	+	1	821	c.821G>A	c.(820-822)GGG>GAG	p.G274E	PCDHB6_uc011dah.1_Missense_Mutation_p.G138E	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	274	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGATCGTTTGGGAAGGTATCT	0.473													19	54					0	0	0	0	A	140530659	A	A	140530659	3	1	176	1	0	0	0	0	1	0	0	0	11600	1232	43	4	823	4	PCDHB6	5	140530659	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	622391	140530659	40384601	146	32992											
PCDHB9	56127	broad.mit.edu	37	chr5	140569126	140569126	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgagcggcaccgggaccctGttccagagctaccagtacga	9	6	13	13	3	0	2	0	1	0	1	1	4	1	3	4	2	4	4	4	2	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:140569126G>A	uc003liw.1	+	3	2235	c.2235G>A	c.(2233-2235)CTG>CTA	p.L745L	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	745	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGGACCCTGTTCCAGAGCT	0.647													109	99					0	0	0	0	A	140569126	A	A	140569126	2	1	176	1	0	0	0	0	0	0	0	1	11603	1377	48	4		4	PCDHB9	5	140569126	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	38467	140569126	40346134	147	32993											
PCDHB13	56123	broad.mit.edu	37	chr5	140595270	140595271	+	Missense_Mutation	DNP	GG	TT	TT																															ctggactacgaggccctgcaGgggttccagttccgcgtggg																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:140595270_140595271GG>TT	uc003lja.1	+	1	1762_1763	c.1575_1576GG>TT	c.(1573-1578)CAGGGG>CATTGG	p.525_526QG>HW		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	525_526	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGCCCTGCAGGGGTTCCAGTT	0.693													62	53					0	0	0	0	TT	140595271	TT	TT	140595270	3	4	176	1	0	0	0	0	1	0	0	0	11592	991	35	4	1577	4	PCDHB13	5	140595270	Missense_Mutation	DNP	GG	TCGA-CV-5441-01A-01D-1512-08	26144	140595270	40319990	148	32994											
PCDHGA7	56108	broad.mit.edu	37	chr5	140763189	140763189	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaatgaccacacgcctgtCttctctctgcctcagtacca	8	11	7	15	1	4	2	1	2	3	0	5	2	4	2	4	0	2	1	4	0	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:140763189C>T	uc003lka.1	+	1	723	c.723C>T	c.(721-723)GTC>GTT	p.V241V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Silent_p.V241V	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	241	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACGCCTGTCTTCTCTCTGC	0.587													11	27					0	0	0	0	T	140763189	T	T	140763189	2	4	176	1	0	0	0	0	0	0	0	1	11613	900	32	2		2	PCDHGA7	5	140763189	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	167919	140763189	40152071	149	32995											
PCDHGA11	56105	broad.mit.edu	37	chr5	140802351	140802351	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtgttctctatgccctacaAtccttcgactatgagcagtt	8	14	8	11	1	1	1	0	1	1	0	4	2	2	1	2	1	3	3	2	1	4	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:140802351A>T	uc003lkq.1	+	1	1815	c.1557A>T	c.(1555-1557)CAA>CAT	p.Q519H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.Q519H|PCDHGA11_uc003lkp.1_Missense_Mutation_p.Q519H	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	519	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCCCTACAATCCTTCGACT	0.542													43	126					0	0	0	0	T	140802351	T	T	140802351	3	4	176	1	0	0	0	0	1	0	0	0	11606	98	4	5	1559	5	PCDHGA11	5	140802351	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	39162	140802351	40112909	150	32996											
PCDHGC5	56097	broad.mit.edu	37	chr5	140868945	140868945	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gagccggggacgctggtgggGaatgttgctcaggatctggg	6	8	20	7	2	2	0	1	0	1	0	2	4	2	3	1	7	2	3	1	7	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:140868945G>C	uc003lla.1	+	1	138	c.138G>C	c.(136-138)GGG>GGC	p.G46G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc003lky.1_Intron|PCDHGC5_uc011dbc.1_Silent_p.G46G	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	46	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGGTGGGGAATGTTGCTC	0.572													16	65					0	0	0	0	C	140868945	C	C	140868945	2	2	176	1	0	0	0	0	0	0	0	1	11625	1161	41	2		2	PCDHGC5	5	140868945	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	66594	140868945	40046315	151	32997											
SH3TC2	79628	broad.mit.edu	37	chr5	148389880	148389880	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtggcgggtcccattgaagaAcacatcacctgcttcttcat	9	11	9	12	1	3	2	2	1	1	1	4	2	4	2	2	2	2	1	2	2	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:148389880A>T	uc003lpu.2	-	14	3432	c.3280T>A	c.(3280-3282)TTC>ATC	p.F1094I	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.F738I|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Missense_Mutation_p.F641I|SH3TC2_uc010jgx.2_Missense_Mutation_p.F1087I	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1094	TPR 5.						binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATTGAAGAACACATCACCT	0.537													29	33					0	0	0	0	T	148389880	T	T	148389880	3	4	176	1	0	0	0	0	1	0	0	0	14327	43	2	5	602	5	SH3TC2	5	148389880	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	7520935	148389880	32525380	152	32998											
MYOZ3	91977	broad.mit.edu	37	chr5	150056389	150056389	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagacccagcttcaacagAgtggcccagggctgggtccg	8	6	13	14	1	2	2	2	0	0	2	3	2	3	2	3	3	2	2	3	3	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:150056389A>T	uc003lss.2	+	7	1295	c.708A>T	c.(706-708)AGA>AGT	p.R236S	MYOZ3_uc003lsr.2_Missense_Mutation_p.R236S	NM_001122853	NP_001116325	Q8TDC0	MYOZ3_HUMAN	myozenin 3	236						sarcomere	protein binding			skin(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTTCAACAGAGTGGCCCAGG	0.637													35	81					0	0	0	0	T	150056389	T	T	150056389	3	4	176	1	0	0	0	0	1	0	0	0	10150	301	11	5	730	5	MYOZ3	5	150056389	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	1666509	150056389	30858871	153	32999											
FAT2	2196	broad.mit.edu	37	chr5	150920141	150920141	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctcacctgtgaacactgtGggctgttatcattgacgtcc	7	13	9	12	1	2	2	2	2	1	0	4	2	3	2	2	1	1	2	2	1	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:150920141G>C	uc003lue.3	-	10	9039	c.9026C>G	c.(9025-9027)CCA>CGA	p.P3009R	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3009	Extracellular (Potential).|Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAACACTGTGGGCTGTTATC	0.408													11	15					0	0	0	0	C	150920141	C	C	150920141	3	2	176	1	0	0	0	0	1	0	0	0	5722	1348	47	4	4079	4	FAT2	5	150920141	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	863752	150920141	29995119	154	33000											
KIF4B	285643	broad.mit.edu	37	chr5	154394078	154394078	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgccatctttacaatctccaTagagcaaagaaagaaaagtg	17	9	7	8	0	2	3	0	0	2	3	3	3	2	3	2	0	3	1	2	0	7	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:154394078T>C	uc010jih.1	+	1	819	c.659T>C	c.(658-660)ATA>ACA	p.I220T		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	220	Kinesin-motor.			I -> L (in Ref. 1; AF241316).	axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ACAATCTCCATAGAGCAAAGA	0.468													39	83					0	0	0	0	C	154394078	C	C	154394078	3	2	176	1	0	0	0	0	1	0	0	0	8343	1406	49	5	661	5	KIF4B	5	154394078	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	3473937	154394078	26521182	155	33001											
SLIT3	6586	broad.mit.edu	37	chr5	168244400	168244400	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaactggccaactgtccgtCgctgtcgcagccaatccgag	8	8	11	14	4	0	1	0	1	0	0	4	2	2	1	4	1	3	2	4	1	3	0	rs151091745		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:168244400C>A	uc003mab.2	-	8	1118	c.698G>T	c.(697-699)CGA>CTA	p.R233L	SLIT3_uc010jjg.2_Missense_Mutation_p.R233L|SLIT3_uc010jji.2_Missense_Mutation_p.R233L|SLIT3_uc003mac.1_Missense_Mutation_p.R30L	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	233	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AACTGTCCGTCGCTGTCGCAG	0.617													9	40					1.05317e-09	1.2287e-09	1	0	A	168244400	A	A	168244400	3	1	176	1	0	0	0	0	1	0	0	0	14805	884	31	3	3989	3	SLIT3	5	168244400	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	13850322	168244400	12670860	156	33002											
NSD1	64324	broad.mit.edu	37	chr5	176700778	176700779	+	Frame_Shift_Del	DEL	AT	-	-																															gaagccaccaccttataaacAtataaaggtgaggagaaaat																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr5:176700778_176700779delAT	uc003mfr.3	+	17	5753_5754	c.5615_5616delAT	c.(5614-5616)CATfs	p.H1872fs	NSD1_uc003mft.3_Frame_Shift_Del_p.H1603fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.H1769fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.H1520fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1872					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CCTTATAAACATATAAAGGTGA	0.45			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---								-	176700779	-	-	176700778	7	5	176	1	0	1	0	1	0	0	0	0	10723	217	8	0	5677	0	NSD1	5	176700778	Frame_Shift_Del	DEL	AT	TCGA-CV-5441-01A-01D-1512-08	8456378	176700778	4214482	157	33003											
HIST1H3J	8356	broad.mit.edu	37	chr6	27858380	27858380	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcgctgaaatggcagtttgCggatgagcagctcagtcgac	9	8	15	9	3	1	2	1	2	0	0	2	4	1	3	0	3	3	5	0	3	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:27858380C>T	uc003nka.2	-	1	191	c.191G>A	c.(190-192)CGC>CAC	p.R64H	HIST1H2BO_uc003nkc.1_5'Flank	NM_003535	NP_003526	P68431	H31_HUMAN	histone cluster 1, H3j	64					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						TGGCAGTTTGCGGATGAGCAG	0.607													6	96					0	0	0	0	T	27858380	T	T	27858380	3	4	176	1	0	0	0	0	1	0	0	0	7203	768	27	1	223	1	HIST1H3J	6	27858380	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08		27858380	143256687	158	33004											
OR2B6	26212	broad.mit.edu	37	chr6	27925796	27925796	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacagccgtctctgtgtacCtgcaaccaccttcgcccagc	7	9	8	17	2	1	0	0	0	1	0	3	0	1	0	5	0	6	3	5	0	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:27925796C>T	uc011dkx.1	+	1	778	c.778C>T	c.(778-780)CTG>TTG	p.L260L		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTCTGTGTACCTGCAACCACC	0.453													112	61					0	0	0	0	T	27925796	T	T	27925796	2	4	176	1	0	0	0	0	0	0	0	1	11045	680	24	4		4	OR2B6	6	27925796	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	67416	27925796	143189271	159	33005											
HLA-F	3134	broad.mit.edu	37	chr6	29691698	29691698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccgccgctacaaccagagcGaggctggtgagtgaacccgg	9	5	14	13	4	0	3	0	2	0	1	1	4	1	3	4	3	4	2	4	3	3	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:29691698G>A	uc010jrl.2	+	2	452	c.328G>A	c.(328-330)GAG>AAG	p.E110K	HLA-F_uc003nnm.3_Missense_Mutation_p.E110K|HLA-F_uc003nno.3_Missense_Mutation_p.E110K|HLA-F_uc011dlx.1_Missense_Mutation_p.E110K|HLA-F_uc011dly.1_RNA	NM_018950	NP_061823	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	110	Alpha-1.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						CAACCAGAGCGAGGCTGGTGA	0.677													8	0					0	0	0	0	A	29691698	A	A	29691698	3	1	176	1	0	0	0	0	1	0	0	0	7250	1059	37	1	334	1	HLA-F	6	29691698	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1765902	29691698	141423369	160	33006											
TAP2	6891	broad.mit.edu	37	chr6	32782378	32782378	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactgtcacctctggttgcActaggaagggaggaaaaatg	13	8	12	8	0	2	0	1	0	1	0	2	3	2	3	1	4	1	2	1	4	4	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:32782378A>T	uc011dqf.1	-	14	2305	c.2183T>A	c.(2182-2184)GTG>GAG	p.V728E	HLA-DOB_uc003oca.2_Missense_Mutation_p.V121E|HLA-DOB_uc011dqg.1_Missense_Mutation_p.V121E	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	Error:Variant_position_missing_in_Q03519_after_alignment					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						CTCTGGTTGCACTAGGAAGGG	0.493													117	74					0	0	0	0	T	32782378	T	T	32782378	3	4	176	1	0	0	0	0	1	0	0	0	15617	173	6	5		5	TAP2	6	32782378	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	3090680	32782378	138332689	161	33007											
WDR46	9277	broad.mit.edu	37	chr6	33254975	33254975	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatcttccccactgacacaTccaggtaggttagaaaccct	12	9	6	14	0	1	2	0	1	1	1	3	2	3	2	4	2	1	2	4	2	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:33254975T>C	uc003ods.2	-	9	952	c.908A>G	c.(907-909)GAT>GGT	p.D303G	WDR46_uc011dra.1_Missense_Mutation_p.D249G|WDR46_uc010juo.1_RNA|PFDN6_uc003odt.1_5'Flank|PFDN6_uc010jup.1_5'Flank	NM_005452	NP_005443	O15213	WDR46_HUMAN	WD repeat domain 46 isoform 1	303	WD 3.										0						CACTGACACATCCAGGTAGGT	0.517													120	61					0	0	0	0	C	33254975	C	C	33254975	3	2	176	1	0	0	0	0	1	0	0	0	17367	1435	50	5	952	5	WDR46	6	33254975	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	472597	33254975	137860092	162	33008											
MAPK13	5603	broad.mit.edu	37	chr6	36104684	36104684	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtctgtgggctgtatcatGgcagagatgctgacagggaa	9	10	16	6	0	2	2	1	1	1	1	2	4	2	3	0	4	1	4	0	4	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:36104684G>T	uc003ols.2	+	8	737	c.639G>T	c.(637-639)ATG>ATT	p.M213I	MAPK13_uc003olt.2_Intron	NM_002754	NP_002745	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	213	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3						GCTGTATCATGGCAGAGATGC	0.527													45	38					5.34276e-22	7.50013e-22	1	0	T	36104684	T	T	36104684	3	4	176	1	0	0	0	0	1	0	0	0	9328	1348	47	4	669	4	MAPK13	6	36104684	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2849709	36104684	135010383	163	33009											
DNAH8	1769	broad.mit.edu	37	chr6	38877379	38877379	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggttcagccgctggccaaGggaggctctgattgctgtgg	5	10	16	10	1	2	1	1	1	1	0	2	2	2	2	2	5	2	4	2	5	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:38877379G>T	uc003ooe.1	+	63	9548	c.8948G>T	c.(8947-8949)AGG>ATG	p.R2983M	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CGCTGGCCAAGGGAGGCTCTG	0.448													63	49					3.82636e-28	5.55198e-28	1	0	T	38877379	T	T	38877379	3	4	176	1	0	0	0	0	1	0	0	0	4629	1000	35	4	9190	4	DNAH8	6	38877379	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2772695	38877379	132237688	164	33010											
CDC5L	988	broad.mit.edu	37	chr6	44392275	44392275	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggaagaacgtgaaatagaTgatacttacattgaagatgc	16	10	10	5	1	0	6	0	3	0	3	0	7	0	7	0	1	4	0	0	1	7	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:44392275T>A	uc003oxl.2	+	11	1783	c.1524T>A	c.(1522-1524)GAT>GAA	p.D508E		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	508	Interaction with PPP1R8.|Interaction with DAPK3 (By similarity).				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GTGAAATAGATGATACTTACA	0.453													4	73					0	0	0	0	A	44392275	A	A	44392275	3	1	176	1	0	0	0	0	1	0	0	0	3097	1461	51	5	1566	5	CDC5L	6	44392275	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	5514896	44392275	126722792	165	33011											
RUNX2	860	broad.mit.edu	37	chr6	45405777	45405777	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttacagtagatggacctcGggaacccagaagtaagtact	14	8	11	8	1	0	2	0	0	0	2	1	4	0	4	2	2	3	4	2	2	6	4	rs104893991		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:45405777G>T	uc011dvx.1	+	5	884	c.674G>T	c.(673-675)CGG>CTG	p.R225L	RUNX2_uc011dvy.1_Missense_Mutation_p.R225L|RUNX2_uc003oxt.2_Missense_Mutation_p.R211L	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	225	Runt.		R -> W (in CLCD; interferes with nuclear localization; has severely impaired DNA binding and transactivation).|R -> L (in CLCD).|R -> Q (in CLCD; interferes with nuclear localization; abolishes DNA binding).		negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						GATGGACCTCGGGAACCCAGA	0.413													116	78					7.81258e-50	1.22634e-49	1	0	T	45405777	T	T	45405777	3	4	176	1	0	0	0	0	1	0	0	0	13813	1116	39	3	704	3	RUNX2	6	45405777	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1013502	45405777	125709290	166	33012											
FAM83B	222584	broad.mit.edu	37	chr6	54806055	54806055	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcttcaaagaaggaagttaaGggttccccaagttttttgaa	13	12	10	6	0	1	2	1	1	0	1	2	3	2	3	2	2	0	4	2	2	6	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:54806055G>A	uc003pck.2	+	5	2402	c.2286G>A	c.(2284-2286)AAG>AAA	p.K762K		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	762										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					AGGAAGTTAAGGGTTCCCCAA	0.378													34	102					0	0	0	0	A	54806055	A	A	54806055	2	1	176	1	0	0	0	0	0	0	0	1	5666	991	35	4		4	FAM83B	6	54806055	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	9400278	54806055	116309012	167	33013											
FILIP1	27145	broad.mit.edu	37	chr6	76124636	76124636	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgatggagggcttgggaCaggagatatgcccatcagat	11	8	15	7	1	1	3	1	1	0	2	1	7	1	5	1	4	1	1	1	4	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:76124636C>A	uc003pia.2	-	2	426	c.53G>T	c.(52-54)TGT>TTT	p.C18F	FILIP1_uc003phy.1_Missense_Mutation_p.C18F|FILIP1_uc010kbe.2_Missense_Mutation_p.C21F	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	18										skin(3)|ovary(1)	4						GGGCTTGGGACAGGAGATATG	0.423													62	78					1.08141e-31	1.59139e-31	1	0	A	76124636	A	A	76124636	3	1	176	1	0	0	0	0	1	0	0	0	5926	478	17	4	3608	4	FILIP1	6	76124636	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	21318581	76124636	94990431	168	33014											
PHIP	55023	broad.mit.edu	37	chr6	79770397	79770397	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttcatacttttatttgtgcGtagtaaagactgtcttccag	9	18	7	7	1	2	1	1	0	1	1	3	1	3	1	1	0	2	2	1	0	5	8			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:79770397G>T	uc003pir.2	-	5	554	c.328C>A	c.(328-330)CGC>AGC	p.R110S	PHIP_uc011dyp.1_Missense_Mutation_p.R110S	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	110					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TTATTTGTGCGTAGTAAAGAC	0.318													33	38					1.74807e-11	2.11565e-11	1	0	T	79770397	T	T	79770397	3	4	176	1	0	0	0	0	1	0	0	0	11897	1145	40	3	5281	3	PHIP	6	79770397	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3645761	79770397	91344670	169	33015											
CNR1	1268	broad.mit.edu	37	chr6	88854007	88854007	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgggcttggtctggccgggtCacctgtaccttcccatcctc	3	11	11	16	2	2	0	1	0	1	0	5	0	4	0	5	4	1	2	5	4	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:88854007C>T	uc011dzq.1	-	2	4550	c.987G>A	c.(985-987)GTG>GTA	p.V329V	CNR1_uc010kbz.2_Silent_p.V329V|CNR1_uc011dzr.1_Silent_p.V329V|CNR1_uc011dzs.1_Silent_p.V329V|CNR1_uc003pmq.3_Silent_p.V329V|CNR1_uc011dzt.1_Silent_p.V329V|CNR1_uc010kca.2_Silent_p.V296V	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	329	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	CTGGCCGGGTCACCTGTACCT	0.567													53	68					0	0	0	0	T	88854007	T	T	88854007	2	4	176	1	0	0	0	0	0	0	0	1	3646	813	29	2		2	CNR1	6	88854007	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	9083610	88854007	82261060	170	33016											
DCBLD1	285761	broad.mit.edu	37	chr6	117825024	117825024	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccaatcacactgtttgcgaAaagacaattacagtaccaaa	17	8	5	11	1	1	1	1	0	0	1	1	2	1	1	2	0	3	2	2	0	7	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:117825024A>G	uc003pxs.2	+	2	332	c.207A>G	c.(205-207)GAA>GAG	p.E69E	GOPC_uc003pxq.1_Intron|DCBLD1_uc003pxr.1_Silent_p.E69E	NM_173674	NP_775945	Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	69	CUB.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(1)	1		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		CTGTTTGCGAAAAGACAATTA	0.453													42	235					0	0	0	0	G	117825024	G	G	117825024	2	3	176	1	0	0	0	0	0	0	0	1	4297	11	1	5		5	DCBLD1	6	117825024	Silent	SNP	A	TCGA-CV-5441-01A-01D-1512-08	28971017	117825024	53290043	171	33017											
SLC35F1	222553	broad.mit.edu	37	chr6	118635271	118635271	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccacctccacctacatagcCcaggacccccgagtgtataa	11	7	6	17	1	0	0	0	0	0	0	2	2	2	1	7	1	2	1	7	1	4	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:118635271C>A	uc003pxx.3	+	8	1284	c.1083C>A	c.(1081-1083)GCC>GCA	p.A361A	SLC35F1_uc003pxy.1_Silent_p.A166A	NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	361					transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		CCTACATAGCCCAGGACCCCC	0.507													48	262					6.3008e-33	9.40581e-33	1	0	A	118635271	A	A	118635271	2	1	176	1	0	0	0	0	0	0	0	1	14652	610	22	4		4	SLC35F1	6	118635271	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	810247	118635271	52479796	172	33018											
HDDC2	51020	broad.mit.edu	37	chr6	125614026	125614026	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctttctgaggtcctctggTaggagctgggttatctgctt	4	16	12	9	0	3	1	0	1	3	0	5	2	5	2	2	4	2	4	2	4	2	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:125614026T>A	uc003qaa.1	-	4	543	c.339A>T	c.(337-339)CTA>CTT	p.L113L	HDDC2_uc003qab.1_RNA	NM_016063	NP_057147	Q7Z4H3	HDDC2_HUMAN	HD domain containing 2	113	HD.						metal ion binding|phosphoric diester hydrolase activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0186)		GGTCCTCTGGTAGGAGCTGGG	0.353													170	136					0	0	0	0	A	125614026	A	A	125614026	2	1	176	1	0	0	0	0	0	0	0	1	7055	1625	57	5		5	HDDC2	6	125614026	Silent	SNP	T	TCGA-CV-5441-01A-01D-1512-08	6978755	125614026	45501041	173	33019											
NCOA7	135112	broad.mit.edu	37	chr6	126210575	126210575	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaaataaacaattctgccGtggaaatgcaggtgcagtca	15	8	9	9	1	2	0	1	0	1	0	2	1	2	1	1	2	4	2	1	2	5	2	rs138843029		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:126210575G>T	uc010kes.2	+	11	1824	c.1375G>T	c.(1375-1377)GTG>TTG	p.V459L	NCOA7_uc003qae.3_Missense_Mutation_p.V459L|NCOA7_uc003qah.2_Missense_Mutation_p.V448L|NCOA7_uc003qai.2_Missense_Mutation_p.V459L|NCOA7_uc010ket.2_Missense_Mutation_p.V344L	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	459					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		CAATTCTGCCGTGGAAATGCA	0.453													41	162					1.7489e-18	2.31696e-18	1	0	T	126210575	T	T	126210575	3	4	176	1	0	0	0	0	1	0	0	0	10288	1145	40	3	1405	3	NCOA7	6	126210575	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	596549	126210575	44904492	174	33020											
SAMD3	154075	broad.mit.edu	37	chr6	130497054	130497054	+	Frame_Shift_Del	DEL	G	-	-																															tttccttgtctggcctcttcGgtgtccaaatttacacttat																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:130497054delG	uc003qbv.2	-	9	1080	c.754delC	c.(754-756)CGAfs	p.R252fs	SAMD3_uc003qbx.2_Frame_Shift_Del_p.R252fs|SAMD3_uc003qbw.2_Frame_Shift_Del_p.R252fs|SAMD3_uc010kfg.1_3'UTR	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	252										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TGGCCTCTTCGGTGTCCAAAT	0.348													---	---	---								-	130497054	-	-	130497054	7	5	176	1	0	1	0	1	0	0	0	0	13885	1124	39	0	828	0	SAMD3	6	130497054	Frame_Shift_Del	DEL	G	TCGA-CV-5441-01A-01D-1512-08	4286479	130497054	40618013	175	33021											
MED23	9439	broad.mit.edu	37	chr6	131946091	131946091	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggactatgctgaccatgaatAaacttaacaatccactggat	15	10	7	9	0	0	2	0	2	0	0	1	4	1	4	2	2	3	1	2	2	6	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:131946091A>G	uc003qcs.1	-	4	372	c.198T>C	c.(196-198)TTT>TTC	p.F66F	MED23_uc003qcq.2_Silent_p.F66F|MED23_uc003qct.1_Silent_p.F66F|MED23_uc011ecb.1_RNA	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	66					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		GACCATGAATAAACTTAACAA	0.378													39	190					0	0	0	0	G	131946091	G	G	131946091	2	3	176	1	0	0	0	0	0	0	0	1	9494	359	13	5		5	MED23	6	131946091	Silent	SNP	A	TCGA-CV-5441-01A-01D-1512-08	1449037	131946091	39168976	176	33022											
UTRN	7402	broad.mit.edu	37	chr6	144779941	144779941	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagaaataaaaaatgttctgGagaaggtttcatcagaatgg	18	10	10	3	0	3	3	2	0	1	3	3	4	3	3	0	3	0	2	0	3	7	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:144779941G>T	uc003qkt.2	+	19	2412	c.2320G>T	c.(2320-2322)GAG>TAG	p.E774*	UTRN_uc010khq.1_Nonsense_Mutation_p.E774*	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	774	Interaction with SYNM.|Spectrin 5.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AAATGTTCTGGAGAAGGTTTC	0.328													123	110					1.00425e-38	1.53906e-38	1	0	T	144779941	T	T	144779941	4	4	176	1	0	0	0	0	0	1	0	0	17171	1175	41	2	2394	2	UTRN	6	144779941	Nonsense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	12833850	144779941	26335126	177	33023											
SYNE1	23345	broad.mit.edu	37	chr6	152469434	152469434	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgtctgcagagcggtcgTgccagtgcaggtccgacaga	7	7	16	11	3	1	2	0	0	1	2	3	3	2	2	2	3	4	3	2	3	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:152469434T>A	uc010kiw.2	-	137	25324	c.24722A>T	c.(24721-24723)CAC>CTC	p.H8241L	SYNE1_uc010kiv.2_Missense_Mutation_p.H2765L|SYNE1_uc003qos.3_Missense_Mutation_p.H2765L|SYNE1_uc003qot.3_Missense_Mutation_p.H8170L|SYNE1_uc003qou.3_Missense_Mutation_p.H8241L|SYNE1_uc003qop.3_Missense_Mutation_p.H403L|SYNE1_uc011eez.1_Missense_Mutation_p.H443L|SYNE1_uc003qoq.3_Missense_Mutation_p.H443L|SYNE1_uc003qor.3_Missense_Mutation_p.H1141L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8241	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGAGCGGTCGTGCCAGTGCAG	0.617										HNSCC(10;0.0054)			32	75					0	0	0	0	A	152469434	A	A	152469434	3	1	176	1	0	0	0	0	1	0	0	0	15511	1696	59	5	1784	5	SYNE1	6	152469434	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	7689493	152469434	18645633	178	33024											
SYNE1	23345	broad.mit.edu	37	chr6	152623106	152623106	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcggtcaccgtcagcagcatGgtggcgtgcttggctttcat	5	12	13	11	3	3	0	3	0	0	0	4	0	3	0	1	4	3	4	1	4	0	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:152623106G>A	uc010kiw.2	-	92	18041	c.17439C>T	c.(17437-17439)ACC>ACT	p.T5813T	SYNE1_uc010kiv.2_Silent_p.T337T|SYNE1_uc003qos.3_Silent_p.T337T|SYNE1_uc003qot.3_Silent_p.T5742T|SYNE1_uc003qou.3_Silent_p.T5813T|SYNE1_uc010kiy.1_Silent_p.T35T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5813	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCAGCAGCATGGTGGCGTGCT	0.597										HNSCC(10;0.0054)			28	110					0	0	0	0	A	152623106	A	A	152623106	2	1	176	1	0	0	0	0	0	0	0	1	15511	1335	47	4		4	SYNE1	6	152623106	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	153672	152623106	18491961	179	33025											
SYNE1	23345	broad.mit.edu	37	chr6	152665308	152665308	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcctggcactgctgcaGggtgtcttgtcggctgacgt	4	10	15	12	2	1	1	0	1	1	0	2	1	1	1	2	4	2	4	2	4	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:152665308G>T	uc010kiw.2	-	74	12735	c.12133C>A	c.(12133-12135)CTG>ATG	p.L4045M	SYNE1_uc003qot.3_Missense_Mutation_p.L3974M|SYNE1_uc003qou.3_Missense_Mutation_p.L4045M|SYNE1_uc010kja.1_Missense_Mutation_p.L750M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4045	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CACTGCTGCAGGGTGTCTTGT	0.493										HNSCC(10;0.0054)			111	84					1.472e-32	2.19107e-32	1	0	T	152665308	T	T	152665308	3	4	176	1	0	0	0	0	1	0	0	0	15511	991	35	4	14625	4	SYNE1	6	152665308	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	42202	152665308	18449759	180	33026											
SYNE1	23345	broad.mit.edu	37	chr6	152673332	152673332	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcatgtgttctttccggaCagtgctggtcagttccttca	5	15	10	11	2	4	0	3	0	1	0	6	1	6	1	2	2	1	3	2	2	0	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:152673332C>G	uc010kiw.2	-	70	12012	c.11410G>C	c.(11410-11412)GTC>CTC	p.V3804L	SYNE1_uc003qot.3_Missense_Mutation_p.V3789L|SYNE1_uc003qou.3_Missense_Mutation_p.V3804L|SYNE1_uc010kja.1_Missense_Mutation_p.V509L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3804	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCTTTCCGGACAGTGCTGGTC	0.453										HNSCC(10;0.0054)			204	184					0	0	0	0	G	152673332	G	G	152673332	3	3	176	1	0	0	0	0	1	0	0	0	15511	478	17	4	15364	4	SYNE1	6	152673332	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	8024	152673332	18441735	181	33027											
SYNE1	23345	broad.mit.edu	37	chr6	152690250	152690250	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aggctcgtagcagtgtatttCctcaaggacagactgaaaag	13	9	11	8	1	1	2	1	1	0	1	3	3	2	3	1	2	1	4	1	2	5	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:152690250C>G	uc010kiw.2	-	61	10266	c.9664G>C	c.(9664-9666)GAA>CAA	p.E3222Q	SYNE1_uc003qot.3_Missense_Mutation_p.E3229Q|SYNE1_uc003qou.3_Missense_Mutation_p.E3222Q|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_Missense_Mutation_p.E300Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3222	Spectrin 6.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGTGTATTTCCTCAAGGACA	0.502										HNSCC(10;0.0054)			4	93					0	0	0	0	G	152690250	G	G	152690250	3	3	176	1	0	0	0	0	1	0	0	0	15511	864	30	2	17146	2	SYNE1	6	152690250	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	16918	152690250	18424817	182	33028											
SYNE1	23345	broad.mit.edu	37	chr6	152757237	152757237	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtccgtttagaaaactcCtagaaaaaatattatgatca	16	13	5	7	1	2	3	1	1	1	2	4	3	4	3	2	0	1	1	2	0	9	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:152757237C>A	uc010kiw.2	-	33	4752	c.4150_splice	c.e33-1	p.E1384_splice	SYNE1_uc003qot.3_Splice_Site_p.E1391_splice|SYNE1_uc003qou.3_Splice_Site_p.E1384_splice|SYNE1_uc010kjb.1_Splice_Site_p.E1367_splice|SYNE1_uc003qow.2_Splice_Site_p.E679_splice|SYNE1_uc003qox.1_Intron	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TAGAAAACTCCTAGAAAAAAT	0.398										HNSCC(10;0.0054)			88	65					1.67174e-50	2.63211e-50	1	0	A	152757237	A	A	152757237	5	1	176	1	0	0	0	0	0	0	1	0	15511	695	24	4	22773	4	SYNE1	6	152757237	Splice_Site	SNP	C	TCGA-CV-5441-01A-01D-1512-08	66987	152757237	18357830	183	33029											
ARID1B	57492	broad.mit.edu	37	chr6	157469762	157469762	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttgctttttgtttaggtaaCtactccagacccccagcgta	8	15	7	11	1	0	1	0	0	0	1	1	1	1	1	3	1	4	4	3	1	4	8			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:157469762C>G	uc003qqn.2	+	8	2495	c.2343C>G	c.(2341-2343)AAC>AAG	p.N781K	ARID1B_uc003qqo.2_Missense_Mutation_p.N794K|ARID1B_uc003qqp.2_Missense_Mutation_p.N781K|ARID1B_uc003qqq.1_Missense_Mutation_p.N223K|ARID1B_uc010kjl.2_5'UTR	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	839					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GTTTAGGTAACTACTCCAGAC	0.473													53	286					0	0	0	0	G	157469762	G	G	157469762	3	3	176	1	0	0	0	0	1	0	0	0	914	564	20	4	2590	4	ARID1B	6	157469762	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	4712525	157469762	13645305	184	33030											
ARID1B	57492	broad.mit.edu	37	chr6	157470017	157470018	+	Frame_Shift_Del	DEL	TG	-	-																															atggggccgccaatgccaacTgtgaaccgtaaggcacagga																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr6:157470017_157470018delTG	uc003qqn.2	+	8	2750_2751	c.2598_2599delTG	c.(2596-2601)ACTGTGfs	p.T866fs	ARID1B_uc003qqo.2_Frame_Shift_Del_p.T879fs|ARID1B_uc003qqp.2_Frame_Shift_Del_p.T866fs|ARID1B_uc003qqq.1_Frame_Shift_Del_p.T308fs|ARID1B_uc010kjl.2_Frame_Shift_Del_p.T64fs	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	924_925					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CAATGCCAACTGTGAACCGTAA	0.604													---	---	---								-	157470018	-	-	157470017	7	5	176	1	0	1	0	1	0	0	0	0	914	1567	55	0	2845	0	ARID1B	6	157470017	Frame_Shift_Del	DEL	TG	TCGA-CV-5441-01A-01D-1512-08	255	157470017	13645050	185	33031											
THSD7A	221981	broad.mit.edu	37	chr7	11675973	11675973	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttgcttgtcttacttgtCgggagtggggcattgagcag	5	14	14	8	1	1	1	0	1	1	0	3	2	2	2	1	3	3	3	1	3	1	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:11675973C>A	uc003ssf.3	-	2	1058	c.806G>T	c.(805-807)CGA>CTA	p.R269L		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	269	Extracellular (Potential).|Potential.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TCTTACTTGTCGGGAGTGGGG	0.557										HNSCC(18;0.044)			52	104					2.73381e-35	4.12861e-35	1	0	A	11675973	A	A	11675973	3	1	176	1	0	0	0	0	1	0	0	0	15945	884	31	3	4271	3	THSD7A	7	11675973	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08		11675973	147462690	186	33032											
ITGB8	3696	broad.mit.edu	37	chr7	20449331	20449331	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagtcctgatcattagacAggtgatactacaatggaata	16	11	8	6	0	1	3	1	2	0	1	2	4	2	4	1	2	2	0	1	2	8	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:20449331A>T	uc003suu.2	+	13	2822	c.2117A>T	c.(2116-2118)CAG>CTG	p.Q706L	ITGB8_uc011jyh.1_Missense_Mutation_p.Q571L	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	706	Cytoplasmic (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						ATCATTAGACAGGTGATACTA	0.338													57	127					0	0	0	0	T	20449331	T	T	20449331	3	4	176	1	0	0	0	0	1	0	0	0	7940	188	7	5	2167	5	ITGB8	7	20449331	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	8773358	20449331	138689332	187	33033											
KLHL7	55975	broad.mit.edu	37	chr7	23205333	23205333	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggattatagctggacagAcatccgctgcccctttgaaa	12	9	9	11	1	0	2	0	1	0	1	1	4	1	4	3	2	2	2	3	2	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:23205333A>G	uc003svs.3	+	8	1246	c.953A>G	c.(952-954)GAC>GGC	p.D318G	KLHL7_uc003svr.3_Missense_Mutation_p.D296G|KLHL7_uc011jys.1_Missense_Mutation_p.D242G|KLHL7_uc011jyt.1_Missense_Mutation_p.D93G|KLHL7_uc003svt.2_Missense_Mutation_p.D270G|KLHL7_uc011jyv.1_Missense_Mutation_p.D93G	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	318	Kelch 1.					Golgi apparatus|nucleolus|plasma membrane					0						AGCTGGACAGACATCCGCTGC	0.403													26	52					0	0	0	0	G	23205333	G	G	23205333	3	3	176	1	0	0	0	0	1	0	0	0	8433	275	10	5	1046	5	KLHL7	7	23205333	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	2756002	23205333	135933330	188	33034											
ANLN	54443	broad.mit.edu	37	chr7	36478884	36478884	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caagtgaattccagtgttgaAgaaagaggttttctagtaag	14	12	11	4	0	1	4	0	2	1	2	2	4	2	4	1	1	0	3	1	1	6	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:36478884A>T	uc003tff.2	+	21	3159	c.2955A>T	c.(2953-2955)GAA>GAT	p.E985D	ANLN_uc011kaz.1_Missense_Mutation_p.E897D|ANLN_uc003tfg.2_Missense_Mutation_p.E948D|ANLN_uc010kxe.2_Missense_Mutation_p.E947D	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	985	PH.|Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						CCAGTGTTGAAGAAAGAGGTT	0.308													16	28					0	0	0	0	T	36478884	T	T	36478884	3	4	176	1	0	0	0	0	1	0	0	0	694	69	3	5	3037	5	ANLN	7	36478884	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	13273551	36478884	122659779	189	33035											
AMPH	273	broad.mit.edu	37	chr7	38505100	38505100	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggatggtgaaggccttgtcgGcgtgctggtcacccagtttt	5	12	15	9	2	1	1	1	1	0	0	2	2	1	2	2	5	1	2	2	5	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:38505100G>C	uc003tgu.2	-	9	785	c.716C>G	c.(715-717)GCC>GGC	p.A239G	AMPH_uc003tgv.2_Missense_Mutation_p.A239G|AMPH_uc003tgt.2_5'Flank	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	239	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						GGCCTTGTCGGCGTGCTGGTC	0.507													7	5					0	0	0	0	C	38505100	C	C	38505100	3	2	176	1	0	0	0	0	1	0	0	0	588	1203	42	4	1423	4	AMPH	7	38505100	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2026216	38505100	120633563	190	33036											
HECW1	23072	broad.mit.edu	37	chr7	43400528	43400528	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tactaccatggagtgagtggGgccctgcgagcaaccacccc	9	6	12	14	1	0	1	0	1	0	0	0	3	0	2	5	3	5	1	5	3	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:43400528G>T	uc003tid.1	+	6	1109	c.504G>T	c.(502-504)GGG>GGT	p.G168G	HECW1_uc011kbi.1_Silent_p.G168G|HECW1_uc003tie.1_Silent_p.G200G	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	168					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GAGTGAGTGGGGCCCTGCGAG	0.478													28	91					5.45727e-16	6.96272e-16	1	0	T	43400528	T	T	43400528	2	4	176	1	0	0	0	0	0	0	0	1	7081	1219	43	4		4	HECW1	7	43400528	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	4895428	43400528	115738135	191	33037											
POM121L12	285877	broad.mit.edu	37	chr7	53103940	53103940	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccaagggaagcgctaggttCgacgggccgttgtggttcga	7	8	16	10	5	0	0	0	0	0	0	2	3	0	1	2	4	1	4	2	4	3	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:53103940C>T	uc003tpz.2	+	1	592	c.576C>T	c.(574-576)TTC>TTT	p.F192F		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	192											0						GCGCTAGGTTCGACGGGCCGT	0.587													25	63					0	0	0	0	T	53103940	T	T	53103940	2	4	176	1	0	0	0	0	0	0	0	1	12296	883	31	1		1	POM121L12	7	53103940	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	9703412	53103940	106034723	192	33038											
CACNA2D1	781	broad.mit.edu	37	chr7	81693671	81693671	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcagctccttggatgtacCtgaaacaaatattgtaataa	15	12	7	7	0	0	1	0	1	0	0	1	2	1	2	2	1	4	4	2	1	6	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:81693671C>G	uc003uhr.1	-	9	985	c.729_splice	c.e9-1	p.W243_splice		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha							voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TTGGATGTACCTGAAACAAAT	0.323													24	63					0	0	0	0	G	81693671	G	G	81693671	5	3	176	1	0	0	0	0	0	0	1	0	2560	695	24	4	2671	4	CACNA2D1	7	81693671	Splice_Site	SNP	C	TCGA-CV-5441-01A-01D-1512-08	28589731	81693671	77444992	193	33039											
DLX5	1749	broad.mit.edu	37	chr7	96650315	96650315	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggactgtgctccgggggCatctccccgtttttcatgat	4	13	12	12	2	2	1	1	1	1	0	4	2	3	2	3	3	1	3	3	3	0	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:96650315C>T	uc003uon.2	-	3	811	c.603G>A	c.(601-603)ATG>ATA	p.M201I		NM_005221	NP_005212	P56178	DLX5_HUMAN	distal-less homeobox 5	201					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GCTCCGGGGGCATCTCCCCGT	0.577													23	63					0	0	0	0	T	96650315	T	T	96650315	3	4	176	1	0	0	0	0	1	0	0	0	4596	710	25	4	270	4	DLX5	7	96650315	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	14956644	96650315	62488348	194	33040											
GIGYF1	64599	broad.mit.edu	37	chr7	100280797	100280797	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggagctgggtgcggggggCacagggaccgcctgctgctg	4	5	22	10	2	0	0	0	0	0	0	0	2	0	2	2	7	4	4	2	7	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:100280797C>G	uc003uwg.1	-	19	3259	c.2250G>C	c.(2248-2250)GTG>GTC	p.V750V		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	750										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GTGCGGGGGGCACAGGGACCG	0.677													8	18					0	0	0	0	G	100280797	G	G	100280797	2	3	176	1	0	0	0	0	0	0	0	1	6414	697	25	4		4	GIGYF1	7	100280797	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	3630482	100280797	58857866	195	33041											
ZAN	7455	broad.mit.edu	37	chr7	100377308	100377308	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgccaggctctgcaagcCttcggggccacctgccagag	6	7	12	16	1	2	1	0	0	2	1	3	1	2	1	5	3	4	2	5	3	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:100377308C>A	uc003uwj.2	+	36	6723	c.6558C>A	c.(6556-6558)GCC>GCA	p.A2186A	ZAN_uc003uwk.2_Silent_p.A2186A|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Intron	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2186	Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTCTGCAAGCCTTCGGGGCCA	0.642													3	8					0.004672	0.00484019	1	0	A	100377308	A	A	100377308	2	1	176	1	0	0	0	0	0	0	0	1	17581	668	24	4		4	ZAN	7	100377308	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	96511	100377308	58761355	196	33042											
RELN	5649	broad.mit.edu	37	chr7	103290782	103290782	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtctccagcgaatcctggtGttccgggttagtgctgcgtt	4	14	13	10	3	1	0	0	0	1	0	4	1	3	0	3	2	3	4	3	2	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:103290782G>T	uc003vca.2	-	16	2101	c.1941C>A	c.(1939-1941)AAC>AAA	p.N647K	RELN_uc010liz.2_Missense_Mutation_p.N647K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	647					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GAATCCTGGTGTTCCGGGTTA	0.423													23	80					3.28513e-13	4.04203e-13	1	0	T	103290782	T	T	103290782	3	4	176	1	0	0	0	0	1	0	0	0	13285	1368	48	4	8641	4	RELN	7	103290782	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2913474	103290782	55847881	197	33043											
CDHR3	222256	broad.mit.edu	37	chr7	105603804	105603804	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctggctctcctgggtgccAtgtcaggtaggaactcaatt	7	12	11	11	0	3	0	2	0	1	0	5	1	4	1	3	4	2	2	3	4	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:105603804A>G	uc003vdl.3	+	1	148	c.40A>G	c.(40-42)ATG>GTG	p.M14V	CDHR3_uc003vdk.2_Intron|CDHR3_uc011kls.1_RNA|CDHR3_uc003vdm.3_Missense_Mutation_p.M14V|CDHR3_uc011klt.1_5'UTR	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	14					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CCTGGGTGCCATGTCAGGTAG	0.488													85	163					0	0	0	0	G	105603804	G	G	105603804	3	3	176	1	0	0	0	0	1	0	0	0	3135	217	8	5	42	5	CDHR3	7	105603804	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	2313022	105603804	53534859	198	33044											
PIK3CG	5294	broad.mit.edu	37	chr7	106507993	106507993	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgtgtccctccgctcccAggtcgcatagggcatggagc	5	8	12	16	2	0	0	0	0	0	0	4	1	3	1	4	3	1	3	4	3	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:106507993A>T	uc003vdv.3	+	2	74	c.-11_splice	c.e2-2		PIK3CG_uc003vdu.2_Splice_Site|PIK3CG_uc003vdw.2_Splice_Site	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma						G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CTCCGCTCCCAGGTCGCATAG	0.567													37	101					0	0	0	0	T	106507993	T	T	106507993	5	4	176	1	0	0	0	0	0	0	1	0	11971	202	7	5		5	PIK3CG	7	106507993	Splice_Site	SNP	A	TCGA-CV-5441-01A-01D-1512-08	904189	106507993	52630670	199	33045											
PIK3CG	5294	broad.mit.edu	37	chr7	106509367	106509368	+	Nonsense_Mutation	DNP	CC	AA	AA																															agagtcccccagttctgagtCcaagggcaaagttcagcttc																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:106509367_106509368CC>AA	uc003vdv.3	+	2	1446_1447	c.1361_1362CC>AA	c.(1360-1362)TCC>TAA	p.S454*	PIK3CG_uc003vdu.2_Nonsense_Mutation_p.S454*|PIK3CG_uc003vdw.2_Nonsense_Mutation_p.S454*	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	454					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						AGTTCTGAGTCCAAGGGCAAAG	0.53													39	99					0	0	0	0	AA	106509368	AA	AA	106509367	4	1	176	1	0	0	0	0	0	1	0	0	11971	855	30	2	1363	2	PIK3CG	7	106509367	Nonsense_Mutation	DNP	CC	TCGA-CV-5441-01A-01D-1512-08	1374	106509367	52629296	200	33046											
ST7	7982	broad.mit.edu	37	chr7	116590682	116590683	+	5'Flank	INS	-	CCC	CCC																															tccttccttccttccttcctINStcctccctcctccctcctcc																								rs78594674		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:116590682_116590683insCCC	uc003vin.2	+						ST7_uc011knl.1_5'Flank|ST7_uc003vio.2_5'Flank	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b							integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		ccttccttccttcctccctcct	0.079													---	---	---								CCC	116590683	CCC	CCC	116590682	6	5	176	0	1	1	1	0	0	0	0	0	15295	1624	56	0		0	ST7	7	116590682	5'Flank	INS	-	TCGA-CV-5441-01A-01D-1512-08	10081315	116590682	42547981	201	33047											
SLC13A1	6561	broad.mit.edu	37	chr7	122787212	122787213	+	Splice_Site	DNP	CG	TA	TA																															caatccaataaggttacttaCgtattgaaatactctgcaaa																								rs150284958		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:122787212_122787213CG>TA	uc003vkm.2	-	7	837	c.812_splice	c.e7+1	p.T271_splice	SLC13A1_uc010lks.2_Splice_Site_p.T147_splice	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate							integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	AGGTTACTTACGTATTGAAATA	0.356													35	38					0	0	0	0	TA	122787213	TA	TA	122787212	5	4	176	1	0	0	0	0	0	0	1	0	14456	550	19	1	1010	1	SLC13A1	7	122787212	Splice_Site	DNP	CG	TCGA-CV-5441-01A-01D-1512-08	6196530	122787212	36351451	202	33048											
GPR37	2861	broad.mit.edu	37	chr7	124387211	124387211	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaccccaaatcctccttgcTcagctggcggagaacaactt	12	8	7	14	1	1	1	1	0	0	1	3	2	3	1	4	2	5	2	4	2	4	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:124387211T>A	uc003vli.2	-	2	1861	c.1210A>T	c.(1210-1212)AGC>TGC	p.S404C		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	404	Extracellular (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						TCCTCCTTGCTCAGCTGGCGG	0.473													44	104					0	0	0	0	A	124387211	A	A	124387211	3	1	176	1	0	0	0	0	1	0	0	0	6729	1551	54	5	635	5	GPR37	7	124387211	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	1599999	124387211	34751452	203	33049											
LRRC4	64101	broad.mit.edu	37	chr7	127670179	127670179	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccaagtccaggcgcatgaggGagggcacccggttgaaggcg	9	4	17	11	3	0	2	0	2	0	0	1	3	1	3	3	5	0	3	3	5	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:127670179G>A	uc003vmk.2	-	2	652	c.515C>T	c.(514-516)TCC>TTC	p.S172F	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	172	LRR 5.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GCGCATGAGGGAGGGCACCCG	0.567													56	117					0	0	0	0	A	127670179	A	A	127670179	3	1	176	1	0	0	0	0	1	0	0	0	9047	1174	41	2	1450	2	LRRC4	7	127670179	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3282968	127670179	31468484	204	33050											
MKLN1	4289	broad.mit.edu	37	chr7	131128284	131128284	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgatctacacttttggtggTagaattttgacttgtaatgg	10	17	10	4	0	1	3	0	2	1	1	1	3	1	3	0	3	1	2	0	3	4	8			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:131128284T>C	uc011kpm.1	+	11	1282	c.1218T>C	c.(1216-1218)GGT>GGC	p.G406G	MKLN1_uc011kpl.1_Silent_p.G383G|MKLN1_uc010lmh.2_Silent_p.G406G|MKLN1_uc003vqs.2_Silent_p.G199G	NM_013255	NP_037387	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing	406					signal transduction	cytoplasm	protein binding			breast(1)	1	Melanoma(18;0.162)					CTTTTGGTGGTAGAATTTTGA	0.393													5	119					0	0	0	0	C	131128284	C	C	131128284	2	2	176	1	0	0	0	0	0	0	0	1	9656	1625	57	5		5	MKLN1	7	131128284	Silent	SNP	T	TCGA-CV-5441-01A-01D-1512-08	3458105	131128284	28010379	205	33051											
MGAM	8972	broad.mit.edu	37	chr7	141719028	141719028	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaccaacgtggctgttgctgGaatccccagggagctgtaag	9	8	14	10	1	0	0	0	0	0	0	1	3	1	2	3	3	3	5	3	3	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:141719028G>A	uc003vwy.2	+	4	411	c.357G>A	c.(355-357)TGG>TGA	p.W119*		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	119	P-type 1.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GCTGTTGCTGGAATCCCCAGG	0.448													38	112					0	0	0	0	A	141719028	A	A	141719028	4	1	176	1	0	0	0	0	0	1	0	0	9594	1183	41	2	367	2	MGAM	7	141719028	Nonsense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	10590744	141719028	17419635	206	33052											
CLCN1	1180	broad.mit.edu	37	chr7	143028713	143028713	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcatgctcggtgtccgaaaGcacaaggccctcagccagtt	9	8	11	13	2	2	0	2	0	0	0	4	1	3	0	3	2	3	3	3	2	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:143028713G>A	uc003wcr.1	+	10	1221	c.1134G>A	c.(1132-1134)AAG>AAA	p.K378K	CLCN1_uc011ktc.1_Silent_p.K40K	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	378					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					GTGTCCGAAAGCACAAGGCCC	0.478													37	93					0	0	0	0	A	143028713	A	A	143028713	2	1	176	1	0	0	0	0	0	0	0	1	3477	962	34	4		4	CLCN1	7	143028713	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1309685	143028713	16109950	207	33053											
SSPO	23145	broad.mit.edu	37	chr7	149473575	149473575	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gccctggagtggccgctcggGgcttacccggtccccagcgc	3	6	15	17	4	0	0	0	0	0	0	2	1	1	1	5	5	2	2	5	5	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr7:149473575G>A	uc010lpk.2	+	2	191	c.191G>A	c.(190-192)GGG>GAG	p.G64E	SSPO_uc010lpl.1_5'UTR	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	64	EMI.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCCGCTCGGGGCTTACCCGG	0.662													4	6					0	0	0	0	A	149473575	A	A	149473575	3	1	176	1	0	0	0	0	1	0	0	0	15255	1232	43	4	197	4	SSPO	7	149473575	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	6444862	149473575	9665088	208	33054											
PTK2B	2185	broad.mit.edu	37	chr8	27311740	27311740	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaatgtcatggagctggtgCgggccgtgctggagctcaag	7	9	16	9	2	3	0	3	0	0	0	3	2	3	2	1	4	4	3	1	4	2	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:27311740C>T	uc003xfn.1	+	34	3473	c.2665C>T	c.(2665-2667)CGG>TGG	p.R889W	PTK2B_uc003xfo.1_Missense_Mutation_p.R889W|PTK2B_uc003xfp.1_Missense_Mutation_p.R889W|PTK2B_uc003xfq.1_Missense_Mutation_p.R847W	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	889	Focal adhesion targeting (FAT).|Interaction with TGFB1I1 (By similarity).				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		GGAGCTGGTGCGGGCCGTGCT	0.622													30	26					0	0	0	0	T	27311740	T	T	27311740	3	4	176	1	0	0	0	0	1	0	0	0	12826	759	27	1	2775	1	PTK2B	8	27311740	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08		27311740	119052282	209	33055											
PBK	55872	broad.mit.edu	37	chr8	27668593	27668593	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaataacaccattctcctcCacagcttctttgggtttcca	9	14	5	13	0	2	0	0	0	2	0	5	0	4	0	4	1	2	3	4	1	2	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:27668593C>T	uc003xgi.2	-	7	855	c.654G>A	c.(652-654)GTG>GTA	p.V218V	ESCO2_uc010luy.1_Intron|PBK_uc011lap.1_Silent_p.V229V	NM_018492	NP_060962	Q96KB5	TOPK_HUMAN	PDZ binding kinase	218	Protein kinase.				mitosis		ATP binding|protein binding|protein serine/threonine kinase activity				0		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|KIRC - Kidney renal clear cell carcinoma(542;0.101)|Kidney(114;0.121)|Colorectal(74;0.141)		CATTCTCCTCCACAGCTTCTT	0.413													26	30					0	0	0	0	T	27668593	T	T	27668593	2	4	176	1	0	0	0	0	0	0	0	1	11542	581	21	4		4	PBK	8	27668593	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	356853	27668593	118695429	210	33056											
C8orf34	116328	broad.mit.edu	37	chr8	69633639	69633639	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactaatggaggagggtgaCgaatttgagaaagcatctaa	15	8	13	5	1	1	2	0	2	1	1	1	6	1	4	0	3	1	2	0	3	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:69633639C>A	uc010lyz.2	+	10	1162	c.1113C>A	c.(1111-1113)GAC>GAA	p.D371E	C8orf34_uc003xyb.2_Missense_Mutation_p.D346E	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	371					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			AGGAGGGTGACGAATTTGAGA	0.279													31	36					8.16277e-20	1.11565e-19	1	0	A	69633639	A	A	69633639	3	1	176	1	0	0	0	0	1	0	0	0	2434	535	19	3	1072	3	C8orf34	8	69633639	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	41965046	69633639	76730383	211	33057											
XKR9	389668	broad.mit.edu	37	chr8	71646336	71646336	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aattcttatataggattgttGttggattcattcttatcttt	9	22	6	4	0	4	0	1	0	3	0	4	2	4	2	0	2	0	2	0	2	5	11			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:71646336G>T	uc003xyq.2	+	5	1333	c.799G>T	c.(799-801)GTT>TTT	p.V267F	XKR9_uc010lze.2_Missense_Mutation_p.V267F|XKR9_uc010lzd.2_Missense_Mutation_p.V135F	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	267	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			TAGGATTGTTGTTGGATTCAT	0.313													52	61					2.27781e-18	3.0023e-18	1	0	T	71646336	T	T	71646336	3	4	176	1	0	0	0	0	1	0	0	0	17506	1377	48	4	809	4	XKR9	8	71646336	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2012697	71646336	74717686	212	33058											
TRPA1	8989	broad.mit.edu	37	chr8	72973870	72973870	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaacttgcctgtgaagcaTggtctcatgacatccatcgg	10	10	11	10	1	1	2	1	2	1	0	4	3	2	3	2	3	3	1	2	3	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:72973870T>C	uc003xza.2	-	7	1109	c.934A>G	c.(934-936)ATG>GTG	p.M312V		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	312	ANK 8.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CTGTGAAGCATGGTCTCATGA	0.423													91	77					0	0	0	0	C	72973870	C	C	72973870	3	2	176	1	0	0	0	0	1	0	0	0	16644	1464	51	5	2509	5	TRPA1	8	72973870	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	1327534	72973870	73390152	213	33059											
ZFHX4	79776	broad.mit.edu	37	chr8	77775986	77775986	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacagcagcagaaaccagttCaggcaaagacatccaaagta	19	4	8	10	0	1	2	1	0	0	2	2	2	2	2	2	1	4	5	2	1	5	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:77775986C>G	uc003yav.2	+	11	10288	c.9901C>G	c.(9901-9903)CAG>GAG	p.Q3301E		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3297						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			gAAACCAGTTCAGGCAAAGAC	0.259										HNSCC(33;0.089)			3	3					0	0	0	0	G	77775986	G	G	77775986	3	3	176	1	0	0	0	0	1	0	0	0	17702	827	29	2	10074	2	ZFHX4	8	77775986	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	4802116	77775986	68588036	214	33060											
RALYL	138046	broad.mit.edu	37	chr8	85799925	85799926	+	Missense_Mutation	DNP	CC	AA	AA																															cagatcactctacagaggagCctgctgaaggagggccagat																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:85799925_85799926CC>AA	uc003ycq.3	+	9	1188_1189	c.772_773CC>AA	c.(772-774)CCT>AAT	p.P258N	RALYL_uc003ycr.3_Missense_Mutation_p.P258N|RALYL_uc003ycs.3_Missense_Mutation_p.P258N|RALYL_uc010lzy.2_Missense_Mutation_p.P247N|RALYL_uc003yct.3_Missense_Mutation_p.P271N|RALYL_uc003ycu.3_Missense_Mutation_p.P185N|RALYL_uc003ycv.3_Intron	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	258							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						TACAGAGGAGCCTGCTGAAGGA	0.51													85	79					0	0	0	0	AA	85799926	AA	AA	85799925	3	1	176	1	0	0	0	0	1	0	0	0	13085	739	26	4	841	4	RALYL	8	85799925	Missense_Mutation	DNP	CC	TCGA-CV-5441-01A-01D-1512-08	8023939	85799925	60564097	215	33061											
SLC26A7	115111	broad.mit.edu	37	chr8	92307834	92307834	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcagaacatgcagaatctcaCcacacagagtaacacaagcg	17	5	7	12	1	2	3	2	0	1	3	3	3	2	3	1	0	4	2	1	0	4	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:92307834C>A	uc003yex.2	+	5	658	c.380C>A	c.(379-381)ACC>AAC	p.T127N	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.T127N|SLC26A7_uc003yfa.2_Missense_Mutation_p.T127N	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	127	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CAGAATCTCACCACACAGAGT	0.498													11	152					0.00829132	0.00855558	1	0	A	92307834	A	A	92307834	3	1	176	1	0	0	0	0	1	0	0	0	14586	507	18	4	390	4	SLC26A7	8	92307834	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	6507909	92307834	54056188	216	33062											
RIMS2	9699	broad.mit.edu	37	chr8	105105870	105105870	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaggaaacaagaaaatcAggtaaggggatttcaacaac	19	5	11	6	0	2	1	2	0	0	1	2	4	2	4	0	5	3	1	0	5	7	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:105105870A>T	uc003yls.2	+	21	3134	c.2893A>T	c.(2893-2895)AGA>TGA	p.R965*	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.S1038C|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CAAGAAAATCAGGTAAGGGGA	0.368										HNSCC(12;0.0054)			50	28					0	0	0	0	T	105105870	T	T	105105870	4	4	176	1	0	0	0	0	0	1	0	0	13433	203	7	5		5	RIMS2	8	105105870	Nonsense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	12798036	105105870	41258152	217	33063											
PKHD1L1	93035	broad.mit.edu	37	chr8	110453596	110453596	+	Frame_Shift_Del	DEL	G	-	-																															tattcaggattaccaacaatGggaaagattcaggtatcagc																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:110453596delG	uc003yne.2	+	34	4296	c.4192delG	c.(4192-4194)GGGfs	p.G1398fs		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1398	Extracellular (Potential).|IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TACCAACAATGGGAAAGATTC	0.279										HNSCC(38;0.096)			---	---	---								-	110453596	-	-	110453596	7	5	176	1	0	1	0	1	0	0	0	0	12027	1348	47	0	4326	0	PKHD1L1	8	110453596	Frame_Shift_Del	DEL	G	TCGA-CV-5441-01A-01D-1512-08	5347726	110453596	35910426	218	33064											
CSMD3	114788	broad.mit.edu	37	chr8	113326813	113326813	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctcaatatgactccagtaGaatctagccgtaattcattg	12	12	8	9	1	3	2	2	1	1	1	4	2	4	2	2	1	1	3	2	1	6	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:113326813G>A	uc003ynu.2	-	48	7553	c.7394C>T	c.(7393-7395)TCT>TTT	p.S2465F	CSMD3_uc003yns.2_Missense_Mutation_p.S1667F|CSMD3_uc003ynt.2_Missense_Mutation_p.S2425F|CSMD3_uc011lhx.1_Missense_Mutation_p.S2361F|CSMD3_uc003ynw.1_Missense_Mutation_p.S176F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2465	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GACTCCAGTAGAATCTAGCCG	0.388										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	29					0	0	0	0	A	113326813	A	A	113326813	3	1	176	1	0	0	0	0	1	0	0	0	3963	942	33	2	3825	2	CSMD3	8	113326813	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2873217	113326813	33037209	219	33065											
CSMD3	114788	broad.mit.edu	37	chr8	113504751	113504751	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caaggctctattccatccagGtcttccatcatctcccatga	9	12	5	15	0	4	1	1	1	3	0	8	1	7	1	4	2	0	1	4	2	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:113504751G>T	uc003ynu.2	-	31	5404	c.5245C>A	c.(5245-5247)CCT>ACT	p.P1749T	CSMD3_uc003yns.2_Missense_Mutation_p.P1021T|CSMD3_uc003ynt.2_Missense_Mutation_p.P1709T|CSMD3_uc011lhx.1_Missense_Mutation_p.P1645T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1749	Extracellular (Potential).|Sushi 9.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTCCATCCAGGTCTTCCATCA	0.348										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	167					7.41945e-09	8.55963e-09	1	0	T	113504751	T	T	113504751	3	4	176	1	0	0	0	0	1	0	0	0	3963	1261	44	4	6042	4	CSMD3	8	113504751	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	177938	113504751	32859271	220	33066											
FAM135B	51059	broad.mit.edu	37	chr8	139380222	139380222	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaccgttccttgtatttcaGacatgatctttttggctcat	8	17	6	10	1	3	2	2	1	1	1	4	2	4	2	2	1	1	3	2	1	2	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:139380222G>A	uc003yuy.2	-	2	176	c.5C>T	c.(4-6)TCT>TTT	p.S2F	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	2										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTGTATTTCAGACATGATCTT	0.343										HNSCC(54;0.14)			77	99					0	0	0	0	A	139380222	A	A	139380222	3	1	176	1	0	0	0	0	1	0	0	0	5477	942	33	2	4291	2	FAM135B	8	139380222	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	25875471	139380222	6983800	221	33067											
COL22A1	169044	broad.mit.edu	37	chr8	139620234	139620234	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggtgatccattcttgcccTggtggaagaaacagaggtaa	11	9	12	9	1	1	3	0	1	1	2	2	4	2	4	3	4	2	1	3	4	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:139620234T>G	uc003yvd.2	-	57	4426	c.3979_splice	c.e57-1	p.G1327_splice	COL22A1_uc011ljo.1_Splice_Site_p.G607_splice	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ATTCTTGCCCTGGTGGAAGAA	0.383										HNSCC(7;0.00092)			21	108					0	0	0	0	G	139620234	G	G	139620234	5	3	176	1	0	0	0	0	0	0	1	0	3696	1594	55	5	939	5	COL22A1	8	139620234	Splice_Site	SNP	T	TCGA-CV-5441-01A-01D-1512-08	240012	139620234	6743788	222	33068											
KCNK9	51305	broad.mit.edu	37	chr8	140630763	140630763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcaggtccgggacgtccGccttgtacctgggccggctg	4	8	15	14	4	0	0	0	0	0	0	2	1	2	1	5	4	2	3	5	4	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:140630763G>A	uc003yvf.1	-	2	927	c.863C>T	c.(862-864)GCG>GTG	p.A288V	KCNK9_uc003yvg.1_Missense_Mutation_p.A288V|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	288	Cytoplasmic (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity	p.A288V(1)		ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CGGGACGTCCGCCTTGTACCT	0.667													77	62					0	0	0	0	A	140630763	A	A	140630763	3	1	176	1	0	0	0	0	1	0	0	0	8111	1087	38	1	265	1	KCNK9	8	140630763	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1010529	140630763	5733259	223	33069											
TSNARE1	203062	broad.mit.edu	37	chr8	143381940	143381940	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgctcctggccctgccaCatgttgtcactcccgttaaa	6	11	8	16	1	1	0	1	0	0	0	3	0	3	0	5	1	2	3	5	1	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:143381940C>A	uc003ywk.2	-	10	1315	c.1197G>T	c.(1195-1197)ATG>ATT	p.M399I	TSNARE1_uc011lju.1_Missense_Mutation_p.M398I|TSNARE1_uc003ywj.2_Missense_Mutation_p.M400I|TSNARE1_uc003ywl.3_Missense_Mutation_p.M180I	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	399					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GGCCCTGCCACATGTTGTCAC	0.607													15	163					2.62699e-14	3.27899e-14	1	0	A	143381940	A	A	143381940	3	1	176	1	0	0	0	0	1	0	0	0	16697	478	17	4	360	4	TSNARE1	8	143381940	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2751177	143381940	2982082	224	33070											
SLC39A4	55630	broad.mit.edu	37	chr8	145642057	145642057	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcccagagcctcttgatcCagagcgccctggccagaggt	7	6	12	16	2	1	4	0	1	1	3	2	4	2	4	6	2	2	0	6	2	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr8:145642057C>A	uc003zcq.2	-	1	217	c.117G>T	c.(115-117)CTG>CTT	p.L39L	SLC39A4_uc003zco.2_5'Flank|SLC39A4_uc003zcp.2_5'Flank	NM_130849	NP_570901	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter),	39	Extracellular (Potential).					cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			CCTCTTGATCCAGAGCGCCCT	0.682													15	11					2.31682e-05	2.5107e-05	1	0	A	145642057	A	A	145642057	2	1	176	1	0	0	0	0	0	0	0	1	14684	581	21	4		4	SLC39A4	8	145642057	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2260117	145642057	721965	225	33071											
DOCK8	81704	broad.mit.edu	37	chr9	312083	312083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcctgcagcaagtgagtgccGaggactttgagaagcagaac	12	7	13	9	1	0	3	0	2	0	2	1	6	1	4	2	1	5	3	2	1	3	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:312083G>A	uc003zgf.2	+	6	770	c.658G>A	c.(658-660)GAG>AAG	p.E220K	DOCK8_uc011lls.1_Missense_Mutation_p.E220K|DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Missense_Mutation_p.E152K|DOCK8_uc010mgt.2_Missense_Mutation_p.E152K|DOCK8_uc003zgg.2_Missense_Mutation_p.E152K|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	220					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AGTGAGTGCCGAGGACTTTGA	0.597													56	95					0	0	0	0	A	312083	A	A	312083	3	1	176	1	0	0	0	0	1	0	0	0	4715	1059	37	1	680	1	DOCK8	9	312083	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08		312083	140901348	226	33072											
KANK1	23189	broad.mit.edu	37	chr9	713363	713363	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctccctcaactctcagcTcatcagcaccctgtcgtcta	7	10	7	17	1	5	0	4	0	2	0	8	0	6	0	2	1	3	3	2	1	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:713363T>C	uc003zgl.1	+	7	3246	c.2597T>C	c.(2596-2598)CTC>CCC	p.L866P	KANK1_uc003zgm.2_Missense_Mutation_p.L866P|KANK1_uc003zgn.1_Missense_Mutation_p.L866P|KANK1_uc003zgo.1_Missense_Mutation_p.L866P|KANK1_uc003zgp.1_Missense_Mutation_p.L866P|KANK1_uc003zgq.2_Missense_Mutation_p.L708P|KANK1_uc003zgr.1_Missense_Mutation_p.L708P|KANK1_uc003zgs.1_Missense_Mutation_p.L708P	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	866					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		AACTCTCAGCTCATCAGCACC	0.512													91	94					0	0	0	0	C	713363	C	C	713363	3	2	176	1	0	0	0	0	1	0	0	0	8015	1551	54	5	2603	5	KANK1	9	713363	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	401280	713363	140500068	227	33073											
C9orf72	203228	broad.mit.edu	37	chr9	27561618	27561620	+	In_Frame_Del	DEL	ATC	-	-																															tcatgacagctgtcaccaatAtcatcatcattgagtactgt																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:27561618_27561620delATC	uc003zqq.2	-	5	725_727	c.628_630delGAT	c.(628-630)GATdel	p.D210del	C9orf72_uc003zqr.1_In_Frame_Del_p.D210del	NM_018325	NP_060795	Q96LT7	CI072_HUMAN	hypothetical protein LOC203228 isoform a	210										ovary(3)|central_nervous_system(1)	4		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		TGTCACCAATATCATCATCATTG	0.315													---	---	---								-	27561620	-	-	27561618	7	5	176	1	0	1	0	1	0	0	0	0	2507	446	16	0	847	0	C9orf72	9	27561618	In_Frame_Del	DEL	ATC	TCGA-CV-5441-01A-01D-1512-08	26848255	27561618	113651813	228	33074											
OR13J1	392309	broad.mit.edu	37	chr9	35869982	35869982	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccatcagcagcacgcagagCcggtggctcatgagcacgtg	9	5	13	14	3	2	2	2	1	0	1	2	2	2	2	2	2	4	5	2	2	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:35869982C>G	uc011lph.1	-	1	417	c.417G>C	c.(415-417)CGG>CGC	p.R139R		NM_001004487	NP_001004487	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			GCACGCAGAGCCGGTGGCTCA	0.637													34	68					0	0	0	0	G	35869982	G	G	35869982	2	3	176	1	0	0	0	0	0	0	0	1	10998	726	26	4		4	OR13J1	9	35869982	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	8308364	35869982	105343449	229	33075											
FOXD4L5	653427	broad.mit.edu	37	chr9	70177139	70177139	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgcgccttctgctttcttcGgtgccccggcatagacgggg	3	10	13	15	5	2	1	0	0	2	1	3	1	2	1	4	4	2	2	4	4	1	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:70177139G>T	uc010moc.2	-	1	1677	c.845C>A	c.(844-846)CCG>CAG	p.P282Q		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	282					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						TGCTTTCTTCGGTGCCCCGGC	0.677													17	97					3.08376e-08	3.53405e-08	1	0	T	70177139	T	T	70177139	3	4	176	1	0	0	0	0	1	0	0	0	6036	1116	39	3	409	3	FOXD4L5	9	70177139	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	34307157	70177139	71036292	230	33076											
PIP5K1B	8395	broad.mit.edu	37	chr9	71503929	71503929	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaacctctaatagaactGtctaaccctggagccagtgg	12	9	10	10	0	2	2	0	1	2	1	2	3	2	3	3	2	4	0	3	2	5	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:71503929G>A	uc004agu.2	+	7	656	c.351G>A	c.(349-351)CTG>CTA	p.L117L	PIP5K1B_uc011lrq.1_Silent_p.L117L|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	117	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		TAATAGAACTGTCTAACCCTG	0.383													54	130					0	0	0	0	A	71503929	A	A	71503929	2	1	176	1	0	0	0	0	0	0	0	1	11995	1364	48	4		4	PIP5K1B	9	71503929	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1326790	71503929	69709502	231	33077											
TJP2	9414	broad.mit.edu	37	chr9	71845118	71845118	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggacctcggcggagcaggaGggccttcaagaaggagacca	11	3	17	10	2	1	2	1	0	0	2	2	6	1	5	3	6	1	1	3	6	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:71845118G>T	uc004ahe.2	+	11	1841	c.1641G>T	c.(1639-1641)GAG>GAT	p.E547D	TJP2_uc011lrs.1_Missense_Mutation_p.E524D|TJP2_uc011lrt.1_Missense_Mutation_p.E524D|TJP2_uc004ahd.2_Missense_Mutation_p.E547D|TJP2_uc004ahf.2_Missense_Mutation_p.E547D|TJP2_uc011lru.1_Missense_Mutation_p.E551D|TJP2_uc011lrv.1_Missense_Mutation_p.E569D	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	547	PDZ 3.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						CGGAGCAGGAGGGCCTTCAAG	0.517													37	55					3.78316e-11	4.51538e-11	1	0	T	71845118	T	T	71845118	3	4	176	1	0	0	0	0	1	0	0	0	15996	991	35	4	1840	4	TJP2	9	71845118	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	341189	71845118	69368313	232	33078											
TMC1	117531	broad.mit.edu	37	chr9	75445586	75445586	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcgaaacaagaaaatggcaGctgcacgagcaggttggaga	15	5	14	7	2	0	2	0	0	0	2	0	5	0	2	0	3	5	5	0	3	4	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:75445586G>T	uc004aiz.1	+	23	2788	c.2248G>T	c.(2248-2250)GCT>TCT	p.A750S	TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.A604S|TMC1_uc010mpa.1_Intron	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	750	Cytoplasmic (Potential).|Poly-Ala.				sensory perception of sound	integral to membrane				ovary(1)	1						GAAAATGGCAGCTGCACGAGC	0.284													9	33					0.00829132	0.00855558	1	0	T	75445586	T	T	75445586	3	4	176	1	0	0	0	0	1	0	0	0	16050	971	34	4	2322	4	TMC1	9	75445586	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3600468	75445586	65767845	233	33079											
S1PR3	1903	broad.mit.edu	37	chr9	91616672	91616672	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcacaatctccctgactgctCtaccatcctgcccctctact	7	11	4	19	0	3	1	0	1	3	0	5	1	4	1	5	0	4	2	5	0	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:91616672C>T	uc004aqe.2	+	2	953	c.557C>T	c.(556-558)TCT>TTT	p.S186F		NM_005226	NP_005217	Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	186	Extracellular (By similarity).				anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)|central_nervous_system(1)|skin(1)	5						CCTGACTGCTCTACCATCCTG	0.577											OREG0019291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	67					0	0	0	0	T	91616672	T	T	91616672	3	4	176	1	0	0	0	0	1	0	0	0	13860	913	32	2	559	2	S1PR3	9	91616672	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	16171086	91616672	49596759	234	33080											
OR1N2	138882	broad.mit.edu	37	chr9	125315759	125315759	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatgctggccaacattcataCccagagtcagatcatctcgt	12	10	7	12	1	4	2	3	0	1	2	5	2	4	2	2	1	3	1	2	1	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:125315759C>A	uc011lyx.1	+	1	311	c.311C>A	c.(310-312)ACC>AAC	p.T104N		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	104	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						AACATTCATACCCAGAGTCAG	0.478													86	162					1.12511e-72	1.8156e-72	1	0	A	125315759	A	A	125315759	3	1	176	1	0	0	0	0	1	0	0	0	11024	507	18	4	313	4	OR1N2	9	125315759	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	33699087	125315759	15897672	235	33081											
NOTCH1	4851	broad.mit.edu	37	chr9	139407552	139407552	+	Frame_Shift_Del	DEL	C	-	-																															tggttcagacatgggttggaCgcacactcgttgatgttggt																								rs143360959	by1000genomes	TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:139407552delC	uc004chz.2	-	15	2388	c.2388delG	c.(2386-2388)GCGfs	p.A796fs	NOTCH1_uc004cia.1_Frame_Shift_Del_p.A26fs	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	796	Extracellular (Potential).|EGF-like 21; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ATGGGTTGGACGCACACTCGT	0.622			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								-	139407552	-	-	139407552	7	5	176	1	0	1	0	1	0	0	0	0	10601	523	19	0	5359	0	NOTCH1	9	139407552	Frame_Shift_Del	DEL	C	TCGA-CV-5441-01A-01D-1512-08	14091793	139407552	1805879	236	33082											
NDOR1	27158	broad.mit.edu	37	chr9	140108321	140108321	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcctgggcgatgaccagcAtgagctggggtgagtctgcg	6	8	18	9	2	1	3	0	3	1	0	1	4	1	3	2	3	4	2	2	3	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr9:140108321A>G	uc004clw.2	+	4	512	c.401A>G	c.(400-402)CAT>CGT	p.H134R	NDOR1_uc004clx.2_Missense_Mutation_p.H134R|NDOR1_uc011mes.1_Missense_Mutation_p.H134R|NDOR1_uc004cly.2_Missense_Mutation_p.H134R	NM_014434	NP_055249	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	134	Flavodoxin-like.				cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GATGACCAGCATGAGCTGGGG	0.677													17	10					0	0	0	0	G	140108321	G	G	140108321	3	3	176	1	0	0	0	0	1	0	0	0	10303	217	8	5	415	5	NDOR1	9	140108321	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	700769	140108321	1105110	237	33083											
ZEB1	6935	broad.mit.edu	37	chr10	31816121	31816121	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgacagggctgaaagtcaaGcaagcagcttaggacaaaaa	18	5	11	7	0	1	2	1	2	0	0	1	3	1	3	0	2	3	4	0	2	6	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr10:31816121G>T	uc001ivs.3	+	9	3367	c.3304G>T	c.(3304-3306)GCA>TCA	p.A1102S	ZEB1_uc001ivr.3_Missense_Mutation_p.A884S|ZEB1_uc010qee.1_Missense_Mutation_p.A884S|ZEB1_uc010qef.1_Missense_Mutation_p.A884S|ZEB1_uc001ivt.3_Missense_Mutation_p.A884S|ZEB1_uc001ivu.3_Missense_Mutation_p.A1103S|ZEB1_uc001ivv.3_Missense_Mutation_p.A1082S|ZEB1_uc010qeh.1_Missense_Mutation_p.A1035S|ZEB1_uc009xlp.2_Missense_Mutation_p.A1086S	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	1102	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				TGAAAGTCAAGCAAGCAGCTT	0.284													16	25					1.33834e-09	1.55788e-09	1	0	T	31816121	T	T	31816121	3	4	176	1	0	0	0	0	1	0	0	0	17690	971	34	4	3352	4	ZEB1	10	31816121	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08		31816121	103718626	238	33084											
ARHGAP22	58504	broad.mit.edu	37	chr10	49763518	49763518	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggcctacctgggctgatCtcaaagaggtgcttccctgg	7	10	12	12	0	2	2	2	1	1	1	4	2	3	2	3	4	2	2	3	4	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr10:49763518C>A	uc001jgt.2	-	3	609	c.312G>T	c.(310-312)GAG>GAT	p.E104D	ARHGAP22_uc001jgu.2_Missense_Mutation_p.E104D|ARHGAP22_uc010qgl.1_Missense_Mutation_p.E104D|ARHGAP22_uc010qgm.1_Missense_Mutation_p.E110D|ARHGAP22_uc001jgv.2_5'UTR	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	104	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						CTGGGCTGATCTCAAAGAGGT	0.577													47	108					2.55665e-31	3.75168e-31	1	0	A	49763518	A	A	49763518	3	1	176	1	0	0	0	0	1	0	0	0	872	912	32	2	1816	2	ARHGAP22	10	49763518	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	17947397	49763518	85771229	239	33085											
OGDHL	55753	broad.mit.edu	37	chr10	50946031	50946031	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggatctgccggcgcagcaCgtggaagtagttggccggtg	7	7	17	10	4	1	0	0	0	1	0	1	2	1	2	2	5	2	4	2	5	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr10:50946031C>A	uc001jie.2	-	19	2621	c.2479G>T	c.(2479-2481)GTG>TTG	p.V827L	OGDHL_uc009xog.2_Missense_Mutation_p.V854L|OGDHL_uc010qgt.1_Missense_Mutation_p.V770L|OGDHL_uc010qgu.1_Missense_Mutation_p.V618L	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	827					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						CGGCGCAGCACGTGGAAGTAG	0.652													70	169					1.79293e-35	2.71561e-35	1	0	A	50946031	A	A	50946031	3	1	176	1	0	0	0	0	1	0	0	0	10894	536	19	3	573	3	OGDHL	10	50946031	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1182513	50946031	84588716	240	33086											
PCDH15	65217	broad.mit.edu	37	chr10	56077052	56077052	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagttctcaactcaggtatGgcagcttgataagtgagtgg	10	11	14	6	0	2	2	2	2	1	0	3	3	2	3	0	4	2	4	0	4	3	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr10:56077052G>T	uc001jju.1	-	8	1250	c.855C>A	c.(853-855)GCC>GCA	p.A285A	PCDH15_uc010qhq.1_Silent_p.A290A|PCDH15_uc010qhr.1_Silent_p.A285A|PCDH15_uc010qhs.1_Silent_p.A290A|PCDH15_uc010qht.1_Silent_p.A285A|PCDH15_uc010qhu.1_Silent_p.A285A|PCDH15_uc001jjv.1_Silent_p.A263A|PCDH15_uc010qhv.1_Silent_p.A285A|PCDH15_uc010qhw.1_Silent_p.A248A|PCDH15_uc010qhx.1_Silent_p.A285A|PCDH15_uc010qhy.1_Silent_p.A290A|PCDH15_uc010qhz.1_Silent_p.A285A|PCDH15_uc010qia.1_Silent_p.A263A|PCDH15_uc010qib.1_Silent_p.A263A|PCDH15_uc001jjw.2_Silent_p.A285A	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	285	Cadherin 3.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACTCAGGTATGGCAGCTTGAT	0.413										HNSCC(58;0.16)			29	34					9.65021e-13	1.18455e-12	1	0	T	56077052	T	T	56077052	2	4	176	1	0	0	0	0	0	0	0	1	11565	1335	47	4		4	PCDH15	10	56077052	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	5131021	56077052	79457695	241	33087											
CTNNA3	29119	broad.mit.edu	37	chr10	68280484	68280484	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atttccatggtgtttttgacCgcttgacttttgggtcttgc	4	19	10	8	1	1	2	0	2	1	0	2	2	2	2	2	2	1	2	2	2	0	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr10:68280484C>A	uc009xpn.1	-	11	1545	c.1422G>T	c.(1420-1422)GCG>GCT	p.A474A	CTNNA3_uc001jmw.2_Silent_p.A474A|CTNNA3_uc001jmx.3_Silent_p.A474A	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	474					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TGTTTTTGACCGCTTGACTTT	0.313													43	94					3.7052e-28	5.39128e-28	1	0	A	68280484	A	A	68280484	2	1	176	1	0	0	0	0	0	0	0	1	4031	639	23	3		3	CTNNA3	10	68280484	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	12203432	68280484	67254263	242	33088											
GHITM	27069	broad.mit.edu	37	chr10	85901368	85901368	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcacgaagaatcaatggCtgttaacacctagcagggta	14	8	9	10	1	2	1	2	0	0	1	2	2	2	1	2	2	2	4	2	2	6	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr10:85901368C>T	uc001kcs.1	+	2	316	c.112C>T	c.(112-114)CTG>TTG	p.L38L	GHITM_uc010qma.1_5'UTR|GHITM_uc010qmb.1_5'Flank	NM_014394	NP_055209	Q9H3K2	GHITM_HUMAN	growth hormone inducible transmembrane protein	38					apoptosis	integral to membrane|mitochondrial inner membrane					0						GAATCAATGGCTGTTAACACC	0.448													55	128					0	0	0	0	T	85901368	T	T	85901368	2	4	176	1	0	0	0	0	0	0	0	1	6407	796	28	4		4	GHITM	10	85901368	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	17620884	85901368	49633379	243	33089											
PKD2L1	9033	broad.mit.edu	37	chr10	102050189	102050189	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcctgaaacccagcctcCtgctctggcagcctctggac	6	10	8	17	0	3	1	0	1	3	0	5	2	4	2	5	2	4	2	5	2	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr10:102050189C>A	uc001kqx.1	-	13	2478	c.2095G>T	c.(2095-2097)GGA>TGA	p.G699*	PKD2L1_uc009xwm.1_Nonsense_Mutation_p.G652*	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	699	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		ACCCAGCCTCCTGCTCTGGCA	0.517													17	41					7.21436e-19	9.63155e-19	1	0	A	102050189	A	A	102050189	4	1	176	1	0	0	0	0	0	1	0	0	12022	690	24	4	338	4	PKD2L1	10	102050189	Nonsense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	16148821	102050189	33484558	244	33090											
MKI67	4288	broad.mit.edu	37	chr10	129904753	129904753	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctactgctggtttgggtGtgtgcatggctttgcctgct	3	15	13	10	0	0	0	0	0	0	0	0	0	0	0	2	3	5	5	2	3	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr10:129904753G>A	uc001lke.2	-	13	5546	c.5351C>T	c.(5350-5352)ACA>ATA	p.T1784I	MKI67_uc001lkf.2_Missense_Mutation_p.T1424I|MKI67_uc009yav.1_Missense_Mutation_p.T1359I|MKI67_uc009yaw.1_Missense_Mutation_p.T934I	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1784	7.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGGTTTGGGTGTGTGCATGGC	0.468													86	209					0	0	0	0	A	129904753	A	A	129904753	3	1	176	1	0	0	0	0	1	0	0	0	9651	1377	48	4	4431	4	MKI67	10	129904753	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	27854564	129904753	5629994	245	33091											
KNDC1	85442	broad.mit.edu	37	chr10	135011840	135011841	+	Splice_Site	DNP	GG	TT	TT																															ctcagccccctggctccccaGgcttcctgccggtgaacagc																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr10:135011840_135011841GG>TT	uc001llz.1	+	13	1908	c.1907_splice	c.e13-1	p.G636_splice	KNDC1_uc001lma.1_Splice_Site_p.G571_splice|KNDC1_uc001lmb.1_Splice_Site_p.G48_splice	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TGGCTCCCCAGGCTTCCTGCCG	0.723													5	9					0	0	0	0	TT	135011841	TT	TT	135011840	5	4	176	1	0	0	0	0	0	0	1	0	8465	1014	35	4	1956	4	KNDC1	10	135011840	Splice_Site	DNP	GG	TCGA-CV-5441-01A-01D-1512-08	5107087	135011840	522907	246	33092											
MUC6	4588	broad.mit.edu	37	chr11	1016760	1016760	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tacttggagtcaccaaggagGtggagaaaggtggaacgtga	13	7	16	5	1	1	2	1	1	0	1	1	6	1	5	1	6	2	0	1	6	4	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:1016760G>T	uc001lsw.2	-	31	6092	c.6041C>A	c.(6040-6042)ACC>AAC	p.T2014N		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	2014	Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CACCAAGGAGGTGGAGAAAGG	0.537													46	624					1.97e-11	2.37869e-11	1	0	T	1016760	T	T	1016760	3	4	176	1	0	0	0	0	1	0	0	0	10033	1261	44	4	1290	4	MUC6	11	1016760	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08		1016760	133989756	247	33093											
CHRNA10	57053	broad.mit.edu	37	chr11	3688905	3688905	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catccacgcggcacgagctgCgcgtgatggccggcgcgtcc	5	5	15	16	8	0	1	0	1	0	0	2	2	2	1	3	3	2	2	3	3	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:3688905C>G	uc001lyf.2	-	4	524	c.452G>C	c.(451-453)CGC>CCC	p.R151P	CHRNA10_uc010qxt.1_5'UTR|CHRNA10_uc010qxu.1_5'UTR	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	151	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	GCACGAGCTGCGCGTGATGGC	0.711													5	17					0	0	0	0	G	3688905	G	G	3688905	3	3	176	1	0	0	0	0	1	0	0	0	3397	768	27	3	908	3	CHRNA10	11	3688905	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2672145	3688905	131317611	248	33094											
OR51V1	283111	broad.mit.edu	37	chr11	5221655	5221655	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgaatgatcccccacaggatCcccagcactgtgtacacagt	11	7	8	15	1	0	1	0	1	0	0	2	3	2	2	4	1	2	2	4	1	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:5221655C>T	uc010qyz.1	-	1	276	c.276G>A	c.(274-276)GGG>GGA	p.G92G		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCACAGGATCCCCAGCACTG	0.547													24	58					0	0	0	0	T	5221655	T	T	5221655	2	4	176	1	0	0	0	0	0	0	0	1	11161	842	30	2		2	OR51V1	11	5221655	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1532750	5221655	129784861	249	33095											
TRIM22	10346	broad.mit.edu	37	chr11	5717794	5717794	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagatcttctgtaaggaggAtggaaaagtcatttgctggg	11	11	13	6	0	3	1	1	0	2	1	3	4	3	4	1	4	1	2	1	4	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:5717794A>G	uc001mbr.2	+	2	609	c.332A>G	c.(331-333)GAT>GGT	p.D111G	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Missense_Mutation_p.D111G|TRIM22_uc009yes.2_Missense_Mutation_p.D111G|TRIM22_uc010qzm.1_Missense_Mutation_p.M17V|TRIM22_uc009yeu.2_5'UTR	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	111	B box-type.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TGTAAGGAGGATGGAAAAGTC	0.483													31	56					0	0	0	0	G	5717794	G	G	5717794	3	3	176	1	0	0	0	0	1	0	0	0	16563	333	12	5	334	5	TRIM22	11	5717794	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	496139	5717794	129288722	250	33096											
OR56A1	120796	broad.mit.edu	37	chr11	6048725	6048725	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagcagggagaggaggctGagcaggtagtacaggggctg	10	5	19	7	0	0	2	0	1	0	1	1	4	1	3	1	6	3	6	1	6	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:6048725G>A	uc010qzw.1	-	1	210	c.210C>T	c.(208-210)CTC>CTT	p.L70L		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAGGAGGCTGAGCAGGTAGT	0.597													26	70					0	0	0	0	A	6048725	A	A	6048725	2	1	176	1	0	0	0	0	0	0	0	1	11187	1277	45	2		2	OR56A1	11	6048725	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	330931	6048725	128957791	251	33097											
OR6A2	8590	broad.mit.edu	37	chr11	6815970	6815970	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcccttctatacatttctgcTagctttcttggggtcaggat	6	17	8	10	0	4	0	1	0	3	0	5	1	5	1	1	3	3	2	1	3	3	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:6815970T>C	uc001mes.1	-	1	1170	c.970A>G	c.(970-972)AGC>GGC	p.S324G		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	324	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ACATTTCTGCTAGCTTTCTTG	0.443													19	81					0	0	0	0	C	6815970	C	C	6815970	3	2	176	1	0	0	0	0	1	0	0	0	11240	1522	53	5	17	5	OR6A2	11	6815970	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	767245	6815970	128190546	252	33098											
PIK3C2A	5286	broad.mit.edu	37	chr11	17169081	17169081	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactgttcgggccagattttGacacattgcactgaaggtca	10	12	10	9	1	1	3	1	2	0	1	2	3	1	3	1	2	2	2	1	2	2	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:17169081G>C	uc001mmq.3	-	5	1609	c.1543C>G	c.(1543-1545)CAA>GAA	p.Q515E	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.Q135E|PIK3C2A_uc001mmr.3_Intron|PIK3C2A_uc010rcx.1_Missense_Mutation_p.Q515E|PIK3C2A_uc009ygv.1_Missense_Mutation_p.Q515E	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	515					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	GCCAGATTTTGACACATTGCA	0.358													15	43					0	0	0	0	C	17169081	C	C	17169081	3	2	176	1	0	0	0	0	1	0	0	0	11964	1299	45	2	3629	2	PIK3C2A	11	17169081	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	10353111	17169081	117837435	253	33099											
OR4X2	119764	broad.mit.edu	37	chr11	48267094	48267094	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgggtgggaggcttcatgCattcctttgcacaaatcctt	8	13	10	10	0	1	0	1	0	0	0	3	1	3	1	2	3	2	3	2	3	1	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:48267094C>T	uc001ngs.1	+	1	439	c.439C>T	c.(439-441)CAT>TAT	p.H147Y		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGCTTCATGCATTCCTTTGC	0.498													68	129					0	0	0	0	T	48267094	T	T	48267094	3	4	176	1	0	0	0	0	1	0	0	0	11139	710	25	4	441	4	OR4X2	11	48267094	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	31098013	48267094	86739422	254	33100											
OR4C46	119749	broad.mit.edu	37	chr11	51515641	51515641	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtgatggcctatgaccaCtatgtggccatctgcaagcc	9	10	10	12	0	1	2	0	2	1	0	1	2	1	2	4	2	2	1	4	2	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:51515641C>T	uc010ric.1	+	1	360	c.360C>T	c.(358-360)CAC>CAT	p.H120H		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCTATGACCACTATGTGGCCA	0.488													60	88					0	0	0	0	T	51515641	T	T	51515641	2	4	176	1	0	0	0	0	0	0	0	1	11105	564	20	4		4	OR4C46	11	51515641	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	3248547	51515641	83490875	255	33101											
OR4A16	81327	broad.mit.edu	37	chr11	55110944	55110944	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tactctgtgataaaatcgctAtttccttgtcagcttgcatg	9	16	7	9	1	2	1	1	1	1	0	4	1	3	1	1	0	3	3	1	0	4	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:55110944A>G	uc010rie.1	+	1	268	c.268A>G	c.(268-270)ATT>GTT	p.I90V		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						TAAAATCGCTATTTCCTTGTC	0.438													95	111					0	0	0	0	G	55110944	G	G	55110944	3	3	176	1	0	0	0	0	1	0	0	0	11095	449	16	5	270	5	OR4A16	11	55110944	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	3595303	55110944	79895572	256	33102											
OR5D13	390142	broad.mit.edu	37	chr11	55540998	55540998	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccagaaatccaggttccaCtctttctggttttcttgttc	7	16	6	12	0	3	1	0	0	3	1	6	1	5	1	3	2	0	3	3	2	1	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:55540998C>A	uc010ril.1	+	1	85	c.85C>A	c.(85-87)CTC>ATC	p.L29I		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				CCAGGTTCCACTCTTTCTGGT	0.393													56	67					3.53049e-34	5.30085e-34	1	0	A	55540998	A	A	55540998	3	1	176	1	0	0	0	0	1	0	0	0	11208	565	20	4	87	4	OR5D13	11	55540998	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	430054	55540998	79465518	257	33103											
OR5T2	219464	broad.mit.edu	37	chr11	55999771	55999771	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggaacttggtctcacataCatgaagaggattgtcccata	12	11	9	9	0	1	2	1	1	1	1	3	4	2	4	1	3	2	0	1	3	4	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:55999771C>A	uc010rjc.1	-	1	891	c.891G>T	c.(889-891)ATG>ATT	p.M297I		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	297	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GTCTCACATACATGAAGAGGA	0.423													75	91					7.577e-32	1.1182e-31	1	0	A	55999771	A	A	55999771	3	1	176	1	0	0	0	0	1	0	0	0	11236	478	17	4	187	4	OR5T2	11	55999771	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	458773	55999771	79006745	258	33104											
P2RX3	5024	broad.mit.edu	37	chr11	57114095	57114095	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggtggtaaccaaggtgaaggGctccggactctacgccaaca	11	6	13	11	2	1	1	0	1	1	0	2	2	2	2	3	5	3	2	3	5	5	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:57114095G>T	uc001nju.2	+	2	273	c.197G>T	c.(196-198)GGC>GTC	p.G66V		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	66	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						AAGGTGAAGGGCTCCGGACTC	0.547													92	41					4.37026e-21	6.06915e-21	1	0	T	57114095	T	T	57114095	3	4	176	1	0	0	0	0	1	0	0	0	11395	1203	42	4	203	4	P2RX3	11	57114095	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1114324	57114095	77892421	259	33105											
OR5B17	219965	broad.mit.edu	37	chr11	58125729	58125729	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catagtgtagaacacagatgCaattttgtctgtgtccatgg	11	13	10	7	0	1	2	0	0	1	2	2	2	2	2	1	1	2	2	1	1	4	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:58125729C>A	uc010rke.1	-	1	814	c.814G>T	c.(814-816)GCA>TCA	p.A272S		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	272	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AACACAGATGCAATTTTGTCT	0.398													104	68					3.92243e-71	6.31e-71	1	0	A	58125729	A	A	58125729	3	1	176	1	0	0	0	0	1	0	0	0	11203	710	25	4	132	4	OR5B17	11	58125729	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1011634	58125729	76880787	260	33106											
OR4D6	219983	broad.mit.edu	37	chr11	59224522	59224522	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtttttcttgtttgtggTcttctttgctgtgtatgtag	3	22	12	4	0	3	0	0	0	3	0	3	1	3	1	0	2	1	5	0	2	2	8			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:59224522T>A	uc010rku.1	+	1	89	c.89T>A	c.(88-90)GTC>GAC	p.V30D		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTGTTTGTGGTCTTCTTTGCT	0.463													92	119					0	0	0	0	A	59224522	A	A	59224522	3	1	176	1	0	0	0	0	1	0	0	0	11112	1667	58	5	91	5	OR4D6	11	59224522	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	1098793	59224522	75781994	261	33107											
RELA	5970	broad.mit.edu	37	chr11	65422031	65422031	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagggtactccatcagcaTgggctcagttgtgtgggggg	6	10	16	9	0	3	0	3	0	0	0	4	0	4	0	1	5	2	4	1	5	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:65422031T>G	uc001ofg.2	-	11	1614	c.1474A>C	c.(1474-1476)ATG>CTG	p.M492L	RELA_uc001ofh.2_Missense_Mutation_p.M489L|RELA_uc010ron.1_Missense_Mutation_p.M503L|RELA_uc009yqr.2_Missense_Mutation_p.M439L|RELA_uc001ofe.2_3'UTR|RELA_uc001off.2_Intron	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	492					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4						TCCATCAGCATGGGCTCAGTT	0.597													34	138					0	0	0	0	G	65422031	G	G	65422031	3	3	176	1	0	0	0	0	1	0	0	0	13281	1464	51	5	185	5	RELA	11	65422031	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	6197509	65422031	69584485	262	33108											
EFEMP2	30008	broad.mit.edu	37	chr11	65638688	65638688	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaggggttggggtgttgagCgggaggcactggtggcgggg	4	7	25	5	2	0	1	0	1	0	0	0	2	0	2	0	10	1	4	0	10	0	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:65638688C>T	uc001ofy.3	-	4	501	c.307G>A	c.(307-309)GCT>ACT	p.A103T	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.A103T	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	103				AQHPNPCPP -> VNTQPLPT (in Ref. 2; AAC62108).	blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		GGGTGTTGAGCGGGAGGCACT	0.652													35	121					0	0	0	0	T	65638688	T	T	65638688	3	4	176	1	0	0	0	0	1	0	0	0	4964	768	27	1	1056	1	EFEMP2	11	65638688	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	216657	65638688	69367828	263	33109											
CLPB	81570	broad.mit.edu	37	chr11	72004448	72004448	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttctcagggtgcagtggtGcccggatgtccagtctgcga	5	10	14	12	2	2	0	1	0	2	0	4	2	3	1	3	3	3	1	3	3	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:72004448G>A	uc001osj.2	-	17	2137	c.2087C>T	c.(2086-2088)GCA>GTA	p.A696V	CLPB_uc010rqx.1_Missense_Mutation_p.A651V|CLPB_uc010rqy.1_Missense_Mutation_p.A637V|CLPB_uc001osk.2_Missense_Mutation_p.A666V|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Missense_Mutation_p.A495V|CLPB_uc001osi.2_Missense_Mutation_p.A304V	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	696					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						GTGCAGTGGTGCCCGGATGTC	0.602													36	153					0	0	0	0	A	72004448	A	A	72004448	3	1	176	1	0	0	0	0	1	0	0	0	3566	1319	46	4	40	4	CLPB	11	72004448	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	6365760	72004448	63002068	264	33110											
TYR	7299	broad.mit.edu	37	chr11	88911460	88911460	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttggggaccaaactgcacAgagagacgactcttggtgag	11	9	13	8	1	1	3	0	1	1	2	1	6	1	4	1	3	2	1	1	3	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:88911460A>C	uc001pcs.2	+	1	421	c.339A>C	c.(337-339)ACA>ACC	p.T113T		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	113	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	CAAACTGCACAGAGAGACGAC	0.463									Oculocutaneous_Albinism				27	39					0	0	0	0	C	88911460	C	C	88911460	2	2	176	1	0	0	0	0	0	0	0	1	16881	175	7	5		5	TYR	11	88911460	Silent	SNP	A	TCGA-CV-5441-01A-01D-1512-08	16907012	88911460	46095056	265	33111											
GRIA4	2893	broad.mit.edu	37	chr11	105623920	105623920	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcactacgaatggaactgttTtgtcttcctgtatgacacag	10	14	8	9	1	2	1	1	1	1	0	3	3	3	2	1	1	2	2	1	1	4	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:105623920T>C	uc001pix.2	+	4	907	c.461T>C	c.(460-462)TTT>TCT	p.F154S	GRIA4_uc001piu.1_Missense_Mutation_p.F154S|GRIA4_uc001piw.2_Missense_Mutation_p.F154S|GRIA4_uc001piv.2_Missense_Mutation_p.F154S|GRIA4_uc009yxk.1_Missense_Mutation_p.F154S	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	154	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TGGAACTGTTTTGTCTTCCTG	0.433													46	58					0	0	0	0	C	105623920	C	C	105623920	3	2	176	1	0	0	0	0	1	0	0	0	6809	1841	64	5	471	5	GRIA4	11	105623920	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	16712460	105623920	29382596	266	33112											
OR8D4	338662	broad.mit.edu	37	chr11	123777721	123777721	+	Frame_Shift_Del	DEL	G	-	-																															cctgctccagcacttatattGatgagcttttgatttttgtc																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr11:123777721delG	uc010saa.1	+	1	583	c.583delG	c.(583-585)GATfs	p.D195fs		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		CACTTATATTGATGAGCTTTT	0.373													---	---	---								-	123777721	-	-	123777721	7	5	176	1	0	1	0	1	0	0	0	0	11287	1290	45	0	585	0	OR8D4	11	123777721	Frame_Shift_Del	DEL	G	TCGA-CV-5441-01A-01D-1512-08	18153801	123777721	11228795	267	33113											
WNK1	65125	broad.mit.edu	37	chr12	993327	993327	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actcaagttgttcattctgcGggaaggcggtttatagtgag	9	13	13	6	2	3	1	2	1	1	0	3	2	3	2	0	3	1	3	0	3	4	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:993327G>A	uc001qio.3	+	18	4269	c.3762G>A	c.(3760-3762)GCG>GCA	p.A1254A	WNK1_uc001qip.3_Silent_p.A1007A|WNK1_uc001qir.3_Silent_p.A427A	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1254					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TTCATTCTGCGGGAAGGCGGT	0.373													62	137					0	0	0	0	A	993327	A	A	993327	2	1	176	1	0	0	0	0	0	0	0	1	17445	1103	39	1		1	WNK1	12	993327	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08		993327	132858568	268	33114											
NDUFA9	4704	broad.mit.edu	37	chr12	4764024	4764024	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaggtaatcataccctatcGgtgtgataaatatgacatca	15	11	7	8	1	2	2	2	2	0	0	3	2	2	2	1	2	1	1	1	2	6	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:4764024G>A	uc001qnc.2	+	3	264	c.254G>A	c.(253-255)CGG>CAG	p.R85Q	NDUFA9_uc009zei.1_Missense_Mutation_p.R85Q	NM_005002	NP_004993	Q16795	NDUA9_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	85					mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	ATACCCTATCGGTGTGATAAA	0.403													4	82					0	0	0	0	A	4764024	A	A	4764024	3	1	176	1	0	0	0	0	1	0	0	0	10326	1116	39	1	264	1	NDUFA9	12	4764024	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3770697	4764024	129087871	269	33115											
C1R	715	broad.mit.edu	37	chr12	7241888	7241888	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcaggggtaggacggctgtaCctgtagctggtcataggggc	7	9	17	8	1	2	0	2	0	0	0	2	1	2	1	1	7	2	5	1	7	4	4	rs112305412		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:7241888C>T	uc010sfy.1	-	5	827	c.768_splice	c.e5+1	p.Q256_splice	C1R_uc010sfz.1_Splice_Site_p.Q270_splice|C1R_uc010sga.1_Splice_Site_p.Q222_splice	NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent						complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GACGGCTGTACCTGTAGCTGG	0.592													13	20					0	0	0	0	T	7241888	T	T	7241888	5	4	176	1	0	0	0	0	0	0	1	0	1981	521	18	4	1055	4	C1R	12	7241888	Splice_Site	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2477864	7241888	126610007	270	33116											
SLC2A3	6515	broad.mit.edu	37	chr12	8083212	8083212	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcggccatagctcttcagaCccaaggatgaattccagacc	12	7	9	13	1	2	3	1	1	1	2	3	4	3	4	4	2	2	1	4	2	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:8083212C>A	uc001qtr.2	-	5	799	c.537G>T	c.(535-537)GGG>GGT	p.G179G	SLC2A3_uc001qts.2_Silent_p.G179G	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	179	Extracellular (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		GCTCTTCAGACCCAAGGATGA	0.433													25	92					5.45024e-15	6.85249e-15	1	0	A	8083212	A	A	8083212	2	1	176	1	0	0	0	0	0	0	0	1	14609	494	18	4		4	SLC2A3	12	8083212	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	841324	8083212	125768683	271	33117											
PHC1	1911	broad.mit.edu	37	chr12	9089872	9089872	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgcaggcgtggaccccgcCgcagctcctctgacattgcc	5	8	11	17	4	1	1	0	1	1	0	3	2	2	2	5	2	2	3	5	2	0	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:9089872C>T	uc001qvd.2	+	13	2734	c.2578C>T	c.(2578-2580)CGC>TGC	p.R860C	PHC1_uc001qve.2_Missense_Mutation_p.R860C	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	860					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						TGGACCCCGCCGCAGCTCCTC	0.522													5	11					0	0	0	0	T	9089872	T	T	9089872	3	4	176	1	0	0	0	0	1	0	0	0	11871	652	23	1	2624	1	PHC1	12	9089872	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1006660	9089872	124762023	272	33118											
KLRC3	3823	broad.mit.edu	37	chr12	10569334	10569334	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgttacgaaacacaccaatCcatgaggaaggtaaaatgct	16	8	8	9	1	0	1	0	1	0	0	1	3	1	2	2	2	3	3	2	2	6	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:10569334C>T	uc001qyf.2	-	5	564	c.519G>A	c.(517-519)TGG>TGA	p.W173*	KLRC3_uc001qyh.2_Nonsense_Mutation_p.W173*|KLRC3_uc001qyi.1_Nonsense_Mutation_p.W173*	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	173	C-type lectin.|Extracellular (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						ACACACCAATCCATGAGGAAG	0.289													25	41					0	0	0	0	T	10569334	T	T	10569334	4	4	176	1	0	0	0	0	0	1	0	0	8456	856	30	2	311	2	KLRC3	12	10569334	Nonsense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1479462	10569334	123282561	273	33119											
TAS2R43	259289	broad.mit.edu	37	chr12	11244286	11244286	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagggtactaagtttgctacCatggttacagtcatatttga	12	14	9	6	0	1	1	1	1	0	0	1	1	1	1	1	2	4	4	1	2	6	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:11244286C>T	uc001qzq.1	-	1	627	c.543G>A	c.(541-543)ATG>ATA	p.M181I	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176884	NP_795365	P59537	T2R43_HUMAN	taste receptor, type 2, member 43	181	Helical; Name=5; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	cilium membrane|motile cilium	bitter taste receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		AGTTTGCTACCATGGTTACAG	0.368													59	50					0	0	0	0	T	11244286	T	T	11244286	3	4	176	1	0	0	0	0	1	0	0	0	15647	594	21	4	390	4	TAS2R43	12	11244286	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	674952	11244286	122607609	274	33120											
PRB1	5542	broad.mit.edu	37	chr12	11506661	11506661	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaccttgaggtctgttgcCtccttgtgggggtggtcctt	2	14	16	9	0	1	1	0	1	1	0	3	2	3	2	4	5	1	1	4	5	0	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:11506661C>T	uc001qzw.1	-	3	413	c.376G>A	c.(376-378)GGC>AGC	p.G126S	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	187	7.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGTCTGTTGCCTCCTTGTGGG	0.602													139	415					0	0	0	0	T	11506661	T	T	11506661	3	4	176	1	0	0	0	0	1	0	0	0	12504	681	24	4	623	4	PRB1	12	11506661	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	262375	11506661	122345234	275	33121											
PRB1	5542	broad.mit.edu	37	chr12	11506794	11506795	+	Missense_Mutation	DNP	GG	TT	TT																															cgggacttgtccccttgtggGggtggtccttgtggctttcc																								rs142774972		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:11506794_11506795GG>TT	uc001qzw.1	-	3	279_280	c.242_243CC>AA	c.(241-243)CCC>CAA	p.P81Q	PRB1_uc001qzu.1_Missense_Mutation_p.P81Q|PRB1_uc001qzv.1_Missense_Mutation_p.P81Q	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	142	5.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).|Missing (in allele M).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			CCCCTTGTGGGGGTGGTCCTTG	0.629													158	365					0	0	0	0	TT	11506795	TT	TT	11506794	3	4	176	1	0	0	0	0	1	0	0	0	12504	1219	43	4	756	4	PRB1	12	11506794	Missense_Mutation	DNP	GG	TCGA-CV-5441-01A-01D-1512-08	133	11506794	122345101	276	33122											
ABCC9	10060	broad.mit.edu	37	chr12	21970133	21970133	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaatacccattgtgccttCatagttctctgactccatag	10	13	6	12	0	2	1	1	1	1	0	4	1	3	1	3	0	3	2	3	0	4	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:21970133C>A	uc001rfi.1	-	31	3900	c.3880G>T	c.(3880-3882)GAA>TAA	p.E1294*	ABCC9_uc001rfh.2_Nonsense_Mutation_p.E1294*|ABCC9_uc001rfj.1_Nonsense_Mutation_p.E1258*	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1294	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ATTGTGCCTTCATAGTTCTCT	0.378													75	204					1.42748e-55	2.2822e-55	1	0	A	21970133	A	A	21970133	4	1	176	1	0	0	0	0	0	1	0	0	59	835	29	2	943	2	ABCC9	12	21970133	Nonsense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	10463339	21970133	111881762	277	33123											
SYT10	341359	broad.mit.edu	37	chr12	33538213	33538213	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaaaacatgatttcacccAggtctatactttcctagaaa	14	11	7	9	0	2	2	1	1	1	1	3	3	3	3	2	2	2	0	2	2	6	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:33538213A>C	uc001rll.1	-	4	1388	c.1091T>G	c.(1090-1092)CTG>CGG	p.L364R	SYT10_uc009zju.1_Missense_Mutation_p.L174R	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	364	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GATTTCACCCAGGTCTATACT	0.398													15	40					0	0	0	0	C	33538213	C	C	33538213	3	2	176	1	0	0	0	0	1	0	0	0	15532	188	7	5	496	5	SYT10	12	33538213	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	11568080	33538213	100313682	278	33124											
MLL2	8085	broad.mit.edu	37	chr12	49420595	49420595	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacccacaggtccaggtccaGgttcagcagacgggcaggcc	9	4	13	15	1	1	1	1	0	0	1	3	1	3	1	4	5	1	3	4	5	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:49420595G>A	uc001rta.3	-	48	15154	c.15154C>T	c.(15154-15156)CTG>TTG	p.L5052L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5052					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCCAGGTCCAGGTTCAGCAGA	0.617			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			32	82					0	0	0	0	A	49420595	A	A	49420595	2	1	176	1	0	0	0	0	0	0	0	1	9674	991	35	4		4	MLL2	12	49420595	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	15882382	49420595	84431300	279	33125											
MLL2	8085	broad.mit.edu	37	chr12	49420606	49420606	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggtccaggttcagcagaCgggcaggcccatcagtggcc	8	5	14	14	1	2	1	2	0	0	1	3	1	3	1	4	5	1	3	4	5	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:49420606C>A	uc001rta.3	-	48	15143	c.15143G>T	c.(15142-15144)CGT>CTT	p.R5048L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5048					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTTCAGCAGACGGGCAGGCCC	0.617			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			32	83					1.49673e-21	2.08416e-21	1	0	A	49420606	A	A	49420606	3	1	176	1	0	0	0	0	1	0	0	0	9674	536	19	3	1498	3	MLL2	12	49420606	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	11	49420606	84431289	280	33126											
KRT72	140807	broad.mit.edu	37	chr12	52979793	52979793	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggcctttttggtggcacaGctgctccccgaggttttggc	4	12	14	11	1	0	0	0	0	0	0	1	2	1	0	3	5	2	4	3	5	0	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:52979793G>A	uc001sar.2	-	9	1595	c.1509C>T	c.(1507-1509)AGC>AGT	p.S503S	KRT72_uc001saq.2_Silent_p.S503S|KRT72_uc010sns.1_Silent_p.S461S|KRT72_uc010snt.1_Silent_p.S315S	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	503	Tail.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		TGGTGGCACAGCTGCTCCCCG	0.562													98	202					0	0	0	0	A	52979793	A	A	52979793	2	1	176	1	0	0	0	0	0	0	0	1	8524	962	34	4		4	KRT72	12	52979793	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3559187	52979793	80872102	281	33127											
NCKAP1L	3071	broad.mit.edu	37	chr12	54913116	54913116	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgatctgtctactttctGgtatgtcttggttcagagct	5	19	9	8	0	6	2	1	1	5	1	6	2	6	2	0	2	2	3	0	2	2	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:54913116G>T	uc001sgc.3	+	16	1704	c.1625G>T	c.(1624-1626)TGC>TTC	p.C542F	NCKAP1L_uc010sox.1_Missense_Mutation_p.C84F|NCKAP1L_uc010soy.1_Missense_Mutation_p.C492F	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	542					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TCTACTTTCTGGTATGTCTTG	0.368													49	104					1.5774e-09	1.83205e-09	1	0	T	54913116	T	T	54913116	3	4	176	1	0	0	0	0	1	0	0	0	10276	1362	47	4	1687	4	NCKAP1L	12	54913116	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1933323	54913116	78938779	282	33128											
SMARCC2	6601	broad.mit.edu	37	chr12	56566376	56566376	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccgcacctcctaccttggagGgaacattcttttttgtgtac	7	14	8	12	1	1	0	0	0	1	0	2	2	2	2	4	2	3	2	4	2	3	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:56566376G>A	uc001skb.2	-	18	1869	c.1763C>T	c.(1762-1764)CCC>CTC	p.P588L	SMARCC2_uc001skd.2_Missense_Mutation_p.P619L|SMARCC2_uc001ska.2_Missense_Mutation_p.P619L|SMARCC2_uc001skc.2_Missense_Mutation_p.P618L|SMARCC2_uc010sqf.1_Missense_Mutation_p.P508L	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	588					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TACCTTGGAGGGAACATTCTT	0.502													46	100					0	0	0	0	A	56566376	A	A	56566376	3	1	176	1	0	0	0	0	1	0	0	0	14840	1232	43	4	1925	4	SMARCC2	12	56566376	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1653260	56566376	77285519	283	33129											
DTX3	196403	broad.mit.edu	37	chr12	58001107	58001107	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctcttcctcctcgccttcGggaggaggcagaagagcagg	8	7	13	13	2	1	2	0	0	1	2	5	4	3	4	4	4	1	2	4	4	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:58001107G>T	uc001sow.1	+	5	798	c.461G>T	c.(460-462)CGG>CTG	p.R154L	DTX3_uc001sov.1_Missense_Mutation_p.R147L|DTX3_uc001sox.1_Missense_Mutation_p.R147L|DTX3_uc001soy.1_Missense_Mutation_p.R147L|GEFT_uc009zpy.2_5'Flank|GEFT_uc001soz.1_5'Flank	NM_178502	NP_848597	Q8N9I9	DTX3_HUMAN	deltex homolog 3	154					Notch signaling pathway	cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					cctcgccttcGGGAGGAGGCA	0.493													5	21					1.23904e-05	1.34837e-05	1	0	T	58001107	T	T	58001107	3	4	176	1	0	0	0	0	1	0	0	0	4817	1116	39	3	467	3	DTX3	12	58001107	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1434731	58001107	75850788	284	33130											
TRHDE	29953	broad.mit.edu	37	chr12	72955994	72955994	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcagccagaaatgatctctGgaatacattatcggaggtaa	14	10	10	7	1	1	2	0	1	1	1	3	4	1	4	1	3	3	2	1	3	5	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:72955994G>T	uc001sxa.2	+	8	1733	c.1703G>T	c.(1702-1704)TGG>TTG	p.W568L		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	568	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						AATGATCTCTGGAATACATTA	0.289													26	37					0.000227799	0.000241803	1	0	T	72955994	T	T	72955994	3	4	176	1	0	0	0	0	1	0	0	0	16546	1357	47	4	1733	4	TRHDE	12	72955994	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	14954887	72955994	60895901	285	33131											
CAPS2	84698	broad.mit.edu	37	chr12	75692714	75692714	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtcatgagtgaaaaagaacCcaatgagctctctgcaagca	15	7	10	9	0	2	4	1	3	1	1	3	4	2	4	1	1	4	3	1	1	5	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:75692714C>A	uc001sxk.3	-	11	1141	c.944G>T	c.(943-945)GGG>GTG	p.G315V	CAPS2_uc001sxm.3_Missense_Mutation_p.G83V|CAPS2_uc009zsa.2_Intron|CAPS2_uc001sxi.3_Intron|CAPS2_uc001sxj.3_Intron|CAPS2_uc001sxl.3_Missense_Mutation_p.G296V	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	315							calcium ion binding			ovary(2)	2						GAAAAAGAACCCAATGAGCTC	0.313													23	47					1.10513e-12	1.35333e-12	1	0	A	75692714	A	A	75692714	3	1	176	1	0	0	0	0	1	0	0	0	2650	623	22	4	761	4	CAPS2	12	75692714	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2736720	75692714	58159181	286	33132											
C12orf12	196477	broad.mit.edu	37	chr12	91347314	91347314	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtctaacagttaaagtcCtgtgccatgaacagggattc	12	11	10	8	0	1	1	0	1	1	0	3	3	2	2	2	1	3	1	2	1	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:91347314C>G	uc001tbj.2	-	1	1640	c.1206G>C	c.(1204-1206)CAG>CAC	p.Q402H		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	402										central_nervous_system(1)|pancreas(1)	2						AGTTAAAGTCCTGTGCCATGA	0.373													7	111					0	0	0	0	G	91347314	G	G	91347314	3	3	176	1	0	0	0	0	1	0	0	0	1682	680	24	4	18	4	C12orf12	12	91347314	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	15654600	91347314	42504581	287	33133											
PLEKHG7	440107	broad.mit.edu	37	chr12	93134644	93134644	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagatctttatgaatacaCtaagatatctgcaaactcat	17	12	4	8	0	3	3	1	1	2	2	3	3	3	3	0	0	3	1	0	0	7	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:93134644C>A	uc001tcj.2	+	3	249	c.19C>A	c.(19-21)CTA>ATA	p.L7I		NM_001004330	NP_001004330	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G	7	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1						TATGAATACACTAAGATATCT	0.313													26	53					2.27525e-19	3.08529e-19	1	0	A	93134644	A	A	93134644	3	1	176	1	0	0	0	0	1	0	0	0	12130	564	20	4	25	4	PLEKHG7	12	93134644	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1787330	93134644	40717251	288	33134											
ANO4	121601	broad.mit.edu	37	chr12	101365164	101365164	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagatatgcagaacaaatGaatgtaagaatgcctttcag	17	9	10	5	0	1	4	1	1	0	3	1	5	1	5	1	1	3	2	1	1	7	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:101365164G>A	uc010svm.1	+	6	1109	c.537G>A	c.(535-537)ATG>ATA	p.M179I	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.M144I|ANO4_uc001thx.2_Missense_Mutation_p.M179I	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	179	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						CAGAACAAATGAATGTAAGAA	0.368										HNSCC(74;0.22)			37	74					0	0	0	0	A	101365164	A	A	101365164	3	1	176	1	0	0	0	0	1	0	0	0	699	1290	45	2	446	2	ANO4	12	101365164	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	8230520	101365164	32486731	289	33135											
FOXN4	121643	broad.mit.edu	37	chr12	109723196	109723196	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcttgtcgatgcgggccaGgttcagagcccacaggcagc	8	7	13	13	2	2	1	1	0	1	1	3	2	2	1	2	3	3	2	2	3	0	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:109723196G>T	uc001toe.3	-	8	919	c.814C>A	c.(814-816)CTG>ATG	p.L272M	FOXN4_uc009zvg.2_Missense_Mutation_p.L69M|FOXN4_uc001tof.3_Missense_Mutation_p.L92M	NM_213596	NP_998761	Q96NZ1	FOXN4_HUMAN	forkhead box N4	272	Fork-head.				axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|lung(1)	2						ATGCGGGCCAGGTTCAGAGCC	0.607													16	31					0.00074312	0.000776081	1	0	T	109723196	T	T	109723196	3	4	176	1	0	0	0	0	1	0	0	0	6056	991	35	4	751	4	FOXN4	12	109723196	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	8358032	109723196	24128699	290	33136											
RASAL1	8437	broad.mit.edu	37	chr12	113543660	113543660	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcgaacaatggccgagggCgggaacagggccctggctgg	8	5	17	11	3	1	0	0	0	1	0	2	3	1	1	2	6	2	1	2	6	3	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:113543660C>A	uc001tum.1	-	17	1979	c.1686G>T	c.(1684-1686)CCG>CCT	p.P562P	RASAL1_uc010syp.1_Silent_p.P563P|RASAL1_uc001tul.2_Silent_p.P562P|RASAL1_uc001tun.1_Silent_p.P564P|RASAL1_uc010syq.1_Silent_p.P563P|RASAL1_uc001tuo.3_Silent_p.P563P	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	562					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						TGGCCGAGGGCGGGAACAGGG	0.622													31	99					1.61788e-16	2.06929e-16	1	0	A	113543660	A	A	113543660	2	1	176	1	0	0	0	0	0	0	0	1	13128	755	27	3		3	RASAL1	12	113543660	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	3820464	113543660	20308235	291	33137											
SLC15A4	121260	broad.mit.edu	37	chr12	129294620	129294620	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttacatgaatcaaacagactTtgtttagaagattgctgaaa	16	13	7	5	0	1	5	1	2	0	3	1	5	1	5	0	0	3	2	0	0	6	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:129294620T>C	uc001uhu.2	-	3	932	c.879A>G	c.(877-879)CAA>CAG	p.Q293Q	SLC15A4_uc001uhv.2_Intron	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	solute carrier family 15, member 4	293					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		CAAACAGACTTTGTTTAGAAG	0.393													46	93					0	0	0	0	C	129294620	C	C	129294620	2	2	176	1	0	0	0	0	0	0	0	1	14466	1838	64	5		5	SLC15A4	12	129294620	Silent	SNP	T	TCGA-CV-5441-01A-01D-1512-08	15750960	129294620	4557275	292	33138											
GLT1D1	144423	broad.mit.edu	37	chr12	129360582	129360582	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgccctggctcttcatctCtataggggaggcaggctttt	5	13	12	11	0	3	0	1	0	2	0	4	1	3	1	1	5	1	4	1	5	2	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:129360582C>G	uc010tbh.1	+	2	168	c.159C>G	c.(157-159)CTC>CTG	p.L53L	GLT1D1_uc001uhx.1_Silent_p.L64L|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	64					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		CTCTTCATCTCTATAGGGGAG	0.448													82	183					0	0	0	0	G	129360582	G	G	129360582	2	3	176	1	0	0	0	0	0	0	0	1	6502	900	32	2		2	GLT1D1	12	129360582	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	65962	129360582	4491313	293	33139											
TMEM132D	121256	broad.mit.edu	37	chr12	130185032	130185032	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctcgatggagaaaggcccGtagctggcattgaggacagg	10	7	16	8	2	0	2	0	1	0	1	1	5	0	3	1	5	2	4	1	5	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:130185032G>A	uc009zyl.1	-	2	619	c.291C>T	c.(289-291)TAC>TAT	p.Y97Y		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	97	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AGAAAGGCCCGTAGCTGGCAT	0.488													30	52					0	0	0	0	A	130185032	A	A	130185032	2	1	176	1	0	0	0	0	0	0	0	1	16113	1140	40	1		1	TMEM132D	12	130185032	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	824450	130185032	3666863	294	33140											
POLE	5426	broad.mit.edu	37	chr12	133212601	133212601	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaatggaaggtctccttTgaatggatgctgcagaggaa	13	9	14	5	0	1	3	0	1	1	2	2	7	1	6	1	4	2	2	1	4	4	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr12:133212601T>C	uc001uks.1	-	42	5732	c.5688A>G	c.(5686-5688)TCA>TCG	p.S1896S	POLE_uc001ukq.1_Silent_p.S106S|POLE_uc001ukr.1_Silent_p.S700S|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1896					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		AGGTCTCCTTTGAATGGATGC	0.428								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					25	57					0	0	0	0	C	133212601	C	C	133212601	2	2	176	1	0	0	0	0	0	0	0	1	12251	1799	63	5		5	POLE	12	133212601	Silent	SNP	T	TCGA-CV-5441-01A-01D-1512-08	3027569	133212601	639294	295	33141											
FAM123A	219287	broad.mit.edu	37	chr13	25744108	25744108	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcatagagcgcgtccccgctGtagctatcccgggggatgcc	6	8	13	14	4	1	1	1	0	0	1	3	2	3	2	4	2	3	3	4	2	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr13:25744108G>T	uc001uqb.2	-	1	1750	c.1650C>A	c.(1648-1650)TAC>TAA	p.Y550*	FAM123A_uc001uqa.2_Nonsense_Mutation_p.Y431*|FAM123A_uc001uqc.2_Nonsense_Mutation_p.Y431*	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	550										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CGTCCCCGCTGTAGCTATCCC	0.642													41	23					9.62906e-15	1.20771e-14	1	0	T	25744108	T	T	25744108	4	4	176	1	0	0	0	0	0	1	0	0	5450	1372	48	4	369	4	FAM123A	13	25744108	Nonsense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08		25744108	89425770	296	33142											
ATP8A2	51761	broad.mit.edu	37	chr13	26542750	26542750	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaaagacattgctggaggagGtgcaggagctggaaaccaag	15	5	15	6	0	0	1	0	0	0	1	0	5	0	5	1	5	4	3	1	5	4	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr13:26542750G>C	uc001uqk.2	+	35	3452	c.3310G>C	c.(3310-3312)GTG>CTG	p.V1104L	ATP8A2_uc010tdi.1_Missense_Mutation_p.V1039L|ATP8A2_uc010tdj.1_RNA	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	1064	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GCTGGAGGAGGTGCAGGAGCT	0.522													6	11					0	0	0	0	C	26542750	C	C	26542750	3	2	176	1	0	0	0	0	1	0	0	0	1195	1261	44	4	3448	4	ATP8A2	13	26542750	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	798642	26542750	88627128	297	33143											
KBTBD6	89890	broad.mit.edu	37	chr13	41706215	41706215	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagcatgtcggaggccgcgtAcaggcgctccacgttggcct	6	8	14	13	5	0	0	0	0	0	0	2	1	1	1	3	4	2	4	3	4	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr13:41706215A>T	uc001uxu.1	-	1	722	c.433T>A	c.(433-435)TAC>AAC	p.Y145N	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.Y79N|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	145							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		GAGGCCGCGTACAGGCGCTCC	0.597													35	40					0	0	0	0	T	41706215	T	T	41706215	3	4	176	1	0	0	0	0	1	0	0	0	8036	391	14	5	1595	5	KBTBD6	13	41706215	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	15163465	41706215	73463663	298	33144											
PCDH17	27253	broad.mit.edu	37	chr13	58208987	58208987	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacaaaaatgatatcatgctGgtgcagagcgaagtggagga	16	7	13	5	1	1	2	1	1	0	1	1	5	1	4	0	3	4	2	0	3	5	1	rs77228191	by1000genomes	TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr13:58208987G>T	uc001vhq.1	+	1	3199	c.2307G>T	c.(2305-2307)CTG>CTT	p.L769L	PCDH17_uc010aec.1_Silent_p.L769L	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	769	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATATCATGCTGGTGCAGAGCG	0.572													19	25					8.00594e-06	8.82357e-06	1	0	T	58208987	T	T	58208987	2	4	176	1	0	0	0	0	0	0	0	1	11566	1335	47	4		4	PCDH17	13	58208987	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	16502772	58208987	56960891	299	33145											
KLHL1	57626	broad.mit.edu	37	chr13	70549883	70549883	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgatagaattcttcagagctActggagtccaaatcactttg	12	13	8	8	0	3	3	2	1	1	2	4	4	4	4	1	1	2	1	1	1	4	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr13:70549883A>G	uc001vip.2	-	2	1343	c.549T>C	c.(547-549)AGT>AGC	p.S183S	KLHL1_uc010thm.1_Intron	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	183					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CTTCAGAGCTACTGGAGTCCA	0.343													45	54					0	0	0	0	G	70549883	G	G	70549883	2	3	176	1	0	0	0	0	0	0	0	1	8404	388	14	5		5	KLHL1	13	70549883	Silent	SNP	A	TCGA-CV-5441-01A-01D-1512-08	12340896	70549883	44619995	300	33146											
NALCN	259232	broad.mit.edu	37	chr13	101910914	101910914	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aacatgtggaaaacggatgaCcgcatcattttctgaggggg	12	9	13	7	2	2	2	1	2	1	0	2	4	2	4	1	4	2	1	1	4	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr13:101910914C>T	uc001vox.1	-	11	1335	c.1146G>A	c.(1144-1146)CGG>CGA	p.R382R	NALCN_uc001voy.2_Silent_p.R97R|NALCN_uc001voz.2_Silent_p.R382R|NALCN_uc001vpa.2_Silent_p.R382R	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	382	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AAACGGATGACCGCATCATTT	0.463													12	20					0	0	0	0	T	101910914	T	T	101910914	2	4	176	1	0	0	0	0	0	0	0	1	10201	494	18	4		4	NALCN	13	101910914	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	31361031	101910914	13258964	301	33147											
MMP14	4323	broad.mit.edu	37	chr14	23313040	23313040	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgtgacgggaactttgaCaccgtggccatgctccgagg	8	9	13	11	3	1	2	0	2	1	0	2	4	2	3	3	3	2	1	3	3	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:23313040C>T	uc001whc.2	+	6	1206	c.972C>T	c.(970-972)GAC>GAT	p.D324D		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	324	Hemopexin-like 1.|Extracellular (Potential).					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		GGAACTTTGACACCGTGGCCA	0.493													51	153					0	0	0	0	T	23313040	T	T	23313040	2	4	176	1	0	0	0	0	0	0	0	1	9706	477	17	4		4	MMP14	14	23313040	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08		23313040	84036500	302	33148											
NYNRIN	57523	broad.mit.edu	37	chr14	24884816	24884816	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaccgcctgctcaccccCgcggcctccatgcctcgctt	5	7	9	20	4	1	1	1	0	0	1	3	2	2	1	7	1	3	2	7	1	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:24884816C>G	uc001wpf.3	+	9	4179	c.3861C>G	c.(3859-3861)CCC>CCG	p.P1287P		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1287					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						TGCTCACCCCCGCGGCCTCCA	0.622													38	89					0	0	0	0	G	24884816	G	G	24884816	2	3	176	1	0	0	0	0	0	0	0	1	10850	639	23	3		3	NYNRIN	14	24884816	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1571776	24884816	82464724	303	33149											
PRKD1	5587	broad.mit.edu	37	chr14	30066892	30066892	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcaggagccaggtaagcggGggtacccaccactgacctcc	9	5	12	15	1	1	1	1	1	0	0	2	2	2	2	5	4	3	2	5	4	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:30066892G>T	uc001wqh.2	-	16	2420	c.2239C>A	c.(2239-2241)CCC>ACC	p.P747T		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	747	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		AGGTAAGCGGGGGTACCCACC	0.493													39	84					7.05121e-23	9.95239e-23	1	0	T	30066892	T	T	30066892	3	4	176	1	0	0	0	0	1	0	0	0	12580	1232	43	4	511	4	PRKD1	14	30066892	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	5182076	30066892	77282648	304	33150											
NPAS3	64067	broad.mit.edu	37	chr14	34269516	34269516	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcatctggaactaccCgcccaaccgggagatctcca	11	5	9	16	2	2	1	0	0	2	1	3	3	2	2	4	2	5	2	4	2	3	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:34269516C>A	uc001wru.2	+	12	2067	c.2003C>A	c.(2002-2004)CCG>CAG	p.P668Q	NPAS3_uc001wrs.2_Missense_Mutation_p.P655Q|NPAS3_uc001wrt.2_Missense_Mutation_p.P636Q|NPAS3_uc001wrv.2_Missense_Mutation_p.P638Q	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	668					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		TGGAACTACCCGCCCAACCGG	0.622													29	85					2.85442e-18	3.75276e-18	1	0	A	34269516	A	A	34269516	3	1	176	1	0	0	0	0	1	0	0	0	10618	652	23	3	2104	3	NPAS3	14	34269516	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	4202624	34269516	73080024	305	33151											
MDGA2	161357	broad.mit.edu	37	chr14	47530772	47530772	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgtgatccaaaatcgtcctTtttttaatgctacaacataa	13	15	5	8	1	0	1	0	1	0	0	3	1	2	1	2	0	3	1	2	0	6	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:47530772T>A	uc001wwj.3	-	7	1194	c.998A>T	c.(997-999)AAA>ATA	p.K333I	MDGA2_uc001wwi.3_Missense_Mutation_p.K104I|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	333					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						AAATCGTCCTTTTTTTAATGC	0.348													12	35					0	0	0	0	A	47530772	A	A	47530772	3	1	176	1	0	0	0	0	1	0	0	0	9460	1841	64	5	1916	5	MDGA2	14	47530772	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	13261256	47530772	59818768	306	33152											
WDHD1	11169	broad.mit.edu	37	chr14	55448358	55448358	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tataggagtccacgtattacCaagtcctctgttaagcattc	11	13	7	10	1	1	0	0	0	1	0	4	1	3	1	3	1	2	3	3	1	6	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:55448358C>A	uc001xbm.1	-	16	2041	c.1963G>T	c.(1963-1965)GGT>TGT	p.G655C	WDHD1_uc010aom.1_Missense_Mutation_p.G172C|WDHD1_uc001xbn.1_Missense_Mutation_p.G532C	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	655						cytoplasm|nucleoplasm	DNA binding			skin(1)	1						CACGTATTACCAAGTCCTCTG	0.413													25	68					3.28513e-13	4.04203e-13	1	0	A	55448358	A	A	55448358	3	1	176	1	0	0	0	0	1	0	0	0	17339	594	21	4	1470	4	WDHD1	14	55448358	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	7917586	55448358	51901182	307	33153											
MTHFD1	4522	broad.mit.edu	37	chr14	64891613	64891613	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatcactcctgttcctggCggcgtagggcccatgacagt	6	11	11	13	2	2	1	2	1	0	0	4	1	4	1	3	3	0	2	3	3	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:64891613C>T	uc001xhb.2	+	9	1206	c.819C>T	c.(817-819)GGC>GGT	p.G273G	MTHFD1_uc010aqe.2_Silent_p.G309G|MTHFD1_uc010aqf.2_Silent_p.G329G	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	273	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.|Substrate binding.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CTGTTCCTGGCGGCGTAGGGC	0.458													20	56					0	0	0	0	T	64891613	T	T	64891613	2	4	176	1	0	0	0	0	0	0	0	1	9980	755	27	1		1	MTHFD1	14	64891613	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	9443255	64891613	42457927	308	33154											
SLC8A3	6547	broad.mit.edu	37	chr14	70633591	70633591	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggtaactgtggccacacAaggggaggctaggacagccc	11	5	15	10	0	0	0	0	0	0	0	0	3	0	2	2	6	2	2	2	6	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:70633591A>G	uc001xly.2	-	2	2303	c.1549T>C	c.(1549-1551)TGT>CGT	p.C517R	SLC8A3_uc001xlw.2_Missense_Mutation_p.C517R|SLC8A3_uc001xlx.2_Missense_Mutation_p.C517R|SLC8A3_uc001xlz.2_Missense_Mutation_p.C517R|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	517	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GTGGCCACACAAGGGGAGGCT	0.502													27	65					0	0	0	0	G	70633591	G	G	70633591	3	3	176	1	0	0	0	0	1	0	0	0	14772	130	5	5	1373	5	SLC8A3	14	70633591	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	5741978	70633591	36715949	309	33155											
SIPA1L1	26037	broad.mit.edu	37	chr14	72200507	72200507	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttggattggtccaacctggtAgatgctgccaaagcctatga	10	11	11	9	0	0	2	0	1	0	1	1	3	1	3	4	3	4	2	4	3	4	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:72200507A>G	uc001xms.2	+	19	5397	c.5049A>G	c.(5047-5049)GTA>GTG	p.V1683V	SIPA1L1_uc001xmt.2_Silent_p.V1662V|SIPA1L1_uc001xmu.2_Silent_p.V1662V|SIPA1L1_uc001xmv.2_Silent_p.V1683V|SIPA1L1_uc010ttm.1_Silent_p.V1137V|SIPA1L1_uc001xmw.2_Silent_p.V448V	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1683					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CCAACCTGGTAGATGCTGCCA	0.587													21	42					0	0	0	0	G	72200507	G	G	72200507	2	3	176	1	0	0	0	0	0	0	0	1	14394	407	15	5		5	SIPA1L1	14	72200507	Silent	SNP	A	TCGA-CV-5441-01A-01D-1512-08	1566916	72200507	35149033	310	33156											
KIAA0317	9870	broad.mit.edu	37	chr14	75150018	75150018	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaggttgaaaaattttgtaGtagggactatatgccacatt	13	13	9	6	0	0	1	0	1	0	0	0	2	0	2	2	2	1	3	2	2	6	8			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:75150018G>A	uc001xqb.2	-	5	967	c.462C>T	c.(460-462)TAC>TAT	p.Y154Y	KIAA0317_uc010tut.1_5'UTR|KIAA0317_uc001xqc.2_Silent_p.Y154Y|KIAA0317_uc001xqd.1_RNA	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	154	Filamin.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		AAATTTTGTAGTAGGGACTAT	0.274													30	78					0	0	0	0	A	75150018	A	A	75150018	2	1	176	1	0	0	0	0	0	0	0	1	8206	1024	36	4		4	KIAA0317	14	75150018	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2949511	75150018	32199522	311	33157											
C14orf174	161394	broad.mit.edu	37	chr14	77845409	77845409	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaattgggatccagaggaaGttgcagagtggattagccag	12	10	14	5	0	0	2	0	0	0	2	1	5	1	5	2	3	2	2	2	3	3	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:77845409G>A	uc001xtq.1	+	1	1648	c.1648G>A	c.(1648-1650)GTT>ATT	p.V550I	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	550	SAM.										0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		TCCAGAGGAAGTTGCAGAGTG	0.428													33	76					0	0	0	0	A	77845409	A	A	77845409	3	1	176	1	0	0	0	0	1	0	0	0	1765	1029	36	4	1650	4	C14orf174	14	77845409	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2695391	77845409	29504131	312	33158											
KIAA1409	57578	broad.mit.edu	37	chr14	94100936	94100936	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagttaatgaagcggcagcTggagcatcagtctagcgccc	10	7	12	12	2	2	1	1	1	1	0	2	2	2	2	2	2	4	4	2	2	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:94100936T>A	uc001ybv.1	+	30	5404	c.5321T>A	c.(5320-5322)CTG>CAG	p.L1774Q	KIAA1409_uc001ybs.1_Missense_Mutation_p.L1752Q	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1929						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AAGCGGCAGCTGGAGCATCAG	0.468													33	82					0	0	0	0	A	94100936	A	A	94100936	3	1	176	1	0	0	0	0	1	0	0	0	8269	1580	55	5	5369	5	KIAA1409	14	94100936	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	16255527	94100936	13248604	313	33159											
KIAA0284	283638	broad.mit.edu	37	chr14	105353169	105353169	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgccccagcctttctcCggcaagagagcttcactaag	8	8	9	16	1	2	1	1	0	1	1	3	2	2	1	5	1	3	2	5	1	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:105353169C>T	uc010axb.2	+	12	2817	c.2593C>T	c.(2593-2595)CGG>TGG	p.R865W	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.R795W|KIAA0284_uc001yps.2_Missense_Mutation_p.R771W|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	865						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		AGCCTTTCTCCGGCAAGAGAG	0.652													4	41					0	0	0	0	T	105353169	T	T	105353169	3	4	176	1	0	0	0	0	1	0	0	0	8205	643	23	1	2635	1	KIAA0284	14	105353169	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	11252233	105353169	1996371	314	33160											
AHNAK2	113146	broad.mit.edu	37	chr14	105411998	105411998	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agacacctccacgtcgggggCcgtcacatccatcttcgggc	7	7	11	16	4	2	1	1	0	1	1	6	1	4	1	4	3	0	0	4	3	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:105411998C>A	uc010axc.1	-	7	9910	c.9790G>T	c.(9790-9792)GCC>TCC	p.A3264S	AHNAK2_uc001ypx.2_Missense_Mutation_p.A3164S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3264						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACGTCGGGGGCCGTCACATCC	0.627													75	140					2.5377e-55	4.03229e-55	1	0	A	105411998	A	A	105411998	3	1	176	1	0	0	0	0	1	0	0	0	415	739	26	4	7601	4	AHNAK2	14	105411998	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	58829	105411998	1937542	315	33161											
AHNAK2	113146	broad.mit.edu	37	chr14	105412823	105412823	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgcctggggcagacacccCgaacgacggcatcttgaact	9	7	11	14	3	1	2	0	1	1	1	1	4	1	2	3	3	3	2	3	3	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr14:105412823C>G	uc010axc.1	-	7	9085	c.8965G>C	c.(8965-8967)GGG>CGG	p.G2989R	AHNAK2_uc001ypx.2_Missense_Mutation_p.G2889R	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2989						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCAGACACCCCGAACGACGGC	0.602													165	348					0	0	0	0	G	105412823	G	G	105412823	3	3	176	1	0	0	0	0	1	0	0	0	415	652	23	3	8426	3	AHNAK2	14	105412823	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	825	105412823	1936717	316	33162											
MKRN3	7681	broad.mit.edu	37	chr15	23811400	23811400	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccccgactcaggaagtggcGgaagcccccccggctgcatc	7	4	12	18	3	1	0	1	0	0	0	2	3	1	2	5	4	2	2	5	4	2	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:23811400G>A	uc001ywh.3	+	1	947	c.471G>A	c.(469-471)GCG>GCA	p.A157A	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Silent_p.A157A	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	157						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		AGGAAGTGGCGGAAGCCCCCC	0.642													17	60					0	0	0	0	A	23811400	A	A	23811400	2	1	176	1	0	0	0	0	0	0	0	1	9661	1103	39	1		1	MKRN3	15	23811400	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08		23811400	78719992	317	33163											
NDN	4692	broad.mit.edu	37	chr15	23932095	23932095	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgccggggctggcggtgcCgggcccggctgggccgcgct	0	5	21	15	7	0	0	0	0	0	0	0	0	0	0	4	7	2	3	4	7	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:23932095C>T	uc001ywk.2	-	1	356	c.270G>A	c.(268-270)CCG>CCA	p.P90P		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	90					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CTGGCGGTGCCGGGCCCGGCT	0.706									Prader-Willi_syndrome				16	31					0	0	0	0	T	23932095	T	T	23932095	2	4	176	1	0	0	0	0	0	0	0	1	10301	639	23	1		1	NDN	15	23932095	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	120695	23932095	78599297	318	33164											
TRPM1	4308	broad.mit.edu	37	chr15	31324988	31324988	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagatgatatccacacagtaGatcacccggccatagcccat	14	7	7	13	1	1	3	1	1	0	2	2	3	2	3	4	1	1	1	4	1	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:31324988G>A	uc001zfm.2	-	21	2918	c.2790C>T	c.(2788-2790)ATC>ATT	p.I930I	TRPM1_uc010azy.2_Silent_p.I837I|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	930	Helical; (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CCACACAGTAGATCACCCGGC	0.473													42	69					0	0	0	0	A	31324988	A	A	31324988	2	1	176	1	0	0	0	0	0	0	0	1	16652	932	33	2		2	TRPM1	15	31324988	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	7392893	31324988	71206404	319	33165											
SPRED1	161742	broad.mit.edu	37	chr15	38591587	38591587	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttagtaatagttatgcaCgagtgcgagctgtggtgatg	10	14	13	4	2	0	1	0	1	0	0	0	3	0	1	0	1	3	4	0	1	4	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:38591587C>T	uc001zka.3	+	2	381	c.46C>T	c.(46-48)CGA>TGA	p.R16*		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	16	WH1.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TAGTTATGCACGAGTGCGAGC	0.438									Legius_syndrome				30	62					0	0	0	0	T	38591587	T	T	38591587	4	4	176	1	0	0	0	0	0	1	0	0	15158	528	19	1	52	1	SPRED1	15	38591587	Nonsense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	7266599	38591587	63939805	320	33166											
SEMA6D	80031	broad.mit.edu	37	chr15	48055235	48055235	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccacactttcttcatgccatAgaatatggaaactatgtcta	13	13	5	10	0	3	1	1	0	2	1	3	2	3	2	2	1	2	0	2	1	6	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:48055235A>T	uc010bek.2	+	9	1041	c.681A>T	c.(679-681)ATA>ATT	p.I227I	SEMA6D_uc001zvw.2_Silent_p.I227I|SEMA6D_uc001zvx.1_Silent_p.I227I|SEMA6D_uc001zvy.2_Silent_p.I227I|SEMA6D_uc001zvz.2_Silent_p.I227I|SEMA6D_uc001zwa.2_Silent_p.I227I|SEMA6D_uc001zwb.2_Silent_p.I227I|SEMA6D_uc001zwc.2_Silent_p.I227I	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	227	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TTCATGCCATAGAATATGGAA	0.358													9	43					0	0	0	0	T	48055235	T	T	48055235	2	4	176	1	0	0	0	0	0	0	0	1	14107	410	15	5		5	SEMA6D	15	48055235	Silent	SNP	A	TCGA-CV-5441-01A-01D-1512-08	9463648	48055235	54476157	321	33167											
NARG2	79664	broad.mit.edu	37	chr15	60745949	60745949	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttcttttggggaagtggTgaattaatatatattacttt	11	20	8	2	0	1	1	0	1	1	0	1	2	1	2	0	3	1	0	0	3	7	10			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:60745949T>A	uc002agp.2	-	9	1213	c.978A>T	c.(976-978)TCA>TCT	p.S326S	NARG2_uc002ago.2_Silent_p.S189S|NARG2_uc002agq.3_5'UTR|NARG2_uc010bgk.2_Silent_p.S326S|NARG2_uc002agr.1_Silent_p.S326S	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	326						nucleus				ovary(1)|lung(1)	2						GGGGAAGTGGTGAATTAATAT	0.289													32	97					0	0	0	0	A	60745949	A	A	60745949	2	1	176	1	0	0	0	0	0	0	0	1	10222	1683	59	5		5	NARG2	15	60745949	Silent	SNP	T	TCGA-CV-5441-01A-01D-1512-08	12690714	60745949	41785443	322	33168											
VPS13C	54832	broad.mit.edu	37	chr15	62202492	62202492	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgacaaactttctggccAaaatggaaggcactaaaaat	16	8	8	9	0	1	1	0	1	1	0	1	2	1	2	2	3	1	1	2	3	7	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:62202492A>G	uc002agz.2	-	64	8802	c.8728T>C	c.(8728-8730)TGG>CGG	p.W2910R	VPS13C_uc002aha.2_Missense_Mutation_p.W2867R|VPS13C_uc002ahb.1_Missense_Mutation_p.W2910R|VPS13C_uc002ahc.1_Missense_Mutation_p.W2867R|VPS13C_uc002ahd.1_Missense_Mutation_p.W287R	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2910					protein localization					ovary(2)	2						CTTTCTGGCCAAAATGGAAGG	0.328													12	36					0	0	0	0	G	62202492	G	G	62202492	3	3	176	1	0	0	0	0	1	0	0	0	17259	130	5	5	2649	5	VPS13C	15	62202492	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	1456543	62202492	40328900	323	33169											
SMAD6	4091	broad.mit.edu	37	chr15	67073771	67073771	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcccctacgaccccaacagCgtccgcatcagcttcgccaa	9	5	8	19	4	1	0	1	0	0	0	3	1	2	0	6	1	4	2	6	1	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:67073771C>T	uc002aqf.2	+	4	2312	c.1389C>T	c.(1387-1389)AGC>AGT	p.S463S	SMAD6_uc010bhx.2_RNA|SMAD6_uc002aqg.2_Silent_p.S202S	NM_005585	NP_005576	O43541	SMAD6_HUMAN	SMAD family member 6 isoform 1	463	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			skin(1)	1						ACCCCAACAGCGTCCGCATCA	0.682													12	19					0	0	0	0	T	67073771	T	T	67073771	2	4	176	1	0	0	0	0	0	0	0	1	14826	767	27	1		1	SMAD6	15	67073771	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	4871279	67073771	35457621	324	33170											
CHRNA5	1138	broad.mit.edu	37	chr15	78878992	78878993	+	Frame_Shift_Ins	INS	-	A	A																															tttattttttaaaggatgagINSaaaaatcagttaatgacaac																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:78878992_78878993insA	uc002bdy.2	+	3	426_427	c.264_265insA	c.(262-267)GAGAAAfs	p.E88fs	CHRNA5_uc002bdz.2_Frame_Shift_Ins_p.E88fs	NM_000745	NP_000736	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5	88_89	Extracellular (Potential).				behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3						taaaGGATGAGAAAAATCAGTT	0.262													---	---	---								A	78878993	A	A	78878992	7	5	176	1	0	1	1	0	0	0	0	0	3401	933	33	0	274	0	CHRNA5	15	78878992	Frame_Shift_Ins	INS	-	TCGA-CV-5441-01A-01D-1512-08	11805221	78878992	23652400	325	33171											
POLG	5428	broad.mit.edu	37	chr15	89873428	89873428	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcaccagtagggacctccaGggggatgaggtcagccggcg	8	4	18	11	2	1	1	1	1	0	0	2	3	2	3	4	6	1	2	4	6	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:89873428G>A	uc002bns.3	-	3	1021	c.739C>T	c.(739-741)CTG>TTG	p.L247L	POLG_uc002bnr.3_Silent_p.L247L	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	247					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			GGGACCTCCAGGGGGATGAGG	0.612								DNA_polymerases_(catalytic_subunits)					9	80					0	0	0	0	A	89873428	A	A	89873428	2	1	176	1	0	0	0	0	0	0	0	1	12255	991	35	4		4	POLG	15	89873428	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	10994436	89873428	12657964	326	33172											
CHD2	1106	broad.mit.edu	37	chr15	93528831	93528831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgatgatgacaagaagcCaaagcgcagagggcgtccga	13	5	13	10	3	1	5	0	3	1	2	2	6	2	5	2	1	2	1	2	1	3	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr15:93528831C>T	uc002bsp.2	+	26	3916	c.3341C>T	c.(3340-3342)CCA>CTA	p.P1114L	CHD2_uc002bso.1_Missense_Mutation_p.P1114L	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1114					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GACAAGAAGCCAAAGCGCAGA	0.537													26	93					0	0	0	0	T	93528831	T	T	93528831	3	4	176	1	0	0	0	0	1	0	0	0	3340	594	21	4	3443	4	CHD2	15	93528831	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	3655403	93528831	9002561	327	33173											
ZNF597	146434	broad.mit.edu	37	chr16	3487215	3487215	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatcgctgaagttttggtCacactcaggacatttgtaca	11	13	9	8	1	2	2	2	2	0	0	3	3	2	3	0	2	1	3	0	2	2	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr16:3487215C>A	uc002cvd.2	-	4	668	c.484G>T	c.(484-486)GAC>TAC	p.D162Y		NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	zinc finger protein 597	162	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGTTTTGGTCACACTCAGGA	0.368													67	191					4.15811e-52	6.56677e-52	1	0	A	3487215	A	A	3487215	3	1	176	1	0	0	0	0	1	0	0	0	18094	826	29	2	794	2	ZNF597	16	3487215	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08		3487215	86867538	328	33174											
MYH11	4629	broad.mit.edu	37	chr16	15931989	15931989	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgcctcgaagccctgcttctCcgaggggacccagacgagtc	7	7	12	15	3	1	1	0	0	1	1	4	5	1	2	4	2	3	1	4	2	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr16:15931989C>G	uc002ddy.2	-	2	228	c.121G>C	c.(121-123)GAG>CAG	p.E41Q	MYH11_uc002ddv.2_Missense_Mutation_p.E41Q|MYH11_uc002ddw.2_Missense_Mutation_p.E41Q|MYH11_uc002ddx.2_Missense_Mutation_p.E41Q|MYH11_uc010bvg.2_5'UTR|MYH11_uc002deb.3_Missense_Mutation_p.E41Q	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	41	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CCCTGCTTCTCCGAGGGGACC	0.567			T	CBFB	AML								38	106					0	0	0	0	G	15931989	G	G	15931989	3	3	176	1	0	0	0	0	1	0	0	0	10084	864	30	2	6017	2	MYH11	16	15931989	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	12444774	15931989	74422764	329	33175											
ACSM2A	123876	broad.mit.edu	37	chr16	20487096	20487096	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cctatggccagacagaaacgGtacctgttcccaggggaacc	11	6	11	13	1	0	2	0	0	0	2	1	3	1	3	5	4	3	2	5	4	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr16:20487096G>T	uc010bwe.2	+	9	1337	c.1098_splice	c.e9+1	p.T366_splice	ACSM2A_uc010vax.1_Splice_Site_p.T287_splice|ACSM2A_uc002dhf.3_Splice_Site_p.T366_splice|ACSM2A_uc002dhg.3_Splice_Site_p.T366_splice|ACSM2A_uc010vay.1_Splice_Site_p.T287_splice|ACSM2A_uc002dhh.3_Splice_Site	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member						fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GACAGAAACGGTACCTGTTCC	0.473													95	233					2.37326e-55	3.78261e-55	1	0	T	20487096	T	T	20487096	5	4	176	1	0	0	0	0	0	0	1	0	183	1275	44	4	1125	4	ACSM2A	16	20487096	Splice_Site	SNP	G	TCGA-CV-5441-01A-01D-1512-08	4555107	20487096	69867657	330	33176											
PRKCB	5579	broad.mit.edu	37	chr16	24231346	24231346	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acagcctgtggaactgacccCcactgataaactcttcatca	12	9	6	14	0	3	2	2	2	1	0	3	3	3	3	3	1	3	0	3	1	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr16:24231346C>A	uc002dmd.2	+	17	2125	c.1928C>A	c.(1927-1929)CCC>CAC	p.P643H	PRKCB_uc002dme.2_3'UTR	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	643	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	GAACTGACCCCCACTGATAAA	0.423													28	51					4.59853e-10	5.40145e-10	1	0	A	24231346	A	A	24231346	3	1	176	1	0	0	0	0	1	0	0	0	12570	623	22	4	2157	4	PRKCB	16	24231346	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	3744250	24231346	66123407	331	33177											
SPNS1	83985	broad.mit.edu	37	chr16	28995109	28995109	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtctcctctccctgcagatCtctgaccgcctgcgccggaa	5	10	9	17	3	3	2	0	1	3	1	6	3	3	3	5	1	2	1	5	1	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr16:28995109C>T	uc010vdi.1	+	12	1463	c.1323C>T	c.(1321-1323)ATC>ATT	p.I441I	uc010vct.1_Intron|SPNS1_uc002drx.2_Silent_p.I368I|SPNS1_uc002dsa.2_Silent_p.I441I|SPNS1_uc002drz.2_Silent_p.I389I|SPNS1_uc010byp.2_Silent_p.I367I|SPNS1_uc010byq.1_Intron|LAT_uc010vdj.1_5'Flank|LAT_uc002dsb.2_5'Flank|LAT_uc002dsd.2_5'Flank|LAT_uc002dsc.2_5'Flank|LAT_uc010vdk.1_5'Flank|LAT_uc010vdl.1_5'Flank	NM_001142448	NP_001135920	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 isoform 1	441	Helical; (Potential).				lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding				0						CCCTGCAGATCTCTGACCGCC	0.637													57	91					0	0	0	0	T	28995109	T	T	28995109	2	4	176	1	0	0	0	0	0	0	0	1	15140	903	32	2		2	SPNS1	16	28995109	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	4763763	28995109	61359644	332	33178											
ZFP90	146198	broad.mit.edu	37	chr16	68598394	68598394	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttagtcaaagttcatctctCattcagcatgagagaactca	13	13	6	9	0	6	2	5	1	1	1	7	3	6	2	0	0	2	2	0	0	3	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr16:68598394C>T	uc010cff.2	+	5	1996	c.1704C>T	c.(1702-1704)CTC>CTT	p.L568L	ZFP90_uc002ewb.2_3'UTR|ZFP90_uc002ewc.2_3'UTR|ZFP90_uc002ewd.2_Silent_p.L568L|ZFP90_uc002ewe.2_Silent_p.L568L	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	568	C2H2-type 11.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		GTTCATCTCTCATTCAGCATG	0.438													53	119					0	0	0	0	T	68598394	T	T	68598394	2	4	176	1	0	0	0	0	0	0	0	1	17721	813	29	2		2	ZFP90	16	68598394	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	39603285	68598394	21756359	333	33179											
COG4	25839	broad.mit.edu	37	chr16	70530226	70530226	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttttgtgtcaaatttgccTtgctggaggctgctgtgcat	5	16	11	9	0	1	0	1	0	0	0	1	1	1	1	2	2	4	4	2	2	1	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr16:70530226T>A	uc002ezc.2	-	12	1601	c.1590A>T	c.(1588-1590)CAA>CAT	p.Q530H	COG4_uc002ezb.2_Missense_Mutation_p.Q7H|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.Q530H|COG4_uc002eze.2_Missense_Mutation_p.Q224H	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	526					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				CAAATTTGCCTTGCTGGAGGC	0.547													15	74					0	0	0	0	A	70530226	A	A	70530226	3	1	176	1	0	0	0	0	1	0	0	0	3675	1606	56	5	811	5	COG4	16	70530226	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	1931832	70530226	19824527	334	33180											
ADAT1	23536	broad.mit.edu	37	chr16	75646689	75646689	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctactgatgagttgtgggcCcaatttctgaagacaggaca	11	11	11	8	0	2	4	0	3	2	1	2	5	2	5	1	2	1	1	1	2	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr16:75646689C>A	uc002feo.1	-	7	597	c.495G>T	c.(493-495)TGG>TGT	p.W165C	ADAT1_uc002fep.1_Missense_Mutation_p.W16C	NM_012091	NP_036223	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	165	A to I editase.				tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			ovary(1)|skin(1)	2						AGTTGTGGGCCCAATTTCTGA	0.458													20	49					7.87624e-14	9.76051e-14	1	0	A	75646689	A	A	75646689	3	1	176	1	0	0	0	0	1	0	0	0	284	624	22	4	1033	4	ADAT1	16	75646689	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	5116463	75646689	14708064	335	33181											
ADAMTS18	170692	broad.mit.edu	37	chr16	77375634	77375634	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaacggtcccttctgctgcGggcataaacttggtctcaca	9	10	9	13	2	2	0	1	0	2	0	4	0	3	0	1	3	4	2	1	3	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr16:77375634G>C	uc002ffc.3	-	11	2096	c.1677C>G	c.(1675-1677)CCC>CCG	p.P559P	ADAMTS18_uc010chc.1_Silent_p.P147P|ADAMTS18_uc002ffe.1_Silent_p.P255P	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	559	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CTTCTGCTGCGGGCATAAACT	0.418													14	43					0	0	0	0	C	77375634	C	C	77375634	2	2	176	1	0	0	0	0	0	0	0	1	263	1103	39	3		3	ADAMTS18	16	77375634	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1728945	77375634	12979119	336	33182											
NECAB2	54550	broad.mit.edu	37	chr16	84024099	84024099	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcttctcttccttccacagGtatatgagggtgggagcaac	8	12	10	11	0	2	1	0	1	2	0	5	2	4	2	2	3	2	2	2	3	3	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr16:84024099G>T	uc002fhd.2	+	6	477	c.460G>T	c.(460-462)GTA>TTA	p.V154L	NECAB2_uc002fhe.2_Missense_Mutation_p.V71L	NM_019065	NP_061938	Q7Z6G3	NECA2_HUMAN	neuronal calcium-binding protein 2	154					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding			ovary(2)	2						CCTTCCACAGGTATATGAGGG	0.572													34	63					1.22384e-17	1.59684e-17	1	0	T	84024099	T	T	84024099	3	4	176	1	0	0	0	0	1	0	0	0	10359	1275	44	4	482	4	NECAB2	16	84024099	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	6648465	84024099	6330654	337	33183											
ZBTB4	57659	broad.mit.edu	37	chr17	7370091	7370091	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacggcgggggcatgggaCgggtccgtcacctctgcagg	6	5	19	11	4	2	0	1	0	1	0	3	2	3	2	2	7	1	2	2	7	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:7370091C>T	uc002ghc.3	-	3	280	c.30G>A	c.(28-30)CCG>CCA	p.P10P	ZBTB4_uc002ghd.3_Silent_p.P10P	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		GGGCATGGGACGGGTCCGTCA	0.657													2	0					0	0	0	0	T	7370091	T	T	7370091	2	4	176	1	0	0	0	0	0	0	0	1	17608	523	19	1		1	ZBTB4	17	7370091	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08		7370091	73825119	338	33184											
CHD3	1107	broad.mit.edu	37	chr17	7806008	7806008	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcatcgatggtggtatcacGggtgccctgaggcaggaggc	7	7	17	10	3	1	1	1	1	0	0	2	3	1	2	1	6	1	3	1	6	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:7806008G>A	uc002gje.2	+	21	3483	c.3333G>A	c.(3331-3333)ACG>ACA	p.T1111T	CHD3_uc002gjd.2_Silent_p.T1170T|CHD3_uc002gjf.2_Silent_p.T1111T|CHD3_uc002gjh.2_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1111	Helicase C-terminal.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GTGGTATCACGGGTGCCCTGA	0.507													96	49					0	0	0	0	A	7806008	A	A	7806008	2	1	176	1	0	0	0	0	0	0	0	1	3341	1103	39	1		1	CHD3	17	7806008	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	435917	7806008	73389202	339	33185											
ALOX15B	247	broad.mit.edu	37	chr17	7943265	7943265	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgtgctccagcaacagcGccaggaggagcttcaggccc	8	5	12	16	1	1	0	1	0	0	0	2	2	2	2	4	3	5	3	4	3	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:7943265G>T	uc002gju.2	+	3	529	c.413G>T	c.(412-414)CGC>CTC	p.R138L	ALOX15B_uc002gjv.2_Missense_Mutation_p.R138L|ALOX15B_uc002gjw.2_Missense_Mutation_p.R138L|ALOX15B_uc010vun.1_Missense_Mutation_p.R138L|ALOX15B_uc010cnp.2_5'UTR	NM_001141	NP_001132	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, second type	138	Lipoxygenase.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			ovary(1)	1						CAGCAACAGCGCCAGGAGGAG	0.612													46	46					6.60958e-23	9.35454e-23	1	0	T	7943265	T	T	7943265	3	4	176	1	0	0	0	0	1	0	0	0	539	1087	38	3	423	3	ALOX15B	17	7943265	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	137257	7943265	73251945	340	33186											
MYH8	4626	broad.mit.edu	37	chr17	10304007	10304007	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctcgctgatctcctccagTtcccgggagaggtcagagcg	6	9	12	14	3	3	3	1	1	2	2	7	4	5	3	3	2	1	2	3	2	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:10304007T>C	uc002gmm.2	-	27	3530	c.3435A>G	c.(3433-3435)GAA>GAG	p.E1145E	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1145	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TCTCCTCCAGTTCCCGGGAGA	0.592									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				98	44					0	0	0	0	C	10304007	C	C	10304007	2	2	176	1	0	0	0	0	0	0	0	1	10094	1722	60	5		5	MYH8	17	10304007	Silent	SNP	T	TCGA-CV-5441-01A-01D-1512-08	2360742	10304007	70891203	341	33187											
SSH2	85464	broad.mit.edu	37	chr17	27963640	27963640	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcatcttgtgggaccatatgTtccacaaagacaggaggtat	12	10	11	8	0	1	1	0	0	1	1	2	3	2	3	2	3	0	3	2	3	3	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:27963640T>C	uc002heo.1	-	14	1527	c.1527A>G	c.(1525-1527)GAA>GAG	p.E509E	SSH2_uc010wbh.1_Silent_p.E536E	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	509					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						GGACCATATGTTCCACAAAGA	0.463													38	159					0	0	0	0	C	27963640	C	C	27963640	2	2	176	1	0	0	0	0	0	0	0	1	15251	1722	60	5		5	SSH2	17	27963640	Silent	SNP	T	TCGA-CV-5441-01A-01D-1512-08	17659633	27963640	53231570	342	33188											
EFCAB5	374786	broad.mit.edu	37	chr17	28380818	28380818	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagagagtctattgcagaaCaagatcgacacaaagggtca	16	6	11	8	1	2	3	1	0	1	3	3	5	2	3	0	1	2	2	0	1	4	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:28380818C>A	uc002het.2	+	10	2038	c.1846C>A	c.(1846-1848)CAA>AAA	p.Q616K	EFCAB5_uc010wbi.1_Missense_Mutation_p.Q359K|EFCAB5_uc010wbj.1_Missense_Mutation_p.Q560K|EFCAB5_uc010wbk.1_Missense_Mutation_p.Q273K|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Missense_Mutation_p.Q495K|EFCAB5_uc010csf.2_Missense_Mutation_p.Q495K	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	616							calcium ion binding			ovary(1)|skin(1)	2						TATTGCAGAACAAGATCGACA	0.468													43	130					1.22674e-20	1.69454e-20	1	0	A	28380818	A	A	28380818	3	1	176	1	0	0	0	0	1	0	0	0	4960	479	17	4	1884	4	EFCAB5	17	28380818	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	417178	28380818	52814392	343	33189											
ACACA	31	broad.mit.edu	37	chr17	35549233	35549233	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctccagatgacgatagataCgatcctcctcaaactgagta	13	9	8	11	2	1	4	1	2	0	2	4	6	4	4	3	0	2	2	3	0	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:35549233C>T	uc002hnm.2	-	37	4294	c.4103G>A	c.(4102-4104)CGT>CAT	p.R1368H	ACACA_uc002hnk.2_Missense_Mutation_p.R1290H|ACACA_uc002hnl.2_Missense_Mutation_p.R1310H|ACACA_uc002hnn.2_Missense_Mutation_p.R1368H|ACACA_uc002hno.2_Missense_Mutation_p.R1405H|ACACA_uc010cuy.2_Missense_Mutation_p.R62H	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1368					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ACGATAGATACGATCCTCCTC	0.408													22	39					0	0	0	0	T	35549233	T	T	35549233	3	4	176	1	0	0	0	0	1	0	0	0	106	536	19	1	3017	1	ACACA	17	35549233	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	7168415	35549233	45645977	344	33190											
WNK4	65266	broad.mit.edu	37	chr17	40937377	40937377	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggacgacggcgagaagccGggcctcaagctctggctgcg	8	4	17	12	5	2	1	1	0	1	1	2	5	2	2	2	4	3	2	2	4	2	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:40937377G>T	uc002ibj.2	+	6	1374	c.1353G>T	c.(1351-1353)CCG>CCT	p.P451P	WNK4_uc010wgx.1_Silent_p.P115P|WNK4_uc002ibk.1_Silent_p.P223P|WNK4_uc010wgy.1_5'UTR	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	451					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GCGAGAAGCCGGGCCTCAAGC	0.602													7	16					0.000274275	0.000288769	1	0	T	40937377	T	T	40937377	2	4	176	1	0	0	0	0	0	0	0	1	17448	1103	39	3		3	WNK4	17	40937377	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	5388144	40937377	40257833	345	33191											
GPATCH8	23131	broad.mit.edu	37	chr17	42513913	42513913	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttggaatgggatctgttctcCctgtaacaggaacacataat	12	12	9	8	0	2	0	0	0	2	0	3	3	2	3	1	3	2	2	1	3	4	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:42513913C>A	uc002igw.1	-	4	258	c.194G>T	c.(193-195)GGG>GTG	p.G65V	GPATCH8_uc002igv.1_5'UTR|GPATCH8_uc010wiz.1_5'UTR	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	65	G-patch.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ATCTGTTCTCCCTGTAACAGG	0.428													28	73					5.77227e-19	7.72619e-19	1	0	A	42513913	A	A	42513913	3	1	176	1	0	0	0	0	1	0	0	0	6632	637	22	4	4334	4	GPATCH8	17	42513913	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1576536	42513913	38681297	346	33192											
TBKBP1	9755	broad.mit.edu	37	chr17	45785830	45785830	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcgggagttgagttccctaCaggggagaatcttgaggact	9	11	14	7	1	1	3	0	2	1	1	3	6	2	5	1	4	1	2	1	4	2	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:45785830C>A	uc002ilu.2	+	7	1792	c.943C>A	c.(943-945)CAG>AAG	p.Q315K		NM_014726	NP_055541	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	315					innate immune response						0						GAGTTCCCTACAGGGGAGAAT	0.652													17	41					3.32936e-07	3.77376e-07	1	0	A	45785830	A	A	45785830	3	1	176	1	0	0	0	0	1	0	0	0	15704	479	17	4	969	4	TBKBP1	17	45785830	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	3271917	45785830	35409380	347	33193											
AKAP1	8165	broad.mit.edu	37	chr17	55183669	55183669	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcacacagagctggcaaagGacgatgcggcgccagcaccc	11	3	12	15	3	1	1	1	0	0	1	1	3	1	2	2	3	3	3	2	3	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:55183669G>A	uc002iux.2	+	2	1075	c.844G>A	c.(844-846)GAC>AAC	p.D282N	AKAP1_uc010wnl.1_Missense_Mutation_p.D282N|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Missense_Mutation_p.D282N	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	282					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					GCTGGCAAAGGACGATGCGGC	0.577													52	111					0	0	0	0	A	55183669	A	A	55183669	3	1	176	1	0	0	0	0	1	0	0	0	445	1174	41	2	846	2	AKAP1	17	55183669	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	9397839	55183669	26011541	348	33194											
CCDC46	201134	broad.mit.edu	37	chr17	64059162	64059162	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatctggtcttctttagtCtctctgataacttgacagtc	8	16	7	10	0	5	2	0	2	5	0	7	2	5	2	0	1	1	1	0	1	3	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:64059162C>A	uc002jfl.2	-	11	1212	c.993G>T	c.(991-993)GAG>GAT	p.E331D	CCDC46_uc010deo.2_Missense_Mutation_p.E73D|CCDC46_uc002jfm.2_Missense_Mutation_p.E331D|CCDC46_uc010dep.2_Missense_Mutation_p.E289D	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	331	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			CTTCTTTAGTCTCTCTGATAA	0.323													30	66					2.4375e-19	3.29667e-19	1	0	A	64059162	A	A	64059162	3	1	176	1	0	0	0	0	1	0	0	0	2830	912	32	2	2108	2	CCDC46	17	64059162	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	8875493	64059162	17136048	349	33195											
ABCA9	10350	broad.mit.edu	37	chr17	67025355	67025355	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttccctgcatattctttttTaagatttttgattctgaaaa	10	20	4	7	0	2	3	0	2	2	1	3	3	3	3	1	0	1	1	1	0	4	9			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:67025355T>C	uc002jhu.2	-	11	1602	c.1459A>G	c.(1459-1461)AAA>GAA	p.K487E	ABCA9_uc010dez.2_Missense_Mutation_p.K487E	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	487	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TATTCTTTTTTAAGATTTTTG	0.328													23	36					0	0	0	0	C	67025355	C	C	67025355	3	2	176	1	0	0	0	0	1	0	0	0	39	1763	61	5	3531	5	ABCA9	17	67025355	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	2966193	67025355	14169855	350	33196											
CBX8	57332	broad.mit.edu	37	chr17	77768668	77768668	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccccccccagagctggggggGcctgagccatgtcggacccg	5	4	15	17	2	0	2	0	1	0	1	1	3	0	3	7	4	2	1	7	4	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr17:77768668G>T	uc002jxd.1	-	5	1029	c.936C>A	c.(934-936)GGC>GGA	p.G312G		NM_020649	NP_065700	Q9HC52	CBX8_HUMAN	chromobox homolog 8	312					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			AGCTGGGGGGGCCTGAGCCAT	0.692													15	24					1.49906e-05	1.62791e-05	1	0	T	77768668	T	T	77768668	2	4	176	1	0	0	0	0	0	0	0	1	2736	1203	42	4		4	CBX8	17	77768668	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	10743313	77768668	3426542	351	33197											
COLEC12	81035	broad.mit.edu	37	chr18	346445	346445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagagaaacagaatccaaacGgatgttggccagggtattat	15	8	12	6	1	0	2	0	0	0	2	1	5	1	3	2	3	2	2	2	3	5	3	rs140549407		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr18:346445G>A	uc002kkm.2	-	5	1392	c.1177C>T	c.(1177-1179)CGT>TGT	p.R393C		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	393	Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GAATCCAAACGGATGTTGGCC	0.433													202	76					0	0	0	0	A	346445	A	A	346445	3	1	176	1	0	0	0	0	1	0	0	0	3727	1116	39	1	1075	1	COLEC12	18	346445	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08		346445	77730803	352	33198											
EPB41L3	23136	broad.mit.edu	37	chr18	5397093	5397093	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttccaaagtttctgaaatGtggatggctgcactctgctc	8	14	10	9	0	2	1	0	1	2	0	4	2	3	2	1	2	2	5	1	2	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr18:5397093G>T	uc002kmt.1	-	18	2891	c.2805C>A	c.(2803-2805)CAC>CAA	p.H935Q	EPB41L3_uc010wzh.1_Missense_Mutation_p.H766Q|EPB41L3_uc002kmu.1_Missense_Mutation_p.H713Q|EPB41L3_uc010dkq.1_Missense_Mutation_p.H604Q|EPB41L3_uc002kms.1_Missense_Mutation_p.H170Q|EPB41L3_uc010wze.1_Missense_Mutation_p.H240Q|EPB41L3_uc010wzf.1_Missense_Mutation_p.H232Q|EPB41L3_uc010wzg.1_Missense_Mutation_p.H207Q|EPB41L3_uc010dkr.2_Missense_Mutation_p.H327Q	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	935	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TTTCTGAAATGTGGATGGCTG	0.438													221	96					1.58895e-58	2.54823e-58	1	0	T	5397093	T	T	5397093	3	4	176	1	0	0	0	0	1	0	0	0	5178	1368	48	4	478	4	EPB41L3	18	5397093	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	5050648	5397093	72680155	353	33199											
LAMA1	284217	broad.mit.edu	37	chr18	7037668	7037668	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgatgctgacctgatggCgcccgcctagtgcatcttgc	5	12	12	12	2	1	3	0	3	1	0	1	3	1	3	3	1	3	3	3	1	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr18:7037668C>T	uc002knm.2	-	12	1740	c.1646G>A	c.(1645-1647)CGC>CAC	p.R549H	LAMA1_uc010wzj.1_Missense_Mutation_p.R25H	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	549	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding	p.R549C(1)		ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GACCTGATGGCGCCCGCCTAG	0.547													180	73					0	0	0	0	T	7037668	T	T	7037668	3	4	176	1	0	0	0	0	1	0	0	0	8645	768	27	1	7789	1	LAMA1	18	7037668	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1640575	7037668	71039580	354	33200											
CEP192	55125	broad.mit.edu	37	chr18	13053023	13053023	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggggtgagcaggctgacGtatgtgtctgaaccagagag	9	8	17	7	1	1	4	0	3	1	1	1	5	1	4	1	3	2	4	1	3	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr18:13053023G>T	uc010xac.1	+	18	3203	c.3123G>T	c.(3121-3123)ACG>ACT	p.T1041T	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Silent_p.T566T|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'Flank|CEP192_uc002krs.1_Silent_p.T782T	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1041										ovary(4)|pancreas(1)	5						GCAGGCTGACGTATGTGTCTG	0.562													83	457					1.45872e-26	2.11066e-26	1	0	T	13053023	T	T	13053023	2	4	176	1	0	0	0	0	0	0	0	1	3266	1132	40	3		3	CEP192	18	13053023	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	6015355	13053023	65024225	355	33201											
MAPK4	5596	broad.mit.edu	37	chr18	48248423	48248423	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgtcagcagcacctgggaGgtgaagaggcctctgcgcaa	9	8	14	10	1	2	2	1	1	1	1	2	3	2	3	2	3	3	3	2	3	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr18:48248423G>C	uc002lev.2	+	4	1807	c.807G>C	c.(805-807)GAG>GAC	p.E269D	MAPK4_uc010xdm.1_Missense_Mutation_p.E58D|MAPK4_uc010doz.2_Intron	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	269	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GCACCTGGGAGGTGAAGAGGC	0.582													10	20					0	0	0	0	C	48248423	C	C	48248423	3	2	176	1	0	0	0	0	1	0	0	0	9333	991	35	4	817	4	MAPK4	18	48248423	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	35195400	48248423	29828825	356	33202											
C18orf22	79863	broad.mit.edu	37	chr18	77794529	77794529	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcgggctgtggcgctccCgcgcgggtctccgggccctg	0	6	19	16	7	1	0	0	0	1	0	3	0	2	0	3	5	0	2	3	5	0	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr18:77794529C>T	uc002lns.2	+	1	172	c.34C>T	c.(34-36)CGC>TGC	p.R12C	TXNL4A_uc010drg.2_5'Flank|C18orf22_uc010drh.2_Missense_Mutation_p.R12C|C18orf22_uc010dri.1_RNA	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	12					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		GTGGCGCTCCCGCGCGGGTCT	0.716													12	11					0	0	0	0	T	77794529	T	T	77794529	3	4	176	1	0	0	0	0	1	0	0	0	1907	652	23	1	36	1	C18orf22	18	77794529	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	29546106	77794529	282719	357	33203											
WDR18	57418	broad.mit.edu	37	chr19	990234	990234	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccgctcagcgtgctgcaggCcgacccctccaggattccgg	5	6	12	18	4	1	0	1	0	0	0	3	2	3	1	6	3	3	3	6	3	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:990234C>A	uc002lqm.1	+	4	493	c.467C>A	c.(466-468)GCC>GAC	p.A156D	WDR18_uc002lqn.1_RNA|WDR18_uc010drx.1_Missense_Mutation_p.A119D|WDR18_uc010dry.1_Missense_Mutation_p.A156D	NM_024100	NP_077005	Q9BV38	WDR18_HUMAN	WD repeat domain 18	156	WD 3.									skin(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCTGCAGGCCGACCCCTCC	0.721													8	30					1.12685e-05	1.23145e-05	1	0	A	990234	A	A	990234	3	1	176	1	0	0	0	0	1	0	0	0	17346	739	26	4	481	4	WDR18	19	990234	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08		990234	58138749	358	33204											
GPX4	2879	broad.mit.edu	37	chr19	1105707	1105707	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcgccgcgggctacaacgtCaaattcgatatgttcagcaa	11	10	9	11	5	2	0	2	0	0	0	4	1	2	0	1	1	3	3	1	1	5	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:1105707C>G	uc010xgg.1	+	5	482	c.375C>G	c.(373-375)GTC>GTG	p.V125V	GPX4_uc010xgh.1_Silent_p.V125V|GPX4_uc010xgi.1_Silent_p.V162V	NM_002085	NP_002076	P36969	GPX4_HUMAN	glutathione peroxidase 4 isoform A precursor	125					multicellular organismal development|phospholipid metabolic process		glutathione peroxidase activity|phospholipid-hydroperoxide glutathione peroxidase activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glutathione(DB00143)	GCTACAACGTCAAATTCGATA	0.587													8	15					0	0	0	0	G	1105707	G	G	1105707	2	3	176	1	0	0	0	0	0	0	0	1	6781	813	29	2		2	GPX4	19	1105707	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	115473	1105707	58023276	359	33205											
ARRDC5	645432	broad.mit.edu	37	chr19	4891219	4891219	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaccagctcgtagcgagtgtGcatgatctcaccgtcctgcg	7	9	12	13	4	1	1	1	1	1	0	4	3	2	1	3	0	4	3	3	0	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:4891219G>C	uc002mbm.2	-	3	868	c.868C>G	c.(868-870)CAC>GAC	p.H290D		NM_001080523	NP_001073992	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	290					signal transduction						0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		TAGCGAGTGTGCATGATCTCA	0.612													68	159					0	0	0	0	C	4891219	C	C	4891219	3	2	176	1	0	0	0	0	1	0	0	0	988	1319	46	4	164	4	ARRDC5	19	4891219	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3785512	4891219	54237764	360	33206											
PPAN-P2RY11	692312	broad.mit.edu	37	chr19	10221172	10221172	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttggctcagtgagcaagacgGaggaggagctgcaggccatc	10	6	16	9	1	1	2	1	1	0	1	2	5	1	5	1	5	3	4	1	5	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:10221172G>A	uc002mna.2	+	10	913	c.913G>A	c.(913-915)GAG>AAG	p.E305K	PPAN-P2RY11_uc010xla.1_Missense_Mutation_p.E305K|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Missense_Mutation_p.E305K|PPAN_uc002mnb.1_Missense_Mutation_p.E252K	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	305					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GAGCAAGACGGAGGAGGAGCT	0.657													6	19					0	0	0	0	A	10221172	A	A	10221172	3	1	176	1	0	0	0	0	1	0	0	0	12344	1175	41	2	951	2	PPAN-P2RY11	19	10221172	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	5329953	10221172	48907811	361	33207											
C19orf39	126074	broad.mit.edu	37	chr19	11486219	11486219	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtacccaccctcaaccCgagagcttttccggctcctg	7	9	7	18	2	1	1	1	0	0	1	4	2	4	1	6	1	3	3	6	1	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:11486219C>G	uc002mrg.1	+	2	254	c.217C>G	c.(217-219)CGA>GGA	p.R73G		NM_175871	NP_787067	Q6NVH7	CS039_HUMAN	hypothetical protein LOC126074	73											0						ACCCTCAACCCGAGAGCTTTT	0.592													72	182					0	0	0	0	G	11486219	G	G	11486219	3	3	176	1	0	0	0	0	1	0	0	0	1931	644	23	3	223	3	C19orf39	19	11486219	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1265047	11486219	47642764	362	33208											
RFX1	5989	broad.mit.edu	37	chr19	14074050	14074050	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggaaggaaccgaagctggCggcgctgcgcagggtcaggt	8	5	19	9	4	1	0	1	0	0	0	1	3	1	2	1	6	3	3	1	6	3	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:14074050C>A	uc002mxv.2	-	19	2880	c.2608G>T	c.(2608-2610)GCC>TCC	p.A870S		NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	870	Necessary for dimerization.				immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CCGAAGCTGGCGGCGCTGCGC	0.672													12	30					1.05317e-09	1.2287e-09	1	0	A	14074050	A	A	14074050	3	1	176	1	0	0	0	0	1	0	0	0	13327	768	27	3	343	3	RFX1	19	14074050	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2587831	14074050	45054933	363	33209											
OR10H5	284433	broad.mit.edu	37	chr19	15905710	15905710	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctacacggtcctcacaccCttcctcagccccatcatctt	8	10	3	20	1	4	0	3	0	1	0	6	0	6	0	6	1	2	0	6	1	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:15905710C>A	uc010xos.1	+	1	852	c.852C>A	c.(850-852)CCC>CCA	p.P284P		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCCTCACACCCTTCCTCAGCC	0.527													22	44					4.47668e-21	6.20032e-21	1	0	A	15905710	A	A	15905710	2	1	176	1	0	0	0	0	0	0	0	1	10963	668	24	4		4	OR10H5	19	15905710	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1831660	15905710	43223273	364	33210											
CYP4F2	8529	broad.mit.edu	37	chr19	15989674	15989674	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggtgtggtcaggcaggacGcggaagcgcagcagcgtgag	8	5	19	9	5	1	1	1	1	0	0	2	3	1	3	0	5	3	3	0	5	1	0	rs150488576	byFrequency	TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:15989674G>A	uc002nbs.1	-	13	1520	c.1470C>T	c.(1468-1470)CGC>CGT	p.R490R	CYP4F2_uc010xot.1_Silent_p.R341R	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	490					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CAGGCAGGACGCGGAAGCGCA	0.672													12	52					0	0	0	0	A	15989674	A	A	15989674	2	1	176	1	0	0	0	0	0	0	0	1	4205	1074	38	1		1	CYP4F2	19	15989674	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	83964	15989674	43139309	365	33211											
NWD1	284434	broad.mit.edu	37	chr19	16861004	16861004	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaaggaggacgctgagcccGgtgcacacagatttgctctg	9	7	14	11	2	1	2	0	1	1	1	1	4	1	4	1	3	3	4	1	3	1	1	rs148902093		TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:16861004G>A	uc002neu.3	+	6	1973	c.1551G>A	c.(1549-1551)CCG>CCA	p.P517P	NWD1_uc002net.3_Silent_p.P382P|NWD1_uc002nev.3_Silent_p.P311P			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	517	NACHT.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CGCTGAGCCCGGTGCACACAG	0.632													29	73					0	0	0	0	A	16861004	A	A	16861004	2	1	176	1	0	0	0	0	0	0	0	1	10835	1103	39	1		1	NWD1	19	16861004	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	871330	16861004	42267979	366	33212											
PGLS	25796	broad.mit.edu	37	chr19	17631872	17631872	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcctgaccgtgcccttcgaGaagcattccactttgtagct	7	12	8	14	2	0	2	0	1	0	1	3	3	2	2	4	0	3	3	4	0	2	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:17631872G>A	uc002ngw.2	+	5	809	c.759G>A	c.(757-759)GAG>GAA	p.E253E	FAM129C_uc010xpq.1_5'Flank|FAM129C_uc010xpr.1_5'Flank	NM_012088	NP_036220	O95336	6PGL_HUMAN	6-phosphogluconolactonase	253						cytosol	6-phosphogluconolactonase activity				0						TGCCCTTCGAGAAGCATTCCA	0.701													5	11					0	0	0	0	A	17631872	A	A	17631872	2	1	176	1	0	0	0	0	0	0	0	1	11847	933	33	2		2	PGLS	19	17631872	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	770868	17631872	41497111	367	33213											
ZNF257	113835	broad.mit.edu	37	chr19	22271667	22271667	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatactaaagagaaaccctAcaaatgtgaagagtgtggaa	18	8	9	6	0	1	3	1	1	0	2	1	5	1	4	1	1	3	0	1	1	8	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:22271667A>T	uc010ecx.2	+	4	1284	c.1115A>T	c.(1114-1116)TAC>TTC	p.Y372F	ZNF257_uc010ecy.2_Missense_Mutation_p.Y340F	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	372	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				GAGAAACCCTACAAATGTGAA	0.383													12	38					0	0	0	0	T	22271667	T	T	22271667	3	4	176	1	0	0	0	0	1	0	0	0	17867	391	14	5	1129	5	ZNF257	19	22271667	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	4639795	22271667	36857316	368	33214											
ZNF98	148198	broad.mit.edu	37	chr19	22586259	22586259	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgctgtgcggtgtccaggCattgccactcctccagagag	6	10	12	13	1	1	1	0	0	1	1	4	2	4	1	4	2	3	2	4	2	0	1	rs138636054	by1000genomes	TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:22586259C>A	uc002nqt.2	-	2	208	c.86G>T	c.(85-87)TGC>TTC	p.C29F		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	29	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				GGTGTCCAGGCATTGCCACTC	0.413													29	99					4.74835e-14	5.89844e-14	1	0	A	22586259	A	A	22586259	3	1	176	1	0	0	0	0	1	0	0	0	18270	710	25	4	1644	4	ZNF98	19	22586259	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	314592	22586259	36542724	369	33215											
ZNF536	9745	broad.mit.edu	37	chr19	31025860	31025860	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcccgtactgtgggaaaacTttccggacatcccatcacct	9	10	8	14	2	1	0	1	0	0	0	3	2	3	2	4	2	3	1	4	2	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:31025860T>C	uc002nsu.1	+	3	2415	c.2277T>C	c.(2275-2277)ACT>ACC	p.T759T	ZNF536_uc010edd.1_Silent_p.T759T	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	759	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GTGGGAAAACTTTCCGGACAT	0.612													49	109					0	0	0	0	C	31025860	C	C	31025860	2	2	176	1	0	0	0	0	0	0	0	1	18041	1596	56	5		5	ZNF536	19	31025860	Silent	SNP	T	TCGA-CV-5441-01A-01D-1512-08	8439601	31025860	28103123	370	33216											
ZNF30	90075	broad.mit.edu	37	chr19	35435633	35435633	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attccttactgaacatcagcGggtacacactggtgagaaac	13	9	9	10	1	1	2	1	2	0	1	2	3	2	2	1	2	5	1	1	2	4	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:35435633G>A	uc010edp.1	+	5	2141	c.1763G>A	c.(1762-1764)CGG>CAG	p.R588Q	ZNF30_uc002nxf.2_Missense_Mutation_p.R507Q|ZNF30_uc010edq.1_Missense_Mutation_p.R589Q|ZNF30_uc010edr.1_Missense_Mutation_p.R589Q	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	588	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		GAACATCAGCGGGTACACACT	0.403													15	26					0	0	0	0	A	35435633	A	A	35435633	3	1	176	1	0	0	0	0	1	0	0	0	17897	1116	39	1	1780	1	ZNF30	19	35435633	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	4409773	35435633	23693350	371	33217											
NFKBID	84807	broad.mit.edu	37	chr19	36381394	36381394	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgttgctcttgatctccTgaggggaagggaatggcaga	8	12	14	7	0	3	3	0	2	3	1	4	5	3	5	1	4	1	3	1	4	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:36381394T>A	uc002oci.1	-	10	1181	c.607_splice	c.e10-1	p.E203_splice	NFKBID_uc002och.1_Splice_Site_p.E40_splice|NFKBID_uc002ocj.1_Splice_Site_p.E218_splice	NM_139239	NP_640332	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene						inflammatory response	nucleus					0						CTTGATCTCCTGAGGGGAAGG	0.572													49	87					0	0	0	0	A	36381394	A	A	36381394	5	1	176	1	0	0	0	0	0	0	1	0	10433	1594	55	5	348	5	NFKBID	19	36381394	Splice_Site	SNP	T	TCGA-CV-5441-01A-01D-1512-08	945761	36381394	22747589	372	33218											
SIPA1L3	23094	broad.mit.edu	37	chr19	38610472	38610472	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagaccacatcttcctacagGcgacagagggttctgtggag	10	8	13	10	1	2	2	0	0	2	2	3	5	3	3	2	3	1	1	2	3	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:38610472G>T	uc002ohk.2	+	9	3327	c.2818G>T	c.(2818-2820)GCG>TCG	p.A940S		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	940					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CTTCCTACAGGCGACAGAGGG	0.542													22	44					3.10358e-05	3.35627e-05	1	0	T	38610472	T	T	38610472	3	4	176	1	0	0	0	0	1	0	0	0	14396	1203	42	4	2844	4	SIPA1L3	19	38610472	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2229078	38610472	20518511	373	33219											
IL28A	282616	broad.mit.edu	37	chr19	39760161	39760161	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccatggctttggaggctgagCtggccctgacgctgaaggtt	6	10	15	10	1	0	3	0	3	0	0	0	4	0	4	2	5	1	5	2	5	1	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:39760161C>T	uc002oku.1	+	4	356	c.304C>T	c.(304-306)CTG>TTG	p.L102L		NM_172138	NP_742150	Q8IZJ0	IL28A_HUMAN	interleukin 28A precursor	102					response to virus	extracellular space	cytokine activity			ovary(1)|skin(1)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;5.39e-26)|all cancers(26;4.1e-23)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGAGGCTGAGCTGGCCCTGAC	0.438													16	42					0	0	0	0	T	39760161	T	T	39760161	2	4	176	1	0	0	0	0	0	0	0	1	7721	796	28	4		4	IL28A	19	39760161	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1149689	39760161	19368822	374	33220											
SERTAD1	29950	broad.mit.edu	37	chr19	40929371	40929371	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgccaccgctgtgtggccaGgatctagccaccaggagtcg	7	7	14	13	2	1	0	0	0	1	0	2	2	1	2	5	3	2	1	5	3	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:40929371G>A	uc002ont.3	-	2	242	c.83C>T	c.(82-84)CCT>CTT	p.P28L		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	28					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGTGTGGCCAGGATCTAGCCA	0.572													12	50					0	0	0	0	A	40929371	A	A	40929371	3	1	176	1	0	0	0	0	1	0	0	0	14185	1000	35	4	631	4	SERTAD1	19	40929371	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1169210	40929371	18199612	375	33221											
ERCC2	2068	broad.mit.edu	37	chr19	45872213	45872213	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatctctggcacagttcttGagcagtagatgagtttggtc	9	13	11	8	0	2	3	0	2	2	1	4	3	2	3	0	2	1	5	0	2	2	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:45872213G>T	uc002pbj.2	-	4	268	c.221C>A	c.(220-222)TCA>TAA	p.S74*	ERCC2_uc010ejz.2_Nonsense_Mutation_p.S74*|ERCC2_uc002pbk.2_Nonsense_Mutation_p.S50*|ERCC2_uc002pbl.3_Nonsense_Mutation_p.S50*|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	74	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CACAGTTCTTGAGCAGTAGAT	0.582			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				29	75					4.22769e-11	5.03436e-11	1	0	T	45872213	T	T	45872213	4	4	176	1	0	0	0	0	0	1	0	0	5237	1294	45	2	2198	2	ERCC2	19	45872213	Nonsense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	4942842	45872213	13256770	376	33222											
FOXA3	3171	broad.mit.edu	37	chr19	46376291	46376291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctactaccagggcctctattCccgctctttgcttaatgcat	7	14	6	14	1	2	0	0	0	2	0	3	0	3	0	3	1	4	3	3	1	4	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:46376291C>T	uc002pdr.2	+	2	1225	c.1028C>T	c.(1027-1029)TCC>TTC	p.S343F		NM_004497	NP_004488	P55318	FOXA3_HUMAN	forkhead box A3	343					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)	1		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		GGCCTCTATTCCCGCTCTTTG	0.582													10	18					0	0	0	0	T	46376291	T	T	46376291	3	4	176	1	0	0	0	0	1	0	0	0	6023	855	30	2	1034	2	FOXA3	19	46376291	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	504078	46376291	12752692	377	33223											
TRPM4	54795	broad.mit.edu	37	chr19	49684706	49684706	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaactctttcggggggaCatccaatggcgggtgagggg	8	8	18	7	2	1	2	0	2	1	0	3	3	2	3	1	7	1	0	1	7	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:49684706C>T	uc002pmw.2	+	10	1323	c.1251C>T	c.(1249-1251)GAC>GAT	p.D417D	TRPM4_uc010emu.2_Silent_p.D417D|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_Silent_p.D243D|TRPM4_uc010emv.2_Silent_p.D302D|TRPM4_uc010yal.1_Intron|TRPM4_uc002pmy.2_5'Flank	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	417	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TTCGGGGGGACATCCAATGGC	0.557													22	44					0	0	0	0	T	49684706	T	T	49684706	2	4	176	1	0	0	0	0	0	0	0	1	16655	477	17	4		4	TRPM4	19	49684706	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	3308415	49684706	9444277	378	33224											
POLD1	5424	broad.mit.edu	37	chr19	50919882	50919882	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcagggggggaccacacgcGctgcaagacggtgctcacgg	8	4	17	12	4	1	1	1	0	0	1	1	2	1	2	1	5	3	4	1	5	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:50919882G>A	uc002psb.3	+	24	3025	c.2969G>A	c.(2968-2970)CGC>CAC	p.R990H	POLD1_uc002psc.3_Missense_Mutation_p.R990H|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.R1016H|SPIB_uc002psd.2_5'Flank|SPIB_uc002pse.2_5'Flank|SPIB_uc010ycc.1_5'Flank	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	990					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		GACCACACGCGCTGCAAGACG	0.706								DNA_polymerases_(catalytic_subunits)					3	7					0	0	0	0	A	50919882	A	A	50919882	3	1	176	1	0	0	0	0	1	0	0	0	12245	1087	38	1	3059	1	POLD1	19	50919882	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1235176	50919882	8209101	379	33225											
ZNF616	90317	broad.mit.edu	37	chr19	52620044	52620044	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacatccccttgactatgttGatctcttttaccagtaagat	10	16	5	10	0	1	3	0	2	1	1	3	3	2	3	3	0	2	2	3	0	4	7			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:52620044G>T	uc002pym.2	-	4	656	c.373C>A	c.(373-375)CAA>AAA	p.Q125K	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TGACTATGTTGATCTCTTTTA	0.378													64	165					1.55088e-19	2.10855e-19	1	0	T	52620044	T	T	52620044	3	4	176	1	0	0	0	0	1	0	0	0	18108	1299	45	2	1976	2	ZNF616	19	52620044	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	1700162	52620044	6508939	380	33226											
CACNG6	59285	broad.mit.edu	37	chr19	54515364	54515364	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgatcctgctgttgggggCcggctgctttctgctgctca	2	13	13	13	1	2	1	1	1	1	0	3	1	3	1	3	3	4	6	3	3	0	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:54515364C>A	uc002qct.2	+	4	1294	c.704C>A	c.(703-705)GCC>GAC	p.A235D	CACNG6_uc002qcu.2_Missense_Mutation_p.A189D|CACNG6_uc002qcv.2_Missense_Mutation_p.A164D	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	235	Helical; (Potential).					voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		CTGTTGGGGGCCGGCTGCTTT	0.701													39	52					1.61572e-30	2.36425e-30	1	0	A	54515364	A	A	54515364	3	1	176	1	0	0	0	0	1	0	0	0	2573	739	26	4	718	4	CACNG6	19	54515364	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	1895320	54515364	4613619	381	33227											
LILRB1	10859	broad.mit.edu	37	chr19	55148089	55148089	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaggcggaagaggacaggCagatggacactgaggtgagt	13	4	18	6	1	0	4	0	2	0	2	0	8	0	7	0	6	0	1	0	6	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:55148089C>A	uc002qgj.2	+	15	2132	c.1792C>A	c.(1792-1794)CAG>AAG	p.Q598K	LILRB1_uc010erp.1_3'UTR|LILRB1_uc002qgl.2_Missense_Mutation_p.Q599K|LILRB1_uc002qgk.2_Missense_Mutation_p.Q599K|LILRB1_uc002qgm.2_Missense_Mutation_p.Q600K|LILRB1_uc010erq.2_Missense_Mutation_p.Q582K|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	598	Cytoplasmic (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		AGAGGACAGGCAGATGGACAC	0.612										HNSCC(37;0.09)			10	44					2.27111e-07	2.5799e-07	1	0	A	55148089	A	A	55148089	3	1	176	1	0	0	0	0	1	0	0	0	8831	711	25	4	1848	4	LILRB1	19	55148089	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	632725	55148089	3980894	382	33228											
ZNF579	163033	broad.mit.edu	37	chr19	56090061	56090061	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggccgtggacgcggcggtgCtggcggaggtaggaggcgag	5	4	24	8	6	0	0	0	0	0	0	0	4	0	3	1	9	1	2	1	9	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:56090061C>A	uc002qlh.2	-	2	998	c.945G>T	c.(943-945)CAG>CAT	p.Q315H		NM_152600	NP_689813	Q8NAF0	ZN579_HUMAN	zinc finger protein 579	315	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.106)		CGCGGCGGTGCTGGCGGAGGT	0.736													3	22					1.024e-07	1.16578e-07	1	0	A	56090061	A	A	56090061	3	1	176	1	0	0	0	0	1	0	0	0	18078	796	28	4	747	4	ZNF579	19	56090061	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	941972	56090061	3038922	383	33229											
ZSCAN5B	342933	broad.mit.edu	37	chr19	56703218	56703218	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accaaggcctcacacactcaCctgcctcctggacagtgcag	10	6	8	17	0	2	0	2	0	0	0	3	1	3	1	5	2	2	1	5	2	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:56703218C>A	uc010ygh.1	-	2	588	c.588_splice	c.e2+1	p.Q196_splice		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CACACACTCACCTGCCTCCTG	0.607													12	31					1.5739e-10	1.85713e-10	1	0	A	56703218	A	A	56703218	5	1	176	1	0	0	0	0	0	0	1	0	18306	521	18	4	910	4	ZSCAN5B	19	56703218	Splice_Site	SNP	C	TCGA-CV-5441-01A-01D-1512-08	613157	56703218	2425765	384	33230											
ZNF835	90485	broad.mit.edu	37	chr19	57176560	57176560	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagggcgacgctcaagagtcCctccatcctcgatccctggg	7	7	12	15	3	1	1	1	0	0	1	6	4	5	1	4	2	0	1	4	2	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr19:57176560C>A	uc010ygo.1	-	2	73	c.73G>T	c.(73-75)GGA>TGA	p.G25*	ZNF835_uc010ygn.1_Nonsense_Mutation_p.G3*	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CTCAAGAGTCCCTCCATCCTC	0.498													16	57					2.35188e-11	2.82662e-11	1	0	A	57176560	A	A	57176560	4	1	176	1	0	0	0	0	0	1	0	0	18253	632	22	4	1608	4	ZNF835	19	57176560	Nonsense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	473342	57176560	1952423	385	33231											
TGM3	7053	broad.mit.edu	37	chr20	2308958	2308958	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtacatcagcaccaaggCggtgggcagcaatgctcgca	11	5	13	12	2	1	0	1	0	0	0	2	0	1	0	1	4	4	6	1	4	3	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:2308958C>T	uc002wfx.3	+	9	1377	c.1280C>T	c.(1279-1281)GCG>GTG	p.A427V		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	427					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	AGCACCAAGGCGGTGGGCAGC	0.572													19	48					0	0	0	0	T	2308958	T	T	2308958	3	4	176	1	0	0	0	0	1	0	0	0	15897	768	27	1	1314	1	TGM3	20	2308958	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08		2308958	60716562	386	33232											
TGM6	343641	broad.mit.edu	37	chr20	2411213	2411213	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaagcttctggtggagaaGgacattactctagaggactt	12	10	13	6	0	2	3	0	0	2	3	2	7	2	5	0	4	2	1	0	4	4	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:2411213G>T	uc002wfy.1	+	11	1861	c.1800G>T	c.(1798-1800)AAG>AAT	p.K600N	TGM6_uc010gal.1_Missense_Mutation_p.K600N	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	600					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	TGGTGGAGAAGGACATTACTC	0.512													22	59					0.000175454	0.000187392	1	0	T	2411213	T	T	2411213	3	4	176	1	0	0	0	0	1	0	0	0	15900	991	35	4	1842	4	TGM6	20	2411213	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	102255	2411213	60614307	387	33233											
TMC2	117532	broad.mit.edu	37	chr20	2592857	2592857	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttgctaatgaagagacaatAaagaacatcactcactggac	17	8	7	9	0	2	3	2	1	0	2	2	5	2	4	0	1	2	1	0	1	6	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:2592857A>G	uc002wgf.1	+	13	1629	c.1614A>G	c.(1612-1614)ATA>ATG	p.I538M	TMC2_uc002wgg.1_Missense_Mutation_p.I522M|TMC2_uc010zpw.1_Missense_Mutation_p.I370M|TMC2_uc010zpx.1_Missense_Mutation_p.I369M	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	538	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						AAGAGACAATAAAGAACATCA	0.502													49	153					0	0	0	0	G	2592857	G	G	2592857	3	3	176	1	0	0	0	0	1	0	0	0	16051	352	13	5	1664	5	TMC2	20	2592857	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	181644	2592857	60432663	388	33234											
CDS2	8760	broad.mit.edu	37	chr20	5166473	5166473	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgtggtgtttggccttctgGtaggtggtggctttcagctg	2	16	16	7	0	2	0	1	0	1	0	2	0	2	0	1	6	1	4	1	6	1	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:5166473G>A	uc002wls.2	+	9	1085	c.828_splice	c.e9+1	p.L276_splice	CDS2_uc002wlr.1_Splice_Site_p.L198_splice|CDS2_uc010zqt.1_Splice_Site|CDS2_uc002wlu.2_Splice_Site_p.L221_splice|CDS2_uc010zqu.1_Splice_Site_p.L156_splice|CDS2_uc002wlv.2_Splice_Site_p.L178_splice|CDS2_uc010zqv.1_Splice_Site_p.L97_splice	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2						phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0						TGGCCTTCTGGTAGGTGGTGG	0.557													43	88					0	0	0	0	A	5166473	A	A	5166473	5	1	176	1	0	0	0	0	0	0	1	0	3193	1275	44	4	863	4	CDS2	20	5166473	Splice_Site	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2573616	5166473	57859047	389	33235											
PROKR2	128674	broad.mit.edu	37	chr20	5283103	5283103	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaccagagctcccgggaGatcctggcatagcacagggt	10	7	13	11	1	0	3	0	1	0	2	2	4	2	3	3	3	3	3	3	3	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:5283103G>T	uc010zqw.1	-	2	738	c.738C>A	c.(736-738)ATC>ATA	p.I246I	PROKR2_uc010zqx.1_Silent_p.I246I|PROKR2_uc010zqy.1_Silent_p.I246I	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	246	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GCTCCCGGGAGATCCTGGCAT	0.587										HNSCC(71;0.22)			34	66					9.17885e-22	1.28504e-21	1	0	T	5283103	T	T	5283103	2	4	176	1	0	0	0	0	0	0	0	1	12615	932	33	2		2	PROKR2	20	5283103	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	116630	5283103	57742417	390	33236											
HAO1	54363	broad.mit.edu	37	chr20	7866414	7866414	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccttggcgccaagagccAgagctttcagaacatcagtg	11	7	11	12	1	2	3	2	0	0	3	2	3	2	3	3	1	4	1	3	1	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:7866414A>C	uc002wmw.1	-	6	935	c.911T>G	c.(910-912)CTG>CGG	p.L304R	HAO1_uc010gbu.2_Missense_Mutation_p.L304R	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	304	FMN hydroxy acid dehydrogenase.|FMN (By similarity).				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						GCCAAGAGCCAGAGCTTTCAG	0.488													59	146					0	0	0	0	C	7866414	C	C	7866414	3	2	176	1	0	0	0	0	1	0	0	0	6990	188	7	5	213	5	HAO1	20	7866414	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	2583311	7866414	55159106	391	33237											
SEL1L2	80343	broad.mit.edu	37	chr20	13839934	13839934	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatgcctaagccgtgttcatAcatataagccagattgaaca	14	10	8	9	1	1	2	1	1	0	1	1	3	1	2	3	0	5	1	3	0	5	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:13839934A>G	uc010gcf.2	-	18	1874	c.1792T>C	c.(1792-1794)TAT>CAT	p.Y598H	SEL1L2_uc002woq.3_Missense_Mutation_p.Y459H|SEL1L2_uc010zrl.1_Intron|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	598	Extracellular (Potential).|Sel1-like 11.					integral to membrane	binding			ovary(2)	2						CCGTGTTCATACATATAAGCC	0.403													27	58					0	0	0	0	G	13839934	G	G	13839934	3	3	176	1	0	0	0	0	1	0	0	0	14076	391	14	5	286	5	SEL1L2	20	13839934	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	5973520	13839934	49185586	392	33238											
SSTR4	6754	broad.mit.edu	37	chr20	23017173	23017173	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactactatgccactgctctCaagagcaaaggtggggcagg	11	7	13	10	0	1	1	1	0	1	1	2	2	1	1	1	4	4	3	1	4	4	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:23017173C>A	uc002wsr.2	+	1	1117	c.1053C>A	c.(1051-1053)CTC>CTA	p.L351L		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	351	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCACTGCTCTCAAGAGCAAAG	0.652													39	59					9.45814e-24	1.34597e-23	1	0	A	23017173	A	A	23017173	2	1	176	1	0	0	0	0	0	0	0	1	15266	813	29	2		2	SSTR4	20	23017173	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	9177239	23017173	40008347	393	33239											
SSTR4	6754	broad.mit.edu	37	chr20	23017264	23017264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggccgcaagcgcatccccCtcaccaggaccaccaccttc	8	4	7	22	3	1	0	1	0	0	0	3	1	2	1	8	2	1	2	8	2	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:23017264C>T	uc002wsr.2	+	1	1208	c.1144C>T	c.(1144-1146)CTC>TTC	p.L382F		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	382	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCGCATCCCCCTCACCAGGAC	0.657													40	88					0	0	0	0	T	23017264	T	T	23017264	3	4	176	1	0	0	0	0	1	0	0	0	15266	681	24	4	1146	4	SSTR4	20	23017264	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	91	23017264	40008256	394	33240											
MAPRE1	22919	broad.mit.edu	37	chr20	31434486	31434486	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agggatttctacttcggaaaGctacggaacattgaattgat	13	12	10	6	2	1	2	0	2	1	0	2	5	1	5	0	3	4	1	0	3	5	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:31434486G>A	uc002wyh.2	+	6	799	c.660G>A	c.(658-660)AAG>AAA	p.K220K		NM_012325	NP_036457	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family,	220	Interaction with CDK5RAP2.|EB1 C-terminal.|APC-binding.|Interaction with MTUS2/TIP150.|DCTN1-binding.				cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding				0						ACTTCGGAAAGCTACGGAACA	0.423													69	163					0	0	0	0	A	31434486	A	A	31434486	2	1	176	1	0	0	0	0	0	0	0	1	9347	962	34	4		4	MAPRE1	20	31434486	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	8417222	31434486	31591034	395	33241											
C20orf186	149954	broad.mit.edu	37	chr20	31685548	31685548	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccactgccgaggtcatggtCtcccagcccaaagacctgga	9	6	11	15	1	2	1	1	0	1	1	3	3	2	2	5	3	2	0	5	3	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:31685548C>A	uc010zue.1	+	11	1539	c.1524C>A	c.(1522-1524)GTC>GTA	p.V508V		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	508						cytoplasm|extracellular region	lipid binding				0						AGGTCATGGTCTCCCAGCCCA	0.572													34	52					2.08457e-15	2.64658e-15	1	0	A	31685548	A	A	31685548	2	1	176	1	0	0	0	0	0	0	0	1	2108	900	32	2		2	C20orf186	20	31685548	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	251062	31685548	31339972	396	33242											
EPB41L1	2036	broad.mit.edu	37	chr20	34778267	34778267	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagccaagagactgtggaaGgtctgcatcgagcatcatac	12	8	11	10	1	3	1	2	0	1	1	4	4	3	2	1	2	4	2	1	2	3	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:34778267G>T	uc002xfb.2	+	10	1266	c.1095G>T	c.(1093-1095)AAG>AAT	p.K365N	EPB41L1_uc002xeu.2_Missense_Mutation_p.K303N|EPB41L1_uc010zvo.1_Missense_Mutation_p.K365N|EPB41L1_uc002xev.2_Missense_Mutation_p.K365N|EPB41L1_uc002xew.2_Missense_Mutation_p.K268N|EPB41L1_uc002xex.2_Missense_Mutation_p.K334N|EPB41L1_uc002xey.2_Missense_Mutation_p.K292N|EPB41L1_uc002xez.2_Missense_Mutation_p.K303N	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	365	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					GACTGTGGAAGGTCTGCATCG	0.542													9	28					0.000442599	0.000465044	1	0	T	34778267	T	T	34778267	3	4	176	1	0	0	0	0	1	0	0	0	5176	991	35	4	1129	4	EPB41L1	20	34778267	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3092719	34778267	28247253	397	33243											
PPP1R16B	26051	broad.mit.edu	37	chr20	37464725	37464725	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accgcaagcgaaagcatgagCggaagcgcagcacgggcggc	12	1	16	12	6	0	1	0	1	0	0	0	3	0	2	1	3	5	4	1	3	3	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:37464725C>A	uc002xje.2	+	2	346	c.157C>A	c.(157-159)CGG>AGG	p.R53R	PPP1R16B_uc010ggc.2_Silent_p.R53R	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	53	Potential.				regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				AAAGCATGAGCGGAAGCGCAG	0.677													13	22					4.3838e-07	4.9473e-07	1	0	A	37464725	A	A	37464725	2	1	176	1	0	0	0	0	0	0	0	1	12426	759	27	3		3	PPP1R16B	20	37464725	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2686458	37464725	25560795	398	33244											
PTPRT	11122	broad.mit.edu	37	chr20	41100930	41100930	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcctcagtctgcaccaccaGctcctcgctctccattcggc	5	11	6	19	2	3	0	1	0	2	0	8	0	5	0	5	1	2	3	5	1	0	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:41100930G>T	uc002xkg.2	-	8	1610	c.1426C>A	c.(1426-1428)CTG>ATG	p.L476M	PTPRT_uc010ggj.2_Missense_Mutation_p.L476M	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	476	Extracellular (Potential).|Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGCACCACCAGCTCCTCGCTC	0.582													43	83					5.73435e-26	8.25109e-26	1	0	T	41100930	T	T	41100930	3	4	176	1	0	0	0	0	1	0	0	0	12877	962	34	4	3056	4	PTPRT	20	41100930	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3636205	41100930	21924590	399	33245											
PTPRT	11122	broad.mit.edu	37	chr20	41419980	41419980	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaggcccctgggctggacCtgtcacggctggagaagtag	8	7	15	11	1	2	1	2	0	0	1	2	3	2	2	3	5	0	3	3	5	3	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr20:41419980C>A	uc002xkg.2	-	3	525	c.341G>T	c.(340-342)AGG>ATG	p.R114M	PTPRT_uc010ggj.2_Missense_Mutation_p.R114M	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	114	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGGCTGGACCTGTCACGGCT	0.602													27	69					9.78306e-22	1.36594e-21	1	0	A	41419980	A	A	41419980	3	1	176	1	0	0	0	0	1	0	0	0	12877	681	24	4	4161	4	PTPRT	20	41419980	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	319050	41419980	21605540	400	33246											
NCAM2	4685	broad.mit.edu	37	chr21	22849700	22849700	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctccagtggaccatggggtAtgaagttcagattacagctg	10	11	12	8	0	2	2	1	1	1	1	3	3	2	3	2	3	2	3	2	3	3	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr21:22849700A>G	uc002yld.1	+	15	2234	c.1985A>G	c.(1984-1986)TAT>TGT	p.Y662C	NCAM2_uc011acb.1_Missense_Mutation_p.Y520C	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	662	Fibronectin type-III 2.|Extracellular (Potential).			YEVQIT -> MKFRLP (in Ref. 1; AAB80803).	neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		ACCATGGGGTATGAAGTTCAG	0.403													34	49					0	0	0	0	G	22849700	G	G	22849700	3	3	176	1	0	0	0	0	1	0	0	0	10257	449	16	5	2043	5	NCAM2	21	22849700	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08		22849700	25280195	401	33247											
ADAMTS5	11096	broad.mit.edu	37	chr21	28306893	28306893	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttcttggtcagacagacCatctggccctggcgtaccac	8	9	10	14	1	3	2	1	0	2	2	3	2	3	2	3	3	2	2	3	3	1	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr21:28306893C>A	uc002ymg.2	-	4	2310	c.1581G>T	c.(1579-1581)ATG>ATT	p.M527I		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	527	Disintegrin.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TCAGACAGACCATCTGGCCCT	0.572													35	73					1.26612e-14	1.58418e-14	1	0	A	28306893	A	A	28306893	3	1	176	1	0	0	0	0	1	0	0	0	269	594	21	4	1231	4	ADAMTS5	21	28306893	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	5457193	28306893	19823002	402	33248											
BACH1	571	broad.mit.edu	37	chr21	30693704	30693704	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagaaagatgtgctgtgcGatgtcaccatctttgtggag	10	11	14	6	1	2	2	1	0	1	2	2	5	2	4	1	2	2	1	1	2	2	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr21:30693704G>T	uc002ynj.2	+	2	218	c.103G>T	c.(103-105)GAT>TAT	p.D35Y	BACH1_uc002ynk.2_Missense_Mutation_p.D35Y|BACH1_uc002ynl.2_RNA	NM_001186	NP_001177	O14867	BACH1_HUMAN	BTB and CNC homology 1 transcription factor	35	BTB.					nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|liver(1)	2						TGTGCTGTGCGATGTCACCAT	0.522													52	159					1.66251e-12	2.0263e-12	1	0	T	30693704	T	T	30693704	3	4	176	1	0	0	0	0	1	0	0	0	1285	1058	37	3	105	3	BACH1	21	30693704	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	2386811	30693704	17436191	403	33249											
KRTAP19-3	337970	broad.mit.edu	37	chr21	31864055	31864056	+	Missense_Mutation	DNP	CC	AA	AA																															agaatccagagaatccatatCctccatagtatgatgggcgg																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr21:31864055_31864056CC>AA	uc002yog.1	-	1	220_221	c.220_221GG>TT	c.(220-222)GGA>TTA	p.G74L		NM_181609	NP_853640	Q7Z4W3	KR193_HUMAN	keratin associated protein 19-3	74						intermediate filament					0						GAATCCATATCCTCCATAGTAT	0.47													68	145					0	0	0	0	AA	31864056	AA	AA	31864055	3	1	176	1	0	0	0	0	1	0	0	0	8569	855	30	2	28	2	KRTAP19-3	21	31864055	Missense_Mutation	DNP	CC	TCGA-CV-5441-01A-01D-1512-08	1170351	31864055	16265840	404	33250											
COL6A2	1292	broad.mit.edu	37	chr21	47537349	47537349	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcggacctcctggctgcaaGggagaccctggaaaccgggt	9	6	14	12	2	0	1	0	0	0	1	2	4	1	3	4	5	2	2	4	5	2	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr21:47537349G>A	uc002zia.1	+	11	1117	c.1035G>A	c.(1033-1035)AAG>AAA	p.K345K	COL6A2_uc002zhy.1_Silent_p.K345K|COL6A2_uc002zhz.1_Silent_p.K345K|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	345	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CTGGCTGCAAGGGAGACCCTG	0.672													15	44					0	0	0	0	A	47537349	A	A	47537349	2	1	176	1	0	0	0	0	0	0	0	1	3715	991	35	4		4	COL6A2	21	47537349	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	15673294	47537349	592546	405	33251											
ZNF280A	129025	broad.mit.edu	37	chr22	22868460	22868460	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cataccacttgatcctggctGaactgaagtttgaataataa	14	12	7	8	0	0	4	0	4	0	0	1	4	1	4	2	1	2	2	2	1	6	5			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr22:22868460G>A	uc002zwe.2	-	2	1748	c.1495C>T	c.(1495-1497)CAG>TAG	p.Q499*	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	499					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GATCCTGGCTGAACTGAAGTT	0.328													47	99					0	0	0	0	A	22868460	A	A	22868460	4	1	176	1	0	0	0	0	0	1	0	0	17881	1299	45	2	137	2	ZNF280A	22	22868460	Nonsense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08		22868460	28436106	406	33252											
ZNF280A	129025	broad.mit.edu	37	chr22	22869368	22869368	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaagacatatctgaagggAccacagctaaagaaggtacc	17	6	10	8	0	1	4	0	1	1	3	1	5	1	5	2	2	2	2	2	2	8	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr22:22869368A>C	uc002zwe.2	-	2	840	c.587T>G	c.(586-588)GTC>GGC	p.V196G	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		ATCTGAAGGGACCACAGCTAA	0.438													18	182					0	0	0	0	C	22869368	C	C	22869368	3	2	176	1	0	0	0	0	1	0	0	0	17881	275	10	5	1045	5	ZNF280A	22	22869368	Missense_Mutation	SNP	A	TCGA-CV-5441-01A-01D-1512-08	908	22869368	28435198	407	33253											
TMPRSS6	164656	broad.mit.edu	37	chr22	37462243	37462243	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaggaaccagcggccactGagtgccttgcacaccagcgg	9	4	13	15	2	0	1	0	1	0	0	0	2	0	2	5	3	5	1	5	3	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr22:37462243G>A	uc003aqs.1	-	18	2427	c.2313C>T	c.(2311-2313)CTC>CTT	p.L771L	TMPRSS6_uc003aqt.1_Silent_p.L784L	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	771	Peptidase S1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						AGCGGCCACTGAGTGCCTTGC	0.622													12	28					0	0	0	0	A	37462243	A	A	37462243	2	1	176	1	0	0	0	0	0	0	0	1	16317	1277	45	2		2	TMPRSS6	22	37462243	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	14592875	37462243	13842323	408	33254											
RAC2	5880	broad.mit.edu	37	chr22	37627347	37627347	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttcagtttctcgatggtGtccttgtcgtcccgcaggtc	3	15	10	13	3	2	0	1	0	1	0	8	1	5	0	3	2	0	2	3	2	0	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr22:37627347G>T	uc003arc.2	-	5	489	c.372C>A	c.(370-372)GAC>GAA	p.D124E		NM_002872	NP_002863	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2	124					axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			breast(2)|central_nervous_system(1)|skin(1)	4						TCTCGATGGTGTCCTTGTCGT	0.637													35	54					4.65686e-17	6.03064e-17	1	0	T	37627347	T	T	37627347	3	4	176	1	0	0	0	0	1	0	0	0	13040	1368	48	4	214	4	RAC2	22	37627347	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	165104	37627347	13677219	409	33255											
ELFN2	114794	broad.mit.edu	37	chr22	37769436	37769436	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctcctcgtagtacagggcGggaaagctgtgccggtgctc	6	8	14	13	3	0	0	0	0	0	0	3	1	1	1	3	3	4	4	3	3	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr22:37769436G>A	uc003asq.3	-	3	2925	c.2139C>T	c.(2137-2139)CCC>CCT	p.P713P		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	713	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					AGTACAGGGCGGGAAAGCTGT	0.547													7	13					0	0	0	0	A	37769436	A	A	37769436	2	1	176	1	0	0	0	0	0	0	0	1	5082	1103	39	1		1	ELFN2	22	37769436	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	142089	37769436	13535130	410	33256											
SMCR7L	54471	broad.mit.edu	37	chr22	39907350	39907350	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggatgacaatggcattggCacggccattgactttgtgct	10	11	12	8	1	0	2	0	2	0	0	0	3	0	3	1	4	1	3	1	4	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr22:39907350C>A	uc003axx.2	+	3	549	c.51C>A	c.(49-51)GGC>GGA	p.G17G	SMCR7L_uc003axw.2_Silent_p.G17G|SMCR7L_uc010gxz.1_5'UTR|SMCR7L_uc003axy.2_5'UTR	NM_019008	NP_061881	Q9NQG6	SMC7L_HUMAN	hypothetical protein LOC54471	17						integral to membrane|mitochondrion				central_nervous_system(1)	1	Melanoma(58;0.04)					ATGGCATTGGCACGGCCATTG	0.587													13	39					2.61681e-11	3.13775e-11	1	0	A	39907350	A	A	39907350	2	1	176	1	0	0	0	0	0	0	0	1	14855	697	25	4		4	SMCR7L	22	39907350	Silent	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2137914	39907350	11397216	411	33257											
CELSR1	9620	broad.mit.edu	37	chr22	46930098	46930098	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcattgtcattaatgtcCaagatggtcacctggatttc	9	13	11	8	0	2	1	2	0	0	1	4	2	3	2	2	4	0	1	2	4	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr22:46930098C>A	uc003bhw.1	-	1	2970	c.2970G>T	c.(2968-2970)TTG>TTT	p.L990F		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	990	Extracellular (Potential).|Cadherin 7.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CATTAATGTCCAAGATGGTCA	0.547													46	90					8.04919e-23	1.13301e-22	1	0	A	46930098	A	A	46930098	3	1	176	1	0	0	0	0	1	0	0	0	3236	593	21	4	6214	4	CELSR1	22	46930098	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	7022748	46930098	4374468	412	33258											
ZBED4	9889	broad.mit.edu	37	chr22	50279075	50279075	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtggccggaccatcagccggGggaagaagccgactaacttg	10	5	15	11	3	1	1	1	0	0	1	1	4	1	3	4	4	3	0	4	4	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr22:50279075G>T	uc003bix.2	+	2	2235	c.1765G>T	c.(1765-1767)GGG>TGG	p.G589W		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	589	BED-type 4.					cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CATCAGCCGGGGGAAGAAGCC	0.517													38	75					2.45108e-15	3.08919e-15	1	0	T	50279075	T	T	50279075	3	4	176	1	0	0	0	0	1	0	0	0	17587	1232	43	4	1767	4	ZBED4	22	50279075	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	3348977	50279075	1025491	413	33259											
SBF1	6305	broad.mit.edu	37	chr22	50899572	50899589	+	Splice_Site	DEL	GCGCACCGCGCCCCACCT	-	-																															gggggatgagagccccacccGcgcaccgcgccccacctgga																								rs115010488	by1000genomes	TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr22:50899572_50899589delGCGCACCGCGCCCCACCT	uc003blh.2	-	23	3162	c.2967_splice	c.e23+1	p.Q989_splice	SBF1_uc011arx.1_Splice_Site_p.Q653_splice|SBF1_uc003bli.2_3'UTR	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1						protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		AGCCCCACCCGCGCACCGCGCCCCACCTGGAATGTGCA	0.624													---	---	---								-	50899589	-	-	50899572	8	5	176	1	0	1	0	1	0	0	1	0	13923	1102	38	0		0	SBF1	22	50899572	Splice_Site	DEL	GCGCACCGCGCCCCACCT	TCGA-CV-5441-01A-01D-1512-08	620497	50899572	404994	414	33260											
SHANK3	85358	broad.mit.edu	37	chr22	51143509	51143509	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaggaagccagaagaggacGgggctcggcgcagaggtgag	12	2	19	8	3	0	4	0	1	0	3	1	6	0	6	1	6	1	2	1	6	3	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chr22:51143509G>T	uc003bne.1	+	17	2062	c.2062G>T	c.(2062-2064)GGG>TGG	p.G688W	SHANK3_uc003bnf.1_Missense_Mutation_p.G143W	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	688										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		AGAAGAGGACGGGGCTCGGCG	0.587													21	62					1.2644e-06	1.42074e-06	1	0	T	51143509	T	T	51143509	3	4	176	1	0	0	0	0	1	0	0	0	14331	1116	39	3	2128	3	SHANK3	22	51143509	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	243937	51143509	161057	415	33261											
MSL3	10943	broad.mit.edu	37	chrX	11783734	11783734	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctctgaggcggtccacgCgccacagtgccaactgtgac	8	7	12	14	3	1	2	0	2	1	0	3	2	2	2	3	2	2	0	3	2	1	0			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:11783734C>A	uc004cuw.2	+	9	1162	c.1057C>A	c.(1057-1059)CGC>AGC	p.R353S	MSL3_uc004cuv.1_Missense_Mutation_p.R353S|MSL3_uc004cux.2_Missense_Mutation_p.R294S|MSL3_uc011mig.1_Missense_Mutation_p.R204S|MSL3_uc011mih.1_Missense_Mutation_p.R341S|MSL3_uc004cuy.2_Missense_Mutation_p.R187S	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	353					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCGGTCCACGCGCCACAGTGC	0.622													44	42					8.4772e-36	1.28774e-35	1	0	A	11783734	A	A	11783734	3	1	176	1	0	0	0	0	1	0	0	0	9932	768	27	3	1091	3	MSL3	23	11783734	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08		11783734	143486826	416	33262											
MAGEB2	4113	broad.mit.edu	37	chrX	30237175	30237175	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaagaaagcctctgagggcCtcagtgttgtctttggcctt	7	13	11	10	0	4	2	2	1	2	1	4	2	4	2	3	2	1	1	3	2	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:30237175C>A	uc004dbz.2	+	2	581	c.478C>A	c.(478-480)CTC>ATC	p.L160I		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	160	MAGE.						protein binding			ovary(1)	1						CTCTGAGGGCCTCAGTGTTGT	0.463													14	6					9.31168e-06	1.02409e-05	1	0	A	30237175	A	A	30237175	3	1	176	1	0	0	0	0	1	0	0	0	9229	681	24	4	480	4	MAGEB2	23	30237175	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	18453441	30237175	125033385	417	33263											
BCOR	54880	broad.mit.edu	37	chrX	39933957	39933957	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggccttgtacatgttcagTgaatacttatttggcgagtc	10	14	10	7	1	1	1	1	1	0	0	2	2	1	1	1	2	2	2	1	2	5	6			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:39933957T>A	uc004den.3	-	4	934	c.642A>T	c.(640-642)TCA>TCT	p.S214S	BCOR_uc004dep.3_Silent_p.S214S|BCOR_uc004deo.3_Silent_p.S214S|BCOR_uc004dem.3_Silent_p.S214S|BCOR_uc004deq.3_Silent_p.S214S	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	214					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						ACATGTTCAGTGAATACTTAT	0.542													55	22					0	0	0	0	A	39933957	A	A	39933957	2	1	176	1	0	0	0	0	0	0	0	1	1388	1683	59	5		5	BCOR	23	39933957	Silent	SNP	T	TCGA-CV-5441-01A-01D-1512-08	9696782	39933957	115336603	418	33264											
MED14	9282	broad.mit.edu	37	chrX	40513656	40513656	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgcaaacctcttcagaatGttgctgaccatcatgggagc	10	11	9	11	0	4	2	2	1	2	1	4	3	4	3	2	1	4	3	2	1	2	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:40513656G>A	uc004dex.3	-	30	4391	c.4251C>T	c.(4249-4251)AAC>AAT	p.N1417N	MED14_uc004dey.1_Silent_p.N319N	NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	1417					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						TCTTCAGAATGTTGCTGACCA	0.418													41	18					0	0	0	0	A	40513656	A	A	40513656	2	1	176	1	0	0	0	0	0	0	0	1	9485	1368	48	4		4	MED14	23	40513656	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	579699	40513656	114756904	419	33265											
KDM6A	7403	broad.mit.edu	37	chrX	44733171	44733172	+	Frame_Shift_Ins	INS	-	G	G																															ctgtgtctgtctccacagccINSgcctctttgggttcgtgaga																										TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:44733171_44733172insG	uc004dge.3	+	2	538_539	c.163_164insG	c.(163-165)CGCfs	p.R55fs	KDM6A_uc010nhk.2_Frame_Shift_Ins_p.R55fs|KDM6A_uc011mkz.1_Frame_Shift_Ins_p.R55fs|KDM6A_uc011mla.1_Frame_Shift_Ins_p.R55fs|KDM6A_uc011mlb.1_Frame_Shift_Ins_p.R55fs|KDM6A_uc011mlc.1_5'UTR	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	55					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(8)|p.0?(6)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TCTCCACAGCCGCCTCTTTGGG	0.649			D|N|F|S		renal|oesophageal SCC|MM								---	---	---								G	44733172	G	G	44733171	7	5	176	1	0	1	1	0	0	0	0	0	8176	666	23	0	169	0	KDM6A	23	44733171	Frame_Shift_Ins	INS	-	TCGA-CV-5441-01A-01D-1512-08	4219515	44733171	110537389	420	33266											
SPIN4	139886	broad.mit.edu	37	chrX	62570269	62570269	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatccatcacaggagctcGcgccaggaccatacccttcc	10	7	8	16	2	1	0	1	0	0	0	4	2	3	2	5	2	2	2	5	2	2	3			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:62570269G>C	uc004dvf.2	-	1	950	c.430C>G	c.(430-432)CGA>GGA	p.R144G		NM_001012968	NP_001012986	Q56A73	SPIN4_HUMAN	spindlin family, member 4	144					gamete generation					ovary(1)|lung(1)	2						ACAGGAGCTCGCGCCAGGACC	0.478													54	36					0	0	0	0	C	62570269	C	C	62570269	3	2	176	1	0	0	0	0	1	0	0	0	15122	1095	38	3	323	3	SPIN4	23	62570269	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	17837098	62570269	92700291	421	33267											
ZMYM3	9203	broad.mit.edu	37	chrX	70467681	70467681	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgactccgcgctggcaggtcTgggagcagtaagtacaagtg	9	8	15	9	2	1	1	0	1	1	0	2	2	2	2	1	3	2	5	1	3	3	2			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:70467681T>G	uc004dzh.1	-	12	2138	c.2051A>C	c.(2050-2052)CAG>CCG	p.Q684P	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.Q684P|ZMYM3_uc004dzj.1_Missense_Mutation_p.Q684P	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	684	MYM-type 8.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CTGGCAGGTCTGGGAGCAGTA	0.532													19	5					0	0	0	0	G	70467681	G	G	70467681	3	3	176	1	0	0	0	0	1	0	0	0	17768	1580	55	5	2117	5	ZMYM3	23	70467681	Missense_Mutation	SNP	T	TCGA-CV-5441-01A-01D-1512-08	7897412	70467681	84802879	422	33268											
CXCR3	2833	broad.mit.edu	37	chrX	70836725	70836725	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtattggcagtgggtggcGttgaggcgctcgtcgtggtg	3	13	19	6	4	0	1	0	1	0	0	2	1	0	1	0	5	0	4	0	5	1	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:70836725G>A	uc004eaf.2	-	2	665	c.597C>T	c.(595-597)AAC>AAT	p.N199N	BCYRN1_uc011mpt.1_Intron|CXCR3_uc011mpx.1_Silent_p.N246N	NM_001504	NP_001495	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3 isoform A	199	Extracellular (Potential).				cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			ovary(2)|central_nervous_system(1)	3	Renal(35;0.156)					AGTGGGTGGCGTTGAGGCGCT	0.632													7	3					0	0	0	0	A	70836725	A	A	70836725	2	1	176	1	0	0	0	0	0	0	0	1	4109	1136	40	1		1	CXCR3	23	70836725	Silent	SNP	G	TCGA-CV-5441-01A-01D-1512-08	369044	70836725	84433835	423	33269											
RLIM	51132	broad.mit.edu	37	chrX	73811532	73811532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctaggttggtcatcatcatCctcatttaagaggaaaaact	13	13	7	8	0	5	1	4	0	1	1	6	2	6	2	1	3	1	1	1	3	4	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:73811532C>T	uc004ebu.2	-	5	1908	c.1618G>A	c.(1618-1620)GAT>AAT	p.D540N	RLIM_uc004ebw.2_Missense_Mutation_p.D540N	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	540					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TCATCATCATCCTCATTTAAG	0.453													16	11					0	0	0	0	T	73811532	T	T	73811532	3	4	176	1	0	0	0	0	1	0	0	0	13455	855	30	2	260	2	RLIM	23	73811532	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	2974807	73811532	81459028	424	33270											
SH2D1A	4068	broad.mit.edu	37	chrX	123504071	123504071	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttccggaaaataaaaaatCtcatttcagcatttcagaag	17	12	5	7	1	3	1	3	0	1	1	5	2	4	2	1	1	1	1	1	1	6	4			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:123504071C>A	uc004euf.3	+	3	592	c.247C>A	c.(247-249)CTC>ATC	p.L83I	SH2D1A_uc004euh.3_Missense_Mutation_p.L83I|SH2D1A_uc004eug.3_Intron|SH2D1A_uc010nqw.2_Intron|SH2D1A_uc004eui.3_RNA|SH2D1A_uc010nqx.2_Intron	NM_002351	NP_002342	O60880	SH21A_HUMAN	SH2 domain protein 1A isoform 1	83	SH2.				cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity				0						AATAAAAAATCTCATTTCAGC	0.373									X-linked_Lymphoproliferative_syndrome				66	34					2.17656e-39	3.34557e-39	1	0	A	123504071	A	A	123504071	3	1	176	1	0	0	0	0	1	0	0	0	14295	913	32	2	257	2	SH2D1A	23	123504071	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	49692539	123504071	31766489	425	33271											
MAGEC1	9947	broad.mit.edu	37	chrX	140995750	140995750	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgagagtcctctccagagtCctgtgatctccttctcctcc	5	13	7	16	0	3	3	0	2	3	2	9	4	6	3	6	0	0	0	6	0	0	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:140995750C>T	uc004fbt.2	+	4	2846	c.2560C>T	c.(2560-2562)CCT>TCT	p.P854S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	854							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCAGAGTCCTGTGATCTC	0.507										HNSCC(15;0.026)			99	74					0	0	0	0	T	140995750	T	T	140995750	3	4	176	1	0	0	0	0	1	0	0	0	9233	855	30	2	2566	2	MAGEC1	23	140995750	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	17491679	140995750	14274810	426	33272											
AFF2	2334	broad.mit.edu	37	chrX	148037568	148037568	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaaagtgtggagcttcatGacccaccaagaggccgcaac	14	5	11	11	1	1	3	1	1	0	2	1	4	1	4	3	2	2	2	3	2	4	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:148037568G>C	uc004fcp.2	+	11	2472	c.1993G>C	c.(1993-1995)GAC>CAC	p.D665H	AFF2_uc004fcq.2_Missense_Mutation_p.D655H|AFF2_uc004fcr.2_Missense_Mutation_p.D626H|AFF2_uc011mxb.1_Missense_Mutation_p.D630H|AFF2_uc004fcs.2_Missense_Mutation_p.D632H|AFF2_uc011mxc.1_Missense_Mutation_p.D306H	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	665					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GGAGCTTCATGACCCACCAAG	0.488													56	45					0	0	0	0	C	148037568	C	C	148037568	3	2	176	1	0	0	0	0	1	0	0	0	357	1290	45	2	2090	2	AFF2	23	148037568	Missense_Mutation	SNP	G	TCGA-CV-5441-01A-01D-1512-08	7041818	148037568	7232992	427	33273											
ABCD1	215	broad.mit.edu	37	chrX	153009062	153009062	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggctggagcagcagctggCgggcattcccaagatgcagc	8	5	16	12	2	0	1	0	0	0	1	1	2	1	2	1	4	5	6	1	4	1	1			TCGA-CV-5441-01A-01D-1512-08	TCGA-CV-5441-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57f2873-a4ae-4fc0-9d4c-e1f4ef47482e	79ffab90-e307-45fb-a6ce-0d9aea0b7552	g.chrX:153009062C>A	uc004fif.2	+	10	2510	c.2111C>A	c.(2110-2112)GCG>GAG	p.A704E	ABCD1_uc004fig.2_Missense_Mutation_p.A204E|ABCD1_uc004fih.2_RNA	NM_000033	NP_000024	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member	704					fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGCAGCTGGCGGGCATTCCC	0.682													4	2					2.0095e-06	2.24821e-06	1	0	A	153009062	A	A	153009062	3	1	176	1	0	0	0	0	1	0	0	0	60	768	27	3	2149	3	ABCD1	23	153009062	Missense_Mutation	SNP	C	TCGA-CV-5441-01A-01D-1512-08	4971494	153009062	2261498	428	33274											
ZBTB48	3104	broad.mit.edu	37	chr1	6648997	6648997	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cccacctgcggaggcacatgGagatccacgaccgggtagag	10	4	14	13	3	0	2	0	0	0	2	1	5	1	3	4	4	1	2	4	4	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:6648997G>C	uc009vmc.1	+	11	1915	c.1792G>C	c.(1792-1794)GAG>CAG	p.E598Q	ZBTB48_uc001anx.2_Missense_Mutation_p.E598Q|ZBTB48_uc009vmd.1_Missense_Mutation_p.E598Q|ZBTB48_uc001any.1_Missense_Mutation_p.E236Q	NM_005341	NP_005332	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	598	C2H2-type 11.					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		GAGGCACATGGAGATCCACGA	0.662													37	112					0	0	0	0	C	6648997	C	C	6648997	3	2	177	1	0	0	0	0	1	0	0	0	17616	1175	41	2	1830	2	ZBTB48	1	6648997	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08		6648997	242601624	1	33275											
NPPA	4878	broad.mit.edu	37	chr1	11907385	11907385	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccggtccagggaggcacctCagggagggggctgagagcag	8	3	19	11	1	1	1	1	1	0	1	2	4	2	3	3	6	1	3	3	6	0	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:11907385C>T	uc001ati.2	-	2	334	c.235G>A	c.(235-237)GAG>AAG	p.E79K	CLCN6_uc010oav.1_Intron|CLCN6_uc010oaw.1_Intron|CLCN6_uc010oax.1_Intron|CLCN6_uc010oay.1_Intron|CLCN6_uc010oaz.1_Intron|CLCN6_uc010oba.1_Intron	NM_006172	NP_006163	P01160	ANF_HUMAN	natriuretic peptide precursor A preproprotein	79					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGGCACCTCAGGGAGGGGG	0.617													34	101					0	0	0	0	T	11907385	T	T	11907385	3	4	177	1	0	0	0	0	1	0	0	0	10645	835	29	2	228	2	NPPA	1	11907385	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	5258388	11907385	237343236	2	33276											
VPS13D	55187	broad.mit.edu	37	chr1	12328789	12328789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccagatggccccgtttttGagatgctgtatgagagaaat	11	12	11	7	1	0	4	0	2	0	3	1	6	1	4	3	1	1	3	3	1	2	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:12328789G>A	uc001atv.2	+	16	1969	c.1828G>A	c.(1828-1830)GAG>AAG	p.E610K	VPS13D_uc001atw.2_Missense_Mutation_p.E610K	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	610					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCCCGTTTTTGAGATGCTGTA	0.468													133	286					0	0	0	0	A	12328789	A	A	12328789	3	1	177	1	0	0	0	0	1	0	0	0	17260	1291	45	2	1886	2	VPS13D	1	12328789	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	421404	12328789	236921832	3	33277											
PRAMEF18	391003	broad.mit.edu	37	chr1	13474787	13474788	+	Frame_Shift_Ins	INS	-	G	G																															ggaccaaagaagatcctgttINSgggctcccttacttccctca																										TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:13474787_13474788insG	uc009vnu.1	-	3	1388_1389	c.1341_1342insC	c.(1339-1344)CCCAACfs	p.P447fs		NM_001099850	NP_001093320	Q5VWM3	PRA18_HUMAN	PRAME family member 18	447_448											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAGATCCTGTTGGGCTCCCTTA	0.564													---	---	---								G	13474788	G	G	13474787	7	5	177	1	0	1	1	0	0	0	0	0	12493	1812	63	0	101	0	PRAMEF18	1	13474787	Frame_Shift_Ins	INS	-	TCGA-CV-5442-01A-01D-1512-08	1145998	13474787	235775834	4	33278											
C1orf172	126695	broad.mit.edu	37	chr1	27277965	27277965	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctctttcgggtactaatgcGaatgatgccgcgtaccaggc	8	10	12	11	4	1	1	0	1	1	0	2	2	1	1	2	2	4	3	2	2	4	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:27277965G>A	uc001bni.1	-	2	996	c.907C>T	c.(907-909)CGC>TGC	p.R303C		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	303										large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GTACTAATGCGAATGATGCCG	0.607													25	48					0	0	0	0	A	27277965	A	A	27277965	3	1	177	1	0	0	0	0	1	0	0	0	2022	1058	37	1	301	1	C1orf172	1	27277965	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	13803178	27277965	221972656	5	33279											
DNAJC8	22826	broad.mit.edu	37	chr1	28555483	28555483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaggacgggtcagtctttCaatctgatttttcgaagtta	10	14	9	8	2	4	1	2	1	2	0	5	3	4	2	1	2	0	1	1	2	3	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:28555483C>T	uc001bpn.2	-	2	163	c.130G>A	c.(130-132)GAA>AAA	p.E44K	DNAJC8_uc001bpo.2_RNA	NM_014280	NP_055095	O75937	DNJC8_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 8	44					nuclear mRNA splicing, via spliceosome|protein folding	nucleoplasm	heat shock protein binding|unfolded protein binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.08e-05)|all_lung(284;4.29e-05)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.0105)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		OV - Ovarian serous cystadenocarcinoma(117;2.81e-22)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00275)|BRCA - Breast invasive adenocarcinoma(304;0.0059)|STAD - Stomach adenocarcinoma(196;0.00671)|READ - Rectum adenocarcinoma(331;0.0649)		GTCAGTCTTTCAATCTGATTT	0.378													43	111					0	0	0	0	T	28555483	T	T	28555483	3	4	177	1	0	0	0	0	1	0	0	0	4677	835	29	2	663	2	DNAJC8	1	28555483	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	1277518	28555483	220695138	6	33280											
KIF2C	11004	broad.mit.edu	37	chr1	45218850	45218850	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagtggctgaaataccattGaggatggtcagcgaggagat	12	8	15	6	1	1	3	1	2	0	1	1	6	1	4	1	4	2	2	1	4	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:45218850G>A	uc001cmg.3	+	6	601	c.486G>A	c.(484-486)TTG>TTA	p.L162L	KIF2C_uc010olb.1_Intron|KIF2C_uc010olc.1_Silent_p.L49L|KIF2C_uc001cmh.3_Silent_p.L108L	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	162	Globular (Potential).				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AAATACCATTGAGGATGGTCA	0.547													51	98					0	0	0	0	A	45218850	A	A	45218850	2	1	177	1	0	0	0	0	0	0	0	1	8338	1281	45	2		2	KIF2C	1	45218850	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	16663367	45218850	204031771	7	33281											
HS2ST1	9653	broad.mit.edu	37	chr1	87538628	87538628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctttccagaaagggctattGcaagacacgaagtccgagaa	14	8	10	9	2	1	3	0	0	1	3	3	5	3	3	2	1	1	2	2	1	5	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:87538628G>A	uc010osk.1	+	2	521	c.136G>A	c.(136-138)GCA>ACA	p.A46T	HS2ST1_uc001dmc.3_Missense_Mutation_p.A46T|LOC339524_uc001dme.1_Missense_Mutation_p.A7T	NM_012262	NP_036394	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1 isoform	46	Lumenal (Potential).					Golgi membrane|integral to membrane				central_nervous_system(1)	1		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		AAGGGCTATTGCAAGACACGA	0.398													14	42					0	0	0	0	A	87538628	A	A	87538628	3	1	177	1	0	0	0	0	1	0	0	0	7401	1319	46	4	142	4	HS2ST1	1	87538628	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	42319778	87538628	161711993	8	33282											
GBP2	2634	broad.mit.edu	37	chr1	89582907	89582907	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcattaaagcttttacttttCttatcagtacctacaggaat	12	17	4	8	0	3	0	2	0	1	0	3	1	3	1	1	1	4	2	1	1	7	8			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:89582907C>T	uc001dmz.1	-	6	907	c.636G>A	c.(634-636)AAG>AAA	p.K212K	GBP2_uc001dmy.1_RNA	NM_004120	NP_004111	P32456	GBP2_HUMAN	guanylate binding protein 2,	212					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)	1		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		TTTTACTTTTCTTATCAGTAC	0.358													32	32					0	0	0	0	T	89582907	T	T	89582907	2	4	177	1	0	0	0	0	0	0	0	1	6309	912	32	2		2	GBP2	1	89582907	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2044279	89582907	159667714	9	33283											
GBP5	115362	broad.mit.edu	37	chr1	89730647	89730647	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtcagcaccaggttctttaGaccttcatggaagaaagaaa	14	9	10	8	0	3	3	2	0	1	3	3	4	3	4	2	3	1	2	2	3	4	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:89730647G>C	uc001dnc.2	-	8	1408	c.871C>G	c.(871-873)CTA>GTA	p.L291V	GBP5_uc001dnd.2_Missense_Mutation_p.L291V|GBP5_uc001dne.1_Missense_Mutation_p.L291V	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	291						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		AGGTTCTTTAGACCTTCATGG	0.418													35	72					0	0	0	0	C	89730647	C	C	89730647	3	2	177	1	0	0	0	0	1	0	0	0	6312	933	33	2	909	2	GBP5	1	89730647	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	147740	89730647	159519974	10	33284											
C1orf59	113802	broad.mit.edu	37	chr1	109197402	109197402	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctccacaacggagccatGatacaatgtgatggtcaaat	13	10	8	10	1	2	2	1	2	1	0	4	3	3	3	2	2	3	0	2	2	4	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:109197402G>T	uc001dvt.3	-	5	572	c.334C>A	c.(334-336)CAT>AAT	p.H112N	C1orf59_uc001dvu.3_Missense_Mutation_p.H112N|C1orf59_uc009wer.2_Missense_Mutation_p.H112N	NM_001102592	NP_001096062	Q5T8I9	HENMT_HUMAN	hypothetical protein LOC113802	112					gene silencing by RNA|piRNA metabolic process	P granule	metal ion binding|O-methyltransferase activity|RNA binding|RNA methyltransferase activity				0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0152)|Lung(183;0.0895)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.163)		ACGGAGCCATGATACAATGTG	0.383													10	62					0.00010058	0.000102252	1	0	T	109197402	T	T	109197402	3	4	177	1	0	0	0	0	1	0	0	0	2061	1290	45	2	863	2	C1orf59	1	109197402	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	19466755	109197402	140053219	11	33285											
MAGI3	260425	broad.mit.edu	37	chr1	114133210	114133210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaattatatgatgagagatGagactctggaaccactgccc	14	9	10	8	0	1	4	0	3	1	2	1	8	1	5	2	1	2	0	2	1	4	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:114133210G>A	uc001edk.2	+	5	1049	c.868G>A	c.(868-870)GAG>AAG	p.E290K	MAGI3_uc001edh.3_Missense_Mutation_p.E290K|MAGI3_uc001edi.3_Missense_Mutation_p.E290K|MAGI3_uc010owm.1_Missense_Mutation_p.E290K|MAGI3_uc001edj.2_Missense_Mutation_p.E11K	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	290					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATGAGAGATGAGACTCTGGA	0.413													23	112					0	0	0	0	A	114133210	A	A	114133210	3	1	177	1	0	0	0	0	1	0	0	0	9245	1291	45	2	886	2	MAGI3	1	114133210	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	4935808	114133210	135117411	12	33286											
MAGI3	260425	broad.mit.edu	37	chr1	114193781	114193781	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcatgacaactgctgctcGaaatggccatgtgttactaa	11	11	8	11	1	1	1	1	1	0	0	2	2	1	1	2	1	4	3	2	1	4	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:114193781G>A	uc001edk.2	+	14	2574	c.2393G>A	c.(2392-2394)CGA>CAA	p.R798Q	MAGI3_uc001edh.3_Missense_Mutation_p.R823Q|MAGI3_uc001edi.3_Missense_Mutation_p.R798Q|MAGI3_uc010owm.1_Missense_Mutation_p.R823Q|MAGI3_uc001edj.2_Missense_Mutation_p.R519Q	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	823	Interaction with BAI1.|PDZ 4.			R -> P (in Ref. 2; AAG43837).	apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTGCTGCTCGAAATGGCCAT	0.433													24	83					0	0	0	0	A	114193781	A	A	114193781	3	1	177	1	0	0	0	0	1	0	0	0	9245	1058	37	1	2447	1	MAGI3	1	114193781	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	60571	114193781	135056840	13	33287											
GATAD2B	57459	broad.mit.edu	37	chr1	153785835	153785835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	actgctcacatagaatcttaCcattcttttcttgcttccag	9	16	4	12	0	4	1	1	0	3	1	5	1	5	1	2	0	3	2	2	0	3	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:153785835C>T	uc001fdb.3	-	8	1554	c.1310G>A	c.(1309-1311)GGT>GAT	p.G437D		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	437	GATA-type.|CR2.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TAGAATCTTACCATTCTTTTC	0.468													41	103					0	0	0	0	T	153785835	T	T	153785835	3	4	177	1	0	0	0	0	1	0	0	0	6296	507	18	4	487	4	GATAD2B	1	153785835	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	39592054	153785835	95464786	14	33288											
C1orf104	284618	broad.mit.edu	37	chr1	155291198	155291198	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggacctggaggtccattCtgggcccggacctcttccag	6	8	13	14	1	2	0	0	0	2	0	4	3	4	3	5	5	0	0	5	5	0	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:155291198C>T	uc001fki.2	-	2	359	c.82G>A	c.(82-84)GAA>AAA	p.E28K	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_RNA|RUSC1_uc001fkj.2_Intron|RUSC1_uc001fkk.2_Intron|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank	NM_001039517	NP_001034606	Q66K80	RUAS1_HUMAN	hypothetical protein LOC284618	28											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.32e-10)|all cancers(21;3.51e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			GAGGTCCATTCTGGGCCCGGA	0.677													6	24					0	0	0	0	T	155291198	T	T	155291198	3	4	177	1	0	0	0	0	1	0	0	0	1987	922	32	2	632	2	C1orf104	1	155291198	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	1505363	155291198	93959423	15	33289											
DAP3	7818	broad.mit.edu	37	chr1	155686886	155686886	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggttccagttgagagtccGagagctatttcccgcaccaa	10	9	10	12	2	0	2	0	1	0	2	3	4	3	2	4	1	1	4	4	1	2	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:155686886G>A	uc001flq.2	+	3	304	c.135G>A	c.(133-135)CCG>CCA	p.P45P	DAP3_uc001flr.2_Silent_p.P45P|DAP3_uc001fls.2_Silent_p.P45P|DAP3_uc010pgl.1_Intron|DAP3_uc001flt.2_Silent_p.P45P|DAP3_uc001flu.2_Silent_p.P45P|DAP3_uc010pgm.1_Silent_p.P45P	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	45					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TTGAGAGTCCGAGAGCTATTT	0.423													17	133					0	0	0	0	A	155686886	A	A	155686886	2	1	177	1	0	0	0	0	0	0	0	1	4251	1045	37	1		1	DAP3	1	155686886	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	395688	155686886	93563735	16	33290											
C1orf92	149499	broad.mit.edu	37	chr1	156897321	156897321	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctctgcggaacaataacatCgacgaccgcggggcgcaact	11	6	11	13	6	1	0	0	0	1	0	3	3	1	1	1	3	4	1	1	3	4	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:156897321C>T	uc001fqm.2	+	7	868	c.696C>T	c.(694-696)ATC>ATT	p.I232I	C1orf92_uc001fql.2_Silent_p.I17I	NM_144702	NP_653303	Q8N4P6	LRC71_HUMAN	hypothetical protein LOC149499	232	LRR 3.										0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ACAATAACATCGACGACCGCG	0.627													6	24					0	0	0	0	T	156897321	T	T	156897321	2	4	177	1	0	0	0	0	0	0	0	1	2079	874	31	1		1	C1orf92	1	156897321	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	1210435	156897321	92353300	17	33291											
PEA15	8682	broad.mit.edu	37	chr1	160183267	160183267	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaattggctcccccaccgaaGaaggcctgagcaagggggag	12	4	14	11	1	0	2	0	1	0	1	1	4	1	3	4	4	1	2	4	4	4	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:160183267G>A	uc001fvk.2	+	4	574	c.384G>A	c.(382-384)AAG>AAA	p.K128K	PEA15_uc001fvl.2_Silent_p.K149K|PEA15_uc001fvm.2_Silent_p.K106K	NM_003768	NP_003759	Q15121	PEA15_HUMAN	phosphoprotein enriched in astrocytes 15	128	Microtubule-binding (Potential).				anti-apoptosis|apoptosis|carbohydrate transport|negative regulation of glucose import	cytoplasm|microtubule associated complex	protein binding				0	all_cancers(52;3.11e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCCCACCGAAGAAGGCCTGAG	0.577													14	91					0	0	0	0	A	160183267	A	A	160183267	2	1	177	1	0	0	0	0	0	0	0	1	11765	933	33	2		2	PEA15	1	160183267	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3285946	160183267	89067354	18	33292											
NCSTN	23385	broad.mit.edu	37	chr1	160327005	160327005	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagccgctggaaagatatcCgtgcccggatatttctcatc	10	10	10	11	3	1	2	1	0	1	2	4	4	2	4	3	2	2	1	3	2	3	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:160327005C>T	uc001fvx.2	+	16	2093	c.1969C>T	c.(1969-1971)CGT>TGT	p.R657C	NCSTN_uc001fvy.2_Missense_Mutation_p.R637C|NCSTN_uc010pjf.1_Missense_Mutation_p.R519C|NCSTN_uc001fvz.2_Missense_Mutation_p.R437C|NCSTN_uc010pjg.1_Missense_Mutation_p.R399C	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	657	Extracellular (Potential).			R -> H (in Ref. 5; AAH47621).	amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GAAAGATATCCGTGCCCGGAT	0.512													19	43					0	0	0	0	T	160327005	T	T	160327005	3	4	177	1	0	0	0	0	1	0	0	0	10295	652	23	1	2031	1	NCSTN	1	160327005	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	143738	160327005	88923616	19	33293											
CFHR4	10877	broad.mit.edu	37	chr1	196871632	196871632	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actatactttccagcagctgCaggacaatcttattcctatt	11	14	5	11	0	1	0	0	0	1	0	3	1	3	1	2	1	4	3	2	1	5	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:196871632C>A	uc001gto.2	+	2	212	c.143C>A	c.(142-144)GCA>GAA	p.A48E	CFHR4_uc009wyy.2_Missense_Mutation_p.A47E|CFHR4_uc001gtp.2_Missense_Mutation_p.A48E	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	48	Sushi 1.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						CCAGCAGCTGCAGGACAATCT	0.368													148	91					5.38354e-89	5.81106e-89	1	0	A	196871632	A	A	196871632	3	1	177	1	0	0	0	0	1	0	0	0	3302	710	25	4	149	4	CFHR4	1	196871632	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	36544627	196871632	52378989	20	33294											
CRB1	23418	broad.mit.edu	37	chr1	197404461	197404461	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggaggaaactgtgaagaCatctatagctcttatcattg	13	12	9	7	0	3	2	1	1	2	1	3	4	3	4	0	2	2	1	0	2	5	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:197404461C>T	uc001gtz.2	+	9	3603	c.3468C>T	c.(3466-3468)GAC>GAT	p.D1156D	CRB1_uc010poz.1_Silent_p.D1132D|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.D1044D|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Silent_p.D637D|CRB1_uc001gub.1_Silent_p.D805D	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1156	Extracellular (Potential).|EGF-like 15.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ACTGTGAAGACATCTATAGCT	0.443													70	59					0	0	0	0	T	197404461	T	T	197404461	2	4	177	1	0	0	0	0	0	0	0	1	3863	477	17	4		4	CRB1	1	197404461	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	532829	197404461	51846160	21	33295											
DDX59	83479	broad.mit.edu	37	chr1	200619777	200619777	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgtcaagcacttgttgttGaaaacccatctttaacatgg	13	13	7	8	0	2	1	1	1	1	0	2	1	2	1	1	1	3	3	1	1	5	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:200619777G>C	uc009wzk.2	-	5	1333	c.1090C>G	c.(1090-1092)CAA>GAA	p.Q364E	DDX59_uc010ppl.1_Missense_Mutation_p.Q364E	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	364	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						ACTTGTTGTTGAAAACCCATC	0.358													16	77					0	0	0	0	C	200619777	C	C	200619777	3	2	177	1	0	0	0	0	1	0	0	0	4393	1299	45	2	785	2	DDX59	1	200619777	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3215316	200619777	48630844	22	33296											
IGFN1	91156	broad.mit.edu	37	chr1	201193890	201193890	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgtcactaaggatggcctCacccagcttctgatccctgt	8	11	8	14	0	3	1	2	1	1	0	4	2	4	2	3	2	1	1	3	2	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:201193890C>T	uc001gwc.2	+	10	2626	c.1854C>T	c.(1852-1854)CTC>CTT	p.L618L	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						AGGATGGCCTCACCCAGCTTC	0.572													18	62					0	0	0	0	T	201193890	T	T	201193890	2	4	177	1	0	0	0	0	0	0	0	1	7629	813	29	2		2	IGFN1	1	201193890	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	574113	201193890	48056731	23	33297											
GOLT1A	127845	broad.mit.edu	37	chr1	204170910	204170910	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtcttcctcaggccaatGatgagggacaggcccgtcag	10	7	13	11	1	3	2	2	2	1	0	4	3	4	3	3	4	0	0	3	4	2	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:204170910G>A	uc001has.1	-	3	333	c.147C>T	c.(145-147)ATC>ATT	p.I49I	GOLT1A_uc001hat.1_Silent_p.I49I	NM_198447	NP_940849	Q6ZVE7	GOT1A_HUMAN	golgi transport 1 homolog A	49	Helical; Name=2; (Potential).				protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane					0	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			TCAGGCCAATGATGAGGGACA	0.592													35	115					0	0	0	0	A	204170910	A	A	204170910	2	1	177	1	0	0	0	0	0	0	0	1	6607	1280	45	2		2	GOLT1A	1	204170910	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	2977020	204170910	45079711	24	33298											
NFASC	23114	broad.mit.edu	37	chr1	204951100	204951100	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaggctgaaaatgacttcGggaagggccctgagccagag	11	6	14	10	1	0	4	0	3	0	1	2	5	1	5	3	3	1	1	3	3	3	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:204951100G>A	uc001hbj.2	+	21	2750	c.2422G>A	c.(2422-2424)GGG>AGG	p.G808R	NFASC_uc010pra.1_Missense_Mutation_p.G804R|NFASC_uc001hbi.2_Missense_Mutation_p.G804R|NFASC_uc010prb.1_Missense_Mutation_p.G819R|NFASC_uc010prc.1_Missense_Mutation_p.G375R|NFASC_uc001hbk.1_Missense_Mutation_p.G614R|NFASC_uc001hbl.1_Missense_Mutation_p.G58R	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	808	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AAATGACTTCGGGAAGGGCCC	0.602													14	28					0	0	0	0	A	204951100	A	A	204951100	3	1	177	1	0	0	0	0	1	0	0	0	10413	1116	39	1	2580	1	NFASC	1	204951100	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	780190	204951100	44299521	25	33299											
IL19	29949	broad.mit.edu	37	chr1	207010082	207010082	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagtagacaaccacggtctCaggagatgtctgatttccac	11	10	9	11	1	3	3	2	1	2	2	5	4	4	3	2	2	1	1	2	2	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:207010082C>T	uc001hep.2	+	3	1014	c.75C>T	c.(73-75)CTC>CTT	p.L25L	IL19_uc001heo.2_Silent_p.L63L|IL19_uc010prx.1_Silent_p.L25L	NM_013371	NP_037503	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 2 precursor	25					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			ACCACGGTCTCAGGAGATGTC	0.458													43	218					0	0	0	0	T	207010082	T	T	207010082	2	4	177	1	0	0	0	0	0	0	0	1	7688	813	29	2		2	IL19	1	207010082	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2058982	207010082	42240539	26	33300											
INTS7	25896	broad.mit.edu	37	chr1	212180042	212180042	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caagtaatttcagatcttgaAtagcaagtctctttactgcc	12	14	6	9	0	3	2	1	1	2	1	4	2	3	2	1	0	3	2	1	0	6	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:212180042A>G	uc001hiw.1	-	7	923	c.818T>C	c.(817-819)ATT>ACT	p.I273T	INTS7_uc009xdb.1_Missense_Mutation_p.I273T|INTS7_uc001hix.1_Missense_Mutation_p.I149T|INTS7_uc001hiy.1_Missense_Mutation_p.I273T|INTS7_uc010pta.1_Missense_Mutation_p.I224T	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	273					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CAGATCTTGAATAGCAAGTCT	0.313													37	111					0	0	0	0	G	212180042	G	G	212180042	3	3	177	1	0	0	0	0	1	0	0	0	7822	101	4	5	2126	5	INTS7	1	212180042	Missense_Mutation	SNP	A	TCGA-CV-5442-01A-01D-1512-08	5169960	212180042	37070579	27	33301											
GALNT2	2590	broad.mit.edu	37	chr1	230386252	230386252	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatggataagttctattttGaagaactggggaagtacgac	13	12	12	4	1	1	3	0	2	1	1	1	6	1	5	0	3	2	2	0	3	6	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:230386252G>A	uc010pwa.1	+	10	1027	c.955G>A	c.(955-957)GAA>AAA	p.E319K	GALNT2_uc010pvy.1_Missense_Mutation_p.E281K|GALNT2_uc010pvz.1_Intron	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	319	Lumenal (Potential).|Catalytic subdomain B.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GTTCTATTTTGAAGAACTGGG	0.493													19	53					0	0	0	0	A	230386252	A	A	230386252	3	1	177	1	0	0	0	0	1	0	0	0	6248	1291	45	2	993	2	GALNT2	1	230386252	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	18206210	230386252	18864369	28	33302											
NID1	4811	broad.mit.edu	37	chr1	236180568	236180568	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggttgttctgaacattcatCaatatctgcagcaaaaattt	13	14	7	7	0	4	1	2	1	2	0	4	1	4	1	0	1	3	4	0	1	5	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:236180568C>G	uc001hxo.2	-	10	2236	c.2134G>C	c.(2134-2136)GAT>CAT	p.D712H	NID1_uc009xgd.2_Intron	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	712	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GAACATTCATCAATATCTGCA	0.393													47	103					0	0	0	0	G	236180568	G	G	236180568	3	3	177	1	0	0	0	0	1	0	0	0	10468	826	29	2	1653	2	NID1	1	236180568	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	5794316	236180568	13070053	29	33303											
OR11L1	391189	broad.mit.edu	37	chr1	248004499	248004499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtggaaaaggtctttctccGgccagaggtggaagggattc	9	10	15	7	1	2	1	0	0	2	1	4	4	2	4	2	6	0	0	2	6	3	2	rs147783465	byFrequency	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:248004499G>A	uc001idn.1	-	1	700	c.700C>T	c.(700-702)CGG>TGG	p.R234W		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GTCTTTCTCCGGCCAGAGGTG	0.502													37	115					0	0	0	0	A	248004499	A	A	248004499	3	1	177	1	0	0	0	0	1	0	0	0	10984	1115	39	1	272	1	OR11L1	1	248004499	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	11823931	248004499	1246122	30	33304											
OR2T2	401992	broad.mit.edu	37	chr1	248616452	248616452	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaattcttcctgctgggtctCatggcctatgaccgctatgt	6	14	10	11	1	2	1	1	1	2	0	4	2	3	1	3	2	1	2	3	2	3	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:248616452C>T	uc001iek.1	+	1	354	c.354C>T	c.(352-354)CTC>CTT	p.L118L		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGCTGGGTCTCATGGCCTATG	0.547													19	246					0	0	0	0	T	248616452	T	T	248616452	2	4	177	1	0	0	0	0	0	0	0	1	11074	813	29	2		2	OR2T2	1	248616452	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	611953	248616452	634169	31	33305											
MYT1L	23040	broad.mit.edu	37	chr2	1843083	1843083	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggggcacccggaggcgctgCgatgggacgcgtacttccca	7	5	16	13	5	0	0	0	0	0	0	1	3	1	2	2	5	2	3	2	5	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:1843083C>T	uc002qxe.2	-	21	3745	c.2918G>A	c.(2917-2919)CGC>CAC	p.R973H	MYT1L_uc002qxd.2_Missense_Mutation_p.R971H|MYT1L_uc010ewk.2_5'UTR	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	973	C2HC-type 5.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGAGGCGCTGCGATGGGACGC	0.632													53	52					0	0	0	0	T	1843083	T	T	1843083	3	4	177	1	0	0	0	0	1	0	0	0	10160	768	27	1	662	1	MYT1L	2	1843083	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08		1843083	241356290	32	33306											
MYT1L	23040	broad.mit.edu	37	chr2	1926709	1926709	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttctgtcattcatgttttCtgagagcacaacaccgtgtc	9	15	7	10	1	4	1	2	1	2	1	5	2	4	1	1	0	2	2	1	0	1	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:1926709C>A	uc002qxe.2	-	10	1659	c.832G>T	c.(832-834)GAA>TAA	p.E278*	MYT1L_uc002qxd.2_Nonsense_Mutation_p.E278*|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	278					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TTCATGTTTTCTGAGAGCACA	0.423													84	131					1.42748e-55	1.53632e-55	1	0	A	1926709	A	A	1926709	4	1	177	1	0	0	0	0	0	1	0	0	10160	922	32	2	2786	2	MYT1L	2	1926709	Nonsense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	83626	1926709	241272664	33	33307											
NBAS	51594	broad.mit.edu	37	chr2	15417101	15417101	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atactgcagcctttcgtgatCaaagccaccaatagtagggt	12	10	9	10	1	1	1	1	1	0	0	2	1	1	1	3	1	4	2	3	1	5	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:15417101C>G	uc002rcc.1	-	43	5289	c.5263G>C	c.(5263-5265)GAT>CAT	p.D1755H	NBAS_uc010exl.1_Missense_Mutation_p.D827H|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1755										ovary(2)|liver(1)|skin(1)	4						CTTTCGTGATCAAAGCCACCA	0.443													23	40					0	0	0	0	G	15417101	G	G	15417101	3	3	177	1	0	0	0	0	1	0	0	0	10239	826	29	2	1892	2	NBAS	2	15417101	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	13490392	15417101	227782272	34	33308											
CLIP4	79745	broad.mit.edu	37	chr2	29356671	29356671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagagtgattttgaaaacatCgaaaccaaaaggcaagtatt	19	9	8	5	1	0	3	0	2	0	1	1	4	0	3	1	1	2	2	1	1	8	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:29356671C>T	uc002rmv.2	+	5	757	c.518C>T	c.(517-519)TCG>TTG	p.S173L	CLIP4_uc002rmu.2_Missense_Mutation_p.S173L|CLIP4_uc010ezm.1_Missense_Mutation_p.S173L|CLIP4_uc002rmw.2_RNA|CLIP4_uc010ymn.1_Missense_Mutation_p.S155L	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	173	ANK 2.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					TTGAAAACATCGAAACCAAAA	0.333													27	54					0	0	0	0	T	29356671	T	T	29356671	3	4	177	1	0	0	0	0	1	0	0	0	3550	893	31	1	532	1	CLIP4	2	29356671	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	13939570	29356671	213842702	35	33309											
VIT	5212	broad.mit.edu	37	chr2	36956606	36956606	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtacattcaaacaaagaaacGgcaaagaagattaaaaggcc	21	5	8	7	1	1	3	1	0	0	3	1	3	1	3	1	2	3	2	1	2	8	3	rs147850488		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:36956606G>A	uc002rpl.2	+	3	311	c.90G>A	c.(88-90)ACG>ACA	p.T30T	VIT_uc002rpk.2_Silent_p.T23T|VIT_uc010ynf.1_Silent_p.T23T|VIT_uc002rpm.2_Silent_p.T23T|VIT_uc010ezv.2_Silent_p.T23T|VIT_uc010ezw.2_Silent_p.T23T	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	30						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				ACAAAGAAACGGCAAAGAAGA	0.299													32	57					0	0	0	0	A	36956606	A	A	36956606	2	1	177	1	0	0	0	0	0	0	0	1	17239	1103	39	1		1	VIT	2	36956606	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	7599935	36956606	206242767	36	33310											
KLRAQ1	129285	broad.mit.edu	37	chr2	48681851	48681851	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacttcaagatgaactagctCtaagtgaaccacgaggcaag	15	8	9	9	1	2	3	1	2	1	1	2	4	2	3	1	1	4	2	1	1	7	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:48681851C>T	uc002rwm.2	+	3	429	c.244C>T	c.(244-246)CTA>TTA	p.L82L	KLRAQ1_uc002rwi.1_Silent_p.L82L|KLRAQ1_uc002rwj.2_Silent_p.L82L|KLRAQ1_uc002rwl.2_Silent_p.L36L|KLRAQ1_uc002rwk.2_Silent_p.L82L|KLRAQ1_uc010yok.1_Silent_p.L82L	NM_001135629	NP_001129101	Q6ZMI0	KLRAQ_HUMAN	KLRAQ motif containing 1 isoform 1	82	Potential.									ovary(1)	1						TGAACTAGCTCTAAGTGAACC	0.428													33	43					0	0	0	0	T	48681851	T	T	48681851	2	4	177	1	0	0	0	0	0	0	0	1	8452	912	32	2		2	KLRAQ1	2	48681851	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	11725245	48681851	194517522	37	33311											
MEIS1	4211	broad.mit.edu	37	chr2	66691284	66691284	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacacggcatctactcgttCaggaggaaccccaggccctt	9	8	10	14	2	2	1	1	1	1	0	3	3	2	3	3	4	2	2	3	4	2	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:66691284C>T	uc002sdu.2	+	7	1131	c.674C>T	c.(673-675)TCA>TTA	p.S225L	MEIS1_uc002sdt.2_Missense_Mutation_p.S225L|MEIS1_uc002sdv.2_Missense_Mutation_p.S223L|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_Missense_Mutation_p.S160L|MEIS1_uc002sdw.1_Missense_Mutation_p.S81L	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	225	Ser/Thr-rich.						sequence-specific DNA binding transcription factor activity				0						TCTACTCGTTCAGGAGGAACC	0.512													3	10					0	0	0	0	T	66691284	T	T	66691284	3	4	177	1	0	0	0	0	1	0	0	0	9520	838	29	2	700	2	MEIS1	2	66691284	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	18009433	66691284	176508089	38	33312											
ST6GAL2	84620	broad.mit.edu	37	chr2	107459920	107459920	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggtgcctcttcttcacccGcctcctctggacctgtgcag	3	11	9	18	2	4	0	1	0	3	0	5	1	5	1	6	2	2	1	6	2	0	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:107459920G>A	uc002tdq.2	-	2	633	c.514C>T	c.(514-516)CGG>TGG	p.R172W	ST6GAL2_uc002tdr.2_Missense_Mutation_p.R172W|ST6GAL2_uc002tds.3_Missense_Mutation_p.R172W	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	172	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						TTCTTCACCCGCCTCCTCTGG	0.657													53	81					0	0	0	0	A	107459920	A	A	107459920	3	1	177	1	0	0	0	0	1	0	0	0	15288	1086	38	1	1182	1	ST6GAL2	2	107459920	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	40768636	107459920	135739453	39	33313											
SCN3A	6328	broad.mit.edu	37	chr2	165995989	165995989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catgacctgcttcttaccttCcattgtgttggtcagaatgc	7	15	8	11	0	2	2	1	1	1	1	3	2	3	2	3	1	3	2	3	1	2	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:165995989C>T	uc002ucx.2	-	14	2641	c.2149G>A	c.(2149-2151)GAA>AAA	p.E717K	SCN3A_uc002ucy.2_Missense_Mutation_p.E668K|SCN3A_uc002ucz.2_Missense_Mutation_p.E668K|SCN3A_uc002uda.1_Missense_Mutation_p.E537K|SCN3A_uc002udb.1_Missense_Mutation_p.E537K	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	717						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTCTTACCTTCCATTGTGTTG	0.433													41	38					0	0	0	0	T	165995989	T	T	165995989	3	4	177	1	0	0	0	0	1	0	0	0	13983	864	30	2	3913	2	SCN3A	2	165995989	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	58536069	165995989	77203384	40	33314											
TTC21B	79809	broad.mit.edu	37	chr2	166758288	166758288	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataaaacttaattgctttttCatagtctcgctgagcaacag	13	14	6	8	1	2	1	1	1	1	0	3	1	2	1	0	0	4	3	0	0	5	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:166758288C>T	uc002udk.2	-	20	2834	c.2701G>A	c.(2701-2703)GAA>AAA	p.E901K		NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	901	TPR 13.					cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						ATTGCTTTTTCATAGTCTCGC	0.368													23	37					0	0	0	0	T	166758288	T	T	166758288	3	4	177	1	0	0	0	0	1	0	0	0	16756	835	29	2	1289	2	TTC21B	2	166758288	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	762299	166758288	76441085	41	33315											
SCN7A	6332	broad.mit.edu	37	chr2	167334107	167334107	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggctttaagtcttcttcttCatggtcttcattatgtgttt	5	22	7	7	0	6	0	2	0	4	0	6	0	6	0	0	2	0	2	0	2	2	8			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:167334107C>T	uc002udu.1	-	2	227	c.100G>A	c.(100-102)GAA>AAA	p.E34K	SCN7A_uc002udv.1_Missense_Mutation_p.E34K	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	34					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TCTTCTTCTTCATGGTCTTCA	0.388													10	10					0	0	0	0	T	167334107	T	T	167334107	3	4	177	1	0	0	0	0	1	0	0	0	13988	835	29	2	5044	2	SCN7A	2	167334107	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	575819	167334107	75865266	42	33316											
STAT1	6772	broad.mit.edu	37	chr2	191873691	191873691	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaaaaccaggtcatacctGaagattacgcttgcttttcc	13	11	6	11	1	1	2	1	1	0	1	2	2	2	2	3	1	4	2	3	1	5	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:191873691G>A	uc002usj.2	-	4	659	c.271C>T	c.(271-273)CAG>TAG	p.Q91*	STAT1_uc010fse.1_Nonsense_Mutation_p.Q91*|STAT1_uc002usk.2_Nonsense_Mutation_p.Q91*|STAT1_uc002usl.2_Nonsense_Mutation_p.Q93*|STAT1_uc010fsf.1_5'UTR	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	91					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GGTCATACCTGAAGATTACGC	0.368													26	3					0	0	0	0	A	191873691	A	A	191873691	4	1	177	1	0	0	0	0	0	1	0	0	15330	1299	45	2	2073	2	STAT1	2	191873691	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	24539584	191873691	51325682	43	33317											
ABCA12	26154	broad.mit.edu	37	chr2	215843708	215843708	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcttcggggagatgtgattgGatcattgctgtcacggccat	7	12	14	8	2	2	2	2	1	0	1	3	4	2	3	1	4	1	2	1	4	0	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:215843708G>A	uc002vew.2	-	32	5017	c.4797C>T	c.(4795-4797)ATC>ATT	p.I1599I	ABCA12_uc002vev.2_Silent_p.I1281I|ABCA12_uc010zjn.1_Silent_p.I526I	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1599					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GATGTGATTGGATCATTGCTG	0.448													44	48					0	0	0	0	A	215843708	A	A	215843708	2	1	177	1	0	0	0	0	0	0	0	1	30	1164	41	2		2	ABCA12	2	215843708	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	23970017	215843708	27355665	44	33318											
GIGYF2	26058	broad.mit.edu	37	chr2	233704679	233704679	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaacggcagcttcgagaaGaggtaaaattttaaagtaaa	18	8	11	4	2	0	3	0	0	0	3	1	5	0	3	0	2	2	4	0	2	8	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:233704679G>C	uc002vti.3	+	25	3224	c.2887G>C	c.(2887-2889)GAG>CAG	p.E963Q	GIGYF2_uc002vtj.3_Missense_Mutation_p.E984Q|GIGYF2_uc002vtk.3_Missense_Mutation_p.E963Q|GIGYF2_uc002vth.3_Missense_Mutation_p.E957Q|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.E794Q|GIGYF2_uc002vtq.3_Missense_Mutation_p.E296Q	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	963	Gln-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GCTTCGAGAAGAGGTAAAATT	0.448													9	23					0	0	0	0	C	233704679	C	C	233704679	3	2	177	1	0	0	0	0	1	0	0	0	6415	943	33	2	3039	2	GIGYF2	2	233704679	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	17860971	233704679	9494694	45	33319											
C2orf54	79919	broad.mit.edu	37	chr2	241834961	241834961	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctaccagcaggtccttgaGgacacacaggaccttgctgg	9	8	12	12	0	0	1	0	1	0	0	1	3	1	3	3	4	4	3	3	4	1	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:241834961G>A	uc002wae.3	-	1	613	c.454C>T	c.(454-456)CTC>TTC	p.L152F		NM_001085437	NP_001078906	Q08AI8	CB054_HUMAN	hypothetical protein LOC79919 isoform 1	152											0		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		AGGTCCTTGAGGACACACAGG	0.607													6	14					0	0	0	0	A	241834961	A	A	241834961	3	1	177	1	0	0	0	0	1	0	0	0	2185	1000	35	4	923	4	C2orf54	2	241834961	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	8130282	241834961	1364412	46	33320											
GRM7	2917	broad.mit.edu	37	chr3	7188201	7188201	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgaccggcgctatgacttCttctctcgcgtggtgccacc	5	11	11	14	4	2	2	0	2	2	0	4	3	2	2	3	2	1	1	3	2	1	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:7188201C>G	uc003bqm.2	+	2	856	c.582C>G	c.(580-582)TTC>TTG	p.F194L	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.F194L|GRM7_uc003bql.2_Missense_Mutation_p.F194L	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	194	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GCTATGACTTCTTCTCTCGCG	0.537													44	118					0	0	0	0	G	7188201	G	G	7188201	3	3	177	1	0	0	0	0	1	0	0	0	6841	912	32	2	588	2	GRM7	3	7188201	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08		7188201	190834229	47	33321											
BRPF1	7862	broad.mit.edu	37	chr3	9783100	9783100	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcgtggaattgatccgcaagCgggaaaaactcaaaagggag	15	6	13	7	3	1	1	1	1	0	0	3	4	2	4	1	3	2	1	1	3	6	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:9783100C>T	uc003bse.2	+	5	2230	c.1831C>T	c.(1831-1833)CGG>TGG	p.R611W	BRPF1_uc003bsf.2_Missense_Mutation_p.R611W|BRPF1_uc003bsg.2_Missense_Mutation_p.R611W|BRPF1_uc011ati.1_Missense_Mutation_p.R611W	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	611	Required for RUNX1 and RUNX2 transcriptional activation.|Interaction with MEAF6 and ING5.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					GATCCGCAAGCGGGAAAAACT	0.428													22	103					0	0	0	0	T	9783100	T	T	9783100	3	4	177	1	0	0	0	0	1	0	0	0	1525	759	27	1	1845	1	BRPF1	3	9783100	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2594899	9783100	188239330	48	33322											
DLEC1	9940	broad.mit.edu	37	chr3	38103718	38103718	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgagaagcgttccgtccaGaagaaagagctgaacaagaa	16	6	12	7	2	0	6	0	2	0	5	2	7	2	6	2	0	3	2	2	0	6	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:38103718G>C	uc003cho.1	+	4	753	c.732G>C	c.(730-732)CAG>CAC	p.Q244H	DLEC1_uc003chp.1_Missense_Mutation_p.Q244H|DLEC1_uc010hgv.1_Missense_Mutation_p.Q244H|DLEC1_uc010hgw.1_5'Flank|DLEC1_uc003chq.1_5'Flank	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	244					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GTTCCGTCCAGAAGAAAGAGC	0.453													29	73					0	0	0	0	C	38103718	C	C	38103718	3	2	177	1	0	0	0	0	1	0	0	0	4574	933	33	2	746	2	DLEC1	3	38103718	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	28320618	38103718	159918712	49	33323											
SCN10A	6336	broad.mit.edu	37	chr3	38755460	38755460	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagacttacccgcatgccttCaaatcgagaaagagcccgca	13	6	8	14	3	1	3	1	0	0	3	2	4	1	3	3	0	3	2	3	0	3	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:38755460C>G	uc003ciq.2	-	21	3793	c.3793G>C	c.(3793-3795)GAA>CAA	p.E1265Q		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1265	III.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CGCATGCCTTCAAATCGAGAA	0.358													32	89					0	0	0	0	G	38755460	G	G	38755460	3	3	177	1	0	0	0	0	1	0	0	0	13977	835	29	2	2105	2	SCN10A	3	38755460	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	651742	38755460	159266970	50	33324											
SNRK	54861	broad.mit.edu	37	chr3	43388882	43388882	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggaccttgaggatgacctCacggccactcctttgtccca	8	9	9	15	1	1	2	1	2	0	0	3	4	3	4	5	3	0	0	5	3	0	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:43388882C>G	uc003cms.3	+	7	1463	c.1131C>G	c.(1129-1131)CTC>CTG	p.L377L	SNRK_uc003cmt.3_Silent_p.L377L|SNRK_uc010hik.2_Silent_p.L377L|SNRK_uc011azr.1_Silent_p.L171L	NM_017719	NP_060189	Q9NRH2	SNRK_HUMAN	SNF related kinase	377					myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		AGGATGACCTCACGGCCACTC	0.522													26	110					0	0	0	0	G	43388882	G	G	43388882	2	3	177	1	0	0	0	0	0	0	0	1	14915	813	29	2		2	SNRK	3	43388882	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	4633422	43388882	154633548	51	33325											
TGM4	7047	broad.mit.edu	37	chr3	44951844	44951844	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtgacctcaataagacctcGcagatccaaggtcaaggtac	13	8	9	11	1	2	3	2	1	0	2	4	3	3	3	3	2	1	2	3	2	5	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:44951844G>A	uc003coc.3	+	11	1663	c.1590G>A	c.(1588-1590)TCG>TCA	p.S530S		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	530					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	ATAAGACCTCGCAGATCCAAG	0.507													27	63					0	0	0	0	A	44951844	A	A	44951844	2	1	177	1	0	0	0	0	0	0	0	1	15898	1074	38	1		1	TGM4	3	44951844	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	1562962	44951844	153070586	52	33326											
TEX264	51368	broad.mit.edu	37	chr3	51708495	51708495	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccacatggggctctatggtGagactgggcggcttttcact	6	12	13	10	1	2	1	1	1	1	1	3	2	3	1	1	5	0	2	1	5	1	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:51708495G>A	uc010hls.2	+	3	344	c.175G>A	c.(175-177)GAG>AAG	p.E59K	TEX264_uc003dbk.3_Missense_Mutation_p.E59K|TEX264_uc010hlt.2_Intron|TEX264_uc003dbl.3_Missense_Mutation_p.E59K|TEX264_uc003dbm.3_Missense_Mutation_p.E98K	NM_001129884	NP_001123356	Q9Y6I9	TX264_HUMAN	testis expressed 264 precursor	59						extracellular region					0				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)		GCTCTATGGTGAGACTGGGCG	0.587													33	94					0	0	0	0	A	51708495	A	A	51708495	3	1	177	1	0	0	0	0	1	0	0	0	15849	1291	45	2	177	2	TEX264	3	51708495	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	6756651	51708495	146313935	53	33327											
GRM2	2912	broad.mit.edu	37	chr3	51752122	51752122	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggactcgacaacgtcatcGctttgaagaccccatactcc	10	9	8	14	3	1	2	1	1	0	1	4	4	2	3	3	1	2	1	3	1	3	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:51752122G>A	uc010hlv.2	+	6	2852	c.2613G>A	c.(2611-2613)TCG>TCA	p.S871S	GRM2_uc003dbo.3_Silent_p.S253S|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	871	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CAACGTCATCGCTTTGAAGAC	0.582													81	227					0	0	0	0	A	51752122	A	A	51752122	2	1	177	1	0	0	0	0	0	0	0	1	6836	1074	38	1		1	GRM2	3	51752122	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	43627	51752122	146270308	54	33328											
TLR9	54106	broad.mit.edu	37	chr3	52256442	52256442	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggacaagtccagccagatCaaaccgctcaggccttggaa	12	6	11	12	1	2	1	2	0	0	1	3	3	3	3	4	3	2	1	4	3	3	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:52256442C>G	uc003dda.1	-	2	2524	c.1890G>C	c.(1888-1890)TTG>TTC	p.L630F	TLR9_uc003ddb.2_Missense_Mutation_p.L727F	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	630	LRR 21.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CCAGCCAGATCAAACCGCTCA	0.612													17	73					0	0	0	0	G	52256442	G	G	52256442	3	3	177	1	0	0	0	0	1	0	0	0	16024	825	29	2	1212	2	TLR9	3	52256442	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	504320	52256442	145765988	55	33329											
TLR9	54106	broad.mit.edu	37	chr3	52257323	52257323	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaggacaggttaagcttgcGcagctgtgttaggccctgga	9	9	15	8	1	0	0	0	0	0	0	0	3	0	2	1	4	3	5	1	4	3	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:52257323G>A	uc003dda.1	-	2	1643	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C	TLR9_uc003ddb.2_Missense_Mutation_p.R434C	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	337	LRR 11.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	TTAAGCTTGCGCAGCTGTGTT	0.557													43	97					0	0	0	0	A	52257323	A	A	52257323	3	1	177	1	0	0	0	0	1	0	0	0	16024	1087	38	1	2093	1	TLR9	3	52257323	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	881	52257323	145765107	56	33330											
DNAH1	25981	broad.mit.edu	37	chr3	52425293	52425293	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcaagccatgtctcctggaGaacgtgggcgaggagctaga	10	6	16	9	2	1	2	0	0	1	2	2	5	1	3	2	4	3	2	2	4	3	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:52425293G>C	uc011bef.1	+	62	10101	c.9840G>C	c.(9838-9840)GAG>GAC	p.E3280D	DNAH1_uc003ddv.2_Missense_Mutation_p.E138D	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3345	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTCTCCTGGAGAACGTGGGCG	0.607													7	17					0	0	0	0	C	52425293	C	C	52425293	3	2	177	1	0	0	0	0	1	0	0	0	4619	933	33	2	10082	2	DNAH1	3	52425293	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	167970	52425293	145597137	57	33331											
ITIH1	3697	broad.mit.edu	37	chr3	52819193	52819193	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagattgtggtggccgggcGcattgctgacaacaaacaga	12	7	14	8	2	0	3	0	1	0	2	0	4	0	3	1	3	3	2	1	3	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:52819193G>A	uc003dfs.2	+	12	1565	c.1541G>A	c.(1540-1542)CGC>CAC	p.R514H	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Missense_Mutation_p.R115H|ITIH1_uc010hmo.1_Missense_Mutation_p.R68H|ITIH1_uc003dfu.2_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	514	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GTGGCCGGGCGCATTGCTGAC	0.572													32	135					0	0	0	0	A	52819193	A	A	52819193	3	1	177	1	0	0	0	0	1	0	0	0	7942	1087	38	1	1587	1	ITIH1	3	52819193	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	393900	52819193	145203237	58	33332											
FLNB	2317	broad.mit.edu	37	chr3	58155432	58155432	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcccaaggcatcctcggaCgccagcaaggtgacctctaa	11	7	9	14	2	1	1	0	1	1	0	4	2	3	2	4	3	1	2	4	3	3	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:58155432C>T	uc003djj.2	+	45	7698	c.7533C>T	c.(7531-7533)GAC>GAT	p.D2511D	FLNB_uc010hne.2_Silent_p.D2542D|FLNB_uc003djk.2_Silent_p.D2500D|FLNB_uc010hnf.2_Silent_p.D2487D|FLNB_uc003djl.2_Silent_p.D2331D|FLNB_uc003djm.2_Silent_p.D2318D|uc003djn.2_Intron	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2511	Interaction with INPPL1.|Filamin 24.|Self-association site, tail (By similarity).|Interaction with FLNA 2.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CATCCTCGGACGCCAGCAAGG	0.592													116	84					0	0	0	0	T	58155432	T	T	58155432	2	4	177	1	0	0	0	0	0	0	0	1	5966	535	19	1		1	FLNB	3	58155432	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	5336239	58155432	139866998	59	33333											
TMF1	7110	broad.mit.edu	37	chr3	69088019	69088019	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcactatccagggcagcctGaatacttcggttcttttctt	7	15	8	11	1	2	1	0	1	2	0	4	1	3	1	2	2	3	3	2	2	3	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:69088019G>A	uc003dnn.2	-	7	2216	c.1969C>T	c.(1969-1971)CAG>TAG	p.Q657*	TMF1_uc011bfx.1_Nonsense_Mutation_p.Q660*	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	657	Potential.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		AGGGCAGCCTGAATACTTCGG	0.353													40	119					0	0	0	0	A	69088019	A	A	69088019	4	1	177	1	0	0	0	0	0	1	0	0	16294	1299	45	2	1356	2	TMF1	3	69088019	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	10932587	69088019	128934411	60	33334											
PDZRN3	23024	broad.mit.edu	37	chr3	73432819	73432819	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtagcgccccatcttcatCtcgctcaccgcgtcgtcgtc	5	10	8	18	6	4	0	2	0	2	0	8	0	4	0	3	0	1	2	3	0	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:73432819C>T	uc003dpl.1	-	10	2994	c.2898G>A	c.(2896-2898)GAG>GAA	p.E966E	PDZRN3_uc011bgh.1_Silent_p.E623E|PDZRN3_uc010hoe.1_Silent_p.E664E|PDZRN3_uc011bgf.1_Silent_p.E683E|PDZRN3_uc011bgg.1_Silent_p.E686E	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	966							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CCATCTTCATCTCGCTCACCG	0.667													55	119					0	0	0	0	T	73432819	T	T	73432819	2	4	177	1	0	0	0	0	0	0	0	1	11763	912	32	2		2	PDZRN3	3	73432819	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	4344800	73432819	124589611	61	33335											
CNTN3	5067	broad.mit.edu	37	chr3	74414719	74414719	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtccatgttaccttacctCtagcaccagggctgctccat	8	11	8	14	0	1	0	0	0	1	0	3	0	3	0	5	2	4	4	5	2	3	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:74414719C>T	uc003dpm.1	-	8	1161	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	361	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TACCTTACCTCTAGCACCAGG	0.498													119	329					0	0	0	0	T	74414719	T	T	74414719	3	4	177	1	0	0	0	0	1	0	0	0	3657	922	32	2	2065	2	CNTN3	3	74414719	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	981900	74414719	123607711	62	33336											
CADM2	253559	broad.mit.edu	37	chr3	85935436	85935436	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacatctggtagtaaacctgCagctgatataagatggttca	14	11	9	7	0	2	2	1	1	1	1	2	2	2	2	1	2	4	5	1	2	6	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:85935436C>A	uc003dqj.2	+	4	1087	c.461C>A	c.(460-462)GCA>GAA	p.A154E	CADM2_uc003dqk.2_Missense_Mutation_p.A163E|CADM2_uc003dql.2_Missense_Mutation_p.A156E	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	154	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		AGTAAACCTGCAGCTGATATA	0.363													21	55					2.39187e-15	2.47971e-15	1	0	A	85935436	A	A	85935436	3	1	177	1	0	0	0	0	1	0	0	0	2579	710	25	4	546	4	CADM2	3	85935436	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	11520717	85935436	112086994	63	33337											
OR5H1	26341	broad.mit.edu	37	chr3	97851704	97851706	+	In_Frame_Del	DEL	CTT	-	-																															tcatctggaaagaccctcacCttcatatcccaatgtactta																										TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:97851704_97851706delCTT	uc011bgt.1	+	1	163_165	c.163_165delCTT	c.(163-165)CTTdel	p.L55del		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						AGACCCTCACCTTCATATCCCAA	0.424													---	---	---								-	97851706	-	-	97851704	7	5	177	1	0	1	0	1	0	0	0	0	11213	681	24	0	165	0	OR5H1	3	97851704	In_Frame_Del	DEL	CTT	TCGA-CV-5442-01A-01D-1512-08	11916268	97851704	100170726	64	33338											
LSAMP	4045	broad.mit.edu	37	chr3	115805246	115805246	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaagtgtaggaaccctcatCatagacatccaccttctgga	12	9	8	12	0	3	1	2	0	1	1	4	3	4	3	3	2	1	2	3	2	4	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:115805246C>T	uc003ebt.2	-	2	813	c.313G>A	c.(313-315)GAT>AAT	p.D105N	LSAMP_uc011bis.1_Missense_Mutation_p.D105N	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	105	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GAACCCTCATCATAGACATCC	0.498													35	67					0	0	0	0	T	115805246	T	T	115805246	3	4	177	1	0	0	0	0	1	0	0	0	9098	826	29	2	727	2	LSAMP	3	115805246	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	17953542	115805246	82217184	65	33339											
ZIC1	7545	broad.mit.edu	37	chr3	147127991	147127991	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcgggcgacgtggccgaacGagacgtgggcctgggcatca	7	4	18	12	7	1	1	1	0	0	1	1	4	1	1	2	4	1	1	2	4	1	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:147127991G>A	uc003ewe.2	+	1	811	c.92G>A	c.(91-93)CGA>CAA	p.R31Q		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	31					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTGGCCGAACGAGACGTGGGC	0.706													11	38					0	0	0	0	A	147127991	A	A	147127991	3	1	177	1	0	0	0	0	1	0	0	0	17745	1058	37	1	94	1	ZIC1	3	147127991	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	31322745	147127991	50894439	66	33340											
CP	1356	broad.mit.edu	37	chr3	148897378	148897378	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agttgaataataagcccatgGaatacaagcagaatcctctg	16	9	8	8	0	1	2	0	1	1	1	2	3	2	3	2	1	3	2	2	1	7	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:148897378G>A	uc003ewy.3	-	15	2879	c.2626C>T	c.(2626-2628)CCA>TCA	p.P876S	CP_uc011bnr.1_RNA|CP_uc003eww.3_Missense_Mutation_p.P28S|CP_uc003ewx.3_Missense_Mutation_p.P657S|CP_uc003ewz.2_Missense_Mutation_p.P876S	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	876	Plastocyanin-like 5.|F5/8 type A 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TAAGCCCATGGAATACAAGCA	0.373													57	34					0	0	0	0	A	148897378	A	A	148897378	3	1	177	1	0	0	0	0	1	0	0	0	3802	1174	41	2	591	2	CP	3	148897378	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	1769387	148897378	49125052	67	33341											
RNF13	11342	broad.mit.edu	37	chr3	149678787	149678787	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaggaagacgacaatgaaGatactgacagtagtgatgca	17	7	12	5	1	0	6	0	4	0	2	0	8	0	7	0	1	2	2	0	1	5	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:149678787G>C	uc003exn.3	+	11	1826	c.1042G>C	c.(1042-1044)GAT>CAT	p.D348H	RNF13_uc003exp.3_Missense_Mutation_p.D348H|RNF13_uc010hvh.2_Missense_Mutation_p.D229H	NM_007282	NP_009213	O43567	RNF13_HUMAN	ring finger protein 13	348	Cytoplasmic (Potential).				protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CGACAATGAAGATACTGACAG	0.423													21	104					0	0	0	0	C	149678787	C	C	149678787	3	2	177	1	0	0	0	0	1	0	0	0	13502	942	33	2	1076	2	RNF13	3	149678787	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	781409	149678787	48343643	68	33342											
MED12L	116931	broad.mit.edu	37	chr3	150911287	150911287	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgacttagattttttctcCtatgcctggagaatcctgtg	8	16	8	9	0	1	3	0	1	1	2	3	4	2	3	3	1	1	0	3	1	3	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:150911287C>A	uc003eyp.2	+	14	2017	c.1979C>A	c.(1978-1980)CCT>CAT	p.P660H	MED12L_uc011bnz.1_Missense_Mutation_p.P520H|MED12L_uc003eyn.2_Missense_Mutation_p.P695H|MED12L_uc003eyo.2_Missense_Mutation_p.P660H	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	660					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATTTTTTCTCCTATGCCTGGA	0.398													32	80					1.30988e-24	1.37744e-24	1	0	A	150911287	A	A	150911287	3	1	177	1	0	0	0	0	1	0	0	0	9482	681	24	4	2033	4	MED12L	3	150911287	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	1232500	150911287	47111143	69	33343											
MYNN	55892	broad.mit.edu	37	chr3	169504251	169504251	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaggatcatactttgagtGaacaggattccatacaaaaa	17	9	8	7	0	1	3	1	2	0	1	2	5	2	5	1	2	3	0	1	2	5	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:169504251G>C	uc003fft.2	+	8	2047	c.1618G>C	c.(1618-1620)GAA>CAA	p.E540Q	MYNN_uc011bpm.1_Missense_Mutation_p.E426Q|MYNN_uc003ffu.2_Missense_Mutation_p.E540Q|MYNN_uc003ffv.2_Missense_Mutation_p.E267Q|MYNN_uc010hwo.2_Missense_Mutation_p.E511Q	NM_018657	NP_061127	Q9NPC7	MYNN_HUMAN	myoneurin	540						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TACTTTGAGTGAACAGGATTC	0.373													59	148					0	0	0	0	C	169504251	C	C	169504251	3	2	177	1	0	0	0	0	1	0	0	0	10114	1291	45	2	1644	2	MYNN	3	169504251	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	18592964	169504251	28518179	70	33344											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			23	85					0	0	0	0	A	178936091	A	A	178936091	3	1	177	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	9431840	178936091	19086339	71	33345											
PSMD2	5708	broad.mit.edu	37	chr3	184020171	184020171	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtagttgtgtgaattacGtgcctgagcctgagaactca	9	14	11	7	1	1	3	1	3	0	1	1	4	1	3	2	0	4	2	2	0	4	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:184020171G>A	uc003fnn.1	+	6	751	c.718G>A	c.(718-720)GTG>ATG	p.V240M	PSMD2_uc011brj.1_Missense_Mutation_p.V81M|PSMD2_uc011brk.1_Missense_Mutation_p.V110M	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	240					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	TGTGAATTACGTGCCTGAGCC	0.403													25	65					0	0	0	0	A	184020171	A	A	184020171	3	1	177	1	0	0	0	0	1	0	0	0	12760	1145	40	1	740	1	PSMD2	3	184020171	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	5084080	184020171	14002259	72	33346											
EIF4G1	1981	broad.mit.edu	37	chr3	184043060	184043060	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctttctccttcctagcccCgaatggatcagtatttcaac	8	13	6	14	1	3	0	2	0	1	0	5	2	4	1	5	1	2	1	5	1	4	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:184043060C>T	uc003fnp.2	+	19	3058	c.2860C>T	c.(2860-2862)CGA>TGA	p.R954*	EIF4G1_uc003fno.1_Nonsense_Mutation_p.R895*|EIF4G1_uc010hxw.1_Nonsense_Mutation_p.R790*|EIF4G1_uc003fnt.2_Nonsense_Mutation_p.R665*|EIF4G1_uc003fnq.2_Nonsense_Mutation_p.R867*|EIF4G1_uc003fnr.2_Nonsense_Mutation_p.R790*|EIF4G1_uc010hxx.2_Nonsense_Mutation_p.R961*|EIF4G1_uc003fns.2_Nonsense_Mutation_p.R914*|EIF4G1_uc010hxy.2_Nonsense_Mutation_p.R961*|EIF4G1_uc003fnv.3_Nonsense_Mutation_p.R955*|EIF4G1_uc003fnu.3_Nonsense_Mutation_p.R954*|EIF4G1_uc003fnw.2_Nonsense_Mutation_p.R961*|EIF4G1_uc003fnx.2_Nonsense_Mutation_p.R759*|EIF4G1_uc003fny.3_Nonsense_Mutation_p.R758*|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	954	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCCTAGCCCCGAATGGATCA	0.522													31	109					0	0	0	0	T	184043060	T	T	184043060	4	4	177	1	0	0	0	0	0	1	0	0	5060	644	23	1	2926	1	EIF4G1	3	184043060	Nonsense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	22889	184043060	13979370	73	33347											
FGFR3	2261	broad.mit.edu	37	chr4	1808852	1808852	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cccgccagcaggagtacctgGacctgtcggcgcctttcgag	6	7	13	15	4	0	0	0	0	0	0	2	3	0	2	5	3	2	2	5	3	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:1808852G>C	uc003gdr.3	+	18	2540	c.2284G>C	c.(2284-2286)GAC>CAC	p.D762H	FGFR3_uc003gdu.2_Missense_Mutation_p.D764H|FGFR3_uc003gds.3_Missense_Mutation_p.D650H|FGFR3_uc003gdq.3_Missense_Mutation_p.G739A	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	762	Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GGAGTACCTGGACCTGTCGGC	0.701		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				3	8					0	0	0	0	C	1808852	C	C	1808852	3	2	177	1	0	0	0	0	1	0	0	0	5899	1174	41	2	2505	2	FGFR3	4	1808852	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08		1808852	189345424	74	33348											
FGFR3	2261	broad.mit.edu	37	chr4	1808924	1808924	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctccagctcctcaggggacGactccgtgtttgcccacgac	6	8	11	16	3	1	0	1	0	0	0	4	3	4	1	4	2	2	3	4	2	0	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:1808924G>A	uc003gdr.3	+	18	2612	c.2356G>A	c.(2356-2358)GAC>AAC	p.D786N	FGFR3_uc003gdu.2_Missense_Mutation_p.D788N|FGFR3_uc003gds.3_Missense_Mutation_p.D674N|FGFR3_uc003gdq.3_Missense_Mutation_p.R763Q	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	786	Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CTCAGGGGACGACTCCGTGTT	0.701		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				10	7					0	0	0	0	A	1808924	A	A	1808924	3	1	177	1	0	0	0	0	1	0	0	0	5899	1058	37	1	2577	1	FGFR3	4	1808924	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	72	1808924	189345352	75	33349											
STIM2	57620	broad.mit.edu	37	chr4	27024254	27024254	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attatctccgcgaaagatatCaagagatgaggtgtccctag	13	10	10	8	2	2	3	1	1	1	2	4	5	3	3	2	1	0	0	2	1	5	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:27024254C>T	uc003gsh.3	+	13	2378	c.2162C>T	c.(2161-2163)TCA>TTA	p.S721L	STIM2_uc003gsg.3_Missense_Mutation_p.S713L|STIM2_uc010iex.2_3'UTR|STIM2_uc010iey.2_3'UTR	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	626	Cytoplasmic (Potential).				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				CGAAAGATATCAAGAGATGAG	0.468													49	76					0	0	0	0	T	27024254	T	T	27024254	3	4	177	1	0	0	0	0	1	0	0	0	15350	838	29	2	1992	2	STIM2	4	27024254	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	25215330	27024254	164130022	76	33350											
TBC1D1	23216	broad.mit.edu	37	chr4	38117541	38117541	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgtttgacatggggctgcGgaaacagtatcggccagaca	11	8	14	8	2	0	2	0	1	0	1	1	4	0	3	1	4	2	3	1	4	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:38117541G>A	uc003gtb.2	+	16	3111	c.2768G>A	c.(2767-2769)CGG>CAG	p.R923Q	TBC1D1_uc011byd.1_Missense_Mutation_p.R1017Q|TBC1D1_uc010ifd.2_Missense_Mutation_p.R710Q	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	923	Rab-GAP TBC.					nucleus	Rab GTPase activator activity			ovary(1)	1						ATGGGGCTGCGGAAACAGTAT	0.403													43	45					0	0	0	0	A	38117541	A	A	38117541	3	1	177	1	0	0	0	0	1	0	0	0	15663	1116	39	1	2826	1	TBC1D1	4	38117541	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	11093287	38117541	153036735	77	33351											
HSD17B13	345275	broad.mit.edu	37	chr4	88231424	88231424	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcagaaagatattgatataCgatggaacaaaaatcatttt	18	12	6	5	1	2	3	2	1	0	2	2	5	2	4	0	1	2	0	0	1	7	6	rs113762141	byFrequency	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:88231424C>T	uc003hqo.2	-	6	846	c.783G>A	c.(781-783)TCG>TCA	p.S261S	HSD17B13_uc010ikk.2_Silent_p.S225S	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	261						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		TATTGATATACGATGGAACAA	0.299													31	79					0	0	0	0	T	88231424	T	T	88231424	2	4	177	1	0	0	0	0	0	0	0	1	7421	523	19	1		1	HSD17B13	4	88231424	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	50113883	88231424	102922852	78	33352											
LARP1B	55132	broad.mit.edu	37	chr4	129043065	129043065	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaacttgattttttgtttGatgaagagattgaacaaata	16	15	8	2	0	0	6	0	4	0	2	0	7	0	6	0	0	2	1	0	0	6	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:129043065G>A	uc003iga.2	+	11	1377	c.1246G>A	c.(1246-1248)GAT>AAT	p.D416N	LARP1B_uc003igc.2_5'UTR|LARP1B_uc003ifz.1_Missense_Mutation_p.D416N|LARP1B_uc003igb.1_Missense_Mutation_p.D131N	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	416							RNA binding				0						TTTTTTGTTTGATGAAGAGAT	0.333													24	34					0	0	0	0	A	129043065	A	A	129043065	3	1	177	1	0	0	0	0	1	0	0	0	8669	1290	45	2	1369	2	LARP1B	4	129043065	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	40811641	129043065	62111211	79	33353											
FGG	2266	broad.mit.edu	37	chr4	155531239	155531239	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcccagtgatatcatggAtttgcaccgtgtctttgcaa	8	15	8	10	1	2	1	1	1	1	0	3	2	3	2	2	1	2	2	2	1	2	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:155531239A>T	uc003ioj.2	-	5	653	c.512T>A	c.(511-513)ATC>AAC	p.I171N	FGG_uc003iog.2_Missense_Mutation_p.I171N|FGG_uc003ioh.2_Missense_Mutation_p.I171N|FGG_uc010ipx.2_Intron|FGG_uc010ipy.2_Intron|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Missense_Mutation_p.I171N	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	171	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GATATCATGGATTTGCACCGT	0.368													63	96					0	0	0	0	T	155531239	T	T	155531239	3	4	177	1	0	0	0	0	1	0	0	0	5902	333	12	5	888	5	FGG	4	155531239	Missense_Mutation	SNP	A	TCGA-CV-5442-01A-01D-1512-08	26488174	155531239	35623037	80	33354											
NPY5R	4889	broad.mit.edu	37	chr4	164271506	164271506	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccactcggaattctgatttCccagtctgggatgactataa	10	12	9	10	1	2	2	0	2	2	0	4	4	3	4	2	2	0	0	2	2	3	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:164271506C>T	uc003iqn.2	+	4	263	c.81C>T	c.(79-81)TTC>TTT	p.F27F		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	27	Extracellular (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				ATTCTGATTTCCCAGTCTGGG	0.393													41	69					0	0	0	0	T	164271506	T	T	164271506	2	4	177	1	0	0	0	0	0	0	0	1	10664	854	30	2		2	NPY5R	4	164271506	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	8740267	164271506	26882770	81	33355											
WDR17	116966	broad.mit.edu	37	chr4	177056386	177056386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagcagtgtacacatcccCgggtaatgaaggtgttattt	12	11	10	8	1	0	1	0	1	0	0	1	1	1	1	2	2	3	4	2	2	5	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:177056386C>T	uc003iuj.2	+	9	1454	c.1298C>T	c.(1297-1299)CCG>CTG	p.P433L	WDR17_uc003iuk.2_Missense_Mutation_p.P409L|WDR17_uc003ium.3_Missense_Mutation_p.P409L|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	433								p.P433L(1)		ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TACACATCCCCGGGTAATGAA	0.338													62	88					0	0	0	0	T	177056386	T	T	177056386	3	4	177	1	0	0	0	0	1	0	0	0	17345	652	23	1	1328	1	WDR17	4	177056386	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	12784880	177056386	14097890	82	33356											
SLC9A3	6550	broad.mit.edu	37	chr5	484663	484663	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccgacagcgacagcatctCggacgtcaggtaggacaggt	10	5	15	11	4	2	0	1	0	1	0	3	4	2	2	1	5	2	2	1	5	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:484663C>T	uc003jbe.2	-	5	1016	c.904G>A	c.(904-906)GAG>AAG	p.E302K	SLC9A3_uc011clx.1_Missense_Mutation_p.E302K	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	302	Helical; Name=I/M7; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GACAGCATCTCGGACGTCAGG	0.632													18	117					0	0	0	0	T	484663	T	T	484663	3	4	177	1	0	0	0	0	1	0	0	0	14777	893	31	1	1652	1	SLC9A3	5	484663	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08		484663	180430597	83	33357											
TRIO	7204	broad.mit.edu	37	chr5	14492748	14492748	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacggcagtgaaggaggatGagatcaacgtctaccaagga	15	5	13	8	2	2	2	1	2	1	1	2	6	2	5	1	4	2	1	1	4	4	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:14492748G>A	uc003jff.2	+	49	7711	c.7705G>A	c.(7705-7707)GAG>AAG	p.E2569K	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2569	SH3 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GAAGGAGGATGAGATCAACGT	0.532													16	145					0	0	0	0	A	14492748	A	A	14492748	3	1	177	1	0	0	0	0	1	0	0	0	16619	1291	45	2	7899	2	TRIO	5	14492748	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	14008085	14492748	166422512	84	33358											
PDZD2	23037	broad.mit.edu	37	chr5	32108096	32108096	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggtgcggctgaacaagctgGaataatagaagctggagatg	13	8	15	5	1	0	3	0	1	0	2	0	5	0	4	0	4	4	3	0	4	6	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:32108096G>A	uc003jhl.2	+	25	8763	c.8375G>A	c.(8374-8376)GGA>GAA	p.G2792E	PDZD2_uc003jhm.2_Missense_Mutation_p.G2792E|PDZD2_uc003jhn.2_RNA|PDZD2_uc003jho.2_RNA	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2792	PDZ 6.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GAACAAGCTGGAATAATAGAA	0.373													33	231					0	0	0	0	A	32108096	A	A	32108096	3	1	177	1	0	0	0	0	1	0	0	0	11755	1174	41	2	8469	2	PDZD2	5	32108096	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	17615348	32108096	148807164	85	33359											
SKP2	6502	broad.mit.edu	37	chr5	36181999	36181999	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtacccttcaactgttaaagGaagcccttcctcatctacag	11	11	6	13	0	3	0	2	0	1	0	4	1	4	1	3	1	4	2	3	1	6	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:36181999G>T	uc003jkc.1	+	10	1323	c.1141G>T	c.(1141-1143)GAA>TAA	p.E381*	SKP2_uc011cou.1_Nonsense_Mutation_p.E167*|SKP2_uc003jkd.2_Intron	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	381					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACTGTTAAAGGAAGCCCTTCC	0.423													86	360					9.61239e-26	1.01372e-25	1	0	T	36181999	T	T	36181999	4	4	177	1	0	0	0	0	0	1	0	0	14427	1175	41	2	1179	2	SKP2	5	36181999	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	4073903	36181999	144733261	86	33360											
C6	729	broad.mit.edu	37	chr5	41160316	41160316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgacacacacacagacattCagtccctgagagggtgggtc	11	7	11	12	0	1	3	1	2	0	2	3	4	2	3	1	2	0	0	1	2	0	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:41160316C>T	uc003jmk.2	-	11	1822	c.1612G>A	c.(1612-1614)GAA>AAA	p.E538K	C6_uc003jml.1_Missense_Mutation_p.E538K	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	538	EGF-like.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CACAGACATTCAGTCCCTGAG	0.473													45	382					0	0	0	0	T	41160316	T	T	41160316	3	4	177	1	0	0	0	0	1	0	0	0	2325	835	29	2	1224	2	C6	5	41160316	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	4978317	41160316	139754944	87	33361											
SNX18	112574	broad.mit.edu	37	chr5	53815217	53815217	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggcctcagccaggcctttGagctggaccagcaggccttc	6	7	13	15	1	1	1	1	1	0	0	2	2	1	2	5	4	3	2	5	4	0	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:53815217G>C	uc003jpj.3	+	1	1625	c.1435G>C	c.(1435-1437)GAG>CAG	p.E479Q	SNX18_uc011cqg.1_Missense_Mutation_p.E479Q|SNX18_uc003jpi.3_Missense_Mutation_p.E479Q	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	479	BAR.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				CCAGGCCTTTGAGCTGGACCA	0.627													20	33					0	0	0	0	C	53815217	C	C	53815217	3	2	177	1	0	0	0	0	1	0	0	0	14953	1291	45	2	1437	2	SNX18	5	53815217	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	12654901	53815217	127100043	88	33362											
DHX29	54505	broad.mit.edu	37	chr5	54585191	54585191	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacaggaggctttttcctttCattttgttgatgtgaaatct	8	19	8	6	0	2	2	1	2	1	0	3	3	3	3	1	2	1	2	1	2	2	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:54585191C>T	uc003jpx.2	-	8	1093	c.973G>A	c.(973-975)GAA>AAA	p.E325K	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	325							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TTTTTCCTTTCATTTTGTTGA	0.333													23	30					0	0	0	0	T	54585191	T	T	54585191	3	4	177	1	0	0	0	0	1	0	0	0	4525	835	29	2	3216	2	DHX29	5	54585191	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	769974	54585191	126330069	89	33363											
SFRS12IP1	285672	broad.mit.edu	37	chr5	64020228	64020228	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttactttctggagaattCagaactattaggtgtagaag	13	13	10	5	0	2	3	1	0	1	3	2	4	2	3	0	2	2	2	0	2	7	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:64020228C>T	uc003jtk.2	-	5	603	c.451G>A	c.(451-453)GAA>AAA	p.E151K		NM_173829	NP_776190	Q8N9Q2	SR1IP_HUMAN	P18SRP protein	151					mRNA processing|RNA splicing		nucleic acid binding|zinc ion binding				0		Lung NSC(167;1.66e-05)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.119)		CTGGAGAATTCAGAACTATTA	0.199													14	27					0	0	0	0	T	64020228	T	T	64020228	3	4	177	1	0	0	0	0	1	0	0	0	14233	835	29	2	20	2	SFRS12IP1	5	64020228	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	9435037	64020228	116895032	90	33364											
GFM2	84340	broad.mit.edu	37	chr5	74018254	74018254	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacaactttgttgtcctggcGagtctgaatttcctgaatgt	9	15	9	8	1	1	2	0	2	1	0	3	3	3	2	2	1	2	1	2	1	4	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:74018254G>A	uc003kdh.1	-	20	2465	c.2161C>T	c.(2161-2163)CGC>TGC	p.R721C	GFM2_uc003kdi.1_Missense_Mutation_p.R674C|GFM2_uc010izj.1_Missense_Mutation_p.R753C|GFM2_uc010izk.1_RNA	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	721					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		TTGTCCTGGCGAGTCTGAATT	0.403													49	106					0	0	0	0	A	74018254	A	A	74018254	3	1	177	1	0	0	0	0	1	0	0	0	6379	1058	37	1	186	1	GFM2	5	74018254	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	9998026	74018254	106897006	91	33365											
ARSB	411	broad.mit.edu	37	chr5	78076243	78076243	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catccaagggccccacacccCagtggccttgggatcacagc	9	5	10	17	0	1	0	1	0	0	0	2	1	2	1	6	3	1	0	6	3	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:78076243C>T	uc003kfq.2	-	8	2865	c.1579G>A	c.(1579-1581)GGG>AGG	p.G527R		NM_000046	NP_000037	P15848	ARSB_HUMAN	arylsulfatase B isoform 1 precursor	527					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			upper_aerodigestive_tract(1)	1		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		CCCCACACCCCAGTGGCCTTG	0.532													41	62					0	0	0	0	T	78076243	T	T	78076243	3	4	177	1	0	0	0	0	1	0	0	0	990	594	21	4	26	4	ARSB	5	78076243	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	4057989	78076243	102839017	92	33366											
GPR98	84059	broad.mit.edu	37	chr5	89981662	89981662	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactaattatcattgccaatGatgatgcatttggaactctt	13	15	6	7	0	2	2	1	2	1	0	2	3	2	3	1	1	4	1	1	1	5	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:89981662G>A	uc003kju.2	+	29	6436	c.6340G>A	c.(6340-6342)GAT>AAT	p.D2114N	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2114	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CATTGCCAATGATGATGCATT	0.428													26	32					0	0	0	0	A	89981662	A	A	89981662	3	1	177	1	0	0	0	0	1	0	0	0	6760	1290	45	2	6454	2	GPR98	5	89981662	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	11905419	89981662	90933598	93	33367											
PCDHA6	56142	broad.mit.edu	37	chr5	140209500	140209500	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctacaacgcgtggctttcGtatgagctgcagcccccggc	6	8	13	14	4	0	1	0	1	0	0	1	1	0	1	2	3	5	5	2	3	3	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:140209500G>A	uc003lho.2	+	1	1851	c.1824G>A	c.(1822-1824)TCG>TCA	p.S608S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.S608S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	608	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGCTTTCGTATGAGCTGC	0.657													43	52					0	0	0	0	A	140209500	A	A	140209500	2	1	177	1	0	0	0	0	0	0	0	1	11582	1132	40	1		1	PCDHA6	5	140209500	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	50227838	140209500	40705760	94	33368											
PCDHA11	56138	broad.mit.edu	37	chr5	140250862	140250862	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcgctgtggtggtcggcaaCgcccactgagggcgcgtgcg	4	6	19	12	6	0	1	0	1	0	0	1	1	0	1	1	5	2	2	1	5	1	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:140250862C>T	uc003lia.2	+	1	3032	c.2174C>T	c.(2173-2175)ACG>ATG	p.T725M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.T725M	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	725	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTCGGCAACGCCCACTGAG	0.667													24	40					0	0	0	0	T	140250862	T	T	140250862	3	4	177	1	0	0	0	0	1	0	0	0	11575	536	19	1	2176	1	PCDHA11	5	140250862	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	41362	140250862	40664398	95	33369											
PCDHB15	56121	broad.mit.edu	37	chr5	140626472	140626472	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcataaccgtgctggtgtcGgacgtcaatgacaacgcccc	10	7	11	13	4	1	1	1	1	0	0	2	2	1	2	3	2	4	2	3	2	3	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:140626472G>A	uc003lje.2	+	1	1326	c.1326G>A	c.(1324-1326)TCG>TCA	p.S442S		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	442	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTGGTGTCGGACGTCAATG	0.587													45	77					0	0	0	0	A	140626472	A	A	140626472	2	1	177	1	0	0	0	0	0	0	0	1	11594	1103	39	1		1	PCDHB15	5	140626472	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	375610	140626472	40288788	96	33370											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720677	140720677	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcgtcatcgtgttgctggcGcacaggctgcggcgctggca	4	10	15	12	5	1	0	1	0	0	0	3	0	1	0	0	4	2	6	0	4	0	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:140720677G>A	uc003ljk.1	+	1	2324	c.2139G>A	c.(2137-2139)GCG>GCA	p.A713A	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Silent_p.A713A|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	713	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTGCTGGCGCACAGGCTGC	0.647													42	81					0	0	0	0	A	140720677	A	A	140720677	2	1	177	1	0	0	0	0	0	0	0	1	11608	1074	38	1		1	PCDHGA2	5	140720677	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	94205	140720677	40194583	97	33371											
TCERG1	10915	broad.mit.edu	37	chr5	145851051	145851051	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtaatatcatttcttgtagGagcccaaagaagaggagatg	15	10	11	5	0	2	3	1	0	1	3	2	5	2	4	1	2	1	2	1	2	5	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:145851051G>A	uc003lob.2	+	9	1553	c.1513G>A	c.(1513-1515)GAG>AAG	p.E505K	TCERG1_uc003loc.2_Missense_Mutation_p.E484K|TCERG1_uc011dbt.1_Missense_Mutation_p.E484K	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	505	Glu-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTTCTTGTAGGAGCCCAAAGA	0.403													42	69					0	0	0	0	A	145851051	A	A	145851051	3	1	177	1	0	0	0	0	1	0	0	0	15751	1188	41	2	1547	2	TCERG1	5	145851051	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	5130374	145851051	35064209	98	33372											
DCTN4	51164	broad.mit.edu	37	chr5	150097909	150097909	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtcacatgggtgaggttctCaactggatttgtaagagtca	11	12	12	6	0	3	2	3	1	1	1	4	3	3	3	0	3	1	2	0	3	2	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:150097909C>G	uc003lsv.2	-	11	1102	c.1000G>C	c.(1000-1002)GAG>CAG	p.E334Q	DCTN4_uc003lsu.2_Missense_Mutation_p.E277Q|DCTN4_uc010jhi.2_Missense_Mutation_p.E341Q	NM_016221	NP_057305	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62) isoform b	334						centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGAGGTTCTCAACTGGATTT	0.483													27	45					0	0	0	0	G	150097909	G	G	150097909	3	3	177	1	0	0	0	0	1	0	0	0	4326	835	29	2	394	2	DCTN4	5	150097909	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	4246858	150097909	30817351	99	33373											
C5orf54	63920	broad.mit.edu	37	chr5	159820802	159820802	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatagccacacggatatcatCactcagattaaagcagcttc	15	9	6	11	1	3	1	3	0	0	1	4	2	3	2	1	1	3	2	1	1	5	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:159820802C>T	uc003lye.1	-	2	2160	c.1696G>A	c.(1696-1698)GAT>AAT	p.D566N	C5orf54_uc003lyf.1_Missense_Mutation_p.D566N	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	566										pancreas(1)	1						cggatatcatcactcagatta	0													10	6					0	0	0	0	T	159820802	T	T	159820802	3	4	177	1	0	0	0	0	1	0	0	0	2320	826	29	2	92	2	C5orf54	5	159820802	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	9722893	159820802	21094458	100	33374											
EIF4E1B	253314	broad.mit.edu	37	chr5	176072440	176072440	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggtatgtggggccgtcgtCaacatccgcaccaaggggga	9	6	16	10	3	1	0	1	0	0	0	3	2	2	1	3	5	1	2	3	5	3	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:176072440C>G	uc010jkf.1	+	8	1121	c.537C>G	c.(535-537)GTC>GTG	p.V179V	TSPAN17_uc003mes.3_5'Flank|TSPAN17_uc003met.2_5'Flank|TSPAN17_uc003meu.2_5'Flank|TSPAN17_uc003mev.2_5'Flank|TSPAN17_uc003mew.2_5'Flank	NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	179					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGCCGTCGTCAACATCCGCA	0.622													19	38					0	0	0	0	G	176072440	G	G	176072440	2	3	177	1	0	0	0	0	0	0	0	1	5053	813	29	2		2	EIF4E1B	5	176072440	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	16251638	176072440	4842820	101	33375											
ZNF354C	30832	broad.mit.edu	37	chr5	178505983	178505983	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaacagagtgttcctataGaaaggatacccaatatgtat	16	10	7	8	0	0	2	0	0	0	2	1	3	1	3	2	1	2	2	2	1	8	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:178505983G>C	uc003mju.2	+	5	665	c.550G>C	c.(550-552)GAA>CAA	p.E184Q		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		TGTTCCTATAGAAAGGATACC	0.353													32	69					0	0	0	0	C	178505983	C	C	178505983	3	2	177	1	0	0	0	0	1	0	0	0	17933	943	33	2	564	2	ZNF354C	5	178505983	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	2433543	178505983	2409277	102	33376											
FARS2	10667	broad.mit.edu	37	chr6	5368981	5368981	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgggcaaatcctaccctCaggacgaccacagcaacctc	11	6	8	16	1	1	0	1	0	0	0	3	2	2	1	4	2	4	3	4	2	3	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:5368981C>T	uc010jnv.1	+	2	514	c.178C>T	c.(178-180)CAG>TAG	p.Q60*	FARS2_uc003mwr.2_Nonsense_Mutation_p.Q60*|FARS2_uc003mws.1_Nonsense_Mutation_p.Q60*	NM_006567	NP_006558	O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2 precursor	60					phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	ATCCTACCCTCAGGACGACCA	0.612													29	48					0	0	0	0	T	5368981	T	T	5368981	4	4	177	1	0	0	0	0	0	1	0	0	5710	827	29	2	180	2	FARS2	6	5368981	Nonsense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08		5368981	165746086	103	33377											
GNL1	2794	broad.mit.edu	37	chr6	30523396	30523396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggttaagcctgcggatatGatgggtcacagactccccgt	8	10	12	11	2	1	2	1	1	0	1	2	3	2	3	3	3	2	1	3	3	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:30523396G>A	uc003nqh.2	-	2	1203	c.175C>T	c.(175-177)CAT>TAT	p.H59Y	GNL1_uc011dmi.1_5'UTR|GNL1_uc011dmj.1_Missense_Mutation_p.H57Y|GNL1_uc011dmk.1_Intron|PRR3_uc003nqi.1_5'Flank|PRR3_uc003nqj.1_5'Flank	NM_005275	NP_005266	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	59					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			ovary(3)	3						CTGCGGATATGATGGGTCACA	0.657													46	96					0	0	0	0	A	30523396	A	A	30523396	3	1	177	1	0	0	0	0	1	0	0	0	6572	1290	45	2	1692	2	GNL1	6	30523396	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	25154415	30523396	140591671	104	33378											
DNAH8	1769	broad.mit.edu	37	chr6	38891905	38891905	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcctttcacagaaaacctGaatcttatttcaatgttggt	12	16	5	8	0	3	2	2	1	1	1	4	2	4	2	2	1	1	1	2	1	5	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:38891905G>A	uc003ooe.1	+	71	10878	c.10278G>A	c.(10276-10278)CTG>CTA	p.L3426L	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CAGAAAACCTGAATCTTATTT	0.348													30	90					0	0	0	0	A	38891905	A	A	38891905	2	1	177	1	0	0	0	0	0	0	0	1	4629	1277	45	2		2	DNAH8	6	38891905	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	8368509	38891905	132223162	105	33379											
PGC	5225	broad.mit.edu	37	chr6	41712219	41712219	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaccaggaagttctggggtgGagtcccgatgctgatctcac	8	9	14	10	1	2	1	1	1	2	0	4	5	3	3	2	4	1	2	2	4	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:41712219G>A	uc003ora.1	-	3	293	c.244C>T	c.(244-246)CCA>TCA	p.P82S		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	82					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			TTCTGGGGTGGAGTCCCGATG	0.617													33	105					0	0	0	0	A	41712219	A	A	41712219	3	1	177	1	0	0	0	0	1	0	0	0	11840	1174	41	2	1259	2	PGC	6	41712219	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	2820314	41712219	129402848	106	33380											
PLA2G7	7941	broad.mit.edu	37	chr6	46678347	46678347	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggctttccatgatcaatgtCaagaatcagactgagagctt	12	12	9	8	0	3	4	3	2	0	3	4	5	4	4	1	1	1	2	1	1	3	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:46678347C>G	uc010jzf.2	-	8	981	c.712G>C	c.(712-714)GAC>CAC	p.D238H	PLA2G7_uc010jzg.1_Missense_Mutation_p.D238H|PLA2G7_uc011dwd.1_Missense_Mutation_p.D193H|PLA2G7_uc011dwe.1_Missense_Mutation_p.D111H	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	238					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			TGATCAATGTCAAGAATCAGA	0.323													54	125					0	0	0	0	G	46678347	G	G	46678347	3	3	177	1	0	0	0	0	1	0	0	0	12064	826	29	2	633	2	PLA2G7	6	46678347	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	4966128	46678347	124436720	107	33381											
PKHD1	5314	broad.mit.edu	37	chr6	51612959	51612959	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatggcaccatagtcaaagTtcttgaaagccaagaagcca	16	7	8	10	0	2	2	1	1	1	1	2	2	2	2	3	1	2	2	3	1	5	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:51612959T>G	uc003pah.1	-	58	9731	c.9455A>C	c.(9454-9456)AAC>ACC	p.N3152T	PKHD1_uc010jzn.1_Missense_Mutation_p.N1135T|PKHD1_uc003pai.2_Missense_Mutation_p.N3152T	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3152	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					ATAGTCAAAGTTCTTGAAAGC	0.418													9	413					0	0	0	0	G	51612959	G	G	51612959	3	3	177	1	0	0	0	0	1	0	0	0	12026	1725	60	5	2848	5	PKHD1	6	51612959	Missense_Mutation	SNP	T	TCGA-CV-5442-01A-01D-1512-08	4934612	51612959	119502108	108	33382											
COL19A1	1310	broad.mit.edu	37	chr6	70840095	70840095	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaatgatgaacatgaagctGgaggcctgaaaggagacaag	17	5	14	5	0	0	5	0	4	0	1	0	8	0	6	1	3	2	1	1	3	5	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:70840095G>A	uc003pfc.1	+	18	1480	c.1363G>A	c.(1363-1365)GGA>AGA	p.G455R	COL19A1_uc010kam.1_Missense_Mutation_p.G351R	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	455	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						ACATGAAGCTGGAGGCCTGAA	0.224													5	55					0	0	0	0	A	70840095	A	A	70840095	3	1	177	1	0	0	0	0	1	0	0	0	3691	1349	47	4	1429	4	COL19A1	6	70840095	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	19227136	70840095	100274972	109	33383											
DDX43	55510	broad.mit.edu	37	chr6	74104684	74104684	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgggtcgttgctagtcggcGaagctcgacagtgtcccgag	6	9	16	10	5	0	0	0	0	0	0	4	3	1	0	1	2	2	3	1	2	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:74104684G>A	uc003pgw.2	+	1	400	c.56G>A	c.(55-57)CGA>CAA	p.R19Q	OOEP_uc003pgv.3_5'UTR|DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	19						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						GCTAGTCGGCGAAGCTCGACA	0.627													49	81					0	0	0	0	A	74104684	A	A	74104684	3	1	177	1	0	0	0	0	1	0	0	0	4380	1058	37	1	58	1	DDX43	6	74104684	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3264589	74104684	97010383	110	33384											
IBTK	25998	broad.mit.edu	37	chr6	82935280	82935280	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatgtataaacacatccatCttcagttaatacaacagtat	18	12	3	8	0	2	0	1	0	1	0	3	0	3	0	1	0	3	3	1	0	8	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:82935280C>T	uc003pjl.1	-	6	1266	c.739G>A	c.(739-741)GAT>AAT	p.D247N	IBTK_uc011dyv.1_Missense_Mutation_p.D247N|IBTK_uc011dyw.1_Missense_Mutation_p.D247N|IBTK_uc010kbi.1_5'UTR|IBTK_uc003pjm.2_Missense_Mutation_p.D247N	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	247					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		ACACATCCATCTTCAGTTAAT	0.383													23	74					0	0	0	0	T	82935280	T	T	82935280	3	4	177	1	0	0	0	0	1	0	0	0	7515	913	32	2	3418	2	IBTK	6	82935280	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	8830596	82935280	88179787	111	33385											
LACE1	246269	broad.mit.edu	37	chr6	108843519	108843519	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggattcagcagaaggactctCcatgtttaccggagaagagg	12	8	13	8	1	2	3	1	0	1	3	3	6	2	5	2	4	2	2	2	4	3	3	rs149085596	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:108843519C>A	uc003psj.2	+	13	1523	c.1337C>A	c.(1336-1338)TCC>TAC	p.S446Y		NM_145315	NP_660358	Q8WV93	LACE1_HUMAN	lactation elevated 1	446							ATP binding			central_nervous_system(1)	1		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		GAAGGACTCTCCATGTTTACC	0.368													4	103					0.00024832	0.00025175	1	0	A	108843519	A	A	108843519	3	1	177	1	0	0	0	0	1	0	0	0	8635	855	30	2	1387	2	LACE1	6	108843519	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	25908239	108843519	62271548	112	33386											
C6orf182	285753	broad.mit.edu	37	chr6	109480484	109480484	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttgcagatgaggcaacatCgtgacccacatatccttcag	11	11	8	11	1	1	3	1	2	0	1	3	3	2	3	2	1	2	2	2	1	2	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:109480484C>T	uc010kdk.2	+	11	1412	c.835C>T	c.(835-837)CGT>TGT	p.R279C	C6orf182_uc003psx.3_Missense_Mutation_p.R279C|C6orf182_uc010kdl.2_Missense_Mutation_p.R279C|C6orf182_uc003psy.3_Missense_Mutation_p.R279C	NM_001083535	NP_001077004	Q8IYX8	CE57L_HUMAN	hypothetical protein LOC285753	279						microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)		GAGGCAACATCGTGACCCACA	0.403													47	108					0	0	0	0	T	109480484	T	T	109480484	3	4	177	1	0	0	0	0	1	0	0	0	2356	884	31	1	865	1	C6orf182	6	109480484	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	636965	109480484	61634583	113	33387											
MICAL1	64780	broad.mit.edu	37	chr6	109769587	109769587	+	Frame_Shift_Del	DEL	T	-	-																															gctcccagcccctgcagctcTgagggttccctgtgggatgt																										TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:109769587delT	uc003ptj.2	-	12	1928	c.1674delA	c.(1672-1674)TCAfs	p.S558fs	MICAL1_uc003ptk.2_Frame_Shift_Del_p.S558fs|MICAL1_uc010kdr.2_Frame_Shift_Del_p.S472fs|MICAL1_uc011eaq.1_Frame_Shift_Del_p.S577fs	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	558	CH.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CCTGCAGCTCTGAGGGTTCCC	0.607													---	---	---								-	109769587	-	-	109769587	7	5	177	1	0	1	0	1	0	0	0	0	9622	1567	55	0	1581	0	MICAL1	6	109769587	Frame_Shift_Del	DEL	T	TCGA-CV-5442-01A-01D-1512-08	289103	109769587	61345480	114	33388											
FAM184A	79632	broad.mit.edu	37	chr6	119338003	119338003	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaattcttccaaagtcttaGaatgggcctcgtttaattga	11	15	7	8	1	2	2	0	1	2	1	4	2	3	2	2	1	0	1	2	1	5	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:119338003G>A	uc003pyj.2	-	5	1787	c.1439C>T	c.(1438-1440)TCT>TTT	p.S480F	FAM184A_uc003pyk.3_Missense_Mutation_p.S360F|FAM184A_uc003pyl.3_Missense_Mutation_p.S360F	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	480	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						CAAAGTCTTAGAATGGGCCTC	0.378													47	113					0	0	0	0	A	119338003	A	A	119338003	3	1	177	1	0	0	0	0	1	0	0	0	5539	942	33	2	2039	2	FAM184A	6	119338003	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	9568416	119338003	51777064	115	33389											
SYNE1	23345	broad.mit.edu	37	chr6	152456262	152456262	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagctgtttgtgatggtcctGaagtatctctgcatcaaggt	9	14	11	7	0	2	2	1	2	1	0	4	2	3	2	1	2	2	4	1	2	4	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:152456262G>A	uc010kiw.2	-	142	26367	c.25765C>T	c.(25765-25767)CAG>TAG	p.Q8589*	SYNE1_uc010kiv.2_Nonsense_Mutation_p.Q3113*|SYNE1_uc003qos.3_Nonsense_Mutation_p.Q3113*|SYNE1_uc003qot.3_Nonsense_Mutation_p.Q8541*|SYNE1_uc003qou.3_Nonsense_Mutation_p.Q8589*|SYNE1_uc003qop.3_Nonsense_Mutation_p.Q774*|SYNE1_uc011eez.1_Nonsense_Mutation_p.Q791*|SYNE1_uc003qoq.3_Nonsense_Mutation_p.Q791*|SYNE1_uc003qor.3_Nonsense_Mutation_p.Q1512*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8589	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGATGGTCCTGAAGTATCTCT	0.383										HNSCC(10;0.0054)			21	86					0	0	0	0	A	152456262	A	A	152456262	4	1	177	1	0	0	0	0	0	1	0	0	15511	1299	45	2	648	2	SYNE1	6	152456262	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	33118259	152456262	18658805	116	33390											
ARID1B	57492	broad.mit.edu	37	chr6	157527778	157527778	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcacattcagactcactttGagagcaagatggaaattcct	14	10	8	9	0	2	3	2	1	0	3	3	5	3	4	1	1	2	2	1	1	2	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:157527778G>A	uc003qqn.2	+	20	5601	c.5449G>A	c.(5449-5451)GAG>AAG	p.E1817K	ARID1B_uc003qqo.2_Missense_Mutation_p.E1777K|ARID1B_uc003qqp.2_Missense_Mutation_p.E1764K	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1822					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GACTCACTTTGAGAGCAAGAT	0.567													37	188					0	0	0	0	A	157527778	A	A	157527778	3	1	177	1	0	0	0	0	1	0	0	0	914	1291	45	2	5581	2	ARID1B	6	157527778	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	5071516	157527778	13587289	117	33391											
INTS1	26173	broad.mit.edu	37	chr7	1542722	1542722	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgcatcccgcttgcgctcaGaaggcaggccggaaggggct	7	5	15	14	4	1	1	1	0	0	1	2	2	2	2	3	5	1	5	3	5	2	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:1542722G>A	uc003skn.2	-	3	265	c.164C>T	c.(163-165)TCT>TTT	p.S55F	INTS1_uc003skq.2_Missense_Mutation_p.S55F	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	55					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTTGCGCTCAGAAGGCAGGCC	0.647													25	55					0	0	0	0	A	1542722	A	A	1542722	3	1	177	1	0	0	0	0	1	0	0	0	7814	942	33	2	6592	2	INTS1	7	1542722	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08		1542722	157595941	118	33392											
HDAC9	9734	broad.mit.edu	37	chr7	18806740	18806740	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgtataggtgatgactctCaaaagtttttttcctcatta	11	17	6	7	0	2	2	2	2	1	0	4	2	3	2	1	1	0	2	1	1	5	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:18806740C>T	uc003suh.2	+	15	2208	c.2167C>T	c.(2167-2169)CAA>TAA	p.Q723*	HDAC9_uc003sue.2_Nonsense_Mutation_p.Q723*|HDAC9_uc011jyd.1_Nonsense_Mutation_p.Q723*|HDAC9_uc003sui.2_Nonsense_Mutation_p.Q726*|HDAC9_uc003suj.2_Nonsense_Mutation_p.Q682*|HDAC9_uc003sua.1_Nonsense_Mutation_p.Q701*	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	723	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TGATGACTCTCAAAAGTTTTT	0.264													5	19					0	0	0	0	T	18806740	T	T	18806740	4	4	177	1	0	0	0	0	0	1	0	0	7053	827	29	2	2285	2	HDAC9	7	18806740	Nonsense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	17264018	18806740	140331923	119	33393											
CPVL	54504	broad.mit.edu	37	chr7	29132252	29132252	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttacctgtataaatcccGtgctacatcgtcctcattga	10	15	5	11	2	1	1	1	1	0	0	4	1	3	1	3	0	3	2	3	0	5	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:29132252G>T	uc003szv.2	-	6	648	c.529C>A	c.(529-531)CGG>AGG	p.R177R	CPVL_uc003szw.2_Silent_p.R177R|CPVL_uc003szx.2_Silent_p.R177R	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	177					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						TATAAATCCCGTGCTACATCG	0.398													62	14					2.54232e-27	2.70444e-27	1	0	T	29132252	T	T	29132252	2	4	177	1	0	0	0	0	0	0	0	1	3850	1144	40	3		3	CPVL	7	29132252	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	10325512	29132252	130006411	120	33394											
GARS	2617	broad.mit.edu	37	chr7	30639566	30639566	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatttaatctctaacaggagCtggcgttacagcccaaagat	13	11	8	9	1	1	1	0	0	1	1	2	2	1	2	1	2	4	2	1	2	5	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:30639566C>T	uc003tbm.2	+	3	685	c.328C>T	c.(328-330)CTG>TTG	p.L110L		NM_002047	NP_002038	P41250	SYG_HUMAN	glycyl-tRNA synthetase	110	WHEP-TRS.				cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)	CTAACAGGAGCTGGCGTTACA	0.383													45	101					0	0	0	0	T	30639566	T	T	30639566	2	4	177	1	0	0	0	0	0	0	0	1	6277	796	28	4		4	GARS	7	30639566	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	1507314	30639566	128499097	121	33395											
SFRP4	6424	broad.mit.edu	37	chr7	37955895	37955895	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actccagggtgcaaatgggcGcgtacatggcacagaggaag	12	5	15	9	2	0	1	0	0	0	1	1	2	1	2	1	4	2	3	1	4	3	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:37955895G>A	uc003tfo.3	-	1	631	c.245C>T	c.(244-246)GCG>GTG	p.A82V		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	82	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						GCAAATGGGCGCGTACATGGC	0.622													59	34					0	0	0	0	A	37955895	A	A	37955895	3	1	177	1	0	0	0	0	1	0	0	0	14228	1087	38	1	819	1	SFRP4	7	37955895	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	7316329	37955895	121182768	122	33396											
VPS41	27072	broad.mit.edu	37	chr7	38812186	38812186	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtctcgttccttggccactAcaacatctctcggactcacg	7	11	8	15	3	3	0	1	0	2	0	7	1	4	1	2	3	2	1	2	3	2	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:38812186A>G	uc003tgy.2	-	13	1090	c.1064T>C	c.(1063-1065)GTA>GCA	p.V355A	VPS41_uc003tgz.2_Missense_Mutation_p.V330A|VPS41_uc010kxn.2_Missense_Mutation_p.V266A	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	355					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						CTTGGCCACTACAACATCTCT	0.408													25	53					0	0	0	0	G	38812186	G	G	38812186	3	3	177	1	0	0	0	0	1	0	0	0	17278	391	14	5	1568	5	VPS41	7	38812186	Missense_Mutation	SNP	A	TCGA-CV-5442-01A-01D-1512-08	856291	38812186	120326477	123	33397											
CALN1	83698	broad.mit.edu	37	chr7	71252799	71252799	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtatctggttggctgcaatCagcatgacactgatgatgaa	12	11	11	7	0	2	4	1	4	1	0	2	4	2	4	0	2	2	5	0	2	3	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:71252799C>G	uc003twa.3	-	6	1148	c.621G>C	c.(619-621)CTG>CTC	p.L207L	CALN1_uc003twb.3_Silent_p.L249L|CALN1_uc003twc.3_Silent_p.L207L	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	207	Helical; Anchor for type IV membrane protein; (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				TGGCTGCAATCAGCATGACAC	0.592													25	51					0	0	0	0	G	71252799	G	G	71252799	2	3	177	1	0	0	0	0	0	0	0	1	2603	813	29	2		2	CALN1	7	71252799	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	32440613	71252799	87885864	124	33398											
MAGI2	9863	broad.mit.edu	37	chr7	77797320	77797320	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcgatgacatagcggtgggTtttgccggctactggaatcc	7	11	14	9	3	0	1	0	1	0	0	2	3	1	2	2	4	3	2	2	4	3	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:77797320T>G	uc003ugx.2	-	15	2763	c.2509A>C	c.(2509-2511)ACC>CCC	p.T837P	MAGI2_uc003ugy.2_Missense_Mutation_p.T823P|MAGI2_uc010ldx.1_Missense_Mutation_p.T430P	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	837	PDZ 4.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TAGCGGTGGGTTTTGCCGGCT	0.552													175	77					0	0	0	0	G	77797320	G	G	77797320	3	3	177	1	0	0	0	0	1	0	0	0	9244	1725	60	5	1890	5	MAGI2	7	77797320	Missense_Mutation	SNP	T	TCGA-CV-5442-01A-01D-1512-08	6544521	77797320	81341343	125	33399											
MAGI2	9863	broad.mit.edu	37	chr7	78131061	78131061	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggataaggctgggagggcatCtcccctgaggcacctgcact	8	7	14	12	0	1	1	0	1	1	0	2	3	1	3	3	5	1	4	3	5	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:78131061C>T	uc003ugx.2	-	5	1052	c.798G>A	c.(796-798)GAG>GAA	p.E266E	MAGI2_uc003ugy.2_Silent_p.E266E|MAGI2_uc011kgr.1_Silent_p.E98E|MAGI2_uc011kgs.1_Silent_p.E103E	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	266	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GGGAGGGCATCTCCCCTGAGG	0.498													38	73					0	0	0	0	T	78131061	T	T	78131061	2	4	177	1	0	0	0	0	0	0	0	1	9244	912	32	2		2	MAGI2	7	78131061	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	333741	78131061	81007602	126	33400											
SEMA3C	10512	broad.mit.edu	37	chr7	80546041	80546041	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggggctgggaagatcctttCacacagatagaacaaataaa	16	8	10	7	0	1	3	1	0	0	3	2	4	2	4	1	3	1	1	1	3	6	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:80546041C>T	uc003uhj.2	-	2	619	c.57G>A	c.(55-57)GTG>GTA	p.V19V	SEMA3C_uc011kgw.1_Silent_p.V37V|SEMA3C_uc011kgx.1_5'UTR	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	19					immune response|response to drug	membrane	receptor activity			ovary(1)	1						AAGATCCTTTCACACAGATAG	0.343													40	128					0	0	0	0	T	80546041	T	T	80546041	2	4	177	1	0	0	0	0	0	0	0	1	14091	813	29	2		2	SEMA3C	7	80546041	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2414980	80546041	78592622	127	33401											
PDK4	5166	broad.mit.edu	37	chr7	95215081	95215081	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaagtttttctatagactCagaagacaaagcctaaaaga	17	10	8	6	0	2	4	1	0	1	4	2	5	2	5	1	1	1	1	1	1	7	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:95215081C>T	uc003uoa.2	-	11	1428	c.1108G>A	c.(1108-1110)GAG>AAG	p.E370K	PDK4_uc003unz.2_Missense_Mutation_p.E158K	NM_002612	NP_002603	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase 4 precursor	370					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity				0	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			TCTATAGACTCAGAAGACAAA	0.378													19	63					0	0	0	0	T	95215081	T	T	95215081	3	4	177	1	0	0	0	0	1	0	0	0	11732	835	29	2	131	2	PDK4	7	95215081	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	14669040	95215081	63923582	128	33402											
LMTK2	22853	broad.mit.edu	37	chr7	97820093	97820093	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caatgccgcacagccgtattCaaacctttccaacttagatg	12	10	6	13	2	1	1	1	0	0	1	2	1	2	1	4	0	4	2	4	0	5	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:97820093C>T	uc003upd.1	+	10	1345	c.1052C>T	c.(1051-1053)TCA>TTA	p.S351L		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	351	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CAGCCGTATTCAAACCTTTCC	0.468													223	170					0	0	0	0	T	97820093	T	T	97820093	3	4	177	1	0	0	0	0	1	0	0	0	8901	838	29	2	1090	2	LMTK2	7	97820093	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2605012	97820093	61318570	129	33403											
PLOD3	8985	broad.mit.edu	37	chr7	100859192	100859192	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctctgccttccctaccctCagtcctgggtccaggtagag	5	11	9	16	0	2	1	1	0	1	1	6	1	6	1	6	2	2	1	6	2	2	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:100859192C>G	uc003uyd.2	-	5	1068	c.612G>C	c.(610-612)CTG>CTC	p.L204L	ZNHIT1_uc003uye.2_5'Flank|ZNHIT1_uc003uyf.2_5'Flank	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	204					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	TCCCTACCCTCAGTCCTGGGT	0.582													13	64					0	0	0	0	G	100859192	G	G	100859192	2	3	177	1	0	0	0	0	0	0	0	1	12158	813	29	2		2	PLOD3	7	100859192	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	3039099	100859192	58279471	130	33404											
PSMC2	5701	broad.mit.edu	37	chr7	102996211	102996211	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gctgcagataagcagacactCcagagtgaacagcctttaca	14	7	9	11	0	0	4	0	1	0	3	1	4	1	4	2	0	5	3	2	0	3	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:102996211C>G	uc003vbs.2	+	4	331	c.261C>G	c.(259-261)CTC>CTG	p.L87L	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011kln.1_Silent_p.L87L|PSMC2_uc011klo.1_Intron	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	87					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						AGCAGACACTCCAGAGTGAAC	0.458													21	35					0	0	0	0	G	102996211	G	G	102996211	2	3	177	1	0	0	0	0	0	0	0	1	12748	842	30	2		2	PSMC2	7	102996211	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2137019	102996211	56142452	131	33405											
RELN	5649	broad.mit.edu	37	chr7	103130201	103130201	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attcagaccttggaagctctCgtcgcagatgcagatggcac	10	9	11	11	2	2	3	1	0	1	3	4	4	2	4	1	2	2	4	1	2	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:103130201C>T	uc003vca.2	-	60	9911	c.9751G>A	c.(9751-9753)GAG>AAG	p.E3251K	RELN_uc010liz.2_Missense_Mutation_p.E3251K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3251	EGF-like 8.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGGAAGCTCTCGTCGCAGATG	0.403													10	33					0	0	0	0	T	103130201	T	T	103130201	3	4	177	1	0	0	0	0	1	0	0	0	13285	893	31	1	655	1	RELN	7	103130201	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	133990	103130201	56008462	132	33406											
RELN	5649	broad.mit.edu	37	chr7	103389927	103389927	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcaaagtcatctctcaggAtaatgctgtcactatgtatt	12	14	7	8	0	5	0	4	0	1	0	6	1	5	1	0	1	1	2	0	1	4	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:103389927A>G	uc003vca.2	-	6	762	c.602T>C	c.(601-603)ATC>ACC	p.I201T	RELN_uc010liz.2_Missense_Mutation_p.I201T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	201					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATCTCTCAGGATAATGCTGTC	0.343													105	78					0	0	0	0	G	103389927	G	G	103389927	3	3	177	1	0	0	0	0	1	0	0	0	13285	333	12	5	10020	5	RELN	7	103389927	Missense_Mutation	SNP	A	TCGA-CV-5442-01A-01D-1512-08	259726	103389927	55748736	133	33407											
AKR1B1	231	broad.mit.edu	37	chr7	134134473	134134473	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccaggggctgtcttaccGcccacgtgtccagaatgttg	8	9	11	13	2	1	1	0	0	1	1	2	1	2	1	4	2	2	2	4	2	3	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:134134473G>A	uc003vrp.1	-	4	502	c.428C>T	c.(427-429)GCG>GTG	p.A143V	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	143					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	CTGTCTTACCGCCCACGTGTC	0.458													158	103					0	0	0	0	A	134134473	A	A	134134473	3	1	177	1	0	0	0	0	1	0	0	0	466	1101	38	1	550	1	AKR1B1	7	134134473	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	30744546	134134473	25004190	134	33408											
MLL3	58508	broad.mit.edu	37	chr7	151896385	151896385	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtgagttccagattttgttgGagccgaggatgaactaagta	11	12	13	5	1	0	3	0	2	0	1	1	6	1	5	2	2	2	3	2	2	3	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:151896385G>C	uc003wla.2	-	27	4471	c.4252C>G	c.(4252-4254)CCA>GCA	p.P1418A	MLL3_uc003wkz.2_Missense_Mutation_p.P479A	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1418					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GATTTTGTTGGAGCCGAGGAT	0.333			N		medulloblastoma								21	58					0	0	0	0	C	151896385	C	C	151896385	3	2	177	1	0	0	0	0	1	0	0	0	9675	1174	41	2	10615	2	MLL3	7	151896385	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	17761912	151896385	7242278	135	33409											
MLL3	58508	broad.mit.edu	37	chr7	151896520	151896520	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctttgtctacttgtatctaGaagatcttttccaaagaaag	12	15	7	7	0	3	3	0	0	3	3	4	3	4	3	1	0	1	2	1	0	6	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:151896520G>C	uc003wla.2	-	27	4336	c.4117C>G	c.(4117-4119)CTA>GTA	p.L1373V	MLL3_uc003wkz.2_Missense_Mutation_p.L434V	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1373					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTTGTATCTAGAAGATCTTTT	0.318			N		medulloblastoma								29	69					0	0	0	0	C	151896520	C	C	151896520	3	2	177	1	0	0	0	0	1	0	0	0	9675	933	33	2	10750	2	MLL3	7	151896520	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	135	151896520	7242143	136	33410											
DPP6	1804	broad.mit.edu	37	chr7	154595624	154595624	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacctccggggactgggaCgtgaccaagatcctagccta	10	7	11	13	2	1	2	1	1	0	1	3	4	3	4	5	3	1	0	5	3	3	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:154595624C>T	uc003wlk.2	+	14	1587	c.1458C>T	c.(1456-1458)GAC>GAT	p.D486D	DPP6_uc003wli.2_Silent_p.D422D|DPP6_uc003wlm.2_Silent_p.D424D|DPP6_uc011kvq.1_Silent_p.D379D	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	486	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GGGACTGGGACGTGACCAAGA	0.557													7	30					0	0	0	0	T	154595624	T	T	154595624	2	4	177	1	0	0	0	0	0	0	0	1	4752	535	19	1		1	DPP6	7	154595624	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2699104	154595624	4543039	137	33411											
MYOM2	9172	broad.mit.edu	37	chr8	2054178	2054178	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggtttaaaatcgaaaccGtgggggatcagtaagtcagg	14	8	14	5	2	2	1	2	0	0	1	3	3	2	2	1	4	1	2	1	4	4	3	rs140995511		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:2054178G>T	uc003wpx.3	+	22	3019	c.2881G>T	c.(2881-2883)GTG>TTG	p.V961L	MYOM2_uc011kwi.1_Missense_Mutation_p.V386L	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	961	Ig-like C2-type 3.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AATCGAAACCGTGGGGGATCA	0.448													16	95					7.26314e-15	7.50866e-15	1	0	T	2054178	T	T	2054178	3	4	177	1	0	0	0	0	1	0	0	0	10145	1145	40	3	2963	3	MYOM2	8	2054178	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08		2054178	144309844	138	33412											
TNKS	8658	broad.mit.edu	37	chr8	9437728	9437728	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggtgctaatgtccacgctCgtgatgatggaggtctcatc	7	12	13	9	2	1	2	1	2	1	0	5	3	2	3	1	3	1	2	1	3	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:9437728C>T	uc003wss.2	+	2	738	c.733C>T	c.(733-735)CGT>TGT	p.R245C	TNKS_uc011kwv.1_Missense_Mutation_p.R245C|TNKS_uc011kww.1_Missense_Mutation_p.R8C	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	245	ANK 1.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		TGTCCACGCTCGTGATGATGG	0.418													69	193					0	0	0	0	T	9437728	T	T	9437728	3	4	177	1	0	0	0	0	1	0	0	0	16385	884	31	1	739	1	TNKS	8	9437728	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	7383550	9437728	136926294	139	33413											
TM2D2	83877	broad.mit.edu	37	chr8	38851142	38851142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaaggcatggcactggactGaagtgtgttccacgtcgctg	8	10	13	10	2	0	1	0	1	0	0	2	2	1	2	1	3	0	4	1	3	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:38851142G>A	uc003xmk.2	-	3	436	c.353C>T	c.(352-354)TCA>TTA	p.S118L	TM2D2_uc003xml.2_Missense_Mutation_p.S75L|TM2D2_uc003xmm.2_Missense_Mutation_p.S75L|TM2D2_uc003xmn.2_Missense_Mutation_p.S75L	NM_078473	NP_510882	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2 isoform a	118						integral to membrane					0		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			GCACTGGACTGAAGTGTGTTC	0.448													26	56					0	0	0	0	A	38851142	A	A	38851142	3	1	177	1	0	0	0	0	1	0	0	0	16030	1294	45	2	299	2	TM2D2	8	38851142	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	29413414	38851142	107512880	140	33414											
PRDM14	63978	broad.mit.edu	37	chr8	70981882	70981882	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcaagggaggcgccatccGgaaggggaaggggggcatgg	10	2	21	8	2	0	0	0	0	0	0	1	3	1	3	2	9	1	2	2	9	3	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:70981882G>A	uc003xym.2	-	2	416	c.214C>T	c.(214-216)CGG>TGG	p.R72W		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	72					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GGCGCCATCCGGAAGGGGAAG	0.652													7	10					0	0	0	0	A	70981882	A	A	70981882	3	1	177	1	0	0	0	0	1	0	0	0	12517	1115	39	1	1529	1	PRDM14	8	70981882	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	32130740	70981882	75382140	141	33415											
HNF4G	3174	broad.mit.edu	37	chr8	76465281	76465281	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttcttaatactagatctCagtctcaagccctgggtcaa	10	14	6	11	0	4	1	3	0	3	1	6	1	4	1	1	1	2	0	1	1	5	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:76465281C>T	uc003yaq.2	+	6	623	c.353C>T	c.(352-354)TCA>TTA	p.S118L	HNF4G_uc003yar.2_Missense_Mutation_p.S155L	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	118					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TACTAGATCTCAGTCTCAAGC	0.348													25	63					0	0	0	0	T	76465281	T	T	76465281	3	4	177	1	0	0	0	0	1	0	0	0	7293	838	29	2	482	2	HNF4G	8	76465281	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	5483399	76465281	69898741	142	33416											
HNF4G	3174	broad.mit.edu	37	chr8	76471076	76471076	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagtaaaaattaagaacatGaggttccaagtgcagatcgg	16	8	10	7	1	0	3	0	1	0	2	2	3	1	3	2	2	2	3	2	2	6	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:76471076G>A	uc003yaq.2	+	9	1056	c.786G>A	c.(784-786)ATG>ATA	p.M262I	HNF4G_uc003yar.2_Missense_Mutation_p.M299I	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	262					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TTAAGAACATGAGGTTCCAAG	0.453													36	71					0	0	0	0	A	76471076	A	A	76471076	3	1	177	1	0	0	0	0	1	0	0	0	7293	1290	45	2	927	2	HNF4G	8	76471076	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	5795	76471076	69892946	143	33417											
RIMS2	9699	broad.mit.edu	37	chr8	105105807	105105807	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caaggactagtagtgcttctCgtttcagcagcacaagctac	11	10	9	11	1	2	0	1	0	1	0	3	1	2	1	0	1	5	6	0	1	5	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:105105807C>T	uc003yls.2	+	21	3071	c.2830C>T	c.(2830-2832)CGT>TGT	p.R944C	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.R1017C|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	398					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TAGTGCTTCTCGTTTCAGCAG	0.423										HNSCC(12;0.0054)			42	111					0	0	0	0	T	105105807	T	T	105105807	3	4	177	1	0	0	0	0	1	0	0	0	13433	899	31	1		1	RIMS2	8	105105807	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	28634731	105105807	41258215	144	33418											
PKHD1L1	93035	broad.mit.edu	37	chr8	110401306	110401306	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acattaacttttttttaattAgatatggtctaaaactggat	14	18	5	4	0	1	1	0	0	1	1	1	2	1	2	0	2	2	0	0	2	6	8			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:110401306A>T	uc003yne.2	+	8	728	c.624_splice	c.e8-2	p.L208_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTTTTAATTAGATATGGTCT	0.294										HNSCC(38;0.096)			43	94					0	0	0	0	T	110401306	T	T	110401306	5	4	177	1	0	0	0	0	0	0	1	0	12027	434	15	5	652	5	PKHD1L1	8	110401306	Splice_Site	SNP	A	TCGA-CV-5442-01A-01D-1512-08	5295499	110401306	35962716	145	33419											
CSMD3	114788	broad.mit.edu	37	chr8	113519017	113519017	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagggaagtttggtgaaaGaataaagcctgaagatcctg	15	9	13	4	0	0	5	0	3	0	2	1	6	1	6	2	2	1	1	2	2	6	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:113519017G>A	uc003ynu.2	-	29	4957	c.4798C>T	c.(4798-4800)CTT>TTT	p.L1600F	CSMD3_uc003yns.2_Missense_Mutation_p.L872F|CSMD3_uc003ynt.2_Missense_Mutation_p.L1560F|CSMD3_uc011lhx.1_Missense_Mutation_p.L1496F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1600	Extracellular (Potential).|CUB 9.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTTGGTGAAAGAATAAAGCCT	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			20	76					0	0	0	0	A	113519017	A	A	113519017	3	1	177	1	0	0	0	0	1	0	0	0	3963	942	33	2	6497	2	CSMD3	8	113519017	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3117711	113519017	32845005	146	33420											
FER1L6	654463	broad.mit.edu	37	chr8	125076810	125076810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaccaaaagatggaaaacCtaaggtcagactaaaatccc	18	5	7	11	0	1	2	1	0	0	2	2	3	2	3	4	2	1	0	4	2	7	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:125076810C>T	uc003yqw.2	+	26	3757	c.3551C>T	c.(3550-3552)CCT>CTT	p.P1184L	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1184	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GATGGAAAACCTAAGGTCAGA	0.453													18	52					0	0	0	0	T	125076810	T	T	125076810	3	4	177	1	0	0	0	0	1	0	0	0	5847	681	24	4	3649	4	FER1L6	8	125076810	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	11557793	125076810	21287212	147	33421											
C8orf33	65265	broad.mit.edu	37	chr8	146278237	146278238	+	Frame_Shift_Ins	INS	-	A	A																															aatggaggcgagaaggcctcINSagagaaactcgccccagaag																										TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:146278237_146278238insA	uc003zfc.3	+	2	326_327	c.272_273insA	c.(271-273)TCAfs	p.S91fs	C8orf33_uc003zfd.2_RNA	NM_023080	NP_075568	Q9H7E9	CH033_HUMAN	hypothetical protein LOC65265	91											0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)		GAGAAGGCCTCAGAGAAACTCG	0.594													---	---	---								A	146278238	A	A	146278237	7	5	177	1	0	1	1	0	0	0	0	0	2433	838	29	0	278	0	C8orf33	8	146278237	Frame_Shift_Ins	INS	-	TCGA-CV-5442-01A-01D-1512-08	21201427	146278237	85785	148	33422											
DOCK8	81704	broad.mit.edu	37	chr9	390558	390558	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtatgcctggttcttctttGagcttctggtgagattcttg	5	18	11	7	0	4	2	0	2	4	1	4	3	4	2	1	2	2	3	1	2	1	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:390558G>C	uc003zgf.2	+	24	3074	c.2962G>C	c.(2962-2964)GAG>CAG	p.E988Q	DOCK8_uc010mgu.2_Missense_Mutation_p.E290Q|DOCK8_uc010mgv.2_Missense_Mutation_p.E888Q|DOCK8_uc010mgw.1_Missense_Mutation_p.E290Q|DOCK8_uc003zgk.2_Missense_Mutation_p.E446Q	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	988					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GTTCTTCTTTGAGCTTCTGGT	0.433													24	83					0	0	0	0	C	390558	C	C	390558	3	2	177	1	0	0	0	0	1	0	0	0	4715	1291	45	2	3056	2	DOCK8	9	390558	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08		390558	140822873	149	33423											
GLIS3	169792	broad.mit.edu	37	chr9	4118651	4118651	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggagagtggctactttccGtgccaaaaaggtaggatggt	12	9	14	6	1	0	1	0	0	0	1	1	3	1	2	2	5	2	2	2	5	5	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:4118651G>A	uc003zhw.1	-	3	556	c.362C>T	c.(361-363)ACG>ATG	p.T121M	GLIS3_uc003zhx.1_Missense_Mutation_p.T276M|GLIS3_uc003zic.1_Missense_Mutation_p.T276M|GLIS3_uc003zie.1_Missense_Mutation_p.T276M|GLIS3_uc010mhh.1_Missense_Mutation_p.T151M|GLIS3_uc003zid.1_Missense_Mutation_p.T54M|GLIS3_uc010mhi.1_Missense_Mutation_p.T83M|GLIS3_uc003zif.1_Missense_Mutation_p.T54M|GLIS3_uc003zig.1_Missense_Mutation_p.T120M|GLIS3_uc003zih.1_Missense_Mutation_p.T54M|GLIS3_uc003zhy.1_Missense_Mutation_p.T54M|GLIS3_uc003zhz.1_Missense_Mutation_p.T54M|GLIS3_uc003zib.1_Missense_Mutation_p.T120M|GLIS3_uc010mhg.1_Missense_Mutation_p.T54M	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	121	Ser-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCTACTTTCCGTGCCAAAAAG	0.557													43	108					0	0	0	0	A	4118651	A	A	4118651	3	1	177	1	0	0	0	0	1	0	0	0	6484	1145	40	1	1997	1	GLIS3	9	4118651	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3728093	4118651	137094780	150	33424											
UHRF2	115426	broad.mit.edu	37	chr9	6460620	6460620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgtcaaggatcttagacCacgagctagaaccattttga	14	10	9	8	1	2	3	1	1	1	2	2	6	2	4	2	1	2	1	2	1	5	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:6460620C>T	uc003zjy.2	+	4	1032	c.692C>T	c.(691-693)CCA>CTA	p.P231L	UHRF2_uc003zjz.2_RNA|UHRF2_uc003zka.1_Missense_Mutation_p.P8L	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains	231	Interaction with PCNP.				cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		GATCTTAGACCACGAGCTAGA	0.368													39	113					0	0	0	0	T	6460620	T	T	6460620	3	4	177	1	0	0	0	0	1	0	0	0	17038	594	21	4	706	4	UHRF2	9	6460620	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2341969	6460620	134752811	151	33425											
UHRF2	115426	broad.mit.edu	37	chr9	6506129	6506129	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatgattcccaatgagattCtgcagactctacttgacctt	10	14	6	11	0	3	4	1	3	2	2	4	5	4	4	2	0	2	1	2	0	2	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:6506129C>G	uc003zjy.2	+	16	2699	c.2359C>G	c.(2359-2361)CTG>GTG	p.L787V	UHRF2_uc003zjz.2_RNA|UHRF2_uc003zkb.2_RNA	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains	787					cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		CAATGAGATTCTGCAGACTCT	0.468													43	117					0	0	0	0	G	6506129	G	G	6506129	3	3	177	1	0	0	0	0	1	0	0	0	17038	912	32	2	2421	2	UHRF2	9	6506129	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	45509	6506129	134707302	152	33426											
C9orf150	286343	broad.mit.edu	37	chr9	12821667	12821667	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccatcagaccccttcagacTtggaccaattcagtgacagc	11	8	8	14	0	3	3	3	1	0	2	3	4	3	4	4	1	1	0	4	1	1	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:12821667T>G	uc003zkw.2	+	2	1298	c.595T>G	c.(595-597)TTG>GTG	p.L199V		NM_203403	NP_981948	Q8IV03	CI150_HUMAN	hypothetical protein LOC286343	202											0				GBM - Glioblastoma multiforme(1;1.64e-13)		CCCTTCAGACTTGGACCAATT	0.512													55	142					0	0	0	0	G	12821667	G	G	12821667	3	3	177	1	0	0	0	0	1	0	0	0	2474	1606	56	5	601	5	C9orf150	9	12821667	Missense_Mutation	SNP	T	TCGA-CV-5442-01A-01D-1512-08	6315538	12821667	128391764	153	33427											
BNC2	54796	broad.mit.edu	37	chr9	16436303	16436303	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgacttcctgggctttttcTtgggtgccaggtcagcactg	4	15	12	10	0	2	1	1	1	1	0	3	1	3	1	2	3	2	2	2	3	0	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:16436303T>A	uc003zml.2	-	6	2029	c.1889A>T	c.(1888-1890)AAG>ATG	p.K630M	BNC2_uc011lmw.1_Missense_Mutation_p.K535M|BNC2_uc003zmm.2_Missense_Mutation_p.K588M|BNC2_uc003zmq.1_Missense_Mutation_p.K644M|BNC2_uc003zmr.1_Missense_Mutation_p.K667M|BNC2_uc003zmp.1_Missense_Mutation_p.K658M|BNC2_uc010mij.1_Missense_Mutation_p.K552M|BNC2_uc011lmv.1_Missense_Mutation_p.K456M|BNC2_uc003zmo.1_Missense_Mutation_p.K552M|BNC2_uc003zmj.2_Missense_Mutation_p.K395M|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.K395M|BNC2_uc003zmn.1_Missense_Mutation_p.K395M	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	630				K -> T (in Ref. 1; BAC03837).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GGGCTTTTTCTTGGGTGCCAG	0.527													40	88					0	0	0	0	A	16436303	A	A	16436303	3	1	177	1	0	0	0	0	1	0	0	0	1478	1609	56	5	1418	5	BNC2	9	16436303	Missense_Mutation	SNP	T	TCGA-CV-5442-01A-01D-1512-08	3614636	16436303	124777128	154	33428											
DCAF12	25853	broad.mit.edu	37	chr9	34107477	34107477	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgatggcatggataccacaGccctgctgggtcacacctcc	8	8	10	15	1	1	0	1	0	0	0	3	2	2	1	4	3	3	2	4	3	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:34107477G>C	uc003ztt.2	-	3	762	c.420C>G	c.(418-420)GGC>GGG	p.G140G		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	140	WD 1.					centrosome|CUL4 RING ubiquitin ligase complex					0						GGATACCACAGCCCTGCTGGG	0.512													67	44					0	0	0	0	C	34107477	C	C	34107477	2	2	177	1	0	0	0	0	0	0	0	1	4280	958	34	4		4	DCAF12	9	34107477	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	17671174	34107477	107105954	155	33429											
PAX5	5079	broad.mit.edu	37	chr9	37015106	37015106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attttggcgtttatattcagCgattttttccaccactttgg	7	19	7	8	2	1	0	1	0	0	0	2	1	2	0	2	2	1	1	2	2	2	10			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:37015106C>T	uc003zzo.1	-	3	746	c.298G>A	c.(298-300)GCT>ACT	p.A100T	PAX5_uc011lpw.1_Missense_Mutation_p.A100T|PAX5_uc011lpx.1_Intron|PAX5_uc011lpy.1_5'UTR|PAX5_uc010mls.1_Missense_Mutation_p.A100T|PAX5_uc011lpz.1_Missense_Mutation_p.A100T|PAX5_uc011lqa.1_5'UTR|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.A100T|PAX5_uc010mlp.1_Missense_Mutation_p.A100T|PAX5_uc011lqc.1_Missense_Mutation_p.A100T|PAX5_uc010mlr.1_Missense_Mutation_p.A100T|PAX5_uc011lqd.1_Intron|PAX5_uc011lqe.1_RNA|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_RNA	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	100	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(32)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		TTATATTCAGCGATTTTTTCC	0.522			T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								138	315					0	0	0	0	T	37015106	T	T	37015106	3	4	177	1	0	0	0	0	1	0	0	0	11536	768	27	1	909	1	PAX5	9	37015106	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2907629	37015106	104198325	156	33430											
APBA1	320	broad.mit.edu	37	chr9	72131087	72131087	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgatgtccttgatggccagcGagatggcatcgcgcttctcc	6	11	12	12	3	1	3	0	2	1	1	4	4	2	3	3	2	1	2	3	2	0	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:72131087G>A	uc004ahh.2	-	2	1316	c.1040C>T	c.(1039-1041)TCG>TTG	p.S347L		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	347					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GATGGCCAGCGAGATGGCATC	0.398													32	76					0	0	0	0	A	72131087	A	A	72131087	3	1	177	1	0	0	0	0	1	0	0	0	756	1059	37	1	1521	1	APBA1	9	72131087	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	35115981	72131087	69082344	157	33431											
TRPM6	140803	broad.mit.edu	37	chr9	77448916	77448916	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggattgtctacttacatCttttccaataaggtctctct	11	16	5	9	0	4	0	0	0	4	0	6	1	5	1	1	2	2	0	1	2	5	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:77448916C>A	uc004ajl.1	-	6	905	c.667G>T	c.(667-669)GAT>TAT	p.D223Y	TRPM6_uc004ajk.1_Missense_Mutation_p.D218Y|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.D223Y|TRPM6_uc010mpd.1_Missense_Mutation_p.D223Y|TRPM6_uc010mpe.1_Missense_Mutation_p.D223Y|TRPM6_uc004ajn.1_Missense_Mutation_p.D223Y	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	223	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CTACTTACATCTTTTCCAATA	0.313													71	54					1.02016e-41	1.09473e-41	1	0	A	77448916	A	A	77448916	3	1	177	1	0	0	0	0	1	0	0	0	16657	913	32	2	5537	2	TRPM6	9	77448916	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	5317829	77448916	63764515	158	33432											
FLJ46321	389763	broad.mit.edu	37	chr9	84609179	84609179	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggaggacagcggaatccGtgtggcacagaagcaggagc	11	5	16	9	2	0	1	0	0	0	1	1	5	1	5	1	5	3	2	1	5	2	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:84609179G>A	uc004amn.2	+	4	3841	c.3794G>A	c.(3793-3795)CGT>CAT	p.R1265H		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1265						integral to membrane					0						AGCGGAATCCGTGTGGCACAG	0.527													92	176					0	0	0	0	A	84609179	A	A	84609179	3	1	177	1	0	0	0	0	1	0	0	0	5964	1145	40	1	3808	1	FLJ46321	9	84609179	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	7160263	84609179	56604252	159	33433											
RASEF	158158	broad.mit.edu	37	chr9	85627423	85627423	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacgcgttttgattgttcttCgagctgaaagaccaaataaa	13	13	8	7	3	1	3	0	2	1	1	2	4	1	3	1	0	2	3	1	0	5	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:85627423C>T	uc004amo.1	-	5	1030	c.769G>A	c.(769-771)GAA>AAA	p.E257K		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	257	Potential.				protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						GATTGTTCTTCGAGCTGAAAG	0.323													11	28					0	0	0	0	T	85627423	T	T	85627423	3	4	177	1	0	0	0	0	1	0	0	0	13133	893	31	1	1505	1	RASEF	9	85627423	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	1018244	85627423	55586008	160	33434											
FAM22F	54754	broad.mit.edu	37	chr9	97082865	97082865	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccttggggccatccttgctGggaaggtacactgaggcaga	8	8	15	10	0	0	2	0	1	0	1	1	3	1	3	3	5	2	3	3	5	2	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:97082865G>A	uc004aup.1	-	5	1014	c.993C>T	c.(991-993)CCC>CCT	p.P331P		NM_017561	NP_060031	A1L443	FA22F_HUMAN	hypothetical protein LOC54754	331	Pro-rich.										0		Acute lymphoblastic leukemia(62;0.136)				CATCCTTGCTGGGAAGGTACA	0.687													5	12					0	0	0	0	A	97082865	A	A	97082865	2	1	177	1	0	0	0	0	0	0	0	1	5573	1335	47	4		4	FAM22F	9	97082865	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	11455442	97082865	44130566	161	33435											
C9orf84	158401	broad.mit.edu	37	chr9	114454011	114454011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taattctctccagaaagtctCatcttttgaactttcacatg	11	16	4	10	0	4	2	2	1	3	1	7	2	5	2	1	0	1	0	1	0	3	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:114454011C>T	uc004bfr.2	-	25	4189	c.4054G>A	c.(4054-4056)GAG>AAG	p.E1352K	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.E1313K|C9orf84_uc010mug.2_Missense_Mutation_p.E1263K	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	1352										ovary(2)	2						CAGAAAGTCTCATCTTTTGAA	0.348													38	110					0	0	0	0	T	114454011	T	T	114454011	3	4	177	1	0	0	0	0	1	0	0	0	2512	835	29	2	288	2	C9orf84	9	114454011	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	17371146	114454011	26759420	162	33436											
STRBP	55342	broad.mit.edu	37	chr9	125921433	125921433	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtctcaaggcctccccagcGcccaaaggtctattacaagt	10	8	8	15	2	2	0	1	0	2	0	4	0	3	0	4	2	2	0	4	2	5	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:125921433G>A	uc004bns.2	-	9	1207	c.777C>T	c.(775-777)GGC>GGT	p.G259G	STRBP_uc004bnt.2_Silent_p.G77G|STRBP_uc004bnu.2_Silent_p.G245G|STRBP_uc004bnv.2_Silent_p.G259G	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	259	DZF.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						CCTCCCCAGCGCCCAAAGGTC	0.393													41	98					0	0	0	0	A	125921433	A	A	125921433	2	1	177	1	0	0	0	0	0	0	0	1	15393	1074	38	1		1	STRBP	9	125921433	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	11467422	125921433	15291998	163	33437											
ASB6	140459	broad.mit.edu	37	chr9	132401583	132401583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggtccaaggggctactctCgtggatctgagccaaggaag	10	7	14	10	1	2	1	0	1	2	0	4	3	3	3	2	5	2	1	2	5	4	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:132401583C>T	uc004byf.1	-	4	575	c.409G>A	c.(409-411)GAG>AAG	p.E137K	ASB6_uc004bye.1_Missense_Mutation_p.E62K|ASB6_uc004byg.1_Intron|ASB6_uc011mbt.1_Missense_Mutation_p.E58K|ASB6_uc010myx.1_Missense_Mutation_p.E137K	NM_017873	NP_060343	Q9NWX5	ASB6_HUMAN	ankyrin repeat and SOCS box-containing 6 isoform	137	ANK 3.				intracellular signal transduction	cytoplasm					0		Ovarian(14;0.00556)				GGGCTACTCTCGTGGATCTGA	0.632													33	75					0	0	0	0	T	132401583	T	T	132401583	3	4	177	1	0	0	0	0	1	0	0	0	1029	893	31	1	868	1	ASB6	9	132401583	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	6480150	132401583	8811848	164	33438											
GPR107	57720	broad.mit.edu	37	chr9	132890983	132890983	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtataaattccgtccggcttCagataacccctacctacaac	12	10	5	14	2	1	1	1	0	0	1	3	1	3	1	5	1	4	2	5	1	7	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:132890983C>T	uc004bze.2	+	19	1876	c.1649C>T	c.(1648-1650)TCA>TTA	p.S550L	GPR107_uc004bzb.2_Missense_Mutation_p.S313L|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.S521L|GPR107_uc004bzd.2_Missense_Mutation_p.S502L|GPR107_uc004bzg.1_5'Flank	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	550						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				CGTCCGGCTTCAGATAACCCC	0.448													66	213					0	0	0	0	T	132890983	T	T	132890983	3	4	177	1	0	0	0	0	1	0	0	0	6661	838	29	2	1723	2	GPR107	9	132890983	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	489400	132890983	8322448	165	33439											
DBH	1621	broad.mit.edu	37	chr9	136518063	136518063	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cacattggcttttcctcaggGagatgtgctcatcacctcct	7	13	8	13	0	3	1	3	0	0	1	5	2	5	1	3	2	1	2	3	2	0	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:136518063G>A	uc004cel.2	+	9	1385	c.1376G>A	c.(1375-1377)GGA>GAA	p.G459E		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	459	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	TTTCCTCAGGGAGATGTGCTC	0.632													30	61					0	0	0	0	A	136518063	A	A	136518063	3	1	177	1	0	0	0	0	1	0	0	0	4267	1188	41	2	1410	2	DBH	9	136518063	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3627080	136518063	4695368	166	33440											
SNAPC4	6621	broad.mit.edu	37	chr9	139278482	139278482	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaagctatttttgcccagtGacctgcaaaagccaaacccc	13	8	7	13	0	0	2	0	1	0	1	0	2	0	2	5	0	5	2	5	0	5	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:139278482G>A	uc004chh.2	-	14	1432	c.1423C>T	c.(1423-1425)CAC>TAC	p.H475Y		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	475	HTH myb-type 3.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		TTTGCCCAGTGACCTGCAAAA	0.552													15	40					0	0	0	0	A	139278482	A	A	139278482	3	1	177	1	0	0	0	0	1	0	0	0	14901	1290	45	2	3022	2	SNAPC4	9	139278482	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	2760419	139278482	1934949	167	33441											
ARHGAP21	57584	broad.mit.edu	37	chr10	24896476	24896476	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaccctcatcatatgattttGatctttctgtctttgagttg	7	19	7	8	0	5	3	2	3	3	0	5	4	5	3	1	0	0	1	1	0	1	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:24896476G>C	uc001isb.2	-	11	3123	c.2636C>G	c.(2635-2637)TCA>TGA	p.S879*	ARHGAP21_uc010qdb.1_RNA|ARHGAP21_uc009xkl.1_Nonsense_Mutation_p.S879*|ARHGAP21_uc010qdc.1_Nonsense_Mutation_p.S714*	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	878					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						ATATGATTTTGATCTTTCTGT	0.383													44	78					0	0	0	0	C	24896476	C	C	24896476	4	2	177	1	0	0	0	0	0	1	0	0	871	1294	45	2	3304	2	ARHGAP21	10	24896476	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08		24896476	110638271	168	33442											
OGDHL	55753	broad.mit.edu	37	chr10	50966434	50966434	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtagggtggggatgctgaCcttgtggacactctgggggt	5	10	20	6	0	1	1	0	1	1	0	1	3	1	3	1	7	1	2	1	7	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:50966434C>A	uc001jie.2	-	2	346	c.204_splice	c.e2+1	p.K68_splice	OGDHL_uc009xog.2_Intron|OGDHL_uc010qgt.1_Splice_Site_p.K68_splice|OGDHL_uc010qgu.1_Intron|OGDHL_uc009xoh.2_Intron	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a						glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGGATGCTGACCTTGTGGACA	0.602													43	70					1.86277e-20	1.94768e-20	1	0	A	50966434	A	A	50966434	5	1	177	1	0	0	0	0	0	0	1	0	10894	521	18	4	2915	4	OGDHL	10	50966434	Splice_Site	SNP	C	TCGA-CV-5442-01A-01D-1512-08	26069958	50966434	84568313	169	33443											
DKK1	22943	broad.mit.edu	37	chr10	54074713	54074713	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgcagaggacgaggagtgcGgcactgatgagtactgcgct	9	6	17	9	4	0	3	0	2	0	1	0	6	0	5	0	3	3	4	0	3	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:54074713G>A	uc001jjr.2	+	2	428	c.274G>A	c.(274-276)GGC>AGC	p.G92S	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor	92	DKK-type Cys-1.				negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						CGAGGAGTGCGGCACTGATGA	0.672											OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	16					0	0	0	0	A	54074713	A	A	54074713	3	1	177	1	0	0	0	0	1	0	0	0	4566	1116	39	1	280	1	DKK1	10	54074713	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3108279	54074713	81460034	170	33444											
PCDH15	65217	broad.mit.edu	37	chr10	55582924	55582924	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggattatgggcacttaagTcatcctcatcagatagaaat	13	11	10	7	0	3	2	3	0	0	2	4	3	4	3	1	3	0	1	1	3	4	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:55582924T>A	uc001jju.1	-	33	4957	c.4562A>T	c.(4561-4563)GAC>GTC	p.D1521V	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.D1518V|PCDH15_uc010qhw.1_Missense_Mutation_p.D1481V|PCDH15_uc010qhx.1_Missense_Mutation_p.D1452V|PCDH15_uc010qhy.1_Missense_Mutation_p.D1528V|PCDH15_uc010qhz.1_Missense_Mutation_p.D1523V|PCDH15_uc010qia.1_Missense_Mutation_p.D1501V|PCDH15_uc010qib.1_Missense_Mutation_p.D1498V	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1521	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GGCACTTAAGTCATCCTCATC	0.373										HNSCC(58;0.16)			4	164					0	0	0	0	A	55582924	A	A	55582924	3	1	177	1	0	0	0	0	1	0	0	0	11565	1667	58	5	2915	5	PCDH15	10	55582924	Missense_Mutation	SNP	T	TCGA-CV-5442-01A-01D-1512-08	1508211	55582924	79951823	171	33445											
DDX50	79009	broad.mit.edu	37	chr10	70706381	70706381	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggccacaaacggagttttGactgagtatttgatagttaa	12	12	12	5	1	0	3	0	3	0	0	0	4	0	4	1	3	1	3	1	3	4	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:70706381G>C	uc001jou.2	+	15	2316	c.2209G>C	c.(2209-2211)GAC>CAC	p.D737H	DDX50_uc010qjc.1_3'UTR	NM_024045	NP_076950	Q9BQ39	DDX50_HUMAN	nucleolar protein GU2	737						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1						ACGGAGTTTTGACTGAGTATT	0.423													55	74					0	0	0	0	C	70706381	C	C	70706381	3	2	177	1	0	0	0	0	1	0	0	0	4385	1290	45	2	2267	2	DDX50	10	70706381	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	15123457	70706381	64828366	172	33446											
SORCS1	114815	broad.mit.edu	37	chr10	108536300	108536300	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtatgctcaccttttggtCttgactgtatgccagaatcc	9	14	8	10	0	2	2	1	1	1	1	3	2	3	2	3	1	2	3	3	1	4	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:108536300C>T	uc001kym.2	-	4	885	c.877G>A	c.(877-879)GAC>AAC	p.D293N	SORCS1_uc001kyl.2_Missense_Mutation_p.D293N|SORCS1_uc009xxs.2_Missense_Mutation_p.D293N|SORCS1_uc001kyn.1_Missense_Mutation_p.D293N|SORCS1_uc001kyo.2_Missense_Mutation_p.D293N	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	293	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACCTTTTGGTCTTGACTGTAT	0.413													7	153					0	0	0	0	T	108536300	T	T	108536300	3	4	177	1	0	0	0	0	1	0	0	0	14994	913	32	2	2955	2	SORCS1	10	108536300	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	37829919	108536300	26998447	173	33447											
SORCS1	114815	broad.mit.edu	37	chr10	108536327	108536327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtatgccagaatccagtcttCttgtttggggtgaaaaagca	11	12	11	7	0	2	2	0	1	2	1	3	2	3	2	2	2	2	3	2	2	4	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:108536327C>T	uc001kym.2	-	4	858	c.850G>A	c.(850-852)GAA>AAA	p.E284K	SORCS1_uc001kyl.2_Missense_Mutation_p.E284K|SORCS1_uc009xxs.2_Missense_Mutation_p.E284K|SORCS1_uc001kyn.1_Missense_Mutation_p.E284K|SORCS1_uc001kyo.2_Missense_Mutation_p.E284K	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	284	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ATCCAGTCTTCTTGTTTGGGG	0.413													57	93					0	0	0	0	T	108536327	T	T	108536327	3	4	177	1	0	0	0	0	1	0	0	0	14994	922	32	2	2982	2	SORCS1	10	108536327	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	27	108536327	26998420	174	33448											
SMC3	9126	broad.mit.edu	37	chr10	112362632	112362632	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagaaatgcaacagctttCaggtggacagaaatccttgg	14	8	12	7	0	1	2	1	0	0	2	2	5	2	3	1	3	3	2	1	3	3	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:112362632C>T	uc001kze.2	+	27	3473	c.3347C>T	c.(3346-3348)TCA>TTA	p.S1116L		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	1116	Ala/Asp-rich (DA-box).				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		CAACAGCTTTCAGGTGGACAG	0.398													29	97					0	0	0	0	T	112362632	T	T	112362632	3	4	177	1	0	0	0	0	1	0	0	0	14848	838	29	2	3453	2	SMC3	10	112362632	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	3826305	112362632	23172115	175	33449											
GPAM	57678	broad.mit.edu	37	chr10	113932772	113932772	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagttgacctttgtgaatttGaatgttccaaaagaagctgt	13	14	9	5	0	0	4	0	3	0	1	1	4	1	4	2	0	1	3	2	0	6	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:113932772G>A	uc009xxy.1	-	8	811	c.613C>T	c.(613-615)CAA>TAA	p.Q205*	GPAM_uc001kzp.2_Nonsense_Mutation_p.Q205*|GPAM_uc001kzq.1_Nonsense_Mutation_p.Q205*	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	205					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		TTGTGAATTTGAATGTTCCAA	0.373													25	54					0	0	0	0	A	113932772	A	A	113932772	4	1	177	1	0	0	0	0	0	1	0	0	6626	1299	45	2	1933	2	GPAM	10	113932772	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	1570140	113932772	21601975	176	33450											
TRPM5	29850	broad.mit.edu	37	chr11	2428395	2428395	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccttcttgaagacccggcgGagcgtcaggctcaggtggct	6	9	14	12	3	3	2	2	1	1	1	4	3	4	3	2	5	1	2	2	5	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:2428395G>A	uc001lwm.3	-	20	3081	c.3072C>T	c.(3070-3072)CTC>CTT	p.L1024L	TRPM5_uc010qxl.1_Silent_p.L1024L|TRPM5_uc009ydn.2_Silent_p.L1026L	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	1024	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		AGACCCGGCGGAGCGTCAGGC	0.662													8	8					0	0	0	0	A	2428395	A	A	2428395	2	1	177	1	0	0	0	0	0	0	0	1	16656	1161	41	2		2	TRPM5	11	2428395	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08		2428395	132578121	177	33451											
OR52I1	390037	broad.mit.edu	37	chr11	4615302	4615302	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttacaaccacacaatggaaAcccctgcctccttcctcctt	10	10	3	18	0	0	0	0	0	0	0	3	1	3	1	7	1	4	0	7	1	4	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:4615302A>T	uc010qyi.1	+	1	34	c.34A>T	c.(34-36)ACC>TCC	p.T12S		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACAATGGAAACCCCTGCCTC	0.473													14	253					0	0	0	0	T	4615302	T	T	4615302	3	4	177	1	0	0	0	0	1	0	0	0	11174	43	2	5	36	5	OR52I1	11	4615302	Missense_Mutation	SNP	A	TCGA-CV-5442-01A-01D-1512-08	2186907	4615302	130391214	178	33452											
RBMXL2	27288	broad.mit.edu	37	chr11	7111451	7111451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagcgtgattcttacagccGgtcaggctgcagggtgccca	7	8	13	13	2	2	1	1	1	1	0	2	1	2	1	3	3	5	2	3	3	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:7111451G>A	uc001mfc.2	+	1	1287	c.1100G>A	c.(1099-1101)CGG>CAG	p.R367Q		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	367	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCTTACAGCCGGTCAGGCTGC	0.652													7	18					0	0	0	0	A	7111451	A	A	7111451	3	1	177	1	0	0	0	0	1	0	0	0	13219	1116	39	1	1102	1	RBMXL2	11	7111451	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	2496149	7111451	127895065	179	33453											
OR10A6	390093	broad.mit.edu	37	chr11	7949483	7949483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtcacagatgtgaggtgagCggcacaggtggaaaaggcct	11	6	17	7	1	1	3	1	2	0	1	1	4	1	4	1	6	1	1	1	6	2	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:7949483C>T	uc010rbh.1	-	1	727	c.727G>A	c.(727-729)GCT>ACT	p.A243T		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTGAGGTGAGCGGCACAGGTG	0.453													31	43					0	0	0	0	T	7949483	T	T	7949483	3	4	177	1	0	0	0	0	1	0	0	0	10948	768	27	1	220	1	OR10A6	11	7949483	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	838032	7949483	127057033	180	33454											
KIF18A	81930	broad.mit.edu	37	chr11	28057782	28057782	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accgttgtaaaatgtctttgTtatcatttggtagtgattct	9	19	8	5	1	3	1	1	1	2	0	3	1	3	1	1	1	0	4	1	1	4	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:28057782T>C	uc001msc.2	-	14	2560	c.2378A>G	c.(2377-2379)AAC>AGC	p.N793S		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	793					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						AATGTCTTTGTTATCATTTGG	0.318													32	40					0	0	0	0	C	28057782	C	C	28057782	3	2	177	1	0	0	0	0	1	0	0	0	8319	1725	60	5	334	5	KIF18A	11	28057782	Missense_Mutation	SNP	T	TCGA-CV-5442-01A-01D-1512-08	20108299	28057782	106948734	181	33455											
OR4C3	256144	broad.mit.edu	37	chr11	48347158	48347158	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatacgtatgtcattggtctGctggtggttgccaacagtgg	8	13	13	7	1	2	0	1	0	1	0	2	0	2	0	1	4	4	3	1	4	4	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:48347158G>T	uc010rhv.1	+	1	666	c.666G>T	c.(664-666)CTG>CTT	p.L222L		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	195	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCATTGGTCTGCTGGTGGTTG	0.502													36	68					6.84511e-11	7.03685e-11	1	0	T	48347158	T	T	48347158	2	4	177	1	0	0	0	0	0	0	0	1	11104	1306	46	4		4	OR4C3	11	48347158	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	20289376	48347158	86659358	182	33456											
POLD3	10714	broad.mit.edu	37	chr11	74351802	74351802	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccattactggcttcttccaGaggaaataaactgccatctc	11	12	6	12	0	2	1	0	0	2	1	5	2	4	2	3	2	3	1	3	2	4	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:74351802G>C	uc001ovf.1	+	12	1467	c.1392G>C	c.(1390-1392)CAG>CAC	p.Q464H	POLD3_uc009yua.1_Missense_Mutation_p.Q358H	NM_006591	NP_006582	Q15054	DPOD3_HUMAN	DNA-directed DNA polymerase delta 3	464					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			kidney(2)|ovary(1)	3	Breast(11;3.21e-06)					GCTTCTTCCAGAGGAAATAAA	0.468													26	50					0	0	0	0	C	74351802	C	C	74351802	3	2	177	1	0	0	0	0	1	0	0	0	12247	933	33	2	1438	2	POLD3	11	74351802	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	26004644	74351802	60654714	183	33457											
TRPC6	7225	broad.mit.edu	37	chr11	101342884	101342884	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atacctcaatttcctggaatGaactgttgatcatggcaatt	12	14	7	8	0	2	2	2	2	0	0	3	3	3	3	2	2	2	2	2	2	5	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:101342884G>A	uc001pgk.3	-	8	2614	c.2189C>T	c.(2188-2190)TCA>TTA	p.S730L	TRPC6_uc009ywy.2_Missense_Mutation_p.S614L|TRPC6_uc009ywz.1_Missense_Mutation_p.S675L	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	730	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TTCCTGGAATGAACTGTTGAT	0.328													64	111					0	0	0	0	A	101342884	A	A	101342884	3	1	177	1	0	0	0	0	1	0	0	0	16650	1294	45	2	630	2	TRPC6	11	101342884	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	26991082	101342884	33663632	184	33458											
FAM55D	54827	broad.mit.edu	37	chr11	114453064	114453064	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaaactttcttgttcttaGaatacatgtgagtgagtgca	13	14	9	5	0	2	4	0	2	2	2	2	4	2	4	0	0	3	2	0	0	5	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:114453064G>A	uc001ppc.2	-	3	957	c.776C>T	c.(775-777)TCT>TTT	p.S259F	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	259						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		CTTGTTCTTAGAATACATGTG	0.398													40	56					0	0	0	0	A	114453064	A	A	114453064	3	1	177	1	0	0	0	0	1	0	0	0	5619	942	33	2	874	2	FAM55D	11	114453064	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	13110180	114453064	20553452	185	33459											
SPATA19	219938	broad.mit.edu	37	chr11	133712412	133712412	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctctattcgatctcgcatGatgtcctctgtcatctcact	6	16	6	13	2	5	1	2	1	4	0	9	2	6	1	1	0	1	2	1	0	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:133712412G>C	uc001qgv.1	-	5	456	c.405C>G	c.(403-405)ATC>ATG	p.I135M		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	135					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		GATCTCGCATGATGTCCTCTG	0.498													55	83					0	0	0	0	C	133712412	C	C	133712412	3	2	177	1	0	0	0	0	1	0	0	0	15070	1280	45	2	106	2	SPATA19	11	133712412	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	19259348	133712412	1294104	186	33460											
PRMT8	56341	broad.mit.edu	37	chr12	3662836	3662836	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatcgaatgctccagtatttCtgactactcagagaagatca	13	11	8	9	1	3	3	2	1	1	2	5	6	4	3	1	0	2	2	1	0	4	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:3662836C>G	uc001qmf.2	+	4	804	c.437C>G	c.(436-438)TCT>TGT	p.S146C	PRMT8_uc009zed.2_Missense_Mutation_p.S137C|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	146					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			TCCAGTATTTCTGACTACTCA	0.418													44	73					0	0	0	0	G	3662836	G	G	3662836	3	3	177	1	0	0	0	0	1	0	0	0	12604	913	32	2	451	2	PRMT8	12	3662836	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08		3662836	130189059	187	33461											
NTF3	4908	broad.mit.edu	37	chr12	5603698	5603698	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactcaccgcgggtcctgctGagcgacagcacccccttgga	8	6	11	16	3	1	1	1	1	0	0	2	3	2	2	4	2	4	2	4	2	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:5603698G>A	uc001qnl.3	+	1	401	c.318G>A	c.(316-318)CTG>CTA	p.L106L	NTF3_uc001qnk.3_Silent_p.L119L	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	106					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						GGGTCCTGCTGAGCGACAGCA	0.627													14	76					0	0	0	0	A	5603698	A	A	5603698	2	1	177	1	0	0	0	0	0	0	0	1	10750	1277	45	2		2	NTF3	12	5603698	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	1940862	5603698	128248197	188	33462											
FAM90A1	55138	broad.mit.edu	37	chr12	8380429	8380429	+	5'Flank	DEL	C	-	-																															ggctggagggccgaggactaCccccgcttctaggtgagagg																										TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:8380429delC	uc001qui.2	-						FAM90A1_uc001quh.2_5'Flank	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138								nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		CCGAGGACTACCCCCGCTTCT	0.607													---	---	---								-	8380429	-	-	8380429	6	5	177	0	1	1	0	1	0	0	0	0	5682	522	18	0		0	FAM90A1	12	8380429	5'Flank	DEL	C	TCGA-CV-5442-01A-01D-1512-08	2776731	8380429	125471466	189	33463											
CLEC6A	93978	broad.mit.edu	37	chr12	8618142	8618142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgctacttcatttccagtGaagagaaggtttggtctaag	10	14	11	6	0	2	2	1	1	1	1	3	3	3	2	1	2	2	3	1	2	4	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:8618142G>A	uc001qum.1	+	4	403	c.286G>A	c.(286-288)GAA>AAA	p.E96K		NM_001007033	NP_001007034	Q6EIG7	CLC6A_HUMAN	dectin-2	96	Extracellular (Potential).|C-type lectin.				defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)	1	Lung SC(5;0.184)					CATTTCCAGTGAAGAGAAGGT	0.423													53	73					0	0	0	0	A	8618142	A	A	8618142	3	1	177	1	0	0	0	0	1	0	0	0	3535	1291	45	2	300	2	CLEC6A	12	8618142	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	237713	8618142	125233753	190	33464											
STRAP	11171	broad.mit.edu	37	chr12	16052888	16052888	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgtgtgagatttagtcctGatggagaactctatgccagt	10	13	11	7	0	1	3	0	2	1	2	2	5	2	3	2	1	2	0	2	1	3	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:16052888G>C	uc001rdc.3	+	8	1180	c.826G>C	c.(826-828)GAT>CAT	p.D276H	STRAP_uc010shw.1_Missense_Mutation_p.D289H|STRAP_uc001rdd.3_Missense_Mutation_p.D182H	NM_007178	NP_009109	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated	276	WD 7.				mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			skin(1)	1		Hepatocellular(102;0.121)				ATTTAGTCCTGATGGAGAACT	0.393													45	76					0	0	0	0	C	16052888	C	C	16052888	3	2	177	1	0	0	0	0	1	0	0	0	15392	1290	45	2	856	2	STRAP	12	16052888	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	7434746	16052888	117799007	191	33465											
ARNTL2	56938	broad.mit.edu	37	chr12	27553552	27553552	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaatggaagaagaaaggaaCagtaagaaagacaacagtaa	23	3	12	3	0	0	4	0	0	0	4	0	7	0	7	0	3	2	2	0	3	9	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:27553552C>A	uc001rht.1	+	10	1023	c.1005C>A	c.(1003-1005)AAC>AAA	p.N335K	ARNTL2_uc001rhw.2_Missense_Mutation_p.N298K|ARNTL2_uc010sjp.1_Missense_Mutation_p.N298K|ARNTL2_uc001rhu.1_Missense_Mutation_p.N321K|ARNTL2_uc009zji.1_Missense_Mutation_p.N301K|ARNTL2_uc001rhv.1_Missense_Mutation_p.N287K|uc001rhx.2_Intron	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	335					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					AAGAAAGGAACAGTAAGAAAG	0.373													3	99					0.004672	0.00472348	1	0	A	27553552	A	A	27553552	3	1	177	1	0	0	0	0	1	0	0	0	970	477	17	4	1043	4	ARNTL2	12	27553552	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	11500664	27553552	106298343	192	33466											
CNTN1	1272	broad.mit.edu	37	chr12	41386958	41386958	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaaatatggaggcagcaaGagcagtggacttaatcccat	15	7	12	7	0	0	1	0	0	0	1	1	4	1	4	1	4	2	3	1	4	4	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:41386958G>A	uc001rmm.1	+	17	2113	c.2000G>A	c.(1999-2001)AGA>AAA	p.R667K	CNTN1_uc001rmn.1_Missense_Mutation_p.R656K	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	667	Fibronectin type-III 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GAGGCAGCAAGAGCAGTGGAC	0.383													63	89					0	0	0	0	A	41386958	A	A	41386958	3	1	177	1	0	0	0	0	1	0	0	0	3655	942	33	2	2062	2	CNTN1	12	41386958	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	13833406	41386958	92464937	193	33467											
RAPGEF3	10411	broad.mit.edu	37	chr12	48137435	48137435	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagggtcaacactgagtggTctggccggcagatgtcatag	9	8	15	9	1	3	2	2	1	1	1	3	2	3	2	1	4	1	2	1	4	2	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:48137435T>G	uc009zkp.2	-	17	2017	c.1577A>C	c.(1576-1578)GAC>GCC	p.D526A	RAPGEF3_uc001rpw.2_5'Flank|RAPGEF3_uc001rpx.2_5'UTR|RAPGEF3_uc010sln.1_Intron|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Missense_Mutation_p.D526A|RAPGEF3_uc001rpz.3_Missense_Mutation_p.D568A	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	526					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		CACTGAGTGGTCTGGCCGGCA	0.627													15	26					0	0	0	0	G	48137435	G	G	48137435	3	3	177	1	0	0	0	0	1	0	0	0	13110	1667	58	5	1112	5	RAPGEF3	12	48137435	Missense_Mutation	SNP	T	TCGA-CV-5442-01A-01D-1512-08	6750477	48137435	85714460	194	33468											
MFSD5	84975	broad.mit.edu	37	chr12	53647820	53647820	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcctccatgacagtgatCgaaaaacaggcactcggaat	13	9	9	10	2	0	2	0	2	0	0	4	4	2	3	2	2	1	1	2	2	3	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:53647820C>A	uc001sci.1	+	2	1392	c.1201C>A	c.(1201-1203)CGA>AGA	p.R401R	MFSD5_uc001sch.1_Silent_p.R508R	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	401					transport	integral to membrane				skin(2)|ovary(1)	3						TGACAGTGATCGAAAAACAGG	0.547													38	69					3.76114e-14	3.87735e-14	1	0	A	53647820	A	A	53647820	2	1	177	1	0	0	0	0	0	0	0	1	9587	876	31	3		3	MFSD5	12	53647820	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	5510385	53647820	80204075	195	33469											
ESPL1	9700	broad.mit.edu	37	chr12	53675381	53675381	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctgacctgtgatctgcttCgaagtcaactctactggact	8	12	8	13	1	3	2	1	2	2	0	4	4	3	3	2	1	3	1	2	1	3	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:53675381C>T	uc001sck.2	+	13	2681	c.2590C>T	c.(2590-2592)CGA>TGA	p.R864*	ESPL1_uc001scj.2_Nonsense_Mutation_p.R539*|ESPL1_uc010soe.1_Nonsense_Mutation_p.R75*	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	864					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						TGATCTGCTTCGAAGTCAACT	0.453													64	100					0	0	0	0	T	53675381	T	T	53675381	4	4	177	1	0	0	0	0	0	1	0	0	5277	876	31	1	2636	1	ESPL1	12	53675381	Nonsense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	27561	53675381	80176514	196	33470											
NEUROD4	58158	broad.mit.edu	37	chr12	55420738	55420738	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cacaagcaacctggtggctgGatgtctccaactgggccctc	8	8	11	14	0	1	0	0	0	1	0	3	1	1	1	3	4	3	2	3	4	3	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:55420738G>C	uc001sgp.3	+	2	893	c.515G>C	c.(514-516)GGA>GCA	p.G172A		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	172					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						CTGGTGGCTGGATGTCTCCAA	0.517													32	55					0	0	0	0	C	55420738	C	C	55420738	3	2	177	1	0	0	0	0	1	0	0	0	10404	1174	41	2	517	2	NEUROD4	12	55420738	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	1745357	55420738	78431157	197	33471											
SNRPF	6636	broad.mit.edu	37	chr12	96254999	96254999	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactaacaggaaagccagtGatggtgaaacttaagtgggg	14	7	15	5	0	0	2	0	2	0	0	0	4	0	4	1	5	3	0	1	5	4	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:96254999G>T	uc001tej.2	+	2	200	c.57G>T	c.(55-57)GTG>GTT	p.V19V		NM_003095	NP_003086	P62306	RUXF_HUMAN	small nuclear ribonucleoprotein polypeptide F	19					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding				0						GAAAGCCAGTGATGGTGAAAC	0.408													42	61					1.47197e-15	1.53035e-15	1	0	T	96254999	T	T	96254999	2	4	177	1	0	0	0	0	0	0	0	1	14932	1277	45	2		2	SNRPF	12	96254999	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	40834261	96254999	37596896	198	33472											
SLC5A8	160728	broad.mit.edu	37	chr12	101587457	101587457	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catttaaaatagtgctgattCcaccttgcatcaccacagcc	12	11	5	13	0	1	1	1	1	0	0	2	1	2	1	4	0	3	2	4	0	3	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:101587457C>T	uc001thz.3	-	5	1028	c.638G>A	c.(637-639)GGA>GAA	p.G213E		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	213	Extracellular (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						AGTGCTGATTCCACCTTGCAT	0.398													73	89					0	0	0	0	T	101587457	T	T	101587457	3	4	177	1	0	0	0	0	1	0	0	0	14735	855	30	2	1238	2	SLC5A8	12	101587457	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	5332458	101587457	32264438	199	33473											
KDM2B	84678	broad.mit.edu	37	chr12	121880818	121880818	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcctgaaaagcttatcttCtttgccaggtttgagctgtc	7	17	8	9	0	2	2	0	2	2	0	4	2	3	2	2	1	3	3	2	1	3	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:121880818C>T	uc001uat.2	-	18	2685	c.2581G>A	c.(2581-2583)GAA>AAA	p.E861K	KDM2B_uc001uaq.2_Missense_Mutation_p.E301K|KDM2B_uc010szy.1_Missense_Mutation_p.E301K|KDM2B_uc001uar.2_Missense_Mutation_p.E452K|KDM2B_uc001uas.2_Missense_Mutation_p.E792K|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_Missense_Mutation_p.E109K|KDM2B_uc010szx.1_Missense_Mutation_p.E109K|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	861					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						AGCTTATCTTCTTTGCCAGGT	0.592													15	15					0	0	0	0	T	121880818	T	T	121880818	3	4	177	1	0	0	0	0	1	0	0	0	8164	922	32	2	1505	2	KDM2B	12	121880818	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	20293361	121880818	11971077	200	33474											
NCOR2	9612	broad.mit.edu	37	chr12	124934366	124934366	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgcgagcactcacattttGatgttctcatgatactgccg	8	12	8	13	3	2	2	2	2	1	0	3	3	2	2	2	0	3	2	2	0	1	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:124934366G>C	uc010tba.1	-	7	927	c.810C>G	c.(808-810)ATC>ATG	p.I270M	NCOR2_uc010tay.1_Missense_Mutation_p.I270M|NCOR2_uc010taz.1_Missense_Mutation_p.I270M|NCOR2_uc010tbb.1_Missense_Mutation_p.I270M|NCOR2_uc010tbc.1_Missense_Mutation_p.I270M|NCOR2_uc001ugj.1_Missense_Mutation_p.I270M|NCOR2_uc001ugk.1_Missense_Mutation_p.I270M	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	270	Interaction with SIN3A/B (By similarity).				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CTCACATTTTGATGTTCTCAT	0.612													17	31					0	0	0	0	C	124934366	C	C	124934366	3	2	177	1	0	0	0	0	1	0	0	0	10290	1280	45	2	6922	2	NCOR2	12	124934366	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3053548	124934366	8917529	201	33475											
NOC4L	79050	broad.mit.edu	37	chr12	132636125	132636125	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctcatggtcctgcctttCatctgtaacctgctgcgccg	4	13	9	15	2	3	0	2	0	1	0	4	0	4	0	4	1	5	3	4	1	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:132636125C>T	uc001ujz.1	+	12	1211	c.1170C>T	c.(1168-1170)TTC>TTT	p.F390F		NM_024078	NP_076983	Q9BVI4	NOC4L_HUMAN	nucleolar complex associated 4 homolog	390	Helical; (Potential).				rRNA processing	integral to membrane|nuclear membrane|nucleolus	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.2e-08)|Epithelial(86;3.34e-07)|all cancers(50;1.97e-05)		TCCTGCCTTTCATCTGTAACC	0.721													12	8					0	0	0	0	T	132636125	T	T	132636125	2	4	177	1	0	0	0	0	0	0	0	1	10569	825	29	2		2	NOC4L	12	132636125	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	7701759	132636125	1215770	202	33476											
FLT1	2321	broad.mit.edu	37	chr13	29008329	29008329	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgtcccagattatgcgttttCcatcagggatcaaagtgtca	10	13	9	9	1	3	1	3	0	0	1	5	2	5	2	2	1	1	1	2	1	2	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr13:29008329C>G	uc001usb.3	-	5	827	c.542G>C	c.(541-543)GGA>GCA	p.G181A	FLT1_uc010aar.1_Missense_Mutation_p.G181A|FLT1_uc001usc.3_Missense_Mutation_p.G181A|FLT1_uc010tdp.1_Missense_Mutation_p.G181A	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	181	Ig-like C2-type 2.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TATGCGTTTTCCATCAGGGAT	0.428													19	76					0	0	0	0	G	29008329	G	G	29008329	3	3	177	1	0	0	0	0	1	0	0	0	5973	855	30	2	3841	2	FLT1	13	29008329	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08		29008329	86161549	203	33477											
DGKH	160851	broad.mit.edu	37	chr13	42830658	42830658	+	RNA	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaaaaactaaggacatgctGagtccaaagtgatttaagta	17	10	9	5	0	0	2	0	2	0	0	1	3	1	3	1	1	2	3	1	1	7	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr13:42830658G>C	uc001uyp.2	+	32		c.4438G>C						Q86XP1	DGKH_HUMAN	Homo sapiens DGKH-1 mRNA for diacylglycerol kinase eta1, complete cds.						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		AGGACATGCTGAGTCCAAAGT	0.244													20	29					0	0	0	0	C	42830658	C	C	42830658	1	2	177	0	1	0	0	0	0	0	0	0	4492	1305	45	2		2	DGKH	13	42830658	RNA	SNP	G	TCGA-CV-5442-01A-01D-1512-08	13822329	42830658	72339220	204	33478											
TM9SF2	9375	broad.mit.edu	37	chr13	100192968	100192968	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gattttttaatctcctctagGaagatgataagatcagatgg	13	14	9	5	0	3	4	1	1	2	3	4	6	3	5	1	2	0	0	1	2	4	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr13:100192968G>C	uc001voj.1	+	8	962	c.829G>C	c.(829-831)GAA>CAA	p.E277Q	TM9SF2_uc010afz.1_Missense_Mutation_p.E112Q	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	277	Lumenal (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					TCTCCTCTAGGAAGATGATAA	0.388													46	69					0	0	0	0	C	100192968	C	C	100192968	3	2	177	1	0	0	0	0	1	0	0	0	16044	1188	41	2	859	2	TM9SF2	13	100192968	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	57362310	100192968	14976910	205	33479											
IRS2	8660	broad.mit.edu	37	chr13	110438062	110438062	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcgtccttggtgtagagggcGatcaggtacttgtgcttggc	5	13	15	8	2	1	1	1	0	0	1	3	2	2	1	1	4	2	3	1	4	2	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr13:110438062G>C	uc001vqv.2	-	1	853	c.339C>G	c.(337-339)ATC>ATG	p.I113M		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	113	PH.				fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			TGTAGAGGGCGATCAGGTACT	0.622													7	18					0	0	0	0	C	110438062	C	C	110438062	3	2	177	1	0	0	0	0	1	0	0	0	7880	1048	37	3	3685	3	IRS2	13	110438062	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	10245094	110438062	4731816	206	33480											
COL4A1	1282	broad.mit.edu	37	chr13	110838797	110838797	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctttgtcaccaatgggaccaGcaggaccatatcctggaggc	10	8	11	12	0	1	0	1	0	0	0	2	3	2	3	4	4	1	1	4	4	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr13:110838797G>A	uc001vqw.3	-	26	1954	c.1832C>T	c.(1831-1833)GCT>GTT	p.A611V	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	611	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AATGGGACCAGCAGGACCATA	0.607													69	75					0	0	0	0	A	110838797	A	A	110838797	3	1	177	1	0	0	0	0	1	0	0	0	3704	971	34	4	3285	4	COL4A1	13	110838797	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	400735	110838797	4331081	207	33481											
TEP1	7011	broad.mit.edu	37	chr14	20856088	20856088	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctgggaaacaggagccaagGggcttggagtgtcctcttcc	8	8	15	10	0	1	0	0	0	1	0	3	3	3	3	3	5	2	2	3	5	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:20856088G>T	uc001vxe.2	-	18	2700	c.2660C>A	c.(2659-2661)CCC>CAC	p.P887H	TEP1_uc010ahk.2_Missense_Mutation_p.P237H|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.P779H	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	887					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGGAGCCAAGGGGCTTGGAGT	0.532													32	71					4.92203e-23	5.1611e-23	1	0	T	20856088	T	T	20856088	3	4	177	1	0	0	0	0	1	0	0	0	15825	1232	43	4	5375	4	TEP1	14	20856088	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08		20856088	86493452	208	33482											
SUPT16H	11198	broad.mit.edu	37	chr14	21829239	21829239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcctgtgttcaggctcacctCcttctctttctcttcagctt	3	17	6	15	0	5	0	3	0	2	0	8	0	6	0	3	1	1	3	3	1	0	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:21829239C>T	uc001wao.2	-	16	2266	c.1927G>A	c.(1927-1929)GAG>AAG	p.E643K	SUPT16H_uc001wan.2_5'Flank	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	643					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		AGGCTCACCTCCTTCTCTTTC	0.368													60	120					0	0	0	0	T	21829239	T	T	21829239	3	4	177	1	0	0	0	0	1	0	0	0	15462	864	30	2	1260	2	SUPT16H	14	21829239	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	973151	21829239	85520301	209	33483											
TM9SF1	10548	broad.mit.edu	37	chr14	24663958	24663958	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcggatctcatacaaagactCagccattcggtccccatcca	11	8	7	15	2	2	1	2	0	1	1	6	2	4	2	4	2	2	0	4	2	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:24663958C>T	uc001wnb.1	-	2	616	c.268G>A	c.(268-270)GAG>AAG	p.E90K	TM9SF1_uc010toa.1_Missense_Mutation_p.E3K|TM9SF1_uc001wna.1_RNA|TM9SF1_uc010tob.1_Missense_Mutation_p.E325K|TM9SF1_uc001wnc.2_Missense_Mutation_p.E90K|TM9SF1_uc001wnd.2_5'Flank	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	90					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		TACAAAGACTCAGCCATTCGG	0.507													174	297					0	0	0	0	T	24663958	T	T	24663958	3	4	177	1	0	0	0	0	1	0	0	0	16043	835	29	2	1615	2	TM9SF1	14	24663958	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2834719	24663958	82685582	210	33484											
TINF2	26277	broad.mit.edu	37	chr14	24710319	24710319	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catccaactcagcacatcctGaagctgtgggcagggacaga	12	6	11	12	0	1	2	1	1	0	1	3	3	3	3	2	2	3	3	2	2	2	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:24710319G>A	uc001woa.3	-	5	853	c.511C>T	c.(511-513)CAG>TAG	p.Q171*	TINF2_uc010alm.2_5'UTR|TINF2_uc001wob.3_Nonsense_Mutation_p.Q171*|TINF2_uc010tof.1_Nonsense_Mutation_p.Q136*|TINF2_uc001woc.3_Intron	NM_001099274	NP_001092744	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	171					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|protein binding|telomeric DNA binding				0				GBM - Glioblastoma multiforme(265;0.0185)		AGCACATCCTGAAGCTGTGGG	0.542									Ataxia_Pancytopenia_syndrome|Congenital_Dyskeratosis				116	137					0	0	0	0	A	24710319	A	A	24710319	4	1	177	1	0	0	0	0	0	1	0	0	15989	1299	45	2	868	2	TINF2	14	24710319	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	46361	24710319	82639221	211	33485											
PRKD1	5587	broad.mit.edu	37	chr14	30098292	30098292	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatactgaaatactcacagaGatatctcctggaaatgcatg	15	10	8	8	0	2	2	1	1	1	1	3	5	2	3	1	1	3	1	1	1	5	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:30098292G>C	uc001wqh.2	-	11	1861	c.1680C>G	c.(1678-1680)ATC>ATG	p.I560M		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	560					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TACTCACAGAGATATCTCCTG	0.313													29	37					0	0	0	0	C	30098292	C	C	30098292	3	2	177	1	0	0	0	0	1	0	0	0	12580	932	33	2	1090	2	PRKD1	14	30098292	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	5387973	30098292	77251248	212	33486											
HECTD1	25831	broad.mit.edu	37	chr14	31614087	31614087	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtgttaccactactccacGaggcatgctttcaacagctt	10	11	8	12	1	1	0	1	0	0	0	2	2	2	0	2	1	5	4	2	1	3	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:31614087G>A	uc001wrc.1	-	16	3046	c.2557C>T	c.(2557-2559)CGT>TGT	p.R853C	HECTD1_uc001wrd.1_Missense_Mutation_p.R368C	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	853					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ACTACTCCACGAGGCATGCTT	0.353													23	28					0	0	0	0	A	31614087	A	A	31614087	3	1	177	1	0	0	0	0	1	0	0	0	7078	1058	37	1	5387	1	HECTD1	14	31614087	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	1515795	31614087	75735453	213	33487											
SSTR1	6751	broad.mit.edu	37	chr14	38678915	38678915	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccattgctgatgagctgctCatgctcagcgtgcccttcct	5	12	10	14	1	2	2	2	2	0	0	3	2	3	2	3	0	6	4	3	0	0	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:38678915C>T	uc001wul.1	+	3	938	c.321C>T	c.(319-321)CTC>CTT	p.L107L	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	107	Helical; Name=2; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	ATGAGCTGCTCATGCTCAGCG	0.577													90	163					0	0	0	0	T	38678915	T	T	38678915	2	4	177	1	0	0	0	0	0	0	0	1	15263	813	29	2		2	SSTR1	14	38678915	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	7064828	38678915	68670625	214	33488											
C14orf135	64430	broad.mit.edu	37	chr14	60591509	60591509	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggcactgttcctgaaaacGatctttacaaagcagttcta	13	11	7	10	1	2	1	0	1	2	0	3	2	3	1	1	1	3	4	1	1	5	5	rs112427833	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:60591509G>A	uc001xer.3	+	8	2440	c.1918G>A	c.(1918-1920)GAT>AAT	p.D640N	C14orf135_uc001xeq.2_Missense_Mutation_p.D640N|C14orf135_uc010apm.2_RNA	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	874						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		TCCTGAAAACGATCTTTACAA	0.398													7	206					0	0	0	0	A	60591509	A	A	60591509	3	1	177	1	0	0	0	0	1	0	0	0	1751	1058	37	1	1944	1	C14orf135	14	60591509	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	21912594	60591509	46758031	215	33489											
NRXN3	9369	broad.mit.edu	37	chr14	79423682	79423682	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaaagccttaagttaacCgtggatgatgatgtggctga	13	10	13	5	1	0	3	0	3	0	0	0	5	0	5	2	3	2	2	2	3	4	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:79423682C>T	uc001xun.2	+	8	1745	c.1254C>T	c.(1252-1254)ACC>ACT	p.T418T	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.T543T	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	791	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TTAAGTTAACCGTGGATGATG	0.493													24	67					0	0	0	0	T	79423682	T	T	79423682	2	4	177	1	0	0	0	0	0	0	0	1	10721	639	23	1		1	NRXN3	14	79423682	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	18832173	79423682	27925858	216	33490											
SLC24A4	123041	broad.mit.edu	37	chr14	92949145	92949145	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatggtcaccttcatcacCgccacgctgtggatcgctgt	6	12	9	14	3	4	0	4	0	0	0	5	1	4	1	3	2	0	2	3	2	0	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:92949145C>T	uc001yak.2	+	13	1350	c.1326C>T	c.(1324-1326)ACC>ACT	p.T442T	SLC24A4_uc001yai.2_Silent_p.T395T|SLC24A4_uc010twm.1_Silent_p.T440T|SLC24A4_uc001yaj.2_Silent_p.T423T|SLC24A4_uc010auj.2_Silent_p.T331T|SLC24A4_uc010twn.1_Silent_p.T215T|SLC24A4_uc001yan.2_Silent_p.T153T	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	459	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CCTTCATCACCGCCACGCTGT	0.522													24	21					0	0	0	0	T	92949145	T	T	92949145	2	4	177	1	0	0	0	0	0	0	0	1	14532	639	23	1		1	SLC24A4	14	92949145	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	13525463	92949145	14400395	217	33491											
CYP46A1	10858	broad.mit.edu	37	chr14	100192929	100192929	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcatggcaaagctgctgcaGaggctggagttccggctggt	7	9	16	9	1	1	1	1	0	0	1	2	2	2	2	1	5	3	7	1	5	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:100192929G>A	uc001ygo.2	+	15	1368	c.1368G>A	c.(1366-1368)CAG>CAA	p.Q456Q	CYP46A1_uc001ygp.2_Silent_p.Q293Q	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	456					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				AGCTGCTGCAGAGGCTGGAGT	0.627													3	1					0	0	0	0	A	100192929	A	A	100192929	2	1	177	1	0	0	0	0	0	0	0	1	4199	933	33	2		2	CYP46A1	14	100192929	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	7243784	100192929	7156611	218	33492											
JAG2	3714	broad.mit.edu	37	chr14	105609968	105609968	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcaggtccctggcagggCtgaaggactgcggcaaagaa	11	4	16	10	1	0	2	0	1	0	1	1	3	1	3	1	6	1	4	1	6	3	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:105609968C>T	uc001yqg.2	-	25	3496	c.3092G>A	c.(3091-3093)AGC>AAC	p.S1031N	JAG2_uc010axf.2_5'UTR|JAG2_uc001yqf.2_Missense_Mutation_p.S435N|JAG2_uc001yqh.2_Missense_Mutation_p.S993N	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	1031	Extracellular (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CCTGGCAGGGCTGAAGGACTG	0.682													6	5					0	0	0	0	T	105609968	T	T	105609968	3	4	177	1	0	0	0	0	1	0	0	0	7974	797	28	4	632	4	JAG2	14	105609968	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	5417039	105609968	1739572	219	33493											
C15orf24	56851	broad.mit.edu	37	chr15	34376648	34376663	+	Frame_Shift_Del	DEL	CATGGTTGGAATTCAG	-	-																															ctcagaaacatcaggcaactCatggttggaattcagcatat																										TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:34376648_34376663delCATGGTTGGAATTCAG	uc001zhm.2	-	5	614_629	c.601_616delCTGAATTCCAACCATG	c.(601-618)CTGAATTCCAACCATGAGfs	p.L201fs	C15orf24_uc001zhn.2_Frame_Shift_Del_p.L84fs	NM_020154	NP_064539	Q9NPA0	CO024_HUMAN	chromosome 15 open reading frame 24 precursor	201_206	Cytoplasmic (Potential).					cytoplasm|integral to membrane	carbohydrate binding|carboxypeptidase activity|purine nucleotide binding				0		all_lung(180;1.76e-08)		all cancers(64;2.02e-17)|GBM - Glioblastoma multiforme(113;2.15e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)		TCAGGCAACTCATGGTTGGAATTCAGCATATTCATT	0.421													---	---	---								-	34376663	-	-	34376648	7	5	177	1	0	1	0	1	0	0	0	0	1792	835	29	0	116	0	C15orf24	15	34376648	Frame_Shift_Del	DEL	CATGGTTGGAATTCAG	TCGA-CV-5442-01A-01D-1512-08		34376648	68154744	220	33494											
PLA2G4E	123745	broad.mit.edu	37	chr15	42285087	42285087	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcctttaccacatgtctccGagcctcaaagatagcaggct	10	10	8	13	1	2	1	1	0	1	1	4	2	3	1	4	1	3	2	4	1	3	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:42285087G>A	uc001zow.1	-	12	1231	c.1231C>T	c.(1231-1233)CGG>TGG	p.R411W	PLA2G4E_uc010udc.1_5'UTR|PLA2G4E_uc001zov.1_Missense_Mutation_p.R64W	NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	428	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		ACATGTCTCCGAGCCTCAAAG	0.572													12	17					0	0	0	0	A	42285087	A	A	42285087	3	1	177	1	0	0	0	0	1	0	0	0	12060	1057	37	1	1320	1	PLA2G4E	15	42285087	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	7908439	42285087	60246305	221	33495											
ZFP106	64397	broad.mit.edu	37	chr15	42734335	42734335	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtggcacagcattcacattCtcatcttgttcaggagacat	10	12	9	10	0	4	1	3	0	2	1	5	2	4	1	0	3	1	3	0	3	0	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:42734335C>T	uc001zpw.2	-	7	3965	c.3630G>A	c.(3628-3630)GAG>GAA	p.E1210E	ZFP106_uc001zpu.2_Silent_p.E395E|ZFP106_uc001zpv.2_Silent_p.E395E|ZFP106_uc001zpx.2_Silent_p.E438E	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	1210						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		CATTCACATTCTCATCTTGTT	0.463													78	115					0	0	0	0	T	42734335	T	T	42734335	2	4	177	1	0	0	0	0	0	0	0	1	17704	912	32	2		2	ZFP106	15	42734335	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	449248	42734335	59797057	222	33496											
TLN2	83660	broad.mit.edu	37	chr15	63125727	63125727	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggatgagaccctggactttGaggaacagatcttggaagct	11	9	13	8	1	1	3	0	2	1	2	1	8	1	7	1	4	2	1	1	4	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:63125727G>C	uc002alb.3	+	52	7027	c.7027G>C	c.(7027-7029)GAG>CAG	p.E2343Q	TLN2_uc002alc.3_Missense_Mutation_p.E736Q|TLN2_uc010uic.1_5'UTR|uc002ale.1_RNA	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	2343	I/LWEQ.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CCTGGACTTTGAGGAACAGAT	0.498													28	111					0	0	0	0	C	63125727	C	C	63125727	3	2	177	1	0	0	0	0	1	0	0	0	16014	1291	45	2	7233	2	TLN2	15	63125727	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	20391392	63125727	39405665	223	33497											
GRAMD2	196996	broad.mit.edu	37	chr15	72455741	72455741	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagttcggcatcttcttaggGcaggcaggaccccagcctgg	7	8	13	13	1	2	0	0	0	2	0	3	1	2	1	3	5	1	4	3	5	1	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:72455741G>A	uc002atq.2	-	10	846	c.822C>T	c.(820-822)TGC>TGT	p.C274C	GRAMD2_uc010bis.2_Silent_p.C274C|GRAMD2_uc010ukh.1_Silent_p.C68C	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	274						integral to membrane					0						TCTTCTTAGGGCAGGCAGGAC	0.542													68	76					0	0	0	0	A	72455741	A	A	72455741	2	1	177	1	0	0	0	0	0	0	0	1	6789	1195	42	4		4	GRAMD2	15	72455741	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	9330014	72455741	30075651	224	33498											
SYNM	23336	broad.mit.edu	37	chr15	99670618	99670618	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaaaggaaaacaaagactGaaatagttgtggagtctaaa	19	7	12	3	0	1	2	0	1	1	1	1	5	1	5	0	3	1	1	0	3	8	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:99670618G>A	uc002bup.2	+	6	2173	c.2053G>A	c.(2053-2055)GAA>AAA	p.E685K	SYNM_uc002buo.2_Missense_Mutation_p.E685K|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	685	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						AACAAAGACTGAAATAGTTGT	0.443													17	20					0	0	0	0	A	99670618	A	A	99670618	3	1	177	1	0	0	0	0	1	0	0	0	15521	1291	45	2	2066	2	SYNM	15	99670618	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	27214877	99670618	2860774	225	33499											
ZNF213	7760	broad.mit.edu	37	chr16	3190831	3190831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcgagaaccggccgagggCggccctgggcccagtggtgg	6	3	20	12	4	0	1	0	0	0	1	0	4	0	1	4	6	2	0	4	6	1	0	rs113065910		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:3190831C>T	uc010uws.1	+	6	1310	c.863C>T	c.(862-864)GCG>GTG	p.A288V	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_3'UTR|ZNF213_uc010bth.2_Missense_Mutation_p.A288V|ZNF213_uc010uwt.1_3'UTR	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	288	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CGGCCGAGGGCGGCCCTGGGC	0.746													12	11					0	0	0	0	T	3190831	T	T	3190831	3	4	177	1	0	0	0	0	1	0	0	0	17836	768	27	1	881	1	ZNF213	16	3190831	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08		3190831	87163922	226	33500											
NPIP	9284	broad.mit.edu	37	chr16	15045778	15045778	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agtgtctgctcactccccttCcaccctcagctccaccctca	6	10	4	21	0	4	0	3	0	1	0	7	0	7	0	6	0	2	2	6	0	0	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:15045778C>T	uc002dcy.3	+	8	949	c.949C>T	c.(949-951)CCA>TCA	p.P317S	NPIP_uc002dcx.3_RNA	NM_006985	NP_008916	Q9UND3	NPIP_HUMAN	nuclear pore complex interacting protein	317	Pro-rich.				mRNA transport|protein transport|transmembrane transport	nuclear membrane|nuclear pore					0						CACTCCCCTTCCACCCTCAGC	0.532													4	63					0	0	0	0	T	15045778	T	T	15045778	3	4	177	1	0	0	0	0	1	0	0	0	10638	855	30	2	979	2	NPIP	16	15045778	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	11854947	15045778	75308975	227	33501											
ACSM2A	123876	broad.mit.edu	37	chr16	20487094	20487094	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcctatggccagacagaaaCggtacctgttcccaggggaa	12	7	11	11	1	0	2	0	0	0	2	2	3	2	3	4	4	2	2	4	4	4	3	rs150888398	byFrequency	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:20487094C>T	uc010bwe.2	+	9	1336	c.1097C>T	c.(1096-1098)ACG>ATG	p.T366M	ACSM2A_uc010vax.1_Missense_Mutation_p.T287M|ACSM2A_uc002dhf.3_Missense_Mutation_p.T366M|ACSM2A_uc002dhg.3_Missense_Mutation_p.T366M|ACSM2A_uc010vay.1_Missense_Mutation_p.T287M|ACSM2A_uc002dhh.3_Translation_Start_Site	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	366					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CAGACAGAAACGGTACCTGTT	0.473													101	172					0	0	0	0	T	20487094	T	T	20487094	3	4	177	1	0	0	0	0	1	0	0	0	183	550	19	1	1123	1	ACSM2A	16	20487094	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	5441316	20487094	69867659	228	33502											
GGA2	23062	broad.mit.edu	37	chr16	23491207	23491207	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcctgctggattctgaaaGactagaaagcccagggttag	12	8	12	9	0	1	3	0	1	1	2	1	4	1	4	2	2	3	2	2	2	4	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:23491207G>C	uc002dlq.2	-	11	1084	c.1008C>G	c.(1006-1008)GTC>GTG	p.V336V	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	336	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		GATTCTGAAAGACTAGAAAGC	0.502													15	22					0	0	0	0	C	23491207	C	C	23491207	2	2	177	1	0	0	0	0	0	0	0	1	6390	956	33	2		2	GGA2	16	23491207	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3004113	23491207	66863546	229	33503											
COG4	25839	broad.mit.edu	37	chr16	70543161	70543161	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtagtccctttgcttgatGaacttgtctaccaccttctc	6	16	7	12	0	2	2	0	2	2	0	4	2	3	2	3	1	3	2	3	1	3	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:70543161G>T	uc002ezc.2	-	7	986	c.975C>A	c.(973-975)TTC>TTA	p.F325L	COG4_uc002ezb.2_5'UTR|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.F325L|COG4_uc002eze.2_5'UTR	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	321					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				TTTGCTTGATGAACTTGTCTA	0.483													45	77					8.20599e-20	8.55567e-20	1	0	T	70543161	T	T	70543161	3	4	177	1	0	0	0	0	1	0	0	0	3675	1281	45	2	1446	2	COG4	16	70543161	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	47051954	70543161	19811592	230	33504											
AP1G1	164	broad.mit.edu	37	chr16	71798596	71798596	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttgaatcatcatcatttcGtcctaaaattcttaataacc	14	15	2	10	1	4	1	3	1	1	0	6	1	5	1	2	0	1	0	2	0	5	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:71798596G>A	uc010cgg.2	-	8	1086	c.772C>T	c.(772-774)CGA>TGA	p.R258*	AP1G1_uc002fba.2_Nonsense_Mutation_p.R261*|AP1G1_uc002fbb.2_Nonsense_Mutation_p.R281*|AP1G1_uc010vmg.1_RNA	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	258					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				TCATCATTTCGTCCTAAAATT	0.328													17	38					0	0	0	0	A	71798596	A	A	71798596	4	1	177	1	0	0	0	0	0	1	0	0	732	1153	40	1	1760	1	AP1G1	16	71798596	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	1255435	71798596	18556157	231	33505											
CA5A	763	broad.mit.edu	37	chr16	87970028	87970028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaccaagaaggagaaagctGaggtcttccaagtgttcctc	13	8	10	10	0	1	3	0	1	1	2	4	4	3	3	3	2	2	2	3	2	5	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:87970028G>A	uc002fkn.1	-	1	85	c.29C>T	c.(28-30)TCA>TTA	p.S10L		NM_001739	NP_001730	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial precursor	10					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0513)		GGAGAAAGCTGAGGTCTTCCA	0.542													63	82					0	0	0	0	A	87970028	A	A	87970028	3	1	177	1	0	0	0	0	1	0	0	0	2531	1294	45	2	916	2	CA5A	16	87970028	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	16171432	87970028	2384725	232	33506											
NLGN2	57555	broad.mit.edu	37	chr17	7320306	7320306	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaccaagcccaatcgcttcGaggaggtggtgtggagcaaa	12	6	13	10	2	0	0	0	0	0	0	2	3	0	2	2	4	2	2	2	4	3	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:7320306G>A	uc002ggt.1	+	7	1769	c.1696G>A	c.(1696-1698)GAG>AAG	p.E566K		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	566	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				CAATCGCTTCGAGGAGGTGGT	0.597													24	21					0	0	0	0	A	7320306	A	A	7320306	3	1	177	1	0	0	0	0	1	0	0	0	10516	1059	37	1	1722	1	NLGN2	17	7320306	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08		7320306	73874904	233	33507											
MYH10	4628	broad.mit.edu	37	chr17	8411946	8411946	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgccttttcttcctcttcaGccagctgagaggaacactca	8	12	7	14	1	4	1	2	1	2	1	6	3	5	2	3	1	3	1	3	1	1	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:8411946G>T	uc002gll.2	-	24	3143	c.3047C>A	c.(3046-3048)GCT>GAT	p.A1016D	MYH10_uc002glm.2_Missense_Mutation_p.A1047D|MYH10_uc010cnx.2_Missense_Mutation_p.A1025D	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1016	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TTCCTCTTCAGCCAGCTGAGA	0.413													80	119					5.41795e-27	5.74679e-27	1	0	T	8411946	T	T	8411946	3	4	177	1	0	0	0	0	1	0	0	0	10083	971	34	4	2955	4	MYH10	17	8411946	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	1091640	8411946	72783264	234	33508											
WDR16	146845	broad.mit.edu	37	chr17	9532073	9532073	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacagggagctgctgcggatCaccgtgcccaacatgacctg	10	6	12	13	2	1	1	1	1	0	0	1	3	1	3	3	2	6	2	3	2	2	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:9532073C>T	uc002gly.2	+	9	1179	c.1110C>T	c.(1108-1110)ATC>ATT	p.I370I	WDR16_uc002glz.2_Silent_p.I302I|WDR16_uc010coc.2_Silent_p.I380I	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	370						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TGCTGCGGATCACCGTGCCCA	0.542													27	40					0	0	0	0	T	9532073	T	T	9532073	2	4	177	1	0	0	0	0	0	0	0	1	17344	816	29	2		2	WDR16	17	9532073	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	1120127	9532073	71663137	235	33509											
PRPSAP2	5636	broad.mit.edu	37	chr17	18769186	18769186	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaattagaaaccaagatgAacataaccaaaggtggtctg	17	8	9	7	0	1	4	0	2	1	2	1	4	1	4	2	2	3	0	2	2	7	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:18769186A>T	uc002gup.1	+	3	251	c.40A>T	c.(40-42)AAC>TAC	p.N14Y	PRPSAP2_uc002guo.1_5'UTR|PRPSAP2_uc010vyi.1_Missense_Mutation_p.N2Y|PRPSAP2_uc010vyj.1_5'UTR|PRPSAP2_uc010vyk.1_Missense_Mutation_p.N2Y	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	14					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1						AACCAAGATGAACATAACCAA	0.348													16	31					0	0	0	0	T	18769186	T	T	18769186	3	4	177	1	0	0	0	0	1	0	0	0	12644	246	9	5	42	5	PRPSAP2	17	18769186	Missense_Mutation	SNP	A	TCGA-CV-5442-01A-01D-1512-08	9237113	18769186	62426024	236	33510											
TMIGD1	388364	broad.mit.edu	37	chr17	28644217	28644217	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctagagtacttacagagctGtttcactgtgagggtcttta	9	14	10	8	0	2	3	1	1	1	2	2	3	2	3	1	1	3	3	1	1	4	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:28644217G>C	uc002hfa.1	-	6	852	c.779C>G	c.(778-780)ACA>AGA	p.T260R	TMIGD1_uc010csh.1_3'UTR	NM_206832	NP_996663	Q6UXZ0	TMIG1_HUMAN	transmembrane and immunoglobulin domain	260	Cytoplasmic (Potential).					integral to membrane					0						TTACAGAGCTGTTTCACTGTG	0.423													31	75					0	0	0	0	C	28644217	C	C	28644217	3	2	177	1	0	0	0	0	1	0	0	0	16296	1377	48	4	17	4	TMIGD1	17	28644217	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	9875031	28644217	52550993	237	33511											
KRT38	8687	broad.mit.edu	37	chr17	39594463	39594463	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccaggtcggcccggatctCagacagctgctcctccacgt	6	8	10	17	3	1	1	1	0	1	1	6	2	4	2	4	3	2	2	4	3	0	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:39594463C>T	uc002hwq.1	-	6	1546	c.1123G>A	c.(1123-1125)GAG>AAG	p.E375K		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	375	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				GCCCGGATCTCAGACAGCTGC	0.612													25	40					0	0	0	0	T	39594463	T	T	39594463	3	4	177	1	0	0	0	0	1	0	0	0	8514	835	29	2	255	2	KRT38	17	39594463	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	10950246	39594463	41600747	238	33512											
JUP	3728	broad.mit.edu	37	chr17	39680030	39680030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcagacaaattgttgtagtGatcttcctgtccctcgagca	9	12	10	10	1	1	2	0	1	1	1	4	3	3	2	2	1	1	4	2	1	2	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:39680030G>A	uc010wfs.1	-	9	1665	c.1657C>T	c.(1657-1659)CAC>TAC	p.H553Y	KRT15_uc002hxb.1_5'Flank|uc002hxc.1_5'Flank|KRT19_uc002hxd.3_Missense_Mutation_p.H390Y	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	Error:Variant_position_missing_in_P14923_after_alignment					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		TTGTTGTAGTGATCTTCCTGT	0.582													16	45					0	0	0	0	A	39680030	A	A	39680030	3	1	177	1	0	0	0	0	1	0	0	0	8011	1290	45	2		2	JUP	17	39680030	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	85567	39680030	41515180	239	33513											
EFTUD2	9343	broad.mit.edu	37	chr17	42934459	42934459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttacttcttattaggcgtttCagcaaagcacttgagggagg	10	13	11	7	1	2	1	1	1	1	0	2	2	2	2	0	3	3	3	0	3	4	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:42934459C>T	uc002ihn.2	-	20	2290	c.2029G>A	c.(2029-2031)GAA>AAA	p.E677K	EFTUD2_uc010wje.1_Missense_Mutation_p.E642K|EFTUD2_uc010wjf.1_Missense_Mutation_p.E667K	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	677						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				TTAGGCGTTTCAGCAAAGCAC	0.507													33	46					0	0	0	0	T	42934459	T	T	42934459	3	4	177	1	0	0	0	0	1	0	0	0	4983	835	29	2	925	2	EFTUD2	17	42934459	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	3254429	42934459	38260751	240	33514											
FAM117A	81558	broad.mit.edu	37	chr17	47797228	47797228	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggctgagtcgcaagacagggGaccctgaggggaagctggga	10	4	19	8	1	0	3	0	2	0	1	1	6	0	6	1	6	1	3	1	6	2	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:47797228G>A	uc002ipk.2	-	5	671	c.602C>T	c.(601-603)TCC>TTC	p.S201F	FAM117A_uc010wlz.1_5'UTR	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	201										ovary(1)	1						CAAGACAGGGGACCCTGAGGG	0.587													18	27					0	0	0	0	A	47797228	A	A	47797228	3	1	177	1	0	0	0	0	1	0	0	0	5437	1174	41	2	775	2	FAM117A	17	47797228	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	4862769	47797228	33397982	241	33515											
KIF19	124602	broad.mit.edu	37	chr17	72349698	72349698	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacagcagtgagaacctgtcGgagatccccttgtcccacaa	11	7	10	13	1	0	2	0	1	0	2	3	5	2	2	4	1	2	1	4	1	2	1	rs146555239	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:72349698G>A	uc002jkm.3	+	17	2424	c.2286G>A	c.(2284-2286)TCG>TCA	p.S762S		NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	762					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						AGAACCTGTCGGAGATCCCCT	0.592													13	27					0	0	0	0	A	72349698	A	A	72349698	2	1	177	1	0	0	0	0	0	0	0	1	8321	1103	39	1		1	KIF19	17	72349698	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	24552470	72349698	8845512	242	33516											
RNF213	57674	broad.mit.edu	37	chr17	78320969	78320969	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacgaaacggtgtgtaagcGccaggacaaggaattcttcg	12	8	12	9	4	1	0	0	0	1	0	2	3	1	2	1	3	3	1	1	3	5	4	rs76918558		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:78320969G>A	uc002jyh.1	+	4	3276	c.3053G>A	c.(3052-3054)CGC>CAC	p.R1018H		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTGTGTAAGCGCCAGGACAAG	0.532													6	17					0	0	0	0	A	78320969	A	A	78320969	3	1	177	1	0	0	0	0	1	0	0	0	13542	1087	38	1	9263	1	RNF213	17	78320969	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	5971271	78320969	2874241	243	33517											
LAMA3	3909	broad.mit.edu	37	chr18	21402267	21402267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtcaagtggctccttgtttCgtgttattctgagatacgtt	7	17	10	7	2	2	1	1	1	1	1	4	2	3	1	1	1	1	4	1	1	3	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:21402267C>T	uc002kuq.2	+	20	2442	c.2356C>T	c.(2356-2358)CGT>TGT	p.R786C	LAMA3_uc002kur.2_Missense_Mutation_p.R786C	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	786					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCCTTGTTTCGTGTTATTCT	0.383													33	59					0	0	0	0	T	21402267	T	T	21402267	3	4	177	1	0	0	0	0	1	0	0	0	8647	884	31	1	2434	1	LAMA3	18	21402267	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08		21402267	56674981	244	33518											
ASXL3	80816	broad.mit.edu	37	chr18	31325316	31325316	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagagagtagctaggactgTaggagaacacactcaagtta	17	7	11	6	0	1	2	1	0	0	2	1	5	1	3	0	2	2	4	0	2	7	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:31325316T>C	uc010dmg.1	+	12	5559	c.5504T>C	c.(5503-5505)GTA>GCA	p.V1835A	ASXL3_uc002kxq.2_Missense_Mutation_p.V1542A	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1835					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GCTAGGACTGTAGGAGAACAC	0.478													8	272					0	0	0	0	C	31325316	C	C	31325316	3	2	177	1	0	0	0	0	1	0	0	0	1070	1638	57	5	5550	5	ASXL3	18	31325316	Missense_Mutation	SNP	T	TCGA-CV-5442-01A-01D-1512-08	9923049	31325316	46751932	245	33519											
CXXC1	30827	broad.mit.edu	37	chr18	47812521	47812521	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctggatcagggacaggcctCttgcgccctccaccctcatc	6	9	9	17	1	4	0	2	0	2	0	6	2	5	2	4	3	1	0	4	3	0	1	rs149686544	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:47812521C>T	uc002leq.3	-	4	1063	c.330G>A	c.(328-330)AAG>AAA	p.K110K	CXXC1_uc002lep.3_5'UTR|CXXC1_uc002ler.3_Silent_p.K110K|CXXC1_uc010doy.2_Silent_p.K110K|CXXC1_uc002les.2_Silent_p.K110K	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	110					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GGACAGGCCTCTTGCGCCCTC	0.647													57	87					0	0	0	0	T	47812521	T	T	47812521	2	4	177	1	0	0	0	0	0	0	0	1	4114	912	32	2		2	CXXC1	18	47812521	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	16487205	47812521	30264727	246	33520											
MRO	83876	broad.mit.edu	37	chr18	48331680	48331680	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agtccatacaccagcaggtcGaggacaattttcttatactt	12	12	7	10	1	1	0	0	0	1	0	3	2	2	1	2	2	3	1	2	2	4	6			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:48331680G>C	uc002lew.3	-	5	567	c.273C>G	c.(271-273)CTC>CTG	p.L91L	MRO_uc010xdn.1_Silent_p.L91L|MRO_uc010dpa.2_Silent_p.L105L|MRO_uc010dpb.2_Silent_p.L105L|MRO_uc010dpc.2_Silent_p.L91L|MRO_uc002lex.3_Silent_p.L91L	NM_031939	NP_114145	Q9BYG7	MSTRO_HUMAN	maestro isoform a	91						nucleolus	binding				0		Colorectal(6;0.0596)		Colorectal(21;0.082)		CCAGCAGGTCGAGGACAATTT	0.463													39	54					0	0	0	0	C	48331680	C	C	48331680	2	2	177	1	0	0	0	0	0	0	0	1	9825	1045	37	3		3	MRO	18	48331680	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	519159	48331680	29745568	247	33521											
CDH20	28316	broad.mit.edu	37	chr18	59221574	59221574	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttcgacatcgcggccatgtgGaacccccgggaggcgcaggc	7	5	15	14	5	0	0	0	0	0	0	2	3	0	2	3	5	1	1	3	5	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:59221574G>C	uc010dps.1	+	11	2064	c.2052G>C	c.(2050-2052)TGG>TGC	p.W684C	CDH20_uc002lif.2_Missense_Mutation_p.W678C	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	684	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				CGGCCATGTGGAACCCCCGGG	0.682													38	63					0	0	0	0	C	59221574	C	C	59221574	3	2	177	1	0	0	0	0	1	0	0	0	3121	1183	41	2	2094	2	CDH20	18	59221574	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	10889894	59221574	18855674	248	33522											
ZNF407	55628	broad.mit.edu	37	chr18	72346054	72346054	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcactgtgagtttagtgctCactcctctgcttctctagag	6	15	9	11	0	3	2	1	1	2	1	5	2	4	2	1	0	3	4	1	0	2	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:72346054C>G	uc002llw.2	+	1	3136	c.3079C>G	c.(3079-3081)CAC>GAC	p.H1027D	ZNF407_uc010xfc.1_Missense_Mutation_p.H1027D|ZNF407_uc010dqu.1_Missense_Mutation_p.H1027D|ZNF407_uc002llu.2_Missense_Mutation_p.H1026D	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1027	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GTTTAGTGCTCACTCCTCTGC	0.488													59	92					0	0	0	0	G	72346054	G	G	72346054	3	3	177	1	0	0	0	0	1	0	0	0	17954	826	29	2	3081	2	ZNF407	18	72346054	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	13124480	72346054	5731194	249	33523											
SF3A2	8175	broad.mit.edu	37	chr19	2247868	2247868	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccacccccgctgatgaacGgtctgccccctcggccaccg	5	6	9	21	4	1	2	0	2	1	0	3	2	2	2	7	2	2	1	7	2	1	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:2247868G>A	uc002lvg.2	+	9	840	c.718G>A	c.(718-720)GGT>AGT	p.G240S	AMH_uc002lvh.2_5'Flank|hsa-mir-4321|MI0015852_5'Flank	NM_007165	NP_009096	Q15428	SF3A2_HUMAN	splicing factor 3a, subunit 2	240	Pro-rich.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex	nucleic acid binding|zinc ion binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGATGAACGGTCTGCCCCC	0.706													10	40					0	0	0	0	A	2247868	A	A	2247868	3	1	177	1	0	0	0	0	1	0	0	0	14212	1116	39	1	748	1	SF3A2	19	2247868	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08		2247868	56881115	250	33524											
VAV1	7409	broad.mit.edu	37	chr19	6828659	6828659	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcagtgcgtgaacgaggtCaagcgagacaacgagacact	13	5	13	10	4	2	3	2	1	0	2	2	6	2	3	0	1	4	1	0	1	3	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:6828659C>G	uc002mfu.1	+	12	1216	c.1119C>G	c.(1117-1119)GTC>GTG	p.V373V	VAV1_uc010xjh.1_Silent_p.V341V|VAV1_uc010dva.1_Silent_p.V373V|VAV1_uc002mfv.1_Silent_p.V318V	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	373	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						TGAACGAGGTCAAGCGAGACA	0.637													35	306					0	0	0	0	G	6828659	G	G	6828659	2	3	177	1	0	0	0	0	0	0	0	1	17199	813	29	2		2	VAV1	19	6828659	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	4580791	6828659	52300324	251	33525											
TIMM44	10469	broad.mit.edu	37	chr19	7998423	7998423	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccactgctggtaccacttgGagtccttgtgcagcacgacc	7	10	10	14	1	0	0	0	0	0	0	2	2	2	1	4	2	4	4	4	2	1	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:7998423G>A	uc002miz.2	-	7	718	c.716C>T	c.(715-717)TCC>TTC	p.S239F	TIMM44_uc002mja.2_5'UTR|TIMM44_uc010dvx.1_RNA	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	239					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						GTACCACTTGGAGTCCTTGTG	0.647													134	373					0	0	0	0	A	7998423	A	A	7998423	3	1	177	1	0	0	0	0	1	0	0	0	15978	1174	41	2	670	2	TIMM44	19	7998423	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	1169764	7998423	51130560	252	33526											
MYO1F	4542	broad.mit.edu	37	chr19	8606807	8606807	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactgctcactggtctgcatCagctctatgaggtcggagaa	9	10	11	11	1	4	2	2	1	2	1	5	3	4	2	0	3	3	3	0	3	2	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:8606807C>G	uc002mkg.2	-	15	1707	c.1593G>C	c.(1591-1593)CTG>CTC	p.L531L		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	531	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						TGGTCTGCATCAGCTCTATGA	0.622													27	78					0	0	0	0	G	8606807	G	G	8606807	2	3	177	1	0	0	0	0	0	0	0	1	10126	813	29	2		2	MYO1F	19	8606807	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	608384	8606807	50522176	253	33527											
MYO1F	4542	broad.mit.edu	37	chr19	8616660	8616660	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcttctgtcgtccgtgccGtccacctggtaggtgtccga	3	12	12	14	5	1	0	0	0	1	0	6	1	4	0	5	2	1	2	5	2	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:8616660G>A	uc002mkg.2	-	8	849	c.735C>T	c.(733-735)GAC>GAT	p.D245D	MYO1F_uc002mkh.2_Silent_p.D245D|MYO1F_uc010xkf.1_3'UTR	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	245	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						CGTCCGTGCCGTCCACCTGGT	0.607													49	118					0	0	0	0	A	8616660	A	A	8616660	2	1	177	1	0	0	0	0	0	0	0	1	10126	1136	40	1		1	MYO1F	19	8616660	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	9853	8616660	50512323	254	33528											
OR1M1	125963	broad.mit.edu	37	chr19	9204176	9204176	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaagatgctggtgagccttCaaaccgggagcaaggccatc	11	7	12	11	1	1	2	1	1	0	1	2	3	1	3	3	3	4	2	3	3	3	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:9204176C>T	uc010xkj.1	+	1	256	c.256C>T	c.(256-258)CAA>TAA	p.Q86*		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						GGTGAGCCTTCAAACCGGGAG	0.537													34	214					0	0	0	0	T	9204176	T	T	9204176	4	4	177	1	0	0	0	0	0	1	0	0	11022	827	29	2	258	2	OR1M1	19	9204176	Nonsense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	587516	9204176	49924807	255	33529											
ACP5	54	broad.mit.edu	37	chr19	11687634	11687634	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactttgcgaagggagcggtCagagaatacgtcctcaaagg	12	7	13	9	3	2	1	2	0	0	1	3	4	3	2	1	3	3	0	1	3	4	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:11687634C>G	uc002msg.3	-	3	432	c.286G>C	c.(286-288)GAC>CAC	p.D96H	ACP5_uc002msh.3_Missense_Mutation_p.D96H|ACP5_uc002msi.3_Missense_Mutation_p.D96H|ACP5_uc002msj.3_Missense_Mutation_p.D96H|ACP5_uc010dye.1_3'UTR	NM_001611	NP_001602	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	96					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			central_nervous_system(1)	1						AGGGAGCGGTCAGAGAATACG	0.547													36	108					0	0	0	0	G	11687634	G	G	11687634	3	3	177	1	0	0	0	0	1	0	0	0	164	826	29	2	703	2	ACP5	19	11687634	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2483458	11687634	47441349	256	33530											
CC2D1A	54862	broad.mit.edu	37	chr19	14040932	14040932	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcagctgcagttctacacgGaggctgcccggcgcctgggc	5	6	16	14	3	1	0	0	0	1	0	1	1	1	1	2	5	4	5	2	5	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:14040932G>A	uc002mxo.2	+	27	3051	c.2752G>A	c.(2752-2754)GAG>AAG	p.E918K	CC2D1A_uc002mxp.2_Missense_Mutation_p.E917K|CC2D1A_uc010dzh.2_Missense_Mutation_p.E487K	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	918					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GTTCTACACGGAGGCTGCCCG	0.687													8	21					0	0	0	0	A	14040932	A	A	14040932	3	1	177	1	0	0	0	0	1	0	0	0	2738	1175	41	2	2858	2	CC2D1A	19	14040932	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	2353298	14040932	45088051	257	33531											
JAK3	3718	broad.mit.edu	37	chr19	17945733	17945733	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaccgtggcgccgaagccCcacttgtcagcttccaagct	8	7	10	16	3	1	1	1	0	0	1	2	2	2	1	5	1	3	2	5	1	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:17945733C>G	uc002nhn.3	-	16	2227	c.2127G>C	c.(2125-2127)TGG>TGC	p.W709C	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Missense_Mutation_p.W709C	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	709	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CGCCGAAGCCCCACTTGTCAG	0.617		2	Mis		acute megakaryocytic leukemia|								51	118					0	0	0	0	G	17945733	G	G	17945733	3	3	177	1	0	0	0	0	1	0	0	0	7978	624	22	4	1283	4	JAK3	19	17945733	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	3904801	17945733	41183250	258	33532											
MAST3	23031	broad.mit.edu	37	chr19	18252811	18252811	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggactatggccgccggctGagtgctgacatccggtaagt	7	9	15	10	3	0	2	0	2	0	0	1	3	1	3	3	4	1	3	3	4	2	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:18252811G>A	uc002nhz.3	+	20	2238	c.2238G>A	c.(2236-2238)CTG>CTA	p.L746L		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	746							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						GCCGCCGGCTGAGTGCTGACA	0.597													4	16					0	0	0	0	A	18252811	A	A	18252811	2	1	177	1	0	0	0	0	0	0	0	1	9379	1277	45	2		2	MAST3	19	18252811	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	307078	18252811	40876172	259	33533											
GMIP	51291	broad.mit.edu	37	chr19	19740868	19740868	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcgagagtagccgggctgtCtcctgggtaatctcaaaatg	9	11	12	9	2	2	1	1	0	2	1	5	2	2	1	2	2	1	3	2	2	4	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:19740868C>T	uc002nnd.2	-	21	2934	c.2817G>A	c.(2815-2817)GAG>GAA	p.E939E	LPAR2_uc002nnb.3_5'Flank|LPAR2_uc002nna.3_5'Flank|LPAR2_uc002nnc.3_5'Flank|GMIP_uc010xrb.1_Silent_p.E913E|GMIP_uc010xrc.1_Silent_p.E910E	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	939					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						GCCGGGCTGTCTCCTGGGTAA	0.682													6	14					0	0	0	0	T	19740868	T	T	19740868	2	4	177	1	0	0	0	0	0	0	0	1	6528	912	32	2		2	GMIP	19	19740868	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	1488057	19740868	39388115	260	33534											
CCDC123	84902	broad.mit.edu	37	chr19	33370171	33370171	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctgggggcaaccagagctCtggggttgtcctgcacgcct	5	8	16	12	1	1	1	0	0	1	1	2	1	2	1	3	5	3	5	3	5	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:33370171C>T	uc002nty.2	-	19	2338	c.2249G>A	c.(2248-2250)AGA>AAA	p.R750K	CCDC123_uc002ntx.2_Missense_Mutation_p.R503K|CCDC123_uc010edg.2_RNA	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	750						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					AACCAGAGCTCTGGGGTTGTC	0.562													71	168					0	0	0	0	T	33370171	T	T	33370171	3	4	177	1	0	0	0	0	1	0	0	0	2771	913	32	2	106	2	CCDC123	19	33370171	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	13629303	33370171	25758812	261	33535											
ZNF573	126231	broad.mit.edu	37	chr19	38230601	38230601	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccagtatgaactctctgatGaattctaagatgtccacctt	11	13	7	10	0	2	4	0	3	2	1	4	4	3	4	3	0	1	1	3	0	4	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:38230601G>A	uc002ohe.2	-	4	812	c.790C>T	c.(790-792)CAT>TAT	p.H264Y	ZNF573_uc010efs.2_Missense_Mutation_p.H177Y|ZNF573_uc002ohd.2_Missense_Mutation_p.H262Y|ZNF573_uc002ohf.2_Missense_Mutation_p.H206Y|ZNF573_uc002ohg.2_Missense_Mutation_p.H176Y	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	244	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			ACTCTCTGATGAATTCTAAGA	0.428													68	165					0	0	0	0	A	38230601	A	A	38230601	3	1	177	1	0	0	0	0	1	0	0	0	18072	1290	45	2	1211	2	ZNF573	19	38230601	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	4860430	38230601	20898382	262	33536											
RYR1	6261	broad.mit.edu	37	chr19	38976258	38976258	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acatcctggagctgtcggagCgcctggacctgcagcgcttc	6	8	13	14	3	0	0	0	0	0	0	3	3	1	3	3	3	4	3	3	3	0	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:38976258C>T	uc002oit.2	+	34	5093	c.4963C>T	c.(4963-4965)CGC>TGC	p.R1655C	RYR1_uc002oiu.2_Missense_Mutation_p.R1655C	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1655	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCTGTCGGAGCGCCTGGACCT	0.602													22	74					0	0	0	0	T	38976258	T	T	38976258	3	4	177	1	0	0	0	0	1	0	0	0	13833	768	27	1	5097	1	RYR1	19	38976258	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	745657	38976258	20152725	263	33537											
CAPN12	147968	broad.mit.edu	37	chr19	39230743	39230743	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagggcatggcgcagggcaGagaacagccccatgctgttt	9	6	14	12	1	0	1	0	0	0	1	0	2	0	1	3	3	3	5	3	3	1	1	rs148710823	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:39230743G>C	uc002ojd.1	-	5	986	c.677C>G	c.(676-678)TCT>TGT	p.S226C		NM_144691	NP_653292	Q6ZSI9	CAN12_HUMAN	calpain 12	226	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GCGCAGGGCAGAGAACAGCCC	0.627													8	37					0	0	0	0	C	39230743	C	C	39230743	3	2	177	1	0	0	0	0	1	0	0	0	2637	942	33	2	1550	2	CAPN12	19	39230743	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	254485	39230743	19898240	264	33538											
GRIK5	2901	broad.mit.edu	37	chr19	42510807	42510807	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtggccccacctggaagaagGtcatggtggagccggcgtgg	7	6	18	10	2	1	1	1	0	0	1	1	3	1	3	4	7	1	0	4	7	2	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:42510807G>T	uc002osj.1	-	15	2062	c.2027C>A	c.(2026-2028)ACC>AAC	p.T676N	GRIK5_uc002osi.1_Missense_Mutation_p.T248N	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	676	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CTGGAAGAAGGTCATGGTGGA	0.622													7	28					2.74318e-10	2.81214e-10	1	0	T	42510807	T	T	42510807	3	4	177	1	0	0	0	0	1	0	0	0	6816	1261	44	4	935	4	GRIK5	19	42510807	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3280064	42510807	16618176	265	33539											
POU2F2	5452	broad.mit.edu	37	chr19	42599758	42599758	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgatgctggtcctcttcttgCgtctccggccgggcaggccg	2	10	14	15	5	3	0	0	0	3	0	5	1	4	0	4	4	2	2	4	4	0	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:42599758C>T	uc002osp.2	-	10	960	c.893G>A	c.(892-894)CGC>CAC	p.R298H	POU2F2_uc002osn.2_Missense_Mutation_p.R282H|POU2F2_uc002oso.2_Missense_Mutation_p.R71H|POU2F2_uc002osq.2_Missense_Mutation_p.R282H|POU2F2_uc002osr.1_Missense_Mutation_p.R298H	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	298	Homeobox.				humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				CCTCTTCTTGCGTCTCCGGCC	0.647													8	29					0	0	0	0	T	42599758	T	T	42599758	3	4	177	1	0	0	0	0	1	0	0	0	12327	768	27	1	566	1	POU2F2	19	42599758	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	88951	42599758	16529225	266	33540											
SYMPK	8189	broad.mit.edu	37	chr19	46319745	46319745	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgcagggccctcacctcctCcaagggccccgcaggcgcct	5	5	11	20	2	1	0	1	0	0	0	3	0	3	0	7	3	1	2	7	3	1	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:46319745C>G	uc002pdn.2	-	25	3594	c.3349G>C	c.(3349-3351)GAG>CAG	p.E1117Q	RSPH6A_uc002pdm.2_5'Flank	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	1117					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CTCACCTCCTCCAAGGGCCCC	0.657													9	28					0	0	0	0	G	46319745	G	G	46319745	3	3	177	1	0	0	0	0	1	0	0	0	15505	864	30	2	487	2	SYMPK	19	46319745	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	3719987	46319745	12809238	267	33541											
RPL28	6158	broad.mit.edu	37	chr19	55899356	55899356	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaacaagaatgctcgcgcCacgctcagcagcatcagaca	14	5	8	14	3	3	2	3	0	0	2	4	2	3	2	1	0	4	4	1	0	3	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:55899356C>T	uc002qkv.2	+	4	306	c.264C>T	c.(262-264)GCC>GCT	p.A88A	RPL28_uc010yga.1_Silent_p.A88A|RPL28_uc010ygb.1_Silent_p.A88A|RPL28_uc002qkw.1_3'UTR	NM_000991	NP_000982	P46779	RL28_HUMAN	ribosomal protein L28 isoform 2	88					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0	Breast(117;0.191)	Renal(1328;0.245)	LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		ATGCTCGCGCCACGCTCAGCA	0.622													52	139					0	0	0	0	T	55899356	T	T	55899356	2	4	177	1	0	0	0	0	0	0	0	1	13642	581	21	4		4	RPL28	19	55899356	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	9579611	55899356	3229627	268	33542											
ZNF835	90485	broad.mit.edu	37	chr19	57175433	57175433	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgtgcacgaggcggtgctgGaggaggtgggagcggttgct	5	8	22	6	3	0	0	0	0	0	0	0	4	0	3	0	7	4	4	0	7	0	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:57175433G>A	uc010ygo.1	-	2	1200	c.1200C>T	c.(1198-1200)CTC>CTT	p.L400L	ZNF835_uc010ygn.1_Silent_p.L378L	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GGCGGTGCTGGAGGAGGTGGG	0.667													8	36					0	0	0	0	A	57175433	A	A	57175433	2	1	177	1	0	0	0	0	0	0	0	1	18253	1161	41	2		2	ZNF835	19	57175433	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	1276077	57175433	1953550	269	33543											
ZNF549	256051	broad.mit.edu	37	chr19	58048682	58048682	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccttccatcccaaatgctCattcttgtgagatgtgtatc	8	15	7	11	0	2	1	1	1	1	1	6	2	5	1	3	0	1	2	3	0	2	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:58048682C>T	uc002qpb.1	+	4	559	c.310C>T	c.(310-312)CAT>TAT	p.H104Y	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Missense_Mutation_p.H91Y	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	104	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCAAATGCTCATTCTTGTGA	0.512													49	138					0	0	0	0	T	58048682	T	T	58048682	3	4	177	1	0	0	0	0	1	0	0	0	18048	826	29	2	281	2	ZNF549	19	58048682	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	873249	58048682	1080301	270	33544											
ZNF211	10520	broad.mit.edu	37	chr19	58153100	58153100	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccagcctcattcaccacCggagacttcacactggagaa	11	7	8	15	1	3	2	3	0	0	2	4	4	4	2	4	2	1	1	4	2	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:58153100C>T	uc002qpq.2	+	3	1426	c.1246C>T	c.(1246-1248)CGG>TGG	p.R416W	ZNF211_uc010yhb.1_Missense_Mutation_p.R420W|ZNF211_uc002qpp.2_Missense_Mutation_p.R429W|ZNF211_uc002qpr.2_Missense_Mutation_p.R480W|ZNF211_uc002qps.2_Missense_Mutation_p.R481W|ZNF211_uc002qpt.2_Missense_Mutation_p.R428W|ZNF211_uc010yhc.1_Missense_Mutation_p.R428W|ZNF211_uc010yhd.1_Missense_Mutation_p.R355W|ZNF211_uc010yhe.1_Missense_Mutation_p.R407W	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	416	C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CATTCACCACCGGAGACTTCA	0.478													39	77					0	0	0	0	T	58153100	T	T	58153100	3	4	177	1	0	0	0	0	1	0	0	0	17834	643	23	1	1299	1	ZNF211	19	58153100	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	104418	58153100	975883	271	33545											
ZSCAN4	201516	broad.mit.edu	37	chr19	58189590	58189590	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaaaactactcgagtaaatGaaaatattactaatcaaggc	19	9	6	7	2	1	1	1	1	0	0	2	3	1	1	0	1	3	1	0	1	11	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:58189590G>T	uc002qpu.2	+	5	1316	c.619G>T	c.(619-621)GAA>TAA	p.E207*		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	207					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCGAGTAAATGAAAATATTAC	0.403													32	70					4.2108e-06	4.30463e-06	1	0	T	58189590	T	T	58189590	4	4	177	1	0	0	0	0	0	1	0	0	18304	1291	45	2	629	2	ZSCAN4	19	58189590	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	36490	58189590	939393	272	33546											
PLCB4	5332	broad.mit.edu	37	chr20	9416276	9416276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagagagcagaccaaatgaGagctatgggcattgaaactg	17	6	12	6	0	0	4	0	2	0	3	0	6	0	4	1	1	3	3	1	1	4	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:9416276G>A	uc002wnf.2	+	27	2694	c.2558G>A	c.(2557-2559)AGA>AAA	p.R853K	PLCB4_uc010gbw.1_Missense_Mutation_p.R853K|PLCB4_uc010gbx.2_Missense_Mutation_p.R865K|PLCB4_uc002wne.2_Missense_Mutation_p.R853K|PLCB4_uc002wnh.2_Missense_Mutation_p.R700K	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	853					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						GACCAAATGAGAGCTATGGGC	0.368													28	79					0	0	0	0	A	9416276	A	A	9416276	3	1	177	1	0	0	0	0	1	0	0	0	12085	942	33	2	2696	2	PLCB4	20	9416276	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08		9416276	53609244	273	33547											
CHD6	84181	broad.mit.edu	37	chr20	40065914	40065914	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atactgcacatttgactcacCgtttgtttctggaggccatc	8	14	8	11	1	2	1	1	1	1	0	3	2	2	2	2	2	2	3	2	2	1	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:40065914C>T	uc002xka.1	-	27	4246	c.4068G>A	c.(4066-4068)ACG>ACA	p.T1356T	CHD6_uc002xkb.1_Silent_p.T122T	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1356					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TTTGACTCACCGTTTGTTTCT	0.373													25	117					0	0	0	0	T	40065914	T	T	40065914	2	4	177	1	0	0	0	0	0	0	0	1	3344	666	23	1		1	CHD6	20	40065914	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	30649638	40065914	22959606	274	33548											
HNF4A	3172	broad.mit.edu	37	chr20	43030051	43030051	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgtcgacatggacatggcCgactacagtgctgcactgga	9	8	12	12	3	0	0	0	0	0	0	2	4	0	2	1	3	3	2	1	3	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:43030051C>T	uc002xma.2	+	1	128	c.39C>T	c.(37-39)GCC>GCT	p.A13A	HNF4A_uc010zwo.1_Intron|HNF4A_uc002xlt.2_Intron|HNF4A_uc002xlu.2_Intron|HNF4A_uc002xlv.2_Intron|uc002xlw.1_Intron|HNF4A_uc002xly.2_Silent_p.A13A|HNF4A_uc002xlz.2_Silent_p.A13A|HNF4A_uc010ggq.2_5'UTR	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	13					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TGGACATGGCCGACTACAGTG	0.637													31	92					0	0	0	0	T	43030051	T	T	43030051	2	4	177	1	0	0	0	0	0	0	0	1	7292	639	23	1		1	HNF4A	20	43030051	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	2964137	43030051	19995469	275	33549											
NCOA3	8202	broad.mit.edu	37	chr20	46264311	46264311	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggcatgcaatcaccatcttCctaccagaacaacaactatg	15	8	5	13	0	2	1	1	0	1	1	3	1	3	1	3	1	5	2	3	1	6	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:46264311C>T	uc002xtk.2	+	11	1563	c.1358C>T	c.(1357-1359)TCC>TTC	p.S453F	NCOA3_uc010ght.1_Missense_Mutation_p.S463F|NCOA3_uc002xtl.2_Missense_Mutation_p.S453F|NCOA3_uc002xtm.2_Missense_Mutation_p.S453F|NCOA3_uc002xtn.2_Missense_Mutation_p.S453F|NCOA3_uc010zyc.1_Missense_Mutation_p.S248F	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	453					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TCACCATCTTCCTACCAGAAC	0.522													26	82					0	0	0	0	T	46264311	T	T	46264311	3	4	177	1	0	0	0	0	1	0	0	0	10284	855	30	2	1422	2	NCOA3	20	46264311	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	3234260	46264311	16761209	276	33550											
ADNP	23394	broad.mit.edu	37	chr20	49508078	49508078	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccactcaatctgggggttaGataagcgctcatcattctca	10	11	9	11	1	5	1	4	0	2	1	6	1	5	1	1	2	1	2	1	2	3	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:49508078G>C	uc002xvt.1	-	5	3518	c.3173C>G	c.(3172-3174)TCT>TGT	p.S1058C	ADNP_uc002xvu.1_Missense_Mutation_p.S1058C	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	1058						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						CTGGGGGTTAGATAAGCGCTC	0.458													56	194					0	0	0	0	C	49508078	C	C	49508078	3	2	177	1	0	0	0	0	1	0	0	0	323	942	33	2	139	2	ADNP	20	49508078	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3243767	49508078	13517442	277	33551											
CTCFL	140690	broad.mit.edu	37	chr20	56073693	56073693	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgtggtttctctgcaggcGacaggaaacatctctcctgg	7	11	12	11	1	2	0	0	0	2	0	5	2	3	1	1	4	2	3	1	4	1	1	rs141206026	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:56073693G>A	uc010gix.1	-	10	2567	c.1905C>T	c.(1903-1905)GTC>GTT	p.V635V	CTCFL_uc010giw.1_Silent_p.V635V|CTCFL_uc002xym.2_Silent_p.V635V|CTCFL_uc010giz.1_Silent_p.V223V|CTCFL_uc010giy.1_Silent_p.V305V|CTCFL_uc010gja.1_Silent_p.V585V|CTCFL_uc010gjb.1_Silent_p.V635V|CTCFL_uc010gjc.1_Silent_p.V635V|CTCFL_uc010gjd.1_Silent_p.V635V|CTCFL_uc010giu.2_RNA|CTCFL_uc010giv.2_Intron	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	635					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CTCTGCAGGCGACAGGAAACA	0.502													37	101					0	0	0	0	A	56073693	A	A	56073693	2	1	177	1	0	0	0	0	0	0	0	1	4018	1045	37	1		1	CTCFL	20	56073693	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	6565615	56073693	6951827	278	33552											
LIPI	149998	broad.mit.edu	37	chr21	15525004	15525004	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atactgagaacaaaataataGgctacaaaataaaaatatag	24	8	5	4	0	0	1	0	1	0	1	0	2	0	1	0	1	3	1	0	1	14	7			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr21:15525004G>A	uc002yjm.2	-	8	1081	c.1071C>T	c.(1069-1071)ACC>ACT	p.T357T		NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	336					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		CAAAATAATAGGCTACAAAAT	0.209													9	22					0	0	0	0	A	15525004	A	A	15525004	2	1	177	1	0	0	0	0	0	0	0	1	8867	1014	35	4		4	LIPI	21	15525004	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08		15525004	32604891	279	33553											
SON	6651	broad.mit.edu	37	chr21	34931547	34931547	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttaaagaaatgtaaacaGatcgcacagagtaaagaaga	20	8	8	5	1	0	5	0	0	0	5	1	5	0	5	0	0	1	3	0	0	8	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr21:34931547G>A	uc002yse.1	+	5	6382	c.6333G>A	c.(6331-6333)CAG>CAA	p.Q2111Q	SON_uc002ysc.2_Silent_p.Q2111Q|SON_uc002ysd.2_Silent_p.Q1102Q|SON_uc002ysf.1_Silent_p.Q139Q|SON_uc002ysg.2_Silent_p.Q1102Q	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	2111					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						AATGTAAACAGATCGCACAGA	0.303													23	61					0	0	0	0	A	34931547	A	A	34931547	2	1	177	1	0	0	0	0	0	0	0	1	14990	933	33	2		2	SON	21	34931547	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	19406543	34931547	13198348	280	33554											
PCNT	5116	broad.mit.edu	37	chr21	47836709	47836709	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgctggcactgcagtgggccGagtctccgccggctgacgac	5	6	15	15	5	1	1	0	1	1	0	2	3	1	1	3	3	1	4	3	3	0	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr21:47836709G>A	uc002zji.3	+	30	6984	c.6877G>A	c.(6877-6879)GAG>AAG	p.E2293K	PCNT_uc002zjj.2_Missense_Mutation_p.E2175K	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2293					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding	p.E2293K(1)		ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCAGTGGGCCGAGTCTCCGCC	0.692													19	19					0	0	0	0	A	47836709	A	A	47836709	3	1	177	1	0	0	0	0	1	0	0	0	11644	1059	37	1	6995	1	PCNT	21	47836709	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	12905162	47836709	293186	281	33555											
MAPK1	5594	broad.mit.edu	37	chr22	22127164	22127164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggaacatgagctcttacctCgtcactcgggtcgtaatact	10	11	9	11	3	2	1	1	1	1	0	5	2	2	2	1	2	4	2	1	2	4	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:22127164C>T	uc002zvn.2	-	7	1204	c.964G>A	c.(964-966)GAG>AAG	p.E322K	MAPK1_uc002zvo.2_Missense_Mutation_p.E322K|MAPK1_uc010gtk.1_Missense_Mutation_p.E278K	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	322					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	GCTCTTACCTCGTCACTCGGG	0.478													20	37					0	0	0	0	T	22127164	T	T	22127164	3	4	177	1	0	0	0	0	1	0	0	0	9324	893	31	1	126	1	MAPK1	22	22127164	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08		22127164	29177402	282	33556											
ADRBK2	157	broad.mit.edu	37	chr22	26083563	26083563	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctctgagaaggagatgcggTtttatgccactgaaatcatt	11	13	10	7	1	2	3	1	2	1	2	3	5	2	3	1	2	2	1	1	2	3	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:26083563T>A	uc003abx.3	+	11	1033	c.886T>A	c.(886-888)TTT>ATT	p.F296I	ADRBK2_uc010gux.2_Missense_Mutation_p.F296I|ADRBK2_uc003abw.2_Missense_Mutation_p.F183I|ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	296	Protein kinase.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	GGAGATGCGGTTTTATGCCAC	0.428													22	39					0	0	0	0	A	26083563	A	A	26083563	3	1	177	1	0	0	0	0	1	0	0	0	344	1725	60	5	928	5	ADRBK2	22	26083563	Missense_Mutation	SNP	T	TCGA-CV-5442-01A-01D-1512-08	3956399	26083563	25221003	283	33557											
TBC1D10A	83874	broad.mit.edu	37	chr22	30691791	30691791	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggtgcaggtcacgctcaatCacgtccagccacttggggtc	7	8	12	14	3	3	0	3	0	0	0	5	0	4	0	2	4	2	2	2	4	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:30691791C>T	uc011akt.1	-	4	483	c.459G>A	c.(457-459)GTG>GTA	p.V153V	GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_RNA|GATSL3_uc003ahh.2_RNA|GATSL3_uc010gvq.2_RNA|GATSL3_uc003ahi.2_Silent_p.V11V|TBC1D10A_uc003ahj.3_Silent_p.V65V|TBC1D10A_uc010gvu.2_Silent_p.V160V|TBC1D10A_uc003ahk.3_Silent_p.V153V	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	153	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CACGCTCAATCACGTCCAGCC	0.627													10	28					0	0	0	0	T	30691791	T	T	30691791	2	4	177	1	0	0	0	0	0	0	0	1	15664	813	29	2		2	TBC1D10A	22	30691791	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	4608228	30691791	20612775	284	33558											
RFPL3	10738	broad.mit.edu	37	chr22	32756289	32756289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaacttcctcctcatttctGacgacctcaggagcgtccga	9	10	7	15	3	3	1	2	1	1	0	6	4	6	2	4	1	2	0	4	1	1	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:32756289G>A	uc003amj.2	+	2	629	c.424G>A	c.(424-426)GAC>AAC	p.D142N	RFPL3_uc010gwn.2_Missense_Mutation_p.D113N|RFPL3S_uc003amk.2_RNA|RFPL3S_uc003aml.2_RNA	NM_001098535	NP_001092005	O75679	RFPL3_HUMAN	ret finger protein-like 3 isoform 1	142	B30.2/SPRY.						zinc ion binding			ovary(1)	1						CCTCATTTCTGACGACCTCAG	0.532													45	92					0	0	0	0	A	32756289	A	A	32756289	3	1	177	1	0	0	0	0	1	0	0	0	13320	1290	45	2	430	2	RFPL3	22	32756289	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	2064498	32756289	18548277	285	33559											
TNRC6B	23112	broad.mit.edu	37	chr22	40662468	40662468	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caatcaaggatggtcttctgGaaagaatggttggggggagg	11	9	17	4	0	3	1	1	0	2	1	3	4	3	4	0	8	0	1	0	8	4	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:40662468G>C	uc011aor.1	+	5	2445	c.2234G>C	c.(2233-2235)GGA>GCA	p.G745A	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Missense_Mutation_p.G745A|TNRC6B_uc003ayo.2_Missense_Mutation_p.G549A	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	745					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						TGGTCTTCTGGAAAGAATGGT	0.517													11	27					0	0	0	0	C	40662468	C	C	40662468	3	2	177	1	0	0	0	0	1	0	0	0	16407	1174	41	2	2373	2	TNRC6B	22	40662468	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	7906179	40662468	10642098	286	33560											
NAGA	4668	broad.mit.edu	37	chr22	42461763	42461763	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atgtcagggtcattccagtgCccagggccggccactggctg	6	8	14	13	1	2	0	2	0	0	0	3	0	3	0	4	4	1	1	4	4	0	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:42461763C>T	uc003bbx.2	-	7	875	c.738G>A	c.(736-738)GGG>GGA	p.G246G	NAGA_uc003bby.2_Silent_p.G246G|NAGA_uc003bbw.3_Silent_p.G246G	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	246					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						CATTCCAGTGCCCAGGGCCGG	0.587													14	48					0	0	0	0	T	42461763	T	T	42461763	2	4	177	1	0	0	0	0	0	0	0	1	10194	726	26	4		4	NAGA	22	42461763	Silent	SNP	C	TCGA-CV-5442-01A-01D-1512-08	1799295	42461763	8842803	287	33561											
MCAT	27349	broad.mit.edu	37	chr22	43529294	43529294	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcttgtggatgtgccCgggatgcctgtatctatgcg	6	11	14	10	2	1	0	0	0	1	0	1	2	1	2	2	2	5	3	2	2	2	3	rs144085201		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:43529294C>T	uc003bdl.1	-	4	977	c.928G>A	c.(928-930)GGG>AGG	p.G310R	MCAT_uc003bdm.1_3'UTR	NM_173467	NP_775738	Q8IVS2	FABD_HUMAN	mitochondrial malonyltransferase isoform a	310					fatty acid biosynthetic process	mitochondrion	[acyl-carrier-protein] S-malonyltransferase activity|binding			ovary(1)	1		Ovarian(80;0.0694)				TGGATGTGCCCGGGATGCCTG	0.567													16	150					0	0	0	0	T	43529294	T	T	43529294	3	4	177	1	0	0	0	0	1	0	0	0	9425	652	23	1	248	1	MCAT	22	43529294	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	1067531	43529294	7775272	288	33562											
GRAMD4	23151	broad.mit.edu	37	chr22	47071407	47071407	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaatctgggtcctcaaagagGaacaaagtcatcaagctagt	16	8	9	8	0	4	1	3	0	1	1	5	2	5	2	1	2	2	1	1	2	6	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:47071407G>A	uc003bhx.2	+	16	1560	c.1521G>A	c.(1519-1521)AGG>AGA	p.R507R	GRAMD4_uc010had.2_Silent_p.R446R|GRAMD4_uc003bhy.2_Silent_p.R30R	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	507	GRAM.				apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		CCTCAAAGAGGAACAAAGTCA	0.552													76	109					0	0	0	0	A	47071407	A	A	47071407	2	1	177	1	0	0	0	0	0	0	0	1	6791	1165	41	2		2	GRAMD4	22	47071407	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3542113	47071407	4233159	289	33563											
GYG2	8908	broad.mit.edu	37	chrX	2773149	2773149	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccagccttctctccacaCgcataaactcctgctacagc	9	10	4	18	1	1	0	0	0	1	0	5	0	4	0	4	0	5	2	4	0	3	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:2773149C>T	uc004cqs.1	+	6	815	c.533C>T	c.(532-534)ACG>ATG	p.T178M	GYG2_uc004cqt.1_Missense_Mutation_p.T147M|GYG2_uc004cqu.1_Missense_Mutation_p.T147M|GYG2_uc004cqv.1_Translation_Start_Site|GYG2_uc004cqw.1_Missense_Mutation_p.T138M|GYG2_uc004cqx.1_Missense_Mutation_p.T147M|GYG2_uc010ndc.1_Translation_Start_Site	NM_003918	NP_003909	O15488	GLYG2_HUMAN	glycogenin 2 isoform b	178					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|soluble fraction	glycogenin glucosyltransferase activity			ovary(1)|kidney(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTCTCCACACGCATAAACTC	0.502													54	160					0	0	0	0	T	2773149	T	T	2773149	3	4	177	1	0	0	0	0	1	0	0	0	6945	536	19	1	551	1	GYG2	23	2773149	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08		2773149	152497411	290	33564											
ARSF	416	broad.mit.edu	37	chrX	3002413	3002413	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgctggccggacccctctcGtaacacggaattagcctttg	7	10	10	14	3	1	0	0	0	1	0	2	2	1	2	4	3	3	2	4	3	3	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:3002413G>A	uc004cre.1	+	6	757	c.536G>A	c.(535-537)CGT>CAT	p.R179H	ARSF_uc004crf.1_Missense_Mutation_p.R179H	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	179						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GACCCCTCTCGTAACACGGAA	0.537													52	113					0	0	0	0	A	3002413	A	A	3002413	3	1	177	1	0	0	0	0	1	0	0	0	993	1145	40	1	554	1	ARSF	23	3002413	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	229264	3002413	152268147	291	33565											
STS	412	broad.mit.edu	37	chrX	7268021	7268021	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacacgtgtgcttctgtttcGggagttatgtcacccatcac	7	13	9	12	2	3	0	2	0	1	0	4	1	3	1	1	1	1	3	1	1	1	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:7268021G>A	uc004cry.3	+	10	1716	c.1471G>A	c.(1471-1473)GGG>AGG	p.G491R		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	491	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CTTCTGTTTCGGGAGTTATGT	0.507									Ichthyosis				55	142					0	0	0	0	A	7268021	A	A	7268021	3	1	177	1	0	0	0	0	1	0	0	0	15398	1116	39	1	1509	1	STS	23	7268021	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	4265608	7268021	148002539	292	33566											
HCCS	3052	broad.mit.edu	37	chrX	11135450	11135450	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattgtctactgtcagagaaGagtcatccattccgagagca	12	10	9	10	1	3	3	2	0	1	3	5	5	5	3	2	0	2	1	2	0	2	3	rs144634482		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:11135450G>C	uc004cuk.2	+	4	582	c.316G>C	c.(316-318)GAG>CAG	p.E106Q	HCCS_uc004cuj.2_Missense_Mutation_p.E106Q|HCCS_uc004cul.1_Missense_Mutation_p.E106Q	NM_005333	NP_005324	P53701	CCHL_HUMAN	holocytochrome c synthase	106					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding				0						TGTCAGAGAAGAGTCATCCAT	0.393													72	172					0	0	0	0	C	11135450	C	C	11135450	3	2	177	1	0	0	0	0	1	0	0	0	7029	943	33	2	326	2	HCCS	23	11135450	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	3867429	11135450	144135110	293	33567											
BMX	660	broad.mit.edu	37	chrX	15555263	15555263	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttgccttgttaggaatctGggaactgaaaagagaagaga	14	10	12	5	0	2	3	0	1	2	2	2	7	2	5	1	2	2	1	1	2	6	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:15555263G>T	uc004cww.2	+	14	1417	c.1229G>T	c.(1228-1230)TGG>TTG	p.W410L	BMX_uc004cwx.3_Missense_Mutation_p.W410L|BMX_uc004cwy.3_Missense_Mutation_p.W410L	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	410					cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					TTAGGAATCTGGGAACTGAAA	0.483													91	271					9.24773e-40	9.8948e-40	1	0	T	15555263	T	T	15555263	3	4	177	1	0	0	0	0	1	0	0	0	1476	1357	47	4	1279	4	BMX	23	15555263	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	4419813	15555263	139715297	294	33568											
SH3KBP1	30011	broad.mit.edu	37	chrX	19702076	19702076	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgcagttgccactgtcccGttggcaccttcagacttggt	5	12	11	13	1	1	1	1	0	0	1	2	1	2	1	3	2	2	5	3	2	0	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:19702076G>A	uc004czm.2	-	6	907	c.591C>T	c.(589-591)AAC>AAT	p.N197N	SH3KBP1_uc004czl.2_Silent_p.N160N	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	197					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						CCACTGTCCCGTTGGCACCTT	0.507													65	167					0	0	0	0	A	19702076	A	A	19702076	2	1	177	1	0	0	0	0	0	0	0	1	14320	1136	40	1		1	SH3KBP1	23	19702076	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	4146813	19702076	135568484	295	33569											
OTC	5009	broad.mit.edu	37	chrX	38262913	38262913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcttaccctcagctggatcGgggatgggaacaatatcctg	9	10	12	10	1	2	0	1	0	1	0	4	3	3	3	2	4	3	1	2	4	4	2	rs67294956		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:38262913G>A	uc004def.3	+	6	797	c.583G>A	c.(583-585)GGG>AGG	p.G195R		NM_000531	NP_000522	P00480	OTC_HUMAN	ornithine carbamoyltransferase precursor	195			G -> R (in OTCD; no activity).		arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			ovary(1)|breast(1)	2					L-Citrulline(DB00155)|L-Ornithine(DB00129)	CAGCTGGATCGGGGATGGGAA	0.478													43	91					0	0	0	0	A	38262913	A	A	38262913	3	1	177	1	0	0	0	0	1	0	0	0	11355	1116	39	1	605	1	OTC	23	38262913	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	18560837	38262913	117007647	296	33570											
PPP1R3F	89801	broad.mit.edu	37	chrX	49142813	49142813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccctggctgaggagatcaCgctgcactatgcccggctgg	6	7	14	14	3	1	2	1	1	0	1	1	3	1	2	2	4	2	4	2	4	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:49142813C>T	uc004dnh.1	+	4	1677	c.1661C>T	c.(1660-1662)ACG>ATG	p.T554M	PPP1R3F_uc011mnd.1_Missense_Mutation_p.T225M|PPP1R3F_uc004dni.2_Missense_Mutation_p.T208M|PPP1R3F_uc004dnj.1_Missense_Mutation_p.T208M	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	554	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					GAGGAGATCACGCTGCACTAT	0.647													16	39					0	0	0	0	T	49142813	T	T	49142813	3	4	177	1	0	0	0	0	1	0	0	0	12435	536	19	1	1675	1	PPP1R3F	23	49142813	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	10879900	49142813	106127747	297	33571											
KDM5C	8242	broad.mit.edu	37	chrX	53243984	53243984	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcacacagcaggagcttgtCatcctcatcccctcgagaac	11	8	7	15	1	3	1	3	0	0	1	6	3	5	2	3	1	3	2	3	1	1	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:53243984C>T	uc004drz.2	-	8	1542	c.1009G>A	c.(1009-1011)GAC>AAC	p.D337N	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Missense_Mutation_p.D270N|KDM5C_uc004dsa.2_Missense_Mutation_p.D336N	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	337	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						AGGAGCTTGTCATCCTCATCC	0.537			N|F|S		clear cell renal carcinoma								22	38					0	0	0	0	T	53243984	T	T	53243984	3	4	177	1	0	0	0	0	1	0	0	0	8174	826	29	2	3847	2	KDM5C	23	53243984	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	4101171	53243984	102026576	298	33572											
HUWE1	10075	broad.mit.edu	37	chrX	53573555	53573555	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagtgggatgtcaacaccTgagaaaaagaagacagaagg	19	4	13	5	0	1	5	1	1	0	5	1	7	1	6	1	2	1	0	1	2	6	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:53573555T>A	uc004dsp.2	-	70	11161	c.10759_splice	c.e70-1	p.V3587_splice	HUWE1_uc004dsn.2_Splice_Site_p.V2395_splice|HUWE1_uc004dsq.1_5'Flank	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1						base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TGTCAACACCTGAGAAAAAGA	0.502													24	27					0	0	0	0	A	53573555	A	A	53573555	5	1	177	1	0	0	0	0	0	0	1	0	7500	1594	55	5	2427	5	HUWE1	23	53573555	Splice_Site	SNP	T	TCGA-CV-5442-01A-01D-1512-08	329571	53573555	101697005	299	33573											
IGBP1	3476	broad.mit.edu	37	chrX	69385733	69385733	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagaacaagaagaaaaggagGaagaggatgatgaacaaaca	24	2	12	3	0	0	6	0	2	0	4	0	9	0	9	0	3	3	0	0	3	9	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:69385733G>A	uc004dxv.2	+	6	1421	c.922G>A	c.(922-924)GAA>AAA	p.E308K	IGBP1_uc004dxw.2_Missense_Mutation_p.E308K	NM_001551	NP_001542	P78318	IGBP1_HUMAN	immunoglobulin binding protein 1	308					B cell activation|negative regulation of caspase activity|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|regulation of microtubule-based movement|response to interleukin-1|response to tumor necrosis factor|signal transduction	cytoplasm	protein phosphatase type 2A regulator activity			kidney(1)|pancreas(1)	2						AGAAAAGGAGGAAGAGGATGA	0.468													17	41					0	0	0	0	A	69385733	A	A	69385733	3	1	177	1	0	0	0	0	1	0	0	0	7606	1175	41	2	944	2	IGBP1	23	69385733	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	15812178	69385733	85884827	300	33574											
KIF4A	24137	broad.mit.edu	37	chrX	69595998	69595998	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcgtcaaatgaaagaagatGctgagaagtttagacagtgg	15	9	13	4	1	1	5	1	2	0	4	1	6	1	5	0	1	2	2	0	1	5	2			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:69595998G>A	uc004dyg.2	+	18	2099	c.1972G>A	c.(1972-1974)GCT>ACT	p.A658T	KIF4A_uc010nkw.2_Missense_Mutation_p.A658T|KIF4A_uc004dyf.1_Missense_Mutation_p.A658T	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	658	Potential.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						GAAAGAAGATGCTGAGAAGTT	0.338													21	58					0	0	0	0	A	69595998	A	A	69595998	3	1	177	1	0	0	0	0	1	0	0	0	8342	1319	46	4	2038	4	KIF4A	23	69595998	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	210265	69595998	85674562	301	33575											
CXCR3	2833	broad.mit.edu	37	chrX	70836869	70836870	+	Frame_Shift_Ins	INS	-	AGGT	AGGT																															gggtggcatgaactatgttcINSaggtagcggtcaaagctgat																										TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:70836869_70836870insAGGT	uc004eaf.2	-	2	520_521	c.452_453insACCT	c.(451-453)CTGfs	p.L151fs	BCYRN1_uc011mpt.1_Intron|CXCR3_uc011mpx.1_Frame_Shift_Ins_p.L198fs	NM_001504	NP_001495	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3 isoform A	151	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			ovary(2)|central_nervous_system(1)	3	Renal(35;0.156)					GAACTATGTTCAGGTAGCGGTC	0.52													---	---	---								AGGT	70836870	AGGT	AGGT	70836869	7	5	177	1	0	1	1	0	0	0	0	0	4109	813	29	0	657	0	CXCR3	23	70836869	Frame_Shift_Ins	INS	-	TCGA-CV-5442-01A-01D-1512-08	1240871	70836869	84433691	302	33576											
RPS6KA6	27330	broad.mit.edu	37	chrX	83361414	83361414	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtagttgcatgtatgcatcGcttgcaaacagagtaggagc	11	10	13	7	1	0	1	0	0	0	1	1	2	0	2	0	2	5	8	0	2	4	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:83361414G>A	uc004eej.1	-	15	1401	c.1324C>T	c.(1324-1326)CGA>TGA	p.R442*	RPS6KA6_uc011mqt.1_Nonsense_Mutation_p.R442*|RPS6KA6_uc011mqu.1_Nonsense_Mutation_p.R339*	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	442	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TGTATGCATCGCTTGCAAACA	0.348													10	34					0	0	0	0	A	83361414	A	A	83361414	4	1	177	1	0	0	0	0	0	1	0	0	13720	1095	38	1	945	1	RPS6KA6	23	83361414	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	12524545	83361414	71909146	303	33577											
RHOXF1	158800	broad.mit.edu	37	chrX	119249462	119249462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaacttcgtgcgccgagttCgtggctgcatgttctcgggc	4	12	14	11	5	1	1	0	1	1	0	4	2	1	1	1	2	3	4	1	2	1	3			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:119249462C>T	uc004esk.1	-	1	386	c.311G>A	c.(310-312)CGA>CAA	p.R104Q	uc004esi.1_Intron	NM_139282	NP_644811	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	104	Homeobox.				gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCGCCGAGTTCGTGGCTGCAT	0.652													31	101					0	0	0	0	T	119249462	T	T	119249462	3	4	177	1	0	0	0	0	1	0	0	0	13412	884	31	1	255	1	RHOXF1	23	119249462	Missense_Mutation	SNP	C	TCGA-CV-5442-01A-01D-1512-08	35888048	119249462	36021098	304	33578											
FRMD7	90167	broad.mit.edu	37	chrX	131212241	131212241	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctaaattctgacccaaaagGaaaacgaatagttttcatgt	16	12	6	7	1	3	1	1	1	2	0	3	3	3	2	1	1	1	1	1	1	8	5			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:131212241G>A	uc004ewn.2	-	12	1982	c.1804C>T	c.(1804-1806)CCT>TCT	p.P602S	FRMD7_uc011muy.1_Missense_Mutation_p.P587S	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	602					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GACCCAAAAGGAAAACGAATA	0.433													56	170					0	0	0	0	A	131212241	A	A	131212241	3	1	177	1	0	0	0	0	1	0	0	0	6089	1174	41	2	344	2	FRMD7	23	131212241	Missense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	11962779	131212241	24058319	305	33579											
ATP11C	286410	broad.mit.edu	37	chrX	138840005	138840005	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaactggtacaaaaactGtggcaaaatgaaacaaaggt	20	6	10	5	0	0	2	0	1	0	1	0	3	0	2	0	3	4	2	0	3	9	1			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:138840005G>A	uc004faz.2	-	23	2770	c.2671C>T	c.(2671-2673)CAG>TAG	p.Q891*	ATP11C_uc004fax.2_Nonsense_Mutation_p.Q99*|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Nonsense_Mutation_p.Q891*	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	891	Helical; (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TACAAAAACTGTGGCAAAATG	0.289													13	33					0	0	0	0	A	138840005	A	A	138840005	4	1	177	1	0	0	0	0	0	1	0	0	1123	1386	48	4	822	4	ATP11C	23	138840005	Nonsense_Mutation	SNP	G	TCGA-CV-5442-01A-01D-1512-08	7627764	138840005	16430555	306	33580											
SLITRK4	139065	broad.mit.edu	37	chrX	142718807	142718807	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaccttctcacagttgacatAgagcacattctcaactgaca	14	10	5	12	0	2	3	2	2	2	1	4	3	2	3	1	0	3	2	1	0	3	4			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:142718807A>G	uc004fbx.2	-	2	494	c.118T>C	c.(118-120)TAT>CAT	p.Y40H	SLITRK4_uc004fby.2_Missense_Mutation_p.Y40H	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	40	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CAGTTGACATAGAGCACATTC	0.373													5	163					0	0	0	0	G	142718807	G	G	142718807	3	3	177	1	0	0	0	0	1	0	0	0	14809	420	15	5	2399	5	SLITRK4	23	142718807	Missense_Mutation	SNP	A	TCGA-CV-5442-01A-01D-1512-08	3878802	142718807	12551753	307	33581											
SLITRK2	84631	broad.mit.edu	37	chrX	144904855	144904855	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccgaaagccagccggccGcccaaaatgagaaatcgtcc	12	4	10	15	4	0	1	0	1	0	1	3	3	2	1	6	1	2	1	6	1	4	0			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:144904855G>A	uc004fcd.2	+	5	1902	c.912G>A	c.(910-912)CCG>CCA	p.P304P	SLITRK2_uc010nsp.2_Silent_p.P304P|SLITRK2_uc010nso.2_Silent_p.P304P|SLITRK2_uc011mwq.1_Silent_p.P304P|SLITRK2_uc011mwr.1_Silent_p.P304P|SLITRK2_uc011mws.1_Silent_p.P304P|SLITRK2_uc004fcg.2_Silent_p.P304P|SLITRK2_uc011mwt.1_Silent_p.P304P	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	304	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGCCGGCCGCCCAAAATGA	0.557													59	133					0	0	0	0	A	144904855	A	A	144904855	2	1	177	1	0	0	0	0	0	0	0	1	14807	1074	38	1		1	SLITRK2	23	144904855	Silent	SNP	G	TCGA-CV-5442-01A-01D-1512-08	2186048	144904855	10365705	308	33582											
TIE1	7075	broad.mit.edu	37	chr1	43777409	43777409	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgccagcttgtggtctccccGctggtctcgttctctgggga	2	12	13	14	3	3	0	0	0	3	0	6	1	3	1	3	4	1	3	3	4	0	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr1:43777409G>A	uc001ciu.2	+	10	1480	c.1401G>A	c.(1399-1401)CCG>CCA	p.P467P	TIE1_uc010okd.1_Silent_p.P467P|TIE1_uc010oke.1_Silent_p.P422P|TIE1_uc009vwq.2_Silent_p.P423P|TIE1_uc010okf.1_Silent_p.P112P|TIE1_uc010okg.1_Silent_p.P112P	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	467	Extracellular (Potential).|Fibronectin type-III 1.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGGTCTCCCCGCTGGTCTCGT	0.647													23	60					0	0	0	0	A	43777409	A	A	43777409	2	1	178	1	0	0	0	0	0	0	0	1	15959	1074	38	1		1	TIE1	1	43777409	Silent	SNP	G	TCGA-CV-5443-01A-01D-1512-08		43777409	205473212	1	33583											
MPL	4352	broad.mit.edu	37	chr1	43804269	43804269	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catgccccactttggaacccGatacgtgtgccagtttccag	8	10	9	14	2	0	0	0	0	0	0	1	2	1	1	5	1	4	1	5	1	2	3			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr1:43804269G>A	uc001ciw.2	+	3	314	c.269G>A	c.(268-270)CGA>CAA	p.R90Q	MPL_uc001civ.2_Missense_Mutation_p.R90Q|MPL_uc009vwr.2_Missense_Mutation_p.R83Q	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	90	Extracellular (Potential).				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTTGGAACCCGATACGTGTGC	0.572			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						23	84					0	0	0	0	A	43804269	A	A	43804269	3	1	178	1	0	0	0	0	1	0	0	0	9783	1058	37	1	279	1	MPL	1	43804269	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	26860	43804269	205446352	2	33584											
PAQR6	79957	broad.mit.edu	37	chr1	156214599	156214599	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcctttcaggcaggtgggagGcgaagaggaagccagtgagc	10	5	18	8	1	1	2	1	1	0	1	1	5	1	4	2	5	2	1	2	5	2	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr1:156214599G>T	uc001fnu.1	-	7	783	c.713C>A	c.(712-714)GCC>GAC	p.A238D	PAQR6_uc010phf.1_Intron|PAQR6_uc001fny.1_Missense_Mutation_p.P16T|PAQR6_uc001fnv.1_Missense_Mutation_p.A214D|PAQR6_uc010phg.1_Missense_Mutation_p.A235D|PAQR6_uc001fnx.1_Missense_Mutation_p.A132D|PAQR6_uc001fnw.1_Missense_Mutation_p.A132D|PAQR6_uc001fnz.1_Missense_Mutation_p.A132D|PAQR6_uc010phh.1_Missense_Mutation_p.A238D|PAQR6_uc001foa.1_Missense_Mutation_p.A132D|PAQR6_uc001fob.1_RNA	NM_198406	NP_940798	Q6TCH4	PAQR6_HUMAN	progestin and adipoQ receptor family member VI	238	Helical; (Potential).					integral to membrane	receptor activity				0	Hepatocellular(266;0.158)					CAGGTGGGAGGCGAAGAGGAA	0.672													15	42					0.00400662	0.00414168	1	0	T	156214599	T	T	156214599	3	4	178	1	0	0	0	0	1	0	0	0	11493	1203	42	4	668	4	PAQR6	1	156214599	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	112410330	156214599	93036022	3	33585											
OR2M3	127062	broad.mit.edu	37	chr1	248366532	248366532	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcatctacctggacacccagCtccacacccccatgtacctc	9	8	4	20	0	2	0	1	0	1	0	4	1	3	1	6	1	3	2	6	1	2	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr1:248366532C>A	uc010pzg.1	+	1	163	c.163C>A	c.(163-165)CTC>ATC	p.L55I		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGACACCCAGCTCCACACCCC	0.557													114	271					1.54771e-57	1.82551e-57	1	0	A	248366532	A	A	248366532	3	1	178	1	0	0	0	0	1	0	0	0	11065	797	28	4	165	4	OR2M3	1	248366532	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	92151933	248366532	884089	4	33586											
C2orf16	84226	broad.mit.edu	37	chr2	27804538	27804538	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatcgcagtccctctcagaGgagccatcgtggtccctctg	7	9	10	15	2	2	1	1	0	2	1	7	2	4	2	3	2	1	1	3	2	0	0			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr2:27804538G>A	uc002rkz.3	+	1	5150	c.5099G>A	c.(5098-5100)AGG>AAG	p.R1700K	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1700	9.|27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CCCTCTCAGAGGAGCCATCGT	0.587													8	237					0	0	0	0	A	27804538	A	A	27804538	3	1	178	1	0	0	0	0	1	0	0	0	2167	1000	35	4	5101	4	C2orf16	2	27804538	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08		27804538	215394835	5	33587											
RMND5A	64795	broad.mit.edu	37	chr2	86947840	86947840	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctggagaaggtgctgcacaAgttctcaggctacgggcagc	9	7	15	10	1	1	1	1	0	1	1	2	2	1	1	0	4	4	6	0	4	3	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr2:86947840A>T	uc010ytm.1	+	1	427	c.50A>T	c.(49-51)AAG>ATG	p.K17M	RMND5A_uc002srs.3_Translation_Start_Site|VPS24_uc010ytl.1_Intron|RMND5A_uc002srr.2_Missense_Mutation_p.K17M	NM_022780	NP_073617	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog	17										ovary(1)|skin(1)	2						GTGCTGCACAAGTTCTCAGGC	0.687													4	1					0	0	0	0	T	86947840	T	T	86947840	3	4	178	1	0	0	0	0	1	0	0	0	13462	72	3	5	52	5	RMND5A	2	86947840	Missense_Mutation	SNP	A	TCGA-CV-5443-01A-01D-1512-08	59143302	86947840	156251533	6	33588											
CNTNAP5	129684	broad.mit.edu	37	chr2	125175049	125175049	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaaacatgaatgctgacagCgtggtgcaccacaagctatt	13	8	11	9	1	0	2	0	2	0	0	0	3	0	3	1	2	5	3	1	2	4	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr2:125175049C>G	uc002tno.2	+	4	775	c.411C>G	c.(409-411)AGC>AGG	p.S137R	CNTNAP5_uc010flu.2_Missense_Mutation_p.S137R	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	137	F5/8 type C.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		ATGCTGACAGCGTGGTGCACC	0.488													11	25					0	0	0	0	G	125175049	G	G	125175049	3	3	178	1	0	0	0	0	1	0	0	0	3665	767	27	3	425	3	CNTNAP5	2	125175049	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	38227209	125175049	118024324	7	33589											
CNTNAP5	129684	broad.mit.edu	37	chr2	125204332	125204332	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctcccctcttcacaggtGacagcaaagcgcggctcagc	8	8	9	16	2	4	1	2	1	2	0	6	1	5	1	2	2	3	2	2	2	1	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr2:125204332G>T	uc002tno.2	+	6	1100	c.736G>T	c.(736-738)GAC>TAC	p.D246Y	CNTNAP5_uc010flu.2_Missense_Mutation_p.D246Y	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	246	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTTCACAGGTGACAGCAAAGC	0.567													15	53					1.67942e-08	1.81772e-08	1	0	T	125204332	T	T	125204332	3	4	178	1	0	0	0	0	1	0	0	0	3665	1290	45	2	758	2	CNTNAP5	2	125204332	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	29283	125204332	117995041	8	33590											
LRP1B	53353	broad.mit.edu	37	chr2	141598619	141598619	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctaatccagtataaattaCgtgacacccaatccactgct	14	10	5	12	1	0	1	0	1	0	0	2	1	2	1	3	0	3	3	3	0	6	4			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr2:141598619C>T	uc002tvj.1	-	30	5954	c.4982G>A	c.(4981-4983)CGT>CAT	p.R1661H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1661	Extracellular (Potential).|LDL-receptor class B 15.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTATAAATTACGTGACACCCA	0.373										TSP Lung(27;0.18)			24	80					0	0	0	0	T	141598619	T	T	141598619	3	4	178	1	0	0	0	0	1	0	0	0	9005	536	19	1	9065	1	LRP1B	2	141598619	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	16394287	141598619	101600754	9	33591											
TMEM198	130612	broad.mit.edu	37	chr2	220412472	220412472	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctgccctgctgggctcCgcaccctactaccagccagg	5	7	11	18	1	0	0	0	0	0	0	1	0	1	0	5	2	6	5	5	2	2	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr2:220412472C>T	uc002vme.2	+	4	996	c.411C>T	c.(409-411)TCC>TCT	p.S137S	TMEM198_uc002vmf.2_Silent_p.S137S	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	137	Leu-rich.					integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TGCTGGGCTCCGCACCCTACT	0.716													12	32					0	0	0	0	T	220412472	T	T	220412472	2	4	178	1	0	0	0	0	0	0	0	1	16185	639	23	1		1	TMEM198	2	220412472	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08	78813853	220412472	22786901	10	33592											
MORC1	27136	broad.mit.edu	37	chr3	108773723	108773723	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaattccaaccacgcctgcGccaagtctgagaaaatatat	15	8	6	12	2	1	1	0	1	1	1	2	2	2	1	4	0	2	0	4	0	7	3	rs7631480	byFrequency	TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr3:108773723G>A	uc003dxl.2	-	14	1269	c.1182C>T	c.(1180-1182)GGC>GGT	p.G394G	MORC1_uc011bhn.1_Silent_p.G394G	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	394					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding	p.G394G(1)		ovary(3)|skin(3)|breast(2)	8						CCACGCCTGCGCCAAGTCTGA	0.303													22	57					0	0	0	0	A	108773723	A	A	108773723	2	1	178	1	0	0	0	0	0	0	0	1	9754	1074	38	1		1	MORC1	3	108773723	Silent	SNP	G	TCGA-CV-5443-01A-01D-1512-08		108773723	89248707	11	33593											
XRN1	54464	broad.mit.edu	37	chr3	142103391	142103391	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aatagtttgataaacaaaagGaacaacttgttttgaccact	17	12	6	6	0	0	2	0	2	0	0	0	3	0	3	1	1	3	2	1	1	8	6			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr3:142103391G>T	uc003eus.2	-	21	2543	c.2476C>A	c.(2476-2478)CCT>ACT	p.P826T	XRN1_uc010huu.2_Missense_Mutation_p.P292T|XRN1_uc003eut.2_Missense_Mutation_p.P826T|XRN1_uc003euu.2_Missense_Mutation_p.P826T|XRN1_uc003euv.1_Missense_Mutation_p.P687T	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	826					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						TAAACAAAAGGAACAACTTGT	0.308													26	89					1.85244e-09	2.02886e-09	1	0	T	142103391	T	T	142103391	3	4	178	1	0	0	0	0	1	0	0	0	17527	1174	41	2	2732	2	XRN1	3	142103391	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	33329668	142103391	55919039	12	33594											
TBC1D1	23216	broad.mit.edu	37	chr4	38023338	38023338	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagctctgtgagaggatagaGggtgagtaggggaccctttc	10	9	16	6	0	1	3	0	2	1	2	2	6	1	5	1	4	1	2	1	4	3	3			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr4:38023338G>C	uc003gtb.2	+	6	1552	c.1209G>C	c.(1207-1209)GAG>GAC	p.E403D	TBC1D1_uc011byd.1_Missense_Mutation_p.E403D|TBC1D1_uc010ifd.2_Missense_Mutation_p.E150D|TBC1D1_uc011byf.1_Missense_Mutation_p.E274D	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	403	PID.					nucleus	Rab GTPase activator activity			ovary(1)	1						AGAGGATAGAGGGTGAGTAGG	0.552													3	20					0	0	0	0	C	38023338	C	C	38023338	3	2	178	1	0	0	0	0	1	0	0	0	15663	1014	35	4	1227	4	TBC1D1	4	38023338	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08		38023338	153130938	13	33595											
SMARCAD1	56916	broad.mit.edu	37	chr4	95155227	95155227	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagatgctaaacttcagaCtttgaaggaactttttccac	14	13	6	8	0	1	3	1	1	0	2	2	4	2	4	1	1	3	1	1	1	6	6			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr4:95155227C>T	uc003htc.3	+	4	746	c.491C>T	c.(490-492)ACT>ATT	p.T164I	SMARCAD1_uc003htb.3_Missense_Mutation_p.T164I|SMARCAD1_uc003htd.3_Missense_Mutation_p.T164I|SMARCAD1_uc010ila.2_Missense_Mutation_p.T27I	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	164	CUE 1.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		aaacttcagactttgaaggaa	0.144													19	29					0	0	0	0	T	95155227	T	T	95155227	3	4	178	1	0	0	0	0	1	0	0	0	14836	565	20	4	501	4	SMARCAD1	4	95155227	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	57131889	95155227	95999049	14	33596											
ADH4	127	broad.mit.edu	37	chr4	100062705	100062705	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaatacctggtttgacgttGgtcactcctggcccaatact	10	12	8	11	1	1	1	1	1	0	0	2	1	2	1	3	3	2	2	3	3	5	4			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr4:100062705G>T	uc003hun.2	-	3	325	c.249C>A	c.(247-249)ACC>ACA	p.T83T	uc003hum.1_Intron|ADH4_uc011ced.1_Silent_p.T102T	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	83					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	GTTTGACGTTGGTCACTCCTG	0.398													21	42					0.00395357	0.00413328	1	0	T	100062705	T	T	100062705	2	4	178	1	0	0	0	0	0	0	0	1	310	1335	47	4		4	ADH4	4	100062705	Silent	SNP	G	TCGA-CV-5443-01A-01D-1512-08	4907478	100062705	91091571	15	33597											
BRD9	65980	broad.mit.edu	37	chr5	878568	878568	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatactgaattattctgcatCgaaagcgcagtagtggcact	13	11	9	8	2	1	1	0	1	1	0	2	2	1	1	0	1	3	4	0	1	6	4			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr5:878568C>T	uc003jbq.2	-	11	1340	c.1173G>A	c.(1171-1173)TCG>TCA	p.S391S	BRD9_uc003jbl.2_Silent_p.S275S|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Silent_p.S338S|BRD9_uc003jbo.2_Silent_p.S295S|BRD9_uc003jbp.2_Silent_p.S52S|BRD9_uc011cmc.1_RNA	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	391							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			TATTCTGCATCGAAAGCGCAG	0.567													9	124					0	0	0	0	T	878568	T	T	878568	2	4	178	1	0	0	0	0	0	0	0	1	1512	871	31	1		1	BRD9	5	878568	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08		878568	180036692	16	33598											
ADAMTS12	81792	broad.mit.edu	37	chr5	33549375	33549375	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttacagctcatgctcaatggGggaggaatgccggccaggaa	11	7	14	9	1	2	0	2	0	0	0	2	3	2	3	2	5	4	2	2	5	4	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr5:33549375G>A	uc003jia.1	-	21	4402	c.4239C>T	c.(4237-4239)CCC>CCT	p.P1413P	ADAMTS12_uc010iuq.1_Silent_p.P1328P	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1413	TSP type-1 6.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGCTCAATGGGGGAGGAATGC	0.612										HNSCC(64;0.19)			24	59					0	0	0	0	A	33549375	A	A	33549375	2	1	178	1	0	0	0	0	0	0	0	1	257	1219	43	4		4	ADAMTS12	5	33549375	Silent	SNP	G	TCGA-CV-5443-01A-01D-1512-08	32670807	33549375	147365885	17	33599											
RAI14	26064	broad.mit.edu	37	chr5	34824125	34824125	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggatgcacaaaaagagaaCtctgtctctatcacagaaca	16	8	8	9	0	3	2	1	0	2	2	4	4	3	3	0	1	3	1	0	1	5	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr5:34824125C>T	uc003jir.2	+	15	2374	c.2178C>T	c.(2176-2178)AAC>AAT	p.N726N	RAI14_uc010iur.2_Silent_p.N697N|RAI14_uc011coj.1_Silent_p.N726N|RAI14_uc003jis.2_Silent_p.N729N|RAI14_uc003jit.2_Silent_p.N726N|RAI14_uc011cok.1_Silent_p.N718N	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	726	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					AAAAAGAGAACTCTGTCTCTA	0.408													25	33					0	0	0	0	T	34824125	T	T	34824125	2	4	178	1	0	0	0	0	0	0	0	1	13073	564	20	4		4	RAI14	5	34824125	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08	1274750	34824125	146091135	18	33600											
MCC	4163	broad.mit.edu	37	chr5	112632624	112632624	+	5'Flank	DEL	A	-	-																															tgttcaaccaaaagaaaagtAatctgttccaaaagtagagg																										TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr5:112632624delA	uc003kqj.3	-						MCC_uc003kqk.3_Intron|MCC_uc003kql.3_Intron|MCC_uc011cwb.1_5'Flank|MCC_uc010jcd.1_5'Flank	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2						negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		aaagaaaagtaatctgttcca	0													---	---	---								-	112632624	-	-	112632624	6	5	178	0	1	1	0	1	0	0	0	0	9426	377	13	0		0	MCC	5	112632624	5'Flank	DEL	A	TCGA-CV-5443-01A-01D-1512-08	77808499	112632624	68282636	19	33601											
GPRIN1	114787	broad.mit.edu	37	chr5	176024594	176024594	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctcggccttcggctccaCgcggccttcactgcccctgg	2	8	13	18	4	1	0	1	0	0	0	4	0	2	0	5	5	1	2	5	5	0	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr5:176024594C>T	uc003meo.1	-	2	2417	c.2242G>A	c.(2242-2244)GTG>ATG	p.V748M		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	748						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCGGCTCCACGCGGCCTTCA	0.687													7	19					0	0	0	0	T	176024594	T	T	176024594	3	4	178	1	0	0	0	0	1	0	0	0	6768	536	19	1	788	1	GPRIN1	5	176024594	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	63391970	176024594	4890666	20	33602											
CCHCR1	54535	broad.mit.edu	37	chr6	31112526	31112526	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtctgagagttgctccCgcagccgagtttccacttca	6	12	10	13	2	2	1	1	1	1	1	4	3	4	1	3	0	2	4	3	0	0	3	rs111409280		TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr6:31112526C>T	uc003nsr.3	-	15	1961	c.1838G>A	c.(1837-1839)CGG>CAG	p.R613Q	CCHCR1_uc011dne.1_Missense_Mutation_p.R613Q|CCHCR1_uc003nsq.3_Missense_Mutation_p.R666Q|CCHCR1_uc003nsp.3_Missense_Mutation_p.R702Q|CCHCR1_uc010jsk.1_Missense_Mutation_p.R645Q	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	613	Potential.				cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						GAGTTGCTCCCGCAGCCGAGT	0.597													53	106					0	0	0	0	T	31112526	T	T	31112526	3	4	178	1	0	0	0	0	1	0	0	0	2890	652	23	1	526	1	CCHCR1	6	31112526	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08		31112526	140002541	21	33603											
C4A	720	broad.mit.edu	37	chr6	31997106	31997106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acctcatggcaatggcccagGagactggaggtgaggggtga	10	6	17	8	0	1	3	1	2	0	1	1	5	1	4	2	7	0	1	2	7	1	0			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr6:31997106G>A	uc011dpd.1	+	28	3718	c.3667G>A	c.(3667-3669)GAG>AAG	p.E1223K	C4A_uc011dpe.1_Missense_Mutation_p.E1223K	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	1223					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						AATGGCCCAGGAGACTGGAGG	0.642													9	55					0	0	0	0	A	31997106	A	A	31997106	3	1	178	1	0	0	0	0	1	0	0	0	2257	1175	41	2		2	C4A	6	31997106	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	884580	31997106	139117961	22	33604											
PHIP	55023	broad.mit.edu	37	chr6	79697996	79697996	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttccaatgcagatcttgtaCgataattgtgttgatttgtc	9	17	8	7	1	1	2	0	1	1	1	3	3	2	2	1	0	2	3	1	0	3	7			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr6:79697996C>T	uc003pir.2	-	21	2616	c.2390G>A	c.(2389-2391)CGT>CAT	p.R797H	PHIP_uc011dyp.1_Missense_Mutation_p.R796H	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	797					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		AGATCTTGTACGATAATTGTG	0.338													5	101					0	0	0	0	T	79697996	T	T	79697996	3	4	178	1	0	0	0	0	1	0	0	0	11897	536	19	1	3155	1	PHIP	6	79697996	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	47700890	79697996	91417071	23	33605											
SLC22A16	85413	broad.mit.edu	37	chr6	110763501	110763509	+	In_Frame_Del	DEL	AAAACGAGT	-	-																															taagttaacagaattcaaggAaaacgagtagaatcccaaac																								rs149948718	by1000genomes	TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr6:110763501_110763509delAAAACGAGT	uc003puf.2	-	4	1188_1196	c.1121_1129delACTCGTTTT	c.(1120-1131)TACTCGTTTTCC>TCC	p.YSF374del	SLC22A16_uc003pue.2_In_Frame_Del_p.YSF355del	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	374_376	Helical; (Potential).				acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		GAATTCAAGGAAAACGAGTAGAATCCCAA	0.378													---	---	---								-	110763509	-	-	110763501	7	5	178	1	0	1	0	1	0	0	0	0	14512	246	9	0	624	0	SLC22A16	6	110763501	In_Frame_Del	DEL	AAAACGAGT	TCGA-CV-5443-01A-01D-1512-08	31065505	110763501	60351566	24	33606											
IFNGR1	3459	broad.mit.edu	37	chr6	137527279	137527279	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacattctactcaccatctcGgcatacagcaaattcttctg	11	12	4	14	1	5	0	1	0	4	0	6	0	5	0	1	1	3	2	1	1	3	5			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr6:137527279G>A	uc003qho.2	-	3	470	c.367C>T	c.(367-369)CGA>TGA	p.R123*	IFNGR1_uc011edm.1_Nonsense_Mutation_p.R95*|IFNGR1_uc011edn.1_Nonsense_Mutation_p.R113*	NM_000416	NP_000407	P15260	INGR1_HUMAN	interferon gamma receptor 1 precursor	123	Extracellular (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	TCACCATCTCGGCATACAGCA	0.348													7	118					0	0	0	0	A	137527279	A	A	137527279	4	1	178	1	0	0	0	0	0	1	0	0	7588	1124	39	1	1122	1	IFNGR1	6	137527279	Nonsense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	26763778	137527279	33587788	25	33607											
SYNE1	23345	broad.mit.edu	37	chr6	152763322	152763322	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccccttctccctgctgcGcctgcgcgatctgctgctgc	1	10	10	20	3	2	0	0	0	2	0	3	1	2	0	5	0	6	3	5	0	0	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr6:152763322G>A	uc010kiw.2	-	31	4498	c.3896C>T	c.(3895-3897)GCG>GTG	p.A1299V	SYNE1_uc003qot.3_Missense_Mutation_p.A1306V|SYNE1_uc003qou.3_Missense_Mutation_p.A1299V|SYNE1_uc010kjb.1_Missense_Mutation_p.A1282V|SYNE1_uc003qow.2_Missense_Mutation_p.A594V|SYNE1_uc003qox.1_Missense_Mutation_p.A815V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1299	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCCCTGCTGCGCCTGCGCGAT	0.567										HNSCC(10;0.0054)			22	91					0	0	0	0	A	152763322	A	A	152763322	3	1	178	1	0	0	0	0	1	0	0	0	15511	1087	38	1	23034	1	SYNE1	6	152763322	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	15236043	152763322	18351745	26	33608											
C7orf57	136288	broad.mit.edu	37	chr7	48081064	48081064	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggactcggagatactggatAaaagaaacagattcggaata	17	7	12	5	2	0	3	0	0	0	3	2	7	0	6	0	4	2	0	0	4	6	4			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr7:48081064A>G	uc003toh.3	+	3	401	c.189A>G	c.(187-189)ATA>ATG	p.I63M	C7orf57_uc003toi.3_Translation_Start_Site	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	63										ovary(1)	1						GATACTGGATAAAAGAAACAG	0.592													13	18					0	0	0	0	G	48081064	G	G	48081064	3	3	178	1	0	0	0	0	1	0	0	0	2415	352	13	5	195	5	C7orf57	7	48081064	Missense_Mutation	SNP	A	TCGA-CV-5443-01A-01D-1512-08		48081064	111057599	27	33609											
RELN	5649	broad.mit.edu	37	chr7	103214639	103214639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgttccacagccagttcCaacctgggcacctgttatct	9	11	8	13	0	1	0	0	0	1	0	3	0	3	0	5	1	2	4	5	1	3	3			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr7:103214639C>T	uc003vca.2	-	30	4571	c.4411G>A	c.(4411-4413)GGA>AGA	p.G1471R	RELN_uc010liz.2_Missense_Mutation_p.G1471R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1471					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGCCAGTTCCAACCTGGGCA	0.512													8	123					0	0	0	0	T	103214639	T	T	103214639	3	4	178	1	0	0	0	0	1	0	0	0	13285	603	21	4	6115	4	RELN	7	103214639	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	55133575	103214639	55924024	28	33610											
EPHB6	2051	broad.mit.edu	37	chr7	142563798	142563798	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcgcctgcctcgggagctgGggggtcgaggggacctgctc	3	6	20	12	3	0	0	0	0	0	0	3	3	0	2	3	7	3	2	3	7	0	0			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr7:142563798G>A	uc011kst.1	+	9	1973	c.1186G>A	c.(1186-1188)GGG>AGG	p.G396R	EPHB6_uc011ksu.1_Missense_Mutation_p.G396R|EPHB6_uc003wbs.2_Missense_Mutation_p.G104R|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Missense_Mutation_p.G104R|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	396	Extracellular (Potential).|Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					TCGGGAGCTGGGGGGTCGAGG	0.652													7	19					0	0	0	0	A	142563798	A	A	142563798	3	1	178	1	0	0	0	0	1	0	0	0	5202	1232	43	4	1204	4	EPHB6	7	142563798	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	39349159	142563798	16574865	29	33611											
HR	55806	broad.mit.edu	37	chr8	21973915	21973915	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagaggaagtgctgagtgacGctgactgtgctcaccaggcc	9	7	15	10	1	1	4	1	3	0	1	1	6	1	5	2	2	2	3	2	2	1	0			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr8:21973915G>A	uc003xas.2	-	18	4070	c.3405C>T	c.(3403-3405)AGC>AGT	p.S1135S	HR_uc003xat.2_Silent_p.S1080S	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	1135	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GCTGAGTGACGCTGACTGTGC	0.627													9	26					0	0	0	0	A	21973915	A	A	21973915	2	1	178	1	0	0	0	0	0	0	0	1	7386	1078	38	1		1	HR	8	21973915	Silent	SNP	G	TCGA-CV-5443-01A-01D-1512-08		21973915	124390107	30	33612											
KLF10	7071	broad.mit.edu	37	chr8	103664557	103664557	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagcttcaaaatcacttttCtctgcagttttgttccagga	10	15	6	10	0	3	0	2	0	1	0	5	1	4	1	1	1	2	4	1	1	2	6			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr8:103664557C>T	uc011lhk.1	-	2	259	c.105G>A	c.(103-105)GAG>GAA	p.E35E	KLF10_uc011lhj.1_Silent_p.E24E	NM_005655	NP_005646	Q13118	KLF10_HUMAN	Kruppel-like factor 10 isoform a	35					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			AATCACTTTTCTCTGCAGTTT	0.358													53	130					0	0	0	0	T	103664557	T	T	103664557	2	4	178	1	0	0	0	0	0	0	0	1	8377	912	32	2		2	KLF10	8	103664557	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08	81690642	103664557	42699465	31	33613											
GRIN1	2902	broad.mit.edu	37	chr9	140058119	140058119	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacttttgagaacatggcCggtgcgttctccttcatcca	7	14	8	12	2	2	1	1	1	1	1	4	2	3	1	3	2	3	1	3	2	2	5			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr9:140058119C>G	uc004clk.2	+	17	2772	c.2442C>G	c.(2440-2442)GCC>GCG	p.A814A	GRIN1_uc004cli.1_Silent_p.A489A|GRIN1_uc004clj.1_Silent_p.A811A|GRIN1_uc004cll.2_Silent_p.A814A|GRIN1_uc004clm.2_Silent_p.A814A|GRIN1_uc004cln.2_Silent_p.A832A|GRIN1_uc004clo.2_Silent_p.A832A	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	814	Helical; (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	AGAACATGGCCGGTGCGTTCT	0.597													13	40					0	0	0	0	G	140058119	G	G	140058119	2	3	178	1	0	0	0	0	0	0	0	1	6817	666	23	3		3	GRIN1	9	140058119	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08		140058119	1155312	32	33614											
PTCHD3	374308	broad.mit.edu	37	chr10	27702649	27702649	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcgccgctccgccttggcCgggctccccacaggggtgta	5	6	14	16	4	0	0	0	0	0	0	2	0	2	0	6	4	1	3	6	4	2	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr10:27702649C>T	uc001itu.2	-	1	649	c.531G>A	c.(529-531)CCG>CCA	p.P177P		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	177					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CCGCCTTGGCCGGGCTCCCCA	0.637													44	150					0	0	0	0	T	27702649	T	T	27702649	2	4	178	1	0	0	0	0	0	0	0	1	12796	639	23	1		1	PTCHD3	10	27702649	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08		27702649	107832098	33	33615											
KNDC1	85442	broad.mit.edu	37	chr10	135003312	135003312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaggagaggctggtaactGaaaaggtacccgggccctcc	11	5	14	11	1	0	3	0	1	0	2	1	4	1	3	3	5	2	3	3	5	4	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr10:135003312G>A	uc001llz.1	+	9	1571	c.1570G>A	c.(1570-1572)GAA>AAA	p.E524K	KNDC1_uc001lma.1_Missense_Mutation_p.E459K	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	524	KIND 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GCTGGTAACTGAAAAGGTACC	0.493													5	25					0	0	0	0	A	135003312	A	A	135003312	3	1	178	1	0	0	0	0	1	0	0	0	8465	1291	45	2	1604	2	KNDC1	10	135003312	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	107300663	135003312	531435	34	33616											
OR51G1	79324	broad.mit.edu	37	chr11	4944867	4944867	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttgagggctcggagtcgctCctggtgggaggcaatgctga	6	9	18	8	2	0	2	0	2	0	0	3	4	1	4	1	5	1	5	1	5	1	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr11:4944867C>A	uc010qyr.1	-	1	703	c.703G>T	c.(703-705)GAG>TAG	p.E235*		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CGGAGTCGCTCCTGGTGGGAG	0.552													26	68					3.69857e-22	4.25335e-22	1	0	A	4944867	A	A	4944867	4	1	178	1	0	0	0	0	0	1	0	0	11152	864	30	2	264	2	OR51G1	11	4944867	Nonsense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08		4944867	130061649	35	33617											
BTBD10	84280	broad.mit.edu	37	chr11	13410506	13410506	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctggtcctggggaatgtCtgctgcagctgctgcaagat	7	10	14	10	0	1	1	0	0	1	1	2	2	2	2	1	3	6	6	1	3	2	0			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr11:13410506C>A	uc001mkz.2	-	9	1557	c.1300G>T	c.(1300-1302)GAC>TAC	p.D434Y	BTBD10_uc010rcl.1_Missense_Mutation_p.D442Y|BTBD10_uc001mla.2_Missense_Mutation_p.D418Y|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Missense_Mutation_p.D386Y	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	434						nucleus					0				Epithelial(150;0.0214)		TGGGGAATGTCTGCTGCAGCT	0.488													48	77					2.6635e-43	3.1018e-43	1	0	A	13410506	A	A	13410506	3	1	178	1	0	0	0	0	1	0	0	0	1543	913	32	2	131	2	BTBD10	11	13410506	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	8465639	13410506	121596010	36	33618											
SLC43A3	29015	broad.mit.edu	37	chr11	57195235	57195236	+	5'Flank	INS	-	TATT	TATT																															gccagactgcattgattaacINScattcattgccccatttttt																								rs138882161	by1000genomes	TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr11:57195235_57195236insTATT	uc001nkg.2	-						SLC43A3_uc001nkh.2_5'Flank|SLC43A3_uc010rjr.1_5'Flank|SLC43A3_uc009yme.2_5'Flank|SLC43A3_uc001nki.2_5'Flank|SLC43A3_uc009ymf.1_5'Flank|SLC43A3_uc010rjs.1_5'Flank|SLC43A3_uc009ymg.1_5'Flank	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3						transmembrane transport	integral to membrane				central_nervous_system(1)	1						cattgattaaccattcattgcc	0.005													---	---	---								TATT	57195236	TATT	TATT	57195235	6	5	178	0	1	1	1	0	0	0	0	0	14698	522	18	0		0	SLC43A3	11	57195235	5'Flank	INS	-	TCGA-CV-5443-01A-01D-1512-08	43784729	57195235	77811281	37	33619											
MS4A15	219995	broad.mit.edu	37	chr11	60531293	60531293	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccacctccggccattctGcccacatccatgtgccaacc	7	8	6	20	1	1	0	0	0	1	0	3	0	3	0	8	1	4	0	8	1	1	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr11:60531293G>T	uc009ynf.1	+	2	307	c.87G>T	c.(85-87)CTG>CTT	p.L29L	MS4A15_uc001npx.2_Intron|MS4A15_uc001npy.2_RNA|MS4A15_uc009yng.1_Silent_p.L29L	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member	29						integral to membrane	receptor activity			lung(1)	1						CGGCCATTCTGCCCACATCCA	0.617													37	88					1.00953e-15	1.14663e-15	1	0	T	60531293	T	T	60531293	2	4	178	1	0	0	0	0	0	0	0	1	9912	1306	46	4		4	MS4A15	11	60531293	Silent	SNP	G	TCGA-CV-5443-01A-01D-1512-08	3336058	60531293	74475223	38	33620											
SCYL1	57410	broad.mit.edu	37	chr11	65303482	65303482	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactagggacccgtttgcacCgtcccgggttgcgggtgtcc	4	9	14	14	4	0	0	0	0	0	0	2	1	2	1	4	3	2	3	4	3	1	3			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr11:65303482C>A	uc001oea.1	+	11	1522	c.1445C>A	c.(1444-1446)CCG>CAG	p.P482Q	SCYL1_uc009yqk.2_Missense_Mutation_p.P482Q|SCYL1_uc001oeb.1_Missense_Mutation_p.P482Q|SCYL1_uc001oec.1_Missense_Mutation_p.P482Q|SCYL1_uc001oed.1_Missense_Mutation_p.P339Q|SCYL1_uc001oee.1_Missense_Mutation_p.P126Q	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	482					regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						CCGTTTGCACCGTCCCGGGTT	0.597													18	63					4.72057e-08	5.04991e-08	1	0	A	65303482	A	A	65303482	3	1	178	1	0	0	0	0	1	0	0	0	14012	652	23	3	1487	3	SCYL1	11	65303482	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	4772189	65303482	69703034	39	33621											
RCE1	9986	broad.mit.edu	37	chr11	66612399	66612399	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcggaaccaagtgatcGccccgctgacagaggagctg	9	5	15	12	3	0	3	0	2	0	1	1	5	0	5	3	3	3	3	3	3	2	0			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr11:66612399G>A	uc001ojk.1	+	5	555	c.511G>A	c.(511-513)GCC>ACC	p.A171T	RCE1_uc001ojl.1_Missense_Mutation_p.A67T	NM_005133	NP_005124	Q9Y256	FACE2_HUMAN	prenyl protein peptidase RCE1 isoform 1	171					proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			ovary(1)|breast(1)	2						CCAAGTGATCGCCCCGCTGAC	0.632													15	28					0	0	0	0	A	66612399	A	A	66612399	3	1	178	1	0	0	0	0	1	0	0	0	13241	1087	38	1	529	1	RCE1	11	66612399	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	1308917	66612399	68394117	40	33622											
SYTL2	54843	broad.mit.edu	37	chr11	85420460	85420460	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactccttcagtgactccacAtattcaattgcaaactgaat	14	12	4	11	0	2	2	2	2	0	0	4	2	4	2	2	0	3	1	2	0	5	4			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr11:85420460A>G	uc010rth.1	-	12	2190	c.1914T>C	c.(1912-1914)TAT>TAC	p.Y638Y	SYTL2_uc010rtg.1_Silent_p.Y639Y|SYTL2_uc010rti.1_Silent_p.Y614Y|SYTL2_uc010rtj.1_Silent_p.Y606Y|SYTL2_uc001pav.2_Silent_p.Y80Y|SYTL2_uc010rte.1_Silent_p.Y40Y|SYTL2_uc001pax.2_Silent_p.Y80Y|SYTL2_uc001paz.2_5'UTR|SYTL2_uc001pba.2_Silent_p.Y23Y|SYTL2_uc001pay.2_Silent_p.Y69Y|SYTL2_uc001paw.2_Silent_p.Y40Y|SYTL2_uc009yvj.2_RNA|SYTL2_uc001pbd.2_Silent_p.Y936Y|SYTL2_uc001pbb.2_Silent_p.Y976Y|SYTL2_uc001pbc.2_Silent_p.Y960Y|SYTL2_uc010rtf.1_Silent_p.Y456Y	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	638	C2 1.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		GTGACTCCACATATTCAATTG	0.408													6	121					0	0	0	0	G	85420460	G	G	85420460	2	3	178	1	0	0	0	0	0	0	0	1	15549	224	8	5		5	SYTL2	11	85420460	Silent	SNP	A	TCGA-CV-5443-01A-01D-1512-08	18808061	85420460	49586056	41	33623											
UBE4A	9354	broad.mit.edu	37	chr11	118263536	118263536	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatcccattatgagcacactGatgtgtgaccctgtggtgct	8	12	11	10	0	0	3	0	3	0	0	1	4	1	3	2	1	2	2	2	1	1	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr11:118263536G>A	uc001psw.2	+	19	3129	c.3000G>A	c.(2998-3000)CTG>CTA	p.L1000L	UBE4A_uc001psv.2_Silent_p.L1007L	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	1000	U-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TGAGCACACTGATGTGTGACC	0.483													56	86					0	0	0	0	A	118263536	A	A	118263536	2	1	178	1	0	0	0	0	0	0	0	1	16950	1277	45	2		2	UBE4A	11	118263536	Silent	SNP	G	TCGA-CV-5443-01A-01D-1512-08	32843076	118263536	16742980	42	33624											
MLF2	8079	broad.mit.edu	37	chr12	6859160	6859160	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaatcccgaacagtcctcCgtgtctcccggatctgggat	7	10	10	14	3	2	1	0	1	2	0	6	4	5	3	4	2	1	0	4	2	2	0			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr12:6859160C>T	uc010sfi.1	-	7	476	c.413G>A	c.(412-414)CGG>CAG	p.R138Q	MLF2_uc001qqp.2_Missense_Mutation_p.R138Q|MLF2_uc009zey.1_Missense_Mutation_p.R138Q	NM_005439	NP_005430	Q15773	MLF2_HUMAN	myeloid leukemia factor 2	138					defense response	cytoplasm|nucleus	protein binding			large_intestine(1)	1						AACAGTCCTCCGTGTCTCCCG	0.582													15	64					0	0	0	0	T	6859160	T	T	6859160	3	4	178	1	0	0	0	0	1	0	0	0	9669	652	23	1	341	1	MLF2	12	6859160	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08		6859160	126992735	43	33625											
LRP6	4040	broad.mit.edu	37	chr12	12334328	12334328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggtgtatccaaagaaatgCgtctcaagtctgtccttcga	10	12	9	10	2	2	1	1	0	2	1	6	2	4	1	2	1	1	1	2	1	4	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr12:12334328C>T	uc001rah.3	-	6	1164	c.1022G>A	c.(1021-1023)CGC>CAC	p.R341H	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.R341H	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	341	Extracellular (Potential).|Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding	p.R341H(1)		lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CAAAGAAATGCGTCTCAAGTC	0.403													34	81					0	0	0	0	T	12334328	T	T	12334328	3	4	178	1	0	0	0	0	1	0	0	0	9012	768	27	1	3891	1	LRP6	12	12334328	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	5475168	12334328	121517567	44	33626											
PTPRO	5800	broad.mit.edu	37	chr12	15699542	15699542	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	actcttcgcagtgaacaaaaCccagacttcagtgactttgc	12	10	7	12	1	2	3	1	2	1	1	3	3	2	3	1	0	3	1	1	0	3	3			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr12:15699542C>A	uc001rcv.1	+	13	2378	c.2204C>A	c.(2203-2205)ACC>AAC	p.T735N	PTPRO_uc001rcw.1_Missense_Mutation_p.T735N|PTPRO_uc001rcx.1_5'UTR|PTPRO_uc001rcy.1_5'UTR|PTPRO_uc001rcz.1_5'UTR|PTPRO_uc001rda.1_5'UTR	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	735	Fibronectin type-III 8.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GTGAACAAAACCCAGACTTCA	0.388													5	21					0.000602214	0.000636824	1	0	A	15699542	A	A	15699542	3	1	178	1	0	0	0	0	1	0	0	0	12874	507	18	4	2254	4	PTPRO	12	15699542	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	3365214	15699542	118152353	45	33627											
KRT83	3889	broad.mit.edu	37	chr12	52710276	52710276	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacttggcattctccacctcGgctgtcagcctctggatcat	6	12	8	15	1	4	0	2	0	2	0	6	1	4	1	3	3	1	2	3	3	0	2	rs143467763	byFrequency	TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr12:52710276G>A	uc001saf.2	-	6	1080	c.1017C>T	c.(1015-1017)GCC>GCT	p.A339A		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	339	Rod.|Coil 2.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCTCCACCTCGGCTGTCAGCC	0.597													33	50					0	0	0	0	A	52710276	A	A	52710276	2	1	178	1	0	0	0	0	0	0	0	1	8536	1103	39	1		1	KRT83	12	52710276	Silent	SNP	G	TCGA-CV-5443-01A-01D-1512-08	37010734	52710276	81141619	46	33628											
ZCCHC8	55596	broad.mit.edu	37	chr12	122975114	122975114	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctatttcttgatgatattgCctgtgtaagaggacaaaatg	12	15	9	5	0	2	3	0	2	2	1	2	4	2	4	1	1	1	1	1	1	5	6			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr12:122975114C>T	uc001ucn.2	-	4	449	c.318G>A	c.(316-318)AAG>AAA	p.K106K	ZCCHC8_uc009zxp.2_5'UTR|ZCCHC8_uc009zxq.2_5'UTR	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	106						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		GATGATATTGCCTGTGTAAGA	0.328													5	10					0	0	0	0	T	122975114	T	T	122975114	2	4	178	1	0	0	0	0	0	0	0	1	17661	753	26	4		4	ZCCHC8	12	122975114	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08	70264838	122975114	10876781	47	33629											
FREM2	341640	broad.mit.edu	37	chr13	39265211	39265211	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acatcatgaatcagctgataAatggcacggttttggtcgaa	13	11	10	7	2	2	2	2	2	0	0	3	3	2	2	0	3	1	3	0	3	4	3			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr13:39265211A>T	uc001uwv.2	+	1	4039	c.3730A>T	c.(3730-3732)AAT>TAT	p.N1244Y		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1244	CSPG 8.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TCAGCTGATAAATGGCACGGT	0.438													65	179					0	0	0	0	T	39265211	T	T	39265211	3	4	178	1	0	0	0	0	1	0	0	0	6079	14	1	5	3732	5	FREM2	13	39265211	Missense_Mutation	SNP	A	TCGA-CV-5443-01A-01D-1512-08		39265211	75904667	48	33630											
UCHL3	7347	broad.mit.edu	37	chr13	76134943	76134943	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aattcgttgatgtatatggaAtggatcctgaactccttagc	11	14	9	7	1	0	2	0	2	0	0	3	4	2	4	2	2	2	2	2	2	6	5			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr13:76134943A>G	uc001vjq.2	+	3	139	c.109A>G	c.(109-111)ATG>GTG	p.M37V	UCHL3_uc001vjr.2_Missense_Mutation_p.M1V	NM_006002	NP_005993	P15374	UCHL3_HUMAN	ubiquitin carboxyl-terminal esterase L3	37					ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity				0				GBM - Glioblastoma multiforme(99;0.0125)		TGTATATGGAATGGATCCTGA	0.338													25	75					0	0	0	0	G	76134943	G	G	76134943	3	3	178	1	0	0	0	0	1	0	0	0	16989	101	4	5	119	5	UCHL3	13	76134943	Missense_Mutation	SNP	A	TCGA-CV-5443-01A-01D-1512-08	36869732	76134943	39034935	49	33631											
CMTM5	116173	broad.mit.edu	37	chr14	23846483	23846483	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcagtgctcgagatcgccGggaccggcaccctgaggagg	7	5	16	13	4	1	2	1	1	0	1	3	5	1	4	3	4	1	3	3	4	0	0			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr14:23846483G>A	uc010akm.2	+	1	467	c.23G>A	c.(22-24)CGG>CAG	p.R8Q	CMTM5_uc001wjs.2_Missense_Mutation_p.R8Q|CMTM5_uc001wjt.2_Missense_Mutation_p.R8Q|CMTM5_uc010akn.2_Missense_Mutation_p.R8Q|CMTM5_uc001wju.2_Missense_Mutation_p.R8Q|CMTM5_uc010ako.2_RNA	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	8					chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		CGAGATCGCCGGGACCGGCAC	0.607													26	77					0	0	0	0	A	23846483	A	A	23846483	3	1	178	1	0	0	0	0	1	0	0	0	3601	1116	39	1	25	1	CMTM5	14	23846483	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08		23846483	83503057	50	33632											
ADAM20	8748	broad.mit.edu	37	chr14	70989374	70989374	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taataaaaaagcaaccaaagGaagaaggcacaatagtgaca	23	4	8	6	0	0	2	0	1	0	1	0	3	0	3	1	2	2	2	1	2	10	3			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr14:70989374G>A	uc001xme.2	-	2	2496	c.2251C>T	c.(2251-2253)CCT>TCT	p.P751S		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	701	Helical; (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GCAACCAAAGGAAGAAGGCAC	0.313													36	74					0	0	0	0	A	70989374	A	A	70989374	3	1	178	1	0	0	0	0	1	0	0	0	242	1174	41	2	83	2	ADAM20	14	70989374	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	47142891	70989374	36360166	51	33633											
BTBD7	55727	broad.mit.edu	37	chr14	93760396	93760396	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgtaatatcactgttgcatAtttttttggtataatggact	10	19	8	4	0	1	0	1	0	0	0	1	1	1	1	0	2	1	4	0	2	5	9			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr14:93760396A>G	uc001ybo.2	-	3	1296	c.970T>C	c.(970-972)TAT>CAT	p.Y324H	BTBD7_uc010aur.2_5'UTR|BTBD7_uc010two.1_Missense_Mutation_p.Y239H|BTBD7_uc001ybp.2_Intron|BTBD7_uc001ybq.3_Missense_Mutation_p.Y239H|BTBD7_uc001ybr.2_Missense_Mutation_p.Y324H	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	324	BTB 2.									pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACTGTTGCATATTTTTTTGGT	0.418													3	69					0	0	0	0	G	93760396	G	G	93760396	3	3	178	1	0	0	0	0	1	0	0	0	1551	449	16	5	2539	5	BTBD7	14	93760396	Missense_Mutation	SNP	A	TCGA-CV-5443-01A-01D-1512-08	22771022	93760396	13589144	52	33634											
AKT1	207	broad.mit.edu	37	chr14	105246551	105246551	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccgccaggtcttgatgtactCccctacagacgtgcgggtgg	6	9	13	13	3	1	2	0	1	1	1	2	2	2	2	4	3	3	1	4	3	2	3	rs34409589		TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr14:105246551C>T	uc001ypk.2	-	3	603	c.49G>A	c.(49-51)GAG>AAG	p.E17K	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Missense_Mutation_p.E17K|AKT1_uc010axa.2_Missense_Mutation_p.E17K|AKT1_uc001ypm.2_Missense_Mutation_p.E17K|AKT1_uc001ypn.2_Missense_Mutation_p.E17K|AKT1_uc010tyk.1_5'Flank	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	17	PH.		E -> K (in breast cancer; also detected in colorectal and ovarian cancer; somatic mutation; alters the PH domain conformation; results in activation of the protein; alters the subcellular location of the protein to the plasma membrane).	E->K: Increase in basal ubiquitination, phosphorylation at T-308 and important increase in membrane recruitment. Decrease in ubiquitination, phosphorylation at T-308 as well as impaired association with the membrane; when associated with R-8.	activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity	p.E17K(126)		breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	TTGATGTACTCCCCTACAGAC	0.612	E17K(KU1919_URINARY_TRACT)	1	Mis		breast|colorectal|ovarian|NSCLC								8	19					0	0	0	0	T	105246551	T	T	105246551	3	4	178	1	0	0	0	0	1	0	0	0	478	864	30	2	1441	2	AKT1	14	105246551	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	11486155	105246551	2102989	53	33635											
OR4N4	283694	broad.mit.edu	37	chr15	22383350	22383350	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatacccttcgcaaccaggAagtgaaaacttccatgaaga	15	9	7	10	1	0	3	0	2	0	1	2	4	1	4	3	1	3	1	3	1	7	4			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr15:22383350A>G	uc001yuc.1	+	7	1859	c.878A>G	c.(877-879)GAA>GGA	p.E293G	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.E293G	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CGCAACCAGGAAGTGAAAACT	0.408													16	140					0	0	0	0	G	22383350	G	G	22383350	3	3	178	1	0	0	0	0	1	0	0	0	11132	246	9	5	880	5	OR4N4	15	22383350	Missense_Mutation	SNP	A	TCGA-CV-5443-01A-01D-1512-08		22383350	80148042	54	33636											
MAP1A	4130	broad.mit.edu	37	chr15	43821897	43821897	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccctgtatatgtggatctCgcctacatcccgaatcattg	8	12	8	13	2	2	0	1	0	1	0	4	2	3	1	4	1	1	1	4	1	4	4			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr15:43821897C>T	uc001zrt.2	+	5	8552	c.8085C>T	c.(8083-8085)CTC>CTT	p.L2695L		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2695						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	ATGTGGATCTCGCCTACATCC	0.517													28	89					0	0	0	0	T	43821897	T	T	43821897	2	4	178	1	0	0	0	0	0	0	0	1	9280	871	31	1		1	MAP1A	15	43821897	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08	21438547	43821897	58709495	55	33637											
MYO9A	4649	broad.mit.edu	37	chr15	72186069	72186071	+	In_Frame_Del	DEL	TCT	-	-																															caggtttccatgctggttcaTcttctttatggagttgagga																								rs150726107	byFrequency	TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr15:72186069_72186071delTCT	uc002atl.3	-	26	5564_5566	c.5091_5093delAGA	c.(5089-5094)GAAGAT>GAT	p.E1697del	MYO9A_uc002atn.1_In_Frame_Del_p.E1678del|MYO9A_uc002atk.2_In_Frame_Del_p.E421del|MYO9A_uc002atm.1_In_Frame_Del_p.E421del	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1697	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TGCTGGTTCATCTTCTTTATGGA	0.355													---	---	---								-	72186071	-	-	72186069	7	5	178	1	0	1	0	1	0	0	0	0	10137	1435	50	0	2621	0	MYO9A	15	72186069	In_Frame_Del	DEL	TCT	TCGA-CV-5443-01A-01D-1512-08	28364172	72186069	30345323	56	33638											
LPCAT2	54947	broad.mit.edu	37	chr16	55579722	55579722	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaataaagtccggaatttaAtggcagagtaagtgtctata	15	11	9	6	1	1	1	0	0	1	1	2	2	2	2	2	2	0	2	2	2	8	6			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr16:55579722A>G	uc002eie.3	+	9	1109	c.928A>G	c.(928-930)ATG>GTG	p.M310V	LPCAT2_uc002eic.2_Missense_Mutation_p.M40V	NM_017839	NP_060309	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	310	Lumenal (Potential).				cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0						CCGGAATTTAATGGCAGAGTA	0.299													7	77					0	0	0	0	G	55579722	G	G	55579722	3	3	178	1	0	0	0	0	1	0	0	0	8961	101	4	5	962	5	LPCAT2	16	55579722	Missense_Mutation	SNP	A	TCGA-CV-5443-01A-01D-1512-08		55579722	34775031	57	33639											
SMYD4	114826	broad.mit.edu	37	chr17	1704289	1704289	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttctggatacccatgtgtCtgtgctctgttaatgtcttt	5	19	8	9	0	4	0	0	0	4	0	4	1	4	1	1	1	2	2	1	1	2	4			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr17:1704289C>T	uc002ftm.3	-	5	567	c.399G>A	c.(397-399)CAG>CAA	p.Q133Q	SMYD4_uc002ftn.1_5'UTR	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	133							zinc ion binding			skin(3)|kidney(2)	5						ACCCATGTGTCTGTGCTCTGT	0.443													53	155					0	0	0	0	T	1704289	T	T	1704289	2	4	178	1	0	0	0	0	0	0	0	1	14888	912	32	2		2	SMYD4	17	1704289	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08		1704289	79490921	58	33640											
DNAH9	1770	broad.mit.edu	37	chr17	11778325	11778325	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctgatggatgatgctgaCgtggctgcctggcagaacga	9	9	15	8	2	0	4	0	3	0	1	0	6	0	5	1	3	4	4	1	3	1	0			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr17:11778325C>T	uc002gne.2	+	53	10370	c.10302C>T	c.(10300-10302)GAC>GAT	p.D3434D	DNAH9_uc010coo.2_Silent_p.D2728D	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3434	AAA 5 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ATGATGCTGACGTGGCTGCCT	0.592													35	83					0	0	0	0	T	11778325	T	T	11778325	2	4	178	1	0	0	0	0	0	0	0	1	4630	535	19	1		1	DNAH9	17	11778325	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08	10074036	11778325	69416885	59	33641											
SUPT6H	6830	broad.mit.edu	37	chr17	27015218	27015218	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcttcctcaagatcgacaCggcctccctgggggacaggt	7	8	13	13	2	1	1	1	0	0	1	4	3	3	2	3	5	0	1	3	5	1	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr17:27015218C>T	uc002hby.2	+	24	3206	c.3116C>T	c.(3115-3117)ACG>ATG	p.T1039M	SUPT6H_uc010crt.2_Missense_Mutation_p.T1039M|SUPT6H_uc002hbz.1_5'Flank	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1039					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					AAGATCGACACGGCCTCCCTG	0.577													54	168					0	0	0	0	T	27015218	T	T	27015218	3	4	178	1	0	0	0	0	1	0	0	0	15466	536	19	1	3206	1	SUPT6H	17	27015218	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	15236893	27015218	54179992	60	33642											
DDX52	11056	broad.mit.edu	37	chr17	36003614	36003614	+	5'Flank	DEL	T	-	-																															gtactccgtcattatttatcTtttttttttttttttgaaac																										TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr17:36003614delT	uc002hoi.1	-						DDX52_uc002hoh.1_5'Flank|DDX52_uc002hoj.1_5'Flank	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a							nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				ATTAtttatcttttttttttt	0.244													---	---	---								-	36003614	-	-	36003614	6	5	178	0	1	1	0	1	0	0	0	0	4387	1624	56	0		0	DDX52	17	36003614	5'Flank	DEL	T	TCGA-CV-5443-01A-01D-1512-08	8988396	36003614	45191596	61	33643											
KRT13	3860	broad.mit.edu	37	chr17	39658663	39658663	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcaggctgcggtaggtggCgatctcctgctccagacgtg	6	8	16	11	3	1	1	0	0	1	1	3	3	2	1	2	4	3	4	2	4	1	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr17:39658663C>T	uc002hwu.1	-	6	1270	c.1207G>A	c.(1207-1209)GCC>ACC	p.A403T	KRT13_uc002hwv.1_Missense_Mutation_p.A403T|KRT13_uc002hww.2_Missense_Mutation_p.A296T|KRT13_uc010wfr.1_Missense_Mutation_p.A296T|KRT13_uc010cxo.2_Missense_Mutation_p.A403T|KRT13_uc002hwx.1_Missense_Mutation_p.A391T	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	403	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				CGGTAGGTGGCGATCTCCTGC	0.562													48	103					0	0	0	0	T	39658663	T	T	39658663	3	4	178	1	0	0	0	0	1	0	0	0	8489	768	27	1	181	1	KRT13	17	39658663	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08	3655049	39658663	41536547	62	33644											
GJC1	10052	broad.mit.edu	37	chr17	42885797	42885798	+	5'Flank	DEL	AC	-	-																															agaacaacaccctgtctcttAcacacacacacacacacaca																								rs71908859		TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr17:42885797_42885798delAC	uc002ihj.2	-						GJC1_uc002ihk.2_Intron|GJC1_uc002ihl.2_Intron|GJC1_uc010czx.2_Intron	NM_005497	NP_005488	P36383	CXG1_HUMAN	connexin 45						cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane					0		Prostate(33;0.0959)				CCTGTCTCTTacacacacacac	0.198													---	---	---								-	42885798	-	-	42885797	6	5	178	0	1	1	0	1	0	0	0	0	6451	406	14	0		0	GJC1	17	42885797	5'Flank	DEL	AC	TCGA-CV-5443-01A-01D-1512-08	3227134	42885797	38309413	63	33645											
PRCD	768206	broad.mit.edu	37	chr17	74522974	74522974	+	5'Flank	DEL	G	-	-																															cttggtgtgggacaggggatGgggcgcccttggtgtgggag																										TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr17:74522974delG	uc002jrw.1	+									Q00LT1	PRCD_HUMAN	Homo sapiens cDNA FLJ43629 fis, clone SPLEN2029727.						response to stimulus|visual perception	cytoplasm|integral to membrane					0						GACAGGGGATGGGGCGCCCTT	0.697													---	---	---								-	74522974	-	-	74522974	6	5	178	0	1	1	0	1	0	0	0	0	12510	1363	47	0		0	PRCD	17	74522974	5'Flank	DEL	G	TCGA-CV-5443-01A-01D-1512-08	31637177	74522974	6672236	64	33646											
CBX8	57332	broad.mit.edu	37	chr17	77769025	77769025	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctcgcttcttcgagctgtcCcccggtgagctgggcttgtc	2	12	12	15	3	1	1	0	1	1	0	5	2	2	1	3	2	2	4	3	2	0	3			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr17:77769025C>T	uc002jxd.1	-	5	672	c.579G>A	c.(577-579)GGG>GGA	p.G193G		NM_020649	NP_065700	Q9HC52	CBX8_HUMAN	chromobox homolog 8	193					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TCGAGCTGTCCCCCGGTGAGC	0.498													3	19					0	0	0	0	T	77769025	T	T	77769025	2	4	178	1	0	0	0	0	0	0	0	1	2736	632	22	4		4	CBX8	17	77769025	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08	3246051	77769025	3426185	65	33647											
LIPG	9388	broad.mit.edu	37	chr18	47110036	47110036	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagggggcctctcagtcttGgtacaacctgtggaaggagt	8	9	16	8	0	2	0	1	0	2	0	3	3	2	3	2	6	2	1	2	6	3	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr18:47110036G>A	uc002ldv.2	+	8	1520	c.1268G>A	c.(1267-1269)TGG>TAG	p.W423*	LIPG_uc010xdh.1_Nonsense_Mutation_p.W349*	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	423	PLAT.				cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						TCTCAGTCTTGGTACAACCTG	0.582													24	73					0	0	0	0	A	47110036	A	A	47110036	4	1	178	1	0	0	0	0	0	1	0	0	8865	1357	47	4	1298	4	LIPG	18	47110036	Nonsense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08		47110036	30967212	66	33648											
NOTCH3	4854	broad.mit.edu	37	chr19	15302992	15302992	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccacgtcgcttcggcagctgCggccctggtagccaggtggg	4	7	16	14	4	0	0	0	0	0	0	2	0	0	0	3	5	3	4	3	5	1	2			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr19:15302992C>T	uc002nan.2	-	4	534	c.458G>A	c.(457-459)CGC>CAC	p.R153H	NOTCH3_uc002nao.1_Missense_Mutation_p.R153H	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	153	Extracellular (Potential).|EGF-like 3.		Missing (in CADASIL).|R -> C (in CADASIL).		Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TCGGCAGCTGCGGCCCTGGTA	0.687													12	23					0	0	0	0	T	15302992	T	T	15302992	3	4	178	1	0	0	0	0	1	0	0	0	10604	768	27	1	6627	1	NOTCH3	19	15302992	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08		15302992	43825991	67	33649											
ZNF845	91664	broad.mit.edu	37	chr19	53854765	53854765	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaatgattgtggcaagacCttcagtcaggagttaaccct	11	12	10	8	0	2	2	2	1	0	1	2	3	2	3	2	2	1	3	2	2	3	4			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr19:53854765C>A	uc010ydv.1	+	4	954	c.837C>A	c.(835-837)ACC>ACA	p.T279T	ZNF845_uc010ydw.1_Silent_p.T279T	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	279	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTGGCAAGACCTTCAGTCAGG	0.423													18	58					2.48551e-13	2.78862e-13	1	0	A	53854765	A	A	53854765	2	1	178	1	0	0	0	0	0	0	0	1	18258	668	24	4		4	ZNF845	19	53854765	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08	38551773	53854765	5274218	68	33650											
TGM3	7053	broad.mit.edu	37	chr20	2297758	2297758	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcttgctgggaattggagCggcacttacaccggtggccg	6	9	16	10	3	0	0	0	0	0	0	0	2	0	2	2	5	4	3	2	5	2	3			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr20:2297758C>T	uc002wfx.3	+	6	811	c.714C>T	c.(712-714)AGC>AGT	p.S238S		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	238					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	GGAATTGGAGCGGCACTTACA	0.532													32	91					0	0	0	0	T	2297758	T	T	2297758	2	4	178	1	0	0	0	0	0	0	0	1	15897	767	27	1		1	TGM3	20	2297758	Silent	SNP	C	TCGA-CV-5443-01A-01D-1512-08		2297758	60727762	69	33651											
PRPF6	24148	broad.mit.edu	37	chr20	62631039	62631039	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctggattgcatcagcccGcctggaagaagtcactggga	10	7	13	11	1	2	1	2	0	0	1	2	4	2	4	3	3	3	1	3	3	2	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr20:62631039G>A	uc002yho.2	+	8	1118	c.950G>A	c.(949-951)CGC>CAC	p.R317H	PRPF6_uc002yhp.2_Missense_Mutation_p.R317H	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	317					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GCATCAGCCCGCCTGGAAGAA	0.557													20	28					0	0	0	0	A	62631039	A	A	62631039	3	1	178	1	0	0	0	0	1	0	0	0	12636	1087	38	1	980	1	PRPF6	20	62631039	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08	60333281	62631039	394481	70	33652											
ELFN2	114794	broad.mit.edu	37	chr22	37769728	37769728	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcgtcggcgctcagctggCgctgtagtgggtggtgggag	3	8	20	10	5	1	0	1	0	0	0	2	1	1	1	1	5	1	4	1	5	1	1			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chr22:37769728C>T	uc003asq.3	-	3	2633	c.1847G>A	c.(1846-1848)CGC>CAC	p.R616H		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	616	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					GCTCAGCTGGCGCTGTAGTGG	0.682													7	8					0	0	0	0	T	37769728	T	T	37769728	3	4	178	1	0	0	0	0	1	0	0	0	5082	768	27	1	619	1	ELFN2	22	37769728	Missense_Mutation	SNP	C	TCGA-CV-5443-01A-01D-1512-08		37769728	13534838	71	33653											
ASMT	438	broad.mit.edu	37	chrX	1755398	1755398	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gccagggtcctccatgactgGgcagacggaaagtgctcaca	10	6	13	12	1	1	2	1	1	0	1	3	3	3	3	3	3	1	2	3	3	1	0			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chrX:1755398G>C	uc004cqd.2	+	9	1000	c.855G>C	c.(853-855)TGG>TGC	p.W285C	ASMT_uc010ncy.2_Missense_Mutation_p.W285C|ASMT_uc004cqe.2_Missense_Mutation_p.W210C	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	257					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCCATGACTGGGCAGACGGAA	0.567													56	143					0	0	0	0	C	1755398	C	C	1755398	3	2	178	1	0	0	0	0	1	0	0	0	1047	1241	43	4	885	4	ASMT	23	1755398	Missense_Mutation	SNP	G	TCGA-CV-5443-01A-01D-1512-08		1755398	153515162	72	33654											
ARMCX5	64860	broad.mit.edu	37	chrX	101857876	101857876	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctttgaccaagatcccaccTtatcatgggccttattacca	10	12	5	14	0	1	2	1	1	0	1	2	2	2	2	6	1	1	0	6	1	4	4			TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chrX:101857876T>G	uc004ejg.2	+	6	1688	c.807T>G	c.(805-807)CCT>CCG	p.P269P	ARMCX5_uc004ejh.2_Silent_p.P269P	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	269							binding			ovary(1)	1						AGATCCCACCTTATCATGGGC	0.488													45	42					0	0	0	0	G	101857876	G	G	101857876	2	3	178	1	0	0	0	0	0	0	0	1	964	1596	56	5		5	ARMCX5	23	101857876	Silent	SNP	T	TCGA-CV-5443-01A-01D-1512-08	100102478	101857876	53412684	73	33655											
CXorf66	347487	broad.mit.edu	37	chrX	139047824	139047824	+	5'Flank	DEL	T	-	-																															tacaaattttaccaaatgacTtttttttttttttttttttt																										TCGA-CV-5443-01A-01D-1512-08	TCGA-CV-5443-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	9d279797-4464-4ef5-8858-640978ccc258	a5384389-3040-4d43-be4e-4794a870ce18	g.chrX:139047824delT	uc004fbb.2	-							NM_001013403	NP_001013421	Q5JRM2	CX066_HUMAN	hypothetical protein LOC347487 precursor							integral to membrane					0						ACCAAATGACttttttttttt	0.174													---	---	---								-	139047824	-	-	139047824	6	5	178	0	1	1	0	1	0	0	0	0	4135	1624	56	0		0	CXorf66	23	139047824	5'Flank	DEL	T	TCGA-CV-5443-01A-01D-1512-08	37189948	139047824	16222736	74	33656											
ATAD3A	55210	broad.mit.edu	37	chr1	1455561	1455561	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagctgcggcacaagaatgaGatgctgcgagtggaggccga	11	5	17	8	3	0	2	0	1	0	2	0	7	0	3	1	3	4	3	1	3	2	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:1455561G>A	uc001afz.1	+	6	793	c.699G>A	c.(697-699)GAG>GAA	p.E233E	ATAD3A_uc001aga.1_Silent_p.E185E|ATAD3A_uc001agb.1_Silent_p.E106E	NM_018188	NP_060658	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	233	Potential.						ATP binding|nucleoside-triphosphatase activity|protein binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		ACAAGAATGAGATGCTGCGAG	0.687													3	24					0	0	0	0	A	1455561	A	A	1455561	2	1	179	1	0	0	0	0	0	0	0	1	1075	933	33	2		2	ATAD3A	1	1455561	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08		1455561	247795060	1	33657											
CAMTA1	23261	broad.mit.edu	37	chr1	7737774	7737774	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgctcccttcctcccagcaCgactggctgtcgttggacgg	5	9	11	16	4	0	0	0	0	0	0	4	2	3	1	3	3	1	4	3	3	0	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:7737774C>T	uc001aoi.2	+	11	3102	c.2895C>T	c.(2893-2895)CAC>CAT	p.H965H	CAMTA1_uc010nzv.1_Silent_p.H52H|CAMTA1_uc001aok.3_5'Flank	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	965					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CCTCCCAGCACGACTGGCTGT	0.557													19	66					0	0	0	0	T	7737774	T	T	7737774	2	4	179	1	0	0	0	0	0	0	0	1	2625	535	19	1		1	CAMTA1	1	7737774	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	6282213	7737774	241512847	2	33658											
C1orf151	440574	broad.mit.edu	37	chr1	19950057	19950057	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttccaggctccatatcttCtacatggaaaatatgtcaaa	14	13	5	9	0	3	0	1	0	2	0	5	1	5	1	2	2	1	1	2	2	6	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:19950057C>G	uc001bci.1	+	3	275	c.202C>G	c.(202-204)CTA>GTA	p.L68V	C1orf151_uc001bch.1_RNA|NBL1_uc009vpl.1_Intron	NM_001032363	NP_001027535	Q5TGZ0	CA151_HUMAN	chromosome 1 open reading frame 151 protein	68						integral to membrane|mitochondrion				central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000323)|Lung NSC(340;0.000401)|Breast(348;0.00043)|Ovarian(437;0.00374)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.58e-05)|Kidney(64;0.000191)|GBM - Glioblastoma multiforme(114;0.000696)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		TCCATATCTTCTACATGGAAA	0.388													16	133					0	0	0	0	G	19950057	G	G	19950057	3	3	179	1	0	0	0	0	1	0	0	0	2014	912	32	2	212	2	C1orf151	1	19950057	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	12212283	19950057	229300564	3	33659											
HTR6	3362	broad.mit.edu	37	chr1	19992662	19992662	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctacaagctgcgcatgaCgcccctgcgtgccctggccc	5	6	12	18	4	0	1	0	1	0	0	0	1	0	1	4	1	5	3	4	1	2	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:19992662C>T	uc001bcl.2	+	1	883	c.416C>T	c.(415-417)ACG>ATG	p.T139M		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	139	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CTGCGCATGACGCCCCTGCGT	0.687													8	75					0	0	0	0	T	19992662	T	T	19992662	3	4	179	1	0	0	0	0	1	0	0	0	7490	536	19	1	418	1	HTR6	1	19992662	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	42605	19992662	229257959	4	33660											
MED18	54797	broad.mit.edu	37	chr1	28657231	28657231	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggggcaccattaacatgatgGagtacctgttgcagggtaag	11	9	14	7	0	0	1	0	1	0	0	0	2	0	2	2	4	3	5	2	4	3	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:28657231G>A	uc001bpt.3	+	2	303	c.58G>A	c.(58-60)GAG>AAG	p.E20K	MED18_uc009vtg.2_Missense_Mutation_p.E20K	NM_017638	NP_060108	Q9BUE0	MED18_HUMAN	mediator complex subunit 18	20					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	identical protein binding				0		Colorectal(325;0.000147)|Lung NSC(340;0.000818)|all_lung(284;0.000996)|Renal(390;0.00357)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0557)|Ovarian(437;0.113)		OV - Ovarian serous cystadenocarcinoma(117;2.36e-22)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0141)|READ - Rectum adenocarcinoma(331;0.0649)		TAACATGATGGAGTACCTGTT	0.483													7	34					0	0	0	0	A	28657231	A	A	28657231	3	1	179	1	0	0	0	0	1	0	0	0	9489	1175	41	2	60	2	MED18	1	28657231	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	8664569	28657231	220593390	5	33661											
ZMYM6	9204	broad.mit.edu	37	chr1	35480710	35480710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcagaaatctttgctaGgataggaattctcaaagcga	13	10	11	7	1	2	1	1	0	2	1	3	4	2	3	0	3	3	3	0	3	5	4	rs148778794		TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:35480710G>A	uc001byh.2	-	5	710	c.482C>T	c.(481-483)CCT>CTT	p.P161L	ZMYM6_uc001byf.1_Missense_Mutation_p.P161L|ZMYM6_uc010oht.1_Missense_Mutation_p.P64L|ZMYM6_uc009vup.2_5'UTR|ZMYM6_uc009vuq.1_Missense_Mutation_p.P161L|ZMYM6_uc009vur.1_5'UTR	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	161					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				ATCTTTGCTAGGATAGGAATT	0.323													12	38					0	0	0	0	A	35480710	A	A	35480710	3	1	179	1	0	0	0	0	1	0	0	0	17771	1000	35	4	3543	4	ZMYM6	1	35480710	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	6823479	35480710	213769911	6	33662											
INPP5B	3633	broad.mit.edu	37	chr1	38352663	38352663	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagcataatcccaaccagtCggataagcttcacctggaaa	14	7	8	12	1	1	0	1	0	0	0	3	2	2	2	3	2	3	3	3	2	4	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:38352663C>T	uc001ccg.1	-	12	1122	c.1028G>A	c.(1027-1029)CGA>CAA	p.R343Q	INPP5B_uc009vvk.1_Missense_Mutation_p.R284Q|INPP5B_uc001ccf.1_Missense_Mutation_p.R179Q|INPP5B_uc010oij.1_RNA	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	423					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CCCAACCAGTCGGATAAGCTT	0.453													8	77					0	0	0	0	T	38352663	T	T	38352663	3	4	179	1	0	0	0	0	1	0	0	0	7794	884	31	1	1765	1	INPP5B	1	38352663	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	2871953	38352663	210897958	7	33663											
ZNF642	339559	broad.mit.edu	37	chr1	40961662	40961662	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacgaatgtggaaaagccttCagctataactcttcacttag	14	11	7	9	1	3	0	2	0	1	0	3	2	3	1	1	1	4	1	1	1	7	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:40961662C>T	uc001cfo.2	+	6	1806	c.1512C>T	c.(1510-1512)TTC>TTT	p.F504F	ZNF642_uc009vwb.2_Silent_p.F504F|ZNF642_uc010ojk.1_Silent_p.F505F	NM_198494	NP_940896	Q49AA0	ZN642_HUMAN	zinc finger protein 642	504	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.81e-19)			GAAAAGCCTTCAGCTATAACT	0.388													21	54					0	0	0	0	T	40961662	T	T	40961662	2	4	179	1	0	0	0	0	0	0	0	1	18125	825	29	2		2	ZNF642	1	40961662	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	2608999	40961662	208288959	8	33664											
CYP4A22	284541	broad.mit.edu	37	chr1	47614372	47614372	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcctgatcccaccaggatccCcatccccatggcacgacttg	8	7	8	18	1	0	1	0	1	0	0	3	3	3	2	7	2	0	1	7	2	0	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:47614372C>G	uc001cqv.1	+	12	1514	c.1463C>G	c.(1462-1464)CCC>CGC	p.P488R		NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	488						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						ACCAGGATCCCCATCCCCATG	0.557													23	148					0	0	0	0	G	47614372	G	G	47614372	3	3	179	1	0	0	0	0	1	0	0	0	4201	623	22	4	1509	4	CYP4A22	1	47614372	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	6652710	47614372	201636249	9	33665											
PODN	127435	broad.mit.edu	37	chr1	53537247	53537247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctaccctgaggagctctcccGgctgcaccggctggagacgc	6	6	13	16	3	1	2	0	1	1	1	2	4	1	3	3	4	3	4	3	4	1	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:53537247G>A	uc001cuv.2	+	3	504	c.497G>A	c.(496-498)CGG>CAG	p.R166Q	PODN_uc001cuw.2_Missense_Mutation_p.R147Q|PODN_uc010onr.1_Missense_Mutation_p.R147Q|PODN_uc010ons.1_Intron	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	118	LRR 1.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						GAGCTCTCCCGGCTGCACCGG	0.637													4	16					0	0	0	0	A	53537247	A	A	53537247	3	1	179	1	0	0	0	0	1	0	0	0	12233	1116	39	1	507	1	PODN	1	53537247	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	5922875	53537247	195713374	10	33666											
LRP8	7804	broad.mit.edu	37	chr1	53736921	53736921	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccacaggtcttctggtccagGagctggaagcctgctgggca	7	8	14	12	0	2	0	0	0	2	0	3	2	3	2	3	5	3	3	3	5	1	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:53736921G>C	uc001cvi.1	-	7	1246	c.1104C>G	c.(1102-1104)CTC>CTG	p.L368L	LRP8_uc001cvh.1_5'UTR|LRP8_uc001cvk.1_Silent_p.L198L|LRP8_uc001cvj.1_Silent_p.L368L|LRP8_uc001cvl.1_Silent_p.L239L|LRP8_uc001cvm.1_5'Flank	NM_004631	NP_004622	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein	368	EGF-like 1.|Extracellular (Potential).				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0						TCTGGTCCAGGAGCTGGAAGC	0.577													7	109					0	0	0	0	C	53736921	C	C	53736921	2	2	179	1	0	0	0	0	0	0	0	1	9013	1161	41	2		2	LRP8	1	53736921	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	199674	53736921	195513700	11	33667											
DNAJC6	9829	broad.mit.edu	37	chr1	65845131	65845131	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcaggctcccagtctgcacaAcctttttgctgtgtgtcgga	6	12	11	12	1	1	0	0	0	1	0	3	1	2	1	2	2	3	4	2	2	1	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:65845131A>G	uc001dcd.1	+	5	583	c.419A>G	c.(418-420)AAC>AGC	p.N140S	DNAJC6_uc001dcc.1_Missense_Mutation_p.N171S|DNAJC6_uc010opc.1_Missense_Mutation_p.N127S|DNAJC6_uc001dce.1_Missense_Mutation_p.N197S	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	140	Phosphatase tensin-type.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						AGTCTGCACAACCTTTTTGCT	0.453													8	137					0	0	0	0	G	65845131	G	G	65845131	3	3	179	1	0	0	0	0	1	0	0	0	4675	43	2	5	437	5	DNAJC6	1	65845131	Missense_Mutation	SNP	A	TCGA-CV-5444-01A-02D-1512-08	12108210	65845131	183405490	12	33668											
LHX8	431707	broad.mit.edu	37	chr1	75622625	75622625	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacaagaaacacgtcagtccTaatcactcatcctccacccc	13	7	3	18	1	3	1	3	0	0	1	6	1	6	1	5	0	1	0	5	0	3	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:75622625T>G	uc001dgo.2	+	9	1522	c.858T>G	c.(856-858)CCT>CCG	p.P286P	LHX8_uc001dgq.2_Silent_p.P225P	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	286						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						ACGTCAGTCCTAATCACTCAT	0.512													22	114					0	0	0	0	G	75622625	G	G	75622625	2	3	179	1	0	0	0	0	0	0	0	1	8817	1509	53	5		5	LHX8	1	75622625	Silent	SNP	T	TCGA-CV-5444-01A-02D-1512-08	9777494	75622625	173627996	13	33669											
FUBP1	8880	broad.mit.edu	37	chr1	78444669	78444676	+	Frame_Shift_Del	DEL	ACTGTTGA	-	-																															agccagaagaggggggaggcActgttgaatagtctgccatg																								rs139086388	byFrequency	TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:78444669_78444676delACTGTTGA	uc001dii.2	-	1	102_109	c.13_20delTCAACAGT	c.(13-21)TCAACAGTGfs	p.S5fs	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Frame_Shift_Del_p.S5fs|DNAJB4_uc010orn.1_5'Flank	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	5_7					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						GGGGGGAGGCACTGTTGAATAGTCTGCC	0.462													---	---	---								-	78444676	-	-	78444669	7	5	179	1	0	1	0	1	0	0	0	0	6126	159	6	0	1994	0	FUBP1	1	78444669	Frame_Shift_Del	DEL	ACTGTTGA	TCGA-CV-5444-01A-02D-1512-08	2822044	78444669	170805952	14	33670											
CELSR2	1952	broad.mit.edu	37	chr1	109795151	109795151	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caatgcccctcagttcctgcGagactcctaccagggcagtg	8	8	10	15	1	1	1	1	0	0	1	3	2	3	1	5	1	3	2	5	1	2	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:109795151G>A	uc001dxa.3	+	1	2511	c.2450G>A	c.(2449-2451)CGA>CAA	p.R817Q		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	817	Extracellular (Potential).|Cadherin 7.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CAGTTCCTGCGAGACTCCTAC	0.552													10	79					0	0	0	0	A	109795151	A	A	109795151	3	1	179	1	0	0	0	0	1	0	0	0	3237	1058	37	1	2452	1	CELSR2	1	109795151	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	31350482	109795151	139455470	15	33671											
ATP5F1	515	broad.mit.edu	37	chr1	111996851	111996851	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agggtattgcaggcaacaagGacctttcatacagggcagcc	12	7	12	10	0	1	0	1	0	0	0	1	1	1	1	2	4	4	4	2	4	4	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:111996851G>C	uc001ebc.2	+	3	517	c.96G>C	c.(94-96)AGG>AGC	p.R32S	ATP5F1_uc009wgf.1_Missense_Mutation_p.R179S|ATP5F1_uc001ebd.3_Intron	NM_001688	NP_001679	P24539	AT5F1_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	32					ATP catabolic process|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding				0		all_cancers(81;8.16e-06)|all_epithelial(167;5.63e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGGCAACAAGGACCTTTCATA	0.418													9	71					0	0	0	0	C	111996851	C	C	111996851	3	2	179	1	0	0	0	0	1	0	0	0	1154	1165	41	2	106	2	ATP5F1	1	111996851	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	2201700	111996851	137253770	16	33672											
ITGA10	8515	broad.mit.edu	37	chr1	145538042	145538042	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctctctcctgagccaggtCttcgtgaagctgactgccag	6	11	10	14	1	2	3	0	3	2	0	6	3	4	3	4	1	3	1	4	1	1	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:145538042C>A	uc001eoa.2	+	22	2797	c.2721C>A	c.(2719-2721)GTC>GTA	p.V907V	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Silent_p.V776V|ITGA10_uc009wiw.2_Silent_p.V764V|ITGA10_uc010oyw.1_Silent_p.V852V	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	907	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGAGCCAGGTCTTCGTGAAGC	0.527													54	174					1.38658e-30	1.56778e-30	1	0	A	145538042	A	A	145538042	2	1	179	1	0	0	0	0	0	0	0	1	7912	900	32	2		2	ITGA10	1	145538042	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	33541191	145538042	103712579	17	33673											
TCHH	7062	broad.mit.edu	37	chr1	152085245	152085245	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcactttgctcctctccctCagctagctccctctcctgtt	3	15	4	19	0	4	0	2	0	2	0	8	0	6	0	4	0	3	4	4	0	1	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:152085245C>T	uc001ezp.2	-	2	448	c.448G>A	c.(448-450)GAG>AAG	p.E150K	TCHH_uc009wne.1_Missense_Mutation_p.E150K	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	150					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTCTCCCTCAGCTAGCTCC	0.582													41	184					0	0	0	0	T	152085245	T	T	152085245	3	4	179	1	0	0	0	0	1	0	0	0	15766	835	29	2	5387	2	TCHH	1	152085245	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	6547203	152085245	97165376	18	33674											
SYT2	127833	broad.mit.edu	37	chr1	202569513	202569513	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgcccacgtccatcttcttGaggttcttagcctccaggat	6	12	8	15	2	3	1	0	1	3	0	5	2	5	2	5	2	1	1	5	2	1	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:202569513G>C	uc001gye.2	-	7	1084	c.891C>G	c.(889-891)CTC>CTG	p.L297L	SYT2_uc010pqb.1_Silent_p.L297L|SYT2_uc009xaf.2_Silent_p.L127L	NM_001136504	NP_001129976	Q8N9I0	SYT2_HUMAN	synaptotagmin II	297	Phospholipid binding (By similarity).|C2 2.|Cytoplasmic (Potential).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	CCATCTTCTTGAGGTTCTTAG	0.617											OREG0014101	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	121					0	0	0	0	C	202569513	C	C	202569513	2	2	179	1	0	0	0	0	0	0	0	1	15540	1277	45	2		2	SYT2	1	202569513	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	50484268	202569513	46681108	19	33675											
FMOD	2331	broad.mit.edu	37	chr1	203316668	203316668	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtacagctgctcaagagctGagggcagcccatcaggcacc	10	6	12	13	0	2	2	2	1	0	1	2	2	2	2	2	2	5	6	2	2	2	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:203316668G>A	uc001gzr.2	-	2	867	c.731C>T	c.(730-732)TCA>TTA	p.S244L	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	244	LRR 6.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			CTCAAGAGCTGAGGGCAGCCC	0.587													18	162					0	0	0	0	A	203316668	A	A	203316668	3	1	179	1	0	0	0	0	1	0	0	0	5991	1294	45	2	407	2	FMOD	1	203316668	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	747155	203316668	45933953	20	33676											
CDC42BPA	8476	broad.mit.edu	37	chr1	227216783	227216783	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccagaagttacggtttgaCaccctttagtttctgacagc	9	14	8	10	1	1	3	0	2	1	1	2	3	2	3	2	1	2	3	2	1	3	6			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:227216783C>T	uc001hqr.2	-	29	4845	c.3902G>A	c.(3901-3903)TGT>TAT	p.C1301Y	CDC42BPA_uc001hqq.2_Missense_Mutation_p.C600Y|CDC42BPA_uc001hqs.2_Missense_Mutation_p.C1220Y|CDC42BPA_uc009xes.2_Missense_Mutation_p.C1273Y|CDC42BPA_uc010pvs.1_Missense_Mutation_p.C1281Y|CDC42BPA_uc001hqp.2_Missense_Mutation_p.C457Y|CDC42BPA_uc001hqt.2_Missense_Mutation_p.C179Y|CDC42BPA_uc001hqu.1_Missense_Mutation_p.C508Y	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	1314	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TACGGTTTGACACCCTTTAGT	0.468													5	51					0	0	0	0	T	227216783	T	T	227216783	3	4	179	1	0	0	0	0	1	0	0	0	3087	478	17	4	1289	4	CDC42BPA	1	227216783	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	23900115	227216783	22033838	21	33677											
SMYD3	64754	broad.mit.edu	37	chr1	246498710	246498710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagaagtcgaacggagtctgGaggatatctgggtttgcagc	11	9	15	6	2	2	1	0	0	2	1	3	5	2	4	0	4	3	2	0	4	4	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:246498710G>A	uc001ibl.2	-	3	390	c.295C>T	c.(295-297)CCA>TCA	p.P99S	SMYD3_uc001ibk.2_Missense_Mutation_p.P40S	NM_022743	NP_073580	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	99						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding				0	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		ACGGAGTCTGGAGGATATCTG	0.408													28	105					0	0	0	0	A	246498710	A	A	246498710	3	1	179	1	0	0	0	0	1	0	0	0	14887	1174	41	2	1031	2	SMYD3	1	246498710	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	19281927	246498710	2751911	22	33678											
ADAM17	6868	broad.mit.edu	37	chr2	9676833	9676833	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctccatactaaccaaccaCgtgtccagtgaagaagtcct	13	8	7	13	1	0	2	0	1	0	1	3	2	3	2	5	0	4	1	5	0	5	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:9676833C>T	uc002qzu.2	-	3	538	c.355G>A	c.(355-357)GTG>ATG	p.V119M	ADAM17_uc010ewy.2_Missense_Mutation_p.V119M|ADAM17_uc010ewz.2_Intron|ADAM17_uc010exb.1_Missense_Mutation_p.V119M|ADAM17_uc002qzv.2_Missense_Mutation_p.V119M	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	119					B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		TAACCAACCACGTGTCCAGTG	0.428													7	57					0	0	0	0	T	9676833	T	T	9676833	3	4	179	1	0	0	0	0	1	0	0	0	238	536	19	1	2187	1	ADAM17	2	9676833	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08		9676833	233522540	23	33679											
MRPL35	51318	broad.mit.edu	37	chr2	86433353	86433353	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacaccagttgtttcctcCactcccagacttaccacatc	10	10	4	17	0	0	2	0	0	0	2	4	2	3	2	5	0	1	2	5	0	1	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:86433353C>T	uc002srg.3	+	2	226	c.168C>T	c.(166-168)TCC>TCT	p.S56S	MRPL35_uc002srf.3_Silent_p.S56S	NM_016622	NP_057706	Q9NZE8	RM35_HUMAN	mitochondrial ribosomal protein L35 isoform a	56					translation	mitochondrial ribosome	structural constituent of ribosome				0						TTGTTTCCTCCACTCCCAGAC	0.418													20	127					0	0	0	0	T	86433353	T	T	86433353	2	4	179	1	0	0	0	0	0	0	0	1	9851	581	21	4		4	MRPL35	2	86433353	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	76756520	86433353	156766020	24	33680											
NCK2	8440	broad.mit.edu	37	chr2	106498121	106498121	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcgcaagggcgcctcgctGagcaatggccagggctcccg	6	5	15	15	4	0	1	0	1	0	0	2	1	1	1	3	3	2	4	3	3	2	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:106498121G>A	uc002tdg.2	+	4	1006	c.564G>A	c.(562-564)CTG>CTA	p.L188L	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Silent_p.L188L	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	188					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GCGCCTCGCTGAGCAATGGCC	0.647													12	94					0	0	0	0	A	106498121	A	A	106498121	2	1	179	1	0	0	0	0	0	0	0	1	10274	1277	45	2		2	NCK2	2	106498121	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	20064768	106498121	136701252	25	33681											
YSK4	80122	broad.mit.edu	37	chr2	135756548	135756548	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtgcttgtgcccattcttGaagcgatgagtttatcagac	9	14	10	8	1	2	3	1	2	1	1	2	4	2	3	1	0	3	2	1	0	2	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:135756548G>C	uc002tue.1	-	5	365	c.334C>G	c.(334-336)CAA>GAA	p.Q112E	YSK4_uc010fne.1_Missense_Mutation_p.Q84E|YSK4_uc002tuf.1_Missense_Mutation_p.Q112E|YSK4_uc010fnc.1_Missense_Mutation_p.Q112E|YSK4_uc010fnd.1_Intron|YSK4_uc010zbg.1_Missense_Mutation_p.Q112E|YSK4_uc002tui.3_Missense_Mutation_p.Q129E	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	112							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GCCCATTCTTGAAGCGATGAG	0.443													9	61					0	0	0	0	C	135756548	C	C	135756548	3	2	179	1	0	0	0	0	1	0	0	0	17563	1299	45	2	3676	2	YSK4	2	135756548	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	29258427	135756548	107442825	26	33682											
BAZ2B	29994	broad.mit.edu	37	chr2	160241870	160241870	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcagcaaatgttctccaagaGctgttttagcctataaaagt	13	13	7	8	0	2	1	1	0	1	1	3	1	2	1	2	0	3	4	2	0	6	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:160241870G>C	uc002uao.2	-	23	3834	c.3482C>G	c.(3481-3483)GCT>GGT	p.A1161G	BAZ2B_uc002uap.2_Missense_Mutation_p.A1125G	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TTCTCCAAGAGCTGTTTTAGC	0.323													4	46					0	0	0	0	C	160241870	C	C	160241870	3	2	179	1	0	0	0	0	1	0	0	0	1334	971	34	4	3084	4	BAZ2B	2	160241870	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	24485322	160241870	82957503	27	33683											
SCN3A	6328	broad.mit.edu	37	chr2	165949010	165949010	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttgtctggttacaaaatCaaagaccattccttggaatt	13	13	7	8	0	2	1	1	0	1	1	3	3	3	2	2	2	1	1	2	2	5	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:165949010C>G	uc002ucx.2	-	27	5053	c.4561G>C	c.(4561-4563)GAT>CAT	p.D1521H	SCN3A_uc010zcy.1_Missense_Mutation_p.D4H|SCN3A_uc002ucy.2_Missense_Mutation_p.D1472H|SCN3A_uc002ucz.2_Missense_Mutation_p.D1472H	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1521						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GTTACAAAATCAAAGACCATT	0.353													16	56					0	0	0	0	G	165949010	G	G	165949010	3	3	179	1	0	0	0	0	1	0	0	0	13983	826	29	2	1449	2	SCN3A	2	165949010	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	5707140	165949010	77250363	28	33684											
FARP2	9855	broad.mit.edu	37	chr2	242407683	242407683	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtctgctacttgcctctCaacacgttcctgctgaagcc	8	11	8	14	1	2	1	1	1	2	0	4	1	3	1	3	1	6	3	3	1	4	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:242407683C>T	uc002wbi.1	+	18	2139	c.2022C>T	c.(2020-2022)CTC>CTT	p.L674L		NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	674	DH.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		ACTTGCCTCTCAACACGTTCC	0.567													9	53					0	0	0	0	T	242407683	T	T	242407683	2	4	179	1	0	0	0	0	0	0	0	1	5709	813	29	2		2	FARP2	2	242407683	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	76458673	242407683	791690	29	33685											
CPNE9	151835	broad.mit.edu	37	chr3	9747714	9747714	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggccctgggagaggtgattgGaggccagggcagccgagtag	8	5	20	8	1	0	2	0	1	0	1	0	5	0	3	3	6	1	2	3	6	1	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:9747714G>C	uc003bsd.2	+	6	515	c.344G>C	c.(343-345)GGA>GCA	p.G115A		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	115										ovary(2)	2	Medulloblastoma(99;0.227)					GAGGTGATTGGAGGCCAGGGC	0.587													4	44					0	0	0	0	C	9747714	C	C	9747714	3	2	179	1	0	0	0	0	1	0	0	0	3834	1174	41	2	366	2	CPNE9	3	9747714	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08		9747714	188274716	30	33686											
IL17RE	132014	broad.mit.edu	37	chr3	9945094	9945094	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcaggatgacagtttcaCtggtgagtcgcatttcctgc	7	12	11	11	1	2	2	2	2	0	0	4	3	3	3	2	2	1	2	2	2	0	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:9945094C>A	uc003btu.2	+	3	263	c.146C>A	c.(145-147)ACT>AAT	p.T49N	CIDEC_uc003bto.2_Intron|IL17RE_uc003btv.2_Missense_Mutation_p.T49N|IL17RE_uc011atn.1_Intron|IL17RE_uc003btw.2_Missense_Mutation_p.T49N|IL17RE_uc003btx.2_Intron|IL17RE_uc010hcq.2_Missense_Mutation_p.T49N|IL17RE_uc003bty.2_Intron	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	49	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GACAGTTTCACTGGTGAGTCG	0.512													10	38					1.61879e-10	1.78966e-10	1	0	A	9945094	A	A	9945094	3	1	179	1	0	0	0	0	1	0	0	0	7682	565	20	4	152	4	IL17RE	3	9945094	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	197380	9945094	188077336	31	33687											
TGFBR2	7048	broad.mit.edu	37	chr3	30729875	30729875	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttgctggctttcttcacaGaagtaaaagattatgagcct	11	14	9	7	0	2	3	1	1	1	2	2	3	2	3	1	1	2	4	1	1	4	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:30729875G>A	uc003ceo.2	+	6	1779	c.1397_splice	c.e6-1	p.E466_splice	TGFBR2_uc003cen.2_Splice_Site_p.E491_splice	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II						activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						TTTCTTCACAGAAGTAAAAGA	0.512													15	70					0	0	0	0	A	30729875	A	A	30729875	5	1	179	1	0	0	0	0	0	0	1	0	15888	956	33	2	1497	2	TGFBR2	3	30729875	Splice_Site	SNP	G	TCGA-CV-5444-01A-02D-1512-08	20784781	30729875	167292555	32	33688											
TGFBR2	7048	broad.mit.edu	37	chr3	30729917	30729917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catttggttccaaggtgcggGagcacccctgtgtcgaaagc	8	9	13	11	2	0	0	0	0	0	0	2	2	1	1	3	3	3	2	3	3	2	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:30729917G>A	uc003ceo.2	+	6	1820	c.1438G>A	c.(1438-1440)GAG>AAG	p.E480K	TGFBR2_uc003cen.2_Missense_Mutation_p.E505K	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	480	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CAAGGTGCGGGAGCACCCCTG	0.507													15	68					0	0	0	0	A	30729917	A	A	30729917	3	1	179	1	0	0	0	0	1	0	0	0	15888	1175	41	2	1539	2	TGFBR2	3	30729917	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	42	30729917	167292513	33	33689											
ROBO2	6092	broad.mit.edu	37	chr3	77666731	77666731	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacaccaaggtctggaagatGaactggaagaagatgatgat	16	8	12	5	0	1	6	0	3	1	3	1	8	1	8	1	3	2	0	1	3	6	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:77666731G>C	uc003dpy.3	+	22	4004	c.3361G>C	c.(3361-3363)GAA>CAA	p.E1121Q	ROBO2_uc003dpz.2_Missense_Mutation_p.E1125Q|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.E1125Q|ROBO2_uc003dqa.2_Missense_Mutation_p.E248Q	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1121	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TCTGGAAGATGAACTGGAAGA	0.458													16	55					0	0	0	0	C	77666731	C	C	77666731	3	2	179	1	0	0	0	0	1	0	0	0	13579	1291	45	2	3449	2	ROBO2	3	77666731	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	46936814	77666731	120355699	34	33690											
PVRL3	25945	broad.mit.edu	37	chr3	110845177	110845177	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaccaaaaagtcatctacaTttcaggtaagttactatctg	14	13	6	8	0	4	1	2	1	2	0	4	1	4	1	1	1	2	2	1	1	6	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:110845177T>C	uc003dxt.1	+	5	1064	c.1064T>C	c.(1063-1065)ATT>ACT	p.I355T	PVRL3_uc003dxu.1_Missense_Mutation_p.I332T	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	355	Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						GTCATCTACATTTCAGGTAAG	0.299													13	42					0	0	0	0	C	110845177	C	C	110845177	3	2	179	1	0	0	0	0	1	0	0	0	12906	1493	52	5	1082	5	PVRL3	3	110845177	Missense_Mutation	SNP	T	TCGA-CV-5444-01A-02D-1512-08	33178446	110845177	87177253	35	33691											
GAP43	2596	broad.mit.edu	37	chr3	115395104	115395104	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactactgccgaagcagcccCagccactggctccaagcctg	9	5	9	18	1	0	0	0	0	0	0	1	1	1	0	6	1	6	2	6	1	3	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:115395104C>T	uc003ebq.2	+	2	661	c.275C>T	c.(274-276)CCA>CTA	p.P92L	GAP43_uc003ebr.2_Missense_Mutation_p.P128L	NM_002045	NP_002036	P17677	NEUM_HUMAN	growth associated protein 43 isoform 2	92					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)		GAAGCAGCCCCAGCCACTGGC	0.602													6	47					0	0	0	0	T	115395104	T	T	115395104	3	4	179	1	0	0	0	0	1	0	0	0	6270	594	21	4	423	4	GAP43	3	115395104	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	4549927	115395104	82627326	36	33692											
ZNF148	7707	broad.mit.edu	37	chr3	124998088	124998088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccatcctcatttattgtaaGgatctagttcaaaaaaaaaa	17	13	4	7	0	3	0	2	0	1	0	5	1	5	1	2	1	0	2	2	1	8	6			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:124998088G>A	uc003ehx.3	-	6	949	c.463C>T	c.(463-465)CTT>TTT	p.L155F	SLC12A8_uc003ehw.3_5'UTR|ZNF148_uc003ehz.3_Missense_Mutation_p.L155F|ZNF148_uc010hsa.2_Missense_Mutation_p.L155F|ZNF148_uc003eia.3_Missense_Mutation_p.L155F|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	155					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						TTTATTGTAAGGATCTAGTTC	0.299													31	48					0	0	0	0	A	124998088	A	A	124998088	3	1	179	1	0	0	0	0	1	0	0	0	17801	1000	35	4	1937	4	ZNF148	3	124998088	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	9602984	124998088	73024342	37	33693											
RASA2	5922	broad.mit.edu	37	chr3	141231006	141231006	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaattttatgccaacaggTgaagcaaaaaatttattgcc	16	13	6	6	0	0	1	0	1	0	0	0	1	0	1	2	1	4	1	2	1	9	6			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:141231006T>A	uc003etz.1	+	2	135	c.135T>A	c.(133-135)TGT>TGA	p.C45*	RASA2_uc010huq.1_Nonsense_Mutation_p.C45*|RASA2_uc003eua.1_Nonsense_Mutation_p.C45*	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	45	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						TGCCAACAGGTGAAGCAAAAA	0.323													15	45					0	0	0	0	A	141231006	A	A	141231006	4	1	179	1	0	0	0	0	0	1	0	0	13126	1710	59	5	141	5	RASA2	3	141231006	Nonsense_Mutation	SNP	T	TCGA-CV-5444-01A-02D-1512-08	16232918	141231006	56791424	38	33694											
IGSF10	285313	broad.mit.edu	37	chr3	151166371	151166371	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtccatttgtgtttcactggCctcatctctgctcttggtaa	5	17	8	11	0	4	0	2	0	2	0	6	0	5	0	2	2	1	3	2	2	1	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:151166371C>T	uc011bod.1	-	4	1398	c.1398G>A	c.(1396-1398)AGG>AGA	p.R466R		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	466	Ig-like C2-type 1.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTTTCACTGGCCTCATCTCTG	0.453													33	162					0	0	0	0	T	151166371	T	T	151166371	2	4	179	1	0	0	0	0	0	0	0	1	7636	738	26	4		4	IGSF10	3	151166371	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	9935365	151166371	46856059	39	33695											
MAP6D1	79929	broad.mit.edu	37	chr3	183535851	183535851	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgactcgggctggttttgtCtttgtggatcttgagggctt	4	17	14	6	1	2	2	0	2	2	0	3	3	2	3	0	4	0	3	0	4	0	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:183535851C>T	uc003fmc.2	-	2	508	c.450G>A	c.(448-450)AAG>AAA	p.K150K		NM_024871	NP_079147	Q9H9H5	MA6D1_HUMAN	MAP6 domain containing 1	150						cytoskeleton					0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;5.15e-42)|Epithelial(37;4.29e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CTGGTTTTGTCTTTGTGGATC	0.582													11	112					0	0	0	0	T	183535851	T	T	183535851	2	4	179	1	0	0	0	0	0	0	0	1	9318	912	32	2		2	MAP6D1	3	183535851	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	32369480	183535851	14486579	40	33696											
PRKG2	5593	broad.mit.edu	37	chr4	82056396	82056396	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcgatgcaggtaatcaaaTgcttctgtcacacaagcaac	14	9	8	10	1	3	0	2	0	1	0	4	1	3	0	0	1	4	4	0	1	4	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr4:82056396T>A	uc003hmh.2	-	13	1703	c.1689A>T	c.(1687-1689)GCA>GCT	p.A563A	PRKG2_uc011ccf.1_Silent_p.A143A|PRKG2_uc011ccg.1_Silent_p.A143A|PRKG2_uc011cch.1_Silent_p.A534A	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	563	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						GGTAATCAAATGCTTCTGTCA	0.388													12	61					0	0	0	0	A	82056396	A	A	82056396	2	1	179	1	0	0	0	0	0	0	0	1	12585	1451	51	5		5	PRKG2	4	82056396	Silent	SNP	T	TCGA-CV-5444-01A-02D-1512-08		82056396	109097880	41	33697											
MTTP	4547	broad.mit.edu	37	chr4	100532392	100532392	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctgcctacactggctacaTagaacgtatgtacaccaaaa	14	10	6	11	1	1	1	0	0	1	1	1	1	1	1	2	1	5	3	2	1	8	6			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr4:100532392T>C	uc003hvc.3	+	14	2118	c.1862T>C	c.(1861-1863)ATA>ACA	p.I621T	MTTP_uc011cej.1_Missense_Mutation_p.I648T	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	621	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	ACTGGCTACATAGAACGTATG	0.433													15	89					0	0	0	0	C	100532392	C	C	100532392	3	2	179	1	0	0	0	0	1	0	0	0	10017	1406	49	5	1912	5	MTTP	4	100532392	Missense_Mutation	SNP	T	TCGA-CV-5444-01A-02D-1512-08	18475996	100532392	90621884	42	33698											
FAT4	79633	broad.mit.edu	37	chr4	126238826	126238826	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgccgaacctgagcctaatCaaggtggccagcgccttgga	9	7	13	12	2	1	1	1	1	0	0	1	3	1	2	5	3	4	0	5	3	3	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr4:126238826C>G	uc003ifj.3	+	1	1260	c.1260C>G	c.(1258-1260)ATC>ATG	p.I420M		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	420	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGAGCCTAATCAAGGTGGCCA	0.607											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	30					0	0	0	0	G	126238826	G	G	126238826	3	3	179	1	0	0	0	0	1	0	0	0	5724	816	29	2	1262	2	FAT4	4	126238826	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	25706434	126238826	64915450	43	33699											
GYPB	2994	broad.mit.edu	37	chr4	144920591	144920591	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaaacgatggacaagttGtcccgtttctcctataaagc	12	11	9	9	2	1	1	0	1	1	0	3	3	2	2	2	1	2	2	2	1	5	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr4:144920591G>C	uc003ijm.1	-	3	204	c.148C>G	c.(148-150)CAA>GAA	p.Q50E	GYPA_uc003ijn.2_Intron|GYPB_uc011chs.1_RNA|GYPB_uc011cht.1_RNA|GYPB_uc011chu.1_RNA|GYPB_uc010ioo.1_RNA|GYPB_uc010iop.2_RNA|GYPB_uc011chv.1_RNA|GYPB_uc011chw.1_RNA|GYPB_uc011chx.1_Intron|GYPB_uc011chy.1_RNA|GYPB_uc011chz.1_RNA	NM_002100	NP_002091	P06028	GLPB_HUMAN	glycophorin B precursor	50	Extracellular (Potential).					integral to plasma membrane					0	all_hematologic(180;0.158)					TGGACAAGTTGTCCCGTTTCT	0.328													5	6					0	0	0	0	C	144920591	C	C	144920591	3	2	179	1	0	0	0	0	1	0	0	0	6948	1386	48	4	139	4	GYPB	4	144920591	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	18681765	144920591	46233685	44	33700											
TRIM61	391712	broad.mit.edu	37	chr4	165891361	165891361	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttcagagtctactgccaCgaacacttcacagcctgcag	11	8	8	14	1	3	1	2	0	1	1	3	2	3	1	2	0	6	2	2	0	2	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr4:165891361C>T	uc003iqw.2	-	3	405	c.-206G>A	c.(-208--204)TCGTG>TCATG			NM_001012414	NP_001012414	Q5EBN2	TRI61_HUMAN	tripartite motif-containing 61							intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.155)		TCTACTGCCACGAACACTTCA	0.418													2	2					0	0	0	0	T	165891361	T	T	165891361	1	4	179	1	0	0	0	0	0	0	0	0	16603	551	19	1		1	TRIM61	4	165891361	Translation_Start_Site	SNP	C	TCGA-CV-5444-01A-02D-1512-08	20970770	165891361	25262915	45	33701											
CTNND2	1501	broad.mit.edu	37	chr5	11364901	11364901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggggcttctgatagacgcGgtcttcatagatgggatcta	9	11	14	7	2	4	3	1	1	3	2	4	4	4	4	0	4	0	1	0	4	3	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:11364901G>A	uc003jfa.1	-	8	1424	c.1279C>T	c.(1279-1281)CGC>TGC	p.R427C	CTNND2_uc010itt.2_Missense_Mutation_p.R336C|CTNND2_uc011cmy.1_Missense_Mutation_p.R90C|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	427	ARM 1.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGATAGACGCGGTCTTCATAG	0.622													16	49					0	0	0	0	A	11364901	A	A	11364901	3	1	179	1	0	0	0	0	1	0	0	0	4037	1116	39	1	2458	1	CTNND2	5	11364901	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08		11364901	169550359	46	33702											
TTC33	23548	broad.mit.edu	37	chr5	40747015	40747015	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaagccagttcccttcatCgttgtcaactacatccttct	9	14	5	13	1	3	1	2	1	1	0	6	1	5	1	3	0	3	2	3	0	3	5	rs142188985		TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:40747015C>T	uc003jma.2	-	2	254	c.106G>A	c.(106-108)GAT>AAT	p.D36N	TTC33_uc011cpm.1_5'UTR|TTC33_uc010ivg.2_Missense_Mutation_p.D36N	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	36							binding			ovary(1)	1						TTCCCTTCATCGTTGTCAACT	0.443													3	32					0	0	0	0	T	40747015	T	T	40747015	3	4	179	1	0	0	0	0	1	0	0	0	16770	884	31	1	698	1	TTC33	5	40747015	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	29382114	40747015	140168245	47	33703											
TAF9	6880	broad.mit.edu	37	chr5	68660786	68660806	+	In_Frame_Del	DEL	TCATCATCATCATCATCGTCA	-	-																															tagattacagattatcatagTcatcatcatcatcatcgtca																								rs149295876		TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:68660786_68660806delTCATCATCATCATCATCGTCA	uc003jwc.1	-	2	1091_1111	c.759_779delTGACGATGATGATGATGATGA	c.(757-780)GATGACGATGATGATGATGATGAC>GAC	p.253_260DDDDDDDD>D	TAF9_uc003jwa.2_Intron|TAF9_uc003jwb.2_Intron|TAF9_uc003jwd.1_In_Frame_Del_p.253_260DDDDDDDD>D|TAF9_uc003jwe.1_In_Frame_Del_p.253_260DDDDDDDD>D|TAF9_uc003jwf.1_In_Frame_Del_p.253_260DDDDDDDD>D	NM_003187	NP_003178	Q16594	TAF9_HUMAN	TAF9 RNA polymerase II, TATA box binding	253_260	Poly-Asp.				histone H3 acetylation|negative regulation of apoptosis|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cell growth|positive regulation of response to cytokine stimulus|positive regulation of transcription from RNA polymerase II promoter|response to interleukin-1|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	MLL1 complex|PCAF complex|pre-snoRNP complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	activating transcription factor binding|C2H2 zinc finger domain binding|p53 binding|transcription coactivator activity|transcription regulatory region DNA binding				0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		attatcatagtcatcatcatcatcatcgtcatcatcatcat	0.262													---	---	---								-	68660806	-	-	68660786	7	5	179	1	0	1	0	1	0	0	0	0	15601	1667	58	0	429	0	TAF9	5	68660786	In_Frame_Del	DEL	TCATCATCATCATCATCGTCA	TCGA-CV-5444-01A-02D-1512-08	27913771	68660786	112254474	48	33704											
PCDHB6	56130	broad.mit.edu	37	chr5	140531980	140531980	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcggtgcggctgtgcaggagGagcagggcggcctcggtggg	4	5	23	9	4	0	0	0	0	0	0	1	2	0	2	1	8	3	3	1	8	0	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:140531980G>A	uc003lir.2	+	1	2142	c.2142G>A	c.(2140-2142)AGG>AGA	p.R714R	PCDHB6_uc011dah.1_Silent_p.R578R	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	714	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTGCAGGAGGAGCAGGGCGG	0.662													16	155					0	0	0	0	A	140531980	A	A	140531980	2	1	179	1	0	0	0	0	0	0	0	1	11600	1165	41	2		2	PCDHB6	5	140531980	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	71871194	140531980	40383280	49	33705											
PCDHB7	56129	broad.mit.edu	37	chr5	140553835	140553835	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccctgcccatcggcagtgtCagcgccacagacagagactc	9	5	11	16	2	1	2	1	0	0	2	3	3	1	2	3	1	2	1	3	1	0	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:140553835C>T	uc003lit.2	+	1	1593	c.1419C>T	c.(1417-1419)GTC>GTT	p.V473V		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	473	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGCAGTGTCAGCGCCACAG	0.637													6	85					0	0	0	0	T	140553835	T	T	140553835	2	4	179	1	0	0	0	0	0	0	0	1	11601	813	29	2		2	PCDHB7	5	140553835	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	21855	140553835	40361425	50	33706											
PCDHB12	56124	broad.mit.edu	37	chr5	140589072	140589072	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccctgagttagttctggacaAggcgctggattatgaagagc	10	10	13	8	1	1	3	0	2	1	1	1	5	1	5	1	3	1	3	1	3	4	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:140589072A>T	uc003liz.2	+	1	782	c.593A>T	c.(592-594)AAG>ATG	p.K198M	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	198	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCTGGACAAGGCGCTGGAT	0.488													14	56					0	0	0	0	T	140589072	T	T	140589072	3	4	179	1	0	0	0	0	1	0	0	0	11591	72	3	5	595	5	PCDHB12	5	140589072	Missense_Mutation	SNP	A	TCGA-CV-5444-01A-02D-1512-08	35237	140589072	40326188	51	33707											
PCYOX1L	78991	broad.mit.edu	37	chr5	148745675	148745675	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcgtttctgctgtcctgcGggccagctatggccagtcag	4	12	13	12	2	2	0	1	0	1	0	4	0	3	0	3	2	3	3	3	2	1	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:148745675G>T	uc003lqk.2	+	4	703	c.641G>T	c.(640-642)CGG>CTG	p.R214L	PCYOX1L_uc003lql.2_Missense_Mutation_p.R197L|PCYOX1L_uc010jgz.2_Intron|PCYOX1L_uc003lqm.2_Missense_Mutation_p.R96L|PCYOX1L_uc003lqn.2_Missense_Mutation_p.R124L	NM_024028	NP_076933	Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like precursor	214					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGTCCTGCGGGCCAGCTAT	0.597													10	35					0.000673444	0.000697997	1	0	T	148745675	T	T	148745675	3	4	179	1	0	0	0	0	1	0	0	0	11663	1116	39	3	655	3	PCYOX1L	5	148745675	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	8156603	148745675	32169585	52	33708											
CNOT8	9337	broad.mit.edu	37	chr5	154250259	154250259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggattccatagatctccttgCtaactcaggactacagtttc	10	13	7	11	0	2	1	1	0	1	1	5	3	3	3	2	2	3	2	2	2	3	6			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:154250259C>T	uc003lvu.2	+	5	829	c.350C>T	c.(349-351)GCT>GTT	p.A117V	CNOT8_uc011ddf.1_Missense_Mutation_p.A11V|CNOT8_uc011ddg.1_Missense_Mutation_p.A11V|CNOT8_uc011ddh.1_Intron|CNOT8_uc003lvv.2_Missense_Mutation_p.A117V|CNOT8_uc010jig.2_Missense_Mutation_p.A11V|CNOT8_uc010jif.2_Missense_Mutation_p.A11V|CNOT8_uc003lvw.2_Missense_Mutation_p.A117V|CNOT8_uc011ddi.1_Missense_Mutation_p.A11V|CNOT8_uc011ddj.1_Intron	NM_004779	NP_004770	Q9UFF9	CNOT8_HUMAN	CCR4-NOT transcription complex, subunit 8	117					negative regulation of cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GATCTCCTTGCTAACTCAGGA	0.418								Direct_reversal_of_damage					22	75					0	0	0	0	T	154250259	T	T	154250259	3	4	179	1	0	0	0	0	1	0	0	0	3640	797	28	4	360	4	CNOT8	5	154250259	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	5504584	154250259	26665001	53	33709											
B4GALT7	11285	broad.mit.edu	37	chr5	177036573	177036573	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggacagggagggaggcctGaacactgtgaagtaccatgt	11	7	16	7	0	0	2	0	2	0	0	0	5	0	5	2	4	2	1	2	4	3	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:177036573G>A	uc003mhy.2	+	6	901	c.861G>A	c.(859-861)CTG>CTA	p.L287L	B4GALT7_uc003mhz.2_Silent_p.L173L	NM_007255	NP_009186	Q9UBV7	B4GT7_HUMAN	xylosylprotein beta 1,4-galactosyltransferase 7	287	Lumenal (Potential).				fibril organization|glycosaminoglycan biosynthetic process|negative regulation of fibroblast proliferation|protein modification process|proteoglycan metabolic process	Golgi cisterna membrane|integral to membrane	metal ion binding|xylosylprotein 4-beta-galactosyltransferase activity			pancreas(1)	1	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGGAGGCCTGAACACTGTGA	0.612													23	125					0	0	0	0	A	177036573	A	A	177036573	2	1	179	1	0	0	0	0	0	0	0	1	1278	1277	45	2		2	B4GALT7	5	177036573	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	22786314	177036573	3878687	54	33710											
TNXB	7148	broad.mit.edu	37	chr6	32020544	32020544	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgggctccaggccccccacGgtgacctcgctctcctcgcc	3	6	10	22	4	1	1	0	1	1	0	5	1	2	1	8	3	0	2	8	3	0	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr6:32020544G>A	uc003nzl.2	-	26	9214	c.9012C>T	c.(9010-9012)ACC>ACT	p.T3004T		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3051	Fibronectin type-III 22.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GGCCCCCCACGGTGACCTCGC	0.682													10	37					0	0	0	0	A	32020544	A	A	32020544	2	1	179	1	0	0	0	0	0	0	0	1	16412	1103	39	1		1	TNXB	6	32020544	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08		32020544	139094523	55	33711											
PRIM2	5558	broad.mit.edu	37	chr6	57398239	57398239	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtatgtcctatttctgaaGggcattggtttaactttgga	9	16	10	6	0	1	1	0	1	1	0	2	2	2	2	1	3	1	3	1	3	4	7			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr6:57398239G>T	uc003pdx.2	+	10	1029	c.942G>T	c.(940-942)AAG>AAT	p.K314N		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	314					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TATTTCTGAAGGGCATTGGTT	0.388													11	104					3.07112e-06	3.30353e-06	1	0	T	57398239	T	T	57398239	3	4	179	1	0	0	0	0	1	0	0	0	12553	991	35	4	976	4	PRIM2	6	57398239	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	25377695	57398239	113716828	56	33712											
BAI3	577	broad.mit.edu	37	chr6	69684692	69684692	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaggattatctgatgtcGatggtgtggaaaagaactcc	11	11	12	7	1	1	3	0	2	1	1	3	6	2	5	2	3	1	0	2	3	4	1	rs139424513		TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr6:69684692G>T	uc003pev.3	+	9	2011	c.1563G>T	c.(1561-1563)TCG>TCT	p.S521S	BAI3_uc010kak.2_Silent_p.S521S	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	521	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ATCTGATGTCGATGGTGTGGA	0.413													3	33					0.004672	0.00479241	1	0	T	69684692	T	T	69684692	2	4	179	1	0	0	0	0	0	0	0	1	1302	1045	37	3		3	BAI3	6	69684692	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	12286453	69684692	101430375	57	33713											
MAP3K7	6885	broad.mit.edu	37	chr6	91226264	91226264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctgacttctgatgacctCtagttgttttttgcattgct	5	19	8	9	0	2	3	0	3	2	0	2	3	2	3	1	0	3	5	1	0	1	7			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr6:91226264C>T	uc003pnz.1	-	17	1939	c.1777G>A	c.(1777-1779)GAG>AAG	p.E593K	MAP3K7_uc003pny.1_Missense_Mutation_p.E130K|MAP3K7_uc003poa.1_3'UTR|MAP3K7_uc003pob.1_Missense_Mutation_p.E566K|MAP3K7_uc003poc.1_3'UTR	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	593					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTGATGACCTCTAGTTGTTTT	0.378													19	95					0	0	0	0	T	91226264	T	T	91226264	3	4	179	1	0	0	0	0	1	0	0	0	9308	922	32	2	47	2	MAP3K7	6	91226264	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	21541572	91226264	79888803	58	33714											
TPD52L1	7164	broad.mit.edu	37	chr6	125569434	125569434	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttttatttctagctacaaGaaaacacatgaaaccctgag	15	12	6	8	0	1	3	0	2	1	1	1	3	1	3	1	0	4	2	1	0	7	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr6:125569434G>A	uc003pzu.1	+	4	510	c.291G>A	c.(289-291)AAG>AAA	p.K97K	TPD52L1_uc003pzv.1_Silent_p.K97K|TPD52L1_uc003pzw.1_Silent_p.K97K|TPD52L1_uc003pzx.1_Silent_p.K68K|TPD52L1_uc003pzy.1_Silent_p.K68K|TPD52L1_uc003pzz.1_Silent_p.K68K	NM_003287	NP_003278	Q16890	TPD53_HUMAN	tumor protein D52-like 1 isoform 1	97					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		CTAGCTACAAGAAAACACATG	0.413													5	17					0	0	0	0	A	125569434	A	A	125569434	2	1	179	1	0	0	0	0	0	0	0	1	16465	933	33	2		2	TPD52L1	6	125569434	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	34343170	125569434	45545633	59	33715											
SCIN	85477	broad.mit.edu	37	chr7	12691524	12691524	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaaaagaatctctgaagtCtggtaagctcaatcgatgga	16	9	10	6	1	3	2	1	1	2	1	5	5	3	3	0	2	1	2	0	2	7	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:12691524C>T	uc003ssn.3	+	15	2228	c.2018C>T	c.(2017-2019)TCT>TTT	p.S673F	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Missense_Mutation_p.S426F	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	673	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TCTCTGAAGTCTGGTAAGCTC	0.338													5	12					0	0	0	0	T	12691524	T	T	12691524	3	4	179	1	0	0	0	0	1	0	0	0	13970	913	32	2	2076	2	SCIN	7	12691524	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08		12691524	146447139	60	33716											
CPVL	54504	broad.mit.edu	37	chr7	29111497	29111497	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aacaagccaatttggtacagGaattctgcatagccccctat	13	10	7	11	0	1	0	0	0	1	0	1	1	1	1	3	2	5	2	3	2	7	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:29111497G>A	uc003szv.2	-	9	875	c.756C>T	c.(754-756)TTC>TTT	p.F252F	CPVL_uc003szw.2_Silent_p.F252F|CPVL_uc003szx.2_Silent_p.F252F	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	252					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						TTTGGTACAGGAATTCTGCAT	0.428													40	63					0	0	0	0	A	29111497	A	A	29111497	2	1	179	1	0	0	0	0	0	0	0	1	3850	1165	41	2		2	CPVL	7	29111497	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	16419973	29111497	130027166	61	33717											
FIGNL1	63979	broad.mit.edu	37	chr7	50514941	50514941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaattgcgaagtaattcttCtgccattcactcaggtgcac	10	13	8	10	1	4	0	2	0	2	0	4	1	4	0	1	1	3	3	1	1	3	6			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:50514941C>G	uc003tpc.2	-	4	422	c.45G>C	c.(43-45)CAG>CAC	p.Q15H	FIGNL1_uc003tpb.2_5'UTR|FIGNL1_uc003tpd.2_Missense_Mutation_p.Q15H|FIGNL1_uc003tpe.2_Missense_Mutation_p.Q15H|FIGNL1_uc010kyy.2_Missense_Mutation_p.Q15H	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	15					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				AGTAATTCTTCTGCCATTCAC	0.413													13	26					0	0	0	0	G	50514941	G	G	50514941	3	3	179	1	0	0	0	0	1	0	0	0	5924	912	32	2	1983	2	FIGNL1	7	50514941	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	21403444	50514941	108623722	62	33718											
HIP1	3092	broad.mit.edu	37	chr7	75192564	75192564	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcggtagaacagatctttCaacctaggggtggagaagga	13	7	15	6	1	2	3	1	0	1	3	2	6	2	4	1	5	3	1	1	5	5	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:75192564C>T	uc003uds.1	-	10	848	c.807G>A	c.(805-807)TTG>TTA	p.L269L	HIP1_uc011kfz.1_Silent_p.L146L	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	269					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						ACAGATCTTTCAACCTAGGGG	0.602			T	PDGFRB	CMML								6	65					0	0	0	0	T	75192564	T	T	75192564	2	4	179	1	0	0	0	0	0	0	0	1	7153	825	29	2		2	HIP1	7	75192564	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	24677623	75192564	83946099	63	33719											
PDK4	5166	broad.mit.edu	37	chr7	95224335	95224335	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatatggttcaccacttacCagcttttaaccaattgcact	12	13	4	12	0	1	0	1	0	0	0	1	0	1	0	3	1	4	3	3	1	5	6			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:95224335C>T	uc003uoa.2	-	2	592	c.272G>A	c.(271-273)TGG>TAG	p.W91*	PDK4_uc003unz.2_5'Flank	NM_002612	NP_002603	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase 4 precursor	91					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity				0	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			CACCACTTACCAGCTTTTAAC	0.388													16	125					0	0	0	0	T	95224335	T	T	95224335	4	4	179	1	0	0	0	0	0	1	0	0	11732	608	21	4	1003	4	PDK4	7	95224335	Nonsense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	20031771	95224335	63914328	64	33720											
FSCN3	29999	broad.mit.edu	37	chr7	127235925	127235925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagaaggaggcatgttatatCcacagggcacgcatctgctc	11	8	12	10	1	1	1	0	0	1	1	3	3	2	2	1	3	1	5	1	3	3	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:127235925C>T	uc003vmd.1	+	2	928	c.709C>T	c.(709-711)CCA>TCA	p.P237S	FSCN3_uc003vmc.1_Missense_Mutation_p.P192S|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_Missense_Mutation_p.P103S|FSCN3_uc010llc.1_Missense_Mutation_p.P237S	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	237						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						CATGTTATATCCACAGGGCAC	0.582													28	87					0	0	0	0	T	127235925	T	T	127235925	3	4	179	1	0	0	0	0	1	0	0	0	6103	855	30	2	715	2	FSCN3	7	127235925	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	32011590	127235925	31902738	65	33721											
MLL3	58508	broad.mit.edu	37	chr7	151859737	151859737	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtgctcactgcaggagtaGaggtagtttctgagatgcct	8	12	14	7	0	2	2	1	1	1	2	2	4	2	3	1	2	3	5	1	2	2	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:151859737G>C	uc003wla.2	-	43	11144	c.10925C>G	c.(10924-10926)TCT>TGT	p.S3642C	MLL3_uc003wkz.2_Missense_Mutation_p.S2703C|MLL3_uc003wky.2_Missense_Mutation_p.S1151C	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3642					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TGCAGGAGTAGAGGTAGTTTC	0.507			N		medulloblastoma								22	75					0	0	0	0	C	151859737	C	C	151859737	3	2	179	1	0	0	0	0	1	0	0	0	9675	942	33	2	3878	2	MLL3	7	151859737	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	24623812	151859737	7278926	66	33722											
MLL3	58508	broad.mit.edu	37	chr7	151859794	151859794	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatatctgaatggggagttGatggagccttggtggattct	8	15	14	4	0	2	2	0	2	2	0	2	5	2	5	1	5	1	1	1	5	3	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:151859794G>C	uc003wla.2	-	43	11087	c.10868C>G	c.(10867-10869)TCA>TGA	p.S3623*	MLL3_uc003wkz.2_Nonsense_Mutation_p.S2684*|MLL3_uc003wky.2_Nonsense_Mutation_p.S1132*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3623					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATGGGGAGTTGATGGAGCCTT	0.373			N		medulloblastoma								12	56					0	0	0	0	C	151859794	C	C	151859794	4	2	179	1	0	0	0	0	0	1	0	0	9675	1294	45	2	3935	2	MLL3	7	151859794	Nonsense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	57	151859794	7278869	67	33723											
DLC1	10395	broad.mit.edu	37	chr8	12957657	12957657	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agttggaaacgctcctctttCgtaccatggggacgttgatg	8	12	12	9	3	1	1	0	1	1	0	3	3	2	3	2	3	2	4	2	3	2	4	rs140340878	byFrequency	TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:12957657C>T	uc003wwm.2	-	9	2633	c.2189G>A	c.(2188-2190)CGA>CAA	p.R730Q	DLC1_uc003wwk.1_Missense_Mutation_p.R293Q|DLC1_uc003wwl.1_Missense_Mutation_p.R327Q|DLC1_uc011kxx.1_Missense_Mutation_p.R219Q	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	730					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GCTCCTCTTTCGTACCATGGG	0.612													6	71					0	0	0	0	T	12957657	T	T	12957657	3	4	179	1	0	0	0	0	1	0	0	0	4572	884	31	1	2437	1	DLC1	8	12957657	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08		12957657	133406365	68	33724											
RUNX1T1	862	broad.mit.edu	37	chr8	93029589	93029589	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggagtgcttctcagtacGatctggaggatgccaccagg	8	10	14	9	1	2	0	1	0	2	0	3	4	2	3	2	4	3	2	2	4	1	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:93029589G>T	uc003yfd.2	-	2	175	c.91C>A	c.(91-93)CGT>AGT	p.R31S	RUNX1T1_uc003yfc.1_Missense_Mutation_p.R4S|RUNX1T1_uc003yfe.1_5'UTR|RUNX1T1_uc010mao.2_Missense_Mutation_p.R4S|RUNX1T1_uc011lgi.1_Missense_Mutation_p.R42S|RUNX1T1_uc003yfh.1_5'UTR|RUNX1T1_uc003yfb.1_5'UTR|RUNX1T1_uc003yff.1_5'UTR|RUNX1T1_uc003yfg.1_5'UTR	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	31		Breakpoint for translocation to form AML1-MTG8 in AML-M2.			generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTCTCAGTACGATCTGGAGGA	0.448													9	66					3.86212e-05	4.08809e-05	1	0	T	93029589	T	T	93029589	3	4	179	1	0	0	0	0	1	0	0	0	13812	1058	37	3	1763	3	RUNX1T1	8	93029589	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	80071932	93029589	53334433	69	33725											
UBR5	51366	broad.mit.edu	37	chr8	103291308	103291308	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaggggatggcttcagccaGaggcacttcaaatggatttg	11	9	13	8	0	2	1	2	0	0	1	2	3	2	3	1	5	1	2	1	5	2	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:103291308G>A	uc003ykr.1	-	43	6163	c.6130C>T	c.(6130-6132)CTG>TTG	p.L2044L	UBR5_uc003yks.1_Silent_p.L2044L	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2044	Pro-rich.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GCTTCAGCCAGAGGCACTTCA	0.433													7	106					0	0	0	0	A	103291308	A	A	103291308	2	1	179	1	0	0	0	0	0	0	0	1	16973	933	33	2		2	UBR5	8	103291308	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	10261719	103291308	43072714	70	33726											
SLC25A32	81034	broad.mit.edu	37	chr8	104417026	104417026	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcttcagcagctgagacaagGtattctgttgcctctaaacg	10	11	10	10	1	3	1	1	1	2	1	3	2	3	1	1	1	4	5	1	1	4	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:104417026G>A	uc003yll.2	-	3	672	c.369C>T	c.(367-369)TAC>TAT	p.Y123Y	SLC25A32_uc011lhr.1_Intron	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	123	Helical; Name=3; (Potential).|Solcar 2.				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	CTGAGACAAGGTATTCTGTTG	0.333													6	52					0	0	0	0	A	104417026	A	A	104417026	2	1	179	1	0	0	0	0	0	0	0	1	14560	1256	44	4		4	SLC25A32	8	104417026	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	1125718	104417026	41946996	71	33727											
OC90	729330	broad.mit.edu	37	chr8	133051056	133051056	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctgggcagaagtgttgtCaagtcttccttgatggttgt	6	15	12	8	0	3	2	1	1	2	1	4	2	4	2	2	2	0	3	2	2	2	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:133051056C>G	uc003ytg.2	-	6	561	c.561G>C	c.(559-561)TTG>TTC	p.L187F	OC90_uc011lix.1_Missense_Mutation_p.L203F	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	203					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GAAGTGTTGTCAAGTCTTCCT	0.527													4	36					0	0	0	0	G	133051056	G	G	133051056	3	3	179	1	0	0	0	0	1	0	0	0	10868	825	29	2	852	2	OC90	8	133051056	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	28634030	133051056	13312966	72	33728											
SLC45A4	57210	broad.mit.edu	37	chr8	142228641	142228641	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggtctcgtcctccttggcGgcttccttgaggaaggtggc	5	11	14	11	2	1	1	0	1	1	0	5	2	4	2	3	6	0	1	3	6	2	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:142228641G>A	uc003ywd.1	-	4	1253	c.945C>T	c.(943-945)GCC>GCT	p.A315A	SLC45A4_uc003ywc.1_Silent_p.A315A|SLC45A4_uc010meq.1_Silent_p.A313A	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	366					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CCTCCTTGGCGGCTTCCTTGA	0.622													22	83					0	0	0	0	A	142228641	A	A	142228641	2	1	179	1	0	0	0	0	0	0	0	1	14707	1103	39	1		1	SLC45A4	8	142228641	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	9177585	142228641	4135381	73	33729											
GSDMD	79792	broad.mit.edu	37	chr8	144644225	144644225	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggagcttttggacagagAgctgtgccagctgctgctgg	7	10	15	9	0	0	1	0	0	0	1	0	4	0	3	1	3	6	5	1	3	0	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:144644225A>T	uc010mfe.2	+	11	1623	c.920A>T	c.(919-921)GAG>GTG	p.E307V	GSDMD_uc003yyf.2_Missense_Mutation_p.E355V|GSDMD_uc003yyg.2_Missense_Mutation_p.E307V|GSDMD_uc003yyh.2_Missense_Mutation_p.E238V	NM_024736	NP_079012	P57764	GSDMD_HUMAN	gasdermin D	307											0						TTGGACAGAGAGCTGTGCCAG	0.677													24	50					0	0	0	0	T	144644225	T	T	144644225	3	4	179	1	0	0	0	0	1	0	0	0	6858	304	11	5	946	5	GSDMD	8	144644225	Missense_Mutation	SNP	A	TCGA-CV-5444-01A-02D-1512-08	2415584	144644225	1719797	74	33730											
RECQL4	9401	broad.mit.edu	37	chr8	145737627	145737627	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatatctggtccttctcctCagcggtcaagtcccccgggc	6	10	9	16	2	4	0	2	0	2	0	7	0	6	0	4	3	1	0	4	3	2	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:145737627C>G	uc003zdj.2	-	19	3168	c.3136G>C	c.(3136-3138)GAG>CAG	p.E1046Q		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	1046					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TCCTTCTCCTCAGCGGTCAAG	0.637			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				10	42					0	0	0	0	G	145737627	G	G	145737627	3	3	179	1	0	0	0	0	1	0	0	0	13267	835	29	2	506	2	RECQL4	8	145737627	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	1093402	145737627	626395	75	33731											
CDKN2A	1029	broad.mit.edu	37	chr9	21970900	21970901	+	Splice_Site	DNP	CC	TT	TT																															tctcagatcatcagtcctcaCctgagggaccttccgcggca																								rs45476696		TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:21970900_21970901CC>TT	uc003zpk.2	-	2	669	c.457_splice	c.e2+1	p.D153_splice	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Splice_Site|CDKN2A_uc010miu.2_Splice_Site|CDKN2A_uc003zpl.2_Splice_Site	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1						cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(22)|p.D153Y(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCAGTCCTCACCTGAGGGACCT	0.599		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	40					0	0	0	0	TT	21970901	TT	TT	21970900	5	4	179	1	0	0	0	0	0	0	1	0	3176	521	18	4	20	4	CDKN2A	9	21970900	Splice_Site	DNP	CC	TCGA-CV-5444-01A-02D-1512-08		21970900	119242531	76	33732											
PRUNE2	158471	broad.mit.edu	37	chr9	79325493	79325493	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggacaaactcctcatcaTgttccacaaggctatctttg	10	13	6	12	0	4	0	2	0	2	0	6	1	6	1	2	2	1	2	2	2	3	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:79325493T>C	uc010mpk.2	-	8	1821	c.1697A>G	c.(1696-1698)CAT>CGT	p.H566R		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	566					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CTCCTCATCATGTTCCACAAG	0.473													23	35					0	0	0	0	C	79325493	C	C	79325493	3	2	179	1	0	0	0	0	1	0	0	0	12703	1464	51	5	7617	5	PRUNE2	9	79325493	Missense_Mutation	SNP	T	TCGA-CV-5444-01A-02D-1512-08	57354593	79325493	61887938	77	33733											
MUSK	4593	broad.mit.edu	37	chr9	113562840	113562840	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttcaccgagatttagccAccaggaactgcctggtgggc	8	10	12	11	1	1	1	1	0	0	1	1	3	1	2	4	3	3	1	4	3	2	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:113562840A>C	uc004bey.2	+	14	2280	c.2182A>C	c.(2182-2184)ACC>CCC	p.T728P	MUSK_uc004bez.1_Missense_Mutation_p.T308P	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	728	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						AGATTTAGCCACCAGGAACTG	0.522													81	323					0	0	0	0	C	113562840	C	C	113562840	3	2	179	1	0	0	0	0	1	0	0	0	10042	159	6	5	2272	5	MUSK	9	113562840	Missense_Mutation	SNP	A	TCGA-CV-5444-01A-02D-1512-08	34237347	113562840	27650591	78	33734											
NR6A1	2649	broad.mit.edu	37	chr9	127289143	127289143	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttgtgatagaggtagatGagccgctcgatcacctccat	11	10	10	10	2	1	4	1	2	0	2	3	5	2	4	3	1	2	2	3	1	3	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:127289143G>A	uc004bor.1	-	8	1294	c.1116C>T	c.(1114-1116)CTC>CTT	p.L372L	NR6A1_uc004boq.1_Silent_p.L367L|NR6A1_uc010mwq.1_Silent_p.L368L	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	372					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						AGAGGTAGATGAGCCGCTCGA	0.493													11	146					0	0	0	0	A	127289143	A	A	127289143	2	1	179	1	0	0	0	0	0	0	0	1	10691	1277	45	2		2	NR6A1	9	127289143	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	13726303	127289143	13924288	79	33735											
ZBTB43	23099	broad.mit.edu	37	chr9	129595320	129595320	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagagatggtgaaaatgaaGaggagagcaccaaagacgag	18	4	15	4	1	0	7	0	3	0	4	0	10	0	7	1	2	1	1	1	2	4	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:129595320G>C	uc004bql.2	+	3	805	c.532G>C	c.(532-534)GAG>CAG	p.E178Q	ZBTB43_uc010mxf.2_Missense_Mutation_p.E178Q	NM_014007	NP_054726	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGAAAATGAAGAGGAGAGCAC	0.532													7	64					0	0	0	0	C	129595320	C	C	129595320	3	2	179	1	0	0	0	0	1	0	0	0	17611	943	33	2	534	2	ZBTB43	9	129595320	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	2306177	129595320	11618111	80	33736											
RALGPS1	9649	broad.mit.edu	37	chr9	129937010	129937010	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcagactgtcgctcagaatcGaaccaggaagcagctctcca	12	7	9	13	2	3	2	2	0	1	2	6	4	3	3	2	1	3	3	2	1	3	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:129937010G>A	uc004bqo.1	+	11	1126	c.859G>A	c.(859-861)GAA>AAA	p.E287K	RALGPS1_uc011mab.1_Missense_Mutation_p.E287K|RALGPS1_uc011mac.1_Missense_Mutation_p.E287K|RALGPS1_uc004bqq.3_Missense_Mutation_p.E287K	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	287	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						GCTCAGAATCGAACCAGGAAG	0.463													14	190					0	0	0	0	A	129937010	A	A	129937010	3	1	179	1	0	0	0	0	1	0	0	0	13082	1059	37	1	897	1	RALGPS1	9	129937010	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	341690	129937010	11276421	81	33737											
FAM73B	84895	broad.mit.edu	37	chr9	131830488	131830488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctctgtaggtggtatgcatGagcttcttcgacatcgtgct	6	14	11	10	2	2	1	0	1	2	0	4	2	2	1	1	2	3	5	1	2	2	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:131830488G>A	uc004bxa.2	+	13	1467	c.1281G>A	c.(1279-1281)ATG>ATA	p.M427I	FAM73B_uc004bwy.2_RNA|FAM73B_uc004bwz.2_RNA|FAM73B_uc011mbn.1_Missense_Mutation_p.M427I|FAM73B_uc004bxb.2_5'Flank	NM_032809	NP_116198	Q7L4E1	FA73B_HUMAN	hypothetical protein LOC84895	427						integral to membrane				skin(1)	1						TGGTATGCATGAGCTTCTTCG	0.647													33	151					0	0	0	0	A	131830488	A	A	131830488	3	1	179	1	0	0	0	0	1	0	0	0	5650	1290	45	2	1327	2	FAM73B	9	131830488	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	1893478	131830488	9382943	82	33738											
BARHL1	56751	broad.mit.edu	37	chr9	135462894	135462894	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggagctcgccgcctcgctCaacctcaccgacacgcaggt	8	6	10	17	5	2	0	2	0	0	0	4	2	2	1	4	2	2	3	4	2	1	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:135462894C>T	uc004cbp.1	+	2	837	c.645C>T	c.(643-645)CTC>CTT	p.L215L		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	215	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		CCGCCTCGCTCAACCTCACCG	0.647													4	22					0	0	0	0	T	135462894	T	T	135462894	2	4	179	1	0	0	0	0	0	0	0	1	1315	813	29	2		2	BARHL1	9	135462894	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	3632406	135462894	5750537	83	33739											
VAV2	7410	broad.mit.edu	37	chr9	136671217	136671217	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actcacctttccttgaaatcGaggaagaccttggccagcgt	10	10	9	12	2	1	2	1	1	0	1	3	4	2	3	4	2	1	0	4	2	2	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:136671217G>A	uc004ces.2	-	9	868	c.822C>T	c.(820-822)CTC>CTT	p.L274L	VAV2_uc004cer.2_Silent_p.L269L	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	274	DH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CCTTGAAATCGAGGAAGACCT	0.587													4	36					0	0	0	0	A	136671217	A	A	136671217	2	1	179	1	0	0	0	0	0	0	0	1	17200	1045	37	1		1	VAV2	9	136671217	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	1208323	136671217	4542214	84	33740											
KIAA1984	84960	broad.mit.edu	37	chr9	139701235	139701235	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggtgctctccaacaccctCgatttgaacagcaagctggc	9	9	10	13	1	1	1	0	1	1	0	3	2	1	1	2	2	5	3	2	2	3	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:139701235C>T	uc004cjf.2	+	12	1353	c.1305C>T	c.(1303-1305)CTC>CTT	p.L435L	C9orf86_uc004cjm.2_5'Flank|C9orf86_uc004cjh.2_5'Flank|C9orf86_uc004cjj.1_5'Flank|C9orf86_uc004cjk.1_5'Flank|C9orf86_uc004cji.1_5'Flank|C9orf86_uc010nbr.1_5'Flank|LOC100131193_uc004cjg.1_Intron	NM_001039374	NP_001034463	Q5T5S1	K1984_HUMAN	hypothetical protein LOC84960	435										ovary(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.33e-06)|Epithelial(140;0.000124)		CCAACACCCTCGATTTGAACA	0.632													4	80					0	0	0	0	T	139701235	T	T	139701235	2	4	179	1	0	0	0	0	0	0	0	1	8305	871	31	1		1	KIAA1984	9	139701235	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	3030018	139701235	1512196	85	33741											
SEC61A2	55176	broad.mit.edu	37	chr10	12197928	12197928	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactaccattaacactggcaGaggtacatcgcacagcgact	13	7	8	13	2	0	1	0	0	0	1	1	2	0	1	1	2	4	3	1	2	3	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr10:12197928G>C	uc001ile.2	+	7	761	c.614G>C	c.(613-615)AGA>ACA	p.R205T	SEC61A2_uc010qbq.1_Missense_Mutation_p.R183T|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Missense_Mutation_p.R205T	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	205	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				AACACTGGCAGAGGTACATCG	0.522													15	83					0	0	0	0	C	12197928	C	C	12197928	3	2	179	1	0	0	0	0	1	0	0	0	14066	942	33	2	640	2	SEC61A2	10	12197928	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08		12197928	123336819	86	33742											
TYSND1	219743	broad.mit.edu	37	chr10	71902546	71902546	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacagccgaaaggatgcctGaggtcaccgagggcccgcaa	11	3	13	14	3	1	1	1	1	0	0	1	4	1	2	5	3	2	1	5	3	2	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr10:71902546G>C	uc001jqr.2	-	3	1515	c.1361C>G	c.(1360-1362)TCA>TGA	p.S454*	TYSND1_uc001jqq.2_RNA|TYSND1_uc001jqs.2_Intron|TYSND1_uc001jqt.2_Intron	NM_173555	NP_775826	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1 isoform a	454	Serine protease.				proteolysis	peroxisome	serine-type endopeptidase activity			large_intestine(1)	1						AAGGATGCCTGAGGTCACCGA	0.642													5	32					0	0	0	0	C	71902546	C	C	71902546	4	2	179	1	0	0	0	0	0	1	0	0	16885	1294	45	2	347	2	TYSND1	10	71902546	Nonsense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	59704618	71902546	63632201	87	33743											
ZNF518A	9849	broad.mit.edu	37	chr10	97920007	97920007	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaaacctgaagatgtccgtGaaacatttggatttagcaga	15	10	9	7	1	0	4	0	2	0	2	1	5	1	5	2	1	3	1	2	1	5	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr10:97920007G>A	uc001klp.2	+	6	4785	c.3928G>A	c.(3928-3930)GAA>AAA	p.E1310K	ZNF518A_uc001klo.1_Missense_Mutation_p.E780K|ZNF518A_uc001klq.2_Missense_Mutation_p.E1310K|ZNF518A_uc001klr.2_Missense_Mutation_p.E1310K	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AGATGTCCGTGAAACATTTGG	0.388													5	48					0	0	0	0	A	97920007	A	A	97920007	3	1	179	1	0	0	0	0	1	0	0	0	18029	1291	45	2	3930	2	ZNF518A	10	97920007	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	26017461	97920007	37614740	88	33744											
ZNF214	7761	broad.mit.edu	37	chr11	7022446	7022446	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaaaccatgtgaaccactCatgtagatttctctaccata	14	12	5	10	0	2	3	1	2	1	1	3	3	2	3	3	0	3	1	3	0	6	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:7022446C>G	uc001mfa.2	-	3	771	c.468G>C	c.(466-468)ATG>ATC	p.M156I	ZNF214_uc010ray.1_Missense_Mutation_p.M156I|ZNF214_uc009yfh.1_Missense_Mutation_p.M156I	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		GTGAACCACTCATGTAGATTT	0.383													35	124					0	0	0	0	G	7022446	G	G	7022446	3	3	179	1	0	0	0	0	1	0	0	0	17837	826	29	2	1356	2	ZNF214	11	7022446	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08		7022446	127984070	89	33745											
TUB	7275	broad.mit.edu	37	chr11	8118955	8118955	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctactttctgcacctggacCgtgaggatgggaagaaggta	10	9	13	9	1	1	2	0	1	1	1	1	5	1	5	3	4	2	2	3	4	4	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:8118955C>T	uc001mga.2	+	7	1017	c.868C>T	c.(868-870)CGT>TGT	p.R290C	TUB_uc010rbk.1_Missense_Mutation_p.R296C|TUB_uc001mfy.2_Missense_Mutation_p.R345C	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	290					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		GCACCTGGACCGTGAGGATGG	0.542													11	92					0	0	0	0	T	8118955	T	T	8118955	3	4	179	1	0	0	0	0	1	0	0	0	16810	652	23	1	1105	1	TUB	11	8118955	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	1096509	8118955	126887561	90	33746											
LDHA	3939	broad.mit.edu	37	chr11	18422455	18422455	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagcaagagggagaaagcCgtcttaatttggtccagcgt	11	9	13	8	2	2	2	1	0	1	2	3	3	3	2	2	2	3	1	2	2	3	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:18422455C>T	uc001mok.3	+	4	588	c.316C>T	c.(316-318)CGT>TGT	p.R106C	LDHA_uc010rdc.1_Intron|LDHA_uc009yhn.2_Missense_Mutation_p.R106C|LDHA_uc009yho.2_5'UTR|LDHA_uc001mol.3_Missense_Mutation_p.R106C|LDHA_uc010rdd.1_Missense_Mutation_p.R135C	NM_005566	NP_005557	P00338	LDHA_HUMAN	lactate dehydrogenase A isoform 1	106		Substrate.			glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)	3					NADH(DB00157)	GGGAGAAAGCCGTCTTAATTT	0.413													4	52					0	0	0	0	T	18422455	T	T	18422455	3	4	179	1	0	0	0	0	1	0	0	0	8738	652	23	1	417	1	LDHA	11	18422455	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	10303500	18422455	116584061	91	33747											
DGKZ	8525	broad.mit.edu	37	chr11	46389294	46389294	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagtactgtgtagccaggatGctggtgagtgctcgtagggg	7	10	17	7	1	0	1	0	1	0	0	1	2	0	2	1	4	4	5	1	4	3	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:46389294G>A	uc001ncn.1	+	4	1055	c.930G>A	c.(928-930)ATG>ATA	p.M310I	DGKZ_uc001nch.1_Missense_Mutation_p.M138I|DGKZ_uc010rgq.1_Missense_Mutation_p.M87I|DGKZ_uc001ncj.1_Missense_Mutation_p.M87I|DGKZ_uc010rgr.1_Missense_Mutation_p.M86I|DGKZ_uc001nck.1_5'UTR|DGKZ_uc001ncl.2_Missense_Mutation_p.M121I|DGKZ_uc001ncm.2_Missense_Mutation_p.M121I|DGKZ_uc009yky.1_Missense_Mutation_p.M121I|DGKZ_uc010rgs.1_Missense_Mutation_p.M121I|DGKZ_uc001nci.1_Missense_Mutation_p.M87I	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	310	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TAGCCAGGATGCTGGTGAGTG	0.642											OREG0020942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	18					0	0	0	0	A	46389294	A	A	46389294	3	1	179	1	0	0	0	0	1	0	0	0	4496	1319	46	4	1384	4	DGKZ	11	46389294	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	27966839	46389294	88617222	92	33748											
DGKZ	8525	broad.mit.edu	37	chr11	46400012	46400012	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtattccgtgcaggtgaaGagctgattgaggctgccaag	10	9	15	7	1	0	4	0	3	0	1	1	4	1	4	2	3	3	4	2	3	3	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:46400012G>T	uc001ncn.1	+	28	3069	c.2944G>T	c.(2944-2946)GAG>TAG	p.E982*	DGKZ_uc001nch.1_Nonsense_Mutation_p.E810*|DGKZ_uc010rgq.1_Nonsense_Mutation_p.E737*|DGKZ_uc001ncj.1_Nonsense_Mutation_p.E760*|DGKZ_uc010rgr.1_Nonsense_Mutation_p.E759*|DGKZ_uc001nck.1_Nonsense_Mutation_p.E572*|DGKZ_uc001ncl.2_Nonsense_Mutation_p.E794*|DGKZ_uc001ncm.2_Nonsense_Mutation_p.E793*|DGKZ_uc009yky.1_Nonsense_Mutation_p.E794*|DGKZ_uc010rgs.1_Nonsense_Mutation_p.E771*|MDK_uc009ykz.1_5'Flank|MDK_uc001nco.2_5'Flank	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	982					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TGCAGGTGAAGAGCTGATTGA	0.622													9	59					3.07112e-06	3.30353e-06	1	0	T	46400012	T	T	46400012	4	4	179	1	0	0	0	0	0	1	0	0	4496	943	33	2	3497	2	DGKZ	11	46400012	Nonsense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	10718	46400012	88606504	93	33749											
DDB2	1643	broad.mit.edu	37	chr11	47256845	47256845	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcagtcccgatggagcccGgctcctgaccacggaccaga	8	7	11	15	3	1	2	1	1	0	1	3	5	3	4	5	3	1	1	5	3	0	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:47256845G>A	uc001neb.2	+	7	1100	c.905G>A	c.(904-906)CGG>CAG	p.R302Q	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Missense_Mutation_p.R238Q|DDB2_uc001ned.2_RNA|DDB2_uc001nee.2_Intron|DDB2_uc001nef.2_Intron|DDB2_uc001neg.2_Missense_Mutation_p.R161Q|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	302	WD 4.				nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						GATGGAGCCCGGCTCCTGACC	0.612			Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				10	131					0	0	0	0	A	47256845	A	A	47256845	3	1	179	1	0	0	0	0	1	0	0	0	4341	1116	39	1	931	1	DDB2	11	47256845	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	856833	47256845	87749671	94	33750											
OR4S1	256148	broad.mit.edu	37	chr11	48328525	48328525	+	Frame_Shift_Del	DEL	C	-	-																															ctgtccttttggttctcatgCcccccatgttcatgtacatt																										TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:48328525delC	uc010rhu.1	+	1	751	c.751delC	c.(751-753)CCCfs	p.P251fs		NM_001004725	NP_001004725	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTTCTCATGCCCCCCATGTT	0.483													---	---	---								-	48328525	-	-	48328525	7	5	179	1	0	1	0	1	0	0	0	0	11136	739	26	0	753	0	OR4S1	11	48328525	Frame_Shift_Del	DEL	C	TCGA-CV-5444-01A-02D-1512-08	1071680	48328525	86677991	95	33751											
PPP2R5B	5526	broad.mit.edu	37	chr11	64698016	64698016	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttcctggttcgcgtcctGatccccctgcactctgtcaa	5	12	8	16	2	2	1	1	1	1	0	6	1	5	1	4	1	1	3	4	1	1	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:64698016G>A	uc001oby.2	+	8	1431	c.846G>A	c.(844-846)CTG>CTA	p.L282L	PPP2R5B_uc001obz.2_Silent_p.L282L	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	282					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						TTCGCGTCCTGATCCCCCTGC	0.612													7	77					0	0	0	0	A	64698016	A	A	64698016	2	1	179	1	0	0	0	0	0	0	0	1	12453	1277	45	2		2	PPP2R5B	11	64698016	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	16369491	64698016	70308500	96	33752											
ARHGEF17	9828	broad.mit.edu	37	chr11	73067756	73067756	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtccctcctgtcccacagctCcaggcccctctgcggcggtt	3	9	10	19	2	1	0	0	0	1	0	5	0	5	0	6	3	2	2	6	3	0	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:73067756C>G	uc001otu.2	+	7	3864	c.3843C>G	c.(3841-3843)CTC>CTG	p.L1281L		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1281					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						TCCCACAGCTCCAGGCCCCTC	0.572													4	60					0	0	0	0	G	73067756	G	G	73067756	2	3	179	1	0	0	0	0	0	0	0	1	900	842	30	2		2	ARHGEF17	11	73067756	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	8369740	73067756	61938760	97	33753											
OR8B4	283162	broad.mit.edu	37	chr11	124294096	124294096	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tctgcagaaggaatacagagGatgttggagagtatcaaagc	15	8	13	5	0	2	3	1	0	1	3	2	6	2	5	0	3	3	3	0	3	5	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:124294096G>C	uc010sak.1	-	1	672	c.672C>G	c.(670-672)ATC>ATG	p.I224M		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GAATACAGAGGATGTTGGAGA	0.458													4	38					0	0	0	0	C	124294096	C	C	124294096	3	2	179	1	0	0	0	0	1	0	0	0	11283	1164	41	2	259	2	OR8B4	11	124294096	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	51226340	124294096	10712420	98	33754											
IGSF9B	22997	broad.mit.edu	37	chr11	133789939	133789939	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atctctgcctgctgcaggagGcccgggcgaggccgggcacg	5	5	17	14	4	1	0	0	0	1	0	2	2	1	1	3	5	3	3	3	5	0	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:133789939G>A	uc001qgx.3	-	18	3912	c.3681C>T	c.(3679-3681)GGC>GGT	p.G1227G		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1227	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GCTGCAGGAGGCCCGGGCGAG	0.687													10	36					0	0	0	0	A	133789939	A	A	133789939	2	1	179	1	0	0	0	0	0	0	0	1	7645	1190	42	4		4	IGSF9B	11	133789939	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	9495843	133789939	1216577	99	33755											
NINJ2	4815	broad.mit.edu	37	chr12	675230	675230	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctccagcaccgccttcaGccgcatggcgttggacatga	7	8	11	15	3	1	1	1	1	0	0	2	2	2	2	4	2	3	4	4	2	0	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:675230G>A	uc001qil.2	-	2	377	c.286C>T	c.(286-288)CTG>TTG	p.L96L	NINJ2_uc010sdr.1_Silent_p.L14L|NINJ2_uc010sds.1_Silent_p.L96L	NM_016533	NP_057617	Q9NZG7	NINJ2_HUMAN	ninjurin 2	50	Extracellular (Potential).				nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				ovary(2)	2	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			ACCGCCTTCAGCCGCATGGCG	0.612													12	43					0	0	0	0	A	675230	A	A	675230	2	1	179	1	0	0	0	0	0	0	0	1	10473	962	34	4		4	NINJ2	12	675230	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08		675230	133176665	100	33756											
CASC1	55259	broad.mit.edu	37	chr12	25272139	25272139	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattacattctcatgaacctCaagtgtgacctctataggtg	11	13	8	9	0	3	2	2	2	2	0	4	3	3	2	2	1	2	0	2	1	5	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:25272139C>G	uc001rgl.2	-	11	1400	c.1318G>C	c.(1318-1320)GAG>CAG	p.E440Q	CASC1_uc001rgk.2_Missense_Mutation_p.E446Q|CASC1_uc001rgm.3_Missense_Mutation_p.E504Q|CASC1_uc001rgj.2_Missense_Mutation_p.E400Q|CASC1_uc010sje.1_Missense_Mutation_p.E381Q|CASC1_uc010sjf.1_Missense_Mutation_p.E328Q|CASC1_uc010sjg.1_Missense_Mutation_p.E440Q	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	440										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TCATGAACCTCAAGTGTGACC	0.373													5	68					0	0	0	0	G	25272139	G	G	25272139	3	3	179	1	0	0	0	0	1	0	0	0	2672	835	29	2	852	2	CASC1	12	25272139	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	24596909	25272139	108579756	101	33757											
LRRK2	120892	broad.mit.edu	37	chr12	40745387	40745387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attagtctgtctgacgagacGcattttattacctaaaaacg	13	13	7	8	3	2	2	0	1	2	1	2	3	2	2	1	0	2	1	1	0	6	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:40745387G>A	uc001rmg.3	+	44	6549	c.6428G>A	c.(6427-6429)CGC>CAC	p.R2143H	LRRK2_uc009zjw.2_Missense_Mutation_p.R981H|LRRK2_uc001rmi.2_Missense_Mutation_p.R976H	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2143			R -> H (in PARK8).		activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTGACGAGACGCATTTTATTA	0.398													13	53					0	0	0	0	A	40745387	A	A	40745387	3	1	179	1	0	0	0	0	1	0	0	0	9083	1087	38	1	6602	1	LRRK2	12	40745387	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	15473248	40745387	93106508	102	33758											
KRT4	3851	broad.mit.edu	37	chr12	53207700	53207700	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggttgtagaggcttctgctgCcaaatcccccagaagagcat	10	9	11	11	0	1	3	0	0	1	3	2	3	2	3	3	2	3	5	3	2	3	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:53207700C>T	uc001saz.2	-	1	636	c.365G>A	c.(364-366)GGC>GAC	p.G122D		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	48						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						GCTTCTGCTGCCAAATCCCCC	0.587													35	103					0	0	0	0	T	53207700	T	T	53207700	3	4	179	1	0	0	0	0	1	0	0	0	8516	739	26	4	1455	4	KRT4	12	53207700	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	12462313	53207700	80644195	103	33759											
USP15	9958	broad.mit.edu	37	chr12	62715321	62715321	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agattgtggaacaaatacatGagtaacacatttgaaccact	17	10	7	7	0	0	3	0	2	0	1	0	4	0	4	1	1	4	1	1	1	5	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:62715321G>C	uc001src.1	+	5	561	c.552G>C	c.(550-552)ATG>ATC	p.M184I	USP15_uc001srb.1_Missense_Mutation_p.M184I|USP15_uc001sra.2_Missense_Mutation_p.M184I	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	184					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		ACAAATACATGAGTAACACAT	0.328													6	42					0	0	0	0	C	62715321	C	C	62715321	3	2	179	1	0	0	0	0	1	0	0	0	17114	1290	45	2	570	2	USP15	12	62715321	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	9507621	62715321	71136574	104	33760											
NAV3	89795	broad.mit.edu	37	chr12	78224975	78224976	+	5'Flank	INS	-	AG	AG																															agagagagagagagagagacINSagagagagagagagagagag																								rs77759134	by1000genomes	TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:78224975_78224976insAG	uc001syp.2	+						NAV3_uc001syo.2_5'Flank	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3							nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						gagagagagacagagagagaga	0.208										HNSCC(70;0.22)			---	---	---								AG	78224976	AG	AG	78224975	6	5	179	0	1	1	1	0	0	0	0	0	10238	493	17	0		0	NAV3	12	78224975	5'Flank	INS	-	TCGA-CV-5444-01A-02D-1512-08	15509654	78224975	55626920	105	33761											
MLXIP	22877	broad.mit.edu	37	chr12	122622100	122622100	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctccccagaacaactgctCagggaaatccgaccccaaaa	15	5	6	15	1	2	1	1	0	1	1	4	3	3	2	5	1	3	1	5	1	5	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:122622100C>G	uc001ubq.2	+	12	2117	c.2117C>G	c.(2116-2118)TCA>TGA	p.S706*	MLXIP_uc001ubt.2_Nonsense_Mutation_p.S313*	NM_014938	NP_055753	Q9HAP2	MLXIP_HUMAN	MLX interacting protein	706					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			ovary(2)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		AACAACTGCTCAGGGAAATCC	0.567													13	136					0	0	0	0	G	122622100	G	G	122622100	4	3	179	1	0	0	0	0	0	1	0	0	9689	838	29	2	2163	2	MLXIP	12	122622100	Nonsense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	44397125	122622100	11229795	106	33762											
GPR109B	8843	broad.mit.edu	37	chr12	123200775	123200775	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacacatttgcagtgccattCtggatcagcaacttcttctt	9	14	6	12	0	4	0	1	0	3	0	4	1	4	1	1	1	4	2	1	1	1	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:123200775C>G	uc001ucy.3	-	1	665	c.510G>C	c.(508-510)CAG>CAC	p.Q170H	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	170	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	CAGTGCCATTCTGGATCAGCA	0.522													12	70					0	0	0	0	G	123200775	G	G	123200775	3	3	179	1	0	0	0	0	1	0	0	0	6664	912	32	2	657	2	GPR109B	12	123200775	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	578675	123200775	10651120	107	33763											
RNF17	56163	broad.mit.edu	37	chr13	25376549	25376549	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gggaagaggaagctaaagtgGaatttttgaaaatggtaaat	17	10	13	1	0	0	2	0	1	0	1	0	5	0	5	0	4	1	2	0	4	9	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr13:25376549G>C	uc001upr.2	+	14	1830	c.1789G>C	c.(1789-1791)GAA>CAA	p.E597Q	RNF17_uc010tdd.1_Missense_Mutation_p.E456Q|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.E597Q|RNF17_uc001ups.2_Missense_Mutation_p.E536Q	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	597					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AGCTAAAGTGGAATTTTTGAA	0.333													6	65					0	0	0	0	C	25376549	C	C	25376549	3	2	179	1	0	0	0	0	1	0	0	0	13526	1175	41	2	1843	2	RNF17	13	25376549	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08		25376549	89793329	108	33764											
FREM2	341640	broad.mit.edu	37	chr13	39266631	39266631	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacctggacaaaggcaaccAcagcatcactcagttcacac	15	5	6	15	0	3	0	3	0	0	0	3	1	3	1	2	2	3	3	2	2	3	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr13:39266631A>T	uc001uwv.2	+	1	5459	c.5150A>T	c.(5149-5151)CAC>CTC	p.H1717L		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1717	Extracellular (Potential).|CSPG 12.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AAAGGCAACCACAGCATCACT	0.428													8	91					0	0	0	0	T	39266631	T	T	39266631	3	4	179	1	0	0	0	0	1	0	0	0	6079	159	6	5	5152	5	FREM2	13	39266631	Missense_Mutation	SNP	A	TCGA-CV-5444-01A-02D-1512-08	13890082	39266631	75903247	109	33765											
FREM2	341640	broad.mit.edu	37	chr13	39430346	39430346	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgagagagatgagagaggccTtcactgttcacctaaaacct	13	9	10	9	0	2	4	2	2	0	3	2	7	2	4	3	1	1	1	3	1	2	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr13:39430346T>A	uc001uwv.2	+	12	7318	c.7009T>A	c.(7009-7011)TTC>ATC	p.F2337I	FREM2_uc001uww.2_Missense_Mutation_p.F423I	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2337	Extracellular (Potential).|Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GAGAGAGGCCTTCACTGTTCA	0.403													7	66					0	0	0	0	A	39430346	A	A	39430346	3	1	179	1	0	0	0	0	1	0	0	0	6079	1609	56	5	7055	5	FREM2	13	39430346	Missense_Mutation	SNP	T	TCGA-CV-5444-01A-02D-1512-08	163715	39430346	75739532	110	33766											
FOXO1	2308	broad.mit.edu	37	chr13	41134162	41134162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttctggcccagaacccggCtgttgggctgggctacccca	5	8	13	15	2	1	1	0	0	1	1	1	1	1	1	4	4	2	5	4	4	2	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr13:41134162C>T	uc001uxl.3	-	2	1851	c.1466G>A	c.(1465-1467)AGC>AAC	p.S489N	FOXO1_uc010acc.1_Missense_Mutation_p.S304N	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	489					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		CAGAACCCGGCTGTTGGGCTG	0.522													12	79					0	0	0	0	T	41134162	T	T	41134162	3	4	179	1	0	0	0	0	1	0	0	0	6057	797	28	4	505	4	FOXO1	13	41134162	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	1703816	41134162	74035716	111	33767											
ANKRD10	55608	broad.mit.edu	37	chr13	111558412	111558412	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccattcgccacaagggcactGatgcattctaggctcccaga	10	8	9	14	1	1	2	0	1	1	1	3	2	2	2	3	2	1	3	3	2	2	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr13:111558412G>A	uc001vrn.2	-	3	558	c.423C>T	c.(421-423)ATC>ATT	p.I141I	ANKRD10_uc001vro.1_Silent_p.I141I|ANKRD10_uc001vrp.1_Silent_p.I141I	NM_017664	NP_060134	Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	141	ANK 4.									central_nervous_system(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			CAAGGGCACTGATGCATTCTA	0.433													3	14					0	0	0	0	A	111558412	A	A	111558412	2	1	179	1	0	0	0	0	0	0	0	1	638	1280	45	2		2	ANKRD10	13	111558412	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	70424250	111558412	3611466	112	33768											
TINF2	26277	broad.mit.edu	37	chr14	24711353	24711353	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttgctccaataccttggcCtttaggcccatacaaaggcg	10	10	8	13	1	0	0	0	0	0	0	1	0	1	0	4	3	3	1	4	3	5	6			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:24711353C>T	uc001woa.3	-	1	528	c.186G>A	c.(184-186)AAG>AAA	p.K62K	TINF2_uc010alm.2_5'Flank|TINF2_uc001wob.3_Silent_p.K62K|TINF2_uc010tof.1_Silent_p.K62K|TINF2_uc001woc.3_Silent_p.K62K	NM_001099274	NP_001092744	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	62					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|protein binding|telomeric DNA binding				0				GBM - Glioblastoma multiforme(265;0.0185)		ATACCTTGGCCTTTAGGCCCA	0.562									Ataxia_Pancytopenia_syndrome|Congenital_Dyskeratosis		OREG0022621	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	88					0	0	0	0	T	24711353	T	T	24711353	2	4	179	1	0	0	0	0	0	0	0	1	15989	680	24	4		4	TINF2	14	24711353	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08		24711353	82638187	113	33769											
FOXG1	2290	broad.mit.edu	37	chr14	29237058	29237058	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctacaacgcgctcatcatGatggccatccggcagagccc	10	6	10	15	3	2	2	2	1	0	1	3	2	3	2	3	2	4	3	3	2	2	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:29237058G>C	uc001wqe.2	+	1	772	c.573G>C	c.(571-573)ATG>ATC	p.M191I		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	191	Fork-head.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CGCTCATCATGATGGCCATCC	0.418													4	40					0	0	0	0	C	29237058	C	C	29237058	3	2	179	1	0	0	0	0	1	0	0	0	6041	1290	45	2	575	2	FOXG1	14	29237058	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	4525705	29237058	78112482	114	33770											
SMOC1	64093	broad.mit.edu	37	chr14	70418890	70418890	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgtgacccacagtgcaacctCcactgctccaggactcaacc	10	6	7	18	1	1	1	1	1	0	0	3	2	3	2	5	1	4	2	5	1	2	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:70418890C>G	uc001xls.1	+	2	388	c.135C>G	c.(133-135)CTC>CTG	p.L45L	SMOC1_uc001xlt.1_Silent_p.L45L	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	45	Kazal-like.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		AGTGCAACCTCCACTGCTCCA	0.522													26	94					0	0	0	0	G	70418890	G	G	70418890	2	3	179	1	0	0	0	0	0	0	0	1	14865	842	30	2		2	SMOC1	14	70418890	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	41181832	70418890	36930650	115	33771											
ZFYVE1	53349	broad.mit.edu	37	chr14	73448574	73448574	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcgccatctggtcatcgggGatctcaccgctgaagcggtc	6	9	13	13	4	3	1	2	1	2	0	6	2	3	2	2	4	2	1	2	4	1	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:73448574G>A	uc001xnm.2	-	5	1873	c.1233C>T	c.(1231-1233)ATC>ATT	p.I411I	ZFYVE1_uc001xnl.2_5'UTR|ZFYVE1_uc010arj.2_Silent_p.I411I	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	411						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		GGTCATCGGGGATCTCACCGC	0.577													5	79					0	0	0	0	A	73448574	A	A	73448574	2	1	179	1	0	0	0	0	0	0	0	1	17730	1164	41	2		2	ZFYVE1	14	73448574	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	3029684	73448574	33900966	116	33772											
C14orf45	80127	broad.mit.edu	37	chr14	74523883	74523883	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caagataaaatcttcatcacCcagcaaattgcaatatcaga	18	9	4	10	0	4	2	3	0	1	2	4	2	4	2	1	0	2	2	1	0	6	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:74523883C>T	uc010tup.1	+	11	1623	c.1500C>T	c.(1498-1500)ACC>ACT	p.T500T	C14orf45_uc001xpm.1_RNA	NM_025057	NP_079333	Q8ND07	CN045_HUMAN	hypothetical protein LOC80127	500											0				BRCA - Breast invasive adenocarcinoma(234;0.00351)		TCTTCATCACCCAGCAAATTG	0.393													15	81					0	0	0	0	T	74523883	T	T	74523883	2	4	179	1	0	0	0	0	0	0	0	1	1781	610	22	4		4	C14orf45	14	74523883	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	1075309	74523883	32825657	117	33773											
TRIP11	9321	broad.mit.edu	37	chr14	92471271	92471271	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcactaatctttccgtttCagctttagataaatcatgct	10	18	4	9	1	4	1	3	0	1	1	5	1	5	1	1	0	2	3	1	0	4	7			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:92471271C>T	uc001xzy.2	-	11	3837	c.3049G>A	c.(3049-3051)GAA>AAA	p.E1017K	TRIP11_uc010auf.1_Missense_Mutation_p.E753K	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1017	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CTTTCCGTTTCAGCTTTAGAT	0.303			T	PDGFRB	AML								6	63					0	0	0	0	T	92471271	T	T	92471271	3	4	179	1	0	0	0	0	1	0	0	0	16622	835	29	2	2934	2	TRIP11	14	92471271	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	17947388	92471271	14878269	118	33774											
DICER1	23405	broad.mit.edu	37	chr14	95562276	95562276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaaaccccgatataaggtGattcagtgttttatctgcat	11	15	7	8	1	3	1	2	1	1	0	3	2	3	1	2	1	2	2	2	1	4	6			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:95562276G>A	uc001ydw.2	-	24	5163	c.4981C>T	c.(4981-4983)CAC>TAC	p.H1661Y	DICER1_uc010avh.1_Missense_Mutation_p.H559Y|DICER1_uc001ydv.2_Missense_Mutation_p.H1651Y|DICER1_uc001ydx.2_Missense_Mutation_p.H1661Y|DICER1_uc001ydy.1_Missense_Mutation_p.H513Y	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1661					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GATATAAGGTGATTCAGTGTT	0.378			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				20	126					0	0	0	0	A	95562276	A	A	95562276	3	1	179	1	0	0	0	0	1	0	0	0	4543	1290	45	2	807	2	DICER1	14	95562276	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	3091005	95562276	11787264	119	33775											
DYNC1H1	1778	broad.mit.edu	37	chr14	102508999	102508999	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaatctgctccgtgcgggcCgcatctttgtgttcgagcca	5	12	12	12	4	2	1	0	1	2	0	4	2	3	1	3	1	3	3	3	1	1	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:102508999C>T	uc001yks.2	+	69	12591	c.12427C>T	c.(12427-12429)CGC>TGC	p.R4143C		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4143	AAA 6 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CCGTGCGGGCCGCATCTTTGT	0.582													7	63					0	0	0	0	T	102508999	T	T	102508999	3	4	179	1	0	0	0	0	1	0	0	0	4863	652	23	1	12701	1	DYNC1H1	14	102508999	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	6946723	102508999	4840541	120	33776											
AHNAK2	113146	broad.mit.edu	37	chr14	105412495	105412495	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacctccacgtcgggggccGtcacgtccgtcttcgggcct	4	8	12	17	6	2	0	1	0	1	0	6	0	4	0	5	3	0	0	5	3	0	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:105412495G>A	uc010axc.1	-	7	9413	c.9293C>T	c.(9292-9294)ACG>ATG	p.T3098M	AHNAK2_uc001ypx.2_Missense_Mutation_p.T2998M	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3098						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTCGGGGGCCGTCACGTCCGT	0.627													39	236					0	0	0	0	A	105412495	A	A	105412495	3	1	179	1	0	0	0	0	1	0	0	0	415	1145	40	1	8098	1	AHNAK2	14	105412495	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	2903496	105412495	1937045	121	33777											
PLA2G4F	255189	broad.mit.edu	37	chr15	42442333	42442333	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttcatgctcagagccacctCctggccctgaaagacacagc	10	7	8	16	0	2	3	2	1	0	2	3	3	3	3	4	1	3	1	4	1	1	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr15:42442333C>G	uc001zoz.2	-	10	955	c.892G>C	c.(892-894)GAG>CAG	p.E298Q	PLA2G4F_uc001zoy.2_5'Flank|PLA2G4F_uc010bcr.2_Missense_Mutation_p.E49Q|PLA2G4F_uc001zpa.2_Missense_Mutation_p.E49Q|PLA2G4F_uc010bcs.2_Missense_Mutation_p.E85Q	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	298					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		AGAGCCACCTCCTGGCCCTGA	0.617													3	37					0	0	0	0	G	42442333	G	G	42442333	3	3	179	1	0	0	0	0	1	0	0	0	12061	864	30	2	1701	2	PLA2G4F	15	42442333	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08		42442333	60089059	122	33778											
TP53BP1	7158	broad.mit.edu	37	chr15	43730581	43730581	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcttgcctggcttcacaGatacagctcaacacagacat	11	11	6	13	0	3	2	2	0	1	2	4	2	3	2	1	1	4	2	1	1	2	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr15:43730581G>C	uc001zrs.2	-	16	3265	c.3117C>G	c.(3115-3117)ATC>ATG	p.I1039M	TP53BP1_uc010udp.1_Missense_Mutation_p.I1039M|TP53BP1_uc001zrq.3_Missense_Mutation_p.I1044M|TP53BP1_uc001zrr.3_Missense_Mutation_p.I1044M|TP53BP1_uc010udq.1_Missense_Mutation_p.I1044M	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1039					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TGGCTTCACAGATACAGCTCA	0.398								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					15	71					0	0	0	0	C	43730581	C	C	43730581	3	2	179	1	0	0	0	0	1	0	0	0	16450	932	33	2	2853	2	TP53BP1	15	43730581	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	1288248	43730581	58800811	123	33779											
NEO1	4756	broad.mit.edu	37	chr15	73581580	73581580	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgactcccagccaccccagcGtaagtagaagcatctctttt	10	10	7	14	1	1	2	0	1	1	1	3	2	2	2	4	0	3	3	4	0	3	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr15:73581580G>A	uc002avm.3	+	25	3884	c.3742_splice	c.e25+1	p.P1248_splice	NEO1_uc010ukx.1_Splice_Site_p.P1237_splice|NEO1_uc010uky.1_Splice_Site_p.Q1248_splice|NEO1_uc010ukz.1_Splice_Site_p.P661_splice|NEO1_uc002avn.3_Splice_Site_p.P886_splice	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor						axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						CCACCCCAGCGTAAGTAGAAG	0.458													4	27					0	0	0	0	A	73581580	A	A	73581580	5	1	179	1	0	0	0	0	0	0	1	0	10390	1159	40	1	3841	1	NEO1	15	73581580	Splice_Site	SNP	G	TCGA-CV-5444-01A-02D-1512-08	29850999	73581580	28949812	124	33780											
SYNM	23336	broad.mit.edu	37	chr15	99672808	99672808	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacagaaacggaaacctctGaacacattgccatccgtgga	14	7	8	12	2	1	2	0	1	1	1	2	4	2	4	3	2	5	0	3	2	4	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr15:99672808G>A	uc002bup.2	+	6	4363	c.4243G>A	c.(4243-4245)GAA>AAA	p.E1415K	SYNM_uc002buo.2_Intron|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	1415	Tail.|Interaction with DMD and UTRN.|Interaction with TLN1 and VCL.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						GGAAACCTCTGAACACATTGC	0.527													29	249					0	0	0	0	A	99672808	A	A	99672808	3	1	179	1	0	0	0	0	1	0	0	0	15521	1291	45	2	4256	2	SYNM	15	99672808	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	26091228	99672808	2858584	125	33781											
PRSS36	146547	broad.mit.edu	37	chr16	31151714	31151714	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagattcgttgtgtcaagatGgagacagcagcagccacagg	12	7	13	9	1	1	3	1	0	0	3	2	4	1	3	1	2	3	3	1	2	1	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr16:31151714G>A	uc002ebd.2	-	14	2249	c.2190C>T	c.(2188-2190)TCC>TCT	p.S730S	PRSS36_uc010vff.1_Silent_p.S505S|PRSS36_uc010vfg.1_Silent_p.S725S|PRSS36_uc010vfh.1_Intron	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	730	Peptidase S1 3.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						GTGTCAAGATGGAGACAGCAG	0.592													6	63					0	0	0	0	A	31151714	A	A	31151714	2	1	179	1	0	0	0	0	0	0	0	1	12687	1335	47	4		4	PRSS36	16	31151714	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08		31151714	59203039	126	33782											
PYDC1	260434	broad.mit.edu	37	chr16	31228221	31228221	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgatatctagctgcccgagCgcgccccgcgggatgcgctc	6	6	13	16	7	1	0	0	0	1	0	2	3	1	1	3	1	4	2	3	1	2	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr16:31228221C>T	uc002ebo.2	-	1	178	c.129G>A	c.(127-129)GCG>GCA	p.A43A	TRIM72_uc002ebn.1_Intron	NM_152901	NP_690865	Q8WXC3	PYDC1_HUMAN	pyrin domain containing 1	43	DAPIN.				innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|positive regulation of interleukin-1 beta secretion|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex|nucleus	cysteine-type endopeptidase activity|protein binding				0						GCTGCCCGAGCGCGCCCCGCG	0.647													5	64					0	0	0	0	T	31228221	T	T	31228221	2	4	179	1	0	0	0	0	0	0	0	1	12923	755	27	1		1	PYDC1	16	31228221	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	76507	31228221	59126532	127	33783											
NKD1	85407	broad.mit.edu	37	chr16	50667326	50667326	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcactttgtgaggtccccCaaggcccagggcaagagtgt	10	7	13	11	0	0	2	0	1	0	1	1	2	1	2	3	3	1	2	3	3	3	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr16:50667326C>A	uc002egg.1	+	10	1271	c.1047C>A	c.(1045-1047)CCC>CCA	p.P349P		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	349					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		TGAGGTCCCCCAAGGCCCAGG	0.667													6	59					5.18039e-06	5.54246e-06	1	0	A	50667326	A	A	50667326	2	1	179	1	0	0	0	0	0	0	0	1	10495	581	21	4		4	NKD1	16	50667326	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	19439105	50667326	39687427	128	33784											
NUTF2	10204	broad.mit.edu	37	chr16	67899106	67899106	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actaccagttatttgataatGatagaacccaactaggcgca	15	10	7	9	1	0	3	0	2	0	1	0	3	0	3	2	1	3	2	2	1	7	6			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr16:67899106G>C	uc002eup.2	+	2	172	c.73G>C	c.(73-75)GAT>CAT	p.D25H	NUTF2_uc010vkf.1_Missense_Mutation_p.D25H	NM_005796	NP_005787	P61970	NTF2_HUMAN	nuclear transport factor 2	25	NTF2.				protein transport	cytosol|nuclear pore	protein binding|transporter activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00443)|Epithelial(162;0.0199)|all cancers(182;0.129)		ATTTGATAATGATAGAACCCA	0.483													5	36					0	0	0	0	C	67899106	C	C	67899106	3	2	179	1	0	0	0	0	1	0	0	0	10833	1290	45	2	75	2	NUTF2	16	67899106	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	17231780	67899106	22455647	129	33785											
AP1G1	164	broad.mit.edu	37	chr16	71768545	71768545	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaactttaatgacttgtgtGatggtccccgtgttaaatgc	10	14	10	7	1	0	3	0	2	0	1	1	3	1	3	2	1	2	1	2	1	4	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr16:71768545G>C	uc010cgg.2	-	22	2648	c.2334C>G	c.(2332-2334)ATC>ATG	p.I778M	AP1G1_uc002fba.2_Missense_Mutation_p.I781M|AP1G1_uc002fbb.2_Missense_Mutation_p.I801M|AP1G1_uc002faz.2_Missense_Mutation_p.I195M	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	778	GAE.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				TGACTTGTGTGATGGTCCCCG	0.453													13	193					0	0	0	0	C	71768545	C	C	71768545	3	2	179	1	0	0	0	0	1	0	0	0	732	1280	45	2	142	2	AP1G1	16	71768545	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	3869439	71768545	18586208	130	33786											
SMG6	23293	broad.mit.edu	37	chr17	1972199	1972199	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttcgagctccatctgcctCatctgactgtggtcctccag	6	13	8	14	1	3	1	1	1	2	0	7	2	6	1	4	1	2	1	4	1	0	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:1972199C>T	uc002fub.1	-	16	3763	c.3708G>A	c.(3706-3708)ATG>ATA	p.M1236I	SMG6_uc010vqv.1_Missense_Mutation_p.M328I	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	1236	Potential.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						CCATCTGCCTCATCTGACTGT	0.592													5	21					0	0	0	0	T	1972199	T	T	1972199	3	4	179	1	0	0	0	0	1	0	0	0	14861	826	29	2	567	2	SMG6	17	1972199	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08		1972199	79223011	131	33787											
TP53	7157	broad.mit.edu	37	chr17	7578506	7578514	+	In_Frame_Del	DEL	GGCAGGTCT	-	-																															atcaacccacagctgcacagGgcaggtcttggccagttggc																										TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:7578506_7578514delGGCAGGTCT	uc002gim.2	-	5	610_618	c.416_424delAGACCTGCC	c.(415-426)AAGACCTGCCCT>ACT	p.139_142KTCP>T	TP53_uc002gig.1_In_Frame_Del_p.139_142KTCP>T|TP53_uc002gih.2_In_Frame_Del_p.139_142KTCP>T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.7_10KTCP>T|TP53_uc010cng.1_In_Frame_Del_p.7_10KTCP>T|TP53_uc002gii.1_In_Frame_Del_p.7_10KTCP>T|TP53_uc010cnh.1_In_Frame_Del_p.139_142KTCP>T|TP53_uc010cni.1_In_Frame_Del_p.139_142KTCP>T|TP53_uc002gij.2_In_Frame_Del_p.139_142KTCP>T|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_In_Frame_Del_p.46_49KTCP>T|TP53_uc002gio.2_In_Frame_Del_p.7_10KTCP>T|TP53_uc010vug.1_In_Frame_Del_p.100_103KTCP>T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	139_142	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> R (in a sporadic cancer; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C141Y(61)|p.T140I(12)|p.C141*(11)|p.C141R(10)|p.C141W(10)|p.K139N(8)|p.K139K(7)|p.0?(7)|p.T140T(6)|p.K139fs*31(4)|p.C141C(4)|p.C141F(4)|p.K139fs*9(3)|p.C141fs*29(3)|p.K139Q(2)|p.K139R(2)|p.K139E(2)|p.P142F(2)|p.P142A(2)|p.P142T(2)|p.P142S(2)|p.N131fs*27(2)|p.C141S(2)|p.P142fs*28(2)|p.C141fs*8(2)|p.K139*(2)|p.K139T(1)|p.L137_W146del10(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.F134_T140>S(1)|p.T140fs*9(1)|p.C141fs*34(1)|p.C141fs*30(1)|p.A138_V143delAKTCPV(1)|p.T140N(1)|p.K139fs*11(1)|p.K139fs*10(1)|p.T140fs*30(1)|p.A138_P142delAKTCP(1)|p.C135_T140delCQLAKT(1)|p.Q136_K139delQLAK(1)|p.C141A(1)|p.C141G(1)|p.C141_P142insXX(1)|p.K139_C141>N(1)|p.K139fs*29(1)|p.C141fs*5(1)|p.P142del(1)|p.P142fs*7(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGCTGCACAGGGCAGGTCTTGGCCAGTTG	0.569		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578514	-	-	7578506	7	5	179	1	0	1	0	1	0	0	0	0	16448	1232	43	0	874	0	TP53	17	7578506	In_Frame_Del	DEL	GGCAGGTCT	TCGA-CV-5444-01A-02D-1512-08	5606307	7578506	73616704	132	33788											
TP53	7157	broad.mit.edu	37	chr17	7579912	7579912	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgactgcggctcctccaTggcagtgacccggaaggcag	8	7	13	13	2	1	2	0	2	1	0	3	3	3	3	3	4	1	3	3	4	1	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:7579912T>C	uc002gim.2	-	2	195	c.1A>G	c.(1-3)ATG>GTG	p.M1V	TP53_uc002gig.1_Missense_Mutation_p.M1V|TP53_uc002gih.2_Missense_Mutation_p.M1V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.M1V|TP53_uc010cni.1_Missense_Mutation_p.M1V|TP53_uc002gij.2_Missense_Mutation_p.M1V|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Missense_Mutation_p.M1V|TP53_uc002gio.2_Intron|TP53_uc010vug.1_5'UTR|TP53_uc010cnk.1_Missense_Mutation_p.M16V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	1	Transcription activation (acidic).|Interaction with HRMT1L2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCTCCTCCATGGCAGTGACC	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	18					0	0	0	0	C	7579912	C	C	7579912	3	2	179	1	0	0	0	0	1	0	0	0	16448	1464	51	5	1309	5	TP53	17	7579912	Missense_Mutation	SNP	T	TCGA-CV-5444-01A-02D-1512-08	1406	7579912	73615298	133	33789											
DNAH2	146754	broad.mit.edu	37	chr17	7734557	7734557	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagatcactgaggcacaaacCctctttgatactttgctttc	10	13	6	12	0	2	3	1	2	1	1	3	3	2	3	1	1	3	2	1	1	2	4			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:7734557C>A	uc002giu.1	+	79	12398	c.12384C>A	c.(12382-12384)ACC>ACA	p.T4128T	DNAH2_uc010cnm.1_Silent_p.T1066T	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4128	TPR 5.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGGCACAAACCCTCTTTGATA	0.557													54	118					4.37618e-36	4.97635e-36	1	0	A	7734557	A	A	7734557	2	1	179	1	0	0	0	0	0	0	0	1	4624	610	22	4		4	DNAH2	17	7734557	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	154645	7734557	73460653	134	33790											
MYH13	8735	broad.mit.edu	37	chr17	10248844	10248844	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtactgcctgggctgcttGgtgtccagctgctggttgat	5	13	14	9	0	0	1	0	1	0	0	1	1	1	1	2	3	5	6	2	3	2	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:10248844G>T	uc002gmk.1	-	14	1443	c.1353C>A	c.(1351-1353)ACC>ACA	p.T451T	MYH13_uc010vvf.1_Silent_p.T126T	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	451	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGGGCTGCTTGGTGTCCAGCT	0.512													24	88					1.74807e-11	1.94338e-11	1	0	T	10248844	T	T	10248844	2	4	179	1	0	0	0	0	0	0	0	1	10085	1335	47	4		4	MYH13	17	10248844	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	2514287	10248844	70946366	135	33791											
NCOR1	9611	broad.mit.edu	37	chr17	15971267	15971267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcgtgggcaggtggctcCgataaacctcgcctgcagtg	7	8	15	11	3	0	0	0	0	0	0	2	1	1	0	3	3	3	3	3	3	2	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:15971267C>T	uc002gpo.2	-	32	4922	c.4682G>A	c.(4681-4683)CGG>CAG	p.R1561Q	NCOR1_uc002gpn.2_Missense_Mutation_p.R1577Q|NCOR1_uc002gpm.2_Missense_Mutation_p.R82Q|NCOR1_uc010vwb.1_Missense_Mutation_p.R145Q|NCOR1_uc010coy.2_Missense_Mutation_p.R469Q|NCOR1_uc010vwc.1_Missense_Mutation_p.R372Q	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1561	Interaction with ETO.|Interaction with C1D (By similarity).			R -> W (in Ref. 1; AAC33550).	cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAGGTGGCTCCGATAAACCTC	0.512													18	23					0	0	0	0	T	15971267	T	T	15971267	3	4	179	1	0	0	0	0	1	0	0	0	10289	652	23	1	2700	1	NCOR1	17	15971267	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	5722423	15971267	65223943	136	33792											
AOC3	8639	broad.mit.edu	37	chr17	41003847	41003847	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtggagcgtcatggaggcCccctgccctatcaccgacgc	6	7	12	16	3	2	0	2	0	0	0	2	3	2	2	4	3	2	0	4	3	1	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:41003847C>T	uc002ibv.2	+	1	647	c.487C>T	c.(487-489)CCC>TCC	p.P163S		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	163	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	TCATGGAGGCCCCCTGCCCTA	0.617													11	37					0	0	0	0	T	41003847	T	T	41003847	3	4	179	1	0	0	0	0	1	0	0	0	728	623	22	4	489	4	AOC3	17	41003847	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	25032580	41003847	40191363	137	33793											
HDAC5	10014	broad.mit.edu	37	chr17	42155928	42155928	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cggcccccaccgacagcaagGccatggcgctcacagtctcg	8	4	11	18	4	2	0	1	0	1	0	3	1	2	0	4	3	1	2	4	3	1	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:42155928G>A	uc002ifd.1	-	26	3480	c.3269C>T	c.(3268-3270)GCC>GTC	p.A1090V	HDAC5_uc002ife.1_Missense_Mutation_p.A1090V|HDAC5_uc002iff.1_Missense_Mutation_p.A1091V|HDAC5_uc010czp.1_Missense_Mutation_p.A1005V	NM_005474	NP_005465	Q9UQL6	HDAC5_HUMAN	histone deacetylase 5 isoform 1	1090	Nuclear export signal.				B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			ovary(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		CGACAGCAAGGCCATGGCGCT	0.692													16	143					0	0	0	0	A	42155928	A	A	42155928	3	1	179	1	0	0	0	0	1	0	0	0	7049	1203	42	4	107	4	HDAC5	17	42155928	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	1152081	42155928	39039282	138	33794											
KIF18B	146909	broad.mit.edu	37	chr17	43009571	43009571	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagctctggggtgcagggCtggctgggagggtggggtgg	3	7	26	5	0	1	0	0	0	1	0	1	2	1	2	0	10	2	4	0	10	0	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:43009571C>A	uc010wji.1	-	10	1379	c.1278G>T	c.(1276-1278)CAG>CAT	p.Q426H	KIF18B_uc002iht.2_Missense_Mutation_p.Q426H|KIF18B_uc010wjh.1_Missense_Mutation_p.Q414H	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				GGGTGCAGGGCTGGCTGGGAG	0.657													3	17					0.00024832	0.000261459	1	0	A	43009571	A	A	43009571	3	1	179	1	0	0	0	0	1	0	0	0	8320	796	28	4	1316	4	KIF18B	17	43009571	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	853643	43009571	38185639	139	33795											
LRRC37A	9884	broad.mit.edu	37	chr17	44408471	44408471	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gacagatcgaaagacttaacCcacgctatttccattttaga	14	11	6	10	2	0	3	0	0	0	3	2	5	1	3	2	0	1	1	2	0	4	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:44408471C>A	uc002ikg.2	+	9	3831	c.3828C>A	c.(3826-3828)ACC>ACA	p.T1276T	ARL17A_uc002iki.3_Intron|ARL17A_uc002ikh.3_Intron|ARL17B_uc002ikf.2_Intron|LRRC37A_uc002ikj.2_Silent_p.T237T|LRRC37A_uc010daw.1_Silent_p.T206T	NM_014834	NP_055649	A6NMS7	L37A1_HUMAN	leucine rich repeat containing 37A precursor	1276	Extracellular (Potential).					integral to membrane					0		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		AAGACTTAACCCACGCTATTT	0.458													23	69					0.000295444	0.000309438	1	0	A	44408471	A	A	44408471	2	1	179	1	0	0	0	0	0	0	0	1	9041	610	22	4		4	LRRC37A	17	44408471	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	1398900	44408471	36786739	140	33796											
COIL	8161	broad.mit.edu	37	chr17	55038285	55038285	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgacgactcggcatctgttCaagtcgaccagaagccagaa	12	7	11	11	3	2	3	1	1	1	2	4	5	2	3	2	1	1	2	2	1	3	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:55038285C>G	uc002iuu.2	-	1	127	c.96G>C	c.(94-96)TTG>TTC	p.L32F		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	32						Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)					GGCATCTGTTCAAGTCGACCA	0.587											OREG0024594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	33					0	0	0	0	G	55038285	G	G	55038285	3	3	179	1	0	0	0	0	1	0	0	0	3680	825	29	2	1662	2	COIL	17	55038285	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	10629814	55038285	26156925	141	33797											
C17orf70	80233	broad.mit.edu	37	chr17	79517287	79517287	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcataccttcatgcgtcctGggagacgcggacagcgagac	9	7	12	13	4	2	2	2	0	0	2	3	5	3	3	2	2	3	0	2	2	1	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:79517287G>T	uc002kaq.2	-	3	1288	c.1233C>A	c.(1231-1233)CCC>CCA	p.P411P	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Silent_p.P260P	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	411					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CATGCGTCCTGGGAGACGCGG	0.607													27	101					1.7367e-05	1.84814e-05	1	0	T	79517287	T	T	79517287	2	4	179	1	0	0	0	0	0	0	0	1	1884	1335	47	4		4	C17orf70	17	79517287	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	24479002	79517287	1677923	142	33798											
TSPAN10	83882	broad.mit.edu	37	chr17	79612251	79612251	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacttccccttctccctgctGgggctgctggccctggccat	3	11	10	17	0	1	0	0	0	1	0	3	0	2	0	5	4	3	3	5	4	1	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:79612251G>A	uc010die.2	+	2	360	c.270G>A	c.(268-270)CTG>CTA	p.L90L	TSPAN10_uc002kaw.1_Silent_p.L90L|TSPAN10_uc010did.1_RNA	NM_031945	NP_114151	Q9H1Z9	TSN10_HUMAN	tetraspanin 10	90	Helical; (Potential).					integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TCTCCCTGCTGGGGCTGCTGG	0.662													19	73					0	0	0	0	A	79612251	A	A	79612251	2	1	179	1	0	0	0	0	0	0	0	1	16701	1335	47	4		4	TSPAN10	17	79612251	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08	94964	79612251	1582959	143	33799											
ZNF750	79755	broad.mit.edu	37	chr17	80788944	80788944	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcctgggcaggtaggcattCtgtgcttttcttaacaggcc	7	12	12	10	0	2	0	0	0	2	0	2	0	2	0	2	4	3	4	2	4	2	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:80788944C>G	uc002kga.2	-	2	1698	c.1387G>C	c.(1387-1389)GAA>CAA	p.E463Q	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	463						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GGTAGGCATTCTGTGCTTTTC	0.522													29	216					0	0	0	0	G	80788944	G	G	80788944	3	3	179	1	0	0	0	0	1	0	0	0	18199	922	32	2	792	2	ZNF750	17	80788944	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	1176693	80788944	406266	144	33800											
KDM4B	23030	broad.mit.edu	37	chr19	5047507	5047507	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacgtggcccagtggaacatCgggagcctccggaccatcct	8	6	13	14	3	0	0	0	0	0	0	3	4	2	3	5	4	2	0	5	4	1	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:5047507C>T	uc002mbq.3	+	6	679	c.453C>T	c.(451-453)ATC>ATT	p.I151I	KDM4B_uc010xil.1_Silent_p.I151I|KDM4B_uc010xim.1_Silent_p.I151I	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	151	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						AGTGGAACATCGGGAGCCTCC	0.662													5	59					0	0	0	0	T	5047507	T	T	5047507	2	4	179	1	0	0	0	0	0	0	0	1	8168	874	31	1		1	KDM4B	19	5047507	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08		5047507	54081476	145	33801											
ZNF358	140467	broad.mit.edu	37	chr19	7584186	7584186	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggcctgagacccgtttatGaagagctcgactctgactcc	10	9	10	12	2	1	4	0	3	1	2	3	6	2	4	3	1	1	2	3	1	3	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:7584186G>A	uc002mgn.2	+	2	228	c.58G>A	c.(58-60)GAA>AAA	p.E20K		NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	20					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						ACCCGTTTATGAAGAGCTCGA	0.577													10	109					0	0	0	0	A	7584186	A	A	7584186	3	1	179	1	0	0	0	0	1	0	0	0	17934	1291	45	2	60	2	ZNF358	19	7584186	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	2536679	7584186	51544797	146	33802											
ZNF615	284370	broad.mit.edu	37	chr19	52506950	52506950	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaacaaaccaaaagtcacCtgggcctgcatcattgtctc	14	9	6	12	0	3	0	2	0	1	0	4	0	3	0	3	1	3	1	3	1	5	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:52506950C>T	uc002pye.1	-	3	307	c.15G>A	c.(13-15)CAG>CAA	p.Q5Q	ZNF615_uc002pyf.1_Silent_p.Q5Q|ZNF615_uc002pyg.1_5'UTR|ZNF615_uc002pyh.1_Silent_p.Q5Q|ZNF615_uc010epi.1_Intron|ZNF615_uc010ydg.1_Intron	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CAAAAGTCACCTGGGCCTGCA	0.333													6	49					0	0	0	0	T	52506950	T	T	52506950	2	4	179	1	0	0	0	0	0	0	0	1	18107	695	24	4		4	ZNF615	19	52506950	Silent	SNP	C	TCGA-CV-5444-01A-02D-1512-08	44922764	52506950	6622033	147	33803											
CNOT3	4849	broad.mit.edu	37	chr19	54656252	54656252	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaacataccgctgtcgctggGtgtctgtccactgggccctg	5	10	13	13	2	1	0	0	0	1	0	3	1	2	0	3	2	2	2	3	2	2	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:54656252G>T	uc002qdj.1	+	15	2104	c.1793G>T	c.(1792-1794)GGT>GTT	p.G598V	CNOT3_uc010yel.1_Missense_Mutation_p.G598V|CNOT3_uc002qdi.2_Missense_Mutation_p.G511V|CNOT3_uc002qdk.1_Missense_Mutation_p.G598V|CNOT3_uc010ere.1_RNA|CNOT3_uc002qdl.2_Missense_Mutation_p.G53V	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	598	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CTGTCGCTGGGTGTCTGTCCA	0.632													8	83					3.09899e-07	3.38845e-07	1	0	T	54656252	T	T	54656252	3	4	179	1	0	0	0	0	1	0	0	0	3635	1261	44	4	1847	4	CNOT3	19	54656252	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	2149302	54656252	4472731	148	33804											
ZNF418	147686	broad.mit.edu	37	chr19	58438294	58438294	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtctttctccagtgtgacCtcgctgatggttcctaaggt	6	14	11	10	1	2	2	0	2	2	0	5	2	3	2	3	3	0	2	3	3	1	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:58438294C>A	uc002qqs.1	-	4	1547	c.1255G>T	c.(1255-1257)GGT>TGT	p.G419C	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.G334C	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	419	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CCAGTGTGACCTCGCTGATGG	0.463													31	151					6.00712e-18	6.75377e-18	1	0	A	58438294	A	A	58438294	3	1	179	1	0	0	0	0	1	0	0	0	17962	681	24	4	779	4	ZNF418	19	58438294	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	3782042	58438294	690689	149	33805											
C19orf18	147685	broad.mit.edu	37	chr19	58472888	58472888	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcttataaagtgactcgaGctgttgtctttcctcagcct	7	16	8	10	1	3	1	1	1	2	0	5	2	4	1	2	0	2	3	2	0	3	5			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:58472888G>A	uc002qqv.2	-	5	507	c.403C>T	c.(403-405)CTC>TTC	p.L135F		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	135	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		AGTGACTCGAGCTGTTGTCTT	0.443													14	86					0	0	0	0	A	58472888	A	A	58472888	3	1	179	1	0	0	0	0	1	0	0	0	1919	971	34	4	252	4	C19orf18	19	58472888	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	34594	58472888	656095	150	33806											
C20orf117	140710	broad.mit.edu	37	chr20	35443718	35443718	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcaccaggatggcatggatGagcttggtgtccctggggcc	6	8	16	11	1	0	1	0	1	0	0	1	3	1	3	3	6	1	3	3	6	0	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr20:35443718G>C	uc002xgd.1	-	5	1740	c.1413C>G	c.(1411-1413)CTC>CTG	p.L471L	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	471											0		Myeloproliferative disorder(115;0.00874)				TGGCATGGATGAGCTTGGTGT	0.637													24	46					0	0	0	0	C	35443718	C	C	35443718	2	2	179	1	0	0	0	0	0	0	0	1	2093	1277	45	2		2	C20orf117	20	35443718	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08		35443718	27581802	151	33807											
CSTF1	1477	broad.mit.edu	37	chr20	54972832	54972832	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcctggcttctggttcaaggGattatactcttaaattattt	9	18	7	7	0	3	0	1	0	2	0	4	1	4	1	1	3	1	2	1	3	6	7			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr20:54972832G>A	uc002xxl.1	+	4	780	c.580G>A	c.(580-582)GAT>AAT	p.D194N	CSTF1_uc002xxm.1_Missense_Mutation_p.D194N|CSTF1_uc002xxn.1_Missense_Mutation_p.D194N|CSTF1_uc002xxo.1_Missense_Mutation_p.D137N	NM_001033521	NP_001028693	Q05048	CSTF1_HUMAN	cleavage stimulation factor subunit 1	194	WD 2.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(1)	1			Colorectal(105;0.202)			TGGTTCAAGGGATTATACTCT	0.393													7	54					0	0	0	0	A	54972832	A	A	54972832	3	1	179	1	0	0	0	0	1	0	0	0	4000	1174	41	2	590	2	CSTF1	20	54972832	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08	19529114	54972832	8052688	152	33808											
LAMA5	3911	broad.mit.edu	37	chr20	60888187	60888187	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccgctgtaggacacgagcCgcagctcctgctcgaagcgc	7	5	12	17	5	0	0	0	0	0	0	2	3	1	1	4	1	4	5	4	1	2	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr20:60888187C>T	uc002ycq.2	-	65	8979	c.8912G>A	c.(8911-8913)CGG>CAG	p.R2971Q		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2971	Laminin G-like 2.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGACACGAGCCGCAGCTCCTG	0.652													14	7					0	0	0	0	T	60888187	T	T	60888187	3	4	179	1	0	0	0	0	1	0	0	0	8649	652	23	1	2239	1	LAMA5	20	60888187	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	5915355	60888187	2137333	153	33809											
CABLES2	81928	broad.mit.edu	37	chr20	60966046	60966046	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctagaactgctgggtgaggCgcctgtaatgaggtaacact	10	9	14	8	1	0	3	0	2	0	1	0	3	0	3	1	3	3	4	1	3	4	3			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr20:60966046C>T	uc002ycv.2	-	10	1425	c.1418G>A	c.(1417-1419)CGC>CAC	p.R473H		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	473					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			CTGGGTGAGGCGCCTGTAATG	0.612													24	71					0	0	0	0	T	60966046	T	T	60966046	3	4	179	1	0	0	0	0	1	0	0	0	2542	768	27	1	22	1	CABLES2	20	60966046	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	77859	60966046	2059474	154	33810											
CRKL	1399	broad.mit.edu	37	chr22	21304053	21304053	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taaatggccagtgggaaggcGaagtgaacgggcgcaaaggg	13	4	18	6	3	0	1	0	1	0	0	0	3	0	2	1	5	1	1	1	5	6	1			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr22:21304053G>A	uc002ztf.2	+	3	1341	c.832G>A	c.(832-834)GAA>AAA	p.E278K	CRKL_uc002ztg.1_RNA	NM_005207	NP_005198	P46109	CRKL_HUMAN	v-crk sarcoma virus CT10 oncogene homolog	278	SH3 2.				JNK cascade|Ras protein signal transduction	cytosol	protein tyrosine kinase activity|SH3/SH2 adaptor activity|signal transducer activity				0	all_cancers(11;1.16e-25)|all_epithelial(7;3.37e-24)|Lung NSC(8;7.25e-16)|all_lung(8;1.37e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.176)			GTGGGAAGGCGAAGTGAACGG	0.453													18	218					0	0	0	0	A	21304053	A	A	21304053	3	1	179	1	0	0	0	0	1	0	0	0	3900	1059	37	1	842	1	CRKL	22	21304053	Missense_Mutation	SNP	G	TCGA-CV-5444-01A-02D-1512-08		21304053	30000513	155	33811											
TOP3B	8940	broad.mit.edu	37	chr22	22313587	22313587	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caggggcgagaaagacacctCcatcaactcatccatgcctg	12	6	9	14	1	2	2	2	0	0	2	4	3	4	2	4	2	2	0	4	2	2	0			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr22:22313587C>G	uc002zvs.2	-	16	2257	c.1822G>C	c.(1822-1824)GAG>CAG	p.E608Q	TOP3B_uc010gtm.1_Missense_Mutation_p.E153Q|TOP3B_uc002zvr.2_Missense_Mutation_p.E333Q|TOP3B_uc010gtl.2_Missense_Mutation_p.E608Q|TOP3B_uc002zvt.3_Missense_Mutation_p.E608Q	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	608					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		AAAGACACCTCCATCAACTCA	0.602													6	83					0	0	0	0	G	22313587	G	G	22313587	3	3	179	1	0	0	0	0	1	0	0	0	16435	864	30	2	778	2	TOP3B	22	22313587	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	1009534	22313587	28990979	156	33812											
MYO18B	84700	broad.mit.edu	37	chr22	26228956	26228956	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggctgttgtggatcaaaatCcctctcaggtaacacagggc	10	10	11	10	0	2	0	2	0	1	0	4	1	3	1	1	4	1	3	1	4	3	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr22:26228956C>A	uc003abz.1	+	16	3302	c.3052C>A	c.(3052-3054)CCC>ACC	p.P1018T	MYO18B_uc003aca.1_Missense_Mutation_p.P899T|MYO18B_uc010guy.1_Missense_Mutation_p.P899T|MYO18B_uc010guz.1_Missense_Mutation_p.P899T|MYO18B_uc011aka.1_Missense_Mutation_p.P172T|MYO18B_uc011akb.1_Missense_Mutation_p.P531T	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1018	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGATCAAAATCCCTCTCAGGT	0.488													10	51					1.58986e-06	1.72887e-06	1	0	A	26228956	A	A	26228956	3	1	179	1	0	0	0	0	1	0	0	0	10119	855	30	2	3110	2	MYO18B	22	26228956	Missense_Mutation	SNP	C	TCGA-CV-5444-01A-02D-1512-08	3915369	26228956	25075610	157	33813											
PHEX	5251	broad.mit.edu	37	chrX	22095598	22095598	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atctgctccctttcagaagcGattgaaaaagcagatgccaa	14	9	8	10	1	2	3	1	1	1	2	3	4	3	3	2	0	4	2	2	0	4	2			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chrX:22095598G>A	uc004dah.2	+	5	644	c.441G>A	c.(439-441)GCG>GCA	p.A147A	PHEX_uc011mjr.1_Silent_p.A147A|PHEX_uc011mjs.1_Silent_p.A50A	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	147	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						TTTCAGAAGCGATTGAAAAAG	0.438													25	59					0	0	0	0	A	22095598	A	A	22095598	2	1	179	1	0	0	0	0	0	0	0	1	11874	1045	37	1		1	PHEX	23	22095598	Silent	SNP	G	TCGA-CV-5444-01A-02D-1512-08		22095598	133174962	158	33814											
MTOR	2475	broad.mit.edu	37	chr1	11297982	11297982	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacagtgcagatggccagcTcccggatctcaaacacctgg	10	6	10	15	1	1	1	1	0	1	1	3	2	2	2	4	3	3	2	4	3	1	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr1:11297982T>C	uc001asd.2	-	13	2247	c.2126A>G	c.(2125-2127)GAG>GGG	p.E709G		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	709					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						GATGGCCAGCTCCCGGATCTC	0.582													12	33					0	0	0	0	C	11297982	C	C	11297982	3	2	180	1	0	0	0	0	1	0	0	0	10007	1551	54	5	5707	5	MTOR	1	11297982	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08		11297982	237952639	1	33815											
PRAMEF16	654348	broad.mit.edu	37	chr1	13497673	13497673	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caagcctcagtcagctaaagGagctgcatctgattcatatc	12	10	8	11	0	4	1	3	1	1	0	5	2	4	2	1	1	4	3	1	1	4	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr1:13497673G>C	uc001aux.2	+	3	1000	c.970G>C	c.(970-972)GAG>CAG	p.E324Q		NM_001045480	NP_001038945	Q5VWM1	PRA16_HUMAN	PRAME family member 16	324	LRR 1.										0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAGCTAAAGGAGCTGCATCT	0.473													10	93					0	0	0	0	C	13497673	C	C	13497673	3	2	180	1	0	0	0	0	1	0	0	0	12491	1175	41	2	980	2	PRAMEF16	1	13497673	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	2199691	13497673	235752948	2	33816											
PQLC2	54896	broad.mit.edu	37	chr1	19653876	19653876	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctgccctggcttgtgggCagcctgggcgtgctgctgct	2	10	15	14	1	0	0	0	0	0	0	0	0	0	0	3	3	5	5	3	3	0	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr1:19653876C>T	uc001bby.2	+	8	1126	c.774C>T	c.(772-774)GGC>GGT	p.G258G	PQLC2_uc001bbz.2_Silent_p.G193G|PQLC2_uc001bca.2_Silent_p.G258G|PQLC2_uc001bcb.2_Silent_p.G147G|PQLC2_uc001bcc.2_Silent_p.G147G	NM_017765	NP_060235	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2 isoform 1	258	Helical; (Potential).					integral to membrane					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGCTTGTGGGCAGCCTGGGCG	0.652													8	32					0	0	0	0	T	19653876	T	T	19653876	2	4	180	1	0	0	0	0	0	0	0	1	12479	697	25	4		4	PQLC2	1	19653876	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08	6156203	19653876	229596745	3	33817											
RABGGTB	5876	broad.mit.edu	37	chr1	76255009	76255009	+	Frame_Shift_Del	DEL	C	-	-																															gtgctagtatcggacatgatCctcatcttttatacactctt																										TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr1:76255009delC	uc001dgy.1	+	3	348	c.277delC	c.(277-279)CCTfs	p.P93fs	RABGGTB_uc009wbt.1_RNA|RABGGTB_uc001dha.1_Frame_Shift_Del_p.P47fs|SNORD45B_uc009wbv.1_5'Flank	NM_004582	NP_004573	P53611	PGTB2_HUMAN	RAB geranylgeranyltransferase, beta subunit	93	PFTB 2.				protein modification process|visual perception		metal ion binding|protein binding|Rab geranylgeranyltransferase activity			ovary(1)	1						CGGACATGATCCTCATCTTTT	0.368													---	---	---								-	76255009	-	-	76255009	7	5	180	1	0	1	0	1	0	0	0	0	13033	855	30	0	287	0	RABGGTB	1	76255009	Frame_Shift_Del	DEL	C	TCGA-CV-5966-01A-11D-1683-08	56601133	76255009	172995612	4	33818											
DCST2	127579	broad.mit.edu	37	chr1	155006045	155006045	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgtggccttccaccagtaGctccagaagcccgtaggccg	7	7	12	15	2	0	1	0	0	0	1	2	1	2	1	6	2	2	4	6	2	3	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr1:155006045G>T	uc001fgm.2	-	1	213	c.133C>A	c.(133-135)CTA>ATA	p.L45I	DCST2_uc009wpb.2_RNA|DCST1_uc010per.1_5'Flank|DCST1_uc001fgn.1_5'Flank|DCST1_uc010pes.1_5'Flank	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	45	Helical; (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TCCACCAGTAGCTCCAGAAGC	0.632													14	69					1.5739e-10	1.69981e-10	1	0	T	155006045	T	T	155006045	3	4	180	1	0	0	0	0	1	0	0	0	4320	962	34	4	2248	4	DCST2	1	155006045	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	78751036	155006045	94244576	5	33819											
GON4L	54856	broad.mit.edu	37	chr1	155736338	155736338	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcagtttcaggactacacCcttaggcaatagcagtgggt	10	11	10	10	0	2	0	2	0	0	0	2	1	2	1	1	3	2	3	1	3	4	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr1:155736338C>T	uc001flz.2	-	21	3023	c.2926G>A	c.(2926-2928)GGT>AGT	p.G976S	GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Missense_Mutation_p.G976S|GON4L_uc009wrh.1_Missense_Mutation_p.G976S|GON4L_uc001fma.1_Missense_Mutation_p.G976S|GON4L_uc001fmb.3_Missense_Mutation_p.G172S|GON4L_uc001fmc.2_Missense_Mutation_p.G976S|GON4L_uc001fmd.3_Missense_Mutation_p.G976S|GON4L_uc009wri.2_Missense_Mutation_p.G562S	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	976					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					AGGACTACACCCTTAGGCAAT	0.498													19	66					0	0	0	0	T	155736338	T	T	155736338	3	4	180	1	0	0	0	0	1	0	0	0	6609	623	22	4	3961	4	GON4L	1	155736338	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	730293	155736338	93514283	6	33820											
ARHGEF11	9826	broad.mit.edu	37	chr1	156926233	156926233	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcttggtcttagggaagaaCggtagccacttgtccttgtc	7	14	11	9	1	2	1	0	0	2	1	4	2	3	2	2	3	2	1	2	3	4	6			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr1:156926233C>T	uc001fqo.2	-	18	2570	c.1530G>A	c.(1528-1530)CCG>CCA	p.P510P	ARHGEF11_uc001fqn.2_Silent_p.P550P|ARHGEF11_uc001fqp.1_Silent_p.P39P	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	510					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TAGGGAAGAACGGTAGCCACT	0.338													21	86					0	0	0	0	T	156926233	T	T	156926233	2	4	180	1	0	0	0	0	0	0	0	1	896	523	19	1		1	ARHGEF11	1	156926233	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08	1189895	156926233	92324388	7	33821											
CD1E	913	broad.mit.edu	37	chr1	158326543	158326543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ataagaacattctttctcccCacacacccagccctgtcttt	10	12	3	16	0	3	1	0	0	3	1	4	1	3	1	4	0	2	0	4	0	2	4			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr1:158326543C>T	uc001fse.2	+	6	1263	c.1024C>T	c.(1024-1026)CAC>TAC	p.H342Y	CD1E_uc001fsd.2_3'UTR|CD1E_uc001fsk.2_Missense_Mutation_p.H252Y|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Missense_Mutation_p.H153Y|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Missense_Mutation_p.H98Y|CD1E_uc001fsf.2_Intron|CD1E_uc001fry.2_Intron|CD1E_uc001fsg.2_3'UTR|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Intron|CD1E_uc009wsv.2_Missense_Mutation_p.H243Y|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_Intron	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	342					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					TCTTTCTCCCCACACACCCAG	0.343													9	50					0	0	0	0	T	158326543	T	T	158326543	3	4	180	1	0	0	0	0	1	0	0	0	2993	594	21	4	1046	4	CD1E	1	158326543	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	1400310	158326543	90924078	8	33822											
IL24	11009	broad.mit.edu	37	chr1	207072852	207072852	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagccttctgggctgtgaaaGacactatggtgagtaaagtg	12	10	13	6	0	1	3	0	2	1	1	1	3	1	3	1	2	1	2	1	2	5	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr1:207072852G>A	uc001hes.1	+	3	506	c.232G>A	c.(232-234)GAC>AAC	p.D78N	IL24_uc001het.1_Intron|IL24_uc001heu.1_Missense_Mutation_p.D79N|IL24_uc001hev.1_Intron|IL24_uc001hew.1_Missense_Mutation_p.D79N|IL24_uc001hex.1_Intron	NM_006850	NP_006841	Q13007	IL24_HUMAN	interleukin 24 isoform 1 precursor	78					apoptosis	extracellular space	cytokine activity				0	Breast(84;0.201)					GGCTGTGAAAGACACTATGGT	0.547													15	56					0	0	0	0	A	207072852	A	A	207072852	3	1	180	1	0	0	0	0	1	0	0	0	7716	942	33	2	241	2	IL24	1	207072852	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	48746309	207072852	42177769	9	33823											
KCNF1	3754	broad.mit.edu	37	chr2	11053801	11053801	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaggtactacaacaagcagCgcgtcctggagaccgcggcc	10	5	12	14	4	1	1	1	0	0	1	2	2	2	1	3	3	5	2	3	3	4	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr2:11053801C>T	uc002rax.2	+	1	1739	c.1249C>T	c.(1249-1251)CGC>TGC	p.R417C		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	417	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CAACAAGCAGCGCGTCCTGGA	0.617													6	20					0	0	0	0	T	11053801	T	T	11053801	3	4	180	1	0	0	0	0	1	0	0	0	8065	768	27	1	1251	1	KCNF1	2	11053801	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08		11053801	232145572	10	33824											
FAM161A	84140	broad.mit.edu	37	chr2	62067206	62067206	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagcttctttgcttttctcCttcagagaccttctccgttc	5	17	6	13	1	4	2	1	0	3	2	7	3	4	2	3	0	2	3	3	0	0	7			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr2:62067206C>A	uc010ypo.1	-	3	1035	c.933G>T	c.(931-933)AAG>AAT	p.K311N	FAM161A_uc002sbm.3_Missense_Mutation_p.K311N|FAM161A_uc002sbn.3_Missense_Mutation_p.K121N|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Missense_Mutation_p.K202N	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	311	Potential.				response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						TGCTTTTCTCCTTCAGAGACC	0.443													17	132					4.96729e-08	5.25948e-08	1	0	A	62067206	A	A	62067206	3	1	180	1	0	0	0	0	1	0	0	0	5500	680	24	4	1065	4	FAM161A	2	62067206	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	51013405	62067206	181132167	11	33825											
DLX1	1745	broad.mit.edu	37	chr2	172951395	172951395	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctccaggggcggactcggaGaagagcacggtggtggaagg	9	4	19	9	3	0	2	0	0	0	2	2	5	1	4	2	8	1	1	2	8	2	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr2:172951395G>A	uc002uhl.2	+	2	525	c.327G>A	c.(325-327)GAG>GAA	p.E109E	DLX1_uc010fqj.1_Silent_p.E109E|DLX1_uc002uhm.2_Intron	NM_178120	NP_835221	P56177	DLX1_HUMAN	distal-less homeobox 1 isoform 1	109						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CGGACTCGGAGAAGAGCACGG	0.567													21	90					0	0	0	0	A	172951395	A	A	172951395	2	1	180	1	0	0	0	0	0	0	0	1	4592	933	33	2		2	DLX1	2	172951395	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08	110884189	172951395	70247978	12	33826											
CASP8	841	broad.mit.edu	37	chr2	202131498	202131498	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagacaccaggcagggctCaaatttctgcctacaggtgg	10	9	11	11	0	3	1	2	0	1	1	3	1	3	1	2	4	2	2	2	4	2	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr2:202131498C>T	uc002uxr.1	+	3	498	c.289C>T	c.(289-291)CAA>TAA	p.Q97*	CASP8_uc010ftc.1_Nonsense_Mutation_p.Q97*|CASP8_uc002uxo.1_Nonsense_Mutation_p.Q97*|CASP8_uc002uxp.1_Nonsense_Mutation_p.Q97*|CASP8_uc002uxq.1_Nonsense_Mutation_p.Q97*|CASP8_uc002uxs.1_Nonsense_Mutation_p.Q97*|CASP8_uc002uxt.1_Nonsense_Mutation_p.Q156*|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Nonsense_Mutation_p.Q97*|CASP8_uc002uxw.1_Nonsense_Mutation_p.Q97*|CASP8_uc002uxy.1_Nonsense_Mutation_p.Q97*|CASP8_uc002uxx.1_Nonsense_Mutation_p.Q97*|CASP8_uc010ftf.2_Nonsense_Mutation_p.Q97*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	97					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						AGGCAGGGCTCAAATTTCTGC	0.488										HNSCC(4;0.00038)			5	18					0	0	0	0	T	202131498	T	T	202131498	4	4	180	1	0	0	0	0	0	1	0	0	2689	827	29	2	472	2	CASP8	2	202131498	Nonsense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	29180103	202131498	41067875	13	33827											
OR6B2	389090	broad.mit.edu	37	chr2	240969562	240969562	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagagctgcgtcatgcacccGacgaaagagatgcgtttctg	10	9	12	10	4	2	2	1	0	1	2	2	5	2	2	1	0	4	3	1	0	2	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr2:240969562G>T	uc002vyr.2	-	2	331	c.285C>A	c.(283-285)GTC>GTA	p.V95V	OR6B2_uc010zoc.1_Silent_p.V95V	NM_001005853	NP_001005853	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		TCATGCACCCGACGAAAGAGA	0.577													8	46					1.76689e-08	1.89561e-08	1	0	T	240969562	T	T	240969562	2	4	180	1	0	0	0	0	0	0	0	1	11242	1045	37	3		3	OR6B2	2	240969562	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08	38838064	240969562	2229811	14	33828											
CADM2	253559	broad.mit.edu	37	chr3	86114798	86114798	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatggccctgaccatgctctCataggaggaatagtggctgt	10	10	12	9	0	1	1	1	1	1	0	2	3	1	3	2	4	1	2	2	4	4	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr3:86114798C>T	uc003dqj.2	+	9	1733	c.1107C>T	c.(1105-1107)CTC>CTT	p.L369L	CADM2_uc003dqk.2_Silent_p.L338L|CADM2_uc003dql.2_Silent_p.L371L	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	369	Helical; (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		ACCATGCTCTCATAGGAGGAA	0.403													6	18					0	0	0	0	T	86114798	T	T	86114798	2	4	180	1	0	0	0	0	0	0	0	1	2579	813	29	2		2	CADM2	3	86114798	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08		86114798	111907632	15	33829											
ABHD10	55347	broad.mit.edu	37	chr3	111697969	111697969	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttgtcggagctggggctggGcagccgtccccttcggtccc	2	9	15	15	3	0	0	0	0	0	0	4	1	2	1	4	5	2	3	4	5	0	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr3:111697969G>T	uc003dyk.3	+	1	142	c.61G>T	c.(61-63)GCA>TCA	p.A21S	ABHD10_uc011bhq.1_5'UTR	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	21						mitochondrion	serine-type peptidase activity				0						CTGGGGCTGGGCAGCCGTCCC	0.687													6	31					0.00116845	0.00121339	1	0	T	111697969	T	T	111697969	3	4	180	1	0	0	0	0	1	0	0	0	74	1203	42	4	63	4	ABHD10	3	111697969	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	25583171	111697969	86324461	16	33830											
CCDC80	151887	broad.mit.edu	37	chr3	112324383	112324383	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atactcatcttctgggcagcGcatccccagtgactgctgaa	9	10	9	13	1	3	2	1	2	2	0	4	2	4	2	2	1	3	3	2	1	2	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr3:112324383G>A	uc003dzf.2	-	8	2952	c.2734C>T	c.(2734-2736)CGC>TGC	p.R912C	CCDC80_uc011bhv.1_Missense_Mutation_p.R885C|CCDC80_uc003dzg.2_Missense_Mutation_p.R912C	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	912										ovary(2)	2						TCTGGGCAGCGCATCCCCAGT	0.473													3	38					0	0	0	0	A	112324383	A	A	112324383	3	1	180	1	0	0	0	0	1	0	0	0	2867	1087	38	1	122	1	CCDC80	3	112324383	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	626414	112324383	85698047	17	33831											
GP5	2814	broad.mit.edu	37	chr3	194118839	194118839	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacgccgcggcccattccgAagagcaggatgtgcgtgagg	8	5	17	11	5	0	2	0	1	0	1	1	5	1	4	3	4	2	1	3	4	1	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr3:194118839A>T	uc003ftv.1	-	2	204	c.173T>A	c.(172-174)TTC>TAC	p.F58Y		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	58	Extracellular (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		GCCCATTCCGAAGAGCAGGAT	0.677													46	73					0	0	0	0	T	194118839	T	T	194118839	3	4	180	1	0	0	0	0	1	0	0	0	6621	246	9	5	1513	5	GP5	3	194118839	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	81794456	194118839	3903591	18	33832											
NAT8L	339983	broad.mit.edu	37	chr4	2065645	2065645	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgctgggccggaaggtgctgGagttcgccgtggtgcacaac	6	7	17	11	4	0	0	0	0	0	0	1	2	0	2	2	5	3	4	2	5	2	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr4:2065645G>A	uc003geq.1	+	3	352	c.196G>A	c.(196-198)GAG>AAG	p.E66K		NM_178557	NP_848652	Q8N9F0	NAT8L_HUMAN	N-acetyltransferase 8-like (GCN5-related,	234	N-acetyltransferase.					integral to membrane|microsome|mitochondrial membrane|rough endoplasmic reticulum membrane	aspartate N-acetyltransferase activity				0			OV - Ovarian serous cystadenocarcinoma(23;0.0315)			GAAGGTGCTGGAGTTCGCCGT	0.652													6	24					0	0	0	0	A	2065645	A	A	2065645	3	1	180	1	0	0	0	0	1	0	0	0	10234	1175	41	2	710	2	NAT8L	4	2065645	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08		2065645	189088631	19	33833											
UGDH	7358	broad.mit.edu	37	chr4	39512453	39512453	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgcccggcctttccccAttccataggtttttgttgga	4	15	9	13	1	0	0	0	0	0	0	2	1	2	1	5	3	2	3	5	3	1	6			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr4:39512453A>G	uc003guk.1	-	4	609	c.293T>C	c.(292-294)ATG>ACG	p.M98T	UGDH_uc011byp.1_Missense_Mutation_p.M1T|UGDH_uc003gul.1_Intron	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	98					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	GCCTTTCCCCATTCCATAGGT	0.413													20	67					0	0	0	0	G	39512453	G	G	39512453	3	3	180	1	0	0	0	0	1	0	0	0	17008	217	8	5	1227	5	UGDH	4	39512453	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	37446808	39512453	151641823	20	33834											
NFXL1	152518	broad.mit.edu	37	chr4	47898591	47898591	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caacgctgtgaacatctatgGattccgcattcaagtacttt	11	13	7	10	2	2	1	1	1	1	0	3	2	3	2	1	1	3	3	1	1	5	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr4:47898591G>A	uc010igh.2	-	10	1455	c.1278C>T	c.(1276-1278)ATC>ATT	p.I426I	NFXL1_uc003gxp.2_Silent_p.I426I|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Silent_p.I426I	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	426						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						AACATCTATGGATTCCGCATT	0.373													7	38					0	0	0	0	A	47898591	A	A	47898591	2	1	180	1	0	0	0	0	0	0	0	1	10442	1164	41	2		2	NFXL1	4	47898591	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08	8386138	47898591	143255685	21	33835											
UGT2B28	54490	broad.mit.edu	37	chr4	70156431	70156431	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcaacctgataacattgcTcacatgaaggccaagggagc	14	7	10	10	0	2	2	2	2	0	0	2	4	2	3	2	2	4	1	2	2	4	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr4:70156431T>A	uc003hej.2	+	5	1214	c.1212T>A	c.(1210-1212)GCT>GCA	p.A404A	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	404					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	ATAACATTGCTCACATGAAGG	0.453													21	129					0	0	0	0	A	70156431	A	A	70156431	2	1	180	1	0	0	0	0	0	0	0	1	17028	1538	54	5		5	UGT2B28	4	70156431	Silent	SNP	T	TCGA-CV-5966-01A-11D-1683-08	22257840	70156431	120997845	22	33836											
UGT2B28	54490	broad.mit.edu	37	chr4	70156461	70156462	+	Missense_Mutation	DNP	AC	TT	TT																															gccaagggagcagctgttagActggacttccacacaatgtc																										TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr4:70156461_70156462AC>TT	uc003hej.2	+	5	1244_1245	c.1242_1243AC>TT	c.(1240-1245)AGACTG>AGTTTG	p.R414S	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	414					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	CAGCTGTTAGACTGGACTTCCA	0.441													12	132					0	0	0	0	TT	70156462	TT	TT	70156461	3	4	180	1	0	0	0	0	1	0	0	0	17028	272	10	5	1260	5	UGT2B28	4	70156461	Missense_Mutation	DNP	AC	TCGA-CV-5966-01A-11D-1683-08	30	70156461	120997815	23	33837											
SHROOM3	57619	broad.mit.edu	37	chr4	77661382	77661382	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agctaggccggggaacccagGagggttaccccgggggcagg	8	3	19	11	2	0	0	0	0	0	0	0	2	0	2	4	8	3	3	4	8	3	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr4:77661382G>A	uc011cbx.1	+	5	3009	c.2056G>A	c.(2056-2058)GAG>AAG	p.E686K	SHROOM3_uc011cbz.1_Missense_Mutation_p.E510K|SHROOM3_uc003hkf.1_Missense_Mutation_p.E561K|SHROOM3_uc003hkg.2_Missense_Mutation_p.E464K	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	686					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GGGAACCCAGGAGGGTTACCC	0.607													53	72					0	0	0	0	A	77661382	A	A	77661382	3	1	180	1	0	0	0	0	1	0	0	0	14360	1175	41	2	2074	2	SHROOM3	4	77661382	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	7504921	77661382	113492894	24	33838											
RRH	10692	broad.mit.edu	37	chr4	110758732	110758732	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactgagtccctcaacagaGactggtcagatcagatagat	13	8	10	10	0	3	5	3	1	0	4	4	6	4	5	1	1	1	1	1	1	2	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr4:110758732G>T	uc003hzv.2	+	5	725	c.691G>T	c.(691-693)GAC>TAC	p.D231Y		NM_006583	NP_006574	O14718	OPSX_HUMAN	peropsin	231	Cytoplasmic.				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		CCTCAACAGAGACTGGTCAGA	0.403													7	23					0.000157383	0.000164491	1	0	T	110758732	T	T	110758732	3	4	180	1	0	0	0	0	1	0	0	0	13745	942	33	2	709	2	RRH	4	110758732	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	33097350	110758732	80395544	25	33839											
TKTL2	84076	broad.mit.edu	37	chr4	164394114	164394114	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctttccatgccaattttctGcatcctcaatatttggaata	10	16	5	10	0	2	0	1	0	1	0	4	1	4	1	3	1	2	2	3	1	5	6			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr4:164394114G>T	uc003iqp.3	-	1	934	c.773C>A	c.(772-774)GCA>GAA	p.A258E		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	258						cytoplasm	metal ion binding|transketolase activity	p.A258V(1)		ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCAATTTTCTGCATCCTCAAT	0.408													24	93					5.61819e-17	6.32046e-17	1	0	T	164394114	T	T	164394114	3	4	180	1	0	0	0	0	1	0	0	0	16002	1319	46	4	1111	4	TKTL2	4	164394114	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	53635382	164394114	26760162	26	33840											
KIAA1712	80817	broad.mit.edu	37	chr4	175232005	175232005	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgacatggaccttctgaaTcctcgtaagtttgtaaatac	12	13	8	8	1	1	2	0	2	1	0	3	3	2	3	2	1	1	3	2	1	5	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr4:175232005T>G	uc003itr.2	+	9	1371	c.957T>G	c.(955-957)AAT>AAG	p.N319K	KIAA1712_uc010iro.2_Missense_Mutation_p.N319K|KIAA1712_uc003its.2_RNA	NM_001040157	NP_001035247	Q9C0F1	CEP44_HUMAN	HBV PreS1-transactivated protein 3 isoform a	319						centrosome|midbody|spindle pole					0		Prostate(90;0.00276)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;4.06e-18)|Epithelial(43;1.18e-15)|OV - Ovarian serous cystadenocarcinoma(60;4.65e-09)|GBM - Glioblastoma multiforme(59;0.00098)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0949)		ACCTTCTGAATCCTCGTAAGT	0.274													22	65					0	0	0	0	G	175232005	G	G	175232005	3	3	180	1	0	0	0	0	1	0	0	0	8292	1432	50	5	983	5	KIAA1712	4	175232005	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	10837891	175232005	15922271	27	33841											
FAT1	2195	broad.mit.edu	37	chr4	187524850	187524850	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gttacgctgacattgagaagGtattgccctatgtctagctt	9	14	10	8	1	1	2	0	2	1	1	1	3	1	2	1	1	3	4	1	1	5	7			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr4:187524850G>C	uc003izf.2	-	19	11018	c.10830C>G	c.(10828-10830)TAC>TAG	p.Y3610*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3610	Extracellular (Potential).|Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CATTGAGAAGGTATTGCCCTA	0.498										HNSCC(5;0.00058)			6	20					0	0	0	0	C	187524850	C	C	187524850	4	2	180	1	0	0	0	0	0	1	0	0	5721	1256	44	4	2972	4	FAT1	4	187524850	Nonsense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	12292845	187524850	3629426	28	33842											
VCAN	1462	broad.mit.edu	37	chr5	82817939	82817939	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atattgtagccaaggaaacaGaaaccgatattgatagagag	18	8	10	5	1	0	3	0	1	0	2	0	6	0	4	2	1	3	1	2	1	7	6			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr5:82817939G>A	uc003kii.3	+	7	4170	c.3814G>A	c.(3814-3816)GAA>AAA	p.E1272K	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.E1272K|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1272	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAAGGAAACAGAAACCGATAT	0.453													10	68					0	0	0	0	A	82817939	A	A	82817939	3	1	180	1	0	0	0	0	1	0	0	0	17206	943	33	2	3836	2	VCAN	5	82817939	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08		82817939	98097321	29	33843											
FAM172A	83989	broad.mit.edu	37	chr5	93294538	93294538	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgtccagatcttcatttaTaataagtcttctagcccact	11	15	4	11	0	4	1	1	0	3	1	5	1	5	1	2	0	1	0	2	0	4	7			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr5:93294538T>C	uc010jbd.2	-	6	718	c.511A>G	c.(511-513)ATA>GTA	p.I171V	FAM172A_uc011cuf.1_Missense_Mutation_p.I125V|FAM172A_uc011cug.1_Intron|FAM172A_uc011cuh.1_Intron|FAM172A_uc011cui.1_RNA|FAM172A_uc011cuj.1_Intron|FAM172A_uc003kkm.3_Missense_Mutation_p.I171V	NM_032042	NP_114431	Q8WUF8	F172A_HUMAN	hypothetical protein LOC83989 isoform 1	171						endoplasmic reticulum|extracellular region					0						TCTTCATTTATAATAAGTCTT	0.388													16	81					0	0	0	0	C	93294538	C	C	93294538	3	2	180	1	0	0	0	0	1	0	0	0	5520	1406	49	5	763	5	FAM172A	5	93294538	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	10476599	93294538	87620722	30	33844											
NUDT12	83594	broad.mit.edu	37	chr5	102894926	102894926	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttaaatctgagaaaagaatAaaaactgtggctggatggct	16	11	10	4	0	1	2	0	1	1	2	1	4	1	3	0	3	1	2	0	3	8	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr5:102894926A>T	uc003koi.2	-	3	543	c.450T>A	c.(448-450)TTT>TTA	p.F150L	NUDT12_uc011cvb.1_Missense_Mutation_p.F132L	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	150						nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		AGAAAAGAATAAAAACTGTGG	0.378													8	42					0	0	0	0	T	102894926	T	T	102894926	3	4	180	1	0	0	0	0	1	0	0	0	10782	359	13	5	958	5	NUDT12	5	102894926	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	9600388	102894926	78020334	31	33845											
KIF3A	11127	broad.mit.edu	37	chr5	132069993	132069993	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccaaaaacagtatcaaaagTaaatgtctttggaggttcat	16	12	7	6	0	3	0	2	0	1	0	4	1	4	1	1	2	1	3	1	2	7	4			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr5:132069993T>G	uc003kxo.2	-	2	338	c.184A>C	c.(184-186)ACT>CCT	p.T62P	KIF3A_uc003kxn.2_Missense_Mutation_p.T21P|KIF3A_uc011cxf.1_Missense_Mutation_p.T62P|KIF3A_uc003kxp.2_Missense_Mutation_p.T62P	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	62	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTATCAAAAGTAAATGTCTTT	0.368													38	126					0	0	0	0	G	132069993	G	G	132069993	3	3	180	1	0	0	0	0	1	0	0	0	8339	1638	57	5	1979	5	KIF3A	5	132069993	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	29175067	132069993	48845267	32	33846											
PCDHA4	56144	broad.mit.edu	37	chr5	140188217	140188217	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgtgtctgcgtgggacgCggacgcgcaggagaacgcgc	7	5	17	12	7	1	1	0	0	1	1	1	4	1	3	0	3	2	1	0	3	1	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr5:140188217C>T	uc003lhi.2	+	1	1546	c.1445C>T	c.(1444-1446)GCG>GTG	p.A482V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.A482V|PCDHA4_uc011daa.1_Missense_Mutation_p.A482V	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	482	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTGGGACGCGGACGCGCAG	0.657													16	59					0	0	0	0	T	140188217	T	T	140188217	3	4	180	1	0	0	0	0	1	0	0	0	11580	768	27	1	1447	1	PCDHA4	5	140188217	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	8118224	140188217	40727043	33	33847											
PCDHB8	56128	broad.mit.edu	37	chr5	140558908	140558908	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	actgacttagggacacccagGctgacaacacatctcaatat	14	8	7	12	0	1	2	1	2	1	0	2	3	1	3	1	2	1	1	1	2	4	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr5:140558908G>C	uc011dai.1	+	1	1479	c.1293G>C	c.(1291-1293)AGG>AGC	p.R431S	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	431	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACACCCAGGCTGACAACAC	0.532													19	69					0	0	0	0	C	140558908	C	C	140558908	3	2	180	1	0	0	0	0	1	0	0	0	11602	1194	42	4	1295	4	PCDHB8	5	140558908	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	370691	140558908	40356352	34	33848											
PCDHB15	56121	broad.mit.edu	37	chr5	140627104	140627104	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caatggcgagcctccgcgctCggccaccgccacgctgcaag	7	4	12	18	6	0	0	0	0	0	0	2	1	1	0	5	2	2	3	5	2	2	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr5:140627104C>T	uc003lje.2	+	1	1958	c.1958C>T	c.(1957-1959)TCG>TTG	p.S653L		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	653	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCCGCGCTCGGCCACCGCC	0.697													19	60					0	0	0	0	T	140627104	T	T	140627104	3	4	180	1	0	0	0	0	1	0	0	0	11594	893	31	1	1960	1	PCDHB15	5	140627104	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	68196	140627104	40288156	35	33849											
FGF1	2246	broad.mit.edu	37	chr5	141974914	141974914	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttctggccatagtgagtccGaggaccgcgtttgcagctcc	6	11	12	12	3	1	1	0	1	1	0	3	3	3	2	4	2	2	3	4	2	1	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr5:141974914G>A	uc003lmm.2	-	4	489	c.409C>T	c.(409-411)CGG>TGG	p.R137W	FGF1_uc011dbi.1_3'UTR|FGF1_uc003lmn.3_Missense_Mutation_p.R137W|FGF1_uc003lmp.3_3'UTR|FGF1_uc003lmq.2_Missense_Mutation_p.R137W|FGF1_uc010jgj.2_Missense_Mutation_p.R136W|FGF1_uc003lmr.2_Missense_Mutation_p.R137W|FGF1_uc003lms.3_Missense_Mutation_p.R137W	NM_001144892	NP_001138364	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic) isoform 1	137	Heparin-binding.				angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding				0		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	TAGTGAGTCCGAGGACCGCGT	0.478													15	41					0	0	0	0	A	141974914	A	A	141974914	3	1	180	1	0	0	0	0	1	0	0	0	5870	1057	37	1	62	1	FGF1	5	141974914	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	1347810	141974914	38940346	36	33850											
TCERG1	10915	broad.mit.edu	37	chr5	145878147	145878147	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgctaaagattcaagattCaaagcaattgaaaagatgaa	20	9	7	5	0	2	5	2	2	0	3	2	5	2	5	0	0	2	2	0	0	8	4			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr5:145878147C>G	uc003lob.2	+	16	2320	c.2280C>G	c.(2278-2280)TTC>TTG	p.F760L	TCERG1_uc003loc.2_Missense_Mutation_p.F739L	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	760	FF 2.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTCAAGATTCAAAGCAATTG	0.388													16	43					0	0	0	0	G	145878147	G	G	145878147	3	3	180	1	0	0	0	0	1	0	0	0	15751	825	29	2	2342	2	TCERG1	5	145878147	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	3903233	145878147	35037113	37	33851											
ATP10B	23120	broad.mit.edu	37	chr5	160063201	160063201	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctacctggagcaggatGatcattgtgaggaacatgta	11	11	11	8	0	1	2	1	2	0	0	2	5	2	5	2	3	3	2	2	3	3	4			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr5:160063201G>T	uc003lym.1	-	11	1963	c.1116C>A	c.(1114-1116)ATC>ATA	p.I372I	ATP10B_uc003lyp.2_Silent_p.I372I|ATP10B_uc011deg.1_Silent_p.I416I|ATP10B_uc003lyn.2_5'Flank|ATP10B_uc003lyo.2_Silent_p.I344I	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	372	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGAGCAGGATGATCATTGTGA	0.493													10	48					3.86212e-05	4.06275e-05	1	0	T	160063201	T	T	160063201	2	4	180	1	0	0	0	0	0	0	0	1	1119	1280	45	2		2	ATP10B	5	160063201	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08	14185054	160063201	20852059	38	33852											
HIST1H2AH	85235	broad.mit.edu	37	chr6	27115271	27115271	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgctgcctaagaagactGagagccaccataaggccaaa	14	6	10	11	0	0	3	0	1	0	3	0	4	0	3	4	1	4	2	4	1	4	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr6:27115271G>A	uc003niz.2	+	1	364	c.364G>A	c.(364-366)GAG>AAG	p.E122K	HIST1H2BK_uc003nix.1_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080596	NP_542163	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	122					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TAAGAAGACTGAGAGCCACCA	0.522													5	43					0	0	0	0	A	27115271	A	A	27115271	3	1	180	1	0	0	0	0	1	0	0	0	7173	1291	45	2	366	2	HIST1H2AH	6	27115271	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08		27115271	143999796	39	33853											
VARS	7407	broad.mit.edu	37	chr6	31749380	31749380	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagaacacactcaggtcttCtgactgagggcagaccaggg	11	7	13	10	0	3	4	1	2	2	2	3	4	3	4	1	3	1	2	1	3	2	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr6:31749380C>T	uc003nxe.2	-	21	2845	c.2422G>A	c.(2422-2424)GAA>AAA	p.E808K	VARS_uc003nxf.1_5'Flank	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	808					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	CTCAGGTCTTCTGACTGAGGG	0.637													13	40					0	0	0	0	T	31749380	T	T	31749380	3	4	180	1	0	0	0	0	1	0	0	0	17191	922	32	2	1412	2	VARS	6	31749380	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	4634109	31749380	139365687	40	33854											
TFEB	7942	broad.mit.edu	37	chr6	41655657	41655657	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggcagtacctgtgagctctCgcttctgggtcaggtccgca	6	10	13	12	2	3	1	1	1	2	0	5	1	4	1	2	3	2	5	2	3	1	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr6:41655657C>T	uc003oqs.1	-	6	961	c.659G>A	c.(658-660)CGA>CAA	p.R220Q	TFEB_uc003oqt.1_Missense_Mutation_p.R220Q|TFEB_uc003oqu.1_Missense_Mutation_p.R234Q|TFEB_uc003oqv.1_Missense_Mutation_p.R220Q|TFEB_uc010jxo.1_Missense_Mutation_p.R220Q|TFEB_uc003oqr.1_Missense_Mutation_p.R135Q	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	220					embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			TGTGAGCTCTCGCTTCTGGGT	0.478			T	ALPHA	renal (childhood epithelioid)								14	53					0	0	0	0	T	41655657	T	T	41655657	3	4	180	1	0	0	0	0	1	0	0	0	15867	884	31	1	791	1	TFEB	6	41655657	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	9906277	41655657	129459410	41	33855											
KIAA1919	91749	broad.mit.edu	37	chr6	111587430	111587430	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcatctgctgagacatttcGaagagcaaaatatcacaacg	16	8	8	9	2	2	2	1	1	1	2	3	4	2	2	0	0	4	3	0	0	5	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr6:111587430G>A	uc003puv.3	+	4	1087	c.665G>A	c.(664-666)CGA>CAA	p.R222Q		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	222	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		GAGACATTTCGAAGAGCAAAA	0.343													13	32					0	0	0	0	A	111587430	A	A	111587430	3	1	180	1	0	0	0	0	1	0	0	0	8301	1058	37	1	679	1	KIAA1919	6	111587430	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	69931773	111587430	59527637	42	33856											
ROS1	6098	broad.mit.edu	37	chr6	117687343	117687343	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctatttcttgagttgtgataAtcctaaagccattgatccag	11	15	7	8	0	1	3	0	3	1	0	3	3	3	3	3	0	1	1	3	0	4	7			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr6:117687343A>C	uc003pxp.1	-	18	2907	c.2708T>G	c.(2707-2709)ATT>AGT	p.I903S	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	903	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AGTTGTGATAATCCTAAAGCC	0.423			T	GOPC|ROS1	glioblastoma|NSCLC								16	106					0	0	0	0	C	117687343	C	C	117687343	3	2	180	1	0	0	0	0	1	0	0	0	13596	101	4	5	4439	5	ROS1	6	117687343	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	6099913	117687343	53427724	43	33857											
SERINC1	57515	broad.mit.edu	37	chr6	122777667	122777667	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggatcactgctactcttcacTttgatcattagtaaagagag	12	13	8	8	0	4	2	3	1	1	1	4	4	4	3	0	1	2	2	0	1	4	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr6:122777667T>C	uc003pyy.1	-	3	400	c.330A>G	c.(328-330)AAA>AAG	p.K110K		NM_020755	NP_065806	Q9NRX5	SERC1_HUMAN	serine incorporator 1	110	Cytoplasmic (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	L-serine transmembrane transporter activity|protein binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.126)		TACTCTTCACTTTGATCATTA	0.378													11	38					0	0	0	0	C	122777667	C	C	122777667	2	2	180	1	0	0	0	0	0	0	0	1	14144	1606	56	5		5	SERINC1	6	122777667	Silent	SNP	T	TCGA-CV-5966-01A-11D-1683-08	5090324	122777667	48337400	44	33858											
BCLAF1	9774	broad.mit.edu	37	chr6	136597369	136597369	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtacttgagtccttcctcctCagtattccggtgagatgcag	7	13	10	11	1	1	2	1	2	0	1	5	3	5	2	4	1	2	3	4	1	2	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr6:136597369C>T	uc003qgx.1	-	5	1547	c.1294G>A	c.(1294-1296)GAG>AAG	p.E432K	BCLAF1_uc003qgw.1_Intron|BCLAF1_uc003qgy.1_Missense_Mutation_p.E430K|BCLAF1_uc011edc.1_Intron|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.E430K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	432					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CCTTCCTCCTCAGTATTCCGG	0.413													13	218					0	0	0	0	T	136597369	T	T	136597369	3	4	180	1	0	0	0	0	1	0	0	0	1385	835	29	2	1504	2	BCLAF1	6	136597369	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	13819702	136597369	34517698	45	33859											
MAP7	9053	broad.mit.edu	37	chr6	136710510	136710510	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actttgtcctcctcaagtctCtgcctccgcttctcctccac	4	14	4	19	1	3	0	1	0	2	0	9	0	7	0	6	0	1	1	6	0	1	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr6:136710510C>G	uc003qgz.2	-	4	636	c.390G>C	c.(388-390)CAG>CAC	p.Q130H	MAP7_uc011edf.1_Missense_Mutation_p.Q115H|MAP7_uc011edg.1_Missense_Mutation_p.Q152H|MAP7_uc010kgu.2_Missense_Mutation_p.Q152H|MAP7_uc011edh.1_Missense_Mutation_p.Q152H|MAP7_uc010kgv.2_Missense_Mutation_p.Q152H|MAP7_uc010kgs.2_5'UTR|MAP7_uc011edi.1_5'UTR|MAP7_uc010kgq.1_Intron|MAP7_uc003qha.1_Missense_Mutation_p.Q130H|MAP7_uc010kgr.2_Intron|MAP7_uc010kgt.2_Missense_Mutation_p.Q152H	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	130	Potential.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		CCTCAAGTCTCTGCCTCCGCT	0.562													20	89					0	0	0	0	G	136710510	G	G	136710510	3	3	180	1	0	0	0	0	1	0	0	0	9319	912	32	2	1919	2	MAP7	6	136710510	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	113141	136710510	34404557	46	33860											
SYNE1	23345	broad.mit.edu	37	chr6	152694261	152694261	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggcctggatccctttcgCtttctctttggtcagcaggg	3	16	11	11	1	2	0	1	0	1	0	5	1	3	1	2	4	1	2	2	4	0	4			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr6:152694261C>T	uc010kiw.2	-	59	10020	c.9418G>A	c.(9418-9420)GCG>ACG	p.A3140T	SYNE1_uc003qot.3_Missense_Mutation_p.A3147T|SYNE1_uc003qou.3_Missense_Mutation_p.A3140T|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_Missense_Mutation_p.A218T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3140	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATCCCTTTCGCTTTCTCTTTG	0.393										HNSCC(10;0.0054)			29	118					0	0	0	0	T	152694261	T	T	152694261	3	4	180	1	0	0	0	0	1	0	0	0	15511	797	28	4	17400	4	SYNE1	6	152694261	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	15983751	152694261	18420806	47	33861											
THSD7A	221981	broad.mit.edu	37	chr7	11630197	11630197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagggccgtctggttgccgCgcctcttgtcctgctgactg	3	11	14	13	3	2	2	0	1	2	1	3	2	3	2	4	2	2	2	4	2	0	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr7:11630197C>T	uc003ssf.3	-	4	1595	c.1343G>A	c.(1342-1344)CGC>CAC	p.R448H		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	448	Extracellular (Potential).|TSP type-1 4.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTGGTTGCCGCGCCTCTTGTC	0.557										HNSCC(18;0.044)			9	29					0	0	0	0	T	11630197	T	T	11630197	3	4	180	1	0	0	0	0	1	0	0	0	15945	768	27	1	3726	1	THSD7A	7	11630197	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08		11630197	147508466	48	33862											
NPY	4852	broad.mit.edu	37	chr7	24324986	24324986	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgggcgaggacgcaccagcgGaggacatggccagatactac	11	3	15	12	4	0	1	0	0	0	1	0	5	0	4	2	5	3	1	2	5	2	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr7:24324986G>A	uc003sww.1	+	2	213	c.127G>A	c.(127-129)GAG>AAG	p.E43K		NM_000905	NP_000896	P01303	NPY_HUMAN	neuropeptide Y precursor	43					adult feeding behavior|calcium ion transport|cell proliferation|cellular component movement|central nervous system neuron development|cerebral cortex development|digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|neuron projection development|neuropeptide signaling pathway|positive regulation of appetite|synaptic transmission	cell|extracellular space	calcium channel regulator activity|G-protein coupled receptor activity|neuropeptide hormone activity				0						CGCACCAGCGGAGGACATGGC	0.682													7	27					0	0	0	0	A	24324986	A	A	24324986	3	1	180	1	0	0	0	0	1	0	0	0	10661	1175	41	2	129	2	NPY	7	24324986	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	12694789	24324986	134813677	49	33863											
UPP1	7378	broad.mit.edu	37	chr7	48146983	48146983	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccgtctggatggggctctCtgctcctacacggagaagga	7	8	15	11	2	2	1	0	0	2	1	4	4	3	3	2	6	2	2	2	6	2	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr7:48146983C>G	uc003toj.2	+	9	1201	c.672C>G	c.(670-672)CTC>CTG	p.L224L	UPP1_uc003tok.2_Silent_p.L224L|UPP1_uc003tol.2_Silent_p.L224L|UPP1_uc011kch.1_Silent_p.L17L|UPP1_uc003ton.2_Silent_p.L87L|UPP1_uc003too.2_Silent_p.L87L	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	224					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						ATGGGGCTCTCTGCTCCTACA	0.582													21	36					0	0	0	0	G	48146983	G	G	48146983	2	3	180	1	0	0	0	0	0	0	0	1	17080	900	32	2		2	UPP1	7	48146983	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08	23821997	48146983	110991680	50	33864											
ZNF107	51427	broad.mit.edu	37	chr7	64167053	64167053	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaactaactcagcatagaaGaattcatactagagtgaatt	18	10	6	7	0	2	4	2	1	0	3	2	4	2	4	0	0	4	1	0	0	8	6			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr7:64167053G>A	uc003ttd.2	+	7	1157	c.371G>A	c.(370-372)AGA>AAA	p.R124K	ZNF107_uc003tte.2_Missense_Mutation_p.R124K	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	124	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CAGCATAGAAGAATTCATACT	0.328													6	27					0	0	0	0	A	64167053	A	A	64167053	3	1	180	1	0	0	0	0	1	0	0	0	17782	942	33	2	377	2	ZNF107	7	64167053	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	16020070	64167053	94971610	51	33865											
PCLO	27445	broad.mit.edu	37	chr7	82585177	82585177	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggctttccatttccaattCtggctcttcgtcaaaataca	10	14	5	12	1	3	0	1	0	2	0	6	0	5	0	2	2	1	2	2	2	4	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr7:82585177C>T	uc003uhx.2	-	5	5381	c.5092G>A	c.(5092-5094)GAA>AAA	p.E1698K	PCLO_uc003uhv.2_Missense_Mutation_p.E1698K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1629					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATTTCCAATTCTGGCTCTTCG	0.433													8	26					0	0	0	0	T	82585177	T	T	82585177	3	4	180	1	0	0	0	0	1	0	0	0	11637	922	32	2	10437	2	PCLO	7	82585177	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	18418124	82585177	76553486	52	33866											
SLC12A9	56996	broad.mit.edu	37	chr7	100457855	100457855	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attcttggggcctggtgcagGtgagccttcttcttcaaggg	5	13	14	9	0	4	1	1	1	3	0	4	1	4	1	2	5	2	1	2	5	1	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr7:100457855G>A	uc003uwp.2	+	9	1360	c.1218_splice	c.e9+1	p.Q406_splice	SLC12A9_uc003uwq.2_Splice_Site_p.Q317_splice|SLC12A9_uc011kki.1_Translation_Start_Site|SLC12A9_uc003uwr.2_Splice_Site_p.Q142_splice|SLC12A9_uc003uws.2_Translation_Start_Site|SLC12A9_uc003uwt.2_Splice_Site_p.Q142_splice|SLC12A9_uc003uwv.2_Translation_Start_Site	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride							integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCTGGTGCAGGTGAGCCTTCT	0.562													8	26					0	0	0	0	A	100457855	A	A	100457855	5	1	180	1	0	0	0	0	0	0	1	0	14455	1275	44	4	1249	4	SLC12A9	7	100457855	Splice_Site	SNP	G	TCGA-CV-5966-01A-11D-1683-08	17872678	100457855	58680808	53	33867											
PLOD3	8985	broad.mit.edu	37	chr7	100859997	100859997	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcacagtgtagttgaagaaCtccgcagagcgcaggaaacg	13	5	13	10	4	0	3	0	1	0	2	1	4	1	4	1	1	3	5	1	1	4	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr7:100859997C>T	uc003uyd.2	-	2	636	c.180G>A	c.(178-180)GAG>GAA	p.E60E	ZNHIT1_uc003uye.2_5'Flank|ZNHIT1_uc003uyf.2_5'Flank	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	60					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	AGTTGAAGAACTCCGCAGAGC	0.607													7	30					0	0	0	0	T	100859997	T	T	100859997	2	4	180	1	0	0	0	0	0	0	0	1	12158	564	20	4		4	PLOD3	7	100859997	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08	402142	100859997	58278666	54	33868											
CFTR	1080	broad.mit.edu	37	chr7	117292972	117292972	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagtgatcaagaaatatggaAagttgcagatgaggtaaggc	16	8	14	3	0	1	4	1	2	0	2	1	6	1	5	0	3	1	3	0	3	5	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr7:117292972A>C	uc003vjd.2	+	24	4082	c.3950A>C	c.(3949-3951)AAA>ACA	p.K1317T	CFTR_uc011knq.1_Missense_Mutation_p.K723T	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	1317	Cytoplasmic (Potential).|ABC transporter 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GAAATATGGAAAGTTGCAGAT	0.338									Cystic_Fibrosis				8	32					0	0	0	0	C	117292972	C	C	117292972	3	2	180	1	0	0	0	0	1	0	0	0	3309	14	1	5	4044	5	CFTR	7	117292972	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	16432975	117292972	41845691	55	33869											
HR	55806	broad.mit.edu	37	chr8	21986633	21986633	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgatgccgttctctggggcCgtcttctcccaggttggggt	3	12	14	12	3	3	0	0	0	3	0	5	1	3	0	3	5	1	2	3	5	0	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr8:21986633C>T	uc003xas.2	-	2	716	c.51G>A	c.(49-51)ACG>ACA	p.T17T	HR_uc003xat.2_Silent_p.T17T|HR_uc010lts.2_Silent_p.T17T	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	17							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		TCTCTGGGGCCGTCTTCTCCC	0.652													4	78					0	0	0	0	T	21986633	T	T	21986633	2	4	180	1	0	0	0	0	0	0	0	1	7386	639	23	1		1	HR	8	21986633	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08		21986633	124377389	56	33870											
ADRA1A	148	broad.mit.edu	37	chr8	26627932	26627932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggtctctcttgatcccaCggggatgcgcaccatgtcct	7	10	11	13	2	2	1	0	1	2	0	5	3	4	2	3	3	1	1	3	3	1	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr8:26627932C>T	uc003xfh.1	-	2	1571	c.1135G>A	c.(1135-1137)GTG>ATG	p.V379M	ADRA1A_uc003xfc.1_Missense_Mutation_p.V379M|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Missense_Mutation_p.V379M|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron|ADRA1A_uc003xfg.1_Missense_Mutation_p.V379M	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	379	Cytoplasmic (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	CTTGATCCCACGGGGATGCGC	0.552													23	78					0	0	0	0	T	26627932	T	T	26627932	3	4	180	1	0	0	0	0	1	0	0	0	334	536	19	1	560	1	ADRA1A	8	26627932	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	4641299	26627932	119736090	57	33871											
DCAF13	25879	broad.mit.edu	37	chr8	104453792	104453792	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatcgacatctaccaaaatCtatctatagccagattcagg	14	11	5	11	1	5	1	2	0	3	1	6	2	5	1	2	1	2	0	2	1	6	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr8:104453792C>G	uc003yln.2	+	10	1929	c.1652C>G	c.(1651-1653)TCT>TGT	p.S551C	DCAF13_uc003ylo.2_Missense_Mutation_p.S262C	NM_015420	NP_056235	Q9NV06	DCA13_HUMAN	WD repeats and SOF1 domain containing	399					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1						CTACCAAAATCTATCTATAGC	0.393													26	112					0	0	0	0	G	104453792	G	G	104453792	3	3	180	1	0	0	0	0	1	0	0	0	4283	913	32	2	1690	2	DCAF13	8	104453792	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	77825860	104453792	41910230	58	33872											
TTC35	9694	broad.mit.edu	37	chr8	109465334	109465334	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagttccctggcagtcacaGagtcaagcgattaacaggca	13	7	10	11	1	2	1	2	0	0	1	3	2	3	1	1	2	2	3	1	2	2	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr8:109465334G>C	uc003ymw.1	+	4	298	c.263G>C	c.(262-264)AGA>ACA	p.R88T		NM_014673	NP_055488	Q15006	TTC35_HUMAN	tetratricopeptide repeat domain 35	88	TPR 1.					endoplasmic reticulum|nucleus	binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.34e-10)			GGCAGTCACAGAGTCAAGCGA	0.398													5	38					0	0	0	0	C	109465334	C	C	109465334	3	2	180	1	0	0	0	0	1	0	0	0	16771	942	33	2	277	2	TTC35	8	109465334	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	5011542	109465334	36898688	59	33873											
CYC1	1537	broad.mit.edu	37	chr8	145150852	145150852	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggctctgcattcggctgtGagtgccagtgacctggagct	6	11	14	10	1	1	2	0	2	1	0	2	3	1	3	2	3	3	4	2	3	0	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr8:145150852G>C	uc003zaz.3	+	2	289	c.246G>C	c.(244-246)GTG>GTC	p.V82V	CYC1_uc003zay.2_Silent_p.V23V	NM_001916	NP_001907	P08574	CY1_HUMAN	cytochrome c-1	82					respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ATTCGGCTGTGAGTGCCAGTG	0.662											OREG0019052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	71					0	0	0	0	C	145150852	C	C	145150852	2	2	180	1	0	0	0	0	0	0	0	1	4152	1277	45	2		2	CYC1	8	145150852	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08	35685518	145150852	1213170	60	33874											
TTC39B	158219	broad.mit.edu	37	chr9	15185309	15185309	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatgagcttcacaggtgcaGgtaaggaggcggagtaacgc	12	6	16	7	2	1	2	1	1	0	1	1	4	1	4	0	5	3	4	0	5	2	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr9:15185309G>A	uc003zlr.1	-	16	1506	c.1385C>T	c.(1384-1386)CCT>CTT	p.P462L	TTC39B_uc003zlq.1_Missense_Mutation_p.P431L|TTC39B_uc011lmp.1_Missense_Mutation_p.P363L|TTC39B_uc010mie.1_Missense_Mutation_p.P460L|TTC39B_uc011lmq.1_Missense_Mutation_p.P449L|TTC39B_uc011lmr.1_Missense_Mutation_p.P393L|TTC39B_uc003zlp.1_Missense_Mutation_p.P45L	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	462							binding			ovary(1)	1						CACAGGTGCAGGTAAGGAGGC	0.473													43	102					0	0	0	0	A	15185309	A	A	15185309	3	1	180	1	0	0	0	0	1	0	0	0	16776	1000	35	4	485	4	TTC39B	9	15185309	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08		15185309	126028122	61	33875											
KIAA1797	54914	broad.mit.edu	37	chr9	20981679	20981679	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgacctcctgccaaataaGattcgggtgaggaacaaaaa	15	9	9	8	1	0	3	0	2	0	1	2	4	1	4	3	2	2	0	3	2	5	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr9:20981679G>C	uc003zog.1	+	40	4995	c.4632G>C	c.(4630-4632)AAG>AAC	p.K1544N	KIAA1797_uc003zoh.1_Missense_Mutation_p.K980N	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1544						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		TGCCAAATAAGATTCGGGTGA	0.448													5	48					0	0	0	0	C	20981679	C	C	20981679	3	2	180	1	0	0	0	0	1	0	0	0	8297	933	33	2	4778	2	KIAA1797	9	20981679	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	5796370	20981679	120231752	62	33876											
SEMA4D	10507	broad.mit.edu	37	chr9	91978793	91978793	+	Frame_Shift_Del	DEL	T	-	-																															ccctgccatcgggcagtgcaTgggtctgcacagggacacag																										TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr9:91978793delT	uc011ltm.1	-	19	2527	c.1955delA	c.(1954-1956)CATfs	p.H652fs	SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aql.2_RNA|SEMA4D_uc004aqm.2_RNA	NM_001142287	NP_001135759	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 2	Error:Variant_position_missing_in_Q92854_after_alignment					anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						GGGCAGTGCATGGGTCTGCAC	0.607													---	---	---								-	91978793	-	-	91978793	7	5	180	1	0	1	0	1	0	0	0	0	14099	1464	51	0	273	0	SEMA4D	9	91978793	Frame_Shift_Del	DEL	T	TCGA-CV-5966-01A-11D-1683-08	70997114	91978793	49234638	63	33877											
ABCA1	19	broad.mit.edu	37	chr9	107564419	107564419	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcttgagtattactgacAcccagggaaaagccgccata	13	8	10	10	1	0	2	0	2	0	0	0	3	0	3	3	1	3	2	3	1	5	4			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr9:107564419A>C	uc004bcl.2	-	34	4927	c.4614T>G	c.(4612-4614)GGT>GGG	p.G1538G		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1538	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TATTACTGACACCCAGGGAAA	0.448													8	35					0	0	0	0	C	107564419	C	C	107564419	2	2	180	1	0	0	0	0	0	0	0	1	28	146	6	5		5	ABCA1	9	107564419	Silent	SNP	A	TCGA-CV-5966-01A-11D-1683-08	15585626	107564419	33649012	64	33878											
COL27A1	85301	broad.mit.edu	37	chr9	116930511	116930511	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accctgtgacgcaggtcgctCacaattactgtacccacctg	9	9	8	15	2	1	1	1	1	0	0	2	1	1	1	3	1	2	3	3	1	3	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr9:116930511C>T	uc011lxl.1	+	3	676	c.676C>T	c.(676-678)CAC>TAC	p.H226Y	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.H76Y	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	226	Laminin G-like.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GCAGGTCGCTCACAATTACTG	0.557													24	64					0	0	0	0	T	116930511	T	T	116930511	3	4	180	1	0	0	0	0	1	0	0	0	3700	826	29	2	686	2	COL27A1	9	116930511	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	9366092	116930511	24282920	65	33879											
GOLGA1	2800	broad.mit.edu	37	chr9	127652667	127652667	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcagcgtgaaacagggcccaCctgttgctggaactcttccc	8	9	10	14	1	2	1	1	1	1	0	3	2	3	2	3	2	4	2	3	2	2	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	6ab7e029-9217-48a2-9c7f-dbc4c6963afa	g.chr9:127652667C>A	uc004bpc.2	-	16	1839	c.1497_splice	c.e16+1	p.Q499_splice	GOLGA1_uc010mws.2_Splice_Site	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97							Golgi cisterna membrane				ovary(1)	1						ACAGGGCCCACCTGTTGCTGG	0.597													4	57					0.00909568	0.00932307	1	0	A	127652667	A	A	127652667	5	1	180	1	0	0	0	0	0	0	1	0	6588	521	18	4	837	4	GOLGA1	9	127652667	Splice_Site	SNP	C	TCGA-CV-5966-01A-11D-1683-08	10722156	127652667	13560764	66	33880											
COL5A1	1289	broad.mit.edu	37	chr9	137620520	137620520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcaattcgctttcagtacaCggaaggagacggcgagggtg	10	7	15	9	5	1	1	1	0	0	1	2	4	1	2	0	4	1	3	0	4	3	3	rs148548209		TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr9:137620520C>T	uc004cfe.2	+	6	1173	c.791C>T	c.(790-792)ACG>ATG	p.T264M		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	264	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TTTCAGTACACGGAAGGAGAC	0.612													46	173					0	0	0	0	T	137620520	T	T	137620520	3	4	180	1	0	0	0	0	1	0	0	0	3711	536	19	1	813	1	COL5A1	9	137620520	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	9967853	137620520	3592911	67	33881											
COL5A1	1289	broad.mit.edu	37	chr9	137716559	137716559	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcgagaactacgtggactaCgcggacggcatggaagagat	12	5	16	8	5	0	2	0	0	0	2	0	7	0	5	0	5	3	1	0	5	4	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr9:137716559C>T	uc004cfe.2	+	62	5194	c.4812C>T	c.(4810-4812)TAC>TAT	p.Y1604Y	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1604	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ACGTGGACTACGCGGACGGCA	0.622													12	29					0	0	0	0	T	137716559	T	T	137716559	2	4	180	1	0	0	0	0	0	0	0	1	3711	547	19	1		1	COL5A1	9	137716559	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08	96039	137716559	3496872	68	33882											
NOTCH1	4851	broad.mit.edu	37	chr9	139409935	139409936	+	Frame_Shift_Ins	INS	-	TG	TG																															cacccgcctggccggccaccINStgtggtccccttcaggcaga																										TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr9:139409935_139409936insTG	uc004chz.2	-	11	1902_1903	c.1902_1903insCA	c.(1900-1905)ACAGGAfs	p.T634fs	NOTCH1_uc004cia.1_5'Flank	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	634_635	Extracellular (Potential).|EGF-like 16; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGCCGGCCACCTGTGGTCCCCT	0.698			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								TG	139409936	TG	TG	139409935	7	5	180	1	0	1	1	0	0	0	0	0	10601	695	24	0	5860	0	NOTCH1	9	139409935	Frame_Shift_Ins	INS	-	TCGA-CV-5966-01A-11D-1683-08	1693376	139409935	1803496	69	33883											
ARID5B	84159	broad.mit.edu	37	chr10	63661489	63661489	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggagcccaactcactccaGgtatttcgctctcctccgct	7	11	7	16	2	2	0	1	0	1	0	6	1	4	1	4	2	2	3	4	2	2	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr10:63661489G>A	uc001jlt.1	+	1	47	c.21G>A	c.(19-21)CAG>CAA	p.Q7Q	ARID5B_uc010qil.1_Silent_p.Q7Q	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	7					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					ACTCACTCCAGGTATTTCGCT	0.587													7	32					0	0	0	0	A	63661489	A	A	63661489	2	1	180	1	0	0	0	0	0	0	0	1	922	1014	35	4		4	ARID5B	10	63661489	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08		63661489	71873258	70	33884											
DNA2	1763	broad.mit.edu	37	chr10	70204742	70204742	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agttttctcttcctcaattaTttgtggcaaagaagcaagct	11	15	7	8	0	2	1	1	0	1	1	4	1	3	1	1	1	2	4	1	1	5	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr10:70204742T>C	uc001jof.2	-	8	1414	c.1414A>G	c.(1414-1416)ATA>GTA	p.I472V	DNA2_uc001jog.1_Missense_Mutation_p.I386V|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	386					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						TCCTCAATTATTTGTGGCAAA	0.343													20	44					0	0	0	0	C	70204742	C	C	70204742	3	2	180	1	0	0	0	0	1	0	0	0	4618	1493	52	5	2082	5	DNA2	10	70204742	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	6543253	70204742	65330005	71	33885											
DLG5	9231	broad.mit.edu	37	chr10	79569435	79569435	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagctccagctgggactttTtgatgaagacaacgcgtggc	10	9	12	10	2	0	3	0	2	0	1	1	4	1	4	1	2	3	2	1	2	3	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr10:79569435T>C	uc001jzk.2	-	24	4587	c.4517A>G	c.(4516-4518)AAA>AGA	p.K1506R	DLG5_uc001jzi.2_Missense_Mutation_p.K261R|DLG5_uc001jzj.2_Missense_Mutation_p.K921R|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1506	PDZ 4.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CTGGGACTTTTTGATGAAGAC	0.542													70	162					0	0	0	0	C	79569435	C	C	79569435	3	2	180	1	0	0	0	0	1	0	0	0	4580	1841	64	5	1278	5	DLG5	10	79569435	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	9364693	79569435	55965312	72	33886											
GRID1	2894	broad.mit.edu	37	chr10	87615919	87615919	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggcgttggccagcatcagaAcactgtcatacagatagagg	13	7	12	9	1	2	3	2	0	0	3	2	3	2	3	1	3	3	2	1	3	3	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr10:87615919A>G	uc001kdl.1	-	7	1081	c.980T>C	c.(979-981)GTT>GCT	p.V327A	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	327	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CAGCATCAGAACACTGTCATA	0.498										Multiple Myeloma(13;0.14)			18	36					0	0	0	0	G	87615919	G	G	87615919	3	3	180	1	0	0	0	0	1	0	0	0	6810	43	2	5	2089	5	GRID1	10	87615919	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	8046484	87615919	47918828	73	33887											
ATRNL1	26033	broad.mit.edu	37	chr10	117704198	117704198	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgccagtgccctaatagatAtttcacaacagaaagcttca	14	11	6	10	0	2	2	2	0	0	2	2	2	2	2	2	0	4	1	2	0	5	6			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr10:117704198A>G	uc001lcg.2	+	29	4434	c.4048A>G	c.(4048-4050)ATT>GTT	p.I1350V	ATRNL1_uc010qsm.1_Missense_Mutation_p.I479V|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1350	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CCTAATAGATATTTCACAACA	0.423													22	49					0	0	0	0	G	117704198	G	G	117704198	3	3	180	1	0	0	0	0	1	0	0	0	1209	449	16	5	4162	5	ATRNL1	10	117704198	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	30088279	117704198	17830549	74	33888											
DCHS1	8642	broad.mit.edu	37	chr11	6662135	6662135	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcacgtccagcagggcctggGccctccgggggggtgaacca	6	5	16	14	2	1	1	1	1	0	0	3	1	3	1	5	5	2	1	5	5	1	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr11:6662135G>T	uc001mem.1	-	2	1120	c.710C>A	c.(709-711)GCC>GAC	p.A237D		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	237	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGGCCTGGGCCCTCCGGGG	0.597													25	115					1.42536e-11	1.54972e-11	1	0	T	6662135	T	T	6662135	3	4	180	1	0	0	0	0	1	0	0	0	4304	1203	42	4	9266	4	DCHS1	11	6662135	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08		6662135	128344381	75	33889											
ST5	6764	broad.mit.edu	37	chr11	8728695	8728695	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccctggggctgggaagggCgactccatgagacttctcat	7	10	13	11	1	1	1	1	1	1	1	4	4	3	2	2	4	0	1	2	4	1	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr11:8728695C>T	uc001mgt.2	-	13	2694	c.2508G>A	c.(2506-2508)TCG>TCA	p.S836S	ST5_uc009yfr.2_Silent_p.S416S|ST5_uc001mgu.2_Silent_p.S416S|ST5_uc001mgv.2_Silent_p.S836S|ST5_uc010rbq.1_RNA|ST5_uc010rbp.1_Silent_p.S349S|ST5_uc009yfs.2_RNA	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	836	DENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CTGGGAAGGGCGACTCCATGA	0.592													11	33					0	0	0	0	T	8728695	T	T	8728695	2	4	180	1	0	0	0	0	0	0	0	1	15286	755	27	1		1	ST5	11	8728695	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08	2066560	8728695	126277821	76	33890											
CSRP3	8048	broad.mit.edu	37	chr11	19209725	19209725	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcgcccgtgtctgtgctgAgacagccagcgccttgtcca	5	9	12	15	3	1	1	0	1	1	1	3	2	2	1	4	0	3	2	4	0	0	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr11:19209725A>T	uc001mpk.2	-	3	356	c.239T>A	c.(238-240)CTC>CAC	p.L80H		NM_003476	NP_003467	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3	80					cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding				0						GTCTGTGCTGAGACAGCCAGC	0.567													18	97					0	0	0	0	T	19209725	T	T	19209725	3	4	180	1	0	0	0	0	1	0	0	0	3986	304	11	5	361	5	CSRP3	11	19209725	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	10481030	19209725	115796791	77	33891											
HIPK3	10114	broad.mit.edu	37	chr11	33308310	33308310	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgtggcgaaacagattgcAtttcctagaaggcccccagc	10	7	12	12	2	0	2	0	0	0	2	1	3	1	2	3	3	3	1	3	3	3	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr11:33308310A>G	uc001mul.1	+	2	620	c.350A>G	c.(349-351)CAT>CGT	p.H117R	HIPK3_uc001mum.1_Missense_Mutation_p.H117R|HIPK3_uc009yjv.1_Missense_Mutation_p.H117R	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	117					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						AACAGATTGCATTTCCTAGAA	0.498													11	39					0	0	0	0	G	33308310	G	G	33308310	3	3	180	1	0	0	0	0	1	0	0	0	7157	217	8	5	352	5	HIPK3	11	33308310	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	14098585	33308310	101698206	78	33892											
ALKBH3	221120	broad.mit.edu	37	chr11	43923092	43923092	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgtgctgcgcacactaaaGaaccgcattgaagagaacac	14	6	9	12	2	0	3	0	1	0	2	0	4	0	3	2	0	4	3	2	0	5	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr11:43923092G>C	uc001mxs.2	+	8	929	c.486G>C	c.(484-486)AAG>AAC	p.K162N	ALKBH3_uc009ykp.2_RNA|ALKBH3_uc001mxt.2_RNA|ALKBH3_uc009ykq.2_Missense_Mutation_p.K15N	NM_139178	NP_631917	Q96Q83	ALKB3_HUMAN	AlkB homolog 3	162					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation	mitochondrion|nucleoplasm	damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	GCACACTAAAGAACCGCATTG	0.488								Direct_reversal_of_damage					11	32					0	0	0	0	C	43923092	C	C	43923092	3	2	180	1	0	0	0	0	1	0	0	0	528	933	33	2	512	2	ALKBH3	11	43923092	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	10614782	43923092	91083424	79	33893											
NUMA1	4926	broad.mit.edu	37	chr11	71717271	71717271	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagaccgcgtgctgtagaaCgatgagttggcgctgtctgg	7	9	16	9	4	1	3	0	1	1	2	1	4	1	3	1	2	2	5	1	2	2	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr11:71717271C>T	uc001orl.1	-	22	5674	c.5502G>A	c.(5500-5502)TCG>TCA	p.S1834S	NUMA1_uc001orj.2_Silent_p.S16S|NUMA1_uc009ysw.1_Silent_p.S1401S|NUMA1_uc001ork.1_Silent_p.S698S|NUMA1_uc001orm.1_Silent_p.S1820S	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1834					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						TGCTGTAGAACGATGAGTTGG	0.552			T	RARA	APL								6	56					0	0	0	0	T	71717271	T	T	71717271	2	4	180	1	0	0	0	0	0	0	0	1	10804	523	19	1		1	NUMA1	11	71717271	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08	27794179	71717271	63289245	80	33894											
PRDM10	56980	broad.mit.edu	37	chr11	129827743	129827743	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tacaccacctgctgtgggggGcgaacctggtcatcggtata	8	9	13	11	2	1	0	1	0	0	0	2	1	1	0	3	5	3	2	3	5	4	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr11:129827743G>A	uc001qfm.2	-	3	364	c.132C>T	c.(130-132)CGC>CGT	p.R44R	PRDM10_uc001qfn.2_Silent_p.R44R|PRDM10_uc009zct.1_Silent_p.R44R	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	44					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		GCTGTGGGGGGCGAACCTGGT	0.537													51	182					0	0	0	0	A	129827743	A	A	129827743	2	1	180	1	0	0	0	0	0	0	0	1	12513	1190	42	4		4	PRDM10	11	129827743	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08	58110472	129827743	5178773	81	33895											
LRRK2	120892	broad.mit.edu	37	chr12	40715964	40715964	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagtttcttaaaaattacAgttccttcttgtagaaaagg	14	14	8	5	0	2	2	0	0	2	2	3	3	3	2	1	1	1	3	1	1	7	7			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr12:40715964A>T	uc001rmg.3	+	36	5419	c.5298A>T	c.(5296-5298)ACA>ACT	p.T1766T	LRRK2_uc009zjw.2_Silent_p.T604T|LRRK2_uc001rmi.2_Silent_p.T599T	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1766					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TAAAAATTACAGTTCCTTCTT	0.303													9	35					0	0	0	0	T	40715964	T	T	40715964	2	4	180	1	0	0	0	0	0	0	0	1	9083	175	7	5		5	LRRK2	12	40715964	Silent	SNP	A	TCGA-CV-5966-01A-11D-1683-08		40715964	93135931	82	33896											
ITGA7	3679	broad.mit.edu	37	chr12	56091493	56091493	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcacctgaagagcactgcGgtgtcagccagggagcccac	9	5	13	14	1	2	2	2	1	0	1	2	3	2	3	3	2	4	2	3	2	1	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr12:56091493G>A	uc001shh.2	-	9	1627	c.1407C>T	c.(1405-1407)ACC>ACT	p.T469T	ITGA7_uc001shg.2_Silent_p.T465T|ITGA7_uc010sps.1_Silent_p.T372T|ITGA7_uc009znw.2_5'Flank|ITGA7_uc009znx.2_Silent_p.T352T	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	509	FG-GAP 7.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						AGAGCACTGCGGTGTCAGCCA	0.597													19	53					0	0	0	0	A	56091493	A	A	56091493	2	1	180	1	0	0	0	0	0	0	0	1	7920	1103	39	1		1	ITGA7	12	56091493	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08	15375529	56091493	77760402	83	33897											
CCDC60	160777	broad.mit.edu	37	chr12	119917004	119917004	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcgctaaccgaggctcaCgtgtaagtagtctcacctcc	8	9	8	16	3	2	0	2	0	1	0	5	1	3	0	4	1	1	4	4	1	3	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr12:119917004C>G	uc001txe.2	+	4	912	c.447C>G	c.(445-447)CAC>CAG	p.H149Q	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	149										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CCGAGGCTCACGTGTAAGTAG	0.478													5	28					0	0	0	0	G	119917004	G	G	119917004	3	3	180	1	0	0	0	0	1	0	0	0	2844	535	19	3	461	3	CCDC60	12	119917004	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	63825511	119917004	13934891	84	33898											
WDR66	144406	broad.mit.edu	37	chr12	122369654	122369654	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgcccttgtcttccagacCatgacctggtcgtttggatg	5	15	10	11	1	1	2	0	1	1	1	3	3	2	3	4	2	1	1	4	2	0	4			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr12:122369654C>T	uc009zxk.2	+	4	892	c.750C>T	c.(748-750)ACC>ACT	p.T250T		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	250							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		TCTTCCAGACCATGACCTGGT	0.502													3	25					0	0	0	0	T	122369654	T	T	122369654	2	4	180	1	0	0	0	0	0	0	0	1	17385	581	21	4		4	WDR66	12	122369654	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08	2452650	122369654	11482241	85	33899											
DNAH10	196385	broad.mit.edu	37	chr12	124371815	124371815	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgttcacggatgcccatgtgGctgaggagggcttcctggag	6	10	16	9	1	1	1	1	1	0	0	2	4	2	4	2	5	1	3	2	5	0	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr12:124371815G>A	uc001uft.3	+	51	8621	c.8596G>A	c.(8596-8598)GCT>ACT	p.A2866T		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2866	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGCCCATGTGGCTGAGGAGGG	0.542													6	30					0	0	0	0	A	124371815	A	A	124371815	3	1	180	1	0	0	0	0	1	0	0	0	4620	1203	42	4	8798	4	DNAH10	12	124371815	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	2002161	124371815	9480080	86	33900											
CKAP2	26586	broad.mit.edu	37	chr13	53048164	53048164	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttaaaacccccaatacagaaAcgaggacaagttgcttaatt	17	9	6	9	1	0	1	0	0	0	1	0	3	0	2	2	1	4	2	2	1	7	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr13:53048164A>G	uc001vgv.2	+	8	1947	c.1750A>G	c.(1750-1752)ACG>GCG	p.T584A	CKAP2_uc001vgu.2_Missense_Mutation_p.T583A|CKAP2_uc010tha.1_Missense_Mutation_p.T535A	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	584					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		CAATACAGAAACGAGGACAAG	0.328													12	43					0	0	0	0	G	53048164	G	G	53048164	3	3	180	1	0	0	0	0	1	0	0	0	3457	43	2	5	1780	5	CKAP2	13	53048164	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08		53048164	62121714	87	33901											
DACH1	1602	broad.mit.edu	37	chr13	72440352	72440352	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattttgcactcattattctGaggggtgttttccactgggg	6	16	11	8	0	2	1	1	1	1	0	3	1	3	1	1	4	1	2	1	4	1	6			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr13:72440352G>A	uc010thn.1	-	2	973	c.550C>T	c.(550-552)CAG>TAG	p.Q184*	DACH1_uc010tho.1_Nonsense_Mutation_p.Q184*|DACH1_uc010thp.1_Nonsense_Mutation_p.Q184*	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	184					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TCATTATTCTGAGGGGTGTTT	0.488													7	21					0	0	0	0	A	72440352	A	A	72440352	4	1	180	1	0	0	0	0	0	1	0	0	4237	1299	45	2	1614	2	DACH1	13	72440352	Nonsense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	19392188	72440352	42729526	88	33902											
MYCBP2	23077	broad.mit.edu	37	chr13	77625998	77625998	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaatgagctctctgggatcaTaatcatctccccgtccagcc	10	10	7	14	1	4	1	2	1	2	0	7	2	5	2	4	1	2	1	4	1	2	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr13:77625998T>C	uc001vkf.2	-	82	13680	c.13589A>G	c.(13588-13590)TAT>TGT	p.Y4530C	MYCBP2_uc010aev.2_Missense_Mutation_p.Y3934C|MYCBP2_uc001vke.2_Missense_Mutation_p.Y1147C	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4530					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TCTGGGATCATAATCATCTCC	0.428													7	22					0	0	0	0	C	77625998	C	C	77625998	3	2	180	1	0	0	0	0	1	0	0	0	10071	1406	49	5	345	5	MYCBP2	13	77625998	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	5185646	77625998	37543880	89	33903											
MYCBP2	23077	broad.mit.edu	37	chr13	77672743	77672743	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtacttttttgaggtagaTttttatcatgtggtgaggag	9	17	12	3	0	1	3	1	2	0	1	1	4	1	4	0	3	1	2	0	3	3	8			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr13:77672743T>C	uc001vkf.2	-	57	8523	c.8432A>G	c.(8431-8433)AAT>AGT	p.N2811S	MYCBP2_uc010aev.2_Missense_Mutation_p.N2215S|MYCBP2_uc001vkg.1_Missense_Mutation_p.N334S|MYCBP2_uc010aew.2_Missense_Mutation_p.N197S	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2811					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTGAGGTAGATTTTTATCATG	0.483													22	56					0	0	0	0	C	77672743	C	C	77672743	3	2	180	1	0	0	0	0	1	0	0	0	10071	1493	52	5	5602	5	MYCBP2	13	77672743	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	46745	77672743	37497135	90	33904											
SPRY2	10253	broad.mit.edu	37	chr13	80911560	80911560	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggacctgcgagtgctggAgcctaggaggctggcggtgc	7	7	18	9	2	0	0	0	0	0	0	0	4	0	3	2	6	4	2	2	6	2	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr13:80911560A>C	uc001vli.2	-	2	1259	c.281T>G	c.(280-282)CTC>CGC	p.L94R	SPRY2_uc001vlj.2_Missense_Mutation_p.L94R	NM_005842	NP_005833	O43597	SPY2_HUMAN	sprouty 2	94					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			ovary(1)|lung(1)	2	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		CGAGTGCTGGAGCCTAGGAGG	0.622													17	62					0	0	0	0	C	80911560	C	C	80911560	3	2	180	1	0	0	0	0	1	0	0	0	15172	304	11	5	670	5	SPRY2	13	80911560	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	3238817	80911560	34258318	91	33905											
OR4N5	390437	broad.mit.edu	37	chr14	20612330	20612330	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagcctgctatgcattatcgTtggttctgtggcttgggggc	4	14	15	8	1	1	0	0	0	1	0	2	1	1	0	1	4	3	5	1	4	2	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr14:20612330T>C	uc010tla.1	+	1	436	c.436T>C	c.(436-438)TTG>CTG	p.L146L		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TGCATTATCGTTGGTTCTGTG	0.498													12	117					0	0	0	0	C	20612330	C	C	20612330	2	2	180	1	0	0	0	0	0	0	0	1	11133	1722	60	5		5	OR4N5	14	20612330	Silent	SNP	T	TCGA-CV-5966-01A-11D-1683-08		20612330	86737210	92	33906											
FNTB	2342	broad.mit.edu	37	chr14	65390788	65390788	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtaagcgggattttatgcTgatcacaaacaaatccttga	14	11	8	8	1	1	2	1	2	0	0	2	3	2	3	1	1	3	2	1	1	4	4			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr14:65390788T>C	uc010tsl.1	+	2	193	c.119T>C	c.(118-120)CTG>CCG	p.L40P	CHURC1_uc010tsj.1_Missense_Mutation_p.L40P|CHURC1_uc010tsk.1_RNA|FNTB_uc010tsm.1_5'UTR|CHURC1_uc001xhv.1_Missense_Mutation_p.L40P|CHURC1_uc001xhw.1_Missense_Mutation_p.L40P	NM_002028	NP_002019	P49356	FNTB_HUMAN	farnesyltransferase, CAAX box, beta	Error:Variant_position_missing_in_P49356_after_alignment					protein farnesylation	microtubule associated complex	protein binding|protein farnesyltransferase activity			ovary(1)	1				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		GATTTTATGCTGATCACAAAC	0.383													14	63					0	0	0	0	C	65390788	C	C	65390788	3	2	180	1	0	0	0	0	1	0	0	0	6010	1580	55	5		5	FNTB	14	65390788	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	44778458	65390788	41958752	93	33907											
C16orf11	146325	broad.mit.edu	37	chr16	614994	614994	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agacgcacccctcgacctctCtgtgaaacgtgcgcccgcca	8	6	9	18	5	1	2	0	1	1	1	3	3	1	2	5	0	2	1	5	0	1	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr16:614994C>G	uc002chk.2	+	3	1682	c.1403C>G	c.(1402-1404)TCT>TGT	p.S468C	NHLRC4_uc002chl.2_5'Flank|PIGQ_uc010bqw.2_5'Flank	NM_145270	NP_660313	P0CG20	CP011_HUMAN	hypothetical protein LOC146325	468										central_nervous_system(1)	1						CTCGACCTCTCTGTGAAACGT	0.726													3	13					0	0	0	0	G	614994	G	G	614994	3	3	180	1	0	0	0	0	1	0	0	0	1816	913	32	2	1409	2	C16orf11	16	614994	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08		614994	89739759	94	33908											
USP31	57478	broad.mit.edu	37	chr16	23117549	23117549	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttaccttgtgtggggcagaGgaattggcaaagaaatgcaa	13	9	13	6	0	0	2	0	0	0	2	0	3	0	3	1	4	2	3	1	4	5	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr16:23117549G>A	uc002dll.2	-	4	938	c.938C>T	c.(937-939)CCT>CTT	p.P313L		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	313					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		GTGGGGCAGAGGAATTGGCAA	0.388													9	46					0	0	0	0	A	23117549	A	A	23117549	3	1	180	1	0	0	0	0	1	0	0	0	17130	1000	35	4	3172	4	USP31	16	23117549	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	22502555	23117549	67237204	95	33909											
TAOK2	9344	broad.mit.edu	37	chr16	30002109	30002109	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttcatcttccccagctgcGgcttgatgagacccaggagg	7	10	12	12	1	2	2	1	2	1	1	3	4	3	3	3	3	2	3	3	3	0	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr16:30002109G>A	uc002dvc.1	+	18	3233	c.2450G>A	c.(2449-2451)CGG>CAG	p.R817Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron	NM_004783	NP_004774	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CCCCAGCTGCGGCTTGATGAG	0.592													18	48					0	0	0	0	A	30002109	A	A	30002109	3	1	180	1	0	0	0	0	1	0	0	0	15614	1116	39	1	3992	1	TAOK2	16	30002109	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	6884560	30002109	60352644	96	33910											
CHD9	80205	broad.mit.edu	37	chr16	53289642	53289642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagattttactacgtcgtaCaaaaactattacaattgaat	16	14	4	7	2	1	2	1	1	0	1	2	2	1	2	0	0	5	1	0	0	9	7			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr16:53289642C>T	uc002ehb.2	+	18	4324	c.4160C>T	c.(4159-4161)ACA>ATA	p.T1387I	CHD9_uc002egy.2_Missense_Mutation_p.T1387I|CHD9_uc002ehc.2_Missense_Mutation_p.T1387I|CHD9_uc002ehf.2_Missense_Mutation_p.T501I|CHD9_uc002ehd.2_Missense_Mutation_p.T913I	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1387					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CTACGTCGTACAAAAACTATT	0.393													21	197					0	0	0	0	T	53289642	T	T	53289642	3	4	180	1	0	0	0	0	1	0	0	0	3347	478	17	4	4230	4	CHD9	16	53289642	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	23287533	53289642	37065111	97	33911											
HERPUD1	9709	broad.mit.edu	37	chr16	56974084	56974084	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctacattttctgtttttCtcagtatcctctacttctac	7	19	3	12	0	4	0	1	0	4	0	6	0	5	0	1	0	4	3	1	0	4	9			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr16:56974084C>T	uc002eke.1	+	6	1241	c.832C>T	c.(832-834)CTC>TTC	p.L278F	HERPUD1_uc002ekf.1_Missense_Mutation_p.L277F|HERPUD1_uc002ekg.1_Missense_Mutation_p.L253F|HERPUD1_uc010cco.1_Intron|HERPUD1_uc010ccp.1_Intron|HERPUD1_uc002ekh.1_Missense_Mutation_p.L96F	NM_014685	NP_055500	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum	278	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0						TTCTGTTTTTCTCAGTATCCT	0.433			T	ERG	prostate								81	70					0	0	0	0	T	56974084	T	T	56974084	3	4	180	1	0	0	0	0	1	0	0	0	7102	913	32	2	854	2	HERPUD1	16	56974084	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	3684442	56974084	33380669	98	33912											
FAM192A	80011	broad.mit.edu	37	chr16	57188404	57188404	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggaggtgtttccgagagacTtgcaggatgagggctctgca	8	9	17	7	1	1	2	0	1	1	1	2	6	2	4	1	4	2	4	1	4	0	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr16:57188404T>G	uc010vhk.1	-	7	822	c.563A>C	c.(562-564)AAG>ACG	p.K188T	FAM192A_uc002ekz.3_Missense_Mutation_p.K187T|FAM192A_uc002ekv.3_Missense_Mutation_p.K110T|FAM192A_uc002ekw.3_Missense_Mutation_p.K187T|FAM192A_uc002ekx.3_Missense_Mutation_p.K187T|FAM192A_uc002eky.3_Missense_Mutation_p.K187T	NM_024946	NP_079222	Q9GZU8	F192A_HUMAN	NEFA-interacting nuclear protein NIP30	188						nucleus					0						TCCGAGAGACTTGCAGGATGA	0.488													8	35					0	0	0	0	G	57188404	G	G	57188404	3	3	180	1	0	0	0	0	1	0	0	0	5551	1609	56	5	205	5	FAM192A	16	57188404	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	214320	57188404	33166349	99	33913											
CDH3	1001	broad.mit.edu	37	chr16	68712178	68712178	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttcccccagagactgaatCaggtacgactgtgccttctc	8	10	8	15	1	2	2	1	1	1	1	4	4	3	2	4	1	2	1	4	1	2	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr16:68712178C>G	uc002ewf.2	+	4	1520	c.388C>G	c.(388-390)CAG>GAG	p.Q130E	CDH3_uc010vli.1_Missense_Mutation_p.Q75E	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	130	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		GAGACTGAATCAGGTACGACT	0.527													9	34					0	0	0	0	G	68712178	G	G	68712178	3	3	180	1	0	0	0	0	1	0	0	0	3126	827	29	2	402	2	CDH3	16	68712178	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	11523774	68712178	21642575	100	33914											
RAP1GAP2	23108	broad.mit.edu	37	chr17	2867251	2867251	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcaccccaacatcgctgggGagcagcatctgtgaggagga	10	5	15	11	1	1	1	0	1	1	0	2	4	1	4	2	5	3	4	2	5	1	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr17:2867251G>C	uc010ckd.2	+	7	471	c.381G>C	c.(379-381)GGG>GGC	p.G127G	RAP1GAP2_uc010cke.2_Silent_p.G112G	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	127					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						CATCGCTGGGGAGCAGCATCT	0.602													11	35					0	0	0	0	C	2867251	C	C	2867251	2	2	180	1	0	0	0	0	0	0	0	1	13103	1161	41	2		2	RAP1GAP2	17	2867251	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08		2867251	78327959	101	33915											
TP53	7157	broad.mit.edu	37	chr17	7578479	7578479	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gacgcgggtgccgggcggggGtgtggaatcaacccacagct	7	5	18	11	4	1	0	1	0	0	0	1	2	1	1	2	5	3	1	2	5	2	0	rs28934874		TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr17:7578479G>T	uc002gim.2	-	5	645	c.451C>A	c.(451-453)CCC>ACC	p.P151T	TP53_uc002gig.1_Missense_Mutation_p.P151T|TP53_uc002gih.2_Missense_Mutation_p.P151T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P19T|TP53_uc010cng.1_Missense_Mutation_p.P19T|TP53_uc002gii.1_Missense_Mutation_p.P19T|TP53_uc010cnh.1_Missense_Mutation_p.P151T|TP53_uc010cni.1_Missense_Mutation_p.P151T|TP53_uc002gij.2_Missense_Mutation_p.P151T|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P58T|TP53_uc002gio.2_Missense_Mutation_p.P19T|TP53_uc010vug.1_Missense_Mutation_p.P112T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	151	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.P151H(25)|p.P151T(13)|p.P151P(12)|p.P151A(10)|p.P152fs*18(9)|p.0?(7)|p.P151fs*30(7)|p.P151L(6)|p.P151R(6)|p.T150fs*16(3)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P58A(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P19A(1)|p.P152fs*14(1)|p.T150_P151delTP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGGCGGGGGTGTGGAATCA	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	33					3.65163e-15	4.07975e-15	1	0	T	7578479	T	T	7578479	3	4	180	1	0	0	0	0	1	0	0	0	16448	1261	44	4	847	4	TP53	17	7578479	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	4711228	7578479	73616731	102	33916											
SLC47A2	146802	broad.mit.edu	37	chr17	19605988	19605988	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaccagggcaatgacatctCtgcagaagaaatgagaaagc	16	6	10	9	0	2	4	1	2	1	3	3	5	2	4	1	1	2	2	1	1	4	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr17:19605988C>G	uc002gwe.3	-	13	1378	c.1203_splice	c.e13-1	p.E401_splice	SLC47A2_uc002gwg.3_Splice_Site_p.E365_splice|SLC47A2_uc002gwf.3_Splice_Site_p.E379_splice|SLC47A2_uc002gwh.3_Splice_Site|SLC47A2_uc002gwi.2_Splice_Site|SLC47A2_uc010cqs.1_Splice_Site	NM_152908	NP_690872	Q86VL8	S47A2_HUMAN	solute carrier family 47, member 2 isoform 1							integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					AATGACATCTCTGCAGAAGAA	0.453													6	13					0	0	0	0	G	19605988	G	G	19605988	5	3	180	1	0	0	0	0	0	0	1	0	14712	927	32	2	626	2	SLC47A2	17	19605988	Splice_Site	SNP	C	TCGA-CV-5966-01A-11D-1683-08	12027509	19605988	61589222	103	33917											
ADCYAP1	116	broad.mit.edu	37	chr18	909585	909585	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggcggccgtcctagggaaGaggtataaacaaagggttaa	13	8	14	6	2	0	1	0	0	0	1	1	2	1	2	2	5	1	2	2	5	7	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr18:909585G>C	uc010dkg.2	+	5	599	c.480G>C	c.(478-480)AAG>AAC	p.K160N	ADCYAP1_uc010dkh.2_Missense_Mutation_p.K160N	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	160					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						TCCTAGGGAAGAGGTATAAAC	0.507													13	194					0	0	0	0	C	909585	C	C	909585	3	2	180	1	0	0	0	0	1	0	0	0	302	933	33	2	494	2	ADCYAP1	18	909585	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08		909585	77167663	104	33918											
ANKRD12	23253	broad.mit.edu	37	chr18	9257171	9257171	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaattataagcgaggggagAcctaccatagaagttcgaag	15	8	11	7	2	0	2	0	0	0	2	1	5	0	2	2	2	2	1	2	2	7	6			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr18:9257171A>G	uc002knv.2	+	9	4163	c.3906A>G	c.(3904-3906)AGA>AGG	p.R1302R	ANKRD12_uc002knw.2_Silent_p.R1279R|ANKRD12_uc002knx.2_Silent_p.R1279R|ANKRD12_uc010dkx.1_Silent_p.R1009R	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1302						nucleus				ovary(2)|central_nervous_system(1)	3						GCGAGGGGAGACCTACCATAG	0.398													50	70					0	0	0	0	G	9257171	G	G	9257171	2	3	180	1	0	0	0	0	0	0	0	1	640	272	10	5		5	ANKRD12	18	9257171	Silent	SNP	A	TCGA-CV-5966-01A-11D-1683-08	8347586	9257171	68820077	105	33919											
MIB1	57534	broad.mit.edu	37	chr18	19424087	19424087	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgccaagcttgatattcAggataaggatggggatactc	12	10	13	6	0	1	1	1	1	0	0	2	4	1	4	1	5	3	1	1	5	4	5			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr18:19424087A>T	uc002ktq.2	+	15	2084	c.2084A>T	c.(2083-2085)CAG>CTG	p.Q695L	MIB1_uc002ktp.2_Missense_Mutation_p.Q334L	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	695					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			CTTGATATTCAGGATAAGGAT	0.433													7	63					0	0	0	0	T	19424087	T	T	19424087	3	4	180	1	0	0	0	0	1	0	0	0	9619	188	7	5	2142	5	MIB1	18	19424087	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	10166916	19424087	58653161	106	33920											
KIAA0427	9811	broad.mit.edu	37	chr18	46238063	46238063	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgcaggaggagaaatgatcGaaggtaggagagacttcgtc	13	6	15	7	3	0	3	0	1	0	2	3	8	0	5	1	4	0	2	1	4	3	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr18:46238063G>A	uc002ldc.2	+	7	866	c.581G>A	c.(580-582)CGA>CAA	p.R194Q	KIAA0427_uc002ldd.2_Missense_Mutation_p.R194Q	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	194	Interaction with NCBP1/CBP80.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding				0						AGAAATGATCGAAGGTAGGAG	0.547											OREG0024973	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	71					0	0	0	0	A	46238063	A	A	46238063	3	1	180	1	0	0	0	0	1	0	0	0	8215	1058	37	1	603	1	KIAA0427	18	46238063	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	26813976	46238063	31839185	107	33921											
WDR18	57418	broad.mit.edu	37	chr19	985937	985937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcacccaatggtctctacGtcctggcaggagttgcagaa	10	9	10	12	1	2	1	1	0	1	1	4	2	3	2	2	3	2	3	2	3	3	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr19:985937G>A	uc002lqm.1	+	2	309	c.283G>A	c.(283-285)GTC>ATC	p.V95I	WDR18_uc002lqn.1_RNA|WDR18_uc010drx.1_Intron|WDR18_uc010dry.1_Missense_Mutation_p.V95I	NM_024100	NP_077005	Q9BV38	WDR18_HUMAN	WD repeat domain 18	95	WD 2.									skin(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGTCTCTACGTCCTGGCAGG	0.572													4	37					0	0	0	0	A	985937	A	A	985937	3	1	180	1	0	0	0	0	1	0	0	0	17346	1145	40	1	289	1	WDR18	19	985937	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08		985937	58143046	108	33922											
C19orf35	374872	broad.mit.edu	37	chr19	2276476	2276476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggtggggcacgtccgcccCgggcttgggcacctgcaagg	4	5	18	14	4	0	0	0	0	0	0	1	0	1	0	4	6	1	4	4	6	1	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr19:2276476C>T	uc002lvn.2	-	4	725	c.625G>A	c.(625-627)GGG>AGG	p.G209R	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	209										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGTCCGCCCCGGGCTTGGGC	0.701													5	11					0	0	0	0	T	2276476	T	T	2276476	3	4	180	1	0	0	0	0	1	0	0	0	1929	652	23	1	800	1	C19orf35	19	2276476	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	1290539	2276476	56852507	109	33923											
PEX11G	92960	broad.mit.edu	37	chr19	7550795	7550795	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagagtcgcaagatggtccTgcagtggctgagttgggtgg	9	9	17	6	1	0	3	0	1	0	2	2	3	1	3	1	4	1	4	1	4	2	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr19:7550795T>A	uc002mgk.1	-	2	187	c.178A>T	c.(178-180)AGG>TGG	p.R60W	PEX11G_uc002mgl.1_5'UTR	NM_080662	NP_542393	Q96HA9	PX11C_HUMAN	peroxisomal biogenesis factor 11 gamma	60	Cytoplasmic (Potential).					integral to membrane|peroxisomal membrane					0						AAGATGGTCCTGCAGTGGCTG	0.567													17	42					0	0	0	0	A	7550795	A	A	7550795	3	1	180	1	0	0	0	0	1	0	0	0	11794	1579	55	5	563	5	PEX11G	19	7550795	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	5274319	7550795	51578188	110	33924											
EVI5L	115704	broad.mit.edu	37	chr19	7916349	7916349	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccagacctcaacacccacttCcgttcccaaagcttccacac	11	7	3	20	1	1	1	1	0	0	1	4	1	4	1	6	0	2	2	6	0	2	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr19:7916349C>T	uc002min.2	+	7	937	c.783C>T	c.(781-783)TTC>TTT	p.F261F	EVI5L_uc010xjz.1_Silent_p.F261F|EVI5L_uc002mio.1_5'UTR	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	261	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						ACACCCACTTCCGTTCCCAAA	0.632													11	68					0	0	0	0	T	7916349	T	T	7916349	2	4	180	1	0	0	0	0	0	0	0	1	5314	854	30	2		2	EVI5L	19	7916349	Silent	SNP	C	TCGA-CV-5966-01A-11D-1683-08	365554	7916349	51212634	111	33925											
ZNF737	100129842	broad.mit.edu	37	chr19	20728770	20728770	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaaagatctcgggcaaaaTgagaacacgtaactgaaaga	18	5	10	8	2	1	4	0	2	1	3	2	5	1	4	1	1	2	2	1	1	6	1	rs61742876	by1000genomes	TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr19:20728770T>G	uc002npa.2	-	4	419	c.239A>C	c.(238-240)CAT>CCT	p.H80P		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	80					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TCGGGCAAAATGAGAACACGT	0.323													4	19					0	0	0	0	G	20728770	G	G	20728770	3	3	180	1	0	0	0	0	1	0	0	0	18193	1464	51	5	1375	5	ZNF737	19	20728770	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	12812421	20728770	38400213	112	33926											
RBM42	79171	broad.mit.edu	37	chr19	36124784	36124784	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctggccatgccattgcccGagcctgagcccctgcccctc	4	7	9	21	1	0	1	0	1	0	0	1	2	0	1	9	1	5	0	9	1	0	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr19:36124784G>A	uc002oan.2	+	7	956	c.880G>A	c.(880-882)GAG>AAG	p.E294K	RBM42_uc010eef.2_Missense_Mutation_p.E240K|RBM42_uc002oao.2_Missense_Mutation_p.E272K|RBM42_uc002oap.2_Missense_Mutation_p.E264K|RBM42_uc002oaq.2_Missense_Mutation_p.E265K|RBM42_uc010eeg.2_Missense_Mutation_p.E265K	NM_024321	NP_077297	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	294	Necessary for interaction with HNRNPK (By similarity).|Pro-rich.					cytoplasm|nucleus	nucleotide binding|RNA binding				0	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCCATTGCCCGAGCCTGAGCC	0.746													4	8					0	0	0	0	A	36124784	A	A	36124784	3	1	180	1	0	0	0	0	1	0	0	0	13201	1059	37	1	906	1	RBM42	19	36124784	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	15396014	36124784	23004199	113	33927											
ZNF527	84503	broad.mit.edu	37	chr19	37879538	37879538	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtacataaatttgatatttAtgataaactcttcccccaaa	16	14	3	8	0	1	2	0	2	1	0	2	2	2	2	2	0	2	1	2	0	8	8			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr19:37879538A>T	uc010efk.1	+	5	698	c.587A>T	c.(586-588)TAT>TTT	p.Y196F	ZNF527_uc002ogf.3_Missense_Mutation_p.Y164F|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTGATATTTATGATAAACTC	0.323													7	68					0	0	0	0	T	37879538	T	T	37879538	3	4	180	1	0	0	0	0	1	0	0	0	18035	449	16	5	601	5	ZNF527	19	37879538	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	1754754	37879538	21249445	114	33928											
ZNF320	162967	broad.mit.edu	37	chr19	53384668	53384668	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttctctccagtatgactTctatgatgacatgcaagggt	9	14	10	8	0	2	3	0	3	2	0	4	3	3	3	1	2	1	3	1	2	3	4			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr19:53384668T>A	uc002qag.2	-	4	902	c.711A>T	c.(709-711)AGA>AGT	p.R237S	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.R183S|ZNF320_uc002qai.2_Missense_Mutation_p.R237S	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	237	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		CAGTATGACTTCTATGATGAC	0.398													10	66					0	0	0	0	A	53384668	A	A	53384668	3	1	180	1	0	0	0	0	1	0	0	0	17906	1780	62	5	822	5	ZNF320	19	53384668	Missense_Mutation	SNP	T	TCGA-CV-5966-01A-11D-1683-08	15505130	53384668	5744315	115	33929											
ZNF446	55663	broad.mit.edu	37	chr19	58991828	58991828	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggccaggtgtgcagtcccCggggctagccaccggggaaa	7	5	17	12	2	0	0	0	0	0	0	1	1	1	1	5	6	2	2	5	6	2	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr19:58991828C>T	uc002qsz.2	+	7	1205	c.1088C>T	c.(1087-1089)CCG>CTG	p.P363L	ZNF446_uc002qta.2_Missense_Mutation_p.R335W|ZNF446_uc010eur.2_3'UTR|SLC27A5_uc002qtb.2_RNA	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	363					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GTGCAGTCCCCGGGGCTAGCC	0.657													7	30					0	0	0	0	T	58991828	T	T	58991828	3	4	180	1	0	0	0	0	1	0	0	0	17986	652	23	1	1110	1	ZNF446	19	58991828	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	5607160	58991828	137155	116	33930											
ZSWIM3	140831	broad.mit.edu	37	chr20	44507028	44507028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccaaacacaggccagcctGagaagcaaggacggaacgac	15	2	11	13	2	0	1	0	1	0	1	1	5	1	3	3	3	4	1	3	3	4	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr20:44507028G>A	uc002xqd.2	+	2	2034	c.1831G>A	c.(1831-1833)GAG>AAG	p.E611K	ZSWIM3_uc010zxg.1_Missense_Mutation_p.E605K|ZSWIM1_uc010zxh.1_5'Flank|ZSWIM1_uc010ghi.2_5'Flank	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	611							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				AGGCCAGCCTGAGAAGCAAGG	0.587													18	80					0	0	0	0	A	44507028	A	A	44507028	3	1	180	1	0	0	0	0	1	0	0	0	18309	1291	45	2	1837	2	ZSWIM3	20	44507028	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08		44507028	18518492	117	33931											
KRTAP10-6	386674	broad.mit.edu	37	chr21	46011580	46011580	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgctggcagggggaggaGgtgcagcaagctggctggca	7	5	21	8	1	0	0	0	0	0	0	0	2	0	2	0	7	4	7	0	7	1	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr21:46011580G>T	uc002zfm.2	-	1	807	c.786C>A	c.(784-786)ACC>ACA	p.T262T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198688	NP_941961	P60371	KR106_HUMAN	keratin associated protein 10-6	262	23.|29 X 5 AA repeats of C-C-X(3).					keratin filament					0						AGGGGGAGGAGGTGCAGCAAG	0.652													28	84					2.68265e-12	2.93641e-12	1	0	T	46011580	T	T	46011580	2	4	180	1	0	0	0	0	0	0	0	1	8552	987	35	4		4	KRTAP10-6	21	46011580	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08		46011580	2118315	118	33932											
TPST2	8459	broad.mit.edu	37	chr22	26932363	26932363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcgatctgggccatgtccCgcaccacatccccagggatg	7	6	13	15	2	1	0	0	0	1	0	3	2	3	1	5	3	0	1	5	3	0	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr22:26932363C>T	uc003acv.2	-	3	1100	c.932G>A	c.(931-933)CGG>CAG	p.R311Q	TPST2_uc003acw.2_Missense_Mutation_p.R311Q|TPST2_uc003acx.2_Missense_Mutation_p.R311Q	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	311	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						GGCCATGTCCCGCACCACATC	0.602													5	26					0	0	0	0	T	26932363	T	T	26932363	3	4	180	1	0	0	0	0	1	0	0	0	16495	652	23	1	213	1	TPST2	22	26932363	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08		26932363	24372203	119	33933											
SMTN	6525	broad.mit.edu	37	chr22	31492832	31492832	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcacagccagcgggcagctGatggctctgctgtcagcact	7	7	14	13	1	2	1	1	1	1	0	2	1	2	1	1	3	5	6	1	3	0	0			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chr22:31492832G>A	uc003ajl.1	+	14	2193	c.1975G>A	c.(1975-1977)GAT>AAT	p.D659N	SMTN_uc003ajk.1_Missense_Mutation_p.D659N|SMTN_uc003ajm.1_Missense_Mutation_p.D659N|SMTN_uc011ale.1_Missense_Mutation_p.D744N|SMTN_uc011alf.1_Missense_Mutation_p.D715N|SMTN_uc003ajn.1_Missense_Mutation_p.D682N|SMTN_uc011alg.1_Missense_Mutation_p.D115N|SMTN_uc003ajo.1_Intron|SMTN_uc011alh.1_RNA|SMTN_uc010gwe.1_Intron	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	659					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						GCGGGCAGCTGATGGCTCTGC	0.687													19	55					0	0	0	0	A	31492832	A	A	31492832	3	1	180	1	0	0	0	0	1	0	0	0	14878	1290	45	2	2025	2	SMTN	22	31492832	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	4560469	31492832	19811734	120	33934											
CDKL5	6792	broad.mit.edu	37	chrX	18668577	18668577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagcctcacactccgtgcGtcccaaaccgagcccttcat	10	7	7	17	3	2	1	2	0	0	1	4	2	4	1	5	0	4	0	5	0	2	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chrX:18668577G>A	uc004cym.2	+	20	3098	c.2845G>A	c.(2845-2847)GTC>ATC	p.V949I	CDKL5_uc004cyn.2_Missense_Mutation_p.V949I|RS1_uc004cyo.2_Intron	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	949					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					CACTCCGTGCGTCCCAAACCG	0.582													23	59					0	0	0	0	A	18668577	A	A	18668577	3	1	180	1	0	0	0	0	1	0	0	0	3172	1145	40	1	2919	1	CDKL5	23	18668577	Missense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08		18668577	136601983	121	33935											
PJA1	64219	broad.mit.edu	37	chrX	68381831	68381831	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcactagcaccggggccAgggctggtgccagtgctggc	5	6	17	13	1	0	0	0	0	0	0	0	0	0	0	3	6	3	4	3	6	1	1			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chrX:68381831A>C	uc004dxh.2	-	2	1537	c.1251T>G	c.(1249-1251)CCT>CCG	p.P417P	PJA1_uc011mpi.1_Silent_p.P135P|PJA1_uc004dxg.2_Silent_p.P229P|PJA1_uc004dxi.2_Silent_p.P362P	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	417							zinc ion binding				0						CACCGGGGCCAGGGCTGGTGC	0.622													8	55					0	0	0	0	C	68381831	C	C	68381831	2	2	180	1	0	0	0	0	0	0	0	1	12016	175	7	5		5	PJA1	23	68381831	Silent	SNP	A	TCGA-CV-5966-01A-11D-1683-08	49713254	68381831	86888729	122	33936											
ARL13A	392509	broad.mit.edu	37	chrX	100240775	100240775	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggccgggaagcatggccaAactactatgcacaggcccat	12	5	12	12	1	0	0	0	0	0	0	0	1	0	1	3	4	4	2	3	4	4	2			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chrX:100240775A>T	uc004ego.2	+	4	366	c.250A>T	c.(250-252)AAC>TAC	p.N84Y	ARL13A_uc011mrf.1_Missense_Mutation_p.N84Y|ARL13A_uc010nng.2_Missense_Mutation_p.N84Y	NM_001012990	NP_001013008	Q5H913	AR13A_HUMAN	ADP-ribosylation factor-like 13 isoform a	84							GTP binding			ovary(1)	1						AGCATGGCCAAACTACTATGC	0.468													15	23					0	0	0	0	T	100240775	T	T	100240775	3	4	180	1	0	0	0	0	1	0	0	0	928	14	1	5	260	5	ARL13A	23	100240775	Missense_Mutation	SNP	A	TCGA-CV-5966-01A-11D-1683-08	31858944	100240775	55029785	123	33937											
IRS4	8471	broad.mit.edu	37	chrX	107979062	107979062	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgaagtattcgtcttgggtGaaaagagcaatgaggtgtcg	11	10	15	5	3	1	3	0	2	1	1	3	4	1	3	0	2	1	2	0	2	5	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chrX:107979062G>A	uc004eoc.2	-	1	546	c.513C>T	c.(511-513)TTC>TTT	p.F171F		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	171	PH.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CGTCTTGGGTGAAAAGAGCAA	0.597													7	55					0	0	0	0	A	107979062	A	A	107979062	2	1	180	1	0	0	0	0	0	0	0	1	7881	1281	45	2		2	IRS4	23	107979062	Silent	SNP	G	TCGA-CV-5966-01A-11D-1683-08	7738287	107979062	47291498	124	33938											
DOCK11	139818	broad.mit.edu	37	chrX	117775197	117775197	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttccaccaggcacttcttGaaggcaatacagctactgaa	12	11	7	11	0	1	2	0	2	1	0	2	2	2	2	2	2	3	3	2	2	5	6			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chrX:117775197G>T	uc004eqp.2	+	39	4252	c.4189G>T	c.(4189-4191)GAA>TAA	p.E1397*	DOCK11_uc004eqq.2_Nonsense_Mutation_p.E1176*	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1397					blood coagulation	cytosol	GTP binding			ovary(3)	3						GGCACTTCTTGAAGGCAATAC	0.368													20	62					1.1804e-14	1.30085e-14	1	0	T	117775197	T	T	117775197	4	4	180	1	0	0	0	0	0	1	0	0	4708	1291	45	2	4343	2	DOCK11	23	117775197	Nonsense_Mutation	SNP	G	TCGA-CV-5966-01A-11D-1683-08	9796135	117775197	37495363	125	33939											
ZCCHC12	170261	broad.mit.edu	37	chrX	117959641	117959641	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acaagctcaaggggagaaagCctccctttatgtgatccgtt	11	10	10	10	1	1	2	1	1	0	1	3	3	3	2	3	2	2	2	3	2	4	3			TCGA-CV-5966-01A-11D-1683-08	TCGA-CV-5966-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	24ad5336-f5ee-49c0-a176-48411285fbe8	3c2e0c46-e5df-40b0-bf0c-8b41f7f8beb6	g.chrX:117959641C>T	uc004equ.2	+	4	907	c.434C>T	c.(433-435)GCC>GTC	p.A145V		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						ggggagaaagcctccctttat	0.01													35	110					0	0	0	0	T	117959641	T	T	117959641	3	4	180	1	0	0	0	0	1	0	0	0	17648	739	26	4	436	4	ZCCHC12	23	117959641	Missense_Mutation	SNP	C	TCGA-CV-5966-01A-11D-1683-08	184444	117959641	37310919	126	33940											
SLC45A1	50651	broad.mit.edu	37	chr1	8390837	8390837	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagagggtgccctgacctcCggctgtgacggggacattct	7	8	15	11	2	1	3	0	2	1	1	2	5	2	4	3	4	1	1	3	4	0	1	rs149921947	byFrequency	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:8390837C>T	uc001apb.2	+	4	1284	c.1284C>T	c.(1282-1284)TCC>TCT	p.S428S	SLC45A1_uc001apc.2_Silent_p.S126S	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	428					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCCTGACCTCCGGCTGTGACG	0.657													12	82					0	0	0	0	T	8390837	T	T	8390837	2	4	181	1	0	0	0	0	0	0	0	1	14704	639	23	1		1	SLC45A1	1	8390837	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08		8390837	240859784	1	33941											
TARDBP	23435	broad.mit.edu	37	chr1	11080498	11080498	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgatcagcaaagccaagatGagcctttgagaagcagaaaa	17	7	10	7	0	1	5	1	3	0	3	1	6	1	5	2	0	4	2	2	0	5	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:11080498G>C	uc001art.2	+	5	690	c.556G>C	c.(556-558)GAG>CAG	p.E186Q	TARDBP_uc010oap.1_Missense_Mutation_p.E70Q	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	186	RRM 1.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		AAGCCAAGATGAGCCTTTGAG	0.398													11	74					0	0	0	0	C	11080498	C	C	11080498	3	2	181	1	0	0	0	0	1	0	0	0	15623	1291	45	2	570	2	TARDBP	1	11080498	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	2689661	11080498	238170123	2	33942											
PINK1	65018	broad.mit.edu	37	chr1	20975048	20975048	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggctgctgcctggctgatGagagcatcggcctgcagttg	5	11	15	10	1	0	2	0	2	0	1	1	3	0	2	2	3	4	6	2	3	0	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:20975048G>A	uc001bdm.2	+	6	1268	c.1174G>A	c.(1174-1176)GAG>AAG	p.E392K	PINK1_uc001bdn.2_Missense_Mutation_p.E85K	NM_032409	NP_115785	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1 precursor	392	Protein kinase.|Cytoplasmic (Potential).				cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			ovary(2)|central_nervous_system(1)	3		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCTGGCTGATGAGAGCATCGG	0.612													3	29					0	0	0	0	A	20975048	A	A	20975048	3	1	181	1	0	0	0	0	1	0	0	0	11987	1291	45	2	1196	2	PINK1	1	20975048	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	9894550	20975048	228275573	3	33943											
HP1BP3	50809	broad.mit.edu	37	chr1	21103166	21103166	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccctttggctgctctgcctCactcgaagtagcaggtggag	6	10	12	13	1	2	0	1	0	1	0	3	2	2	1	3	3	3	4	3	3	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:21103166C>T	uc001bdw.1	-	4	414	c.274G>A	c.(274-276)GAG>AAG	p.E92K	HP1BP3_uc001bdv.1_Missense_Mutation_p.E54K|HP1BP3_uc010odh.1_Missense_Mutation_p.E54K|HP1BP3_uc001bdy.1_Missense_Mutation_p.E92K|HP1BP3_uc001bdz.2_RNA|HP1BP3_uc001bea.2_Missense_Mutation_p.E91K|HP1BP3_uc001beb.2_Missense_Mutation_p.E92K	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	92					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		TGCTCTGCCTCACTCGAAGTA	0.423													21	102					0	0	0	0	T	21103166	T	T	21103166	3	4	181	1	0	0	0	0	1	0	0	0	7367	835	29	2	1427	2	HP1BP3	1	21103166	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	128118	21103166	228147455	4	33944											
SRRM1	10250	broad.mit.edu	37	chr1	24978971	24978971	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacctataccagagcctaaaGaaccttctccggaaaaaaat	18	7	5	11	1	1	2	0	0	1	2	2	3	1	3	5	1	4	0	5	1	9	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:24978971G>C	uc001bjm.2	+	7	996	c.772G>C	c.(772-774)GAA>CAA	p.E258Q	SRRM1_uc010oel.1_Missense_Mutation_p.E258Q|SRRM1_uc009vrh.1_Missense_Mutation_p.E219Q|SRRM1_uc009vri.1_Missense_Mutation_p.E175Q|SRRM1_uc010oem.1_RNA	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	258	Pro-rich.|Arg-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		AGAGCCTAAAGAACCTTCTCC	0.443													3	25					0	0	0	0	C	24978971	C	C	24978971	3	2	181	1	0	0	0	0	1	0	0	0	15234	943	33	2	798	2	SRRM1	1	24978971	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	3875805	24978971	224271650	5	33945											
TIE1	7075	broad.mit.edu	37	chr1	43778831	43778831	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagccccccgacacctccaCgcccaggccctctcagactc	7	4	6	24	2	1	1	1	0	1	1	4	2	2	1	8	1	1	0	8	1	0	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:43778831C>T	uc001ciu.2	+	13	2032	c.1953C>T	c.(1951-1953)CAC>CAT	p.H651H	TIE1_uc010okd.1_Silent_p.H651H|TIE1_uc010oke.1_Silent_p.H606H|TIE1_uc009vwq.2_Silent_p.H607H|TIE1_uc010okf.1_Silent_p.H296H|TIE1_uc010okg.1_Silent_p.H296H	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	651	Fibronectin type-III 3.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GACACCTCCACGCCCAGGCCC	0.637													6	45					0	0	0	0	T	43778831	T	T	43778831	2	4	181	1	0	0	0	0	0	0	0	1	15959	535	19	1		1	TIE1	1	43778831	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	18799860	43778831	205471790	6	33946											
ST3GAL3	6487	broad.mit.edu	37	chr1	44303969	44303969	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgcttcagccttgatgacGgccatcttcccccggtaagt	7	12	9	13	2	2	2	1	2	1	0	3	2	3	2	4	2	2	2	4	2	2	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:44303969G>A	uc001ckc.2	+	5	465	c.288G>A	c.(286-288)ACG>ACA	p.T96T	ST3GAL3_uc009vwu.1_RNA|ST3GAL3_uc010okj.1_RNA|ST3GAL3_uc001cjz.2_Silent_p.T111T|ST3GAL3_uc001cka.2_Silent_p.T80T|ST3GAL3_uc001ckb.2_Silent_p.T165T|ST3GAL3_uc001ckd.2_Silent_p.T150T|ST3GAL3_uc001cke.2_Silent_p.T80T|ST3GAL3_uc001ckf.2_Silent_p.T134T|ST3GAL3_uc001ckg.2_Silent_p.T96T|ST3GAL3_uc001ckh.2_Silent_p.T111T|ST3GAL3_uc001cki.2_Silent_p.T96T|ST3GAL3_uc009vwv.2_Silent_p.T96T|ST3GAL3_uc001ckj.2_RNA|ST3GAL3_uc009vww.2_RNA|ST3GAL3_uc001ckk.2_Intron|ST3GAL3_uc009vwy.2_Silent_p.T2T|ST3GAL3_uc009vwx.2_RNA|ST3GAL3_uc001ckm.2_Silent_p.T95T|ST3GAL3_uc001ckl.2_Silent_p.T96T|ST3GAL3_uc009vwz.2_5'UTR|ST3GAL3_uc001ckn.2_RNA|ST3GAL3_uc001ckp.2_Silent_p.T95T|ST3GAL3_uc001cko.2_Silent_p.T80T|ST3GAL3_uc009vxa.2_Intron|ST3GAL3_uc001ckq.2_Silent_p.T80T|ST3GAL3_uc001ckr.2_Intron|ST3GAL3_uc009vxb.2_Silent_p.T80T	NM_006279	NP_006270	Q11203	SIAT6_HUMAN	sialyltransferase 6 isoform j	96	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			ovary(3)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				CCTTGATGACGGCCATCTTCC	0.542													28	170					0	0	0	0	A	44303969	A	A	44303969	2	1	181	1	0	0	0	0	0	0	0	1	15282	1103	39	1		1	ST3GAL3	1	44303969	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	525138	44303969	204946652	7	33947											
CDCP2	200008	broad.mit.edu	37	chr1	54610233	54610233	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaggaggtgaagggcggCgggggcaccttgccgcagaa	9	3	20	9	3	0	2	0	1	0	1	0	4	0	4	2	7	1	2	2	7	2	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:54610233C>G	uc001cwv.1	-	2	1181	c.333G>C	c.(331-333)CCG>CCC	p.P111P		NM_201546	NP_963840	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2 precursor	111	CUB 1.					extracellular region				ovary(1)	1						TGAAGGGCGGCGGGGGCACCT	0.587													9	33					0	0	0	0	G	54610233	G	G	54610233	2	3	181	1	0	0	0	0	0	0	0	1	3109	755	27	3		3	CDCP2	1	54610233	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	10306264	54610233	194640388	8	33948											
LRRC40	55631	broad.mit.edu	37	chr1	70618219	70618219	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaaccatttccttcagttCtaccatcctgaaacaaaaat	16	11	3	11	0	2	2	1	1	1	1	4	2	4	2	4	0	3	1	4	0	5	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:70618219C>G	uc001der.1	-	12	1388	c.1336G>C	c.(1336-1338)GAA>CAA	p.E446Q		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	446	LRR 14.									ovary(1)	1						TCCTTCAGTTCTACCATCCTG	0.323													7	35					0	0	0	0	G	70618219	G	G	70618219	3	3	181	1	0	0	0	0	1	0	0	0	9048	922	32	2	488	2	LRRC40	1	70618219	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	16007986	70618219	178632402	9	33949											
AK5	26289	broad.mit.edu	37	chr1	77806120	77806120	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taatcagagactcaaagaaaGattactgaagcgtgcagaac	18	7	9	7	1	2	5	2	1	0	4	2	6	2	5	0	0	4	1	0	0	6	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:77806120G>C	uc001dhn.2	+	6	1015	c.758G>C	c.(757-759)AGA>ACA	p.R253T	AK5_uc001dho.2_Missense_Mutation_p.R227T	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	253					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						CTCAAAGAAAGATTACTGAAG	0.458													11	80					0	0	0	0	C	77806120	C	C	77806120	3	2	181	1	0	0	0	0	1	0	0	0	443	942	33	2	780	2	AK5	1	77806120	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	7187901	77806120	171444501	10	33950											
HSD3B2	3284	broad.mit.edu	37	chr1	119964589	119964589	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acatggcccactccatacccGtacagcaaaaagcttgctga	13	7	7	14	1	0	1	0	1	0	0	1	1	1	1	3	1	5	4	3	1	4	3	rs114527791	by1000genomes	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:119964589G>A	uc001ehs.2	+	3	1238	c.465G>A	c.(463-465)CCG>CCA	p.P155P	HSD3B2_uc001eht.2_Silent_p.P155P|HSD3B2_uc001ehu.2_Intron	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	155			P -> L (in AH2; nonsalt-wasting form).		androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CTCCATACCCGTACAGCAAAA	0.498													21	74					0	0	0	0	A	119964589	A	A	119964589	2	1	181	1	0	0	0	0	0	0	0	1	7430	1132	40	1		1	HSD3B2	1	119964589	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	42158469	119964589	129286032	11	33951											
ANKRD34A	284615	broad.mit.edu	37	chr1	145473612	145473612	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggggcgccgcggtggcctCgctgctccttgcccacggcg	1	7	17	16	6	0	0	0	0	0	0	2	0	1	0	4	5	2	2	4	5	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:145473612C>T	uc001enq.1	+	4	1577	c.284C>T	c.(283-285)TCG>TTG	p.S95L	NBPF10_uc001emp.3_Intron	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	95	ANK 3.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCGGTGGCCTCGCTGCTCCTT	0.721													9	47					0	0	0	0	T	145473612	T	T	145473612	3	4	181	1	0	0	0	0	1	0	0	0	662	893	31	1	286	1	ANKRD34A	1	145473612	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	25509023	145473612	103777009	12	33952											
ANKRD34A	284615	broad.mit.edu	37	chr1	145473671	145473671	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcacgcgggcgcctcggctCttgtccacgccctggaccgc	4	7	12	18	6	2	0	1	0	1	0	4	1	3	1	4	3	0	1	4	3	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:145473671C>G	uc001enq.1	+	4	1636	c.343C>G	c.(343-345)CTT>GTT	p.L115V	NBPF10_uc001emp.3_Intron	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	115	ANK 4.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGCCTCGGCTCTTGTCCACGC	0.701													8	38					0	0	0	0	G	145473671	G	G	145473671	3	3	181	1	0	0	0	0	1	0	0	0	662	913	32	2	345	2	ANKRD34A	1	145473671	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	59	145473671	103776950	13	33953											
MUC1	4582	broad.mit.edu	37	chr1	155160217	155160217	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgctgacgtctgagatcgtCaggttatatcgagaggctgc	8	10	13	10	4	2	3	1	2	1	2	4	5	2	3	1	2	1	3	1	2	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:155160217C>T	uc010pfj.1	-	4	1093	c.687G>A	c.(685-687)CTG>CTA	p.L229L	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_Silent_p.L59L|MUC1_uc001fhz.2_Silent_p.L59L|MUC1_uc010pfb.1_Silent_p.L59L|MUC1_uc010pfc.1_RNA|MUC1_uc009wph.2_Silent_p.L59L|MUC1_uc010pfd.1_Intron|MUC1_uc010pfe.1_RNA|MUC1_uc010pff.1_Intron|MUC1_uc009wpi.2_Silent_p.L59L|MUC1_uc010pfg.1_Intron|MUC1_uc010pfh.1_Silent_p.L205L|MUC1_uc010pfi.1_Silent_p.L205L|MUC1_uc010pfk.1_RNA|MUC1_uc010pfl.1_RNA|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Silent_p.L81L|MUC1_uc001fip.2_Intron|MUC1_uc009wqg.2_Silent_p.L90L|MUC1_uc009wpo.2_Silent_p.L96L|MUC1_uc009wps.2_Silent_p.L117L|MUC1_uc009wpt.2_Silent_p.L120L|MUC1_uc001fic.2_Silent_p.L108L|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Silent_p.L122L|MUC1_uc009wpv.2_Intron|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Intron|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Silent_p.L118L|MUC1_uc001fid.2_Silent_p.L109L|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Silent_p.L143L|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Silent_p.L59L|MUC1_uc001fiq.2_Silent_p.L59L|MUC1_uc009wpz.2_Silent_p.L161L|MUC1_uc010pfn.1_Silent_p.L134L|MUC1_uc009wqa.2_Silent_p.L217L|MUC1_uc010pfo.1_Intron|MUC1_uc010pfp.1_Intron|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Silent_p.L134L|MUC1_uc009wqc.2_Silent_p.L131L|MUC1_uc009wqd.2_Silent_p.L155L|MUC1_uc009wqb.2_Silent_p.L59L|MUC1_uc010pfq.1_Silent_p.L131L|MUC1_uc010pfr.1_Intron|MUC1_uc001fit.2_Silent_p.L59L|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Intron|MUC1_uc009wpm.2_Silent_p.L152L|MUC1_uc009wpp.2_Intron|MUC1_uc010pfs.1_RNA|MUC1_uc001fik.2_Silent_p.L152L|MUC1_uc001fio.2_Intron|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Silent_p.L143L|MUC1_uc001fis.1_Intron			P15941	MUC1_HUMAN	SubName: Full=Mucin 1, cell surface associated;	1134	Extracellular (Potential).|SEA.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTGAGATCGTCAGGTTATATC	0.552			T	IGH@	B-NHL								7	23					0	0	0	0	T	155160217	T	T	155160217	2	4	181	1	0	0	0	0	0	0	0	1	10023	813	29	2		2	MUC1	1	155160217	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	9686546	155160217	94090404	14	33954											
CRB1	23418	broad.mit.edu	37	chr1	197396601	197396601	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagagtatgtggcaggcagaTttggccaggatgactccact	11	9	13	8	0	0	3	0	1	0	2	1	4	1	4	2	4	0	3	2	4	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:197396601T>C	uc001gtz.2	+	7	2281	c.2146T>C	c.(2146-2148)TTT>CTT	p.F716L	CRB1_uc010poz.1_Missense_Mutation_p.F647L|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.F604L|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.F197L|CRB1_uc001gub.1_Missense_Mutation_p.F365L	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	716	Extracellular (Potential).|Laminin G-like 2.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GGCAGGCAGATTTGGCCAGGA	0.433													5	31					0	0	0	0	C	197396601	C	C	197396601	3	2	181	1	0	0	0	0	1	0	0	0	3863	1493	52	5	2172	5	CRB1	1	197396601	Missense_Mutation	SNP	T	TCGA-CV-5970-01A-11D-1683-08	42236384	197396601	51854020	15	33955											
PIK3C2B	5287	broad.mit.edu	37	chr1	204408140	204408140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtccttgaacgagccggtcaCcccatgctccacctggatct	7	9	9	16	2	2	1	1	1	1	0	4	3	4	2	6	2	3	1	6	2	1	1	rs75201325		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:204408140C>T	uc001haw.2	-	24	3918	c.3439G>A	c.(3439-3441)GTG>ATG	p.V1147M	PIK3C2B_uc010pqv.1_Missense_Mutation_p.V1119M	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1147	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GAGCCGGTCACCCCATGCTCC	0.592													9	19					0	0	0	0	T	204408140	T	T	204408140	3	4	181	1	0	0	0	0	1	0	0	0	11965	507	18	4	1509	4	PIK3C2B	1	204408140	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	7011539	204408140	44842481	16	33956											
TARBP1	6894	broad.mit.edu	37	chr1	234565343	234565358	+	Frame_Shift_Del	DEL	GAGAGGCACACCCATT	-	-																															gatattttttcaacaggaaaGagaggcacacccattgatca																										TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:234565343_234565358delGAGAGGCACACCCATT	uc001hwd.2	-	16	2675_2690	c.2675_2690delAATGGGTGTGCCTCTC	c.(2674-2691)CAATGGGTGTGCCTCTCTfs	p.Q892fs		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	892_897					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity	p.W893*(1)		ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			CAACAGGAAAGAGAGGCACACCCATTGATCATGAAT	0.398													---	---	---								-	234565358	-	-	234565343	7	5	181	1	0	1	0	1	0	0	0	0	15621	942	33	0	2235	0	TARBP1	1	234565343	Frame_Shift_Del	DEL	GAGAGGCACACCCATT	TCGA-CV-5970-01A-11D-1683-08	30157203	234565343	14685278	17	33957											
NID1	4811	broad.mit.edu	37	chr1	236189239	236189239	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagagcatagcgcaagatCttctcctcctggttgtacag	9	11	10	11	1	2	2	0	1	2	2	4	3	3	2	2	1	3	4	2	1	3	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr1:236189239C>A	uc001hxo.2	-	8	2043	c.1941G>T	c.(1939-1941)AAG>AAT	p.K647N	NID1_uc009xgd.2_Missense_Mutation_p.K647N	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	647	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	AGCGCAAGATCTTCTCCTCCT	0.577													39	174					5.59293e-11	6.0607e-11	1	0	A	236189239	A	A	236189239	3	1	181	1	0	0	0	0	1	0	0	0	10468	912	32	2	1854	2	NID1	1	236189239	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	1623896	236189239	13061382	18	33958											
ASXL2	55252	broad.mit.edu	37	chr2	25978930	25978930	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttgggctgctgaagtgaaGaattcattgttaagggctga	10	12	13	6	0	1	4	1	3	0	1	1	4	1	4	1	2	1	4	1	2	4	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:25978930G>A	uc002rgs.2	-	9	1214	c.993C>T	c.(991-993)TTC>TTT	p.F331F	ASXL2_uc002rgt.1_Silent_p.F71F	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	331					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGAAGTGAAGAATTCATTGT	0.453													12	76					0	0	0	0	A	25978930	A	A	25978930	2	1	181	1	0	0	0	0	0	0	0	1	1069	933	33	2		2	ASXL2	2	25978930	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08		25978930	217220443	19	33959											
CENPA	1058	broad.mit.edu	37	chr2	27015013	27015013	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcaggcgcttcctcccatCaacacagtcggcggagacaa	10	6	10	15	3	2	1	2	0	0	1	5	2	4	1	2	3	1	2	2	3	2	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:27015013C>T	uc002rhr.2	+	2	298	c.115C>T	c.(115-117)CAA>TAA	p.Q39*	CENPA_uc002rht.2_RNA|CENPA_uc002rhs.2_Nonsense_Mutation_p.Q39*	NM_001809	NP_001800	P49450	CENPA_HUMAN	centromere protein A isoform a	39					CenH3-containing nucleosome assembly at centromere|establishment of mitotic spindle orientation|interspecies interaction between organisms|kinetochore assembly|mitotic prometaphase|protein localization to chromosome, centromeric region	condensed nuclear chromosome kinetochore|cytosol|nucleoplasm|nucleosome	chromatin binding|DNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCCTCCCATCAACACAGTCG	0.512													7	16					0	0	0	0	T	27015013	T	T	27015013	4	4	181	1	0	0	0	0	0	1	0	0	3241	827	29	2	121	2	CENPA	2	27015013	Nonsense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	1036083	27015013	216184360	20	33960											
CAD	790	broad.mit.edu	37	chr2	27463149	27463149	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagacacctgaaagaccccGccgtggcatcccagggcttc	9	5	10	17	2	0	3	0	1	0	2	2	3	1	3	6	2	0	2	6	2	1	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:27463149G>A	uc002rji.2	+	35	5675	c.5513G>A	c.(5512-5514)CGC>CAC	p.R1838H	CAD_uc010eyw.2_Missense_Mutation_p.R1775H	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1838	Linker.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GAAAGACCCCGCCGTGGCATC	0.443													15	112					0	0	0	0	A	27463149	A	A	27463149	3	1	181	1	0	0	0	0	1	0	0	0	2577	1087	38	1	5651	1	CAD	2	27463149	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	448136	27463149	215736224	21	33961											
SLC30A3	7781	broad.mit.edu	37	chr2	27480162	27480162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcctccagcggtgcatactCtgctcccctagacccgtggc	5	9	9	18	2	1	1	0	0	1	1	4	1	4	1	5	2	4	2	5	2	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:27480162C>T	uc002rjk.2	-	5	823	c.637G>A	c.(637-639)GAG>AAG	p.E213K	SLC30A3_uc002rjj.2_Silent_p.Q58Q|SLC30A3_uc010ylh.1_Missense_Mutation_p.E208K	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	213	Cytoplasmic (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGCATACTCTGCTCCCCTA	0.672													8	17					0	0	0	0	T	27480162	T	T	27480162	3	4	181	1	0	0	0	0	1	0	0	0	14620	922	32	2	545	2	SLC30A3	2	27480162	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	17013	27480162	215719211	22	33962											
STRN	6801	broad.mit.edu	37	chr2	37078179	37078179	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatttgatgtgcctgtcttCatgagcagtgatgctgatcg	8	14	12	7	1	2	4	1	4	1	0	3	5	2	4	1	0	3	2	1	0	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:37078179C>T	uc002rpn.2	-	16	2059	c.2050G>A	c.(2050-2052)GAA>AAA	p.E684K	STRN_uc010ezx.2_Missense_Mutation_p.E647K	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	684	WD 4.				dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TGCCTGTCTTCATGAGCAGTG	0.328													14	64					0	0	0	0	T	37078179	T	T	37078179	3	4	181	1	0	0	0	0	1	0	0	0	15395	835	29	2	304	2	STRN	2	37078179	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	9598017	37078179	206121194	23	33963											
SLC8A1	6546	broad.mit.edu	37	chr2	40656665	40656665	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaacagaagtctcctatcCgctacccaagcgaacacaac	16	6	5	14	2	1	1	0	0	1	1	3	2	2	1	3	0	5	1	3	0	8	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:40656665C>G	uc002rrx.2	-	1	780	c.756G>C	c.(754-756)GCG>GCC	p.A252A	SLC8A1_uc002rry.2_Silent_p.A252A|SLC8A1_uc002rrz.2_Silent_p.A252A|SLC8A1_uc002rsa.2_Silent_p.A252A|SLC8A1_uc002rsd.3_Silent_p.A252A|SLC8A1_uc002rsb.1_Silent_p.A252A|SLC8A1_uc010fan.1_Silent_p.A252A|SLC8A1_uc002rsc.1_Silent_p.A252A	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	252	Helical; (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GTCTCCTATCCGCTACCCAAG	0.443													18	107					0	0	0	0	G	40656665	G	G	40656665	2	3	181	1	0	0	0	0	0	0	0	1	14770	639	23	3		3	SLC8A1	2	40656665	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	3578486	40656665	202542708	24	33964											
ATP6V1E2	90423	broad.mit.edu	37	chr2	46739793	46739793	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctcattggcttcctgctCaatgaaagccatcatgtgct	8	15	7	11	0	3	1	3	1	1	0	5	1	4	1	2	1	3	3	2	1	2	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:46739793C>G	uc002ruy.2	-	2	1172	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	ATP6V1E2_uc002ruz.2_Missense_Mutation_p.E20Q	NM_080653	NP_542384	Q96A05	VATE2_HUMAN	ATPase, H+ transporting, lysosomal 31kDa, V1	20					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain	proton-transporting ATPase activity, rotational mechanism			ovary(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.151)			GCTTCCTGCTCAATGAAAGCC	0.507													10	53					0	0	0	0	G	46739793	G	G	46739793	3	3	181	1	0	0	0	0	1	0	0	0	1186	835	29	2	626	2	ATP6V1E2	2	46739793	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	6083128	46739793	196459580	25	33965											
MSH2	4436	broad.mit.edu	37	chr2	47656948	47656948	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttacaagaagatttacttCgtcgattcccagatcttaac	12	14	5	10	2	1	3	0	0	1	3	4	4	2	3	1	0	3	0	1	0	5	7	rs63750496		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:47656948C>T	uc002rvy.1	+	7	1212	c.1144C>T	c.(1144-1146)CGT>TGT	p.R382C	MSH2_uc010yoh.1_Missense_Mutation_p.R316C|MSH2_uc002rvz.2_Missense_Mutation_p.R382C|MSH2_uc010fbg.2_Missense_Mutation_p.R192C	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	382					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.?(1)		large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGATTTACTTCGTCGATTCCC	0.328			D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				10	44					0	0	0	0	T	47656948	T	T	47656948	3	4	181	1	0	0	0	0	1	0	0	0	9923	884	31	1	1170	1	MSH2	2	47656948	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	917155	47656948	195542425	26	33966											
LRRTM1	347730	broad.mit.edu	37	chr2	80530153	80530153	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtactcgatctcgttgccCgacaagtccattttctccag	8	13	7	13	3	2	0	0	0	2	0	6	2	3	0	3	0	2	2	3	0	2	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:80530153C>G	uc002sok.1	-	2	1062	c.792G>C	c.(790-792)TCG>TCC	p.S264S	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	264	LRR 8.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						TCTCGTTGCCCGACAAGTCCA	0.607										HNSCC(69;0.2)			8	44					0	0	0	0	G	80530153	G	G	80530153	2	3	181	1	0	0	0	0	0	0	0	1	9089	639	23	3		3	LRRTM1	2	80530153	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	32873205	80530153	162669220	27	33967											
LRRTM1	347730	broad.mit.edu	37	chr2	80530267	80530267	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaggcgcgggaagtgggcGaagttcaccttgaccaagtc	10	7	15	9	3	1	2	1	2	0	0	2	4	1	3	2	3	0	1	2	3	3	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:80530267G>A	uc002sok.1	-	2	948	c.678C>T	c.(676-678)TTC>TTT	p.F226F	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	226	LRR 6.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GGAAGTGGGCGAAGTTCACCT	0.582										HNSCC(69;0.2)			17	87					0	0	0	0	A	80530267	A	A	80530267	2	1	181	1	0	0	0	0	0	0	0	1	9089	1049	37	1		1	LRRTM1	2	80530267	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	114	80530267	162669106	28	33968											
KYNU	8942	broad.mit.edu	37	chr2	143798151	143798151	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccgtctcatgtagaggagcGggggtgccagctaacaataa	11	8	13	9	2	1	1	1	0	1	1	3	2	2	2	2	3	4	2	2	3	4	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:143798151G>A	uc002tvl.2	+	13	1326	c.1196G>A	c.(1195-1197)CGG>CAG	p.R399Q	KYNU_uc010fnm.2_Missense_Mutation_p.R399Q	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	399					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	GTAGAGGAGCGGGGGTGCCAG	0.408													9	48					0	0	0	0	A	143798151	A	A	143798151	3	1	181	1	0	0	0	0	1	0	0	0	8627	1116	39	1	1268	1	KYNU	2	143798151	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	63267884	143798151	99401222	29	33969											
RIF1	55183	broad.mit.edu	37	chr2	152293769	152293769	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttcagagccattggaacatCcgttaatcagcagcccttcc	10	11	7	13	1	2	1	2	0	0	1	4	2	4	2	4	1	4	2	4	1	2	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:152293769C>T	uc002txm.2	+	13	1517	c.1387C>T	c.(1387-1389)CCG>TCG	p.P463S	RIF1_uc002txl.2_Missense_Mutation_p.P463S|RIF1_uc010fnv.1_Missense_Mutation_p.P427S|RIF1_uc002txn.2_Missense_Mutation_p.P463S|RIF1_uc002txo.2_Missense_Mutation_p.P463S|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	463					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		ATTGGAACATCCGTTAATCAG	0.338													11	52					0	0	0	0	T	152293769	T	T	152293769	3	4	181	1	0	0	0	0	1	0	0	0	13424	855	30	2	1433	2	RIF1	2	152293769	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	8495618	152293769	90905604	30	33970											
PLA2R1	22925	broad.mit.edu	37	chr2	160801458	160801458	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccttttttttcttgacacGgggatagctgccataatcct	8	15	8	10	1	1	1	0	1	1	0	2	2	2	2	3	2	3	1	3	2	2	7			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:160801458G>A	uc002ube.1	-	28	4310	c.4103C>T	c.(4102-4104)CCG>CTG	p.P1368L	PLA2R1_uc010zcp.1_Missense_Mutation_p.P1366L	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1368	Extracellular (Potential).|C-type lectin 8.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TTCTTGACACGGGGATAGCTG	0.428													12	92					0	0	0	0	A	160801458	A	A	160801458	3	1	181	1	0	0	0	0	1	0	0	0	12065	1116	39	1	300	1	PLA2R1	2	160801458	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	8507689	160801458	82397915	31	33971											
SCN1A	6323	broad.mit.edu	37	chr2	166856246	166856246	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacttacatttctggaatcaActgctgcatacattatatcc	12	15	4	10	0	2	0	1	0	1	0	3	1	3	1	1	1	6	2	1	1	7	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:166856246A>G	uc010zcz.1	-	22	4310	c.4292T>C	c.(4291-4293)GTT>GCT	p.V1431A	SCN1A_uc002udo.3_Missense_Mutation_p.V1311A|SCN1A_uc010fpk.2_Missense_Mutation_p.V1283A	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1442	III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCTGGAATCAACTGCTGCATA	0.308													12	84					0	0	0	0	G	166856246	G	G	166856246	3	3	181	1	0	0	0	0	1	0	0	0	13979	43	2	5	1724	5	SCN1A	2	166856246	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08	6054788	166856246	76343127	32	33972											
LRP2	4036	broad.mit.edu	37	chr2	170101321	170101321	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaggcaggaagcaggtgcGtgggtggggcagttgtgctc	7	8	19	7	1	1	0	1	0	0	0	2	1	1	1	0	6	3	5	0	6	2	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:170101321G>A	uc002ues.2	-	22	3525	c.3312C>T	c.(3310-3312)CAC>CAT	p.H1104H	LRP2_uc010zdf.1_Silent_p.H967H	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1104	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AAGCAGGTGCGTGGGTGGGGC	0.537													16	97					0	0	0	0	A	170101321	A	A	170101321	2	1	181	1	0	0	0	0	0	0	0	1	9006	1136	40	1		1	LRP2	2	170101321	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	3245075	170101321	73098052	33	33973											
GORASP2	26003	broad.mit.edu	37	chr2	171806117	171806117	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcctgtaaagatgcttatCtatagcagcaaaacattgga	16	10	8	7	0	1	1	0	0	1	1	1	2	1	2	1	1	5	4	1	1	8	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:171806117C>G	uc002ugk.2	+	3	353	c.213C>G	c.(211-213)ATC>ATG	p.I71M	GORASP2_uc002ugj.2_Missense_Mutation_p.I3M|GORASP2_uc010zdl.1_Missense_Mutation_p.I83M|GORASP2_uc010zdm.1_Missense_Mutation_p.I27M|GORASP2_uc002ugl.2_Missense_Mutation_p.I3M	NM_015530	NP_056345	Q9H8Y8	GORS2_HUMAN	golgi reassembly stacking protein 2	71	PDZ.					Golgi membrane				breast(1)|central_nervous_system(1)	2						AGATGCTTATCTATAGCAGCA	0.438													9	59					0	0	0	0	G	171806117	G	G	171806117	3	3	181	1	0	0	0	0	1	0	0	0	6613	903	32	2	223	2	GORASP2	2	171806117	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	1704796	171806117	71393256	34	33974											
HAT1	8520	broad.mit.edu	37	chr2	172809472	172809472	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagcctgtcaacaatgttcCgtgttgaatatgcatctaaa	12	13	8	8	1	2	1	1	1	1	0	3	1	3	1	2	0	3	4	2	0	7	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:172809472C>T	uc002uhi.2	+	4	338	c.262C>T	c.(262-264)CGT>TGT	p.R88C	HAT1_uc010fqi.2_Intron|HAT1_uc002uhj.2_Missense_Mutation_p.R3C	NM_003642	NP_003633	O14929	HAT1_HUMAN	histone acetyltransferase 1	88					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)			AACAATGTTCCGTGTTGAATA	0.313													10	45					0	0	0	0	T	172809472	T	T	172809472	3	4	181	1	0	0	0	0	1	0	0	0	7003	652	23	1	276	1	HAT1	2	172809472	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	1003355	172809472	70389901	35	33975											
TTN	7273	broad.mit.edu	37	chr2	179403830	179403830	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgagtcttgttgtgtctgacCcacttgtcagtggatgtctc	5	16	11	9	0	4	2	1	2	3	0	5	3	4	3	1	1	0	1	1	1	0	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:179403830C>G	uc010zfg.1	-	302	91352	c.91128G>C	c.(91126-91128)TGG>TGC	p.W30376C	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.W24071C|TTN_uc010zfi.1_Missense_Mutation_p.W24004C|TTN_uc010zfj.1_Missense_Mutation_p.W23879C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31303							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTGTCTGACCCACTTGTCAG	0.498													9	57					0	0	0	0	G	179403830	G	G	179403830	3	3	181	1	0	0	0	0	1	0	0	0	16803	624	22	4	9187	4	TTN	2	179403830	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	6594358	179403830	63795543	36	33976											
TTN	7273	broad.mit.edu	37	chr2	179424911	179424911	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatggaggagatggtaggaAcactggatcttctgccctaa	11	9	14	7	0	2	1	0	0	2	1	2	6	2	5	1	6	2	1	1	6	3	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:179424911A>G	uc010zfg.1	-	275	78468	c.78244T>C	c.(78244-78246)TTC>CTC	p.F26082L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.F19777L|TTN_uc010zfi.1_Missense_Mutation_p.F19710L|TTN_uc010zfj.1_Missense_Mutation_p.F19585L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27009							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATGGTAGGAACACTGGATCT	0.463													17	65					0	0	0	0	G	179424911	G	G	179424911	3	3	181	1	0	0	0	0	1	0	0	0	16803	43	2	5	22179	5	TTN	2	179424911	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08	21081	179424911	63774462	37	33977											
DNAH7	56171	broad.mit.edu	37	chr2	196891589	196891589	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtggaactaaatccagtaCgtgttctagccaagaatctt	12	13	8	8	1	2	1	0	0	2	1	3	2	3	2	2	1	3	2	2	1	7	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:196891589C>G	uc002utj.3	-	7	663	c.562G>C	c.(562-564)GTA>CTA	p.V188L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	188	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AAATCCAGTACGTGTTCTAGC	0.353													3	42					0	0	0	0	G	196891589	G	G	196891589	3	3	181	1	0	0	0	0	1	0	0	0	4628	536	19	3	11748	3	DNAH7	2	196891589	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	17466678	196891589	46307784	38	33978											
PSMD1	5707	broad.mit.edu	37	chr2	231947609	231947609	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccttagatcgttagacacGgtggcagtctgggccttggt	6	13	13	9	2	1	2	0	0	1	2	3	2	2	2	2	4	0	2	2	4	2	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:231947609G>A	uc002vrn.1	+	13	1557	c.1426G>A	c.(1426-1428)GGT>AGT	p.G476S	PSMD1_uc002vrm.1_Missense_Mutation_p.G476S|PSMD1_uc010fxu.1_Missense_Mutation_p.G340S	NM_002807	NP_002798	Q99460	PSMD1_HUMAN	proteasome 26S non-ATPase subunit 1	476	PC 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	CGTTAGACACGGTGGCAGTCT	0.373													4	28					0	0	0	0	A	231947609	A	A	231947609	3	1	181	1	0	0	0	0	1	0	0	0	12754	1116	39	1	1476	1	PSMD1	2	231947609	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	35056020	231947609	11251764	39	33979											
RAMP1	10267	broad.mit.edu	37	chr2	238785963	238785963	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccaggtagacatggaggcCgtcggggagacgctgtggtg	7	8	18	8	3	0	2	0	0	0	2	2	4	1	3	2	6	0	2	2	6	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:238785963C>A	uc002vxj.2	+	2	282	c.150C>A	c.(148-150)GCC>GCA	p.A50A		NM_005855	NP_005846	O60894	RAMP1_HUMAN	receptor activity-modifying protein 1 precursor	50	Extracellular (Potential).				intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane	protein transporter activity				0		Breast(86;0.000596)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;9.56e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.49e-11)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.49e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00013)|Lung(119;0.0119)|LUSC - Lung squamous cell carcinoma(224;0.0288)	Pramlintide(DB01278)	ACATGGAGGCCGTCGGGGAGA	0.657													19	61					1.01871e-10	1.09991e-10	1	0	A	238785963	A	A	238785963	2	1	181	1	0	0	0	0	0	0	0	1	13086	639	23	3		3	RAMP1	2	238785963	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	6838354	238785963	4413410	40	33980											
SCLY	51540	broad.mit.edu	37	chr2	239003069	239003069	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatttttttcaggctgaattCggtcagaagagaatccatct	11	15	8	7	1	3	3	2	1	1	2	5	4	4	3	1	2	0	1	1	2	4	5	rs149428035		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:239003069C>T	uc010fyv.2	+	10	1078	c.1014C>T	c.(1012-1014)TTC>TTT	p.F338F	SCLY_uc002vxm.3_Silent_p.F305F|SCLY_uc002vxn.2_3'UTR|SCLY_uc010znq.1_Silent_p.F132F|SCLY_uc010znr.1_Silent_p.F244F|SCLY_uc002vxp.3_5'Flank	NM_016510	NP_057594	Q96I15	SCLY_HUMAN	selenocysteine lyase	338					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			ovary(2)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		AGGCTGAATTCGGTCAGAAGA	0.448													5	93					0	0	0	0	T	239003069	T	T	239003069	2	4	181	1	0	0	0	0	0	0	0	1	13972	883	31	1		1	SCLY	2	239003069	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	217106	239003069	4196304	41	33981											
MYEOV2	150678	broad.mit.edu	37	chr2	241066179	241066179	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacttggattggttcttcCgtaaactgtttcttaagcgt	7	16	9	9	2	2	0	0	0	2	0	3	1	3	1	2	2	2	3	2	2	3	7	rs140948790		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:241066179C>T	uc002vyu.1	-	5	560	c.560G>A	c.(559-561)CGG>CAG	p.R187Q		NM_138336	NP_612209	Q8WXC6	MYOV2_HUMAN	hypothetical protein LOC150678 isoform 1	Error:Variant_position_missing_in_Q8WXC6_after_alignment											0		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		TTGGTTCTTCCGTAAACTGTT	0.483													17	117					0	0	0	0	T	241066179	T	T	241066179	3	4	181	1	0	0	0	0	1	0	0	0	10079	652	23	1	202	1	MYEOV2	2	241066179	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	2063110	241066179	2133194	42	33982											
SNED1	25992	broad.mit.edu	37	chr2	241987826	241987826	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctacgtgtgcgagtgcccCgaaggcttcatgggcctgga	6	8	16	11	3	1	0	1	0	0	0	1	3	1	1	3	4	3	2	3	4	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr2:241987826C>T	uc002wah.1	+	9	1368	c.1368C>T	c.(1366-1368)CCC>CCT	p.P456P		NM_001080437	NP_001073906	Q8TER0	SNED1_HUMAN	6720455I24Rik homolog precursor	456	EGF-like 5.				cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		GCGAGTGCCCCGAAGGCTTCA	0.662													4	9					0	0	0	0	T	241987826	T	T	241987826	2	4	181	1	0	0	0	0	0	0	0	1	14909	639	23	1		1	SNED1	2	241987826	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	921647	241987826	1211547	43	33983											
CAV3	859	broad.mit.edu	37	chr3	8787388	8787388	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgttcgcctgcatctccttCtgccacatctgggcggtggt	3	13	11	14	2	3	0	0	0	3	0	5	0	3	0	3	3	2	2	3	3	0	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:8787388C>T	uc003bra.2	+	2	358	c.291C>T	c.(289-291)TTC>TTT	p.F97F	C3orf32_uc003bqz.2_5'Flank|CAV3_uc003brb.2_Silent_p.F97F	NM_001234	NP_001225	P56539	CAV3_HUMAN	caveolin 3	97	Required for interaction with DAG1.		F -> C (in LQT9; increase in late sodium current).|Missing (in HYPCK).		cell growth|elevation of cytosolic calcium ion concentration|muscle organ development|negative regulation of cardiac muscle hypertrophy|negative regulation of cell size|negative regulation of MAP kinase activity|negative regulation of sarcomere organization|positive regulation of microtubule polymerization|regulation of skeletal muscle contraction|regulation of ventricular cardiomyocyte membrane repolarization|T-tubule organization	caveola|dystrophin-associated glycoprotein complex|Golgi membrane|neuromuscular junction|T-tubule	protein C-terminus binding|protein complex binding|protein complex scaffold|sodium channel regulator activity			lung(1)|breast(1)	2						GCATCTCCTTCTGCCACATCT	0.582													4	15					0	0	0	0	T	8787388	T	T	8787388	2	4	181	1	0	0	0	0	0	0	0	1	2707	912	32	2		2	CAV3	3	8787388	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08		8787388	189235042	44	33984											
CACNA1D	776	broad.mit.edu	37	chr3	53700551	53700551	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatggagggctggacagatGtgctctactgggtaagtacc	9	9	14	9	0	1	1	0	0	1	1	1	3	1	3	2	4	3	4	2	4	3	3	rs148674323		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:53700551G>A	uc003dgv.3	+	7	1268	c.1105G>A	c.(1105-1107)GTG>ATG	p.V369M	CACNA1D_uc003dgu.3_Missense_Mutation_p.V369M|CACNA1D_uc003dgy.3_Missense_Mutation_p.V369M|CACNA1D_uc003dgw.3_Missense_Mutation_p.V16M	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	369	Extracellular (Potential).|I.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CTGGACAGATGTGCTCTACTG	0.512													41	64					0	0	0	0	A	53700551	A	A	53700551	3	1	181	1	0	0	0	0	1	0	0	0	2553	1377	48	4	1131	4	CACNA1D	3	53700551	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	44913163	53700551	144321879	45	33985											
IFT57	55081	broad.mit.edu	37	chr3	107938325	107938325	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcatattcttgaggctgctCaaagggacgtcccgctttat	9	13	9	10	2	3	1	2	1	1	0	4	2	4	2	1	2	1	3	1	2	3	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:107938325C>T	uc003dwx.3	-	2	555	c.307G>A	c.(307-309)GAG>AAG	p.E103K		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	103					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			TGAGGCTGCTCAAAGGGACGT	0.418													6	82					0	0	0	0	T	107938325	T	T	107938325	3	4	181	1	0	0	0	0	1	0	0	0	7601	835	29	2	1022	2	IFT57	3	107938325	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	54237774	107938325	90084105	46	33986											
SLC35A5	55032	broad.mit.edu	37	chr3	112300018	112300018	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtgtctgtcctggtctttGacttcaggccctccctggaa	5	13	10	13	0	3	1	1	1	2	0	5	2	5	2	3	3	0	0	3	3	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:112300018G>C	uc003dze.2	+	6	1299	c.1054G>C	c.(1054-1056)GAC>CAC	p.D352H		NM_017945	NP_060415	Q9BS91	S35A5_HUMAN	solute carrier family 35, member A5	352						Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1						CCTGGTCTTTGACTTCAGGCC	0.453													12	86					0	0	0	0	C	112300018	C	C	112300018	3	2	181	1	0	0	0	0	1	0	0	0	14638	1290	45	2	1072	2	SLC35A5	3	112300018	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	4361693	112300018	85722412	47	33987											
RABL3	285282	broad.mit.edu	37	chr3	120424914	120424914	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttccaatgaccaacgacgcaAgttttgggaggacttcttat	11	12	9	9	2	1	1	0	1	1	0	2	4	2	3	2	2	1	2	2	2	4	5	rs151038439		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:120424914A>C	uc003edx.2	-	4	346	c.316T>G	c.(316-318)TTG>GTG	p.L106V		NM_173825	NP_776186	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3	106	Small GTPase-like.				small GTPase mediated signal transduction		GTP binding				0				GBM - Glioblastoma multiforme(114;0.151)		CAACGACGCAAGTTTTGGGAG	0.383													10	39					0	0	0	0	C	120424914	C	C	120424914	3	2	181	1	0	0	0	0	1	0	0	0	13037	69	3	5	414	5	RABL3	3	120424914	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08	8124896	120424914	77597516	48	33988											
DTX3L	151636	broad.mit.edu	37	chr3	122287708	122287708	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgataaaatcaactcaataGagaaaagatttggtgtaaac	19	10	7	5	0	2	3	2	1	0	2	2	4	2	3	0	1	2	1	0	1	9	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:122287708G>C	uc003efk.2	+	3	861	c.772G>C	c.(772-774)GAG>CAG	p.E258Q	DTX3L_uc010hrj.2_Intron	NM_138287	NP_612144	Q8TDB6	DTX3L_HUMAN	deltex 3-like	258					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)	4				GBM - Glioblastoma multiforme(114;0.0459)		CAACTCAATAGAGAAAAGATT	0.373													3	33					0	0	0	0	C	122287708	C	C	122287708	3	2	181	1	0	0	0	0	1	0	0	0	4818	943	33	2	782	2	DTX3L	3	122287708	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	1862794	122287708	75734722	49	33989											
CLSTN2	64084	broad.mit.edu	37	chr3	140167508	140167508	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cattgggaagggttgtgaccGggagacctactctgagaaat	11	9	14	7	1	1	3	0	2	1	2	1	6	1	4	2	3	1	1	2	3	3	3	rs148820533		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:140167508G>A	uc003etn.2	+	6	1125	c.935G>A	c.(934-936)CGG>CAG	p.R312Q	CLSTN2_uc003etm.2_Missense_Mutation_p.R312Q	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	312	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GGTTGTGACCGGGAGACCTAC	0.443										HNSCC(16;0.037)			22	236					0	0	0	0	A	140167508	A	A	140167508	3	1	181	1	0	0	0	0	1	0	0	0	3577	1116	39	1	957	1	CLSTN2	3	140167508	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	17879800	140167508	57854922	50	33990											
FAM194A	131831	broad.mit.edu	37	chr3	150377925	150377925	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtatcggaggattggaatCtcctcagggtttggtagctt	8	13	13	7	2	2	0	1	0	1	0	4	3	2	3	1	5	1	4	1	5	3	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:150377925C>T	uc003eyg.2	-	14	1803	c.1746G>A	c.(1744-1746)GAG>GAA	p.E582E	FAM194A_uc003eyh.2_Silent_p.E436E	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	582										skin(2)|ovary(1)	3						GGATTGGAATCTCCTCAGGGT	0.463													10	129					0	0	0	0	T	150377925	T	T	150377925	2	4	181	1	0	0	0	0	0	0	0	1	5554	912	32	2		2	FAM194A	3	150377925	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	10210417	150377925	47644505	51	33991											
MED12L	116931	broad.mit.edu	37	chr3	150908657	150908657	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactgcctcaactcggccgcGgtcaccagtaggggaaaatg	10	6	12	13	3	2	0	2	0	0	0	3	1	2	1	3	4	2	1	3	4	4	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:150908657G>A	uc003eyp.2	+	13	1945	c.1907G>A	c.(1906-1908)CGG>CAG	p.R636Q	MED12L_uc011bnz.1_Missense_Mutation_p.R496Q|MED12L_uc003eyn.2_Missense_Mutation_p.R636Q|MED12L_uc003eyo.2_Missense_Mutation_p.R636Q	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	636					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACTCGGCCGCGGTCACCAGTA	0.502													7	62					0	0	0	0	A	150908657	A	A	150908657	3	1	181	1	0	0	0	0	1	0	0	0	9482	1116	39	1	1957	1	MED12L	3	150908657	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	530732	150908657	47113773	52	33992											
MED12L	116931	broad.mit.edu	37	chr3	151129190	151129190	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agcctatccggccgcacattCcaaccccgtgctaatggaaa	11	7	8	15	3	0	0	0	0	0	0	2	1	2	1	6	2	3	2	6	2	4	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:151129190C>G	uc003eyp.2	+	39	5968	c.5930C>G	c.(5929-5931)TCC>TGC	p.S1977C	MED12L_uc011bnz.1_Intron	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1977	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCCGCACATTCCAACCCCGTG	0.582													13	139					0	0	0	0	G	151129190	G	G	151129190	3	3	181	1	0	0	0	0	1	0	0	0	9482	855	30	2	6084	2	MED12L	3	151129190	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	220533	151129190	46893240	53	33993											
KCNAB1	7881	broad.mit.edu	37	chr3	156175266	156175266	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacggctgatgaccatcGcctatgaaagtggtgttaac	11	10	11	9	2	0	4	0	4	0	0	1	4	0	4	2	2	2	2	2	2	4	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:156175266G>A	uc003far.2	+	4	446	c.382G>A	c.(382-384)GCC>ACC	p.A128T	KCNAB1_uc011bon.1_Missense_Mutation_p.A128T|KCNAB1_uc003fas.2_Missense_Mutation_p.A117T|KCNAB1_uc003fat.2_Missense_Mutation_p.A110T|KCNAB1_uc010hvt.1_Missense_Mutation_p.A110T|KCNAB1_uc011boo.1_Missense_Mutation_p.A4T	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	128						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GATGACCATCGCCTATGAAAG	0.473													17	152					0	0	0	0	A	156175266	A	A	156175266	3	1	181	1	0	0	0	0	1	0	0	0	8048	1087	38	1	867	1	KCNAB1	3	156175266	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	5046076	156175266	41847164	54	33994											
ECT2	1894	broad.mit.edu	37	chr3	172474799	172474799	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagtgggctttgtaaagatGgagtcagtggaagaatttga	14	11	14	2	0	1	3	1	1	0	2	1	5	1	5	0	3	0	2	0	3	5	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:172474799G>A	uc003fii.2	+	4	375	c.237G>A	c.(235-237)ATG>ATA	p.M79I	ECT2_uc010hwv.1_Missense_Mutation_p.M110I|ECT2_uc003fih.2_Missense_Mutation_p.M78I|ECT2_uc003fij.1_Missense_Mutation_p.M79I|ECT2_uc003fik.1_Missense_Mutation_p.M79I|ECT2_uc003fil.1_Missense_Mutation_p.M110I	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	79					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			TTGTAAAGATGGAGTCAGTGG	0.328													74	107					0	0	0	0	A	172474799	A	A	172474799	3	1	181	1	0	0	0	0	1	0	0	0	4923	1348	47	4	247	4	ECT2	3	172474799	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	16299533	172474799	25547631	55	33995											
MAP3K13	9175	broad.mit.edu	37	chr3	185198087	185198087	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgagaatttctctgtgtctGatggagaagagggaaatacc	12	11	12	6	0	2	4	0	2	2	3	3	7	2	5	1	2	1	0	1	2	4	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:185198087G>C	uc010hyf.2	+	14	2835	c.2569G>C	c.(2569-2571)GAT>CAT	p.D857H	MAP3K13_uc011brt.1_Missense_Mutation_p.D650H|MAP3K13_uc011bru.1_Missense_Mutation_p.D713H|MAP3K13_uc003fpi.2_Missense_Mutation_p.D857H|MAP3K13_uc010hyg.2_Missense_Mutation_p.D547H	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	857					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			CTCTGTGTCTGATGGAGAAGA	0.473													16	141					0	0	0	0	C	185198087	C	C	185198087	3	2	181	1	0	0	0	0	1	0	0	0	9300	1290	45	2	2615	2	MAP3K13	3	185198087	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	12723288	185198087	12824343	56	33996											
MUC4	4585	broad.mit.edu	37	chr3	195481222	195481222	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagcggccgaaggtgccccCgtcacacttgcagccagcca	8	5	12	16	3	1	0	1	0	0	0	1	1	1	0	5	2	5	2	5	2	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr3:195481222C>T	uc011bto.1	-	20	15266	c.14806G>A	c.(14806-14808)GGG>AGG	p.G4936R	MUC4_uc010hzq.2_5'Flank|MUC4_uc003fuz.2_Missense_Mutation_p.G662R|MUC4_uc003fva.2_Missense_Mutation_p.G544R|MUC4_uc003fvb.2_Missense_Mutation_p.G580R|MUC4_uc003fvc.2_Intron|MUC4_uc003fvd.2_Intron|MUC4_uc003fve.2_Missense_Mutation_p.G580R|MUC4_uc010hzr.2_Intron|MUC4_uc011btf.1_Missense_Mutation_p.G544R|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Missense_Mutation_p.G628R|MUC4_uc011bti.1_Missense_Mutation_p.G628R|MUC4_uc011btj.1_Missense_Mutation_p.G805R|MUC4_uc011btk.1_Missense_Mutation_p.G544R|MUC4_uc011btl.1_Missense_Mutation_p.G573R|MUC4_uc011btm.1_Missense_Mutation_p.G753R|MUC4_uc011btn.1_Missense_Mutation_p.G544R|MUC4_uc003fvo.2_Missense_Mutation_p.G828R|MUC4_uc003fvp.2_Missense_Mutation_p.G777R	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1821					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AAGGTGCCCCCGTCACACTTG	0.652													25	44					0	0	0	0	T	195481222	T	T	195481222	3	4	181	1	0	0	0	0	1	0	0	0	10031	652	23	1	1076	1	MUC4	3	195481222	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	10283135	195481222	2541208	57	33997											
WHSC2	7469	broad.mit.edu	37	chr4	1985365	1985365	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caggatgagggccttctcggGccgcgtgactttgttggccg	4	10	16	11	4	1	2	0	2	1	0	2	3	1	3	3	4	0	1	3	4	0	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr4:1985365G>A	uc003gem.2	-	10	1633	c.1393C>T	c.(1393-1395)CCC>TCC	p.P465S	WHSC2_uc003gek.2_Missense_Mutation_p.P191S|WHSC2_uc003gel.2_Missense_Mutation_p.P379S|WHSC2_uc003gen.2_Missense_Mutation_p.P319S	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	454					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)			GCCTTCTCGGGCCGCGTGACT	0.677													11	26					0	0	0	0	A	1985365	A	A	1985365	3	1	181	1	0	0	0	0	1	0	0	0	17432	1203	42	4	234	4	WHSC2	4	1985365	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08		1985365	189168911	58	33998											
C4orf6	10141	broad.mit.edu	37	chr4	5528029	5528029	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accccagtgtgactgtctccGgtgctcactcaactgcagtg	7	10	10	14	1	3	1	2	1	1	0	4	1	3	1	3	1	3	2	3	1	1	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr4:5528029G>A	uc003gii.2	+	2	428	c.253G>A	c.(253-255)GGT>AGT	p.G85S		NM_005750	NP_005741	Q99440	CD006_HUMAN	chromosome 4 open reading frame 6	85					nervous system development						0						GACTGTCTCCGGTGCTCACTC	0.438													6	40					0	0	0	0	A	5528029	A	A	5528029	3	1	181	1	0	0	0	0	1	0	0	0	2288	1116	39	1	259	1	C4orf6	4	5528029	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	3542664	5528029	185626247	59	33999											
EVC2	132884	broad.mit.edu	37	chr4	5624705	5624705	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgacggacgcctgctccctaCgctgctccctgtgctggagt	4	9	12	16	4	0	0	0	0	0	0	2	3	2	2	3	2	4	4	3	2	1	1	rs144420242	byFrequency	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr4:5624705C>T	uc003gij.2	-	14	2114	c.2060G>A	c.(2059-2061)CGT>CAT	p.R687H	EVC2_uc011bwb.1_Missense_Mutation_p.R127H|EVC2_uc003gik.2_Missense_Mutation_p.R607H	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	687	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						CTGCTCCCTACGCTGCTCCCT	0.592													10	29					0	0	0	0	T	5624705	T	T	5624705	3	4	181	1	0	0	0	0	1	0	0	0	5310	536	19	1	1902	1	EVC2	4	5624705	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	96676	5624705	185529571	60	34000											
C4orf50	389197	broad.mit.edu	37	chr4	5961120	5961120	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tattacatttctaactccagCggtgatttatggacctggga	10	14	9	8	1	1	1	0	1	1	0	2	3	2	3	2	3	3	0	2	3	4	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr4:5961120C>T	uc003git.1	-	7	903	c.813G>A	c.(811-813)CCG>CCA	p.P271P		NM_207405	NP_997288	Q6ZRC1	CD050_HUMAN	hypothetical protein LOC389197	271										pancreas(2)|breast(1)	3						CTAACTCCAGCGGTGATTTAT	0.458													16	100					0	0	0	0	T	5961120	T	T	5961120	2	4	181	1	0	0	0	0	0	0	0	1	2286	755	27	1		1	C4orf50	4	5961120	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	336415	5961120	185193156	61	34001											
CSN3	1448	broad.mit.edu	37	chr4	71114847	71114847	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagctatagcaattaataatCcatatgtgcctcgcacatat	14	12	5	10	1	0	0	0	0	0	0	2	0	1	0	2	0	3	3	2	0	7	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr4:71114847C>G	uc003hfe.3	+	4	278	c.220C>G	c.(220-222)CCA>GCA	p.P74A		NM_005212	NP_005203	P07498	CASK_HUMAN	casein kappa precursor	74						extracellular region	protein binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						AATTAATAATCCATATGTGCC	0.433													8	56					0	0	0	0	G	71114847	G	G	71114847	3	3	181	1	0	0	0	0	1	0	0	0	3966	855	30	2	230	2	CSN3	4	71114847	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	65153727	71114847	120039429	62	34002											
GK2	2712	broad.mit.edu	37	chr4	80327860	80327860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttcttccatgtggcataacGaatttcactttctgtggcct	7	17	7	10	1	3	0	1	0	2	0	4	1	4	0	2	2	1	1	2	2	2	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr4:80327860G>A	uc003hlu.2	-	1	1513	c.1495C>T	c.(1495-1497)CGT>TGT	p.R499C		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	499				R -> C (in Ref. 2; BAF84930).	glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						GTGGCATAACGAATTTCACTT	0.478													12	77					0	0	0	0	A	80327860	A	A	80327860	3	1	181	1	0	0	0	0	1	0	0	0	6458	1058	37	1	170	1	GK2	4	80327860	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	9213013	80327860	110826416	63	34003											
GRID2	2895	broad.mit.edu	37	chr4	94377124	94377124	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatggatcttttgtacaacaAggtaaggagcaaaagtacat	16	11	9	5	0	1	0	0	0	1	0	1	2	1	2	0	3	4	4	0	3	8	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr4:94377124A>C	uc011cdt.1	+	11	2115	c.1857A>C	c.(1855-1857)CAA>CAC	p.Q619H	GRID2_uc011cdu.1_Missense_Mutation_p.Q524H	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	619	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TTGTACAACAAGGTAAGGAGC	0.353													11	50					0	0	0	0	C	94377124	C	C	94377124	3	2	181	1	0	0	0	0	1	0	0	0	6811	86	3	5	1899	5	GRID2	4	94377124	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08	14049264	94377124	96777152	64	34004											
INTU	27152	broad.mit.edu	37	chr4	128627931	128627931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaacttctccaacatgcaGaagaacgctttttggtgact	12	11	8	10	1	1	3	0	1	1	2	2	3	1	3	1	1	5	3	1	1	4	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr4:128627931G>A	uc003ifk.1	+	12	2148	c.2078G>A	c.(2077-2079)AGA>AAA	p.R693K	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	693										ovary(1)	1						CCAACATGCAGAAGAACGCTT	0.438													18	85					0	0	0	0	A	128627931	A	A	128627931	3	1	181	1	0	0	0	0	1	0	0	0	7825	942	33	2	2124	2	INTU	4	128627931	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	34250807	128627931	62526345	65	34005											
INTU	27152	broad.mit.edu	37	chr4	128628077	128628077	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcagtacggaagcaaagaGaatctcagggctctgatggt	13	8	13	7	1	2	2	1	1	2	1	3	4	2	3	0	3	3	4	0	3	4	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr4:128628077G>A	uc003ifk.1	+	12	2294	c.2224G>A	c.(2224-2226)GAA>AAA	p.E742K	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	742										ovary(1)	1						GAAGCAAAGAGAATCTCAGGG	0.473													22	119					0	0	0	0	A	128628077	A	A	128628077	3	1	181	1	0	0	0	0	1	0	0	0	7825	943	33	2	2270	2	INTU	4	128628077	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	146	128628077	62526199	66	34006											
MAP9	79884	broad.mit.edu	37	chr4	156281422	156281422	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ataatcagttccgcttttgcCttttcttcttcaaggtcatc	7	18	5	11	1	5	0	3	0	2	0	7	0	6	0	2	1	1	2	2	1	2	8			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr4:156281422C>A	uc003ios.2	-	7	1212	c.948G>T	c.(946-948)AAG>AAT	p.K316N	MAP9_uc011cin.1_Missense_Mutation_p.K291N|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.K315N	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	316	Potential.				cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CCGCTTTTGCCTTTTCTTCTT	0.378													9	50					2.74318e-10	2.94053e-10	1	0	A	156281422	A	A	156281422	3	1	181	1	0	0	0	0	1	0	0	0	9323	680	24	4	1027	4	MAP9	4	156281422	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	27653345	156281422	34872854	67	34007											
SEMA5A	9037	broad.mit.edu	37	chr5	9119159	9119159	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcccccgtgcctgggagTggggttgctgcaggagcgct	3	7	18	13	3	0	0	0	0	0	0	0	2	0	2	4	5	4	4	4	5	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:9119159T>C	uc003jek.2	-	15	2588	c.1876A>G	c.(1876-1878)ACT>GCT	p.T626A		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	626	TSP type-1 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TGCCTGGGAGTGGGGTTGCTG	0.667													9	38					0	0	0	0	C	9119159	C	C	9119159	3	2	181	1	0	0	0	0	1	0	0	0	14102	1696	59	5	1384	5	SEMA5A	5	9119159	Missense_Mutation	SNP	T	TCGA-CV-5970-01A-11D-1683-08		9119159	171796101	68	34008											
MARCH6	10299	broad.mit.edu	37	chr5	10407240	10407240	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggctccattgtcctcctGatgctttggcttcctatacg	4	17	8	12	1	0	1	0	1	0	0	4	1	4	1	4	2	2	3	4	2	2	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:10407240G>A	uc003jet.1	+	17	1662	c.1479G>A	c.(1477-1479)CTG>CTA	p.L493L	MARCH6_uc011cmu.1_Silent_p.L445L|MARCH6_uc003jeu.1_Silent_p.L191L|MARCH6_uc011cmv.1_Silent_p.L388L	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	493	Helical; (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						TTGTCCTCCTGATGCTTTGGC	0.408													26	293					0	0	0	0	A	10407240	A	A	10407240	2	1	181	1	0	0	0	0	0	0	0	1	9358	1277	45	2		2	MARCH6	5	10407240	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	1288081	10407240	170508020	69	34009											
PRDM9	56979	broad.mit.edu	37	chr5	23527576	23527576	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gataagtcaaacctcctcagTcaccagaggacacacacagg	15	5	8	13	0	3	1	3	0	0	1	4	3	4	2	3	2	1	0	3	2	2	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:23527576T>A	uc003jgo.2	+	11	2561	c.2379T>A	c.(2377-2379)AGT>AGA	p.S793R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	793	C2H2-type 11.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ACCTCCTCAGTCACCAGAGGA	0.562										HNSCC(3;0.000094)			5	154					0	0	0	0	A	23527576	A	A	23527576	3	1	181	1	0	0	0	0	1	0	0	0	12525	1664	58	5	2417	5	PRDM9	5	23527576	Missense_Mutation	SNP	T	TCGA-CV-5970-01A-11D-1683-08	13120336	23527576	157387684	70	34010											
TARS	6897	broad.mit.edu	37	chr5	33448677	33448677	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctgaatatatttacacaCgtcttgagatgtataatata	14	14	7	6	1	1	2	0	2	1	1	1	3	1	2	1	1	1	1	1	1	8	9			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:33448677C>T	uc003jhy.2	+	3	464	c.169C>T	c.(169-171)CGT>TGT	p.R57C	TARS_uc011cob.1_Missense_Mutation_p.R45C|TARS_uc010iup.1_Translation_Start_Site|TARS_uc011coc.1_Missense_Mutation_p.R45C|TARS_uc003jhz.2_Intron|TARS_uc011cod.1_Translation_Start_Site	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	57					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	TATTTACACACGTCTTGAGAT	0.343													8	85					0	0	0	0	T	33448677	T	T	33448677	3	4	181	1	0	0	0	0	1	0	0	0	15625	536	19	1	179	1	TARS	5	33448677	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	9921101	33448677	147466583	71	34011											
SLC1A3	6507	broad.mit.edu	37	chr5	36686248	36686248	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacttgtcacgacatgaactGaagaacagagatgttgaaat	16	9	9	7	1	1	5	1	3	0	2	1	7	1	5	0	0	2	1	0	0	4	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:36686248G>A	uc003jkj.3	+	10	1982	c.1506G>A	c.(1504-1506)CTG>CTA	p.L502L	SLC1A3_uc011cox.1_Silent_p.L395L|SLC1A3_uc010iuy.2_Silent_p.L457L	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	502					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	GACATGAACTGAAGAACAGAG	0.498													20	198					0	0	0	0	A	36686248	A	A	36686248	2	1	181	1	0	0	0	0	0	0	0	1	14498	1277	45	2		2	SLC1A3	5	36686248	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	3237571	36686248	144229012	72	34012											
C5orf42	65250	broad.mit.edu	37	chr5	37108457	37108457	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttctgaaggtatcgtccaggGactcaccacagtctcctctc	8	11	8	14	1	4	1	1	1	3	0	8	2	5	2	3	2	0	1	3	2	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:37108457G>A	uc011cpa.1	-	51	9586	c.9355C>T	c.(9355-9357)CCC>TCC	p.P3119S	C5orf42_uc003jko.1_Missense_Mutation_p.P150S|C5orf42_uc003jkp.1_RNA|C5orf42_uc011coy.1_Missense_Mutation_p.P1637S|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.P2212S	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	3119										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ATCGTCCAGGGACTCACCACA	0.423													6	91					0	0	0	0	A	37108457	A	A	37108457	3	1	181	1	0	0	0	0	1	0	0	0	2311	1174	41	2	246	2	C5orf42	5	37108457	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	422209	37108457	143806803	73	34013											
MAST4	375449	broad.mit.edu	37	chr5	66398375	66398375	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttgcagccctggacgttCtcccgcctgctgtgaccatg	4	11	11	15	2	1	1	0	1	1	0	2	2	1	2	4	1	4	4	4	1	0	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:66398375C>T	uc003jut.1	+	8	583	c.515C>T	c.(514-516)TCT>TTT	p.S172F	MAST4_uc003jus.2_Missense_Mutation_p.S172F|MAST4_uc003juu.1_Missense_Mutation_p.S182F|MAST4_uc011cra.1_Missense_Mutation_p.S155F|MAST4_uc010ixa.2_RNA|MAST4_uc003juv.2_Missense_Mutation_p.S167F|MAST4_uc003juw.2_Missense_Mutation_p.S167F	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	364						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CCTGGACGTTCTCCCGCCTGC	0.373													16	59					0	0	0	0	T	66398375	T	T	66398375	3	4	181	1	0	0	0	0	1	0	0	0	9380	913	32	2	1246	2	MAST4	5	66398375	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	29289918	66398375	114516885	74	34014											
TAF9	6880	broad.mit.edu	37	chr5	68660814	68660814	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcatcatcgtcatcatcatCatcttcacgttttcttttca	9	18	2	12	2	10	0	8	0	2	0	11	0	10	0	0	0	0	1	0	0	0	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:68660814C>T	uc003jwc.1	-	2	1083	c.751G>A	c.(751-753)GAT>AAT	p.D251N	TAF9_uc003jwa.2_Intron|TAF9_uc003jwb.2_Intron|TAF9_uc003jwd.1_Missense_Mutation_p.D251N|TAF9_uc003jwe.1_Missense_Mutation_p.D251N|TAF9_uc003jwf.1_Missense_Mutation_p.D251N	NM_003187	NP_003178	Q16594	TAF9_HUMAN	TAF9 RNA polymerase II, TATA box binding	251	Poly-Asp.				histone H3 acetylation|negative regulation of apoptosis|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cell growth|positive regulation of response to cytokine stimulus|positive regulation of transcription from RNA polymerase II promoter|response to interleukin-1|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	MLL1 complex|PCAF complex|pre-snoRNP complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	activating transcription factor binding|C2H2 zinc finger domain binding|p53 binding|transcription coactivator activity|transcription regulatory region DNA binding				0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		tcatcatcatcatcttcaCGT	0.249													7	49					0	0	0	0	T	68660814	T	T	68660814	3	4	181	1	0	0	0	0	1	0	0	0	15601	826	29	2	457	2	TAF9	5	68660814	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	2262439	68660814	112254446	75	34015											
DMGDH	29958	broad.mit.edu	37	chr5	78338269	78338269	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgatgtgttccatgattcGatctagatcagactcaaaga	12	14	8	7	1	3	5	2	2	1	3	5	6	4	5	1	0	0	1	1	0	2	4	rs143021634	byFrequency	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:78338269G>A	uc003kfs.2	-	7	1036	c.1030C>T	c.(1030-1032)CGA>TGA	p.R344*	DMGDH_uc011cte.1_Nonsense_Mutation_p.R194*|DMGDH_uc011ctf.1_Nonsense_Mutation_p.R143*|DMGDH_uc011ctg.1_Intron	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	344					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TCCATGATTCGATCTAGATCA	0.423													11	64					0	0	0	0	A	78338269	A	A	78338269	4	1	181	1	0	0	0	0	0	1	0	0	4603	1066	37	1	1610	1	DMGDH	5	78338269	Nonsense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	9677455	78338269	102576991	76	34016											
LNPEP	4012	broad.mit.edu	37	chr5	96314937	96314937	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagagccttgtttacatcctCtagagcctgatgaggtggaa	11	11	11	8	0	1	4	0	2	1	2	2	5	2	5	3	2	3	1	3	2	4	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:96314937C>G	uc003kmv.1	+	2	629	c.115C>G	c.(115-117)CTA>GTA	p.L39V	LNPEP_uc003kmw.1_Missense_Mutation_p.L25V	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	39	Cytoplasmic (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		TTTACATCCTCTAGAGCCTGA	0.498													11	74					0	0	0	0	G	96314937	G	G	96314937	3	3	181	1	0	0	0	0	1	0	0	0	8906	912	32	2	121	2	LNPEP	5	96314937	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	17976668	96314937	84600323	77	34017											
FSTL4	23105	broad.mit.edu	37	chr5	132652228	132652228	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagagattccaccaggaggcGcttctgggaggcagggtctt	8	8	15	10	1	2	1	0	0	2	1	3	4	3	3	2	5	0	2	2	5	0	3	rs139711882	byFrequency	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:132652228G>A	uc003kyn.1	-	5	744	c.526C>T	c.(526-528)CGC>TGC	p.R176C		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	176	EF-hand.					extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACCAGGAGGCGCTTCTGGGAG	0.587											OREG0016777	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	38					0	0	0	0	A	132652228	A	A	132652228	3	1	181	1	0	0	0	0	1	0	0	0	6113	1087	38	1	2050	1	FSTL4	5	132652228	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	36337291	132652228	48263032	78	34018											
PCDHGB4	8641	broad.mit.edu	37	chr5	140769023	140769023	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgaccacgagcagctgcgCgccttcgaactcacactgca	9	7	9	16	5	1	0	1	0	0	0	3	3	1	0	2	0	5	3	2	0	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:140769023C>T	uc003lkc.1	+	1	1572	c.1572C>T	c.(1570-1572)CGC>CGT	p.R524R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.R524R	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	524	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAGCTGCGCGCCTTCGAAC	0.672													21	39					0	0	0	0	T	140769023	T	T	140769023	2	4	181	1	0	0	0	0	0	0	0	1	11619	755	27	1		1	PCDHGB4	5	140769023	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	8116795	140769023	40146237	79	34019											
PCDHGB4	8641	broad.mit.edu	37	chr5	140769043	140769043	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccttcgaactcacactgcAggcccgcgaccagggctcgc	7	5	11	18	5	1	0	1	0	0	0	3	2	1	0	3	2	2	2	3	2	1	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:140769043A>T	uc003lkc.1	+	1	1592	c.1592A>T	c.(1591-1593)CAG>CTG	p.Q531L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.Q531L	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	531	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCACACTGCAGGCCCGCGAC	0.677													18	31					0	0	0	0	T	140769043	T	T	140769043	3	4	181	1	0	0	0	0	1	0	0	0	11619	188	7	5	1594	5	PCDHGB4	5	140769043	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08	20	140769043	40146217	80	34020											
TTC1	7265	broad.mit.edu	37	chr5	159437549	159437549	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcagcatgggggagaagtCagagaactgtggggttccag	10	6	19	6	0	1	2	1	0	0	2	2	4	2	2	1	5	2	3	1	5	2	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr5:159437549C>T	uc003lxu.2	+	2	64	c.14C>T	c.(13-15)TCA>TTA	p.S5L		NM_003314	NP_003305	Q99614	TTC1_HUMAN	tetratricopeptide repeat domain 1	5					protein folding		unfolded protein binding			skin(1)	1	Renal(175;0.00196)	all_hematologic(541;0.00014)|Breast(839;0.0101)|all_neural(177;0.0281)|Medulloblastoma(196;0.0425)|Lung NSC(249;0.119)|all_lung(500;0.163)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	Epithelial(171;8.37e-05)|all cancers(165;0.000694)|OV - Ovarian serous cystadenocarcinoma(192;0.0402)		GGGGAGAAGTCAGAGAACTGT	0.463													7	44					0	0	0	0	T	159437549	T	T	159437549	3	4	181	1	0	0	0	0	1	0	0	0	16746	838	29	2	16	2	TTC1	5	159437549	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	18668506	159437549	21477711	81	34021											
OR2H2	7932	broad.mit.edu	37	chr6	29556072	29556072	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcctcttgacagtgatggcTtttgatcgctacgtggctgt	6	15	11	9	2	1	3	0	3	1	0	3	3	2	3	1	2	1	3	1	2	1	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr6:29556072T>C	uc003nmr.1	+	1	390	c.351T>C	c.(349-351)GCT>GCC	p.A117A	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	117	Helical; Name=3; (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAGTGATGGCTTTTGATCGCT	0.587													3	86					0	0	0	0	C	29556072	C	C	29556072	2	2	181	1	0	0	0	0	0	0	0	1	11056	1596	56	5		5	OR2H2	6	29556072	Silent	SNP	T	TCGA-CV-5970-01A-11D-1683-08		29556072	141558995	82	34022											
PACSIN1	29993	broad.mit.edu	37	chr6	34499521	34499521	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcgcgtgcgggcactctaCgactatgacggccaggagca	8	6	15	12	5	1	1	0	1	1	0	1	3	1	2	1	3	4	2	1	3	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr6:34499521C>T	uc003ojo.2	+	9	1388	c.1182C>T	c.(1180-1182)TAC>TAT	p.Y394Y	PACSIN1_uc003ojp.2_Silent_p.Y394Y	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	394	SH3.				endocytosis		protein kinase activity				0						GGGCACTCTACGACTATGACG	0.647													30	135					0	0	0	0	T	34499521	T	T	34499521	2	4	181	1	0	0	0	0	0	0	0	1	11428	547	19	1		1	PACSIN1	6	34499521	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	4943449	34499521	136615546	83	34023											
ZNF76	7629	broad.mit.edu	37	chr6	35260716	35260716	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccggatagcttacctttcGgaggtgaaggaagagagaga	12	7	14	8	2	0	3	0	1	0	2	1	8	0	6	3	4	2	1	3	4	4	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr6:35260716G>A	uc003oki.1	+	11	1429	c.1224G>A	c.(1222-1224)TCG>TCA	p.S408S	ZNF76_uc003okj.1_Silent_p.S408S	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	408					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTACCTTTCGGAGGTGAAGG	0.612													55	55					0	0	0	0	A	35260716	A	A	35260716	2	1	181	1	0	0	0	0	0	0	0	1	18202	1103	39	1		1	ZNF76	6	35260716	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	761195	35260716	135854351	84	34024											
CPNE5	57699	broad.mit.edu	37	chr6	36714277	36714277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctggatgatctctccgaCggcagtcagcgccagcgcgt	6	8	14	13	5	2	1	1	1	1	0	4	3	3	2	2	2	3	2	2	2	0	0	rs150078502	byFrequency	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr6:36714277C>T	uc003omr.1	-	16	1163	c.1096G>A	c.(1096-1098)GTC>ATC	p.V366I	CPNE5_uc003omp.1_Missense_Mutation_p.V74I|CPNE5_uc010jwn.1_Missense_Mutation_p.V16I|CPNE5_uc003omq.1_Missense_Mutation_p.V16I	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V	366	VWFA.									skin(1)	1						ATCTCTCCGACGGCAGTCAGC	0.622													4	59					0	0	0	0	T	36714277	T	T	36714277	3	4	181	1	0	0	0	0	1	0	0	0	3830	536	19	1	709	1	CPNE5	6	36714277	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	1453561	36714277	134400790	85	34025											
ZNF292	23036	broad.mit.edu	37	chr6	87966228	87966228	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagaaaactcaactgtggaaGgcagtggtgaagcactggtc	14	7	13	7	0	1	2	1	1	0	1	2	3	1	3	0	4	3	2	0	4	6	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr6:87966228G>A	uc003plm.3	+	8	2922	c.2881G>A	c.(2881-2883)GGC>AGC	p.G961S		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	961					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		AACTGTGGAAGGCAGTGGTGA	0.428													18	47					0	0	0	0	A	87966228	A	A	87966228	3	1	181	1	0	0	0	0	1	0	0	0	17893	1000	35	4	2911	4	ZNF292	6	87966228	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	51251951	87966228	83148839	86	34026											
C6orf165	154313	broad.mit.edu	37	chr6	88126412	88126412	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacagagtgtttttcctcaGgcagagcttgggacatttct	8	14	10	9	0	2	2	1	0	1	2	3	3	3	3	1	2	2	3	1	2	1	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr6:88126412G>A	uc003plv.2	+	6	590	c.498G>A	c.(496-498)CAG>CAA	p.Q166Q	C6orf165_uc003plw.2_5'UTR|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Silent_p.Q166Q	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	166										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TTTTTCCTCAGGCAGAGCTTG	0.338													25	12					0	0	0	0	A	88126412	A	A	88126412	2	1	181	1	0	0	0	0	0	0	0	1	2351	991	35	4		4	C6orf165	6	88126412	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	160184	88126412	82988655	87	34027											
GOPC	57120	broad.mit.edu	37	chr6	117890830	117890830	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atccccaacgtgcagccctcCgcatctatcagcaggttgcc	8	8	8	17	2	2	0	1	0	1	0	4	0	4	0	5	1	5	4	5	1	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr6:117890830C>T	uc003pxu.2	-	7	1212	c.982G>A	c.(982-984)GGA>AGA	p.G328R	GOPC_uc003pxq.1_Missense_Mutation_p.G101R|DCBLD1_uc003pxs.2_3'UTR|GOPC_uc003pxv.2_Missense_Mutation_p.G320R	NM_020399	NP_065132	Q9HD26	GOPC_HUMAN	golgi associated PDZ and coiled-coil motif	328	PDZ.				apical protein localization|cytoplasmic sequestering of CFTR protein|ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein homooligomerization|protein transport	cell junction|dendrite|Golgi membrane|postsynaptic density|postsynaptic membrane|trans-Golgi network transport vesicle	cystic fibrosis transmembrane conductance regulator binding			ovary(1)	1		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)		TGCAGCCCTCCGCATCTATCA	0.458			O	ROS1	glioblastoma								31	96					0	0	0	0	T	117890830	T	T	117890830	3	4	181	1	0	0	0	0	1	0	0	0	6610	661	23	1	418	1	GOPC	6	117890830	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	29764418	117890830	53224237	88	34028											
EYA4	2070	broad.mit.edu	37	chr6	133783571	133783571	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcagccagccgtctacaCagcctactcacagacaggac	12	4	9	16	1	2	1	1	0	1	1	2	2	2	2	3	1	6	2	3	1	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr6:133783571C>A	uc003qec.3	+	8	994	c.536C>A	c.(535-537)ACA>AAA	p.T179K	EYA4_uc011ecq.1_Missense_Mutation_p.T125K|EYA4_uc011ecr.1_Missense_Mutation_p.T125K|EYA4_uc003qed.3_Missense_Mutation_p.T179K|EYA4_uc003qee.3_Missense_Mutation_p.T156K|EYA4_uc011ecs.1_Missense_Mutation_p.T179K|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	179					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		GCCGTCTACACAGCCTACTCA	0.507													9	55					0.000274275	0.000281841	1	0	A	133783571	A	A	133783571	3	1	181	1	0	0	0	0	1	0	0	0	5356	478	17	4	562	4	EYA4	6	133783571	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	15892741	133783571	37331496	89	34029											
SDK1	221935	broad.mit.edu	37	chr7	4272924	4272924	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtttgtgaaggacatcccGcggagcgccacatcctacac	10	8	10	13	3	0	1	0	1	0	0	2	3	2	3	3	2	2	1	3	2	2	2	rs144472783		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:4272924G>A	uc003smx.2	+	41	6004	c.5865G>A	c.(5863-5865)CCG>CCA	p.P1955P	SDK1_uc010kso.2_Silent_p.P1211P|SDK1_uc003smy.2_Silent_p.P442P|SDK1_uc003smz.2_Silent_p.P15P	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1955	Fibronectin type-III 13.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGGACATCCCGCGGAGCGCCA	0.597													10	50					0	0	0	0	A	4272924	A	A	4272924	2	1	181	1	0	0	0	0	0	0	0	1	14033	1074	38	1		1	SDK1	7	4272924	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08		4272924	154865739	90	34030											
TNRC18	84629	broad.mit.edu	37	chr7	5401259	5401259	+	Frame_Shift_Del	DEL	G	-	-																															gccgctcttccctctcttgcGggggggcgacagggcgctcg																										TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:5401259delG	uc003soi.3	-	14	4976	c.4627delC	c.(4627-4629)CGCfs	p.R1543fs		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1543							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CCTCTCTTGCGGGGGGGCGAC	0.692													---	---	---								-	5401259	-	-	5401259	7	5	181	1	0	1	0	1	0	0	0	0	16405	1116	39	0	4347	0	TNRC18	7	5401259	Frame_Shift_Del	DEL	G	TCGA-CV-5970-01A-11D-1683-08	1128335	5401259	153737404	91	34031											
C7orf31	136895	broad.mit.edu	37	chr7	25175685	25175685	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttatggtcttctagaattGatttatggaaacgcttttgt	9	19	8	5	1	2	2	0	1	2	1	2	3	2	3	0	2	1	1	0	2	5	9			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:25175685G>A	uc003sxn.1	-	10	2240	c.1679C>T	c.(1678-1680)TCA>TTA	p.S560L	C7orf31_uc003sxm.1_Missense_Mutation_p.S402L	NM_138811	NP_620166	Q8N865	CG031_HUMAN	hypothetical protein LOC136895	560											0						TTCTAGAATTGATTTATGGAA	0.403													16	83					0	0	0	0	A	25175685	A	A	25175685	3	1	181	1	0	0	0	0	1	0	0	0	2398	1294	45	2	97	2	C7orf31	7	25175685	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	19774426	25175685	133962978	92	34032											
STARD3NL	83930	broad.mit.edu	37	chr7	38259205	38259205	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcttcagagagggcagcacTtatacctggtggtctttctg	7	13	12	9	0	3	1	1	0	2	1	3	2	3	1	1	3	3	3	1	3	2	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:38259205T>G	uc003tfr.2	+	7	741	c.593T>G	c.(592-594)CTT>CGT	p.L198R	STARD3NL_uc003tfs.2_Missense_Mutation_p.L198R|STARD3NL_uc003tft.2_Missense_Mutation_p.L180R	NM_032016	NP_114405	O95772	MENTO_HUMAN	MLN64 N-terminal homolog	198	Cytoplasmic (Potential).|MENTAL.					integral to membrane|late endosome membrane				ovary(1)	1						AGGGCAGCACTTATACCTGGT	0.418													8	84					0	0	0	0	G	38259205	G	G	38259205	3	3	181	1	0	0	0	0	1	0	0	0	15324	1609	56	5	615	5	STARD3NL	7	38259205	Missense_Mutation	SNP	T	TCGA-CV-5970-01A-11D-1683-08	13083520	38259205	120879458	93	34033											
MYL7	58498	broad.mit.edu	37	chr7	44179945	44179945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcttctccccaaagagcGtgaggaagacggtgaagttg	11	8	14	8	2	1	5	0	3	1	2	2	6	1	6	2	2	2	2	2	2	3	2	rs142668114		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:44179945G>A	uc003tkg.2	-	4	287	c.275C>T	c.(274-276)ACG>ATG	p.T92M		NM_021223	NP_067046	Q01449	MLRA_HUMAN	myosin light chain 2a	92					actin filament-based movement|smooth muscle contraction	A band|myosin complex	ATPase activity, coupled|calcium ion binding|microfilament motor activity				0						CCCAAAGAGCGTGAGGAAGAC	0.527													10	71					0	0	0	0	A	44179945	A	A	44179945	3	1	181	1	0	0	0	0	1	0	0	0	10106	1145	40	1	268	1	MYL7	7	44179945	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	5920740	44179945	114958718	94	34034											
CCT6A	908	broad.mit.edu	37	chr7	56124052	56124052	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaagcaagatgaacctattGatctcttcatgattgagatc	15	12	7	7	0	2	5	1	4	1	2	4	6	2	5	1	0	2	1	1	0	5	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:56124052G>C	uc003trl.1	+	5	723	c.559G>C	c.(559-561)GAT>CAT	p.D187H	PSPH_uc003trj.2_Intron|CCT6A_uc003trm.1_Missense_Mutation_p.D142H|CCT6A_uc011kcu.1_Missense_Mutation_p.D156H	NM_001762	NP_001753	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A isoform	187					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			upper_aerodigestive_tract(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TGAACCTATTGATCTCTTCAT	0.343													10	68					0	0	0	0	C	56124052	C	C	56124052	3	2	181	1	0	0	0	0	1	0	0	0	2972	1290	45	2	577	2	CCT6A	7	56124052	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	11944107	56124052	103014611	95	34035											
SLC25A40	55972	broad.mit.edu	37	chr7	87476268	87476268	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataagataaatcctacctgaGaaaggtacatctctaagaac	18	9	6	8	0	1	3	0	1	1	3	3	4	2	3	2	1	3	1	2	1	8	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:87476268G>A	uc003uje.2	-	8	978	c.627C>T	c.(625-627)TTC>TTT	p.F209F		NM_018843	NP_061331	Q8TBP6	S2540_HUMAN	mitochondrial carrier family protein	209	Helical; Name=4; (Potential).|Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)	1	Esophageal squamous(14;0.00202)					TCCTACCTGAGAAAGGTACAT	0.378													11	56					0	0	0	0	A	87476268	A	A	87476268	2	1	181	1	0	0	0	0	0	0	0	1	14569	933	33	2		2	SLC25A40	7	87476268	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	31352216	87476268	71662395	96	34036											
PEX1	5189	broad.mit.edu	37	chr7	92136441	92136441	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcctaaggaattcactcctCtgtaaaaaatatacatagtt	15	12	5	9	1	2	0	1	0	1	0	3	1	3	1	2	1	1	2	2	1	8	7			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:92136441C>T	uc003uly.2	-	10	1767	c.1671_splice	c.e10-1	p.G557_splice	PEX1_uc011khr.1_Splice_Site_p.G349_splice|PEX1_uc010ley.2_Splice_Site_p.G557_splice|PEX1_uc011khs.1_Splice_Site_p.G235_splice|PEX1_uc011kht.1_Splice_Site	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1						microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			ATTCACTCCTCTGTAAAAAAT	0.403													4	21					0	0	0	0	T	92136441	T	T	92136441	5	4	181	1	0	0	0	0	0	0	1	0	11790	927	32	2	2241	2	PEX1	7	92136441	Splice_Site	SNP	C	TCGA-CV-5970-01A-11D-1683-08	4660173	92136441	67002222	97	34037											
COG5	10466	broad.mit.edu	37	chr7	107053006	107053006	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttccacttcaagtcgggCtcttgcaataaaaagtagat	13	13	7	8	1	2	1	1	0	1	1	4	1	3	1	1	1	1	3	1	1	6	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:107053006C>T	uc003ved.2	-	7	1228	c.703G>A	c.(703-705)GCC>ACC	p.A235T	COG5_uc003vec.2_Missense_Mutation_p.A235T|COG5_uc003vee.2_Missense_Mutation_p.A235T	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	235					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						TCAAGTCGGGCTCTTGCAATA	0.328													18	51					0	0	0	0	T	107053006	T	T	107053006	3	4	181	1	0	0	0	0	1	0	0	0	3676	797	28	4	1947	4	COG5	7	107053006	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	14916565	107053006	52085657	98	34038											
WNT16	51384	broad.mit.edu	37	chr7	120979112	120979112	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggaaaatgcgcaggagaGaaaaagatcagaggaaaata	22	3	13	3	1	1	4	1	0	0	4	1	8	1	7	0	3	1	1	0	3	7	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:120979112G>C	uc003vjw.2	+	4	1068	c.811G>C	c.(811-813)GAA>CAA	p.E271Q	WNT16_uc003vjv.2_Missense_Mutation_p.E261Q|WNT16_uc010lkl.2_Missense_Mutation_p.E55Q	NM_057168	NP_476509	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family,	271					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			lung(2)|ovary(2)|large_intestine(1)	5	all_neural(327;0.117)					GCGCAGGAGAGAAAAAGATCA	0.368													6	24					0	0	0	0	C	120979112	C	C	120979112	3	2	181	1	0	0	0	0	1	0	0	0	17453	943	33	2	894	2	WNT16	7	120979112	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	13926106	120979112	38159551	99	34039											
PRKAG2	51422	broad.mit.edu	37	chr7	151261269	151261269	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgaagggcctgggtcacCgtgatatctaggttattgta	8	13	13	7	1	2	2	1	2	1	0	2	2	2	2	2	3	1	3	2	3	5	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr7:151261269C>T	uc003wkk.2	-	14	2090	c.1479G>A	c.(1477-1479)ACG>ACA	p.T493T	PRKAG2_uc003wki.2_Silent_p.T252T|PRKAG2_uc011kvl.1_Silent_p.T368T|PRKAG2_uc003wkj.2_Silent_p.T449T|PRKAG2_uc003wkl.2_Silent_p.T41T	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	493					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CCTGGGTCACCGTGATATCTA	0.398													5	91					0	0	0	0	T	151261269	T	T	151261269	2	4	181	1	0	0	0	0	0	0	0	1	12563	639	23	1		1	PRKAG2	7	151261269	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	30282157	151261269	7877394	100	34040											
SFTPC	6440	broad.mit.edu	37	chr8	22019379	22019379	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggtcctgatggagagccCgccggtgagtgtggttgcgt	6	9	18	8	3	0	4	0	2	0	2	1	5	1	4	3	4	2	1	3	4	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr8:22019379C>T	uc003xax.3	+	1	196	c.38C>T	c.(37-39)CCG>CTG	p.P13L	SFTPC_uc003xaw.3_Missense_Mutation_p.P62L|SFTPC_uc011kza.1_Missense_Mutation_p.P13L|SFTPC_uc003xaz.2_Missense_Mutation_p.P13L|SFTPC_uc003xay.3_Missense_Mutation_p.P13L	NM_003018	NP_003009	P11686	PSPC_HUMAN	surfactant protein C precursor	13					respiratory gaseous exchange	extracellular space					0				Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		ATGGAGAGCCCGCCGgtgagt	0.433													13	53					0	0	0	0	T	22019379	T	T	22019379	3	4	181	1	0	0	0	0	1	0	0	0	14257	652	23	1	40	1	SFTPC	8	22019379	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08		22019379	124344643	101	34041											
SLC39A14	23516	broad.mit.edu	37	chr8	22266000	22266000	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggaggaggggcggccaagcGctgttgaaggtgagccaggc	8	4	20	9	3	0	2	0	2	0	0	0	4	0	4	2	7	2	2	2	7	2	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr8:22266000G>A	uc003xbq.3	+	3	623	c.448G>A	c.(448-450)GCT>ACT	p.A150T	SLC39A14_uc011kzg.1_Missense_Mutation_p.A150T|SLC39A14_uc003xbp.3_Missense_Mutation_p.A150T|SLC39A14_uc011kzh.1_Missense_Mutation_p.A150T	NM_001128431	NP_001121903	Q15043	S39AE_HUMAN	solute carrier family 39 (zinc transporter),	150	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity				0				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)		GCGGCCAAGCGCTGTTGAAGG	0.642													4	19					0	0	0	0	A	22266000	A	A	22266000	3	1	181	1	0	0	0	0	1	0	0	0	14681	1087	38	1	454	1	SLC39A14	8	22266000	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	246621	22266000	124098022	102	34042											
PRKDC	5591	broad.mit.edu	37	chr8	48798673	48798673	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggacgccgtggacagcacCgctgggttcaggagaagact	11	5	15	10	3	1	2	1	0	0	2	1	5	1	4	2	4	1	3	2	4	2	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr8:48798673C>T	uc003xqi.2	-	37	4665	c.4608G>A	c.(4606-4608)GCG>GCA	p.A1536A	PRKDC_uc003xqj.2_Silent_p.A1536A|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1536	Interaction with C1D.|Leucine-zipper.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGGACAGCACCGCTGGGTTCA	0.527								NHEJ					17	23					0	0	0	0	T	48798673	T	T	48798673	2	4	181	1	0	0	0	0	0	0	0	1	12583	639	23	1		1	PRKDC	8	48798673	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	26532673	48798673	97565349	103	34043											
XKR4	114786	broad.mit.edu	37	chr8	56436657	56436657	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataggtacccagcatgggaGagacatgttttggaccgaag	13	8	13	7	1	0	1	0	0	0	1	0	5	0	3	2	3	2	3	2	3	4	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr8:56436657G>C	uc003xsf.2	+	3	1856	c.1824G>C	c.(1822-1824)GAG>GAC	p.E608D		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	608						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			CAGCATGGGAGAGACATGTTT	0.488													7	28					0	0	0	0	C	56436657	C	C	56436657	3	2	181	1	0	0	0	0	1	0	0	0	17501	933	33	2	1834	2	XKR4	8	56436657	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	7637984	56436657	89927365	104	34044											
CHD7	55636	broad.mit.edu	37	chr8	61765187	61765187	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcttgacaaaaaatctgatGagagtttggagaaatacttc	15	11	10	5	0	1	4	0	3	1	2	2	6	1	4	0	2	1	2	0	2	5	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr8:61765187G>A	uc003xue.2	+	30	6502	c.6025G>A	c.(6025-6027)GAG>AAG	p.E2009K		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2009					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AAAATCTGATGAGAGTTTGGA	0.438													9	22					0	0	0	0	A	61765187	A	A	61765187	3	1	181	1	0	0	0	0	1	0	0	0	3345	1291	45	2	6139	2	CHD7	8	61765187	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	5328530	61765187	84598835	105	34045											
KIFC2	90990	broad.mit.edu	37	chr8	145698053	145698053	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccctggtcacgctgacgctgCgcgcggcgtctccaccgcgc	3	6	13	19	8	2	1	1	1	1	0	3	1	2	1	3	2	1	2	3	2	0	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr8:145698053C>T	uc003zcz.2	+	16	1890	c.1825C>T	c.(1825-1827)CGC>TGC	p.R609C	KIFC2_uc003zda.2_5'UTR	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	609	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GCTGACGCTGCGCGCGGCGTC	0.721													4	27					0	0	0	0	T	145698053	T	T	145698053	3	4	181	1	0	0	0	0	1	0	0	0	8352	768	27	1	1887	1	KIFC2	8	145698053	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	83932866	145698053	665969	106	34046											
PHF2	5253	broad.mit.edu	37	chr9	96435940	96435940	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggccaacctgcaggcctccGactcctgcctgcagaccacg	7	6	10	18	2	0	1	0	0	0	1	2	2	2	1	7	2	4	2	7	2	1	0	rs145764244	byFrequency	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr9:96435940G>A	uc004aub.2	+	18	2569	c.2422G>A	c.(2422-2424)GAC>AAC	p.D808N	PHF2_uc011lug.1_Missense_Mutation_p.D691N|PHF2_uc004auc.2_Missense_Mutation_p.D228N	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	808					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		GCAGGCCTCCGACTCCTGCCT	0.667													8	55					0	0	0	0	A	96435940	A	A	96435940	3	1	181	1	0	0	0	0	1	0	0	0	11885	1058	37	1	2492	1	PHF2	9	96435940	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08		96435940	44777491	107	34047											
GSN	2934	broad.mit.edu	37	chr9	124073041	124073041	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actcttccaggtcaaagggcGgcgtgtggtccgtgccaccg	6	8	14	13	4	2	0	1	0	1	0	4	0	4	0	4	4	1	0	4	4	1	1	rs144099356	by1000genomes	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr9:124073041G>A	uc004blf.1	+	4	645	c.584G>A	c.(583-585)CGG>CAG	p.R195Q	GSN_uc004bld.1_Missense_Mutation_p.R144Q|GSN_uc010mvq.1_Missense_Mutation_p.R155Q|GSN_uc010mvr.1_Missense_Mutation_p.R155Q|GSN_uc010mvu.1_Missense_Mutation_p.R144Q|GSN_uc010mvt.1_Missense_Mutation_p.R144Q|GSN_uc010mvs.1_Missense_Mutation_p.R144Q|GSN_uc004ble.1_Missense_Mutation_p.R144Q|GSN_uc010mvv.1_Missense_Mutation_p.R144Q|GSN_uc011lyh.1_Missense_Mutation_p.R161Q|GSN_uc011lyi.1_Missense_Mutation_p.R144Q|GSN_uc011lyj.1_Missense_Mutation_p.R168Q|GSN_uc004blg.1_5'Flank	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	195	Polyphosphoinositide binding (By similarity).				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						GTCAAAGGGCGGCGTGTGGTC	0.587													8	47					0	0	0	0	A	124073041	A	A	124073041	3	1	181	1	0	0	0	0	1	0	0	0	6864	1116	39	1	626	1	GSN	9	124073041	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	27637101	124073041	17140390	108	34048											
FCN2	2220	broad.mit.edu	37	chr9	137779204	137779204	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatggcatcaactggaagtcGgggaaaggatacaattatag	16	8	12	5	1	1	0	1	0	0	0	2	3	1	3	0	5	2	1	0	5	8	3	rs150154280	byFrequency	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr9:137779204G>A	uc004cfg.1	+	8	895	c.885G>A	c.(883-885)TCG>TCA	p.S295S	FCN2_uc004cfh.1_Silent_p.S257S	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	295	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		ACTGGAAGTCGGGGAAAGGAT	0.537													45	16					0	0	0	0	A	137779204	A	A	137779204	2	1	181	1	0	0	0	0	0	0	0	1	5824	1103	39	1		1	FCN2	9	137779204	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	13706163	137779204	3434227	109	34049											
KIAA0649	9858	broad.mit.edu	37	chr9	138376726	138376726	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccgttggtgctagattcaGacagtgatgattccgtggac	8	11	13	9	2	1	4	1	2	0	2	2	5	2	5	2	2	1	2	2	2	1	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr9:138376726G>C	uc004cfr.1	+	4	919	c.370G>C	c.(370-372)GAC>CAC	p.D124H		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	124						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		GCTAGATTCAGACAGTGATGA	0.612													71	49					0	0	0	0	C	138376726	C	C	138376726	3	2	181	1	0	0	0	0	1	0	0	0	8226	942	33	2	372	2	KIAA0649	9	138376726	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	597522	138376726	2836705	110	34050											
PITRM1	10531	broad.mit.edu	37	chr10	3189404	3189404	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcttcctcaggatgggtttGatatctgtcatttctgcaat	8	16	9	8	0	4	1	2	1	2	0	5	2	5	2	1	2	2	3	1	2	2	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr10:3189404G>C	uc010qah.1	-	17	2012	c.1980C>G	c.(1978-1980)ATC>ATG	p.I660M	PITRM1_uc001igr.1_Missense_Mutation_p.I758M|PITRM1_uc001igs.1_5'Flank|PITRM1_uc001igt.1_Missense_Mutation_p.I758M|PITRM1_uc009xhv.1_Missense_Mutation_p.I324M|PITRM1_uc001igu.1_Missense_Mutation_p.I684M|PITRM1_uc010qai.1_Missense_Mutation_p.I729M|uc001igv.1_RNA			E7ES23	E7ES23_HUMAN	SubName: Full=cDNA FLJ54065, moderately similar to Mus musculus pitrilysin metallepetidase 1 (Pitrm1), mRNA;	660					proteolysis		metalloendopeptidase activity|zinc ion binding			pancreas(1)	1						GGATGGGTTTGATATCTGTCA	0.438													8	49					0	0	0	0	C	3189404	C	C	3189404	3	2	181	1	0	0	0	0	1	0	0	0	12008	1280	45	2	871	2	PITRM1	10	3189404	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08		3189404	132345343	111	34051											
SFMBT2	57713	broad.mit.edu	37	chr10	7409703	7409703	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacaccagaagtcggccctgCggtcctccccgtaaccgcag	8	5	10	18	4	0	1	0	0	0	1	3	1	2	1	6	2	2	2	6	2	2	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr10:7409703C>T	uc009xio.1	-	4	435	c.344G>A	c.(343-345)CGC>CAC	p.R115H	SFMBT2_uc001ijn.1_Missense_Mutation_p.R115H|SFMBT2_uc010qay.1_Missense_Mutation_p.R115H|SFMBT2_uc001ijo.1_Missense_Mutation_p.R115H	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	115	MBT 1.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						GTCGGCCCTGCGGTCCTCCCC	0.612													7	35					0	0	0	0	T	7409703	T	T	7409703	3	4	181	1	0	0	0	0	1	0	0	0	14223	768	27	1	2412	1	SFMBT2	10	7409703	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	4220299	7409703	128125044	112	34052											
GDF2	2658	broad.mit.edu	37	chr10	48414496	48414496	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttctggaaggggaagtcCtctgtggcagttatggagat	8	12	15	6	0	2	1	0	0	2	1	3	4	3	3	1	5	1	3	1	5	3	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr10:48414496C>T	uc001jfa.1	-	2	535	c.372G>A	c.(370-372)GAG>GAA	p.E124E		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	124					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						AGGGGAAGTCCTCTGTGGCAG	0.507													3	21					0	0	0	0	T	48414496	T	T	48414496	2	4	181	1	0	0	0	0	0	0	0	1	6351	680	24	4		4	GDF2	10	48414496	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	41004793	48414496	87120251	113	34053											
JMJD1C	221037	broad.mit.edu	37	chr10	64979732	64979732	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagaactgggtttaggctGtctatgtcgtcctagaatta	9	14	11	7	1	1	2	0	1	1	2	3	3	2	2	1	2	1	2	1	2	6	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr10:64979732G>C	uc001jmn.2	-	4	759	c.459C>G	c.(457-459)GAC>GAG	p.D153E	JMJD1C_uc001jml.2_Intron|JMJD1C_uc001jmm.2_5'UTR|JMJD1C_uc010qiq.1_5'UTR|JMJD1C_uc009xpi.2_5'UTR|JMJD1C_uc009xpj.1_Intron|JMJD1C_uc001jmp.1_Intron	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	153					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GGTTTAGGCTGTCTATGTCGT	0.423													17	70					0	0	0	0	C	64979732	C	C	64979732	3	2	181	1	0	0	0	0	1	0	0	0	7989	1368	48	4	7255	4	JMJD1C	10	64979732	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	16565236	64979732	70555015	114	34054											
LRRTM3	347731	broad.mit.edu	37	chr10	68857399	68857399	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catacgaccagcccacaataAgttactgtggggtgcatcat	12	9	9	11	1	1	0	1	0	0	0	1	1	1	0	2	2	4	2	2	2	4	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr10:68857399A>C	uc001jmz.1	+	3	2141	c.1591A>C	c.(1591-1593)AGT>CGT	p.S531R	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	531	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GCCCACAATAAGTTACTGTGG	0.418													9	87					0	0	0	0	C	68857399	C	C	68857399	3	2	181	1	0	0	0	0	1	0	0	0	9091	72	3	5	1601	5	LRRTM3	10	68857399	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08	3877667	68857399	66677348	115	34055											
ENTPD7	57089	broad.mit.edu	37	chr10	101439180	101439180	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctggacatcaaacagatGagagaccgcaacagccaacc	15	5	9	12	1	1	3	1	1	0	2	1	5	1	4	3	1	5	2	3	1	3	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr10:101439180G>A	uc001kqa.3	+	4	532	c.354G>A	c.(352-354)ATG>ATA	p.M118I	ENTPD7_uc009xwl.2_Missense_Mutation_p.M120I	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	118	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		TCAAACAGATGAGAGACCGCA	0.428													4	28					0	0	0	0	A	101439180	A	A	101439180	3	1	181	1	0	0	0	0	1	0	0	0	5168	1290	45	2	364	2	ENTPD7	10	101439180	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	32581781	101439180	34095567	116	34056											
ITPRIP	85450	broad.mit.edu	37	chr10	106075039	106075039	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccccgagcttggtcttgccGcagatgcagctcaatgtgtc	6	11	11	13	2	2	1	1	0	1	1	4	2	3	1	3	1	4	4	3	1	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr10:106075039G>A	uc001kye.2	-	2	844	c.771C>T	c.(769-771)TGC>TGT	p.C257C	ITPRIP_uc001kyf.2_Silent_p.C257C|ITPRIP_uc001kyg.2_Silent_p.C257C	NM_033397	NP_203755	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-triphosphate receptor interacting	257						plasma membrane					0						TGGTCTTGCCGCAGATGCAGC	0.647													24	51					0	0	0	0	A	106075039	A	A	106075039	2	1	181	1	0	0	0	0	0	0	0	1	7962	1079	38	1		1	ITPRIP	10	106075039	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	4635859	106075039	29459708	117	34057											
COPB1	1315	broad.mit.edu	37	chr11	14490304	14490304	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgccagtaaactcagctGaaactgatcttccttgcagt	10	12	8	11	0	2	2	1	2	1	0	3	2	3	2	2	0	6	4	2	0	3	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:14490304G>A	uc001mli.2	-	16	2375	c.2068C>T	c.(2068-2070)CAG>TAG	p.Q690*	COPB1_uc001mlg.2_Nonsense_Mutation_p.Q690*|COPB1_uc001mlh.2_Nonsense_Mutation_p.Q690*	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	690					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						AAACTCAGCTGAAACTGATCT	0.423													18	149					0	0	0	0	A	14490304	A	A	14490304	4	1	181	1	0	0	0	0	0	1	0	0	3743	1299	45	2	821	2	COPB1	11	14490304	Nonsense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08		14490304	120516212	118	34058											
ELP4	26610	broad.mit.edu	37	chr11	31805046	31805046	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggctgtggcatgatggccGgaggcaagaagcacctggac	10	5	16	10	1	0	2	0	1	0	1	0	4	0	4	2	6	1	4	2	6	2	0	rs3026403		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:31805046G>A	uc001mtb.2	+	10	1284	c.1249G>A	c.(1249-1251)GGA>AGA	p.G417R	ELP4_uc001mtc.2_3'UTR|ELP4_uc010rdz.1_Missense_Mutation_p.R464Q	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	417					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					CATGATGGCCGGAGGCAAGAA	0.498													3	74					0	0	0	0	A	31805046	A	A	31805046	3	1	181	1	0	0	0	0	1	0	0	0	5106	1117	39	1	1287	1	ELP4	11	31805046	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	17314742	31805046	103201470	119	34059											
OR4A15	81328	broad.mit.edu	37	chr11	55135812	55135812	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtaatggcctatgatcgataCatggccatctgtaagcctct	10	12	9	10	1	2	1	0	1	2	0	3	2	2	1	3	2	2	2	3	2	4	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:55135812C>A	uc010rif.1	+	1	453	c.453C>A	c.(451-453)TAC>TAA	p.Y151*		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	151	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATGATCGATACATGGCCATCT	0.438													35	154					4.3181e-19	4.74832e-19	1	0	A	55135812	A	A	55135812	4	1	181	1	0	0	0	0	0	1	0	0	11094	489	17	4	455	4	OR4A15	11	55135812	Nonsense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	23330766	55135812	79870704	120	34060											
OR5AS1	219447	broad.mit.edu	37	chr11	55798369	55798369	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtacaacatcactggtcCatgtgtgcctcacattcagg	11	10	9	11	0	3	0	3	0	0	0	4	1	4	0	2	2	3	1	2	2	3	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:55798369C>T	uc010riw.1	+	1	475	c.475C>T	c.(475-477)CAT>TAT	p.H159Y		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					ATCACTGGTCCATGTGTGCCT	0.438													66	107					0	0	0	0	T	55798369	T	T	55798369	3	4	181	1	0	0	0	0	1	0	0	0	11200	594	21	4	477	4	OR5AS1	11	55798369	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	662557	55798369	79208147	121	34061											
C11orf10	746	broad.mit.edu	37	chr11	61558011	61558011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaatggccaaaagcaccaCggtcagatgggggaagacag	14	3	14	10	1	1	2	1	0	0	2	1	3	1	3	3	4	1	1	3	4	4	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:61558011C>T	uc001nsf.2	-	2	122	c.67G>A	c.(67-69)GTG>ATG	p.V23M	FEN1_uc001nsg.2_5'Flank	NM_014206	NP_055021	P61165	CK010_HUMAN	hypothetical protein LOC746	23	Helical; (Potential).					integral to membrane				breast(1)	1						AAAAGCACCACGGTCAGATGG	0.527													8	13					0	0	0	0	T	61558011	T	T	61558011	3	4	181	1	0	0	0	0	1	0	0	0	1636	536	19	1	180	1	C11orf10	11	61558011	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	5759642	61558011	73448505	122	34062											
CCDC88B	283234	broad.mit.edu	37	chr11	64120247	64120247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggcccagcgggccagcGtggaggcacaggaggtggcc	7	3	19	12	2	0	0	0	0	0	0	0	2	0	2	3	7	3	2	3	7	0	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:64120247G>A	uc001nzy.2	+	20	3432	c.3388G>A	c.(3388-3390)GTG>ATG	p.V1130M	CCDC88B_uc009ypo.1_Missense_Mutation_p.V1127M|CCDC88B_uc001oaa.2_Missense_Mutation_p.V282M|CCDC88B_uc001oab.1_5'Flank|CCDC88B_uc001oac.2_5'Flank	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	1130	Potential.				microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						GCGGGCCAGCGTGGAGGCACA	0.657													4	63					0	0	0	0	A	64120247	A	A	64120247	3	1	181	1	0	0	0	0	1	0	0	0	2877	1145	40	1	3466	1	CCDC88B	11	64120247	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	2562236	64120247	70886269	123	34063											
ATG2A	23130	broad.mit.edu	37	chr11	64678743	64678743	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagggggttgggggccatCttgcctgaggggacagaggc	7	6	21	7	0	1	2	0	1	1	1	1	4	1	4	2	8	1	1	2	8	0	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:64678743C>T	uc001obx.2	-	10	1348	c.1233G>A	c.(1231-1233)AAG>AAA	p.K411K		NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	411							protein binding			ovary(1)|central_nervous_system(1)	2						TGGGGGCCATCTTGCCTGAGG	0.632													28	46					0	0	0	0	T	64678743	T	T	64678743	2	4	181	1	0	0	0	0	0	0	0	1	1095	912	32	2		2	ATG2A	11	64678743	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	558496	64678743	70327773	124	34064											
NAALADL1	10004	broad.mit.edu	37	chr11	64825688	64825688	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caccaggtcctcatcccgagGgctggaggccaggtgtggct	6	7	15	13	1	1	0	1	0	0	0	3	2	3	1	4	6	0	2	4	6	0	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:64825688G>A	uc001ocn.2	-	2	236	c.220C>T	c.(220-222)CCT>TCT	p.P74S	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	74	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						TCATCCCGAGGGCTGGAGGCC	0.677													5	40					0	0	0	0	A	64825688	A	A	64825688	3	1	181	1	0	0	0	0	1	0	0	0	10182	1232	43	4	2070	4	NAALADL1	11	64825688	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	146945	64825688	70180828	125	34065											
LRP5	4041	broad.mit.edu	37	chr11	68131338	68131338	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacaagcgcactggggggaaGaggaaggagatcctgagtgc	13	4	17	7	1	0	3	0	1	0	2	1	6	1	5	1	5	3	1	1	5	4	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:68131338G>A	uc001ont.2	+	4	885	c.810G>A	c.(808-810)AAG>AAA	p.K270K	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	270	LDL-receptor class B 5.|Beta-propeller 1.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CTGGGGGGAAGAGGAAGGAGA	0.587													7	63					0	0	0	0	A	68131338	A	A	68131338	2	1	181	1	0	0	0	0	0	0	0	1	9010	933	33	2		2	LRP5	11	68131338	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	3305650	68131338	66875178	126	34066											
CTTN	2017	broad.mit.edu	37	chr11	70281261	70281261	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccaactatgtggagctgcGgcagtagggcccccagcccc	8	5	13	15	1	0	0	0	0	0	0	0	1	0	1	5	3	5	3	5	3	3	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:70281261G>A	uc001opv.3	+	18	1852	c.1646G>A	c.(1645-1647)CGG>CAG	p.R549Q	CTTN_uc001opu.2_Intron|CTTN_uc001opw.3_Missense_Mutation_p.R512Q|CTTN_uc010rqm.1_Intron|CTTN_uc001opx.2_Missense_Mutation_p.R233Q	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	549	SH3.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GTGGAGCTGCGGCAGTAGGGC	0.587													11	36					0	0	0	0	A	70281261	A	A	70281261	3	1	181	1	0	0	0	0	1	0	0	0	4061	1116	39	1	1708	1	CTTN	11	70281261	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	2149923	70281261	64725255	127	34067											
MAP6	4135	broad.mit.edu	37	chr11	75299192	75299192	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgtggctacaggaccttGagtcttacttgaatcactga	9	13	9	10	0	3	3	1	3	2	0	3	4	3	4	1	2	2	1	1	2	3	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:75299192G>A	uc001owu.2	-	4	1419	c.1354C>T	c.(1354-1356)CAA>TAA	p.Q452*		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	452						Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					ACAGGACCTTGAGTCTTACTT	0.537													16	53					0	0	0	0	A	75299192	A	A	75299192	4	1	181	1	0	0	0	0	0	1	0	0	9317	1299	45	2	1091	2	MAP6	11	75299192	Nonsense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	5017931	75299192	59707324	128	34068											
INTS4	92105	broad.mit.edu	37	chr11	77590009	77590009	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tttgccttagcgccgtgcagGtttgggcattatataaactt	8	15	10	8	2	0	0	0	0	0	0	0	0	0	0	2	2	4	3	2	2	5	7			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:77590009G>C	uc001oys.2	-	23	2906	c.2878C>G	c.(2878-2880)CCT>GCT	p.P960A	C11orf67_uc001oyp.2_Intron|C11orf67_uc001oyr.1_Intron|INTS4_uc001oyt.2_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	960					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			CGCCGTGCAGGTTTGGGCATT	0.527													8	76					0	0	0	0	C	77590009	C	C	77590009	3	2	181	1	0	0	0	0	1	0	0	0	7819	1261	44	4	17	4	INTS4	11	77590009	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	2290817	77590009	57416507	129	34069											
CCDC89	220388	broad.mit.edu	37	chr11	85396236	85396236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactgcctcttgctcaaacCgctccagcgcatgcttcctg	6	10	7	18	2	2	0	1	0	1	0	4	0	4	0	5	0	5	4	5	0	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr11:85396236C>T	uc001pau.1	-	1	1085	c.938G>A	c.(937-939)CGG>CAG	p.R313Q		NM_152723	NP_689936	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	313	Potential.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TTGCTCAAACCGCTCCAGCGC	0.512													14	51					0	0	0	0	T	85396236	T	T	85396236	3	4	181	1	0	0	0	0	1	0	0	0	2879	652	23	1	190	1	CCDC89	11	85396236	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	7806227	85396236	49610280	130	34070											
EFCAB4B	84766	broad.mit.edu	37	chr12	3757747	3757747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggagcccggccttctcaCgctgtagactctccgtcaca	7	9	10	15	3	3	2	2	1	2	1	5	3	3	3	3	2	1	2	3	2	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:3757747C>T	uc001qmj.2	-	11	1651	c.1079G>A	c.(1078-1080)CGT>CAT	p.R360H	EFCAB4B_uc010sen.1_Missense_Mutation_p.R360H|EFCAB4B_uc010seo.1_Missense_Mutation_p.R360H|EFCAB4B_uc001qmi.1_RNA	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	360	Potential.				activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			GGCCTTCTCACGCTGTAGACT	0.622													5	36					0	0	0	0	T	3757747	T	T	3757747	3	4	181	1	0	0	0	0	1	0	0	0	4959	536	19	1	1348	1	EFCAB4B	12	3757747	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08		3757747	130094148	131	34071											
VWF	7450	broad.mit.edu	37	chr12	6135131	6135131	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcccaaagtccacagggtCttcctccacttggaggttgc	7	11	10	13	0	1	0	0	0	1	0	5	1	5	1	4	3	1	2	4	3	1	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:6135131C>T	uc001qnn.1	-	23	3299	c.3049G>A	c.(3049-3051)GAC>AAC	p.D1017N	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1017	VWFD 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	TCCACAGGGTCTTCCTCCACT	0.527													13	63					0	0	0	0	T	6135131	T	T	6135131	3	4	181	1	0	0	0	0	1	0	0	0	17314	913	32	2	5512	2	VWF	12	6135131	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	2377384	6135131	127716764	132	34072											
CHD4	1108	broad.mit.edu	37	chr12	6688057	6688057	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagatctattgctgacttttCctccaccttctctacatcag	8	15	4	14	0	3	2	1	1	2	1	6	2	5	2	3	0	2	1	3	0	2	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:6688057C>T	uc001qpo.2	-	34	5100	c.4936G>A	c.(4936-4938)GAA>AAA	p.E1646K	CHD4_uc001qpn.2_Missense_Mutation_p.E1639K|CHD4_uc001qpp.2_Missense_Mutation_p.E1671K|uc001qpq.1_Intron	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1646	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCTGACTTTTCCTCCACCTTC	0.413													6	24					0	0	0	0	T	6688057	T	T	6688057	3	4	181	1	0	0	0	0	1	0	0	0	3342	864	30	2	830	2	CHD4	12	6688057	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	552926	6688057	127163838	133	34073											
CHD4	1108	broad.mit.edu	37	chr12	6690555	6690555	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctatttttatcccatcttCtgcagaacaataaaagacaa	15	13	3	10	0	3	2	0	0	3	2	4	2	4	2	1	0	2	1	1	0	7	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:6690555C>G	uc001qpo.2	-	32	4846	c.4682_splice	c.e32-1	p.E1561_splice	CHD4_uc001qpn.2_Splice_Site_p.E1554_splice|CHD4_uc001qpp.2_Splice_Site_p.E1586_splice|uc001qpq.1_Intron	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ATCCCATCTTCTGCAGAACAA	0.403													5	67					0	0	0	0	G	6690555	G	G	6690555	5	3	181	1	0	0	0	0	0	0	1	0	3342	927	32	2	1093	2	CHD4	12	6690555	Splice_Site	SNP	C	TCGA-CV-5970-01A-11D-1683-08	2498	6690555	127161340	134	34074											
TPI1	7167	broad.mit.edu	37	chr12	6979473	6979473	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagctggccagccagcctGatgtggatggcttccttgtg	6	10	15	10	0	0	1	0	1	0	0	1	3	1	3	4	4	3	2	4	4	0	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:6979473G>A	uc001qrk.2	+	7	714	c.676G>A	c.(676-678)GAT>AAT	p.D226N	TPI1_uc010sfo.1_Missense_Mutation_p.D144N	NM_000365	NP_000356	P60174	TPIS_HUMAN	triosephosphate isomerase 1 isoform 1	226					fatty acid biosynthetic process|gluconeogenesis|glycolysis|pentose-phosphate shunt	cytosol	triose-phosphate isomerase activity				0						CAGCCAGCCTGATGTGGATGG	0.572											OREG0021638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	24					0	0	0	0	A	6979473	A	A	6979473	3	1	181	1	0	0	0	0	1	0	0	0	16470	1290	45	2	813	2	TPI1	12	6979473	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	288918	6979473	126872422	135	34075											
PZP	5858	broad.mit.edu	37	chr12	9349219	9349219	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaagcttcatttcaaagccCgtatttgtaatctggagcat	11	14	7	9	1	3	0	2	0	1	0	3	1	3	1	1	1	3	4	1	1	4	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:9349219C>T	uc001qvl.2	-	9	959	c.930G>A	c.(928-930)ACG>ACA	p.T310T	PZP_uc009zgl.2_Silent_p.T179T	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TTTCAAAGCCCGTATTTGTAA	0.393													13	70					0	0	0	0	T	9349219	T	T	9349219	2	4	181	1	0	0	0	0	0	0	0	1	12934	639	23	1		1	PZP	12	9349219	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	2369746	9349219	124502676	136	34076											
BCL2L14	79370	broad.mit.edu	37	chr12	12232347	12232347	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacaccagacatcatgtcttCaagagcacccctgctctctt	10	11	5	15	0	4	2	2	0	2	2	5	2	4	2	3	0	3	2	3	0	2	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:12232347C>G	uc001rac.2	+	2	309	c.108C>G	c.(106-108)TTC>TTG	p.F36L	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_RNA|BCL2L14_uc001rad.2_Missense_Mutation_p.F36L|BCL2L14_uc001rae.2_Missense_Mutation_p.F36L	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	36					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		ATCATGTCTTCAAGAGCACCC	0.493													13	38					0	0	0	0	G	12232347	G	G	12232347	3	3	181	1	0	0	0	0	1	0	0	0	1374	825	29	2	110	2	BCL2L14	12	12232347	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	2883128	12232347	121619548	137	34077											
PPFIBP1	8496	broad.mit.edu	37	chr12	27841992	27841992	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaacaatggctcagttattGaacatcccacccaataagac	16	8	6	11	0	1	2	1	1	0	1	2	3	2	2	2	1	2	2	2	1	6	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:27841992G>A	uc001ric.1	+	26	2936	c.2559G>A	c.(2557-2559)TTG>TTA	p.L853L	PPFIBP1_uc010sjr.1_Silent_p.L684L|PPFIBP1_uc001rib.1_Silent_p.L847L|PPFIBP1_uc001ria.2_Silent_p.L822L|PPFIBP1_uc001rid.1_Silent_p.L700L|PPFIBP1_uc001rif.1_Silent_p.L360L	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	853	SAM 3.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					CTCAGTTATTGAACATCCCAC	0.408													10	68					0	0	0	0	A	27841992	A	A	27841992	2	1	181	1	0	0	0	0	0	0	0	1	12368	1281	45	2		2	PPFIBP1	12	27841992	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	15609645	27841992	106009903	138	34078											
PRICKLE1	144165	broad.mit.edu	37	chr12	42853994	42854008	+	In_Frame_Del	DEL	TGTACAGCCGCAGTC	-	-																															tttctcatagttatcgggggTgtacagccgcagtctgtcct																										TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:42853994_42854008delTGTACAGCCGCAGTC	uc010skv.1	-	8	2386_2400	c.2099_2113delGACTGCGGCTGTACA	c.(2098-2115)AGACTGCGGCTGTACACC>ACC	p.RLRLY700del	PRICKLE1_uc001rnl.2_In_Frame_Del_p.RLRLY700del|PRICKLE1_uc010skw.1_In_Frame_Del_p.RLRLY700del|PRICKLE1_uc001rnm.2_In_Frame_Del_p.RLRLY700del|PRICKLE1_uc001rnk.1_5'Flank	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	700_704					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		TTATCGGGGGTGTACAGCCGCAGTCTGTCCTTGGG	0.502													---	---	---								-	42854008	-	-	42853994	7	5	181	1	0	1	0	1	0	0	0	0	12548	1696	59	0	386	0	PRICKLE1	12	42853994	In_Frame_Del	DEL	TGTACAGCCGCAGTC	TCGA-CV-5970-01A-11D-1683-08	15012002	42853994	90997901	139	34079											
ANO6	196527	broad.mit.edu	37	chr12	45810577	45810577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tattggaaataagagtggacGcatggaaactgaccacccag	15	7	11	8	1	0	2	0	1	0	1	0	5	0	5	2	3	1	1	2	3	4	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:45810577G>A	uc001roo.2	+	17	2442	c.2107G>A	c.(2107-2109)GCA>ACA	p.A703T	ANO6_uc010sld.1_Missense_Mutation_p.A703T|ANO6_uc010sle.1_Missense_Mutation_p.A703T|ANO6_uc010slf.1_Missense_Mutation_p.A724T|ANO6_uc010slg.1_Missense_Mutation_p.A685T	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	703	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						AAGAGTGGACGCATGGAAACT	0.483													9	28					0	0	0	0	A	45810577	A	A	45810577	3	1	181	1	0	0	0	0	1	0	0	0	701	1087	38	1	2193	1	ANO6	12	45810577	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	2956583	45810577	88041318	140	34080											
COL2A1	1280	broad.mit.edu	37	chr12	48367873	48367873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggcagccccactcaccGtgcagccatccttcagggca	7	7	9	18	1	3	0	2	0	1	0	4	0	4	0	5	2	3	3	5	2	0	1	rs121912886		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:48367873G>A	uc001rqu.2	-	53	4497	c.4316C>T	c.(4315-4317)ACG>ATG	p.T1439M	COL2A1_uc001rqt.2_Missense_Mutation_p.T220M|COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.T1370M	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	1439	Fibrillar collagen NC1.		T -> M (in SEDC).		axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CCCACTCACCGTGCAGCCATC	0.617													7	52					0	0	0	0	A	48367873	A	A	48367873	3	1	181	1	0	0	0	0	1	0	0	0	3702	1159	40	1	155	1	COL2A1	12	48367873	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	2557296	48367873	85484022	141	34081											
LIMA1	51474	broad.mit.edu	37	chr12	50616056	50616056	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgacctgagtctagatctGgggtggatttgttcttcttg	5	16	14	6	0	4	3	0	2	4	1	4	4	4	4	1	4	0	1	1	4	1	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:50616056G>A	uc001rwj.3	-	4	552	c.378C>T	c.(376-378)CCC>CCT	p.P126P	LIMA1_uc001rwh.3_5'UTR|LIMA1_uc001rwi.3_5'UTR|LIMA1_uc001rwk.3_Silent_p.P126P|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	126					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						GTCTAGATCTGGGGTGGATTT	0.512													11	60					0	0	0	0	A	50616056	A	A	50616056	2	1	181	1	0	0	0	0	0	0	0	1	8837	1335	47	4		4	LIMA1	12	50616056	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	2248183	50616056	83235839	142	34082											
KRT79	338785	broad.mit.edu	37	chr12	53227934	53227934	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccactgctccgagacacCgtcactgagctgaagctggt	8	8	11	14	2	1	3	1	2	0	1	2	4	2	3	3	1	4	3	3	1	1	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:53227934C>T	uc001sbb.2	-	1	144	c.111G>A	c.(109-111)ACG>ACA	p.T37T		NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	37	Head.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						TCCGAGACACCGTCACTGAGC	0.637													5	53					0	0	0	0	T	53227934	T	T	53227934	2	4	181	1	0	0	0	0	0	0	0	1	8531	639	23	1		1	KRT79	12	53227934	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	2611878	53227934	80623961	143	34083											
NAV3	89795	broad.mit.edu	37	chr12	78531084	78531084	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgtgggagtgccacttcTctggaggaaagacctcgtgc	7	11	13	10	1	1	1	0	0	1	1	3	4	1	4	2	3	2	0	2	3	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:78531084T>G	uc001syp.2	+	19	4742	c.4569T>G	c.(4567-4569)TCT>TCG	p.S1523S	NAV3_uc001syo.2_Silent_p.S1523S|NAV3_uc010sub.1_Silent_p.S1009S|NAV3_uc009zsf.2_Silent_p.S354S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1523	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GTGCCACTTCTCTGGAGGAAA	0.512										HNSCC(70;0.22)			8	48					0	0	0	0	G	78531084	G	G	78531084	2	3	181	1	0	0	0	0	0	0	0	1	10238	1538	54	5		5	NAV3	12	78531084	Silent	SNP	T	TCGA-CV-5970-01A-11D-1683-08	25303150	78531084	55320811	144	34084											
LRRIQ1	84125	broad.mit.edu	37	chr12	85554449	85554449	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aataaagtgtctcttccaaaAtcaccaaagatggtacagcc	16	9	6	10	0	2	1	1	0	1	1	4	1	3	1	3	1	2	1	3	1	7	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:85554449A>C	uc001tac.2	+	24	4890	c.4779A>C	c.(4777-4779)AAA>AAC	p.K1593N		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1593										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CTCTTCCAAAATCACCAAAGA	0.338													5	58					0	0	0	0	C	85554449	C	C	85554449	3	2	181	1	0	0	0	0	1	0	0	0	9079	98	4	5	4873	5	LRRIQ1	12	85554449	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08	7023365	85554449	48297446	145	34085											
VEZT	55591	broad.mit.edu	37	chr12	95694420	95694420	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaagaacaaataatagaaGaaaataaaaatgagatagaa	27	5	8	1	0	0	5	0	1	0	5	0	7	0	6	0	1	1	0	0	1	13	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:95694420G>C	uc001tdz.2	+	12	2416	c.2311G>C	c.(2311-2313)GAA>CAA	p.E771Q	VEZT_uc009ztb.1_RNA|VEZT_uc009ztc.1_Missense_Mutation_p.E136Q|VEZT_uc001tdy.2_RNA	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	771						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						AATAATAGAAGAAAATAAAAA	0.383													4	23					0	0	0	0	C	95694420	C	C	95694420	3	2	181	1	0	0	0	0	1	0	0	0	17224	943	33	2	2357	2	VEZT	12	95694420	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	10139971	95694420	38157475	146	34086											
NEDD1	121441	broad.mit.edu	37	chr12	97328772	97328772	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtctgttcggcacttgaagTactccttgtttaagaaatca	11	14	8	8	1	2	2	1	1	1	1	4	2	3	2	1	1	1	4	1	1	4	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:97328772T>C	uc001teu.3	+	7	847	c.508T>C	c.(508-510)TAC>CAC	p.Y170H	NEDD1_uc001tev.3_Missense_Mutation_p.Y170H|NEDD1_uc010svc.1_Missense_Mutation_p.Y81H|NEDD1_uc001tew.2_Missense_Mutation_p.Y177H|NEDD1_uc001tex.2_Missense_Mutation_p.Y81H	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	170	WD 5.			Y -> C (in Ref. 1; BAC04099).	cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						GCACTTGAAGTACTCCTTGTT	0.328													13	75					0	0	0	0	C	97328772	C	C	97328772	3	2	181	1	0	0	0	0	1	0	0	0	10363	1638	57	5	551	5	NEDD1	12	97328772	Missense_Mutation	SNP	T	TCGA-CV-5970-01A-11D-1683-08	1634352	97328772	36523123	147	34087											
UBE3B	89910	broad.mit.edu	37	chr12	109972546	109972546	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgtcctccgcgagaagctgCgctacgccatcagcatgaac	9	6	11	15	5	1	2	1	1	0	1	3	3	3	2	3	0	5	3	3	0	3	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:109972546C>T	uc001top.2	+	28	3769	c.3166C>T	c.(3166-3168)CGC>TGC	p.R1056C	UBE3B_uc001toq.2_Missense_Mutation_p.R1056C|UBE3B_uc001tos.2_Missense_Mutation_p.R483C|UBE3B_uc001tot.2_Missense_Mutation_p.R174C|UBE3B_uc010sxp.1_3'UTR	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	1056	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CGAGAAGCTGCGCTACGCCAT	0.642													9	51					0	0	0	0	T	109972546	T	T	109972546	3	4	181	1	0	0	0	0	1	0	0	0	16948	768	27	1	3268	1	UBE3B	12	109972546	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	12643774	109972546	23879349	148	34088											
RPLP0	6175	broad.mit.edu	37	chr12	120636693	120636693	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccctggagattttagtggtGatacctaaagcctggaaaaa	13	10	10	8	0	0	2	0	1	0	1	0	4	0	3	4	3	2	0	4	3	6	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:120636693G>A	uc001txp.2	-	5	666	c.429C>T	c.(427-429)ATC>ATT	p.I143I	RPLP0_uc001txq.2_Silent_p.I143I|RPLP0_uc001txr.2_Silent_p.I143I|uc001txs.1_5'Flank	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	143					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTTTAGTGGTGATACCTAAAG	0.552													5	32					0	0	0	0	A	120636693	A	A	120636693	2	1	181	1	0	0	0	0	0	0	0	1	13669	1280	45	2		2	RPLP0	12	120636693	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	10664147	120636693	13215202	149	34089											
GPR133	283383	broad.mit.edu	37	chr12	131498863	131498863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcgggctctccactcattaCggtccacctcaagcacagat	9	9	8	15	2	3	1	2	0	1	1	6	1	4	1	3	2	2	2	3	2	2	1	rs149266247	byFrequency	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr12:131498863C>T	uc001uit.3	+	13	2010	c.1451C>T	c.(1450-1452)ACG>ATG	p.T484M	GPR133_uc010tbm.1_Missense_Mutation_p.T516M	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	484	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CCACTCATTACGGTCCACCTC	0.587													10	47					0	0	0	0	T	131498863	T	T	131498863	3	4	181	1	0	0	0	0	1	0	0	0	6681	536	19	1	1501	1	GPR133	12	131498863	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	10862170	131498863	2353032	150	34090											
PCDH17	27253	broad.mit.edu	37	chr13	58208055	58208055	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaactccaccaagtcgttcGcgatcaagattctagacgag	12	9	8	12	4	3	2	2	0	1	2	6	4	4	2	2	0	1	1	2	0	4	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr13:58208055G>T	uc001vhq.1	+	1	2267	c.1375G>T	c.(1375-1377)GCG>TCG	p.A459S	PCDH17_uc010aec.1_Missense_Mutation_p.A459S	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	459	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CAAGTCGTTCGCGATCAAGAT	0.607													3	19					2.56e-06	2.67677e-06	1	0	T	58208055	T	T	58208055	3	4	181	1	0	0	0	0	1	0	0	0	11566	1087	38	3	1377	3	PCDH17	13	58208055	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08		58208055	56961823	151	34091											
GPR18	2841	broad.mit.edu	37	chr13	99907960	99907960	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcatatagatggttaccGtggttctcttcttggtggta	7	17	10	7	1	4	1	2	0	2	1	5	1	4	1	1	4	1	3	1	4	4	7			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr13:99907960G>A	uc001voe.3	-	3	668	c.167C>T	c.(166-168)ACG>ATG	p.T56M	UBAC2_uc001voa.3_Intron|UBAC2_uc010tiu.1_Intron|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Intron|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_Intron|GPR18_uc010afv.2_Missense_Mutation_p.T56M	NM_005292	NP_005283	Q14330	GPR18_HUMAN	G protein-coupled receptor 18	56	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	GATGGTTACCGTGGTTCTCTT	0.348													28	56					0	0	0	0	A	99907960	A	A	99907960	3	1	181	1	0	0	0	0	1	0	0	0	6713	1145	40	1	832	1	GPR18	13	99907960	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	41699905	99907960	15261918	152	34092											
PCID2	55795	broad.mit.edu	37	chr13	113832567	113832567	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgctgaccaccagcttcTgatgctgatgcgatatgtag	8	12	11	10	1	1	3	0	3	1	0	1	4	1	3	2	0	4	5	2	0	2	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr13:113832567T>A	uc010tju.1	-	14	1226	c.1145A>T	c.(1144-1146)CAG>CTG	p.Q382L	PCID2_uc001vtb.2_Missense_Mutation_p.Q215L|PCID2_uc010tjv.1_Missense_Mutation_p.Q382L|PCID2_uc010tjw.1_Missense_Mutation_p.Q382L|PCID2_uc001vte.2_Missense_Mutation_p.Q275L|PCID2_uc001vtd.2_Missense_Mutation_p.Q275L|PCID2_uc001vtf.2_Missense_Mutation_p.Q275L	NM_001127203	NP_001120675	Q5JVF3	PCID2_HUMAN	PCI domain containing 2	382	PCI.				negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)			CACCAGCTTCTGATGCTGATG	0.522													25	26					0	0	0	0	A	113832567	A	A	113832567	3	1	181	1	0	0	0	0	1	0	0	0	11633	1580	55	5	58	5	PCID2	13	113832567	Missense_Mutation	SNP	T	TCGA-CV-5970-01A-11D-1683-08	13924607	113832567	1337311	153	34093											
DHRS4	10901	broad.mit.edu	37	chr14	24424278	24424278	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcgcccggcgtttggcccagGacggggcccatgtggtcgtc	3	8	16	14	5	0	0	0	0	0	0	3	1	0	1	3	6	0	1	3	6	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr14:24424278G>T	uc001wla.2	+	2	196	c.163G>T	c.(163-165)GAC>TAC	p.D55Y	C14orf167_uc001wkz.2_5'Flank|C14orf167_uc001wky.2_5'Flank|C14orf167_uc001wkx.2_5'Flank|C14orf167_uc010akx.1_RNA|DHRS4_uc010aky.2_Missense_Mutation_p.D55Y|DHRS4_uc001wlb.2_Missense_Mutation_p.D55Y|DHRS4_uc010akz.2_Missense_Mutation_p.D55Y|DHRS4_uc001wlc.3_Missense_Mutation_p.D55Y|DHRS4L2_uc001wld.3_Missense_Mutation_p.D55Y|DHRS4L2_uc001wle.3_Missense_Mutation_p.D55Y	NM_021004	NP_066284	Q9BTZ2	DHRS4_HUMAN	peroxisomal short-chain alcohol dehydrogenase	55	NADP (By similarity).					mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	TTTGGCCCAGGACGGGGCCCA	0.557													15	81					8.60227e-14	9.42455e-14	1	0	T	24424278	T	T	24424278	3	4	181	1	0	0	0	0	1	0	0	0	4514	1174	41	2	169	2	DHRS4	14	24424278	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08		24424278	82925262	154	34094											
CPNE6	9362	broad.mit.edu	37	chr14	24546188	24546188	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaaccgtgtggctgagccGgcccagcgggagcagagcac	9	4	15	13	3	1	2	1	1	0	1	1	3	1	3	3	3	5	3	3	3	1	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr14:24546188G>A	uc001wll.2	+	14	1365	c.1266G>A	c.(1264-1266)CCG>CCA	p.P422P	CPNE6_uc010tnv.1_Silent_p.P477P|CPNE6_uc001wlm.2_Silent_p.P247P|CPNE6_uc001wln.2_Silent_p.P90P	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	422	VWFA.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		TGGCTGAGCCGGCCCAGCGGG	0.637													5	24					0	0	0	0	A	24546188	A	A	24546188	2	1	181	1	0	0	0	0	0	0	0	1	3831	1103	39	1		1	CPNE6	14	24546188	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	121910	24546188	82803352	155	34095											
SDCCAG1	9147	broad.mit.edu	37	chr14	50262630	50262630	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaacgcttctaaatctcctGagtcacttggaagttttttc	9	16	6	10	1	3	1	1	1	2	0	5	2	3	2	1	1	1	2	1	1	4	7			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr14:50262630G>C	uc001wxc.2	-	26	2566	c.2498C>G	c.(2497-2499)TCA>TGA	p.S833*	SDCCAG1_uc010anj.1_Nonsense_Mutation_p.S833*|SDCCAG1_uc001wwz.2_Nonsense_Mutation_p.S33*|SDCCAG1_uc001wxa.2_Nonsense_Mutation_p.S113*|SDCCAG1_uc010tqi.1_Nonsense_Mutation_p.S812*|SDCCAG1_uc001wxe.2_Nonsense_Mutation_p.S791*|SDCCAG1_uc001wxd.1_Nonsense_Mutation_p.S238*	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	833						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		TAAATCTCCTGAGTCACTTGG	0.338													7	45					0	0	0	0	C	50262630	C	C	50262630	4	2	181	1	0	0	0	0	0	1	0	0	14022	1294	45	2	764	2	SDCCAG1	14	50262630	Nonsense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	25716442	50262630	57086910	156	34096											
C14orf101	54916	broad.mit.edu	37	chr14	57101623	57101623	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgtaactacaggtttgaTccatcttcttgggaatctgt	8	17	8	8	0	4	1	0	1	4	0	5	2	5	2	1	2	2	2	1	2	3	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr14:57101623T>G	uc001xcm.2	+	14	1853	c.1731T>G	c.(1729-1731)GAT>GAG	p.D577E	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_Missense_Mutation_p.D110E|C14orf101_uc001xco.2_Missense_Mutation_p.D110E	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	577						integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		ACAGGTTTGATCCATCTTCTT	0.294													20	62					0	0	0	0	G	57101623	G	G	57101623	3	3	181	1	0	0	0	0	1	0	0	0	1740	1432	50	5	1785	5	C14orf101	14	57101623	Missense_Mutation	SNP	T	TCGA-CV-5970-01A-11D-1683-08	6838993	57101623	50247917	157	34097											
NEK9	91754	broad.mit.edu	37	chr14	75567725	75567725	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaatggtaaactcatcacCgcaggagaccctgatcactt	13	8	8	12	1	3	2	3	1	0	1	3	3	3	2	2	2	2	3	2	2	3	2	rs151072111		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr14:75567725C>T	uc001xrl.2	-	16	2126	c.1972G>A	c.(1972-1974)GGT>AGT	p.G658S	NEK9_uc001xrk.2_Missense_Mutation_p.G158S	NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	658	RCC1 5.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)		AACTCATCACCGCAGGAGACC	0.517													21	33					0	0	0	0	T	75567725	T	T	75567725	3	4	181	1	0	0	0	0	1	0	0	0	10385	652	23	1	995	1	NEK9	14	75567725	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	18466102	75567725	31781815	158	34098											
ISM2	145501	broad.mit.edu	37	chr14	77942421	77942421	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacttgattaggaagtcgctCttgcagttcagccacttctc	8	14	8	11	1	3	1	1	1	2	0	5	2	3	2	1	1	3	3	1	1	3	6			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr14:77942421C>G	uc001xtz.2	-	7	1307	c.1233G>C	c.(1231-1233)AAG>AAC	p.K411N	ISM2_uc001xua.2_3'UTR|ISM2_uc001xty.2_Missense_Mutation_p.K323N|ISM2_uc010tvl.1_Missense_Mutation_p.K330N	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	411	AMOP.					extracellular region				skin(1)	1						GGAAGTCGCTCTTGCAGTTCA	0.612													9	46					0	0	0	0	G	77942421	G	G	77942421	3	3	181	1	0	0	0	0	1	0	0	0	7900	912	32	2	486	2	ISM2	14	77942421	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	2374696	77942421	29407119	159	34099											
TRPM1	4308	broad.mit.edu	37	chr15	31295039	31295039	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacaagctgtagccatcagcGctattgatgctgctttgccg	8	12	10	11	2	1	1	1	1	0	0	1	1	1	1	2	0	7	5	2	0	4	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr15:31295039G>A	uc001zfm.2	-	27	3926	c.3798C>T	c.(3796-3798)AGC>AGT	p.S1266S	TRPM1_uc010azy.2_Silent_p.S1173S|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1266	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AGCCATCAGCGCTATTGATGC	0.488													13	56					0	0	0	0	A	31295039	A	A	31295039	2	1	181	1	0	0	0	0	0	0	0	1	16652	1078	38	1		1	TRPM1	15	31295039	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08		31295039	71236353	160	34100											
ZNF592	9640	broad.mit.edu	37	chr15	85327115	85327115	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcctgatgatccaagtaaGtcccctgttgggtcacctct	8	12	9	12	0	2	2	1	2	1	0	5	3	5	2	5	1	0	2	5	1	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr15:85327115G>C	uc002bld.2	+	4	1545	c.1209G>C	c.(1207-1209)AAG>AAC	p.K403N	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	403					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ATCCAAGTAAGTCCCCTGTTG	0.532													6	33					0	0	0	0	C	85327115	C	C	85327115	3	2	181	1	0	0	0	0	1	0	0	0	18089	1020	36	4	1211	4	ZNF592	15	85327115	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	54032076	85327115	17204277	161	34101											
NTRK3	4916	broad.mit.edu	37	chr15	88483978	88483978	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctctcctcttaatgtgcTgcacatctgtaggatgggga	7	14	11	9	0	3	0	0	0	3	0	5	2	4	2	1	3	2	3	1	3	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr15:88483978T>C	uc002bme.1	-	14	1754	c.1592A>G	c.(1591-1593)CAG>CGG	p.Q531R	NTRK3_uc002bmh.2_Missense_Mutation_p.Q523R|NTRK3_uc002bmf.1_Missense_Mutation_p.Q531R|NTRK3_uc010upl.1_Missense_Mutation_p.Q433R|NTRK3_uc010bnh.1_Missense_Mutation_p.Q523R	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	531	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTTAATGTGCTGCACATCTGT	0.537			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			20	78					0	0	0	0	C	88483978	C	C	88483978	3	2	181	1	0	0	0	0	1	0	0	0	10762	1580	55	5	951	5	NTRK3	15	88483978	Missense_Mutation	SNP	T	TCGA-CV-5970-01A-11D-1683-08	3156863	88483978	14047414	162	34102											
HAPLN3	145864	broad.mit.edu	37	chr15	89424833	89424833	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaccatttgacacgcacaCgccgcggggagaccagggcc	9	4	12	16	4	0	2	0	1	0	1	1	3	1	2	5	3	0	1	5	3	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr15:89424833C>T	uc002bnc.2	-	3	376	c.248G>A	c.(247-249)CGT>CAT	p.R83H	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Missense_Mutation_p.R145H	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	83	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					GACACGCACACGCCGCGGGGA	0.657													20	58					0	0	0	0	T	89424833	T	T	89424833	3	4	181	1	0	0	0	0	1	0	0	0	6995	536	19	1	846	1	HAPLN3	15	89424833	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	940855	89424833	13106559	163	34103											
SYNM	23336	broad.mit.edu	37	chr15	99672905	99672905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttagcagacagcagcagaaCgctaaggcacattgcaccag	14	5	11	11	1	0	2	0	0	0	2	0	2	0	2	1	1	5	7	1	1	3	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr15:99672905C>T	uc002bup.2	+	6	4460	c.4340C>T	c.(4339-4341)ACG>ATG	p.T1447M	SYNM_uc002buo.2_Intron|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	1447	Tail.|Interaction with DMD and UTRN.|Interaction with TLN1 and VCL.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						AGCAGCAGAACGCTAAGGCAC	0.542													33	114					0	0	0	0	T	99672905	T	T	99672905	3	4	181	1	0	0	0	0	1	0	0	0	15521	536	19	1	4353	1	SYNM	15	99672905	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	10248072	99672905	2858487	164	34104											
MEF2A	4205	broad.mit.edu	37	chr15	100250868	100250868	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccagcgctgacctgtcaGcccttcaaggcttcaactcg	8	9	9	15	2	3	2	3	2	0	0	4	2	3	2	3	1	3	2	3	1	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr15:100250868G>T	uc010urw.1	+	10	1404	c.1045G>T	c.(1045-1047)GCC>TCC	p.A349S	MEF2A_uc010urv.1_Missense_Mutation_p.A279S|MEF2A_uc010bos.2_Missense_Mutation_p.A339S|MEF2A_uc002bvf.2_Missense_Mutation_p.A341S|MEF2A_uc002bve.2_Missense_Mutation_p.A347S|MEF2A_uc002bvg.2_Missense_Mutation_p.A339S|MEF2A_uc002bvi.2_Missense_Mutation_p.A339S|MEF2A_uc010bot.2_Missense_Mutation_p.A271S	NM_005587	NP_005578	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A isoform 1	349					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			ovary(1)	1	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			TGACCTGTCAGCCCTTCAAGG	0.527													4	20					0.00909568	0.0092509	1	0	T	100250868	T	T	100250868	3	4	181	1	0	0	0	0	1	0	0	0	9508	971	34	4	1215	4	MEF2A	15	100250868	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	577963	100250868	2280524	165	34105											
MSLN	10232	broad.mit.edu	37	chr16	818647	818647	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcacccctctctctgtaGaggccctctcggggacgccc	5	8	11	17	2	4	1	1	0	3	1	6	3	4	2	4	3	0	1	4	3	1	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:818647G>T	uc002cjw.1	+	17	1859	c.1808_splice	c.e17-1	p.E603_splice	MSLN_uc002cjt.1_Splice_Site_p.E595_splice|MSLN_uc002cju.1_Splice_Site_p.E595_splice|MSLN_uc010brd.1_Splice_Site_p.E594_splice|MSLN_uc002cjv.1_Intron|MSLN_uc002cjx.1_Splice_Site_p.E595_splice|MSLN_uc002cjy.1_Missense_Mutation_p.R287I|MIR662_hsa-mir-662|MI0003670_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein						cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				TCTCTCTGTAGAGGCCCTCTC	0.697													12	52					4.3838e-07	4.61616e-07	1	0	T	818647	T	T	818647	5	4	181	1	0	0	0	0	0	0	1	0	9934	956	33	2	1869	2	MSLN	16	818647	Splice_Site	SNP	G	TCGA-CV-5970-01A-11D-1683-08		818647	89536106	166	34106											
GRIN2A	2903	broad.mit.edu	37	chr16	9934948	9934948	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcttcacattcatcccctCattggttgaattgctgtaaa	9	17	5	10	0	4	1	3	1	1	0	5	1	5	1	2	1	1	3	2	1	3	7			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:9934948C>T	uc002czo.3	-	6	1890	c.1342G>A	c.(1342-1344)GAG>AAG	p.E448K	GRIN2A_uc010uym.1_Missense_Mutation_p.E448K|GRIN2A_uc010uyn.1_Missense_Mutation_p.E291K|GRIN2A_uc002czr.3_Missense_Mutation_p.E448K	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	448	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTCATCCCCTCATTGGTTGAA	0.254													14	60					0	0	0	0	T	9934948	T	T	9934948	3	4	181	1	0	0	0	0	1	0	0	0	6818	835	29	2	3084	2	GRIN2A	16	9934948	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	9116301	9934948	80419805	167	34107											
SH2B1	25970	broad.mit.edu	37	chr16	28883644	28883644	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggcggcactggctcccaCggtgtcttcctggtgcgcca	4	9	13	15	3	1	0	0	0	1	0	3	0	3	0	3	5	1	2	3	5	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:28883644C>T	uc002dri.2	+	9	2086	c.1647C>T	c.(1645-1647)CAC>CAT	p.H549H	uc010vct.1_Intron|SH2B1_uc010vdc.1_Silent_p.H239H|SH2B1_uc002drj.2_Silent_p.H549H|SH2B1_uc002drk.2_Silent_p.H549H|SH2B1_uc002drl.2_Silent_p.H549H|SH2B1_uc010vdd.1_Silent_p.H213H|SH2B1_uc010vde.1_Silent_p.H549H|SH2B1_uc002drm.2_Silent_p.H549H	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	549	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|SH2.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						CTGGCTCCCACGGTGTCTTCC	0.622													10	37					0	0	0	0	T	28883644	T	T	28883644	2	4	181	1	0	0	0	0	0	0	0	1	14292	535	19	1		1	SH2B1	16	28883644	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	18948696	28883644	61471109	168	34108											
NKD1	85407	broad.mit.edu	37	chr16	50583366	50583366	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtgagcgctgcctgggctcGgaagggcatcgaggagtgga	7	6	19	9	4	0	1	0	1	0	0	2	5	0	4	1	5	2	3	1	5	1	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:50583366G>A	uc002egg.1	+	3	316	c.92G>A	c.(91-93)CGG>CAG	p.R31Q		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	31					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		GCCTGGGCTCGGAAGGGCATC	0.692													6	21					0	0	0	0	A	50583366	A	A	50583366	3	1	181	1	0	0	0	0	1	0	0	0	10495	1116	39	1	102	1	NKD1	16	50583366	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	21699722	50583366	39771387	169	34109											
CNGB1	1258	broad.mit.edu	37	chr16	58001097	58001097	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccacctccgcctccatctCtggctctggttccacttcct	3	14	5	19	1	2	0	0	0	2	0	8	0	7	0	7	2	0	2	7	2	0	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:58001097C>G	uc002emt.2	-	2	159	c.94G>C	c.(94-96)GAG>CAG	p.E32Q	CNGB1_uc010cdh.2_Missense_Mutation_p.E32Q|CNGB1_uc002emu.2_Missense_Mutation_p.E32Q	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	32	Glu-rich.				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GCCTCCATCTCTGGCTCTGGT	0.637													10	45					0	0	0	0	G	58001097	G	G	58001097	3	3	181	1	0	0	0	0	1	0	0	0	3615	922	32	2	3819	2	CNGB1	16	58001097	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	7417731	58001097	32353656	170	34110											
CDH11	1009	broad.mit.edu	37	chr16	65032724	65032724	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcccctgagagaatgtatttAatgttcccatcaccagagtc	11	12	7	11	0	1	3	1	1	0	2	4	4	3	3	4	0	0	2	4	0	3	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:65032724A>G	uc002eoi.2	-	4	698	c.264T>C	c.(262-264)ATT>ATC	p.I88I	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.I88I|CDH11_uc010vin.1_5'UTR|CDH11_uc010vio.1_Silent_p.I88I	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	88	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GAATGTATTTAATGTTCCCAT	0.408			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			7	36					0	0	0	0	G	65032724	G	G	65032724	2	3	181	1	0	0	0	0	0	0	0	1	3112	358	13	5		5	CDH11	16	65032724	Silent	SNP	A	TCGA-CV-5970-01A-11D-1683-08	7031627	65032724	25322029	171	34111											
NFATC3	4775	broad.mit.edu	37	chr16	68200760	68200760	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctttagtattgattgtgcagGtattttgaaactccgcaatt	10	17	8	6	1	0	2	0	2	0	0	1	2	1	2	1	1	2	4	1	1	5	9			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:68200760G>C	uc002evo.1	+	5	1826	c.1616G>C	c.(1615-1617)GGT>GCT	p.G539A	NFATC3_uc010vkl.1_Missense_Mutation_p.G60A|NFATC3_uc010vkm.1_Missense_Mutation_p.G60A|NFATC3_uc010vkn.1_Missense_Mutation_p.G60A|NFATC3_uc010vko.1_Missense_Mutation_p.G60A|NFATC3_uc010vkp.1_Missense_Mutation_p.G60A|NFATC3_uc010vkq.1_Missense_Mutation_p.G60A|NFATC3_uc002evl.2_Missense_Mutation_p.G60A|NFATC3_uc002evk.2_Missense_Mutation_p.G539A|NFATC3_uc002evm.1_Missense_Mutation_p.G539A|NFATC3_uc002evn.1_Missense_Mutation_p.G539A|NFATC3_uc010vkr.1_Missense_Mutation_p.G60A|NFATC3_uc010vks.1_Missense_Mutation_p.G60A|NFATC3_uc010vkt.1_Missense_Mutation_p.G60A|NFATC3_uc010vku.1_Missense_Mutation_p.G60A|NFATC3_uc010vkv.1_Missense_Mutation_p.G60A|NFATC3_uc010vkw.1_Missense_Mutation_p.G60A|NFATC3_uc010vkx.1_Missense_Mutation_p.G60A|NFATC3_uc010vky.1_Missense_Mutation_p.G60A|NFATC3_uc010vkz.1_Missense_Mutation_p.G60A|NFATC3_uc010vla.1_Missense_Mutation_p.G60A|NFATC3_uc010vlb.1_Missense_Mutation_p.G60A|NFATC3_uc010vlc.1_Missense_Mutation_p.G60A	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	539	RHD.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		GATTGTGCAGGTATTTTGAAA	0.299													7	19					0	0	0	0	C	68200760	C	C	68200760	3	2	181	1	0	0	0	0	1	0	0	0	10418	1261	44	4	1634	4	NFATC3	16	68200760	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	3168036	68200760	22153993	172	34112											
HYDIN	54768	broad.mit.edu	37	chr16	70952161	70952162	+	Frame_Shift_Ins	INS	-	T	T																															tctgattctatttccatttcINSttttttttcatccagagata																										TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:70952161_70952162insT	uc002ezr.2	-	47	8081_8082	c.7953_7954insA	c.(7951-7956)AAAGAAfs	p.K2651fs		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2652_2653										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ATTTCCATTTCTTTTTTTTCAT	0.45													---	---	---								T	70952162	T	T	70952161	7	5	181	1	0	1	1	0	0	0	0	0	7506	922	32	0	7568	0	HYDIN	16	70952161	Frame_Shift_Ins	INS	-	TCGA-CV-5970-01A-11D-1683-08	2751401	70952161	19402592	173	34113											
ADAMTS18	170692	broad.mit.edu	37	chr16	77325197	77325197	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaataccatccagctaccAtgttgtacactggatgggct	11	11	9	10	0	0	1	0	1	0	0	1	2	1	2	3	2	4	4	3	2	4	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:77325197A>C	uc002ffc.3	-	21	3787	c.3368T>G	c.(3367-3369)ATG>AGG	p.M1123R		NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1123	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TCCAGCTACCATGTTGTACAC	0.502													16	86					0	0	0	0	C	77325197	C	C	77325197	3	2	181	1	0	0	0	0	1	0	0	0	263	217	8	5	309	5	ADAMTS18	16	77325197	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08	6373036	77325197	13029556	174	34114											
WFDC1	58189	broad.mit.edu	37	chr16	84353096	84353096	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctctgtccctcgggctatGagtgccacatcctgagccca	6	10	10	15	1	1	2	0	2	1	0	4	2	3	2	4	1	3	2	4	1	1	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:84353096G>A	uc002fhw.2	+	4	658	c.481G>A	c.(481-483)GAG>AAG	p.E161K	WFDC1_uc002fhv.2_Missense_Mutation_p.E161K	NM_021197	NP_067020	Q9HC57	WFDC1_HUMAN	WAP four-disulfide core domain 1 precursor	161					negative regulation of cell growth	extracellular space	serine-type endopeptidase inhibitor activity			breast(1)	1						CTCGGGCTATGAGTGCCACAT	0.667													13	36					0	0	0	0	A	84353096	A	A	84353096	3	1	181	1	0	0	0	0	1	0	0	0	17414	1291	45	2	495	2	WFDC1	16	84353096	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	7027899	84353096	6001657	175	34115											
FOXL1	2300	broad.mit.edu	37	chr16	86612542	86612542	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgcccgagcagagggtcacGctcaacggcatctaccagtt	9	6	12	14	4	3	1	2	0	1	1	3	2	3	1	2	2	3	4	2	2	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:86612542G>A	uc002fjr.2	+	1	428	c.213G>A	c.(211-213)ACG>ACA	p.T71T		NM_005250	NP_005241	Q12952	FOXL1_HUMAN	forkhead box L1	71	Fork-head.				brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1						AGAGGGTCACGCTCAACGGCA	0.642													27	72					0	0	0	0	A	86612542	A	A	86612542	2	1	181	1	0	0	0	0	0	0	0	1	6050	1074	38	1		1	FOXL1	16	86612542	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	2259446	86612542	3742211	176	34116											
DEF8	54849	broad.mit.edu	37	chr16	90016035	90016035	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcacgccgcgggcaggacGcgggaggccaggtccgtgca	6	3	19	13	6	1	0	1	0	0	0	2	2	2	2	3	6	1	2	3	6	0	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr16:90016035G>A	uc002fpn.1	+	2	251	c.162G>A	c.(160-162)ACG>ACA	p.T54T	DEF8_uc002fpl.2_Intron|DEF8_uc002fpm.2_Intron|DEF8_uc002fpo.1_Intron|DEF8_uc002fpp.1_Intron|DEF8_uc010vpq.1_Intron|DEF8_uc010vpr.1_Intron	NM_207514	NP_997397	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 isoform 1	54					intracellular signal transduction		zinc ion binding			central_nervous_system(1)	1		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CGGGCAGGACGCGGGAGGCCA	0.677													10	48					0	0	0	0	A	90016035	A	A	90016035	2	1	181	1	0	0	0	0	0	0	0	1	4404	1074	38	1		1	DEF8	16	90016035	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	3403493	90016035	338718	177	34117											
ZNF232	7775	broad.mit.edu	37	chr17	5009153	5009153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttctggcatgaactctcCgatgtctaatgagctctgag	8	14	9	10	1	4	3	0	3	4	0	5	4	4	3	1	1	2	2	1	1	2	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr17:5009153C>T	uc002gas.2	-	5	1974	c.1220G>A	c.(1219-1221)CGG>CAG	p.R407Q	ZNF232_uc002gar.1_Missense_Mutation_p.R425Q|ZNF232_uc002gat.2_Missense_Mutation_p.R434Q	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	407	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						ATGAACTCTCCGATGTCTAAT	0.433													16	67					0	0	0	0	T	5009153	T	T	5009153	3	4	181	1	0	0	0	0	1	0	0	0	17852	652	23	1	37	1	ZNF232	17	5009153	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08		5009153	76186057	178	34118											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	6	9	15	11	2	1	2	1	2	0	0	2	3	2	3	4	4	2	2	4	4	0	1	rs11540652		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	16					0	0	0	0	T	7577538	T	T	7577538	3	4	181	1	0	0	0	0	1	0	0	0	16448	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	2568385	7577538	73617672	179	34119											
RAB34	83871	broad.mit.edu	37	chr17	27045165	27045165	+	5'Flank	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgaattggtgatggggaatcGgagactgctgcgcagcatct	9	9	15	8	3	1	2	0	1	1	1	2	5	1	3	0	4	3	3	0	4	2	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr17:27045165G>C	uc002hce.2	-						RAB34_uc002hcg.2_5'Flank|RAB34_uc002hcf.2_5'Flank|RAB34_uc010was.1_Missense_Mutation_p.R41G|RAB34_uc010wat.1_Missense_Mutation_p.R41G|RAB34_uc002hch.2_5'UTR|RAB34_uc010wau.1_5'UTR|RAB34_uc010wav.1_Missense_Mutation_p.R41G|RPL23A_uc002hci.2_5'Flank|SNORD42B_uc002hcj.1_5'Flank|RPL23A_uc002hck.1_5'Flank	NM_031934	NP_114140	Q9BZG1	RAB34_HUMAN	Ras-related protein RAB34 isoform 1						protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	Lung NSC(42;0.00431)					ATGGGGAATCGGAGACTGCTG	0.632													5	12					0	0	0	0	C	27045165	C	C	27045165	1	2	181	0	1	0	0	0	0	0	0	0	12989	1124	39	3		3	RAB34	17	27045165	5'Flank	SNP	G	TCGA-CV-5970-01A-11D-1683-08	19467627	27045165	54150045	180	34120											
CCL2	6347	broad.mit.edu	37	chr17	32583342	32583342	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaatcaccagcagcaagtgtCccaaagaagctgtgatgtga	14	7	11	9	0	1	3	1	2	0	1	2	4	2	3	2	0	3	3	2	0	4	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr17:32583342C>A	uc002hhy.2	+	2	251	c.178C>A	c.(178-180)CCC>ACC	p.P60T		NM_002982	NP_002973	P13500	CCL2_HUMAN	small inducible cytokine A2 precursor	60				Missing: 90% reduction in activity.|Missing: 83% reduction in activity.	angiogenesis|anti-apoptosis|apoptotic cell clearance|astrocyte cell migration|cell adhesion|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|G-protein signaling, coupled to cyclic nucleotide second messenger|helper T cell extravasation|humoral immune response|inflammatory response|JAK-STAT cascade|macrophage chemotaxis|monocyte chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of T cell activation|viral genome replication	extracellular space	CCR2 chemokine receptor binding|chemokine activity|protein kinase activity|signal transducer activity			pancreas(1)	1	Breast(3;0.00224)	Ovarian(249;0.0694)|Breast(31;0.151)|Lung NSC(157;0.153)		UCEC - Uterine corpus endometrioid carcinoma (308;0.000241)|BRCA - Breast invasive adenocarcinoma(366;0.0103)	Atorvastatin(DB01076)|Danazol(DB01406)|Mimosine(DB01055)|Simvastatin(DB00641)	CAGCAAGTGTCCCAAAGAAGC	0.493													14	30					1.3612e-06	1.4283e-06	1	0	A	32583342	A	A	32583342	3	1	181	1	0	0	0	0	1	0	0	0	2904	855	30	2	184	2	CCL2	17	32583342	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	5538177	32583342	48611868	181	34121											
GSDMB	55876	broad.mit.edu	37	chr17	38073560	38073560	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttgtgatttcctcaaataCgctgaacattgcgcctggac	9	13	8	11	2	2	2	1	2	1	0	3	3	3	3	2	1	3	1	2	1	3	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr17:38073560C>T	uc010cwj.2	-	1	15	c.10G>A	c.(10-12)GTA>ATA	p.V4I	GSDMB_uc010cwk.2_RNA|GSDMB_uc010cwl.2_RNA|GSDMB_uc010cwm.2_RNA|GSDMB_uc002htg.2_Missense_Mutation_p.V4I|GSDMB_uc002hth.2_Missense_Mutation_p.V4I|GSDMB_uc010wem.1_Missense_Mutation_p.V4I	NM_001042471	NP_001035936	Q8TAX9	GSDMB_HUMAN	gasdermin B isoform 1	4						cytoplasm				breast(1)|pancreas(1)	2						TCCTCAAATACGCTGAACATT	0.433													18	47					0	0	0	0	T	38073560	T	T	38073560	3	4	181	1	0	0	0	0	1	0	0	0	6856	536	19	1	1280	1	GSDMB	17	38073560	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	5490218	38073560	43121650	182	34122											
RPS6KB1	6198	broad.mit.edu	37	chr17	57990070	57990070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaacattgtgagaaatttGaaatctcagaaactagtgtg	15	12	10	4	0	1	3	1	2	1	2	2	5	1	4	0	1	2	0	0	1	5	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr17:57990070G>A	uc002ixy.2	+	3	320	c.217G>A	c.(217-219)GAA>AAA	p.E73K	RPS6KB1_uc010ddj.1_Missense_Mutation_p.E73K|RPS6KB1_uc010wom.1_Missense_Mutation_p.E20K|RPS6KB1_uc010won.1_Missense_Mutation_p.E73K|RPS6KB1_uc010woo.1_Missense_Mutation_p.E8K	NM_003161	NP_003152	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide	73					apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			large_intestine(1)	1	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			TGAGAAATTTGAAATCTCAGA	0.373													17	115					0	0	0	0	A	57990070	A	A	57990070	3	1	181	1	0	0	0	0	1	0	0	0	13721	1291	45	2	227	2	RPS6KB1	17	57990070	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	19916510	57990070	23205140	183	34123											
C17orf28	283987	broad.mit.edu	37	chr17	72959983	72959983	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtggcagccactctcagctCcctgcaccagcttctcaacg	8	8	8	17	1	2	0	2	0	2	0	5	0	3	0	3	1	5	4	3	1	1	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr17:72959983C>A	uc002jmj.3	-	3	388	c.239G>T	c.(238-240)GGA>GTA	p.G80V	C17orf28_uc010wrs.1_5'UTR|C17orf28_uc002jmk.2_Missense_Mutation_p.G80V	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	80						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					ACTCTCAGCTCCCTGCACCAG	0.652													12	32					1.15919e-05	1.20782e-05	1	0	A	72959983	A	A	72959983	3	1	181	1	0	0	0	0	1	0	0	0	1860	855	30	2	2195	2	C17orf28	17	72959983	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	14969913	72959983	8235227	184	34124											
EIF4A3	9775	broad.mit.edu	37	chr17	78120703	78120703	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactttagtcatgtcttcctCtttgagcagccgctttcgcg	5	15	8	13	3	3	1	1	1	2	0	5	1	4	1	2	0	2	2	2	0	1	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr17:78120703C>G	uc010wuc.1	-	2	131	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	EIF4A3_uc002jxs.2_Missense_Mutation_p.E20Q	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	20					mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			ATGTCTTCCTCTTTGAGCAGC	0.592													5	38					0	0	0	0	G	78120703	G	G	78120703	3	3	181	1	0	0	0	0	1	0	0	0	5050	922	32	2	1225	2	EIF4A3	17	78120703	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	5160720	78120703	3074507	185	34125											
RPTOR	57521	broad.mit.edu	37	chr17	78938109	78938109	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tactacatctccgtgtactcGgtggagaagcgtgtcagata	10	11	11	9	3	2	2	1	0	1	2	4	3	2	2	1	2	4	1	1	2	5	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr17:78938109G>A	uc002jyt.1	+	34	4792	c.3987G>A	c.(3985-3987)TCG>TCA	p.S1329S	RPTOR_uc010wug.1_Silent_p.S1171S|RPTOR_uc002jyu.1_Silent_p.S222S	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	1329	WD 7.				cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CCGTGTACTCGGTGGAGAAGC	0.652													19	36					0	0	0	0	A	78938109	A	A	78938109	2	1	181	1	0	0	0	0	0	0	0	1	13730	1103	39	1		1	RPTOR	17	78938109	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	817406	78938109	2257101	186	34126											
ADCYAP1	116	broad.mit.edu	37	chr18	908272	908272	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgcctccccgttagagatgtCgcccacgggatccttaacga	8	9	10	14	4	0	1	0	0	0	1	3	4	2	2	5	1	2	1	5	1	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr18:908272C>G	uc010dkg.2	+	4	368	c.249C>G	c.(247-249)GTC>GTG	p.V83V	ADCYAP1_uc010dkh.2_Silent_p.V83V	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	83					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						TTAGAGATGTCGCCCACGGGA	0.677													3	20					0	0	0	0	G	908272	G	G	908272	2	3	181	1	0	0	0	0	0	0	0	1	302	871	31	3		3	ADCYAP1	18	908272	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08		908272	77168976	187	34127											
ASXL3	80816	broad.mit.edu	37	chr18	31325516	31325516	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aacagcaaaagcggctgctcCcctcgtgtagcttccagcag	10	7	10	14	2	0	0	0	0	0	0	3	0	2	0	3	1	6	6	3	1	4	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr18:31325516C>G	uc010dmg.1	+	12	5759	c.5704C>G	c.(5704-5706)CCC>GCC	p.P1902A	ASXL3_uc002kxq.2_Missense_Mutation_p.P1609A	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1902					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GCGGCTGCTCCCCTCGTGTAG	0.498													6	93					0	0	0	0	G	31325516	G	G	31325516	3	3	181	1	0	0	0	0	1	0	0	0	1070	623	22	4	5750	4	ASXL3	18	31325516	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	30417244	31325516	46751732	188	34128											
SETBP1	26040	broad.mit.edu	37	chr18	42529990	42529990	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtccaccaactctgacagcGgacccgtcactcagaattgc	10	7	9	15	2	3	2	2	1	1	1	4	3	4	3	3	2	3	0	3	2	2	1	rs143196787		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr18:42529990G>T	uc010dni.2	+	4	981	c.685G>T	c.(685-687)GGA>TGA	p.G229*		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	229						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CTCTGACAGCGGACCCGTCAC	0.547									Schinzel-Giedion_syndrome				7	44					0.000157383	0.000162848	1	0	T	42529990	T	T	42529990	4	4	181	1	0	0	0	0	0	1	0	0	14194	1117	39	3	888	3	SETBP1	18	42529990	Nonsense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	11204474	42529990	35547258	189	34129											
CXXC1	30827	broad.mit.edu	37	chr18	47811188	47811188	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggtccaggaatggggactCttctgtgtcgctcatccagg	6	10	15	10	1	3	0	1	0	2	0	6	2	5	2	2	6	0	1	2	6	1	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr18:47811188C>T	uc002leq.3	-	8	1667	c.934G>A	c.(934-936)GAG>AAG	p.E312K	CXXC1_uc002lep.3_Missense_Mutation_p.E169K|CXXC1_uc002ler.3_Missense_Mutation_p.E312K|CXXC1_uc010doy.2_Missense_Mutation_p.E312K|CXXC1_uc002les.2_Missense_Mutation_p.E312K	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	312	Asp/Glu-rich (acidic).				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						AATGGGGACTCTTCTGTGTCG	0.493													4	18					0	0	0	0	T	47811188	T	T	47811188	3	4	181	1	0	0	0	0	1	0	0	0	4114	922	32	2	1080	2	CXXC1	18	47811188	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	5281198	47811188	30266060	190	34130			1	49		2	2	14	C		9.616208e-05
CXXC1	30827	broad.mit.edu	37	chr18	47811201	47811201	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggactcttctgtgtcgctCatccagggctgcaagcaggg	6	9	15	11	1	3	0	1	0	2	0	5	1	4	1	1	4	2	4	1	4	1	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr18:47811201C>T	uc002leq.3	-	8	1654	c.921G>A	c.(919-921)ATG>ATA	p.M307I	CXXC1_uc002lep.3_Missense_Mutation_p.M164I|CXXC1_uc002ler.3_Missense_Mutation_p.M307I|CXXC1_uc010doy.2_Missense_Mutation_p.M307I|CXXC1_uc002les.2_Missense_Mutation_p.M307I	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	307	Asp/Glu-rich (acidic).				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CTGTGTCGCTCATCCAGGGCT	0.527													5	17					0	0	0	0	T	47811201	T	T	47811201	3	4	181	1	0	0	0	0	1	0	0	0	4114	826	29	2	1093	2	CXXC1	18	47811201	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	13	47811201	30266047	191	34131			1	49		2	2	14	C		9.616208e-05
CCDC68	80323	broad.mit.edu	37	chr18	52571634	52571634	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaataaggggaaacaccttcGgtcttcaattcactgtagaa	15	10	8	8	1	3	1	2	0	1	1	4	2	3	2	1	3	1	1	1	3	6	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr18:52571634G>A	uc002lfs.2	-	12	1135	c.963C>T	c.(961-963)ACC>ACT	p.T321T	CCDC68_uc002lft.2_Silent_p.T321T	NM_001143829	NP_001137301	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	321										skin(1)	1				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		AAACACCTTCGGTCTTCAATT	0.368													7	23					0	0	0	0	A	52571634	A	A	52571634	2	1	181	1	0	0	0	0	0	0	0	1	2853	1103	39	1		1	CCDC68	18	52571634	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	4760433	52571634	25505614	192	34132											
MBD3	53615	broad.mit.edu	37	chr19	1581180	1581180	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttctccacggcggccgaGagctgtcccgtgatgggcat	5	10	13	13	4	2	2	0	1	2	1	4	3	3	2	3	3	1	2	3	3	0	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:1581180G>C	uc002ltl.1	-	5	610	c.588C>G	c.(586-588)CTC>CTG	p.L196L	MBD3_uc002ltj.2_Silent_p.L196L|MBD3_uc002ltk.2_Silent_p.L164L	NM_003926	NP_003917	O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	196					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			ovary(1)|pancreas(1)|skin(1)	3		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCGGCCGAGAGCTGTCCCG	0.652													5	14					0	0	0	0	C	1581180	C	C	1581180	2	2	181	1	0	0	0	0	0	0	0	1	9397	929	33	2		2	MBD3	19	1581180	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08		1581180	57547803	193	34133											
TNFSF14	8740	broad.mit.edu	37	chr19	6670018	6670018	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcttcgtcccagcctcgtGaatgggatgtcggtctgtcc	4	12	13	12	3	1	1	0	1	1	0	6	2	3	2	3	3	1	1	3	3	1	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:6670018G>A	uc002mfk.1	-	2	445	c.63C>T	c.(61-63)TTC>TTT	p.F21F	TNFSF14_uc002mfj.1_Silent_p.F21F	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	21	Cytoplasmic (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						CCAGCCTCGTGAATGGGATGT	0.642													19	80					0	0	0	0	A	6670018	A	A	6670018	2	1	181	1	0	0	0	0	0	0	0	1	16373	1281	45	2		2	TNFSF14	19	6670018	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	5088838	6670018	52458965	194	34134											
NDUFA7	4701	broad.mit.edu	37	chr19	8381382	8381382	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcgctggagatcctcacctCtctgctggcttgcctgacac	6	10	10	15	1	2	2	1	1	1	1	4	3	3	2	3	2	3	3	3	2	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:8381382C>G	uc002mjm.1	-	3	287	c.249G>C	c.(247-249)GAG>GAC	p.E83D		NM_005001	NP_004992	O95182	NDUA7_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	83					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	ATCCTCACCTCTCTGCTGGCT	0.587													15	82					0	0	0	0	G	8381382	G	G	8381382	3	3	181	1	0	0	0	0	1	0	0	0	10324	912	32	2	100	2	NDUFA7	19	8381382	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	1711364	8381382	50747601	195	34135											
KEAP1	9817	broad.mit.edu	37	chr19	10610149	10610149	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atctgctcagcgaagttggcGatgccgatggcattgctggg	7	10	15	9	3	2	0	1	0	1	0	2	3	2	0	1	3	4	4	1	3	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:10610149G>A	uc002moq.1	-	2	717	c.561C>T	c.(559-561)ATC>ATT	p.I187I	KEAP1_uc002mor.1_Silent_p.I187I	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	187	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CGAAGTTGGCGATGCCGATGG	0.592													4	44					0	0	0	0	A	10610149	A	A	10610149	2	1	181	1	0	0	0	0	0	0	0	1	8180	1048	37	1		1	KEAP1	19	10610149	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	2228767	10610149	48518834	196	34136											
ZNF653	115950	broad.mit.edu	37	chr19	11598248	11598248	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtccactgccggggacacCgctgcctgctgccatgttga	6	8	12	15	2	0	1	0	1	0	0	1	2	1	2	5	2	4	3	5	2	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:11598248C>T	uc002mrz.1	-	4	1083	c.1030G>A	c.(1030-1032)GGT>AGT	p.G344S		NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGGGGACACCGCTGCCTGCT	0.657													26	24					0	0	0	0	T	11598248	T	T	11598248	3	4	181	1	0	0	0	0	1	0	0	0	18133	652	23	1	841	1	ZNF653	19	11598248	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	988099	11598248	47530735	197	34137											
SYCE2	256126	broad.mit.edu	37	chr19	13029104	13029104	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgctccttgctctccccCaagggctgcggttcctggtc	3	11	12	15	1	1	0	0	0	1	0	5	1	3	1	4	4	3	4	4	4	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:13029104C>A	uc002mvr.2	-	2	78	c.63G>T	c.(61-63)TTG>TTT	p.L21F		NM_001105578	NP_001099048	Q6PIF2	SYCE2_HUMAN	synaptonemal complex central element protein 2	21					cell division	central element					0						TGCTCTCCCCCAAGGGCTGCG	0.602													13	41					1.05317e-09	1.12087e-09	1	0	A	13029104	A	A	13029104	3	1	181	1	0	0	0	0	1	0	0	0	15495	593	21	4	613	4	SYCE2	19	13029104	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	1430856	13029104	46099879	198	34138											
B3GNT3	10331	broad.mit.edu	37	chr19	17922878	17922878	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgagatgctgctcatgtggGatgcgctgaaccagcccaac	10	8	12	11	1	1	2	1	2	0	1	1	4	1	3	2	1	6	3	2	1	2	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:17922878G>A	uc002nhk.1	+	3	1151	c.1066G>A	c.(1066-1068)GAT>AAT	p.D356N	B3GNT3_uc002nhl.1_Missense_Mutation_p.D356N|B3GNT3_uc010ebd.1_Missense_Mutation_p.D356N|B3GNT3_uc010ebe.1_Missense_Mutation_p.D356N	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	356	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						GCTCATGTGGGATGCGCTGAA	0.587													21	45					0	0	0	0	A	17922878	A	A	17922878	3	1	181	1	0	0	0	0	1	0	0	0	1260	1174	41	2	1072	2	B3GNT3	19	17922878	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	4893774	17922878	41206105	199	34139											
LSM4	25804	broad.mit.edu	37	chr19	18420497	18420497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggagacccacctcggccagCgccgcccatgccgcggcctt	5	4	13	19	5	0	1	0	0	0	1	1	2	0	1	7	3	2	0	7	3	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:18420497C>T	uc002niq.2	-	4	490	c.319G>A	c.(319-321)GCT>ACT	p.A107T		NM_012321	NP_036453	Q9Y4Z0	LSM4_HUMAN	U6 snRNA-associated Sm-like protein 4	107					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|mRNA processing|RNA splicing	cytosol|U6 snRNP	protein binding|RNA binding				0						CCTCGGCCAGCGCCGCCCATG	0.682													9	40					0	0	0	0	T	18420497	T	T	18420497	3	4	181	1	0	0	0	0	1	0	0	0	9108	768	27	1	108	1	LSM4	19	18420497	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	497619	18420497	40708486	200	34140											
HAPLN4	404037	broad.mit.edu	37	chr19	19372352	19372352	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccagagcgcgccgggaccGagggccgcccgagcgcacac	7	0	16	18	7	0	1	0	0	0	1	0	4	0	2	5	2	2	1	5	2	0	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:19372352G>A	uc002nmb.2	-	2	79	c.24C>T	c.(22-24)CTC>CTT	p.L8L	HAPLN4_uc002nmc.2_Silent_p.L8L	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	8					cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			CGCCGGGACCGAGGGCCGCCC	0.766													4	10					0	0	0	0	A	19372352	A	A	19372352	2	1	181	1	0	0	0	0	0	0	0	1	6996	1045	37	1		1	HAPLN4	19	19372352	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	951855	19372352	39756631	201	34141											
C19orf47	126526	broad.mit.edu	37	chr19	40842076	40842076	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtcacccaccacggtcaCgcccagctcattcattatct	9	10	6	16	2	5	0	4	0	1	0	5	1	5	0	3	1	1	1	3	1	1	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:40842076C>T	uc002oni.3	-	4	275	c.274G>A	c.(274-276)GTG>ATG	p.V92M	C19orf47_uc002ong.2_Translation_Start_Site|C19orf47_uc002onh.2_Missense_Mutation_p.V25M	NM_178830	NP_849152	Q8N9M1	CS047_HUMAN	hypothetical protein LOC126526	92										ovary(1)|skin(1)	2			Lung(22;0.000636)			ACCACGGTCACGCCCAGCTCA	0.572													6	41					0	0	0	0	T	40842076	T	T	40842076	3	4	181	1	0	0	0	0	1	0	0	0	1939	536	19	1	1018	1	C19orf47	19	40842076	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	21469724	40842076	18286907	202	34142											
CEACAM6	4680	broad.mit.edu	37	chr19	42260722	42260722	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caacaagctaccccagggccCgcatacagtggtcgagagac	12	4	11	14	2	0	1	0	0	0	1	1	3	0	1	3	2	4	2	3	2	4	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:42260722C>T	uc002orm.2	+	2	428	c.279C>T	c.(277-279)CCC>CCT	p.P93P		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	93	Ig-like V-type.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		CCCCAGGGCCCGCATACAGTG	0.458													72	103					0	0	0	0	T	42260722	T	T	42260722	2	4	181	1	0	0	0	0	0	0	0	1	3211	639	23	1		1	CEACAM6	19	42260722	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	1418646	42260722	16868261	203	34143											
PSG1	5669	broad.mit.edu	37	chr19	43382154	43382154	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaggatcctgcgtcctccCgggtgacattctggatcagc	6	11	12	12	2	2	1	1	1	1	0	5	3	5	3	3	3	2	1	3	3	1	2	rs142473373		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:43382154C>T	uc002ovb.2	-	2	479	c.341G>A	c.(340-342)CGG>CAG	p.R114Q	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.R114Q|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.R114Q|PSG1_uc010eio.1_Missense_Mutation_p.R114Q|PSG1_uc002oux.1_Missense_Mutation_p.R43Q|PSG1_uc002ouy.1_Missense_Mutation_p.R114Q|PSG1_uc002ouz.1_Missense_Mutation_p.R114Q|PSG1_uc002ova.1_Missense_Mutation_p.R114Q|PSG1_uc002ovc.2_Missense_Mutation_p.R114Q|PSG1_uc002ovd.1_Missense_Mutation_p.R114Q	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	114	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TGCGTCCTCCCGGGTGACATT	0.453													149	136					0	0	0	0	T	43382154	T	T	43382154	3	4	181	1	0	0	0	0	1	0	0	0	12715	652	23	1	991	1	PSG1	19	43382154	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	1121432	43382154	15746829	204	34144											
HIF3A	64344	broad.mit.edu	37	chr19	46832529	46832529	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggatgatgacttccagctCaacgccagcgagcagctacc	11	7	10	13	2	1	2	1	2	0	0	2	4	2	3	3	1	6	3	3	1	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:46832529C>G	uc002peh.2	+	12	1535	c.1506C>G	c.(1504-1506)CTC>CTG	p.L502L	HIF3A_uc002peg.3_Silent_p.L502L|HIF3A_uc002pei.3_Silent_p.L446L|HIF3A_uc002pej.1_Intron|HIF3A_uc002pek.2_Silent_p.L446L|HIF3A_uc010xxy.1_Silent_p.L433L|HIF3A_uc002pel.2_Silent_p.L500L|HIF3A_uc010xxz.1_Silent_p.L451L	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	502	NTAD.|ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		ACTTCCAGCTCAACGCCAGCG	0.587													17	81					0	0	0	0	G	46832529	G	G	46832529	2	3	181	1	0	0	0	0	0	0	0	1	7144	813	29	2		2	HIF3A	19	46832529	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	3450375	46832529	12296454	205	34145											
NUCB1	4924	broad.mit.edu	37	chr19	49422529	49422529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaggagtttggggacaccGgggagggctgggaggtgaga	9	5	23	4	1	0	1	0	1	0	1	0	7	0	6	1	9	0	2	1	9	1	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:49422529G>A	uc002plb.3	+	10	1060	c.988G>A	c.(988-990)GGG>AGG	p.G330R	NUCB1_uc002pla.2_Missense_Mutation_p.G330R|NUCB1_uc002plc.2_Missense_Mutation_p.G330R|NUCB1_uc002pld.2_5'UTR	NM_006184	NP_006175	Q02818	NUCB1_HUMAN	nucleobindin 1 precursor	330						ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding				0		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		TGGGGACACCGGGGAGGGCTG	0.577													6	37					0	0	0	0	A	49422529	A	A	49422529	3	1	181	1	0	0	0	0	1	0	0	0	10772	1116	39	1	1022	1	NUCB1	19	49422529	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	2590000	49422529	9706454	206	34146											
CCDC155	147872	broad.mit.edu	37	chr19	49910549	49910549	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaagagacaccatcctctCtgaggtaaggggccccggga	11	5	12	13	1	1	2	0	1	1	1	3	4	2	3	5	4	0	1	5	4	2	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:49910549C>T	uc002pnm.1	+	11	1103	c.929C>T	c.(928-930)TCT>TTT	p.S310F	CCDC155_uc010emx.1_Missense_Mutation_p.S283F	NM_144688	NP_653289	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	310	Potential.					integral to membrane	calcium ion binding			ovary(1)|central_nervous_system(1)	2						ACCATCCTCTCTGAGGTAAGG	0.572													3	21					0	0	0	0	T	49910549	T	T	49910549	3	4	181	1	0	0	0	0	1	0	0	0	2801	913	32	2	967	2	CCDC155	19	49910549	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	488020	49910549	9218434	207	34147											
NAPSA	9476	broad.mit.edu	37	chr19	50861932	50861932	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcggtcgaagacggccacatAcgtccccaagaagacgtcac	12	4	11	14	5	1	3	1	0	0	3	3	4	2	3	3	2	1	0	3	2	4	1	rs138846093		TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:50861932A>T	uc002prx.2	-	9	1194	c.1141T>A	c.(1141-1143)TAT>AAT	p.Y381N	NR1H2_uc002prv.3_Intron	NM_004851	NP_004842	O96009	NAPSA_HUMAN	napsin A preproprotein	381					proteolysis	extracellular region	aspartic-type endopeptidase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		ACGGCCACATACGTCCCCAAG	0.677													4	13					0	0	0	0	T	50861932	T	T	50861932	3	4	181	1	0	0	0	0	1	0	0	0	10219	391	14	5	125	5	NAPSA	19	50861932	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08	951383	50861932	8267051	208	34148											
ZNF667	63934	broad.mit.edu	37	chr19	56953259	56953259	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaataagggttgaaagccGcctgaagaacttgtcacatt	14	9	10	8	1	1	4	1	2	0	2	1	4	1	4	2	1	2	1	2	1	5	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr19:56953259G>T	uc002qnd.2	-	5	1267	c.1105C>A	c.(1105-1107)CGG>AGG	p.R369R	ZNF667_uc010etl.2_Silent_p.R151R|ZNF667_uc002qne.2_Silent_p.R369R|ZNF667_uc010etm.2_Silent_p.R312R	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	369	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GTTGAAAGCCGCCTGAAGAAC	0.378													24	24					7.92952e-12	8.65567e-12	1	0	T	56953259	T	T	56953259	2	4	181	1	0	0	0	0	0	0	0	1	18141	1086	38	3		3	ZNF667	19	56953259	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	6091327	56953259	2175724	209	34149											
COMMD7	149951	broad.mit.edu	37	chr20	31291246	31291246	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcaggaagctgtagaactGaggcaaggttaattctgggg	11	9	16	5	0	1	2	0	1	1	1	1	3	1	3	0	5	3	5	0	5	5	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr20:31291246G>C	uc002wya.3	-	9	1158	c.541C>G	c.(541-543)CAG>GAG	p.Q181E	COMMD7_uc010ged.2_Missense_Mutation_p.Q180E|COMMD7_uc002wyb.2_3'UTR	NM_053041	NP_444269	Q86VX2	COMD7_HUMAN	COMM domain containing 7 isoform 1	181	COMM.				negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|tumor necrosis factor-mediated signaling pathway		NF-kappaB binding			breast(1)	1						CTGTAGAACTGAGGCAAGGTT	0.478													7	46					0	0	0	0	C	31291246	C	C	31291246	3	2	181	1	0	0	0	0	1	0	0	0	3736	1299	45	2	65	2	COMMD7	20	31291246	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08		31291246	31734274	210	34150											
C20orf71	128861	broad.mit.edu	37	chr20	31813054	31813054	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgtggccatcctcactgaGtaagaccccagctgcccctc	8	8	8	17	0	1	2	1	1	0	1	3	2	2	2	6	1	2	2	6	1	1	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr20:31813054G>T	uc002wyr.2	+	4	744	c.536_splice	c.e4+1	p.E179_splice	C20orf71_uc002wys.2_Splice_Site_p.E143_splice	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium							extracellular region	lipid binding			ovary(1)|skin(1)	2						TCCTCACTGAGTAAGACCCCA	0.547													9	84					0.00448238	0.00457448	1	0	T	31813054	T	T	31813054	5	4	181	1	0	0	0	0	0	0	1	0	2127	1043	36	4	551	4	C20orf71	20	31813054	Splice_Site	SNP	G	TCGA-CV-5970-01A-11D-1683-08	521808	31813054	31212466	211	34151											
GSS	2937	broad.mit.edu	37	chr20	33529522	33529522	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcacacccttacttgggtGagccgtagagctcccaggct	7	11	10	13	1	1	2	1	1	0	1	2	2	2	2	3	2	3	3	3	2	2	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr20:33529522G>A	uc002xbg.2	-	6	682	c.602C>T	c.(601-603)TCA>TTA	p.S201L	GSS_uc010zun.1_Missense_Mutation_p.S73L|GSS_uc010zuo.1_Intron|GSS_uc010zup.1_Missense_Mutation_p.S132L|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_Intron	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	201					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	TTACTTGGGTGAGCCGTAGAG	0.483													11	63					0	0	0	0	A	33529522	A	A	33529522	3	1	181	1	0	0	0	0	1	0	0	0	6868	1294	45	2	854	2	GSS	20	33529522	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	1716468	33529522	29495998	212	34152											
SEMG1	6406	broad.mit.edu	37	chr20	43836743	43836743	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatataacaagaatcaacacCagacaaaaaatctcaatcaa	23	7	2	9	0	3	2	3	0	1	2	4	2	3	2	1	0	2	0	1	0	11	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr20:43836743C>G	uc002xni.2	+	2	862	c.805C>G	c.(805-807)CAG>GAG	p.Q269E	SEMG1_uc002xnj.2_Missense_Mutation_p.Q269E|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.Q269E	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	269	42 AA repeat 2.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				GAATCAACACCAGACAAAAAA	0.398													9	63					0	0	0	0	G	43836743	G	G	43836743	3	3	181	1	0	0	0	0	1	0	0	0	14109	595	21	4	811	4	SEMG1	20	43836743	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	10307221	43836743	19188777	213	34153											
BMP7	655	broad.mit.edu	37	chr20	55777625	55777625	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatgtcaaacaccagccaGccctcctccgaggcccagag	10	5	10	16	1	1	2	1	1	0	1	3	3	3	2	6	1	3	0	6	1	1	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr20:55777625G>A	uc010gip.1	-	3	1195	c.666C>T	c.(664-666)GGC>GGT	p.G222G	BMP7_uc010giq.1_Silent_p.G222G|BMP7_uc002xyc.2_Silent_p.G222G	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor	222					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			ACACCAGCCAGCCCTCCTCCG	0.627													9	35					0	0	0	0	A	55777625	A	A	55777625	2	1	181	1	0	0	0	0	0	0	0	1	1468	958	34	4		4	BMP7	20	55777625	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	11940882	55777625	7247895	214	34154											
DSCAM	1826	broad.mit.edu	37	chr21	41416162	41416162	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggctggcatagcggtttctCgctgtgggcccagccttggc	3	11	15	12	2	1	0	0	0	1	0	2	0	1	0	2	5	2	4	2	5	1	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr21:41416162C>T	uc002yyq.1	-	31	5678	c.5226G>A	c.(5224-5226)GCG>GCA	p.A1742A	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1742	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGCGGTTTCTCGCTGTGGGCC	0.602													8	24					0	0	0	0	T	41416162	T	T	41416162	2	4	181	1	0	0	0	0	0	0	0	1	4790	871	31	1		1	DSCAM	21	41416162	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08		41416162	6713733	215	34155											
TMPRSS2	7113	broad.mit.edu	37	chr21	42861456	42861456	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacttccagagtaggccagcGgccagcgcagctcccacgag	10	4	12	15	3	0	1	0	0	0	1	2	2	2	1	4	2	4	3	4	2	2	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr21:42861456G>A	uc002yzj.2	-	4	437	c.303C>T	c.(301-303)GCC>GCT	p.A101A	TMPRSS2_uc010gor.2_Silent_p.A138A|TMPRSS2_uc010gos.1_Silent_p.A101A	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	101	Helical; Signal-anchor for type II membrane protein; (Potential).				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				GTAGGCCAGCGGCCAGCGCAG	0.592			T	ERG|ETV1|ETV4|ETV5	prostate 								14	30					0	0	0	0	A	42861456	A	A	42861456	2	1	181	1	0	0	0	0	0	0	0	1	16313	1103	39	1		1	TMPRSS2	21	42861456	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	1445294	42861456	5268439	216	34156											
ADARB1	104	broad.mit.edu	37	chr21	46596022	46596022	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcaaaactccatgctgctGagaaggccttgaggtctttc	10	10	11	10	0	1	2	0	2	1	1	3	3	2	2	2	3	3	3	2	3	3	2			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr21:46596022G>A	uc002zgy.2	+	4	841	c.406G>A	c.(406-408)GAG>AAG	p.E136K	ADARB1_uc002zgr.2_Missense_Mutation_p.E136K|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Missense_Mutation_p.E136K|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Missense_Mutation_p.E136K|ADARB1_uc010gpx.2_Intron|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA|ADARB1_uc011afo.1_Missense_Mutation_p.E185K	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	136	DRBM 1.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		CCATGCTGCTGAGAAGGCCTT	0.542													9	43					0	0	0	0	A	46596022	A	A	46596022	3	1	181	1	0	0	0	0	1	0	0	0	282	1291	45	2	412	2	ADARB1	21	46596022	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	3734566	46596022	1533873	217	34157											
PRAME	23532	broad.mit.edu	37	chr22	22892745	22892745	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccgtaaatccagcacttgaAgtttccacctcctgtgggga	9	11	9	12	1	0	1	0	1	0	0	4	2	4	2	5	2	1	3	5	2	3	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr22:22892745A>C	uc002zwf.2	-	4	512	c.356T>G	c.(355-357)CTT>CGT	p.L119R	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Missense_Mutation_p.L103R|PRAME_uc010gtr.2_Missense_Mutation_p.L119R|PRAME_uc002zwg.2_Missense_Mutation_p.L119R|PRAME_uc002zwh.2_Missense_Mutation_p.L119R|PRAME_uc002zwi.2_Missense_Mutation_p.L119R|PRAME_uc002zwj.2_Missense_Mutation_p.L119R|PRAME_uc002zwk.2_Missense_Mutation_p.L119R	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	119					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		CAGCACTTGAAGTTTCCACCT	0.438													8	60					0	0	0	0	C	22892745	C	C	22892745	3	2	181	1	0	0	0	0	1	0	0	0	12484	72	3	5	1181	5	PRAME	22	22892745	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08		22892745	28411821	218	34158											
HSCB	150274	broad.mit.edu	37	chr22	29139936	29139936	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagcaactgcagcgtcttgtCcacccagatttcttcagcca	9	10	7	15	1	3	1	1	0	2	1	4	1	4	1	3	0	5	2	3	0	1	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr22:29139936C>T	uc003aea.2	+	2	344	c.303C>T	c.(301-303)GTC>GTT	p.V101V	CHEK2_uc003adt.1_5'Flank|CHEK2_uc003adu.1_5'Flank|CHEK2_uc003adv.1_5'Flank|CHEK2_uc003adw.1_5'Flank|CHEK2_uc003adx.1_5'Flank|CHEK2_uc003ady.1_5'Flank|CHEK2_uc003adz.1_5'Flank	NM_172002	NP_741999	Q8IWL3	HSC20_HUMAN	J-type co-chaperone HSC20 precursor	101	J.				iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)	1						AGCGTCTTGTCCACCCAGATT	0.483													14	91					0	0	0	0	T	29139936	T	T	29139936	2	4	181	1	0	0	0	0	0	0	0	1	7413	842	30	2		2	HSCB	22	29139936	Silent	SNP	C	TCGA-CV-5970-01A-11D-1683-08	6247191	29139936	22164630	219	34159											
RFPL2	10739	broad.mit.edu	37	chr22	32586995	32586995	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccactcgctgtaacttgcGgtctacgaagaggaaagtca	11	8	10	12	3	2	1	1	0	1	1	3	3	2	2	2	2	3	2	2	2	4	3			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr22:32586995G>A	uc003amg.3	-	5	1837	c.901C>T	c.(901-903)CGC>TGC	p.R301C	RFPL2_uc003ame.3_Missense_Mutation_p.R240C|RFPL2_uc003amf.3_Missense_Mutation_p.R211C|RFPL2_uc003amh.3_Missense_Mutation_p.R211C	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	301	B30.2/SPRY.						zinc ion binding			skin(1)	1						TGTAACTTGCGGTCTACGAAG	0.517													12	38					0	0	0	0	A	32586995	A	A	32586995	3	1	181	1	0	0	0	0	1	0	0	0	13319	1116	39	1	239	1	RFPL2	22	32586995	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	3447059	32586995	18717571	220	34160											
TAB1	10454	broad.mit.edu	37	chr22	39826084	39826084	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagcagcagctccagctctGacggaggcctcttccgctcc	7	7	11	16	2	2	2	0	1	2	1	5	3	5	3	4	2	4	5	4	2	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr22:39826084G>A	uc003axt.2	+	11	1421	c.1372G>A	c.(1372-1374)GAC>AAC	p.D458N	TAB1_uc003axr.2_Missense_Mutation_p.D534N|TAB1_uc011aok.1_Missense_Mutation_p.D292N|TAB1_uc003axu.1_Intron	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	458					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						CTCCAGCTCTGACGGAGGCCT	0.627													7	86					0	0	0	0	A	39826084	A	A	39826084	3	1	181	1	0	0	0	0	1	0	0	0	15561	1290	45	2	1414	2	TAB1	22	39826084	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	7239089	39826084	11478482	221	34161											
EFCAB6	64800	broad.mit.edu	37	chr22	44079707	44079707	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taactttgtgatgatgttttCcttgtgagattcatttctag	8	20	8	5	0	2	3	1	3	1	1	3	4	3	3	1	0	1	1	1	0	2	8			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr22:44079707C>A	uc003bdy.1	-	12	1386	c.1171G>T	c.(1171-1173)GAA>TAA	p.E391*	EFCAB6_uc003bdz.1_Nonsense_Mutation_p.E239*|EFCAB6_uc010gzi.1_Nonsense_Mutation_p.E239*|EFCAB6_uc010gzk.1_Intron|EFCAB6_uc011aqa.1_Intron|EFCAB6_uc003bea.1_Nonsense_Mutation_p.E388*	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				ATGATGTTTTCCTTGTGAGAT	0.343													21	91					1.28384e-07	1.35668e-07	1	0	A	44079707	A	A	44079707	4	1	181	1	0	0	0	0	0	1	0	0	4961	864	30	2	3418	2	EFCAB6	22	44079707	Nonsense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	4253623	44079707	7224859	222	34162											
TUBGCP6	85378	broad.mit.edu	37	chr22	50660299	50660299	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctcagggcccggagacGtgacctgaaacacaggtgac	10	5	15	11	2	1	4	1	3	0	1	1	5	1	4	2	4	2	1	2	4	1	0			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr22:50660299G>A	uc003bkb.1	-	16	3001	c.2489C>T	c.(2488-2490)ACG>ATG	p.T830M	TUBGCP6_uc003bka.1_Translation_Start_Site|TUBGCP6_uc010har.1_Missense_Mutation_p.T822M|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_Missense_Mutation_p.T26M	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	830					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCCCGGAGACGTGACCTGAAA	0.622													6	32					0	0	0	0	A	50660299	A	A	50660299	3	1	181	1	0	0	0	0	1	0	0	0	16838	1145	40	1	3010	1	TUBGCP6	22	50660299	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08	6580592	50660299	644267	223	34163											
SBF1	6305	broad.mit.edu	37	chr22	50898068	50898068	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggcgttgtcctggacactCtggggcacgatcagcagccc	7	7	14	13	2	2	0	1	0	1	0	3	2	3	1	2	4	2	3	2	4	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chr22:50898068C>G	uc003blh.2	-	27	3714	c.3519G>C	c.(3517-3519)CAG>CAC	p.Q1173H	SBF1_uc011arx.1_Missense_Mutation_p.Q837H	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1173	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CCTGGACACTCTGGGGCACGA	0.701													3	33					0	0	0	0	G	50898068	G	G	50898068	3	3	181	1	0	0	0	0	1	0	0	0	13923	912	32	2	2222	2	SBF1	22	50898068	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	237769	50898068	406498	224	34164											
SHROOM2	357	broad.mit.edu	37	chrX	9863269	9863269	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accacagccccctctgtgctGacagccttgggcaggagcca	8	6	11	16	0	1	1	0	1	1	0	1	2	1	2	5	2	4	2	5	2	0	1			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chrX:9863269G>A	uc004csu.1	+	4	1411	c.1321G>A	c.(1321-1323)GAC>AAC	p.D441N		NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	441					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CCTCTGTGCTGACAGCCTTGG	0.652													18	16					0	0	0	0	A	9863269	A	A	9863269	3	1	181	1	0	0	0	0	1	0	0	0	14359	1290	45	2	1335	2	SHROOM2	23	9863269	Missense_Mutation	SNP	G	TCGA-CV-5970-01A-11D-1683-08		9863269	145407291	225	34165											
SCML2	10389	broad.mit.edu	37	chrX	18283829	18283829	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcctgacctgctgtgttggtAatattagagtagttttctgt	7	18	10	6	0	1	2	0	1	1	1	2	2	2	2	2	1	1	5	2	1	4	7			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chrX:18283829A>G	uc004cyl.2	-	8	981	c.824T>C	c.(823-825)TTA>TCA	p.L275S	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.L275S|SCML2_uc011miz.1_Missense_Mutation_p.L209S|SCML2_uc010nfc.2_Missense_Mutation_p.L11S	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	275					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					CTGTGTTGGTAATATTAGAGT	0.418													13	27					0	0	0	0	G	18283829	G	G	18283829	3	3	181	1	0	0	0	0	1	0	0	0	13975	372	13	5	1310	5	SCML2	23	18283829	Missense_Mutation	SNP	A	TCGA-CV-5970-01A-11D-1683-08	8420560	18283829	136986731	226	34166											
CXorf58	254158	broad.mit.edu	37	chrX	23928433	23928433	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggaaaatgaatcgttcctCaaatgtaccacgtaaaggta	16	9	9	7	2	1	1	1	1	0	0	3	2	2	2	2	2	1	4	2	2	8	4			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chrX:23928433C>T	uc004daz.1	+	2	358	c.14C>T	c.(13-15)TCA>TTA	p.S5L	APOO_uc004dax.2_5'Flank|APOO_uc004day.3_5'Flank|CXorf58_uc011mju.1_Missense_Mutation_p.S5L	NM_152761	NP_689974	Q96LI9	CX058_HUMAN	hypothetical protein LOC254158	5											0						AATCGTTCCTCAAATGTACCA	0.348													7	10					0	0	0	0	T	23928433	T	T	23928433	3	4	181	1	0	0	0	0	1	0	0	0	4131	838	29	2	16	2	CXorf58	23	23928433	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	5644604	23928433	131342127	227	34167											
BRS3	680	broad.mit.edu	37	chrX	135572633	135572633	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tactgaggaacaaagccatgCccgtaagcaggtatgtatta	14	9	10	8	1	0	1	0	1	0	0	0	2	0	2	2	2	5	4	2	2	7	5			TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chrX:135572633C>T	uc004ezv.1	+	2	925	c.776C>T	c.(775-777)GCC>GTC	p.A259V		NM_001727	NP_001718	P32247	BRS3_HUMAN	bombesin-like receptor 3	259	Cytoplasmic (Potential).				adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					CAAAGCCATGCCCGTAAGCAG	0.388													3	42					0	0	0	0	T	135572633	T	T	135572633	3	4	181	1	0	0	0	0	1	0	0	0	1527	739	26	4	782	4	BRS3	23	135572633	Missense_Mutation	SNP	C	TCGA-CV-5970-01A-11D-1683-08	111644200	135572633	19697927	228	34168											
AFF2	2334	broad.mit.edu	37	chrX	147924495	147924495	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tattattccttataggaatcGcagcatctgaccccaggatt	11	13	7	10	1	1	1	0	1	1	0	3	3	2	3	3	2	1	2	3	2	5	6	rs149177157	byFrequency	TCGA-CV-5970-01A-11D-1683-08	TCGA-CV-5970-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	a52dc15f-d06d-46ed-a73e-aa004a2a736a	f32b53d5-28b2-4d09-bff7-af5bca3d3e33	g.chrX:147924495G>A	uc004fcp.2	+	6	1658	c.1179G>A	c.(1177-1179)TCG>TCA	p.S393S	AFF2_uc004fco.2_Silent_p.S360S|AFF2_uc004fcq.2_Silent_p.S389S|AFF2_uc004fcr.2_Silent_p.S360S|AFF2_uc011mxb.1_Silent_p.S364S|AFF2_uc004fcs.2_Silent_p.S360S|AFF2_uc011mxc.1_Silent_p.S34S	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	393					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TATAGGAATCGCAGCATCTGA	0.333													41	23					0	0	0	0	A	147924495	A	A	147924495	2	1	181	1	0	0	0	0	0	0	0	1	357	1074	38	1		1	AFF2	23	147924495	Silent	SNP	G	TCGA-CV-5970-01A-11D-1683-08	12351862	147924495	7346065	229	34169											
CELSR2	1952	broad.mit.edu	37	chr1	109794178	109794178	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgtctctggcttggtgacaGtacaggtcctggatatcaac	9	12	11	9	0	2	1	1	1	1	0	4	2	3	2	1	4	2	2	1	4	3	3			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr1:109794178G>A	uc001dxa.3	+	1	1538	c.1477G>A	c.(1477-1479)GTA>ATA	p.V493I		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	493	Cadherin 3.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTTGGTGACAGTACAGGTCCT	0.567													4	183					0	0	0	0	A	109794178	A	A	109794178	3	1	182	1	0	0	0	0	1	0	0	0	3237	1029	36	4	1479	4	CELSR2	1	109794178	Missense_Mutation	SNP	G	TCGA-CV-5971-01A-11D-1683-08		109794178	139456443	1	34170											
FLG	2312	broad.mit.edu	37	chr1	152286334	152286334	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagtgcccatgactggctCtgtcttcatcatgggacctg	7	11	11	12	0	4	2	2	1	2	1	4	3	4	3	2	2	1	1	2	2	0	1			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr1:152286334C>T	uc001ezu.1	-	3	1064	c.1028G>A	c.(1027-1029)AGA>AAA	p.R343K	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	343	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGACTGGCTCTGTCTTCATC	0.562									Ichthyosis				10	238					0	0	0	0	T	152286334	T	T	152286334	3	4	182	1	0	0	0	0	1	0	0	0	5954	913	32	2	11161	2	FLG	1	152286334	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08	42492156	152286334	96964287	2	34171											
CFHR2	3080	broad.mit.edu	37	chr1	196918742	196918742	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttggactcgcataacgtgCgcagaagaaggatggtcacc	11	9	12	9	3	1	2	1	0	0	2	2	4	1	4	1	3	2	2	1	3	3	3			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr1:196918742C>T	uc001gtq.1	+	2	293	c.216C>T	c.(214-216)TGC>TGT	p.C72C	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	72	Sushi 1.					extracellular region				skin(2)|ovary(1)	3						GCATAACGTGCGCAGAAGAAG	0.408													4	40					0	0	0	0	T	196918742	T	T	196918742	2	4	182	1	0	0	0	0	0	0	0	1	3300	776	27	1		1	CFHR2	1	196918742	Silent	SNP	C	TCGA-CV-5971-01A-11D-1683-08	44632408	196918742	52331879	3	34172											
ATAD2B	54454	broad.mit.edu	37	chr2	24046267	24046267	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaagacatcacagcacgttgGgaagcaggcacgatattctg	13	7	12	9	2	2	1	1	0	1	1	2	4	2	2	0	2	2	4	0	2	3	3			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr2:24046267G>A	uc002rek.3	-	16	2286	c.1992C>T	c.(1990-1992)TCC>TCT	p.S664S	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rej.3_5'UTR	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	664							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCACGTTGGGAAGCAGGCA	0.453													3	28					0	0	0	0	A	24046267	A	A	24046267	2	1	182	1	0	0	0	0	0	0	0	1	1074	1219	43	4		4	ATAD2B	2	24046267	Silent	SNP	G	TCGA-CV-5971-01A-11D-1683-08		24046267	219153106	4	34173											
C2orf16	84226	broad.mit.edu	37	chr2	27804893	27804893	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggagccgtcacagtctcttGgagaggagccatcgcagtcc	9	7	13	12	2	2	1	1	0	1	1	5	4	3	3	3	3	2	1	3	3	0	1			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr2:27804893G>A	uc002rkz.3	+	1	5505	c.5454G>A	c.(5452-5454)TTG>TTA	p.L1818L	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1818	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					ACAGTCTCTTGGAGAGGAGCC	0.537													6	104					0	0	0	0	A	27804893	A	A	27804893	2	1	182	1	0	0	0	0	0	0	0	1	2167	1339	47	4		4	C2orf16	2	27804893	Silent	SNP	G	TCGA-CV-5971-01A-11D-1683-08	3758626	27804893	215394480	5	34174											
RGPD4	285190	broad.mit.edu	37	chr2	108488636	108488636	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaattatgataataagcaAgttcgtatagtgatgagaag	17	11	10	3	1	0	4	0	3	0	2	1	5	0	4	0	0	1	3	0	0	8	6			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr2:108488636A>T	uc010ywk.1	+	20	4258	c.4176A>T	c.(4174-4176)CAA>CAT	p.Q1392H	RGPD4_uc002tdu.2_Missense_Mutation_p.Q579H|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1392	RanBD1 2.				intracellular transport		binding			skin(2)	2						ATAATAAGCAAGTTCGTATAG	0.363													6	246					0	0	0	0	T	108488636	T	T	108488636	3	4	182	1	0	0	0	0	1	0	0	0	13353	69	3	5	4254	5	RGPD4	2	108488636	Missense_Mutation	SNP	A	TCGA-CV-5971-01A-11D-1683-08	80683743	108488636	134710737	6	34175											
CRYGA	1418	broad.mit.edu	37	chr2	209025578	209025578	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccgactttggcatctgcacCcccccagtcgtggtaccttc	5	10	9	17	2	1	0	0	0	1	0	3	1	1	0	5	2	2	3	5	2	1	3			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr2:209025578C>T	uc002vcq.3	-	3	492	c.475G>A	c.(475-477)GGT>AGT	p.G159S		NM_014617	NP_055432	P11844	CRGA_HUMAN	crystallin, gamma A	159	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens				0				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		GCATCTGCACCCCCCCAGTCG	0.537													3	87					0	0	0	0	T	209025578	T	T	209025578	3	4	182	1	0	0	0	0	1	0	0	0	3929	623	22	4	53	4	CRYGA	2	209025578	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08	100536942	209025578	34173795	7	34176											
CCR1	1230	broad.mit.edu	37	chr3	46244880	46244880	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caactgccgcaggtacttccGgaacctctcaccaacgaagg	11	6	9	15	3	1	0	1	0	1	0	3	2	2	1	4	3	5	2	4	3	5	2			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr3:46244880G>A	uc003cph.1	-	2	996	c.925C>T	c.(925-927)CGG>TGG	p.R309W	CCR3_uc003cpg.1_Intron	NM_001295	NP_001286	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	309	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			skin(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		AGGTACTTCCGGAACCTCTCA	0.587													3	25					0	0	0	0	A	46244880	A	A	46244880	3	1	182	1	0	0	0	0	1	0	0	0	2954	1115	39	1	146	1	CCR1	3	46244880	Missense_Mutation	SNP	G	TCGA-CV-5971-01A-11D-1683-08		46244880	151777550	8	34177											
C3orf38	285237	broad.mit.edu	37	chr3	88199220	88199220	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggatggagatgtcgggactCagcttttcagagatggaggg	9	9	18	5	1	2	2	2	0	0	2	3	7	2	5	0	5	1	1	0	5	0	2			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr3:88199220C>G	uc003dqw.2	+	2	329	c.18C>G	c.(16-18)CTC>CTG	p.L6L	CGGBP1_uc003dqu.2_5'Flank	NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	6					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TGTCGGGACTCAGCTTTTCAG	0.617													3	24					0	0	0	0	G	88199220	G	G	88199220	2	3	182	1	0	0	0	0	0	0	0	1	2238	813	29	2		2	C3orf38	3	88199220	Silent	SNP	C	TCGA-CV-5971-01A-11D-1683-08	41954340	88199220	109823210	9	34178											
MAP1B	4131	broad.mit.edu	37	chr5	71492944	71492944	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtgaaaaggtcagcccatcGaagagcccgtccctgagtcc	11	6	11	13	2	1	3	1	2	0	1	4	4	3	3	4	1	2	0	4	1	3	0			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr5:71492944G>A	uc003kbw.3	+	5	4003	c.3762G>A	c.(3760-3762)TCG>TCA	p.S1254S	MAP1B_uc010iyw.1_Silent_p.S1271S|MAP1B_uc010iyx.1_Silent_p.S1128S|MAP1B_uc010iyy.1_Silent_p.S1128S	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1254						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TCAGCCCATCGAAGAGCCCGT	0.493													5	44					0	0	0	0	A	71492944	A	A	71492944	2	1	182	1	0	0	0	0	0	0	0	1	9281	1045	37	1		1	MAP1B	5	71492944	Silent	SNP	G	TCGA-CV-5971-01A-11D-1683-08		71492944	109422316	10	34179											
AFF4	27125	broad.mit.edu	37	chr5	132232314	132232314	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacaggagtcctattgctctCggggtacttaggagtttgtg	8	13	13	7	1	1	0	0	0	1	0	3	2	2	2	1	4	3	3	1	4	4	5			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr5:132232314C>T	uc003kyd.2	-	11	2416	c.2008G>A	c.(2008-2010)GAG>AAG	p.E670K	AFF4_uc011cxk.1_Missense_Mutation_p.E348K|AFF4_uc003kye.1_Missense_Mutation_p.E670K	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	670					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTATTGCTCTCGGGGTACTTA	0.443													4	55					0	0	0	0	T	132232314	T	T	132232314	3	4	182	1	0	0	0	0	1	0	0	0	359	893	31	1	1527	1	AFF4	5	132232314	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08	60739370	132232314	48682946	11	34180											
PCDHGA3	56112	broad.mit.edu	37	chr5	140723793	140723793	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctggcggagcgcggagtcCgcatcgtctccagaggtagg	7	6	17	11	5	1	1	0	0	1	1	4	3	2	3	2	5	2	3	2	5	1	1			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr5:140723793C>T	uc003ljm.1	+	1	193	c.193C>T	c.(193-195)CGC>TGC	p.R65C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.R65C	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	65	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGAGTCCGCATCGTCTC	0.617											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	136					0	0	0	0	T	140723793	T	T	140723793	3	4	182	1	0	0	0	0	1	0	0	0	11609	652	23	1	195	1	PCDHGA3	5	140723793	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08	8491479	140723793	40191467	12	34181											
ASF1A	25842	broad.mit.edu	37	chr6	119226832	119226832	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tctaggctgatgcacctaatCcaggactcattccagatgca	11	10	8	12	0	2	2	1	1	1	1	4	3	4	3	3	2	2	3	3	2	2	3			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr6:119226832C>G	uc011ebn.1	+	3	578	c.241C>G	c.(241-243)CCA>GCA	p.P81A		NM_014034	NP_054753	Q9Y294	ASF1A_HUMAN	ASF1 anti-silencing function 1 homolog A	81	Interaction with histone H3, CHAF1B, and HIRA.				chromatin modification|DNA repair|loss of chromatin silencing|nucleosome assembly|transcription, DNA-dependent	chromatin remodeling complex	chromatin binding|histone binding				0		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0633)|OV - Ovarian serous cystadenocarcinoma(136;0.188)		TGCACCTAATCCAGGACTCAT	0.393													3	116					0	0	0	0	G	119226832	G	G	119226832	3	3	182	1	0	0	0	0	1	0	0	0	1039	855	30	2	138	2	ASF1A	6	119226832	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08		119226832	51888235	13	34182											
PCLO	27445	broad.mit.edu	37	chr7	82581315	82581315	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttcattcccccaatccctCtataaccatatggccctgat	9	12	4	16	0	2	1	1	1	1	0	4	1	4	1	5	1	1	1	5	1	4	5			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr7:82581315C>G	uc003uhx.2	-	5	9243	c.8954G>C	c.(8953-8955)AGA>ACA	p.R2985T	PCLO_uc003uhv.2_Missense_Mutation_p.R2985T|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2916					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CCCAATCCCTCTATAACCATA	0.423													7	173					0	0	0	0	G	82581315	G	G	82581315	3	3	182	1	0	0	0	0	1	0	0	0	11637	913	32	2	6575	2	PCLO	7	82581315	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08		82581315	76557348	14	34183											
TAS2R5	54429	broad.mit.edu	37	chr7	141490605	141490605	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccaaattggcttaacattCtatcatcctccccaaggaaa	13	11	5	12	0	2	0	1	0	1	0	5	1	5	1	4	2	1	1	4	2	5	4			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr7:141490605C>T	uc003vwr.1	+	1	589	c.444C>T	c.(442-444)TTC>TTT	p.F148F		NM_018980	NP_061853	Q9NYW4	TA2R5_HUMAN	taste receptor T2R5	148	Helical; Name=4; (Potential).				chemosensory behavior|sensory perception of taste		taste receptor activity				0	Melanoma(164;0.0171)					GCTTAACATTCTATCATCCTC	0.433													4	24					0	0	0	0	T	141490605	T	T	141490605	2	4	182	1	0	0	0	0	0	0	0	1	15649	912	32	2		2	TAS2R5	7	141490605	Silent	SNP	C	TCGA-CV-5971-01A-11D-1683-08	58909290	141490605	17648058	15	34184											
CPA6	57094	broad.mit.edu	37	chr8	68423859	68423859	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtgcaagctgcttcccttctCcagtgttttctgaagatctt	6	16	8	11	0	3	2	0	1	3	1	5	2	4	2	2	0	3	4	2	0	2	5			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr8:68423859C>G	uc003xxq.3	-	4	605	c.349G>C	c.(349-351)GAG>CAG	p.E117Q	CPA6_uc003xxr.3_5'UTR|CPA6_uc003xxs.2_Missense_Mutation_p.E117Q	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	117					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			CTTCCCTTCTCCAGTGTTTTC	0.388													6	198					0	0	0	0	G	68423859	G	G	68423859	3	3	182	1	0	0	0	0	1	0	0	0	3809	864	30	2	996	2	CPA6	8	68423859	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08		68423859	77940163	16	34185											
FAM189A2	9413	broad.mit.edu	37	chr9	71992331	71992331	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaatgccctgaccaccaccGtctgcttggtggccgctgcc	5	9	11	16	2	1	2	0	2	1	0	1	2	1	2	6	2	3	2	6	2	1	1			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr9:71992331G>A	uc010mon.1	+	5	402	c.298G>A	c.(298-300)GTC>ATC	p.V100I	FAM189A2_uc004ahg.2_Missense_Mutation_p.V100I|FAM189A2_uc010moo.1_5'UTR	NM_001127608	NP_001121080	Q15884	F1892_HUMAN	chromosome 9 open reading frame 61 precursor	100	Helical; (Potential).					integral to membrane					0						GACCACCACCGTCTGCTTGGT	0.532													7	55					0	0	0	0	A	71992331	A	A	71992331	3	1	182	1	0	0	0	0	1	0	0	0	5544	1145	40	1	312	1	FAM189A2	9	71992331	Missense_Mutation	SNP	G	TCGA-CV-5971-01A-11D-1683-08		71992331	69221100	17	34186											
TRPM6	140803	broad.mit.edu	37	chr9	77354692	77354692	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagattttatgccatgtccGcacaacctcaggaagaaagg	14	8	10	9	1	1	2	1	0	0	2	2	4	2	3	3	2	2	1	3	2	5	2			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr9:77354692G>A	uc004ajl.1	-	34	5672	c.5434C>T	c.(5434-5436)CGG>TGG	p.R1812W	TRPM6_uc004ajk.1_Missense_Mutation_p.R1807W|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.R763W|TRPM6_uc010mpd.1_Missense_Mutation_p.R645W|TRPM6_uc010mpe.1_Missense_Mutation_p.R359W|TRPM6_uc004ajj.1_Missense_Mutation_p.R768W	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1812	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TGCCATGTCCGCACAACCTCA	0.488													5	183					0	0	0	0	A	77354692	A	A	77354692	3	1	182	1	0	0	0	0	1	0	0	0	16657	1086	38	1	658	1	TRPM6	9	77354692	Missense_Mutation	SNP	G	TCGA-CV-5971-01A-11D-1683-08	5362361	77354692	63858739	18	34187											
KIAA0649	9858	broad.mit.edu	37	chr9	138379027	138379027	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccgcctggcgtgtgcacaCgcagccagagggccaggggg	7	3	17	14	3	0	1	0	0	0	1	0	1	0	1	4	4	2	2	4	4	0	0			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr9:138379027C>T	uc004cfr.1	+	4	3220	c.2671C>T	c.(2671-2673)CGC>TGC	p.R891C		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	891						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		CGTGTGCACACGCAGCCAGAG	0.697													15	57					0	0	0	0	T	138379027	T	T	138379027	3	4	182	1	0	0	0	0	1	0	0	0	8226	536	19	1	2673	1	KIAA0649	9	138379027	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08	61024335	138379027	2834404	19	34188											
NOTCH1	4851	broad.mit.edu	37	chr9	139413085	139413085	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagtagaaggaggccacacGgtcatggcaggtggcgccgt	9	5	17	10	3	1	1	1	0	0	1	1	2	1	2	2	6	0	3	2	6	2	1			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr9:139413085G>A	uc004chz.2	-	6	1057	c.1057C>T	c.(1057-1059)CGT>TGT	p.R353C		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	353	Extracellular (Potential).|EGF-like 9; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.R353H(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GAGGCCACACGGTCATGGCAG	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			3	16					0	0	0	0	A	139413085	A	A	139413085	3	1	182	1	0	0	0	0	1	0	0	0	10601	1116	39	1	6726	1	NOTCH1	9	139413085	Missense_Mutation	SNP	G	TCGA-CV-5971-01A-11D-1683-08	1034058	139413085	1800346	20	34189											
CAMK1D	57118	broad.mit.edu	37	chr10	12867572	12867572	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttcctttctgaaatttcagCaagcatttaatgccacggcc	10	14	6	11	1	2	1	1	1	1	0	3	1	3	1	3	1	3	2	3	1	3	5			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr10:12867572C>G	uc001ilo.2	+	10	1157	c.922C>G	c.(922-924)CAA>GAA	p.Q308E	CAMK1D_uc001iln.2_Missense_Mutation_p.Q308E	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	308	Autoinhibitory domain (By similarity).|Calmodulin-binding (By similarity).					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		GAAATTTCAGCAAGCATTTAA	0.413													5	80					0	0	0	0	G	12867572	G	G	12867572	3	3	182	1	0	0	0	0	1	0	0	0	2609	724	25	4	960	4	CAMK1D	10	12867572	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08		12867572	122667175	21	34190											
PKD2L1	9033	broad.mit.edu	37	chr10	102056008	102056008	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cccatgagccgattcacctcGagggttcggaatatgtggaa	10	9	12	10	3	1	1	1	1	0	0	3	5	1	3	3	3	1	1	3	3	3	3			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr10:102056008G>C	uc001kqx.1	-	7	1610	c.1227C>G	c.(1225-1227)CTC>CTG	p.L409L	PKD2L1_uc009xwm.1_Silent_p.L362L	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	409	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		GATTCACCTCGAGGGTTCGGA	0.542													3	28					0	0	0	0	C	102056008	C	C	102056008	2	2	182	1	0	0	0	0	0	0	0	1	12022	1045	37	3		3	PKD2L1	10	102056008	Silent	SNP	G	TCGA-CV-5971-01A-11D-1683-08	89188436	102056008	33478739	22	34191											
SUFU	51684	broad.mit.edu	37	chr10	104359280	104359280	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caaccctcagcggcagaatgGcctcgcccacgaccgggccc	8	3	11	19	4	1	1	1	0	0	1	2	2	1	1	5	3	2	1	5	3	2	0			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr10:104359280G>A	uc001kvy.1	+	8	1147	c.1001G>A	c.(1000-1002)GGC>GAC	p.G334D	SUFU_uc001kvw.1_Missense_Mutation_p.G334D|SUFU_uc001kvx.2_Missense_Mutation_p.G334D|SUFU_uc009xxe.1_RNA|SUFU_uc009xxf.1_RNA	NM_016169	NP_057253	Q9UMX1	SUFU_HUMAN	suppressor of fused	334					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			central_nervous_system(4)|skin(2)|breast(1)	7		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)		CGGCAGAATGGCCTCGCCCAC	0.582			D|F|S		medulloblastoma	medulloblastoma			Medulloblastoma_associated_with_Germline_SUFU_Mutation				6	51					0	0	0	0	A	104359280	A	A	104359280	3	1	182	1	0	0	0	0	1	0	0	0	15434	1203	42	4	1031	4	SUFU	10	104359280	Missense_Mutation	SNP	G	TCGA-CV-5971-01A-11D-1683-08	2303272	104359280	31175467	23	34192											
TRIM8	81603	broad.mit.edu	37	chr10	104415877	104415877	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacagaacaccaagtctgtGaaaatcctgatggacaggta	16	7	9	9	0	1	3	0	2	1	1	2	4	2	4	2	2	2	1	2	2	6	1			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr10:104415877G>A	uc001kvz.2	+	4	1038	c.915G>A	c.(913-915)GTG>GTA	p.V305V		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	305						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCAAGTCTGTGAAAATCCTGA	0.637													5	209					0	0	0	0	A	104415877	A	A	104415877	2	1	182	1	0	0	0	0	0	0	0	1	16615	1277	45	2		2	TRIM8	10	104415877	Silent	SNP	G	TCGA-CV-5971-01A-11D-1683-08	56597	104415877	31118870	24	34193											
PATL1	219988	broad.mit.edu	37	chr11	59420024	59420024	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccatcaccttgtatttcttCagcagctgacagtttctcca	8	14	6	13	0	4	1	2	1	2	0	5	1	4	1	3	0	2	4	3	0	1	5			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr11:59420024C>T	uc001noe.3	-	11	1482	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K	PATL1_uc009yms.1_Missense_Mutation_p.E417K|PATL1_uc010rkw.1_Missense_Mutation_p.E152K	NM_152716	NP_689929	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog	447	Region H.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			ovary(1)	1						TGTATTTCTTCAGCAGCTGAC	0.458													4	62					0	0	0	0	T	59420024	T	T	59420024	3	4	182	1	0	0	0	0	1	0	0	0	11529	835	29	2	1009	2	PATL1	11	59420024	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08		59420024	75586492	25	34194											
C11orf53	341032	broad.mit.edu	37	chr11	111154935	111154935	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtttccctgtgagtcctccGcagggcagagccatgcggct	5	9	13	14	3	0	2	0	1	0	1	3	2	3	2	4	2	2	4	4	2	0	1			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr11:111154935G>A	uc001plc.2	+	3	289	c.142G>A	c.(142-144)GCA>ACA	p.A48T		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	48											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		TGAGTCCTCCGCAGGGCAGAG	0.582													7	178					0	0	0	0	A	111154935	A	A	111154935	3	1	182	1	0	0	0	0	1	0	0	0	1654	1087	38	1	148	1	C11orf53	11	111154935	Missense_Mutation	SNP	G	TCGA-CV-5971-01A-11D-1683-08	51734911	111154935	23851581	26	34195											
ESR2	2100	broad.mit.edu	37	chr14	64746775	64746775	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgatatcccgatgcgtaatcGctgcagacagcgcagaagtg	11	8	12	10	4	0	3	0	1	0	2	2	4	1	3	1	0	3	4	1	0	3	2			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr14:64746775G>A	uc001xha.1	-	3	927	c.459C>T	c.(457-459)AGC>AGT	p.S153S	ESR2_uc001xgu.2_Silent_p.S153S|ESR2_uc001xgv.2_Silent_p.S153S|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Silent_p.S153S|ESR2_uc001xgy.1_Silent_p.S153S|ESR2_uc001xgz.1_Silent_p.S153S|ESR2_uc010aqb.1_Intron|ESR2_uc010aqc.1_Silent_p.S153S	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	153	NR C4-type.|Nuclear receptor.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	ATGCGTAATCGCTGCAGACAG	0.473													12	207					0	0	0	0	A	64746775	A	A	64746775	2	1	182	1	0	0	0	0	0	0	0	1	5281	1078	38	1		1	ESR2	14	64746775	Silent	SNP	G	TCGA-CV-5971-01A-11D-1683-08		64746775	42602765	27	34196											
GALNT1	2589	broad.mit.edu	37	chr18	33283589	33283589	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacctaaaaggcaaccaactCtgggagtatgacccagtggt	13	7	10	11	0	1	1	0	1	1	0	1	2	1	2	3	3	2	2	3	3	5	2			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr18:33283589C>G	uc010dmu.2	+	11	1568	c.1515C>G	c.(1513-1515)CTC>CTG	p.L505L	GALNT1_uc002kyz.3_Silent_p.L445L|GALNT1_uc002kzb.2_Silent_p.L505L	NM_020474	NP_065207	Q10472	GALT1_HUMAN	polypeptide N-acetylgalactosaminyltransferase 1	505	Lumenal (Potential).|Ricin B-type lectin.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GCAACCAACTCTGGGAGTATG	0.373													4	50					0	0	0	0	G	33283589	G	G	33283589	2	3	182	1	0	0	0	0	0	0	0	1	6242	900	32	2		2	GALNT1	18	33283589	Silent	SNP	C	TCGA-CV-5971-01A-11D-1683-08		33283589	44793659	28	34197											
NOVA2	4858	broad.mit.edu	37	chr19	46444042	46444042	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acggccttgtgcacctgctcGggctcgccgctgaccgtcac	4	8	12	17	5	1	1	1	1	0	0	3	1	1	1	4	2	2	4	4	2	0	1			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr19:46444042G>A	uc002pdv.2	-	4	606	c.558C>T	c.(556-558)CCC>CCT	p.P186P		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	186	KH 2.					nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		GCACCTGCTCGGGCTCGCCGC	0.632													3	34					0	0	0	0	A	46444042	A	A	46444042	2	1	182	1	0	0	0	0	0	0	0	1	10609	1103	39	1		1	NOVA2	19	46444042	Silent	SNP	G	TCGA-CV-5971-01A-11D-1683-08		46444042	12684941	29	34198											
MAPK1	5594	broad.mit.edu	37	chr22	22127164	22127164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggaacatgagctcttacctCgtcactcgggtcgtaatact	10	11	9	11	3	2	1	1	1	1	0	5	2	2	2	1	2	4	2	1	2	4	3			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr22:22127164C>T	uc002zvn.2	-	7	1204	c.964G>A	c.(964-966)GAG>AAG	p.E322K	MAPK1_uc002zvo.2_Missense_Mutation_p.E322K|MAPK1_uc010gtk.1_Missense_Mutation_p.E278K	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	322					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	GCTCTTACCTCGTCACTCGGG	0.478													3	45					0	0	0	0	T	22127164	T	T	22127164	3	4	182	1	0	0	0	0	1	0	0	0	9324	893	31	1	126	1	MAPK1	22	22127164	Missense_Mutation	SNP	C	TCGA-CV-5971-01A-11D-1683-08		22127164	29177402	30	34199											
SLC2A11	66035	broad.mit.edu	37	chr22	24204324	24204324	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctgctcctgaccatctgcGctgccggcattggtgggact	4	11	12	14	2	1	1	0	1	1	0	3	2	3	2	4	3	3	3	4	3	0	1			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr22:24204324G>A	uc002zyn.3	+	2	154	c.55G>A	c.(55-57)GCT>ACT	p.A19T	SLC2A11_uc002zyl.1_Missense_Mutation_p.A26T|SLC2A11_uc002zym.3_Missense_Mutation_p.A26T|SLC2A11_uc002zyo.3_RNA|SLC2A11_uc011ajc.1_Missense_Mutation_p.A26T|SLC2A11_uc011ajd.1_Missense_Mutation_p.A13T|SLC2A11_uc002zyp.3_Missense_Mutation_p.A22T	NM_001024938	NP_001020109	Q9BYW1	GTR11_HUMAN	glucose transporter protein 10 isoform c	19	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity			ovary(1)	1						GACCATCTGCGCTGCCGGCAT	0.557													4	156					0	0	0	0	A	24204324	A	A	24204324	3	1	182	1	0	0	0	0	1	0	0	0	14604	1087	38	1	141	1	SLC2A11	22	24204324	Missense_Mutation	SNP	G	TCGA-CV-5971-01A-11D-1683-08	2077160	24204324	27100242	31	34200											
APOBEC3B	9582	broad.mit.edu	37	chr22	39387498	39387498	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtgccggggaagtgcgtgcGttccttcaggagaacacaca	9	8	14	10	3	1	1	1	0	0	1	2	3	2	2	2	3	4	1	2	3	2	2			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr22:39387498G>A	uc003awo.1	+	6	939	c.885G>A	c.(883-885)GCG>GCA	p.A295A	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Silent_p.A270A|APOBEC3B_uc003awq.1_RNA|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	295					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding	p.A295V(1)		ovary(1)	1	Melanoma(58;0.04)					AAGTGCGTGCGTTCCTTCAGG	0.577													5	105					0	0	0	0	A	39387498	A	A	39387498	2	1	182	1	0	0	0	0	0	0	0	1	790	1132	40	1		1	APOBEC3B	22	39387498	Silent	SNP	G	TCGA-CV-5971-01A-11D-1683-08	15183174	39387498	11917068	32	34201											
ENTHD1	150350	broad.mit.edu	37	chr22	40283601	40283601	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagcatattcataatctctGagagagaaattgtgttgaaa	16	12	8	5	0	2	3	1	2	1	2	3	5	2	3	0	0	1	2	0	0	4	5			TCGA-CV-5971-01A-11D-1683-08	TCGA-CV-5971-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	881a530b-fdd2-4674-b95d-fded0dfce4ff	cd1d0b67-31b2-49c8-abcc-bb2aebb05646	g.chr22:40283601G>C	uc003ayg.2	-	2	403	c.152C>G	c.(151-153)TCA>TGA	p.S51*		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	51	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					CATAATCTCTGAGAGAGAAAT	0.418													3	126					0	0	0	0	C	40283601	C	C	40283601	4	2	182	1	0	0	0	0	0	1	0	0	5161	1294	45	2	1695	2	ENTHD1	22	40283601	Nonsense_Mutation	SNP	G	TCGA-CV-5971-01A-11D-1683-08	896103	40283601	11020965	33	34202											
PTCH2	8643	broad.mit.edu	37	chr1	45292686	45292686	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtcactgctcacccacacGgtcagccccatgtagaagag	10	6	11	14	1	3	2	3	0	0	2	3	2	3	2	3	2	2	2	3	2	2	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr1:45292686G>T	uc010olf.1	-	17	2595	c.2583C>A	c.(2581-2583)ACC>ACA	p.T861T	PTCH2_uc010olg.1_Silent_p.T559T	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	861	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					TCACCCACACGGTCAGCCCCA	0.622									Basal_Cell_Nevus_syndrome				39	189					4.14481e-20	4.617e-20	1	0	T	45292686	T	T	45292686	2	4	183	1	0	0	0	0	0	0	0	1	12793	1103	39	3		3	PTCH2	1	45292686	Silent	SNP	G	TCGA-CV-5973-01A-11D-1683-08		45292686	203957935	1	34203											
SETDB1	9869	broad.mit.edu	37	chr1	150923168	150923168	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctctgctggtcccgttactAtatgacttccggcggatgac	6	12	10	13	3	1	2	0	2	1	0	3	3	3	3	3	3	2	2	3	3	3	4			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr1:150923168A>G	uc001evu.2	+	13	2005	c.1815A>G	c.(1813-1815)CTA>CTG	p.L605L	SETDB1_uc009wmf.2_Silent_p.L606L|SETDB1_uc001evv.2_Silent_p.L605L|SETDB1_uc009wmg.1_Silent_p.L605L	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	605	MBD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCCCGTTACTATATGACTTCC	0.517													37	38					0	0	0	0	G	150923168	G	G	150923168	2	3	183	1	0	0	0	0	0	0	0	1	14203	436	16	5		5	SETDB1	1	150923168	Silent	SNP	A	TCGA-CV-5973-01A-11D-1683-08	105630482	150923168	98327453	2	34204											
C1orf125	126859	broad.mit.edu	37	chr1	179497484	179497484	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accttcaacatctacagagaAggaaaaactcattcgattca	17	9	5	10	1	4	1	3	0	1	1	5	4	4	2	1	1	3	0	1	1	5	4			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr1:179497484A>T	uc001gmo.2	+	23	2760	c.2633A>T	c.(2632-2634)AAG>ATG	p.K878M	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.K804M|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	878	Glu-rich.							p.K878M(1)			0						TCTACAGAGAAGGAAAAACTC	0.428													13	38					0	0	0	0	T	179497484	T	T	179497484	3	4	183	1	0	0	0	0	1	0	0	0	2002	72	3	5	2719	5	C1orf125	1	179497484	Missense_Mutation	SNP	A	TCGA-CV-5973-01A-11D-1683-08	28574316	179497484	69753137	3	34205											
ASPM	259266	broad.mit.edu	37	chr1	197111689	197111689	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgaagctgttgtcgaagAgggtgttacctcgtttttat	9	15	11	6	2	0	2	0	1	0	1	2	3	0	2	1	1	3	4	1	1	5	5			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr1:197111689A>T	uc001gtu.2	-	3	1950	c.1693T>A	c.(1693-1695)TCT>ACT	p.S565T	ASPM_uc001gtv.2_Missense_Mutation_p.S565T|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	565					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GTTGTCGAAGAGGGTGTTACC	0.343													27	83					0	0	0	0	T	197111689	T	T	197111689	3	4	183	1	0	0	0	0	1	0	0	0	1058	304	11	5	8844	5	ASPM	1	197111689	Missense_Mutation	SNP	A	TCGA-CV-5973-01A-11D-1683-08	17614205	197111689	52138932	4	34206											
CD55	1604	broad.mit.edu	37	chr1	207504538	207504538	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggatatagacagtctgtaacGtatgcatgtaataaaggatt	15	12	10	4	1	1	1	0	0	1	1	1	3	1	3	0	2	2	4	0	2	7	7			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr1:207504538G>A	uc001hfq.3	+	6	1044	c.750G>A	c.(748-750)ACG>ACA	p.T250T	CD55_uc001hfp.3_Silent_p.T250T|CD55_uc001hfr.3_Silent_p.T250T|CD55_uc010psf.1_RNA|CD55_uc009xcf.2_Silent_p.T186T|CD55_uc009xce.2_Silent_p.T250T|CD55_uc009xcg.2_5'UTR	NM_000574	NP_000565	P08174	DAF_HUMAN	decay accelerating factor for complement isoform	250	Sushi 4.				complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			ovary(1)	1					Chloramphenicol(DB00446)	AGTCTGTAACGTATGCATGTA	0.383													33	78					0	0	0	0	A	207504538	A	A	207504538	2	1	183	1	0	0	0	0	0	0	0	1	3039	1132	40	1		1	CD55	1	207504538	Silent	SNP	G	TCGA-CV-5973-01A-11D-1683-08	10392849	207504538	41746083	5	34207											
OR2T11	127077	broad.mit.edu	37	chr1	248789870	248789870	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttcatacaaggacgtgtctGcacaggccagtttcagaact	11	11	9	10	1	3	1	2	0	1	1	3	2	3	2	1	2	3	2	1	2	3	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr1:248789870G>T	uc001ier.1	-	1	560	c.560C>A	c.(559-561)GCA>GAA	p.A187E		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGACGTGTCTGCACAGGCCAG	0.468													16	72					2.35188e-11	2.55513e-11	1	0	T	248789870	T	T	248789870	3	4	183	1	0	0	0	0	1	0	0	0	11072	1319	46	4	394	4	OR2T11	1	248789870	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	41285332	248789870	460751	6	34208											
GALNT14	79623	broad.mit.edu	37	chr2	31155016	31155016	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccactcggctgcaggggaCgatctctaggctgcccccgc	5	6	12	18	3	1	0	0	0	1	0	3	2	1	1	4	4	2	3	4	4	1	1	rs139793019	byFrequency	TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr2:31155016C>T	uc002rnr.2	-	10	1595	c.976G>A	c.(976-978)GTC>ATC	p.V326I	GALNT14_uc002rnq.2_Missense_Mutation_p.V306I|GALNT14_uc002rns.2_Missense_Mutation_p.V331I|GALNT14_uc010ymr.1_Missense_Mutation_p.V291I|GALNT14_uc010ezo.1_Missense_Mutation_p.V293I|GALNT14_uc010ezp.1_3'UTR	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	326	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.V326I(1)		upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					CTGCAGGGGACGATCTCTAGG	0.557													9	49					0	0	0	0	T	31155016	T	T	31155016	3	4	183	1	0	0	0	0	1	0	0	0	6247	536	19	1	706	1	GALNT14	2	31155016	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08		31155016	212044357	7	34209											
NRXN1	9378	broad.mit.edu	37	chr2	50280513	50280513	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacatctctgattgcatggCagtggctgttgactcagttg	7	13	13	8	0	2	2	1	2	1	0	3	3	2	3	0	3	1	5	0	3	0	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr2:50280513C>T	uc010fbp.2	-	4	1636	c.829G>A	c.(829-831)GCC>ACC	p.A277T	NRXN1_uc002rxb.3_Missense_Mutation_p.A1014T|NRXN1_uc010fbq.2_Missense_Mutation_p.A1382T|NRXN1_uc002rxe.3_Missense_Mutation_p.A1312T	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	277	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GATTGCATGGCAGTGGCTGTT	0.498													17	72					0	0	0	0	T	50280513	T	T	50280513	3	4	183	1	0	0	0	0	1	0	0	0	10719	710	25	4	511	4	NRXN1	2	50280513	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	19125497	50280513	192918860	8	34210											
CNGA3	1261	broad.mit.edu	37	chr2	99013496	99013496	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagctggccagggcgggcgcGgaccccaaggaccttgagga	8	3	18	12	3	0	1	0	1	0	0	0	5	0	4	4	6	1	1	4	6	1	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr2:99013496G>A	uc002syt.2	+	8	2280	c.1863G>A	c.(1861-1863)GCG>GCA	p.A621A	CNGA3_uc002syu.2_Silent_p.A603A|CNGA3_uc010fij.2_Silent_p.A625A	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	621					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						GGGCGGGCGCGGACCCCAAGG	0.622													31	19					0	0	0	0	A	99013496	A	A	99013496	2	1	183	1	0	0	0	0	0	0	0	1	3613	1103	39	1		1	CNGA3	2	99013496	Silent	SNP	G	TCGA-CV-5973-01A-11D-1683-08	48732983	99013496	144185877	9	34211											
SH3RF3	344558	broad.mit.edu	37	chr2	109964267	109964267	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtaccacggcgagctgcaCggcacacagggcttcctccc	7	6	12	16	3	0	0	0	0	0	0	2	1	2	0	3	4	3	5	3	4	1	2			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr2:109964267C>T	uc010ywt.1	+	2	711	c.711C>T	c.(709-711)CAC>CAT	p.H237H		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	237	SH3 1.						zinc ion binding			ovary(1)	1						GCGAGCTGCACGGCACACAGG	0.587													6	20					0	0	0	0	T	109964267	T	T	109964267	2	4	183	1	0	0	0	0	0	0	0	1	14325	535	19	1		1	SH3RF3	2	109964267	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08	10950771	109964267	133235106	10	34212											
RBM43	375287	broad.mit.edu	37	chr2	152112091	152112091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcaactcccttggttcttGtcggatatatcacatcttca	9	15	6	11	1	4	0	2	0	2	0	6	1	5	1	1	2	2	2	1	2	3	6			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr2:152112091G>A	uc002txh.2	-	2	318	c.170C>T	c.(169-171)ACA>ATA	p.T57I		NM_198557	NP_940959	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	57	RRM.						nucleotide binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		CTTGGTTCTTGTCGGATATAT	0.318													45	63					0	0	0	0	A	152112091	A	A	152112091	3	1	183	1	0	0	0	0	1	0	0	0	13202	1377	48	4	915	4	RBM43	2	152112091	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	42147824	152112091	91087282	11	34213											
RNF25	64320	broad.mit.edu	37	chr2	219529928	219529928	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgaggcaagatcatacaCgaggggctctctgcacactg	11	7	12	11	1	2	2	1	1	1	1	3	3	2	2	0	3	2	3	0	3	2	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr2:219529928C>T	uc002vit.2	-	8	704	c.616G>A	c.(616-618)GTG>ATG	p.V206M	RNF25_uc010fvw.2_Missense_Mutation_p.V94M	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	206					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGATCATACACGAGGGGCTCT	0.498													6	20					0	0	0	0	T	219529928	T	T	219529928	3	4	183	1	0	0	0	0	1	0	0	0	13550	536	19	1	775	1	RNF25	2	219529928	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	67417837	219529928	23669445	12	34214											
PTPRN	5798	broad.mit.edu	37	chr2	220164844	220164844	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acagggggtctggcagctttGggaggctcagaggagacagg	9	6	19	7	0	2	2	1	0	1	2	2	4	2	3	0	7	1	3	0	7	0	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr2:220164844G>A	uc002vkz.2	-	9	1388	c.1299C>T	c.(1297-1299)CCC>CCT	p.P433P	PTPRN_uc010zlc.1_Silent_p.P343P|PTPRN_uc002vla.2_Silent_p.P433P	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	433	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TGGCAGCTTTGGGAGGCTCAG	0.652													31	52					0	0	0	0	A	220164844	A	A	220164844	2	1	183	1	0	0	0	0	0	0	0	1	12872	1335	47	4		4	PTPRN	2	220164844	Silent	SNP	G	TCGA-CV-5973-01A-11D-1683-08	634916	220164844	23034529	13	34215											
HJURP	55355	broad.mit.edu	37	chr2	234750497	234750497	+	Frame_Shift_Del	DEL	C	-	-																															gagaacgtctggctcctttgCaatatgttttgttcatcctg																										TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr2:234750497delC	uc002vvg.2	-	8	995	c.929delG	c.(928-930)TGCfs	p.C310fs	HJURP_uc010znd.1_Frame_Shift_Del_p.C249fs|HJURP_uc010zne.1_Frame_Shift_Del_p.C218fs	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	310					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		GGCTCCTTTGCAATATGTTTT	0.468													---	---	---								-	234750497	-	-	234750497	7	5	183	1	0	1	0	1	0	0	0	0	7228	710	25	0	1325	0	HJURP	2	234750497	Frame_Shift_Del	DEL	C	TCGA-CV-5973-01A-11D-1683-08	14585653	234750497	8448876	14	34216											
MAP4	4134	broad.mit.edu	37	chr3	47912432	47912432	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtggagctgggtttggcCgaggtgggcttcttgtctat	3	14	18	6	1	2	0	0	0	2	0	2	2	2	1	1	6	1	3	1	6	1	4	rs146957827		TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr3:47912432C>T	uc003csb.2	-	13	3256	c.2730G>A	c.(2728-2730)TCG>TCA	p.S910S	MAP4_uc003csc.3_Silent_p.S910S|MAP4_uc003crw.2_Silent_p.S42S|MAP4_uc003crx.2_Silent_p.S170S|MAP4_uc011bbe.1_Silent_p.S661S|MAP4_uc003cry.2_Silent_p.S645S|MAP4_uc003csa.3_Silent_p.S645S|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Silent_p.S645S	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	910					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGGGTTTGGCCGAGGTGGGCT	0.632													27	39					0	0	0	0	T	47912432	T	T	47912432	2	4	183	1	0	0	0	0	0	0	0	1	9311	639	23	1		1	MAP4	3	47912432	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08		47912432	150109998	15	34217											
CACNA1D	776	broad.mit.edu	37	chr3	53842756	53842756	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcccgtcgtctcccatcttcCcccatcgcacggccctgcct	3	10	6	22	4	2	0	0	0	2	0	7	0	4	0	6	1	1	1	6	1	0	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr3:53842756C>T	uc003dgv.3	+	46	5993	c.5830C>T	c.(5830-5832)CCC>TCC	p.P1944S	CACNA1D_uc003dgu.3_Missense_Mutation_p.P1964S|CACNA1D_uc003dgy.3_Missense_Mutation_p.P1920S|CACNA1D_uc003dgw.3_Missense_Mutation_p.P1611S|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1944	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.P1964S(1)		ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TCCCATCTTCCCCCATCGCAC	0.637													15	31					0	0	0	0	T	53842756	T	T	53842756	3	4	183	1	0	0	0	0	1	0	0	0	2553	623	22	4	6184	4	CACNA1D	3	53842756	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	5930324	53842756	144179674	16	34218											
POLQ	10721	broad.mit.edu	37	chr3	121207697	121207697	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaagagttcattgagttctGttggactaagctcttctgca	11	14	9	7	0	4	2	1	1	3	1	4	3	4	3	0	1	2	5	0	1	3	6			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr3:121207697G>A	uc003eee.3	-	16	4210	c.4081C>T	c.(4081-4083)CAG>TAG	p.Q1361*	POLQ_uc003eed.2_Nonsense_Mutation_p.Q533*	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1361					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity	p.Q1496*(1)		ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		ATTGAGTTCTGTTGGACTAAG	0.438								DNA_polymerases_(catalytic_subunits)					25	153					0	0	0	0	A	121207697	A	A	121207697	4	1	183	1	0	0	0	0	0	1	0	0	12263	1386	48	4	3751	4	POLQ	3	121207697	Nonsense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	67364941	121207697	76814733	17	34219											
PPP2R3A	5523	broad.mit.edu	37	chr3	135722254	135722254	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcccaggccaatttatcAgtctgtagaagtcctgttgg	8	13	9	11	0	2	1	1	0	1	1	5	1	5	1	4	2	0	2	4	2	4	4			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr3:135722254A>T	uc003eqv.1	+	2	2479	c.1914A>T	c.(1912-1914)TCA>TCT	p.S638S	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	638					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						CCAATTTATCAGTCTGTAGAA	0.413													21	72					0	0	0	0	T	135722254	T	T	135722254	2	4	183	1	0	0	0	0	0	0	0	1	12448	175	7	5		5	PPP2R3A	3	135722254	Silent	SNP	A	TCGA-CV-5973-01A-11D-1683-08	14514557	135722254	62300176	18	34220											
CLDN22	53842	broad.mit.edu	37	chr4	184241208	184241209	+	Frame_Shift_Del	DEL	AC	-	-																															tccccacttcctcttggatgAcacaggtttgccagagtccc																										TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr4:184241208_184241209delAC	uc010isa.1	-	1	719_720	c.163_164delGT	c.(163-165)GTCfs	p.V55fs	WWC2_uc010irx.2_3'UTR|WWC2_uc003ivk.3_3'UTR|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_3'UTR|WWC2_uc003ivn.3_3'UTR|WWC2_uc010irz.2_3'UTR|WWC2_uc003ivo.3_3'UTR	NM_001111319	NP_001104789	Q8N7P3	CLD22_HUMAN	claudin 22	55	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.0172)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|Esophageal squamous(56;0.176)		all cancers(43;4.1e-26)|Epithelial(43;6.45e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|Colorectal(24;5.87e-06)|GBM - Glioblastoma multiforme(59;6.5e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		CTCTTGGATGACACAGGTTTGC	0.465													---	---	---								-	184241209	-	-	184241208	7	5	183	1	0	1	0	1	0	0	0	0	3498	275	10	0	502	0	CLDN22	4	184241208	Frame_Shift_Del	DEL	AC	TCGA-CV-5973-01A-11D-1683-08		184241208	6913068	19	34221											
TRIO	7204	broad.mit.edu	37	chr5	14378176	14378176	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtattgcattactggaccatGaggaagagacggctggacca	12	8	13	8	1	0	2	0	1	0	1	0	6	0	5	2	4	2	3	2	4	3	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr5:14378176G>A	uc003jff.2	+	20	3393	c.3387G>A	c.(3385-3387)ATG>ATA	p.M1129I	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.M1080I|TRIO_uc003jfh.1_Missense_Mutation_p.M778I	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1129	Spectrin 4.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.M1129I(1)		skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					ACTGGACCATGAGGAAGAGAC	0.493													4	8					0	0	0	0	A	14378176	A	A	14378176	3	1	183	1	0	0	0	0	1	0	0	0	16619	1290	45	2	3465	2	TRIO	5	14378176	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08		14378176	166537084	20	34222											
HLA-B	3106	broad.mit.edu	37	chr6	31322969	31322970	+	Frame_Shift_Del	DEL	CA	-	-																															gccaggccagcaacaatgccCacgatggggacggtggactg																										TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr6:31322969_31322970delCA	uc003nth.2	-	5	980_981	c.926_927delTG	c.(925-927)GTGfs	p.V309fs	HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_RNA|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Frame_Shift_Del_p.V188fs|HLA-B_uc003nti.1_Intron	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	309	Extracellular (Potential).|Connecting peptide.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						CAACAATGCCCACGATGGGGAC	0.589									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				---	---	---								-	31322970	-	-	31322969	7	5	183	1	0	1	0	1	0	0	0	0	7235	581	21	0	173	0	HLA-B	6	31322969	Frame_Shift_Del	DEL	CA	TCGA-CV-5973-01A-11D-1683-08		31322969	139792098	21	34223											
TULP1	7287	broad.mit.edu	37	chr6	35479474	35479474	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaggtttcccgggggtcGcgcttcttggcctcggggtc	4	10	16	11	4	1	1	0	0	1	1	5	1	2	1	2	6	0	2	2	6	1	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr6:35479474G>A	uc003okv.3	-	4	312	c.300C>T	c.(298-300)CGC>CGT	p.R100R	TULP1_uc003okw.3_Intron	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	100					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						CCCGGGGGTCGCGCTTCTTGG	0.726													4	7					0	0	0	0	A	35479474	A	A	35479474	2	1	183	1	0	0	0	0	0	0	0	1	16841	1074	38	1		1	TULP1	6	35479474	Silent	SNP	G	TCGA-CV-5973-01A-11D-1683-08	4156505	35479474	135635593	22	34224											
STK38	11329	broad.mit.edu	37	chr6	36485513	36485513	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctccaggcaggaactccatGattaggtagaggtttagctt	10	11	11	9	0	0	2	0	1	0	1	2	3	2	3	3	4	2	4	3	4	4	5			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr6:36485513G>C	uc003omg.2	-	5	1083	c.495C>G	c.(493-495)ATC>ATG	p.I165M	STK38_uc003omh.2_Missense_Mutation_p.I165M|STK38_uc003omi.2_Missense_Mutation_p.I165M	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	165	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity	p.I165M(1)		ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						GGAACTCCATGATTAGGTAGA	0.423													21	56					0	0	0	0	C	36485513	C	C	36485513	3	2	183	1	0	0	0	0	1	0	0	0	15369	1280	45	2	938	2	STK38	6	36485513	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	1006039	36485513	134629554	23	34225											
SLC22A16	85413	broad.mit.edu	37	chr6	110777895	110777895	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctggtcatatatgtagccatCcacacaaggaaactctttct	12	12	6	11	0	3	0	1	0	2	0	4	1	4	1	2	2	2	1	2	2	5	4			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr6:110777895C>T	uc003puf.2	-	2	446	c.379G>A	c.(379-381)GAT>AAT	p.D127N	SLC22A16_uc003pue.2_Missense_Mutation_p.D108N|SLC22A16_uc003pug.2_Missense_Mutation_p.D127N	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	127					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		ATGTAGCCATCCACACAAGGA	0.488													55	77					0	0	0	0	T	110777895	T	T	110777895	3	4	183	1	0	0	0	0	1	0	0	0	14512	855	30	2	1382	2	SLC22A16	6	110777895	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	74292382	110777895	60337172	24	34226											
TNRC18	84629	broad.mit.edu	37	chr7	5353056	5353057	+	Frame_Shift_Ins	INS	-	C	C																															gggctcctgccagccccccgINScccccggatcctcccggagc																										TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr7:5353056_5353057insC	uc003soi.3	-	27	7814_7815	c.7465_7466insG	c.(7465-7467)GCGfs	p.A2489fs		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2489							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CCAGCCCCCCGCCCCCGGATCC	0.688													---	---	---								C	5353057	C	C	5353056	7	5	183	1	0	1	1	0	0	0	0	0	16405	1087	38	0	1456	0	TNRC18	7	5353056	Frame_Shift_Ins	INS	-	TCGA-CV-5973-01A-11D-1683-08		5353056	153785607	25	34227											
ETV1	2115	broad.mit.edu	37	chr7	13935629	13935629	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatgtctgtcttcagcagTggacgctgattatctggaaa	9	13	10	9	1	4	1	1	1	3	0	5	3	5	3	1	2	1	2	1	2	2	2			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr7:13935629T>C	uc011jxq.1	-	14	2035	c.1296A>G	c.(1294-1296)CCA>CCG	p.P432P	ETV1_uc011jxn.1_Silent_p.P392P|ETV1_uc011jxo.1_Silent_p.P329P|ETV1_uc011jxp.1_Silent_p.P374P|ETV1_uc003ssw.3_Silent_p.P409P|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Silent_p.P414P|ETV1_uc011jxs.1_Silent_p.P414P	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	432					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						TCTTCAGCAGTGGACGCTGAT	0.498			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								11	17					0	0	0	0	C	13935629	C	C	13935629	2	2	183	1	0	0	0	0	0	0	0	1	5301	1683	59	5		5	ETV1	7	13935629	Silent	SNP	T	TCGA-CV-5973-01A-11D-1683-08	8582573	13935629	145203034	26	34228											
SLC4A2	6522	broad.mit.edu	37	chr7	150772826	150772826	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatctgctgctcatgccGcccaaacaccacccagatgt	9	8	7	17	1	2	1	1	0	1	1	2	1	2	1	4	0	5	3	4	0	1	0			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr7:150772826G>A	uc003wit.3	+	21	3691	c.3435G>A	c.(3433-3435)CCG>CCA	p.P1145P	SLC4A2_uc011kve.1_Silent_p.P1136P|SLC4A2_uc003wiu.3_Silent_p.P1131P|SLC4A2_uc003wiv.3_Silent_p.P339P|uc011kvf.1_Intron	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	1145	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCTCATGCCGCCCAAACACC	0.582													14	41					0	0	0	0	A	150772826	A	A	150772826	2	1	183	1	0	0	0	0	0	0	0	1	14718	1074	38	1		1	SLC4A2	7	150772826	Silent	SNP	G	TCGA-CV-5973-01A-11D-1683-08	136837197	150772826	8365837	27	34229											
PDLIM2	64236	broad.mit.edu	37	chr8	22438929	22438929	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccaaggacgctgacctccGgcctggagacataatcgtgg	10	6	13	12	3	0	2	0	1	0	1	2	4	1	3	4	4	1	1	4	4	2	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr8:22438929G>A	uc003xby.2	+	3	531	c.131G>A	c.(130-132)CGG>CAG	p.R44Q	PDLIM2_uc003xbx.1_Missense_Mutation_p.R44Q|PDLIM2_uc003xbz.2_Missense_Mutation_p.R44Q|PDLIM2_uc003xca.2_Missense_Mutation_p.R44Q|PDLIM2_uc003xcb.2_Missense_Mutation_p.R44Q|PDLIM2_uc003xcc.1_Missense_Mutation_p.R44Q	NM_021630	NP_067643	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 isoform 2	44	PDZ.					actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		GCTGACCTCCGGCCTGGAGAC	0.662													6	9					0	0	0	0	A	22438929	A	A	22438929	3	1	183	1	0	0	0	0	1	0	0	0	11734	1116	39	1	137	1	PDLIM2	8	22438929	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08		22438929	123925093	28	34230											
PRKDC	5591	broad.mit.edu	37	chr8	48852134	48852134	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcaaaaagtccatatccacGgatagcaatagataactcct	16	9	6	10	1	0	1	0	0	0	1	3	2	3	2	3	1	3	2	3	1	7	4			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr8:48852134G>A	uc003xqi.2	-	11	1147	c.1090C>T	c.(1090-1092)CGT>TGT	p.R364C	PRKDC_uc003xqj.2_Missense_Mutation_p.R364C|PRKDC_uc011ldh.1_Missense_Mutation_p.R364C	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	364					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CCATATCCACGGATAGCAATA	0.338								NHEJ					28	87					0	0	0	0	A	48852134	A	A	48852134	3	1	183	1	0	0	0	0	1	0	0	0	12583	1116	39	1	11599	1	PRKDC	8	48852134	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	26413205	48852134	97511888	29	34231											
KIAA1797	54914	broad.mit.edu	37	chr9	20944734	20944734	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccggaagctgtctgcgcaCgtagatgacagcgggagcca	9	6	14	12	4	1	2	0	1	1	1	2	4	2	4	2	2	4	3	2	2	2	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr9:20944734C>T	uc003zog.1	+	31	3879	c.3516C>T	c.(3514-3516)CAC>CAT	p.H1172H	KIAA1797_uc003zoh.1_Silent_p.H608H	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1172						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		TGTCTGCGCACGTAGATGACA	0.512													10	20					0	0	0	0	T	20944734	T	T	20944734	2	4	183	1	0	0	0	0	0	0	0	1	8297	535	19	1		1	KIAA1797	9	20944734	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08		20944734	120268697	30	34232											
CDKN2A	1029	broad.mit.edu	37	chr9	21974755	21974758	+	Frame_Shift_Del	DEL	CCGA	-	-																															agcgcccgcacctcctctacCcgaccccgggccgcggccgt																								rs104894097		TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr9:21974755_21974758delCCGA	uc003zpk.2	-	1	281_284	c.69_72delTCGG	c.(67-72)GGTCGGfs	p.G23fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Frame_Shift_Del_p.G23fs|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	23_24	ANK 1.		R -> P (in CMM2).|R -> Q (found in a patient with multiple primary melanoma; partial loss of CDK4 binding).|R -> C (in CMM2).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(23)|p.G23fs(2)|p.R24P(2)|p.R24Q(1)|p.R24fs*20(1)|p.R22fs*14(1)|p.G23G(1)|p.G23D(1)|p.G23fs*3(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCTCCTCTACCCGACCCCGGGCCG	0.74		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---								-	21974758	-	-	21974755	7	5	183	1	0	1	0	1	0	0	0	0	3176	610	22	0	611	0	CDKN2A	9	21974755	Frame_Shift_Del	DEL	CCGA	TCGA-CV-5973-01A-11D-1683-08	1030021	21974755	119238676	31	34233											
FOXB2	442425	broad.mit.edu	37	chr9	79635500	79635500	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccagcttggcaacgtcgtCagctccgtgtggccgcacgt	5	8	14	14	5	1	0	1	0	0	0	3	0	2	0	3	3	3	4	3	3	1	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr9:79635500C>T	uc004ako.1	+	1	930	c.930C>T	c.(928-930)GTC>GTT	p.V310V		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	310					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						GCAACGTCGTCAGCTCCGTGT	0.577													6	9					0	0	0	0	T	79635500	T	T	79635500	2	4	183	1	0	0	0	0	0	0	0	1	6025	813	29	2		2	FOXB2	9	79635500	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08	57660745	79635500	61577931	32	34234											
LRRC8A	56262	broad.mit.edu	37	chr9	131678563	131678563	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcccactgctcaagcgcagCggcttggtggtggaggagga	7	7	17	10	2	1	0	1	0	0	0	1	3	1	3	1	6	4	3	1	6	1	1	rs139232646		TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr9:131678563C>T	uc004bwl.3	+	4	2600	c.2346C>T	c.(2344-2346)AGC>AGT	p.S782S	LRRC8A_uc010myp.2_Silent_p.S782S|LRRC8A_uc010myq.2_Silent_p.S782S	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	782					pre-B cell differentiation	integral to membrane					0						TCAAGCGCAGCGGCTTGGTGG	0.682													6	12					0	0	0	0	T	131678563	T	T	131678563	2	4	183	1	0	0	0	0	0	0	0	1	9071	767	27	1		1	LRRC8A	9	131678563	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08	52043063	131678563	9534868	33	34235											
NOTCH1	4851	broad.mit.edu	37	chr9	139393696	139393696	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcatccaggtctgtggctcGgttccggatcaggatctggg	5	10	16	10	2	3	0	1	0	2	0	6	2	5	2	2	7	0	3	2	7	0	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr9:139393696G>A	uc004chz.2	-	32	5950	c.5950C>T	c.(5950-5952)CGA>TGA	p.R1984*		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1984	ANK 2.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.R1984*(1)|p.R1985*(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TCTGTGGCTCGGTTCCGGATC	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			16	15					0	0	0	0	A	139393696	A	A	139393696	4	1	183	1	0	0	0	0	0	1	0	0	10601	1124	39	1	1729	1	NOTCH1	9	139393696	Nonsense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	7715133	139393696	1819735	34	34236											
ZMYND11	10771	broad.mit.edu	37	chr10	294963	294963	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgtaaggaagaatttgtaGaagaaatcaagaagctggca	18	8	12	3	0	1	4	1	0	0	4	1	5	1	5	0	2	1	4	0	2	8	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr10:294963G>C	uc010pzt.1	+	14	2049	c.1621G>C	c.(1621-1623)GAA>CAA	p.E541Q	ZMYND11_uc001ifk.2_Missense_Mutation_p.E540Q|ZMYND11_uc010pzu.1_Missense_Mutation_p.E541Q|ZMYND11_uc010pzv.1_Missense_Mutation_p.E486Q|ZMYND11_uc010pzw.1_Missense_Mutation_p.E456Q|ZMYND11_uc001ifm.2_Missense_Mutation_p.E487Q|ZMYND11_uc010pzx.1_Missense_Mutation_p.E541Q|ZMYND11_uc001ifn.2_Missense_Mutation_p.E487Q|ZMYND11_uc009xhg.2_Missense_Mutation_p.E524Q|ZMYND11_uc009xhh.2_Missense_Mutation_p.E415Q|ZMYND11_uc010pzy.1_Missense_Mutation_p.E393Q	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	501	Interaction with human adenovirus E1A.				cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		AGAATTTGTAGAAGAAATCAA	0.388													5	35					0	0	0	0	C	294963	C	C	294963	3	2	183	1	0	0	0	0	1	0	0	0	17773	943	33	2	1671	2	ZMYND11	10	294963	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08		294963	135239784	35	34237											
C10orf140	387640	broad.mit.edu	37	chr10	21804807	21804807	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggatcagtctgcgaagaggGcaaatccgtagcaaattcag	14	7	12	8	2	3	1	2	0	1	1	4	3	4	2	1	2	2	3	1	2	4	2			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr10:21804807G>A	uc009xkd.2	-	4	4198	c.1945C>T	c.(1945-1947)CCC>TCC	p.P649S	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	568						nucleus	nucleotide binding			ovary(1)	1						TGCGAAGAGGGCAAATCCGTA	0.438													3	40					0	0	0	0	A	21804807	A	A	21804807	3	1	183	1	0	0	0	0	1	0	0	0	1601	1203	42	4	785	4	C10orf140	10	21804807	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	21509844	21804807	113729940	36	34238											
BMS1	9790	broad.mit.edu	37	chr10	43316394	43316394	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttaaggccctatcactcCacagggaactggtttcttgg	8	12	9	12	0	2	0	1	0	1	0	3	1	3	1	3	4	1	1	3	4	3	5			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr10:43316394C>T	uc001jaj.2	+	18	3321	c.2963C>T	c.(2962-2964)CCA>CTA	p.P988L		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	988					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						CCTATCACTCCACAGGGAACT	0.358													30	23					0	0	0	0	T	43316394	T	T	43316394	3	4	183	1	0	0	0	0	1	0	0	0	1475	594	21	4	3029	4	BMS1	10	43316394	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	21511587	43316394	92218353	37	34239											
FJX1	24147	broad.mit.edu	37	chr11	35641069	35641069	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggaccgacttaatccttttCgactacctgacggccaactt	9	12	7	13	3	0	1	0	1	0	0	2	4	1	2	4	2	2	0	4	2	3	5	rs77030854		TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr11:35641069C>T	uc001mwh.2	+	1	1335	c.885C>T	c.(883-885)TTC>TTT	p.F295F		NM_014344	NP_055159	Q86VR8	FJX1_HUMAN	four jointed box 1 precursor	295						extracellular space					0	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)				TAATCCTTTTCGACTACCTGA	0.647													7	38					0	0	0	0	T	35641069	T	T	35641069	2	4	183	1	0	0	0	0	0	0	0	1	5933	883	31	1		1	FJX1	11	35641069	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08		35641069	99365447	38	34240											
MYBPC3	4607	broad.mit.edu	37	chr11	47354867	47354867	+	Frame_Shift_Del	DEL	G	-	-																															gtcagtcacccggagatcctGgggaggacttggcttgtctg																										TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr11:47354867delG	uc001nfa.3	-	29	3263	c.3208delC	c.(3208-3210)CAGfs	p.Q1070fs		NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	1069	Fibronectin type-III 3.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		CGGAGATCCTGGGGAGGACTT	0.637													---	---	---								-	47354867	-	-	47354867	7	5	183	1	0	1	0	1	0	0	0	0	10066	1357	47	0	636	0	MYBPC3	11	47354867	Frame_Shift_Del	DEL	G	TCGA-CV-5973-01A-11D-1683-08	11713798	47354867	87651649	39	34241											
MS4A2	2206	broad.mit.edu	37	chr11	59860935	59860935	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggggaacgggaattaccatCctgatcatcaacctgaagaa	14	7	11	9	1	2	3	2	2	0	1	3	5	3	5	3	3	3	0	3	3	6	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr11:59860935C>T	uc001nop.2	+	5	543	c.441C>T	c.(439-441)ATC>ATT	p.I147I	MS4A2_uc009ymu.2_Silent_p.I147I	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	147	Helical; (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	GAATTACCATCCTGATCATCA	0.478													28	83					0	0	0	0	T	59860935	T	T	59860935	2	4	183	1	0	0	0	0	0	0	0	1	9913	845	30	2		2	MS4A2	11	59860935	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08	12506068	59860935	75145581	40	34242											
NRXN2	9379	broad.mit.edu	37	chr11	64419615	64419615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgccccgcaaacagcgtttCggggcctttacctgcggcac	6	8	12	15	4	0	0	0	0	0	0	1	0	0	0	4	3	5	3	4	3	2	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr11:64419615C>T	uc001oar.2	-	14	2867	c.2428G>A	c.(2428-2430)GAA>AAA	p.E810K	NRXN2_uc001oas.2_Missense_Mutation_p.E770K|NRXN2_uc001oaq.2_Missense_Mutation_p.E477K	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane		p.E810K(1)		upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						AACAGCGTTTCGGGGCCTTTA	0.577													6	42					0	0	0	0	T	64419615	T	T	64419615	3	4	183	1	0	0	0	0	1	0	0	0	10720	893	31	1	3023	1	NRXN2	11	64419615	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	4558680	64419615	70586901	41	34243											
ARAP1	116985	broad.mit.edu	37	chr11	72412741	72412741	+	Frame_Shift_Del	DEL	T	-	-																															gcttgccggcagaggcagtcTtgtagaggaagccactgtgg																										TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr11:72412741delT	uc001osu.2	-	16	2444	c.2255delA	c.(2254-2256)AAGfs	p.K752fs	ARAP1_uc001osv.2_Frame_Shift_Del_p.K752fs|ARAP1_uc001osr.2_Frame_Shift_Del_p.K512fs|ARAP1_uc001oss.2_Frame_Shift_Del_p.K507fs|ARAP1_uc009yth.2_Frame_Shift_Del_p.K446fs|ARAP1_uc010rre.1_Frame_Shift_Del_p.K507fs|ARAP1_uc001osw.1_Frame_Shift_Del_p.K40fs	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	752	PH 3.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						AGAGGCAGTCTTGTAGAGGAA	0.627													---	---	---								-	72412741	-	-	72412741	7	5	183	1	0	1	0	1	0	0	0	0	838	1609	56	0	2177	0	ARAP1	11	72412741	Frame_Shift_Del	DEL	T	TCGA-CV-5973-01A-11D-1683-08	7993126	72412741	62593775	42	34244											
GNB3	2784	broad.mit.edu	37	chr12	6954826	6954826	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttgacctgcgggcagaccAggagctgatctgcttctccc	6	10	12	13	1	2	3	0	2	2	1	3	4	2	4	3	2	3	4	3	2	0	2			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr12:6954826A>G	uc001qrd.2	+	10	1181	c.776A>G	c.(775-777)CAG>CGG	p.Q259R	GNB3_uc001qrc.2_Missense_Mutation_p.Q215R|GNB3_uc009zfe.2_Missense_Mutation_p.Q258R|CDCA3_uc001qre.2_3'UTR|uc001qrf.1_RNA	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	259					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						CGGGCAGACCAGGAGCTGATC	0.617													69	117					0	0	0	0	G	6954826	G	G	6954826	3	3	183	1	0	0	0	0	1	0	0	0	6556	188	7	5	806	5	GNB3	12	6954826	Missense_Mutation	SNP	A	TCGA-CV-5973-01A-11D-1683-08		6954826	126897069	43	34245											
TUBA1B	10376	broad.mit.edu	37	chr12	49522572	49522572	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actacagctgtggaaacctgGggtgctgggtaaatggagaa	12	8	15	6	0	0	1	0	0	0	1	0	3	0	2	1	5	4	3	1	5	5	2			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr12:49522572G>A	uc001rto.2	-	3	522	c.420C>T	c.(418-420)CCC>CCT	p.P140P	TUBA1B_uc001rtk.2_Silent_p.P140P|TUBA1B_uc001rtl.2_Silent_p.P140P|TUBA1B_uc001rtn.2_Silent_p.P22P|TUBA1B_uc001rtm.2_Silent_p.P175P|uc010smg.1_Missense_Mutation_p.G135R	NM_006082	NP_006073	P68363	TBA1B_HUMAN	tubulin, alpha, ubiquitous	175					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding				0						TGGAAACCTGGGGTGCTGGGT	0.537													4	27					0	0	0	0	A	49522572	A	A	49522572	2	1	183	1	0	0	0	0	0	0	0	1	16812	1219	43	4		4	TUBA1B	12	49522572	Silent	SNP	G	TCGA-CV-5973-01A-11D-1683-08	42567746	49522572	84329323	44	34246											
CPM	1368	broad.mit.edu	37	chr12	69264160	69264160	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggaaatttcgattcaagtCatactggttataattttccc	11	15	8	7	1	2	0	2	0	0	0	4	2	3	1	1	3	1	1	1	3	5	7			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr12:69264160C>T	uc001sup.2	-	5	512	c.451G>A	c.(451-453)GAC>AAC	p.D151N	CPM_uc001sur.2_Missense_Mutation_p.D151N|CPM_uc001suq.2_Missense_Mutation_p.D151N	NM_198320	NP_938079	P14384	CBPM_HUMAN	carboxypeptidase M precursor	151					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding				0	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			CGATTCAAGTCATACTGGTTA	0.388													23	24					0	0	0	0	T	69264160	T	T	69264160	3	4	183	1	0	0	0	0	1	0	0	0	3823	826	29	2	900	2	CPM	12	69264160	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	19741588	69264160	64587735	45	34247											
NAV3	89795	broad.mit.edu	37	chr12	78400845	78400845	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaagcttgatccctaagggCagcaagacaacagcagctaa	15	5	10	11	0	0	2	0	1	0	1	1	2	1	2	1	1	5	6	1	1	5	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr12:78400845C>A	uc001syp.2	+	8	1700	c.1527C>A	c.(1525-1527)GGC>GGA	p.G509G	NAV3_uc001syo.2_Silent_p.G509G	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	509						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCCCTAAGGGCAGCAAGACAA	0.423										HNSCC(70;0.22)			14	40					7.93312e-07	8.41102e-07	1	0	A	78400845	A	A	78400845	2	1	183	1	0	0	0	0	0	0	0	1	10238	697	25	4		4	NAV3	12	78400845	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08	9136685	78400845	55451050	46	34248											
RNASE13	440163	broad.mit.edu	37	chr14	21502302	21502302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaccattacaatagcccCggaaaccctttgggtagtta	12	10	8	11	1	1	1	1	0	0	1	1	2	1	2	4	2	3	2	4	2	6	5	rs146892669	by1000genomes	TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr14:21502302C>T	uc001vzj.2	-	2	284	c.146G>A	c.(145-147)CGG>CAG	p.R49Q	NDRG2_uc010tll.1_Intron	NM_001012264	NP_001012264	Q5GAN3	RNS13_HUMAN	ribonuclease, RNase A family, 13 precursor	49						extracellular region	nucleic acid binding|pancreatic ribonuclease activity	p.R49Q(1)		upper_aerodigestive_tract(1)	1	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.019)		ACAATAGCCCCGGAAACCCTT	0.468													78	44					0	0	0	0	T	21502302	T	T	21502302	3	4	183	1	0	0	0	0	1	0	0	0	13468	652	23	1	328	1	RNASE13	14	21502302	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08		21502302	85847238	47	34249											
FSCB	84075	broad.mit.edu	37	chr14	44975348	44975348	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcagcaggtctgggctcCgctttagcagtggcctcttc	4	13	11	13	1	4	0	1	0	3	0	6	0	5	0	2	3	2	4	2	3	1	4			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr14:44975348C>T	uc001wvn.2	-	1	1152	c.843G>A	c.(841-843)GCG>GCA	p.A281A		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	281						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		GTCTGGGCTCCGCTTTAGCAG	0.478													18	40					0	0	0	0	T	44975348	T	T	44975348	2	4	183	1	0	0	0	0	0	0	0	1	6100	639	23	1		1	FSCB	14	44975348	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08	23473046	44975348	62374192	48	34250											
AHSA1	10598	broad.mit.edu	37	chr14	77926055	77926055	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaggcaagtgtgaggtgacGgaagtgagtaagcttgatgg	12	8	18	3	1	0	4	0	4	0	0	0	6	0	5	0	4	1	3	0	4	4	2	rs146186794	byFrequency	TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr14:77926055G>A	uc001xtw.2	+	2	337	c.177G>A	c.(175-177)ACG>ACA	p.T59T	VIPAR_uc001xtt.1_5'Flank|VIPAR_uc001xtu.1_5'Flank|VIPAR_uc010tvj.1_5'Flank|VIPAR_uc001xtv.1_5'Flank|AHSA1_uc010tvk.1_Silent_p.T59T	NM_012111	NP_036243	O95433	AHSA1_HUMAN	activator of heat shock 90kDa protein ATPase	59					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		GTGAGGTGACGGAAGTGAGTA	0.448													74	56					0	0	0	0	A	77926055	A	A	77926055	2	1	183	1	0	0	0	0	0	0	0	1	418	1103	39	1		1	AHSA1	14	77926055	Silent	SNP	G	TCGA-CV-5973-01A-11D-1683-08	32950707	77926055	29423485	49	34251											
CDC42BPB	9578	broad.mit.edu	37	chr14	103452874	103452875	+	In_Frame_Ins	INS	-	TCA	TCA																															ccaaagtcagccaggcggatINSatgaccattcacgtccaaaa																										TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr14:103452874_103452875insTCA	uc001ymi.1	-	6	871_872	c.639_640insTGA	c.(637-642)insTGA	p.213_214ins*		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	213_214	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GCCAGGCGGATATGACCATTCA	0.376													---	---	---								TCA	103452875	TCA	TCA	103452874	7	5	183	1	0	1	1	0	0	0	0	0	3088	1406	49	0	4623	0	CDC42BPB	14	103452874	In_Frame_Ins	INS	-	TCGA-CV-5973-01A-11D-1683-08	25526819	103452874	3896666	50	34252											
TLN2	83660	broad.mit.edu	37	chr15	63054621	63054621	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacattcccatacagtgtccGactccatcaagagtctcatc	11	10	6	14	1	2	1	2	0	1	1	7	3	5	1	3	0	1	0	3	0	2	2			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr15:63054621G>A	uc002alb.3	+	36	4930	c.4930G>A	c.(4930-4932)GAC>AAC	p.D1644N	TLN2_uc002alc.3_Missense_Mutation_p.D37N|TLN2_uc002ald.2_Missense_Mutation_p.D37N	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1644					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton	p.D1644N(1)		ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TACAGTGTCCGACTCCATCAA	0.557													39	91					0	0	0	0	A	63054621	A	A	63054621	3	1	183	1	0	0	0	0	1	0	0	0	16014	1058	37	1	5072	1	TLN2	15	63054621	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08		63054621	39476771	51	34253											
HEXA	3073	broad.mit.edu	37	chr15	72641550	72641550	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggattcactggtccaaaggTgccagagggctcagacccag	10	6	14	11	0	2	2	2	0	0	2	3	3	3	3	3	4	1	1	3	4	1	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr15:72641550T>C	uc002aun.3	-	8	1063	c.856A>G	c.(856-858)ACC>GCC	p.T286A	uc002aug.2_Intron|CELF6_uc002auk.3_Intron|HEXA_uc010ukn.1_Missense_Mutation_p.T297A|HEXA_uc002auo.3_Missense_Mutation_p.T149A|HEXA_uc010bix.2_Missense_Mutation_p.T286A|HEXA_uc010biy.2_Missense_Mutation_p.T149A|HEXA_uc010uko.1_Missense_Mutation_p.T112A|HEXA_uc010biz.1_RNA	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	286					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity	p.T286A(1)		ovary(3)|upper_aerodigestive_tract(1)	4						GGTCCAAAGGTGCCAGAGGGC	0.443													25	25					0	0	0	0	C	72641550	C	C	72641550	3	2	183	1	0	0	0	0	1	0	0	0	7112	1696	59	5	761	5	HEXA	15	72641550	Missense_Mutation	SNP	T	TCGA-CV-5973-01A-11D-1683-08	9586929	72641550	29889842	52	34254											
IRX6	79190	broad.mit.edu	37	chr16	55360387	55360387	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgctgggcagtgcgcgacCggagctgggcgccgccttgg	4	6	18	13	5	0	0	0	0	0	0	0	2	0	1	3	4	3	3	3	4	0	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr16:55360387C>T	uc002ehy.2	+	2	718	c.185C>T	c.(184-186)CCG>CTG	p.P62L	IRX6_uc002ehx.2_Missense_Mutation_p.P62L|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	62						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						AGTGCGCGACCGGAGCTGGGC	0.667													7	23					0	0	0	0	T	55360387	T	T	55360387	3	4	183	1	0	0	0	0	1	0	0	0	7887	652	23	1	191	1	IRX6	16	55360387	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08		55360387	34994366	53	34255											
PRSS54	221191	broad.mit.edu	37	chr16	58324903	58324903	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatgctgaggacccagaactCgctcaggatgcagccgaaag	12	5	13	11	2	1	2	1	1	0	1	2	6	1	4	2	2	4	3	2	2	2	0	rs142664927	byFrequency	TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr16:58324903C>T	uc002enf.2	-	4	618	c.223G>A	c.(223-225)GAG>AAG	p.E75K	PRSS54_uc002eng.2_Missense_Mutation_p.E75K|PRSS54_uc010vie.1_Intron	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	75	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.E75K(1)		upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ACCCAGAACTCGCTCAGGATG	0.647													15	54					0	0	0	0	T	58324903	T	T	58324903	3	4	183	1	0	0	0	0	1	0	0	0	12695	893	31	1	980	1	PRSS54	16	58324903	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	2964516	58324903	32029850	54	34256											
HYDIN	54768	broad.mit.edu	37	chr16	71025263	71025263	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcgtttttcttagttctttTtcttcaggcctggcatcttc	3	22	6	10	1	5	0	1	0	4	0	7	0	5	0	1	2	0	3	1	2	1	9			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr16:71025263T>C	uc002ezr.2	-	25	3950	c.3822A>G	c.(3820-3822)GAA>GAG	p.E1274E		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1274										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TTAGTTCTTTTTCTTCAGGCC	0.468													23	28					0	0	0	0	C	71025263	C	C	71025263	2	2	183	1	0	0	0	0	0	0	0	1	7506	1838	64	5		5	HYDIN	16	71025263	Silent	SNP	T	TCGA-CV-5973-01A-11D-1683-08	12700360	71025263	19329490	55	34257											
CENPBD1	92806	broad.mit.edu	37	chr16	90038224	90038224	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgactgagcttctcacccGcttcaaatcgtcgtaacact	9	12	6	14	3	3	2	2	2	2	0	6	2	3	2	1	0	2	3	1	0	2	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr16:90038224G>A	uc002fpr.2	-	1	719	c.107C>T	c.(106-108)GCG>GTG	p.A36V	AFG3L1_uc002fps.1_5'Flank|AFG3L1_uc002fpt.1_5'Flank|AFG3L1_uc002fpu.1_5'Flank|AFG3L1_uc002fpv.1_5'Flank|AFG3L1_uc002fpw.1_5'Flank|AFG3L1_uc002fpx.1_5'Flank	NM_145039	NP_659476	B2RD01	CENP1_HUMAN	CENPB DNA-binding domains containing 1	36	HTH psq-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CTTCTCACCCGCTTCAAATCG	0.468													12	25					0	0	0	0	A	90038224	A	A	90038224	3	1	183	1	0	0	0	0	1	0	0	0	3243	1087	38	1	460	1	CENPBD1	16	90038224	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	19012961	90038224	316529	56	34258											
KIAA0664	23277	broad.mit.edu	37	chr17	2598736	2598736	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcaccttgcccaggtagcGcatgttgatgccccgctggc	6	8	12	15	2	0	1	0	1	0	0	0	1	0	1	4	2	4	5	4	2	1	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr17:2598736G>A	uc002fuy.1	-	14	2445	c.2359C>T	c.(2359-2361)CGC>TGC	p.R787C	KIAA0664_uc002fux.1_Missense_Mutation_p.R720C|KIAA0664_uc010ckc.1_5'Flank	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	787							binding			breast(2)	2						CCCAGGTAGCGCATGTTGATG	0.697													18	41					0	0	0	0	A	2598736	A	A	2598736	3	1	183	1	0	0	0	0	1	0	0	0	8228	1087	38	1	1622	1	KIAA0664	17	2598736	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08		2598736	78596474	57	34259											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	5	11	9	16	2	3	0	0	0	3	0	7	1	5	1	3	3	1	1	3	3	0	2	rs28934574		TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	4					0	0	0	0	A	7577094	A	A	7577094	3	1	183	1	0	0	0	0	1	0	0	0	16448	1115	39	1	442	1	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	4978358	7577094	73618116	58	34260											
HSF5	124535	broad.mit.edu	37	chr17	56536136	56536136	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caataatccttaccaggggaCtttccttgttgtgagttgct	8	15	9	9	0	0	1	0	1	0	0	2	2	2	2	3	2	2	3	3	2	3	6			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr17:56536136C>T	uc002iwi.1	-	5	1837	c.1713G>A	c.(1711-1713)AAG>AAA	p.K571K		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	571						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TACCAGGGGACTTTCCTTGTT	0.418													16	28					0	0	0	0	T	56536136	T	T	56536136	2	4	183	1	0	0	0	0	0	0	0	1	7438	564	20	4		4	HSF5	17	56536136	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08	48959042	56536136	24659074	59	34261											
KIAA1468	57614	broad.mit.edu	37	chr18	59928798	59928798	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acatgtatctttctgccttgCagtccttgatcccatctctc	6	16	5	14	0	3	1	0	1	3	0	7	1	5	1	3	0	2	2	3	0	1	4			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr18:59928798C>A	uc002lil.2	+	16	2472	c.2257C>A	c.(2257-2259)CAG>AAG	p.Q753K	KIAA1468_uc002lik.1_Missense_Mutation_p.Q753K|KIAA1468_uc010xel.1_Missense_Mutation_p.Q753K|KIAA1468_uc002lim.2_Missense_Mutation_p.Q397K	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	753							binding	p.Q753K(1)		ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				TTCTGCCTTGCAGTCCTTGAT	0.433													10	36					3.86212e-05	4.04603e-05	1	0	A	59928798	A	A	59928798	3	1	183	1	0	0	0	0	1	0	0	0	8275	711	25	4	2319	4	KIAA1468	18	59928798	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08		59928798	18148450	60	34262											
ZNF560	147741	broad.mit.edu	37	chr19	9579792	9579792	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taatcttaccaactgtatccCatttaatgtttttaaacaaa	15	16	2	8	0	1	0	0	0	1	0	2	0	2	0	2	0	3	2	2	0	8	8			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr19:9579792C>A	uc002mlp.1	-	9	811	c.601G>T	c.(601-603)GGG>TGG	p.G201W	ZNF560_uc010dwr.1_Missense_Mutation_p.G95W	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						AACTGTATCCCATTTAATGTT	0.294													3	14					0.004672	0.00483689	1	0	A	9579792	A	A	9579792	3	1	183	1	0	0	0	0	1	0	0	0	18058	594	21	4	1779	4	ZNF560	19	9579792	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08		9579792	49549191	61	34263											
HOMER3	9454	broad.mit.edu	37	chr19	19043825	19043825	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtttttcctcgccggggccGttggcactgacgagagggct	5	10	15	11	4	0	2	0	1	0	1	2	3	1	2	3	4	0	4	3	4	0	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr19:19043825G>A	uc002nku.2	-	5	1094	c.441C>T	c.(439-441)AAC>AAT	p.N147N	HOMER3_uc002nko.1_RNA|HOMER3_uc002nkp.1_RNA|HOMER3_uc010eby.2_Silent_p.N111N|HOMER3_uc010ebz.2_Silent_p.N147N|HOMER3_uc002nkw.2_Silent_p.N147N|HOMER3_uc002nkv.2_Silent_p.N147N	NM_004838	NP_004829	Q9NSC5	HOME3_HUMAN	Homer, neuronal immediate early gene, 3 isoform	147					metabotropic glutamate receptor signaling pathway|protein targeting	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	protein binding				0			Epithelial(12;0.0107)			CGCCGGGGCCGTTGGCACTGA	0.587													26	79					0	0	0	0	A	19043825	A	A	19043825	2	1	183	1	0	0	0	0	0	0	0	1	7319	1136	40	1		1	HOMER3	19	19043825	Silent	SNP	G	TCGA-CV-5973-01A-11D-1683-08	9464033	19043825	40085158	62	34264											
ZNF99	7652	broad.mit.edu	37	chr19	22942355	22942355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatcttaccctcattgacaCtttcacaatcttttcttaat	10	17	2	12	0	5	1	2	1	3	0	5	1	5	1	1	0	1	1	1	0	3	6			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr19:22942355C>T	uc010xrh.1	-	4	419	c.419G>A	c.(418-420)AGT>AAT	p.S140N		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CTCATTGACACTTTCACAATC	0.328													9	42					0	0	0	0	T	22942355	T	T	22942355	3	4	183	1	0	0	0	0	1	0	0	0	18271	565	20	4	2709	4	ZNF99	19	22942355	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	3898530	22942355	36186628	63	34265											
PLA2G4C	8605	broad.mit.edu	37	chr19	48578033	48578033	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acacatggtacctttcctttCggggtcctcatggggctgct	5	13	11	12	1	1	0	1	0	0	0	4	0	3	0	3	5	2	3	3	5	1	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr19:48578033C>T	uc002phx.2	-	12	1395	c.997G>A	c.(997-999)GAA>AAA	p.E333K	PLA2G4C_uc002phw.2_Missense_Mutation_p.E268K|PLA2G4C_uc010elr.2_Missense_Mutation_p.E333K|PLA2G4C_uc010xzd.1_Missense_Mutation_p.E343K	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	333	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CCTTTCCTTTCGGGGTCCTCA	0.562													39	125					0	0	0	0	T	48578033	T	T	48578033	3	4	183	1	0	0	0	0	1	0	0	0	12058	893	31	1	656	1	PLA2G4C	19	48578033	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	25635678	48578033	10550950	64	34266											
ZNF816A	125893	broad.mit.edu	37	chr19	53453768	53453768	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttgtatgatccctctccAgtatgaatcttcctatgtct	8	17	5	11	0	3	2	0	2	3	0	6	2	5	2	3	0	0	2	3	0	4	5			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr19:53453768A>T	uc002qal.1	-	5	1561	c.1260T>A	c.(1258-1260)ACT>ACA	p.T420T	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Silent_p.T404T	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	420					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		ATCCCTCTCCAGTATGAATCT	0.388													50	38					0	0	0	0	T	53453768	T	T	53453768	2	4	183	1	0	0	0	0	0	0	0	1	18244	175	7	5		5	ZNF816A	19	53453768	Silent	SNP	A	TCGA-CV-5973-01A-11D-1683-08	4875735	53453768	5675215	65	34267											
ZNF304	57343	broad.mit.edu	37	chr19	57865177	57865177	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcacagagattcctgtacCgtgatgtgatgctggagaac	11	9	13	8	1	0	4	0	2	0	2	1	6	1	4	2	2	3	3	2	2	2	2			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr19:57865177C>T	uc010ygw.1	+	2	506	c.118C>T	c.(118-120)CGT>TGT	p.R40C	ZNF304_uc010etw.2_Missense_Mutation_p.R40C|ZNF304_uc010etx.2_5'UTR	NM_020657	NP_065708	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	40	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		ATTCCTGTACCGTGATGTGAT	0.378													10	65					0	0	0	0	T	57865177	T	T	57865177	3	4	183	1	0	0	0	0	1	0	0	0	17900	652	23	1	124	1	ZNF304	19	57865177	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08	4411409	57865177	1263806	66	34268											
PAX1	5075	broad.mit.edu	37	chr20	21695343	21695343	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccggcccgcggggtgcaCgcccagccagcccccaggcc	4	2	15	20	4	0	0	0	0	0	0	0	0	0	0	7	4	4	1	7	4	0	0			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr20:21695343C>T	uc002wsj.2	+	5	1561	c.1507C>T	c.(1507-1509)CGC>TGC	p.R503C	PAX1_uc010zsl.1_3'UTR|PAX1_uc010zsm.1_3'UTR	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	503					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						GCGGGGTGCACGCCCAGCCAG	0.682													5	22					0	0	0	0	T	21695343	T	T	21695343	3	4	183	1	0	0	0	0	1	0	0	0	11532	536	19	1	1525	1	PAX1	20	21695343	Missense_Mutation	SNP	C	TCGA-CV-5973-01A-11D-1683-08		21695343	41330177	67	34269											
SRMS	6725	broad.mit.edu	37	chr20	62178692	62178692	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaggctcggcggggagcgtgGgcactgggtcagtgttgggg	5	7	22	7	3	1	0	1	0	0	0	2	1	1	1	0	8	1	3	0	8	1	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr20:62178692G>A	uc002yfi.1	-	1	166	c.125C>T	c.(124-126)CCC>CTC	p.P42L		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	42							ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GGGGAGCGTGGGCACTGGGTC	0.697													72	259					0	0	0	0	A	62178692	A	A	62178692	3	1	183	1	0	0	0	0	1	0	0	0	15218	1232	43	4	1373	4	SRMS	20	62178692	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	40483349	62178692	846828	68	34270											
C2CD2	25966	broad.mit.edu	37	chr21	43327154	43327154	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcgaggcttggtcttcacaGcagtgacagtagtgaccaca	10	8	12	11	2	2	2	1	2	1	0	2	3	2	2	1	2	1	3	1	2	1	3			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr21:43327154G>A	uc002yzw.2	-	10	1507	c.1265C>T	c.(1264-1266)GCT>GTT	p.A422V	C2CD2_uc002yzt.2_Missense_Mutation_p.A38V|C2CD2_uc002yzu.2_Missense_Mutation_p.A254V|C2CD2_uc002yzv.2_Missense_Mutation_p.A267V|C2CD2_uc002yzx.1_Missense_Mutation_p.A267V	NM_015500	NP_056315	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2 isoform	422						cytosol|extracellular region|nucleus				ovary(1)	1						GGTCTTCACAGCAGTGACAGT	0.582													15	27					0	0	0	0	A	43327154	A	A	43327154	3	1	183	1	0	0	0	0	1	0	0	0	2162	971	34	4	845	4	C2CD2	21	43327154	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08		43327154	4802741	69	34271											
XKR3	150165	broad.mit.edu	37	chr22	17288926	17288926	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgaagatgaaactcctcctGtgctttcttcatccatctct	8	15	5	13	1	3	2	1	1	2	1	8	3	6	2	3	0	2	1	3	0	2	2			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr22:17288926G>T	uc002zlv.2	-	2	136	c.38C>A	c.(37-39)ACA>AAA	p.T13K	XKR3_uc011agf.1_Missense_Mutation_p.T13K	NM_175878	NP_787074	Q5GH77	XKR3_HUMAN	X Kell blood group precursor-related family,	13						integral to membrane|plasma membrane				large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AACTCCTCCTGTGCTTTCTTC	0.408													21	48					1.55795e-14	1.71374e-14	1	0	T	17288926	T	T	17288926	3	4	183	1	0	0	0	0	1	0	0	0	17500	1377	48	4	1353	4	XKR3	22	17288926	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08		17288926	34015640	70	34272											
SEC14L2	23541	broad.mit.edu	37	chr22	30803469	30803469	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatggctgcccagtctggtaCgacataattggacctctgga	9	10	12	10	1	2	0	0	0	2	0	2	4	2	2	2	4	2	2	2	4	2	3	rs144595900	byFrequency	TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr22:30803469C>T	uc003ahr.2	+	5	473	c.300C>T	c.(298-300)TAC>TAT	p.Y100Y	SEC14L2_uc003ahq.2_Silent_p.Y100Y|SEC14L2_uc011akx.1_Silent_p.Y46Y|SEC14L2_uc003ahs.2_Silent_p.Y26Y|SEC14L2_uc011aky.1_Intron|SEC14L2_uc003aht.2_5'Flank|SEC14L2_uc003ahu.3_5'Flank|SEC14L2_uc010gvv.2_5'Flank|SEC14L2_uc010gvw.1_5'Flank|MTP18_uc010gvx.1_5'Flank|MTP18_uc003ahv.1_5'Flank|MTP18_uc010gvy.1_5'Flank	NM_012429	NP_036561	O76054	S14L2_HUMAN	SEC14-like 2 isoform 1	100	CRAL-TRIO.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	phospholipid binding|transporter activity|vitamin E binding				0					Vitamin E(DB00163)	CAGTCTGGTACGACATAATTG	0.557													40	82					0	0	0	0	T	30803469	T	T	30803469	2	4	183	1	0	0	0	0	0	0	0	1	14047	547	19	1		1	SEC14L2	22	30803469	Silent	SNP	C	TCGA-CV-5973-01A-11D-1683-08	13514543	30803469	20501097	71	34273											
PLXNB2	23654	broad.mit.edu	37	chr22	50720458	50720458	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctcctcaggcacagccgggGacaggaagacgaccttggtg	9	5	15	12	2	1	1	1	0	0	1	2	4	2	3	3	5	1	2	3	5	1	1			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chr22:50720458G>A	uc003bkv.3	-	20	3276	c.3170C>T	c.(3169-3171)TCC>TTC	p.S1057F	PLXNB2_uc003bkt.1_5'UTR|PLXNB2_uc003bku.1_Missense_Mutation_p.S42F	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1057	IPT/TIG 3.|Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CACAGCCGGGGACAGGAAGAC	0.647													7	21					0	0	0	0	A	50720458	A	A	50720458	3	1	183	1	0	0	0	0	1	0	0	0	12179	1174	41	2	2418	2	PLXNB2	22	50720458	Missense_Mutation	SNP	G	TCGA-CV-5973-01A-11D-1683-08	19916989	50720458	584108	72	34274											
RGAG4	340526	broad.mit.edu	37	chrX	71350464	71350464	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttgggaacgcgcactttTctttctatctccacacattc	7	14	7	13	2	3	0	0	0	3	0	5	1	3	1	1	2	1	2	1	2	2	6			TCGA-CV-5973-01A-11D-1683-08	TCGA-CV-5973-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	b848fbad-1eb3-4bc2-9006-2d0ca559cee8	1c5d37a1-9387-42cb-9d2f-623b97247fad	g.chrX:71350464T>G	uc010nlh.1	-	1	1288	c.927A>C	c.(925-927)AGA>AGC	p.R309S	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	309										ovary(2)|skin(1)	3	Renal(35;0.156)					CGCGCACTTTTCTTTCTATCT	0.483													40	74					0	0	0	0	G	71350464	G	G	71350464	3	3	183	1	0	0	0	0	1	0	0	0	13340	1780	62	5	786	5	RGAG4	23	71350464	Missense_Mutation	SNP	T	TCGA-CV-5973-01A-11D-1683-08		71350464	83920096	73	34275											
PRDM2	7799	broad.mit.edu	37	chr1	14106924	14106924	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcctacgtgtagtgctgtAaagaaaaggaaaccaaccac	16	6	9	10	1	0	1	0	0	0	1	0	2	0	2	3	1	5	3	3	1	8	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:14106924A>G	uc001avi.2	+	8	3490	c.2634A>G	c.(2632-2634)GTA>GTG	p.V878V	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Silent_p.V878V|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Silent_p.V677V|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	878						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GTAGTGCTGTAAAGAAAAGGA	0.423													26	68					0	0	0	0	G	14106924	G	G	14106924	2	3	184	1	0	0	0	0	0	0	0	1	12520	349	13	5		5	PRDM2	1	14106924	Silent	SNP	A	TCGA-CV-5976-01A-11D-1683-08		14106924	235143697	1	34276											
PDIK1L	149420	broad.mit.edu	37	chr1	26448944	26448944	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtgaagaaaaaatctatgaAtgggcgaatgaaacaactga	19	8	10	4	1	1	5	0	4	1	1	1	6	1	5	0	1	2	0	0	1	9	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:26448944A>G	uc010oew.1	+	3	1175	c.902A>G	c.(901-903)AAT>AGT	p.N301S	PDIK1L_uc001blj.3_Missense_Mutation_p.N301S|PDIK1L_uc009vsb.2_Missense_Mutation_p.N301S	NM_152835	NP_690048	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	301	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity				0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		AAATCTATGAATGGGCGAATG	0.398													21	45					0	0	0	0	G	26448944	G	G	26448944	3	3	184	1	0	0	0	0	1	0	0	0	11727	101	4	5	908	5	PDIK1L	1	26448944	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	12342020	26448944	222801677	2	34277											
MAP3K6	9064	broad.mit.edu	37	chr1	27682581	27682581	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaccaggccctggtccgttGaaagagcagctgtcaagaag	11	6	13	11	1	1	3	1	1	0	2	2	3	2	3	3	2	2	4	3	2	3	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:27682581G>C	uc001bny.1	-	27	3896	c.3647C>G	c.(3646-3648)TCA>TGA	p.S1216*	MAP3K6_uc009vsw.1_Nonsense_Mutation_p.S1208*	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	1216					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CTGGTCCGTTGAAAGAGCAGC	0.562													14	41					0	0	0	0	C	27682581	C	C	27682581	4	2	184	1	0	0	0	0	0	1	0	0	9307	1294	45	2	231	2	MAP3K6	1	27682581	Nonsense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	1233637	27682581	221568040	3	34278											
EPHA10	284656	broad.mit.edu	37	chr1	38227606	38227606	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctgcagtcacggagtgtGaactgcagttccacgaagat	10	9	12	10	2	1	2	1	1	0	1	2	4	2	3	1	1	4	4	1	1	2	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:38227606G>A	uc009vvi.2	-	3	407	c.321C>T	c.(319-321)TTC>TTT	p.F107F	EPHA10_uc001cbw.3_Silent_p.F107F	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	107	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CACGGAGTGTGAACTGCAGTT	0.622													41	101					0	0	0	0	A	38227606	A	A	38227606	2	1	184	1	0	0	0	0	0	0	0	1	5190	1281	45	2		2	EPHA10	1	38227606	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08	10545025	38227606	211023015	4	34279											
FPGT	8790	broad.mit.edu	37	chr1	74671407	74671407	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcattcagcctgaatagctAtaagttgctgtccattgaag	12	12	9	8	0	1	2	1	2	0	0	2	2	2	2	2	0	4	4	2	0	5	6			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:74671407A>G	uc001dgb.1	+	4	1713	c.1676A>G	c.(1675-1677)TAT>TGT	p.Y559C	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Missense_Mutation_p.Y184C|FPGT_uc010oqu.1_Missense_Mutation_p.Y305C|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	559					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						CTGAATAGCTATAAGTTGCTG	0.338													17	43					0	0	0	0	G	74671407	G	G	74671407	3	3	184	1	0	0	0	0	1	0	0	0	6071	449	16	5	1690	5	FPGT	1	74671407	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	36443801	74671407	174579214	5	34280											
CCDC76	54482	broad.mit.edu	37	chr1	100598746	100598746	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcgacctccgcgacgtcgCcgcacgcgcctggttttcca	4	8	12	17	8	0	0	0	0	0	0	3	2	2	0	5	2	0	2	5	2	0	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:100598746C>A	uc001dsv.2	+	1	41	c.22C>A	c.(22-24)CCG>ACG	p.P8T	SASS6_uc001dsu.2_5'Flank|SASS6_uc009wdz.2_5'Flank|CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Missense_Mutation_p.P8T	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	8					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		CGCGACGTCGCCGCACGCGCC	0.552													8	33					0.000274275	0.000292052	1	0	A	100598746	A	A	100598746	3	1	184	1	0	0	0	0	1	0	0	0	2863	739	26	4	24	4	CCDC76	1	100598746	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	25927339	100598746	148651875	6	34281											
SYPL2	284612	broad.mit.edu	37	chr1	110022065	110022065	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtgttcaaggagaccccGtggcatggacagggccaggg	8	8	16	9	1	1	1	1	0	0	1	1	3	1	2	3	5	0	2	3	5	1	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:110022065G>C	uc001dxp.2	+	6	1080	c.714G>C	c.(712-714)CCG>CCC	p.P238P	SYPL2_uc010ovk.1_Silent_p.P174P	NM_001040709	NP_001035799	Q5VXT5	SYPL2_HUMAN	mitsugumin 29	238	Cytoplasmic (Potential).|MARVEL.					integral to membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		AGGAGACCCCGTGGCATGGAc	0.413													22	51					0	0	0	0	C	110022065	C	C	110022065	2	2	184	1	0	0	0	0	0	0	0	1	15529	1132	40	3		3	SYPL2	1	110022065	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08	9423319	110022065	139228556	7	34282											
MOV10	4343	broad.mit.edu	37	chr1	113240920	113240920	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgtccagggctttcccatCatctttcacggcgtaatggg	7	12	10	12	2	3	0	2	0	1	0	5	0	5	0	2	3	0	2	2	3	1	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:113240920C>T	uc001eck.2	+	16	2598	c.2328C>T	c.(2326-2328)ATC>ATT	p.I776I	MOV10_uc001ecl.2_Intron|MOV10_uc001ecn.2_Silent_p.I776I|MOV10_uc001ecm.2_Silent_p.I716I	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	776					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		GCTTTCCCATCATCTTTCACG	0.557													7	28					0	0	0	0	T	113240920	T	T	113240920	2	4	184	1	0	0	0	0	0	0	0	1	9771	816	29	2		2	MOV10	1	113240920	Silent	SNP	C	TCGA-CV-5976-01A-11D-1683-08	3218855	113240920	136009701	8	34283											
NBPF10	100132406	broad.mit.edu	37	chr1	145299900	145299900	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagagaaatgttttctaactCaactgtccggcttcctggcc	10	12	8	11	1	2	1	1	0	1	1	4	2	4	1	3	2	2	2	3	2	4	4			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:145299900C>G	uc001end.3	+	6	984	c.949C>G	c.(949-951)CAA>GAA	p.Q317E	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.Q317E|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	317											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTTTCTAACTCAACTGTCCGG	0.428													22	134					0	0	0	0	G	145299900	G	G	145299900	3	3	184	1	0	0	0	0	1	0	0	0	10246	827	29	2	971	2	NBPF10	1	145299900	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	32058980	145299900	103950721	9	34284											
POLR3C	10623	broad.mit.edu	37	chr1	145608112	145608113	+	Frame_Shift_Ins	INS	-	A	A																															gttaaaattccttacctatcINSaagctgagtttaggaaccag																										TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:145608112_145608113insA	uc001eoh.2	-	4	745_746	c.584_585insT	c.(583-585)TTGfs	p.L195fs	NBPF10_uc001emp.3_Intron|RNF115_uc001eoj.2_5'Flank|RNF115_uc001eok.2_5'Flank|RNF115_uc009wiy.2_5'Flank|POLR3C_uc001eog.2_Frame_Shift_Ins_p.L208fs|POLR3C_uc001eoi.2_RNA|POLR3C_uc009wix.2_Frame_Shift_Ins_p.L195fs	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	195					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			CCTTACCTATCAAGCTGAGTTT	0.411													---	---	---								A	145608113	A	A	145608112	7	5	184	1	0	1	1	0	0	0	0	0	12285	825	29	0	1067	0	POLR3C	1	145608112	Frame_Shift_Ins	INS	-	TCGA-CV-5976-01A-11D-1683-08	308212	145608112	103642509	10	34285											
HRNR	388697	broad.mit.edu	37	chr1	152192700	152192700	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggaatgctctgagctagactCgtggtgaccaaagccagaag	12	7	13	9	1	1	4	0	2	1	2	2	5	1	5	2	2	3	2	2	2	4	1	rs147754674		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:152192700C>G	uc001ezt.1	-	3	1481	c.1405G>C	c.(1405-1407)GAG>CAG	p.E469Q		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	469					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCTAGACTCGTGGTGACCA	0.567													42	109					0	0	0	0	G	152192700	G	G	152192700	3	3	184	1	0	0	0	0	1	0	0	0	7398	893	31	3	7151	3	HRNR	1	152192700	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	6584588	152192700	97057921	11	34286											
HRNR	388697	broad.mit.edu	37	chr1	152192821	152192821	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccctgacccagacccacgCtggccgtggcctggagactg	6	6	13	16	2	0	3	0	1	0	2	0	4	0	3	5	3	1	1	5	3	0	0			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:152192821C>G	uc001ezt.1	-	3	1360	c.1284G>C	c.(1282-1284)CAG>CAC	p.Q428H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	428	4.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGACCCACGCTGGCCGTGGC	0.612													18	44					0	0	0	0	G	152192821	G	G	152192821	3	3	184	1	0	0	0	0	1	0	0	0	7398	796	28	4	7272	4	HRNR	1	152192821	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	121	152192821	97057800	12	34287											
FCRLB	127943	broad.mit.edu	37	chr1	161697075	161697075	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctccaccaccgccccagctCcatgggccgcagccttggct	5	6	9	21	2	0	0	0	0	0	0	2	0	2	0	9	2	2	3	9	2	0	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:161697075C>A	uc001gbh.2	+	8	1138	c.904C>A	c.(904-906)CCA>ACA	p.P302T	FCRLB_uc009wus.2_Missense_Mutation_p.P302T|FCRLB_uc001gbj.2_Silent_p.L253L|FCRLB_uc001gbk.2_Missense_Mutation_p.S267Y|FCRLB_uc001gbl.2_Silent_p.L246L|FCRLB_uc001gbm.2_Missense_Mutation_p.S260Y|FCRLB_uc001gbi.2_Missense_Mutation_p.P302T|FCRLB_uc001gbn.3_Missense_Mutation_p.S304Y	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	302						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CGCCCCAGCTCCATGGGCCGC	0.637													11	36					0.000673444	0.000697712	1	0	A	161697075	A	A	161697075	3	1	184	1	0	0	0	0	1	0	0	0	5833	855	30	2	926	2	FCRLB	1	161697075	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	9504254	161697075	87553546	13	34288											
FCRLB	127943	broad.mit.edu	37	chr1	161697178	161697178	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccgtccggaacaccacctCcaccgggctgcagttcccgg	6	6	10	19	4	0	0	0	0	0	0	4	1	4	1	7	3	2	3	7	3	1	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:161697178C>T	uc001gbh.2	+	8	1241	c.1007C>T	c.(1006-1008)TCC>TTC	p.S336F	FCRLB_uc009wus.2_Missense_Mutation_p.S336F|FCRLB_uc001gbj.2_Missense_Mutation_p.P288S|FCRLB_uc001gbk.2_3'UTR|FCRLB_uc001gbl.2_Missense_Mutation_p.P281S|FCRLB_uc001gbm.2_3'UTR|FCRLB_uc001gbi.2_Missense_Mutation_p.S336F|FCRLB_uc001gbn.3_3'UTR	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	336						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			AACACCACCTCCACCGGGCTG	0.692													16	30					0	0	0	0	T	161697178	T	T	161697178	3	4	184	1	0	0	0	0	1	0	0	0	5833	855	30	2	1029	2	FCRLB	1	161697178	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	103	161697178	87553443	14	34289											
FAM5B	57795	broad.mit.edu	37	chr1	177249883	177249883	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgcagaagcaggatagccGcattgaggtacactccatct	11	8	11	11	1	1	2	0	1	1	1	2	3	2	3	2	2	4	5	2	2	3	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:177249883G>A	uc001glf.2	+	8	1883	c.1571G>A	c.(1570-1572)CGC>CAC	p.R524H	FAM5B_uc001glg.2_Missense_Mutation_p.R419H	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	524						extracellular region		p.R524H(1)		skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CAGGATAGCCGCATTGAGGTA	0.567													13	22					0	0	0	0	A	177249883	A	A	177249883	3	1	184	1	0	0	0	0	1	0	0	0	5625	1087	38	1	1597	1	FAM5B	1	177249883	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	15552705	177249883	72000738	15	34290											
CACNA1E	777	broad.mit.edu	37	chr1	181701838	181701838	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccctggacaaccagaggacCcctttgtccctgggccagcg	7	6	12	16	1	0	1	0	0	0	1	1	3	1	3	6	3	2	0	6	3	1	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:181701838C>T	uc001gow.2	+	20	2781	c.2616C>T	c.(2614-2616)ACC>ACT	p.T872T	CACNA1E_uc009wxs.2_Silent_p.T760T|CACNA1E_uc001gox.1_Silent_p.T98T|CACNA1E_uc009wxt.2_Silent_p.T98T	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	872	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						ACCAGAGGACCCCTTTGTCCC	0.622													10	14					0	0	0	0	T	181701838	T	T	181701838	2	4	184	1	0	0	0	0	0	0	0	1	2554	610	22	4		4	CACNA1E	1	181701838	Silent	SNP	C	TCGA-CV-5976-01A-11D-1683-08	4451955	181701838	67548783	16	34291											
CR1	1378	broad.mit.edu	37	chr1	207741172	207741172	+	Frame_Shift_Del	DEL	T	-	-																															ttttgtatgttttctagaaaTcttttgtccaagtcctccag																										TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr1:207741172delT	uc001hfy.2	+	17	2746	c.2606delT	c.(2605-2607)ATCfs	p.I869fs	CR1_uc009xcl.1_Frame_Shift_Del_p.I419fs|CR1_uc001hfx.2_Frame_Shift_Del_p.I1319fs|CR1_uc009xck.1_Frame_Shift_Del_p.I419fs	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	869	Extracellular (Potential).|Sushi 14.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TTTCTAGAAATCTTTTGTCCA	0.408													---	---	---								-	207741172	-	-	207741172	7	5	184	1	0	1	0	1	0	0	0	0	3855	1435	50	0	4054	0	CR1	1	207741172	Frame_Shift_Del	DEL	T	TCGA-CV-5976-01A-11D-1683-08	26039334	207741172	41509449	17	34292											
SIX2	10736	broad.mit.edu	37	chr2	45233324	45233324	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttctaggagcccaggtcCacgaggttggctgacatggg	7	8	17	9	1	1	1	0	1	1	0	2	3	2	2	2	6	1	3	2	6	1	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr2:45233324C>T	uc002ruo.2	-	2	1154	c.861G>A	c.(859-861)GTG>GTA	p.V287V	SIX2_uc002rup.2_Silent_p.V289V	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	287						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGCCCAGGTCCACGAGGTTGG	0.642													13	56					0	0	0	0	T	45233324	T	T	45233324	2	4	184	1	0	0	0	0	0	0	0	1	14412	581	21	4		4	SIX2	2	45233324	Silent	SNP	C	TCGA-CV-5976-01A-11D-1683-08		45233324	197966049	18	34293											
APLF	200558	broad.mit.edu	37	chr2	68729908	68729908	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtcttcagagaagagtcagCtcttaccattgaagccaaat	14	10	8	9	0	4	3	2	1	2	2	4	4	4	3	2	0	3	1	2	0	4	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr2:68729908C>T	uc002sep.2	+	3	387	c.214C>T	c.(214-216)CTC>TTC	p.L72F	APLF_uc010fdf.2_Missense_Mutation_p.L48F	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	72	FHA-like.				double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						GAAGAGTCAGCTCTTACCATT	0.294													31	76					0	0	0	0	T	68729908	T	T	68729908	3	4	184	1	0	0	0	0	1	0	0	0	776	797	28	4	224	4	APLF	2	68729908	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	23496584	68729908	174469465	19	34294											
LCT	3938	broad.mit.edu	37	chr2	136546023	136546023	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcacaagagaaaagagaacGtacaaagctgtctgtgcttc	16	7	10	8	1	1	2	0	0	1	2	2	4	1	2	0	0	5	4	0	0	6	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr2:136546023G>A	uc002tuu.1	-	17	5666	c.5655C>T	c.(5653-5655)TAC>TAT	p.Y1885Y		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1885	Helical; (Potential).				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		AAAAGAGAACGTACAAAGCTG	0.522													31	146					0	0	0	0	A	136546023	A	A	136546023	2	1	184	1	0	0	0	0	0	0	0	1	8733	1140	40	1		1	LCT	2	136546023	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08	67816115	136546023	106653350	20	34295											
LRP1B	53353	broad.mit.edu	37	chr2	141946119	141946119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtccacaaaatagagatttCgagtgagccagtcaatcgcc	13	8	10	10	2	1	2	1	1	0	1	4	4	2	2	3	1	1	0	3	1	4	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr2:141946119C>T	uc002tvj.1	-	7	1856	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	295	Extracellular (Potential).|LDL-receptor class B 2.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATAGAGATTTCGAGTGAGCCA	0.408										TSP Lung(27;0.18)			13	26					0	0	0	0	T	141946119	T	T	141946119	3	4	184	1	0	0	0	0	1	0	0	0	9005	884	31	1	13255	1	LRP1B	2	141946119	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	5400096	141946119	101253254	21	34296											
FN1	2335	broad.mit.edu	37	chr2	216298182	216298182	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgtcaaagcaagtctcttCagctgaggggaaaaggaaag	14	8	12	7	0	3	1	2	1	1	0	4	3	3	3	0	3	2	2	0	3	5	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr2:216298182C>T	uc002vfa.2	-	3	546	c.280G>A	c.(280-282)GAA>AAA	p.E94K	FN1_uc002vfb.2_Missense_Mutation_p.E94K|FN1_uc002vfc.2_Missense_Mutation_p.E94K|FN1_uc002vfd.2_Missense_Mutation_p.E94K|FN1_uc002vfe.2_Missense_Mutation_p.E94K|FN1_uc002vff.2_Missense_Mutation_p.E94K|FN1_uc002vfg.2_Missense_Mutation_p.E94K|FN1_uc002vfh.2_Missense_Mutation_p.E94K|FN1_uc002vfi.2_Missense_Mutation_p.E94K|FN1_uc002vfj.2_Missense_Mutation_p.E94K|FN1_uc002vfl.2_Missense_Mutation_p.E94K	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	94	Fibrin- and heparin-binding 1.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAGTCTCTTCAGCTGAGGGG	0.468													10	32					0	0	0	0	T	216298182	T	T	216298182	3	4	184	1	0	0	0	0	1	0	0	0	5994	835	29	2	7362	2	FN1	2	216298182	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	74352063	216298182	26901191	22	34297											
STAB1	23166	broad.mit.edu	37	chr3	52553341	52553341	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgaccatgaggccgtgaacgGcatcctgcacttcattgacc	9	8	10	14	3	1	3	1	3	0	0	2	4	2	3	4	2	2	2	4	2	1	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr3:52553341G>A	uc003dej.2	+	49	5170	c.5096G>A	c.(5095-5097)GGC>GAC	p.G1699D	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1699	Extracellular (Potential).|FAS1 5.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.G1699D(1)		large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCCGTGAACGGCATCCTGCAC	0.642													63	76					0	0	0	0	A	52553341	A	A	52553341	3	1	184	1	0	0	0	0	1	0	0	0	15303	1203	42	4	5290	4	STAB1	3	52553341	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08		52553341	145469089	23	34298											
ARF4	378	broad.mit.edu	37	chr3	57569702	57569702	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccatactgtgaaacaaaTgttcttatattctactgttt	12	17	4	8	0	2	1	0	1	2	0	3	1	3	1	1	0	3	2	1	0	6	7			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr3:57569702T>C	uc003dix.3	-	3	529	c.181A>G	c.(181-183)ATT>GTT	p.I61V	ARF4_uc003diy.3_RNA|ARF4_uc010hnd.2_Missense_Mutation_p.I34V|ARF4_uc003diz.3_Intron	NM_001660	NP_001651	P18085	ARF4_HUMAN	ADP-ribosylation factor 4	61					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus	GTP binding|GTPase activity	p.I61V(1)		upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0449)|Kidney(284;0.0561)		GTGAAACAAATGTTCTTATAT	0.353													26	35					0	0	0	0	C	57569702	C	C	57569702	3	2	184	1	0	0	0	0	1	0	0	0	846	1464	51	5	377	5	ARF4	3	57569702	Missense_Mutation	SNP	T	TCGA-CV-5976-01A-11D-1683-08	5016361	57569702	140452728	24	34299											
GPR149	344758	broad.mit.edu	37	chr3	154055685	154055685	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtatgaggctgtttcccCtaggtcacatgaaacaaatc	12	10	10	9	0	1	2	1	2	0	0	3	3	2	3	2	3	1	3	2	3	4	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr3:154055685C>T	uc003faa.2	-	4	2099	c.1999G>A	c.(1999-2001)GGG>AGG	p.G667R		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	667	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GCTGTTTCCCCTAGGTCACAT	0.438													4	143					0	0	0	0	T	154055685	T	T	154055685	3	4	184	1	0	0	0	0	1	0	0	0	6692	681	24	4	200	4	GPR149	3	154055685	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	96485983	154055685	43966745	25	34300											
KPNA4	3840	broad.mit.edu	37	chr3	160286032	160286032	+	5'Flank	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggagccttctgcagcagcAcaagatggctgggagcaaca	11	6	14	10	0	1	1	0	0	1	1	1	3	1	3	1	3	6	5	1	3	2	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr3:160286032A>G	uc003fdn.2	-						uc003fdp.1_RNA	NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4						NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			CTGCAGCAGCACAAGATGGCT	0.547													42	35					0	0	0	0	G	160286032	G	G	160286032	1	3	184	0	1	0	0	0	0	0	0	0	8471	174	6	5		5	KPNA4	3	160286032	5'Flank	SNP	A	TCGA-CV-5976-01A-11D-1683-08	6230347	160286032	37736398	26	34301											
GABRA4	2557	broad.mit.edu	37	chr4	46930431	46930431	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacttcccagtagcccctatGgtattaactgtggtctttat	9	15	7	10	0	1	0	0	0	1	0	2	0	2	0	3	2	3	2	3	2	6	7			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:46930431G>A	uc003gxg.2	-	9	1615	c.1476C>T	c.(1474-1476)ACC>ACT	p.T492T		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	492	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TAGCCCCTATGGTATTAACTG	0.473													16	77					0	0	0	0	A	46930431	A	A	46930431	2	1	184	1	0	0	0	0	0	0	0	1	6197	1335	47	4		4	GABRA4	4	46930431	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08		46930431	144223845	27	34302											
LPHN3	23284	broad.mit.edu	37	chr4	62598970	62598970	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttacaccctacggatcgAaggaacatgggatactgcat	12	8	9	12	2	0	0	0	0	0	0	1	4	0	3	2	3	5	1	2	3	5	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:62598970A>T	uc010ihh.2	+	5	1066	c.893A>T	c.(892-894)GAA>GTA	p.E298V	LPHN3_uc003hcq.3_Missense_Mutation_p.E298V|LPHN3_uc010ihg.1_Missense_Mutation_p.E366V|LPHN3_uc003hcs.1_Missense_Mutation_p.E127V	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	298	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CTACGGATCGAAGGAACATGG	0.393													8	37					0	0	0	0	T	62598970	T	T	62598970	3	4	184	1	0	0	0	0	1	0	0	0	8967	246	9	5	911	5	LPHN3	4	62598970	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	15668539	62598970	128555306	28	34303											
UGT2B11	10720	broad.mit.edu	37	chr4	70071211	70071211	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgttacctagaaggtcattCtggggtatccacttgtacag	9	13	11	8	0	2	1	1	0	1	1	3	1	3	1	2	3	2	3	2	3	5	6			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:70071211C>G	uc003heh.2	-	4	1086	c.1077G>C	c.(1075-1077)CAG>CAC	p.Q359H	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	359					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						GAAGGTCATTCTGGGGTATCC	0.373													7	127					0	0	0	0	G	70071211	G	G	70071211	3	3	184	1	0	0	0	0	1	0	0	0	17025	912	32	2	524	2	UGT2B11	4	70071211	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	7472241	70071211	121083065	29	34304											
CDS1	1040	broad.mit.edu	37	chr4	85566477	85566477	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtacatcacaagttttataAggtacttttacacttgagac	13	15	6	7	0	1	1	1	1	0	1	1	2	1	1	0	1	3	3	0	1	6	8			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:85566477A>T	uc011ccv.1	+	12	1753	c.1255A>T	c.(1255-1257)AGG>TGG	p.R419W	CDS1_uc010ike.1_3'UTR	NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	419					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		AAGTTTTATAAGGTACTTTTA	0.328													29	30					0	0	0	0	T	85566477	T	T	85566477	3	4	184	1	0	0	0	0	1	0	0	0	3192	86	3	5	1301	5	CDS1	4	85566477	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	15495266	85566477	105587799	30	34305											
ADAM29	11086	broad.mit.edu	37	chr4	175897355	175897355	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agttgctggaggatctatatGttattgttaatatagtggat	11	17	11	2	0	1	0	0	0	1	0	1	3	1	3	0	3	1	4	0	3	6	8			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:175897355G>T	uc003iuc.2	+	5	1349	c.679G>T	c.(679-681)GTT>TTT	p.V227F	ADAM29_uc003iud.2_Missense_Mutation_p.V227F|ADAM29_uc010irr.2_Missense_Mutation_p.V227F|ADAM29_uc011cki.1_Missense_Mutation_p.V227F	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	227	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GGATCTATATGTTATTGTTAA	0.338													23	42					1.10513e-12	1.25832e-12	1	0	T	175897355	T	T	175897355	3	4	184	1	0	0	0	0	1	0	0	0	247	1377	48	4	681	4	ADAM29	4	175897355	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	90330878	175897355	15256921	31	34306											
FAT1	2195	broad.mit.edu	37	chr4	187518254	187518254	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgcagttgcagtgataggagCcgtgcgtgttctcacagagg	8	10	15	8	2	1	2	1	1	1	1	2	3	1	3	1	2	4	4	1	2	1	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr4:187518254C>T	uc003izf.2	-	25	12628	c.12440G>A	c.(12439-12441)GGC>GAC	p.G4147D	FAT1_uc010isn.2_5'Flank|FAT1_uc003ize.2_Missense_Mutation_p.G38D	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4147	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTGATAGGAGCCGTGCGTGTT	0.587										HNSCC(5;0.00058)			9	16					0	0	0	0	T	187518254	T	T	187518254	3	4	184	1	0	0	0	0	1	0	0	0	5721	739	26	4	1338	4	FAT1	4	187518254	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	11620899	187518254	3636022	32	34307											
ANKH	56172	broad.mit.edu	37	chr5	14716914	14716914	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcaagattttctcagacaCgttgggtgtccaaaacatca	13	12	7	9	1	3	2	3	0	1	2	5	2	4	2	1	1	1	1	1	1	4	4	rs148228793		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr5:14716914C>T	uc003jfm.3	-	9	1373	c.1042G>A	c.(1042-1044)GTG>ATG	p.V348M	ANKH_uc003jfl.3_Missense_Mutation_p.V61M	NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	348	Extracellular (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity	p.V348M(1)		upper_aerodigestive_tract(1)	1						TTCTCAGACACGTTGGGTGTC	0.463													8	23					0	0	0	0	T	14716914	T	T	14716914	3	4	184	1	0	0	0	0	1	0	0	0	627	536	19	1	452	1	ANKH	5	14716914	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08		14716914	166198346	33	34308											
HMGCR	3156	broad.mit.edu	37	chr5	74655134	74655134	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctacattgcctgtggacAggtgagctctccagcctcca	8	10	9	14	0	2	1	0	1	2	0	4	2	3	2	4	2	4	1	4	2	1	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr5:74655134A>G	uc003kdp.2	+	17	2453	c.2297A>G	c.(2296-2298)CAG>CGG	p.Q766R	HMGCR_uc011cst.1_Missense_Mutation_p.Q786R|HMGCR_uc003kdq.2_Missense_Mutation_p.Q713R|HMGCR_uc010izo.2_Missense_Mutation_p.Q89R|HMGCR_uc010izp.2_Intron	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	766	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GCCTGTGGACAGGTGAGCTCT	0.453													12	33					0	0	0	0	G	74655134	G	G	74655134	3	3	184	1	0	0	0	0	1	0	0	0	7270	202	7	5	2359	5	HMGCR	5	74655134	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	59938220	74655134	106260126	34	34309											
CDYL	9425	broad.mit.edu	37	chr6	4935984	4935984	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttatccacaaagtcctcagaGaataactcactaaatccaga	17	9	4	11	0	2	2	2	0	0	2	5	3	5	2	3	0	1	0	3	0	6	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:4935984G>A	uc003mwi.2	+	5	1220	c.1089G>A	c.(1087-1089)GAG>GAA	p.E363E	CDYL_uc003mwj.2_Silent_p.E309E|CDYL_uc003mwk.2_Silent_p.E74E|CDYL_uc011dhx.1_Silent_p.E177E|CDYL_uc011dhy.1_Silent_p.E177E	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	363					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		AGTCCTCAGAGAATAACTCAC	0.532													23	70					0	0	0	0	A	4935984	A	A	4935984	2	1	184	1	0	0	0	0	0	0	0	1	3200	933	33	2		2	CDYL	6	4935984	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08		4935984	166179083	35	34310											
GCM2	9247	broad.mit.edu	37	chr6	10874807	10874807	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatagctgctgtatgaattGacattacattgtagtgtgtt	10	17	9	5	0	1	2	1	2	0	0	1	2	1	2	0	0	3	5	0	0	5	7			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:10874807G>A	uc003mzn.3	-	5	1014	c.942C>T	c.(940-942)GTC>GTT	p.V314V	SYCP2L_uc011dim.1_Intron	NM_004752	NP_004743	O75603	GCM2_HUMAN	glial cells missing homolog 2	314					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				TGTATGAATTGACATTACATT	0.428													52	131					0	0	0	0	A	10874807	A	A	10874807	2	1	184	1	0	0	0	0	0	0	0	1	6333	1277	45	2		2	GCM2	6	10874807	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08	5938823	10874807	160240260	36	34311											
HLA-A	3105	broad.mit.edu	37	chr6	29910349	29910349	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatggccgtcatggcgcccCgaaccctcctcctgctactc	5	8	10	18	3	1	0	1	0	0	0	4	2	3	1	6	3	3	1	6	3	2	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:29910349C>T	uc003nol.2	+	1	19	c.19C>T	c.(19-21)CGA>TGA	p.R7*	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Nonsense_Mutation_p.R7*|HLA-A_uc003noo.2_Nonsense_Mutation_p.R7*|HLA-A_uc010jrr.2_Nonsense_Mutation_p.R7*|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_5'Flank|HLA-A_uc011dmc.1_5'Flank|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	7					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CATGGCGCCCCGAACCCTCCT	0.677									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			11	33					0	0	0	0	T	29910349	T	T	29910349	4	4	184	1	0	0	0	0	0	1	0	0	7234	644	23	1	21	1	HLA-A	6	29910349	Nonsense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	19035542	29910349	141204718	37	34312											
HSPA1L	3305	broad.mit.edu	37	chr6	31778484	31778484	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atctgtgtctgcttggtgggGatggtggagttgcgctttat	4	16	16	5	1	2	0	0	0	2	0	2	2	2	2	0	5	2	3	0	5	1	4			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:31778484G>A	uc003nxh.2	-	2	1449	c.1266C>T	c.(1264-1266)ATC>ATT	p.I422I	HSPA1L_uc010jte.2_Silent_p.I422I	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	422					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						GCTTGGTGGGGATGGTGGAGT	0.597													23	68					0	0	0	0	A	31778484	A	A	31778484	2	1	184	1	0	0	0	0	0	0	0	1	7449	1164	41	2		2	HSPA1L	6	31778484	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08	1868135	31778484	139336583	38	34313											
RSPH9	221421	broad.mit.edu	37	chr6	43638533	43638533	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtcttatctcagggtcctgGagcatccagatggagagggg	8	10	15	8	0	2	2	1	0	2	2	5	4	4	3	2	5	1	1	2	5	1	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:43638533G>T	uc003ovw.1	+	5	704	c.678G>T	c.(676-678)TGG>TGT	p.W226C	RSPH9_uc003ovx.1_Nonsense_Mutation_p.E244*	NM_152732	NP_689945	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog	226					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton		p.W226C(1)		upper_aerodigestive_tract(1)|skin(1)	2						CAGGGTCCTGGAGCATCCAGA	0.642									Kartagener_syndrome				6	51					7.48243e-07	8.19504e-07	1	0	T	43638533	T	T	43638533	3	4	184	1	0	0	0	0	1	0	0	0	13773	1183	41	2	696	2	RSPH9	6	43638533	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	11860049	43638533	127476534	39	34314											
COL21A1	81578	broad.mit.edu	37	chr6	56047356	56047357	+	Frame_Shift_Del	DEL	AC	-	-																															tacttccccatcttcagctaAcacagaattctgaagaagca																										TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:56047356_56047357delAC	uc003pcs.2	-	2	292_293	c.60_61delGT	c.(58-63)GTGTTAfs	p.V20fs	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Frame_Shift_Del_p.V20fs|COL21A1_uc003pcu.1_Frame_Shift_Del_p.V20fs	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	20_21					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TCTTCAGCTAACACAGAATTCT	0.347													---	---	---								-	56047357	-	-	56047356	7	5	184	1	0	1	0	1	0	0	0	0	3695	40	2	0	2928	0	COL21A1	6	56047356	Frame_Shift_Del	DEL	AC	TCGA-CV-5976-01A-11D-1683-08	12408823	56047356	115067711	40	34315											
WASF1	8936	broad.mit.edu	37	chr6	110423257	110423257	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaggtggaggtgggggaggTactggagggggaggagttga	8	6	26	1	0	0	1	0	1	0	0	0	7	0	7	0	11	1	2	0	11	1	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr6:110423257T>G	uc003ptv.1	-	10	1893	c.1056A>C	c.(1054-1056)GTA>GTC	p.V352V	WASF1_uc003ptw.1_Silent_p.V352V|WASF1_uc003ptx.1_Silent_p.V352V|WASF1_uc003pty.1_Silent_p.V352V	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	352	Poly-Pro.				actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		GTGGGGGAGGTACTGGAGGGG	0.572													8	33					0	0	0	0	G	110423257	G	G	110423257	2	3	184	1	0	0	0	0	0	0	0	1	17320	1625	57	5		5	WASF1	6	110423257	Silent	SNP	T	TCGA-CV-5976-01A-11D-1683-08	54375901	110423257	60691810	41	34316											
ETV1	2115	broad.mit.edu	37	chr7	13935510	13935510	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttaatacacgtagccttcgTtgtaggggtgggggttgcag	7	12	16	6	2	0	0	0	0	0	0	1	0	0	0	1	4	3	6	1	4	4	7			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:13935510T>C	uc011jxq.1	-	14	2154	c.1415A>G	c.(1414-1416)AAC>AGC	p.N472S	ETV1_uc011jxn.1_Missense_Mutation_p.N432S|ETV1_uc011jxo.1_Missense_Mutation_p.N369S|ETV1_uc011jxp.1_Missense_Mutation_p.N414S|ETV1_uc003ssw.3_Missense_Mutation_p.N449S|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.N454S|ETV1_uc011jxs.1_Missense_Mutation_p.N454S	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	472					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						GTAGCCTTCGTTGTAGGGGTG	0.483			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								6	20					0	0	0	0	C	13935510	C	C	13935510	3	2	184	1	0	0	0	0	1	0	0	0	5301	1725	60	5	22	5	ETV1	7	13935510	Missense_Mutation	SNP	T	TCGA-CV-5976-01A-11D-1683-08		13935510	145203153	42	34317											
TMEM195	392636	broad.mit.edu	37	chr7	15599868	15599868	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgacaacaagttcaagcAgcatcaaagaaatgaaaaat	21	6	7	7	0	2	3	2	2	0	1	2	3	2	3	0	0	4	4	0	0	7	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:15599868A>T	uc003stb.1	-	2	325	c.155T>A	c.(154-156)CTG>CAG	p.L52Q		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	52	Helical; (Potential).				ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						AAGTTCAAGCAGCATCAAAGA	0.378													18	47					0	0	0	0	T	15599868	T	T	15599868	3	4	184	1	0	0	0	0	1	0	0	0	16183	188	7	5	1230	5	TMEM195	7	15599868	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	1664358	15599868	143538795	43	34318											
ELMO1	9844	broad.mit.edu	37	chr7	37264524	37264524	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggccgatggtgatctcctGcgccactttctggtagaggt	5	12	13	11	2	2	2	0	1	2	1	3	3	2	2	3	4	1	1	3	4	1	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:37264524G>A	uc003tfk.1	-	9	968	c.661C>T	c.(661-663)CAG>TAG	p.Q221*	ELMO1_uc011kbc.1_Nonsense_Mutation_p.Q125*|ELMO1_uc010kxg.1_Nonsense_Mutation_p.Q221*	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	221					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding	p.Q221*(1)		ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GTGATCTCCTGCGCCACTTTC	0.532													13	29					0	0	0	0	A	37264524	A	A	37264524	4	1	184	1	0	0	0	0	0	1	0	0	5089	1328	46	4	1578	4	ELMO1	7	37264524	Nonsense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	21664656	37264524	121874139	44	34319											
EPDR1	54749	broad.mit.edu	37	chr7	37988572	37988572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctcaaaactccacctttGaagaccagtactccatcggg	11	10	6	14	1	1	2	1	1	0	1	5	2	4	2	5	1	2	1	5	1	4	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:37988572G>A	uc003tfp.2	+	2	779	c.760G>A	c.(760-762)GAA>AAA	p.E254K	EPDR1_uc003tfq.2_Intron|EPDR1_uc010kxh.2_Missense_Mutation_p.E73K	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	134					cell-matrix adhesion	extracellular region	calcium ion binding	p.E254K(1)		upper_aerodigestive_tract(1)	1						CTCCACCTTTGAAGACCAGTA	0.512													15	26					0	0	0	0	A	37988572	A	A	37988572	3	1	184	1	0	0	0	0	1	0	0	0	5187	1291	45	2	766	2	EPDR1	7	37988572	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	724048	37988572	121150091	45	34320											
PIK3CG	5294	broad.mit.edu	37	chr7	106508605	106508605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caagctctacgccatgcaccCgtgggtgacgtccaagcccc	8	6	10	17	3	1	1	0	1	1	0	2	1	2	1	5	1	4	2	5	1	3	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:106508605C>T	uc003vdv.3	+	2	684	c.599C>T	c.(598-600)CCG>CTG	p.P200L	PIK3CG_uc003vdu.2_Missense_Mutation_p.P200L|PIK3CG_uc003vdw.2_Missense_Mutation_p.P200L	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	200					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GCCATGCACCCGTGGGTGACG	0.622													15	50					0	0	0	0	T	106508605	T	T	106508605	3	4	184	1	0	0	0	0	1	0	0	0	11971	652	23	1	601	1	PIK3CG	7	106508605	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	68520033	106508605	52630058	46	34321											
GCC1	79571	broad.mit.edu	37	chr7	127223255	127223255	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtccttctgcttggctttctCgtaggtgcctagcagctcag	4	14	11	12	1	3	0	1	0	2	0	5	0	4	0	2	2	4	5	2	2	2	5			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr7:127223255C>T	uc003vma.2	-	2	1559	c.1141G>A	c.(1141-1143)GAG>AAG	p.E381K		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	381	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						TTGGCTTTCTCGTAGGTGCCT	0.547													32	92					0	0	0	0	T	127223255	T	T	127223255	3	4	184	1	0	0	0	0	1	0	0	0	6320	893	31	1	1190	1	GCC1	7	127223255	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	20714650	127223255	31915408	47	34322											
RB1CC1	9821	broad.mit.edu	37	chr8	53573780	53573780	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taacagctctattacgaggcGgagcaaagcttgtaacttct	12	11	9	9	2	2	0	0	0	2	0	2	2	2	1	0	2	6	4	0	2	5	6	rs151174558		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr8:53573780G>A	uc003xre.3	-	10	1978	c.1420C>T	c.(1420-1422)CGC>TGC	p.R474C	RB1CC1_uc003xrf.3_Missense_Mutation_p.R474C	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	474					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding	p.R474C(1)		ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				ATTACGAGGCGGAGCAAAGCT	0.378													16	66					0	0	0	0	A	53573780	A	A	53573780	3	1	184	1	0	0	0	0	1	0	0	0	13164	1116	39	1	3424	1	RB1CC1	8	53573780	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08		53573780	92790242	48	34323											
EPPK1	83481	broad.mit.edu	37	chr8	144944533	144944533	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggccgcctgggcctccagCagggccagggccaccctggg	4	4	17	16	1	0	0	0	0	0	0	1	0	1	0	7	5	1	1	7	5	0	0			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr8:144944533C>T	uc003zaa.1	-	1	2902	c.2889G>A	c.(2887-2889)CTG>CTA	p.L963L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	963	Plectin 18.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGCCTCCAGCAGGGCCAGGG	0.716													3	12					0	0	0	0	T	144944533	T	T	144944533	2	4	184	1	0	0	0	0	0	0	0	1	5214	697	25	4		4	EPPK1	8	144944533	Silent	SNP	C	TCGA-CV-5976-01A-11D-1683-08	91370753	144944533	1419489	49	34324											
PLEC	5339	broad.mit.edu	37	chr8	144993862	144993862	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctctcagcaggccccggCgcatggcctcgtagatggac	6	7	14	14	3	1	1	1	0	1	1	3	2	1	2	3	5	1	4	3	5	1	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr8:144993862C>T	uc003zaf.1	-	32	10708	c.10538G>A	c.(10537-10539)CGC>CAC	p.R3513H	PLEC_uc003zab.1_Missense_Mutation_p.R3376H|PLEC_uc003zac.1_Missense_Mutation_p.R3380H|PLEC_uc003zad.2_Missense_Mutation_p.R3376H|PLEC_uc003zae.1_Missense_Mutation_p.R3344H|PLEC_uc003zag.1_Missense_Mutation_p.R3354H|PLEC_uc003zah.2_Missense_Mutation_p.R3362H|PLEC_uc003zaj.2_Missense_Mutation_p.R3403H	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3513	Plectin 12.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CAGGCCCCGGCGCATGGCCTC	0.687													12	27					0	0	0	0	T	144993862	T	T	144993862	3	4	184	1	0	0	0	0	1	0	0	0	12107	768	27	1	3520	1	PLEC	8	144993862	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	49329	144993862	1370160	50	34325											
CDKN2A	1029	broad.mit.edu	37	chr9	21971108	21971108	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagccctcccgggcagcgtCgtgcacgggtcgggtgagag	6	5	18	12	5	0	1	0	1	0	1	3	3	1	1	2	3	3	2	2	3	1	0	rs11552822		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr9:21971108C>T	uc003zpk.2	-	2	462	c.250G>A	c.(250-252)GAC>AAC	p.D84N	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.R139Q	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	84	ANK 3.		D -> E (in a bladder tumor).|D -> N (in an esophagus, a head and neck and a lung tumor).|D -> H (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.D84Y(9)|p.D84V(4)|p.D84N(3)|p.D84G(2)|p.D84fs*63(2)|p.D84H(2)|p.H83fs*2(2)|p.D84_F90del(1)|p.D84D(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.D84fs*0(1)|p.E61_L94del(1)|p.D84fs*36(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGGGCAGCGTCGTGCACGGGT	0.741	D84Y(LK2_LUNG)|D84Y(DU145_PROSTATE)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			4	5					0	0	0	0	T	21971108	T	T	21971108	3	4	184	1	0	0	0	0	1	0	0	0	3176	884	31	1	228	1	CDKN2A	9	21971108	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08		21971108	119242323	51	34326											
ZNF510	22869	broad.mit.edu	37	chr9	99522150	99522150	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattatattcctccacagttGacttctcaaaggatttccca	11	15	4	11	0	1	1	1	1	1	0	5	2	4	2	3	1	0	1	3	1	4	7			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr9:99522150G>C	uc004awn.1	-	6	1151	c.962C>G	c.(961-963)TCA>TGA	p.S321*	ZNF510_uc004awo.1_Nonsense_Mutation_p.S321*	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				CTCCACAGTTGACTTCTCAAA	0.358													29	67					0	0	0	0	C	99522150	C	C	99522150	4	2	184	1	0	0	0	0	0	1	0	0	18021	1294	45	2	1093	2	ZNF510	9	99522150	Nonsense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	77551042	99522150	41691281	52	34327											
C9orf167	54863	broad.mit.edu	37	chr9	140173372	140173372	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggaccagccaaagttcttCaccttcgacagccccgcgga	9	7	9	16	3	2	0	1	0	1	0	3	3	2	2	5	2	2	1	5	2	1	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr9:140173372C>T	uc004cmn.2	+	2	348	c.231C>T	c.(229-231)TTC>TTT	p.F77F	C9orf167_uc011mew.1_5'Flank	NM_017723	NP_060193	Q9NXH8	CI167_HUMAN	hypothetical protein LOC54863	77					chaperone mediated protein folding requiring cofactor	integral to membrane	ATP binding|nucleoside-triphosphatase activity			pancreas(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.07e-05)|Epithelial(140;0.000728)		CAAAGTTCTTCACCTTCGACA	0.736													4	4					0	0	0	0	T	140173372	T	T	140173372	2	4	184	1	0	0	0	0	0	0	0	1	2480	825	29	2		2	C9orf167	9	140173372	Silent	SNP	C	TCGA-CV-5976-01A-11D-1683-08	40651222	140173372	1040059	53	34328											
PRDM11	56981	broad.mit.edu	37	chr11	45246383	45246383	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actggagctcccagagttctCggaccctgcaggtaagttgg	8	9	13	11	1	1	1	0	0	1	1	3	3	2	3	2	4	2	5	2	4	1	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:45246383C>T	uc001myo.2	+	8	1709	c.1460C>T	c.(1459-1461)TCG>TTG	p.S487L		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	487								p.S487L(1)		upper_aerodigestive_tract(1)	1						CCAGAGTTCTCGGACCCTGCA	0.542													30	68					0	0	0	0	T	45246383	T	T	45246383	3	4	184	1	0	0	0	0	1	0	0	0	12514	893	31	1	1486	1	PRDM11	11	45246383	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08		45246383	89760133	54	34329											
OR4A15	81328	broad.mit.edu	37	chr11	55135388	55135388	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgacaaataatctcaaatTtatcactgacccttttgttt	12	17	3	9	0	3	2	2	2	2	0	4	2	3	2	1	0	0	1	1	0	4	6			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:55135388T>A	uc010rif.1	+	1	29	c.29T>A	c.(28-30)TTT>TAT	p.F10Y		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AATCTCAAATTTATCACTGAC	0.408													7	43					0	0	0	0	A	55135388	A	A	55135388	3	1	184	1	0	0	0	0	1	0	0	0	11094	1841	64	5	31	5	OR4A15	11	55135388	Missense_Mutation	SNP	T	TCGA-CV-5976-01A-11D-1683-08	9889005	55135388	79871128	55	34330											
GLYAT	10249	broad.mit.edu	37	chr11	58478154	58478154	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtttcagctgccatatagaGaatgcgttgtgtttgtttga	8	17	11	5	1	1	2	1	1	0	1	1	3	1	2	1	0	3	5	1	0	3	6			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:58478154G>A	uc001nnb.2	-	5	552	c.397C>T	c.(397-399)CTC>TTC	p.L133F	GLYAT_uc001nnc.2_Missense_Mutation_p.L133F	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	133					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	GCCATATAGAGAATGCGTTGT	0.428													32	87					0	0	0	0	A	58478154	A	A	58478154	3	1	184	1	0	0	0	0	1	0	0	0	6516	942	33	2	505	2	GLYAT	11	58478154	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	3342766	58478154	76528362	56	34331											
ATG2A	23130	broad.mit.edu	37	chr11	64665596	64665596	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgggaccacggggttgatgCcggccaccagactagtgaag	9	6	15	11	2	0	3	0	2	0	1	0	4	0	4	4	4	1	1	4	4	2	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:64665596C>T	uc001obx.2	-	34	4935	c.4820G>A	c.(4819-4821)GGC>GAC	p.G1607D	ATG2A_uc001obw.2_Missense_Mutation_p.G372D	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1607							protein binding			ovary(1)|central_nervous_system(1)	2						GGGGTTGATGCCGGCCACCAG	0.627											OREG0004029	type=REGULATORY REGION|Gene=BC033850|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	4	143					0	0	0	0	T	64665596	T	T	64665596	3	4	184	1	0	0	0	0	1	0	0	0	1095	739	26	4	1028	4	ATG2A	11	64665596	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	6187442	64665596	70340920	57	34332											
TIGD3	220359	broad.mit.edu	37	chr11	65123651	65123651	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgcccagcatcggctggctGgtccgctggaaacgccgaaa	8	6	14	13	4	0	0	0	0	0	0	2	2	1	1	3	4	3	4	3	4	2	0			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:65123651G>A	uc001odo.3	+	2	535	c.372G>A	c.(370-372)CTG>CTA	p.L124L		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	124	H-T-H motif (By similarity).|HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						TCGGCTGGCTGGTCCGCTGGA	0.662													11	42					0	0	0	0	A	65123651	A	A	65123651	2	1	184	1	0	0	0	0	0	0	0	1	15963	1335	47	4		4	TIGD3	11	65123651	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08	458055	65123651	69882865	58	34333											
PCNXL3	399909	broad.mit.edu	37	chr11	65393198	65393198	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgccatcagcgccagcaccGtctttattgccctgaaggtt	7	11	9	14	3	2	1	1	1	1	0	3	1	2	1	4	1	3	2	4	1	2	4			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:65393198G>A	uc001oey.2	+	19	3211	c.3211G>A	c.(3211-3213)GTC>ATC	p.V1071I	PCNXL3_uc009yqn.2_Missense_Mutation_p.V31I|PCNXL3_uc001oez.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1071	Helical; (Potential).					integral to membrane					0						CGCCAGCACCGTCTTTATTGC	0.627											OREG0021084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	14					0	0	0	0	A	65393198	A	A	65393198	3	1	184	1	0	0	0	0	1	0	0	0	11647	1145	40	1	3285	1	PCNXL3	11	65393198	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	269547	65393198	69613318	59	34334											
SART1	9092	broad.mit.edu	37	chr11	65735028	65735028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgccgtcggacgacacccGagtggagaacatggacatca	11	5	12	13	4	1	1	1	0	0	1	2	6	1	3	3	3	2	0	3	3	1	0			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:65735028G>A	uc001ogl.2	+	11	1492	c.1400G>A	c.(1399-1401)CGA>CAA	p.R467Q		NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	467					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1						GACGACACCCGAGTGGAGAAC	0.682													10	20					0	0	0	0	A	65735028	A	A	65735028	3	1	184	1	0	0	0	0	1	0	0	0	13911	1058	37	1	1442	1	SART1	11	65735028	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	341830	65735028	69271488	60	34335											
MAP6	4135	broad.mit.edu	37	chr11	75298616	75298616	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttcatccttcggatgctctgGgaccatgggatcttgatcct	6	14	10	11	1	3	1	1	1	2	0	6	4	5	4	3	3	1	1	3	3	0	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:75298616G>A	uc001owu.2	-	4	1995	c.1930C>T	c.(1930-1932)CCA>TCA	p.P644S		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	644	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					GGATGCTCTGGGACCATGGGA	0.517													44	138					0	0	0	0	A	75298616	A	A	75298616	3	1	184	1	0	0	0	0	1	0	0	0	9317	1232	43	4	515	4	MAP6	11	75298616	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	9563588	75298616	59707900	61	34336											
UBE4A	9354	broad.mit.edu	37	chr11	118243810	118243810	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctgttagattttgaagAtgtaactgagtttctggaag	10	17	10	4	0	3	4	0	2	3	2	3	5	3	5	0	1	1	3	0	1	4	6	rs111254610		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr11:118243810A>C	uc001psw.2	+	7	860	c.731A>C	c.(730-732)GAT>GCT	p.D244A	UBE4A_uc001psv.2_Missense_Mutation_p.D251A	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	244					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding	p.D251A(1)		ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GATTTTGAAGATGTAACTGAG	0.328													11	24					0	0	0	0	C	118243810	C	C	118243810	3	2	184	1	0	0	0	0	1	0	0	0	16950	333	12	5	774	5	UBE4A	11	118243810	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	42945194	118243810	16762706	62	34337											
NELL2	4753	broad.mit.edu	37	chr12	45170851	45170851	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgatgttttggctaaaatatCctgtagctccatgattttct	9	18	7	7	0	1	2	0	2	1	0	3	2	3	2	2	1	1	4	2	1	4	7			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:45170851C>G	uc001rog.2	-	7	1331	c.736G>C	c.(736-738)GAT>CAT	p.D246H	NELL2_uc001rof.3_Missense_Mutation_p.D245H|NELL2_uc001roh.2_Missense_Mutation_p.D246H|NELL2_uc009zkd.2_Missense_Mutation_p.D245H|NELL2_uc010skz.1_Missense_Mutation_p.D296H|NELL2_uc010sla.1_Missense_Mutation_p.D269H|NELL2_uc001roi.1_Missense_Mutation_p.D246H|NELL2_uc010slb.1_Missense_Mutation_p.D245H|NELL2_uc001roj.2_Missense_Mutation_p.D246H	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	246	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity	p.D246H(1)		skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GCTAAAATATCCTGTAGCTCC	0.378													12	49					0	0	0	0	G	45170851	G	G	45170851	3	3	184	1	0	0	0	0	1	0	0	0	10388	855	30	2	1770	2	NELL2	12	45170851	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08		45170851	88681044	63	34338											
ARID2	196528	broad.mit.edu	37	chr12	46244616	46244616	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccaaaacctctcccttctCagcaagtttcatctacagtg	11	11	4	15	0	4	0	2	0	3	0	6	0	4	0	3	0	3	2	3	0	4	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:46244616C>T	uc001ros.1	+	15	2710	c.2710C>T	c.(2710-2712)CAG>TAG	p.Q904*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q904*|ARID2_uc009zkg.1_Nonsense_Mutation_p.Q360*|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q531*|ARID2_uc001rou.1_Nonsense_Mutation_p.Q238*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	904	Gln-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.Q904*(1)		ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCTCCCTTCTCAGCAAGTTTC	0.483													16	63					0	0	0	0	T	46244616	T	T	46244616	4	4	184	1	0	0	0	0	0	1	0	0	915	827	29	2	2768	2	ARID2	12	46244616	Nonsense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	1073765	46244616	87607279	64	34339											
PAN2	9924	broad.mit.edu	37	chr12	56720656	56720656	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcttgctggctgacacatcaAatgtcattagcagaggcccc	10	9	10	12	0	2	2	2	1	0	1	2	2	2	2	2	2	2	4	2	2	2	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:56720656A>T	uc001skx.2	-	7	1380	c.1007T>A	c.(1006-1008)TTT>TAT	p.F336Y	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.F336Y|PAN2_uc001sky.2_Missense_Mutation_p.F336Y	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	336					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TGACACATCAAATGTCATTAG	0.557													32	71					0	0	0	0	T	56720656	T	T	56720656	3	4	184	1	0	0	0	0	1	0	0	0	11468	14	1	5	2681	5	PAN2	12	56720656	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	10476040	56720656	77131239	65	34340											
TMEM132D	121256	broad.mit.edu	37	chr12	129559527	129559527	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagatgtggccatcaaggaGaagtctttcccatcgtaaat	14	10	9	8	1	2	2	1	0	1	2	4	3	3	2	2	2	0	1	2	2	5	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:129559527G>T	uc009zyl.1	-	9	2521	c.2193C>A	c.(2191-2193)TTC>TTA	p.F731L	TMEM132D_uc001uia.2_Missense_Mutation_p.F269L	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	731	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CCATCAAGGAGAAGTCTTTCC	0.473													13	35					1.61879e-10	1.82511e-10	1	0	T	129559527	T	T	129559527	3	4	184	1	0	0	0	0	1	0	0	0	16113	933	33	2	1110	2	TMEM132D	12	129559527	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	72838871	129559527	4292368	66	34341											
TMEM132D	121256	broad.mit.edu	37	chr12	130184386	130184386	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgatcttcagtggaatttcTggagatggaaacaggaaaag	14	9	13	5	1	3	1	1	0	2	1	3	6	3	4	0	4	1	0	0	4	4	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr12:130184386T>C	uc009zyl.1	-	2	1265	c.937A>G	c.(937-939)AGA>GGA	p.R313G		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	313	Extracellular (Potential).					integral to membrane		p.R313G(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GTGGAATTTCTGGAGATGGAA	0.502													10	22					0	0	0	0	C	130184386	C	C	130184386	3	2	184	1	0	0	0	0	1	0	0	0	16113	1588	55	5	2394	5	TMEM132D	12	130184386	Missense_Mutation	SNP	T	TCGA-CV-5976-01A-11D-1683-08	624859	130184386	3667509	67	34342											
B3GALTL	145173	broad.mit.edu	37	chr13	31891811	31891811	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtggctacagctacatcacGggaggaggagggtaactatg	11	7	16	7	1	1	0	1	0	0	0	1	3	1	3	0	6	4	3	0	6	4	4			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr13:31891811G>A	uc010aaz.2	+	13	1283	c.1173G>A	c.(1171-1173)ACG>ACA	p.T391T	B3GALTL_uc001utn.3_RNA	NM_194318	NP_919299	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	391	Lumenal (Potential).				fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		GCTACATCACGGGAGGAGGAG	0.527													15	50					0	0	0	0	A	31891811	A	A	31891811	2	1	184	1	0	0	0	0	0	0	0	1	1254	1103	39	1		1	B3GALTL	13	31891811	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08		31891811	83278067	68	34343											
RPGRIP1	57096	broad.mit.edu	37	chr14	21771560	21771560	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaacccattggtctatgcAtgcctaacagtgcccacatc	11	10	6	14	0	1	0	0	0	1	0	2	0	1	0	3	1	5	1	3	1	4	4			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:21771560A>G	uc001wag.2	+	5	658	c.658A>G	c.(658-660)ATG>GTG	p.M220V		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	220					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TGGTCTATGCATGCCTAACAG	0.403													9	24					0	0	0	0	G	21771560	G	G	21771560	3	3	184	1	0	0	0	0	1	0	0	0	13614	217	8	5	676	5	RPGRIP1	14	21771560	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08		21771560	85577980	69	34344											
HECTD1	25831	broad.mit.edu	37	chr14	31598317	31598317	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaattggttcatggacatcAgctcctgaaactatactgtg	12	12	8	9	0	2	1	2	1	0	0	3	2	3	2	1	2	3	2	1	2	4	4			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:31598317A>C	uc001wrc.1	-	25	4749	c.4260T>G	c.(4258-4260)GCT>GCG	p.A1420A	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Silent_p.A888A	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1420	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CATGGACATCAGCTCCTGAAA	0.478													3	126					0	0	0	0	C	31598317	C	C	31598317	2	2	184	1	0	0	0	0	0	0	0	1	7078	175	7	5		5	HECTD1	14	31598317	Silent	SNP	A	TCGA-CV-5976-01A-11D-1683-08	9826757	31598317	75751223	70	34345											
FSCB	84075	broad.mit.edu	37	chr14	44974982	44974982	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggggcctcttcaagggcGccctcagctggtaaaggctg	6	8	15	12	1	3	0	2	0	1	0	3	0	3	0	2	5	1	4	2	5	3	2	rs140508672	by1000genomes	TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:44974982G>A	uc001wvn.2	-	1	1518	c.1209C>T	c.(1207-1209)GGC>GGT	p.G403G		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	403	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CTTCAAGGGCGCCCTCAGCTG	0.517													20	69					0	0	0	0	A	44974982	A	A	44974982	2	1	184	1	0	0	0	0	0	0	0	1	6100	1074	38	1		1	FSCB	14	44974982	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08	13376665	44974982	62374558	71	34346											
ATP5S	27109	broad.mit.edu	37	chr14	50792426	50792426	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgccttctctggaactaaaAttacaattgaagtaaaataa	17	12	5	7	0	1	1	0	1	1	0	2	2	1	2	1	1	3	1	1	1	9	6			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:50792426A>G	uc001wxw.1	+	5	1325	c.633A>G	c.(631-633)AAA>AAG	p.K211K	ATP5S_uc001wxx.1_3'UTR|ATP5S_uc010ant.1_Intron	NM_001003803	NP_001003803	Q99766	ATP5S_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	211					ATP biosynthetic process	mitochondrial inner membrane|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			ovary(1)|skin(1)	2	all_epithelial(31;0.000636)|Breast(41;0.0102)			OV - Ovarian serous cystadenocarcinoma(311;0.0685)		TGGAACTAAAATTACAATTGA	0.308													28	55					0	0	0	0	G	50792426	G	G	50792426	2	3	184	1	0	0	0	0	0	0	0	1	1165	98	4	5		5	ATP5S	14	50792426	Silent	SNP	A	TCGA-CV-5976-01A-11D-1683-08	5817444	50792426	56557114	72	34347											
SMOC1	64093	broad.mit.edu	37	chr14	70490018	70490018	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcaacgacattaacaagcGggagatgaagcccttcaagc	15	5	10	11	2	1	2	1	1	0	1	1	4	1	2	1	1	6	1	1	1	5	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:70490018G>A	uc001xls.1	+	11	1398	c.1145G>A	c.(1144-1146)CGG>CAG	p.R382Q	SMOC1_uc001xlt.1_Missense_Mutation_p.R382Q	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	382	EF-hand 1.|1 (Potential).				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding	p.R382Q(1)		upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ATTAACAAGCGGGAGATGAAG	0.542													20	61					0	0	0	0	A	70490018	A	A	70490018	3	1	184	1	0	0	0	0	1	0	0	0	14865	1116	39	1	1187	1	SMOC1	14	70490018	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	19697592	70490018	36859522	73	34348											
FAM161B	145483	broad.mit.edu	37	chr14	74413239	74413239	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtcaagtttgctggccctggGcaaaaccagcccatccccgg	8	7	11	15	1	1	0	1	0	0	0	2	0	2	0	5	3	3	3	5	3	3	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr14:74413239G>A	uc001xpd.1	-	2	230	c.124C>T	c.(124-126)CCC>TCC	p.P42S		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						CTGGCCCTGGGCAAAACCAGC	0.507													4	139					0	0	0	0	A	74413239	A	A	74413239	3	1	184	1	0	0	0	0	1	0	0	0	5501	1203	42	4	1851	4	FAM161B	14	74413239	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	3923221	74413239	32936301	74	34349											
MGA	23269	broad.mit.edu	37	chr15	42003295	42003297	+	In_Frame_Del	DEL	CAT	-	-																															gttaccaagaattcttcaggCatcatctcagaaaatcaggc																										TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr15:42003295_42003297delCAT	uc001zog.1	+	8	2923_2925	c.2832_2834delCAT	c.(2830-2835)GGCATC>GGC	p.I946del	MGA_uc010ucy.1_In_Frame_Del_p.I946del|MGA_uc010ucz.1_In_Frame_Del_p.I946del	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	946						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		ATTCTTCAGGCATCATCTCAGAA	0.384													---	---	---								-	42003297	-	-	42003295	7	5	184	1	0	1	0	1	0	0	0	0	9593	697	25	0	2858	0	MGA	15	42003295	In_Frame_Del	DEL	CAT	TCGA-CV-5976-01A-11D-1683-08		42003295	60528097	75	34350											
MAPKBP1	23005	broad.mit.edu	37	chr15	42110413	42110413	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagacagacccctcagggAtctacattgccaccagctgt	10	8	9	14	0	2	2	1	0	1	2	2	3	2	3	4	1	4	2	4	1	1	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr15:42110413A>T	uc001zok.3	+	19	2306	c.2020A>T	c.(2020-2022)ATC>TTC	p.I674F	MAPKBP1_uc001zoj.3_Missense_Mutation_p.I668F|MAPKBP1_uc010bcj.2_Missense_Mutation_p.I175F|MAPKBP1_uc010bci.2_Missense_Mutation_p.I668F|MAPKBP1_uc010udb.1_Missense_Mutation_p.I507F|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Missense_Mutation_p.I175F	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	674	WD 11.							p.I668F(1)		central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CCCCTCAGGGATCTACATTGC	0.572													11	49					0	0	0	0	T	42110413	T	T	42110413	3	4	184	1	0	0	0	0	1	0	0	0	9345	333	12	5	2090	5	MAPKBP1	15	42110413	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	107118	42110413	60420979	76	34351											
IL16	3603	broad.mit.edu	37	chr15	81592385	81592385	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgagcaagtactgtcctcGgggtcccctgcagcctccga	6	8	11	16	2	0	1	0	1	0	0	4	2	3	1	6	2	4	3	6	2	2	1	rs142057384		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr15:81592385G>A	uc002bgh.3	+	14	3094	c.2718G>A	c.(2716-2718)TCG>TCA	p.S906S	IL16_uc010blq.1_Silent_p.S860S|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Silent_p.S948S|IL16_uc002bgg.2_Silent_p.S906S|IL16_uc002bgi.1_Silent_p.S296S|IL16_uc002bgj.2_Silent_p.S400S|IL16_uc002bgk.2_Silent_p.S205S|IL16_uc002bgl.1_Silent_p.S205S|IL16_uc010unq.1_Silent_p.S205S	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	906					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						TACTGTCCTCGGGGTCCCCTG	0.647													3	78					0	0	0	0	A	81592385	A	A	81592385	2	1	184	1	0	0	0	0	0	0	0	1	7672	1103	39	1		1	IL16	15	81592385	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08	39481972	81592385	20939007	77	34352											
FLYWCH1	84256	broad.mit.edu	37	chr16	2983757	2983757	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acgcccctggggggcagcttCctggtgtacgagtccttcct	4	10	13	14	2	0	0	0	0	0	0	3	1	3	0	5	4	2	3	5	4	1	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr16:2983757C>T	uc002csd.2	+	6	1653	c.1290C>T	c.(1288-1290)TTC>TTT	p.F430F	FLYWCH1_uc002csb.2_Silent_p.F429F|FLYWCH1_uc002csc.2_Silent_p.F429F|FLYWCH1_uc010bsv.2_Silent_p.F105F	NM_032296	NP_115672	Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1 isoform a	430	FLYWCH-type 3.					nucleus	DNA binding|metal ion binding				0						GGGGCAGCTTCCTGGTGTACG	0.682													7	9					0	0	0	0	T	2983757	T	T	2983757	2	4	184	1	0	0	0	0	0	0	0	1	5979	854	30	2		2	FLYWCH1	16	2983757	Silent	SNP	C	TCGA-CV-5976-01A-11D-1683-08		2983757	87370996	78	34353											
TP53	7157	broad.mit.edu	37	chr17	7578190	7578190	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accagacctcaggcggctcaTagggcaccaccacactatgt	11	6	9	15	1	2	1	2	0	0	1	2	1	2	1	4	3	0	2	4	3	2	2	rs121912666		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr17:7578190T>C	uc002gim.2	-	6	853	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	TP53_uc002gig.1_Missense_Mutation_p.Y220C|TP53_uc002gih.2_Missense_Mutation_p.Y220C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y88C|TP53_uc010cng.1_Missense_Mutation_p.Y88C|TP53_uc002gii.1_Missense_Mutation_p.Y88C|TP53_uc010cnh.1_Missense_Mutation_p.Y220C|TP53_uc010cni.1_Missense_Mutation_p.Y220C|TP53_uc002gij.2_Missense_Mutation_p.Y220C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y127C|TP53_uc002gio.2_Missense_Mutation_p.Y88C|TP53_uc010vug.1_Missense_Mutation_p.Y181C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	220	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(205)|p.Y220N(12)|p.Y220H(9)|p.Y220S(9)|p.0?(7)|p.Y220fs*27(4)|p.Y220*(3)|p.Y220D(2)|p.Y127C(2)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.?(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*1(1)|p.Y220fs*2(1)|p.V218fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	15					0	0	0	0	C	7578190	C	C	7578190	3	2	184	1	0	0	0	0	1	0	0	0	16448	1406	49	5	635	5	TP53	17	7578190	Missense_Mutation	SNP	T	TCGA-CV-5976-01A-11D-1683-08		7578190	73617020	79	34354											
TP53	7157	broad.mit.edu	37	chr17	7579358	7579358	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaatgcaagaagcccagaCggaaaccgtagctgccctgg	13	4	12	12	2	0	3	0	0	0	3	0	4	0	4	3	2	5	3	3	2	5	1	rs11540654		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr17:7579358C>A	uc002gim.2	-	4	523	c.329G>T	c.(328-330)CGT>CTT	p.R110L	TP53_uc002gig.1_Missense_Mutation_p.R110L|TP53_uc002gih.2_Missense_Mutation_p.R110L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.R110L|TP53_uc010cni.1_Missense_Mutation_p.R110L|TP53_uc002gij.2_Missense_Mutation_p.R110L|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.R71L|TP53_uc010cnk.1_Missense_Mutation_p.R125L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	110	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		R -> G (in a sporadic cancer; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> H (in sporadic cancers; somatic mutation).|R -> L (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R110L(24)|p.R110P(8)|p.0?(7)|p.R110fs*13(5)|p.R110C(4)|p.G59fs*23(3)|p.F109_R110delFR(2)|p.R110H(2)|p.V73fs*9(1)|p.F109_R110insXX(1)|p.G105_T125del21(1)|p.R110fs*18(1)|p.Y107fs*44(1)|p.R110fs*39(1)|p.Y103_G112>C(1)|p.R110S(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y107fs*38(1)|p.Y103_L111>L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAGCCCAGACGGAAACCGTA	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	45					0.000422831	0.000446107	1	0	A	7579358	A	A	7579358	3	1	184	1	0	0	0	0	1	0	0	0	16448	536	19	3	973	3	TP53	17	7579358	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	1168	7579358	73615852	80	34355											
GPR179	440435	broad.mit.edu	37	chr17	36485397	36485397	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccttcctggcctccacaCtgtcccccgcctcagatttg	5	10	6	20	1	1	1	1	0	0	1	4	1	4	1	8	1	0	0	8	1	0	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr17:36485397C>A	uc002hpz.2	-	11	4076	c.4055G>T	c.(4054-4056)AGT>ATT	p.S1352I		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1352	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GGCCTCCACACTGTCCCCCGC	0.627													10	44					1.58986e-06	1.72485e-06	1	0	A	36485397	A	A	36485397	3	1	184	1	0	0	0	0	1	0	0	0	6712	565	20	4	3052	4	GPR179	17	36485397	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	28906039	36485397	44709813	81	34356											
DCC	1630	broad.mit.edu	37	chr18	50942511	50942511	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagtggaacaccctgacaaaAtggctaatgaccaaggtatg	15	7	10	9	0	0	2	0	2	0	0	0	3	0	3	2	3	1	2	2	3	6	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr18:50942511A>C	uc002lfe.1	+	21	3735	c.3148A>C	c.(3148-3150)ATG>CTG	p.M1050L	DCC_uc010xdr.1_Missense_Mutation_p.M878L|DCC_uc010dpf.1_Missense_Mutation_p.M685L	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1050	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane		p.M1050L(1)		skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCCTGACAAAATGGCTAATGA	0.378													10	10					0	0	0	0	C	50942511	C	C	50942511	3	2	184	1	0	0	0	0	1	0	0	0	4299	101	4	5	3230	5	DCC	18	50942511	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08		50942511	27134737	82	34357											
DOK6	220164	broad.mit.edu	37	chr18	67406313	67406313	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgagcaacatgaaagattaAtgctagaaatggaacagaag	19	7	10	5	0	0	5	0	2	0	3	0	6	0	6	0	1	4	2	0	1	7	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr18:67406313A>T	uc002lkl.2	+	6	902	c.712A>T	c.(712-714)ATG>TTG	p.M238L		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	238				M -> V (in Ref. 5; BAB71577).			insulin receptor binding	p.M238L(1)		upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TGAAAGATTAATGCTAGAAAT	0.443													34	35					0	0	0	0	T	67406313	T	T	67406313	3	4	184	1	0	0	0	0	1	0	0	0	4723	101	4	5	734	5	DOK6	18	67406313	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	16463802	67406313	10670935	83	34358											
CTDP1	9150	broad.mit.edu	37	chr18	77489013	77489013	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcgacagcccagtatgtctGagacaatgccgctgtacact	11	8	10	12	2	1	1	0	1	1	1	1	3	1	1	2	0	4	3	2	0	3	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr18:77489013G>C	uc002lnh.1	+	11	2671	c.2524G>C	c.(2524-2526)GAG>CAG	p.E842Q	CTDP1_uc002lni.1_Intron|CTDP1_uc010drd.1_Missense_Mutation_p.E842Q	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	842					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CAGTATGTCTGAGACAATGCC	0.592													4	189					0	0	0	0	C	77489013	C	C	77489013	3	2	184	1	0	0	0	0	1	0	0	0	4019	1291	45	2	2566	2	CTDP1	18	77489013	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	10082700	77489013	588235	84	34359											
LONP1	9361	broad.mit.edu	37	chr19	5699115	5699115	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcggttcagggcgcgggcGatggagcgagcaatgctggt	6	8	18	9	5	2	0	1	0	1	0	3	3	2	1	0	5	3	3	0	5	1	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr19:5699115G>A	uc002mcx.2	-	10	1641	c.1608C>T	c.(1606-1608)ATC>ATT	p.I536I	LONP1_uc002mcy.2_Silent_p.I472I|LONP1_uc010duh.2_Silent_p.I277I|LONP1_uc010dui.2_Silent_p.I520I|LONP1_uc002mcz.2_Silent_p.I340I	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	536					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						GGGCGCGGGCGATGGAGCGAG	0.632													17	71					0	0	0	0	A	5699115	A	A	5699115	2	1	184	1	0	0	0	0	0	0	0	1	8942	1048	37	1		1	LONP1	19	5699115	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08		5699115	53429868	85	34360											
FKBP8	23770	broad.mit.edu	37	chr19	18649084	18649084	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taggagttggcggccaggacGaagtccgcccgctggtagtg	7	7	17	10	4	0	0	0	0	0	0	1	3	1	2	3	5	0	3	3	5	3	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr19:18649084G>A	uc002njk.1	-	5	824	c.711C>T	c.(709-711)TTC>TTT	p.F237F	FKBP8_uc002nji.1_Silent_p.F75F|FKBP8_uc010xqi.1_Silent_p.F266F|FKBP8_uc002njj.1_Silent_p.F238F|FKBP8_uc002njl.1_Silent_p.F238F|FKBP8_uc002njm.1_Silent_p.F237F|FKBP8_uc010ebr.1_Silent_p.F76F|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	237	TPR 1.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						CGGCCAGGACGAAGTCCGCCC	0.667													5	68					0	0	0	0	A	18649084	A	A	18649084	2	1	184	1	0	0	0	0	0	0	0	1	5946	1049	37	1		1	FKBP8	19	18649084	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08	12949969	18649084	40479899	86	34361											
ZFP36	7538	broad.mit.edu	37	chr19	39898771	39898771	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagctgcgccaggccaatcGccaccccaaatacaagacgg	12	3	10	16	4	0	1	0	0	0	1	1	2	0	1	5	2	3	1	5	2	4	1			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr19:39898771G>A	uc002olh.1	+	2	471	c.413G>A	c.(412-414)CGC>CAC	p.R138H	ZFP36_uc010egn.1_Missense_Mutation_p.A11T	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	138					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGGCCAATCGCCACCCCAAA	0.612													37	93					0	0	0	0	A	39898771	A	A	39898771	3	1	184	1	0	0	0	0	1	0	0	0	17712	1087	38	1	419	1	ZFP36	19	39898771	Missense_Mutation	SNP	G	TCGA-CV-5976-01A-11D-1683-08	21249687	39898771	19230212	87	34362											
DHX34	9704	broad.mit.edu	37	chr19	47856424	47856424	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagatgccttcttccgtgAagaggattacatccgtcagg	10	10	12	9	2	2	3	1	1	1	2	4	5	4	5	3	3	2	0	3	3	3	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr19:47856424A>G	uc010xyn.1	+	2	478	c.137A>G	c.(136-138)GAA>GGA	p.E46G	DHX34_uc010elc.1_Missense_Mutation_p.E46G	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	46						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TTCTTCCGTGAAGAGGATTAC	0.537													17	40					0	0	0	0	G	47856424	G	G	47856424	3	3	184	1	0	0	0	0	1	0	0	0	4529	246	9	5	139	5	DHX34	19	47856424	Missense_Mutation	SNP	A	TCGA-CV-5976-01A-11D-1683-08	7957653	47856424	11272559	88	34363											
PPP1R12C	54776	broad.mit.edu	37	chr19	55605735	55605735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtggacctccgagactggCgcatgagacgggagcgagct	8	6	17	10	4	0	2	0	1	0	2	1	7	1	4	2	3	2	2	2	3	0	0			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr19:55605735C>T	uc002qix.2	-	13	1677	c.1661G>A	c.(1660-1662)CGC>CAC	p.R554H	PPP1R12C_uc010yfs.1_Missense_Mutation_p.R480H|PPP1R12C_uc002qiy.2_Missense_Mutation_p.R553H	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	554						cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CCGAGACTGGCGCATGAGACG	0.398													12	50					0	0	0	0	T	55605735	T	T	55605735	3	4	184	1	0	0	0	0	1	0	0	0	12416	768	27	1	727	1	PPP1R12C	19	55605735	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	7749311	55605735	3523248	89	34364											
KCNB1	3745	broad.mit.edu	37	chr20	47991218	47991218	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cggaagatctggaccacgcgGcggacattctggaattgcag	10	7	14	10	4	2	1	0	0	2	1	2	5	2	5	1	5	1	1	1	5	2	2			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chr20:47991218G>A	uc002xur.1	-	2	1043	c.879C>T	c.(877-879)CGC>CGT	p.R293R	KCNB1_uc002xus.1_Silent_p.R293R	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	293					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGACCACGCGGCGGACATTCT	0.537													20	34					0	0	0	0	A	47991218	A	A	47991218	2	1	184	1	0	0	0	0	0	0	0	1	8051	1190	42	4		4	KCNB1	20	47991218	Silent	SNP	G	TCGA-CV-5976-01A-11D-1683-08		47991218	15034302	90	34365											
CXorf22	170063	broad.mit.edu	37	chrX	35993984	35993984	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcagtttcaatggcaaccCgtaaacacaggaagagggat	14	7	11	9	1	2	1	2	0	0	1	2	3	2	3	1	3	2	4	1	3	5	2	rs138251686		TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chrX:35993984C>A	uc004ddj.2	+	15	2726	c.2667C>A	c.(2665-2667)CCC>CCA	p.P889P	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	889										large_intestine(1)|lung(1)|ovary(1)	3						AATGGCAACCCGTAAACACAG	0.348													22	38					7.87624e-14	9.05768e-14	1	0	A	35993984	A	A	35993984	2	1	184	1	0	0	0	0	0	0	0	1	4119	639	23	3		3	CXorf22	23	35993984	Silent	SNP	C	TCGA-CV-5976-01A-11D-1683-08		35993984	119276576	91	34366											
MED14	9282	broad.mit.edu	37	chrX	40511065	40511065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacaatagtgtctatggaCgcccaccagggggcagtgta	13	7	12	9	1	1	0	0	0	1	0	1	1	1	1	2	3	1	2	2	3	6	3			TCGA-CV-5976-01A-11D-1683-08	TCGA-CV-5976-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	7b643ce3-43bc-4a14-942a-0d6fcffa0312	2a7557e4-67ae-450b-be12-566874b58886	g.chrX:40511065C>T	uc004dex.3	-	31	4498	c.4358G>A	c.(4357-4359)CGT>CAT	p.R1453H		NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	1453					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						TGTCTATGGACGCCCACCAGG	0.388													3	3					0	0	0	0	T	40511065	T	T	40511065	3	4	184	1	0	0	0	0	1	0	0	0	9485	536	19	1	10	1	MED14	23	40511065	Missense_Mutation	SNP	C	TCGA-CV-5976-01A-11D-1683-08	4517081	40511065	114759495	92	34367											
SDF4	51150	broad.mit.edu	37	chr1	1164118	1164118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagccagaggcagcacggaGccaggccaatgaggggaccc	11	1	17	12	1	0	2	0	1	0	1	0	5	0	5	4	6	3	2	4	6	1	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:1164118G>A	uc001adh.3	-	2	385	c.56C>T	c.(55-57)GCT>GTT	p.A19V	SDF4_uc001adi.3_Missense_Mutation_p.A19V|SDF4_uc009vjv.2_Intron|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	19					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding	p.A19V(1)		upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		GCAGCACGGAGCCAGGCCAAT	0.692													6	16					0	0	0	0	A	1164118	A	A	1164118	3	1	185	1	0	0	0	0	1	0	0	0	14027	971	34	4	1172	4	SDF4	1	1164118	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08		1164118	248086503	1	34368											
EPHA8	2046	broad.mit.edu	37	chr1	22902848	22902848	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgcccggcgcgtctatgctGagatcaagtttaccctgcgc	6	9	12	14	5	2	1	1	1	1	1	2	2	2	1	2	1	3	2	2	1	3	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:22902848G>A	uc001bfx.1	+	3	423	c.298G>A	c.(298-300)GAG>AAG	p.E100K	EPHA8_uc001bfw.2_Missense_Mutation_p.E100K	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	100	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CGTCTATGCTGAGATCAAGTT	0.612													11	54					0	0	0	0	A	22902848	A	A	22902848	3	1	185	1	0	0	0	0	1	0	0	0	5197	1291	45	2	308	2	EPHA8	1	22902848	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	21738730	22902848	226347773	2	34369											
COL16A1	1307	broad.mit.edu	37	chr1	32118423	32118423	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccattggtcctgttgcaccCatcttgccatagcctggagg	6	11	10	14	0	1	0	0	0	1	0	2	1	2	1	5	3	3	2	5	3	1	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:32118423C>T	uc001btk.1	-	71	5009	c.4644G>A	c.(4642-4644)ATG>ATA	p.M1548I	COL16A1_uc001bti.1_Missense_Mutation_p.M162I|COL16A1_uc001btj.1_Missense_Mutation_p.M1346I	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	1548	Triple-helical region 1 (COL1) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CTGTTGCACCCATCTTGCCAT	0.592													9	25					0	0	0	0	T	32118423	T	T	32118423	3	4	185	1	0	0	0	0	1	0	0	0	3688	594	21	4	174	4	COL16A1	1	32118423	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	9215575	32118423	217132198	3	34370											
C1orf173	127254	broad.mit.edu	37	chr1	75072310	75072310	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaaagtattttcctggtcGtcttccaagacttcttgtcc	7	18	6	10	1	2	1	0	0	2	1	6	1	5	1	3	1	0	1	3	1	4	8			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:75072310G>A	uc001dgg.2	-	10	1683	c.1464C>T	c.(1462-1464)GAC>GAT	p.D488D	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.D282D	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	488	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TTTCCTGGTCGTCTTCCAAGA	0.358													70	50					0	0	0	0	A	75072310	A	A	75072310	2	1	185	1	0	0	0	0	0	0	0	1	2023	1136	40	1		1	C1orf173	1	75072310	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	42953887	75072310	174178311	4	34371											
LRRC8D	55144	broad.mit.edu	37	chr1	90398915	90398915	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caagatgggcggacaacaaaCgacatttcctttgggacatc	13	8	10	10	2	0	1	0	0	0	1	2	4	1	3	1	3	2	0	1	3	3	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:90398915C>T	uc001dnm.2	+	3	713	c.288C>T	c.(286-288)AAC>AAT	p.N96N	LRRC8D_uc001dnn.2_Silent_p.N96N	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	96						integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GGACAACAAACGACATTTCCT	0.498													31	10					0	0	0	0	T	90398915	T	T	90398915	2	4	185	1	0	0	0	0	0	0	0	1	9074	535	19	1		1	LRRC8D	1	90398915	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	15326605	90398915	158851706	5	34372											
ABCD3	5825	broad.mit.edu	37	chr1	94953518	94953518	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgaatagttttggctgggcGtgaaatgactagattggccg	9	12	14	6	3	0	3	0	2	0	1	1	4	0	3	1	3	0	2	1	3	4	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:94953518G>A	uc001dqn.3	+	13	1238	c.1136G>A	c.(1135-1137)CGT>CAT	p.R379H	ABCD3_uc010oto.1_Missense_Mutation_p.R403H|ABCD3_uc010otp.1_Missense_Mutation_p.R306H|ABCD3_uc009wdr.2_Intron|ABCD3_uc001dqo.3_Missense_Mutation_p.R67H	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	379					peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		TTGGCTGGGCGTGAAATGACT	0.323													17	72					0	0	0	0	A	94953518	A	A	94953518	3	1	185	1	0	0	0	0	1	0	0	0	62	1145	40	1	1217	1	ABCD3	1	94953518	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	4554603	94953518	154297103	6	34373											
ZNF687	57592	broad.mit.edu	37	chr1	151260525	151260525	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatgcacgtgaacacaaGgacaaggggctcgtcatgca	12	6	12	11	2	1	1	1	1	0	0	2	2	1	2	0	3	4	4	0	3	3	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:151260525G>A	uc001exq.2	+	2	1856	c.1758G>A	c.(1756-1758)AAG>AAA	p.K586K	ZNF687_uc001exp.1_Silent_p.K595K|ZNF687_uc009wmo.2_Silent_p.K586K|ZNF687_uc009wmp.2_Silent_p.K586K	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	586					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTGAACACAAGGACAAGGGGC	0.607													13	53					0	0	0	0	A	151260525	A	A	151260525	2	1	185	1	0	0	0	0	0	0	0	1	18159	991	35	4		4	ZNF687	1	151260525	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	56307007	151260525	97990096	7	34374											
DARC	2532	broad.mit.edu	37	chr1	159175312	159175312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcgaagatgtatggaattCttcctatggtgtgaatgatt	10	16	10	5	1	1	3	0	2	1	1	3	5	2	4	1	2	0	1	1	2	5	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:159175312C>T	uc001fto.2	+	2	323	c.83C>T	c.(82-84)TCT>TTT	p.S28F	DARC_uc001ftp.3_Missense_Mutation_p.S30F	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	28	Extracellular (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					GTATGGAATTCTTCCTATGGT	0.537													11	54					0	0	0	0	T	159175312	T	T	159175312	3	4	185	1	0	0	0	0	1	0	0	0	4257	913	32	2	116	2	DARC	1	159175312	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	7914787	159175312	90075309	8	34375											
ABL2	27	broad.mit.edu	37	chr1	179077623	179077632	+	Frame_Shift_Del	DEL	GAGTGGTTGG	-	-																															gactggcactttgtggttgtGagtggttgggaggacggggg																										TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:179077623_179077632delGAGTGGTTGG	uc001gmj.3	-	12	3057_3066	c.2770_2779delCCAACCACTC	c.(2770-2781)CCAACCACTCACfs	p.P924fs	ABL2_uc010pnf.1_Frame_Shift_Del_p.P821fs|ABL2_uc010png.1_Frame_Shift_Del_p.P800fs|ABL2_uc010pnh.1_Frame_Shift_Del_p.P903fs|ABL2_uc001gmg.3_Frame_Shift_Del_p.P806fs|ABL2_uc001gmi.3_Frame_Shift_Del_p.P909fs|ABL2_uc001gmh.3_Frame_Shift_Del_p.P888fs|ABL2_uc010pne.1_Frame_Shift_Del_p.P785fs	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	924_927	F-actin-binding (By similarity).|Pro-rich.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TTGTGGTTGTGAGTGGTTGGGAGGACGGGG	0.557			T	ETV6	AML								---	---	---								-	179077632	-	-	179077623	7	5	185	1	0	1	0	1	0	0	0	0	93	1290	45	0	773	0	ABL2	1	179077623	Frame_Shift_Del	DEL	GAGTGGTTGG	TCGA-CV-5977-01A-11D-1683-08	19902311	179077623	70172998	9	34376											
NLRP3	114548	broad.mit.edu	37	chr1	247597516	247597516	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacaacgccctcggtgacttCggaatcagacttctgtgtgt	8	11	11	11	3	2	2	1	1	1	1	4	4	2	3	1	2	1	0	1	2	2	2	rs143175395		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:247597516C>T	uc001icr.2	+	7	2577	c.2439C>T	c.(2437-2439)TTC>TTT	p.F813F	NLRP3_uc001ics.2_Silent_p.F813F|NLRP3_uc001icu.2_Silent_p.F813F|NLRP3_uc001icw.2_Silent_p.F756F|NLRP3_uc001icv.2_Silent_p.F756F|NLRP3_uc010pyw.1_Silent_p.F791F	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	813	LRR 3.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCGGTGACTTCGGAATCAGAC	0.567													60	32					0	0	0	0	T	247597516	T	T	247597516	2	4	185	1	0	0	0	0	0	0	0	1	10532	883	31	1		1	NLRP3	1	247597516	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	68519893	247597516	1653105	10	34377											
CYP1B1	1545	broad.mit.edu	37	chr2	38301497	38301497	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaggctttacctggtgaaGaggaggagcagccactgcag	11	6	15	9	0	0	3	0	1	0	2	0	5	0	5	2	4	4	3	2	4	2	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:38301497G>A	uc002rqo.2	-	3	1438	c.1035C>T	c.(1033-1035)CTC>CTT	p.L345L		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	345			L -> F (in POAG).		visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	ACCTGGTGAAGAGGAGGAGCA	0.602													6	16					0	0	0	0	A	38301497	A	A	38301497	2	1	185	1	0	0	0	0	0	0	0	1	4168	929	33	2		2	CYP1B1	2	38301497	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08		38301497	204897876	11	34378											
SMYD5	10322	broad.mit.edu	37	chr2	73447180	73447180	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctggctctcaccgtcagcCtgtgaccactgccttagggc	5	10	11	15	1	3	1	2	1	2	0	4	1	3	1	4	2	2	1	4	2	1	1			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:73447180C>T	uc002siw.2	+	3	236	c.207C>T	c.(205-207)GCC>GCT	p.A69A	SMYD5_uc010yre.1_Intron|SMYD5_uc002six.1_5'Flank	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	69							metal ion binding				0						CACCGTCAGCCTGTGACCACT	0.483													20	27					0	0	0	0	T	73447180	T	T	73447180	2	4	185	1	0	0	0	0	0	0	0	1	14889	695	24	4		4	SMYD5	2	73447180	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	35145683	73447180	169752193	12	34379											
SEMA4F	10505	broad.mit.edu	37	chr2	74902408	74902408	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagtgtttccagctgatggCcaccccctgctggtcactac	6	10	9	16	0	1	1	1	1	0	0	2	1	2	1	5	2	3	3	5	2	1	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:74902408C>T	uc002sna.1	+	10	1380	c.1269C>T	c.(1267-1269)GGC>GGT	p.G423G	SEMA4F_uc010ffq.1_Silent_p.G390G|SEMA4F_uc010ffr.1_Silent_p.G35G|SEMA4F_uc002snb.1_Silent_p.G35G|SEMA4F_uc002snc.1_Silent_p.G268G	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	423	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CAGCTGATGGCCACCCCCTGC	0.587											OREG0014721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	25					0	0	0	0	T	74902408	T	T	74902408	2	4	185	1	0	0	0	0	0	0	0	1	14100	726	26	4		4	SEMA4F	2	74902408	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	1455228	74902408	168296965	13	34380											
NEB	4703	broad.mit.edu	37	chr2	152539188	152539188	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctttacctcattgaggatGtctgaagctcgctttgcctt	6	15	10	10	1	2	2	1	2	1	0	3	3	2	3	2	2	3	3	2	2	2	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:152539188G>A	uc010fnx.2	-	29	3122	c.2931C>T	c.(2929-2931)GAC>GAT	p.D977D		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	977	Nebulin 23.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATTGAGGATGTCTGAAGCTC	0.468													13	10					0	0	0	0	A	152539188	A	A	152539188	2	1	185	1	0	0	0	0	0	0	0	1	10356	1368	48	4		4	NEB	2	152539188	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	77636780	152539188	90660185	14	34381											
TTN	7273	broad.mit.edu	37	chr2	179642181	179642181	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcactgaaattgaagatctGcctgccctgttttgggcaac	10	12	9	10	0	2	3	1	2	1	1	2	3	2	3	2	1	3	2	2	1	3	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:179642181G>T	uc010zfg.1	-	26	4835	c.4611C>A	c.(4609-4611)GGC>GGA	p.G1537G	TTN_uc010zfh.1_Silent_p.G1491G|TTN_uc010zfi.1_Silent_p.G1491G|TTN_uc010zfj.1_Silent_p.G1491G|TTN_uc002unb.2_Silent_p.G1537G|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1537							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGAAGATCTGCCTGCCCTGT	0.363													10	25					6.42651e-13	7.22319e-13	1	0	T	179642181	T	T	179642181	2	4	185	1	0	0	0	0	0	0	0	1	16803	1306	46	4		4	TTN	2	179642181	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	27102993	179642181	63557192	15	34382											
TTN	7273	broad.mit.edu	37	chr2	179647599	179647599	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagcactgcaagtaaatcGcccgctgtcttccgcaaatg	11	9	8	13	3	1	0	0	0	1	0	3	0	2	0	2	0	3	5	2	0	5	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:179647599G>A	uc010zfg.1	-	18	3258	c.3034C>T	c.(3034-3036)CGA>TGA	p.R1012*	TTN_uc010zfh.1_Nonsense_Mutation_p.R966*|TTN_uc010zfi.1_Nonsense_Mutation_p.R966*|TTN_uc010zfj.1_Nonsense_Mutation_p.R966*|TTN_uc002unb.2_Nonsense_Mutation_p.R1012*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1012							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R1012*(2)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGTAAATCGCCCGCTGTCT	0.502													20	29					0	0	0	0	A	179647599	A	A	179647599	4	1	185	1	0	0	0	0	0	1	0	0	16803	1095	38	1	108334	1	TTN	2	179647599	Nonsense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	5418	179647599	63551774	16	34383											
PER2	8864	broad.mit.edu	37	chr2	239180022	239180022	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actgtggaacacgcccacatCgtgaggcgccaggaactcca	11	5	11	14	3	0	1	0	1	0	0	2	3	1	3	3	3	2	0	3	3	2	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:239180022C>T	uc002vyc.2	-	6	940	c.703G>A	c.(703-705)GAT>AAT	p.D235N	PER2_uc010znv.1_Missense_Mutation_p.D235N|PER2_uc010znw.1_Missense_Mutation_p.D235N|PER2_uc010fyx.1_Missense_Mutation_p.D235N	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	235	PAS 1.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		ACGCCCACATCGTGAGGCGCC	0.522													19	64					0	0	0	0	T	239180022	T	T	239180022	3	4	185	1	0	0	0	0	1	0	0	0	11784	884	31	1	3136	1	PER2	2	239180022	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	59532423	239180022	4019351	17	34384											
SETD5	55209	broad.mit.edu	37	chr3	9489625	9489625	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattaacagggtctgacccaActgtggtgtcaattactgga	11	11	10	9	0	2	1	1	1	1	0	2	2	2	2	1	3	3	0	1	3	4	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:9489625A>G	uc003brt.2	+	15	2473	c.2038A>G	c.(2038-2040)ACT>GCT	p.T680A	SETD5_uc003brs.1_Missense_Mutation_p.T661A|SETD5_uc003bru.2_Missense_Mutation_p.T582A|SETD5_uc003brv.2_Missense_Mutation_p.T569A|SETD5_uc010hck.2_Missense_Mutation_p.T162A|SETD5_uc003brx.2_Missense_Mutation_p.T349A	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	680										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		GTCTGACCCAACTGTGGTGTC	0.443													2	10					0	0	0	0	G	9489625	G	G	9489625	3	3	185	1	0	0	0	0	1	0	0	0	14199	43	2	5	2088	5	SETD5	3	9489625	Missense_Mutation	SNP	A	TCGA-CV-5977-01A-11D-1683-08		9489625	188532805	18	34385											
ITIH1	3697	broad.mit.edu	37	chr3	52819104	52819104	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccctgctggtggatgtggaTttgcagtacccccaggatgc	6	10	13	12	0	0	0	0	0	0	0	0	3	0	3	4	4	4	3	4	4	1	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:52819104T>C	uc003dfs.2	+	12	1476	c.1452T>C	c.(1450-1452)GAT>GAC	p.D484D	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Silent_p.D85D|ITIH1_uc010hmo.1_Silent_p.D38D|ITIH1_uc003dfu.2_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	484	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TGGATGTGGATTTGCAGTACC	0.562													22	44					0	0	0	0	C	52819104	C	C	52819104	2	2	185	1	0	0	0	0	0	0	0	1	7942	1490	52	5		5	ITIH1	3	52819104	Silent	SNP	T	TCGA-CV-5977-01A-11D-1683-08	43329479	52819104	145203326	19	34386											
TMPRSS7	344805	broad.mit.edu	37	chr3	111794206	111794206	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgcccttcaccgcatcatcGgaggcacagacaccctggag	9	5	10	17	3	2	1	2	0	0	1	3	3	2	3	4	3	0	2	4	3	0	1			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:111794206G>C	uc010hqb.2	+	13	1614	c.1444G>C	c.(1444-1446)GGA>CGA	p.G482R	TMPRSS7_uc011bhr.1_Missense_Mutation_p.G337R	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	608	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						CCGCATCATCGGAGGCACAGA	0.552													7	180					0	0	0	0	C	111794206	C	C	111794206	3	2	185	1	0	0	0	0	1	0	0	0	16318	1117	39	3	1490	3	TMPRSS7	3	111794206	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	58975102	111794206	86228224	20	34387											
CHST2	9435	broad.mit.edu	37	chr3	142841109	142841109	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaggccgccaatgcctggcGgaccgccctcaccttccagc	6	5	11	19	3	1	0	1	0	0	0	2	1	2	1	7	3	2	1	7	3	1	1			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:142841109G>A	uc003evm.2	+	2	2340	c.1451G>A	c.(1450-1452)CGG>CAG	p.R484Q		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	484	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						AATGCCTGGCGGACCGCCCTC	0.612													6	67					0	0	0	0	A	142841109	A	A	142841109	3	1	185	1	0	0	0	0	1	0	0	0	3419	1116	39	1	1453	1	CHST2	3	142841109	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	31046903	142841109	55181321	21	34388											
TTC14	151613	broad.mit.edu	37	chr3	180322057	180322057	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccttctcacagtaaccatggGgatcctttatcatattacca	11	13	5	12	0	2	0	2	0	1	0	4	1	3	1	4	2	2	1	4	2	4	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:180322057G>A	uc003fkk.2	+	4	663	c.531G>A	c.(529-531)GGG>GGA	p.G177G	TTC14_uc003fkl.2_Silent_p.G177G|TTC14_uc003fkm.2_Silent_p.G177G	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	177	S1 motif.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GTAACCATGGGGATCCTTTAT	0.323													66	56					0	0	0	0	A	180322057	A	A	180322057	2	1	185	1	0	0	0	0	0	0	0	1	16749	1219	43	4		4	TTC14	3	180322057	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	37480948	180322057	17700373	22	34389											
C3orf21	152002	broad.mit.edu	37	chr3	194947478	194947478	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggcgaccgagaggaagaaGatggagtcactgtagtaggt	13	7	16	5	2	1	3	1	0	0	3	1	7	1	5	1	4	0	2	1	4	4	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:194947478G>A	uc003fum.3	-	2	720	c.612C>T	c.(610-612)ATC>ATT	p.I204I	C3orf21_uc011bsw.1_Silent_p.I58I	NM_152531	NP_689744	Q8NBI6	CC021_HUMAN	hypothetical protein LOC152002	204						integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)		AGAGGAAGAAGATGGAGTCAC	0.537													8	67					0	0	0	0	A	194947478	A	A	194947478	2	1	185	1	0	0	0	0	0	0	0	1	2224	932	33	2		2	C3orf21	3	194947478	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	14625421	194947478	3074952	23	34390											
RNF168	165918	broad.mit.edu	37	chr3	196199094	196199094	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttcttgtttatgtctctCaaacagtagatgctccaaat	10	17	5	9	0	4	1	1	0	3	1	6	1	5	1	1	0	2	3	1	0	4	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:196199094C>G	uc003fwq.2	-	6	1850	c.1312G>C	c.(1312-1314)GAG>CAG	p.E438Q	RNF168_uc010iah.2_Missense_Mutation_p.E271Q|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	438					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		TTATGTCTCTCAAACAGTAGA	0.413													48	195					0	0	0	0	G	196199094	G	G	196199094	3	3	185	1	0	0	0	0	1	0	0	0	13524	835	29	2	407	2	RNF168	3	196199094	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	1251616	196199094	1823336	24	34391											
GUF1	60558	broad.mit.edu	37	chr4	44688655	44688655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaaggagataaaattgtatCtgcacatactcaaaagacat	19	9	6	7	0	2	2	1	0	1	2	2	3	2	2	0	1	2	2	0	1	7	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr4:44688655C>T	uc003gww.3	+	8	1070	c.863C>T	c.(862-864)TCT>TTT	p.S288F	GUF1_uc010ifz.1_RNA	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	288					translation	mitochondrial inner membrane	GTP binding|GTPase activity	p.S288F(1)		upper_aerodigestive_tract(1)	1						AAAATTGTATCTGCACATACT	0.363													15	90					0	0	0	0	T	44688655	T	T	44688655	3	4	185	1	0	0	0	0	1	0	0	0	6938	913	32	2	893	2	GUF1	4	44688655	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08		44688655	146465621	25	34392											
USP53	54532	broad.mit.edu	37	chr4	120213723	120213723	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgaacagtaatgaaccatCttcattatggtcttcacacc	13	12	6	10	0	4	2	2	2	2	0	4	2	4	2	2	1	2	1	2	1	4	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr4:120213723C>T	uc003ics.3	+	18	3645	c.2579C>T	c.(2578-2580)TCT>TTT	p.S860F	USP53_uc003icr.3_Missense_Mutation_p.S860F|USP53_uc003icu.3_Missense_Mutation_p.S483F	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	860					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						AATGAACCATCTTCATTATGG	0.388													18	42					0	0	0	0	T	120213723	T	T	120213723	3	4	185	1	0	0	0	0	1	0	0	0	17152	913	32	2	2637	2	USP53	4	120213723	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	75525068	120213723	70940553	26	34393											
FAT4	79633	broad.mit.edu	37	chr4	126240974	126240974	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gggccaaatggagaagtaagGtattcttttgaaatggtgca	13	11	13	4	0	1	2	0	1	1	1	1	3	1	2	1	4	1	3	1	4	5	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr4:126240974G>C	uc003ifj.3	+	1	3408	c.3408G>C	c.(3406-3408)AGG>AGC	p.R1136S		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1136	Cadherin 11.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GAGAAGTAAGGTATTCTTTTG	0.433													29	131					0	0	0	0	C	126240974	C	C	126240974	3	2	185	1	0	0	0	0	1	0	0	0	5724	1252	44	4	3410	4	FAT4	4	126240974	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	6027251	126240974	64913302	27	34394											
KIAA0922	23240	broad.mit.edu	37	chr4	154542878	154542878	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcttgtgtgcagtgactttGagaggtctgagctgagcagt	8	12	15	6	0	1	4	0	4	1	1	1	5	1	4	0	1	4	4	0	1	0	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr4:154542878G>C	uc003inm.3	+	28	3785	c.3733G>C	c.(3733-3735)GAG>CAG	p.E1245Q	KIAA0922_uc010ipp.2_Missense_Mutation_p.E1246Q|KIAA0922_uc010ipq.2_Missense_Mutation_p.E1014Q	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1245	Cytoplasmic (Potential).					integral to membrane		p.E1098Q(1)		upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CAGTGACTTTGAGAGGTCTGA	0.428													7	27					0	0	0	0	C	154542878	C	C	154542878	3	2	185	1	0	0	0	0	1	0	0	0	8240	1291	45	2	3846	2	KIAA0922	4	154542878	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	28301904	154542878	36611398	28	34395											
ATG10	83734	broad.mit.edu	37	chr5	81549160	81549160	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactatatcacatcatggctGagcattgtagggccagttgt	11	12	10	8	0	2	1	2	1	0	0	2	1	2	1	1	2	2	4	1	2	4	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:81549160G>C	uc003khs.2	+	8	1008	c.579G>C	c.(577-579)CTG>CTC	p.L193L	ATG10_uc003khr.2_Silent_p.L193L|ATG10_uc010jas.2_Silent_p.L157L	NM_001131028	NP_001124500	Q9H0Y0	ATG10_HUMAN	APG10 autophagy 10-like	193					autophagy in response to ER overload|positive regulation of protein modification process|protein lipidation|protein modification by small protein conjugation|protein transport	cytoplasm	Atg12 ligase activity|protein binding				0		Lung NSC(167;0.0258)|all_lung(232;0.0294)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;9.94e-41)|Epithelial(54;6.3e-36)|all cancers(79;2.31e-30)		CATCATGGCTGAGCATTGTAG	0.413													14	57					0	0	0	0	C	81549160	C	C	81549160	2	2	185	1	0	0	0	0	0	0	0	1	1091	1277	45	2		2	ATG10	5	81549160	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08		81549160	99366100	29	34396											
IL3	3562	broad.mit.edu	37	chr5	131398259	131398259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggccacggccgcacccaCggtaagctgtcccccaagat	8	5	10	18	3	0	1	0	0	0	1	1	1	1	1	6	3	1	3	6	3	2	1			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:131398259C>T	uc003kwe.1	+	4	388	c.335C>T	c.(334-336)ACG>ATG	p.T112M		NM_000588	NP_000579	P08700	IL3_HUMAN	interleukin 3 precursor	112					cell-cell signaling|immune response|nervous system development|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of survival gene product expression|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|growth factor activity|interleukin-3 receptor binding			ovary(2)|central_nervous_system(1)	3		all_cancers(142;7.42e-12)|Lung NSC(810;4.25e-07)|all_lung(232;1.93e-06)|Prostate(281;0.00741)|Breast(839;0.0544)|Lung SC(612;0.122)|Ovarian(839;0.223)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.0161)|Lung(113;0.105)	Amlexanox(DB01025)	GCCGCACCCACggtaagctgt	0.308											OREG0016762	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	137					0	0	0	0	T	131398259	T	T	131398259	3	4	185	1	0	0	0	0	1	0	0	0	7728	550	19	1	349	1	IL3	5	131398259	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	49849099	131398259	49517001	30	34397											
PCDHB8	56128	broad.mit.edu	37	chr5	140559041	140559041	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcacatcggcagcgtcagcGccacagacagagactcgggc	10	4	13	14	4	1	2	1	0	0	2	3	3	1	2	1	2	3	2	1	2	0	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:140559041G>A	uc011dai.1	+	1	1612	c.1426G>A	c.(1426-1428)GCC>ACC	p.A476T	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	476	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGCGTCAGCGCCACAGACAG	0.657													18	122					0	0	0	0	A	140559041	A	A	140559041	3	1	185	1	0	0	0	0	1	0	0	0	11602	1087	38	1	1428	1	PCDHB8	5	140559041	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	9160782	140559041	40356219	31	34398											
PCDHGA6	56109	broad.mit.edu	37	chr5	140755613	140755613	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacggccagccccctctcTccgccactgtcacgctcacc	6	6	6	23	3	3	0	2	0	1	0	5	0	4	0	7	1	1	1	7	1	0	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:140755613T>G	uc003ljy.1	+	1	1963	c.1963T>G	c.(1963-1965)TCC>GCC	p.S655A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.S655A	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	655	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCCCTCTCTCCGCCACTGT	0.706													11	33					0	0	0	0	G	140755613	G	G	140755613	3	3	185	1	0	0	0	0	1	0	0	0	11612	1551	54	5	1965	5	PCDHGA6	5	140755613	Missense_Mutation	SNP	T	TCGA-CV-5977-01A-11D-1683-08	196572	140755613	40159647	32	34399											
PCDHGA7	56108	broad.mit.edu	37	chr5	140764535	140764535	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttacaactatgacctcaCgttgtacctggtggtggcgg	7	12	11	11	2	1	1	1	1	0	0	2	1	2	1	3	4	3	2	3	4	4	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:140764535C>T	uc003lka.1	+	1	2069	c.2069C>T	c.(2068-2070)ACG>ATG	p.T690M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGB4_uc003lkc.1_5'Flank|PCDHGA7_uc003ljz.1_Missense_Mutation_p.T690M|PCDHGB4_uc011dav.1_5'Flank	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	690	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATGACCTCACGTTGTACCTG	0.632													27	27					0	0	0	0	T	140764535	T	T	140764535	3	4	185	1	0	0	0	0	1	0	0	0	11613	536	19	1	2071	1	PCDHGA7	5	140764535	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	8922	140764535	40150725	33	34400											
GABRG2	2566	broad.mit.edu	37	chr5	161569195	161569195	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatgtggtcatgtctgtctaCtttgatctgagcagaagaat	10	15	10	6	0	4	4	1	2	3	2	4	4	4	4	0	1	2	1	0	1	4	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:161569195C>G	uc003lyz.3	+	7	1153	c.795C>G	c.(793-795)TAC>TAG	p.Y265*	GABRG2_uc010jjc.2_Nonsense_Mutation_p.Y305*|GABRG2_uc003lyy.3_Nonsense_Mutation_p.Y265*|GABRG2_uc011dej.1_Nonsense_Mutation_p.Y170*	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	265	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		TGTCTGTCTACTTTGATCTGA	0.403													4	128					0	0	0	0	G	161569195	G	G	161569195	4	3	185	1	0	0	0	0	0	1	0	0	6206	576	20	4	945	4	GABRG2	5	161569195	Nonsense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	20804660	161569195	19346065	34	34401											
WWC1	23286	broad.mit.edu	37	chr5	167896016	167896016	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagctctctctgcagatgaCgtctaatcgccagaaaagta	12	9	8	12	2	3	3	0	1	3	2	5	3	3	3	2	0	2	3	2	0	4	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:167896016C>T	uc003lzu.2	+	23	3429	c.3336C>T	c.(3334-3336)GAC>GAT	p.D1112D	WWC1_uc003lzv.2_Silent_p.D1117D|WWC1_uc011den.1_Silent_p.D1118D|WWC1_uc003lzw.2_Silent_p.D910D	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	1112	ADDV motif.|Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CTGCAGATGACGTCTAATCGC	0.418													8	24					0	0	0	0	T	167896016	T	T	167896016	2	4	185	1	0	0	0	0	0	0	0	1	17479	535	19	1		1	WWC1	5	167896016	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	6326821	167896016	13019244	35	34402											
GRM6	2916	broad.mit.edu	37	chr5	178416069	178416069	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgggcaatggcgtacacCgcatcaatcacaaactgcac	12	6	10	13	3	2	0	2	0	0	0	2	0	2	0	1	2	3	4	1	2	4	1			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:178416069C>T	uc003mjr.2	-	6	1400	c.1221G>A	c.(1219-1221)GCG>GCA	p.A407A	GRM6_uc010jla.1_Intron|GRM6_uc003mjs.1_Silent_p.A27A	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	407	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TGGCGTACACCGCATCAATCA	0.647													4	17					0	0	0	0	T	178416069	T	T	178416069	2	4	185	1	0	0	0	0	0	0	0	1	6840	639	23	1		1	GRM6	5	178416069	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	10520053	178416069	2499191	36	34403											
GRM4	2914	broad.mit.edu	37	chr6	34101144	34101144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgatgtccccatctatgcGgatggaattcatgtgagggt	8	13	13	7	1	2	2	1	2	1	0	3	4	3	4	2	3	1	0	2	3	2	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr6:34101144G>A	uc003oir.3	-	1	300	c.130C>T	c.(130-132)CGC>TGC	p.R44C	GRM4_uc011dsn.1_Missense_Mutation_p.R44C|GRM4_uc010jvh.2_Missense_Mutation_p.R44C|GRM4_uc010jvi.2_5'UTR|GRM4_uc010jvk.1_Intron	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	44	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.R44C(2)		lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	CCATCTATGCGGATGGAATTC	0.612													9	27					0	0	0	0	A	34101144	A	A	34101144	3	1	185	1	0	0	0	0	1	0	0	0	6838	1116	39	1	2648	1	GRM4	6	34101144	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08		34101144	137013923	37	34404											
GPR116	221395	broad.mit.edu	37	chr6	46846093	46846093	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcataacatctattttcttCttgcactcatattcaaaaat	13	16	3	9	0	5	0	2	0	3	0	5	0	5	0	0	1	2	2	0	1	5	8			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr6:46846093C>T	uc003oyo.3	-	10	1375	c.1086G>A	c.(1084-1086)AAG>AAA	p.K362K	GPR116_uc003oyp.3_Intron|GPR116_uc003oyq.3_Silent_p.K362K|GPR116_uc010jzi.1_Silent_p.K34K|GPR116_uc003oyr.2_Silent_p.K362K	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	362	Ig-like 1.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CTATTTTCTTCTTGCACTCAT	0.328													9	35					0	0	0	0	T	46846093	T	T	46846093	2	4	185	1	0	0	0	0	0	0	0	1	6671	912	32	2		2	GPR116	6	46846093	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	12744949	46846093	124268974	38	34405											
HCRTR2	3062	broad.mit.edu	37	chr6	55113499	55113499	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaactacttcatagtcaatCtttctctggctgatgtgctc	8	15	6	12	0	4	1	2	1	2	0	6	1	4	1	1	1	3	2	1	1	4	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr6:55113499C>G	uc003pcl.2	+	2	601	c.286C>G	c.(286-288)CTT>GTT	p.L96V	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.L31V	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	96	Helical; Name=2; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity	p.L96V(2)		ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CATAGTCAATCTTTCTCTGGC	0.458													76	95					0	0	0	0	G	55113499	G	G	55113499	3	3	185	1	0	0	0	0	1	0	0	0	7041	913	32	2	292	2	HCRTR2	6	55113499	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	8267406	55113499	116001568	39	34406											
KIAA0415	9907	broad.mit.edu	37	chr7	4825265	4825265	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcgggtgcgcggggaccCggcctctgtgcgggtgctgc	1	6	21	13	6	1	0	0	0	1	0	1	1	1	1	2	6	4	1	2	6	0	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:4825265C>T	uc003sne.2	+	9	1165	c.1082C>T	c.(1081-1083)CCG>CTG	p.P361L	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_5'Flank	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	361					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		CGCGGGGACCCGGCCTCTGTG	0.697													5	2					0	0	0	0	T	4825265	T	T	4825265	3	4	185	1	0	0	0	0	1	0	0	0	8214	652	23	1	1116	1	KIAA0415	7	4825265	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08		4825265	154313398	40	34407											
FBXL18	80028	broad.mit.edu	37	chr7	5540952	5540952	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggctgaaactgaagtagaaCgggttgttgaatttcatgtg	11	12	13	5	2	1	4	1	3	0	1	1	4	1	4	0	2	2	4	0	2	5	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:5540952C>T	uc003soo.2	-	3	1042	c.948G>A	c.(946-948)CCG>CCA	p.P316P	FBXL18_uc003son.3_Silent_p.P316P	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	316										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		TGAAGTAGAACGGGTTGTTGA	0.597													12	15					0	0	0	0	T	5540952	T	T	5540952	2	4	185	1	0	0	0	0	0	0	0	1	5746	523	19	1		1	FBXL18	7	5540952	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	715687	5540952	153597711	41	34408											
PCLO	27445	broad.mit.edu	37	chr7	82579315	82579315	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgttcttatggttccaactGgttcagtttgcacagatatc	8	16	9	8	0	2	1	1	0	1	1	4	1	3	1	1	2	2	5	1	2	3	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:82579315G>A	uc003uhx.2	-	6	10878	c.10589C>T	c.(10588-10590)CCA>CTA	p.P3530L	PCLO_uc003uhv.2_Missense_Mutation_p.P3530L|PCLO_uc010lec.2_Missense_Mutation_p.P495L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3461					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGTTCCAACTGGTTCAGTTTG	0.463													13	21					0	0	0	0	A	82579315	A	A	82579315	3	1	185	1	0	0	0	0	1	0	0	0	11637	1348	47	4	4936	4	PCLO	7	82579315	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	77038363	82579315	76559348	42	34409											
COL1A2	1278	broad.mit.edu	37	chr7	94056511	94056511	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccttagggccctgctggTccttctggccctgctggaaa	4	12	11	14	0	1	0	0	0	1	0	3	1	3	1	4	4	2	2	4	4	2	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:94056511T>C	uc003ung.1	+	48	3642	c.3171T>C	c.(3169-3171)GGT>GGC	p.G1057G	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1057					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GCCCTGCTGGTCCTTCTGGCC	0.587										HNSCC(75;0.22)			7	12					0	0	0	0	C	94056511	C	C	94056511	2	2	185	1	0	0	0	0	0	0	0	1	3693	1654	58	5		5	COL1A2	7	94056511	Silent	SNP	T	TCGA-CV-5977-01A-11D-1683-08	11477196	94056511	65082152	43	34410											
CYP3A4	1576	broad.mit.edu	37	chr7	99364768	99364768	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttaccttttgtgtatcttCgaggcgactttctttcatcc	5	20	6	10	2	3	0	1	0	2	0	5	2	4	0	2	1	1	1	2	1	2	8			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:99364768C>T	uc003urv.1	-	8	888	c.784G>A	c.(784-786)GAA>AAA	p.E262K	CYP3A4_uc003urw.1_Missense_Mutation_p.E261K|CYP3A4_uc011kiz.1_Missense_Mutation_p.E221K|CYP3A4_uc011kja.1_Missense_Mutation_p.E213K|CYP3A4_uc011kjb.1_Missense_Mutation_p.E112K	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	262					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TGTGTATCTTCGAGGCGACTT	0.308													16	33					0	0	0	0	T	99364768	T	T	99364768	3	4	185	1	0	0	0	0	1	0	0	0	4195	893	31	1	751	1	CYP3A4	7	99364768	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	5308257	99364768	59773895	44	34411											
PTN	5764	broad.mit.edu	37	chr7	136938277	136938277	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcatggtttgcttgcactCagctccagtccgagtgccct	5	13	9	14	1	2	0	2	0	0	0	4	1	4	0	3	1	4	4	3	1	0	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:136938277C>G	uc003vtq.2	-	3	586	c.223G>C	c.(223-225)GAG>CAG	p.E75Q	PTN_uc010lmx.2_Missense_Mutation_p.E75Q|PTN_uc003vtr.1_Missense_Mutation_p.E75Q	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	75				E -> G (in Ref. 9; AAV38498).	nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity	p.E75Q(1)		upper_aerodigestive_tract(1)|pancreas(1)	2						TGCTTGCACTCAGCTCCAGTC	0.537													11	53					0	0	0	0	G	136938277	G	G	136938277	3	3	185	1	0	0	0	0	1	0	0	0	12831	835	29	2	295	2	PTN	7	136938277	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	37573509	136938277	22200386	45	34412											
CSMD1	64478	broad.mit.edu	37	chr8	3611465	3611465	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccttaccttggaactgagcGttaaatcctttgcgtcggtg	7	14	10	10	3	0	1	0	1	0	0	3	2	2	2	3	2	4	1	3	2	4	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr8:3611465G>A	uc011kwk.1	-	6	1308	c.918C>T	c.(916-918)AAC>AAT	p.N306N		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	306	Extracellular (Potential).|CUB 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGAACTGAGCGTTAAATCCTT	0.418													19	8					0	0	0	0	A	3611465	A	A	3611465	2	1	185	1	0	0	0	0	0	0	0	1	3961	1136	40	1		1	CSMD1	8	3611465	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08		3611465	142752557	46	34413											
MTUS1	57509	broad.mit.edu	37	chr8	17611496	17611496	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttcctgattcgatttcacGgcagatgttgttcttggaac	7	16	9	9	2	3	2	1	1	2	1	5	4	4	3	1	2	1	3	1	2	1	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr8:17611496G>T	uc003wxv.2	-	2	2295	c.1821C>A	c.(1819-1821)GCC>GCA	p.A607A	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Silent_p.A607A|MTUS1_uc010lsz.2_Silent_p.A607A	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	607						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		TCGATTTCACGGCAGATGTTG	0.433													109	35					4.07119e-57	4.77312e-57	1	0	T	17611496	T	T	17611496	2	4	185	1	0	0	0	0	0	0	0	1	10018	1103	39	3		3	MTUS1	8	17611496	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	14000031	17611496	128752526	47	34414											
ADCY8	114	broad.mit.edu	37	chr8	131880186	131880186	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaacacttcatccctcatttGagaatactgtaattaaaaaa	17	12	4	8	0	2	1	2	1	0	1	3	3	3	1	1	0	2	1	1	0	7	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr8:131880186G>C	uc003ytd.3	-	9	2372	c.2116C>G	c.(2116-2118)CAA>GAA	p.Q706E	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	706	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TCCCTCATTTGAGAATACTGT	0.358										HNSCC(32;0.087)			19	61					0	0	0	0	C	131880186	C	C	131880186	3	2	185	1	0	0	0	0	1	0	0	0	300	1299	45	2	1679	2	ADCY8	8	131880186	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	114268690	131880186	14483836	48	34415											
TG	7038	broad.mit.edu	37	chr8	133978854	133978854	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctcaaccaggtcattgtCaatggaaatcaatcactatc	14	10	6	11	0	5	0	5	0	0	0	6	2	5	1	2	2	1	0	2	2	5	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr8:133978854C>A	uc003ytw.2	+	30	5639	c.5598C>A	c.(5596-5598)GTC>GTA	p.V1866V	TG_uc010mdw.2_Silent_p.V625V|TG_uc011ljb.1_Silent_p.V235V|TG_uc011ljc.1_Silent_p.V20V|TG_uc010mdx.1_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1866	Type IIIB.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGGTCATTGTCAATGGAAATC	0.453													47	96					3.21987e-24	3.71104e-24	1	0	A	133978854	A	A	133978854	2	1	185	1	0	0	0	0	0	0	0	1	15879	813	29	2		2	TG	8	133978854	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	2098668	133978854	12385168	49	34416											
CDKN2A	1029	broad.mit.edu	37	chr9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcagctccgccactcGggcgctgcccatcatcatga	8	6	10	17	3	2	1	2	1	0	0	4	1	3	1	3	1	4	4	3	1	0	0	rs121913387		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	1					0	0	0	0	A	21971186	A	A	21971186	4	1	185	1	0	0	0	0	0	1	0	0	3176	1125	39	1	306	1	CDKN2A	9	21971186	Nonsense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08		21971186	119242245	50	34417											
FLJ46321	389763	broad.mit.edu	37	chr9	84608276	84608276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agatggggtctctaagtcccGtagtcgaagcacttttcaag	10	11	11	9	2	2	1	1	0	1	1	5	2	3	1	1	2	1	2	1	2	4	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:84608276G>A	uc004amn.2	+	4	2938	c.2891G>A	c.(2890-2892)CGT>CAT	p.R964H		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	964						integral to membrane					0						TCTAAGTCCCGTAGTCGAAGC	0.517													47	90					0	0	0	0	A	84608276	A	A	84608276	3	1	185	1	0	0	0	0	1	0	0	0	5964	1145	40	1	2905	1	FLJ46321	9	84608276	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	62637090	84608276	56605155	51	34418											
ZNF883	169834	broad.mit.edu	37	chr9	115760008	115760008	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttacactggtaggatttttCctcagaatgaattccctgat	10	15	7	9	0	1	3	1	2	0	1	3	4	3	4	2	2	1	1	2	2	4	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:115760008C>T	uc011lwy.1	-	5	1771	c.532G>A	c.(532-534)GAA>AAA	p.E178K		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGGATTTTTCCTCAGAATGA	0.403													21	27					0	0	0	0	T	115760008	T	T	115760008	3	4	185	1	0	0	0	0	1	0	0	0	18265	864	30	2	609	2	ZNF883	9	115760008	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	31151732	115760008	25453423	52	34419											
RGS3	5998	broad.mit.edu	37	chr9	116267802	116267802	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagtccaggccgtggattcCggtaagttattgacaggggg	8	9	16	8	3	0	1	0	1	0	0	2	3	2	2	3	5	0	2	3	5	2	4	rs142637936		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:116267802C>T	uc004bhq.2	+	12	1187	c.978C>T	c.(976-978)TCC>TCT	p.S326S	RGS3_uc004bhr.2_Silent_p.S214S|RGS3_uc004bhs.2_Silent_p.S216S|RGS3_uc004bht.2_Silent_p.S45S|RGS3_uc010muy.2_Silent_p.S45S|RGS3_uc004bhu.2_5'UTR	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	326	PDZ.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						CCGTGGATTCCGGTAAGTTAT	0.572													15	19					0	0	0	0	T	116267802	T	T	116267802	2	4	185	1	0	0	0	0	0	0	0	1	13371	666	23	1		1	RGS3	9	116267802	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	507794	116267802	24945629	53	34420											
GSN	2934	broad.mit.edu	37	chr9	124064328	124064328	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgtgtggagaagttcgatCtggtgcccgtgcccaccaac	7	8	14	12	3	1	1	0	0	1	1	2	3	1	1	3	3	3	1	3	3	2	1			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:124064328C>A	uc004blf.1	+	2	293	c.232C>A	c.(232-234)CTG>ATG	p.L78M	GSN_uc004bld.1_Missense_Mutation_p.L27M|GSN_uc010mvq.1_Missense_Mutation_p.L38M|GSN_uc010mvr.1_Missense_Mutation_p.L38M|GSN_uc010mvu.1_Missense_Mutation_p.L27M|GSN_uc010mvt.1_Missense_Mutation_p.L27M|GSN_uc010mvs.1_Missense_Mutation_p.L27M|GSN_uc004ble.1_Missense_Mutation_p.L27M|GSN_uc010mvv.1_Missense_Mutation_p.L27M|GSN_uc011lyh.1_Missense_Mutation_p.L44M|GSN_uc011lyi.1_Missense_Mutation_p.L27M|GSN_uc011lyj.1_Missense_Mutation_p.L51M	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	78	Actin-severing (Potential).|Gelsolin-like 1.				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						GAAGTTCGATCTGGTGCCCGT	0.572													29	112					9.39395e-14	1.06465e-13	1	0	A	124064328	A	A	124064328	3	1	185	1	0	0	0	0	1	0	0	0	6864	912	32	2	266	2	GSN	9	124064328	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	7796526	124064328	17149103	54	34421											
ADAMTS13	11093	broad.mit.edu	37	chr9	136307841	136307841	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagcgtggccagaggcctgCgtgctcgaaccctgccctcc	5	6	12	18	3	0	1	0	0	0	1	2	2	1	1	6	2	5	1	6	2	1	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:136307841C>T	uc004cdv.3	+	18	2655	c.2211C>T	c.(2209-2211)TGC>TGT	p.C737C	ADAMTS13_uc004cdp.3_Intron|ADAMTS13_uc004cdt.1_Silent_p.C737C|ADAMTS13_uc004cdu.1_Silent_p.C706C|ADAMTS13_uc004cdw.3_Silent_p.C737C|ADAMTS13_uc004cdx.3_Silent_p.C706C|ADAMTS13_uc004cdy.1_Intron|ADAMTS13_uc004cdz.3_Silent_p.C407C|ADAMTS13_uc004cds.1_Silent_p.C262C|ADAMTS13_uc004cdr.1_Intron	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	737					cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CAGAGGCCTGCGTGCTCGAAC	0.657													38	31					0	0	0	0	T	136307841	T	T	136307841	2	4	185	1	0	0	0	0	0	0	0	1	258	776	27	1		1	ADAMTS13	9	136307841	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	12243513	136307841	4905590	55	34422											
CAMSAP1	157922	broad.mit.edu	37	chr9	138714065	138714065	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcctctccgcaaagctggtCatcttcacgctcccactcgc	6	11	6	18	3	4	0	2	0	2	0	8	0	6	0	3	1	1	3	3	1	1	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:138714065C>G	uc004cgr.3	-	11	2442	c.2442G>C	c.(2440-2442)ATG>ATC	p.M814I	CAMSAP1_uc004cgq.3_Missense_Mutation_p.M704I|CAMSAP1_uc010nbg.2_Missense_Mutation_p.M536I	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	814						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CAAAGCTGGTCATCTTCACGC	0.587													18	101					0	0	0	0	G	138714065	G	G	138714065	3	3	185	1	0	0	0	0	1	0	0	0	2623	826	29	2	2394	2	CAMSAP1	9	138714065	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	2406224	138714065	2499366	56	34423											
SFMBT2	57713	broad.mit.edu	37	chr10	7205769	7205769	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtagaaagccactttgactCtctcgatctggtggcataac	10	11	9	11	2	2	2	0	1	2	1	4	3	2	2	1	2	2	2	1	2	3	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:7205769C>G	uc009xio.1	-	21	2739	c.2648G>C	c.(2647-2649)AGA>ACA	p.R883T	SFMBT2_uc001ijn.1_Missense_Mutation_p.R883T|SFMBT2_uc010qay.1_Missense_Mutation_p.R718T	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	883	SAM.				regulation of transcription, DNA-dependent	nucleus		p.R883T(1)		ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						CACTTTGACTCTCTCGATCTG	0.567													8	23					0	0	0	0	G	7205769	G	G	7205769	3	3	185	1	0	0	0	0	1	0	0	0	14223	913	32	2	40	2	SFMBT2	10	7205769	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08		7205769	128328978	57	34424											
CELF2	10659	broad.mit.edu	37	chr10	11308601	11308601	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctacaagggcaatggcacaGaatgcaatcaaagccatgca	16	6	9	10	0	2	1	1	0	1	1	2	1	2	1	1	2	4	4	1	2	6	1			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:11308601G>A	uc001iki.3	+	6	650	c.558G>A	c.(556-558)CAG>CAA	p.Q186Q	CELF2_uc010qbi.1_Intron|CELF2_uc010qbj.1_Silent_p.Q186Q|CELF2_uc001ikk.2_Silent_p.Q193Q|CELF2_uc001ikl.3_Silent_p.Q193Q|CELF2_uc010qbk.1_Intron|CELF2_uc010qbl.1_Silent_p.Q162Q|CELF2_uc010qbm.1_Intron|CELF2_uc001iko.3_Silent_p.Q162Q|CELF2_uc001ikp.3_Silent_p.Q162Q|CELF2_uc010qbn.1_Silent_p.Q170Q|CELF2_uc010qbo.1_Silent_p.Q75Q|CELF2_uc010qbp.1_Intron	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	186	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.|RRM 2.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						CAATGGCACAGAATGCAATCA	0.448													11	20					0	0	0	0	A	11308601	A	A	11308601	2	1	185	1	0	0	0	0	0	0	0	1	3231	933	33	2		2	CELF2	10	11308601	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	4102832	11308601	124226146	58	34425											
CUBN	8029	broad.mit.edu	37	chr10	16962010	16962010	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttcaaattgcagctgtatgCgtgtttccggtggagccgct	6	13	12	10	3	1	0	1	0	0	0	2	1	2	1	2	2	4	5	2	2	2	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:16962010C>T	uc001ioo.2	-	44	6825	c.6773G>A	c.(6772-6774)CGC>CAC	p.R2258H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2258	CUB 16.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity	p.R2258H(1)		ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGCTGTATGCGTGTTTCCGG	0.438													8	26					0	0	0	0	T	16962010	T	T	16962010	3	4	185	1	0	0	0	0	1	0	0	0	4068	768	27	1	4194	1	CUBN	10	16962010	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	5653409	16962010	118572737	59	34426											
ZNF488	118738	broad.mit.edu	37	chr10	48370659	48370659	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagcgaacctgagctgggcCggggctgcaagccagtgctg	7	7	16	11	2	0	1	0	1	0	0	0	2	0	1	3	3	6	4	3	3	3	1	rs149252316		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:48370659C>T	uc001jex.2	+	2	289	c.127C>T	c.(127-129)CGG>TGG	p.R43W	ZNF488_uc001jey.2_5'UTR	NM_153034	NP_694579	Q96MN9	ZN488_HUMAN	zinc finger protein 488	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGAGCTGGGCCGGGGCTGCAA	0.677													13	64					0	0	0	0	T	48370659	T	T	48370659	3	4	185	1	0	0	0	0	1	0	0	0	18007	643	23	1	129	1	ZNF488	10	48370659	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	31408649	48370659	87164088	60	34427											
PCDH15	65217	broad.mit.edu	37	chr10	55582486	55582486	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtggagaatgagaagtgaGgcctgggaaagcaaaatgaa	18	5	15	3	0	0	4	0	3	0	2	0	7	0	5	1	3	1	1	1	3	7	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:55582486G>T	uc001jju.1	-	33	5395	c.5000C>A	c.(4999-5001)CCT>CAT	p.P1667H	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.P1664H|PCDH15_uc010qhw.1_Missense_Mutation_p.P1627H|PCDH15_uc010qhx.1_Missense_Mutation_p.P1598H|PCDH15_uc010qhy.1_Missense_Mutation_p.P1674H|PCDH15_uc010qhz.1_Missense_Mutation_p.P1669H|PCDH15_uc010qia.1_Missense_Mutation_p.P1647H|PCDH15_uc010qib.1_Missense_Mutation_p.P1644H	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1667	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.P1674H(1)|p.P1667H(1)		pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGAGAAGTGAGGCCTGGGAAA	0.418										HNSCC(58;0.16)			37	38					7.83172e-31	9.10353e-31	1	0	T	55582486	T	T	55582486	3	4	185	1	0	0	0	0	1	0	0	0	11565	1000	35	4	2477	4	PCDH15	10	55582486	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	7211827	55582486	79952261	61	34428											
RHOBTB1	9886	broad.mit.edu	37	chr10	62632017	62632017	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtgcagatgtggtgcaaaCaccaggcggccaactggtgg	9	7	16	9	1	0	1	0	0	0	1	0	1	0	1	2	6	4	2	2	6	2	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:62632017C>T	uc001jli.2	-	11	2285	c.1847G>A	c.(1846-1848)TGT>TAT	p.C616Y	RHOBTB1_uc001jlh.2_Missense_Mutation_p.C616Y|RHOBTB1_uc001jlj.2_Missense_Mutation_p.C616Y|RHOBTB1_uc001jlk.2_Missense_Mutation_p.C616Y|RHOBTB1_uc009xpe.1_Missense_Mutation_p.C554Y|RHOBTB1_uc009xpd.2_Intron|RHOBTB1_uc001jll.2_Missense_Mutation_p.C366Y	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	616					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					GTGGTGCAAACACCAGGCGGC	0.468													11	53					0	0	0	0	T	62632017	T	T	62632017	3	4	185	1	0	0	0	0	1	0	0	0	13398	478	17	4	251	4	RHOBTB1	10	62632017	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	7049531	62632017	72902730	62	34429											
CYP2C19	1557	broad.mit.edu	37	chr10	96580294	96580294	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaattcactattgaaaacttGgtaatcactgcagctgactt	13	13	7	8	0	2	2	2	2	0	0	2	3	2	2	0	1	3	3	0	1	5	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:96580294G>T	uc010qnz.1	+	6	861	c.861G>T	c.(859-861)TTG>TTT	p.L287F	CYP2C19_uc010qny.1_Missense_Mutation_p.L265F	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	287					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TTGAAAACTTGGTAATCACTG	0.413													12	56					6.40141e-05	6.85505e-05	1	0	T	96580294	T	T	96580294	3	4	185	1	0	0	0	0	1	0	0	0	4183	1339	47	4	883	4	CYP2C19	10	96580294	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	33948277	96580294	38954453	63	34430											
FGFR2	2263	broad.mit.edu	37	chr10	123274743	123274743	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcacaggatgactgttaccAccatacaggcgattaagaag	14	7	11	9	1	0	2	0	1	0	1	0	4	0	3	2	3	2	2	2	3	4	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:123274743A>G	uc010qtk.1	-	9	1822	c.1175T>C	c.(1174-1176)GTG>GCG	p.V392A	FGFR2_uc010qtg.1_Missense_Mutation_p.V280A|FGFR2_uc010qth.1_Missense_Mutation_p.V277A|FGFR2_uc010qti.1_Missense_Mutation_p.V303A|FGFR2_uc010qtj.1_Missense_Mutation_p.V393A|FGFR2_uc010qtl.1_Intron|FGFR2_uc010qtm.1_Missense_Mutation_p.V277A|FGFR2_uc001lfl.3_Missense_Mutation_p.V393A|FGFR2_uc001lfm.2_Missense_Mutation_p.V304A|FGFR2_uc001lfn.3_RNA|FGFR2_uc001lfg.3_Missense_Mutation_p.V2A	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	392	Helical; (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding	p.V392A(1)		endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GACTGTTACCACCATACAGGC	0.522		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				29	37					0	0	0	0	G	123274743	G	G	123274743	3	3	185	1	0	0	0	0	1	0	0	0	5898	159	6	5	1434	5	FGFR2	10	123274743	Missense_Mutation	SNP	A	TCGA-CV-5977-01A-11D-1683-08	26694449	123274743	12260004	64	34431											
DCHS1	8642	broad.mit.edu	37	chr11	6648366	6648366	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggggcctgggcggggcagAcgtaggcgcagaggactggt	6	5	21	9	3	0	2	0	0	0	2	0	3	0	3	1	8	0	3	1	8	1	1			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr11:6648366A>G	uc001mem.1	-	14	6314	c.5904T>C	c.(5902-5904)CGT>CGC	p.R1968R		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1968	Cadherin 19.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCGGGGCAGACGTAGGCGCA	0.612													23	53					0	0	0	0	G	6648366	G	G	6648366	2	3	185	1	0	0	0	0	0	0	0	1	4304	262	10	5		5	DCHS1	11	6648366	Silent	SNP	A	TCGA-CV-5977-01A-11D-1683-08		6648366	128358150	65	34432											
OR4C11	219429	broad.mit.edu	37	chr11	55371152	55371152	+	Frame_Shift_Del	DEL	T	-	-																															acgtgcaagcggagagagccTttttcttccctttggcactg																										TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr11:55371152delT	uc010rii.1	-	1	698	c.698delA	c.(697-699)AAGfs	p.K233fs		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGAGAGAGCCTTTTTCTTCCC	0.418													---	---	---								-	55371152	-	-	55371152	7	5	185	1	0	1	0	1	0	0	0	0	11099	1609	56	0	236	0	OR4C11	11	55371152	Frame_Shift_Del	DEL	T	TCGA-CV-5977-01A-11D-1683-08	48722786	55371152	79635364	66	34433											
CPT1A	1374	broad.mit.edu	37	chr11	68566776	68566776	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcttgagcaagtgctgtcatCcgtttgaagtcttcttcctt	6	17	8	10	1	4	2	1	2	3	0	6	2	6	2	2	0	2	3	2	0	2	5	rs143731699		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr11:68566776C>T	uc001oog.3	-	6	773	c.603G>A	c.(601-603)CGG>CGA	p.R201R	CPT1A_uc001oof.3_Silent_p.R201R|CPT1A_uc009ysj.2_Silent_p.R201R	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	201	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GTGCTGTCATCCGTTTGAAGT	0.393													86	137					0	0	0	0	T	68566776	T	T	68566776	2	4	185	1	0	0	0	0	0	0	0	1	3846	842	30	2		2	CPT1A	11	68566776	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	13195624	68566776	66439740	67	34434											
ATN1	1822	broad.mit.edu	37	chr12	7046142	7046142	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccctccagtctcttcctCttccaactcttcctcttcca	4	15	3	19	0	4	0	0	0	4	0	10	0	9	0	6	1	1	0	6	1	1	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr12:7046142C>A	uc001qrw.1	+	5	1949	c.1712C>A	c.(1711-1713)TCT>TAT	p.S571Y	ATN1_uc001qrx.1_Missense_Mutation_p.S571Y	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	571	Poly-Ser.				cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GTCTCTTCCTCTTCCAACTCT	0.632													15	80					1.15088e-07	1.26225e-07	1	0	A	7046142	A	A	7046142	3	1	185	1	0	0	0	0	1	0	0	0	1113	913	32	2	1726	2	ATN1	12	7046142	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08		7046142	126805753	68	34435											
GYS2	2998	broad.mit.edu	37	chr12	21692267	21692267	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtcaggtgtctggcatgctgGtaatactattgatagaaagc	11	12	12	6	0	2	2	1	1	1	1	2	2	2	2	0	3	3	3	0	3	5	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr12:21692267G>A	uc001rfb.2	-	15	2070	c.1815C>T	c.(1813-1815)TAC>TAT	p.Y605Y		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	605					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						TGGCATGCTGGTAATACTATT	0.328													49	94					0	0	0	0	A	21692267	A	A	21692267	2	1	185	1	0	0	0	0	0	0	0	1	6952	1256	44	4		4	GYS2	12	21692267	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	14646125	21692267	112159628	69	34436											
OSBPL8	114882	broad.mit.edu	37	chr12	76767187	76767187	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtttccctgatatttgattAacacagtcactactccctag	11	14	5	11	0	1	2	1	2	0	0	3	2	3	2	2	0	2	1	2	0	4	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr12:76767187A>G	uc001sye.1	-	18	2334	c.1854T>C	c.(1852-1854)GTT>GTC	p.V618V	OSBPL8_uc001syf.1_Silent_p.V576V|OSBPL8_uc001syg.1_Silent_p.V576V|OSBPL8_uc001syh.1_Silent_p.V593V	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	618					lipid transport		lipid binding			ovary(1)	1						ATATTTGATTAACACAGTCAC	0.294													3	65					0	0	0	0	G	76767187	G	G	76767187	2	3	185	1	0	0	0	0	0	0	0	1	11337	349	13	5		5	OSBPL8	12	76767187	Silent	SNP	A	TCGA-CV-5977-01A-11D-1683-08	55074920	76767187	57084708	70	34437											
ZC3H13	23091	broad.mit.edu	37	chr13	46543408	46543408	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaggagaaggggtactacCaggagtcgtggcggtggcag	10	6	19	6	2	0	2	0	0	0	2	1	4	0	3	1	7	2	2	1	7	4	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr13:46543408C>T	uc010tfw.1	-	13	3277	c.3271G>A	c.(3271-3273)GGT>AGT	p.G1091S	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Missense_Mutation_p.G1091S|ZC3H13_uc001vat.1_Missense_Mutation_p.G1091S	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1091							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		GGGGTACTACCAGGAGTCGTG	0.378													11	40					0	0	0	0	T	46543408	T	T	46543408	3	4	185	1	0	0	0	0	1	0	0	0	17632	594	21	4	1439	4	ZC3H13	13	46543408	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08		46543408	68626470	71	34438											
SUCLA2	8803	broad.mit.edu	37	chr13	48528631	48528631	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccagtcctgtagatcaaaGattttcttttggcgataggc	9	14	10	8	1	2	2	1	0	1	2	4	3	4	2	2	2	0	1	2	2	3	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr13:48528631G>C	uc001vbs.2	-	7	921	c.864C>G	c.(862-864)ATC>ATG	p.I288M	SUCLA2_uc010tgb.1_Missense_Mutation_p.I228M|SUCLA2_uc010tgc.1_Missense_Mutation_p.I154M|SUCLA2_uc010tgd.1_Missense_Mutation_p.I228M|SUCLA2_uc001vbt.1_RNA	NM_003850	NP_003841	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	288	ATP-grasp.				succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)	1		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	GTAGATCAAAGATTTTCTTTT	0.393													13	42					0	0	0	0	C	48528631	C	C	48528631	3	2	185	1	0	0	0	0	1	0	0	0	15429	932	33	2	547	2	SUCLA2	13	48528631	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	1985223	48528631	66641247	72	34439											
SLITRK1	114798	broad.mit.edu	37	chr13	84453707	84453707	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgtctcttggaccgctttcGgttcctcaggataaacacga	8	12	9	12	4	2	0	1	0	1	0	6	3	3	2	2	3	1	2	2	3	2	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr13:84453707G>A	uc001vlk.2	-	1	2822	c.1936C>T	c.(1936-1938)CGA>TGA	p.R646*		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	646	Cytoplasmic (Potential).					integral to membrane		p.R646*(1)		ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GACCGCTTTCGGTTCCTCAGG	0.562													10	15					0	0	0	0	A	84453707	A	A	84453707	4	1	185	1	0	0	0	0	0	1	0	0	14806	1124	39	1	158	1	SLITRK1	13	84453707	Nonsense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	35925076	84453707	30716171	73	34440											
RNASE12	493901	broad.mit.edu	37	chr14	21058491	21058491	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaagtcatcacaagtgacaAgaacaaacccctctgtgggg	14	7	9	11	0	4	2	3	1	1	1	4	2	4	2	2	2	2	0	2	2	5	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr14:21058491A>T	uc001vxt.2	-	1	492	c.392T>A	c.(391-393)CTT>CAT	p.L131H	RNASE11_uc010ahv.2_5'Flank|RNASE11_uc010ahx.2_5'Flank|RNASE11_uc010ahw.2_5'Flank|RNASE11_uc001vxs.2_5'Flank|uc001vxu.1_5'Flank	NM_001024822	NP_001019993	Q5GAN4	RNS12_HUMAN	ribonuclease, RNase A family, 12 (non-active)	131						extracellular region	nucleic acid binding|pancreatic ribonuclease activity	p.L131H(1)		upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(95;0.00238)		Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.013)		ACAAGTGACAAGAACAAACCC	0.463													41	57					0	0	0	0	T	21058491	T	T	21058491	3	4	185	1	0	0	0	0	1	0	0	0	13467	72	3	5	55	5	RNASE12	14	21058491	Missense_Mutation	SNP	A	TCGA-CV-5977-01A-11D-1683-08		21058491	86291049	74	34441											
YY1	7528	broad.mit.edu	37	chr14	100705745	100705749	+	Frame_Shift_Del	DEL	GCGGT	-	-																															cgacgacgacgaggacggcgGcggtggcgaccacggcggcg																										TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr14:100705745_100705749delGCGGT	uc001ygy.1	+	1	644_648	c.164_168delGCGGT	c.(163-168)GGCGGTfs	p.G55fs		NM_003403	NP_003394	P25490	TYY1_HUMAN	YY1 transcription factor	55_56	Gly-rich.				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding				0		Melanoma(154;0.152)				gaggacggcggcggtggcgaccacg	0.298													---	---	---								-	100705749	-	-	100705745	7	5	185	1	0	1	0	1	0	0	0	0	17575	1203	42	0	166	0	YY1	14	100705745	Frame_Shift_Del	DEL	GCGGT	TCGA-CV-5977-01A-11D-1683-08	79647254	100705745	6643795	75	34442											
ACTC1	70	broad.mit.edu	37	chr15	35084363	35084363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatagtgatgacttggccatCaggcagttcatagctcttct	10	13	9	9	0	4	2	2	2	2	0	4	2	4	2	1	2	1	3	1	2	3	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr15:35084363C>T	uc001ziu.1	-	5	979	c.736G>A	c.(736-738)GAT>AAT	p.D246N	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	246					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding	p.D246N(1)		upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		ACTTGGCCATCAGGCAGTTCA	0.522													6	34					0	0	0	0	T	35084363	T	T	35084363	3	4	185	1	0	0	0	0	1	0	0	0	195	826	29	2	409	2	ACTC1	15	35084363	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08		35084363	67447029	76	34443											
CYP11A1	1583	broad.mit.edu	37	chr15	74630346	74630346	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttcctggttaaagggccaGaaggtgaaggagatgggctt	10	9	16	6	0	0	3	0	1	0	2	1	4	1	3	2	5	0	3	2	5	4	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr15:74630346G>A	uc002axt.2	-	9	1688	c.1533C>T	c.(1531-1533)TTC>TTT	p.F511F	CYP11A1_uc002axs.2_Silent_p.F353F|CYP11A1_uc010bjm.1_Silent_p.F353F|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Silent_p.F429F	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	511					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	TAAAGGGCCAGAAGGTGAAGG	0.552													13	33					0	0	0	0	A	74630346	A	A	74630346	2	1	185	1	0	0	0	0	0	0	0	1	4161	933	33	2		2	CYP11A1	15	74630346	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	39545983	74630346	27901046	77	34444											
MPG	4350	broad.mit.edu	37	chr16	129429	129429	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttttcccattacagttttgCcgacggatggggcaaaagaa	11	12	10	8	2	0	1	0	0	0	1	1	3	1	2	2	3	2	2	2	3	4	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:129429C>T	uc002cfn.2	+	3	363	c.45C>T	c.(43-45)TGC>TGT	p.C15C	MPG_uc002cfm.2_5'UTR|MPG_uc010bqp.2_5'UTR|MPG_uc002cfo.2_Silent_p.C10C	NM_002434	NP_002425	P29372	3MG_HUMAN	N-methylpurine-DNA glycosylase isoform a	15					depurination|DNA dealkylation involved in DNA repair	nucleoplasm	alkylbase DNA N-glycosylase activity|damaged DNA binding|identical protein binding			ovary(1)|skin(1)	2		all_cancers(16;9.01e-08)|all_epithelial(16;7.64e-07)|Hepatocellular(780;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				TACAGTTTTGCCGACGGATGG	0.547								BER_DNA_glycosylases					3	49					0	0	0	0	T	129429	T	T	129429	2	4	185	1	0	0	0	0	0	0	0	1	9777	747	26	4		4	MPG	16	129429	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08		129429	90225324	78	34445											
HN1L	90861	broad.mit.edu	37	chr16	1747824	1747824	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgttgcaggatcatgttttCttatgtgaaggagaagaacc	11	14	11	5	0	2	3	1	1	1	2	2	5	2	4	1	2	2	3	1	2	4	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:1747824C>G	uc002cmg.2	+	4	384	c.348C>G	c.(346-348)TTC>TTG	p.F116L	HN1L_uc010uvi.1_Missense_Mutation_p.F144L|HN1L_uc010brt.2_RNA|HN1L_uc010bru.2_Missense_Mutation_p.L69V|HN1L_uc010uvj.1_Missense_Mutation_p.L97V|HN1L_uc010uvk.1_Missense_Mutation_p.F103L	NM_144570	NP_653171	Q9H910	HN1L_HUMAN	hematological and neurological expressed 1-like	116						cytoplasm|nucleus		p.F116L(1)		upper_aerodigestive_tract(1)	1						ATCATGTTTTCTTATGTGAAG	0.393													28	80					0	0	0	0	G	1747824	G	G	1747824	3	3	185	1	0	0	0	0	1	0	0	0	7289	912	32	2	362	2	HN1L	16	1747824	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	1618395	1747824	88606929	79	34446											
ALG1	56052	broad.mit.edu	37	chr16	5123195	5123195	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggagtcaaagttgtacttCaggctatgtacttgctgtgg	9	13	12	7	1	2	0	2	0	0	0	2	1	2	1	0	3	3	5	0	3	4	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:5123195C>G	uc002cym.2	+	3	369	c.328C>G	c.(328-330)CAG>GAG	p.Q110E	ALG1_uc002cyj.2_5'UTR|ALG1_uc002cyn.2_Missense_Mutation_p.Q110E|ALG1_uc010bue.2_5'UTR|ALG1_uc010uxy.1_5'UTR	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	110	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity	p.Q110E(1)		upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)				AGTTGTACTTCAGGCTATGTA	0.517													9	38					0	0	0	0	G	5123195	G	G	5123195	3	3	185	1	0	0	0	0	1	0	0	0	510	827	29	2	338	2	ALG1	16	5123195	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	3375371	5123195	85231558	80	34447											
GRIN2A	2903	broad.mit.edu	37	chr16	10273897	10273897	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgcccccatgaatgcccaaGatggggacgaaggtgtggga	10	5	16	10	2	0	2	0	1	0	1	0	5	0	4	3	4	1	0	3	4	3	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:10273897G>A	uc002czo.3	-	2	920	c.372C>T	c.(370-372)ATC>ATT	p.I124I	GRIN2A_uc010uym.1_Silent_p.I124I|GRIN2A_uc002czr.3_Silent_p.I124I|GRIN2A_uc010buk.2_Silent_p.I124I	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	124	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAATGCCCAAGATGGGGACGA	0.612													12	27					0	0	0	0	A	10273897	A	A	10273897	2	1	185	1	0	0	0	0	0	0	0	1	6818	932	33	2		2	GRIN2A	16	10273897	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	5150702	10273897	80080856	81	34448											
LOC81691	81691	broad.mit.edu	37	chr16	20856517	20856517	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgaatcaacaaggctccCagggcttcgtgttgtacctc	9	10	9	13	1	1	1	1	1	0	0	4	1	2	1	3	2	2	4	3	2	4	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:20856517C>T	uc002dhv.2	+	18	2341	c.2078C>T	c.(2077-2079)CCA>CTA	p.P693L	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Missense_Mutation_p.P662L|LOC81691_uc002dhw.2_Missense_Mutation_p.P436L|LOC81691_uc002dhy.3_Missense_Mutation_p.P693L	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	693						nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						ACAAGGCTCCCAGGGCTTCGT	0.577													4	13					0	0	0	0	T	20856517	T	T	20856517	3	4	185	1	0	0	0	0	1	0	0	0	8940	594	21	4	2144	4	LOC81691	16	20856517	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	10582620	20856517	69498236	82	34449											
CDH16	1014	broad.mit.edu	37	chr16	66950205	66950205	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtactctgcctgctcctctCggtccagggccctggtcacc	3	10	11	17	1	3	0	1	0	2	0	6	0	5	0	5	4	3	2	5	4	1	1			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:66950205C>T	uc002eql.2	-	4	330	c.257G>A	c.(256-258)CGA>CAA	p.R86Q	CDH16_uc010cdy.2_Missense_Mutation_p.R86Q|CDH16_uc002eqm.2_Missense_Mutation_p.R86Q	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	86	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R86Q(1)		ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CTGCTCCTCTCGGTCCAGGGC	0.622													18	31					0	0	0	0	T	66950205	T	T	66950205	3	4	185	1	0	0	0	0	1	0	0	0	3116	884	31	1	2292	1	CDH16	16	66950205	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	46093688	66950205	23404548	83	34450											
CHST6	4166	broad.mit.edu	37	chr16	75513510	75513510	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggtccacacgtgccacgCgggctccattaggtagaaga	9	7	14	11	3	0	2	0	0	0	2	2	2	2	2	3	4	1	2	3	4	3	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:75513510C>T	uc002fef.2	-	3	397	c.217G>A	c.(217-219)GCG>ACG	p.A73T	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.A73T	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	73	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						ACGTGCCACGCGGGCTCCATT	0.662													12	19					0	0	0	0	T	75513510	T	T	75513510	3	4	185	1	0	0	0	0	1	0	0	0	3423	768	27	1	974	1	CHST6	16	75513510	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	8563305	75513510	14841243	84	34451											
TMEM93	83460	broad.mit.edu	37	chr17	3572587	3572587	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcctcggcctcaccggcctCtacggcttcatcttctacct	5	12	6	18	3	5	0	2	0	3	0	7	0	6	0	5	3	2	1	5	3	2	4	rs1148572		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:3572587C>G	uc002fwf.1	+	2	300	c.147C>G	c.(145-147)CTC>CTG	p.L49L	TAX1BP3_uc002fwc.2_5'Flank|P2RX5_uc002fwd.2_RNA|TAX1BP3_uc002fwe.1_5'Flank|TMEM93_uc002fwg.1_Silent_p.L49L|P2RX5_uc002fwh.1_3'UTR	NM_031298	NP_112588	Q9BV81	TMM93_HUMAN	transmembrane protein 93	49	Helical; (Potential).					integral to membrane					0						TCACCGGCCTCTACGGCTTCA	0.637													11	30					0	0	0	0	G	3572587	G	G	3572587	2	3	185	1	0	0	0	0	0	0	0	1	16288	900	32	2		2	TMEM93	17	3572587	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08		3572587	77622623	85	34452											
NLGN2	57555	broad.mit.edu	37	chr17	7319416	7319416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacctactggaccaacttcGccaagactgggtgagggcca	10	7	12	12	1	0	3	0	2	0	1	1	4	0	4	4	3	2	0	4	3	3	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:7319416G>A	uc002ggt.1	+	6	1697	c.1624G>A	c.(1624-1626)GCC>ACC	p.A542T		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	542	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				GACCAACTTCGCCAAGACTGG	0.517													12	25					0	0	0	0	A	7319416	A	A	7319416	3	1	185	1	0	0	0	0	1	0	0	0	10516	1087	38	1	1646	1	NLGN2	17	7319416	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	3746829	7319416	73875794	86	34453											
TP53	7157	broad.mit.edu	37	chr17	7576853	7576853	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtcccaagacttagtacCtgaagggtgaaatattctcc	12	10	10	9	0	1	3	0	2	1	1	3	4	2	3	3	2	1	1	3	2	6	4	rs11575996		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:7576853C>T	uc002gim.2	-	9	1187	c.993G>A	c.(991-993)CAG>CAA	p.Q331Q	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Silent_p.Q331Q|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Silent_p.Q199Q|TP53_uc010cng.1_Silent_p.Q199Q|TP53_uc002gii.1_Silent_p.Q199Q|TP53_uc010cnh.1_Silent_p.Q331Q|TP53_uc010cni.1_Silent_p.Q331Q|TP53_uc002gij.2_Silent_p.Q331Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	331	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(14)|p.0?(7)|p.Q331P(3)|p.Q331fs*6(1)|p.I332fs*49(1)|p.?(1)|p.Q331Q(1)|p.Q331R(1)|p.Q331H(1)|p.Q331fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACTTAGTACCTGAAGGGTGA	0.453		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	41					0	0	0	0	T	7576853	T	T	7576853	2	4	185	1	0	0	0	0	0	0	0	1	16448	695	24	4		4	TP53	17	7576853	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	257437	7576853	73618357	87	34454											
TP53	7157	broad.mit.edu	37	chr17	7577082	7577082	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttcttgcggagattctcttCctctgtgcgccggtctctcc	2	16	9	14	3	4	1	0	0	4	1	8	2	6	1	3	2	2	0	3	2	0	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:7577082C>T	uc002gim.2	-	8	1050	c.856G>A	c.(856-858)GAA>AAA	p.E286K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E286K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E154K|TP53_uc010cng.1_Missense_Mutation_p.E154K|TP53_uc002gii.1_Missense_Mutation_p.E154K|TP53_uc010cnh.1_Missense_Mutation_p.E286K|TP53_uc010cni.1_Missense_Mutation_p.E286K|TP53_uc002gij.2_Missense_Mutation_p.E286K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	286	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> G (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E286K(52)|p.E286*(14)|p.E286G(14)|p.0?(7)|p.E286V(6)|p.E286Q(5)|p.?(2)|p.E286D(2)|p.E286E(2)|p.R283fs*16(2)|p.E286fs*59(2)|p.E286fs*17(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.E286A(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.E285_L289delEEENL(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGATTCTCTTCCTCTGTGCGC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	20					0	0	0	0	T	7577082	T	T	7577082	3	4	185	1	0	0	0	0	1	0	0	0	16448	864	30	2	430	2	TP53	17	7577082	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	229	7577082	73618128	88	34455											
SEZ6	124925	broad.mit.edu	37	chr17	27287979	27287979	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tggtggcattgcggatcactCcgccgcaagcagctgttaag	8	9	13	11	3	1	0	1	0	0	0	2	1	2	1	2	3	3	5	2	3	2	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:27287979C>G	uc002hdp.2	-	6	1447	c.1253G>C	c.(1252-1254)GGA>GCA	p.G418A	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.G418A|SEZ6_uc002hdq.1_Missense_Mutation_p.G293A	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	418	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			GCGGATCACTCCGCCGCAAGC	0.607													23	113					0	0	0	0	G	27287979	G	G	27287979	3	3	185	1	0	0	0	0	1	0	0	0	14207	855	30	2	1792	2	SEZ6	17	27287979	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	19710897	27287979	53907231	89	34456											
GAS2L2	246176	broad.mit.edu	37	chr17	34079822	34079822	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccggatactgcacacaggCggccctagggtcctgggctt	6	7	15	13	2	0	0	0	0	0	0	1	1	1	1	3	6	2	2	3	6	2	3	rs147495893	by1000genomes	TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:34079822C>A	uc002hjv.1	-	1	76	c.48G>T	c.(46-48)CCG>CCT	p.P16P		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	16					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCACACAGGCGGCCCTAGGG	0.657													16	51					9.16793e-09	1.022e-08	1	0	A	34079822	A	A	34079822	2	1	185	1	0	0	0	0	0	0	0	1	6282	755	27	3		3	GAS2L2	17	34079822	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08	6791843	34079822	47115388	90	34457											
G6PC3	92579	broad.mit.edu	37	chr17	42148497	42148497	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcctcccgccgtgtgggcaTcgcggtgctctggatcagcc	3	8	14	16	5	2	0	1	0	1	0	4	1	3	1	4	3	2	2	4	3	0	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:42148497T>C	uc002iex.2	+	1	380	c.164T>C	c.(163-165)ATC>ACC	p.I55T	G6PC3_uc002iey.2_5'UTR|G6PC3_uc010czo.2_5'UTR|G6PC3_uc002iez.2_5'UTR|G6PC3_uc002ifa.1_Missense_Mutation_p.I55T	NM_138387	NP_612396	Q9BUM1	G6PC3_HUMAN	glucose-6-phosphatase catalytic subunit 3	55	Helical; (Potential).				gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			skin(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CGTGTGGGCATCGCGGTGCTC	0.612													10	26					0	0	0	0	C	42148497	C	C	42148497	3	2	185	1	0	0	0	0	1	0	0	0	6179	1435	50	5	166	5	G6PC3	17	42148497	Missense_Mutation	SNP	T	TCGA-CV-5977-01A-11D-1683-08	8068675	42148497	39046713	91	34458											
SLC25A39	51629	broad.mit.edu	37	chr17	42397759	42397759	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgctcccagagcgacctggcGttgggtctttaccacgtcaa	7	9	11	14	4	2	1	1	0	1	1	3	2	3	1	3	2	2	2	3	2	2	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:42397759G>A	uc002ign.2	-	10	1001	c.847C>T	c.(847-849)CGC>TGC	p.R283C	SLC25A39_uc002igm.2_Missense_Mutation_p.R275C|SLC25A39_uc002igo.2_Missense_Mutation_p.R275C|SLC25A39_uc010wiw.1_Missense_Mutation_p.R260C|SLC25A39_uc010czu.2_Missense_Mutation_p.R151C	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	283	Solcar 3.				heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane		p.R275C(1)		upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GCGACCTGGCGTTGGGTCTTT	0.652													29	21					0	0	0	0	A	42397759	A	A	42397759	3	1	185	1	0	0	0	0	1	0	0	0	14567	1145	40	1	244	1	SLC25A39	17	42397759	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	249262	42397759	38797451	92	34459											
BAHCC1	57597	broad.mit.edu	37	chr17	79409052	79409052	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtgggcaaagagctgggcaGagagaaggcgggcaaggccg	11	2	20	8	3	0	3	0	0	0	3	0	4	0	3	1	5	1	4	1	5	3	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:79409052G>A	uc002kaf.2	+	3	677	c.677G>A	c.(676-678)AGA>AAA	p.R226K	BAHCC1_uc002kae.2_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	226							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GAGCTGGGCAGAGAGAAGGCG	0.692													6	22					0	0	0	0	A	79409052	A	A	79409052	3	1	185	1	0	0	0	0	1	0	0	0	1298	942	33	2	526	2	BAHCC1	17	79409052	Missense_Mutation	SNP	G	TCGA-CV-5977-01A-11D-1683-08	37011293	79409052	1786158	93	34460											
LAMA1	284217	broad.mit.edu	37	chr18	7044739	7044739	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttcacatgtattgccggAggacacggttcccggcctcc	7	9	10	15	3	1	0	1	0	0	0	3	2	3	2	5	4	1	2	5	4	1	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr18:7044739A>G	uc002knm.2	-	7	1052	c.958T>C	c.(958-960)TCC>CCC	p.S320P	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	320	Laminin EGF-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTATTGCCGGAGGACACGGTT	0.468													22	120					0	0	0	0	G	7044739	G	G	7044739	3	3	185	1	0	0	0	0	1	0	0	0	8645	304	11	5	8497	5	LAMA1	18	7044739	Missense_Mutation	SNP	A	TCGA-CV-5977-01A-11D-1683-08		7044739	71032509	94	34461											
C19orf21	126353	broad.mit.edu	37	chr19	758639	758639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcaagaggtggcagaggagCggagaaatgctctcttccca	12	6	14	9	1	1	3	0	0	1	3	3	5	2	4	1	4	3	3	1	4	2	1	rs138693251		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:758639C>T	uc002lpo.2	+	2	1776	c.1693C>T	c.(1693-1695)CGG>TGG	p.R565W		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	565	Potential.							p.R565W(1)		upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCAGAGGAGCGGAGAAATGC	0.607													25	42					0	0	0	0	T	758639	T	T	758639	3	4	185	1	0	0	0	0	1	0	0	0	1922	759	27	1	1695	1	C19orf21	19	758639	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08		758639	58370344	95	34462											
C19orf29	58509	broad.mit.edu	37	chr19	3613305	3613305	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgtccacctcggcctccgCggggccgccctccgaggagg	3	4	15	19	6	0	0	0	0	0	0	4	2	3	1	8	5	0	0	8	5	0	0			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:3613305C>T	uc002lyh.2	-	9	1590	c.1537G>A	c.(1537-1539)GCG>ACG	p.A513T	C19orf29_uc010xho.1_5'UTR|C19orf29_uc010dtn.2_Missense_Mutation_p.A361T|C19orf29_uc002lyi.3_Missense_Mutation_p.A513T|C19orf29_uc010dto.2_RNA|C19orf29_uc010xhp.1_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	513						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGCCTCCGCGGGGCCGCCC	0.781													8	9					0	0	0	0	T	3613305	T	T	3613305	3	4	185	1	0	0	0	0	1	0	0	0	1927	768	27	1	747	1	C19orf29	19	3613305	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	2854666	3613305	55515678	96	34463											
DPP9	91039	broad.mit.edu	37	chr19	4679886	4679886	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgctcggatcagttgggaGacgaggaagtttgtgtggaa	9	10	16	6	2	1	1	1	0	0	1	2	6	1	4	1	4	1	3	1	4	2	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:4679886G>A	uc002mba.2	-	21	2805	c.2547C>T	c.(2545-2547)GTC>GTT	p.V849V		NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	820					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		TCAGTTGGGAGACGAGGAAGT	0.602													3	11					0	0	0	0	A	4679886	A	A	4679886	2	1	185	1	0	0	0	0	0	0	0	1	4755	929	33	2		2	DPP9	19	4679886	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	1066581	4679886	54449097	97	34464											
ZNRF4	148066	broad.mit.edu	37	chr19	5455843	5455843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcgagctcggtggactttgCggatctgccggcgctgttcg	3	11	15	12	6	1	0	0	0	1	0	4	3	1	2	1	4	3	3	1	4	0	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:5455843C>T	uc002mca.3	+	1	418	c.341C>T	c.(340-342)GCG>GTG	p.A114V		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	114	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GTGGACTTTGCGGATCTGCCG	0.667													4	109					0	0	0	0	T	5455843	T	T	5455843	3	4	185	1	0	0	0	0	1	0	0	0	18281	768	27	1	343	1	ZNRF4	19	5455843	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	775957	5455843	53673140	98	34465											
ACTL9	284382	broad.mit.edu	37	chr19	8807822	8807822	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtagcatttgcggtacacGatatagggaccctgttcctc	9	11	10	11	2	0	0	0	0	0	0	2	2	1	1	2	2	3	4	2	2	4	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:8807822G>A	uc002mkl.2	-	1	1351	c.1230C>T	c.(1228-1230)ATC>ATT	p.I410I		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	410						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						TGCGGTACACGATATAGGGAC	0.632													21	36					0	0	0	0	A	8807822	A	A	8807822	2	1	185	1	0	0	0	0	0	0	0	1	203	1048	37	1		1	ACTL9	19	8807822	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	3351979	8807822	50321161	99	34466											
OR7D2	162998	broad.mit.edu	37	chr19	9296557	9296557	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatttgggctgttcctgtccAtgtacctggtgacggtgctg	4	15	13	9	1	0	1	0	1	0	0	2	1	2	1	3	3	2	4	3	3	2	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:9296557A>G	uc002mkz.1	+	1	288	c.100A>G	c.(100-102)ATG>GTG	p.M34V		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	34	Helical; Name=1; (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M34V(1)		ovary(2)|upper_aerodigestive_tract(1)	3						GTTCCTGTCCATGTACCTGGT	0.512													3	27					0	0	0	0	G	9296557	G	G	9296557	3	3	185	1	0	0	0	0	1	0	0	0	11273	217	8	5	102	5	OR7D2	19	9296557	Missense_Mutation	SNP	A	TCGA-CV-5977-01A-11D-1683-08	488735	9296557	49832426	100	34467											
ZNF653	115950	broad.mit.edu	37	chr19	11598501	11598501	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctgggttggagcacagcggGgtaccctgctcggccaggct	5	7	17	12	2	0	0	0	0	0	0	1	1	0	1	2	6	4	6	2	6	1	2			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:11598501G>T	uc002mrz.1	-	4	830	c.777C>A	c.(775-777)ACC>ACA	p.T259T		NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGCACAGCGGGGTACCCTGCT	0.682													26	47					8.24728e-16	9.42547e-16	1	0	T	11598501	T	T	11598501	2	4	185	1	0	0	0	0	0	0	0	1	18133	1219	43	4		4	ZNF653	19	11598501	Silent	SNP	G	TCGA-CV-5977-01A-11D-1683-08	2301944	11598501	47530482	101	34468											
ZNF708	7562	broad.mit.edu	37	chr19	21493405	21493405	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccagagagaattctatggCcacatccataaatgtcaatg	14	10	7	10	0	2	2	1	0	1	2	4	3	4	2	3	1	0	0	3	1	5	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:21493405C>A	uc002npq.1	-	2	226	c.28G>T	c.(28-30)GCC>TCC	p.A10S	ZNF708_uc002npr.1_Intron|ZNF708_uc010ecs.1_Intron	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						AATTCTATGGCCACATCCATA	0.388													28	45					1.50538e-07	1.63785e-07	1	0	A	21493405	A	A	21493405	3	1	185	1	0	0	0	0	1	0	0	0	18179	739	26	4	1675	4	ZNF708	19	21493405	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	9894904	21493405	37635578	102	34469											
ZNF534	147658	broad.mit.edu	37	chr19	52941603	52941603	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcatactggagagaagcCttacaaatgtagtgaatgtg	15	11	10	5	0	1	2	1	1	0	1	1	4	1	3	1	1	3	1	1	1	7	4			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:52941603C>A	uc002pzk.2	+	4	990	c.929C>A	c.(928-930)CCT>CAT	p.P310H	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.P297H	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAGAGAAGCCTTACAAATGT	0.393													5	28					0.000602214	0.000634893	1	0	A	52941603	A	A	52941603	3	1	185	1	0	0	0	0	1	0	0	0	18040	681	24	4	943	4	ZNF534	19	52941603	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08	31448198	52941603	6187380	103	34470											
SCRT2	85508	broad.mit.edu	37	chr20	644433	644433	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttgtcgcactggcggcagCggtagtgcttgaaggccgag	6	9	16	10	4	1	1	0	1	1	0	2	2	1	1	1	4	2	4	1	4	2	3			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr20:644433C>T	uc002wec.2	-	2	1384	c.806G>A	c.(805-807)CGC>CAC	p.R269H	SRXN1_uc002web.2_Intron	NM_033129	NP_149120	Q9NQ03	SCRT2_HUMAN	scratch 2 protein	269	C2H2-type 5; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTGGCGGCAGCGGTAGTGCTT	0.701													7	6					0	0	0	0	T	644433	T	T	644433	3	4	185	1	0	0	0	0	1	0	0	0	14007	768	27	1	121	1	SCRT2	20	644433	Missense_Mutation	SNP	C	TCGA-CV-5977-01A-11D-1683-08		644433	62381087	104	34471											
DSCAM	1826	broad.mit.edu	37	chr21	41719759	41719759	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggttgaggatttcaccatTgcggtaccaggagagttcct	9	11	13	8	1	1	2	1	1	0	1	2	4	2	3	3	4	2	3	3	4	1	5			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr21:41719759T>C	uc002yyq.1	-	6	1500	c.1048A>G	c.(1048-1050)AAT>GAT	p.N350D	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	350	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ATTTCACCATTGCGGTACCAG	0.502													5	129					0	0	0	0	C	41719759	C	C	41719759	3	2	185	1	0	0	0	0	1	0	0	0	4790	1812	63	5	5102	5	DSCAM	21	41719759	Missense_Mutation	SNP	T	TCGA-CV-5977-01A-11D-1683-08		41719759	6410136	105	34472											
EFCAB6	64800	broad.mit.edu	37	chr22	44004470	44004470	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgccctcattatcggttTctagaaaattctacaacatc	12	14	4	11	1	3	1	1	0	2	1	5	1	3	1	1	1	3	1	1	1	6	6			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr22:44004470T>C	uc003bdy.1	-	22	2788	c.2573A>G	c.(2572-2574)GAA>GGA	p.E858G	EFCAB6_uc003bdz.1_Missense_Mutation_p.E706G|EFCAB6_uc010gzi.1_Missense_Mutation_p.E706G|EFCAB6_uc010gzj.1_Intron	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	858	EF-hand 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding	p.E858G(1)		ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				ATTATCGGTTTCTAGAAAATT	0.403													12	34					0	0	0	0	C	44004470	C	C	44004470	3	2	185	1	0	0	0	0	1	0	0	0	4961	1783	62	5	1976	5	EFCAB6	22	44004470	Missense_Mutation	SNP	T	TCGA-CV-5977-01A-11D-1683-08		44004470	7300096	106	34473											
XPNPEP2	7512	broad.mit.edu	37	chrX	128887212	128887212	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaaggagcaggccctcctCaaggccagccacgtaagtcc	11	4	11	15	1	1	0	1	0	0	0	3	1	3	1	5	3	3	3	5	3	3	1			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chrX:128887212C>G	uc004eut.1	+	11	1339	c.1095C>G	c.(1093-1095)CTC>CTG	p.L365L		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	365					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						AGGCCCTCCTCAAGGCCAGCC	0.537													33	51					0	0	0	0	G	128887212	G	G	128887212	2	3	185	1	0	0	0	0	0	0	0	1	17511	813	29	2		2	XPNPEP2	23	128887212	Silent	SNP	C	TCGA-CV-5977-01A-11D-1683-08		128887212	26383348	107	34474											
DVL1	1855	broad.mit.edu	37	chr1	1273764	1273764	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgtacttccgggcctcccgCcgctccttgaagccctccac	4	8	9	20	4	0	1	0	1	0	0	4	1	4	1	7	1	2	2	7	1	2	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:1273764C>A	uc001aer.3	-	13	1364	c.1317G>T	c.(1315-1317)CGG>CGT	p.R439R	DVL1_uc002quu.2_Silent_p.R181R|DVL1_uc009vka.2_Silent_p.R122R|DVL1_uc001aeu.1_Silent_p.R198R	NM_004421	NP_004412	O14640	DVL1_HUMAN	dishevelled 1	464	DEP.				canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGGCCTCCCGCCGCTCCTTGA	0.657													6	10					0.00198382	0.00206933	1	0	A	1273764	A	A	1273764	2	1	186	1	0	0	0	0	0	0	0	1	4857	726	26	4		4	DVL1	1	1273764	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08		1273764	247976857	1	34475											
RAD54L	8438	broad.mit.edu	37	chr1	46726604	46726604	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctggtgaagaactggtacaAtgaggttgggaaatggctcg	11	9	15	6	1	0	3	0	2	0	1	1	4	0	4	1	5	2	3	1	5	5	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:46726604A>G	uc009vye.2	+	8	797	c.683A>G	c.(682-684)AAT>AGT	p.N228S	RAD54L_uc001cpl.2_Missense_Mutation_p.N228S|RAD54L_uc001cpm.1_Missense_Mutation_p.N48S	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	228	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		AACTGGTACAATGAGGTTGGG	0.512								Direct_reversal_of_damage|Homologous_recombination					5	43					0	0	0	0	G	46726604	G	G	46726604	3	3	186	1	0	0	0	0	1	0	0	0	13058	101	4	5	709	5	RAD54L	1	46726604	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08	45452840	46726604	202524017	2	34476											
RPE65	6121	broad.mit.edu	37	chr1	68896799	68896799	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aacaaagatgggttctgatgGgtatgaatcaggctcttgcc	11	11	12	7	0	3	3	1	2	2	1	3	3	3	3	1	3	2	3	1	3	4	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:68896799G>A	uc001dei.1	-	13	1453	c.1399C>T	c.(1399-1401)CCA>TCA	p.P467S		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	467					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						GGTTCTGATGGGTATGAATCA	0.393													19	36					0	0	0	0	A	68896799	A	A	68896799	3	1	186	1	0	0	0	0	1	0	0	0	13610	1232	43	4	210	4	RPE65	1	68896799	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	22170195	68896799	180353822	3	34477											
FAM63A	55793	broad.mit.edu	37	chr1	150974779	150974779	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tctggctcaggctgtcgggtCctgggggactgaggaagctc	5	9	17	10	1	2	1	1	1	1	0	5	3	3	3	1	6	1	3	1	6	1	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:150974779C>G	uc001ewf.2	-	3	1999	c.315G>C	c.(313-315)AGG>AGC	p.R105S	FAM63A_uc001ewc.2_5'UTR|FAM63A_uc010pcm.1_Missense_Mutation_p.R10S|FAM63A_uc001ewd.2_5'UTR|FAM63A_uc001ewe.2_Intron|FAM63A_uc010pcn.1_Missense_Mutation_p.R153S|FAM63A_uc001ewg.2_Missense_Mutation_p.R105S	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	105							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCTGTCGGGTCCTGGGGGACT	0.577													8	85					0	0	0	0	G	150974779	G	G	150974779	3	3	186	1	0	0	0	0	1	0	0	0	5628	854	30	2	1130	2	FAM63A	1	150974779	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	82077980	150974779	98275842	4	34478											
DENND4B	9909	broad.mit.edu	37	chr1	153910068	153910068	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agactcaaacaactcagcccGtagctctgggaatccatcat	13	8	7	13	1	4	1	3	0	1	1	5	2	5	2	2	1	4	2	2	1	4	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:153910068G>A	uc001fdd.1	-	15	2529	c.2128C>T	c.(2128-2130)CGG>TGG	p.R710W		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	710										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AACTCAGCCCGTAGCTCTGGG	0.612													12	38					0	0	0	0	A	153910068	A	A	153910068	3	1	186	1	0	0	0	0	1	0	0	0	4456	1144	40	1	2418	1	DENND4B	1	153910068	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	2935289	153910068	95340553	5	34479											
TDRD10	126668	broad.mit.edu	37	chr1	154480950	154480950	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggcaatcttccactggataTttctaaggtatttattcttc	9	18	6	8	0	3	0	0	0	3	0	5	1	4	1	1	3	0	2	1	3	5	9			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:154480950T>C	uc009wow.2	+	4	972	c.134T>C	c.(133-135)ATT>ACT	p.I45T	TDRD10_uc001ffd.2_Missense_Mutation_p.I45T	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	45	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCACTGGATATTTCTAAGGTA	0.378													44	81					0	0	0	0	C	154480950	C	C	154480950	3	2	186	1	0	0	0	0	1	0	0	0	15797	1493	52	5	144	5	TDRD10	1	154480950	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	570882	154480950	94769671	6	34480											
SLC25A44	9673	broad.mit.edu	37	chr1	156161890	156161890	+	5'Flank	DEL	C	-	-																															aggctccaaagaggagttttCcagtctctttcctgggttta																										TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:156161890delC	uc001fnp.2	+						SLC25A44_uc010phc.1_5'Flank|SLC25A44_uc009wrr.2_5'Flank|SLC25A44_uc010phd.1_5'Flank|SLC25A44_uc010phe.1_5'Flank	NM_014655	NP_055470	Q96H78	S2544_HUMAN	solute carrier family 25, member 44						transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	Hepatocellular(266;0.158)					GAGGAGTTTTCCAGTCTCTTT	0.209													---	---	---								-	156161890	-	-	156161890	6	5	186	0	1	1	0	1	0	0	0	0	14573	870	30	0		0	SLC25A44	1	156161890	5'Flank	DEL	C	TCGA-CV-5978-01A-11D-1683-08	1680940	156161890	93088731	7	34481											
DARC	2532	broad.mit.edu	37	chr1	159175705	159175705	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgggccacagactgggtgCaggccaggtcccaggcctca	7	5	14	15	0	1	1	1	0	0	1	2	1	2	1	5	5	1	1	5	5	0	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:159175705C>G	uc001fto.2	+	2	716	c.476C>G	c.(475-477)GCA>GGA	p.A159G	DARC_uc001ftp.3_Missense_Mutation_p.A161G	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	159	Cytoplasmic (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					AGACTGGGTGCAGGCCAGGTC	0.632													3	28					0	0	0	0	G	159175705	G	G	159175705	3	3	186	1	0	0	0	0	1	0	0	0	4257	710	25	4	509	4	DARC	1	159175705	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	3013815	159175705	90074916	8	34482											
ATP1A4	480	broad.mit.edu	37	chr1	160124906	160124906	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgttaccccaccccccacCactccagaatgggtcaaatt	11	8	5	17	0	1	1	1	0	0	1	2	1	2	1	7	1	1	1	7	1	3	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:160124906C>A	uc001fve.3	+	3	758	c.279C>A	c.(277-279)ACC>ACA	p.T93T	ATP1A4_uc001fvf.3_RNA	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	93	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CACCCCCCACCACTCCAGAAT	0.527													16	68					1.33834e-09	1.65244e-09	1	0	A	160124906	A	A	160124906	2	1	186	1	0	0	0	0	0	0	0	1	1133	581	21	4		4	ATP1A4	1	160124906	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	949201	160124906	89125715	9	34483											
CD84	8832	broad.mit.edu	37	chr1	160535331	160535331	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggacctaaggcatgtatcCgttcataataatttctgtgg	10	14	9	8	2	2	0	1	0	1	0	4	1	3	1	2	3	0	3	2	3	4	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:160535331C>T	uc001fwh.3	-	2	275	c.251G>A	c.(250-252)CGG>CAG	p.R84Q	CD84_uc001fwf.3_Missense_Mutation_p.R84Q|CD84_uc001fwg.3_Missense_Mutation_p.R84Q|CD84_uc009wtn.2_Missense_Mutation_p.R84Q|CD84_uc001fwi.3_Intron|CD84_uc001fwj.2_Missense_Mutation_p.R84Q|CD84_uc001fwk.2_Missense_Mutation_p.R84Q	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	84	Extracellular (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity	p.R84W(1)		ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GGCATGTATCCGTTCATAATA	0.438													23	146					0	0	0	0	T	160535331	T	T	160535331	3	4	186	1	0	0	0	0	1	0	0	0	3057	652	23	1	814	1	CD84	1	160535331	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	410425	160535331	88715290	10	34484											
DNM3	26052	broad.mit.edu	37	chr1	171956944	171956944	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacgagtctattccccacaCggtaagtaaaataataaaat	17	11	5	8	2	1	0	0	0	1	0	2	1	2	0	2	1	1	2	2	1	8	7			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:171956944C>A	uc001gie.2	+	3	560	c.384C>A	c.(382-384)CAC>CAA	p.H128Q	DNM3_uc001gid.3_Missense_Mutation_p.H128Q|DNM3_uc009wwb.2_Missense_Mutation_p.H128Q|DNM3_uc001gif.2_Missense_Mutation_p.H128Q	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	128					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						ATTCCCCACACGGTAAGTAAA	0.348													10	88					3.86212e-05	4.28731e-05	1	0	A	171956944	A	A	171956944	3	1	186	1	0	0	0	0	1	0	0	0	4695	550	19	3	394	3	DNM3	1	171956944	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	11421613	171956944	77293677	11	34485											
PAPPA2	60676	broad.mit.edu	37	chr1	176708895	176708895	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccgtggaagcaaccactctcTtggtgagtctgacaaatatc	11	10	9	11	1	2	2	0	2	2	0	4	3	2	3	2	2	2	1	2	2	4	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:176708895T>C	uc001gkz.2	+	13	5096	c.3932T>C	c.(3931-3933)CTT>CCT	p.L1311P	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1311					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AACCACTCTCTTGGTGAGTCT	0.478													4	37					0	0	0	0	C	176708895	C	C	176708895	3	2	186	1	0	0	0	0	1	0	0	0	11487	1609	56	5	4031	5	PAPPA2	1	176708895	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	4751951	176708895	72541726	12	34486											
PDC	5132	broad.mit.edu	37	chr1	186413572	186413572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcctgcatacactgtctacGgtatttacgaaggcagtttt	10	14	8	9	2	1	0	0	0	1	0	2	1	2	0	1	2	4	4	1	2	5	7			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:186413572G>A	uc001gsa.2	-	4	353	c.280C>T	c.(280-282)CGT>TGT	p.R94C	PDC_uc001grz.2_Missense_Mutation_p.R42C	NM_002597	NP_002588	P20941	PHOS_HUMAN	phosducin isoform a	94					G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity			skin(1)	1		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)		CACTGTCTACGGTATTTACGA	0.368													4	110					0	0	0	0	A	186413572	A	A	186413572	3	1	186	1	0	0	0	0	1	0	0	0	11668	1116	39	1	464	1	PDC	1	186413572	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	9704677	186413572	62837049	13	34487											
FAM5C	339479	broad.mit.edu	37	chr1	190067913	190067913	+	Frame_Shift_Del	DEL	G	-	-																															atgtcattgctgataaaaatGgcatggacttctattcgtct																										TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:190067913delG	uc001gse.1	-	8	1768	c.1536delC	c.(1534-1536)GCCfs	p.A512fs	FAM5C_uc010pot.1_Frame_Shift_Del_p.A410fs	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	512						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TGATAAAAATGGCATGGACTT	0.463													---	---	---								-	190067913	-	-	190067913	7	5	186	1	0	1	0	1	0	0	0	0	5626	1335	47	0	768	0	FAM5C	1	190067913	Frame_Shift_Del	DEL	G	TCGA-CV-5978-01A-11D-1683-08	3654341	190067913	59182708	14	34488											
RGS18	64407	broad.mit.edu	37	chr1	192127873	192127873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaagaagaaacaagcaaaGaagccaaaatcaggtaaaat	25	3	8	5	0	1	3	1	0	0	3	1	4	1	3	1	1	3	2	1	1	11	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:192127873G>A	uc001gsg.2	+	1	282	c.106G>A	c.(106-108)GAA>AAA	p.E36K		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	regulator of G-protein signalling 18	36					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3						AACAAGCAAAGAAGCCAAAAT	0.274													12	25					0	0	0	0	A	192127873	A	A	192127873	3	1	186	1	0	0	0	0	1	0	0	0	13365	943	33	2	108	2	RGS18	1	192127873	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	2059960	192127873	57122748	15	34489											
SRGAP2	23380	broad.mit.edu	37	chr1	206631989	206631989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaaaggaagcgtccagaatCtgggagcatccggaaaactt	14	6	12	9	2	1	1	0	0	1	1	3	4	3	4	2	3	3	2	2	3	5	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:206631989C>T	uc001hdy.2	+	19	2600	c.2267C>T	c.(2266-2268)TCT>TTT	p.S756F	SRGAP2_uc010pru.1_Missense_Mutation_p.S679F	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	843	Ser-rich.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					CGTCCAGAATCTGGGAGCATC	0.582													6	4					0	0	0	0	T	206631989	T	T	206631989	3	4	186	1	0	0	0	0	1	0	0	0	15212	913	32	2	2346	2	SRGAP2	1	206631989	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	14504116	206631989	42618632	16	34490											
CR2	1380	broad.mit.edu	37	chr1	207646235	207646235	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccctgggccagaaagaggAgtggaattcagcctcattgg	12	7	13	9	0	2	2	2	0	0	2	2	4	2	4	3	4	2	0	3	4	3	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:207646235A>G	uc001hfw.2	+	10	1783	c.1689A>G	c.(1687-1689)GGA>GGG	p.G563G	CR2_uc001hfv.2_Silent_p.G563G|CR2_uc009xch.2_Silent_p.G563G|CR2_uc009xci.1_Silent_p.G48G	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	563	Sushi 9.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						CAGAAAGAGGAGTGGAATTCA	0.507													7	52					0	0	0	0	G	207646235	G	G	207646235	2	3	186	1	0	0	0	0	0	0	0	1	3857	291	11	5		5	CR2	1	207646235	Silent	SNP	A	TCGA-CV-5978-01A-11D-1683-08	1014246	207646235	41604386	17	34491											
CAPN9	10753	broad.mit.edu	37	chr1	230903376	230903376	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtggcagagaccttccaaaCtaaagaggcccccgagaact	13	6	10	12	1	0	3	0	0	0	3	1	5	1	3	4	2	2	1	4	2	4	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:230903376C>A	uc001htz.1	+	5	739	c.626C>A	c.(625-627)ACT>AAT	p.T209N	CAPN9_uc009xfg.1_Missense_Mutation_p.T146N|CAPN9_uc001hua.1_Missense_Mutation_p.T209N	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	209	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				ACCTTCCAAACTAAAGAGGCC	0.542													32	97					1.62565e-12	2.14976e-12	1	0	A	230903376	A	A	230903376	3	1	186	1	0	0	0	0	1	0	0	0	2644	565	20	4	644	4	CAPN9	1	230903376	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	23257141	230903376	18347245	18	34492											
OR2W3	343171	broad.mit.edu	37	chr1	248058896	248058896	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcagcagtagagatggatgGaaccaatggcagcacccaaa	16	4	12	9	0	0	1	0	0	0	1	0	4	0	3	2	3	4	5	2	3	4	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr1:248058896G>A	uc001idp.1	+	3	277	c.8G>A	c.(7-9)GGA>GAA	p.G3E	OR2W3_uc010pzb.1_Missense_Mutation_p.G3E	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAGATGGATGGAACCAATGGC	0.348													6	24					0	0	0	0	A	248058896	A	A	248058896	3	1	186	1	0	0	0	0	1	0	0	0	11087	1174	41	2	10	2	OR2W3	1	248058896	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	17155520	248058896	1191725	19	34493											
TACR1	6869	broad.mit.edu	37	chr2	75425690	75425690	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctatcaaaggccacagccGtcatggagtagatactggcg	12	7	11	11	2	2	1	2	0	0	1	2	2	2	2	3	3	2	1	3	3	4	3	rs138993766		TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr2:75425690G>A	uc002sng.2	-	1	956	c.371C>T	c.(370-372)ACG>ATG	p.T124M	TACR1_uc002snh.2_Missense_Mutation_p.T124M	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	124	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	GGCCACAGCCGTCATGGAGTA	0.512													9	51					0	0	0	0	A	75425690	A	A	75425690	3	1	186	1	0	0	0	0	1	0	0	0	15571	1145	40	1	876	1	TACR1	2	75425690	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08		75425690	167773683	20	34494											
TFCP2L1	29842	broad.mit.edu	37	chr2	122038776	122038776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaacacatattgcaggggtGgcaggcgggcctcgttctcg	8	8	14	11	3	1	0	0	0	1	0	3	0	1	0	1	5	2	3	1	5	2	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr2:122038776G>A	uc002tmx.2	-	2	227	c.134C>T	c.(133-135)CCA>CTA	p.P45L	TFCP2L1_uc010flr.2_Missense_Mutation_p.P45L	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	45	Mediate transcriptional repression.				female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					TTGCAGGGGTGGCAGGCGGGC	0.617													40	134					0	0	0	0	A	122038776	A	A	122038776	3	1	186	1	0	0	0	0	1	0	0	0	15862	1348	47	4	1361	4	TFCP2L1	2	122038776	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	46613086	122038776	121160597	21	34495											
GYPC	2995	broad.mit.edu	37	chr2	127447862	127447862	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatggcctctgcctccacCacaatgcatactaccaccat	10	8	7	16	0	1	0	0	0	1	0	2	1	2	1	6	2	4	1	6	2	3	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr2:127447862C>A	uc002tnq.2	+	2	237	c.81C>A	c.(79-81)ACC>ACA	p.T27T	GYPC_uc002tnr.2_Intron|GYPC_uc010flv.2_RNA	NM_002101	NP_002092	P04921	GLPC_HUMAN	glycophorin C isoform 1	27	Extracellular.					cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)	1	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		CTGCCTCCACCACAATGCATA	0.532													8	38					0.000442599	0.000478165	1	0	A	127447862	A	A	127447862	2	1	186	1	0	0	0	0	0	0	0	1	6949	581	21	4		4	GYPC	2	127447862	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	5409086	127447862	115751511	22	34496											
GYPC	2995	broad.mit.edu	37	chr2	127453707	127453707	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgatagcagcagaaaggagTactttatttgagggacaaca	15	9	12	5	0	0	3	0	2	0	1	0	5	0	5	0	2	4	3	0	2	5	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr2:127453707T>G	uc002tnq.2	+	4	532	c.376T>G	c.(376-378)TAC>GAC	p.Y126D	GYPC_uc002tnr.2_Missense_Mutation_p.Y107D|GYPC_uc010flv.2_RNA	NM_002101	NP_002092	P04921	GLPC_HUMAN	glycophorin C isoform 1	126	Cytoplasmic.					cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)	1	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		CAGAAAGGAGTACTTTATTTG	0.552													8	19					0	0	0	0	G	127453707	G	G	127453707	3	3	186	1	0	0	0	0	1	0	0	0	6949	1638	57	5	390	5	GYPC	2	127453707	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	5845	127453707	115745666	23	34497											
IWS1	55677	broad.mit.edu	37	chr2	128262822	128262822	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttctgaatcactgacctgAggtttaggaagctcctcact	9	13	8	11	0	3	3	2	3	1	0	4	4	4	4	2	2	1	2	2	2	3	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr2:128262822A>G	uc002ton.2	-	3	960	c.657T>C	c.(655-657)CCT>CCC	p.P219P	IWS1_uc010yzl.1_RNA|IWS1_uc010fma.2_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	219	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		CACTGACCTGAGGTTTAGGAA	0.512													32	195					0	0	0	0	G	128262822	G	G	128262822	2	3	186	1	0	0	0	0	0	0	0	1	7970	291	11	5		5	IWS1	2	128262822	Silent	SNP	A	TCGA-CV-5978-01A-11D-1683-08	809115	128262822	114936551	24	34498											
FAM123C	205147	broad.mit.edu	37	chr2	131521962	131521962	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggcctctgtggaggacCagcccttgcagctcagcaca	7	7	12	15	0	2	0	1	0	1	0	2	2	2	2	4	3	4	3	4	3	0	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr2:131521962C>A	uc002trw.2	+	2	2507	c.2317C>A	c.(2317-2319)CAG>AAG	p.Q773K	FAM123C_uc010fmv.2_Missense_Mutation_p.Q773K|FAM123C_uc010fms.1_Missense_Mutation_p.Q773K|FAM123C_uc010fmt.1_Missense_Mutation_p.Q773K|FAM123C_uc010fmu.1_Missense_Mutation_p.Q773K	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	773										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		TGTGGAGGACCAGCCCTTGCA	0.672													5	26					1.23904e-05	1.39464e-05	1	0	A	131521962	A	A	131521962	3	1	186	1	0	0	0	0	1	0	0	0	5452	595	21	4	2319	4	FAM123C	2	131521962	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	3259140	131521962	111677411	25	34499											
LRP1B	53353	broad.mit.edu	37	chr2	141208173	141208173	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcagatccatcaccacagtCatccacggtgtcacatttcc	11	10	5	15	1	4	1	4	0	0	1	7	1	7	1	4	1	0	0	4	1	0	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr2:141208173C>A	uc002tvj.1	-	63	10993	c.10021G>T	c.(10021-10023)GAC>TAC	p.D3341Y		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3341	Extracellular (Potential).|LDL-receptor class A 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCACCACAGTCATCCACGGTG	0.358										TSP Lung(27;0.18)			18	51					8.34094e-07	9.75124e-07	1	0	A	141208173	A	A	141208173	3	1	186	1	0	0	0	0	1	0	0	0	9005	826	29	2	3894	2	LRP1B	2	141208173	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	9686211	141208173	101991200	26	34500											
TTN	7273	broad.mit.edu	37	chr2	179395327	179395327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgagctcataggtaccatCtgctgaataatgaaactgga	13	12	9	7	0	2	3	1	3	1	0	2	4	2	4	1	2	4	3	1	2	5	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr2:179395327C>T	uc010zfg.1	-	307	98535	c.98311G>A	c.(98311-98313)GAT>AAT	p.D32771N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D26466N|TTN_uc010zfi.1_Missense_Mutation_p.D26399N|TTN_uc010zfj.1_Missense_Mutation_p.D26274N|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33698							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGGTACCATCTGCTGAATAA	0.393													3	61					0	0	0	0	T	179395327	T	T	179395327	3	4	186	1	0	0	0	0	1	0	0	0	16803	913	32	2	1984	2	TTN	2	179395327	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	38187154	179395327	63804046	27	34501											
SLC4A3	6508	broad.mit.edu	37	chr2	220501091	220501091	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgctgtgctcggcgtcctCttctctctgctgggagctca	3	12	11	15	3	4	0	1	0	3	0	7	1	5	1	2	2	3	4	2	2	0	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr2:220501091C>G	uc002vmp.3	+	15	2528	c.2259C>G	c.(2257-2259)CTC>CTG	p.L753L	SLC4A3_uc002vmo.3_Silent_p.L780L|SLC4A3_uc010fwm.2_Silent_p.L303L|SLC4A3_uc010fwn.1_Silent_p.L262L	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	753	Helical; (Potential).|Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCGGCGTCCTCTTCTCTCTGC	0.622													21	52					0	0	0	0	G	220501091	G	G	220501091	2	3	186	1	0	0	0	0	0	0	0	1	14719	900	32	2		2	SLC4A3	2	220501091	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	41105764	220501091	22698282	28	34502											
EPHA4	2043	broad.mit.edu	37	chr2	222347263	222347263	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacttccacagggtcggcacTtgctggggtcaccagctcca	7	8	11	15	1	1	0	1	0	0	0	4	0	3	0	3	4	2	3	3	4	0	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr2:222347263T>A	uc002vmq.2	-	5	1169	c.1127A>T	c.(1126-1128)AAG>ATG	p.K376M	EPHA4_uc002vmr.2_Missense_Mutation_p.K376M|EPHA4_uc010zlm.1_Missense_Mutation_p.K317M|EPHA4_uc010zln.1_Missense_Mutation_p.K376M	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	376	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GGGTCGGCACTTGCTGGGGTC	0.517													61	182					0	0	0	0	A	222347263	A	A	222347263	3	1	186	1	0	0	0	0	1	0	0	0	5193	1609	56	5	1885	5	EPHA4	2	222347263	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	1846172	222347263	20852110	29	34503											
SRGAP3	9901	broad.mit.edu	37	chr3	9027554	9027554	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatctggcgcctgcttgacCgtgttctgcctctcgagttc	4	13	10	14	3	3	1	0	1	3	0	5	2	3	1	3	1	2	3	3	1	0	3	rs147085328	byFrequency	TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:9027554C>A	uc003brf.1	-	22	3625	c.2949G>T	c.(2947-2949)ACG>ACT	p.T983T	SRGAP3_uc003brg.1_Silent_p.T959T	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	983	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CCTGCTTGACCGTGTTCTGCC	0.647			T	RAF1	pilocytic astrocytoma								15	46					1.52009e-12	2.02122e-12	1	0	A	9027554	A	A	9027554	2	1	186	1	0	0	0	0	0	0	0	1	15213	639	23	3		3	SRGAP3	3	9027554	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08		9027554	188994876	30	34504											
TGM4	7047	broad.mit.edu	37	chr3	44929184	44929184	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttgggtgtctccagggcCgaatcctagcatcgccaaac	8	9	10	14	2	1	0	0	0	1	0	4	1	2	0	5	2	2	1	5	2	3	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:44929184C>G	uc003coc.3	+	3	270	c.197C>G	c.(196-198)CCG>CGG	p.P66R	TGM4_uc003coa.2_Missense_Mutation_p.P66R|TGM4_uc003cob.2_Intron	NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	66					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TCTCCAGGGCCGAATCCTAGC	0.592													18	22					0	0	0	0	G	44929184	G	G	44929184	3	3	186	1	0	0	0	0	1	0	0	0	15898	652	23	3	207	3	TGM4	3	44929184	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	35901630	44929184	153093246	31	34505											
IP6K2	51447	broad.mit.edu	37	chr3	48725981	48725982	+	Frame_Shift_Ins	INS	-	A	A																															tcgggccgctccttgccatcINSataaatgaccagcagggagc																										TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:48725981_48725982insA	uc003cup.2	-	6	1249_1250	c.1005_1006insT	c.(1003-1008)TATGATfs	p.Y335fs	NCKIPSD_uc003cum.2_5'Flank|NCKIPSD_uc003cun.2_5'Flank|NCKIPSD_uc010hkh.1_5'Flank|IP6K2_uc003cuq.2_Frame_Shift_Ins_p.Y335fs	NM_001005909	NP_001005909	Q9UHH9	IP6K2_HUMAN	inositol hexaphosphate kinase 2 isoform a	335_336					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						TCCTTGCCATCATAAATGACCA	0.554													---	---	---								A	48725982	A	A	48725981	7	5	186	1	0	1	1	0	0	0	0	0	7828	826	29	0	278	0	IP6K2	3	48725981	Frame_Shift_Ins	INS	-	TCGA-CV-5978-01A-11D-1683-08	3796797	48725981	149296449	32	34506											
ACY1	95	broad.mit.edu	37	chr3	52021202	52021202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcctggcattccgggagaagGaatggcagaggtgaggcagc	10	6	17	8	1	0	3	0	1	0	2	2	5	2	4	2	6	1	3	2	6	2	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:52021202G>A	uc003dcp.2	+	10	758	c.697G>A	c.(697-699)GAA>AAA	p.E233K	ACY1_uc011bea.1_Missense_Mutation_p.E323K|ACY1_uc011beb.1_Missense_Mutation_p.E233K|ACY1_uc003dcq.2_Missense_Mutation_p.E233K	NM_000666	NP_000657	Q03154	ACY1_HUMAN	aminoacylase 1	233			E -> D (in ACY1D; loss of activity).		cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	CCGGGAGAAGGAATGGCAGAG	0.552													48	58					0	0	0	0	A	52021202	A	A	52021202	3	1	186	1	0	0	0	0	1	0	0	0	226	1175	41	2	731	2	ACY1	3	52021202	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	3295221	52021202	146001228	33	34507											
MYH15	22989	broad.mit.edu	37	chr3	108195314	108195314	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taggatggatcaagcactttAccaactcagaggagttaatg	14	10	10	7	0	2	1	2	0	0	1	2	4	2	4	1	3	3	2	1	3	5	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:108195314A>T	uc003dxa.1	-	13	1280	c.1223T>A	c.(1222-1224)GTA>GAA	p.V408E		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	408	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CAAGCACTTTACCAACTCAGA	0.383													4	34					0	0	0	0	T	108195314	T	T	108195314	3	4	186	1	0	0	0	0	1	0	0	0	10087	391	14	5	4737	5	MYH15	3	108195314	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08	56174112	108195314	89827116	34	34508											
MORC1	27136	broad.mit.edu	37	chr3	108688550	108688550	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcagctttttgttcatcTgctctgggcactgctccagc	4	17	8	12	0	4	0	2	0	2	0	5	0	5	0	1	1	4	5	1	1	0	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:108688550T>A	uc003dxl.2	-	26	2657	c.2570A>T	c.(2569-2571)CAG>CTG	p.Q857L	MORC1_uc011bhn.1_Missense_Mutation_p.Q836L	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	857					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TTTGTTCATCTGCTCTGGGCA	0.363													10	56					0	0	0	0	A	108688550	A	A	108688550	3	1	186	1	0	0	0	0	1	0	0	0	9754	1580	55	5	396	5	MORC1	3	108688550	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	493236	108688550	89333880	35	34509											
COL6A6	131873	broad.mit.edu	37	chr3	130282012	130282012	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcatcaccaaaatgatcagCagtctccccatagaggccga	13	8	7	13	1	4	2	3	1	1	1	5	3	4	2	4	1	1	1	4	1	3	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:130282012C>A	uc010htl.2	+	2	196	c.165C>A	c.(163-165)AGC>AGA	p.S55R		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	55	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AAATGATCAGCAGTCTCCCCA	0.502													22	118					7.45023e-12	9.59018e-12	1	0	A	130282012	A	A	130282012	3	1	186	1	0	0	0	0	1	0	0	0	3718	709	25	4	171	4	COL6A6	3	130282012	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	21593462	130282012	67740418	36	34510											
PLSCR2	57047	broad.mit.edu	37	chr3	146173132	146173132	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcaaggtaaaaggtctaGaccgcccacagcaatttcgg	12	8	9	12	2	2	1	1	0	1	1	4	1	3	1	3	3	1	2	3	3	5	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:146173132G>T	uc003evv.1	-	5	548	c.215C>A	c.(214-216)TCT>TAT	p.S72Y	PLSCR2_uc003evw.1_Missense_Mutation_p.S141Y	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	72	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						AAAAGGTCTAGACCGCCCACA	0.413													16	103					2.62699e-14	3.65363e-14	1	0	T	146173132	T	T	146173132	3	4	186	1	0	0	0	0	1	0	0	0	12165	942	33	2	475	2	PLSCR2	3	146173132	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	15891120	146173132	51849298	37	34511											
ZIC4	84107	broad.mit.edu	37	chr3	147113700	147113700	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaagaccttcccacacccCgggaaaggacaagggaaggg	14	2	13	12	1	0	1	0	0	0	1	1	4	1	4	4	4	0	1	4	4	4	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:147113700C>A	uc003ewd.1	-	3	900	c.627G>T	c.(625-627)CCG>CCT	p.P209P	ZIC4_uc003ewc.1_Silent_p.P139P|ZIC4_uc011bno.1_Silent_p.P259P	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	209	C2H2-type 3.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						TCCCACACCCCGGGAAAGGAC	0.532													18	107					6.94344e-10	8.70629e-10	1	0	A	147113700	A	A	147113700	2	1	186	1	0	0	0	0	0	0	0	1	17748	639	23	3		3	ZIC4	3	147113700	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	940568	147113700	50908730	38	34512											
GMPS	8833	broad.mit.edu	37	chr3	155623996	155623996	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcttacacatggagatagtgTagacaaagtagctgatggat	14	10	12	5	0	0	3	0	1	0	2	0	5	0	4	0	2	2	4	0	2	5	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:155623996T>C	uc003faq.2	+	5	805	c.470T>C	c.(469-471)GTA>GCA	p.V157A	GMPS_uc011bom.1_Missense_Mutation_p.V58A	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	157	Glutamine amidotransferase type-1.				glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGAGATAGTGTAGACAAAGTA	0.323			T	MLL	AML								90	109					0	0	0	0	C	155623996	C	C	155623996	3	2	186	1	0	0	0	0	1	0	0	0	6535	1638	57	5	488	5	GMPS	3	155623996	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	8510296	155623996	42398434	39	34513											
SMC4	10051	broad.mit.edu	37	chr3	160148867	160148867	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcgcaatctgcttcaagaAttaaaagttattcaagaaaa	18	11	5	7	1	3	2	2	0	1	2	4	2	3	2	0	0	1	3	0	0	9	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:160148867A>C	uc003fdh.2	+	20	3101	c.2988A>C	c.(2986-2988)GAA>GAC	p.E996D	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.E971D|SMC4_uc003fdj.2_Missense_Mutation_p.E996D|SMC4_uc010hwd.2_Intron|SMC4_uc003fdl.2_Missense_Mutation_p.E699D	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	996	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TGCTTCAAGAATTAAAAGTTA	0.328													12	100					0	0	0	0	C	160148867	C	C	160148867	3	2	186	1	0	0	0	0	1	0	0	0	14849	98	4	5	3062	5	SMC4	3	160148867	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08	4524871	160148867	37873563	40	34514											
SLC7A14	57709	broad.mit.edu	37	chr3	170198783	170198783	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcactctcaggttggtatcGaaggagcaagacacagacag	13	7	12	9	1	2	2	2	0	1	2	4	4	2	3	0	3	1	3	0	3	3	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:170198783G>A	uc003fgz.2	-	7	1604	c.1288C>T	c.(1288-1290)CGA>TGA	p.R430*	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	430						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			GGTTGGTATCGAAGGAGCAAG	0.512													8	82					0	0	0	0	A	170198783	A	A	170198783	4	1	186	1	0	0	0	0	0	1	0	0	14760	1066	37	1	1035	1	SLC7A14	3	170198783	Nonsense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	10049916	170198783	27823647	41	34515											
NAALADL2	254827	broad.mit.edu	37	chr3	175184932	175184932	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgttttctgttcttggggagGaacagcttttggcaatattg	7	17	12	5	0	2	0	0	0	2	0	2	2	2	2	0	4	2	4	0	4	3	8			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:175184932G>C	uc003fit.2	+	8	1580	c.1493G>C	c.(1492-1494)GGA>GCA	p.G498A	NAALADL2_uc003fiu.1_Missense_Mutation_p.G491A|NAALADL2_uc010hwy.1_Missense_Mutation_p.G272A|NAALADL2_uc010hwz.1_Missense_Mutation_p.G92A	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	498	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TCTTGGGGAGGAACAGCTTTT	0.388													7	102					0	0	0	0	C	175184932	C	C	175184932	3	2	186	1	0	0	0	0	1	0	0	0	10183	1174	41	2	1523	2	NAALADL2	3	175184932	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	4986149	175184932	22837498	42	34516											
CLDN16	10686	broad.mit.edu	37	chr3	190126229	190126229	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtcctgttggctcggaaTggctgggtctctgggttgct	2	15	16	8	1	1	0	0	0	1	0	4	1	2	1	1	6	1	5	1	6	1	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr3:190126229T>A	uc003fsi.2	+	4	787	c.719T>A	c.(718-720)ATG>AAG	p.M240K	CLDN16_uc010hze.2_Intron	NM_006580	NP_006571	Q9Y5I7	CLD16_HUMAN	claudin 16	240	Helical; (Potential).				calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		TGGCTCGGAATGGCTGGGTCT	0.388													6	240					0	0	0	0	A	190126229	A	A	190126229	3	1	186	1	0	0	0	0	1	0	0	0	3492	1464	51	5	733	5	CLDN16	3	190126229	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	14941297	190126229	7896201	43	34517											
COL25A1	84570	broad.mit.edu	37	chr4	110223145	110223145	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatctgggctcccggccccCtcctttccctgcgtgcttct	1	12	10	18	2	2	0	0	0	2	0	5	1	5	1	5	3	2	2	5	3	0	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr4:110223145C>T	uc003hze.1	-	2	562	c.31G>A	c.(31-33)GGG>AGG	p.G11R	COL25A1_uc003hzg.2_Missense_Mutation_p.G11R|COL25A1_uc003hzh.1_Missense_Mutation_p.G11R	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	11	Cytoplasmic (Potential).					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TCCCGGCCCCCTCCTTTCCCT	0.637													9	34					0	0	0	0	T	110223145	T	T	110223145	3	4	186	1	0	0	0	0	1	0	0	0	3699	681	24	4	2161	4	COL25A1	4	110223145	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08		110223145	80931131	44	34518											
TRPC3	7222	broad.mit.edu	37	chr4	122836027	122836027	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acacttgatagctatggtctGctcccttaggcctgagaggt	8	12	11	10	0	1	2	0	2	1	1	2	3	2	2	2	3	2	2	2	3	3	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr4:122836027G>A	uc003ieg.2	-	4	1323	c.1249C>T	c.(1249-1251)CAG>TAG	p.Q417*	TRPC3_uc010inr.2_Intron|TRPC3_uc003ief.2_Nonsense_Mutation_p.Q344*|TRPC3_uc011cgl.1_Nonsense_Mutation_p.Q81*	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	332	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						GCTATGGTCTGCTCCCTTAGG	0.547													5	26					0	0	0	0	A	122836027	A	A	122836027	4	1	186	1	0	0	0	0	0	1	0	0	16646	1328	46	4	1552	4	TRPC3	4	122836027	Nonsense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	12612882	122836027	68318249	45	34519											
KIAA1109	84162	broad.mit.edu	37	chr4	123249348	123249348	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtgaaggatcatgttctgtGttcagttctcccaaaactcc	10	13	8	10	0	4	1	2	1	2	0	6	2	5	2	2	1	1	3	2	1	3	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr4:123249348G>C	uc003ieh.2	+	64	11130	c.11085G>C	c.(11083-11085)GTG>GTC	p.V3695V	KIAA1109_uc003iem.2_Silent_p.V86V	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3695					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CATGTTCTGTGTTCAGTTCTC	0.438													8	65					0	0	0	0	C	123249348	C	C	123249348	2	2	186	1	0	0	0	0	0	0	0	1	8247	1364	48	4		4	KIAA1109	4	123249348	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	413321	123249348	67904928	46	34520											
PCDH10	57575	broad.mit.edu	37	chr4	134072460	134072460	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgactgaccgcgactcagagGagaatgggcaggtgcagtgc	10	6	16	9	2	1	4	1	2	0	2	1	6	1	4	1	3	2	2	1	3	1	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr4:134072460G>A	uc003iha.2	+	1	1991	c.1165G>A	c.(1165-1167)GAG>AAG	p.E389K	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.E389K	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	389	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CGACTCAGAGGAGAATGGGCA	0.597													15	111					0	0	0	0	A	134072460	A	A	134072460	3	1	186	1	0	0	0	0	1	0	0	0	11561	1175	41	2	1167	2	PCDH10	4	134072460	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	10823112	134072460	57081816	47	34521											
INPP4B	8821	broad.mit.edu	37	chr4	143191916	143191916	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtgccaaccactttgccaCcatctgaagttctgcaacaa	11	10	7	13	0	2	1	0	1	2	0	2	1	2	1	4	1	5	2	4	1	4	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr4:143191916C>G	uc003iix.3	-	11	1110	c.515G>C	c.(514-516)GGT>GCT	p.G172A	INPP4B_uc003iiw.3_Missense_Mutation_p.G172A|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_5'UTR|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Missense_Mutation_p.G43A	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	172					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					CACTTTGCCACCATCTGAAGT	0.448													4	55					0	0	0	0	G	143191916	G	G	143191916	3	3	186	1	0	0	0	0	1	0	0	0	7792	507	18	4	2327	4	INPP4B	4	143191916	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	9119456	143191916	47962360	48	34522											
USP38	84640	broad.mit.edu	37	chr4	144135671	144135671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattaagttccgttgtggttCactctggtatatcctctgaa	8	17	8	8	1	3	1	1	1	2	0	5	1	5	1	2	2	0	4	2	2	5	7			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr4:144135671C>T	uc003ijb.2	+	9	3076	c.2542C>T	c.(2542-2544)CAC>TAC	p.H848Y	USP38_uc003ija.3_Missense_Mutation_p.H848Y|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	848					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					CGTTGTGGTTCACTCTGGTAT	0.413													7	38					0	0	0	0	T	144135671	T	T	144135671	3	4	186	1	0	0	0	0	1	0	0	0	17137	826	29	2	2576	2	USP38	4	144135671	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	943755	144135671	47018605	49	34523											
TKTL2	84076	broad.mit.edu	37	chr4	164394370	164394370	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagattgtccaagttgtagtGggaggcaaaagcaaaagcct	14	8	13	6	0	0	1	0	0	0	1	1	3	1	2	2	2	2	4	2	2	6	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr4:164394370G>C	uc003iqp.3	-	1	678	c.517C>G	c.(517-519)CAC>GAC	p.H173D		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	173						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AAGTTGTAGTGGGAGGCAAAA	0.552													9	52					0	0	0	0	C	164394370	C	C	164394370	3	2	186	1	0	0	0	0	1	0	0	0	16002	1348	47	4	1367	4	TKTL2	4	164394370	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	20258699	164394370	26759906	50	34524											
GPM6A	2823	broad.mit.edu	37	chr4	176622906	176622906	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccccaggcatttgatacagCattcaaaacaccctgtagaa	14	8	6	13	0	1	2	1	1	0	1	1	2	1	2	3	1	3	3	3	1	5	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr4:176622906C>A	uc003iuf.2	-	2	854	c.50G>T	c.(49-51)TGC>TTC	p.C17F	GPM6A_uc011ckj.1_Missense_Mutation_p.C10F|GPM6A_uc003iug.2_Missense_Mutation_p.C17F|GPM6A_uc003iuh.2_Missense_Mutation_p.C6F	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	17	Cytoplasmic (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		TTTGATACAGCATTCAAAACA	0.428													8	73					0.000157383	0.000171562	1	0	A	176622906	A	A	176622906	3	1	186	1	0	0	0	0	1	0	0	0	6653	710	25	4	810	4	GPM6A	4	176622906	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	12228536	176622906	14531370	51	34525											
WDR17	116966	broad.mit.edu	37	chr4	177071267	177071267	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatattagacaggaaatagaAaaactaactgctaattctca	19	10	6	6	0	1	2	1	0	1	2	2	4	1	3	0	1	3	1	0	1	8	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr4:177071267A>G	uc003iuj.2	+	16	2349	c.2193A>G	c.(2191-2193)GAA>GAG	p.E731E	WDR17_uc003iuk.2_Silent_p.E707E|WDR17_uc003ium.3_Silent_p.E707E|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_5'Flank	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	731										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		AGGAAATAGAAAAACTAACTG	0.348													8	29					0	0	0	0	G	177071267	G	G	177071267	2	3	186	1	0	0	0	0	0	0	0	1	17345	11	1	5		5	WDR17	4	177071267	Silent	SNP	A	TCGA-CV-5978-01A-11D-1683-08	448361	177071267	14083009	52	34526											
CTNND2	1501	broad.mit.edu	37	chr5	10992697	10992697	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagacacgcgcacaggggaGatggagggcgtgcgggagga	10	2	22	7	4	0	2	0	0	0	2	0	7	0	5	0	7	1	1	0	7	0	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr5:10992697G>C	uc003jfa.1	-	19	3322	c.3177C>G	c.(3175-3177)ATC>ATG	p.I1059M	CTNND2_uc010itt.2_Missense_Mutation_p.I968M|CTNND2_uc011cmy.1_Missense_Mutation_p.I722M|CTNND2_uc011cmz.1_Missense_Mutation_p.I626M|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.I651M	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1059					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GCACAGGGGAGATGGAGGGCG	0.577													31	59					0	0	0	0	C	10992697	C	C	10992697	3	2	186	1	0	0	0	0	1	0	0	0	4037	932	33	2	516	2	CTNND2	5	10992697	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08		10992697	169922563	53	34527											
CTNND2	1501	broad.mit.edu	37	chr5	11111052	11111052	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccattggcctcgccacagAgtagcccgtccagctcgtcc	6	8	10	17	3	0	1	0	0	0	1	4	1	2	1	6	1	3	2	6	1	1	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr5:11111052A>C	uc003jfa.1	-	14	2526	c.2381T>G	c.(2380-2382)CTC>CGC	p.L794R	CTNND2_uc010itt.2_Missense_Mutation_p.L703R|CTNND2_uc011cmy.1_Missense_Mutation_p.L457R|CTNND2_uc011cmz.1_Missense_Mutation_p.L361R|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.L361R	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	794					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CTCGCCACAGAGTAGCCCGTC	0.552													34	224					0	0	0	0	C	11111052	C	C	11111052	3	2	186	1	0	0	0	0	1	0	0	0	4037	304	11	5	1332	5	CTNND2	5	11111052	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08	118355	11111052	169804208	54	34528											
CTNND2	1501	broad.mit.edu	37	chr5	11565132	11565132	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggctacgatctgccgttcagCctccagctctcgggtcagcc	5	9	11	16	3	4	0	2	0	2	0	6	1	5	0	4	2	5	3	4	2	1	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr5:11565132C>T	uc003jfa.1	-	3	356	c.211G>A	c.(211-213)GCT>ACT	p.A71T	CTNND2_uc010itt.2_5'UTR|CTNND2_uc011cmy.1_5'UTR|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	71	Potential.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGCCGTTCAGCCTCCAGCTCT	0.502													6	38					0	0	0	0	T	11565132	T	T	11565132	3	4	186	1	0	0	0	0	1	0	0	0	4037	739	26	4	3546	4	CTNND2	5	11565132	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	454080	11565132	169350128	55	34529											
DNAH5	1767	broad.mit.edu	37	chr5	13717426	13717426	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagcatgcgcggcagtacctTtttgacatccatgtcatcca	9	11	8	13	2	1	1	1	1	0	0	3	1	3	1	3	1	3	3	3	1	1	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr5:13717426T>G	uc003jfd.2	-	73	12745	c.12703A>C	c.(12703-12705)AAG>CAG	p.K4235Q	DNAH5_uc003jfc.2_Missense_Mutation_p.K403Q	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4235					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGCAGTACCTTTTTGACATCC	0.507									Kartagener_syndrome				3	18					0	0	0	0	G	13717426	G	G	13717426	3	3	186	1	0	0	0	0	1	0	0	0	4626	1850	64	5	1199	5	DNAH5	5	13717426	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	2152294	13717426	167197834	56	34530											
DNAH5	1767	broad.mit.edu	37	chr5	13788883	13788883	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgtgtcaattccacaatcCaccaagagttttttctcttc	10	16	4	11	0	2	1	1	0	1	1	6	1	4	1	3	0	0	1	3	0	4	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr5:13788883C>T	uc003jfd.2	-	51	8631	c.8589G>A	c.(8587-8589)GTG>GTA	p.V2863V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2863					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTCCACAATCCACCAAGAGTT	0.413									Kartagener_syndrome				38	86					0	0	0	0	T	13788883	T	T	13788883	2	4	186	1	0	0	0	0	0	0	0	1	4626	581	21	4		4	DNAH5	5	13788883	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	71457	13788883	167126377	57	34531											
DNAH5	1767	broad.mit.edu	37	chr5	13864670	13864670	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttccagcagcgggcaacactCgctgaaatcatcaatgatct	12	9	8	12	2	3	2	2	2	1	0	5	2	4	2	1	1	3	3	1	1	3	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr5:13864670C>T	uc003jfd.2	-	28	4474	c.4432G>A	c.(4432-4434)GAG>AAG	p.E1478K		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1478	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGGCAACACTCGCTGAAATCA	0.527									Kartagener_syndrome				9	45					0	0	0	0	T	13864670	T	T	13864670	3	4	186	1	0	0	0	0	1	0	0	0	4626	893	31	1	9650	1	DNAH5	5	13864670	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	75787	13864670	167050590	58	34532											
DNAH5	1767	broad.mit.edu	37	chr5	13885171	13885171	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtattccttgtaactttcagAagagcatccatgttctgatg	10	15	8	8	0	2	3	1	1	1	2	4	3	4	3	2	0	2	4	2	0	3	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr5:13885171A>C	uc003jfd.2	-	19	2952	c.2910T>G	c.(2908-2910)CTT>CTG	p.L970L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	970	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TAACTTTCAGAAGAGCATCCA	0.418									Kartagener_syndrome				21	83					0	0	0	0	C	13885171	C	C	13885171	2	2	186	1	0	0	0	0	0	0	0	1	4626	233	9	5		5	DNAH5	5	13885171	Silent	SNP	A	TCGA-CV-5978-01A-11D-1683-08	20501	13885171	167030089	59	34533											
CDH18	1016	broad.mit.edu	37	chr5	19721468	19721468	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactaacctgttttagggtCgacggagaagtagggttgtc	9	11	14	7	2	0	1	0	0	0	1	2	3	0	1	1	3	1	4	1	3	4	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr5:19721468C>A	uc003jgc.2	-	4	1008	c.631G>T	c.(631-633)GAC>TAC	p.D211Y	CDH18_uc003jgd.2_Missense_Mutation_p.D211Y|CDH18_uc011cnm.1_Missense_Mutation_p.D211Y	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	211	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GTTTTAGGGTCGACGGAGAAG	0.448													30	72					9.65021e-13	1.29025e-12	1	0	A	19721468	A	A	19721468	3	1	186	1	0	0	0	0	1	0	0	0	3118	884	31	3	1777	3	CDH18	5	19721468	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	5836297	19721468	161193792	60	34534											
CDH12	1010	broad.mit.edu	37	chr5	21752180	21752180	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcgaattttgttctcctcaAtcacttttgggtttctcaga	7	18	7	9	1	4	1	3	0	2	1	6	2	4	1	1	1	1	2	1	1	2	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr5:21752180A>G	uc010iuc.2	-	12	2509	c.2051T>C	c.(2050-2052)ATT>ACT	p.I684T	CDH12_uc011cno.1_Missense_Mutation_p.I644T|CDH12_uc003jgk.2_Missense_Mutation_p.I684T|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	684	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GTTCTCCTCAATCACTTTTGG	0.458										HNSCC(59;0.17)			8	64					0	0	0	0	G	21752180	G	G	21752180	3	3	186	1	0	0	0	0	1	0	0	0	3113	101	4	5	337	5	CDH12	5	21752180	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08	2030712	21752180	159163080	61	34535											
PCDHGB3	56102	broad.mit.edu	37	chr5	140750005	140750005	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcccagcagggcagaggcGaatgctatttctcttcctgc	7	9	13	12	1	1	1	0	0	1	1	3	2	2	1	2	3	3	3	2	3	2	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr5:140750005G>T	uc003ljw.1	+	1	44	c.44G>T	c.(43-45)CGA>CTA	p.R15L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Missense_Mutation_p.R15L	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	15					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCAGAGGCGAATGCTATTT	0.552													17	31					1.15088e-07	1.37877e-07	1	0	T	140750005	T	T	140750005	3	4	186	1	0	0	0	0	1	0	0	0	11618	1058	37	3	46	3	PCDHGB3	5	140750005	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	118997825	140750005	40165255	62	34536											
HIST1H3H	8357	broad.mit.edu	37	chr6	27777865	27777865	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaaggcatggcgcgtacgaAgcagactgctcgcaagtcca	11	6	13	11	4	0	2	0	1	0	1	2	3	1	2	1	2	3	5	1	2	4	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr6:27777865A>T	uc003njm.2	+	1	24	c.14A>T	c.(13-15)AAG>ATG	p.K5M	HIST1H2BL_uc003njl.2_5'Flank	NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h	5					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GCGCGTACGAAGCAGACTGCT	0.567													20	35					0	0	0	0	T	27777865	T	T	27777865	3	4	186	1	0	0	0	0	1	0	0	0	7201	72	3	5	16	5	HIST1H3H	6	27777865	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08		27777865	143337202	63	34537											
SNRPC	6631	broad.mit.edu	37	chr6	34741320	34741320	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccatgatggtgcccactcgGcccggaatgactcgaccaga	9	6	11	15	3	0	3	0	2	0	1	2	5	0	4	4	3	1	0	4	3	1	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr6:34741320G>A	uc003ojt.1	+	6	468	c.453G>A	c.(451-453)CGG>CGA	p.R151R		NM_003093	NP_003084	P09234	RU1C_HUMAN	small nuclear ribonucleoprotein polypeptide C	151					spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			pancreas(1)	1						TGCCCACTCGGCCCGGAATGA	0.557													10	47					0	0	0	0	A	34741320	A	A	34741320	2	1	186	1	0	0	0	0	0	0	0	1	14927	1190	42	4		4	SNRPC	6	34741320	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	6963455	34741320	136373747	64	34538											
ZNF318	24149	broad.mit.edu	37	chr6	43325349	43325349	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgatatggggactataatCagatcgatgcaggaaagttt	14	11	11	5	1	1	2	1	1	0	1	2	5	1	4	0	3	1	2	0	3	4	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr6:43325349C>T	uc003oux.2	-	3	781	c.703G>A	c.(703-705)GAT>AAT	p.D235N	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	235					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GGACTATAATCAGATCGATGC	0.458													13	91					0	0	0	0	T	43325349	T	T	43325349	3	4	186	1	0	0	0	0	1	0	0	0	17903	826	29	2	6168	2	ZNF318	6	43325349	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	8584029	43325349	127789718	65	34539											
POLR1C	9533	broad.mit.edu	37	chr6	43488440	43488440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcaccctgcttgagcccGtggaaggggaggcagctgag	9	6	15	11	1	1	2	1	2	0	0	1	4	1	4	2	4	3	3	2	4	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr6:43488440G>A	uc003ovn.2	+	7	790	c.733G>A	c.(733-735)GTG>ATG	p.V245M	POLR1C_uc003ovo.1_Missense_Mutation_p.V245M	NM_203290	NP_976035	O15160	RPAC1_HUMAN	RNA polymerase I subunit isoform 1	245					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GCTTGAGCCCGTGGAAGGGGA	0.537													6	105					0	0	0	0	A	43488440	A	A	43488440	3	1	186	1	0	0	0	0	1	0	0	0	12266	1145	40	1	759	1	POLR1C	6	43488440	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	163091	43488440	127626627	66	34540											
MUT	4594	broad.mit.edu	37	chr6	49425487	49425487	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtatttcgaaccataaattCctttagtatatcattttgga	12	18	5	6	1	1	0	1	0	0	0	3	2	2	1	2	1	1	2	2	1	7	10			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr6:49425487C>A	uc003ozg.3	-	3	925	c.670G>T	c.(670-672)GAA>TAA	p.E224*		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	224					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCATAAATTCCTTTAGTATA	0.328													17	25					8.60227e-14	1.18281e-13	1	0	A	49425487	A	A	49425487	4	1	186	1	0	0	0	0	0	1	0	0	10044	864	30	2	1626	2	MUT	6	49425487	Nonsense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	5937047	49425487	121689580	67	34541											
RIMS1	22999	broad.mit.edu	37	chr6	72892001	72892001	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcatagaaagaagaccccagGgctttccgagcagaatggca	14	6	11	10	1	1	4	1	0	0	4	2	5	2	4	3	2	1	3	3	2	4	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr6:72892001G>C	uc003pga.2	+	6	904	c.827G>C	c.(826-828)GGG>GCG	p.G276A	RIMS1_uc011dyb.1_5'UTR|RIMS1_uc003pgc.2_5'UTR|RIMS1_uc003pgb.3_5'UTR	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	276					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AAGACCCCAGGGCTTTCCGAG	0.488													17	38					0	0	0	0	C	72892001	C	C	72892001	3	2	186	1	0	0	0	0	1	0	0	0	13432	1232	43	4	849	4	RIMS1	6	72892001	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	23466514	72892001	98223066	68	34542											
FUT9	10690	broad.mit.edu	37	chr6	96651233	96651233	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttaatgaaactactattctgGtgtgggtgtggccatttggg	8	15	13	5	0	1	1	0	1	1	0	1	1	1	1	1	4	2	0	1	4	4	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr6:96651233G>T	uc003pop.3	+	3	543	c.202G>T	c.(202-204)GTG>TTG	p.V68L		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	68	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		TACTATTCTGGTGTGGGTGTG	0.438													15	61					4.7546e-09	5.84068e-09	1	0	T	96651233	T	T	96651233	3	4	186	1	0	0	0	0	1	0	0	0	6145	1261	44	4	204	4	FUT9	6	96651233	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	23759232	96651233	74463834	69	34543											
GRIK2	2898	broad.mit.edu	37	chr6	102074485	102074485	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttttcaagtggaaaaccGtcacggttgtgtatgatgac	11	13	11	6	2	2	2	2	2	0	0	2	3	2	3	1	2	1	3	1	2	4	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr6:102074485G>T	uc003pqp.3	+	3	763	c.514G>T	c.(514-516)GTC>TTC	p.V172F	GRIK2_uc003pqn.2_Missense_Mutation_p.V172F|GRIK2_uc003pqo.3_Missense_Mutation_p.V172F|GRIK2_uc010kcw.2_Missense_Mutation_p.V172F	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	172	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GTGGAAAACCGTCACGGTTGT	0.408													10	47					5.50884e-06	6.28839e-06	1	0	T	102074485	T	T	102074485	3	4	186	1	0	0	0	0	1	0	0	0	6813	1145	40	3	524	3	GRIK2	6	102074485	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	5423252	102074485	69040582	70	34544											
ZBTB24	9841	broad.mit.edu	37	chr6	109787534	109787534	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagagttgatatggctgtagCtgaagaatattcctgacctc	11	12	11	7	0	0	5	0	3	0	2	2	6	1	5	2	1	1	4	2	1	5	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr6:109787534C>A	uc003ptl.1	-	7	1782	c.1614G>T	c.(1612-1614)CAG>CAT	p.Q538H	MICAL1_uc011eaq.1_5'Flank|ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.Q482H|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	538					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		ATGGCTGTAGCTGAAGAATAT	0.453													25	52					3.1745e-13	4.29178e-13	1	0	A	109787534	A	A	109787534	3	1	186	1	0	0	0	0	1	0	0	0	17598	796	28	4	483	4	ZBTB24	6	109787534	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	7713049	109787534	61327533	71	34545											
DNAH11	8701	broad.mit.edu	37	chr7	21678667	21678667	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acttgacattctctcaaaagGagctcagcctaaacaggtaa	15	9	7	10	0	3	1	2	1	1	0	4	2	3	2	1	2	3	2	1	2	5	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr7:21678667G>A	uc003svc.2	+	28	4974	c.4943G>A	c.(4942-4944)GGA>GAA	p.G1648E		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1648	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTCTCAAAAGGAGCTCAGCCT	0.403									Kartagener_syndrome				22	17					0	0	0	0	A	21678667	A	A	21678667	3	1	186	1	0	0	0	0	1	0	0	0	4621	1174	41	2	5053	2	DNAH11	7	21678667	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08		21678667	137459996	72	34546											
SRRM3	222183	broad.mit.edu	37	chr7	75912371	75912371	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagctactcgcccatccgcaAgcggcgccgggactcgccaa	8	4	11	18	6	0	0	0	0	0	0	3	1	1	1	4	2	3	2	4	2	3	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr7:75912371A>G	uc010ldi.2	+	14	1894	c.1685A>G	c.(1684-1686)AAG>AGG	p.K562R	SRRM3_uc003uet.1_5'UTR	NM_001110199	NP_001103669			serine/arginine repetitive matrix 3												0						CCCATCCGCAAGCGGCGCCGG	0.761													4	11					0	0	0	0	G	75912371	G	G	75912371	3	3	186	1	0	0	0	0	1	0	0	0	15236	72	3	5	1735	5	SRRM3	7	75912371	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08	54233704	75912371	83226292	73	34547											
CACNA2D1	781	broad.mit.edu	37	chr7	81626562	81626562	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttactggctcctgagatttgGggttctacacagaaaacaat	12	12	9	8	0	1	2	0	1	1	2	2	3	2	2	1	3	3	2	1	3	5	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr7:81626562G>T	uc003uhr.1	-	19	1851	c.1595C>A	c.(1594-1596)CCC>CAC	p.P532H		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	551	Extracellular (Potential).|Cache.					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTGAGATTTGGGGTTCTACAC	0.333													23	89					5.45024e-15	7.75858e-15	1	0	T	81626562	T	T	81626562	3	4	186	1	0	0	0	0	1	0	0	0	2560	1232	43	4	1764	4	CACNA2D1	7	81626562	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	5714191	81626562	77512101	74	34548											
CUX1	1523	broad.mit.edu	37	chr7	101747722	101747723	+	Frame_Shift_Ins	INS	-	T	T																															aacagaagttacagaatgacINStttgcagaaaaggagaggtg																										TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr7:101747722_101747723insT	uc003uyx.3	+	6	551_552	c.513_514insT	c.(511-516)GACTTTfs	p.D171fs	CUX1_uc003uys.3_Frame_Shift_Ins_p.D182fs|CUX1_uc003uyt.2_Frame_Shift_Ins_p.D182fs|CUX1_uc011kkn.1_Frame_Shift_Ins_p.D145fs|CUX1_uc003uyw.2_Frame_Shift_Ins_p.D136fs|CUX1_uc003uyv.2_Frame_Shift_Ins_p.D166fs|CUX1_uc003uyu.2_Frame_Shift_Ins_p.D182fs	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	171_172	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						TACAGAATGACTTTGCAGAAAA	0.421													---	---	---								T	101747723	T	T	101747722	7	5	186	1	0	1	1	0	0	0	0	0	4081	564	20	0	602	0	CUX1	7	101747722	Frame_Shift_Ins	INS	-	TCGA-CV-5978-01A-11D-1683-08	20121160	101747722	57390941	75	34549											
COG5	10466	broad.mit.edu	37	chr7	106898718	106898718	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacttaataaaatagttacCtttgttactgattggtgcaa	15	15	6	5	0	0	1	0	1	0	0	0	1	0	1	1	1	4	3	1	1	8	7			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr7:106898718C>T	uc003ved.2	-	15	2304	c.1779G>A	c.(1777-1779)AAG>AAA	p.K593K	COG5_uc003vec.2_Silent_p.K593K|COG5_uc003vee.2_Silent_p.K593K	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	593					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						aaataGTTACCTTTGTTACTG	0.303													8	80					0	0	0	0	T	106898718	T	T	106898718	2	4	186	1	0	0	0	0	0	0	0	1	3676	695	24	4		4	COG5	7	106898718	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	5150996	106898718	52239945	76	34550											
SSPO	23145	broad.mit.edu	37	chr7	149522074	149522074	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcatgccagtggagtctgTgggggccatggagcccctgc	6	8	15	12	0	2	0	1	0	1	0	2	2	2	2	4	4	3	0	4	4	0	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr7:149522074T>C	uc010lpk.2	+	97	13861	c.13861T>C	c.(13861-13863)TGG>CGG	p.W4621R	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_Intron|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4621	TSP type-1 23.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTGGAGTCTGTGGGGGCCATG	0.647													3	10					0	0	0	0	C	149522074	C	C	149522074	3	2	186	1	0	0	0	0	1	0	0	0	15255	1696	59	5	14237	5	SSPO	7	149522074	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	42623356	149522074	9616589	77	34551											
CSMD1	64478	broad.mit.edu	37	chr8	2855570	2855570	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggctactccactggccgttGctccgacactgggctcgaga	6	8	13	14	3	0	1	0	0	0	1	3	3	2	1	3	3	2	4	3	3	1	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:2855570G>A	uc011kwk.1	-	54	8733	c.8343C>T	c.(8341-8343)AGC>AGT	p.S2781S	CSMD1_uc011kwj.1_Silent_p.S2110S|CSMD1_uc010lrg.2_Silent_p.S791S	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2781	Extracellular (Potential).|Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACTGGCCGTTGCTCCGACACT	0.547													6	40					0	0	0	0	A	2855570	A	A	2855570	2	1	186	1	0	0	0	0	0	0	0	1	3961	1310	46	4		4	CSMD1	8	2855570	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08		2855570	143508452	78	34552											
PPP1R3B	79660	broad.mit.edu	37	chr8	8998840	8998840	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatccagaacaaagctctCgctctctgctgtcgtcaagc	12	9	7	13	2	3	1	1	0	2	1	7	1	4	1	1	0	4	3	1	0	5	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:8998840C>A	uc003wsn.3	-	2	487	c.322G>T	c.(322-324)GAG>TAG	p.E108*	PPP1R3B_uc003wso.3_Nonsense_Mutation_p.E107*	NM_024607	NP_078883	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	108					glycogen metabolic process					ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		ACAAAGCTCTCGCTCTCTGCT	0.478													12	56					5.50884e-06	6.28839e-06	1	0	A	8998840	A	A	8998840	4	1	186	1	0	0	0	0	0	1	0	0	12432	893	31	3	539	3	PPP1R3B	8	8998840	Nonsense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	6143270	8998840	137365182	79	34553											
DLC1	10395	broad.mit.edu	37	chr8	12943411	12943411	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcacacaaatgtccaaaaGattttgtgtaccattctggc	12	12	7	10	0	1	1	0	0	1	1	2	1	2	1	2	1	2	2	2	1	4	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:12943411G>T	uc003wwm.2	-	18	4940	c.4496C>A	c.(4495-4497)TCT>TAT	p.S1499Y	DLC1_uc003wwk.1_Missense_Mutation_p.S1062Y|DLC1_uc003wwl.1_Missense_Mutation_p.S1096Y|DLC1_uc011kxx.1_Missense_Mutation_p.S988Y	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1499	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						ATGTCCAAAAGATTTTGTGTA	0.378													20	49					1.01871e-10	1.29072e-10	1	0	T	12943411	T	T	12943411	3	4	186	1	0	0	0	0	1	0	0	0	4572	942	33	2	94	2	DLC1	8	12943411	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	3944571	12943411	133420611	80	34554											
MSR1	4481	broad.mit.edu	37	chr8	15978072	15978072	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatctccaccctcccctcGtgagggccgctcccaccgac	6	7	8	20	3	1	1	0	1	1	0	5	2	3	1	7	1	0	2	7	1	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:15978072G>T	uc003wwz.2	-	9	1275	c.1077C>A	c.(1075-1077)CAC>CAA	p.H359Q	MSR1_uc010lsu.2_Missense_Mutation_p.H377Q|MSR1_uc003wxa.2_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	359	SRCR.|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCCTCCCCTCGTGAGGGCCGC	0.483													26	65					1.75199e-13	2.39537e-13	1	0	T	15978072	T	T	15978072	3	4	186	1	0	0	0	0	1	0	0	0	9939	1136	40	3	286	3	MSR1	8	15978072	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	3034661	15978072	130385950	81	34555											
TEX15	56154	broad.mit.edu	37	chr8	30705035	30705035	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatcctgctttttgtctccaTatatgttctctatgttgttt	6	22	5	8	0	2	0	0	0	2	0	5	0	3	0	2	0	1	4	2	0	4	8			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:30705035T>C	uc003xil.2	-	1	1499	c.1499A>G	c.(1498-1500)TAT>TGT	p.Y500C		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	500										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTTGTCTCCATATATGTTCTC	0.308													18	88					0	0	0	0	C	30705035	C	C	30705035	3	2	186	1	0	0	0	0	1	0	0	0	15845	1406	49	5	6886	5	TEX15	8	30705035	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	14726963	30705035	115658987	82	34556											
LETM2	137994	broad.mit.edu	37	chr8	38261968	38261968	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttttgctcctgtcccgcAccttctacctgatagatgtg	5	14	7	15	1	1	2	0	1	1	1	3	2	3	2	5	0	2	2	5	0	2	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:38261968A>T	uc003xlm.1	+	8	1192	c.1021A>T	c.(1021-1023)ACC>TCC	p.T341S	LETM2_uc011lbn.1_Missense_Mutation_p.T185S|LETM2_uc003xll.1_Missense_Mutation_p.T293S|LETM2_uc003xln.1_Missense_Mutation_p.T185S|LETM2_uc003xlo.1_Missense_Mutation_p.T185S	NM_144652	NP_653253	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane	388	Mitochondrial matrix (Potential).					integral to membrane|mitochondrial inner membrane					0	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			CCTGTCCCGCACCTTCTACCT	0.557													20	45					0	0	0	0	T	38261968	T	T	38261968	3	4	186	1	0	0	0	0	1	0	0	0	8775	159	6	5	895	5	LETM2	8	38261968	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08	7556933	38261968	108102054	83	34557											
RB1CC1	9821	broad.mit.edu	37	chr8	53570560	53570560	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaaagaattgaatttgcctTttgttcactcagtagatctg	11	16	8	6	0	3	4	2	2	1	2	3	4	3	4	1	0	1	2	1	0	4	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:53570560T>A	uc003xre.3	-	14	2476	c.1918A>T	c.(1918-1920)AAG>TAG	p.K640*	RB1CC1_uc003xrf.3_Nonsense_Mutation_p.K640*	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	640					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				GAATTTGCCTTTTGTTCACTC	0.378													26	84					0	0	0	0	A	53570560	A	A	53570560	4	1	186	1	0	0	0	0	0	1	0	0	13164	1850	64	5	2910	5	RB1CC1	8	53570560	Nonsense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	15308592	53570560	92793462	84	34558											
KCNB2	9312	broad.mit.edu	37	chr8	73848938	73848938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaaaaggaacggaagcatcGtttctatgaacttaaaagat	17	9	8	7	2	1	2	0	1	1	1	2	4	1	4	1	2	3	2	1	2	8	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:73848938G>A	uc003xzb.2	+	3	1936	c.1348G>A	c.(1348-1350)GTT>ATT	p.V450I		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	450	Cytoplasmic (Potential).		V -> I (in a colorectal cancer sample; somatic mutation).		regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding	p.V450I(1)		skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CGGAAGCATCGTTTCTATGAA	0.473													30	89					0	0	0	0	A	73848938	A	A	73848938	3	1	186	1	0	0	0	0	1	0	0	0	8052	1145	40	1	1354	1	KCNB2	8	73848938	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	20278378	73848938	72515084	85	34559											
ODF1	4956	broad.mit.edu	37	chr8	103564144	103564144	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctattccaagcgatcacgCtcttgcggcctgtgtgatct	6	13	10	12	3	3	1	1	1	2	0	4	2	4	1	2	1	3	2	2	1	2	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:103564144C>G	uc003ykt.2	+	1	297	c.189C>G	c.(187-189)CGC>CGG	p.R63R		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	63	2 X 5 AA repeats of [RC]-C-L-C-D.				cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			AGCGATCACGCTCTTGCGGCC	0.493													42	110					0	0	0	0	G	103564144	G	G	103564144	2	3	186	1	0	0	0	0	0	0	0	1	10880	784	28	4		4	ODF1	8	103564144	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	29715206	103564144	42799878	86	34560											
CSMD3	114788	broad.mit.edu	37	chr8	113585863	113585863	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaagcacctagtagatgagtCgttttatcttttccatcata	12	15	6	8	1	2	2	1	1	1	1	4	2	3	2	2	0	1	3	2	0	5	7			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:113585863C>T	uc003ynu.2	-	24	4068	c.3909G>A	c.(3907-3909)ACG>ACA	p.T1303T	CSMD3_uc003yns.2_Silent_p.T575T|CSMD3_uc003ynt.2_Silent_p.T1263T|CSMD3_uc011lhx.1_Silent_p.T1199T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1303	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTAGATGAGTCGTTTTATCTT	0.318										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	77					0	0	0	0	T	113585863	T	T	113585863	2	4	186	1	0	0	0	0	0	0	0	1	3963	871	31	1		1	CSMD3	8	113585863	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	10021719	113585863	32778159	87	34561											
CSMD3	114788	broad.mit.edu	37	chr8	113599379	113599379	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaacctgaatactataaatGcattcatggttgttttcata	13	16	6	6	0	2	2	2	2	0	0	2	2	2	2	1	1	3	3	1	1	7	8			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:113599379G>T	uc003ynu.2	-	23	3960	c.3801C>A	c.(3799-3801)TGC>TGA	p.C1267*	CSMD3_uc003yns.2_Nonsense_Mutation_p.C539*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.C1227*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.C1163*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1267	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TACTATAAATGCATTCATGGT	0.383										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			24	66					2.21704e-12	2.91588e-12	1	0	T	113599379	T	T	113599379	4	4	186	1	0	0	0	0	0	1	0	0	3963	1311	46	4	7518	4	CSMD3	8	113599379	Nonsense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	13516	113599379	32764643	88	34562											
ENPP2	5168	broad.mit.edu	37	chr8	120629736	120629736	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatattaggcatgactttgcTgcctttcttcatgtatgatg	9	17	8	7	0	2	2	1	2	1	0	2	2	2	2	1	1	2	3	1	1	4	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:120629736T>A	uc003yot.1	-	6	633	c.547A>T	c.(547-549)AGC>TGC	p.S183C	ENPP2_uc003yos.1_Missense_Mutation_p.S183C|ENPP2_uc010mdd.1_Missense_Mutation_p.S183C	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	183					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATGACTTTGCTGCCTTTCTTC	0.398													9	27					0	0	0	0	A	120629736	A	A	120629736	3	1	186	1	0	0	0	0	1	0	0	0	5154	1580	55	5	2363	5	ENPP2	8	120629736	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	7030357	120629736	25734286	89	34563											
FAM135B	51059	broad.mit.edu	37	chr8	139164844	139164844	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagcagcaccatcttccccTcttgatctattccctttcct	6	16	3	16	0	3	1	0	1	3	0	6	1	6	1	5	0	2	2	5	0	2	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr8:139164844T>A	uc003yuy.2	-	13	2045	c.1874A>T	c.(1873-1875)GAG>GTG	p.E625V	FAM135B_uc003yux.2_Missense_Mutation_p.E526V|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.E187V|FAM135B_uc003yvb.2_Missense_Mutation_p.E187V	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	625										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CATCTTCCCCTCTTGATCTAT	0.463										HNSCC(54;0.14)			12	107					0	0	0	0	A	139164844	A	A	139164844	3	1	186	1	0	0	0	0	1	0	0	0	5477	1551	54	5	2378	5	FAM135B	8	139164844	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	18535108	139164844	7199178	90	34564											
KIAA1161	57462	broad.mit.edu	37	chr9	34370855	34370855	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaccgggtaatcggtgagcAgcaccggcgtcttgtcgaaa	9	7	14	11	6	1	1	0	1	1	0	3	3	1	1	2	3	2	3	2	3	2	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr9:34370855A>C	uc003zue.3	-	3	2254	c.2087T>G	c.(2086-2088)CTG>CGG	p.L696R		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	696	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		ATCGGTGAGCAGCACCGGCGT	0.637													13	15					0	0	0	0	C	34370855	C	C	34370855	3	2	186	1	0	0	0	0	1	0	0	0	8250	188	7	5	61	5	KIAA1161	9	34370855	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08		34370855	106842576	91	34565											
KIF27	55582	broad.mit.edu	37	chr9	86506407	86506407	+	Frame_Shift_Del	DEL	T	-	-																															aagaagttgttgttctattaTtttttcattctttgtagaag																										TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr9:86506407delT	uc004ana.2	-	6	1756	c.1612delA	c.(1612-1614)ATAfs	p.I538fs	KIF27_uc010mpw.2_Frame_Shift_Del_p.I538fs|KIF27_uc010mpx.2_Frame_Shift_Del_p.I538fs	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	538	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TGTTCTATTATTTTTTCATTC	0.303													---	---	---								-	86506407	-	-	86506407	7	5	186	1	0	1	0	1	0	0	0	0	8335	1493	52	0	2645	0	KIF27	9	86506407	Frame_Shift_Del	DEL	T	TCGA-CV-5978-01A-11D-1683-08	52135552	86506407	54707024	92	34566											
TGFBR1	7046	broad.mit.edu	37	chr9	101907135	101907135	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattcagccacagataccatTgatattgctccaaaccacag	14	9	6	12	0	1	2	1	1	0	1	2	3	2	2	4	0	4	1	4	0	3	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr9:101907135T>C	uc004azc.2	+	6	1171	c.1095T>C	c.(1093-1095)ATT>ATC	p.I365I	TGFBR1_uc004azd.2_Silent_p.I288I|TGFBR1_uc011lvc.1_Silent_p.I296I	NM_004612	NP_004603	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor I	365	Protein kinase.|Cytoplasmic (Potential).				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)				CAGATACCATTGATATTGCTC	0.348													15	56					0	0	0	0	C	101907135	C	C	101907135	2	2	186	1	0	0	0	0	0	0	0	1	15887	1800	63	5		5	TGFBR1	9	101907135	Silent	SNP	T	TCGA-CV-5978-01A-11D-1683-08	15400728	101907135	39306296	93	34567											
C9orf43	257169	broad.mit.edu	37	chr9	116185750	116185750	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctctctgggctcaatccGaagcgttacctcaggatcta	9	11	8	13	2	4	0	2	0	2	0	6	2	5	1	3	2	3	2	3	2	5	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr9:116185750G>T	uc004bho.3	+	7	1024	c.628G>T	c.(628-630)GAA>TAA	p.E210*	C9orf43_uc004bhp.2_Nonsense_Mutation_p.E210*	NM_152786	NP_689999	Q8TAL5	CI043_HUMAN	hypothetical protein LOC257169	210											0						GGCTCAATCCGAAGCGTTACC	0.498													4	35					0.00909568	0.00944702	1	0	T	116185750	T	T	116185750	4	4	186	1	0	0	0	0	0	1	0	0	2495	1059	37	3	650	3	C9orf43	9	116185750	Nonsense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	14278615	116185750	25027681	94	34568											
OR1N2	138882	broad.mit.edu	37	chr9	125315468	125315468	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catggaaggtttttatctgcGcagatcacacgaactacaag	13	10	9	9	2	2	1	1	0	1	1	2	3	2	2	0	2	3	2	0	2	5	4	rs141317564		TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr9:125315468G>A	uc011lyx.1	+	1	20	c.20G>A	c.(19-21)CGC>CAC	p.R7H		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						TTTTATCTGCGCAGATCACAC	0.313													9	66					0	0	0	0	A	125315468	A	A	125315468	3	1	186	1	0	0	0	0	1	0	0	0	11024	1087	38	1	22	1	OR1N2	9	125315468	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	9129718	125315468	15897963	95	34569											
DENND1A	57706	broad.mit.edu	37	chr9	126219701	126219701	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggaattgagaagatctaatCgaccatcaataaactataga	18	9	7	7	2	2	3	1	1	1	3	3	6	2	4	1	1	1	0	1	1	8	5	rs139898166		TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr9:126219701C>T	uc004bnz.1	-	15	1345	c.1112G>A	c.(1111-1113)CGA>CAA	p.R371Q	DENND1A_uc011lzl.1_Missense_Mutation_p.R146Q|DENND1A_uc004bny.1_Intron|DENND1A_uc011lzm.1_Missense_Mutation_p.R339Q|DENND1A_uc004boa.1_Missense_Mutation_p.R371Q|DENND1A_uc004bob.1_Missense_Mutation_p.R341Q|DENND1A_uc004boc.2_Missense_Mutation_p.R339Q	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	371	dDENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						AAGATCTAATCGACCATCAAT	0.433													7	98					0	0	0	0	T	126219701	T	T	126219701	3	4	186	1	0	0	0	0	1	0	0	0	4448	884	31	1	2056	1	DENND1A	9	126219701	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	904233	126219701	14993730	96	34570											
CIZ1	25792	broad.mit.edu	37	chr9	130941207	130941207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggatatgtctgtgtctggaCctgcttctgcagctgcagct	5	14	12	10	0	3	0	0	0	3	0	3	2	3	2	1	2	5	5	1	2	1	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr9:130941207C>T	uc004btt.2	-	8	1442	c.1279G>A	c.(1279-1281)GTC>ATC	p.V427I	CIZ1_uc004btr.2_Intron|CIZ1_uc004bts.2_Missense_Mutation_p.V398I|CIZ1_uc011maq.1_Intron|CIZ1_uc004btu.2_Intron|CIZ1_uc011mar.1_Missense_Mutation_p.V326I|CIZ1_uc011mas.1_Missense_Mutation_p.V457I|CIZ1_uc004btw.2_Intron|CIZ1_uc004btv.2_Missense_Mutation_p.V427I|CIZ1_uc004btx.2_Missense_Mutation_p.V403I	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	427	Gln-rich.					nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4						TGTGTCTGGACCTGCTTCTGC	0.468													5	119					0	0	0	0	T	130941207	T	T	130941207	3	4	186	1	0	0	0	0	1	0	0	0	3456	507	18	4	1457	4	CIZ1	9	130941207	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	4721506	130941207	10272224	97	34571											
FIBCD1	84929	broad.mit.edu	37	chr9	133799269	133799269	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtctcggggccgggagccTgagggaggcaaggctgtcag	7	5	19	10	2	2	1	1	1	1	0	3	3	2	3	2	6	1	2	2	6	1	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr9:133799269T>A	uc004bzz.2	-	4	958	c.713_splice	c.e4-1	p.G238_splice	FIBCD1_uc011mcc.1_Splice_Site_p.G238_splice	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1						signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		GCCGGGAGCCTGAGGGAGGCA	0.647													8	64					0	0	0	0	A	133799269	A	A	133799269	5	1	186	1	0	0	0	0	0	0	1	0	5916	1594	55	5	690	5	FIBCD1	9	133799269	Splice_Site	SNP	T	TCGA-CV-5978-01A-11D-1683-08	2858062	133799269	7414162	98	34572											
PTCHD3	374308	broad.mit.edu	37	chr10	27703080	27703080	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccttccgactccgattcctGagattcctggtaccactgcg	6	11	9	15	3	0	1	0	1	0	1	4	4	4	1	6	1	2	1	6	1	1	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr10:27703080G>A	uc001itu.2	-	1	218	c.100C>T	c.(100-102)CAG>TAG	p.Q34*		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	34					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TCCGATTCCTGAGATTCCTGG	0.682													19	112					0	0	0	0	A	27703080	A	A	27703080	4	1	186	1	0	0	0	0	0	1	0	0	12796	1299	45	2	2219	2	PTCHD3	10	27703080	Nonsense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08		27703080	107831667	99	34573											
AGAP6	414189	broad.mit.edu	37	chr10	51748544	51748544	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgaccagcagcaggggtcGgtgtgtccctctgaatctga	7	11	13	10	1	2	3	0	3	2	0	4	3	3	3	2	3	2	2	2	3	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr10:51748544G>T	uc001jix.3	+	1	467	c.69G>T	c.(67-69)TCG>TCT	p.S23S		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	23					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						AGCAGGGGTCGGTGTGTCCCT	0.607													30	38					2.08457e-15	2.985e-15	1	0	T	51748544	T	T	51748544	2	4	186	1	0	0	0	0	0	0	0	1	372	1103	39	3		3	AGAP6	10	51748544	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	24045464	51748544	83786203	100	34574											
GRID1	2894	broad.mit.edu	37	chr10	87482808	87482808	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgaggaaggcagcaaggttgGctgtgtaggaggagcacaca	12	6	17	6	0	0	1	0	1	0	0	0	4	0	4	0	6	2	6	0	6	3	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr10:87482808G>T	uc001kdl.1	-	12	2050	c.1949C>A	c.(1948-1950)GCC>GAC	p.A650D	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.A221D	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	650	Helical; (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGCAAGGTTGGCTGTGTAGGA	0.562										Multiple Myeloma(13;0.14)			7	21					8.12818e-05	8.941e-05	1	0	T	87482808	T	T	87482808	3	4	186	1	0	0	0	0	1	0	0	0	6810	1203	42	4	1100	4	GRID1	10	87482808	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	35734264	87482808	48051939	101	34575											
HPSE2	60495	broad.mit.edu	37	chr10	100904156	100904156	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacatcacttcgaacaatgTctacaaaaagaaagaaagaa	22	6	5	8	1	2	3	1	0	1	3	3	4	2	3	0	0	3	0	0	0	9	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr10:100904156T>A	uc001kpn.1	-	3	509	c.449A>T	c.(448-450)GAC>GTC	p.D150V	HPSE2_uc009xwc.1_Missense_Mutation_p.D140V|HPSE2_uc001kpo.1_Missense_Mutation_p.D140V|HPSE2_uc009xwd.1_Intron	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	150					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TCGAACAATGTCTACAAAAAG	0.388													12	58					0	0	0	0	A	100904156	A	A	100904156	3	1	186	1	0	0	0	0	1	0	0	0	7384	1681	58	5	1407	5	HPSE2	10	100904156	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	13421348	100904156	34630591	102	34576											
WNT8B	7479	broad.mit.edu	37	chr10	102239717	102239717	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cagtttgcctgggaccgctgGaactgccctgagagagccct	7	8	13	13	1	0	2	0	1	0	1	0	5	0	4	4	2	4	2	4	2	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr10:102239717G>C	uc001krb.2	+	3	303	c.189G>C	c.(187-189)TGG>TGC	p.W63C		NM_003393	NP_003384	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family,	63					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(1)|breast(1)|large_intestine(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		GGGACCGCTGGAACTGCCCTG	0.557													16	29					0	0	0	0	C	102239717	C	C	102239717	3	2	186	1	0	0	0	0	1	0	0	0	17465	1183	41	2	199	2	WNT8B	10	102239717	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	1335561	102239717	33295030	103	34577											
NLRP6	171389	broad.mit.edu	37	chr11	284380	284380	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggcctagcctggccgcaGtgcagggtgcagacggtcag	7	5	18	11	2	1	1	1	0	0	1	1	2	1	1	3	4	3	3	3	4	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:284380G>C	uc010qvs.1	+	6	2352	c.2352G>C	c.(2350-2352)CAG>CAC	p.Q784H	NLRP6_uc010qvt.1_Missense_Mutation_p.Q783H	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	784						cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCTGGCCGCAGTGCAGGGTGC	0.701													11	17					0	0	0	0	C	284380	C	C	284380	3	2	186	1	0	0	0	0	1	0	0	0	10535	1020	36	4	2374	4	NLRP6	11	284380	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08		284380	134722136	104	34578											
OR10A3	26496	broad.mit.edu	37	chr11	7960207	7960207	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttcgtaagctatagatgagCggattgagcagaggggtaag	12	10	15	4	2	0	4	0	2	0	2	1	5	0	5	0	3	3	4	0	3	4	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:7960207C>T	uc010rbi.1	-	1	861	c.861G>A	c.(859-861)CCG>CCA	p.P287P		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TATAGATGAGCGGATTGAGCA	0.413													19	42					0	0	0	0	T	7960207	T	T	7960207	2	4	186	1	0	0	0	0	0	0	0	1	10945	755	27	1		1	OR10A3	11	7960207	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	7675827	7960207	127046309	105	34579											
MRGPRX3	117195	broad.mit.edu	37	chr11	18159486	18159486	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccaggatccacctggattGgaaagtcttattttgtcatg	9	15	9	8	0	2	0	1	0	1	0	4	3	4	3	3	3	0	0	3	3	2	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:18159486G>C	uc001mnu.2	+	3	1098	c.737G>C	c.(736-738)TGG>TCG	p.W246S		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	246	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						CACCTGGATTGGAAAGTCTTA	0.507													5	52					0	0	0	0	C	18159486	C	C	18159486	3	2	186	1	0	0	0	0	1	0	0	0	9821	1357	47	4	739	4	MRGPRX3	11	18159486	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	10199279	18159486	116847030	106	34580											
OR5F1	338674	broad.mit.edu	37	chr11	55761981	55761981	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggatcatcccgagatttcCcagtactgtaagtgtataaa	13	11	9	8	1	1	1	1	0	0	1	3	4	3	2	2	1	1	3	2	1	5	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:55761981C>T	uc010riv.1	-	1	121	c.121G>A	c.(121-123)GGA>AGA	p.G41R		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CCGAGATTTCCCAGTACTGTA	0.433													17	42					0	0	0	0	T	55761981	T	T	55761981	3	4	186	1	0	0	0	0	1	0	0	0	11212	632	22	4	826	4	OR5F1	11	55761981	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	37602495	55761981	79244535	107	34581											
OR9G4	283189	broad.mit.edu	37	chr11	56510760	56510760	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaatgcaggcggaatgtattGgcagtatgggctatggcatt	11	11	14	5	1	0	0	0	0	0	0	0	1	0	1	0	5	1	6	0	5	5	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:56510760G>A	uc010rjo.1	-	1	528	c.528C>T	c.(526-528)GCC>GCT	p.A176A		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GGAATGTATTGGCAGTATGGG	0.448													27	66					0	0	0	0	A	56510760	A	A	56510760	2	1	186	1	0	0	0	0	0	0	0	1	11305	1335	47	4		4	OR9G4	11	56510760	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	748779	56510760	78495756	108	34582											
GLYATL1	92292	broad.mit.edu	37	chr11	58715400	58715400	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggtgctggtggattcctggCctgaatatcagatggttatt	8	14	13	6	0	1	2	1	1	0	1	2	3	2	3	2	5	1	2	2	5	3	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:58715400C>A	uc001nnf.2	+	5	524	c.148C>A	c.(148-150)CCT>ACT	p.P50T	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.P81T|GLYATL1_uc001nni.1_Missense_Mutation_p.P50T|GLYATL1_uc001nnj.1_Missense_Mutation_p.P50T			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	50						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	GGATTCCTGGCCTGAATATCA	0.547													12	49					1.5842e-08	1.91688e-08	1	0	A	58715400	A	A	58715400	3	1	186	1	0	0	0	0	1	0	0	0	6517	739	26	4	255	4	GLYATL1	11	58715400	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	2204640	58715400	76291116	109	34583											
MRGPRF	116535	broad.mit.edu	37	chr11	68777336	68777336	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttaccttgttcctgttgcCgggatgggcctcccaggagc	5	11	12	13	1	0	0	0	0	0	0	2	2	2	2	5	3	3	2	5	3	1	4	rs143408398		TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:68777336C>T	uc001ooo.3	-	2	401	c.34G>A	c.(34-36)GGC>AGC	p.G12S	MRGPRF_uc001oop.3_Missense_Mutation_p.G12S|uc001ooq.2_5'Flank	NM_001098515	NP_001091985	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	12	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTCCTGTTGCCGGGATGGGCC	0.672													6	85					0	0	0	0	T	68777336	T	T	68777336	3	4	186	1	0	0	0	0	1	0	0	0	9818	652	23	1	1005	1	MRGPRF	11	68777336	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	10061936	68777336	66229180	110	34584											
DLG2	1740	broad.mit.edu	37	chr11	83770475	83770475	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcttccaccgctttactgtGggaaacctctgacacatcaa	10	10	8	13	1	2	1	1	1	1	0	3	2	3	2	3	2	2	2	3	2	3	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:83770475G>A	uc001paj.2	-	6	790	c.487C>T	c.(487-489)CAC>TAC	p.H163Y	DLG2_uc001pai.2_Missense_Mutation_p.H112Y|DLG2_uc010rsy.1_Missense_Mutation_p.H130Y|DLG2_uc010rsz.1_Missense_Mutation_p.H163Y|DLG2_uc010rta.1_Missense_Mutation_p.H163Y|DLG2_uc001pak.2_Missense_Mutation_p.H268Y|DLG2_uc010rtb.1_Missense_Mutation_p.H130Y|DLG2_uc001pal.1_Missense_Mutation_p.H163Y|DLG2_uc001pam.1_Missense_Mutation_p.H202Y	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	163	PDZ 1.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GCTTTACTGTGGGAAACCTCT	0.473													7	44					0	0	0	0	A	83770475	A	A	83770475	3	1	186	1	0	0	0	0	1	0	0	0	4577	1348	47	4	2247	4	DLG2	11	83770475	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	14993139	83770475	51236041	111	34585											
NOX4	50507	broad.mit.edu	37	chr11	89135493	89135493	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caaacacaaaattaatctgaCctgtggaaaattagcttgga	17	10	7	7	0	1	1	0	1	1	0	1	3	1	3	1	2	2	1	1	2	7	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:89135493C>A	uc001pct.2	-	9	1085	c.846_splice	c.e9+1	p.Q282_splice	NOX4_uc009yvr.2_Splice_Site_p.Q257_splice|NOX4_uc001pcu.2_Splice_Site_p.Q208_splice|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Splice_Site_p.Q282_splice|NOX4_uc009yvo.2_Intron|NOX4_uc010rtu.1_Splice_Site_p.Q116_splice|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Splice_Site_p.Q258_splice|NOX4_uc009yvq.2_Splice_Site_p.Q258_splice	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				ATTAATCTGACCTGTGGAAAA	0.353													10	46					0.000673444	0.000717945	1	0	A	89135493	A	A	89135493	5	1	186	1	0	0	0	0	0	0	1	0	10612	521	18	4	929	4	NOX4	11	89135493	Splice_Site	SNP	C	TCGA-CV-5978-01A-11D-1683-08	5365018	89135493	45871023	112	34586											
PDZD3	79849	broad.mit.edu	37	chr11	119059095	119059095	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggaggtggacccgggactGccagccaagaaggctgggat	9	5	18	9	1	0	1	0	0	0	1	0	5	0	5	3	6	2	1	3	6	2	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:119059095G>T	uc001pwb.2	+	6	1616	c.1092G>T	c.(1090-1092)CTG>CTT	p.L364L	PDZD3_uc001pvy.2_Silent_p.L284L|PDZD3_uc001pvz.2_Silent_p.L298L|PDZD3_uc010rzd.1_Silent_p.L285L|PDZD3_uc001pwa.2_5'UTR			Q86UT5	NHRF4_HUMAN	RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF4;          Short=NHERF-4; AltName: Full=PDZ domain-containing protein 3; AltName: Full=PDZ domain-containing protein 2; AltName: Full=Intestinal and kidney-enriched PDZ protein; AltName: Full=Sodium-hydrogen exchanger regulatory factor 4;	364	PDZ 3.				cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)	1	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		ACCCGGGACTGCCAGCCAAGA	0.642													13	55					1.3612e-06	1.58371e-06	1	0	T	119059095	T	T	119059095	2	4	186	1	0	0	0	0	0	0	0	1	11756	1306	46	4		4	PDZD3	11	119059095	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	29923602	119059095	15947421	113	34587											
TMEM225	338661	broad.mit.edu	37	chr11	123753941	123753941	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggcattgcagtgcattcTggtaatgaaatatcttcgat	11	13	10	7	2	2	1	0	1	2	0	3	3	2	1	0	2	2	4	0	2	3	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr11:123753941T>C	uc001pzi.2	-	4	790	c.582A>G	c.(580-582)CCA>CCG	p.P194P		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	194						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						CAGTGCATTCTGGTAATGAAA	0.428													23	73					0	0	0	0	C	123753941	C	C	123753941	2	2	186	1	0	0	0	0	0	0	0	1	16213	1567	55	5		5	TMEM225	11	123753941	Silent	SNP	T	TCGA-CV-5978-01A-11D-1683-08	4694846	123753941	11252575	114	34588											
CD163	9332	broad.mit.edu	37	chr12	7649408	7649408	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttggtttggttttaacttaCcagaacatgtcacgccagca	10	14	8	9	1	1	1	1	0	0	1	1	1	1	1	2	2	4	3	2	2	3	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:7649408C>G	uc001qsz.3	-	5	1227	c.1099_splice	c.e5+1	p.D367_splice	CD163_uc001qta.3_Splice_Site_p.D367_splice|CD163_uc009zfw.2_Splice_Site_p.D367_splice	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a						acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TTTTAACTTACCAGAACATGT	0.343													9	73					0	0	0	0	G	7649408	G	G	7649408	5	3	186	1	0	0	0	0	0	0	1	0	2982	521	18	4	2418	4	CD163	12	7649408	Splice_Site	SNP	C	TCGA-CV-5978-01A-11D-1683-08		7649408	126202487	115	34589											
PRH1	5554	broad.mit.edu	37	chr12	11034867	11034867	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccctgtggaggtccttgTgggcggcccccttggggagg	2	9	18	12	1	0	0	0	0	0	0	1	2	1	2	5	7	1	0	5	7	0	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:11034867T>A	uc001qzc.2	-	8	1056	c.468A>T	c.(466-468)CCA>CCT	p.P156P	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_RNA|PRB4_uc001qzf.1_Intron	NM_006250	NP_006241	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1	156						extracellular space	protein binding				0				BRCA - Breast invasive adenocarcinoma(232;0.245)		GAGGTCCTTGTGGGCGGCCCC	0.572													32	147					0	0	0	0	A	11034867	A	A	11034867	2	1	186	1	0	0	0	0	0	0	0	1	12544	1683	59	5		5	PRH1	12	11034867	Silent	SNP	T	TCGA-CV-5978-01A-11D-1683-08	3385459	11034867	122817028	116	34590											
ATF7IP	55729	broad.mit.edu	37	chr12	14613818	14613818	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccaaacaacgttccttctGtgcccagtcctagtattcaa	12	11	5	13	1	2	0	1	0	1	0	4	0	4	0	4	0	4	2	4	0	6	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:14613818G>A	uc001rbw.2	+	9	2706	c.2548G>A	c.(2548-2550)GTG>ATG	p.V850M	ATF7IP_uc010shs.1_3'UTR|ATF7IP_uc001rbu.2_Missense_Mutation_p.V850M|ATF7IP_uc001rbv.1_Missense_Mutation_p.V849M|ATF7IP_uc001rbx.2_Missense_Mutation_p.V849M|ATF7IP_uc010sht.1_3'UTR|ATF7IP_uc001rby.3_Missense_Mutation_p.V850M|ATF7IP_uc001rca.2_Missense_Mutation_p.V850M	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	850					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						CGTTCCTTCTGTGCCCAGTCC	0.478													31	113					0	0	0	0	A	14613818	A	A	14613818	3	1	186	1	0	0	0	0	1	0	0	0	1089	1377	48	4	2578	4	ATF7IP	12	14613818	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	3578951	14613818	119238077	117	34591											
PLEKHA5	54477	broad.mit.edu	37	chr12	19475473	19475473	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acacgcttgagcaagctttgCtatcagccagccaagagata	13	8	9	11	1	1	2	1	1	0	1	1	3	1	2	2	0	5	4	2	0	4	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:19475473C>T	uc001reb.2	+	15	2097	c.2011C>T	c.(2011-2013)CTA>TTA	p.L671L	PLEKHA5_uc010sie.1_Silent_p.L774L|PLEKHA5_uc001rea.2_Silent_p.L729L|PLEKHA5_uc009zin.2_Silent_p.L429L|PLEKHA5_uc010sif.1_Silent_p.L602L|PLEKHA5_uc010sig.1_Silent_p.L590L|PLEKHA5_uc010sih.1_Silent_p.L563L|PLEKHA5_uc001rec.1_Silent_p.L417L|PLEKHA5_uc009zio.2_5'UTR	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	671							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GCAAGCTTTGCTATCAGCCAG	0.363													28	47					0	0	0	0	T	19475473	T	T	19475473	2	4	186	1	0	0	0	0	0	0	0	1	12114	796	28	4		4	PLEKHA5	12	19475473	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	4861655	19475473	114376422	118	34592											
SYT10	341359	broad.mit.edu	37	chr12	33532866	33532866	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcagcatccagtcctgttctGcacactcctatgacctcatt	8	13	5	15	0	3	1	2	1	1	0	6	1	6	1	4	0	2	3	4	0	1	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:33532866G>T	uc001rll.1	-	6	1698	c.1401C>A	c.(1399-1401)TGC>TGA	p.C467*	SYT10_uc009zju.1_Nonsense_Mutation_p.C277*	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	467	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GTCCTGTTCTGCACACTCCTA	0.453													21	98					1.96292e-10	2.4741e-10	1	0	T	33532866	T	T	33532866	4	4	186	1	0	0	0	0	0	1	0	0	15532	1311	46	4	178	4	SYT10	12	33532866	Nonsense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	14057393	33532866	100319029	119	34593											
LRRK2	120892	broad.mit.edu	37	chr12	40734242	40734242	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagaatggggataaaaacatCagagggcacaccaggtaggt	16	6	13	6	0	1	2	1	0	0	2	1	3	1	3	1	5	1	2	1	5	6	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:40734242C>G	uc001rmg.3	+	41	6216	c.6095C>G	c.(6094-6096)TCA>TGA	p.S2032*	LRRK2_uc009zjw.2_Nonsense_Mutation_p.S870*|LRRK2_uc001rmi.2_Nonsense_Mutation_p.S865*	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2032	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ATAAAAACATCAGAGGGCACA	0.443													17	72					0	0	0	0	G	40734242	G	G	40734242	4	3	186	1	0	0	0	0	0	1	0	0	9083	838	29	2	6257	2	LRRK2	12	40734242	Nonsense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	7201376	40734242	93117653	120	34594											
HOXC6	3223	broad.mit.edu	37	chr12	54422697	54422697	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggatgcagcgaatgaattCgcacagtggtgagttttaca	11	11	12	7	2	0	2	0	2	0	0	1	4	0	3	0	2	3	3	0	2	3	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:54422697C>T	uc001sev.2	+	1	504	c.392C>T	c.(391-393)TCG>TTG	p.S131L	HOXC6_uc001ses.2_Missense_Mutation_p.S49L|HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron	NM_004503	NP_004494	P09630	HXC6_HUMAN	homeobox C6 isoform 1	131					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|upper_aerodigestive_tract(1)	3						CGAATGAATTCGCACAGTGGT	0.473													4	79					0	0	0	0	T	54422697	T	T	54422697	3	4	186	1	0	0	0	0	1	0	0	0	7354	893	31	1	394	1	HOXC6	12	54422697	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	13688455	54422697	79429198	121	34595											
NXPH4	11247	broad.mit.edu	37	chr12	57619381	57619381	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtcgcaggtgtgcttcaccGagcacacgcagagccaggcc	8	5	13	15	4	1	1	1	0	0	1	2	2	1	1	3	2	3	4	3	2	0	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:57619381G>A	uc010srf.1	+	2	953	c.778G>A	c.(778-780)GAG>AAG	p.E260K	NXPH4_uc009zpj.2_Missense_Mutation_p.E66K	NM_007224	NP_009155	O95158	NXPH4_HUMAN	neurexophilin 4 precursor	260	V (Cys-rich).				neuropeptide signaling pathway	extracellular region					0						GTGCTTCACCGAGCACACGCA	0.567													16	24					0	0	0	0	A	57619381	A	A	57619381	3	1	186	1	0	0	0	0	1	0	0	0	10847	1059	37	1	784	1	NXPH4	12	57619381	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	3196684	57619381	76232514	122	34596											
ALX1	8092	broad.mit.edu	37	chr12	85680630	85680630	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taatttttattaaataattaGgtttggtttcaaaatcgaag	15	18	6	2	1	1	0	1	0	0	0	2	1	1	0	0	2	0	2	0	2	9	9			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:85680630G>C	uc001tae.3	+	3	536	c.532_splice	c.e3-1	p.V178_splice		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1						brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		taaataattaGGTTTGGTTTC	0.313													4	13					0	0	0	0	C	85680630	C	C	85680630	5	2	186	1	0	0	0	0	0	0	1	0	556	1014	35	4	541	4	ALX1	12	85680630	Splice_Site	SNP	G	TCGA-CV-5978-01A-11D-1683-08	28061249	85680630	48171265	123	34597											
KIAA1033	23325	broad.mit.edu	37	chr12	105515902	105515902	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taattttcctcaaggttactGaaatctgtccatcacaatcc	12	14	4	11	0	3	1	2	1	1	0	6	1	6	1	3	1	1	1	3	1	5	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:105515902G>A	uc001tld.2	+	10	759	c.672G>A	c.(670-672)CTG>CTA	p.L224L	KIAA1033_uc010swr.1_Silent_p.L224L|KIAA1033_uc010sws.1_Silent_p.L36L	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	224					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						CAAGGTTACTGAAATCTGTCC	0.274													7	64					0	0	0	0	A	105515902	A	A	105515902	2	1	186	1	0	0	0	0	0	0	0	1	8245	1277	45	2		2	KIAA1033	12	105515902	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	19835272	105515902	28335993	124	34598											
ISCU	23479	broad.mit.edu	37	chr12	108959132	108959132	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaggggaagattgtggatgcTaggtttaaaacatttggctg	12	12	14	3	0	0	1	0	0	0	1	0	3	0	3	0	5	2	3	0	5	5	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr12:108959132T>C	uc010sxc.1	+	3	369	c.264T>C	c.(262-264)GCT>GCC	p.A88A	ISCU_uc010sxa.1_Silent_p.A88A|ISCU_uc010sxb.1_Silent_p.A88A|ISCU_uc001tnc.3_Silent_p.A63A|ISCU_uc009zuy.2_Silent_p.A63A|ISCU_uc010sxd.1_Silent_p.A88A	NM_213595	NP_998760	Q9H1K1	ISCU_HUMAN	iron-sulfur cluster assembly enzyme isoform	88					iron-sulfur cluster assembly|nitrogen fixation	cytosol|mitochondrion|nucleus	iron ion binding|iron-sulfur cluster binding|protein complex scaffold				0						TTGTGGATGCTAGGTTTAAAA	0.473													5	48					0	0	0	0	C	108959132	C	C	108959132	2	2	186	1	0	0	0	0	0	0	0	1	7891	1509	53	5		5	ISCU	12	108959132	Silent	SNP	T	TCGA-CV-5978-01A-11D-1683-08	3443230	108959132	24892763	125	34599											
ERCC5	2073	broad.mit.edu	37	chr13	103520608	103520608	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaacctctcctaaaattctcGtaaggtcttttatttcttta	10	18	4	9	1	4	0	0	0	4	0	6	1	4	0	2	1	1	1	2	1	6	8			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr13:103520608G>C	uc001vpw.2	+	12	3121	c.2678_splice	c.e12+1	p.S893_splice	ERCC5_uc001vpu.1_Splice_Site_p.S1347_splice|ERCC5_uc010tjc.1_Splice_Site|ERCC5_uc010tjd.1_Splice_Site_p.S725_splice	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein						negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TAAAATTCTCGTAAGGTCTTT	0.373			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				3	44					0	0	0	0	C	103520608	C	C	103520608	5	2	186	1	0	0	0	0	0	0	1	0	5240	1159	40	3	2725	3	ERCC5	13	103520608	Splice_Site	SNP	G	TCGA-CV-5978-01A-11D-1683-08		103520608	11649270	126	34600											
MYO16	23026	broad.mit.edu	37	chr13	109779811	109779811	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggaaacagcccccgcccaagCcaaagagggaccccaacacc	14	0	9	18	1	0	1	0	0	0	1	0	3	0	3	7	2	4	0	7	2	4	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr13:109779811C>A	uc001vqt.1	+	31	4024	c.3898C>A	c.(3898-3900)CCA>ACA	p.P1300T	MYO16_uc010agk.1_Missense_Mutation_p.P1322T|MYO16_uc010tjh.1_Missense_Mutation_p.P812T	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1300					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCCGCCCAAGCCAAAGAGGGA	0.657													10	13					2.17888e-05	2.44115e-05	1	0	A	109779811	A	A	109779811	3	1	186	1	0	0	0	0	1	0	0	0	10117	739	26	4	4016	4	MYO16	13	109779811	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	6259203	109779811	5390067	127	34601											
G2E3	55632	broad.mit.edu	37	chr14	31071100	31071100	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggtattatctacaattcaGgtaatttttttgtaattttg	10	20	8	3	0	2	0	1	0	1	0	2	0	2	0	0	3	1	3	0	3	6	11	rs60676717		TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr14:31071100G>T	uc001wqk.2	+	9	1031	c.877G>T	c.(877-879)GGA>TGA	p.G293*	G2E3_uc010tpe.1_Nonsense_Mutation_p.G208*|G2E3_uc010tpf.1_Nonsense_Mutation_p.G247*	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	293					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						CTACAATTCAGGTAATTTTTT	0.318													30	30					3.17567e-06	3.65958e-06	1	0	T	31071100	T	T	31071100	4	4	186	1	0	0	0	0	0	1	0	0	6174	1014	35	4	907	4	G2E3	14	31071100	Nonsense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08		31071100	76278440	128	34602											
DACT1	51339	broad.mit.edu	37	chr14	59105250	59105250	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggaggagaacatcttgctGctaagaaagcaattggtagg	13	10	13	5	0	1	2	0	0	1	2	1	4	1	3	0	4	4	4	0	4	5	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr14:59105250G>T	uc001xdw.2	+	1	494	c.330G>T	c.(328-330)CTG>CTT	p.L110L	DACT1_uc010trv.1_Intron|DACT1_uc001xdx.2_Silent_p.L110L|DACT1_uc010trw.1_5'Flank	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	110	Potential.				multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						ACATCTTGCTGCTAAGAAAGC	0.562													5	10					5.9392e-07	6.97712e-07	1	0	T	59105250	T	T	59105250	2	4	186	1	0	0	0	0	0	0	0	1	4239	1306	46	4		4	DACT1	14	59105250	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	28034150	59105250	48244290	129	34603											
GALNTL1	57452	broad.mit.edu	37	chr14	69808451	69808451	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaactgcaagtccttccgctGgtacctggagaacgtctacc	9	9	10	13	2	1	1	0	0	1	1	3	3	3	1	4	2	5	3	4	2	5	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr14:69808451G>A	uc010aqu.1	+	12	1334	c.1241G>A	c.(1240-1242)TGG>TAG	p.W414*	GALNTL1_uc001xla.1_Nonsense_Mutation_p.W414*|GALNTL1_uc001xlb.1_Nonsense_Mutation_p.W414*	NM_020692	NP_065743	Q8N428	GLTL1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	414	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)		TCCTTCCGCTGGTACCTGGAG	0.612													8	12					0	0	0	0	A	69808451	A	A	69808451	4	1	186	1	0	0	0	0	0	1	0	0	6256	1357	47	4	1287	4	GALNTL1	14	69808451	Nonsense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	10703201	69808451	37541089	130	34604											
SLC8A3	6547	broad.mit.edu	37	chr14	70633619	70633619	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctaggacagcccgaggcaaGggaagactgttgaatattgc	12	7	14	8	1	0	2	0	1	0	1	0	5	0	4	1	3	2	3	1	3	5	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr14:70633619G>T	uc001xly.2	-	2	2275	c.1521C>A	c.(1519-1521)CCC>CCA	p.P507P	SLC8A3_uc001xlw.2_Silent_p.P507P|SLC8A3_uc001xlx.2_Silent_p.P507P|SLC8A3_uc001xlz.2_Silent_p.P507P|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	507	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CCCGAGGCAAGGGAAGACTGT	0.498													29	34					4.87955e-14	6.74773e-14	1	0	T	70633619	T	T	70633619	2	4	186	1	0	0	0	0	0	0	0	1	14772	987	35	4		4	SLC8A3	14	70633619	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	825168	70633619	36715921	131	34605											
ATG2B	55102	broad.mit.edu	37	chr14	96797952	96797952	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggccttgattcatccacTgaaacagatctagatgggag	12	10	10	9	0	3	4	2	2	1	2	4	5	4	5	2	2	1	0	2	2	2	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr14:96797952T>C	uc001yfi.2	-	11	1856	c.1491A>G	c.(1489-1491)TCA>TCG	p.S497S		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	497										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		ATTCATCCACTGAAACAGATC	0.308													11	50					0	0	0	0	C	96797952	C	C	96797952	2	2	186	1	0	0	0	0	0	0	0	1	1096	1567	55	5		5	ATG2B	14	96797952	Silent	SNP	T	TCGA-CV-5978-01A-11D-1683-08	26164333	96797952	10551588	132	34606											
C14orf73	91828	broad.mit.edu	37	chr14	103573762	103573762	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcccctctgtccccagcCgctcttcagggttgtgtgca	4	10	10	17	1	3	0	1	0	2	0	4	0	4	0	6	1	3	3	6	1	0	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr14:103573762C>T	uc001ymk.2	+	8	1659	c.1583C>T	c.(1582-1584)CCG>CTG	p.P528L		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	528											0		Melanoma(154;0.155)	Epithelial(46;0.221)			TGTCCCCAGCCGCTCTTCAGG	0.632													21	24					0	0	0	0	T	103573762	T	T	103573762	3	4	186	1	0	0	0	0	1	0	0	0	1785	666	23	1	1613	1	C14orf73	14	103573762	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	6775810	103573762	3775778	133	34607											
ARHGAP11A	9824	broad.mit.edu	37	chr15	32926132	32926132	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttttaattccacttcttctAgagtggaatcaggaaaagca	13	14	7	7	0	3	1	1	0	2	1	4	3	4	3	1	2	1	1	1	2	5	7			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr15:32926132A>G	uc001zgy.1	+	10	1958	c.1236_splice	c.e10-2	p.R412_splice	ARHGAP11A_uc010ubw.1_Splice_Site_p.R223_splice|ARHGAP11A_uc001zgw.2_Splice_Site_p.R412_splice|ARHGAP11A_uc001zgx.2_Splice_Site_p.R384_splice|ARHGAP11A_uc010ubx.1_Splice_Site_p.R223_splice	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		CACTTCTTCTAGAGTGGAATC	0.333													6	8					0	0	0	0	G	32926132	G	G	32926132	5	3	186	1	0	0	0	0	0	0	1	0	863	434	15	5	1272	5	ARHGAP11A	15	32926132	Splice_Site	SNP	A	TCGA-CV-5978-01A-11D-1683-08		32926132	69605260	134	34608											
ZWILCH	55055	broad.mit.edu	37	chr15	66821212	66821212	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttgaagcatgacactgctgCagtcgatcgttccgtcaagc	9	10	10	12	3	1	2	1	2	0	0	4	3	2	2	1	0	4	4	1	0	2	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr15:66821212C>T	uc002aqb.2	+	11	1238	c.992C>T	c.(991-993)GCA>GTA	p.A331V	ZWILCH_uc010bhu.1_Missense_Mutation_p.A217V|ZWILCH_uc002aqa.2_Missense_Mutation_p.A217V|ZWILCH_uc010bhv.2_Missense_Mutation_p.A217V	NM_017975	NP_060445	Q9H900	ZWILC_HUMAN	Zwilch	331					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			ovary(1)	1						GACACTGCTGCAGTCGATCGT	0.408													7	37					0	0	0	0	T	66821212	T	T	66821212	3	4	186	1	0	0	0	0	1	0	0	0	18315	710	25	4	1034	4	ZWILCH	15	66821212	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	33895080	66821212	35710180	135	34609											
C15orf59	388135	broad.mit.edu	37	chr15	74032449	74032449	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggggctggggagggcttgtGggggcctgcatgggcctctg	2	8	23	8	0	1	0	0	0	1	0	1	1	1	1	2	8	1	3	2	8	0	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr15:74032449G>A	uc002avy.2	-	2	1036	c.691C>T	c.(691-693)CAC>TAC	p.H231Y		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	231										pancreas(1)	1						GAGGGCTTGTGGGGGCCTGCA	0.498													3	47					0	0	0	0	A	74032449	A	A	74032449	3	1	186	1	0	0	0	0	1	0	0	0	1813	1348	47	4	194	4	C15orf59	15	74032449	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	7211237	74032449	28498943	136	34610											
ADAMTS7	11173	broad.mit.edu	37	chr15	79080663	79080663	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggagacatgatgaaaggtCgtttcccaacgggctcacag	11	8	13	9	2	1	3	1	2	0	1	3	4	2	3	1	3	1	2	1	3	2	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr15:79080663C>T	uc002bej.3	-	8	1443	c.1232G>A	c.(1231-1233)CGA>CAA	p.R411Q	ADAMTS7_uc010und.1_Intron|ADAMTS7_uc002bek.1_Missense_Mutation_p.R411Q	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	411	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						GATGAAAGGTCGTTTCCCAAC	0.612													39	79					0	0	0	0	T	79080663	T	T	79080663	3	4	186	1	0	0	0	0	1	0	0	0	271	884	31	1	3896	1	ADAMTS7	15	79080663	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	5048214	79080663	23450729	137	34611											
NTRK3	4916	broad.mit.edu	37	chr15	88472648	88472648	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtccatccacaaggatcattGcatctggcccatgggccctg	8	9	10	14	0	2	0	1	0	1	0	4	1	4	1	4	3	1	1	4	3	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr15:88472648G>A	uc002bme.1	-	16	2069	c.1907C>T	c.(1906-1908)GCA>GTA	p.A636V	NTRK3_uc002bmh.2_Missense_Mutation_p.A628V|NTRK3_uc002bmf.1_Missense_Mutation_p.A636V|NTRK3_uc010upl.1_Missense_Mutation_p.A538V|NTRK3_uc010bnh.1_Missense_Mutation_p.A628V	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	636	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			AAGGATCATTGCATCTGGCCC	0.522			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			6	29					0	0	0	0	A	88472648	A	A	88472648	3	1	186	1	0	0	0	0	1	0	0	0	10762	1319	46	4	628	4	NTRK3	15	88472648	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	9391985	88472648	14058744	138	34612											
CRTC3	64784	broad.mit.edu	37	chr15	91185222	91185222	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgctggcaggcctgcctgaGgtcagcctgaacgtggacac	7	6	15	13	2	1	2	1	2	0	0	1	3	1	3	3	4	3	2	3	4	1	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr15:91185222G>T	uc002bpp.2	+	15	1816	c.1710G>T	c.(1708-1710)GAG>GAT	p.E570D	CRTC3_uc002bpo.2_Missense_Mutation_p.E569D	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	570					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			GCCTGCCTGAGGTCAGCCTGA	0.562			T	MAML2	salivary gland mucoepidermoid								7	59					1.26484e-09	1.5697e-09	1	0	T	91185222	T	T	91185222	3	4	186	1	0	0	0	0	1	0	0	0	3916	991	35	4	1768	4	CRTC3	15	91185222	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	2712574	91185222	11346170	139	34613											
ZSCAN10	84891	broad.mit.edu	37	chr16	3139838	3139838	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccaccaggtgctcgctgcGccggaaggccttgccgcagt	5	6	15	15	4	0	0	0	0	0	0	1	1	0	1	5	4	3	3	5	4	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr16:3139838G>A	uc002ctv.1	-	5	1520	c.1432C>T	c.(1432-1434)CGC>TGC	p.R478C	ZSCAN10_uc002cty.1_Missense_Mutation_p.R139C|ZSCAN10_uc002ctw.1_Missense_Mutation_p.R396C|ZSCAN10_uc002ctx.1_Missense_Mutation_p.R406C	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	478	C2H2-type 6.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TGCTCGCTGCGCCGGAAGGCC	0.731													3	9					0	0	0	0	A	3139838	A	A	3139838	3	1	186	1	0	0	0	0	1	0	0	0	18294	1087	38	1	749	1	ZSCAN10	16	3139838	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08		3139838	87214915	140	34614											
ERCC4	2072	broad.mit.edu	37	chr16	14024633	14024633	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agactaaatccttagttcagGatttgaagatattacgaact	15	13	7	6	1	1	3	1	1	0	2	2	5	2	4	1	1	2	1	1	1	7	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr16:14024633G>A	uc002dce.2	+	5	868	c.859G>A	c.(859-861)GAT>AAT	p.D287N	ERCC4_uc010bva.2_Missense_Mutation_p.D287N	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	287	Leucine-zipper 2.				double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						CTTAGTTCAGGATTTGAAGAT	0.373			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				3	35					0	0	0	0	A	14024633	A	A	14024633	3	1	186	1	0	0	0	0	1	0	0	0	5239	1174	41	2	877	2	ERCC4	16	14024633	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	10884795	14024633	76330120	141	34615											
CPNE2	221184	broad.mit.edu	37	chr16	57180102	57180102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccatgtccatcatcatcGtgggcgtgggcaatgcggac	7	9	13	12	3	2	0	2	0	0	0	4	1	3	1	2	3	2	1	2	3	1	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr16:57180102G>A	uc002eks.1	+	15	1637	c.1408G>A	c.(1408-1410)GTG>ATG	p.V470M	CPNE2_uc010cct.1_Missense_Mutation_p.V496M|CPNE2_uc010ccu.1_Missense_Mutation_p.V470M|CPNE2_uc002ekt.1_Missense_Mutation_p.V166M	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	470	VWFA.									central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				CATCATCATCGTGGGCGTGGG	0.617													4	7					0	0	0	0	A	57180102	A	A	57180102	3	1	186	1	0	0	0	0	1	0	0	0	3827	1145	40	1	1462	1	CPNE2	16	57180102	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	43155469	57180102	33174651	142	34616											
CDH8	1006	broad.mit.edu	37	chr16	61891110	61891110	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccataaactgggtcatcagCgtcggtcgcagtgacgttag	9	10	12	10	4	2	1	2	1	0	0	5	1	3	1	1	2	2	2	1	2	3	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr16:61891110C>A	uc002eog.1	-	4	832	c.580G>T	c.(580-582)GCT>TCT	p.A194S	CDH8_uc002eoh.2_5'UTR	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	194	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GGGTCATCAGCGTCGGTCGCA	0.383													18	52					7.07596e-05	7.8191e-05	1	0	A	61891110	A	A	61891110	3	1	186	1	0	0	0	0	1	0	0	0	3131	768	27	3	1855	3	CDH8	16	61891110	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	4711008	61891110	28463643	143	34617											
CMTM3	123920	broad.mit.edu	37	chr16	66642247	66642247	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttttatctgctatgtggcGtcctcagcatctgccttcct	5	16	7	13	1	3	0	1	0	2	0	5	0	5	0	3	1	3	2	3	1	2	4	rs149684359		TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr16:66642247G>A	uc002epu.2	+	3	442	c.183G>A	c.(181-183)GCG>GCA	p.A61A	CMTM3_uc002epv.2_Silent_p.A61A|CMTM3_uc002epw.2_Silent_p.A61A|CMTM3_uc002epx.2_Silent_p.A61A|CMTM3_uc002epy.2_RNA	NM_001048251	NP_001041716	Q96MX0	CKLF3_HUMAN	chemokine-like factor superfamily 3	61	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0671)|Epithelial(162;0.164)		GCTATGTGGCGTCCTCAGCAT	0.527											OREG0023859	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	119					0	0	0	0	A	66642247	A	A	66642247	2	1	186	1	0	0	0	0	0	0	0	1	3599	1132	40	1		1	CMTM3	16	66642247	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	4751137	66642247	23712506	144	34618											
TP53	7157	broad.mit.edu	37	chr17	7578416	7578416	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtgggggcagcgcctcacaaCctccgtcatgtgctgtgact	6	9	13	13	2	2	1	2	1	0	0	3	1	3	1	3	2	3	2	3	2	1	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr17:7578416C>A	uc002gim.2	-	5	708	c.514G>T	c.(514-516)GTT>TTT	p.V172F	TP53_uc002gig.1_Missense_Mutation_p.V172F|TP53_uc002gih.2_Missense_Mutation_p.V172F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V40F|TP53_uc010cng.1_Missense_Mutation_p.V40F|TP53_uc002gii.1_Missense_Mutation_p.V40F|TP53_uc010cnh.1_Missense_Mutation_p.V172F|TP53_uc010cni.1_Missense_Mutation_p.V172F|TP53_uc002gij.2_Missense_Mutation_p.V172F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V79F|TP53_uc002gio.2_Missense_Mutation_p.V40F|TP53_uc010vug.1_Missense_Mutation_p.V133F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	172	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> A (in sporadic cancers; somatic mutation).|V -> I (in sporadic cancers; somatic mutation).|V -> F (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V172F(10)|p.V172D(8)|p.V172I(7)|p.0?(7)|p.V172V(4)|p.V172A(4)|p.V172fs*2(3)|p.V172G(3)|p.V173fs*59(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.P151_V173del23(1)|p.S149fs*72(1)|p.E171fs*61(1)|p.V172_E180delVVRRCPHHE(1)|p.T170fs*2(1)|p.E171fs*1(1)|p.T170fs*8(1)|p.V172fs*9(1)|p.H168fs*69(1)|p.E171_H179delEVVRRCPHH(1)|p.E171_V172delEV(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGCCTCACAACCTCCGTCATG	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	32					7.01153e-11	8.93048e-11	1	0	A	7578416	A	A	7578416	3	1	186	1	0	0	0	0	1	0	0	0	16448	507	18	4	784	4	TP53	17	7578416	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08		7578416	73616794	145	34619											
DHRS7C	201140	broad.mit.edu	37	chr17	9674889	9674889	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccgggaagaaggtgcggacGtacacggcggccttggggat	8	6	18	9	5	0	1	0	0	0	1	1	4	1	4	2	7	2	1	2	7	3	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr17:9674889G>A	uc010vvb.1	-	6	855	c.855C>T	c.(853-855)TAC>TAT	p.Y285Y	DHRS7C_uc010cof.2_Silent_p.Y284Y	NM_001105571	NP_001099041	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	285						extracellular region	binding|oxidoreductase activity				0						AGGTGCGGACGTACACGGCGG	0.612													4	14					0	0	0	0	A	9674889	A	A	9674889	2	1	186	1	0	0	0	0	0	0	0	1	4519	1140	40	1		1	DHRS7C	17	9674889	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	2096473	9674889	71520321	146	34620											
ZNF286B	729288	broad.mit.edu	37	chr17	18565761	18565761	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attcattacattcataaggcCtcactccagtatgaatcaac	14	12	4	11	0	4	1	4	1	0	0	5	1	5	1	2	1	2	1	2	1	5	5	rs150903875	by1000genomes	TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr17:18565761C>T	uc010vyd.1	-	5	1309	c.1058G>A	c.(1057-1059)AGG>AAG	p.R353K		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCATAAGGCCTCACTCCAGT	0.358													3	19					0	0	0	0	T	18565761	T	T	18565761	3	4	186	1	0	0	0	0	1	0	0	0	17891	681	24	4	514	4	ZNF286B	17	18565761	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	8890872	18565761	62629449	147	34621											
MYCBPAP	84073	broad.mit.edu	37	chr17	48602314	48602314	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgatgggggtcttgacccCggagcgcacaccatcacctg	7	7	13	14	2	2	2	1	2	1	0	2	3	2	3	4	3	1	2	4	3	0	1	rs140934764	byFrequency	TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr17:48602314C>T	uc010wmr.1	+	13	2003	c.1841C>T	c.(1840-1842)CCG>CTG	p.P614L	MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	577					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GTCTTGACCCCGGAGCGCACA	0.627													25	62					0	0	0	0	T	48602314	T	T	48602314	3	4	186	1	0	0	0	0	1	0	0	0	10072	652	23	1	1891	1	MYCBPAP	17	48602314	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	30036553	48602314	32592896	148	34622											
MPPE1	65258	broad.mit.edu	37	chr18	11893517	11893517	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatcccccaggatgaagaCgacttccggctgcagcaacc	11	6	10	14	2	0	2	0	1	0	1	2	5	2	3	4	2	3	3	4	2	3	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr18:11893517C>T	uc002kqf.2	-	4	981	c.340G>A	c.(340-342)GTC>ATC	p.V114I	MPPE1_uc002kqn.2_Missense_Mutation_p.V114I|MPPE1_uc002kqg.2_RNA|MPPE1_uc002kqh.2_RNA|MPPE1_uc002kqi.2_RNA|MPPE1_uc002kqj.2_Missense_Mutation_p.V114I|MPPE1_uc002kqk.2_Missense_Mutation_p.V114I|MPPE1_uc002kql.2_Missense_Mutation_p.V114I|MPPE1_uc002kqm.2_Missense_Mutation_p.V114I|MPPE1_uc010dla.1_Missense_Mutation_p.V114I	NM_023075	NP_075563	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1 precursor	114					ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0						AGGATGAAGACGACTTCCGGC	0.532													8	45					0	0	0	0	T	11893517	T	T	11893517	3	4	186	1	0	0	0	0	1	0	0	0	9793	536	19	1	882	1	MPPE1	18	11893517	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08		11893517	66183731	149	34623											
ZNF519	162655	broad.mit.edu	37	chr18	14106206	14106206	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctcctttcacagttaaatgTttgttatgactagttgtcaa	10	18	6	7	0	3	1	2	1	1	0	4	1	3	1	1	0	0	4	1	0	5	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr18:14106206T>C	uc002kst.1	-	3	486	c.333A>G	c.(331-333)AAA>AAG	p.K111K	ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	111					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGTTAAATGTTTGTTATGAC	0.333													12	51					0	0	0	0	C	14106206	C	C	14106206	2	2	186	1	0	0	0	0	0	0	0	1	18031	1722	60	5		5	ZNF519	18	14106206	Silent	SNP	T	TCGA-CV-5978-01A-11D-1683-08	2212689	14106206	63971042	150	34624											
ASXL3	80816	broad.mit.edu	37	chr18	31322978	31322978	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggagccaggaccctcgcaGatatcaaggcccgggcccaa	11	3	12	15	2	1	1	1	0	0	1	2	3	1	3	4	4	1	1	4	4	3	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr18:31322978G>T	uc010dmg.1	+	12	3221	c.3166G>T	c.(3166-3168)GAT>TAT	p.D1056Y	ASXL3_uc002kxq.2_Missense_Mutation_p.D763Y	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1056	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GACCCTCGCAGATATCAAGGC	0.587													4	9					1.23904e-05	1.39464e-05	1	0	T	31322978	T	T	31322978	3	4	186	1	0	0	0	0	1	0	0	0	1070	942	33	2	3212	2	ASXL3	18	31322978	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	17216772	31322978	46754270	151	34625											
RIT2	6014	broad.mit.edu	37	chr18	40323626	40323626	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagaatctgagggctgcagaGgtctcaaaaaaaccacaatt	16	7	9	9	0	2	3	1	1	2	2	3	3	2	3	1	2	2	2	1	2	5	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr18:40323626G>T	uc002lav.2	-	5	659	c.486C>A	c.(484-486)ACC>ACA	p.T162T	RIT2_uc010dnf.2_3'UTR	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	162					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						GGGCTGCAGAGGTCTCAAAAA	0.378													26	44					4.47668e-21	6.48716e-21	1	0	T	40323626	T	T	40323626	2	4	186	1	0	0	0	0	0	0	0	1	13452	987	35	4		4	RIT2	18	40323626	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	9000648	40323626	37753622	152	34626											
ST8SIA5	29906	broad.mit.edu	37	chr18	44266168	44266168	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcggcgctgttgatctcccTcccgcagcggctgttcttca	3	12	11	15	4	3	1	1	1	2	0	6	1	4	1	2	2	1	5	2	2	0	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr18:44266168T>A	uc002lcj.1	-	5	1106	c.538A>T	c.(538-540)AGG>TGG	p.R180W	ST8SIA5_uc002lci.1_Missense_Mutation_p.R27W|ST8SIA5_uc010xcy.1_Missense_Mutation_p.R216W|ST8SIA5_uc010xcz.1_Missense_Mutation_p.R149W	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	180	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						TTGATCTCCCTCCCGCAGCGG	0.587													5	48					0	0	0	0	A	44266168	A	A	44266168	3	1	186	1	0	0	0	0	1	0	0	0	15301	1550	54	5	604	5	ST8SIA5	18	44266168	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	3942542	44266168	33811080	153	34627											
HCN2	610	broad.mit.edu	37	chr19	608035	608035	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacatgctgtgcatcgggtaCggccggcaggcgcccgagag	7	5	16	13	5	0	1	0	0	0	1	1	2	0	1	2	4	3	4	2	4	1	1	rs145436026	byFrequency	TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:608035C>T	uc002lpe.2	+	4	1343	c.1290C>T	c.(1288-1290)TAC>TAT	p.Y430Y		NM_001194	NP_001185	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic	430					cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCATCGGGTACGGCCGGCAGG	0.617													7	50					0	0	0	0	T	608035	T	T	608035	2	4	186	1	0	0	0	0	0	0	0	1	7036	547	19	1		1	HCN2	19	608035	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08		608035	58520948	154	34628											
C3	718	broad.mit.edu	37	chr19	6709693	6709693	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccttgggtcactggcccttAccttactctgcgtcagtttg	4	14	10	13	1	3	0	2	0	1	0	3	0	3	0	3	2	3	1	3	2	2	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:6709693A>T	uc002mfm.2	-	14	1907	c.1845_splice	c.e14+1	p.K615_splice		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor						complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACTGGCCCTTACCTTACTCTG	0.627													16	168					0	0	0	0	T	6709693	T	T	6709693	5	4	186	1	0	0	0	0	0	0	1	0	2214	405	14	5	3256	5	C3	19	6709693	Splice_Site	SNP	A	TCGA-CV-5978-01A-11D-1683-08	6101658	6709693	52419290	155	34629											
MUC16	94025	broad.mit.edu	37	chr19	9059076	9059076	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacagggacaggagaggagTggctactcccagatggtgtg	10	7	17	7	0	0	3	0	1	0	2	1	6	1	5	1	5	1	1	1	5	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:9059076T>C	uc002mkp.2	-	3	28574	c.28370A>G	c.(28369-28371)CAC>CGC	p.H9457R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9459	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGAGAGGAGTGGCTACTCCC	0.498													20	79					0	0	0	0	C	9059076	C	C	9059076	3	2	186	1	0	0	0	0	1	0	0	0	10026	1696	59	5	15481	5	MUC16	19	9059076	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	2349383	9059076	50069907	156	34630											
MUC16	94025	broad.mit.edu	37	chr19	9062974	9062974	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttctgctagaggaggtgaCttctgtcctggagacttcag	7	13	13	8	0	3	3	1	1	2	2	4	5	4	4	1	3	1	2	1	3	1	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:9062974C>A	uc002mkp.2	-	3	24676	c.24472G>T	c.(24472-24474)GTC>TTC	p.V8158F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8160	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGGAGGTGACTTCTGTCCTG	0.542													16	75					6.72482e-11	8.61062e-11	1	0	A	9062974	A	A	9062974	3	1	186	1	0	0	0	0	1	0	0	0	10026	565	20	4	19379	4	MUC16	19	9062974	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	3898	9062974	50066009	157	34631											
KEAP1	9817	broad.mit.edu	37	chr19	10610277	10610277	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacttctcgcccatggagaTggaggccgtgtaggcgaatt	9	9	13	10	3	1	1	0	0	1	1	2	4	1	2	2	4	0	1	2	4	2	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:10610277T>A	uc002moq.1	-	2	589	c.433A>T	c.(433-435)ATC>TTC	p.I145F	KEAP1_uc002mor.1_Missense_Mutation_p.I145F	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	145	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCCATGGAGATGGAGGCCGTG	0.592													14	36					0	0	0	0	A	10610277	A	A	10610277	3	1	186	1	0	0	0	0	1	0	0	0	8180	1464	51	5	1461	5	KEAP1	19	10610277	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	1547303	10610277	48518706	158	34632											
SIN3B	23309	broad.mit.edu	37	chr19	16977364	16977364	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatcgagagcgtctacgaCgaggtaaagccttccctagc	11	7	12	11	4	1	2	0	0	1	2	3	6	2	2	2	1	4	1	2	1	4	4	rs138346712	byFrequency	TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:16977364C>T	uc002ney.1	+	13	1913	c.1899C>T	c.(1897-1899)GAC>GAT	p.D633D	SIN3B_uc002nez.1_Silent_p.D601D|SIN3B_uc010xpi.1_Silent_p.D191D	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	633					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						GCGTCTACGACGAGGTAAAGC	0.627													17	22					0	0	0	0	T	16977364	T	T	16977364	2	4	186	1	0	0	0	0	0	0	0	1	14391	535	19	1		1	SIN3B	19	16977364	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	6367087	16977364	42151619	159	34633											
ZNF536	9745	broad.mit.edu	37	chr19	30936564	30936564	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctaacgtcaccgaggagagcGgggtcggaggcggcctctcc	7	5	16	13	5	2	1	1	0	1	1	4	4	2	2	3	6	2	0	3	6	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:30936564G>A	uc002nsu.1	+	2	2233	c.2095G>A	c.(2095-2097)GGG>AGG	p.G699R	ZNF536_uc010edd.1_Missense_Mutation_p.G699R	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	699					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CGAGGAGAGCGGGGTCGGAGG	0.697													14	13					0	0	0	0	A	30936564	A	A	30936564	3	1	186	1	0	0	0	0	1	0	0	0	18041	1116	39	1	2097	1	ZNF536	19	30936564	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	13959200	30936564	28192419	160	34634											
ANKRD27	84079	broad.mit.edu	37	chr19	33131245	33131245	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccgttttcacaagcaagtaTaacaggactgatagcagatc	14	10	8	9	1	1	2	1	1	0	1	3	3	2	3	1	1	3	4	1	1	5	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:33131245T>C	uc002ntn.1	-	11	1107	c.951A>G	c.(949-951)TTA>TTG	p.L317L	ANKRD27_uc002nto.1_Silent_p.L317L	NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	317	VPS9.				early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					CAAGCAAGTATAACAGGACTG	0.353													17	51					0	0	0	0	C	33131245	C	C	33131245	2	2	186	1	0	0	0	0	0	0	0	1	655	1403	49	5		5	ANKRD27	19	33131245	Silent	SNP	T	TCGA-CV-5978-01A-11D-1683-08	2194681	33131245	25997738	161	34635											
LRFN3	79414	broad.mit.edu	37	chr19	36430643	36430643	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccggcgccttcgccgacCtgcgggccctgcgtgccctg	1	7	14	19	6	0	0	0	0	0	0	1	1	0	0	6	2	4	0	6	2	0	1	rs112518812		TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:36430643C>T	uc002oco.2	+	2	768	c.316C>T	c.(316-318)CTG>TTG	p.L106L		NM_024509	NP_078785	Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III	106	Extracellular (Potential).				cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CTTCGCCGACCTGCGGGCCCT	0.706													5	28					0	0	0	0	T	36430643	T	T	36430643	2	4	186	1	0	0	0	0	0	0	0	1	8989	680	24	4		4	LRFN3	19	36430643	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	3299398	36430643	22698340	162	34636											
CLIP3	25999	broad.mit.edu	37	chr19	36517871	36517871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caccgactccgtgggccccaGctttgcacgcatagtggagc	7	7	12	15	3	0	0	0	0	0	0	1	2	1	1	4	2	3	3	4	2	1	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:36517871G>A	uc010eeq.1	-	3	665	c.383C>T	c.(382-384)GCT>GTT	p.A128V	uc002ocy.2_Intron|CLIP3_uc002ocz.1_Missense_Mutation_p.A128V	NM_015526	NP_056341	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	128	ANK 1.				chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GTGGGCCCCAGCTTTGCACGC	0.617													4	34					0	0	0	0	A	36517871	A	A	36517871	3	1	186	1	0	0	0	0	1	0	0	0	3549	971	34	4	1304	4	CLIP3	19	36517871	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	87228	36517871	22611112	163	34637											
FCGBP	8857	broad.mit.edu	37	chr19	40424009	40424009	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggtgatctccagtccccaaCcgagatgccaagctccagac	10	7	9	15	1	1	3	0	1	1	2	4	4	3	3	6	1	3	1	6	1	2	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:40424009C>A	uc002omp.3	-	4	2202	c.2194G>T	c.(2194-2196)GTT>TTT	p.V732F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	732						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CAGTCCCCAACCGAGATGCCA	0.617													18	49					6.49762e-13	8.73569e-13	1	0	A	40424009	A	A	40424009	3	1	186	1	0	0	0	0	1	0	0	0	5810	507	18	4	14155	4	FCGBP	19	40424009	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	3906138	40424009	18704974	164	34638											
CLDND2	125875	broad.mit.edu	37	chr19	51871727	51871729	+	In_Frame_Del	DEL	TTG	-	-																															cacaggccactgtggccctcTtgttggcgggtccagtagtt																										TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:51871727_51871729delTTG	uc002pwi.1	-	1	529_531	c.103_105delCAA	c.(103-105)CAAdel	p.Q35del	ETFB_uc002pwh.2_5'Flank	NM_152353	NP_689566	Q8NHS1	CLDN2_HUMAN	claudin domain containing 2	35						integral to membrane					0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TGTGGCCCTCTTGTTGGCGGGTC	0.64													---	---	---								-	51871729	-	-	51871727	7	5	186	1	0	1	0	1	0	0	0	0	3509	1606	56	0	414	0	CLDND2	19	51871727	In_Frame_Del	DEL	TTG	TCGA-CV-5978-01A-11D-1683-08	11447718	51871727	7257256	165	34639											
ZNF836	162962	broad.mit.edu	37	chr19	52663759	52663759	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agttctccaacatcacatccCagtacaaagctttctgcaca	13	10	4	14	0	3	0	1	0	2	0	5	0	4	0	2	0	4	4	2	0	3	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:52663759C>A	uc010ydi.1	-	4	475	c.101G>T	c.(100-102)TGG>TTG	p.W34L	ZNF836_uc010ydj.1_Missense_Mutation_p.W34L	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	34	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATCACATCCCAGTACAAAGC	0.433													12	84					0.00010058	0.000110137	1	0	A	52663759	A	A	52663759	3	1	186	1	0	0	0	0	1	0	0	0	18254	595	21	4	2715	4	ZNF836	19	52663759	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	792032	52663759	6465224	166	34640											
ZNF264	9422	broad.mit.edu	37	chr19	57723895	57723895	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattcgccacttcagcatccAcactggagagaagccctatg	11	8	8	14	1	1	1	1	0	0	1	3	3	2	2	3	1	2	1	3	1	2	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr19:57723895A>T	uc002qob.2	+	4	1843	c.1430A>T	c.(1429-1431)CAC>CTC	p.H477L		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	477	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		TTCAGCATCCACACTGGAGAG	0.542													9	26					0	0	0	0	T	57723895	T	T	57723895	3	4	186	1	0	0	0	0	1	0	0	0	17871	159	6	5	1444	5	ZNF264	19	57723895	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08	5060136	57723895	1405088	167	34641											
SEL1L2	80343	broad.mit.edu	37	chr20	13846030	13846030	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgctgaattgctttgagctActtcataccccatttctgca	9	15	6	11	0	2	2	1	2	1	0	2	2	2	2	2	0	6	4	2	0	3	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr20:13846030A>G	uc010gcf.2	-	16	1617	c.1535T>C	c.(1534-1536)GTA>GCA	p.V512A	SEL1L2_uc002woq.3_Missense_Mutation_p.V373A|SEL1L2_uc010zrl.1_Intron|SEL1L2_uc002wor.2_Intron	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	512	Extracellular (Potential).					integral to membrane	binding			ovary(2)	2						GCTTTGAGCTACTTCATACCC	0.383													31	76					0	0	0	0	G	13846030	G	G	13846030	3	3	186	1	0	0	0	0	1	0	0	0	14076	391	14	5	551	5	SEL1L2	20	13846030	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08		13846030	49179490	168	34642											
C20orf12	55184	broad.mit.edu	37	chr20	18379176	18379176	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atctcacccacctttcccatCctgggttctgcaatcaaggc	8	11	6	16	0	3	0	2	0	2	0	6	0	5	0	4	2	1	2	4	2	2	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr20:18379176C>T	uc010zsa.1	-	14	1793	c.1584G>A	c.(1582-1584)AGG>AGA	p.R528R	C20orf12_uc010zrz.1_Silent_p.R47R|C20orf12_uc002wqp.3_Silent_p.R219R|C20orf12_uc002wqr.3_RNA|C20orf12_uc002wqs.3_Silent_p.R395R|C20orf12_uc002wqq.3_Silent_p.R509R	NM_001099407	NP_001092877	Q9NVP4	CT012_HUMAN	hypothetical protein LOC55184	336						intracellular	zinc ion binding			ovary(1)	1		Myeloproliferative disorder(85;0.0122)				CCTTTCCCATCCTGGGTTCTG	0.299													23	72					0	0	0	0	T	18379176	T	T	18379176	2	4	186	1	0	0	0	0	0	0	0	1	2095	854	30	2		2	C20orf12	20	18379176	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	4533146	18379176	44646344	169	34643											
ASXL1	171023	broad.mit.edu	37	chr20	31024686	31024686	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaggaaagctactgggcatAgtcccctggaactggtgggt	10	8	14	9	0	0	0	0	0	0	0	1	2	1	2	2	5	3	2	2	5	4	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr20:31024686A>T	uc002wxs.2	+	12	4597	c.4171A>T	c.(4171-4173)AGT>TGT	p.S1391C	ASXL1_uc010geb.2_Missense_Mutation_p.S1282C	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1391					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						TACTGGGCATAGTCCCCTGGA	0.542			F|N|Mis		MDS|CMML								24	102					0	0	0	0	T	31024686	T	T	31024686	3	4	186	1	0	0	0	0	1	0	0	0	1068	420	15	5	4227	5	ASXL1	20	31024686	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08	12645510	31024686	32000834	170	34644											
DSCAM	1826	broad.mit.edu	37	chr21	41711115	41711115	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcagtgcagcggtagactcCcccgtcccggacctgggagc	6	5	15	15	3	0	1	0	0	0	1	2	3	2	3	4	4	3	3	4	4	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr21:41711115C>T	uc002yyq.1	-	7	1890	c.1438G>A	c.(1438-1440)GGA>AGA	p.G480R	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	480	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CGGTAGACTCCCCCGTCCCGG	0.562													17	26					0	0	0	0	T	41711115	T	T	41711115	3	4	186	1	0	0	0	0	1	0	0	0	4790	632	22	4	4708	4	DSCAM	21	41711115	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08		41711115	6418780	171	34645											
C21orf70	85395	broad.mit.edu	37	chr21	46386972	46386972	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgaagccataaaactggctGagcagaagcacagggaggag	15	4	14	8	1	0	2	0	1	0	1	1	5	0	4	1	3	4	3	1	3	4	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr21:46386972G>C	uc002zgl.2	+	4	394	c.376G>C	c.(376-378)GAG>CAG	p.E126Q	C21orf70_uc002zgm.2_Missense_Mutation_p.E111Q	NM_058190	NP_478070	Q9NSI2	CU070_HUMAN	hypothetical protein LOC85395	126											0				Colorectal(79;0.248)		AAAACTGGCTGAGCAGAAGCA	0.637													11	11					0	0	0	0	C	46386972	C	C	46386972	3	2	186	1	0	0	0	0	1	0	0	0	2143	1291	45	2	390	2	C21orf70	21	46386972	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	4675857	46386972	1742923	172	34646											
COL6A1	1291	broad.mit.edu	37	chr21	47423497	47423497	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcacgggccagcagcgccCagagcgggcgtcgctgcagt	6	3	17	15	6	0	1	0	0	0	1	1	1	0	1	2	3	4	4	2	3	0	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr21:47423497C>A	uc002zhu.1	+	35	2759	c.2657C>A	c.(2656-2658)CCA>CAA	p.P886Q	COL6A1_uc010gqd.1_Missense_Mutation_p.P217Q|COL6A1_uc002zhv.1_Missense_Mutation_p.P217Q|COL6A1_uc002zhw.1_5'UTR	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	886	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CAGCAGCGCCCAGAGCGGGCG	0.687													6	25					0.00116845	0.00122409	1	0	A	47423497	A	A	47423497	3	1	186	1	0	0	0	0	1	0	0	0	3714	594	21	4	2795	4	COL6A1	21	47423497	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	1036525	47423497	706398	173	34647											
HMGXB4	10042	broad.mit.edu	37	chr22	35661578	35661578	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagaagagaaggacaaagaGagagagagaggagaaaaggt	23	1	16	1	0	0	6	0	0	0	6	0	12	0	7	0	3	0	0	0	3	6	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr22:35661578G>C	uc003anl.2	+	5	1371	c.1197G>C	c.(1195-1197)GAG>GAC	p.E399D	HMGXB4_uc011amh.1_Missense_Mutation_p.E290D|HMGXB4_uc003ank.2_Missense_Mutation_p.E290D	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	399					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						aggacaaagagagagagagag	0.378													6	21					0	0	0	0	C	35661578	C	C	35661578	3	2	186	1	0	0	0	0	1	0	0	0	7278	933	33	2	1211	2	HMGXB4	22	35661578	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08		35661578	15642988	174	34648											
GGA1	26088	broad.mit.edu	37	chr22	38016247	38016247	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccactgtgtccctgaagtaTctgggctctcggacatcgga	7	10	11	13	2	2	1	0	1	2	0	5	3	3	3	2	3	0	2	2	3	2	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chr22:38016247T>C	uc003atc.2	+	5	671	c.306T>C	c.(304-306)TAT>TAC	p.Y102Y	GGA1_uc003atd.2_Silent_p.Y102Y|GGA1_uc003ate.2_Silent_p.Y102Y|GGA1_uc003atf.2_Silent_p.Y29Y	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	102	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					CCCTGAAGTATCTGGGCTCTC	0.592													51	89					0	0	0	0	C	38016247	C	C	38016247	2	2	186	1	0	0	0	0	0	0	0	1	6389	1442	50	5		5	GGA1	22	38016247	Silent	SNP	T	TCGA-CV-5978-01A-11D-1683-08	2354669	38016247	13288319	175	34649											
TBL1X	6907	broad.mit.edu	37	chrX	9660274	9660274	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtcccgagtaacaaagacGtcacctcactggactggaat	13	7	9	12	3	2	1	2	0	0	1	3	4	3	3	2	2	1	1	2	2	3	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:9660274G>T	uc010ndq.2	+	9	1239	c.871G>T	c.(871-873)GTC>TTC	p.V291F	TBL1X_uc004csq.3_Missense_Mutation_p.V240F|TBL1X_uc010ndr.2_Missense_Mutation_p.V240F|TBL1X_uc004csr.2_Missense_Mutation_p.V291F|TBL1X_uc004css.2_Missense_Mutation_p.V242F	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	291	WD 2.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				TAACAAAGACGTCACCTCACT	0.557													13	51					1.05317e-09	1.31375e-09	1	0	T	9660274	T	T	9660274	3	4	186	1	0	0	0	0	1	0	0	0	15705	1145	40	3	893	3	TBL1X	23	9660274	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08		9660274	145610286	176	34650											
CLCN4	1183	broad.mit.edu	37	chrX	10188916	10188916	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgcctggtgacgcggagcGggtgagtagccggacatgtg	7	7	19	8	4	0	2	0	2	0	0	0	4	0	4	2	4	3	1	2	4	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:10188916G>T	uc004csy.3	+	12	2621	c.2191G>T	c.(2191-2193)GGG>TGG	p.G731W	CLCN4_uc011mid.1_Missense_Mutation_p.G637W	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	731	CBS 2.|Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GACGCGGAGCGGGTGAGTAGC	0.418													21	56					1.55795e-14	2.19199e-14	1	0	T	10188916	T	T	10188916	3	4	186	1	0	0	0	0	1	0	0	0	3480	1130	39	3	2229	3	CLCN4	23	10188916	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	528642	10188916	145081644	177	34651											
CDKL5	6792	broad.mit.edu	37	chrX	18616687	18616687	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcgttctccttcaaggtcaGcaaaaagaaaaccttaccat	15	10	5	11	1	3	1	2	0	1	1	5	1	3	1	3	1	3	2	3	1	6	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:18616687G>T	uc004cym.2	+	11	1184	c.931G>T	c.(931-933)GCA>TCA	p.A311S	CDKL5_uc004cyn.2_Missense_Mutation_p.A311S	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	311					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding	p.A311T(1)		ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					TTCAAGGTCAGCAAAAAGAAA	0.408													14	77					1.5842e-08	1.91688e-08	1	0	T	18616687	T	T	18616687	3	4	186	1	0	0	0	0	1	0	0	0	3172	971	34	4	969	4	CDKL5	23	18616687	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	8427771	18616687	136653873	178	34652											
PHKA2	5256	broad.mit.edu	37	chrX	18972377	18972377	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcagtcactattacctgctCcagctcgtaggccttggcct	6	12	9	14	1	2	0	2	0	0	0	4	0	3	0	4	2	3	3	4	2	3	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:18972377C>A	uc004cyv.3	-	2	662	c.232G>T	c.(232-234)GAG>TAG	p.E78*	PHKA2_uc010nfh.1_RNA|PHKA2_uc010nfi.1_Nonsense_Mutation_p.E20*	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	78					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					ATTACCTGCTCCAGCTCGTAG	0.542													30	75					2.61193e-14	3.65363e-14	1	0	A	18972377	A	A	18972377	4	1	186	1	0	0	0	0	0	1	0	0	11899	864	30	2	3603	2	PHKA2	23	18972377	Nonsense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	355690	18972377	136298183	179	34653											
DMD	1756	broad.mit.edu	37	chrX	32716006	32716006	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgaaggaaatgggctcCgtgtagggtcagaggtggtg	8	9	18	6	1	1	2	1	1	0	1	2	3	2	3	2	5	0	2	2	5	3	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:32716006C>T	uc004dda.1	-	9	1185	c.941G>A	c.(940-942)CGG>CAG	p.R314Q	DMD_uc004dcz.2_Missense_Mutation_p.R191Q|DMD_uc004dcy.1_Missense_Mutation_p.R310Q|DMD_uc004ddb.1_Missense_Mutation_p.R306Q|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.R306Q|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron|DMD_uc010ngr.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	314					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AAATGGGCTCCGTGTAGGGTC	0.453													5	15					0	0	0	0	T	32716006	T	T	32716006	3	4	186	1	0	0	0	0	1	0	0	0	4602	652	23	1	10643	1	DMD	23	32716006	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	13743629	32716006	122554554	180	34654											
FAM47A	158724	broad.mit.edu	37	chrX	34150048	34150048	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcttccacttgctctacgaaCgccttccgtgctagctgggc	5	11	10	15	3	1	0	0	0	1	0	3	1	3	0	3	1	5	4	3	1	3	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:34150048C>A	uc004ddg.2	-	1	381	c.348G>T	c.(346-348)GCG>GCT	p.A116A		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	116										ovary(4)|central_nervous_system(1)	5						GCTCTACGAACGCCTTCCGTG	0.552													16	74					4.14922e-12	5.36958e-12	1	0	A	34150048	A	A	34150048	2	1	186	1	0	0	0	0	0	0	0	1	5601	523	19	3		3	FAM47A	23	34150048	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	1434042	34150048	121120512	181	34655											
BCOR	54880	broad.mit.edu	37	chrX	39913236	39913236	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ataggcatcgtcatcatcatCctggtcttctggtcctgggg	6	13	11	11	1	5	0	3	0	2	0	8	0	7	0	2	5	0	1	2	5	1	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:39913236C>A	uc004den.3	-	14	5171	c.4879G>T	c.(4879-4881)GAT>TAT	p.D1627Y	BCOR_uc004dep.3_Missense_Mutation_p.D1593Y|BCOR_uc004deo.3_Missense_Mutation_p.D1575Y|BCOR_uc010nhb.2_Missense_Mutation_p.D335Y|BCOR_uc004dem.3_Missense_Mutation_p.D1593Y	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1627	Poly-Asp.				heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TCATCATCATCCTGGTCTTCT	0.448													5	21					5.9392e-07	6.97712e-07	1	0	A	39913236	A	A	39913236	3	1	186	1	0	0	0	0	1	0	0	0	1388	855	30	2	396	2	BCOR	23	39913236	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	5763188	39913236	115357324	182	34656											
BCOR	54880	broad.mit.edu	37	chrX	39913587	39913587	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggaggtcatttaaataatCtggagggagagaaaaataaa	18	9	11	3	0	2	1	1	0	1	1	2	5	2	4	0	4	0	0	0	4	7	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:39913587C>T	uc004den.3	-	13	5034	c.4742_splice	c.e13-1	p.D1581_splice	BCOR_uc004dep.3_Splice_Site_p.D1547_splice|BCOR_uc004deo.3_Splice_Site_p.D1529_splice|BCOR_uc010nhb.2_Splice_Site_p.D289_splice|BCOR_uc004dem.3_Splice_Site_p.D1547_splice	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c						heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TTTAAATAATCTGGAGGGAGA	0.423													5	15					0	0	0	0	T	39913587	T	T	39913587	5	4	186	1	0	0	0	0	0	0	1	0	1388	927	32	2	538	2	BCOR	23	39913587	Splice_Site	SNP	C	TCGA-CV-5978-01A-11D-1683-08	351	39913587	115356973	183	34657											
BCOR	54880	broad.mit.edu	37	chrX	39933796	39933796	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggggaggccgaaggtgtcGagagcctcatgggtgatgcc	7	7	18	9	2	1	2	1	1	0	1	2	5	1	3	3	5	2	0	3	5	1	0			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:39933796G>T	uc004den.3	-	4	1095	c.803C>A	c.(802-804)TCG>TAG	p.S268*	BCOR_uc004dep.3_Nonsense_Mutation_p.S268*|BCOR_uc004deo.3_Nonsense_Mutation_p.S268*|BCOR_uc004dem.3_Nonsense_Mutation_p.S268*|BCOR_uc004deq.3_Nonsense_Mutation_p.S268*	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	268					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CGAAGGTGTCGAGAGCCTCAT	0.612													5	16					0.000602214	0.000644849	1	0	T	39933796	T	T	39933796	4	4	186	1	0	0	0	0	0	1	0	0	1388	1059	37	3	4512	3	BCOR	23	39933796	Nonsense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	20209	39933796	115336764	184	34658											
PORCN	64840	broad.mit.edu	37	chrX	48374170	48374170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcacctatgcagccagcGccctcctacatgtgagcagg	8	8	11	14	1	1	1	1	1	0	0	2	1	2	1	4	2	5	2	4	2	2	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:48374170G>A	uc010nie.1	+	11	1170	c.1012G>A	c.(1012-1014)GCC>ACC	p.A338T	PORCN_uc004djr.1_Missense_Mutation_p.A333T|PORCN_uc004djs.1_Missense_Mutation_p.A327T|PORCN_uc004djt.1_Missense_Mutation_p.A256T|PORCN_uc011mlx.1_Missense_Mutation_p.A256T|PORCN_uc004dju.1_Missense_Mutation_p.A196T|PORCN_uc004djv.1_Missense_Mutation_p.A338T|PORCN_uc004djw.1_Missense_Mutation_p.A332T	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	338	Helical; (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						TGCAGCCAGCGCCCTCCTACA	0.567													11	40					0	0	0	0	A	48374170	A	A	48374170	3	1	186	1	0	0	0	0	1	0	0	0	12313	1087	38	1	1050	1	PORCN	23	48374170	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	8440374	48374170	106896390	185	34659											
CLCN5	1184	broad.mit.edu	37	chrX	49853388	49853388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctttatccctagcatggctGttggtgctatagcaggtcga	7	14	11	9	1	1	0	0	0	1	0	3	1	2	0	1	3	3	5	1	3	4	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:49853388G>A	uc004dos.1	+	9	1629	c.1381G>A	c.(1381-1383)GTT>ATT	p.V461I	CLCN5_uc004dor.1_Missense_Mutation_p.V531I|CLCN5_uc004doq.1_Missense_Mutation_p.V531I|CLCN5_uc004dot.1_Missense_Mutation_p.V461I	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	461	Helical; (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					TAGCATGGCTGTTGGTGCTAT	0.483													39	121					0	0	0	0	A	49853388	A	A	49853388	3	1	186	1	0	0	0	0	1	0	0	0	3481	1377	48	4	1629	4	CLCN5	23	49853388	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	1479218	49853388	105417172	186	34660											
HUWE1	10075	broad.mit.edu	37	chrX	53619397	53619397	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgacttgaggttcccggcgGgagccaccttcctcttgccc	4	11	11	15	2	1	2	0	2	1	0	3	3	3	3	5	3	2	1	5	3	0	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:53619397G>A	uc004dsp.2	-	33	4335	c.3933C>T	c.(3931-3933)TCC>TCT	p.S1311S	HUWE1_uc004dsn.2_Silent_p.S136S	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1311					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GTTCCCGGCGGGAGCCACCTT	0.557													28	75					0	0	0	0	A	53619397	A	A	53619397	2	1	186	1	0	0	0	0	0	0	0	1	7500	1219	43	4		4	HUWE1	23	53619397	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	3766009	53619397	101651163	187	34661											
FGD1	2245	broad.mit.edu	37	chrX	54472832	54472832	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccaatgaggggcaggctgcGctgggctttcacatcctggc	6	8	15	12	1	1	1	1	1	0	0	2	1	2	1	2	5	1	4	2	5	1	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:54472832G>C	uc004dtg.2	-	18	3330	c.2596C>G	c.(2596-2598)CGC>GGC	p.R866G		NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	866	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GGCAGGCTGCGCTGGGCTTTC	0.632													10	24					0	0	0	0	C	54472832	C	C	54472832	3	2	186	1	0	0	0	0	1	0	0	0	5864	1087	38	3	293	3	FGD1	23	54472832	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	853435	54472832	100797728	188	34662											
FGD1	2245	broad.mit.edu	37	chrX	54482960	54482960	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accattttgcggatggcagcAttcgagtgctctgctgctgt	6	13	12	10	2	1	0	0	0	1	0	2	2	1	1	1	2	5	5	1	2	0	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:54482960A>T	uc004dtg.2	-	9	2411	c.1677T>A	c.(1675-1677)AAT>AAA	p.N559K	FGD1_uc011moi.1_Missense_Mutation_p.N317K	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	559	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GGATGGCAGCATTCGAGTGCT	0.607													3	28					0	0	0	0	T	54482960	T	T	54482960	3	4	186	1	0	0	0	0	1	0	0	0	5864	214	8	5	1248	5	FGD1	23	54482960	Missense_Mutation	SNP	A	TCGA-CV-5978-01A-11D-1683-08	10128	54482960	100787600	189	34663											
PFKFB1	5207	broad.mit.edu	37	chrX	54985328	54985328	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgcaggatcagtgaccgtcGttctctggtagtgttggtgg	5	13	15	8	2	2	1	1	1	1	0	4	2	2	2	1	4	1	4	1	4	1	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:54985328G>T	uc004dty.1	-	5	486	c.415C>A	c.(415-417)CGA>AGA	p.R139R	PFKFB1_uc010nkd.1_Silent_p.R125R|PFKFB1_uc011mol.1_Silent_p.R74R	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	139	6-phosphofructo-2-kinase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						AGTGACCGTCGTTCTCTGGTA	0.453													32	98					1.26612e-14	1.79181e-14	1	0	T	54985328	T	T	54985328	2	4	186	1	0	0	0	0	0	0	0	1	11815	1153	40	3		3	PFKFB1	23	54985328	Silent	SNP	G	TCGA-CV-5978-01A-11D-1683-08	502368	54985328	100285232	190	34664											
KIAA2022	340533	broad.mit.edu	37	chrX	73962022	73962022	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcatttcagaagagcatgtCgttggtagaaaagtggaact	13	10	13	5	1	1	3	1	0	0	3	2	4	1	4	0	3	2	4	0	3	5	3			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:73962022C>A	uc004eby.2	-	3	2987	c.2370G>T	c.(2368-2370)ACG>ACT	p.T790T		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	790					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						AAGAGCATGTCGTTGGTAGAA	0.403													4	67					1.23904e-05	1.39464e-05	1	0	A	73962022	A	A	73962022	2	1	186	1	0	0	0	0	0	0	0	1	8308	871	31	3		3	KIAA2022	23	73962022	Silent	SNP	C	TCGA-CV-5978-01A-11D-1683-08	18976694	73962022	81308538	191	34665											
ATRX	546	broad.mit.edu	37	chrX	76938250	76938250	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttttttggtggttctggcaGcaccaattttactcatgctc	6	18	8	9	0	2	0	1	0	1	0	3	0	2	0	1	3	3	4	1	3	2	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:76938250G>T	uc004ecp.3	-	9	2730	c.2498C>A	c.(2497-2499)GCT>GAT	p.A833D	ATRX_uc004ecq.3_Missense_Mutation_p.A795D|ATRX_uc004eco.3_Missense_Mutation_p.A618D|ATRX_uc004ecr.2_Missense_Mutation_p.A765D|ATRX_uc010nlx.1_Missense_Mutation_p.A804D|ATRX_uc010nly.1_Missense_Mutation_p.A778D	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	833					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GGTTCTGGcagcaccaatttt	0.224			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						22	154					2.37509e-13	3.22906e-13	1	0	T	76938250	T	T	76938250	3	4	186	1	0	0	0	0	1	0	0	0	1210	971	34	4	5088	4	ATRX	23	76938250	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	2976228	76938250	78332310	192	34666											
GLA	2717	broad.mit.edu	37	chrX	100656686	100656686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagcagatctactccccagtCagcaaaggtctgggcatcaa	12	8	9	12	0	4	1	2	0	2	1	5	1	5	1	2	2	3	3	2	2	4	2			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:100656686C>T	uc004ehl.1	-	3	591	c.481G>A	c.(481-483)GAC>AAC	p.D161N	GLA_uc011mrj.1_Missense_Mutation_p.D161N	NM_000169	NP_000160	P06280	AGAL_HUMAN	alpha-galactosidase A precursor	161					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding				0					Agalsidase beta(DB00103)	ACTCCCCAGTCAGCAAAGGTC	0.433													52	85					0	0	0	0	T	100656686	T	T	100656686	3	4	186	1	0	0	0	0	1	0	0	0	6463	826	29	2	828	2	GLA	23	100656686	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	23718436	100656686	54613874	193	34667											
NRK	203447	broad.mit.edu	37	chrX	105153085	105153085	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcatgccactacaggcacaGgttagggcacctaggcttct	9	9	10	13	0	2	0	1	0	1	0	2	0	2	0	2	4	2	4	2	4	3	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:105153085G>T	uc004emd.2	+	13	1755	c.1452G>T	c.(1450-1452)CAG>CAT	p.Q484H	NRK_uc010npc.1_Missense_Mutation_p.Q152H	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	484	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TACAGGCACAGGTTAGGGCAC	0.542										HNSCC(51;0.14)			5	39					1.024e-07	1.23288e-07	1	0	T	105153085	T	T	105153085	3	4	186	1	0	0	0	0	1	0	0	0	10709	991	35	4	1502	4	NRK	23	105153085	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	4496399	105153085	50117475	194	34668											
PLS3	5358	broad.mit.edu	37	chrX	114869295	114869295	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggaaacctcatctggttttgGgactgctttggcagatcatt	8	14	11	8	0	3	1	2	0	1	1	3	3	3	3	1	4	2	3	1	4	1	4			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:114869295G>A	uc004eqd.2	+	7	1075	c.685G>A	c.(685-687)GGA>AGA	p.G229R	PLS3_uc010nqg.2_Intron|PLS3_uc011mtf.1_Missense_Mutation_p.G207R|PLS3_uc004eqe.2_Missense_Mutation_p.G229R|PLS3_uc011mtg.1_Missense_Mutation_p.G202R|PLS3_uc011mth.1_Missense_Mutation_p.G184R	NM_005032	NP_005023	P13797	PLST_HUMAN	plastin 3	229	Actin-binding 1.|CH 1.					cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2						TCTGGTTTTGGGACTGCTTTG	0.438													11	112					0	0	0	0	A	114869295	A	A	114869295	3	1	186	1	0	0	0	0	1	0	0	0	12163	1233	43	4	707	4	PLS3	23	114869295	Missense_Mutation	SNP	G	TCGA-CV-5978-01A-11D-1683-08	9716210	114869295	40401265	195	34669											
SLC25A14	9016	broad.mit.edu	37	chrX	129484680	129484680	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggagtgatatcttccactaTagccaatcccaccgatgttc	11	11	7	12	1	1	1	0	1	1	0	4	3	3	2	4	1	1	1	4	1	4	5			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:129484680T>C	uc004evn.1	+	6	686	c.473T>C	c.(472-474)ATA>ACA	p.I158T	SLC25A14_uc011mut.1_Intron|SLC25A14_uc011muu.1_Missense_Mutation_p.I158T|SLC25A14_uc010nrg.2_Missense_Mutation_p.I155T|SLC25A14_uc004evo.1_Intron|SLC25A14_uc004evp.1_Missense_Mutation_p.I158T|SLC25A14_uc004evq.1_Missense_Mutation_p.I155T|SLC25A14_uc004evr.1_Missense_Mutation_p.I155T	NM_003951	NP_003942	O95258	UCP5_HUMAN	solute carrier family 25, member 14 isoform	158	Solcar 2.|Helical; Name=3; (Potential).				aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			ovary(1)	1						TCTTCCACTATAGCCAATCCC	0.239													6	58					0	0	0	0	C	129484680	C	C	129484680	3	2	186	1	0	0	0	0	1	0	0	0	14540	1406	49	5	491	5	SLC25A14	23	129484680	Missense_Mutation	SNP	T	TCGA-CV-5978-01A-11D-1683-08	14615385	129484680	25785880	196	34670											
GPR101	83550	broad.mit.edu	37	chrX	136112567	136112567	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttcgacatccacccacaCggccaggactgctaaaaagc	12	6	9	14	2	0	0	0	0	0	0	2	2	1	1	3	3	2	2	3	3	3	2	rs143030995	byFrequency	TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:136112567C>T	uc011mwh.1	-	1	1267	c.1267G>A	c.(1267-1269)GTG>ATG	p.V423M		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	423	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					TCCACCCACACGGCCAGGACT	0.517													8	57					0	0	0	0	T	136112567	T	T	136112567	3	4	186	1	0	0	0	0	1	0	0	0	6660	536	19	1	262	1	GPR101	23	136112567	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	6627887	136112567	19157993	197	34671											
SLC6A8	6535	broad.mit.edu	37	chrX	152960179	152960179	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattctggtccgtagggcatCttcatcttcaacgttgtgta	7	15	9	10	2	5	0	2	0	3	0	6	0	6	0	1	2	1	4	1	2	3	6			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:152960179C>G	uc004fib.3	+	12	1880	c.1602C>G	c.(1600-1602)ATC>ATG	p.I534M	SLC6A8_uc004fic.3_Missense_Mutation_p.I524M|SLC6A8_uc011myx.1_Missense_Mutation_p.I419M|SLC6A8_uc010nuj.2_RNA	NM_005629	NP_005620	P48029	SC6A8_HUMAN	solute carrier family 6 member 8 isoform 1	534	Helical; (Potential).				creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	CGTAGGGCATCTTCATCTTCA	0.433													10	30					0	0	0	0	G	152960179	G	G	152960179	3	3	186	1	0	0	0	0	1	0	0	0	14754	903	32	2	1648	2	SLC6A8	23	152960179	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	16847612	152960179	2310381	198	34672											
NAA10	8260	broad.mit.edu	37	chrX	153195468	153195468	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgagtcggaggcctctgagCtgtccttgacatctgtgctc	5	12	12	12	1	2	3	0	3	2	0	5	4	3	4	2	2	2	2	2	2	0	1			TCGA-CV-5978-01A-11D-1683-08	TCGA-CV-5978-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	791d4f3f-90e0-4fa5-9671-9b5f04ed3eca	341f596e-2ef6-46bb-a500-80ce88e51f36	g.chrX:153195468C>A	uc004fjm.1	-	8	791	c.680G>T	c.(679-681)AGC>ATC	p.S227I	NAA10_uc004fjn.1_Missense_Mutation_p.S212I	NM_003491	NP_003482	P41227	NAA10_HUMAN	alpha-N-acetyltransferase 1A	227					DNA packaging|internal protein amino acid acetylation|N-terminal protein amino acid acetylation	cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)	1						GGCCTCTGAGCTGTCCTTGAC	0.602													5	62					0.00116845	0.00122409	1	0	A	153195468	A	A	153195468	3	1	186	1	0	0	0	0	1	0	0	0	10169	797	28	4	31	4	NAA10	23	153195468	Missense_Mutation	SNP	C	TCGA-CV-5978-01A-11D-1683-08	235289	153195468	2075092	199	34673											
NOS1AP	9722	broad.mit.edu	37	chr1	162124256	162124256	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagatcgtggctgccatgcGccggatacgggtgagtggcc	6	7	18	10	4	0	2	0	1	0	1	1	4	0	3	3	5	3	1	3	5	1	1			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr1:162124256G>A	uc001gbv.2	+	2	554	c.167G>A	c.(166-168)CGC>CAC	p.R56H	NOS1AP_uc010pkr.1_Missense_Mutation_p.R56H|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Missense_Mutation_p.R56H	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	56	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding	p.R56H(2)		lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GCTGCCATGCGCCGGATACGG	0.607													10	15					0	0	0	0	A	162124256	A	A	162124256	3	1	187	1	0	0	0	0	1	0	0	0	10596	1087	38	1	173	1	NOS1AP	1	162124256	Missense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08		162124256	87126365	1	34674											
PIGC	5279	broad.mit.edu	37	chr1	172411036	172411036	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagcactaatggacagtaGgcctcccacggctgaaaatg	13	6	10	12	1	0	1	0	1	0	0	1	2	1	2	2	3	1	3	2	3	4	2			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr1:172411036G>A	uc001gil.2	-	2	1008	c.727C>T	c.(727-729)CTA>TTA	p.L243L	PIGC_uc001gii.1_Intron|PIGC_uc001gij.1_Intron|C1orf105_uc001gik.2_Intron|PIGC_uc001gin.2_Silent_p.L243L|PIGC_uc001gio.2_Silent_p.L243L	NM_153747	NP_714969	Q92535	PIGC_HUMAN	phosphatidylinositol glycan, class C	243	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			lung(1)	1						ATGGACAGTAGGCCTCCCACG	0.498													44	30					0	0	0	0	A	172411036	A	A	172411036	2	1	187	1	0	0	0	0	0	0	0	1	11941	991	35	4		4	PIGC	1	172411036	Silent	SNP	G	TCGA-CV-5979-01A-11D-1683-08	10286780	172411036	76839585	2	34675											
ASPM	259266	broad.mit.edu	37	chr1	197112489	197112489	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgaagaacagttgggggtaAgactaagtttactattctct	12	14	10	5	0	1	3	0	1	1	2	2	3	1	3	0	2	2	3	0	2	6	8			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr1:197112489A>G	uc001gtu.2	-	3	1150	c.893T>C	c.(892-894)CTT>CCT	p.L298P	ASPM_uc001gtv.2_Missense_Mutation_p.L298P|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	298					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GTTGGGGGTAAGACTAAGTTT	0.318													38	63					0	0	0	0	G	197112489	G	G	197112489	3	3	187	1	0	0	0	0	1	0	0	0	1058	72	3	5	9644	5	ASPM	1	197112489	Missense_Mutation	SNP	A	TCGA-CV-5979-01A-11D-1683-08	24701453	197112489	52138132	3	34676											
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200827083	200827083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacagtttagccacatacccGctaaaactttatctgccagt	13	11	5	12	1	1	0	0	0	1	0	1	0	1	0	3	0	5	2	3	0	6	6			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr1:200827083G>A	uc001gvl.2	+	18	4636	c.4366G>A	c.(4366-4368)GCT>ACT	p.A1456T	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.A1445T|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.A1429T	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1456	CKK.					cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CCACATACCCGCTAAAACTTT	0.373													4	157					0	0	0	0	A	200827083	A	A	200827083	3	1	187	1	0	0	0	0	1	0	0	0	2624	1087	38	1	4399	1	CAMSAP1L1	1	200827083	Missense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08	3714594	200827083	48423538	4	34677											
XIRP2	129446	broad.mit.edu	37	chr2	168105632	168105632	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttaaaactcaaagccaaaAtcaacacataacagaggtgg	19	7	7	8	0	2	1	2	0	0	1	2	1	2	1	1	2	4	1	1	2	7	2			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr2:168105632A>G	uc002udx.2	+	8	7748	c.7730A>G	c.(7729-7731)AAT>AGT	p.N2577S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.N2402S|XIRP2_uc010fpq.2_Missense_Mutation_p.N2355S|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2402					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAAAGCCAAAATCAACACATA	0.343													51	55					0	0	0	0	G	168105632	G	G	168105632	3	3	187	1	0	0	0	0	1	0	0	0	17498	101	4	5	7760	5	XIRP2	2	168105632	Missense_Mutation	SNP	A	TCGA-CV-5979-01A-11D-1683-08		168105632	75093741	5	34678											
DOCK3	1795	broad.mit.edu	37	chr3	51198105	51198105	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcacagaagtaaaggaaGaaaaggattttgttcttaag	17	10	9	5	0	2	2	1	0	1	2	2	4	2	4	0	2	0	2	0	2	7	5			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr3:51198105G>T	uc011bds.1	+	12	1032	c.1009G>T	c.(1009-1011)GAA>TAA	p.E337*		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	337						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AGTAAAGGAAGAAAAGGATTT	0.438													5	7					0.000602214	0.000669127	1	0	T	51198105	T	T	51198105	4	4	187	1	0	0	0	0	0	1	0	0	4710	943	33	2	1055	2	DOCK3	3	51198105	Nonsense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08		51198105	146824325	6	34679											
CLDN18	51208	broad.mit.edu	37	chr3	137749947	137749947	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcccgcacagaggacgaGgtacaatcttatccttccaa	11	8	10	12	2	1	1	0	0	1	1	3	3	3	2	3	3	2	2	3	3	4	3			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr3:137749947G>T	uc003ero.1	+	5	803	c.750G>T	c.(748-750)GAG>GAT	p.E250D	CLDN18_uc003erp.1_Missense_Mutation_p.E250D|CLDN18_uc010hue.1_Missense_Mutation_p.E206D	NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	250	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity	p.E250D(2)		upper_aerodigestive_tract(1)|ovary(1)	2						CAGAGGACGAGGTACAATCTT	0.517													46	66					3.7052e-28	4.83287e-28	1	0	T	137749947	T	T	137749947	3	4	187	1	0	0	0	0	1	0	0	0	3494	991	35	4	992	4	CLDN18	3	137749947	Missense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08	86551842	137749947	60272483	7	34680											
FGB	2244	broad.mit.edu	37	chr4	155490819	155490819	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccaacaaataccagatctCagtgaacaaatacagaggaa	20	5	7	9	0	1	3	1	1	1	2	2	4	1	4	2	1	5	0	2	1	7	2			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr4:155490819C>T	uc003ioa.3	+	7	1151	c.1112C>T	c.(1111-1113)TCA>TTA	p.S371L	FGB_uc003iob.3_Intron|FGB_uc010ipv.2_Missense_Mutation_p.S309L|FGB_uc010ipw.2_Intron|FGB_uc003ioc.3_Missense_Mutation_p.S152L	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	371	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding	p.S371L(1)		ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TACCAGATCTCAGTGAACAAA	0.448													21	42					0	0	0	0	T	155490819	T	T	155490819	3	4	187	1	0	0	0	0	1	0	0	0	5863	838	29	2	1138	2	FGB	4	155490819	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08		155490819	35663457	8	34681											
PCDHB11	56125	broad.mit.edu	37	chr5	140581481	140581481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctcctgttcgtggcggtgCggctgtgcaggaggagcagg	4	9	19	9	3	0	0	0	0	0	0	2	2	1	2	1	6	4	5	1	6	0	1			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr5:140581481C>T	uc003liy.2	+	1	2134	c.2134C>T	c.(2134-2136)CGG>TGG	p.R712W	PCDHB11_uc011daj.1_Missense_Mutation_p.R347W	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	712	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGTGGCGGTGCGGCTGTGCAG	0.682													5	105					0	0	0	0	T	140581481	T	T	140581481	3	4	187	1	0	0	0	0	1	0	0	0	11590	759	27	1	2136	1	PCDHB11	5	140581481	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08		140581481	40333779	9	34682											
GCNT2	2651	broad.mit.edu	37	chr6	10529618	10529618	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggcttccaagaaggagtcGgttgtctatggggggatctc	7	11	15	8	1	2	1	0	0	2	1	5	3	3	3	1	6	0	2	1	6	3	3			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr6:10529618G>A	uc010joo.2	+	3	1025	c.474G>A	c.(472-474)TCG>TCA	p.S158S	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Silent_p.S157S|GCNT2_uc010jon.2_Silent_p.S157S	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	158	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AGAAGGAGTCGGTTGTCTATG	0.532													15	21					0	0	0	0	A	10529618	A	A	10529618	2	1	187	1	0	0	0	0	0	0	0	1	6336	1103	39	1		1	GCNT2	6	10529618	Silent	SNP	G	TCGA-CV-5979-01A-11D-1683-08		10529618	160585449	10	34683											
NCR3	259197	broad.mit.edu	37	chr6	31557388	31557388	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcccgaaggaggaggactgtAccagcccctagctgaggatg	10	5	15	11	1	0	1	0	1	0	0	0	6	0	5	4	4	3	2	4	4	3	2			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr6:31557388A>C	uc003nuv.2	-	3	675	c.411T>G	c.(409-411)GGT>GGG	p.G137G	NCR3_uc003nuw.2_Silent_p.G137G|NCR3_uc003nux.1_Silent_p.G137G	NM_147130	NP_667341	O14931	NCTR3_HUMAN	natural cytotoxicity triggering receptor 3	137	Helical; (Potential).				cell recognition|immune response|inflammatory response|positive regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						GGAGGACTGTACCAGCCCCTA	0.582													6	20					0	0	0	0	C	31557388	C	C	31557388	2	2	187	1	0	0	0	0	0	0	0	1	10293	378	14	5		5	NCR3	6	31557388	Silent	SNP	A	TCGA-CV-5979-01A-11D-1683-08	21027770	31557388	139557679	11	34684											
EGFL8	80864	broad.mit.edu	37	chr6	32134741	32134741	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgttaggcctgaccagtGcgagtgcgcccccggctggg	4	7	16	14	4	0	1	0	1	0	0	0	2	0	1	4	3	3	2	4	3	1	1			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr6:32134741G>T	uc003oab.1	+	5	447	c.389G>T	c.(388-390)TGC>TTC	p.C130F	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Missense_Mutation_p.C130F	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	130	EGF-like 1.					extracellular region|integral to membrane	calcium ion binding				0						CCTGACCAGTGCGAGTGCGCC	0.652													4	95					0.00024832	0.000281117	1	0	T	32134741	T	T	32134741	3	4	187	1	0	0	0	0	1	0	0	0	4987	1319	46	4	403	4	EGFL8	6	32134741	Missense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08	577353	32134741	138980326	12	34685											
ECT2L	345930	broad.mit.edu	37	chr6	139167808	139167808	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atatcatcccggattcctgcGtatgaggtagagtatgttat	10	14	10	7	2	1	2	1	1	0	1	3	3	3	3	2	2	1	4	2	2	5	6			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr6:139167808G>A	uc003qif.1	+	6	1000	c.897G>A	c.(895-897)GCG>GCA	p.A299A	ECT2L_uc011edq.1_Silent_p.A230A	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	299					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						GGATTCCTGCGTATGAGGTAG	0.383													104	145					0	0	0	0	A	139167808	A	A	139167808	2	1	187	1	0	0	0	0	0	0	0	1	4924	1132	40	1		1	ECT2L	6	139167808	Silent	SNP	G	TCGA-CV-5979-01A-11D-1683-08	107033067	139167808	31947259	13	34686											
SHPRH	257218	broad.mit.edu	37	chr6	146276439	146276439	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaccctcactggaggagcaCgtttccgtcggctgctcatt	6	11	10	14	3	2	0	2	0	0	0	4	2	3	2	2	3	3	4	2	3	1	3			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr6:146276439C>T	uc003qlf.2	-	2	419	c.20G>A	c.(19-21)CGT>CAT	p.R7H	SHPRH_uc003qld.2_Missense_Mutation_p.R7H|SHPRH_uc003qle.2_Missense_Mutation_p.R7H|SHPRH_uc003qlg.1_Translation_Start_Site|SHPRH_uc003qlj.1_Missense_Mutation_p.R7H|SHPRH_uc003qlk.1_Missense_Mutation_p.R7H	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	7					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TGGAGGAGCACGTTTCCGTCG	0.428													42	55					0	0	0	0	T	146276439	T	T	146276439	3	4	187	1	0	0	0	0	1	0	0	0	14356	536	19	1	5191	1	SHPRH	6	146276439	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08	7108631	146276439	24838628	14	34687											
ANK1	286	broad.mit.edu	37	chr8	41530033	41530033	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctggcagcttctcttctgaCctctgaccttcctcctgttc	3	15	6	17	0	3	2	0	2	3	0	7	2	5	2	5	1	1	3	5	1	0	4			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr8:41530033C>G	uc003xok.2	-	38	5019	c.4935G>C	c.(4933-4935)AGG>AGC	p.R1645S	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.R1645S|ANK1_uc003xoj.2_Missense_Mutation_p.R1645S|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Missense_Mutation_p.R1686S	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1645	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCTCTTCTGACCTCTGACCTT	0.537													7	177					0	0	0	0	G	41530033	G	G	41530033	3	3	187	1	0	0	0	0	1	0	0	0	620	506	18	4	1056	4	ANK1	8	41530033	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08		41530033	104833989	15	34688											
FAM135B	51059	broad.mit.edu	37	chr8	139164859	139164859	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcccctcttgatctattcccTttcctagagtacttaattca	8	17	3	13	0	3	2	1	1	2	1	6	2	6	2	4	0	1	1	4	0	4	8			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr8:139164859T>A	uc003yuy.2	-	13	2030	c.1859A>T	c.(1858-1860)AAG>ATG	p.K620M	FAM135B_uc003yux.2_Missense_Mutation_p.K521M|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.K182M|FAM135B_uc003yvb.2_Missense_Mutation_p.K182M	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	620										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATCTATTCCCTTTCCTAGAGT	0.473										HNSCC(54;0.14)			39	88					0	0	0	0	A	139164859	A	A	139164859	3	1	187	1	0	0	0	0	1	0	0	0	5477	1609	56	5	2393	5	FAM135B	8	139164859	Missense_Mutation	SNP	T	TCGA-CV-5979-01A-11D-1683-08	97634826	139164859	7199163	16	34689											
PFKP	5214	broad.mit.edu	37	chr10	3178006	3178006	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatttttcaacctgtggcagAgctgaagaagcaaacggatt	13	11	10	7	1	1	3	1	1	0	2	1	4	1	4	1	2	4	3	1	2	5	4			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr10:3178006A>G	uc001igp.2	+	21	2237	c.2201A>G	c.(2200-2202)GAG>GGG	p.E734G	PFKP_uc001igq.2_Missense_Mutation_p.E726G|PFKP_uc009xhr.2_Missense_Mutation_p.E696G|PFKP_uc009xht.2_Missense_Mutation_p.E472G|PFKP_uc009xhu.2_Missense_Mutation_p.E240G	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	734					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding	p.E734G(1)		upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		CCTGTGGCAGAGCTGAAGAAG	0.413													26	6					0	0	0	0	G	3178006	G	G	3178006	3	3	187	1	0	0	0	0	1	0	0	0	11821	304	11	5	2283	5	PFKP	10	3178006	Missense_Mutation	SNP	A	TCGA-CV-5979-01A-11D-1683-08		3178006	132356741	17	34690											
KNDC1	85442	broad.mit.edu	37	chr10	135026377	135026377	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggggccctacttcctgaCggagtacagcactcaccagc	10	6	11	14	1	1	1	1	1	0	0	2	3	2	2	3	3	4	2	3	3	3	3			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr10:135026377C>T	uc001llz.1	+	24	4395	c.4394C>T	c.(4393-4395)ACG>ATG	p.T1465M		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1465					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction			p.T1465M(1)		upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TACTTCCTGACGGAGTACAGC	0.657													17	22					0	0	0	0	T	135026377	T	T	135026377	3	4	187	1	0	0	0	0	1	0	0	0	8465	536	19	1	4488	1	KNDC1	10	135026377	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08	131848371	135026377	508370	18	34691											
ODF3	113746	broad.mit.edu	37	chr11	198284	198284	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccggacaaaggcattccgAgtggacagcaccccaggtcc	10	4	12	15	2	0	0	0	0	0	0	2	3	2	2	5	4	1	2	5	4	1	1			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr11:198284A>G	uc001lob.2	+	4	690	c.396A>G	c.(394-396)CGA>CGG	p.R132R	ODF3_uc010qvk.1_Silent_p.R132R|ODF3_uc001loc.2_3'UTR	NM_053280	NP_444510	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3	132					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm				ovary(1)	1		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGGCATTCCGAGTGGACAGCA	0.607													7	19					0	0	0	0	G	198284	G	G	198284	2	3	187	1	0	0	0	0	0	0	0	1	10883	291	11	5		5	ODF3	11	198284	Silent	SNP	A	TCGA-CV-5979-01A-11D-1683-08		198284	134808232	19	34692											
MRPL17	63875	broad.mit.edu	37	chr11	6704488	6704488	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggcccatacggcgaaataCgcggccatgggagatcgctg	10	5	15	11	5	0	1	0	0	0	1	1	4	0	1	2	4	2	1	2	4	3	2			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr11:6704488C>T	uc001men.2	-	1	145	c.40G>A	c.(40-42)GTA>ATA	p.V14I		NM_022061	NP_071344	Q9NRX2	RM17_HUMAN	mitochondrial ribosomal protein L17 precursor	14					translation	ribosome	protein domain specific binding|structural constituent of ribosome				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CGGCGAAATACGCGGCCATGG	0.637											OREG0020719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	33					0	0	0	0	T	6704488	T	T	6704488	3	4	187	1	0	0	0	0	1	0	0	0	9835	536	19	1	499	1	MRPL17	11	6704488	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08	6506204	6704488	128302028	20	34693											
MTMR2	8898	broad.mit.edu	37	chr11	95569371	95569371	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacccagagctctaggtggcGcatgctggctactggataaa	10	8	12	11	1	1	1	0	0	1	1	1	2	1	2	1	4	3	4	1	4	4	3			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr11:95569371G>A	uc001pfu.2	-	14	1964	c.1711C>T	c.(1711-1713)CGC>TGC	p.R571C	MTMR2_uc001pfv.2_Missense_Mutation_p.R499C|MTMR2_uc001pfs.2_Missense_Mutation_p.R499C|MTMR2_uc001pft.2_Missense_Mutation_p.R499C	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	571	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TCTAGGTGGCGCATGCTGGCT	0.453													5	291					0	0	0	0	A	95569371	A	A	95569371	3	1	187	1	0	0	0	0	1	0	0	0	9997	1087	38	1	228	1	MTMR2	11	95569371	Missense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08	88864883	95569371	39437145	21	34694											
MYL6B	140465	broad.mit.edu	37	chr12	56547746	56547746	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtgaagaaaccagcagggcCctccatctccaaacctgctg	11	6	9	15	1	1	2	0	1	1	1	3	2	2	2	5	1	4	2	5	1	3	0			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr12:56547746C>A	uc001sjs.2	+	2	171	c.44C>A	c.(43-45)CCC>CAC	p.P15H	MYL6B_uc009zoo.2_Missense_Mutation_p.P15H|MYL6B_uc001sjt.2_Missense_Mutation_p.P15H|MYL6B_uc001sju.1_Missense_Mutation_p.P15H	NM_002475	NP_002466	P14649	MYL6B_HUMAN	smooth muscle and non-muscle myosin alkali light	15					muscle filament sliding|skeletal muscle tissue development	cytosol|muscle myosin complex|unconventional myosin complex	calcium ion binding|motor activity|protein binding|structural constituent of muscle				0			OV - Ovarian serous cystadenocarcinoma(18;0.0979)			CCAGCAGGGCCCTCCATCTCC	0.587													3	37					0.004672	0.00491789	1	0	A	56547746	A	A	56547746	3	1	187	1	0	0	0	0	1	0	0	0	10105	623	22	4	46	4	MYL6B	12	56547746	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08		56547746	77304149	22	34695											
RFX4	5992	broad.mit.edu	37	chr12	107113755	107113755	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtatatcaggagtttgacCatctcttggaggagcagtct	10	12	11	8	0	3	1	1	1	2	0	4	4	3	4	1	3	1	3	1	3	2	4			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr12:107113755C>A	uc001tlr.2	+	12	1222	c.1156C>A	c.(1156-1158)CAT>AAT	p.H386N	RFX4_uc001tls.2_Missense_Mutation_p.H395N|RFX4_uc001tlt.2_Missense_Mutation_p.H395N|RFX4_uc001tlv.2_Missense_Mutation_p.H292N	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	386	Necessary for dimerization.				transcription, DNA-dependent	nucleus	DNA binding	p.H386N(1)		upper_aerodigestive_tract(1)	1						GGAGTTTGACCATCTCTTGGA	0.473													16	39					8.28177e-16	1.05725e-15	1	0	A	107113755	A	A	107113755	3	1	187	1	0	0	0	0	1	0	0	0	13330	594	21	4	1375	4	RFX4	12	107113755	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08	50566009	107113755	26738140	23	34696											
OR4Q3	441669	broad.mit.edu	37	chr14	20216155	20216155	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaagtcatcaagctggcctGcatggacacctatgtggtag	11	9	11	10	0	2	0	2	0	0	0	2	1	2	1	2	3	2	3	2	3	4	2			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr14:20216155G>A	uc010tkt.1	+	1	569	c.569G>A	c.(568-570)TGC>TAC	p.C190Y		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAGCTGGCCTGCATGGACACC	0.483													17	53					0	0	0	0	A	20216155	A	A	20216155	3	1	187	1	0	0	0	0	1	0	0	0	11135	1319	46	4	571	4	OR4Q3	14	20216155	Missense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08		20216155	87133385	24	34697											
RPGRIP1	57096	broad.mit.edu	37	chr14	21762877	21762877	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccttgagcaggatgaacCgggaggaattggaggacagt	12	6	15	8	1	0	2	0	2	0	0	0	7	0	7	2	5	2	1	2	5	2	2			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr14:21762877C>T	uc001wag.2	+	2	127	c.127C>T	c.(127-129)CGG>TGG	p.R43W		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	43					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CAGGATGAACCGGGAGGAATT	0.408													16	25					0	0	0	0	T	21762877	T	T	21762877	3	4	187	1	0	0	0	0	1	0	0	0	13614	643	23	1	133	1	RPGRIP1	14	21762877	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08	1546722	21762877	85586663	25	34698											
FNTB	2342	broad.mit.edu	37	chr14	65453494	65453494	+	5'Flank	DEL	G	-	-																															cagcagctcctctgcccaatGgggggcggcagcatctcagt																								rs3215788		TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr14:65453494delG	uc001xia.2	+						FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|uc001xib.2_5'Flank	NM_002028	NP_002019	P49356	FNTB_HUMAN	farnesyltransferase, CAAX box, beta						protein farnesylation	microtubule associated complex	protein binding|protein farnesyltransferase activity			ovary(1)	1				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		TCTGCCCAATGGGGGGCGGCA	0.557											OREG0022738	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	65453494	-	-	65453494	6	5	187	0	1	1	0	1	0	0	0	0	6010	1363	47	0		0	FNTB	14	65453494	5'Flank	DEL	G	TCGA-CV-5979-01A-11D-1683-08	43690617	65453494	41896046	26	34699											
MAP1A	4130	broad.mit.edu	37	chr15	43821514	43821514	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gggccccaggcaaggccaagCcagcgtcccctgcacggcgt	7	3	14	17	3	0	0	0	0	0	0	1	0	1	0	6	4	3	2	6	4	2	0			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr15:43821514C>A	uc001zrt.2	+	4	8310	c.7843C>A	c.(7843-7845)CCA>ACA	p.P2615T		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2615						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CAAGGCCAAGCCAGCGTCCCC	0.662													25	22					2.79863e-10	3.35836e-10	1	0	A	43821514	A	A	43821514	3	1	187	1	0	0	0	0	1	0	0	0	9280	739	26	4	7845	4	MAP1A	15	43821514	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08		43821514	58709878	27	34700											
CEP152	22995	broad.mit.edu	37	chr15	49097837	49097837	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtgccacactgccaaagtCtaatgacatggtcctcctgt	10	11	8	12	0	1	1	0	1	1	0	3	1	3	1	4	1	2	0	4	1	3	2			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr15:49097837C>A	uc001zwy.2	-	2	44	c.10G>T	c.(10-12)GAC>TAC	p.D4Y	CEP152_uc001zwz.2_Missense_Mutation_p.D4Y|CEP152_uc001zxa.1_Missense_Mutation_p.D4Y	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	4					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CTGCCAAAGTCTAATGACATG	0.398													4	63					2.56e-06	2.95385e-06	1	0	A	49097837	A	A	49097837	3	1	187	1	0	0	0	0	1	0	0	0	3263	913	32	2	5054	2	CEP152	15	49097837	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08	5276323	49097837	53433555	28	34701											
TEX9	374618	broad.mit.edu	37	chr15	56665657	56665657	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggcgtttaaatgcagaattGcaggcaaaaacagctgacgt	15	8	11	7	2	0	2	0	1	0	1	0	2	0	2	0	2	4	5	0	2	5	3			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr15:56665657G>T	uc002adp.2	+	3	143	c.138G>T	c.(136-138)TTG>TTT	p.L46F	TEX9_uc002ado.1_Missense_Mutation_p.L46F|TEX9_uc010ugl.1_5'UTR|TEX9_uc002adq.1_5'UTR	NM_198524	NP_940926	Q8N6V9	TEX9_HUMAN	testis expressed 9	46											0				all cancers(107;0.0394)|GBM - Glioblastoma multiforme(80;0.056)		ATGCAGAATTGCAGGCAAAAA	0.269													10	10					1.61879e-10	1.98219e-10	1	0	T	56665657	T	T	56665657	3	4	187	1	0	0	0	0	1	0	0	0	15850	1310	46	4	148	4	TEX9	15	56665657	Missense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08	7567820	56665657	45865735	29	34702											
ZCCHC14	23174	broad.mit.edu	37	chr16	87445930	87445930	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attgcagggggcacacttatTtgcacattattaggacagga	12	11	11	7	0	0	0	0	0	0	0	0	2	0	2	0	4	2	3	0	4	3	5			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr16:87445930T>G	uc002fjz.1	-	12	2013	c.1986A>C	c.(1984-1986)CAA>CAC	p.Q662H	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.Q438H	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	662					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding	p.Q662H(1)		upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GCACACTTATTTGCACATTAT	0.532													127	84					0	0	0	0	G	87445930	G	G	87445930	3	3	187	1	0	0	0	0	1	0	0	0	17650	1838	64	5	871	5	ZCCHC14	16	87445930	Missense_Mutation	SNP	T	TCGA-CV-5979-01A-11D-1683-08		87445930	2908823	30	34703											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	6	9	15	11	2	1	2	1	2	0	0	2	3	2	3	4	4	2	2	4	4	0	1	rs11540652		TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	28					0	0	0	0	T	7577538	T	T	7577538	3	4	187	1	0	0	0	0	1	0	0	0	16448	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08		7577538	73617672	31	34704											
KRT14	3861	broad.mit.edu	37	chr17	39740135	39740135	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcgtccatctccacattGacatctccacccacctggcc	8	8	6	19	1	2	1	0	1	2	0	5	1	3	1	6	1	1	1	6	1	0	1			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr17:39740135G>T	uc002hxf.1	-	4	865	c.804C>A	c.(802-804)GTC>GTA	p.V268V	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Silent_p.V268V	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	268	Rod.|Linker 12.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				TCTCCACATTGACATCTCCAC	0.567													31	44					1.75199e-13	2.18998e-13	1	0	T	39740135	T	T	39740135	2	4	187	1	0	0	0	0	0	0	0	1	8490	1277	45	2		2	KRT14	17	39740135	Silent	SNP	G	TCGA-CV-5979-01A-11D-1683-08	32162597	39740135	41455075	32	34705											
MRPL27	51264	broad.mit.edu	37	chr17	48447949	48447949	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcttagcaaggatgtaacTgcagagaaaacagaaacatt	17	7	11	6	0	0	2	0	0	0	2	0	4	0	3	0	2	5	4	0	2	6	3			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr17:48447949T>A	uc002iqq.2	-	2	72	c.41_splice	c.e2-1	p.V14_splice	MRPL27_uc002iqr.2_Splice_Site_p.V14_splice|EME1_uc002iqs.1_5'Flank	NM_016504	NP_057588	Q9P0M9	RM27_HUMAN	mitochondrial ribosomal protein L27						translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;1.73e-07)			AGGATGTAACTGCAGAGAAAA	0.498													5	147					0	0	0	0	A	48447949	A	A	48447949	5	1	187	1	0	0	0	0	0	0	1	0	9844	1594	55	5	419	5	MRPL27	17	48447949	Splice_Site	SNP	T	TCGA-CV-5979-01A-11D-1683-08	8707814	48447949	32747261	33	34706											
CDC42EP4	23580	broad.mit.edu	37	chr17	71282113	71282113	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgctcatcgaggagggggTcaggggaatgtggacccgcg	7	6	18	10	3	2	0	2	0	0	0	3	4	2	3	2	6	1	1	2	6	1	0			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr17:71282113T>C	uc002jjn.2	-	2	674	c.527A>G	c.(526-528)GAC>GGC	p.D176G	CDC42EP4_uc002jjo.2_Missense_Mutation_p.D176G|CDC42EP4_uc002jjp.1_Missense_Mutation_p.D106G	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	176					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			GAGGAGGGGGTCAGGGGAATG	0.657													25	28					0	0	0	0	C	71282113	C	C	71282113	3	2	187	1	0	0	0	0	1	0	0	0	3093	1667	58	5	547	5	CDC42EP4	17	71282113	Missense_Mutation	SNP	T	TCGA-CV-5979-01A-11D-1683-08	22834164	71282113	9913097	34	34707											
RNF213	57674	broad.mit.edu	37	chr17	78326742	78326742	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcttcactcttcacagggCtgtggcagtctgtccacatc	6	12	10	13	0	4	0	2	0	2	0	6	0	5	0	1	3	0	3	1	3	0	2			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr17:78326742C>A	uc002jyh.1	+	8	4748	c.4525C>A	c.(4525-4527)CTG>ATG	p.L1509M	uc002jyi.1_RNA|RNF213_uc010dhw.1_5'Flank	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CTTCACAGGGCTGTGGCAGTC	0.562													9	139					0.000673444	0.000734666	1	0	A	78326742	A	A	78326742	3	1	187	1	0	0	0	0	1	0	0	0	13542	796	28	4	10751	4	RNF213	17	78326742	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08	7044629	78326742	2868468	35	34708											
REXO1	57455	broad.mit.edu	37	chr19	1818781	1818781	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggtgcgggaaggggtagccGttctccttgagctggtcctg	4	10	18	9	2	1	1	0	1	1	0	3	2	2	2	3	5	3	3	3	5	2	3	rs138422554	by1000genomes	TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr19:1818781G>A	uc002lua.3	-	9	2921	c.2826C>T	c.(2824-2826)AAC>AAT	p.N942N	REXO1_uc010dsq.2_Silent_p.N251N|REXO1_uc010xgs.1_Translation_Start_Site|MIR1909_hsa-mir-1909|MI0008330_5'Flank|REXO1_uc010dsp.1_RNA	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	942						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGGTAGCCGTTCTCCTTGA	0.667													11	19					0	0	0	0	A	1818781	A	A	1818781	2	1	187	1	0	0	0	0	0	0	0	1	13306	1136	40	1		1	REXO1	19	1818781	Silent	SNP	G	TCGA-CV-5979-01A-11D-1683-08		1818781	57310202	36	34709											
ZNF414	84330	broad.mit.edu	37	chr19	8576734	8576734	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcgcgggcggctctcggTccagggccgggggtggcggc	1	4	22	14	7	1	0	0	0	1	0	3	0	2	0	3	9	0	1	3	9	0	0			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr19:8576734T>A	uc002mkf.2	-	5	759	c.641A>T	c.(640-642)GAC>GTC	p.D214V	ZNF414_uc002mke.3_Missense_Mutation_p.D214V|ZNF414_uc010dwf.2_Missense_Mutation_p.D203V	NM_032370	NP_115746	Q96IQ9	ZN414_HUMAN	zinc finger protein 414 isoform 2	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGGCTCTCGGTCCAGGGCCGG	0.746													5	3					0	0	0	0	A	8576734	A	A	8576734	3	1	187	1	0	0	0	0	1	0	0	0	17958	1667	58	5	561	5	ZNF414	19	8576734	Missense_Mutation	SNP	T	TCGA-CV-5979-01A-11D-1683-08	6757953	8576734	50552249	37	34710											
SGK2	10110	broad.mit.edu	37	chr20	42208658	42208658	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccccataaactgggatgAcctgtaccacaagaggctaa	14	6	9	12	0	0	2	0	1	0	1	0	3	0	3	4	2	3	2	4	2	5	3			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr20:42208658A>G	uc002xkv.2	+	11	1295	c.1076A>G	c.(1075-1077)GAC>GGC	p.D359G	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.D299G|SGK2_uc010ggm.2_Missense_Mutation_p.D299G|SGK2_uc002xks.2_Missense_Mutation_p.D298G|SGK2_uc002xku.2_Missense_Mutation_p.D299G	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	359	AGC-kinase C-terminal.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity	p.D359G(1)		lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			AACTGGGATGACCTGTACCAC	0.383													19	28					0	0	0	0	G	42208658	G	G	42208658	3	3	187	1	0	0	0	0	1	0	0	0	14274	275	10	5	1118	5	SGK2	20	42208658	Missense_Mutation	SNP	A	TCGA-CV-5979-01A-11D-1683-08		42208658	20816862	38	34711											
TNFRSF6B	8771	broad.mit.edu	37	chr20	62328365	62328365	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgccactacacgcagttctGgaactacctagagcgctgcc	9	7	10	15	3	1	1	0	0	1	1	1	2	1	2	3	1	5	3	3	1	4	4			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr20:62328365G>A	uc002yfy.2	+	5	679	c.245G>A	c.(244-246)TGG>TAG	p.W82*	RTEL1_uc011abd.1_3'UTR|RTEL1_uc011abe.1_3'UTR|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_3'UTR|TNFRSF6B_uc002yfz.2_Nonsense_Mutation_p.W82*	NM_032945	NP_116563	O95407	TNF6B_HUMAN	tumor necrosis factor receptor superfamily,	82	TNFR-Cys 2.				anti-apoptosis|apoptosis	extracellular region|soluble fraction	protein binding|receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.66e-12)|all_epithelial(29;2.56e-13)|Lung NSC(23;1.06e-08)|all_lung(23;3.34e-08)		Epithelial(9;1.78e-08)|all cancers(9;7.89e-08)|OV - Ovarian serous cystadenocarcinoma(5;0.00504)			ACGCAGTTCTGGAACTACCTA	0.697													5	14					0	0	0	0	A	62328365	A	A	62328365	4	1	187	1	0	0	0	0	0	1	0	0	16364	1357	47	4	247	4	TNFRSF6B	20	62328365	Nonsense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08	20119707	62328365	697155	39	34712											
KRTAP10-9	386676	broad.mit.edu	37	chr21	46047662	46047662	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtctgctgtaagcctgtcTgctgcaaacccatctgctgt	6	13	9	13	0	3	0	0	0	3	0	3	0	3	0	2	0	6	5	2	0	2	1			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr21:46047662T>A	uc002zfp.3	+	1	623	c.574T>A	c.(574-576)TGC>AGC	p.C192S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	192	25 X 5 AA repeats of C-C-X(3).|19.					keratin filament					0						TAAGCCTGTCTGCTGCAAACC	0.597													9	225					0	0	0	0	A	46047662	A	A	46047662	3	1	187	1	0	0	0	0	1	0	0	0	8555	1580	55	5	576	5	KRTAP10-9	21	46047662	Missense_Mutation	SNP	T	TCGA-CV-5979-01A-11D-1683-08		46047662	2082233	40	34713											
IL3RA	3563	broad.mit.edu	37	chrX	1484134	1484134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgagcgcctggagcacccCccagcgcttcggtgagtggg	5	7	15	14	3	0	2	0	2	0	0	1	3	0	3	4	3	3	2	4	3	0	2			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chrX:1484134C>T	uc004cps.2	+	9	1212	c.863C>T	c.(862-864)CCC>CTC	p.P288L	IL3RA_uc011mhd.1_Missense_Mutation_p.P210L	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	288	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TGGAGCACCCCCCAGCGCTTC	0.373													15	36					0	0	0	0	T	1484134	T	T	1484134	3	4	187	1	0	0	0	0	1	0	0	0	7734	623	22	4	893	4	IL3RA	23	1484134	Missense_Mutation	SNP	C	TCGA-CV-5979-01A-11D-1683-08		1484134	153786426	41	34714											
BEND2	139105	broad.mit.edu	37	chrX	18195875	18195875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tactctgacatttctttttgGatcaccaagatagcctttaa	11	16	5	9	0	3	2	1	1	2	1	3	3	3	3	2	1	2	0	2	1	4	7			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chrX:18195875G>A	uc004cyj.3	-	10	1598	c.1444C>T	c.(1444-1446)CCA>TCA	p.P482S	BEND2_uc010nfb.2_Missense_Mutation_p.P391S	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	482										ovary(3)|kidney(1)|central_nervous_system(1)	5						TTTCTTTTTGGATCACCAAGA	0.378													14	107					0	0	0	0	A	18195875	A	A	18195875	3	1	187	1	0	0	0	0	1	0	0	0	1400	1174	41	2	1001	2	BEND2	23	18195875	Missense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08	16711741	18195875	137074685	42	34715											
TCEAL3	85012	broad.mit.edu	37	chrX	102864204	102864204	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagccaggaaaagcagggcaGgtccgaaggtgagggcaagc	14	2	17	8	1	0	1	0	1	0	0	1	3	1	2	2	5	3	3	2	5	5	0			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chrX:102864204G>A	uc004ekq.2	+	3	474	c.212G>A	c.(211-213)AGG>AAG	p.R71K	TCEAL3_uc004ekr.2_Missense_Mutation_p.R71K	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	71	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AAGCAGGGCAGGTCCGAAGGT	0.398													3	67					0	0	0	0	A	102864204	A	A	102864204	3	1	187	1	0	0	0	0	1	0	0	0	15738	1000	35	4	214	4	TCEAL3	23	102864204	Missense_Mutation	SNP	G	TCGA-CV-5979-01A-11D-1683-08	84668329	102864204	52406356	43	34716											
MEGF6	1953	broad.mit.edu	37	chr1	3422007	3422007	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcctgacagcgctcgccccGgaagccagccttgcaggagc	7	5	13	16	3	0	1	0	1	0	0	1	3	0	3	5	2	6	2	5	2	1	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:3422007G>A	uc001akl.2	-	16	2259	c.2032C>T	c.(2032-2034)CGG>TGG	p.R678W	MEGF6_uc001akk.2_Missense_Mutation_p.R573W	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	678						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CGCTCGCCCCGGAAGCCAGCC	0.697													3	9					0	0	0	0	A	3422007	A	A	3422007	3	1	188	1	0	0	0	0	1	0	0	0	9515	1115	39	1	2681	1	MEGF6	1	3422007	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08		3422007	245828614	1	34717											
SPEN	23013	broad.mit.edu	37	chr1	16203028	16203028	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcaggagtcggtcaccaCattcatcccagtctagaaat	13	8	8	12	1	3	1	2	0	1	1	5	2	4	2	2	2	1	1	2	2	2	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:16203028C>T	uc001axk.1	+	3	940	c.736C>T	c.(736-738)CAT>TAT	p.H246Y	SPEN_uc010obp.1_Missense_Mutation_p.H205Y	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	246	Ser-rich.|Arg-rich.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TCGGTCACCACATTCATCCCA	0.542													30	30					0	0	0	0	T	16203028	T	T	16203028	3	4	188	1	0	0	0	0	1	0	0	0	15104	478	17	4	746	4	SPEN	1	16203028	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	12781021	16203028	233047593	2	34718											
HSPG2	3339	broad.mit.edu	37	chr1	22169404	22169404	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgatgtagatgggctgggcCagtcctggagctgtgggcac	6	9	17	9	1	0	1	0	0	0	1	2	3	1	2	2	4	1	4	2	4	1	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:22169404C>T	uc001bfj.2	-	67	8809	c.8769G>A	c.(8767-8769)CTG>CTA	p.L2923L	HSPG2_uc009vqd.2_Silent_p.L2924L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2923	Ig-like C2-type 14.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGGGCTGGGCCAGTCCTGGAG	0.637													6	54					0	0	0	0	T	22169404	T	T	22169404	2	4	188	1	0	0	0	0	0	0	0	1	7469	581	21	4		4	HSPG2	1	22169404	Silent	SNP	C	TCGA-CV-6003-01A-11D-1683-08	5966376	22169404	227081217	3	34719											
TCEA3	6920	broad.mit.edu	37	chr1	23724057	23724057	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatcttcgatttctgatgcCatcttgtcacagttgactcc	7	16	7	11	1	4	3	1	3	3	0	6	4	5	3	2	0	1	1	2	0	0	4			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:23724057C>T	uc001bgx.1	-	7	780	c.645G>A	c.(643-645)ATG>ATA	p.M215I	TCEA3_uc009vqn.1_Missense_Mutation_p.M194I	NM_003196	NP_003187	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	215	TFIIS central.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		TTTCTGATGCCATCTTGTCAC	0.498													8	45					0	0	0	0	T	23724057	T	T	23724057	3	4	188	1	0	0	0	0	1	0	0	0	15735	594	21	4	421	4	TCEA3	1	23724057	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	1554653	23724057	225526564	4	34720											
GRHL3	57822	broad.mit.edu	37	chr1	24663602	24663602	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatatcctgaaaacctcccCggaacccccatgtccagagg	12	6	8	15	1	0	3	0	1	0	2	3	4	3	4	7	2	2	0	7	2	4	1	rs149044763	by1000genomes	TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:24663602C>T	uc001biy.2	+	5	708	c.662C>T	c.(661-663)CCG>CTG	p.P221L	GRHL3_uc001bix.2_Missense_Mutation_p.P216L|GRHL3_uc001biz.2_Missense_Mutation_p.P123L	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	216					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		AAAACCTCCCCGGAACCCCCA	0.547													5	25					0	0	0	0	T	24663602	T	T	24663602	3	4	188	1	0	0	0	0	1	0	0	0	6804	652	23	1	701	1	GRHL3	1	24663602	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	939545	24663602	224587019	5	34721											
TFAP2E	339488	broad.mit.edu	37	chr1	36060122	36060122	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actttagcctcatcacccatGgcttcggtgggcctgccatc	6	11	9	15	1	2	0	2	0	0	0	4	0	2	0	4	3	2	1	4	3	1	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:36060122G>T	uc010ohy.1	+	7	1382	c.1174G>T	c.(1174-1176)GGC>TGC	p.G392C	PSMB2_uc001bzd.1_Intron	NM_178548	NP_848643	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating	392	H-S-H (helix-span-helix), dimerization.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CATCACCCATGGCTTCGGTGG	0.587													22	26					5.26018e-13	5.71364e-13	1	0	T	36060122	T	T	36060122	3	4	188	1	0	0	0	0	1	0	0	0	15857	1348	47	4	1200	4	TFAP2E	1	36060122	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	11396520	36060122	213190499	6	34722											
GUCA2A	2980	broad.mit.edu	37	chr1	42628622	42628622	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacagatttcacatgtgccCgggtcctcagcgatttcctc	7	11	9	14	2	2	1	2	0	0	1	5	2	4	1	3	1	2	1	3	1	0	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:42628622C>T	uc001chd.1	-	3	315	c.303G>A	c.(301-303)CCG>CCA	p.P101P		NM_033553	NP_291031	Q02747	GUC2A_HUMAN	guanylate cyclase activator 2A precursor	101					signal transduction	extracellular region	guanylate cyclase activator activity|hormone activity			pancreas(1)	1	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CACATGTGCCCGGGTCCTCAG	0.617													10	46					0	0	0	0	T	42628622	T	T	42628622	2	4	188	1	0	0	0	0	0	0	0	1	6930	639	23	1		1	GUCA2A	1	42628622	Silent	SNP	C	TCGA-CV-6003-01A-11D-1683-08	6568500	42628622	206621999	7	34723											
CNN3	1266	broad.mit.edu	37	chr1	95367290	95367290	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaacgtcttgtttgtttttCtgcatacttaactccaatgt	10	18	5	8	1	2	0	0	0	2	0	3	0	3	0	1	0	4	3	1	0	5	6			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:95367290C>G	uc010otw.1	-	6	518	c.436G>C	c.(436-438)GAA>CAA	p.E146Q	CNN3_uc010otv.1_Missense_Mutation_p.E105Q|CNN3_uc001dqz.3_Missense_Mutation_p.E146Q|CNN3_uc010otx.1_Missense_Mutation_p.E100Q	NM_001839	NP_001830	Q15417	CNN3_HUMAN	calponin 3	146					actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		GTTTGTTTTTCTGCATACTTA	0.363													8	26					0	0	0	0	G	95367290	G	G	95367290	3	3	188	1	0	0	0	0	1	0	0	0	3626	922	32	2	565	2	CNN3	1	95367290	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	52738668	95367290	153883331	8	34724											
CLCC1	23155	broad.mit.edu	37	chr1	109479802	109479803	+	Frame_Shift_Del	DEL	TC	-	-																															tctgaaatctcaagtcaacaTctctctctctcaaaatctct																										TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:109479802_109479803delTC	uc001dwe.1	-	10	1371_1372	c.1279_1280delGA	c.(1279-1281)GATfs	p.D427fs	AKNAD1_uc010ovb.1_Intron|CLCC1_uc001dwf.1_Frame_Shift_Del_p.D427fs|CLCC1_uc001dwg.1_Frame_Shift_Del_p.D377fs|CLCC1_uc009wes.1_Frame_Shift_Del_p.D306fs|CLCC1_uc009wet.1_Frame_Shift_Del_p.D242fs	NM_001048210	NP_001041675	Q96S66	CLCC1_HUMAN	Mid-1-related chloride channel 1 isoform 1	427						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				liver(1)	1		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		CAAGTCAACATCTCTCTCTCTC	0.52													---	---	---								-	109479803	-	-	109479802	7	5	188	1	0	1	0	1	0	0	0	0	3475	1435	50	0	383	0	CLCC1	1	109479802	Frame_Shift_Del	DEL	TC	TCGA-CV-6003-01A-11D-1683-08	14112512	109479802	139770819	9	34725											
NOTCH2	4853	broad.mit.edu	37	chr1	120539834	120539834	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcattgacatcagtctcAcatttctgccctgtgaagcc	9	12	6	14	0	4	2	3	2	2	0	5	2	4	2	2	0	2	0	2	0	1	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:120539834A>T	uc001eik.2	-	4	793	c.537T>A	c.(535-537)TGT>TGA	p.C179*	NOTCH2_uc001eil.2_Nonsense_Mutation_p.C179*|NOTCH2_uc001eim.3_Nonsense_Mutation_p.C96*	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	179	Extracellular (Potential).|EGF-like 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATCAGTCTCACATTTCTGCC	0.552			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				18	37					0	0	0	0	T	120539834	T	T	120539834	4	4	188	1	0	0	0	0	0	1	0	0	10602	157	6	5	7002	5	NOTCH2	1	120539834	Nonsense_Mutation	SNP	A	TCGA-CV-6003-01A-11D-1683-08	11060032	120539834	128710787	10	34726											
RNASEL	6041	broad.mit.edu	37	chr1	182555479	182555479	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatcctcctttgtctttcGcctcaaattcacatttgctc	6	18	4	13	1	3	1	2	1	1	0	7	1	5	1	3	0	1	1	3	0	1	5			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:182555479G>A	uc001gpj.1	-	1	630	c.463C>T	c.(463-465)CGA>TGA	p.R155*	RNASEL_uc009wxz.1_Nonsense_Mutation_p.R155*|RNASEL_uc001gpk.2_Nonsense_Mutation_p.R155*|RNASEL_uc009wya.1_Nonsense_Mutation_p.R155*	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	155					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						TTTGTCTTTCGCCTCAAATTC	0.468									Hereditary_Prostate_Cancer				3	23					0	0	0	0	A	182555479	A	A	182555479	4	1	188	1	0	0	0	0	0	1	0	0	13481	1095	38	1	1786	1	RNASEL	1	182555479	Nonsense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	62015645	182555479	66695142	11	34727											
RBM34	23029	broad.mit.edu	37	chr1	235301488	235301488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatcaggatgaattttacGtctacaccaaaaaaaaaaaa	20	9	5	7	1	2	2	1	2	1	0	2	3	2	3	1	1	2	0	1	1	9	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:235301488G>A	uc001hwn.2	-	7	733	c.703C>T	c.(703-705)CGT>TGT	p.R235C	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	235	RRM 1.					nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			TGAATTTTACGTCTACACCAA	0.333													5	10					0	0	0	0	A	235301488	A	A	235301488	3	1	188	1	0	0	0	0	1	0	0	0	13196	1159	40	1	609	1	RBM34	1	235301488	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	52746009	235301488	13949133	12	34728											
FMN2	56776	broad.mit.edu	37	chr1	240256066	240256066	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctccagctccagctccagcaAcagcagcagcagcagcagct	11	4	9	17	0	0	0	0	0	0	0	3	0	3	0	3	0	10	9	3	0	1	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr1:240256066A>G	uc010pyd.1	+	1	882	c.657A>G	c.(655-657)CAA>CAG	p.Q219Q	FMN2_uc010pye.1_Silent_p.Q219Q	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	219	Potential.|Gln-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			agctccagcaacagcagcagc	0.468													6	6					0	0	0	0	G	240256066	G	G	240256066	2	3	188	1	0	0	0	0	0	0	0	1	5982	40	2	5		5	FMN2	1	240256066	Silent	SNP	A	TCGA-CV-6003-01A-11D-1683-08	4954578	240256066	8994555	13	34729											
MTA3	57504	broad.mit.edu	37	chr2	42836614	42836614	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtagaagaaattgaggaagaAtctgaaacaacagttgaggc	18	7	12	4	0	1	6	0	3	1	3	1	7	1	7	0	2	2	2	0	2	7	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr2:42836614A>C	uc002rso.1	+	5	709	c.39A>C	c.(37-39)GAA>GAC	p.E13D	MTA3_uc002rsp.1_Missense_Mutation_p.E13D|MTA3_uc002rsq.2_Missense_Mutation_p.E69D|MTA3_uc002rsr.2_Missense_Mutation_p.E69D	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	69	BAH.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TTGAGGAAGAATCTGAAACAA	0.343													5	33					0	0	0	0	C	42836614	C	C	42836614	3	2	188	1	0	0	0	0	1	0	0	0	9963	98	4	5	221	5	MTA3	2	42836614	Missense_Mutation	SNP	A	TCGA-CV-6003-01A-11D-1683-08		42836614	200362759	14	34730											
HS6ST1	9394	broad.mit.edu	37	chr2	129026288	129026288	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgtgcagcccgaccagtcCgtgccctcgtagcagggcgg	6	5	15	15	5	0	0	0	0	0	0	2	1	1	0	4	2	5	3	4	2	1	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr2:129026288C>T	uc002tpt.3	-	2	718	c.684G>A	c.(682-684)ACG>ACA	p.T228T		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	228	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		CCGACCAGTCCGTGCCCTCGT	0.662													6	62					0	0	0	0	T	129026288	T	T	129026288	2	4	188	1	0	0	0	0	0	0	0	1	7409	639	23	1		1	HS6ST1	2	129026288	Silent	SNP	C	TCGA-CV-6003-01A-11D-1683-08	86189674	129026288	114173085	15	34731											
SCN1A	6323	broad.mit.edu	37	chr2	166908262	166908262	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatgacttccagtcaaactCaaagacagtttcatttataa	16	13	4	8	0	3	2	3	1	0	1	4	2	4	2	1	0	1	1	1	0	5	6			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr2:166908262C>G	uc010zcz.1	-	6	949	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	SCN1A_uc002udo.3_Missense_Mutation_p.E180Q|SCN1A_uc010fpk.2_Missense_Mutation_p.E180Q	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	311	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CAGTCAAACTCAAAGACAGTT	0.234													4	21					0	0	0	0	G	166908262	G	G	166908262	3	3	188	1	0	0	0	0	1	0	0	0	13979	835	29	2	5182	2	SCN1A	2	166908262	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	37881974	166908262	76291111	16	34732											
TTN	7273	broad.mit.edu	37	chr2	179417913	179417913	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaatatattttcctgtatcaTtgcgagtaacttgaggaatg	12	15	9	5	1	1	1	1	1	0	0	2	4	2	2	1	1	2	2	1	1	6	8			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr2:179417913T>C	uc010zfg.1	-	284	82234	c.82010A>G	c.(82009-82011)AAT>AGT	p.N27337S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N21032S|TTN_uc010zfi.1_Missense_Mutation_p.N20965S|TTN_uc010zfj.1_Missense_Mutation_p.N20840S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28264							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTGTATCATTGCGAGTAAC	0.408													8	81					0	0	0	0	C	179417913	C	C	179417913	3	2	188	1	0	0	0	0	1	0	0	0	16803	1493	52	5	18377	5	TTN	2	179417913	Missense_Mutation	SNP	T	TCGA-CV-6003-01A-11D-1683-08	12509651	179417913	63781460	17	34733											
CCDC141	285025	broad.mit.edu	37	chr2	179730517	179730517	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttatctcgtctctcatggCgcagtactccacactacggg	8	12	8	13	3	3	0	1	0	2	0	6	0	4	0	1	2	2	2	1	2	3	4	rs139607358	byFrequency	TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr2:179730517C>T	uc002unf.1	-	7	1033	c.976G>A	c.(976-978)GCC>ACC	p.A326T		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	326	Potential.						protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TCTCTCATGGCGCAGTACTCC	0.532													45	192					0	0	0	0	T	179730517	T	T	179730517	3	4	188	1	0	0	0	0	1	0	0	0	2787	768	27	1	1679	1	CCDC141	2	179730517	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	312604	179730517	63468856	18	34734											
ZNF804A	91752	broad.mit.edu	37	chr2	185802876	185802876	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgatcccaccacatctgTctgtgtagctagtgccccaa	10	10	7	14	0	2	1	0	1	2	0	3	1	3	1	4	0	2	2	4	0	4	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr2:185802876T>C	uc002uph.2	+	4	3347	c.2753T>C	c.(2752-2754)GTC>GCC	p.V918A		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	918						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						ACCACATCTGTCTGTGTAGCT	0.388													11	64					0	0	0	0	C	185802876	C	C	185802876	3	2	188	1	0	0	0	0	1	0	0	0	18237	1667	58	5	2767	5	ZNF804A	2	185802876	Missense_Mutation	SNP	T	TCGA-CV-6003-01A-11D-1683-08	6072359	185802876	57396497	19	34735											
CPS1	1373	broad.mit.edu	37	chr2	211471538	211471538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtacttcaatcaatgttgttCgccacttgggcattgtgggt	7	15	11	8	1	2	0	2	0	0	0	3	0	2	0	1	2	1	4	1	2	3	6	rs147443001		TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr2:211471538C>T	uc002vee.3	+	18	2197	c.2065C>T	c.(2065-2067)CGC>TGC	p.R689C	CPS1_uc010fur.2_Missense_Mutation_p.R695C|CPS1_uc010fus.2_Missense_Mutation_p.R238C	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	689	ATP-grasp 1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CAATGTTGTTCGCCACTTGGG	0.468													10	48					0	0	0	0	T	211471538	T	T	211471538	3	4	188	1	0	0	0	0	1	0	0	0	3838	884	31	1	2157	1	CPS1	2	211471538	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	25668662	211471538	31727835	20	34736											
BRPF1	7862	broad.mit.edu	37	chr3	9785382	9785382	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcaagcagagtgtgggccGctcacggcgtgcaaagatga	11	5	15	10	3	1	3	1	1	0	2	1	3	1	3	1	2	3	4	1	2	2	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr3:9785382G>A	uc003bse.2	+	8	2813	c.2414G>A	c.(2413-2415)CGC>CAC	p.R805H	BRPF1_uc003bsf.2_Missense_Mutation_p.R811H|BRPF1_uc003bsg.2_Missense_Mutation_p.R804H|BRPF1_uc011ati.1_Missense_Mutation_p.R805H	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	805	Required for RUNX1 and RUNX2 transcriptional activation.|Interaction with MEAF6 and ING5.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					AGTGTGGGCCGCTCACGGCGT	0.592													13	8					0	0	0	0	A	9785382	A	A	9785382	3	1	188	1	0	0	0	0	1	0	0	0	1525	1087	38	1	2458	1	BRPF1	3	9785382	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08		9785382	188237048	21	34737											
RBM5	10181	broad.mit.edu	37	chr3	50144226	50144227	+	Frame_Shift_Del	DEL	AC	-	-																															tctcagctgcttcagatattAcagagtctccatcctccttt																										TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr3:50144226_50144227delAC	uc003cyg.2	+	11	1030_1031	c.882_883delAC	c.(880-885)TTACAGfs	p.L294fs	RBM5_uc011bdj.1_Frame_Shift_Del_p.L238fs|RBM5_uc011bdk.1_Frame_Shift_Del_p.L122fs	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	294_295	RRM 2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TTCAGATATTACAGAGTCTCCA	0.396													---	---	---								-	50144227	-	-	50144226	7	5	188	1	0	1	0	1	0	0	0	0	13208	388	14	0	920	0	RBM5	3	50144226	Frame_Shift_Del	DEL	AC	TCGA-CV-6003-01A-11D-1683-08	40358844	50144226	147878204	22	34738											
ABTB1	80325	broad.mit.edu	37	chr3	127394943	127394943	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaggcgggattactatgaCgacttcttgcagcggtgagc	9	9	15	8	3	1	2	0	2	1	0	1	5	1	4	0	4	4	1	0	4	2	4	rs75647091	by1000genomes	TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr3:127394943C>G	uc003ejt.2	+	4	394	c.306C>G	c.(304-306)GAC>GAG	p.D102E	ABTB1_uc003ejr.2_5'UTR|ABTB1_uc003ejs.2_Missense_Mutation_p.D77E|ABTB1_uc003eju.2_5'UTR|ABTB1_uc010hsm.2_5'Flank	NM_172027	NP_742024	Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	102						cytoplasm|nucleolus|plasma membrane	translation elongation factor activity				0						ATTACTATGACGACTTCTTGC	0.642													31	18					0	0	0	0	G	127394943	G	G	127394943	3	3	188	1	0	0	0	0	1	0	0	0	102	535	19	3	320	3	ABTB1	3	127394943	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	77250717	127394943	70627487	23	34739											
SENP2	59343	broad.mit.edu	37	chr3	185347618	185347618	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgtgggaaatccttcatCagcagttgctgtgagaaaac	11	11	12	7	0	2	1	2	1	0	1	3	3	3	2	1	2	3	3	1	2	3	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr3:185347618C>T	uc003fpn.2	+	17	1927	c.1756C>T	c.(1756-1758)CAG>TAG	p.Q586*	SENP2_uc011brv.1_Nonsense_Mutation_p.Q576*|SENP2_uc011brw.1_Nonsense_Mutation_p.Q399*	NM_021627	NP_067640	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific protease 2	586					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity				0	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			AATCCTTCATCAGCAGTTGCT	0.468													9	54					0	0	0	0	T	185347618	T	T	185347618	4	4	188	1	0	0	0	0	0	1	0	0	14112	827	29	2	1822	2	SENP2	3	185347618	Nonsense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	57952675	185347618	12674812	24	34740											
TP63	8626	broad.mit.edu	37	chr3	189526228	189526229	+	Frame_Shift_Ins	INS	-	A	A																															ctctctctccatcacccgccINSatcccctccaacaccgacta																										TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr3:189526228_189526229insA	uc003fry.2	+	4	581_582	c.492_493insA	c.(490-495)GCCATCfs	p.A164fs	TP63_uc003frx.2_Frame_Shift_Ins_p.A164fs|TP63_uc003frz.2_Frame_Shift_Ins_p.A164fs|TP63_uc010hzc.1_Frame_Shift_Ins_p.A164fs|TP63_uc003fsa.2_Frame_Shift_Ins_p.A70fs|TP63_uc003fsb.2_Frame_Shift_Ins_p.A70fs|TP63_uc003fsc.2_Frame_Shift_Ins_p.A70fs|TP63_uc003fsd.2_Frame_Shift_Ins_p.A70fs|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_Frame_Shift_Ins_p.A45fs	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	164_165					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CATCACCCGCCATCCCCTCCAA	0.644									Hay-Wells_syndrome	HNSCC(45;0.13)			---	---	---								A	189526229	A	A	189526228	7	5	188	1	0	1	1	0	0	0	0	0	16459	581	21	0	552	0	TP63	3	189526228	Frame_Shift_Ins	INS	-	TCGA-CV-6003-01A-11D-1683-08	4178610	189526228	8496202	25	34741											
FAT4	79633	broad.mit.edu	37	chr4	126411278	126411278	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggactgtgcctcccaccCgtgccagaatggtggcagct	6	8	14	13	1	0	1	0	0	0	1	1	2	1	2	4	4	3	2	4	4	1	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr4:126411278C>T	uc003ifj.3	+	17	13301	c.13301C>T	c.(13300-13302)CCG>CTG	p.P4434L	FAT4_uc011cgp.1_Missense_Mutation_p.P2675L|FAT4_uc003ifi.1_Missense_Mutation_p.P1911L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4434	EGF-like 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GCCTCCCACCCGTGCCAGAAT	0.607													45	49					0	0	0	0	T	126411278	T	T	126411278	3	4	188	1	0	0	0	0	1	0	0	0	5724	652	23	1	13367	1	FAT4	4	126411278	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08		126411278	64742998	26	34742											
CDH9	1007	broad.mit.edu	37	chr5	26885757	26885757	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acacagagtagaatcgcaacGagagctcccgtgctcaggcc	12	5	11	13	3	1	3	1	0	0	3	3	4	2	3	2	1	3	4	2	1	3	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr5:26885757G>A	uc003jgs.1	-	11	2017	c.1848C>T	c.(1846-1848)CTC>CTT	p.L616L	CDH9_uc011cnv.1_Silent_p.L209L	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	616	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GAATCGCAACGAGAGCTCCCG	0.512													8	13					0	0	0	0	A	26885757	A	A	26885757	2	1	188	1	0	0	0	0	0	0	0	1	3132	1045	37	1		1	CDH9	5	26885757	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08		26885757	154029503	27	34743											
NNT	23530	broad.mit.edu	37	chr5	43616103	43616103	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacagttctggcaatggacCaggttccaagagtcacaatt	12	10	9	10	0	2	1	1	0	1	1	3	2	3	2	2	3	1	3	2	3	4	4			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr5:43616103C>G	uc003joe.2	+	4	790	c.535C>G	c.(535-537)CAG>GAG	p.Q179E	NNT_uc003jof.2_Missense_Mutation_p.Q179E	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	179	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	GGCAATGGACCAGGTTCCAAG	0.423													8	73					0	0	0	0	G	43616103	G	G	43616103	3	3	188	1	0	0	0	0	1	0	0	0	10564	595	21	4	545	4	NNT	5	43616103	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	16730346	43616103	137299157	28	34744											
PCDHA5	56143	broad.mit.edu	37	chr5	140202723	140202723	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgacaacgctccggcgttcGcgcagccccagtataccgtg	8	6	11	16	7	0	0	0	0	0	0	2	1	1	0	4	1	3	4	4	1	3	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr5:140202723G>A	uc003lhl.2	+	1	1363	c.1363G>A	c.(1363-1365)GCG>ACG	p.A455T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.A455T|PCDHA5_uc003lhj.1_Missense_Mutation_p.A455T	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	455	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCGGCGTTCGCGCAGCCCCA	0.677													12	40					0	0	0	0	A	140202723	A	A	140202723	3	1	188	1	0	0	0	0	1	0	0	0	11581	1087	38	1	1365	1	PCDHA5	5	140202723	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	96586620	140202723	40712537	29	34745											
PCDHA13	56136	broad.mit.edu	37	chr5	140263856	140263856	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacggcaacggtgctgttgtCgctggtggagagcggccaag	7	7	17	10	4	0	1	0	0	0	1	1	2	0	1	1	5	3	4	1	5	2	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr5:140263856C>T	uc003lif.2	+	1	2003	c.2003C>T	c.(2002-2004)TCG>TTG	p.S668L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.S668L|PCDHA13_uc003lid.2_Missense_Mutation_p.S668L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	668	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCTGTTGTCGCTGGTGGAG	0.672													24	22					0	0	0	0	T	140263856	T	T	140263856	3	4	188	1	0	0	0	0	1	0	0	0	11577	893	31	1	2005	1	PCDHA13	5	140263856	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	61133	140263856	40651404	30	34746											
PCDHGB1	56104	broad.mit.edu	37	chr5	140730444	140730444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaacatcagagctctcatcGcttaatcctgactgccatgg	10	10	9	12	1	2	2	2	1	1	1	5	3	3	3	2	2	3	2	2	2	2	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr5:140730444G>A	uc003ljo.1	+	1	617	c.617G>A	c.(616-618)CGC>CAC	p.R206H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.R206H	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	206	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTCTCATCGCTTAATCCTG	0.493													20	24					0	0	0	0	A	140730444	A	A	140730444	3	1	188	1	0	0	0	0	1	0	0	0	11616	1087	38	1	619	1	PCDHGB1	5	140730444	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	466588	140730444	40184816	31	34747											
GABRA1	2554	broad.mit.edu	37	chr5	161302579	161302579	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccttaaggctgacagtgagaGctgaatgtccgatgcatttg	10	11	12	8	1	0	3	0	3	0	1	1	5	1	3	2	1	2	3	2	1	2	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr5:161302579G>A	uc010jiw.2	+	7	958	c.490G>A	c.(490-492)GCT>ACT	p.A164T	GABRA1_uc010jix.2_Missense_Mutation_p.A164T|GABRA1_uc010jiy.2_Missense_Mutation_p.A164T|GABRA1_uc003lyx.3_Missense_Mutation_p.A164T|GABRA1_uc010jiz.2_Missense_Mutation_p.A164T|GABRA1_uc010jja.2_Missense_Mutation_p.A164T|GABRA1_uc010jjb.2_Missense_Mutation_p.A164T	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	164	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	GACAGTGAGAGCTGAATGTCC	0.373													20	50					0	0	0	0	A	161302579	A	A	161302579	3	1	188	1	0	0	0	0	1	0	0	0	6194	971	34	4	508	4	GABRA1	5	161302579	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	20572135	161302579	19612681	32	34748											
FGFR4	2264	broad.mit.edu	37	chr5	176523713	176523713	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgggagggacatcggatGgaccgacccccacactgccc	8	4	13	16	3	0	0	0	0	0	0	1	5	0	4	4	4	2	0	4	4	0	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr5:176523713G>A	uc003mfl.2	+	16	2291	c.2124G>A	c.(2122-2124)ATG>ATA	p.M708I	FGFR4_uc003mfm.2_Missense_Mutation_p.M708I|FGFR4_uc011dfu.1_Missense_Mutation_p.M640I|FGFR4_uc003mfo.2_Missense_Mutation_p.M668I	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	708	Protein kinase.|Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GACATCGGATGGACCGACCCC	0.657										TSP Lung(9;0.080)			4	20					0	0	0	0	A	176523713	A	A	176523713	3	1	188	1	0	0	0	0	1	0	0	0	5900	1348	47	4	2252	4	FGFR4	5	176523713	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	15221134	176523713	4391547	33	34749											
NSD1	64324	broad.mit.edu	37	chr5	176719035	176719035	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcaggacccagggtgaaatCacaaaggagcgagaagatga	16	3	14	8	2	1	4	1	2	0	2	1	7	1	6	1	3	1	1	1	3	3	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr5:176719035C>G	uc003mfr.3	+	22	6477	c.6339C>G	c.(6337-6339)ATC>ATG	p.I2113M	NSD1_uc003mft.3_Missense_Mutation_p.I1844M|NSD1_uc011dfx.1_Missense_Mutation_p.I1761M	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2113					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGGGTGAAATCACAAAGGAGC	0.483			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			6	8					0	0	0	0	G	176719035	G	G	176719035	3	3	188	1	0	0	0	0	1	0	0	0	10723	816	29	2	6421	2	NSD1	5	176719035	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	195322	176719035	4196225	34	34750											
BTNL8	79908	broad.mit.edu	37	chr5	180338567	180338567	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcatatcctgttccatgcGgcatgctcatctgagccgag	8	10	11	12	2	2	1	1	1	1	0	4	3	4	1	3	1	4	4	3	1	1	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr5:180338567G>A	uc003mmp.2	+	3	860	c.626G>A	c.(625-627)CGG>CAG	p.R209Q	BTNL8_uc003mmq.2_Missense_Mutation_p.R209Q|BTNL8_uc011dhg.1_Missense_Mutation_p.R84Q|BTNL8_uc010jll.2_Missense_Mutation_p.R209Q|BTNL8_uc010jlm.2_Missense_Mutation_p.R93Q|BTNL8_uc011dhh.1_Missense_Mutation_p.R25Q	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	209	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTTCCATGCGGCATGCTCAT	0.547													23	27					0	0	0	0	A	180338567	A	A	180338567	3	1	188	1	0	0	0	0	1	0	0	0	1572	1116	39	1	662	1	BTNL8	5	180338567	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	3619532	180338567	576693	35	34751											
MCHR2	84539	broad.mit.edu	37	chr6	100382357	100382357	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	accaaaatcaagggtagaggGaaaaaaaaagttgttatcgt	19	8	10	4	1	1	1	1	0	0	1	2	2	1	2	1	2	0	3	1	2	9	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr6:100382357G>T	uc003pqh.1	-	5	939	c.624C>A	c.(622-624)TTC>TTA	p.F208L	MCHR2_uc003pqi.1_Missense_Mutation_p.F208L	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	208	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		AGGGTAGAGGGAAAAAAAAAG	0.284													43	26					3.54909e-21	3.95739e-21	1	0	T	100382357	T	T	100382357	3	4	188	1	0	0	0	0	1	0	0	0	9436	1165	41	2	406	2	MCHR2	6	100382357	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08		100382357	70732710	36	34752											
MYCT1	80177	broad.mit.edu	37	chr6	153019042	153019042	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acacttatttccttttatgcGaacacaagtatatgaggggt	12	14	8	7	1	0	1	0	1	0	0	1	2	1	1	1	2	2	1	1	2	6	6			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr6:153019042G>A	uc003qpd.3	+	1	13	c.5G>A	c.(4-6)CGA>CAA	p.R2Q	MYCT1_uc010kjc.1_Missense_Mutation_p.R2Q|MYCT1_uc003qpc.3_Missense_Mutation_p.R2Q	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	2						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		CCTTTTATGCGAACACAAGTA	0.323													28	11					0	0	0	0	A	153019042	A	A	153019042	3	1	188	1	0	0	0	0	1	0	0	0	10075	1058	37	1	7	1	MYCT1	6	153019042	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	52636685	153019042	18096025	37	34753											
RBAK	57786	broad.mit.edu	37	chr7	5097370	5097370	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggagcagggagaggagccGtggataatgggaggtgaatt	11	8	19	3	1	0	2	0	1	0	1	0	7	0	6	1	6	2	1	1	6	2	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr7:5097370G>A	uc010kss.1	+	5	522	c.198G>A	c.(196-198)CCG>CCA	p.P66P	LOC389458_uc003snr.2_Silent_p.P66P|RBAK_uc003sns.1_Silent_p.P66P	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	66	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		GAGAGGAGCCGTGGATAATGG	0.453													19	65					0	0	0	0	A	5097370	A	A	5097370	2	1	188	1	0	0	0	0	0	0	0	1	13165	1132	40	1		1	RBAK	7	5097370	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08		5097370	154041293	38	34754											
CHN2	1124	broad.mit.edu	37	chr7	29552210	29552210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgaaaaagacaatttcatGaatgcagaaaatctggggat	19	9	9	4	0	2	4	1	2	1	2	2	5	2	5	0	2	1	1	0	2	7	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr7:29552210G>A	uc003szz.2	+	13	1703	c.1266G>A	c.(1264-1266)ATG>ATA	p.M422I	CHN2_uc011jzs.1_Missense_Mutation_p.M497I|CHN2_uc010kva.2_3'UTR|CHN2_uc010kvb.2_RNA|CHN2_uc010kvc.2_Missense_Mutation_p.M387I|CHN2_uc011jzt.1_Missense_Mutation_p.M435I|CHN2_uc010kvd.2_Missense_Mutation_p.M278I|CHN2_uc011jzu.1_Missense_Mutation_p.M407I|CHN2_uc010kvg.2_Missense_Mutation_p.M240I|CHN2_uc010kvh.2_Missense_Mutation_p.M182I|CHN2_uc010kvi.2_Missense_Mutation_p.M214I|CHN2_uc010kve.2_3'UTR|CHN2_uc003taa.2_Missense_Mutation_p.M286I|CHN2_uc010kvf.2_Missense_Mutation_p.M228I|CHN2_uc010kvj.2_Missense_Mutation_p.M195I|CHN2_uc010kvk.2_Missense_Mutation_p.M97I|CHN2_uc010kvl.2_RNA|CHN2_uc010kvm.2_Missense_Mutation_p.M241I|CHN2_uc011jzv.1_Missense_Mutation_p.M215I	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	422	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						ACAATTTCATGAATGCAGAAA	0.423													18	55					0	0	0	0	A	29552210	A	A	29552210	3	1	188	1	0	0	0	0	1	0	0	0	3378	1290	45	2	1484	2	CHN2	7	29552210	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	24454840	29552210	129586453	39	34755											
FGL2	10875	broad.mit.edu	37	chr7	76826174	76826174	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcactgtccagcctccccCcatggtctccatgtcacagt	7	9	7	18	0	2	0	1	0	1	0	5	0	4	0	6	1	2	1	6	1	0	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr7:76826174C>T	uc003ugb.2	-	2	782	c.742G>A	c.(742-744)GGG>AGG	p.G248R	CCDC146_uc003ufz.1_Intron|CCDC146_uc003uga.2_Intron	NM_006682	NP_006673	Q14314	FGL2_HUMAN	fibrinogen-like 2 precursor	248	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			skin(2)	2						CAGCCTCCCCCCATGGTCTCC	0.493													39	66					0	0	0	0	T	76826174	T	T	76826174	3	4	188	1	0	0	0	0	1	0	0	0	5905	623	22	4	581	4	FGL2	7	76826174	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	47273964	76826174	82312489	40	34756											
HYAL4	23553	broad.mit.edu	37	chr7	123516945	123516945	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataaggaagatgtggaacgcGcccagttaccttcacttgaa	13	9	10	9	2	1	2	1	1	0	1	1	4	1	4	2	2	2	1	2	2	5	4	rs138391454	byFrequency	TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr7:123516945G>A	uc003vlc.2	+	5	1820	c.1182G>A	c.(1180-1182)GCG>GCA	p.A394A	HYAL4_uc011knz.1_3'UTR	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	394	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						TGTGGAACGCGCCCAGTTACC	0.507													27	28					0	0	0	0	A	123516945	A	A	123516945	2	1	188	1	0	0	0	0	0	0	0	1	7505	1074	38	1		1	HYAL4	7	123516945	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08	46690771	123516945	35621718	41	34757											
OR6B1	135946	broad.mit.edu	37	chr7	143701141	143701141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agttcattctggtgggattcCctgggagcttgagtatgcgg	6	13	15	7	1	2	1	1	1	1	0	3	3	3	3	1	4	2	3	1	4	1	5			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr7:143701141C>T	uc003wdt.1	+	1	52	c.52C>T	c.(52-54)CCT>TCT	p.P18S		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					GGTGGGATTCCCTGGGAGCTT	0.483													14	25					0	0	0	0	T	143701141	T	T	143701141	3	4	188	1	0	0	0	0	1	0	0	0	11241	623	22	4	54	4	OR6B1	7	143701141	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	20184196	143701141	15437522	42	34758											
ESRP1	54845	broad.mit.edu	37	chr8	95683890	95683890	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catggggttcacatggttttGaatcaccaggtaagaaagat	13	11	11	6	0	2	3	2	1	0	2	2	3	2	3	1	4	0	3	1	4	3	4			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr8:95683890G>C	uc003ygq.3	+	11	1626	c.1443G>C	c.(1441-1443)TTG>TTC	p.L481F	ESRP1_uc003ygr.3_Missense_Mutation_p.L481F|ESRP1_uc003ygs.3_Missense_Mutation_p.L481F|ESRP1_uc003ygt.3_Missense_Mutation_p.L481F|ESRP1_uc003ygu.3_Missense_Mutation_p.L481F|ESRP1_uc003ygv.2_Missense_Mutation_p.L321F|ESRP1_uc003ygw.2_Missense_Mutation_p.L321F	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	481	RRM 3.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						ACATGGTTTTGAATCACCAGG	0.383													5	23					0	0	0	0	C	95683890	C	C	95683890	3	2	188	1	0	0	0	0	1	0	0	0	5282	1281	45	2	1485	2	ESRP1	8	95683890	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08		95683890	50680132	43	34759											
DSCC1	79075	broad.mit.edu	37	chr8	120859281	120859281	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgggtcattatttcttcctCacttgcctgaatttgatcaa	8	18	6	9	0	4	2	3	2	1	0	5	2	5	2	2	1	1	0	2	1	3	6			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr8:120859281C>T	uc003yov.2	-	4	661	c.526G>A	c.(526-528)GAG>AAG	p.E176K		NM_024094	NP_076999	Q9BVC3	DCC1_HUMAN	defective in sister chromatid cohesion 1	176					DNA replication|maintenance of mitotic sister chromatid cohesion|post-translational protein acetylation|regulation of DNA replication	chromatin|chromosome, centromeric region|nucleoplasm	DNA binding|protein binding			pancreas(1)	1	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATTTCTTCCTCACTTGCCTGA	0.308													22	47					0	0	0	0	T	120859281	T	T	120859281	3	4	188	1	0	0	0	0	1	0	0	0	4792	835	29	2	679	2	DSCC1	8	120859281	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	25175391	120859281	25504741	44	34760											
KIAA1797	54914	broad.mit.edu	37	chr9	20981650	20981650	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctgctctctgaagctactGggaaaatttttgacctcctg	8	14	9	10	0	2	2	0	2	2	0	4	3	3	3	2	1	3	2	2	1	4	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr9:20981650G>A	uc003zog.1	+	40	4966	c.4603G>A	c.(4603-4605)GGG>AGG	p.G1535R	KIAA1797_uc003zoh.1_Missense_Mutation_p.G971R	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1535						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		TGAAGCTACTGGGAAAATTTT	0.463													18	31					0	0	0	0	A	20981650	A	A	20981650	3	1	188	1	0	0	0	0	1	0	0	0	8297	1348	47	4	4749	4	KIAA1797	9	20981650	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08		20981650	120231781	45	34761											
CDKN2A	1029	broad.mit.edu	37	chr9	21971000	21971000	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacatcgcgatggcccagctCctcagccaggtccacgggca	8	5	12	16	3	1	0	1	0	0	0	4	2	3	0	4	3	2	2	4	3	0	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr9:21971000C>A	uc003zpk.2	-	2	570	c.358G>T	c.(358-360)GAG>TAG	p.E120*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	120	ANK 4.		E -> A (in non-small cell lung carcinoma).|E -> K (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E120*(8)|p.E120K(4)|p.E120A(1)|p.A118fs*10(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGGCCCAGCTCCTCAGCCAGG	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			15	30					3.45872e-05	3.63165e-05	1	0	A	21971000	A	A	21971000	4	1	188	1	0	0	0	0	0	1	0	0	3176	864	30	2	120	2	CDKN2A	9	21971000	Nonsense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	989350	21971000	119242431	46	34762											
CDKN2A	1029	broad.mit.edu	37	chr9	21971028	21971028	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggtccacgggcagacggccCcaggcatcgcgcacgtccag	8	3	14	16	5	0	1	0	0	0	1	3	1	2	1	4	4	0	3	4	4	0	0	rs121913389		TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr9:21971028C>T	uc003zpk.2	-	2	542	c.330G>A	c.(328-330)TGG>TGA	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.G166R	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGACGGCCCCAGGCATCGC	0.736		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	32					0	0	0	0	T	21971028	T	T	21971028	4	4	188	1	0	0	0	0	0	1	0	0	3176	624	22	4	148	4	CDKN2A	9	21971028	Nonsense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	28	21971028	119242403	47	34763											
SVEP1	79987	broad.mit.edu	37	chr9	113170491	113170491	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcctggcttgcaggtataGagagctgtgctgagataggc	10	9	15	7	0	0	2	0	1	0	2	0	4	0	2	1	3	4	5	1	3	4	4			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr9:113170491G>C	uc010mtz.2	-	38	7726	c.7389C>G	c.(7387-7389)CTC>CTG	p.L2463L	SVEP1_uc010mty.2_Silent_p.L389L	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2463	Sushi 18.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TGCAGGTATAGAGAGCTGTGC	0.478													9	24					0	0	0	0	C	113170491	C	C	113170491	2	2	188	1	0	0	0	0	0	0	0	1	15486	929	33	2		2	SVEP1	9	113170491	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08	91199463	113170491	28042940	48	34764											
KIF12	113220	broad.mit.edu	37	chr9	116859596	116859596	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacacccgtttgcaaaagttCcatcagggcctccagactcc	10	8	7	16	1	1	1	1	0	0	1	4	1	4	1	5	1	1	3	5	1	2	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr9:116859596C>T	uc004bif.2	-	4	455	c.217G>A	c.(217-219)GAA>AAA	p.E73K	KIF12_uc004big.2_RNA	NM_138424	NP_612433	Q96FN5	KIF12_HUMAN	kinesin family member 12	206	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						TGCAAAAGTTCCATCAGGGCC	0.607													3	21					0	0	0	0	T	116859596	T	T	116859596	3	4	188	1	0	0	0	0	1	0	0	0	8312	864	30	2	1376	2	KIF12	9	116859596	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	3689105	116859596	24353835	49	34765											
OR1N1	138883	broad.mit.edu	37	chr9	125288840	125288840	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccatagaacacacaaacaaCgcagaggtgggaactgcagg	16	3	11	11	1	0	2	0	0	0	2	0	3	0	3	1	3	5	2	1	3	5	1	rs151154516	byFrequency	TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr9:125288840C>T	uc004bmn.1	-	1	733	c.733G>A	c.(733-735)GTT>ATT	p.V245I		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						ACACAAACAACGCAGAGGTGG	0.547													6	31					0	0	0	0	T	125288840	T	T	125288840	3	4	188	1	0	0	0	0	1	0	0	0	11023	536	19	1	206	1	OR1N1	9	125288840	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	8429244	125288840	15924591	50	34766											
MAMDC4	158056	broad.mit.edu	37	chr9	139749038	139749038	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcctgggcccatggaacCgctcggaaggctggtcccgg	6	5	16	14	3	0	0	0	0	0	0	2	2	1	2	4	7	1	2	4	7	2	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr9:139749038C>T	uc004cjs.2	+	8	894	c.844C>T	c.(844-846)CGC>TGC	p.R282C	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	282	MAM 2.|Extracellular (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CCCATGGAACCGCTCGGAAGG	0.687													5	11					0	0	0	0	T	139749038	T	T	139749038	3	4	188	1	0	0	0	0	1	0	0	0	9257	652	23	1	874	1	MAMDC4	9	139749038	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	14460198	139749038	1464393	51	34767											
CUBN	8029	broad.mit.edu	37	chr10	17142048	17142048	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtaaagcctctcccatttCttaaatgttcagaatagaga	13	13	6	9	0	3	2	1	0	2	2	4	3	3	2	2	0	1	2	2	0	6	5			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr10:17142048C>T	uc001ioo.2	-	14	1773	c.1721G>A	c.(1720-1722)AGA>AAA	p.R574K		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	574	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCTCCCATTTCTTAAATGTTC	0.403													22	149					0	0	0	0	T	17142048	T	T	17142048	3	4	188	1	0	0	0	0	1	0	0	0	4068	913	32	2	9366	2	CUBN	10	17142048	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08		17142048	118392699	52	34768											
ITGB1	3688	broad.mit.edu	37	chr10	33208820	33208820	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacccagcttacctgcacgCgccacactcaaatgtcccat	11	7	5	18	2	1	0	1	0	0	0	2	0	2	0	4	0	3	2	4	0	2	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr10:33208820C>T	uc001iws.3	-	11	1598	c.1462G>A	c.(1462-1464)GCG>ACG	p.A488T	ITGB1_uc001iwp.3_Missense_Mutation_p.A488T|ITGB1_uc001iwq.3_Missense_Mutation_p.A488T|ITGB1_uc001iwr.3_Missense_Mutation_p.A488T|ITGB1_uc001iwt.3_Missense_Mutation_p.A488T|ITGB1_uc001iwu.1_Missense_Mutation_p.A488T	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	488	Extracellular (Potential).|I.|Cysteine-rich tandem repeats.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TACCTGCACGCGCCACACTCA	0.453													7	61					0	0	0	0	T	33208820	T	T	33208820	3	4	188	1	0	0	0	0	1	0	0	0	7929	768	27	1	1196	1	ITGB1	10	33208820	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	16066772	33208820	102325927	53	34769											
PCDH15	65217	broad.mit.edu	37	chr10	55566403	55566403	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaaagctcttcatcatcaGactgtgtgtggtcactatga	10	13	8	10	0	5	2	4	1	1	1	6	2	6	2	1	1	1	1	1	1	2	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr10:55566403G>C	uc010qhq.1	-	36	5380	c.4985C>G	c.(4984-4986)TCT>TGT	p.S1662C	PCDH15_uc010qhr.1_Missense_Mutation_p.S1657C	NM_001142771	NP_001136243	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD3-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTCATCATCAGACTGTGTGTG	0.378										HNSCC(58;0.16)			34	44					0	0	0	0	C	55566403	C	C	55566403	3	2	188	1	0	0	0	0	1	0	0	0	11565	942	33	2	67	2	PCDH15	10	55566403	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	22357583	55566403	79968344	54	34770											
GHITM	27069	broad.mit.edu	37	chr10	85903817	85903817	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttggagcattgtgctactAtggcttgggactgtctaatg	7	15	12	7	0	2	0	0	0	2	0	2	2	2	2	0	3	3	3	0	3	3	6			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr10:85903817A>G	uc001kcs.1	+	4	500	c.296A>G	c.(295-297)TAT>TGT	p.Y99C	GHITM_uc010qma.1_Missense_Mutation_p.M55V|GHITM_uc010qmb.1_Missense_Mutation_p.Y29C	NM_014394	NP_055209	Q9H3K2	GHITM_HUMAN	growth hormone inducible transmembrane protein	99	Helical; (Potential).				apoptosis	integral to membrane|mitochondrial inner membrane					0						TTGTGCTACTATGGCTTGGGA	0.418													34	71					0	0	0	0	G	85903817	G	G	85903817	3	3	188	1	0	0	0	0	1	0	0	0	6407	449	16	5	306	5	GHITM	10	85903817	Missense_Mutation	SNP	A	TCGA-CV-6003-01A-11D-1683-08	30337414	85903817	49630930	55	34771											
CCNJ	54619	broad.mit.edu	37	chr10	97810064	97810064	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctcagttaagtctcagaCggtattttgctgacttgatt	8	15	8	10	1	2	3	2	2	1	1	3	3	2	3	2	1	1	3	2	1	2	6			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr10:97810064C>T	uc001klm.2	+	3	480	c.121C>T	c.(121-123)CGG>TGG	p.R41W	uc001klg.1_Intron|uc001klj.1_Intron|uc009xvb.1_Intron|CCNJ_uc010qoq.1_Missense_Mutation_p.R41W|CCNJ_uc001kln.2_Missense_Mutation_p.R41W	NM_019084	NP_061957	Q5T5M9	CCNJ_HUMAN	cyclin J isoform 2	41	Cyclin N-terminal.					nucleus				ovary(1)	1				Epithelial(162;6.1e-08)|all cancers(201;2.32e-06)		AAGTCTCAGACGGTATTTTGC	0.478													21	47					0	0	0	0	T	97810064	T	T	97810064	3	4	188	1	0	0	0	0	1	0	0	0	2943	527	19	1	127	1	CCNJ	10	97810064	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	11906247	97810064	37724683	56	34772											
DRD4	1815	broad.mit.edu	37	chr11	640559	640559	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctacactgtcttcaacgccGagttccgcaacgtcttccgc	7	11	7	16	5	4	0	1	0	3	0	6	1	6	0	3	0	3	2	3	0	3	4			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr11:640559G>A	uc001lqp.1	+	4	1216	c.1216G>A	c.(1216-1218)GAG>AAG	p.E406K		NM_000797	NP_000788	P21917	DRD4_HUMAN	dopamine receptor D4	454	Cytoplasmic (Potential).				activation of MAPK activity|adult locomotory behavior|arachidonic acid secretion|behavioral fear response|behavioral response to cocaine|behavioral response to ethanol|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of protein secretion|positive regulation of sodium:hydrogen antiporter activity|regulation of dopamine metabolic process|regulation of inhibitory postsynaptic membrane potential|response to amphetamine|response to histamine|social behavior	integral to plasma membrane	dopamine D4 receptor activity|drug binding|potassium channel regulator activity|SH3 domain binding				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.36e-28)|Epithelial(43;2.59e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Apomorphine(DB00714)|Clozapine(DB00363)|Olanzapine(DB00334)|Pramipexole(DB00413)|Promazine(DB00420)|Propiomazine(DB00777)|Ropinirole(DB00268)|Thiethylperazine(DB00372)|Ziprasidone(DB00246)	CTTCAACGCCGAGTTCCGCAA	0.697													16	72					0	0	0	0	A	640559	A	A	640559	3	1	188	1	0	0	0	0	1	0	0	0	4781	1059	37	1	1230	1	DRD4	11	640559	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08		640559	134365957	57	34773											
MRPL17	63875	broad.mit.edu	37	chr11	6704513	6704513	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccatgggagatcgctgcagcGaccgacagccgcatgtttcc	8	7	12	14	4	0	1	0	0	0	1	2	4	1	1	4	1	3	4	4	1	0	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr11:6704513G>C	uc001men.2	-	1	120	c.15C>G	c.(13-15)GTC>GTG	p.V5V		NM_022061	NP_071344	Q9NRX2	RM17_HUMAN	mitochondrial ribosomal protein L17 precursor	5					translation	ribosome	protein domain specific binding|structural constituent of ribosome				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCGCTGCAGCGACCGACAGCC	0.632											OREG0020719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	15					0	0	0	0	C	6704513	C	C	6704513	2	2	188	1	0	0	0	0	0	0	0	1	9835	1045	37	3		3	MRPL17	11	6704513	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08	6063954	6704513	128302003	58	34774											
MICAL2	9645	broad.mit.edu	37	chr11	12265567	12265567	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaggcctgtctcatactCatcctccatctcctccctct	7	13	3	18	0	4	0	2	0	3	0	9	0	7	0	5	1	1	0	5	1	3	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr11:12265567C>A	uc001mjz.2	+	21	2980	c.2692C>A	c.(2692-2694)CAT>AAT	p.H898N	MICAL2_uc010rch.1_Intron|MICAL2_uc001mka.2_Missense_Mutation_p.H898N|MICAL2_uc010rci.1_Missense_Mutation_p.H898N|MICAL2_uc001mkb.2_Intron|MICAL2_uc001mkc.2_Intron|MICAL2_uc001mkd.2_Intron|MICAL2_uc010rcj.1_Intron|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	898						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		GTCTCATACTCATCCTCCATC	0.473													30	126					1.88708e-17	2.08572e-17	1	0	A	12265567	A	A	12265567	3	1	188	1	0	0	0	0	1	0	0	0	9623	826	29	2	2766	2	MICAL2	11	12265567	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	5561054	12265567	122740949	59	34775											
NAV2	89797	broad.mit.edu	37	chr11	20119263	20119263	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtggctatctggttggagaGaacacgaccatctcagtgac	10	10	12	9	1	2	2	1	1	2	1	3	5	2	3	1	3	1	2	1	3	2	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr11:20119263G>A	uc001mpr.3	+	31	6523	c.6162G>A	c.(6160-6162)GAG>GAA	p.E2054E	NAV2_uc001mpp.2_Silent_p.E1987E|NAV2_uc009yhx.2_Silent_p.E1115E|NAV2_uc009yhz.2_Silent_p.E696E|NAV2_uc001mpu.2_Silent_p.E489E	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	2110						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						TGGTTGGAGAGAACACGACCA	0.478													18	76					0	0	0	0	A	20119263	A	A	20119263	2	1	188	1	0	0	0	0	0	0	0	1	10237	933	33	2		2	NAV2	11	20119263	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08	7853696	20119263	114887253	60	34776											
OR5AR1	219493	broad.mit.edu	37	chr11	56432082	56432082	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcaaaaagctaattggaaaAaaatctcaataataacacaa	23	9	3	6	0	2	0	2	0	1	0	3	1	2	1	0	1	2	1	0	1	10	5			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr11:56432082A>G	uc010rjm.1	+	1	921	c.921A>G	c.(919-921)AAA>AAG	p.K307K		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TAATTGGAAAAAAATCTCAAT	0.348													11	14					0	0	0	0	G	56432082	G	G	56432082	2	3	188	1	0	0	0	0	0	0	0	1	11199	11	1	5		5	OR5AR1	11	56432082	Silent	SNP	A	TCGA-CV-6003-01A-11D-1683-08	36312819	56432082	78574434	61	34777											
KCNK4	50801	broad.mit.edu	37	chr11	64065047	64065047	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgttcgtgttctgctatatgGaggactggagcaagctggag	8	11	15	7	2	1	0	0	0	1	0	2	4	1	4	0	4	3	5	0	4	3	4			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr11:64065047G>A	uc001nzj.1	+	5	906	c.583G>A	c.(583-585)GAG>AAG	p.E195K	KCNK4_uc001nzk.1_Intron|KCNK4_uc010rnk.1_Missense_Mutation_p.E23K|KCNK4_uc001nzl.1_Intron|KCNK4_uc001nzm.3_RNA|KCNK4_uc001nzn.1_Missense_Mutation_p.E195K|KCNK4_uc001nzo.2_Missense_Mutation_p.E195K|KCNK4_uc001nzp.1_Missense_Mutation_p.E81K|C11orf20_uc009ypm.2_5'Flank	NM_033310	NP_201567	Q9NYG8	KCNK4_HUMAN	TRAAK	195						integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						CTGCTATATGGAGGACTGGAG	0.577													12	100					0	0	0	0	A	64065047	A	A	64065047	3	1	188	1	0	0	0	0	1	0	0	0	8107	1175	41	2	597	2	KCNK4	11	64065047	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	7632965	64065047	70941469	62	34778											
EHD1	10938	broad.mit.edu	37	chr11	64627529	64627529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggttgtcggggatgaggagcGggtgggaccagaaggagccg	8	5	22	6	3	0	2	0	1	0	1	1	6	0	6	2	7	2	1	2	7	1	1	rs137874978		TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr11:64627529G>A	uc001obu.1	-	3	1037	c.782C>T	c.(781-783)CCG>CTG	p.P261L	EHD1_uc001obv.1_Missense_Mutation_p.P261L|EHD1_uc010rnq.1_Missense_Mutation_p.P275L	NM_006795	NP_006786	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	261					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding				0						GATGAGGAGCGGGTGGGACCA	0.627													6	71					0	0	0	0	A	64627529	A	A	64627529	3	1	188	1	0	0	0	0	1	0	0	0	4999	1116	39	1	834	1	EHD1	11	64627529	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	562482	64627529	70378987	63	34779											
INPPL1	3636	broad.mit.edu	37	chr11	71942214	71942214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgggggcctcaaggagcttaCggatctggattaccgcccgg	7	7	15	12	4	2	0	1	0	1	0	2	3	2	3	3	6	3	1	3	6	3	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr11:71942214C>T	uc001osf.2	+	12	1625	c.1478C>T	c.(1477-1479)ACG>ATG	p.T493M	INPPL1_uc001osg.2_Missense_Mutation_p.T251M	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	493					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						AAGGAGCTTACGGATCTGGAT	0.592													154	164					0	0	0	0	T	71942214	T	T	71942214	3	4	188	1	0	0	0	0	1	0	0	0	7800	536	19	1	1524	1	INPPL1	11	71942214	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	7314685	71942214	63064302	64	34780											
GDPD5	81544	broad.mit.edu	37	chr11	75152211	75152211	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgccccccaactcaccatGatccagaggggggaaggcac	10	5	11	15	0	2	2	1	1	1	1	3	3	3	3	5	4	2	1	5	4	2	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr11:75152211G>A	uc001owo.3	-	15	2007	c.1470C>T	c.(1468-1470)ATC>ATT	p.I490I	GDPD5_uc001owp.3_Silent_p.I490I|GDPD5_uc001own.3_Silent_p.I245I|GDPD5_uc009yuc.2_Silent_p.I352I|GDPD5_uc009yud.2_Silent_p.I371I	NM_030792	NP_110419	Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain	490	Extracellular (Potential).				glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			ovary(1)	1						AACTCACCATGATCCAGAGGG	0.662													10	35					0	0	0	0	A	75152211	A	A	75152211	2	1	188	1	0	0	0	0	0	0	0	1	6364	1280	45	2		2	GDPD5	11	75152211	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08	3209997	75152211	59854305	65	34781											
KDM5A	5927	broad.mit.edu	37	chr12	406330	406330	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttcatcacaaaaaagattggGttcaagactactagaggact	16	10	8	7	0	3	3	3	0	0	3	3	4	3	4	0	2	1	1	0	2	6	5			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr12:406330G>A	uc001qif.1	-	25	4474	c.4111C>T	c.(4111-4113)CCC>TCC	p.P1371S	KDM5A_uc001qie.1_Missense_Mutation_p.P1371S	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1371					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						AAAAGATTGGGTTCAAGACTA	0.413			T 	NUP98	AML								22	30					0	0	0	0	A	406330	A	A	406330	3	1	188	1	0	0	0	0	1	0	0	0	8172	1261	44	4	977	4	KDM5A	12	406330	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08		406330	133445565	66	34782											
ZNF641	121274	broad.mit.edu	37	chr12	48737262	48737262	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaccccatacaaactgttTcccacactgggggcatgtgt	10	9	10	12	0	0	0	0	0	0	0	1	1	1	1	3	3	3	2	3	3	3	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr12:48737262T>C	uc001rrn.1	-	6	976	c.811A>G	c.(811-813)AAA>GAA	p.K271E	ZNF641_uc001rro.1_Missense_Mutation_p.K257E|ZNF641_uc010sls.1_Missense_Mutation_p.K248E	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641	271	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						ACAAACTGTTTCCCACACTGG	0.532													13	52					0	0	0	0	C	48737262	C	C	48737262	3	2	188	1	0	0	0	0	1	0	0	0	18124	1792	62	5	509	5	ZNF641	12	48737262	Missense_Mutation	SNP	T	TCGA-CV-6003-01A-11D-1683-08	48330932	48737262	85114633	67	34783											
KRT7	3855	broad.mit.edu	37	chr12	52627278	52627278	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgccggcatccgcgaggtCaccattaaccagagcctgct	8	6	12	15	4	1	1	1	0	0	1	2	2	2	1	5	3	3	2	5	3	1	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr12:52627278C>T	uc001saa.1	+	1	325	c.198C>T	c.(196-198)GTC>GTT	p.V66V	KRT7_uc009zmf.1_Silent_p.V66V	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	66	Head.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		TCCGCGAGGTCACCATTAACC	0.721													12	15					0	0	0	0	T	52627278	T	T	52627278	2	4	188	1	0	0	0	0	0	0	0	1	8522	813	29	2		2	KRT7	12	52627278	Silent	SNP	C	TCGA-CV-6003-01A-11D-1683-08	3890016	52627278	81224617	68	34784											
C12orf12	196477	broad.mit.edu	37	chr12	91348029	91348029	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggcagcgtgctcacatccGctggcgggctccgcgggtag	4	6	17	14	6	1	0	1	0	0	0	3	0	3	0	2	4	2	5	2	4	1	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr12:91348029G>A	uc001tbj.2	-	1	925	c.491C>T	c.(490-492)GCG>GTG	p.A164V		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	164										central_nervous_system(1)|pancreas(1)	2						GCTCACATCCGCTGGCGGGCT	0.687													5	31					0	0	0	0	A	91348029	A	A	91348029	3	1	188	1	0	0	0	0	1	0	0	0	1682	1087	38	1	733	1	C12orf12	12	91348029	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	38720751	91348029	42503866	69	34785											
C12orf63	374467	broad.mit.edu	37	chr12	97043730	97043733	+	Frame_Shift_Del	DEL	ACAA	-	-																															gatgaaaatatgtccaagacAcaaacagtttatgactcaga																										TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr12:97043730_97043733delACAA	uc001tet.1	+	2	105_108	c.27_30delACAA	c.(25-30)ACACAAfs	p.T9fs		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	9_10										skin(6)|ovary(1)	7						TGTCCAAGACACAAACAGTTTATG	0.299													---	---	---								-	97043733	-	-	97043730	7	5	188	1	0	1	0	1	0	0	0	0	1712	146	6	0	29	0	C12orf63	12	97043730	Frame_Shift_Del	DEL	ACAA	TCGA-CV-6003-01A-11D-1683-08	5695701	97043730	36808165	70	34786											
C12orf63	374467	broad.mit.edu	37	chr12	97085024	97085024	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagatacagggctgacatttGctctgtaattgcaagtctgt	10	14	10	7	0	2	2	0	1	2	1	2	2	2	2	0	1	3	4	0	1	4	5			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr12:97085024G>T	uc001tet.1	+	11	1553	c.1475G>T	c.(1474-1476)TGC>TTC	p.C492F		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	492										skin(6)|ovary(1)	7						GCTGACATTTGCTCTGTAATT	0.363													11	39					0.000978159	0.00101023	1	0	T	97085024	T	T	97085024	3	4	188	1	0	0	0	0	1	0	0	0	1712	1319	46	4	1513	4	C12orf63	12	97085024	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	41294	97085024	36766871	71	34787											
RPH3A	22895	broad.mit.edu	37	chr12	113332462	113332462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttgaatcccgaattcaatGaggtaaggctgccctattct	10	12	8	11	1	2	2	1	2	1	0	3	3	3	2	3	2	1	2	3	2	5	5			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr12:113332462G>A	uc010syl.1	+	20	2217	c.1855G>A	c.(1855-1857)GAG>AAG	p.E619K	RPH3A_uc001ttz.2_Missense_Mutation_p.E619K|RPH3A_uc001tty.2_Missense_Mutation_p.E615K|RPH3A_uc009zwe.1_Missense_Mutation_p.E614K|RPH3A_uc010sym.1_Missense_Mutation_p.E570K|RPH3A_uc001tua.2_Missense_Mutation_p.E379K	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	619	C2 2.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		CGAATTCAATGAGGTAAGGCT	0.448													3	11					0	0	0	0	A	113332462	A	A	113332462	3	1	188	1	0	0	0	0	1	0	0	0	13616	1291	45	2	1925	2	RPH3A	12	113332462	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	16247438	113332462	20519433	72	34788											
MCF2L	23263	broad.mit.edu	37	chr13	113728844	113728844	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgcatgtggagcacctgctGagggacctggccagcttcga	7	7	15	12	2	0	1	0	1	0	0	1	4	0	3	3	3	3	4	3	3	0	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr13:113728844G>A	uc001vsu.2	+	10	1276	c.1254G>A	c.(1252-1254)CTG>CTA	p.L418L	MCF2L_uc001vsq.2_Silent_p.L418L|MCF2L_uc010tjr.1_Silent_p.L361L|MCF2L_uc001vsr.2_Silent_p.L365L|MCF2L_uc001vss.3_Silent_p.L359L|MCF2L_uc010tjs.1_Silent_p.L359L|MCF2L_uc001vst.1_Silent_p.L323L	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	391	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				AGCACCTGCTGAGGGACCTGG	0.617													11	76					0	0	0	0	A	113728844	A	A	113728844	2	1	188	1	0	0	0	0	0	0	0	1	9432	1277	45	2		2	MCF2L	13	113728844	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08		113728844	1441034	73	34789											
JUB	84962	broad.mit.edu	37	chr14	23447637	23447651	+	In_Frame_Del	DEL	TGCACTTGATACAGG	-	-																															ctgcccatagatgcctttgtTgcacttgatacaggtgcctg																										TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr14:23447637_23447651delTGCACTTGATACAGG	uc001whz.2	-	2	1386_1400	c.1010_1024delCCTGTATCAAGTGCA	c.(1009-1026)ACCTGTATCAAGTGCAAC>AAC	p.TCIKC337del	JUB_uc001why.2_5'Flank	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	337_341	LIM zinc-binding 1.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		ATGCCTTTGTTGCACTTGATACAGGTGCCTGAGAA	0.54													---	---	---								-	23447651	-	-	23447637	7	5	188	1	0	1	0	1	0	0	0	0	8007	1812	63	0	620	0	JUB	14	23447637	In_Frame_Del	DEL	TGCACTTGATACAGG	TCGA-CV-6003-01A-11D-1683-08		23447637	83901903	74	34790											
PCNX	22990	broad.mit.edu	37	chr14	71517433	71517433	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccccatggcagatcacatGgggttctgctttccatgctt	6	13	10	12	0	2	1	1	0	1	1	3	1	3	1	3	3	3	4	3	3	0	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr14:71517433G>T	uc001xmo.2	+	23	4849	c.4403G>T	c.(4402-4404)TGG>TTG	p.W1468L	PCNX_uc010are.1_Missense_Mutation_p.W1357L|PCNX_uc010arf.1_Missense_Mutation_p.W328L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1468						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CAGATCACATGGGGTTCTGCT	0.388													84	31					6.15735e-50	6.98942e-50	1	0	T	71517433	T	T	71517433	3	4	188	1	0	0	0	0	1	0	0	0	11645	1357	47	4	4493	4	PCNX	14	71517433	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	48069796	71517433	35832107	75	34791											
DICER1	23405	broad.mit.edu	37	chr14	95570037	95570037	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcaggagagtacattcatcGctgggctggggctggttctc	6	11	14	10	1	3	1	2	0	1	1	5	2	3	1	0	5	1	5	0	5	1	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr14:95570037G>A	uc001ydw.2	-	22	3878	c.3696C>T	c.(3694-3696)AGC>AGT	p.S1232S	DICER1_uc010avh.1_Silent_p.S130S|DICER1_uc001ydv.2_Silent_p.S1222S|DICER1_uc001ydx.2_Silent_p.S1232S|DICER1_uc001ydy.1_Silent_p.S84S	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1232					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TACATTCATCGCTGGGCTGGG	0.433			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				39	77					0	0	0	0	A	95570037	A	A	95570037	2	1	188	1	0	0	0	0	0	0	0	1	4543	1078	38	1		1	DICER1	14	95570037	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08	24052604	95570037	11779503	76	34792											
IMP3	55272	broad.mit.edu	37	chr15	75932053	75932054	+	Frame_Shift_Ins	INS	-	GC	GC																															gtgacaaagtcctccatgctINSgcgcgtgacaaggaaggcgg																										TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr15:75932053_75932054insGC	uc002bat.2	-	2	1400_1401	c.456_457insGC	c.(454-459)CGCAGCfs	p.R152fs	IMP3_uc010bkl.1_Frame_Shift_Ins_p.R152fs	NM_018285	NP_060755	Q9NV31	IMP3_HUMAN	IMP3, U3 small nucleolar ribonucleoprotein	152_153	S4 RNA-binding.				rRNA processing	nucleolus|ribonucleoprotein complex	protein binding|rRNA binding				0						TCCTCCATGCTGCGCGTGACAA	0.609													---	---	---								GC	75932054	GC	GC	75932053	7	5	188	1	0	1	1	0	0	0	0	0	7758	1580	55	0	101	0	IMP3	15	75932053	Frame_Shift_Ins	INS	-	TCGA-CV-6003-01A-11D-1683-08		75932053	26599339	77	34793											
IGF1R	3480	broad.mit.edu	37	chr15	99250815	99250815	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgggccaggcatcgacatccGcaacgactatcagcagctga	11	5	11	14	4	1	1	1	1	0	0	3	3	2	1	2	2	3	4	2	2	2	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr15:99250815G>T	uc002bul.2	+	2	169	c.119G>T	c.(118-120)CGC>CTC	p.R40L	IGF1R_uc010urq.1_Missense_Mutation_p.R40L|IGF1R_uc010bon.2_Missense_Mutation_p.R40L	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	40					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	ATCGACATCCGCAACGACTAT	0.502													10	11					2.27111e-07	2.42508e-07	1	0	T	99250815	T	T	99250815	3	4	188	1	0	0	0	0	1	0	0	0	7610	1087	38	3	125	3	IGF1R	15	99250815	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	23318762	99250815	3280577	78	34794											
RNPS1	10921	broad.mit.edu	37	chr16	2314602	2314602	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactttttattattttcttTgactcctagcaagctcttct	7	20	5	9	0	3	1	0	1	3	0	4	2	4	2	1	1	2	2	1	1	4	9			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr16:2314602T>C	uc002cpt.2	-	2	589	c.43A>G	c.(43-45)AAA>GAA	p.K15E	RNPS1_uc002cpu.2_Missense_Mutation_p.K15E|RNPS1_uc002cpv.2_Intron|RNPS1_uc002cpw.2_Missense_Mutation_p.K15E|RNPS1_uc002cpx.2_Intron|RNPS1_uc010uwa.1_Intron	NM_080594	NP_542161	Q15287	RNPS1_HUMAN	RNA-binding protein S1, serine-rich domain	15	Necessary for interaction with SRP54, nuclear localization and exon-skipping.|Necessary for interaction with the cleaved p110 isoform of CDC2L1.|Lys-rich.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|termination of RNA polymerase II transcription	cytosol|nuclear speck	mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(1)	1						TTATTTTCTTTGACTCCTAGC	0.443													22	43					0	0	0	0	C	2314602	C	C	2314602	3	2	188	1	0	0	0	0	1	0	0	0	13576	1821	63	5	902	5	RNPS1	16	2314602	Missense_Mutation	SNP	T	TCGA-CV-6003-01A-11D-1683-08		2314602	88040151	79	34795											
ZNF646	9726	broad.mit.edu	37	chr16	31091299	31091299	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacaagcacgccggcagcctCatcaaccaccggcagagcca	12	3	9	17	3	2	1	2	0	0	1	2	1	2	1	5	2	5	3	5	2	3	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr16:31091299C>T	uc002eap.2	+	2	3943	c.3654C>T	c.(3652-3654)CTC>CTT	p.L1218L		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1218	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						CCGGCAGCCTCATCAACCACC	0.637													5	24					0	0	0	0	T	31091299	T	T	31091299	2	4	188	1	0	0	0	0	0	0	0	1	18129	813	29	2		2	ZNF646	16	31091299	Silent	SNP	C	TCGA-CV-6003-01A-11D-1683-08	28776697	31091299	59263454	80	34796											
SALL1	6299	broad.mit.edu	37	chr16	51174003	51174003	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctgagaacccggtggcaGatgatgcactcattggggtc	9	8	14	10	1	1	3	1	2	0	2	2	4	1	3	1	4	3	3	1	4	1	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr16:51174003G>A	uc010vgs.1	-	2	2161	c.2130C>T	c.(2128-2130)ATC>ATT	p.I710I	SALL1_uc010vgr.1_Silent_p.I613I|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	710	C2H2-type 3.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCCGGTGGCAGATGATGCACT	0.542													28	49					0	0	0	0	A	51174003	A	A	51174003	2	1	188	1	0	0	0	0	0	0	0	1	13875	932	33	2		2	SALL1	16	51174003	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08	20082704	51174003	39180750	81	34797											
GPR97	222487	broad.mit.edu	37	chr16	57719693	57719693	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accctgtcccgtgctacagcGgtcaaggagcgggggaagaa	10	5	15	11	3	1	1	1	0	0	1	2	3	2	3	2	4	4	1	2	4	4	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr16:57719693G>A	uc002emh.2	+	11	1498	c.1395G>A	c.(1393-1395)GCG>GCA	p.A465A	GPR97_uc010vhv.1_Silent_p.A345A|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_Silent_p.A73A	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	465	Cytoplasmic (Potential).			A -> V (in Ref. 4; AAH64508).	neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						GTGCTACAGCGGTCAAGGAGC	0.607													8	48					0	0	0	0	A	57719693	A	A	57719693	2	1	188	1	0	0	0	0	0	0	0	1	6759	1103	39	1		1	GPR97	16	57719693	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08	6545690	57719693	32635060	82	34798											
PLA2G15	23659	broad.mit.edu	37	chr16	68289698	68289698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccctacttcctggccctcCgcgagatgatcgaggagatg	7	8	13	13	3	0	3	0	1	0	2	3	6	2	3	4	3	1	0	4	3	1	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr16:68289698C>T	uc002evr.2	+	5	615	c.532C>T	c.(532-534)CGC>TGC	p.R178C	PLA2G15_uc010vld.1_Intron|PLA2G15_uc010vle.1_Intron|PLA2G15_uc010vlf.1_Intron|PLA2G15_uc002evs.2_5'UTR	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	lysophospholipase 3 (lysosomal phospholipase A2)	178					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			ovary(1)	1						CCTGGCCCTCCGCGAGATGAT	0.607													16	38					0	0	0	0	T	68289698	T	T	68289698	3	4	188	1	0	0	0	0	1	0	0	0	12047	652	23	1	550	1	PLA2G15	16	68289698	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	10570005	68289698	22065055	83	34799											
TMCO7	79613	broad.mit.edu	37	chr16	69056846	69056846	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccttggggagctgtgccaGaggctggactttctgctggg	6	10	16	9	0	1	1	0	0	1	1	1	3	1	3	2	5	4	3	2	5	1	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr16:69056846G>C	uc002ewi.3	+	16	2970	c.2958G>C	c.(2956-2958)CAG>CAC	p.Q986H		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	986	HEAT 2.					integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		AGCTGTGCCAGAGGCTGGACT	0.517													4	13					0	0	0	0	C	69056846	C	C	69056846	3	2	188	1	0	0	0	0	1	0	0	0	16067	933	33	2	3020	2	TMCO7	16	69056846	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	767148	69056846	21297907	84	34800											
KCNG4	93107	broad.mit.edu	37	chr16	84255948	84255948	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actggctggaccggtgttttGgaggtggcggaggcgggcct	4	9	20	8	3	0	0	0	0	0	0	0	3	0	3	2	9	0	2	2	9	0	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr16:84255948G>T	uc010voc.1	-	3	1556	c.1435C>A	c.(1435-1437)CAA>AAA	p.Q479K		NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	479	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						CCGGTGTTTTGGAGGTGGCGG	0.587													34	103					1.42033e-22	1.59787e-22	1	0	T	84255948	T	T	84255948	3	4	188	1	0	0	0	0	1	0	0	0	8069	1357	47	4	126	4	KCNG4	16	84255948	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	15199102	84255948	6098805	85	34801											
PHF23	79142	broad.mit.edu	37	chr17	7139476	7139484	+	In_Frame_Del	DEL	TCCTCTTCC	-	-																															ttgccatctcttcttcttctTcctcttcctcctcttcctcc																										TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr17:7139476_7139484delTCCTCTTCC	uc002gfa.2	-	4	989_997	c.762_770delGGAAGAGGA	c.(760-771)GAGGAAGAGGAA>GAA	p.254_257EEEE>E	DVL2_uc002gez.1_5'Flank|DVL2_uc010vtr.1_5'Flank|DVL2_uc010clz.1_5'Flank|PHF23_uc010vtt.1_In_Frame_Del_p.187_190EEEE>E|PHF23_uc010cma.2_In_Frame_Del_p.124_127EEEE>E	NM_024297	NP_077273	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	254_257	Poly-Glu.						zinc ion binding				0						ttcttcttcttcctcttcctcctcttcct	0.502													---	---	---								-	7139484	-	-	7139476	7	5	188	1	0	1	0	1	0	0	0	0	11890	1783	62	0	449	0	PHF23	17	7139476	In_Frame_Del	DEL	TCCTCTTCC	TCGA-CV-6003-01A-11D-1683-08		7139476	74055734	86	34802											
TP53	7157	broad.mit.edu	37	chr17	7574003	7574003	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaggcctcattcagctctcGgaacatctcgaagcgctcac	10	8	8	15	3	5	0	3	0	2	0	7	2	5	1	1	2	3	2	1	2	3	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr17:7574003G>A	uc002gim.2	-	10	1218	c.1024C>T	c.(1024-1026)CGA>TGA	p.R342*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.R210*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.R342*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	342	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Nuclear export signal.|Interaction with HIPK2.		R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R342*(49)|p.0?(7)|p.R342fs*3(5)|p.R342P(3)|p.R342Q(2)|p.?(1)|p.R342_N345delRELN(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCAGCTCTCGGAACATCTCG	0.498		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	8					0	0	0	0	A	7574003	A	A	7574003	4	1	188	1	0	0	0	0	0	1	0	0	16448	1124	39	1	165	1	TP53	17	7574003	Nonsense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	434527	7574003	73621207	87	34803											
AP2B1	163	broad.mit.edu	37	chr17	34001260	34001260	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acatttactcaccgccaaggGcacatctatatggaaatgaa	15	9	7	10	1	2	1	1	1	1	0	2	2	2	2	2	2	1	1	2	2	6	4			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr17:34001260G>A	uc002hjr.2	+	16	2391	c.2202G>A	c.(2200-2202)GGG>GGA	p.G734G	AP2B1_uc002hjq.2_Silent_p.G748G|AP2B1_uc010wci.1_Silent_p.G710G|AP2B1_uc002hjs.2_Silent_p.G677G|AP2B1_uc002hjt.2_Silent_p.G748G|AP2B1_uc010ctv.2_Silent_p.G748G|AP2B1_uc010wcj.1_Silent_p.G485G	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	734					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		ACCGCCAAGGGCACATCTATA	0.418													43	99					0	0	0	0	A	34001260	A	A	34001260	2	1	188	1	0	0	0	0	0	0	0	1	741	1190	42	4		4	AP2B1	17	34001260	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08	26427257	34001260	47193950	88	34804											
CASC3	22794	broad.mit.edu	37	chr17	38320341	38320341	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtacaagtggacttgagcaaGatgtggcacaactaaatata	16	9	10	6	0	0	2	0	1	0	1	0	3	0	3	0	2	3	3	0	2	8	5			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr17:38320341G>A	uc010cwt.1	+	7	1688	c.1393G>A	c.(1393-1395)GAT>AAT	p.D465N	CASC3_uc010cws.1_Missense_Mutation_p.D465N|CASC3_uc002hue.2_Missense_Mutation_p.D465N	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	465	Necessary for localization in cytoplasmic stress granules.|Nuclear export signal.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						ACTTGAGCAAGATGTGGCACA	0.517													4	30					0	0	0	0	A	38320341	A	A	38320341	3	1	188	1	0	0	0	0	1	0	0	0	2673	942	33	2	1419	2	CASC3	17	38320341	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	4319081	38320341	42874869	89	34805											
ITGA3	3675	broad.mit.edu	37	chr17	48145460	48145460	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggtgctgtggtcagggtCagaagaccagcggcgcatgg	8	6	17	10	2	2	2	2	0	0	2	2	2	2	2	2	5	2	2	2	5	1	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr17:48145460C>T	uc010dbl.2	+	4	919	c.455C>T	c.(454-456)TCA>TTA	p.S152L	ITGA3_uc010dbm.2_Missense_Mutation_p.S152L	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	152	FG-GAP 2.|Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						TGGTCAGGGTCAGAAGACCAG	0.617													25	82					0	0	0	0	T	48145460	T	T	48145460	3	4	188	1	0	0	0	0	1	0	0	0	7916	838	29	2	469	2	ITGA3	17	48145460	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	9825119	48145460	33049750	90	34806											
RNMT	8731	broad.mit.edu	37	chr18	13741657	13741657	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acttagccctgggggctattTtattggtactactcccaata	9	14	8	10	0	0	0	0	0	0	0	1	0	1	0	2	3	3	2	2	3	7	8			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr18:13741657T>C	uc002ksk.1	+	6	1008	c.941T>C	c.(940-942)TTT>TCT	p.F314S	RNMT_uc002ksl.1_Missense_Mutation_p.F314S|RNMT_uc002ksm.1_Missense_Mutation_p.F314S|RNMT_uc010dlk.2_Missense_Mutation_p.F314S|RNMT_uc010xae.1_RNA	NM_003799	NP_003790	O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	314					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding				0						GGGGGCTATTTTATTGGTACT	0.363													11	50					0	0	0	0	C	13741657	C	C	13741657	3	2	188	1	0	0	0	0	1	0	0	0	13571	1841	64	5	959	5	RNMT	18	13741657	Missense_Mutation	SNP	T	TCGA-CV-6003-01A-11D-1683-08		13741657	64335591	91	34807											
CDH7	1005	broad.mit.edu	37	chr18	63511084	63511084	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaaaacaagttacacgctaCggatagaagctgcaaataaa	19	6	7	9	2	0	1	0	0	0	1	0	2	0	2	1	1	5	4	1	1	10	4			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr18:63511084C>T	uc002ljz.2	+	7	1343	c.1018C>T	c.(1018-1020)CGG>TGG	p.R340W	CDH7_uc002lka.2_Missense_Mutation_p.R340W|CDH7_uc002lkb.2_Missense_Mutation_p.R340W	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	340	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TTACACGCTACGGATAGAAGC	0.423													14	26					0	0	0	0	T	63511084	T	T	63511084	3	4	188	1	0	0	0	0	1	0	0	0	3130	527	19	1	1040	1	CDH7	18	63511084	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	49769427	63511084	14566164	92	34808											
CDH7	1005	broad.mit.edu	37	chr18	63547695	63547695	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagagccccttatttttgaCgaagaaagagacatcagaga	17	8	9	7	1	1	5	1	1	0	4	1	8	1	5	2	0	1	0	2	0	4	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr18:63547695C>T	uc002ljz.2	+	12	2248	c.1923C>T	c.(1921-1923)GAC>GAT	p.D641D	CDH7_uc002lkb.2_Silent_p.D641D	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	641	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TTATTTTTGACGAAGAAAGAG	0.443													8	24					0	0	0	0	T	63547695	T	T	63547695	2	4	188	1	0	0	0	0	0	0	0	1	3130	535	19	1		1	CDH7	18	63547695	Silent	SNP	C	TCGA-CV-6003-01A-11D-1683-08	36611	63547695	14529553	93	34809											
CPAMD8	27151	broad.mit.edu	37	chr19	17004117	17004117	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgctgctttccaggttcccGctgctcacaggaggccgagg	5	9	14	13	2	1	0	1	0	0	0	3	2	3	1	3	4	3	5	3	4	0	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr19:17004117G>A	uc002nfb.2	-	42	5633	c.5601C>T	c.(5599-5601)AGC>AGT	p.S1867S	CPAMD8_uc010xpj.1_3'UTR|CPAMD8_uc002nfd.1_3'UTR	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1820						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CCAGGTTCCCGCTGCTCACAG	0.642													3	2					0	0	0	0	A	17004117	A	A	17004117	2	1	188	1	0	0	0	0	0	0	0	1	3810	1078	38	1		1	CPAMD8	19	17004117	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08		17004117	42124866	94	34810											
CLPTM1	1209	broad.mit.edu	37	chr19	45496031	45496031	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccacacctgcacccaccaCgaccaccgccaccagggagg	10	1	9	21	2	0	0	0	0	0	0	0	2	0	1	8	2	1	1	8	2	0	0	rs148362509	byFrequency	TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr19:45496031C>T	uc002pai.2	+	14	1901	c.1886C>T	c.(1885-1887)ACG>ATG	p.T629M	CLPTM1_uc010xxf.1_Missense_Mutation_p.T527M|CLPTM1_uc010xxg.1_Missense_Mutation_p.T615M	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	629	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GCACCCACCACGACCACCGCC	0.697													5	35					0	0	0	0	T	45496031	T	T	45496031	3	4	188	1	0	0	0	0	1	0	0	0	3569	536	19	1	1940	1	CLPTM1	19	45496031	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	28491914	45496031	13632952	95	34811											
ZNF347	84671	broad.mit.edu	37	chr19	53644779	53644779	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgaacaccaaaggctttgccGcactcattacacttgtaagg	12	9	8	12	2	1	0	1	0	0	0	1	1	1	0	2	2	3	3	2	2	4	4	rs77716783	byFrequency	TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr19:53644779G>A	uc002qbb.1	-	5	1371	c.1302C>T	c.(1300-1302)TGC>TGT	p.C434C	ZNF347_uc010eql.1_Silent_p.C435C|ZNF347_uc002qbc.1_Silent_p.C435C	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	434	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		AGGCTTTGCCGCACTCATTAC	0.423													38	51					0	0	0	0	A	53644779	A	A	53644779	2	1	188	1	0	0	0	0	0	0	0	1	17928	1079	38	1		1	ZNF347	19	53644779	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08	8148748	53644779	5484204	96	34812											
PYGB	5834	broad.mit.edu	37	chr20	25262744	25262744	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcaccccccgccggtggctGctgctgtgcaacccggggct	4	7	13	17	3	1	0	1	0	0	0	1	0	1	0	5	4	4	5	5	4	1	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr20:25262744G>T	uc002wup.2	+	12	1588	c.1479G>T	c.(1477-1479)CTG>CTT	p.L493L		NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	493					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	GCCGGTGGCTGCTGCTGTGCA	0.592													11	22					9.7654e-05	0.000101689	1	0	T	25262744	T	T	25262744	2	4	188	1	0	0	0	0	0	0	0	1	12925	1306	46	4		4	PYGB	20	25262744	Silent	SNP	G	TCGA-CV-6003-01A-11D-1683-08		25262744	37762776	97	34813											
ZNFX1	57169	broad.mit.edu	37	chr20	47864939	47864939	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccacaaactagcagcttaGtacaaggcacatagcatggg	14	6	11	10	0	0	0	0	0	0	0	0	0	0	0	1	3	5	5	1	3	6	4			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr20:47864939G>C	uc002xui.2	-	14	4869	c.4622C>G	c.(4621-4623)ACT>AGT	p.T1541S		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1541							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TAGCAGCTTAGTACAAGGCAC	0.572													43	60					0	0	0	0	C	47864939	C	C	47864939	3	2	188	1	0	0	0	0	1	0	0	0	18272	1029	36	4	1138	4	ZNFX1	20	47864939	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	22602195	47864939	15160581	98	34814											
TH1L	51497	broad.mit.edu	37	chr20	57568743	57568743	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcgaggttatgtacttcCtgttgtcagttacatccgaa	9	14	10	8	2	1	0	1	0	0	0	4	3	3	0	2	1	2	4	2	1	4	5			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr20:57568743C>T	uc002yag.2	+	13	1559	c.1532C>T	c.(1531-1533)CCT>CTT	p.P511L	TH1L_uc002yaf.1_RNA|TH1L_uc002yah.2_Intron	NM_198976	NP_945327	Q8IXH7	NELFD_HUMAN	TH1-like protein	511					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)			TATGTACTTCCTGTTGTCAGT	0.483													12	51					0	0	0	0	T	57568743	T	T	57568743	3	4	188	1	0	0	0	0	1	0	0	0	15905	681	24	4	1582	4	TH1L	20	57568743	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	9703804	57568743	5456777	99	34815											
GRAMD4	23151	broad.mit.edu	37	chr22	47059754	47059754	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttaactgaaaatatgagaCggctcagtgagtaccagcgg	13	8	13	7	2	1	3	1	3	0	1	1	4	1	3	1	3	3	3	1	3	5	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chr22:47059754C>T	uc003bhx.2	+	6	658	c.619C>T	c.(619-621)CGG>TGG	p.R207W	GRAMD4_uc010had.2_Missense_Mutation_p.R146W	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	207					apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		AAATATGAGACGGCTCAGTGA	0.617													9	34					0	0	0	0	T	47059754	T	T	47059754	3	4	188	1	0	0	0	0	1	0	0	0	6791	527	19	1	641	1	GRAMD4	22	47059754	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08		47059754	4244812	100	34816											
NLGN4X	57502	broad.mit.edu	37	chrX	5821173	5821173	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacggcgctgagcatgacgtCgttcttggaaaagttacaac	11	9	11	10	4	1	2	0	2	1	0	2	3	1	3	0	2	3	4	0	2	4	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:5821173C>T	uc010ndh.2	-	5	2047	c.1546G>A	c.(1546-1548)GAC>AAC	p.D516N	NLGN4X_uc004crp.2_Missense_Mutation_p.D536N|NLGN4X_uc004crq.2_Missense_Mutation_p.D516N|NLGN4X_uc010ndi.2_Missense_Mutation_p.D553N|NLGN4X_uc004crr.2_Missense_Mutation_p.D516N|NLGN4X_uc010ndj.2_Missense_Mutation_p.D516N	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	516	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						AGCATGACGTCGTTCTTGGAA	0.537													27	88					0	0	0	0	T	5821173	T	T	5821173	3	4	188	1	0	0	0	0	1	0	0	0	10518	884	31	1	912	1	NLGN4X	23	5821173	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08		5821173	149449387	101	34817											
CASK	8573	broad.mit.edu	37	chrX	41401990	41401990	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttgtactgcttctttttCttgccaaaccaagtacagct	8	17	5	11	0	3	0	0	0	3	0	3	0	3	0	2	0	6	4	2	0	4	7			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:41401990C>G	uc004dfl.3	-	22	2155	c.2109G>C	c.(2107-2109)AAG>AAC	p.K703N	CASK_uc004dfj.3_Missense_Mutation_p.K243N|CASK_uc004dfk.3_Missense_Mutation_p.K518N|CASK_uc004dfm.3_Missense_Mutation_p.K680N|CASK_uc004dfn.3_Missense_Mutation_p.K674N	NM_003688	NP_003679	O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein	703					cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			ovary(3)|lung(2)|stomach(1)	6						GCTTCTTTTTCTTGCCAAACC	0.418													9	69					0	0	0	0	G	41401990	G	G	41401990	3	3	188	1	0	0	0	0	1	0	0	0	2677	912	32	2	695	2	CASK	23	41401990	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	35580817	41401990	113868570	102	34818											
USP11	8237	broad.mit.edu	37	chrX	47101692	47101692	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatccccatggatccgcgccGcaagccagagcaggtgtggg	8	6	14	13	3	0	1	0	0	0	1	2	2	2	2	5	3	2	2	5	3	2	1			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:47101692G>A	uc004dhp.2	+	10	1520	c.1520G>A	c.(1519-1521)CGC>CAC	p.R507H	USP11_uc004dhq.2_Missense_Mutation_p.R234H	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	507					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GATCCGCGCCGCAAGCCAGAG	0.542													6	22					0	0	0	0	A	47101692	A	A	47101692	3	1	188	1	0	0	0	0	1	0	0	0	17110	1087	38	1	1558	1	USP11	23	47101692	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	5699702	47101692	108168868	103	34819											
ZNF81	347344	broad.mit.edu	37	chrX	47774432	47774432	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gattcattatactctattttAgaagaattgtggcaagatgc	13	15	8	5	0	2	3	1	0	1	3	2	4	2	3	0	1	2	1	0	1	7	7			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:47774432A>T	uc010nhy.1	+	6	755	c.387A>T	c.(385-387)TTA>TTT	p.L129F		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	129						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				ACTCTATTTTAGAAGAATTGT	0.353													21	25					0	0	0	0	T	47774432	T	T	47774432	3	4	188	1	0	0	0	0	1	0	0	0	18241	417	15	5	401	5	ZNF81	23	47774432	Missense_Mutation	SNP	A	TCGA-CV-6003-01A-11D-1683-08	672740	47774432	107496128	104	34820											
FGD1	2245	broad.mit.edu	37	chrX	54476096	54476096	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcggggactcttactggaGagttgggtggggtgtcttca	5	11	19	6	1	3	1	1	0	2	1	3	3	3	2	0	7	1	1	0	7	1	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:54476096G>A	uc004dtg.2	-	14	2878	c.2144C>T	c.(2143-2145)TCT>TTT	p.S715F	FGD1_uc011moi.1_Missense_Mutation_p.S473F	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	715					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TCTTACTGGAGAGTTGGGTGG	0.532													11	126					0	0	0	0	A	54476096	A	A	54476096	3	1	188	1	0	0	0	0	1	0	0	0	5864	942	33	2	761	2	FGD1	23	54476096	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	6701664	54476096	100794464	105	34821											
ZCCHC13	389874	broad.mit.edu	37	chrX	73524500	73524500	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caggtcaagtgttaccgatgCggcgagattggccacgtggc	8	8	15	10	4	1	1	1	0	0	1	1	3	1	1	2	4	2	1	2	4	2	2			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:73524500C>A	uc004ebs.3	+	1	476	c.399C>A	c.(397-399)TGC>TGA	p.C133*		NM_203303	NP_976048	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	133	CCHC-type 6.						nucleic acid binding|zinc ion binding				0						GTTACCGATGCGGCGAGATTG	0.552													13	28					0.00136819	0.00139026	1	0	A	73524500	A	A	73524500	4	1	188	1	0	0	0	0	0	1	0	0	17649	776	27	3	401	3	ZCCHC13	23	73524500	Nonsense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	19048404	73524500	81746060	106	34822											
ATP7A	538	broad.mit.edu	37	chrX	77267139	77267139	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggattgtctgttatgaatTtgctgtcctttttattgtgt	6	21	9	5	0	1	1	0	1	1	0	2	2	2	2	1	1	1	2	1	1	3	7			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:77267139T>G	uc004ecx.3	+	9	2300	c.2140T>G	c.(2140-2142)TTG>GTG	p.L714V	ATP7A_uc004ecw.2_3'UTR	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	714	Extracellular (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TGTTATGAATTTGCTGTCCTT	0.333													97	184					0	0	0	0	G	77267139	G	G	77267139	3	3	188	1	0	0	0	0	1	0	0	0	1192	1838	64	5	2170	5	ATP7A	23	77267139	Missense_Mutation	SNP	T	TCGA-CV-6003-01A-11D-1683-08	3742639	77267139	78003421	107	34823											
TBX22	50945	broad.mit.edu	37	chrX	79281158	79281158	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatacagaccatttgtgcaTcattcctagattctatgttc	11	15	6	9	0	2	2	1	0	1	2	4	3	3	2	2	0	2	2	2	0	4	7			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:79281158T>A	uc010nmg.1	+	5	649	c.515T>A	c.(514-516)ATC>AAC	p.I172N	TBX22_uc004edi.1_Missense_Mutation_p.I52N|TBX22_uc004edj.1_Missense_Mutation_p.I172N	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	172	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CATTTGTGCATCATTCCTAGA	0.498													17	62					0	0	0	0	A	79281158	A	A	79281158	3	1	188	1	0	0	0	0	1	0	0	0	15724	1435	50	5	529	5	TBX22	23	79281158	Missense_Mutation	SNP	T	TCGA-CV-6003-01A-11D-1683-08	2014019	79281158	75989402	108	34824											
PCDH11X	27328	broad.mit.edu	37	chrX	91131788	91131788	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgttttccagagtcaaaaCatttttggcctcgatgtcat	10	15	7	9	1	2	1	2	0	0	1	4	2	3	1	2	1	1	1	2	1	2	4			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:91131788C>A	uc004efk.1	+	2	1394	c.549C>A	c.(547-549)AAC>AAA	p.N183K	PCDH11X_uc004efl.1_Missense_Mutation_p.N183K|PCDH11X_uc004efo.1_Missense_Mutation_p.N183K|PCDH11X_uc010nmv.1_Missense_Mutation_p.N183K|PCDH11X_uc004efm.1_Missense_Mutation_p.N183K|PCDH11X_uc004efn.1_Missense_Mutation_p.N183K|PCDH11X_uc004efh.1_Missense_Mutation_p.N183K|PCDH11X_uc004efj.1_Missense_Mutation_p.N183K	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	183	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						AGAGTCAAAACATTTTTGGCC	0.284													20	48					2.39556e-15	2.62471e-15	1	0	A	91131788	A	A	91131788	3	1	188	1	0	0	0	0	1	0	0	0	11562	477	17	4	555	4	PCDH11X	23	91131788	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	11850630	91131788	64138772	109	34825											
TCEAL6	158931	broad.mit.edu	37	chrX	101396190	101396190	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcattctgtcttcccctcCgcgtctggcttttcttcctc	1	17	6	17	3	4	0	0	0	4	0	9	0	7	0	4	1	0	2	4	1	0	5			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:101396190C>T	uc004eiq.2	-	3	275	c.114G>A	c.(112-114)GCG>GCA	p.A38A		NM_001006938	NP_001006939	Q6IPX3	TCAL6_HUMAN	transcription elongation factor A (SII)-like 6	38	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.A38T(1)		ovary(1)	1						tcttcccctccgcgtctggct	0.144													11	53					0	0	0	0	T	101396190	T	T	101396190	2	4	188	1	0	0	0	0	0	0	0	1	15741	639	23	1		1	TCEAL6	23	101396190	Silent	SNP	C	TCGA-CV-6003-01A-11D-1683-08	10264402	101396190	53874370	110	34826											
RGAG1	57529	broad.mit.edu	37	chrX	109694331	109694332	+	Frame_Shift_Del	DEL	AG	-	-																															atggtagcaccagattctgcAgagatatcaccattggcaat																										TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:109694331_109694332delAG	uc004eor.1	+	3	732_733	c.486_487delAG	c.(484-489)GCAGAGfs	p.A162fs	RGAG1_uc011msr.1_Frame_Shift_Del_p.A162fs	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	162_163										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CAGATTCTGCAGAGATATCACC	0.48													---	---	---								-	109694332	-	-	109694331	7	5	188	1	0	1	0	1	0	0	0	0	13339	175	7	0	488	0	RGAG1	23	109694331	Frame_Shift_Del	DEL	AG	TCGA-CV-6003-01A-11D-1683-08	8298141	109694331	45576229	111	34827											
OCRL	4952	broad.mit.edu	37	chrX	128696645	128696645	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgcattgtcaattcccatCtggctgcacacgtggaggac	8	12	10	11	1	2	0	1	0	1	0	3	2	3	2	1	3	2	3	1	3	1	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:128696645C>G	uc004euq.2	+	12	1291	c.1126C>G	c.(1126-1128)CTG>GTG	p.L376V	OCRL_uc004eur.2_Missense_Mutation_p.L376V	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	376					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						CAATTCCCATCTGGCTGCACA	0.428													21	96					0	0	0	0	G	128696645	G	G	128696645	3	3	188	1	0	0	0	0	1	0	0	0	10877	912	32	2	1172	2	OCRL	23	128696645	Missense_Mutation	SNP	C	TCGA-CV-6003-01A-11D-1683-08	19002314	128696645	26573915	112	34828											
BCORL1	63035	broad.mit.edu	37	chrX	129159271	129159271	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgctgaagaggaagaaacGaagacggcagaagagccgaa	17	2	14	8	3	0	6	0	1	0	5	0	9	0	7	2	2	3	2	2	2	6	0			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:129159271G>A	uc004evb.1	+	7	4109	c.3995G>A	c.(3994-3996)CGA>CAA	p.R1332Q	BCORL1_uc010nrd.1_Intron|BCORL1_uc004evc.1_Missense_Mutation_p.R94Q	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1332	Nuclear localization signal (Potential).				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						AGGAAGAAACGAAGACGGCAG	0.498													42	39					0	0	0	0	A	129159271	A	A	129159271	3	1	188	1	0	0	0	0	1	0	0	0	1389	1058	37	1	4017	1	BCORL1	23	129159271	Missense_Mutation	SNP	G	TCGA-CV-6003-01A-11D-1683-08	462626	129159271	26111289	113	34829											
SPANXN1	494118	broad.mit.edu	37	chrX	144337190	144337190	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctccctgttttcttaacaGatgcaggagacaccaaacag	12	10	7	12	0	2	2	0	0	2	2	3	3	2	2	2	1	3	2	2	1	2	3			TCGA-CV-6003-01A-11D-1683-08	TCGA-CV-6003-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	9a040a5e-3d2b-433a-9786-7c26b433c0c2	b2300f2e-710b-48ba-9a65-ae9742efe92d	g.chrX:144337190G>A	uc004fcb.2	+	2	76	c.76_splice	c.e2-1	p.M26_splice		NM_001009614	NP_001009614	Q5VSR9	SPXN1_HUMAN	SPANX-N1 protein												0	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCTTAACAGATGCAGGAGA	0.443													16	69					0	0	0	0	A	144337190	A	A	144337190	5	1	188	1	0	0	0	0	0	0	1	0	15056	956	33	2	81	2	SPANXN1	23	144337190	Splice_Site	SNP	G	TCGA-CV-6003-01A-11D-1683-08	15177919	144337190	10933370	114	34830											
AHDC1	27245	broad.mit.edu	37	chr1	27874105	27874105	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggccttgggcgtggctggtgGgctagccaggtgaggggcac	4	7	21	9	1	0	1	0	1	0	0	0	1	0	1	2	8	1	3	2	8	1	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:27874105G>C	uc009vsy.2	-	6	5491	c.4522C>G	c.(4522-4524)CCA>GCA	p.P1508A	AHDC1_uc009vsz.1_Missense_Mutation_p.P1508A	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1508							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GTGGCTGGTGGGCTAGCCAGG	0.711													3	8					0	0	0	0	C	27874105	C	C	27874105	3	2	189	1	0	0	0	0	1	0	0	0	412	1232	43	4	293	4	AHDC1	1	27874105	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08		27874105	221376516	1	34831											
C1orf103	55791	broad.mit.edu	37	chr1	111490996	111490996	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatcttcttattagtttttGcttttcttttcttatcaaaa	8	23	2	8	0	5	0	1	0	4	0	5	0	5	0	1	0	1	2	1	0	5	10			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:111490996G>A	uc001eaa.2	-	4	2151	c.1895C>T	c.(1894-1896)GCA>GTA	p.A632V	C1orf103_uc001dzz.2_Missense_Mutation_p.A96V|C1orf103_uc001eab.2_Missense_Mutation_p.A96V|C1orf103_uc001eac.1_Missense_Mutation_p.A95V	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		ATTAGTTTTTGCTTTTCTTTT	0.343													11	22					0	0	0	0	A	111490996	A	A	111490996	3	1	189	1	0	0	0	0	1	0	0	0	1986	1319	46	4	418	4	C1orf103	1	111490996	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	83616891	111490996	137759625	2	34832											
NBPF7	343505	broad.mit.edu	37	chr1	120382017	120382017	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttcttcagccttctgctcctCcctgatgagccaggtgggat	5	13	10	13	0	3	2	1	2	2	0	5	3	5	3	4	2	3	1	4	2	0	3			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:120382017C>G	uc010oxk.1	-	5	1249	c.628G>C	c.(628-630)GAG>CAG	p.E210Q		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	210	NBPF 1.					cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		TTCTGCTCCTCCCTGATGAGC	0.502													23	158					0	0	0	0	G	120382017	G	G	120382017	3	3	189	1	0	0	0	0	1	0	0	0	10252	869	30	2	652	2	NBPF7	1	120382017	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	8891021	120382017	128868604	3	34833											
APOA1BP	128240	broad.mit.edu	37	chr1	156563322	156563322	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagggactcactgtgccCattgccagcatcgacattcc	9	9	9	14	1	1	1	1	1	0	0	3	3	2	2	3	1	3	1	3	1	1	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:156563322C>T	uc001fph.2	+	5	678	c.639C>T	c.(637-639)CCC>CCT	p.P213P	APOA1BP_uc001fpg.2_Silent_p.P213P|APOA1BP_uc001fpi.2_Missense_Mutation_p.H195Y|APOA1BP_uc001fpj.2_Silent_p.P130P|APOA1BP_uc001fpk.2_Silent_p.P110P|APOA1BP_uc010php.1_Silent_p.P110P	NM_144772	NP_658985	Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein precursor	213	YjeF N-terminal.					extracellular region	protein binding			central_nervous_system(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCACTGTGCCCATTGCCAGCA	0.577													5	46					0	0	0	0	T	156563322	T	T	156563322	2	4	189	1	0	0	0	0	0	0	0	1	781	581	21	4		4	APOA1BP	1	156563322	Silent	SNP	C	TCGA-CV-6433-01A-11D-1683-08	36181305	156563322	92687299	4	34834											
METTL13	51603	broad.mit.edu	37	chr1	171756952	171756952	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagccccttgagcggtgaCtatgtcattgaggatgtgca	8	11	13	9	1	1	3	1	3	0	0	1	4	1	4	2	2	4	2	2	2	1	3			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:171756952C>A	uc001ghz.2	+	4	1538	c.1191C>A	c.(1189-1191)GAC>GAA	p.D397E	METTL13_uc001gia.2_Missense_Mutation_p.D311E|METTL13_uc001gib.2_Missense_Mutation_p.D241E|METTL13_uc010pml.1_Missense_Mutation_p.D396E	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	397							methyltransferase activity|protein binding			kidney(1)	1						TGAGCGGTGACTATGTCATTG	0.552													3	33					0.004672	0.0050808	1	0	A	171756952	A	A	171756952	3	1	189	1	0	0	0	0	1	0	0	0	9550	564	20	4	1205	4	METTL13	1	171756952	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	15193630	171756952	77493669	5	34835											
C1orf125	126859	broad.mit.edu	37	chr1	179460728	179460728	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtaaacttgctgattttaaTgatacccaactttactgacc	12	14	6	9	0	0	3	0	3	0	0	0	3	0	3	2	1	5	2	2	1	6	7			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:179460728T>G	uc001gmo.2	+	19	2274	c.2147T>G	c.(2146-2148)ATG>AGG	p.M716R	C1orf125_uc009wxg.2_RNA|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.M716R|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	716											0						CTGATTTTAATGATACCCAAC	0.363													29	57					0	0	0	0	G	179460728	G	G	179460728	3	3	189	1	0	0	0	0	1	0	0	0	2002	1464	51	5	2217	5	C1orf125	1	179460728	Missense_Mutation	SNP	T	TCGA-CV-6433-01A-11D-1683-08	7703776	179460728	69789893	6	34836											
IGFN1	91156	broad.mit.edu	37	chr1	201185880	201185880	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagatattggtggctcctgaGggtgagagaaaaggctgggg	10	8	19	4	0	0	4	0	2	0	2	1	6	1	4	1	6	0	2	1	6	3	2	rs35601315		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:201185880G>A	uc001gwc.2	+	5	1846	c.1074G>A	c.(1072-1074)GAG>GAA	p.E358E	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						TGGCTCCTGAGGGTGAGAGAA	0.647													28	37					0	0	0	0	A	201185880	A	A	201185880	2	1	189	1	0	0	0	0	0	0	0	1	7629	1014	35	4		4	IGFN1	1	201185880	Silent	SNP	G	TCGA-CV-6433-01A-11D-1683-08	21725152	201185880	48064741	7	34837											
ACTN2	88	broad.mit.edu	37	chr1	236924422	236924422	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actagagagacggctgacacCgacactgccgagcaggtcat	12	5	12	12	3	1	3	1	1	0	2	1	6	1	3	2	2	2	2	2	2	1	1			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:236924422C>T	uc001hyf.2	+	20	2679	c.2475C>T	c.(2473-2475)ACC>ACT	p.T825T	ACTN2_uc001hyg.2_Silent_p.T617T|ACTN2_uc009xgi.1_Silent_p.T825T|ACTN2_uc010pxu.1_Silent_p.T514T|ACTN2_uc001hyh.2_Silent_p.T513T	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	825					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGGCTGACACCGACACTGCCG	0.537													27	34					0	0	0	0	T	236924422	T	T	236924422	2	4	189	1	0	0	0	0	0	0	0	1	205	639	23	1		1	ACTN2	1	236924422	Silent	SNP	C	TCGA-CV-6433-01A-11D-1683-08	35738542	236924422	12326199	8	34838											
ASAP2	8853	broad.mit.edu	37	chr2	9515038	9515038	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagcttatgctgatggtgtgGatcttacggaaaaaatccca	13	11	10	7	1	1	1	0	1	1	0	2	3	2	3	1	3	3	2	1	3	6	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr2:9515038G>A	uc002qzh.2	+	17	2051	c.1711G>A	c.(1711-1713)GAT>AAT	p.D571N	ASAP2_uc002qzi.2_Missense_Mutation_p.D571N	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	571					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						TGATGGTGTGGATCTTACGGA	0.388													23	39					0	0	0	0	A	9515038	A	A	9515038	3	1	189	1	0	0	0	0	1	0	0	0	1013	1174	41	2	1777	2	ASAP2	2	9515038	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08		9515038	233684335	9	34839											
TMEFF2	23671	broad.mit.edu	37	chr2	192922459	192922459	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caaactggcaaatatcacagGtggatgtctccttttgacta	12	12	8	9	0	2	1	1	1	1	0	3	2	2	2	1	3	1	1	1	3	4	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr2:192922459G>A	uc002utc.2	-	5	876	c.482C>T	c.(481-483)ACC>ATC	p.T161I		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	161	Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			AATATCACAGGTGGATGTCTC	0.378													26	50					0	0	0	0	A	192922459	A	A	192922459	3	1	189	1	0	0	0	0	1	0	0	0	16080	1261	44	4	666	4	TMEFF2	2	192922459	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	183407421	192922459	50276914	10	34840											
SACM1L	22908	broad.mit.edu	37	chr3	45776796	45776796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgttccgaagcaattgcatGgattgtctagatagaaccaa	13	11	10	7	1	1	2	0	0	1	2	2	4	2	3	2	1	3	3	2	1	6	5			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:45776796G>A	uc003cos.2	+	14	1374	c.1170G>A	c.(1168-1170)ATG>ATA	p.M390I	SACM1L_uc011bag.1_Missense_Mutation_p.M287I|SACM1L_uc011bah.1_Missense_Mutation_p.M324I|SACM1L_uc003cot.2_Missense_Mutation_p.M33I	NM_014016	NP_054735	Q9NTJ5	SAC1_HUMAN	suppressor of actin 1	390	SAC.					Golgi apparatus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		GCAATTGCATGGATTGTCTAG	0.408													19	53					0	0	0	0	A	45776796	A	A	45776796	3	1	189	1	0	0	0	0	1	0	0	0	13868	1348	47	4	1224	4	SACM1L	3	45776796	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08		45776796	152245634	11	34841											
CELSR3	1951	broad.mit.edu	37	chr3	48699612	48699613	+	Missense_Mutation	DNP	AC	TT	TT																															gacagagcccctggtgacagActacctctttgcaaaggtcc																										TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:48699612_48699613AC>TT	uc003cul.2	-	1	736_737	c.455_456GT>AA	c.(454-456)AGT>AAA	p.S152K	CELSR3_uc003cuf.1_Missense_Mutation_p.S222K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	152	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTGGTGACAGACTACCTCTTTG	0.629													45	85					0	0	0	0	TT	48699613	TT	TT	48699612	3	4	189	1	0	0	0	0	1	0	0	0	3238	272	10	5	9622	5	CELSR3	3	48699612	Missense_Mutation	DNP	AC	TCGA-CV-6433-01A-11D-1683-08	2922816	48699612	149322818	12	34842											
LRRIQ4	344657	broad.mit.edu	37	chr3	169540270	169540270	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccaggagctctgtgttctCtacaccctggaaatcattga	9	11	8	13	0	3	1	1	1	2	0	4	3	3	3	3	2	2	2	3	2	2	3			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:169540270C>G	uc003fgb.2	+	1	561	c.561C>G	c.(559-561)CTC>CTG	p.L187L		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	187	LRR 7.										0						TCTGTGTTCTCTACACCCTGG	0.488													4	124					0	0	0	0	G	169540270	G	G	169540270	2	3	189	1	0	0	0	0	0	0	0	1	9081	900	32	2		2	LRRIQ4	3	169540270	Silent	SNP	C	TCGA-CV-6433-01A-11D-1683-08	120840658	169540270	28482160	13	34843											
STIM2	57620	broad.mit.edu	37	chr4	27003875	27003875	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgaaagattttatcctcaCagtttctatagtaattggtg	12	16	8	5	0	2	2	1	1	1	1	3	3	3	2	1	1	0	2	1	1	5	7			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:27003875C>T	uc003gsh.3	+	6	1139	c.923C>T	c.(922-924)ACA>ATA	p.T308I	STIM2_uc003gsg.3_Missense_Mutation_p.T308I|STIM2_uc010iex.2_Missense_Mutation_p.T308I|STIM2_uc010iey.2_5'Flank	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	221	Helical; (Potential).				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				TTTATCCTCACAGTTTCTATA	0.343													3	37					0	0	0	0	T	27003875	T	T	27003875	3	4	189	1	0	0	0	0	1	0	0	0	15350	478	17	4	684	4	STIM2	4	27003875	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08		27003875	164150401	14	34844											
TEC	7006	broad.mit.edu	37	chr4	48169913	48169913	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttggaaatcatacatggctaCaacgatttcttcactattat	13	15	5	8	1	3	0	2	0	1	0	3	2	3	1	0	2	3	1	0	2	6	7			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:48169913C>T	uc003gxz.2	-	7	644	c.553G>A	c.(553-555)GTA>ATA	p.V185I		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	185	SH3.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						TACATGGCTACAACGATTTCT	0.393													6	97					0	0	0	0	T	48169913	T	T	48169913	3	4	189	1	0	0	0	0	1	0	0	0	15808	478	17	4	1390	4	TEC	4	48169913	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	21166038	48169913	142984363	15	34845											
GNRHR	2798	broad.mit.edu	37	chr4	68610290	68610290	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctaaggaatacataccgtgGgggtcctgatgaaggacccg	11	8	13	9	2	1	2	0	2	1	0	2	4	2	4	3	4	2	0	3	4	5	3			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:68610290G>A	uc003hdn.2	-	2	2489	c.738C>T	c.(736-738)CCC>CCT	p.P246P	LOC550112_uc003hdl.3_Intron|GNRHR_uc003hdm.2_Missense_Mutation_p.P204S	NM_000406	NP_000397	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor isoform	246	Cytoplasmic (Potential).				multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			ovary(1)	1					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	ACATACCGTGGGGGTCCTGAT	0.388													20	26					0	0	0	0	A	68610290	A	A	68610290	2	1	189	1	0	0	0	0	0	0	0	1	6586	1232	43	4		4	GNRHR	4	68610290	Silent	SNP	G	TCGA-CV-6433-01A-11D-1683-08	20440377	68610290	122543986	16	34846											
ANKRD17	26057	broad.mit.edu	37	chr4	73963791	73963791	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aataaaaattggaactaactTtattgaagccttgccagaaa	18	11	6	6	0	0	2	0	1	0	1	0	3	0	3	2	1	4	0	2	1	9	7			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:73963791T>G	uc003hgp.2	-	26	5137	c.5020A>C	c.(5020-5022)AAA>CAA	p.K1674Q	ANKRD17_uc003hgo.2_Missense_Mutation_p.K1561Q|ANKRD17_uc003hgq.2_Missense_Mutation_p.K1423Q|ANKRD17_uc003hgr.2_Missense_Mutation_p.K1673Q	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1674	Ser-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGAACTAACTTTATTGAAGCC	0.333													28	50					0	0	0	0	G	73963791	G	G	73963791	3	3	189	1	0	0	0	0	1	0	0	0	646	1855	64	5	2827	5	ANKRD17	4	73963791	Missense_Mutation	SNP	T	TCGA-CV-6433-01A-11D-1683-08	5353501	73963791	117190485	17	34847											
SMARCA5	8467	broad.mit.edu	37	chr4	144467996	144467996	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatgagaagtggggtcgtgAtgatattgaaaatatagcaa	16	11	12	2	1	0	4	0	4	0	1	1	5	0	4	0	2	1	1	0	2	8	5			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:144467996A>G	uc003ijg.2	+	20	3050	c.2588A>G	c.(2587-2589)GAT>GGT	p.D863G		NM_003601	NP_003592	O60264	SMCA5_HUMAN	SWI/SNF-related matrix-associated	863	SANT 1.				CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)					TGGGGTCGTGATGATATTGAA	0.338													15	31					0	0	0	0	G	144467996	G	G	144467996	3	3	189	1	0	0	0	0	1	0	0	0	14835	333	12	5	2666	5	SMARCA5	4	144467996	Missense_Mutation	SNP	A	TCGA-CV-6433-01A-11D-1683-08	70504205	144467996	46686280	18	34848											
TRIM2	23321	broad.mit.edu	37	chr4	154249705	154249705	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttaatcaggaaggagaattCatgttgaagtttggctcaaa	14	13	10	4	0	3	2	3	1	0	1	3	4	3	3	0	3	0	3	0	3	5	5			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:154249705C>T	uc003ing.2	+	11	2166	c.1965C>T	c.(1963-1965)TTC>TTT	p.F655F	TRIM2_uc003inh.2_Silent_p.F682F	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	655						cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		AAGGAGAATTCATGTTGAAGT	0.343													15	30					0	0	0	0	T	154249705	T	T	154249705	2	4	189	1	0	0	0	0	0	0	0	1	16561	825	29	2		2	TRIM2	4	154249705	Silent	SNP	C	TCGA-CV-6433-01A-11D-1683-08	9781709	154249705	36904571	19	34849											
ZNF608	57507	broad.mit.edu	37	chr5	123977043	123977043	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggccgaagggggagtggCgatccctttccctttctgcc	4	10	14	13	2	1	0	0	0	1	0	3	3	3	1	4	4	1	1	4	4	1	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr5:123977043C>T	uc003ktq.1	-	7	4475	c.4352G>A	c.(4351-4353)CGC>CAC	p.R1451H	ZNF608_uc003ktr.1_Intron|ZNF608_uc003ktp.1_Missense_Mutation_p.R146H	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1451						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GGGGGAGTGGCGATCCCTTTC	0.557													4	76					0	0	0	0	T	123977043	T	T	123977043	3	4	189	1	0	0	0	0	1	0	0	0	18101	768	27	1	198	1	ZNF608	5	123977043	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08		123977043	56938217	20	34850											
PCDHGB6	56100	broad.mit.edu	37	chr5	140788902	140788902	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acgggatctggatttcggagGaaatggagaagtcaggtgta	12	9	16	4	2	2	1	1	0	1	1	3	6	2	5	0	6	0	1	0	6	3	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr5:140788902G>C	uc003lkj.1	+	1	1133	c.1133G>C	c.(1132-1134)GGA>GCA	p.G378A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.G378A	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	378	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATTTCGGAGGAAATGGAGAA	0.413													19	21					0	0	0	0	C	140788902	C	C	140788902	3	2	189	1	0	0	0	0	1	0	0	0	11621	1174	41	2	1135	2	PCDHGB6	5	140788902	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	16811859	140788902	40126358	21	34851											
NMUR2	56923	broad.mit.edu	37	chr5	151784417	151784417	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggaggtcagagaccgccagGctgaagaggtagtagttggt	11	7	17	6	1	1	3	1	1	0	2	1	5	1	4	2	5	0	4	2	5	3	3			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr5:151784417G>T	uc003luv.2	-	1	424	c.258C>A	c.(256-258)AGC>AGA	p.S86R		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	86	Helical; Name=2; (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			AGACCGCCAGGCTGAAGAGGT	0.572													30	68					1.99505e-19	2.44464e-19	1	0	T	151784417	T	T	151784417	3	4	189	1	0	0	0	0	1	0	0	0	10561	1194	42	4	1005	4	NMUR2	5	151784417	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	10995515	151784417	29130843	22	34852											
DSP	1832	broad.mit.edu	37	chr6	7571657	7571657	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gattacatgaagacgatagcCgaccttgagttacattacca	14	10	8	9	2	0	3	0	2	0	1	0	6	0	3	3	0	4	1	3	0	5	5	rs139095230		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:7571657C>T	uc003mxp.1	+	14	2022	c.1743C>T	c.(1741-1743)GCC>GCT	p.A581A	DSP_uc003mxq.1_Silent_p.A581A	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	581	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGACGATAGCCGACCTTGAGT	0.443													6	237					0	0	0	0	T	7571657	T	T	7571657	2	4	189	1	0	0	0	0	0	0	0	1	4803	639	23	1		1	DSP	6	7571657	Silent	SNP	C	TCGA-CV-6433-01A-11D-1683-08		7571657	163543410	23	34853											
IP6K3	117283	broad.mit.edu	37	chr6	33690555	33690555	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggttttccaggccaaaaataTagccagggtctggtccatcg	10	10	11	10	1	1	0	0	0	1	0	4	0	3	0	4	4	1	1	4	4	4	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:33690555T>C	uc010jvf.2	-	7	1711	c.1175A>G	c.(1174-1176)TAT>TGT	p.Y392C	IP6K3_uc003ofb.2_Missense_Mutation_p.Y392C	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	392					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						GCCAAAAATATAGCCAGGGTC	0.483													29	82					0	0	0	0	C	33690555	C	C	33690555	3	2	189	1	0	0	0	0	1	0	0	0	7829	1406	49	5	61	5	IP6K3	6	33690555	Missense_Mutation	SNP	T	TCGA-CV-6433-01A-11D-1683-08	26118898	33690555	137424512	24	34854											
KIAA1009	22832	broad.mit.edu	37	chr6	84862866	84862866	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatttgcaggcaagtagctgCtcctgctgctctagtctttg	7	14	10	10	0	2	0	0	0	2	0	3	0	3	0	1	1	5	7	1	1	4	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:84862866C>A	uc010kbp.2	-	23	3124	c.3027G>T	c.(3025-3027)GAG>GAT	p.E1009D	KIAA1009_uc003pkj.3_Missense_Mutation_p.E933D|KIAA1009_uc003pki.3_Missense_Mutation_p.E395D	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	1009	Potential.				cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CAAGTAGCTGCTCCTGCTGCT	0.428													5	14					0.00116845	0.00130327	1	0	A	84862866	A	A	84862866	3	1	189	1	0	0	0	0	1	0	0	0	8242	796	28	4	1204	4	KIAA1009	6	84862866	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	51172311	84862866	86252201	25	34855											
ZNF292	23036	broad.mit.edu	37	chr6	87968193	87968193	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taagtggtcctcagaacacaAgatccagtcatttaaataaa	17	10	6	8	0	2	2	2	0	0	2	4	2	4	2	2	1	1	0	2	1	7	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:87968193A>G	uc003plm.3	+	8	4887	c.4846A>G	c.(4846-4848)AGA>GGA	p.R1616G		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TCAGAACACAAGATCCAGTCA	0.393													7	21					0	0	0	0	G	87968193	G	G	87968193	3	3	189	1	0	0	0	0	1	0	0	0	17893	64	3	5	4876	5	ZNF292	6	87968193	Missense_Mutation	SNP	A	TCGA-CV-6433-01A-11D-1683-08	3105327	87968193	83146874	26	34856											
FRK	2444	broad.mit.edu	37	chr6	116288718	116288718	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttattgttctcgcacctggTtttaatgttttcactgctac	6	20	6	9	1	2	0	1	0	1	0	3	0	2	0	1	1	2	5	1	1	3	9			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:116288718T>C	uc003pwi.1	-	4	1242	c.795A>G	c.(793-795)AAA>AAG	p.K265K		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	265	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TCGCACCTGGTTTTAATGTTT	0.403													9	126					0	0	0	0	C	116288718	C	C	116288718	2	2	189	1	0	0	0	0	0	0	0	1	6082	1722	60	5		5	FRK	6	116288718	Silent	SNP	T	TCGA-CV-6433-01A-11D-1683-08	28320525	116288718	54826349	27	34857											
UTRN	7402	broad.mit.edu	37	chr6	145093097	145093097	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaatgaccgaactctttcaAtcccttggtaagtgttatta	13	14	6	8	1	2	1	1	1	1	0	3	2	3	1	2	1	1	2	2	1	7	5			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:145093097A>G	uc003qkt.2	+	58	8642	c.8550A>G	c.(8548-8550)CAA>CAG	p.Q2850Q		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2850	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AACTCTTTCAATCCCTTGGTA	0.249													17	44					0	0	0	0	G	145093097	G	G	145093097	2	3	189	1	0	0	0	0	0	0	0	1	17171	98	4	5		5	UTRN	6	145093097	Silent	SNP	A	TCGA-CV-6433-01A-11D-1683-08	28804379	145093097	26021970	28	34858											
ARID1B	57492	broad.mit.edu	37	chr6	157502235	157502235	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggctctcctgtctcaagtCtgcctgccgtgggcaagaag	7	9	13	12	1	3	1	1	0	3	1	5	2	3	1	3	2	2	2	3	2	3	0			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:157502235C>G	uc003qqn.2	+	12	3366	c.3214C>G	c.(3214-3216)CTG>GTG	p.L1072V	ARID1B_uc003qqo.2_Missense_Mutation_p.L1032V|ARID1B_uc003qqp.2_Missense_Mutation_p.L1019V|ARID1B_uc010kjl.2_Missense_Mutation_p.L217V	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1077	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TGTCTCAAGTCTGCCTGCCGT	0.577													7	21					0	0	0	0	G	157502235	G	G	157502235	3	3	189	1	0	0	0	0	1	0	0	0	914	912	32	2	3314	2	ARID1B	6	157502235	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	12409138	157502235	13612832	29	34859											
MUC17	140453	broad.mit.edu	37	chr7	100677648	100677648	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctagtgaaggaacgactcCattaacaagcacacctgtca	14	8	7	12	1	1	1	1	1	0	0	3	3	3	2	3	1	3	1	3	1	5	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr7:100677648C>A	uc003uxp.1	+	3	3004	c.2951C>A	c.(2950-2952)CCA>CAA	p.P984Q	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	984	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|14.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGAACGACTCCATTAACAAGC	0.507													92	160					1.01459e-35	1.261e-35	1	0	A	100677648	A	A	100677648	3	1	189	1	0	0	0	0	1	0	0	0	10027	594	21	4	2961	4	MUC17	7	100677648	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08		100677648	58461015	30	34860											
OR2A14	135941	broad.mit.edu	37	chr7	143826964	143826964	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgggactcttctttggcagCgccattgtcacgtacatggc	6	12	12	11	2	3	0	1	0	2	0	3	1	3	1	1	3	2	2	1	3	1	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr7:143826964C>T	uc011kua.1	+	1	759	c.759C>T	c.(757-759)AGC>AGT	p.S253S		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TCTTTGGCAGCGCCATTGTCA	0.577													4	136					0	0	0	0	T	143826964	T	T	143826964	2	4	189	1	0	0	0	0	0	0	0	1	11030	767	27	1		1	OR2A14	7	143826964	Silent	SNP	C	TCGA-CV-6433-01A-11D-1683-08	43149316	143826964	15311699	31	34861											
PDGFRL	5157	broad.mit.edu	37	chr8	17478590	17478590	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgagcgctacggccagttGactctggtcaactccacctc	9	9	9	14	2	2	2	1	2	1	0	4	2	3	2	3	2	3	2	3	2	3	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:17478590G>T	uc003wxr.2	+	3	445	c.384G>T	c.(382-384)TTG>TTT	p.L128F		NM_006207	NP_006198	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	128	Ig-like C2-type 1.					extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity				0				Colorectal(111;0.0752)		ACGGCCAGTTGACTCTGGTCA	0.567													13	35					1.05317e-09	1.25515e-09	1	0	T	17478590	T	T	17478590	3	4	189	1	0	0	0	0	1	0	0	0	11717	1281	45	2	394	2	PDGFRL	8	17478590	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08		17478590	128885432	32	34862											
POLR3D	661	broad.mit.edu	37	chr8	22107661	22107661	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggttggcaagctactcatccGcaagtctggaagggtgcaac	10	8	13	10	1	2	0	1	0	1	0	3	1	3	1	1	4	4	5	1	4	5	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:22107661G>A	uc003xbl.2	+	8	1078	c.995G>A	c.(994-996)CGC>CAC	p.R332H	POLR3D_uc003xbm.2_Missense_Mutation_p.R332H|POLR3D_uc011kze.1_RNA	NM_001722	NP_001713	P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	332					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity				0				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CTACTCATCCGCAAGTCTGGA	0.562													4	56					0	0	0	0	A	22107661	A	A	22107661	3	1	189	1	0	0	0	0	1	0	0	0	12286	1087	38	1	1021	1	POLR3D	8	22107661	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	4629071	22107661	124256361	33	34863											
CHRNA2	1135	broad.mit.edu	37	chr8	27327422	27327422	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcggtatgcgagcctccctgCggcaatgccgtgggactggg	5	8	16	12	4	0	0	0	0	0	0	2	2	1	1	3	4	4	2	3	4	2	1			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:27327422C>T	uc010lur.2	-	3	759	c.150G>A	c.(148-150)CCG>CCA	p.P50P	CHRNA2_uc011lal.1_Silent_p.P50P|CHRNA2_uc010lus.2_5'UTR	NM_000742	NP_000733	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha	50	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)	1		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine(DB01336)|Metocurine Iodide(DB00416)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	AGCCTCCCTGCGGCAATGCCG	0.612													5	84					0	0	0	0	T	27327422	T	T	27327422	2	4	189	1	0	0	0	0	0	0	0	1	3398	755	27	1		1	CHRNA2	8	27327422	Silent	SNP	C	TCGA-CV-6433-01A-11D-1683-08	5219761	27327422	119036600	34	34864											
LRRC67	286187	broad.mit.edu	37	chr8	67929968	67929968	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttctggcaattagatccaaGgtcagtcgaaccataatttc	12	13	7	9	1	2	1	1	0	1	1	5	2	3	1	2	2	1	1	2	2	5	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:67929968G>T	uc003xxc.2	-	2	160	c.15C>A	c.(13-15)ACC>ACA	p.T5T		NM_001013626	NP_001013648	Q7Z4L9	LRC67_HUMAN	leucine rich repeat containing 67	5											0						TTAGATCCAAGGTCAGTCGAA	0.338													14	56					0.000219431	0.00025798	1	0	T	67929968	T	T	67929968	2	4	189	1	0	0	0	0	0	0	0	1	9069	987	35	4		4	LRRC67	8	67929968	Silent	SNP	G	TCGA-CV-6433-01A-11D-1683-08	40602546	67929968	78434054	35	34865											
FABP4	2167	broad.mit.edu	37	chr8	82392828	82392828	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cactttcctggtggcaaagcCcactcctacagttaggaaaa	12	9	8	12	0	0	0	0	0	0	0	2	1	2	1	3	3	2	2	3	3	5	3			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:82392828C>G	uc003ycd.2	-	2	150	c.79G>C	c.(79-81)GGC>CGC	p.G27R		NM_001442	NP_001433	P15090	FABP4_HUMAN	fatty acid binding protein 4, adipocyte	27	Nuclear localization signal (By similarity).				triglyceride catabolic process	cytoplasm|nucleus|soluble fraction	fatty acid binding|protein binding|transporter activity			breast(1)	1			Epithelial(68;0.213)			GTGGCAAAGCCCACTCCTACA	0.423													3	54					0	0	0	0	G	82392828	G	G	82392828	3	3	189	1	0	0	0	0	1	0	0	0	5387	623	22	4	331	4	FABP4	8	82392828	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	14462860	82392828	63971194	36	34866											
SYBU	55638	broad.mit.edu	37	chr8	110587412	110587412	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatccagctctctcatgaggCggtttgcatgaacttctgca	9	12	9	11	1	3	2	1	2	2	0	5	2	4	2	1	2	4	4	1	2	2	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:110587412C>T	uc003ynj.3	-	7	1878	c.1715G>A	c.(1714-1716)CGC>CAC	p.R572H	SYBU_uc003yni.3_Missense_Mutation_p.R569H|SYBU_uc003ynk.3_Missense_Mutation_p.R453H|SYBU_uc010mco.2_Missense_Mutation_p.R571H|SYBU_uc003ynl.3_Missense_Mutation_p.R571H|SYBU_uc010mcp.2_Missense_Mutation_p.R572H|SYBU_uc010mcq.2_Missense_Mutation_p.R572H|SYBU_uc003yno.3_Missense_Mutation_p.R453H|SYBU_uc010mcr.2_Missense_Mutation_p.R572H|SYBU_uc003ynm.3_Missense_Mutation_p.R571H|SYBU_uc003ynn.3_Missense_Mutation_p.R571H|SYBU_uc010mcs.2_Missense_Mutation_p.R453H|SYBU_uc010mct.2_Missense_Mutation_p.R572H|SYBU_uc010mcu.2_Missense_Mutation_p.R571H|SYBU_uc003ynp.3_Missense_Mutation_p.R504H|SYBU_uc010mcv.2_Missense_Mutation_p.R572H|SYBU_uc003ynh.3_Missense_Mutation_p.R366H|SYBU_uc011lhw.1_Missense_Mutation_p.R442H	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	572						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						TCTCATGAGGCGGTTTGCATG	0.542													19	37					0	0	0	0	T	110587412	T	T	110587412	3	4	189	1	0	0	0	0	1	0	0	0	15493	768	27	1	280	1	SYBU	8	110587412	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	28194584	110587412	35776610	37	34867											
CSMD3	114788	broad.mit.edu	37	chr8	113933928	113933928	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgacaggtgatgctctttgCgccctgtaggacataatctt	8	14	10	9	1	2	2	0	2	2	0	2	3	2	3	1	2	2	2	1	2	2	5	rs140758499		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:113933928C>T	uc003ynu.2	-	10	1720	c.1561G>A	c.(1561-1563)GCA>ACA	p.A521T	CSMD3_uc003ynt.2_Missense_Mutation_p.A481T|CSMD3_uc011lhx.1_Missense_Mutation_p.A417T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	521	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATGCTCTTTGCGCCCTGTAGG	0.383										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			33	53					0	0	0	0	T	113933928	T	T	113933928	3	4	189	1	0	0	0	0	1	0	0	0	3963	768	27	1	9810	1	CSMD3	8	113933928	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	3346516	113933928	32430094	38	34868											
GPIHBP1	338328	broad.mit.edu	37	chr8	144295190	144295190	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccctcttgctgtgcgggcgGccaggtgcggggcaaagggt	4	7	19	11	3	1	0	0	0	1	0	1	0	1	0	2	6	3	2	2	6	1	1			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:144295190G>T	uc003yxu.1	+	1	123	c.48G>T	c.(46-48)CGG>CGT	p.R16R		NM_178172	NP_835466	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high	16					cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity				0	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGTGCGGGCGGCCAGGTGCGG	0.672													3	23					0.00909568	0.00965029	1	0	T	144295190	T	T	144295190	2	4	189	1	0	0	0	0	0	0	0	1	6650	1190	42	4		4	GPIHBP1	8	144295190	Silent	SNP	G	TCGA-CV-6433-01A-11D-1683-08	30361262	144295190	2068832	39	34869											
ZNF658	26149	broad.mit.edu	37	chr9	40774007	40774007	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgaataggatgtgaacttGaacaaaaggattttgcacat	15	11	10	5	0	0	3	0	3	0	0	0	5	0	5	0	2	3	2	0	2	6	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:40774007G>T	uc004abs.2	-	5	1420	c.1268C>A	c.(1267-1269)TCA>TAA	p.S423*	ZNF658_uc010mmm.1_Nonsense_Mutation_p.S423*|ZNF658_uc010mmn.1_Nonsense_Mutation_p.S423*	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	423	C2H2-type 4; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ATGTGAACTTGAACAAAAGGA	0.398													6	181					0.00116845	0.00130327	1	0	T	40774007	T	T	40774007	4	4	189	1	0	0	0	0	0	1	0	0	18136	1294	45	2	1915	2	ZNF658	9	40774007	Nonsense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08		40774007	100439424	40	34870											
TDRD7	23424	broad.mit.edu	37	chr9	100222899	100222899	+	Frame_Shift_Del	DEL	A	-	-																															tatcaaggctatggttgaacAagagtatttgcaggtagaag																										TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:100222899delA	uc004axj.2	+	7	1520	c.1295delA	c.(1294-1296)CAAfs	p.Q432fs	TDRD7_uc011lux.1_Frame_Shift_Del_p.Q358fs	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	432	Lotus/OST-HTH 3.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				ATGGTTGAACAAGAGTATTTG	0.408													---	---	---								-	100222899	-	-	100222899	7	5	189	1	0	1	0	1	0	0	0	0	15801	130	5	0	1317	0	TDRD7	9	100222899	Frame_Shift_Del	DEL	A	TCGA-CV-6433-01A-11D-1683-08	59448892	100222899	40990532	41	34871											
ABCA1	19	broad.mit.edu	37	chr9	107593339	107593339	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagcccccccagacgtaccGcatgtcctcaaaggggtcag	10	5	11	15	2	2	1	2	0	0	1	3	2	3	1	5	2	2	2	5	2	3	1	rs2853574		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:107593339G>A	uc004bcl.2	-	14	2072	c.1759C>T	c.(1759-1761)CGG>TGG	p.R587W		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	587	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGACGTACCGCATGTCCTCA	0.502													4	94					0	0	0	0	A	107593339	A	A	107593339	3	1	189	1	0	0	0	0	1	0	0	0	28	1086	38	1	5174	1	ABCA1	9	107593339	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	7370440	107593339	33620092	42	34872											
UAP1L1	91373	broad.mit.edu	37	chr9	139974547	139974547	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtaaagccgctaaaaccgaaCgggataaagatggagaagtt	17	6	12	6	3	0	2	0	0	0	2	0	5	0	3	2	2	3	3	2	2	8	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:139974547C>T	uc010ncb.2	+	6	1163	c.1131C>T	c.(1129-1131)AAC>AAT	p.N377N	UAP1L1_uc004cla.3_Silent_p.N254N	NM_207309	NP_997192	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like	377							nucleotidyltransferase activity			ovary(1)	1	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		TAAAACCGAACGGGATAAAGA	0.473													51	59					0	0	0	0	T	139974547	T	T	139974547	2	4	189	1	0	0	0	0	0	0	0	1	16894	535	19	1		1	UAP1L1	9	139974547	Silent	SNP	C	TCGA-CV-6433-01A-11D-1683-08	32381208	139974547	1238884	43	34873											
PRKG1	5592	broad.mit.edu	37	chr10	53564372	53564372	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaatgtaaaactctgggccaTtgatcgacaatgttttcaaa	15	12	7	7	1	2	1	1	1	1	0	3	2	2	1	1	1	1	2	1	1	5	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr10:53564372T>A	uc001jjm.2	+	4	769	c.575T>A	c.(574-576)ATT>AAT	p.I192N	PRKG1_uc001jjn.2_Missense_Mutation_p.I207N|PRKG1_uc001jjo.2_Missense_Mutation_p.I207N	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	192	cGMP 1.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		CTCTGGGCCATTGATCGACAA	0.343													12	36					0	0	0	0	A	53564372	A	A	53564372	3	1	189	1	0	0	0	0	1	0	0	0	12584	1493	52	5	904	5	PRKG1	10	53564372	Missense_Mutation	SNP	T	TCGA-CV-6433-01A-11D-1683-08		53564372	81970375	44	34874											
GFRA1	2674	broad.mit.edu	37	chr10	117823944	117823944	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaagataatagggtggacaGagcggttaccaccaggacca	15	6	12	8	1	0	2	0	0	0	2	0	4	0	4	3	4	2	1	3	4	5	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr10:117823944G>A	uc001lcj.2	-	11	2061	c.1363C>T	c.(1363-1365)CTG>TTG	p.L455L	GFRA1_uc001lci.2_Silent_p.L450L|GFRA1_uc009xyr.2_Silent_p.L450L	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	455					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		AGGGTGGACAGAGCGGTTACC	0.428													12	36					0	0	0	0	A	117823944	A	A	117823944	2	1	189	1	0	0	0	0	0	0	0	1	6384	933	33	2		2	GFRA1	10	117823944	Silent	SNP	G	TCGA-CV-6433-01A-11D-1683-08	64259572	117823944	17710803	45	34875											
OR4C11	219429	broad.mit.edu	37	chr11	55371281	55371281	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcaggttgatcatgtaaGtgtccatgcaggcaagtttc	11	11	11	8	0	1	1	1	1	0	0	3	1	2	1	1	2	2	6	1	2	2	3			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr11:55371281G>A	uc010rii.1	-	1	569	c.569C>T	c.(568-570)ACT>ATT	p.T190I		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GATCATGTAAGTGTCCATGCA	0.398													60	46					0	0	0	0	A	55371281	A	A	55371281	3	1	189	1	0	0	0	0	1	0	0	0	11099	1029	36	4	365	4	OR4C11	11	55371281	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08		55371281	79635235	46	34876											
RPS6KB2	6199	broad.mit.edu	37	chr11	67200832	67200832	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcccttcaccgcagagaacCggaagaaaaccatggataag	15	4	10	12	3	1	2	1	0	0	2	1	5	1	4	4	2	2	1	4	2	5	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr11:67200832C>T	uc001old.2	+	10	902	c.820C>T	c.(820-822)CGG>TGG	p.R274W	RPS6KB2_uc001olf.2_Missense_Mutation_p.R74W|RPS6KB2_uc001olg.2_Missense_Mutation_p.R274W|RPS6KB2_uc009yrq.2_Missense_Mutation_p.R74W|RPS6KB2_uc001ole.2_RNA|RPS6KB2_uc001olh.2_Intron|RPS6KB2_uc009yrr.2_Missense_Mutation_p.R105W	NM_003952	NP_003943	Q9UBS0	KS6B2_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide	274	Protein kinase.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of translational initiation|translation	nucleoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|stomach(1)|lung(1)|salivary_gland(1)	7			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CGCAGAGAACCGGAAGAAAAC	0.632													11	78					0	0	0	0	T	67200832	T	T	67200832	3	4	189	1	0	0	0	0	1	0	0	0	13722	643	23	1	858	1	RPS6KB2	11	67200832	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	11829551	67200832	67805684	47	34877											
CUX2	23316	broad.mit.edu	37	chr12	111652070	111652070	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagtgaacattctcataaaCatttaattgaactccgccgg	14	11	7	9	2	1	3	1	2	1	1	3	3	2	3	2	1	3	0	2	1	5	5			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr12:111652070C>A	uc001tsa.1	+	2	283	c.130C>A	c.(130-132)CAT>AAT	p.H44N	CUX2_uc001tsb.1_Missense_Mutation_p.H99N	NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	44						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TTCTCATAAACATTTAATTGA	0.363													4	101					0.00024832	0.000284261	1	0	A	111652070	A	A	111652070	3	1	189	1	0	0	0	0	1	0	0	0	4082	478	17	4	136	4	CUX2	12	111652070	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08		111652070	22199825	48	34878											
KIAA1409	57578	broad.mit.edu	37	chr14	94046720	94046721	+	Frame_Shift_Del	DEL	GT	-	-																															ctaaagaagaaagccggctgGtggtaagcagttgaagaaac																										TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr14:94046720_94046721delGT	uc001ybv.1	+	16	2211_2212	c.2128_2129delGT	c.(2128-2130)GTGfs	p.V710fs	KIAA1409_uc001ybs.1_Frame_Shift_Del_p.V710fs	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	887						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AAGCCGGCTGGTGGTAAGCAGT	0.441													---	---	---								-	94046721	-	-	94046720	7	5	189	1	0	1	0	1	0	0	0	0	8269	1261	44	0	2190	0	KIAA1409	14	94046720	Frame_Shift_Del	DEL	GT	TCGA-CV-6433-01A-11D-1683-08		94046720	13302820	49	34879											
STRC	161497	broad.mit.edu	37	chr15	43900125	43900126	+	Missense_Mutation	DNP	GT	TC	TC																															ccctacagttgtccattctgGttctggcattgccatcctcc																										TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr15:43900125_43900126GT>TC	uc001zsf.2	-	18	3807_3808	c.3729_3730AC>GA	c.(3727-3732)GAACCA>GAGACA	p.P1244T	STRC_uc010bdl.2_Missense_Mutation_p.P471T|STRC_uc001zse.2_5'UTR	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1244					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GTCCATTCTGGTTCTGGCATTG	0.535													22	95					0	0	0	0	TC	43900126	TC	TC	43900125	3	4	189	1	0	0	0	0	1	0	0	0	15394	1261	44	4	1645	4	STRC	15	43900125	Missense_Mutation	DNP	GT	TCGA-CV-6433-01A-11D-1683-08		43900125	58631267	50	34880											
SCG3	29106	broad.mit.edu	37	chr15	51981445	51981445	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agccaagcacatacactggaAgatgaagtagcagaggtttt	15	8	11	7	0	0	3	0	1	0	2	0	4	0	4	1	2	4	4	1	2	5	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr15:51981445A>G	uc002abh.2	+	6	978	c.570A>G	c.(568-570)GAA>GAG	p.E190E	SCG3_uc010ufz.1_5'UTR	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	190					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		ATACACTGGAAGATGAAGTAG	0.368													25	43					0	0	0	0	G	51981445	G	G	51981445	2	3	189	1	0	0	0	0	0	0	0	1	13957	69	3	5		5	SCG3	15	51981445	Silent	SNP	A	TCGA-CV-6433-01A-11D-1683-08	8081320	51981445	50549947	51	34881											
ZNF609	23060	broad.mit.edu	37	chr15	64967739	64967739	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccatattaccaaggctttGagagttactattctccaagt	12	13	6	10	0	1	1	0	1	1	1	2	2	1	1	3	1	2	2	3	1	6	6			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr15:64967739G>A	uc002ann.2	+	4	2686	c.2686G>A	c.(2686-2688)GAG>AAG	p.E896K		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	896						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCAAGGCTTTGAGAGTTACTA	0.507													5	97					0	0	0	0	A	64967739	A	A	64967739	3	1	189	1	0	0	0	0	1	0	0	0	18102	1291	45	2	2700	2	ZNF609	15	64967739	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	12986294	64967739	37563653	52	34882											
CDH11	1009	broad.mit.edu	37	chr16	64984710	64984710	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgaggatggcgatcagggcGcctgtgctcaggccggcgtt	5	7	18	11	5	2	0	2	0	0	0	2	3	2	1	2	5	1	2	2	5	0	1			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr16:64984710G>A	uc002eoi.2	-	12	2288	c.1854C>T	c.(1852-1854)GGC>GGT	p.G618G	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.G618G|CDH11_uc010vin.1_Silent_p.G492G	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	618	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CGATCAGGGCGCCTGTGCTCA	0.632			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			9	27					0	0	0	0	A	64984710	A	A	64984710	2	1	189	1	0	0	0	0	0	0	0	1	3112	1074	38	1		1	CDH11	16	64984710	Silent	SNP	G	TCGA-CV-6433-01A-11D-1683-08		64984710	25370043	53	34883											
CES2	8824	broad.mit.edu	37	chr16	66974469	66974469	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accatttttggcgagtctgcGggtggcacgagtgtgtcttc	5	13	14	9	3	2	0	0	0	2	0	3	2	2	0	1	3	1	1	1	3	0	3	rs150055059		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr16:66974469G>A	uc002eqr.2	+	5	1879	c.879G>A	c.(877-879)GCG>GCA	p.A293A	CES2_uc002eqq.2_Silent_p.A293A|CES2_uc002eqs.2_Silent_p.A136A	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	229					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		GCGAGTCTGCGGGTGGCACGA	0.607													35	70					0	0	0	0	A	66974469	A	A	66974469	2	1	189	1	0	0	0	0	0	0	0	1	3285	1103	39	1		1	CES2	16	66974469	Silent	SNP	G	TCGA-CV-6433-01A-11D-1683-08	1989759	66974469	23380284	54	34884											
KCNH6	81033	broad.mit.edu	37	chr17	61601637	61601645	+	In_Frame_Del	DEL	CCCAACACA	-	-																															cctgcgacttcctcacaggcCccaacacaccaagcagcgcc																								rs143633824		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr17:61601637_61601645delCCCAACACA	uc002jay.2	+	2	294_302	c.214_222delCCCAACACA	c.(214-222)CCCAACACAdel	p.PNT72del	KCNH6_uc002jax.1_In_Frame_Del_p.PNT72del|KCNH6_uc010wpl.1_Intron|KCNH6_uc010wpm.1_In_Frame_Del_p.PNT72del|KCNH6_uc002jaz.1_In_Frame_Del_p.PNT72del	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	72_74	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCTCACAGGCCCCAACACACCAAGCAGCG	0.612													---	---	---								-	61601645	-	-	61601637	7	5	189	1	0	1	0	1	0	0	0	0	8075	623	22	0	220	0	KCNH6	17	61601637	In_Frame_Del	DEL	CCCAACACA	TCGA-CV-6433-01A-11D-1683-08		61601637	19593573	55	34885											
KIAA1012	22878	broad.mit.edu	37	chr18	29432467	29432467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttcagaggactgtgtggccGctaaaaaacaggggaaaaca	15	7	12	7	1	1	1	1	0	0	1	1	3	1	3	1	4	2	1	1	4	5	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr18:29432467G>A	uc002kxc.3	-	24	3867	c.3503C>T	c.(3502-3504)GCG>GTG	p.A1168V	KIAA1012_uc002kxb.3_Missense_Mutation_p.A1114V|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1168					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						CTGTGTGGCCGCTAAAAAACA	0.318													4	186					0	0	0	0	A	29432467	A	A	29432467	3	1	189	1	0	0	0	0	1	0	0	0	8243	1101	38	1	828	1	KIAA1012	18	29432467	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08		29432467	48644781	56	34886											
MUC16	94025	broad.mit.edu	37	chr19	9088749	9088749	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccattcgtggtctctgttgtGaggatggttgttgatggttc	4	17	14	6	1	1	2	0	2	1	0	4	3	1	3	1	4	0	4	1	4	0	5			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:9088749G>C	uc002mkp.2	-	1	3270	c.3066C>G	c.(3064-3066)CTC>CTG	p.L1022L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1022	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTCTGTTGTGAGGATGGTTG	0.473													9	144					0	0	0	0	C	9088749	C	C	9088749	2	2	189	1	0	0	0	0	0	0	0	1	10026	1277	45	2		2	MUC16	19	9088749	Silent	SNP	G	TCGA-CV-6433-01A-11D-1683-08		9088749	50040234	57	34887											
GCDH	2639	broad.mit.edu	37	chr19	13004312	13004312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	accaggatatggctgtgctgGggtttcgtctgtggcctatg	5	13	15	8	1	1	0	0	0	1	0	2	1	1	1	2	5	1	3	2	5	2	3			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:13004312G>A	uc002mvq.2	+	6	427	c.350G>A	c.(349-351)GGG>GAG	p.G117E	GCDH_uc010xms.1_Missense_Mutation_p.G84E|GCDH_uc002mvp.2_Missense_Mutation_p.G117E|GCDH_uc010xmt.1_5'UTR|GCDH_uc010xmu.1_Missense_Mutation_p.G73E	NM_000159	NP_000150	Q92947	GCDH_HUMAN	glutaryl-Coenzyme A dehydrogenase isoform a	117					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0						GGCTGTGCTGGGGTTTCGTCT	0.597													25	27					0	0	0	0	A	13004312	A	A	13004312	3	1	189	1	0	0	0	0	1	0	0	0	6322	1232	43	4	368	4	GCDH	19	13004312	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	3915563	13004312	46124671	58	34888											
CIB3	117286	broad.mit.edu	37	chr19	16284287	16284287	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actgtctgcttgttgcccatGgtgtgaaccacagcccagac	8	10	10	13	0	1	2	0	1	1	1	1	2	1	2	3	1	4	2	3	1	1	2			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:16284287G>A	uc002nds.2	-	1	1	c.1_splice	c.e1-1	p.M1_splice	CIB3_uc010eae.2_Splice_Site|CIB3_uc010eaf.2_Splice_Site|CIB3_uc010eag.2_Splice_Site_p.M1_splice	NM_054113	NP_473454	Q96Q77	CIB3_HUMAN	DNA-dependent protein kinase catalytic								calcium ion binding			ovary(1)	1						TGTTGCCCATGGTGTGAACCA	0.587													3	86					0	0	0	0	A	16284287	A	A	16284287	5	1	189	1	0	0	0	0	0	0	1	0	3437	1363	47	4	587	4	CIB3	19	16284287	Splice_Site	SNP	G	TCGA-CV-6433-01A-11D-1683-08	3279975	16284287	42844696	59	34889											
FAM125A	93343	broad.mit.edu	37	chr19	17529186	17529200	+	5'Flank	DEL	TATTATTATTATTAT	-	-																															ccaatgggtgtaaaaaagcaTattattattattattattat																								rs5827375		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:17529186_17529200delTATTATTATTATTAT	uc002ngo.1	+						FAM125A_uc002ngn.1_5'Flank|FAM125A_uc002ngp.1_5'Flank	NM_138401	NP_612410	Q96EY5	F125A_HUMAN	family with sequence similarity 125, member A						protein transport	late endosome membrane|microtubule organizing center|nucleus	SH3 domain binding				0						TAAAAAAGCAtattattattattattattattatt	0.205													---	---	---								-	17529200	-	-	17529186	6	5	189	0	1	1	0	1	0	0	0	0	5455	1421	49	0		0	FAM125A	19	17529186	5'Flank	DEL	TATTATTATTATTAT	TCGA-CV-6433-01A-11D-1683-08	1244899	17529186	41599797	60	34890											
ELL	8178	broad.mit.edu	37	chr19	18555654	18555654	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtactcgcagcggtgctTctcctggctgtagttggtgt	4	13	14	10	2	1	0	0	0	1	0	3	0	1	0	1	4	3	6	1	4	2	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:18555654T>A	uc002njh.2	-	12	1846	c.1774A>T	c.(1774-1776)AAG>TAG	p.K592*	ELL_uc010ebq.2_Nonsense_Mutation_p.K535*|ELL_uc002njg.2_Nonsense_Mutation_p.K459*	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	592					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)		CAGCGGTGCTTCTCCTGGCTG	0.642			T	MLL	AL								16	41					0	0	0	0	A	18555654	A	A	18555654	4	1	189	1	0	0	0	0	0	1	0	0	5086	1792	62	5	95	5	ELL	19	18555654	Nonsense_Mutation	SNP	T	TCGA-CV-6433-01A-11D-1683-08	1026468	18555654	40573329	61	34891											
CILP2	148113	broad.mit.edu	37	chr19	19654650	19654659	+	Frame_Shift_Del	DEL	CGCCAGCTCC	-	-																															tccagcccccgctgcggggaCgccagctcccgctgctgctc																										TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:19654650_19654659delCGCCAGCTCC	uc002nmv.3	+	8	1381_1390	c.1296_1305delCGCCAGCTCC	c.(1294-1305)GACGCCAGCTCCfs	p.D432fs	CILP2_uc002nmw.3_Frame_Shift_Del_p.D438fs	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	432_435						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GCTGCGGGGACGCCAGCTCCCGCTGCTGCT	0.671													---	---	---								-	19654659	-	-	19654650	7	5	189	1	0	1	0	1	0	0	0	0	3445	535	19	0	1326	0	CILP2	19	19654650	Frame_Shift_Del	DEL	CGCCAGCTCC	TCGA-CV-6433-01A-11D-1683-08	1098996	19654650	39474333	62	34892			1	50		2	2	17	N	T_CGCCAGCTCC	3.772936e-05
CILP2	148113	broad.mit.edu	37	chr19	19654666	19654666	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggacgccagctcccgctgcTgctctgtgcgccgtctggag	3	8	15	15	4	2	0	0	0	2	0	3	2	3	2	3	2	4	4	3	2	0	0			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:19654666T>G	uc002nmv.3	+	8	1397	c.1312T>G	c.(1312-1314)TGC>GGC	p.C438G	CILP2_uc002nmw.3_Missense_Mutation_p.C444G	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	438						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CTCCCGCTGCTGCTCTGTGCG	0.682													33	39					0	0	0	0	G	19654666	G	G	19654666	3	3	189	1	0	0	0	0	1	0	0	0	3445	1580	55	5	1342	5	CILP2	19	19654666	Missense_Mutation	SNP	T	TCGA-CV-6433-01A-11D-1683-08	16	19654666	39474317	63	34893			1	50		2	2	17	N	T_CGCCAGCTCC	3.772936e-05
RYR1	6261	broad.mit.edu	37	chr19	38979817	38979817	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	accgagactttgtcctgtagGtgatgggcatctttggcgat	7	13	13	8	2	1	2	0	1	1	1	2	4	2	2	2	3	0	2	2	3	1	3			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:38979817G>A	uc002oit.2	+	35	5678	c.5548G>A	c.(5548-5550)GTG>ATG	p.V1850M	RYR1_uc002oiu.2_Missense_Mutation_p.V1850M	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1850	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGTCCTGTAGGTGATGGGCAT	0.443													11	9					0	0	0	0	A	38979817	A	A	38979817	3	1	189	1	0	0	0	0	1	0	0	0	13833	1275	44	4	5686	4	RYR1	19	38979817	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	19325151	38979817	20149166	64	34894											
EXOC3L2	90332	broad.mit.edu	37	chr19	45716536	45716536	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcagagagttccaggtcccGggccacggccaggatctcct	7	7	12	15	2	2	1	1	0	1	1	5	3	4	2	5	4	0	1	5	4	0	1			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:45716536G>A	uc002pay.1	-	10	1062	c.1021C>T	c.(1021-1023)CGG>TGG	p.R341W		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	341										ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		TCCAGGTCCCGGGCCACGGCC	0.657													9	24					0	0	0	0	A	45716536	A	A	45716536	3	1	189	1	0	0	0	0	1	0	0	0	5329	1115	39	1	212	1	EXOC3L2	19	45716536	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	6736719	45716536	13412447	65	34895											
ZNF880	400713	broad.mit.edu	37	chr19	52887785	52887785	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcacgacatcagaaaattCatagtggagagaaaccttac	16	9	8	8	1	2	2	2	0	0	2	2	5	2	3	1	1	3	1	1	1	5	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:52887785C>T	uc002pzc.2	+	4	1001	c.952C>T	c.(952-954)CAT>TAT	p.H318Y		NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	318	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TCAGAAAATTCATAGTGGAGA	0.413													19	13					0	0	0	0	T	52887785	T	T	52887785	3	4	189	1	0	0	0	0	1	0	0	0	18264	826	29	2	966	2	ZNF880	19	52887785	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	7171249	52887785	6241198	66	34896											
ZNF835	90485	broad.mit.edu	37	chr19	57176313	57176313	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcgggctctccccaggcGcgctgcacctccgggaactg	4	7	12	18	4	1	0	0	0	1	0	4	1	2	1	5	3	2	3	5	3	1	1			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:57176313G>A	uc010ygo.1	-	2	320	c.320C>T	c.(319-321)GCG>GTG	p.A107V	ZNF835_uc010ygn.1_Missense_Mutation_p.A85V	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CTCCCCAGGCGCGCTGCACCT	0.647													10	17					0	0	0	0	A	57176313	A	A	57176313	3	1	189	1	0	0	0	0	1	0	0	0	18253	1087	38	1	1361	1	ZNF835	19	57176313	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	4288528	57176313	1952670	67	34897											
KIF3B	9371	broad.mit.edu	37	chr20	30897975	30897975	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcttcacccacatctctcGatcccagaatcaacaatacc	13	10	2	16	1	4	1	2	0	2	1	7	2	5	1	3	0	2	0	3	0	5	3			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr20:30897975G>T	uc002wxq.2	+	2	562	c.395G>T	c.(394-396)CGA>CTA	p.R132L	KIF3B_uc010ztv.1_Missense_Mutation_p.R132L|KIF3B_uc010ztw.1_Missense_Mutation_p.R132L	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	132	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CACATCTCTCGATCCCAGAAT	0.463													5	102					1.6384e-10	1.97973e-10	1	0	T	30897975	T	T	30897975	3	4	189	1	0	0	0	0	1	0	0	0	8340	1058	37	3	397	3	KIF3B	20	30897975	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08		30897975	32127545	68	34898											
MAPK11	5600	broad.mit.edu	37	chr22	50703752	50703752	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccactgccatgctcacccTtccactcctccagcgtgcgc	6	8	7	20	2	1	0	1	0	0	0	4	0	4	0	6	0	5	1	6	0	0	1			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr22:50703752T>C	uc003bkr.2	-	11	1071	c.1013A>G	c.(1012-1014)AAG>AGG	p.K338R	MAPK11_uc010hax.2_Missense_Mutation_p.K160R|MAPK11_uc011ars.1_RNA|MAPK11_uc010hay.1_RNA	NM_002751	NP_002742	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	338					activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			lung(1)|breast(1)	2		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ATGCTCACCCTTCCACTCCTC	0.637													3	63					0	0	0	0	C	50703752	C	C	50703752	3	2	189	1	0	0	0	0	1	0	0	0	9326	1609	56	5	89	5	MAPK11	22	50703752	Missense_Mutation	SNP	T	TCGA-CV-6433-01A-11D-1683-08		50703752	600814	69	34899											
CXorf22	170063	broad.mit.edu	37	chrX	35938046	35938046	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acatgcagctgcgggtgatcCcggctgaggtgaagttcctg	7	9	15	10	2	0	3	0	3	0	0	2	3	2	3	2	3	3	4	2	3	1	1			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:35938046C>T	uc004ddj.2	+	1	189	c.130C>T	c.(130-132)CCG>TCG	p.P44S	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	44										large_intestine(1)|lung(1)|ovary(1)	3						GCGGGTGATCCCGGCTGAGGT	0.562													5	5					0	0	0	0	T	35938046	T	T	35938046	3	4	189	1	0	0	0	0	1	0	0	0	4119	623	22	4	132	4	CXorf22	23	35938046	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08		35938046	119332514	70	34900											
TAF1	6872	broad.mit.edu	37	chrX	70613166	70613166	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtagattaaaaagttgtccCgctgggaagtgattgatgtg	11	12	13	5	2	0	3	0	2	0	1	1	4	1	4	1	1	0	3	1	1	5	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:70613166C>T	uc004dzu.3	+	21	3115	c.3064C>T	c.(3064-3066)CGC>TGC	p.R1022C	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.R1043C|TAF1_uc004dzv.3_Missense_Mutation_p.R196C	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1022					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AAAGTTGTCCCGCTGGGAAGT	0.323													24	12					0	0	0	0	T	70613166	T	T	70613166	3	4	189	1	0	0	0	0	1	0	0	0	15579	652	23	1	3209	1	TAF1	23	70613166	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	34675120	70613166	84657394	71	34901											
GPC3	2719	broad.mit.edu	37	chrX	132826430	132826430	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttgtccattccagcaaaggGtgtcgttttccgccacaggg	7	11	11	12	2	0	0	0	0	0	0	4	0	3	0	4	2	1	2	4	2	1	4			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:132826430G>A	uc004exe.1	-	5	1449	c.1259C>T	c.(1258-1260)ACC>ATC	p.T420I	GPC3_uc004exd.1_Missense_Mutation_p.T292I|GPC3_uc010nrn.1_Missense_Mutation_p.T443I|GPC3_uc011mvh.1_Missense_Mutation_p.T404I|GPC3_uc010nro.1_Missense_Mutation_p.T366I|GPC3_uc010nrp.1_Missense_Mutation_p.T292I	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	420						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					CCAGCAAAGGGTGTCGTTTTC	0.388			T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				25	10					0	0	0	0	A	132826430	A	A	132826430	3	1	189	1	0	0	0	0	1	0	0	0	6637	1261	44	4	499	4	GPC3	23	132826430	Missense_Mutation	SNP	G	TCGA-CV-6433-01A-11D-1683-08	62213264	132826430	22444130	72	34902											
MAGEC1	9947	broad.mit.edu	37	chrX	140994302	140994302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttgagggttttccccagtCtcctctccagattcctggga	5	15	9	12	0	2	2	0	1	2	1	6	3	4	3	5	2	0	1	5	2	0	5			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:140994302C>T	uc004fbt.2	+	4	1398	c.1112C>T	c.(1111-1113)TCT>TTT	p.S371F	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	371							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCCCAGTCTCCTCTCCAG	0.478										HNSCC(15;0.026)			22	72					0	0	0	0	T	140994302	T	T	140994302	3	4	189	1	0	0	0	0	1	0	0	0	9233	913	32	2	1118	2	MAGEC1	23	140994302	Missense_Mutation	SNP	C	TCGA-CV-6433-01A-11D-1683-08	8167872	140994302	14276258	73	34903											
MEGF6	1953	broad.mit.edu	37	chr1	3428684	3428684	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccagccctgcggcacattCgtccacatctggaggggaga	8	6	14	13	2	1	1	0	0	1	1	3	3	2	2	3	5	2	1	3	5	0	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr1:3428684C>T	uc001akl.2	-	8	1089	c.862G>A	c.(862-864)GAA>AAA	p.E288K	MEGF6_uc001akk.2_Missense_Mutation_p.E183K	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	288	EGF-like 5; calcium-binding (Potential).					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCGGCACATTCGTCCACATCT	0.647													30	95					0	0	0	0	T	3428684	T	T	3428684	3	4	190	1	0	0	0	0	1	0	0	0	9515	893	31	1	3883	1	MEGF6	1	3428684	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08		3428684	245821937	1	34904											
TGFBR3	7049	broad.mit.edu	37	chr1	92161270	92161270	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaaggcccccgtcaggagtGctccgatcacaaaggctgca	11	5	11	14	2	2	0	2	0	0	0	3	2	3	1	3	3	2	3	3	3	2	0			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr1:92161270G>A	uc001doh.2	-	16	2862	c.2396C>T	c.(2395-2397)GCA>GTA	p.A799V	TGFBR3_uc009wde.2_Missense_Mutation_p.A494V|TGFBR3_uc010osy.1_Missense_Mutation_p.A757V|TGFBR3_uc001doi.2_Missense_Mutation_p.A798V|TGFBR3_uc001doj.2_Missense_Mutation_p.A798V	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	799	Helical; (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		CGTCAGGAGTGCTCCGATCAC	0.473													17	34					0	0	0	0	A	92161270	A	A	92161270	3	1	190	1	0	0	0	0	1	0	0	0	15889	1319	46	4	167	4	TGFBR3	1	92161270	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	88732586	92161270	157089351	2	34905											
HRNR	388697	broad.mit.edu	37	chr1	152187759	152187759	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgactgtaactagaggactGccctgagctagactcgtggt	9	10	12	10	1	0	4	0	2	0	2	1	5	0	5	1	2	3	2	1	2	3	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr1:152187759G>A	uc001ezt.1	-	3	6422	c.6346C>T	c.(6346-6348)CAG>TAG	p.Q2116*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2116	23.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTAGAGGACTGCCCTGAGCTA	0.582													11	494					0	0	0	0	A	152187759	A	A	152187759	4	1	190	1	0	0	0	0	0	1	0	0	7398	1328	46	4	2210	4	HRNR	1	152187759	Nonsense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	60026489	152187759	97062862	3	34906											
FLG	2312	broad.mit.edu	37	chr1	152281685	152281685	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcgagtgtctagagctgtCggcccgagaggaagcttcat	8	9	14	10	3	2	2	1	0	1	2	3	5	2	3	1	2	3	2	1	2	2	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr1:152281685C>T	uc001ezu.1	-	3	5713	c.5677G>A	c.(5677-5679)GAC>AAC	p.D1893N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1893	Ser-rich.|Filaggrin 11.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTAGAGCTGTCGGCCCGAGAG	0.572									Ichthyosis				56	235					0	0	0	0	T	152281685	T	T	152281685	3	4	190	1	0	0	0	0	1	0	0	0	5954	884	31	1	6512	1	FLG	1	152281685	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	93926	152281685	96968936	4	34907											
PLEKHA6	22874	broad.mit.edu	37	chr1	204210594	204210594	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtgggcgattttgtccgaGggggcacaacgccaactgca	9	7	14	11	3	0	0	0	0	0	0	1	2	1	0	2	3	3	2	2	3	2	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr1:204210594G>C	uc001hau.2	-	17	2635	c.2318C>G	c.(2317-2319)CCT>CGT	p.P773R	PLEKHA6_uc009xau.1_RNA	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	773										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TTTTGTCCGAGGGGGCACAAC	0.572													3	15					0	0	0	0	C	204210594	C	C	204210594	3	2	190	1	0	0	0	0	1	0	0	0	12115	1000	35	4	852	4	PLEKHA6	1	204210594	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	51928909	204210594	45040027	5	34908											
NTSR2	23620	broad.mit.edu	37	chr2	11802096	11802096	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttacagaggacttaactgaGaacctggacgctgcgctgga	11	8	13	9	2	0	2	0	1	0	2	0	6	0	5	1	3	4	3	1	3	3	2	rs145680805		TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr2:11802096G>A	uc002rbq.3	-	2	969	c.895C>T	c.(895-897)CTC>TTC	p.L299F		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	299	Helical; Name=6; (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	ACTTAACTGAGAACCTGGACG	0.383													20	89					0	0	0	0	A	11802096	A	A	11802096	3	1	190	1	0	0	0	0	1	0	0	0	10765	942	33	2	349	2	NTSR2	2	11802096	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08		11802096	231397277	6	34909											
CASP8	841	broad.mit.edu	37	chr2	202131241	202131241	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagaaatctttatgatattgGggaacaactggacagtgaag	15	10	11	5	0	1	3	0	2	1	1	1	5	1	5	0	3	2	0	0	3	6	4			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr2:202131241G>A	uc002uxr.1	+	3	241	c.32G>A	c.(31-33)GGG>GAG	p.G11E	CASP8_uc010ftc.1_Missense_Mutation_p.G11E|CASP8_uc002uxo.1_Missense_Mutation_p.G11E|CASP8_uc002uxp.1_Missense_Mutation_p.G11E|CASP8_uc002uxq.1_Missense_Mutation_p.G11E|CASP8_uc002uxs.1_Missense_Mutation_p.G11E|CASP8_uc002uxt.1_Missense_Mutation_p.G70E|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.G11E|CASP8_uc002uxw.1_Missense_Mutation_p.G11E|CASP8_uc002uxy.1_Missense_Mutation_p.G11E|CASP8_uc002uxx.1_Missense_Mutation_p.G11E|CASP8_uc010ftf.2_Missense_Mutation_p.G11E	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	11	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding	p.G11R(1)		upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TATGATATTGGGGAACAACTG	0.398										HNSCC(4;0.00038)			15	51					0	0	0	0	A	202131241	A	A	202131241	3	1	190	1	0	0	0	0	1	0	0	0	2689	1232	43	4	215	4	CASP8	2	202131241	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	190329145	202131241	41068132	7	34910											
LMCD1	29995	broad.mit.edu	37	chr3	8609125	8609125	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcctgctcccctccccaGataatattcgctgaggacta	8	12	6	15	1	1	2	0	1	1	1	5	3	3	3	5	1	1	2	5	1	3	5			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr3:8609125G>A	uc003bqq.2	+	6	1054	c.940_splice	c.e6-1	p.I314_splice	LMCD1_uc011atd.1_Splice_Site_p.I241_splice|LMCD1_uc011ate.1_Splice_Site_p.I202_splice	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1						positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		CCCCTCCCCAGATAATATTCG	0.532													44	230					0	0	0	0	A	8609125	A	A	8609125	5	1	190	1	0	0	0	0	0	0	1	0	8886	956	33	2	961	2	LMCD1	3	8609125	Splice_Site	SNP	G	TCGA-CV-6436-01A-11D-1683-08		8609125	189413305	8	34911			1	51		2	2	35	G		9.664636e-05
LMCD1	29995	broad.mit.edu	37	chr3	8609159	8609159	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggactaccagcgtgtggaaGatctggcctggcaccgaaag	11	6	14	10	2	1	1	0	0	1	1	1	4	1	3	3	4	2	1	3	4	3	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr3:8609159G>A	uc003bqq.2	+	6	1087	c.973G>A	c.(973-975)GAT>AAT	p.D325N	LMCD1_uc011atd.1_Missense_Mutation_p.D252N|LMCD1_uc011ate.1_Missense_Mutation_p.D213N	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	325	LIM zinc-binding 2.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		GCGTGTGGAAGATCTGGCCTG	0.552													51	248					0	0	0	0	A	8609159	A	A	8609159	3	1	190	1	0	0	0	0	1	0	0	0	8886	942	33	2	995	2	LMCD1	3	8609159	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	34	8609159	189413271	9	34912			1	51		2	2	35	G		9.664636e-05
CCDC13	152206	broad.mit.edu	37	chr3	42799629	42799629	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcatttacctcttctcaaagCtatttttcgagtttggctcc	7	17	6	11	1	2	0	1	0	2	0	5	1	3	0	2	1	2	4	2	1	3	7			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr3:42799629C>A	uc003cly.3	-	2	293	c.209G>T	c.(208-210)AGC>ATC	p.S70I	CCDC13_uc003clz.2_Missense_Mutation_p.S70I|CCDC13_uc011azq.1_Missense_Mutation_p.S70I	NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	70	Potential.									ovary(1)	1						CTTCTCAAAGCTATTTTTCGA	0.393													8	41					5.4927e-09	6.41671e-09	1	0	A	42799629	A	A	42799629	3	1	190	1	0	0	0	0	1	0	0	0	2777	797	28	4	1998	4	CCDC13	3	42799629	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	34190470	42799629	155222801	10	34913											
CCDC14	64770	broad.mit.edu	37	chr3	123665761	123665761	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacatccttcactgtttttgTatctcgcacatgtatgttta	8	19	5	9	1	2	0	1	0	1	0	4	0	3	0	1	0	1	5	1	0	4	8			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr3:123665761T>C	uc011bjx.1	-	8	1325	c.1234A>G	c.(1234-1236)ACA>GCA	p.T412A	CCDC14_uc003egv.3_Intron|CCDC14_uc003egx.3_Missense_Mutation_p.T212A|CCDC14_uc010hrt.2_Missense_Mutation_p.T371A|CCDC14_uc003egy.3_Missense_Mutation_p.T212A|CCDC14_uc003egz.2_Missense_Mutation_p.T212A	NM_022757	NP_073594	Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	412	Potential.					centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		ACTGTTTTTGTATCTCGCACA	0.383													31	104					0	0	0	0	C	123665761	C	C	123665761	3	2	190	1	0	0	0	0	1	0	0	0	2785	1638	57	5	1651	5	CCDC14	3	123665761	Missense_Mutation	SNP	T	TCGA-CV-6436-01A-11D-1683-08	80866132	123665761	74356669	11	34914											
PIK3CA	5290	broad.mit.edu	37	chr3	178916944	178916944	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagtaggcaaccgtgaagaaAagatcctcaatcgagaaatt	17	7	9	8	2	1	4	1	1	0	3	3	5	2	4	2	1	1	2	2	1	7	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr3:178916944A>G	uc003fjk.2	+	2	488	c.331A>G	c.(331-333)AAG>GAG	p.K111E		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	111					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.K111N(10)|p.K111E(7)|p.K111R(1)|p.K111del(1)|p.K111_I112>N(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCGTGAAGAAAAGATCCTCAA	0.333		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			23	64					0	0	0	0	G	178916944	G	G	178916944	3	3	190	1	0	0	0	0	1	0	0	0	11968	15	1	5	333	5	PIK3CA	3	178916944	Missense_Mutation	SNP	A	TCGA-CV-6436-01A-11D-1683-08	55251183	178916944	19105486	12	34915											
EIF4G1	1981	broad.mit.edu	37	chr3	184039612	184039612	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccccctcgccaccagctgtgGacttaagcccagtcagtgag	8	7	10	16	1	1	1	1	1	0	0	2	2	1	2	5	1	2	1	5	1	1	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr3:184039612G>A	uc003fnp.2	+	10	1438	c.1240G>A	c.(1240-1242)GAC>AAC	p.D414N	EIF4G1_uc003fno.1_Missense_Mutation_p.D355N|EIF4G1_uc010hxw.1_Missense_Mutation_p.D250N|EIF4G1_uc003fnt.2_Missense_Mutation_p.D125N|EIF4G1_uc003fnq.2_Missense_Mutation_p.D327N|EIF4G1_uc003fnr.2_Missense_Mutation_p.D250N|EIF4G1_uc010hxx.2_Missense_Mutation_p.D421N|EIF4G1_uc003fns.2_Missense_Mutation_p.D374N|EIF4G1_uc010hxy.2_Missense_Mutation_p.D421N|EIF4G1_uc003fnv.3_Missense_Mutation_p.D414N|EIF4G1_uc003fnu.3_Missense_Mutation_p.D414N|EIF4G1_uc003fnw.2_Missense_Mutation_p.D421N|EIF4G1_uc003fnx.2_Missense_Mutation_p.D218N|EIF4G1_uc003fny.3_Missense_Mutation_p.D218N	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	414					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity	p.D414N(1)		lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ACCAGCTGTGGACTTAAGCCC	0.632													64	255					0	0	0	0	A	184039612	A	A	184039612	3	1	190	1	0	0	0	0	1	0	0	0	5060	1174	41	2	1270	2	EIF4G1	3	184039612	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	5122668	184039612	13982818	13	34916											
JAKMIP1	152789	broad.mit.edu	37	chr4	6107523	6107523	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccttgatcttggcggtgcGcgccgcctcctgctcgtgct	1	12	12	16	5	1	1	0	1	1	0	4	1	3	1	4	2	3	2	4	2	0	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr4:6107523G>A	uc003giu.3	-	3	577	c.301C>T	c.(301-303)CGC>TGC	p.R101C	JAKMIP1_uc010idb.1_Missense_Mutation_p.R101C|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Missense_Mutation_p.R101C|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Missense_Mutation_p.R101C|JAKMIP1_uc010ide.2_Missense_Mutation_p.R101C	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	101	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TTGGCGGTGCGCGCCGCCTCC	0.677													4	17					0	0	0	0	A	6107523	A	A	6107523	3	1	190	1	0	0	0	0	1	0	0	0	7979	1087	38	1	2345	1	JAKMIP1	4	6107523	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08		6107523	185046753	14	34917											
AFF1	4299	broad.mit.edu	37	chr4	88035995	88035995	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgaacccaagccagcagtGcccccctccagtgagaagaa	14	3	9	15	1	0	2	0	1	0	2	1	4	1	2	6	0	5	1	6	0	5	0			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr4:88035995G>A	uc003hqj.3	+	11	2396	c.1989G>A	c.(1987-1989)GTG>GTA	p.V663V	AFF1_uc011ccz.1_Silent_p.V670V|AFF1_uc003hqk.3_Silent_p.V663V|AFF1_uc011cda.1_Silent_p.V301V	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	663						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		AGCCAGCAGTGCCCCCCTCCA	0.607													8	34					0	0	0	0	A	88035995	A	A	88035995	2	1	190	1	0	0	0	0	0	0	0	1	356	1306	46	4		4	AFF1	4	88035995	Silent	SNP	G	TCGA-CV-6436-01A-11D-1683-08	81928472	88035995	103118281	15	34918											
HSD17B11	51170	broad.mit.edu	37	chr4	88312141	88312141	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gactgattttctcctcttagGaataaaaagcttcacgaagg	13	12	8	8	1	3	1	1	1	2	0	4	4	3	2	1	2	1	1	1	2	6	5			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr4:88312141G>T	uc003hqp.2	-	1	315	c.82C>A	c.(82-84)CCT>ACT	p.P28T		NM_016245	NP_057329	Q8NBQ5	DHB11_HUMAN	estradiol 17-beta-dehydrogenase 11	28					androgen catabolic process|steroid biosynthetic process	cytoplasm|extracellular region	binding|estradiol 17-beta-dehydrogenase activity			ovary(2)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000339)		CTCCTCTTAGGAATAAAAAGC	0.468													14	39					4.3838e-07	4.89263e-07	1	0	T	88312141	T	T	88312141	3	4	190	1	0	0	0	0	1	0	0	0	7419	1174	41	2	848	2	HSD17B11	4	88312141	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	276146	88312141	102842135	16	34919											
FBXW7	55294	broad.mit.edu	37	chr4	153247289	153247289	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccatcatattgaacacagcGgactgctgcaacatgaccca	13	7	8	13	1	1	2	1	2	0	0	1	3	1	3	2	1	5	2	2	1	3	2	rs149680468		TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr4:153247289G>C	uc003ims.2	-	10	1662	c.1513C>G	c.(1513-1515)CGC>GGC	p.R505G	FBXW7_uc011cii.1_Missense_Mutation_p.R505G|FBXW7_uc003imt.2_Missense_Mutation_p.R505G|FBXW7_uc011cih.1_Missense_Mutation_p.R329G|FBXW7_uc003imq.2_Missense_Mutation_p.R425G|FBXW7_uc003imr.2_Missense_Mutation_p.R387G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468			Mis|N|D|F		colorectal|endometrial|T-ALL								27	87					0	0	0	0	C	153247289	C	C	153247289	3	2	190	1	0	0	0	0	1	0	0	0	5801	1116	39	3	622	3	FBXW7	4	153247289	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	64935148	153247289	37906987	17	34920											
GFRA3	2676	broad.mit.edu	37	chr5	137593489	137593489	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggccctgcgcgtggggctcGgcggccttctcgaagaaagt	6	7	16	12	5	1	1	0	0	1	1	3	2	1	1	2	5	1	1	2	5	2	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr5:137593489G>A	uc003lcn.2	-	4	764	c.624C>T	c.(622-624)GCC>GCT	p.A208A	GFRA3_uc003lco.2_Silent_p.A177A	NM_001496	NP_001487	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3 preproprotein	208					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CGTGGGGCTCGGCGGCCTTCT	0.726													11	33					0	0	0	0	A	137593489	A	A	137593489	2	1	190	1	0	0	0	0	0	0	0	1	6386	1103	39	1		1	GFRA3	5	137593489	Silent	SNP	G	TCGA-CV-6436-01A-11D-1683-08		137593489	43321771	18	34921											
KDM3B	51780	broad.mit.edu	37	chr5	137762666	137762666	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtattctctgtcttccagaaCgactacggtcagaagatggg	10	11	11	9	2	3	3	1	0	2	3	5	4	4	3	1	2	2	1	1	2	4	4			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr5:137762666C>T	uc003lcy.1	+	18	4614	c.4414C>T	c.(4414-4416)CGA>TGA	p.R1472*	KDM3B_uc010jew.1_Nonsense_Mutation_p.R1128*|KDM3B_uc011cys.1_Nonsense_Mutation_p.R504*	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1472					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						TCTTCCAGAACGACTACGGTC	0.458													8	28					0	0	0	0	T	137762666	T	T	137762666	4	4	190	1	0	0	0	0	0	1	0	0	8166	528	19	1	4484	1	KDM3B	5	137762666	Nonsense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	169177	137762666	43152594	19	34922											
PCDHA8	56140	broad.mit.edu	37	chr5	140220964	140220964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gactactactcttgcttctgCtcctcgcagcctggaaggtg	6	12	10	13	1	2	0	0	0	2	0	4	2	3	1	2	2	5	3	2	2	3	4			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr5:140220964C>T	uc003lhs.2	+	1	58	c.58C>T	c.(58-60)CTC>TTC	p.L20F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.L20F	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	20					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding	p.L20F(1)		upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTGCTTCTGCTCCTCGCAGC	0.547													13	85					0	0	0	0	T	140220964	T	T	140220964	3	4	190	1	0	0	0	0	1	0	0	0	11584	797	28	4	60	4	PCDHA8	5	140220964	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	2458298	140220964	40694296	20	34923											
PCDHB7	56129	broad.mit.edu	37	chr5	140553798	140553798	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctacaccctgtttgtccGtgagaacaacagccccgccc	8	8	7	18	2	0	1	0	1	0	1	2	2	2	1	6	0	4	1	6	0	3	2	rs137953621		TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr5:140553798G>A	uc003lit.2	+	1	1556	c.1382G>A	c.(1381-1383)CGT>CAT	p.R461H		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	461	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGTTTGTCCGTGAGAACAAC	0.607													18	85					0	0	0	0	A	140553798	A	A	140553798	3	1	190	1	0	0	0	0	1	0	0	0	11601	1145	40	1	1384	1	PCDHB7	5	140553798	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	332834	140553798	40361462	21	34924											
GCM2	9247	broad.mit.edu	37	chr6	10877388	10877388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcactctgctgtttcagccGtgccttgtcgcagatggccg	4	12	11	14	3	3	1	2	0	1	1	4	1	3	1	3	1	3	3	3	1	0	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr6:10877388G>A	uc003mzn.3	-	2	400	c.328C>T	c.(328-330)CGG>TGG	p.R110W	SYCP2L_uc011dim.1_Intron	NM_004752	NP_004743	O75603	GCM2_HUMAN	glial cells missing homolog 2	110	GCM.		R -> W (in FIH; abolishes DNA binding ability).		cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				TGTTTCAGCCGTGCCTTGTCG	0.507													15	81					0	0	0	0	A	10877388	A	A	10877388	3	1	190	1	0	0	0	0	1	0	0	0	6333	1144	40	1	1208	1	GCM2	6	10877388	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08		10877388	160237679	22	34925											
HIST1H2BD	3017	broad.mit.edu	37	chr6	26158692	26158692	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagggagatccagacggccGtgcgcctgctgcttccgggg	5	6	16	14	4	0	2	0	0	0	2	2	3	2	2	5	4	3	2	5	4	0	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr6:26158692G>C	uc003ngr.2	+	1	344	c.295G>C	c.(295-297)GTG>CTG	p.V99L	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.V99L	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	99					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						CCAGACGGCCGTGCGCCTGCT	0.617													20	94					0	0	0	0	C	26158692	C	C	26158692	3	2	190	1	0	0	0	0	1	0	0	0	7182	1145	40	3	297	3	HIST1H2BD	6	26158692	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	15281304	26158692	144956375	23	34926											
HIST1H2BJ	8970	broad.mit.edu	37	chr6	27100520	27100520	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggcgggagcagacttcgctgGctctggcatagcactgtgta	7	9	15	10	2	1	1	0	0	1	1	2	2	1	2	0	4	2	6	0	4	2	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr6:27100520G>T	uc003niv.2	-	1	56	c.10C>A	c.(10-12)CCA>ACA	p.P4T	HIST1H2BJ_uc003niu.1_RNA|HIST1H2AG_uc003niw.2_5'Flank	NM_021058	NP_066402	P06899	H2B1J_HUMAN	histone cluster 1, H2bj	4					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						GACTTCGCTGGCTCTGGCATA	0.527													10	63					2.17888e-05	2.38912e-05	1	0	T	27100520	T	T	27100520	3	4	190	1	0	0	0	0	1	0	0	0	7188	1203	42	4	374	4	HIST1H2BJ	6	27100520	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	941828	27100520	144014547	24	34927											
PKHD1	5314	broad.mit.edu	37	chr6	51907774	51907774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcaccaacatcaagatccGatgcattccaacaggtagca	14	8	6	13	1	2	1	2	0	1	1	5	2	4	1	3	1	4	3	3	1	4	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr6:51907774G>A	uc003pah.1	-	27	3256	c.2980C>T	c.(2980-2982)CGG>TGG	p.R994W	PKHD1_uc003pai.2_Missense_Mutation_p.R994W	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	994	IPT/TIG 4.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.R994W(1)		lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					ATCAAGATCCGATGCATTCCA	0.453													17	63					0	0	0	0	A	51907774	A	A	51907774	3	1	190	1	0	0	0	0	1	0	0	0	12026	1057	37	1	9447	1	PKHD1	6	51907774	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	24807254	51907774	119207293	25	34928											
COX7A2	1347	broad.mit.edu	37	chr6	75950913	75950913	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaacagtttttgcttctcCggaactttatttttaaaatg	10	18	7	6	1	1	0	0	0	1	0	2	2	1	2	1	2	3	2	1	2	5	8			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr6:75950913C>T	uc003phv.1	-	2	162	c.87G>A	c.(85-87)CCG>CCA	p.P29P		NM_001865	NP_001856	P14406	CX7A2_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 2	29						mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0						TTTGCTTCTCCGGAACTTTAT	0.343													30	143					0	0	0	0	T	75950913	T	T	75950913	2	4	190	1	0	0	0	0	0	0	0	1	3795	639	23	1		1	COX7A2	6	75950913	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08	24043139	75950913	95164154	26	34929											
EPHA7	2045	broad.mit.edu	37	chr6	93967961	93967961	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgcaacatctcttttccCtggaagtttcaaacggccac	10	12	6	13	1	2	0	1	0	1	0	4	1	3	1	2	2	4	2	2	2	4	4			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr6:93967961C>A	uc003poe.2	-	11	2207	c.1966G>T	c.(1966-1968)GGG>TGG	p.G656W	EPHA7_uc003pof.2_Missense_Mutation_p.G651W|EPHA7_uc011eac.1_Missense_Mutation_p.G652W	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	656	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity	p.G656W(1)		lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TCTCTTTTCCCTGGAAGTTTC	0.383													20	79					3.83957e-06	4.24731e-06	1	0	A	93967961	A	A	93967961	3	1	190	1	0	0	0	0	1	0	0	0	5196	681	24	4	1058	4	EPHA7	6	93967961	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	18017048	93967961	77147106	27	34930											
UTRN	7402	broad.mit.edu	37	chr6	145021235	145021235	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaacagggcccatttggaGgccagcgctgagaagtggaa	11	6	14	10	1	1	1	1	1	0	1	1	4	1	3	2	4	2	1	2	4	3	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr6:145021235G>A	uc003qkt.2	+	52	7757	c.7665G>A	c.(7663-7665)GAG>GAA	p.E2555E		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2555	Spectrin 17.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CCCATTTGGAGGCCAGCGCTG	0.353													9	47					0	0	0	0	A	145021235	A	A	145021235	2	1	190	1	0	0	0	0	0	0	0	1	17171	991	35	4		4	UTRN	6	145021235	Silent	SNP	G	TCGA-CV-6436-01A-11D-1683-08	51053274	145021235	26093832	28	34931											
C7orf63	79846	broad.mit.edu	37	chr7	89915651	89915651	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggaagaagccattgttttgGaaatccagtctgatatatta	14	13	9	5	0	1	2	0	1	1	1	2	4	2	4	2	2	1	1	2	2	6	6			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr7:89915651G>T	uc010lep.2	+	14	1845	c.1594G>T	c.(1594-1596)GAA>TAA	p.E532*	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_Nonsense_Mutation_p.E207*|C7orf63_uc011khj.1_Nonsense_Mutation_p.E514*|C7orf63_uc011khk.1_Nonsense_Mutation_p.E94*	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	532							binding			ovary(1)	1						CATTGTTTTGGAAATCCAGTC	0.348													13	63					4.3838e-07	4.89263e-07	1	0	T	89915651	T	T	89915651	4	4	190	1	0	0	0	0	0	1	0	0	2420	1175	41	2	1648	2	C7orf63	7	89915651	Nonsense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08		89915651	69223012	29	34932											
SRPK2	6733	broad.mit.edu	37	chr7	104801043	104801043	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatggtggccaagtacttCgaagaccatgcagacatctg	12	8	12	9	1	1	3	0	0	1	3	2	5	1	3	2	2	2	2	2	2	3	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr7:104801043C>A	uc003vct.2	-	6	686	c.499G>T	c.(499-501)GAA>TAA	p.E167*	SRPK2_uc003vcu.2_Nonsense_Mutation_p.E167*|SRPK2_uc003vcv.2_Nonsense_Mutation_p.E178*|SRPK2_uc003vcw.1_Nonsense_Mutation_p.E167*	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	167	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.E167*(1)		central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CCAAGTACTTCGAAGACCATG	0.473													9	26					1.76689e-08	2.04502e-08	1	0	A	104801043	A	A	104801043	4	1	190	1	0	0	0	0	0	1	0	0	15226	893	31	3	1607	3	SRPK2	7	104801043	Nonsense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	14885392	104801043	54337620	30	34933											
ZNF467	168544	broad.mit.edu	37	chr7	149461821	149461821	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcagaagaagagcgggggCggcgccacctcggggggagc	8	2	20	11	4	1	3	1	0	0	3	2	4	1	4	2	6	2	1	2	6	2	0			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr7:149461821C>T	uc003wgd.2	-	5	1911	c.1770G>A	c.(1768-1770)CCG>CCA	p.P590P	ZNF467_uc003wgc.2_Intron	NM_207336	NP_997219	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	590					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGAGCGGGGGCGGCGCCACCT	0.701													4	14					0	0	0	0	T	149461821	T	T	149461821	2	4	190	1	0	0	0	0	0	0	0	1	17994	755	27	1		1	ZNF467	7	149461821	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08	44660778	149461821	9676842	31	34934											
GPR20	2843	broad.mit.edu	37	chr8	142367698	142367698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgccgtagtacacagcgaagCgcgtgggcagggacagccct	9	4	15	13	5	0	0	0	0	0	0	0	2	0	1	2	2	4	3	2	2	3	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr8:142367698C>T	uc003ywf.2	-	2	415	c.326G>A	c.(325-327)CGC>CAC	p.R109H		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	109	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity	p.R109H(1)		upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CACAGCGAAGCGCGTGGGCAG	0.617													16	48					0	0	0	0	T	142367698	T	T	142367698	3	4	190	1	0	0	0	0	1	0	0	0	6718	768	27	1	754	1	GPR20	8	142367698	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08		142367698	3996324	32	34935											
CDKN2A	1029	broad.mit.edu	37	chr9	21971000	21971000	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacatcgcgatggcccagctCctcagccaggtccacgggca	8	5	12	16	3	1	0	1	0	0	0	4	2	3	0	4	3	2	2	4	3	0	0			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr9:21971000C>A	uc003zpk.2	-	2	570	c.358G>T	c.(358-360)GAG>TAG	p.E120*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	120	ANK 4.		E -> A (in non-small cell lung carcinoma).|E -> K (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E120*(8)|p.E120K(4)|p.E120A(1)|p.A118fs*10(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGGCCCAGCTCCTCAGCCAGG	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	21					0.00829132	0.00885825	1	0	A	21971000	A	A	21971000	4	1	190	1	0	0	0	0	0	1	0	0	3176	864	30	2	120	2	CDKN2A	9	21971000	Nonsense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08		21971000	119242431	33	34936											
VPS13A	23230	broad.mit.edu	37	chr9	79930243	79930244	+	Frame_Shift_Ins	INS	-	T	T																															aggaaagtcagagatggttgINStgtgactgatgcggtctttc																										TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr9:79930243_79930244insT	uc004akr.2	+	38	4747_4748	c.4487_4488insT	c.(4486-4488)TGTfs	p.C1496fs	VPS13A_uc004akp.3_Frame_Shift_Ins_p.C1496fs|VPS13A_uc004akq.3_Frame_Shift_Ins_p.C1496fs|VPS13A_uc004aks.2_Frame_Shift_Ins_p.C1457fs|VPS13A_uc004akt.2_5'Flank|VPS13A_uc010mpo.1_Frame_Shift_Ins_p.C92fs	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1496					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						AGAGATGGTTGTGTGACTGATG	0.396													---	---	---								T	79930244	T	T	79930243	7	5	190	1	0	1	1	0	0	0	0	0	17257	1377	48	0	4637	0	VPS13A	9	79930243	Frame_Shift_Ins	INS	-	TCGA-CV-6436-01A-11D-1683-08	57959243	79930243	61283188	34	34937											
SLC28A3	64078	broad.mit.edu	37	chr9	86905135	86905135	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacccggcggtcatgatggcGtggagttcagacttggtgat	8	10	15	8	3	2	3	2	2	0	1	2	4	2	4	1	5	1	1	1	5	1	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr9:86905135G>A	uc010mpz.2	-	11	1208	c.1083C>T	c.(1081-1083)CAC>CAT	p.H361H	SLC28A3_uc011lsy.1_Silent_p.H292H|SLC28A3_uc004anu.1_Silent_p.H361H	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	361	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TCATGATGGCGTGGAGTTCAG	0.463													12	50					0	0	0	0	A	86905135	A	A	86905135	2	1	190	1	0	0	0	0	0	0	0	1	14597	1136	40	1		1	SLC28A3	9	86905135	Silent	SNP	G	TCGA-CV-6436-01A-11D-1683-08	6974892	86905135	54308296	35	34938											
COL27A1	85301	broad.mit.edu	37	chr9	116930231	116930231	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcctgcagttcctcccCggcaagacggtcgtccacct	5	8	11	17	3	0	1	0	0	0	1	4	1	3	1	6	3	1	3	6	3	1	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr9:116930231C>T	uc011lxl.1	+	3	396	c.396C>T	c.(394-396)CCC>CCT	p.P132P	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_5'UTR	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	132	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						AGTTCCTCCCCGGCAAGACGG	0.682													26	69					0	0	0	0	T	116930231	T	T	116930231	2	4	190	1	0	0	0	0	0	0	0	1	3700	639	23	1		1	COL27A1	9	116930231	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08	30025096	116930231	24283200	36	34939											
TTF1	7270	broad.mit.edu	37	chr9	135277682	135277682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccgctggctctcccaggatGcagctttcctctgatgcttt	4	13	9	15	1	2	1	0	1	2	0	4	2	3	2	3	2	3	5	3	2	0	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr9:135277682G>A	uc004cbl.2	-	2	579	c.527C>T	c.(526-528)GCA>GTA	p.A176V	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	176	N-terminal region (NRD) (By similarity).				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding	p.A176V(1)		ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CTCCCAGGATGCAGCTTTCCT	0.493													16	31					0	0	0	0	A	135277682	A	A	135277682	3	1	190	1	0	0	0	0	1	0	0	0	16786	1319	46	4	2230	4	TTF1	9	135277682	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	18347451	135277682	5935749	37	34940											
RXRA	6256	broad.mit.edu	37	chr9	137328348	137328348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctccgcctgccggctctgcGctccatcgggctcaaatgcc	4	8	11	18	4	2	0	1	0	1	0	5	0	4	0	5	2	3	4	5	2	1	0			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr9:137328348G>A	uc004cfb.2	+	10	1439	c.1277G>A	c.(1276-1278)CGC>CAC	p.R426H	RXRA_uc004cfc.1_Missense_Mutation_p.R329H	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	426	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding	p.R426H(1)		upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CCGGCTCTGCGCTCCATCGGG	0.612													27	71					0	0	0	0	A	137328348	A	A	137328348	3	1	190	1	0	0	0	0	1	0	0	0	13828	1087	38	1	1315	1	RXRA	9	137328348	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	2050666	137328348	3885083	38	34941											
MPP7	143098	broad.mit.edu	37	chr10	28413008	28413008	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttatcctccactggtatcccGttgacttccctaagttcatc	7	15	5	14	1	1	1	1	1	0	0	6	1	5	1	4	1	0	3	4	1	3	6			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr10:28413008G>A	uc001iua.1	-	10	971	c.567C>T	c.(565-567)AAC>AAT	p.N189N	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Silent_p.N189N|MPP7_uc009xla.2_Silent_p.N189N|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	189	PDZ.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						CTGGTATCCCGTTGACTTCCC	0.358													8	78					0	0	0	0	A	28413008	A	A	28413008	2	1	190	1	0	0	0	0	0	0	0	1	9792	1136	40	1		1	MPP7	10	28413008	Silent	SNP	G	TCGA-CV-6436-01A-11D-1683-08		28413008	107121739	39	34942											
WDR11	55717	broad.mit.edu	37	chr10	122622272	122622272	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagcgagggtattgttttCatctcagacttctccccatc	8	13	7	13	1	3	1	2	0	2	1	6	2	3	1	3	1	1	2	3	1	1	5			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr10:122622272C>T	uc010qtf.1	+	5	790	c.552C>T	c.(550-552)TTC>TTT	p.F184F	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	184						integral to membrane					0						GTATTGTTTTCATCTCAGACT	0.418													39	133					0	0	0	0	T	122622272	T	T	122622272	2	4	190	1	0	0	0	0	0	0	0	1	17341	825	29	2		2	WDR11	10	122622272	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08	94209264	122622272	12912475	40	34943											
HRAS	3265	broad.mit.edu	37	chr11	534288	534288	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgcactcttgcccacaccgCcggcgcccaccaccaccagc	7	3	8	23	4	1	0	0	0	1	0	1	0	1	0	7	1	2	1	7	1	0	1	rs104894230		TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr11:534288C>T	uc001lpv.2	-	2	223	c.35G>A	c.(34-36)GGC>GAC	p.G12D	HRAS_uc010qvw.1_Missense_Mutation_p.G12D|HRAS_uc010qvx.1_Missense_Mutation_p.G12D|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	12	GTP.		G -> S (in FCSS, OSCC and CMEMS).|G -> E (in FCSS).|G -> C (in FCSS).|G -> A (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12V(250)|p.G12S(54)|p.G12D(40)|p.G12C(23)|p.G12R(12)|p.G12A(7)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GCCCACACCGCCGGCGCCCAC	0.647	G12V(T24_URINARY_TRACT)|G12D(HS578T_BREAST)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			15	20					0	0	0	0	T	534288	T	T	534288	3	4	190	1	0	0	0	0	1	0	0	0	7387	739	26	4	617	4	HRAS	11	534288	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08		534288	134472228	41	34944											
ST5	6764	broad.mit.edu	37	chr11	8772184	8772184	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacctgctcagagtcccccGaggggctttagtgccaccag	7	7	11	16	1	1	1	1	0	0	1	2	2	2	1	6	2	2	2	6	2	1	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr11:8772184G>A	uc001mgt.2	-	2	250	c.64C>T	c.(64-66)CGG>TGG	p.R22W	ST5_uc009yfr.2_Missense_Mutation_p.R22W|ST5_uc001mgu.2_Missense_Mutation_p.R22W|ST5_uc001mgv.2_Missense_Mutation_p.R22W|ST5_uc010rbq.1_RNA|ST5_uc001mgw.1_Missense_Mutation_p.R22W	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	22					positive regulation of ERK1 and ERK2 cascade		protein binding	p.R22W(1)		upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		AGAGTCCCCCGAGGGGCTTTA	0.552													117	191					0	0	0	0	A	8772184	A	A	8772184	3	1	190	1	0	0	0	0	1	0	0	0	15286	1057	37	1	3425	1	ST5	11	8772184	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	8237896	8772184	126234332	42	34945											
DKK3	27122	broad.mit.edu	37	chr11	11986065	11986065	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagccgcaggctccctcagCgccatctcttcagtcaggct	6	8	10	17	2	4	0	3	0	1	0	6	0	5	0	3	2	2	4	3	2	0	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr11:11986065C>T	uc001mju.2	-	7	1056	c.999G>A	c.(997-999)GCG>GCA	p.A333A	DKK3_uc010rcf.1_Silent_p.A305A|DKK3_uc001mjv.2_Silent_p.A333A|DKK3_uc001mjw.2_Silent_p.A333A|DKK3_uc010rcg.1_Silent_p.A347A	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	333					adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		GCTCCCTCAGCGCCATCTCTT	0.577													15	118					0	0	0	0	T	11986065	T	T	11986065	2	4	190	1	0	0	0	0	0	0	0	1	4568	755	27	1		1	DKK3	11	11986065	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08	3213881	11986065	123020451	43	34946											
AGBL2	79841	broad.mit.edu	37	chr11	47707594	47707594	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacagaacctctctttcttCaagaagtctattgagggggc	11	11	9	10	0	4	3	1	1	3	2	5	3	4	3	1	2	2	0	1	2	5	4			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr11:47707594C>T	uc001ngg.2	-	10	1739	c.1639G>A	c.(1639-1641)GAA>AAA	p.E547K	AGBL2_uc001ngf.2_Intron|AGBL2_uc010rhq.1_Missense_Mutation_p.E509K|AGBL2_uc001ngh.1_Missense_Mutation_p.E491K	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic	547					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						TCTCTTTCTTCAAGAAGTCTA	0.383													14	38					0	0	0	0	T	47707594	T	T	47707594	3	4	190	1	0	0	0	0	1	0	0	0	376	835	29	2	1105	2	AGBL2	11	47707594	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	35721529	47707594	87298922	44	34947											
NUP160	23279	broad.mit.edu	37	chr11	47833636	47833636	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcatctccaagcctcattaAcagctgctgtaagatcaaaa	15	9	6	11	0	3	1	2	0	1	1	4	1	3	1	2	0	5	4	2	0	5	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr11:47833636A>G	uc001ngm.2	-	17	2306	c.2221T>C	c.(2221-2223)TTA>CTA	p.L741L	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	741					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						AGCCTCATTAACAGCTGCTGT	0.408													5	42					0	0	0	0	G	47833636	G	G	47833636	2	3	190	1	0	0	0	0	0	0	0	1	10811	40	2	5		5	NUP160	11	47833636	Silent	SNP	A	TCGA-CV-6436-01A-11D-1683-08	126042	47833636	87172880	45	34948											
TRIM48	79097	broad.mit.edu	37	chr11	55032498	55032498	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttttgcaggccctgtttctAcctcaactggcaagacatcc	8	12	7	14	0	2	1	1	0	1	1	3	1	3	1	3	2	3	3	3	2	3	4			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr11:55032498A>G	uc010rid.1	+	2	253	c.167A>G	c.(166-168)TAC>TGC	p.Y56C		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	40	RING-type.					intracellular	zinc ion binding				0						CCCTGTTTCTACCTCAACTGG	0.458													23	96					0	0	0	0	G	55032498	G	G	55032498	3	3	190	1	0	0	0	0	1	0	0	0	16590	391	14	5	173	5	TRIM48	11	55032498	Missense_Mutation	SNP	A	TCGA-CV-6436-01A-11D-1683-08	7198862	55032498	79974018	46	34949											
OR4C15	81309	broad.mit.edu	37	chr11	55322467	55322467	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggccccaatgtcatcaatCactttatgtgtgacttgtac	9	14	8	10	0	3	1	3	1	0	0	3	1	3	1	2	1	1	1	2	1	4	4			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr11:55322467C>A	uc010rig.1	+	1	685	c.685C>A	c.(685-687)CAC>AAC	p.H229N		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGTCATCAATCACTTTATGTG	0.468										HNSCC(20;0.049)			11	33					3.86212e-05	4.19796e-05	1	0	A	55322467	A	A	55322467	3	1	190	1	0	0	0	0	1	0	0	0	11102	826	29	2	687	2	OR4C15	11	55322467	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	289969	55322467	79684049	47	34950											
SF1	7536	broad.mit.edu	37	chr11	64544069	64544069	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cattgtgtcttggttccagcGgctcctcttccgcttcttac	3	16	8	14	2	3	0	0	0	3	0	6	0	6	0	3	2	2	3	3	2	1	6			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr11:64544069G>A	uc001obb.1	-	2	438	c.61C>T	c.(61-63)CGC>TGC	p.R21C	SF1_uc010rnn.1_5'UTR|SF1_uc001oaz.1_Missense_Mutation_p.R146C|SF1_uc001oba.1_Missense_Mutation_p.R21C|SF1_uc001obc.1_Missense_Mutation_p.R21C|SF1_uc001obd.1_Missense_Mutation_p.R21C|SF1_uc001obe.1_5'UTR|SF1_uc010rno.1_5'UTR|SF1_uc001obf.2_Missense_Mutation_p.R21C	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	21				R->K: No effect.|R->A: Decreases interaction with U2AF2 and spliceosome assembly.	nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						TGGTTCCAGCGGCTCCTCTTC	0.428													8	68					0	0	0	0	A	64544069	A	A	64544069	3	1	190	1	0	0	0	0	1	0	0	0	14210	1116	39	1	2044	1	SF1	11	64544069	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	9221602	64544069	70462447	48	34951											
CNTN5	53942	broad.mit.edu	37	chr11	99690283	99690283	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttctcttacagagtattcaAaatctcttcctggtctctcc	8	17	4	12	0	4	1	1	0	3	1	9	1	6	1	2	1	1	1	2	1	4	5			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr11:99690283A>G	uc001pga.2	+	4	403	c.64A>G	c.(64-66)AAA>GAA	p.K22E	CNTN5_uc009ywv.1_Missense_Mutation_p.K22E|CNTN5_uc001pfz.2_Missense_Mutation_p.K22E|CNTN5_uc001pgb.2_Intron	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	22					cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGAGTATTCAAAATCTCTTCC	0.308													3	67					0	0	0	0	G	99690283	G	G	99690283	3	3	190	1	0	0	0	0	1	0	0	0	3659	15	1	5	70	5	CNTN5	11	99690283	Missense_Mutation	SNP	A	TCGA-CV-6436-01A-11D-1683-08	35146214	99690283	35316233	49	34952											
ETV6	2120	broad.mit.edu	37	chr12	12022544	12022544	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgcctctccccggctgagaGagctcagggacccaggccgc	6	4	13	18	3	2	2	1	1	1	1	3	4	2	3	6	3	1	2	6	3	0	0			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr12:12022544G>C	uc001qzz.2	+	5	924	c.650G>C	c.(649-651)AGA>ACA	p.R217T	ETV6_uc001raa.1_Missense_Mutation_p.R10T	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	217						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R217T(1)	ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CCGGCTGAGAGAGCTCAGGGA	0.632			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								18	95					0	0	0	0	C	12022544	C	C	12022544	3	2	190	1	0	0	0	0	1	0	0	0	5307	942	33	2	668	2	ETV6	12	12022544	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08		12022544	121829351	50	34953											
DENND5B	160518	broad.mit.edu	37	chr12	31613307	31613307	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctgccacagtcatcaggcGttgataatctgcacagaaca	12	10	8	11	1	4	2	2	1	2	1	4	2	4	2	1	1	3	2	1	1	2	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr12:31613307G>A	uc001rki.1	-	4	1099	c.913C>T	c.(913-915)CGC>TGC	p.R305C	DENND5B_uc001rkh.1_Missense_Mutation_p.R340C|DENND5B_uc009zjq.1_Missense_Mutation_p.R224C|DENND5B_uc001rkj.2_Missense_Mutation_p.R327C|DENND5B_uc001rkk.1_Missense_Mutation_p.R227C	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	305	DENN.					integral to membrane				ovary(1)|central_nervous_system(1)	2						GTCATCAGGCGTTGATAATCT	0.393													7	28					0	0	0	0	A	31613307	A	A	31613307	3	1	190	1	0	0	0	0	1	0	0	0	4459	1145	40	1	2983	1	DENND5B	12	31613307	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	19590763	31613307	102238588	51	34954											
IKBIP	121457	broad.mit.edu	37	chr12	99007411	99007411	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatctttaatatccttaatCtcagcttggactattgttaa	11	18	4	8	0	3	0	2	0	2	0	5	1	4	1	1	1	1	2	1	1	5	8	rs142399666	by1000genomes	TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr12:99007411C>T	uc001tfv.2	-	3	1115	c.1005G>A	c.(1003-1005)GAG>GAA	p.E335E	IKBIP_uc001tfw.2_3'UTR	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	335					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0						TATCCTTAATCTCAGCTTGGA	0.308													10	56					0	0	0	0	T	99007411	T	T	99007411	2	4	190	1	0	0	0	0	0	0	0	1	7648	912	32	2		2	IKBIP	12	99007411	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08	67394104	99007411	34844484	52	34955											
APPL2	55198	broad.mit.edu	37	chr12	105597508	105597508	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccatgtctgcaacggaggatAaaaagctgtccatacgtttg	12	10	10	9	2	1	0	0	0	1	0	2	2	2	2	2	2	4	3	2	2	5	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr12:105597508A>G	uc001tlf.1	-	9	895	c.677T>C	c.(676-678)TTA>TCA	p.L226S	APPL2_uc010swt.1_Missense_Mutation_p.L183S|APPL2_uc001tlg.1_5'UTR|APPL2_uc010swu.1_Missense_Mutation_p.L232S|APPL2_uc009zuq.2_Missense_Mutation_p.L183S	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	226	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding	p.L226S(1)		upper_aerodigestive_tract(1)	1						AACGGAGGATAAAAAGCTGTC	0.433													43	170					0	0	0	0	G	105597508	G	G	105597508	3	3	190	1	0	0	0	0	1	0	0	0	818	372	13	5	1369	5	APPL2	12	105597508	Missense_Mutation	SNP	A	TCGA-CV-6436-01A-11D-1683-08	6590097	105597508	28254387	53	34956											
ACAD10	80724	broad.mit.edu	37	chr12	112167625	112167625	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcaggggactatattccacGccaggtacgaacctgggtta	10	8	12	11	3	0	0	0	0	0	0	1	2	1	1	3	4	2	3	3	4	5	5			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr12:112167625G>T	uc001tsq.2	+	10	1459	c.1259G>T	c.(1258-1260)CGC>CTC	p.R420L	ACAD10_uc001tsp.2_Missense_Mutation_p.R420L|ACAD10_uc009zvx.2_Missense_Mutation_p.R451L|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	420							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						TATATTCCACGCCAGGTACGA	0.473													13	38					6.72482e-11	8.08272e-11	1	0	T	112167625	T	T	112167625	3	4	190	1	0	0	0	0	1	0	0	0	108	1087	38	3	1390	3	ACAD10	12	112167625	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	6570117	112167625	21684270	54	34957											
DDX54	79039	broad.mit.edu	37	chr12	113599136	113599136	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgccggtcagatgccccttcTtcgtccgagtcacgatcatc	6	10	9	16	5	4	1	3	0	1	1	7	3	5	1	4	1	1	0	4	1	0	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr12:113599136T>G	uc001tup.2	-	19	2380	c.2352A>C	c.(2350-2352)GAA>GAC	p.E784D	DDX54_uc001tuq.3_Missense_Mutation_p.E784D	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	784					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						ATGCCCCTTCTTCGTCCGAGT	0.577													10	51					0	0	0	0	G	113599136	G	G	113599136	3	3	190	1	0	0	0	0	1	0	0	0	4389	1606	56	5	304	5	DDX54	12	113599136	Missense_Mutation	SNP	T	TCGA-CV-6436-01A-11D-1683-08	1431511	113599136	20252759	55	34958											
KSR2	283455	broad.mit.edu	37	chr12	117914339	117914339	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtcgggggacagctggcGgatgatctctggtgccaggt	5	10	18	8	2	1	1	0	1	1	0	3	3	1	3	1	6	2	1	1	6	0	0			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr12:117914339G>A	uc001two.2	-	17	2480	c.2425C>T	c.(2425-2427)CGC>TGC	p.R809C		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	838	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GACAGCTGGCGGATGATCTCT	0.582													7	7					0	0	0	0	A	117914339	A	A	117914339	3	1	190	1	0	0	0	0	1	0	0	0	8622	1116	39	1	356	1	KSR2	12	117914339	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	4315203	117914339	15937556	56	34959											
TDRD3	81550	broad.mit.edu	37	chr13	61084005	61084005	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagaagcagcactgaacgtaCttcttacaagcaataaacag	17	8	7	9	1	1	2	0	1	1	1	1	2	1	2	0	0	7	4	0	0	9	5			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr13:61084005C>G	uc001via.2	+	9	1476	c.688C>G	c.(688-690)CTT>GTT	p.L230V	TDRD3_uc010aef.2_Missense_Mutation_p.L55V|TDRD3_uc001vhz.3_Missense_Mutation_p.L230V|TDRD3_uc010aeg.2_Missense_Mutation_p.L323V|TDRD3_uc001vib.3_Missense_Mutation_p.L229V	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	230	UBA.				chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity	p.L230V(1)		upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		ACTGAACGTACTTCTTACAAG	0.408													18	76					0	0	0	0	G	61084005	G	G	61084005	3	3	190	1	0	0	0	0	1	0	0	0	15798	565	20	4	1001	4	TDRD3	13	61084005	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08		61084005	54085873	57	34960											
ADAM21	8747	broad.mit.edu	37	chr14	70924430	70924430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcggtttgggggccagaaaCacgttgttcatatgagggtc	8	11	15	7	2	1	2	1	1	0	1	2	2	1	2	1	4	2	3	1	4	2	4			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr14:70924430C>T	uc001xmd.2	+	1	214	c.214C>T	c.(214-216)CAC>TAC	p.H72Y		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	72					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GGGCCAGAAACACGTTGTTCA	0.527													15	109					0	0	0	0	T	70924430	T	T	70924430	3	4	190	1	0	0	0	0	1	0	0	0	243	478	17	4	216	4	ADAM21	14	70924430	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08		70924430	36425110	58	34961											
LGMN	5641	broad.mit.edu	37	chr14	93172970	93172970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagcaaggagacgatcttaCgcactgacttctcaatgagg	12	8	10	11	2	2	3	1	2	2	1	3	5	2	3	1	2	2	2	1	2	3	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr14:93172970C>T	uc001yav.2	-	13	1375	c.1049G>A	c.(1048-1050)CGT>CAT	p.R350H	LGMN_uc001yat.2_Intron|LGMN_uc001yau.2_Intron|LGMN_uc001yaw.2_Missense_Mutation_p.R350H|LGMN_uc010aul.2_Missense_Mutation_p.R231H|LGMN_uc001yax.2_Intron|LGMN_uc001yay.2_Intron	NM_001008530	NP_001008530	Q99538	LGMN_HUMAN	legumain preproprotein	350					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			skin(1)	1		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		GACGATCTTACGCACTGACTT	0.637													13	32					0	0	0	0	T	93172970	T	T	93172970	3	4	190	1	0	0	0	0	1	0	0	0	8796	536	19	1	264	1	LGMN	14	93172970	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	22248540	93172970	14176570	59	34962											
PPP4R4	57718	broad.mit.edu	37	chr14	94674875	94674875	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgacagaatcccactgagaCgcttcggagagtgttgccaa	11	7	12	11	3	0	3	0	1	0	3	2	6	1	3	2	1	1	2	2	1	2	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr14:94674875C>T	uc001ycs.1	+	3	420	c.266C>T	c.(265-267)ACG>ATG	p.T89M	PPP4R4_uc001ycr.2_Missense_Mutation_p.T89M	NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	89						cytoplasm|protein serine/threonine phosphatase complex	protein binding	p.T89M(1)		skin(3)|upper_aerodigestive_tract(1)	4						CCCACTGAGACGCTTCGGAGA	0.388													4	10					0	0	0	0	T	94674875	T	T	94674875	3	4	190	1	0	0	0	0	1	0	0	0	12465	536	19	1	276	1	PPP4R4	14	94674875	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	1501905	94674875	12674665	60	34963											
ATP10A	57194	broad.mit.edu	37	chr15	25961901	25961901	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcgtggctgatccggggaCgtgacgacgactgtgttgca	6	10	16	9	5	0	2	0	2	0	0	2	5	1	3	1	3	1	4	1	3	0	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr15:25961901C>T	uc010ayu.2	-	9	1858	c.1752G>A	c.(1750-1752)ACG>ACA	p.T584T		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	584	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GATCCGGGGACGTGACGACGA	0.592													13	86					0	0	0	0	T	25961901	T	T	25961901	2	4	190	1	0	0	0	0	0	0	0	1	1118	523	19	1		1	ATP10A	15	25961901	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08		25961901	76569491	61	34964											
ISLR2	57611	broad.mit.edu	37	chr15	74425583	74425583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccggctgcgtacgctggCgcctggcaccttcgacgcgc	5	6	13	17	7	0	0	0	0	0	0	1	1	0	0	3	3	3	4	3	3	2	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr15:74425583C>T	uc002axd.2	+	4	1257	c.488C>T	c.(487-489)GCG>GTG	p.A163V	ISLR2_uc002axe.2_Missense_Mutation_p.A163V|ISLR2_uc010bjg.2_Missense_Mutation_p.A163V|ISLR2_uc010bjf.2_Missense_Mutation_p.A163V	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	163	Extracellular (Potential).|LRR 5.				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						CGTACGCTGGCGCCTGGCACC	0.652													22	95					0	0	0	0	T	74425583	T	T	74425583	3	4	190	1	0	0	0	0	1	0	0	0	7898	768	27	1	490	1	ISLR2	15	74425583	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	48463682	74425583	28105809	62	34965											
AP3B2	8120	broad.mit.edu	37	chr15	83331629	83331629	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcccctcgccagctacccGgtgcagcagctcctgccgcc	5	5	10	21	3	0	0	0	0	0	0	2	0	1	0	7	1	7	4	7	1	1	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr15:83331629G>A	uc010uoh.1	-	22	2770	c.2593C>T	c.(2593-2595)CGG>TGG	p.R865W	AP3B2_uc010uoi.1_Missense_Mutation_p.R884W|AP3B2_uc010uoj.1_Missense_Mutation_p.R833W|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Missense_Mutation_p.R501W	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	865					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			CCAGCTACCCGGTGCAGCAGC	0.607													5	24					0	0	0	0	A	83331629	A	A	83331629	3	1	190	1	0	0	0	0	1	0	0	0	745	1115	39	1	675	1	AP3B2	15	83331629	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	8906046	83331629	19199763	63	34966											
HS3ST6	64711	broad.mit.edu	37	chr16	1961723	1961737	+	In_Frame_Del	DEL	GCGGGGACGGCTGCC	-	-																															cccttggacttgcccaggcaGcggggacggctgccgccctg																								rs79686696	by1000genomes	TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr16:1961723_1961737delGCGGGGACGGCTGCC	uc002cnf.2	-	2	790_804	c.790_804delGGCAGCCGTCCCCGC	c.(790-804)GGCAGCCGTCCCCGCdel	p.GSRPR264del		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	264_268											0						TGCCCAGGCAGCGGGGACGGCTGCCGCCCTGGGCC	0.679													---	---	---								-	1961737	-	-	1961723	7	5	190	1	0	1	0	1	0	0	0	0	7408	958	34	0	135	0	HS3ST6	16	1961723	In_Frame_Del	DEL	GCGGGGACGGCTGCC	TCGA-CV-6436-01A-11D-1683-08		1961723	88393030	64	34967											
GRIN2A	2903	broad.mit.edu	37	chr16	10032166	10032166	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagaagagtggatcttcttCagctggacttgtgtctttgc	8	14	11	8	0	4	2	1	0	3	2	4	4	4	4	0	2	2	1	0	2	1	4			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr16:10032166C>T	uc002czo.3	-	3	1205	c.657G>A	c.(655-657)CTG>CTA	p.L219L	GRIN2A_uc010uym.1_Silent_p.L219L|GRIN2A_uc010uyn.1_Silent_p.L62L|GRIN2A_uc002czr.3_Silent_p.L219L	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	219	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGATCTTCTTCAGCTGGACTT	0.507													8	49					0	0	0	0	T	10032166	T	T	10032166	2	4	190	1	0	0	0	0	0	0	0	1	6818	813	29	2		2	GRIN2A	16	10032166	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08	8070443	10032166	80322587	65	34968											
PDILT	204474	broad.mit.edu	37	chr16	20410538	20410538	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggttatgtggatgctggAaacaccggcgttaacctctg	8	12	12	9	2	1	0	0	0	1	0	1	2	1	2	2	4	3	3	2	4	3	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr16:20410538A>G	uc002dhc.1	-	2	308	c.85T>C	c.(85-87)TCC>CCC	p.S29P		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	29					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TGGATGCTGGAAACACCGGCG	0.602													25	109					0	0	0	0	G	20410538	G	G	20410538	3	3	190	1	0	0	0	0	1	0	0	0	11728	246	9	5	1713	5	PDILT	16	20410538	Missense_Mutation	SNP	A	TCGA-CV-6436-01A-11D-1683-08	10378372	20410538	69944215	66	34969											
C16orf78	123970	broad.mit.edu	37	chr16	49430551	49430551	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accgaacctaagatggaaacCatgaggatgttgaagccaga	16	6	11	8	1	0	4	0	2	0	2	0	7	0	6	4	2	3	1	4	2	4	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr16:49430551C>T	uc002efr.2	+	4	655	c.612C>T	c.(610-612)ACC>ACT	p.T204T		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	204										central_nervous_system(1)	1						AGATGGAAACCATGAGGATGT	0.542													5	28					0	0	0	0	T	49430551	T	T	49430551	2	4	190	1	0	0	0	0	0	0	0	1	1841	581	21	4		4	C16orf78	16	49430551	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08	29020013	49430551	40924202	67	34970											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	12	6	8	15	2	1	0	1	0	0	0	3	1	3	1	3	2	2	4	3	2	2	1	rs28934576	by1000genomes	TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	25					0	0	0	0	T	7577120	T	T	7577120	3	4	190	1	0	0	0	0	1	0	0	0	16448	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08		7577120	73618090	68	34971											
DNAH2	146754	broad.mit.edu	37	chr17	7673916	7673916	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctgggatgtgactcagctCgacatagtaccctacaagga	12	8	10	11	1	1	1	1	1	0	0	2	4	1	3	2	2	3	2	2	2	4	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr17:7673916C>T	uc002giu.1	+	25	4154	c.4140C>T	c.(4138-4140)CTC>CTT	p.L1380L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1380	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGACTCAGCTCGACATAGTAC	0.542													13	53					0	0	0	0	T	7673916	T	T	7673916	2	4	190	1	0	0	0	0	0	0	0	1	4624	871	31	1		1	DNAH2	17	7673916	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08	96796	7673916	73521294	69	34972											
FAM134C	162427	broad.mit.edu	37	chr17	40735595	40735595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggtggagagctctgcggCgtactgtgggaagagcacaa	9	7	17	8	2	1	2	0	0	1	2	1	4	1	3	0	4	4	3	0	4	3	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr17:40735595C>T	uc002ial.2	-	7	834	c.731G>A	c.(730-732)CGC>CAC	p.R244H	FAM134C_uc010wgq.1_Missense_Mutation_p.R44H|FAM134C_uc002iam.1_Missense_Mutation_p.R44H|FAM134C_uc010cyk.1_Missense_Mutation_p.R147H	NM_178126	NP_835227	Q86VR2	F134C_HUMAN	hypothetical protein LOC162427	244						integral to membrane		p.R244H(1)		upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		AGCTCTGCGGCGTACTGTGGG	0.498													10	27					0	0	0	0	T	40735595	T	T	40735595	3	4	190	1	0	0	0	0	1	0	0	0	5475	768	27	1	681	1	FAM134C	17	40735595	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	33061679	40735595	40459615	70	34973											
CBX4	8535	broad.mit.edu	37	chr17	77807811	77807811	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggcagttcgcggtgacgtCggtgataattatattcccaa	10	11	12	8	4	0	2	0	2	0	0	3	3	1	2	1	3	0	2	1	3	4	5			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr17:77807811C>T	uc002jxe.2	-	5	1793	c.1630G>A	c.(1630-1632)GAC>AAC	p.D544N		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	544	Interaction with RNF2.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GCGGTGACGTCGGTGATAATT	0.627													22	65					0	0	0	0	T	77807811	T	T	77807811	3	4	190	1	0	0	0	0	1	0	0	0	2732	884	31	1	56	1	CBX4	17	77807811	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	37072216	77807811	3387399	71	34974											
ST8SIA5	29906	broad.mit.edu	37	chr18	44260048	44260048	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgcacgcggaggatgcctCggctgtgcaagtgcaggaag	8	7	17	9	3	0	0	0	0	0	0	1	3	0	3	1	4	4	4	1	4	2	0			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr18:44260048C>T	uc002lcj.1	-	7	1656	c.1088G>A	c.(1087-1089)CGA>CAA	p.R363Q	ST8SIA5_uc002lci.1_Missense_Mutation_p.R210Q|ST8SIA5_uc010xcy.1_Missense_Mutation_p.R399Q|ST8SIA5_uc010xcz.1_Missense_Mutation_p.R332Q	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	363	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane		p.R363Q(1)		upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GAGGATGCCTCGGCTGTGCAA	0.647													17	55					0	0	0	0	T	44260048	T	T	44260048	3	4	190	1	0	0	0	0	1	0	0	0	15301	884	31	1	46	1	ST8SIA5	18	44260048	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08		44260048	33817200	72	34975											
OAZ1	4946	broad.mit.edu	37	chr19	2271954	2271954	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccgaggggagcaaggacagGtgaggggcaaggacaggcag	12	1	20	8	1	0	1	0	1	0	0	0	5	0	4	1	8	1	3	1	8	2	0			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr19:2271954G>A	uc002lvl.2	+	3		c.543_splice	c.e3+1		OAZ1_uc002lvm.2_Splice_Site|SPPL2B_uc010dsw.1_Intron			P54368	OAZ1_HUMAN	Homo sapiens cDNA, FLJ97169.						polyamine biosynthetic process|regulation of cellular amino acid metabolic process	cytosol	ornithine decarboxylase inhibitor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	L-Ornithine(DB00129)	GCAAGGACAGGTGAGGGGCAA	0.667													5	12					0	0	0	0	A	2271954	A	A	2271954	5	1	190	1	0	0	0	0	0	0	1	0	10858	1275	44	4	476	4	OAZ1	19	2271954	Splice_Site	SNP	G	TCGA-CV-6436-01A-11D-1683-08		2271954	56857029	73	34976											
TMEM146	257062	broad.mit.edu	37	chr19	5772836	5772836	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggaggtcatcgacgccGagtatgtgttactggaggtg	8	10	15	8	3	1	0	1	0	0	0	3	4	2	2	2	4	1	2	2	4	2	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr19:5772836G>T	uc002mda.2	+	20	1862	c.1801G>T	c.(1801-1803)GAG>TAG	p.E601*		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	601	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CATCGACGCCGAGTATGTGTT	0.607													22	69					2.98393e-07	3.39083e-07	1	0	T	5772836	T	T	5772836	4	4	190	1	0	0	0	0	0	1	0	0	16126	1059	37	3	1879	3	TMEM146	19	5772836	Nonsense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	3500882	5772836	53356147	74	34977											
MUC16	94025	broad.mit.edu	37	chr19	9000504	9000504	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccagggtgatgcatgttctCctcataccgcaggttagtga	8	11	12	10	1	2	2	1	2	1	0	3	2	2	2	3	2	2	4	3	2	2	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr19:9000504C>T	uc002mkp.2	-	54	40684	c.40480G>A	c.(40480-40482)GAG>AAG	p.E13494K	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.E311K|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13496	SEA 10.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGCATGTTCTCCTCATACCGC	0.478													11	48					0	0	0	0	T	9000504	T	T	9000504	3	4	190	1	0	0	0	0	1	0	0	0	10026	864	30	2	3167	2	MUC16	19	9000504	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	3227668	9000504	50128479	75	34978											
CYP4F3	4051	broad.mit.edu	37	chr19	15769113	15769113	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccttcctgaccatgtgcatTaaggagagcctgaggctgca	9	9	11	12	0	0	3	0	2	0	1	1	4	1	3	4	2	3	3	4	2	1	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr19:15769113T>C	uc002nbj.2	+	10	1205	c.1155T>C	c.(1153-1155)ATT>ATC	p.I385I	CYP4F3_uc010xok.1_Silent_p.I385I|CYP4F3_uc010xol.1_Silent_p.I385I|CYP4F3_uc010xom.1_Silent_p.I236I|CYP4F3_uc002nbk.2_Silent_p.I385I|CYP4F3_uc010xon.1_Silent_p.I95I	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	385					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						CCATGTGCATTAAGGAGAGCC	0.597													4	102					0	0	0	0	C	15769113	C	C	15769113	2	2	190	1	0	0	0	0	0	0	0	1	4207	1742	61	5		5	CYP4F3	19	15769113	Silent	SNP	T	TCGA-CV-6436-01A-11D-1683-08	6768609	15769113	43359870	76	34979											
ZNF529	57711	broad.mit.edu	37	chr19	37039185	37039185	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgttttgaataatatcttttCctacagataaatgcttagtc	12	18	5	6	0	1	2	0	1	1	1	3	2	2	2	1	0	2	2	1	0	7	9			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr19:37039185C>T	uc002oeh.3	-	5	477	c.275G>A	c.(274-276)GGA>GAA	p.G92E	ZNF529_uc010xth.1_Missense_Mutation_p.G92E|ZNF529_uc010xti.1_Missense_Mutation_p.G74E|ZNF529_uc002oeg.3_5'UTR	NM_020951	NP_066002	Q6P280	ZN529_HUMAN	zinc finger protein 529 isoform a	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					AATATCTTTTCCTACAGATAA	0.343													4	15					0	0	0	0	T	37039185	T	T	37039185	3	4	190	1	0	0	0	0	1	0	0	0	18037	855	30	2	1420	2	ZNF529	19	37039185	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	21270072	37039185	22089798	77	34980											
DYRK1B	9149	broad.mit.edu	37	chr19	40321135	40321137	+	In_Frame_Del	DEL	CTC	-	-																															ccatggttcaggaccttcttCtccttcttgttgctcgaatc																										TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr19:40321135_40321137delCTC	uc002omj.2	-	4	530_532	c.250_252delGAG	c.(250-252)GAGdel	p.E84del	DYRK1B_uc002omi.2_In_Frame_Del_p.E84del|DYRK1B_uc002omk.2_In_Frame_Del_p.E84del|DYRK1B_uc002oml.2_In_Frame_Del_p.E84del	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	84	Bipartite nuclear localization signal (Potential).				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			GGACCTTCTTCTCCTTCTTGTTG	0.581													---	---	---								-	40321137	-	-	40321135	7	5	190	1	0	1	0	1	0	0	0	0	4877	912	32	0	1669	0	DYRK1B	19	40321135	In_Frame_Del	DEL	CTC	TCGA-CV-6436-01A-11D-1683-08	3281950	40321135	18807848	78	34981											
CCDC8	83987	broad.mit.edu	37	chr19	46914919	46914919	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatctgcagcctcttccctGtggttatctgtgccctgtga	4	16	9	12	0	3	1	0	1	3	0	4	1	4	1	3	1	3	2	3	1	2	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr19:46914919G>C	uc002pep.2	-	1	2001	c.1149C>G	c.(1147-1149)CAC>CAG	p.H383Q		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	383						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CCTCTTCCCTGTGGTTATCTG	0.582													42	136					0	0	0	0	C	46914919	C	C	46914919	3	2	190	1	0	0	0	0	1	0	0	0	2866	1368	48	4	471	4	CCDC8	19	46914919	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	6593784	46914919	12214064	79	34982											
ZNF614	80110	broad.mit.edu	37	chr19	52519599	52519599	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctcctgtatgagttcgctGatgtataacgagagtgcgtt	8	14	11	8	3	1	3	0	2	1	1	3	4	1	3	1	0	2	5	1	0	3	5			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr19:52519599G>A	uc002pyj.2	-	5	1654	c.1252C>T	c.(1252-1254)CAG>TAG	p.Q418*	ZNF614_uc002pyi.3_Intron|ZNF614_uc010epj.2_Nonsense_Mutation_p.Q121*	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	418	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Q418*(1)		ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TGAGTTCGCTGATGTATAACG	0.423													38	144					0	0	0	0	A	52519599	A	A	52519599	4	1	190	1	0	0	0	0	0	1	0	0	18106	1299	45	2	509	2	ZNF614	19	52519599	Nonsense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08	5604680	52519599	6609384	80	34983											
PTPRA	5786	broad.mit.edu	37	chr20	2969023	2969023	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctggccagatccccaagcaCcaacaggaaatacccacccc	13	4	6	18	0	1	1	0	0	1	1	2	2	2	2	7	2	3	1	7	2	4	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr20:2969023C>T	uc010zqd.1	+	8	991	c.674C>T	c.(673-675)ACC>ATC	p.T225I	PTPRA_uc002whj.2_Missense_Mutation_p.T214I|PTPRA_uc010zqc.1_Missense_Mutation_p.T99I|PTPRA_uc002whk.2_Missense_Mutation_p.T205I|PTPRA_uc002whl.2_Missense_Mutation_p.T205I|PTPRA_uc002whm.2_5'UTR|PTPRA_uc002whn.2_Missense_Mutation_p.T205I|PTPRA_uc002who.2_5'UTR	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	214	Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity	p.T214I(1)		upper_aerodigestive_tract(1)	1						TCCCCAAGCACCAACAGGAAA	0.547													15	56					0	0	0	0	T	2969023	T	T	2969023	3	4	190	1	0	0	0	0	1	0	0	0	12860	507	18	4	663	4	PTPRA	20	2969023	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08		2969023	60056497	81	34984											
DIDO1	11083	broad.mit.edu	37	chr20	61511734	61511734	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccgtcacctcgttatacggGgcgtcctggaactccctctt	5	11	9	16	4	2	0	1	0	1	0	5	1	4	1	4	3	2	1	4	3	3	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr20:61511734G>A	uc002ydr.1	-	16	5838	c.5574C>T	c.(5572-5574)GCC>GCT	p.A1858A	DIDO1_uc002yds.1_Silent_p.A1858A	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1858	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CGTTATACGGGGCGTCCTGGA	0.622													20	79					0	0	0	0	A	61511734	A	A	61511734	2	1	190	1	0	0	0	0	0	0	0	1	4544	1219	43	4		4	DIDO1	20	61511734	Silent	SNP	G	TCGA-CV-6436-01A-11D-1683-08	58542711	61511734	1513786	82	34985											
ARVCF	421	broad.mit.edu	37	chr22	19960526	19960526	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccacactgtctgcagcacGtgtgacgccgccttcgcttc	5	10	9	17	4	1	1	0	1	1	0	4	1	2	1	3	0	2	3	3	0	0	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr22:19960526G>A	uc002zqz.2	-	15	2743	c.2472C>T	c.(2470-2472)CAC>CAT	p.H824H	ARVCF_uc002zqy.2_Silent_p.H340H	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	824	ARM 10.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TCTGCAGCACGTGTGACGCCG	0.672													27	65					0	0	0	0	A	19960526	A	A	19960526	2	1	190	1	0	0	0	0	0	0	0	1	1005	1136	40	1		1	ARVCF	22	19960526	Silent	SNP	G	TCGA-CV-6436-01A-11D-1683-08		19960526	31344040	83	34986											
SLC5A4	6527	broad.mit.edu	37	chr22	32614659	32614659	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgggtcccttctgcaaacCgcagaacaagtcataagctt	11	10	8	12	1	2	1	1	0	1	1	3	1	3	1	2	1	4	3	2	1	4	4	rs150790454		TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr22:32614659C>T	uc003ami.2	-	15	1824	c.1822G>A	c.(1822-1824)GGT>AGT	p.G608S		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	608	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						TTCTGCAAACCGCAGAACAAG	0.468													9	59					0	0	0	0	T	32614659	T	T	32614659	3	4	190	1	0	0	0	0	1	0	0	0	14731	652	23	1	161	1	SLC5A4	22	32614659	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	12654133	32614659	18689907	84	34987											
TRIOBP	11078	broad.mit.edu	37	chr22	38121554	38121554	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcctcacctgtgtacccCgctgcctatggggctcccct	4	11	8	18	1	1	0	1	0	0	0	3	0	3	0	7	2	2	3	7	2	2	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr22:38121554C>T	uc003atr.2	+	7	3262	c.2991C>T	c.(2989-2991)CCC>CCT	p.P997P	TRIOBP_uc003atu.2_Silent_p.P825P|TRIOBP_uc003atq.1_Silent_p.P997P|TRIOBP_uc003ats.1_Silent_p.P825P	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	997					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CTGTGTACCCCGCTGCCTATG	0.652													25	124					0	0	0	0	T	38121554	T	T	38121554	2	4	190	1	0	0	0	0	0	0	0	1	16620	639	23	1		1	TRIOBP	22	38121554	Silent	SNP	C	TCGA-CV-6436-01A-11D-1683-08	5506895	38121554	13183012	85	34988											
ZC3H7B	23264	broad.mit.edu	37	chr22	41753277	41753277	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggaccggcgcgaggtgctGaagcagaagttggccaaggc	9	5	17	10	3	0	2	0	1	0	1	0	4	0	3	2	5	2	3	2	5	3	1			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chr22:41753277G>C	uc003azw.2	+	23	2994	c.2778G>C	c.(2776-2778)CTG>CTC	p.L926L	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	942	Potential.				interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						GCGAGGTGCTGAAGCAGAAGT	0.617													13	88					0	0	0	0	C	41753277	C	C	41753277	2	2	190	1	0	0	0	0	0	0	0	1	17640	1277	45	2		2	ZC3H7B	22	41753277	Silent	SNP	G	TCGA-CV-6436-01A-11D-1683-08	3631723	41753277	9551289	86	34989											
MAGT1	84061	broad.mit.edu	37	chrX	77126359	77126359	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accatggcaaaaaatatcctGttggtgaatgcactggagta	14	10	10	7	0	0	1	0	1	0	0	1	2	1	2	2	3	1	4	2	3	6	3			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chrX:77126359G>C	uc004fof.2	-	3	494	c.432C>G	c.(430-432)AAC>AAG	p.N144K	MAGT1_uc004fog.3_RNA|MAGT1_uc004ect.3_Missense_Mutation_p.N144K	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	112					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex		p.N112K(1)		upper_aerodigestive_tract(1)	1						AAAATATCCTGTTGGTGAATG	0.363													15	26					0	0	0	0	C	77126359	C	C	77126359	3	2	190	1	0	0	0	0	1	0	0	0	9249	1368	48	4	703	4	MAGT1	23	77126359	Missense_Mutation	SNP	G	TCGA-CV-6436-01A-11D-1683-08		77126359	78144201	87	34990											
WDR44	54521	broad.mit.edu	37	chrX	117575441	117575441	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatggtcagacaaaattgatCacagctgcaaatttctgtca	14	11	8	8	0	4	2	3	1	1	1	4	3	4	2	0	1	2	2	0	1	3	2			TCGA-CV-6436-01A-11D-1683-08	TCGA-CV-6436-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5214457-3a86-4b29-b116-3baaa0aa5099	52a510f4-866c-4471-a03b-a406c75f544f	g.chrX:117575441C>G	uc004eqn.2	+	15	2510	c.2085C>G	c.(2083-2085)ATC>ATG	p.I695M	WDR44_uc004eqo.2_Missense_Mutation_p.I695M|WDR44_uc011mtr.1_Intron|WDR44_uc010nqi.2_Missense_Mutation_p.I405M	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	695	WD 4.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm		p.I695M(2)		lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						CAAAATTGATCACAGCTGCAA	0.378													26	31					0	0	0	0	G	117575441	G	G	117575441	3	3	190	1	0	0	0	0	1	0	0	0	17364	816	29	2	2143	2	WDR44	23	117575441	Missense_Mutation	SNP	C	TCGA-CV-6436-01A-11D-1683-08	40449082	117575441	37695119	88	34991											
NPHP4	261734	broad.mit.edu	37	chr1	5993234	5993237	+	Frame_Shift_Del	DEL	TACC	-	-																															gagctcatgctggctgagggTaccttgtagaccagacagtg																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:5993234_5993237delTACC	uc001alq.1	-	10	1538_1541	c.1272_1275delGGTA	c.(1270-1275)AAGGTAfs	p.K424fs	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_RNA|NPHP4_uc001alt.1_RNA	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	424_425					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TGGCTGAGGGTACCTTGTAGACCA	0.5													---	---	---								-	5993237	-	-	5993234	7	5	191	1	0	1	0	1	0	0	0	0	10635	1625	57	0	3089	0	NPHP4	1	5993234	Frame_Shift_Del	DEL	TACC	TCGA-CV-6441-01A-11D-1683-08		5993234	243257387	1	34992											
PHF13	148479	broad.mit.edu	37	chr1	6680226	6680226	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctcccagcgacccctgcTcgggctgggactccgatact	6	7	12	16	3	0	0	0	0	0	0	3	3	2	1	4	3	3	3	4	3	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:6680226T>G	uc001aob.3	+	3	876	c.505T>G	c.(505-507)TCG>GCG	p.S169A		NM_153812	NP_722519	Q86YI8	PHF13_HUMAN	PHD finger protein 13	169					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		CGACCCCTGCTCGGGCTGGGA	0.597													16	31					0	0	0	0	G	6680226	G	G	6680226	3	3	191	1	0	0	0	0	1	0	0	0	11879	1551	54	5	515	5	PHF13	1	6680226	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	686992	6680226	242570395	2	34993											
RHD	6007	broad.mit.edu	37	chr1	25611200	25611200	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgggcaatcctgctggaCggcttcctgagccagttccc	6	9	12	14	1	0	1	0	1	0	0	3	2	3	2	4	3	2	4	4	3	1	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:25611200C>T	uc001bjz.2	+	2	343	c.285C>T	c.(283-285)GAC>GAT	p.D95D	RHD_uc010oep.1_Silent_p.D95D|RHD_uc001bkc.2_Silent_p.D95D|RHD_uc009vrm.2_Translation_Start_Site|RHD_uc001bka.2_Silent_p.D95D|RHD_uc001bkb.2_Silent_p.D95D|RHD_uc009vrn.2_Silent_p.D95D|RHD_uc009vro.2_Silent_p.D95D|RHD_uc009vrp.2_Silent_p.D95D	NM_016124	NP_057208	Q02161	RHD_HUMAN	Rh blood group D antigen isoform 1	95	Helical; (Potential).					integral to plasma membrane				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCCTGCTGGACGGCTTCCTGA	0.572													5	53					0	0	0	0	T	25611200	T	T	25611200	2	4	191	1	0	0	0	0	0	0	0	1	13392	535	19	1		1	RHD	1	25611200	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	18930974	25611200	223639421	3	34994											
DCDC2B	149069	broad.mit.edu	37	chr1	32677785	32677785	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgagaaggtcaagttgcaGagtggggctgtgtgcaagtg	10	9	17	5	0	1	2	1	1	0	2	1	3	1	2	0	3	2	4	0	3	3	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:32677785G>C	uc001bun.2	+	4	510	c.510G>C	c.(508-510)CAG>CAC	p.Q170H		NM_001099434	NP_001092904	A2VCK2	DCD2B_HUMAN	doublecortin domain containing 2B	170	Doublecortin 2.				intracellular signal transduction						0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TCAAGTTGCAGAGTGGGGCTG	0.577													8	87					0	0	0	0	C	32677785	C	C	32677785	3	2	191	1	0	0	0	0	1	0	0	0	4303	933	33	2	524	2	DCDC2B	1	32677785	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	7066585	32677785	216572836	4	34995											
EIF2C1	26523	broad.mit.edu	37	chr1	36367908	36367909	+	Missense_Mutation	DNP	CC	TA	TA																															ggccatcgcctgcttcgcacCccaaaaacagtgtcgagaag																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:36367908_36367909CC>TA	uc001bzl.2	+	11	1580_1581	c.1367_1368CC>TA	c.(1366-1368)CCC>CTA	p.P456L	EIF2C1_uc001bzk.2_Missense_Mutation_p.P381L|EIF2C1_uc009vuy.2_Intron	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	456					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGCTTCGCACCCCAAAAACAGT	0.574													20	53					0	0	0	0	TA	36367909	TA	TA	36367908	3	4	191	1	0	0	0	0	1	0	0	0	5027	623	22	4	1409	4	EIF2C1	1	36367908	Missense_Mutation	DNP	CC	TCGA-CV-6441-01A-11D-1683-08	3690123	36367908	212882713	5	34996											
HEYL	26508	broad.mit.edu	37	chr1	40092678	40092678	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagggccagtgggcgtgggcGaaggctccatctcggctgcg	6	6	18	11	4	1	0	0	0	1	0	3	1	2	0	2	5	1	2	2	5	2	0	rs139668981	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:40092678G>A	uc001cdp.2	-	5	539	c.488C>T	c.(487-489)TCG>TTG	p.S163L	HEYL_uc010oiw.1_Missense_Mutation_p.S135L	NM_014571	NP_055386	Q9NQ87	HEYL_HUMAN	hairy/enhancer-of-split related with YRPW	163	Pro-rich.				multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GGGCGTGGGCGAAGGCTCCAT	0.652													15	36					0	0	0	0	A	40092678	A	A	40092678	3	1	191	1	0	0	0	0	1	0	0	0	7119	1059	37	1	502	1	HEYL	1	40092678	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	3724770	40092678	209157943	6	34997											
RLF	6018	broad.mit.edu	37	chr1	40701683	40701683	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaactatatttgcaaccaGatcaaaaatttgatgaagaa	20	10	6	5	0	1	5	1	2	0	3	1	5	1	5	1	0	3	1	1	0	9	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:40701683G>C	uc001cfc.3	+	8	1340	c.1309G>C	c.(1309-1311)GAT>CAT	p.D437H	RLF_uc001cfd.3_Missense_Mutation_p.D128H	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	437					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TTTGCAACCAGATCAAAAATT	0.368													23	111					0	0	0	0	C	40701683	C	C	40701683	3	2	191	1	0	0	0	0	1	0	0	0	13454	942	33	2	1339	2	RLF	1	40701683	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	609005	40701683	208548938	7	34998											
AK5	26289	broad.mit.edu	37	chr1	77752661	77752661	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgatgtgttctaagcccgaAgatccagtagaatacttgga	12	11	10	8	1	1	3	0	1	1	2	2	5	2	4	2	1	2	2	2	1	5	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:77752661A>C	uc001dhn.2	+	2	353	c.96A>C	c.(94-96)GAA>GAC	p.E32D	AK5_uc001dho.2_Missense_Mutation_p.E6D|AK5_uc001dhm.1_Missense_Mutation_p.E32D	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	32					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						CTAAGCCCGAAGATCCAGTAG	0.338													34	44					0	0	0	0	C	77752661	C	C	77752661	3	2	191	1	0	0	0	0	1	0	0	0	443	69	3	5	102	5	AK5	1	77752661	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	37050978	77752661	171497960	8	34999											
SYDE2	84144	broad.mit.edu	37	chr1	85630216	85630216	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagaatcatttacctggccaGagttggagtaagtaatgaag	14	11	11	5	0	1	3	1	1	0	2	1	4	1	4	2	2	1	3	2	2	6	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:85630216G>A	uc009wcm.2	-	6	3127	c.3078C>T	c.(3076-3078)CTC>CTT	p.L1026L		NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	1026	Rho-GAP.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		TACCTGGCCAGAGTTGGAGTA	0.318													5	11					0	0	0	0	A	85630216	A	A	85630216	2	1	191	1	0	0	0	0	0	0	0	1	15502	929	33	2		2	SYDE2	1	85630216	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	7877555	85630216	163620405	9	35000											
HFM1	164045	broad.mit.edu	37	chr1	91861862	91861862	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taatttacctaacagtttatGactttctaattcttcctcta	11	19	2	9	0	3	1	0	1	3	0	4	1	4	1	2	0	2	1	2	0	6	11			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:91861862G>A	uc001doa.3	-	3	272	c.172C>T	c.(172-174)CAT>TAT	p.H58Y	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.H58Y	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	58							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AACAGTTTATGACTTTCTAAT	0.303													7	26					0	0	0	0	A	91861862	A	A	91861862	3	1	191	1	0	0	0	0	1	0	0	0	7122	1290	45	2	4283	2	HFM1	1	91861862	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	6231646	91861862	157388759	10	35001											
COL11A1	1301	broad.mit.edu	37	chr1	103480096	103480096	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaagaatagcttgagcctGagcttcctgagcagagatgg	11	9	13	8	0	0	6	0	4	0	2	1	7	1	6	2	1	4	3	2	1	3	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:103480096G>A	uc001dul.2	-	13	1861	c.1543C>T	c.(1543-1545)CAG>TAG	p.Q515*	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Nonsense_Mutation_p.Q527*|COL11A1_uc001dun.2_Nonsense_Mutation_p.Q476*|COL11A1_uc009weh.2_Nonsense_Mutation_p.Q399*	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	515	Telopeptide.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCTTGAGCCTGAGCTTCCTGA	0.418													7	33					0	0	0	0	A	103480096	A	A	103480096	4	1	191	1	0	0	0	0	0	1	0	0	3682	1299	45	2	4097	2	COL11A1	1	103480096	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	11618234	103480096	145770525	11	35002											
NTNG1	22854	broad.mit.edu	37	chr1	107691398	107691398	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acggacatgacaaaatatctGaaagtgaaactcgatcctcc	16	8	7	10	2	1	3	0	3	1	0	4	5	3	4	2	1	1	0	2	1	5	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:107691398G>A	uc001dvh.3	+	2	901	c.183G>A	c.(181-183)CTG>CTA	p.L61L	NTNG1_uc001dvf.3_Silent_p.L61L|NTNG1_uc010out.1_Silent_p.L61L|NTNG1_uc001dvc.3_Silent_p.L61L|NTNG1_uc001dvd.1_Silent_p.L61L	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	61	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CAAAATATCTGAAAGTGAAAC	0.423													21	96					0	0	0	0	A	107691398	A	A	107691398	2	1	191	1	0	0	0	0	0	0	0	1	10758	1277	45	2		2	NTNG1	1	107691398	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	4211302	107691398	141559223	12	35003											
GPR61	83873	broad.mit.edu	37	chr1	110086037	110086037	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgtcagcctggccatcctCtcggtgtcagccatcaatgt	6	13	9	13	1	4	0	3	0	1	0	6	0	5	0	4	2	2	0	4	2	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:110086037C>G	uc001dxy.2	+	2	1076	c.393C>G	c.(391-393)CTC>CTG	p.L131L		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	131	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		TGGCCATCCTCTCGGTGTCAG	0.607													22	92					0	0	0	0	G	110086037	G	G	110086037	2	3	191	1	0	0	0	0	0	0	0	1	6740	900	32	2		2	GPR61	1	110086037	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	2394639	110086037	139164584	13	35004											
SPAG17	200162	broad.mit.edu	37	chr1	118693935	118693935	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacggtaagggcttggatgaGaagatcatcttcaatctggt	11	11	12	7	1	4	2	2	1	2	2	4	4	4	3	0	4	0	2	0	4	3	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:118693935G>C	uc001ehk.2	-	2	213	c.145C>G	c.(145-147)CTC>GTC	p.L49V		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	49						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GCTTGGATGAGAAGATCATCT	0.453													8	41					0	0	0	0	C	118693935	C	C	118693935	3	2	191	1	0	0	0	0	1	0	0	0	15045	942	33	2	6714	2	SPAG17	1	118693935	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	8607898	118693935	130556686	14	35005											
NBPF10	100132406	broad.mit.edu	37	chr1	145301812	145301812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagcagctcaagcaagctGaggagctcaggtgaggggac	12	4	16	9	0	2	3	2	2	0	1	2	5	2	5	0	4	5	5	0	4	2	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:145301812G>A	uc001end.3	+	7	1116	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.E361K|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Missense_Mutation_p.E90K	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	361											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CAAGCAAGCTGAGGAGCTCAG	0.522													28	183					0	0	0	0	A	145301812	A	A	145301812	3	1	191	1	0	0	0	0	1	0	0	0	10246	1291	45	2	1107	2	NBPF10	1	145301812	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	26607877	145301812	103948809	15	35006											
ITGA10	8515	broad.mit.edu	37	chr1	145536002	145536002	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcctccttcattcagacatGaggttcaccgcatcactgga	9	11	8	13	1	4	2	4	1	0	1	5	3	5	3	3	2	1	2	3	2	0	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:145536002G>C	uc001eoa.2	+	17	2170	c.2094G>C	c.(2092-2094)ATG>ATC	p.M698I	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.M567I|ITGA10_uc009wiw.2_Missense_Mutation_p.M555I|ITGA10_uc010oyw.1_Missense_Mutation_p.M643I	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	698	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATTCAGACATGAGGTTCACCG	0.542													30	108					0	0	0	0	C	145536002	C	C	145536002	3	2	191	1	0	0	0	0	1	0	0	0	7912	1290	45	2	2160	2	ITGA10	1	145536002	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	234190	145536002	103714619	16	35007											
TUFT1	7286	broad.mit.edu	37	chr1	151552206	151552206	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatcgcctatctggaggcaGaggtgtgtgtgctgggcagc	8	9	16	8	1	1	1	0	0	1	1	2	2	1	2	1	4	2	3	1	4	2	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:151552206G>C	uc001eyl.2	+	11	1068	c.1006G>C	c.(1006-1008)GAG>CAG	p.E336Q	TUFT1_uc001eym.2_Missense_Mutation_p.E311Q|TUFT1_uc010pdf.1_Missense_Mutation_p.E355Q|TUFT1_uc010pdg.1_Missense_Mutation_p.E284Q	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1	336	Potential.				bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCTGGAGGCAGAGGTGTGTGT	0.532													5	12					0	0	0	0	C	151552206	C	C	151552206	3	2	191	1	0	0	0	0	1	0	0	0	16840	943	33	2	1048	2	TUFT1	1	151552206	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	6016204	151552206	97698415	17	35008											
ADAR	103	broad.mit.edu	37	chr1	154573540	154573540	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttcatggggtggtccactCtgctctatcatgttgaactc	6	14	11	10	0	4	1	2	1	2	0	6	1	5	1	1	4	2	3	1	4	2	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:154573540C>T	uc001ffh.2	-	2	1778	c.1578G>A	c.(1576-1578)CAG>CAA	p.Q526Q	ADAR_uc001ffj.2_Silent_p.Q526Q|ADAR_uc001ffi.2_Silent_p.Q526Q|ADAR_uc001ffk.2_Silent_p.Q231Q|ADAR_uc001ffl.1_Silent_p.Q231Q	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	526	DRBM 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GTGGTCCACTCTGCTCTATCA	0.517													18	97					0	0	0	0	T	154573540	T	T	154573540	2	4	191	1	0	0	0	0	0	0	0	1	281	912	32	2		2	ADAR	1	154573540	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	3021334	154573540	94677081	18	35009											
TRIM46	80128	broad.mit.edu	37	chr1	155156625	155156625	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccagtgggcactaagcctGagaggaaagtcaccattggg	12	6	14	9	0	1	1	1	1	0	1	1	3	1	2	3	3	2	1	3	3	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:155156625G>A	uc001fhs.1	+	10	2322	c.2239G>A	c.(2239-2241)GAG>AAG	p.E747K	RAG1AP1_uc010pey.1_Intron|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Missense_Mutation_p.E621K|TRIM46_uc001fhu.1_Missense_Mutation_p.E724K|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	747	B30.2/SPRY.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CACTAAGCCTGAGAGGAAAGT	0.642													5	23					0	0	0	0	A	155156625	A	A	155156625	3	1	191	1	0	0	0	0	1	0	0	0	16588	1291	45	2	2277	2	TRIM46	1	155156625	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	583085	155156625	94093996	19	35010											
RAB25	57111	broad.mit.edu	37	chr1	156038115	156038115	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgacctaaccaagcaccaGacctatgctgtggtggagcg	10	9	11	11	1	0	2	0	1	0	1	0	3	0	3	4	2	4	2	4	2	3	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:156038115G>T	uc001fnc.2	+	3	520	c.294G>T	c.(292-294)CAG>CAT	p.Q98H		NM_020387	NP_065120	P57735	RAB25_HUMAN	RAB25	98					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					CCAAGCACCAGACCTATGCTG	0.547													68	77					9.5628e-27	1.08939e-26	1	0	T	156038115	T	T	156038115	3	4	191	1	0	0	0	0	1	0	0	0	12977	933	33	2	304	2	RAB25	1	156038115	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	881490	156038115	93212506	20	35011											
CD1B	910	broad.mit.edu	37	chr1	158300658	158300658	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatgtagactcggaatatctCctctaactcagcaacctcct	11	11	6	13	1	3	1	1	0	2	1	6	3	4	2	3	1	3	2	3	1	5	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:158300658C>G	uc001frx.2	-	2	364	c.256G>C	c.(256-258)GAG>CAG	p.E86Q	CD1B_uc001frw.2_5'UTR|CD1B_uc010pic.1_Missense_Mutation_p.E86Q	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	86	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					CGGAATATCTCCTCTAACTCA	0.458													79	311					0	0	0	0	G	158300658	G	G	158300658	3	3	191	1	0	0	0	0	1	0	0	0	2990	864	30	2	765	2	CD1B	1	158300658	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	2262543	158300658	90949963	21	35012											
OR6N1	128372	broad.mit.edu	37	chr1	158736156	158736156	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcactcagtcgctccaaggGagtgaaagaaatagatctgc	14	7	11	9	1	2	3	1	1	1	2	4	4	3	4	1	1	2	2	1	1	4	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:158736156G>T	uc010piq.1	-	1	317	c.317C>A	c.(316-318)TCC>TAC	p.S106Y		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CGCTCCAAGGGAGTGAAAGAA	0.502													12	34					5.50884e-06	5.788e-06	1	0	T	158736156	T	T	158736156	3	4	191	1	0	0	0	0	1	0	0	0	11260	1174	41	2	624	2	OR6N1	1	158736156	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	435498	158736156	90514465	22	35013											
TNN	63923	broad.mit.edu	37	chr1	175116116	175116116	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaattctccattccttacgTggagttgaaaatccgccctc	9	13	7	12	2	1	2	0	2	1	0	5	3	3	3	4	1	1	1	4	1	4	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:175116116T>C	uc001gkl.1	+	19	3922	c.3809T>C	c.(3808-3810)GTG>GCG	p.V1270A		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1270	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ATTCCTTACGTGGAGTTGAAA	0.522											OREG0013992	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	45					0	0	0	0	C	175116116	C	C	175116116	3	2	191	1	0	0	0	0	1	0	0	0	16389	1696	59	5	3879	5	TNN	1	175116116	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	16379960	175116116	74134505	23	35014											
TDRD5	163589	broad.mit.edu	37	chr1	179561846	179561846	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgagcccacaggagttggaGaaggagtaccttttgatggt	10	11	14	6	0	0	3	0	2	0	1	0	6	0	5	2	4	2	2	2	4	2	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:179561846G>C	uc001gnf.1	+	2	346	c.96G>C	c.(94-96)GAG>GAC	p.E32D	TDRD5_uc010pnp.1_Missense_Mutation_p.E32D|uc010pno.1_5'Flank	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	32	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						AGGAGTTGGAGAAGGAGTACC	0.478													23	106					0	0	0	0	C	179561846	C	C	179561846	3	2	191	1	0	0	0	0	1	0	0	0	15799	933	33	2	98	2	TDRD5	1	179561846	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	4445730	179561846	69688775	24	35015											
ZNF281	23528	broad.mit.edu	37	chr1	200377873	200377873	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aataaacttcatgctgcactGatcacatccaaatggcttct	13	12	5	11	0	3	1	2	1	1	0	4	1	4	1	1	1	3	3	1	1	4	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:200377873G>A	uc001gve.2	-	2	1068	c.961C>T	c.(961-963)CAG>TAG	p.Q321*	ZNF281_uc001gvf.1_Nonsense_Mutation_p.Q321*|ZNF281_uc001gvg.1_Nonsense_Mutation_p.Q285*	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	321	C2H2-type 3.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ATGCTGCACTGATCACATCCA	0.403													117	171					0	0	0	0	A	200377873	A	A	200377873	4	1	191	1	0	0	0	0	0	1	0	0	17885	1299	45	2	1730	2	ZNF281	1	200377873	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	20816027	200377873	48872748	25	35016											
LGR6	59352	broad.mit.edu	37	chr1	202287786	202287786	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcttcgcagacgggctcctCtactgtcccgtggccttcct	4	12	9	16	3	2	1	0	0	2	1	6	1	5	1	4	2	1	2	4	2	1	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:202287786C>G	uc001gxu.2	+	18	2355	c.2355C>G	c.(2353-2355)CTC>CTG	p.L785L	LGR6_uc001gxv.2_Silent_p.L733L|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Silent_p.L646L	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	785	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						ACGGGCTCCTCTACTGTCCCG	0.647													13	77					0	0	0	0	G	202287786	G	G	202287786	2	3	191	1	0	0	0	0	0	0	0	1	8799	900	32	2		2	LGR6	1	202287786	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	1909913	202287786	46962835	26	35017											
REN	5972	broad.mit.edu	37	chr1	204124994	204124994	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgtattctttgcctcccAggtggaaagagatgtcgggg	7	11	15	8	2	1	1	0	0	1	1	3	3	2	2	2	4	1	1	2	4	2	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:204124994A>G	uc001haq.2	-	9	1057	c.1013T>C	c.(1012-1014)CTG>CCG	p.L338P		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	338					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	TTTGCCTCCCAGGTGGAAAGA	0.572													5	27					0	0	0	0	G	204124994	G	G	204124994	3	3	191	1	0	0	0	0	1	0	0	0	13289	188	7	5	215	5	REN	1	204124994	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	1837208	204124994	45125627	27	35018											
ELK4	2005	broad.mit.edu	37	chr1	205589519	205589519	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagcttggatagtttcttCtgaagatggagaaatacttg	13	13	10	5	0	2	3	0	1	2	2	2	5	2	4	0	2	2	2	0	2	5	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:205589519C>G	uc001hcy.1	-	3	1905	c.655G>C	c.(655-657)GAA>CAA	p.E219Q	ELK4_uc001hcz.2_Missense_Mutation_p.E219Q	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	219						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			ATAGTTTCTTCTGAAGATGGA	0.473			T	SLC45A3	prostate								19	72					0	0	0	0	G	205589519	G	G	205589519	3	3	191	1	0	0	0	0	1	0	0	0	5085	922	32	2	790	2	ELK4	1	205589519	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	1464525	205589519	43661102	28	35019											
RASSF5	83593	broad.mit.edu	37	chr1	206760273	206760273	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtttaggcagaaactggAggaggccttaagagaatccc	14	7	12	8	0	0	2	0	0	0	2	1	5	1	4	2	4	1	2	2	4	5	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:206760273A>G	uc001hed.2	+	6	1277	c.1220A>G	c.(1219-1221)GAG>GGG	p.E407G	RASSF5_uc001hec.1_3'UTR|RASSF5_uc001hee.2_3'UTR|RASSF5_uc001hef.2_Missense_Mutation_p.E254G|RASSF5_uc001heg.1_3'UTR	NM_182663	NP_872604	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family 5	407	SARAH.				apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			ovary(1)	1	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CAGAAACTGGAGGAGGCCTTA	0.413													3	49					0	0	0	0	G	206760273	G	G	206760273	3	3	191	1	0	0	0	0	1	0	0	0	13154	304	11	5	1366	5	RASSF5	1	206760273	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	1170754	206760273	42490348	29	35020											
INTS7	25896	broad.mit.edu	37	chr1	212115325	212115325	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actataccattggcatctttCacagaagattccactgtaat	13	13	5	10	0	2	2	1	0	1	2	3	2	3	2	2	1	1	2	2	1	4	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:212115325C>T	uc001hiw.1	-	20	2835	c.2730G>A	c.(2728-2730)GTG>GTA	p.V910V	INTS7_uc009xdb.1_Silent_p.V890V|INTS7_uc001hix.1_Silent_p.V786V|INTS7_uc001hiy.1_Silent_p.V896V|INTS7_uc010pta.1_Silent_p.V861V	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	910					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TGGCATCTTTCACAGAAGATT	0.403													28	103					0	0	0	0	T	212115325	T	T	212115325	2	4	191	1	0	0	0	0	0	0	0	1	7822	813	29	2		2	INTS7	1	212115325	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	5355052	212115325	37135296	30	35021											
ITPKB	3707	broad.mit.edu	37	chr1	226925078	226925078	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcgtctcgctgccactggGccccgggccgccgccgctct	1	6	15	19	6	2	0	0	0	2	0	3	0	2	0	6	3	1	2	6	3	0	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr1:226925078G>A	uc010pvo.1	-	2	422	c.82C>T	c.(82-84)CCC>TCC	p.P28S	ITPKB_uc001hqh.2_Missense_Mutation_p.P28S	NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	28							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				CTGCCACTGGGCCCCGGGCCG	0.672													9	11					0	0	0	0	A	226925078	A	A	226925078	3	1	191	1	0	0	0	0	1	0	0	0	7957	1203	42	4	2786	4	ITPKB	1	226925078	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	14809753	226925078	22325543	31	35022											
RSAD2	91543	broad.mit.edu	37	chr2	7018158	7018158	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caccaccccaaccagcgtcaActatcacttcactcgccagt	11	7	4	19	2	3	0	3	0	0	0	4	0	3	0	5	0	3	0	5	0	3	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:7018158A>G	uc002qyp.1	+	1	363	c.227A>G	c.(226-228)AAC>AGC	p.N76S		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	76					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		ACCAGCGTCAACTATCACTTC	0.542													23	41					0	0	0	0	G	7018158	G	G	7018158	3	3	191	1	0	0	0	0	1	0	0	0	13760	43	2	5	229	5	RSAD2	2	7018158	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08		7018158	236181215	32	35023											
ZNF513	130557	broad.mit.edu	37	chr2	27600461	27600461	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccagcagtccccagggctGgtgggccccgagagctcaaa	8	5	14	14	1	1	1	1	0	0	1	2	2	2	1	5	3	3	3	5	3	1	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:27600461G>T	uc002rkk.2	-	4	1777	c.1577C>A	c.(1576-1578)CCA>CAA	p.P526Q	ZNF513_uc002rkj.2_Missense_Mutation_p.P464Q	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	526					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCAGGGCTGGTGGGCCCCG	0.622													32	61					6.90743e-12	7.61776e-12	1	0	T	27600461	T	T	27600461	3	4	191	1	0	0	0	0	1	0	0	0	18025	1348	47	4	52	4	ZNF513	2	27600461	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	20582303	27600461	215598912	33	35024											
C2orf56	55471	broad.mit.edu	37	chr2	37459318	37459318	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagaaaacccggtgacgcCgatgctgcggcatcttatgt	9	9	12	11	4	1	2	0	1	1	1	1	3	1	2	2	2	4	3	2	2	3	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:37459318C>G	uc002rqa.3	+	2	200	c.125C>G	c.(124-126)CCG>CGG	p.P42R	CEBPZ_uc002rpz.2_5'Flank|C2orf56_uc010ynj.1_RNA|C2orf56_uc002rqc.3_Missense_Mutation_p.P42R|C2orf56_uc010ynk.1_Missense_Mutation_p.P42R|C2orf56_uc010ynl.1_Missense_Mutation_p.P42R	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	42					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				CCGGTGACGCCGATGCTGCGG	0.478													6	111					0	0	0	0	G	37459318	G	G	37459318	3	3	191	1	0	0	0	0	1	0	0	0	2187	652	23	3	131	3	C2orf56	2	37459318	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	9858857	37459318	205740055	34	35025											
THADA	63892	broad.mit.edu	37	chr2	43808911	43808911	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accttggtaaaaatactcagCaatccacacatattttgcca	15	11	4	11	0	1	0	1	0	0	0	2	0	2	0	3	1	3	2	3	1	6	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:43808911C>T	uc002rsw.3	-	8	1042	c.690G>A	c.(688-690)TTG>TTA	p.L230L	THADA_uc002rsx.3_Silent_p.L230L|THADA_uc002rsy.3_RNA|THADA_uc002rsz.2_5'UTR|THADA_uc002rta.2_5'UTR|THADA_uc002rtb.1_Silent_p.L230L|THADA_uc002rtc.3_Silent_p.L230L|THADA_uc002rtd.2_Silent_p.L230L	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	230							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AAATACTCAGCAATCCACACA	0.328													8	72					0	0	0	0	T	43808911	T	T	43808911	2	4	191	1	0	0	0	0	0	0	0	1	15906	709	25	4		4	THADA	2	43808911	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	6349593	43808911	199390462	35	35026											
TTC7A	57217	broad.mit.edu	37	chr2	47278982	47278983	+	Missense_Mutation	DNP	GC	TT	TT																															ctgaagcagggccccatgcaGctgtggaccacgctggaaca																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:47278982_47278983GC>TT	uc002rvo.2	+	18	2483_2484	c.2115_2116GC>TT	c.(2113-2118)CAGCTG>CATTTG	p.Q705H	TTC7A_uc002rvm.2_Missense_Mutation_p.Q671H|TTC7A_uc010fbb.2_Missense_Mutation_p.Q729H|TTC7A_uc010fbc.2_Missense_Mutation_p.Q351H|TTC7A_uc002rvp.2_Missense_Mutation_p.Q586H|TTC7A_uc002rvq.2_Missense_Mutation_p.Q445H|TTC7A_uc002rvr.2_Missense_Mutation_p.Q154H	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	705							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GCCCCATGCAGCTGTGGACCAC	0.658													18	15					0	0	0	0	TT	47278983	TT	TT	47278982	3	4	191	1	0	0	0	0	1	0	0	0	16780	962	34	4	2185	4	TTC7A	2	47278982	Missense_Mutation	DNP	GC	TCGA-CV-6441-01A-11D-1683-08	3470071	47278982	195920391	36	35027											
PTCD3	55037	broad.mit.edu	37	chr2	86361419	86361419	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctttcttgtttcaagatagTaaagaatatggtcatacttt	12	17	6	6	0	3	2	2	0	1	2	3	2	3	2	1	1	1	2	1	1	7	8			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:86361419T>G	uc002sqw.2	+	20	1614	c.1548T>G	c.(1546-1548)AGT>AGG	p.S516R	PTCD3_uc002sqx.1_Missense_Mutation_p.S106R|SNORD94_uc010fgr.1_5'Flank	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	516	PPR 9.					mitochondrion	protein binding			ovary(1)	1						TTCAAGATAGTAAAGAATATG	0.408													12	26					0	0	0	0	G	86361419	G	G	86361419	3	3	191	1	0	0	0	0	1	0	0	0	12791	1635	57	5	1626	5	PTCD3	2	86361419	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	39082437	86361419	156837954	37	35028											
SLC5A7	60482	broad.mit.edu	37	chr2	108626801	108626801	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatgggctctggtacctcagTtctgaccttgtttacatcgt	6	16	9	10	1	3	1	1	1	2	0	4	1	3	1	2	2	2	4	2	2	3	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:108626801T>C	uc002tdv.2	+	9	1503	c.1227T>C	c.(1225-1227)AGT>AGC	p.S409S	SLC5A7_uc010ywm.1_Silent_p.S162S|SLC5A7_uc010fjj.2_Silent_p.S409S|SLC5A7_uc010ywn.1_Silent_p.S296S	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	409	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GGTACCTCAGTTCTGACCTTG	0.483													28	40					0	0	0	0	C	108626801	C	C	108626801	2	2	191	1	0	0	0	0	0	0	0	1	14734	1722	60	5		5	SLC5A7	2	108626801	Silent	SNP	T	TCGA-CV-6441-01A-11D-1683-08	22265382	108626801	134572572	38	35029											
MARCO	8685	broad.mit.edu	37	chr2	119727757	119727757	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatgacactctggcggctgaGgacagcccgtccttctcctt	7	10	10	14	2	2	2	0	2	2	0	4	3	3	3	3	3	1	1	3	3	1	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:119727757G>C	uc002tln.1	+	3	399	c.267G>C	c.(265-267)GAG>GAC	p.E89D	MARCO_uc010yyf.1_Missense_Mutation_p.E11D	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	89	Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TGGCGGCTGAGGACAGCCCGT	0.607													22	32					0	0	0	0	C	119727757	C	C	119727757	3	2	191	1	0	0	0	0	1	0	0	0	9364	991	35	4	277	4	MARCO	2	119727757	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	11100956	119727757	123471616	39	35030											
GLI2	2736	broad.mit.edu	37	chr2	121732650	121732650	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgccactgggaagactgcAccaaggagtacgacacccag	13	4	11	13	1	0	1	0	0	0	1	0	4	0	3	3	2	3	2	3	2	3	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:121732650A>G	uc010flp.2	+	8	1363	c.1333A>G	c.(1333-1335)ACC>GCC	p.T445A	GLI2_uc002tmq.1_Missense_Mutation_p.T117A|GLI2_uc002tmr.1_Missense_Mutation_p.T100A|GLI2_uc002tmt.3_Missense_Mutation_p.T117A|GLI2_uc002tmu.3_Missense_Mutation_p.T100A|GLI2_uc010flo.1_Missense_Mutation_p.T303A|GLI2_uc002tmw.1_Missense_Mutation_p.T428A	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	445	C2H2-type 1.				axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GGAAGACTGCACCAAGGAGTA	0.597													9	50					0	0	0	0	G	121732650	G	G	121732650	3	3	191	1	0	0	0	0	1	0	0	0	6475	159	6	5	1363	5	GLI2	2	121732650	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	2004893	121732650	121466723	40	35031											
LRP1B	53353	broad.mit.edu	37	chr2	141598641	141598641	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacacccaatccactgctaGccctctgatactctgaatat	11	11	5	14	0	2	3	0	3	2	0	3	3	3	3	3	0	3	1	3	0	5	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:141598641G>A	uc002tvj.1	-	30	5932	c.4960C>T	c.(4960-4962)CTA>TTA	p.L1654L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1654	Extracellular (Potential).|LDL-receptor class B 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCACTGCTAGCCCTCTGATA	0.368										TSP Lung(27;0.18)			27	45					0	0	0	0	A	141598641	A	A	141598641	2	1	191	1	0	0	0	0	0	0	0	1	9005	962	34	4		4	LRP1B	2	141598641	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	19865991	141598641	101600732	41	35032											
GALNT5	11227	broad.mit.edu	37	chr2	158157196	158157196	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattcttccaggtgtggatGtgtggtggtgaaattgagat	10	14	14	3	0	1	2	0	2	1	1	2	4	2	3	1	4	0	0	1	4	2	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:158157196G>A	uc002tzg.2	+	7	2379	c.2124G>A	c.(2122-2124)ATG>ATA	p.M708I	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	708	Catalytic subdomain B.|Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						AGGTGTGGATGTGTGGTGGTG	0.428													9	65					0	0	0	0	A	158157196	A	A	158157196	3	1	191	1	0	0	0	0	1	0	0	0	6251	1377	48	4	2150	4	GALNT5	2	158157196	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	16558555	158157196	85042177	42	35033											
BAZ2B	29994	broad.mit.edu	37	chr2	160206345	160206345	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtcaccaaagaagcagtTgacatatcggcatgagtaag	15	7	12	7	1	1	3	1	2	0	1	2	4	1	4	1	2	1	4	1	2	4	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:160206345T>C	uc002uao.2	-	28	5089	c.4737A>G	c.(4735-4737)TCA>TCG	p.S1579S	BAZ2B_uc002uap.2_Silent_p.S1543S	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1579					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AAGAAGCAGTTGACATATCGG	0.453													46	75					0	0	0	0	C	160206345	C	C	160206345	2	2	191	1	0	0	0	0	0	0	0	1	1334	1799	63	5		5	BAZ2B	2	160206345	Silent	SNP	T	TCGA-CV-6441-01A-11D-1683-08	2049149	160206345	82993028	43	35034											
CDCA7	83879	broad.mit.edu	37	chr2	174229611	174229611	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgtcctcttaccaggtcaaGgtcccggatcctcgggtccc	5	10	10	16	3	2	0	1	0	1	0	8	1	6	1	5	4	1	0	5	4	2	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:174229611G>T	uc002uid.1	+	5	682	c.551G>T	c.(550-552)AGG>ATG	p.R184M	CDCA7_uc002uic.1_Missense_Mutation_p.R263M|CDCA7_uc010zej.1_Missense_Mutation_p.R219M|CDCA7_uc010zek.1_Missense_Mutation_p.R142M	NM_145810	NP_665809	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7 isoform 2	184	Arg-rich.				regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.116)			ACCAGGTCAAGGTCCCGGATC	0.547													10	42					1.76689e-08	1.89484e-08	1	0	T	174229611	T	T	174229611	3	4	191	1	0	0	0	0	1	0	0	0	3105	1000	35	4	810	4	CDCA7	2	174229611	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	14023266	174229611	68969762	44	35035											
TTN	7273	broad.mit.edu	37	chr2	179430407	179430407	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttcctttgggctgcatttCaacaacgtaccccaggactc	9	11	8	13	1	1	0	1	0	0	0	3	1	2	1	3	2	4	4	3	2	3	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179430407C>T	uc010zfg.1	-	275	72972	c.72748G>A	c.(72748-72750)GAA>AAA	p.E24250K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E17945K|TTN_uc010zfi.1_Missense_Mutation_p.E17878K|TTN_uc010zfj.1_Missense_Mutation_p.E17753K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25177							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTGCATTTCAACAACGTAC	0.453													21	131					0	0	0	0	T	179430407	T	T	179430407	3	4	191	1	0	0	0	0	1	0	0	0	16803	835	29	2	27675	2	TTN	2	179430407	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	5200796	179430407	63768966	45	35036											
TTN	7273	broad.mit.edu	37	chr2	179458509	179458510	+	Frame_Shift_Ins	INS	-	T	T																															tgattttactgcctccatcaINStctaaaggaggcttccaaga																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179458509_179458510insT	uc010zfg.1	-	247	51037_51038	c.50813_50814insA	c.(50812-50814)GATfs	p.D16938fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Ins_p.D10633fs|TTN_uc010zfi.1_Frame_Shift_Ins_p.D10566fs|TTN_uc010zfj.1_Frame_Shift_Ins_p.D10441fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17865							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCCTCCATCATCTAAAGGAGG	0.416													---	---	---								T	179458510	T	T	179458509	7	5	191	1	0	1	1	0	0	0	0	0	16803	214	8	0	49721	0	TTN	2	179458509	Frame_Shift_Ins	INS	-	TCGA-CV-6441-01A-11D-1683-08	28102	179458509	63740864	46	35037											
TTN	7273	broad.mit.edu	37	chr2	179482556	179482556	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggctgcacttggttttccaActccaattcgattttgggct	6	16	9	10	1	0	0	0	0	0	0	3	1	2	0	2	3	2	4	2	3	2	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179482556A>T	uc010zfg.1	-	202	40042	c.39818T>A	c.(39817-39819)GTT>GAT	p.V13273D	TTN_uc010zfh.1_Missense_Mutation_p.V6968D|TTN_uc010zfi.1_Missense_Mutation_p.V6901D|TTN_uc010zfj.1_Missense_Mutation_p.V6776D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14200							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTTTTCCAACTCCAATTCG	0.443													45	75					0	0	0	0	T	179482556	T	T	179482556	3	4	191	1	0	0	0	0	1	0	0	0	16803	43	2	5	60611	5	TTN	2	179482556	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	24047	179482556	63716817	47	35038											
TTN	7273	broad.mit.edu	37	chr2	179616191	179616192	+	Frame_Shift_Ins	INS	-	T	T																															cccttttgttccacatcttgINSttttttgttaaagggagagc																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:179616191_179616192insT	uc002unb.2	-	46	11159_11160	c.10935_10936insA	c.(10933-10938)AAACAAfs	p.K3645fs	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	9490_Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCACATCTTGTTTTTTGTTAA	0.371													---	---	---								T	179616192	T	T	179616191	7	5	191	1	0	1	1	0	0	0	0	0	16803	1386	48	0	99361	0	TTN	2	179616191	Frame_Shift_Ins	INS	-	TCGA-CV-6441-01A-11D-1683-08	133635	179616191	63583182	48	35039											
ZNF385B	151126	broad.mit.edu	37	chr2	180348156	180348156	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttgtagtgggcctcggcCtggctctacaaaggagaaca	9	9	12	11	1	1	1	0	0	1	1	2	2	1	1	3	4	2	2	3	4	4	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:180348156C>A	uc002unn.3	-	6	1117	c.513G>T	c.(511-513)CAG>CAT	p.Q171H	ZNF385B_uc002unj.2_Missense_Mutation_p.Q69H|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Missense_Mutation_p.Q68H|ZNF385B_uc002unm.2_Missense_Mutation_p.Q95H	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	171	Matrin-type 2.					nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GGGCCTCGGCCTGGCTCTACA	0.428													30	34					2.80507e-11	3.05027e-11	1	0	A	180348156	A	A	180348156	3	1	191	1	0	0	0	0	1	0	0	0	17944	680	24	4	922	4	ZNF385B	2	180348156	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	731965	180348156	62851217	49	35040											
STAT1	6772	broad.mit.edu	37	chr2	191872313	191872313	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaatctctgggcgttttcCagaattttcctttcttcctt	6	20	5	10	1	2	1	0	0	2	1	6	1	5	1	3	1	0	1	3	1	3	8			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:191872313C>A	uc002usj.2	-	5	736	c.348G>T	c.(346-348)CTG>CTT	p.L116L	STAT1_uc010fse.1_Silent_p.L116L|STAT1_uc002usk.2_Silent_p.L116L|STAT1_uc002usl.2_Silent_p.L118L|STAT1_uc010fsf.1_5'UTR	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	116					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GGGCGTTTTCCAGAATTTTCC	0.328													38	44					2.19358e-23	2.48979e-23	1	0	A	191872313	A	A	191872313	2	1	191	1	0	0	0	0	0	0	0	1	15330	581	21	4		4	STAT1	2	191872313	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	11524157	191872313	51327060	50	35041											
RAPH1	65059	broad.mit.edu	37	chr2	204306102	204306102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggataaagggggcacaagtGaagtgtagggccgattcata	13	7	16	5	1	1	1	1	1	0	0	1	3	1	2	1	4	0	2	1	4	6	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:204306102G>A	uc002vad.2	-	14	2036	c.1811C>T	c.(1810-1812)TCA>TTA	p.S604L		NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	604					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						GGGCACAAGTGAAGTGTAGGG	0.378													4	17					0	0	0	0	A	204306102	A	A	204306102	3	1	191	1	0	0	0	0	1	0	0	0	13115	1294	45	2	1945	2	RAPH1	2	204306102	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	12433789	204306102	38893271	51	35042											
SPEG	10290	broad.mit.edu	37	chr2	220309817	220309817	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggtcagaggatagcctttCcgtggccagtgacctgtacg	7	9	15	10	2	1	2	1	1	0	1	2	3	2	3	4	4	2	1	4	4	2	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:220309817C>T	uc010fwg.2	+	3	749	c.749C>T	c.(748-750)TCC>TTC	p.S250F	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Intron|SPEG_uc002vln.1_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	250					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GATAGCCTTTCCGTGGCCAGT	0.652													4	8					0	0	0	0	T	220309817	T	T	220309817	3	4	191	1	0	0	0	0	1	0	0	0	15102	855	30	2	759	2	SPEG	2	220309817	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	16003715	220309817	22889556	52	35043											
KIAA1486	57624	broad.mit.edu	37	chr2	226446903	226446903	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaacattctcagagacttcaGgaaggaggacgatgaccaga	15	6	12	8	1	2	3	2	1	1	2	3	9	2	6	1	3	1	0	1	3	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:226446903G>A	uc002voe.2	+	4	945	c.770G>A	c.(769-771)AGG>AAG	p.R257K	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.R27K	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	257										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		AGAGACTTCAGGAAGGAGGAC	0.577													50	69					0	0	0	0	A	226446903	A	A	226446903	3	1	191	1	0	0	0	0	1	0	0	0	8276	1000	35	4	780	4	KIAA1486	2	226446903	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	6137086	226446903	16752470	53	35044											
COL4A3	1285	broad.mit.edu	37	chr2	228131135	228131135	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgctgtatttttataggtGacatcgtttttcgcaagggt	7	17	12	5	2	0	1	0	1	0	0	2	1	0	1	0	3	1	4	0	3	4	7			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:228131135G>A	uc002vom.1	+	22	1480	c.1318G>A	c.(1318-1320)GAC>AAC	p.D440N	COL4A3_uc002von.1_Missense_Mutation_p.D440N|COL4A3_uc002voo.1_Missense_Mutation_p.D440N|COL4A3_uc002vop.1_Missense_Mutation_p.D440N|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	440	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TTTTATAGGTGACATCGTTTT	0.393													3	33					0	0	0	0	A	228131135	A	A	228131135	3	1	191	1	0	0	0	0	1	0	0	0	3706	1290	45	2	1404	2	COL4A3	2	228131135	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	1684232	228131135	15068238	54	35045											
C2orf83	56918	broad.mit.edu	37	chr2	228476153	228476165	+	Frame_Shift_Del	DEL	TCTTGTGGCTTCT	-	-																															aatggctccagagcaccgaaTcttgtggcttcttgttctct																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:228476153_228476165delTCTTGTGGCTTCT	uc002vph.2	-	3	633_645	c.398_410delAGAAGCCACAAGA	c.(397-411)AAGAAGCCACAAGATfs	p.K133fs	C2orf83_uc010zlu.1_3'UTR	NM_020161	NP_064546	Q53S99	CB083_HUMAN	hypothetical protein LOC56918 isoform 1	133_137						membrane	folic acid binding|reduced folate carrier activity				0						GAGCACCGAATCTTGTGGCTTCTTGTTCTCTGT	0.493													---	---	---								-	228476165	-	-	228476153	7	5	191	1	0	1	0	1	0	0	0	0	2208	1435	50	0	46	0	C2orf83	2	228476153	Frame_Shift_Del	DEL	TCTTGTGGCTTCT	TCGA-CV-6441-01A-11D-1683-08	345018	228476153	14723220	55	35046											
EIF4E2	9470	broad.mit.edu	37	chr2	233431923	233431923	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactcacaccgacagcatcAagtacgtgttggggggttat	12	9	11	9	2	2	0	2	0	0	0	2	1	2	0	1	3	3	4	1	3	4	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:233431923A>G	uc002vta.2	+	6	742	c.664A>G	c.(664-666)AAA>GAA	p.K222E	EIF4E2_uc002vtb.1_Missense_Mutation_p.K222E|EIF4E2_uc010zmi.1_Missense_Mutation_p.K177E	NM_004846	NP_004837	O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E	222	7-methylguanosine-containing mRNA cap binding (By similarity).				regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CGACAGCATCAAGTACGTGTT	0.507													3	103					0	0	0	0	G	233431923	G	G	233431923	3	3	191	1	0	0	0	0	1	0	0	0	5054	144	5	5	686	5	EIF4E2	2	233431923	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	4955770	233431923	9767450	56	35047											
UGT1A6	54578	broad.mit.edu	37	chr2	234602466	234602466	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccggtcatgcccaacatggtCttcattggaggtatcaactg	9	11	10	11	1	4	0	3	0	1	0	4	1	4	1	2	4	3	1	2	4	3	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:234602466C>T	uc002vuv.3	+	1	955	c.816C>T	c.(814-816)GTC>GTT	p.V272V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Silent_p.V5V|UGT1A6_uc010zmy.1_Silent_p.V272V	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	272					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		CCAACATGGTCTTCATTGGAG	0.438													243	375					0	0	0	0	T	234602466	T	T	234602466	2	4	191	1	0	0	0	0	0	0	0	1	17017	900	32	2		2	UGT1A6	2	234602466	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	1170543	234602466	8596907	57	35048											
STK25	10494	broad.mit.edu	37	chr2	242435884	242435884	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggactcctcggccaggctGaaggcgttctccagctcctc	6	8	11	16	2	1	1	0	1	1	0	6	2	3	2	4	4	1	3	4	4	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr2:242435884G>C	uc002wbm.2	-	10	1441	c.1170C>G	c.(1168-1170)TTC>TTG	p.F390L	STK25_uc002wbk.2_Missense_Mutation_p.F209L|STK25_uc002wbl.2_3'UTR|STK25_uc002wbn.2_Missense_Mutation_p.F390L|STK25_uc002wbo.2_Missense_Mutation_p.F313L|STK25_uc010zos.1_Missense_Mutation_p.F296L|STK25_uc010zot.1_Missense_Mutation_p.F316L|STK25_uc002wbp.2_Missense_Mutation_p.F390L|STK25_uc010fzo.2_Missense_Mutation_p.F313L|STK25_uc010zou.1_Missense_Mutation_p.F296L|STK25_uc010zov.1_Missense_Mutation_p.F296L	NM_006374	NP_006365	O00506	STK25_HUMAN	serine/threonine kinase 25	390					response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		CGGCCAGGCTGAAGGCGTTCT	0.657													13	59					0	0	0	0	C	242435884	C	C	242435884	3	2	191	1	0	0	0	0	1	0	0	0	15360	1281	45	2	118	2	STK25	2	242435884	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	7833418	242435884	763489	58	35049											
EPHA3	2042	broad.mit.edu	37	chr3	89498433	89498433	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatagcctaccgcaagttcaCgtcagccagcgatgtatgga	11	9	10	11	3	2	0	2	0	0	0	2	2	2	1	3	1	4	3	3	1	5	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:89498433C>G	uc003dqy.2	+	14	2630	c.2405C>G	c.(2404-2406)ACG>AGG	p.T802R	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	802	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CGCAAGTTCACGTCAGCCAGC	0.438										TSP Lung(6;0.00050)			50	65					0	0	0	0	G	89498433	G	G	89498433	3	3	191	1	0	0	0	0	1	0	0	0	5192	536	19	3	2485	3	EPHA3	3	89498433	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08		89498433	108523997	59	35050											
OR5H14	403273	broad.mit.edu	37	chr3	97868318	97868318	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatacccctgttcctggCattcttggtaatatatctca	11	14	6	10	0	2	0	1	0	2	0	4	1	3	0	3	2	1	3	3	2	6	7			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:97868318C>A	uc003dsg.1	+	1	89	c.89C>A	c.(88-90)GCA>GAA	p.A30E		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTGTTCCTGGCATTCTTGGTA	0.418													80	153					2.36867e-37	2.71829e-37	1	0	A	97868318	A	A	97868318	3	1	191	1	0	0	0	0	1	0	0	0	11214	710	25	4	91	4	OR5H14	3	97868318	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	8369885	97868318	100154112	60	35051											
CCDC80	151887	broad.mit.edu	37	chr3	112358039	112358039	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccacctgcagcgtcttcttCagcagcaccatgccaaactt	9	10	6	16	1	3	0	1	0	2	0	4	0	4	0	4	0	6	3	4	0	1	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:112358039C>T	uc003dzf.2	-	2	932	c.714G>A	c.(712-714)CTG>CTA	p.L238L	CCDC80_uc011bhv.1_Silent_p.L238L|CCDC80_uc003dzg.2_Silent_p.L238L|CCDC80_uc003dzh.1_Silent_p.L238L	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	238										ovary(2)	2						GCGTCTTCTTCAGCAGCACCA	0.582													20	108					0	0	0	0	T	112358039	T	T	112358039	2	4	191	1	0	0	0	0	0	0	0	1	2867	813	29	2		2	CCDC80	3	112358039	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	14489721	112358039	85664391	61	35052											
DRD3	1814	broad.mit.edu	37	chr3	113850024	113850024	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtggcactccccgaggtTgcaggggccccagcttcaaa	9	6	13	13	1	1	0	1	0	0	0	2	2	2	0	4	4	2	4	4	4	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:113850024T>G	uc003ebd.2	-	7	1370	c.947A>C	c.(946-948)CAA>CCA	p.Q316P	DRD3_uc010hqn.1_Missense_Mutation_p.Q316P|DRD3_uc003ebb.1_Intron|DRD3_uc003ebc.1_Missense_Mutation_p.Q316P	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	316	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	TCCCCGAGGTTGCAGGGGCCC	0.443													21	94					0	0	0	0	G	113850024	G	G	113850024	3	3	191	1	0	0	0	0	1	0	0	0	4780	1812	63	5	263	5	DRD3	3	113850024	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	1491985	113850024	84172406	62	35053											
ZNF80	7634	broad.mit.edu	37	chr3	113955700	113955700	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctggcattcataaggcttCaccccagtgtgaatctgctg	8	12	9	12	0	3	1	2	1	1	0	4	1	4	1	3	2	1	3	3	2	2	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:113955700C>T	uc010hqo.2	-	1	726	c.222G>A	c.(220-222)GTG>GTA	p.V74V	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	74						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				CATAAGGCTTCACCCCAGTGT	0.498													8	23					0	0	0	0	T	113955700	T	T	113955700	2	4	191	1	0	0	0	0	0	0	0	1	18235	813	29	2		2	ZNF80	3	113955700	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	105676	113955700	84066730	63	35054											
STXBP5L	9515	broad.mit.edu	37	chr3	120941894	120941894	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggctgtcctatgacaaagCttgtagaagaccaagtttaa	13	11	10	7	0	0	3	0	1	0	2	1	3	1	3	2	1	1	4	2	1	6	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:120941894C>A	uc003eec.3	+	11	1141	c.1001C>A	c.(1000-1002)GCT>GAT	p.A334D	STXBP5L_uc011bji.1_Missense_Mutation_p.A334D	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	334	WD 6.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		TATGACAAAGCTTGTAGAAGA	0.368													33	59					1.26612e-14	1.41641e-14	1	0	A	120941894	A	A	120941894	3	1	191	1	0	0	0	0	1	0	0	0	15423	797	28	4	1039	4	STXBP5L	3	120941894	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	6986194	120941894	77080536	64	35055											
SGEF	26084	broad.mit.edu	37	chr3	153973168	153973168	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagaaagaggctggtttcCtatggaatgtgccaaggaga	12	9	15	5	0	0	3	0	0	0	3	1	6	1	4	2	5	1	2	2	5	4	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr3:153973168C>G	uc011bog.1	+	15	2733	c.2522C>G	c.(2521-2523)CCT>CGT	p.P841R	SGEF_uc011boh.1_3'UTR|SGEF_uc011boi.1_Missense_Mutation_p.P109R	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	841	SH3.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GGCTGGTTTCCTATGGAATGT	0.468													16	63					0	0	0	0	G	153973168	G	G	153973168	3	3	191	1	0	0	0	0	1	0	0	0	14270	681	24	4	2362	4	SGEF	3	153973168	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	33031274	153973168	44049262	65	35056											
LYAR	55646	broad.mit.edu	37	chr4	4270287	4270287	+	Frame_Shift_Del	DEL	A	-	-																															agctttttgatggttatttcAttgtctggggcctgtttcag																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:4270287delA	uc011bvy.1	-	9	1118	c.975delT	c.(973-975)AATfs	p.N325fs	LYAR_uc011bvx.1_Frame_Shift_Del_p.N208fs|LYAR_uc003ght.2_Frame_Shift_Del_p.N325fs	NM_001145725	NP_001139197	Q9NX58	LYAR_HUMAN	Ly1 antibody reactive homolog	325	Lys-rich.					nucleolus	metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGGTTATTTCATTGTCTGGGG	0.333													---	---	---								-	4270287	-	-	4270287	7	5	191	1	0	1	0	1	0	0	0	0	9154	214	8	0	172	0	LYAR	4	4270287	Frame_Shift_Del	DEL	A	TCGA-CV-6441-01A-11D-1683-08		4270287	186883989	66	35057											
NCAPG	64151	broad.mit.edu	37	chr4	17829921	17829921	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgatgctgaaacattgcaGaaatgtcttattttatgcta	14	15	7	5	0	1	3	0	2	1	1	1	3	1	3	0	0	4	3	0	0	6	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:17829921G>C	uc003gpp.2	+	12	1850	c.1674G>C	c.(1672-1674)CAG>CAC	p.Q558H	NCAPG_uc011bxj.1_Missense_Mutation_p.Q67H	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	558					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		AAACATTGCAGAAATGTCTTA	0.348													17	32					0	0	0	0	C	17829921	C	C	17829921	3	2	191	1	0	0	0	0	1	0	0	0	10261	933	33	2	1720	2	NCAPG	4	17829921	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	13559634	17829921	173324355	67	35058											
SLIT2	9353	broad.mit.edu	37	chr4	20525414	20525414	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaacaagataaactgccttCgggtagatgcttttcaggat	12	11	9	9	1	1	2	1	0	0	2	2	3	1	3	2	2	4	2	2	2	5	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:20525414C>T	uc003gpr.1	+	13	1366	c.1162C>T	c.(1162-1164)CGG>TGG	p.R388W	SLIT2_uc003gps.1_Missense_Mutation_p.R388W	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	388	LRR 10.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AAACTGCCTTCGGGTAGATGC	0.408													23	78					0	0	0	0	T	20525414	T	T	20525414	3	4	191	1	0	0	0	0	1	0	0	0	14804	875	31	1	1212	1	SLIT2	4	20525414	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	2695493	20525414	170628862	68	35059											
KLF3	51274	broad.mit.edu	37	chr4	38696416	38696416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggaagagacctttacctgtgGaatccccggatactcaaagg	12	8	11	10	1	1	1	1	0	0	1	2	5	2	4	4	4	2	0	4	4	5	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:38696416G>A	uc003gth.3	+	5	1077	c.745G>A	c.(745-747)GAA>AAA	p.E249K		NM_016531	NP_057615	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	249	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						TTTACCTGTGGAATCCCCGGA	0.478													11	81					0	0	0	0	A	38696416	A	A	38696416	3	1	191	1	0	0	0	0	1	0	0	0	8386	1175	41	2	759	2	KLF3	4	38696416	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	18171002	38696416	152457860	69	35060											
EPHA5	2044	broad.mit.edu	37	chr4	66361186	66361187	+	Missense_Mutation	DNP	TG	AT	AT																															aagaggttgaagcttcctcaTgggtataactgtgaggtgga																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:66361186_66361187TG>AT	uc003hcy.2	-	4	1178_1179	c.985_986CA>AT	c.(985-987)CAT>ATT	p.H329I	EPHA5_uc003hcx.2_Missense_Mutation_p.H260I|EPHA5_uc003hcz.2_Missense_Mutation_p.H329I|EPHA5_uc011cah.1_Missense_Mutation_p.H329I|EPHA5_uc011cai.1_Missense_Mutation_p.H329I|EPHA5_uc003hda.2_Missense_Mutation_p.H329I	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	329	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AGCTTCCTCATGGGTATAACTG	0.465										TSP Lung(17;0.13)			39	74					0	0	0	0	AT	66361187	AT	AT	66361186	3	1	191	1	0	0	0	0	1	0	0	0	5194	1464	51	5	2187	5	EPHA5	4	66361186	Missense_Mutation	DNP	TG	TCGA-CV-6441-01A-11D-1683-08	27664770	66361186	124793090	70	35061											
TMPRSS11D	9407	broad.mit.edu	37	chr4	68703947	68703947	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagttattcagcatttgtcGtaaaacagactcaattctgc	13	13	7	8	1	3	2	2	0	1	2	4	2	3	2	0	0	3	3	0	0	4	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:68703947G>A	uc003hdq.2	-	5	483	c.418C>T	c.(418-420)CGA>TGA	p.R140*	LOC550112_uc003hdl.3_Intron|TMPRSS11D_uc011caj.1_Nonsense_Mutation_p.R23*	NM_004262	NP_004253	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	140	SEA.|Extracellular (Potential).				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AGCATTTGTCGTAAAACAGAC	0.333													19	31					0	0	0	0	A	68703947	A	A	68703947	4	1	191	1	0	0	0	0	0	1	0	0	16307	1153	40	1	862	1	TMPRSS11D	4	68703947	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	2342761	68703947	122450329	71	35062											
UGT2B7	7364	broad.mit.edu	37	chr4	69978401	69978401	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatcgtcacaaaatgttgtCtgttttgtttctggaagttt	8	20	8	5	1	3	0	1	0	2	0	4	1	3	1	0	1	0	4	0	1	4	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:69978401C>G	uc003heg.3	+	6	1583	c.1537C>G	c.(1537-1539)CTG>GTG	p.L513V	UGT2B7_uc010ihq.2_3'UTR	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	513					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						AAAATGTTGTCTGTTTTGTTT	0.413													37	46					0	0	0	0	G	69978401	G	G	69978401	3	3	191	1	0	0	0	0	1	0	0	0	17030	912	32	2	1559	2	UGT2B7	4	69978401	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	1274454	69978401	121175875	72	35063											
UGT2B28	54490	broad.mit.edu	37	chr4	70152479	70152479	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttttttcacaggaaatggagGaatttgtacagagctctggt	11	14	11	5	0	2	1	1	0	1	1	2	4	2	4	0	4	2	2	0	4	3	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:70152479G>C	uc003hej.2	+	3	882	c.880G>C	c.(880-882)GAA>CAA	p.E294Q	UGT2B28_uc010ihr.2_Missense_Mutation_p.E294Q	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	294					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	GGAAATGGAGGAATTTGTACA	0.383													57	104					0	0	0	0	C	70152479	C	C	70152479	3	2	191	1	0	0	0	0	1	0	0	0	17028	1175	41	2	890	2	UGT2B28	4	70152479	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	174078	70152479	121001797	73	35064											
RG9MTD2	93587	broad.mit.edu	37	chr4	100475021	100475021	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcagtatattaggtgaaTctgacgtaaggtaaatcagg	13	12	10	6	1	3	2	2	2	1	0	3	2	3	2	1	3	0	3	1	3	7	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:100475021T>C	uc003huy.2	-	6	879	c.566A>G	c.(565-567)GAT>GGT	p.D189G	RG9MTD2_uc003huz.3_Missense_Mutation_p.D189G|RG9MTD2_uc003hva.3_Missense_Mutation_p.D189G	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	189							methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)		ATTAGGTGAATCTGACGTAAG	0.338													31	7					0	0	0	0	C	100475021	C	C	100475021	3	2	191	1	0	0	0	0	1	0	0	0	13337	1435	50	5	465	5	RG9MTD2	4	100475021	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	30322542	100475021	90679255	74	35065											
ANKRD50	57182	broad.mit.edu	37	chr4	125592804	125592804	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaataatgttctcccatttGaatcacactgatttactgaa	13	14	4	10	0	2	3	1	3	1	0	3	3	2	3	2	0	1	1	2	0	5	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:125592804G>C	uc003ifg.3	-	3	1894	c.1628C>G	c.(1627-1629)TCA>TGA	p.S543*	ANKRD50_uc011cgo.1_Nonsense_Mutation_p.S364*|ANKRD50_uc010inw.2_Nonsense_Mutation_p.S543*	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	543										central_nervous_system(1)	1						TCTCCCATTTGAATCACACTG	0.398													42	11					0	0	0	0	C	125592804	C	C	125592804	4	2	191	1	0	0	0	0	0	1	0	0	677	1294	45	2	2665	2	ANKRD50	4	125592804	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	25117783	125592804	65561472	75	35066											
SNX25	83891	broad.mit.edu	37	chr4	186188282	186188282	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagctcattaacagcaactCtgatgtggagttcttgaagc	12	11	9	9	0	3	2	1	2	2	0	3	3	3	3	0	1	5	3	0	1	4	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:186188282C>T	uc003ixh.2	+	5	761	c.572C>T	c.(571-573)TCT>TTT	p.S191F		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	191					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		AACAGCAACTCTGATGTGGAG	0.438													15	51					0	0	0	0	T	186188282	T	T	186188282	3	4	191	1	0	0	0	0	1	0	0	0	14960	913	32	2	586	2	SNX25	4	186188282	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	60595478	186188282	4965994	76	35067											
FAT1	2195	broad.mit.edu	37	chr4	187627830	187627830	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgacaccgtcattaccaatGaaccaacaggtgcatcttct	12	9	6	14	2	3	1	1	1	2	0	3	2	3	1	4	1	4	1	4	1	4	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr4:187627830G>C	uc003izf.2	-	2	3340	c.3152C>G	c.(3151-3153)TCA>TGA	p.S1051*	FAT1_uc010iso.1_Nonsense_Mutation_p.S1051*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1051	Extracellular (Potential).|Cadherin 9.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CATTACCAATGAACCAACAGG	0.483										HNSCC(5;0.00058)			51	26					0	0	0	0	C	187627830	C	C	187627830	4	2	191	1	0	0	0	0	0	1	0	0	5721	1294	45	2	10718	2	FAT1	4	187627830	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	1439548	187627830	3526446	77	35068											
LPCAT1	79888	broad.mit.edu	37	chr5	1489929	1489929	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttttcctgcgagaatcctGgtctgaccgggacacgaaca	9	10	11	11	3	1	2	0	1	1	1	3	5	3	3	3	2	2	1	3	2	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:1489929G>A	uc003jcm.2	-	4	655	c.538C>T	c.(538-540)CAG>TAG	p.Q180*		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	180	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		CGAGAATCCTGGTCTGACCGG	0.557													20	479					0	0	0	0	A	1489929	A	A	1489929	4	1	191	1	0	0	0	0	0	1	0	0	8960	1357	47	4	1110	4	LPCAT1	5	1489929	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08		1489929	179425331	78	35069											
KIAA0947	23379	broad.mit.edu	37	chr5	5463028	5463028	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagttcaggggactctgtttCtgaatgttctagtaaaggaa	11	14	11	5	0	4	1	1	1	3	0	4	3	4	3	0	3	0	4	0	3	6	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:5463028C>G	uc003jdm.3	+	13	3803	c.3581C>G	c.(3580-3582)TCT>TGT	p.S1194C		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1194										ovary(1)|central_nervous_system(1)	2						GACTCTGTTTCTGAATGTTCT	0.378													6	41					0	0	0	0	G	5463028	G	G	5463028	3	3	191	1	0	0	0	0	1	0	0	0	8241	913	32	2	3631	2	KIAA0947	5	5463028	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	3973099	5463028	175452232	79	35070											
DNAH5	1767	broad.mit.edu	37	chr5	13901563	13901563	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgggaggctggtttcgaGccagaggaggatcgtatttc	8	10	16	7	3	0	1	0	0	0	1	3	6	0	4	1	5	1	3	1	5	1	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:13901563G>A	uc003jfd.2	-	14	1892	c.1850C>T	c.(1849-1851)GCT>GTT	p.A617V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	617	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTGGTTTCGAGCCAGAGGAGG	0.478									Kartagener_syndrome				18	79					0	0	0	0	A	13901563	A	A	13901563	3	1	191	1	0	0	0	0	1	0	0	0	4626	971	34	4	12288	4	DNAH5	5	13901563	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	8438535	13901563	167013697	80	35071											
CDH10	1008	broad.mit.edu	37	chr5	24535254	24535254	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgggttgtcattgacatCtgtcagcgtgatgttcacag	7	14	13	7	1	4	2	3	2	1	0	4	2	4	2	0	2	1	2	0	2	0	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:24535254C>T	uc003jgr.1	-	5	1113	c.781G>A	c.(781-783)GAT>AAT	p.D261N	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	261	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCATTGACATCTGTCAGCGTG	0.453										HNSCC(23;0.051)			8	135					0	0	0	0	T	24535254	T	T	24535254	3	4	191	1	0	0	0	0	1	0	0	0	3111	913	32	2	1617	2	CDH10	5	24535254	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	10633691	24535254	156380006	81	35072											
PDZD2	23037	broad.mit.edu	37	chr5	32037403	32037403	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccaaggggaacttggaaagtCccaaacagggcagcaataaa	17	4	11	9	0	0	0	0	0	0	0	1	2	1	2	2	4	3	2	2	4	7	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:32037403C>G	uc003jhl.2	+	7	1862	c.1474C>G	c.(1474-1476)CCC>GCC	p.P492A	PDZD2_uc003jhm.2_Missense_Mutation_p.P492A|PDZD2_uc011cnx.1_Missense_Mutation_p.P318A	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	492					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CTTGGAAAGTCCCAAACAGGG	0.522													6	78					0	0	0	0	G	32037403	G	G	32037403	3	3	191	1	0	0	0	0	1	0	0	0	11755	855	30	2	1496	2	PDZD2	5	32037403	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	7502149	32037403	148877857	82	35073											
RANBP3L	202151	broad.mit.edu	37	chr5	36251436	36251436	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgatccatttttagtgacttGgatgaaatcatcctcattct	10	17	6	8	0	3	3	2	3	1	0	5	4	5	4	2	1	0	0	2	1	2	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:36251436G>T	uc003jkh.2	-	13	1826	c.1333C>A	c.(1333-1335)CAA>AAA	p.Q445K	RANBP3L_uc011cow.1_Missense_Mutation_p.Q470K	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	445					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TTAGTGACTTGGATGAAATCA	0.353													4	106					8.12818e-05	8.42622e-05	1	0	T	36251436	T	T	36251436	3	4	191	1	0	0	0	0	1	0	0	0	13095	1357	47	4	72	4	RANBP3L	5	36251436	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	4214033	36251436	144663824	83	35074											
NUP155	9631	broad.mit.edu	37	chr5	37371159	37371159	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatccaagaagttagcttaGatccgccgcctagggcgcgc	10	7	12	12	4	0	3	0	0	0	3	2	3	2	3	4	1	1	2	4	1	5	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:37371159G>C	uc003jku.1	-	1	39	c.-79C>G	c.(-81--77)ATCTA>ATGTA		NUP155_uc003jkt.1_5'Flank|NUP155_uc010iuz.1_Translation_Start_Site	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1						carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTTAGCTTAGATCCGCCGCC	0.557													3	27					0	0	0	0	C	37371159	C	C	37371159	1	2	191	1	0	0	0	0	0	0	0	0	10810	957	33	2		2	NUP155	5	37371159	Translation_Start_Site	SNP	G	TCGA-CV-6441-01A-11D-1683-08	1119723	37371159	143544101	84	35075											
C5orf28	64417	broad.mit.edu	37	chr5	43453838	43453838	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatccagctaaaatgatttcTccaaagtcagtcttcttctt	12	15	4	10	0	5	1	1	1	4	0	7	1	6	1	2	0	1	1	2	0	4	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:43453838T>A	uc003jny.2	-	2	377	c.234A>T	c.(232-234)GGA>GGT	p.G78G	C5orf28_uc003jnv.3_Silent_p.G78G|C5orf28_uc003jnx.2_Silent_p.G78G	NM_022483	NP_071928	Q0VDI3	CE028_HUMAN	hypothetical protein LOC64417	78	Helical; (Potential).					integral to membrane					0	Lung NSC(6;2.07e-05)					AAATGATTTCTCCAAAGTCAG	0.393													33	128					0	0	0	0	A	43453838	A	A	43453838	2	1	191	1	0	0	0	0	0	0	0	1	2299	1538	54	5		5	C5orf28	5	43453838	Silent	SNP	T	TCGA-CV-6441-01A-11D-1683-08	6082679	43453838	137461422	85	35076											
CMYA5	202333	broad.mit.edu	37	chr5	79095241	79095241	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgatgttcatgtgactgaGcgtccagccagagtgggcat	9	10	14	8	1	1	4	1	3	0	1	2	4	2	4	2	1	2	2	2	1	0	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:79095241G>A	uc003kgc.2	+	13	12084	c.12012G>A	c.(12010-12012)GAG>GAA	p.E4004E		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	4004	B30.2/SPRY.					perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ATGTGACTGAGCGTCCAGCCA	0.443													7	45					0	0	0	0	A	79095241	A	A	79095241	2	1	191	1	0	0	0	0	0	0	0	1	3605	962	34	4		4	CMYA5	5	79095241	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	35641403	79095241	101820019	86	35077											
HAPLN1	1404	broad.mit.edu	37	chr5	82940335	82940335	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagccatcactgagccagcCggcattgcaccagtccagcc	10	5	10	16	1	1	2	1	1	0	1	2	2	2	2	6	1	5	2	6	1	0	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:82940335C>A	uc003kim.2	-	3	693	c.622G>T	c.(622-624)GGC>TGC	p.G208C	HAPLN1_uc003kin.2_Missense_Mutation_p.G208C	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	208	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CTGAGCCAGCCGGCATTGCAC	0.622													46	11					1.41504e-22	1.60028e-22	1	0	A	82940335	A	A	82940335	3	1	191	1	0	0	0	0	1	0	0	0	6993	652	23	3	450	3	HAPLN1	5	82940335	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	3845094	82940335	97974925	87	35078											
LOX	4015	broad.mit.edu	37	chr5	121411146	121411146	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatcttggtcggctgggtaaGaaatctgatgtcccttggtt	7	15	12	7	1	2	2	0	1	2	1	4	2	3	2	1	4	0	3	1	4	3	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:121411146G>A	uc003ksu.2	-	3	1206	c.831C>T	c.(829-831)TTC>TTT	p.F277F	LOX_uc010jcp.2_5'Flank|LOX_uc010jcq.2_5'UTR|LOX_uc011cwk.1_Silent_p.F47F|LOX_uc010jcr.2_5'UTR	NM_002317	NP_002308	P28300	LYOX_HUMAN	lysyl oxidase preproprotein	277	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			lung(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		GGCTGGGTAAGAAATCTGATG	0.453													13	75					0	0	0	0	A	121411146	A	A	121411146	2	1	191	1	0	0	0	0	0	0	0	1	8948	933	33	2		2	LOX	5	121411146	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	38470811	121411146	59504114	88	35079											
RAPGEF6	51735	broad.mit.edu	37	chr5	130897699	130897699	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttctgaaggctctaatacaAgacaatcacatcctcttttt	12	15	4	10	0	4	2	1	1	3	1	5	2	5	2	1	1	1	1	1	1	5	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:130897699A>T	uc003kvn.1	-	5	529	c.323T>A	c.(322-324)CTT>CAT	p.L108H	RAPGEF6_uc003kvp.1_Missense_Mutation_p.L158H|RAPGEF6_uc003kvo.1_Missense_Mutation_p.L108H|RAPGEF6_uc010jdi.1_Missense_Mutation_p.L108H|RAPGEF6_uc010jdj.1_Missense_Mutation_p.L108H|RAPGEF6_uc003kvr.2_Missense_Mutation_p.L108H|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.L108H	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	108					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CTCTAATACAAGACAATCACA	0.274													63	12					0	0	0	0	T	130897699	T	T	130897699	3	4	191	1	0	0	0	0	1	0	0	0	13113	72	3	5	5064	5	RAPGEF6	5	130897699	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	9486553	130897699	50017561	89	35080											
PCDHA8	56140	broad.mit.edu	37	chr5	140222091	140222091	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgatgccccatgtccccttCaagctggtgtccaccttcaa	7	11	7	16	0	2	1	2	1	0	0	4	1	4	1	6	1	2	1	6	1	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:140222091C>G	uc003lhs.2	+	1	1185	c.1185C>G	c.(1183-1185)TTC>TTG	p.F395L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.F395L	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	395	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTCCCCTTCAAGCTGGTGT	0.577													43	192					0	0	0	0	G	140222091	G	G	140222091	3	3	191	1	0	0	0	0	1	0	0	0	11584	825	29	2	1187	2	PCDHA8	5	140222091	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	9324392	140222091	40693169	90	35081											
HDAC3	8841	broad.mit.edu	37	chr5	141009429	141009429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcacctcctcactcacctCaaacttcttggcatggtgca	9	11	5	16	0	5	0	4	0	1	0	6	0	6	0	3	2	2	2	3	2	1	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:141009429C>T	uc003llf.2	-	5	484	c.418G>A	c.(418-420)GAG>AAG	p.E140K	HDAC3_uc003lle.1_Missense_Mutation_p.E83K|HDAC3_uc010jgd.1_Missense_Mutation_p.E65K|HDAC3_uc010jge.1_Intron	NM_003883	NP_003874	O15379	HDAC3_HUMAN	histone deacetylase 3	140	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	TCACTCACCTCAAACTTCTTG	0.517													9	50					0	0	0	0	T	141009429	T	T	141009429	3	4	191	1	0	0	0	0	1	0	0	0	7047	835	29	2	912	2	HDAC3	5	141009429	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	787338	141009429	39905831	91	35082											
C5orf54	63920	broad.mit.edu	37	chr5	159821613	159821613	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgatgaaatttattaccctCaccacagtaaacagagcatc	15	11	5	10	0	1	3	1	2	0	1	2	3	1	3	2	0	3	2	2	0	5	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:159821613C>G	uc003lye.1	-	2	1349	c.885G>C	c.(883-885)GTG>GTC	p.V295V	C5orf54_uc003lyf.1_Silent_p.V295V	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	295										pancreas(1)	1						ttattaccctcaccacagtaa	0													28	92					0	0	0	0	G	159821613	G	G	159821613	2	3	191	1	0	0	0	0	0	0	0	1	2320	813	29	2		2	C5orf54	5	159821613	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	18812184	159821613	21093647	92	35083											
NSD1	64324	broad.mit.edu	37	chr5	176618931	176618931	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaagtatgaagttggagAtctcatctgggcaaaattca	14	11	10	6	0	3	3	2	2	2	1	4	4	3	3	0	2	0	3	0	2	5	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr5:176618931A>T	uc003mfr.3	+	3	1112	c.974A>T	c.(973-975)GAT>GTT	p.D325V	NSD1_uc003mft.3_Missense_Mutation_p.D56V|NSD1_uc003mfs.1_Intron|NSD1_uc011dfx.1_5'UTR|NSD1_uc003mfp.2_Missense_Mutation_p.D325V	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	325	PWWP 1.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GAAGTTGGAGATCTCATCTGG	0.388			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			41	16					0	0	0	0	T	176618931	T	T	176618931	3	4	191	1	0	0	0	0	1	0	0	0	10723	333	12	5	980	5	NSD1	5	176618931	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	16797318	176618931	4296329	93	35084											
C6orf195	154386	broad.mit.edu	37	chr6	2623874	2623874	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgccgacaaggccggacccGggaggggagaggagcctgta	9	3	19	10	3	0	1	0	0	0	1	0	6	0	4	4	6	2	1	4	6	2	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:2623874G>A	uc003mtw.2	-	3	1168	c.183C>T	c.(181-183)CCC>CCT	p.P61P		NM_152554	NP_689767	Q96MT4	CF195_HUMAN	hypothetical protein LOC154386	61											0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				GGCCGGACCCGGGAGGGGAGA	0.632													46	73					0	0	0	0	A	2623874	A	A	2623874	2	1	191	1	0	0	0	0	0	0	0	1	2360	1103	39	1		1	C6orf195	6	2623874	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08		2623874	168491193	94	35085											
PAK1IP1	55003	broad.mit.edu	37	chr6	10707670	10707670	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaaggacatgttcagttttGaaattccagagcatcatgtt	13	14	8	6	0	2	2	2	1	0	1	3	3	3	3	1	1	1	4	1	1	3	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:10707670G>C	uc003mzg.2	+	8	794	c.763G>C	c.(763-765)GAA>CAA	p.E255Q		NM_017906	NP_060376	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	255	WD 5.				negative regulation of signal transduction	nucleolus|plasma membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				GTTCAGTTTTGAAATTCCAGA	0.333													22	90					0	0	0	0	C	10707670	C	C	10707670	3	2	191	1	0	0	0	0	1	0	0	0	11454	1291	45	2	793	2	PAK1IP1	6	10707670	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	8083796	10707670	160407397	95	35086											
HIST1H1C	3006	broad.mit.edu	37	chr6	26056153	26056153	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgggctcttagccactttCttggttacagtggccgcggc	4	14	12	11	2	2	0	0	0	2	0	2	0	2	0	2	4	2	2	2	4	2	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:26056153C>G	uc003nfw.2	-	1	547	c.504G>C	c.(502-504)AAG>AAC	p.K168N		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	168					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						TAGCCACTTTCTTGGTTACAG	0.572													61	27					0	0	0	0	G	26056153	G	G	26056153	3	3	191	1	0	0	0	0	1	0	0	0	7163	912	32	2	141	2	HIST1H1C	6	26056153	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	15348483	26056153	145058914	96	35087											
HIST1H1C	3006	broad.mit.edu	37	chr6	26056548	26056549	+	Frame_Shift_Ins	INS	-	A	A																															agctctgacaccgggggaccINSagacgccttacgaggcgtac																								rs10425	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:26056548_26056549insA	uc003nfw.2	-	1	151_152	c.108_109insT	c.(106-111)TCTGGTfs	p.S36fs		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	36_37	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						ACCGGGGGACCAGACGCCTTAC	0.634													---	---	---								A	26056549	A	A	26056548	7	5	191	1	0	1	1	0	0	0	0	0	7163	594	21	0	536	0	HIST1H1C	6	26056548	Frame_Shift_Ins	INS	-	TCGA-CV-6441-01A-11D-1683-08	395	26056548	145058519	97	35088											
HIST1H2BK	85236	broad.mit.edu	37	chr6	27114365	27114365	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctcacccgcgatgcgttcGaagatgtcgttgacgaagga	9	8	13	11	6	1	2	1	1	0	1	3	6	1	3	2	1	1	2	2	1	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:27114365G>A	uc003nix.1	-	1	255	c.213C>T	c.(211-213)TTC>TTT	p.F71F	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	71					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						CGATGCGTTCGAAGATGTCGT	0.602													86	35					0	0	0	0	A	27114365	A	A	27114365	2	1	191	1	0	0	0	0	0	0	0	1	7189	1049	37	1		1	HIST1H2BK	6	27114365	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	1057817	27114365	144000702	98	35089											
TTBK1	84630	broad.mit.edu	37	chr6	43230556	43230556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggatctgcctggctcgccctCgcgccaggcctgctcctctc	2	9	11	19	3	2	0	0	0	2	0	6	1	3	1	5	3	2	2	5	3	0	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:43230556C>T	uc003ouq.1	+	13	1733	c.1454C>T	c.(1453-1455)TCG>TTG	p.S485L	TTBK1_uc011dvg.1_Missense_Mutation_p.S8L	NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	485						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGCTCGCCCTCGCGCCAGGCC	0.677													5	4					0	0	0	0	T	43230556	T	T	43230556	3	4	191	1	0	0	0	0	1	0	0	0	16744	893	31	1	1500	1	TTBK1	6	43230556	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	16116191	43230556	127884511	99	35090											
POPDC3	64208	broad.mit.edu	37	chr6	105606561	105606561	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtagcgatgctgagcaaaGagcagatataatttctttct	13	13	9	6	1	2	3	0	1	2	2	2	4	2	3	0	0	4	4	0	0	4	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:105606561G>A	uc003prb.2	-	4	1062	c.660C>T	c.(658-660)CTC>CTT	p.L220L	uc003pqz.2_Intron|POPDC3_uc003pra.2_RNA	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	220						integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				GCTGAGCAAAGAGCAGATATA	0.408													46	89					0	0	0	0	A	105606561	A	A	105606561	2	1	191	1	0	0	0	0	0	0	0	1	12311	929	33	2		2	POPDC3	6	105606561	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	62376005	105606561	65508506	100	35091											
PRDM1	639	broad.mit.edu	37	chr6	106547390	106547390	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactttgcagaaaggcttcaCtacccttatcccggagagct	10	10	9	12	1	1	2	1	0	0	2	2	4	2	2	2	2	3	3	2	2	3	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:106547390C>G	uc003prd.2	+	4	861	c.627C>G	c.(625-627)CAC>CAG	p.H209Q	PRDM1_uc003pre.2_Missense_Mutation_p.H75Q	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	209					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		AAAGGCTTCACTACCCTTATC	0.443			D|N|Mis|F|S		DLBCL								16	5					0	0	0	0	G	106547390	G	G	106547390	3	3	191	1	0	0	0	0	1	0	0	0	12512	564	20	4	654	4	PRDM1	6	106547390	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	940829	106547390	64567677	101	35092											
SERAC1	84947	broad.mit.edu	37	chr6	158540196	158540196	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaaggacatctgctttaatGggctgactaataggggagag	14	9	13	5	0	1	2	0	1	1	1	1	4	1	3	0	4	1	2	0	4	5	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:158540196G>A	uc003qrc.2	-	12	1315	c.1173C>T	c.(1171-1173)CCC>CCT	p.P391P	SERAC1_uc003qrb.2_Silent_p.P119P	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	391					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		CTGCTTTAATGGGCTGACTAA	0.423													2	5					0	0	0	0	A	158540196	A	A	158540196	2	1	191	1	0	0	0	0	0	0	0	1	14139	1335	47	4		4	SERAC1	6	158540196	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	51992806	158540196	12574871	102	35093											
QKI	9444	broad.mit.edu	37	chr6	163984469	163984469	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagcagcccttgccttttctCttgcagcaacagcccaggct	7	11	8	15	0	1	0	0	0	1	0	2	0	1	0	3	1	7	4	3	1	2	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr6:163984469C>G	uc003qui.2	+	6	1203	c.652C>G	c.(652-654)CTT>GTT	p.L218V	QKI_uc003que.2_Missense_Mutation_p.L218V|QKI_uc003quf.2_Missense_Mutation_p.L218V|QKI_uc003qug.2_Missense_Mutation_p.L218V|QKI_uc003quh.2_Intron|QKI_uc003quj.2_Intron	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	218					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		TGCCTTTTCTCTTGCAGCAAC	0.498													3	20					0	0	0	0	G	163984469	G	G	163984469	3	3	191	1	0	0	0	0	1	0	0	0	12938	913	32	2	674	2	QKI	6	163984469	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	5444273	163984469	7130598	103	35094											
EIF3B	8662	broad.mit.edu	37	chr7	2412331	2412331	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccatcatagcctttgcctggGaaccaaatggaagtaagttt	12	11	9	9	0	1	0	1	0	0	0	1	2	1	2	4	2	3	2	4	2	5	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:2412331G>A	uc003slx.2	+	12	1794	c.1711G>A	c.(1711-1713)GAA>AAA	p.E571K	EIF3B_uc003sly.2_Missense_Mutation_p.E571K|EIF3B_uc003sma.2_Missense_Mutation_p.E299K	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	571	WD 4.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CTTTGCCTGGGAACCAAATGG	0.438													11	24					0	0	0	0	A	2412331	A	A	2412331	3	1	191	1	0	0	0	0	1	0	0	0	5035	1175	41	2	1757	2	EIF3B	7	2412331	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08		2412331	156726332	104	35095											
LFNG	3955	broad.mit.edu	37	chr7	2566545	2566545	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcccttctcggtggaggccGacccatccaggtaaggaaac	9	6	13	13	2	1	0	0	0	1	0	3	3	2	2	4	6	1	1	4	6	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:2566545G>A	uc003smf.2	+	7	1080	c.1063G>A	c.(1063-1065)GAC>AAC	p.D355N	LFNG_uc003smg.2_Missense_Mutation_p.D355N	NM_001040167	NP_001035257	Q8NES3	LFNG_HUMAN	lunatic fringe isoform a	355	Lumenal (Potential).				organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		GGTGGAGGCCGACCCATCCAG	0.647													5	17					0	0	0	0	A	2566545	A	A	2566545	3	1	191	1	0	0	0	0	1	0	0	0	8777	1058	37	1	1365	1	LFNG	7	2566545	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	154214	2566545	156572118	105	35096											
THSD7A	221981	broad.mit.edu	37	chr7	11676325	11676325	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatctccctcacctgaatacCttcttcccccttaatgcact	8	14	2	17	0	3	1	1	1	2	0	5	1	4	1	5	0	2	1	5	0	4	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:11676325C>T	uc003ssf.3	-	2	706	c.454G>A	c.(454-456)GGT>AGT	p.G152S		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	152	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ACCTGAATACCTTCTTCCCCC	0.488										HNSCC(18;0.044)			16	26					0	0	0	0	T	11676325	T	T	11676325	3	4	191	1	0	0	0	0	1	0	0	0	15945	681	24	4	4623	4	THSD7A	7	11676325	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	9109780	11676325	147462338	106	35097											
ABCB5	340273	broad.mit.edu	37	chr7	20739693	20739693	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttttcagggattattttacGgcagagcaggggaaatttta	11	14	11	5	1	1	1	1	0	0	1	1	3	1	3	0	4	2	2	0	4	4	7			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:20739693G>C	uc003suw.3	+	10	1483	c.937G>C	c.(937-939)GGC>CGC	p.G313R	ABCB5_uc010kuh.2_Missense_Mutation_p.G758R	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	313	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						ATTATTTTACGGCAGAGCAGG	0.303													26	59					0	0	0	0	C	20739693	C	C	20739693	3	2	191	1	0	0	0	0	1	0	0	0	44	1116	39	3	2383	3	ABCB5	7	20739693	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	9063368	20739693	138398970	107	35098											
DNAH11	8701	broad.mit.edu	37	chr7	21678648	21678648	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcgtctcttctgctgatttaCttgacattctctcaaaagga	9	16	6	10	1	4	2	1	2	3	0	7	3	4	3	0	1	2	1	0	1	3	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:21678648C>G	uc003svc.2	+	28	4955	c.4924C>G	c.(4924-4926)CTT>GTT	p.L1642V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1642	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TGCTGATTTACTTGACATTCT	0.398									Kartagener_syndrome				9	48					0	0	0	0	G	21678648	G	G	21678648	3	3	191	1	0	0	0	0	1	0	0	0	4621	565	20	4	5034	4	DNAH11	7	21678648	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	938955	21678648	137460015	108	35099											
GLI3	2737	broad.mit.edu	37	chr7	42079708	42079708	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctacgggaattattgagaatCgtgaccaaggagttgggaga	13	9	14	5	2	0	3	0	2	0	2	1	7	0	5	1	3	1	1	1	3	5	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:42079708C>T	uc011kbh.1	-	7	1048	c.957G>A	c.(955-957)ACG>ACA	p.T319T	GLI3_uc011kbg.1_Silent_p.T260T	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	319					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TATTGAGAATCGTGACCAAGG	0.468									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				7	52					0	0	0	0	T	42079708	T	T	42079708	2	4	191	1	0	0	0	0	0	0	0	1	6476	871	31	1		1	GLI3	7	42079708	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	20401060	42079708	117058955	109	35100											
POLD2	5425	broad.mit.edu	37	chr7	44157600	44157600	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcatggccttgaacagagtgCccaccacacagcacttctcc	10	7	8	16	0	1	2	0	1	1	1	2	2	1	2	4	1	3	2	4	1	1	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:44157600C>T	uc010kxz.2	-	4	934	c.284G>A	c.(283-285)GGC>GAC	p.G95D	POLD2_uc003tke.3_Missense_Mutation_p.G95D|POLD2_uc010kya.2_Missense_Mutation_p.G95D|POLD2_uc003tkf.3_Missense_Mutation_p.G95D	NM_006230	NP_006221	P49005	DPOD2_HUMAN	DNA-directed DNA polymerase delta 2	95					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			ovary(2)	2						GAACAGAGTGCCCACCACACA	0.617													3	59					0	0	0	0	T	44157600	T	T	44157600	3	4	191	1	0	0	0	0	1	0	0	0	12246	739	26	4	1161	4	POLD2	7	44157600	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	2077892	44157600	114981063	110	35101											
TNS3	64759	broad.mit.edu	37	chr7	47476871	47476871	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aactctgtacctttgggttaAgcttcgtaaggtcatatctc	9	15	8	9	1	3	0	1	0	2	0	5	0	3	0	1	2	3	4	1	2	5	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:47476871A>G	uc003tnv.2	-	7	558	c.191T>C	c.(190-192)CTT>CCT	p.L64P	TNS3_uc003tnw.2_Missense_Mutation_p.L64P|TNS3_uc010kyo.1_Missense_Mutation_p.L64P	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	64	Phosphatase tensin-type.					focal adhesion	protein binding			ovary(4)	4						CTTTGGGTTAAGCTTCGTAAG	0.274													21	32					0	0	0	0	G	47476871	G	G	47476871	3	3	191	1	0	0	0	0	1	0	0	0	16410	72	3	5	4246	5	TNS3	7	47476871	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	3319271	47476871	111661792	111	35102											
SUN3	256979	broad.mit.edu	37	chr7	48045610	48045610	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatctcgacttggtcttctCtcaactttttaagtacataa	10	16	4	11	1	4	0	1	0	3	0	6	1	4	0	1	1	2	1	1	1	4	7			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:48045610C>G	uc003tof.2	-	7	630	c.533G>C	c.(532-534)AGA>ACA	p.R178T	SUN3_uc010kyq.2_Missense_Mutation_p.R78T|SUN3_uc003tog.2_Missense_Mutation_p.R178T|SUN3_uc011kcf.1_Missense_Mutation_p.R166T	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	178						integral to membrane				central_nervous_system(1)	1						TTGGTCTTCTCTCAACTTTTT	0.358													7	33					0	0	0	0	G	48045610	G	G	48045610	3	3	191	1	0	0	0	0	1	0	0	0	15459	913	32	2	560	2	SUN3	7	48045610	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	568739	48045610	111093053	112	35103											
POR	5447	broad.mit.edu	37	chr7	75612906	75612907	+	Frame_Shift_Ins	INS	-	G	G																															aagctgaaccagggaaccgaINSgcgccacctcatgcacctgg																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:75612906_75612907insG	uc003udy.2	+	9	981_982	c.899_900insG	c.(898-900)GAGfs	p.E300fs	POR_uc011kgc.1_Frame_Shift_Ins_p.E108fs|POR_uc011kgd.1_Frame_Shift_Ins_p.E199fs|POR_uc011kge.1_Frame_Shift_Ins_p.E38fs|POR_uc003uea.2_5'Flank	NM_000941	NP_000932	P16435	NCPR_HUMAN	cytochrome P450 reductase	297	FAD-binding FR-type.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)	1					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	CAGGGAACCGAGCGCCACCTCA	0.599													---	---	---								G	75612907	G	G	75612906	7	5	191	1	0	1	1	0	0	0	0	0	12312	304	11	0	929	0	POR	7	75612906	Frame_Shift_Ins	INS	-	TCGA-CV-6441-01A-11D-1683-08	27567296	75612906	83525757	113	35104											
HGF	3082	broad.mit.edu	37	chr7	81355326	81355326	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atttcggcagtaattttctcGtaggtccctattgagaataa	11	15	8	7	2	1	1	0	1	1	1	4	2	2	1	1	2	0	3	1	2	5	8			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:81355326G>A	uc003uhl.2	-	9	1213	c.1048C>T	c.(1048-1050)CGA>TGA	p.R350*	HGF_uc003uhm.2_Nonsense_Mutation_p.R345*	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	350	Kringle 3.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						TAATTTTCTCGTAGGTCCCTA	0.418													19	47					0	0	0	0	A	81355326	A	A	81355326	4	1	191	1	0	0	0	0	0	1	0	0	7124	1153	40	1	1178	1	HGF	7	81355326	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	5742420	81355326	77783337	114	35105											
VGF	7425	broad.mit.edu	37	chr7	100806475	100806475	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggctgcagtgtccgcggccgGatgtagttggggaaagggtg	6	8	20	7	3	0	0	0	0	0	0	1	2	1	2	2	6	1	4	2	6	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:100806475G>A	uc003uxx.3	-	2	1868	c.1650C>T	c.(1648-1650)ATC>ATT	p.I550I		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	550					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					TCCGCGGCCGGATGTAGTTGG	0.721													7	53					0	0	0	0	A	100806475	A	A	100806475	2	1	191	1	0	0	0	0	0	0	0	1	17225	1164	41	2		2	VGF	7	100806475	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	19451149	100806475	58332188	115	35106											
SLC26A5	375611	broad.mit.edu	37	chr7	103053458	103053458	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagcttttacctatggataTgtgtctggaggttccaagaa	11	14	10	6	0	1	1	0	0	1	1	2	3	2	3	2	3	2	2	2	3	6	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:103053458T>G	uc003vbz.2	-	5	630	c.394A>C	c.(394-396)ATA>CTA	p.I132L	SLC26A5_uc003vbt.1_Missense_Mutation_p.I132L|SLC26A5_uc003vbu.1_Missense_Mutation_p.I132L|SLC26A5_uc003vbv.1_Missense_Mutation_p.I132L|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.I132L|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	132	Helical; Name=3; (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						CCTATGGATATGTGTCTGGAG	0.373													12	42					0	0	0	0	G	103053458	G	G	103053458	3	3	191	1	0	0	0	0	1	0	0	0	14584	1464	51	5	1945	5	SLC26A5	7	103053458	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	2246983	103053458	56085205	116	35107											
PNPLA8	50640	broad.mit.edu	37	chr7	108154982	108154982	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctgttcttctgactgactCtttgaatcatactttaattt	8	20	4	9	0	4	3	1	3	3	0	5	3	5	3	1	0	1	1	1	0	3	7			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:108154982C>G	uc003vff.1	-	4	1361	c.954G>C	c.(952-954)AAG>AAC	p.K318N	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Missense_Mutation_p.K318N|PNPLA8_uc003vfi.1_Missense_Mutation_p.K218N|PNPLA8_uc003vfj.1_Missense_Mutation_p.K318N|PNPLA8_uc003vfk.1_Missense_Mutation_p.K218N	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	318					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						CTGACTGACTCTTTGAATCAT	0.413													30	156					0	0	0	0	G	108154982	G	G	108154982	3	3	191	1	0	0	0	0	1	0	0	0	12226	912	32	2	1430	2	PNPLA8	7	108154982	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	5101524	108154982	50983681	117	35108											
C7orf60	154743	broad.mit.edu	37	chr7	112461999	112461999	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgttgaaatcttgaggaaTatataacattcctgggtagt	13	14	9	5	0	1	2	0	2	1	0	2	3	2	3	1	2	1	2	1	2	6	7			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:112461999T>C	uc003vgo.1	-	5	1145	c.1018A>G	c.(1018-1020)ATT>GTT	p.I340V	C7orf60_uc011kms.1_Missense_Mutation_p.I366V	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	340										ovary(2)|skin(1)	3						TCTTGAGGAATATATAACATT	0.294													4	37					0	0	0	0	C	112461999	C	C	112461999	3	2	191	1	0	0	0	0	1	0	0	0	2418	1406	49	5	203	5	C7orf60	7	112461999	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	4307017	112461999	46676664	118	35109											
ING3	54556	broad.mit.edu	37	chr7	120613295	120613295	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgggatgtgataaccaaGatgtaagtattacatttttc	12	15	10	4	0	0	2	0	1	0	1	1	3	0	3	1	2	2	2	1	2	5	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:120613295G>C	uc003vjn.2	+	11	1272	c.1138G>C	c.(1138-1140)GAT>CAT	p.D380H	ING3_uc003vjo.2_Missense_Mutation_p.D154H|ING3_uc003vjp.2_3'UTR|ING3_uc011kns.1_Missense_Mutation_p.D365H	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	380	PHD-type.			Missing (in Ref. 5; CAC48260).	histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					TGATAACCAAGATGTAAGTAT	0.284													15	62					0	0	0	0	C	120613295	C	C	120613295	3	2	191	1	0	0	0	0	1	0	0	0	7776	942	33	2	1196	2	ING3	7	120613295	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	8151296	120613295	38525368	119	35110											
ASB10	136371	broad.mit.edu	37	chr7	150878413	150878413	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcattgcgggcatcaggacaTgccccccgtcttagaagcag	9	7	12	13	2	2	1	1	0	1	1	2	2	2	2	3	2	3	3	3	2	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr7:150878413T>C	uc003wjm.1	-	3	978	c.852A>G	c.(850-852)GCA>GCG	p.A284A	ASB10_uc003wjl.1_Silent_p.A284A|ASB10_uc003wjn.1_Silent_p.A224A	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	239	ANK 4.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATCAGGACATGCCCCCCGTC	0.652													5	15					0	0	0	0	C	150878413	C	C	150878413	2	2	191	1	0	0	0	0	0	0	0	1	1016	1451	51	5		5	ASB10	7	150878413	Silent	SNP	T	TCGA-CV-6441-01A-11D-1683-08	30265118	150878413	8260250	120	35111											
FGF20	26281	broad.mit.edu	37	chr8	16850824	16850824	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcattcggaagtaagtttCtcctgaaagagagaagataa	16	10	10	5	1	1	4	0	1	1	3	3	6	1	5	1	1	1	3	1	1	5	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:16850824C>G	uc003wxc.1	-	3	526	c.393G>C	c.(391-393)GAG>GAC	p.E131D	FGF20_uc010lsv.1_RNA|FGF20_uc010lsw.1_Missense_Mutation_p.E97Q	NM_019851	NP_062825	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	131					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			lung(1)	1				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		AAGTAAGTTTCTCCTGAAAGA	0.333													45	132					0	0	0	0	G	16850824	G	G	16850824	3	3	191	1	0	0	0	0	1	0	0	0	5881	912	32	2	246	2	FGF20	8	16850824	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08		16850824	129513198	121	35112											
LPL	4023	broad.mit.edu	37	chr8	19810909	19810909	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattgcaggaagtctgaccaAtaagaaagtcaacagaatta	18	8	8	7	0	2	3	1	1	1	2	2	4	2	4	1	1	2	1	1	1	7	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:19810909A>T	uc003wzk.3	+	4	888	c.518A>T	c.(517-519)AAT>ATT	p.N173I		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	173					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	AGTCTGACCAATAAGAAAGTC	0.413													29	41					0	0	0	0	T	19810909	T	T	19810909	3	4	191	1	0	0	0	0	1	0	0	0	8971	101	4	5	532	5	LPL	8	19810909	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	2960085	19810909	126553113	122	35113											
MCM4	4173	broad.mit.edu	37	chr8	48887407	48887407	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catgctaaagtaagattgtcTaacaaagttgaagccattga	16	11	8	6	0	1	3	0	2	1	1	1	3	1	3	1	0	3	3	1	0	6	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:48887407T>A	uc003xqk.1	+	15	2345	c.2250T>A	c.(2248-2250)TCT>TCA	p.S750S	MCM4_uc003xql.1_Silent_p.S750S|MCM4_uc011ldi.1_Silent_p.S737S	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	750					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				TAAGATTGTCTAACAAAGTTG	0.498													12	159					0	0	0	0	A	48887407	A	A	48887407	2	1	191	1	0	0	0	0	0	0	0	1	9442	1509	53	5		5	MCM4	8	48887407	Silent	SNP	T	TCGA-CV-6441-01A-11D-1683-08	29076498	48887407	97476615	123	35114											
SNTG1	54212	broad.mit.edu	37	chr8	51705261	51705261	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctaatttatttgctgttCttcactgcattcattccttc	6	22	3	10	0	4	0	2	0	2	0	6	0	5	0	1	0	2	3	1	0	2	10			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:51705261C>G	uc010lxy.1	+	20	1797	c.1426C>G	c.(1426-1428)CTT>GTT	p.L476V	SNTG1_uc003xqs.1_Missense_Mutation_p.L476V|SNTG1_uc010lxz.1_Missense_Mutation_p.L439V|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	476					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				ATTTGCTGTTCTTCACTGCAT	0.363													18	101					0	0	0	0	G	51705261	G	G	51705261	3	3	191	1	0	0	0	0	1	0	0	0	14938	913	32	2	1492	2	SNTG1	8	51705261	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	2817854	51705261	94658761	124	35115											
TGS1	96764	broad.mit.edu	37	chr8	56698298	56698298	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaccaggcgacagaagaaGaggaaggtggttattcctgt	13	7	15	6	1	0	4	0	0	0	4	1	7	1	5	2	4	0	1	2	4	4	2	rs139226926	byFrequency	TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:56698298G>C	uc003xsj.3	+	3	574	c.187G>C	c.(187-189)GAG>CAG	p.E63Q	TGS1_uc010lyh.2_5'UTR	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	63					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			GACAGAAGAAGAGGAAGGTGG	0.338													10	37					0	0	0	0	C	56698298	C	C	56698298	3	2	191	1	0	0	0	0	1	0	0	0	15903	943	33	2	197	2	TGS1	8	56698298	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	4993037	56698298	89665724	125	35116											
FAM110B	90362	broad.mit.edu	37	chr8	59059795	59059795	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaatgatgacagtgccaatGaccgcgtgccgtatggcatt	11	9	12	9	3	0	3	0	3	0	0	0	4	0	3	3	1	2	2	3	1	3	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:59059795G>A	uc003xtj.1	+	5	1886	c.1006G>A	c.(1006-1008)GAC>AAC	p.D336N		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	336						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CAGTGCCAATGACCGCGTGCC	0.458													12	13					0	0	0	0	A	59059795	A	A	59059795	3	1	191	1	0	0	0	0	1	0	0	0	5425	1290	45	2	1008	2	FAM110B	8	59059795	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	2361497	59059795	87304227	126	35117											
PAG1	55824	broad.mit.edu	37	chr8	81899630	81899630	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccattggtgagtgccccattCtgctcactgctggcaggagc	6	10	12	13	0	2	1	1	1	1	0	2	2	2	2	3	3	4	3	3	3	0	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:81899630C>T	uc003ybz.2	-	6	960	c.249G>A	c.(247-249)CAG>CAA	p.Q83Q		NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid	83	Cytoplasmic (Potential).				epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			GTGCCCCATTCTGCTCACTGC	0.438													12	62					0	0	0	0	T	81899630	T	T	81899630	2	4	191	1	0	0	0	0	0	0	0	1	11442	912	32	2		2	PAG1	8	81899630	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	22839835	81899630	64464392	127	35118											
ENY2	56943	broad.mit.edu	37	chr8	110348368	110348368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgtccaggttagcaagatGaacaaagatgcgcagatgag	15	7	13	6	1	0	5	0	2	0	3	1	6	1	5	1	1	3	3	1	1	4	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:110348368G>A	uc003ynd.2	+	2	80	c.18G>A	c.(16-18)ATG>ATA	p.M6I	NUDCD1_uc003ynb.3_5'Flank|NUDCD1_uc010mcl.2_5'Flank|ENY2_uc003ync.2_Missense_Mutation_p.M1I	NM_020189	NP_064574	Q9NPA8	ENY2_HUMAN	enhancer of yellow 2 homolog	6					histone deubiquitination|mRNA transport|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity				0	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;9.05e-13)			TTAGCAAGATGAACAAAGATG	0.358													8	13					0	0	0	0	A	110348368	A	A	110348368	3	1	191	1	0	0	0	0	1	0	0	0	5170	1290	45	2	24	2	ENY2	8	110348368	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	28448738	110348368	36015654	128	35119											
SYBU	55638	broad.mit.edu	37	chr8	110590243	110590243	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caagacatgtaccttccagaAcgcctgaaacaatccaagta	16	7	6	12	1	0	3	0	1	0	2	2	3	2	3	4	0	3	2	4	0	7	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr8:110590243A>G	uc003ynj.3	-	6	901	c.738T>C	c.(736-738)CGT>CGC	p.R246R	SYBU_uc003yni.3_Silent_p.R243R|SYBU_uc003ynk.3_Silent_p.R127R|SYBU_uc010mco.2_Silent_p.R245R|SYBU_uc003ynl.3_Silent_p.R245R|SYBU_uc010mcp.2_Silent_p.R246R|SYBU_uc010mcq.2_Silent_p.R246R|SYBU_uc003yno.3_Silent_p.R127R|SYBU_uc010mcr.2_Silent_p.R246R|SYBU_uc003ynm.3_Silent_p.R245R|SYBU_uc003ynn.3_Silent_p.R245R|SYBU_uc010mcs.2_Silent_p.R127R|SYBU_uc010mct.2_Silent_p.R246R|SYBU_uc010mcu.2_Silent_p.R245R|SYBU_uc003ynp.3_Silent_p.R178R|SYBU_uc010mcv.2_Silent_p.R246R|SYBU_uc003ynh.3_Silent_p.R40R|SYBU_uc011lhw.1_Silent_p.R116R	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	246	Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						ACCTTCCAGAACGCCTGAAAC	0.378													30	113					0	0	0	0	G	110590243	G	G	110590243	2	3	191	1	0	0	0	0	0	0	0	1	15493	30	2	5		5	SYBU	8	110590243	Silent	SNP	A	TCGA-CV-6441-01A-11D-1683-08	241875	110590243	35773779	129	35120											
PTPRD	5789	broad.mit.edu	37	chr9	8471058	8471058	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatttcccgcgagatttcttCaaaggcacaattattatgta	13	14	6	8	2	2	1	1	0	1	1	3	2	3	1	1	1	0	2	1	1	6	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:8471058C>G	uc003zkk.2	-	30	4152	c.3441G>C	c.(3439-3441)TTG>TTC	p.L1147F	PTPRD_uc003zkp.2_Missense_Mutation_p.L736F|PTPRD_uc003zkq.2_Missense_Mutation_p.L736F|PTPRD_uc003zkr.2_Missense_Mutation_p.L731F|PTPRD_uc003zks.2_Missense_Mutation_p.L726F|PTPRD_uc003zkl.2_Missense_Mutation_p.L1138F|PTPRD_uc003zkm.2_Missense_Mutation_p.L1134F|PTPRD_uc003zkn.2_Missense_Mutation_p.L736F|PTPRD_uc003zko.2_Missense_Mutation_p.L733F	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1147	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAGATTTCTTCAAAGGCACAA	0.378										TSP Lung(15;0.13)			40	18					0	0	0	0	G	8471058	G	G	8471058	3	3	191	1	0	0	0	0	1	0	0	0	12864	825	29	2	2426	2	PTPRD	9	8471058	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08		8471058	132742373	130	35121											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18753314	18753314	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggtgggaaattggcaagtgGagtccatgtagtctcacatg	11	10	14	6	0	1	0	1	0	1	0	3	2	2	2	1	4	0	2	1	4	3	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:18753314G>A	uc003zne.3	+	16	2152	c.2025G>A	c.(2023-2025)TGG>TGA	p.W675*		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	675	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		TTGGCAAGTGGAGTCCATGTA	0.488													10	2					0	0	0	0	A	18753314	A	A	18753314	4	1	191	1	0	0	0	0	0	1	0	0	274	1183	41	2	2091	2	ADAMTSL1	9	18753314	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	10282256	18753314	122460117	131	35122											
FAM154A	158297	broad.mit.edu	37	chr9	18928327	18928327	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacagcttttggtattgataGgcaggtggggcacatagtgg	9	12	15	5	0	0	1	0	1	0	0	0	1	0	1	0	6	2	4	0	6	4	7			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:18928327G>T	uc003zni.1	-	4	1426	c.1148C>A	c.(1147-1149)CCT>CAT	p.P383H	FAM154A_uc010mip.1_Missense_Mutation_p.P191H	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	383										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		GGTATTGATAGGCAGGTGGGG	0.582													8	33					0.000157383	0.000162612	1	0	T	18928327	T	T	18928327	3	4	191	1	0	0	0	0	1	0	0	0	5491	1000	35	4	280	4	FAM154A	9	18928327	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	175013	18928327	122285104	132	35123											
C9orf131	138724	broad.mit.edu	37	chr9	35044434	35044434	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgggcctctaagcaccCagcttgtaacttaccccaag	9	9	7	16	0	1	0	0	0	1	0	2	0	2	0	5	1	4	3	5	1	4	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:35044434C>T	uc003zvw.2	+	2	1837	c.1808C>T	c.(1807-1809)CCA>CTA	p.P603L	C9orf131_uc003zvu.2_Missense_Mutation_p.P555L|C9orf131_uc003zvv.2_Missense_Mutation_p.P530L|C9orf131_uc003zvx.2_Missense_Mutation_p.P568L	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	603											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TCTAAGCACCCAGCTTGTAAC	0.493													31	101					0	0	0	0	T	35044434	T	T	35044434	3	4	191	1	0	0	0	0	1	0	0	0	2469	594	21	4	1830	4	C9orf131	9	35044434	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	16116107	35044434	106168997	133	35124											
C9orf131	138724	broad.mit.edu	37	chr9	35044709	35044709	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagctcactctctactcctCtaccagagccacacattgac	10	9	4	18	0	3	2	1	1	2	1	5	2	4	2	4	0	4	1	4	0	2	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:35044709C>G	uc003zvw.2	+	2	2112	c.2083C>G	c.(2083-2085)CTA>GTA	p.L695V	C9orf131_uc003zvu.2_Missense_Mutation_p.L647V|C9orf131_uc003zvv.2_Missense_Mutation_p.L622V|C9orf131_uc003zvx.2_Missense_Mutation_p.L660V	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	695											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CTCTACTCCTCTACCAGAGCC	0.562													13	30					0	0	0	0	G	35044709	G	G	35044709	3	3	191	1	0	0	0	0	1	0	0	0	2469	912	32	2	2105	2	C9orf131	9	35044709	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	275	35044709	106168722	134	35125											
ECM2	1842	broad.mit.edu	37	chr9	95256393	95256393	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggaaaggccacatctgatCtgtttgtcactgtctctaga	10	12	10	9	0	4	2	1	1	3	1	5	4	4	3	1	2	0	1	1	2	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:95256393C>T	uc004asf.3	-	10	2054	c.1904G>A	c.(1903-1905)AGA>AAA	p.R635K	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	Error:Variant_position_missing_in_O94769_after_alignment					cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						CACATCTGATCTGTTTGTCAC	0.413													11	60					0	0	0	0	T	95256393	T	T	95256393	3	4	191	1	0	0	0	0	1	0	0	0	4920	928	32	2		2	ECM2	9	95256393	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	60211684	95256393	45957038	135	35126											
PAEP	5047	broad.mit.edu	37	chr9	138454276	138454276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctggagatcgttctgcacaGatggtgggtttctcatcatt	7	14	11	9	1	3	2	2	0	2	2	5	3	3	2	1	3	1	3	1	3	0	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:138454276G>A	uc004cge.1	+	2	277	c.233G>A	c.(232-234)AGA>AAA	p.R78K	PAEP_uc010naw.1_Missense_Mutation_p.R56K|PAEP_uc010naz.2_RNA|PAEP_uc010nay.2_Missense_Mutation_p.R78K|PAEP_uc010nba.1_Missense_Mutation_p.R78K|PAEP_uc004cgd.1_Missense_Mutation_p.R78K|PAEP_uc011mdp.1_Missense_Mutation_p.R56K|PAEP_uc004cgg.1_Missense_Mutation_p.R78K|PAEP_uc010nbc.1_Missense_Mutation_p.R78K|PAEP_uc004cgf.1_Missense_Mutation_p.R78K	NM_001018049	NP_001018059	P09466	PAEP_HUMAN	glycodelin precursor	78					multicellular organismal development	extracellular region	binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		GTTCTGCACAGATGGTGGGTT	0.622													11	80					0	0	0	0	A	138454276	A	A	138454276	3	1	191	1	0	0	0	0	1	0	0	0	11436	942	33	2	239	2	PAEP	9	138454276	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	43197883	138454276	2759155	136	35127											
C9orf173	441476	broad.mit.edu	37	chr9	140145786	140145788	+	In_Frame_Del	DEL	CAT	-	-																															aaattcctggcaaatttttaCatcaatggaggcaaacactg																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr9:140145786_140145788delCAT	uc004cmk.1	+	1	57_59	c.45_47delCAT	c.(43-48)TACATC>TAC	p.I16del	C9orf173_uc004cmj.1_In_Frame_Del_p.I17del|C9orf173_uc011meu.1_RNA|C9orf173_uc010ncd.1_RNA|C9orf173_uc011mev.1_In_Frame_Del_p.I16del|C9orf173_uc004cml.1_In_Frame_Del_p.I16del			Q8N7X2	CI173_HUMAN	SubName: Full=LOC441476 protein;	17										pancreas(1)	1						CAAATTTTTACATCAATGGAGGC	0.567													---	---	---								-	140145788	-	-	140145786	7	5	191	1	0	1	0	1	0	0	0	0	2484	489	17	0	50	0	C9orf173	9	140145786	In_Frame_Del	DEL	CAT	TCGA-CV-6441-01A-11D-1683-08	1691510	140145786	1067645	137	35128											
DIP2C	22982	broad.mit.edu	37	chr10	329222	329222	+	Frame_Shift_Del	DEL	A	-	-																															ggactctcacctccatttgcAtctgtgagctcagttctccg																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:329222delA	uc001ifp.2	-	35	4374	c.4284delT	c.(4282-4284)GATfs	p.D1428fs		NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	1428						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CTCCATTTGCATCTGTGAGCT	0.547													---	---	---								-	329222	-	-	329222	7	5	191	1	0	1	0	1	0	0	0	0	4551	214	8	0	398	0	DIP2C	10	329222	Frame_Shift_Del	DEL	A	TCGA-CV-6441-01A-11D-1683-08		329222	135205525	138	35129											
CUBN	8029	broad.mit.edu	37	chr10	17147564	17147564	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgggagacacgtgcagagAggtaaggaacctgttcagaa	13	5	14	9	2	1	3	1	0	0	3	1	6	1	4	2	3	2	3	2	3	3	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:17147564A>T	uc001ioo.2	-	11	1174	c.1122T>A	c.(1120-1122)CCT>CCA	p.P374P		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	374	EGF-like 5.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACGTGCAGAGAGGTAAGGAAC	0.443													19	28					0	0	0	0	T	17147564	T	T	17147564	2	4	191	1	0	0	0	0	0	0	0	1	4068	291	11	5		5	CUBN	10	17147564	Silent	SNP	A	TCGA-CV-6441-01A-11D-1683-08	16818342	17147564	118387183	139	35130											
VIM	7431	broad.mit.edu	37	chr10	17278348	17278348	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactcaaaaaggacacttctGattaagacggttgaaactag	16	9	8	8	1	2	3	1	2	1	1	2	4	2	4	0	2	1	1	0	2	5	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:17278348G>A	uc001iou.2	+	9	1742	c.1329G>A	c.(1327-1329)CTG>CTA	p.L443L	VIM_uc001iov.1_Intron|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Silent_p.L443L|VIM_uc001ioy.1_Silent_p.L356L|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Silent_p.L401L|VIM_uc001ipc.1_Intron	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	443	Tail.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						GGACACTTCTGATTAAGACGG	0.348													63	117					0	0	0	0	A	17278348	A	A	17278348	2	1	191	1	0	0	0	0	0	0	0	1	17234	1277	45	2		2	VIM	10	17278348	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	130784	17278348	118256399	140	35131											
ENKUR	219670	broad.mit.edu	37	chr10	25284722	25284722	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttataaaattttttccactCtgtattcccatgacaggatg	11	17	5	8	0	1	1	0	1	1	0	3	2	3	2	2	1	0	1	2	1	4	8			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:25284722C>T	uc001isg.1	-	3	465	c.300G>A	c.(298-300)CAG>CAA	p.Q100Q	ENKUR_uc001ish.1_Silent_p.Q38Q	NM_145010	NP_659447	Q8TC29	ENKUR_HUMAN	enkurin	100						cilium|flagellum	calmodulin binding|SH3 domain binding				0						TTTTTCCACTCTGTATTCCCA	0.358													27	94					0	0	0	0	T	25284722	T	T	25284722	2	4	191	1	0	0	0	0	0	0	0	1	5144	912	32	2		2	ENKUR	10	25284722	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	8006374	25284722	110250025	141	35132											
ZNF239	8187	broad.mit.edu	37	chr10	44052584	44052584	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cacactcatagggcttctctCcagtgtggactcgctggtgg	6	11	12	12	1	2	0	1	0	1	0	5	1	3	1	1	4	0	2	1	4	1	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:44052584C>G	uc001jaw.3	-	2	1597	c.944G>C	c.(943-945)GGA>GCA	p.G315A	ZNF239_uc001jax.3_Missense_Mutation_p.G315A|ZNF239_uc009xmj.2_Missense_Mutation_p.G315A|ZNF239_uc009xmk.2_Missense_Mutation_p.G315A	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						GGGCTTCTCTCCAGTGTGGAC	0.522													15	68					0	0	0	0	G	44052584	G	G	44052584	3	3	191	1	0	0	0	0	1	0	0	0	17858	855	30	2	436	2	ZNF239	10	44052584	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	18767862	44052584	91482163	142	35133											
JMJD1C	221037	broad.mit.edu	37	chr10	64968896	64968896	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aattttaagaggccgatgagGctctgcactggaaggtctga	11	10	13	7	1	2	3	0	2	2	1	2	5	2	4	1	4	1	2	1	4	3	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:64968896G>T	uc001jmn.2	-	9	3094	c.2794C>A	c.(2794-2796)CCT>ACT	p.P932T	JMJD1C_uc001jml.2_Missense_Mutation_p.P713T|JMJD1C_uc001jmm.2_Missense_Mutation_p.P644T|JMJD1C_uc010qiq.1_Missense_Mutation_p.P750T|JMJD1C_uc009xpi.2_Missense_Mutation_p.P750T|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_5'Flank	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	932					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GGCCGATGAGGCTCTGCACTG	0.443													57	44					2.2129e-31	2.53019e-31	1	0	T	64968896	T	T	64968896	3	4	191	1	0	0	0	0	1	0	0	0	7989	1203	42	4	4900	4	JMJD1C	10	64968896	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	20916312	64968896	70565851	143	35134											
LDB3	11155	broad.mit.edu	37	chr10	88428385	88428385	+	5'Flank	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgggcaggcggagtgcctGagtgccctctcactcaaccc	7	6	12	16	2	2	1	2	1	1	0	3	2	2	2	4	3	3	1	4	3	1	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:88428385G>C	uc001kdv.2	+						LDB3_uc010qml.1_Intron|LDB3_uc010qmm.1_Intron|LDB3_uc001kdu.2_5'Flank|LDB3_uc009xsz.2_5'Flank|LDB3_uc001kdr.2_5'UTR|LDB3_uc009xsy.2_5'Flank|LDB3_uc001kds.2_5'Flank|LDB3_uc001kdt.2_5'Flank	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1							cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						CGGAGTGCCTGAGTGCCCTCT	0.662													5	27					0	0	0	0	C	88428385	C	C	88428385	1	2	191	0	1	0	0	0	0	0	0	0	8737	1305	45	2		2	LDB3	10	88428385	5'Flank	SNP	G	TCGA-CV-6441-01A-11D-1683-08	23459489	88428385	47106362	144	35135											
HTR7	3363	broad.mit.edu	37	chr10	92508597	92508598	+	Silent	DNP	GC	AA	AA																															tagtgataaatgaccttacaGcacaaactcaggtctctctg																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:92508597_92508598GC>AA	uc001kha.2	-	2	1536_1537	c.1293_1294GC>TT	c.(1291-1296)GTGCTG>GTTTTG	p.431_432VL>VL	HTR7_uc001kgz.2_Silent_p.431_432VL>VL|HTR7_uc001khb.2_Silent_p.431_432VL>VL	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	431_432	Cytoplasmic (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	TGACCTTACAGCACAAACTCAG	0.48													45	108					0	0	0	0	AA	92508598	AA	AA	92508597	2	1	191	1	0	0	0	0	0	0	0	1	7491	985	34	4		4	HTR7	10	92508597	Silent	DNP	GC	TCGA-CV-6441-01A-11D-1683-08	4080212	92508597	43026150	145	35136											
PLCE1	51196	broad.mit.edu	37	chr10	95892095	95892095	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgtgagtatcgcgccaccctCcaaaggacttcaatatcgca	11	9	8	13	3	1	1	1	1	0	0	4	2	2	2	3	1	0	2	3	1	4	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:95892095C>G	uc001kjk.2	+	3	2005	c.1371C>G	c.(1369-1371)CTC>CTG	p.L457L	PLCE1_uc010qnx.1_Silent_p.L457L|PLCE1_uc001kjm.2_Silent_p.L149L	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	457					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GCGCCACCCTCCAAAGGACTT	0.517													65	64					0	0	0	0	G	95892095	G	G	95892095	2	3	191	1	0	0	0	0	0	0	0	1	12089	842	30	2		2	PLCE1	10	95892095	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	3383498	95892095	39642652	146	35137											
C10orf84	63877	broad.mit.edu	37	chr10	120094625	120094625	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atgcaataacaaagatattaCcttctcaacttttttccttt	13	17	2	9	0	1	1	1	0	1	1	3	1	2	1	2	0	4	1	2	0	6	8			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:120094625C>A	uc001ldo.2	-	6	720	c.453_splice	c.e6+1	p.K151_splice	C10orf84_uc010qss.1_Splice_Site_p.K151_splice	NM_022063	NP_071346	Q9H8W3	F204A_HUMAN	hypothetical protein LOC63877												0		Colorectal(252;0.101)		all cancers(201;0.0244)		AAAGATATTACCTTCTCAACT	0.363													6	51					0.00307968	0.00314026	1	0	A	120094625	A	A	120094625	5	1	191	1	0	0	0	0	0	0	1	0	1627	521	18	4	263	4	C10orf84	10	120094625	Splice_Site	SNP	C	TCGA-CV-6441-01A-11D-1683-08	24202530	120094625	15440122	147	35138											
KNDC1	85442	broad.mit.edu	37	chr10	135020757	135020757	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggacgagtcctcctcgctCatcttctacaacgtcaacaa	10	10	6	15	3	4	0	2	0	2	0	7	2	6	1	2	1	3	1	2	1	4	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr10:135020757C>T	uc001llz.1	+	20	3697	c.3696C>T	c.(3694-3696)CTC>CTT	p.L1232L		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1232					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CCTCCTCGCTCATCTTCTACA	0.677													12	60					0	0	0	0	T	135020757	T	T	135020757	2	4	191	1	0	0	0	0	0	0	0	1	8465	813	29	2		2	KNDC1	10	135020757	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	14926132	135020757	513990	148	35139											
OR51G1	79324	broad.mit.edu	37	chr11	4944942	4944942	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gatgagcagggagtccacacCcacggtgcaggccacaacaa	13	3	12	13	1	0	1	0	1	0	0	1	3	1	2	3	3	3	2	3	3	2	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:4944942C>T	uc010qyr.1	-	1	628	c.628G>A	c.(628-630)GGT>AGT	p.G210S		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGTCCACACCCACGGTGCAG	0.552													8	28					0	0	0	0	T	4944942	T	T	4944942	3	4	191	1	0	0	0	0	1	0	0	0	11152	623	22	4	339	4	OR51G1	11	4944942	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08		4944942	130061574	149	35140											
ELP4	26610	broad.mit.edu	37	chr11	31625408	31625408	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggcttcaaattggcatggaTtttttcttccagagaaaata	13	14	8	6	0	2	1	1	0	1	1	3	3	3	2	1	3	0	2	1	3	4	7			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:31625408T>G	uc001mtb.2	+	5	642	c.607T>G	c.(607-609)TTT>GTT	p.F203V	ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Missense_Mutation_p.F203V|ELP4_uc010rdz.1_Missense_Mutation_p.F204V	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	203					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					TTGGCATGGATTTTTTCTTCC	0.328													21	58					0	0	0	0	G	31625408	G	G	31625408	3	3	191	1	0	0	0	0	1	0	0	0	5106	1493	52	5	625	5	ELP4	11	31625408	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	26680466	31625408	103381108	150	35141											
OR8H2	390151	broad.mit.edu	37	chr11	55872567	55872567	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggctgacttcatccttatgGgactgacactttctgaagag	9	13	10	9	0	2	4	1	3	1	1	3	5	3	5	1	2	0	1	1	2	2	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:55872567G>A	uc010riy.1	+	1	49	c.49G>A	c.(49-51)GGA>AGA	p.G17R		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CATCCTTATGGGACTGACACT	0.408										HNSCC(53;0.14)			28	124					0	0	0	0	A	55872567	A	A	55872567	3	1	191	1	0	0	0	0	1	0	0	0	11292	1233	43	4	51	4	OR8H2	11	55872567	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	24247159	55872567	79133949	151	35142											
SSRP1	6749	broad.mit.edu	37	chr11	57100270	57100270	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagctcccggaagatgcaGatggcatctcccgtggcctg	7	8	13	13	2	1	2	0	0	1	2	3	3	2	3	3	3	3	4	3	3	1	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:57100270G>A	uc001njt.2	-	6	864	c.597C>T	c.(595-597)ATC>ATT	p.I199I	SSRP1_uc010rjq.1_Silent_p.I199I	NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	199					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						GGAAGATGCAGATGGCATCTC	0.537													8	32					0	0	0	0	A	57100270	A	A	57100270	2	1	191	1	0	0	0	0	0	0	0	1	15260	932	33	2		2	SSRP1	11	57100270	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	1227703	57100270	77906246	152	35143											
TMEM109	79073	broad.mit.edu	37	chr11	60689394	60689394	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggcggatcctgtggggcctGaagcttgtcatcttcctggc	4	11	15	11	1	2	1	1	1	1	0	4	2	4	2	3	5	1	1	3	5	1	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:60689394G>C	uc001nqg.2	+	4	867	c.489G>C	c.(487-489)CTG>CTC	p.L163L	TMEM109_uc001nqh.2_Silent_p.L163L|TMEM132A_uc001nqi.2_5'Flank|TMEM132A_uc001nqj.2_5'Flank	NM_024092	NP_076997	Q9BVC6	TM109_HUMAN	transmembrane protein 109 precursor	163	Helical; (Potential).					integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane					0						TGTGGGGCCTGAAGCTTGTCA	0.652													25	88					0	0	0	0	C	60689394	C	C	60689394	2	2	191	1	0	0	0	0	0	0	0	1	16091	1277	45	2		2	TMEM109	11	60689394	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	3589124	60689394	74317122	153	35144											
STIP1	10963	broad.mit.edu	37	chr11	63965417	63965417	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtctctggcagagcaccgaAccccagatgtgctcaagaaa	13	6	10	12	1	2	3	1	0	1	3	3	4	2	3	3	1	3	3	3	1	3	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:63965417A>G	uc001nyk.1	+	8	1141	c.994A>G	c.(994-996)ACC>GCC	p.T332A	STIP1_uc010rnb.1_Missense_Mutation_p.T308A	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	332	TPR 6.				axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3						AGAGCACCGAACCCCAGATGT	0.403													5	155					0	0	0	0	G	63965417	G	G	63965417	3	3	191	1	0	0	0	0	1	0	0	0	15351	43	2	5	1024	5	STIP1	11	63965417	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	3276023	63965417	71041099	154	35145											
EHD1	10938	broad.mit.edu	37	chr11	64645866	64645866	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgcgtacagctgccgcagcCcctcagccaccgtctggaag	7	5	12	17	4	2	0	1	0	1	0	2	1	2	1	5	1	5	3	5	1	2	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:64645866C>A	uc001obu.1	-	1	326	c.71G>T	c.(70-72)GGG>GTG	p.G24V	EHD1_uc001obv.1_Missense_Mutation_p.G24V|EHD1_uc010rnq.1_Missense_Mutation_p.G38V	NM_006795	NP_006786	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	24					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding				0						CTGCCGCAGCCCCTCAGCCAC	0.582													16	19					2.89027e-11	3.13196e-11	1	0	A	64645866	A	A	64645866	3	1	191	1	0	0	0	0	1	0	0	0	4999	623	22	4	1553	4	EHD1	11	64645866	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	680449	64645866	70360650	155	35146											
DPP3	10072	broad.mit.edu	37	chr11	66272197	66272197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagggacacggtgctgctgCgtaaggaatctcggaagctc	9	8	14	10	3	2	0	1	0	1	0	4	3	2	3	0	4	4	4	0	4	3	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:66272197C>T	uc001oig.1	+	17	2055	c.1993C>T	c.(1993-1995)CGT>TGT	p.R665C	DPP3_uc001oif.1_Missense_Mutation_p.R665C|DPP3_uc010rpe.1_Missense_Mutation_p.R654C|DPP3_uc001oih.1_Silent_p.C32C	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	665					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						GGTGCTGCTGCGTAAGGAATC	0.592													19	71					0	0	0	0	T	66272197	T	T	66272197	3	4	191	1	0	0	0	0	1	0	0	0	4750	768	27	1	2055	1	DPP3	11	66272197	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	1626331	66272197	68734319	156	35147											
CCND1	595	broad.mit.edu	37	chr11	69466006	69466006	+	Missense_Mutation	SNP	G	C	C																															aagaggaggaggaggaggtgGacctggcttgcacacccacc																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:69466006G>C	uc001opa.2	+	5	1053	c.844G>C	c.(844-846)GAC>CAC	p.D282H		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	282					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	ggaggaggtggaCCTGGCTTG	0.612			T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			8	4					0	0	0	0	C	69466006	C	C	69466006	3	2	191	1	0	0	0	0	1	0	0	0	2931	1174	41	2	862	2	CCND1	11	69466006	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	3193809	69466006	65540510	157	35148	68	2									
CCND1	595	broad.mit.edu	37	chr11	69466013	69466021	+	In_Frame_Del	DEL	CTTGCACAC	-	-																															ggaggaggaggtggacctggCttgcacacccaccgacgtgc																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:69466013_69466021delCTTGCACAC	uc001opa.2	+	5	1060_1068	c.851_859delCTTGCACAC	c.(850-861)GCTTGCACACCC>GCC	p.CTP285del		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	285_287					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	gtggaCCTGGCTTGCACACCCACCGACGT	0.612			T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			---	---	---								-	69466021	-	-	69466013	7	5	191	1	0	1	0	1	0	0	0	0	2931	797	28	0	869	0	CCND1	11	69466013	In_Frame_Del	DEL	CTTGCACAC	TCGA-CV-6441-01A-11D-1683-08	7	69466013	65540503	158	35149	68	2									
ZNF202	7753	broad.mit.edu	37	chr11	123601372	123601372	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgtccgcctctctggtctCagccactggtgacaaagttc	6	13	9	13	1	2	1	1	1	2	0	6	1	3	1	3	2	1	1	3	2	1	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:123601372C>T	uc001pzd.1	-	4	625	c.225G>A	c.(223-225)CTG>CTA	p.L75L	ZNF202_uc001pzc.1_5'UTR|ZNF202_uc001pze.1_Silent_p.L75L|ZNF202_uc001pzf.1_Silent_p.L75L	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	75	SCAN box.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		TCTCTGGTCTCAGCCACTGGT	0.562													19	48					0	0	0	0	T	123601372	T	T	123601372	2	4	191	1	0	0	0	0	0	0	0	1	17830	813	29	2		2	ZNF202	11	123601372	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	54135359	123601372	11405144	159	35150											
ST3GAL4	6484	broad.mit.edu	37	chr11	126276890	126276890	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtgcctccagggtgaggcaGagagcaaggcctctaagctc	9	6	14	12	1	1	2	0	1	1	1	3	3	2	2	3	3	3	3	3	3	2	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:126276890G>A	uc001qds.2	+	4	373	c.154G>A	c.(154-156)GAG>AAG	p.E52K	ST3GAL4_uc001qdt.2_Missense_Mutation_p.E48K|ST3GAL4_uc009zcc.2_5'UTR|ST3GAL4_uc009zcd.2_Missense_Mutation_p.E41K|ST3GAL4_uc001qdu.2_Missense_Mutation_p.E48K|ST3GAL4_uc001qdv.2_Missense_Mutation_p.E52K|ST3GAL4_uc009zce.2_Missense_Mutation_p.E48K|ST3GAL4_uc001qdw.2_Missense_Mutation_p.E41K|ST3GAL4_uc001qdx.1_Missense_Mutation_p.E41K|ST3GAL4_uc001qdy.2_5'UTR|ST3GAL4_uc001qdz.2_5'Flank	NM_006278	NP_006269	Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	52	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		GGGTGAGGCAGAGAGCAAGGC	0.542													15	49					0	0	0	0	A	126276890	A	A	126276890	3	1	191	1	0	0	0	0	1	0	0	0	15283	943	33	2	152	2	ST3GAL4	11	126276890	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	2675518	126276890	8729626	160	35151											
IGSF9B	22997	broad.mit.edu	37	chr11	133790784	133790784	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctggcctgtggcctgaagccGaccttccaggccaccggggc	5	6	14	16	2	0	1	0	1	0	0	1	2	1	1	7	5	1	0	7	5	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr11:133790784G>C	uc001qgx.3	-	18	3067	c.2836C>G	c.(2836-2838)CGG>GGG	p.R946G		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	946	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GCCTGAAGCCGACCTTCCAGG	0.697													14	25					0	0	0	0	C	133790784	C	C	133790784	3	2	191	1	0	0	0	0	1	0	0	0	7645	1057	37	3	1221	3	IGSF9B	11	133790784	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	7513894	133790784	1215732	161	35152											
C12orf4	57102	broad.mit.edu	37	chr12	4643433	4643433	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcataatcgctgagggattCttcttctataaactgagtca	12	14	7	8	1	5	2	2	2	3	0	6	3	5	3	0	1	1	1	0	1	4	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:4643433C>G	uc001qms.2	-	3	302	c.214G>C	c.(214-216)GAA>CAA	p.E72Q	C12orf4_uc001qmt.2_Missense_Mutation_p.E72Q	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	72											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CTGAGGGATTCTTCTTCTATA	0.423													11	32					0	0	0	0	G	4643433	G	G	4643433	3	3	191	1	0	0	0	0	1	0	0	0	1691	922	32	2	1492	2	C12orf4	12	4643433	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08		4643433	129208462	162	35153											
DNM1L	10059	broad.mit.edu	37	chr12	32890803	32890803	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattttttgcctttagtcttCtaaagttccaagtgctttgg	7	19	8	7	0	2	0	0	0	2	0	3	1	3	0	2	1	2	2	2	1	4	9			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:32890803C>G	uc001rld.2	+	15	1762	c.1601C>G	c.(1600-1602)TCT>TGT	p.S534C	DNM1L_uc001rle.2_Intron|DNM1L_uc001rlf.2_Intron|DNM1L_uc010skh.1_Missense_Mutation_p.S600C|DNM1L_uc001rlg.2_Missense_Mutation_p.S600C|DNM1L_uc001rlh.2_Missense_Mutation_p.S587C|DNM1L_uc010ski.1_Missense_Mutation_p.S331C	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	534	Interaction with GSK3B.|B domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CTTTAGTCTTCTAAAGTTCCA	0.433													10	39					0	0	0	0	G	32890803	G	G	32890803	3	3	191	1	0	0	0	0	1	0	0	0	4693	913	32	2	1659	2	DNM1L	12	32890803	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	28247370	32890803	100961092	163	35154											
MLL2	8085	broad.mit.edu	37	chr12	49433388	49433388	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgccgaatcagcagctctcGtagtcgctggcgctatgcaa	8	9	11	13	4	2	0	1	0	1	0	4	1	2	0	1	1	4	6	1	1	4	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:49433388G>A	uc001rta.3	-	32	8059	c.8059C>T	c.(8059-8061)CGA>TGA	p.R2687*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2687	Potential.|LXXLL motif 1.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGCAGCTCTCGTAGTCGCTGG	0.572			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			10	15					0	0	0	0	A	49433388	A	A	49433388	4	1	191	1	0	0	0	0	0	1	0	0	9674	1153	40	1	8646	1	MLL2	12	49433388	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	16542585	49433388	84418507	164	35155											
AQP6	363	broad.mit.edu	37	chr12	50367243	50367243	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcgtaggctcccacatctCtctgccccgtgctgtggcct	3	11	9	18	2	2	0	0	0	2	0	5	0	3	0	5	2	2	3	5	2	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:50367243C>G	uc001rvr.1	+	1	624	c.287C>G	c.(286-288)TCT>TGT	p.S96C	AQP6_uc001rvp.1_Intron|AQP6_uc001rvq.1_RNA	NM_001652	NP_001643	Q13520	AQP6_HUMAN	aquaporin 6	96	Cytoplasmic (Potential).				excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity				0						TCCCACATCTCTCTGCCCCGT	0.677													15	37					0	0	0	0	G	50367243	G	G	50367243	3	3	191	1	0	0	0	0	1	0	0	0	830	913	32	2	289	2	AQP6	12	50367243	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	933855	50367243	83484652	165	35156											
KRT6A	3853	broad.mit.edu	37	chr12	52884660	52884660	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgcatcatacaaggctctCaggaagttgatctcgtctgt	10	12	9	10	1	4	1	2	1	3	0	6	2	4	2	0	2	2	3	0	2	3	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:52884660C>T	uc001sam.2	-	4	1103	c.894G>A	c.(892-894)CTG>CTA	p.L298L		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	298	Coil 1B.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACAAGGCTCTCAGGAAGTTGA	0.488													13	79					0	0	0	0	T	52884660	T	T	52884660	2	4	191	1	0	0	0	0	0	0	0	1	8519	813	29	2		2	KRT6A	12	52884660	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	2517417	52884660	80967235	166	35157											
RARG	5916	broad.mit.edu	37	chr12	53608326	53608338	+	Frame_Shift_Del	DEL	ATAGCTGTCAGGT	-	-																															tctaactgagggctcagctcAtagctgtcaggtgacccttc																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:53608326_53608338delATAGCTGTCAGGT	uc001sce.2	-	6	1013_1025	c.528_540delACCTGACAGCTAT	c.(526-540)TCACCTGACAGCTATfs	p.S176fs	RARG_uc001scd.2_Frame_Shift_Del_p.S165fs|RARG_uc010sob.1_Frame_Shift_Del_p.S154fs|RARG_uc001scf.2_Frame_Shift_Del_p.S176fs|RARG_uc001scg.2_Frame_Shift_Del_p.S104fs|RARG_uc010soc.1_Frame_Shift_Del_p.S55fs|RARG_uc010sod.1_Frame_Shift_Del_p.S213fs	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	176_180	Hinge.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GGCTCAGCTCATAGCTGTCAGGTGACCCTTCTT	0.559													---	---	---								-	53608338	-	-	53608326	7	5	191	1	0	1	0	1	0	0	0	0	13119	224	8	0	844	0	RARG	12	53608326	Frame_Shift_Del	DEL	ATAGCTGTCAGGT	TCGA-CV-6441-01A-11D-1683-08	723666	53608326	80243569	167	35158											
OR6C4	341418	broad.mit.edu	37	chr12	55945429	55945429	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatgagcagcagagtctgcaTacaactagtgttctgctcct	10	12	9	10	0	2	2	0	1	2	1	3	2	3	2	1	0	6	5	1	0	4	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:55945429T>C	uc010spp.1	+	1	419	c.419T>C	c.(418-420)ATA>ACA	p.I140T		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGAGTCTGCATACAACTAGTG	0.468													13	107					0	0	0	0	C	55945429	C	C	55945429	3	2	191	1	0	0	0	0	1	0	0	0	11247	1406	49	5	421	5	OR6C4	12	55945429	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	2337103	55945429	77906466	168	35159											
DPY19L2	283417	broad.mit.edu	37	chr12	64055144	64055144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctggataaagatggaagcGttttattgcattaattataa	14	15	8	4	1	1	1	0	0	1	1	1	3	1	3	0	2	2	2	0	2	7	7	rs140337663		TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:64055144G>A	uc001srp.1	-	4	749	c.568C>T	c.(568-570)CGC>TGC	p.R190C	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	190					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AGATGGAAGCGTTTTATTGCA	0.333													21	69					0	0	0	0	A	64055144	A	A	64055144	3	1	191	1	0	0	0	0	1	0	0	0	4763	1145	40	1	1784	1	DPY19L2	12	64055144	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	8109715	64055144	69796751	169	35160											
RAP1B	5908	broad.mit.edu	37	chr12	69042549	69042549	+	Frame_Shift_Del	DEL	A	-	-																															cttggctcaggaggcgttggAaagtctgctttggtaagtca																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:69042549delA	uc001sub.2	+	2	208	c.45delA	c.(43-45)GGAfs	p.G15fs	RAP1B_uc010ste.1_Intron|RAP1B_uc001suc.2_Frame_Shift_Del_p.G15fs|RAP1B_uc010stf.1_Frame_Shift_Del_p.G15fs|RAP1B_uc010stg.1_Frame_Shift_Del_p.G15fs|RAP1B_uc010sth.1_Frame_Shift_Del_p.G15fs|RAP1B_uc010sti.1_Frame_Shift_Del_p.G15fs	NM_001089704	NP_001083173	P61224	RAP1B_HUMAN	SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;	15	GTP.				blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		GAGGCGTTGGAAAGTCTGCTT	0.363													---	---	---								-	69042549	-	-	69042549	7	5	191	1	0	1	0	1	0	0	0	0	13101	233	9	0	47	0	RAP1B	12	69042549	Frame_Shift_Del	DEL	A	TCGA-CV-6441-01A-11D-1683-08	4987405	69042549	64809346	170	35161											
ANKS1B	56899	broad.mit.edu	37	chr12	99640336	99640336	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cactcctggttgatcttgtgCcaacaatggtatggttttcg	7	15	10	9	1	1	1	0	1	1	0	3	1	2	1	2	3	2	3	2	3	3	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:99640336C>A	uc001tge.1	-	13	2480	c.2063G>T	c.(2062-2064)GGC>GTC	p.G688V	ANKS1B_uc001tgf.1_Missense_Mutation_p.G268V|ANKS1B_uc001tgk.2_5'UTR|ANKS1B_uc009ztt.1_Missense_Mutation_p.G654V	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	688						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TGATCTTGTGCCAACAATGGT	0.433													8	38					0.00307968	0.00314026	1	0	A	99640336	A	A	99640336	3	1	191	1	0	0	0	0	1	0	0	0	689	739	26	4	2027	4	ANKS1B	12	99640336	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	30597787	99640336	34211559	171	35162											
BRAP	8315	broad.mit.edu	37	chr12	112097072	112097072	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatacgtgtgctgcgtttcCtcaaagtgcttataagcatg	9	13	10	9	2	1	0	1	0	0	0	2	0	2	0	1	0	5	5	1	0	4	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:112097072C>T	uc001tsn.3	-	8	1244	c.1050G>A	c.(1048-1050)GAG>GAA	p.E350E	BRAP_uc010syh.1_Silent_p.E171E|BRAP_uc009zvv.2_Silent_p.E320E	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	350	UBP-type.				MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						GCTGCGTTTCCTCAAAGTGCT	0.448													9	69					0	0	0	0	T	112097072	T	T	112097072	2	4	191	1	0	0	0	0	0	0	0	1	1502	680	24	4		4	BRAP	12	112097072	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	12456736	112097072	21754823	172	35163											
TESC	54997	broad.mit.edu	37	chr12	117479755	117479755	+	Frame_Shift_Del	DEL	C	-	-																															acgcccaggccacccaccttCaggaagtcctcgaaggtgat																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:117479755delC	uc001twh.2	-	7	728	c.723delG	c.(721-723)CTGfs	p.L241fs	TESC_uc001twi.2_RNA	NM_017899	NP_060369	Q96BS2	TESC_HUMAN	tescalcin	188					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding				0	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		CACCCACCTTCAGGAAGTCCT	0.632													---	---	---								-	117479755	-	-	117479755	7	5	191	1	0	1	0	1	0	0	0	0	15832	813	29	0	88	0	TESC	12	117479755	Frame_Shift_Del	DEL	C	TCGA-CV-6441-01A-11D-1683-08	5382683	117479755	16372140	173	35164											
WDR66	144406	broad.mit.edu	37	chr12	122413157	122413157	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gttgttgttccagtgtcctgGaggcagcggtttctcttggg	3	15	15	8	1	1	0	0	0	1	0	4	1	3	1	2	4	1	5	2	4	0	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:122413157G>A	uc009zxk.2	+	18	2921	c.2779G>A	c.(2779-2781)GAG>AAG	p.E927K		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	927	WD 9.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CAGTGTCCTGGAGGCAGCGGT	0.527													11	39					0	0	0	0	A	122413157	A	A	122413157	3	1	191	1	0	0	0	0	1	0	0	0	17385	1175	41	2	2904	2	WDR66	12	122413157	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	4933402	122413157	11438738	174	35165											
NCOR2	9612	broad.mit.edu	37	chr12	124812114	124812114	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgagtgcctttctaattaTggcctccagccccatgttgg	7	13	9	12	0	1	1	0	1	1	0	2	1	2	1	5	2	2	1	5	2	2	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:124812114T>C	uc010tay.1	-	47	7210	c.7054A>G	c.(7054-7056)ATA>GTA	p.I2352V	NCOR2_uc010taz.1_Missense_Mutation_p.I2336V|NCOR2_uc010tax.1_Intron	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2353	CORNR box of ID2.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TTTCTAATTATGGCCTCCAGC	0.488													16	23					0	0	0	0	C	124812114	C	C	124812114	3	2	191	1	0	0	0	0	1	0	0	0	10290	1464	51	5	532	5	NCOR2	12	124812114	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	2398957	124812114	9039781	175	35166											
ZNF10	7556	broad.mit.edu	37	chr12	133732548	133732548	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacaggtgataaatcctacaAatgccctgataatgacaact	16	9	6	10	0	0	3	0	3	0	0	1	3	1	3	2	1	3	0	2	1	6	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr12:133732548A>T	uc009zzb.2	+	5	1163	c.716A>T	c.(715-717)AAA>ATA	p.K239I	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.K239I	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	239				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AAATCCTACAAATGCCCTGAT	0.373													27	48					0	0	0	0	T	133732548	T	T	133732548	3	4	191	1	0	0	0	0	1	0	0	0	17779	14	1	5	730	5	ZNF10	12	133732548	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	8920434	133732548	119347	176	35167											
MAB21L1	4081	broad.mit.edu	37	chr13	36050182	36050182	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aactactttgcagacttcccGgatagttttggcaatggcag	10	12	10	9	1	0	1	0	0	0	1	1	2	1	2	1	3	3	4	1	3	4	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:36050182G>T	uc001uvc.2	-	1	651	c.94C>A	c.(94-96)CGG>AGG	p.R32R	NBEA_uc001uvb.2_Intron|NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_5'Flank|NBEA_uc010teg.1_5'Flank	NM_005584	NP_005575	Q13394	MB211_HUMAN	mab-21-like protein 1	32					anatomical structure morphogenesis	nucleus				ovary(2)	2		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		CAGACTTCCCGGATAGTTTTG	0.512													18	73					1.37657e-19	1.55113e-19	1	0	T	36050182	T	T	36050182	2	4	191	1	0	0	0	0	0	0	0	1	9192	1115	39	3		3	MAB21L1	13	36050182	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08		36050182	79119696	177	35168											
SLITRK6	84189	broad.mit.edu	37	chr13	86369500	86369500	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaaatattccactagatCagacttcattaaactgtgaa	16	12	6	7	0	2	4	2	2	0	2	3	4	3	4	1	0	1	0	1	0	6	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:86369500C>A	uc001vll.1	-	2	1603	c.1144G>T	c.(1144-1146)GAT>TAT	p.D382Y	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	382	Extracellular (Potential).|LRR 6.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCCACTAGATCAGACTTCATT	0.378													32	46					1.06801e-11	1.17368e-11	1	0	A	86369500	A	A	86369500	3	1	191	1	0	0	0	0	1	0	0	0	14811	826	29	2	1385	2	SLITRK6	13	86369500	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	50319318	86369500	28800378	178	35169											
ATP11A	23250	broad.mit.edu	37	chr13	113439521	113439521	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagccacctccgggcgcaGaggcctacatcccacagaga	10	3	13	15	2	0	2	0	0	0	2	2	4	2	3	5	3	2	1	5	3	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:113439521G>C	uc001vsi.3	+	2	200	c.112G>C	c.(112-114)GAG>CAG	p.E38Q	ATP11A_uc001vsj.3_Missense_Mutation_p.E38Q|ATP11A_uc001vsm.1_5'UTR	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	38	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TCCGGGCGCAGAGGCCTACAT	0.557											OREG0003855	type=REGULATORY REGION|Gene=ATP11A|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	17	74					0	0	0	0	C	113439521	C	C	113439521	3	2	191	1	0	0	0	0	1	0	0	0	1121	943	33	2	118	2	ATP11A	13	113439521	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	27070021	113439521	1730357	179	35170											
ATP11A	23250	broad.mit.edu	37	chr13	113464990	113464990	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgaaccagtgtcctgttCatttcattcagcacggcaag	10	11	8	12	1	3	1	3	1	0	0	4	1	4	1	3	1	2	3	3	1	2	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr13:113464990C>A	uc001vsi.3	+	5	479	c.391C>A	c.(391-393)CAT>AAT	p.H131N	ATP11A_uc001vsj.3_Missense_Mutation_p.H131N|ATP11A_uc001vsm.1_Missense_Mutation_p.H7N	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	131	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GTGTCCTGTTCATTTCATTCA	0.323													18	124					8.00594e-06	8.38332e-06	1	0	A	113464990	A	A	113464990	3	1	191	1	0	0	0	0	1	0	0	0	1121	826	29	2	409	2	ATP11A	13	113464990	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	25469	113464990	1704888	180	35171											
MDGA2	161357	broad.mit.edu	37	chr14	47426600	47426600	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	taacaagaaagctgcatctcCcagctccagcttcatttatg	12	11	6	12	0	2	1	1	0	1	1	4	1	3	1	2	0	5	4	2	0	4	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:47426600C>T	uc001wwj.3	-	9	2055	c.1859G>A	c.(1858-1860)GGG>GAG	p.G620E	MDGA2_uc001wwi.3_Missense_Mutation_p.G391E|MDGA2_uc010ani.2_Missense_Mutation_p.G180E	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	620	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GCTGCATCTCCCAGCTCCAGC	0.358													17	35					0	0	0	0	T	47426600	T	T	47426600	3	4	191	1	0	0	0	0	1	0	0	0	9460	623	22	4	1047	4	MDGA2	14	47426600	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08		47426600	59922940	181	35172											
NID2	22795	broad.mit.edu	37	chr14	52535538	52535538	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggggattcgccagcttcaCcacggctgagctttcgtcgt	6	10	12	13	4	1	1	1	1	0	0	4	2	1	2	2	3	2	3	2	3	0	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:52535538C>A	uc001wzo.2	-	1	409	c.175G>T	c.(175-177)GTG>TTG	p.V59L	NID2_uc010tqs.1_Missense_Mutation_p.V59L|NID2_uc010tqt.1_Missense_Mutation_p.V59L|NID2_uc001wzp.2_Missense_Mutation_p.V59L	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	59						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GCCAGCTTCACCACGGCTGAG	0.637													22	37					2.48779e-11	2.71475e-11	1	0	A	52535538	A	A	52535538	3	1	191	1	0	0	0	0	1	0	0	0	10469	507	18	4	4040	4	NID2	14	52535538	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	5108938	52535538	54814002	182	35173											
MLH3	27030	broad.mit.edu	37	chr14	75485569	75485569	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtggtctatgtcagctaacGgcagcatagaaggtctcccg	10	9	12	10	2	3	1	1	0	2	1	4	1	3	1	1	3	3	3	1	3	4	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:75485569G>T	uc001xrd.1	-	12	4421	c.4205C>A	c.(4204-4206)CCG>CAG	p.P1402Q	MLH3_uc001xre.1_Missense_Mutation_p.P1378Q	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	1402					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		GTCAGCTAACGGCAGCATAGA	0.468								MMR					25	38					6.12954e-19	6.8819e-19	1	0	T	75485569	T	T	75485569	3	4	191	1	0	0	0	0	1	0	0	0	9671	1116	39	3	164	3	MLH3	14	75485569	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	22950031	75485569	31863971	183	35174											
AHNAK2	113146	broad.mit.edu	37	chr14	105412107	105412107	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaactgggcatctgcaacttGggcaggtgccctttgaggcc	8	9	13	11	0	1	1	0	1	1	0	1	1	1	1	2	4	4	3	2	4	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr14:105412107G>C	uc010axc.1	-	7	9801	c.9681C>G	c.(9679-9681)CCC>CCG	p.P3227P	AHNAK2_uc001ypx.2_Silent_p.P3127P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3227						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTGCAACTTGGGCAGGTGCC	0.617													34	389					0	0	0	0	C	105412107	C	C	105412107	2	2	191	1	0	0	0	0	0	0	0	1	415	1335	47	4		4	AHNAK2	14	105412107	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	29926538	105412107	1937433	184	35175											
SLC12A6	9990	broad.mit.edu	37	chr15	34538068	34538068	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctttcacagcatcaccgaaCctgggaaagaaataggagtg	14	7	10	10	1	2	1	2	0	0	1	2	4	2	3	3	2	2	1	3	2	4	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:34538068C>A	uc001zhw.2	-	13	1814	c.1650G>T	c.(1648-1650)AAG>AAT	p.K550N	SLC12A6_uc001zhv.2_Missense_Mutation_p.K499N|SLC12A6_uc001zhx.2_Missense_Mutation_p.K535N|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.K491N|SLC12A6_uc001zib.2_Missense_Mutation_p.K541N|SLC12A6_uc001zic.2_Missense_Mutation_p.K550N|SLC12A6_uc010bau.2_Missense_Mutation_p.K550N|SLC12A6_uc001zid.2_Missense_Mutation_p.K491N|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Missense_Mutation_p.K362N	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	550	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CATCACCGAACCTGGGAAAGA	0.373													7	13					0.00198382	0.0020362	1	0	A	34538068	A	A	34538068	3	1	191	1	0	0	0	0	1	0	0	0	14452	521	18	4	1854	4	SLC12A6	15	34538068	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08		34538068	67993324	185	35176											
FBN1	2200	broad.mit.edu	37	chr15	48892392	48892392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atagacagtgatcgtcactgCagctacctccattcatacag	12	10	7	12	1	2	2	2	1	0	1	4	2	3	2	2	0	4	2	2	0	3	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:48892392C>T	uc001zwx.1	-	5	714	c.386G>A	c.(385-387)TGC>TAC	p.C129Y		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	129	EGF-like 2.		C -> Y (in MFS; severe neonatal).		heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ATCGTCACTGCAGCTACCTCC	0.378													52	21					0	0	0	0	T	48892392	T	T	48892392	3	4	191	1	0	0	0	0	1	0	0	0	5734	710	25	4	8477	4	FBN1	15	48892392	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	14354324	48892392	53639000	186	35177											
KIAA1370	56204	broad.mit.edu	37	chr15	52903845	52903845	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcgcaggatcatttagatCaattccctctgtggtgggcc	9	12	10	10	1	3	1	2	0	1	1	5	2	4	2	2	3	0	1	2	3	3	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:52903845C>T	uc002acg.3	-	4	484	c.331G>A	c.(331-333)GAT>AAT	p.D111N	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Missense_Mutation_p.D23N|KIAA1370_uc010ugf.1_Missense_Mutation_p.D118N	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	111											0				all cancers(107;0.0803)		TCATTTAGATCAATTCCCTCT	0.428													14	39					0	0	0	0	T	52903845	T	T	52903845	3	4	191	1	0	0	0	0	1	0	0	0	8265	826	29	2	2939	2	KIAA1370	15	52903845	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	4011453	52903845	49627547	187	35178											
UNC13C	440279	broad.mit.edu	37	chr15	54914565	54914565	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtcagatatctgttcaTgtggacatcactgccacccc	8	11	10	12	0	4	1	3	0	1	1	4	2	4	2	3	2	1	1	3	2	1	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:54914565T>C	uc002ack.2	+	29	6147	c.6147T>C	c.(6145-6147)CAT>CAC	p.H2049H	UNC13C_uc002acm.2_5'UTR	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	2049	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TATCTGTTCATGTGGACATCA	0.428													61	18					0	0	0	0	C	54914565	C	C	54914565	2	2	191	1	0	0	0	0	0	0	0	1	17054	1461	51	5		5	UNC13C	15	54914565	Silent	SNP	T	TCGA-CV-6441-01A-11D-1683-08	2010720	54914565	47616827	188	35179											
CILP	8483	broad.mit.edu	37	chr15	65490839	65490839	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccagttcagccatggggtcTtcaccaaccacttcccccag	8	9	7	17	0	3	0	2	0	1	0	5	0	5	0	6	2	2	1	6	2	1	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:65490839T>C	uc002aon.2	-	9	1966	c.1785A>G	c.(1783-1785)GAA>GAG	p.E595E		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	595					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CCATGGGGTCTTCACCAACCA	0.522													29	57					0	0	0	0	C	65490839	C	C	65490839	2	2	191	1	0	0	0	0	0	0	0	1	3444	1606	56	5		5	CILP	15	65490839	Silent	SNP	T	TCGA-CV-6441-01A-11D-1683-08	10576274	65490839	37040553	189	35180											
CLK3	1198	broad.mit.edu	37	chr15	74922109	74922109	+	Nonsense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgacctgatgaggaggatgtTagaatttgaccctgcccagc	10	10	12	9	0	0	5	0	4	0	1	0	7	0	7	3	2	2	1	3	2	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:74922109T>G	uc010uln.1	+	13	2263	c.1802T>G	c.(1801-1803)TTA>TGA	p.L601*	CLK3_uc002ayg.3_Nonsense_Mutation_p.L453*|CLK3_uc002ayh.3_Nonsense_Mutation_p.L232*|CLK3_uc002ayj.3_Nonsense_Mutation_p.L430*|CLK3_uc002ayk.3_Nonsense_Mutation_p.L380*|CLK3_uc002ayl.3_Nonsense_Mutation_p.L286*	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	601	Protein kinase.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						AGGAGGATGTTAGAATTTGAC	0.607													22	5					0	0	0	0	G	74922109	G	G	74922109	4	3	191	1	0	0	0	0	0	1	0	0	3553	1764	61	5	1852	5	CLK3	15	74922109	Nonsense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	9431270	74922109	27609283	190	35181											
NR2F2	7026	broad.mit.edu	37	chr15	96875642	96875642	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagggctgcaagagcttctTcaagcgcagcgtgcggagga	9	6	16	10	4	2	1	1	0	1	1	2	4	2	3	0	3	5	4	0	3	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:96875642T>G	uc010uri.1	+	1	1532	c.308T>G	c.(307-309)TTC>TGC	p.F103C	NR2F2_uc002btp.2_Intron|NR2F2_uc010urj.1_5'Flank|MIR1469_hsa-mir-1469|MI0007074_5'Flank|NR2F2_uc010urk.1_5'Flank	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	103	Nuclear receptor.				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			AAGAGCTTCTTCAAGCGCAGC	0.622													6	11					0	0	0	0	G	96875642	G	G	96875642	3	3	191	1	0	0	0	0	1	0	0	0	10682	1783	62	5	357	5	NR2F2	15	96875642	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	21953533	96875642	5655750	191	35182											
ALDH1A3	220	broad.mit.edu	37	chr15	101445832	101445832	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccatggaagacaaggggctCttcatcaaacccactgtctt	11	9	9	12	0	4	1	2	0	2	1	4	2	4	2	2	3	1	1	2	3	3	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr15:101445832C>G	uc002bwn.3	+	10	1277	c.1173C>G	c.(1171-1173)CTC>CTG	p.L391L	ALDH1A3_uc010bpb.2_Silent_p.L284L|uc002bwo.1_Intron	NM_000693	NP_000684	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1A3	391					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	ACAAGGGGCTCTTCATCAAAC	0.537													4	26					0	0	0	0	G	101445832	G	G	101445832	2	3	191	1	0	0	0	0	0	0	0	1	492	900	32	2		2	ALDH1A3	15	101445832	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	4570190	101445832	1085560	192	35183											
E4F1	1877	broad.mit.edu	37	chr16	2273707	2273707	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgggcgagggtgcagttgcGgcggtggcggcggccttggc	2	6	23	10	6	0	0	0	0	0	0	0	1	0	0	1	8	2	2	1	8	0	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:2273707G>A	uc002cpm.2	+	1	141	c.93G>A	c.(91-93)GCG>GCA	p.A31A	E4F1_uc010bsi.2_Silent_p.A31A|E4F1_uc010bsj.2_Silent_p.A31A	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	31					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GTGCAGTTGCGGCGGTGGCGG	0.751													7	2					0	0	0	0	A	2273707	A	A	2273707	2	1	191	1	0	0	0	0	0	0	0	1	4896	1103	39	1		1	E4F1	16	2273707	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08		2273707	88081046	193	35184											
ATXN2L	11273	broad.mit.edu	37	chr16	28844640	28844640	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccccccggtgggcctcatCaagggagaagacaaagatga	13	4	13	11	1	2	4	2	1	0	3	2	5	2	4	4	3	1	0	4	3	3	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:28844640C>T	uc002drc.2	+	14	2088	c.1920C>T	c.(1918-1920)ATC>ATT	p.I640I	uc010vct.1_Intron|ATXN2L_uc010byl.1_Silent_p.I616I|ATXN2L_uc002drb.2_Silent_p.I640I|ATXN2L_uc002dqy.2_Silent_p.I640I|ATXN2L_uc002dra.2_Silent_p.I640I|ATXN2L_uc002dqz.2_Silent_p.I640I|ATXN2L_uc010vdb.1_Silent_p.I646I|ATXN2L_uc002dre.2_Silent_p.I640I|ATXN2L_uc002drf.2_Silent_p.I49I|ATXN2L_uc002drg.2_5'Flank	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	640						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TGGGCCTCATCAAGGGAGAAG	0.622													18	46					0	0	0	0	T	28844640	T	T	28844640	2	4	191	1	0	0	0	0	0	0	0	1	1214	816	29	2		2	ATXN2L	16	28844640	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	26570933	28844640	61510113	194	35185											
TBX6	6911	broad.mit.edu	37	chr16	30100461	30100461	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cccatccaccggaatcacatCcagaagaaacaagtagcggg	15	4	9	13	2	1	2	1	0	0	2	3	3	3	3	4	2	2	1	4	2	5	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:30100461C>G	uc010veh.1	-	4	484	c.424G>C	c.(424-426)GAT>CAT	p.D142H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TBX6_uc002dwk.1_Missense_Mutation_p.D142H	NM_004608	NP_004599	O95947	TBX6_HUMAN	T-box 6	142	T-box.				anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GGAATCACATCCAGAAGAAAC	0.662													17	72					0	0	0	0	G	30100461	G	G	30100461	3	3	191	1	0	0	0	0	1	0	0	0	15728	855	30	2	910	2	TBX6	16	30100461	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	1255821	30100461	60254292	195	35186											
CNGB1	1258	broad.mit.edu	37	chr16	57973358	57973358	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaactggcagcctcggcctCagcctcaggctcctccttgg	5	9	11	16	1	2	1	2	1	0	0	5	1	4	1	5	4	3	2	5	4	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:57973358C>T	uc002emt.2	-	16	1413	c.1348G>A	c.(1348-1350)GAG>AAG	p.E450K	CNGB1_uc010cdh.2_Missense_Mutation_p.E444K	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	450	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GCCTCGGCCTCAGCCTCAGGc	0.328													7	26					0	0	0	0	T	57973358	T	T	57973358	3	4	191	1	0	0	0	0	1	0	0	0	3615	835	29	2	2479	2	CNGB1	16	57973358	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	27872897	57973358	32381395	196	35187											
CENPN	55839	broad.mit.edu	37	chr16	81061821	81061821	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaatgggagcatcttggctGagagggaagaacccctccga	12	7	13	9	1	1	2	0	1	1	2	2	6	2	4	3	3	2	2	3	3	4	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:81061821G>A	uc002ffx.2	+	10	1646	c.856G>A	c.(856-858)GAG>AAG	p.E286K	CENPN_uc010vnl.1_Missense_Mutation_p.E252K|CENPN_uc010vnm.1_Missense_Mutation_p.E266K|CENPN_uc002ffy.3_Missense_Mutation_p.E286K	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	286					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						CATCTTGGCTGAGAGGGAAGA	0.403													11	49					0	0	0	0	A	81061821	A	A	81061821	3	1	191	1	0	0	0	0	1	0	0	0	3253	1291	45	2	978	2	CENPN	16	81061821	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	23088463	81061821	9292932	197	35188											
PKD1L2	114780	broad.mit.edu	37	chr16	81183305	81183305	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggaattacccaagtccatCttttgctcagctgggtcctt	7	14	9	11	0	2	0	1	0	1	0	4	1	4	1	3	2	3	2	3	2	3	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr16:81183305C>G	uc002fgh.1	-	28	4743	c.4743G>C	c.(4741-4743)AAG>AAC	p.K1581N	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1581	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCAAGTCCATCTTTTGCTCAG	0.557													5	19					0	0	0	0	G	81183305	G	G	81183305	3	3	191	1	0	0	0	0	1	0	0	0	12020	912	32	2	2699	2	PKD1L2	16	81183305	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	121484	81183305	9171448	198	35189											
DNAH2	146754	broad.mit.edu	37	chr17	7736073	7736073	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttcagctcgccaaaacaaCgtgagcaatgtgcaaagtgt	13	9	9	10	2	2	1	1	1	1	0	3	1	2	1	1	0	5	3	1	0	5	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:7736073C>T	uc002giu.1	+	82	12917	c.12903C>T	c.(12901-12903)AAC>AAT	p.N4301N		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4301					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCCAAAACAACGTGAGCAATG	0.557													172	43					0	0	0	0	T	7736073	T	T	7736073	2	4	191	1	0	0	0	0	0	0	0	1	4624	550	19	1		1	DNAH2	17	7736073	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08		7736073	73459137	199	35190											
MYH2	4620	broad.mit.edu	37	chr17	10433049	10433049	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cctgccatctcttctgtgagGtttttcacctacaaaggtga	8	14	8	11	0	3	2	1	2	2	0	4	2	3	2	3	2	2	1	3	2	2	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:10433049G>T	uc010coi.2	-	24	3077	c.2949C>A	c.(2947-2949)AAC>AAA	p.N983K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.N983K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	983	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTTCTGTGAGGTTTTTCACCT	0.473													90	87					2.68873e-43	3.09702e-43	1	0	T	10433049	T	T	10433049	3	4	191	1	0	0	0	0	1	0	0	0	10088	1252	44	4	2944	4	MYH2	17	10433049	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	2696976	10433049	70762161	200	35191											
NCOR1	9611	broad.mit.edu	37	chr17	16068406	16068406	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgaaggtgaagcattttGatcatctccacatggttgcc	9	15	9	8	0	2	3	1	3	1	0	3	3	2	3	2	2	2	2	2	2	2	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:16068406G>C	uc002gpo.2	-	5	745	c.505C>G	c.(505-507)CAA>GAA	p.Q169E	NCOR1_uc002gpn.2_Missense_Mutation_p.Q169E|NCOR1_uc002gpp.1_Missense_Mutation_p.Q60E|NCOR1_uc002gpr.2_Missense_Mutation_p.Q60E|NCOR1_uc002gps.1_Missense_Mutation_p.Q169E|NCOR1_uc010coz.1_Translation_Start_Site|NCOR1_uc010cpb.1_Missense_Mutation_p.Q169E|NCOR1_uc010cpa.1_Missense_Mutation_p.Q169E|NCOR1_uc002gpu.2_Missense_Mutation_p.Q169E	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	169	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GAAGCATTTTGATCATCTCCA	0.393													10	76					0	0	0	0	C	16068406	C	C	16068406	3	2	191	1	0	0	0	0	1	0	0	0	10289	1299	45	2	6985	2	NCOR1	17	16068406	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	5635357	16068406	65126804	201	35192											
NCOR1	9611	broad.mit.edu	37	chr17	16068472	16068472	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgtttgcctccgaatgctgGatcctttagagaataaaacc	12	12	8	9	1	0	1	0	0	0	1	2	4	2	2	4	1	3	2	4	1	5	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:16068472G>A	uc002gpo.2	-	5	679	c.439C>T	c.(439-441)CCA>TCA	p.P147S	NCOR1_uc002gpn.2_Missense_Mutation_p.P147S|NCOR1_uc002gpp.1_Missense_Mutation_p.P38S|NCOR1_uc002gpr.2_Missense_Mutation_p.P38S|NCOR1_uc002gps.1_Missense_Mutation_p.P147S|NCOR1_uc010coz.1_5'UTR|NCOR1_uc010cpb.1_Missense_Mutation_p.P147S|NCOR1_uc010cpa.1_Missense_Mutation_p.P147S|NCOR1_uc002gpu.2_Missense_Mutation_p.P147S	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	147	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CCGAATGCTGGATCCTTTAGA	0.393													8	72					0	0	0	0	A	16068472	A	A	16068472	3	1	191	1	0	0	0	0	1	0	0	0	10289	1174	41	2	7051	2	NCOR1	17	16068472	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	66	16068472	65126738	202	35193											
MYO15A	51168	broad.mit.edu	37	chr17	18062990	18062990	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacgtgctttgtaacctcctGaaggtcagtccagccaactt	9	11	9	12	1	1	1	1	1	0	0	3	2	3	1	4	1	4	2	4	1	3	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:18062990G>A	uc010vxh.1	+	54	9638	c.9300G>A	c.(9298-9300)CTG>CTA	p.L3100L	MYO15A_uc010vxi.1_Silent_p.L364L|MYO15A_uc010vxk.1_Intron|MYO15A_uc010vxl.1_Silent_p.L89L|MYO15A_uc002gsl.2_Silent_p.L22L|MYO15A_uc010vxm.1_Silent_p.L22L|MYO15A_uc002gsm.1_5'Flank|MYO15A_uc010cpv.2_5'Flank	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3100	Tail.|MyTH4 2.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GTAACCTCCTGAAGGTCAGTC	0.532													8	28					0	0	0	0	A	18062990	A	A	18062990	2	1	191	1	0	0	0	0	0	0	0	1	10116	1277	45	2		2	MYO15A	17	18062990	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	1994518	18062990	63132220	203	35194											
CDK12	51755	broad.mit.edu	37	chr17	37627593	37627593	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcacagggaacaagagactCtaaacccatagcactgaaag	18	4	9	10	0	1	2	0	1	1	1	1	4	1	3	1	1	4	2	1	1	6	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:37627593C>G	uc010cvv.2	+	2	2094	c.1508C>G	c.(1507-1509)TCT>TGT	p.S503C	CDK12_uc010wef.1_Missense_Mutation_p.S502C|CDK12_uc002hrw.3_Missense_Mutation_p.S503C	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	503					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						ACAAGAGACTCTAAACCCATA	0.428										TCGA Ovarian(9;0.13)			26	111					0	0	0	0	G	37627593	G	G	37627593	3	3	191	1	0	0	0	0	1	0	0	0	3143	913	32	2	1514	2	CDK12	17	37627593	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	19564603	37627593	43567617	204	35195											
NMT1	4836	broad.mit.edu	37	chr17	43159057	43159057	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagccaaaaagaagaaaaaGaaacaaaaaaagaagaaaga	29	0	9	3	0	0	6	0	0	0	6	0	7	0	7	1	1	2	0	1	1	11	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:43159057G>C	uc002ihz.2	+	2	195	c.177G>C	c.(175-177)AAG>AAC	p.K59N	NMT1_uc010dac.1_Intron|NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	59	Poly-Lys.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				agaagaaaaagaaacaaaaaa	0.343													5	28					0	0	0	0	C	43159057	C	C	43159057	3	2	191	1	0	0	0	0	1	0	0	0	10557	933	33	2	183	2	NMT1	17	43159057	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	5531464	43159057	38036153	205	35196											
ABCA5	23461	broad.mit.edu	37	chr17	67287394	67287394	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtccacaaagaatattcatCaatgtactctttcctgttcc	12	14	4	11	0	3	1	2	0	1	1	6	1	6	1	3	0	1	2	3	0	5	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:67287394C>T	uc002jif.2	-	11	2787	c.1569G>A	c.(1567-1569)TTG>TTA	p.L523L	ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Silent_p.L523L|ABCA5_uc002jih.2_Silent_p.L523L|ABCA5_uc010dfe.2_Silent_p.L523L	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	523	ABC transporter 1.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					GAATATTCATCAATGTACTCT	0.338													10	46					0	0	0	0	T	67287394	T	T	67287394	2	4	191	1	0	0	0	0	0	0	0	1	35	825	29	2		2	ABCA5	17	67287394	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	24128337	67287394	13907816	206	35197											
KIF19	124602	broad.mit.edu	37	chr17	72348997	72348997	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattaccccagcaggaacctCactgaccccagattctgacc	12	7	6	16	0	2	3	1	2	1	1	2	4	2	4	6	1	3	1	6	1	3	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:72348997C>G	uc002jkm.3	+	15	2156	c.2018C>G	c.(2017-2019)TCA>TGA	p.S673*		NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	673					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GCAGGAACCTCACTGACCCCA	0.567													17	91					0	0	0	0	G	72348997	G	G	72348997	4	3	191	1	0	0	0	0	0	1	0	0	8321	838	29	2	2076	2	KIF19	17	72348997	Nonsense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	5061603	72348997	8846213	207	35198											
AFMID	125061	broad.mit.edu	37	chr17	76187113	76187113	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgggagcagaggaagccttGaggacctactcacagatagg	12	6	14	9	0	1	3	1	1	0	2	1	6	1	6	2	4	3	1	2	4	3	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:76187113G>C	uc002jva.3	+	2	141	c.126G>C	c.(124-126)TTG>TTC	p.L42F	AFMID_uc002juy.3_RNA|AFMID_uc010dhj.2_Missense_Mutation_p.L42F|AFMID_uc002jvb.3_Missense_Mutation_p.L42F|AFMID_uc002juz.3_Missense_Mutation_p.L42F	NM_001010982	NP_001010982	Q63HM1	AFMID_HUMAN	arylformamidase isoform 1	42						cytosol|nucleus	arylformamidase activity			large_intestine(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			AGGAAGCCTTGAGGACCTACT	0.542													4	12					0	0	0	0	C	76187113	C	C	76187113	3	2	191	1	0	0	0	0	1	0	0	0	362	1281	45	2	132	2	AFMID	17	76187113	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	3838116	76187113	5008097	208	35199											
CCDC40	55036	broad.mit.edu	37	chr17	78032313	78032313	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcggctctgcagactgagAtggagaacttggccctgcat	8	9	14	10	1	1	3	0	1	1	3	1	5	1	3	1	4	3	3	1	4	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:78032313A>G	uc010dht.2	+	8	1207	c.1180A>G	c.(1180-1182)ATG>GTG	p.M394V	CCDC40_uc010wub.1_Missense_Mutation_p.M394V|CCDC40_uc002jxm.3_Missense_Mutation_p.M177V	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	394	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCAGACTGAGATGGAGAACTT	0.602													8	37					0	0	0	0	G	78032313	G	G	78032313	3	3	191	1	0	0	0	0	1	0	0	0	2825	333	12	5	1210	5	CCDC40	17	78032313	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	1845200	78032313	3162897	209	35200											
NPLOC4	55666	broad.mit.edu	37	chr17	79534533	79534533	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagatgaggtattctgagaCaaataggtggccaagctatg	14	9	12	6	0	1	3	0	2	1	2	1	4	1	3	1	3	1	2	1	3	5	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:79534533C>A	uc002kat.3	-	15	1658	c.1476G>T	c.(1474-1476)TTG>TTT	p.L492F	NPLOC4_uc002kau.3_Missense_Mutation_p.L492F|NPLOC4_uc010wur.1_Missense_Mutation_p.L331F|NPLOC4_uc010dic.2_5'Flank|NPLOC4_uc002kas.2_Missense_Mutation_p.C16F	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	492					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TATTCTGAGACAAATAGGTGG	0.478													6	9					0.00116845	0.00120327	1	0	A	79534533	A	A	79534533	3	1	191	1	0	0	0	0	1	0	0	0	10640	477	17	4	362	4	NPLOC4	17	79534533	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	1502220	79534533	1660677	210	35201											
HGS	9146	broad.mit.edu	37	chr17	79667588	79667588	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccggacccaccgccagcccCgcttactcatcctaccagcc	7	5	7	22	3	1	0	1	0	0	0	2	1	2	1	9	1	4	1	9	1	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:79667588C>T	uc002kbg.2	+	19	2051	c.1974C>T	c.(1972-1974)CCC>CCT	p.P658P	MRPL12_uc002kbh.1_5'Flank|SLC25A10_uc010wut.1_5'Flank	NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	658	Interaction with NF2.|Gln-rich.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			CCGCCAGCCCCGCTTACTCAT	0.587													54	7					0	0	0	0	T	79667588	T	T	79667588	2	4	191	1	0	0	0	0	0	0	0	1	7126	639	23	1		1	HGS	17	79667588	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	133055	79667588	1527622	211	35202											
THOC4	10189	broad.mit.edu	37	chr17	79847182	79847182	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcacagccgccttcttcagCgttccaaattcagcaaagag	11	9	8	13	2	3	1	2	0	1	1	4	1	4	1	3	0	4	3	3	0	2	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr17:79847182C>T	uc002kbu.2	-	3	420	c.414G>A	c.(412-414)ACG>ACA	p.T138T	ANAPC11_uc002kbv.1_5'Flank|ANAPC11_uc002kbw.1_5'Flank|ANAPC11_uc002kbx.1_5'Flank|ANAPC11_uc002kby.1_5'Flank|ANAPC11_uc002kbz.1_5'Flank|ANAPC11_uc002kca.1_5'Flank|ANAPC11_uc002kcb.1_5'Flank|ANAPC11_uc002kcc.1_5'Flank	NM_005782	NP_005773	Q86V81	THOC4_HUMAN	THO complex 4	131	RRM.|Ala/Arg/Gly-rich.				intronless viral mRNA export from host nucleus|mRNA 3'-end processing|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear speck|transcription export complex	nucleotide binding|protein binding|RNA binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CCTTCTTCAGCGTTCCAAATT	0.547													47	15					0	0	0	0	T	79847182	T	T	79847182	2	4	191	1	0	0	0	0	0	0	0	1	15933	755	27	1		1	THOC4	17	79847182	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	179594	79847182	1348028	212	35203											
TGIF1	7050	broad.mit.edu	37	chr18	3456381	3456381	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcatctggcagtgagactGaggatgaggacagcatggac	12	6	15	8	0	1	3	0	3	1	1	1	7	1	6	0	4	2	3	0	4	0	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:3456381G>C	uc002klz.2	+	2	820	c.433G>C	c.(433-435)GAG>CAG	p.E145Q	TGIF1_uc002klu.2_5'UTR|TGIF1_uc002klv.2_Missense_Mutation_p.E30Q|TGIF1_uc002klx.2_5'UTR|TGIF1_uc002klw.2_Missense_Mutation_p.E16Q|TGIF1_uc010dkm.1_Missense_Mutation_p.E16Q|TGIF1_uc002kly.2_Missense_Mutation_p.E16Q|TGIF1_uc002kma.2_5'UTR|TGIF1_uc002kmb.2_5'UTR|TGIF1_uc002kmc.2_5'UTR	NM_170695	NP_733796	Q15583	TGIF1_HUMAN	TG-interacting factor isoform a	145					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Esophageal squamous(4;0.0859)	Colorectal(8;0.0104)				CAGTGAGACTGAGGATGAGGA	0.502													6	563					0	0	0	0	C	3456381	C	C	3456381	3	2	191	1	0	0	0	0	1	0	0	0	15891	1291	45	2	521	2	TGIF1	18	3456381	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08		3456381	74620867	213	35204											
POTEC	388468	broad.mit.edu	37	chr18	14542916	14542916	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagtgcccacgttgctcGtgccgctccccctgcagcag	6	7	11	17	3	0	1	0	0	0	1	2	1	1	1	4	0	5	5	4	0	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:14542916G>T	uc010dln.2	-	1	684	c.230C>A	c.(229-231)ACG>AAG	p.T77K	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	77										skin(3)	3						CACGTTGCTCGTGCCGCTCCC	0.577													9	210					6.31663e-08	6.72764e-08	1	0	T	14542916	T	T	14542916	3	4	191	1	0	0	0	0	1	0	0	0	12317	1145	40	3	1442	3	POTEC	18	14542916	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	11086535	14542916	63534332	214	35205											
KIAA1012	22878	broad.mit.edu	37	chr18	29450923	29450923	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggaaatcttgaattatcTgagtaactgttcaaacagta	15	13	8	5	0	3	2	1	2	2	0	3	3	3	3	0	1	2	3	0	1	6	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:29450923T>C	uc002kxc.3	-	15	2587	c.2223A>G	c.(2221-2223)TCA>TCG	p.S741S	KIAA1012_uc002kxb.3_Silent_p.S687S|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	741					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TTGAATTATCTGAGTAACTGT	0.328													9	9					0	0	0	0	C	29450923	C	C	29450923	2	2	191	1	0	0	0	0	0	0	0	1	8243	1567	55	5		5	KIAA1012	18	29450923	Silent	SNP	T	TCGA-CV-6441-01A-11D-1683-08	14908007	29450923	48626325	215	35206											
CXXC1	30827	broad.mit.edu	37	chr18	47812911	47812911	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccatccatggccctcacctCtgcactcccgacagtaccac	8	8	5	20	1	2	0	1	0	1	0	5	1	5	0	6	1	2	2	6	1	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:47812911C>G	uc002leq.3	-	3	954	c.221G>C	c.(220-222)AGA>ACA	p.R74T	CXXC1_uc002lep.3_5'UTR|CXXC1_uc002ler.3_Missense_Mutation_p.R74T|CXXC1_uc010doy.2_Missense_Mutation_p.R74T|CXXC1_uc002les.2_Missense_Mutation_p.R74T	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	74	PHD-type.				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCCCTCACCTCTGCACTCCCG	0.592													20	43					0	0	0	0	G	47812911	G	G	47812911	3	3	191	1	0	0	0	0	1	0	0	0	4114	913	32	2	1813	2	CXXC1	18	47812911	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	18361988	47812911	30264337	216	35207											
TXNL1	9352	broad.mit.edu	37	chr18	54285302	54285302	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgtcaaatccatgctcaTcactttcattaagacattca	13	14	4	10	0	5	1	5	0	0	1	6	1	6	1	1	0	1	2	1	0	2	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:54285302T>G	uc002lgg.2	-	4	674	c.425A>C	c.(424-426)GAT>GCT	p.D142A	TXNL1_uc010xdz.1_RNA|TXNL1_uc002lgh.2_RNA|TXNL1_uc002lgi.2_Missense_Mutation_p.D142A|TXNL1_uc002lgj.1_Missense_Mutation_p.D142A	NM_004786	NP_004777	O43396	TXNL1_HUMAN	thioredoxin-like 1	142	PITH.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		TCCATGCTCATCACTTTCATT	0.353													17	31					0	0	0	0	G	54285302	G	G	54285302	3	3	191	1	0	0	0	0	1	0	0	0	16872	1435	50	5	464	5	TXNL1	18	54285302	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	6472391	54285302	23791946	217	35208											
ZNF516	9658	broad.mit.edu	37	chr18	74154474	74154474	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttacgctcgaactggctcttGcagaaggagcactggaccgc	9	8	12	12	3	1	1	0	0	1	1	2	4	1	3	1	3	4	4	1	3	3	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr18:74154474G>A	uc010dqx.1	-	2	772	c.537C>T	c.(535-537)TGC>TGT	p.C179C	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	179	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		ACTGGCTCTTGCAGAAGGAGC	0.672													4	19					0	0	0	0	A	74154474	A	A	74154474	2	1	191	1	0	0	0	0	0	0	0	1	18027	1311	46	4		4	ZNF516	18	74154474	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	19869172	74154474	3922774	218	35209											
NCLN	56926	broad.mit.edu	37	chr19	3192652	3192652	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccgccgtgccccaggacgtCgtccgggtgagcgtctgccc	3	6	15	17	6	1	1	0	1	1	0	3	2	2	2	6	2	3	0	6	2	0	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:3192652C>T	uc002lxi.2	+	2	523	c.369C>T	c.(367-369)GTC>GTT	p.V123V	NCLN_uc002lxh.1_RNA	NM_020170	NP_064555	Q969V3	NCLN_HUMAN	nicalin precursor	123	Lumenal (Potential).				proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGGACGTCGTCCGGGTGA	0.592													7	15					0	0	0	0	T	3192652	T	T	3192652	2	4	191	1	0	0	0	0	0	0	0	1	10281	871	31	1		1	NCLN	19	3192652	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08		3192652	55936331	219	35210											
DAPK3	1613	broad.mit.edu	37	chr19	3964692	3964692	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgccgtccaggatctgcttGaggaactgggtggcctcgtc	6	9	14	12	3	1	1	0	1	1	0	4	3	2	3	3	4	2	1	3	4	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:3964692G>C	uc002lzc.1	-	2	453	c.360C>G	c.(358-360)CTC>CTG	p.L120L	DAPK3_uc002lzb.1_5'Flank|DAPK3_uc002lzd.1_Silent_p.L120L	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	120	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GGATCTGCTTGAGGAACTGGG	0.632													27	66					0	0	0	0	C	3964692	C	C	3964692	2	2	191	1	0	0	0	0	0	0	0	1	4254	1277	45	2		2	DAPK3	19	3964692	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	772040	3964692	55164291	220	35211											
PPAN	56342	broad.mit.edu	37	chr19	10221801	10221801	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcttcccgggatggtgggcGaggccggggccggggccgcc	2	4	22	13	5	0	0	0	0	0	0	1	2	1	1	5	9	0	1	5	9	0	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:10221801G>A	uc002mmz.1	+	12	1488	c.1382G>A	c.(1381-1383)CGA>CAA	p.R461Q	PPAN-P2RY11_uc010xla.1_Intron|PPAN-P2RY11_uc002mna.2_Intron|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mnb.1_Missense_Mutation_p.R408Q	NM_020230	NP_064615	Q9NQ55	SSF1_HUMAN	peter pan homolog	461					RNA splicing	nucleolus	protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GATGGTGGGCGAGGCCGGGGC	0.697													4	7					0	0	0	0	A	10221801	A	A	10221801	3	1	191	1	0	0	0	0	1	0	0	0	12343	1058	37	1		1	PPAN	19	10221801	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	6257109	10221801	48907182	221	35212											
LDLR	3949	broad.mit.edu	37	chr19	11233896	11233896	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagacatccaccgtcaggctAaaggtcagctccacagccgt	11	6	10	14	2	2	1	2	0	0	1	4	2	4	1	4	2	2	2	4	2	2	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:11233896A>G	uc002mqk.3	+	15	2355	c.2187A>G	c.(2185-2187)CTA>CTG	p.L729L	LDLR_uc010xlk.1_Silent_p.L729L|LDLR_uc010xll.1_Silent_p.L688L|LDLR_uc010xlm.1_Silent_p.L582L|LDLR_uc010xln.1_Silent_p.L551L|LDLR_uc010xlo.1_Silent_p.L561L	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	729	Clustered O-linked oligosaccharides.|Extracellular (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CCGTCAGGCTAAAGGTCAGCT	0.612													14	47					0	0	0	0	G	11233896	G	G	11233896	2	3	191	1	0	0	0	0	0	0	0	1	8744	349	13	5		5	LDLR	19	11233896	Silent	SNP	A	TCGA-CV-6441-01A-11D-1683-08	1012095	11233896	47895087	222	35213											
CCDC105	126402	broad.mit.edu	37	chr19	15132719	15132719	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccaactcccggaggctgcGcgcctcgcacaggtaaaccc	9	4	10	18	4	0	0	0	0	0	0	2	1	1	1	4	3	3	3	4	3	3	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:15132719G>A	uc002nae.2	+	6	1338	c.1239G>A	c.(1237-1239)GCG>GCA	p.A413A		NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	413					microtubule cytoskeleton organization	microtubule				ovary(1)	1						CGGAGGCTGCGCGCCTCGCAC	0.617													26	16					0	0	0	0	A	15132719	A	A	15132719	2	1	191	1	0	0	0	0	0	0	0	1	2752	1074	38	1		1	CCDC105	19	15132719	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	3898823	15132719	43996264	223	35214											
CASP14	23581	broad.mit.edu	37	chr19	15164426	15164426	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcgaaagcaccatgaaaaGagaccccactgccgaggtat	15	6	9	11	2	0	2	0	1	0	1	1	5	0	2	4	1	2	2	4	1	4	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:15164426G>C	uc010dzv.1	+	3	469	c.161G>C	c.(160-162)AGA>ACA	p.R54T	CASP14_uc002naf.2_Missense_Mutation_p.R54T	NM_012114	NP_036246	P31944	CASPE_HUMAN	caspase 14 precursor	54					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity			skin(2)|ovary(1)|lung(1)	4						ACCATGAAAAGAGACCCCACT	0.537													17	60					0	0	0	0	C	15164426	C	C	15164426	3	2	191	1	0	0	0	0	1	0	0	0	2682	942	33	2	167	2	CASP14	19	15164426	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	31707	15164426	43964557	224	35215											
CPAMD8	27151	broad.mit.edu	37	chr19	17086829	17086829	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacctgggcaggagtcagccGgaacccagacctgagcaggt	10	4	14	13	1	1	2	1	1	0	1	1	4	1	4	4	4	3	2	4	4	1	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:17086829G>A	uc002nfb.2	-	16	2064	c.2032C>T	c.(2032-2034)CGG>TGG	p.R678W		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	631						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GGAGTCAGCCGGAACCCAGAC	0.602													12	11					0	0	0	0	A	17086829	A	A	17086829	3	1	191	1	0	0	0	0	1	0	0	0	3810	1115	39	1	3874	1	CPAMD8	19	17086829	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	1922403	17086829	42042154	225	35216											
SF4	57794	broad.mit.edu	37	chr19	19431288	19431288	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacctgcaacatcccggttGtccatcttgagactcatcca	9	12	6	14	1	2	1	1	1	1	1	5	2	5	1	4	1	3	2	4	1	2	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:19431288G>A	uc002nmh.2	-	1	20	c.18C>T	c.(16-18)GAC>GAT	p.D6D	SF4_uc002nmi.2_5'UTR|SF4_uc002nmj.2_5'UTR|SF4_uc010xqr.1_RNA|SF4_uc010xqs.1_RNA|KIAA0892_uc002nmk.3_5'Flank	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	6					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						CATCCCGGTTGTCCATCTTGA	0.632													24	41					0	0	0	0	A	19431288	A	A	19431288	2	1	191	1	0	0	0	0	0	0	0	1	14220	1368	48	4		4	SF4	19	19431288	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	2344459	19431288	39697695	226	35217											
ZNF257	113835	broad.mit.edu	37	chr19	22271115	22271115	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttgcatgctttcacaacTaactcgacataagagaattc	14	13	5	9	1	1	1	1	0	0	1	3	3	1	1	0	0	4	2	0	0	4	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:22271115T>A	uc010ecx.2	+	4	732	c.563T>A	c.(562-564)CTA>CAA	p.L188Q	ZNF257_uc010ecy.2_Missense_Mutation_p.L156Q	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	188	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTTTCACAACTAACTCGACAT	0.338													4	18					0	0	0	0	A	22271115	A	A	22271115	3	1	191	1	0	0	0	0	1	0	0	0	17867	1522	53	5	577	5	ZNF257	19	22271115	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	2839827	22271115	36857868	227	35218											
ZNF780A	284323	broad.mit.edu	37	chr19	40582009	40582009	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttctaaaataaaaggcctCaatgccaagagttgtactta	16	12	6	7	0	2	1	1	0	1	1	2	1	2	1	2	1	2	2	2	1	8	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:40582009C>G	uc002omy.2	-	6	565	c.340G>C	c.(340-342)GAG>CAG	p.E114Q	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.E114Q|ZNF780A_uc010xvh.1_Missense_Mutation_p.E115Q	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TAAAAGGCCTCAATGCCAAGA	0.328													35	17					0	0	0	0	G	40582009	G	G	40582009	3	3	191	1	0	0	0	0	1	0	0	0	18219	835	29	2	1716	2	ZNF780A	19	40582009	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	18310894	40582009	18546974	228	35219											
GRIK5	2901	broad.mit.edu	37	chr19	42557775	42557775	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggatggttgtgaccaccagGgtcttgttggccagtgtctg	6	12	15	8	0	2	1	0	1	2	0	2	2	2	2	3	4	0	2	3	4	0	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:42557775G>A	uc002osj.1	-	10	1283	c.1248C>T	c.(1246-1248)ACC>ACT	p.T416T	GRIK5_uc010eib.1_Silent_p.T335T	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	416	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TGACCACCAGGGTCTTGTTGG	0.622													11	32					0	0	0	0	A	42557775	A	A	42557775	2	1	191	1	0	0	0	0	0	0	0	1	6816	1219	43	4		4	GRIK5	19	42557775	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	1975766	42557775	16571208	229	35220											
PSG8	440533	broad.mit.edu	37	chr19	43269720	43269720	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgtgtgcagggaggggctGagaggagccccatggtctct	6	8	18	9	0	1	1	0	1	1	1	2	4	1	3	2	5	2	3	2	5	0	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:43269720G>C	uc002ouo.2	-	1	112	c.14C>G	c.(13-15)TCA>TGA	p.S5*	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_5'UTR|PSG8_uc002ouh.2_Nonsense_Mutation_p.S5*|PSG8_uc010ein.2_Nonsense_Mutation_p.S5*|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Intron|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	5						extracellular region					0		Prostate(69;0.00899)				GGGAGGGGCTGAGAGGAGCCC	0.592													18	62					0	0	0	0	C	43269720	C	C	43269720	4	2	191	1	0	0	0	0	0	1	0	0	12723	1294	45	2	1307	2	PSG8	19	43269720	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	711945	43269720	15859263	230	35221											
MARK4	57787	broad.mit.edu	37	chr19	45783855	45783855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtggggaccggggcgcccCagggctggccctggcacggg	3	3	22	13	3	0	0	0	0	0	0	0	1	0	1	4	9	0	2	4	9	0	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:45783855C>T	uc002pbb.1	+	12	1144	c.1139C>T	c.(1138-1140)CCA>CTA	p.P380L	MARK4_uc002paz.1_3'UTR|MARK4_uc002pba.1_Missense_Mutation_p.P380L|MARK4_uc002pbc.1_Missense_Mutation_p.P246L			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	380					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CGGGGCGCCCCAGGGCTGGCC	0.677													11	49					0	0	0	0	T	45783855	T	T	45783855	3	4	191	1	0	0	0	0	1	0	0	0	9368	594	21	4	1185	4	MARK4	19	45783855	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	2514135	45783855	13345128	231	35222											
ZC3H4	23211	broad.mit.edu	37	chr19	47575952	47575952	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcatcctcggcacctgcttCtgcatcatcggccaacatct	7	11	6	17	2	4	0	2	0	2	0	7	0	5	0	3	2	3	3	3	2	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:47575952C>T	uc002pga.3	-	12	1497	c.1459G>A	c.(1459-1461)GAA>AAA	p.E487K	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	487							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GCACCTGCTTCTGCATCATCG	0.587													8	15					0	0	0	0	T	47575952	T	T	47575952	3	4	191	1	0	0	0	0	1	0	0	0	17637	922	32	2	2468	2	ZC3H4	19	47575952	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	1792097	47575952	11553031	232	35223											
VRK3	51231	broad.mit.edu	37	chr19	50496192	50496192	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acatactcattctcatggagGaactccagggcatccagctg	11	9	9	12	0	2	0	2	0	1	0	5	2	4	2	2	3	3	2	2	3	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:50496192G>C	uc002prg.2	-	10	986	c.888C>G	c.(886-888)TTC>TTG	p.F296L	VRK3_uc002prh.1_Missense_Mutation_p.F296L|VRK3_uc002pri.1_Missense_Mutation_p.F246L|VRK3_uc010ens.2_Missense_Mutation_p.F296L|VRK3_uc010ybl.1_Missense_Mutation_p.F246L|VRK3_uc010ybm.1_Missense_Mutation_p.F65L|VRK3_uc002prj.1_Missense_Mutation_p.F246L|VRK3_uc002prk.1_Missense_Mutation_p.F296L|VRK3_uc010ent.1_Missense_Mutation_p.F52L|VRK3_uc002prl.2_Missense_Mutation_p.F296L|VRK3_uc010ybn.1_Missense_Mutation_p.S274C	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	296	Protein kinase.					nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		TCTCATGGAGGAACTCCAGGG	0.522													33	94					0	0	0	0	C	50496192	C	C	50496192	3	2	191	1	0	0	0	0	1	0	0	0	17289	1165	41	2	556	2	VRK3	19	50496192	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	2920240	50496192	8632791	233	35224											
SIGLEC7	27036	broad.mit.edu	37	chr19	51649129	51649129	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcatccacagctctggggAacagctcatctctttcagtc	9	10	8	14	0	4	0	2	0	2	0	7	1	5	1	1	2	4	3	1	2	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:51649129A>C	uc002pvv.1	+	4	847	c.778A>C	c.(778-780)AAC>CAC	p.N260H	SIGLEC7_uc002pvw.1_Missense_Mutation_p.N167H|SIGLEC7_uc010eoq.1_Intron|SIGLEC7_uc010eor.1_Intron	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	260	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		AGCTCTGGGGAACAGCTCATC	0.517													19	83					0	0	0	0	C	51649129	C	C	51649129	3	2	191	1	0	0	0	0	1	0	0	0	14378	246	9	5	792	5	SIGLEC7	19	51649129	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	1152937	51649129	7479854	234	35225											
KIR3DL1	3811	broad.mit.edu	37	chr19	55378031	55378031	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acgcacagttggatcactgcGttttcatacagagaaaaatc	14	10	8	9	2	2	1	2	0	0	1	3	3	2	2	0	1	2	3	0	1	3	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:55378031G>A	uc002qhl.3	+	9	1276	c.1213G>A	c.(1213-1215)GTT>ATT	p.V405I	KIR3DL2_uc010esh.2_Missense_Mutation_p.V388I|KIR3DL2_uc002qho.3_Missense_Mutation_p.V405I			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	405	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GGATCACTGCGTTTTCATACA	0.512													56	135					0	0	0	0	A	55378031	A	A	55378031	3	1	191	1	0	0	0	0	1	0	0	0	8359	1145	40	1		1	KIR3DL1	19	55378031	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	3728902	55378031	3750952	235	35226											
NLRP13	126204	broad.mit.edu	37	chr19	56413454	56413454	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggcctcacacaggaacttGactccctcgtctctcaggct	9	9	8	15	1	3	1	2	1	1	0	6	2	4	2	2	3	1	1	2	3	2	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:56413454G>C	uc010ygg.1	-	9	2761	c.2736C>G	c.(2734-2736)GTC>GTG	p.V912V		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	912	LRR 4.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ACAGGAACTTGACTCCCTCGT	0.552													14	57					0	0	0	0	C	56413454	C	C	56413454	2	2	191	1	0	0	0	0	0	0	0	1	10529	1277	45	2		2	NLRP13	19	56413454	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	1035423	56413454	2715529	236	35227											
NLRP8	126205	broad.mit.edu	37	chr19	56481960	56481960	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttggactgatcttggcaataAtcttcaaggtaacgggcatc	11	12	10	8	1	3	1	1	1	2	0	4	2	3	2	0	4	1	3	0	4	4	5	rs143689901		TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr19:56481960A>C	uc002qmh.2	+	6	2503	c.2432A>C	c.(2431-2433)AAT>ACT	p.N811T	NLRP8_uc010etg.2_Missense_Mutation_p.N811T	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	811						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTTGGCAATAATCTTCAAGGT	0.483													23	177					0	0	0	0	C	56481960	C	C	56481960	3	2	191	1	0	0	0	0	1	0	0	0	10537	101	4	5	2454	5	NLRP8	19	56481960	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	68506	56481960	2647023	237	35228											
ACSS1	84532	broad.mit.edu	37	chr20	24993469	24993469	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggcgtcctcaatctctgcGgtccccagccggtggccact	5	9	11	16	3	2	0	1	0	1	0	5	0	4	0	5	4	2	0	5	4	1	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:24993469G>A	uc002wub.2	-	11	2564	c.1686C>T	c.(1684-1686)ACC>ACT	p.T562T	ACSS1_uc002wuc.2_Silent_p.T560T|ACSS1_uc010gdc.2_Silent_p.T357T|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Silent_p.T479T	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	562					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CAATCTCTGCGGTCCCCAGCC	0.597													38	34					0	0	0	0	A	24993469	A	A	24993469	2	1	191	1	0	0	0	0	0	0	0	1	188	1103	39	1		1	ACSS1	20	24993469	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08		24993469	38032051	238	35229											
KIF3B	9371	broad.mit.edu	37	chr20	30898796	30898796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agggagaagagggtgaggagGaaggggatgataaggatgat	15	5	21	0	0	0	5	0	3	0	2	0	10	0	9	0	7	0	0	0	7	3	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:30898796G>A	uc002wxq.2	+	2	1383	c.1216G>A	c.(1216-1218)GAA>AAA	p.E406K	KIF3B_uc010ztv.1_Intron|KIF3B_uc010ztw.1_Intron	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	406	Poly-Glu.|Potential.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			gggtgaggaggaaggggaTGA	0.418													8	14					0	0	0	0	A	30898796	A	A	30898796	3	1	191	1	0	0	0	0	1	0	0	0	8340	1175	41	2	1218	2	KIF3B	20	30898796	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	5905327	30898796	32126724	239	35230											
SAMHD1	25939	broad.mit.edu	37	chr20	35532577	35532577	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacatccactataaaatcttCagccttcagtttcacgtcta	12	14	3	12	1	5	0	3	0	2	0	6	0	6	0	2	0	2	1	2	0	5	7			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:35532577C>A	uc002xgh.1	-	13	1616	c.1486G>T	c.(1486-1488)GAA>TAA	p.E496*	SAMHD1_uc010gft.1_RNA	NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	496					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				ATAAAATCTTCAGCCTTCAGT	0.353													22	108					1.10923e-09	1.19782e-09	1	0	A	35532577	A	A	35532577	4	1	191	1	0	0	0	0	0	1	0	0	13893	835	29	2	410	2	SAMHD1	20	35532577	Nonsense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	4633781	35532577	27492943	240	35231											
PTPRT	11122	broad.mit.edu	37	chr20	41306573	41306573	+	Frame_Shift_Del	DEL	G	-	-																															cccccctcacctggtcgtgtGaggagcactcggatctcata																										TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:41306573delG	uc002xkg.2	-	7	1270	c.1086delC	c.(1084-1086)CTCfs	p.L362fs	PTPRT_uc010ggj.2_Frame_Shift_Del_p.L362fs	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	362	Extracellular (Potential).|Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTGGTCGTGTGAGGAGCACTC	0.567													---	---	---								-	41306573	-	-	41306573	7	5	191	1	0	1	0	1	0	0	0	0	12877	1277	45	0	3400	0	PTPRT	20	41306573	Frame_Shift_Del	DEL	G	TCGA-CV-6441-01A-11D-1683-08	5773996	41306573	21718947	241	35232											
ZNF334	55713	broad.mit.edu	37	chr20	45140723	45140723	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatccctgagcaacttacctGaaattttttcattttcatgt	11	17	4	9	0	2	2	2	2	0	0	3	2	3	2	2	0	3	1	2	0	4	6			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:45140723G>T	uc002xsc.2	-	2	203	c.19C>A	c.(19-21)CAG>AAG	p.Q7K	ZNF334_uc002xsd.2_5'UTR|ZNF334_uc010ghl.2_5'UTR	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				CAACTTACCTGAAATTTTTTC	0.378													20	26					7.87624e-14	8.77961e-14	1	0	T	45140723	T	T	45140723	3	4	191	1	0	0	0	0	1	0	0	0	17918	1299	45	2	2039	2	ZNF334	20	45140723	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	3834150	45140723	17884797	242	35233											
ZNFX1	57169	broad.mit.edu	37	chr20	47887747	47887747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacatggagaacactctggCgatccattttggagctacaa	12	10	10	9	1	1	1	0	0	1	1	2	4	2	2	1	3	4	2	1	3	4	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:47887747C>T	uc002xui.2	-	3	849	c.602G>A	c.(601-603)CGC>CAC	p.R201H		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	201							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AACACTCTGGCGATCCATTTT	0.453													57	65					0	0	0	0	T	47887747	T	T	47887747	3	4	191	1	0	0	0	0	1	0	0	0	18272	768	27	1	5202	1	ZNFX1	20	47887747	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	2747024	47887747	15137773	243	35234											
KCNB1	3745	broad.mit.edu	37	chr20	47990164	47990164	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actagagtgctggctggcatCagggctggggttggcctcca	6	9	16	10	0	1	1	1	0	0	1	2	1	2	1	2	6	1	5	2	6	1	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:47990164C>G	uc002xur.1	-	2	2097	c.1933G>C	c.(1933-1935)GAT>CAT	p.D645H	KCNB1_uc002xus.1_Missense_Mutation_p.D645H	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	645	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGGCTGGCATCAGGGCTGGGG	0.567													7	57					0	0	0	0	G	47990164	G	G	47990164	3	3	191	1	0	0	0	0	1	0	0	0	8051	826	29	2	647	2	KCNB1	20	47990164	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	102417	47990164	15035356	244	35235											
LAMA5	3911	broad.mit.edu	37	chr20	60884793	60884793	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcaggcccccgaggtacaGaggggctggggcaccagctg	8	3	18	12	1	0	1	0	0	0	1	0	2	0	1	3	7	2	5	3	7	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr20:60884793G>C	uc002ycq.2	-	79	10994	c.10927C>G	c.(10927-10929)CTG>GTG	p.L3643V		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3643	Laminin G-like 5.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCGAGGTACAGAGGGGCTGGG	0.607													10	12					0	0	0	0	C	60884793	C	C	60884793	3	2	191	1	0	0	0	0	1	0	0	0	8649	933	33	2	168	2	LAMA5	20	60884793	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	12894629	60884793	2140727	245	35236											
RWDD2B	10069	broad.mit.edu	37	chr21	30380432	30380432	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagtctgctgggatctactCaataatactgatctaataga	13	13	8	7	0	4	3	1	2	3	1	4	4	4	4	0	1	3	1	0	1	6	5			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr21:30380432C>G	uc002yms.2	-	4	462	c.375G>C	c.(373-375)TTG>TTC	p.L125F	RWDD2B_uc002ymt.2_Missense_Mutation_p.L96F|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Missense_Mutation_p.L45F	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	125	RWD.										0						GGGATCTACTCAATAATACTG	0.358													13	35					0	0	0	0	G	30380432	G	G	30380432	3	3	191	1	0	0	0	0	1	0	0	0	13821	825	29	2	592	2	RWDD2B	21	30380432	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08		30380432	17749463	246	35237											
MICAL3	57553	broad.mit.edu	37	chr22	18387474	18387474	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcgtagatcatgtatggtGaatggccagagatgcaagac	12	9	12	8	1	1	4	1	1	0	3	2	5	1	4	2	2	1	3	2	2	4	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:18387474G>A	uc002zng.3	-	3	749	c.396C>T	c.(394-396)TTC>TTT	p.F132F	MICAL3_uc011agl.1_Silent_p.F132F|MICAL3_uc002znh.2_Silent_p.F132F|MICAL3_uc002znj.1_5'Flank|MICAL3_uc002znk.1_Silent_p.F132F|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Silent_p.F132F|MICAL3_uc011agm.1_Silent_p.F132F	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	132						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CATGTATGGTGAATGGCCAGA	0.483													32	91					0	0	0	0	A	18387474	A	A	18387474	2	1	191	1	0	0	0	0	0	0	0	1	9624	1281	45	2		2	MICAL3	22	18387474	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08		18387474	32917092	247	35238											
MICAL3	57553	broad.mit.edu	37	chr22	18387600	18387600	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggggccagccccaatgatGagacactgaaaaacacagct	15	4	10	12	0	0	3	0	3	0	1	0	4	0	3	3	2	3	1	3	2	3	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:18387600G>A	uc002zng.3	-	3	623	c.270C>T	c.(268-270)CTC>CTT	p.L90L	MICAL3_uc011agl.1_Silent_p.L90L|MICAL3_uc002znh.2_Silent_p.L90L|MICAL3_uc002znj.1_5'Flank|MICAL3_uc002znk.1_Silent_p.L90L|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Silent_p.L90L|MICAL3_uc011agm.1_Silent_p.L90L	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	90	FAD (Potential).					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CCCCAATGATGAGACACTGAA	0.507													4	20					0	0	0	0	A	18387600	A	A	18387600	2	1	191	1	0	0	0	0	0	0	0	1	9624	1277	45	2		2	MICAL3	22	18387600	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08	126	18387600	32916966	248	35239											
MICAL3	57553	broad.mit.edu	37	chr22	18389542	18389542	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaccggtcaaagaggacatGagctgggttcatggtctcat	12	9	12	8	1	3	2	3	1	1	1	4	3	3	3	1	4	2	2	1	4	2	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:18389542G>C	uc002zng.3	-	2	390	c.37C>G	c.(37-39)CAT>GAT	p.H13D	MICAL3_uc011agl.1_Missense_Mutation_p.H13D|MICAL3_uc002znh.2_Missense_Mutation_p.H13D|MICAL3_uc002znk.1_Missense_Mutation_p.H13D|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Missense_Mutation_p.H13D|MICAL3_uc011agm.1_Missense_Mutation_p.H13D	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	13						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		AAGAGGACATGAGCTGGGTTC	0.577													18	63					0	0	0	0	C	18389542	C	C	18389542	3	2	191	1	0	0	0	0	1	0	0	0	9624	1290	45	2	6832	2	MICAL3	22	18389542	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	1942	18389542	32915024	249	35240											
C22orf15	150248	broad.mit.edu	37	chr22	24106898	24106898	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccattacccagagctggCaggtgagtgtcagggtacag	10	8	14	9	0	1	3	1	2	0	1	1	3	1	3	2	3	3	3	2	3	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:24106898C>T	uc011aja.1	+	4	609	c.323C>T	c.(322-324)GCA>GTA	p.A108V	C22orf15_uc002zxv.1_3'UTR|C22orf15_uc002zxu.2_Missense_Mutation_p.A113V	NM_182520	NP_872326	Q8WYQ4	CV015_HUMAN	hypothetical protein LOC150248	108											0		Medulloblastoma(6;6.27e-05)|all_neural(6;0.00518)				CCAGAGCTGGCAGGTGAGTGT	0.587													11	25					0	0	0	0	T	24106898	T	T	24106898	3	4	191	1	0	0	0	0	1	0	0	0	2146	710	25	4	337	4	C22orf15	22	24106898	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	5717356	24106898	27197668	250	35241											
EIF3L	51386	broad.mit.edu	37	chr22	38270460	38270460	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcctggtcgggcttctcCgcctgcactccctgttagga	4	11	11	15	2	2	0	1	0	1	0	5	1	3	1	4	3	2	3	4	3	1	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:38270460C>T	uc003auf.2	+	9	922	c.835C>T	c.(835-837)CGC>TGC	p.R279C	EIF3L_uc003aue.1_Missense_Mutation_p.R279C|EIF3L_uc011ann.1_Missense_Mutation_p.R231C|EIF3L_uc003aug.2_Missense_Mutation_p.R171C|EIF3L_uc003auh.2_Missense_Mutation_p.R12C	NM_016091	NP_057175	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3	279						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1						CGGGCTTCTCCGCCTGCACTC	0.547													44	19					0	0	0	0	T	38270460	T	T	38270460	3	4	191	1	0	0	0	0	1	0	0	0	5046	652	23	1	869	1	EIF3L	22	38270460	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	14163562	38270460	13034106	251	35242											
ST13	6767	broad.mit.edu	37	chr22	41240914	41240914	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaccttctttatcaatttCtgccaaagtcgagaaaatga	14	12	5	10	1	3	2	1	1	2	1	4	3	3	2	2	0	1	0	2	0	5	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:41240914C>T	uc003aze.2	-	4	388	c.245_splice	c.e4-1	p.E82_splice	ST13_uc011aow.1_Splice_Site_p.E72_splice	NM_003932	NP_003923	P50502	F10A1_HUMAN	heat shock 70kD protein binding protein								protein binding, bridging				0						TTATCAATTTCTGCCAAAGTC	0.388													6	15					0	0	0	0	T	41240914	T	T	41240914	5	4	191	1	0	0	0	0	0	0	1	0	15276	927	32	2	901	2	ST13	22	41240914	Splice_Site	SNP	C	TCGA-CV-6441-01A-11D-1683-08	2970454	41240914	10063652	252	35243											
MPPED1	758	broad.mit.edu	37	chr22	43898630	43898630	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttacatgtctttggccacatCcacgaaggtcagtacgtagc	10	11	9	11	2	2	0	1	0	1	0	3	1	3	0	2	2	3	2	2	2	4	4			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:43898630C>A	uc011apv.1	+	6	1078	c.855C>A	c.(853-855)ATC>ATA	p.I285I	MPPED1_uc011apw.1_Silent_p.I179I|MPPED1_uc011apx.1_Silent_p.I127I|MPPED1_uc011apy.1_Silent_p.I285I|MPPED1_uc011apz.1_Silent_p.I318I	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	285							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				TTGGCCACATCCACGAAGGTC	0.612													14	29					6.31663e-08	6.72764e-08	1	0	A	43898630	A	A	43898630	2	1	191	1	0	0	0	0	0	0	0	1	9794	845	30	2		2	MPPED1	22	43898630	Silent	SNP	C	TCGA-CV-6441-01A-11D-1683-08	2657716	43898630	7405936	253	35244											
PLXNB2	23654	broad.mit.edu	37	chr22	50724681	50724681	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgaggaagatgttgcctcGtctaaggaggagctggatgg	9	9	17	6	2	1	2	0	1	1	1	2	6	1	6	1	5	2	2	1	5	2	2			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chr22:50724681G>A	uc003bkv.3	-	9	1904	c.1798C>T	c.(1798-1800)CGA>TGA	p.R600*		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	600	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ATGTTGCCTCGTCTAAGGAGG	0.647													59	20					0	0	0	0	A	50724681	A	A	50724681	4	1	191	1	0	0	0	0	0	1	0	0	12179	1153	40	1	3834	1	PLXNB2	22	50724681	Nonsense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	6826051	50724681	579885	254	35245											
IL3RA	3563	broad.mit.edu	37	chrX	1471251	1471251	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtgtcttcactacaaaacGgatgctcagggaacacgtat	13	9	10	9	2	3	0	2	0	1	0	3	3	3	2	0	2	4	2	0	2	5	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:1471251G>A	uc004cps.2	+	6	817	c.468G>A	c.(466-468)ACG>ACA	p.T156T	IL3RA_uc011mhd.1_Silent_p.T78T	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	156	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ACTACAAAACGGATGCTCAGG	0.602													86	151					0	0	0	0	A	1471251	A	A	1471251	2	1	191	1	0	0	0	0	0	0	0	1	7734	1103	39	1		1	IL3RA	23	1471251	Silent	SNP	G	TCGA-CV-6441-01A-11D-1683-08		1471251	153799309	255	35246											
ZMAT1	84460	broad.mit.edu	37	chrX	101159303	101159303	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgttcattccaaatggcgTctgtgaataaaaaagggaag	14	10	10	7	1	2	1	1	1	1	0	3	2	3	2	2	2	0	1	2	2	6	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:101159303T>C	uc011mrl.1	-	3	433	c.122A>G	c.(121-123)GAC>GGC	p.D41G	ZMAT1_uc004ein.2_5'UTR|ZMAT1_uc011mrm.1_5'UTR	NM_001011657	NP_001011657	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 1	Error:Variant_position_missing_in_A7MD47_after_alignment						nucleus	zinc ion binding			ovary(1)	1						CCAAATGGCGTCTGTGAATAA	0.299													8	15					0	0	0	0	C	101159303	C	C	101159303	3	2	191	1	0	0	0	0	1	0	0	0	17758	1681	58	5	1814	5	ZMAT1	23	101159303	Missense_Mutation	SNP	T	TCGA-CV-6441-01A-11D-1683-08	99688052	101159303	54111257	256	35247											
MAGEA4	4103	broad.mit.edu	37	chrX	151092296	151092296	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctggcaccctggaggaaGtgcctgctgctgagtcagca	7	8	13	13	0	1	1	1	1	0	0	2	3	2	3	3	3	4	4	3	3	1	0			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:151092296G>A	uc004fez.2	+	3	316	c.160G>A	c.(160-162)GTG>ATG	p.V54M	MAGEA4_uc004ffa.2_Missense_Mutation_p.V54M|MAGEA4_uc004ffb.2_Missense_Mutation_p.V54M|MAGEA4_uc004ffc.2_Missense_Mutation_p.V54M|MAGEA4_uc004ffd.2_Missense_Mutation_p.V54M	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	54							protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGGAGGAAGTGCCTGCTGC	0.627													40	10					0	0	0	0	A	151092296	A	A	151092296	3	1	191	1	0	0	0	0	1	0	0	0	9219	1029	36	4	162	4	MAGEA4	23	151092296	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08	49932993	151092296	4178264	257	35248											
FLNA	2316	broad.mit.edu	37	chrX	153596026	153596026	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgggggatgcccagccAgtcatccgcctgctgcatgg	6	8	13	14	1	1	0	1	0	0	0	2	1	2	1	5	3	5	2	5	3	1	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrX:153596026A>T	uc004fkk.2	-	4	952	c.703T>A	c.(703-705)TGG>AGG	p.W235R	FLNA_uc010nuu.1_Missense_Mutation_p.W235R	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	235	CH 2.|Actin-binding.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATGCCCAGCCAGTCATCCGCC	0.657													60	23					0	0	0	0	T	153596026	T	T	153596026	3	4	191	1	0	0	0	0	1	0	0	0	5965	188	7	5	7420	5	FLNA	23	153596026	Missense_Mutation	SNP	A	TCGA-CV-6441-01A-11D-1683-08	2503730	153596026	1674534	258	35249											
TSPY2	64591	broad.mit.edu	37	chrY	6115622	6115622	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggaagaagagaagcatcGtgttcatctctgcaagatca	13	9	12	7	1	3	3	2	0	1	3	5	5	3	4	0	2	2	3	0	2	4	1			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrY:6115622G>C	uc004fqr.1	+	3	630	c.584G>C	c.(583-585)CGT>CCT	p.R195P	TSPY2_uc004fqs.1_Missense_Mutation_p.R195P	NM_022573	NP_072095	A6NKD2	TSPY2_HUMAN	testis specific protein, Y-linked 2	195					cell differentiation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus					0						GAGAAGCATCGTGTTCATCTC	0.443													4	92					0	0	0	0	C	6115622	C	C	6115622	3	2	191	1	0	0	0	0	1	0	0	0	16725	1145	40	3	594	3	TSPY2	24	6115622	Missense_Mutation	SNP	G	TCGA-CV-6441-01A-11D-1683-08		6115622	53257944	259	35250											
TMSB4Y	9087	broad.mit.edu	37	chrY	15816245	15816245	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aaacctggtatggctgagatCgagaaattcgataagtcgaa	15	9	11	6	3	0	2	0	1	0	2	3	6	0	2	1	2	1	2	1	2	5	3			TCGA-CV-6441-01A-11D-1683-08	TCGA-CV-6441-11A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	22b32736-3b91-4542-affa-46fa90819e69	2b352deb-ee25-4b74-bcb0-be4e445970d2	g.chrY:15816245C>G	uc004ftb.2	+	1	799	c.30C>G	c.(28-30)ATC>ATG	p.I10M		NM_004202	NP_004193	O14604	TYB4Y_HUMAN	thymosin, beta 4, Y chromosome	10					actin cytoskeleton organization|sequestering of actin monomers	cytoplasm|cytoskeleton	actin binding				0						TGGCTGAGATCGAGAAATTCG	0.483													4	5					0	0	0	0	G	15816245	G	G	15816245	3	3	191	1	0	0	0	0	1	0	0	0	16324	874	31	3	32	3	TMSB4Y	24	15816245	Missense_Mutation	SNP	C	TCGA-CV-6441-01A-11D-1683-08	9700623	15816245	43557321	260	35251											
MTOR	2475	broad.mit.edu	37	chr1	11298657	11298657	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atccgcacagtggcgaacaaAttgggtcagagagtggcctg	11	7	14	9	2	1	1	1	0	0	1	2	3	2	1	2	3	1	1	2	3	2	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:11298657A>G	uc001asd.2	-	12	1925	c.1804T>C	c.(1804-1806)TTT>CTT	p.F602L		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	602					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TGGCGAACAAATTGGGTCAGA	0.532													8	5					0	0	0	0	G	11298657	G	G	11298657	3	3	192	1	0	0	0	0	1	0	0	0	10007	101	4	5	6033	5	MTOR	1	11298657	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08		11298657	237951964	1	35252											
SYTL1	84958	broad.mit.edu	37	chr1	27677312	27677312	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcccgcaggccgagcttcagGgccgcgtgctgagcctgtct	4	8	14	15	4	2	1	1	1	1	0	3	2	3	1	4	2	3	3	4	2	0	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:27677312G>T	uc001bnw.1	+	11	1200	c.1033G>T	c.(1033-1035)GGC>TGC	p.G345C	SYTL1_uc001bnv.1_Missense_Mutation_p.G333C|SYTL1_uc009vsu.1_Intron|SYTL1_uc001bnx.2_3'UTR|SYTL1_uc009vsv.1_Missense_Mutation_p.G345C	NM_032872	NP_116261	Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	345	C2 1.				exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			ovary(1)	1		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGAGCTTCAGGGCCGCGTGCT	0.642													20	24					2.70639e-06	1.48852e-05	1	0	T	27677312	T	T	27677312	3	4	192	1	0	0	0	0	1	0	0	0	15548	1232	43	4	1035	4	SYTL1	1	27677312	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	16378655	27677312	221573309	2	35253											
BEND5	79656	broad.mit.edu	37	chr1	49202034	49202034	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgttccccaaatcataactgCcaagttcttcgtgtacttgg	9	14	7	11	1	2	0	1	0	1	0	4	0	3	0	3	1	3	3	3	1	4	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:49202034C>T	uc001crx.3	-	5	1029	c.985G>A	c.(985-987)GCA>ACA	p.A329T	AGBL4_uc001cru.2_Intron|AGBL4_uc010omw.1_Intron|AGBL4_uc010omx.1_Intron|AGBL4_uc001crv.1_Intron|AGBL4_uc010omy.1_Intron|BEND5_uc001crw.3_Missense_Mutation_p.A160T	NM_024603	NP_078879	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	329	BEN.									skin(1)	1						ATCATAACTGCCAAGTTCTTC	0.483													30	144					0	0	0	0	T	49202034	T	T	49202034	3	4	192	1	0	0	0	0	1	0	0	0	1403	739	26	4	288	4	BEND5	1	49202034	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	21524722	49202034	200048587	3	35254											
MYSM1	114803	broad.mit.edu	37	chr1	59131251	59131251	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtaagggattatttcgattaTagggactaacaatcatccca	14	12	8	7	1	1	0	1	0	0	0	3	3	2	2	1	2	1	1	1	2	6	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:59131251T>C	uc009wab.1	-	17	2107	c.2084A>G	c.(2083-2085)TAT>TGT	p.Y695C	MYSM1_uc009waa.1_Missense_Mutation_p.Y101C|MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	695					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					ATTTCGATTATAGGGACTAAC	0.333													9	67					0	0	0	0	C	59131251	C	C	59131251	3	2	192	1	0	0	0	0	1	0	0	0	10154	1406	49	5	418	5	MYSM1	1	59131251	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	9929217	59131251	190119370	4	35255											
GBP7	388646	broad.mit.edu	37	chr1	89616146	89616146	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtacttcttcaacatggagTaagagttttttgtcatttat	10	18	7	6	1	3	1	2	0	1	1	3	2	3	2	0	1	2	3	0	1	4	9			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:89616146T>A	uc001dna.2	-	6	877	c.738A>T	c.(736-738)TTA>TTT	p.L246F	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	246						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		CAACATGGAGTAAGAGTTTTT	0.383													22	49					0	0	0	0	A	89616146	A	A	89616146	3	1	192	1	0	0	0	0	1	0	0	0	6314	1635	57	5	1202	5	GBP7	1	89616146	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	30484895	89616146	159634475	5	35256											
LPPR4	9890	broad.mit.edu	37	chr1	99772515	99772515	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcaacagccccgaaaacacTagaaatatcttctacaaagg	18	6	6	11	1	2	1	0	0	2	1	2	2	2	1	2	1	5	1	2	1	8	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:99772515T>C	uc001dse.2	+	7	2347	c.2241T>C	c.(2239-2241)ACT>ACC	p.T747T	LPPR4_uc010oue.1_Silent_p.T689T	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	747							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CCGAAAACACTAGAAATATCT	0.473													23	55					0	0	0	0	C	99772515	C	C	99772515	2	2	192	1	0	0	0	0	0	0	0	1	8977	1509	53	5		5	LPPR4	1	99772515	Silent	SNP	T	TCGA-CV-6933-01A-11D-1912-08	10156369	99772515	149478106	6	35257											
SETDB1	9869	broad.mit.edu	37	chr1	150934615	150934615	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcttttccaggacactgacGaccgaaacaagatgtcagtg	12	10	9	10	2	2	2	1	1	1	1	3	5	3	3	2	1	1	0	2	1	2	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:150934615G>A	uc001evu.2	+	17	3329	c.3139G>A	c.(3139-3141)GAC>AAC	p.D1047N	SETDB1_uc001evv.2_Missense_Mutation_p.D1047N|SETDB1_uc009wmg.1_Missense_Mutation_p.D1047N	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	1047	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGACACTGACGACCGAAACAA	0.279													73	177					0	0	0	0	A	150934615	A	A	150934615	3	1	192	1	0	0	0	0	1	0	0	0	14203	1058	37	1	3201	1	SETDB1	1	150934615	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	51162100	150934615	98316006	7	35258											
HRNR	388697	broad.mit.edu	37	chr1	152187879	152187879	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccatagctgggagactgccTtgacccagacccacgctggc	8	6	12	15	1	0	3	0	1	0	2	0	4	0	3	4	2	2	2	4	2	1	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:152187879T>C	uc001ezt.1	-	3	6302	c.6226A>G	c.(6226-6228)AGG>GGG	p.R2076G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2076	23.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGACTGCCTTGACCCAGAC	0.627													4	274					0	0	0	0	C	152187879	C	C	152187879	3	2	192	1	0	0	0	0	1	0	0	0	7398	1608	56	5	2330	5	HRNR	1	152187879	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	1253264	152187879	97062742	8	35259											
FLG	2312	broad.mit.edu	37	chr1	152286148	152286148	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatcgctgactgcagatgaaGcttgcccgcgcccagtggct	7	8	13	13	3	0	3	0	2	0	1	1	4	0	3	2	1	3	4	2	1	1	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:152286148G>C	uc001ezu.1	-	3	1250	c.1214C>G	c.(1213-1215)GCT>GGT	p.A405G	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	405	Ser-rich.|Filaggrin 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCAGATGAAGCTTGCCCGCG	0.562									Ichthyosis				140	335					0	0	0	0	C	152286148	C	C	152286148	3	2	192	1	0	0	0	0	1	0	0	0	5954	971	34	4	10975	4	FLG	1	152286148	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	98269	152286148	96964473	9	35260											
DENND1B	163486	broad.mit.edu	37	chr1	197480968	197480968	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgtatcaagaatctctcCtagtaagtccatttcacctg	12	13	5	11	0	3	1	2	0	1	1	6	1	5	1	3	0	0	2	3	0	6	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:197480968C>T	uc010ppe.1	-	21	1983	c.1645G>A	c.(1645-1647)GGA>AGA	p.G549R	DENND1B_uc010ppf.1_RNA	NM_001142795	NP_001136267	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 1	Error:Variant_position_missing_in_Q6P3S1_after_alignment						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						AGAATCTCTCCTAGTAAGTCC	0.418													5	105					0	0	0	0	T	197480968	T	T	197480968	3	4	192	1	0	0	0	0	1	0	0	0	4449	690	24	4	630	4	DENND1B	1	197480968	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	45194820	197480968	51769653	10	35261											
PFKFB2	5208	broad.mit.edu	37	chr1	207236550	207236550	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cactgaggagaatggtcagaTtgcggtaagctttatctgct	10	12	12	7	1	2	3	1	1	1	2	2	4	2	3	0	3	3	3	0	3	3	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:207236550T>C	uc001hfg.2	+	5	480	c.371T>C	c.(370-372)ATT>ACT	p.I124T	PFKFB2_uc010psc.1_Missense_Mutation_p.I26T|PFKFB2_uc001hfh.2_Missense_Mutation_p.I124T|PFKFB2_uc009xcc.2_Missense_Mutation_p.I82T|PFKFB2_uc010psd.1_5'Flank	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	124	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					AATGGTCAGATTGCGGTAAGC	0.532													9	98					0	0	0	0	C	207236550	C	C	207236550	3	2	192	1	0	0	0	0	1	0	0	0	11816	1493	52	5	385	5	PFKFB2	1	207236550	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	9755582	207236550	42014071	11	35262											
PPP2R5A	5525	broad.mit.edu	37	chr1	212521732	212521732	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcctttttttccctccagtAttatcaatggctttgcattg	6	19	6	10	0	1	0	1	0	0	0	3	0	3	0	3	1	2	3	3	1	3	7			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:212521732A>T	uc001hjb.2	+	7	1340	c.766A>T	c.(766-768)ATT>TTT	p.I256F	PPP2R5A_uc010ptd.1_Missense_Mutation_p.I197F	NM_006243	NP_006234	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B	256					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)		TCCCTCCAGTATTATCAATGG	0.368													28	67					0	0	0	0	T	212521732	T	T	212521732	3	4	192	1	0	0	0	0	1	0	0	0	12452	463	16	5	792	5	PPP2R5A	1	212521732	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	5285182	212521732	36728889	12	35263											
BPNT1	10380	broad.mit.edu	37	chr1	220253139	220253139	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcctgccttttgagcaataGaatatgcggaggctaccaac	11	11	9	10	1	0	2	0	1	0	1	1	3	1	3	3	2	5	2	3	2	6	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:220253139G>C	uc001hma.2	-	2	222	c.50C>G	c.(49-51)TCT>TGT	p.S17C	BPNT1_uc010pug.1_Intron|BPNT1_uc010puh.1_Missense_Mutation_p.S17C|BPNT1_uc001hmb.3_Missense_Mutation_p.S17C	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	17					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)		TTGAGCAATAGAATATGCGGA	0.413													8	56					0	0	0	0	C	220253139	C	C	220253139	3	2	192	1	0	0	0	0	1	0	0	0	1499	942	33	2	908	2	BPNT1	1	220253139	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	7731407	220253139	28997482	13	35264											
WDR64	128025	broad.mit.edu	37	chr1	241958516	241958516	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttgttttgcagattcgaaGatatcccttggaaggtttcg	8	16	10	7	2	0	2	0	0	0	2	3	4	1	3	1	2	1	3	1	2	3	7			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:241958516G>C	uc001hzf.1	+	15	1787	c.1634G>C	c.(1633-1635)AGA>ACA	p.R545T	WDR64_uc001hzg.1_Missense_Mutation_p.R458T	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	992										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CAGATTCGAAGATATCCCTTG	0.338													28	117					0	0	0	0	C	241958516	C	C	241958516	3	2	192	1	0	0	0	0	1	0	0	0	17383	942	33	2	3073	2	WDR64	1	241958516	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	21705377	241958516	7292105	14	35265											
OR2T12	127064	broad.mit.edu	37	chr1	248458107	248458107	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacctgtgggatttgggtctCatataggtaaaaatgccagc	11	11	12	7	0	1	0	1	0	1	0	2	2	1	1	2	3	2	1	2	3	5	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:248458107C>T	uc010pzj.1	-	1	774	c.774G>A	c.(772-774)ATG>ATA	p.M258I		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATTTGGGTCTCATATAGGTAA	0.483													50	98					0	0	0	0	T	248458107	T	T	248458107	3	4	192	1	0	0	0	0	1	0	0	0	11073	826	29	2	191	2	OR2T12	1	248458107	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	6499591	248458107	792514	15	35266											
OR2T6	254879	broad.mit.edu	37	chr1	248551197	248551197	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaccatctctttcatcgcCtgcactgctcagtgctttct	5	14	8	14	1	4	0	2	0	2	0	6	1	4	1	2	1	3	3	2	1	0	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr1:248551197C>A	uc001iei.1	+	1	288	c.288C>A	c.(286-288)GCC>GCA	p.A96A		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTTTCATCGCCTGCACTGCTC	0.532													30	75					3.65163e-15	2.10275e-14	1	0	A	248551197	A	A	248551197	2	1	192	1	0	0	0	0	0	0	0	1	11083	668	24	4		4	OR2T6	1	248551197	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08	93090	248551197	699424	16	35267											
NBAS	51594	broad.mit.edu	37	chr2	15415923	15415923	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggactcatgttttcatctgtCagctttttgtaattaagacc	9	17	7	8	0	4	1	3	0	1	1	4	2	4	2	1	1	1	3	1	1	2	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:15415923C>T	uc002rcc.1	-	44	5435	c.5409G>A	c.(5407-5409)CTG>CTA	p.L1803L	NBAS_uc010exl.1_Silent_p.L875L|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1803										ovary(2)|liver(1)|skin(1)	4						TTTCATCTGTCAGCTTTTTGT	0.363													6	93					0	0	0	0	T	15415923	T	T	15415923	2	4	192	1	0	0	0	0	0	0	0	1	10239	813	29	2		2	NBAS	2	15415923	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08		15415923	227783450	17	35268											
AGBL5	60509	broad.mit.edu	37	chr2	27278036	27278036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcatcctccgacctgatgatCcccgggcccaaaccctccgt	7	8	7	19	3	1	2	1	2	0	0	5	3	5	2	8	1	1	0	8	1	1	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:27278036C>T	uc002rie.2	+	6	1040	c.823C>T	c.(823-825)CCC>TCC	p.P275S	AGBL5_uc002ric.2_Missense_Mutation_p.P275S|AGBL5_uc002rid.2_Missense_Mutation_p.P275S|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	275					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCTGATGATCCCCGGGCCCA	0.537													29	189					0	0	0	0	T	27278036	T	T	27278036	3	4	192	1	0	0	0	0	1	0	0	0	378	855	30	2	841	2	AGBL5	2	27278036	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	11862113	27278036	215921337	18	35269											
HEATR5B	54497	broad.mit.edu	37	chr2	37234297	37234298	+	In_Frame_Ins	INS	-	AACCAG	AACCAG																															agatgtagaacgtttttgtaINSaaccagatattgctgctgct																										TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:37234297_37234298insAACCAG	uc002rpp.1	-	29	4768_4769	c.4672_4673insCTGGTT	c.(4672-4674)TTA>TCTGGTTTA	p.1557_1558insSG	HEATR5B_uc010ezy.1_In_Frame_Ins_p.141_142insSG	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1557_1558							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				ACGTTTTTGTAAACCAGATATT	0.431													---	---	---								AACCAG	37234298	AACCAG	AACCAG	37234297	7	5	192	1	0	1	1	0	0	0	0	0	7071	372	13	0	1574	0	HEATR5B	2	37234297	In_Frame_Ins	INS	-	TCGA-CV-6933-01A-11D-1912-08	9956261	37234297	205965076	19	35270											
DPP10	57628	broad.mit.edu	37	chr2	116510763	116510763	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactagagaatactatatcActatggttaaatgggtaagc	17	11	8	5	0	1	1	1	0	0	1	1	2	1	1	0	2	3	2	0	2	10	7			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:116510763A>C	uc002tla.1	+	11	1421	c.964A>C	c.(964-966)ACT>CCT	p.T322P	DPP10_uc002tlb.1_Missense_Mutation_p.T272P|DPP10_uc002tlc.1_Missense_Mutation_p.T318P|DPP10_uc002tle.2_Missense_Mutation_p.T326P|DPP10_uc002tlf.1_Missense_Mutation_p.T315P	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	322	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ATACTATATCACTATGGTTAA	0.358													5	34					0	0	0	0	C	116510763	C	C	116510763	3	2	192	1	0	0	0	0	1	0	0	0	4749	159	6	5	1177	5	DPP10	2	116510763	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	79276466	116510763	126688610	20	35271											
ZRANB3	84083	broad.mit.edu	37	chr2	136111147	136111147	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattaacagaggccattcctCtttatagaagtaagtaattc	14	14	6	7	0	1	2	0	0	1	2	3	2	2	2	2	1	1	2	2	1	7	9			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:136111147C>G	uc002tum.2	-	4	349	c.232G>C	c.(232-234)GAG>CAG	p.E78Q	ZRANB3_uc002tuk.2_5'UTR|ZRANB3_uc002tul.2_Missense_Mutation_p.E78Q|ZRANB3_uc002tun.1_Missense_Mutation_p.E18Q	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	78	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		GGCCATTCCTCTTTATAGAAG	0.318													3	44					0	0	0	0	G	136111147	G	G	136111147	3	3	192	1	0	0	0	0	1	0	0	0	18291	922	32	2	3079	2	ZRANB3	2	136111147	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	19600384	136111147	107088226	21	35272											
LRP1B	53353	broad.mit.edu	37	chr2	141299370	141299370	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctattggtgtcattggcaacAgctatgattcccattggctg	8	14	10	9	0	1	1	1	1	0	0	2	1	2	1	1	3	2	3	1	3	3	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:141299370A>T	uc002tvj.1	-	44	8337	c.7365T>A	c.(7363-7365)GCT>GCA	p.A2455A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2455	Extracellular (Potential).|LDL-receptor class B 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATTGGCAACAGCTATGATTC	0.363										TSP Lung(27;0.18)			9	137					0	0	0	0	T	141299370	T	T	141299370	2	4	192	1	0	0	0	0	0	0	0	1	9005	175	7	5		5	LRP1B	2	141299370	Silent	SNP	A	TCGA-CV-6933-01A-11D-1912-08	5188223	141299370	101900003	22	35273											
KCNH7	90134	broad.mit.edu	37	chr2	163228467	163228467	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttttctttgccgcaggtGaagctctaaagagagatcac	11	12	10	8	1	3	3	1	1	2	2	3	4	3	3	1	1	2	3	1	1	3	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:163228467G>T	uc002uch.1	-	16	3675	c.3463C>A	c.(3463-3465)CAC>AAC	p.H1155N		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	1155	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TGCCGCAGGTGAAGCTCTAAA	0.428													8	47					1.12685e-05	6.04274e-05	1	0	T	163228467	T	T	163228467	3	4	192	1	0	0	0	0	1	0	0	0	8076	1290	45	2	131	2	KCNH7	2	163228467	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	21929097	163228467	79970906	23	35274											
SCN1A	6323	broad.mit.edu	37	chr2	166901572	166901572	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggtgtggggaggagtacCtcttttcatatgtcaatcgg	7	13	13	8	1	3	0	2	0	1	0	4	2	3	2	2	5	1	1	2	5	3	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr2:166901572C>G	uc010zcz.1	-	10	1661	c.1643G>C	c.(1642-1644)AGG>ACG	p.R548T	SCN1A_uc002udo.3_Missense_Mutation_p.R417T|SCN1A_uc010fpk.2_Missense_Mutation_p.R417T	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	548						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGAGGAGTACCTCTTTTCATA	0.433													44	82					0	0	0	0	G	166901572	G	G	166901572	3	3	192	1	0	0	0	0	1	0	0	0	13979	681	24	4	4454	4	SCN1A	2	166901572	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	3673105	166901572	76297801	24	35275											
PDCD6IP	10015	broad.mit.edu	37	chr3	33885692	33885692	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaggacaccatccaatgAactgtataagcctttaagag	16	8	8	9	0	0	2	0	1	0	1	1	3	1	3	3	1	2	2	3	1	6	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr3:33885692A>C	uc003cfx.2	+	11	1603	c.1448A>C	c.(1447-1449)GAA>GCA	p.E483A	PDCD6IP_uc003cfy.2_Missense_Mutation_p.E488A|PDCD6IP_uc011axw.1_Missense_Mutation_p.E264A	NM_013374	NP_037506	Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	483	Interaction with EIAV p9.|Interaction with CHMP4A, CHMP4B and CHMP4C.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2						CCATCCAATGAACTGTATAAG	0.343													4	63					0	0	0	0	C	33885692	C	C	33885692	3	2	192	1	0	0	0	0	1	0	0	0	11678	246	9	5	1505	5	PDCD6IP	3	33885692	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08		33885692	164136738	25	35276											
WDR53	348793	broad.mit.edu	37	chr3	196281606	196281606	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggtgactgtgggccttccaTttcttctgtttcatcctcct	4	17	8	12	0	3	1	1	1	2	0	6	1	6	1	4	2	0	1	4	2	0	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr3:196281606T>C	uc003fwt.2	-	4	1024	c.553A>G	c.(553-555)ATG>GTG	p.M185V		NM_182627	NP_872433	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	185										breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		GGGCCTTCCATTTCTTCTGTT	0.438													80	288					0	0	0	0	C	196281606	C	C	196281606	3	2	192	1	0	0	0	0	1	0	0	0	17373	1493	52	5	527	5	WDR53	3	196281606	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	162395914	196281606	1740824	26	35277											
CNGA1	1259	broad.mit.edu	37	chr4	47939078	47939078	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttcacaatcagcaaaaatgCgtaccttttttaatgtgtct	12	15	5	9	1	3	0	2	0	1	0	3	0	3	0	1	0	3	2	1	0	5	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr4:47939078C>T	uc003gxt.3	-	11	1699	c.1433G>A	c.(1432-1434)CGC>CAC	p.R478H	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Missense_Mutation_p.R547H	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	478	Extracellular (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						AGCAAAAATGCGTACCTTTTT	0.378													22	92					0	0	0	0	T	47939078	T	T	47939078	3	4	192	1	0	0	0	0	1	0	0	0	3611	768	27	1	643	1	CNGA1	4	47939078	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08		47939078	143215198	27	35278											
ANKRD17	26057	broad.mit.edu	37	chr4	73956863	73956863	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggcatcccattggtgtcTgaggcatagggtaagtcact	8	10	15	8	0	2	1	1	1	1	0	3	1	3	1	1	5	0	3	1	5	2	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr4:73956863T>A	uc003hgp.2	-	29	6599	c.6482A>T	c.(6481-6483)CAG>CTG	p.Q2161L	ANKRD17_uc003hgo.2_Missense_Mutation_p.Q2048L|ANKRD17_uc003hgq.2_Missense_Mutation_p.Q1910L|ANKRD17_uc003hgr.2_Missense_Mutation_p.Q2160L	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2161					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CATTGGTGTCTGAGGCATAGG	0.532													39	170					0	0	0	0	A	73956863	A	A	73956863	3	1	192	1	0	0	0	0	1	0	0	0	646	1580	55	5	1353	5	ANKRD17	4	73956863	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	26017785	73956863	117197413	28	35279											
DMP1	1758	broad.mit.edu	37	chr4	88584472	88584472	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gactgccaagacggctattaGcatcagctgtcctaagaagc	12	8	10	11	1	1	2	1	0	0	2	2	3	2	2	2	1	4	3	2	1	5	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr4:88584472G>C	uc003hqv.2	+	6	1646	c.1542G>C	c.(1540-1542)TAG>TAC	p.*514Y	DMP1_uc003hqw.2_Nonstop_Mutation_p.*498Y	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	514					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		ACGGCTATTAGCATCAGCTGT	0.373													32	134					0	0	0	0	C	88584472	C	C	88584472	4	2	192	1	0	0	0	0	0	0	0	0	4605	966	34	4	1560	4	DMP1	4	88584472	Nonstop_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	14627609	88584472	102569804	29	35280											
PDHA2	5161	broad.mit.edu	37	chr4	96761919	96761919	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcagatagccgaagctttCaatatggcagctttatggaa	12	10	12	7	1	1	1	1	0	0	1	1	3	1	2	1	3	3	4	1	3	6	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr4:96761919C>T	uc003htr.3	+	1	681	c.618C>T	c.(616-618)TTC>TTT	p.F206F		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	206					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CCGAAGCTTTCAATATGGCAG	0.443													14	49					0	0	0	0	T	96761919	T	T	96761919	2	4	192	1	0	0	0	0	0	0	0	1	11719	825	29	2		2	PDHA2	4	96761919	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08	8177447	96761919	94392357	30	35281											
C4orf31	79625	broad.mit.edu	37	chr4	121958183	121958183	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctgttgatgttgaccacaaAtacatcaaagtagtactgcg	13	11	9	8	1	1	2	1	2	0	0	1	2	1	2	1	0	3	5	1	0	5	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr4:121958183A>T	uc003idq.1	-	4	1470	c.943T>A	c.(943-945)TTT>ATT	p.F315I		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	315	Fibronectin type-III 1.										0						TTGACCACAAATACATCAAAG	0.453													15	71					0	0	0	0	T	121958183	T	T	121958183	3	4	192	1	0	0	0	0	1	0	0	0	2271	101	4	5	767	5	C4orf31	4	121958183	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	25196264	121958183	69196093	31	35282											
CMYA5	202333	broad.mit.edu	37	chr5	79027402	79027402	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaatttatcagaagaagaTcaagaagacattggaccttt	17	11	8	5	0	2	6	2	1	0	5	2	7	2	7	1	1	0	0	1	1	6	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr5:79027402T>C	uc003kgc.2	+	2	2886	c.2814T>C	c.(2812-2814)GAT>GAC	p.D938D		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	938						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CAGAAGAAGATCAAGAAGACA	0.413													48	39					0	0	0	0	C	79027402	C	C	79027402	2	2	192	1	0	0	0	0	0	0	0	1	3605	1432	50	5		5	CMYA5	5	79027402	Silent	SNP	T	TCGA-CV-6933-01A-11D-1912-08		79027402	101887858	32	35283											
GPR98	84059	broad.mit.edu	37	chr5	90041015	90041015	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caagcaagaatttaatagctCtagtgggagctcattcacat	14	11	8	8	0	3	1	2	0	1	1	3	2	3	2	0	1	3	3	0	1	6	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr5:90041015C>G	uc003kju.2	+	51	10798	c.10702C>G	c.(10702-10704)CTA>GTA	p.L3568V	GPR98_uc003kjt.2_Missense_Mutation_p.L1274V|GPR98_uc003kjv.2_Missense_Mutation_p.L1168V	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3568	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTAATAGCTCTAGTGGGAGC	0.368													40	134					0	0	0	0	G	90041015	G	G	90041015	3	3	192	1	0	0	0	0	1	0	0	0	6760	912	32	2	10904	2	GPR98	5	90041015	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	11013613	90041015	90874245	33	35284											
CYFIP2	26999	broad.mit.edu	37	chr5	156741393	156741393	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacagccagaagtcagacgaGgagtatcgcgagctcttcga	12	6	13	10	4	2	2	1	0	1	2	4	7	2	3	1	1	2	2	1	1	2	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr5:156741393G>A	uc003lwq.2	+	14	1290	c.1152G>A	c.(1150-1152)GAG>GAA	p.E384E	CYFIP2_uc011ddn.1_Silent_p.E358E|CYFIP2_uc011ddo.1_Silent_p.E188E|CYFIP2_uc003lwr.2_Silent_p.E384E|CYFIP2_uc003lws.2_Silent_p.E384E|CYFIP2_uc003lwt.2_Silent_p.E262E|CYFIP2_uc011ddp.1_Silent_p.E118E	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	384					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTCAGACGAGGAGTATCGCG	0.517													22	35					0	0	0	0	A	156741393	A	A	156741393	2	1	192	1	0	0	0	0	0	0	0	1	4155	991	35	4		4	CYFIP2	5	156741393	Silent	SNP	G	TCGA-CV-6933-01A-11D-1912-08	66700378	156741393	24173867	34	35285											
FGFR4	2264	broad.mit.edu	37	chr5	176519733	176519733	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgagtacacctgcctcgcAggcaattccatcggcctctc	7	8	10	16	3	1	0	0	0	1	0	5	1	2	0	4	3	2	3	4	3	2	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr5:176519733A>G	uc003mfl.2	+	8	1172	c.1005A>G	c.(1003-1005)GCA>GCG	p.A335A	FGFR4_uc003mfm.2_Silent_p.A335A|FGFR4_uc011dfu.1_Silent_p.A335A|FGFR4_uc011dfw.1_Silent_p.A335A|FGFR4_uc003mfo.2_Silent_p.A335A	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	335	Extracellular (Potential).|Ig-like C2-type 3.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CCTGCCTCGCAGGCAATTCCA	0.637										TSP Lung(9;0.080)			23	31					0	0	0	0	G	176519733	G	G	176519733	2	3	192	1	0	0	0	0	0	0	0	1	5900	175	7	5		5	FGFR4	5	176519733	Silent	SNP	A	TCGA-CV-6933-01A-11D-1912-08	19778340	176519733	4395527	35	35286											
PRPF4B	8899	broad.mit.edu	37	chr6	4037761	4037761	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctcgttccccactcagaCgtagcaggtctccaagaaga	10	8	10	13	2	3	3	1	0	2	3	6	3	4	3	3	2	1	3	3	2	3	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:4037761C>T	uc003mvv.2	+	3	1460	c.1369C>T	c.(1369-1371)CGT>TGT	p.R457C	PRPF4B_uc003mvw.2_RNA|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	457	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CCCACTCAGACGTAGCAGGTC	0.448													20	41					0	0	0	0	T	4037761	T	T	4037761	3	4	192	1	0	0	0	0	1	0	0	0	12635	536	19	1	1379	1	PRPF4B	6	4037761	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08		4037761	167077306	36	35287											
HIST1H4E	8367	broad.mit.edu	37	chr6	26205025	26205025	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcgcatttctggtctcatCtacgaggagactcgcggggt	8	10	13	10	4	3	1	1	0	3	1	5	3	3	1	0	4	2	1	0	4	2	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:26205025C>A	uc003ngy.2	+	1	153	c.153C>A	c.(151-153)ATC>ATA	p.I51I		NM_003545	NP_003536	P62805	H4_HUMAN	histone cluster 1, H4e	51					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				CTGGTCTCATCTACGAGGAGA	0.562													38	68					6.99958e-10	3.92525e-09	1	0	A	26205025	A	A	26205025	2	1	192	1	0	0	0	0	0	0	0	1	7208	903	32	2		2	HIST1H4E	6	26205025	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08	22167264	26205025	144910042	37	35288											
HIST1H1B	3009	broad.mit.edu	37	chr6	27834842	27834842	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gggcttcttcgccttcttcgGagtcttcttcactgcctttt	2	18	8	13	2	5	0	1	0	4	0	7	1	5	1	2	2	1	1	2	2	0	8			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:27834842G>C	uc003njx.2	-	1	518	c.466C>G	c.(466-468)CCG>GCG	p.P156A		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	156					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						GCCTTCTTCGGAGTCTTCTTC	0.602													5	231					0	0	0	0	C	27834842	C	C	27834842	3	2	192	1	0	0	0	0	1	0	0	0	7162	1174	41	2	218	2	HIST1H1B	6	27834842	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	1629817	27834842	143280225	38	35289											
ZBTB22	9278	broad.mit.edu	37	chr6	33283873	33283873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccagccccaggaaccactGcccccctcccatccccacca	8	3	5	25	0	0	0	0	0	0	0	2	1	2	1	11	1	3	0	11	1	1	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:33283873G>A	uc003oeb.2	-	2	973	c.821C>T	c.(820-822)GCA>GTA	p.A274V	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.A274V	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGGAACCACTGCCCCCCTCCC	0.607													12	45					0	0	0	0	A	33283873	A	A	33283873	3	1	192	1	0	0	0	0	1	0	0	0	17597	1319	46	4	1087	4	ZBTB22	6	33283873	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	5449031	33283873	137831194	39	35290											
BYSL	705	broad.mit.edu	37	chr6	41889501	41889501	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagcacggcagcaacaggaGgaactcgaggccgagcatgg	13	2	15	11	3	0	0	0	0	0	0	1	4	0	2	1	5	5	4	1	5	3	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:41889501G>C	uc003orl.2	+	1	537	c.201G>C	c.(199-201)GAG>GAC	p.E67D	MED20_uc003orj.2_5'Flank|MED20_uc003ork.2_5'Flank|MED20_uc011duh.1_5'Flank|MED20_uc011dui.1_5'Flank|MED20_uc011duj.1_5'Flank	NM_004053	NP_004044	Q13895	BYST_HUMAN	bystin	67					cell adhesion|female pregnancy|ribosome biogenesis	cytoplasm|nucleolus					0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000473)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGCAACAGGAGGAACTCGAGG	0.677											OREG0017436	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	26					0	0	0	0	C	41889501	C	C	41889501	3	2	192	1	0	0	0	0	1	0	0	0	1581	991	35	4	203	4	BYSL	6	41889501	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	8605628	41889501	129225566	40	35291											
PRIM2	5558	broad.mit.edu	37	chr6	57512691	57512691	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactagaggattactttagtGaagattcttaggcagttttg	11	15	11	4	0	1	3	0	1	1	2	1	5	1	4	0	2	1	2	0	2	5	8			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:57512691G>A	uc003pdx.2	+	15	1606	c.1519G>A	c.(1519-1521)GAA>AAA	p.E507K		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	507					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TTACTTTAGTGAAGATTCTTA	0.333													16	473					0	0	0	0	A	57512691	A	A	57512691	3	1	192	1	0	0	0	0	1	0	0	0	12553	1291	45	2	1569	2	PRIM2	6	57512691	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	15623190	57512691	113602376	41	35292											
DOPEY1	23033	broad.mit.edu	37	chr6	83849755	83849755	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaattattccaccagatatGattcttactcttttggaagg	11	16	6	8	0	3	2	1	1	2	1	4	3	4	3	2	2	1	0	2	2	5	7			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:83849755G>A	uc003pjs.1	+	22	5417	c.5157G>A	c.(5155-5157)ATG>ATA	p.M1719I	DOPEY1_uc011dyy.1_Missense_Mutation_p.M1710I|DOPEY1_uc010kbl.1_Missense_Mutation_p.M1710I|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1719					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CACCAGATATGATTCTTACTC	0.338													9	41					0	0	0	0	A	83849755	A	A	83849755	3	1	192	1	0	0	0	0	1	0	0	0	4729	1290	45	2	5235	2	DOPEY1	6	83849755	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	26337064	83849755	87265312	42	35293											
PGM3	5238	broad.mit.edu	37	chr6	83896760	83896760	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctagaacagtcacaccatCtattacagattgtgaaagtt	14	12	6	9	0	2	3	1	1	1	2	3	3	3	3	2	0	2	1	2	0	5	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:83896760C>T	uc003pjv.2	-	4	464	c.424G>A	c.(424-426)GAT>AAT	p.D142N	PGM3_uc003pjw.2_Missense_Mutation_p.D61N|PGM3_uc011dyz.1_Missense_Mutation_p.D170N	NM_015599	NP_056414	O95394	AGM1_HUMAN	phosphoglucomutase 3	142					dolichol-linked oligosaccharide biosynthetic process|embryo development ending in birth or egg hatching|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity				0		all_cancers(76;0.000504)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.068)		BRCA - Breast invasive adenocarcinoma(397;0.0478)		GTCACACCATCTATTACAGAT	0.328													20	61					0	0	0	0	T	83896760	T	T	83896760	3	4	192	1	0	0	0	0	1	0	0	0	11855	913	32	2	1244	2	PGM3	6	83896760	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	47005	83896760	87218307	43	35294											
RRAGD	58528	broad.mit.edu	37	chr6	90097155	90097155	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgttggaaacatcttcccgGcatatcttattagtgctctc	8	15	7	11	1	3	0	0	0	3	0	5	1	4	1	1	2	2	3	1	2	4	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:90097155G>T	uc003pnd.3	-	2	586	c.303C>A	c.(301-303)TGC>TGA	p.C101*	RRAGD_uc010kcc.2_Intron	NM_021244	NP_067067	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	101					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			ovary(2)|central_nervous_system(1)	3		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		CATCTTCCCGGCATATCTTAT	0.428													98	190					5.01286e-43	2.98683e-42	1	0	T	90097155	T	T	90097155	4	4	192	1	0	0	0	0	0	1	0	0	13740	1195	42	4	923	4	RRAGD	6	90097155	Nonsense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	6200395	90097155	81017912	44	35295											
WASF1	8936	broad.mit.edu	37	chr6	110421867	110421867	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttcacgctgctcttctactTtgcgtagctgaatacctgat	7	15	8	11	2	3	2	1	2	2	0	3	2	3	2	1	0	5	5	1	0	4	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:110421867T>C	uc003ptv.1	-	11	2375	c.1538A>G	c.(1537-1539)AAA>AGA	p.K513R	WASF1_uc003ptw.1_Missense_Mutation_p.K513R|WASF1_uc003ptx.1_Missense_Mutation_p.K513R|WASF1_uc003pty.1_Missense_Mutation_p.K513R	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	513	WH2.				actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		CTCTTCTACTTTGCGTAGCTG	0.363													14	27					0	0	0	0	C	110421867	C	C	110421867	3	2	192	1	0	0	0	0	1	0	0	0	17320	1841	64	5	145	5	WASF1	6	110421867	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	20324712	110421867	60693200	45	35296											
ROS1	6098	broad.mit.edu	37	chr6	117724426	117724426	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggcttgaccacataggaCggtctggacacagtctagat	11	8	13	9	1	2	2	0	1	2	1	2	4	2	4	1	5	0	1	1	5	2	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:117724426C>T	uc003pxp.1	-	6	652	c.453G>A	c.(451-453)CCG>CCA	p.P151P	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	151	Fibronectin type-III 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CCACATAGGACGGTCTGGACA	0.473			T	GOPC|ROS1	glioblastoma|NSCLC								11	26					0	0	0	0	T	117724426	T	T	117724426	2	4	192	1	0	0	0	0	0	0	0	1	13596	523	19	1		1	ROS1	6	117724426	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08	7302559	117724426	53390641	46	35297											
PTPRK	5796	broad.mit.edu	37	chr6	128404886	128404886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttgagtgatgattccatttgGatccaaaggttctttccagt	9	16	9	7	0	1	3	0	3	1	0	4	4	4	4	3	2	0	1	3	2	1	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:128404886G>C	uc003qbk.2	-	9	1916	c.1549C>G	c.(1549-1551)CCA>GCA	p.P517A	PTPRK_uc003qbj.2_Missense_Mutation_p.P517A|PTPRK_uc010kfc.2_Missense_Mutation_p.P517A|PTPRK_uc011ebu.1_Missense_Mutation_p.P517A|PTPRK_uc003qbl.1_Missense_Mutation_p.P387A|PTPRK_uc011ebv.1_Missense_Mutation_p.P517A	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	517	Extracellular (Potential).|Fibronectin type-III 3.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ATTCCATTTGGATCCAAAGGT	0.368													23	99					0	0	0	0	C	128404886	C	C	128404886	3	2	192	1	0	0	0	0	1	0	0	0	12870	1174	41	2	2883	2	PTPRK	6	128404886	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	10680460	128404886	42710181	47	35298											
REPS1	85021	broad.mit.edu	37	chr6	139266690	139266690	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatcatggcttacggatcccTttttcacttgccccctgcca	6	14	6	15	1	2	0	2	0	0	0	3	1	3	1	4	2	3	1	4	2	2	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr6:139266690T>C	uc003qii.2	-	3	1001	c.422A>G	c.(421-423)AAG>AGG	p.K141R	REPS1_uc003qig.3_Missense_Mutation_p.K141R|REPS1_uc011edr.1_Missense_Mutation_p.K141R|REPS1_uc003qij.2_Missense_Mutation_p.K141R|REPS1_uc003qik.2_5'UTR	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	141						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TACGGATCCCTTTTTCACTTG	0.478													3	138					0	0	0	0	C	139266690	C	C	139266690	3	2	192	1	0	0	0	0	1	0	0	0	13293	1609	56	5	2040	5	REPS1	6	139266690	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	10861804	139266690	31848377	48	35299											
THSD7A	221981	broad.mit.edu	37	chr7	11675953	11675953	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctttattcttcccgcgtcTccttgcttgtcttacttgtc	2	21	5	13	2	4	0	0	0	4	0	7	0	5	0	2	0	2	1	2	0	2	9			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:11675953T>A	uc003ssf.3	-	2	1078	c.826A>T	c.(826-828)AGA>TGA	p.R276*		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	276	Extracellular (Potential).|Potential.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTCCCGCGTCTCCTTGCTTGT	0.537										HNSCC(18;0.044)			32	95					0	0	0	0	A	11675953	A	A	11675953	4	1	192	1	0	0	0	0	0	1	0	0	15945	1559	54	5	4251	5	THSD7A	7	11675953	Nonsense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08		11675953	147462710	49	35300											
STK31	56164	broad.mit.edu	37	chr7	23825129	23825129	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctccttacaatgagcttggaAcgagatcttcttgatgctga	10	13	9	9	1	2	4	0	3	2	1	3	6	3	5	1	1	4	2	1	1	3	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:23825129A>G	uc003sws.3	+	18	2248	c.2181A>G	c.(2179-2181)GAA>GAG	p.E727E	STK31_uc003swt.3_Silent_p.E704E|STK31_uc011jze.1_Silent_p.E727E|STK31_uc010kuq.2_Silent_p.E704E|STK31_uc003swv.1_5'Flank	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	727	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TGAGCTTGGAACGAGATCTTC	0.403													35	90					0	0	0	0	G	23825129	G	G	23825129	2	3	192	1	0	0	0	0	0	0	0	1	15362	40	2	5		5	STK31	7	23825129	Silent	SNP	A	TCGA-CV-6933-01A-11D-1912-08	12149176	23825129	135313534	50	35301											
NPC1L1	29881	broad.mit.edu	37	chr7	44556434	44556434	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgcaggtccaggcccagcagGaggcaggagacagcgaaggt	11	2	17	11	2	0	1	0	0	0	1	1	4	1	2	2	6	2	3	2	6	1	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:44556434G>A	uc003tlb.2	-	17	3524	c.3468C>T	c.(3466-3468)CTC>CTT	p.L1156L	NPC1L1_uc003tlc.2_Silent_p.L1129L|NPC1L1_uc011kbw.1_Silent_p.L1083L|NPC1L1_uc003tla.2_Intron	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1156	Helical; Name=10; (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GGCCCAGCAGGAGGCAGGAGA	0.592													14	42					0	0	0	0	A	44556434	A	A	44556434	2	1	192	1	0	0	0	0	0	0	0	1	10625	1161	41	2		2	NPC1L1	7	44556434	Silent	SNP	G	TCGA-CV-6933-01A-11D-1912-08	20731305	44556434	114582229	51	35302											
EGFR	1956	broad.mit.edu	37	chr7	55210124	55210124	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaattatgatctttccttCttaaaggttggtgactttga	10	17	9	5	0	2	3	0	3	2	0	3	4	3	4	1	3	0	1	1	3	4	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:55210124C>G	uc003tqk.2	+	2	480	c.234C>G	c.(232-234)TTC>TTG	p.F78L	EGFR_uc003tqh.2_Missense_Mutation_p.F78L|EGFR_uc003tqi.2_Missense_Mutation_p.F78L|EGFR_uc003tqj.2_Missense_Mutation_p.F78L|EGFR_uc010kzg.1_Missense_Mutation_p.F78L|EGFR_uc011kco.1_Missense_Mutation_p.F25L	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	78	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATCTTTCCTTCTTAAAGGTTG	0.378		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			8	869					0	0	0	0	G	55210124	G	G	55210124	3	3	192	1	0	0	0	0	1	0	0	0	4989	912	32	2	240	2	EGFR	7	55210124	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	10653690	55210124	103928539	52	35303											
ZNF479	90827	broad.mit.edu	37	chr7	57188238	57188238	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcttcacatttgtagggtCtctctccagtatgaattctc	8	17	6	10	0	5	1	1	1	4	0	8	1	5	1	1	1	0	2	1	1	3	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:57188238C>G	uc010kzo.2	-	5	1155	c.884G>C	c.(883-885)AGA>ACA	p.R295T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTTGTAGGGTCTCTCTCCAGT	0.473													6	70					0	0	0	0	G	57188238	G	G	57188238	3	3	192	1	0	0	0	0	1	0	0	0	18000	913	32	2	694	2	ZNF479	7	57188238	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	1978114	57188238	101950425	53	35304											
POM121	9883	broad.mit.edu	37	chr7	72413634	72413634	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctatctttggcggtgccacGcactcggcgtttgggttgaa	5	12	13	11	4	1	1	0	1	1	0	2	1	1	1	2	4	1	3	2	4	2	4	rs139238552	byFrequency	TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:72413634G>A	uc003twk.2	+	11	3102	c.3102G>A	c.(3100-3102)ACG>ACA	p.T1034T	POM121_uc003twj.2_Silent_p.T769T|POM121_uc010lam.1_Silent_p.T769T	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1034	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				GCGGTGCCACGCACTCGGCGT	0.652													18	154					0	0	0	0	A	72413634	A	A	72413634	2	1	192	1	0	0	0	0	0	0	0	1	12294	1074	38	1		1	POM121	7	72413634	Silent	SNP	G	TCGA-CV-6933-01A-11D-1912-08	15225396	72413634	86725029	54	35305											
STEAP4	79689	broad.mit.edu	37	chr7	87913172	87913172	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgactggagagcccaggctGagatggtgttaaatgctttt	9	12	13	7	0	0	3	0	2	0	2	0	5	0	3	1	3	2	3	1	3	2	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:87913172G>C	uc003ujs.2	-	2	518	c.413C>G	c.(412-414)TCA>TGA	p.S138*	STEAP4_uc010lek.2_Nonsense_Mutation_p.S138*|STEAP4_uc003ujt.2_Nonsense_Mutation_p.S138*	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	138					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					AGCCCAGGCTGAGATGGTGTT	0.418													404	101					0	0	0	0	C	87913172	C	C	87913172	4	2	192	1	0	0	0	0	0	1	0	0	15346	1294	45	2	982	2	STEAP4	7	87913172	Nonsense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	15499538	87913172	71225491	55	35306											
PIK3CG	5294	broad.mit.edu	37	chr7	106513012	106513012	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaccataccatgatagcGcccttgccagatttctgctg	9	12	8	12	1	1	3	0	2	1	1	1	3	1	3	4	0	5	1	4	0	3	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:106513012G>A	uc003vdv.3	+	3	2111	c.2026G>A	c.(2026-2028)GCC>ACC	p.A676T	PIK3CG_uc003vdu.2_Missense_Mutation_p.A676T|PIK3CG_uc003vdw.2_Missense_Mutation_p.A676T	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	676					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CCATGATAGCGCCCTTGCCAG	0.393													78	116					0	0	0	0	A	106513012	A	A	106513012	3	1	192	1	0	0	0	0	1	0	0	0	11971	1087	38	1	2032	1	PIK3CG	7	106513012	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	18599840	106513012	52625651	56	35307											
NRCAM	4897	broad.mit.edu	37	chr7	107820812	107820813	+	Frame_Shift_Ins	INS	-	T	T																															tgccttggaaggtgaggatcINStttttctcaatgtgacgtct																								rs139634064		TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr7:107820812_107820813insT	uc003vfb.2	-	25	3176_3177	c.2705_2706insA	c.(2704-2706)AAGfs	p.K902fs	NRCAM_uc003vfc.2_Frame_Shift_Ins_p.K886fs|NRCAM_uc011kmk.1_Frame_Shift_Ins_p.K897fs|NRCAM_uc003vfd.2_Frame_Shift_Ins_p.K878fs|NRCAM_uc003vfe.2_Frame_Shift_Ins_p.K878fs	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	902	Fibronectin type-III 3.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						AGGTGAGGATCTTTTTCTCAAT	0.47													---	---	---								T	107820813	T	T	107820812	7	5	192	1	0	1	1	0	0	0	0	0	10698	912	32	0	1274	0	NRCAM	7	107820812	Frame_Shift_Ins	INS	-	TCGA-CV-6933-01A-11D-1912-08	1307800	107820812	51317851	57	35308											
DOCK5	80005	broad.mit.edu	37	chr8	25154152	25154152	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaaaggattgaggaaaagatCcaagaagagaaggtacagtt	20	6	12	3	0	0	4	0	1	0	3	1	7	1	6	1	3	1	2	1	3	8	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:25154152C>T	uc003xeg.2	+	7	731	c.594C>T	c.(592-594)ATC>ATT	p.I198I	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_5'UTR|DOCK5_uc003xef.2_Silent_p.I198I	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	198						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		AGGAAAAGATCCAAGAAGAGA	0.448													8	14					0	0	0	0	T	25154152	T	T	25154152	2	4	192	1	0	0	0	0	0	0	0	1	4712	845	30	2		2	DOCK5	8	25154152	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08		25154152	121209870	58	35309											
CDCA2	157313	broad.mit.edu	37	chr8	25365207	25365207	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgggaagggagagagctctCtgactgccttggaaaggatt	11	9	15	6	0	1	2	0	1	1	1	2	7	1	6	1	4	2	1	1	4	2	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:25365207C>G	uc003xep.1	+	15	3504	c.3025C>G	c.(3025-3027)CTG>GTG	p.L1009V	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.L994V|CDCA2_uc003xer.1_Missense_Mutation_p.L672V	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	1009					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		AGAGAGCTCTCTGACTGCCTT	0.433													15	99					0	0	0	0	G	25365207	G	G	25365207	3	3	192	1	0	0	0	0	1	0	0	0	3101	912	32	2	3079	2	CDCA2	8	25365207	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	211055	25365207	120998815	59	35310											
KIAA0146	23514	broad.mit.edu	37	chr8	48614380	48614380	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgacgaagaccccatttataAgctttaccagcctccagtta	12	11	6	12	1	0	2	0	1	0	1	1	3	1	2	5	0	3	2	5	0	5	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:48614380A>G	uc003xqd.2	+	13	1880	c.1871A>G	c.(1870-1872)AAG>AGG	p.K624R	KIAA0146_uc011ldb.1_Missense_Mutation_p.K624R|KIAA0146_uc010lxs.2_Missense_Mutation_p.K99R|KIAA0146_uc011ldc.1_Missense_Mutation_p.K554R|KIAA0146_uc011ldd.1_Missense_Mutation_p.K564R|KIAA0146_uc003xqe.2_Missense_Mutation_p.K99R|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.K313R|KIAA0146_uc010lxt.2_Missense_Mutation_p.K313R|KIAA0146_uc011ldf.1_Missense_Mutation_p.K129R|KIAA0146_uc011ldg.1_Missense_Mutation_p.K114R|KIAA0146_uc010lxv.1_Missense_Mutation_p.K118R	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	624											0		Lung NSC(58;0.175)				CCCATTTATAAGCTTTACCAG	0.428													91	170					0	0	0	0	G	48614380	G	G	48614380	3	3	192	1	0	0	0	0	1	0	0	0	8196	72	3	5	1921	5	KIAA0146	8	48614380	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	23249173	48614380	97749642	60	35311											
TRPA1	8989	broad.mit.edu	37	chr8	72948640	72948640	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacaaaaatgatgcccgtcGtgtagataatccattcaaga	15	9	8	9	2	1	3	1	1	0	2	3	3	2	3	2	0	1	2	2	0	5	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:72948640G>A	uc003xza.2	-	21	2613	c.2438C>T	c.(2437-2439)ACG>ATG	p.T813M	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	813	Helical; Name=3; (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GATGCCCGTCGTGTAGATAAT	0.363													14	53					0	0	0	0	A	72948640	A	A	72948640	3	1	192	1	0	0	0	0	1	0	0	0	16644	1145	40	1	949	1	TRPA1	8	72948640	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	24334260	72948640	73415382	61	35312											
RIMS2	9699	broad.mit.edu	37	chr8	104987601	104987601	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcgacatgatggtcgagatCttcaaagctcaacattatca	14	11	7	9	2	4	2	3	1	1	1	6	4	4	2	0	1	2	1	0	1	3	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:104987601C>G	uc003yls.2	+	14	2369	c.2128C>G	c.(2128-2130)CTT>GTT	p.L710V	RIMS2_uc003ylp.2_Missense_Mutation_p.L932V|RIMS2_uc003ylw.2_Missense_Mutation_p.L724V|RIMS2_uc003ylq.2_Missense_Mutation_p.L724V|RIMS2_uc003ylr.2_Missense_Mutation_p.L771V|RIMS2_uc003ylt.2_Missense_Mutation_p.L317V	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	994					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGGTCGAGATCTTCAAAGCTC	0.358										HNSCC(12;0.0054)			8	29					0	0	0	0	G	104987601	G	G	104987601	3	3	192	1	0	0	0	0	1	0	0	0	13433	913	32	2	2982	2	RIMS2	8	104987601	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	32038961	104987601	41376421	62	35313											
TM7SF4	81501	broad.mit.edu	37	chr8	105361225	105361225	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaatatattgaggcaattCagtggatttatggccttgcc	13	13	9	6	0	1	1	1	1	0	0	1	2	1	2	2	3	1	1	2	3	6	7			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:105361225C>T	uc003ylx.1	+	2	494	c.445C>T	c.(445-447)CAG>TAG	p.Q149*		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	149					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGAGGCAATTCAGTGGATTTA	0.418													14	84					0	0	0	0	T	105361225	T	T	105361225	4	4	192	1	0	0	0	0	0	1	0	0	16042	827	29	2	447	2	TM7SF4	8	105361225	Nonsense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	373624	105361225	41002797	63	35314											
LRP12	29967	broad.mit.edu	37	chr8	105521276	105521276	+	Frame_Shift_Del	DEL	G	-	-																															gattatgccacttggtgctcGtatttgctctggagtctctc																										TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:105521276delG	uc003yma.2	-	3	258	c.163delC	c.(163-165)CGAfs	p.R55fs	LRP12_uc003ymb.2_Frame_Shift_Del_p.R36fs|LRP12_uc003ymc.3_Frame_Shift_Del_p.R36fs	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	55	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTGGTGCTCGTATTTGCTCT	0.408													---	---	---								-	105521276	-	-	105521276	7	5	192	1	0	1	0	1	0	0	0	0	9004	1153	40	0	2436	0	LRP12	8	105521276	Frame_Shift_Del	DEL	G	TCGA-CV-6933-01A-11D-1912-08	160051	105521276	40842746	64	35315											
CSMD3	114788	broad.mit.edu	37	chr8	113988168	113988168	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggatgaggagagagccCgtccttggacgtgttggggt	6	10	18	7	2	0	2	0	1	0	1	1	6	1	5	2	5	2	2	2	5	0	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:113988168C>A	uc003ynu.2	-	7	1399	c.1240G>T	c.(1240-1242)GGG>TGG	p.G414W	CSMD3_uc003ynt.2_Missense_Mutation_p.G374W|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	414	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGAGAGAGCCCGTCCTTGGAC	0.478										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	117					6.33239e-15	3.62213e-14	1	0	A	113988168	A	A	113988168	3	1	192	1	0	0	0	0	1	0	0	0	3963	652	23	3	10143	3	CSMD3	8	113988168	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	8466892	113988168	32375854	65	35316											
COL22A1	169044	broad.mit.edu	37	chr8	139601580	139601580	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacattggcctgggggaccGggaggtcctgggaggccagg	6	6	19	10	1	1	0	1	0	0	0	2	3	2	3	4	8	0	0	4	8	0	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:139601580G>A	uc003yvd.2	-	65	5244	c.4797C>T	c.(4795-4797)CCC>CCT	p.P1599P	COL22A1_uc011ljo.1_Silent_p.P879P	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1599	Pro-rich.|Gly-rich.|Collagen-like 16.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTGGGGGACCGGGAGGTCCTG	0.622										HNSCC(7;0.00092)			7	36					0	0	0	0	A	139601580	A	A	139601580	2	1	192	1	0	0	0	0	0	0	0	1	3696	1103	39	1		1	COL22A1	8	139601580	Silent	SNP	G	TCGA-CV-6933-01A-11D-1912-08	25613412	139601580	6762442	66	35317											
ZNF250	58500	broad.mit.edu	37	chr8	146107136	146107136	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgaaggctttgccacattCtgtgcactggaagggctttt	7	13	12	9	0	1	1	0	1	1	0	1	2	1	2	1	3	2	4	1	3	2	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:146107136C>G	uc003zeq.3	-	6	1564	c.1447G>C	c.(1447-1449)GAA>CAA	p.E483Q	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Missense_Mutation_p.E478Q|ZNF250_uc010mgg.2_Missense_Mutation_p.E478Q	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	483	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		TTGCCACATTCTGTGCACTGG	0.552													7	41					0	0	0	0	G	146107136	G	G	146107136	3	3	192	1	0	0	0	0	1	0	0	0	17862	922	32	2	239	2	ZNF250	8	146107136	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	6505556	146107136	256886	67	35318											
ZNF250	58500	broad.mit.edu	37	chr8	146107269	146107269	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggactctctggtgctggatCaggtgtgagtgctgaacgaa	8	11	15	7	1	2	2	1	2	1	0	3	5	2	4	0	4	3	2	0	4	2	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr8:146107269C>G	uc003zeq.3	-	6	1431	c.1314G>C	c.(1312-1314)CTG>CTC	p.L438L	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Silent_p.L433L|ZNF250_uc010mgg.2_Silent_p.L433L	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	438	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		GGTGCTGGATCAGGTGTGAGT	0.567													11	62					0	0	0	0	G	146107269	G	G	146107269	2	3	192	1	0	0	0	0	0	0	0	1	17862	813	29	2		2	ZNF250	8	146107269	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08	133	146107269	256753	68	35319											
APBA1	320	broad.mit.edu	37	chr9	72131553	72131553	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacacgtgctcctggaggcCgccgtagtcggcatagggct	6	8	15	12	4	0	0	0	0	0	0	2	1	1	1	3	4	2	5	3	4	3	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr9:72131553C>T	uc004ahh.2	-	2	850	c.574G>A	c.(574-576)GGC>AGC	p.G192S		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	192					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						TCCTGGAGGCCGCCGTAGTCG	0.687													5	26					0	0	0	0	T	72131553	T	T	72131553	3	4	192	1	0	0	0	0	1	0	0	0	756	652	23	1	1987	1	APBA1	9	72131553	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08		72131553	69081878	69	35320											
SYK	6850	broad.mit.edu	37	chr9	93650902	93650902	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcatgaatctgtgctggAcatacgagtgagtacctgac	11	11	10	9	1	2	3	1	3	2	0	3	5	2	4	1	1	3	2	1	1	3	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr9:93650902A>G	uc004aqz.2	+	13	2033	c.1828A>G	c.(1828-1830)ACA>GCA	p.T610A	SYK_uc004ara.2_Missense_Mutation_p.T587A|SYK_uc004arb.2_Missense_Mutation_p.T587A|SYK_uc004arc.2_Missense_Mutation_p.T610A|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	610	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						TCTGTGCTGGACATACGAGTG	0.463			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								7	18					0	0	0	0	G	93650902	G	G	93650902	3	3	192	1	0	0	0	0	1	0	0	0	15504	275	10	5	1874	5	SYK	9	93650902	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	21519349	93650902	47562529	70	35321											
PAPPA	5069	broad.mit.edu	37	chr9	118997917	118997917	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aataggaaattcgtagacatGtaagtgcattctctgaatag	15	12	9	5	1	1	2	0	1	1	1	3	3	1	3	0	1	1	3	0	1	7	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr9:118997917G>T	uc004bjn.2	+	7	3113	c.2732_splice	c.e7+1	p.M911_splice	PAPPA_uc011lxp.1_Splice_Site_p.M606_splice|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A						cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TCGTAGACATGTAAGTGCATT	0.507													42	103					5.2432e-18	3.03964e-17	1	0	T	118997917	T	T	118997917	5	4	192	1	0	0	0	0	0	0	1	0	11486	1391	48	4	2759	4	PAPPA	9	118997917	Splice_Site	SNP	G	TCGA-CV-6933-01A-11D-1912-08	25347015	118997917	22215514	71	35322											
BAT2L1	84726	broad.mit.edu	37	chr9	134343088	134343088	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccctgcacaggagttcaagtAtcagaagtcccttcctcccc	9	9	7	16	0	2	1	2	0	0	1	5	2	5	2	5	1	1	3	5	1	3	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr9:134343088A>G	uc004can.3	+	12	1914	c.1859A>G	c.(1858-1860)TAT>TGT	p.Y620C	BAT2L1_uc010mzj.1_Missense_Mutation_p.Y203C	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	620	Gln-rich.						protein binding				0						GAGTTCAAGTATCAGAAGTCC	0.557													20	45					0	0	0	0	G	134343088	G	G	134343088	3	3	192	1	0	0	0	0	1	0	0	0	1322	449	16	5	1905	5	BAT2L1	9	134343088	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	15345171	134343088	6870343	72	35323											
NMT2	9397	broad.mit.edu	37	chr10	15151773	15151773	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgccatctcctataccaaaCttgagtttttccaagaatgt	11	15	5	10	0	1	2	0	1	1	1	3	2	2	2	4	0	3	1	4	0	5	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr10:15151773C>G	uc001inz.1	-	11	1488	c.1404G>C	c.(1402-1404)AAG>AAC	p.K468N	NMT2_uc001ioa.1_Missense_Mutation_p.K455N|NMT2_uc009xjo.1_Intron|NMT2_uc010qbz.1_Missense_Mutation_p.K280N	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	468					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						CTATACCAAACTTGAGTTTTT	0.328													14	91					0	0	0	0	G	15151773	G	G	15151773	3	3	192	1	0	0	0	0	1	0	0	0	10558	564	20	4	100	4	NMT2	10	15151773	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08		15151773	120382974	73	35324											
SH2D4B	387694	broad.mit.edu	37	chr10	82363350	82363350	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtgcgccggtccaaggCggctgatgaggagaggagcc	8	5	17	11	3	0	3	0	2	0	1	2	5	2	4	4	5	2	1	4	5	1	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr10:82363350C>T	uc001kck.1	+	5	1089	c.659C>T	c.(658-660)GCG>GTG	p.A220V	SH2D4B_uc001kcl.1_Missense_Mutation_p.A171V|SH2D4B_uc001kcm.1_5'UTR	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	219	Glu-rich.										0			Colorectal(32;0.229)			CGGTCCAAGGCGGCTGATGAG	0.642													5	2					0	0	0	0	T	82363350	T	T	82363350	3	4	192	1	0	0	0	0	1	0	0	0	14301	768	27	1	718	1	SH2D4B	10	82363350	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	67211577	82363350	53171397	74	35325											
OR52A4	390053	broad.mit.edu	37	chr11	5142746	5142746	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtacagattcaaaaccgggGatcccaataaatgtcagcac	15	8	8	10	1	2	1	2	0	0	1	3	2	3	2	2	2	3	2	2	2	6	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:5142746G>A	uc001lzz.1	-	1	63	c.63C>T	c.(61-63)ATC>ATT	p.I21I	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAAAACCGGGGATCCCAATAA	0.418													24	119					0	0	0	0	A	5142746	A	A	5142746	2	1	192	1	0	0	0	0	0	0	0	1	11163	1164	41	2		2	OR52A4	11	5142746	Silent	SNP	G	TCGA-CV-6933-01A-11D-1912-08		5142746	129863770	75	35326											
OR5F1	338674	broad.mit.edu	37	chr11	55761646	55761646	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgaccatgaagttcagcaaCcctgcagcaaaagccccggc	12	6	9	14	1	1	2	1	2	0	0	1	2	1	2	4	1	5	4	4	1	4	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:55761646C>A	uc010riv.1	-	1	456	c.456G>T	c.(454-456)GGG>GGT	p.G152G		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					AGTTCAGCAACCCTGCAGCAA	0.507													11	60					9.70103e-10	5.40486e-09	1	0	A	55761646	A	A	55761646	2	1	192	1	0	0	0	0	0	0	0	1	11212	494	18	4		4	OR5F1	11	55761646	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08	50618900	55761646	79244870	76	35327											
GLYATL1	92292	broad.mit.edu	37	chr11	58723492	58723492	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gctacccacagaatctagttCcattttagacaatgaagctg	13	11	7	10	0	1	3	0	1	1	2	2	3	2	3	2	0	2	3	2	0	6	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:58723492C>G	uc001nnf.2	+	8	1277	c.901C>G	c.(901-903)CCA>GCA	p.P301A	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.P332A|GLYATL1_uc001nni.1_Missense_Mutation_p.P301A|GLYATL1_uc001nnj.1_Missense_Mutation_p.P301A			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	301						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	GAATCTAGTTCCATTTTAGAC	0.388													3	86					0	0	0	0	G	58723492	G	G	58723492	3	3	192	1	0	0	0	0	1	0	0	0	6517	855	30	2	1020	2	GLYATL1	11	58723492	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	2961846	58723492	76283024	77	35328											
POLR2G	5436	broad.mit.edu	37	chr11	62532822	62532822	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctttcagtccatcccttCagagatggagtttgatccta	8	15	7	11	0	2	2	2	1	0	1	6	4	6	3	4	1	0	1	4	1	1	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:62532822C>T	uc001nva.2	+	5	454	c.344C>T	c.(343-345)TCA>TTA	p.S115L	POLR2G_uc001nvb.2_RNA	NM_002696	NP_002687	P62487	RPB7_HUMAN	DNA directed RNA polymerase II polypeptide G	115					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|protein binding|RNA binding				0						TCCATCCCTTCAGAGATGGAG	0.458													28	288					0	0	0	0	T	62532822	T	T	62532822	3	4	192	1	0	0	0	0	1	0	0	0	12275	838	29	2	362	2	POLR2G	11	62532822	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	3809330	62532822	72473694	78	35329											
NXF1	10482	broad.mit.edu	37	chr11	62569082	62569082	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagggcttgttgggagccatCgtatcgtttgctcatgatca	8	13	12	8	2	2	1	2	1	0	0	4	2	2	2	1	2	2	5	1	2	2	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:62569082C>T	uc001nvf.1	-	7	797	c.661G>A	c.(661-663)GAT>AAT	p.D221N	NXF1_uc001nvg.1_Missense_Mutation_p.D221N|NXF1_uc009yog.1_Missense_Mutation_p.D264N|NXF1_uc010rmh.1_Missense_Mutation_p.D84N	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	221	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						TGGGAGCCATCGTATCGTTTG	0.507													18	170					0	0	0	0	T	62569082	T	T	62569082	3	4	192	1	0	0	0	0	1	0	0	0	10836	884	31	1	1313	1	NXF1	11	62569082	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	36260	62569082	72437434	79	35330											
EHD1	10938	broad.mit.edu	37	chr11	64627443	64627443	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcattgagcttcctgagggCggcgtttcggggcagtgact	5	11	16	9	3	1	3	1	3	0	0	3	3	2	3	1	4	1	3	1	4	0	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:64627443C>A	uc001obu.1	-	3	1123	c.868G>T	c.(868-870)GCC>TCC	p.A290S	EHD1_uc001obv.1_Missense_Mutation_p.A290S|EHD1_uc010rnq.1_Missense_Mutation_p.A304S	NM_006795	NP_006786	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	290					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding				0						TTCCTGAGGGCGGCGTTTCGG	0.637													46	32					3.21987e-24	1.90528e-23	1	0	A	64627443	A	A	64627443	3	1	192	1	0	0	0	0	1	0	0	0	4999	768	27	3	748	3	EHD1	11	64627443	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	2058361	64627443	70379073	80	35331											
ALKBH8	91801	broad.mit.edu	37	chr11	107431547	107431547	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcagcaaagtatgcttggCtttaatctgtttccttaaga	10	16	7	8	0	2	1	1	0	2	1	4	1	3	1	1	1	2	5	1	1	4	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:107431547C>T	uc010rvr.1	-	2	148	c.73G>A	c.(73-75)GCC>ACC	p.A25T	ALKBH8_uc009yxp.2_Missense_Mutation_p.A25T|ALKBH8_uc001pjl.2_RNA	NM_138775	NP_620130	Q96BT7	ALKB8_HUMAN	alkB, alkylation repair homolog 8	25					response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)		GTATGCTTGGCTTTAATCTGT	0.348													13	29					0	0	0	0	T	107431547	T	T	107431547	3	4	192	1	0	0	0	0	1	0	0	0	533	797	28	4	1965	4	ALKBH8	11	107431547	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	42804104	107431547	27574969	81	35332											
OR4D5	219875	broad.mit.edu	37	chr11	123811175	123811175	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcacccccatgctgaatccTgccatctataccctgagaaa	11	9	6	15	0	2	2	1	2	1	1	3	3	3	2	5	0	3	1	5	0	4	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr11:123811175T>C	uc001pzk.1	+	1	852	c.852T>C	c.(850-852)CCT>CCC	p.P284P		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TGCTGAATCCTGCCATCTATA	0.502													22	86					0	0	0	0	C	123811175	C	C	123811175	2	2	192	1	0	0	0	0	0	0	0	1	11111	1567	55	5		5	OR4D5	11	123811175	Silent	SNP	T	TCGA-CV-6933-01A-11D-1912-08	16379628	123811175	11195341	82	35333											
C3AR1	719	broad.mit.edu	37	chr12	8211391	8211391	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgagggacagtgggtggaaCgtgtgagctcctcactgaag	9	9	16	7	1	1	3	1	3	0	0	2	5	2	5	1	3	2	1	1	3	2	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:8211391C>T	uc001qtv.1	-	2	1483	c.1391G>A	c.(1390-1392)CGT>CAT	p.R464H		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	464	Cytoplasmic (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		GTGGGTGGAACGTGTGAGCTC	0.473													34	91					0	0	0	0	T	8211391	T	T	8211391	3	4	192	1	0	0	0	0	1	0	0	0	2215	536	19	1	61	1	C3AR1	12	8211391	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08		8211391	125640504	83	35334											
PHC1	1911	broad.mit.edu	37	chr12	9092018	9092018	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caagctgggccctgccctcaAgatctgcgccaagataaatg	11	7	10	13	1	2	2	1	0	1	2	2	2	2	2	3	1	3	1	3	1	5	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:9092018A>T	uc001qvd.2	+	15	3134	c.2978A>T	c.(2977-2979)AAG>ATG	p.K993M	PHC1_uc001qve.2_Missense_Mutation_p.K993M	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	993	SAM.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						CCTGCCCTCAAGATCTGCGCC	0.488													13	14					0	0	0	0	T	9092018	T	T	9092018	3	4	192	1	0	0	0	0	1	0	0	0	11871	72	3	5	3032	5	PHC1	12	9092018	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	880627	9092018	124759877	84	35335											
PZP	5858	broad.mit.edu	37	chr12	9353588	9353588	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctctgatgagaggggaaaGgacaactgattgatgccagc	12	7	15	7	0	1	4	0	4	1	1	1	7	1	6	1	4	3	1	1	4	2	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:9353588G>C	uc001qvl.2	-	6	599	c.570C>G	c.(568-570)TCC>TCG	p.S190S	PZP_uc009zgl.2_Silent_p.S59S	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AGAGGGGAAAGGACAACTGAT	0.498													27	130					0	0	0	0	C	9353588	C	C	9353588	2	2	192	1	0	0	0	0	0	0	0	1	12934	987	35	4		4	PZP	12	9353588	Silent	SNP	G	TCGA-CV-6933-01A-11D-1912-08	261570	9353588	124498307	85	35336											
PRB4	5545	broad.mit.edu	37	chr12	11461798	11461798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggtttcctccttgtgggCgtcgtccttctggctttcct	0	17	11	13	2	1	0	0	0	1	0	6	0	5	0	4	3	0	3	4	3	0	4	rs77336955		TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:11461798C>T	uc001qzf.1	-	3	153	c.119G>A	c.(118-120)CGC>CAC	p.R40H	PRB4_uc001qzt.2_Missense_Mutation_p.R40H	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	40	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|1.					extracellular region				ovary(1)	1						TCCTTGTGGGCGTCGTCCTTC	0.552										HNSCC(22;0.051)			33	444					0	0	0	0	T	11461798	T	T	11461798	3	4	192	1	0	0	0	0	1	0	0	0	12507	768	27	1	628	1	PRB4	12	11461798	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	2108210	11461798	122390097	86	35337											
DNM1L	10059	broad.mit.edu	37	chr12	32886735	32886735	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgggctaatgaacaataaTatagaggtaaatataattct	17	13	8	3	0	1	2	0	1	1	1	1	2	1	2	0	2	1	2	0	2	10	8			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:32886735T>C	uc001rld.2	+	13	1694	c.1533T>C	c.(1531-1533)AAT>AAC	p.N511N	DNM1L_uc001rle.2_Silent_p.N511N|DNM1L_uc001rlf.2_Silent_p.N511N|DNM1L_uc010skh.1_Silent_p.N577N|DNM1L_uc001rlg.2_Silent_p.N577N|DNM1L_uc001rlh.2_Silent_p.N564N|DNM1L_uc010ski.1_Silent_p.N308N	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	511	Interaction with GSK3B.|B domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGAACAATAATATAGAGGTAA	0.303													53	148					0	0	0	0	C	32886735	C	C	32886735	2	2	192	1	0	0	0	0	0	0	0	1	4693	1403	49	5		5	DNM1L	12	32886735	Silent	SNP	T	TCGA-CV-6933-01A-11D-1912-08	21424937	32886735	100965160	87	35338											
SFRS2IP	9169	broad.mit.edu	37	chr12	46315837	46315837	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagcgttccccatttcagccTatgtttttttcagtagacac	8	15	6	12	1	2	1	2	0	0	1	3	1	3	1	3	0	2	3	3	0	2	7			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:46315837T>C	uc001rox.2	-	15	4673	c.4386A>G	c.(4384-4386)ATA>ATG	p.I1462M	SFRS2IP_uc001row.2_Missense_Mutation_p.I1147M	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1462					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		CATTTCAGCCTATGTTTTTTT	0.378													3	148					0	0	0	0	C	46315837	C	C	46315837	3	2	192	1	0	0	0	0	1	0	0	0	14242	1512	53	5	9	5	SFRS2IP	12	46315837	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	13429102	46315837	87536058	88	35339											
OR6C1	390321	broad.mit.edu	37	chr12	55714812	55714812	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagtctgcacactgcttgtTtttacttcttggctggtttc	5	18	9	9	0	2	1	0	0	2	1	3	1	2	1	0	2	3	5	0	2	1	7			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:55714812T>G	uc010spi.1	+	1	429	c.429T>G	c.(427-429)GTT>GTG	p.V143V		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						CACTGCTTGTTTTTACTTCTT	0.408													6	22					0	0	0	0	G	55714812	G	G	55714812	2	3	192	1	0	0	0	0	0	0	0	1	11244	1828	64	5		5	OR6C1	12	55714812	Silent	SNP	T	TCGA-CV-6933-01A-11D-1912-08	9398975	55714812	78137083	89	35340											
COQ10A	93058	broad.mit.edu	37	chr12	56663287	56663287	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcaaccacttagagactaTttggcgattcagccctggta	10	12	8	11	1	2	1	2	0	0	1	2	3	2	1	2	2	2	1	2	2	4	6			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:56663287T>C	uc001sko.3	+	4	779	c.518T>C	c.(517-519)ATT>ACT	p.I173T	COQ10A_uc001skp.3_Missense_Mutation_p.I141T|COQ10A_uc001skq.3_Missense_Mutation_p.I156T	NM_144576	NP_653177	Q96MF6	CQ10A_HUMAN	coenzyme Q10 homolog A isoform a	173						mitochondrial inner membrane				ovary(1)	1						TTAGAGACTATTTGGCGATTC	0.438													22	143					0	0	0	0	C	56663287	C	C	56663287	3	2	192	1	0	0	0	0	1	0	0	0	3758	1493	52	5	574	5	COQ10A	12	56663287	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	948475	56663287	77188608	90	35341											
LEMD3	23592	broad.mit.edu	37	chr12	65564805	65564805	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccactacttgtcgatgtttCtcttaactgctgcctgctta	6	16	6	13	1	1	0	0	0	1	0	3	1	1	0	2	0	5	3	2	0	3	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:65564805C>G	uc001ssl.1	+	1	1435	c.1429C>G	c.(1429-1431)CTC>GTC	p.L477V	LEMD3_uc009zqo.1_Missense_Mutation_p.L477V	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	477	Helical; (Potential).				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GTCGATGTTTCTCTTAACTGC	0.478													23	38					0	0	0	0	G	65564805	G	G	65564805	3	3	192	1	0	0	0	0	1	0	0	0	8761	913	32	2	1431	2	LEMD3	12	65564805	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	8901518	65564805	68287090	91	35342											
PPFIA2	8499	broad.mit.edu	37	chr12	81777935	81777935	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgttctttcatctgggccAtttcatagttttgcttttca	7	19	6	9	1	5	0	3	0	2	0	5	0	5	0	1	1	2	3	1	1	2	8			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:81777935A>T	uc001szo.1	-	9	1012	c.851T>A	c.(850-852)ATG>AAG	p.M284K	PPFIA2_uc010sue.1_Missense_Mutation_p.M184K|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	210										ovary(3)|lung(2)|pancreas(1)	6						CATCTGGGCCATTTCATAGTT	0.413													10	25					0	0	0	0	T	81777935	T	T	81777935	3	4	192	1	0	0	0	0	1	0	0	0	12365	217	8	5	3018	5	PPFIA2	12	81777935	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	16213130	81777935	52073960	92	35343											
TMTC3	160418	broad.mit.edu	37	chr12	88589416	88589416	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agagattgaacgtattttaaAtggtgaataacattaatatt	17	15	7	2	1	0	3	0	2	0	1	0	4	0	3	0	1	2	1	0	1	8	8			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:88589416A>G	uc001tau.2	+	14	2955	c.2735A>G	c.(2734-2736)AAT>AGT	p.N912S		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	913						integral to membrane	binding			skin(1)	1						CGTATTTTAAATGGTGAATAA	0.333													12	50					0	0	0	0	G	88589416	G	G	88589416	3	3	192	1	0	0	0	0	1	0	0	0	16328	101	4	5	2785	5	TMTC3	12	88589416	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	6811481	88589416	45262479	93	35344											
TXNRD1	7296	broad.mit.edu	37	chr12	104732985	104732985	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acacaaggctttgcagctgcGctcaaatgtggactgaccaa	12	8	10	11	1	1	1	1	1	0	0	1	2	1	2	1	2	3	4	1	2	3	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr12:104732985G>A	uc010swk.1	+	16	1837	c.1815G>A	c.(1813-1815)GCG>GCA	p.A605A	TXNRD1_uc010swl.1_Silent_p.A455A|TXNRD1_uc010swm.1_Silent_p.A507A|TXNRD1_uc010swn.1_Silent_p.A455A|TXNRD1_uc010swo.1_Silent_p.A455A|TXNRD1_uc010swp.1_Silent_p.A417A|TXNRD1_uc010swq.1_Silent_p.A505A|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Silent_p.A521A	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	605					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						TTGCAGCTGCGCTCAAATGTG	0.433													9	29					0	0	0	0	A	104732985	A	A	104732985	2	1	192	1	0	0	0	0	0	0	0	1	16875	1074	38	1		1	TXNRD1	12	104732985	Silent	SNP	G	TCGA-CV-6933-01A-11D-1912-08	16143569	104732985	29118910	94	35345											
ZCCHC8	55596	broad.mit.edu	37	chr12	122958362	122958362	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgacaaagtgatgtcacCtcagagtctggactggaggc	10	10	12	9	0	4	3	2	2	2	1	4	5	4	5	1	3	0	0	1	3	1	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	6107e303-4ebb-4f5e-a281-c3eebba0966b	g.chr12:122958362C>A	uc001ucn.2	-	14	1937	c.1806G>T	c.(1804-1806)GAG>GAT	p.E602D	ZCCHC8_uc001ucl.2_Missense_Mutation_p.E213D|ZCCHC8_uc001ucm.2_Missense_Mutation_p.E364D|ZCCHC8_uc009zxp.2_Missense_Mutation_p.E364D|ZCCHC8_uc009zxq.2_Missense_Mutation_p.E364D	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	602						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		GTGATGTCACCTCAGAGTCTG	0.463													7	250					0.00198382	0.00679821	1	0	A	122958362	A	A	122958362	3	1	192	1	0	0	0	0	1	0	0	0	17661	680	24	4	321	4	ZCCHC8	12	122958362	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	18225377	122958362	10893533	95	35346											
SACS	26278	broad.mit.edu	37	chr13	23910945	23910945	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaatgaaaagaaacctttTctgagtcaacatatgcattc	16	13	5	7	0	2	3	1	2	1	1	3	3	2	3	1	0	3	1	1	0	7	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:23910945T>A	uc001uon.2	-	10	7659	c.7070A>T	c.(7069-7071)GAA>GTA	p.E2357V	SACS_uc001uoo.2_Missense_Mutation_p.E2210V|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2357					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AGAAACCTTTTCTGAGTCAAC	0.333													25	50					0	0	0	0	A	23910945	A	A	23910945	3	1	192	1	0	0	0	0	1	0	0	0	13869	1783	62	5	6673	5	SACS	13	23910945	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08		23910945	91258933	96	35347											
FOXO1	2308	broad.mit.edu	37	chr13	41134865	41134865	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actgttgttgtccatggatgCagctcttctcctaggagatt	7	15	10	9	0	2	1	0	0	2	1	4	3	3	2	2	2	2	4	2	2	1	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:41134865C>T	uc001uxl.3	-	2	1148	c.763G>A	c.(763-765)GCA>ACA	p.A255T	FOXO1_uc010acc.1_Missense_Mutation_p.A70T	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	255					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TCCATGGATGCAGCTCTTCTC	0.517													18	149					0	0	0	0	T	41134865	T	T	41134865	3	4	192	1	0	0	0	0	1	0	0	0	6057	710	25	4	1208	4	FOXO1	13	41134865	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	17223920	41134865	74035013	97	35348											
TSC22D1	8848	broad.mit.edu	37	chr13	45148997	45148997	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttcacaactctgaacctcGaagtgttaactgttggttgt	10	14	8	9	1	2	1	1	1	1	0	3	2	2	1	1	1	3	3	1	1	4	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:45148997G>A	uc001uzn.3	-	1	1705	c.1214C>T	c.(1213-1215)TCG>TTG	p.S405L	TSC22D1_uc001uzo.1_Missense_Mutation_p.S405L	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	405					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TCTGAACCTCGAAGTGTTAAC	0.438													25	83					0	0	0	0	A	45148997	A	A	45148997	3	1	192	1	0	0	0	0	1	0	0	0	16674	1059	37	1	2148	1	TSC22D1	13	45148997	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	4014132	45148997	70020881	98	35349											
OLFM4	10562	broad.mit.edu	37	chr13	53608558	53608558	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttccctgccagacaccaccTttcccgtggacagagtggaa	9	9	9	14	1	0	2	0	0	0	2	2	4	2	4	5	2	1	0	5	2	1	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:53608558T>A	uc001vhl.2	+	2	280	c.280T>A	c.(280-282)TTT>ATT	p.F94I	OLFM4_uc001vhk.1_Missense_Mutation_p.F94I	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	94					cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		AGACACCACCTTTCCCGTGGA	0.443													10	84					0	0	0	0	A	53608558	A	A	53608558	3	1	192	1	0	0	0	0	1	0	0	0	10909	1609	56	5	286	5	OLFM4	13	53608558	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	8459561	53608558	61561320	99	35350											
DIAPH3	81624	broad.mit.edu	37	chr13	60413536	60413536	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccttctcaagctgttgaagCtgccttcccatctgcctcaa	7	13	6	15	0	3	1	2	1	2	0	6	1	5	1	4	0	4	3	4	0	3	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:60413536C>A	uc001vht.2	-	23	3003	c.2784G>T	c.(2782-2784)CAG>CAT	p.Q928H	DIAPH3_uc001vhu.2_Missense_Mutation_p.Q665H	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	928	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GCTGTTGAAGCTGCCTTCCCA	0.383													16	38					1.15088e-07	6.37066e-07	1	0	A	60413536	A	A	60413536	3	1	192	1	0	0	0	0	1	0	0	0	4542	796	28	4	841	4	DIAPH3	13	60413536	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	6804978	60413536	54756342	100	35351											
SLITRK1	114798	broad.mit.edu	37	chr13	84455394	84455394	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatgtgcaaactaaccgcAttataaaagttagcgaactc	15	10	6	10	2	0	0	0	0	0	0	2	1	1	0	2	0	5	3	2	0	7	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:84455394A>T	uc001vlk.2	-	1	1135	c.249T>A	c.(247-249)AAT>AAA	p.N83K		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	83	Extracellular (Potential).|LRR 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AACTAACCGCATTATAAAAGT	0.463													31	65					0	0	0	0	T	84455394	T	T	84455394	3	4	192	1	0	0	0	0	1	0	0	0	14806	214	8	5	1845	5	SLITRK1	13	84455394	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	24041858	84455394	30714484	101	35352											
COL4A2	1284	broad.mit.edu	37	chr13	111102707	111102707	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagggcttcatcggagacccCggcatccctgcgctctacgg	7	7	12	15	4	2	1	1	0	1	1	4	2	3	1	3	4	2	3	3	4	2	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr13:111102707C>G	uc001vqx.2	+	20	1534	c.1245C>G	c.(1243-1245)CCC>CCG	p.P415P		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	415	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			TCGGAGACCCCGGCATCCCTG	0.637													3	81					0	0	0	0	G	111102707	G	G	111102707	2	3	192	1	0	0	0	0	0	0	0	1	3705	639	23	3		3	COL4A2	13	111102707	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08	26647313	111102707	4067171	102	35353											
NID2	22795	broad.mit.edu	37	chr14	52520462	52520462	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggccctccatctgggtaggGctggatgcttccgttttcgg	3	13	14	11	2	1	0	0	0	1	0	4	1	3	1	3	5	1	4	3	5	1	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr14:52520462G>T	uc001wzo.2	-	5	1498	c.1264C>A	c.(1264-1266)CCC>ACC	p.P422T	NID2_uc010tqs.1_Missense_Mutation_p.P422T|NID2_uc010tqt.1_Missense_Mutation_p.P422T|NID2_uc001wzp.2_Missense_Mutation_p.P422T	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	422						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TCTGGGTAGGGCTGGATGCTT	0.552													23	59					1.10513e-12	6.2795e-12	1	0	T	52520462	T	T	52520462	3	4	192	1	0	0	0	0	1	0	0	0	10469	1203	42	4	2935	4	NID2	14	52520462	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08		52520462	54829078	103	35354											
SYNE2	23224	broad.mit.edu	37	chr14	64468762	64468762	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggccatccagggatttcAtctcattgatgctgatcgca	10	12	9	10	1	2	2	2	2	1	0	5	3	3	3	2	2	1	2	2	2	1	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr14:64468762A>T	uc001xgm.2	+	29	3979	c.3749A>T	c.(3748-3750)CAT>CTT	p.H1250L	SYNE2_uc001xgl.2_Missense_Mutation_p.H1250L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1250	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAGGGATTTCATCTCATTGAT	0.418													33	81					0	0	0	0	T	64468762	T	T	64468762	3	4	192	1	0	0	0	0	1	0	0	0	15512	217	8	5	3859	5	SYNE2	14	64468762	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	11948300	64468762	42880778	104	35355											
C14orf179	112752	broad.mit.edu	37	chr14	76549919	76549919	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggcaggccaggcacacctGagcccgtcacccatgctcta	8	5	12	16	1	2	1	1	1	1	0	2	1	2	1	4	4	2	3	4	4	1	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr14:76549919G>C	uc010asm.1	+	9	660	c.626G>C	c.(625-627)TGA>TCA	p.*209S	C14orf179_uc001xsg.2_Nonstop_Mutation_p.*214S|C14orf179_uc010tve.1_RNA	NM_001102564	NP_001096034	Q96FT9	IFT43_HUMAN	hypothetical protein LOC112752 isoform 2	209					cilium morphogenesis|intraflagellar retrograde transport						0				BRCA - Breast invasive adenocarcinoma(234;0.0199)		AGGCACACCTGAGCCCGTCAC	0.507													6	57					0	0	0	0	C	76549919	C	C	76549919	4	2	192	1	0	0	0	0	0	0	0	0	1768	1285	45	2	759	2	C14orf179	14	76549919	Nonstop_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	12081157	76549919	30799621	105	35356											
ESRRB	2103	broad.mit.edu	37	chr14	76957942	76957942	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgaggagcactcccgcCtcgcggggctgctggagctc	5	7	16	13	3	0	1	0	1	0	0	3	4	1	4	2	5	3	4	2	5	0	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr14:76957942C>T	uc001xsq.1	+	6	1007	c.940C>T	c.(940-942)CTC>TTC	p.L314F	ESRRB_uc001xsr.2_Missense_Mutation_p.L314F|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	314						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		GCACTCCCGCCTCGCGGGGCT	0.592													4	9					0	0	0	0	T	76957942	T	T	76957942	3	4	192	1	0	0	0	0	1	0	0	0	5285	681	24	4	958	4	ESRRB	14	76957942	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	408023	76957942	30391598	106	35357											
PTPN21	11099	broad.mit.edu	37	chr14	88945598	88945598	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcacgtgcaggaggcgccCgggccccgctctcctcctcg	3	5	14	19	6	1	0	0	0	1	0	4	1	2	1	5	3	1	3	5	3	0	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr14:88945598C>G	uc001xwv.3	-	13	2508	c.2177G>C	c.(2176-2178)CGG>CCG	p.R726P	PTPN21_uc010twc.1_Missense_Mutation_p.R522P	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	726						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						AGGAGGCGCCCGGGCCCCGCT	0.701													3	20					0	0	0	0	G	88945598	G	G	88945598	3	3	192	1	0	0	0	0	1	0	0	0	12851	652	23	3	1375	3	PTPN21	14	88945598	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	11987656	88945598	18403942	107	35358											
MAGEL2	54551	broad.mit.edu	37	chr15	23889583	23889583	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgggcctgtctaaataggAtgccaccaaattccctgtat	10	12	8	11	0	1	0	0	0	1	0	2	1	2	1	4	2	1	1	4	2	5	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr15:23889583A>G	uc001ywj.3	-	1	1593	c.1498T>C	c.(1498-1500)TCC>CCC	p.S500P		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TCTAAATAGGATGCCACCAAA	0.423													5	40					0	0	0	0	G	23889583	G	G	23889583	3	3	192	1	0	0	0	0	1	0	0	0	9242	333	12	5	446	5	MAGEL2	15	23889583	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08		23889583	78641809	108	35359											
NDN	4692	broad.mit.edu	37	chr15	23931584	23931584	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctggcccgggagccccaaaAgaactcgtattcgggcggct	8	6	14	13	4	0	1	0	0	0	1	2	2	0	2	3	4	2	3	3	4	4	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr15:23931584A>G	uc001ywk.2	-	1	867	c.781T>C	c.(781-783)TTT>CTT	p.F261L		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	261	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		GAGCCCCAAAAGAACTCGTAT	0.572									Prader-Willi_syndrome				5	56					0	0	0	0	G	23931584	G	G	23931584	3	3	192	1	0	0	0	0	1	0	0	0	10301	72	3	5	188	5	NDN	15	23931584	Missense_Mutation	SNP	A	TCGA-CV-6933-01A-11D-1912-08	42001	23931584	78599808	109	35360											
PYGO1	26108	broad.mit.edu	37	chr15	55838317	55838317	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtatcacagccccatacTgcagatgcttctgcagttaa	11	10	8	12	0	2	1	1	0	1	1	2	1	2	1	2	1	5	5	2	1	3	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr15:55838317T>A	uc010bfl.1	-	3	1220	c.1164A>T	c.(1162-1164)GCA>GCT	p.A388A	PYGO1_uc002adf.1_Silent_p.A388A	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	388	PHD-type.				Wnt receptor signaling pathway	nucleus	zinc ion binding			ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		AGCCCCATACTGCAGATGCTT	0.448													25	60					0	0	0	0	A	55838317	A	A	55838317	2	1	192	1	0	0	0	0	0	0	0	1	12928	1567	55	5		5	PYGO1	15	55838317	Silent	SNP	T	TCGA-CV-6933-01A-11D-1912-08	31906733	55838317	46693075	110	35361											
LRRC28	123355	broad.mit.edu	37	chr15	99901641	99901641	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggtgaaggccatagggacgGagcatgatcacgtcctccct	10	7	13	11	2	1	2	1	2	0	0	3	4	3	4	3	4	1	1	3	4	2	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr15:99901641G>A	uc002bva.1	+	8	951	c.796G>A	c.(796-798)GAG>AAG	p.E266K	LRRC28_uc010urs.1_RNA|LRRC28_uc002bvb.1_Missense_Mutation_p.E112K|LRRC28_uc010urt.1_Missense_Mutation_p.E80K|LRRC28_uc002bvc.1_Missense_Mutation_p.E266K|LRRC28_uc010uru.1_Missense_Mutation_p.E197K|LRRC28_uc002bvd.1_Intron	NM_144598	NP_653199	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	266											0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			CATAGGGACGGAGCATGATCA	0.522											OREG0023509	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	63					0	0	0	0	A	99901641	A	A	99901641	3	1	192	1	0	0	0	0	1	0	0	0	9032	1175	41	2	822	2	LRRC28	15	99901641	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	44063324	99901641	2629751	111	35362											
SMG1	23049	broad.mit.edu	37	chr16	18875116	18875116	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgctttatttcctaaataaTttataacctcaggggaagag	14	14	7	6	0	1	1	1	0	0	1	2	2	2	2	2	2	2	1	2	2	7	8			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr16:18875116T>C	uc002dfm.2	-	25	3914	c.3551A>G	c.(3550-3552)AAT>AGT	p.N1184S	SMG1_uc010bwb.2_Missense_Mutation_p.N1044S	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1184	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TCCTAAATAATTTATAACCTC	0.403													13	36					0	0	0	0	C	18875116	C	C	18875116	3	2	192	1	0	0	0	0	1	0	0	0	14859	1493	52	5	7590	5	SMG1	16	18875116	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08		18875116	71479637	112	35363											
CHST4	10164	broad.mit.edu	37	chr16	71570812	71570812	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggagcccgcctggcacGtgtggatgaccttcaagcag	8	8	14	11	2	1	2	1	2	0	0	1	4	1	4	3	3	2	2	3	3	1	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr16:71570812G>A	uc002fan.2	+	2	413	c.232G>A	c.(232-234)GTG>ATG	p.V78M	CHST4_uc002fao.2_Missense_Mutation_p.V78M	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	78	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						CGCCTGGCACGTGTGGATGAC	0.577													30	62					0	0	0	0	A	71570812	A	A	71570812	3	1	192	1	0	0	0	0	1	0	0	0	3421	1145	40	1	234	1	CHST4	16	71570812	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	52695696	71570812	18783941	113	35364											
OR1A2	26189	broad.mit.edu	37	chr17	3101177	3101177	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctgcaatggcatacgatcGagctgtggccatcagctgcc	8	8	13	12	2	1	0	1	0	0	0	2	2	1	0	2	3	5	5	2	3	2	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr17:3101177G>A	uc002fvd.1	+	1	365	c.365G>A	c.(364-366)CGA>CAA	p.R122Q		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GCATACGATCGAGCTGTGGCC	0.483													32	60					0	0	0	0	A	3101177	A	A	3101177	3	1	192	1	0	0	0	0	1	0	0	0	11004	1058	37	1	367	1	OR1A2	17	3101177	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08		3101177	78094033	114	35365											
TP53	7157	broad.mit.edu	37	chr17	7578275	7578275	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccactcggataagatgctGaggaggggccagacctaaga	12	7	13	9	1	0	4	0	1	0	3	2	6	1	6	3	4	1	1	3	4	2	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	21					0	0	0	0	A	7578275	A	A	7578275	4	1	192	1	0	0	0	0	0	1	0	0	16448	1299	45	2	720	2	TP53	17	7578275	Nonsense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	4477098	7578275	73616935	115	35366											
KDM6B	23135	broad.mit.edu	37	chr17	7752094	7752094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagctgtttccacccggcctGggcccttgcccaccactcag	5	8	9	19	1	1	0	1	0	0	0	2	0	2	0	6	2	2	2	6	2	0	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr17:7752094G>A	uc002giw.1	+	11	2864	c.2488G>A	c.(2488-2490)GGG>AGG	p.G830R	KDM6B_uc002gix.2_Missense_Mutation_p.G132R	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	830	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CACCCGGCCTGGGCCCTTGCC	0.657													9	131					0	0	0	0	A	7752094	A	A	7752094	3	1	192	1	0	0	0	0	1	0	0	0	8177	1348	47	4	2518	4	KDM6B	17	7752094	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	173819	7752094	73443116	116	35367											
ICAM2	3384	broad.mit.edu	37	chr17	62081229	62081229	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagagggtgaggctgtccaGgggctccacggtgggcaccc	7	5	18	11	1	0	2	0	1	0	1	2	3	2	2	3	6	0	3	3	6	1	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr17:62081229G>T	uc002jdu.3	-	3	656	c.424C>A	c.(424-426)CTG>ATG	p.L142M	C17orf72_uc002jdt.3_3'UTR|C17orf72_uc010wpu.1_3'UTR|C17orf72_uc010wpv.1_3'UTR|C17orf72_uc010wpw.1_3'UTR|ICAM2_uc002jdw.3_Missense_Mutation_p.L142M|ICAM2_uc010ded.2_Missense_Mutation_p.L142M|ICAM2_uc002jdx.3_Missense_Mutation_p.L142M|ICAM2_uc002jdv.3_Missense_Mutation_p.L142M	NM_000873	NP_000864	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2 precursor	142	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			ovary(1)	1						AGGCTGTCCAGGGGCTCCACG	0.607													7	45					0.000157383	0.000833549	1	0	T	62081229	T	T	62081229	3	4	192	1	0	0	0	0	1	0	0	0	7519	991	35	4	411	4	ICAM2	17	62081229	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	54329135	62081229	19113981	117	35368											
MAPK4	5596	broad.mit.edu	37	chr18	48252451	48252451	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaggacgagcccacctcaCaacaccccttccgcattgag	10	6	8	17	2	1	2	1	2	0	0	2	4	2	3	5	1	2	1	5	1	1	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr18:48252451C>T	uc002lev.2	+	5	1973	c.973C>T	c.(973-975)CAA>TAA	p.Q325*	MAPK4_uc010xdm.1_Nonsense_Mutation_p.Q114*|MAPK4_uc010doz.2_Intron	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	325					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GCCCACCTCACAACACCCCTT	0.582													36	31					0	0	0	0	T	48252451	T	T	48252451	4	4	192	1	0	0	0	0	0	1	0	0	9333	479	17	4	987	4	MAPK4	18	48252451	Nonsense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08		48252451	29824797	118	35369											
CDH19	28513	broad.mit.edu	37	chr18	64172067	64172067	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctaattatttgactgcacTgcagaaccaaacatgcatgc	13	10	6	12	0	0	2	0	1	0	1	0	2	0	2	2	0	6	3	2	0	4	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr18:64172067T>A	uc002lkc.1	-	12	2439	c.2301A>T	c.(2299-2301)GCA>GCT	p.A767A	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	767	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TTGACTGCACTGCAGAACCAA	0.368													18	19					0	0	0	0	A	64172067	A	A	64172067	2	1	192	1	0	0	0	0	0	0	0	1	3119	1567	55	5		5	CDH19	18	64172067	Silent	SNP	T	TCGA-CV-6933-01A-11D-1912-08	15919616	64172067	13905181	119	35370											
FBN3	84467	broad.mit.edu	37	chr19	8191467	8191467	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cggctctcctggatcttcagCcagcaggtgcccttggtgct	4	11	12	14	1	3	0	1	0	2	0	4	1	3	1	3	4	4	3	3	4	0	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:8191467C>T	uc002mjf.2	-	19	2460	c.2439G>A	c.(2437-2439)TGG>TGA	p.W813*		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	813	TB 4.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGATCTTCAGCCAGCAGGTGC	0.677													6	12					0	0	0	0	T	8191467	T	T	8191467	4	4	192	1	0	0	0	0	0	1	0	0	5736	740	26	4	6170	4	FBN3	19	8191467	Nonsense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08		8191467	50937516	120	35371											
OR10H2	26538	broad.mit.edu	37	chr19	15839701	15839701	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccacctacgcagtcctcaCgcccttcctcagccccatca	8	7	4	22	2	3	0	3	0	0	0	5	0	5	0	7	0	2	1	7	0	1	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:15839701C>T	uc002nbm.2	+	1	868	c.848C>T	c.(847-849)ACG>ATG	p.T283M		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GCAGTCCTCACGCCCTTCCTC	0.547													29	119					0	0	0	0	T	15839701	T	T	15839701	3	4	192	1	0	0	0	0	1	0	0	0	10960	536	19	1	850	1	OR10H2	19	15839701	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	7648234	15839701	43289282	121	35372											
MEF2B	100271849	broad.mit.edu	37	chr19	19260222	19260222	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcatcagcccgaacttcCgcttggtgaacgtcacctgg	7	11	9	14	3	4	1	3	1	1	0	5	2	5	1	3	2	3	1	3	2	2	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:19260222C>G	uc002nlm.2	-	3	185	c.71G>C	c.(70-72)CGG>CCG	p.R24P	MEF2B_uc002nln.2_Missense_Mutation_p.R71P|MEF2B_uc002nll.2_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc010xqo.1_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc010xqp.1_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc002nlo.2_Missense_Mutation_p.R24P|LOC729991-MEF2B_uc002nlp.2_Missense_Mutation_p.R24P|MEF2B_uc002nlk.2_Missense_Mutation_p.R24P	NM_001145785	NP_001139257			myocyte enhancer factor 2B isoform a											skin(1)	1			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)			CCCGAACTTCCGCTTGGTGAA	0.562													16	54					0	0	0	0	G	19260222	G	G	19260222	3	3	192	1	0	0	0	0	1	0	0	0	9509	652	23	3	1063	3	MEF2B	19	19260222	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	3420521	19260222	39868761	122	35373											
ZNF43	7594	broad.mit.edu	37	chr19	21990434	21990434	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttatgtttgaaaaagtttgaGgtgttgtcaaaatcactgtc	12	16	9	4	0	2	2	2	2	0	0	3	2	2	2	0	1	0	3	0	1	5	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:21990434G>A	uc002nqj.2	-	4	2535	c.2405C>T	c.(2404-2406)CCT>CTT	p.P802L	ZNF43_uc010ecv.2_Missense_Mutation_p.P796L|ZNF43_uc002nql.2_Missense_Mutation_p.P796L|ZNF43_uc002nqm.2_Missense_Mutation_p.P796L|ZNF43_uc002nqk.2_Missense_Mutation_p.P732L	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	802					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		AAAAGTTTGAGGTGTTGTCAA	0.313													9	43					0	0	0	0	A	21990434	A	A	21990434	3	1	192	1	0	0	0	0	1	0	0	0	17970	1000	35	4	28	4	ZNF43	19	21990434	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	2730212	21990434	37138549	123	35374											
NR1H2	7376	broad.mit.edu	37	chr19	50881485	50881485	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atgctgggccacgagctttgCcgtgtctgtggggacaaggc	6	9	16	10	2	1	0	0	0	1	0	1	2	1	1	2	4	3	2	2	4	1	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:50881485C>T	uc010enw.2	+	5	537	c.261C>T	c.(259-261)TGC>TGT	p.C87C	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Silent_p.C87C|NR1H2_uc002psa.3_Intron	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	87	Nuclear receptor.|NR C4-type.				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		ACGAGCTTTGCCGTGTCTGTG	0.637													5	161					0	0	0	0	T	50881485	T	T	50881485	2	4	192	1	0	0	0	0	0	0	0	1	10671	747	26	4		4	NR1H2	19	50881485	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08	28891051	50881485	8247498	124	35375											
CEACAM18	729767	broad.mit.edu	37	chr19	51984689	51984689	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccgtcaatgccagctcccTggtggagaacatggattctg	8	10	11	12	1	2	1	1	0	1	1	4	3	4	2	3	3	3	1	3	3	2	1			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr19:51984689T>C	uc002pwv.1	+	4	626	c.626T>C	c.(625-627)CTG>CCG	p.L209P		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	209						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GCCAGCTCCCTGGTGGAGAAC	0.507													27	23					0	0	0	0	C	51984689	C	C	51984689	3	2	192	1	0	0	0	0	1	0	0	0	3204	1580	55	5	640	5	CEACAM18	19	51984689	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	1103204	51984689	7144294	125	35376											
PLCB4	5332	broad.mit.edu	37	chr20	9364994	9364994	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccataacacttatctcactGgcagacagttcggcgggaag	11	8	10	12	2	1	1	1	0	1	1	3	2	1	2	1	3	1	2	1	3	3	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:9364994G>A	uc002wnf.2	+	13	1136	c.1000G>A	c.(1000-1002)GGC>AGC	p.G334S	PLCB4_uc010gbw.1_Missense_Mutation_p.G334S|PLCB4_uc010gbx.2_Missense_Mutation_p.G334S|PLCB4_uc002wne.2_Missense_Mutation_p.G334S|PLCB4_uc002wnh.2_Missense_Mutation_p.G181S	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	334	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TTATCTCACTGGCAGACAGTT	0.463													35	71					0	0	0	0	A	9364994	A	A	9364994	3	1	192	1	0	0	0	0	1	0	0	0	12085	1348	47	4	1042	4	PLCB4	20	9364994	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08		9364994	53660526	126	35377											
PLK1S1	55857	broad.mit.edu	37	chr20	21143094	21143094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccagtttcagaatactgtGaatctgaaaataagtggtct	14	13	8	6	0	3	3	1	2	2	1	3	3	3	3	1	1	2	1	1	1	7	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:21143094G>A	uc002wsb.2	+	5	1121	c.988G>A	c.(988-990)GAA>AAA	p.E330K	PLK1S1_uc010zsh.1_Missense_Mutation_p.E227K|PLK1S1_uc010zsi.1_Missense_Mutation_p.E197K|PLK1S1_uc010zsj.1_RNA|uc002wsc.2_Intron|PLK1S1_uc002wsd.2_RNA	NM_018474	NP_060944	Q2M2Z5	KIZ_HUMAN	polo-like kinase 1 substrate 1 isoform 1	330					spindle organization	centrosome	protein kinase binding				0						AGAATACTGTGAATCTGAAAA	0.468													8	20					0	0	0	0	A	21143094	A	A	21143094	3	1	192	1	0	0	0	0	1	0	0	0	12150	1291	45	2	1006	2	PLK1S1	20	21143094	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	11778100	21143094	41882426	127	35378											
NKX2-4	644524	broad.mit.edu	37	chr20	21377938	21377938	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcccccaggccgggtggcgCgccgtccatggcgccgctga	3	4	16	18	7	0	1	0	1	0	0	1	1	1	1	6	4	0	1	6	4	0	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:21377938C>T	uc010gcz.2	-	1	110	c.100G>A	c.(100-102)GCG>ACG	p.A34T		NM_033176	NP_149416	Q9H2Z4	NKX24_HUMAN	NK2 homeobox 4	34					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ccgggtggcgcgccgTCCATG	0.517													4	7					0	0	0	0	T	21377938	T	T	21377938	3	4	192	1	0	0	0	0	1	0	0	0	10506	768	27	1	972	1	NKX2-4	20	21377938	Missense_Mutation	SNP	C	TCGA-CV-6933-01A-11D-1912-08	234844	21377938	41647582	128	35379											
NINL	22981	broad.mit.edu	37	chr20	25459583	25459583	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgctgcaggtggctgtgaTgccgcagggccaggccacac	6	7	15	13	1	1	1	0	1	1	0	1	1	1	1	3	4	3	4	3	4	0	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:25459583T>C	uc002wux.1	-	16	2251	c.2177A>G	c.(2176-2178)CAT>CGT	p.H726R	NINL_uc010gdn.1_Missense_Mutation_p.H726R|NINL_uc010gdo.1_Missense_Mutation_p.H509R	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	726					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GTGGCTGTGATGCCGCAGGGC	0.582													33	73					0	0	0	0	C	25459583	C	C	25459583	3	2	192	1	0	0	0	0	1	0	0	0	10474	1464	51	5	2007	5	NINL	20	25459583	Missense_Mutation	SNP	T	TCGA-CV-6933-01A-11D-1912-08	4081645	25459583	37565937	129	35380											
GSS	2937	broad.mit.edu	37	chr20	33524591	33524591	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagccttcggtcttggtccaGagaccccttttcagagatat	8	12	9	12	1	2	2	1	0	1	2	4	4	3	2	4	2	1	0	4	2	1	5			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:33524591G>A	uc002xbg.2	-	8	822	c.742C>T	c.(742-744)CTG>TTG	p.L248L	GSS_uc010zun.1_Silent_p.L120L|GSS_uc010zuo.1_Silent_p.L137L|GSS_uc010zup.1_Silent_p.L179L|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_5'UTR	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	248					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	TCTTGGTCCAGAGACCCCTTT	0.473													43	226					0	0	0	0	A	33524591	A	A	33524591	2	1	192	1	0	0	0	0	0	0	0	1	6868	933	33	2		2	GSS	20	33524591	Silent	SNP	G	TCGA-CV-6933-01A-11D-1912-08	8065008	33524591	29500929	130	35381											
EEF1A2	1917	broad.mit.edu	37	chr20	62122079	62122079	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacccggcccacgggcaccGtgccaatgcctgcagagggg	7	3	14	17	3	0	1	0	0	0	1	0	1	0	1	6	4	3	2	6	4	1	0			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr20:62122079G>A	uc002yfd.1	-	5	883	c.782C>T	c.(781-783)ACG>ATG	p.T261M	EEF1A2_uc002yfe.1_Missense_Mutation_p.T261M|EEF1A2_uc010gkg.1_Missense_Mutation_p.T261M	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	261						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CACGGGCACCGTGCCAATGCC	0.647													18	41					0	0	0	0	A	62122079	A	A	62122079	3	1	192	1	0	0	0	0	1	0	0	0	4946	1145	40	1	621	1	EEF1A2	20	62122079	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	28597488	62122079	903441	131	35382											
ZDHHC8	29801	broad.mit.edu	37	chr22	20127041	20127041	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggacgacttccgggctccGctgtacaagaacgtggatgt	9	8	14	10	4	0	1	0	0	0	1	2	5	2	3	2	3	2	3	2	3	3	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chr22:20127041G>A	uc002zrq.2	+	3	373	c.267G>A	c.(265-267)CCG>CCA	p.P89P	ZDHHC8_uc002zrr.1_Silent_p.P89P|ZDHHC8_uc010gsa.2_5'UTR	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	89	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					TCCGGGCTCCGCTGTACAAGA	0.607													61	44					0	0	0	0	A	20127041	A	A	20127041	2	1	192	1	0	0	0	0	0	0	0	1	17688	1074	38	1		1	ZDHHC8	22	20127041	Silent	SNP	G	TCGA-CV-6933-01A-11D-1912-08		20127041	31177525	132	35383											
ASMT	438	broad.mit.edu	37	chrX	1752052	1752052	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tccccttccaggtggggctgGagctctggctaaggaatgca	7	9	14	11	0	1	0	0	0	1	0	3	2	3	2	3	6	2	4	3	6	2	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:1752052G>C	uc004cqd.2	+	8	801	c.656G>C	c.(655-657)GGA>GCA	p.G219A	ASMT_uc010ncy.2_Missense_Mutation_p.G219A|ASMT_uc004cqe.2_Intron	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	191					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTGGGGCTGGAGCTCTGGCT	0.537													39	172					0	0	0	0	C	1752052	C	C	1752052	3	2	192	1	0	0	0	0	1	0	0	0	1047	1174	41	2	682	2	ASMT	23	1752052	Missense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08		1752052	153518508	133	35384											
NLGN4X	57502	broad.mit.edu	37	chrX	5811511	5811511	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atactggaatatctcgttcaAgttgtgcaaatgaggaacga	14	11	10	6	2	2	1	1	1	1	0	3	4	2	3	0	2	3	3	0	2	6	4			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:5811511A>G	uc010ndh.2	-	6	2299	c.1798T>C	c.(1798-1800)TTG>CTG	p.L600L	NLGN4X_uc004crp.2_Silent_p.L620L|NLGN4X_uc004crq.2_Silent_p.L600L|NLGN4X_uc010ndi.2_Silent_p.L637L|NLGN4X_uc004crr.2_Silent_p.L600L|NLGN4X_uc010ndj.2_Silent_p.L600L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	600	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						ATCTCGTTCAAGTTGTGCAAA	0.483													49	38					0	0	0	0	G	5811511	G	G	5811511	2	3	192	1	0	0	0	0	0	0	0	1	10518	69	3	5		5	NLGN4X	23	5811511	Silent	SNP	A	TCGA-CV-6933-01A-11D-1912-08	4059459	5811511	149459049	134	35385											
FAM47B	170062	broad.mit.edu	37	chrX	34961338	34961338	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctgatgaccaagcatccCttggccatgtaccccaatct	10	9	7	15	0	1	2	0	2	1	0	2	2	2	2	5	1	3	3	5	1	3	2			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:34961338C>T	uc004ddi.1	+	1	408	c.390C>T	c.(388-390)CCC>CCT	p.P130P		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	130										ovary(3)|breast(1)	4						CCAAGCATCCCTTGGCCATGT	0.557													40	22					0	0	0	0	T	34961338	T	T	34961338	2	4	192	1	0	0	0	0	0	0	0	1	5602	668	24	4		4	FAM47B	23	34961338	Silent	SNP	C	TCGA-CV-6933-01A-11D-1912-08	29149827	34961338	120309222	135	35386											
COL4A5	1287	broad.mit.edu	37	chrX	107924156	107924156	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctggatcagctggccctGagggggaaccgggacttatt	8	9	14	10	1	1	1	1	1	0	0	1	4	1	4	3	5	3	1	3	5	3	3			TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:107924156G>T	uc004enz.1	+	45	4259	c.4057G>T	c.(4057-4059)GAG>TAG	p.E1353*	COL4A5_uc011mso.1_Nonsense_Mutation_p.E1350*|COL4A5_uc011msp.1_Nonsense_Mutation_p.E29*	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1347	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						AGCTGGCCCTGAGGGGGAACC	0.448									Alport_syndrome_with_Diffuse_Leiomyomatosis				51	25					1.86277e-20	1.0947e-19	1	0	T	107924156	T	T	107924156	4	4	192	1	0	0	0	0	0	1	0	0	3709	1291	45	2	4224	2	COL4A5	23	107924156	Nonsense_Mutation	SNP	G	TCGA-CV-6933-01A-11D-1912-08	72962818	107924156	47346404	136	35387											
NKAP	79576	broad.mit.edu	37	chrX	119077333	119077338	+	In_Frame_Del	DEL	CGCGAC	-	-																															cagagggccgctctctagaaCgcgaccgcgagcgtgagcgg																										TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:119077333_119077338delCGCGAC	uc004esh.2	-	1	398_403	c.231_236delGTCGCG	c.(229-237)CGGTCGCGT>CGT	p.77_79RSR>R		NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	77_79	Ser-rich.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						CTCTCTAGAACGCGACCGCGAGCGTG	0.66													---	---	---								-	119077338	-	-	119077333	7	5	192	1	0	1	0	1	0	0	0	0	10493	536	19	0	1047	0	NKAP	23	119077333	In_Frame_Del	DEL	CGCGAC	TCGA-CV-6933-01A-11D-1912-08	11153177	119077333	36193227	137	35388											
CT47B1	643311	broad.mit.edu	37	chrX	120008849	120008850	+	Nonsense_Mutation	DNP	TC	AG	AG																															tgcggcctcctctgggggttTctcatctgcggcctcctccg																										TCGA-CV-6933-01A-11D-1912-08	TCGA-CV-6933-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ef4b02e-4d34-4d58-aa2d-65a7f73982d5	dfa4a23b-1955-4187-a694-d6e89adb396b	g.chrX:120008849_120008850TC>AG	uc011muc.1	-	1	930_931	c.675_676GA>CT	c.(673-678)GAGAAA>GACTAA	p.225_226EK>D*		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	225_226											0						tctgGGGGTTTCTCATCTGCGG	0.559													6	136					0	0	0	0	AG	120008850	AG	AG	120008849	4	1	192	1	0	0	0	0	0	1	0	0	4006	1792	62	5	231	5	CT47B1	23	120008849	Nonsense_Mutation	DNP	TC	TCGA-CV-6933-01A-11D-1912-08	931516	120008849	35261711	138	35389											
PRAMEF10	343071	broad.mit.edu	37	chr1	12954474	12954474	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttttttatataaagcatcTgggggtagtacaggcagagg	11	13	12	5	0	2	1	0	0	2	1	2	1	2	1	0	4	2	4	0	4	6	7			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:12954474T>A	uc001auo.2	-	3	882	c.809A>T	c.(808-810)CAG>CTG	p.Q270L		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	270											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATAAAGCATCTGGGGGTAGTA	0.473													41	165					0	0	0	0	A	12954474	A	A	12954474	3	1	193	1	0	0	0	0	1	0	0	0	12486	1580	55	5	623	5	PRAMEF10	1	12954474	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08		12954474	236296147	1	35390											
CTRC	11330	broad.mit.edu	37	chr1	15771229	15771229	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcgctgggggcgatggcGtcatctcagcctgcaatgtg	5	10	16	10	3	2	0	2	0	1	0	3	1	2	0	1	3	3	2	1	3	1	0			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:15771229G>A	uc001awi.1	+	6	645	c.622G>A	c.(622-624)GTC>ATC	p.V208I	CTRC_uc001awj.1_Intron	NM_007272	NP_009203	Q99895	CTRC_HUMAN	chymotrypsin C preproprotein	208	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCGATGGCGTCATCTCAGC	0.612													9	55					0	0	0	0	A	15771229	A	A	15771229	3	1	193	1	0	0	0	0	1	0	0	0	4044	1145	40	1	644	1	CTRC	1	15771229	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	2816755	15771229	233479392	2	35391											
SLC9A1	6548	broad.mit.edu	37	chr1	27427055	27427055	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagctcttcattcaccaggtCcacagactcgggtgactgcg	8	9	10	14	2	3	2	2	1	1	1	5	2	4	2	2	2	2	1	2	2	0	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:27427055C>T	uc001bnm.2	-	12	2817	c.2191G>A	c.(2191-2193)GAC>AAC	p.D731N	SLC9A1_uc001bnl.2_Missense_Mutation_p.D235N|SLC9A1_uc010ofk.1_Missense_Mutation_p.D392N	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	731	Cytoplasmic (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	TTCACCAGGTCCACAGACTCG	0.602													61	246					0	0	0	0	T	27427055	T	T	27427055	3	4	193	1	0	0	0	0	1	0	0	0	14773	855	30	2	260	2	SLC9A1	1	27427055	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	11655826	27427055	221823566	3	35392											
WASF2	10163	broad.mit.edu	37	chr1	27736225	27736225	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtcgctacgggcatcgcTcacggcaggcaaggaggact	9	5	15	12	4	1	0	1	0	0	0	3	2	1	2	0	6	1	5	0	6	2	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:27736225T>A	uc001bof.1	-	8	1516	c.1300A>T	c.(1300-1302)AGC>TGC	p.S434C	WASF2_uc010ofl.1_Intron	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	434					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		CGGGCATCGCTCACGGCAGGC	0.577													12	72					0	0	0	0	A	27736225	A	A	27736225	3	1	193	1	0	0	0	0	1	0	0	0	17321	1551	54	5	204	5	WASF2	1	27736225	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	309170	27736225	221514396	4	35393											
PHACTR4	65979	broad.mit.edu	37	chr1	28800237	28800237	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gagcacgtgttctatgggctCggaactactaccaatgatct	10	11	10	10	2	2	1	0	1	2	0	3	3	2	2	1	2	4	3	1	2	5	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:28800237C>G	uc001bpw.2	+	7	1277	c.995C>G	c.(994-996)TCG>TGG	p.S332W	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.S316W|PHACTR4_uc001bpy.2_Missense_Mutation_p.S342W	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	332	Pro-rich.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TCTATGGGCTCGGAACTACTA	0.537													35	122					0	0	0	0	G	28800237	G	G	28800237	3	3	193	1	0	0	0	0	1	0	0	0	11867	893	31	3	1067	3	PHACTR4	1	28800237	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	1064012	28800237	220450384	5	35394											
AK2	204	broad.mit.edu	37	chr1	33502361	33502361	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccctttaccggccccgggAggccccagcagcacggcccg	5	4	13	19	4	0	0	0	0	0	0	1	1	1	1	7	4	3	2	7	4	1	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:33502361A>G	uc001bwp.1	-	1	111	c.69T>C	c.(67-69)CCT>CCC	p.P23P	AK2_uc001bwo.1_Silent_p.P23P|AK2_uc010ohq.1_Silent_p.P23P|AK2_uc009vud.1_Silent_p.P23P|AK2_uc010ohr.1_5'UTR|AK2_uc001bwq.1_5'UTR	NM_001625	NP_001616	P54819	KAD2_HUMAN	adenylate kinase 2 isoform a	23	ATP (By similarity).				nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CGGCCCCGGGAGGCCCCAGCA	0.667													2	10					0	0	0	0	G	33502361	G	G	33502361	2	3	193	1	0	0	0	0	0	0	0	1	440	291	11	5		5	AK2	1	33502361	Silent	SNP	A	TCGA-CV-6934-01A-11D-1912-08	4702124	33502361	215748260	6	35395											
ZMYM4	9202	broad.mit.edu	37	chr1	35853113	35853113	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaatataagaaaataaataAtgtaatggcaatgtgtgaat	20	12	8	1	0	0	3	0	2	0	1	0	3	0	3	0	1	0	2	0	1	11	5			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:35853113A>T	uc001byt.2	+	13	2251	c.2171A>T	c.(2170-2172)AAT>ATT	p.N724I	ZMYM4_uc009vuu.2_Missense_Mutation_p.N692I|ZMYM4_uc001byu.2_Missense_Mutation_p.N400I|ZMYM4_uc009vuv.2_Missense_Mutation_p.N463I	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	724	MYM-type 7.				multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAAATAAATAATGTAATGGCA	0.318													12	34					0	0	0	0	T	35853113	T	T	35853113	3	4	193	1	0	0	0	0	1	0	0	0	17769	101	4	5	2221	5	ZMYM4	1	35853113	Missense_Mutation	SNP	A	TCGA-CV-6934-01A-11D-1912-08	2350752	35853113	213397508	7	35396											
CHI3L2	1117	broad.mit.edu	37	chr1	111778261	111778261	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgtttctttgtttttcctagGagttagcagaagcctttcag	7	17	9	8	1	2	1	1	0	1	1	3	2	3	2	2	1	2	4	2	1	3	7			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:111778261G>T	uc001eam.2	+	6	552	c.481G>T	c.(481-483)GAG>TAG	p.E161*	CHI3L2_uc001ean.2_Nonsense_Mutation_p.E151*|CHI3L2_uc001eao.2_Nonsense_Mutation_p.E82*|CHI3L2_uc009wga.2_Nonsense_Mutation_p.E82*	NM_004000	NP_003991	Q15782	CH3L2_HUMAN	chitinase 3-like 2 isoform a	161					chitin catabolic process	extracellular space	cation binding|chitinase activity			central_nervous_system(1)	1		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		TTTTTCCTAGGAGTTAGCAGA	0.448													28	79					2.44723e-14	2.98117e-14	1	0	T	111778261	T	T	111778261	4	4	193	1	0	0	0	0	0	1	0	0	3356	1188	41	2	503	2	CHI3L2	1	111778261	Nonsense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	75925148	111778261	137472360	8	35397											
TADA1	117143	broad.mit.edu	37	chr1	166826916	166826916	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgatgatcctttcaatgttaAgagcatagacagtatgtgta	13	14	9	5	0	1	4	1	2	0	2	2	4	2	4	1	0	1	4	1	0	5	5			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:166826916A>G	uc001gdw.2	-	8	1080	c.896T>C	c.(895-897)CTT>CCT	p.L299P	TADA1_uc001gdv.2_Missense_Mutation_p.L157P	NM_053053	NP_444281	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1-like	299					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(1)	1						TTCAATGTTAAGAGCATAGAC	0.438													26	63					0	0	0	0	G	166826916	G	G	166826916	3	3	193	1	0	0	0	0	1	0	0	0	15575	72	3	5	115	5	TADA1	1	166826916	Missense_Mutation	SNP	A	TCGA-CV-6934-01A-11D-1912-08	55048655	166826916	82423705	9	35398											
LAMC1	3915	broad.mit.edu	37	chr1	183095288	183095288	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gccttgggctccaccaatggGcagtgtgacatccgcaccgg	7	7	13	14	2	0	1	0	1	0	0	2	1	2	1	5	3	0	3	5	3	1	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:183095288G>A	uc001gpy.3	+	16	3092	c.2835G>A	c.(2833-2835)GGG>GGA	p.G945G		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	945	Laminin EGF-like 10.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCACCAATGGGCAGTGTGACA	0.507													14	41					0	0	0	0	A	183095288	A	A	183095288	2	1	193	1	0	0	0	0	0	0	0	1	8654	1190	42	4		4	LAMC1	1	183095288	Silent	SNP	G	TCGA-CV-6934-01A-11D-1912-08	16268372	183095288	66155333	10	35399											
KCNT2	343450	broad.mit.edu	37	chr1	196197396	196197396	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaatcttgaccagtgacattGcagatgctgtttcttcgact	9	14	9	9	1	2	3	0	2	2	1	3	5	2	3	1	0	2	3	1	0	1	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:196197396G>T	uc001gtd.1	-	28	3426	c.3366C>A	c.(3364-3366)TGC>TGA	p.C1122*	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Nonsense_Mutation_p.C1055*|KCNT2_uc001gtf.1_Nonsense_Mutation_p.C1098*|KCNT2_uc001gtg.1_RNA	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1122	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CAGTGACATTGCAGATGCTGT	0.363													5	23					0.000602214	0.000661449	1	0	T	196197396	T	T	196197396	4	4	193	1	0	0	0	0	0	1	0	0	8131	1311	46	4	45	4	KCNT2	1	196197396	Nonsense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	13102108	196197396	53053225	11	35400											
CNTN2	6900	broad.mit.edu	37	chr1	205034950	205034950	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatctgaccatcctgaacGcccagctgcgccatgggggg	7	6	15	13	2	1	2	0	2	1	0	2	3	2	3	4	4	3	1	4	4	1	0			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:205034950G>A	uc001hbr.2	+	14	1998	c.1729G>A	c.(1729-1731)GCC>ACC	p.A577T	CNTN2_uc001hbq.1_Missense_Mutation_p.A468T|CNTN2_uc001hbs.2_Missense_Mutation_p.A365T	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	577	Ig-like C2-type 6.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CATCCTGAACGCCCAGCTGCG	0.642													15	53					0	0	0	0	A	205034950	A	A	205034950	3	1	193	1	0	0	0	0	1	0	0	0	3656	1087	38	1	1779	1	CNTN2	1	205034950	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	8837554	205034950	44215671	12	35401											
ACBD3	64746	broad.mit.edu	37	chr1	226334387	226334387	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agttgtcaaacttgaggagaTagactcctctccctggatat	11	12	9	9	0	2	3	1	1	1	2	4	5	3	4	2	2	1	1	2	2	3	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:226334387T>C	uc001hpy.2	-	8	1558	c.1511A>G	c.(1510-1512)TAT>TGT	p.Y504C		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	504	GOLD.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		CTTGAGGAGATAGACTCCTCT	0.453													18	81					0	0	0	0	C	226334387	C	C	226334387	3	2	193	1	0	0	0	0	1	0	0	0	123	1406	49	5	79	5	ACBD3	1	226334387	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	21299437	226334387	22916234	13	35402											
OBSCN	84033	broad.mit.edu	37	chr1	228431117	228431117	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgccggggactacagctgcGaggccaggggccagagggtc	8	4	18	11	2	0	1	0	0	0	1	1	3	0	2	3	6	4	1	3	6	1	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:228431117G>A	uc009xez.1	+	10	3207	c.3163G>A	c.(3163-3165)GAG>AAG	p.E1055K	OBSCN_uc001hsn.2_Missense_Mutation_p.E1055K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1055	Ig-like 10.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTACAGCTGCGAGGCCAGGGG	0.552													8	35					0	0	0	0	A	228431117	A	A	228431117	3	1	193	1	0	0	0	0	1	0	0	0	10866	1059	37	1	3197	1	OBSCN	1	228431117	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	2096730	228431117	20819504	14	35403											
ZNF512	84450	broad.mit.edu	37	chr2	27822849	27822849	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgtcagggaggaagcaacGgcctaaaactcagcccaatc	14	6	10	11	1	2	0	2	0	0	0	3	2	2	2	2	3	4	1	2	3	6	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:27822849G>A	uc002rla.2	+	5	473	c.386G>A	c.(385-387)CGG>CAG	p.R129Q	ZNF512_uc010ylv.1_Missense_Mutation_p.R50Q|ZNF512_uc010ylw.1_Intron|ZNF512_uc002rlb.2_Missense_Mutation_p.R50Q|ZNF512_uc010ylx.1_Missense_Mutation_p.R50Q|ZNF512_uc002rlc.2_Missense_Mutation_p.R50Q|ZNF512_uc010yly.1_RNA|ZNF512_uc010ylz.1_Intron	NM_032434	NP_115810	Q96ME7	ZN512_HUMAN	zinc finger protein 512	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					AGGAAGCAACGGCCTAAAACT	0.473													6	18					0	0	0	0	A	27822849	A	A	27822849	3	1	193	1	0	0	0	0	1	0	0	0	18023	1116	39	1	404	1	ZNF512	2	27822849	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08		27822849	215376524	15	35404											
NEB	4703	broad.mit.edu	37	chr2	152375496	152375496	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacagaactggcaagttggcTtgtattcaggacatgattca	12	12	10	7	0	2	2	2	1	0	1	2	3	2	3	0	3	2	4	0	3	4	6			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:152375496T>G	uc010fnx.2	-	127	17766	c.17575A>C	c.(17575-17577)AGC>CGC	p.S5859R	NEB_uc002txr.2_Missense_Mutation_p.S2282R|NEB_uc002txt.3_Missense_Mutation_p.S364R	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5859	Nebulin 160.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCAAGTTGGCTTGTATTCAGG	0.423													5	32					0	0	0	0	G	152375496	G	G	152375496	3	3	193	1	0	0	0	0	1	0	0	0	10356	1609	56	5	3011	5	NEB	2	152375496	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	124552647	152375496	90823877	16	35405											
XIRP2	129446	broad.mit.edu	37	chr2	168106357	168106357	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagggaaacttccaggaagtGaagaaaaaaatcagggacca	19	4	12	6	0	1	2	1	1	0	1	2	6	2	5	2	3	1	0	2	3	6	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:168106357G>A	uc002udx.2	+	8	8473	c.8455G>A	c.(8455-8457)GAA>AAA	p.E2819K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E2644K|XIRP2_uc010fpq.2_Missense_Mutation_p.E2597K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.E165K	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2644					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCCAGGAAGTGAAGAAAAAAA	0.393													8	32					0	0	0	0	A	168106357	A	A	168106357	3	1	193	1	0	0	0	0	1	0	0	0	17498	1291	45	2	8485	2	XIRP2	2	168106357	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	15730861	168106357	75093016	17	35406											
TLK1	9874	broad.mit.edu	37	chr2	171906348	171906348	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caagattctgaaatgcaaaaCcatctgtccattgttcagta	14	12	6	9	0	3	2	1	1	2	1	4	2	4	2	2	0	2	3	2	0	5	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:171906348C>G	uc002ugn.2	-	10	1428	c.956G>C	c.(955-957)GGT>GCT	p.G319A	TLK1_uc002ugo.2_Missense_Mutation_p.G340A|TLK1_uc002ugp.2_Missense_Mutation_p.G271A|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Missense_Mutation_p.G223A|TLK1_uc002ugr.1_Missense_Mutation_p.G102A	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	319					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						AAATGCAAAACCATCTGTCCA	0.348													12	49					0	0	0	0	G	171906348	G	G	171906348	3	3	193	1	0	0	0	0	1	0	0	0	16009	507	18	4	1392	4	TLK1	2	171906348	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	3799991	171906348	71293025	18	35407											
TTN	7273	broad.mit.edu	37	chr2	179483053	179483053	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagtaaactcacaactctctGcacggtctgtggccagaacc	11	8	8	14	1	3	1	1	0	2	1	4	1	3	1	2	2	4	2	2	2	4	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:179483053G>T	uc010zfg.1	-	201	39652	c.39428C>A	c.(39427-39429)GCA>GAA	p.A13143E	TTN_uc010zfh.1_Missense_Mutation_p.A6838E|TTN_uc010zfi.1_Missense_Mutation_p.A6771E|TTN_uc010zfj.1_Missense_Mutation_p.A6646E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14070							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAACTCTCTGCACGGTCTGT	0.463													15	87					6.31663e-08	7.36024e-08	1	0	T	179483053	T	T	179483053	3	4	193	1	0	0	0	0	1	0	0	0	16803	1319	46	4	61005	4	TTN	2	179483053	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	7576705	179483053	63716320	19	35408											
TTN	7273	broad.mit.edu	37	chr2	179549086	179549086	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggaggcgcctcttttttaGttacagcaacaagaactttt	10	15	8	8	1	1	1	0	0	1	1	1	2	1	2	1	2	4	2	1	2	5	7			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:179549086G>A	uc010zfg.1	-	129	29185	c.28961C>T	c.(28960-28962)ACT>ATT	p.T9654I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T6315I|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10581							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTTTTTTAGTTACAGCAAC	0.398													4	36					0	0	0	0	A	179549086	A	A	179549086	3	1	193	1	0	0	0	0	1	0	0	0	16803	1029	36	4	71760	4	TTN	2	179549086	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	66033	179549086	63650287	20	35409											
SOX2	6657	broad.mit.edu	37	chr3	181430873	181430873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctcttggctccatgggttCggtggtcaagtccgaggcca	5	10	15	11	2	2	0	1	0	1	0	5	1	4	0	3	6	0	3	3	6	1	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr3:181430873C>T	uc003fkx.2	+	1	1152	c.725C>T	c.(724-726)TCG>TTG	p.S242L	SOX2OT_uc003fkv.2_Intron|SOX2OT_uc003fkw.3_Intron	NM_003106	NP_003097	P48431	SOX2_HUMAN	sex-determining region Y-box 2	242					cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			TCCATGGGTTCGGTGGTCAAG	0.652			A		NSCLC|oesophageal squamous carcinoma		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						16	95					0	0	0	0	T	181430873	T	T	181430873	3	4	193	1	0	0	0	0	1	0	0	0	15013	893	31	1	727	1	SOX2	3	181430873	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08		181430873	16591557	21	35410											
ABCG2	9429	broad.mit.edu	37	chr4	89052340	89052340	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgtaagttttctctcaccGtcagagtgcccatcacaaca	11	11	6	13	1	4	1	3	0	1	1	5	1	4	1	2	0	2	2	2	0	2	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr4:89052340G>T	uc003hrg.2	-	5	897	c.404C>A	c.(403-405)ACG>AAG	p.T135K	ABCG2_uc003hrh.2_Missense_Mutation_p.T135K|ABCG2_uc003hrf.2_Missense_Mutation_p.T5K	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	135	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	TTCTCTCACCGTCAGAGTGCC	0.378													10	88					0.00621372	0.00650498	1	0	T	89052340	T	T	89052340	3	4	193	1	0	0	0	0	1	0	0	0	69	1145	40	3	1611	3	ABCG2	4	89052340	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08		89052340	102101936	22	35411											
METTL14	57721	broad.mit.edu	37	chr4	119621732	119621732	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agttagaaattgatgagattGcagcacctcgatcatttatt	13	14	8	6	1	1	3	1	2	0	2	2	5	1	3	1	0	2	3	1	0	3	6			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr4:119621732G>C	uc003icf.2	+	8	789	c.673G>C	c.(673-675)GCA>CCA	p.A225P	METTL14_uc003icg.2_Missense_Mutation_p.A187P	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	225						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						TGATGAGATTGCAGCACCTCG	0.348													8	51					0	0	0	0	C	119621732	C	C	119621732	3	2	193	1	0	0	0	0	1	0	0	0	9551	1319	46	4	703	4	METTL14	4	119621732	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	30569392	119621732	71532544	23	35412											
SEC24D	9871	broad.mit.edu	37	chr4	119727067	119727067	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctggtgttggtggcataaaCttgtcctcctctgctggctc	4	15	11	11	0	2	0	0	0	2	0	5	0	4	0	2	4	2	4	2	4	2	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr4:119727067C>G	uc003ici.3	-	7	1116	c.844G>C	c.(844-846)GTT>CTT	p.V282L	SEC24D_uc003icj.3_Missense_Mutation_p.V283L|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA|SEC24D_uc011cgg.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	282	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						GTGGCATAAACTTGTCCTCCT	0.428													19	52					0	0	0	0	G	119727067	G	G	119727067	3	3	193	1	0	0	0	0	1	0	0	0	14062	565	20	4	2322	4	SEC24D	4	119727067	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	105335	119727067	71427209	24	35413											
CTNND2	1501	broad.mit.edu	37	chr5	11082866	11082866	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcagcgcagtggccaccgcGcacaccacacggtcattgtc	8	5	11	17	5	1	0	1	0	0	0	2	0	1	0	3	2	1	3	3	2	0	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr5:11082866G>A	uc003jfa.1	-	16	2875	c.2730C>T	c.(2728-2730)TGC>TGT	p.C910C	CTNND2_uc010itt.2_Silent_p.C819C|CTNND2_uc011cmy.1_Silent_p.C573C|CTNND2_uc011cmz.1_Silent_p.C477C|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.C502C	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	910	ARM 8.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGGCCACCGCGCACACCACAC	0.527													20	77					0	0	0	0	A	11082866	A	A	11082866	2	1	193	1	0	0	0	0	0	0	0	1	4037	1079	38	1		1	CTNND2	5	11082866	Silent	SNP	G	TCGA-CV-6934-01A-11D-1912-08		11082866	169832394	25	35414											
CRHBP	1393	broad.mit.edu	37	chr5	76251503	76251503	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgatggttggattctcaaggGggagaagttccccagttccc	8	11	13	9	0	1	2	1	1	1	1	4	4	3	3	3	4	0	3	3	4	2	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr5:76251503G>A	uc003ker.2	+	4	639	c.359G>A	c.(358-360)GGG>GAG	p.G120E	CRHBP_uc010izx.2_Missense_Mutation_p.G120E	NM_001882	NP_001873	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	120					female pregnancy|learning or memory|signal transduction	soluble fraction					0		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		ATTCTCAAGGGGGAGAAGTTC	0.458													14	52					0	0	0	0	A	76251503	A	A	76251503	3	1	193	1	0	0	0	0	1	0	0	0	3885	1232	43	4	373	4	CRHBP	5	76251503	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	65168637	76251503	104663757	26	35415											
HMMR	3161	broad.mit.edu	37	chr5	162900509	162900509	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagaatattgttatattaTctaaacaagtagaagatcta	18	13	7	3	0	2	3	0	0	2	3	2	4	2	3	0	1	1	2	0	1	11	8			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr5:162900509T>G	uc003lzf.2	+	9	1029	c.847T>G	c.(847-849)TCT>GCT	p.S283A	HMMR_uc003lzh.2_Missense_Mutation_p.S284A|HMMR_uc003lzg.2_Missense_Mutation_p.S268A|HMMR_uc011dem.1_Missense_Mutation_p.S197A	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	283						cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		TGTTATATTATCTAAACAAGT	0.289													5	45					0	0	0	0	G	162900509	G	G	162900509	3	3	193	1	0	0	0	0	1	0	0	0	7281	1435	50	5	884	5	HMMR	5	162900509	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	86649006	162900509	18014751	27	35416											
MAK	4117	broad.mit.edu	37	chr6	10830857	10830857	+	Frame_Shift_Del	DEL	G	-	-																															atacgtgccgtcccccaactGtctcatggttgtgtatcggt																										TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:10830857delG	uc003mzl.2	-	1	254	c.25delC	c.(25-27)CAGfs	p.Q9fs	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_Intron|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Frame_Shift_Del_p.Q9fs|MAK_uc010jov.1_RNA	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	9	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				TCCCCCAACTGTCTCATGGTT	0.438													---	---	---								-	10830857	-	-	10830857	7	5	193	1	0	1	0	1	0	0	0	0	9250	1386	48	0	1898	0	MAK	6	10830857	Frame_Shift_Del	DEL	G	TCGA-CV-6934-01A-11D-1912-08		10830857	160284210	28	35417											
PRL	5617	broad.mit.edu	37	chr6	22290542	22290542	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatacagaggctcattccagGatcgcaatatgctgactatc	12	10	9	10	1	1	2	1	1	0	1	4	4	2	3	1	2	2	3	1	2	4	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:22290542G>T	uc003ndp.2	-	4	872	c.353C>A	c.(352-354)TCC>TAC	p.S118Y	PRL_uc003ndo.2_Missense_Mutation_p.S119Y|PRL_uc003ndq.2_Missense_Mutation_p.S118Y	NM_000948	NP_000939	P01236	PRL_HUMAN	prolactin precursor	118				S -> P (in Ref. 6; AAB70858).	cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding				0	Ovarian(93;0.163)					CTCATTCCAGGATCGCAATAT	0.428													4	48					0.000602214	0.000661449	1	0	T	22290542	T	T	22290542	3	4	193	1	0	0	0	0	1	0	0	0	12590	1174	41	2	338	2	PRL	6	22290542	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	11459685	22290542	148824525	29	35418											
HIST1H3F	8968	broad.mit.edu	37	chr6	26250638	26250638	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taccagacgctggaatggtaGcttgcgaatcagtagctcag	11	9	12	9	2	2	1	2	0	0	1	2	3	2	2	1	2	4	5	1	2	5	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:26250638G>A	uc003nhg.1	-	1	198	c.196C>T	c.(196-198)CTA>TTA	p.L66L	HIST1H2BH_uc003nhh.2_5'Flank	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	66					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						TGGAATGGTAGCTTGCGAATC	0.612											OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	117					0	0	0	0	A	26250638	A	A	26250638	2	1	193	1	0	0	0	0	0	0	0	1	7199	962	34	4		4	HIST1H3F	6	26250638	Silent	SNP	G	TCGA-CV-6934-01A-11D-1912-08	3960096	26250638	144864429	30	35419											
ZNF192	7745	broad.mit.edu	37	chr6	28116421	28116421	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgggccctttgccatcagtGgctgaggccagatttgaaca	9	9	12	11	1	1	3	1	2	0	1	1	3	1	3	3	3	2	1	3	3	1	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:28116421G>T	uc003nkn.1	+	2	420	c.236G>T	c.(235-237)TGG>TTG	p.W79L	ZNF192_uc010jqx.1_Missense_Mutation_p.W79L|ZNF192_uc010jqy.1_5'UTR|ZNF192_uc011dkz.1_5'UTR	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	79	SCAN box.				viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGCCATCAGTGGCTGAGGCCA	0.562													13	65					4.3838e-07	5.06405e-07	1	0	T	28116421	T	T	28116421	3	4	193	1	0	0	0	0	1	0	0	0	17823	1357	47	4	238	4	ZNF192	6	28116421	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	1865783	28116421	142998646	31	35420											
MAS1L	116511	broad.mit.edu	37	chr6	29455526	29455526	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcattcgtctcattttgaaGaaagacgccacagagctgag	12	11	9	9	2	2	5	2	2	1	3	4	5	2	5	1	0	1	1	1	0	2	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:29455526G>A	uc011dlq.1	-	1	154	c.154C>T	c.(154-156)CTT>TTT	p.L52F		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	52	Extracellular (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						TCATTTTGAAGAAAGACGCCA	0.507													20	56					0	0	0	0	A	29455526	A	A	29455526	3	1	193	1	0	0	0	0	1	0	0	0	9374	942	33	2	984	2	MAS1L	6	29455526	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	1339105	29455526	141659541	32	35421											
TNXB	7148	broad.mit.edu	37	chr6	32020730	32020730	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagggggctccggggcctcCgtgctgggttctgtgggggc	1	9	20	11	2	2	0	1	0	1	0	4	0	4	0	3	7	1	3	3	7	0	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:32020730C>T	uc003nzl.2	-	26	9028	c.8826G>A	c.(8824-8826)ACG>ACA	p.T2942T		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2989					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCGGGGCCTCCGTGCTGGGTT	0.657													14	100					0	0	0	0	T	32020730	T	T	32020730	2	4	193	1	0	0	0	0	0	0	0	1	16412	639	23	1		1	TNXB	6	32020730	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08	2565204	32020730	139094337	33	35422											
HLA-DMB	3109	broad.mit.edu	37	chr6	32906579	32906579	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtgctgtgagaggacattCgccaagctattcagcacccc	10	8	11	12	1	1	1	1	1	0	1	2	3	1	2	3	2	3	3	3	2	2	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:32906579C>T	uc003ocl.1	-	2	452	c.219G>A	c.(217-219)GCG>GCA	p.A73A	HLA-DMB_uc003ocj.1_Silent_p.A73A|HLA-DMB_uc003ock.1_5'Flank|HLA-DMB_uc010jud.1_5'Flank|HLA-DMB_uc010jue.1_5'Flank|HLA-DMB_uc010juf.1_5'Flank|HLA-DMB_uc011dql.1_Silent_p.A73A	NM_002118	NP_002109	P28068	DMB_HUMAN	major histocompatibility complex, class II, DM	73	Beta-1.|Lumenal (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						AGAGGACATTCGCCAAGCTAT	0.527													17	96					0	0	0	0	T	32906579	T	T	32906579	2	4	193	1	0	0	0	0	0	0	0	1	7238	871	31	1		1	HLA-DMB	6	32906579	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08	885849	32906579	138208488	34	35423											
ENPP4	22875	broad.mit.edu	37	chr6	46107985	46107985	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgacttagtccaaagactcaAgatgttagggctatgggaaa	14	10	11	6	0	1	3	1	1	0	2	2	4	2	4	1	2	0	2	1	2	6	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:46107985A>G	uc003oxy.2	+	2	924	c.665A>G	c.(664-666)AAG>AGG	p.K222R		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	222	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						CAAAGACTCAAGATGTTAGGG	0.408													17	68					0	0	0	0	G	46107985	G	G	46107985	3	3	193	1	0	0	0	0	1	0	0	0	5156	72	3	5	667	5	ENPP4	6	46107985	Missense_Mutation	SNP	A	TCGA-CV-6934-01A-11D-1912-08	13201406	46107985	125007082	35	35424											
RIPPLY2	134701	broad.mit.edu	37	chr6	84563844	84563844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggccctggaatgaccgcagCctcaggaaagctttaccaat	11	8	10	12	1	1	1	1	1	0	0	1	3	1	3	4	3	3	2	4	3	4	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:84563844C>T	uc003pke.2	+	3	354	c.203C>T	c.(202-204)GCC>GTC	p.A68V		NM_001009994	NP_001009994	Q5TAB7	RIPP2_HUMAN	ripply2 protein	68					somite rostral/caudal axis specification	nucleus					0						ATGACCGCAGCCTCAGGAAAG	0.587													10	56					0	0	0	0	T	84563844	T	T	84563844	3	4	193	1	0	0	0	0	1	0	0	0	13450	739	26	4	213	4	RIPPLY2	6	84563844	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	38455859	84563844	86551223	36	35425											
ARID1B	57492	broad.mit.edu	37	chr6	157525122	157525122	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcactgttgctactttcaatCtctcccaggtaagccagcat	9	12	7	13	0	2	0	1	0	1	0	4	0	3	0	2	1	4	5	2	1	3	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:157525122C>G	uc003qqn.2	+	19	5115	c.4963C>G	c.(4963-4965)CTC>GTC	p.L1655V	ARID1B_uc003qqo.2_Missense_Mutation_p.L1615V|ARID1B_uc003qqp.2_Missense_Mutation_p.L1602V	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1660					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TACTTTCAATCTCTCCCAGGT	0.428													75	258					0	0	0	0	G	157525122	G	G	157525122	3	3	193	1	0	0	0	0	1	0	0	0	914	913	32	2	5091	2	ARID1B	6	157525122	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	72961278	157525122	13589945	37	35426											
MLLT4	4301	broad.mit.edu	37	chr6	168281147	168281147	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgctgtggctgaagctttaGagaagtatggtctggaaaaa	12	12	13	4	0	1	2	0	1	1	1	1	4	1	3	0	3	2	4	0	3	6	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:168281147G>C	uc003qwd.2	+	6	986	c.844G>C	c.(844-846)GAG>CAG	p.E282Q	MLLT4_uc003qwb.1_Missense_Mutation_p.E282Q|MLLT4_uc003qwc.1_Missense_Mutation_p.E283Q|MLLT4_uc003qwf.2_5'UTR	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	283	Ras-associating 2.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TGAAGCTTTAGAGAAGTATGG	0.383			T	MLL	AL								16	157					0	0	0	0	C	168281147	C	C	168281147	3	2	193	1	0	0	0	0	1	0	0	0	9682	943	33	2	869	2	MLLT4	6	168281147	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	10756025	168281147	2833920	38	35427											
RBAK	57786	broad.mit.edu	37	chr7	5103363	5103363	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacctgatagagagaatccaAgaaaacgaagacaaacattc	20	5	8	8	1	0	5	0	1	0	4	2	8	1	5	2	0	2	0	2	0	7	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr7:5103363A>G	uc010kss.1	+	6	600	c.276A>G	c.(274-276)CAA>CAG	p.Q92Q	LOC389458_uc003snr.2_Silent_p.Q92Q|RBAK_uc003sns.1_Silent_p.Q92Q	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	92					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		AGAGAATCCAAGAAAACGAAG	0.353													4	20					0	0	0	0	G	5103363	G	G	5103363	2	3	193	1	0	0	0	0	0	0	0	1	13165	69	3	5		5	RBAK	7	5103363	Silent	SNP	A	TCGA-CV-6934-01A-11D-1912-08		5103363	154035300	39	35428											
SAMD9L	219285	broad.mit.edu	37	chr7	92762824	92762824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaatccttttctgctaaaaCggaatggatggcattttgta	12	14	8	7	1	1	0	0	0	1	0	2	2	2	2	1	3	2	3	1	3	5	6			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr7:92762824C>T	uc003umh.1	-	5	3677	c.2461G>A	c.(2461-2463)GTT>ATT	p.V821I	SAMD9L_uc003umj.1_Missense_Mutation_p.V821I|SAMD9L_uc003umi.1_Missense_Mutation_p.V821I|SAMD9L_uc010lfb.1_Missense_Mutation_p.V821I|SAMD9L_uc003umk.1_Missense_Mutation_p.V821I|SAMD9L_uc010lfc.1_Missense_Mutation_p.V821I|SAMD9L_uc010lfd.1_Missense_Mutation_p.V821I|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	821										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TCTGCTAAAACGGAATGGATG	0.383													20	52					0	0	0	0	T	92762824	T	T	92762824	3	4	193	1	0	0	0	0	1	0	0	0	13892	536	19	1	2297	1	SAMD9L	7	92762824	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	87659461	92762824	66375839	40	35429											
LMTK2	22853	broad.mit.edu	37	chr7	97821898	97821898	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctatcagataatcttatgcaCcaagataattttgatccatt	14	15	4	8	0	2	3	1	1	1	2	3	3	3	3	2	0	1	1	2	0	5	7			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr7:97821898C>T	uc003upd.1	+	11	2414	c.2121C>T	c.(2119-2121)CAC>CAT	p.H707H		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	707					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					ATCTTATGCACCAAGATAATT	0.363													14	75					0	0	0	0	T	97821898	T	T	97821898	2	4	193	1	0	0	0	0	0	0	0	1	8901	506	18	4		4	LMTK2	7	97821898	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08	5059074	97821898	61316765	41	35430											
LRGUK	136332	broad.mit.edu	37	chr7	133886291	133886291	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attagagaataccttggattGactgaggaacctgccaagag	14	9	11	7	0	0	4	0	2	0	2	0	7	0	6	3	2	3	0	3	2	5	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr7:133886291G>C	uc003vrm.1	+	15	1822	c.1806G>C	c.(1804-1806)TTG>TTC	p.L602F		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	602							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						ACCTTGGATTGACTGAGGAAC	0.388													7	48					0	0	0	0	C	133886291	C	C	133886291	3	2	193	1	0	0	0	0	1	0	0	0	8993	1281	45	2	1864	2	LRGUK	7	133886291	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	36064393	133886291	25252372	42	35431											
ERI1	90459	broad.mit.edu	37	chr8	8869134	8869134	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaagagagcaattttgctGacagttattatgactacatt	14	14	8	5	0	0	4	0	3	0	1	0	5	0	4	0	0	3	3	0	0	5	6			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:8869134G>T	uc011kwu.1	+	3	630	c.370G>T	c.(370-372)GAC>TAC	p.D124Y	ERI1_uc003wsk.2_Missense_Mutation_p.D124Y	NM_153332	NP_699163	Q8IV48	ERI1_HUMAN	three prime histone mRNA exonuclease 1	124					gene silencing by RNA|rRNA 3'-end processing	cytoplasm|histone pre-mRNA 3'end processing complex|nucleolus	3'-5' exonuclease activity|histone pre-mRNA stem-loop binding|metal ion binding|ribosome binding|rRNA binding				0					Adenosine monophosphate(DB00131)	CAATTTTGCTGACAGTTATTA	0.348													17	30					1.02788e-11	1.22979e-11	1	0	T	8869134	T	T	8869134	3	4	193	1	0	0	0	0	1	0	0	0	5251	1290	45	2	380	2	ERI1	8	8869134	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08		8869134	137494888	43	35432											
ZFHX4	79776	broad.mit.edu	37	chr8	77763207	77763207	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aagaatgaggagcagaaaccGactaaagaacccttggaagt	18	5	11	7	1	0	4	0	1	0	3	0	7	0	6	2	2	3	1	2	2	7	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:77763207G>C	uc003yav.2	+	10	4302	c.3915G>C	c.(3913-3915)CCG>CCC	p.P1305P	ZFHX4_uc003yau.1_Silent_p.P1350P|ZFHX4_uc003yaw.1_Silent_p.P1305P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1305						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGCAGAAACCGACTAAAGAAC	0.398										HNSCC(33;0.089)			8	32					0	0	0	0	C	77763207	C	C	77763207	2	2	193	1	0	0	0	0	0	0	0	1	17702	1045	37	3		3	ZFHX4	8	77763207	Silent	SNP	G	TCGA-CV-6934-01A-11D-1912-08	68894073	77763207	68600815	44	35433											
NBN	4683	broad.mit.edu	37	chr8	90949281	90949281	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcatcagcaagagactctTcttttgcatgttgattttgt	9	17	8	7	0	4	2	2	1	2	1	4	4	4	2	0	0	2	3	0	0	1	6			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:90949281T>C	uc003yej.1	-	15	2317	c.2207A>G	c.(2206-2208)GAA>GGA	p.E736G	NBN_uc003yei.1_Missense_Mutation_p.E654G|NBN_uc011lgb.1_Missense_Mutation_p.K729E	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	736	EEXXXDDL motif.			EE->AA: Decreases ATM binding.	cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AAGAGACTCTTCTTTTGCATG	0.299								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				6	30					0	0	0	0	C	90949281	C	C	90949281	3	2	193	1	0	0	0	0	1	0	0	0	10244	1783	62	5	65	5	NBN	8	90949281	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	13186074	90949281	55414741	45	35434											
INTS8	55656	broad.mit.edu	37	chr8	95839504	95839504	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttcaagtttgtctgttccaGtattgaatatgctactaaat	11	17	6	7	0	2	1	1	1	1	0	3	1	3	1	1	0	2	4	1	0	7	8			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:95839504G>A	uc003yhb.2	+	3	445	c.319G>A	c.(319-321)GTA>ATA	p.V107I	INTS8_uc003yha.1_Missense_Mutation_p.V107I|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_5'Flank	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	107					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					GTCTGTTCCAGTATTGAATAT	0.383													35	60					0	0	0	0	A	95839504	A	A	95839504	3	1	193	1	0	0	0	0	1	0	0	0	7823	1029	36	4	329	4	INTS8	8	95839504	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	4890223	95839504	50524518	46	35435											
TG	7038	broad.mit.edu	37	chr8	133925427	133925427	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaaggggaccactttggcaCctctcccaggacatggtttg	8	9	11	13	0	1	0	0	0	1	0	2	2	1	2	4	5	0	2	4	5	1	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:133925427C>A	uc003ytw.2	+	20	4336	c.4295C>A	c.(4294-4296)ACC>AAC	p.T1432N	TG_uc010mdw.2_Missense_Mutation_p.T191N	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1432					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CACTTTGGCACCTCTCCCAGG	0.557													15	57					2.23348e-06	2.55801e-06	1	0	A	133925427	A	A	133925427	3	1	193	1	0	0	0	0	1	0	0	0	15879	507	18	4	4373	4	TG	8	133925427	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	38085923	133925427	12438595	47	35436											
TIGD5	84948	broad.mit.edu	37	chr8	144680434	144680436	+	In_Frame_Del	DEL	GAG	-	-																															agaagatgcggctggccaacGaggaggagatcgaccgcgcc																										TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:144680434_144680436delGAG	uc003yyx.1	+	1	214_216	c.214_216delGAG	c.(214-216)GAGdel	p.E74del	EEF1D_uc011lki.1_5'Flank|EEF1D_uc011lkj.1_5'Flank|EEF1D_uc003yyr.2_5'Flank|EEF1D_uc003yyt.2_5'Flank|EEF1D_uc011lkk.1_5'Flank|EEF1D_uc003yys.2_5'Flank|EEF1D_uc003yyv.2_5'Flank|EEF1D_uc003yyu.2_5'Flank|EEF1D_uc011lkl.1_5'Flank	NM_032862	NP_116251	Q53EQ6	TIGD5_HUMAN	tigger transposable element derived 5	123					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GCTGGCCAACGAGGAGGAGATCG	0.704													---	---	---								-	144680436	-	-	144680434	7	5	193	1	0	1	0	1	0	0	0	0	15965	1059	37	0	363	0	TIGD5	8	144680434	In_Frame_Del	DEL	GAG	TCGA-CV-6934-01A-11D-1912-08	10755007	144680434	1683588	48	35437											
TMEM2	23670	broad.mit.edu	37	chr9	74364981	74364981	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctggagcatattttgaggaTattcctaaaatgattgcaag	13	14	9	5	0	1	2	0	2	1	0	2	4	2	4	1	2	2	2	1	2	5	7			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr9:74364981T>C	uc011lsa.1	-	2	849	c.309A>G	c.(307-309)ATA>ATG	p.I103M	TMEM2_uc010mos.2_Missense_Mutation_p.I103M|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	103	Helical; (Potential).					integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		ATTTTGAGGATATTCCTAAAA	0.294													6	29					0	0	0	0	C	74364981	C	C	74364981	3	2	193	1	0	0	0	0	1	0	0	0	16187	1396	49	5	3934	5	TMEM2	9	74364981	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08		74364981	66848450	49	35438											
SVEP1	79987	broad.mit.edu	37	chr9	113233781	113233781	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtctttgttgagagtccttTtcagtttatttgtgatagtt	6	21	10	4	0	2	2	1	2	1	1	3	3	3	2	1	1	0	3	1	1	2	9			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr9:113233781T>C	uc010mtz.2	-	16	3198	c.2861A>G	c.(2860-2862)AAA>AGA	p.K954R	SVEP1_uc010mua.1_Missense_Mutation_p.K954R	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	954					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GAGAGTCCTTTTCAGTTTATT	0.403													3	40					0	0	0	0	C	113233781	C	C	113233781	3	2	193	1	0	0	0	0	1	0	0	0	15486	1841	64	5	7986	5	SVEP1	9	113233781	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	38868800	113233781	27979650	50	35439											
GTF3C4	9329	broad.mit.edu	37	chr9	135554721	135554722	+	Frame_Shift_Ins	INS	-	T	T																															gaaagcagtggagtcacctaINStttttggcgttttaagcttt																										TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr9:135554721_135554722insT	uc010mzv.2	+	2	1973_1974	c.1715_1716insT	c.(1714-1716)TATfs	p.Y572fs	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	572					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GGAGTCACCTATTTTTGGCGTT	0.371													---	---	---								T	135554722	T	T	135554721	7	5	193	1	0	1	1	0	0	0	0	0	6914	449	16	0	1721	0	GTF3C4	9	135554721	Frame_Shift_Ins	INS	-	TCGA-CV-6934-01A-11D-1912-08	22320940	135554721	5658710	51	35440											
FRMD4A	55691	broad.mit.edu	37	chr10	13698719	13698719	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggaggaggtgctgtactgcGagccgctgtccgaggaggtg	6	7	20	8	3	0	0	0	0	0	0	1	5	1	3	2	5	4	3	2	5	1	1	rs143274194		TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:13698719G>A	uc001ims.2	-	22	3222	c.2870C>T	c.(2869-2871)TCG>TTG	p.S957L	FRMD4A_uc009xjf.1_Missense_Mutation_p.S957L	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	957	Ser-rich.					cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GCTGTACTGCGAGCCGCTGTC	0.667													4	37					0	0	0	0	A	13698719	A	A	13698719	3	1	193	1	0	0	0	0	1	0	0	0	6085	1059	37	1	261	1	FRMD4A	10	13698719	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08		13698719	121836028	52	35441											
CUBN	8029	broad.mit.edu	37	chr10	17126460	17126460	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcccaccacaacgcagatccGctaagaacagggaagagacg	15	3	10	13	3	0	3	0	0	0	3	2	5	2	4	3	1	2	2	3	1	4	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:17126460G>A	uc001ioo.2	-	17	2163	c.2111C>T	c.(2110-2112)TCG>TTG	p.S704L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	704					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACGCAGATCCGCTAAGAACAG	0.502													7	17					0	0	0	0	A	17126460	A	A	17126460	3	1	193	1	0	0	0	0	1	0	0	0	4068	1101	38	1	8964	1	CUBN	10	17126460	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	3427741	17126460	118408287	53	35442											
TFAM	7019	broad.mit.edu	37	chr10	60148561	60148561	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacaaacatttaaaaaggaaAgctatgacaaaaaaaaaagt	25	6	6	4	0	0	1	0	1	0	0	0	3	0	2	0	1	2	1	0	1	11	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:60148561A>T	uc001jkf.2	+	4	555	c.423A>T	c.(421-423)AAA>AAT	p.K141N	TFAM_uc001jkg.2_RNA|TFAM_uc001jkh.2_Missense_Mutation_p.K141N	NM_003201	NP_003192	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial precursor	141					DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TAAAAAGGAAAGCTATGACAA	0.264													19	69					0	0	0	0	T	60148561	T	T	60148561	3	4	193	1	0	0	0	0	1	0	0	0	15852	69	3	5	437	5	TFAM	10	60148561	Missense_Mutation	SNP	A	TCGA-CV-6934-01A-11D-1912-08	43022101	60148561	75386186	54	35443											
DUPD1	338599	broad.mit.edu	37	chr10	76803647	76803647	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaggtcgtcggcctccacgCcgtggtactggatgtccatg	5	9	14	13	4	0	0	0	0	0	0	4	1	2	1	4	4	1	2	4	4	1	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:76803647C>G	uc001jwq.1	-	2	329	c.329G>C	c.(328-330)GGC>GCC	p.G110A		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	110	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GGCCTCCACGCCGTGGTACTG	0.637													21	69					0	0	0	0	G	76803647	G	G	76803647	3	3	193	1	0	0	0	0	1	0	0	0	4826	739	26	4	341	4	DUPD1	10	76803647	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	16655086	76803647	58731100	55	35444											
RRP12	23223	broad.mit.edu	37	chr10	99132919	99132919	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttgaagaggatcggcagaaAgttcttggcaaagcgactca	13	8	13	7	2	2	3	1	1	1	2	3	5	2	4	0	3	1	4	0	3	3	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:99132919A>C	uc001knf.2	-	18	2204	c.2065T>G	c.(2065-2067)TTT>GTT	p.F689V	RRP12_uc009xvl.2_5'UTR|RRP12_uc009xvm.2_Missense_Mutation_p.F407V|RRP12_uc010qou.1_Missense_Mutation_p.F628V|RRP12_uc009xvn.2_Missense_Mutation_p.F589V	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	689						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		ATCGGCAGAAAGTTCTTGGCA	0.567													4	74					0	0	0	0	C	99132919	C	C	99132919	3	2	193	1	0	0	0	0	1	0	0	0	13751	72	3	5	1896	5	RRP12	10	99132919	Missense_Mutation	SNP	A	TCGA-CV-6934-01A-11D-1912-08	22329272	99132919	36401828	56	35445											
SORCS3	22986	broad.mit.edu	37	chr10	106960976	106960976	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcaggatcagtggtctcAgaaccctgtgtctgtgccaa	9	10	10	12	0	4	1	3	0	2	1	5	2	4	2	2	2	2	0	2	2	2	0			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:106960976A>C	uc001kyi.1	+	16	2453	c.2226A>C	c.(2224-2226)TCA>TCC	p.S742S	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	742	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAGTGGTCTCAGAACCCTGTG	0.522													15	85					0	0	0	0	C	106960976	C	C	106960976	2	2	193	1	0	0	0	0	0	0	0	1	14996	175	7	5		5	SORCS3	10	106960976	Silent	SNP	A	TCGA-CV-6934-01A-11D-1912-08	7828057	106960976	28573771	57	35446											
SWAP70	23075	broad.mit.edu	37	chr11	9759763	9759763	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtttttgattggctagaaaCtggaggaagcagcatctcgt	10	12	13	6	1	1	2	0	1	1	1	2	4	1	4	0	4	3	4	0	4	3	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:9759763C>T	uc001mhw.2	+	8	1183	c.1084C>T	c.(1084-1086)CTG>TTG	p.L362L	SWAP70_uc001mhv.2_Silent_p.L362L|SWAP70_uc001mhx.2_Silent_p.L304L	NM_015055	NP_055870	Q9UH65	SWP70_HUMAN	SWAP-70 protein	362	Potential.					cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			ovary(2)|central_nervous_system(1)	3				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		TGGCTAGAAACTGGAGGAAGC	0.448													11	29					0	0	0	0	T	9759763	T	T	9759763	2	4	193	1	0	0	0	0	0	0	0	1	15491	564	20	4		4	SWAP70	11	9759763	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08		9759763	125246753	58	35447											
ZDHHC5	25921	broad.mit.edu	37	chr11	57466839	57466839	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagccaaaaagcccaacCtggtgtctctgagacagaag	14	5	10	12	0	1	2	0	1	1	2	2	3	1	2	3	1	4	1	3	1	4	0			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:57466839C>T	uc001nkx.1	+	11	3187	c.1931C>T	c.(1930-1932)CCT>CTT	p.P644L	ZDHHC5_uc001nky.1_Missense_Mutation_p.P591L|ZDHHC5_uc001nkz.1_Missense_Mutation_p.P458L	NM_015457	NP_056272	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC domain containing 5	644						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)	1						AAAGCCCAACCTGGTGTCTCT	0.527													22	66					0	0	0	0	T	57466839	T	T	57466839	3	4	193	1	0	0	0	0	1	0	0	0	17685	681	24	4	1969	4	ZDHHC5	11	57466839	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	47707076	57466839	77539677	59	35448											
NUDT22	84304	broad.mit.edu	37	chr11	63994371	63994371	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacagctgctcctgcgcctgGgccttacttcctaccgagac	6	9	9	17	2	0	1	0	0	0	1	2	2	2	1	5	1	5	2	5	1	2	3	rs143695088	by1000genomes	TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:63994371G>T	uc001nyp.3	+	2	427	c.247G>T	c.(247-249)GGC>TGC	p.G83C	TRPT1_uc010rnc.1_5'Flank|TRPT1_uc010rnd.1_5'Flank|TRPT1_uc001nyn.2_5'Flank|TRPT1_uc001nyo.2_5'Flank|TRPT1_uc010rne.1_5'Flank|TRPT1_uc010rnf.1_5'Flank|NUDT22_uc009ypd.2_Missense_Mutation_p.G83C|NUDT22_uc009ype.2_Missense_Mutation_p.G83C|NUDT22_uc001nyq.3_Missense_Mutation_p.G83C|NUDT22_uc010rng.1_5'Flank	NM_032344	NP_115720	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety	83							hydrolase activity				0						CCTGCGCCTGGGCCTTACTTC	0.662													20	75					1.64113e-05	1.848e-05	1	0	T	63994371	T	T	63994371	3	4	193	1	0	0	0	0	1	0	0	0	10793	1232	43	4	249	4	NUDT22	11	63994371	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	6527532	63994371	71012145	60	35449											
ACTN3	89	broad.mit.edu	37	chr11	66330375	66330375	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgagagacagccgagactGacacgactgagcaagttgta	13	5	12	11	3	0	4	0	2	0	2	0	8	0	4	2	0	2	3	2	0	2	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:66330375G>C	uc001oio.1	+	21	2515	c.2497G>C	c.(2497-2499)GAC>CAC	p.D833H	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	833					focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						AGCCGAGACTGACACGACTGA	0.597													5	161					0	0	0	0	C	66330375	C	C	66330375	3	2	193	1	0	0	0	0	1	0	0	0	206	1290	45	2	2575	2	ACTN3	11	66330375	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	2336004	66330375	68676141	61	35450											
LRFN4	78999	broad.mit.edu	37	chr11	66626406	66626406	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctccgctcgcactgctgcCgagggtgaggggacgctgga	5	6	17	13	4	0	1	0	1	0	0	2	4	1	3	3	4	2	4	3	4	0	0			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:66626406C>T	uc001ojr.2	+	1	1531	c.1191C>T	c.(1189-1191)GCC>GCT	p.A397A	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojs.2_Silent_p.A397A	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	397	Extracellular (Potential).					integral to membrane					0						GCACTGCTGCCGAGGGTGAGG	0.731													5	57					0	0	0	0	T	66626406	T	T	66626406	2	4	193	1	0	0	0	0	0	0	0	1	8990	639	23	1		1	LRFN4	11	66626406	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08	296031	66626406	68380110	62	35451											
XRRA1	143570	broad.mit.edu	37	chr11	74562186	74562186	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcttaggctttactatctTccttcgaattaagtggattc	9	17	7	8	1	1	0	0	0	1	0	4	2	2	1	1	2	2	2	1	2	5	8			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:74562186T>G	uc009yub.2	-	14	1635	c.1303A>C	c.(1303-1305)AAG>CAG	p.K435Q	XRRA1_uc001ovm.2_RNA|XRRA1_uc001ovn.2_Missense_Mutation_p.K58Q|XRRA1_uc001ovo.2_Missense_Mutation_p.K43Q|XRRA1_uc001ovq.3_Missense_Mutation_p.K348Q|XRRA1_uc001ovp.3_Missense_Mutation_p.K160Q|XRRA1_uc001ovr.2_Missense_Mutation_p.K58Q|XRRA1_uc001ovs.1_Intron	NM_182969	NP_892014	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	435					response to X-ray	cytoplasm|nucleus				central_nervous_system(1)	1						TTTACTATCTTCCTTCGAATT	0.488													10	35					0	0	0	0	G	74562186	G	G	74562186	3	3	193	1	0	0	0	0	1	0	0	0	17529	1792	62	5	1099	5	XRRA1	11	74562186	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	7935780	74562186	60444330	63	35452											
PICALM	8301	broad.mit.edu	37	chr11	85712203	85712203	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attggaaagtgtagttgcccTaggataattgaacagagata	15	11	11	4	0	0	2	0	1	0	1	0	5	0	4	1	2	2	2	1	2	6	7			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:85712203T>A	uc001pbm.2	-	10	1180	c.894_splice	c.e10-1	p.R298_splice	PICALM_uc001pbl.2_Splice_Site_p.R298_splice|PICALM_uc001pbn.2_Splice_Site_p.R298_splice|PICALM_uc010rtl.1_Splice_Site_p.R247_splice|PICALM_uc010rtk.1_Splice_Site|PICALM_uc001pbo.1_Splice_Site	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly						clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				GTAGTTGCCCTAGGATAATTG	0.443			T	MLLT10|MLL	TALL|AML|								21	75					0	0	0	0	A	85712203	A	A	85712203	5	1	193	1	0	0	0	0	0	0	1	0	11935	1536	53	5	1138	5	PICALM	11	85712203	Splice_Site	SNP	T	TCGA-CV-6934-01A-11D-1912-08	11150017	85712203	49294313	64	35453											
PRSS23	11098	broad.mit.edu	37	chr11	86518800	86518800	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctgcataccgcctccctGtcgtcttgccccagtctacc	4	10	8	19	2	2	0	0	0	2	0	4	0	3	0	7	1	4	1	7	1	2	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:86518800G>A	uc001pcb.2	+	2	331	c.115G>A	c.(115-117)GTC>ATC	p.V39I	PRSS23_uc001pcc.1_Intron|PRSS23_uc010rts.1_Missense_Mutation_p.V39I	NM_007173	NP_009104	O95084	PRS23_HUMAN	protease, serine, 23 precursor	39					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCGCCTCCCTGTCGTCTTGCC	0.537													22	87					0	0	0	0	A	86518800	A	A	86518800	3	1	193	1	0	0	0	0	1	0	0	0	12682	1377	48	4	117	4	PRSS23	11	86518800	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	806597	86518800	48487716	65	35454											
MMP3	4314	broad.mit.edu	37	chr11	102709884	102709884	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgctagtaacttcatatgcGgcatccacgcctgaaggaag	11	10	10	10	2	1	1	1	1	0	0	2	2	2	2	2	2	3	3	2	2	5	5			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:102709884G>A	uc001phj.1	-	7	1091	c.1026C>T	c.(1024-1026)GCC>GCT	p.A342A		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	342	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.A342A(1)		lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CTTCATATGCGGCATCCACGC	0.378													21	59					0	0	0	0	A	102709884	A	A	102709884	2	1	193	1	0	0	0	0	0	0	0	1	9719	1103	39	1		1	MMP3	11	102709884	Silent	SNP	G	TCGA-CV-6934-01A-11D-1912-08	16191084	102709884	32296632	66	35455											
DYNC2H1	79659	broad.mit.edu	37	chr11	103022985	103022985	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ataaatttgagttaatgatgGaaagtcaccaacttatgatt	16	14	7	4	0	1	3	1	3	0	0	1	4	1	4	1	1	1	1	1	1	6	5			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:103022985G>T	uc001pho.2	+	21	3211	c.3067G>T	c.(3067-3069)GAA>TAA	p.E1023*	DYNC2H1_uc001phn.1_Nonsense_Mutation_p.E1023*|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1023	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GTTAATGATGGAAAGTCACCA	0.303													6	45					0.00198382	0.00212665	1	0	T	103022985	T	T	103022985	4	4	193	1	0	0	0	0	0	1	0	0	4868	1175	41	2	3149	2	DYNC2H1	11	103022985	Nonsense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	313101	103022985	31983531	67	35456											
NPAT	4863	broad.mit.edu	37	chr11	108044157	108044157	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attaagttttcattgttagcTtcacaaccaagtgaaacaaa	16	13	5	7	0	2	1	2	1	0	0	2	1	2	1	1	0	3	3	1	0	6	6			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:108044157T>A	uc001pjz.3	-	13	1656	c.1554A>T	c.(1552-1554)GAA>GAT	p.E518D	NPAT_uc001pka.2_Missense_Mutation_p.E313D	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	518					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		CATTGTTAGCTTCACAACCAA	0.348													19	51					0	0	0	0	A	108044157	A	A	108044157	3	1	193	1	0	0	0	0	1	0	0	0	10620	1606	56	5	2753	5	NPAT	11	108044157	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	5021172	108044157	26962359	68	35457											
VWA5A	4013	broad.mit.edu	37	chr11	123993667	123993667	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctttatcctttctgaacagGtcatttgatgggagatccat	9	15	9	8	0	2	3	1	2	1	1	4	4	4	3	2	2	1	1	2	2	2	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:123993667G>A	uc001pzu.2	+	8	970	c.761G>A	c.(760-762)GGT>GAT	p.G254D	VWA5A_uc001pzr.2_Missense_Mutation_p.G254D|VWA5A_uc001pzs.2_Missense_Mutation_p.G254D|VWA5A_uc010sae.1_Missense_Mutation_p.G270D|VWA5A_uc001pzt.2_Missense_Mutation_p.G254D	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	254										upper_aerodigestive_tract(1)|ovary(1)	2						TTCTGAACAGGTCATTTGATG	0.383													4	38					0	0	0	0	A	123993667	A	A	123993667	3	1	193	1	0	0	0	0	1	0	0	0	17310	1275	44	4	783	4	VWA5A	11	123993667	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	15949510	123993667	11012849	69	35458											
TMTC1	83857	broad.mit.edu	37	chr12	29659813	29659813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttctcgaacttcttgtaatCgtttttctaggcgatccaat	8	18	6	9	3	3	0	0	0	3	0	6	2	4	0	1	1	1	2	1	1	4	7			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr12:29659813C>T	uc001rjb.2	-	18	2765	c.2291G>A	c.(2290-2292)CGA>CAA	p.R764Q	TMTC1_uc001riz.2_Missense_Mutation_p.R521Q|TMTC1_uc001rja.2_Missense_Mutation_p.R608Q|TMTC1_uc001riy.2_Missense_Mutation_p.R217Q	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	872						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TTCTTGTAATCGTTTTTCTAG	0.448													15	143					0	0	0	0	T	29659813	T	T	29659813	3	4	193	1	0	0	0	0	1	0	0	0	16326	884	31	1	37	1	TMTC1	12	29659813	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08		29659813	104192082	70	35459											
SILV	6490	broad.mit.edu	37	chr12	56351770	56351771	+	Missense_Mutation	DNP	GG	AA	AA																															gctccgggatccccggcgatGgtagacagtcacttccatgg																										TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr12:56351770_56351771GG>AA	uc001sip.2	-	5	598_599	c.567_568CC>TT	c.(565-570)TACCAT>TATTAT	p.H190Y	SILV_uc001siq.2_Missense_Mutation_p.H190Y|SILV_uc010spx.1_Missense_Mutation_p.H104Y|SILV_uc001sir.2_Missense_Mutation_p.H190Y	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	190					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						CCCCGGCGATGGTAGACAGTCA	0.579													13	71					0	0	0	0	AA	56351771	AA	AA	56351770	3	1	193	1	0	0	0	0	1	0	0	0	14387	1348	47	4	1445	4	SILV	12	56351770	Missense_Mutation	DNP	GG	TCGA-CV-6934-01A-11D-1912-08	26691957	56351770	77500125	71	35460											
TRHDE	29953	broad.mit.edu	37	chr12	72863583	72863583	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtatgctgctatggagaactGgggactaagtatttttgtgg	9	14	14	4	0	0	1	0	0	0	1	0	3	0	2	0	4	3	4	0	4	5	6			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr12:72863583G>T	uc001sxa.2	+	4	1256	c.1226G>T	c.(1225-1227)TGG>TTG	p.W409L		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	409	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						ATGGAGAACTGGGGACTAAGT	0.378													15	67					4.7546e-09	5.58874e-09	1	0	T	72863583	T	T	72863583	3	4	193	1	0	0	0	0	1	0	0	0	16546	1357	47	4	1240	4	TRHDE	12	72863583	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	16511813	72863583	60988312	72	35461											
DNAH10	196385	broad.mit.edu	37	chr12	124268652	124268652	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatctgcagccagtgttcacCgagttattcaagttccacac	11	11	7	12	1	3	0	2	0	1	0	4	1	4	0	3	0	2	4	3	0	3	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr12:124268652C>T	uc001uft.3	+	8	1000	c.975C>T	c.(973-975)ACC>ACT	p.T325T		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	325	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAGTGTTCACCGAGTTATTCA	0.488													17	62					0	0	0	0	T	124268652	T	T	124268652	2	4	193	1	0	0	0	0	0	0	0	1	4620	639	23	1		1	DNAH10	12	124268652	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08	51405069	124268652	9583243	73	35462											
EP400	57634	broad.mit.edu	37	chr12	132534871	132534871	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgtcaatttcattgcagagtAaaaacaaccgtcctctccgt	12	11	6	12	3	3	1	2	0	1	1	5	1	4	1	3	0	3	2	3	0	5	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr12:132534871A>G	uc001ujn.2	+	39	7239	c.7204A>G	c.(7204-7206)AAA>GAA	p.K2402E	EP400_uc001ujl.2_Missense_Mutation_p.K2401E|EP400_uc001ujm.2_Missense_Mutation_p.K2321E	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2438					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ATTGCAGAGTAAAAACAACCG	0.507													16	71					0	0	0	0	G	132534871	G	G	132534871	3	3	193	1	0	0	0	0	1	0	0	0	5173	363	13	5	7355	5	EP400	12	132534871	Missense_Mutation	SNP	A	TCGA-CV-6934-01A-11D-1912-08	8266219	132534871	1317024	74	35463											
TGDS	23483	broad.mit.edu	37	chr13	95230316	95230316	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atttcaaaattggttccgatGttataaatttcacctggttt	11	18	6	6	1	2	0	2	0	0	0	3	1	3	0	2	2	0	3	2	2	5	7			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr13:95230316G>T	uc001vlw.2	-	9	889	c.768C>A	c.(766-768)AAC>AAA	p.N256K	TGDS_uc001vlx.2_RNA	NM_014305	NP_055120	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase	256					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					TGGTTCCGATGTTATAAATTT	0.358													7	34					0.00198382	0.00212665	1	0	T	95230316	T	T	95230316	3	4	193	1	0	0	0	0	1	0	0	0	15880	1368	48	4	300	4	TGDS	13	95230316	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08		95230316	19939562	75	35464											
FAM158A	51016	broad.mit.edu	37	chr14	24610485	24610485	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcaggcacatcttcacgtagGccagggccgagatctccacc	9	6	11	15	2	3	1	1	0	2	1	4	2	3	1	4	3	0	3	4	3	1	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr14:24610485G>C	uc001wmi.2	-	2	192	c.29C>G	c.(28-30)GCC>GGC	p.A10G		NM_016049	NP_057133	Q9Y3B6	F158A_HUMAN	hypothetical protein LOC51016	10				ALA -> GPG (in Ref. 1; AAD34107).							0						CTTCACGTAGGCCAGGGCCGA	0.657											OREG0022618	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	68					0	0	0	0	C	24610485	C	C	24610485	3	2	193	1	0	0	0	0	1	0	0	0	5495	1203	42	4	617	4	FAM158A	14	24610485	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08		24610485	82739055	76	35465											
AHNAK2	113146	broad.mit.edu	37	chr14	105409742	105409742	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaagggggctgaacgctgaGgtcagtggccttgaggtccc	7	7	18	9	1	1	3	1	3	0	0	2	4	2	4	2	6	1	2	2	6	2	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr14:105409742G>T	uc010axc.1	-	7	12166	c.12046C>A	c.(12046-12048)CTC>ATC	p.L4016I	AHNAK2_uc001ypx.2_Missense_Mutation_p.L3916I	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4016						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGAACGCTGAGGTCAGTGGCC	0.657													113	238					3.68091e-61	4.52516e-61	1	0	T	105409742	T	T	105409742	3	4	193	1	0	0	0	0	1	0	0	0	415	1000	35	4	5345	4	AHNAK2	14	105409742	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	80799257	105409742	1939798	77	35466											
OR4M2	390538	broad.mit.edu	37	chr15	22369305	22369305	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccatgtccacctgctatTcccacattaccattgtggtg	7	12	9	13	0	0	0	0	0	0	0	2	0	2	0	5	2	2	1	5	2	2	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr15:22369305T>G	uc010tzu.1	+	1	730	c.730T>G	c.(730-732)TCC>GCC	p.S244A	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CACCTGCTATTCCCACATTAC	0.448													19	136					0	0	0	0	G	22369305	G	G	22369305	3	3	193	1	0	0	0	0	1	0	0	0	11130	1783	62	5	732	5	OR4M2	15	22369305	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08		22369305	80162087	78	35467											
ZWILCH	55055	broad.mit.edu	37	chr15	66828269	66828269	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttatattttttcattccAggaatacttcattgctccat	9	19	4	9	0	2	0	2	0	0	0	4	1	4	1	2	1	3	2	2	1	4	9			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr15:66828269A>T	uc002aqb.2	+	15	1588	c.1342_splice	c.e15-2	p.E448_splice	ZWILCH_uc010bhu.1_Splice_Site_p.E334_splice|ZWILCH_uc002aqa.2_Splice_Site_p.E334_splice|ZWILCH_uc010bhv.2_Splice_Site_p.E334_splice	NM_017975	NP_060445	Q9H900	ZWILC_HUMAN	Zwilch						cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			ovary(1)	1						TTTTCATTCCAGGAATACTTC	0.343													4	50					0	0	0	0	T	66828269	T	T	66828269	5	4	193	1	0	0	0	0	0	0	1	0	18315	202	7	5	1398	5	ZWILCH	15	66828269	Splice_Site	SNP	A	TCGA-CV-6934-01A-11D-1912-08	44458964	66828269	35703123	79	35468											
MAP2K5	5607	broad.mit.edu	37	chr15	67995696	67995696	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgaaaggatttcaggggagCagtatggaattcattctgat	12	12	12	5	0	3	2	2	2	1	0	3	5	3	5	0	4	1	2	0	4	3	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr15:67995696C>A	uc002aqu.2	+	16	1647	c.994C>A	c.(994-996)CAG>AAG	p.Q332K	MAP2K5_uc002aqv.2_Missense_Mutation_p.Q332K|MAP2K5_uc002aqw.2_Missense_Mutation_p.Q172K|MAP2K5_uc002aqx.2_Missense_Mutation_p.Q142K	NM_145160	NP_660143	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	332	Protein kinase.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)	2						TTCAGGGGAGCAGTATGGAAT	0.423													22	91					1.10923e-09	1.31537e-09	1	0	A	67995696	A	A	67995696	3	1	193	1	0	0	0	0	1	0	0	0	9293	711	25	4	1056	4	MAP2K5	15	67995696	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	1167427	67995696	34535696	80	35469											
CACNA1H	8912	broad.mit.edu	37	chr16	1260937	1260937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatcctgggtgttctgcgcGtgctgcgtctgctgcggacc	3	11	15	12	4	2	1	0	0	2	1	3	2	3	2	2	2	5	3	2	2	0	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr16:1260937G>A	uc002cks.2	+	21	4437	c.4189G>A	c.(4189-4191)GTG>ATG	p.V1397M	CACNA1H_uc002ckt.2_Missense_Mutation_p.V1397M|CACNA1H_uc002cku.2_Missense_Mutation_p.V103M|CACNA1H_uc010brj.2_Missense_Mutation_p.V103M|CACNA1H_uc002ckv.2_Missense_Mutation_p.V103M	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1397	III.|Helical; Name=S4 of repeat III; (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TGTTCTGCGCGTGCTGCGTCT	0.682													39	141					0	0	0	0	A	1260937	A	A	1260937	3	1	193	1	0	0	0	0	1	0	0	0	2557	1145	40	1	4267	1	CACNA1H	16	1260937	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08		1260937	89093816	81	35470											
SEZ6L2	26470	broad.mit.edu	37	chr16	29884953	29884953	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcgaggctgtaccctggCaggcagcggtactggacgtg	6	7	15	13	3	0	0	0	0	0	0	1	2	0	1	2	5	3	5	2	5	2	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr16:29884953C>A	uc002duq.3	-	13	2442	c.2202G>T	c.(2200-2202)CTG>CTT	p.L734L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Silent_p.L664L|SEZ6L2_uc002dur.3_Silent_p.L664L|SEZ6L2_uc002dus.3_Silent_p.L620L|SEZ6L2_uc010vec.1_Silent_p.L734L|SEZ6L2_uc010ved.1_Silent_p.L690L	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	734	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TGTACCCTGGCAGGCAGCGGT	0.657													6	45					0.00116845	0.00127294	1	0	A	29884953	A	A	29884953	2	1	193	1	0	0	0	0	0	0	0	1	14209	697	25	4		4	SEZ6L2	16	29884953	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08	28624016	29884953	60469800	82	35471											
FTSJD1	55783	broad.mit.edu	37	chr16	71319701	71319705	+	Frame_Shift_Del	DEL	ATTAA	-	-																															tctggtaactgccactcattAttaagtggcttgccataaga																										TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr16:71319701_71319705delATTAA	uc010cga.2	-	3	525_529	c.119_123delTTAAT	c.(118-123)CTTAATfs	p.L40fs	FTSJD1_uc002ezy.3_Frame_Shift_Del_p.L40fs|FTSJD1_uc002ezz.3_Frame_Shift_Del_p.L40fs	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	40_41						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						GCCACTCATTATTAAGTGGCTTGCC	0.41													---	---	---								-	71319705	-	-	71319701	7	5	193	1	0	1	0	1	0	0	0	0	6124	446	16	0	2193	0	FTSJD1	16	71319701	Frame_Shift_Del	DEL	ATTAA	TCGA-CV-6934-01A-11D-1912-08	41434748	71319701	19035052	83	35472											
TP53	7157	broad.mit.edu	37	chr17	7578235	7578235	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagtgtttctgtcatccaaaTactccacacgcaaatttcct	12	13	4	12	1	2	0	1	0	1	0	5	0	5	0	3	0	1	2	3	0	4	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:7578235T>C	uc002gim.2	-	6	808	c.614A>G	c.(613-615)TAT>TGT	p.Y205C	TP53_uc002gig.1_Missense_Mutation_p.Y205C|TP53_uc002gih.2_Missense_Mutation_p.Y205C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y73C|TP53_uc010cng.1_Missense_Mutation_p.Y73C|TP53_uc002gii.1_Missense_Mutation_p.Y73C|TP53_uc010cnh.1_Missense_Mutation_p.Y205C|TP53_uc010cni.1_Missense_Mutation_p.Y205C|TP53_uc002gij.2_Missense_Mutation_p.Y205C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y112C|TP53_uc002gio.2_Missense_Mutation_p.Y73C|TP53_uc010vug.1_Missense_Mutation_p.Y166C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	205	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> C (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205C(55)|p.Y205D(13)|p.Y205S(11)|p.Y205F(8)|p.0?(7)|p.Y205H(5)|p.Y205*(4)|p.Y205N(2)|p.K164_P219del(1)|p.Y205fs*42(1)|p.Y112C(1)|p.Y205fs*43(1)|p.E204fs*39(1)|p.Y73C(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCATCCAAATACTCCACACG	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	26					0	0	0	0	C	7578235	C	C	7578235	3	2	193	1	0	0	0	0	1	0	0	0	16448	1406	49	5	680	5	TP53	17	7578235	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08		7578235	73616975	84	35473											
MBTD1	54799	broad.mit.edu	37	chr17	49270365	49270365	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattcctacacgaaatccgtGatttggaacatcctgacaca	13	10	6	12	2	0	2	0	2	0	0	3	4	3	3	3	1	2	0	3	1	3	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:49270365G>C	uc002itr.3	-	15	1812	c.1468C>G	c.(1468-1470)CAC>GAC	p.H490D	MBTD1_uc002itp.3_Missense_Mutation_p.H326D|MBTD1_uc002itq.3_3'UTR	NM_017643	NP_060113	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	490	MBT 4.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			CGAAATCCGTGATTTGGAACA	0.378													20	99					0	0	0	0	C	49270365	C	C	49270365	3	2	193	1	0	0	0	0	1	0	0	0	9413	1290	45	2	430	2	MBTD1	17	49270365	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	41692130	49270365	31924845	85	35474											
ANKFN1	162282	broad.mit.edu	37	chr17	54428211	54428211	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtgctccctcatctcccaaCgcagccaaacgcctgtacag	10	7	7	17	2	2	0	1	0	1	0	4	0	3	0	4	0	5	3	4	0	3	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:54428211C>T	uc002iun.1	+	4	317	c.282C>T	c.(280-282)AAC>AAT	p.N94N		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	94										large_intestine(1)|ovary(1)	2						CATCTCCCAACGCAGCCAAAC	0.448													9	45					0	0	0	0	T	54428211	T	T	54428211	2	4	193	1	0	0	0	0	0	0	0	1	625	535	19	1		1	ANKFN1	17	54428211	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08	5157846	54428211	26766999	86	35475											
ABCA5	23461	broad.mit.edu	37	chr17	67270205	67270205	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatgggaaccacagcattttTaaaagagtgatgaaccaaaa	18	8	9	6	0	0	3	0	2	0	1	0	5	0	4	2	1	3	1	2	1	6	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:67270205T>C	uc002jif.2	-	19	3877	c.2659A>G	c.(2659-2661)AAA>GAA	p.K887E	ABCA5_uc002jic.2_Missense_Mutation_p.K110E|ABCA5_uc002jid.2_5'UTR|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Missense_Mutation_p.K887E|ABCA5_uc002jih.2_Missense_Mutation_p.K887E|ABCA5_uc010dfe.2_Missense_Mutation_p.K887E	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	887					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					ACAGCATTTTTAAAAGAGTGA	0.323													13	48					0	0	0	0	C	67270205	C	C	67270205	3	2	193	1	0	0	0	0	1	0	0	0	35	1763	61	5	2349	5	ABCA5	17	67270205	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	12841994	67270205	13925005	87	35476											
KCTD2	23510	broad.mit.edu	37	chr17	73059132	73059132	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gattcttcaggagagaggatCgcggatgtaaactaagaccc	13	8	12	8	2	2	2	1	0	1	2	3	7	2	5	1	3	1	1	1	3	3	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:73059132C>T	uc002jmp.2	+	6	849	c.782C>T	c.(781-783)TCG>TTG	p.S261L	KCTD2_uc010dfz.2_RNA|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	261						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					GAGAGAGGATCGCGGATGTAA	0.552													4	21					0	0	0	0	T	73059132	T	T	73059132	3	4	193	1	0	0	0	0	1	0	0	0	8146	893	31	1	804	1	KCTD2	17	73059132	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	5788927	73059132	8136078	88	35477											
CASKIN2	57513	broad.mit.edu	37	chr17	73500710	73500710	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttagtgccctcagagctctgCccgctgccggcactgcggat	5	9	12	15	3	2	1	1	0	1	1	2	2	2	2	3	2	5	3	3	2	1	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:73500710C>T	uc002joc.2	-	12	1807	c.1257G>A	c.(1255-1257)GGG>GGA	p.G419G	CASKIN2_uc010wsc.1_Silent_p.G337G	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	419						cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGAGCTCTGCCCGCTGCCGG	0.642													3	22					0	0	0	0	T	73500710	T	T	73500710	2	4	193	1	0	0	0	0	0	0	0	1	2679	726	26	4		4	CASKIN2	17	73500710	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08	441578	73500710	7694500	89	35478											
MC2R	4158	broad.mit.edu	37	chr18	13885391	13885391	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagccagcaggacgatcaGattctccaaaactccaacaa	16	5	6	14	1	2	1	1	0	1	1	4	3	3	2	3	1	4	1	3	1	4	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr18:13885391G>A	uc002ksp.1	-	2	304	c.127C>T	c.(127-129)CTG>TTG	p.L43L		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	43	Helical; Name=1; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	AGGACGATCAGATTCTCCAAA	0.428													11	30					0	0	0	0	A	13885391	A	A	13885391	2	1	193	1	0	0	0	0	0	0	0	1	9417	933	33	2		2	MC2R	18	13885391	Silent	SNP	G	TCGA-CV-6934-01A-11D-1912-08		13885391	64191857	90	35479											
OR4F17	81099	broad.mit.edu	37	chr19	110747	110748	+	Frame_Shift_Ins	INS	-	T	T																															agaccttcctatttatgttgINSttttttgtattctatggagg																										TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	f094c9d6-47ab-4e33-84cd-aeae08aaf264	g.chr19:110747_110748insT	uc002loc.1	+	1	69_70	c.69_70insT	c.(67-72)TTGTTTfs	p.L23fs	OR4F17_uc002lob.1_Frame_Shift_Ins_p.L23fs	NM_001005240	NP_001005240	Q8NGA8	O4F17_HUMAN	olfactory receptor, family 4, subfamily F,	23_24	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TATTTATGTTGTTTTTTGTATT	0.411													---	---	---								T	110748	T	T	110747	7	5	193	1	0	1	1	0	0	0	0	0	11116	1368	48	0	71	0	OR4F17	19	110747	Frame_Shift_Ins	INS	-	TCGA-CV-6934-01A-11D-1912-08		110747	59018236	91	35480											
YIPF2	78992	broad.mit.edu	37	chr19	11038315	11038315	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagcctgacctgtgaggtGtccacgtcaaagaagctctg	9	8	11	13	1	2	3	1	2	1	1	3	3	3	3	4	1	2	1	4	1	2	0			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:11038315G>A	uc002mqb.2	-	4	394	c.270C>T	c.(268-270)GAC>GAT	p.D90D	YIPF2_uc002mqc.2_Silent_p.D90D|C19orf52_uc002mqd.1_5'Flank	NM_024029	NP_076934	Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	90	Cytoplasmic (Potential).					integral to membrane|transport vesicle					0						CCTGTGAGGTGTCCACGTCAA	0.512													7	40					0	0	0	0	A	11038315	A	A	11038315	2	1	193	1	0	0	0	0	0	0	0	1	17546	1368	48	4		4	YIPF2	19	11038315	Silent	SNP	G	TCGA-CV-6934-01A-11D-1912-08	10927568	11038315	48090668	92	35481											
ZNF284	342909	broad.mit.edu	37	chr19	44590486	44590486	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatccatactggggagaaGccattcaaatgttatatatg	15	11	9	6	0	1	2	1	0	0	2	2	3	2	2	2	2	2	1	2	2	7	5			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:44590486G>A	uc002oyg.1	+	5	1071	c.855G>A	c.(853-855)AAG>AAA	p.K285K	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				CTGGGGAGAAGCCATTCAAAT	0.393													23	72					0	0	0	0	A	44590486	A	A	44590486	2	1	193	1	0	0	0	0	0	0	0	1	17888	962	34	4		4	ZNF284	19	44590486	Silent	SNP	G	TCGA-CV-6934-01A-11D-1912-08	33552171	44590486	14538497	93	35482											
CEACAM18	729767	broad.mit.edu	37	chr19	51986513	51986513	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaccccgtgacacagctgAtcatgtacatggacgtcagg	12	7	11	11	2	2	3	2	2	0	1	2	4	2	4	2	2	3	2	2	2	2	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:51986513A>T	uc002pwv.1	+	5	1099	c.1099A>T	c.(1099-1101)ATC>TTC	p.I367F		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	367	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GACACAGCTGATCATGTACAT	0.582													22	57					0	0	0	0	T	51986513	T	T	51986513	3	4	193	1	0	0	0	0	1	0	0	0	3204	333	12	5	1117	5	CEACAM18	19	51986513	Missense_Mutation	SNP	A	TCGA-CV-6934-01A-11D-1912-08	7396027	51986513	7142470	94	35483											
LENG8	114823	broad.mit.edu	37	chr19	54965698	54965698	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccctcagccctcaaatccCccacatggggctcacacgct	8	6	6	21	1	3	0	3	0	0	0	4	0	4	0	5	2	1	2	5	2	1	0			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:54965698C>T	uc002qfv.1	+	5	549	c.405C>T	c.(403-405)CCC>CCT	p.P135P	LENG8_uc002qfw.2_Silent_p.P172P			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	135							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		CCTCAAATCCCCCACATGGGG	0.687													4	24					0	0	0	0	T	54965698	T	T	54965698	2	4	193	1	0	0	0	0	0	0	0	1	8764	610	22	4		4	LENG8	19	54965698	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08	2979185	54965698	4163285	95	35484											
ZNF628	89887	broad.mit.edu	37	chr19	55995170	55995170	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acggtccagctccagcccgtGgccggccagctctccaattc	6	7	10	18	3	1	0	0	0	1	0	5	0	3	0	6	3	3	2	6	3	1	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:55995170G>A	uc002qld.2	+	3	3163	c.2598G>A	c.(2596-2598)GTG>GTA	p.V866V	NAT14_uc002qle.1_5'Flank	NM_033113	NP_149104	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	866						nucleus	DNA binding|zinc ion binding				0	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		TCCAGCCCGTGGCCGGCCAGC	0.647													6	42					0	0	0	0	A	55995170	A	A	55995170	2	1	193	1	0	0	0	0	0	0	0	1	18119	1335	47	4		4	ZNF628	19	55995170	Silent	SNP	G	TCGA-CV-6934-01A-11D-1912-08	1029472	55995170	3133813	96	35485											
ZNF154	7710	broad.mit.edu	37	chr19	58213526	58213526	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccccagtgtgaactcccCgatgttgaaggagtgcagac	9	9	11	12	1	1	3	0	2	1	1	3	5	2	4	4	1	2	2	4	1	2	1			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:58213526C>T	uc010euf.2	-	3	1031	c.791G>A	c.(790-792)CGG>CAG	p.R264Q	ZNF776_uc002qpx.2_Intron|ZNF154_uc002qpy.2_RNA	NM_001085384	NP_001078853	Q13106	ZN154_HUMAN	zinc finger protein 154	264	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTGAACTCCCCGATGTTGAAG	0.453													23	90					0	0	0	0	T	58213526	T	T	58213526	3	4	193	1	0	0	0	0	1	0	0	0	17802	652	23	1	526	1	ZNF154	19	58213526	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	2218356	58213526	915457	97	35486											
SIRPB1	10326	broad.mit.edu	37	chr20	1600540	1600540	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctccccagcagtagcgtCatcagcaggaaaggactagg	12	6	12	11	1	3	0	2	0	1	0	4	2	3	2	2	3	3	3	2	3	3	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr20:1600540C>A	uc010gai.2	-	1	150	c.51G>T	c.(49-51)ATG>ATT	p.M17I	SIRPB1_uc002wfk.3_Missense_Mutation_p.M17I|SIRPB1_uc002wfl.3_Missense_Mutation_p.M17I	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	17					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						GCAGTAGCGTCATCAGCAGGA	0.562													7	62					1.12685e-05	1.27964e-05	1	0	A	1600540	A	A	1600540	3	1	193	1	0	0	0	0	1	0	0	0	14398	826	29	2	2302	2	SIRPB1	20	1600540	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08		1600540	61424980	98	35487											
SEL1L2	80343	broad.mit.edu	37	chr20	13856702	13856702	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accttactggctgccatggaAaagtacttgaaggcagtagc	12	9	11	9	0	0	1	0	1	0	0	0	2	0	2	2	3	4	4	2	3	6	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr20:13856702A>T	uc010gcf.2	-	12	1168	c.1086T>A	c.(1084-1086)TTT>TTA	p.F362L	SEL1L2_uc002woq.3_Missense_Mutation_p.F223L|SEL1L2_uc010zrl.1_Missense_Mutation_p.F362L|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	362	Extracellular (Potential).|Sel1-like 6.					integral to membrane	binding			ovary(2)	2						CTGCCATGGAAAAGTACTTGA	0.393													42	110					0	0	0	0	T	13856702	T	T	13856702	3	4	193	1	0	0	0	0	1	0	0	0	14076	11	1	5	1016	5	SEL1L2	20	13856702	Missense_Mutation	SNP	A	TCGA-CV-6934-01A-11D-1912-08	12256162	13856702	49168818	99	35488											
ZDHHC8	29801	broad.mit.edu	37	chr22	20127696	20127696	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtcattggcctcactggcTtccatgtggtgctggtcact	4	14	11	12	0	3	0	3	0	0	0	4	0	4	0	2	4	1	2	2	4	0	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr22:20127696T>A	uc002zrq.2	+	5	722	c.616T>A	c.(616-618)TTC>ATC	p.F206I	ZDHHC8_uc002zrr.1_Missense_Mutation_p.F206I|ZDHHC8_uc010gsa.2_Intron	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	206	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					CCTCACTGGCTTCCATGTGGT	0.637													6	32					0	0	0	0	A	20127696	A	A	20127696	3	1	193	1	0	0	0	0	1	0	0	0	17688	1609	56	5	634	5	ZDHHC8	22	20127696	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08		20127696	31176870	100	35489											
MORC2	22880	broad.mit.edu	37	chr22	31333632	31333632	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtaacgcagctcactggatGggggctggttccagttggca	7	10	15	9	1	1	0	1	0	0	0	2	1	2	1	1	5	2	7	1	5	1	3			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr22:31333632G>A	uc003aje.1	-	16	2614	c.1250C>T	c.(1249-1251)CCG>CTG	p.P417L		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	479							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						CTCACTGGATGGGGGCTGGTT	0.547													10	58					0	0	0	0	A	31333632	A	A	31333632	3	1	193	1	0	0	0	0	1	0	0	0	9755	1348	47	4	1710	4	MORC2	22	31333632	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08	11205936	31333632	19970934	101	35490											
NUP50	10762	broad.mit.edu	37	chr22	45574201	45574201	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggacagtcagcagccctcCtcctctggccttgcttccag	5	9	11	16	0	2	0	1	0	1	0	5	1	5	1	5	3	3	2	5	3	0	2			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr22:45574201C>T	uc003bfr.2	+	5	885	c.423C>T	c.(421-423)TCC>TCT	p.S141S	NUP50_uc003bfs.2_Silent_p.S113S|NUP50_uc011aqn.1_5'UTR|NUP50_uc003bft.2_Silent_p.S113S|NUP50_uc011aqo.1_5'UTR	NM_007172	NP_009103	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa isoform b	141	5 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		AGCAGCCCTCCTCCTCTGGCC	0.483													10	40					0	0	0	0	T	45574201	T	T	45574201	2	4	193	1	0	0	0	0	0	0	0	1	10820	668	24	4		4	NUP50	22	45574201	Silent	SNP	C	TCGA-CV-6934-01A-11D-1912-08	14240569	45574201	5730365	102	35491											
TUBGCP6	85378	broad.mit.edu	37	chr22	50656424	50656444	+	In_Frame_Del	DEL	CCCCGCGGGCCCCCAGGGGGC	-	-																															caaagttggggtgctctgcaCcccgcgggcccccagggggc																								rs35381394	by1000genomes	TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr22:50656424_50656444delCCCCGCGGGCCCCCAGGGGGC	uc003bkb.1	-	24	5783_5803	c.5271_5291delGCCCCCTGGGGGCCCGCGGGG	c.(5269-5292)GGGCCCCCTGGGGGCCCGCGGGGT>GGT	p.1757_1764GPPGGPRG>G	TUBGCP6_uc003bka.1_In_Frame_Del_p.827_834GPPGGPRG>G|TUBGCP6_uc010har.1_In_Frame_Del_p.1749_1756GPPGGPRG>G|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1757_1764					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GTGCTCTGCACCCCGCGGGCCCCCAGGGGGCCCCCAGGCCT	0.624													---	---	---								-	50656444	-	-	50656424	7	5	193	1	0	1	0	1	0	0	0	0	16838	507	18	0	176	0	TUBGCP6	22	50656424	In_Frame_Del	DEL	CCCCGCGGGCCCCCAGGGGGC	TCGA-CV-6934-01A-11D-1912-08	5082223	50656424	648142	103	35492											
MAOB	4129	broad.mit.edu	37	chrX	43698134	43698134	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctttacatggtggatcagacGctcaacctcattcactttgt	9	14	7	11	1	4	1	4	0	0	1	4	2	4	2	1	2	2	1	1	2	2	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chrX:43698134G>A	uc004dfz.3	-	3	435	c.259C>T	c.(259-261)CGT>TGT	p.R87C	MAOB_uc011mkx.1_Missense_Mutation_p.R71C|MAOB_uc011mky.1_Missense_Mutation_p.R71C|MAOB_uc010nhj.2_Missense_Mutation_p.R87C	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	87	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	TGGATCAGACGCTCAACCTCA	0.433													18	82					0	0	0	0	A	43698134	A	A	43698134	3	1	193	1	0	0	0	0	1	0	0	0	9279	1087	38	1	1355	1	MAOB	23	43698134	Missense_Mutation	SNP	G	TCGA-CV-6934-01A-11D-1912-08		43698134	111572426	104	35493											
CCNB3	85417	broad.mit.edu	37	chrX	50052074	50052074	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatgccactttaggaagcCaccagtattgcagacaacca	14	8	8	11	0	0	1	0	0	0	1	0	3	0	2	4	1	4	2	4	1	5	5			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chrX:50052074C>G	uc004dox.3	+	6	1203	c.905C>G	c.(904-906)CCA>CGA	p.P302R	CCNB3_uc004doy.2_Missense_Mutation_p.P302R|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	302					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TTTAGGAAGCCACCAGTATTG	0.418													7	73					0	0	0	0	G	50052074	G	G	50052074	3	3	193	1	0	0	0	0	1	0	0	0	2929	594	21	4	919	4	CCNB3	23	50052074	Missense_Mutation	SNP	C	TCGA-CV-6934-01A-11D-1912-08	6353940	50052074	105218486	105	35494											
ATG4A	115201	broad.mit.edu	37	chrX	107393409	107393409	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcatcttcttggaccctcAtacaacccagacctttgttg	8	13	6	14	0	4	1	2	0	2	1	4	2	4	2	3	1	2	2	3	1	2	5			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chrX:107393409A>G	uc004enr.2	+	10	965	c.842A>G	c.(841-843)CAT>CGT	p.H281R	ATG4A_uc004ent.2_Missense_Mutation_p.H219R|ATG4A_uc004ens.2_Missense_Mutation_p.H197R|ATG4A_uc011msl.1_Missense_Mutation_p.H135R|ATG4A_uc010npi.2_RNA|ATG4A_uc004enu.2_Missense_Mutation_p.H197R|COL4A6_uc011msm.1_Intron	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	281		By similarity.			autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1						TTGGACCCTCATACAACCCAG	0.493													70	200					0	0	0	0	G	107393409	G	G	107393409	3	3	193	1	0	0	0	0	1	0	0	0	1098	217	8	5	880	5	ATG4A	23	107393409	Missense_Mutation	SNP	A	TCGA-CV-6934-01A-11D-1912-08	57341335	107393409	47877151	106	35495											
GPR112	139378	broad.mit.edu	37	chrX	135430046	135430046	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatatactcccaggactgTggaaatgatagtaaactcca	15	9	8	9	0	0	1	0	1	0	0	2	3	2	3	2	2	3	2	2	2	6	4			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chrX:135430046T>C	uc004ezu.1	+	6	4472	c.4181T>C	c.(4180-4182)GTG>GCG	p.V1394A	GPR112_uc010nsb.1_Missense_Mutation_p.V1189A|GPR112_uc010nsc.1_Missense_Mutation_p.V1161A	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1394	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CCCAGGACTGTGGAAATGATA	0.453													49	175					0	0	0	0	C	135430046	C	C	135430046	3	2	193	1	0	0	0	0	1	0	0	0	6667	1696	59	5	4191	5	GPR112	23	135430046	Missense_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	28036637	135430046	19840514	107	35496											
MAGEA5	4104	broad.mit.edu	37	chrX	151283638	151283638	+	Nonstop_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgtgaccggctccttgacTtaatacttgaggagcagaaa	11	12	10	8	1	0	4	0	3	0	1	1	5	1	5	2	2	2	2	2	2	3	5			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chrX:151283638T>G	uc004ffj.2	-	3	580	c.375A>C	c.(373-375)TAA>TAC	p.*125Y		NM_021049	NP_066387	P43359	MAGA5_HUMAN	melanoma antigen family A, 5	125											0	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCCTTGACTTAATACTTGA	0.512													34	136					0	0	0	0	G	151283638	G	G	151283638	4	3	193	1	0	0	0	0	0	0	0	0	9220	1616	56	5	3	5	MAGEA5	23	151283638	Nonstop_Mutation	SNP	T	TCGA-CV-6934-01A-11D-1912-08	15853592	151283638	3986922	108	35497											
PRAMEF10	343071	broad.mit.edu	37	chr1	12955542	12955542	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagggcctcaaaacgtctcAtgctgaaggcctccatgaac	11	8	9	13	1	3	2	3	2	1	0	5	2	4	2	3	2	3	1	3	2	4	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:12955542A>C	uc001auo.2	-	2	210	c.137T>G	c.(136-138)ATG>AGG	p.M46R		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	46											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAAACGTCTCATGCTGAAGGC	0.572													33	21					0	0	0	0	C	12955542	C	C	12955542	3	2	194	1	0	0	0	0	1	0	0	0	12486	217	8	5	1299	5	PRAMEF10	1	12955542	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08		12955542	236295079	1	35498											
DDI2	84301	broad.mit.edu	37	chr1	15956910	15956910	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaacacagcagtcccactCatctcctggagaaataactt	14	8	7	12	0	2	1	1	0	1	1	4	3	3	2	2	2	3	1	2	2	3	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:15956910C>T	uc001awx.1	+	3	455	c.359C>T	c.(358-360)TCA>TTA	p.S120L	DDI2_uc001aww.2_Missense_Mutation_p.S120L|DDI2_uc009voj.1_5'UTR	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	120					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CAGTCCCACTCATCTCCTGGA	0.542													33	15					0	0	0	0	T	15956910	T	T	15956910	3	4	194	1	0	0	0	0	1	0	0	0	4346	838	29	2	369	2	DDI2	1	15956910	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	3001368	15956910	233293711	2	35499											
CLCNKB	1188	broad.mit.edu	37	chr1	16380200	16380200	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactggccaaggacatgccActggaggaggtggtcaaggt	11	6	15	9	0	1	0	1	0	0	0	1	3	1	3	2	7	1	0	2	7	2	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:16380200A>G	uc001axw.3	+	16	1769	c.1689A>G	c.(1687-1689)CCA>CCG	p.P563P	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Silent_p.P563P|CLCNKB_uc001axy.3_Silent_p.P394P	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	563	CBS 1.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		AGGACATGCCACTGGAGGAGG	0.632													15	15					0	0	0	0	G	16380200	G	G	16380200	2	3	194	1	0	0	0	0	0	0	0	1	3485	146	6	5		5	CLCNKB	1	16380200	Silent	SNP	A	TCGA-CV-6935-01A-11D-1912-08	423290	16380200	232870421	3	35500											
PABPC4	8761	broad.mit.edu	37	chr1	40030930	40030930	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttcctctgggccagggcaaCatatagtggcttggagccca	8	9	12	12	0	1	0	0	0	1	0	2	1	2	1	3	4	2	2	3	4	3	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:40030930C>A	uc010oiv.1	-	8	1991	c.1093G>T	c.(1093-1095)GTT>TTT	p.V365F	PABPC4_uc001cdl.2_Missense_Mutation_p.V365F|PABPC4_uc001cdm.2_Missense_Mutation_p.V365F	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	365	RRM 4.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GCCAGGGCAACATATAGTGGC	0.507													30	17					8.4185e-14	1.17529e-13	1	0	A	40030930	A	A	40030930	3	1	194	1	0	0	0	0	1	0	0	0	11420	478	17	4	921	4	PABPC4	1	40030930	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	23650730	40030930	209219691	4	35501											
STIL	6491	broad.mit.edu	37	chr1	47717390	47717390	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tctgtattaatatggagaagGctgaatgggtcacaattatt	13	14	10	4	0	2	2	1	1	1	1	2	3	2	2	0	3	0	2	0	3	7	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:47717390G>A	uc001crc.1	-	17	3437	c.3282C>T	c.(3280-3282)AGC>AGT	p.S1094S	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Silent_p.S1048S|STIL_uc010omo.1_Silent_p.S1077S|STIL_uc001crd.1_Silent_p.S1095S|STIL_uc001cre.1_Silent_p.S1094S	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1094					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TATGGAGAAGGCTGAATGGGT	0.373													69	42					0	0	0	0	A	47717390	A	A	47717390	2	1	194	1	0	0	0	0	0	0	0	1	15348	1194	42	4		4	STIL	1	47717390	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	7686460	47717390	201533231	5	35502											
C1orf83	127428	broad.mit.edu	37	chr1	54562036	54562036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattaatgggccgtaccggCggacggtgagagccctggtc	7	8	15	11	4	1	1	1	1	0	1	2	3	1	2	3	5	2	1	3	5	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:54562036C>T	uc001cwt.1	+	5	717	c.517C>T	c.(517-519)CGG>TGG	p.R173W	C1orf83_uc001cwu.1_RNA	NM_153035	NP_694580	Q96MN5	TEAN2_HUMAN	hypothetical protein LOC127428	173	TFIIS central.				transcription, DNA-dependent	nucleus	DNA binding				0						GCCGTACCGGCGGACGGTGAG	0.512													38	20					0	0	0	0	T	54562036	T	T	54562036	3	4	194	1	0	0	0	0	1	0	0	0	2070	759	27	1	531	1	C1orf83	1	54562036	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	6844646	54562036	194688585	6	35503											
LEPR	3953	broad.mit.edu	37	chr1	66081724	66081724	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgactcattgtgcagtgttCagagatatgtgataaaccat	13	13	9	6	0	2	3	2	2	0	1	2	4	2	3	1	0	2	2	1	0	3	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:66081724C>T	uc001dci.2	+	15	2231	c.2029C>T	c.(2029-2031)CAG>TAG	p.Q677*	LEPR_uc001dcg.2_Nonsense_Mutation_p.Q677*|LEPR_uc001dch.2_Nonsense_Mutation_p.Q677*|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Nonsense_Mutation_p.Q677*|LEPR_uc001dck.2_Nonsense_Mutation_p.Q677*	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	677	Extracellular (Potential).|Fibronectin type-III 3.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GTGCAGTGTTCAGAGATATGT	0.393													15	15					0	0	0	0	T	66081724	T	T	66081724	4	4	194	1	0	0	0	0	0	1	0	0	8768	827	29	2	2079	2	LEPR	1	66081724	Nonsense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	11519688	66081724	183168897	7	35504											
C1orf173	127254	broad.mit.edu	37	chr1	75037100	75037100	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccagggctcctggagtgcCcaccccagcctctgttgtat	5	10	10	16	0	1	0	0	0	1	0	3	1	3	1	6	2	2	3	6	2	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:75037100C>A	uc001dgg.2	-	14	4513	c.4294G>T	c.(4294-4296)GGC>TGC	p.G1432C		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1432	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTGGAGTGCCCACCCCAGCC	0.612													58	33					2.43698e-19	3.69176e-19	1	0	A	75037100	A	A	75037100	3	1	194	1	0	0	0	0	1	0	0	0	2023	623	22	4	302	4	C1orf173	1	75037100	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	8955376	75037100	174213521	8	35505											
AGL	178	broad.mit.edu	37	chr1	100327061	100327061	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catgtgctttttatttagggTatgagctacagttccgatta	9	17	9	6	1	0	1	0	1	0	0	1	2	1	1	1	1	3	4	1	1	5	9			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:100327061T>C	uc001dsi.1	+	3	485	c.85T>C	c.(85-87)TAT>CAT	p.Y29H	AGL_uc001dsj.1_Missense_Mutation_p.Y29H|AGL_uc001dsk.1_Missense_Mutation_p.Y29H|AGL_uc001dsl.1_Missense_Mutation_p.Y29H|AGL_uc001dsm.1_Missense_Mutation_p.Y13H|AGL_uc001dsn.1_Missense_Mutation_p.Y12H	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	29	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TTATTTAGGGTATGAGCTACA	0.308													12	9					0	0	0	0	C	100327061	C	C	100327061	3	2	194	1	0	0	0	0	1	0	0	0	384	1638	57	5	160	5	AGL	1	100327061	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	25289961	100327061	148923560	9	35506											
MAGI3	260425	broad.mit.edu	37	chr1	114216018	114216018	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcctccgaggggggaaggaGtacaacatggggctgttcat	10	7	16	8	1	1	0	1	0	0	0	2	3	2	2	2	6	3	3	2	6	3	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:114216018G>A	uc001edk.2	+	19	3301	c.3120G>A	c.(3118-3120)GAG>GAA	p.E1040E	MAGI3_uc001edh.3_Silent_p.E1065E|MAGI3_uc001edi.3_Silent_p.E1040E|MAGI3_uc010owm.1_Silent_p.E1065E|MAGI3_uc001edj.2_Silent_p.E761E	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1065	PDZ 6.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGGGAAGGAGTACAACATGG	0.488													64	39					0	0	0	0	A	114216018	A	A	114216018	2	1	194	1	0	0	0	0	0	0	0	1	9245	1020	36	4		4	MAGI3	1	114216018	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	13888957	114216018	135034603	10	35507											
MTMR11	10903	broad.mit.edu	37	chr1	149905389	149905389	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgtctaccaggacaacatCtgaatgcccagcctggagca	12	7	10	12	0	2	1	0	1	2	0	2	3	2	3	3	2	5	1	3	2	3	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:149905389C>T	uc001etl.3	-	10	1146	c.895G>A	c.(895-897)GAT>AAT	p.D299N	MTMR11_uc001etm.1_Missense_Mutation_p.D227N|MTMR11_uc010pbm.1_Missense_Mutation_p.D271N|MTMR11_uc010pbn.1_Missense_Mutation_p.D141N	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	299	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			AGGACAACATCTGAATGCCCA	0.547													31	105					0	0	0	0	T	149905389	T	T	149905389	3	4	194	1	0	0	0	0	1	0	0	0	9993	913	32	2	1305	2	MTMR11	1	149905389	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	35689371	149905389	99345232	11	35508											
RFX5	5993	broad.mit.edu	37	chr1	151315026	151315026	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtctcccatggtaaccttGaggactgggcagattccatg	9	11	11	10	0	1	2	0	1	1	1	3	3	2	3	3	3	1	2	3	3	1	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:151315026G>C	uc001exv.1	-	11	1701	c.1487C>G	c.(1486-1488)TCA>TGA	p.S496*	RFX5_uc001exw.1_Nonsense_Mutation_p.S496*|RFX5_uc009wmr.1_Nonsense_Mutation_p.S496*|RFX5_uc010pcx.1_Nonsense_Mutation_p.S456*	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	496						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGGTAACCTTGAGGACTGGGC	0.577													83	194					0	0	0	0	C	151315026	C	C	151315026	4	2	194	1	0	0	0	0	0	1	0	0	13331	1294	45	2	367	2	RFX5	1	151315026	Nonsense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	1409637	151315026	97935595	12	35509											
NUP210L	91181	broad.mit.edu	37	chr1	154034118	154034118	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gactccaatcagtacagtccCttttatctgatgtactttaa	11	15	5	10	0	2	1	1	1	1	0	4	2	4	1	2	0	2	2	2	0	5	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:154034118C>T	uc001fdw.2	-	18	2659	c.2587G>A	c.(2587-2589)GGG>AGG	p.G863R	NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Missense_Mutation_p.G863R	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	863						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AGTACAGTCCCTTTTATCTGA	0.338													27	53					0	0	0	0	T	154034118	T	T	154034118	3	4	194	1	0	0	0	0	1	0	0	0	10815	681	24	4	3171	4	NUP210L	1	154034118	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	2719092	154034118	95216503	13	35510											
OR6K2	81448	broad.mit.edu	37	chr1	158669597	158669597	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggggttgaagaagggagaCaaaactgcaaaggccagagc	16	4	15	6	0	0	4	0	1	0	3	0	5	0	4	1	4	3	2	1	4	5	1	rs141159720	byFrequency	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:158669597C>G	uc001fsu.1	-	1	846	c.846G>C	c.(844-846)TTG>TTC	p.L282F		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGAAGGGAGACAAAACTGCAA	0.403													10	29					0	0	0	0	G	158669597	G	G	158669597	3	3	194	1	0	0	0	0	1	0	0	0	11256	477	17	4	132	4	OR6K2	1	158669597	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	4635479	158669597	90581024	14	35511											
ARHGAP30	257106	broad.mit.edu	37	chr1	161022564	161022564	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggtccctggaagcgatcGccacccactctccacctcac	7	6	8	20	3	2	0	1	0	1	0	5	2	3	1	6	2	1	0	6	2	1	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:161022564G>A	uc001fxl.2	-	7	1034	c.688C>T	c.(688-690)CGA>TGA	p.R230*	ARHGAP30_uc001fxk.2_Nonsense_Mutation_p.R230*|ARHGAP30_uc001fxm.2_Nonsense_Mutation_p.R76*|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_Nonsense_Mutation_p.R76*	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	230					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GGAAGCGATCGCCACCCACTC	0.607													27	39					0	0	0	0	A	161022564	A	A	161022564	4	1	194	1	0	0	0	0	0	1	0	0	879	1095	38	1	2641	1	ARHGAP30	1	161022564	Nonsense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	2352967	161022564	88228057	15	35512											
DUSP12	11266	broad.mit.edu	37	chr1	161719654	161719654	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccccagcgccagcagagtCagctgtgccgggcagatgct	9	5	13	14	2	1	2	1	0	0	2	1	2	1	2	4	1	6	4	4	1	1	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:161719654C>T	uc001gbo.2	+	1	74	c.63C>T	c.(61-63)GTC>GTT	p.V21V	DUSP12_uc001gbp.2_5'UTR	NM_007240	NP_009171	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	21					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)	1	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CCAGCAGAGTCAGCTGTGCCG	0.672													4	16					0	0	0	0	T	161719654	T	T	161719654	2	4	194	1	0	0	0	0	0	0	0	1	4834	813	29	2		2	DUSP12	1	161719654	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	697090	161719654	87530967	16	35513											
C1orf114	57821	broad.mit.edu	37	chr1	169390813	169390813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcgatataagccagcggctCtcctgttgatgagtgagtga	10	10	13	8	2	1	4	0	4	1	0	2	5	1	4	2	1	3	2	2	1	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:169390813C>T	uc001gga.1	-	3	1024	c.856G>A	c.(856-858)GAG>AAG	p.E286K	C1orf114_uc001gfz.1_Missense_Mutation_p.E286K|C1orf114_uc009wvq.1_Missense_Mutation_p.E286K|C1orf114_uc001ggb.2_Missense_Mutation_p.E286K|C1orf114_uc001ggc.1_Missense_Mutation_p.E286K	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	286											0	all_hematologic(923;0.208)					GCCAGCGGCTCTCCTGTTGAT	0.473													53	142					0	0	0	0	T	169390813	T	T	169390813	3	4	194	1	0	0	0	0	1	0	0	0	1996	922	32	2	686	2	C1orf114	1	169390813	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	7671159	169390813	79859808	17	35514											
PRRX1	5396	broad.mit.edu	37	chr1	170688866	170688866	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcattgtgttctattccaGatgaccagctgaactcagaa	12	12	7	10	0	3	4	2	2	1	2	4	4	4	4	2	0	2	2	2	0	3	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:170688866G>C	uc001ghf.2	+	2	289	c.242_splice	c.e2-1	p.N81_splice	PRRX1_uc001ghe.2_Splice_Site_p.N81_splice	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTCTATTCCAGATGACCAGCT	0.408													14	19					0	0	0	0	C	170688866	C	C	170688866	5	2	194	1	0	0	0	0	0	0	1	0	12674	956	33	2	247	2	PRRX1	1	170688866	Splice_Site	SNP	G	TCGA-CV-6935-01A-11D-1912-08	1298053	170688866	78561755	18	35515											
BAT2L2	23215	broad.mit.edu	37	chr1	171509618	171509618	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaccaagctctaacagaaggGaagaagttaatgatagacct	17	7	10	7	0	1	4	0	1	1	3	1	6	1	5	2	1	2	2	2	1	7	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:171509618G>T	uc010pmg.1	+	16	3273	c.3007G>T	c.(3007-3009)GAA>TAA	p.E1003*	BAT2L2_uc010pmh.1_5'UTR	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1003							protein C-terminus binding				0						TAACAGAAGGGAAGAAGTTAA	0.413													17	16					1.02788e-11	1.39136e-11	1	0	T	171509618	T	T	171509618	4	4	194	1	0	0	0	0	0	1	0	0	1323	1175	41	2	3065	2	BAT2L2	1	171509618	Nonsense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	820752	171509618	77741003	19	35516											
TNR	7143	broad.mit.edu	37	chr1	175362961	175362962	+	Frame_Shift_Ins	INS	-	A	A																															catcgaaggaaaatgagaagINSggctcccactgcacctccac																										TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:175362961_175362962insA	uc001gkp.1	-	4	1391_1392	c.1310_1311insT	c.(1309-1311)CCCfs	p.P437fs	TNR_uc009wwu.1_Frame_Shift_Ins_p.P437fs|TNR_uc010pmz.1_3'UTR	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	437	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					AAAATGAGAAGGGCTCCCACTG	0.455													---	---	---								A	175362962	A	A	175362961	7	5	194	1	0	1	1	0	0	0	0	0	16404	987	35	0	2837	0	TNR	1	175362961	Frame_Shift_Ins	INS	-	TCGA-CV-6935-01A-11D-1912-08	3853343	175362961	73887660	20	35517											
CACNA1E	777	broad.mit.edu	37	chr1	181680164	181680164	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggcgccagcagcagattgAgcgtgagctgaatggctacc	9	6	15	11	3	0	4	0	3	0	1	0	4	0	4	2	2	5	4	2	2	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:181680164A>G	uc001gow.2	+	8	1295	c.1130A>G	c.(1129-1131)GAG>GGG	p.E377G	CACNA1E_uc009wxs.2_Missense_Mutation_p.E284G	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	377	Cytoplasmic (Potential).|Binding to the beta subunit (By similarity).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CAGCAGATTGAGCGTGAGCTG	0.577													39	98					0	0	0	0	G	181680164	G	G	181680164	3	3	194	1	0	0	0	0	1	0	0	0	2554	304	11	5	1160	5	CACNA1E	1	181680164	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	6317203	181680164	67570457	21	35518											
IVNS1ABP	10625	broad.mit.edu	37	chr1	185276680	185276680	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatttgtaacaaatgctcctGaatataagcatcaaccttat	16	13	4	8	0	1	1	1	1	0	0	2	1	2	1	2	0	4	3	2	0	8	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:185276680G>C	uc001grl.2	-	6	1095	c.472C>G	c.(472-474)CAG>GAG	p.Q158E	IVNS1ABP_uc001grj.2_5'Flank|IVNS1ABP_uc009wyj.2_5'UTR|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	158	BACK.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						AAATGCTCCTGAATATAAGCA	0.363													25	70					0	0	0	0	C	185276680	C	C	185276680	3	2	194	1	0	0	0	0	1	0	0	0	7969	1299	45	2	1496	2	IVNS1ABP	1	185276680	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	3596516	185276680	63973941	22	35519											
HMCN1	83872	broad.mit.edu	37	chr1	185946936	185946936	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagcacctccagttttcataCaagaacctgctgatgtgtct	10	12	7	12	0	2	2	1	1	1	1	3	2	3	2	3	0	4	3	3	0	3	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:185946936C>T	uc001grq.1	+	16	2618	c.2389C>T	c.(2389-2391)CAA>TAA	p.Q797*	HMCN1_uc001grr.1_Nonsense_Mutation_p.Q138*	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	797	Ig-like C2-type 5.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGTTTTCATACAAGAACCTGC	0.343													49	61					0	0	0	0	T	185946936	T	T	185946936	4	4	194	1	0	0	0	0	0	1	0	0	7259	479	17	4	2451	4	HMCN1	1	185946936	Nonsense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	670256	185946936	63303685	23	35520											
CRB1	23418	broad.mit.edu	37	chr1	197390341	197390355	+	In_Frame_Del	DEL	AGATGGCCAGCATGG	-	-																															acatgcatccctcacttccaAgatggccagcatggattcag																										TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:197390341_197390355delAGATGGCCAGCATGG	uc001gtz.2	+	6	1518_1532	c.1383_1397delAGATGGCCAGCATGG	c.(1381-1398)CAAGATGGCCAGCATGGA>CAA	p.DGQHG462del	CRB1_uc010poz.1_In_Frame_Del_p.DGQHG393del|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_In_Frame_Del_p.DGQHG350del|CRB1_uc010ppb.1_In_Frame_Del_p.DGQHG462del|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_In_Frame_Del_p.DGQHG111del	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	462_466	Extracellular (Potential).|EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CTCACTTCCAAGATGGCCAGCATGGATTCAGCTGC	0.484													---	---	---								-	197390355	-	-	197390341	7	5	194	1	0	1	0	1	0	0	0	0	3863	69	3	0	1405	0	CRB1	1	197390341	In_Frame_Del	DEL	AGATGGCCAGCATGG	TCGA-CV-6935-01A-11D-1912-08	11443405	197390341	51860280	24	35521											
PRELP	5549	broad.mit.edu	37	chr1	203452824	203452824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtcccctcggccctgccccGgaacctggagcagctgaggc	5	5	14	17	2	0	1	0	1	0	0	2	3	1	3	6	5	4	2	6	5	1	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:203452824G>A	uc001gzs.2	+	2	712	c.512G>A	c.(511-513)CGG>CAG	p.R171Q	PRELP_uc001gzt.2_Missense_Mutation_p.R171Q	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	171	LRR 4.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCCCTGCCCCGGAACCTGGAG	0.597													5	149					0	0	0	0	A	203452824	A	A	203452824	3	1	194	1	0	0	0	0	1	0	0	0	12535	1116	39	1	514	1	PRELP	1	203452824	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	6062483	203452824	45797797	25	35522											
RYR2	6262	broad.mit.edu	37	chr1	237660034	237660034	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttctcctatggatttgatGgccttcatctctggtcaggt	5	17	9	10	0	5	1	2	1	3	0	7	2	5	2	2	4	0	0	2	4	1	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:237660034G>C	uc001hyl.1	+	20	2305	c.2185G>C	c.(2185-2187)GGC>CGC	p.G729R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	729	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGATTTGATGGCCTTCATCT	0.493													65	188					0	0	0	0	C	237660034	C	C	237660034	3	2	194	1	0	0	0	0	1	0	0	0	13834	1348	47	4	2263	4	RYR2	1	237660034	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	34207210	237660034	11590587	26	35523											
RYR2	6262	broad.mit.edu	37	chr1	237865319	237865319	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttatagaattctgactagcTtatatgctttgggaaccagc	11	14	9	7	0	1	2	0	1	1	1	1	3	1	3	1	1	4	3	1	1	7	7			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:237865319T>A	uc001hyl.1	+	66	9529	c.9409T>A	c.(9409-9411)TTA>ATA	p.L3137I	RYR2_uc010pxz.1_Missense_Mutation_p.L92I	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3137					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTGACTAGCTTATATGCTTT	0.328													32	16					0	0	0	0	A	237865319	A	A	237865319	3	1	194	1	0	0	0	0	1	0	0	0	13834	1606	56	5	9671	5	RYR2	1	237865319	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	205285	237865319	11385302	27	35524											
FMN2	56776	broad.mit.edu	37	chr1	240370643	240370643	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaaccagccacgaacactCtgtttcctctgcctttaaaa	12	11	4	14	1	3	0	1	0	2	0	4	1	4	0	4	0	4	1	4	0	4	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:240370643C>T	uc010pyd.1	+	5	2756	c.2531C>T	c.(2530-2532)TCT>TTT	p.S844F	FMN2_uc010pye.1_Missense_Mutation_p.S848F	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	844	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CACGAACACTCTGTTTCCTCT	0.562													73	68					0	0	0	0	T	240370643	T	T	240370643	3	4	194	1	0	0	0	0	1	0	0	0	5982	913	32	2	2549	2	FMN2	1	240370643	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	2505324	240370643	8879978	28	35525											
RGS7	6000	broad.mit.edu	37	chr1	240964780	240964780	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgtgcaaatttttcaaaaGatgttctgcgatccattgag	11	15	8	7	1	3	2	1	1	2	1	4	3	4	2	1	0	2	2	1	0	3	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:240964780G>C	uc001hyv.2	-	17	1718	c.1388C>G	c.(1387-1389)TCT>TGT	p.S463C	RGS7_uc010pyh.1_Intron|RGS7_uc010pyj.1_Intron|RGS7_uc001hyu.2_Intron|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Intron|RGS7_uc001hyt.2_Missense_Mutation_p.S295C	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	463					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TTTTTCAAAAGATGTTCTGCG	0.239													10	18					0	0	0	0	C	240964780	C	C	240964780	3	2	194	1	0	0	0	0	1	0	0	0	13375	942	33	2	83	2	RGS7	1	240964780	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	594137	240964780	8285841	29	35526											
KIF26B	55083	broad.mit.edu	37	chr1	245849620	245849620	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccctcgagcaaggattccgGcgtggcgtctagggagtcct	6	9	14	12	4	1	0	0	0	1	0	5	3	4	2	3	4	1	1	3	4	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:245849620G>T	uc001ibf.1	+	12	3775	c.3335G>T	c.(3334-3336)GGC>GTC	p.G1112V	KIF26B_uc001ibg.1_Missense_Mutation_p.G730V|KIF26B_uc001ibh.1_Missense_Mutation_p.G354V	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1112					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AAGGATTCCGGCGTGGCGTCT	0.612													56	125					3.31993e-32	5.42153e-32	1	0	T	245849620	T	T	245849620	3	4	194	1	0	0	0	0	1	0	0	0	8334	1203	42	4	3381	4	KIF26B	1	245849620	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	4884840	245849620	3401001	30	35527											
OR2T1	26696	broad.mit.edu	37	chr1	248569514	248569514	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttcaacagaaaggaaacCtcaggtcttatttttgccat	12	13	7	9	0	3	1	2	0	1	1	3	2	3	2	2	2	3	1	2	2	4	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:248569514C>A	uc010pzm.1	+	1	219	c.219C>A	c.(217-219)ACC>ACA	p.T73T		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	73	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAAAGGAAACCTCAGGTCTTA	0.423													83	73					1.20873e-29	1.9471e-29	1	0	A	248569514	A	A	248569514	2	1	194	1	0	0	0	0	0	0	0	1	11070	668	24	4		4	OR2T1	1	248569514	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	2719894	248569514	681107	31	35528											
OR2T3	343173	broad.mit.edu	37	chr1	248637225	248637225	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agactcctgccctgctgaagCtctcctgctctgacgtctcc	5	11	8	17	1	3	3	0	2	3	1	6	3	4	3	4	0	4	3	4	0	1	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:248637225C>T	uc001iel.1	+	1	574	c.574C>T	c.(574-576)CTC>TTC	p.L192F		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGCTGAAGCTCTCCTGCTC	0.517													192	155					0	0	0	0	T	248637225	T	T	248637225	3	4	194	1	0	0	0	0	1	0	0	0	11077	797	28	4	576	4	OR2T3	1	248637225	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	67711	248637225	613396	32	35529											
OR2T3	343173	broad.mit.edu	37	chr1	248637239	248637239	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagctctcctgctctgaCgtctccctctataagacgct	7	12	7	15	2	4	3	0	2	4	1	6	3	4	3	2	0	2	3	2	0	3	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:248637239C>G	uc001iel.1	+	1	588	c.588C>G	c.(586-588)GAC>GAG	p.D196E		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGCTCTGACGTCTCCCTCT	0.522													107	273					0	0	0	0	G	248637239	G	G	248637239	3	3	194	1	0	0	0	0	1	0	0	0	11077	535	19	3	590	3	OR2T3	1	248637239	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	14	248637239	613382	33	35530											
KIDINS220	57498	broad.mit.edu	37	chr2	8936972	8936972	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcaatgtttctcatcttggTagcctttataagtggcgttt	7	19	8	7	1	3	0	2	0	2	0	4	0	3	0	1	2	1	3	1	2	4	8			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:8936972T>C	uc002qzc.2	-	11	1209	c.1027A>G	c.(1027-1029)ACC>GCC	p.T343A	KIDINS220_uc010yiv.1_Missense_Mutation_p.T109A|KIDINS220_uc002qzd.2_Missense_Mutation_p.T301A|KIDINS220_uc010yiw.1_Missense_Mutation_p.T344A	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	343	Cytoplasmic (Potential).|ANK 11.				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTCATCTTGGTAGCCTTTATA	0.418													64	121					0	0	0	0	C	8936972	C	C	8936972	3	2	194	1	0	0	0	0	1	0	0	0	8310	1638	57	5	4368	5	KIDINS220	2	8936972	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08		8936972	234262401	34	35531											
APOB	338	broad.mit.edu	37	chr2	21228818	21228818	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggctctggaaagacccaGaatgaatccggacttcattt	11	10	9	11	1	2	3	1	1	1	2	3	5	3	5	3	3	0	1	3	3	3	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:21228818G>T	uc002red.2	-	26	11050	c.10922C>A	c.(10921-10923)TCT>TAT	p.S3641Y		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3641					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GAAAGACCCAGAATGAATCCG	0.463													14	26					1.5842e-08	2.05082e-08	1	0	T	21228818	T	T	21228818	3	4	194	1	0	0	0	0	1	0	0	0	785	942	33	2	2785	2	APOB	2	21228818	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	12291846	21228818	221970555	35	35532											
BIRC6	57448	broad.mit.edu	37	chr2	32728276	32728276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttctgagcctgacaatgctGaagggattcataactttgca	11	12	9	9	0	2	3	1	3	1	0	2	4	2	4	1	1	4	2	1	1	3	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:32728276G>A	uc010ezu.2	+	49	9606	c.9472G>A	c.(9472-9474)GAA>AAA	p.E3158K		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3158					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TGACAATGCTGAAGGGATTCA	0.338													7	17					0	0	0	0	A	32728276	A	A	32728276	3	1	194	1	0	0	0	0	1	0	0	0	1441	1291	45	2	9666	2	BIRC6	2	32728276	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	11499458	32728276	210471097	36	35533											
LRRTM1	347730	broad.mit.edu	37	chr2	80529897	80529897	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcgtccaggacgtcctcgcCctgtgcgtactccgggctgg	3	8	15	15	5	0	0	0	0	0	0	4	1	3	1	4	4	2	2	4	4	1	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:80529897C>A	uc002sok.1	-	2	1318	c.1048G>T	c.(1048-1050)GGC>TGC	p.G350C	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	350	LRRCT.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						ACGTCCTCGCCCTGTGCGTAC	0.672										HNSCC(69;0.2)			14	20					1.5842e-08	2.05082e-08	1	0	A	80529897	A	A	80529897	3	1	194	1	0	0	0	0	1	0	0	0	9089	623	22	4	524	4	LRRTM1	2	80529897	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	47801621	80529897	162669476	37	35534											
MITD1	129531	broad.mit.edu	37	chr2	99797327	99797327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggagcagatcaatcccctCttggtaacacaccagagcct	12	7	8	14	0	2	2	1	0	1	2	3	3	3	3	4	2	3	2	4	2	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:99797327C>T	uc002szs.1	-	1	166	c.118G>A	c.(118-120)GAG>AAG	p.E40K	MRPL30_uc002szl.1_Intron|MRPL30_uc002szr.2_Intron|MRPL30_uc002szt.1_5'Flank|MRPL30_uc002szu.2_5'Flank|MRPL30_uc002szv.2_5'Flank	NM_138798	NP_620153	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport,	40	MIT.				protein transport	late endosome membrane				large_intestine(1)|ovary(1)	2						TCAATCCCCTCTTGGTAACAC	0.582													65	104					0	0	0	0	T	99797327	T	T	99797327	3	4	194	1	0	0	0	0	1	0	0	0	9648	922	32	2	659	2	MITD1	2	99797327	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	19267430	99797327	143402046	38	35535											
ARHGAP15	55843	broad.mit.edu	37	chr2	143913079	143913079	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgcagaaatctacaaattCtgatacttccgtggaaacac	15	11	6	9	1	2	2	0	1	2	1	3	3	3	3	1	1	4	1	1	1	6	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:143913079C>G	uc002tvm.3	+	2	171	c.20C>G	c.(19-21)TCT>TGT	p.S7C	ARHGAP15_uc010zbl.1_Missense_Mutation_p.S7C	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	7					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TCTACAAATTCTGATACTTCC	0.373													11	18					0	0	0	0	G	143913079	G	G	143913079	3	3	194	1	0	0	0	0	1	0	0	0	866	913	32	2	22	2	ARHGAP15	2	143913079	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	44115752	143913079	99286294	39	35536											
ARHGAP15	55843	broad.mit.edu	37	chr2	143913203	143913203	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatccatgatcctcaccgaTgtcgggaaggtcactgaacc	12	8	9	12	2	2	2	2	2	0	0	5	4	4	3	4	2	1	0	4	2	3	0	rs146989390	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:143913203T>C	uc002tvm.3	+	2	295	c.144T>C	c.(142-144)GAT>GAC	p.D48D	ARHGAP15_uc010zbl.1_Silent_p.D48D	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	48					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TCCTCACCGATGTCGGGAAGG	0.423													26	23					0	0	0	0	C	143913203	C	C	143913203	2	2	194	1	0	0	0	0	0	0	0	1	866	1461	51	5		5	ARHGAP15	2	143913203	Silent	SNP	T	TCGA-CV-6935-01A-11D-1912-08	124	143913203	99286170	40	35537											
KCNJ3	3760	broad.mit.edu	37	chr2	155711512	155711512	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actagatgatattactacaaAactaccatctaagctgcaga	17	10	5	9	0	1	3	0	1	1	2	1	3	1	3	1	0	6	2	1	0	8	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:155711512A>G	uc002tyv.1	+	3	1388	c.1193A>G	c.(1192-1194)AAA>AGA	p.K398R	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	398	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	ATTACTACAAAACTACCATCT	0.388													64	98					0	0	0	0	G	155711512	G	G	155711512	3	3	194	1	0	0	0	0	1	0	0	0	8091	14	1	5	1203	5	KCNJ3	2	155711512	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	11798309	155711512	87487861	41	35538											
SCN3A	6328	broad.mit.edu	37	chr2	165986510	165986510	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcacatggtttggccagcGacctccatacagtcccacat	10	8	9	14	1	0	0	0	0	0	0	2	1	2	0	4	3	2	2	4	3	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:165986510G>T	uc002ucx.2	-	17	3354	c.2862C>A	c.(2860-2862)GTC>GTA	p.V954V	SCN3A_uc002ucy.2_Silent_p.V905V|SCN3A_uc002ucz.2_Silent_p.V905V|SCN3A_uc002uda.1_Silent_p.V774V|SCN3A_uc002udb.1_Silent_p.V774V	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	954						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTTGGCCAGCGACCTCCATAC	0.468													188	143					3.0798e-103	5.24598e-103	1	0	T	165986510	T	T	165986510	2	4	194	1	0	0	0	0	0	0	0	1	13983	1045	37	3		3	SCN3A	2	165986510	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	10274998	165986510	77212863	42	35539											
NFE2L2	4780	broad.mit.edu	37	chr2	178098973	178098973	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccaagatctatatcttgcctCcaaagtatgtcaatcaaatc	14	12	4	11	0	4	1	2	0	2	1	6	1	5	1	3	0	1	1	3	0	7	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:178098973C>G	uc002ulh.3	-	2	627	c.72G>C	c.(70-72)TGG>TGC	p.W24C	NFE2L2_uc002ulg.3_Missense_Mutation_p.W8C|NFE2L2_uc010zfa.1_Missense_Mutation_p.W8C|NFE2L2_uc002uli.3_Missense_Mutation_p.W8C|NFE2L2_uc010fra.2_Missense_Mutation_p.W8C|NFE2L2_uc010frb.2_Missense_Mutation_p.W8C	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	24					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TATCTTGCCTCCAAAGTATGT	0.348			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			19	20					0	0	0	0	G	178098973	G	G	178098973	3	3	194	1	0	0	0	0	1	0	0	0	10422	856	30	2	1761	2	NFE2L2	2	178098973	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	12112463	178098973	65100400	43	35540											
TTN	7273	broad.mit.edu	37	chr2	179465721	179465721	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgcagttcttccacatcaCgcttattgcactgcctccag	8	13	6	14	1	2	0	1	0	1	0	4	0	4	0	3	0	3	4	3	0	1	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:179465721C>A	uc010zfg.1	-	237	48430	c.48206G>T	c.(48205-48207)CGT>CTT	p.R16069L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R9764L|TTN_uc010zfi.1_Missense_Mutation_p.R9697L|TTN_uc010zfj.1_Missense_Mutation_p.R9572L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16996							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCACATCACGCTTATTGCA	0.488													138	102					2.82259e-58	4.73982e-58	1	0	A	179465721	A	A	179465721	3	1	194	1	0	0	0	0	1	0	0	0	16803	536	19	3	52083	3	TTN	2	179465721	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	1366748	179465721	63733652	44	35541											
TTN	7273	broad.mit.edu	37	chr2	179596593	179596593	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggattgtgttatctttgaacCaagtgatctcaaagggagga	12	12	12	5	0	2	2	1	2	2	0	3	5	2	5	1	3	1	1	1	3	4	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:179596593C>G	uc010zfg.1	-	55	13501	c.13277G>C	c.(13276-13278)TGG>TCG	p.W4426S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.W1087S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5353							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTTTGAACCAAGTGATCTC	0.428													37	139					0	0	0	0	G	179596593	G	G	179596593	3	3	194	1	0	0	0	0	1	0	0	0	16803	595	21	4	87740	4	TTN	2	179596593	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	130872	179596593	63602780	45	35542											
CCDC150	284992	broad.mit.edu	37	chr2	197538986	197538986	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttgaatgaccaattgactAaaaagtgttcagagttgagc	14	13	9	5	0	1	5	1	4	0	1	1	5	1	5	1	0	1	2	1	0	5	6	rs36060491		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:197538986A>G	uc002utp.1	+	10	1186	c.1051A>G	c.(1051-1053)AAA>GAA	p.K351E	CCDC150_uc010zgq.1_RNA|CCDC150_uc010zgr.1_RNA|CCDC150_uc010zgs.1_Missense_Mutation_p.K19E	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	351											0						CCAATTGACTAAAAAGTGTTC	0.338													7	9					0	0	0	0	G	197538986	G	G	197538986	3	3	194	1	0	0	0	0	1	0	0	0	2797	363	13	5	1089	5	CCDC150	2	197538986	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	17942393	197538986	45660387	46	35543											
AOX1	316	broad.mit.edu	37	chr2	201468754	201468754	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttagacaagtccaaaactCttcgcagaagaggagtttct	13	12	8	8	1	2	3	0	0	2	3	4	4	3	4	1	1	1	2	1	1	5	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:201468754C>G	uc002uvx.2	+	8	704	c.603C>G	c.(601-603)CTC>CTG	p.L201L		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	201					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GTCCAAAACTCTTCGCAGAAG	0.303													32	30					0	0	0	0	G	201468754	G	G	201468754	2	3	194	1	0	0	0	0	0	0	0	1	729	900	32	2		2	AOX1	2	201468754	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	3929768	201468754	41730619	47	35544											
ZDBF2	57683	broad.mit.edu	37	chr2	207170044	207170044	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataggaaatctttacgcatGaattcagataagttggtttt	14	15	8	4	1	2	2	1	1	1	1	2	3	2	3	0	2	1	3	0	2	6	8			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:207170044G>C	uc002vbp.2	+	5	1042	c.792G>C	c.(790-792)ATG>ATC	p.M264I		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	264							nucleic acid binding|zinc ion binding			ovary(3)	3						CTTTACGCATGAATTCAGATA	0.388													30	25					0	0	0	0	C	207170044	C	C	207170044	3	2	194	1	0	0	0	0	1	0	0	0	17666	1290	45	2	802	2	ZDBF2	2	207170044	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	5701290	207170044	36029329	48	35545											
C2orf67	151050	broad.mit.edu	37	chr2	210893657	210893657	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacaatgttatctatgtcatAagagctctcacttctcaatc	12	14	4	11	0	4	1	3	0	3	1	7	1	4	1	0	0	1	2	0	0	5	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:210893657A>C	uc002vds.2	-	11	2516	c.2308T>G	c.(2308-2310)TAT>GAT	p.Y770D	C2orf67_uc002vdt.2_Missense_Mutation_p.Y728D	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	770										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		TCTATGTCATAAGAGCTCTCA	0.368													45	65					0	0	0	0	C	210893657	C	C	210893657	3	2	194	1	0	0	0	0	1	0	0	0	2196	362	13	5	675	5	C2orf67	2	210893657	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	3723613	210893657	32305716	49	35546											
CPS1	1373	broad.mit.edu	37	chr2	211473158	211473158	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaattaagaacgtcgtatccGggaagacatcagcctgtttt	13	11	9	8	3	1	2	1	0	0	2	3	3	2	3	2	1	2	2	2	1	5	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:211473158G>A	uc002vee.3	+	19	2398	c.2266G>A	c.(2266-2268)GGG>AGG	p.G756R	CPS1_uc010fur.2_Missense_Mutation_p.G762R|CPS1_uc010fus.2_Missense_Mutation_p.G305R	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	756					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CGTCGTATCCGGGAAGACATC	0.433													76	85					0	0	0	0	A	211473158	A	A	211473158	3	1	194	1	0	0	0	0	1	0	0	0	3838	1116	39	1	2362	1	CPS1	2	211473158	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	579501	211473158	31726215	50	35547											
TNS1	7145	broad.mit.edu	37	chr2	218751275	218751275	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcctttagactcaaagtTggggatgccgtgcatgatca	10	11	10	10	1	2	2	2	1	0	1	3	3	3	3	3	2	2	2	3	2	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:218751275T>A	uc002vgt.2	-	11	984	c.586A>T	c.(586-588)AAC>TAC	p.N196Y	TNS1_uc002vgr.2_Missense_Mutation_p.N196Y|TNS1_uc002vgs.2_Missense_Mutation_p.N196Y|TNS1_uc010zjv.1_Missense_Mutation_p.N196Y|TNS1_uc010fvj.1_Missense_Mutation_p.N264Y|TNS1_uc010fvk.1_Missense_Mutation_p.N321Y|TNS1_uc002vgu.3_Missense_Mutation_p.N227Y|TNS1_uc010fvi.1_5'Flank	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	196	C2 tensin-type.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GACTCAAAGTTGGGGATGCCG	0.522											OREG0015188	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	5					0	0	0	0	A	218751275	A	A	218751275	3	1	194	1	0	0	0	0	1	0	0	0	16409	1812	63	5	4713	5	TNS1	2	218751275	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	7278117	218751275	24448098	51	35548											
PTPRN	5798	broad.mit.edu	37	chr2	220164922	220164922	+	Frame_Shift_Del	DEL	G	-	-																															gcagtggggtgtccaggcatGggggatgtgcgggctggaag																										TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:220164922delG	uc002vkz.2	-	9	1310	c.1221delC	c.(1219-1221)CCCfs	p.P407fs	PTPRN_uc010zlc.1_Frame_Shift_Del_p.P317fs|PTPRN_uc002vla.2_Frame_Shift_Del_p.P407fs	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	407	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GTCCAGGCATGGGGGATGTGC	0.632													---	---	---								-	220164922	-	-	220164922	7	5	194	1	0	1	0	1	0	0	0	0	12872	1335	47	0	1778	0	PTPRN	2	220164922	Frame_Shift_Del	DEL	G	TCGA-CV-6935-01A-11D-1912-08	1413647	220164922	23034451	52	35549											
DOCK3	1795	broad.mit.edu	37	chr3	51400017	51400017	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgtctctgttctgtcctcGtcccaggcaagcccttcttc	5	13	7	16	2	3	0	0	0	3	0	8	0	5	0	3	1	2	2	3	1	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:51400017G>A	uc011bds.1	+	49	5228	c.5205G>A	c.(5203-5205)TCG>TCA	p.S1735S		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1735	Ser-rich.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TTCTGTCCTCGTCCCAGGCAA	0.557													32	18					0	0	0	0	A	51400017	A	A	51400017	2	1	194	1	0	0	0	0	0	0	0	1	4710	1132	40	1		1	DOCK3	3	51400017	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08		51400017	146622413	53	35550											
PDZRN3	23024	broad.mit.edu	37	chr3	73432909	73432909	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcaggcggtcccgcacgggCctcttggtgatgtagcgcgt	5	8	16	12	5	1	1	0	1	1	0	2	1	2	1	2	4	2	3	2	4	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:73432909C>A	uc003dpl.1	-	10	2904	c.2808G>T	c.(2806-2808)AGG>AGT	p.R936S	PDZRN3_uc011bgh.1_Missense_Mutation_p.R593S|PDZRN3_uc010hoe.1_Missense_Mutation_p.R634S|PDZRN3_uc011bgf.1_Missense_Mutation_p.R653S|PDZRN3_uc011bgg.1_Missense_Mutation_p.R656S	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	936							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CCCGCACGGGCCTCTTGGTGA	0.667													19	13					3.99206e-14	5.59517e-14	1	0	A	73432909	A	A	73432909	3	1	194	1	0	0	0	0	1	0	0	0	11763	738	26	4	396	4	PDZRN3	3	73432909	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	22032892	73432909	124589521	54	35551											
OR5H1	26341	broad.mit.edu	37	chr3	97852283	97852283	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggagcccatctcttctctGtctctttatactatggaccc	6	15	7	13	0	3	0	0	0	3	0	6	2	3	2	2	2	2	0	2	2	3	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:97852283G>T	uc011bgt.1	+	1	742	c.742G>T	c.(742-744)GTC>TTC	p.V248F		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TCTCTTCTCTGTCTCTTTATA	0.413													45	160					3.7052e-28	5.91503e-28	1	0	T	97852283	T	T	97852283	3	4	194	1	0	0	0	0	1	0	0	0	11213	1377	48	4	744	4	OR5H1	3	97852283	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	24419374	97852283	100170147	55	35552											
MORC1	27136	broad.mit.edu	37	chr3	108778707	108778707	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacatcttccaaagctctcTgtaatacatcctggagaaat	13	12	5	11	0	2	1	0	0	2	1	5	2	4	1	2	1	3	2	2	1	5	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:108778707T>G	uc003dxl.2	-	12	1064	c.977A>C	c.(976-978)CAG>CCG	p.Q326P	MORC1_uc011bhn.1_Missense_Mutation_p.Q326P	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	326	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CAAAGCTCTCTGTAATACATC	0.358													7	51					0	0	0	0	G	108778707	G	G	108778707	3	3	194	1	0	0	0	0	1	0	0	0	9754	1580	55	5	2045	5	MORC1	3	108778707	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	10926424	108778707	89243723	56	35553											
PLXNA1	5361	broad.mit.edu	37	chr3	126736700	126736700	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggagacgcaactgctgtgcGaggcgcccaacctcactggg	8	5	14	14	4	1	1	1	0	0	1	1	3	1	1	2	3	4	2	2	3	2	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:126736700G>A	uc003ejg.2	+	18	3560	c.3556G>A	c.(3556-3558)GAG>AAG	p.E1186K		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1209	Extracellular (Potential).|IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		ACTGCTGTGCGAGGCGCCCAA	0.662													22	71					0	0	0	0	A	126736700	A	A	126736700	3	1	194	1	0	0	0	0	1	0	0	0	12174	1059	37	1	3695	1	PLXNA1	3	126736700	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	17957993	126736700	71285730	57	35554											
ATP2C1	27032	broad.mit.edu	37	chr3	130698095	130698095	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttattatttcctaagttCttgctttggcttctggtcct	5	22	6	8	0	2	0	0	0	2	0	4	0	4	0	2	2	1	3	2	2	3	9			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:130698095C>T	uc003enl.2	+	19	1795	c.1573C>T	c.(1573-1575)CTT>TTT	p.L525F	ATP2C1_uc011blg.1_Missense_Mutation_p.L559F|ATP2C1_uc011blh.1_Missense_Mutation_p.L520F|ATP2C1_uc011bli.1_Missense_Mutation_p.L559F|ATP2C1_uc003enk.2_Missense_Mutation_p.L509F|ATP2C1_uc003enm.2_Missense_Mutation_p.L525F|ATP2C1_uc003enn.2_Missense_Mutation_p.L509F|ATP2C1_uc003eno.2_Missense_Mutation_p.L525F|ATP2C1_uc003enp.2_Missense_Mutation_p.L525F|ATP2C1_uc003enq.2_Missense_Mutation_p.L525F|ATP2C1_uc003enr.2_Missense_Mutation_p.L525F|ATP2C1_uc003ens.2_Missense_Mutation_p.L525F|ATP2C1_uc003ent.2_Missense_Mutation_p.L525F|ATP2C1_uc003enu.2_Missense_Mutation_p.L203F	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	525	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TTCCTAAGTTCTTGCTTTGGC	0.373									Hailey-Hailey_disease				8	164					0	0	0	0	T	130698095	T	T	130698095	3	4	194	1	0	0	0	0	1	0	0	0	1145	913	32	2	1643	2	ATP2C1	3	130698095	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	3961395	130698095	67324335	58	35555											
PLCH1	23007	broad.mit.edu	37	chr3	155203145	155203145	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaacttaaagcatcttacCtagagagttttcttttcctt	12	16	5	8	0	2	2	0	0	2	2	3	3	3	2	2	0	3	2	2	0	5	8			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:155203145C>T	uc011bok.1	-	22	3275	c.2998G>A	c.(2998-3000)GCA>ACA	p.A1000T	PLCH1_uc011boj.1_Missense_Mutation_p.V1000I|PLCH1_uc011bol.1_Missense_Mutation_p.A962T	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1000					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AGCATCTTACCTAGAGAGTTT	0.423													13	50					0	0	0	0	T	155203145	T	T	155203145	3	4	194	1	0	0	0	0	1	0	0	0	12092	695	24	4	2106	4	PLCH1	3	155203145	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	24505050	155203145	42819285	59	35556											
RSRC1	51319	broad.mit.edu	37	chr3	157920993	157920993	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaaaagagaaaaggagaaGgataaagggaaggacaagga	23	1	16	1	0	0	3	0	0	0	3	0	10	0	7	0	5	0	0	0	5	9	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:157920993G>C	uc003fbt.2	+	4	564	c.453G>C	c.(451-453)AAG>AAC	p.K151N	RSRC1_uc011bou.1_Intron|RSRC1_uc003fbu.1_Missense_Mutation_p.K151N|RSRC1_uc003fbv.2_Intron	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	151				EK -> GE (in Ref. 3; AAF64267).	nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			aaaaggagaaggataaaggga	0.368													9	25					0	0	0	0	C	157920993	C	C	157920993	3	2	194	1	0	0	0	0	1	0	0	0	13779	991	35	4	463	4	RSRC1	3	157920993	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	2717848	157920993	40101437	60	35557											
SLC2A2	6514	broad.mit.edu	37	chr3	170716928	170716928	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaattagaaagagagaacGtcgccctgccttctccacaa	13	8	7	13	2	1	3	0	0	1	3	4	4	2	3	4	0	2	0	4	0	5	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:170716928G>T	uc003fhe.1	-	9	1405	c.1096C>A	c.(1096-1098)CGT>AGT	p.R366S	SLC2A2_uc003fhf.1_Missense_Mutation_p.R193S|SLC2A2_uc011bpu.1_Missense_Mutation_p.R239S	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	366	Cytoplasmic (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			AAGAGAGAACGTCGCCCTGCC	0.398													39	107					2.54651e-27	4.04713e-27	1	0	T	170716928	T	T	170716928	3	4	194	1	0	0	0	0	1	0	0	0	14608	1145	40	3	490	3	SLC2A2	3	170716928	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	12795935	170716928	27305502	61	35558											
PIK3CA	5290	broad.mit.edu	37	chr3	178916938	178916940	+	In_Frame_Del	DEL	GAA	-	-																															ttgaaccagtaggcaaccgtGaagaaaagatcctcaatcga																										TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:178916938_178916940delGAA	uc003fjk.2	+	2	482_484	c.325_327delGAA	c.(325-327)GAAdel	p.E110del		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	110					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E109del(2)|p.G106_R108del(1)|p.E110K(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGGCAACCGTGAAGAAAAGATCC	0.34		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---								-	178916940	-	-	178916938	7	5	194	1	0	1	0	1	0	0	0	0	11968	1291	45	0	327	0	PIK3CA	3	178916938	In_Frame_Del	DEL	GAA	TCGA-CV-6935-01A-11D-1912-08	8200010	178916938	19105492	62	35559											
TECRL	253017	broad.mit.edu	37	chr4	65147243	65147243	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aaaaacatccatgtgaagggGttataatttggacttgggaa	15	11	11	4	0	0	1	0	1	0	0	1	3	1	3	1	4	1	1	1	4	6	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:65147243G>A	uc003hcv.2	-	10	976	c.867C>T	c.(865-867)AAC>AAT	p.N289N	TECRL_uc010ihi.2_RNA	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	289					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						ATGTGAAGGGGTTATAATTTG	0.328													19	7					0	0	0	0	A	65147243	A	A	65147243	2	1	194	1	0	0	0	0	0	0	0	1	15812	1252	44	4		4	TECRL	4	65147243	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08		65147243	126007033	63	35560											
NUDT9	53343	broad.mit.edu	37	chr4	88344060	88344060	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgccctcggggcgctcatGgcgggacgcctcctgggaaa	5	5	16	15	5	1	0	1	0	0	0	3	2	2	2	4	5	0	1	4	5	1	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:88344060G>A	uc003hqq.2	+	1	326	c.3G>A	c.(1-3)ATG>ATA	p.M1I	NUDT9_uc003hqr.2_Intron|NUDT9_uc010ikl.2_Missense_Mutation_p.M1I	NM_024047	NP_076952	Q9BW91	NUDT9_HUMAN	nudix-type motif 9 isoform a	1						mitochondrion	ADP-ribose diphosphatase activity				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000937)		GGGCGCTCATGGCGGGACGCC	0.672													32	52					0	0	0	0	A	88344060	A	A	88344060	3	1	194	1	0	0	0	0	1	0	0	0	10800	1348	47	4	5	4	NUDT9	4	88344060	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	23196817	88344060	102810216	64	35561											
ANKRD50	57182	broad.mit.edu	37	chr4	125600031	125600031	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataggctttgctggggaggcTtcattcccagaagagggagt	9	10	15	7	0	1	2	1	0	0	2	2	4	2	4	1	5	1	3	1	5	2	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:125600031T>G	uc003ifg.3	-	2	808	c.542A>C	c.(541-543)AAG>ACG	p.K181T	ANKRD50_uc011cgo.1_Missense_Mutation_p.K2T|ANKRD50_uc010inw.2_Missense_Mutation_p.K181T	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	181										central_nervous_system(1)	1						CTGGGGAGGCTTCATTCCCAG	0.398													3	99					0	0	0	0	G	125600031	G	G	125600031	3	3	194	1	0	0	0	0	1	0	0	0	677	1609	56	5	3755	5	ANKRD50	4	125600031	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	37255971	125600031	65554245	65	35562											
PCDH10	57575	broad.mit.edu	37	chr4	134072226	134072226	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgccgcgcactggcagactgGaggtaagcggcgagttggac	8	5	17	11	5	0	1	0	0	0	1	0	4	0	3	1	5	1	4	1	5	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:134072226G>C	uc003iha.2	+	1	1757	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.E311Q	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	311	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TGGCAGACTGGAGGTAAGCGG	0.632													37	23					0	0	0	0	C	134072226	C	C	134072226	3	2	194	1	0	0	0	0	1	0	0	0	11561	1175	41	2	933	2	PCDH10	4	134072226	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	8472195	134072226	57082050	66	35563											
NPY5R	4889	broad.mit.edu	37	chr4	164272687	164272687	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catgatgtcctgttgtcttaAtccaattctatatgggtttc	8	18	7	8	0	2	1	0	1	2	0	5	1	4	1	2	1	0	2	2	1	4	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:164272687A>G	uc003iqn.2	+	4	1444	c.1262A>G	c.(1261-1263)AAT>AGT	p.N421S		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	421	Helical; Name=7; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				TGTTGTCTTAATCCAATTCTA	0.328													45	20					0	0	0	0	G	164272687	G	G	164272687	3	3	194	1	0	0	0	0	1	0	0	0	10664	101	4	5	1264	5	NPY5R	4	164272687	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	30200461	164272687	26881589	67	35564											
CEP72	55722	broad.mit.edu	37	chr5	637653	637653	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccatggataccgaggactCggcctcttctcagaagttgg	8	10	11	12	2	2	1	1	0	2	1	5	4	3	3	3	4	1	1	3	4	2	3	rs143077618		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:637653C>T	uc003jbf.2	+	7	998	c.926C>T	c.(925-927)TCG>TTG	p.S309L	CEP72_uc011clz.1_RNA	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	309					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			ACCGAGGACTCGGCCTCTTCT	0.527													28	50					0	0	0	0	T	637653	T	T	637653	3	4	194	1	0	0	0	0	1	0	0	0	3275	893	31	1	952	1	CEP72	5	637653	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08		637653	180277607	68	35565											
DNAH5	1767	broad.mit.edu	37	chr5	13719184	13719184	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atgaaatcaagtcccagatgGcagttctgcagaagtgccca	13	8	10	10	0	2	3	1	1	1	2	3	3	3	3	2	1	2	3	2	1	3	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:13719184G>T	uc003jfd.2	-	72	12348	c.12306C>A	c.(12304-12306)TGC>TGA	p.C4102*	DNAH5_uc003jfc.2_Nonsense_Mutation_p.C270*	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4102	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GTCCCAGATGGCAGTTCTGCA	0.418									Kartagener_syndrome				22	29					1.10513e-12	1.52491e-12	1	0	T	13719184	T	T	13719184	4	4	194	1	0	0	0	0	0	1	0	0	4626	1195	42	4	1600	4	DNAH5	5	13719184	Nonsense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	13081531	13719184	167196076	69	35566											
FBXL7	23194	broad.mit.edu	37	chr5	15616151	15616151	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtacagatcacacgcccactAaagcccagaagaatgtggct	14	6	9	12	1	1	3	1	0	0	3	1	3	1	3	2	1	2	2	2	1	5	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:15616151A>G	uc003jfn.1	+	2	578	c.97A>G	c.(97-99)AAA>GAA	p.K33E		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	33					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CACGCCCACTAAAGCCCAGAA	0.453													10	25					0	0	0	0	G	15616151	G	G	15616151	3	3	194	1	0	0	0	0	1	0	0	0	5756	363	13	5	103	5	FBXL7	5	15616151	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	1896967	15616151	165299109	70	35567											
CDH9	1007	broad.mit.edu	37	chr5	26885803	26885803	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaaggatcagggcttctgcgGtgcaggattgcatgtttcct	8	12	13	8	1	2	0	1	0	1	0	3	2	3	2	1	4	3	4	1	4	1	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:26885803G>T	uc003jgs.1	-	11	1971	c.1802C>A	c.(1801-1803)ACC>AAC	p.T601N	CDH9_uc011cnv.1_Missense_Mutation_p.T194N	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	601	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GGCTTCTGCGGTGCAGGATTG	0.488													6	20					5.9392e-07	7.5244e-07	1	0	T	26885803	T	T	26885803	3	4	194	1	0	0	0	0	1	0	0	0	3132	1261	44	4	575	4	CDH9	5	26885803	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	11269652	26885803	154029457	71	35568											
DAB2	1601	broad.mit.edu	37	chr5	39376143	39376143	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctttaaagaaagggttctCaaatgcattgtcagtagatt	14	14	8	5	0	3	2	2	0	2	2	4	2	3	2	0	1	1	3	0	1	5	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:39376143C>G	uc003jlx.2	-	13	2734	c.2203G>C	c.(2203-2205)GAG>CAG	p.E735Q	DAB2_uc003jlw.2_Missense_Mutation_p.E714Q	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	735	Required for interaction with MYO6 (By similarity).				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			AAAGGGTTCTCAAATGCATTG	0.418													19	36					0	0	0	0	G	39376143	G	G	39376143	3	3	194	1	0	0	0	0	1	0	0	0	4235	835	29	2	117	2	DAB2	5	39376143	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	12490340	39376143	141539117	72	35569											
MAST4	375449	broad.mit.edu	37	chr5	66429471	66429471	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctagagagttcctggataaAcaggtaagcttgggtgccat	11	10	13	7	0	0	1	0	0	0	1	1	3	1	2	2	3	3	4	2	3	4	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:66429471A>G	uc003jut.1	+	16	1724	c.1656A>G	c.(1654-1656)AAA>AAG	p.K552K	MAST4_uc003juu.1_Silent_p.K562K|MAST4_uc011cra.1_Silent_p.K535K|MAST4_uc003juv.2_Silent_p.K547K|MAST4_uc003juw.2_Silent_p.K547K	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	744	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TCCTGGATAAACAGGTAAGCT	0.408													21	37					0	0	0	0	G	66429471	G	G	66429471	2	3	194	1	0	0	0	0	0	0	0	1	9380	40	2	5		5	MAST4	5	66429471	Silent	SNP	A	TCGA-CV-6935-01A-11D-1912-08	27053328	66429471	114485789	73	35570											
GIN1	54826	broad.mit.edu	37	chr5	102423676	102423676	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttcaagagaactatgatCgtctatcaatggagagattt	13	14	8	6	1	3	3	2	1	1	2	4	6	3	4	0	1	1	0	0	1	5	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:102423676C>A	uc003koa.1	-	8	1577	c.1495G>T	c.(1495-1497)GAT>TAT	p.D499Y	GIN1_uc003kob.1_Missense_Mutation_p.D352Y|GIN1_uc003koc.1_3'UTR	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	499					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		GAACTATGATCGTCTATCAAT	0.318													33	53					3.80469e-20	5.81318e-20	1	0	A	102423676	A	A	102423676	3	1	194	1	0	0	0	0	1	0	0	0	6423	884	31	3	77	3	GIN1	5	102423676	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	35994205	102423676	78491584	74	35571											
APC	324	broad.mit.edu	37	chr5	112151205	112151205	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttttagggttcaactacacGaatggaccatgaaacagcca	14	10	8	9	1	1	1	1	1	0	0	1	3	1	2	2	2	4	1	2	2	5	5	rs149154604		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:112151205G>A	uc010jby.2	+	9	1228	c.848G>A	c.(847-849)CGA>CAA	p.R283Q	APC_uc011cvt.1_Missense_Mutation_p.R265Q|APC_uc003kpz.3_Missense_Mutation_p.R283Q|APC_uc003kpy.3_Missense_Mutation_p.R283Q|APC_uc010jbz.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	283	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.R283*(7)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TCAACTACACGAATGGACCAT	0.383		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			17	31					0	0	0	0	A	112151205	A	A	112151205	3	1	194	1	0	0	0	0	1	0	0	0	763	1058	37	1	878	1	APC	5	112151205	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	9727529	112151205	68764055	75	35572											
KCNN2	3781	broad.mit.edu	37	chr5	113831815	113831815	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttacaatgctgagcggtcccGgtcctcgtccaggaggcggc	6	8	14	13	4	0	1	0	1	0	0	4	2	3	2	3	5	3	1	3	5	2	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:113831815G>T	uc003kqo.2	+	8	2133	c.1676G>T	c.(1675-1677)CGG>CTG	p.R559L	KCNN2_uc003kqp.2_Missense_Mutation_p.R211L|KCNN2_uc010jcg.2_RNA|uc003kqr.1_RNA	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	559						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		GAGCGGTCCCGGTCCTCGTCC	0.512													31	74					2.08457e-15	2.98035e-15	1	0	T	113831815	T	T	113831815	3	4	194	1	0	0	0	0	1	0	0	0	8118	1116	39	3	1706	3	KCNN2	5	113831815	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	1680610	113831815	67083445	76	35573											
PCDHB15	56121	broad.mit.edu	37	chr5	140627413	140627413	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtacgaggtgtgtctgaCgggaggctctgaaagtaatg	10	9	15	7	2	2	2	0	2	2	0	2	4	2	3	1	3	1	3	1	3	3	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:140627413C>A	uc003lje.2	+	1	2267	c.2267C>A	c.(2266-2268)ACG>AAG	p.T756K		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	756	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGTGTCTGACGGGAGGCTCT	0.517													71	120					4.98182e-18	7.42062e-18	1	0	A	140627413	A	A	140627413	3	1	194	1	0	0	0	0	1	0	0	0	11594	536	19	3	2269	3	PCDHB15	5	140627413	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	26795598	140627413	40287847	77	35574											
PCDHGA2	56113	broad.mit.edu	37	chr5	140718609	140718609	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttccttttggcgaccctgtGggaggccagggccgggcaga	5	8	16	12	2	0	1	0	0	0	1	1	3	1	2	4	5	0	1	4	5	0	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:140718609G>T	uc003ljk.1	+	1	256	c.71G>T	c.(70-72)TGG>TTG	p.W24L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.W24L	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	24					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGACCCTGTGGGAGGCCAGG	0.577											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	42					1.67942e-08	2.1662e-08	1	0	T	140718609	T	T	140718609	3	4	194	1	0	0	0	0	1	0	0	0	11608	1357	47	4	73	4	PCDHGA2	5	140718609	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	91196	140718609	40196651	78	35575											
PCDHGB3	56102	broad.mit.edu	37	chr5	140751081	140751081	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgatcaaaacacatgatCtagattctggatttaatgga	14	12	7	8	0	3	3	1	2	2	1	3	5	3	5	1	2	1	0	1	2	4	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:140751081C>A	uc003ljw.1	+	1	1120	c.1120C>A	c.(1120-1122)CTA>ATA	p.L374I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.L374I|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	374	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACACATGATCTAGATTCTGG	0.423													7	24					0.00198382	0.00238594	1	0	A	140751081	A	A	140751081	3	1	194	1	0	0	0	0	1	0	0	0	11618	912	32	2	1122	2	PCDHGB3	5	140751081	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	32472	140751081	40164179	79	35576											
PCDHGA9	56107	broad.mit.edu	37	chr5	140784798	140784798	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctcaggagttctccctcaCcgctgactcaaggaagagtc	9	10	9	13	1	4	2	3	1	2	1	7	4	4	4	2	2	0	2	2	2	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:140784798C>A	uc003lkh.1	+	1	2279	c.2279C>A	c.(2278-2280)ACC>AAC	p.T760N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.T760N|PCDHGB6_uc003lki.1_5'Flank|PCDHGB6_uc003lkj.1_5'Flank	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	760	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTCCCTCACCGCTGACTCA	0.537													44	83					1.48734e-19	2.26279e-19	1	0	A	140784798	A	A	140784798	3	1	194	1	0	0	0	0	1	0	0	0	11615	507	18	4	2281	4	PCDHGA9	5	140784798	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	33717	140784798	40130462	80	35577											
PCDHGB7	56099	broad.mit.edu	37	chr5	140797510	140797510	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgcctttgttctaccccacGctgtgtgagccgatccgcta	5	12	9	15	3	1	1	0	1	1	0	2	2	2	1	5	0	3	3	5	0	2	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:140797510G>T	uc003lkn.1	+	1	229	c.84G>T	c.(82-84)ACG>ACT	p.T28T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Silent_p.T28T	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	28					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTACCCCACGCTGTGTGAGC	0.527											OREG0016863	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	23					5.50884e-06	6.85715e-06	1	0	T	140797510	T	T	140797510	2	4	194	1	0	0	0	0	0	0	0	1	11622	1074	38	3		3	PCDHGB7	5	140797510	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	12712	140797510	40117750	81	35578											
PANK3	79646	broad.mit.edu	37	chr5	168006280	168006280	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggtttcttggcatctttGatcttcatggcgtcggcccg	4	14	12	11	3	4	1	1	1	3	0	5	1	4	1	1	4	0	2	1	4	0	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:168006280G>A	uc003lzz.1	-	1	309	c.9C>T	c.(7-9)ATC>ATT	p.I3I		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	3					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		TGGCATCTTTGATCTTCATGG	0.706													6	9					0	0	0	0	A	168006280	A	A	168006280	2	1	194	1	0	0	0	0	0	0	0	1	11472	1280	45	2		2	PANK3	5	168006280	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	27208770	168006280	12908980	82	35579											
STK10	6793	broad.mit.edu	37	chr5	171488156	171488156	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccacctcgaaggagctcCtgcttcttcatgaggcactc	7	9	8	17	1	2	1	1	1	1	0	5	3	3	2	4	2	2	3	4	2	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:171488156C>A	uc003mbo.1	-	14	2499	c.2199G>T	c.(2197-2199)CAG>CAT	p.Q733H		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	733	Potential.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAAGGAGCTCCTGCTTCTTCA	0.617													71	140					9.12251e-31	1.47619e-30	1	0	A	171488156	A	A	171488156	3	1	194	1	0	0	0	0	1	0	0	0	15352	680	24	4	731	4	STK10	5	171488156	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	3481876	171488156	9427104	83	35580											
ABT1	29777	broad.mit.edu	37	chr6	26597372	26597372	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtacctgggccatatcccGccgcgcttccggcccctgca	4	8	11	18	4	0	0	0	0	0	0	2	0	2	0	7	2	2	3	7	2	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:26597372G>T	uc003nii.2	+	1	193	c.162G>T	c.(160-162)CCG>CCT	p.P54P		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	54	RRM.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1						GCCATATCCCGCCGCGCTTCC	0.612													16	28					2.32078e-09	3.04871e-09	1	0	T	26597372	T	T	26597372	2	4	194	1	0	0	0	0	0	0	0	1	101	1074	38	3		3	ABT1	6	26597372	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08		26597372	144517695	84	35581											
TRIM39	56658	broad.mit.edu	37	chr6	30297275	30297275	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccgctggtgggaggacctaGagagggacttcccttgtcct	6	9	14	12	1	0	1	0	0	0	1	2	5	2	4	4	4	0	1	4	4	1	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:30297275G>A	uc010jrz.2	+	3	493	c.181G>A	c.(181-183)GAG>AAG	p.E61K	HCG18_uc003npx.2_5'Flank|HCG18_uc003npy.2_5'Flank|TRIM39_uc003npz.2_Missense_Mutation_p.E61K|TRIM39_uc003nqb.2_Missense_Mutation_p.E61K|TRIM39_uc003nqc.2_Missense_Mutation_p.E61K|TRIM39_uc010jsa.1_Missense_Mutation_p.E61K	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	61	RING-type.				apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						GGAGGACCTAGAGAGGGACTT	0.542													48	83					0	0	0	0	A	30297275	A	A	30297275	3	1	194	1	0	0	0	0	1	0	0	0	16580	943	33	2	183	2	TRIM39	6	30297275	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	3699903	30297275	140817792	85	35582											
PBX2	5089	broad.mit.edu	37	chr6	32154610	32154610	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggaagcagaataggaatCtccgttgagcccaggcatcc	11	7	12	11	1	1	2	0	1	1	1	3	4	2	4	3	3	2	3	3	3	4	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:32154610C>T	uc003oav.1	-	7	1364	c.1093G>A	c.(1093-1095)GAT>AAT	p.D365N	AGER_uc003oar.2_5'Flank|AGER_uc011dpm.1_5'Flank|AGER_uc011dpn.1_5'Flank|AGER_uc003oal.1_5'Flank|AGER_uc010jtv.1_5'Flank|AGER_uc011dpo.1_5'Flank|AGER_uc003oam.1_5'Flank|AGER_uc003oan.1_5'Flank|AGER_uc003oap.1_5'Flank|AGER_uc003oat.1_5'Flank|AGER_uc003oao.1_5'Flank|AGER_uc003oaq.1_5'Flank|AGER_uc010jtw.1_5'Flank|AGER_uc003oas.1_5'Flank|AGER_uc003oau.1_5'Flank|AGER_uc011dpp.1_5'Flank|AGER_uc011dpq.1_5'Flank|AGER_uc011dpr.1_5'Flank|AGER_uc011dps.1_5'Flank	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	365							transcription factor binding			ovary(1)	1						GAATAGGAATCTCCGTTGAGC	0.512													30	55					0	0	0	0	T	32154610	T	T	32154610	3	4	194	1	0	0	0	0	1	0	0	0	11547	913	32	2	211	2	PBX2	6	32154610	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	1857335	32154610	138960457	86	35583											
APOBEC2	10930	broad.mit.edu	37	chr6	41029194	41029194	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggccaagtgcaggcatctCggggatacctagaggatgag	10	6	17	8	1	1	2	0	1	1	1	2	4	1	4	2	6	2	2	2	6	3	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:41029194C>A	uc003opl.2	+	2	406	c.259C>A	c.(259-261)CGG>AGG	p.R87R	UNC5CL_uc010jxe.1_Intron|APOBEC2_uc010jxf.2_Intron	NM_006789	NP_006780	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	87					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCAGGCATCTCGGGGATACCT	0.567													36	82					4.34311e-12	5.92393e-12	1	0	A	41029194	A	A	41029194	2	1	194	1	0	0	0	0	0	0	0	1	788	875	31	3		3	APOBEC2	6	41029194	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	8874584	41029194	130085873	87	35584											
HCRTR2	3062	broad.mit.edu	37	chr6	55113511	55113511	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtcaatctttctctggctGatgtgctcgtgaccatcacc	7	14	8	12	1	4	2	2	2	2	0	6	2	4	2	2	1	1	2	2	1	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:55113511G>T	uc003pcl.2	+	2	613	c.298G>T	c.(298-300)GAT>TAT	p.D100Y	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.D35Y	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	100	Helical; Name=2; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTCTCTGGCTGATGTGCTCGT	0.453													56	102					6.4308e-24	1.00411e-23	1	0	T	55113511	T	T	55113511	3	4	194	1	0	0	0	0	1	0	0	0	7041	1290	45	2	304	2	HCRTR2	6	55113511	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	14084317	55113511	116001556	88	35585											
COL19A1	1310	broad.mit.edu	37	chr6	70856592	70856592	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacctggtccacgtgggccAaaggtatacaaatattatag	13	9	10	9	1	0	0	0	0	0	0	1	0	1	0	3	3	1	2	3	3	7	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:70856592A>T	uc003pfc.1	+	26	1929	c.1812A>T	c.(1810-1812)CCA>CCT	p.P604P	COL19A1_uc010kam.1_Silent_p.P500P	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	604	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						CACGTGGGCCAAAGGTATACA	0.323													5	11					0	0	0	0	T	70856592	T	T	70856592	2	4	194	1	0	0	0	0	0	0	0	1	3691	117	5	5		5	COL19A1	6	70856592	Silent	SNP	A	TCGA-CV-6935-01A-11D-1912-08	15743081	70856592	100258475	89	35586											
SPACA1	81833	broad.mit.edu	37	chr6	88763681	88763681	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtttcaaataggaatgtcGtcaaagaagtagaattcgga	16	11	10	4	2	2	2	2	0	0	2	4	4	2	4	0	2	0	2	0	2	8	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:88763681G>C	uc003pmn.2	+	2	343	c.226G>C	c.(226-228)GTC>CTC	p.V76L		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1 precursor	76	Extracellular (Potential).					integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		TAGGAATGTCGTCAAAGAAGT	0.348													8	20					0	0	0	0	C	88763681	C	C	88763681	3	2	194	1	0	0	0	0	1	0	0	0	15036	1145	40	3	232	3	SPACA1	6	88763681	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	17907089	88763681	82351386	90	35587											
ROS1	6098	broad.mit.edu	37	chr6	117683782	117683782	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atacctggaaggcaataaagCatctgggactcatgccttca	13	9	9	10	0	3	0	2	0	1	0	3	2	3	2	2	3	3	2	2	3	5	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:117683782C>A	uc003pxp.1	-	21	3564	c.3365G>T	c.(3364-3366)TGC>TTC	p.C1122F	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1122	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GGCAATAAAGCATCTGGGACT	0.408			T	GOPC|ROS1	glioblastoma|NSCLC								12	26					0.00010058	0.000123046	1	0	A	117683782	A	A	117683782	3	1	194	1	0	0	0	0	1	0	0	0	13596	710	25	4	3770	4	ROS1	6	117683782	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	28920101	117683782	53431285	91	35588											
ROS1	6098	broad.mit.edu	37	chr6	117709005	117709005	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggcctctttggagaacttGctctcacagaaaccttgtat	9	13	8	11	0	2	2	1	0	2	2	3	3	2	2	2	2	3	2	2	2	3	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:117709005G>A	uc003pxp.1	-	13	2151	c.1952C>T	c.(1951-1953)GCA>GTA	p.A651V	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	651	Fibronectin type-III 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGGAGAACTTGCTCTCACAGA	0.488			T	GOPC|ROS1	glioblastoma|NSCLC								50	70					0	0	0	0	A	117709005	A	A	117709005	3	1	194	1	0	0	0	0	1	0	0	0	13596	1319	46	4	5215	4	ROS1	6	117709005	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	25223	117709005	53406062	92	35589											
THEMIS	387357	broad.mit.edu	37	chr6	128222065	128222065	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtggacgaattcttccaGtgataatgccattgctatgc	10	12	11	8	1	1	1	0	1	1	0	2	4	2	3	2	2	3	1	2	2	3	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:128222065G>T	uc003qbi.2	-	2	332	c.13C>A	c.(13-15)CTG>ATG	p.L5M	THEMIS_uc011ebt.1_Missense_Mutation_p.L5M|THEMIS_uc010kfb.2_Intron	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	5	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						AATTCTTCCAGTGATAATGCC	0.498													51	69					9.57592e-29	1.5356e-28	1	0	T	128222065	T	T	128222065	3	4	194	1	0	0	0	0	1	0	0	0	15926	1020	36	4	2057	4	THEMIS	6	128222065	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	10513060	128222065	42893002	93	35590											
ENPP3	5169	broad.mit.edu	37	chr6	132061454	132061454	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agccacacaccggaaaactgCcctgggtggctggatgtcct	9	7	12	13	1	0	0	0	0	0	0	1	2	1	2	4	4	3	1	4	4	2	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:132061454C>T	uc003qcu.3	+	25	2738	c.2391C>T	c.(2389-2391)TGC>TGT	p.C797C	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Silent_p.C797C	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	797	Extracellular (Potential).|Nuclease.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CGGAAAACTGCCCTGGGTGGC	0.512													31	50					0	0	0	0	T	132061454	T	T	132061454	2	4	194	1	0	0	0	0	0	0	0	1	5155	747	26	4		4	ENPP3	6	132061454	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	3839389	132061454	39053613	94	35591											
KIAA1244	57221	broad.mit.edu	37	chr6	138601217	138601217	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgaggagctctaccatcagGtgctcgacaggaacatgctt	10	10	11	10	1	2	1	1	1	1	0	3	4	2	3	1	3	5	3	1	3	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:138601217G>A	uc003qhu.2	+	14	2377	c.2377G>A	c.(2377-2379)GTG>ATG	p.V793M		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	793	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CTACCATCAGGTGCTCGACAG	0.552													28	29					0	0	0	0	A	138601217	A	A	138601217	3	1	194	1	0	0	0	0	1	0	0	0	8256	1261	44	4	2431	4	KIAA1244	6	138601217	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	6539763	138601217	32513850	95	35592											
PDE10A	10846	broad.mit.edu	37	chr6	165957010	165957010	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatacaaattcatctaatacCtgggggtgaagagaaagata	17	9	10	5	0	2	3	1	1	1	2	2	5	2	3	1	2	2	0	1	2	7	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:165957010C>A	uc003qun.2	-	3	325	c.84G>T	c.(82-84)CAG>CAT	p.Q28H	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Translation_Start_Site|PDE10A_uc003quo.2_Missense_Mutation_p.Q38H	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	28					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CATCTAATACCTGGGGGTGAA	0.358													18	28					5.03518e-11	6.76425e-11	1	0	A	165957010	A	A	165957010	3	1	194	1	0	0	0	0	1	0	0	0	11684	680	24	4	2339	4	PDE10A	6	165957010	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	27355793	165957010	5158057	96	35593											
STK31	56164	broad.mit.edu	37	chr7	23827673	23827673	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgacataattcatggatcActtcatcagaacaatgtatt	14	13	6	8	0	4	2	4	1	0	1	4	3	4	3	0	1	1	2	0	1	4	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:23827673A>G	uc003sws.3	+	21	2629	c.2562A>G	c.(2560-2562)TCA>TCG	p.S854S	STK31_uc003swt.3_Silent_p.S831S|STK31_uc011jze.1_Silent_p.S854S|STK31_uc010kuq.2_Silent_p.S831S|STK31_uc003swv.1_Silent_p.S20S	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	854	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TTCATGGATCACTTCATCAGA	0.353													33	93					0	0	0	0	G	23827673	G	G	23827673	2	3	194	1	0	0	0	0	0	0	0	1	15362	146	6	5		5	STK31	7	23827673	Silent	SNP	A	TCGA-CV-6935-01A-11D-1912-08		23827673	135310990	97	35594											
STK31	56164	broad.mit.edu	37	chr7	23871841	23871841	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttttaaatgctgaatgtttCttgatgccaaaggagcaatc	12	14	9	6	0	1	2	0	2	1	0	2	3	1	3	1	1	3	4	1	1	5	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:23871841C>T	uc003sws.3	+	24	2983	c.2916C>T	c.(2914-2916)TTC>TTT	p.F972F	STK31_uc003swt.3_Silent_p.F949F|STK31_uc011jze.1_Silent_p.F949F|STK31_uc010kuq.2_Silent_p.F949F|STK31_uc003swv.1_Silent_p.F138F	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	972	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CTGAATGTTTCTTGATGCCAA	0.353													68	60					0	0	0	0	T	23871841	T	T	23871841	2	4	194	1	0	0	0	0	0	0	0	1	15362	912	32	2		2	STK31	7	23871841	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	44168	23871841	135266822	98	35595											
BBS9	27241	broad.mit.edu	37	chr7	33397536	33397536	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcctaccaggtcagccttCaaaaactgcaagccacaaaa	15	7	6	13	0	2	0	2	0	0	0	2	0	2	0	4	1	6	1	4	1	6	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:33397536C>A	uc003tdn.1	+	16	2135	c.1622C>A	c.(1621-1623)TCA>TAA	p.S541*	BBS9_uc003tdo.1_Nonsense_Mutation_p.S506*|BBS9_uc003tdp.1_Nonsense_Mutation_p.S536*|BBS9_uc003tdq.1_Nonsense_Mutation_p.S501*|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Nonsense_Mutation_p.S65*|BBS9_uc003tds.1_5'UTR|BBS9_uc011kao.1_Nonsense_Mutation_p.S419*	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	541					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GGTCAGCCTTCAAAAACTGCA	0.378									Bardet-Biedl_syndrome				8	107					0.000978159	0.00118042	1	0	A	33397536	A	A	33397536	4	1	194	1	0	0	0	0	0	1	0	0	1344	838	29	2	1680	2	BBS9	7	33397536	Nonsense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	9525695	33397536	125741127	99	35596											
INHBA	3624	broad.mit.edu	37	chr7	41739824	41739824	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccaccatctctggctgaGagttgggtacatcctttggg	6	12	11	12	0	1	1	0	1	1	1	4	2	3	1	4	3	1	3	4	3	1	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:41739824G>T	uc003thq.2	-	1	384	c.149C>A	c.(148-150)TCT>TAT	p.S50Y	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Missense_Mutation_p.S50Y|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	50					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						CTCTGGCTGAGAGTTGGGTAC	0.612										TSP Lung(11;0.080)			187	256					7.59282e-81	1.28716e-80	1	0	T	41739824	T	T	41739824	3	4	194	1	0	0	0	0	1	0	0	0	7780	942	33	2	1139	2	INHBA	7	41739824	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	8342288	41739824	117398839	100	35597											
ZNF716	441234	broad.mit.edu	37	chr7	57529071	57529071	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctacacatgtgaagaatgtGgcaaagcctttagccgctct	11	10	9	11	1	1	2	0	1	1	1	1	2	1	2	3	1	3	2	3	1	5	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:57529071G>T	uc011kdi.1	+	4	1016	c.904G>T	c.(904-906)GGC>TGC	p.G302C		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						TGAAGAATGTGGCAAAGCCTT	0.418													8	16					0.00307968	0.00367908	1	0	T	57529071	T	T	57529071	3	4	194	1	0	0	0	0	1	0	0	0	18186	1348	47	4	918	4	ZNF716	7	57529071	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	15789247	57529071	101609592	101	35598											
ZNF117	51351	broad.mit.edu	37	chr7	64452342	64452342	+	5'Flank	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttaactctcctactgggtCtgtaaaggcctttccccagc	8	12	8	13	0	2	0	0	0	2	0	4	0	3	0	4	2	3	2	4	2	4	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:64452342C>A	uc003ttr.2	-						ZNF117_uc011kdr.1_Missense_Mutation_p.D352Y	NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				cctactgggtctgtaaaggcc	0													13	31					3.03607e-14	4.30614e-14	1	0	A	64452342	A	A	64452342	1	1	194	0	1	0	0	0	0	0	0	0	17784	913	32	2		2	ZNF117	7	64452342	5'Flank	SNP	C	TCGA-CV-6935-01A-11D-1912-08	6923271	64452342	94686321	102	35599											
WBSCR17	64409	broad.mit.edu	37	chr7	71142291	71142291	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccatggctggggaccacaGgtaggagctcgtctctgacc	7	8	14	12	1	1	1	0	1	1	0	3	3	1	3	3	5	2	3	3	5	1	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:71142291G>T	uc003tvy.2	+	9	1500	c.1500G>T	c.(1498-1500)CAG>CAT	p.Q500H	WBSCR17_uc003tvz.2_Missense_Mutation_p.Q199H	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	500	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGGGACCACAGGTAGGAGCTC	0.537													61	111					1.03172e-35	1.70834e-35	1	0	T	71142291	T	T	71142291	3	4	194	1	0	0	0	0	1	0	0	0	17332	1014	35	4	1534	4	WBSCR17	7	71142291	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	6689949	71142291	87996372	103	35600											
PCLO	27445	broad.mit.edu	37	chr7	82582174	82582174	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tagagcaagaggctctggagGaattgttatggaaatgctgc	12	10	14	5	0	1	2	0	0	1	2	1	5	1	5	0	4	3	4	0	4	5	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:82582174G>T	uc003uhx.2	-	5	8384	c.8095C>A	c.(8095-8097)CCT>ACT	p.P2699T	PCLO_uc003uhv.2_Missense_Mutation_p.P2699T|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2630					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGCTCTGGAGGAATTGTTATG	0.403													18	47					3.32936e-07	4.23304e-07	1	0	T	82582174	T	T	82582174	3	4	194	1	0	0	0	0	1	0	0	0	11637	1174	41	2	7434	2	PCLO	7	82582174	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	11439883	82582174	76556489	104	35601											
ZNF804B	219578	broad.mit.edu	37	chr7	88847532	88847532	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaggcaaacttttactgtGaattatgtgacaagcagtat	15	13	8	5	0	0	2	0	2	0	0	0	2	0	2	0	1	3	3	0	1	8	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:88847532G>T	uc011khi.1	+	2	710	c.172G>T	c.(172-174)GAA>TAA	p.E58*		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	58	C2H2-type.					intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CTTTTACTGTGAATTATGTGA	0.368										HNSCC(36;0.09)			26	29					1.1804e-14	1.68088e-14	1	0	T	88847532	T	T	88847532	4	4	194	1	0	0	0	0	0	1	0	0	18238	1291	45	2	178	2	ZNF804B	7	88847532	Nonsense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	6265358	88847532	70291131	105	35602											
CCDC132	55610	broad.mit.edu	37	chr7	92887685	92887685	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagcaaagaacagatgtacGgttaagtgaaatgctggagg	15	8	13	5	1	1	3	1	1	0	2	1	4	1	4	0	3	4	4	0	3	5	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:92887685G>T	uc003umo.2	+	8	685	c.557G>T	c.(556-558)CGG>CTG	p.R186L	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.R156L|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Missense_Mutation_p.R186L	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	186											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ACAGATGTACGGTTAAGTGAA	0.299													20	52					3.5997e-14	5.08529e-14	1	0	T	92887685	T	T	92887685	3	4	194	1	0	0	0	0	1	0	0	0	2779	1116	39	3	587	3	CCDC132	7	92887685	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	4040153	92887685	66250978	106	35603											
PPP1R9A	55607	broad.mit.edu	37	chr7	94791279	94791279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaaacaccaagggcaacGtcaggtaaatacgtgccttc	14	7	9	11	2	2	1	2	0	0	1	3	1	2	1	2	2	4	2	2	2	6	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:94791279G>A	uc003unp.2	+	5	2032	c.1750G>A	c.(1750-1752)GTC>ATC	p.V584I	PPP1R9A_uc010lfj.2_Missense_Mutation_p.V584I|PPP1R9A_uc011kif.1_Missense_Mutation_p.V584I|PPP1R9A_uc003unq.2_Missense_Mutation_p.V584I|PPP1R9A_uc011kig.1_Missense_Mutation_p.V584I	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	584	PDZ.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CAAGGGCAACGTCAGGTAAAT	0.363										HNSCC(28;0.073)			5	3					0	0	0	0	A	94791279	A	A	94791279	3	1	194	1	0	0	0	0	1	0	0	0	12438	1145	40	1	1764	1	PPP1R9A	7	94791279	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	1903594	94791279	64347384	107	35604											
TRRAP	8295	broad.mit.edu	37	chr7	98581764	98581764	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcagcatgatcccagttcaaAtaacgctatgcttggggttc	10	12	9	10	1	2	1	2	1	0	0	4	1	3	1	1	2	3	5	1	2	3	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:98581764A>G	uc003upp.2	+	60	9292	c.9083A>G	c.(9082-9084)AAT>AGT	p.N3028S	TRRAP_uc011kis.1_Missense_Mutation_p.N2999S|TRRAP_uc003upr.2_Missense_Mutation_p.N2716S	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3028	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCCAGTTCAAATAACGCTATG	0.448													43	62					0	0	0	0	G	98581764	G	G	98581764	3	3	194	1	0	0	0	0	1	0	0	0	16668	101	4	5	9226	5	TRRAP	7	98581764	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	3790485	98581764	60556899	108	35605											
MET	4233	broad.mit.edu	37	chr7	116339752	116339752	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caataccataaattcttcttAtttcccagatcatccattgc	12	15	2	12	0	3	1	1	0	2	1	5	1	5	1	3	0	2	0	3	0	5	7			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:116339752A>G	uc003vij.2	+	2	801	c.614A>G	c.(613-615)TAT>TGT	p.Y205C	MET_uc010lkh.2_Missense_Mutation_p.Y205C|MET_uc011knc.1_Missense_Mutation_p.Y205C|MET_uc011knd.1_Missense_Mutation_p.Y205C|MET_uc011kne.1_Missense_Mutation_p.Y205C|MET_uc011knf.1_Missense_Mutation_p.Y205C|MET_uc011kng.1_Missense_Mutation_p.Y205C|MET_uc011knh.1_Missense_Mutation_p.Y205C|MET_uc011kni.1_Missense_Mutation_p.Y205C|MET_uc003vii.1_Missense_Mutation_p.Y224C|MET_uc010lkg.2_Missense_Mutation_p.Y205C|MET_uc011kmz.1_Missense_Mutation_p.Y205C|MET_uc011kna.1_Missense_Mutation_p.Y205C|MET_uc011knb.1_Missense_Mutation_p.Y205C	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	205	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AATTCTTCTTATTTCCCAGAT	0.418			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				67	89					0	0	0	0	G	116339752	G	G	116339752	3	3	194	1	0	0	0	0	1	0	0	0	9538	449	16	5	616	5	MET	7	116339752	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	17757988	116339752	42798911	109	35606											
GRM8	2918	broad.mit.edu	37	chr7	126544151	126544151	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagaaaatgcccactttggTttagtttttttgctgcttcc	8	17	8	8	0	0	1	0	0	0	1	1	2	1	1	2	1	3	4	2	1	3	7			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:126544151T>C	uc003vlr.2	-	4	1204	c.893A>G	c.(892-894)AAC>AGC	p.N298S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.N298S|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.N19S	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	298	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCCACTTTGGTTTAGTTTTTT	0.368										HNSCC(24;0.065)			42	60					0	0	0	0	C	126544151	C	C	126544151	3	2	194	1	0	0	0	0	1	0	0	0	6842	1725	60	5	1911	5	GRM8	7	126544151	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	10204399	126544151	32594512	110	35607											
MGAM	8972	broad.mit.edu	37	chr7	141755884	141755884	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggagtgctcctgctgaacAgcaatgccatgggtaaggcc	10	8	13	10	0	0	1	0	1	0	0	1	2	1	2	3	3	5	4	3	3	3	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:141755884A>C	uc003vwy.2	+	29	3622	c.3568A>C	c.(3568-3570)AGC>CGC	p.S1190R		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1190	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTGCTGAACAGCAATGCCAT	0.512													8	3					0	0	0	0	C	141755884	C	C	141755884	3	2	194	1	0	0	0	0	1	0	0	0	9594	188	7	5	3678	5	MGAM	7	141755884	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	15211733	141755884	17382779	111	35608											
GALNTL5	168391	broad.mit.edu	37	chr7	151699803	151699803	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcttgcctccccaggggaTgttctggtgttcctggacag	4	13	13	11	0	2	0	0	0	2	0	4	2	4	2	4	4	1	3	4	4	0	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:151699803T>A	uc003wkp.2	+	6	886	c.663T>A	c.(661-663)GAT>GAA	p.D221E	GALNTL5_uc003wkq.2_5'UTR|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.D110E	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	221	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		CCCCAGGGGATGTTCTGGTGT	0.498													25	12					0	0	0	0	A	151699803	A	A	151699803	3	1	194	1	0	0	0	0	1	0	0	0	6259	1461	51	5	681	5	GALNTL5	7	151699803	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	9943919	151699803	7438860	112	35609											
MSC	9242	broad.mit.edu	37	chr8	72754902	72754902	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttccagtccgatttaagcGgtggttccacatagtctgtt	8	14	10	9	2	1	0	0	0	1	0	4	1	4	0	3	2	1	3	3	2	2	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:72754902G>T	uc003xyx.1	-	2	933	c.615C>A	c.(613-615)ACC>ACA	p.T205T	uc011lff.1_5'Flank|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	205					transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			CGATTTAAGCGGTGGTTCCAC	0.493													200	317					3.50731e-122	6.03189e-122	1	0	T	72754902	T	T	72754902	2	4	194	1	0	0	0	0	0	0	0	1	9921	1103	39	3		3	MSC	8	72754902	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08		72754902	73609120	113	35610											
PSKH2	85481	broad.mit.edu	37	chr8	87060915	87060915	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatggtccagggcctggcCagctgacatgcgatgaccag	8	6	16	11	1	0	2	0	2	0	0	1	4	1	3	4	4	2	1	4	4	0	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:87060915C>G	uc011lfy.1	-	3	934	c.934G>C	c.(934-936)GGC>CGC	p.G312R		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	312	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			AGGGCCTGGCCAGCTGACATG	0.512													36	49					0	0	0	0	G	87060915	G	G	87060915	3	3	194	1	0	0	0	0	1	0	0	0	12727	594	21	4	225	4	PSKH2	8	87060915	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	14306013	87060915	59303107	114	35611											
CDH17	1015	broad.mit.edu	37	chr8	95174380	95174380	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgatttgcacaaaacaaagGgtcttgaaatctgaaaacca	17	10	7	7	0	2	3	0	3	2	0	2	3	2	3	1	1	3	1	1	1	6	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:95174380G>T	uc003ygh.2	-	11	1418	c.1293C>A	c.(1291-1293)ACC>ACA	p.T431T	CDH17_uc011lgo.1_Silent_p.T217T|CDH17_uc011lgp.1_Silent_p.T431T	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	431	Extracellular (Potential).|Cadherin 4.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CAAAACAAAGGGTCTTGAAAT	0.313													13	30					6.72482e-11	9.00014e-11	1	0	T	95174380	T	T	95174380	2	4	194	1	0	0	0	0	0	0	0	1	3117	1219	43	4		4	CDH17	8	95174380	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	8113465	95174380	51189642	115	35612											
PGCP	10404	broad.mit.edu	37	chr8	97978226	97978226	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggtgccatggatgatggcGgtggagcctttatatcatgg	8	11	16	6	1	1	1	1	1	0	0	1	3	1	3	2	6	2	0	2	6	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:97978226G>A	uc003yhw.2	+	5	1079	c.913G>A	c.(913-915)GGT>AGT	p.G305S	PGCP_uc010mbe.2_Missense_Mutation_p.G305S	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	305					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					GGATGATGGCGGTGGAGCCTT	0.378													3	56					0	0	0	0	A	97978226	A	A	97978226	3	1	194	1	0	0	0	0	1	0	0	0	11841	1116	39	1	927	1	PGCP	8	97978226	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	2803846	97978226	48385796	116	35613											
PKHD1L1	93035	broad.mit.edu	37	chr8	110451290	110451290	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaacatgatatctatgtaGaagtcagaaactggggtttt	15	12	10	4	0	2	3	1	1	1	2	2	4	2	3	0	2	2	2	0	2	7	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:110451290G>A	uc003yne.2	+	32	4029	c.3925G>A	c.(3925-3927)GAA>AAA	p.E1309K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1309	Extracellular (Potential).|IPT/TIG 6.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TATCTATGTAGAAGTCAGAAA	0.398										HNSCC(38;0.096)			64	106					0	0	0	0	A	110451290	A	A	110451290	3	1	194	1	0	0	0	0	1	0	0	0	12027	943	33	2	4051	2	PKHD1L1	8	110451290	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	12473064	110451290	35912732	117	35614											
PKHD1L1	93035	broad.mit.edu	37	chr8	110476802	110476802	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctgttgctggtggcactCactttggcttttggtaccgg	4	15	13	9	1	1	0	1	0	0	0	1	0	1	0	1	5	3	6	1	5	1	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:110476802C>A	uc003yne.2	+	49	7845	c.7741C>A	c.(7741-7743)CAC>AAC	p.H2581N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2581	Extracellular (Potential).|PbH1 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGGTGGCACTCACTTTGGCTT	0.463										HNSCC(38;0.096)			24	35					2.21704e-12	3.04735e-12	1	0	A	110476802	A	A	110476802	3	1	194	1	0	0	0	0	1	0	0	0	12027	826	29	2	7935	2	PKHD1L1	8	110476802	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	25512	110476802	35887220	118	35615											
CSMD3	114788	broad.mit.edu	37	chr8	113246662	113246662	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagcaggtactttaataaGatatatgcgtaacattaggc	15	12	9	5	1	0	2	0	1	0	1	0	2	0	2	0	2	4	3	0	2	7	8			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:113246662G>T	uc003ynu.2	-	68	10831	c.10672C>A	c.(10672-10674)CTT>ATT	p.L3558I	CSMD3_uc003yns.2_Missense_Mutation_p.L2760I|CSMD3_uc003ynt.2_Missense_Mutation_p.L3518I|CSMD3_uc011lhx.1_Missense_Mutation_p.L3389I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3558	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACTTTAATAAGATATATGCGT	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			50	95					1.4374e-25	2.26422e-25	1	0	T	113246662	T	T	113246662	3	4	194	1	0	0	0	0	1	0	0	0	3963	942	33	2	467	2	CSMD3	8	113246662	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	2769860	113246662	33117360	119	35616											
CSMD3	114788	broad.mit.edu	37	chr8	113697930	113697930	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggagaaagaactgttccCattggtgcagtaaagttaga	14	10	11	6	0	1	3	1	0	0	3	2	4	2	3	1	2	2	4	1	2	5	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:113697930C>A	uc003ynu.2	-	15	2346	c.2187G>T	c.(2185-2187)ATG>ATT	p.M729I	CSMD3_uc003yns.2_Missense_Mutation_p.M1I|CSMD3_uc003ynt.2_Missense_Mutation_p.M689I|CSMD3_uc011lhx.1_Missense_Mutation_p.M625I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	729	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GAACTGTTCCCATTGGTGCAG	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	64					1.74197e-06	2.1836e-06	1	0	A	113697930	A	A	113697930	3	1	194	1	0	0	0	0	1	0	0	0	3963	594	21	4	9164	4	CSMD3	8	113697930	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	451268	113697930	32666092	120	35617											
ZHX2	22882	broad.mit.edu	37	chr8	123965602	123965602	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctcgactcgaccagctcTccggtgcccagttaacaagt	8	10	9	14	3	2	0	0	0	2	0	5	2	2	0	3	1	3	2	3	1	2	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:123965602T>C	uc003ypk.1	+	3	2419	c.1852T>C	c.(1852-1854)TCC>CCC	p.S618P		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	618						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CGACCAGCTCTCCGGTGCCCA	0.532													25	52					0	0	0	0	C	123965602	C	C	123965602	3	2	194	1	0	0	0	0	1	0	0	0	17743	1551	54	5	1854	5	ZHX2	8	123965602	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	10267672	123965602	22398420	121	35618											
FAM135B	51059	broad.mit.edu	37	chr8	139151251	139151251	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttttttggcttagttggtaGaggaaacatttgcgcaaatc	10	15	11	5	1	0	1	0	0	0	1	1	2	0	2	0	3	2	5	0	3	4	7			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:139151251G>C	uc003yuy.2	-	18	4050	c.3879C>G	c.(3877-3879)CTC>CTG	p.L1293L	FAM135B_uc003yux.2_Silent_p.L1194L|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1293										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTAGTTGGTAGAGGAAACATT	0.438										HNSCC(54;0.14)			12	127					0	0	0	0	C	139151251	C	C	139151251	2	2	194	1	0	0	0	0	0	0	0	1	5477	929	33	2		2	FAM135B	8	139151251	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	15185649	139151251	7212771	122	35619											
FAM135B	51059	broad.mit.edu	37	chr8	139165165	139165165	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagatgtttggccagtccaaCattcatcttcaggcacacct	10	11	7	13	0	3	1	2	0	1	1	4	1	4	1	3	2	1	2	3	2	1	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:139165165C>A	uc003yuy.2	-	13	1724	c.1553G>T	c.(1552-1554)TGT>TTT	p.C518F	FAM135B_uc003yux.2_Missense_Mutation_p.C419F|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.C80F|FAM135B_uc003yvb.2_Missense_Mutation_p.C80F	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	518										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCCAGTCCAACATTCATCTTC	0.463										HNSCC(54;0.14)			41	165					2.24893e-16	3.26784e-16	1	0	A	139165165	A	A	139165165	3	1	194	1	0	0	0	0	1	0	0	0	5477	478	17	4	2699	4	FAM135B	8	139165165	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	13914	139165165	7198857	123	35620											
CYP11B2	1585	broad.mit.edu	37	chr8	143994844	143994844	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttccgagccagctcaaagagCgtcatcagcaagggaaacgc	13	5	11	12	3	3	1	3	0	0	1	4	3	4	2	2	1	5	2	2	1	3	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:143994844C>A	uc003yxk.1	-	6	981	c.978G>T	c.(976-978)ACG>ACT	p.T326T		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	326					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GCTCAAAGAGCGTCATCAGCA	0.622									Familial_Hyperaldosteronism_type_I				27	151					3.73148e-12	5.10925e-12	1	0	A	143994844	A	A	143994844	2	1	194	1	0	0	0	0	0	0	0	1	4163	755	27	3		3	CYP11B2	8	143994844	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	4829679	143994844	2369178	124	35621											
NAPRT1	93100	broad.mit.edu	37	chr8	144658323	144658323	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggactgactccagccagggCacctggaacctgccgcgtgg	8	5	14	14	2	0	1	0	1	0	0	1	3	1	3	5	4	3	1	5	4	1	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:144658323C>A	uc003yym.3	-	8	1057	c.1032G>T	c.(1030-1032)GTG>GTT	p.V344V	NAPRT1_uc003yyn.3_Silent_p.V344V|NAPRT1_uc011lkh.1_Silent_p.V344V|NAPRT1_uc003yyo.3_Silent_p.V344V	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	344					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCAGCCAGGGCACCTGGAACC	0.667													20	34					7.41877e-09	9.6743e-09	1	0	A	144658323	A	A	144658323	2	1	194	1	0	0	0	0	0	0	0	1	10218	697	25	4		4	NAPRT1	8	144658323	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	663479	144658323	1705699	125	35622											
DENND4C	55667	broad.mit.edu	37	chr9	19316463	19316463	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcaacttcccaaaaagccGtgcaaaaatctacttagcac	17	7	5	12	1	1	0	0	0	1	0	2	0	2	0	2	0	6	3	2	0	8	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:19316463G>T	uc003znq.2	+	7	861	c.828G>T	c.(826-828)CCG>CCT	p.P276P	DENND4C_uc011lnc.1_5'UTR	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	276						integral to membrane				ovary(1)|skin(1)	2						CCAAAAAGCCGTGCAAAAATC	0.328													11	2					7.03913e-09	9.21297e-09	1	0	T	19316463	T	T	19316463	2	4	194	1	0	0	0	0	0	0	0	1	4457	1132	40	3		3	DENND4C	9	19316463	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08		19316463	121896968	126	35623											
FAM75A6	389730	broad.mit.edu	37	chr9	43626706	43626706	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatgtgggcacaggtcccTctctagctggaacttcacct	8	10	10	13	0	2	1	1	0	1	1	4	2	3	2	2	3	2	2	2	3	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:43626706T>A	uc011lrb.1	-	4	2010	c.1981A>T	c.(1981-1983)AGG>TGG	p.R661W		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	661						integral to membrane					0						CACAGGTCCCTCTCTAGCTGG	0.562													71	13					0	0	0	0	A	43626706	A	A	43626706	3	1	194	1	0	0	0	0	1	0	0	0	5654	1550	54	5	2054	5	FAM75A6	9	43626706	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	24310243	43626706	97586725	127	35624											
PGM5	5239	broad.mit.edu	37	chr9	71098829	71098829	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acgacatattatatcatgagGgacctggaggccctggtcac	11	9	11	10	1	2	1	2	1	0	0	2	4	2	3	2	4	0	0	2	4	3	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:71098829G>T	uc004agr.2	+	9	1573	c.1344G>T	c.(1342-1344)AGG>AGT	p.R448S		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	448					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						ATATCATGAGGGACCTGGAGG	0.507													29	57					7.38237e-10	9.73379e-10	1	0	T	71098829	T	T	71098829	3	4	194	1	0	0	0	0	1	0	0	0	11856	1223	43	4	1378	4	PGM5	9	71098829	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	27472123	71098829	70114602	128	35625											
IARS	3376	broad.mit.edu	37	chr9	95009669	95009669	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agacacctaccagtcttctgGaactgctccagctcctcact	9	10	6	16	0	3	1	1	0	2	1	5	2	5	2	4	1	4	2	4	1	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:95009669G>T	uc004art.1	-	26	3038	c.2781C>A	c.(2779-2781)TTC>TTA	p.F927L	IARS_uc004ars.1_Missense_Mutation_p.F772L|IARS_uc004aru.3_Missense_Mutation_p.F927L|IARS_uc010mqr.2_Missense_Mutation_p.F817L|IARS_uc010mqt.2_Missense_Mutation_p.F150L	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	927					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	CAGTCTTCTGGAACTGCTCCA	0.473													24	53					2.24059e-21	3.45304e-21	1	0	T	95009669	T	T	95009669	3	4	194	1	0	0	0	0	1	0	0	0	7512	1165	41	2	1043	2	IARS	9	95009669	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	23910840	95009669	46203762	129	35626											
BAAT	570	broad.mit.edu	37	chr9	104133542	104133542	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaattcattggccctatagtGggcttgagaataaaacatgt	13	12	10	6	0	1	1	1	1	0	1	1	3	1	1	1	2	1	1	1	2	6	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:104133542G>A	uc010mtd.2	-	2	254	c.145C>T	c.(145-147)CAC>TAC	p.H49Y	BAAT_uc004bbd.3_Missense_Mutation_p.H49Y	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	49					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	GCCCTATAGTGGGCTTGAGAA	0.488													33	68					0	0	0	0	A	104133542	A	A	104133542	3	1	194	1	0	0	0	0	1	0	0	0	1282	1348	47	4	1123	4	BAAT	9	104133542	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	9123873	104133542	37079889	130	35627											
OR1N2	138882	broad.mit.edu	37	chr9	125315511	125315511	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgggaaaaccaggcagagtGaaccaaaccactgtttcaga	16	6	10	9	0	1	3	1	1	0	2	1	4	1	4	3	2	3	2	3	2	4	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:125315511G>C	uc011lyx.1	+	1	63	c.63G>C	c.(61-63)GTG>GTC	p.V21V		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						CAGGCAGAGTGAACCAAACCA	0.423													39	59					0	0	0	0	C	125315511	C	C	125315511	2	2	194	1	0	0	0	0	0	0	0	1	11024	1277	45	2		2	OR1N2	9	125315511	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	21181969	125315511	15897920	131	35628											
SETX	23064	broad.mit.edu	37	chr9	135203353	135203376	+	In_Frame_Del	DEL	CGTGAATTGGGAGTTGAAGTCCTT	-	-																															ccgtagtggctctctgaataCgtgaattgggagttgaagtc																										TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:135203353_135203376delCGTGAATTGGGAGTTGAAGTCCTT	uc004cbk.2	-	10	3792_3815	c.3609_3632delAAGGACTTCAACTCCCAATTCACG	c.(3607-3633)AGAAGGACTTCAACTCCCAATTCACGT>AGT	p.1203_1211RRTSTPNSR>S	SETX_uc004cbj.2_In_Frame_Del_p.822_830RRTSTPNSR>S|SETX_uc010mzt.2_In_Frame_Del_p.822_830RRTSTPNSR>S	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1203_1211					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCTCTGAATACGTGAATTGGGAGTTGAAGTCCTTCTATCAATAC	0.402													---	---	---								-	135203376	-	-	135203353	7	5	194	1	0	1	0	1	0	0	0	0	14206	536	19	0	4469	0	SETX	9	135203353	In_Frame_Del	DEL	CGTGAATTGGGAGTTGAAGTCCTT	TCGA-CV-6935-01A-11D-1912-08	9887842	135203353	6010078	132	35629											
SDCCAG3	10807	broad.mit.edu	37	chr9	139301763	139301763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggccctgccagctccgacGgggtggagaaaaaggaaagg	12	3	16	10	2	0	1	0	0	0	1	1	4	1	2	3	6	2	1	3	6	3	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:139301763G>A	uc004chi.2	-	5	858	c.653C>T	c.(652-654)CCG>CTG	p.P218L	SDCCAG3_uc004chj.2_Missense_Mutation_p.P195L|SDCCAG3_uc004chk.2_Missense_Mutation_p.P145L	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	218						cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		CAGCTCCGACGGGGTGGAGAA	0.657													11	8					0	0	0	0	A	139301763	A	A	139301763	3	1	194	1	0	0	0	0	1	0	0	0	14023	1116	39	1	678	1	SDCCAG3	9	139301763	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	4098410	139301763	1911668	133	35630											
MAMDC4	158056	broad.mit.edu	37	chr9	139754408	139754408	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctattgctcatgctcctggtGctgctgggacttgggggacg	4	12	15	10	1	1	0	1	0	0	0	2	2	2	2	1	4	4	4	1	4	1	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:139754408G>A	uc004cjs.2	+	26	3314	c.3264G>A	c.(3262-3264)GTG>GTA	p.V1088V	MAMDC4_uc011mej.1_Silent_p.V425V	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	1167	Helical; (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		TGCTCCTGGTGCTGCTGGGAC	0.627													24	29					0	0	0	0	A	139754408	A	A	139754408	2	1	194	1	0	0	0	0	0	0	0	1	9257	1306	46	4		4	MAMDC4	9	139754408	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	452645	139754408	1459023	134	35631											
NELF	26012	broad.mit.edu	37	chr9	140346851	140346851	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcattttccagatcttggctCccttgtggtagacgttcagc	6	14	10	11	1	2	2	1	0	1	2	4	2	4	2	2	2	1	4	2	2	1	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:140346851C>G	uc004cna.2	-	12	1434	c.1202G>C	c.(1201-1203)GGA>GCA	p.G401A	C9orf167_uc011mew.1_Intron|NELF_uc011mex.1_Missense_Mutation_p.G198A|NELF_uc010nci.2_Missense_Mutation_p.G145A|NELF_uc011mey.1_RNA|NELF_uc011mez.1_Missense_Mutation_p.G378A|NELF_uc004cmz.2_Missense_Mutation_p.G399A|NELF_uc004cnc.2_Missense_Mutation_p.G376A|NELF_uc004cnb.2_Missense_Mutation_p.G371A	NM_001130969	NP_001124441	Q6X4W1	NELF_HUMAN	nasal embryonic LHRH factor isoform a	401						nucleus|plasma membrane					0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000222)|Epithelial(140;0.000888)		GATCTTGGCTCCCTTGTGGTA	0.617													59	121					0	0	0	0	G	140346851	G	G	140346851	3	3	194	1	0	0	0	0	1	0	0	0	10386	855	30	2	410	2	NELF	9	140346851	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	592443	140346851	866580	135	35632											
FAM188A	80013	broad.mit.edu	37	chr10	15828592	15828592	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaattcttgaagaaatgggcCcaataatatgattcctaatc	16	12	6	7	0	1	3	0	2	1	1	3	3	2	3	2	1	0	0	2	1	7	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:15828592C>A	uc001iod.1	-	13	1305	c.1084G>T	c.(1084-1086)GGC>TGC	p.G362C	FAM188A_uc001ioe.1_Missense_Mutation_p.G189C	NM_024948	NP_079224	Q9H8M7	F188A_HUMAN	chromosome 10 open reading frame 97	362					apoptosis	nucleus	calcium ion binding			ovary(1)	1						AGAAATGGGCCCAATAATATG	0.338													38	77					6.97489e-18	1.03032e-17	1	0	A	15828592	A	A	15828592	3	1	194	1	0	0	0	0	1	0	0	0	5542	623	22	4	265	4	FAM188A	10	15828592	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08		15828592	119706155	136	35633											
KIAA1217	56243	broad.mit.edu	37	chr10	24727394	24727394	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacacaccaaaaactatgAatggagacatgagggtaagt	18	7	9	7	0	1	3	1	2	0	1	1	4	1	3	1	2	1	1	1	2	5	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:24727394A>G	uc001iru.3	+	5	1235	c.832A>G	c.(832-834)AAT>GAT	p.N278D	KIAA1217_uc001irs.2_Missense_Mutation_p.N198D|KIAA1217_uc001irt.3_Missense_Mutation_p.N278D|KIAA1217_uc010qcy.1_Missense_Mutation_p.N278D|KIAA1217_uc010qcz.1_Missense_Mutation_p.N278D|KIAA1217_uc001irv.1_Missense_Mutation_p.N128D|KIAA1217_uc010qda.1_RNA	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	278					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						AAAAACTATGAATGGAGACAT	0.403													43	56					0	0	0	0	G	24727394	G	G	24727394	3	3	194	1	0	0	0	0	1	0	0	0	8255	246	9	5	850	5	KIAA1217	10	24727394	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	8898802	24727394	110807353	137	35634											
PPYR1	5540	broad.mit.edu	37	chr10	47087602	47087602	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtggtgatggtggtggcCtttgctgtgctctggctgcc	1	14	17	9	0	1	1	0	1	1	0	1	1	1	1	2	6	3	3	2	6	0	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:47087602C>A	uc001jee.2	+	3	1238	c.819C>A	c.(817-819)GCC>GCA	p.A273A	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.A273A	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	273	Helical; Name=6; (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						TGGTGGTGGCCTTTGCTGTGC	0.587													20	87					3.99206e-14	5.59517e-14	1	0	A	47087602	A	A	47087602	2	1	194	1	0	0	0	0	0	0	0	1	12476	668	24	4		4	PPYR1	10	47087602	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	22360208	47087602	88447145	138	35635											
OGDHL	55753	broad.mit.edu	37	chr10	50945898	50945898	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagagatttaggtgtgaagaTaatcagctggaagggaaata	16	9	13	3	0	1	3	1	1	0	2	1	6	1	5	0	3	1	1	0	3	6	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:50945898T>A	uc001jie.2	-	20	2666	c.2524A>T	c.(2524-2526)ATC>TTC	p.I842F	OGDHL_uc009xog.2_Missense_Mutation_p.I869F|OGDHL_uc010qgt.1_Missense_Mutation_p.I785F|OGDHL_uc010qgu.1_Missense_Mutation_p.I633F	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	842					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGTGTGAAGATAATCAGCTGG	0.617													33	50					0	0	0	0	A	50945898	A	A	50945898	3	1	194	1	0	0	0	0	1	0	0	0	10894	1406	49	5	524	5	OGDHL	10	50945898	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	3858296	50945898	84588849	139	35636											
PCDH15	65217	broad.mit.edu	37	chr10	56106133	56106133	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatttacataccggatcatCtggattatactgaataacat	14	14	6	7	1	2	1	1	1	1	0	2	3	2	3	1	2	4	1	1	2	7	7			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:56106133C>A	uc001jju.1	-	6	981	c.586G>T	c.(586-588)GAT>TAT	p.D196Y	PCDH15_uc010qhq.1_Missense_Mutation_p.D201Y|PCDH15_uc010qhr.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhs.1_Missense_Mutation_p.D201Y|PCDH15_uc010qht.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhu.1_Missense_Mutation_p.D196Y|PCDH15_uc001jjv.1_Missense_Mutation_p.D174Y|PCDH15_uc010qhv.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhw.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhx.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhy.1_Missense_Mutation_p.D201Y|PCDH15_uc010qhz.1_Missense_Mutation_p.D196Y|PCDH15_uc010qia.1_Missense_Mutation_p.D174Y|PCDH15_uc010qib.1_Missense_Mutation_p.D174Y|PCDH15_uc001jjw.2_Missense_Mutation_p.D196Y	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	196	Extracellular (Potential).|Cadherin 2.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACCGGATCATCTGGATTATAC	0.308										HNSCC(58;0.16)			26	59					1.66031e-10	2.21374e-10	1	0	A	56106133	A	A	56106133	3	1	194	1	0	0	0	0	1	0	0	0	11565	913	32	2	7037	2	PCDH15	10	56106133	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	5160235	56106133	79428614	140	35637											
GLUD1	2746	broad.mit.edu	37	chr10	88836358	88836358	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgcacacttgtatgtcatCagagaagccaaagcttttac	13	11	7	10	0	2	1	2	0	0	1	2	2	2	1	1	0	4	3	1	0	4	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:88836358C>T	uc001keh.2	-	2	598	c.501G>A	c.(499-501)CTG>CTA	p.L167L	GLUD1_uc001keg.2_5'UTR|GLUD1_uc010qmp.1_Silent_p.L34L	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	167					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)	TGTATGTCATCAGAGAAGCCA	0.413													25	36					0	0	0	0	T	88836358	T	T	88836358	2	4	194	1	0	0	0	0	0	0	0	1	6513	813	29	2		2	GLUD1	10	88836358	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	32730225	88836358	46698389	141	35638											
PKD2L1	9033	broad.mit.edu	37	chr10	102050202	102050202	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcctcctgctctggcagcCtctggacccgatttgccttg	4	11	10	16	1	2	0	0	0	2	0	3	2	3	1	5	2	4	2	5	2	0	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:102050202C>A	uc001kqx.1	-	13	2465	c.2082G>T	c.(2080-2082)GAG>GAT	p.E694D	PKD2L1_uc009xwm.1_Missense_Mutation_p.E647D	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	694	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CTCTGGCAGCCTCTGGACCCG	0.527													8	23					0.000157383	0.000191878	1	0	A	102050202	A	A	102050202	3	1	194	1	0	0	0	0	1	0	0	0	12022	680	24	4	351	4	PKD2L1	10	102050202	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	13213844	102050202	33484545	142	35639											
WNT8B	7479	broad.mit.edu	37	chr10	102241771	102241771	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaacaggacaggatgcacGggcagccatgaacctgcaca	14	3	13	11	1	0	1	0	1	0	0	0	4	0	4	2	4	5	3	2	4	2	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:102241771G>A	uc001krb.2	+	5	584	c.470G>A	c.(469-471)CGG>CAG	p.R157Q		NM_003393	NP_003384	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family,	157					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(1)|breast(1)|large_intestine(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		CAGGATGCACGGGCAGCCATG	0.592											OREG0020440	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	48					0	0	0	0	A	102241771	A	A	102241771	3	1	194	1	0	0	0	0	1	0	0	0	17465	1116	39	1	488	1	WNT8B	10	102241771	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	191569	102241771	33292976	143	35640											
C10orf79	80217	broad.mit.edu	37	chr10	105893540	105893540	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaactttcttttgtccttgAgtctttaaaaaagtacatta	12	17	5	7	0	2	1	0	1	2	0	3	1	3	1	1	0	2	2	1	0	6	8			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:105893540A>G	uc001kxw.2	-	35	4550	c.4434T>C	c.(4432-4434)ACT>ACC	p.T1478T	C10orf79_uc009xxq.2_Silent_p.T757T	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1478											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TTTGTCCTTGAGTCTTTAAAA	0.318													15	31					0	0	0	0	G	105893540	G	G	105893540	2	3	194	1	0	0	0	0	0	0	0	1	1624	291	11	5		5	C10orf79	10	105893540	Silent	SNP	A	TCGA-CV-6935-01A-11D-1912-08	3651769	105893540	29641207	144	35641											
MUC5B	727897	broad.mit.edu	37	chr11	1263788	1263788	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagtaccccagccaccagctCcacggccacgccctcctcaa	9	4	6	22	2	1	0	1	0	0	0	3	0	3	0	8	1	3	2	8	1	2	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:1263788C>A	uc009ycr.1	+	47	7883	c.7757C>A	c.(7756-7758)TCC>TAC	p.S2586Y	MUC5B_uc001ltb.2_Missense_Mutation_p.S1896Y	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1893	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCACCAGCTCCACGGCCACG	0.612													45	81					1.86633e-21	2.88876e-21	1	0	A	1263788	A	A	1263788	3	1	194	1	0	0	0	0	1	0	0	0	10032	855	30	2	5809	2	MUC5B	11	1263788	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08		1263788	133742728	145	35642											
OR52L1	338751	broad.mit.edu	37	chr11	6007529	6007529	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccataagctcgattgactGtggtttctgagcaggcaagt	9	11	12	9	1	1	2	0	2	1	0	2	3	1	2	1	2	2	4	1	2	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:6007529G>T	uc001mcd.2	-	1	687	c.632C>A	c.(631-633)ACA>AAA	p.T211K		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	211	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCGATTGACTGTGGTTTCTGA	0.493													55	99					5.22555e-25	8.19514e-25	1	0	T	6007529	T	T	6007529	3	4	194	1	0	0	0	0	1	0	0	0	11179	1377	48	4	361	4	OR52L1	11	6007529	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	4743741	6007529	128998987	146	35643											
DCHS1	8642	broad.mit.edu	37	chr11	6643935	6643935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtggactaggtggctccCggcccagtttctgcagtgag	5	10	16	10	1	1	1	0	1	1	0	2	2	2	2	2	5	1	3	2	5	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:6643935C>T	uc001mem.1	-	21	9382	c.8972G>A	c.(8971-8973)CGG>CAG	p.R2991Q		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2991	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGTGGCTCCCGGCCCAGTTT	0.642													5	5					0	0	0	0	T	6643935	T	T	6643935	3	4	194	1	0	0	0	0	1	0	0	0	4304	652	23	1	928	1	DCHS1	11	6643935	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	636406	6643935	128362581	147	35644											
OR5P2	120065	broad.mit.edu	37	chr11	7818034	7818034	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggaagtagtataggagacAgcaatgagaaaaccagctat	19	6	11	5	0	0	2	0	1	0	2	0	5	0	3	1	2	3	4	1	2	9	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:7818034A>G	uc001mfp.1	-	1	456	c.456T>C	c.(454-456)GCT>GCC	p.A152A		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TATAGGAGACAGCAATGAGAA	0.388													31	44					0	0	0	0	G	7818034	G	G	7818034	2	3	194	1	0	0	0	0	0	0	0	1	11232	175	7	5		5	OR5P2	11	7818034	Silent	SNP	A	TCGA-CV-6935-01A-11D-1912-08	1174099	7818034	127188482	148	35645											
ST5	6764	broad.mit.edu	37	chr11	8737301	8737301	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgggtaatcgtggcagcCggtggctcttcctttctgac	4	14	12	11	2	3	1	0	1	3	0	5	1	4	1	2	4	1	3	2	4	1	4	rs35353984		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:8737301C>T	uc001mgt.2	-	6	1880	c.1694G>A	c.(1693-1695)CGG>CAG	p.R565Q	ST5_uc009yfr.2_Missense_Mutation_p.R145Q|ST5_uc001mgu.2_Missense_Mutation_p.R145Q|ST5_uc001mgv.2_Missense_Mutation_p.R565Q|ST5_uc010rbq.1_RNA|ST5_uc010rbp.1_Missense_Mutation_p.R78Q	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	565					positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		TCGTGGCAGCCGGTGGCTCTT	0.617													41	80					0	0	0	0	T	8737301	T	T	8737301	3	4	194	1	0	0	0	0	1	0	0	0	15286	652	23	1	1779	1	ST5	11	8737301	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	919267	8737301	126269215	149	35646											
ANO5	203859	broad.mit.edu	37	chr11	22301128	22301128	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatttttgctggcctggatGatacctgatgttccaaaaga	12	13	9	7	0	0	3	0	2	0	1	1	4	1	4	3	2	2	2	3	2	4	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:22301128G>T	uc001mqi.2	+	22	2876	c.2559G>T	c.(2557-2559)ATG>ATT	p.M853I	ANO5_uc001mqj.2_Missense_Mutation_p.M852I	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	853	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TGGCCTGGATGATACCTGATG	0.358													17	37					0.00074312	0.000899833	1	0	T	22301128	T	T	22301128	3	4	194	1	0	0	0	0	1	0	0	0	700	1290	45	2	2645	2	ANO5	11	22301128	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	13563827	22301128	112705388	150	35647											
LRP4	4038	broad.mit.edu	37	chr11	46908046	46908046	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaaagctgattcgacggaTgtccatccttcgggcaaaaa	12	9	10	10	3	1	1	1	1	0	0	5	3	3	2	2	2	1	2	2	2	3	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:46908046T>C	uc001ndn.3	-	17	2400	c.2254A>G	c.(2254-2256)ATC>GTC	p.I752V		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	752	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		ATTCGACGGATGTCCATCCTT	0.517													25	34					0	0	0	0	C	46908046	C	C	46908046	3	2	194	1	0	0	0	0	1	0	0	0	9009	1464	51	5	3551	5	LRP4	11	46908046	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	24606918	46908046	88098470	151	35648											
OR4X2	119764	broad.mit.edu	37	chr11	48267430	48267430	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccttctaccactctgcccAtagacaagatggtggctgtg	8	10	11	12	0	2	2	0	0	2	2	2	2	2	2	3	3	2	1	3	3	3	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:48267430A>G	uc001ngs.1	+	1	775	c.775A>G	c.(775-777)ATA>GTA	p.I259V		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACTCTGCCCATAGACAAGAT	0.512													26	32					0	0	0	0	G	48267430	G	G	48267430	3	3	194	1	0	0	0	0	1	0	0	0	11139	217	8	5	777	5	OR4X2	11	48267430	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	1359384	48267430	86739086	152	35649											
OR4A47	403253	broad.mit.edu	37	chr11	48511249	48511249	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgaagaagctctggagaaGagacctcatatcaagtagta	16	9	10	6	0	3	4	2	1	1	3	3	6	3	4	1	1	1	3	1	1	8	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:48511249G>T	uc010rhx.1	+	1	905	c.905G>T	c.(904-906)AGA>ATA	p.R302I		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTCTGGAGAAGAGACCTCATA	0.413													28	50					1.77063e-15	2.54171e-15	1	0	T	48511249	T	T	48511249	3	4	194	1	0	0	0	0	1	0	0	0	11096	942	33	2	907	2	OR4A47	11	48511249	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	243819	48511249	86495267	153	35650											
OR4C46	119749	broad.mit.edu	37	chr11	51515722	51515722	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgctaatgggagtggtgtgGatgggaggctttcttcatgc	6	13	16	6	0	2	0	1	0	1	0	2	3	2	3	0	5	2	2	0	5	1	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:51515722G>T	uc010ric.1	+	1	441	c.441G>T	c.(439-441)TGG>TGT	p.W147C		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAGTGGTGTGGATGGGAGGCT	0.463													75	119					1.15098e-32	1.88824e-32	1	0	T	51515722	T	T	51515722	3	4	194	1	0	0	0	0	1	0	0	0	11105	1183	41	2	443	2	OR4C46	11	51515722	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	3004473	51515722	83490794	154	35651											
OR5T3	390154	broad.mit.edu	37	chr11	56019812	56019812	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caccatgtttatattgacagGcttcacagatgattttgagc	11	14	8	8	0	1	4	1	3	0	1	1	4	1	4	1	1	1	2	1	1	2	7			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:56019812G>C	uc010rjd.1	+	1	137	c.137G>C	c.(136-138)GGC>GCC	p.G46A		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	46	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					ATATTGACAGGCTTCACAGAT	0.373													41	67					0	0	0	0	C	56019812	C	C	56019812	3	2	194	1	0	0	0	0	1	0	0	0	11237	1203	42	4	139	4	OR5T3	11	56019812	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	4504090	56019812	78986704	155	35652											
OR5M1	390168	broad.mit.edu	37	chr11	56380788	56380788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtctacaaaggagaggtggCcaaggaagaaatacatgggt	15	7	14	5	0	1	2	0	0	1	2	1	4	1	3	1	5	2	0	1	5	6	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:56380788C>T	uc001nja.1	-	1	191	c.191G>A	c.(190-192)GGC>GAC	p.G64D		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GGAGAGGTGGCCAAGGAAGAA	0.468													44	80					0	0	0	0	T	56380788	T	T	56380788	3	4	194	1	0	0	0	0	1	0	0	0	11226	739	26	4	760	4	OR5M1	11	56380788	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	360976	56380788	78625728	156	35653											
ACY3	91703	broad.mit.edu	37	chr11	67410230	67410230	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cggggcaggggtcagcgcggGcatggcaggcacggtgaatg	7	4	21	9	4	1	1	1	1	0	0	1	1	1	1	0	8	1	4	0	8	1	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:67410230G>T	uc001omq.2	-	8	1096	c.925C>A	c.(925-927)CCC>ACC	p.P309T		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	309					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	GTCAGCGCGGGCATGGCAGGC	0.587													45	98					4.78724e-31	7.782e-31	1	0	T	67410230	T	T	67410230	3	4	194	1	0	0	0	0	1	0	0	0	227	1203	42	4	38	4	ACY3	11	67410230	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	11029442	67410230	67596286	157	35654											
LRP5	4041	broad.mit.edu	37	chr11	68154175	68154175	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccatcgcactgcaccccgtGatggggtaagacgggcgggg	7	5	17	12	4	0	2	0	1	0	1	1	2	0	2	3	5	1	3	3	5	1	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:68154175G>A	uc001ont.2	+	6	1482	c.1407G>A	c.(1405-1407)GTG>GTA	p.V469V	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	469	LDL-receptor class B 7.|Beta-propeller 2.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						TGCACCCCGTGATGGGGTAAG	0.672													13	27					0	0	0	0	A	68154175	A	A	68154175	2	1	194	1	0	0	0	0	0	0	0	1	9010	1277	45	2		2	LRP5	11	68154175	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	743945	68154175	66852341	158	35655											
P2RY2	5029	broad.mit.edu	37	chr11	72946311	72946311	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagtccacgccggctggtagCgagaacactaaggacattcg	11	6	13	11	4	0	1	0	0	0	1	2	4	1	2	2	3	2	2	2	3	3	3	rs145119561	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:72946311C>G	uc001otj.2	+	3	1440	c.1107C>G	c.(1105-1107)AGC>AGG	p.S369R	P2RY2_uc001otk.2_Missense_Mutation_p.S369R|P2RY2_uc001otl.2_Missense_Mutation_p.S369R	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	369	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	CGGCTGGTAGCGAGAACACTA	0.552													47	35					0	0	0	0	G	72946311	G	G	72946311	3	3	194	1	0	0	0	0	1	0	0	0	11406	767	27	3	1109	3	P2RY2	11	72946311	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	4792136	72946311	62060205	159	35656											
RELT	84957	broad.mit.edu	37	chr11	73101965	73101965	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgtggagactgctggcctGggtaagccaaagggagtgcg	8	8	17	8	1	1	1	0	0	1	1	1	3	1	2	2	4	3	2	2	4	2	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:73101965G>T	uc001otv.2	+	4	451	c.286G>T	c.(286-288)GGG>TGG	p.G96W	RELT_uc001otw.2_Missense_Mutation_p.G96W|RELT_uc009yto.1_Missense_Mutation_p.G14W|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	96	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						CTGCTGGCCTGGGTAAGCCAA	0.602													24	19					1.77063e-15	2.54171e-15	1	0	T	73101965	T	T	73101965	3	4	194	1	0	0	0	0	1	0	0	0	13286	1362	47	4	296	4	RELT	11	73101965	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	155654	73101965	61904551	160	35657											
OR2AT4	341152	broad.mit.edu	37	chr11	74800246	74800246	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taggcaatgctgttatatgcCatctgggaggtccttactac	9	13	10	9	0	1	0	0	0	1	0	2	1	2	1	2	3	4	3	2	3	6	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:74800246C>G	uc010rro.1	-	1	513	c.513G>C	c.(511-513)ATG>ATC	p.M171I		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGTTATATGCCATCTGGGAGG	0.572													25	9					0	0	0	0	G	74800246	G	G	74800246	3	3	194	1	0	0	0	0	1	0	0	0	11041	594	21	4	452	4	OR2AT4	11	74800246	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	1698281	74800246	60206270	161	35658											
MYO7A	4647	broad.mit.edu	37	chr11	76916513	76916513	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctcctcctgcaggtacagCgaggagcggggttgggagct	6	7	17	11	2	0	0	0	0	0	0	2	3	2	2	3	5	5	4	3	5	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:76916513C>T	uc001oyb.2	+	40	5759	c.5487C>T	c.(5485-5487)AGC>AGT	p.S1829S	MYO7A_uc001oyc.2_Silent_p.S1791S|MYO7A_uc001oye.2_Intron	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1829	MyTH4 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GCAGGTACAGCGAGGAGCGGG	0.677													5	0					0	0	0	0	T	76916513	T	T	76916513	2	4	194	1	0	0	0	0	0	0	0	1	10135	767	27	1		1	MYO7A	11	76916513	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	2116267	76916513	58090003	162	35659											
MMP13	4322	broad.mit.edu	37	chr11	102818711	102818711	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttaacttcttttggaagacCcagttcagatatttttttgg	9	18	7	7	0	2	2	1	0	1	2	2	3	2	3	1	2	1	1	1	2	3	9			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:102818711C>G	uc001phl.2	-	8	1148	c.1120G>C	c.(1120-1122)GGT>CGT	p.G374R		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	374	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TTTGGAAGACCCAGTTCAGAT	0.403													21	13					0	0	0	0	G	102818711	G	G	102818711	3	3	194	1	0	0	0	0	1	0	0	0	9705	623	22	4	307	4	MMP13	11	102818711	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	25902198	102818711	32187805	163	35660											
GRIA4	2893	broad.mit.edu	37	chr11	105789531	105789531	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagatttggcatctgaaattGcaaaacatattggtatcaag	15	13	8	5	0	2	2	1	1	1	1	2	2	2	2	0	2	2	3	0	2	7	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:105789531G>C	uc001pix.2	+	11	1809	c.1363G>C	c.(1363-1365)GCA>CCA	p.A455P	GRIA4_uc001piw.2_Missense_Mutation_p.A455P	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	455	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATCTGAAATTGCAAAACATAT	0.353													13	5					0	0	0	0	C	105789531	C	C	105789531	3	2	194	1	0	0	0	0	1	0	0	0	6809	1319	46	4	1438	4	GRIA4	11	105789531	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	2970820	105789531	29216985	164	35661											
FGF23	8074	broad.mit.edu	37	chr12	4479740	4479740	+	Frame_Shift_Del	DEL	C	-	-																															tcggcgctccgggtgtgccgCcgtggtatgggggtgttgaa																										TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:4479740delC	uc001qmq.1	-	3	671	c.525delG	c.(523-525)CGGfs	p.R175fs		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	175					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			GGGTGTGCCGCCGTGGTATGG	0.672													---	---	---								-	4479740	-	-	4479740	7	5	194	1	0	1	0	1	0	0	0	0	5884	726	26	0	234	0	FGF23	12	4479740	Frame_Shift_Del	DEL	C	TCGA-CV-6935-01A-11D-1912-08		4479740	129372155	165	35662											
PRB2	653247	broad.mit.edu	37	chr12	11546873	11546873	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggagatgggggaccttgagGtttgttgcctccttgtgggg	5	12	18	6	0	0	2	0	1	0	1	1	4	1	3	3	6	1	2	3	6	0	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:11546873G>T	uc010shk.1	-	3	174	c.139C>A	c.(139-141)CCT>ACT	p.P47T		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGACCTTGAGGTTTGTTGCCT	0.537													144	181					2.60356e-62	4.39273e-62	1	0	T	11546873	T	T	11546873	3	4	194	1	0	0	0	0	1	0	0	0	12505	1261	44	4	1115	4	PRB2	12	11546873	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	7067133	11546873	122305022	166	35663											
FAM60A	58516	broad.mit.edu	37	chr12	31435799	31435799	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagatgatcccacaacatatCttctgtctaaaagaaaaaat	18	11	4	8	0	3	3	0	1	3	2	4	3	4	3	1	0	1	0	1	0	8	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:31435799C>T	uc010sjz.1	-	6	752	c.513G>A	c.(511-513)AAG>AAA	p.K171K	FAM60A_uc001rkd.2_Silent_p.K171K|FAM60A_uc010ska.1_Silent_p.K171K|FAM60A_uc001rke.2_Silent_p.K171K|FAM60A_uc010skb.1_RNA|FAM60A_uc001rkc.2_Silent_p.K196K	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	171											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					CACAACATATCTTCTGTCTAA	0.353													17	29					0	0	0	0	T	31435799	T	T	31435799	2	4	194	1	0	0	0	0	0	0	0	1	5627	912	32	2		2	FAM60A	12	31435799	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	19888926	31435799	102416096	167	35664											
ABCD2	225	broad.mit.edu	37	chr12	39947723	39947723	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcaaaacaaattaagatgtCtcatcttcatttttaattgt	14	17	4	6	0	4	1	3	0	2	1	5	1	4	1	0	0	1	0	0	0	5	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:39947723C>G	uc001rmb.2	-	10	2640	c.2214G>C	c.(2212-2214)GAG>GAC	p.E738D		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	738					fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						ATTAAGATGTCTCATCTTCAT	0.323													4	7					0	0	0	0	G	39947723	G	G	39947723	3	3	194	1	0	0	0	0	1	0	0	0	61	912	32	2	12	2	ABCD2	12	39947723	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	8511924	39947723	93904172	168	35665											
PPFIA2	8499	broad.mit.edu	37	chr12	81738464	81738464	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctccgatgtttcctcagAtcacttggctgtgattggca	6	16	9	10	1	3	2	2	1	1	1	5	3	4	2	2	2	0	3	2	2	0	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:81738464A>T	uc001szo.1	-	19	2402	c.2241T>A	c.(2239-2241)GAT>GAA	p.D747E	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	673										ovary(3)|lung(2)|pancreas(1)	6						GTTTCCTCAGATCACTTGGCT	0.279													3	0					0	0	0	0	T	81738464	T	T	81738464	3	4	194	1	0	0	0	0	1	0	0	0	12365	330	12	5	1588	5	PPFIA2	12	81738464	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	41790741	81738464	52113431	169	35666											
DUSP6	1848	broad.mit.edu	37	chr12	89745444	89745444	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtagaacgcccggcagccctCgtccttgagcttcttgagca	7	9	11	14	3	1	3	0	2	1	1	3	3	2	3	3	1	4	4	3	1	2	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:89745444C>T	uc001tay.2	-	1	853	c.373G>A	c.(373-375)GAG>AAG	p.E125K	DUSP6_uc001taz.2_Missense_Mutation_p.E125K	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	125	Rhodanese.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						CGGCAGCCCTCGTCCTTGAGC	0.687													6	2					0	0	0	0	T	89745444	T	T	89745444	3	4	194	1	0	0	0	0	1	0	0	0	4851	893	31	1	784	1	DUSP6	12	89745444	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	8006980	89745444	44106451	170	35667											
LUM	4060	broad.mit.edu	37	chr12	91502199	91502199	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aagctcaagtcaaggtattcGagtgatttaagacctttaaa	15	12	8	6	1	2	2	2	1	0	1	3	3	2	2	1	1	1	2	1	1	7	6	rs144214151		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:91502199G>C	uc001tbm.2	-	2	947	c.558C>G	c.(556-558)CTC>CTG	p.L186L	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	186	LRR 6.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						CAAGGTATTCGAGTGATTTAA	0.433													40	12					0	0	0	0	C	91502199	C	C	91502199	2	2	194	1	0	0	0	0	0	0	0	1	9135	1045	37	3		3	LUM	12	91502199	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	1756755	91502199	42349696	171	35668											
C12orf51	283450	broad.mit.edu	37	chr12	112622228	112622228	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggatgggcagctcgaggccGgcaggcagcggatccacaga	9	3	18	11	3	0	1	0	0	0	1	2	4	1	3	2	6	2	4	2	6	0	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:112622228G>A	uc009zwc.2	-	54	9294	c.9276C>T	c.(9274-9276)GCC>GCT	p.A3092A		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GCTCGAGGCCGGCAGGCAGCG	0.627													11	1					0	0	0	0	A	112622228	A	A	112622228	2	1	194	1	0	0	0	0	0	0	0	1	1702	1103	39	1		1	C12orf51	12	112622228	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	21120029	112622228	21229667	172	35669											
TBX3	6926	broad.mit.edu	37	chr12	115109999	115109999	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtgttcagattgaggaaggGgtggcggtgcaccgagctgg	7	8	20	6	2	1	2	1	1	0	1	1	4	1	3	1	7	2	3	1	7	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:115109999G>A	uc001tvt.1	-	8	2843	c.1879C>T	c.(1879-1881)CCC>TCC	p.P627S	TBX3_uc001tvu.1_Missense_Mutation_p.P607S	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	627	Transcription repression.			SAAASSSVHRHPF -> LRQPQLRCTAPL (in Ref. 1).	anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		TTGAGGAAGGGGTGGCGGTGC	0.682													3	2					0	0	0	0	A	115109999	A	A	115109999	3	1	194	1	0	0	0	0	1	0	0	0	15725	1232	43	4	356	4	TBX3	12	115109999	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	2487771	115109999	18741896	173	35670											
HNF1A	6927	broad.mit.edu	37	chr12	121438953	121438953	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatccaaccacagcgtcatCgagaccttcatctccaccca	11	7	4	19	2	3	1	2	0	1	1	6	2	4	1	6	0	2	0	6	0	1	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:121438953C>A	uc001tzg.2	+	10	1877	c.1854C>A	c.(1852-1854)ATC>ATA	p.I618I	HNF1A_uc010szn.1_Silent_p.I625I	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	618			I -> M (in MODY3).		glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACAGCGTCATCGAGACCTTCA	0.617									Hepatic_Adenoma_Familial_Clustering_of				10	5					1.58986e-06	1.99997e-06	1	0	A	121438953	A	A	121438953	2	1	194	1	0	0	0	0	0	0	0	1	7290	874	31	3		3	HNF1A	12	121438953	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	6328954	121438953	12412942	174	35671											
CDK8	1024	broad.mit.edu	37	chr13	26911771	26911771	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctctatgtcggcatgtagaGaaatagcagtaagtgaagtt	13	12	11	5	1	1	2	0	1	1	1	3	3	1	2	0	1	1	5	0	1	6	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:26911771G>C	uc001uqr.1	+	2	222	c.196G>C	c.(196-198)GAA>CAA	p.E66Q	CDK8_uc001uqs.1_Missense_Mutation_p.E66Q|CDK8_uc001uqt.1_5'UTR	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	66	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		GGCATGTAGAGAAATAGCAGT	0.289													30	51					0	0	0	0	C	26911771	C	C	26911771	3	2	194	1	0	0	0	0	1	0	0	0	3165	943	33	2	202	2	CDK8	13	26911771	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08		26911771	88258107	175	35672											
ALG5	29880	broad.mit.edu	37	chr13	37524134	37524134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccagtcaaatatcgaagtCgtataaaaagtaggtcttta	16	11	7	7	2	2	0	1	0	1	0	4	1	2	0	1	1	0	2	1	1	9	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:37524134C>T	uc001uvy.2	-	10	987	c.920G>A	c.(919-921)CGA>CAA	p.R307Q	ALG5_uc010teq.1_Missense_Mutation_p.R277Q|ALG5_uc010ter.1_RNA	NM_013338	NP_037470	Q9Y673	ALG5_HUMAN	dolichyl-phosphate beta-glucosyltransferase	307	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate beta-glucosyltransferase activity|oligosaccharyl transferase activity				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;5.79e-07)|Epithelial(112;1.81e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00785)|BRCA - Breast invasive adenocarcinoma(63;0.0127)|GBM - Glioblastoma multiforme(144;0.0472)		ATATCGAAGTCGTATAAAAAG	0.353													16	33					0	0	0	0	T	37524134	T	T	37524134	3	4	194	1	0	0	0	0	1	0	0	0	521	884	31	1	58	1	ALG5	13	37524134	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	10612363	37524134	77645744	176	35673											
FREM2	341640	broad.mit.edu	37	chr13	39446956	39446956	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgttccattcccccgtgggGgtaggaggctggcagcattt	5	11	15	10	1	0	0	0	0	0	0	2	1	2	1	3	5	1	5	3	5	1	4	rs147947821		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:39446956G>T	uc001uwv.2	+	17	8370	c.8061G>T	c.(8059-8061)GGG>GGT	p.G2687G		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2687	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCCCCGTGGGGGTAGGAGGCT	0.488													40	64					9.8876e-21	1.51724e-20	1	0	T	39446956	T	T	39446956	2	4	194	1	0	0	0	0	0	0	0	1	6079	1219	43	4		4	FREM2	13	39446956	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	1922822	39446956	75722922	177	35674											
HTR2A	3356	broad.mit.edu	37	chr13	47409480	47409480	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctgcctgtgtaggaccctGgctccctatggatcgaccgc	5	10	11	15	2	0	0	0	0	0	0	3	3	2	2	5	3	1	2	5	3	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:47409480G>A	uc001vbq.2	-	3	1042	c.908C>T	c.(907-909)CCA>CTA	p.P303L	HTR2A_uc001vbr.2_Missense_Mutation_p.P203L|HTR2A_uc010acr.2_Missense_Mutation_p.P303L	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	303	Cytoplasmic (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GTAGGACCCTGGCTCCCTATG	0.517													21	29					0	0	0	0	A	47409480	A	A	47409480	3	1	194	1	0	0	0	0	1	0	0	0	7480	1348	47	4	511	4	HTR2A	13	47409480	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	7962524	47409480	67760398	178	35675											
SLC15A1	6564	broad.mit.edu	37	chr13	99364806	99364806	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccctcttgggaaatgccttActccgatgcctaaatctatt	9	14	6	12	1	2	0	0	0	2	0	4	2	4	1	4	1	3	0	4	1	5	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:99364806A>G	uc001vno.2	-	10	833	c.756T>C	c.(754-756)AGT>AGC	p.S252S		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	252	Cytoplasmic (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	GAAATGCCTTACTCCGATGCC	0.433													37	92					0	0	0	0	G	99364806	G	G	99364806	2	3	194	1	0	0	0	0	0	0	0	1	14463	388	14	5		5	SLC15A1	13	99364806	Silent	SNP	A	TCGA-CV-6935-01A-11D-1912-08	51955326	99364806	15805072	179	35676											
DOCK9	23348	broad.mit.edu	37	chr13	99452600	99452600	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgatcatgtccacctcggccGaggagcacagctgccggagc	8	6	13	14	3	1	1	1	1	0	0	3	4	2	3	4	3	4	2	4	3	0	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:99452600G>A	uc001vnt.2	-	52	5958	c.5903C>T	c.(5902-5904)TCG>TTG	p.S1968L	DOCK9_uc001vnw.2_Missense_Mutation_p.S1967L|DOCK9_uc001vnq.2_Missense_Mutation_p.S515L|DOCK9_uc001vnr.2_Missense_Mutation_p.S597L|DOCK9_uc010tin.1_Missense_Mutation_p.S586L|DOCK9_uc001vns.2_Missense_Mutation_p.S503L|DOCK9_uc010tio.1_Missense_Mutation_p.S623L|DOCK9_uc010tip.1_Missense_Mutation_p.S664L	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1968	Potential.|DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CACCTCGGCCGAGGAGCACAG	0.612													11	21					0	0	0	0	A	99452600	A	A	99452600	3	1	194	1	0	0	0	0	1	0	0	0	4716	1059	37	1	326	1	DOCK9	13	99452600	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	87794	99452600	15717278	180	35677											
COL4A1	1282	broad.mit.edu	37	chr13	110814632	110814632	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtagagcaaagagtacccGtggtaaagaattttggtccc	13	9	11	8	2	0	3	0	0	0	3	1	3	1	3	2	2	2	4	2	2	6	5	rs149068853		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:110814632G>A	uc001vqw.3	-	48	4529	c.4407C>T	c.(4405-4407)CAC>CAT	p.H1469H	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1469	Collagen IV NC1.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AAGAGTACCCGTGGTAAAGAA	0.512													7	373					0	0	0	0	A	110814632	A	A	110814632	2	1	194	1	0	0	0	0	0	0	0	1	3704	1136	40	1		1	COL4A1	13	110814632	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	11362032	110814632	4355246	181	35678											
COL4A1	1282	broad.mit.edu	37	chr13	110828798	110828798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccattccaccaacagatcCttttggtcccggaagtcctg	8	10	8	15	1	0	1	0	0	0	1	4	2	4	2	6	2	1	0	6	2	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:110828798C>T	uc001vqw.3	-	36	3153	c.3031G>A	c.(3031-3033)GGA>AGA	p.G1011R	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1011	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCAACAGATCCTTTTGGTCCC	0.483													23	44					0	0	0	0	T	110828798	T	T	110828798	3	4	194	1	0	0	0	0	1	0	0	0	3704	690	24	4	2046	4	COL4A1	13	110828798	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	14166	110828798	4341080	182	35679											
OR4Q3	441669	broad.mit.edu	37	chr14	20216179	20216179	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacacctatgtggtagaggTgctggtgatagccaacagtg	10	9	15	7	0	0	2	0	1	0	1	0	3	0	3	2	4	3	2	2	4	4	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr14:20216179T>A	uc010tkt.1	+	1	593	c.593T>A	c.(592-594)GTG>GAG	p.V198E		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGGTAGAGGTGCTGGTGATA	0.493													25	36					0	0	0	0	A	20216179	A	A	20216179	3	1	194	1	0	0	0	0	1	0	0	0	11135	1696	59	5	595	5	OR4Q3	14	20216179	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08		20216179	87133361	183	35680											
METTL3	56339	broad.mit.edu	37	chr14	21969087	21969087	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtcggtctgcactggaatCacctccgacactctgtgtaa	9	10	10	12	2	3	0	1	0	2	0	5	3	4	1	2	2	1	2	2	2	2	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr14:21969087C>T	uc001wbc.2	-	5	1176	c.1084G>A	c.(1084-1086)GAT>AAT	p.D362N	METTL3_uc001wbb.2_Missense_Mutation_p.D207N|METTL3_uc010tlw.1_RNA	NM_019852	NP_062826	Q86U44	MTA70_HUMAN	methyltransferase like 3	362					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			pancreas(1)|skin(1)	2	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		GCACTGGAATCACCTCCGACA	0.507													12	8					0	0	0	0	T	21969087	T	T	21969087	3	4	194	1	0	0	0	0	1	0	0	0	9554	826	29	2	686	2	METTL3	14	21969087	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	1752908	21969087	85380453	184	35681											
PLEKHG3	26030	broad.mit.edu	37	chr14	65194605	65194605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acagccgggcagcggcagggCctgcacaccacaagctcagc	10	2	13	16	2	1	0	1	0	0	0	1	0	1	0	3	3	5	4	3	3	1	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr14:65194605C>T	uc001xho.1	+	2	525	c.256C>T	c.(256-258)CCT>TCT	p.P86S	PLEKHG3_uc001xhn.1_Missense_Mutation_p.P86S|PLEKHG3_uc001xhp.2_Missense_Mutation_p.P86S|PLEKHG3_uc010aqh.1_5'Flank	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	86					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		AGCGGCAGGGCCTGCACACCA	0.637													8	4					0	0	0	0	T	65194605	T	T	65194605	3	4	194	1	0	0	0	0	1	0	0	0	12125	739	26	4	258	4	PLEKHG3	14	65194605	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	43225518	65194605	42154935	185	35682											
OR4N4	283694	broad.mit.edu	37	chr15	22332432	22332432	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaaaaaaacaagattctaaCgtgacagaacttgttcttct	17	11	6	7	1	3	3	0	1	3	2	3	4	3	3	0	0	3	1	0	0	7	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:22332432C>T	uc001yuc.1	+	3	239	c.-742C>T	c.(-744--740)AACGT>AATGT		LOC727924_uc001ytz.1_Intron|LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		AAGATTCTAACGTGACAGAAC	0.328													4	26					0	0	0	0	T	22332432	T	T	22332432	1	4	194	1	0	0	0	0	0	0	0	0	11132	551	19	1		1	OR4N4	15	22332432	Translation_Start_Site	SNP	C	TCGA-CV-6935-01A-11D-1912-08		22332432	80198960	186	35683											
CYFIP1	23191	broad.mit.edu	37	chr15	22956494	22956494	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagacaaaagtggttccaaGaaaaccttgagaagtagcct	16	7	10	8	0	0	3	0	1	0	3	1	4	1	3	3	1	2	3	3	1	7	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:22956494G>C	uc001yus.2	+	16	1835	c.1731G>C	c.(1729-1731)AAG>AAC	p.K577N	CYFIP1_uc001yut.2_Missense_Mutation_p.K577N|CYFIP1_uc010aya.1_Missense_Mutation_p.K605N|CYFIP1_uc001yuu.2_Missense_Mutation_p.K146N	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	577					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GTGGTTCCAAGAAAACCTTGA	0.408													32	15					0	0	0	0	C	22956494	C	C	22956494	3	2	194	1	0	0	0	0	1	0	0	0	4154	933	33	2	2170	2	CYFIP1	15	22956494	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	624062	22956494	79574898	187	35684											
C15orf2	23742	broad.mit.edu	37	chr15	24923926	24923926	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgagggtcacaatgcaagtgCtttccccaatggcacagcaa	12	7	10	12	1	1	0	1	0	0	0	2	1	2	0	2	2	3	4	2	2	4	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:24923926C>G	uc001ywo.2	+	1	3386	c.2912C>G	c.(2911-2913)GCT>GGT	p.A971G		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	971					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AATGCAAGTGCTTTCCCCAAT	0.483													28	16					0	0	0	0	G	24923926	G	G	24923926	3	3	194	1	0	0	0	0	1	0	0	0	1790	797	28	4	2914	4	C15orf2	15	24923926	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	1967432	24923926	77607466	188	35685											
RYR3	6263	broad.mit.edu	37	chr15	33954863	33954863	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtgcagcggggcccacatccGagaccctgtaggggggtctg	6	6	17	12	2	1	1	0	0	1	1	2	2	2	1	3	5	2	2	3	5	1	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:33954863G>C	uc001zhi.2	+	35	5202	c.5132G>C	c.(5131-5133)CGA>CCA	p.R1711P	RYR3_uc010bar.2_Missense_Mutation_p.R1711P	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1711	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCCCACATCCGAGACCCTGTA	0.562													23	18					0	0	0	0	C	33954863	C	C	33954863	3	2	194	1	0	0	0	0	1	0	0	0	13835	1058	37	3	5270	3	RYR3	15	33954863	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	9030937	33954863	68576529	189	35686											
SLC24A5	283652	broad.mit.edu	37	chr15	48434437	48434437	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaatggctggaaactagaCagaaagttgggaatagtctg	14	10	12	5	0	2	2	1	0	1	2	2	4	2	4	0	3	1	2	0	3	6	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:48434437C>T	uc001zwe.2	+	9	1465	c.1392C>T	c.(1390-1392)GAC>GAT	p.D464D	SLC24A5_uc010bel.2_Silent_p.D404D|MYEF2_uc001zwg.3_3'UTR|MYEF2_uc001zwh.3_3'UTR|MYEF2_uc001zwi.3_3'UTR|MYEF2_uc001zwj.3_3'UTR|SLC24A5_uc001zwk.2_Silent_p.D95D	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	464	Extracellular (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		GGAAACTAGACAGAAAGTTGG	0.343													40	20					0	0	0	0	T	48434437	T	T	48434437	2	4	194	1	0	0	0	0	0	0	0	1	14533	477	17	4		4	SLC24A5	15	48434437	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	14479574	48434437	54096955	190	35687											
FBN1	2200	broad.mit.edu	37	chr15	48818391	48818391	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catttgcaaaagtaactgctGactgtgtttgtacattcacc	11	14	7	9	0	1	1	1	1	0	0	1	1	1	1	1	0	4	5	1	0	4	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:48818391G>A	uc001zwx.1	-	9	1252	c.924C>T	c.(922-924)GTC>GTT	p.V308V		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	308	EGF-like 5; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGTAACTGCTGACTGTGTTTG	0.403													50	11					0	0	0	0	A	48818391	A	A	48818391	2	1	194	1	0	0	0	0	0	0	0	1	5734	1277	45	2		2	FBN1	15	48818391	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	383954	48818391	53713001	191	35688											
SGK269	79834	broad.mit.edu	37	chr15	77474169	77474169	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgggtgatgggtgccttctCagggtctgggggaagctggt	5	11	19	6	0	2	1	1	1	2	0	3	2	2	2	1	6	2	1	1	6	1	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:77474169C>T	uc002bcm.2	-	3	408	c.100G>A	c.(100-102)GAG>AAG	p.E34K	SGK269_uc002bcn.2_Missense_Mutation_p.E34K	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	34					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		GGTGCCTTCTCAGGGTCTGGG	0.468													8	182					0	0	0	0	T	77474169	T	T	77474169	3	4	194	1	0	0	0	0	1	0	0	0	14276	835	29	2	5156	2	SGK269	15	77474169	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	28655778	77474169	25057223	192	35689											
BNC1	646	broad.mit.edu	37	chr15	83926817	83926817	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgcacggaaatgatcttCactactctccaatgcttcct	10	12	6	13	1	3	1	1	1	2	0	5	2	4	2	2	1	4	3	2	1	3	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:83926817C>T	uc002bjt.1	-	5	2450	c.2362G>A	c.(2362-2364)GAA>AAA	p.E788K	BNC1_uc010uos.1_Missense_Mutation_p.E776K	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	788					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AAATGATCTTCACTACTCTCC	0.458													36	63					0	0	0	0	T	83926817	T	T	83926817	3	4	194	1	0	0	0	0	1	0	0	0	1477	835	29	2	626	2	BNC1	15	83926817	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	6452648	83926817	18604575	193	35690											
AKAP13	11214	broad.mit.edu	37	chr15	86124699	86124699	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgccgttctaggtttgccaGtggctctacaggacaaagct	9	11	11	10	1	2	0	0	0	2	0	2	1	2	1	2	3	4	4	2	3	3	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:86124699G>A	uc002blv.1	+	7	3570	c.3400G>A	c.(3400-3402)GTG>ATG	p.V1134M	AKAP13_uc002blt.1_Missense_Mutation_p.V1134M|AKAP13_uc002blu.1_Missense_Mutation_p.V1134M|AKAP13_uc010bne.1_5'Flank	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1134					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						AGGTTTGCCAGTGGCTCTACA	0.507													64	19					0	0	0	0	A	86124699	A	A	86124699	3	1	194	1	0	0	0	0	1	0	0	0	449	1029	36	4	3422	4	AKAP13	15	86124699	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	2197882	86124699	16406693	194	35691											
LRRK1	79705	broad.mit.edu	37	chr15	101567909	101567909	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagcgccgcagccgggacGacgacgtgcagtacctgacg	9	3	15	14	7	0	1	0	1	0	0	0	4	0	2	3	1	5	4	3	1	1	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:101567909G>T	uc002bwr.2	+	19	2912	c.2593G>T	c.(2593-2595)GAC>TAC	p.D865Y	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	865					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CAGCCGGGACGACGACGTGCA	0.662													12	7					7.93312e-07	1.00149e-06	1	0	T	101567909	T	T	101567909	3	4	194	1	0	0	0	0	1	0	0	0	9082	1058	37	3	2663	3	LRRK1	15	101567909	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	15443210	101567909	963483	195	35692											
GRIN2A	2903	broad.mit.edu	37	chr16	10274094	10274094	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggggcagccccgccgcctGctcggggccccacagtgttc	4	5	14	18	3	0	0	0	0	0	0	2	0	0	0	6	4	2	3	6	4	0	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:10274094G>T	uc002czo.3	-	2	723	c.175C>A	c.(175-177)CAG>AAG	p.Q59K	GRIN2A_uc010uym.1_Missense_Mutation_p.Q59K|GRIN2A_uc002czr.3_Missense_Mutation_p.Q59K|GRIN2A_uc010buk.2_Missense_Mutation_p.Q59K	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	59	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCCGCCGCCTGCTCGGGGCCC	0.657													44	77					1.8453e-21	2.86867e-21	1	0	T	10274094	T	T	10274094	3	4	194	1	0	0	0	0	1	0	0	0	6818	1328	46	4	4267	4	GRIN2A	16	10274094	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08		10274094	80080659	196	35693											
ITPRIPL2	162073	broad.mit.edu	37	chr16	19127024	19127026	+	In_Frame_Del	DEL	TGC	-	-																															caagacagtgctgctggcagTgctgctgcgcaagggggccc																										TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:19127024_19127026delTGC	uc002dfu.3	+	1	1771_1773	c.1241_1243delTGC	c.(1240-1245)GTGCTG>GTG	p.L416del	ITPRIPL2_uc002dft.2_In_Frame_Del_p.L112del	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	416	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						CTGCTGGCAGTGCTGCTGCGCAA	0.655													---	---	---								-	19127026	-	-	19127024	7	5	194	1	0	1	0	1	0	0	0	0	7964	1696	59	0	1243	0	ITPRIPL2	16	19127024	In_Frame_Del	DEL	TGC	TCGA-CV-6935-01A-11D-1912-08	8852930	19127024	71227729	197	35694											
ARHGAP17	55114	broad.mit.edu	37	chr16	24980081	24980081	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcagcatctccacacgtCtccagcatcttcctttaaaa	10	13	3	15	1	4	0	1	0	4	0	8	0	5	0	3	0	2	2	3	0	2	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:24980081C>A	uc002dnb.2	-	5	378	c.285G>T	c.(283-285)GAG>GAT	p.E95D	ARHGAP17_uc002dnc.2_Missense_Mutation_p.E95D|ARHGAP17_uc010vcf.1_Intron|ARHGAP17_uc002dnf.2_Missense_Mutation_p.E3D|ARHGAP17_uc002dng.1_Missense_Mutation_p.E95D	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	95	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CTCCACACGTCTCCAGCATCT	0.507													27	38					2.41591e-17	3.55398e-17	1	0	A	24980081	A	A	24980081	3	1	194	1	0	0	0	0	1	0	0	0	867	912	32	2	2424	2	ARHGAP17	16	24980081	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	5853057	24980081	65374672	198	35695											
RABEP2	79874	broad.mit.edu	37	chr16	28917494	28917494	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccctcgcctcttgccgcgtGcagcacagcagctgctgcag	5	7	12	17	3	1	0	0	0	1	0	2	0	1	0	3	0	7	6	3	0	0	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:28917494G>A	uc002drq.2	-	9	1317	c.1269C>T	c.(1267-1269)TGC>TGT	p.C423C	uc010vct.1_Intron|RABEP2_uc010vdf.1_Silent_p.C352C|RABEP2_uc010byn.2_Silent_p.C391C	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	423	Potential.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						CTTGCCGCGTGCAGCACAGCA	0.716													7	10					0	0	0	0	A	28917494	A	A	28917494	2	1	194	1	0	0	0	0	0	0	0	1	13027	1311	46	4		4	RABEP2	16	28917494	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	3937413	28917494	61437259	199	35696											
SEZ6L2	26470	broad.mit.edu	37	chr16	29888756	29888756	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggaccgtccccgtcgaacAgcgtcagcatgtccccttcc	6	8	10	17	4	1	0	1	0	0	0	5	2	4	1	6	1	3	1	6	1	1	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:29888756A>T	uc002duq.3	-	11	1985	c.1745T>A	c.(1744-1746)CTG>CAG	p.L582Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.L512Q|SEZ6L2_uc002dur.3_Missense_Mutation_p.L512Q|SEZ6L2_uc002dus.3_Missense_Mutation_p.L468Q|SEZ6L2_uc010vec.1_Missense_Mutation_p.L582Q|SEZ6L2_uc010ved.1_Missense_Mutation_p.L538Q	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	582	CUB 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CCCGTCGAACAGCGTCAGCAT	0.692													10	26					0	0	0	0	T	29888756	T	T	29888756	3	4	194	1	0	0	0	0	1	0	0	0	14209	188	7	5	1058	5	SEZ6L2	16	29888756	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	971262	29888756	60465997	200	35697											
VKORC1	79001	broad.mit.edu	37	chr16	31105904	31105904	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagaagacgcgcgaacagctGatggcggtgcccacgtcgca	10	4	15	12	6	0	3	0	1	0	2	1	5	0	3	1	2	3	2	1	2	2	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:31105904G>A	uc002eas.2	-	1	373	c.147C>T	c.(145-147)ATC>ATT	p.I49I	PRSS53_uc002ear.2_5'UTR|VKORC1_uc002eat.2_Silent_p.I49I|VKORC1_uc002eau.2_Silent_p.I49I	NM_024006	NP_076869	Q9BQB6	VKOR1_HUMAN	vitamin K epoxide reductase complex, subunit 1	49	Cytoplasmic (Potential).				peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane	vitamin-K-epoxide reductase (warfarin-sensitive) activity				0					Acenocoumarol(DB01418)|Dicumarol(DB00266)|Menadione(DB00170)|Phenindione(DB00498)|Phenprocoumon(DB00946)|Warfarin(DB00682)	GCGAACAGCTGATGGCGGTGC	0.682													12	11					0	0	0	0	A	31105904	A	A	31105904	2	1	194	1	0	0	0	0	0	0	0	1	17240	1280	45	2		2	VKORC1	16	31105904	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	1217148	31105904	59248849	201	35698											
CMTM1	113540	broad.mit.edu	37	chr16	66603837	66603837	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcctgtttcttttattgcAgagtcttatcttaggagcat	9	18	7	7	0	3	1	0	0	3	1	4	2	4	2	1	1	2	3	1	1	4	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:66603837A>T	uc002epi.3	+	2	205	c.82_splice	c.e2-2	p.S28_splice	CMTM1_uc002epb.3_Splice_Site|CMTM1_uc002epc.3_Splice_Site|CMTM1_uc002epd.3_Intron|CMTM1_uc002epe.3_Intron|CMTM1_uc002epf.3_Intron|CMTM1_uc002epg.3_Intron|CMTM1_uc002eph.3_Splice_Site_p.S28_splice|CMTM1_uc002epl.3_Intron|CMTM1_uc002epj.3_Intron|CMTM1_uc002epk.3_Intron|CMTM1_uc002epa.3_Intron|CMTM1_uc002epn.3_Splice_Site_p.S145_splice|CMTM1_uc002epo.3_Splice_Site|CMTM1_uc002epp.3_Splice_Site|CMTM1_uc002epq.3_Splice_Site|CMTM1_uc010cds.2_Splice_Site|CMTM1_uc002epr.3_Splice_Site_p.S145_splice|CMTM1_uc002epm.3_Splice_Site|CMTM1_uc002eps.2_5'Flank	NM_181269	NP_851786	Q8IZ96	CKLF1_HUMAN	chemokine-like factor superfamily 1 isoform 1						chemotaxis	extracellular space|integral to membrane	cytokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		CTTTTATTGCAGAGTCTTATC	0.323													31	57					0	0	0	0	T	66603837	T	T	66603837	5	4	194	1	0	0	0	0	0	0	1	0	3597	202	7	5	437	5	CMTM1	16	66603837	Splice_Site	SNP	A	TCGA-CV-6935-01A-11D-1912-08	35497933	66603837	23750916	202	35699											
FUK	197258	broad.mit.edu	37	chr16	70499039	70499039	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	actcctgcaggtggtcacatCcgatgtcctgcactcggcct	6	10	10	15	2	1	0	1	0	0	0	5	1	4	0	4	3	2	2	4	3	0	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:70499039C>T	uc002eyy.2	+	4	303	c.245C>T	c.(244-246)TCC>TTC	p.S82F	FUK_uc010vmb.1_Intron|FUK_uc010cft.2_Missense_Mutation_p.S114F|FUK_uc002eyz.2_Intron	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	82						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				GTGGTCACATCCGATGTCCTG	0.572													11	14					0	0	0	0	T	70499039	T	T	70499039	3	4	194	1	0	0	0	0	1	0	0	0	6130	855	30	2	255	2	FUK	16	70499039	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	3895202	70499039	19855714	203	35700											
PMFBP1	83449	broad.mit.edu	37	chr16	72188112	72188112	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggttaatctgtctatacctCatcttctttcagtttgcagt	7	19	6	9	0	6	0	2	0	4	0	6	0	6	0	1	1	2	3	1	1	3	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:72188112C>T	uc002fcc.3	-	4	584	c.412G>A	c.(412-414)GAG>AAG	p.E138K	PMFBP1_uc002fcd.2_Missense_Mutation_p.E138K|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_5'UTR	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	138										ovary(2)	2		Ovarian(137;0.179)				GTCTATACCTCATCTTCTTTC	0.463													42	68					0	0	0	0	T	72188112	T	T	72188112	3	4	194	1	0	0	0	0	1	0	0	0	12189	835	29	2	2743	2	PMFBP1	16	72188112	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	1689073	72188112	18166641	204	35701											
IRF8	3394	broad.mit.edu	37	chr16	85946795	85946795	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttccccgccggaggcctGtcggagtcagctccttccag	4	8	11	18	3	1	0	1	0	0	0	5	2	4	2	7	3	1	1	7	3	0	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:85946795G>T	uc002fjh.2	+	5	563	c.506G>T	c.(505-507)TGT>TTT	p.C169F	IRF8_uc010chp.2_Intron	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	169					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				CCGGAGGCCTGTCGGAGTCAG	0.617													48	88					6.17242e-35	1.01731e-34	1	0	T	85946795	T	T	85946795	3	4	194	1	0	0	0	0	1	0	0	0	7875	1377	48	4	520	4	IRF8	16	85946795	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	13758683	85946795	4407958	205	35702											
TP53	7157	broad.mit.edu	37	chr17	7577557	7577557	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggttcatgccgcccatgcAggaactgttacacatgtagt	9	10	10	12	2	1	0	1	0	0	0	1	1	1	1	3	2	4	4	3	2	3	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:7577557A>T	uc002gim.2	-	7	918	c.724T>A	c.(724-726)TGC>AGC	p.C242S	TP53_uc002gig.1_Missense_Mutation_p.C242S|TP53_uc002gih.2_Missense_Mutation_p.C242S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C110S|TP53_uc010cng.1_Missense_Mutation_p.C110S|TP53_uc002gii.1_Missense_Mutation_p.C110S|TP53_uc010cnh.1_Missense_Mutation_p.C242S|TP53_uc010cni.1_Missense_Mutation_p.C242S|TP53_uc002gij.2_Missense_Mutation_p.C242S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C149S|TP53_uc002gio.2_Missense_Mutation_p.C110S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	242	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).	Zinc.	C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(63)|p.C242Y(37)|p.C242S(25)|p.C242fs*5(16)|p.C242R(11)|p.C242W(7)|p.0?(7)|p.N239_C242delNSSC(3)|p.C242*(3)|p.S241del(2)|p.C242C(2)|p.C242G(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241_G245delSCMGG(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGCCCATGCAGGAACTGTTA	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			67	22					0	0	0	0	T	7577557	T	T	7577557	3	4	194	1	0	0	0	0	1	0	0	0	16448	188	7	5	566	5	TP53	17	7577557	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08		7577557	73617653	206	35703											
MYH4	4622	broad.mit.edu	37	chr17	10351339	10351339	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggttcctctttagctgatcGagttcttcatctttttcagc	5	19	7	10	1	5	1	2	1	3	0	7	2	6	1	1	1	2	3	1	1	1	7			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:10351339G>A	uc002gmn.2	-	34	4872	c.4761C>T	c.(4759-4761)CTC>CTT	p.L1587L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1587	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TTAGCTGATCGAGTTCTTCAT	0.418													6	155					0	0	0	0	A	10351339	A	A	10351339	2	1	194	1	0	0	0	0	0	0	0	1	10090	1045	37	1		1	MYH4	17	10351339	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	2773782	10351339	70843871	207	35704											
COX10	1352	broad.mit.edu	37	chr17	13977709	13977709	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccctcacaagttcttacAtcttctcaggaatgtcaata	11	13	4	13	0	5	0	3	0	3	0	7	1	6	1	2	1	1	1	2	1	5	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:13977709A>G	uc002gof.3	+	2	317	c.113A>G	c.(112-114)CAT>CGT	p.H38R	COX10_uc010vvs.1_5'UTR|COX10_uc010vvt.1_5'UTR	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	38					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		AAGTTCTTACATCTTCTCAGG	0.403													63	95					0	0	0	0	G	13977709	G	G	13977709	3	3	194	1	0	0	0	0	1	0	0	0	3777	217	8	5	119	5	COX10	17	13977709	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	3626370	13977709	67217501	208	35705											
LYZL6	57151	broad.mit.edu	37	chr17	34266465	34266465	+	Translation_Start_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatctggagagggcagccaGgtttccttactcactcactg	9	10	11	11	0	3	1	2	0	1	1	4	3	4	1	2	3	2	2	2	3	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:34266465G>T	uc002hkj.1	-	1	46	c.-104C>A	c.(-106--102)ACCTG>ACATG		LYZL6_uc002hkk.1_Intron	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor						cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGGCAGCCAGGTTTCCTTAC	0.418													8	23					0.00307968	0.00367908	1	0	T	34266465	T	T	34266465	1	4	194	1	0	0	0	0	0	0	0	0	9185	1015	35	4		4	LYZL6	17	34266465	Translation_Start_Site	SNP	G	TCGA-CV-6935-01A-11D-1912-08	20288756	34266465	46928745	209	35706											
THRA	7067	broad.mit.edu	37	chr17	38249328	38249328	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcggcagaaggccggcCgggcgggtcactgggcgtcc	5	3	20	13	5	1	1	1	0	0	1	2	1	2	1	3	7	1	2	3	7	1	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:38249328C>A	uc002htw.2	+	10	1649	c.1166C>A	c.(1165-1167)CCG>CAG	p.P389Q	THRA_uc002htx.2_Intron|NR1D1_uc002htz.1_3'UTR|NR1D1_uc010cwq.1_RNA	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	389					negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	GAAGGCCGGCCGGGCGGGTCA	0.552													31	57					4.4194e-11	5.9595e-11	1	0	A	38249328	A	A	38249328	3	1	194	1	0	0	0	0	1	0	0	0	15939	652	23	3	1323	3	THRA	17	38249328	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	3982863	38249328	42945882	210	35707											
RPS6KB1	6198	broad.mit.edu	37	chr17	58024140	58024140	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggccagagcacctgcgtatGaatctatgacagagcaatgc	12	7	11	11	2	1	4	0	2	1	2	1	4	1	4	2	1	4	3	2	1	4	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:58024140G>C	uc002ixy.2	+	15	1672	c.1569G>C	c.(1567-1569)ATG>ATC	p.M523I	RPS6KB1_uc010ddj.1_Intron|RPS6KB1_uc010wom.1_Missense_Mutation_p.M470I|RPS6KB1_uc010won.1_Missense_Mutation_p.M500I|RPS6KB1_uc010woo.1_Missense_Mutation_p.M458I|RPS6KB1_uc002ixz.2_RNA	NM_003161	NP_003152	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide	523	Autoinhibitory domain.				apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			large_intestine(1)	1	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			ACCTGCGTATGAATCTATGAC	0.463													31	45					0	0	0	0	C	58024140	C	C	58024140	3	2	194	1	0	0	0	0	1	0	0	0	13721	1290	45	2	1627	2	RPS6KB1	17	58024140	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	19774812	58024140	23171070	211	35708											
RECQL5	9400	broad.mit.edu	37	chr17	73657115	73657115	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcctccatccagtcgttCtgcaccagcgttctttcaga	6	14	6	15	2	4	1	1	0	3	1	8	1	6	1	4	0	2	3	4	0	0	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:73657115C>G	uc010dgl.2	-	6	1062	c.906G>C	c.(904-906)CAG>CAC	p.Q302H	RECQL5_uc010dgk.2_Missense_Mutation_p.Q275H|RECQL5_uc002jpb.1_Missense_Mutation_p.Q302H|RECQL5_uc002joz.3_Missense_Mutation_p.Q302H|RECQL5_uc002jpa.3_Missense_Mutation_p.Q302H	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	302	Helicase C-terminal.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TCCAGTCGTTCTGCACCAGCG	0.453								Other_identified_genes_with_known_or_suspected_DNA_repair_function					14	110					0	0	0	0	G	73657115	G	G	73657115	3	3	194	1	0	0	0	0	1	0	0	0	13268	912	32	2	2216	2	RECQL5	17	73657115	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	15632975	73657115	7538095	212	35709											
GAA	2548	broad.mit.edu	37	chr17	78081647	78081647	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctttctacctggcgctggagGacggcgggtcggcacacggg	5	7	17	12	5	1	0	0	0	1	0	2	2	1	2	1	7	1	2	1	7	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:78081647G>A	uc002jxo.2	+	6	1089	c.907G>A	c.(907-909)GAC>AAC	p.D303N	GAA_uc002jxp.2_Missense_Mutation_p.D303N|GAA_uc002jxq.2_Missense_Mutation_p.D303N	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	303					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GGCGCTGGAGGACGGCGGGTC	0.677													3	25					0	0	0	0	A	78081647	A	A	78081647	3	1	194	1	0	0	0	0	1	0	0	0	6181	1174	41	2	921	2	GAA	17	78081647	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	4424532	78081647	3113563	213	35710											
LAMA1	284217	broad.mit.edu	37	chr18	7079974	7079974	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggttctgggctcacctacCtgtcttaagtccagagtgat	8	13	10	10	0	3	2	1	1	2	1	4	2	4	2	3	2	1	2	3	2	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr18:7079974C>G	uc002knm.2	-	3	439	c.345G>C	c.(343-345)CAG>CAC	p.Q115H	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	115	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTCACCTACCTGTCTTAAGT	0.468													9	59					0	0	0	0	G	7079974	G	G	7079974	3	3	194	1	0	0	0	0	1	0	0	0	8645	695	24	4	9126	4	LAMA1	18	7079974	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08		7079974	70997274	214	35711											
C18orf1	753	broad.mit.edu	37	chr18	13621229	13621229	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacgcggtccttcatcaacCgcccgaaccagagccggagg	9	4	11	17	5	2	1	2	0	0	1	3	3	3	2	6	3	3	0	6	3	2	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr18:13621229C>T	uc002ksa.2	+	5	963	c.295C>T	c.(295-297)CGC>TGC	p.R99C	C18orf1_uc002ksb.2_Missense_Mutation_p.R99C|C18orf1_uc002kse.2_Missense_Mutation_p.R62C|C18orf1_uc002ksf.2_Missense_Mutation_p.R62C|C18orf1_uc002ksg.1_Missense_Mutation_p.R22C|C18orf1_uc002ksh.1_Missense_Mutation_p.R41C|C18orf1_uc002ksi.1_Missense_Mutation_p.R41C	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	99	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		CTTCATCAACCGCCCGAACCA	0.637													102	29					0	0	0	0	T	13621229	T	T	13621229	3	4	194	1	0	0	0	0	1	0	0	0	1903	652	23	1	386	1	C18orf1	18	13621229	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	6541255	13621229	64456019	215	35712											
HRH4	59340	broad.mit.edu	37	chr18	22056718	22056718	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtttcttctaggtgtcttAtagaactcaacatactgggg	9	15	10	7	0	4	1	1	0	3	1	4	1	4	1	0	4	3	1	0	4	6	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr18:22056718A>T	uc002kvi.2	+	3	465	c.365A>T	c.(364-366)TAT>TTT	p.Y122F	HRH4_uc010xbd.1_Missense_Mutation_p.L67F|HRH4_uc010dlx.2_Intron	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	122	Cytoplasmic (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TAGGTGTCTTATAGAACTCAA	0.378													7	42					0	0	0	0	T	22056718	T	T	22056718	3	4	194	1	0	0	0	0	1	0	0	0	7397	449	16	5	375	5	HRH4	18	22056718	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	8435489	22056718	56020530	216	35713											
ZNF521	25925	broad.mit.edu	37	chr18	22804737	22804737	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtctgaactgcagaccCattccctgtcttttgcatgt	6	15	9	11	0	2	2	0	1	2	1	3	2	3	2	2	1	3	2	2	1	1	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr18:22804737C>A	uc002kvk.2	-	4	3392	c.3145G>T	c.(3145-3147)GGG>TGG	p.G1049W	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.G1049W|ZNF521_uc002kvl.2_Missense_Mutation_p.G829W	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1049					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					ACTGCAGACCCATTCCCTGTC	0.522			T	PAX5	ALL								19	20					8.00594e-06	9.93071e-06	1	0	A	22804737	A	A	22804737	3	1	194	1	0	0	0	0	1	0	0	0	18032	594	21	4	810	4	ZNF521	18	22804737	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	748019	22804737	55272511	217	35714											
CD226	10666	broad.mit.edu	37	chr18	67614187	67614187	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atggctatggaatcctgctgGgtcccgatcttgaaccactc	8	11	10	12	1	1	1	0	1	1	0	4	3	3	2	3	3	2	2	3	3	3	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr18:67614187G>A	uc010dqo.2	-	2	612	c.165C>T	c.(163-165)ACC>ACT	p.T55T	CD226_uc002lkm.3_Silent_p.T55T	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	55	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				AATCCTGCTGGGTCCCGATCT	0.463													21	15					0	0	0	0	A	67614187	A	A	67614187	2	1	194	1	0	0	0	0	0	0	0	1	3001	1219	43	4		4	CD226	18	67614187	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	44809450	67614187	10463061	218	35715											
SAFB2	9667	broad.mit.edu	37	chr19	5598876	5598876	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatttatccatcacgaccgtCcgctccattcctctgcttcc	6	13	5	17	3	2	0	1	0	1	0	7	2	7	0	6	0	1	2	6	0	1	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:5598876C>G	uc002mcd.2	-	13	1922	c.1710G>C	c.(1708-1710)CGG>CGC	p.R570R		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TCACGACCGTCCGCTCCATTC	0.507													26	48					0	0	0	0	G	5598876	G	G	5598876	2	3	194	1	0	0	0	0	0	0	0	1	13872	842	30	2		2	SAFB2	19	5598876	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08		5598876	53530107	219	35716											
DUS3L	56931	broad.mit.edu	37	chr19	5786796	5786796	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctggcggcctgcacgcactCctcgatgtactgccagtcgg	5	8	13	15	4	0	0	0	0	0	0	3	1	1	0	3	3	3	4	3	3	1	1			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:5786796C>T	uc002mdc.2	-	9	1547	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	PRR22_uc002mdb.1_5'Flank|PRR22_uc010xiv.1_5'Flank|DUS3L_uc002mdd.2_Missense_Mutation_p.E242K|DUS3L_uc010duk.2_Missense_Mutation_p.E149K	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	484					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0						TGCACGCACTCCTCGATGTAC	0.612													19	33					0	0	0	0	T	5786796	T	T	5786796	3	4	194	1	0	0	0	0	1	0	0	0	4829	864	30	2	522	2	DUS3L	19	5786796	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	187920	5786796	53342187	220	35717											
MUC16	94025	broad.mit.edu	37	chr19	9000496	9000496	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttctagagccagggtgatgCatgttctcctcataccgcag	8	12	10	11	1	3	2	1	1	2	1	4	2	3	2	3	1	3	3	3	1	2	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:9000496C>A	uc002mkp.2	-	54	40692	c.40488G>T	c.(40486-40488)ATG>ATT	p.M13496I	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.M313I|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13498	SEA 10.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGGGTGATGCATGTTCTCCT	0.478													33	66					9.65021e-13	1.33676e-12	1	0	A	9000496	A	A	9000496	3	1	194	1	0	0	0	0	1	0	0	0	10026	710	25	4	3159	4	MUC16	19	9000496	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	3213700	9000496	50128487	221	35718											
ZNF560	147741	broad.mit.edu	37	chr19	9577562	9577562	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgaaaggaatttccacatgcGttacattcagaggtcttctc	11	12	8	10	2	3	1	1	0	2	1	5	3	4	2	1	2	2	1	1	2	3	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:9577562G>A	uc002mlp.1	-	10	2271	c.2061C>T	c.(2059-2061)AAC>AAT	p.N687N	ZNF560_uc010dwr.1_Silent_p.N581N	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	687					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						TTCCACATGCGTTACATTCAG	0.373													69	111					0	0	0	0	A	9577562	A	A	9577562	2	1	194	1	0	0	0	0	0	0	0	1	18058	1136	40	1		1	ZNF560	19	9577562	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	577066	9577562	49551421	222	35719											
PPAN-P2RY11	692312	broad.mit.edu	37	chr19	10221511	10221511	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgatgacatcgagtatttCtgccaggcggtgggcgaggc	8	9	16	8	3	1	2	0	2	1	0	2	5	1	2	1	4	1	1	1	4	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:10221511C>T	uc002mna.2	+	11	1170	c.1170C>T	c.(1168-1170)TTC>TTT	p.F390F	PPAN-P2RY11_uc010xla.1_Silent_p.F390F|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Silent_p.F390F|PPAN_uc002mnb.1_Silent_p.F337F	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	390					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TCGAGTATTTCTGCCAGGCGG	0.607													67	140					0	0	0	0	T	10221511	T	T	10221511	2	4	194	1	0	0	0	0	0	0	0	1	12344	912	32	2		2	PPAN-P2RY11	19	10221511	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	643949	10221511	48907472	223	35720											
KRI1	65095	broad.mit.edu	37	chr19	10665770	10665770	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcactgcttactcttctcGgcagagtgacttgaagacct	9	11	9	12	1	2	4	0	2	2	2	3	4	2	4	1	1	3	3	1	1	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:10665770G>C	uc002moy.1	-	18	1801	c.1792C>G	c.(1792-1794)CGA>GGA	p.R598G	KRI1_uc002mow.1_Missense_Mutation_p.R217G|KRI1_uc002mox.1_Missense_Mutation_p.R594G	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	598										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			tactcttctCGGCAGAGTGAC	0.303													25	39					0	0	0	0	C	10665770	C	C	10665770	3	2	194	1	0	0	0	0	1	0	0	0	8483	1124	39	3	345	3	KRI1	19	10665770	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	444259	10665770	48463213	224	35721											
ZNF878	729747	broad.mit.edu	37	chr19	12155285	12155285	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accacatagcttacactcatAgggtttctctccagtgtgtt	9	14	7	11	0	2	0	1	0	1	0	4	0	3	0	2	1	2	3	2	1	3	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:12155285A>G	uc002mta.1	-	5	1072	c.1072T>C	c.(1072-1074)TAT>CAT	p.Y358H		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	311	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TTACACTCATAGGGTTTCTCT	0.403													33	74					0	0	0	0	G	12155285	G	G	12155285	3	3	194	1	0	0	0	0	1	0	0	0	18263	420	15	5	668	5	ZNF878	19	12155285	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	1489515	12155285	46973698	225	35722											
NANOS3	342977	broad.mit.edu	37	chr19	13988559	13988561	+	In_Frame_Del	DEL	GAG	-	-																															acaggacacaggccaccgccGaggaggaggaggaggagcag																										TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:13988559_13988561delGAG	uc002mxj.3	+	1	610_612	c.497_499delGAG	c.(496-501)CGAGGA>CGA	p.G171del		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3	152					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GGCCACCGCCGAGGAGGAGGAGG	0.645													---	---	---								-	13988561	-	-	13988559	7	5	194	1	0	1	0	1	0	0	0	0	10206	1058	37	0	499	0	NANOS3	19	13988559	In_Frame_Del	DEL	GAG	TCGA-CV-6935-01A-11D-1912-08	1833274	13988559	45140424	226	35723											
CYP4F22	126410	broad.mit.edu	37	chr19	15651373	15651373	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actaccgctcggcggatgggCggaggttccggcaggcctgt	5	7	17	12	5	0	0	0	0	0	0	2	2	1	2	3	7	1	3	3	7	1	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:15651373C>T	uc002nbh.3	+	8	951	c.784C>T	c.(784-786)CGG>TGG	p.R262W		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	262						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						GGCGGATGGGCGGAGGTTCCG	0.607													29	90					0	0	0	0	T	15651373	T	T	15651373	3	4	194	1	0	0	0	0	1	0	0	0	4206	759	27	1	806	1	CYP4F22	19	15651373	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	1662814	15651373	43477610	227	35724											
UNC13A	23025	broad.mit.edu	37	chr19	17728564	17728564	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagcaggtcggtggcctgcGtgtagagcgacagggcatag	8	8	17	8	3	0	1	0	0	0	1	1	2	0	1	1	4	3	3	1	4	3	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:17728564G>A	uc002nhd.2	-	40	4769	c.4769C>T	c.(4768-4770)ACG>ATG	p.T1590M		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1502	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GGTGGCCTGCGTGTAGAGCGA	0.607													50	72					0	0	0	0	A	17728564	A	A	17728564	3	1	194	1	0	0	0	0	1	0	0	0	17052	1145	40	1	622	1	UNC13A	19	17728564	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	2077191	17728564	41400419	228	35725											
DYRK1B	9149	broad.mit.edu	37	chr19	40321360	40321360	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagagcttacgcagcggggCtgaggttgcatcccggaagg	9	6	17	9	3	0	2	0	1	0	1	1	4	1	3	1	5	4	5	1	5	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:40321360C>T	uc002omj.2	-	3	407	c.127G>A	c.(127-129)GCC>ACC	p.A43T	DYRK1B_uc002omi.2_Missense_Mutation_p.A43T|DYRK1B_uc002omk.2_Missense_Mutation_p.A43T|DYRK1B_uc002oml.2_Missense_Mutation_p.A43T	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	43					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CGCAGCGGGGCTGAGGTTGCA	0.642													30	42					0	0	0	0	T	40321360	T	T	40321360	3	4	194	1	0	0	0	0	1	0	0	0	4877	797	28	4	1798	4	DYRK1B	19	40321360	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	22592796	40321360	18807623	229	35726											
ZNF226	7769	broad.mit.edu	37	chr19	44680226	44680226	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctccagctttgatcttcatCagcagttacaatcaggagag	11	12	8	10	0	5	2	3	1	2	1	6	3	5	2	1	1	3	3	1	1	2	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:44680226C>T	uc002oyp.2	+	6	955	c.811C>T	c.(811-813)CAG>TAG	p.Q271*	ZNF226_uc002oyq.2_Nonsense_Mutation_p.Q154*|ZNF226_uc002oyr.2_Nonsense_Mutation_p.Q154*|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Nonsense_Mutation_p.Q271*|ZNF226_uc002oyt.2_Nonsense_Mutation_p.Q271*	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	271	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TGATCTTCATCAGCAGTTACA	0.423													23	42					0	0	0	0	T	44680226	T	T	44680226	4	4	194	1	0	0	0	0	0	1	0	0	17847	827	29	2	879	2	ZNF226	19	44680226	Nonsense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	4358866	44680226	14448757	230	35727											
ZNF233	353355	broad.mit.edu	37	chr19	44778658	44778658	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttcatcagaggatccacacGggagagaaaccctataaatg	15	7	10	9	1	2	2	2	0	0	2	3	5	3	4	2	2	1	1	2	2	4	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:44778658G>T	uc002oyz.1	+	5	1972	c.1845G>T	c.(1843-1845)ACG>ACT	p.T615T	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Silent_p.T430T	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	615					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				GGATCCACACGGGAGAGAAAC	0.438													38	56					1.06647e-15	1.54335e-15	1	0	T	44778658	T	T	44778658	2	4	194	1	0	0	0	0	0	0	0	1	17853	1103	39	3		3	ZNF233	19	44778658	Silent	SNP	G	TCGA-CV-6935-01A-11D-1912-08	98432	44778658	14350325	231	35728											
ZFP112	7771	broad.mit.edu	37	chr19	44832694	44832694	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttctctcctgtgtggactCtctgatgaacattcagaact	8	15	8	10	0	3	3	1	2	2	1	6	4	4	4	1	1	2	1	1	1	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:44832694C>G	uc010ejj.2	-	5	1747	c.1634G>C	c.(1633-1635)AGA>ACA	p.R545T	ZFP112_uc002ozc.3_Missense_Mutation_p.R539T|ZFP112_uc010xwy.1_Missense_Mutation_p.R562T|ZFP112_uc010xwz.1_Missense_Mutation_p.R544T	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	545	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TGTGTGGACTCTCTGATGAAC	0.423													61	101					0	0	0	0	G	44832694	G	G	44832694	3	3	194	1	0	0	0	0	1	0	0	0	17705	913	32	2	1111	2	ZFP112	19	44832694	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	54036	44832694	14296289	232	35729											
FCAR	2204	broad.mit.edu	37	chr19	55396680	55396680	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctttcatatctgccaaatCgagtcctgtgattcccttgg	7	14	8	12	1	2	1	1	1	1	0	5	2	4	1	4	1	1	0	4	1	2	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:55396680C>A	uc002qhr.1	+	3	301	c.104C>A	c.(103-105)TCG>TAG	p.S35*	FCAR_uc002qhq.2_Nonsense_Mutation_p.S35*|FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Nonsense_Mutation_p.S8*|FCAR_uc010esi.1_Nonsense_Mutation_p.S8*|FCAR_uc002qhu.1_Nonsense_Mutation_p.S35*|FCAR_uc002qhv.1_Nonsense_Mutation_p.S35*|FCAR_uc002qhw.1_Nonsense_Mutation_p.S23*|FCAR_uc002qhx.1_Nonsense_Mutation_p.S23*|FCAR_uc002qhy.1_Nonsense_Mutation_p.S23*|FCAR_uc002qhz.1_Nonsense_Mutation_p.S23*|FCAR_uc002qia.1_Intron	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	35	Extracellular (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		TCTGCCAAATCGAGTCCTGTG	0.498													22	34					3.62473e-10	4.81494e-10	1	0	A	55396680	A	A	55396680	4	1	194	1	0	0	0	0	0	1	0	0	5805	893	31	3	114	3	FCAR	19	55396680	Nonsense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	10563986	55396680	3732303	233	35730											
ZIM3	114026	broad.mit.edu	37	chr19	57646307	57646307	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatctggagtgaattcttttCtggtgcctaacaaggtatga	10	15	10	6	0	3	2	0	2	3	0	3	3	3	3	1	3	2	1	1	3	5	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:57646307C>T	uc002qnz.1	-	5	1784	c.1398G>A	c.(1396-1398)CAG>CAA	p.Q466Q		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	466	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAATTCTTTTCTGGTGCCTAA	0.428													49	70					0	0	0	0	T	57646307	T	T	57646307	2	4	194	1	0	0	0	0	0	0	0	1	17752	912	32	2		2	ZIM3	19	57646307	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	2249627	57646307	1482676	234	35731											
ZNF776	284309	broad.mit.edu	37	chr19	58265188	58265188	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtccttcaccagagacttctCcctagagaaggaccttatgt	10	11	8	12	0	2	2	1	0	1	2	4	5	3	3	4	1	0	0	4	1	3	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:58265188C>A	uc002qpx.2	+	3	913	c.690C>A	c.(688-690)CTC>CTA	p.L230L	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Silent_p.L230L	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	230	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		AGAGACTTCTCCCTAGAGAAG	0.418													38	69					1.04594e-18	1.57112e-18	1	0	A	58265188	A	A	58265188	2	1	194	1	0	0	0	0	0	0	0	1	18216	842	30	2		2	ZNF776	19	58265188	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	618881	58265188	863795	235	35732											
HAO1	54363	broad.mit.edu	37	chr20	7895010	7895010	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagcttccgccacttcttCaattgaggaggtggcccagg	8	9	11	13	1	2	1	1	1	1	0	3	2	3	2	4	4	1	1	4	4	1	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr20:7895010C>T	uc002wmw.1	-	3	370	c.346G>A	c.(346-348)GAA>AAA	p.E116K	HAO1_uc010gbu.2_Missense_Mutation_p.E116K	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	116	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						GCCACTTCTTCAATTGAGGAG	0.532													14	36					0	0	0	0	T	7895010	T	T	7895010	3	4	194	1	0	0	0	0	1	0	0	0	6990	835	29	2	790	2	HAO1	20	7895010	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08		7895010	55130510	236	35733											
KRTAP27-1	643812	broad.mit.edu	37	chr21	31709388	31709388	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tactaggcaattgagaaccaCcagtaacacagcaagttggt	15	8	9	9	0	0	1	0	1	0	1	0	2	0	1	2	2	4	4	2	2	6	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:31709388C>A	uc002ynx.1	-	1	625	c.599G>T	c.(598-600)GGT>GTT	p.G200V		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	200						intermediate filament				ovary(2)	2						TTGAGAACCACCAGTAACACA	0.408													14	29					0.000219431	0.000266613	1	0	A	31709388	A	A	31709388	3	1	194	1	0	0	0	0	1	0	0	0	8584	507	18	4	28	4	KRTAP27-1	21	31709388	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08		31709388	16420507	237	35734											
KRTAP11-1	337880	broad.mit.edu	37	chr21	32253706	32253706	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggagccaagagccagtctgGaaggaactgggcaaacagat	15	4	14	8	0	1	2	0	0	1	2	1	5	1	5	2	4	4	1	2	4	4	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:32253706G>T	uc002yov.2	-	1	169	c.138C>A	c.(136-138)TTC>TTA	p.F46L		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	46						keratin filament	structural molecule activity			pancreas(1)	1						AGCCAGTCTGGAAGGAACTGG	0.582													24	39					6.21321e-17	9.06518e-17	1	0	T	32253706	T	T	32253706	3	4	194	1	0	0	0	0	1	0	0	0	8556	1165	41	2	357	2	KRTAP11-1	21	32253706	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	544318	32253706	15876189	238	35735											
TIAM1	7074	broad.mit.edu	37	chr21	32554912	32554912	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcatagaagagttcagggCgtcagcagcacgattattga	13	8	13	7	2	2	3	2	1	0	2	2	5	2	3	0	1	3	4	0	1	3	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:32554912C>T	uc002yow.1	-	16	3185	c.2713G>A	c.(2713-2715)GCC>ACC	p.A905T	TIAM1_uc011adk.1_Missense_Mutation_p.A905T|TIAM1_uc011adl.1_Missense_Mutation_p.A845T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	905	PDZ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GAGTTCAGGGCGTCAGCAGCA	0.498													5	63					0	0	0	0	T	32554912	T	T	32554912	3	4	194	1	0	0	0	0	1	0	0	0	15956	768	27	1	2118	1	TIAM1	21	32554912	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	301206	32554912	15574983	239	35736											
HSF2BP	11077	broad.mit.edu	37	chr21	45076541	45076541	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attctgggtaagaagtcccgTatttgcatcacttcagttgt	9	15	9	8	1	3	1	2	0	1	1	4	1	4	1	1	1	1	4	1	1	3	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:45076541T>A	uc002zdi.2	-	3	446	c.114A>T	c.(112-114)ATA>ATT	p.I38I	RRP1B_uc002zdk.2_5'Flank|HSF2BP_uc011aey.1_Intron	NM_007031	NP_008962	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding	38					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.18)		AGAAGTCCCGTATTTGCATCA	0.393													39	51					0	0	0	0	A	45076541	A	A	45076541	2	1	194	1	0	0	0	0	0	0	0	1	7436	1628	57	5		5	HSF2BP	21	45076541	Silent	SNP	T	TCGA-CV-6935-01A-11D-1912-08	12521629	45076541	3053354	240	35737											
COL6A2	1292	broad.mit.edu	37	chr21	47552400	47552400	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccgcgccgccgtgttccaCgagaaggactatgacagcct	9	6	12	14	5	0	2	0	1	0	1	1	5	1	3	5	1	1	1	5	1	2	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:47552400C>A	uc002zia.1	+	28	3076	c.2994C>A	c.(2992-2994)CAC>CAA	p.H998Q	COL6A2_uc002zib.1_Missense_Mutation_p.H404Q|COL6A2_uc002zic.1_Missense_Mutation_p.T73K|COL6A2_uc010gqe.1_RNA	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	998	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCGTGTTCCACGAGAAGGACT	0.572													7	18					8.12818e-05	9.97805e-05	1	0	A	47552400	A	A	47552400	3	1	194	1	0	0	0	0	1	0	0	0	3715	535	19	3	3430	3	COL6A2	21	47552400	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	2475859	47552400	577495	241	35738											
MYO18B	84700	broad.mit.edu	37	chr22	26242186	26242187	+	Missense_Mutation	DNP	CC	AA	AA																															gagccgcatggtgaggaggaCctttgccagcagccttgccg																										TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr22:26242186_26242187CC>AA	uc003abz.1	+	19	3738_3739	c.3488_3489CC>AA	c.(3487-3489)ACC>AAA	p.T1163K	MYO18B_uc003aca.1_Missense_Mutation_p.T1044K|MYO18B_uc010guy.1_Missense_Mutation_p.T1045K|MYO18B_uc010guz.1_Missense_Mutation_p.T1044K|MYO18B_uc011aka.1_Missense_Mutation_p.T317K|MYO18B_uc011akb.1_Missense_Mutation_p.T676K	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1163	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GTGAGGAGGACCTTTGCCAGCA	0.668													27	36					0	0	0	0	AA	26242187	AA	AA	26242186	3	1	194	1	0	0	0	0	1	0	0	0	10119	507	18	4	3558	4	MYO18B	22	26242186	Missense_Mutation	DNP	CC	TCGA-CV-6935-01A-11D-1912-08		26242186	25062380	242	35739											
HDHD1A	8226	broad.mit.edu	37	chrX	7023726	7023726	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctttcttccaccagctccTctttggacatcgggagctgc	5	12	10	14	1	2	0	0	0	2	0	5	2	4	2	3	3	3	3	3	3	0	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:7023726T>C	uc004crv.2	-	2	292	c.215A>G	c.(214-216)GAG>GGG	p.E72G	HDHD1A_uc011mhm.1_Missense_Mutation_p.E95G|HDHD1A_uc011mhn.1_Intron|HDHD1A_uc010ndl.2_Missense_Mutation_p.E72G|HDHD1A_uc011mho.1_Missense_Mutation_p.E72G	NM_012080	NP_036212	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain	72					nucleotide metabolic process		metal ion binding|phosphatase activity				0		Colorectal(8;0.0114)|Medulloblastoma(8;0.184)				CACCAGCTCCTCTTTGGACAT	0.502													16	0					0	0	0	0	C	7023726	C	C	7023726	3	2	194	1	0	0	0	0	1	0	0	0	7061	1551	54	5	604	5	HDHD1A	23	7023726	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08		7023726	148246834	243	35740											
CNKSR2	22866	broad.mit.edu	37	chrX	21627262	21627262	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagacttctcagtctcagtCttctcatgaggagtttcgcc	7	13	10	11	1	4	2	3	1	4	1	8	4	4	3	1	2	0	1	1	2	0	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:21627262C>G	uc004czx.1	+	20	2255	c.2219C>G	c.(2218-2220)TCT>TGT	p.S740C	CNKSR2_uc004czw.2_Missense_Mutation_p.S740C|CNKSR2_uc011mjn.1_Missense_Mutation_p.S691C|CNKSR2_uc011mjo.1_Missense_Mutation_p.S710C|CNKSR2_uc004czy.2_Missense_Mutation_p.S332C	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	740					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						CAGTCTCAGTCTTCTCATGAG	0.517													34	10					0	0	0	0	G	21627262	G	G	21627262	3	3	194	1	0	0	0	0	1	0	0	0	3622	913	32	2	2297	2	CNKSR2	23	21627262	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	14603536	21627262	133643298	244	35741											
YY2	404281	broad.mit.edu	37	chrX	21869684	21869684	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttcttcacggcagttctcAttagtggtgttgtacatgaa	9	16	9	7	1	3	1	2	1	2	0	4	1	3	1	0	2	1	4	0	2	3	6			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:21869684A>T	uc010nfq.2	+	4	693	c.496A>T	c.(496-498)ATT>TTT	p.I166F	MBTPS2_uc004dae.2_Missense_Mutation_p.I166F|MBTPS2_uc010nfr.2_5'Flank|MBTPS2_uc004dab.2_Missense_Mutation_p.I166F	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	Error:Variant_position_missing_in_O15391_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GGCAGTTCTCATTAGTGGTGT	0.373													5	78					0	0	0	0	T	21869684	T	T	21869684	3	4	194	1	0	0	0	0	1	0	0	0	17577	217	8	5		5	YY2	23	21869684	Missense_Mutation	SNP	A	TCGA-CV-6935-01A-11D-1912-08	242422	21869684	133400876	245	35742											
DMD	1756	broad.mit.edu	37	chrX	32328320	32328320	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagtgatttcagtcaaataaGtagaaggcacataagaaatt	18	10	9	4	0	2	3	2	1	0	2	2	4	2	3	0	1	0	2	0	1	6	5			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:32328320G>A	uc004dda.1	-	42	6240	c.5996C>T	c.(5995-5997)ACT>ATT	p.T1999I	DMD_uc004dcw.2_Missense_Mutation_p.T655I|DMD_uc004dcx.2_Missense_Mutation_p.T658I|DMD_uc004dcz.2_Missense_Mutation_p.T1876I|DMD_uc004dcy.1_Missense_Mutation_p.T1995I|DMD_uc004ddb.1_Missense_Mutation_p.T1991I|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1999					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGTCAAATAAGTAGAAGGCAC	0.393													21	7					0	0	0	0	A	32328320	A	A	32328320	3	1	194	1	0	0	0	0	1	0	0	0	4602	1029	36	4	5361	4	DMD	23	32328320	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	10458636	32328320	122942240	246	35743											
DMD	1756	broad.mit.edu	37	chrX	32404497	32404497	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagttctttgggattttccGtctgctttttctgtacaatc	6	19	7	9	1	3	0	0	0	3	0	5	1	4	1	1	1	2	3	1	1	3	7			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:32404497G>T	uc004dda.1	-	33	4848	c.4604C>A	c.(4603-4605)ACG>AAG	p.T1535K	DMD_uc004dcw.2_Missense_Mutation_p.T191K|DMD_uc004dcx.2_Missense_Mutation_p.T194K|DMD_uc004dcz.2_Missense_Mutation_p.T1412K|DMD_uc004dcy.1_Missense_Mutation_p.T1531K|DMD_uc004ddb.1_Missense_Mutation_p.T1527K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1535	Spectrin 10.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGGATTTTCCGTCTGCTTTTT	0.383													49	13					2.43139e-17	3.56204e-17	1	0	T	32404497	T	T	32404497	3	4	194	1	0	0	0	0	1	0	0	0	4602	1145	40	3	6789	3	DMD	23	32404497	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	76177	32404497	122866063	247	35744											
KDM6A	7403	broad.mit.edu	37	chrX	44938390	44938390	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacatttatgtattcatgaaGacctgggacttttctctact	10	17	6	8	0	2	2	1	1	1	1	3	3	2	3	1	1	2	1	1	1	5	8			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:44938390G>C	uc004dge.3	+	20	3314	c.2939_splice	c.e20-1	p.D980_splice	KDM6A_uc010nhk.2_Splice_Site_p.D946_splice|KDM6A_uc011mkz.1_Splice_Site_p.D1032_splice|KDM6A_uc011mla.1_Splice_Site_p.D935_splice|KDM6A_uc011mlb.1_Splice_Site_p.D987_splice|KDM6A_uc011mlc.1_Splice_Site_p.D684_splice|KDM6A_uc011mld.1_Splice_Site_p.D619_splice	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TATTCATGAAGACCTGGGACT	0.328			D|N|F|S		renal|oesophageal SCC|MM								11	1					0	0	0	0	C	44938390	C	C	44938390	5	2	194	1	0	0	0	0	0	0	1	0	8176	956	33	2	3016	2	KDM6A	23	44938390	Splice_Site	SNP	G	TCGA-CV-6935-01A-11D-1912-08	12533893	44938390	110332170	248	35745											
DRP2	1821	broad.mit.edu	37	chrX	100494001	100494001	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agaagtcaagtctcggggccCctacatctattctgtgctgg	8	11	11	11	1	4	1	1	0	3	1	5	1	4	1	2	3	2	1	2	3	4	3			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:100494001C>T	uc004egz.2	+	6	839	c.470C>T	c.(469-471)CCC>CTC	p.P157L	DRP2_uc011mrh.1_Missense_Mutation_p.P79L	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	157	Spectrin 1.				central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						TCTCGGGGCCCCTACATCTAT	0.463													58	16					0	0	0	0	T	100494001	T	T	100494001	3	4	194	1	0	0	0	0	1	0	0	0	4786	623	22	4	484	4	DRP2	23	100494001	Missense_Mutation	SNP	C	TCGA-CV-6935-01A-11D-1912-08	55555611	100494001	54776559	249	35746											
CAPN6	827	broad.mit.edu	37	chrX	110491846	110491846	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcaggagaaactcgctggTgcgaccatgctggaacatgg	10	8	13	10	2	1	1	1	0	1	1	3	4	1	2	1	4	4	2	1	4	2	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:110491846T>G	uc004epc.1	-	10	1603	c.1435A>C	c.(1435-1437)ACC>CCC	p.T479P	CAPN6_uc011msu.1_Missense_Mutation_p.T224P	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	479	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						AACTCGCTGGTGCGACCATGC	0.502													15	4					0	0	0	0	G	110491846	G	G	110491846	3	3	194	1	0	0	0	0	1	0	0	0	2642	1696	59	5	506	5	CAPN6	23	110491846	Missense_Mutation	SNP	T	TCGA-CV-6935-01A-11D-1912-08	9997845	110491846	44778714	250	35747											
ALG13	79868	broad.mit.edu	37	chrX	110924494	110924494	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaccagctttgacgacctCattgcgtgtgtgtcggcgcc	6	10	11	14	4	1	1	1	1	0	0	2	2	1	1	4	1	2	1	4	1	0	2			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:110924494C>T	uc011msy.1	+	1	82	c.48C>T	c.(46-48)CTC>CTT	p.L16L	ALG13_uc004epi.1_Silent_p.L16L|ALG13_uc011msw.1_5'UTR|ALG13_uc011msx.1_5'UTR|ALG13_uc011msz.1_5'UTR|ALG13_uc011mta.1_5'UTR|ALG13_uc011mtb.1_5'UTR			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	16					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						TTGACGACCTCATTGCGTGTG	0.632													123	30					0	0	0	0	T	110924494	T	T	110924494	2	4	194	1	0	0	0	0	0	0	0	1	515	813	29	2		2	ALG13	23	110924494	Silent	SNP	C	TCGA-CV-6935-01A-11D-1912-08	432648	110924494	44346066	251	35748											
SPANXN2	494119	broad.mit.edu	37	chrX	142795413	142795413	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatccttcagctgagtctaGgccttcgtcctcctcctctt	5	14	7	15	1	3	2	1	1	2	1	8	2	7	2	5	1	1	1	5	1	1	4			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:142795413G>T	uc004fbz.2	-	2	1019	c.265C>A	c.(265-267)CTA>ATA	p.L89I		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	89										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GCTGAGTCTAGGCCTTCGTCC	0.488													252	73					9.62967e-114	1.64816e-113	1	0	T	142795413	T	T	142795413	3	4	194	1	0	0	0	0	1	0	0	0	15057	991	35	4	281	4	SPANXN2	23	142795413	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	31870919	142795413	12475147	252	35749											
AFF2	2334	broad.mit.edu	37	chrX	148072769	148072769	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgatctggacacgctgatGgggcctctgacccagcacag	8	7	14	12	1	2	3	0	3	2	0	2	4	2	4	2	4	1	2	2	4	0	0			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:148072769G>T	uc004fcp.2	+	21	4322	c.3843G>T	c.(3841-3843)ATG>ATT	p.M1281I	AFF2_uc004fcq.2_Missense_Mutation_p.M1271I|AFF2_uc004fcr.2_Missense_Mutation_p.M1242I|AFF2_uc011mxb.1_Missense_Mutation_p.M1246I|AFF2_uc004fcs.2_Missense_Mutation_p.M1246I|AFF2_uc011mxc.1_Missense_Mutation_p.M922I	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1281					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ACACGCTGATGGGGCCTCTGA	0.493													62	18					2.02796e-37	3.38945e-37	1	0	T	148072769	T	T	148072769	3	4	194	1	0	0	0	0	1	0	0	0	357	1348	47	4	3980	4	AFF2	23	148072769	Missense_Mutation	SNP	G	TCGA-CV-6935-01A-11D-1912-08	5277356	148072769	7197791	253	35750											
AGRN	375790	broad.mit.edu	37	chr1	978800	978800	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggccacggcctgtaccctCgggcgggagatccaggtggc	6	5	17	13	3	0	1	0	0	0	1	2	3	1	1	4	6	1	1	4	6	1	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:978800C>T	uc001ack.1	+	8	1616	c.1566C>T	c.(1564-1566)CTC>CTT	p.L522L		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	522	Kazal-like 5.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CCTGTACCCTCGGGCGGGAGA	0.682													5	16					0	0	0	0	T	978800	T	T	978800	2	4	195	1	0	0	0	0	0	0	0	1	397	871	31	1		1	AGRN	1	978800	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08		978800	248271821	1	35751											
PER3	8863	broad.mit.edu	37	chr1	7896001	7896001	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatgacataccaggtacctGagaggtaagaaagcacttta	15	9	9	8	0	1	3	1	2	0	2	1	4	1	3	2	2	3	3	2	2	5	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:7896001G>C	uc001aoo.2	+	19	3542	c.3367G>C	c.(3367-3369)GAG>CAG	p.E1123Q	PER3_uc001aop.2_Missense_Mutation_p.E1132Q|PER3_uc010nzw.1_Missense_Mutation_p.E812Q	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	1123	CRY binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGTACCTGAGAGGTAAGA	0.313													4	39					0	0	0	0	C	7896001	C	C	7896001	3	2	195	1	0	0	0	0	1	0	0	0	11785	1291	45	2	3441	2	PER3	1	7896001	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	6917201	7896001	241354620	2	35752											
FBXO42	54455	broad.mit.edu	37	chr1	16641805	16641805	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atgtctagtctcctcagcctCcaatactgggtggggctcct	6	12	10	13	0	3	0	1	0	2	0	6	0	5	0	4	3	2	1	4	3	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:16641805C>G	uc001ayg.2	-	2	325	c.109G>C	c.(109-111)GAG>CAG	p.E37Q	FBXO42_uc001ayf.2_5'UTR|FBXO42_uc001ayh.2_Missense_Mutation_p.E37Q	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	37										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		TCCTCAGCCTCCAATACTGGG	0.498													5	52					0	0	0	0	G	16641805	G	G	16641805	3	3	195	1	0	0	0	0	1	0	0	0	5783	864	30	2	2080	2	FBXO42	1	16641805	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	8745804	16641805	232608816	3	35753											
PADI2	11240	broad.mit.edu	37	chr1	17397918	17397918	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacctggaagtacaggttctCctgcacaaggctctcgttgg	8	10	11	12	1	2	0	0	0	2	0	4	1	2	1	2	4	2	5	2	4	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:17397918C>T	uc001baf.2	-	14	1700	c.1618G>A	c.(1618-1620)GAG>AAG	p.E540K	PADI2_uc010ocm.1_Missense_Mutation_p.E424K	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	540					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TACAGGTTCTCCTGCACAAGG	0.597													15	39					0	0	0	0	T	17397918	T	T	17397918	3	4	195	1	0	0	0	0	1	0	0	0	11432	864	30	2	391	2	PADI2	1	17397918	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	756113	17397918	231852703	4	35754											
PADI4	23569	broad.mit.edu	37	chr1	17662722	17662722	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccagagctgtgaaagatcagGtaccactcacccaaacgctc	13	6	8	14	1	2	3	2	1	0	2	3	3	2	3	3	1	3	3	3	1	3	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:17662722G>A	uc001baj.2	+	4	436	c.408_splice	c.e4+1	p.Q136_splice	PADI4_uc009vpc.2_Splice_Site_p.Q136_splice	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV						chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GAAAGATCAGGTACCACTCAC	0.547											OREG0013149	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	26					0	0	0	0	A	17662722	A	A	17662722	5	1	195	1	0	0	0	0	0	0	1	0	11434	1275	44	4	423	4	PADI4	1	17662722	Splice_Site	SNP	G	TCGA-CV-6936-01A-11D-1912-08	264804	17662722	231587899	5	35755											
ALDH4A1	8659	broad.mit.edu	37	chr1	19204081	19204081	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgtcggccgagcggtgcacGaagtggaagttctttccgcc	7	8	14	12	6	1	0	0	0	1	0	3	3	2	1	3	3	2	2	3	3	2	2	rs150927009		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:19204081G>A	uc001bbb.2	-	10	1242	c.966C>T	c.(964-966)TTC>TTT	p.F322F	ALDH4A1_uc010ocu.1_Silent_p.F262F|ALDH4A1_uc001bbc.2_Silent_p.F322F	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	322					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	AGCGGTGCACGAAGTGGAAGT	0.657													7	17					0	0	0	0	A	19204081	A	A	19204081	2	1	195	1	0	0	0	0	0	0	0	1	501	1049	37	1		1	ALDH4A1	1	19204081	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1541359	19204081	230046540	6	35756											
TMCO4	255104	broad.mit.edu	37	chr1	20107215	20107215	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagctaccagaggctgctGaggcagcctctggcatggcc	7	7	13	14	0	2	2	1	1	1	1	2	2	2	2	3	4	4	5	3	4	1	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:20107215G>C	uc001bcn.2	-	4	279	c.37C>G	c.(37-39)CAG>GAG	p.Q13E	TMCO4_uc001bcm.2_Missense_Mutation_p.Q13E|TMCO4_uc001bco.1_Missense_Mutation_p.Q13E|TMCO4_uc001bcp.1_Missense_Mutation_p.Q13E|TMCO4_uc009vpn.1_Missense_Mutation_p.Q13E|TMCO4_uc001bcq.1_Missense_Mutation_p.Q13E	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	13						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		AGAGGCTGCTGAGGCAGCCTC	0.498													7	29					0	0	0	0	C	20107215	C	C	20107215	3	2	195	1	0	0	0	0	1	0	0	0	16064	1299	45	2	1919	2	TMCO4	1	20107215	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	903134	20107215	229143406	7	35757											
TMEM57	55219	broad.mit.edu	37	chr1	25810760	25810760	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggagaacgagctgctgcaGaacaagtacgtgcacctttc	12	7	11	11	2	0	2	0	0	0	2	1	4	0	2	1	1	7	5	1	1	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:25810760G>A	uc001bkk.2	+	7	1510	c.1308G>A	c.(1306-1308)CAG>CAA	p.Q436Q	TMEM57_uc009vru.2_Silent_p.Q209Q|TMEM57_uc009vrv.2_Silent_p.Q78Q	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	436						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		AGCTGCTGCAGAACAAGTACG	0.572													15	40					0	0	0	0	A	25810760	A	A	25810760	2	1	195	1	0	0	0	0	0	0	0	1	16250	933	33	2		2	TMEM57	1	25810760	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	5703545	25810760	223439861	8	35758											
AHDC1	27245	broad.mit.edu	37	chr1	27875878	27875878	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgggaaggtctggcgcgCggacaggacaggctgaaagg	9	5	20	7	3	1	1	0	1	1	0	1	4	1	4	0	8	0	1	0	8	2	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:27875878C>T	uc009vsy.2	-	6	3718	c.2749G>A	c.(2749-2751)GCG>ACG	p.A917T	AHDC1_uc009vsz.1_Missense_Mutation_p.A917T	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	917							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GTCTGGCGCGCGGACAGGACA	0.697													16	43					0	0	0	0	T	27875878	T	T	27875878	3	4	195	1	0	0	0	0	1	0	0	0	412	768	27	1	2066	1	AHDC1	1	27875878	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	2065118	27875878	221374743	9	35759											
MACF1	23499	broad.mit.edu	37	chr1	39749116	39749116	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctccagatgaaaagtctgtaAtcacttatgtgtcttcgatt	11	15	7	8	1	3	2	1	1	2	1	5	3	4	2	1	0	0	1	1	0	4	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:39749116A>G	uc010ois.1	+	10	1064	c.859A>G	c.(859-861)ATC>GTC	p.I287V	MACF1_uc001cda.1_Missense_Mutation_p.I195V	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	287	Actin-binding.|CH 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAAGTCTGTAATCACTTATGT	0.418													13	37					0	0	0	0	G	39749116	G	G	39749116	3	3	195	1	0	0	0	0	1	0	0	0	9195	101	4	5	889	5	MACF1	1	39749116	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	11873238	39749116	209501505	10	35760											
PABPC4	8761	broad.mit.edu	37	chr1	40027815	40027815	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtctatctccagcagcattCccgtgatcttcccagccaga	8	11	7	15	1	3	2	0	1	3	1	6	2	5	2	4	0	3	2	4	0	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:40027815C>T	uc010oiv.1	-	14	2673	c.1775G>A	c.(1774-1776)GGA>GAA	p.G592E	PPIEL_uc001cdk.2_5'Flank|PABPC4_uc001cdl.2_Missense_Mutation_p.G608E|PABPC4_uc001cdm.2_Missense_Mutation_p.G579E	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	592	PABC.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CAGCAGCATTCCCGTGATCTT	0.498													7	28					0	0	0	0	T	40027815	T	T	40027815	3	4	195	1	0	0	0	0	1	0	0	0	11420	855	30	2	167	2	PABPC4	1	40027815	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	278699	40027815	209222806	11	35761											
NSUN4	387338	broad.mit.edu	37	chr1	46826430	46826430	+	Frame_Shift_Del	DEL	A	-	-																															actcccttcatgaggaggagAacaacatctttaagcggtca																										TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:46826430delA	uc001cpr.1	+	5	917	c.808delA	c.(808-810)AACfs	p.N270fs	NSUN4_uc010omc.1_Frame_Shift_Del_p.N221fs|NSUN4_uc009vyf.1_Frame_Shift_Del_p.N119fs|NSUN4_uc009vyg.1_Frame_Shift_Del_p.N221fs|NSUN4_uc001cpt.1_RNA|NSUN4_uc001cps.1_RNA	NM_199044	NP_950245	Q96CB9	NSUN4_HUMAN	NOL1/NOP2/Sun domain family 4 protein	270							methyltransferase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGAGGAGGAGAACAACATCTT	0.473													---	---	---								-	46826430	-	-	46826430	7	5	195	1	0	1	0	1	0	0	0	0	10734	246	9	0	826	0	NSUN4	1	46826430	Frame_Shift_Del	DEL	A	TCGA-CV-6936-01A-11D-1912-08	6798615	46826430	202424191	12	35762											
LEPR	3953	broad.mit.edu	37	chr1	66101929	66101929	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatcagtgacatgtggtcCtcttcttttggagcctgaaa	9	13	10	9	0	3	2	1	2	2	0	4	3	4	3	2	2	2	1	2	2	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:66101929C>A	uc001dci.2	+	20	2931	c.2729C>A	c.(2728-2730)CCT>CAT	p.P910H	LEPR_uc009waq.2_3'UTR	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	910	Cytoplasmic (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ACATGTGGTCCTCTTCTTTTG	0.348													39	96					7.63091e-17	1.47118e-16	1	0	A	66101929	A	A	66101929	3	1	195	1	0	0	0	0	1	0	0	0	8768	681	24	4	3029	4	LEPR	1	66101929	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	19275499	66101929	183148692	13	35763											
ZNF326	284695	broad.mit.edu	37	chr1	90459386	90459386	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtagctgttcaggcgctcCgcatccagctgttgccgccg	5	9	12	15	5	1	0	1	0	0	0	3	0	3	0	4	1	3	7	4	1	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:90459386C>T	uc001dnq.2	+						GEMIN8P4_uc001dno.2_RNA|ZNF326_uc001dnp.3_5'Flank|ZNF326_uc009wda.1_5'Flank|ZNF326_uc001dnr.2_5'Flank	NM_182976	NP_892021	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			ovary(1)	1		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		TCAGGCGCTCCGCATCCAGCT	0.602													22	38					0	0	0	0	T	90459386	T	T	90459386	1	4	195	0	1	0	0	0	0	0	0	0	17913	667	23	1		1	ZNF326	1	90459386	5'Flank	SNP	C	TCGA-CV-6936-01A-11D-1912-08	24357457	90459386	158791235	14	35764											
CHI3L2	1117	broad.mit.edu	37	chr1	111777615	111777615	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaggaaccataactttgatgGactggatgtaagctggatct	12	11	12	6	0	1	1	0	1	1	0	1	6	1	5	1	4	3	2	1	4	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:111777615G>C	uc001eam.2	+	5	487	c.416G>C	c.(415-417)GGA>GCA	p.G139A	CHI3L2_uc001ean.2_Missense_Mutation_p.G129A|CHI3L2_uc001eao.2_Missense_Mutation_p.G60A|CHI3L2_uc009wga.2_Missense_Mutation_p.G60A	NM_004000	NP_003991	Q15782	CH3L2_HUMAN	chitinase 3-like 2 isoform a	139					chitin catabolic process	extracellular space	cation binding|chitinase activity			central_nervous_system(1)	1		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		AACTTTGATGGACTGGATGTA	0.398													4	43					0	0	0	0	C	111777615	C	C	111777615	3	2	195	1	0	0	0	0	1	0	0	0	3356	1174	41	2	434	2	CHI3L2	1	111777615	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	21318229	111777615	137473006	15	35765											
PSMD4	5710	broad.mit.edu	37	chr1	151237665	151237665	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaaactggctaaacgcctCaagaaggagaaagtaaatgt	17	7	11	6	1	1	3	1	1	0	2	1	4	1	3	1	2	2	2	1	2	8	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:151237665C>G	uc001exl.2	+	5	455	c.393C>G	c.(391-393)CTC>CTG	p.L131L	PSMD4_uc001exn.2_Silent_p.L131L	NM_002810	NP_002801	P55036	PSMD4_HUMAN	proteasome 26S non-ATPase subunit 4	131	VWFA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTAAACGCCTCAAGAAGGAGA	0.443													3	47					0	0	0	0	G	151237665	G	G	151237665	2	3	195	1	0	0	0	0	0	0	0	1	12762	813	29	2		2	PSMD4	1	151237665	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	39460050	151237665	98012956	16	35766											
FLG2	388698	broad.mit.edu	37	chr1	152327481	152327481	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagatgactgacttgagccAgaaccatgttggccatagct	11	9	10	11	0	0	5	0	3	0	2	0	5	0	5	4	1	3	2	4	1	2	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:152327481A>G	uc001ezw.3	-	3	2854	c.2781T>C	c.(2779-2781)TCT>TCC	p.S927S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	927	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTTGAGCCAGAACCATGTT	0.488													498	306					0	0	0	0	G	152327481	G	G	152327481	2	3	195	1	0	0	0	0	0	0	0	1	5955	175	7	5		5	FLG2	1	152327481	Silent	SNP	A	TCGA-CV-6936-01A-11D-1912-08	1089816	152327481	96923140	17	35767											
ILF2	3608	broad.mit.edu	37	chr1	153636573	153636573	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagccaggaaaacgaatcctCaagtccttcagtagtctgat	14	9	8	10	1	3	1	2	1	1	0	5	3	5	2	3	1	2	1	3	1	6	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:153636573C>G	uc001fcr.2	-	10	771	c.690G>C	c.(688-690)TTG>TTC	p.L230F	ILF2_uc010pdy.1_Missense_Mutation_p.L192F|ILF2_uc009wok.2_Missense_Mutation_p.L208F	NM_004515	NP_004506	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	230	DZF.				immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AACGAATCCTCAAGTCCTTCA	0.398													6	33					0	0	0	0	G	153636573	G	G	153636573	3	3	195	1	0	0	0	0	1	0	0	0	7750	825	29	2	502	2	ILF2	1	153636573	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	1309092	153636573	95614048	18	35768											
IL6R	3570	broad.mit.edu	37	chr1	154437818	154437818	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccagggacccacggagccctTatgacatcagcaatacagac	13	5	9	14	1	1	2	1	1	0	1	1	4	1	4	3	2	3	1	3	2	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:154437818T>G	uc001fez.1	+	10	1806	c.1369T>G	c.(1369-1371)TAT>GAT	p.Y457D	IL6R_uc001ffa.1_3'UTR	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	457	Cytoplasmic (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACGGAGCCCTTATGACATCAG	0.577													7	128					0	0	0	0	G	154437818	G	G	154437818	3	3	195	1	0	0	0	0	1	0	0	0	7741	1754	61	5	1407	5	IL6R	1	154437818	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	801245	154437818	94812803	19	35769											
PMVK	10654	broad.mit.edu	37	chr1	154898882	154898882	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgctccaacgctacaacGcggaccgtctgcgtcacggc	7	7	10	17	6	3	0	1	0	2	0	4	1	4	1	2	2	5	2	2	2	3	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:154898882G>A	uc001ffq.2	-	4	713	c.390C>T	c.(388-390)CGC>CGT	p.R130R		NM_006556	NP_006547	Q15126	PMVK_HUMAN	phosphomevalonate kinase	130				R->M: Approximately 4-fold decrease in Vmax for MgATP and R-MVP. Approximately 3-fold increase in Km for MgATP and R- MVP.	cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding				0	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ACGCTACAACGCGGACCGTCT	0.627													7	73					0	0	0	0	A	154898882	A	A	154898882	2	1	195	1	0	0	0	0	0	0	0	1	12199	1074	38	1		1	PMVK	1	154898882	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	461064	154898882	94351739	20	35770											
CCT3	7203	broad.mit.edu	37	chr1	156290786	156290786	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgttgatgatgttcagcatCatatcactgtcactgatgtc	9	15	8	9	0	4	3	4	3	0	0	5	3	4	3	0	0	1	3	0	0	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:156290786C>G	uc001fol.1	-	7	673	c.453G>C	c.(451-453)ATG>ATC	p.M151I	CCT3_uc001fom.1_Missense_Mutation_p.M150I|CCT3_uc001fon.1_Missense_Mutation_p.M113I|CCT3_uc010phj.1_Missense_Mutation_p.M105I|CCT3_uc010phk.1_Missense_Mutation_p.M105I|CCT3_uc010phl.1_Missense_Mutation_p.M105I	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	151					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					TGTTCAGCATCATATCACTGT	0.423													8	109					0	0	0	0	G	156290786	G	G	156290786	3	3	195	1	0	0	0	0	1	0	0	0	2969	826	29	2	1216	2	CCT3	1	156290786	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	1391904	156290786	92959835	21	35771											
SPTA1	6708	broad.mit.edu	37	chr1	158641861	158641861	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgttacctcttgtctactCatccaactgtccacttgctc	6	14	4	17	1	3	0	1	0	2	0	6	0	5	0	4	0	4	2	4	0	3	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:158641861C>G	uc001fst.1	-	11	1675	c.1476G>C	c.(1474-1476)ATG>ATC	p.M492I		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	492	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTTGTCTACTCATCCAACTGT	0.498													27	116					0	0	0	0	G	158641861	G	G	158641861	3	3	195	1	0	0	0	0	1	0	0	0	15182	826	29	2	5951	2	SPTA1	1	158641861	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	2351075	158641861	90608760	22	35772											
FCRLA	84824	broad.mit.edu	37	chr1	161681748	161681748	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttccagcgccaattctcaGagctgtaccctcagctgaac	9	10	8	14	1	2	2	2	1	1	1	4	2	3	2	3	0	5	4	3	0	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:161681748G>C	uc001gbe.2	+	5	835	c.593G>C	c.(592-594)AGA>ACA	p.R198T	FCRLA_uc001gbd.2_Missense_Mutation_p.R192T|FCRLA_uc001gbf.2_Missense_Mutation_p.R103T|FCRLA_uc001gbg.2_Missense_Mutation_p.R52T|FCRLA_uc009wuo.2_Missense_Mutation_p.R58T|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	175	Ig-like C2-type 2.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			CCAATTCTCAGAGCTGTACCC	0.527													5	443					0	0	0	0	C	161681748	C	C	161681748	3	2	195	1	0	0	0	0	1	0	0	0	5832	942	33	2	611	2	FCRLA	1	161681748	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	3039887	161681748	87568873	23	35773											
C1orf114	57821	broad.mit.edu	37	chr1	169391472	169391472	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaaagatttgtcaggatcaGaatgccgtttggtgtgctcc	9	12	12	8	1	2	2	2	0	0	2	3	3	3	3	2	2	2	3	2	2	2	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:169391472G>C	uc001gga.1	-	3	365	c.197C>G	c.(196-198)TCT>TGT	p.S66C	C1orf114_uc001gfz.1_Missense_Mutation_p.S66C|C1orf114_uc009wvq.1_Missense_Mutation_p.S66C|C1orf114_uc001ggb.2_Missense_Mutation_p.S66C|C1orf114_uc001ggc.1_Missense_Mutation_p.S66C	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	66											0	all_hematologic(923;0.208)					GTCAGGATCAGAATGCCGTTT	0.378													8	84					0	0	0	0	C	169391472	C	C	169391472	3	2	195	1	0	0	0	0	1	0	0	0	1996	942	33	2	1345	2	C1orf114	1	169391472	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	7709724	169391472	79859149	24	35774											
TDRD5	163589	broad.mit.edu	37	chr1	179562647	179562647	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcttagttgcaaaacagagGagcagccataagcttcgaaa	16	7	10	8	1	0	1	0	0	0	1	1	3	0	2	1	1	6	5	1	1	5	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:179562647G>A	uc001gnf.1	+	3	535	c.285G>A	c.(283-285)AGG>AGA	p.R95R	TDRD5_uc010pnp.1_Silent_p.R95R	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	95	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CAAAACAGAGGAGCAGCCATA	0.438													15	43					0	0	0	0	A	179562647	A	A	179562647	2	1	195	1	0	0	0	0	0	0	0	1	15799	1165	41	2		2	TDRD5	1	179562647	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	10171175	179562647	69687974	25	35775											
TPR	7175	broad.mit.edu	37	chr1	186312565	186312565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actctcaacctgagccacctCaaacctagtttcagcaattt	12	11	4	14	0	3	1	3	1	1	0	4	1	3	1	4	0	4	2	4	0	4	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:186312565C>T	uc001grv.2	-	27	3940	c.3643G>A	c.(3643-3645)GAG>AAG	p.E1215K		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1215	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TGAGCCACCTCAAACCTAGTT	0.353			T	NTRK1	papillary thyroid								20	99					0	0	0	0	T	186312565	T	T	186312565	3	4	195	1	0	0	0	0	1	0	0	0	16483	835	29	2	3548	2	TPR	1	186312565	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	6749918	186312565	62938056	26	35776											
CFH	3075	broad.mit.edu	37	chr1	196709904	196709904	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttaggagaaaaatggtctCaccctccatcatgcataagt	13	10	8	10	0	2	1	2	0	1	1	4	2	3	1	2	2	1	2	2	2	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:196709904C>T	uc001gtj.3	+	18	3178	c.2938C>T	c.(2938-2940)CAC>TAC	p.H980Y		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	980	Sushi 16.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						AAAATGGTCTCACCCTCCATC	0.338													8	113					0	0	0	0	T	196709904	T	T	196709904	3	4	195	1	0	0	0	0	1	0	0	0	3298	826	29	2	3026	2	CFH	1	196709904	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	10397339	196709904	52540717	27	35777											
CFHR2	3080	broad.mit.edu	37	chr1	196920100	196920100	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacagacttcaaaacaatgaGaacaacatttcatgtgtaga	18	10	6	7	0	2	3	2	1	0	3	2	4	2	3	0	0	4	1	0	0	7	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:196920100G>A	uc001gtq.1	+	3	449	c.372G>A	c.(370-372)GAG>GAA	p.E124E	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	124	Sushi 2.					extracellular region				skin(2)|ovary(1)	3						AAAACAATGAGAACAACATTT	0.393													13	120					0	0	0	0	A	196920100	A	A	196920100	2	1	195	1	0	0	0	0	0	0	0	1	3300	933	33	2		2	CFHR2	1	196920100	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	210196	196920100	52330521	28	35778											
CRB1	23418	broad.mit.edu	37	chr1	197298069	197298069	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgcttcagatccctgcaaGaacgaggctacatgcctcaa	11	9	9	12	1	2	2	2	0	0	2	3	3	3	2	2	1	5	3	2	1	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:197298069G>A	uc001gtz.2	+	2	723	c.588G>A	c.(586-588)AAG>AAA	p.K196K	CRB1_uc010poz.1_Silent_p.K127K|CRB1_uc001gty.1_Silent_p.K196K|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.K196K|CRB1_uc010ppb.1_Silent_p.K196K	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	196	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ATCCCTGCAAGAACGAGGCTA	0.448													4	68					0	0	0	0	A	197298069	A	A	197298069	2	1	195	1	0	0	0	0	0	0	0	1	3863	933	33	2		2	CRB1	1	197298069	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	377969	197298069	51952552	29	35779											
PPP1R12B	4660	broad.mit.edu	37	chr1	202457699	202457699	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgggatgaggaagcagagtCtttacggaaagcacgctcca	13	6	13	9	3	1	2	0	1	1	1	2	5	2	5	1	3	3	3	1	3	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:202457699C>G	uc001gya.1	+	14	2033	c.1889C>G	c.(1888-1890)TCT>TGT	p.S630C	PPP1R12B_uc001gxz.1_Missense_Mutation_p.S630C|PPP1R12B_uc001gyb.1_5'UTR|PPP1R12B_uc001gyc.1_5'UTR	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	630					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GAAGCAGAGTCTTTACGGAAA	0.433													41	24					0	0	0	0	G	202457699	G	G	202457699	3	3	195	1	0	0	0	0	1	0	0	0	12415	913	32	2	2033	2	PPP1R12B	1	202457699	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	5159630	202457699	46792922	30	35780											
KLHL12	59349	broad.mit.edu	37	chr1	202863774	202863774	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccggcaccttcccgggctgtCtgcatatctcccagcatgct	5	10	9	17	2	2	0	0	0	2	0	4	0	3	0	4	2	3	5	4	2	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:202863774C>G	uc001gyo.1	-	9	1439	c.1239G>C	c.(1237-1239)CAG>CAC	p.Q413H	KLHL12_uc001gym.1_Missense_Mutation_p.Q146H|KLHL12_uc001gyn.1_Missense_Mutation_p.Q263H|KLHL12_uc010pqc.1_Missense_Mutation_p.Q451H|KLHL12_uc009xah.1_Missense_Mutation_p.Q312H	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	413	Kelch 3.|Interaction with DVL3.				Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			CCCGGGCTGTCTGCATATCTC	0.527													28	262					0	0	0	0	G	202863774	G	G	202863774	3	3	195	1	0	0	0	0	1	0	0	0	8407	912	32	2	483	2	KLHL12	1	202863774	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	406075	202863774	46386847	31	35781											
CHIT1	1118	broad.mit.edu	37	chr1	203186208	203186208	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgctcaggttcagagggctGacctggttttggaacttcaa	9	12	12	8	0	3	2	3	1	0	1	3	3	3	3	1	4	2	4	1	4	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:203186208G>A	uc001gzn.2	-	11	1306	c.1210C>T	c.(1210-1212)CAG>TAG	p.Q404*	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_Intron|CHIT1_uc009xal.1_Nonsense_Mutation_p.Q166*|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Nonsense_Mutation_p.Q395*	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	404					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						TCAGAGGGCTGACCTGGTTTT	0.567											OREG0014113	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	122					0	0	0	0	A	203186208	A	A	203186208	4	1	195	1	0	0	0	0	0	1	0	0	3361	1299	45	2	194	2	CHIT1	1	203186208	Nonsense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	322434	203186208	46064413	32	35782											
FMOD	2331	broad.mit.edu	37	chr1	203316510	203316510	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgtaggagaggtctagctCaaggaggctgctggaattga	10	10	16	5	0	2	2	1	1	1	1	2	5	2	4	0	5	2	5	0	5	4	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:203316510C>T	uc001gzr.2	-	2	1025	c.889G>A	c.(889-891)GAG>AAG	p.E297K	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	297	LRR 9.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			AGGTCTAGCTCAAGGAGGCTG	0.557													114	105					0	0	0	0	T	203316510	T	T	203316510	3	4	195	1	0	0	0	0	1	0	0	0	5991	835	29	2	249	2	FMOD	1	203316510	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	130302	203316510	45934111	33	35783											
REN	5972	broad.mit.edu	37	chr1	204128555	204128555	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagaaagagaagacgtcctCttttagcaccccttgggaga	12	9	11	9	1	1	4	0	0	1	4	2	6	2	4	3	1	1	2	3	1	4	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:204128555C>G	uc001haq.2	-	5	705	c.661G>C	c.(661-663)GAG>CAG	p.E221Q		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	221					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AAGACGTCCTCTTTTAGCACC	0.562													18	104					0	0	0	0	G	204128555	G	G	204128555	3	3	195	1	0	0	0	0	1	0	0	0	13289	922	32	2	583	2	REN	1	204128555	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	812045	204128555	45122066	34	35784											
PIK3C2B	5287	broad.mit.edu	37	chr1	204400897	204400897	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtggcctcgtgagtgttctCtcgcatcacctttaccacat	6	13	9	13	2	2	1	1	1	1	0	5	1	2	1	3	2	1	2	3	2	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:204400897C>G	uc001haw.2	-	29	4659	c.4180G>C	c.(4180-4182)GAG>CAG	p.E1394Q	PIK3C2B_uc010pqv.1_Missense_Mutation_p.E1366Q	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1394	PX.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TGAGTGTTCTCTCGCATCACC	0.532											OREG0014134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	275					0	0	0	0	G	204400897	G	G	204400897	3	3	195	1	0	0	0	0	1	0	0	0	11965	922	32	2	748	2	PIK3C2B	1	204400897	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	272342	204400897	44849724	35	35785											
SLC41A1	254428	broad.mit.edu	37	chr1	205779410	205779410	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacccccttggcgttggcccGagactcaatcaccacctcta	9	8	7	17	2	3	1	2	0	1	1	3	2	3	1	5	2	1	1	5	2	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:205779410G>A	uc001hdh.1	-	2	1032	c.160C>T	c.(160-162)CGG>TGG	p.R54W		NM_173854	NP_776253	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 member 1	54						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			skin(2)	2	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GCGTTGGCCCGAGACTCAATC	0.652											OREG0014163	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	99					0	0	0	0	A	205779410	A	A	205779410	3	1	195	1	0	0	0	0	1	0	0	0	14693	1057	37	1	1421	1	SLC41A1	1	205779410	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1378513	205779410	43471211	36	35786											
CR1	1378	broad.mit.edu	37	chr1	207741206	207741206	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctccagttattcctaatggGagacacacaggaaaacctct	13	9	7	12	0	1	1	0	0	1	1	3	3	3	2	4	2	1	1	4	2	4	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:207741206G>A	uc001hfy.2	+	17	2780	c.2640G>A	c.(2638-2640)GGG>GGA	p.G880G	CR1_uc009xcl.1_Silent_p.G430G|CR1_uc001hfx.2_Silent_p.G1330G|CR1_uc009xck.1_Silent_p.G430G	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	880	Extracellular (Potential).|Sushi 14.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TTCCTAATGGGAGACACACAG	0.433													10	367					0	0	0	0	A	207741206	A	A	207741206	2	1	195	1	0	0	0	0	0	0	0	1	3855	1161	41	2		2	CR1	1	207741206	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1961796	207741206	41509415	37	35787											
LIN9	286826	broad.mit.edu	37	chr1	226474137	226474137	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttagacatacacagaagtCattatcaccttcaaaaagtg	16	11	5	9	0	3	2	3	0	0	2	3	2	3	2	1	0	1	0	1	0	6	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:226474137C>G	uc001hqa.2	-	6	779	c.469G>C	c.(469-471)GAC>CAC	p.D157H	LIN9_uc001hqb.2_Missense_Mutation_p.D122H|LIN9_uc001hqc.2_Missense_Mutation_p.D89H|LIN9_uc009xel.1_Missense_Mutation_p.D122H	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	141	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		ACACAGAAGTCATTATCACCT	0.318													24	63					0	0	0	0	G	226474137	G	G	226474137	3	3	195	1	0	0	0	0	1	0	0	0	8855	826	29	2	1247	2	LIN9	1	226474137	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	18732931	226474137	22776484	38	35788											
OBSCN	84033	broad.mit.edu	37	chr1	228432256	228432256	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggggccagagagtctccttCcacctgcacatcacaggtga	9	7	12	13	0	2	2	1	1	1	1	4	3	3	2	4	3	1	1	4	3	0	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:228432256C>T	uc009xez.1	+	11	3509	c.3465C>T	c.(3463-3465)TTC>TTT	p.F1155F	OBSCN_uc001hsn.2_Silent_p.F1155F	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1155	Ig-like 11.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GAGTCTCCTTCCACCTGCACA	0.542													11	196					0	0	0	0	T	228432256	T	T	228432256	2	4	195	1	0	0	0	0	0	0	0	1	10866	854	30	2		2	OBSCN	1	228432256	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	1958119	228432256	20818365	39	35789											
OBSCN	84033	broad.mit.edu	37	chr1	228521393	228521393	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaccctggagatcatctcCgtcacccgggaggactctgg	8	7	11	15	2	4	1	2	0	2	1	5	4	4	3	3	4	0	0	3	4	0	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr1:228521393C>T	uc009xez.1	+	59	16010	c.15966C>T	c.(15964-15966)TCC>TCT	p.S5322S	OBSCN_uc001hsn.2_Silent_p.S5322S|OBSCN_uc001hsr.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5322	Ig-like 50.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGATCATCTCCGTCACCCGGG	0.582													9	8					0	0	0	0	T	228521393	T	T	228521393	2	4	195	1	0	0	0	0	0	0	0	1	10866	639	23	1		1	OBSCN	1	228521393	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	89137	228521393	20729228	40	35790											
OBSCN	84033	broad.mit.edu	37	chr1	228556503	228556503	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgcccagaacatcaccccAgcagagctgcagttcagcca	11	7	8	15	0	2	2	2	0	0	2	2	2	2	2	4	0	6	4	4	0	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:228556503A>G	uc009xez.1	+	89	19892	c.19848A>G	c.(19846-19848)CCA>CCG	p.P6616P	OBSCN_uc001hsr.1_Silent_p.P1245P	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6616	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACATCACCCCAGCAGAGCTGC	0.567													158	98					0	0	0	0	G	228556503	G	G	228556503	2	3	195	1	0	0	0	0	0	0	0	1	10866	175	7	5		5	OBSCN	1	228556503	Silent	SNP	A	TCGA-CV-6936-01A-11D-1912-08	35110	228556503	20694118	41	35791											
TRIM67	440730	broad.mit.edu	37	chr1	231335933	231335933	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcactgcacattgaagctgCgtcagtccaccggactgatg	10	9	10	12	2	2	2	2	2	0	0	3	3	3	3	2	1	3	2	2	1	1	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:231335933C>T	uc009xfn.1	+	4	1345	c.1303C>T	c.(1303-1305)CGT>TGT	p.R435C		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	435						cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				ATTGAAGCTGCGTCAGTCCAC	0.532													14	219					0	0	0	0	T	231335933	T	T	231335933	3	4	195	1	0	0	0	0	1	0	0	0	16607	768	27	1	1317	1	TRIM67	1	231335933	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	2779430	231335933	17914688	42	35792											
FMN2	56776	broad.mit.edu	37	chr1	240371390	240371390	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccacctccccctctacccgGagcgggcataccccctccgc	5	5	7	24	3	1	0	0	0	1	0	3	1	3	1	8	2	3	1	8	2	2	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:240371390G>A	uc010pyd.1	+	5	3503	c.3278G>A	c.(3277-3279)GGA>GAA	p.G1093E	FMN2_uc010pye.1_Missense_Mutation_p.G1097E	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1093	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTCTACCCGGAGCGGGCATA	0.726													3	9					0	0	0	0	A	240371390	A	A	240371390	3	1	195	1	0	0	0	0	1	0	0	0	5982	1174	41	2	3296	2	FMN2	1	240371390	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	9035457	240371390	8879231	43	35793											
AHCTF1	25909	broad.mit.edu	37	chr1	247040301	247040301	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcttcaaggcaggcacataaTtggcacgctgcaaatggtgc	11	8	12	10	1	1	0	1	0	0	0	1	0	1	0	0	4	2	6	0	4	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:247040301T>C	uc001ibu.1	-	22	2895	c.2888A>G	c.(2887-2889)AAT>AGT	p.N963S	AHCTF1_uc001ibv.1_Missense_Mutation_p.N972S|AHCTF1_uc009xgs.1_5'UTR|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	963	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			AGGCACATAATTGGCACGCTG	0.378													12	79					0	0	0	0	C	247040301	C	C	247040301	3	2	195	1	0	0	0	0	1	0	0	0	408	1493	52	5	3968	5	AHCTF1	1	247040301	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	6668911	247040301	2210320	44	35794											
OR2L3	391192	broad.mit.edu	37	chr1	248224496	248224496	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	attccttattgccaatccagGgccatcaatcatttcttctg	9	15	5	12	0	4	0	2	0	2	0	6	0	6	0	4	1	1	0	4	1	3	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr1:248224496G>T	uc001idx.1	+	1	513	c.513G>T	c.(511-513)AGG>AGT	p.R171S	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GCCAATCCAGGGCCATCAATC	0.473													32	219					1.74807e-11	3.30077e-11	1	0	T	248224496	T	T	248224496	3	4	195	1	0	0	0	0	1	0	0	0	11062	1223	43	4	515	4	OR2L3	1	248224496	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1184195	248224496	1026125	45	35795											
APOB	338	broad.mit.edu	37	chr2	21224885	21224885	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttatttcctgagcagtggcaGaaagctctgcaatcttctct	9	14	8	10	0	3	2	0	1	3	1	5	2	4	2	1	1	3	4	1	1	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:21224885G>A	uc002red.2	-	29	13537	c.13409C>T	c.(13408-13410)TCT>TTT	p.S4470F		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4470					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGCAGTGGCAGAAAGCTCTGC	0.383													12	71					0	0	0	0	A	21224885	A	A	21224885	3	1	195	1	0	0	0	0	1	0	0	0	785	942	33	2	286	2	APOB	2	21224885	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08		21224885	221974488	46	35796											
PFN4	375189	broad.mit.edu	37	chr2	24345335	24345335	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctccgctcctggattttgAtgagggctgcactgtccaca	7	11	11	12	1	0	2	0	2	0	0	3	3	3	3	3	2	2	4	3	2	0	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:24345335A>T	uc002rfa.1	-	2	247	c.71T>A	c.(70-72)ATC>AAC	p.I24N	LOC375190_uc002rew.2_Intron|LOC375190_uc010ykl.1_5'Flank|LOC375190_uc002rfb.2_5'Flank	NM_199346	NP_955378	Q8NHR9	PROF4_HUMAN	profilin family, member 4	24					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGATTTTGATGAGGGCTGC	0.428													65	49					0	0	0	0	T	24345335	T	T	24345335	3	4	195	1	0	0	0	0	1	0	0	0	11825	333	12	5	334	5	PFN4	2	24345335	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	3120450	24345335	218854038	47	35797											
DNMT3A	1788	broad.mit.edu	37	chr2	25463307	25463307	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtagaactcaaagaagagcCggccagtgccctctgagagg	12	5	14	10	1	2	4	1	1	1	4	2	5	2	4	3	3	3	1	3	3	4	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:25463307C>T	uc002rgc.2	-	19	2443	c.2186G>A	c.(2185-2187)CGG>CAG	p.R729Q	DNMT3A_uc002rgd.2_Missense_Mutation_p.R729Q|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.R540Q	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	729					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding	p.R729Q(1)|p.R729W(1)		haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAAGAAGAGCCGGCCAGTGCC	0.612			Mis|F|N|S		AML								30	28					0	0	0	0	T	25463307	T	T	25463307	3	4	195	1	0	0	0	0	1	0	0	0	4698	652	23	1	572	1	DNMT3A	2	25463307	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	1117972	25463307	217736066	48	35798											
EHBP1	23301	broad.mit.edu	37	chr2	63217961	63217961	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagctgtaactgagagctcaGagcaggacatgaaagtaagt	16	7	12	6	0	1	3	1	2	0	2	1	5	1	4	0	1	4	5	0	1	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:63217961G>A	uc002sby.2	+	18	3414	c.2932G>A	c.(2932-2934)GAG>AAG	p.E978K	EHBP1_uc010fcp.2_Missense_Mutation_p.E907K|EHBP1_uc002sbz.2_Missense_Mutation_p.E907K|EHBP1_uc002scb.2_Missense_Mutation_p.E943K	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	978						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TGAGAGCTCAGAGCAGGACAT	0.418									Hereditary_Prostate_Cancer				6	38					0	0	0	0	A	63217961	A	A	63217961	3	1	195	1	0	0	0	0	1	0	0	0	4997	943	33	2	2998	2	EHBP1	2	63217961	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	37754654	63217961	179981412	49	35799											
MEIS1	4211	broad.mit.edu	37	chr2	66775128	66775128	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggcacaagacacgggactCaccatccttcaagtgaacaa	14	7	8	12	1	2	2	2	1	0	1	3	3	3	3	2	2	1	1	2	2	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:66775128C>T	uc002sdu.2	+	9	1399	c.942C>T	c.(940-942)CTC>CTT	p.L314L	MEIS1_uc002sdt.2_Silent_p.L314L|MEIS1_uc002sdv.2_Silent_p.L312L|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_Silent_p.L249L|MEIS1_uc002sdw.1_Silent_p.L170L	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	314	Homeobox; TALE-type.						sequence-specific DNA binding transcription factor activity				0						ACACGGGACTCACCATCCTTC	0.423													13	31					0	0	0	0	T	66775128	T	T	66775128	2	4	195	1	0	0	0	0	0	0	0	1	9520	813	29	2		2	MEIS1	2	66775128	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	3557167	66775128	176424245	50	35800											
ASPRV1	151516	broad.mit.edu	37	chr2	70188034	70188034	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttcagcttcagcttgcctaGggacaccgctgtatcccaga	8	10	9	14	1	2	1	2	0	0	1	3	2	3	2	3	1	3	4	3	1	2	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:70188034G>A	uc002sfz.3	-	1	1364	c.787C>T	c.(787-789)CTA>TTA	p.L263L		NM_152792	NP_690005	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1 precursor	263	Peptidase A2.|Extracellular (Potential).				protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			ovary(1)	1						AGCTTGCCTAGGGACACCGCT	0.542													25	60					0	0	0	0	A	70188034	A	A	70188034	2	1	195	1	0	0	0	0	0	0	0	1	1060	991	35	4		4	ASPRV1	2	70188034	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	3412906	70188034	173011339	51	35801											
ZNF638	27332	broad.mit.edu	37	chr2	71653623	71653623	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catttaatttggatgaatttGttactgtggatgaggttata	11	18	10	2	0	0	2	0	2	0	0	0	4	0	4	0	3	1	2	0	3	5	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:71653623G>T	uc002shx.2	+	24	4943	c.4624G>T	c.(4624-4626)GTT>TTT	p.V1542F	ZNF638_uc002shy.2_Missense_Mutation_p.V1542F|ZNF638_uc002shz.2_Missense_Mutation_p.V1542F|ZNF638_uc002sia.2_Missense_Mutation_p.V1542F|ZNF638_uc002sib.1_Missense_Mutation_p.L1133F|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.V639F|ZNF638_uc002sid.2_5'UTR	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1542					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GGATGAATTTGTTACTGTGGA	0.348													18	20					1.56452e-12	2.98049e-12	1	0	T	71653623	T	T	71653623	3	4	195	1	0	0	0	0	1	0	0	0	18122	1377	48	4	4714	4	ZNF638	2	71653623	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1465589	71653623	171545750	52	35802											
REG1B	5968	broad.mit.edu	37	chr2	79314023	79314023	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgccttctgggcagctgattCggggattaggcagctctgtc	5	12	14	10	1	2	1	0	1	2	0	4	2	2	2	1	4	3	4	1	4	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:79314023C>G	uc002sny.2	-	3	210	c.98G>C	c.(97-99)CGA>CCA	p.R33P	REG1B_uc010ffv.1_Missense_Mutation_p.R33P|REG1B_uc010ffw.2_Missense_Mutation_p.R33P	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	33					cell proliferation	extracellular region	sugar binding	p.R33*(1)		central_nervous_system(1)|skin(1)	2						GCAGCTGATTCGGGGATTAGG	0.498													68	53					0	0	0	0	G	79314023	G	G	79314023	3	3	195	1	0	0	0	0	1	0	0	0	13276	884	31	3	418	3	REG1B	2	79314023	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	7660400	79314023	163885350	53	35803											
CTNNA2	1496	broad.mit.edu	37	chr2	79878701	79878701	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcatgacttcggcaacttcaCctatcattctgaaatgggac	11	11	8	11	1	3	2	2	2	1	0	4	3	3	3	1	2	1	2	1	2	3	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:79878701C>T	uc010ysh.1	+	1	24	c.19C>T	c.(19-21)CCT>TCT	p.P7S	CTNNA2_uc010yse.1_Missense_Mutation_p.P7S|CTNNA2_uc010ysf.1_Missense_Mutation_p.P7S|CTNNA2_uc010ysg.1_Missense_Mutation_p.P7S|hsa-mir-4264|MI0015877_5'Flank	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	7					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GGCAACTTCACCTATCATTCT	0.403													24	57					0	0	0	0	T	79878701	T	T	79878701	3	4	195	1	0	0	0	0	1	0	0	0	4030	507	18	4	21	4	CTNNA2	2	79878701	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	564678	79878701	163320672	54	35804											
DPP10	57628	broad.mit.edu	37	chr2	116447315	116447315	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatttacaacatacacactaGgtaagttctttgattttcta	13	16	5	7	0	2	1	0	1	2	0	2	2	2	1	0	1	3	2	0	1	6	10			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:116447315G>A	uc002tla.1	+	6	951	c.494G>A	c.(493-495)AGG>AAG	p.R165K	DPP10_uc002tlb.1_Missense_Mutation_p.R115K|DPP10_uc002tlc.1_Missense_Mutation_p.R161K|DPP10_uc002tle.2_Missense_Mutation_p.R169K|DPP10_uc002tlf.1_Missense_Mutation_p.R158K	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	165	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ATACACACTAGGTAAGTTCTT	0.264													4	16					0	0	0	0	A	116447315	A	A	116447315	3	1	195	1	0	0	0	0	1	0	0	0	4749	1014	35	4	687	4	DPP10	2	116447315	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	36568614	116447315	126752058	55	35805											
LRP1B	53353	broad.mit.edu	37	chr2	141260622	141260622	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccattgagtatttagaaGacaccgcccatcagcacaac	13	8	7	13	1	1	3	1	1	0	2	1	3	1	3	3	0	3	2	3	0	4	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:141260622G>C	uc002tvj.1	-	54	9544	c.8572C>G	c.(8572-8574)CTT>GTT	p.L2858V		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2858	Extracellular (Potential).|LDL-receptor class A 19.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTATTTAGAAGACACCGCCCA	0.388										TSP Lung(27;0.18)			20	52					0	0	0	0	C	141260622	C	C	141260622	3	2	195	1	0	0	0	0	1	0	0	0	9005	942	33	2	5379	2	LRP1B	2	141260622	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	24813307	141260622	101938751	56	35806											
MBD5	55777	broad.mit.edu	37	chr2	149227843	149227843	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agtaacagtccagtccccaaCcaccatcttgcaggtttaat	12	10	6	13	0	1	0	0	0	1	0	3	0	3	0	5	1	3	3	5	1	3	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:149227843C>T	uc002twm.3	+	9	3319	c.2331C>T	c.(2329-2331)AAC>AAT	p.N777N	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Silent_p.N777N|MBD5_uc002twn.1_Silent_p.N218N	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	777						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CAGTCCCCAACCACCATCTTG	0.463													21	63					0	0	0	0	T	149227843	T	T	149227843	2	4	195	1	0	0	0	0	0	0	0	1	9400	506	18	4		4	MBD5	2	149227843	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	7967221	149227843	93971530	57	35807											
NEB	4703	broad.mit.edu	37	chr2	152499769	152499769	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacggtaaacatggtcactCaaaatctgggtggctcgttt	10	12	11	8	2	3	1	2	1	1	0	4	1	3	1	0	4	1	3	0	4	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:152499769C>G	uc010fnx.2	-	58	8246	c.8055G>C	c.(8053-8055)TTG>TTC	p.L2685F		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2685	Nebulin 72.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATGGTCACTCAAAATCTGGG	0.413													3	109					0	0	0	0	G	152499769	G	G	152499769	3	3	195	1	0	0	0	0	1	0	0	0	10356	825	29	2	18131	2	NEB	2	152499769	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	3271926	152499769	90699604	58	35808											
XIRP2	129446	broad.mit.edu	37	chr2	168102261	168102261	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcaatgttaaaacatctacTtggctatttgaaacccacac	14	11	6	10	0	1	1	0	1	1	0	1	1	1	1	1	2	3	3	1	2	6	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:168102261T>G	uc002udx.2	+	8	4377	c.4359T>G	c.(4357-4359)ACT>ACG	p.T1453T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.T1278T|XIRP2_uc010fpq.2_Silent_p.T1231T|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1278	Xin 26.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAACATCTACTTGGCTATTTG	0.348													10	15					0	0	0	0	G	168102261	G	G	168102261	2	3	195	1	0	0	0	0	0	0	0	1	17498	1596	56	5		5	XIRP2	2	168102261	Silent	SNP	T	TCGA-CV-6936-01A-11D-1912-08	15602492	168102261	75097112	59	35809											
GPR155	151556	broad.mit.edu	37	chr2	175346518	175346518	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggcccttcctgctatgtagCcacaaaggacaatgccaaag	12	8	9	12	0	0	0	0	0	0	0	1	1	1	1	4	2	3	2	4	2	5	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:175346518C>G	uc002uit.2	-	3	558	c.167G>C	c.(166-168)GGC>GCC	p.G56A	GPR155_uc002uiu.2_Missense_Mutation_p.G56A|GPR155_uc002uiv.2_Missense_Mutation_p.G56A|GPR155_uc010fqs.2_Missense_Mutation_p.G56A	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	56	Helical; (Potential).				intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						TGCTATGTAGCCACAAAGGAC	0.418													12	34					0	0	0	0	G	175346518	G	G	175346518	3	3	195	1	0	0	0	0	1	0	0	0	6698	739	26	4	2505	4	GPR155	2	175346518	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	7244257	175346518	67852855	60	35810											
TTN	7273	broad.mit.edu	37	chr2	179395647	179395647	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctctggggatttgactcttGgtggtgatgtcacagccttt	5	15	13	8	0	3	2	1	2	2	0	3	3	3	3	1	4	1	1	1	4	0	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:179395647G>T	uc010zfg.1	-	307	98215	c.97991C>A	c.(97990-97992)CCA>CAA	p.P32664Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P26359Q|TTN_uc010zfi.1_Missense_Mutation_p.P26292Q|TTN_uc010zfj.1_Missense_Mutation_p.P26167Q|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33591							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGACTCTTGGTGGTGATGT	0.478													13	141					4.36969e-10	8.15506e-10	1	0	T	179395647	T	T	179395647	3	4	195	1	0	0	0	0	1	0	0	0	16803	1348	47	4	2304	4	TTN	2	179395647	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	4049129	179395647	63803726	61	35811											
TTN	7273	broad.mit.edu	37	chr2	179593094	179593094	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttatccattttggttaatTttttggtgaatgatggagga	9	19	10	3	0	0	2	0	2	0	0	1	4	1	4	1	4	0	1	1	4	3	8			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:179593094T>G	uc010zfg.1	-	64	15949	c.15725A>C	c.(15724-15726)AAA>ACA	p.K5242T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K1903T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6169							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTTAATTTTTTGGTGAA	0.358													6	13					0	0	0	0	G	179593094	G	G	179593094	3	3	195	1	0	0	0	0	1	0	0	0	16803	1841	64	5	85256	5	TTN	2	179593094	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	197447	179593094	63606279	62	35812											
TTN	7273	broad.mit.edu	37	chr2	179654776	179654776	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acctcttgatactaaatcttGttctttgactttgggtgtgg	7	18	9	7	0	3	2	0	2	3	0	3	2	3	2	1	2	1	1	1	2	3	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:179654776G>T	uc010zfg.1	-	12	2091	c.1867C>A	c.(1867-1869)CAA>AAA	p.Q623K	TTN_uc010zfh.1_Missense_Mutation_p.Q577K|TTN_uc010zfi.1_Missense_Mutation_p.Q577K|TTN_uc010zfj.1_Missense_Mutation_p.Q577K|TTN_uc002unb.2_Missense_Mutation_p.Q623K|TTN_uc010frg.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	623							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTAAATCTTGTTCTTTGACT	0.348													18	27					3.51602e-12	6.67835e-12	1	0	T	179654776	T	T	179654776	3	4	195	1	0	0	0	0	1	0	0	0	16803	1386	48	4	109525	4	TTN	2	179654776	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	61682	179654776	63544597	63	35813											
TTN	7273	broad.mit.edu	37	chr2	179655440	179655440	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggaagtcatcaccttttCataacttaggtgcatttgat	11	14	8	8	0	3	1	3	1	0	0	3	2	3	2	1	2	2	2	1	2	3	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:179655440C>T	uc010zfg.1	-	11	2019	c.1795G>A	c.(1795-1797)GAA>AAA	p.E599K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002unb.2_Missense_Mutation_p.E599K|TTN_uc010frg.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	599							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCACCTTTTCATAACTTAGG	0.408													6	82					0	0	0	0	T	179655440	T	T	179655440	3	4	195	1	0	0	0	0	1	0	0	0	16803	835	29	2	109601	2	TTN	2	179655440	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	664	179655440	63543933	64	35814											
PMS1	5378	broad.mit.edu	37	chr2	190719576	190719576	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctgaaaaaagtttaccatgTaaagtaagtaataataatta	20	12	5	4	0	0	1	0	1	0	0	0	1	0	1	2	0	1	4	2	0	11	8			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:190719576T>C	uc002urh.3	+	9	2107	c.1578T>C	c.(1576-1578)TGT>TGC	p.C526C	PMS1_uc010zga.1_Silent_p.C487C|PMS1_uc010zgb.1_Silent_p.C465C|PMS1_uc002urk.3_Silent_p.C487C|PMS1_uc002uri.3_Silent_p.C526C|PMS1_uc010zgc.1_Silent_p.C350C|PMS1_uc010zgd.1_Silent_p.C350C|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Silent_p.C487C|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Silent_p.C311C|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_Silent_p.C194C	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	526					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			GTTTACCATGTAAAGTAAGTA	0.294			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					12	30					0	0	0	0	C	190719576	C	C	190719576	2	2	195	1	0	0	0	0	0	0	0	1	12197	1644	57	5		5	PMS1	2	190719576	Silent	SNP	T	TCGA-CV-6936-01A-11D-1912-08	11064136	190719576	52479797	65	35815											
STAT1	6772	broad.mit.edu	37	chr2	191863005	191863005	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctgttcttgtttctgatCactctttgccacaccattgg	6	16	7	12	0	4	1	1	1	3	0	4	1	4	1	2	1	2	3	2	1	0	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:191863005C>T	uc002usj.2	-	8	959	c.571G>A	c.(571-573)GAT>AAT	p.D191N	STAT1_uc010fse.1_Missense_Mutation_p.D191N|STAT1_uc002usk.2_Missense_Mutation_p.D191N|STAT1_uc002usl.2_Missense_Mutation_p.D193N|STAT1_uc010fsf.1_Intron	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	191					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TGTTTCTGATCACTCTTTGCC	0.338													7	64					0	0	0	0	T	191863005	T	T	191863005	3	4	195	1	0	0	0	0	1	0	0	0	15330	826	29	2	1757	2	STAT1	2	191863005	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	1143429	191863005	51336368	66	35816											
DNAH7	56171	broad.mit.edu	37	chr2	196664153	196664153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtggttcaatgaatgcaCgtcccaatctgttgattata	10	13	11	7	1	2	2	1	2	1	0	3	2	3	2	1	3	1	3	1	3	5	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:196664153C>T	uc002utj.3	-	55	10321	c.10220G>A	c.(10219-10221)CGT>CAT	p.R3407H		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3407	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AATGAATGCACGTCCCAATCT	0.418													28	75					0	0	0	0	T	196664153	T	T	196664153	3	4	195	1	0	0	0	0	1	0	0	0	4628	536	19	1	1898	1	DNAH7	2	196664153	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	4801148	196664153	46535220	67	35817											
GTF3C3	9330	broad.mit.edu	37	chr2	197641315	197641315	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccaccttgccatagctttCagcagctcgctccatatagc	10	10	6	15	1	1	0	1	0	0	0	3	0	2	0	4	0	6	4	4	0	4	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:197641315C>T	uc002uts.2	-	11	1519	c.1429G>A	c.(1429-1431)GAA>AAA	p.E477K	GTF3C3_uc010zgu.1_Missense_Mutation_p.E448K	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	477	TPR 8.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						CCATAGCTTTCAGCAGCTCGC	0.438													5	87					0	0	0	0	T	197641315	T	T	197641315	3	4	195	1	0	0	0	0	1	0	0	0	6913	835	29	2	1263	2	GTF3C3	2	197641315	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	977162	197641315	45558058	68	35818											
FN1	2335	broad.mit.edu	37	chr2	216286886	216286886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacgtgcacctcatcatgtGacccatgtcatgctgcttat	9	12	7	13	1	3	1	3	1	0	0	3	1	3	1	2	0	3	3	2	0	1	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:216286886G>C	uc002vfa.2	-	10	1740	c.1474C>G	c.(1474-1476)CAC>GAC	p.H492D	FN1_uc002vfb.2_Missense_Mutation_p.H492D|FN1_uc002vfc.2_Missense_Mutation_p.H492D|FN1_uc002vfd.2_Missense_Mutation_p.H492D|FN1_uc002vfe.2_Missense_Mutation_p.H492D|FN1_uc002vff.2_Missense_Mutation_p.H492D|FN1_uc002vfg.2_Missense_Mutation_p.H492D|FN1_uc002vfh.2_Missense_Mutation_p.H492D|FN1_uc002vfi.2_Missense_Mutation_p.H492D|FN1_uc002vfj.2_Missense_Mutation_p.H492D|FN1_uc002vfl.2_Missense_Mutation_p.H492D	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	492	Collagen-binding.|Fibronectin type-I 7.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCATCATGTGACCCATGTCA	0.478													21	100					0	0	0	0	C	216286886	C	C	216286886	3	2	195	1	0	0	0	0	1	0	0	0	5994	1290	45	2	6140	2	FN1	2	216286886	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	18645571	216286886	26912487	69	35819											
SP140	11262	broad.mit.edu	37	chr2	231112644	231112644	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccctagttctagaaagcaaCgggatgatagatgcggcaag	13	8	12	8	2	1	3	0	1	1	2	2	4	2	4	1	2	3	3	1	2	6	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:231112644C>T	uc002vql.2	+	8	871	c.756C>T	c.(754-756)AAC>AAT	p.N252N	SP140_uc010zma.1_Intron|SP140_uc002vqk.2_Silent_p.N252N|SP140_uc002vqn.2_Intron|SP140_uc002vqm.2_Silent_p.N226N|SP140_uc010fxl.2_Silent_p.N252N	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	252					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TAGAAAGCAACGGGATGATAG	0.443													32	70					0	0	0	0	T	231112644	T	T	231112644	2	4	195	1	0	0	0	0	0	0	0	1	15026	535	19	1		1	SP140	2	231112644	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	14825758	231112644	12086729	70	35820											
GBX2	2637	broad.mit.edu	37	chr2	237075004	237075004	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagtccacatcgctctccagCgagaagctctcctccttgcc	7	10	7	17	2	2	1	0	0	2	1	7	2	4	1	5	0	3	2	5	0	2	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr2:237075004C>A	uc002vvw.1	-	2	638	c.600G>T	c.(598-600)TCG>TCT	p.S200S	GBX2_uc010zng.1_Missense_Mutation_p.A203S	NM_001485	NP_001476	P52951	GBX2_HUMAN	gastrulation brain homeo box 2	200						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		CGCTCTCCAGCGAGAAGCTCT	0.602													39	79					2.75727e-19	5.34794e-19	1	0	A	237075004	A	A	237075004	2	1	195	1	0	0	0	0	0	0	0	1	6316	755	27	3		3	GBX2	2	237075004	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	5962360	237075004	6124369	71	35821											
LRRN1	57633	broad.mit.edu	37	chr3	3888390	3888390	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caccactcattaacctctggGaaggtgacagcgagaaagac	14	6	10	11	1	2	3	1	1	1	2	2	5	2	4	2	2	2	0	2	2	3	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:3888390G>T	uc003bpt.3	+	2	2826	c.2065G>T	c.(2065-2067)GAA>TAA	p.E689*	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	689	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TAACCTCTGGGAAGGTGACAG	0.413													19	9					2.35188e-11	4.42788e-11	1	0	T	3888390	T	T	3888390	4	4	195	1	0	0	0	0	0	1	0	0	9084	1175	41	2	2067	2	LRRN1	3	3888390	Nonsense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08		3888390	194134040	72	35822											
HACL1	26061	broad.mit.edu	37	chr3	15609959	15609959	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgacgaggaaggtagttCtgaagcacagtccgtccaat	11	9	12	9	2	1	2	0	2	1	0	3	4	3	3	2	2	1	3	2	2	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:15609959C>T	uc003caf.2	-	13	1390	c.1230G>A	c.(1228-1230)CAG>CAA	p.Q410Q	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Silent_p.Q383Q|HACL1_uc011avt.1_Silent_p.Q350Q|HACL1_uc003cag.2_Silent_p.Q54Q|HACL1_uc011avu.1_Silent_p.Q328Q|HACL1_uc010hep.2_Silent_p.Q169Q	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	410	Thiamine pyrophosphate binding.				fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						GAAGGTAGTTCTGAAGCACAG	0.368													5	40					0	0	0	0	T	15609959	T	T	15609959	2	4	195	1	0	0	0	0	0	0	0	1	6980	912	32	2		2	HACL1	3	15609959	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	11721569	15609959	182412471	73	35823											
TGFBR2	7048	broad.mit.edu	37	chr3	30713698	30713698	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtacctgacgcggcatgtCatcagctgggaggacctgcg	8	7	15	11	3	2	1	2	1	0	0	2	4	2	3	2	3	3	3	2	3	1	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:30713698C>T	uc003ceo.2	+	4	1405	c.1023C>T	c.(1021-1023)GTC>GTT	p.V341V	TGFBR2_uc003cen.2_Silent_p.V366V	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	341	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CGCGGCATGTCATCAGCTGGG	0.617													52	40					0	0	0	0	T	30713698	T	T	30713698	2	4	195	1	0	0	0	0	0	0	0	1	15888	813	29	2		2	TGFBR2	3	30713698	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	15103739	30713698	167308732	74	35824											
MLH1	4292	broad.mit.edu	37	chr3	37048548	37048548	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctggcaatcaagggacccaGatcacggtaagaatggtaca	14	6	12	9	1	2	2	2	0	0	2	2	3	2	3	1	4	1	4	1	4	5	2	rs63750638		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:37048548G>A	uc003cgl.2	+	5	507	c.447G>A	c.(445-447)CAG>CAA	p.Q149Q	MLH1_uc011aye.1_5'UTR|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Silent_p.Q149Q|MLH1_uc003cgn.3_5'UTR|MLH1_uc011ayc.1_Silent_p.Q51Q|MLH1_uc011ayd.1_5'UTR|MLH1_uc003cgo.2_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	149					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						AAGGGACCCAGATCACGGTAA	0.343		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				22	15					0	0	0	0	A	37048548	A	A	37048548	2	1	195	1	0	0	0	0	0	0	0	1	9670	933	33	2		2	MLH1	3	37048548	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	6334850	37048548	160973882	75	35825											
DLEC1	9940	broad.mit.edu	37	chr3	38081086	38081086	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgatcaaggcccgcggcagcGagaatgagcgccacgaggag	11	3	16	11	5	1	3	1	2	0	1	1	6	1	4	2	3	2	1	2	3	2	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:38081086G>A	uc003cho.1	+	1	391	c.370G>A	c.(370-372)GAG>AAG	p.E124K	DLEC1_uc003chp.1_Missense_Mutation_p.E124K|DLEC1_uc010hgv.1_Missense_Mutation_p.E124K	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	124					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CCGCGGCAGCGAGAATGAGCG	0.647													23	39					0	0	0	0	A	38081086	A	A	38081086	3	1	195	1	0	0	0	0	1	0	0	0	4574	1059	37	1	372	1	DLEC1	3	38081086	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1032538	38081086	159941344	76	35826											
TTC21A	199223	broad.mit.edu	37	chr3	39156090	39156090	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacaggcaatgtacttcatGatgcagcagaactactcaga	15	8	8	10	0	2	3	2	1	0	2	2	3	2	3	0	1	6	4	0	1	5	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:39156090G>A	uc003cjc.2	+	6	750	c.573G>A	c.(571-573)ATG>ATA	p.M191I	TTC21A_uc003cja.2_Missense_Mutation_p.M191I|TTC21A_uc010hho.1_Missense_Mutation_p.M113I|TTC21A_uc003cjb.2_Missense_Mutation_p.D58N|TTC21A_uc003cje.2_Missense_Mutation_p.M191I|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.M150I	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	191	TPR 4.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TGTACTTCATGATGCAGCAGA	0.557													62	57					0	0	0	0	A	39156090	A	A	39156090	3	1	195	1	0	0	0	0	1	0	0	0	16755	1290	45	2	595	2	TTC21A	3	39156090	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1075004	39156090	158866340	77	35827											
ALS2CL	259173	broad.mit.edu	37	chr3	46713495	46713495	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtatgtcctctccagcacctCcagcttctcccgtgggtcca	5	11	8	17	1	2	0	0	0	2	0	7	0	5	0	6	1	2	3	6	1	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:46713495C>G	uc003cqa.1	-	24	2753	c.2563G>C	c.(2563-2565)GAG>CAG	p.E855Q	ALS2CL_uc003cpx.1_Missense_Mutation_p.E202Q|ALS2CL_uc003cpy.1_RNA|ALS2CL_uc003cpz.1_Missense_Mutation_p.E370Q|ALS2CL_uc003cqb.1_Missense_Mutation_p.E855Q|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	855	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		TCCAGCACCTCCAGCTTCTCC	0.622													3	50					0	0	0	0	G	46713495	G	G	46713495	3	3	195	1	0	0	0	0	1	0	0	0	551	864	30	2	310	2	ALS2CL	3	46713495	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	7557405	46713495	151308935	78	35828											
NBEAL2	23218	broad.mit.edu	37	chr3	47033992	47033992	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcagtcccgggcgccccccGagggggacagtgacctggct	5	5	16	15	3	0	1	0	1	0	0	1	3	1	2	5	4	1	2	5	4	0	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:47033992G>A	uc003cqp.2	+	10	1239	c.1060G>A	c.(1060-1062)GAG>AAG	p.E354K	NBEAL2_uc003cqq.1_Intron|NBEAL2_uc010hjm.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	354							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GGCGCCCCCCGAGGGGGACAG	0.637													5	4					0	0	0	0	A	47033992	A	A	47033992	3	1	195	1	0	0	0	0	1	0	0	0	10242	1059	37	1	1098	1	NBEAL2	3	47033992	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	320497	47033992	150988438	79	35829											
CCDC36	339834	broad.mit.edu	37	chr3	49294689	49294689	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctctatgacctgggttttGatagcagtgatgatgatggc	8	14	13	6	0	1	5	0	5	1	0	1	5	1	5	1	2	2	3	1	2	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:49294689G>C	uc003cwk.2	+	10	2146	c.1759G>C	c.(1759-1761)GAT>CAT	p.D587H	CCDC36_uc011bck.1_Missense_Mutation_p.D587H	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	587										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CCTGGGTTTTGATAGCAGTGA	0.478													3	162					0	0	0	0	C	49294689	C	C	49294689	3	2	195	1	0	0	0	0	1	0	0	0	2821	1290	45	2	1785	2	CCDC36	3	49294689	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	2260697	49294689	148727741	80	35830											
RBM5	10181	broad.mit.edu	37	chr3	50151488	50151488	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagggaagaagaaaggagaGaatctgctgcagcagacgct	15	5	15	6	1	1	5	0	1	1	4	1	8	1	7	0	2	3	4	0	2	4	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:50151488G>C	uc003cyg.2	+	19	1871	c.1723G>C	c.(1723-1725)GAA>CAA	p.E575Q	RBM5_uc011bdj.1_Missense_Mutation_p.E519Q|RBM5_uc011bdk.1_Missense_Mutation_p.E403Q|RBM5_uc003cyh.2_Missense_Mutation_p.E32Q	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	575	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGAAAGGAGAGAATCTGCTGC	0.423													22	24					0	0	0	0	C	50151488	C	C	50151488	3	2	195	1	0	0	0	0	1	0	0	0	13208	943	33	2	1793	2	RBM5	3	50151488	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	856799	50151488	147870942	81	35831											
GRM2	2912	broad.mit.edu	37	chr3	51749374	51749374	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcattccgtgccagccctatGagtaccgattggacgaattc	9	10	10	12	3	0	1	0	1	0	0	2	4	1	2	4	1	3	2	4	1	3	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:51749374G>C	uc010hlv.2	+	4	1824	c.1585G>C	c.(1585-1587)GAG>CAG	p.E529Q	GRM2_uc003dbo.3_5'UTR|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	529	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CCAGCCCTATGAGTACCGATT	0.612													6	15					0	0	0	0	C	51749374	C	C	51749374	3	2	195	1	0	0	0	0	1	0	0	0	6836	1291	45	2	1595	2	GRM2	3	51749374	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1597886	51749374	146273056	82	35832											
SFMBT1	51460	broad.mit.edu	37	chr3	52947576	52947576	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttgttaagatatggccctGagaagcaacggtggttgaag	11	11	13	6	1	0	3	0	2	0	2	0	4	0	3	1	3	2	3	1	3	5	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:52947576G>C	uc003dgf.2	-	16	2107	c.1538C>G	c.(1537-1539)TCA>TGA	p.S513*	SFMBT1_uc010hmr.2_Nonsense_Mutation_p.S460*|SFMBT1_uc003dgg.2_Nonsense_Mutation_p.S513*|SFMBT1_uc003dgh.2_Nonsense_Mutation_p.S513*	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	513					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		ATATGGCCCTGAGAAGCAACG	0.403													13	11					0	0	0	0	C	52947576	C	C	52947576	4	2	195	1	0	0	0	0	0	1	0	0	14222	1294	45	2	1090	2	SFMBT1	3	52947576	Nonsense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1198202	52947576	145074854	83	35833											
ERC2	26059	broad.mit.edu	37	chr3	55984515	55984515	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgcacttcttctagtaactGagcatttttcttcttttcca	7	18	5	11	1	4	1	0	1	4	0	5	1	5	1	1	0	2	3	1	0	2	9			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:55984515G>A	uc003dhr.1	-	13	2597	c.2341C>T	c.(2341-2343)CAG>TAG	p.Q781*	ERC2_uc003dhq.1_RNA|ERC2_uc003dht.1_Nonsense_Mutation_p.Q260*	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	781	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TCTAGTAACTGAGCATTTTTC	0.428													10	35					0	0	0	0	A	55984515	A	A	55984515	4	1	195	1	0	0	0	0	0	1	0	0	5235	1299	45	2	552	2	ERC2	3	55984515	Nonsense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	3036939	55984515	142037915	84	35834											
COL8A1	1295	broad.mit.edu	37	chr3	99513335	99513335	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggggatcccaggaccacaagGacctccagggcctcatggac	10	4	13	14	0	1	0	1	0	0	0	3	4	3	4	5	6	0	0	5	6	1	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:99513335G>A	uc003dtg.1	+	5	835	c.590G>A	c.(589-591)GGA>GAA	p.G197E	COL8A1_uc003dth.1_Missense_Mutation_p.G197E|COL8A1_uc003dti.1_Missense_Mutation_p.G198E	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	197	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						GGACCACAAGGACCTCCAGGG	0.587													5	58					0	0	0	0	A	99513335	A	A	99513335	3	1	195	1	0	0	0	0	1	0	0	0	3720	1174	41	2	596	2	COL8A1	3	99513335	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	43528820	99513335	98509095	85	35835											
TFG	10342	broad.mit.edu	37	chr3	100463757	100463758	+	Frame_Shift_Ins	INS	-	A	A																															acctcagcagcctcaacagtINSatggtattcagtattcaggt																										TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:100463757_100463758insA	uc003due.2	+	7	1251_1252	c.802_803insA	c.(802-804)TATfs	p.Y268fs	TFG_uc003duf.2_Frame_Shift_Ins_p.Y268fs|TFG_uc003dug.2_Frame_Shift_Ins_p.Y264fs|TFG_uc003duh.2_Frame_Shift_Ins_p.Y264fs|TFG_uc003dui.2_Frame_Shift_Ins_p.Y268fs	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	268					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						GCCTCAACAGTATGGTATTCAG	0.455			T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								---	---	---								A	100463758	A	A	100463757	7	5	195	1	0	1	1	0	0	0	0	0	15872	1638	57	0	824	0	TFG	3	100463757	Frame_Shift_Ins	INS	-	TCGA-CV-6936-01A-11D-1912-08	950422	100463757	97558673	86	35836											
BOC	91653	broad.mit.edu	37	chr3	112998239	112998239	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagaaagtgggagactggAttctggccaccagcgccatc	12	7	12	10	1	1	2	0	0	1	2	2	4	1	3	3	3	1	0	3	3	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:112998239A>T	uc003dzx.2	+	12	2578	c.1957A>T	c.(1957-1959)ATT>TTT	p.I653F	BOC_uc003dzy.2_Missense_Mutation_p.I653F|BOC_uc003dzz.2_Missense_Mutation_p.I654F|BOC_uc003eab.2_Missense_Mutation_p.I354F|BOC_uc003eac.2_5'Flank	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	653	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GGGAGACTGGATTCTGGCCAC	0.602													9	47					0	0	0	0	T	112998239	T	T	112998239	3	4	195	1	0	0	0	0	1	0	0	0	1484	333	12	5	1995	5	BOC	3	112998239	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	12534482	112998239	85024191	87	35837											
CD80	941	broad.mit.edu	37	chr3	119248769	119248769	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgggagcaggttatcaggaAaatgctcttgcttggctatg	10	12	13	6	0	2	0	1	0	1	0	2	2	2	2	0	4	3	5	0	4	4	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:119248769A>T	uc003ecq.2	-	5	1111	c.716T>A	c.(715-717)TTT>TAT	p.F239Y	CD80_uc010hqt.1_Intron|CD80_uc010hqu.1_Intron	NM_005191	NP_005182	P33681	CD80_HUMAN	CD80 antigen precursor	239	Extracellular (Potential).				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2					Abatacept(DB01281)	GTTATCAGGAAAATGCTCTTG	0.408													5	61					0	0	0	0	T	119248769	T	T	119248769	3	4	195	1	0	0	0	0	1	0	0	0	3053	14	1	5	158	5	CD80	3	119248769	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	6250530	119248769	78773661	88	35838											
NDUFB4	4710	broad.mit.edu	37	chr3	120315376	120315376	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtacaacgatcccaaccgccGagggctcatcgtgagtgtgg	9	7	13	12	4	1	1	1	1	0	0	3	3	2	1	3	2	3	2	3	2	3	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:120315376G>A	uc003edu.2	+	1	249	c.170G>A	c.(169-171)CGA>CAA	p.R57Q	NDUFB4_uc003edt.2_Missense_Mutation_p.R57Q	NM_004547	NP_004538	O95168	NDUB4_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	57					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0				GBM - Glioblastoma multiforme(114;0.14)	NADH(DB00157)	CCCAACCGCCGAGGGCTCATC	0.632													4	17					0	0	0	0	A	120315376	A	A	120315376	3	1	195	1	0	0	0	0	1	0	0	0	10337	1058	37	1	172	1	NDUFB4	3	120315376	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1066607	120315376	77707054	89	35839											
GOLGB1	2804	broad.mit.edu	37	chr3	121414936	121414936	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgttgctttgctctactttcTtctccaatctcttctggttt	3	22	5	11	0	5	0	0	0	5	0	7	0	5	0	1	1	3	4	1	1	2	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:121414936T>C	uc003eei.3	-	13	4545	c.4419A>G	c.(4417-4419)GAA>GAG	p.E1473E	GOLGB1_uc010hrc.2_Silent_p.E1478E|GOLGB1_uc003eej.3_Silent_p.E1439E|GOLGB1_uc011bjm.1_Silent_p.E1359E|GOLGB1_uc010hrd.1_Silent_p.E1437E	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1473	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		CTCTACTTTCTTCTCCAATCT	0.393													42	223					0	0	0	0	C	121414936	C	C	121414936	2	2	195	1	0	0	0	0	0	0	0	1	6602	1606	56	5		5	GOLGB1	3	121414936	Silent	SNP	T	TCGA-CV-6936-01A-11D-1912-08	1099560	121414936	76607494	90	35840											
TMEM22	80723	broad.mit.edu	37	chr3	136573801	136573801	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacccagtggatacagattaCgactcttcttttatggtgta	10	14	9	8	1	2	1	0	0	2	1	2	4	2	2	1	2	2	1	1	2	4	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:136573801C>T	uc003erf.3	+	2	713	c.499C>T	c.(499-501)CGA>TGA	p.R167*	TMEM22_uc003erg.3_Nonsense_Mutation_p.R167*|TMEM22_uc010hub.2_Nonsense_Mutation_p.R167*	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	167	DUF6 1.					Golgi apparatus|integral to membrane				ovary(1)	1						ATACAGATTACGACTCTTCTT	0.408													34	160					0	0	0	0	T	136573801	T	T	136573801	4	4	195	1	0	0	0	0	0	1	0	0	16209	528	19	1	501	1	TMEM22	3	136573801	Nonsense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	15158865	136573801	61448629	91	35841											
AGTR1	185	broad.mit.edu	37	chr3	148459339	148459339	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgaaatgtatttttcattGagaacaccaatattacagtt	15	15	5	6	1	1	1	1	1	0	1	2	3	1	1	1	0	2	2	1	0	6	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:148459339G>A	uc003ewg.2	+	4	963	c.517G>A	c.(517-519)GAG>AAG	p.E173K	AGTR1_uc003ewh.2_Missense_Mutation_p.E173K|AGTR1_uc003ewi.2_Missense_Mutation_p.E173K|AGTR1_uc003ewj.2_Missense_Mutation_p.E173K|AGTR1_uc003ewk.2_Missense_Mutation_p.E173K	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	173	Extracellular (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	ATTTTTCATTGAGAACACCAA	0.443													25	85					0	0	0	0	A	148459339	A	A	148459339	3	1	195	1	0	0	0	0	1	0	0	0	401	1291	45	2	519	2	AGTR1	3	148459339	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	11885538	148459339	49563091	92	35842											
VEPH1	79674	broad.mit.edu	37	chr3	157146114	157146114	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacaatgtactttttacctcGagttgttttttctttgctgc	6	21	6	8	1	1	0	0	0	1	0	2	1	1	0	1	0	5	4	1	0	4	10			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:157146114G>A	uc003fbj.1	-	5	1010	c.693C>T	c.(691-693)CTC>CTT	p.L231L	VEPH1_uc003fbk.1_Silent_p.L231L|VEPH1_uc010hvu.1_Silent_p.L231L	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	231						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TTTTTACCTCGAGTTGTTTTT	0.438													6	69					0	0	0	0	A	157146114	A	A	157146114	2	1	195	1	0	0	0	0	0	0	0	1	17222	1045	37	1		1	VEPH1	3	157146114	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	8686775	157146114	40876316	93	35843											
IFT80	57560	broad.mit.edu	37	chr3	160099354	160099354	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctttacacccaaactttttgGaaaccagtgaaaatcaatag	16	11	5	9	0	1	1	1	1	0	0	1	2	1	2	2	1	3	0	2	1	7	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:160099354G>A	uc011boy.1	-	3	629	c.196C>T	c.(196-198)CCA>TCA	p.P66S	IFT80_uc003fda.2_Intron|IFT80_uc003fdb.1_5'UTR|IFT80_uc003fdd.1_5'UTR|IFT80_uc003fde.1_5'UTR	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	66						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AAACTTTTTGGAAACCAGTGA	0.358													9	51					0	0	0	0	A	160099354	A	A	160099354	3	1	195	1	0	0	0	0	1	0	0	0	7603	1174	41	2	2209	2	IFT80	3	160099354	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	2953240	160099354	37923076	94	35844											
ABCC5	10057	broad.mit.edu	37	chr3	183707045	183707045	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggatgggcttcagagcacTcaagccatgatggtactttc	9	10	11	11	1	2	2	2	1	0	1	3	3	2	3	2	3	3	3	2	3	2	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr3:183707045T>C	uc003fmg.2	-	3	421	c.256A>G	c.(256-258)AGT>GGT	p.S86G	ABCC5_uc011bqt.1_5'UTR|ABCC5_uc010hxl.2_Missense_Mutation_p.S86G|ABCC5_uc003fmh.2_Missense_Mutation_p.S86G|ABCC5_uc010hxm.2_RNA|ABCC5_uc010hxn.2_Missense_Mutation_p.S86G|ABCC5_uc010hxo.2_Missense_Mutation_p.S86G	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	86						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TTCAGAGCACTCAAGCCATGA	0.473													28	17					0	0	0	0	C	183707045	C	C	183707045	3	2	195	1	0	0	0	0	1	0	0	0	56	1551	54	5	4209	5	ABCC5	3	183707045	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	23607691	183707045	14315385	95	35845											
BOD1L	259282	broad.mit.edu	37	chr4	13603813	13603813	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accaacatgaagaggattatTtctggaatgtgttcctatta	13	14	8	6	0	1	2	0	1	1	1	2	4	2	4	2	2	1	1	2	2	6	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:13603813T>A	uc003gmz.1	-	10	4828	c.4711A>T	c.(4711-4713)AAT>TAT	p.N1571Y	BOD1L_uc010idr.1_Missense_Mutation_p.N908Y	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1571							DNA binding			ovary(5)|breast(1)	6						AGAGGATTATTTCTGGAATGT	0.468													5	19					0	0	0	0	A	13603813	A	A	13603813	3	1	195	1	0	0	0	0	1	0	0	0	1486	1841	64	5	4512	5	BOD1L	4	13603813	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08		13603813	177550463	96	35846											
GPR125	166647	broad.mit.edu	37	chr4	22517230	22517230	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgcacaccaccttgccctCggcggcgcccgccgccctgc	3	5	11	22	5	0	0	0	0	0	0	1	0	0	0	6	2	3	2	6	2	0	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:22517230C>T	uc003gqm.1	-	1	443	c.178G>A	c.(178-180)GAG>AAG	p.E60K	GPR125_uc003gqo.2_Missense_Mutation_p.E60K	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	60	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				ACCTTGCCCTCGGCGGCGCCC	0.572													11	11					0	0	0	0	T	22517230	T	T	22517230	3	4	195	1	0	0	0	0	1	0	0	0	6677	893	31	1	3863	1	GPR125	4	22517230	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	8913417	22517230	168637046	97	35847											
PDS5A	23244	broad.mit.edu	37	chr4	39843630	39843630	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataatcctcacagggttctCttcattttcactaactccag	11	14	4	12	0	4	0	3	0	1	0	7	0	6	0	2	1	1	1	2	1	3	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:39843630C>G	uc003guv.3	-	31	4135	c.3595G>C	c.(3595-3597)GAG>CAG	p.E1199Q	PDS5A_uc010ifo.2_Missense_Mutation_p.E1159Q	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	1199					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						ACAGGGTTCTCTTCATTTTCA	0.343													4	41					0	0	0	0	G	39843630	G	G	39843630	3	3	195	1	0	0	0	0	1	0	0	0	11745	922	32	2	430	2	PDS5A	4	39843630	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	17326400	39843630	151310646	98	35848											
DCAF4L1	285429	broad.mit.edu	37	chr4	41984115	41984115	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctccaagtacggcatcatCagcctgcgaactctgaagat	11	8	10	12	2	3	2	2	1	1	1	4	3	4	2	2	2	4	3	2	2	4	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:41984115C>T	uc003gwk.2	+	1	403	c.306C>T	c.(304-306)ATC>ATT	p.I102I		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	102										skin(1)	1						ACGGCATCATCAGCCTGCGAA	0.557													17	42					0	0	0	0	T	41984115	T	T	41984115	2	4	195	1	0	0	0	0	0	0	0	1	4288	816	29	2		2	DCAF4L1	4	41984115	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	2140485	41984115	149170161	99	35849											
SHISA3	152573	broad.mit.edu	37	chr4	42403210	42403210	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatgatcctgacctccacCagccccagggcaccctcccg	7	5	7	22	1	0	2	0	2	0	0	3	2	3	2	9	1	1	1	9	1	0	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:42403210C>G	uc003gwp.2	+	2	677	c.459C>G	c.(457-459)ACC>ACG	p.T153T		NM_001080505	NP_001073974	A0PJX4	SHSA3_HUMAN	shisa homolog 3 precursor	153	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|skin(1)	2						TGACCTCCACCAGCCCCAGGG	0.647													30	108					0	0	0	0	G	42403210	G	G	42403210	2	3	195	1	0	0	0	0	0	0	0	1	14346	581	21	4		4	SHISA3	4	42403210	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	419095	42403210	148751066	100	35850											
CHIC2	26511	broad.mit.edu	37	chr4	54880271	54880271	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcccattctaataacttctCaatcgatcttcgtgtctgga	9	16	5	11	2	4	0	1	0	4	0	8	2	5	1	1	1	1	0	1	1	3	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:54880271C>T	uc003haj.1	-	4	667	c.346G>A	c.(346-348)GAG>AAG	p.E116K	PDGFRA_uc003haa.2_Intron	NM_012110	NP_036242	Q9UKJ5	CHIC2_HUMAN	cysteine-rich hydrophobic domain 2	116						plasma membrane	protein binding			central_nervous_system(1)	1	all_cancers(7;0.0193)|all_neural(26;0.0209)|Lung NSC(11;0.0281)|Glioma(25;0.08)		LUSC - Lung squamous cell carcinoma(32;0.00216)			AATAACTTCTCAATCGATCTT	0.403			T	ETV6	AML								10	19					0	0	0	0	T	54880271	T	T	54880271	3	4	195	1	0	0	0	0	1	0	0	0	3359	835	29	2	163	2	CHIC2	4	54880271	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	12477061	54880271	136274005	101	35851											
POLR2B	5431	broad.mit.edu	37	chr4	57896492	57896492	+	Frame_Shift_Del	DEL	T	-	-																															tcaggttcatgtttgcaatcTttgtggaataatggcgattg																										TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:57896492delT	uc003hcl.1	+	24	3405	c.3362delT	c.(3361-3363)CTTfs	p.L1121fs	POLR2B_uc011cae.1_Frame_Shift_Del_p.L1114fs|POLR2B_uc011caf.1_Frame_Shift_Del_p.L1046fs|POLR2B_uc003hcm.1_Frame_Shift_Del_p.L614fs	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	1121	C4-type.				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					GTTTGCAATCTTTGTGGAATA	0.448													---	---	---								-	57896492	-	-	57896492	7	5	195	1	0	1	0	1	0	0	0	0	12270	1609	56	0	3456	0	POLR2B	4	57896492	Frame_Shift_Del	DEL	T	TCGA-CV-6936-01A-11D-1912-08	3016221	57896492	133257784	102	35852											
TMPRSS11F	389208	broad.mit.edu	37	chr4	68925156	68925156	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtgcttatggtttccactCtggcttgccgaagtgtattt	6	16	10	9	1	1	0	0	0	1	0	2	1	2	0	2	2	2	4	2	2	3	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:68925156C>G	uc003hdt.1	-	9	1095	c.1046G>C	c.(1045-1047)AGA>ACA	p.R349T	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	349	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GGTTTCCACTCTGGCTTGCCG	0.358													12	21					0	0	0	0	G	68925156	G	G	68925156	3	3	195	1	0	0	0	0	1	0	0	0	16309	913	32	2	278	2	TMPRSS11F	4	68925156	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	11028664	68925156	122229120	103	35853											
COL25A1	84570	broad.mit.edu	37	chr4	109895698	109895698	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattttcttaccttatcgccTtttggaccaggagggccctg	6	14	9	12	1	1	0	0	0	1	0	2	2	1	2	4	3	1	0	4	3	2	6	rs142155024	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr4:109895698T>C	uc003hze.1	-	6	987	c.456A>G	c.(454-456)AAA>AAG	p.K152K	COL25A1_uc003hzg.2_Silent_p.K152K|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_5'UTR	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	152	Extracellular (Potential).|Collagen-like 1.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CCTTATCGCCTTTTGGACCAG	0.318													3	121					0	0	0	0	C	109895698	C	C	109895698	2	2	195	1	0	0	0	0	0	0	0	1	3699	1606	56	5		5	COL25A1	4	109895698	Silent	SNP	T	TCGA-CV-6936-01A-11D-1912-08	40970542	109895698	81258578	104	35854											
NDST4	64579	broad.mit.edu	37	chr4	115769459	115769459	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gagattgctgatgattgaagGatgcataagaagaaataaat	18	10	11	2	0	0	6	0	3	0	3	0	8	0	7	0	1	2	2	0	1	6	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:115769459G>C	uc003ibu.2	-	9	2531	c.1852C>G	c.(1852-1854)CCT>GCT	p.P618A	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	618	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATGATTGAAGGATGCATAAGA	0.308													4	60					0	0	0	0	C	115769459	C	C	115769459	3	2	195	1	0	0	0	0	1	0	0	0	10312	1174	41	2	790	2	NDST4	4	115769459	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	5873761	115769459	75384817	105	35855											
QRFPR	84109	broad.mit.edu	37	chr4	122250496	122250496	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactgtctaaaggagaattCtcagccagttcagacctaaa	14	9	7	11	0	3	2	2	0	2	2	4	3	3	2	3	1	1	1	3	1	5	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:122250496C>A	uc010inj.1	-	6	1648	c.1269G>T	c.(1267-1269)GAG>GAT	p.E423D	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_3'UTR	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	423	Cytoplasmic (Potential).					plasma membrane	neuropeptide Y receptor activity				0						AAGGAGAATTCTCAGCCAGTT	0.368													23	55					1.10513e-12	2.11159e-12	1	0	A	122250496	A	A	122250496	3	1	195	1	0	0	0	0	1	0	0	0	12943	912	32	2	30	2	QRFPR	4	122250496	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	6481037	122250496	68903780	106	35856											
HPGD	3248	broad.mit.edu	37	chr4	175414436	175414436	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggacaaatggcattcagtctCacaccactgttcataagatt	13	11	7	10	0	3	1	3	0	1	1	4	2	3	2	1	2	0	2	1	2	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:175414436C>T	uc003itu.2	-	6	718	c.528G>A	c.(526-528)GTG>GTA	p.V176V	HPGD_uc003itt.2_Silent_p.V43V|HPGD_uc003itv.2_Intron|HPGD_uc011ckf.1_Silent_p.V55V|HPGD_uc010irp.2_Silent_p.V55V|HPGD_uc010irq.2_Intron|HPGD_uc011ckg.1_Silent_p.V108V|HPGD_uc011ckh.1_Silent_p.V55V	NM_000860	NP_000851	P15428	PGDH_HUMAN	hydroxyprostaglandin dehydrogenase 15-(NAD)	176					female pregnancy|lipoxygenase pathway|negative regulation of cell cycle|parturition|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|NAD+ binding|prostaglandin E receptor activity|protein homodimerization activity				0		Prostate(90;0.00763)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;2.6e-18)|Epithelial(43;4.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.23e-09)|GBM - Glioblastoma multiforme(59;0.00176)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.0253)	NADH(DB00157)	CATTCAGTCTCACACCACTGT	0.363													9	45					0	0	0	0	T	175414436	T	T	175414436	2	4	195	1	0	0	0	0	0	0	0	1	7373	813	29	2		2	HPGD	4	175414436	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	53163940	175414436	15739840	107	35857											
ADAM29	11086	broad.mit.edu	37	chr4	175897135	175897135	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctggtatacaagatggaCagtgaggagaaacaattttc	15	10	10	6	0	1	3	0	1	1	2	2	5	1	4	0	3	2	1	0	3	5	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:175897135C>T	uc003iuc.2	+	5	1129	c.459C>T	c.(457-459)GAC>GAT	p.D153D	ADAM29_uc003iud.2_Silent_p.D153D|ADAM29_uc010irr.2_Silent_p.D153D|ADAM29_uc011cki.1_Silent_p.D153D	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	153					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ACAAGATGGACAGTGAGGAGA	0.363													19	67					0	0	0	0	T	175897135	T	T	175897135	2	4	195	1	0	0	0	0	0	0	0	1	247	477	17	4		4	ADAM29	4	175897135	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	482699	175897135	15257141	108	35858											
SNX25	83891	broad.mit.edu	37	chr4	186231908	186231908	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaatccgaatcctgggaggcCctgcctatgaccagcaagag	11	6	12	12	1	0	2	0	1	0	1	2	5	2	3	5	2	2	1	5	2	4	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:186231908C>A	uc003ixh.2	+	7	979	c.790C>A	c.(790-792)CCT>ACT	p.P264T	SNX25_uc010ish.2_Missense_Mutation_p.P35T	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	264					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CCTGGGAGGCCCTGCCTATGA	0.512													14	80					4.14922e-12	7.85781e-12	1	0	A	186231908	A	A	186231908	3	1	195	1	0	0	0	0	1	0	0	0	14960	623	22	4	812	4	SNX25	4	186231908	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	10334773	186231908	4922368	109	35859											
ANKRD37	353322	broad.mit.edu	37	chr4	186318369	186318369	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcacccccggatccctgcaaGcagtcgcctgtccacttagc	7	7	9	18	2	0	0	0	0	0	0	3	1	2	1	5	1	3	3	5	1	2	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:186318369G>A	uc003ixm.2	+	2	331	c.93G>A	c.(91-93)AAG>AAA	p.K31K	LRP2BP_uc011ckr.1_5'Flank|ANKRD37_uc011cks.1_Silent_p.K31K	NM_181726	NP_859077	Q7Z713	ANR37_HUMAN	ankyrin repeat domain 37	31	ANK 2.					cytoplasm|nucleus					0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.27e-25)|Epithelial(43;1.02e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.14e-11)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000118)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|COAD - Colon adenocarcinoma(29;0.00939)|READ - Rectum adenocarcinoma(43;0.155)		ATCCCTGCAAGCAGTCGCCTG	0.592													14	73					0	0	0	0	A	186318369	A	A	186318369	2	1	195	1	0	0	0	0	0	0	0	1	667	962	34	4		4	ANKRD37	4	186318369	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	86461	186318369	4835907	110	35860											
FAT1	2195	broad.mit.edu	37	chr4	187628386	187628386	+	Frame_Shift_Del	DEL	C	-	-																															gctgtcaattgaaaatgtgtCtgtgtctgtaacaattgagt																										TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:187628386delC	uc003izf.2	-	2	2784	c.2596delG	c.(2596-2598)GACfs	p.D866fs	FAT1_uc010iso.1_Frame_Shift_Del_p.D866fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	866	Extracellular (Potential).|Cadherin 7.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GAAAATGTGTCTGTGTCTGTA	0.493										HNSCC(5;0.00058)			---	---	---								-	187628386	-	-	187628386	7	5	195	1	0	1	0	1	0	0	0	0	5721	913	32	0	11274	0	FAT1	4	187628386	Frame_Shift_Del	DEL	C	TCGA-CV-6936-01A-11D-1912-08	1310017	187628386	3525890	111	35861											
FAT1	2195	broad.mit.edu	37	chr4	187630110	187630110	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacctgccacgatgcttaaaGatgctatgtcaccattggca	11	10	8	12	1	1	1	1	0	0	1	1	2	1	1	3	1	3	3	3	1	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr4:187630110G>C	uc003izf.2	-	2	1060	c.872C>G	c.(871-873)TCT>TGT	p.S291C	FAT1_uc010iso.1_Missense_Mutation_p.S291C	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	291	Extracellular (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GATGCTTAAAGATGCTATGTC	0.488										HNSCC(5;0.00058)			20	173					0	0	0	0	C	187630110	C	C	187630110	3	2	195	1	0	0	0	0	1	0	0	0	5721	942	33	2	12998	2	FAT1	4	187630110	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1724	187630110	3524166	112	35862											
DNAH5	1767	broad.mit.edu	37	chr5	13901432	13901432	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccatcctgttgtaactgcGaattataggtttggcttctg	7	15	11	8	1	1	0	0	0	1	0	2	1	2	0	2	3	2	4	2	3	4	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:13901432G>A	uc003jfd.2	-	14	2023	c.1981C>T	c.(1981-1983)CGC>TGC	p.R661C		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	661	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTGTAACTGCGAATTATAGGT	0.532									Kartagener_syndrome				16	30					0	0	0	0	A	13901432	A	A	13901432	3	1	195	1	0	0	0	0	1	0	0	0	4626	1058	37	1	12157	1	DNAH5	5	13901432	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08		13901432	167013828	113	35863											
CDH9	1007	broad.mit.edu	37	chr5	26881405	26881405	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cattcccttcataggcatacGttgccagcgaatcatatgga	11	11	8	11	2	2	0	2	0	0	0	3	2	3	1	2	2	3	2	2	2	4	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:26881405G>A	uc003jgs.1	-	12	2379	c.2210C>T	c.(2209-2211)ACG>ATG	p.T737M	CDH9_uc011cnv.1_Missense_Mutation_p.T330M	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	737	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATAGGCATACGTTGCCAGCGA	0.423													29	72					0	0	0	0	A	26881405	A	A	26881405	3	1	195	1	0	0	0	0	1	0	0	0	3132	1145	40	1	163	1	CDH9	5	26881405	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	12979973	26881405	154033855	114	35864											
PRLR	5618	broad.mit.edu	37	chr5	35086419	35086419	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaacgacatttaaagatctCaggttttccaggaggtaact	14	11	9	7	1	1	2	1	0	1	2	3	4	2	3	1	3	2	2	1	3	4	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:35086419C>G	uc003jjm.2	-	4	624	c.94G>C	c.(94-96)GAG>CAG	p.E32Q	PRLR_uc003jjg.1_Missense_Mutation_p.E32Q|PRLR_uc003jjh.1_Missense_Mutation_p.E32Q|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Missense_Mutation_p.E32Q|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Intron|PRLR_uc010iuw.1_5'UTR	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	32	Fibronectin type-III 1.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTAAAGATCTCAGGTTTTCCA	0.448													16	55					0	0	0	0	G	35086419	G	G	35086419	3	3	195	1	0	0	0	0	1	0	0	0	12593	835	29	2	1802	2	PRLR	5	35086419	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	8205014	35086419	145828841	115	35865											
PAIP1	10605	broad.mit.edu	37	chr5	43539127	43539127	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgatctttaacttcatattCagtccgacatctaattaaag	13	16	4	8	1	4	1	2	1	2	0	5	2	5	1	1	0	1	0	1	0	5	8			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:43539127C>T	uc003job.2	-	5	992	c.745G>A	c.(745-747)GAA>AAA	p.E249K	PAIP1_uc003joa.2_Missense_Mutation_p.E170K|PAIP1_uc010ivp.2_Missense_Mutation_p.E170K|PAIP1_uc010ivo.2_Intron|PAIP1_uc003joc.2_Missense_Mutation_p.E137K	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	249	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ACTTCATATTCAGTCCGACAT	0.333													21	54					0	0	0	0	T	43539127	T	T	43539127	3	4	195	1	0	0	0	0	1	0	0	0	11450	835	29	2	722	2	PAIP1	5	43539127	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	8452708	43539127	137376133	116	35866											
SNX18	112574	broad.mit.edu	37	chr5	53814496	53814496	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctccaccttcgtcaagtcCggcggggaggccttcgtgct	4	11	12	14	4	2	0	1	0	1	0	6	1	3	1	4	4	1	1	4	4	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:53814496C>T	uc003jpj.3	+	1	904	c.714C>T	c.(712-714)TCC>TCT	p.S238S	SNX18_uc011cqg.1_Silent_p.S238S|SNX18_uc003jpi.3_Silent_p.S238S	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	238					cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				TCGTCAAGTCCGGCGGGGAGG	0.706													20	45					0	0	0	0	T	53814496	T	T	53814496	2	4	195	1	0	0	0	0	0	0	0	1	14953	639	23	1		1	SNX18	5	53814496	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	10275369	53814496	127100764	117	35867											
ANKRD34B	340120	broad.mit.edu	37	chr5	79854712	79854712	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggaggggtaaggccagctGagagctgggaatcagagctg	10	7	18	6	0	1	2	1	1	0	2	1	5	1	4	1	5	3	4	1	5	2	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:79854712G>C	uc010jam.2	-	4	1477	c.1127C>G	c.(1126-1128)TCA>TGA	p.S376*	ANKRD34B_uc003kgw.2_Nonsense_Mutation_p.S376*|ANKRD34B_uc010jan.2_Nonsense_Mutation_p.S376*	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	376						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		AAGGCCAGCTGAGAGCTGGGA	0.438													6	39					0	0	0	0	C	79854712	C	C	79854712	4	2	195	1	0	0	0	0	0	1	0	0	663	1294	45	2	421	2	ANKRD34B	5	79854712	Nonsense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	26040216	79854712	101060548	118	35868											
TTC37	9652	broad.mit.edu	37	chr5	94842673	94842673	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taatttcttattgcaacattGtaagtatcttggtcttctgc	9	19	6	7	0	4	0	0	0	4	0	4	0	4	0	0	1	3	3	0	1	5	9			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:94842673G>A	uc003klb.2	-	30	3327	c.3057C>T	c.(3055-3057)TAC>TAT	p.Y1019Y		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1019							binding			ovary(3)|pancreas(1)	4						TTGCAACATTGTAAGTATCTT	0.323													15	32					0	0	0	0	A	94842673	A	A	94842673	2	1	195	1	0	0	0	0	0	0	0	1	16773	1372	48	4		4	TTC37	5	94842673	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	14987961	94842673	86072587	119	35869											
LNPEP	4012	broad.mit.edu	37	chr5	96320825	96320825	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaacccctggcagcaagatCtgcttttccttgttttgatg	7	15	9	10	0	1	3	0	2	1	1	2	3	2	3	3	1	3	4	3	1	2	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:96320825C>G	uc003kmv.1	+	3	1416	c.902C>G	c.(901-903)TCT>TGT	p.S301C	LNPEP_uc003kmw.1_Missense_Mutation_p.S287C	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	301	Extracellular (Potential).			S -> L (in Ref. 6; AA sequence).	cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		GCAGCAAGATCTGCTTTTCCT	0.303													22	87					0	0	0	0	G	96320825	G	G	96320825	3	3	195	1	0	0	0	0	1	0	0	0	8906	913	32	2	912	2	LNPEP	5	96320825	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	1478152	96320825	84594435	120	35870											
NRG2	9542	broad.mit.edu	37	chr5	139231379	139231379	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggagtcagaagtcaggcTctcagaacgttccaggctcc	9	8	12	12	1	3	2	3	0	1	2	6	3	5	3	2	3	1	3	2	3	2	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:139231379T>A	uc003lex.1	-	9	1807	c.1582A>T	c.(1582-1584)AGC>TGC	p.S528C	NRG2_uc003lev.1_Missense_Mutation_p.S536C|NRG2_uc003lew.1_Missense_Mutation_p.S530C|NRG2_uc003ley.1_Missense_Mutation_p.S522C	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	528	Cytoplasmic (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGTCAGGCTCTCAGAACGT	0.632													7	32					0	0	0	0	A	139231379	A	A	139231379	3	1	195	1	0	0	0	0	1	0	0	0	10702	1551	54	5	978	5	NRG2	5	139231379	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	42910554	139231379	41683881	121	35871											
PCDHA5	56143	broad.mit.edu	37	chr5	140203557	140203557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccgaggccgtgtgcacaCggggcaagcccactctgttg	7	6	13	15	3	1	0	0	0	1	0	1	1	1	0	4	3	2	3	4	3	1	1	rs140039635		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:140203557C>T	uc003lhl.2	+	1	2197	c.2197C>T	c.(2197-2199)CGG>TGG	p.R733W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R733W|PCDHA5_uc003lhj.1_Missense_Mutation_p.R733W	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	733	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGTGCACACGGGGCAAGCC	0.662													15	33					0	0	0	0	T	140203557	T	T	140203557	3	4	195	1	0	0	0	0	1	0	0	0	11581	527	19	1	2199	1	PCDHA5	5	140203557	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	972178	140203557	40711703	122	35872											
PCDHB1	29930	broad.mit.edu	37	chr5	140433131	140433131	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatccactaaatatttggtCatttctctggtcatcctttc	8	17	4	12	0	3	0	2	0	1	0	7	0	5	0	3	2	0	0	3	2	3	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:140433131C>A	uc003lik.1	+	1	2153	c.2076C>A	c.(2074-2076)GTC>GTA	p.V692V		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	692	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATATTTGGTCATTTCTCTGG	0.388													22	82					1.96895e-08	3.65337e-08	1	0	A	140433131	A	A	140433131	2	1	195	1	0	0	0	0	0	0	0	1	11588	813	29	2		2	PCDHB1	5	140433131	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	229574	140433131	40482129	123	35873											
PCDHGA5	56110	broad.mit.edu	37	chr5	140746180	140746180	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacgaggtctccctcaccgcGgactcgaggaagagtcacct	9	6	11	15	4	3	1	2	0	1	1	5	5	3	3	3	3	0	0	3	3	1	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:140746180G>A	uc003lju.1	+	1	2283	c.2283G>A	c.(2281-2283)GCG>GCA	p.A761A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Silent_p.A761A	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	761	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTCACCGCGGACTCGAGGA	0.592													13	136					0	0	0	0	A	140746180	A	A	140746180	2	1	195	1	0	0	0	0	0	0	0	1	11611	1103	39	1		1	PCDHGA5	5	140746180	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	313049	140746180	40169080	124	35874											
PCDHGB6	56100	broad.mit.edu	37	chr5	140789449	140789449	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccgcaatgacaacgcaccGcgggtgctgtacccagctct	9	6	11	15	4	1	1	0	1	1	0	1	2	1	1	3	1	4	5	3	1	3	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:140789449G>A	uc003lkj.1	+	1	1680	c.1680G>A	c.(1678-1680)CCG>CCA	p.P560P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.P560P	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	560	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACGCACCGCGGGTGCTGT	0.662													6	22					0	0	0	0	A	140789449	A	A	140789449	2	1	195	1	0	0	0	0	0	0	0	1	11621	1074	38	1		1	PCDHGB6	5	140789449	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	43269	140789449	40125811	125	35875											
SPARC	6678	broad.mit.edu	37	chr5	151052775	151052775	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaggattagctcccacagaTacctggaattgagggagaag	14	7	12	8	0	0	3	0	1	0	2	1	6	1	5	2	3	2	1	2	3	4	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:151052775T>C	uc003luh.2	-	3	147	c.123A>G	c.(121-123)GTA>GTG	p.V41V	GM2A_uc011dcs.1_Intron|SPARC_uc003lug.2_5'UTR|SPARC_uc003lui.2_Silent_p.V41V	NM_003118	NP_003109	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich	41	Asp/Glu-rich (acidic; binds calcium).				ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(1)	1		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	CTCCCACAGATACCTGGAATT	0.522													34	67					0	0	0	0	C	151052775	C	C	151052775	2	2	195	1	0	0	0	0	0	0	0	1	15061	1393	49	5		5	SPARC	5	151052775	Silent	SNP	T	TCGA-CV-6936-01A-11D-1912-08	10263326	151052775	29862485	126	35876											
HK3	3101	broad.mit.edu	37	chr5	176308467	176308467	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctctagcaccatcagggcGtcatctgaggtcaggggtag	9	8	13	11	1	5	1	3	1	2	0	5	1	5	1	2	4	1	2	2	4	2	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:176308467G>A	uc003mfa.2	-	18	2555	c.2463C>T	c.(2461-2463)GAC>GAT	p.D821D	HK3_uc003mez.2_Silent_p.D377D	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	821	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCATCAGGGCGTCATCTGAGG	0.652													9	17					0	0	0	0	A	176308467	A	A	176308467	2	1	195	1	0	0	0	0	0	0	0	1	7231	1136	40	1		1	HK3	5	176308467	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	25255692	176308467	4606793	127	35877											
FLT4	2324	broad.mit.edu	37	chr5	180057046	180057046	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcagtggcgtggacacgagCatgccccgccggtcatccca	8	5	13	15	4	1	0	1	0	0	0	2	2	2	1	4	3	3	2	4	3	0	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr5:180057046C>A	uc003mma.3	-	5	652	c.573G>T	c.(571-573)ATG>ATT	p.M191I	FLT4_uc003mlz.3_Missense_Mutation_p.M191I|FLT4_uc003mmb.1_5'Flank|FLT4_uc011dgy.1_Missense_Mutation_p.M191I|FLT4_uc011dgz.1_Missense_Mutation_p.M191I|FLT4_uc011dha.1_Missense_Mutation_p.C175F	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	191	Ig-like C2-type 2.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGACACGAGCATGCCCCGCC	0.637									Congenital_Hereditary_Lymphedema				7	29					1.58986e-06	2.93303e-06	1	0	A	180057046	A	A	180057046	3	1	195	1	0	0	0	0	1	0	0	0	5976	710	25	4	3630	4	FLT4	5	180057046	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	3748579	180057046	858214	128	35878											
SSR1	6745	broad.mit.edu	37	chr6	7301699	7301699	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctggatataaaactggtaGtcctgaggataacggaatga	14	11	11	5	1	1	2	0	2	1	0	2	5	2	5	1	4	2	1	1	4	6	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:7301699G>T	uc003mxf.3	-	4	575	c.387C>A	c.(385-387)GAC>GAA	p.D129E	SSR1_uc003mxg.3_Intron|SSR1_uc010jny.2_Missense_Mutation_p.D129E	NM_003144	NP_003135	P43307	SSRA_HUMAN	signal sequence receptor, alpha precursor	129	Lumenal (Potential).				cotranslational protein targeting to membrane|positive regulation of cell proliferation	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Ovarian(93;0.0398)					AAAACTGGTAGTCCTGAGGAT	0.428													23	57					3.7963e-18	7.34105e-18	1	0	T	7301699	T	T	7301699	3	4	195	1	0	0	0	0	1	0	0	0	15256	1020	36	4	493	4	SSR1	6	7301699	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08		7301699	163813368	129	35879											
OR10C1	442194	broad.mit.edu	37	chr6	29407891	29407891	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctctgtctttctcactatCtacctgctgaccgtggcagg	5	15	8	13	1	4	1	1	1	4	0	6	1	4	1	2	2	2	2	2	2	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:29407891C>T	uc011dlp.1	+	1	99	c.99C>T	c.(97-99)ATC>ATT	p.I33I	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCTCACTATCTACCTGCTGA	0.557													31	59					0	0	0	0	T	29407891	T	T	29407891	2	4	195	1	0	0	0	0	0	0	0	1	10952	903	32	2		2	OR10C1	6	29407891	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	22106192	29407891	141707176	130	35880											
NRM	11270	broad.mit.edu	37	chr6	30658649	30658649	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agactccgggatccctccaaGaagtggccgaagggaggtaa	12	5	14	10	2	0	2	0	0	0	2	3	5	3	4	4	4	0	1	4	4	4	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:30658649G>C	uc003nrc.2	-	1	121	c.103C>G	c.(103-105)CTT>GTT	p.L35V	KIAA1949_uc003nrb.3_5'Flank|NRM_uc003nrd.2_RNA|NRM_uc003nre.2_5'UTR	NM_007243	NP_009174	Q8IXM6	NRM_HUMAN	nurim	35	Perinuclear space (Potential).					integral to membrane|nuclear inner membrane					0						ATCCCTCCAAGAAGTGGCCGA	0.642													21	47					0	0	0	0	C	30658649	C	C	30658649	3	2	195	1	0	0	0	0	1	0	0	0	10711	942	33	2	701	2	NRM	6	30658649	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1250758	30658649	140456418	131	35881											
CYP21A2	1589	broad.mit.edu	37	chr6	32007955	32007955	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaacaccctctcctgggcCgtggtttttttgcttcacca	6	13	8	14	1	2	0	1	0	1	0	3	0	2	0	4	2	2	3	4	2	1	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:32007955C>T	uc003nze.1	+	7	1030	c.912C>T	c.(910-912)GCC>GCT	p.A304A	CYP21A2_uc003nzf.1_Silent_p.A274A	NM_000500	NP_000491	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A,	303					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						TCTCCTGGGCCGTGGTTTTTT	0.617													30	111					0	0	0	0	T	32007955	T	T	32007955	2	4	195	1	0	0	0	0	0	0	0	1	4170	639	23	1		1	CYP21A2	6	32007955	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	1349306	32007955	139107112	132	35882											
FKBPL	63943	broad.mit.edu	37	chr6	32097359	32097359	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagttcagcaaccagtttttCagctccttgagtatgctcta	10	14	7	10	0	3	1	2	1	1	0	4	1	4	1	2	0	4	6	2	0	4	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:32097359C>T	uc003nzr.2	-	2	469	c.199G>A	c.(199-201)GAA>AAA	p.E67K	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	67					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						ACCAGTTTTTCAGCTCCTTGA	0.512													11	66					0	0	0	0	T	32097359	T	T	32097359	3	4	195	1	0	0	0	0	1	0	0	0	5948	835	29	2	854	2	FKBPL	6	32097359	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	89404	32097359	139017708	133	35883											
DNAH8	1769	broad.mit.edu	37	chr6	38821072	38821072	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatccgctttctatcaaatCagtgattcaggatttcaact	12	14	6	9	1	5	2	4	1	1	1	6	3	6	3	1	1	1	1	1	1	3	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:38821072C>G	uc003ooe.1	+	39	5631	c.5031C>G	c.(5029-5031)ATC>ATG	p.I1677M		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TCTATCAAATCAGTGATTCAG	0.368													19	32					0	0	0	0	G	38821072	G	G	38821072	3	3	195	1	0	0	0	0	1	0	0	0	4629	816	29	2	5177	2	DNAH8	6	38821072	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	6723713	38821072	132293995	134	35884											
BYSL	705	broad.mit.edu	37	chr6	41900357	41900357	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaactgctccggctgcagccCcatccacagctatcgcccga	8	6	9	18	3	0	0	0	0	0	0	3	2	2	0	5	1	5	4	5	1	2	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:41900357C>T	uc003orl.2	+	7	1563	c.1227C>T	c.(1225-1227)CCC>CCT	p.P409P		NM_004053	NP_004044	Q13895	BYST_HUMAN	bystin	409					cell adhesion|female pregnancy|ribosome biogenesis	cytoplasm|nucleolus					0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000473)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGCTGCAGCCCCATCCACAGC	0.587													12	64					0	0	0	0	T	41900357	T	T	41900357	2	4	195	1	0	0	0	0	0	0	0	1	1581	610	22	4		4	BYSL	6	41900357	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	3079285	41900357	129214710	135	35885											
SENP6	26054	broad.mit.edu	37	chr6	76344432	76344433	+	Nonsense_Mutation	DNP	GC	TT	TT																															tgaatctgcagtgaaaatacGcaaaatacgtcattatgttc																										TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:76344432_76344433GC>TT	uc003pid.3	+	5	982_983	c.363_364GC>TT	c.(361-366)ACGCAA>ACTTAA	p.Q122*	SENP6_uc003pie.3_Nonsense_Mutation_p.Q122*|SENP6_uc003pic.2_Nonsense_Mutation_p.Q122*|SENP6_uc003pif.1_Nonsense_Mutation_p.Q13*	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	122					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				GTGAAAATACGCAAAATACGTC	0.322													8	17					0	0	0	0	TT	76344433	TT	TT	76344432	4	4	195	1	0	0	0	0	0	1	0	0	14115	1074	38	3	381	3	SENP6	6	76344432	Nonsense_Mutation	DNP	GC	TCGA-CV-6936-01A-11D-1912-08	34444075	76344432	94770635	136	35886											
PREP	5550	broad.mit.edu	37	chr6	105816838	105816838	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacacaaaatatcttctgaCtgatcggttcccaagacatg	13	10	7	11	1	2	3	0	2	2	1	4	3	3	3	1	1	0	2	1	1	4	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:105816838C>A	uc003prc.2	-	6	860	c.657G>T	c.(655-657)CAG>CAT	p.Q219H		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	219					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	TATCTTCTGACTGATCGGTTC	0.418													23	33					5.35356e-11	1.00204e-10	1	0	A	105816838	A	A	105816838	3	1	195	1	0	0	0	0	1	0	0	0	12536	564	20	4	1515	4	PREP	6	105816838	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	29472406	105816838	65298229	137	35887											
FRK	2444	broad.mit.edu	37	chr6	116265528	116265528	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actccagataggccattccaGaggcaacctgtgccgccatg	10	7	10	14	1	0	2	0	0	0	2	2	2	2	2	6	2	2	1	6	2	2	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:116265528G>A	uc003pwi.1	-	6	1466	c.1019C>T	c.(1018-1020)TCT>TTT	p.S340F		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	340	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		GGCCATTCCAGAGGCAACCTG	0.418													10	40					0	0	0	0	A	116265528	A	A	116265528	3	1	195	1	0	0	0	0	1	0	0	0	6082	942	33	2	510	2	FRK	6	116265528	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	10448690	116265528	54849539	138	35888											
GRM1	2911	broad.mit.edu	37	chr6	146720758	146720758	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtccgcatgcatgttggCgatggcaagctgccctgccg	5	10	14	12	3	0	0	0	0	0	0	1	1	1	0	3	2	4	6	3	2	1	2	rs148042148		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:146720758C>T	uc010khw.1	+	8	3053	c.2583C>T	c.(2581-2583)GGC>GGT	p.G861G	GRM1_uc010khv.1_Silent_p.G861G|GRM1_uc003qll.2_Silent_p.G861G|GRM1_uc011edz.1_Silent_p.G861G|GRM1_uc011eea.1_Silent_p.G861G	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	861	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TGCATGTTGGCGATGGCAAGC	0.517													12	25					0	0	0	0	T	146720758	T	T	146720758	2	4	195	1	0	0	0	0	0	0	0	1	6835	755	27	1		1	GRM1	6	146720758	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	30455230	146720758	24394309	139	35889											
TAB2	23118	broad.mit.edu	37	chr6	149699950	149699950	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaccaccaaccattcattCatctggtagctcacagtctt	12	11	4	14	0	5	0	3	0	2	0	5	0	5	0	3	1	3	2	3	1	3	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:149699950C>T	uc003qmj.2	+	3	1077	c.899C>T	c.(898-900)TCA>TTA	p.S300L	TAB2_uc011eec.1_Missense_Mutation_p.S268L|TAB2_uc010kia.1_Missense_Mutation_p.S300L|TAB2_uc010kib.1_Missense_Mutation_p.S300L|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	300					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						ACCATTCATTCATCTGGTAGC	0.433													9	82					0	0	0	0	T	149699950	T	T	149699950	3	4	195	1	0	0	0	0	1	0	0	0	15562	838	29	2	905	2	TAB2	6	149699950	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	2979192	149699950	21415117	140	35890											
SYNE1	23345	broad.mit.edu	37	chr6	152737810	152737810	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catccagactgacggcagcaGattctaatgctttagcattt	11	12	8	10	1	1	3	0	1	1	2	2	3	2	3	1	1	3	4	1	1	2	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:152737810G>A	uc010kiw.2	-	41	6364	c.5762C>T	c.(5761-5763)TCT>TTT	p.S1921F	SYNE1_uc003qot.3_Missense_Mutation_p.S1928F|SYNE1_uc003qou.3_Missense_Mutation_p.S1921F|SYNE1_uc010kjb.1_Missense_Mutation_p.S1904F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1921	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACGGCAGCAGATTCTAATGC	0.453										HNSCC(10;0.0054)			21	46					0	0	0	0	A	152737810	A	A	152737810	3	1	195	1	0	0	0	0	1	0	0	0	15511	942	33	2	21128	2	SYNE1	6	152737810	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	3037860	152737810	18377257	141	35891											
PDE10A	10846	broad.mit.edu	37	chr6	165792780	165792780	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaggtctgtggcaatgaTggctttgcggatgatctcaa	10	11	13	7	1	2	2	1	2	2	0	3	3	2	3	0	4	2	3	0	4	3	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr6:165792780T>A	uc003qun.2	-	19	2099	c.1858A>T	c.(1858-1860)ATC>TTC	p.I620F	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.I550F|PDE10A_uc003quo.2_Missense_Mutation_p.I630F	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	620					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GTGGCAATGATGGCTTTGCGG	0.413													7	41					0	0	0	0	A	165792780	A	A	165792780	3	1	195	1	0	0	0	0	1	0	0	0	11684	1464	51	5	501	5	PDE10A	6	165792780	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	13054970	165792780	5322287	142	35892											
SFRP4	6424	broad.mit.edu	37	chr7	37956080	37956080	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgcctcgcagggcgcgccGcgcacgcccagcgccaggtg	5	2	15	19	8	0	0	0	0	0	0	1	0	0	0	5	2	1	2	5	2	0	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:37956080G>A	uc003tfo.3	-	1	446	c.60C>T	c.(58-60)CGC>CGT	p.R20R		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	20	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						AGGGCGCGCCGCGCACGCCCA	0.682													19	32					0	0	0	0	A	37956080	A	A	37956080	2	1	195	1	0	0	0	0	0	0	0	1	14228	1074	38	1		1	SFRP4	7	37956080	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08		37956080	121182583	143	35893											
ABCA13	154664	broad.mit.edu	37	chr7	48318187	48318187	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttataaataattcattccctCtaagaaacagagcaacatta	18	12	3	8	0	2	2	1	0	1	2	3	2	3	2	1	0	3	1	1	0	8	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:48318187C>G	uc003toq.2	+	18	7421	c.7396C>G	c.(7396-7398)CTA>GTA	p.L2466V	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2466					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTCATTCCCTCTAAGAAACAG	0.358													12	129					0	0	0	0	G	48318187	G	G	48318187	3	3	195	1	0	0	0	0	1	0	0	0	31	912	32	2	7295	2	ABCA13	7	48318187	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	10362107	48318187	110820476	144	35894											
WBSCR17	64409	broad.mit.edu	37	chr7	70853278	70853278	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atatccatcatattcatcttCgtgaacgaggccctgtcggt	9	13	8	11	3	3	1	2	1	1	0	6	2	4	1	2	2	1	0	2	2	3	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:70853278C>G	uc003tvy.2	+	3	480	c.480C>G	c.(478-480)TTC>TTG	p.F160L	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	160	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TATTCATCTTCGTGAACGAGG	0.527													6	67					0	0	0	0	G	70853278	G	G	70853278	3	3	195	1	0	0	0	0	1	0	0	0	17332	883	31	3	490	3	WBSCR17	7	70853278	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	22535091	70853278	88285385	145	35895											
PCLO	27445	broad.mit.edu	37	chr7	82475906	82475906	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttggtggctcatgaagtTccagatgctgggaattttca	8	15	11	7	0	2	2	2	1	0	1	3	3	3	3	1	3	1	3	1	3	2	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:82475906T>A	uc003uhx.2	-	12	14097	c.13808A>T	c.(13807-13809)GAA>GTA	p.E4603V	PCLO_uc003uhv.2_Missense_Mutation_p.E4603V|PCLO_uc003uht.1_Missense_Mutation_p.E54V|PCLO_uc003uhu.1_Missense_Mutation_p.E33V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4491					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTCATGAAGTTCCAGATGCTG	0.338													19	17					0	0	0	0	A	82475906	A	A	82475906	3	1	195	1	0	0	0	0	1	0	0	0	11637	1783	62	5	1693	5	PCLO	7	82475906	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	11622628	82475906	76662757	146	35896											
RUNDC3B	154661	broad.mit.edu	37	chr7	87258202	87258202	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtggcggcggaggcggcaaGaaaagcctgagcgcccgcaa	10	2	18	11	5	0	2	0	1	0	1	0	3	0	3	2	6	2	2	2	6	4	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:87258202G>C	uc003ujb.2	+	1	474	c.63G>C	c.(61-63)AAG>AAC	p.K21N	ABCB1_uc003uiz.1_Intron|ABCB1_uc003uja.1_Intron|ABCB1_uc010lei.1_Intron|RUNDC3B_uc011khd.1_Missense_Mutation_p.K21N|RUNDC3B_uc011khe.1_Missense_Mutation_p.K21N|RUNDC3B_uc003ujc.2_Missense_Mutation_p.K21N	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	21										skin(1)	1	Esophageal squamous(14;0.00164)					GAGGCGGCAAGAAAAGCCTGA	0.716													4	11					0	0	0	0	C	87258202	C	C	87258202	3	2	195	1	0	0	0	0	1	0	0	0	13810	933	33	2	65	2	RUNDC3B	7	87258202	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	4782296	87258202	71880461	147	35897											
CYP3A7	1551	broad.mit.edu	37	chr7	99306662	99306662	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaggggcctcctacctttCagggaggaacttctcaggct	7	9	11	14	0	2	0	2	0	1	0	4	2	3	2	4	5	2	1	4	5	2	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:99306662C>T	uc003uru.2	-	11	1354	c.1249G>A	c.(1249-1251)GAA>AAA	p.E417K	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	417					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TCCTACCTTTCAGGGAGGAAC	0.512													18	89					0	0	0	0	T	99306662	T	T	99306662	3	4	195	1	0	0	0	0	1	0	0	0	4198	835	29	2	274	2	CYP3A7	7	99306662	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	12048460	99306662	59832001	148	35898											
MUC17	140453	broad.mit.edu	37	chr7	100676630	100676630	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacactggtggccagttctGaggctagcaccctttcaaca	9	9	9	14	0	2	1	1	1	1	0	2	1	2	1	3	3	2	3	3	3	2	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:100676630G>C	uc003uxp.1	+	3	1986	c.1933G>C	c.(1933-1935)GAG>CAG	p.E645Q	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	645	Extracellular (Potential).|8.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGCCAGTTCTGAGGCTAGCAC	0.483													115	469					0	0	0	0	C	100676630	C	C	100676630	3	2	195	1	0	0	0	0	1	0	0	0	10027	1291	45	2	1943	2	MUC17	7	100676630	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1369968	100676630	58462033	149	35899											
C7orf66	154907	broad.mit.edu	37	chr7	108524578	108524578	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaccatcactgggtgtcatCacagccatcattttgcaagg	11	10	9	11	0	4	1	4	0	0	1	4	1	4	1	2	2	2	1	2	2	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:108524578C>G	uc003vfo.2	-	1	60	c.12G>C	c.(10-12)GTG>GTC	p.V4V		NM_001024607	NP_001019778	A4D0T2	CG066_HUMAN	hypothetical protein LOC154907	4						integral to membrane				ovary(2)	2						TGGGTGTCATCACAGCCATCA	0.413													3	54					0	0	0	0	G	108524578	G	G	108524578	2	3	195	1	0	0	0	0	0	0	0	1	2423	813	29	2		2	C7orf66	7	108524578	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	7847948	108524578	50614085	150	35900											
C7orf58	79974	broad.mit.edu	37	chr7	120764400	120764400	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagctgcaaacattttttGagacattcctgagagccagt	12	11	8	10	0	0	2	0	2	0	2	1	4	1	2	2	0	4	2	2	0	1	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:120764400G>C	uc003vjq.3	+	8	1381	c.934G>C	c.(934-936)GAG>CAG	p.E312Q	C7orf58_uc003vjr.1_Missense_Mutation_p.E312Q|C7orf58_uc003vjs.3_Missense_Mutation_p.E312Q|C7orf58_uc003vjt.3_Missense_Mutation_p.E92Q|C7orf58_uc010lkk.1_Missense_Mutation_p.E92Q	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	312						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AACATTTTTTGAGACATTCCT	0.393													16	53					0	0	0	0	C	120764400	C	C	120764400	3	2	195	1	0	0	0	0	1	0	0	0	2416	1291	45	2	960	2	C7orf58	7	120764400	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	12239822	120764400	38374263	151	35901											
FSCN3	29999	broad.mit.edu	37	chr7	127240328	127240328	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgccctcaacttctgtatcGagcttcaggggagcaactta	9	12	9	11	1	3	0	2	0	1	0	4	2	3	1	1	2	5	3	1	2	4	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:127240328G>A	uc003vmd.1	+	6	1591	c.1372G>A	c.(1372-1374)GAG>AAG	p.E458K	FSCN3_uc011koh.1_Missense_Mutation_p.R322Q|FSCN3_uc010llc.1_Missense_Mutation_p.R456Q	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	458						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						CTTCTGTATCGAGCTTCAGGG	0.537													6	59					0	0	0	0	A	127240328	A	A	127240328	3	1	195	1	0	0	0	0	1	0	0	0	6103	1059	37	1	1394	1	FSCN3	7	127240328	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	6475928	127240328	31898335	152	35902											
LRGUK	136332	broad.mit.edu	37	chr7	133812362	133812362	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggacggagatgaggaccaggGcgagggcgaggcgggatccg	9	2	22	8	5	0	2	0	1	0	1	1	8	1	5	2	7	0	0	2	7	0	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:133812362G>A	uc003vrm.1	+	1	258	c.242G>A	c.(241-243)GGC>GAC	p.G81D		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	81							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						GAGGACCAGGGCGAGGGCGAG	0.612													7	40					0	0	0	0	A	133812362	A	A	133812362	3	1	195	1	0	0	0	0	1	0	0	0	8993	1203	42	4	244	4	LRGUK	7	133812362	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	6572034	133812362	25326301	153	35903											
KIAA1549	57670	broad.mit.edu	37	chr7	138603487	138603487	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaacggtatagtaatgccGtcgcctaacggctgtggcat	9	9	13	10	4	0	0	0	0	0	0	1	0	0	0	2	4	3	5	2	4	5	4	rs79934303	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:138603487G>A	uc011kql.1	-	2	934	c.885C>T	c.(883-885)GAC>GAT	p.D295D	KIAA1549_uc003vuk.3_Silent_p.D245D|KIAA1549_uc011kqj.1_Silent_p.D295D	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	295						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TAGTAATGCCGTCGCCTAACG	0.537			O	BRAF	pilocytic astrocytoma								16	54					0	0	0	0	A	138603487	A	A	138603487	2	1	195	1	0	0	0	0	0	0	0	1	8283	1136	40	1		1	KIAA1549	7	138603487	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	4791125	138603487	20535176	154	35904											
PARP12	64761	broad.mit.edu	37	chr7	139727113	139727113	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagggccaggttctgtactcGctcaatcttctgaacaaagt	10	11	10	10	1	4	1	1	1	3	0	5	2	4	1	1	2	2	3	1	2	4	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:139727113G>A	uc003vvl.1	-	10	2465	c.1591C>T	c.(1591-1593)CGA>TGA	p.R531*	PARP12_uc003vvk.1_Nonsense_Mutation_p.R317*|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	531	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					TTCTGTACTCGCTCAATCTTC	0.537													5	42					0	0	0	0	A	139727113	A	A	139727113	4	1	195	1	0	0	0	0	0	1	0	0	11511	1095	38	1	526	1	PARP12	7	139727113	Nonsense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1123626	139727113	19411550	155	35905											
ADCK2	90956	broad.mit.edu	37	chr7	140373236	140373236	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccctccgagtgccctcgcGatgccaggctctgctggctt	3	9	13	16	3	1	0	0	0	1	0	3	2	2	0	4	3	3	3	4	3	0	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:140373236G>T	uc003vvy.1	+	1	284	c.106G>T	c.(106-108)GAT>TAT	p.D36Y	ADCK2_uc003vvz.2_Missense_Mutation_p.D36Y	NM_052853	NP_443085	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	36						integral to membrane	ATP binding|protein serine/threonine kinase activity				0	Melanoma(164;0.00956)					GTGCCCTCGCGATGCCAGGCT	0.677													6	12					0.00116845	0.00210714	1	0	T	140373236	T	T	140373236	3	4	195	1	0	0	0	0	1	0	0	0	289	1058	37	3	108	3	ADCK2	7	140373236	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	646123	140373236	18765427	156	35906											
KEL	3792	broad.mit.edu	37	chr7	142643301	142643301	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctctcacatacagcacttCgggtgctcgggccaaaggcc	9	7	11	14	2	1	0	1	0	1	0	4	0	1	0	2	3	4	3	2	3	2	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr7:142643301C>T	uc003wcb.2	-	11	1517	c.1307G>A	c.(1306-1308)CGA>CAA	p.R436Q		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	436	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					TACAGCACTTCGGGTGCTCGG	0.577													8	11					0	0	0	0	T	142643301	T	T	142643301	3	4	195	1	0	0	0	0	1	0	0	0	8181	884	31	1	927	1	KEL	7	142643301	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	2270065	142643301	16495362	157	35907											
CSMD1	64478	broad.mit.edu	37	chr8	3267046	3267046	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgggcattcaaaggtgagtGtatctccatggaggaaactg	11	9	13	8	1	2	1	1	1	1	0	3	3	2	3	2	4	1	2	2	4	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:3267046G>T	uc011kwk.1	-	13	2036	c.1646C>A	c.(1645-1647)ACA>AAA	p.T549K	CSMD1_uc011kwj.1_5'UTR	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	549	Extracellular (Potential).|Sushi 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAAGGTGAGTGTATCTCCATG	0.527													4	5					0.000602214	0.00108908	1	0	T	3267046	T	T	3267046	3	4	195	1	0	0	0	0	1	0	0	0	3961	1377	48	4		4	CSMD1	8	3267046	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08		3267046	143096976	158	35908											
DEFA4	1669	broad.mit.edu	37	chr8	6794410	6794410	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agaatagcagcgaggagggcGataatcctcatggctggggt	11	7	16	7	2	1	1	1	0	0	1	2	4	2	2	1	5	2	2	1	5	3	2	rs61749084	byFrequency	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:6794410G>C	uc003wqu.1	-	2	63	c.12C>G	c.(10-12)ATC>ATG	p.I4M		NM_001925	NP_001916	P12838	DEF4_HUMAN	defensin, alpha 4 preproprotein	4					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				large_intestine(1)	1				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		CGAGGAGGGCGATAATCCTCA	0.622													4	9					0	0	0	0	C	6794410	C	C	6794410	3	2	195	1	0	0	0	0	1	0	0	0	4408	1048	37	3	289	3	DEFA4	8	6794410	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	3527364	6794410	139569612	159	35909											
KIF13B	23303	broad.mit.edu	37	chr8	28974435	28974435	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctggaccgtcacgcgcacGatcaggaacaaccgctcgtc	10	5	11	15	6	2	0	2	0	0	0	4	3	2	2	2	2	3	3	2	2	2	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:28974435G>A	uc003xhh.3	-	31	3809	c.3750C>T	c.(3748-3750)ATC>ATT	p.I1250I	uc003xhi.1_Intron	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1250					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		TCACGCGCACGATCAGGAACA	0.602													26	63					0	0	0	0	A	28974435	A	A	28974435	2	1	195	1	0	0	0	0	0	0	0	1	8314	1048	37	1		1	KIF13B	8	28974435	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	22180025	28974435	117389587	160	35910											
IKBKB	3551	broad.mit.edu	37	chr8	42179657	42179657	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaagaaagtgcgagtgatCtatacgcagctcaggtatga	14	8	13	6	2	2	4	1	2	1	2	2	6	2	4	0	1	3	3	0	1	5	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:42179657C>G	uc003xow.1	+	18	2001	c.1824C>G	c.(1822-1824)ATC>ATG	p.I608M	IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.I385M|IKBKB_uc003xox.1_Missense_Mutation_p.I329M|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.I606M|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.I549M	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	608					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	TGCGAGTGATCTATACGCAGC	0.557													8	63					0	0	0	0	G	42179657	G	G	42179657	3	3	195	1	0	0	0	0	1	0	0	0	7650	903	32	2	1890	2	IKBKB	8	42179657	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	13205222	42179657	104184365	161	35911											
MOS	4342	broad.mit.edu	37	chr8	57025647	57025648	+	Missense_Mutation	DNP	GG	AA	AA																															ctcgaagacggcagcggagaGggacgggcgcaggtcgtagg																										TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:57025647_57025648GG>AA	uc011leb.1	-	1	894_895	c.894_895CC>TT	c.(892-897)TCCCTC>TCTTTC	p.L299F		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	299	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			GCAGCGGAGAGGGACGGGCGCA	0.683													9	31					0	0	0	0	AA	57025648	AA	AA	57025647	3	1	195	1	0	0	0	0	1	0	0	0	9765	1000	35	4	148	4	MOS	8	57025647	Missense_Mutation	DNP	GG	TCGA-CV-6936-01A-11D-1912-08	14845990	57025647	89338375	162	35912											
MYBL1	4603	broad.mit.edu	37	chr8	67514655	67514655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accttgtcagataattacctCgtcccttgtccattttactc	8	16	4	13	1	1	1	1	0	0	1	5	1	3	1	4	0	2	0	4	0	3	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:67514655C>T	uc003xwj.2	-	2	531	c.124G>A	c.(124-126)GAG>AAG	p.E42K	MYBL1_uc003xwl.2_Missense_Mutation_p.E42K|MYBL1_uc003xwk.2_Missense_Mutation_p.E42K	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	42	HTH myb-type 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			ATAATTACCTCGTCCCTTGTC	0.308													16	45					0	0	0	0	T	67514655	T	T	67514655	3	4	195	1	0	0	0	0	1	0	0	0	10062	893	31	1	2194	1	MYBL1	8	67514655	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	10489008	67514655	78849367	163	35913											
CSPP1	79848	broad.mit.edu	37	chr8	68007843	68007843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcacagatttaatgaggatCgtgtttttgatagacggtat	11	16	10	4	2	1	4	1	2	0	2	2	5	1	5	0	2	0	2	0	2	3	7	rs114953032	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:68007843C>T	uc003xxi.2	+	8	962	c.931C>T	c.(931-933)CGT>TGT	p.R311C	CSPP1_uc003xxg.1_Missense_Mutation_p.R303C|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.R276C|CSPP1_uc003xxk.2_5'UTR	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	311						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TAATGAGGATCGTGTTTTTGA	0.373													6	34					0	0	0	0	T	68007843	T	T	68007843	3	4	195	1	0	0	0	0	1	0	0	0	3979	884	31	1	961	1	CSPP1	8	68007843	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	493188	68007843	78356179	164	35914											
PRDM14	63978	broad.mit.edu	37	chr8	70964454	70964454	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggcagcatgggatgcaaaaGatttaccacagtacttgcat	13	9	11	8	0	0	1	0	0	0	1	0	2	0	2	1	2	5	5	1	2	4	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:70964454G>C	uc003xym.2	-	8	1776	c.1574C>G	c.(1573-1575)TCT>TGT	p.S525C		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	525	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GGATGCAAAAGATTTACCACA	0.517													19	121					0	0	0	0	C	70964454	C	C	70964454	3	2	195	1	0	0	0	0	1	0	0	0	12517	942	33	2	145	2	PRDM14	8	70964454	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	2956611	70964454	75399568	165	35915											
ZFHX4	79776	broad.mit.edu	37	chr8	77775694	77775694	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttgcaggcattacagaaTgcaattgctggtgacccagc	11	9	11	10	0	0	2	0	1	0	1	0	2	0	2	1	2	5	5	1	2	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:77775694T>C	uc003yav.2	+	11	9996	c.9609T>C	c.(9607-9609)AAT>AAC	p.N3203N		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3199						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CATTACAGAATGCAATTGCTG	0.443										HNSCC(33;0.089)			39	134					0	0	0	0	C	77775694	C	C	77775694	2	2	195	1	0	0	0	0	0	0	0	1	17702	1461	51	5		5	ZFHX4	8	77775694	Silent	SNP	T	TCGA-CV-6936-01A-11D-1912-08	6811240	77775694	68588328	166	35916											
CNGB3	54714	broad.mit.edu	37	chr8	87645041	87645041	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aattcaagagttgaaaaacaAtttcaaataaagtttgtggt	18	13	7	3	0	2	2	2	1	0	1	2	2	2	2	0	1	1	2	0	1	8	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:87645041A>G	uc003ydx.2	-	11	1305	c.1259T>C	c.(1258-1260)ATT>ACT	p.I420T	CNGB3_uc010maj.2_Missense_Mutation_p.I282T	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	420	Helical; Name=H5; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TTGAAAAACAATTTCAAATAA	0.353													14	19					0	0	0	0	G	87645041	G	G	87645041	3	3	195	1	0	0	0	0	1	0	0	0	3616	101	4	5	1202	5	CNGB3	8	87645041	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	9869347	87645041	58718981	167	35917											
CNGB3	54714	broad.mit.edu	37	chr8	87738776	87738776	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacctgtttggaccttctttCccggggtccatttccttctg	3	16	8	14	1	2	0	0	0	2	0	5	1	5	1	5	3	0	1	5	3	0	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:87738776C>T	uc003ydx.2	-	3	367	c.321G>A	c.(319-321)GGG>GGA	p.G107G		NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	107	Cytoplasmic (Potential).		G -> R (in ACHM3; uncertain pathogenicity).		signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						GACCTTCTTTCCCGGGGTCCA	0.453													64	241					0	0	0	0	T	87738776	T	T	87738776	2	4	195	1	0	0	0	0	0	0	0	1	3616	842	30	2		2	CNGB3	8	87738776	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	93735	87738776	58625246	168	35918											
OSGIN2	734	broad.mit.edu	37	chr8	90937360	90937360	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtagactcaaatcttttatCtgattataccagctttcccg	10	16	5	10	1	3	2	1	1	2	1	4	2	4	2	2	0	2	2	2	0	5	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:90937360C>T	uc003yeg.2	+	6	1464	c.1118C>T	c.(1117-1119)TCT>TTT	p.S373F	OSGIN2_uc003yeh.2_Missense_Mutation_p.S417F	NM_004337	NP_004328	Q9Y236	OSGI2_HUMAN	oxidative stress induced growth inhibitor family	373					germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AATCTTTTATCTGATTATACC	0.358													14	152					0	0	0	0	T	90937360	T	T	90937360	3	4	195	1	0	0	0	0	1	0	0	0	11344	913	32	2	1272	2	OSGIN2	8	90937360	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	3198584	90937360	55426662	169	35919											
CSMD3	114788	broad.mit.edu	37	chr8	113364752	113364752	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgtggttcaggacaggaatCcaaaccaattgctaagaata	15	10	9	7	0	1	1	1	0	0	1	2	3	2	3	2	3	2	2	2	3	6	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:113364752C>A	uc003ynu.2	-	39	6307	c.6148G>T	c.(6148-6150)GAT>TAT	p.D2050Y	CSMD3_uc003yns.2_Missense_Mutation_p.D1252Y|CSMD3_uc003ynt.2_Missense_Mutation_p.D2010Y|CSMD3_uc011lhx.1_Missense_Mutation_p.D1946Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2050	Extracellular (Potential).|Sushi 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGACAGGAATCCAAACCAATT	0.318										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	70					2.17888e-05	3.99668e-05	1	0	A	113364752	A	A	113364752	3	1	195	1	0	0	0	0	1	0	0	0	3963	855	30	2	5107	2	CSMD3	8	113364752	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	22427392	113364752	32999270	170	35920											
ZFAT	57623	broad.mit.edu	37	chr8	135612760	135612760	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagccatcggtgggacacttCagcaagatgttactgtgttt	9	12	11	9	1	1	1	1	0	0	1	2	2	1	2	1	2	3	3	1	2	2	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:135612760C>T	uc003yup.2	-	7	2569	c.2394G>A	c.(2392-2394)CTG>CTA	p.L798L	ZFAT_uc003yun.2_Silent_p.L786L|ZFAT_uc003yuo.2_Silent_p.L786L|ZFAT_uc010meh.2_Silent_p.L786L|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.L786L|ZFAT_uc010mej.2_Silent_p.L736L|ZFAT_uc003yur.2_Silent_p.L786L|ZFATAS_uc003yus.1_RNA	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	798	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGGGACACTTCAGCAAGATGT	0.438													26	109					0	0	0	0	T	135612760	T	T	135612760	2	4	195	1	0	0	0	0	0	0	0	1	17699	813	29	2		2	ZFAT	8	135612760	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	22248008	135612760	10751262	171	35921											
RHPN1	114822	broad.mit.edu	37	chr8	144464817	144464817	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgaagcacccagggtggcCgtgagggccaggatccctgc	7	6	15	13	1	0	2	0	2	0	0	1	3	1	3	4	4	2	1	4	4	1	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:144464817C>T	uc003yyb.2	+	15	2142	c.2009C>T	c.(2008-2010)CCG>CTG	p.P670L		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	695					signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CCAGGGTGGCCGTGAGGGCCA	0.687													16	14					0	0	0	0	T	144464817	T	T	144464817	3	4	195	1	0	0	0	0	1	0	0	0	13415	652	23	1	2067	1	RHPN1	8	144464817	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	8852057	144464817	1899205	172	35922											
PLEC	5339	broad.mit.edu	37	chr8	144996395	144996395	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgctgccgctgctgctcctCacgcagctgctgtgccttgg	2	11	12	16	2	1	0	1	0	0	0	2	0	2	0	3	1	7	7	3	1	0	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr8:144996395C>G	uc003zaf.1	-	32	8175	c.8005G>C	c.(8005-8007)GAG>CAG	p.E2669Q	PLEC_uc003zab.1_Missense_Mutation_p.E2532Q|PLEC_uc003zac.1_Missense_Mutation_p.E2536Q|PLEC_uc003zad.2_Missense_Mutation_p.E2532Q|PLEC_uc003zae.1_Missense_Mutation_p.E2500Q|PLEC_uc003zag.1_Missense_Mutation_p.E2510Q|PLEC_uc003zah.2_Missense_Mutation_p.E2518Q|PLEC_uc003zaj.2_Missense_Mutation_p.E2559Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2669	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						tgctgctCCTCACGCAGCTGC	0.517													3	12					0	0	0	0	G	144996395	G	G	144996395	3	3	195	1	0	0	0	0	1	0	0	0	12107	835	29	2	6053	2	PLEC	8	144996395	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	531578	144996395	1367627	173	35923											
SLC39A4	55630	broad.mit.edu	37	chr8	145640760	145640760	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcactgcccggagcccccGcccccaccgcctcctccagc	5	3	8	25	3	0	0	0	0	0	0	2	1	2	1	9	1	4	1	9	1	0	0	rs141890870	byFrequency	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	1d01e739-6907-47d2-8b4b-d8babe8066ca	g.chr8:145640760G>T	uc003zcq.2	-	3	618	c.518C>A	c.(517-519)GCG>GAG	p.A173E	SLC39A4_uc003zcm.1_5'Flank|SLC39A4_uc003zcn.2_5'Flank|SLC39A4_uc003zco.2_Splice_Site|SLC39A4_uc003zcp.2_Missense_Mutation_p.A148E	NM_130849	NP_570901	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter),	173	Extracellular (Potential).					cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			CGGAGCCCCCGCCCCCACCGC	0.682													7	12					2.7689e-08	5.1752e-08	1	0	T	145640760	T	T	145640760	3	4	195	1	0	0	0	0	1	0	0	0	14684	1087	38	3	1465	3	SLC39A4	8	145640760	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	644365	145640760	723262	174	35924											
PSIP1	11168	broad.mit.edu	37	chr9	15469058	15469058	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caatgcatctgttcacatccTtcatgacaaaacagtaattt	14	13	4	10	0	3	1	2	1	1	0	4	1	4	1	1	0	2	3	1	0	4	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:15469058T>C	uc003zlv.3	-	13	1435	c.1105_splice	c.e13-1	p.D369_splice	PSIP1_uc003zlw.3_Splice_Site_p.D369_splice	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2						initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		GTTCACATCCTTCATGACAAA	0.353													11	18					0	0	0	0	C	15469058	C	C	15469058	5	2	195	1	0	0	0	0	0	0	1	0	12725	1623	56	5	505	5	PSIP1	9	15469058	Splice_Site	SNP	T	TCGA-CV-6936-01A-11D-1912-08		15469058	125744373	175	35925											
DCAF12	25853	broad.mit.edu	37	chr9	34098412	34098412	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctttaaggccttgtgagtGatgtgtgcatacacagggac	9	12	12	8	0	0	2	0	2	0	0	1	3	1	3	2	2	2	1	2	2	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:34098412G>C	uc003ztt.2	-	5	1047	c.705C>G	c.(703-705)ATC>ATG	p.I235M		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	235						centrosome|CUL4 RING ubiquitin ligase complex					0						CCTTGTGAGTGATGTGTGCAT	0.483													7	108					0	0	0	0	C	34098412	C	C	34098412	3	2	195	1	0	0	0	0	1	0	0	0	4280	1280	45	2	676	2	DCAF12	9	34098412	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	18629354	34098412	107115019	176	35926											
C9orf79	286234	broad.mit.edu	37	chr9	90502856	90502856	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactcaagcccctctgtccAcctcccagagtgtgtctggt	6	10	8	17	0	3	1	1	0	2	1	5	1	5	1	6	1	1	0	6	1	1	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:90502856A>G	uc004app.3	+	4	3489	c.3454A>G	c.(3454-3456)ACC>GCC	p.T1152A		NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	1152						integral to membrane				ovary(3)	3						CCCTCTGTCCACCTCCCAGAG	0.642													8	32					0	0	0	0	G	90502856	G	G	90502856	3	3	195	1	0	0	0	0	1	0	0	0	2509	159	6	5	3468	5	C9orf79	9	90502856	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	56404444	90502856	50710575	177	35927											
KIAA1529	57653	broad.mit.edu	37	chr9	100136864	100136864	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaattatcaatgctcatacGaaggaaactcgctgggctct	13	10	9	9	2	3	0	2	0	1	0	4	3	3	1	0	2	3	3	0	2	6	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:100136864G>A	uc011lut.1	+	47	5962	c.5189G>A	c.(5188-5190)CGA>CAA	p.R1730Q	KIAA1529_uc004axe.1_Missense_Mutation_p.R1536Q|KIAA1529_uc004axg.1_Missense_Mutation_p.R1591Q|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.R684Q	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				ATGCTCATACGAAGGAAACTC	0.507													4	22					0	0	0	0	A	100136864	A	A	100136864	3	1	195	1	0	0	0	0	1	0	0	0	8279	1058	37	1	4749	1	KIAA1529	9	100136864	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	9634008	100136864	41076567	178	35928											
SVEP1	79987	broad.mit.edu	37	chr9	113169482	113169482	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacatatccggggtcacactCatagtacaacgtgctcaggt	11	9	9	12	2	3	0	3	0	0	0	4	0	4	0	1	3	3	2	1	3	4	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:113169482C>G	uc010mtz.2	-	38	8735	c.8398G>C	c.(8398-8400)GAG>CAG	p.E2800Q	SVEP1_uc010mty.2_Missense_Mutation_p.E726Q	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2800	Sushi 23.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GGGTCACACTCATAGTACAAC	0.483													76	52					0	0	0	0	G	113169482	G	G	113169482	3	3	195	1	0	0	0	0	1	0	0	0	15486	835	29	2	2361	2	SVEP1	9	113169482	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	13032618	113169482	28043949	179	35929											
LAMC3	10319	broad.mit.edu	37	chr9	133957539	133957539	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagccaggactctgctggctGatctggaaggtacgtgagtc	8	9	15	9	1	2	2	0	2	2	0	3	5	2	4	1	4	3	3	1	4	2	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:133957539G>C	uc004caa.1	+	24	4119	c.4021G>C	c.(4021-4023)GAT>CAT	p.D1341H	LAMC3_uc010mze.1_Missense_Mutation_p.D57H	NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1341	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TCTGCTGGCTGATCTGGAAGG	0.617													13	5					0	0	0	0	C	133957539	C	C	133957539	3	2	195	1	0	0	0	0	1	0	0	0	8656	1290	45	2	4115	2	LAMC3	9	133957539	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	20788057	133957539	7255892	180	35930											
C9orf96	169436	broad.mit.edu	37	chr9	136253248	136253248	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagatctcttctctgtacctCtgcctggtgatggagttcaa	7	14	9	11	0	4	2	1	1	3	1	6	3	4	3	2	2	2	2	2	2	2	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:136253248C>G	uc004cdk.2	+	5	373	c.312C>G	c.(310-312)CTC>CTG	p.L104L	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	104	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CTCTGTACCTCTGCCTGGTGA	0.572													12	55					0	0	0	0	G	136253248	G	G	136253248	2	3	195	1	0	0	0	0	0	0	0	1	2520	900	32	2		2	C9orf96	9	136253248	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	2295709	136253248	4960183	181	35931											
PHPT1	29085	broad.mit.edu	37	chr9	139744530	139744530	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgactgtgagtgtctgggcGgcgggcgcatctcccaccag	5	7	16	13	4	2	1	0	1	2	0	3	2	2	1	2	3	0	1	2	3	0	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:139744530G>A	uc004cjp.2	+	3	848	c.226G>A	c.(226-228)GGC>AGC	p.G76S	PHPT1_uc011mei.1_Missense_Mutation_p.G76S|PHPT1_uc004cjq.3_Missense_Mutation_p.G76S|MAMDC4_uc004cjs.2_5'Flank|MAMDC4_uc011mej.1_5'Flank	NM_014172	NP_054891	Q9NRX4	PHP14_HUMAN	phosphohistidine phosphatase 1 isoform 3	76						cytosol	phosphohistidine phosphatase activity|phosphoprotein phosphatase activity				0	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		GTGTCTGGGCGGCGGGCGCAT	0.647													47	20					0	0	0	0	A	139744530	A	A	139744530	3	1	195	1	0	0	0	0	1	0	0	0	11915	1116	39	1	232	1	PHPT1	9	139744530	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	3491282	139744530	1468901	182	35932											
C8G	733	broad.mit.edu	37	chr9	139840948	139840948	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgtgagcgactcggtcctGagtgggtttgagcagcgggt	5	10	17	9	3	0	3	0	3	0	0	2	4	1	3	2	3	3	2	2	3	0	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:139840948G>C	uc004cka.2	+	5	561	c.486G>C	c.(484-486)CTG>CTC	p.L162L	FBXW5_uc004cjx.2_5'Flank|FBXW5_uc004cjy.2_5'Flank|FBXW5_uc004cjz.2_5'Flank	NM_000606	NP_000597	P07360	CO8G_HUMAN	complement component 8, gamma polypeptide	162					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex	retinol binding|transporter activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.88e-06)|Epithelial(140;0.000107)		ACTCGGTCCTGAGTGGGTTTG	0.657													3	19					0	0	0	0	C	139840948	C	C	139840948	2	2	195	1	0	0	0	0	0	0	0	1	2429	1277	45	2		2	C8G	9	139840948	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	96418	139840948	1372483	183	35933											
RNF208	727800	broad.mit.edu	37	chr9	140115259	140115259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccaggggctcgcctgccgCcgccgaagaagccgccgagg	6	3	15	17	6	0	1	0	0	0	1	2	3	1	1	7	3	2	1	7	3	2	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr9:140115259C>T	uc004clz.1	-	1	517	c.406G>A	c.(406-408)GCG>ACG	p.A136T		NM_031297	NP_112587	Q9H0X6	RN208_HUMAN	ring finger protein 208	136							zinc ion binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TCGCCTGCCGCCGCCGAAGAA	0.672													23	11					0	0	0	0	T	140115259	T	T	140115259	3	4	195	1	0	0	0	0	1	0	0	0	13540	739	26	4	383	4	RNF208	9	140115259	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	274311	140115259	1098172	184	35934											
LYZL1	84569	broad.mit.edu	37	chr10	29599073	29599073	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacctcacagatgcaattatCtgtgccaggaaaattgttaa	14	11	8	8	0	2	1	1	0	1	1	2	3	2	2	2	1	2	2	2	1	5	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:29599073C>T	uc001iul.2	+	4	528	c.471C>T	c.(469-471)ATC>ATT	p.I157I		NM_032517	NP_115906	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	111					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Breast(68;0.203)				ATGCAATTATCTGTGCCAGGA	0.433													12	30					0	0	0	0	T	29599073	T	T	29599073	2	4	195	1	0	0	0	0	0	0	0	1	9182	903	32	2		2	LYZL1	10	29599073	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08		29599073	105935674	185	35935											
ANK3	288	broad.mit.edu	37	chr10	62149197	62149197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agatacctttttcttccgatCccgggaccgtttgcggtgtt	5	15	10	11	4	1	1	0	0	1	1	3	3	3	2	4	2	2	2	4	2	1	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:62149197C>T	uc001jky.2	-	1	292	c.100G>A	c.(100-102)GAT>AAT	p.D34N	ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jlb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	34					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTCTTCCGATCCCGGGACCGT	0.408													15	60					0	0	0	0	T	62149197	T	T	62149197	3	4	195	1	0	0	0	0	1	0	0	0	622	855	30	2	13538	2	ANK3	10	62149197	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	32550124	62149197	73385550	186	35936											
ADAMTS14	140766	broad.mit.edu	37	chr10	72500862	72500862	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcagtgtgccaagcgcaactCctactatgtgcaccagaatg	11	8	10	12	1	0	1	0	0	0	1	1	1	1	1	3	0	5	3	3	0	5	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:72500862C>T	uc001jrh.2	+	12	1868	c.1868C>T	c.(1867-1869)TCC>TTC	p.S623F	ADAMTS14_uc001jrg.2_Missense_Mutation_p.S626F|ADAMTS14_uc001jri.1_Missense_Mutation_p.S146F	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	623	Cys-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						AAGCGCAACTCCTACTATGTG	0.617													13	33					0	0	0	0	T	72500862	T	T	72500862	3	4	195	1	0	0	0	0	1	0	0	0	259	855	30	2	1923	2	ADAMTS14	10	72500862	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	10351665	72500862	63033885	187	35937											
C10orf58	84293	broad.mit.edu	37	chr10	82187156	82187156	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atccgtctgggagtgtggtaCaacttcttccgagcctggaa	8	11	12	10	2	2	0	0	0	2	0	4	3	4	2	3	3	3	1	3	3	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:82187156C>G	uc001kcc.3	+	5	640	c.480C>G	c.(478-480)TAC>TAG	p.Y160*	C10orf58_uc001kcd.3_Nonsense_Mutation_p.Y149*|C10orf58_uc001kce.3_Nonsense_Mutation_p.Y160*|C10orf58_uc001kcf.3_Nonsense_Mutation_p.Y160*	NM_032333	NP_115709	Q9BRX8	CJ058_HUMAN	hypothetical protein LOC84293 precursor	160						extracellular region					0			Colorectal(32;0.229)			GAGTGTGGTACAACTTCTTCC	0.488													4	61					0	0	0	0	G	82187156	G	G	82187156	4	3	195	1	0	0	0	0	0	1	0	0	1616	489	17	4	494	4	C10orf58	10	82187156	Nonsense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	9686294	82187156	53347591	188	35938											
PLCE1	51196	broad.mit.edu	37	chr10	95892130	95892130	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgcagtacatcaccggttCtctcctagaagcaaccacgt	11	9	7	14	3	2	1	1	0	1	1	5	1	3	1	3	1	3	4	3	1	4	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:95892130C>T	uc001kjk.2	+	3	2040	c.1406C>T	c.(1405-1407)TCT>TTT	p.S469F	PLCE1_uc010qnx.1_Missense_Mutation_p.S469F|PLCE1_uc001kjm.2_Missense_Mutation_p.S161F	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	469					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				ATCACCGGTTCTCTCCTAGAA	0.478													7	94					0	0	0	0	T	95892130	T	T	95892130	3	4	195	1	0	0	0	0	1	0	0	0	12089	913	32	2	1698	2	PLCE1	10	95892130	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	13704974	95892130	39642617	189	35939											
ENTPD7	57089	broad.mit.edu	37	chr10	101451214	101451214	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agggatactggatatgggagGagcctctctccaaattgctt	10	11	12	8	0	1	0	0	0	1	0	3	4	2	4	2	4	3	1	2	4	3	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:101451214G>A	uc001kqa.3	+	8	960	c.782G>A	c.(781-783)GGA>GAA	p.G261E	ENTPD7_uc009xwl.2_Missense_Mutation_p.G263E	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	261	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		GATATGGGAGGAGCCTCTCTC	0.453													7	37					0	0	0	0	A	101451214	A	A	101451214	3	1	195	1	0	0	0	0	1	0	0	0	5168	1174	41	2	808	2	ENTPD7	10	101451214	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	5559084	101451214	34083533	190	35940											
PNLIPRP2	5408	broad.mit.edu	37	chr10	118394400	118394400	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctaagaagcttcgagtattActcaagcagcgtcctcaacc	12	9	7	13	2	2	1	2	0	0	1	4	2	3	1	3	0	5	3	3	0	6	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr10:118394400A>T	uc001lcq.2	+	11	892	c.869A>T	c.(868-870)TAC>TTC	p.Y290F	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	289					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		TTCGAGTATTACTCAAGCAGC	0.498													7	34					0	0	0	0	T	118394400	T	T	118394400	3	4	195	1	0	0	0	0	1	0	0	0	12206	391	14	5	902	5	PNLIPRP2	10	118394400	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	16943186	118394400	17140347	191	35941											
PHRF1	57661	broad.mit.edu	37	chr11	587346	587346	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccgctggctctttcaattCtgatgatgatgcagagagct	9	12	11	9	1	3	4	1	3	2	1	3	5	3	4	1	1	3	4	1	1	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:587346C>G	uc001lqe.2	+	4	433	c.302C>G	c.(301-303)TCT>TGT	p.S101C	PHRF1_uc010qwc.1_Missense_Mutation_p.S101C|PHRF1_uc010qwd.1_Missense_Mutation_p.S100C|PHRF1_uc010qwe.1_Missense_Mutation_p.S97C	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	101							RNA polymerase binding|zinc ion binding				0						TCTTTCAATTCTGATGATGAT	0.562													17	31					0	0	0	0	G	587346	G	G	587346	3	3	195	1	0	0	0	0	1	0	0	0	11916	913	32	2	312	2	PHRF1	11	587346	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08		587346	134419170	192	35942											
MUC5B	727897	broad.mit.edu	37	chr11	1157901	1157901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcagtgcacccatgcaggggGgttgccccaggactggcggg	6	5	18	12	1	0	0	0	0	0	0	0	1	0	1	3	6	3	4	3	6	0	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:1157901G>A	uc009ycr.1	+	9	1094	c.968G>A	c.(967-969)GGG>GAG	p.G323E		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	314					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CATGCAGGGGGGTTGCCCCAG	0.667													10	31					0	0	0	0	A	1157901	A	A	1157901	3	1	195	1	0	0	0	0	1	0	0	0	10032	1247	43	4		4	MUC5B	11	1157901	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	570555	1157901	133848615	193	35943											
NELL1	4745	broad.mit.edu	37	chr11	21592401	21592402	+	Frame_Shift_Ins	INS	-	A	A																															gaatgtgacaccagagtcacINSaagtcaatgtttagaccaaa																										TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:21592401_21592402insA	uc001mqe.2	+	18	2225_2226	c.2072_2073insA	c.(2071-2073)ACAfs	p.T691fs	NELL1_uc001mqf.2_Frame_Shift_Ins_p.T644fs|NELL1_uc009yid.2_Frame_Shift_Ins_p.T719fs|NELL1_uc010rdo.1_Frame_Shift_Ins_p.T634fs|NELL1_uc010rdp.1_Frame_Shift_Ins_p.T404fs|NELL1_uc001mqh.2_Frame_Shift_Ins_p.T236fs	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	691					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						ACCAGAGTCACAAGTCAATGTT	0.47													---	---	---								A	21592402	A	A	21592401	7	5	195	1	0	1	1	0	0	0	0	0	10387	478	17	0	2142	0	NELL1	11	21592401	Frame_Shift_Ins	INS	-	TCGA-CV-6936-01A-11D-1912-08	20434500	21592401	113414115	194	35944											
LRRC4C	57689	broad.mit.edu	37	chr11	40137497	40137497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accattgaaagccccaatttCaatggttctgatatggttcc	11	13	7	10	0	2	2	1	2	1	0	3	2	3	2	4	2	1	2	4	2	4	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:40137497C>T	uc001mxa.1	-	2	2310	c.346G>A	c.(346-348)GAA>AAA	p.E116K	LRRC4C_uc001mxc.1_Missense_Mutation_p.E112K|LRRC4C_uc001mxd.1_Missense_Mutation_p.E112K|LRRC4C_uc001mxb.1_Missense_Mutation_p.E112K	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	116	LRR 2.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GCCCCAATTTCAATGGTTCTG	0.428													11	58					0	0	0	0	T	40137497	T	T	40137497	3	4	195	1	0	0	0	0	1	0	0	0	9058	835	29	2	1580	2	LRRC4C	11	40137497	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	18545096	40137497	94869019	195	35945											
OR5AR1	219493	broad.mit.edu	37	chr11	56431302	56431302	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gggaatattggtatgattatCctgattacaacagacactca	14	12	8	7	0	1	3	1	2	0	1	2	4	2	4	1	2	2	1	1	2	6	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:56431302C>G	uc010rjm.1	+	1	141	c.141C>G	c.(139-141)ATC>ATG	p.I47M		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTATGATTATCCTGATTACAA	0.473													10	183					0	0	0	0	G	56431302	G	G	56431302	3	3	195	1	0	0	0	0	1	0	0	0	11199	845	30	2	143	2	OR5AR1	11	56431302	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	16293805	56431302	78575214	196	35946											
MS4A6E	245802	broad.mit.edu	37	chr11	60107412	60107418	+	Frame_Shift_Del	DEL	GGAAACA	-	-																															gctcactgctgtgctgcagtGgaaacagactgtctgacttc																										TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:60107412_60107418delGGAAACA	uc001npd.2	+	3	442_448	c.428_434delGGAAACA	c.(427-435)TGGAAACAGfs	p.W143fs		NM_139249	NP_640342	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member	143_145	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						GTGCTGCAGTGGAAACAGACTGTCTGA	0.478													---	---	---								-	60107418	-	-	60107412	7	5	195	1	0	1	0	1	0	0	0	0	9918	1357	47	0	438	0	MS4A6E	11	60107412	Frame_Shift_Del	DEL	GGAAACA	TCGA-CV-6936-01A-11D-1912-08	3676110	60107412	74899104	197	35947											
NRXN2	9379	broad.mit.edu	37	chr11	64428240	64428240	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacctctctcacagacccGcccaagaaagccggtcccga	10	5	7	19	3	3	2	2	0	1	2	5	3	4	2	5	1	1	0	5	1	2	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:64428240G>A	uc001oar.2	-	11	2609	c.2170C>T	c.(2170-2172)CGG>TGG	p.R724W	NRXN2_uc001oas.2_Missense_Mutation_p.R693W|NRXN2_uc001oaq.2_Missense_Mutation_p.R391W	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						TCACAGACCCGCCCAAGAAAG	0.592													17	45					0	0	0	0	A	64428240	A	A	64428240	3	1	195	1	0	0	0	0	1	0	0	0	10720	1086	38	1	3293	1	NRXN2	11	64428240	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	4320828	64428240	70578276	198	35948											
RELT	84957	broad.mit.edu	37	chr11	73106303	73106303	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagccgtacaaagtggctGaagcccccagcagagaacaa	15	3	12	11	1	0	2	0	1	0	1	0	4	0	3	3	2	5	3	3	2	6	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:73106303G>A	uc001otv.2	+	10	1383	c.1218G>A	c.(1216-1218)CTG>CTA	p.L406L	RELT_uc001otw.2_Silent_p.L406L|RELT_uc001otx.2_RNA	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	406	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						CAAAGTGGCTGAAGCCCCCAG	0.642													5	105					0	0	0	0	A	73106303	A	A	73106303	2	1	195	1	0	0	0	0	0	0	0	1	13286	1277	45	2		2	RELT	11	73106303	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	8678063	73106303	61900213	199	35949											
SLC36A4	120103	broad.mit.edu	37	chr11	92918982	92918982	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcctcattacatccatatcTttaaaaaagaaaaacaaagt	19	10	4	8	0	2	1	1	0	1	1	3	1	3	1	2	1	2	0	2	1	8	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:92918982T>A	uc001pdn.2	-	2	153	c.56_splice	c.e2-1	p.D19_splice	SLC36A4_uc001pdm.2_Splice_Site	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid						L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CATCCATATCTTTAAAAAAGA	0.333													9	13					0	0	0	0	A	92918982	A	A	92918982	5	1	195	1	0	0	0	0	0	0	1	0	14660	1623	56	5	1500	5	SLC36A4	11	92918982	Splice_Site	SNP	T	TCGA-CV-6936-01A-11D-1912-08	19812679	92918982	42087534	200	35950											
IL10RA	3587	broad.mit.edu	37	chr11	117864051	117864051	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagatggcccccgcaaatGacacatatgaaagcatcttc	14	7	7	13	1	1	3	0	2	1	1	2	3	1	3	3	1	1	2	3	1	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr11:117864051G>T	uc001prv.2	+	4	540	c.463G>T	c.(463-465)GAC>TAC	p.D155Y	IL10RA_uc010rxl.1_Missense_Mutation_p.D135Y|IL10RA_uc010rxm.1_Missense_Mutation_p.D135Y|IL10RA_uc010rxn.1_Missense_Mutation_p.D6Y|IL10RA_uc001prw.2_Missense_Mutation_p.D6Y	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	155	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CCCCGCAAATGACACATATGA	0.527													4	38					0.00024832	0.000452902	1	0	T	117864051	T	T	117864051	3	4	195	1	0	0	0	0	1	0	0	0	7659	1290	45	2	477	2	IL10RA	11	117864051	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	24945069	117864051	17142465	201	35951											
YARS2	51067	broad.mit.edu	37	chr12	32908286	32908286	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgctgcttctggtaccaggCcgagttgtccagcacagtga	7	10	13	11	1	1	1	0	1	1	0	2	2	2	1	3	2	4	5	3	2	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:32908286C>A	uc001rli.2	-	1	589	c.523G>T	c.(523-525)GCC>TCC	p.A175S		NM_001040436	NP_001035526	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	175					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity				0	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	TGGTACCAGGCCGAGTTGTCC	0.657											OREG0021729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	22					0.000566183	0.00102681	1	0	A	32908286	A	A	32908286	3	1	195	1	0	0	0	0	1	0	0	0	17536	739	26	4	930	4	YARS2	12	32908286	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08		32908286	100943609	202	35952											
DDN	23109	broad.mit.edu	37	chr12	49392252	49392252	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtcgacccggggggctccgtCgggccccaccagccttgcgc	3	5	15	18	5	0	0	0	0	0	0	3	1	1	0	6	4	2	1	6	4	0	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:49392252C>G	uc001rsv.1	-	2	425	c.407G>C	c.(406-408)CGA>CCA	p.R136P	uc001rsw.2_5'UTR	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	136						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						GGGGCTCCGTCGGGCCCCACC	0.741													6	13					0	0	0	0	G	49392252	G	G	49392252	3	3	195	1	0	0	0	0	1	0	0	0	4350	884	31	3	1732	3	DDN	12	49392252	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	16483966	49392252	84459643	203	35953											
SLC4A8	9498	broad.mit.edu	37	chr12	51851325	51851325	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catttgatggataaacatggTaagattattaggtgattttt	13	17	9	2	0	0	3	0	2	0	1	0	4	0	4	0	3	1	1	0	3	5	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:51851325T>C	uc001rys.1	+	6	941	c.763_splice	c.e6+2	p.G255_splice	SLC4A8_uc010sni.1_Splice_Site_p.G202_splice|SLC4A8_uc001rym.2_Splice_Site_p.G202_splice|SLC4A8_uc001ryn.2_Splice_Site_p.G202_splice|SLC4A8_uc001ryo.2_Splice_Site_p.G202_splice|SLC4A8_uc001ryp.1_Splice_Site_p.G202_splice|SLC4A8_uc010snj.1_Splice_Site_p.G282_splice|SLC4A8_uc001ryq.3_Splice_Site_p.G255_splice|SLC4A8_uc001ryr.2_Splice_Site_p.G255_splice|SLC4A8_uc010snk.1_Splice_Site_p.G202_splice	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate						bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		ATAAACATGGTAAGATTATTA	0.388													17	33					0	0	0	0	C	51851325	C	C	51851325	5	2	195	1	0	0	0	0	0	0	1	0	14723	1652	57	5	787	5	SLC4A8	12	51851325	Splice_Site	SNP	T	TCGA-CV-6936-01A-11D-1912-08	2459073	51851325	82000570	204	35954											
SCN8A	6334	broad.mit.edu	37	chr12	52201213	52201213	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcagagaatccaagtgttaGaggagaacaaaaattcagta	18	8	10	5	0	2	3	2	0	0	3	3	5	3	3	1	1	1	2	1	1	7	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:52201213G>C	uc001ryw.2	+	27	6121	c.5943G>C	c.(5941-5943)TAG>TAC	p.*1981Y	uc001rzb.1_5'Flank	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1981					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CCAAGTGTTAGAGGAGAACAA	0.393													2	4					0	0	0	0	C	52201213	C	C	52201213	4	2	195	1	0	0	0	0	0	0	0	0	13989	937	33	2	6045	2	SCN8A	12	52201213	Nonstop_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	349888	52201213	81650682	205	35955											
GLI1	2735	broad.mit.edu	37	chr12	57863427	57863427	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaggctggaccagctacatCaactccggccaatagggacc	11	6	10	14	1	2	0	2	0	0	0	3	2	3	2	4	4	3	2	4	4	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:57863427C>G	uc001snx.2	+	11	1600	c.1522C>G	c.(1522-1524)CAA>GAA	p.Q508E	GLI1_uc009zpq.2_Missense_Mutation_p.Q380E	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	508					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CCAGCTACATCAACTCCGGCC	0.607													10	60					0	0	0	0	G	57863427	G	G	57863427	3	3	195	1	0	0	0	0	1	0	0	0	6474	827	29	2	1560	2	GLI1	12	57863427	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	5662214	57863427	75988468	206	35956											
SYT1	6857	broad.mit.edu	37	chr12	79689943	79689943	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtgtttctgctacctgataAgaagaagaaatttgagacaa	16	11	9	5	0	1	5	0	2	1	4	1	6	1	5	1	0	2	2	1	0	6	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:79689943A>T	uc001sys.2	+	8	1240	c.569A>T	c.(568-570)AAG>ATG	p.K190M	SYT1_uc001syt.2_Missense_Mutation_p.K190M|SYT1_uc001syu.2_Missense_Mutation_p.K187M|SYT1_uc001syv.2_Missense_Mutation_p.K190M	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	190	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 1.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						CTACCTGATAAGAAGAAGAAA	0.418													20	42					0	0	0	0	T	79689943	T	T	79689943	3	4	195	1	0	0	0	0	1	0	0	0	15531	72	3	5	583	5	SYT1	12	79689943	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	21826516	79689943	54161952	207	35957											
PAWR	5074	broad.mit.edu	37	chr12	79988212	79988212	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgtctttctcttactactTcctggtagatacaattaaaa	11	17	4	9	0	2	1	0	0	2	1	4	1	3	1	1	1	3	1	1	1	7	8			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:79988212T>A	uc001syx.2	-	6	1119	c.833A>T	c.(832-834)GAA>GTA	p.E278V		NM_002583	NP_002574	Q96IZ0	PAWR_HUMAN	PRKC, apoptosis, WT1, regulator	278					actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity				0						TCTTACTACTTCCTGGTAGAT	0.294													8	16					0	0	0	0	A	79988212	A	A	79988212	3	1	195	1	0	0	0	0	1	0	0	0	11531	1797	62	5	197	5	PAWR	12	79988212	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	298269	79988212	53863683	208	35958											
ACSS3	79611	broad.mit.edu	37	chr12	81503457	81503457	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttacaaacactaaagcaaccTttacctataaagaagttctg	17	11	4	9	0	1	1	0	0	1	1	1	1	1	1	2	0	5	2	2	0	10	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:81503457T>A	uc001szl.1	+	2	521	c.430T>A	c.(430-432)TTT>ATT	p.F144I	ACSS3_uc001szm.1_Missense_Mutation_p.F143I	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	144						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TAAAGCAACCTTTACCTATAA	0.299													7	25					0	0	0	0	A	81503457	A	A	81503457	3	1	195	1	0	0	0	0	1	0	0	0	190	1609	56	5	436	5	ACSS3	12	81503457	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	1515245	81503457	52348438	209	35959											
EEA1	8411	broad.mit.edu	37	chr12	93213152	93213152	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtctctccttcaccagcctGaatttttgcataaagatctt	10	15	5	11	0	3	2	1	1	2	1	5	2	4	2	3	0	2	1	3	0	3	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:93213152G>C	uc001tck.2	-	14	1925	c.1660C>G	c.(1660-1662)CAG>GAG	p.Q554E		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	554	Gln/Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TCACCAGCCTGAATTTTTGCA	0.313													6	30					0	0	0	0	C	93213152	C	C	93213152	3	2	195	1	0	0	0	0	1	0	0	0	4943	1299	45	2	2639	2	EEA1	12	93213152	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	11709695	93213152	40638743	210	35960											
ANO4	121601	broad.mit.edu	37	chr12	101510564	101510564	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgagttctcggggactcctcTtaagtactgcaggtgagtgt	7	13	13	8	1	2	2	0	2	2	0	4	3	3	3	1	3	2	3	1	3	2	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:101510564T>C	uc010svm.1	+	25	3130	c.2558T>C	c.(2557-2559)CTT>CCT	p.L853P	ANO4_uc001thw.2_Missense_Mutation_p.L818P|ANO4_uc001thx.2_Missense_Mutation_p.L853P|ANO4_uc001thy.2_Missense_Mutation_p.L373P	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	853	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GGGACTCCTCTTAAGTACTGC	0.542										HNSCC(74;0.22)			4	81					0	0	0	0	C	101510564	C	C	101510564	3	2	195	1	0	0	0	0	1	0	0	0	699	1609	56	5	2543	5	ANO4	12	101510564	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	8297412	101510564	32341331	211	35961											
UTP20	27340	broad.mit.edu	37	chr12	101779782	101779782	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atattgctgccaagaaaaaaAtgaagaaacacaaaaataaa	25	6	5	5	0	0	3	0	1	0	2	0	3	0	3	1	0	3	1	1	0	11	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:101779782A>G	uc001tia.1	+	62	8395	c.8239A>G	c.(8239-8241)ATG>GTG	p.M2747V		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2747	Nuclear localization signal.|Potential.|Nucleolar localization signal.				endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						CAAGAAAAAAATGAAGAAACA	0.308													23	51					0	0	0	0	G	101779782	G	G	101779782	3	3	195	1	0	0	0	0	1	0	0	0	17167	101	4	5	8485	5	UTP20	12	101779782	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	269218	101779782	32072113	212	35962											
MYBPC1	4604	broad.mit.edu	37	chr12	102036248	102036248	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggacgtatgggagttgctGaagaacgcgaaacccagtga	12	7	15	7	3	0	3	0	2	0	1	0	6	0	5	1	2	3	3	1	2	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:102036248G>A	uc001tii.2	+	9	744	c.642G>A	c.(640-642)CTG>CTA	p.L214L	MYBPC1_uc001tif.1_Silent_p.L227L|MYBPC1_uc001tig.2_Silent_p.L239L|MYBPC1_uc010svq.1_Silent_p.L201L|MYBPC1_uc001tih.2_Silent_p.L239L|MYBPC1_uc001tij.2_Silent_p.L214L|MYBPC1_uc010svr.1_Silent_p.L214L|MYBPC1_uc010svs.1_Silent_p.L214L|MYBPC1_uc010svt.1_Silent_p.L202L|MYBPC1_uc010svu.1_Silent_p.L195L|MYBPC1_uc001tik.2_Silent_p.L188L	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	214					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GGGAGTTGCTGAAGAACGCGA	0.562													15	43					0	0	0	0	A	102036248	A	A	102036248	2	1	195	1	0	0	0	0	0	0	0	1	10064	1277	45	2		2	MYBPC1	12	102036248	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	256466	102036248	31815647	213	35963											
ATP2A2	488	broad.mit.edu	37	chr12	110764234	110764234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caagcacactgatcccgtccCtgacccacgagctgtcaacc	10	6	7	18	2	1	2	1	2	0	0	3	3	3	2	4	0	3	2	4	0	2	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:110764234C>T	uc001tqk.3	+	7	1147	c.584C>T	c.(583-585)CCT>CTT	p.P195L	ATP2A2_uc001tql.3_Missense_Mutation_p.P195L|ATP2A2_uc010sxy.1_Missense_Mutation_p.P168L	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	195	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						GATCCCGTCCCTGACCCACGA	0.423													4	25					0	0	0	0	T	110764234	T	T	110764234	3	4	195	1	0	0	0	0	1	0	0	0	1139	681	24	4	610	4	ATP2A2	12	110764234	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	8727986	110764234	23087661	214	35964											
SBNO1	55206	broad.mit.edu	37	chr12	123780467	123780467	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgttcttcatgcgttgctCaagttggtgatgctctgagg	5	16	12	8	1	5	2	2	2	3	0	5	2	5	2	0	2	3	5	0	2	1	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr12:123780467C>G	uc010tap.1	-	31	4170	c.4170G>C	c.(4168-4170)TTG>TTC	p.L1390F	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.L1389F|SBNO1_uc010taq.1_Missense_Mutation_p.L341F	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1390							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ATGCGTTGCTCAAGTTGGTGA	0.428													8	257					0	0	0	0	G	123780467	G	G	123780467	3	3	195	1	0	0	0	0	1	0	0	0	13927	825	29	2	15	2	SBNO1	12	123780467	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	13016233	123780467	10071428	215	35965											
GJB2	2706	broad.mit.edu	37	chr13	20763385	20763385	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgatgtccttaaattcactCtttatctcccccttgatgaa	9	16	4	12	1	3	2	1	2	2	0	6	3	4	2	3	0	0	0	3	0	4	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:20763385C>T	uc001umy.2	-	2	551	c.336G>A	c.(334-336)AAG>AAA	p.K112K		NM_004004	NP_003995	P29033	CXB2_HUMAN	gap junction protein beta 2	112	Cytoplasmic (Potential).			K -> N (in Ref. 4; AAY25170).	cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane					0		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		TAAATTCACTCTTTATCTCCC	0.532									Keratitis_Ichthyosis_and_Deafness_syndrome		OREG0022282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	57					0	0	0	0	T	20763385	T	T	20763385	2	4	195	1	0	0	0	0	0	0	0	1	6445	912	32	2		2	GJB2	13	20763385	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08		20763385	94406493	216	35966											
FRY	10129	broad.mit.edu	37	chr13	32869543	32869543	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atccgcagggcccagagttaCcgagtcctcactacttttct	8	11	8	14	2	2	1	1	0	1	1	4	2	4	1	4	1	2	2	4	1	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:32869543C>A	uc001utx.2	+	61	9484	c.8988C>A	c.(8986-8988)TAC>TAA	p.Y2996*	FRY_uc010tdw.1_RNA|FRY_uc001utz.2_Nonsense_Mutation_p.Y527*|FRY_uc010tdx.1_Nonsense_Mutation_p.Y366*	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2996					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCCAGAGTTACCGAGTCCTCA	0.567													20	46					1.2644e-06	2.33933e-06	1	0	A	32869543	A	A	32869543	4	1	195	1	0	0	0	0	0	1	0	0	6097	518	18	4	9230	4	FRY	13	32869543	Nonsense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	12106158	32869543	82300335	217	35967											
BRCA2	675	broad.mit.edu	37	chr13	32950881	32950881	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgctttgcaagatggtgcaGagctttatgaagcagtgaag	11	11	14	5	0	0	4	0	2	0	2	0	4	0	4	0	1	5	5	0	1	4	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:32950881G>A	uc001uub.1	+	21	8934	c.8707G>A	c.(8707-8709)GAG>AAG	p.E2903K		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2903					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGATGGTGCAGAGCTTTATGA	0.388			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			5	26					0	0	0	0	A	32950881	A	A	32950881	3	1	195	1	0	0	0	0	1	0	0	0	1504	943	33	2	8785	2	BRCA2	13	32950881	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	81338	32950881	82218997	218	35968											
DIAPH3	81624	broad.mit.edu	37	chr13	60544172	60544172	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttatccagaaacagttttcAgtcatttcatgaggtctgat	11	16	7	7	0	4	3	3	2	1	1	5	3	5	3	1	1	1	1	1	1	2	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:60544172A>T	uc001vht.2	-	17	2199	c.1980T>A	c.(1978-1980)ACT>ACA	p.T660T	DIAPH3_uc001vhu.2_Silent_p.T397T|DIAPH3_uc001vhv.2_Silent_p.T238T	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	660	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AACAGTTTTCAGTCATTTCAT	0.353													7	7					0	0	0	0	T	60544172	T	T	60544172	2	4	195	1	0	0	0	0	0	0	0	1	4542	175	7	5		5	DIAPH3	13	60544172	Silent	SNP	A	TCGA-CV-6936-01A-11D-1912-08	27593291	60544172	54625706	219	35969											
TDRD3	81550	broad.mit.edu	37	chr13	61068665	61068665	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagttttacagaaagaaaagTcaaccaaatcagagggaaaa	22	6	8	5	0	2	3	2	0	0	3	2	4	2	4	1	1	2	1	1	1	9	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:61068665T>G	uc001via.2	+	8	1323	c.535T>G	c.(535-537)TCA>GCA	p.S179A	TDRD3_uc010aef.2_5'UTR|TDRD3_uc001vhz.3_Missense_Mutation_p.S179A|TDRD3_uc010aeg.2_Missense_Mutation_p.S272A|TDRD3_uc001vib.3_Missense_Mutation_p.S178A	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	179					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		GAAAGAAAAGTCAACCAAATC	0.363													6	36					0	0	0	0	G	61068665	G	G	61068665	3	3	195	1	0	0	0	0	1	0	0	0	15798	1667	58	5	844	5	TDRD3	13	61068665	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	524493	61068665	54101213	220	35970											
DACH1	1602	broad.mit.edu	37	chr13	72063278	72063278	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgtagaaagcggggtctCatctgcatgtgattgaaaca	11	11	13	6	1	2	3	1	2	2	1	3	3	2	3	0	3	3	2	0	3	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:72063278C>T	uc010thn.1	-	8	1996	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K	DACH1_uc010tho.1_Missense_Mutation_p.E377K|DACH1_uc010thp.1_Missense_Mutation_p.E323K	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	577					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGCGGGGTCTCATCTGCATGT	0.428													26	109					0	0	0	0	T	72063278	T	T	72063278	3	4	195	1	0	0	0	0	1	0	0	0	4237	835	29	2	567	2	DACH1	13	72063278	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	10994613	72063278	43106600	221	35971											
TBC1D4	9882	broad.mit.edu	37	chr13	75873593	75873593	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccagccacaaagctgatcCcctgacagtatcccacttct	10	9	5	17	0	1	2	0	2	1	0	4	2	4	2	5	0	2	2	5	0	2	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:75873593C>A	uc001vjl.1	-	17	3376	c.3029G>T	c.(3028-3030)GGG>GTG	p.G1010V	TBC1D4_uc010tht.1_Missense_Mutation_p.G220V|TBC1D4_uc010thu.1_Missense_Mutation_p.G167V|TBC1D4_uc010aer.2_Missense_Mutation_p.G1002V|TBC1D4_uc010aes.2_Missense_Mutation_p.G947V	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1010	Rab-GAP TBC.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		AAAGCTGATCCCCTGACAGTA	0.493													19	30					5.35356e-11	1.00204e-10	1	0	A	75873593	A	A	75873593	3	1	195	1	0	0	0	0	1	0	0	0	15688	623	22	4	887	4	TBC1D4	13	75873593	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	3810315	75873593	39296285	222	35972											
NALCN	259232	broad.mit.edu	37	chr13	101890129	101890129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagtacgtgaattgtgaatGataaagatctgggtatacat	16	12	10	3	1	1	4	0	3	1	1	1	4	1	4	0	1	2	2	0	1	8	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:101890129G>A	uc001vox.1	-	12	1600	c.1411C>T	c.(1411-1413)CAT>TAT	p.H471Y	NALCN_uc001voy.2_Missense_Mutation_p.H186Y|NALCN_uc001voz.2_Missense_Mutation_p.H471Y|NALCN_uc001vpa.2_Missense_Mutation_p.H471Y	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	471	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AATTGTGAATGATAAAGATCT	0.308													39	130					0	0	0	0	A	101890129	A	A	101890129	3	1	195	1	0	0	0	0	1	0	0	0	10201	1290	45	2	3937	2	NALCN	13	101890129	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	26016536	101890129	13279749	223	35973											
TUBGCP3	10426	broad.mit.edu	37	chr13	113223541	113223541	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagttgctgccaatcacccGcacagcatactggaactgct	11	8	9	13	1	1	0	1	0	0	0	1	2	1	1	2	1	6	5	2	1	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr13:113223541G>A	uc001vse.1	-	2	296	c.109C>T	c.(109-111)CGG>TGG	p.R37W	TUBGCP3_uc010tjq.1_Missense_Mutation_p.R37W|TUBGCP3_uc001vsf.2_Missense_Mutation_p.R37W|TUBGCP3_uc001vsg.1_Missense_Mutation_p.R37W	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	37					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CCAATCACCCGCACAGCATAC	0.433													15	42					0	0	0	0	A	113223541	A	A	113223541	3	1	195	1	0	0	0	0	1	0	0	0	16835	1086	38	1	2698	1	TUBGCP3	13	113223541	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	11333412	113223541	1946337	224	35974											
OR4Q3	441669	broad.mit.edu	37	chr14	20216405	20216405	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtggataagatattctcCttgttttacacagtgattac	10	17	7	7	0	2	2	0	1	2	1	3	3	2	3	1	1	2	1	1	1	4	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:20216405C>A	uc010tkt.1	+	1	819	c.819C>A	c.(817-819)TCC>TCA	p.S273S		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGATATTCTCCTTGTTTTACA	0.433													20	157					7.41877e-09	1.38054e-08	1	0	A	20216405	A	A	20216405	2	1	195	1	0	0	0	0	0	0	0	1	11135	668	24	4		4	OR4Q3	14	20216405	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08		20216405	87133135	225	35975											
ACIN1	22985	broad.mit.edu	37	chr14	23528491	23528491	+	Frame_Shift_Del	DEL	C	-	-																															ccgatctcggtcccccctgtCccgctccctttctctctctc																										TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:23528491delC	uc001wit.3	-	19	4220	c.3892delG	c.(3892-3894)GACfs	p.D1298fs	CDH24_uc001wil.2_5'Flank|CDH24_uc010akf.2_5'Flank|CDH24_uc001win.3_5'Flank|ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Frame_Shift_Del_p.D540fs|ACIN1_uc001wiq.3_Frame_Shift_Del_p.D540fs|ACIN1_uc001wir.3_Frame_Shift_Del_p.D571fs|ACIN1_uc001wis.3_Frame_Shift_Del_p.D979fs|ACIN1_uc010akg.2_Frame_Shift_Del_p.D1285fs	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1298	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TCCCccctgtcccgctccctt	0.478											OREG0022595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	23528491	-	-	23528491	7	5	195	1	0	1	0	1	0	0	0	0	142	855	30	0	137	0	ACIN1	14	23528491	Frame_Shift_Del	DEL	C	TCGA-CV-6936-01A-11D-1912-08	3312086	23528491	83821049	226	35976											
MYH7	4625	broad.mit.edu	37	chr14	23884302	23884302	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctccagctcattctccagctCccgcacccgcgcttccagct	5	9	6	21	3	2	0	1	0	1	0	6	0	5	0	5	0	3	5	5	0	0	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:23884302C>G	uc001wjx.2	-	37	5567	c.5461G>C	c.(5461-5463)GAG>CAG	p.E1821Q		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1821	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTCTCCAGCTCCCGCACCCGC	0.627													16	109					0	0	0	0	G	23884302	G	G	23884302	3	3	195	1	0	0	0	0	1	0	0	0	10092	864	30	2	362	2	MYH7	14	23884302	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	355811	23884302	83465238	227	35977											
KIAA0391	9692	broad.mit.edu	37	chr14	35593231	35593231	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctctccttcatcaagatgtAaacacagcttggaatttata	13	13	6	9	0	3	1	2	0	1	1	4	2	3	2	1	1	2	3	1	1	6	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:35593231A>C	uc001wsy.1	+	2	1140	c.780A>C	c.(778-780)GTA>GTC	p.V260V	KIAA0391_uc010tps.1_Silent_p.V165V|KIAA0391_uc001wsz.1_Silent_p.V260V|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Silent_p.V260V|KIAA0391_uc001wtc.1_Intron|PPP2R3C_uc001wss.2_5'Flank|PPP2R3C_uc001wst.2_5'Flank|PPP2R3C_uc010tpr.1_5'Flank|PPP2R3C_uc001wsu.2_5'Flank|PPP2R3C_uc010amn.1_5'Flank|PPP2R3C_uc001wsw.2_5'Flank|PPP2R3C_uc001wsx.1_5'Flank	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	260					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		ATCAAGATGTAAACACAGCTT	0.343													9	20					0	0	0	0	C	35593231	C	C	35593231	2	2	195	1	0	0	0	0	0	0	0	1	8211	349	13	5		5	KIAA0391	14	35593231	Silent	SNP	A	TCGA-CV-6936-01A-11D-1912-08	11708929	35593231	71756309	228	35978											
MDGA2	161357	broad.mit.edu	37	chr14	47504427	47504427	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtttaggtttgccagttaCttgacattgcagttctattg	7	18	10	6	0	1	1	0	1	1	0	1	1	1	1	1	2	3	5	1	2	3	9			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:47504427C>G	uc001wwj.3	-	8	1595	c.1399G>C	c.(1399-1401)GTA>CTA	p.V467L	MDGA2_uc001wwi.3_Missense_Mutation_p.V238L|MDGA2_uc010ani.2_Missense_Mutation_p.V27L	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	467	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TTGCCAGTTACTTGACATTGC	0.413													32	75					0	0	0	0	G	47504427	G	G	47504427	3	3	195	1	0	0	0	0	1	0	0	0	9460	565	20	4	1511	4	MDGA2	14	47504427	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	11911196	47504427	59845113	229	35979											
KCNH5	27133	broad.mit.edu	37	chr14	63175134	63175134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttctgccggaggcgctcctCctcctctttcttcacatcac	4	13	6	18	2	5	0	2	0	3	0	8	1	8	1	4	2	1	1	4	2	0	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:63175134C>T	uc001xfx.2	-	11	2110	c.2059G>A	c.(2059-2061)GAG>AAG	p.E687K	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	687	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		AGGCGCTCCTCCTCCTCTTTC	0.493													16	68					0	0	0	0	T	63175134	T	T	63175134	3	4	195	1	0	0	0	0	1	0	0	0	8074	864	30	2	911	2	KCNH5	14	63175134	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	15670707	63175134	44174406	230	35980											
EXD2	55218	broad.mit.edu	37	chr14	69701456	69701456	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcccagatttcagtggctCtctttcttcatcttcttgga	6	17	7	11	0	6	1	2	0	4	1	7	2	6	2	1	2	1	1	1	2	0	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:69701456C>T	uc001xkt.2	+	7	1041	c.382C>T	c.(382-384)CTC>TTC	p.L128F	EXD2_uc001xku.2_Intron|EXD2_uc001xkv.2_Missense_Mutation_p.L253F|EXD2_uc001xkw.2_Missense_Mutation_p.L128F|EXD2_uc010aqt.2_Missense_Mutation_p.L253F|EXD2_uc010tte.1_Missense_Mutation_p.L253F|EXD2_uc001xky.2_Missense_Mutation_p.L128F	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	128					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						TTCAGTGGCTCTCTTTCTTCA	0.433													9	26					0	0	0	0	T	69701456	T	T	69701456	3	4	195	1	0	0	0	0	1	0	0	0	5322	913	32	2	392	2	EXD2	14	69701456	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	6526322	69701456	37648084	231	35981											
C14orf169	79697	broad.mit.edu	37	chr14	73959074	73959074	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaagaaaatgtggagtttcgGaggggtctgccccgagactt	10	9	15	7	2	1	2	0	0	1	2	2	6	1	4	2	4	1	1	2	4	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:73959074G>C	uc001xok.1	+	3	1432	c.1353G>C	c.(1351-1353)CGG>CGC	p.R451R	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	451					negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)		TGGAGTTTCGGAGGGGTCTGC	0.547													13	45					0	0	0	0	C	73959074	C	C	73959074	2	2	195	1	0	0	0	0	0	0	0	1	1764	1174	41	2		2	C14orf169	14	73959074	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	4257618	73959074	33390466	232	35982											
SEL1L	6400	broad.mit.edu	37	chr14	81972553	81972553	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaaagggaagtggcagggctCcccatgtgctgtgccttcaa	10	8	13	10	0	1	0	1	0	0	0	2	1	2	1	3	3	2	3	3	3	4	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:81972553C>T	uc010tvv.1	-	4	490	c.373G>A	c.(373-375)GAG>AAG	p.E125K	SEL1L_uc001xvo.3_Missense_Mutation_p.E125K	NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	125	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Fibronectin type-II.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		TGGCAGGGCTCCCCATGTGCT	0.438													12	39					0	0	0	0	T	81972553	T	T	81972553	3	4	195	1	0	0	0	0	1	0	0	0	14075	864	30	2	2083	2	SEL1L	14	81972553	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	8013479	81972553	25376987	233	35983											
SLC24A4	123041	broad.mit.edu	37	chr14	92959967	92959967	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccgatgtgccgggaagacGattagcgctgagtcgcggcc	7	7	16	11	6	0	2	0	1	0	1	1	5	0	3	3	2	3	1	3	2	2	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:92959967G>A	uc001yak.2	+	17	1837	c.1813G>A	c.(1813-1815)GAT>AAT	p.D605N	SLC24A4_uc001yai.2_Missense_Mutation_p.D558N|SLC24A4_uc010twm.1_Missense_Mutation_p.D603N|SLC24A4_uc001yaj.2_Missense_Mutation_p.D586N|SLC24A4_uc010auj.2_3'UTR|SLC24A4_uc010twn.1_Missense_Mutation_p.D378N|SLC24A4_uc001yan.2_Missense_Mutation_p.D316N	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	622	Extracellular (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CCGGGAAGACGATTAGCGCTG	0.547													4	20					0	0	0	0	A	92959967	A	A	92959967	3	1	195	1	0	0	0	0	1	0	0	0	14532	1058	37	1	1879	1	SLC24A4	14	92959967	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	10987414	92959967	14389573	234	35984											
FAM181A	90050	broad.mit.edu	37	chr14	94395169	94395169	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttggagcccctgggacctGagactaccctggtgtccatg	6	9	13	13	0	0	1	0	1	0	1	1	4	1	3	5	3	2	1	5	3	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:94395169G>A	uc001ybz.1	+	3	1031	c.724G>A	c.(724-726)GAG>AAG	p.E242K	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Missense_Mutation_p.E180K|FAM181A_uc001yca.1_Missense_Mutation_p.E180K	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	242											0						CCTGGGACCTGAGACTACCCT	0.622													4	33					0	0	0	0	A	94395169	A	A	94395169	3	1	195	1	0	0	0	0	1	0	0	0	5536	1291	45	2	730	2	FAM181A	14	94395169	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1435202	94395169	12954371	235	35985											
DDX24	57062	broad.mit.edu	37	chr14	94521392	94521392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggaacagtgggatatcctCatctttcttgagcgttttgt	7	15	12	7	1	3	1	1	1	2	0	4	3	4	3	1	3	2	1	1	3	2	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:94521392C>T	uc001ycj.2	-	7	2227	c.2128G>A	c.(2128-2130)GAG>AAG	p.E710K	DDX24_uc010twq.1_Missense_Mutation_p.E667K|DDX24_uc010twr.1_Missense_Mutation_p.E460K	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	710	Helicase C-terminal.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		GGGATATCCTCATCTTTCTTG	0.463													32	149					0	0	0	0	T	94521392	T	T	94521392	3	4	195	1	0	0	0	0	1	0	0	0	4368	835	29	2	463	2	DDX24	14	94521392	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	126223	94521392	12828148	236	35986											
IFI27L1	122509	broad.mit.edu	37	chr14	94567115	94567115	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtagcagctgtggtcggagGaggtgagtctctatgggaag	8	10	18	5	1	1	1	0	1	1	0	3	4	1	4	0	5	2	3	0	5	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:94567115G>C	uc001ycl.2	+	3	267	c.59G>C	c.(58-60)GGA>GCA	p.G20A	IFI27L1_uc001yck.2_Missense_Mutation_p.G20A	NM_206949	NP_996832	Q96BM0	I27L1_HUMAN	interferon, alpha-inducible protein 27-like 1	20	Helical; (Potential).					integral to membrane					0						GTGGTCGGAGGAGGTGAGTCT	0.507													14	62					0	0	0	0	C	94567115	C	C	94567115	3	2	195	1	0	0	0	0	1	0	0	0	7552	1174	41	2	65	2	IFI27L1	14	94567115	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	45723	94567115	12782425	237	35987											
ATG2B	55102	broad.mit.edu	37	chr14	96757161	96757161	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaaactcacctaattgtacTagtgaatgcataggtccaac	15	10	7	9	0	1	1	1	1	0	0	2	2	2	1	2	1	4	2	2	1	8	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:96757161T>C	uc001yfi.2	-	39	6056	c.5691A>G	c.(5689-5691)CTA>CTG	p.L1897L		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1897										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CTAATTGTACTAGTGAATGCA	0.284													26	66					0	0	0	0	C	96757161	C	C	96757161	2	2	195	1	0	0	0	0	0	0	0	1	1096	1509	53	5		5	ATG2B	14	96757161	Silent	SNP	T	TCGA-CV-6936-01A-11D-1912-08	2190046	96757161	10592379	238	35988											
AKT1	207	broad.mit.edu	37	chr14	105246455	105246455	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagttgttgaggggagcctCacgttggtccacatcctgcg	7	10	14	10	2	1	1	1	1	0	0	3	3	3	2	3	3	2	3	3	3	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr14:105246455C>T	uc001ypk.2	-	3	699	c.145G>A	c.(145-147)GAG>AAG	p.E49K	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Missense_Mutation_p.E49K|AKT1_uc010axa.2_Missense_Mutation_p.E49K|AKT1_uc001ypm.2_Missense_Mutation_p.E49K|AKT1_uc001ypn.2_Missense_Mutation_p.E49K|AKT1_uc010tyk.1_5'Flank	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	49	PH.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity	p.E49K(1)		breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	AGGGGAGCCTCACGTTGGTCC	0.587		1	Mis		breast|colorectal|ovarian|NSCLC								11	13					0	0	0	0	T	105246455	T	T	105246455	3	4	195	1	0	0	0	0	1	0	0	0	478	835	29	2	1345	2	AKT1	14	105246455	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	8489294	105246455	2103085	239	35989											
ATP10A	57194	broad.mit.edu	37	chr15	25963462	25963462	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cactctggtggctgccgatgCtgccgcgctgggacaccgag	5	7	15	14	4	1	0	0	0	1	0	1	3	1	1	3	3	3	3	3	3	0	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr15:25963462C>A	uc010ayu.2	-	8	1554	c.1448G>T	c.(1447-1449)AGC>ATC	p.S483I		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	483	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCTGCCGATGCTGCCGCGCTG	0.711													11	8					6.40141e-05	0.000117086	1	0	A	25963462	A	A	25963462	3	1	195	1	0	0	0	0	1	0	0	0	1118	797	28	4	3107	4	ATP10A	15	25963462	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08		25963462	76567930	240	35990											
MYO5A	4644	broad.mit.edu	37	chr15	52656782	52656782	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatctcttccttgaggtcaTcatatctttcttccaggcga	7	16	6	12	1	6	1	3	1	3	0	9	2	8	1	2	2	0	0	2	2	1	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr15:52656782T>A	uc002aby.2	-	24	3522	c.3278A>T	c.(3277-3279)GAT>GTT	p.D1093V	MYO5A_uc002abx.3_Missense_Mutation_p.D1093V	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1093	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTTGAGGTCATCATATCTTTC	0.284													25	54					0	0	0	0	A	52656782	A	A	52656782	3	1	195	1	0	0	0	0	1	0	0	0	10131	1435	50	5	2361	5	MYO5A	15	52656782	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	26693320	52656782	49874610	241	35991											
TLN2	83660	broad.mit.edu	37	chr15	63128147	63128147	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcggccaatgcctccgttCagggacacgccagcgaggag	9	4	15	13	4	1	0	1	0	0	0	2	3	2	2	4	4	2	1	4	4	1	1	rs140723056	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr15:63128147C>G	uc002alb.3	+	54	7249	c.7249C>G	c.(7249-7251)CAG>GAG	p.Q2417E	TLN2_uc002alc.3_Missense_Mutation_p.Q810E|TLN2_uc010uic.1_Missense_Mutation_p.Q18E|uc002ale.1_5'Flank	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	2417	I/LWEQ.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TGCCTCCGTTCAGGGACACGC	0.647													5	37					0	0	0	0	G	63128147	G	G	63128147	3	3	195	1	0	0	0	0	1	0	0	0	16014	827	29	2	7463	2	TLN2	15	63128147	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	10471365	63128147	39403245	242	35992											
CALML4	91860	broad.mit.edu	37	chr15	68489825	68489825	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactcgtgagttttgaccgcAggtcggacgccatgacgtaa	9	9	13	10	5	0	3	0	3	0	0	2	5	0	4	2	2	0	3	2	2	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr15:68489825A>T	uc002arb.2	-	4	1180	c.446T>A	c.(445-447)CTG>CAG	p.L149Q	CALML4_uc002arc.2_Missense_Mutation_p.L102Q|CALML4_uc002ard.2_RNA|CALML4_uc002are.2_RNA|CALML4_uc010bhz.2_Intron	NM_033429	NP_219501	Q96GE6	CALL4_HUMAN	calmodulin-like 4 isoform 1	149	EF-hand 3.						calcium ion binding				0						TTTTGACCGCAGGTCGGACGC	0.498													21	71					0	0	0	0	T	68489825	T	T	68489825	3	4	195	1	0	0	0	0	1	0	0	0	2600	188	7	5	152	5	CALML4	15	68489825	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	5361678	68489825	34041567	243	35993											
ERCC4	2072	broad.mit.edu	37	chr16	14020442	14020442	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttggtgtatagagcccacaGaataatcgagtcttgtcaag	12	11	10	8	1	2	2	1	0	1	2	3	3	2	2	1	1	1	1	1	1	5	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:14020442G>A	uc002dce.2	+	3	422	c.413G>A	c.(412-414)AGA>AAA	p.R138K	ERCC4_uc010bva.2_Missense_Mutation_p.R138K	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	138					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						AGAGCCCACAGAATAATCGAG	0.353			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				6	98					0	0	0	0	A	14020442	A	A	14020442	3	1	195	1	0	0	0	0	1	0	0	0	5239	942	33	2	423	2	ERCC4	16	14020442	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08		14020442	76334311	244	35994											
C16orf46	123775	broad.mit.edu	37	chr16	81087678	81087678	+	Nonstop_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgaaactgatccctctcctActttatcttctttttcctgt	6	19	4	12	0	3	2	0	2	3	0	6	2	5	2	3	0	2	0	3	0	3	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:81087678A>G	uc010chf.2	-	4	1335	c.1165T>C	c.(1165-1167)TAG>CAG	p.*389Q		NM_001100873	NP_001094343	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 1	389											0						TCCCTCTCCTACTTTATCTTC	0.408													16	38					0	0	0	0	G	81087678	G	G	81087678	4	3	195	1	0	0	0	0	0	0	0	0	1821	404	14	5	5	5	C16orf46	16	81087678	Nonstop_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	67067236	81087678	9267075	245	35995											
MBTPS1	8720	broad.mit.edu	37	chr16	84108251	84108251	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgccgttgaggatggtgacaTtaacaactgtcggcattcct	9	12	11	9	2	0	2	0	2	0	0	2	3	1	3	2	3	3	2	2	3	2	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:84108251T>A	uc002fhi.2	-	12	2046	c.1544A>T	c.(1543-1545)AAT>ATT	p.N515I	MBTPS1_uc002fhh.2_Missense_Mutation_p.N19I	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	515	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						GATGGTGACATTAACAACTGT	0.478													16	27					0	0	0	0	A	84108251	A	A	84108251	3	1	195	1	0	0	0	0	1	0	0	0	9414	1493	52	5	1662	5	MBTPS1	16	84108251	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	3020573	84108251	6246502	246	35996											
JPH3	57338	broad.mit.edu	37	chr16	87678544	87678544	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaagaacctcatccccctgCgggccagcaagatccgcgag	10	4	11	16	3	1	2	1	0	0	2	3	3	3	2	5	1	3	2	5	1	3	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:87678544C>T	uc002fkd.2	+	2	1317	c.1063C>T	c.(1063-1065)CGG>TGG	p.R355W	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	355	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CATCCCCCTGCGGGCCAGCAA	0.652													10	24					0	0	0	0	T	87678544	T	T	87678544	3	4	195	1	0	0	0	0	1	0	0	0	8001	759	27	1	1069	1	JPH3	16	87678544	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	3570293	87678544	2676209	247	35997											
ZC3H18	124245	broad.mit.edu	37	chr16	88664701	88664701	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctaatggtgccccgcctctCggacctcacccgctgatgcc	5	8	9	19	3	2	1	1	1	1	0	3	2	2	2	7	2	2	1	7	2	1	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr16:88664701C>T	uc002fky.2	+	4	1004	c.804C>T	c.(802-804)CTC>CTT	p.L268L	ZC3H18_uc010voy.1_Silent_p.L151L|ZC3H18_uc010voz.1_Silent_p.L292L	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	268	Pro-rich.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CCCCGCCTCTCGGACCTCACC	0.537													6	62					0	0	0	0	T	88664701	T	T	88664701	2	4	195	1	0	0	0	0	0	0	0	1	17635	871	31	1		1	ZC3H18	16	88664701	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	986157	88664701	1690052	248	35998											
RPA1	6117	broad.mit.edu	37	chr17	1783840	1783840	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgtttcttttacaggctGataaatttgatggttctaga	9	18	10	4	0	2	3	0	2	2	1	2	3	2	3	0	3	1	3	0	3	4	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:1783840G>A	uc002fto.2	+	12	1211	c.1096G>A	c.(1096-1098)GAT>AAT	p.D366N		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	366					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TTTACAGGCTGATAAATTTGA	0.428								NER					16	33					0	0	0	0	A	1783840	A	A	1783840	3	1	195	1	0	0	0	0	1	0	0	0	13601	1290	45	2	1142	2	RPA1	17	1783840	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08		1783840	79411370	249	35999											
NEURL4	84461	broad.mit.edu	37	chr17	7230539	7230539	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgggcctgcgctggggaCaccatgaaggctggggacca	7	4	18	12	2	0	1	0	1	0	0	0	3	0	3	4	7	1	2	4	7	1	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7230539C>T	uc002gga.1	-	3	745	c.738G>A	c.(736-738)GTG>GTA	p.V246V	NEURL4_uc002ggb.1_Silent_p.V246V|NEURL4_uc002ggc.1_5'Flank	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	246							protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCGCTGGGGACACCATGAAGG	0.627													8	16					0	0	0	0	T	7230539	T	T	7230539	2	4	195	1	0	0	0	0	0	0	0	1	10401	465	17	4		4	NEURL4	17	7230539	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	5446699	7230539	73964671	250	36000											
POLR2A	5430	broad.mit.edu	37	chr17	7399540	7399540	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcccacaggaaacatgacaGagtgtcctggccactttggc	10	8	11	12	0	0	2	0	1	0	1	2	3	2	3	3	3	1	0	3	3	1	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7399540G>C	uc002ghf.3	+	3	472	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	POLR2A_uc002ghe.2_Missense_Mutation_p.E80Q	NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	80					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				AAACATGACAGAGTGTCCTGG	0.537													6	48					0	0	0	0	C	7399540	C	C	7399540	3	2	195	1	0	0	0	0	1	0	0	0	12269	943	33	2	248	2	POLR2A	17	7399540	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	169001	7399540	73795670	251	36001											
TP53	7157	broad.mit.edu	37	chr17	7578413	7578413	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtgggggcagcgcctcaCaacctccgtcatgtgctgtg	6	9	14	12	2	2	0	2	0	0	0	3	0	3	0	3	3	3	2	3	3	1	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7578413C>A	uc002gim.2	-	5	711	c.517G>T	c.(517-519)GTG>TTG	p.V173L	TP53_uc002gig.1_Missense_Mutation_p.V173L|TP53_uc002gih.2_Missense_Mutation_p.V173L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V41L|TP53_uc010cng.1_Missense_Mutation_p.V41L|TP53_uc002gii.1_Missense_Mutation_p.V41L|TP53_uc010cnh.1_Missense_Mutation_p.V173L|TP53_uc010cni.1_Missense_Mutation_p.V173L|TP53_uc002gij.2_Missense_Mutation_p.V173L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V80L|TP53_uc002gio.2_Missense_Mutation_p.V41L|TP53_uc010vug.1_Missense_Mutation_p.V134L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(54)|p.V173M(40)|p.V173A(8)|p.V173V(8)|p.0?(7)|p.V173G(6)|p.V173fs*1(4)|p.V80L(2)|p.V173fs*59(2)|p.V41L(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.V173E(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.V80M(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.V41M(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	22					9.65021e-13	1.84938e-12	1	0	A	7578413	A	A	7578413	3	1	195	1	0	0	0	0	1	0	0	0	16448	478	17	4	781	4	TP53	17	7578413	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	178873	7578413	73616797	252	36002											
DNAH2	146754	broad.mit.edu	37	chr17	7637808	7637808	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccatgatccactggaccCggcagataaaggagatgctc	11	7	10	13	1	0	3	0	1	0	2	3	5	2	4	4	3	1	2	4	3	2	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7637808C>T	uc002giu.1	+	6	774	c.760C>T	c.(760-762)CGG>TGG	p.R254W	DNAH2_uc002git.2_Missense_Mutation_p.R254W|DNAH2_uc010vuk.1_Missense_Mutation_p.R254W	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	254	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCACTGGACCCGGCAGATAAA	0.537													9	38					0	0	0	0	T	7637808	T	T	7637808	3	4	195	1	0	0	0	0	1	0	0	0	4624	643	23	1	782	1	DNAH2	17	7637808	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	59395	7637808	73557402	253	36003											
KDM6B	23135	broad.mit.edu	37	chr17	7752018	7752018	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagcccggccagcctgctCaaatccttggcctccgtgct	5	8	9	19	2	1	0	1	0	0	0	3	0	3	0	7	2	4	2	7	2	1	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7752018C>G	uc002giw.1	+	11	2788	c.2412C>G	c.(2410-2412)CTC>CTG	p.L804L	KDM6B_uc002gix.2_Silent_p.L106L	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	804	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCAGCCTGCTCAAATCCTTGG	0.363													6	52					0	0	0	0	G	7752018	G	G	7752018	2	3	195	1	0	0	0	0	0	0	0	1	8177	813	29	2		2	KDM6B	17	7752018	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	114210	7752018	73443192	254	36004											
CHD3	1107	broad.mit.edu	37	chr17	7794330	7794330	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtggagcatgtgttctctGaggaggattaccacacgctc	9	11	12	9	1	1	1	0	1	1	0	3	4	1	4	1	3	2	3	1	3	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:7794330G>A	uc002gje.2	+	4	607	c.457G>A	c.(457-459)GAG>AAG	p.E153K	CHD3_uc002gjd.2_Missense_Mutation_p.E212K|CHD3_uc002gjf.2_Missense_Mutation_p.E153K|CHD3_uc002gjg.1_5'UTR	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	153					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TGTGTTCTCTGAGGAGGATTA	0.512													28	70					0	0	0	0	A	7794330	A	A	7794330	3	1	195	1	0	0	0	0	1	0	0	0	3341	1291	45	2	752	2	CHD3	17	7794330	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	42312	7794330	73400880	255	36005											
MYH8	4626	broad.mit.edu	37	chr17	10309390	10309390	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcttctgatattctaccctCattaggaatcccctacagac	11	13	4	13	0	4	2	1	1	3	1	5	3	5	3	3	1	2	0	3	1	5	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:10309390C>G	uc002gmm.2	-	21	2495	c.2400G>C	c.(2398-2400)ATG>ATC	p.M800I	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	800	IQ.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ATTCTACCCTCATTAGGAATC	0.373									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				8	66					0	0	0	0	G	10309390	G	G	10309390	3	3	195	1	0	0	0	0	1	0	0	0	10094	826	29	2	3493	2	MYH8	17	10309390	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	2515060	10309390	70885820	256	36006											
DNAH9	1770	broad.mit.edu	37	chr17	11607549	11607549	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acctgtactcagatctggtgGacaacagaagtgggcatggc	11	8	13	9	0	2	2	1	0	1	2	2	3	2	3	1	4	2	2	1	4	3	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:11607549G>A	uc002gne.2	+	25	5249	c.5181G>A	c.(5179-5181)TGG>TGA	p.W1727*	DNAH9_uc010coo.2_Nonsense_Mutation_p.W1021*	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1727	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGATCTGGTGGACAACAGAAG	0.507													5	112					0	0	0	0	A	11607549	A	A	11607549	4	1	195	1	0	0	0	0	0	1	0	0	4630	1183	41	2	5279	2	DNAH9	17	11607549	Nonsense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1298159	11607549	69587661	257	36007											
PRPSAP2	5636	broad.mit.edu	37	chr17	18775924	18775924	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacaaattcaagagtctgtGaggggaaaagatgttttcat	14	12	11	4	0	3	3	2	1	1	2	3	4	3	4	0	2	1	2	0	2	5	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:18775924G>T	uc002gup.1	+	5	412	c.201G>T	c.(199-201)GTG>GTT	p.V67V	PRPSAP2_uc002guo.1_5'UTR|PRPSAP2_uc010vyi.1_Intron|PRPSAP2_uc010vyj.1_5'UTR|PRPSAP2_uc010vyk.1_Silent_p.V55V	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	67					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1						AAGAGTCTGTGAGGGGAAAAG	0.348													41	168					1.57019e-19	3.06403e-19	1	0	T	18775924	T	T	18775924	2	4	195	1	0	0	0	0	0	0	0	1	12644	1277	45	2		2	PRPSAP2	17	18775924	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	7168375	18775924	62419286	258	36008											
KIAA0100	9703	broad.mit.edu	37	chr17	26965108	26965108	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcccagaggctggttatagCtaccctagagaagaagcaga	13	6	13	9	0	0	4	0	0	0	4	0	5	0	4	2	3	3	4	2	3	6	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:26965108C>G	uc002hbu.2	-	14	1616	c.1517G>C	c.(1516-1518)AGC>ACC	p.S506T		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	506						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CTGGTTATAGCTACCCTAGAG	0.498													12	54					0	0	0	0	G	26965108	G	G	26965108	3	3	195	1	0	0	0	0	1	0	0	0	8193	797	28	4	5294	4	KIAA0100	17	26965108	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	8189184	26965108	54230102	259	36009											
KRT27	342574	broad.mit.edu	37	chr17	38938473	38938473	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taggaggccaagcggtcgttGaggttctgcatggtcacctt	7	11	14	9	2	2	1	1	1	1	0	3	2	2	2	2	5	2	3	2	5	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:38938473G>C	uc002hvg.2	-	1	314	c.273C>G	c.(271-273)CTC>CTG	p.L91L		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	91	Rod.|Coil 1A.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				AGCGGTCGTTGAGGTTCTGCA	0.572													33	63					0	0	0	0	C	38938473	C	C	38938473	2	2	195	1	0	0	0	0	0	0	0	1	8503	1277	45	2		2	KRT27	17	38938473	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	11973365	38938473	42256737	260	36010											
DHX8	1659	broad.mit.edu	37	chr17	41585799	41585799	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatccctgggacctgatgttCcagagttaattatcctccca	10	12	7	12	0	0	2	0	1	0	1	4	3	4	3	5	1	0	2	5	1	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:41585799C>T	uc002idu.1	+	16	2486	c.2413C>T	c.(2413-2415)CCA>TCA	p.P805S	DHX8_uc010wif.1_Missense_Mutation_p.P714S|DHX8_uc010wig.1_Missense_Mutation_p.P805S	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	805	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ACCTGATGTTCCAGAGTTAAT	0.488													13	61					0	0	0	0	T	41585799	T	T	41585799	3	4	195	1	0	0	0	0	1	0	0	0	4537	855	30	2	2475	2	DHX8	17	41585799	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	2647326	41585799	39609411	261	36011											
ARHGAP27	201176	broad.mit.edu	37	chr17	43480174	43480174	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actcaggggtggaaaacttgGaaggctgcctctgtgggaga	10	8	16	7	0	2	1	1	0	1	1	2	4	2	3	1	6	2	1	1	6	3	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:43480174G>A	uc002iix.2	-	9	1075	c.626C>T	c.(625-627)TCC>TTC	p.S209F	ARHGAP27_uc010dak.2_Missense_Mutation_p.S182F|ARHGAP27_uc010wjl.1_Missense_Mutation_p.S328F	NM_199282	NP_954976	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27 isoform a	550	PH.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)					GGAAAACTTGGAAGGCTGCCT	0.572													19	38					0	0	0	0	A	43480174	A	A	43480174	3	1	195	1	0	0	0	0	1	0	0	0	876	1174	41	2	1056	2	ARHGAP27	17	43480174	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1894375	43480174	37715036	262	36012											
ABCA8	10351	broad.mit.edu	37	chr17	66890418	66890418	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aactgggaagcaattcaatcTtttggcattgcatgctaacg	12	12	9	8	1	2	0	1	0	1	0	2	1	2	1	0	2	5	4	0	2	5	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr17:66890418T>C	uc002jhp.2	-	21	2991	c.2812A>G	c.(2812-2814)AGA>GGA	p.R938G	ABCA8_uc002jhq.2_Missense_Mutation_p.R978G|ABCA8_uc010wqq.1_Missense_Mutation_p.R978G|ABCA8_uc010wqr.1_Missense_Mutation_p.R917G|ABCA8_uc002jhr.2_Missense_Mutation_p.R978G	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	938						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CAATTCAATCTTTTGGCATTG	0.313													7	14					0	0	0	0	C	66890418	C	C	66890418	3	2	195	1	0	0	0	0	1	0	0	0	38	1617	56	5	2005	5	ABCA8	17	66890418	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	23410244	66890418	14304792	263	36013											
NOL4	8715	broad.mit.edu	37	chr18	31523045	31523045	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacctgctgtctctccagaCgcatcctcttggcggcattt	5	13	9	14	2	2	1	0	0	2	1	5	1	4	1	3	2	2	4	3	2	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr18:31523045C>T	uc010dmi.2	-	9	1755	c.1526G>A	c.(1525-1527)CGT>CAT	p.R509H	NOL4_uc010xbs.1_Missense_Mutation_p.R224H|NOL4_uc002kxr.3_Missense_Mutation_p.R281H|NOL4_uc010xbt.1_Missense_Mutation_p.R435H|NOL4_uc010dmh.2_Missense_Mutation_p.R371H|NOL4_uc010xbu.1_Missense_Mutation_p.R445H|NOL4_uc002kxt.3_Intron|NOL4_uc010xbv.1_Missense_Mutation_p.R194H	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	509						nucleolus	RNA binding			ovary(3)	3						TCTCTCCAGACGCATCCTCTT	0.443													10	56					0	0	0	0	T	31523045	T	T	31523045	3	4	195	1	0	0	0	0	1	0	0	0	10578	536	19	1	402	1	NOL4	18	31523045	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08		31523045	46554203	264	36014											
DTNA	1837	broad.mit.edu	37	chr18	32428280	32428280	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgcttgagagttcaaaccGgcttgatgaagaacacaggc	13	8	11	9	1	1	4	1	3	0	2	1	5	1	4	1	2	3	3	1	2	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr18:32428280G>A	uc010dmn.1	+	13	1287	c.1286G>A	c.(1285-1287)CGG>CAG	p.R429Q	DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Missense_Mutation_p.R372Q|DTNA_uc002kxw.2_Missense_Mutation_p.R372Q|DTNA_uc010dmj.2_Missense_Mutation_p.R369Q|DTNA_uc002kxz.2_Missense_Mutation_p.R369Q|DTNA_uc002kxy.2_Missense_Mutation_p.R369Q|DTNA_uc010dml.2_Missense_Mutation_p.R369Q|DTNA_uc002kyb.3_Missense_Mutation_p.R426Q|DTNA_uc010dmm.2_Missense_Mutation_p.R429Q|DTNA_uc010xby.1_Missense_Mutation_p.R119Q|DTNA_uc010dmo.2_Missense_Mutation_p.R51Q|DTNA_uc002kyd.3_Missense_Mutation_p.R51Q|DTNA_uc010xbz.1_Missense_Mutation_p.R138Q|DTNA_uc010xca.1_Missense_Mutation_p.R81Q|DTNA_uc002kye.2_Missense_Mutation_p.R77Q	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	429	Syntrophin-binding region.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						AGTTCAAACCGGCTTGATGAA	0.448													20	24					0	0	0	0	A	32428280	A	A	32428280	3	1	195	1	0	0	0	0	1	0	0	0	4810	1116	39	1	1371	1	DTNA	18	32428280	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	905235	32428280	45648968	265	36015											
CDH19	28513	broad.mit.edu	37	chr18	64178908	64178908	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatctctatccactgcactGatagtctgaattacctaaaa	13	13	4	11	0	3	2	1	2	2	0	5	2	4	2	2	0	2	1	2	0	6	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr18:64178908G>A	uc002lkc.1	-	10	1611	c.1473C>T	c.(1471-1473)ATC>ATT	p.I491I	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Intron	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	491	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CCACTGCACTGATAGTCTGAA	0.318													20	32					0	0	0	0	A	64178908	A	A	64178908	2	1	195	1	0	0	0	0	0	0	0	1	3119	1280	45	2		2	CDH19	18	64178908	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	31750628	64178908	13898340	266	36016											
SHD	56961	broad.mit.edu	37	chr19	4282869	4282869	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccttccttctctccgcagctGgaagccgacactgagtattt	7	12	8	14	2	1	1	0	1	1	0	4	3	3	2	4	1	2	3	4	1	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:4282869G>A	uc002lzw.2	+	2	1763	c.300G>A	c.(298-300)CTG>CTA	p.L100L	SHD_uc010dtu.2_Silent_p.L100L	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	100											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCGCAGCTGGAAGCCGACA	0.572													32	54					0	0	0	0	A	4282869	A	A	4282869	2	1	195	1	0	0	0	0	0	0	0	1	14340	1335	47	4		4	SHD	19	4282869	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08		4282869	54846114	267	36017											
CD320	51293	broad.mit.edu	37	chr19	8367860	8367860	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccttccgggaggatctcattGgttcctgcaataagcccagg	8	10	11	12	1	1	0	1	0	1	0	4	2	3	2	4	4	2	2	4	4	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:8367860G>A	uc002mjj.1	-	4	572	c.507C>T	c.(505-507)ACC>ACT	p.T169T	CD320_uc002mjk.1_RNA|CD320_uc002mjl.1_Silent_p.T127T	NM_016579	NP_057663	Q9NPF0	CD320_HUMAN	8D6 antigen isoform 1 precursor	169	Extracellular (Potential).				regulation of cell growth	endoplasmic reticulum|integral to membrane	growth factor activity				0						GGATCTCATTGGTTCCTGCAA	0.607													4	15					0	0	0	0	A	8367860	A	A	8367860	2	1	195	1	0	0	0	0	0	0	0	1	3019	1335	47	4		4	CD320	19	8367860	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	4084991	8367860	50761123	268	36018											
ZNF266	10781	broad.mit.edu	37	chr19	9524534	9524534	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgaaggctttcccacaaTccttacatttatagggtttt	10	15	8	8	0	0	1	0	1	0	0	2	2	2	1	2	2	1	2	2	2	5	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:9524534T>G	uc002mll.2	-	4	1333	c.1067A>C	c.(1066-1068)GAT>GCT	p.D356A	ZNF266_uc002mlm.2_Missense_Mutation_p.D356A|ZNF266_uc002mln.2_Missense_Mutation_p.D356A|ZNF266_uc002mlo.2_Missense_Mutation_p.D356A|ZNF266_uc010dwp.2_Missense_Mutation_p.D356A|ZNF266_uc010dwq.2_Missense_Mutation_p.D356A	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	356	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTTCCCACAATCCTTACATTT	0.413													18	46					0	0	0	0	G	9524534	G	G	9524534	3	3	195	1	0	0	0	0	1	0	0	0	17872	1435	50	5	586	5	ZNF266	19	9524534	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	1156674	9524534	49604449	269	36019											
ZNF442	79973	broad.mit.edu	37	chr19	12461237	12461237	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttcgaaagcttgagtgatGagataacgctttcccacact	12	11	8	10	2	0	3	0	3	0	1	2	5	1	3	1	0	2	2	1	0	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:12461237G>C	uc002mtr.1	-	6	1773	c.1162C>G	c.(1162-1164)CAT>GAT	p.H388D	ZNF442_uc010xmk.1_Missense_Mutation_p.H319D	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	388	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						CTTGAGTGATGAGATAACGCT	0.428													9	168					0	0	0	0	C	12461237	C	C	12461237	3	2	195	1	0	0	0	0	1	0	0	0	17982	1290	45	2	725	2	ZNF442	19	12461237	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	2936703	12461237	46667746	270	36020											
MAST1	22983	broad.mit.edu	37	chr19	12969220	12969220	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgccgggggagaatgacttCgataccatcaagctcataag	12	7	11	11	3	2	2	2	1	0	1	3	4	2	2	3	2	2	1	3	2	4	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:12969220C>T	uc002mvm.2	+	11	1250	c.1122C>T	c.(1120-1122)TTC>TTT	p.F374F	MAST1_uc002mvk.2_Silent_p.F370F	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	374	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						AGAATGACTTCGATACCATCA	0.582													21	131					0	0	0	0	T	12969220	T	T	12969220	2	4	195	1	0	0	0	0	0	0	0	1	9377	883	31	1		1	MAST1	19	12969220	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	507983	12969220	46159763	271	36021											
ZNF708	7562	broad.mit.edu	37	chr19	21492100	21492100	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atattccagggctcttttccTtgctccagacaggtgatcag	8	13	9	11	0	2	2	1	1	1	1	5	2	5	2	3	2	1	2	3	2	1	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:21492100T>A	uc002npq.1	-	3	372	c.174A>T	c.(172-174)CAA>CAT	p.Q58H	ZNF708_uc002npr.1_Translation_Start_Site|ZNF708_uc010ecs.1_Translation_Start_Site	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	58	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						GCTCTTTTCCTTGCTCCAGAC	0.428													24	72					0	0	0	0	A	21492100	A	A	21492100	3	1	195	1	0	0	0	0	1	0	0	0	18179	1606	56	5	1525	5	ZNF708	19	21492100	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	8522880	21492100	37636883	272	36022											
ZNF493	284443	broad.mit.edu	37	chr19	21606747	21606747	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acataaaagaattcatactgGagagaaaccctacaaatgtg	19	8	7	7	0	1	2	1	0	0	2	1	4	1	3	1	1	3	0	1	1	7	4	rs143136118		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:21606747G>C	uc002npx.2	+	2	1182	c.902G>C	c.(901-903)GGA>GCA	p.G301A	ZNF493_uc002npw.2_Missense_Mutation_p.G429A|ZNF493_uc002npy.2_Missense_Mutation_p.G301A	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATTCATACTGGAGAGAAACCC	0.338													3	30					0	0	0	0	C	21606747	C	C	21606747	3	2	195	1	0	0	0	0	1	0	0	0	18011	1174	41	2	1363	2	ZNF493	19	21606747	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	114647	21606747	37522236	273	36023											
ZNF91	7644	broad.mit.edu	37	chr19	23542840	23542840	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattatcttatgttcagtaaGagttgaagatttcctaaaag	15	15	7	4	0	2	3	1	1	1	2	3	3	3	3	1	0	0	3	1	0	7	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:23542840G>A	uc002nre.2	-	4	3054	c.2941C>T	c.(2941-2943)CTT>TTT	p.L981F	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.L949F	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	981	C2H2-type 30.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TGTTCAGTAAGAGTTGAAGAT	0.378													5	48					0	0	0	0	A	23542840	A	A	23542840	3	1	195	1	0	0	0	0	1	0	0	0	18267	942	33	2	638	2	ZNF91	19	23542840	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1936093	23542840	35586143	274	36024											
KIRREL2	84063	broad.mit.edu	37	chr19	36355599	36355599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctggttctggaggagaaagGgactctggagaccaaggtga	11	8	16	6	0	3	3	0	1	3	2	3	7	3	5	1	6	0	1	1	6	2	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:36355599G>A	uc002ocb.3	+	14	1987	c.1775G>A	c.(1774-1776)GGG>GAG	p.G592E	KIRREL2_uc002obz.3_Missense_Mutation_p.G592E|KIRREL2_uc002oca.3_Missense_Mutation_p.G542E|KIRREL2_uc002occ.3_Missense_Mutation_p.G539E|KIRREL2_uc002ocd.3_Missense_Mutation_p.G554E	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	592	Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGGAGAAAGGGACTCTGGAG	0.597													26	16					0	0	0	0	A	36355599	A	A	36355599	3	1	195	1	0	0	0	0	1	0	0	0	8364	1232	43	4	1829	4	KIRREL2	19	36355599	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	12812759	36355599	22773384	275	36025											
PSG5	5673	broad.mit.edu	37	chr19	43688992	43688992	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcctatcacctcgctttatGatgtgtaaggtgtaggatcc	8	14	10	9	1	1	1	1	1	0	0	4	2	3	2	3	2	0	3	3	2	4	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:43688992G>C	uc002ovu.2	-	2	503	c.372C>G	c.(370-372)ATC>ATG	p.I124M	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.I52M|PSG5_uc002ovx.2_Missense_Mutation_p.I124M|PSG5_uc002ovv.2_Missense_Mutation_p.I124M|PSG5_uc002ovw.2_Missense_Mutation_p.I124M	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	124	Ig-like V-type.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				CTCGCTTTATGATGTGTAAGG	0.493													114	238					0	0	0	0	C	43688992	C	C	43688992	3	2	195	1	0	0	0	0	1	0	0	0	12720	1280	45	2	651	2	PSG5	19	43688992	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	7333393	43688992	15439991	276	36026											
ZNF233	353355	broad.mit.edu	37	chr19	44777511	44777511	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtacacaaaagagagaaagCttttagccacaataattgtg	18	9	8	6	0	0	2	0	0	0	2	0	3	0	2	1	0	3	2	1	0	7	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:44777511C>A	uc002oyz.1	+	5	825	c.698C>A	c.(697-699)GCT>GAT	p.A233D	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.A48D	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				AGAGAGAAAGCTTTTAGCCAC	0.368													9	26					0.000274275	0.000498823	1	0	A	44777511	A	A	44777511	3	1	195	1	0	0	0	0	1	0	0	0	17853	797	28	4	712	4	ZNF233	19	44777511	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	1088519	44777511	14351472	277	36027											
SFRS16	11129	broad.mit.edu	37	chr19	45563652	45563652	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccacctctataggatgcTccggaaagacaaggaggagg	13	5	12	11	1	1	1	0	0	1	1	2	5	2	5	3	5	1	1	3	5	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:45563652T>A	uc002pak.2	+	9	814	c.716T>A	c.(715-717)CTC>CAC	p.L239H	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Missense_Mutation_p.L177H|SFRS16_uc002pam.2_Missense_Mutation_p.L239H|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	239					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TATAGGATGCTCCGGAAAGAC	0.572													8	28					0	0	0	0	A	45563652	A	A	45563652	3	1	195	1	0	0	0	0	1	0	0	0	14237	1551	54	5	746	5	SFRS16	19	45563652	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	786141	45563652	13565331	278	36028											
SYMPK	8189	broad.mit.edu	37	chr19	46328447	46328447	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accggctgctcaatgaccctCagcaccgtccgcttgatgtc	7	9	9	16	3	2	2	2	2	0	0	4	2	3	2	4	1	2	4	4	1	1	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:46328447C>G	uc002pdn.2	-	18	2717	c.2472G>C	c.(2470-2472)CTG>CTC	p.L824L	SYMPK_uc002pdo.1_Silent_p.L824L|SYMPK_uc002pdp.1_Silent_p.L824L	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	824					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CAATGACCCTCAGCACCGTCC	0.647													5	66					0	0	0	0	G	46328447	G	G	46328447	2	3	195	1	0	0	0	0	0	0	0	1	15505	813	29	2		2	SYMPK	19	46328447	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	764795	46328447	12800536	279	36029											
NUP62	23636	broad.mit.edu	37	chr19	50412910	50412910	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccggtggaaggggtacttGtggctggttggaagggagcc	6	8	21	6	1	0	0	0	0	0	0	0	3	0	3	2	9	2	3	2	9	3	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:50412910G>C	uc002pqx.2	-	2	259	c.155C>G	c.(154-156)ACA>AGA	p.T52R	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.T52R|NUP62_uc002pqz.2_Missense_Mutation_p.T52R|NUP62_uc002pra.2_Missense_Mutation_p.T52R|NUP62_uc002prb.2_Missense_Mutation_p.T52R|NUP62_uc002prc.2_Missense_Mutation_p.T52R	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	52	15 X 9 AA approximate repeats.|Thr-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		AGGGGTACTTGTGGCTGGTTG	0.567													7	134					0	0	0	0	C	50412910	C	C	50412910	3	2	195	1	0	0	0	0	1	0	0	0	10822	1377	48	4	1417	4	NUP62	19	50412910	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	4084463	50412910	8716073	280	36030											
SIGLEC5	8778	broad.mit.edu	37	chr19	52115506	52115506	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttgcttgtcttgatctccGagtactccgtggtgcttggg	4	15	12	10	2	2	1	0	1	2	0	4	2	3	1	2	2	3	3	2	2	1	5			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr19:52115506G>A	uc002pxe.2	-	9	1773	c.1634C>T	c.(1633-1635)TCG>TTG	p.S545L		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	545	SLAM-like motif.|Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CTTGATCTCCGAGTACTCCGT	0.537													16	80					0	0	0	0	A	52115506	A	A	52115506	3	1	195	1	0	0	0	0	1	0	0	0	14376	1059	37	1	25	1	SIGLEC5	19	52115506	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1702596	52115506	7013477	281	36031											
TGM6	343641	broad.mit.edu	37	chr20	2375175	2375175	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaggagtacccctgccctGagctggtggttcgcaggggc	5	7	15	14	1	0	1	0	1	0	0	1	2	0	2	4	5	3	4	4	5	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:2375175G>A	uc002wfy.1	+	2	146	c.85G>A	c.(85-87)GAG>AAG	p.E29K	TGM6_uc010gal.1_Missense_Mutation_p.E29K	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	29					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CCCCTGCCCTGAGCTGGTGGT	0.627													4	30					0	0	0	0	A	2375175	A	A	2375175	3	1	195	1	0	0	0	0	1	0	0	0	15900	1291	45	2	91	2	TGM6	20	2375175	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08		2375175	60650345	282	36032											
TM9SF4	9777	broad.mit.edu	37	chr20	30729430	30729430	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acagtggagcagagccgactCgtggccgagcggatcacaga	11	4	15	11	4	1	2	1	0	0	2	2	6	1	4	2	3	3	1	2	3	0	0	rs117023270	by1000genomes	TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:30729430C>T	uc002wxj.2	+	4	595	c.360C>T	c.(358-360)CTC>CTT	p.L120L	TM9SF4_uc010ztr.1_Silent_p.L46L|TM9SF4_uc010zts.1_Silent_p.L27L|TM9SF4_uc002wxk.2_Silent_p.L103L|TM9SF4_uc010gdz.2_Silent_p.L27L	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	120						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGAGCCGACTCGTGGCCGAGC	0.577													9	137					0	0	0	0	T	30729430	T	T	30729430	2	4	195	1	0	0	0	0	0	0	0	1	16046	871	31	1		1	TM9SF4	20	30729430	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	28354255	30729430	32296090	283	36033											
NCOA6	23054	broad.mit.edu	37	chr20	33329653	33329653	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctcttcgacactgggaagTttgttaggatccgaaggctg	8	13	12	8	2	1	0	0	0	1	0	4	4	2	2	1	3	0	3	1	3	3	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:33329653T>C	uc002xav.2	-	12	6978	c.4407A>G	c.(4405-4407)AAA>AAG	p.K1469K	NCOA6_uc002xaw.2_Silent_p.K1469K	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1469					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CACTGGGAAGTTTGTTAGGAT	0.448													31	140					0	0	0	0	C	33329653	C	C	33329653	2	2	195	1	0	0	0	0	0	0	0	1	10287	1722	60	5		5	NCOA6	20	33329653	Silent	SNP	T	TCGA-CV-6936-01A-11D-1912-08	2600223	33329653	29695867	284	36034											
KIAA1755	85449	broad.mit.edu	37	chr20	36850870	36850870	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cctgacatcagggctgaagtCcagcctgctggcatcatgct	8	9	11	13	0	2	2	2	2	0	0	3	2	3	2	3	2	3	4	3	2	1	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:36850870C>G	uc002xhy.1	-	10	2670	c.2398G>C	c.(2398-2400)GAC>CAC	p.D800H	KIAA1755_uc002xhx.1_Missense_Mutation_p.D78H	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	800										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GGGCTGAAGTCCAGCCTGCTG	0.642											OREG0025921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	95					0	0	0	0	G	36850870	G	G	36850870	3	3	195	1	0	0	0	0	1	0	0	0	8296	855	30	2	1224	2	KIAA1755	20	36850870	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	3521217	36850870	26174650	285	36035											
PLCG1	5335	broad.mit.edu	37	chr20	39791883	39791883	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgccgagtgtcccttcctGagttccagcagttccttctt	4	16	8	13	1	1	1	0	1	1	0	5	2	5	1	5	0	2	3	5	0	0	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:39791883G>C	uc002xjp.1	+	8	878	c.757G>C	c.(757-759)GAG>CAG	p.E253Q	PLCG1_uc002xjo.1_Missense_Mutation_p.E253Q|PLCG1_uc010zwe.1_5'Flank|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	253					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GTCCCTTCCTGAGTTCCAGCA	0.607													20	111					0	0	0	0	C	39791883	C	C	39791883	3	2	195	1	0	0	0	0	1	0	0	0	12090	1291	45	2	787	2	PLCG1	20	39791883	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	2941013	39791883	23233637	286	36036											
MC3R	4159	broad.mit.edu	37	chr20	54823685	54823686	+	5'Flank	DEL	TC	-	-																															tctttctctctgtgtgtatgTctctctctctctctgtctct																										TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:54823685_54823686delTC	uc002xxb.2	+							NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor						activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			tgtgtgtatgtctctctctctc	0.208													---	---	---								-	54823686	-	-	54823685	6	5	195	0	1	1	0	1	0	0	0	0	9418	1682	58	0		0	MC3R	20	54823685	5'Flank	DEL	TC	TCGA-CV-6936-01A-11D-1912-08	15031802	54823685	8201835	287	36037											
SLCO4A1	28231	broad.mit.edu	37	chr20	61292481	61292481	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgaaggacagcagccgtgggGaggcgagcaacccggacttt	10	5	16	10	3	0	1	0	1	0	0	0	5	0	4	2	5	4	2	2	5	2	1	rs138628669		TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:61292481G>A	uc002ydb.1	+	5	1280	c.1075G>A	c.(1075-1077)GAG>AAG	p.E359K	SLCO4A1_uc002ydc.1_RNA	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	359	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CAGCCGTGGGGAGGCGAGCAA	0.617													30	67					0	0	0	0	A	61292481	A	A	61292481	3	1	195	1	0	0	0	0	1	0	0	0	14793	1175	41	2	1089	2	SLCO4A1	20	61292481	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	6468796	61292481	1733039	288	36038											
DIDO1	11083	broad.mit.edu	37	chr20	61541176	61541176	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttgtacaatcggtgccatCagcatctccaggtctccatt	9	12	7	13	1	3	0	1	0	2	0	6	0	3	0	3	2	3	2	3	2	2	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:61541176C>G	uc002ydr.1	-	4	1300	c.1036G>C	c.(1036-1038)GAT>CAT	p.D346H	DIDO1_uc002yds.1_Missense_Mutation_p.D346H|DIDO1_uc002ydt.1_Missense_Mutation_p.D346H|DIDO1_uc002ydu.1_Missense_Mutation_p.D346H|DIDO1_uc002ydv.1_Missense_Mutation_p.D346H|DIDO1_uc002ydw.1_Missense_Mutation_p.D346H|DIDO1_uc002ydx.1_Missense_Mutation_p.D346H|DIDO1_uc011aao.1_Missense_Mutation_p.D346H	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	346					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TCGGTGCCATCAGCATCTCCA	0.458													7	170					0	0	0	0	G	61541176	G	G	61541176	3	3	195	1	0	0	0	0	1	0	0	0	4544	826	29	2	5868	2	DIDO1	20	61541176	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	248695	61541176	1484344	289	36039											
SAMD10	140700	broad.mit.edu	37	chr20	62608706	62608706	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagtggcaggggatgctctCagctgacaccgtgtgctcca	8	8	13	12	1	1	1	1	1	1	0	3	2	2	2	2	3	3	4	2	3	1	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr20:62608706C>T	uc002yhm.2	-	2	320	c.145G>A	c.(145-147)GAG>AAG	p.E49K	SAMD10_uc002yhn.2_RNA	NM_080621	NP_542188	Q9BYL1	SAM10_HUMAN	sterile alpha motif domain containing 10	49											0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGGATGCTCTCAGCTGACACC	0.652													9	92					0	0	0	0	T	62608706	T	T	62608706	3	4	195	1	0	0	0	0	1	0	0	0	13880	835	29	2	479	2	SAMD10	20	62608706	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	1067530	62608706	416814	290	36040											
GABPA	2551	broad.mit.edu	37	chr21	27130510	27130510	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtcatctggaacttctccGaaaatgtatgaaattacagt	14	12	8	7	1	3	1	1	1	2	0	4	4	3	2	1	1	2	1	1	1	6	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr21:27130510G>A	uc002ylx.3	+	6	1270	c.743G>A	c.(742-744)CGA>CAA	p.R248Q	GABPA_uc002yly.3_Missense_Mutation_p.R248Q	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	248	PNT.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						GAACTTCTCCGAAAATGTATG	0.328													13	28					0	0	0	0	A	27130510	A	A	27130510	3	1	195	1	0	0	0	0	1	0	0	0	6191	1058	37	1	761	1	GABPA	21	27130510	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08		27130510	20999385	291	36041											
ADAMTS5	11096	broad.mit.edu	37	chr21	28338237	28338237	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggtgtagcgcgcgtgcttGaccgcgaagaagccgtcgag	8	6	17	10	7	0	2	0	1	0	1	1	4	0	2	2	1	3	2	2	1	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr21:28338237G>A	uc002ymg.2	-	1	1203	c.474C>T	c.(472-474)GTC>GTT	p.V158V		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	158					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GCGCGTGCTTGACCGCGAAGA	0.657													7	26					0	0	0	0	A	28338237	A	A	28338237	2	1	195	1	0	0	0	0	0	0	0	1	269	1277	45	2		2	ADAMTS5	21	28338237	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1207727	28338237	19791658	292	36042											
WRB	7485	broad.mit.edu	37	chr21	40762689	40762689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagcggagatccaggacatGaagcaggagctctccacagt	13	5	13	10	1	1	3	0	1	1	2	3	6	2	5	2	3	3	2	2	3	1	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr21:40762689G>A	uc002yxs.2	+	2	266	c.168G>A	c.(166-168)ATG>ATA	p.M56I	WRB_uc011aeo.1_RNA|WRB_uc011aep.1_Missense_Mutation_p.M56I|WRB_uc002yxt.3_Missense_Mutation_p.M22I|WRB_uc010goj.2_RNA	NM_004627	NP_004618	O00258	WRB_HUMAN	tryptophan rich basic protein isoform 1	56	Potential.					integral to membrane|nucleolus					0		Prostate(19;1.2e-06)				TCCAGGACATGAAGCAGGAGC	0.542													4	28					0	0	0	0	A	40762689	A	A	40762689	3	1	195	1	0	0	0	0	1	0	0	0	17469	1290	45	2	174	2	WRB	21	40762689	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	12424452	40762689	7367206	293	36043											
SLC19A1	6573	broad.mit.edu	37	chr21	46951984	46951984	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcaccggcgtgtagcgcaGgtagtcggtgagcaggaaca	10	5	16	10	4	0	1	0	1	0	0	1	2	0	2	1	4	4	5	1	4	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr21:46951984G>A	uc002zhl.1	-	3	387	c.268C>T	c.(268-270)CTG>TTG	p.L90L	SLC19A1_uc010gpy.1_Silent_p.L90L|SLC19A1_uc011aft.1_Silent_p.L50L|SLC19A1_uc002zhm.1_Silent_p.L90L|SLC19A1_uc010gpz.1_5'UTR	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	90	Cytoplasmic (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GTGTAGCGCAGGTAGTCGGTG	0.672													16	28					0	0	0	0	A	46951984	A	A	46951984	2	1	195	1	0	0	0	0	0	0	0	1	14493	991	35	4		4	SLC19A1	21	46951984	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	6189295	46951984	1177911	294	36044											
DGCR2	9993	broad.mit.edu	37	chr22	19076905	19076905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagttggcttcgtcgctctCatcctcgcaagtcgcccagc	6	10	9	16	4	1	0	1	0	1	0	7	0	2	0	2	1	1	4	2	1	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:19076905C>T	uc002zoq.1	-	2	426	c.178G>A	c.(178-180)GAG>AAG	p.E60K	DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Intron	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	60	Extracellular (Potential).|LDL-receptor class A.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					TCGTCGCTCTCATCCTCGCAA	0.607													14	123					0	0	0	0	T	19076905	T	T	19076905	3	4	195	1	0	0	0	0	1	0	0	0	4483	835	29	2	1510	2	DGCR2	22	19076905	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08		19076905	32227661	295	36045											
CLTCL1	8218	broad.mit.edu	37	chr22	19183840	19183840	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggggtggctcatcatggtGagcacagcattgtcatactc	8	11	13	9	0	3	1	3	1	0	0	4	1	3	1	0	4	3	3	0	4	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:19183840G>A	uc002zpb.2	-	27	4203	c.4128C>T	c.(4126-4128)CTC>CTT	p.L1376L	CLTCL1_uc011agv.1_Silent_p.L1376L|CLTCL1_uc011agw.1_Silent_p.L1355L|CLTCL1_uc011agt.1_Silent_p.L167L|CLTCL1_uc011agu.1_Silent_p.L167L|CLTCL1_uc010grm.1_Silent_p.L136L|CLTCL1_uc002zpe.2_3'UTR|CLTCL1_uc002zpd.1_Silent_p.L283L	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1376	Involved in binding clathrin light chain (By similarity).|Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TCATCATGGTGAGCACAGCAT	0.567			T	?	ALCL								8	72					0	0	0	0	A	19183840	A	A	19183840	2	1	195	1	0	0	0	0	0	0	0	1	3582	1277	45	2		2	CLTCL1	22	19183840	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	106935	19183840	32120726	296	36046											
CLTCL1	8218	broad.mit.edu	37	chr22	19209480	19209480	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaggacaccttacctatttCttttttctacttcagccacc	9	16	3	13	0	3	0	1	0	2	0	3	1	3	1	4	1	3	0	4	1	4	9			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:19209480C>G	uc002zpb.2	-	16	2630	c.2555G>C	c.(2554-2556)AGA>ACA	p.R852T	CLTCL1_uc011agv.1_Missense_Mutation_p.R852T|CLTCL1_uc011agw.1_Missense_Mutation_p.R852T	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	852	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TTACCTATTTCTTTTTTCTAC	0.418			T	?	ALCL								7	106					0	0	0	0	G	19209480	G	G	19209480	3	3	195	1	0	0	0	0	1	0	0	0	3582	913	32	2	2435	2	CLTCL1	22	19209480	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	25640	19209480	32095086	297	36047											
TBX1	6899	broad.mit.edu	37	chr22	19766783	19766783	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggaagtgaaagctgagacGtctaggaacacaccagagag	17	4	13	7	1	1	3	0	2	1	2	1	7	1	5	1	2	2	1	1	2	5	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:19766783G>A	uc002zqb.2	+	9	1179	c.1050G>A	c.(1048-1050)ACG>ACA	p.T350T	TBX1_uc002zqc.2_Intron	NM_080646	NP_542377	O43435	TBX1_HUMAN	T-box 1 isoform A	350					embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)	2	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				AAGCTGAGACGTCTAGGAACA	0.547													23	137					0	0	0	0	A	19766783	A	A	19766783	2	1	195	1	0	0	0	0	0	0	0	1	15716	1132	40	1		1	TBX1	22	19766783	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	557303	19766783	31537783	298	36048											
PI4KA	5297	broad.mit.edu	37	chr22	21157491	21157491	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttattacctgtgtggtactGactgtggtacttgtagagct	7	16	12	6	0	0	2	0	1	0	1	0	2	0	2	1	2	4	5	1	2	5	6			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:21157491G>A	uc002zsz.3	-	13	1636	c.1405C>T	c.(1405-1407)CAG>TAG	p.Q469*	PI4KA_uc010gsq.1_Nonsense_Mutation_p.Q527*	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	469					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GTGTGGTACTGACTGTGGTAC	0.547													14	158					0	0	0	0	A	21157491	A	A	21157491	4	1	195	1	0	0	0	0	0	1	0	0	11928	1299	45	2	4901	2	PI4KA	22	21157491	Nonsense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1390708	21157491	30147075	299	36049											
P2RX6	9127	broad.mit.edu	37	chr22	21377467	21377467	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaaaaacacagtcaccttCagcaagttcaacttctctaa	16	10	3	12	0	5	0	4	0	1	0	6	0	5	0	1	0	3	2	1	0	5	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:21377467C>T	uc010gsu.1	+	6	618	c.618C>T	c.(616-618)TTC>TTT	p.F206F	P2RX6_uc002ztz.2_Silent_p.F180F|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	206	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						CAGTCACCTTCAGCAAGTTCA	0.572													11	283					0	0	0	0	T	21377467	T	T	21377467	2	4	195	1	0	0	0	0	0	0	0	1	11398	825	29	2		2	P2RX6	22	21377467	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	219976	21377467	29927099	300	36050											
MYO18B	84700	broad.mit.edu	37	chr22	26343755	26343755	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgaggaccaggatgacctGaatgagctgatgcagaagca	14	6	14	7	0	0	6	0	5	0	1	0	9	0	8	2	2	3	3	2	2	2	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:26343755G>C	uc003abz.1	+	36	5959	c.5709G>C	c.(5707-5709)CTG>CTC	p.L1903L	MYO18B_uc003aca.1_Silent_p.L1784L|MYO18B_uc010guy.1_Silent_p.L1785L|MYO18B_uc010guz.1_Silent_p.L1783L|MYO18B_uc011aka.1_Silent_p.L1057L|MYO18B_uc011akb.1_Silent_p.L1416L	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1903	Tail.|Potential.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AGGATGACCTGAATGAGCTGA	0.557													9	18					0	0	0	0	C	26343755	C	C	26343755	2	2	195	1	0	0	0	0	0	0	0	1	10119	1277	45	2		2	MYO18B	22	26343755	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	4966288	26343755	24960811	301	36051											
CRYBA4	1413	broad.mit.edu	37	chr22	27026341	27026341	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccgggctaccgaggatttCagtatgtgctggaatgcgat	8	12	13	8	3	1	0	1	0	0	0	2	4	2	2	2	3	3	3	2	3	3	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:27026341C>T	uc003acz.3	+	6	516	c.481C>T	c.(481-483)CAG>TAG	p.Q161*		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	161	Beta/gamma crystallin 'Greek key' 4.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						CCGAGGATTTCAGTATGTGCT	0.537													12	35					0	0	0	0	T	27026341	T	T	27026341	4	4	195	1	0	0	0	0	0	1	0	0	3924	827	29	2	499	2	CRYBA4	22	27026341	Nonsense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	682586	27026341	24278225	302	36052											
TCN2	6948	broad.mit.edu	37	chr22	31010483	31010483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttccaccagggccaccattCtgtgggtgagtaggtcagac	8	10	12	11	0	2	2	1	1	1	1	3	2	3	2	4	3	0	1	4	3	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:31010483C>T	uc003aip.1	+	4	733	c.575C>T	c.(574-576)TCT>TTT	p.S192F	TCN2_uc003aiq.1_Missense_Mutation_p.S188F|TCN2_uc003air.1_Missense_Mutation_p.S165F	NM_000355	NP_000346	P20062	TCO2_HUMAN	transcobalamin II precursor	192	Cobalamin binding.				cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGCCACCATTCTGTGGGTGAG	0.602													9	17					0	0	0	0	T	31010483	T	T	31010483	3	4	195	1	0	0	0	0	1	0	0	0	15773	913	32	2	589	2	TCN2	22	31010483	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	3984142	31010483	20294083	303	36053											
FOXRED2	80020	broad.mit.edu	37	chr22	36886209	36886209	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcctgctctccactctgTgctgccaaaggctctcggta	6	10	11	14	1	3	0	0	0	3	0	5	1	3	1	3	3	4	4	3	3	2	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:36886209T>C	uc003apn.3	-	8	2009	c.1901A>G	c.(1900-1902)CAC>CGC	p.H634R	FOXRED2_uc003apm.3_Missense_Mutation_p.H186R|FOXRED2_uc003apo.3_Missense_Mutation_p.H634R|FOXRED2_uc003app.3_Missense_Mutation_p.H634R	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	634					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						CTCCACTCTGTGCTGCCAAAG	0.637													12	100					0	0	0	0	C	36886209	C	C	36886209	3	2	195	1	0	0	0	0	1	0	0	0	6068	1696	59	5	157	5	FOXRED2	22	36886209	Missense_Mutation	SNP	T	TCGA-CV-6936-01A-11D-1912-08	5875726	36886209	14418357	304	36054											
MKL1	57591	broad.mit.edu	37	chr22	40825650	40825650	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggactcaacaggaaggatGttcttctccaccagctccat	10	10	8	13	0	3	0	1	0	2	0	5	3	4	3	3	3	2	2	3	3	2	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:40825650G>T	uc003ayv.1	-	4	468	c.261C>A	c.(259-261)AAC>AAA	p.N87K	MKL1_uc003ayw.1_Missense_Mutation_p.N87K|MKL1_uc010gye.1_Missense_Mutation_p.N87K|MKL1_uc010gyf.1_Missense_Mutation_p.N87K	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	87	RPEL 2.|Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CAGGAAGGATGTTCTTCTCCA	0.577			T	RBM15	acute megakaryocytic leukemia								35	14					1.99505e-19	3.88128e-19	1	0	T	40825650	T	T	40825650	3	4	195	1	0	0	0	0	1	0	0	0	9654	1368	48	4	2570	4	MKL1	22	40825650	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	3939441	40825650	10478916	305	36055											
PLXNB2	23654	broad.mit.edu	37	chr22	50721260	50721260	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccagaagcatctggcccCgtgtcgcctgggggccagtg	5	7	14	15	2	1	1	0	0	1	1	3	1	2	1	6	3	1	1	6	3	1	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chr22:50721260C>T	uc003bkv.3	-	18	2973	c.2867G>A	c.(2866-2868)CGG>CAG	p.R956Q	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	956	Extracellular (Potential).|IPT/TIG 2.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CATCTGGCCCCGTGTCGCCTG	0.672													4	28					0	0	0	0	T	50721260	T	T	50721260	3	4	195	1	0	0	0	0	1	0	0	0	12179	652	23	1	2729	1	PLXNB2	22	50721260	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	9895610	50721260	583306	306	36056											
ASMTL	8623	broad.mit.edu	37	chrX	1554652	1554652	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaatcagccccccgactgtCtgtgagaggaagggacagag	12	5	14	10	1	2	3	1	1	1	3	2	7	2	5	3	2	1	0	3	2	2	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:1554652C>T	uc004cpx.1	-	4	385	c.274_splice	c.e4-1	p.T92_splice	ASMTL_uc011mhe.1_Intron|ASMTL_uc004cpy.1_Splice_Site_p.T76_splice|ASMTL_uc011mhf.1_Splice_Site_p.T34_splice	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like						melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCCCGACTGTCTGTGAGAGGA	0.587													11	69					0	0	0	0	T	1554652	T	T	1554652	5	4	195	1	0	0	0	0	0	0	1	0	1048	927	32	2	1632	2	ASMTL	23	1554652	Splice_Site	SNP	C	TCGA-CV-6936-01A-11D-1912-08		1554652	153715908	307	36057											
CNKSR2	22866	broad.mit.edu	37	chrX	21545080	21545080	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttctgccctccaggatctCtacattccccctcctcctgc	5	12	5	19	0	2	0	0	0	2	0	7	1	6	1	6	1	3	1	6	1	1	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:21545080C>T	uc004czx.1	+	10	1089	c.1053C>T	c.(1051-1053)CTC>CTT	p.L351L	CNKSR2_uc004czw.2_Silent_p.L351L|CNKSR2_uc011mjn.1_Silent_p.L302L|CNKSR2_uc011mjo.1_Silent_p.L351L|CNKSR2_uc004czy.2_5'UTR	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	351	DUF1170.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						TCCAGGATCTCTACATTCCCC	0.483													16	137					0	0	0	0	T	21545080	T	T	21545080	2	4	195	1	0	0	0	0	0	0	0	1	3622	900	32	2		2	CNKSR2	23	21545080	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	19990428	21545080	133725480	308	36058											
MID1IP1	58526	broad.mit.edu	37	chrX	38664680	38664680	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcacactgtgctctcgaaaCtcacgcgcaaagccaacatc	12	7	7	15	3	2	0	1	0	1	0	4	1	2	0	1	0	5	3	1	0	3	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:38664680C>G	uc004dei.3	+	3	905	c.481C>G	c.(481-483)CTC>GTC	p.L161V	MID1IP1_uc010ngz.2_Missense_Mutation_p.L161V|MID1IP1_uc004dej.3_Missense_Mutation_p.L161V	NM_001098790	NP_001092260	Q9NPA3	M1IP1_HUMAN	MID1 interacting G12-like protein	161					lipid biosynthetic process|negative regulation of microtubule depolymerization|positive regulation of fatty acid biosynthetic process|positive regulation of ligase activity|protein polymerization	cytosol|microtubule|nucleus					0						GCTCTCGAAACTCACGCGCAA	0.627													11	7					0	0	0	0	G	38664680	G	G	38664680	3	3	195	1	0	0	0	0	1	0	0	0	9630	565	20	4	483	4	MID1IP1	23	38664680	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	17119600	38664680	116605880	309	36059											
ATP6AP2	10159	broad.mit.edu	37	chrX	40456555	40456555	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccattcactccttattttctGaggaaactcctgttgttttg	7	18	6	10	0	2	1	1	1	1	0	4	2	4	2	3	1	1	2	3	1	2	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:40456555G>C	uc004det.2	+	4	457	c.355G>C	c.(355-357)GAG>CAG	p.E119Q	ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_Missense_Mutation_p.E43Q|ATP6AP2_uc011mkm.1_Intron|ATP6AP2_uc011mkn.1_Intron|ATP6AP2_uc004deu.1_5'Flank	NM_005765	NP_005756	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory	119	Extracellular (Potential).				angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0						CTTATTTTCTGAGGAAACTCC	0.323													8	21					0	0	0	0	C	40456555	C	C	40456555	3	2	195	1	0	0	0	0	1	0	0	0	1169	1291	45	2	369	2	ATP6AP2	23	40456555	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08	1791875	40456555	114814005	310	36060											
UBA1	7317	broad.mit.edu	37	chrX	47074277	47074277	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgagctgtgctgtaacgaCgagagcggcgaggatgtcga	9	8	16	8	5	0	2	0	1	0	1	1	7	0	3	0	2	4	3	0	2	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:47074277C>T	uc004dhj.3	+	26	3277	c.3126C>T	c.(3124-3126)GAC>GAT	p.D1042D	UBA1_uc004dhk.3_Silent_p.D1042D|UBA1_uc004dhm.2_Silent_p.D490D	NM_153280	NP_695012	P22314	UBA1_HUMAN	ubiquitin-activating enzyme E1	1042					cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1						GCTGTAACGACGAGAGCGGCG	0.627													23	16					0	0	0	0	T	47074277	T	T	47074277	2	4	195	1	0	0	0	0	0	0	0	1	16895	535	19	1		1	UBA1	23	47074277	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	6617722	47074277	108196283	311	36061											
UBQLN2	29978	broad.mit.edu	37	chrX	56591223	56591223	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctctggggaaggtacgcAgccttcccgcacagaaaatc	10	7	10	14	2	1	1	0	0	1	1	4	2	3	2	3	3	2	3	3	3	4	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:56591223A>T	uc004dus.2	+	1	1152	c.917A>T	c.(916-918)CAG>CTG	p.Q306L	UBQLN2_uc011moq.1_Missense_Mutation_p.Q306L	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	306						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						GAAGGTACGCAGCCTTCCCGC	0.562													11	3					0	0	0	0	T	56591223	T	T	56591223	3	4	195	1	0	0	0	0	1	0	0	0	16965	188	7	5	919	5	UBQLN2	23	56591223	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	9516946	56591223	98679337	312	36062											
ARR3	407	broad.mit.edu	37	chrX	69489243	69489243	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctatatagccaacatgtccaAgtaagaattccttctaatcc	14	12	4	11	0	1	1	0	0	1	1	4	1	4	1	4	0	2	1	4	0	8	7			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:69489243A>C	uc004dyb.2	+	2	76	c.8A>C	c.(7-9)AAG>ACG	p.K3T	ARR3_uc004dya.2_Missense_Mutation_p.K3T	NM_004312	NP_004303	P36575	ARRC_HUMAN	arrestin 3, retinal (X-arrestin)	3					signal transduction|visual perception	cytoplasm|soluble fraction				large_intestine(2)|ovary(2)	4						AACATGTCCAAGTAAGAATTC	0.423													11	5					0	0	0	0	C	69489243	C	C	69489243	3	2	195	1	0	0	0	0	1	0	0	0	981	86	3	5	10	5	ARR3	23	69489243	Missense_Mutation	SNP	A	TCGA-CV-6936-01A-11D-1912-08	12898020	69489243	85781317	313	36063											
PGAM4	441531	broad.mit.edu	37	chrX	77224532	77224532	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctccatgatagcctcttCagagagaccctccacatgct	10	9	7	15	0	2	3	1	1	1	2	4	4	4	3	4	0	3	2	4	0	1	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:77224532C>G	uc004ecy.1	-	1	604	c.604G>C	c.(604-606)GAA>CAA	p.E202Q	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	202					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						ATAGCCTCTTCAGAGAGACCC	0.512													4	179					0	0	0	0	G	77224532	G	G	77224532	3	3	195	1	0	0	0	0	1	0	0	0	11830	835	29	2	164	2	PGAM4	23	77224532	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	7735289	77224532	78046028	314	36064											
NAP1L3	4675	broad.mit.edu	37	chrX	92927456	92927456	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagcctttcctcaggaactCttttatgagtctctcttact	8	16	6	11	0	4	1	1	1	3	0	6	3	5	2	2	1	3	0	2	1	4	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:92927456C>G	uc004efq.2	-	1	1153	c.848G>C	c.(847-849)AGA>ACA	p.R283T	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	283					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						CTCAGGAACTCTTTTATGAGT	0.453													3	87					0	0	0	0	G	92927456	G	G	92927456	3	3	195	1	0	0	0	0	1	0	0	0	10211	913	32	2	676	2	NAP1L3	23	92927456	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	15702924	92927456	62343104	315	36065											
TCEAL4	79921	broad.mit.edu	37	chrX	102842017	102842017	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggggctggctcattacctCaaggagtataaagaggccat	13	8	12	8	0	2	1	2	0	0	1	2	2	2	2	2	5	1	3	2	5	6	3			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:102842017C>T	uc004ekl.2	+	3	707	c.414C>T	c.(412-414)CTC>CTT	p.L138L	TCEAL4_uc004ekn.2_Silent_p.L138L|TCEAL4_uc004ekm.2_Silent_p.L138L|TCEAL4_uc004eko.2_Silent_p.L138L	NM_024863	NP_079139	Q96EI5	TCAL4_HUMAN	transcription elongation factor A (SII)-like 4	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						CTCATTACCTCAAGGAGTATA	0.433													11	117					0	0	0	0	T	102842017	T	T	102842017	2	4	195	1	0	0	0	0	0	0	0	1	15739	813	29	2		2	TCEAL4	23	102842017	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	9914561	102842017	52428543	316	36066											
PLP1	5354	broad.mit.edu	37	chrX	103041526	103041526	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgactacaagaccaccatCtgcggcaagggcctgagcgc	10	4	13	14	3	1	2	0	1	1	1	1	3	1	2	3	3	3	1	3	3	3	1			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:103041526C>T	uc010nov.2	+	4	604	c.324C>T	c.(322-324)ATC>ATT	p.I108I	RAB9B_uc004eli.1_Intron|PLP1_uc004elk.2_Silent_p.I108I|PLP1_uc004elj.2_Silent_p.I108I|PLP1_uc011msf.1_Silent_p.I53I|PLP1_uc010now.1_Silent_p.I112I|PLP1_uc010nox.2_Silent_p.I62I	NM_001128834	NP_001122306	P60201	MYPR_HUMAN	proteolipid protein 1 isoform 1	108	Cytoplasmic (Probable).				cell death|synaptic transmission	integral to membrane				ovary(1)	1						AGACCACCATCTGCGGCAAGG	0.582													12	110					0	0	0	0	T	103041526	T	T	103041526	2	4	195	1	0	0	0	0	0	0	0	1	12159	903	32	2		2	PLP1	23	103041526	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	199509	103041526	52229034	317	36067											
SERPINA7	6906	broad.mit.edu	37	chrX	105280474	105280474	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accatgatggtgtttggcttGaggtcttgaattagacccac	9	13	11	8	0	1	4	0	3	1	1	1	4	1	4	2	3	0	2	2	3	2	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:105280474G>A	uc004eme.1	-	1	592	c.576C>T	c.(574-576)CTC>CTT	p.L192L	SERPINA7_uc010npd.2_Silent_p.L192L|SERPINA7_uc010npe.1_Silent_p.L192L	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	192					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	TGTTTGGCTTGAGGTCTTGAA	0.418													18	103					0	0	0	0	A	105280474	A	A	105280474	2	1	195	1	0	0	0	0	0	0	0	1	14159	1277	45	2		2	SERPINA7	23	105280474	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	2238948	105280474	49990086	318	36068											
CHRDL1	91851	broad.mit.edu	37	chrX	109922601	109922601	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accagcttgaagtgaggaagCtcctcaaacatcctcttgga	12	9	9	11	0	2	2	1	2	1	0	4	4	4	4	3	2	3	2	3	2	3	2			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:109922601C>T	uc004eou.3	-	11	1558	c.1209G>A	c.(1207-1209)GAG>GAA	p.E403E	CHRDL1_uc004eov.2_Silent_p.E392E|CHRDL1_uc004eow.2_Silent_p.E401E|CHRDL1_uc010nps.2_Silent_p.E402E|CHRDL1_uc004eot.2_Silent_p.E322E|CHRDL1_uc011mss.1_Silent_p.E317E	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	395					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						AGTGAGGAAGCTCCTCAAACA	0.453													45	15					0	0	0	0	T	109922601	T	T	109922601	2	4	195	1	0	0	0	0	0	0	0	1	3388	796	28	4		4	CHRDL1	23	109922601	Silent	SNP	C	TCGA-CV-6936-01A-11D-1912-08	4642127	109922601	45347959	319	36069											
GPC4	2239	broad.mit.edu	37	chrX	132548982	132548982	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagagaagcgcgggcaagccGaaccgtgccatggtgcgggc	9	3	17	12	5	0	1	0	0	0	1	0	3	0	1	3	3	5	1	3	3	3	0			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:132548982G>A	uc004exc.1	-	1	224	c.12C>T	c.(10-12)TTC>TTT	p.F4F	GPC4_uc011mvg.1_5'Flank	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	4					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					CGGGCAAGCCGAACCGTGCCA	0.701													7	20					0	0	0	0	A	132548982	A	A	132548982	2	1	195	1	0	0	0	0	0	0	0	1	6638	1049	37	1		1	GPC4	23	132548982	Silent	SNP	G	TCGA-CV-6936-01A-11D-1912-08	22626381	132548982	22721578	320	36070											
ATP2B3	492	broad.mit.edu	37	chrX	152845713	152845713	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tacctcttcagtgttttcctCcagtcccgggagcccgctcc	4	12	8	17	2	2	0	1	0	1	0	6	1	6	1	6	1	2	2	6	1	1	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrX:152845713C>G	uc004fht.1	+	20	3746	c.3620C>G	c.(3619-3621)TCC>TGC	p.S1207C	ATP2B3_uc004fhs.1_3'UTR|ATP2B3_uc010nuf.1_Missense_Mutation_p.S344C|ATP2B3_uc004fhu.1_Missense_Mutation_p.S159C	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	1207	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGTTTTCCTCCAGTCCCGGG	0.473													3	75					0	0	0	0	G	152845713	G	G	152845713	3	3	195	1	0	0	0	0	1	0	0	0	1143	855	30	2	3856	2	ATP2B3	23	152845713	Missense_Mutation	SNP	C	TCGA-CV-6936-01A-11D-1912-08	20296731	152845713	2424847	321	36071											
KDM5D	8284	broad.mit.edu	37	chrY	21877710	21877710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acagtgttcccatgctcaccGgaggtactgtcggctactag	8	10	11	12	2	1	0	1	0	0	0	3	1	2	1	2	3	3	4	2	3	3	4			TCGA-CV-6936-01A-11D-1912-08	TCGA-CV-6936-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d4bdd75-d967-40b2-b55d-99e59cc7e125	31d97fa4-4f9b-4753-99ea-73b8cd1e4efc	g.chrY:21877710G>A	uc004fug.2	-	16	2500	c.2212C>T	c.(2212-2214)CGG>TGG	p.R738W	KDM5D_uc011naz.1_Missense_Mutation_p.R769W|KDM5D_uc010nwy.2_Missense_Mutation_p.R681W|KDM5D_uc011nba.1_Missense_Mutation_p.R738W|KDM5D_uc004fuf.2_5'Flank	NM_004653	NP_004644	Q9BY66	KDM5D_HUMAN	jumonji, AT rich interactive domain 1D isoform	738					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1					Vitamin C(DB00126)	CATGCTCACCGGAGGTACTGT	0.552													67	9					0	0	0	0	A	21877710	A	A	21877710	3	1	195	1	0	0	0	0	1	0	0	0	8175	1130	39	1	2455	1	KDM5D	24	21877710	Missense_Mutation	SNP	G	TCGA-CV-6936-01A-11D-1912-08		21877710	37495856	322	36072											
PRAMEF1	65121	broad.mit.edu	37	chr1	12854334	12854334	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtgctgtagtaagctggtCaattatctaacgccgattaa	11	13	9	8	2	2	0	1	0	1	0	2	1	2	0	1	1	3	4	1	1	6	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:12854334C>G	uc001auj.1	+	3	661	c.558C>G	c.(556-558)GTC>GTG	p.V186V		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	186											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTAAGCTGGTCAATTATCTAA	0.423													10	635					0	0	0	0	G	12854334	G	G	12854334	2	3	196	1	0	0	0	0	0	0	0	1	12485	813	29	2		2	PRAMEF1	1	12854334	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08		12854334	236396287	1	36073											
TFAP2E	339488	broad.mit.edu	37	chr1	36054125	36054125	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcctcccgagtgcctcaacGcctccctcctggggggtgtc	3	8	12	18	3	1	0	1	0	0	0	5	1	4	0	6	3	2	0	6	3	1	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:36054125G>A	uc010ohy.1	+	4	965	c.757G>A	c.(757-759)GCC>ACC	p.A253T	PSMB2_uc001bzd.1_Intron	NM_178548	NP_848643	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating	253						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GTGCCTCAACGCCTCCCTCCT	0.647													24	65					0	0	0	0	A	36054125	A	A	36054125	3	1	196	1	0	0	0	0	1	0	0	0	15857	1087	38	1	771	1	TFAP2E	1	36054125	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	23199791	36054125	213196496	2	36074											
ZMYND12	84217	broad.mit.edu	37	chr1	42905661	42905664	+	Frame_Shift_Del	DEL	ATAG	-	-																															gactgtccactgggcttggaAtagatattcttcagcctgaa																										TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:42905661_42905664delATAG	uc001chj.2	-	4	727_730	c.457_460delCTAT	c.(457-462)CTATTCfs	p.L153fs	ZMYND12_uc010ojt.1_Frame_Shift_Del_p.L43fs	NM_032257	NP_115633	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12 isoform 1	153_154						intracellular	zinc ion binding			ovary(1)	1	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGGGCTTGGAATAGATATTCTTCA	0.426													---	---	---								-	42905664	-	-	42905661	7	5	196	1	0	1	0	1	0	0	0	0	17774	101	4	0	657	0	ZMYND12	1	42905661	Frame_Shift_Del	DEL	ATAG	TCGA-CV-6937-01A-11D-2012-08	6851536	42905661	206344960	3	36075											
ST6GALNAC3	256435	broad.mit.edu	37	chr1	76878016	76878016	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaaaaagacagttggtatCtatccgaatgcccaaatata	16	11	7	7	1	1	2	0	1	1	1	2	3	2	2	2	1	1	2	2	1	8	6			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:76878016C>G	uc001dhh.2	+	3	700	c.537C>G	c.(535-537)ATC>ATG	p.I179M	ST6GALNAC3_uc001dhg.3_Missense_Mutation_p.I179M|ST6GALNAC3_uc010orh.1_Missense_Mutation_p.I114M	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	179	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						CAGTTGGTATCTATCCGAATG	0.423													8	61					0	0	0	0	G	76878016	G	G	76878016	3	3	196	1	0	0	0	0	1	0	0	0	15291	903	32	2	547	2	ST6GALNAC3	1	76878016	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	33972355	76878016	172372605	4	36076											
PIGK	10026	broad.mit.edu	37	chr1	77558068	77558068	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcatcaagtctaaaaaatGaacttcatatgcttaattcc	16	13	3	9	0	4	1	3	1	1	0	5	1	5	1	1	0	2	1	1	0	7	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:77558068G>A	uc001dhk.2	-	11	1224	c.1179C>T	c.(1177-1179)TTC>TTT	p.F393F	PIGK_uc010orj.1_Silent_p.F317F|PIGK_uc009wbx.2_Silent_p.F299F	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	393	Cytoplasmic (Potential).			Missing: Loss of activity.	attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						TCTAAAAAATGAACTTCATAT	0.328													9	51					0	0	0	0	A	77558068	A	A	77558068	2	1	196	1	0	0	0	0	0	0	0	1	11945	1281	45	2		2	PIGK	1	77558068	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	680052	77558068	171692553	5	36077											
SPAG17	200162	broad.mit.edu	37	chr1	118640375	118640375	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagcaacatcaaagagatttGtttcaggtttctcattattc	12	15	7	7	0	3	1	3	0	1	1	5	3	3	1	0	1	2	3	0	1	3	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:118640375G>T	uc001ehk.2	-	7	997	c.929C>A	c.(928-930)ACA>AAA	p.T310K		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	310						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AAAGAGATTTGTTTCAGGTTT	0.378													326	47					2.44235e-143	1.5296e-142	1	0	T	118640375	T	T	118640375	3	4	196	1	0	0	0	0	1	0	0	0	15045	1377	48	4	5910	4	SPAG17	1	118640375	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	41082307	118640375	130610246	6	36078											
NOTCH2	4853	broad.mit.edu	37	chr1	120458562	120458562	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacatctcattgtactgggtCtcattcacctccatgcggtt	8	14	7	12	1	3	0	3	0	2	0	6	0	4	0	2	2	3	2	2	2	2	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:120458562C>G	uc001eik.2	-	34	7039	c.6783G>C	c.(6781-6783)GAG>GAC	p.E2261D		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	2261	Cytoplasmic (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGTACTGGGTCTCATTCACCT	0.557			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				71	250					0	0	0	0	G	120458562	G	G	120458562	3	3	196	1	0	0	0	0	1	0	0	0	10602	912	32	2	636	2	NOTCH2	1	120458562	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	1818187	120458562	128792059	7	36079											
S100A10	6281	broad.mit.edu	37	chr1	151955750	151955750	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccactttgccatctctacaCtggtccaggtccttcattat	7	14	5	15	0	2	0	1	0	1	0	5	0	4	0	4	2	2	0	4	2	2	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:151955750C>A	uc001ezl.2	-	3	691	c.183G>T	c.(181-183)CAG>CAT	p.Q61H		NM_002966	NP_002957	P60903	S10AA_HUMAN	S100 calcium binding protein A10	61	Ancestral calcium site.				signal transduction		calcium ion binding|receptor binding				0	Melanoma(130;0.0648)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CATCTCTACACTGGTCCAGGT	0.423													26	124					3.28513e-13	2.00598e-12	1	0	A	151955750	A	A	151955750	3	1	196	1	0	0	0	0	1	0	0	0	13837	564	20	4	114	4	S100A10	1	151955750	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	31497188	151955750	97294871	8	36080											
TCHH	7062	broad.mit.edu	37	chr1	152081918	152081918	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgctgggattgtctgtcgcGcagctgggaatcttccaact	6	13	12	10	2	2	0	0	0	2	0	4	2	3	2	1	2	3	3	1	2	2	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:152081918G>A	uc001ezp.2	-	2	3775	c.3775C>T	c.(3775-3777)CGC>TGC	p.R1259C	TCHH_uc009wne.1_Missense_Mutation_p.R1259C	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1259					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTGTCGCGCAGCTGGGAA	0.537													29	93					0	0	0	0	A	152081918	A	A	152081918	3	1	196	1	0	0	0	0	1	0	0	0	15766	1087	38	1	2060	1	TCHH	1	152081918	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	126168	152081918	97168703	9	36081											
FCRL3	115352	broad.mit.edu	37	chr1	157666098	157666098	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgggccggatctctagattCacattagacacagggactcc	10	9	11	11	1	2	2	1	0	1	2	4	4	3	4	2	3	0	0	2	3	2	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:157666098C>T	uc001frb.2	-	7	1156	c.864G>A	c.(862-864)GTG>GTA	p.V288V	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.V288V|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.V14V|FCRL3_uc001frc.1_Silent_p.V288V	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	288	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TCTCTAGATTCACATTAGACA	0.522													14	97					0	0	0	0	T	157666098	T	T	157666098	2	4	196	1	0	0	0	0	0	0	0	1	5828	813	29	2		2	FCRL3	1	157666098	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	5584180	157666098	91584523	10	36082											
PIGM	93183	broad.mit.edu	37	chr1	160001164	160001164	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acacagtagccacaagcctgGcggcgccccagccccttcag	9	4	10	18	2	1	0	1	0	0	0	1	0	1	0	6	2	3	1	6	2	2	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:160001164G>A	uc001fuv.1	-	1	620	c.366C>T	c.(364-366)CGC>CGT	p.R122R		NM_145167	NP_660150	Q9H3S5	PIGM_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	122	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CACAAGCCTGGCGGCGCCCCA	0.577													12	64					0	0	0	0	A	160001164	A	A	160001164	2	1	196	1	0	0	0	0	0	0	0	1	11947	1190	42	4		4	PIGM	1	160001164	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	2335066	160001164	89249457	11	36083											
DDR2	4921	broad.mit.edu	37	chr1	162737067	162737067	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactcggatcctgattggctGcttggtggccatcatcttta	6	14	10	11	1	2	1	1	1	1	0	4	2	3	2	2	4	1	2	2	4	1	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:162737067G>C	uc001gcf.2	+	12	1676	c.1211G>C	c.(1210-1212)TGC>TCC	p.C404S	DDR2_uc001gcg.2_Missense_Mutation_p.C404S	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	404	Helical; (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			CTGATTGGCTGCTTGGTGGCC	0.483													30	165					0	0	0	0	C	162737067	C	C	162737067	3	2	196	1	0	0	0	0	1	0	0	0	4354	1319	46	4	1245	4	DDR2	1	162737067	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	2735903	162737067	86513554	12	36084											
DUSP27	92235	broad.mit.edu	37	chr1	167088617	167088617	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccagtacctgggtgtagAggtggatgactttcctgagg	8	11	15	7	0	0	3	0	2	0	1	2	5	2	4	3	4	1	2	3	4	2	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:167088617A>G	uc001geb.1	+	4	569	c.569A>G	c.(568-570)GAG>GGG	p.E190G		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	190					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CTGGGTGTAGAGGTGGATGAC	0.557													15	47					0	0	0	0	G	167088617	G	G	167088617	3	3	196	1	0	0	0	0	1	0	0	0	4846	304	11	5	583	5	DUSP27	1	167088617	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	4351550	167088617	82162004	13	36085											
DCAF6	55827	broad.mit.edu	37	chr1	167971802	167971802	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcaaggccggagagtgaacGagaacgagatggtaactata	16	5	14	6	3	0	4	0	1	0	3	0	7	0	4	1	3	4	2	1	3	6	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:167971802G>A	uc001gew.2	+	8	1228	c.986G>A	c.(985-987)CGA>CAA	p.R329Q	DCAF6_uc001gev.2_Missense_Mutation_p.R329Q|DCAF6_uc001gex.2_Missense_Mutation_p.R329Q|DCAF6_uc010plk.1_Missense_Mutation_p.R298Q|DCAF6_uc001gey.2_Missense_Mutation_p.R182Q	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	329					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GAGAGTGAACGAGAACGAGAT	0.338													12	84					0	0	0	0	A	167971802	A	A	167971802	3	1	196	1	0	0	0	0	1	0	0	0	4291	1058	37	1	1016	1	DCAF6	1	167971802	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	883185	167971802	81278819	14	36086											
TIPRL	261726	broad.mit.edu	37	chr1	168153231	168153231	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgggtctggctttggaattGagttcaatgctacagatgcg	9	13	13	6	1	2	2	1	1	1	1	2	3	2	3	0	3	3	3	0	3	3	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:168153231G>A	uc001gfg.2	+	2	341	c.196G>A	c.(196-198)GAG>AAG	p.E66K	TIPRL_uc001gfh.2_Missense_Mutation_p.E66K|TIPRL_uc001gff.2_Missense_Mutation_p.E66K	NM_152902	NP_690866	O75663	TIPRL_HUMAN	TIP41, TOR signalling pathway regulator-like	66					DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			ovary(1)	1	all_hematologic(923;0.215)					CTTTGGAATTGAGTTCAATGC	0.428													17	72					0	0	0	0	A	168153231	A	A	168153231	3	1	196	1	0	0	0	0	1	0	0	0	15992	1291	45	2	202	2	TIPRL	1	168153231	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	181429	168153231	81097390	15	36087											
TNN	63923	broad.mit.edu	37	chr1	175053061	175053072	+	Splice_Site	DEL	TGACATCACTGG	-	-																															agtgaccccaagagccgataTgacatcactggtaagagcca																										TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:175053061_175053072delTGACATCACTGG	uc001gkl.1	+	5	1347	c.1234_splice	c.e5+1	p.G412_splice	TNN_uc010pmx.1_Splice_Site_p.G412_splice	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor						cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGAGCCGATATGACATCACTGGTAAGAGCCAT	0.542													---	---	---								-	175053072	-	-	175053061	8	5	196	1	0	1	0	1	0	0	1	0	16389	1471	51	0	1238	0	TNN	1	175053061	Splice_Site	DEL	TGACATCACTGG	TCGA-CV-6937-01A-11D-2012-08	6899830	175053061	74197560	16	36088											
ASTN1	460	broad.mit.edu	37	chr1	177000057	177000057	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ataatattatctttatacttGttcatcagtgacagcttggc	11	17	6	7	0	3	1	2	1	1	0	3	1	3	1	0	1	2	2	0	1	5	9			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:177000057G>T	uc001glc.2	-	4	1109	c.897C>A	c.(895-897)AAC>AAA	p.N299K	ASTN1_uc001glb.1_Missense_Mutation_p.N299K|ASTN1_uc001gld.1_Missense_Mutation_p.N299K|ASTN1_uc009wwx.1_Missense_Mutation_p.N299K|ASTN1_uc001gle.3_RNA|MIR488_hsa-mir-488|MI0003123_5'Flank	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	299					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CTTTATACTTGTTCATCAGTG	0.443													9	67					7.48243e-07	4.48487e-06	1	0	T	177000057	T	T	177000057	3	4	196	1	0	0	0	0	1	0	0	0	1066	1368	48	4	3071	4	ASTN1	1	177000057	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	1946996	177000057	72250564	17	36089											
CFHR4	10877	broad.mit.edu	37	chr1	196882040	196882040	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaaatggatggtcagcacaaCcaatttgcattagtaagtga	16	10	9	6	0	1	1	1	1	0	0	1	2	1	2	1	2	3	3	1	2	6	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:196882040C>A	uc001gto.2	+	3	496	c.427C>A	c.(427-429)CCA>ACA	p.P143T	CFHR4_uc009wyy.2_Missense_Mutation_p.P389T|CFHR4_uc001gtp.2_Missense_Mutation_p.P390T	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	143	Sushi 2.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						GTCAGCACAACCAATTTGCAT	0.303													42	75					5.85753e-14	3.59925e-13	1	0	A	196882040	A	A	196882040	3	1	196	1	0	0	0	0	1	0	0	0	3302	507	18	4	437	4	CFHR4	1	196882040	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	19881983	196882040	52368581	18	36090											
KIF21B	23046	broad.mit.edu	37	chr1	200944711	200944711	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggatgtctccctggatggcGagacactcgatgccatcgta	9	9	12	11	3	1	1	0	0	1	1	4	5	1	3	2	3	1	1	2	3	1	1	rs150393728		TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:200944711G>A	uc001gvs.1	-	33	4847	c.4530C>T	c.(4528-4530)CTC>CTT	p.L1510L	KIF21B_uc001gvr.1_Silent_p.L1497L|KIF21B_uc009wzl.1_Silent_p.L1510L|KIF21B_uc010ppn.1_Silent_p.L1497L	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1510	WD 5.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						CCTGGATGGCGAGACACTCGA	0.607													9	77					0	0	0	0	A	200944711	A	A	200944711	2	1	196	1	0	0	0	0	0	0	0	1	8328	1045	37	1		1	KIF21B	1	200944711	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	4062671	200944711	48305910	19	36091											
TRAF3IP3	80342	broad.mit.edu	37	chr1	209949072	209949072	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caactccacgtgcttcagtcCaaactgcaggtaccaggcac	11	7	8	15	1	1	0	1	0	0	0	3	0	3	0	3	2	5	4	3	2	3	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:209949072C>A	uc001hho.2	+	11	1334	c.1044C>A	c.(1042-1044)TCC>TCA	p.S348S	TRAF3IP3_uc001hhl.2_Silent_p.S328S|TRAF3IP3_uc001hhm.1_Silent_p.S348S|TRAF3IP3_uc001hhn.2_Silent_p.S328S|TRAF3IP3_uc009xcr.2_Silent_p.S348S	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	348	Cytoplasmic (Potential).|Potential.					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		TGCTTCAGTCCAAACTGCAGG	0.582													8	40					0.000157383	0.000899202	1	0	A	209949072	A	A	209949072	2	1	196	1	0	0	0	0	0	0	0	1	16509	581	21	4		4	TRAF3IP3	1	209949072	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	9004361	209949072	39301549	20	36092											
TMEM206	55248	broad.mit.edu	37	chr1	212553337	212553337	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggaggaagaccagctcccGctttttcacttcccggggcc	6	9	11	15	2	1	1	1	0	0	1	3	3	3	3	4	4	1	2	4	4	1	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:212553337G>A	uc001hjc.3	-	5	706	c.538C>T	c.(538-540)CGG>TGG	p.R180W	TMEM206_uc010pte.1_Missense_Mutation_p.R241W	NM_018252	NP_060722	Q9H813	TM206_HUMAN	transmembrane protein 206	180	Extracellular (Potential).					integral to membrane				breast(1)	1				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		ACCAGCTCCCGCTTTTTCACT	0.537													34	72					0	0	0	0	A	212553337	A	A	212553337	3	1	196	1	0	0	0	0	1	0	0	0	16197	1086	38	1	530	1	TMEM206	1	212553337	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	2604265	212553337	36697284	21	36093											
ESRRG	2104	broad.mit.edu	37	chr1	216737606	216737606	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gataaccaccaactctcggtCggccaagtcacacagtgtag	12	7	9	13	2	2	0	1	0	1	0	4	1	2	0	3	2	2	1	3	2	4	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr1:216737606C>A	uc001hkw.1	-	5	983	c.817G>T	c.(817-819)GAC>TAC	p.D273Y	ESRRG_uc001hky.1_Missense_Mutation_p.D250Y|ESRRG_uc009xdp.1_Missense_Mutation_p.D250Y|ESRRG_uc001hkz.1_Missense_Mutation_p.D211Y|ESRRG_uc010puc.1_Missense_Mutation_p.D250Y|ESRRG_uc001hla.1_Missense_Mutation_p.D250Y|ESRRG_uc001hlb.1_Missense_Mutation_p.D250Y|ESRRG_uc010pud.1_Missense_Mutation_p.D81Y|ESRRG_uc001hlc.1_Missense_Mutation_p.D250Y|ESRRG_uc001hld.1_Missense_Mutation_p.D250Y|ESRRG_uc001hkx.1_Missense_Mutation_p.D285Y|ESRRG_uc009xdo.1_Missense_Mutation_p.D250Y|ESRRG_uc001hle.1_Missense_Mutation_p.D250Y	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	273					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	AACTCTCGGTCGGCCAAGTCA	0.458													17	85					5.3912e-06	3.21171e-05	1	0	A	216737606	A	A	216737606	3	1	196	1	0	0	0	0	1	0	0	0	5286	884	31	3	571	3	ESRRG	1	216737606	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	4184269	216737606	32513015	22	36094											
TPO	7173	broad.mit.edu	37	chr2	1459959	1459959	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatacatcgaccacgacatcGcgttcacaccacagagcacc	14	5	6	16	4	1	1	1	0	0	1	3	3	1	1	3	0	2	2	3	0	2	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:1459959G>A	uc002qww.2	+	7	815	c.724G>A	c.(724-726)GCG>ACG	p.A242T	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.A242T|TPO_uc002qwr.2_Missense_Mutation_p.A242T|TPO_uc002qwx.2_Missense_Mutation_p.A242T|TPO_uc010yio.1_Missense_Mutation_p.A242T|TPO_uc010yip.1_Missense_Mutation_p.A242T	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	242	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity	p.A242A(1)		ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CCACGACATCGCGTTCACACC	0.498													7	58					0	0	0	0	A	1459959	A	A	1459959	3	1	196	1	0	0	0	0	1	0	0	0	16477	1087	38	1	746	1	TPO	2	1459959	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08		1459959	241739414	23	36095											
PXDN	7837	broad.mit.edu	37	chr2	1648500	1648500	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgagcgccggaaacaggtcGatgttgagtgtcgagccata	11	7	14	9	5	0	1	0	1	0	0	2	5	0	2	2	2	3	1	2	2	2	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:1648500G>A	uc002qxa.2	-	18	3697	c.3633C>T	c.(3631-3633)ATC>ATT	p.I1211I		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1211					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GAAACAGGTCGATGTTGAGTG	0.498													10	32					0	0	0	0	A	1648500	A	A	1648500	2	1	196	1	0	0	0	0	0	0	0	1	12912	1048	37	1		1	PXDN	2	1648500	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	188541	1648500	241550873	24	36096											
LRRTM1	347730	broad.mit.edu	37	chr2	80530510	80530510	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgcctgcagcttgttgtaCgagaggtccacgctgcgcag	7	8	14	12	4	0	1	0	0	0	1	1	2	1	1	2	1	5	6	2	1	1	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:80530510C>T	uc002sok.1	-	2	705	c.435G>A	c.(433-435)TCG>TCA	p.S145S	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	145	LRR 3.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GCTTGTTGTACGAGAGGTCCA	0.632										HNSCC(69;0.2)			13	90					0	0	0	0	T	80530510	T	T	80530510	2	4	196	1	0	0	0	0	0	0	0	1	9089	523	19	1		1	LRRTM1	2	80530510	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	78882010	80530510	162668863	25	36097											
EIF5B	9669	broad.mit.edu	37	chr2	99980764	99980764	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaagaaaaaagagaaaggAaaaagcaaaaagaaaaagaa	31	0	8	2	0	0	4	0	0	0	4	0	6	0	5	0	1	2	1	0	1	13	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:99980764A>C	uc002tab.2	+	6	1352	c.1168A>C	c.(1168-1170)AAA>CAA	p.K390Q		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	390					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						aagagaaaggaaaaagcaaaa	0.274													11	104					0	0	0	0	C	99980764	C	C	99980764	3	2	196	1	0	0	0	0	1	0	0	0	5068	247	9	5	1190	5	EIF5B	2	99980764	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	19450254	99980764	143218609	26	36098											
CCDC74A	90557	broad.mit.edu	37	chr2	132290462	132290462	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacctcaagtccctcctggAagggagccagaggccccagg	9	4	13	15	0	1	1	1	0	0	1	3	3	3	3	6	4	1	1	6	4	2	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:132290462A>G	uc002tta.2	+	6	954	c.902A>G	c.(901-903)GAA>GGA	p.E301G	CCDC74A_uc002ttb.2_Missense_Mutation_p.E235G	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	301										skin(1)	1						TCCCTCCTGGAAGGGAGCCAG	0.692													13	56					0	0	0	0	G	132290462	G	G	132290462	3	3	196	1	0	0	0	0	1	0	0	0	2860	246	9	5	924	5	CCDC74A	2	132290462	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	32309698	132290462	110908911	27	36099											
LRP1B	53353	broad.mit.edu	37	chr2	141260621	141260621	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actgccattgagtatttagaAgacaccgcccatcagcacaa	14	8	7	12	1	1	3	1	1	0	2	1	3	1	3	3	0	2	2	3	0	4	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:141260621A>G	uc002tvj.1	-	54	9545	c.8573T>C	c.(8572-8574)CTT>CCT	p.L2858P		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2858	Extracellular (Potential).|LDL-receptor class A 19.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGTATTTAGAAGACACCGCCC	0.388										TSP Lung(27;0.18)			19	71					0	0	0	0	G	141260621	G	G	141260621	3	3	196	1	0	0	0	0	1	0	0	0	9005	72	3	5	5378	5	LRP1B	2	141260621	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	8970159	141260621	101938752	28	36100											
UPP2	151531	broad.mit.edu	37	chr2	158991382	158991382	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccaacttcatcagacggCggcttggactttgtgactag	8	12	10	11	2	3	2	2	1	1	1	4	3	3	3	1	3	1	1	1	3	2	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:158991382C>T	uc002tzp.2	+	7	1128	c.934C>T	c.(934-936)CGG>TGG	p.R312W	UPP2_uc002tzo.2_Missense_Mutation_p.R369W	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	312					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						CATCAGACGGCGGCTTGGACT	0.493													8	90					0	0	0	0	T	158991382	T	T	158991382	3	4	196	1	0	0	0	0	1	0	0	0	17081	759	27	1	1139	1	UPP2	2	158991382	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	17730761	158991382	84207991	29	36101											
B3GALT1	8708	broad.mit.edu	37	chr2	168725997	168725997	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggactttattgactcctacCataaccttaccctcaaaaca	14	11	3	13	0	1	1	1	1	0	0	2	2	2	2	4	1	4	0	4	1	6	6			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:168725997C>A	uc002udz.1	+	2	799	c.448C>A	c.(448-450)CAT>AAT	p.H150N		NM_020981	NP_066191	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta	150	Lumenal (Potential).				lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4						TGACTCCTACCATAACCTTAC	0.428													9	51					0.000274275	0.00154894	1	0	A	168725997	A	A	168725997	3	1	196	1	0	0	0	0	1	0	0	0	1249	594	21	4	450	4	B3GALT1	2	168725997	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	9734615	168725997	74473376	30	36102											
TTN	7273	broad.mit.edu	37	chr2	179620992	179620992	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgttgtcctctctccacaGtcattgtgtacaatgcagct	8	13	8	12	1	2	0	1	0	1	0	5	1	4	0	2	0	3	4	2	0	2	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:179620992G>C	uc010zfh.1	-	44	10922	c.10698C>G	c.(10696-10698)GAC>GAG	p.D3566E	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc002unb.2_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	3580							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCTCCACAGTCATTGTGTA	0.388													32	111					0	0	0	0	C	179620992	C	C	179620992	3	2	196	1	0	0	0	0	1	0	0	0	16803	1020	36	4	100045	4	TTN	2	179620992	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	10894995	179620992	63578381	31	36103											
CCDC108	255101	broad.mit.edu	37	chr2	219895483	219895485	+	In_Frame_Del	DEL	CTT	-	-																															acagagccaaagtacaacagCttctggaagccctcggcatc																										TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:219895483_219895485delCTT	uc002vjl.1	-	9	1171_1173	c.1087_1089delAAG	c.(1087-1089)AAGdel	p.K363del	CCDC108_uc010fwa.1_5'Flank|CCDC108_uc010zkp.1_In_Frame_Del_p.K352del|CCDC108_uc010zkq.1_In_Frame_Del_p.K298del	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	363						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGTACAACAGCTTCTGGAAGCCC	0.64													---	---	---								-	219895485	-	-	219895483	7	5	196	1	0	1	0	1	0	0	0	0	2755	796	28	0	4796	0	CCDC108	2	219895483	In_Frame_Del	DEL	CTT	TCGA-CV-6937-01A-11D-2012-08	40274491	219895483	23303890	32	36104											
SH3BP4	23677	broad.mit.edu	37	chr2	235950011	235950011	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctttttgacgcaggtacaTcctccttcaccgaatccagc	8	12	6	15	2	1	1	1	1	0	0	5	2	5	1	5	1	2	2	5	1	2	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:235950011T>A	uc002vvp.2	+	4	991	c.598T>A	c.(598-600)TCC>ACC	p.S200T	SH3BP4_uc010fym.2_Missense_Mutation_p.S200T|SH3BP4_uc002vvq.2_Missense_Mutation_p.S200T	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	200					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CGCAGGTACATCCTCCTTCAC	0.537													31	88					0	0	0	0	A	235950011	A	A	235950011	3	1	196	1	0	0	0	0	1	0	0	0	14311	1435	50	5	604	5	SH3BP4	2	235950011	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	16054528	235950011	7249362	33	36105											
ANO7	50636	broad.mit.edu	37	chr2	242162677	242162677	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccatccgcctggccttcGtcattgtgtttgaggtagcc	4	14	11	12	2	1	1	1	1	0	0	3	1	2	1	5	2	2	2	5	2	1	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr2:242162677G>A	uc002wax.2	+	22	2663	c.2560G>A	c.(2560-2562)GTC>ATC	p.V854I		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	854	Helical; (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CCTGGCCTTCGTCATTGTGTT	0.567													44	134					0	0	0	0	A	242162677	A	A	242162677	3	1	196	1	0	0	0	0	1	0	0	0	702	1145	40	1	2718	1	ANO7	2	242162677	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	6212666	242162677	1036696	34	36106											
TRANK1	9881	broad.mit.edu	37	chr3	36897578	36897578	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggccttggtggacttggaaAgctcaatgaaattcctttgt	9	14	11	7	0	1	1	1	1	0	0	2	3	2	3	2	4	1	1	2	4	3	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:36897578A>G	uc003cgj.2	-	3	2155	c.1853T>C	c.(1852-1854)CTT>CCT	p.L618P		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1168					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GGACTTGGAAAGCTCAATGAA	0.483													37	115					0	0	0	0	G	36897578	G	G	36897578	3	3	196	1	0	0	0	0	1	0	0	0	16521	72	3	5	5322	5	TRANK1	3	36897578	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08		36897578	161124852	35	36107											
MST1	4485	broad.mit.edu	37	chr3	49721591	49721591	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccaggacccagcagttgtggGtaaagcaggcaagtgggccc	10	5	15	11	0	0	0	0	0	0	0	0	1	0	1	3	4	2	5	3	4	3	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:49721591G>A	uc003cxg.2	-	18	2120	c.2048C>T	c.(2047-2049)ACC>ATC	p.T683I		NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	669	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCAGTTGTGGGTAAAGCAGGC	0.562													8	36					0	0	0	0	A	49721591	A	A	49721591	3	1	196	1	0	0	0	0	1	0	0	0	9943	1261	44	4	133	4	MST1	3	49721591	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	12824013	49721591	148300839	36	36108											
EPHA3	2042	broad.mit.edu	37	chr3	89521703	89521703	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatggtgtctggacagcacActgcaaggaaatcttcacgg	12	9	11	9	1	3	0	1	0	2	0	3	2	3	2	0	4	2	2	0	4	3	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:89521703A>T	uc003dqy.2	+	16	3005	c.2780A>T	c.(2779-2781)CAC>CTC	p.H927L	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	927	Cytoplasmic (Potential).|SAM.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGGACAGCACACTGCAAGGAA	0.428										TSP Lung(6;0.00050)			16	149					0	0	0	0	T	89521703	T	T	89521703	3	4	196	1	0	0	0	0	1	0	0	0	5192	159	6	5	2868	5	EPHA3	3	89521703	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	39800112	89521703	108500727	37	36109											
BOC	91653	broad.mit.edu	37	chr3	112991529	112991529	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccggggcagcggtcatcCtctacaatgtccaggtgttt	7	10	12	12	2	2	0	1	0	1	0	4	0	4	0	3	4	3	2	3	4	2	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:112991529C>G	uc003dzx.2	+	7	1561	c.940C>G	c.(940-942)CTC>GTC	p.L314V	BOC_uc003dzy.2_Missense_Mutation_p.L314V|BOC_uc003dzz.2_Missense_Mutation_p.L314V|BOC_uc003eab.2_Missense_Mutation_p.L15V	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	314	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			AGCGGTCATCCTCTACAATGT	0.582													7	41					0	0	0	0	G	112991529	G	G	112991529	3	3	196	1	0	0	0	0	1	0	0	0	1484	681	24	4	958	4	BOC	3	112991529	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	23469826	112991529	85030901	38	36110											
C3orf15	89876	broad.mit.edu	37	chr3	119459395	119459395	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgatttgatttgatacaGatgtttgaagggaaagaaaa	15	14	10	2	0	0	6	0	4	0	2	0	7	0	7	0	1	1	1	0	1	5	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:119459395G>T	uc003ede.3	+	13	1611	c.1534_splice	c.e13-1	p.M512_splice	C3orf15_uc010hqy.1_Splice_Site_p.M512_splice|C3orf15_uc010hqz.2_Splice_Site_p.M450_splice|C3orf15_uc011bjd.1_Splice_Site_p.M386_splice|C3orf15_uc011bje.1_Splice_Site_p.M492_splice|C3orf15_uc010hra.1_Splice_Site_p.M273_splice	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha							mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		ATTTGATACAGATGTTTGAAG	0.468													11	75					9.31168e-06	5.44761e-05	1	0	T	119459395	T	T	119459395	5	4	196	1	0	0	0	0	0	0	1	0	2219	956	33	2	1583	2	C3orf15	3	119459395	Splice_Site	SNP	G	TCGA-CV-6937-01A-11D-2012-08	6467866	119459395	78563035	39	36111											
GOLGB1	2804	broad.mit.edu	37	chr3	121409852	121409852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtttcagaaagaagagcatCtctctctctgtttaagagtc	11	13	9	8	0	4	4	1	0	3	4	7	4	4	4	0	1	1	3	0	1	3	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:121409852C>T	uc003eei.3	-	14	8470	c.8344G>A	c.(8344-8346)GAT>AAT	p.D2782N	GOLGB1_uc010hrc.2_Missense_Mutation_p.D2787N|GOLGB1_uc003eej.3_Missense_Mutation_p.D2748N	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2782	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AGAAGAGCATCTCTCTCTCTG	0.418													7	76					0	0	0	0	T	121409852	T	T	121409852	3	4	196	1	0	0	0	0	1	0	0	0	6602	913	32	2	1471	2	GOLGB1	3	121409852	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	1950457	121409852	76612578	40	36112											
C3orf37	56941	broad.mit.edu	37	chr3	129009622	129009622	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaggcagccatacttcatctAttttcctcaaatcaagacag	13	11	6	11	0	4	1	3	0	1	1	5	2	5	1	2	1	2	1	2	1	4	5	rs142370950		TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:129009622A>G	uc003elt.2	+	4	516	c.428A>G	c.(427-429)TAT>TGT	p.Y143C	C3orf37_uc003elu.2_Intron|C3orf37_uc003elv.2_Missense_Mutation_p.Y143C|C3orf37_uc003elw.2_Missense_Mutation_p.Y143C	NM_020187	NP_064572	Q96FZ2	CC037_HUMAN	hypothetical protein LOC56941	143										ovary(1)	1						TACTTCATCTATTTTCCTCAA	0.413													11	73					0	0	0	0	G	129009622	G	G	129009622	3	3	196	1	0	0	0	0	1	0	0	0	2237	449	16	5	438	5	C3orf37	3	129009622	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	7599770	129009622	69012808	41	36113											
CEP63	80254	broad.mit.edu	37	chr3	134278043	134278043	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataaagactgagcactacaaAacagatcttcattctccaag	17	9	5	10	0	3	3	1	1	2	2	4	3	3	3	1	0	3	1	1	0	6	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:134278043A>C	uc003eqo.1	+	15	2174	c.1725A>C	c.(1723-1725)AAA>AAC	p.K575N	CEP63_uc003eql.1_Intron|CEP63_uc003eqm.2_Intron|CEP63_uc003eqn.1_Intron	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	575					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						AGCACTACAAAACAGATCTTC	0.443													53	168					0	0	0	0	C	134278043	C	C	134278043	3	2	196	1	0	0	0	0	1	0	0	0	3272	11	1	5	1775	5	CEP63	3	134278043	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	5268421	134278043	63744387	42	36114											
ATR	545	broad.mit.edu	37	chr3	142180856	142180856	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccattcaataatcccacatTcatcatttagtggaataact	14	13	3	11	0	3	0	3	0	0	0	4	1	4	1	2	1	1	0	2	1	5	6			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:142180856T>A	uc003eux.3	-	42	7240	c.7118A>T	c.(7117-7119)GAA>GTA	p.E2373V	ATR_uc003euy.1_Missense_Mutation_p.E259V	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2373	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						AATCCCACATTCATCATTTAG	0.313								Other_conserved_DNA_damage_response_genes					47	189					0	0	0	0	A	142180856	A	A	142180856	3	1	196	1	0	0	0	0	1	0	0	0	1206	1783	62	5	840	5	ATR	3	142180856	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	7902813	142180856	55841574	43	36115											
LRRC15	131578	broad.mit.edu	37	chr3	194080176	194080176	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcccgctctgggcctgggTcatgccccaaacgctgcggt	5	7	13	16	3	2	0	1	0	1	0	2	0	2	0	4	3	4	2	4	3	1	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:194080176T>C	uc003ftu.2	-	2	1683	c.1597A>G	c.(1597-1599)ACC>GCC	p.T533A	LRRC15_uc003ftt.2_Missense_Mutation_p.T539A	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	533	Extracellular (Potential).					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TGGGCCTGGGTCATGCCCCAA	0.587													5	113					0	0	0	0	C	194080176	C	C	194080176	3	2	196	1	0	0	0	0	1	0	0	0	9020	1667	58	5	152	5	LRRC15	3	194080176	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	51899320	194080176	3942254	44	36116											
MFI2	4241	broad.mit.edu	37	chr3	196753556	196753556	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtacacttcgcccaccacCggcttcaggccgtgctcctt	5	10	8	18	4	1	0	1	0	0	0	4	0	2	0	5	2	2	3	5	2	1	4	rs138189044		TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr3:196753556C>T	uc003fxk.3	-	3	392	c.279G>A	c.(277-279)CCG>CCA	p.P93P	MFI2_uc003fxl.3_Silent_p.P93P|MFI2_uc011bua.1_Silent_p.P93P	NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	93	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		CGCCCACCACCGGCTTCAGGC	0.617													9	124					0	0	0	0	T	196753556	T	T	196753556	2	4	196	1	0	0	0	0	0	0	0	1	9575	639	23	1		1	MFI2	3	196753556	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	2673380	196753556	1268874	45	36117											
IDUA	3425	broad.mit.edu	37	chr4	996204	996204	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgcttccaggtcaacaacAcccgcccgccgcacgtgcag	8	4	10	19	6	1	0	1	0	0	0	2	0	2	0	4	1	3	3	4	1	2	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr4:996204A>C	uc003gby.2	+	8	1208	c.1120A>C	c.(1120-1122)ACC>CCC	p.T374P	IDUA_uc003gbz.2_RNA|IDUA_uc003gca.2_Missense_Mutation_p.T396P	NM_000203	NP_000194	P35475	IDUA_HUMAN	alpha-L-iduronidase precursor	374					disaccharide metabolic process	lysosome	cation binding|L-iduronidase activity				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)		Laronidase(DB00090)	GGTCAACAACACCCGCCCGCC	0.711													4	5					0	0	0	0	C	996204	C	C	996204	3	2	196	1	0	0	0	0	1	0	0	0	7543	159	6	5	1150	5	IDUA	4	996204	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08		996204	190158072	46	36118											
C4orf23	152992	broad.mit.edu	37	chr4	8472843	8472843	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggcagaagtagccaacgagCtggacacggagaccctgcgg	11	4	15	11	3	0	2	0	0	0	2	0	5	0	3	2	4	4	3	2	4	3	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr4:8472843C>T	uc003glg.1	+	10	1461	c.1273C>T	c.(1273-1275)CTG>TTG	p.L425L	C4orf23_uc003glh.1_Silent_p.L262L|C4orf23_uc003gli.1_5'Flank	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	654					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						AGCCAACGAGCTGGACACGGA	0.557													24	212					0	0	0	0	T	8472843	T	T	8472843	2	4	196	1	0	0	0	0	0	0	0	1	2266	796	28	4		4	C4orf23	4	8472843	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	7476639	8472843	182681433	47	36119											
BOD1L	259282	broad.mit.edu	37	chr4	13603427	13603427	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcactgcttatagatccTgctcttatctctgttccagc	6	17	5	13	0	4	1	1	0	3	1	7	1	6	1	2	0	3	3	2	0	3	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr4:13603427T>C	uc003gmz.1	-	10	5214	c.5097A>G	c.(5095-5097)GCA>GCG	p.A1699A	BOD1L_uc010idr.1_Silent_p.A1036A	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1699							DNA binding			ovary(5)|breast(1)	6						TTATAGATCCTGCTCTTATCT	0.418													38	388					0	0	0	0	C	13603427	C	C	13603427	2	2	196	1	0	0	0	0	0	0	0	1	1486	1567	55	5		5	BOD1L	4	13603427	Silent	SNP	T	TCGA-CV-6937-01A-11D-2012-08	5130584	13603427	177550849	48	36120											
RFC1	5981	broad.mit.edu	37	chr4	39308288	39308288	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acgctgctttaaaactagagCcatcatctttgccggaaaat	13	11	7	10	2	2	1	1	0	1	1	2	2	2	2	2	1	4	2	2	1	5	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr4:39308288C>A	uc003gty.1	-	14	2056	c.1922G>T	c.(1921-1923)GGC>GTC	p.G641V	RFC1_uc003gtx.1_Missense_Mutation_p.G640V	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	641				G -> N (in Ref. 2, 3 and 4).	DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						AAAACTAGAGCCATCATCTTT	0.473													5	47					3.59834e-05	0.00020926	1	0	A	39308288	A	A	39308288	3	1	196	1	0	0	0	0	1	0	0	0	13309	739	26	4	1572	4	RFC1	4	39308288	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	25704861	39308288	151845988	49	36121											
UGT2B4	7363	broad.mit.edu	37	chr4	70346487	70346487	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagagtggtactggaaccaGgtgaggtcgtgggctgcaac	11	7	16	7	1	0	2	0	1	0	1	1	3	0	3	1	5	4	3	1	5	4	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr4:70346487G>A	uc003hek.3	-	6	1499	c.1452C>T	c.(1450-1452)ACC>ACT	p.T484T	UGT2B4_uc011cap.1_Silent_p.T348T|UGT2B4_uc003hel.3_3'UTR	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	484					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						ACTGGAACCAGGTGAGGTCGT	0.498													35	169					0	0	0	0	A	70346487	A	A	70346487	2	1	196	1	0	0	0	0	0	0	0	1	17029	987	35	4		4	UGT2B4	4	70346487	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	31038199	70346487	120807789	50	36122											
C4orf17	84103	broad.mit.edu	37	chr4	100451030	100451030	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcatgctctactcctggctCctgttcttcagggatgacaa	7	12	10	12	0	3	1	1	1	2	0	5	2	5	2	2	3	2	4	2	3	2	3	rs145411536	byFrequency	TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr4:100451030C>T	uc003huw.2	+	5	784	c.461C>T	c.(460-462)TCC>TTC	p.S154F	C4orf17_uc003hux.2_RNA	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	hypothetical protein LOC84103	154											0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		ACTCCTGGCTCCTGTTCTTCA	0.378													15	41					0	0	0	0	T	100451030	T	T	100451030	3	4	196	1	0	0	0	0	1	0	0	0	2262	855	30	2	475	2	C4orf17	4	100451030	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	30104543	100451030	90703246	51	36123											
ANK2	287	broad.mit.edu	37	chr4	114257135	114257135	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcccagaaggaggtgtactGagcagcacagtggtgcccca	10	5	15	11	0	0	2	0	1	0	1	0	3	0	3	3	4	4	3	3	4	2	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr4:114257135G>A	uc003ibe.3	+	30	3613	c.3513G>A	c.(3511-3513)CTG>CTA	p.L1171L	ANK2_uc003ibd.3_Silent_p.L1162L|ANK2_uc003ibf.3_Silent_p.L1171L|ANK2_uc011cgc.1_Silent_p.L347L|ANK2_uc003ibg.3_Silent_p.L166L|ANK2_uc003ibc.2_Silent_p.L1147L|ANK2_uc011cgb.1_Silent_p.L1186L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1138					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAGGTGTACTGAGCAGCACAG	0.567													11	90					0	0	0	0	A	114257135	A	A	114257135	2	1	196	1	0	0	0	0	0	0	0	1	621	1277	45	2		2	ANK2	4	114257135	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	13806105	114257135	76897141	52	36124											
PCDH18	54510	broad.mit.edu	37	chr4	138451748	138451748	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagatggtgtatgtcacttGcccattttctccaagatcag	10	13	8	10	0	3	2	2	0	1	2	4	2	3	2	2	1	1	1	2	1	3	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr4:138451748G>T	uc003ihe.3	-	1	1882	c.1495C>A	c.(1495-1497)CAA>AAA	p.Q499K	PCDH18_uc003ihf.3_Missense_Mutation_p.Q492K|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.Q279K|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	499	Extracellular (Potential).|Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TATGTCACTTGCCCATTTTCT	0.408													17	135					1.02788e-11	6.23753e-11	1	0	T	138451748	T	T	138451748	3	4	196	1	0	0	0	0	1	0	0	0	11567	1328	46	4	1928	4	PCDH18	4	138451748	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	24194613	138451748	52702528	53	36125											
CDH10	1008	broad.mit.edu	37	chr5	24505329	24505329	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaatgttaaagattctgtCaaggtcagtatggcgatcca	13	12	10	6	1	3	2	2	1	1	1	4	3	4	2	1	2	0	2	1	2	5	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:24505329C>T	uc003jgr.1	-	8	1617	c.1285G>A	c.(1285-1287)GAC>AAC	p.D429N	CDH10_uc011cnu.1_Intron	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	429	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AAGATTCTGTCAAGGTCAGTA	0.368										HNSCC(23;0.051)			4	44					0	0	0	0	T	24505329	T	T	24505329	3	4	196	1	0	0	0	0	1	0	0	0	3111	826	29	2	1101	2	CDH10	5	24505329	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08		24505329	156409931	54	36126											
AMACR	23600	broad.mit.edu	37	chr5	33998863	33998863	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atccaacatgttctgtcctcGaggtgcttcccacagactca	9	11	7	14	1	2	1	1	0	1	1	6	2	5	1	3	1	2	2	3	1	1	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:33998863G>C	uc003jig.2	-	4	704	c.622C>G	c.(622-624)CGA>GGA	p.R208G	AMACR_uc003jih.2_Missense_Mutation_p.S154W|AMACR_uc003jii.2_Missense_Mutation_p.R193G|AMACR_uc003jij.2_Missense_Mutation_p.R208G|AMACR_uc003jil.1_Missense_Mutation_p.R208G|AMACR_uc003jik.1_Missense_Mutation_p.S154W	NM_014324	NP_055139	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase isoform 1	208					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity				0						TTCTGTCCTCGAGGTGCTTCC	0.433													6	120					0	0	0	0	C	33998863	C	C	33998863	3	2	196	1	0	0	0	0	1	0	0	0	562	1068	37	3	864	3	AMACR	5	33998863	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	9493534	33998863	146916397	55	36127											
MRPS30	10884	broad.mit.edu	37	chr5	44809264	44809264	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggcggatcgagcgctggcAggcgacggtgcacgctgcgg	5	4	20	12	8	0	0	0	0	0	0	1	3	0	1	0	6	3	4	0	6	0	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:44809264A>T	uc003joh.2	+	1	238	c.200A>T	c.(199-201)CAG>CTG	p.Q67L	MRPS30_uc003joi.1_5'Flank	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	67					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					GAGCGCTGGCAGGCGACGGTG	0.637													12	34					0	0	0	0	T	44809264	T	T	44809264	3	4	196	1	0	0	0	0	1	0	0	0	9893	188	7	5	202	5	MRPS30	5	44809264	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	10810401	44809264	136105996	56	36128											
ACTBL2	345651	broad.mit.edu	37	chr5	56777772	56777772	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcttcagggcatcggaagcGttcattcccaatggtgatca	9	10	12	10	2	3	1	3	1	0	0	5	2	4	2	1	4	1	3	1	4	2	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:56777772G>A	uc003jrm.2	-	1	865	c.763C>T	c.(763-765)CGC>TGC	p.R255C		NM_001017992	NP_001017992	Q562R1	ACTBL_HUMAN	actin, beta-like 2	255						cytoplasm|cytoskeleton	ATP binding			ovary(3)	3		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		CATCGGAAGCGTTCATTCCCA	0.532													9	51					0	0	0	0	A	56777772	A	A	56777772	3	1	196	1	0	0	0	0	1	0	0	0	194	1145	40	1	371	1	ACTBL2	5	56777772	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	11968508	56777772	124137488	57	36129											
HTR1A	3350	broad.mit.edu	37	chr5	63256301	63256301	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggcggcagaacttacactTaatgatcttcttaaacgcgt	11	12	8	10	3	2	2	0	1	2	1	2	2	2	2	0	2	3	1	0	2	5	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:63256301T>C	uc011cqt.1	-	1	1246	c.1246A>G	c.(1246-1248)AAG>GAG	p.K416E		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	416	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AACTTACACTTAATGATCTTC	0.498													31	247					0	0	0	0	C	63256301	C	C	63256301	3	2	196	1	0	0	0	0	1	0	0	0	7475	1763	61	5	25	5	HTR1A	5	63256301	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	6478529	63256301	117658959	58	36130											
LYSMD3	116068	broad.mit.edu	37	chr5	89821073	89821073	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttgactgaactcctggaaGaggaaaactacgattctgat	14	10	9	8	1	1	4	0	3	1	1	2	7	2	6	1	2	3	0	1	2	5	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:89821073G>A	uc003kjr.2	-	2	182	c.34C>T	c.(34-36)CTT>TTT	p.L12F	LYSMD3_uc010jaz.1_Missense_Mutation_p.L12F|LYSMD3_uc003kjs.1_Missense_Mutation_p.L12F	NM_198273	NP_938014	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain	12	Extracellular (Potential).				cell wall macromolecule catabolic process	integral to membrane					0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		ACTCCTGGAAGAGGAAAACTA	0.403													4	48					0	0	0	0	A	89821073	A	A	89821073	3	1	196	1	0	0	0	0	1	0	0	0	9177	942	33	2	894	2	LYSMD3	5	89821073	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	26564772	89821073	91094187	59	36131											
GIN1	54826	broad.mit.edu	37	chr5	102442428	102442428	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cataagccatacccactgttTgacatcattggtcacagatg	12	11	7	11	0	2	2	2	1	0	1	2	2	2	2	2	1	2	1	2	1	2	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:102442428T>G	uc003koa.1	-	3	407	c.325A>C	c.(325-327)AAA>CAA	p.K109Q	GIN1_uc003kob.1_Intron|GIN1_uc003koc.1_Missense_Mutation_p.K109Q	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	109					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		ACCCACTGTTTGACATCATTG	0.353													4	27					0	0	0	0	G	102442428	G	G	102442428	3	3	196	1	0	0	0	0	1	0	0	0	6423	1821	63	5	1267	5	GIN1	5	102442428	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	12621355	102442428	78472832	60	36132											
PJA2	9867	broad.mit.edu	37	chr5	108714181	108714181	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttctttgtttcgcctcaTgcctattaaaacctgtttct	7	18	4	12	1	3	0	1	0	2	0	4	0	3	0	3	0	2	2	3	0	3	6			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:108714181T>C	uc003kos.3	-	4	1227	c.1007A>G	c.(1006-1008)CAT>CGT	p.H336R		NM_014819	NP_055634	O43164	PJA2_HUMAN	praja 2, RING-H2 motif containing	336					long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		TTTCGCCTCATGCCTATTAAA	0.408													49	208					0	0	0	0	C	108714181	C	C	108714181	3	2	196	1	0	0	0	0	1	0	0	0	12017	1464	51	5	1147	5	PJA2	5	108714181	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	6271753	108714181	72201079	61	36133											
KCNN2	3781	broad.mit.edu	37	chr5	113740539	113740539	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ataattgccgcatggactgtCcgagcttgtgaaaggtaagt	11	11	12	7	2	0	1	0	1	0	0	1	3	1	2	2	2	2	3	2	2	3	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:113740539C>T	uc003kqo.2	+	3	1444	c.987C>T	c.(985-987)GTC>GTT	p.V329V		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	329						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CATGGACTGTCCGAGCTTGTG	0.348													26	174					0	0	0	0	T	113740539	T	T	113740539	2	4	196	1	0	0	0	0	0	0	0	1	8118	842	30	2		2	KCNN2	5	113740539	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	5026358	113740539	67174721	62	36134											
PCDHA13	56136	broad.mit.edu	37	chr5	140263296	140263296	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcacggtgtctgctcaggaCgcggacgcacaggagaacgc	9	6	14	12	5	3	1	2	0	1	1	3	4	3	3	0	4	2	2	0	4	1	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:140263296C>T	uc003lif.2	+	1	1443	c.1443C>T	c.(1441-1443)GAC>GAT	p.D481D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.D481D|PCDHA13_uc003lid.2_Silent_p.D481D	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	481	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCTCAGGACGCGGACGCAC	0.662													34	137					0	0	0	0	T	140263296	T	T	140263296	2	4	196	1	0	0	0	0	0	0	0	1	11577	535	19	1		1	PCDHA13	5	140263296	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	26522757	140263296	40651964	63	36135											
PCDHA13	56136	broad.mit.edu	37	chr5	140263844	140263844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcgctgacggccacggcaaCggtgctgttgtcgctggtgg	4	8	17	12	6	0	1	0	1	0	0	1	1	0	1	1	5	2	5	1	5	1	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:140263844C>T	uc003lif.2	+	1	1991	c.1991C>T	c.(1990-1992)ACG>ATG	p.T664M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.T664M|PCDHA13_uc003lid.2_Missense_Mutation_p.T664M	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	664	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACGGCAACGGTGCTGTTG	0.687													26	111					0	0	0	0	T	140263844	T	T	140263844	3	4	196	1	0	0	0	0	1	0	0	0	11577	536	19	1	1993	1	PCDHA13	5	140263844	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	548	140263844	40651416	64	36136											
RBM27	54439	broad.mit.edu	37	chr5	145609363	145609363	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaattgtaccgtgagaagtAtgactggagaagaggcagga	14	8	15	4	1	0	5	0	3	0	3	0	8	0	6	1	3	1	3	1	3	5	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:145609363A>G	uc003lnz.3	+	5	645	c.479A>G	c.(478-480)TAT>TGT	p.Y160C	RBM27_uc003lny.2_Missense_Mutation_p.Y160C	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	160	Arg-rich.				mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGTGAGAAGTATGACTGGAGA	0.413													71	104					0	0	0	0	G	145609363	G	G	145609363	3	3	196	1	0	0	0	0	1	0	0	0	13192	449	16	5	497	5	RBM27	5	145609363	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	5345519	145609363	35305897	65	36137											
EBF1	1879	broad.mit.edu	37	chr5	158140094	158140094	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagggccgggagttggttgTggttgcggggaacactgtac	7	9	18	7	2	0	0	0	0	0	0	0	2	0	2	1	6	3	4	1	6	3	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:158140094T>A	uc010jip.2	-	13	1555	c.1253A>T	c.(1252-1254)CAC>CTC	p.H418L	EBF1_uc011ddw.1_Missense_Mutation_p.H286L|EBF1_uc011ddx.1_Missense_Mutation_p.H419L|EBF1_uc003lxl.3_Missense_Mutation_p.H387L	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	418					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAGTTGGTTGTGGTTGCGGGG	0.562			T	HMGA2	lipoma								24	45					0	0	0	0	A	158140094	A	A	158140094	3	1	196	1	0	0	0	0	1	0	0	0	4902	1696	59	5	538	5	EBF1	5	158140094	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	12530731	158140094	22775166	66	36138											
GABRA1	2554	broad.mit.edu	37	chr5	161324318	161324318	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtgtcagcaaaattgacCgactgtcaagaatagccttc	14	9	8	10	1	2	2	2	1	0	1	3	3	2	2	2	0	2	1	2	0	5	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr5:161324318C>T	uc010jiw.2	+	11	1729	c.1261C>T	c.(1261-1263)CGA>TGA	p.R421*	GABRA1_uc010jix.2_Nonsense_Mutation_p.R421*|GABRA1_uc010jiy.2_Nonsense_Mutation_p.R421*|GABRA1_uc003lyx.3_Nonsense_Mutation_p.R421*|GABRA1_uc010jiz.2_Nonsense_Mutation_p.R421*|GABRA1_uc010jja.2_Nonsense_Mutation_p.R421*|GABRA1_uc010jjb.2_Nonsense_Mutation_p.R421*	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	421	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CAAAATTGACCGACTGTCAAG	0.443													48	172					0	0	0	0	T	161324318	T	T	161324318	4	4	196	1	0	0	0	0	0	1	0	0	6194	644	23	1	1295	1	GABRA1	5	161324318	Nonsense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	3184224	161324318	19590942	67	36139											
HIST1H4E	8367	broad.mit.edu	37	chr6	26205156	26205156	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctacgcgctgaagagacaggGacgcactctttacggcttcg	9	8	12	12	5	1	2	0	1	1	1	2	4	1	3	0	2	2	3	0	2	3	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr6:26205156G>A	uc003ngy.2	+	1	284	c.284G>A	c.(283-285)GGA>GAA	p.G95E		NM_003545	NP_003536	P62805	H4_HUMAN	histone cluster 1, H4e	95					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				AAGAGACAGGGACGCACTCTT	0.527													16	60					0	0	0	0	A	26205156	A	A	26205156	3	1	196	1	0	0	0	0	1	0	0	0	7208	1174	41	2	286	2	HIST1H4E	6	26205156	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08		26205156	144909911	68	36140											
HLA-A	3105	broad.mit.edu	37	chr6	29911172	29911172	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aacgaggacctgcgctcttgGaccgcggcggacatggcggc	7	5	16	13	6	1	0	0	0	1	0	1	4	1	3	2	6	2	1	2	6	1	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr6:29911172G>A	uc003nol.2	+	3	471	c.471G>A	c.(469-471)TGG>TGA	p.W157*	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_RNA|HLA-A_uc010jrq.2_Nonsense_Mutation_p.W36*|HLA-A_uc003nok.2_Nonsense_Mutation_p.W36*|HLA-A_uc003non.2_Nonsense_Mutation_p.W157*|HLA-A_uc003noo.2_Nonsense_Mutation_p.W157*|HLA-A_uc010jrr.2_Nonsense_Mutation_p.W157*|HLA-A_uc003nom.2_Nonsense_Mutation_p.W36*|HLA-A_uc010klp.2_Nonsense_Mutation_p.W129*|HLA-A_uc011dmc.1_Nonsense_Mutation_p.W36*|HLA-A_uc011dmd.1_Nonsense_Mutation_p.W36*	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	157	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TGCGCTCTTGGACCGCGGCGG	0.672									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			9	32					0	0	0	0	A	29911172	A	A	29911172	4	1	196	1	0	0	0	0	0	1	0	0	7234	1183	41	2	481	2	HLA-A	6	29911172	Nonsense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	3706016	29911172	141203895	69	36141											
IP6K3	117283	broad.mit.edu	37	chr6	33703227	33703227	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgcctgccctcatgtccccGgcgtctgcgctgttttgcac	3	11	10	17	4	2	0	1	0	1	0	3	0	3	0	4	1	3	3	4	1	0	2	rs150212654		TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr6:33703227G>A	uc010jvf.2	-	3	563	c.27C>T	c.(25-27)GCC>GCT	p.A9A	IP6K3_uc003ofb.2_Silent_p.A9A	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	9					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						TCATGTCCCCGGCGTCTGCGC	0.617													6	42					0	0	0	0	A	33703227	A	A	33703227	2	1	196	1	0	0	0	0	0	0	0	1	7829	1103	39	1		1	IP6K3	6	33703227	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	3792055	33703227	137411840	70	36142											
FTSJD2	23070	broad.mit.edu	37	chr6	37426517	37426527	+	Frame_Shift_Del	DEL	AAGGGCCCTAA	-	-																															agggctttggaatgactttgAagggccctaatgacttcaag																										TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr6:37426517_37426527delAAGGGCCCTAA	uc003ons.2	+	9	1160_1170	c.907_917delAAGGGCCCTAA	c.(907-918)AAGGGCCCTAATfs	p.K303fs	FTSJD2_uc010jwu.2_Frame_Shift_Del_p.K247fs	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	303_306					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						AATGACTTTGAAGGGCCCTAATGACTTCAAG	0.512													---	---	---								-	37426527	-	-	37426517	7	5	196	1	0	1	0	1	0	0	0	0	6125	247	9	0	937	0	FTSJD2	6	37426517	Frame_Shift_Del	DEL	AAGGGCCCTAA	TCGA-CV-6937-01A-11D-2012-08	3723290	37426517	133688550	71	36143											
DOPEY1	23033	broad.mit.edu	37	chr6	83835435	83835435	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcagaacaattcagtcaaaGagtgggaagacaaaaaggta	19	5	12	5	0	2	3	2	0	0	3	2	4	2	4	0	3	1	2	0	3	7	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr6:83835435G>A	uc003pjs.1	+	15	1962	c.1702G>A	c.(1702-1704)GAG>AAG	p.E568K	DOPEY1_uc011dyy.1_Missense_Mutation_p.E559K|DOPEY1_uc010kbl.1_Missense_Mutation_p.E559K	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	568					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTCAGTCAAAGAGTGGGAAGA	0.368													9	58					0	0	0	0	A	83835435	A	A	83835435	3	1	196	1	0	0	0	0	1	0	0	0	4729	943	33	2	1752	2	DOPEY1	6	83835435	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	46408918	83835435	87279632	72	36144											
C6orf186	728464	broad.mit.edu	37	chr6	110636640	110636640	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagggcttgtgtgtaggactAgagtcagtagccaggctgtc	8	10	15	8	0	1	1	1	0	0	1	2	2	1	2	1	3	1	4	1	3	3	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr6:110636640A>G	uc010kdu.1	-	3	462	c.462T>C	c.(460-462)TCT>TCC	p.S154S	C6orf186_uc003pub.2_Intron	NM_001123364	NP_001116836	Q5JXM2	CF186_HUMAN	chromosome 6 open reading frame 186 precursor	154						extracellular region					0						GTGTAGGACTAGAGTCAGTAG	0.433													13	85					0	0	0	0	G	110636640	G	G	110636640	2	3	196	1	0	0	0	0	0	0	0	1	2357	407	15	5		5	C6orf186	6	110636640	Silent	SNP	A	TCGA-CV-6937-01A-11D-2012-08	26801205	110636640	60478427	73	36145											
REV3L	5980	broad.mit.edu	37	chr6	111697876	111697876	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaatgtagcagcatctttgTgaaagatggagggtttaact	12	13	11	5	0	1	2	0	1	1	1	1	3	1	3	0	2	3	4	0	2	4	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr6:111697876T>C	uc003puy.3	-	13	2005	c.1682A>G	c.(1681-1683)CAC>CGC	p.H561R	REV3L_uc003pux.3_Missense_Mutation_p.H483R|REV3L_uc003puz.3_Missense_Mutation_p.H483R	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	561					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AGCATCTTTGTGAAAGATGGA	0.393								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					8	110					0	0	0	0	C	111697876	C	C	111697876	3	2	196	1	0	0	0	0	1	0	0	0	13305	1696	59	5	7790	5	REV3L	6	111697876	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	1061236	111697876	59417191	74	36146											
KATNA1	11104	broad.mit.edu	37	chr6	149944272	149944272	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctttattctgttctttcttTtcacgacaacgaacagcttt	8	18	4	11	2	4	0	1	0	3	0	4	2	4	0	1	0	3	2	1	0	3	8			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr6:149944272T>C	uc003qmr.1	-	3	513	c.468A>G	c.(466-468)GAA>GAG	p.E156E	KATNA1_uc003qms.2_Silent_p.E156E|KATNA1_uc003qmt.2_Silent_p.E156E|KATNA1_uc011eed.1_Silent_p.E156E	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1	156	Interaction with microtubule.				cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		GTTCTTTCTTTTCACGACAAC	0.343													8	55					0	0	0	0	C	149944272	C	C	149944272	2	2	196	1	0	0	0	0	0	0	0	1	8023	1838	64	5		5	KATNA1	6	149944272	Silent	SNP	T	TCGA-CV-6937-01A-11D-2012-08	38246396	149944272	21170795	75	36147											
MAP3K4	4216	broad.mit.edu	37	chr6	161530868	161530868	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggacttcaggaacatgtgAttaggctgtattcaaagcag	12	11	12	6	0	2	1	2	1	0	0	2	3	2	3	0	3	2	3	0	3	4	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr6:161530868A>G	uc003qtn.2	+	23	4460	c.4318A>G	c.(4318-4320)ATT>GTT	p.I1440V	MAP3K4_uc010kkc.1_Missense_Mutation_p.I1436V|MAP3K4_uc003qto.2_Missense_Mutation_p.I1390V|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.I893V|MAP3K4_uc003qtp.2_Missense_Mutation_p.I376V|MAP3K4_uc003qtq.2_Missense_Mutation_p.I129V	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1440	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GGAACATGTGATTAGGCTGTA	0.488													25	88					0	0	0	0	G	161530868	G	G	161530868	3	3	196	1	0	0	0	0	1	0	0	0	9305	333	12	5	4408	5	MAP3K4	6	161530868	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	11586596	161530868	9584199	76	36148											
C6orf70	55780	broad.mit.edu	37	chr6	170176742	170176742	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacgctgcggtctcgccagcGgcagaactacctgcgtatgt	7	8	13	13	5	1	1	0	0	1	1	2	2	1	1	2	2	5	3	2	2	3	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr6:170176742G>T	uc003qxg.1	+	16	1745	c.1712G>T	c.(1711-1713)CGG>CTG	p.R571L	C6orf70_uc011ehb.1_Missense_Mutation_p.R445L|C6orf70_uc003qxh.1_Intron|C6orf70_uc010kky.1_Intron|C6orf70_uc003qxi.1_Missense_Mutation_p.R219L	NM_018341	NP_060811	Q5T6L9	CF070_HUMAN	hypothetical protein LOC55780	571						integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		TCTCGCCAGCGGCAGAACTAC	0.597													11	47					2.80697e-09	1.69285e-08	1	0	T	170176742	T	T	170176742	3	4	196	1	0	0	0	0	1	0	0	0	2380	1116	39	3	1774	3	C6orf70	6	170176742	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	8645874	170176742	938325	77	36149											
NOD1	10392	broad.mit.edu	37	chr7	30486644	30486644	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacgtacctggctccgacatCggtgatctggttgttgtata	7	13	12	9	3	1	1	0	1	1	0	3	3	2	1	2	3	1	5	2	3	3	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:30486644C>T	uc003tav.2	-	8	2831	c.2308G>A	c.(2308-2310)GAT>AAT	p.D770N		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	770	LRR 4.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						GCTCCGACATCGGTGATCTGG	0.448													30	147					0	0	0	0	T	30486644	T	T	30486644	3	4	196	1	0	0	0	0	1	0	0	0	10570	884	31	1	581	1	NOD1	7	30486644	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08		30486644	128652019	78	36150											
ABCA13	154664	broad.mit.edu	37	chr7	48314127	48314127	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caccaaaaataataatttcaCctgaaataatgaaagctaca	21	9	3	8	0	1	2	1	2	0	0	1	2	1	2	2	0	2	1	2	0	8	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:48314127C>T	uc003toq.2	+	17	4889	c.4864C>T	c.(4864-4866)CCT>TCT	p.P1622S	ABCA13_uc010kyr.2_Missense_Mutation_p.P1125S	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1622					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AATAATTTCACCTGAAATAAT	0.378													26	218					0	0	0	0	T	48314127	T	T	48314127	3	4	196	1	0	0	0	0	1	0	0	0	31	507	18	4	4759	4	ABCA13	7	48314127	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	17827483	48314127	110824536	79	36151											
EGFR	1956	broad.mit.edu	37	chr7	55242489	55242489	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttaagagaagcaacatctccGaaagccaacaaggaaatcct	18	6	7	10	1	1	1	0	0	1	1	3	4	2	2	3	1	4	1	3	1	7	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:55242489G>A	uc003tqk.2	+	19	2505	c.2259G>A	c.(2257-2259)CCG>CCA	p.P753P	EGFR_uc010kzg.1_Silent_p.P708P|EGFR_uc011kco.1_Silent_p.P700P	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	753	Cytoplasmic (Potential).|Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L747_P753>S(166)|p.L747_P753del(21)|p.L747_P753>Q(19)|p.S752_I759del(15)|p.T751_I759>N(8)|p.E746_P753>VS(6)|p.P753S(4)|p.T751_I759>S(3)|p.A750_E758>P(3)|p.A750_K757del(2)|p.A750_E758del(2)|p.E746_P753del(2)|p.T751_I759>NKA(2)|p.E749_E758>QP(2)|p.T751_E758del(2)|p.L747_K754>ST(1)|p.T751_E758>A(1)|p.E746_P753>VQ(1)|p.T751_I759>REA(1)|p.L747_A755del(1)|p.P753_I759del(1)|p.P753F(1)|p.L747_A755>SKS(1)|p.L747_K754>N(1)|p.A750_K754del(1)|p.L747_K754del(1)|p.L747_K754>GC(1)|p.L747_N756>SKDD(1)|p.E749_P753>Q(1)|p.L747_P753>CG(1)|p.S752_V769del(1)|p.P753P(1)|p.R748_P753del(1)|p.E746_P753>LS(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAACATCTCCGAAAGCCAACA	0.493		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			7	70					0	0	0	0	A	55242489	A	A	55242489	2	1	196	1	0	0	0	0	0	0	0	1	4989	1045	37	1		1	EGFR	7	55242489	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	6928362	55242489	103896174	80	36152											
CALN1	83698	broad.mit.edu	37	chr7	71252883	71252883	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtctgttctgcttctgggaAtgcactggtggtgggagaag	6	13	16	6	0	3	1	0	0	3	1	3	3	3	2	0	4	2	3	0	4	2	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:71252883A>C	uc003twa.3	-	6	1064	c.537T>G	c.(535-537)CAT>CAG	p.H179Q	CALN1_uc003twb.3_Missense_Mutation_p.H221Q|CALN1_uc003twc.3_Missense_Mutation_p.H179Q	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	179	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				GCTTCTGGGAATGCACTGGTG	0.512													20	42					0	0	0	0	C	71252883	C	C	71252883	3	2	196	1	0	0	0	0	1	0	0	0	2603	98	4	5	126	5	CALN1	7	71252883	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	16010394	71252883	87885780	81	36153											
PPP1R9A	55607	broad.mit.edu	37	chr7	94750101	94750101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaaagctgggaatattcGtcaagacagtaacagaaggt	16	9	11	5	1	1	3	1	1	0	2	2	4	1	4	0	2	2	2	0	2	7	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:94750101G>A	uc003unp.2	+	4	1888	c.1606G>A	c.(1606-1608)GTC>ATC	p.V536I	PPP1R9A_uc010lfj.2_Missense_Mutation_p.V536I|PPP1R9A_uc011kif.1_Missense_Mutation_p.V536I|PPP1R9A_uc003unq.2_Missense_Mutation_p.V536I|PPP1R9A_uc011kig.1_Missense_Mutation_p.V536I	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	536	PDZ.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GGGAATATTCGTCAAGACAGT	0.393										HNSCC(28;0.073)			35	98					0	0	0	0	A	94750101	A	A	94750101	3	1	196	1	0	0	0	0	1	0	0	0	12438	1145	40	1	1616	1	PPP1R9A	7	94750101	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	23497218	94750101	64388562	82	36154											
SLC12A9	56996	broad.mit.edu	37	chr7	100463759	100463759	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accatcttgggcatggtgccCgcttggcatagcgcccggct	5	9	13	14	3	1	0	0	0	1	0	1	0	1	0	3	4	2	4	3	4	1	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:100463759C>A	uc003uwp.2	+	14	2419	c.2277C>A	c.(2275-2277)CCC>CCA	p.P759P	SLC12A9_uc011kki.1_Silent_p.P290P|SLC12A9_uc003uwr.2_Silent_p.P495P|SLC12A9_uc003uws.2_Silent_p.P290P|SLC12A9_uc003uwt.2_Silent_p.P495P|SLC12A9_uc003uwv.2_Silent_p.P290P|TRIP6_uc010lhk.1_5'Flank|TRIP6_uc003uww.2_5'Flank	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	759	Helical; (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					GCATGGTGCCCGCTTGGCATA	0.706													5	120					0.00116845	0.0064862	1	0	A	100463759	A	A	100463759	2	1	196	1	0	0	0	0	0	0	0	1	14455	639	23	3		3	SLC12A9	7	100463759	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	5713658	100463759	58674904	83	36155											
RELN	5649	broad.mit.edu	37	chr7	103183184	103183184	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaaatgattacctagcaTgtgataaatccaggtctcgt	14	12	7	8	1	1	2	0	2	1	0	3	2	2	2	2	1	2	1	2	1	7	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:103183184T>C	uc003vca.2	-	43	6825	c.6665A>G	c.(6664-6666)CAT>CGT	p.H2222R	RELN_uc010liz.2_Missense_Mutation_p.H2222R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2222					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTACCTAGCATGTGATAAATC	0.378													8	58					0	0	0	0	C	103183184	C	C	103183184	3	2	196	1	0	0	0	0	1	0	0	0	13285	1464	51	5	3809	5	RELN	7	103183184	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	2719425	103183184	55955479	84	36156											
RELN	5649	broad.mit.edu	37	chr7	103270583	103270583	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccatctgaactgaattcCaaactgctttgcatcacctg	11	11	5	14	0	2	2	1	2	1	0	3	2	3	2	4	0	4	2	4	0	3	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:103270583C>A	uc003vca.2	-	20	2666	c.2506G>T	c.(2506-2508)GGA>TGA	p.G836*	RELN_uc010liz.2_Nonsense_Mutation_p.G836*	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	836					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AACTGAATTCCAAACTGCTTT	0.343													7	72					0.000157383	0.000899202	1	0	A	103270583	A	A	103270583	4	1	196	1	0	0	0	0	0	1	0	0	13285	603	21	4	8060	4	RELN	7	103270583	Nonsense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	87399	103270583	55868080	85	36157											
DNAJB9	4189	broad.mit.edu	37	chr7	108213733	108213733	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcatggatctagcaagcactGcaggactgtcactcaacgaa	13	8	9	11	1	4	0	3	0	1	0	4	3	4	2	0	2	4	3	0	2	4	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:108213733G>A	uc003vfn.2	+	3	810	c.608G>A	c.(607-609)TGC>TAC	p.C203Y		NM_012328	NP_036460	Q9UBS3	DNJB9_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 9	203					ER-associated protein catabolic process|protein folding	endoplasmic reticulum|nucleolus	heat shock protein binding|misfolded protein binding|unfolded protein binding				0						AGCAAGCACTGCAGGACTGTC	0.373													18	60					0	0	0	0	A	108213733	A	A	108213733	3	1	196	1	0	0	0	0	1	0	0	0	4649	1319	46	4	614	4	DNAJB9	7	108213733	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	4943150	108213733	50924930	86	36158											
TMEM168	64418	broad.mit.edu	37	chr7	112423785	112423786	+	Frame_Shift_Ins	INS	-	A	A																															gctcccaaaatcgctgttgcINSaagaagactaaagaacacca																										TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:112423785_112423786insA	uc003vgn.2	-	2	1487_1488	c.1095_1096insT	c.(1093-1098)CTTGCAfs	p.L365fs	TMEM168_uc010lju.2_Frame_Shift_Ins_p.L365fs|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	365_366	Helical; (Potential).					integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						ATCGCTGTTGCAAGAAGACTAA	0.411													---	---	---								A	112423786	A	A	112423785	7	5	196	1	0	1	1	0	0	0	0	0	16149	710	25	0	1013	0	TMEM168	7	112423785	Frame_Shift_Ins	INS	-	TCGA-CV-6937-01A-11D-2012-08	4210052	112423785	46714878	87	36159											
TBXAS1	6916	broad.mit.edu	37	chr7	139575421	139575421	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatggagctcagaaagctgtAtggacctctgtgtgggtaag	11	10	14	6	0	2	1	1	0	1	1	2	3	2	3	1	3	2	4	1	3	4	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr7:139575421A>G	uc011kqv.1	+	3	388	c.224A>G	c.(223-225)TAT>TGT	p.Y75C	TBXAS1_uc003vvh.2_Missense_Mutation_p.Y75C|TBXAS1_uc010lne.2_Missense_Mutation_p.Y7C|TBXAS1_uc011kqu.1_Intron|TBXAS1_uc003vvi.2_Missense_Mutation_p.Y75C|TBXAS1_uc003vvj.2_Missense_Mutation_p.Y75C|TBXAS1_uc011kqw.1_Silent_p.V45V|TBXAS1_uc011kqx.1_Missense_Mutation_p.Y75C	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	74	Lumenal (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					AGAAAGCTGTATGGACCTCTG	0.338													3	52					0	0	0	0	G	139575421	G	G	139575421	3	3	196	1	0	0	0	0	1	0	0	0	15730	449	16	5	234	5	TBXAS1	7	139575421	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	27151636	139575421	19563242	88	36160											
PRKDC	5591	broad.mit.edu	37	chr8	48794645	48794645	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggtctaacatgccgttcAaaacggcactcacctgagac	11	9	8	13	2	4	1	2	1	2	1	4	2	4	1	2	2	3	2	2	2	3	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr8:48794645A>G	uc003xqi.2	-	38	4847	c.4790T>C	c.(4789-4791)TTG>TCG	p.L1597S	PRKDC_uc003xqj.2_Missense_Mutation_p.L1597S|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1597					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CATGCCGTTCAAAACGGCACT	0.393								NHEJ					56	110					0	0	0	0	G	48794645	G	G	48794645	3	3	196	1	0	0	0	0	1	0	0	0	12583	131	5	5	7796	5	PRKDC	8	48794645	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08		48794645	97569377	89	36161											
RNF19A	25897	broad.mit.edu	37	chr8	101273978	101273978	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttgcttctgctactgatgTtgtgtctaaatgcaaatatt	9	18	7	7	0	3	1	0	1	3	0	3	1	3	1	0	0	4	4	0	0	5	7			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr8:101273978T>C	uc003yjj.1	-	9	1791	c.1474A>G	c.(1474-1476)ACA>GCA	p.T492A	RNF19A_uc003yjk.1_Missense_Mutation_p.T492A	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	492					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			GCTACTGATGTTGTGTCTAAA	0.403													110	72					0	0	0	0	C	101273978	C	C	101273978	3	2	196	1	0	0	0	0	1	0	0	0	13535	1725	60	5	1054	5	RNF19A	8	101273978	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	52479333	101273978	45090044	90	36162											
PKHD1L1	93035	broad.mit.edu	37	chr8	110476615	110476615	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctggttgagaggaatattatAtatgatattaagggaggagc	14	12	13	2	0	0	2	0	2	0	1	0	6	0	5	0	4	1	1	0	4	7	7			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr8:110476615A>G	uc003yne.2	+	49	7658	c.7554A>G	c.(7552-7554)ATA>ATG	p.I2518M		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2518	PbH1 1.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGAATATTATATATGATATTA	0.363										HNSCC(38;0.096)			23	27					0	0	0	0	G	110476615	G	G	110476615	3	3	196	1	0	0	0	0	1	0	0	0	12027	439	16	5	7748	5	PKHD1L1	8	110476615	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	9202637	110476615	35887407	91	36163											
KCNQ3	3786	broad.mit.edu	37	chr8	133142023	133142023	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgactttgtcaatggtcAcctggtggaagctgtagggt	7	12	15	7	0	2	1	2	1	0	0	2	2	2	2	1	5	1	3	1	5	3	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr8:133142023A>C	uc003ytj.2	-	15	2330	c.2105T>G	c.(2104-2106)GTG>GGG	p.V702G	KCNQ3_uc010mdt.2_Missense_Mutation_p.V690G	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	702					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GTCAATGGTCACCTGGTGGAA	0.532													8	148					0	0	0	0	C	133142023	C	C	133142023	3	2	196	1	0	0	0	0	1	0	0	0	8123	159	6	5	517	5	KCNQ3	8	133142023	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	22665408	133142023	13221999	92	36164											
TG	7038	broad.mit.edu	37	chr8	134030138	134030138	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acctcatggaagcaagtggaCcagttccttggagttccata	11	10	10	10	0	1	0	1	0	0	0	3	3	3	3	4	3	1	3	4	3	3	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr8:134030138C>T	uc003ytw.2	+	38	6719	c.6678C>T	c.(6676-6678)GAC>GAT	p.D2226D	TG_uc010mdw.2_Silent_p.D985D|TG_uc011ljb.1_Silent_p.D595D|TG_uc011ljc.1_Silent_p.D359D	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2226					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCAAGTGGACCAGTTCCTTG	0.617													79	104					0	0	0	0	T	134030138	T	T	134030138	2	4	196	1	0	0	0	0	0	0	0	1	15879	506	18	4		4	TG	8	134030138	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	888115	134030138	12333884	93	36165											
GPR20	2843	broad.mit.edu	37	chr8	142367504	142367504	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaccggcggccagccacaCgaaggcgcacacggccctgg	8	1	15	17	5	0	0	0	0	0	0	0	1	0	0	4	6	1	2	4	6	1	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr8:142367504C>T	uc003ywf.2	-	2	609	c.520G>A	c.(520-522)GTG>ATG	p.V174M		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	174	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			GCCAGCCACACGAAGGCGCAC	0.711													8	8					0	0	0	0	T	142367504	T	T	142367504	3	4	196	1	0	0	0	0	1	0	0	0	6718	536	19	1	560	1	GPR20	8	142367504	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	8337366	142367504	3996518	94	36166											
AGTPBP1	23287	broad.mit.edu	37	chr9	88207485	88207485	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagttcttacctgtaaagttGaatacgtatatggatagtga	13	14	10	4	1	1	2	0	2	1	0	1	4	1	3	1	1	2	4	1	1	8	8			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr9:88207485G>A	uc011ltd.1	-	18	2591	c.2558C>T	c.(2557-2559)TCA>TTA	p.S853L	AGTPBP1_uc004aod.3_Missense_Mutation_p.S479L|AGTPBP1_uc011ltc.1_Intron|AGTPBP1_uc010mqc.2_Missense_Mutation_p.S813L|AGTPBP1_uc011lte.1_Missense_Mutation_p.S865L	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	853					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						CTGTAAAGTTGAATACGTATA	0.274													15	63					0	0	0	0	A	88207485	A	A	88207485	3	1	196	1	0	0	0	0	1	0	0	0	400	1294	45	2	1154	2	AGTPBP1	9	88207485	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08		88207485	53005946	95	36167											
ALG2	85365	broad.mit.edu	37	chr9	101980621	101980621	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaccattttcttcaattcCtgataatgttccacattctc	9	17	4	11	0	3	1	1	1	2	0	6	2	5	2	3	1	0	1	3	1	2	7			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr9:101980621C>T	uc004azf.2	-	2	916	c.846G>A	c.(844-846)CAG>CAA	p.Q282Q	ALG2_uc004azg.2_Silent_p.Q189Q	NM_033087	NP_149078	Q9H553	ALG2_HUMAN	alpha-1,3-mannosyltransferase ALG2	282					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.0559)				TCTTCAATTCCTGATAATGTT	0.483													32	73					0	0	0	0	T	101980621	T	T	101980621	2	4	196	1	0	0	0	0	0	0	0	1	519	680	24	4		4	ALG2	9	101980621	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	13773136	101980621	39232810	96	36168											
DENND1A	57706	broad.mit.edu	37	chr9	126414316	126414316	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagtttgctgcaaatgatGagtatccggcgttcgtacag	9	12	12	8	3	0	3	0	3	0	0	2	3	1	3	1	1	3	6	1	1	3	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr9:126414316G>A	uc004bnz.1	-	9	827	c.594C>T	c.(592-594)CTC>CTT	p.L198L	DENND1A_uc011lzl.1_Silent_p.L15L|DENND1A_uc004bny.1_Silent_p.L15L|DENND1A_uc011lzm.1_Silent_p.L166L|DENND1A_uc004boa.1_Silent_p.L198L|DENND1A_uc004bob.1_Silent_p.L168L|DENND1A_uc004boc.2_Silent_p.L166L	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	198	DENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						TGCAAATGATGAGTATCCGGC	0.388													9	35					0	0	0	0	A	126414316	A	A	126414316	2	1	196	1	0	0	0	0	0	0	0	1	4448	1277	45	2		2	DENND1A	9	126414316	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	24433695	126414316	14799115	97	36169											
FUBP3	8939	broad.mit.edu	37	chr9	133506175	133506175	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatagatgagaaagttggCgtacgtacagggtccttccc	10	10	11	10	2	1	2	1	1	0	2	3	3	3	2	2	2	2	3	2	2	4	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr9:133506175C>T	uc004bzr.1	+	13	1386	c.1278C>T	c.(1276-1278)GGC>GGT	p.G426G	FUBP3_uc004bzs.1_Silent_p.G339G	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	426					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		AGAAAGTTGGCGTACGTACAG	0.567													6	19					0	0	0	0	T	133506175	T	T	133506175	2	4	196	1	0	0	0	0	0	0	0	1	6127	782	27	1		1	FUBP3	9	133506175	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	7091859	133506175	7707256	98	36170											
ADARB2	105	broad.mit.edu	37	chr10	1405267	1405267	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cctgccgggcgcgtggccggGcatctggatgtcgaacagct	5	7	16	13	5	1	0	0	0	1	0	2	2	1	1	3	4	3	2	3	4	1	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr10:1405267G>A	uc009xhq.2	-	3	1407	c.1033C>T	c.(1033-1035)CCC>TCC	p.P345S		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	345					mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GCGTGGCCGGGCATCTGGATG	0.761													5	12					0	0	0	0	A	1405267	A	A	1405267	3	1	196	1	0	0	0	0	1	0	0	0	283	1203	42	4	1218	4	ADARB2	10	1405267	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08		1405267	134129480	99	36171											
TTC18	118491	broad.mit.edu	37	chr10	75104930	75104930	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaacgtgaccttcagtaGattgccccctgagatctggg	8	10	10	13	1	2	3	1	2	1	2	3	4	3	3	4	1	2	1	4	1	2	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr10:75104930G>T	uc009xrc.2	-	6	623	c.502C>A	c.(502-504)CTA>ATA	p.L168I	TTC18_uc001jty.2_Missense_Mutation_p.L168I|TTC18_uc009xrd.1_5'UTR	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	168							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					ACCTTCAGTAGATTGCCCCCT	0.468													32	123					5.91797e-21	3.68271e-20	1	0	T	75104930	T	T	75104930	3	4	196	1	0	0	0	0	1	0	0	0	16753	933	33	2	2955	2	TTC18	10	75104930	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	73699663	75104930	60429817	100	36172											
MYOZ1	58529	broad.mit.edu	37	chr10	75397509	75397509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttccagactcaccattgagCtgtcagagaaaacatcaggg	13	8	10	10	0	3	3	3	1	0	2	4	4	4	3	2	1	2	2	2	1	2	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr10:75397509C>T	uc001jur.2	-	3	610	c.245G>A	c.(244-246)AGC>AAC	p.S82N		NM_021245	NP_067068	Q9NP98	MYOZ1_HUMAN	myozenin 1	82					myofibril assembly	nucleus|pseudopodium	FATZ binding			ovary(2)	2	Prostate(51;0.0112)					CACCATTGAGCTGTCAGAGAA	0.483													25	108					0	0	0	0	T	75397509	T	T	75397509	3	4	196	1	0	0	0	0	1	0	0	0	10148	797	28	4	670	4	MYOZ1	10	75397509	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	292579	75397509	60137238	101	36173											
CNNM1	26507	broad.mit.edu	37	chr10	101120712	101120712	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacagcttctgctagccaCacaccgcttcatggccacag	10	7	7	17	1	2	0	1	0	1	0	2	0	2	0	4	1	3	3	4	1	1	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr10:101120712C>T	uc001kpp.3	+	3	2127	c.1838C>T	c.(1837-1839)ACA>ATA	p.T613I	CNNM1_uc009xwe.2_Missense_Mutation_p.T613I|CNNM1_uc010qpi.1_Missense_Mutation_p.T613I|CNNM1_uc009xwf.2_Missense_Mutation_p.T613I|CNNM1_uc009xwg.2_Missense_Mutation_p.T13I	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	613					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		CTGCTAGCCACACACCGCTTC	0.383													16	57					0	0	0	0	T	101120712	T	T	101120712	3	4	196	1	0	0	0	0	1	0	0	0	3627	478	17	4	1848	4	CNNM1	10	101120712	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	25723203	101120712	34414035	102	36174											
GBF1	8729	broad.mit.edu	37	chr10	104122290	104122290	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctactatctcttgatgcccTattgacagtgattgacagca	10	13	7	11	0	1	4	0	4	1	0	2	4	1	4	2	0	3	1	2	0	3	6			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr10:104122290T>C	uc001kux.1	+	15	1982	c.1742T>C	c.(1741-1743)CTA>CCA	p.L581P	GBF1_uc001kuy.1_Missense_Mutation_p.L581P|GBF1_uc001kuz.1_Missense_Mutation_p.L582P	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	581					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CTTGATGCCCTATTGACAGTG	0.488													3	148					0	0	0	0	C	104122290	C	C	104122290	3	2	196	1	0	0	0	0	1	0	0	0	6306	1522	53	5	1796	5	GBF1	10	104122290	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	3001578	104122290	31412457	103	36175											
OR52E2	119678	broad.mit.edu	37	chr11	5080740	5080740	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtgaagttccctatgagtgCgatcatgtacacagcacaga	13	9	10	9	1	1	3	1	2	0	1	2	4	2	3	1	0	3	3	1	0	3	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr11:5080740C>T	uc010qyw.1	-	1	118	c.118G>A	c.(118-120)GCA>ACA	p.A40T		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCTATGAGTGCGATCATGTAC	0.512													13	52					0	0	0	0	T	5080740	T	T	5080740	3	4	196	1	0	0	0	0	1	0	0	0	11169	768	27	1	862	1	OR52E2	11	5080740	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08		5080740	129925776	104	36176											
RBMXL2	27288	broad.mit.edu	37	chr11	7111302	7111302	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccggggctactcacccgaTgcctacagcggcggccgcga	7	5	13	16	6	1	0	1	0	0	0	1	2	1	0	4	4	5	1	4	4	3	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr11:7111302T>C	uc001mfc.2	+	1	1138	c.951T>C	c.(949-951)GAT>GAC	p.D317D		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	317	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACTCACCCGATGCCTACAGCG	0.687													7	27					0	0	0	0	C	7111302	C	C	7111302	2	2	196	1	0	0	0	0	0	0	0	1	13219	1461	51	5		5	RBMXL2	11	7111302	Silent	SNP	T	TCGA-CV-6937-01A-11D-2012-08	2030562	7111302	127895214	105	36177											
MRGPRX3	117195	broad.mit.edu	37	chr11	18159705	18159705	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggagctgtcgggaagcaGattggagcagtgaggaagaa	12	6	17	6	1	0	3	0	1	0	2	1	7	0	7	1	4	3	3	1	4	3	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr11:18159705G>C	uc001mnu.2	+	3	1317	c.956G>C	c.(955-957)AGA>ACA	p.R319T		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	319	Cytoplasmic (Potential).			R -> K (in Ref. 2; AAL86878).		integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						TCGGGAAGCAGATTGGAGCAG	0.542													4	56					0	0	0	0	C	18159705	C	C	18159705	3	2	196	1	0	0	0	0	1	0	0	0	9821	942	33	2	958	2	MRGPRX3	11	18159705	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	11048403	18159705	116846811	106	36178											
SLC1A2	6506	broad.mit.edu	37	chr11	35308409	35308409	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taccatccatgttaatggttGctccaacaggaaggacgaat	13	10	9	9	1	0	0	0	0	0	0	2	3	2	2	3	3	3	3	3	3	5	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr11:35308409G>A	uc001mwd.2	-	8	1773	c.1181C>T	c.(1180-1182)GCA>GTA	p.A394V	SLC1A2_uc001mwe.2_Missense_Mutation_p.A385V|SLC1A2_uc010rev.1_Missense_Mutation_p.A394V	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	394					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	GTTAATGGTTGCTCCAACAGG	0.468													24	190					0	0	0	0	A	35308409	A	A	35308409	3	1	196	1	0	0	0	0	1	0	0	0	14497	1319	46	4	559	4	SLC1A2	11	35308409	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	17148704	35308409	99698107	107	36179											
OR8J1	219477	broad.mit.edu	37	chr11	56128260	56128260	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taatcaatcatttttactgtGataatgttcctctgttagca	11	18	5	7	0	3	1	2	1	1	0	4	1	4	1	1	0	2	3	1	0	5	7			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr11:56128260G>C	uc010rjh.1	+	1	538	c.538G>C	c.(538-540)GAT>CAT	p.D180H		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TTTTTACTGTGATAATGTTCC	0.343													21	62					0	0	0	0	C	56128260	C	C	56128260	3	2	196	1	0	0	0	0	1	0	0	0	11295	1290	45	2	540	2	OR8J1	11	56128260	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	20819851	56128260	78878256	108	36180											
OR5AR1	219493	broad.mit.edu	37	chr11	56431506	56431506	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgctgagtgctatgtcctGgcagccatggcctatggtcg	6	11	14	10	1	0	1	0	1	0	0	2	2	1	1	3	3	3	3	3	3	2	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr11:56431506G>C	uc010rjm.1	+	1	345	c.345G>C	c.(343-345)CTG>CTC	p.L115L		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTATGTCCTGGCAGCCATGG	0.498													31	213					0	0	0	0	C	56431506	C	C	56431506	2	2	196	1	0	0	0	0	0	0	0	1	11199	1335	47	4		4	OR5AR1	11	56431506	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	303246	56431506	78575010	109	36181											
KCNA6	3742	broad.mit.edu	37	chr12	4919817	4919817	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccagttccgtgtagatggtCgaggtggaaacaatggtggt	9	10	15	7	2	0	1	0	0	0	1	2	3	1	2	2	5	1	2	2	5	3	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr12:4919817C>T	uc001qng.2	+	1	1476	c.610C>T	c.(610-612)CGA>TGA	p.R204*		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	204						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						TGTAGATGGTCGAGGTGGAAA	0.542										HNSCC(72;0.22)			11	60					0	0	0	0	T	4919817	T	T	4919817	4	4	196	1	0	0	0	0	0	1	0	0	8046	876	31	1	612	1	KCNA6	12	4919817	Nonsense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08		4919817	128932078	110	36182											
KCNA1	3736	broad.mit.edu	37	chr12	5020755	5020755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaaccctaagaaacgcatgCgctacttcgaccccctgagg	11	6	9	15	3	0	2	0	1	0	1	1	3	0	2	3	1	4	3	3	1	4	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr12:5020755C>T	uc001qnh.2	+	2	1316	c.211C>T	c.(211-213)CGC>TGC	p.R71C		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	71					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAAACGCATGCGCTACTTCGA	0.632													27	105					0	0	0	0	T	5020755	T	T	5020755	3	4	196	1	0	0	0	0	1	0	0	0	8040	768	27	1	213	1	KCNA1	12	5020755	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	100938	5020755	128831140	111	36183											
USP5	8078	broad.mit.edu	37	chr12	6970649	6970649	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaagcggcaagccgaagAggagaagatggcactgccag	15	2	16	8	2	0	4	0	0	0	4	0	7	0	4	2	3	3	2	2	3	5	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr12:6970649A>G	uc001qri.3	+	13	1600	c.1541A>G	c.(1540-1542)GAG>GGG	p.E514G	USP5_uc001qrh.3_Missense_Mutation_p.E514G	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	514					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						CAAGCCGAAGAGGAGAAGATG	0.597													20	94					0	0	0	0	G	6970649	G	G	6970649	3	3	196	1	0	0	0	0	1	0	0	0	17149	304	11	5	1591	5	USP5	12	6970649	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	1949894	6970649	126881246	112	36184											
OR8S1	341568	broad.mit.edu	37	chr12	48921776	48921776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaagagaccagccttcaccGaaggccgcagggagcccgga	11	2	15	13	3	1	1	1	0	0	1	1	6	1	4	5	4	2	1	5	4	2	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr12:48921776G>A	uc010slu.1	+	2	970	c.970G>A	c.(970-972)GAA>AAA	p.E324K		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	324	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGCCTTCACCGAAGGCCGCAG	0.647													18	27					0	0	0	0	A	48921776	A	A	48921776	3	1	196	1	0	0	0	0	1	0	0	0	11300	1059	37	1	976	1	OR8S1	12	48921776	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	41951127	48921776	84930119	113	36185											
USP15	9958	broad.mit.edu	37	chr12	62749159	62749159	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcatataccgcttataagaActatgattattcggaacctg	14	13	6	8	2	1	2	1	1	0	1	2	3	1	3	2	1	3	1	2	1	8	7			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr12:62749159A>G	uc001src.1	+	8	827	c.818A>G	c.(817-819)AAC>AGC	p.N273S	USP15_uc001srb.1_Missense_Mutation_p.N244S	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	273					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GCTTATAAGAACTATGATTAT	0.348													7	31					0	0	0	0	G	62749159	G	G	62749159	3	3	196	1	0	0	0	0	1	0	0	0	17114	43	2	5	757	5	USP15	12	62749159	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	13827383	62749159	71102736	114	36186											
EPYC	1833	broad.mit.edu	37	chr12	91366624	91366624	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgcaaagtcatttttgttGatctttttaattctgttaaa	10	21	5	5	0	3	1	1	1	2	0	3	1	3	1	0	0	1	3	0	0	4	9			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr12:91366624G>C	uc001tbk.2	-	4	567	c.474C>G	c.(472-474)ATC>ATG	p.I158M		NM_004950	NP_004941	Q99645	EPYC_HUMAN	dermatan sulfate proteoglycan 3 precursor	158	LRR 1.				female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			skin(1)	1						CATTTTTGTTGATCTTTTTAA	0.388													6	110					0	0	0	0	C	91366624	C	C	91366624	3	2	196	1	0	0	0	0	1	0	0	0	5225	1280	45	2	510	2	EPYC	12	91366624	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	28617465	91366624	42485271	115	36187											
TRPV4	59341	broad.mit.edu	37	chr12	110246181	110246181	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggtcagcagtggagcccCgggacacgatgtcaaagagg	11	4	15	11	2	2	1	2	0	0	1	2	4	2	3	3	4	2	1	3	4	1	0	rs139300843		TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr12:110246181C>T	uc001tpj.1	-	2	574	c.479G>A	c.(478-480)CGG>CAG	p.R160Q	TRPV4_uc001tpg.1_Missense_Mutation_p.R126Q|TRPV4_uc001tph.1_Missense_Mutation_p.R160Q|TRPV4_uc001tpi.1_Missense_Mutation_p.R160Q|TRPV4_uc001tpk.1_Missense_Mutation_p.R160Q|TRPV4_uc001tpl.1_Missense_Mutation_p.R160Q	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	160	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AGTGGAGCCCCGGGACACGAT	0.612													13	36					0	0	0	0	T	110246181	T	T	110246181	3	4	196	1	0	0	0	0	1	0	0	0	16665	652	23	1	2192	1	TRPV4	12	110246181	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	18879557	110246181	23605714	116	36188											
RPH3A	22895	broad.mit.edu	37	chr12	113307581	113307581	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtgacagtgaagataggAggggcccgggtcagaagaca	13	4	17	7	1	1	5	1	2	0	3	1	6	1	6	1	5	0	0	1	5	3	1			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr12:113307581A>G	uc010syl.1	+	9	990	c.628A>G	c.(628-630)AGG>GGG	p.R210G	RPH3A_uc001ttz.2_Missense_Mutation_p.R210G|RPH3A_uc001tty.2_Missense_Mutation_p.R206G|RPH3A_uc009zwe.1_Missense_Mutation_p.R206G|RPH3A_uc010sym.1_Missense_Mutation_p.R161G|RPH3A_uc001tua.2_5'UTR	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	210	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		TGAAGATAGGAGGGGCCCGGG	0.463													3	139					0	0	0	0	G	113307581	G	G	113307581	3	3	196	1	0	0	0	0	1	0	0	0	13616	295	11	5	654	5	RPH3A	12	113307581	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	3061400	113307581	20544314	117	36189											
PCNX	22990	broad.mit.edu	37	chr14	71444809	71444809	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactatgtttgctttcgaggTgtttctggtaccaagccaca	8	14	10	9	1	1	0	0	0	1	0	2	2	1	0	2	2	3	4	2	2	3	5			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr14:71444809T>A	uc001xmo.2	+	6	2201	c.1755T>A	c.(1753-1755)GGT>GGA	p.G585G	PCNX_uc001xmn.3_Silent_p.G585G|PCNX_uc010are.1_Silent_p.G585G	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	585						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GCTTTCGAGGTGTTTCTGGTA	0.483													15	99					0	0	0	0	A	71444809	A	A	71444809	2	1	196	1	0	0	0	0	0	0	0	1	11645	1683	59	5		5	PCNX	14	71444809	Silent	SNP	T	TCGA-CV-6937-01A-11D-2012-08		71444809	35904731	118	36190											
DCAF4	26094	broad.mit.edu	37	chr14	73422322	73422322	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagggatggaaggccacccGcctgtttcatgattcagcag	10	8	12	11	1	2	1	2	1	0	0	2	3	2	3	3	3	1	2	3	3	2	2	rs141315052	byFrequency	TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr14:73422322G>A	uc001xng.2	+	12	1317	c.1097G>A	c.(1096-1098)CGC>CAC	p.R366H	DCAF4_uc001xnj.2_Missense_Mutation_p.R360H|DCAF4_uc010ttr.1_Missense_Mutation_p.R345H|DCAF4_uc001xnh.2_Missense_Mutation_p.R266H|DCAF4_uc010tts.1_Missense_Mutation_p.R306H|DCAF4_uc010ttt.1_Missense_Mutation_p.R152H|DCAF4_uc001xni.2_Missense_Mutation_p.R196H|DCAF4_uc001xnk.2_Missense_Mutation_p.R366H	NM_015604	NP_056419	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4 isoform 1	366						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)|skin(1)	3						AAGGCCACCCGCCTGTTTCAT	0.517													42	238					0	0	0	0	A	73422322	A	A	73422322	3	1	196	1	0	0	0	0	1	0	0	0	4287	1087	38	1	1142	1	DCAF4	14	73422322	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	1977513	73422322	33927218	119	36191											
TMEM63C	57156	broad.mit.edu	37	chr14	77722968	77722968	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatgaacaaccagccggaaGagggagaagaagagagtggt	16	3	15	7	1	0	5	0	1	0	4	0	8	0	6	3	3	3	0	3	3	5	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr14:77722968G>C	uc001xtf.2	+	24	2532	c.2320G>C	c.(2320-2322)GAG>CAG	p.E774Q	TMEM63C_uc010asq.1_Missense_Mutation_p.E774Q	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	774						integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		CCAGCCGGAAGAGGGAGAAGA	0.607													60	131					0	0	0	0	C	77722968	C	C	77722968	3	2	196	1	0	0	0	0	1	0	0	0	16258	943	33	2	2406	2	TMEM63C	14	77722968	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	4300646	77722968	29626572	120	36192											
BTBD7	55727	broad.mit.edu	37	chr14	93723663	93723663	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtctttttacacctctttTgttcacactatgggcagtgc	6	16	7	12	1	3	0	1	0	2	0	3	0	3	0	2	1	2	2	2	1	2	7			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr14:93723663T>G	uc001ybo.2	-	6	1812	c.1486A>C	c.(1486-1488)AAA>CAA	p.K496Q	BTBD7_uc010aur.2_Missense_Mutation_p.K21Q|BTBD7_uc010two.1_Missense_Mutation_p.K316Q|BTBD7_uc001ybp.2_Missense_Mutation_p.K145Q|BTBD7_uc001ybq.3_Missense_Mutation_p.K411Q	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	496										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACACCTCTTTTGTTCACACTA	0.408													8	83					0	0	0	0	G	93723663	G	G	93723663	3	3	196	1	0	0	0	0	1	0	0	0	1551	1821	63	5	1936	5	BTBD7	14	93723663	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	16000695	93723663	13625877	121	36193											
DICER1	23405	broad.mit.edu	37	chr14	95571506	95571506	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggcagtgaaggcgataaagTatgctggggagacaaacagc	15	5	15	6	1	0	2	0	1	0	1	0	4	0	2	0	4	3	3	0	4	5	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr14:95571506T>A	uc001ydw.2	-	21	3353	c.3171A>T	c.(3169-3171)ATA>ATT	p.I1057I	DICER1_uc010avh.1_5'UTR|DICER1_uc001ydv.2_Silent_p.I1047I|DICER1_uc001ydx.2_Silent_p.I1057I|DICER1_uc001ydy.1_5'Flank	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1057					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GGCGATAAAGTATGCTGGGGA	0.488			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				28	169					0	0	0	0	A	95571506	A	A	95571506	2	1	196	1	0	0	0	0	0	0	0	1	4543	1628	57	5		5	DICER1	14	95571506	Silent	SNP	T	TCGA-CV-6937-01A-11D-2012-08	1847843	95571506	11778034	122	36194											
MYEF2	50804	broad.mit.edu	37	chr15	48446066	48446066	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgtccacccggaccaagtCccatcccaatgcctccaaga	10	6	7	18	1	0	1	0	0	0	1	4	2	4	2	7	1	1	1	7	1	3	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr15:48446066C>A	uc001zwi.3	-	10	1134	c.1010G>T	c.(1009-1011)GGA>GTA	p.G337V	MYEF2_uc001zwh.3_5'Flank|MYEF2_uc001zwj.3_Missense_Mutation_p.G337V|MYEF2_uc001zwl.2_Missense_Mutation_p.G177V	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	337	Gly-rich.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		CGGACCAAGTCCCATCCCAAT	0.388													8	23					0.000274275	0.00154894	1	0	A	48446066	A	A	48446066	3	1	196	1	0	0	0	0	1	0	0	0	10077	855	30	2	824	2	MYEF2	15	48446066	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08		48446066	54085326	123	36195											
LAT	27040	broad.mit.edu	37	chr16	28997738	28997738	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgggggctcccaccggaCgccatcttcccggcgggatt	4	8	13	16	4	1	0	0	0	1	0	3	2	3	2	5	5	0	1	5	5	0	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr16:28997738C>T	uc002dsd.2	+	5	633	c.281C>T	c.(280-282)ACG>ATG	p.T94M	uc010vct.1_Intron|LAT_uc010vdj.1_Missense_Mutation_p.T130M|LAT_uc002dsb.2_Missense_Mutation_p.T94M|LAT_uc002dsc.2_Missense_Mutation_p.T93M|LAT_uc010vdk.1_Missense_Mutation_p.T94M|LAT_uc010vdl.1_Missense_Mutation_p.T93M	NM_014387	NP_055202	O43561	LAT_HUMAN	linker for activation of T cells isoform a	94	Cytoplasmic (Potential).				calcium-mediated signaling|integrin-mediated signaling pathway|mast cell degranulation|platelet activation|Ras protein signal transduction|regulation of T cell activation|T cell receptor signaling pathway	immunological synapse|integral to membrane|intracellular|membrane raft	SH3/SH2 adaptor activity				0		Hepatocellular(780;0.244)				TCCCACCGGACGCCATCTTCC	0.627													22	89					0	0	0	0	T	28997738	T	T	28997738	3	4	196	1	0	0	0	0	1	0	0	0	8684	536	19	1	411	1	LAT	16	28997738	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08		28997738	61357015	124	36196											
CDH1	999	broad.mit.edu	37	chr16	68853324	68853324	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctaatcatagctacagaCaatggtaagggggcctcatc	12	8	10	11	0	2	1	2	0	0	1	3	1	2	1	2	3	2	2	2	3	5	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr16:68853324C>A	uc002ewg.1	+	11	1831	c.1707C>A	c.(1705-1707)GAC>GAA	p.D569E	CDH1_uc010vlj.1_Intron|CDH1_uc010cfg.1_Missense_Mutation_p.D508E	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	569	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TAGCTACAGACAATGGTAAGG	0.522			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				11	32					5.50884e-06	3.24225e-05	1	0	A	68853324	A	A	68853324	3	1	196	1	0	0	0	0	1	0	0	0	3110	477	17	4	1749	4	CDH1	16	68853324	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	39855586	68853324	21501429	125	36197											
ADAD2	161931	broad.mit.edu	37	chr16	84229512	84229512	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgaagcctgtgtgctacGtggcgccctcgctctgtgac	5	10	13	13	3	1	2	0	2	1	0	2	2	1	2	2	1	4	3	2	1	2	1	rs142081193	byFrequency	TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr16:84229512G>C	uc002fhr.2	+	7	1258	c.1144G>C	c.(1144-1146)GTG>CTG	p.V382L	ADAD2_uc002fhq.2_Missense_Mutation_p.V464L|uc002fhs.1_Intron	NM_001145400	NP_001138872	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2 isoform	382	A to I editase.				RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding				0						TGTGTGCTACGTGGCGCCCTC	0.716													5	32					0	0	0	0	C	84229512	C	C	84229512	3	2	196	1	0	0	0	0	1	0	0	0	232	1145	40	3	1420	3	ADAD2	16	84229512	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	15376188	84229512	6125241	126	36198											
GAS8	2622	broad.mit.edu	37	chr16	90103725	90103725	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagaacaagcgcctggcagAccctctccagaaggctcggg	10	4	13	14	2	1	3	0	0	1	3	3	3	1	3	3	3	2	3	3	3	3	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr16:90103725A>C	uc002fqi.1	+	7	964	c.842A>C	c.(841-843)GAC>GCC	p.D281A	GAS8_uc010vps.1_Missense_Mutation_p.D256A|GAS8_uc002fqh.2_Missense_Mutation_p.D198A|GAS8_uc010vpt.1_3'UTR|GAS8_uc010vpu.1_3'UTR|GAS8_uc010vpv.1_Missense_Mutation_p.D252A|GAS8_uc010cjc.1_Missense_Mutation_p.D198A|GAS8_uc010vpw.1_Missense_Mutation_p.D198A|GAS8_uc002fqj.1_Missense_Mutation_p.D89A	NM_001481	NP_001472	O95995	GAS8_HUMAN	growth arrest-specific 8	281	Potential.				negative regulation of cell proliferation|sperm motility	cilium|Golgi apparatus|microtubule|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.029)		CGCCTGGCAGACCCTCTCCAG	0.582													14	31					0	0	0	0	C	90103725	C	C	90103725	3	2	196	1	0	0	0	0	1	0	0	0	6286	275	10	5	868	5	GAS8	16	90103725	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	5874213	90103725	251028	127	36199											
TP53	7157	broad.mit.edu	37	chr17	7578232	7578232	+	Frame_Shift_Del	DEL	A	-	-																															gaaaagtgtttctgtcatccAaatactccacacgcaaattt																										TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr17:7578232delA	uc002gim.2	-	6	811	c.617delT	c.(616-618)TTGfs	p.L206fs	TP53_uc002gig.1_Frame_Shift_Del_p.L206fs|TP53_uc002gih.2_Frame_Shift_Del_p.L206fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.L74fs|TP53_uc010cng.1_Frame_Shift_Del_p.L74fs|TP53_uc002gii.1_Frame_Shift_Del_p.L74fs|TP53_uc010cnh.1_Frame_Shift_Del_p.L206fs|TP53_uc010cni.1_Frame_Shift_Del_p.L206fs|TP53_uc002gij.2_Frame_Shift_Del_p.L206fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.L113fs|TP53_uc002gio.2_Frame_Shift_Del_p.L74fs|TP53_uc010vug.1_Frame_Shift_Del_p.L167fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	206	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> F (in a sporadic cancer; somatic mutation).|L -> M (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L206*(5)|p.L206fs*41(4)|p.K164_P219del(1)|p.L206F(1)|p.?fs(1)|p.L206L(1)|p.E204fs*39(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTCATCCAAATACTCCAC	0.547		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578232	-	-	7578232	7	5	196	1	0	1	0	1	0	0	0	0	16448	131	5	0	677	0	TP53	17	7578232	Frame_Shift_Del	DEL	A	TCGA-CV-6937-01A-11D-2012-08		7578232	73616978	128	36200											
PIK3R5	23533	broad.mit.edu	37	chr17	8793324	8793324	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagccagctttttctcccacCgcctgcagcttggtcctgag	6	11	9	15	1	1	1	0	1	1	0	3	1	2	1	5	1	4	3	5	1	1	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr17:8793324C>T	uc002glt.2	-	8	844	c.777G>A	c.(775-777)GCG>GCA	p.A259A	PIK3R5_uc010vuz.1_Silent_p.A259A|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Intron|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	259				AKTLAELEDIFTETAEAQELASGIGDAAEARRWLRTKLQAV GEKAGFPGVLDTAKPGKLHTIPIPVARCYTYSWSQDS -> TLQNQGSSIPSPSLSPGATPTAGARTALTSCRKSCSRNRSC SSQGSWEMMKRRKRRRRRWRRTWKLMGTVPREIPCSP (in Ref. 6; AAW63122).	platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						TTTCTCCCACCGCCTGCAGCT	0.577													20	46					0	0	0	0	T	8793324	T	T	8793324	2	4	196	1	0	0	0	0	0	0	0	1	11977	639	23	1		1	PIK3R5	17	8793324	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	1215092	8793324	72401886	129	36201											
OSBPL1A	114876	broad.mit.edu	37	chr18	21745096	21745097	+	Frame_Shift_Ins	INS	-	T	T																															ctttgtttttcctcaagtcgINSttttttttcttcactagctt																										TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr18:21745096_21745097insT	uc002kve.2	-	27	2856_2857	c.2682_2683insA	c.(2680-2685)AAACGAfs	p.K894fs	OSBPL1A_uc002kvd.2_Frame_Shift_Ins_p.K381fs|OSBPL1A_uc010xbc.1_Frame_Shift_Ins_p.K512fs	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	894_895	Potential.				cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					TCCTCAAGTCGTTTTTTTTCTT	0.46													---	---	---								T	21745097	T	T	21745096	7	5	196	1	0	1	1	0	0	0	0	0	11331	1153	40	0	177	0	OSBPL1A	18	21745096	Frame_Shift_Ins	INS	-	TCGA-CV-6937-01A-11D-2012-08		21745096	56332152	130	36202											
MYO9B	4650	broad.mit.edu	37	chr19	17322582	17322582	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccgggcggggggcctcggaAggtcagtattaaggtagcgt	7	7	19	8	4	1	0	1	0	0	0	2	1	1	1	2	7	1	2	2	7	4	3			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr19:17322582A>T	uc010eak.2	+	39	6209	c.6057A>T	c.(6055-6057)GAA>GAT	p.E2019D	MYO9B_uc002nfi.2_Missense_Mutation_p.E2019D|MYO9B_uc002nfm.1_Missense_Mutation_p.E179D	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	2019	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GGGCCTCGGAAGGTCAGTATT	0.677													11	50					0	0	0	0	T	17322582	T	T	17322582	3	4	196	1	0	0	0	0	1	0	0	0	10138	86	3	5	6207	5	MYO9B	19	17322582	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08		17322582	41806401	131	36203											
ZNF675	171392	broad.mit.edu	37	chr19	23844924	23844924	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attctcacttacctgggggtTcattcaccatctcatgtctc	7	15	6	13	0	5	0	4	0	3	0	8	0	5	0	2	2	1	1	2	2	1	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr19:23844924T>G	uc002nri.2	-	3	400	c.218A>C	c.(217-219)GAA>GCA	p.E73A		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	73	KRAB.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ACCTGGGGGTTCATTCACCAT	0.418													28	98					0	0	0	0	G	23844924	G	G	23844924	3	3	196	1	0	0	0	0	1	0	0	0	18149	1783	62	5	1496	5	ZNF675	19	23844924	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	6522342	23844924	35284059	132	36204											
TMEM147	10430	broad.mit.edu	37	chr19	36037696	36037696	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgggctgggccactgctgaGcttattatgtcccggtgcgt	4	12	14	11	2	0	1	0	1	0	0	1	1	1	1	2	3	3	3	2	3	2	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr19:36037696G>A	uc002oaj.1	+	4	427	c.330G>A	c.(328-330)GAG>GAA	p.E110E	uc010eec.1_5'Flank|uc002oag.2_5'Flank|TMEM147_uc002oai.1_Silent_p.E61E|TMEM147_uc002oak.1_Missense_Mutation_p.S20N	NM_032635	NP_116024	Q9BVK8	TM147_HUMAN	transmembrane protein 147	110	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCACTGCTGAGCTTATTATGT	0.602													7	73					0	0	0	0	A	36037696	A	A	36037696	2	1	196	1	0	0	0	0	0	0	0	1	16127	962	34	4		4	TMEM147	19	36037696	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	12192772	36037696	23091287	133	36205											
APLP1	333	broad.mit.edu	37	chr19	36365411	36365411	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacccgctccccagcacttCcagtccattctgcagactct	7	9	5	20	1	2	1	0	0	2	1	5	1	5	1	6	0	2	3	6	0	0	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr19:36365411C>A	uc002oce.2	+	9	1200	c.1062C>A	c.(1060-1062)TTC>TTA	p.F354L	APLP1_uc010xsz.1_Missense_Mutation_p.F315L|APLP1_uc002ocf.2_Missense_Mutation_p.F354L|APLP1_uc002ocg.2_Missense_Mutation_p.F257L|APLP1_uc010xta.1_Missense_Mutation_p.F348L	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	354	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCAGCACTTCCAGTCCATTC	0.617													52	129					3.50607e-19	2.16799e-18	1	0	A	36365411	A	A	36365411	3	1	196	1	0	0	0	0	1	0	0	0	778	854	30	2	1096	2	APLP1	19	36365411	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	327715	36365411	22763572	134	36206											
LTBP4	8425	broad.mit.edu	37	chr19	41129882	41129882	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaaccggcctgtgagggcGgccgctgtgtcaacactgtg	7	7	16	11	3	1	1	1	1	0	0	1	2	1	2	3	4	2	1	3	4	2	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr19:41129882G>A	uc002ooh.1	+	30	3928	c.3928G>A	c.(3928-3930)GGC>AGC	p.G1310S	LTBP4_uc002oog.1_Missense_Mutation_p.G1273S|LTBP4_uc002ooi.1_Missense_Mutation_p.G1243S|LTBP4_uc002ooj.1_Missense_Mutation_p.G183S|LTBP4_uc002ook.1_Missense_Mutation_p.G444S|LTBP4_uc002ool.1_Missense_Mutation_p.G322S|LTBP4_uc010xvp.1_Missense_Mutation_p.G70S	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1310	EGF-like 14; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGTGAGGGCGGCCGCTGTGT	0.602													9	32					0	0	0	0	A	41129882	A	A	41129882	3	1	196	1	0	0	0	0	1	0	0	0	9126	1116	39	1	4334	1	LTBP4	19	41129882	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	4764471	41129882	17999101	135	36207											
ZC3H4	23211	broad.mit.edu	37	chr19	47570690	47570690	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtcccgcagagggtgcccGgggagtgggtccaggggaat	6	5	21	9	2	0	1	0	0	0	1	2	3	2	3	3	7	1	1	3	7	1	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr19:47570690G>A	uc002pga.3	-	15	2873	c.2835C>T	c.(2833-2835)CCC>CCT	p.P945P	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	945							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GAGGGTGCCCGGGGAGTGGGT	0.677													37	185					0	0	0	0	A	47570690	A	A	47570690	2	1	196	1	0	0	0	0	0	0	0	1	17637	1103	39	1		1	ZC3H4	19	47570690	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	6440808	47570690	11558293	136	36208											
ZNF677	342926	broad.mit.edu	37	chr19	53740463	53740463	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctctccagtatggattttcTtatgctgagtaagatttgaa	10	17	8	6	0	2	3	0	2	2	1	4	4	3	4	1	1	1	3	1	1	4	6			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr19:53740463T>G	uc002qbf.1	-	5	1702	c.1517A>C	c.(1516-1518)AAG>ACG	p.K506T	ZNF677_uc002qbg.1_Missense_Mutation_p.K506T	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	506	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		ATGGATTTTCTTATGCTGAGT	0.388													5	74					0	0	0	0	G	53740463	G	G	53740463	3	3	196	1	0	0	0	0	1	0	0	0	18151	1609	56	5	241	5	ZNF677	19	53740463	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	6169773	53740463	5388520	137	36209											
C20orf12	55184	broad.mit.edu	37	chr20	18371073	18371073	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttccttcccccgtgggtcCgacttccttcagcaggagtc	4	12	9	16	2	2	0	1	0	1	0	7	2	6	1	5	2	1	1	5	2	0	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr20:18371073C>T	uc010zsa.1	-	18	2106	c.1897G>A	c.(1897-1899)GGA>AGA	p.G633R	C20orf12_uc010zrz.1_Missense_Mutation_p.G152R|C20orf12_uc002wqp.3_Missense_Mutation_p.G324R|C20orf12_uc002wqr.3_RNA|C20orf12_uc002wqs.3_Missense_Mutation_p.G500R|C20orf12_uc002wqq.3_Missense_Mutation_p.G614R	NM_001099407	NP_001092877	Q9NVP4	CT012_HUMAN	hypothetical protein LOC55184	441	ANK 1.					intracellular	zinc ion binding			ovary(1)	1		Myeloproliferative disorder(85;0.0122)				CCCGTGGGTCCGACTTCCTTC	0.488													16	130					0	0	0	0	T	18371073	T	T	18371073	3	4	196	1	0	0	0	0	1	0	0	0	2095	661	23	1	434	1	C20orf12	20	18371073	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08		18371073	44654447	138	36210											
PTPRT	11122	broad.mit.edu	37	chr20	40710552	40710552	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accatgttggatttgttgttAcgcagtgttttcacgatgtg	7	17	11	6	2	1	0	1	0	0	0	1	2	1	1	1	1	1	5	1	1	1	6			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr20:40710552A>G	uc002xkg.2	-	30	4426	c.4242T>C	c.(4240-4242)CGT>CGC	p.R1414R	PTPRT_uc010ggj.2_Silent_p.R1433R|PTPRT_uc010ggi.2_Silent_p.R617R	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1414	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATTTGTTGTTACGCAGTGTTT	0.502													27	103					0	0	0	0	G	40710552	G	G	40710552	2	3	196	1	0	0	0	0	0	0	0	1	12877	378	14	5		5	PTPRT	20	40710552	Silent	SNP	A	TCGA-CV-6937-01A-11D-2012-08	22339479	40710552	22314968	139	36211											
TUBB1	81027	broad.mit.edu	37	chr20	57598597	57598597	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacctagaacctgggacgatGgacagcattcgatctagcaa	13	7	11	10	2	1	1	0	0	1	1	2	6	1	3	2	2	3	2	2	2	4	3	rs147465283		TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr20:57598597G>A	uc002yak.2	+	3	488	c.219G>A	c.(217-219)ATG>ATA	p.M73I		NM_030773	NP_110400	Q9H4B7	TBB1_HUMAN	beta tubulin 1, class VI	73					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			ovary(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	CTGGGACGATGGACAGCATTC	0.463													30	106					0	0	0	0	A	57598597	A	A	57598597	3	1	196	1	0	0	0	0	1	0	0	0	16821	1348	47	4	229	4	TUBB1	20	57598597	Missense_Mutation	SNP	G	TCGA-CV-6937-01A-11D-2012-08	16888045	57598597	5426923	140	36212											
SERPIND1	3053	broad.mit.edu	37	chr22	21134259	21134259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttgggtacacactgcggtCagtcaatgacctttatatcc	9	14	8	10	1	2	1	2	1	0	0	3	1	3	1	2	2	2	1	2	2	4	6			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr22:21134259C>T	uc002ztb.1	+	2	726	c.659C>T	c.(658-660)TCA>TTA	p.S220L	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.S248L	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	220					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	ACACTGCGGTCAGTCAATGAC	0.433													90	321					0	0	0	0	T	21134259	T	T	21134259	3	4	196	1	0	0	0	0	1	0	0	0	14175	838	29	2	661	2	SERPIND1	22	21134259	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08		21134259	30170307	141	36213			1	52		6	5	221	N	C	5.811103e-14
SERPIND1	3053	broad.mit.edu	37	chr22	21134279	21134279	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcaatgacctttatatcCagaagcagtttccaatcctg	12	12	6	11	0	1	2	1	1	0	1	4	2	4	2	4	0	1	2	4	0	5	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr22:21134279C>T	uc002ztb.1	+	2	746	c.679C>T	c.(679-681)CAG>TAG	p.Q227*	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Nonsense_Mutation_p.Q255*	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	227					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	CCTTTATATCCAGAAGCAGTT	0.438													135	319					0	0	0	0	T	21134279	T	T	21134279	4	4	196	1	0	0	0	0	0	1	0	0	14175	595	21	4	681	4	SERPIND1	22	21134279	Nonsense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	20	21134279	30170287	142	36214			1	52		6	5	221	N	C	5.811103e-14
SERPIND1	3053	broad.mit.edu	37	chr22	21134359	21134359	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggcccagatagctgacttCtcagaccctgccttcatatc	9	10	8	14	0	2	3	2	1	1	2	4	4	2	3	3	1	2	1	3	1	2	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr22:21134359C>T	uc002ztb.1	+	2	826	c.759C>T	c.(757-759)TTC>TTT	p.F253F	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Silent_p.F281F	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	253					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	TAGCTGACTTCTCAGACCCTG	0.433													389	575					0	0	0	0	T	21134359	T	T	21134359	2	4	196	1	0	0	0	0	0	0	0	1	14175	912	32	2		2	SERPIND1	22	21134359	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	80	21134359	30170207	143	36215			1	52		6	5	221	N	C	5.811103e-14
SERPIND1	3053	broad.mit.edu	37	chr22	21134379	21134379	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagaccctgccttcatatCaaaaaccaacaaccacatca	16	7	2	16	0	4	1	4	0	0	1	4	1	4	1	4	0	4	0	4	0	5	2	rs76882693		TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr22:21134379C>G	uc002ztb.1	+	2	846	c.779C>G	c.(778-780)TCA>TGA	p.S260*	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Nonsense_Mutation_p.S288*	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	260					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	GCCTTCATATCAAAAACCAAC	0.438													404	531					0	0	0	0	G	21134379	G	G	21134379	4	3	196	1	0	0	0	0	0	1	0	0	14175	838	29	2	781	2	SERPIND1	22	21134379	Nonsense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	20	21134379	30170187	144	36216			1	52		6	5	221	N	C	5.811103e-14
SERPIND1	3053	broad.mit.edu	37	chr22	21134470	21134470	+	Silent	SNP	C	T	T																															gctacccagatgatgattctCaactgcatctacttcaaagg																										TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr22:21134470C>T	uc002ztb.1	+	2	937	c.870C>T	c.(868-870)CTC>CTT	p.L290L	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Silent_p.L318L	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	290					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	TGATGATTCTCAACTGCATCT	0.418													381	542					0	0	0	0	T	21134470	T	T	21134470	2	4	196	1	0	0	0	0	0	0	0	1	14175	813	29	2		2	SERPIND1	22	21134470	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	91	21134470	30170096	145	36217	69	2	1	52		6	5	221	N	C	5.811103e-14
SERPIND1	3053	broad.mit.edu	37	chr22	21134479	21134479	+	Silent	SNP	C	T	T																															atgatgattctcaactgcatCtacttcaaaggtaagaggca																										TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr22:21134479C>T	uc002ztb.1	+	2	946	c.879C>T	c.(877-879)ATC>ATT	p.I293I	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Silent_p.I321I	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	293					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	TCAACTGCATCTACTTCAAAG	0.423													370	542					0	0	0	0	T	21134479	T	T	21134479	2	4	196	1	0	0	0	0	0	0	0	1	14175	903	32	2		2	SERPIND1	22	21134479	Silent	SNP	C	TCGA-CV-6937-01A-11D-2012-08	9	21134479	30170087	146	36218	69	2	1	52		6	5	221	N	C	5.811103e-14
SUSD2	56241	broad.mit.edu	37	chr22	24582117	24582117	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgcgggcccagcccgggacGatgtccaacggtgaggccag	7	3	17	14	5	0	1	0	1	0	0	1	3	1	2	4	4	2	0	4	4	1	0			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr22:24582117G>A	uc002zzn.1	+	9	1517	c.1473G>A	c.(1471-1473)ACG>ACA	p.T491T		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	491	VWFD.|Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						AGCCCGGGACGATGTCCAACG	0.662													4	21					0	0	0	0	A	24582117	A	A	24582117	2	1	196	1	0	0	0	0	0	0	0	1	15474	1045	37	1		1	SUSD2	22	24582117	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	3447638	24582117	26722449	147	36219											
SLC25A17	10478	broad.mit.edu	37	chr22	41215416	41215416	+	5'Flank	DEL	C	-	-																															cgggtcgcggggcgggaaagCgggggggggggggcggctaa																								rs111880788		TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr22:41215416delC	uc003azc.2	-						SLC25A17_uc010gyg.2_5'Flank|SLC25A17_uc011aou.1_5'Flank|SLC25A17_uc003azd.2_5'Flank|SLC25A17_uc011aov.1_5'Flank	NM_006358	NP_006349	O43808	PM34_HUMAN	solute carrier family 25 (mitochondrial carrier;						fatty acid alpha-oxidation	integral to plasma membrane|mitochondrial inner membrane|peroxisomal membrane	adenine nucleotide transmembrane transporter activity|protein binding				0						GGCGGGAAAGCGGGGGGGGGG	0.716											OREG0026586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	41215416	-	-	41215416	6	5	196	0	1	1	0	1	0	0	0	0	14543	783	27	0		0	SLC25A17	22	41215416	5'Flank	DEL	C	TCGA-CV-6937-01A-11D-2012-08	16633299	41215416	10089150	148	36220											
XRCC6	2547	broad.mit.edu	37	chr22	42032124	42032124	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttttttcagtgtatccAaagtgtgtacatcagtaaga	11	18	7	5	0	2	1	2	0	0	1	3	1	3	1	1	0	1	3	1	0	4	8			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr22:42032124A>G	uc003bao.1	+	4	273	c.203A>G	c.(202-204)CAA>CGA	p.Q68R	XRCC6_uc003bap.1_Intron|XRCC6_uc011apc.1_Missense_Mutation_p.Q18R|XRCC6_uc003baq.1_Missense_Mutation_p.Q68R|XRCC6_uc003bar.1_Missense_Mutation_p.Q68R|XRCC6_uc003bas.1_Missense_Mutation_p.Q18R	NM_001469	NP_001460	P12956	XRCC6_HUMAN	ATP-dependent DNA helicase II, 70 kDa subunit	68					DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			skin(2)|ovary(1)|lung(1)|kidney(1)	5						CAGTGTATCCAAAGTGTGTAC	0.338								Direct_reversal_of_damage|NHEJ					7	34					0	0	0	0	G	42032124	G	G	42032124	3	3	196	1	0	0	0	0	1	0	0	0	17525	130	5	5	213	5	XRCC6	22	42032124	Missense_Mutation	SNP	A	TCGA-CV-6937-01A-11D-2012-08	816708	42032124	9272442	149	36221											
TUBGCP6	85378	broad.mit.edu	37	chr22	50664276	50664276	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caccctctccatgcgcccaaCgtagacggcacagtccttct	8	8	7	18	3	2	1	0	0	2	1	4	1	3	1	4	1	2	2	4	1	2	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chr22:50664276C>T	uc003bkb.1	-	10	2442	c.1930G>A	c.(1930-1932)GTT>ATT	p.V644I	TUBGCP6_uc010har.1_Missense_Mutation_p.V644I|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'Flank|TUBGCP6_uc003bkd.1_5'UTR	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	644					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		ATGCGCCCAACGTAGACGGCA	0.607													5	36					0	0	0	0	T	50664276	T	T	50664276	3	4	196	1	0	0	0	0	1	0	0	0	16838	536	19	1	3593	1	TUBGCP6	22	50664276	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	8632152	50664276	640290	150	36222											
CRLF2	64109	broad.mit.edu	37	chrX	1325403	1325403	+	RNA	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaatagagaatgtcgtctCgctgctctgcgtctaggagg	10	10	13	8	3	3	2	0	0	3	2	5	4	3	3	0	2	2	2	0	2	4	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chrX:1325403C>A	uc004cpm.1	-	3		c.272G>T						Q9HC73	CRLF2_HUMAN	Homo sapiens mRNA for IL-XR, complete cds.							extracellular region|integral to membrane|plasma membrane	receptor activity			haematopoietic_and_lymphoid_tissue(7)	7		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AATGTCGTCTCGCTGCTCTGC	0.507			Mis|T	P2RY8|IGH@	B-ALL|Downs associated ALL								5	143					0.00116845	0.0064862	1	0	A	1325403	A	A	1325403	1	1	196	0	1	0	0	0	0	0	0	0	3902	884	31	3		3	CRLF2	23	1325403	RNA	SNP	C	TCGA-CV-6937-01A-11D-2012-08		1325403	153945157	151	36223											
ARSF	416	broad.mit.edu	37	chrX	3030221	3030221	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttctcctccaggtgggtCagtttggaaggctcactatg	6	14	11	10	0	3	0	2	0	1	0	5	1	4	1	2	4	0	2	2	4	2	4			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chrX:3030221C>T	uc004cre.1	+	11	1618	c.1397C>T	c.(1396-1398)TCA>TTA	p.S466L	ARSF_uc004crf.1_Missense_Mutation_p.S466L	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	466						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ccAGGTGGGTCAGTTTGGAAG	0.284													25	28					0	0	0	0	T	3030221	T	T	3030221	3	4	196	1	0	0	0	0	1	0	0	0	993	838	29	2	1435	2	ARSF	23	3030221	Missense_Mutation	SNP	C	TCGA-CV-6937-01A-11D-2012-08	1704818	3030221	152240339	152	36224											
TLR8	51311	broad.mit.edu	37	chrX	12937993	12937993	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtggtgcttcaattaatatAgatcgttttgcttttcaaaa	11	17	8	5	1	2	1	2	0	0	1	3	1	2	1	0	2	2	3	0	2	6	8			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chrX:12937993A>T	uc004cve.2	+	2	902	c.834A>T	c.(832-834)ATA>ATT	p.I278I	TLR8_uc004cvd.2_Silent_p.I296I	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	278	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						CAATTAATATAGATCGTTTTG	0.408													12	47					0	0	0	0	T	12937993	T	T	12937993	2	4	196	1	0	0	0	0	0	0	0	1	16023	410	15	5		5	TLR8	23	12937993	Silent	SNP	A	TCGA-CV-6937-01A-11D-2012-08	9907772	12937993	142332567	153	36225											
FAM47C	442444	broad.mit.edu	37	chrX	37026544	37026544	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcatggactccacgccctggTactgtgacaaaccgccttcc	8	8	9	16	2	0	1	0	1	0	0	2	2	2	2	5	2	2	2	5	2	2	2			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chrX:37026544T>C	uc004ddl.1	+	1	75	c.61T>C	c.(61-63)TAC>CAC	p.Y21H		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	21										ovary(3)	3						CACGCCCTGGTACTGTGACAA	0.657													12	13					0	0	0	0	C	37026544	C	C	37026544	3	2	196	1	0	0	0	0	1	0	0	0	5603	1638	57	5	63	5	FAM47C	23	37026544	Missense_Mutation	SNP	T	TCGA-CV-6937-01A-11D-2012-08	24088551	37026544	118244016	154	36226											
ARHGEF9	23229	broad.mit.edu	37	chrX	62917122	62917122	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatcttcaatgttcccaaaGattaccttcagttgctcgtc	10	15	5	11	1	3	1	2	0	1	1	6	1	4	1	2	0	2	3	2	0	4	6			TCGA-CV-6937-01A-11D-2012-08	TCGA-CV-6937-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c78a20e-150f-4c12-8abe-b941f90e730f	9d1e96e0-810f-4f72-a622-c95907643627	g.chrX:62917122G>T	uc004dvl.2	-	4	1283	c.444C>A	c.(442-444)ATC>ATA	p.I148I	ARHGEF9_uc004dvj.1_Silent_p.I37I|ARHGEF9_uc004dvk.1_Silent_p.I10I|ARHGEF9_uc011mos.1_Silent_p.I127I|ARHGEF9_uc004dvm.1_Silent_p.I127I|ARHGEF9_uc011mot.1_Silent_p.I95I|ARHGEF9_uc004dvn.2_Silent_p.I155I	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	148	DH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						TGTTCCCAAAGATTACCTTCA	0.468													9	18					3.86212e-05	0.000223272	1	0	T	62917122	T	T	62917122	2	4	196	1	0	0	0	0	0	0	0	1	912	932	33	2		2	ARHGEF9	23	62917122	Silent	SNP	G	TCGA-CV-6937-01A-11D-2012-08	25890578	62917122	92353438	155	36227											
ERRFI1	54206	broad.mit.edu	37	chr1	8074054	8074054	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgatttgtccacacccaCggaagcttcgcctgccagga	9	9	10	13	2	0	1	0	1	0	0	2	3	1	3	4	2	2	2	4	2	1	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:8074054C>T	uc001aoz.2	-	4	854	c.605G>A	c.(604-606)CGT>CAT	p.R202H	ERRFI1_uc001apa.1_Missense_Mutation_p.R127H	NM_018948	NP_061821	Q9UJM3	ERRFI_HUMAN	mitogen-inducible gene 6 protein	202					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			ovary(1)	1	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		TCCACACCCACGGAAGCTTCG	0.443													7	38					0	0	0	0	T	8074054	T	T	8074054	3	4	197	1	0	0	0	0	1	0	0	0	5268	536	19	1	787	1	ERRFI1	1	8074054	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		8074054	241176567	1	36228											
CA6	765	broad.mit.edu	37	chr1	9022705	9022705	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttctcatctggccaacatCaagtacccaggtaagggaag	13	9	9	10	0	3	0	2	0	2	0	4	1	3	1	2	3	2	2	2	3	5	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:9022705C>T	uc001apm.2	+	5	585	c.561C>T	c.(559-561)ATC>ATT	p.I187I	CA6_uc009vmn.2_Silent_p.I127I	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	187					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		TGGCCAACATCAAGTACCCAG	0.507													12	66					0	0	0	0	T	9022705	T	T	9022705	2	4	197	1	0	0	0	0	0	0	0	1	2533	816	29	2		2	CA6	1	9022705	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	948651	9022705	240227916	2	36229											
VPS13D	55187	broad.mit.edu	37	chr1	12416557	12416557	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagtcctctcttattctgctAtgctgacaaagagcagccaa	11	11	8	11	0	2	2	0	1	2	1	4	3	3	2	2	0	4	3	2	0	4	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:12416557A>G	uc001atv.2	+	49	10115	c.9974A>G	c.(9973-9975)TAT>TGT	p.Y3325C	VPS13D_uc001atw.2_Missense_Mutation_p.Y3300C|VPS13D_uc001atx.2_Missense_Mutation_p.Y2512C	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3324					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTATTCTGCTATGCTGACAAA	0.468													22	77					0	0	0	0	G	12416557	G	G	12416557	3	3	197	1	0	0	0	0	1	0	0	0	17260	449	16	5	10164	5	VPS13D	1	12416557	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	3393852	12416557	236834064	3	36230											
DHDDS	79947	broad.mit.edu	37	chr1	26769228	26769228	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctcccctctcagactctgCggtggtgtttgaacctgggc	4	13	11	13	1	3	2	1	1	3	1	5	2	3	2	3	3	2	1	3	3	1	2	rs148606976		TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:26769228C>T	uc001bml.2	+	4	308	c.187C>T	c.(187-189)CGG>TGG	p.R63W	DHDDS_uc001bmk.2_Missense_Mutation_p.R63W|DHDDS_uc001bmm.2_5'UTR|DHDDS_uc001bmn.2_Missense_Mutation_p.R63W|DHDDS_uc010ofd.1_Missense_Mutation_p.R63W	NM_205861	NP_995583	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase isoform b	63							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(3)	3		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		TCAGACTCTGCGGTGGTGTTT	0.493													46	119					0	0	0	0	T	26769228	T	T	26769228	3	4	197	1	0	0	0	0	1	0	0	0	4500	759	27	1	197	1	DHDDS	1	26769228	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	14352671	26769228	222481393	4	36231											
PHC2	1912	broad.mit.edu	37	chr1	33795788	33795788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtctgagtggaaaagtcccaCccgtttggtgcatcccacgt	8	10	11	12	2	1	1	0	1	1	0	3	2	3	2	3	2	1	2	3	2	2	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:33795788C>T	uc001bxg.1	-	12	2083	c.2029G>A	c.(2029-2031)GTG>ATG	p.V677M	PHC2_uc001bxh.1_Missense_Mutation_p.V649M|PHC2_uc009vuh.1_Missense_Mutation_p.V678M|PHC2_uc001bxe.1_Missense_Mutation_p.V142M|PHC2_uc001bxf.1_Missense_Mutation_p.V92M	NM_198040	NP_932157	Q8IXK0	PHC2_HUMAN	polyhomeotic-like 2 isoform a	677					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AAAAGTCCCACCCGTTTGGTG	0.582													7	61					0	0	0	0	T	33795788	T	T	33795788	3	4	197	1	0	0	0	0	1	0	0	0	11872	507	18	4	559	4	PHC2	1	33795788	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	7026560	33795788	215454833	5	36232											
GFI1	2672	broad.mit.edu	37	chr1	92948573	92948573	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaacggtcccggggctccGccttcgccccgcctgcattt	5	8	10	18	5	0	0	0	0	0	0	3	0	2	0	6	3	2	2	6	3	1	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:92948573G>A	uc001dou.3	-	3	310	c.146C>T	c.(145-147)GCG>GTG	p.A49V	GFI1_uc001dov.3_Missense_Mutation_p.A49V|GFI1_uc001dow.3_Missense_Mutation_p.A49V	NM_001127215	NP_001120687	Q99684	GFI1_HUMAN	growth factor independent 1	49					negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)	1		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		CCGGGGCTCCGCCTTCGCCCC	0.662													12	54					0	0	0	0	A	92948573	A	A	92948573	3	1	197	1	0	0	0	0	1	0	0	0	6376	1087	38	1	1142	1	GFI1	1	92948573	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	59152785	92948573	156302048	6	36233											
TCHH	7062	broad.mit.edu	37	chr1	152083257	152083257	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctccttctcctcctcctcCgggagaaaccgttgttcccg	4	12	8	17	3	1	1	0	0	1	1	7	2	6	1	7	1	2	3	7	1	1	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:152083257C>T	uc001ezp.2	-	2	2436	c.2436G>A	c.(2434-2436)CCG>CCA	p.P812P	TCHH_uc009wne.1_Silent_p.P812P	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	812					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCCTCCTCCGGGAGAAACC	0.701													7	65					0	0	0	0	T	152083257	T	T	152083257	2	4	197	1	0	0	0	0	0	0	0	1	15766	639	23	1		1	TCHH	1	152083257	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	59134684	152083257	97167364	7	36234											
FLG	2312	broad.mit.edu	37	chr1	152279952	152279952	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggatccctgccttcctccActgcttgaccccgggtgtcc	3	11	10	17	1	0	1	0	1	0	0	4	2	4	2	7	2	2	1	7	2	0	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:152279952A>T	uc001ezu.1	-	3	7446	c.7410T>A	c.(7408-7410)AGT>AGA	p.S2470R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2470	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTTCCTCCACTGCTTGACC	0.567									Ichthyosis				36	581					0	0	0	0	T	152279952	T	T	152279952	3	4	197	1	0	0	0	0	1	0	0	0	5954	156	6	5	4779	5	FLG	1	152279952	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	196695	152279952	96970669	8	36235											
ADAM15	8751	broad.mit.edu	37	chr1	155029698	155029698	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacttcagcaactgcagcCgacgggccctggagaaagcc	11	5	12	13	2	1	2	1	1	0	1	1	4	1	2	3	2	6	2	3	2	3	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:155029698C>T	uc001fgr.1	+	12	1284	c.1183C>T	c.(1183-1185)CGA>TGA	p.R395*	ADAM15_uc001fgq.1_Nonsense_Mutation_p.R80*|ADAM15_uc010pet.1_Nonsense_Mutation_p.R379*|ADAM15_uc010peu.1_Nonsense_Mutation_p.R412*|ADAM15_uc001fgt.1_Nonsense_Mutation_p.R395*|ADAM15_uc010pev.1_Nonsense_Mutation_p.R405*|ADAM15_uc001fgs.1_Nonsense_Mutation_p.R395*|ADAM15_uc001fgu.1_Nonsense_Mutation_p.R395*|ADAM15_uc001fgw.1_Nonsense_Mutation_p.R395*|ADAM15_uc001fgv.1_Nonsense_Mutation_p.R395*|ADAM15_uc001fgx.1_Nonsense_Mutation_p.R395*|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	395	Peptidase M12B.|Extracellular (Potential).				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CAACTGCAGCCGACGGGCCCT	0.632													8	40					0	0	0	0	T	155029698	T	T	155029698	4	4	197	1	0	0	0	0	0	1	0	0	237	644	23	1	1229	1	ADAM15	1	155029698	Nonsense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	2749746	155029698	94220923	9	36236											
PMF1	11243	broad.mit.edu	37	chr1	156206091	156206091	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccctccaggcgccccagcggGatcccagagaaggatctgca	9	4	12	16	2	1	1	0	0	1	1	3	4	3	3	5	3	2	1	5	3	1	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:156206091G>T	uc001fnq.2	+	4	404	c.381G>T	c.(379-381)GGG>GGT	p.G127G	PMF1_uc001fnr.2_Intron|BGLAP_uc001fns.1_Intron	NM_007221	NP_009152	Q6P1K2	PMF1_HUMAN	polyamine-modulated factor 1	127					cell division|chromosome segregation|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytosol|MIS12/MIND type complex|transcription factor complex	leucine zipper domain binding|transcription coactivator activity				0	Hepatocellular(266;0.158)					GCCCCAGCGGGATCCCAGAGA	0.617													9	110					1.76689e-08	2.32162e-08	1	0	T	156206091	T	T	156206091	2	4	197	1	0	0	0	0	0	0	0	1	12188	1161	41	2		2	PMF1	1	156206091	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1176393	156206091	93044530	10	36237											
OLFML2B	25903	broad.mit.edu	37	chr1	161953756	161953756	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttctgtgtgctcaggtcCgcggcattgagcttgctcag	4	13	12	12	2	3	1	2	1	1	0	5	1	5	1	2	2	3	4	2	2	0	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:161953756C>T	uc001gbu.2	-	8	2386	c.1962G>A	c.(1960-1962)GCG>GCA	p.A654A	OLFML2B_uc001gbt.2_Silent_p.A137A|OLFML2B_uc010pkq.1_Silent_p.A655A	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	654	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TGCTCAGGTCCGCGGCATTGA	0.582													13	71					0	0	0	0	T	161953756	T	T	161953756	2	4	197	1	0	0	0	0	0	0	0	1	10912	639	23	1		1	OLFML2B	1	161953756	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	5747665	161953756	87296865	11	36238											
PIK3C2B	5287	broad.mit.edu	37	chr1	204394760	204394760	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatctcattgtaggtaggaTtgcaggttttccgggccact	7	13	11	10	1	1	0	1	0	1	0	3	1	2	1	3	4	1	4	3	4	2	6	rs143735929		TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:204394760T>A	uc001haw.2	-	33	5176	c.4697A>T	c.(4696-4698)AAT>ATT	p.N1566I	PIK3C2B_uc010pqv.1_Missense_Mutation_p.N1538I	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1566	C2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GTAGGTAGGATTGCAGGTTTT	0.498													11	59					0	0	0	0	A	204394760	A	A	204394760	3	1	197	1	0	0	0	0	1	0	0	0	11965	1493	52	5	215	5	PIK3C2B	1	204394760	Missense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08	42441004	204394760	44855861	12	36239											
TMCC2	9911	broad.mit.edu	37	chr1	205238928	205238928	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggagggacagtctcaccTggaggactccatggaagacc	12	5	13	11	0	1	1	1	0	1	1	3	6	2	6	3	5	0	0	3	5	2	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:205238928T>C	uc001hbz.1	+	4	2042	c.1598T>C	c.(1597-1599)CTG>CCG	p.L533P	TMCC2_uc010prf.1_Missense_Mutation_p.L455P|TMCC2_uc001hca.2_Missense_Mutation_p.L308P|TMCC2_uc001hcb.1_Missense_Mutation_p.L293P|TMCC2_uc001hcc.1_Missense_Mutation_p.L154P|TMCC2_uc001hcd.2_Missense_Mutation_p.L300P	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	533	Potential.					integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CAGTCTCACCTGGAGGACTCC	0.587													3	144					0	0	0	0	C	205238928	C	C	205238928	3	2	197	1	0	0	0	0	1	0	0	0	16059	1580	55	5	1608	5	TMCC2	1	205238928	Missense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08	844168	205238928	44011693	13	36240											
SLC26A9	115019	broad.mit.edu	37	chr1	205899105	205899105	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaatcaggatctgcaggccgGcggccgtcatgaagccccgg	9	5	14	13	4	3	1	2	1	1	0	3	2	3	2	4	5	2	1	4	5	2	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:205899105G>T	uc001hdq.2	-	6	746	c.632C>A	c.(631-633)GCC>GAC	p.A211D	SLC26A9_uc001hdo.2_5'Flank|SLC26A9_uc001hdp.2_Missense_Mutation_p.A211D	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	211	Helical; (Potential).					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			CTGCAGGCCGGCGGCCGTCAT	0.577													9	47					1.12685e-05	1.44698e-05	1	0	T	205899105	T	T	205899105	3	4	197	1	0	0	0	0	1	0	0	0	14588	1203	42	4	2103	4	SLC26A9	1	205899105	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	660177	205899105	43351516	14	36241											
IRF6	3664	broad.mit.edu	37	chr1	209969692	209969692	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccagcacctggggcctcaCctgggttaatgatcgagccc	7	7	11	16	1	1	1	1	1	0	0	2	2	1	1	6	3	2	2	6	3	1	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:209969692C>G	uc001hhq.1	-	4	642	c.379_splice	c.e4+1	p.G127_splice	IRF6_uc010psm.1_Splice_Site_p.G32_splice|IRF6_uc009xct.1_Splice_Site_p.G127_splice	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6						cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		TGGGGCCTCACCTGGGTTAAT	0.512										HNSCC(57;0.16)			6	53					0	0	0	0	G	209969692	G	G	209969692	5	3	197	1	0	0	0	0	0	0	1	0	7873	521	18	4	1047	4	IRF6	1	209969692	Splice_Site	SNP	C	TCGA-CV-6938-01A-11D-1912-08	4070587	209969692	39280929	15	36242											
VASH2	79805	broad.mit.edu	37	chr1	213146032	213146032	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggggatttactgcaatggccGctatggctcattgggcatga	8	11	14	8	1	1	1	1	1	0	0	1	2	1	2	1	5	2	4	1	5	3	4	rs150945050		TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:213146032G>A	uc001hjy.2	+	5	812	c.608G>A	c.(607-609)CGC>CAC	p.R203H	VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Missense_Mutation_p.R138H|VASH2_uc010ptn.1_Missense_Mutation_p.R99H|VASH2_uc001hjw.2_Missense_Mutation_p.R159H	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3	203					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		TGCAATGGCCGCTATGGCTCA	0.502													10	82					0	0	0	0	A	213146032	A	A	213146032	3	1	197	1	0	0	0	0	1	0	0	0	17194	1087	38	1	626	1	VASH2	1	213146032	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	3176340	213146032	36104589	16	36243											
MARK1	4139	broad.mit.edu	37	chr1	220824023	220824023	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatgtctgtgaaaggaccaCagatcgatacgtagcattgc	13	10	10	8	2	1	2	0	1	1	1	2	4	1	3	1	1	3	2	1	1	4	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:220824023C>T	uc001hmn.3	+	14	2129	c.1532C>T	c.(1531-1533)ACA>ATA	p.T511I	MARK1_uc009xdw.2_Missense_Mutation_p.T511I|MARK1_uc010pun.1_Missense_Mutation_p.T511I|MARK1_uc001hmm.3_Missense_Mutation_p.T489I	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	511					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		GAAAGGACCACAGATCGATAC	0.378													14	101					0	0	0	0	T	220824023	T	T	220824023	3	4	197	1	0	0	0	0	1	0	0	0	9365	478	17	4	1586	4	MARK1	1	220824023	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	7677991	220824023	28426598	17	36244											
AGT	183	broad.mit.edu	37	chr1	230841942	230841942	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagggagaagcccttcatCttccctgaaatccagacagg	12	7	10	12	0	2	3	1	1	1	2	4	4	4	3	3	2	2	1	3	2	2	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:230841942C>T	uc001hty.3	-	3	1369	c.861G>A	c.(859-861)AAG>AAA	p.K287K	AGT_uc009xfe.2_Silent_p.K287K|AGT_uc009xff.2_Silent_p.K259K	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	287					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	AGCCCTTCATCTTCCCTGAAA	0.607													6	39					0	0	0	0	T	230841942	T	T	230841942	2	4	197	1	0	0	0	0	0	0	0	1	399	912	32	2		2	AGT	1	230841942	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	10017919	230841942	18408679	18	36245											
AGT	183	broad.mit.edu	37	chr1	230846071	230846071	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agacaggaccttgtgcgcatCcagccgggaggtgcagttct	8	8	14	11	2	1	1	0	0	1	1	2	3	2	3	3	3	3	3	3	3	0	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:230846071C>T	uc001hty.3	-	2	1034	c.526G>A	c.(526-528)GAT>AAT	p.D176N	AGT_uc009xfe.2_Missense_Mutation_p.D176N|AGT_uc009xff.2_Missense_Mutation_p.D148N	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	176					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	TTGTGCGCATCCAGCCGGGAG	0.627													8	66					0	0	0	0	T	230846071	T	T	230846071	3	4	197	1	0	0	0	0	1	0	0	0	399	855	30	2	947	2	AGT	1	230846071	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	4129	230846071	18404550	19	36246											
ADSS	159	broad.mit.edu	37	chr1	244579342	244579342	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caactccaactttgatttccGtaaacatgtccaaaatatcc	14	12	3	12	1	0	1	0	1	0	0	4	1	4	1	4	0	3	1	4	0	7	4	rs147946123	by1000genomes	TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:244579342G>A	uc001iaj.2	-	11	1403	c.1109C>T	c.(1108-1110)ACG>ATG	p.T370M		NM_001126	NP_001117	P30520	PURA2_HUMAN	adenylosuccinate synthase	370					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	TTTGATTTCCGTAAACATGTC	0.338													3	31					0	0	0	0	A	244579342	A	A	244579342	3	1	197	1	0	0	0	0	1	0	0	0	347	1145	40	1	273	1	ADSS	1	244579342	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	13733271	244579342	4671279	20	36247											
AHCTF1	25909	broad.mit.edu	37	chr1	247014644	247014644	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtcaatagtatcaaaattgTactgaagcttaagtgttcca	14	13	8	6	0	2	1	2	1	0	0	3	1	3	1	1	1	2	4	1	1	8	6			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr1:247014644T>A	uc001ibu.1	-	32	4671	c.4664A>T	c.(4663-4665)TAC>TTC	p.Y1555F	AHCTF1_uc001ibv.1_Missense_Mutation_p.Y1564F|AHCTF1_uc009xgs.1_Missense_Mutation_p.Y416F|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1555	Mediates transcriptional activity (By similarity).|Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			ATCAAAATTGTACTGAAGCTT	0.378													10	74					0	0	0	0	A	247014644	A	A	247014644	3	1	197	1	0	0	0	0	1	0	0	0	408	1638	57	5	2152	5	AHCTF1	1	247014644	Missense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08	2435302	247014644	2235977	21	36248											
ERLEC1	27248	broad.mit.edu	37	chr2	54041718	54041718	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaaatggagatatttgtgAtataactgacaaaccaagac	17	10	9	5	0	0	4	0	2	0	2	0	6	0	5	1	2	2	0	1	2	6	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:54041718A>T	uc002rxl.2	+	12	1545	c.1265A>T	c.(1264-1266)GAT>GTT	p.D422V	ASB3_uc002rxi.3_Intron|ERLEC1_uc002rxm.2_Intron|ERLEC1_uc002rxn.2_Missense_Mutation_p.D368V	NM_015701	NP_056516	Q96DZ1	ERLEC_HUMAN	erlectin isoform 1	422					ER-associated protein catabolic process	endoplasmic reticulum lumen	glycoprotein binding|protein binding			ovary(2)	2						GATATTTGTGATATAACTGAC	0.318													3	29					0	0	0	0	T	54041718	T	T	54041718	3	4	197	1	0	0	0	0	1	0	0	0	5255	333	12	5	1311	5	ERLEC1	2	54041718	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08		54041718	189157655	22	36249											
ANTXR1	84168	broad.mit.edu	37	chr2	69472570	69472570	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccccaggctccacctcccAacagggcacctcctccctcc	6	6	5	24	0	0	0	0	0	0	0	6	0	6	0	9	2	1	2	9	2	1	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:69472570A>G	uc002sfg.2	+	18	2004	c.1648A>G	c.(1648-1650)AAC>GAC	p.N550D		NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	550	Cytoplasmic (Potential).|Pro-rich.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						tccacctcccaacagggcacc	0.169									Familial_Infantile_Hemangioma				6	54					0	0	0	0	G	69472570	G	G	69472570	3	3	197	1	0	0	0	0	1	0	0	0	711	130	5	5	1795	5	ANTXR1	2	69472570	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	15430852	69472570	173726803	23	36250											
PROM2	150696	broad.mit.edu	37	chr2	95942354	95942354	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcctaggagctgcaggccGtggcacagcaattctccctg	7	9	12	13	1	1	0	0	0	1	0	2	1	1	1	3	3	4	4	3	3	2	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:95942354G>A	uc002suh.1	+	5	764	c.631G>A	c.(631-633)GTG>ATG	p.V211M	PROM2_uc002sui.2_Missense_Mutation_p.V211M|PROM2_uc002suj.2_Translation_Start_Site|PROM2_uc002suk.2_Missense_Mutation_p.V211M|PROM2_uc002sul.2_Intron	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	211	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GCTGCAGGCCGTGGCACAGCA	0.647													7	57					0	0	0	0	A	95942354	A	A	95942354	3	1	197	1	0	0	0	0	1	0	0	0	12618	1145	40	1	649	1	PROM2	2	95942354	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	26469784	95942354	147257019	24	36251											
CNNM4	26504	broad.mit.edu	37	chr2	97427064	97427064	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaagtccaccagctgcctcGagctcaccaaggacctggtc	10	6	9	16	1	1	0	1	0	0	0	4	2	2	1	5	2	3	2	5	2	2	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:97427064G>A	uc002swx.2	+	1	426	c.328G>A	c.(328-330)GAG>AAG	p.E110K		NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	110					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|ovary(1)	3						CAGCTGCCTCGAGCTCACCAA	0.632													10	53					0	0	0	0	A	97427064	A	A	97427064	3	1	197	1	0	0	0	0	1	0	0	0	3630	1059	37	1	330	1	CNNM4	2	97427064	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1484710	97427064	145772309	25	36252											
VWA3B	200403	broad.mit.edu	37	chr2	98779314	98779314	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgctgtgtctccccttttagGagctggagtcagagaggacg	7	11	14	9	1	2	1	1	0	1	1	3	5	2	4	2	3	2	2	2	3	1	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:98779314G>C	uc002syo.2	+	8	1253	c.989G>C	c.(988-990)GGA>GCA	p.G330A	VWA3B_uc010yvh.1_Missense_Mutation_p.G180A|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_5'UTR|VWA3B_uc002sym.2_Missense_Mutation_p.G330A|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_5'UTR	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	330										ovary(3)|large_intestine(2)|skin(1)	6						CCCCTTTTAGGAGCTGGAGTC	0.612													5	32					0	0	0	0	C	98779314	C	C	98779314	3	2	197	1	0	0	0	0	1	0	0	0	17309	1188	41	2	1015	2	VWA3B	2	98779314	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1352250	98779314	144420059	26	36253											
LRP1B	53353	broad.mit.edu	37	chr2	141130669	141130669	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacactgaccattggaacacCggaactgatctttggaacaa	14	9	8	10	1	1	2	0	2	1	0	1	5	1	5	2	3	4	0	2	3	5	3	rs145915063		TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:141130669C>T	uc002tvj.1	-	69	11648	c.10676G>A	c.(10675-10677)CGG>CAG	p.R3559Q		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3559	Extracellular (Potential).|LDL-receptor class A 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTGGAACACCGGAACTGATC	0.368										TSP Lung(27;0.18)			22	84					0	0	0	0	T	141130669	T	T	141130669	3	4	197	1	0	0	0	0	1	0	0	0	9005	652	23	1	3215	1	LRP1B	2	141130669	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	42351355	141130669	102068704	27	36254											
TTN	7273	broad.mit.edu	37	chr2	179477175	179477175	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccagccttttcgcctgaCgtctctcttttccacaatgt	5	16	6	14	2	2	1	0	1	2	0	5	1	3	1	4	0	2	0	4	0	1	5			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:179477175C>T	uc010zfg.1	-	215	42597	c.42373G>A	c.(42373-42375)GTC>ATC	p.V14125I	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V7820I|TTN_uc010zfi.1_Missense_Mutation_p.V7753I|TTN_uc010zfj.1_Missense_Mutation_p.V7628I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15052							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCGCCTGACGTCTCTCTTT	0.463													6	41					0	0	0	0	T	179477175	T	T	179477175	3	4	197	1	0	0	0	0	1	0	0	0	16803	536	19	1	58004	1	TTN	2	179477175	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	38346506	179477175	63722198	28	36255											
COL5A2	1290	broad.mit.edu	37	chr2	189916125	189916136	+	In_Frame_Del	DEL	CCATGAGAGCCA	-	-																															gtcctcgatctcccacacgcCcatgagagccagggtcccca																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:189916125_189916136delCCATGAGAGCCA	uc002uqk.2	-	42	3116_3127	c.2841_2852delTGGCTCTCATGG	c.(2839-2853)CCTGGCTCTCATGGG>CCG	p.GSHG948del	COL5A2_uc010frx.2_In_Frame_Del_p.GSHG524del	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	948_951					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TCCCACACGCCCATGAGAGCCAGGGTCCCCAC	0.608													---	---	---								-	189916136	-	-	189916125	7	5	197	1	0	1	0	1	0	0	0	0	3712	623	22	0	1699	0	COL5A2	2	189916125	In_Frame_Del	DEL	CCATGAGAGCCA	TCGA-CV-6938-01A-11D-1912-08	10438950	189916125	53283248	29	36256											
DNAH7	56171	broad.mit.edu	37	chr2	196605563	196605563	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tctttctattccaggaagctCcatccagaaataatccgtga	12	12	6	11	1	2	2	0	1	2	1	6	3	6	3	4	1	1	1	4	1	4	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:196605563C>G	uc002utj.3	-	64	11896	c.11795G>C	c.(11794-11796)GGA>GCA	p.G3932A	DNAH7_uc002uti.3_Missense_Mutation_p.G415A	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3932					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CCAGGAAGCTCCATCCAGAAA	0.303													12	82					0	0	0	0	G	196605563	G	G	196605563	3	3	197	1	0	0	0	0	1	0	0	0	4628	855	30	2	287	2	DNAH7	2	196605563	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	6689438	196605563	46593810	30	36257											
CASP8	841	broad.mit.edu	37	chr2	202151199	202151199	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaggcgatgatattctcaCcatcctgactgaagtgaact	12	10	9	10	1	1	5	1	4	1	1	3	6	2	5	2	1	1	0	2	1	3	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:202151199C>T	uc002uxr.1	+	10	1531	c.1322C>T	c.(1321-1323)ACC>ATC	p.T441I	CASP8_uc002uxp.1_Missense_Mutation_p.T458I|CASP8_uc002uxq.1_Missense_Mutation_p.T426I|CASP8_uc002uxt.1_Missense_Mutation_p.T500I|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Missense_Mutation_p.T426I|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Missense_Mutation_p.T357I	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	441					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GATATTCTCACCATCCTGACT	0.413										HNSCC(4;0.00038)			4	30					0	0	0	0	T	202151199	T	T	202151199	3	4	197	1	0	0	0	0	1	0	0	0	2689	507	18	4	1633	4	CASP8	2	202151199	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	5545636	202151199	41048174	31	36258											
AAMP	14	broad.mit.edu	37	chr2	219131638	219131638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccacactttcaagaggcCactcatgtcccctgtggcca	8	9	8	16	0	2	1	2	0	0	1	3	1	3	1	5	2	1	0	5	2	1	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:219131638C>T	uc002vhk.2	-	4	550	c.466G>A	c.(466-468)GGC>AGC	p.G156S	AAMP_uc002vhj.2_Missense_Mutation_p.G137S|AAMP_uc010fvo.2_Missense_Mutation_p.G156S|AAMP_uc002vhl.2_Missense_Mutation_p.G157S	NM_001087	NP_001078	Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	156	WD 2.				angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTCAAGAGGCCACTCATGTCC	0.527													27	69					0	0	0	0	T	219131638	T	T	219131638	3	4	197	1	0	0	0	0	1	0	0	0	17	594	21	4	870	4	AAMP	2	219131638	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	16980439	219131638	24067735	32	36259											
HTR2B	3357	broad.mit.edu	37	chr2	231973514	231973514	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatatcggccaaatgcatccCgaaatgtcttattgaagagg	13	11	9	8	2	1	2	0	1	1	1	3	3	2	2	2	2	1	1	2	2	6	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr2:231973514C>A	uc002vro.2	-	4	1668	c.1163G>T	c.(1162-1164)CGG>CTG	p.R388L	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Missense_Mutation_p.R321L	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	388	Cytoplasmic (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	AAATGCATCCCGAAATGTCTT	0.438													23	101					1.10923e-09	1.47463e-09	1	0	A	231973514	A	A	231973514	3	1	197	1	0	0	0	0	1	0	0	0	7481	652	23	3	286	3	HTR2B	2	231973514	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	12841876	231973514	11225859	33	36260											
OSBPL10	114884	broad.mit.edu	37	chr3	31712335	31712335	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcgtgtggaatatcactgTcgctgagtacccagtcttgg	7	13	11	10	2	2	1	1	1	1	0	4	2	2	2	1	2	1	2	1	2	3	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr3:31712335T>C	uc003cev.2	-	10	2248	c.1867A>G	c.(1867-1869)ACA>GCA	p.T623A	OSBPL10_uc003ceu.1_Missense_Mutation_p.T380A|OSBPL10_uc011axf.1_Missense_Mutation_p.T559A	NM_017784	NP_060254	Q9BXB5	OSB10_HUMAN	oxysterol-binding protein-like protein 10	623					lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)		AATATCACTGTCGCTGAGTAC	0.547													12	130					0	0	0	0	C	31712335	C	C	31712335	3	2	197	1	0	0	0	0	1	0	0	0	11329	1667	58	5	443	5	OSBPL10	3	31712335	Missense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08		31712335	166310095	34	36261											
CTNNB1	1499	broad.mit.edu	37	chr3	41275708	41275708	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgagcagggtgccattccaCgactagttcagttgcttgtt	7	13	12	9	1	1	1	1	1	0	0	2	2	2	1	2	1	3	5	2	1	1	6			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr3:41275708C>T	uc010hia.1	+	11	1759	c.1603C>T	c.(1603-1605)CGA>TGA	p.R535*	CTNNB1_uc003ckp.2_Nonsense_Mutation_p.R535*|CTNNB1_uc003ckq.2_Nonsense_Mutation_p.R535*|CTNNB1_uc003ckr.2_Nonsense_Mutation_p.R535*|CTNNB1_uc011azf.1_Nonsense_Mutation_p.R528*|CTNNB1_uc011azg.1_Nonsense_Mutation_p.R463*|CTNNB1_uc003cks.2_3'UTR|CTNNB1_uc003ckt.1_5'Flank	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	535	ARM 10.				adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TGCCATTCCACGACTAGTTCA	0.488		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				12	81					0	0	0	0	T	41275708	T	T	41275708	4	4	197	1	0	0	0	0	0	1	0	0	4033	528	19	1	1637	1	CTNNB1	3	41275708	Nonsense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	9563373	41275708	156746722	35	36262											
CTNNB1	1499	broad.mit.edu	37	chr3	41277959	41277960	+	Frame_Shift_Del	DEL	AG	-	-																															ggagccacagctcctctgacAgagttacttcactctaggaa																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr3:41277959_41277960delAG	uc010hia.1	+	13	2079_2080	c.1923_1924delAG	c.(1921-1926)ACAGAGfs	p.T641fs	CTNNB1_uc003ckp.2_Frame_Shift_Del_p.T641fs|CTNNB1_uc003ckq.2_Frame_Shift_Del_p.T641fs|CTNNB1_uc003ckr.2_Frame_Shift_Del_p.T641fs|CTNNB1_uc011azf.1_Frame_Shift_Del_p.T634fs|CTNNB1_uc011azg.1_Frame_Shift_Del_p.T569fs|CTNNB1_uc003cks.2_3'UTR|CTNNB1_uc003ckt.1_Frame_Shift_Del_p.T76fs	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	641_642	ARM 12.				adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.E632_S681>SV(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	CTCCTCTGACAGAGTTACTTCA	0.465		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				---	---	---								-	41277960	-	-	41277959	7	5	197	1	0	1	0	1	0	0	0	0	4033	175	7	0	1965	0	CTNNB1	3	41277959	Frame_Shift_Del	DEL	AG	TCGA-CV-6938-01A-11D-1912-08	2251	41277959	156744471	36	36263											
RTP3	83597	broad.mit.edu	37	chr3	46539589	46539589	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgtggaagcaaatgtttCaggagttaatgcgggaggtg	12	10	16	3	1	1	0	1	0	0	0	1	3	1	3	0	4	2	3	0	4	4	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr3:46539589C>A	uc003cps.1	+	1	105	c.37C>A	c.(37-39)CAG>AAG	p.Q13K		NM_031440	NP_113628	Q9BQQ7	RTP3_HUMAN	transmembrane protein 7	13	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		GCAAATGTTTCAGGAGTTAAT	0.587													9	73					5.4927e-09	7.25936e-09	1	0	A	46539589	A	A	46539589	3	1	197	1	0	0	0	0	1	0	0	0	13800	827	29	2	39	2	RTP3	3	46539589	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	5261630	46539589	151482841	37	36264											
USP19	10869	broad.mit.edu	37	chr3	49152891	49152891	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaccatggaagaagtccCggagttcccgagtgttggac	9	8	12	12	2	1	1	1	0	0	1	3	5	3	4	4	3	0	2	4	3	2	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr3:49152891C>T	uc003cwd.1	-	11	1726	c.1565G>A	c.(1564-1566)CGG>CAG	p.R522Q	USP19_uc003cwa.2_Missense_Mutation_p.R330Q|USP19_uc003cvz.3_Missense_Mutation_p.R625Q|USP19_uc011bcg.1_Missense_Mutation_p.R613Q|USP19_uc003cwb.2_Missense_Mutation_p.R608Q|USP19_uc003cwc.1_Missense_Mutation_p.R280Q|USP19_uc011bch.1_Missense_Mutation_p.R623Q|USP19_uc011bci.1_Missense_Mutation_p.R610Q	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	522	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GAAGAAGTCCCGGAGTTCCCG	0.527													13	73					0	0	0	0	T	49152891	T	T	49152891	3	4	197	1	0	0	0	0	1	0	0	0	17118	652	23	1	2455	1	USP19	3	49152891	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	2613302	49152891	148869539	38	36265											
CD80	941	broad.mit.edu	37	chr3	119263487	119263487	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactcgtatgtgccctcgtCagatgggcgcagagccagga	9	7	13	12	3	1	2	1	0	0	2	3	3	1	3	2	2	2	2	2	2	1	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr3:119263487C>A	uc003ecq.2	-	3	723	c.328G>T	c.(328-330)GAC>TAC	p.D110Y	CD80_uc010hqt.1_Missense_Mutation_p.D110Y|CD80_uc010hqu.1_Missense_Mutation_p.D110Y|CD80_uc003ecr.1_Missense_Mutation_p.D110Y	NM_005191	NP_005182	P33681	CD80_HUMAN	CD80 antigen precursor	110	Extracellular (Potential).|Ig-like V-type.				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2					Abatacept(DB01281)	GTGCCCTCGTCAGATGGGCGC	0.483													10	86					0.000673444	0.00085027	1	0	A	119263487	A	A	119263487	3	1	197	1	0	0	0	0	1	0	0	0	3053	826	29	2	554	2	CD80	3	119263487	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	70110596	119263487	78758943	39	36266											
POLQ	10721	broad.mit.edu	37	chr3	121208599	121208599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatggattctacacgctccaGagtctttcagggggctgctg	8	11	12	10	1	3	1	1	0	2	1	4	2	4	2	1	3	2	3	1	3	2	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr3:121208599G>A	uc003eee.3	-	16	3308	c.3179C>T	c.(3178-3180)TCT>TTT	p.S1060F	POLQ_uc003eed.2_Missense_Mutation_p.S232F	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1060					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		ACACGCTCCAGAGTCTTTCAG	0.408								DNA_polymerases_(catalytic_subunits)					10	128					0	0	0	0	A	121208599	A	A	121208599	3	1	197	1	0	0	0	0	1	0	0	0	12263	942	33	2	4653	2	POLQ	3	121208599	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1945112	121208599	76813831	40	36267											
SEMA5B	54437	broad.mit.edu	37	chr3	122642482	122642482	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acctggaaattggggatgggGttggctatggggagccaggc	8	8	19	6	0	0	0	0	0	0	0	0	3	0	3	2	9	1	2	2	9	2	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr3:122642482G>A	uc003efz.1	-	10	1558	c.1254C>T	c.(1252-1254)AAC>AAT	p.N418N	SEMA5B_uc011bju.1_Silent_p.N360N|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.N418N|SEMA5B_uc010hro.1_Silent_p.N360N|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	418	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGGGGATGGGGTTGGCTATGG	0.557													13	96					0	0	0	0	A	122642482	A	A	122642482	2	1	197	1	0	0	0	0	0	0	0	1	14103	1252	44	4		4	SEMA5B	3	122642482	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1433883	122642482	75379948	41	36268											
EPHB1	2047	broad.mit.edu	37	chr3	134670357	134670357	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcgcatctacacagagatgCgcttcactgtgagagactgc	11	9	10	11	2	2	3	1	1	1	2	3	5	2	3	0	0	3	2	0	0	1	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr3:134670357C>T	uc003eqt.2	+	3	488	c.268C>T	c.(268-270)CGC>TGC	p.R90C	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Missense_Mutation_p.R90C	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	90	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CACAGAGATGCGCTTCACTGT	0.537													4	42					0	0	0	0	T	134670357	T	T	134670357	3	4	197	1	0	0	0	0	1	0	0	0	5198	768	27	1	278	1	EPHB1	3	134670357	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	12027875	134670357	63352073	42	36269											
HTRA3	94031	broad.mit.edu	37	chr4	8305956	8305956	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacccggacttcccagaggtCagcagtggaatttatgtgca	11	9	11	10	1	1	1	1	0	0	1	2	3	2	3	2	3	3	2	2	3	3	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr4:8305956C>G	uc003gla.2	+	8	1350	c.1146C>G	c.(1144-1146)GTC>GTG	p.V382V		NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	382	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						TCCCAGAGGTCAGCAGTGGAA	0.597													9	68					0	0	0	0	G	8305956	G	G	8305956	2	3	197	1	0	0	0	0	0	0	0	1	7494	813	29	2		2	HTRA3	4	8305956	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08		8305956	182848320	43	36270											
UGT2B4	7363	broad.mit.edu	37	chr4	70352332	70352332	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttcagagacttaccaagaAgatcattctggggtatccac	12	11	8	10	0	4	3	2	0	2	3	5	4	5	3	2	2	1	1	2	2	4	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr4:70352332A>G	uc003hek.3	-	4	1132	c.1085T>C	c.(1084-1086)CTT>CCT	p.L362P	UGT2B4_uc011cap.1_Missense_Mutation_p.L226P|UGT2B4_uc003hel.3_Missense_Mutation_p.L362P	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	362					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CTTACCAAGAAGATCATTCTG	0.338													10	78					0	0	0	0	G	70352332	G	G	70352332	3	3	197	1	0	0	0	0	1	0	0	0	17029	72	3	5	513	5	UGT2B4	4	70352332	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	62046376	70352332	120801944	44	36271											
ENAM	10117	broad.mit.edu	37	chr4	71510266	71510266	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtcaagtccaagaaaatgaGagtgagaggcaacagcaaag	19	4	12	6	0	1	3	1	2	0	3	2	5	2	3	1	1	2	2	1	1	6	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr4:71510266G>A	uc011caw.1	+	9	3404	c.3123G>A	c.(3121-3123)GAG>GAA	p.E1041E		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	1041					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AAGAAAATGAGAGTGAGAGGC	0.448													7	57					0	0	0	0	A	71510266	A	A	71510266	2	1	197	1	0	0	0	0	0	0	0	1	5136	933	33	2		2	ENAM	4	71510266	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1157934	71510266	119644010	45	36272											
USO1	8615	broad.mit.edu	37	chr4	76721831	76721831	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagaatttcatagagaaactAggatttattagcaaacatga	18	11	8	4	0	1	3	1	1	0	2	1	6	1	4	0	1	3	1	0	1	7	6			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr4:76721831A>C	uc003hiu.2	+	15	1918	c.1743A>C	c.(1741-1743)CTA>CTC	p.L581L	USO1_uc003hiv.2_Silent_p.L423L|USO1_uc003hiw.2_Silent_p.L416L	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	581	Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TAGAGAAACTAGGATTTATTA	0.353													9	77					0	0	0	0	C	76721831	C	C	76721831	2	2	197	1	0	0	0	0	0	0	0	1	17107	407	15	5		5	USO1	4	76721831	Silent	SNP	A	TCGA-CV-6938-01A-11D-1912-08	5211565	76721831	114432445	46	36273											
FAT1	2195	broad.mit.edu	37	chr4	187524190	187524190	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaggtgggcaccttccctcTtcattcaaagaggggagaaa	12	8	11	10	0	3	2	2	0	1	2	4	3	4	2	2	4	0	1	2	4	2	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr4:187524190T>C	uc003izf.2	-	20	11539	c.11351_splice	c.e20-1	p.E3784_splice		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACCTTCCCTCTTCATTCAAAG	0.483										HNSCC(5;0.00058)			21	70					0	0	0	0	C	187524190	C	C	187524190	5	2	197	1	0	0	0	0	0	0	1	0	5721	1623	56	5	2449	5	FAT1	4	187524190	Splice_Site	SNP	T	TCGA-CV-6938-01A-11D-1912-08	110802359	187524190	3630086	47	36274											
CDH10	1008	broad.mit.edu	37	chr5	24537731	24537731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaagagtaccagctccatctCcagataagatatatttgagt	15	11	7	8	0	1	4	0	1	1	3	3	4	2	4	3	0	2	2	3	0	5	5			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:24537731C>T	uc003jgr.1	-	3	616	c.284G>A	c.(283-285)GGA>GAA	p.G95E	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	95	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AGCTCCATCTCCAGATAAGAT	0.368										HNSCC(23;0.051)			6	57					0	0	0	0	T	24537731	T	T	24537731	3	4	197	1	0	0	0	0	1	0	0	0	3111	855	30	2	2122	2	CDH10	5	24537731	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		24537731	156377529	48	36275											
FCHO2	115548	broad.mit.edu	37	chr5	72285313	72285313	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actagcaaaatctgcaagcaAttattcacaacttgggtgag	15	10	8	8	0	2	1	1	1	1	0	2	1	2	1	0	1	4	3	0	1	7	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:72285313A>G	uc003kcl.2	+	3	301	c.185A>G	c.(184-186)AAT>AGT	p.N62S	FCHO2_uc011csl.1_Missense_Mutation_p.N62S|FCHO2_uc011csk.1_Missense_Mutation_p.N62S|FCHO2_uc011csm.1_5'Flank	NM_138782	NP_620137	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2 isoform a	62	FCH.									ovary(1)	1		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		TCTGCAAGCAATTATTCACAA	0.348													3	11					0	0	0	0	G	72285313	G	G	72285313	3	3	197	1	0	0	0	0	1	0	0	0	5820	101	4	5	195	5	FCHO2	5	72285313	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	47747582	72285313	108629947	49	36276											
VCAN	1462	broad.mit.edu	37	chr5	82817330	82817330	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactggatgaacaagagggcGatggatcagcatatacagtc	14	7	12	8	1	1	2	1	1	0	1	2	5	1	4	0	3	3	1	0	3	4	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:82817330G>A	uc003kii.3	+	7	3561	c.3205G>A	c.(3205-3207)GAT>AAT	p.D1069N	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.D1069N|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1069	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACAAGAGGGCGATGGATCAGC	0.463													10	53					0	0	0	0	A	82817330	A	A	82817330	3	1	197	1	0	0	0	0	1	0	0	0	17206	1058	37	1	3227	1	VCAN	5	82817330	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	10532017	82817330	98097930	50	36277											
GPR98	84059	broad.mit.edu	37	chr5	90074703	90074703	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaacatcacaatcatccgtTccagtggagattttggccat	11	13	7	10	1	2	1	2	0	0	1	4	2	4	1	3	2	1	1	3	2	2	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:90074703T>C	uc003kju.2	+	64	12967	c.12871T>C	c.(12871-12873)TCC>CCC	p.S4291P	GPR98_uc003kjt.2_Missense_Mutation_p.S1997P|GPR98_uc003kjw.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4291	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AATCATCCGTTCCAGTGGAGA	0.433													16	150					0	0	0	0	C	90074703	C	C	90074703	3	2	197	1	0	0	0	0	1	0	0	0	6760	1783	62	5	13125	5	GPR98	5	90074703	Missense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08	7257373	90074703	90840557	51	36278											
AP3S1	1176	broad.mit.edu	37	chr5	115205749	115205749	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacaacaaactgatttataGacattatgcaacgttatatt	16	14	5	6	1	0	3	0	2	0	1	0	3	0	3	0	0	4	2	0	0	8	7			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:115205749G>C	uc003krl.2	+	3	313	c.197G>C	c.(196-198)AGA>ACA	p.R66T	AP3S1_uc003krk.2_Missense_Mutation_p.R44T|AP3S1_uc003krm.2_Missense_Mutation_p.R66T	NM_001284	NP_001275	Q92572	AP3S1_HUMAN	adaptor-related protein complex 3, sigma 1	66					insulin receptor signaling pathway|intracellular protein transport|vesicle-mediated transport	AP-type membrane coat adaptor complex|cytoplasmic vesicle membrane|Golgi apparatus|transport vesicle	protein binding|protein transporter activity				0		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;1.08e-07)|Epithelial(69;1.11e-06)|all cancers(49;5.2e-05)		CTGATTTATAGACATTATGCA	0.303													3	81					0	0	0	0	C	115205749	C	C	115205749	3	2	197	1	0	0	0	0	1	0	0	0	749	942	33	2	207	2	AP3S1	5	115205749	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	25131046	115205749	65709511	52	36279											
IL3	3562	broad.mit.edu	37	chr5	131396411	131396411	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccaaacatgagccgcctGcccgtcctgctcctgctcca	7	8	8	18	2	0	1	0	1	0	0	4	2	4	1	7	0	5	2	7	0	1	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:131396411G>T	uc003kwe.1	+	1	65	c.12G>T	c.(10-12)CTG>CTT	p.L4L		NM_000588	NP_000579	P08700	IL3_HUMAN	interleukin 3 precursor	4					cell-cell signaling|immune response|nervous system development|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of survival gene product expression|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|growth factor activity|interleukin-3 receptor binding			ovary(2)|central_nervous_system(1)	3		all_cancers(142;7.42e-12)|Lung NSC(810;4.25e-07)|all_lung(232;1.93e-06)|Prostate(281;0.00741)|Breast(839;0.0544)|Lung SC(612;0.122)|Ovarian(839;0.223)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.0161)|Lung(113;0.105)	Amlexanox(DB01025)	TGAGCCGCCTGCCCGTCCTGC	0.587													4	56					0.00024832	0.000315283	1	0	T	131396411	T	T	131396411	2	4	197	1	0	0	0	0	0	0	0	1	7728	1306	46	4		4	IL3	5	131396411	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08	16190662	131396411	49518849	53	36280											
PCDHA9	9752	broad.mit.edu	37	chr5	140229894	140229894	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccgactcgggctacaacgCgtggctttcatacgagctgc	7	8	12	14	6	1	0	1	0	0	0	2	2	1	0	1	2	5	3	1	2	3	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:140229894C>T	uc003lhu.2	+	1	2538	c.1814C>T	c.(1813-1815)GCG>GTG	p.A605V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.A605V	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	605	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTACAACGCGTGGCTTTCA	0.682													9	91					0	0	0	0	T	140229894	T	T	140229894	3	4	197	1	0	0	0	0	1	0	0	0	11585	768	27	1	1816	1	PCDHA9	5	140229894	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	8833483	140229894	40685366	54	36281											
PCDHA11	56138	broad.mit.edu	37	chr5	140250227	140250227	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgtcggtgcacgcggagagCggcaaggtgtacgcgctgca	7	6	18	10	6	0	1	0	0	0	1	1	2	0	1	0	4	4	5	0	4	2	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:140250227C>T	uc003lia.2	+	1	2397	c.1539C>T	c.(1537-1539)AGC>AGT	p.S513S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.S513S	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	513	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCGGAGAGCGGCAAGGTGT	0.697													26	180					0	0	0	0	T	140250227	T	T	140250227	2	4	197	1	0	0	0	0	0	0	0	1	11575	767	27	1		1	PCDHA11	5	140250227	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	20333	140250227	40665033	55	36282											
PDGFRB	5159	broad.mit.edu	37	chr5	149501528	149501528	+	Frame_Shift_Del	DEL	G	-	-																															tctcctttcatgtccagcatGggcacatagtccaccgactc																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:149501528delG	uc003lro.2	-	16	2728	c.2259delC	c.(2257-2259)CCCfs	p.P753fs	PDGFRB_uc010jhd.2_Frame_Shift_Del_p.P592fs	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	753	Cytoplasmic (Potential).|Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TGTCCAGCATGGGCACATAGT	0.542			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								---	---	---								-	149501528	-	-	149501528	7	5	197	1	0	1	0	1	0	0	0	0	11716	1335	47	0	1093	0	PDGFRB	5	149501528	Frame_Shift_Del	DEL	G	TCGA-CV-6938-01A-11D-1912-08	9251301	149501528	31413732	56	36283											
HAVCR1	26762	broad.mit.edu	37	chr5	156479608	156479608	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgttggaacagtggtgctcGttcgaacagtcgtgacggtt	7	12	14	8	5	0	1	0	1	0	0	4	3	0	2	0	3	3	4	0	3	2	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:156479608G>C	uc010jij.1	-	4	622	c.437C>G	c.(436-438)ACG>AGG	p.T146R	HAVCR1_uc011ddl.1_5'UTR|HAVCR1_uc003lwi.2_Missense_Mutation_p.T146R|HAVCR1_uc011ddm.1_Missense_Mutation_p.T146R	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	146	Extracellular (Potential).|11 X 6 AA approximate tandem repeats of V-P-T-T-T-T].|Thr-rich.|2.				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTGGTGCTCGTTCGAACAGT	0.468													60	469					0	0	0	0	C	156479608	C	C	156479608	3	2	197	1	0	0	0	0	1	0	0	0	7012	1145	40	3	681	3	HAVCR1	5	156479608	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	6978080	156479608	24435652	57	36284											
EBF1	1879	broad.mit.edu	37	chr5	158522653	158522653	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcatggagtcaatgaggCgcacgtagaaatcctgctcc	10	10	11	10	2	2	2	2	1	0	1	4	3	4	3	2	2	1	3	2	2	3	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:158522653C>T	uc010jip.2	-	4	688	c.386G>A	c.(385-387)CGC>CAC	p.R129H	EBF1_uc011ddw.1_5'UTR|EBF1_uc011ddx.1_Missense_Mutation_p.R129H|EBF1_uc003lxl.3_Missense_Mutation_p.R129H	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	129					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCAATGAGGCGCACGTAGAA	0.483			T	HMGA2	lipoma								15	72					0	0	0	0	T	158522653	T	T	158522653	3	4	197	1	0	0	0	0	1	0	0	0	4902	768	27	1	1441	1	EBF1	5	158522653	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	2043045	158522653	22392607	58	36285											
ODZ2	57451	broad.mit.edu	37	chr5	167643922	167643922	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgattccagcatggatgtaGcccaggtgagactctttctt	8	13	11	9	0	2	2	0	2	2	1	3	4	3	3	2	2	2	2	2	2	1	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr5:167643922G>A	uc010jjd.2	+	22	4201	c.4201G>A	c.(4201-4203)GCC>ACC	p.A1401T	ODZ2_uc003lzr.3_Missense_Mutation_p.A1171T|ODZ2_uc003lzt.3_Missense_Mutation_p.A774T|ODZ2_uc010jje.2_Missense_Mutation_p.A665T	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CATGGATGTAGCCCAGGTGAG	0.527													10	103					0	0	0	0	A	167643922	A	A	167643922	3	1	197	1	0	0	0	0	1	0	0	0	10889	971	34	4	4287	4	ODZ2	5	167643922	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	9121269	167643922	13271338	59	36286											
NUP153	9972	broad.mit.edu	37	chr6	17669742	17669742	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaccgtaagattgtgcactGagttgcttagctttcatttg	9	15	9	8	1	1	2	1	1	0	1	1	2	1	2	1	0	3	5	1	0	2	6	rs149307511	by1000genomes	TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr6:17669742G>C	uc003ncd.1	-	6	1088	c.888C>G	c.(886-888)CTC>CTG	p.L296L	NUP153_uc011dje.1_Silent_p.L296L|NUP153_uc010jpl.1_Silent_p.L296L	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	296					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			ATTGTGCACTGAGTTGCTTAG	0.383													5	36					0	0	0	0	C	17669742	C	C	17669742	2	2	197	1	0	0	0	0	0	0	0	1	10809	1277	45	2		2	NUP153	6	17669742	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08		17669742	153445325	60	36287											
HIST1H2AA	221613	broad.mit.edu	37	chr6	25726614	25726614	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccgccaaatacactggtgCgcctgcccctatccgctctg	6	9	9	17	3	1	0	0	0	1	0	2	0	2	0	6	1	4	1	6	1	3	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr6:25726614C>T	uc003nfc.2	-	1	177	c.142G>A	c.(142-144)GCA>ACA	p.A48T	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	48					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TACACTGGTGCGCCTGCCCCT	0.517													4	65					0	0	0	0	T	25726614	T	T	25726614	3	4	197	1	0	0	0	0	1	0	0	0	7167	768	27	1	257	1	HIST1H2AA	6	25726614	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	8056872	25726614	145388453	61	36288											
HIST1H4E	8367	broad.mit.edu	37	chr6	26205053	26205053	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agactcgcggggttctgaagGtgtttctggaaaacgtgatt	9	12	14	6	3	2	3	0	2	2	1	3	4	2	4	0	4	1	2	0	4	3	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr6:26205053G>C	uc003ngy.2	+	1	181	c.181G>C	c.(181-183)GTG>CTG	p.V61L		NM_003545	NP_003536	P62805	H4_HUMAN	histone cluster 1, H4e	61					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				GGTTCTGAAGGTGTTTCTGGA	0.567													9	87					0	0	0	0	C	26205053	C	C	26205053	3	2	197	1	0	0	0	0	1	0	0	0	7208	1261	44	4	183	4	HIST1H4E	6	26205053	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	478439	26205053	144910014	62	36289											
HIST1H1B	3009	broad.mit.edu	37	chr6	27834947	27834947	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcctgccttcttggctttggGcttggcttccccggaggccg	1	12	14	14	2	1	0	0	0	1	0	2	1	2	1	5	5	1	3	5	5	0	5			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr6:27834947G>C	uc003njx.2	-	1	413	c.361C>G	c.(361-363)CCC>GCC	p.P121A		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	121					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						TTGGCTTTGGGCTTGGCTTCC	0.597													27	181					0	0	0	0	C	27834947	C	C	27834947	3	2	197	1	0	0	0	0	1	0	0	0	7162	1203	42	4	323	4	HIST1H1B	6	27834947	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1629894	27834947	143280120	63	36290											
TBCC	6903	broad.mit.edu	37	chr6	42712835	42712836	+	Frame_Shift_Ins	INS	-	G	G																															gtttggggaggccatatcccINSgggccagccagttaaaatcg																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr6:42712835_42712836insG	uc003osl.2	-	1	1049_1050	c.976_977insC	c.(976-978)CGGfs	p.R326fs		NM_003192	NP_003183	Q15814	TBCC_HUMAN	beta-tubulin cofactor C	326					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity				0	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			GGCCATATCCCGGGCCAGCCAG	0.485													---	---	---								G	42712836	G	G	42712835	7	5	197	1	0	1	1	0	0	0	0	0	15697	652	23	0	67	0	TBCC	6	42712835	Frame_Shift_Ins	INS	-	TCGA-CV-6938-01A-11D-1912-08	14877888	42712835	128402232	64	36291											
DST	667	broad.mit.edu	37	chr6	56765371	56765371	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcttccagacgggcagctgCggccgctgcaactcgtcttc	5	10	11	15	4	2	1	0	0	2	1	5	1	3	1	2	2	4	4	2	2	1	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr6:56765371C>T	uc003pdf.2	-	3	293	c.265G>A	c.(265-267)GCA>ACA	p.A89T		NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:Variant_position_missing_in_Q03001_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CGGGCAGCTGCGGCCGCTGCA	0.507													11	71					0	0	0	0	T	56765371	T	T	56765371	3	4	197	1	0	0	0	0	1	0	0	0	4805	783	27	1		1	DST	6	56765371	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	14052536	56765371	114349696	65	36292											
KPNA5	3841	broad.mit.edu	37	chr6	117050816	117050816	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtggctttaaatggactTgaaaatattttacgtcttgg	12	15	9	5	1	1	1	0	1	1	0	1	2	1	2	0	3	1	1	0	3	7	7			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr6:117050816T>C	uc003pxh.2	+	13	1475	c.1344T>C	c.(1342-1344)CTT>CTC	p.L448L		NM_002269	NP_002260	O15131	IMA5_HUMAN	karyopherin alpha 5	445	ARM 9.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		TAAATGGACTTGAAAATATTT	0.363													16	120					0	0	0	0	C	117050816	C	C	117050816	2	2	197	1	0	0	0	0	0	0	0	1	8472	1799	63	5		5	KPNA5	6	117050816	Silent	SNP	T	TCGA-CV-6938-01A-11D-1912-08	60285445	117050816	54064251	66	36293											
HDDC2	51020	broad.mit.edu	37	chr6	125619867	125619867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtcaacactgacctcttctCgcctatgtttttcttctttg	6	18	5	12	1	5	1	1	1	4	0	6	1	5	1	2	0	1	1	2	0	2	6			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr6:125619867C>T	uc003qaa.1	-	3	506	c.302G>A	c.(301-303)CGA>CAA	p.R101Q	HDDC2_uc003qab.1_Intron	NM_016063	NP_057147	Q7Z4H3	HDDC2_HUMAN	HD domain containing 2	101	HD.						metal ion binding|phosphoric diester hydrolase activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0186)		GACCTCTTCTCGCCTATGTTT	0.269													4	43					0	0	0	0	T	125619867	T	T	125619867	3	4	197	1	0	0	0	0	1	0	0	0	7055	884	31	1	328	1	HDDC2	6	125619867	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	8569051	125619867	45495200	67	36294											
SDK1	221935	broad.mit.edu	37	chr7	4014086	4014086	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacgggtcccttctcatcAgccagacgtggtcaggcgac	8	7	13	13	3	3	1	3	0	1	1	5	3	4	2	2	4	1	0	2	4	0	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr7:4014086A>T	uc003smx.2	+	13	2042	c.1903A>T	c.(1903-1905)AGC>TGC	p.S635C		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	635	Ig-like C2-type 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCTTCTCATCAGCCAGACGTG	0.562													11	49					0	0	0	0	T	4014086	T	T	4014086	3	4	197	1	0	0	0	0	1	0	0	0	14033	188	7	5	1953	5	SDK1	7	4014086	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08		4014086	155124577	68	36295											
NEUROD6	63974	broad.mit.edu	37	chr7	31377952	31377952	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtcgtaagggaagtggctgtCggtgggcaacctgaacatgg	9	8	17	7	2	0	1	0	1	0	0	2	2	0	2	1	5	2	3	1	5	4	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr7:31377952C>G	uc003tch.2	-	2	1284	c.931G>C	c.(931-933)GAC>CAC	p.D311H		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	311					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						AAGTGGCTGTCGGTGGGCAAC	0.448													8	71					0	0	0	0	G	31377952	G	G	31377952	3	3	197	1	0	0	0	0	1	0	0	0	10405	884	31	3	86	3	NEUROD6	7	31377952	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	27363866	31377952	127760711	69	36296											
ASB4	51666	broad.mit.edu	37	chr7	95157420	95157420	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cccctccacaaggcagcctgGaactgtgaccacgtgctcat	9	7	9	16	1	1	1	1	1	0	0	2	2	2	2	5	2	3	2	5	2	2	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr7:95157420G>C	uc011kij.1	+	3	783	c.783G>C	c.(781-783)TGG>TGC	p.W261C	ASB4_uc003unx.2_Missense_Mutation_p.W261C	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	261	ANK 6.				intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			AGGCAGCCTGGAACTGTGACC	0.562											OREG0018172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	66					0	0	0	0	C	95157420	C	C	95157420	3	2	197	1	0	0	0	0	1	0	0	0	1027	1183	41	2	793	2	ASB4	7	95157420	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	63779468	95157420	63981243	70	36297											
PIK3CG	5294	broad.mit.edu	37	chr7	106509928	106509928	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctcagatgaaaatgtaaGagccattgcagttcagaaac	15	10	8	8	0	2	4	2	1	1	3	3	4	2	4	1	0	3	3	1	0	4	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr7:106509928G>C	uc003vdv.3	+	2	2007	c.1922G>C	c.(1921-1923)AGA>ACA	p.R641T	PIK3CG_uc003vdu.2_Missense_Mutation_p.R641T|PIK3CG_uc003vdw.2_Missense_Mutation_p.R641T	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	641					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GAAAATGTAAGAGCCATTGCA	0.338													5	67					0	0	0	0	C	106509928	C	C	106509928	3	2	197	1	0	0	0	0	1	0	0	0	11971	942	33	2	1924	2	PIK3CG	7	106509928	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	11352508	106509928	52628735	71	36298											
CNOT4	4850	broad.mit.edu	37	chr7	135047645	135047645	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcctctttgcctaatggcGgtccagtgttgaactctgta	6	14	10	11	1	2	1	0	1	2	0	4	1	4	1	3	2	2	3	3	2	3	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr7:135047645G>A	uc011kpy.1	-	11	2226	c.2134C>T	c.(2134-2136)CGC>TGC	p.R712C	CNOT4_uc003vss.2_Missense_Mutation_p.R638C|CNOT4_uc011kpz.1_Missense_Mutation_p.R709C|CNOT4_uc003vst.2_Missense_Mutation_p.R641C	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	Error:Variant_position_missing_in_O95628_after_alignment					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						GCCTAATGGCGGTCCAGTGTT	0.527													45	399					0	0	0	0	A	135047645	A	A	135047645	3	1	197	1	0	0	0	0	1	0	0	0	3636	1116	39	1	11	1	CNOT4	7	135047645	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	28537717	135047645	24091018	72	36299											
EPHA1	2041	broad.mit.edu	37	chr7	143088618	143088618	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcagtgtgattcccatctGcgtcaggtccctgtgggcaa	6	10	14	11	1	2	1	1	1	1	0	4	1	4	1	2	3	1	2	2	3	1	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr7:143088618G>A	uc003wcz.2	-	18	2950	c.2863C>T	c.(2863-2865)CAG>TAG	p.Q955*		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	955	SAM.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				ATTCCCATCTGCGTCAGGTCC	0.622													6	33					0	0	0	0	A	143088618	A	A	143088618	4	1	197	1	0	0	0	0	0	1	0	0	5189	1328	46	4	71	4	EPHA1	7	143088618	Nonsense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	8040973	143088618	16050045	73	36300											
DPP6	1804	broad.mit.edu	37	chr7	154561208	154561208	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccgccatcaatgattcccGtgtccccatcatggagctcc	7	9	8	17	3	2	1	2	1	0	0	5	2	5	2	6	1	1	1	6	1	1	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr7:154561208G>A	uc003wlk.2	+	9	1094	c.965G>A	c.(964-966)CGT>CAT	p.R322H	DPP6_uc003wli.2_Missense_Mutation_p.R258H|DPP6_uc003wlm.2_Missense_Mutation_p.R260H|DPP6_uc011kvq.1_Missense_Mutation_p.R215H	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	322	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AATGATTCCCGTGTCCCCATC	0.552													7	52					0	0	0	0	A	154561208	A	A	154561208	3	1	197	1	0	0	0	0	1	0	0	0	4752	1145	40	1	1115	1	DPP6	7	154561208	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	11472590	154561208	4577455	74	36301											
ADAM7	8756	broad.mit.edu	37	chr8	24333985	24333985	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacaataaactaaggaacCgaatttggggaatggtcaat	16	9	9	7	1	2	0	2	0	0	0	2	3	2	2	1	4	2	0	1	4	8	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr8:24333985C>T	uc003xeb.2	+	8	786	c.673C>T	c.(673-675)CGA>TGA	p.R225*	ADAM7_uc003xec.2_5'UTR	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	225	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		ACTAAGGAACCGAATTTGGGG	0.318													5	43					0	0	0	0	T	24333985	T	T	24333985	4	4	197	1	0	0	0	0	0	1	0	0	251	644	23	1	703	1	ADAM7	8	24333985	Nonsense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		24333985	122030037	75	36302											
NEFL	4747	broad.mit.edu	37	chr8	24811239	24811239	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaaagacctgggagctctGggagtagccactggttatgc	9	8	14	10	0	1	1	0	0	1	1	1	3	1	3	3	3	3	3	3	3	3	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr8:24811239G>T	uc003xee.2	-	3	1342	c.1240C>A	c.(1240-1242)CAG>AAG	p.Q414K		NM_006158	NP_006149	P07196	NFL_HUMAN	neurofilament, light polypeptide 68kDa	414	Tail.|Tail, subdomain A.				anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		TGGGAGCTCTGGGAGTAGCCA	0.562													12	80					1.61879e-10	2.17766e-10	1	0	T	24811239	T	T	24811239	3	4	197	1	0	0	0	0	1	0	0	0	10369	1357	47	4	400	4	NEFL	8	24811239	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	477254	24811239	121552783	76	36303											
POTEA	340441	broad.mit.edu	37	chr8	43152233	43152233	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctgctggacagacaatgtCaacttcatgtctttgacagc	10	13	8	10	0	4	2	2	1	2	1	4	3	4	3	0	1	3	1	0	1	2	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr8:43152233C>G	uc003xpz.1	+	2	413	c.370C>G	c.(370-372)CAA>GAA	p.Q124E	POTEA_uc003xqa.1_Missense_Mutation_p.Q124E	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	124	ANK 1.									ovary(1)	1						CAGACAATGTCAACTTCATGT	0.388													5	111					0	0	0	0	G	43152233	G	G	43152233	3	3	197	1	0	0	0	0	1	0	0	0	12316	827	29	2	376	2	POTEA	8	43152233	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	18340994	43152233	103211789	77	36304											
PRKDC	5591	broad.mit.edu	37	chr8	48733339	48733339	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctctgtcaacatcatcttGcaggaggtaaagcagactca	12	9	10	10	0	5	1	3	0	2	1	5	2	5	2	0	3	3	4	0	3	3	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr8:48733339G>A	uc003xqi.2	-	67	9334	c.9277C>T	c.(9277-9279)CAA>TAA	p.Q3093*	PRKDC_uc003xqj.2_Nonsense_Mutation_p.Q3093*|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3093	KIP-binding.|FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACATCATCTTGCAGGAGGTAA	0.358								NHEJ					7	21					0	0	0	0	A	48733339	A	A	48733339	4	1	197	1	0	0	0	0	0	1	0	0	12583	1328	46	4	3193	4	PRKDC	8	48733339	Nonsense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	5581106	48733339	97630683	78	36305											
TRPA1	8989	broad.mit.edu	37	chr8	72951161	72951161	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgccagttgagttgaaaGccattcctggttttatattg	9	16	10	6	0	0	3	0	3	0	0	1	3	1	3	3	1	2	3	3	1	3	7			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr8:72951161G>T	uc003xza.2	-	19	2409	c.2234C>A	c.(2233-2235)GCT>GAT	p.A745D	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	745	Extracellular (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TGAGTTGAAAGCCATTCCTGG	0.328													10	73					2.74318e-10	3.66839e-10	1	0	T	72951161	T	T	72951161	3	4	197	1	0	0	0	0	1	0	0	0	16644	971	34	4	1161	4	TRPA1	8	72951161	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	24217822	72951161	73412861	79	36306											
PLEC	5339	broad.mit.edu	37	chr8	145003892	145003892	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcagccatcagccggtcctCgggtccgaagccgcccgcgt	5	6	12	18	6	2	0	2	0	0	0	5	1	4	0	6	2	3	0	6	2	1	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr8:145003892C>T	uc003zaf.1	-	23	3426	c.3256G>A	c.(3256-3258)GAG>AAG	p.E1086K	PLEC_uc003zab.1_Missense_Mutation_p.E949K|PLEC_uc003zac.1_Missense_Mutation_p.E953K|PLEC_uc003zad.2_Missense_Mutation_p.E949K|PLEC_uc003zae.1_Missense_Mutation_p.E917K|PLEC_uc003zag.1_Missense_Mutation_p.E927K|PLEC_uc003zah.2_Missense_Mutation_p.E935K|PLEC_uc003zaj.2_Missense_Mutation_p.E976K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1086	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGCCGGTCCTCGGGTCCGAAG	0.692													10	21					0	0	0	0	T	145003892	T	T	145003892	3	4	197	1	0	0	0	0	1	0	0	0	12107	893	31	1	10838	1	PLEC	8	145003892	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	72052731	145003892	1360130	80	36307											
SPTAN1	6709	broad.mit.edu	37	chr9	131348167	131348167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtactttgctgatgctaacGaggctgaatcctggatgcgg	9	11	13	8	2	0	2	0	2	0	0	1	4	1	3	1	3	5	4	1	3	3	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr9:131348167G>A	uc004bvl.3	+	19	2814	c.2701G>A	c.(2701-2703)GAG>AAG	p.E901K	SPTAN1_uc011mbg.1_Missense_Mutation_p.E901K|SPTAN1_uc011mbh.1_Missense_Mutation_p.E913K|SPTAN1_uc004bvm.3_Missense_Mutation_p.E901K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E901K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	901	Spectrin 10.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGATGCTAACGAGGCTGAATC	0.572													10	79					0	0	0	0	A	131348167	A	A	131348167	3	1	197	1	0	0	0	0	1	0	0	0	15183	1059	37	1	2771	1	SPTAN1	9	131348167	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08		131348167	9865264	81	36308											
PPAPDC3	84814	broad.mit.edu	37	chr9	134165490	134165490	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaggggggcccggagcccCgcagctcgggcagaaaggcc	8	1	17	15	3	0	1	0	0	0	1	1	2	0	2	5	6	2	3	5	6	2	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr9:134165490C>T	uc004cal.2	+	1	410	c.106C>T	c.(106-108)CGC>TGC	p.R36C		NM_032728	NP_116117	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain	36	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(1)	1	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)		CCCGGAGCCCCGCAGCTCGGG	0.706													9	23					0	0	0	0	T	134165490	T	T	134165490	3	4	197	1	0	0	0	0	1	0	0	0	12351	652	23	1	108	1	PPAPDC3	9	134165490	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	2817323	134165490	7047941	82	36309											
NOTCH1	4851	broad.mit.edu	37	chr9	139402475	139402475	+	Frame_Shift_Del	DEL	C	-	-																															gcaggggctgggtgagcactCgtccaccaggtcctcacagt																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr9:139402475delC	uc004chz.2	-	21	3442	c.3442delG	c.(3442-3444)GAGfs	p.E1148fs	NOTCH1_uc004cia.1_Frame_Shift_Del_p.E378fs	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1148	Extracellular (Potential).|EGF-like 30.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGTGAGCACTCGTCCACCAGG	0.672			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								-	139402475	-	-	139402475	7	5	197	1	0	1	0	1	0	0	0	0	10601	893	31	0	4281	0	NOTCH1	9	139402475	Frame_Shift_Del	DEL	C	TCGA-CV-6938-01A-11D-1912-08	5236985	139402475	1810956	83	36310											
KIAA1984	84960	broad.mit.edu	37	chr9	139694847	139694847	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggtccgccccagatcatcCgccagctggagaacaacatc	10	6	9	16	3	1	2	1	0	0	2	5	3	3	2	5	2	3	1	5	2	2	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr9:139694847C>T	uc004cjf.2	+	5	493	c.445C>T	c.(445-447)CGC>TGC	p.R149C		NM_001039374	NP_001034463	Q5T5S1	K1984_HUMAN	hypothetical protein LOC84960	149	Potential.									ovary(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.33e-06)|Epithelial(140;0.000124)		CCAGATCATCCGCCAGCTGGA	0.592													3	17					0	0	0	0	T	139694847	T	T	139694847	3	4	197	1	0	0	0	0	1	0	0	0	8305	652	23	1	463	1	KIAA1984	9	139694847	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	292372	139694847	1518584	84	36311											
LCNL1	401562	broad.mit.edu	37	chr9	139878139	139878139	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttggggaatggtgacctggCcctcaagtttggatacccca	8	10	12	11	0	1	1	1	1	0	0	1	3	1	3	4	5	1	1	4	5	3	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr9:139878139C>T	uc004ckh.1	+	1	695	c.101C>T	c.(100-102)GCC>GTC	p.A34V		NM_207510	NP_997393	Q6ZST4	LCNL1_HUMAN	lipocalin-like 1	34							binding				0						GGTGACCTGGCCCTCAAGTTT	0.572													10	108					0	0	0	0	T	139878139	T	T	139878139	3	4	197	1	0	0	0	0	1	0	0	0	8728	739	26	4	103	4	LCNL1	9	139878139	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	183292	139878139	1335292	85	36312											
BMI1	648	broad.mit.edu	37	chr10	22606902	22606902	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tactagaggcaggaaagcacCgagctgacaagtcaactcta	15	6	10	10	1	2	2	1	1	1	1	2	4	2	3	1	2	4	3	1	2	6	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr10:22606902C>T	uc009xkg.2	+	2	277	c.229C>T	c.(229-231)CGA>TGA	p.R77*	COMMD3_uc001ire.2_Nonsense_Mutation_p.R77*|COMMD3_uc001irf.2_Nonsense_Mutation_p.R77*|COMMD3_uc001irg.2_RNA	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene	Error:Variant_position_missing_in_P35226_after_alignment					hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						AGGAAAGCACCGAGCTGACAA	0.338													7	65					0	0	0	0	T	22606902	T	T	22606902	4	4	197	1	0	0	0	0	0	1	0	0	1458	644	23	1		1	BMI1	10	22606902	Nonsense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		22606902	112927845	86	36313											
HK1	3098	broad.mit.edu	37	chr10	71142523	71142523	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaagatgctgccctccttcGtccggagaactcccgacggg	7	9	11	14	4	0	2	0	0	0	2	4	4	3	2	4	2	3	1	4	2	2	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr10:71142523G>A	uc001jpl.3	+	10	1647	c.1546G>A	c.(1546-1548)GTC>ATC	p.V516I	HK1_uc001jpg.3_Missense_Mutation_p.V504I|HK1_uc001jph.3_Missense_Mutation_p.V520I|HK1_uc001jpi.3_Missense_Mutation_p.V520I|HK1_uc001jpj.3_Missense_Mutation_p.V551I|HK1_uc001jpk.3_Missense_Mutation_p.V515I|HK1_uc009xqd.2_Missense_Mutation_p.V394I	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	516	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						GCCCTCCTTCGTCCGGAGAAC	0.632													9	47					0	0	0	0	A	71142523	A	A	71142523	3	1	197	1	0	0	0	0	1	0	0	0	7229	1145	40	1	1762	1	HK1	10	71142523	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	48535621	71142523	64392224	87	36314											
ADAMTS14	140766	broad.mit.edu	37	chr10	72489916	72489916	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctggagcaggtgtgtcgctGggcacactcccagcagcgcc	6	6	14	15	2	0	0	0	0	0	0	2	1	1	1	3	3	3	4	3	3	0	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr10:72489916G>A	uc001jrh.2	+	6	1013	c.1013G>A	c.(1012-1014)TGG>TAG	p.W338*	ADAMTS14_uc001jrg.2_Nonsense_Mutation_p.W338*	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	338	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						GTGTGTCGCTGGGCACACTCC	0.662													10	74					0	0	0	0	A	72489916	A	A	72489916	4	1	197	1	0	0	0	0	0	1	0	0	259	1357	47	4	1035	4	ADAMTS14	10	72489916	Nonsense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1347393	72489916	63044831	88	36315											
NOC3L	64318	broad.mit.edu	37	chr10	96117971	96117972	+	Frame_Shift_Ins	INS	-	T	T																															cttccctctcaatccttttaINScctgtaccacacacacacac																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr10:96117971_96117972insT	uc001kjq.1	-	3	306_307	c.218_219insA	c.(217-219)GGTfs	p.G73fs	NOC3L_uc009xuk.1_5'UTR	NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	73						nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				CAATCCTTTTACCTGTACCACA	0.376													---	---	---								T	96117972	T	T	96117971	7	5	197	1	0	1	1	0	0	0	0	0	10568	405	14	0	2259	0	NOC3L	10	96117971	Frame_Shift_Ins	INS	-	TCGA-CV-6938-01A-11D-1912-08	23628055	96117971	39416776	89	36316											
LBX1	10660	broad.mit.edu	37	chr10	102988336	102988336	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagcggcgaggtctgcgaGagcagcgcgcggcccgccag	7	2	17	15	7	1	1	0	0	1	1	1	3	1	1	2	3	4	1	2	3	0	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	02eb342c-7609-47ec-a51f-eee833d572ce	g.chr10:102988336G>C	uc001ksx.2	-	1	382	c.237C>G	c.(235-237)CTC>CTG	p.L79L	uc010qpy.1_5'Flank	NM_006562	NP_006553	P52954	LBX1_HUMAN	ladybird homeobox 1	79					muscle organ development		sequence-specific DNA binding				0		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)		AGGTCTGCGAGAGCAGCGCGC	0.711													2	6					0	0	0	0	C	102988336	C	C	102988336	2	2	197	1	0	0	0	0	0	0	0	1	8693	929	33	2		2	LBX1	10	102988336	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08	6870365	102988336	32546411	90	36317											
HRAS	3265	broad.mit.edu	37	chr11	534288	534288	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgcactcttgcccacaccgCcggcgcccaccaccaccagc	7	3	8	23	4	1	0	0	0	1	0	1	0	1	0	7	1	2	1	7	1	0	1	rs104894230		TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:534288C>G	uc001lpv.2	-	2	223	c.35G>C	c.(34-36)GGC>GCC	p.G12A	HRAS_uc010qvw.1_Missense_Mutation_p.G12A|HRAS_uc010qvx.1_Missense_Mutation_p.G12A|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	12	GTP.		G -> S (in FCSS, OSCC and CMEMS).|G -> E (in FCSS).|G -> C (in FCSS).|G -> A (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12V(250)|p.G12S(54)|p.G12D(40)|p.G12C(23)|p.G12R(12)|p.G12A(7)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GCCCACACCGCCGGCGCCCAC	0.647	G12V(T24_URINARY_TRACT)|G12D(HS578T_BREAST)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			9	46					0	0	0	0	G	534288	G	G	534288	3	3	197	1	0	0	0	0	1	0	0	0	7387	739	26	4	617	4	HRAS	11	534288	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		534288	134472228	91	36318											
MUC5B	727897	broad.mit.edu	37	chr11	1283520	1283520	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccggggggcagtccaggAcccccagcagccactgaagg	9	3	14	15	1	0	1	0	1	0	0	2	2	2	2	5	5	2	2	5	5	1	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:1283520A>C	uc009ycr.1	+	72	18404	c.18278A>C	c.(18277-18279)GAC>GCC	p.D6093A		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:Variant_position_missing_in_Q9HC84_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCAGTCCAGGACCCCCAGCAG	0.657													11	91					0	0	0	0	C	1283520	C	C	1283520	3	2	197	1	0	0	0	0	1	0	0	0	10032	290	10	5		5	MUC5B	11	1283520	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	749232	1283520	133722996	92	36319											
OR56B1	387748	broad.mit.edu	37	chr11	5758256	5758256	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttgtcactccagtgcctgtGcttgcagcacagcgtgatta	7	13	10	11	1	1	1	1	1	0	0	2	1	2	1	2	0	5	3	2	0	1	3	rs149260229	by1000genomes	TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:5758256G>T	uc001mbt.1	+	1	510	c.510G>T	c.(508-510)GTG>GTT	p.V170V	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|OR56B1_uc001mbs.1_Silent_p.V170V|OR56B1_uc009yev.1_Silent_p.V170V	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		CAGTGCCTGTGCTTGCAGCAC	0.473													17	88					1.15088e-07	1.49482e-07	1	0	T	5758256	T	T	5758256	2	4	197	1	0	0	0	0	0	0	0	1	11191	1306	46	4		4	OR56B1	11	5758256	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08	4474736	5758256	129248260	93	36320											
LMO1	4004	broad.mit.edu	37	chr11	8252036	8252036	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcttccctttgggctggacgGagagcatcggcacgcctgca	6	8	14	13	3	0	1	0	0	0	1	2	3	1	2	2	4	2	5	2	4	0	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:8252036G>C	uc001mgg.1	-	2	538	c.41C>G	c.(40-42)TCC>TGC	p.S14C	LMO1_uc009yfo.1_RNA|LMO1_uc001mgh.1_Missense_Mutation_p.S13C	NM_002315	NP_002306	P25800	RBTN1_HUMAN	LIM domain only 1	14					cell proliferation|multicellular organismal development|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;1.59e-07)|BRCA - Breast invasive adenocarcinoma(625;0.203)		GGGCTGGACGGAGAGCATCGG	0.592			T|A	TRD@	T-ALL|neuroblastoma	neuroblastoma							15	143					0	0	0	0	C	8252036	C	C	8252036	3	2	197	1	0	0	0	0	1	0	0	0	8893	1174	41	2	441	2	LMO1	11	8252036	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	2493780	8252036	126754480	94	36321											
OR4C11	219429	broad.mit.edu	37	chr11	55371657	55371657	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcaagaatctgcaaaggAcaaataaaatagaaagaagt	24	5	8	4	0	1	3	0	0	1	3	1	4	1	4	0	1	2	2	0	1	10	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:55371657A>G	uc010rii.1	-	1	193	c.193T>C	c.(193-195)TCC>CCC	p.S65P		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCTGCAAAGGACAAATAAAAT	0.403													9	84					0	0	0	0	G	55371657	G	G	55371657	3	3	197	1	0	0	0	0	1	0	0	0	11099	275	10	5	741	5	OR4C11	11	55371657	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	47119621	55371657	79634859	95	36322											
SLC22A10	387775	broad.mit.edu	37	chr11	63066443	63066443	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaccaataaactagatgaGggcttaaaggcacttagaaa	18	8	8	7	0	1	3	1	1	0	2	1	3	1	3	1	2	1	2	1	2	8	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:63066443G>T	uc009yor.2	+	5	1090	c.882G>T	c.(880-882)GAG>GAT	p.E294D	SLC22A10_uc010rmo.1_RNA|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_Missense_Mutation_p.E134D	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	294	Extracellular (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						AACTAGATGAGGGCTTAAAGG	0.413													8	61					1.12685e-05	1.44698e-05	1	0	T	63066443	T	T	63066443	3	4	197	1	0	0	0	0	1	0	0	0	14506	991	35	4	900	4	SLC22A10	11	63066443	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	7694786	63066443	71940073	96	36323											
LTBP3	4054	broad.mit.edu	37	chr11	65319552	65319552	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaagggaaaagtcactctcGccctgaatggtgagcgtctg	12	8	12	9	2	3	2	1	2	2	0	4	3	3	3	1	2	1	0	1	2	5	0	rs111330939		TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:65319552G>A	uc001oej.2	-	8	1691	c.1422C>T	c.(1420-1422)GGC>GGT	p.G474G	LTBP3_uc001oeh.2_5'Flank|LTBP3_uc010roi.1_Silent_p.G357G|LTBP3_uc001oei.2_Silent_p.G474G|LTBP3_uc010roj.1_Silent_p.G175G|LTBP3_uc010rok.1_Silent_p.G385G	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	474						extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						AGTCACTCTCGCCCTGAATGG	0.597											OREG0021081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	136					0	0	0	0	A	65319552	A	A	65319552	2	1	197	1	0	0	0	0	0	0	0	1	9125	1074	38	1		1	LTBP3	11	65319552	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08	2253109	65319552	69686964	97	36324											
ARRB1	408	broad.mit.edu	37	chr11	74989766	74989766	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggggcatactgaaccttccGgatgaccagacgcacagaat	12	7	11	11	2	0	4	0	2	0	2	1	5	1	5	3	3	2	2	3	3	3	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:74989766G>A	uc001owe.1	-	8	727	c.505C>T	c.(505-507)CGG>TGG	p.R169W	ARRB1_uc001owf.1_Missense_Mutation_p.R169W	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	169				R->E: Constitutive active; enables phosphorylation-independent binding to GPCRs.	G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						TGAACCTTCCGGATGACCAGA	0.592													19	138					0	0	0	0	A	74989766	A	A	74989766	3	1	197	1	0	0	0	0	1	0	0	0	982	1115	39	1	787	1	ARRB1	11	74989766	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	9670214	74989766	60016750	98	36325											
GRM5	2915	broad.mit.edu	37	chr11	88583210	88583210	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgagcttcttcagcagctTatcaaagctctgctcccctg	7	13	8	13	0	4	1	2	1	2	0	5	1	5	1	2	0	5	5	2	0	2	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:88583210T>C	uc001pcq.2	-	2	975	c.775A>G	c.(775-777)AAG>GAG	p.K259E	GRM5_uc009yvm.2_Missense_Mutation_p.K259E	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	259	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TTCAGCAGCTTATCAAAGCTC	0.532													5	50					0	0	0	0	C	88583210	C	C	88583210	3	2	197	1	0	0	0	0	1	0	0	0	6839	1763	61	5	2895	5	GRM5	11	88583210	Missense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08	13593444	88583210	46423306	99	36326											
NAALAD2	10003	broad.mit.edu	37	chr11	89868742	89868742	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttaggctggtttattaagcCtctcaaagaaacgaccactt	12	12	7	10	1	1	1	1	0	1	1	2	2	1	1	2	2	2	2	2	2	5	5			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:89868742C>T	uc001pdf.3	+	2	207	c.98C>T	c.(97-99)CCT>CTT	p.P33L	NAALAD2_uc009yvx.2_Missense_Mutation_p.P33L|NAALAD2_uc009yvy.2_Missense_Mutation_p.P33L|NAALAD2_uc001pdd.2_Missense_Mutation_p.P33L|NAALAD2_uc001pde.2_Missense_Mutation_p.P33L	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	33	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TTTATTAAGCCTCTCAAAGAA	0.378													4	37					0	0	0	0	T	89868742	T	T	89868742	3	4	197	1	0	0	0	0	1	0	0	0	10181	681	24	4	104	4	NAALAD2	11	89868742	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	1285532	89868742	45137774	100	36327											
C2CD2L	9854	broad.mit.edu	37	chr11	118984985	118984985	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagacgagacaacccgttcgGatatttctgagaggccatct	11	9	10	11	3	2	3	0	1	2	3	3	6	2	4	2	2	1	1	2	2	2	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:118984985G>T	uc001pvo.2	+	13	2178	c.1819G>T	c.(1819-1821)GAT>TAT	p.D607Y	C2CD2L_uc001pvn.2_Missense_Mutation_p.D608Y	NM_014807	NP_055622	O14523	C2C2L_HUMAN	transmembrane protein 24	607						integral to membrane					0						AACCCGTTCGGATATTTCTGA	0.572													11	142					1.08611e-07	1.41885e-07	1	0	T	118984985	T	T	118984985	3	4	197	1	0	0	0	0	1	0	0	0	2163	1174	41	2	1872	2	C2CD2L	11	118984985	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	29116243	118984985	16021531	101	36328											
PANX3	116337	broad.mit.edu	37	chr11	124487352	124487352	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatccggcagaagagttcCgacccctatgtgttctggaa	11	9	11	10	2	1	3	0	0	1	3	3	5	3	4	4	2	0	3	4	2	4	3	rs147550190		TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr11:124487352C>T	uc001qah.2	+	3	507	c.507C>T	c.(505-507)TCC>TCT	p.S169S		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	169	Cytoplasmic (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		AGAAGAGTTCCGACCCCTATG	0.458													19	105					0	0	0	0	T	124487352	T	T	124487352	2	4	197	1	0	0	0	0	0	0	0	1	11476	639	23	1		1	PANX3	11	124487352	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	5502367	124487352	10519164	102	36329											
GALNT8	26290	broad.mit.edu	37	chr12	4874614	4874614	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagaggccagtgctagtgatCgctgcctgacagaccctggc	8	7	13	13	1	0	4	0	2	0	2	1	4	0	4	3	2	2	2	3	2	1	1	rs148196108		TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:4874614C>T	uc001qne.1	+	10	1755	c.1663C>T	c.(1663-1665)CGC>TGC	p.R555C		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	555	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						TGCTAGTGATCGCTGCCTGAC	0.438													4	47					0	0	0	0	T	4874614	T	T	4874614	3	4	197	1	0	0	0	0	1	0	0	0	6254	884	31	1	1701	1	GALNT8	12	4874614	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		4874614	128977281	103	36330											
PZP	5858	broad.mit.edu	37	chr12	9304243	9304243	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttgttgctcacttctgtcCggctcacagagctagatctt	6	14	10	11	1	4	2	2	0	2	2	5	2	5	2	1	2	2	5	1	2	1	5			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:9304243C>T	uc001qvl.2	-	33	4267	c.4238G>A	c.(4237-4239)CGG>CAG	p.R1413Q	PZP_uc009zgl.2_Missense_Mutation_p.R1199Q	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						CACTTCTGTCCGGCTCACAGA	0.443													5	33					0	0	0	0	T	9304243	T	T	9304243	3	4	197	1	0	0	0	0	1	0	0	0	12934	652	23	1	226	1	PZP	12	9304243	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	4429629	9304243	124547652	104	36331											
MRPS35	60488	broad.mit.edu	37	chr12	27869315	27869315	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atttaaaccctctgcagtacCtcttcctgttcgaatgggtt	8	15	7	11	1	2	0	0	0	2	0	4	1	3	0	3	1	3	4	3	1	4	6			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:27869315C>T	uc001rih.2	+	3	293	c.245C>T	c.(244-246)CCT>CTT	p.P82L	MRPS35_uc001rii.2_Missense_Mutation_p.P82L	NM_021821	NP_068593	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35 precursor	82					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit					0	Lung SC(9;0.0873)					TCTGCAGTACCTCTTCCTGTT	0.448													5	42					0	0	0	0	T	27869315	T	T	27869315	3	4	197	1	0	0	0	0	1	0	0	0	9897	681	24	4	255	4	MRPS35	12	27869315	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	18565072	27869315	105982580	105	36332											
PUS7L	83448	broad.mit.edu	37	chr12	44148515	44148515	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatggaaatttctgcctaatGgcactgtgtaaactagccct	12	12	8	9	0	1	0	0	0	1	0	1	1	1	1	2	2	3	2	2	2	6	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:44148515G>A	uc001rnq.3	-	2	1023	c.534C>T	c.(532-534)GCC>GCT	p.A178A	PUS7L_uc001rnr.3_Silent_p.A178A|PUS7L_uc001rns.3_Silent_p.A178A|PUS7L_uc009zkb.2_Intron	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	178					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TCTGCCTAATGGCACTGTGTA	0.358													10	83					0	0	0	0	A	44148515	A	A	44148515	2	1	197	1	0	0	0	0	0	0	0	1	12899	1335	47	4		4	PUS7L	12	44148515	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08	16279200	44148515	89703380	106	36333											
PCBP2	5094	broad.mit.edu	37	chr12	53854894	53854895	+	Frame_Shift_Del	DEL	GT	-	-																															attccacaatccatcattgaGtgtgtcaaacagatctgcgt																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:53854894_53854895delGT	uc001sdl.3	+	7	821_822	c.471_472delGT	c.(469-474)GAGTGTfs	p.E157fs	PCBP2_uc001sdc.3_Frame_Shift_Del_p.E157fs|PCBP2_uc001sdb.3_Frame_Shift_Del_p.E157fs|PCBP2_uc001sde.3_Frame_Shift_Del_p.E157fs|PCBP2_uc001sdi.3_Frame_Shift_Del_p.E157fs|PCBP2_uc001sdd.3_Frame_Shift_Del_p.E157fs|PCBP2_uc001sdf.3_Frame_Shift_Del_p.E157fs|PCBP2_uc009zna.2_Frame_Shift_Del_p.E118fs|PCBP2_uc010soi.1_5'Flank|PCBP2_uc001sdj.3_5'Flank|PCBP2_uc010soj.1_5'Flank|PCBP2_uc001sdk.3_5'Flank|PCBP2_uc010soh.1_Frame_Shift_Del_p.E157fs|PCBP2_uc009zmz.1_Frame_Shift_Del_p.E99fs|PCBP2_uc001sdg.1_RNA	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	157_158	KH 2.				innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						CCATCATTGAGTGTGTCAAACA	0.53													---	---	---								-	53854895	-	-	53854894	7	5	197	1	0	1	0	1	0	0	0	0	11555	1020	36	0	493	0	PCBP2	12	53854894	Frame_Shift_Del	DEL	GT	TCGA-CV-6938-01A-11D-1912-08	9706379	53854894	79997001	107	36334											
DNAJC14	85406	broad.mit.edu	37	chr12	56221562	56221562	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccccctaaccgccctgtcCacactcccatccaaactcga	10	6	4	21	2	0	0	0	0	0	0	4	1	3	0	7	0	3	0	7	0	2	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:56221562C>T	uc001shx.1	-	2	1085	c.881G>A	c.(880-882)TGG>TAG	p.W294*	DNAJC14_uc001shu.1_Nonsense_Mutation_p.W294*|DNAJC14_uc009zob.1_Nonsense_Mutation_p.W294*|DNAJC14_uc001shy.1_Nonsense_Mutation_p.W294*	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	294					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						CCGCCCTGTCCACACTCCCAT	0.498													9	89					0	0	0	0	T	56221562	T	T	56221562	4	4	197	1	0	0	0	0	0	1	0	0	4655	595	21	4	1251	4	DNAJC14	12	56221562	Nonsense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	2366668	56221562	77630333	108	36335											
GAS2L3	283431	broad.mit.edu	37	chr12	100995424	100995424	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atatgtttttaggtattaaaGttaaggcagaaaaattattg	16	16	8	1	0	0	1	0	0	0	1	0	1	0	1	0	2	0	4	0	2	9	9			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:100995424G>A	uc001thu.2	+	5	422	c.196G>A	c.(196-198)GTT>ATT	p.V66I	GAS2L3_uc009zty.2_Missense_Mutation_p.V66I|GAS2L3_uc001thv.2_5'UTR	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	66	CH.				cell cycle arrest					skin(1)	1						AGGTATTAAAGTTAAGGCAGA	0.269													11	82					0	0	0	0	A	100995424	A	A	100995424	3	1	197	1	0	0	0	0	1	0	0	0	6283	1029	36	4	206	4	GAS2L3	12	100995424	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	44773862	100995424	32856471	109	36336											
GAS2L3	283431	broad.mit.edu	37	chr12	101017977	101017977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacacttttgccaaataagtGttcaggaaaaactcaaccta	16	10	5	10	0	2	0	2	0	0	0	2	1	2	1	2	1	3	1	2	1	6	5			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:101017977G>A	uc001thu.2	+	10	1620	c.1394G>A	c.(1393-1395)TGT>TAT	p.C465Y	GAS2L3_uc009zty.2_Missense_Mutation_p.C465Y|GAS2L3_uc001thv.2_Missense_Mutation_p.C361Y	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	465					cell cycle arrest					skin(1)	1						CCAAATAAGTGTTCAGGAAAA	0.403													8	94					0	0	0	0	A	101017977	A	A	101017977	3	1	197	1	0	0	0	0	1	0	0	0	6283	1377	48	4	1424	4	GAS2L3	12	101017977	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	22553	101017977	32833918	110	36337											
TCP11L2	255394	broad.mit.edu	37	chr12	106708250	106708250	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagaactttcaattgaaacAagaggctctcccagaaaaga	17	8	8	8	0	2	5	1	2	1	4	3	6	2	5	1	1	2	1	1	1	6	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:106708250A>G	uc001tln.2	+	3	446	c.272A>G	c.(271-273)CAA>CGA	p.Q91R	TCP11L2_uc001tll.2_Missense_Mutation_p.Q91R|TCP11L2_uc001tlm.2_Missense_Mutation_p.Q91R	NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	91										ovary(3)	3						CAATTGAAACAAGAGGCTCTC	0.323													8	44					0	0	0	0	G	106708250	G	G	106708250	3	3	197	1	0	0	0	0	1	0	0	0	15781	130	5	5	278	5	TCP11L2	12	106708250	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	5690273	106708250	27143645	111	36338											
RASAL1	8437	broad.mit.edu	37	chr12	113553852	113553852	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcgcagggcacccaggtTccccctgtccaggatcagat	8	7	10	16	1	1	1	1	0	0	1	4	2	3	2	4	3	0	3	4	3	0	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:113553852T>C	uc001tum.1	-	10	1029	c.736A>G	c.(736-738)AAC>GAC	p.N246D	RASAL1_uc010syp.1_Missense_Mutation_p.N246D|RASAL1_uc001tul.2_Missense_Mutation_p.N246D|RASAL1_uc001tun.1_Missense_Mutation_p.N246D|RASAL1_uc010syq.1_Missense_Mutation_p.N246D|RASAL1_uc001tuo.3_Missense_Mutation_p.N246D|RASAL1_uc010syr.1_Missense_Mutation_p.N246D	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	246					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						GCACCCAGGTTCCCCCTGTCC	0.393													4	51					0	0	0	0	C	113553852	C	C	113553852	3	2	197	1	0	0	0	0	1	0	0	0	13128	1783	62	5	1730	5	RASAL1	12	113553852	Missense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08	6845602	113553852	20298043	112	36339											
CCDC60	160777	broad.mit.edu	37	chr12	119978433	119978435	+	In_Frame_Del	DEL	CAT	-	-																															tcacagtttgtgcgagaacaCatcatccatatgcctcaaga																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:119978433_119978435delCAT	uc001txe.2	+	14	2031_2033	c.1566_1568delCAT	c.(1564-1569)CACATC>CAC	p.I524del	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	524										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		TGCGAGAACACATCATCCATATG	0.527													---	---	---								-	119978435	-	-	119978433	7	5	197	1	0	1	0	1	0	0	0	0	2844	477	17	0	1620	0	CCDC60	12	119978433	In_Frame_Del	DEL	CAT	TCGA-CV-6938-01A-11D-1912-08	6424581	119978433	13873462	113	36340											
KDM2B	84678	broad.mit.edu	37	chr12	122012498	122012498	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgaaatcagggtcaggcatCctggggaaagaggagcacag	13	5	16	7	0	2	2	2	1	0	1	3	4	3	4	1	5	1	2	1	5	2	0			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:122012498C>T	uc001uat.2	-	4	455	c.351G>A	c.(349-351)AAG>AAA	p.K117K	KDM2B_uc001uas.2_Silent_p.K86K|KDM2B_uc001uau.2_5'UTR|KDM2B_uc001uav.3_Silent_p.K117K	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	117					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						GGTCAGGCATCCTGGGGAAAG	0.542													6	66					0	0	0	0	T	122012498	T	T	122012498	2	4	197	1	0	0	0	0	0	0	0	1	8164	869	30	2		2	KDM2B	12	122012498	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	2034065	122012498	11839397	114	36341											
WDR66	144406	broad.mit.edu	37	chr12	122386953	122386953	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcaatagtaaaacacgggcaAtatattatgcatgggtaagc	16	9	10	6	1	0	0	0	0	0	0	0	0	0	0	0	2	3	5	0	2	9	6			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr12:122386953A>G	uc009zxk.2	+	8	1397	c.1255A>G	c.(1255-1257)ATA>GTA	p.I419V		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	419	WD 3.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		AACACGGGCAATATATTATGC	0.274													7	59					0	0	0	0	G	122386953	G	G	122386953	3	3	197	1	0	0	0	0	1	0	0	0	17385	101	4	5	1281	5	WDR66	12	122386953	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	374455	122386953	11464942	115	36342											
PABPC3	5042	broad.mit.edu	37	chr13	25671496	25671496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagtatatgcagagaatggCaagtgtacgagctgtgccca	12	8	13	8	2	0	1	0	0	0	1	0	4	0	1	1	1	4	5	1	1	5	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr13:25671496C>T	uc001upy.2	+	1	1221	c.1160C>T	c.(1159-1161)GCA>GTA	p.A387V		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	387					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CAGAGAATGGCAAGTGTACGA	0.502													11	122					0	0	0	0	T	25671496	T	T	25671496	3	4	197	1	0	0	0	0	1	0	0	0	11419	710	25	4	1162	4	PABPC3	13	25671496	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		25671496	89498382	116	36343											
FLT1	2321	broad.mit.edu	37	chr13	28895620	28895620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atctccttttctcacataatCggggttcttataaatatccc	10	16	4	11	1	3	0	1	0	3	0	7	0	4	0	2	2	0	1	2	2	5	7			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr13:28895620C>T	uc001usb.3	-	23	3439	c.3154G>A	c.(3154-3156)GAT>AAT	p.D1052N	FLT1_uc010aap.2_Missense_Mutation_p.D57N|FLT1_uc010aaq.2_Missense_Mutation_p.D177N|FLT1_uc001usa.3_Missense_Mutation_p.D270N	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1052	Cytoplasmic (Potential).|Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTCACATAATCGGGGTTCTTA	0.393													5	110					0	0	0	0	T	28895620	T	T	28895620	3	4	197	1	0	0	0	0	1	0	0	0	5973	884	31	1	894	1	FLT1	13	28895620	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	3224124	28895620	86274258	117	36344											
SERP2	387923	broad.mit.edu	37	chr13	44953805	44953807	+	In_Frame_Del	DEL	GAC	-	-																															agaggagaaatatcctgtggGaccatggctgttggcactgt																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr13:44953805_44953807delGAC	uc001uzj.2	+	2	297_299	c.113_115delGAC	c.(112-117)GGACCA>GCA	p.38_39GP>A	SERP2_uc001uzk.2_RNA	NM_001010897	NP_001010897	Q8N6R1	SERP2_HUMAN	stress-associated endoplasmic reticulum protein	38_39	Helical; Anchor for type IV membrane protein; (Potential).				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane					0		all_hematologic(4;1.49e-06)|Acute lymphoblastic leukemia(4;1.5e-06)|Lung NSC(96;0.00043)|Breast(139;0.0044)|Prostate(109;0.0137)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;0.00026)|BRCA - Breast invasive adenocarcinoma(63;0.123)		TATCCTGTGGGACCATGGCTGTT	0.355													---	---	---								-	44953807	-	-	44953805	7	5	197	1	0	1	0	1	0	0	0	0	14150	1174	41	0	119	0	SERP2	13	44953805	In_Frame_Del	DEL	GAC	TCGA-CV-6938-01A-11D-1912-08	16058185	44953805	70216073	118	36345											
CPB2	1361	broad.mit.edu	37	chr13	46627851	46627851	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcaagaatccgtatgtGcccgtatctcgaagttcaat	11	10	10	10	3	2	1	1	0	1	1	4	2	3	1	2	1	2	5	2	1	6	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr13:46627851G>A	uc001vaw.2	-	11	1237	c.1170C>T	c.(1168-1170)GGC>GGT	p.G390G	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Intron|ZC3H13_uc001vas.1_5'Flank|ZC3H13_uc001vat.1_5'Flank	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	390					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		ATCCGTATGTGCCCGTATCTC	0.438													12	70					0	0	0	0	A	46627851	A	A	46627851	2	1	197	1	0	0	0	0	0	0	0	1	3812	1306	46	4		4	CPB2	13	46627851	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1674046	46627851	68542027	119	36346											
PCDH17	27253	broad.mit.edu	37	chr13	58208829	58208829	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgactctgagcactatctccAtcatcctcctagcggccatg	8	11	7	15	1	3	2	1	2	2	0	6	2	5	2	4	1	2	1	4	1	2	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr13:58208829A>G	uc001vhq.1	+	1	3041	c.2149A>G	c.(2149-2151)ATC>GTC	p.I717V	PCDH17_uc010aec.1_Missense_Mutation_p.I717V	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	717	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CACTATCTCCATCATCCTCCT	0.607													7	71					0	0	0	0	G	58208829	G	G	58208829	3	3	197	1	0	0	0	0	1	0	0	0	11566	217	8	5	2151	5	PCDH17	13	58208829	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	11580978	58208829	56961049	120	36347											
DIAPH3	81624	broad.mit.edu	37	chr13	60544103	60544103	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttggcaacaaaatgtattCtcaagtttacaaagcaaatc	16	12	6	7	0	1	0	1	0	1	0	3	0	1	0	0	1	3	5	0	1	8	5			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr13:60544103C>G	uc001vht.2	-	17	2268	c.2049G>C	c.(2047-2049)GAG>GAC	p.E683D	DIAPH3_uc001vhu.2_Missense_Mutation_p.E420D|DIAPH3_uc001vhv.2_Missense_Mutation_p.E261D	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	683	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AAAATGTATTCTCAAGTTTAC	0.254													3	19					0	0	0	0	G	60544103	G	G	60544103	3	3	197	1	0	0	0	0	1	0	0	0	4542	912	32	2	1600	2	DIAPH3	13	60544103	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	2335274	60544103	54625775	121	36348											
EDNRB	1910	broad.mit.edu	37	chr13	78492516	78492516	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctccgcaggtgccaacgAccgcgccagactggcgttgg	7	5	13	16	5	0	1	0	0	0	1	1	2	1	1	5	3	2	2	5	3	1	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr13:78492516A>T	uc001vko.2	-	1	451	c.193T>A	c.(193-195)TCG>ACG	p.S65T	uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Missense_Mutation_p.S65T|EDNRB_uc010aez.1_Missense_Mutation_p.S65T|EDNRB_uc001vkp.1_Missense_Mutation_p.S148T|EDNRB_uc010afa.1_Missense_Mutation_p.S65T	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	65	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GGTGCCAACGACCGCGCCAGA	0.622													8	82					0	0	0	0	T	78492516	T	T	78492516	3	4	197	1	0	0	0	0	1	0	0	0	4942	275	10	5	1284	5	EDNRB	13	78492516	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	17948413	78492516	36677362	122	36349											
ZIC2	7546	broad.mit.edu	37	chr13	100635244	100635244	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctgggaggagtgtccgcGcgagggcaagcccttcaagg	7	7	16	11	3	2	0	1	0	1	0	3	3	3	2	2	4	1	1	2	4	2	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr13:100635244G>C	uc001von.2	+	1	926	c.926G>C	c.(925-927)CGC>CCC	p.R309P		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	309	C2H2-type 2; atypical.				brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GAGTGTCCGCGCGAGGGCAAG	0.622													15	127					0	0	0	0	C	100635244	C	C	100635244	3	2	197	1	0	0	0	0	1	0	0	0	17746	1087	38	3	928	3	ZIC2	13	100635244	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	22142728	100635244	14534634	123	36350											
COL4A1	1282	broad.mit.edu	37	chr13	110827095	110827095	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aacccgctatcccttgatctCcctgcaagtaaaagtcaggc	11	9	7	14	1	2	1	1	1	1	0	4	1	3	1	3	1	2	3	3	1	5	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr13:110827095C>T	uc001vqw.3	-	38	3322	c.3200G>A	c.(3199-3201)GGA>GAA	p.G1067E	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1067	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCCTTGATCTCCCTGCAAGTA	0.463													32	257					0	0	0	0	T	110827095	T	T	110827095	3	4	197	1	0	0	0	0	1	0	0	0	3704	869	30	2	1869	2	COL4A1	13	110827095	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	10191851	110827095	4342783	124	36351											
METT11D1	64745	broad.mit.edu	37	chr14	21464803	21464803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaaacggcctcgccatgtgCattgtcacttgtgctgtcca	7	13	9	12	2	1	0	1	0	0	0	3	0	2	0	3	1	3	2	3	1	2	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr14:21464803C>T	uc001vyn.2	+	13	1395	c.1198C>T	c.(1198-1200)CAT>TAT	p.H400Y	METT11D1_uc001vym.2_Missense_Mutation_p.H400Y|METT11D1_uc001vyo.2_Missense_Mutation_p.H400Y|METT11D1_uc001vyp.2_Missense_Mutation_p.H242Y|METT11D1_uc001vyq.2_Missense_Mutation_p.H242Y|SLC39A2_uc001vyr.2_5'Flank|SLC39A2_uc001vys.2_5'Flank	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	400					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TCGCCATGTGCATTGTCACTT	0.577													7	77					0	0	0	0	T	21464803	T	T	21464803	3	4	197	1	0	0	0	0	1	0	0	0	9544	710	25	4	1248	4	METT11D1	14	21464803	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		21464803	85884737	125	36352											
LRP10	26020	broad.mit.edu	37	chr14	23346570	23346570	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggagtggtgcaggccctgcGaggccgcctgttgcccagcc	4	7	16	14	2	0	0	0	0	0	0	0	2	0	1	5	4	4	2	5	4	0	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr14:23346570G>A	uc001whd.2	+	7	2529	c.1976G>A	c.(1975-1977)CGA>CAA	p.R659Q	LRP10_uc001whe.2_Intron	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	659	Pro-rich.|Cytoplasmic (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		CAGGCCCTGCGAGGCCGCCTG	0.667													11	91					0	0	0	0	A	23346570	A	A	23346570	3	1	197	1	0	0	0	0	1	0	0	0	9002	1058	37	1	2002	1	LRP10	14	23346570	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1881767	23346570	84002970	126	36353											
CDH24	64403	broad.mit.edu	37	chr14	23524268	23524268	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagagctggggtgctcacCgacattggacatctcgggca	8	9	13	11	2	3	1	2	0	1	1	4	3	3	2	1	4	2	3	1	4	0	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr14:23524268C>T	uc001wil.2	-	3	756	c.496G>A	c.(496-498)GGG>AGG	p.G166R	CDH24_uc010akf.2_Missense_Mutation_p.G166R|CDH24_uc001win.3_Missense_Mutation_p.G166R	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	166	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GGGTGCTCACCGACATTGGAC	0.552											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	107					0	0	0	0	T	23524268	T	T	23524268	3	4	197	1	0	0	0	0	1	0	0	0	3124	666	23	1	2007	1	CDH24	14	23524268	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	177698	23524268	83825272	127	36354											
YLPM1	56252	broad.mit.edu	37	chr14	75277087	75277087	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttattgactatgaccgggAtcgatttgacagagaacgcc	11	11	11	8	3	0	4	0	3	0	1	1	7	0	5	2	1	1	1	2	1	3	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr14:75277087A>G	uc001xqj.3	+	9	5316	c.5192A>G	c.(5191-5193)GAT>GGT	p.D1731G	YLPM1_uc001xql.3_RNA|YLPM1_uc001xqm.1_Missense_Mutation_p.D214G	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1536	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		TATGACCGGGATCGATTTGAC	0.403													3	115					0	0	0	0	G	75277087	G	G	75277087	3	3	197	1	0	0	0	0	1	0	0	0	17554	333	12	5	5226	5	YLPM1	14	75277087	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	51752819	75277087	32072453	128	36355											
C14orf179	112752	broad.mit.edu	37	chr14	76452140	76452140	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgcggagatggaggattTgctcgacttggacgaggagc	8	7	18	8	4	0	1	0	0	0	1	1	8	0	5	1	6	2	1	1	6	0	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr14:76452140T>A	uc010asm.1	+	1	45	c.11T>A	c.(10-12)TTG>TAG	p.L4*	C14orf179_uc001xsf.2_RNA|C14orf179_uc010asl.1_Nonsense_Mutation_p.L4*|C14orf179_uc001xsg.2_Nonsense_Mutation_p.L4*|C14orf179_uc010tve.1_RNA|C14orf179_uc001xse.2_Nonsense_Mutation_p.L4*	NM_001102564	NP_001096034	Q96FT9	IFT43_HUMAN	hypothetical protein LOC112752 isoform 2	4					cilium morphogenesis|intraflagellar retrograde transport						0				BRCA - Breast invasive adenocarcinoma(234;0.0199)		ATGGAGGATTTGCTCGACTTG	0.627													5	44					0	0	0	0	A	76452140	A	A	76452140	4	1	197	1	0	0	0	0	0	1	0	0	1768	1821	63	5	13	5	C14orf179	14	76452140	Nonsense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08	1175053	76452140	30897400	129	36356											
MAPKBP1	23005	broad.mit.edu	37	chr15	42115756	42115756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgatggccgtccgtctcGgcctcactcctatcagaacc	7	9	9	16	3	3	2	2	1	1	1	6	2	5	2	5	2	2	1	5	2	2	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr15:42115756G>A	uc001zok.3	+	30	4014	c.3728G>A	c.(3727-3729)CGG>CAG	p.R1243Q	MAPKBP1_uc001zoj.3_Missense_Mutation_p.R1237Q|MAPKBP1_uc010bcj.2_Missense_Mutation_p.R744Q|MAPKBP1_uc010bci.2_Intron|MAPKBP1_uc010udb.1_Missense_Mutation_p.R1076Q|MAPKBP1_uc010bck.2_Missense_Mutation_p.R454Q|MAPKBP1_uc010bcl.2_Missense_Mutation_p.R744Q	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	1243										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CGTCCGTCTCGGCCTCACTCC	0.622													8	56					0	0	0	0	A	42115756	A	A	42115756	3	1	197	1	0	0	0	0	1	0	0	0	9345	1116	39	1	3842	1	MAPKBP1	15	42115756	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08		42115756	60415636	130	36357											
TCF12	6938	broad.mit.edu	37	chr15	57565366	57565366	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagagcttggccgaatgtgTcagcttcacttgaagagtga	12	10	12	7	1	2	4	2	2	0	2	2	5	2	4	1	1	2	2	1	1	3	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr15:57565366T>A	uc002aec.2	+	18	2096	c.1812T>A	c.(1810-1812)TGT>TGA	p.C604*	TCF12_uc010ugm.1_Nonsense_Mutation_p.C656*|TCF12_uc010ugn.1_Nonsense_Mutation_p.C624*|TCF12_uc002aea.2_Nonsense_Mutation_p.C628*|TCF12_uc010bfs.2_Nonsense_Mutation_p.C25*|TCF12_uc002aeb.2_Nonsense_Mutation_p.C628*|TCF12_uc002aed.2_Nonsense_Mutation_p.C604*|TCF12_uc002aee.2_Nonsense_Mutation_p.C434*|TCF12_uc010bft.2_Nonsense_Mutation_p.C458*|TCF12_uc010ugo.1_Nonsense_Mutation_p.C368*|TCF12_uc010ugp.1_Nonsense_Mutation_p.C261*|TCF12_uc010ugq.1_Nonsense_Mutation_p.C238*|TCF12_uc010ugr.1_Nonsense_Mutation_p.C217*	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	604	Helix-loop-helix motif.				immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		GCCGAATGTGTCAGCTTCACT	0.458			T	TEC	extraskeletal myxoid chondrosarcoma								17	85					0	0	0	0	A	57565366	A	A	57565366	4	1	197	1	0	0	0	0	0	1	0	0	15753	1673	58	5	2027	5	TCF12	15	57565366	Nonsense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08	15449610	57565366	44966026	131	36358											
ALDH1A2	8854	broad.mit.edu	37	chr15	58357758	58357758	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtacttaatttcgagattggGcgtgggcgacggcaggaggt	8	10	17	6	4	0	1	0	0	0	1	1	4	0	2	0	5	1	2	0	5	2	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr15:58357758G>C	uc002aex.2	-	1	149	c.91C>G	c.(91-93)CCC>GCC	p.P31A	ALDH1A2_uc002aey.2_Missense_Mutation_p.P31A|ALDH1A2_uc010ugv.1_5'UTR|ALDH1A2_uc010ugw.1_Intron	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	31					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TCGAGATTGGGCGTGGGCGAC	0.627													4	53					0	0	0	0	C	58357758	C	C	58357758	3	2	197	1	0	0	0	0	1	0	0	0	491	1203	42	4	1517	4	ALDH1A2	15	58357758	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	792392	58357758	44173634	132	36359											
CHSY1	22856	broad.mit.edu	37	chr15	101719015	101719015	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtgcagctgtattgtgcgAtggcggagctcggatatctt	6	12	15	8	4	1	0	0	0	1	0	2	3	1	2	0	4	4	4	0	4	2	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr15:101719015A>G	uc002bwt.1	-	4	1470	c.987T>C	c.(985-987)CAT>CAC	p.H329H	CHSY1_uc010usd.1_Silent_p.H57H	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	329	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTATTGTGCGATGGCGGAGCT	0.498													9	79					0	0	0	0	G	101719015	G	G	101719015	2	3	197	1	0	0	0	0	0	0	0	1	3427	330	12	5		5	CHSY1	15	101719015	Silent	SNP	A	TCGA-CV-6938-01A-11D-1912-08	43361257	101719015	812377	133	36360											
PTX4	390667	broad.mit.edu	37	chr16	1537772	1537772	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgtgtctactttccggcctCggcgctgcagcttcctcacc	3	11	10	17	4	2	0	1	0	1	0	5	0	4	0	4	2	3	3	4	2	1	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr16:1537772C>T	uc010uvf.1	-	2	326	c.326G>A	c.(325-327)CGA>CAA	p.R109Q		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	114						extracellular region	metal ion binding				0						TTTCCGGCCTCGGCGCTGCAG	0.687													13	77					0	0	0	0	T	1537772	T	T	1537772	3	4	197	1	0	0	0	0	1	0	0	0	12888	884	31	1	1102	1	PTX4	16	1537772	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		1537772	88816981	134	36361											
MEFV	4210	broad.mit.edu	37	chr16	3296524	3296524	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caccacaggacctcgctgtaCctgtgcaagatgtctccaat	10	9	8	14	1	1	1	0	0	1	1	3	2	1	2	4	1	2	3	4	1	3	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr16:3296524C>T	uc002cun.1	-	6	1650	c.1610_splice	c.e6+1	p.R537_splice		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein						inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	CCTCGCTGTACCTGTGCAAGA	0.567													4	40					0	0	0	0	T	3296524	T	T	3296524	5	4	197	1	0	0	0	0	0	0	1	0	9512	521	18	4	754	4	MEFV	16	3296524	Splice_Site	SNP	C	TCGA-CV-6938-01A-11D-1912-08	1758752	3296524	87058229	135	36362											
ATF7IP2	80063	broad.mit.edu	37	chr16	10524589	10524589	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcaaggaatgttgaagcgCtgaaaacagcaattgggagt	15	8	13	5	1	1	2	1	2	0	0	1	4	1	4	0	2	3	3	0	2	6	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr16:10524589C>T	uc002czu.2	+	3	339	c.112C>T	c.(112-114)CTG>TTG	p.L38L	ATF7IP2_uc002czv.2_Silent_p.L38L|ATF7IP2_uc010uyo.1_RNA|ATF7IP2_uc010uyp.1_Intron|ATF7IP2_uc002czw.2_Silent_p.L38L|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	38					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						TGTTGAAGCGCTGAAAACAGC	0.408													5	35					0	0	0	0	T	10524589	T	T	10524589	2	4	197	1	0	0	0	0	0	0	0	1	1090	796	28	4		4	ATF7IP2	16	10524589	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	7228065	10524589	79830164	136	36363											
DNAH3	55567	broad.mit.edu	37	chr16	20990733	20990733	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctcttgcctcttgctattCaggagcgtcttgaaggttag	7	14	10	10	1	4	1	1	1	3	0	4	2	4	2	2	2	3	2	2	2	3	6			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr16:20990733C>G	uc010vbe.1	-	50	7995	c.7995G>C	c.(7993-7995)CTG>CTC	p.L2665L	DNAH3_uc010vbd.1_Silent_p.L100L	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2665	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCTTGCTATTCAGGAGCGTCT	0.468													8	91					0	0	0	0	G	20990733	G	G	20990733	2	3	197	1	0	0	0	0	0	0	0	1	4625	813	29	2		2	DNAH3	16	20990733	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	10466144	20990733	69364020	137	36364											
ARMC5	79798	broad.mit.edu	37	chr16	31477646	31477646	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcccctgtcccagctccCgacctgcacttcctgctgga	5	8	8	20	1	0	0	0	0	0	0	3	2	3	1	7	1	4	3	7	1	0	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr16:31477646C>T	uc002ecc.2	+	6	2773	c.2244C>T	c.(2242-2244)CCC>CCT	p.P748P	ARMC5_uc010vfn.1_Silent_p.P843P|ARMC5_uc010vfo.1_Silent_p.P780P|ARMC5_uc002eca.3_3'UTR|ARMC5_uc010vfp.1_Silent_p.P556P|ARMC5_uc002ecb.2_3'UTR	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	748	BTB.						binding			pancreas(1)	1						TCCCAGCTCCCGACCTGCACT	0.667													3	32					0	0	0	0	T	31477646	T	T	31477646	2	4	197	1	0	0	0	0	0	0	0	1	956	639	23	1		1	ARMC5	16	31477646	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	10486913	31477646	58877107	138	36365											
ADCY7	113	broad.mit.edu	37	chr16	50347892	50347892	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctactgaagcccaagttcagCggcgtggagaagatcaagac	13	6	12	10	2	2	4	2	1	0	3	2	5	2	4	1	2	3	1	1	2	5	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr16:50347892C>T	uc002egd.1	+	22	3043	c.2775C>T	c.(2773-2775)AGC>AGT	p.S925S		NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	925	Cytoplasmic (Potential).|Guanylate cyclase 2.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CCAAGTTCAGCGGCGTGGAGA	0.617													6	57					0	0	0	0	T	50347892	T	T	50347892	2	4	197	1	0	0	0	0	0	0	0	1	299	767	27	1		1	ADCY7	16	50347892	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	18870246	50347892	40006861	139	36366											
CTCF	10664	broad.mit.edu	37	chr16	67670670	67670670	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgaacctgagccagagcctCagcctgtgaccccagcccca	9	6	9	17	0	1	4	1	3	0	1	1	4	1	4	8	0	5	0	8	0	1	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr16:67670670C>T	uc002etl.2	+	11	2205	c.1915C>T	c.(1915-1917)CAG>TAG	p.Q639*	CTCF_uc010cek.2_Nonsense_Mutation_p.Q311*|CTCF_uc002etm.1_Nonsense_Mutation_p.Q128*	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	639					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		GCCAGAGCCTCAGCCTGTGAC	0.547													24	182					0	0	0	0	T	67670670	T	T	67670670	4	4	197	1	0	0	0	0	0	1	0	0	4017	827	29	2	1949	2	CTCF	16	67670670	Nonsense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	17322778	67670670	22684083	140	36367											
PHLPP2	23035	broad.mit.edu	37	chr16	71718486	71718486	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagcaagggagtattgccGtcgcttcacttcttctatct	9	13	9	10	2	4	0	1	0	3	0	5	2	4	1	1	1	2	3	1	1	4	6			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr16:71718486G>A	uc002fax.2	-	4	634	c.628C>T	c.(628-630)CGG>TGG	p.R210W	PHLPP2_uc002fav.2_5'Flank|PHLPP2_uc010cgf.2_Missense_Mutation_p.R210W|PHLPP2_uc002fay.1_Missense_Mutation_p.R210W	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	210	PH.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						GAGTATTGCCGTCGCTTCACT	0.478													8	37					0	0	0	0	A	71718486	A	A	71718486	3	1	197	1	0	0	0	0	1	0	0	0	11910	1144	40	1	3403	1	PHLPP2	16	71718486	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	4047816	71718486	18636267	141	36368											
CNTNAP4	85445	broad.mit.edu	37	chr16	76482788	76482788	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtcaacttcacagtggaCgaacacaggcatcatttcca	14	8	7	12	1	3	0	3	0	0	0	4	2	4	1	1	2	2	1	1	2	3	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr16:76482788C>T	uc002feu.1	+	8	1252	c.867C>T	c.(865-867)GAC>GAT	p.D289D	CNTNAP4_uc002fev.1_Silent_p.D201D|CNTNAP4_uc010chb.1_Silent_p.D264D|CNTNAP4_uc002fex.1_Silent_p.D292D|CNTNAP4_uc002few.2_Silent_p.D264D	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	289	Extracellular (Potential).|Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TCACAGTGGACGAACACAGGC	0.448													4	26					0	0	0	0	T	76482788	T	T	76482788	2	4	197	1	0	0	0	0	0	0	0	1	3664	535	19	1		1	CNTNAP4	16	76482788	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	4764302	76482788	13871965	142	36369											
TM4SF5	9032	broad.mit.edu	37	chr17	4684093	4684093	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttgtcccacaggtactgtgtCcggggattgcagccgttcgg	5	11	14	11	3	0	0	0	0	0	0	3	1	2	1	3	4	3	3	3	4	1	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr17:4684093C>G	uc002fyw.1	+	2	218	c.187C>G	c.(187-189)CCG>GCG	p.P63A		NM_003963	NP_003954	O14894	T4S5_HUMAN	transmembrane 4 superfamily member 5	63	Helical; (Potential).					integral to plasma membrane				ovary(1)	1						GGTACTGTGTCCGGGGATTGC	0.423													7	22					0	0	0	0	G	4684093	G	G	4684093	3	3	197	1	0	0	0	0	1	0	0	0	16037	855	30	2	193	2	TM4SF5	17	4684093	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		4684093	76511117	143	36370											
PSMB6	5694	broad.mit.edu	37	chr17	4700737	4700737	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctgccatcctgcaggtccTacatcgccaatcgagtgact	8	11	8	14	2	1	1	0	1	1	0	5	2	3	1	4	1	3	1	4	1	2	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr17:4700737T>C	uc002fzb.2	+	3	208	c.175T>C	c.(175-177)TAC>CAC	p.Y59H		NM_002798	NP_002789	P28072	PSB6_HUMAN	proteasome beta 6 subunit precursor	59					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2						CTGCAGGTCCTACATCGCCAA	0.547													3	192					0	0	0	0	C	4700737	C	C	4700737	3	2	197	1	0	0	0	0	1	0	0	0	12743	1522	53	5	185	5	PSMB6	17	4700737	Missense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08	16644	4700737	76494473	144	36371											
TOM1L2	146691	broad.mit.edu	37	chr17	17751077	17751077	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagcagctttggctctttCttcaaggaatttatcaaact	10	16	6	9	0	5	0	3	0	2	0	5	1	5	1	0	2	3	3	0	2	4	6			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr17:17751077C>T	uc002grz.3	-	15	1553	c.1396G>A	c.(1396-1398)GAA>AAA	p.E466K	TOM1L2_uc002gry.3_Missense_Mutation_p.E416K|TOM1L2_uc010vwy.1_Missense_Mutation_p.E442K|TOM1L2_uc010cpr.2_Missense_Mutation_p.E421K|TOM1L2_uc010vwz.1_Missense_Mutation_p.E347K|TOM1L2_uc010vxa.1_Missense_Mutation_p.E348K|TOM1L2_uc002grv.3_Missense_Mutation_p.E199K	NM_001082968	NP_001076437	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 isoform 3	466				E -> V (in Ref. 1; AAL78338).	intracellular protein transport	intracellular					0	all_neural(463;0.228)					TTGGCTCTTTCTTCAAGGAAT	0.592													5	74					0	0	0	0	T	17751077	T	T	17751077	3	4	197	1	0	0	0	0	1	0	0	0	16419	922	32	2	131	2	TOM1L2	17	17751077	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	13050340	17751077	63444133	145	36372											
ALDOC	230	broad.mit.edu	37	chr17	26901251	26901251	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagggccttgtacacagcAgccaagacctgggtggggat	9	7	14	11	0	1	1	1	0	0	1	1	2	1	2	3	4	3	2	3	4	2	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr17:26901251A>G	uc002hbp.2	-	7	778	c.633T>C	c.(631-633)GCT>GCC	p.A211A	PIGS_uc002hbn.2_5'Flank|PIGS_uc002hbo.2_5'Flank|PIGS_uc010wap.1_5'Flank|ALDOC_uc010cro.2_Silent_p.A183A	NM_005165	NP_005156	P09972	ALDOC_HUMAN	fructose-bisphosphate aldolase C	211					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			ovary(1)	1	Lung NSC(42;0.00431)					TGTACACAGCAGCCAAGACCT	0.567													18	186					0	0	0	0	G	26901251	G	G	26901251	2	3	197	1	0	0	0	0	0	0	0	1	509	175	7	5		5	ALDOC	17	26901251	Silent	SNP	A	TCGA-CV-6938-01A-11D-1912-08	9150174	26901251	54293959	146	36373											
GRB7	2886	broad.mit.edu	37	chr17	37901747	37901747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgtgtcattgagaaccccCgggaggctctgagtgtggcc	6	8	16	11	2	2	2	1	2	1	1	2	4	2	3	3	4	1	1	3	4	1	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr17:37901747C>T	uc002hsr.2	+	11	1415	c.1165C>T	c.(1165-1167)CGG>TGG	p.R389W	GRB7_uc002hss.2_Missense_Mutation_p.R389W|GRB7_uc010cwc.2_Missense_Mutation_p.R389W|GRB7_uc002hst.2_Missense_Mutation_p.R389W	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	389					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TGAGAACCCCCGGGAGGCTCT	0.612													10	70					0	0	0	0	T	37901747	T	T	37901747	3	4	197	1	0	0	0	0	1	0	0	0	6798	643	23	1	1203	1	GRB7	17	37901747	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	11000496	37901747	43293463	147	36374											
ZPBP2	124626	broad.mit.edu	37	chr17	38027749	38027749	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaatataactgaaactggaCagctgatggtgaaagatttt	16	12	9	4	0	0	4	0	3	0	1	0	5	0	5	0	2	3	1	0	2	6	5			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr17:38027749C>A	uc002hte.2	+	4	430	c.277C>A	c.(277-279)CAG>AAG	p.Q93K	ZPBP2_uc002htf.2_Missense_Mutation_p.Q71K	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	93					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			TGAAACTGGACAGCTGATGGT	0.294													6	60					0.00198382	0.00249079	1	0	A	38027749	A	A	38027749	3	1	197	1	0	0	0	0	1	0	0	0	18287	479	17	4	291	4	ZPBP2	17	38027749	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	126002	38027749	43167461	148	36375											
KRTAP4-8	728224	broad.mit.edu	37	chr17	39254188	39254188	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actggcagcactggggtctgCagcagcaggacacactgtag	10	6	14	11	0	1	0	0	0	1	0	1	1	1	1	0	4	4	6	0	4	1	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr17:39254188C>A	uc010wfo.1	-	1	188	c.149G>T	c.(148-150)TGC>TTC	p.C50F		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	50	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].|6.					keratin filament					0						CTGGGGTCTGCAGCAGCAGGA	0.652													14	61					6.72482e-11	9.10066e-11	1	0	A	39254188	A	A	39254188	3	1	197	1	0	0	0	0	1	0	0	0	8596	710	25	4	412	4	KRTAP4-8	17	39254188	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	1226439	39254188	41941022	149	36376											
TUBG2	27175	broad.mit.edu	37	chr17	40818790	40818790	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcggccacccagccagactAcatttcctggggcacccagg	8	6	11	16	1	0	1	0	0	0	1	1	1	1	1	5	4	3	1	5	4	1	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr17:40818790A>T	uc010wgr.1	+	11	1584	c.1328A>T	c.(1327-1329)TAC>TTC	p.Y443F	TUBG2_uc002iaq.2_3'UTR|TUBG2_uc002iar.2_Missense_Mutation_p.Y290F|TUBG2_uc002ias.2_Missense_Mutation_p.Y285F|TUBG2_uc002iap.2_Missense_Mutation_p.Y290F	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	443					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		CAGCCAGACTACATTTCCTGG	0.542													5	62					0	0	0	0	T	40818790	T	T	40818790	3	4	197	1	0	0	0	0	1	0	0	0	16833	391	14	5	1370	5	TUBG2	17	40818790	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	1564602	40818790	40376420	150	36377											
RPRD1A	55197	broad.mit.edu	37	chr18	33607246	33607246	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaggctgcattttccagatCttgtaatgctctaacgagat	10	14	9	8	1	2	3	0	1	2	2	3	4	3	3	1	1	3	4	1	1	2	5			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr18:33607246C>T	uc002kzf.1	-	5	520	c.514G>A	c.(514-516)GAT>AAT	p.D172N	RPRD1A_uc002kze.1_Missense_Mutation_p.D136N|RPRD1A_uc002kzg.2_Missense_Mutation_p.D172N|RPRD1A_uc010dmw.2_Missense_Mutation_p.D136N|RPRD1A_uc010dmx.2_Missense_Mutation_p.D172N	NM_018170	NP_060640	Q96P16	RPR1A_HUMAN	regulation of nuclear pre-mRNA domain containing	172										ovary(1)|breast(1)	2						TTTTCCAGATCTTGTAATGCT	0.353													10	121					0	0	0	0	T	33607246	T	T	33607246	3	4	197	1	0	0	0	0	1	0	0	0	13680	913	32	2	436	2	RPRD1A	18	33607246	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		33607246	44470002	151	36378											
MUC16	94025	broad.mit.edu	37	chr19	9066795	9066795	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattagtcgctgctgtgcttGtggaaggatgcatggcttct	6	14	13	8	1	1	0	0	0	1	0	2	2	1	2	0	3	3	5	0	3	2	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr19:9066795G>A	uc002mkp.2	-	3	20855	c.20651C>T	c.(20650-20652)ACA>ATA	p.T6884I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6886	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGCTGTGCTTGTGGAAGGATG	0.478													28	217					0	0	0	0	A	9066795	A	A	9066795	3	1	197	1	0	0	0	0	1	0	0	0	10026	1377	48	4	23200	4	MUC16	19	9066795	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08		9066795	50062188	152	36379											
MUC16	94025	broad.mit.edu	37	chr19	9091710	9091711	+	Frame_Shift_Ins	INS	-	G	G																															taggtgacaaggtggctcctINSgtcagtcctgaatccatttc																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr19:9091710_9091711insG	uc002mkp.2	-	1	308_309	c.104_105insC	c.(103-105)ACAfs	p.T35fs		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	35	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTGGCTCCTGTCAGTCCTGA	0.525													---	---	---								G	9091711	G	G	9091710	7	5	197	1	0	1	1	0	0	0	0	0	10026	1567	55	0	43754	0	MUC16	19	9091710	Frame_Shift_Ins	INS	-	TCGA-CV-6938-01A-11D-1912-08	24915	9091710	50037273	153	36380											
MED26	9441	broad.mit.edu	37	chr19	16688252	16688252	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagcctctggaggtcattgCggctcttcaggtcatggatg	6	11	14	10	1	5	0	3	0	2	0	5	2	5	2	1	5	2	2	1	5	0	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr19:16688252C>T	uc002nen.1	-	3	650	c.389G>A	c.(388-390)CGC>CAC	p.R130H	MED26_uc002nee.2_RNA	NM_004831	NP_004822	O95402	MED26_HUMAN	mediator complex subunit 26	130					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			ovary(2)	2						GAGGTCATTGCGGCTCTTCAG	0.746													3	18					0	0	0	0	T	16688252	T	T	16688252	3	4	197	1	0	0	0	0	1	0	0	0	9497	768	27	1	1417	1	MED26	19	16688252	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	7596542	16688252	42440731	154	36381											
MLL4	9757	broad.mit.edu	37	chr19	36215919	36215919	+	Frame_Shift_Del	DEL	T	-	-																															gcccctggcccctttgcttcTtttcccaatggctggactgg																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr19:36215919delT	uc010eei.2	+	11	3459	c.3459delT	c.(3457-3459)TCTfs	p.S1153fs		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1153					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCTTTGCTTCTTTTCCCAATG	0.587													---	---	---								-	36215919	-	-	36215919	7	5	197	1	0	1	0	1	0	0	0	0	9676	1596	56	0	3497	0	MLL4	19	36215919	Frame_Shift_Del	DEL	T	TCGA-CV-6938-01A-11D-1912-08	19527667	36215919	22913064	155	36382											
MLL4	9757	broad.mit.edu	37	chr19	36218428	36218429	+	Frame_Shift_Ins	INS	-	A	A																															agcgcagccccgctggcgagINSaggccctgagcggggccctc																										TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr19:36218428_36218429insA	uc010eei.2	+	17	4207_4208	c.4207_4208insA	c.(4207-4209)GAGfs	p.E1403fs		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1403					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCGCTGGCGAGAGGCCCTGAGC	0.678													---	---	---								A	36218429	A	A	36218428	7	5	197	1	0	1	1	0	0	0	0	0	9676	943	33	0	4269	0	MLL4	19	36218428	Frame_Shift_Ins	INS	-	TCGA-CV-6938-01A-11D-1912-08	2509	36218428	22910555	156	36383											
ZNF607	84775	broad.mit.edu	37	chr19	38190161	38190161	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacaaggtgggaaaactgacGaaaggcctttccacattcct	13	8	9	11	1	0	1	0	1	0	0	2	3	2	2	3	3	1	0	3	3	4	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr19:38190161G>A	uc002ohc.1	-	5	1467	c.871C>T	c.(871-873)CGT>TGT	p.R291C	ZNF607_uc002ohb.1_Missense_Mutation_p.R290C	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	291	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			GAAAACTGACGAAAGGCCTTT	0.428													10	76					0	0	0	0	A	38190161	A	A	38190161	3	1	197	1	0	0	0	0	1	0	0	0	18100	1058	37	1	1223	1	ZNF607	19	38190161	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	1971733	38190161	20938822	157	36384											
CYP2B6	1555	broad.mit.edu	37	chr19	41509997	41509997	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaggccatacgggaggcccTtgtggacaaggctgaggcct	9	6	16	10	1	0	2	0	1	0	1	0	4	0	4	3	6	1	1	3	6	2	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr19:41509997T>C	uc002opr.1	+	2	270	c.263T>C	c.(262-264)CTT>CCT	p.L88P	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.L48P	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	88					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CGGGAGGCCCTTGTGGACAAG	0.602													3	118					0	0	0	0	C	41509997	C	C	41509997	3	2	197	1	0	0	0	0	1	0	0	0	4181	1609	56	5	269	5	CYP2B6	19	41509997	Missense_Mutation	SNP	T	TCGA-CV-6938-01A-11D-1912-08	3319836	41509997	17618986	158	36385											
ZNF835	90485	broad.mit.edu	37	chr19	57175375	57175375	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggacacgtggctgaaggCggccccgcattgcaggcacc	8	4	15	14	4	0	1	0	1	0	0	0	3	0	2	3	5	1	4	3	5	1	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr19:57175375C>T	uc010ygo.1	-	2	1258	c.1258G>A	c.(1258-1260)GCC>ACC	p.A420T	ZNF835_uc010ygn.1_Missense_Mutation_p.A398T	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						TGGCTGAAGGCGGCCCCGCAT	0.657													9	63					0	0	0	0	T	57175375	T	T	57175375	3	4	197	1	0	0	0	0	1	0	0	0	18253	768	27	1	423	1	ZNF835	19	57175375	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	15665378	57175375	1953608	159	36386											
SPTLC3	55304	broad.mit.edu	37	chr20	13140735	13140735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctcgcagaagctcgggctCggttttgtgtttcagcggca	5	11	13	12	4	1	1	1	0	0	1	4	1	1	1	1	3	2	6	1	3	1	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr20:13140735C>T	uc002wod.1	+	11	1790	c.1501C>T	c.(1501-1503)CGG>TGG	p.R501W		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	501					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	AGCTCGGGCTCGGTTTTGTGT	0.507													4	83					0	0	0	0	T	13140735	T	T	13140735	3	4	197	1	0	0	0	0	1	0	0	0	15191	875	31	1	1543	1	SPTLC3	20	13140735	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		13140735	49884785	160	36387											
NANP	140838	broad.mit.edu	37	chr20	25604502	25604502	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggggacgttacctccaacAtgcctctcctgctcgccccg	5	9	10	17	3	1	0	0	0	1	0	4	1	2	1	6	2	4	2	6	2	2	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr20:25604502A>T	uc002wuy.2	-	1	147	c.83T>A	c.(82-84)ATG>AAG	p.M28K	uc002wuz.2_5'Flank	NM_152667	NP_689880	Q8TBE9	NANP_HUMAN	N-acetylneuraminic acid phosphatase	28					N-acetylneuraminate biosynthetic process		N-acylneuraminate-9-phosphatase activity|phosphoglycolate phosphatase activity				0						TACCTCCAACATGCCTCTCCT	0.692													5	45					0	0	0	0	T	25604502	T	T	25604502	3	4	197	1	0	0	0	0	1	0	0	0	10207	217	8	5	671	5	NANP	20	25604502	Missense_Mutation	SNP	A	TCGA-CV-6938-01A-11D-1912-08	12463767	25604502	37421018	161	36388											
C20orf132	140699	broad.mit.edu	37	chr20	35748234	35748234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctcttggccactggactcCggagaagctgaaagaaccca	11	7	11	12	1	1	3	0	1	1	2	3	5	2	4	3	3	2	1	3	3	3	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr20:35748234C>T	uc010zvu.1	-	20	2358	c.2267G>A	c.(2266-2268)CGG>CAG	p.R756Q	C20orf132_uc002xgk.2_Missense_Mutation_p.R378Q	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Myeloproliferative disorder(115;0.00878)				CACTGGACTCCGGAGAAGCTG	0.463													11	100					0	0	0	0	T	35748234	T	T	35748234	3	4	197	1	0	0	0	0	1	0	0	0	2096	652	23	1	919	1	C20orf132	20	35748234	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	10143732	35748234	27277286	162	36389											
SGK2	10110	broad.mit.edu	37	chr20	42213608	42213608	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tctggggcctcaagtgcattCctgggattttcttatgcgcc	5	14	11	11	1	3	0	1	0	2	0	4	1	4	1	3	3	2	1	3	3	2	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr20:42213608C>G	uc002xkv.2	+	12	1455	c.1236C>G	c.(1234-1236)TTC>TTG	p.F412L	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.F352L|SGK2_uc010ggm.2_3'UTR|SGK2_uc002xks.2_Missense_Mutation_p.F351L|SGK2_uc002xku.2_Missense_Mutation_p.F352L	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	412	AGC-kinase C-terminal.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CAAGTGCATTCCTGGGATTTT	0.478													18	134					0	0	0	0	G	42213608	G	G	42213608	3	3	197	1	0	0	0	0	1	0	0	0	14274	854	30	2	1282	2	SGK2	20	42213608	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	6465374	42213608	20811912	163	36390											
PRIC285	85441	broad.mit.edu	37	chr20	62197118	62197118	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggtgctgccgcagcctcCgtctgcgctgtggttgccgt	1	11	15	14	4	1	0	0	0	1	0	2	0	2	0	4	2	5	5	4	2	0	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr20:62197118C>T	uc002yfm.2	-	9	3949	c.3057G>A	c.(3055-3057)ACG>ACA	p.T1019T	PRIC285_uc002yfl.1_Silent_p.T450T	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1019	Ala-rich.				cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CCGCAGCCTCCGTCTGCGCTG	0.687													9	41					0	0	0	0	T	62197118	T	T	62197118	2	4	197	1	0	0	0	0	0	0	0	1	12547	639	23	1		1	PRIC285	20	62197118	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	19983510	62197118	828402	164	36391											
DYRK1A	1859	broad.mit.edu	37	chr21	38877706	38877706	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgactacttgaagttcaaaGacctcattttaaggatgctt	12	14	7	8	0	2	3	2	2	0	1	2	4	2	4	1	1	2	2	1	1	4	6			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr21:38877706G>C	uc002ywk.2	+	9	1435	c.1360G>C	c.(1360-1362)GAC>CAC	p.D454H	DYRK1A_uc002ywi.2_Missense_Mutation_p.D454H|DYRK1A_uc002ywj.2_Missense_Mutation_p.D445H|DYRK1A_uc002ywl.2_Missense_Mutation_p.D454H|DYRK1A_uc002ywm.2_Missense_Mutation_p.D454H|DYRK1A_uc011aei.1_Missense_Mutation_p.D215H	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	454	Protein kinase.				nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4						GAAGTTCAAAGACCTCATTTT	0.453													7	79					0	0	0	0	C	38877706	C	C	38877706	3	2	197	1	0	0	0	0	1	0	0	0	4876	942	33	2	1394	2	DYRK1A	21	38877706	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08		38877706	9252189	165	36392											
POTEH	23784	broad.mit.edu	37	chr22	16287402	16287402	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggctccatgaaagcgctgtCgtcgtagtctccccaagggc	7	8	12	14	4	1	1	0	1	1	0	5	1	2	1	3	2	1	3	3	2	3	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr22:16287402C>T	uc010gqp.2	-	1	536	c.484G>A	c.(484-486)GAC>AAC	p.D162N	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_5'UTR|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	162										skin(1)	1						AAAGCGCTGTCGTCGTAGTCT	0.587													20	185					0	0	0	0	T	16287402	T	T	16287402	3	4	197	1	0	0	0	0	1	0	0	0	12322	884	31	1	1193	1	POTEH	22	16287402	Missense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08		16287402	35017164	166	36393											
ZDHHC8	29801	broad.mit.edu	37	chr22	20127072	20127072	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtggatgtgcgaggtatcCaggtccgcatgaagtggtgt	8	10	16	7	3	0	1	0	1	0	0	2	3	2	2	2	4	1	2	2	4	2	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr22:20127072C>T	uc002zrq.2	+	3	404	c.298C>T	c.(298-300)CAG>TAG	p.Q100*	ZDHHC8_uc002zrr.1_Nonsense_Mutation_p.Q100*|ZDHHC8_uc010gsa.2_5'UTR	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	100	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					GCGAGGTATCCAGGTCCGCAT	0.617													4	79					0	0	0	0	T	20127072	T	T	20127072	4	4	197	1	0	0	0	0	0	1	0	0	17688	595	21	4	308	4	ZDHHC8	22	20127072	Nonsense_Mutation	SNP	C	TCGA-CV-6938-01A-11D-1912-08	3839670	20127072	31177494	167	36394											
SUSD2	56241	broad.mit.edu	37	chr22	24583660	24583660	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccccagtgagaccaccctCaaccccagcctggcacaaga	11	5	7	18	0	1	2	1	1	0	2	2	3	2	2	7	1	2	1	7	1	2	1			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr22:24583660C>G	uc002zzn.1	+	12	2057	c.2013C>G	c.(2011-2013)CTC>CTG	p.L671L		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	671	Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						AGACCACCCTCAACCCCAGCC	0.592													9	78					0	0	0	0	G	24583660	G	G	24583660	2	3	197	1	0	0	0	0	0	0	0	1	15474	813	29	2		2	SUSD2	22	24583660	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	4456588	24583660	26720906	168	36395											
SNRPD3	6634	broad.mit.edu	37	chr22	24953663	24953663	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgtctattggtgtgccgatTaaagtactgcatgaggccga	10	12	12	7	2	1	1	0	1	1	0	1	3	1	1	2	2	3	2	2	2	4	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr22:24953663T>A	uc003aam.1	+	2	461	c.21T>A	c.(19-21)ATT>ATA	p.I7I	C22orf13_uc003aah.2_5'Flank|C22orf13_uc003aal.2_5'Flank|C22orf13_uc003aai.3_5'Flank|C22orf13_uc003aaj.3_5'Flank|C22orf13_uc003aak.3_5'Flank|SNRPD3_uc011aju.1_Silent_p.I7I	NM_004175	NP_004166	P62318	SMD3_HUMAN	small nuclear ribonucleoprotein polypeptide D3	7					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	enzyme binding|histone pre-mRNA DCP binding			ovary(1)	1						GTGTGCCGATTAAAGTACTGC	0.478													13	93					0	0	0	0	A	24953663	A	A	24953663	2	1	197	1	0	0	0	0	0	0	0	1	14930	1742	61	5		5	SNRPD3	22	24953663	Silent	SNP	T	TCGA-CV-6938-01A-11D-1912-08	370003	24953663	26350903	169	36396											
EP300	2033	broad.mit.edu	37	chr22	41547861	41547861	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccagccagctgtaagcattGaaggacaggtatcaaatcct	13	8	9	11	0	1	1	1	1	0	0	2	2	2	2	3	2	3	4	3	2	4	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chr22:41547861G>A	uc003azl.3	+	15	3237	c.2842G>A	c.(2842-2844)GAA>AAA	p.E948K		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	948					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGTAAGCATTGAAGGACAGGT	0.478			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				20	121					0	0	0	0	A	41547861	A	A	41547861	3	1	197	1	0	0	0	0	1	0	0	0	5172	1291	45	2	2900	2	EP300	22	41547861	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	16594198	41547861	9756705	170	36397											
KLHL13	90293	broad.mit.edu	37	chrX	117043397	117043397	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatcgaggatcaaatctgaaGactgtatcaactgccgtttt	12	13	8	8	2	3	2	2	1	1	1	4	4	3	3	1	1	2	2	1	1	5	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chrX:117043397G>C	uc004eql.2	-	5	1295	c.1233C>G	c.(1231-1233)GTC>GTG	p.V411V	KLHL13_uc004eqk.2_Silent_p.V360V|KLHL13_uc011mtn.1_Silent_p.V251V|KLHL13_uc011mto.1_Silent_p.V405V|KLHL13_uc011mtp.1_Silent_p.V413V|KLHL13_uc004eqm.2_Silent_p.V360V|KLHL13_uc011mtq.1_Silent_p.V395V	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	411	Kelch 2.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						CAAATCTGAAGACTGTATCAA	0.413													10	44					0	0	0	0	C	117043397	C	C	117043397	2	2	197	1	0	0	0	0	0	0	0	1	8408	929	33	2		2	KLHL13	23	117043397	Silent	SNP	G	TCGA-CV-6938-01A-11D-1912-08		117043397	38227163	171	36398											
LAMP2	3920	broad.mit.edu	37	chrX	119565263	119565263	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taagtactcctgccaaggcaGctcccaccgctatgggcaca	10	7	9	15	1	0	0	0	0	0	0	2	0	2	0	4	2	3	5	4	2	4	3			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chrX:119565263G>A	uc004est.3	-	9	1328	c.1148C>T	c.(1147-1149)GCT>GTT	p.A383V	LAMP2_uc004ess.3_Intron|LAMP2_uc011mtz.1_Intron	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	383	Helical; (Potential).				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						TGCCAAGGCAGCTCCCACCGC	0.448													28	98					0	0	0	0	A	119565263	A	A	119565263	3	1	197	1	0	0	0	0	1	0	0	0	8658	971	34	4	235	4	LAMP2	23	119565263	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	2521866	119565263	35705297	172	36399											
CDR1	1038	broad.mit.edu	37	chrX	139866350	139866350	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggtcttccaggaaatccGtgtcttccagcaaatccacg	10	9	8	14	2	2	0	0	0	2	0	6	1	6	1	5	2	1	1	5	2	2	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chrX:139866350G>A	uc004fbg.1	-	1	374	c.182C>T	c.(181-183)ACG>ATG	p.T61M	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	61	10.|23 X 6 AA approximate repeats.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CAGGAAATCCGTGTCTTCCAG	0.438													32	89					0	0	0	0	A	139866350	A	A	139866350	3	1	197	1	0	0	0	0	1	0	0	0	3186	1145	40	1	610	1	CDR1	23	139866350	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	20301087	139866350	15404210	173	36400											
SLITRK4	139065	broad.mit.edu	37	chrX	142718785	142718785	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgatttggtctgtagactGaaaccttctcacagttgaca	10	13	9	9	0	2	4	1	3	2	1	3	4	2	4	1	1	1	3	1	1	2	4			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chrX:142718785G>A	uc004fbx.2	-	2	516	c.140C>T	c.(139-141)TCA>TTA	p.S47L	SLITRK4_uc004fby.2_Missense_Mutation_p.S47L	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	47	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TCTGTAGACTGAAACCTTCTC	0.363													10	27					0	0	0	0	A	142718785	A	A	142718785	3	1	197	1	0	0	0	0	1	0	0	0	14809	1294	45	2	2377	2	SLITRK4	23	142718785	Missense_Mutation	SNP	G	TCGA-CV-6938-01A-11D-1912-08	2852435	142718785	12551775	174	36401											
PLXNA3	55558	broad.mit.edu	37	chrX	153689702	153689702	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcggctgctcctggcgcggCgtggagtaccgcttggtgca	4	9	16	12	5	0	0	0	0	0	0	2	1	1	1	2	5	3	5	2	5	1	2			TCGA-CV-6938-01A-11D-1912-08	TCGA-CV-6938-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1dcb76e-b98f-4989-90a2-885e50d8174c	55a7e73b-bbe2-4508-8067-036b3a5d5ad6	g.chrX:153689702C>T	uc004flm.2	+	3	1031	c.858C>T	c.(856-858)GGC>GGT	p.G286G		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	286	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTGGCGCGGCGTGGAGTACC	0.637													22	52					0	0	0	0	T	153689702	T	T	153689702	2	4	197	1	0	0	0	0	0	0	0	1	12176	755	27	1		1	PLXNA3	23	153689702	Silent	SNP	C	TCGA-CV-6938-01A-11D-1912-08	10970917	153689702	1580858	175	36402											
CDK11B	984	broad.mit.edu	37	chr1	1650883	1650885	+	In_Frame_Del	DEL	TCT	-	-																															gtttgatggccaaagaatcaTcttcttctcctctgaaataa																								rs147453611	by1000genomes	TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:1650883_1650885delTCT	uc001agv.1	-	6	348_350	c.237_239delAGA	c.(235-240)GAAGAT>GAT	p.E79del	CDK11B_uc001ags.1_5'Flank|CDK11B_uc001agt.1_5'Flank|CDK11B_uc001aha.1_In_Frame_Del_p.E45del|CDK11B_uc001agw.1_In_Frame_Del_p.E45del|CDK11B_uc001agy.1_In_Frame_Del_p.E79del|CDK11B_uc001agx.1_In_Frame_Del_p.E79del|CDK11B_uc001agz.1_Translation_Start_Site|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc009vkr.2_In_Frame_Del_p.E79del|CDK11A_uc009vks.2_In_Frame_Del_p.E79del|CDK11A_uc010nys.1_In_Frame_Del_p.E79del|CDK11A_uc010nyt.1_In_Frame_Del_p.E79del|CDK11A_uc010nyu.1_RNA|CDK11A_uc009vkt.1_In_Frame_Del_p.E79del|CDK11A_uc009vku.1_In_Frame_Del_p.E79del|CDK11A_uc009vkv.1_In_Frame_Del_p.E79del|CDK11A_uc001aht.1_In_Frame_Del_p.E79del|CDK11B_uc001ahu.1_In_Frame_Del_p.E79del|CDK11B_uc001ahv.1_In_Frame_Del_p.E79del|CDK11B_uc001ahw.1_In_Frame_Del_p.E79del	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	79					apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CAAAGAATCATCTTCTTCTCCTC	0.394													---	---	---								-	1650885	-	-	1650883	7	5	198	1	0	1	0	1	0	0	0	0	3142	1435	50	0	2198	0	CDK11B	1	1650883	In_Frame_Del	DEL	TCT	TCGA-CV-6939-01A-11D-1912-08		1650883	247599738	1	36403											
CASZ1	54897	broad.mit.edu	37	chr1	10725438	10725438	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccgggctgccccagactcAgggccactgcgctcttggtc	4	7	13	17	2	2	1	1	0	1	1	3	1	2	1	4	3	2	2	4	3	0	1			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:10725438A>T	uc001aro.2	-	5	527	c.207T>A	c.(205-207)CCT>CCA	p.P69P	CASZ1_uc001arp.1_Silent_p.P69P|CASZ1_uc009vmx.2_Silent_p.P93P	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	69					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CCCCAGACTCAGGGCCACTGC	0.697													16	62					0	0	0	0	T	10725438	T	T	10725438	2	4	198	1	0	0	0	0	0	0	0	1	2697	175	7	5		5	CASZ1	1	10725438	Silent	SNP	A	TCGA-CV-6939-01A-11D-1912-08	9074555	10725438	238525183	2	36404											
ID3	3399	broad.mit.edu	37	chr1	23885665	23885665	+	Frame_Shift_Del	DEL	C	-	-																															gggtccaggggctggctcggCcaggactacctgcaggtcga																										TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:23885665delC	uc001bhh.3	-	1	658	c.253delG	c.(253-255)GCCfs	p.A85fs	ID3_uc001bhg.1_Frame_Shift_Del_p.A85fs	NM_002167	NP_002158	Q02535	ID3_HUMAN	inhibitor of DNA binding 3	85					negative regulation of sequence-specific DNA binding transcription factor activity		transcription corepressor activity			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00314)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;8.83e-25)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;6.5e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		GCTGGCTCGGCCAGGACTACC	0.632													---	---	---								-	23885665	-	-	23885665	7	5	198	1	0	1	0	1	0	0	0	0	7530	739	26	0	114	0	ID3	1	23885665	Frame_Shift_Del	DEL	C	TCGA-CV-6939-01A-11D-1912-08	13160227	23885665	225364956	3	36405											
PIK3R3	8503	broad.mit.edu	37	chr1	46543232	46543232	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcatttttgttgaggcatctCggaccaagaaggtcccatct	9	12	10	10	1	2	2	0	1	2	1	4	3	3	3	2	3	0	3	2	3	2	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:46543232C>T	uc001cpb.3	-	3	1025	c.269G>A	c.(268-270)CGA>CAA	p.R90Q	PIK3R3_uc009vyb.2_Missense_Mutation_p.R90Q|PIK3R3_uc009vyc.2_Missense_Mutation_p.R107Q|PIK3R3_uc001cpc.3_Missense_Mutation_p.R90Q|PIK3R3_uc010olw.1_Missense_Mutation_p.R136Q	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	90	SH2 1.				insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					TGAGGCATCTCGGACCAAGAA	0.393													25	97					0	0	0	0	T	46543232	T	T	46543232	3	4	198	1	0	0	0	0	1	0	0	0	11975	884	31	1	1148	1	PIK3R3	1	46543232	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08	22657567	46543232	202707389	4	36406											
CYP4A11	1579	broad.mit.edu	37	chr1	47399867	47399867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggtgatggaggctccatCacccaggaggctgtggatct	8	8	14	11	0	2	1	1	1	1	0	3	4	3	4	3	6	0	2	3	6	0	0			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:47399867C>T	uc001cqp.3	-	8	1120	c.1069G>A	c.(1069-1071)GAT>AAT	p.D357N	CYP4A11_uc001cqq.2_Missense_Mutation_p.D357N|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	357					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GAGGCTCCATCACCCAGGAGG	0.622													14	31					0	0	0	0	T	47399867	T	T	47399867	3	4	198	1	0	0	0	0	1	0	0	0	4200	826	29	2	510	2	CYP4A11	1	47399867	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08	856635	47399867	201850754	5	36407											
C1orf175	374977	broad.mit.edu	37	chr1	55139731	55139731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggcttctgctggggagaCtcatccttcacattggggat	6	12	14	9	0	3	1	2	0	1	1	4	3	4	2	1	6	1	2	1	6	0	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:55139731C>T	uc010ooe.1	+	10	2167	c.1843C>T	c.(1843-1845)CTC>TTC	p.L615F	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.L183F|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.L133F|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.L615F|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	615						integral to membrane	binding				0						GCTGGGGAGACTCATCCTTCA	0.488													23	86					0	0	0	0	T	55139731	T	T	55139731	3	4	198	1	0	0	0	0	1	0	0	0	2025	565	20	4	1873	4	C1orf175	1	55139731	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08	7739864	55139731	194110890	6	36408											
DPH5	51611	broad.mit.edu	37	chr1	101490909	101490909	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactgaggtgtaggcttccaGatacactcgactgcagcgtc	9	9	12	11	2	0	2	0	1	0	1	3	4	1	2	1	2	3	3	1	2	2	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:101490909G>A	uc001dts.2	-	2	238	c.91C>T	c.(91-93)CTG>TTG	p.L31L	DPH5_uc001dtr.2_Silent_p.L31L|DPH5_uc001dtq.2_RNA|DPH5_uc001dtt.2_Silent_p.L31L|DPH5_uc001dtu.2_RNA|DPH5_uc001dtv.2_RNA|DPH5_uc001dtw.2_RNA|DPH5_uc001dtx.2_Silent_p.L31L|DPH5_uc001dty.2_5'UTR|DPH5_uc001dtz.2_RNA|uc001dua.2_5'Flank|uc001dub.2_5'Flank	NM_015958	NP_057042	Q9H2P9	DPH5_HUMAN	diphthine synthase isoform a	31					peptidyl-diphthamide biosynthetic process from peptidyl-histidine		diphthine synthase activity				0		all_epithelial(167;3.1e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0385)|all cancers(265;0.043)|COAD - Colon adenocarcinoma(174;0.151)|Colorectal(144;0.173)|Lung(183;0.198)		TAGGCTTCCAGATACACTCGA	0.507													4	52					0	0	0	0	A	101490909	A	A	101490909	2	1	198	1	0	0	0	0	0	0	0	1	4745	933	33	2		2	DPH5	1	101490909	Silent	SNP	G	TCGA-CV-6939-01A-11D-1912-08	46351178	101490909	147759712	7	36409											
TXNIP	10628	broad.mit.edu	37	chr1	145438932	145438932	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagttactcgtgtcaaagccGttaggatcctggcttgcgga	9	11	12	9	3	1	0	1	0	0	0	3	2	2	2	2	3	3	3	2	3	4	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:145438932G>A	uc001enn.3	+	1	471	c.130G>A	c.(130-132)GTT>ATT	p.V44I	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_5'Flank	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	44					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGTCAAAGCCGTTAGGATCCT	0.542													24	58					0	0	0	0	A	145438932	A	A	145438932	3	1	198	1	0	0	0	0	1	0	0	0	16871	1145	40	1	132	1	TXNIP	1	145438932	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08	43948023	145438932	103811689	8	36410											
LAMC2	3918	broad.mit.edu	37	chr1	183195980	183195980	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggctacaagagagattcagCgagactggggccttttggca	10	9	14	8	1	1	3	1	0	0	3	1	5	1	3	1	4	2	2	1	4	2	4			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:183195980C>G	uc001gqa.2	+	9	1528	c.1214C>G	c.(1213-1215)GCG>GGG	p.A405G	LAMC2_uc001gpz.3_Missense_Mutation_p.A405G|LAMC2_uc010poa.1_Missense_Mutation_p.A105G	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	405	Laminin EGF-like 4; second part.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						AGAGATTCAGCGAGACTGGGG	0.542													16	250					0	0	0	0	G	183195980	G	G	183195980	3	3	198	1	0	0	0	0	1	0	0	0	8655	768	27	3	1248	3	LAMC2	1	183195980	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08	37757048	183195980	66054641	9	36411											
RGS2	5997	broad.mit.edu	37	chr1	192778228	192778228	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgctatgttcttggctgtTcaacacgactgcagacccat	9	12	9	11	1	2	1	1	0	1	1	2	2	2	1	1	1	3	5	1	1	2	4			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:192778228T>C	uc001gsl.2	+	1	60	c.27T>C	c.(25-27)GTT>GTC	p.V9V		NM_002923	NP_002914	P41220	RGS2_HUMAN	regulator of G-protein signaling 2	9					cell cycle|negative regulation of cardiac muscle hypertrophy|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of MAP kinase activity|negative regulation of phospholipase activity|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|regulation of translation|relaxation of cardiac muscle	cytosol|internal side of plasma membrane|mitochondrion|nucleolus	calmodulin binding|GTPase activator activity|signal transducer activity				0						TCTTGGCTGTTCAACACGACT	0.562													3	101					0	0	0	0	C	192778228	C	C	192778228	2	2	198	1	0	0	0	0	0	0	0	1	13367	1770	62	5		5	RGS2	1	192778228	Silent	SNP	T	TCGA-CV-6939-01A-11D-1912-08	9582248	192778228	56472393	10	36412											
MTR	4548	broad.mit.edu	37	chr1	237037074	237037075	+	Missense_Mutation	DNP	GT	AA	AA																															tctcatttctgtgcctcagaGttattgatttaggagtcatg																										TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:237037074_237037075GT>AA	uc001hyi.3	+	23	2830_2831	c.2407_2408GT>AA	c.(2407-2409)GTT>AAT	p.V803N	MTR_uc010pxw.1_Missense_Mutation_p.V396N|MTR_uc010pxx.1_Missense_Mutation_p.V752N|MTR_uc010pxy.1_Missense_Mutation_p.V657N	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	803	B12-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GTGCCTCAGAGTTATTGATTTA	0.351													6	35					0	0	0	0	AA	237037075	AA	AA	237037074	3	1	198	1	0	0	0	0	1	0	0	0	10011	1043	36	4	2497	4	MTR	1	237037074	Missense_Mutation	DNP	GT	TCGA-CV-6939-01A-11D-1912-08	44258846	237037074	12213547	11	36413											
OR2L2	26246	broad.mit.edu	37	chr1	248201982	248201982	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccatccgtataagcaaaaGagtgtgtgtgatgatgataa	14	11	10	6	1	0	4	0	3	0	1	2	4	2	4	2	0	1	2	2	0	5	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr1:248201982G>C	uc001idw.2	+	1	509	c.413G>C	c.(412-414)AGA>ACA	p.R138T	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ATAAGCAAAAGAGTGTGTGTG	0.438													5	143					0	0	0	0	C	248201982	C	C	248201982	3	2	198	1	0	0	0	0	1	0	0	0	11061	942	33	2	415	2	OR2L2	1	248201982	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08	11164908	248201982	1048639	12	36414											
SH3RF3	344558	broad.mit.edu	37	chr2	110053585	110053585	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaacggccagccaagcccGgagcaccatttcaacaggta	12	4	10	15	2	1	0	1	0	0	0	1	1	1	1	5	3	5	2	5	3	4	2			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr2:110053585G>C	uc010ywt.1	+	7	1811	c.1811G>C	c.(1810-1812)CGG>CCG	p.R604P		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	604							zinc ion binding			ovary(1)	1						AGCCAAGCCCGGAGCACCATT	0.642													7	18					0	0	0	0	C	110053585	C	C	110053585	3	2	198	1	0	0	0	0	1	0	0	0	14325	1116	39	3	1837	3	SH3RF3	2	110053585	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08		110053585	133145788	13	36415											
LRP2	4036	broad.mit.edu	37	chr2	170099522	170099522	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacaccatcacaacgatttGtgacgccaatacatttatcc	15	10	4	12	2	1	1	1	1	0	0	2	2	2	1	3	0	3	0	3	0	5	4			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr2:170099522G>A	uc002ues.2	-	24	3824	c.3611C>T	c.(3610-3612)ACA>ATA	p.T1204I	LRP2_uc010zdf.1_Missense_Mutation_p.T1067I	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1204	LDL-receptor class A 12.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACAACGATTTGTGACGCCAAT	0.403													36	74					0	0	0	0	A	170099522	A	A	170099522	3	1	198	1	0	0	0	0	1	0	0	0	9006	1377	48	4	10580	4	LRP2	2	170099522	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08	60045937	170099522	73099851	14	36416											
PIK3R4	30849	broad.mit.edu	37	chr3	130452855	130452855	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aacgtttccttggcaaactgGgccatgtagggctgaagaaa	12	9	12	8	1	0	2	0	1	0	1	1	2	1	2	2	3	2	4	2	3	5	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr3:130452855G>C	uc003enj.2	-	4	1568	c.987C>G	c.(985-987)GCC>GCG	p.A329A		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	329					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TGGCAAACTGGGCCATGTAGG	0.428													25	127					0	0	0	0	C	130452855	C	C	130452855	2	2	198	1	0	0	0	0	0	0	0	1	11976	1219	43	4		4	PIK3R4	3	130452855	Silent	SNP	G	TCGA-CV-6939-01A-11D-1912-08		130452855	67569575	15	36417											
SLC9A9	285195	broad.mit.edu	37	chr3	142985669	142985669	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctttctggtccagacctaGccttgcaggaggactgcagg	8	9	13	11	0	1	1	0	0	1	1	2	3	2	3	3	4	4	3	3	4	1	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr3:142985669G>A	uc003evn.2	-	16	1995	c.1813C>T	c.(1813-1815)CTA>TTA	p.L605L		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	605					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						TCCAGACCTAGCCTTGCAGGA	0.507													34	80					0	0	0	0	A	142985669	A	A	142985669	2	1	198	1	0	0	0	0	0	0	0	1	14785	962	34	4		4	SLC9A9	3	142985669	Silent	SNP	G	TCGA-CV-6939-01A-11D-1912-08	12532814	142985669	55036761	16	36418											
CC2D2A	57545	broad.mit.edu	37	chr4	15556747	15556747	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggcacatcaggactgacaGacatgaaaaaattggccaag	16	7	10	8	0	1	3	1	2	0	1	1	4	1	4	1	3	0	1	1	3	4	2			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr4:15556747G>A	uc010idv.2	+	21	2784	c.2539G>A	c.(2539-2541)GAC>AAC	p.D847N	CC2D2A_uc003gnx.2_Missense_Mutation_p.D798N|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	847					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						AGGACTGACAGACATGAAAAA	0.468													12	24					0	0	0	0	A	15556747	A	A	15556747	3	1	198	1	0	0	0	0	1	0	0	0	2740	942	33	2	2816	2	CC2D2A	4	15556747	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08		15556747	175597529	17	36419											
AFF1	4299	broad.mit.edu	37	chr4	88029324	88029324	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgcagtgctccacagtccCttccagaaccagtggcatca	9	10	8	14	0	1	1	1	0	0	1	4	1	4	1	4	1	3	3	4	1	1	2			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr4:88029324C>G	uc003hqj.3	+	10	1776	c.1369C>G	c.(1369-1371)CTT>GTT	p.L457V	AFF1_uc011ccz.1_Missense_Mutation_p.L464V|AFF1_uc003hqk.3_Missense_Mutation_p.L457V|AFF1_uc011cda.1_Missense_Mutation_p.L95V	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	457						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TCCACAGTCCCTTCCAGAACC	0.478													9	78					0	0	0	0	G	88029324	G	G	88029324	3	3	198	1	0	0	0	0	1	0	0	0	356	681	24	4	1449	4	AFF1	4	88029324	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08	72472577	88029324	103124952	18	36420											
TBCK	93627	broad.mit.edu	37	chr4	107092375	107092382	+	Frame_Shift_Del	DEL	AGTCCAAC	-	-																															ctgtaagtagcacttttaggAgtccaacaaaacaggttgat																										TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr4:107092375_107092382delAGTCCAAC	uc010ilv.2	-	23	2470_2477	c.2105_2112delGTTGGACT	c.(2104-2112)TGTTGGACTfs	p.C702fs	TBCK_uc003hyb.2_Frame_Shift_Del_p.C445fs|TBCK_uc003hye.2_Frame_Shift_Del_p.C663fs|TBCK_uc003hyc.2_Frame_Shift_Del_p.C639fs|TBCK_uc003hyd.2_Frame_Shift_Del_p.C530fs|TBCK_uc003hyf.2_Frame_Shift_Del_p.C702fs	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	702_704						intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						CACTTTTAGGAGTCCAACAAAACAGGTT	0.389													---	---	---								-	107092382	-	-	107092375	7	5	198	1	0	1	0	1	0	0	0	0	15702	291	11	0	585	0	TBCK	4	107092375	Frame_Shift_Del	DEL	AGTCCAAC	TCGA-CV-6939-01A-11D-1912-08	19063051	107092375	84061901	19	36421											
GEMIN5	25929	broad.mit.edu	37	chr5	154296703	154296703	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgttggatagtacagatCagtttcaggttgggaatctg	9	14	13	5	0	3	1	2	0	1	1	3	3	3	3	0	3	2	5	0	3	3	5			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr5:154296703C>T	uc003lvx.3	-	13	1793	c.1710G>A	c.(1708-1710)CTG>CTA	p.L570L	GEMIN5_uc011ddk.1_Silent_p.L569L	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	570	WD 10.				ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TAGTACAGATCAGTTTCAGGT	0.393													12	142					0	0	0	0	T	154296703	T	T	154296703	2	4	198	1	0	0	0	0	0	0	0	1	6368	813	29	2		2	GEMIN5	5	154296703	Silent	SNP	C	TCGA-CV-6939-01A-11D-1912-08		154296703	26618557	20	36422											
HECW1	23072	broad.mit.edu	37	chr7	43484116	43484116	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcccaggtgcaaaaggacAtccagcctgcccccagtgca	10	5	11	15	0	0	0	0	0	0	0	1	1	1	1	5	3	4	2	5	3	2	0			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr7:43484116A>C	uc003tid.1	+	11	1950	c.1345A>C	c.(1345-1347)ATC>CTC	p.I449L	HECW1_uc011kbi.1_Missense_Mutation_p.I449L	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	449					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GCAAAAGGACATCCAGCCTGC	0.642													3	20					0	0	0	0	C	43484116	C	C	43484116	3	2	198	1	0	0	0	0	1	0	0	0	7081	217	8	5	1379	5	HECW1	7	43484116	Missense_Mutation	SNP	A	TCGA-CV-6939-01A-11D-1912-08		43484116	115654547	21	36423											
ESYT2	57488	broad.mit.edu	37	chr7	158528232	158528232	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctttggacaggaagccgcCactgttcttcacggcaacgt	8	10	11	12	3	3	0	1	0	2	0	3	2	3	2	2	3	2	2	2	3	2	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr7:158528232C>G	uc003wob.1	-	20	2614	c.2548G>C	c.(2548-2550)GGC>CGC	p.G850R	ESYT2_uc003wny.1_RNA|ESYT2_uc003wnz.1_Missense_Mutation_p.G289R|ESYT2_uc003woa.1_Missense_Mutation_p.G427R	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	878	C2 3.					integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						AGGAAGCCGCCACTGTTCTTC	0.458													4	148					0	0	0	0	G	158528232	G	G	158528232	3	3	198	1	0	0	0	0	1	0	0	0	5289	594	21	4	145	4	ESYT2	7	158528232	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08	115044116	158528232	610431	22	36424											
TERF1	7013	broad.mit.edu	37	chr8	73921394	73921394	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctttgccgagctttccgCgacggccgctccgaggactt	4	11	11	15	6	1	0	0	0	1	0	4	4	3	1	4	2	2	2	4	2	0	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr8:73921394C>T	uc003xzd.2	+	1	298	c.273C>T	c.(271-273)CGC>CGT	p.R91R	TERF1_uc003xzc.2_RNA|TERF1_uc003xze.2_Silent_p.R91R	NM_017489	NP_059523	P54274	TERF1_HUMAN	telomeric repeat binding factor 1 isoform 1	91	TRFH dimerization.				age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			ovary(1)|lung(1)|skin(1)	3	Breast(64;0.218)		Epithelial(68;0.0984)			GAGCTTTCCGCGACGGCCGCT	0.667													13	39					0	0	0	0	T	73921394	T	T	73921394	2	4	198	1	0	0	0	0	0	0	0	1	15827	755	27	1		1	TERF1	8	73921394	Silent	SNP	C	TCGA-CV-6939-01A-11D-1912-08		73921394	72442628	23	36425											
TAF1L	138474	broad.mit.edu	37	chr9	32631389	32631389	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtcaccatagggtctgtgcGgcgtcggtggatggacttat	6	11	15	9	4	2	0	1	0	1	0	3	2	2	2	1	5	1	0	1	5	2	2			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr9:32631389G>A	uc003zrg.1	-	1	4279	c.4189C>T	c.(4189-4191)CGC>TGC	p.R1397C	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1397					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGGTCTGTGCGGCGTCGGTGG	0.468													52	231					0	0	0	0	A	32631389	A	A	32631389	3	1	198	1	0	0	0	0	1	0	0	0	15589	1116	39	1	1295	1	TAF1L	9	32631389	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08		32631389	108582042	24	36426											
POMT1	10585	broad.mit.edu	37	chr9	134386815	134386815	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtctttgggaaacctgtgcCctgctggcttcattcccacc	5	12	9	15	1	2	0	1	0	1	0	3	1	3	1	4	2	3	2	4	2	1	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr9:134386815C>G	uc004cav.2	+	10	1215	c.1013C>G	c.(1012-1014)CCC>CGC	p.P338R	POMT1_uc004cax.2_Missense_Mutation_p.P316R|POMT1_uc011mcj.1_Missense_Mutation_p.P94R|POMT1_uc004cau.2_Missense_Mutation_p.P316R|POMT1_uc004caw.2_Missense_Mutation_p.P262R|POMT1_uc011mck.1_Missense_Mutation_p.P199R|POMT1_uc011mcl.1_Missense_Mutation_p.P164R|POMT1_uc011mcm.1_Missense_Mutation_p.P286R|POMT1_uc011mcn.1_Missense_Mutation_p.P41R	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	338	MIR 1.				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		AAACCTGTGCCCTGCTGGCTT	0.498													28	92					0	0	0	0	G	134386815	G	G	134386815	3	3	198	1	0	0	0	0	1	0	0	0	12300	623	22	4	1047	4	POMT1	9	134386815	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08	101755426	134386815	6826616	25	36427											
FCN1	2219	broad.mit.edu	37	chr9	137801845	137801845	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaactcacatcattgtcttgGtctttggtggagaagaagtt	10	14	11	6	0	4	2	2	0	2	2	4	4	4	2	0	3	1	1	0	3	3	4			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr9:137801845G>A	uc004cfi.2	-	9	872	c.780C>T	c.(778-780)GAC>GAT	p.D260D		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	260	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CATTGTCTTGGTCTTTGGTGG	0.483													57	260					0	0	0	0	A	137801845	A	A	137801845	2	1	198	1	0	0	0	0	0	0	0	1	5823	1252	44	4		4	FCN1	9	137801845	Silent	SNP	G	TCGA-CV-6939-01A-11D-1912-08	3415030	137801845	3411586	26	36428											
GFRA1	2674	broad.mit.edu	37	chr10	117884861	117884861	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcgatgtcccggcaggagCagaagagcattccgtagctg	10	6	15	10	3	0	2	0	0	0	2	2	4	2	3	2	3	3	5	2	3	2	2			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr10:117884861C>T	uc001lcj.2	-	6	1339	c.641G>A	c.(640-642)TGC>TAC	p.C214Y	GFRA1_uc001lci.2_Missense_Mutation_p.C209Y|GFRA1_uc009xyr.2_Missense_Mutation_p.C209Y	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	214	2.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		CCGGCAGGAGCAGAAGAGCAT	0.587													9	43					0	0	0	0	T	117884861	T	T	117884861	3	4	198	1	0	0	0	0	1	0	0	0	6384	710	25	4	780	4	GFRA1	10	117884861	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08		117884861	17649886	27	36429											
PAOX	196743	broad.mit.edu	37	chr10	135195045	135195045	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagaagcctgtgaagaccatCcactggaacgggtccttcca	11	7	11	12	1	0	3	0	1	0	2	3	5	3	4	5	2	2	0	5	2	3	1			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr10:135195045C>A	uc001lmv.2	+	3	830	c.750C>A	c.(748-750)ATC>ATA	p.I250I	PAOX_uc001lmw.2_RNA|PAOX_uc001lmx.2_Silent_p.I250I|PAOX_uc001lmy.2_Silent_p.I250I|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_RNA|PAOX_uc001lnc.2_RNA	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	388					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		TGAAGACCATCCACTGGAACG	0.572													10	53					2.17888e-05	3.37109e-05	1	0	A	135195045	A	A	135195045	2	1	198	1	0	0	0	0	0	0	0	1	11477	845	30	2		2	PAOX	10	135195045	Silent	SNP	C	TCGA-CV-6939-01A-11D-1912-08	17310184	135195045	339702	28	36430											
ODF3	113746	broad.mit.edu	37	chr11	196008	196009	+	5'Flank	INS	-	A	A																															tgagcggacctggtgaggggINSacatgggggggaccttggtg																								rs111606709		TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	1f3cdec6-b587-4045-b1af-0d8d2b26ca44	g.chr11:196008_196009insA	uc001lob.2	+						ODF3_uc010qvk.1_5'Flank|ODF3_uc001loc.2_5'Flank	NM_053280	NP_444510	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm				ovary(1)	1		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTGGTGAGGGGACATGGGGGGG	0.673													---	---	---								A	196009	A	A	196008	6	5	198	0	1	1	1	0	0	0	0	0	10883	1189	41	0		0	ODF3	11	196008	5'Flank	INS	-	TCGA-CV-6939-01A-11D-1912-08		196008	134810508	29	36431											
NPAS4	266743	broad.mit.edu	37	chr11	66191328	66191328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatggaagcctggagcctcCgccagcagttgaactctgaa	11	7	11	12	1	1	2	0	2	1	0	2	4	2	4	4	2	4	2	4	2	3	1			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr11:66191328C>T	uc001ohx.1	+	7	1143	c.967C>T	c.(967-969)CGC>TGC	p.R323C	NPAS4_uc010rpc.1_Missense_Mutation_p.R113C	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	323					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CTGGAGCCTCCGCCAGCAGTT	0.552													28	101					0	0	0	0	T	66191328	T	T	66191328	3	4	198	1	0	0	0	0	1	0	0	0	10619	652	23	1	993	1	NPAS4	11	66191328	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08	65995320	66191328	68815188	30	36432											
LRFN4	78999	broad.mit.edu	37	chr11	66627262	66627262	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccatttctccacgctgccgGcctcgcccctgtgccacgcc	3	8	8	22	4	1	0	0	0	1	0	3	0	1	0	8	1	2	1	8	1	0	1			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr11:66627262G>T	uc001ojr.2	+	2	1844	c.1504G>T	c.(1504-1506)GCC>TCC	p.A502S	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojs.2_Intron	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	502	Extracellular (Potential).					integral to membrane					0						CACGCTGCCGGCCTCGCCCCT	0.692													4	11					0.00024832	0.000370223	1	0	T	66627262	T	T	66627262	3	4	198	1	0	0	0	0	1	0	0	0	8990	1203	42	4	1510	4	LRFN4	11	66627262	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08	435934	66627262	68379254	31	36433											
NUMA1	4926	broad.mit.edu	37	chr11	71725192	71725192	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgcagtgcctccagcttgggGcctgttggctctgtcctgcc	2	11	13	15	1	1	0	0	0	1	0	3	0	3	0	5	3	3	4	5	3	0	2			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr11:71725192G>A	uc001orl.1	-	15	3529	c.3357C>T	c.(3355-3357)GGC>GGT	p.G1119G	NUMA1_uc009ysw.1_Silent_p.G682G|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Silent_p.G1119G|NUMA1_uc001orn.2_Silent_p.G682G|NUMA1_uc009ysx.1_Silent_p.G1119G|NUMA1_uc001oro.1_Silent_p.G1119G	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1119	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CCAGCTTGGGGCCTGTTGGCT	0.602			T	RARA	APL								33	61					0	0	0	0	A	71725192	A	A	71725192	2	1	198	1	0	0	0	0	0	0	0	1	10804	1190	42	4		4	NUMA1	11	71725192	Silent	SNP	G	TCGA-CV-6939-01A-11D-1912-08	5097930	71725192	63281324	32	36434											
FCHSD2	9873	broad.mit.edu	37	chr11	72696108	72696108	+	Frame_Shift_Del	DEL	T	-	-																															acacttattgaaaacttaccTttacacttgccttctgtaaa																										TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr11:72696108delT	uc009ytl.2	-	7	796	c.575delA	c.(574-576)AAGfs	p.K192fs	FCHSD2_uc010rrg.1_Frame_Shift_Del_p.K32fs|FCHSD2_uc001oth.3_Frame_Shift_Del_p.K136fs|FCHSD2_uc001oti.2_Frame_Shift_Del_p.K151fs	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	192							protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			AAAACTTACCTTTACACTTGC	0.264													---	---	---								-	72696108	-	-	72696108	7	5	198	1	0	1	0	1	0	0	0	0	5822	1623	56	0	1703	0	FCHSD2	11	72696108	Frame_Shift_Del	DEL	T	TCGA-CV-6939-01A-11D-1912-08	970916	72696108	62310408	33	36435											
TBCEL	219899	broad.mit.edu	37	chr11	120957788	120957788	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atggagataaaatttacgtgGaatccaaaacaaaataacct	20	9	6	6	1	0	1	0	0	0	1	1	3	1	2	2	2	3	0	2	2	9	4			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr11:120957788G>C	uc009zay.2	+	8	1336	c.1258G>C	c.(1258-1260)GAA>CAA	p.E420Q	TBCEL_uc001pxo.2_Missense_Mutation_p.E420Q|TBCEL_uc001pxp.2_Missense_Mutation_p.E276Q|TBCEL_uc001pxq.2_RNA	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	420	Ubiquitin-like.					cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		AATTTACGTGGAATCCAAAAC	0.413													8	16					0	0	0	0	C	120957788	C	C	120957788	3	2	198	1	0	0	0	0	1	0	0	0	15701	1175	41	2	1284	2	TBCEL	11	120957788	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08	48261680	120957788	14048728	34	36436											
ACAD10	80724	broad.mit.edu	37	chr12	112182675	112182675	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcttccccagctcatacctCaaggggaggtctggttatct	8	11	10	12	0	4	0	2	0	2	0	5	1	5	1	3	4	3	3	3	4	3	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr12:112182675C>T	uc001tsq.2	+	13	2143	c.1943C>T	c.(1942-1944)TCA>TTA	p.S648L	ACAD10_uc001tsp.2_Missense_Mutation_p.S648L|ACAD10_uc009zvx.2_Missense_Mutation_p.S679L|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	648							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						GCTCATACCTCAAGGGGAGGT	0.582													4	58					0	0	0	0	T	112182675	T	T	112182675	3	4	198	1	0	0	0	0	1	0	0	0	108	838	29	2	2086	2	ACAD10	12	112182675	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08		112182675	21669220	35	36437											
RB1	5925	broad.mit.edu	37	chr13	49039220	49039220	+	Frame_Shift_Del	DEL	A	-	-																															ttcatgcagagactgaaaacAaatattttgcagtatgcttc																										TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr13:49039220delA	uc001vcb.2	+	22	2464	c.2298delA	c.(2296-2298)ACAfs	p.T766fs		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	766	Interaction with LIMD1.|Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(8)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GACTGAAAACAAATATTTTGC	0.338		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			---	---	---								-	49039220	-	-	49039220	7	5	198	1	0	1	0	1	0	0	0	0	13163	117	5	0	2384	0	RB1	13	49039220	Frame_Shift_Del	DEL	A	TCGA-CV-6939-01A-11D-1912-08		49039220	66130658	36	36438											
SLITRK5	26050	broad.mit.edu	37	chr13	88329290	88329290	+	Frame_Shift_Del	DEL	G	-	-																															ttgccagtgagtggagttttGgaccagctgaagtcactcat																										TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr13:88329290delG	uc001vln.2	+	2	1866	c.1647delG	c.(1645-1647)TTGfs	p.L549fs	SLITRK5_uc010tic.1_Frame_Shift_Del_p.L308fs	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	549	Extracellular (Potential).|LRR 12.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GTGGAGTTTTGGACCAGCTGA	0.537													---	---	---								-	88329290	-	-	88329290	7	5	198	1	0	1	0	1	0	0	0	0	14810	1339	47	0	1649	0	SLITRK5	13	88329290	Frame_Shift_Del	DEL	G	TCGA-CV-6939-01A-11D-1912-08	39290070	88329290	26840588	37	36439											
SLC15A1	6564	broad.mit.edu	37	chr13	99340612	99340612	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcttattgtgaagccttttcTatcaaaataaagaataatat	16	15	5	5	0	2	2	1	1	1	1	2	2	2	2	1	0	1	1	1	0	10	8			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr13:99340612T>C	uc001vno.2	-	20	1652	c.1575_splice	c.e20-1	p.I525_splice		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide						digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	AAGCCTTTTCTATCAAAATAA	0.303													3	57					0	0	0	0	C	99340612	C	C	99340612	5	2	198	1	0	0	0	0	0	0	1	0	14463	1536	53	5	569	5	SLC15A1	13	99340612	Splice_Site	SNP	T	TCGA-CV-6939-01A-11D-1912-08	11011322	99340612	15829266	38	36440											
TRAF3	7187	broad.mit.edu	37	chr14	103363738	103363738	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaaaatccttcatttacaGgtaagaatcttaggactacg	14	12	6	9	1	2	1	1	0	1	1	4	2	4	2	2	2	2	1	2	2	7	6			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr14:103363738G>A	uc001ymc.1	+	10	1313	c.960G>A	c.(958-960)CAG>CAA	p.Q320Q	TRAF3_uc001yme.1_Silent_p.Q295Q|TRAF3_uc001ymd.1_Silent_p.Q320Q|TRAF3_uc010txy.1_Silent_p.Q237Q	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	320	Potential.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		TTCATTTACAGGTAAGAATCT	0.403													3	16					0	0	0	0	A	103363738	A	A	103363738	2	1	198	1	0	0	0	0	0	0	0	1	16506	1014	35	4		4	TRAF3	14	103363738	Silent	SNP	G	TCGA-CV-6939-01A-11D-1912-08		103363738	3985802	39	36441											
NEDD4	4734	broad.mit.edu	37	chr15	56130006	56130006	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctttaaaagcagccattTgcttctggattcggtttaca	9	15	7	10	1	2	0	0	0	2	0	3	1	2	1	2	2	4	3	2	2	3	7			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr15:56130006T>G	uc002adj.2	-	20	3800	c.3500A>C	c.(3499-3501)CAA>CCA	p.Q1167P	NEDD4_uc002adl.2_Missense_Mutation_p.Q748P|NEDD4_uc002adi.2_Missense_Mutation_p.Q1095P|NEDD4_uc010ugj.1_Missense_Mutation_p.Q1151P|NEDD4_uc010bfm.2_Missense_Mutation_p.Q1150P|NEDD4_uc002adk.2_Intron	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1167	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		AGCAGCCATTTGCTTCTGGAT	0.328													4	19					0	0	0	0	G	56130006	G	G	56130006	3	3	198	1	0	0	0	0	1	0	0	0	10364	1812	63	5	483	5	NEDD4	15	56130006	Missense_Mutation	SNP	T	TCGA-CV-6939-01A-11D-1912-08		56130006	46401386	40	36442											
IQGAP1	8826	broad.mit.edu	37	chr15	91040514	91040516	+	In_Frame_Del	DEL	TCG	-	-																															aacagaagaagttggagactTcgaagtgaaagccaaattca																										TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr15:91040514_91040516delTCG	uc002bpl.1	+	37	4903_4905	c.4802_4804delTCG	c.(4801-4806)TTCGAA>TAA	p.1601_1602FE>*	IQGAP1_uc010uqg.1_In_Frame_Del_p.222_223FE>*	NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1601_1602	C2.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			GTTGGAGACTTCGAAGTGAAAGC	0.345													---	---	---								-	91040516	-	-	91040514	7	5	198	1	0	1	0	1	0	0	0	0	7853	1783	62	0	4948	0	IQGAP1	15	91040514	In_Frame_Del	DEL	TCG	TCGA-CV-6939-01A-11D-1912-08	34910508	91040514	11490878	41	36443											
MYLPF	29895	broad.mit.edu	37	chr16	30387481	30387481	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggccttcactgtgatcGaccagaaccgtgatggtatt	9	10	10	12	2	1	3	1	2	0	1	2	4	1	3	4	2	1	1	4	2	2	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr16:30387481G>T	uc002dxv.1	+	3	168	c.112G>T	c.(112-114)GAC>TAC	p.D38Y		NM_013292	NP_037424	Q96A32	MLRS_HUMAN	myosin light chain, phosphorylatable, fast	38	|EF-hand 1.				skeletal muscle tissue development	muscle myosin complex	calcium ion binding|structural constituent of muscle				0			Colorectal(24;0.193)			CACTGTGATCGACCAGAACCG	0.607													9	45					2.52707e-12	4.06313e-12	1	0	T	30387481	T	T	30387481	3	4	198	1	0	0	0	0	1	0	0	0	10113	1058	37	3	122	3	MYLPF	16	30387481	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08		30387481	59967272	42	36444											
KCTD19	146212	broad.mit.edu	37	chr16	67335719	67335719	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcatccggtaccaccttacGgcttcagtgagtgcagggat	8	11	11	11	2	2	1	2	1	0	0	3	2	3	2	3	3	3	3	3	3	2	4			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr16:67335719G>C	uc002esu.2	-	5	801	c.750C>G	c.(748-750)GCC>GCG	p.A250A	KCTD19_uc002est.2_5'UTR|KCTD19_uc010vjj.1_5'UTR	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	250						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		ACCACCTTACGGCTTCAGTGA	0.468													18	186					0	0	0	0	C	67335719	C	C	67335719	2	2	198	1	0	0	0	0	0	0	0	1	8145	1103	39	3		3	KCTD19	16	67335719	Silent	SNP	G	TCGA-CV-6939-01A-11D-1912-08	36948238	67335719	23019034	43	36445											
MYO15A	51168	broad.mit.edu	37	chr17	18055176	18055176	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggaaggatggcgggaaaGtgttcatgaagcggccagac	13	5	16	7	2	1	2	1	1	0	1	1	5	1	5	1	5	1	1	1	5	3	1			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr17:18055176G>A	uc010vxh.1	+	40	8142	c.7804G>A	c.(7804-7806)GTG>ATG	p.V2602M	MYO15A_uc010vxi.1_5'Flank|MYO15A_uc010vxj.1_5'Flank|MYO15A_uc010vxk.1_5'Flank	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2602	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGGCGGGAAAGTGTTCATGAA	0.567													3	13					0	0	0	0	A	18055176	A	A	18055176	3	1	198	1	0	0	0	0	1	0	0	0	10116	1029	36	4	7958	4	MYO15A	17	18055176	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08		18055176	63140034	44	36446											
IGFBP4	3487	broad.mit.edu	37	chr17	38610286	38610286	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccccatccccaactgcgAccgcaacggcaacttccacc	10	5	5	21	3	0	0	0	0	0	0	3	1	3	0	7	1	4	2	7	1	3	1			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr17:38610286A>G	uc002hus.2	+	3	926	c.614A>G	c.(613-615)GAC>GGC	p.D205G		NM_001552	NP_001543	P22692	IBP4_HUMAN	insulin-like growth factor binding protein 4	205	Thyroglobulin type-1.				DNA metabolic process|signal transduction|skeletal system development						0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			CCCAACTGCGACCGCAACGGC	0.672													3	138					0	0	0	0	G	38610286	G	G	38610286	3	3	198	1	0	0	0	0	1	0	0	0	7620	275	10	5	624	5	IGFBP4	17	38610286	Missense_Mutation	SNP	A	TCGA-CV-6939-01A-11D-1912-08	20555110	38610286	42584924	45	36447											
CDH19	28513	broad.mit.edu	37	chr18	64172339	64172339	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtataggctcctgatctCagcgcttgtggttttccgag	5	14	11	11	2	1	1	1	1	1	0	4	2	3	1	3	2	1	4	3	2	2	5			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr18:64172339C>A	uc002lkc.1	-	12	2167	c.2029G>T	c.(2029-2031)GAG>TAG	p.E677*	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	677	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CTCCTGATCTCAGCGCTTGTG	0.483													47	128					3.54909e-21	5.82051e-21	1	0	A	64172339	A	A	64172339	4	1	198	1	0	0	0	0	0	1	0	0	3119	835	29	2	293	2	CDH19	18	64172339	Nonsense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08		64172339	13904909	46	36448											
DNMT1	1786	broad.mit.edu	37	chr19	10251810	10251810	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcccttccctttgtttccaGggctacgggcatggttggga	4	13	13	11	1	0	0	0	0	0	0	2	1	2	1	3	4	2	4	3	4	1	5			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr19:10251810G>T	uc002mng.2	-	30	3497	c.3317C>A	c.(3316-3318)CCT>CAT	p.P1106H	DNMT1_uc002mne.2_5'Flank|DNMT1_uc002mnf.2_Missense_Mutation_p.P30H|DNMT1_uc010xlc.1_Missense_Mutation_p.P1122H|DNMT1_uc002mnh.2_Missense_Mutation_p.P1001H|DNMT1_uc010xld.1_Missense_Mutation_p.P1106H	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1106					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TTTGTTTCCAGGGCTACGGGC	0.458													6	161					0.000157383	0.000238989	1	0	T	10251810	T	T	10251810	3	4	198	1	0	0	0	0	1	0	0	0	4697	1000	35	4	1577	4	DNMT1	19	10251810	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08		10251810	48877173	47	36449											
ZNF180	7733	broad.mit.edu	37	chr19	44981990	44981990	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattctcattaatcttctgAtgactgtttacagcagcatt	10	17	5	9	0	4	2	2	2	3	0	5	2	4	2	0	0	3	3	0	0	2	6			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr19:44981990A>G	uc002ozf.3	-	5	990	c.708T>C	c.(706-708)CAT>CAC	p.H236H	ZNF180_uc002ozh.3_5'UTR|ZNF180_uc002ozi.3_Silent_p.H209H|ZNF180_uc002ozg.3_Silent_p.H235H|ZNF180_uc010ejm.2_Silent_p.H211H	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	236					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				TAATCTTCTGATGACTGTTTA	0.343													9	67					0	0	0	0	G	44981990	G	G	44981990	2	3	198	1	0	0	0	0	0	0	0	1	17815	330	12	5		5	ZNF180	19	44981990	Silent	SNP	A	TCGA-CV-6939-01A-11D-1912-08	34730180	44981990	14146993	48	36450											
ZNF814	730051	broad.mit.edu	37	chr19	58386284	58386284	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgcaacttacacctcttTgcaaacaacgcctcctcaac	13	9	3	16	1	2	0	1	0	1	0	3	0	3	0	3	0	7	2	3	0	5	2	rs148592080	by1000genomes	TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	1f3cdec6-b587-4045-b1af-0d8d2b26ca44	g.chr19:58386284T>C	uc002qqo.2	-	3	746	c.474A>G	c.(472-474)GCA>GCG	p.A158A	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	158				A -> V (in Ref. 1; BAH13293).	regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TACACCTCTTTGCAAACAACG	0.493													3	87					0	0	0	0	C	58386284	C	C	58386284	2	2	198	1	0	0	0	0	0	0	0	1	18243	1799	63	5		5	ZNF814	19	58386284	Silent	SNP	T	TCGA-CV-6939-01A-11D-1912-08	13404294	58386284	742699	49	36451											
SEL1L2	80343	broad.mit.edu	37	chr20	13856747	13856747	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttttgcggcacggcagcattCccctctaaatacatctagga	10	11	8	12	2	2	0	0	0	2	0	3	1	3	1	2	3	3	3	2	3	4	6			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr20:13856747C>A	uc010gcf.2	-	12	1123	c.1041G>T	c.(1039-1041)GGG>GGT	p.G347G	SEL1L2_uc002woq.3_Silent_p.G208G|SEL1L2_uc010zrl.1_Silent_p.G347G|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	347	Extracellular (Potential).|Sel1-like 6.					integral to membrane	binding			ovary(2)	2						CGGCAGCATTCCCCTCTAAAT	0.308													9	145					0.000274275	0.000401617	1	0	A	13856747	A	A	13856747	2	1	198	1	0	0	0	0	0	0	0	1	14076	842	30	2		2	SEL1L2	20	13856747	Silent	SNP	C	TCGA-CV-6939-01A-11D-1912-08		13856747	49168773	50	36452											
CDK5RAP1	51654	broad.mit.edu	37	chr20	31973565	31973565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacacatgttgtcacagcctCgcatgattgacctggagaag	11	10	10	10	1	1	3	1	2	0	1	2	4	1	3	2	1	2	2	2	1	2	3			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr20:31973565C>T	uc010gek.2	-	7	891	c.767G>A	c.(766-768)CGA>CAA	p.R256Q	CDK5RAP1_uc002wyy.2_Missense_Mutation_p.R166Q|CDK5RAP1_uc002wyz.2_Missense_Mutation_p.R256Q|CDK5RAP1_uc002wza.2_Missense_Mutation_p.R256Q|CDK5RAP1_uc010gel.2_Missense_Mutation_p.R165Q|CDK5RAP1_uc010gem.2_Missense_Mutation_p.R256Q|CDK5RAP1_uc002wzc.1_Missense_Mutation_p.R256Q|CDK5RAP1_uc010gen.2_Missense_Mutation_p.R256Q	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	256					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						GTCACAGCCTCGCATGATTGA	0.493													10	110					0	0	0	0	T	31973565	T	T	31973565	3	4	198	1	0	0	0	0	1	0	0	0	3160	884	31	1	1028	1	CDK5RAP1	20	31973565	Missense_Mutation	SNP	C	TCGA-CV-6939-01A-11D-1912-08	18116818	31973565	31051955	51	36453											
PRPF6	24148	broad.mit.edu	37	chr20	62660829	62660829	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcatgacccccatgtgcTcctggccgtggccaagtgag	7	8	13	13	1	0	3	0	3	0	0	1	3	1	3	5	2	2	2	5	2	1	0			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr20:62660829T>C	uc002yho.2	+	19	2699	c.2531T>C	c.(2530-2532)CTC>CCC	p.L844P	PRPF6_uc002yhp.2_Missense_Mutation_p.L804P	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	844					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					CCCCATGTGCTCCTGGCCGTG	0.592													13	58					0	0	0	0	C	62660829	C	C	62660829	3	2	198	1	0	0	0	0	1	0	0	0	12636	1551	54	5	2605	5	PRPF6	20	62660829	Missense_Mutation	SNP	T	TCGA-CV-6939-01A-11D-1912-08	30687264	62660829	364691	52	36454											
ALG12	79087	broad.mit.edu	37	chr22	50307071	50307071	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttggacatttctaacagcGaaagcacgtaaaccgcgggg	13	7	11	10	4	1	0	0	0	1	0	1	2	1	1	1	3	4	2	1	3	4	4			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chr22:50307071G>A	uc003biy.2	-	3	531	c.257C>T	c.(256-258)TCG>TTG	p.S86L		NM_024105	NP_077010	Q9BV10	ALG12_HUMAN	alpha-1,6-mannosyltransferase ALG12	86	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane					0		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		BRCA - Breast invasive adenocarcinoma(115;0.199)|LUAD - Lung adenocarcinoma(64;0.247)		TTCTAACAGCGAAAGCACGTA	0.552													6	77					0	0	0	0	A	50307071	A	A	50307071	3	1	198	1	0	0	0	0	1	0	0	0	514	1059	37	1	1241	1	ALG12	22	50307071	Missense_Mutation	SNP	G	TCGA-CV-6939-01A-11D-1912-08		50307071	997495	53	36455											
MED12	9968	broad.mit.edu	37	chrX	70339729	70339729	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacgcaactagccaaaaaggTaaggtactgtttcctgtcct	12	10	8	11	1	0	0	0	0	0	0	2	0	2	0	3	2	3	4	3	2	6	4			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chrX:70339729T>G	uc004dyy.2	+	3	595	c.396_splice	c.e3+2	p.K132_splice	MED12_uc011mpq.1_Splice_Site_p.K132_splice|MED12_uc004dyz.2_Splice_Site_p.K132_splice|MED12_uc004dza.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12						androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GCCAAAAAGGTAAGGTACTGT	0.512													4	8					0	0	0	0	G	70339729	G	G	70339729	5	3	198	1	0	0	0	0	0	0	1	0	9481	1652	57	5	408	5	MED12	23	70339729	Splice_Site	SNP	T	TCGA-CV-6939-01A-11D-1912-08		70339729	84930831	54	36456											
GDI1	2664	broad.mit.edu	37	chrX	153667402	153667402	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggtgactcgctacctggacTtcaaggtggtggagggcagc	8	8	16	9	1	1	1	1	1	0	0	2	3	1	3	1	6	2	2	1	6	2	2			TCGA-CV-6939-01A-11D-1912-08	TCGA-CV-6939-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e2e84cc1-2944-489e-be1b-0018a4e723e4	ad47df84-271c-4782-8b59-c04994915ea0	g.chrX:153667402T>G	uc004fli.3	+	4	646	c.304T>G	c.(304-306)TTC>GTC	p.F102V	GDI1_uc011mzo.1_Missense_Mutation_p.F102V	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	102					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTACCTGGACTTCAAGGTGGT	0.577													24	31					0	0	0	0	G	153667402	G	G	153667402	3	3	198	1	0	0	0	0	1	0	0	0	6357	1609	56	5	318	5	GDI1	23	153667402	Missense_Mutation	SNP	T	TCGA-CV-6939-01A-11D-1912-08	83327673	153667402	1603158	55	36457											
PRKCZ	5590	broad.mit.edu	37	chr1	1991000	1991000	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttcccgagcacccctgagCagcctggcctgccatgtccg	5	9	10	17	2	0	1	0	1	0	0	2	2	2	1	7	1	4	2	7	1	0	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:1991000C>A	uc001aiq.2	+	4	465	c.304C>A	c.(304-306)CAG>AAG	p.Q102K		NM_002744	NP_002735	Q05513	KPCZ_HUMAN	protein kinase C, zeta isoform 1	102	Interaction with SQSTM1 (By similarity).				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CACCCCTGAGCAGCCTGGCCT	0.592													6	26					1.06961e-07	1.44245e-07	1	0	A	1991000	A	A	1991000	3	1	199	1	0	0	0	0	1	0	0	0	12579	711	25	4	318	4	PRKCZ	1	1991000	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08		1991000	247259621	1	36458											
DNAJC11	55735	broad.mit.edu	37	chr1	6697514	6697514	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacatgttctcacccattctGgactcttctgcctcaattat	8	15	4	14	0	5	0	2	0	4	0	6	1	5	1	2	1	1	1	2	1	2	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:6697514G>A	uc001aof.2	-	13	1480	c.1374C>T	c.(1372-1374)TCC>TCT	p.S458S	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Silent_p.S406S|DNAJC11_uc010nzu.1_Silent_p.S368S	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	458					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CACCCATTCTGGACTCTTCTG	0.582													96	67					0	0	0	0	A	6697514	A	A	6697514	2	1	199	1	0	0	0	0	0	0	0	1	4652	1335	47	4		4	DNAJC11	1	6697514	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	4706514	6697514	242553107	2	36459											
ANKRD13C	81573	broad.mit.edu	37	chr1	70819809	70819809	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacggggttggtgccggccaGaagggccggggactgggagt	7	5	21	8	3	0	1	0	0	0	1	0	3	0	3	3	8	2	1	3	8	2	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:70819809G>A	uc001dex.3	-	1	609	c.283C>T	c.(283-285)CTG>TTG	p.L95L	ANKRD13C_uc009wbk.2_Silent_p.L95L|ANKRD13C_uc001dey.3_Silent_p.L95L|HHLA3_uc010oqp.1_5'Flank|HHLA3_uc001dfa.2_5'Flank|HHLA3_uc001dfb.2_5'Flank|HHLA3_uc001dfc.2_5'Flank	NM_030816	NP_110443	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	95					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding				0						GTGCCGGCCAGAAGGGCCGGG	0.672													45	17					0	0	0	0	A	70819809	A	A	70819809	2	1	199	1	0	0	0	0	0	0	0	1	643	933	33	2		2	ANKRD13C	1	70819809	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	64122295	70819809	178430812	3	36460											
ELTD1	64123	broad.mit.edu	37	chr1	79412073	79412073	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttagtgcaattagcattttCgccacaggactgagttaaat	12	13	9	7	1	0	1	0	1	0	0	1	2	0	2	1	1	2	4	1	1	5	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:79412073C>T	uc001diq.3	-	3	367	c.211G>A	c.(211-213)GAA>AAA	p.E71K		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	71	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTAGCATTTTCGCCACAGGAC	0.323													18	11					0	0	0	0	T	79412073	T	T	79412073	3	4	199	1	0	0	0	0	1	0	0	0	5108	893	31	1	1913	1	ELTD1	1	79412073	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	8592264	79412073	169838548	4	36461											
ODF2L	57489	broad.mit.edu	37	chr1	86838147	86838148	+	Frame_Shift_Ins	INS	-	T	T																															aatctgtacttccaattcggINSttttttctatcacaattttc																										TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:86838147_86838148insT	uc001dll.1	-	9	1226_1227	c.886_887insA	c.(886-888)ACCfs	p.T296fs	ODF2L_uc001dlm.1_Frame_Shift_Ins_p.T296fs|ODF2L_uc001dln.2_Frame_Shift_Ins_p.T296fs|ODF2L_uc001dlo.2_Frame_Shift_Ins_p.T165fs|ODF2L_uc001dlp.2_Frame_Shift_Ins_p.T296fs|ODF2L_uc010osg.1_Frame_Shift_Ins_p.T296fs|ODF2L_uc001dlq.1_Frame_Shift_Ins_p.T126fs|ODF2L_uc009wcr.1_Frame_Shift_Ins_p.T165fs	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	296	Potential.					centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		TTCCAATTCGGTTTTTTCTATC	0.257													---	---	---								T	86838148	T	T	86838147	7	5	199	1	0	1	1	0	0	0	0	0	10882	1261	44	0	1239	0	ODF2L	1	86838147	Frame_Shift_Ins	INS	-	TCGA-CV-6940-01A-11D-1912-08	7426074	86838147	162412474	5	36462											
GBP7	388646	broad.mit.edu	37	chr1	89613381	89613381	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtcaagagctctgaaagccGcttaagctcagcctgacaat	12	9	9	11	1	3	3	2	2	1	1	3	3	3	3	2	0	4	3	2	0	4	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:89613381G>A	uc001dna.2	-	8	1373	c.1234C>T	c.(1234-1236)CGG>TGG	p.R412W	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	412						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TCTGAAAGCCGCTTAAGCTCA	0.438													137	58					0	0	0	0	A	89613381	A	A	89613381	3	1	199	1	0	0	0	0	1	0	0	0	6314	1086	38	1	698	1	GBP7	1	89613381	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	2775234	89613381	159637240	6	36463											
OLFM3	118427	broad.mit.edu	37	chr1	102312416	102312416	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttactaaggtatccggagtCgacagcctcgtggtgttcag	8	11	12	10	3	1	0	1	0	0	0	4	2	2	1	2	3	2	2	2	3	3	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:102312416C>A	uc001duf.2	-	1	185	c.114G>T	c.(112-114)TCG>TCT	p.S38S	OLFM3_uc001dug.2_Intron|OLFM3_uc001duh.2_Intron|OLFM3_uc001dui.2_Intron|OLFM3_uc001duj.2_Intron|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	38						extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TATCCGGAGTCGACAGCCTCG	0.473													10	54					9.70103e-10	1.33886e-09	1	0	A	102312416	A	A	102312416	2	1	199	1	0	0	0	0	0	0	0	1	10908	899	31	3		3	OLFM3	1	102312416	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	12699035	102312416	146938205	7	36464											
KCNA2	3737	broad.mit.edu	37	chr1	111146468	111146468	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacctagaatctggagacCtttggagtgtctggacaact	10	11	11	9	0	2	3	0	1	2	2	2	6	2	5	2	3	1	0	2	3	3	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:111146468C>A	uc001dzu.2	-	2	1433	c.937G>T	c.(937-939)GGT>TGT	p.G313C	KCNA2_uc009wfv.1_Intron|KCNA2_uc009wfw.2_Missense_Mutation_p.G313C	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	313						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		ATCTGGAGACCTTTGGAGTGT	0.502													21	71					7.41877e-09	1.01792e-08	1	0	A	111146468	A	A	111146468	3	1	199	1	0	0	0	0	1	0	0	0	8042	681	24	4	566	4	KCNA2	1	111146468	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	8834052	111146468	138104153	8	36465											
NBPF10	100132406	broad.mit.edu	37	chr1	145368630	145368630	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaataggttttttactttGacggtgacaagtctccacct	10	14	8	9	1	1	2	0	2	1	0	2	3	1	2	2	2	1	1	2	2	4	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:145368630G>A	uc001end.3	+	86	10868	c.10833G>A	c.(10831-10833)TTG>TTA	p.L3611L	NBPF9_uc010oye.1_Silent_p.L895L|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Silent_p.L464L|NBPF10_uc010oyk.1_Silent_p.L252L|NBPF10_uc010oyl.1_Silent_p.L252L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3536											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTTTTACTTTGACGGTGACAA	0.463													44	311					0	0	0	0	A	145368630	A	A	145368630	2	1	199	1	0	0	0	0	0	0	0	1	10246	1281	45	2		2	NBPF10	1	145368630	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	34222162	145368630	103881991	9	36466											
CRNN	49860	broad.mit.edu	37	chr1	152383333	152383333	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaactttaaacactaagacCaggaattccttgaattccac	15	10	5	11	0	0	2	0	1	0	1	2	3	2	3	3	1	2	1	3	1	6	6			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:152383333C>T	uc001ezx.2	-	3	299	c.225G>A	c.(223-225)CTG>CTA	p.L75L		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	75	EF-hand.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACACTAAGACCAGGAATTCCT	0.542													30	53					0	0	0	0	T	152383333	T	T	152383333	2	4	199	1	0	0	0	0	0	0	0	1	3907	581	21	4		4	CRNN	1	152383333	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	7014703	152383333	96867288	10	36467											
LAMC1	3915	broad.mit.edu	37	chr1	183086740	183086740	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttcgagtggacaggcgaGatactcgcctctctgcagaa	9	9	11	12	3	1	2	0	0	1	2	4	5	1	3	2	2	2	1	2	2	2	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:183086740G>C	uc001gpy.3	+	10	2016	c.1759G>C	c.(1759-1761)GAT>CAT	p.D587H		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	587	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGACAGGCGAGATACTCGCCT	0.507													67	43					0	0	0	0	C	183086740	C	C	183086740	3	2	199	1	0	0	0	0	1	0	0	0	8654	942	33	2	1797	2	LAMC1	1	183086740	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	30703407	183086740	66163881	11	36468											
FAM5C	339479	broad.mit.edu	37	chr1	190068199	190068199	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcgtctcttctgaaaagctgCctaggaggccgttctcattg	7	12	11	11	2	3	1	1	1	3	0	5	2	3	2	2	2	2	2	2	2	3	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:190068199C>T	uc001gse.1	-	8	1482	c.1250G>A	c.(1249-1251)GGC>GAC	p.G417D	FAM5C_uc010pot.1_Missense_Mutation_p.G315D	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	417						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TGAAAAGCTGCCTAGGAGGCC	0.517													4	42					0	0	0	0	T	190068199	T	T	190068199	3	4	199	1	0	0	0	0	1	0	0	0	5626	739	26	4	1054	4	FAM5C	1	190068199	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	6981459	190068199	59182422	12	36469											
ITPKB	3707	broad.mit.edu	37	chr1	226923395	226923395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caggggcaggttgccccgagGgcttccctgcgtctcctcca	4	8	13	16	2	1	0	0	0	1	0	4	1	3	0	5	4	2	3	5	4	0	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr1:226923395G>A	uc010pvo.1	-	2	2105	c.1765C>T	c.(1765-1767)CCT>TCT	p.P589S	ITPKB_uc001hqh.2_Missense_Mutation_p.P589S	NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	589							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				TTGCCCCGAGGGCTTCCCTGC	0.597													11	35					0	0	0	0	A	226923395	A	A	226923395	3	1	199	1	0	0	0	0	1	0	0	0	7957	1232	43	4	1103	4	ITPKB	1	226923395	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	36855196	226923395	22327226	13	36470											
KCNS3	3790	broad.mit.edu	37	chr2	18112572	18112572	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagctgtgcgtattctcattCtgccaggagatcgagtactg	8	12	12	9	2	2	1	1	0	2	1	4	4	2	1	1	1	4	3	1	1	2	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr2:18112572C>T	uc002rcv.2	+	3	748	c.297C>T	c.(295-297)TTC>TTT	p.F99F	KCNS3_uc002rcw.2_Silent_p.F99F	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	99	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TATTCTCATTCTGCCAGGAGA	0.468													37	77					0	0	0	0	T	18112572	T	T	18112572	2	4	199	1	0	0	0	0	0	0	0	1	8129	912	32	2		2	KCNS3	2	18112572	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08		18112572	225086801	14	36471											
KCNS3	3790	broad.mit.edu	37	chr2	18113212	18113212	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcggtaggacttcggtctCtaggtgccacactgagacac	9	9	11	12	2	1	1	0	1	1	1	4	3	1	2	1	4	1	1	1	4	2	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr2:18113212C>T	uc002rcv.2	+	3	1388	c.937C>T	c.(937-939)CTA>TTA	p.L313L	KCNS3_uc002rcw.2_Silent_p.L313L	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	313	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					ACTTCGGTCTCTAGGTGCCAC	0.498													44	103					0	0	0	0	T	18113212	T	T	18113212	2	4	199	1	0	0	0	0	0	0	0	1	8129	912	32	2		2	KCNS3	2	18113212	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	640	18113212	225086161	15	36472											
ZFP36L2	678	broad.mit.edu	37	chr2	43452849	43452849	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgtccccaccgccttcttgtCcagcatgttgttcaggttga	5	13	9	14	2	2	1	1	1	1	0	4	1	4	1	5	1	1	4	5	1	0	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr2:43452849C>T	uc002rsv.3	-	2	385	c.94G>A	c.(94-96)GAC>AAC	p.D32N	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	32					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GCCTTCTTGTCCAGCATGTTG	0.642													7	18					0	0	0	0	T	43452849	T	T	43452849	3	4	199	1	0	0	0	0	1	0	0	0	17714	855	30	2	1394	2	ZFP36L2	2	43452849	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	25339637	43452849	199746524	16	36473											
TACR1	6869	broad.mit.edu	37	chr2	75347732	75347732	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atcttgttcggatgctctggCcattcgatcatgcacacgac	8	12	9	12	3	3	0	1	0	2	0	5	3	3	1	1	2	2	3	1	2	0	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr2:75347732C>T	uc002sng.2	-	2	1137	c.552G>A	c.(550-552)TGG>TGA	p.W184*	TACR1_uc002snh.2_Nonsense_Mutation_p.W184*	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	184	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	GATGCTCTGGCCATTCGATCA	0.547													16	104					0	0	0	0	T	75347732	T	T	75347732	4	4	199	1	0	0	0	0	0	1	0	0	15571	740	26	4	691	4	TACR1	2	75347732	Nonsense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	31894883	75347732	167851641	17	36474											
C2orf55	343990	broad.mit.edu	37	chr2	99448936	99448936	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcaggaagcccccctggagGaggtggtggccccattttca	7	7	15	12	0	1	0	1	0	0	0	1	3	1	3	5	7	1	1	5	7	1	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr2:99448936G>A	uc002szf.1	-	5	709	c.415C>T	c.(415-417)CCT>TCT	p.P139S		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	139											0						CCCCCTGGAGGAGGTGGTGGC	0.502													24	48					0	0	0	0	A	99448936	A	A	99448936	3	1	199	1	0	0	0	0	1	0	0	0	2186	1174	41	2	2497	2	C2orf55	2	99448936	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	24101204	99448936	143750437	18	36475											
NFE2L2	4780	broad.mit.edu	37	chr2	178098810	178098810	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggagaaattcacctgtctCttcatctagttgtaactgag	10	14	9	8	0	4	2	2	1	2	1	5	3	4	2	1	1	1	2	1	1	3	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr2:178098810C>G	uc002ulh.3	-	2	790	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63Q|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63Q|NFE2L2_uc002uli.3_Missense_Mutation_p.E63Q|NFE2L2_uc010fra.2_Missense_Mutation_p.E63Q|NFE2L2_uc010frb.2_Missense_Mutation_p.E63Q	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			39	75					0	0	0	0	G	178098810	G	G	178098810	3	3	199	1	0	0	0	0	1	0	0	0	10422	922	32	2	1598	2	NFE2L2	2	178098810	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	78649874	178098810	65100563	19	36476											
TTN	7273	broad.mit.edu	37	chr2	179606289	179606289	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcattactggccatacatgTatactctccctcatcctcca	9	13	4	15	0	3	0	2	0	1	0	6	0	5	0	4	1	3	1	4	1	4	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr2:179606289T>G	uc010zfh.1	-	46	11382	c.11158A>C	c.(11158-11160)ACA>CCA	p.T3720P	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.T3653P|TTN_uc010zfj.1_Missense_Mutation_p.T3528P|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCATACATGTATACTCTCCC	0.393													18	126					0	0	0	0	G	179606289	G	G	179606289	3	3	199	1	0	0	0	0	1	0	0	0	16803	1638	57	5	93118	5	TTN	2	179606289	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08	1507479	179606289	63593084	20	36477											
ABCB6	10058	broad.mit.edu	37	chr2	220078866	220078866	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atatttgatgatggcctctcGatagcgttccacttcgtaac	9	14	8	10	3	1	2	0	2	1	0	4	3	2	2	2	1	2	2	2	1	3	6			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr2:220078866G>A	uc002vkc.1	-	8	1706	c.1429C>T	c.(1429-1431)CGA>TGA	p.R477*	ABCB6_uc010fwe.1_Nonsense_Mutation_p.R431*|ABCB6_uc010zku.1_RNA	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	477	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATGGCCTCTCGATAGCGTTCC	0.478													34	103					0	0	0	0	A	220078866	A	A	220078866	4	1	199	1	0	0	0	0	0	1	0	0	45	1066	37	1	1147	1	ABCB6	2	220078866	Nonsense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	40472577	220078866	23120507	21	36478											
SETD5	55209	broad.mit.edu	37	chr3	9488977	9488977	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtgtgaatacccggaggTcttcccaagcaggggtaaga	10	9	14	8	1	1	2	0	1	1	1	2	3	2	3	2	5	2	2	2	5	4	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:9488977T>C	uc003brt.2	+	14	2203	c.1768T>C	c.(1768-1770)TCT>CCT	p.S590P	SETD5_uc003brs.1_Missense_Mutation_p.S571P|SETD5_uc003bru.2_Missense_Mutation_p.S492P|SETD5_uc003brv.2_Missense_Mutation_p.S479P|SETD5_uc010hck.2_Missense_Mutation_p.S72P|SETD5_uc003brx.2_Missense_Mutation_p.S259P	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	590										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		TACCCGGAGGTCTTCCCAAGC	0.423													48	106					0	0	0	0	C	9488977	C	C	9488977	3	2	199	1	0	0	0	0	1	0	0	0	14199	1667	58	5	1814	5	SETD5	3	9488977	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08		9488977	188533453	22	36479											
HACL1	26061	broad.mit.edu	37	chr3	15642612	15642612	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaccgcttgctcattcctCatcccgatgtacttgatgcc	6	13	6	16	2	3	1	3	1	0	0	5	2	5	1	4	0	3	3	4	0	1	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:15642612C>G	uc003caf.2	-	2	331	c.171G>C	c.(169-171)ATG>ATC	p.M57I	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Missense_Mutation_p.M57I|HACL1_uc011avt.1_Missense_Mutation_p.M57I|HACL1_uc003cag.2_5'UTR|HACL1_uc011avu.1_Missense_Mutation_p.M57I|HACL1_uc010hep.2_Missense_Mutation_p.M57I|BTD_uc011avv.1_5'Flank|BTD_uc003cah.2_5'Flank|BTD_uc011avw.1_5'Flank|BTD_uc011avx.1_5'Flank	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	57					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						GCTCATTCCTCATCCCGATGT	0.493													8	24					0	0	0	0	G	15642612	G	G	15642612	3	3	199	1	0	0	0	0	1	0	0	0	6980	826	29	2	1629	2	HACL1	3	15642612	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	6153635	15642612	182379818	23	36480											
DAG1	1605	broad.mit.edu	37	chr3	49570156	49570156	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgccgcccacagaagtgcctGacagggaccctgagaagagc	11	3	13	14	2	0	4	0	2	0	3	0	6	0	5	4	1	2	0	4	1	2	0			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:49570156G>C	uc003cxc.3	+	3	2630	c.2212G>C	c.(2212-2214)GAC>CAC	p.D738H		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	738	Extracellular (Potential).				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		AGAAGTGCCTGACAGGGACCC	0.592													6	18					0	0	0	0	C	49570156	C	C	49570156	3	2	199	1	0	0	0	0	1	0	0	0	4242	1290	45	2	2218	2	DAG1	3	49570156	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	33927544	49570156	148452274	24	36481											
FAM116A	201627	broad.mit.edu	37	chr3	57616485	57616485	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttattctagaggttagctGaggtcctgttttctcaagtg	7	18	10	6	0	2	2	1	1	2	1	4	2	3	2	1	2	1	3	1	2	4	7			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:57616485G>C	uc003dja.2	-	17	1545	c.1474C>G	c.(1474-1476)CAG>GAG	p.Q492E		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	492										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		GAGGTTAGCTGAGGTCCTGTT	0.353													10	25					0	0	0	0	C	57616485	C	C	57616485	3	2	199	1	0	0	0	0	1	0	0	0	5435	1299	45	2	368	2	FAM116A	3	57616485	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	8046329	57616485	140405945	25	36482											
ATP6V1A	523	broad.mit.edu	37	chr3	113497631	113497631	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaagctacccaaaatactcGatgaagataaagaaagcaca	20	5	6	10	1	0	3	0	1	0	2	1	4	0	3	2	0	4	2	2	0	9	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:113497631G>A	uc003eao.2	+	2	97	c.31G>A	c.(31-33)GAT>AAT	p.D11N	ATP6V1A_uc011bik.1_5'UTR	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	11					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						CAAAATACTCGATGAAGATAA	0.294													5	34					0	0	0	0	A	113497631	A	A	113497631	3	1	199	1	0	0	0	0	1	0	0	0	1179	1058	37	1	33	1	ATP6V1A	3	113497631	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	55881146	113497631	84524799	26	36483											
FBXO40	51725	broad.mit.edu	37	chr3	121340738	121340738	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaaactagagaggctacTgaggaggaaccaactatgaa	17	5	11	8	0	0	4	0	2	0	2	0	7	0	6	2	3	4	1	2	3	7	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:121340738T>C	uc003eeg.2	+	3	672	c.462T>C	c.(460-462)ACT>ACC	p.T154T		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	154					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		GAGAGGCTACTGAGGAGGAAC	0.507													24	23					0	0	0	0	C	121340738	C	C	121340738	2	2	199	1	0	0	0	0	0	0	0	1	5781	1567	55	5		5	FBXO40	3	121340738	Silent	SNP	T	TCGA-CV-6940-01A-11D-1912-08	7843107	121340738	76681692	27	36484											
HPS3	84343	broad.mit.edu	37	chr3	148880010	148880010	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agggacagattgttccaaccGagcttgcacttcacttgaag	11	10	10	10	1	1	2	1	1	0	1	2	4	2	3	2	1	3	3	2	1	2	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:148880010G>A	uc003ewu.1	+	12	2322	c.2182G>A	c.(2182-2184)GAG>AAG	p.E728K	HPS3_uc011bnq.1_Missense_Mutation_p.E563K|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	728						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TGTTCCAACCGAGCTTGCACT	0.428									Hermansky-Pudlak_syndrome				15	88					0	0	0	0	A	148880010	A	A	148880010	3	1	199	1	0	0	0	0	1	0	0	0	7379	1059	37	1	2228	1	HPS3	3	148880010	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	27539272	148880010	49142420	28	36485											
SLC7A14	57709	broad.mit.edu	37	chr3	170198315	170198315	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgagatgtagtcagaacCaaagatgatgaaggagcaga	16	7	12	6	0	2	6	1	3	1	4	2	8	2	7	1	1	2	2	1	1	4	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:170198315C>A	uc003fgz.2	-	7	2072	c.1756G>T	c.(1756-1758)GGT>TGT	p.G586C	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	586						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			TAGTCAGAACCAAAGATGATG	0.552													12	56					0.00010058	0.000130422	1	0	A	170198315	A	A	170198315	3	1	199	1	0	0	0	0	1	0	0	0	14760	594	21	4	567	4	SLC7A14	3	170198315	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	21318305	170198315	27824115	29	36486											
CCDC39	339829	broad.mit.edu	37	chr3	180359892	180359892	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtataattgctgttttCttttttctagggaaagaact	9	19	8	5	0	2	1	0	0	2	1	2	2	2	2	0	1	2	3	0	1	5	9			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:180359892C>A	uc010hxe.2	-	13	1878	c.1763G>T	c.(1762-1764)AGA>ATA	p.R588I	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	588	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTGCTGTTTTCTTTTTTCTAG	0.358													30	87					9.80776e-20	1.41136e-19	1	0	A	180359892	A	A	180359892	3	1	199	1	0	0	0	0	1	0	0	0	2824	913	32	2	1094	2	CCDC39	3	180359892	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	10161577	180359892	17662538	30	36487											
ABCC5	10057	broad.mit.edu	37	chr3	183707056	183707056	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagagcactcaagccatgaTggtactttcccttgggatgc	9	11	10	11	0	2	2	2	1	0	1	3	3	3	3	2	2	4	2	2	2	2	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:183707056T>C	uc003fmg.2	-	3	410	c.245A>G	c.(244-246)CAT>CGT	p.H82R	ABCC5_uc011bqt.1_5'UTR|ABCC5_uc010hxl.2_Missense_Mutation_p.H82R|ABCC5_uc003fmh.2_Missense_Mutation_p.H82R|ABCC5_uc010hxm.2_RNA|ABCC5_uc010hxn.2_Missense_Mutation_p.H82R|ABCC5_uc010hxo.2_Missense_Mutation_p.H82R	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	82						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CAAGCCATGATGGTACTTTCC	0.502													23	54					0	0	0	0	C	183707056	C	C	183707056	3	2	199	1	0	0	0	0	1	0	0	0	56	1464	51	5	4220	5	ABCC5	3	183707056	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08	3347164	183707056	14315374	31	36488											
ATP13A3	79572	broad.mit.edu	37	chr3	194167697	194167697	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagctgtccacaaatatttaTtctttgaggactgatacaga	13	13	8	7	0	1	3	0	2	1	1	2	5	2	4	1	1	2	1	1	1	4	6			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr3:194167697T>C	uc003fty.3	-	13	1858	c.1456A>G	c.(1456-1458)ATA>GTA	p.I486V	ATP13A3_uc003ftz.1_Missense_Mutation_p.I192V	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	486					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CAAATATTTATTCTTTGAGGA	0.383													51	106					0	0	0	0	C	194167697	C	C	194167697	3	2	199	1	0	0	0	0	1	0	0	0	1127	1493	52	5	2304	5	ATP13A3	3	194167697	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08	10460641	194167697	3854733	32	36489											
PHOX2B	8929	broad.mit.edu	37	chr4	41747993	41748013	+	In_Frame_Del	DEL	GCCGCCGCTGCCGCTGCCGCC	-	-																															ccgcagccaggcctccagctGccgccgctgccgctgccgcc																								rs17879189		TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr4:41747993_41748013delGCCGCCGCTGCCGCTGCCGCC	uc003gwf.3	-	3	1116_1136	c.756_776delGGCGGCAGCGGCAGCGGCGGC	c.(754-777)GCGGCGGCAGCGGCAGCGGCGGCA>GCA	p.252_259AAAAAAAA>A		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	252_259	Poly-Ala.		Missing.		positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						GCCTCCAgctgccgccgctgccgctgccgccgccgccgctg	0.376			Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				---	---	---								-	41748013	-	-	41747993	7	5	199	1	0	1	0	1	0	0	0	0	11914	1319	46	0	172	0	PHOX2B	4	41747993	In_Frame_Del	DEL	GCCGCCGCTGCCGCTGCCGCC	TCGA-CV-6940-01A-11D-1912-08		41747993	149406283	33	36490											
NIPAL1	152519	broad.mit.edu	37	chr4	48036925	48036925	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttatcttcctactttttaaaCgagcacttgaacattcatgg	11	16	5	9	1	2	1	1	1	1	0	3	2	3	1	1	1	4	1	1	1	5	8	rs138156539	byFrequency	TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr4:48036925C>T	uc003gxw.2	+	5	555	c.489C>T	c.(487-489)AAC>AAT	p.N163N		NM_207330	NP_997213	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	163	Cytoplasmic (Potential).					integral to membrane					0						ACTTTTTAAACGAGCACTTGA	0.383													23	26					0	0	0	0	T	48036925	T	T	48036925	2	4	199	1	0	0	0	0	0	0	0	1	10478	535	19	1		1	NIPAL1	4	48036925	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	6288932	48036925	143117351	34	36491											
TEC	7006	broad.mit.edu	37	chr4	48172263	48172263	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atggaataaaatgaatacttActgctctcaaaaagattgta	18	12	6	5	0	1	2	1	1	1	1	2	3	1	3	0	1	3	2	0	1	9	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr4:48172263A>C	uc003gxz.2	-	5	545	c.454_splice	c.e5+1	p.S152_splice		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase						intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						ATGAATACTTACTGCTCTCAA	0.318													16	50					0	0	0	0	C	48172263	C	C	48172263	5	2	199	1	0	0	0	0	0	0	1	0	15808	405	14	5	1495	5	TEC	4	48172263	Splice_Site	SNP	A	TCGA-CV-6940-01A-11D-1912-08	135338	48172263	142982013	35	36492											
PPEF2	5470	broad.mit.edu	37	chr4	76794404	76794404	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caaaataacagcctcctcctCgaatagtgttggccttgcag	11	10	8	12	1	0	0	0	0	0	0	3	1	2	0	4	1	3	2	4	1	5	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr4:76794404C>T	uc003hix.2	-	12	1739	c.1382G>A	c.(1381-1383)CGA>CAA	p.R461Q	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.R461Q	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	461	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GCCTCCTCCTCGAATAGTGTT	0.458													41	32					0	0	0	0	T	76794404	T	T	76794404	3	4	199	1	0	0	0	0	1	0	0	0	12363	884	31	1	903	1	PPEF2	4	76794404	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	28622141	76794404	114359872	36	36493											
DMP1	1758	broad.mit.edu	37	chr4	88583266	88583266	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagatgacagtggagatgaCacctttggtgacgatgacag	13	8	14	6	1	0	6	0	4	0	2	0	9	0	6	1	2	0	0	1	2	1	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr4:88583266C>A	uc003hqv.2	+	6	440	c.336C>A	c.(334-336)GAC>GAA	p.D112E	DMP1_uc003hqw.2_Missense_Mutation_p.D96E	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	112					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		GTGGAGATGACACCTTTGGTG	0.478													25	20					2.39556e-15	3.40574e-15	1	0	A	88583266	A	A	88583266	3	1	199	1	0	0	0	0	1	0	0	0	4605	477	17	4	354	4	DMP1	4	88583266	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	11788862	88583266	102571010	37	36494											
MTTP	4547	broad.mit.edu	37	chr4	100534246	100534246	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgctgtcagcatctggCgaccctatcagtgtggtgaa	11	10	11	9	1	3	1	2	1	1	0	3	2	3	1	1	2	2	2	1	2	4	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr4:100534246C>T	uc003hvc.3	+	16	2422	c.2166C>T	c.(2164-2166)GGC>GGT	p.G722G	MTTP_uc011cej.1_Silent_p.G749G	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	722					lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	CAGCATCTGGCGACCCTATCA	0.338													11	60					0	0	0	0	T	100534246	T	T	100534246	2	4	199	1	0	0	0	0	0	0	0	1	10017	755	27	1		1	MTTP	4	100534246	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	11950980	100534246	90620030	38	36495											
KLHL2	11275	broad.mit.edu	37	chr4	166231784	166231784	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttcgcactgtagattcctaCgaccctgtgaaggaccagtg	9	10	11	11	2	0	2	0	1	0	1	2	4	1	3	3	1	1	3	3	1	3	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr4:166231784C>T	uc003irb.2	+	10	1378	c.1119C>T	c.(1117-1119)TAC>TAT	p.Y373Y	KLHL2_uc011cjm.1_Silent_p.Y377Y|KLHL2_uc003irc.2_Silent_p.Y285Y|KLHL2_uc010ira.2_Silent_p.Y26Y	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	373	Kelch 2.				intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		TAGATTCCTACGACCCTGTGA	0.478													94	394					0	0	0	0	T	166231784	T	T	166231784	2	4	199	1	0	0	0	0	0	0	0	1	8413	547	19	1		1	KLHL2	4	166231784	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	65697538	166231784	24922492	39	36496											
SPOCK3	50859	broad.mit.edu	37	chr4	167675844	167675844	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttaaacatccagccaagtGagtccttgcaaattggcaag	13	10	9	9	0	0	1	0	1	0	0	2	1	2	1	3	1	3	3	3	1	5	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr4:167675844G>C	uc003iri.1	-	9	896	c.755C>G	c.(754-756)TCA>TGA	p.S252*	SPOCK3_uc011cjp.1_Nonsense_Mutation_p.S209*|SPOCK3_uc011cjq.1_Nonsense_Mutation_p.S261*|SPOCK3_uc011cjr.1_Nonsense_Mutation_p.S132*|SPOCK3_uc003irj.1_Nonsense_Mutation_p.S249*|SPOCK3_uc011cjs.1_Nonsense_Mutation_p.S201*|SPOCK3_uc011cjt.1_Nonsense_Mutation_p.S160*|SPOCK3_uc011cju.1_Nonsense_Mutation_p.S145*|SPOCK3_uc011cjv.1_Nonsense_Mutation_p.S154*|SPOCK3_uc003irk.3_Nonsense_Mutation_p.S249*	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	252					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		CCAGCCAAGTGAGTCCTTGCA	0.373													16	65					0	0	0	0	C	167675844	C	C	167675844	4	2	199	1	0	0	0	0	0	1	0	0	15147	1294	45	2	571	2	SPOCK3	4	167675844	Nonsense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	1444060	167675844	23478432	40	36497											
HK3	3101	broad.mit.edu	37	chr5	176308438	176308438	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcagccctctgggacacaGcctggcacacctctagcacc	8	5	11	17	0	2	0	0	0	2	0	2	1	2	1	4	3	3	3	4	3	1	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr5:176308438G>T	uc003mfa.2	-	18	2584	c.2492C>A	c.(2491-2493)GCT>GAT	p.A831D	HK3_uc003mez.2_Missense_Mutation_p.A387D	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	831	Catalytic.			A -> V (in Ref. 4; AAC50422).	glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGGACACAGCCTGGCACAC	0.652													3	21					6.4e-05	8.39111e-05	1	0	T	176308438	T	T	176308438	3	4	199	1	0	0	0	0	1	0	0	0	7231	971	34	4	287	4	HK3	5	176308438	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08		176308438	4606822	41	36498											
ZNF346	23567	broad.mit.edu	37	chr5	176477792	176477792	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatagacccagacaagttCtgcagcctctgccatgcaac	12	8	8	13	0	2	3	0	1	2	2	2	3	2	3	3	0	5	3	3	0	3	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr5:176477792C>A	uc003mfi.2	+	5	601	c.558C>A	c.(556-558)TTC>TTA	p.F186L	ZNF346_uc011dfr.1_Missense_Mutation_p.F154L|ZNF346_uc011dfs.1_Missense_Mutation_p.F88L|ZNF346_uc003mfj.2_Intron|ZNF346_uc003mfk.1_Missense_Mutation_p.F211L|ZNF346_uc011dft.1_Intron	NM_012279	NP_036411	Q9UL40	ZN346_HUMAN	zinc finger protein 346	186	Matrin-type 3.					cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding				0	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGACAAGTTCTGCAGCCTCT	0.478													13	44					1.49906e-05	1.98752e-05	1	0	A	176477792	A	A	176477792	3	1	199	1	0	0	0	0	1	0	0	0	17927	912	32	2	576	2	ZNF346	5	176477792	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	169354	176477792	4437468	42	36499											
TBC1D9B	23061	broad.mit.edu	37	chr5	179294796	179294796	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accttctgaggagctgtcctCtgtgaaataatgggccgcct	8	11	11	11	1	2	2	0	2	2	0	3	3	3	3	4	2	1	1	4	2	2	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr5:179294796C>T	uc003mlh.2	-	18	2882	c.2845G>A	c.(2845-2847)GAG>AAG	p.E949K	TBC1D9B_uc003mli.2_Missense_Mutation_p.E949K|TBC1D9B_uc003mlj.2_Missense_Mutation_p.E949K|TBC1D9B_uc003mlf.2_5'Flank|TBC1D9B_uc003mlg.2_Missense_Mutation_p.E125K|TBC1D9B_uc011dgv.1_Missense_Mutation_p.E125K|TBC1D9B_uc011dgw.1_Missense_Mutation_p.E125K	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	949						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGCTGTCCTCTGTGAAATAA	0.632													8	15					0	0	0	0	T	179294796	T	T	179294796	3	4	199	1	0	0	0	0	1	0	0	0	15694	922	32	2	927	2	TBC1D9B	5	179294796	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	2817004	179294796	1620464	43	36500											
MEP1A	4224	broad.mit.edu	37	chr6	46801214	46801214	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccttgaccaggagcctgaTgtccggaacaggatgtcctc	9	9	11	12	1	0	2	0	2	0	0	4	5	3	5	5	3	2	0	5	3	1	1	rs142787710	byFrequency	TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr6:46801214T>A	uc010jzh.1	+	11	1590	c.1548T>A	c.(1546-1548)GAT>GAA	p.D516E	MEP1A_uc011dwg.1_Missense_Mutation_p.D238E|MEP1A_uc011dwh.1_Missense_Mutation_p.D544E|MEP1A_uc011dwi.1_Missense_Mutation_p.D416E	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	516	MATH.|Extracellular (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			AGGAGCCTGATGTCCGGAACA	0.517													15	141					0	0	0	0	A	46801214	A	A	46801214	3	1	199	1	0	0	0	0	1	0	0	0	9528	1461	51	5	1590	5	MEP1A	6	46801214	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08		46801214	124313853	44	36501											
FAM135A	57579	broad.mit.edu	37	chr6	71232223	71232223	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaattttttaggtacgcaGattttctgaggcattctttt	8	19	9	5	1	2	2	0	1	2	1	2	3	2	3	0	3	1	3	0	3	3	9			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr6:71232223G>C	uc003pfj.2	+	11	1170	c.1037G>C	c.(1036-1038)AGA>ACA	p.R346T	FAM135A_uc003pfi.2_Missense_Mutation_p.R346T|FAM135A_uc003pfh.2_Missense_Mutation_p.R329T|FAM135A_uc003pfk.2_Missense_Mutation_p.R372T|FAM135A_uc003pfl.2_Missense_Mutation_p.R209T|FAM135A_uc003pfn.2_5'Flank|FAM135A_uc003pfo.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	346										central_nervous_system(1)	1						TAGGTACGCAGATTTTCTGAG	0.353													24	139					0	0	0	0	C	71232223	C	C	71232223	3	2	199	1	0	0	0	0	1	0	0	0	5476	942	33	2	1157	2	FAM135A	6	71232223	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	24431009	71232223	99882844	45	36502											
MDN1	23195	broad.mit.edu	37	chr6	90434920	90434920	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaacagcaaatcttacctGagtgaatctgttaaggaaag	15	9	10	7	0	2	2	0	2	2	0	2	3	2	3	1	2	3	3	1	2	6	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr6:90434920G>A	uc003pnn.1	-	38	5784	c.5668C>T	c.(5668-5670)CAG>TAG	p.Q1890*		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	1890					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AATCTTACCTGAGTGAATCTG	0.423													18	68					0	0	0	0	A	90434920	A	A	90434920	4	1	199	1	0	0	0	0	0	1	0	0	9468	1299	45	2	11382	2	MDN1	6	90434920	Nonsense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	19202697	90434920	80680147	46	36503											
SIM1	6492	broad.mit.edu	37	chr6	100911241	100911241	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggatgctttgtccagctgcGaggtgatagccgagggcaaa	9	9	15	8	2	0	1	0	1	0	0	1	4	1	2	2	3	4	3	2	3	2	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr6:100911241G>A	uc003pqj.3	-	1	311	c.104C>T	c.(103-105)TCG>TTG	p.S35L	SIM1_uc010kcu.2_Missense_Mutation_p.S35L	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	35	Helix-loop-helix motif.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GTCCAGCTGCGAGGTGATAGC	0.453													15	58					0	0	0	0	A	100911241	A	A	100911241	3	1	199	1	0	0	0	0	1	0	0	0	14388	1059	37	1	2240	1	SIM1	6	100911241	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	10476321	100911241	70203826	47	36504											
CDK19	23097	broad.mit.edu	37	chr6	111067348	111067348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcaatctctctacaagccGacatggatattcctgtgcct	9	12	7	13	1	2	0	0	0	2	0	4	2	3	1	3	1	4	1	3	1	4	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr6:111067348G>A	uc003puh.1	-	2	258	c.185C>T	c.(184-186)TCG>TTG	p.S62L	CDK19_uc003pui.1_Missense_Mutation_p.S2L	NM_015076	NP_055891	Q9BWU1	CDK19_HUMAN	cell division cycle 2-like 6 (CDK8-like)	62	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TCTACAAGCCGACATGGATAT	0.269													9	109					0	0	0	0	A	111067348	A	A	111067348	3	1	199	1	0	0	0	0	1	0	0	0	3150	1059	37	1	1371	1	CDK19	6	111067348	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	10156107	111067348	60047719	48	36505											
C6orf204	387119	broad.mit.edu	37	chr6	118887087	118887087	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtcctctaacctaagcatctCcatactatcatgtaaacagc	13	11	4	13	0	3	0	1	0	2	0	5	0	4	0	3	0	5	2	3	0	6	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr6:118887087C>G	uc003pxz.1	-	3	1213	c.625G>C	c.(625-627)GAG>CAG	p.E209Q	C6orf204_uc003pya.1_Missense_Mutation_p.E212Q|C6orf204_uc003pyb.2_Missense_Mutation_p.E209Q|C6orf204_uc011ebj.1_Missense_Mutation_p.E107Q|C6orf204_uc003pyc.2_Missense_Mutation_p.E212Q|C6orf204_uc011ebl.1_Missense_Mutation_p.E107Q	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	209						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		CTAAGCATCTCCATACTATCA	0.413													4	157					0	0	0	0	G	118887087	G	G	118887087	3	3	199	1	0	0	0	0	1	0	0	0	2363	864	30	2	1890	2	C6orf204	6	118887087	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	7819739	118887087	52227980	49	36506											
RNF146	81847	broad.mit.edu	37	chr6	127607982	127607982	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaagcggtgtgctctttgtcGacaagaaattcccgaggatt	11	11	11	8	3	1	1	0	0	1	1	3	4	2	2	1	2	2	1	1	2	3	3	rs146049752		TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr6:127607982G>A	uc003qav.2	+	3	383	c.224G>A	c.(223-225)CGA>CAA	p.R75Q	RNF146_uc003qat.2_Missense_Mutation_p.R74Q|RNF146_uc003qau.2_Missense_Mutation_p.R74Q|RNF146_uc003qaw.2_Missense_Mutation_p.R74Q	NM_030963	NP_112225	Q9NTX7	RN146_HUMAN	ring finger protein 146	75	RING-type.				positive regulation of canonical Wnt receptor signaling pathway|protein autoubiquitination|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol	poly-ADP-D-ribose binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1				GBM - Glioblastoma multiforme(226;0.0407)|all cancers(137;0.2)		GCTCTTTGTCGACAAGAAATT	0.443													13	60					0	0	0	0	A	127607982	A	A	127607982	3	1	199	1	0	0	0	0	1	0	0	0	13513	1058	37	1	223	1	RNF146	6	127607982	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	8720895	127607982	43507085	50	36507											
AKAP12	9590	broad.mit.edu	37	chr6	151671694	151671694	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccggaaaagacaaagagaCggggacagacgggatccttg	14	3	16	8	3	0	3	0	0	0	3	1	7	1	6	2	5	0	0	2	5	3	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr6:151671694C>T	uc011eep.1	+	4	2408	c.2168C>T	c.(2167-2169)ACG>ATG	p.T723M	AKAP12_uc003qoe.2_Missense_Mutation_p.T723M|AKAP12_uc003qof.2_Missense_Mutation_p.T625M|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.T618M	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	723					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GACAAAGAGACGGGGACAGAC	0.567													12	133					0	0	0	0	T	151671694	T	T	151671694	3	4	199	1	0	0	0	0	1	0	0	0	448	536	19	1	2207	1	AKAP12	6	151671694	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	24063712	151671694	19443373	51	36508											
AKAP12	9590	broad.mit.edu	37	chr6	151672232	151672232	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgctgacgggacgagggcAgctaccattattgaagaaag	12	7	14	8	3	0	3	0	2	0	1	1	5	0	4	1	2	2	3	1	2	4	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr6:151672232A>G	uc011eep.1	+	4	2946	c.2706A>G	c.(2704-2706)GCA>GCG	p.A902A	AKAP12_uc003qoe.2_Silent_p.A902A|AKAP12_uc003qof.2_Silent_p.A804A|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Silent_p.A797A	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	902					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GGACGAGGGCAGCTACCATTA	0.532													19	52					0	0	0	0	G	151672232	G	G	151672232	2	3	199	1	0	0	0	0	0	0	0	1	448	175	7	5		5	AKAP12	6	151672232	Silent	SNP	A	TCGA-CV-6940-01A-11D-1912-08	538	151672232	19442835	52	36509											
STK31	56164	broad.mit.edu	37	chr7	23830531	23830531	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaacctgcttctccaggttCagacttatatgcttatggct	10	14	7	10	0	2	1	1	0	1	1	3	1	2	1	2	2	3	4	2	2	5	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr7:23830531C>G	uc003sws.3	+	22	2793	c.2726C>G	c.(2725-2727)TCA>TGA	p.S909*	STK31_uc003swt.3_Nonsense_Mutation_p.S886*|STK31_uc011jze.1_Nonsense_Mutation_p.S909*|STK31_uc010kuq.2_Nonsense_Mutation_p.S886*|STK31_uc003swv.1_Nonsense_Mutation_p.S75*	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	909	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TCTCCAGGTTCAGACTTATAT	0.353													10	31					0	0	0	0	G	23830531	G	G	23830531	4	3	199	1	0	0	0	0	0	1	0	0	15362	838	29	2	2812	2	STK31	7	23830531	Nonsense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08		23830531	135308132	53	36510											
NFE2L3	9603	broad.mit.edu	37	chr7	26225363	26225363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccaaagaactggtggcctCaggccacaaaaaggaaaccc	16	3	9	13	0	1	1	1	0	0	1	1	2	1	2	4	4	2	0	4	4	5	0			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr7:26225363C>T	uc003sxq.2	+	4	2317	c.2045C>T	c.(2044-2046)TCA>TTA	p.S682L		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	682					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						CTGGTGGCCTCAGGCCACAAA	0.418													13	41					0	0	0	0	T	26225363	T	T	26225363	3	4	199	1	0	0	0	0	1	0	0	0	10423	838	29	2	2059	2	NFE2L3	7	26225363	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	2394832	26225363	132913300	54	36511											
HIP1	3092	broad.mit.edu	37	chr7	75172195	75172195	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttcgatctgtgatttgccGgaaatggttgaggccacaac	9	12	11	9	2	2	2	0	2	2	0	3	4	2	3	2	3	2	1	2	3	2	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr7:75172195G>A	uc003uds.1	-	28	2906	c.2865C>T	c.(2863-2865)TCC>TCT	p.S955S	HIP1_uc011kfz.1_Silent_p.S781S	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	955	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						GTGATTTGCCGGAAATGGTTG	0.562			T	PDGFRB	CMML								4	98					0	0	0	0	A	75172195	A	A	75172195	2	1	199	1	0	0	0	0	0	0	0	1	7153	1103	39	1		1	HIP1	7	75172195	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	48946832	75172195	83966468	55	36512											
CALCR	799	broad.mit.edu	37	chr7	93055850	93055850	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggcgcctcccccaacgctGgttccactgaattttgaatt	7	11	10	13	2	0	2	0	2	0	0	2	2	2	2	4	3	1	2	4	3	3	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr7:93055850G>A	uc003umv.1	-	15	1606	c.1345C>T	c.(1345-1347)CAG>TAG	p.Q449*	CALCR_uc011kia.1_Nonsense_Mutation_p.Q229*|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Nonsense_Mutation_p.Q415*|CALCR_uc003umw.2_Nonsense_Mutation_p.Q415*	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	431	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CCCCAACGCTGGTTCCACTGA	0.547													45	71					0	0	0	0	A	93055850	A	A	93055850	4	1	199	1	0	0	0	0	0	1	0	0	2591	1357	47	4	185	4	CALCR	7	93055850	Nonsense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	17883655	93055850	66082813	56	36513											
GPC2	221914	broad.mit.edu	37	chr7	99773453	99773453	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctgggcatacaggcggccGtaggagtgggagaagagctg	9	6	19	7	2	0	2	0	0	0	2	0	4	0	3	1	5	3	4	1	5	3	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr7:99773453G>A	uc003utv.2	-	3	558	c.390C>T	c.(388-390)TAC>TAT	p.Y130Y	GPC2_uc010lgr.2_RNA|GPC2_uc003utw.1_Silent_p.Y130Y|STAG3_uc010lgs.1_5'Flank|STAG3_uc003utx.1_5'Flank|STAG3_uc011kjk.1_5'Flank	NM_152742	NP_689955	Q8N158	GPC2_HUMAN	glypican 2 precursor	130						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|pancreas(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACAGGCGGCCGTAGGAGTGGG	0.567													41	50					0	0	0	0	A	99773453	A	A	99773453	2	1	199	1	0	0	0	0	0	0	0	1	6636	1140	40	1		1	GPC2	7	99773453	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	6717603	99773453	59365210	57	36514											
DOCK4	9732	broad.mit.edu	37	chr7	111517169	111517169	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcatggcttgattattattcCcaaggaaaatgcccttggaa	12	13	8	8	0	1	1	1	1	0	0	2	3	2	3	2	3	1	1	2	3	6	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr7:111517169C>T	uc003vfx.2	-	17	1930	c.1661G>A	c.(1660-1662)GGG>GAG	p.G554E	DOCK4_uc003vfw.2_5'UTR|DOCK4_uc003vfy.2_Missense_Mutation_p.G554E|DOCK4_uc003vga.1_Missense_Mutation_p.G159E	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	554	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				ATTATTATTCCCAAGGAAAAT	0.338													13	9					0	0	0	0	T	111517169	T	T	111517169	3	4	199	1	0	0	0	0	1	0	0	0	4711	623	22	4	4383	4	DOCK4	7	111517169	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	11743716	111517169	47621494	58	36515											
JHDM1D	80853	broad.mit.edu	37	chr7	139829433	139829433	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcagctggctgccatgcatcTttataattatttcatcggca	9	15	7	10	1	3	0	2	0	1	0	4	0	3	0	1	2	3	4	1	2	3	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr7:139829433T>C	uc003vvm.2	-	4	423	c.419A>G	c.(418-420)AAG>AGG	p.K140R		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	140					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					GCCATGCATCTTTATAATTAT	0.353													24	47					0	0	0	0	C	139829433	C	C	139829433	3	2	199	1	0	0	0	0	1	0	0	0	7987	1609	56	5	2474	5	JHDM1D	7	139829433	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08	28312264	139829433	19309230	59	36516											
OR9A4	130075	broad.mit.edu	37	chr7	141619410	141619410	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccacttgtgcctcccacttCacctgtgttgtgattggcta	5	15	8	13	0	1	1	1	1	0	0	3	1	3	1	4	1	1	2	4	1	1	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr7:141619410C>T	uc003vwu.1	+	1	735	c.735C>T	c.(733-735)TTC>TTT	p.F245F		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					CCTCCCACTTCACCTGTGTTG	0.502													7	107					0	0	0	0	T	141619410	T	T	141619410	2	4	199	1	0	0	0	0	0	0	0	1	11303	825	29	2		2	OR9A4	7	141619410	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	1789977	141619410	17519253	60	36517											
ABCB8	11194	broad.mit.edu	37	chr7	150741174	150741174	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaccagcgcgctggatgcaGagtccgagcgggttgtacag	8	7	15	11	4	0	1	0	0	0	1	1	3	1	2	2	2	5	4	2	2	2	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr7:150741174G>A	uc003wil.3	+	16	2026	c.1933G>A	c.(1933-1935)GAG>AAG	p.E645K	ABCB8_uc010lpx.2_Missense_Mutation_p.E628K|ABCB8_uc011kvd.1_Missense_Mutation_p.E540K|ABCB8_uc003wim.3_Missense_Mutation_p.E423K|ABCB8_uc003wik.3_Missense_Mutation_p.E628K	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	645	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCTGGATGCAGAGTCCGAGCG	0.667													6	22					0	0	0	0	A	150741174	A	A	150741174	3	1	199	1	0	0	0	0	1	0	0	0	47	943	33	2	1940	2	ABCB8	7	150741174	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	9121764	150741174	8397489	61	36518											
MTUS1	57509	broad.mit.edu	37	chr8	17611659	17611659	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatctcggtgttctgctcAagactgtttgttgtcttgaa	7	16	10	8	1	4	3	1	1	3	2	5	3	4	3	0	1	1	4	0	1	2	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr8:17611659A>C	uc003wxv.2	-	2	2132	c.1658T>G	c.(1657-1659)TTG>TGG	p.L553W	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.L553W|MTUS1_uc010lsz.2_Missense_Mutation_p.L553W	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	553						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		TGTTCTGCTCAAGACTGTTTG	0.428													39	148					0	0	0	0	C	17611659	C	C	17611659	3	2	199	1	0	0	0	0	1	0	0	0	10018	131	5	5	2529	5	MTUS1	8	17611659	Missense_Mutation	SNP	A	TCGA-CV-6940-01A-11D-1912-08		17611659	128752363	62	36519											
CDCA2	157313	broad.mit.edu	37	chr8	25346199	25346199	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagagagcacttcctaagaaGagtcaggtaagcatgtgttt	14	10	11	6	0	1	3	1	0	0	3	2	4	2	3	1	1	2	4	1	1	4	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr8:25346199G>A	uc003xep.1	+	13	2144	c.1665G>A	c.(1663-1665)AAG>AAA	p.K555K	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_Silent_p.K555K|CDCA2_uc003xeq.1_Silent_p.K540K|CDCA2_uc003xer.1_Silent_p.K218K	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	555	Lys-rich.				cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		TTCCTAAGAAGAGTCAGGTAA	0.313													8	29					0	0	0	0	A	25346199	A	A	25346199	2	1	199	1	0	0	0	0	0	0	0	1	3101	933	33	2		2	CDCA2	8	25346199	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	7734540	25346199	121017823	63	36520											
BAG4	9530	broad.mit.edu	37	chr8	38034583	38034583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaccacctggctgggagaaGgcggaggaggcgatggctac	10	4	18	9	2	0	2	0	0	0	2	0	6	0	4	2	7	1	2	2	7	2	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr8:38034583G>A	uc003xky.1	+	1	478	c.196G>A	c.(196-198)GGC>AGC	p.G66S	LSM1_uc003xkw.2_5'Flank|LSM1_uc003xkx.2_5'Flank|BAG4_uc003xkz.1_Missense_Mutation_p.G66S	NM_004874	NP_004865	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	66					anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				GCTGGGAGAAGGCGGAGGAGG	0.672													8	16					0	0	0	0	A	38034583	A	A	38034583	3	1	199	1	0	0	0	0	1	0	0	0	1291	1000	35	4	198	4	BAG4	8	38034583	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	12688384	38034583	108329439	64	36521											
WWP1	11059	broad.mit.edu	37	chr8	87423945	87423945	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtattccttctaccagtgcAgaattggaatctgaagctag	11	13	9	8	0	2	2	0	1	2	1	3	3	3	3	2	1	3	3	2	1	6	6			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr8:87423945A>G	uc003ydt.2	+	9	1183	c.903A>G	c.(901-903)GCA>GCG	p.A301A	WWP1_uc010mai.2_Silent_p.A77A	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	301					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						CTACCAGTGCAGAATTGGAAT	0.403													22	57					0	0	0	0	G	87423945	G	G	87423945	2	3	199	1	0	0	0	0	0	0	0	1	17483	175	7	5		5	WWP1	8	87423945	Silent	SNP	A	TCGA-CV-6940-01A-11D-1912-08	49389362	87423945	58940077	65	36522											
GRHL2	79977	broad.mit.edu	37	chr8	102585906	102585906	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttcacagtggcacatttCagtacaccctggaagccacc	10	10	7	14	0	3	0	2	0	1	0	3	1	3	1	3	2	2	2	3	2	2	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr8:102585906C>T	uc010mbu.2	+	6	1075	c.745C>T	c.(745-747)CAG>TAG	p.Q249*	GRHL2_uc011lhi.1_Nonsense_Mutation_p.Q249*	NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	249						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TGGCACATTTCAGTACACCCT	0.473													44	62					0	0	0	0	T	102585906	T	T	102585906	4	4	199	1	0	0	0	0	0	1	0	0	6803	827	29	2	767	2	GRHL2	8	102585906	Nonsense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	15161961	102585906	43778116	66	36523											
ABRA	137735	broad.mit.edu	37	chr8	107773700	107773700	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcccactgggctatatttCtgttgggctttgcagttgag	5	16	12	8	0	1	1	0	1	1	0	1	1	1	1	1	2	2	5	1	2	2	7			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr8:107773700C>T	uc003ymm.3	-	2	765	c.711G>A	c.(709-711)CAG>CAA	p.Q237Q		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	237					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			GGCTATATTTCTGTTGGGCTT	0.423													19	137					0	0	0	0	T	107773700	T	T	107773700	2	4	199	1	0	0	0	0	0	0	0	1	100	912	32	2		2	ABRA	8	107773700	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	5187794	107773700	38590322	67	36524											
FOXD4	2298	broad.mit.edu	37	chr9	117484	117484	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcaggtagagggaaggggtgGggcaggtgggctcccggggt	6	5	24	6	1	0	1	0	0	0	1	1	2	1	2	1	10	0	4	1	10	2	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr9:117484G>T	uc003zfz.2	-	1	934	c.636C>A	c.(634-636)CCC>CCA	p.P212P		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	212	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GGAAGGGGTGGGGCAGGTGGG	0.716													13	747					9.16793e-09	1.25065e-08	1	0	T	117484	T	T	117484	2	4	199	1	0	0	0	0	0	0	0	1	6031	1219	43	4		4	FOXD4	9	117484	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08		117484	141095947	68	36525											
SMARCA2	6595	broad.mit.edu	37	chr9	2182188	2182188	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcctaggcgacctggagaaGgatgtcatgcttctctgtca	9	10	12	10	1	3	1	2	0	1	1	4	4	3	2	2	3	2	1	2	3	2	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr9:2182188G>C	uc003zhc.2	+	31	4506	c.4407G>C	c.(4405-4407)AAG>AAC	p.K1469N	SMARCA2_uc003zhd.2_Missense_Mutation_p.K1451N|SMARCA2_uc010mha.2_Missense_Mutation_p.K1384N|SMARCA2_uc011llw.1_Missense_Mutation_p.K155N|SMARCA2_uc003zhf.2_Missense_Mutation_p.K133N|SMARCA2_uc011llx.1_Missense_Mutation_p.K115N|SMARCA2_uc003zhe.2_Missense_Mutation_p.K157N|SMARCA2_uc003zhg.2_Missense_Mutation_p.K115N|SMARCA2_uc010mhb.2_Missense_Mutation_p.K139N	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1469	Bromo.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ACCTGGAGAAGGATGTCATGC	0.438													39	508					0	0	0	0	C	2182188	C	C	2182188	3	2	199	1	0	0	0	0	1	0	0	0	14833	991	35	4	4525	4	SMARCA2	9	2182188	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	2064704	2182188	139031243	69	36526											
SIT1	27240	broad.mit.edu	37	chr9	35650526	35650526	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccggatggctcctgctcCggcccctggtccactgggac	3	7	13	18	2	0	0	0	0	0	0	3	2	3	2	7	5	1	2	7	5	0	0			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr9:35650526C>A	uc003zxe.1	-	2	306	c.209G>T	c.(208-210)CGG>CTG	p.R70L	SIT1_uc003zxf.1_Intron	NM_014450	NP_055265	Q9Y3P8	SIT1_HUMAN	SHP2-interacting transmembrane adaptor protein	70	Cytoplasmic (Potential).				regulation of T cell activation|signal transduction	integral to plasma membrane	kinase binding|SH2 domain binding				0			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCTCCTGCTCCGGCCCCTGGT	0.597													16	319					1.99824e-07	2.67945e-07	1	0	A	35650526	A	A	35650526	3	1	199	1	0	0	0	0	1	0	0	0	14409	652	23	3	397	3	SIT1	9	35650526	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	33468338	35650526	105562905	70	36527											
FRMPD1	22844	broad.mit.edu	37	chr9	37731065	37731065	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accccctggacctcctgaaaGaagaccccgtggcctttgaa	10	7	9	15	1	0	4	0	2	0	2	1	5	1	5	7	2	0	0	7	2	3	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr9:37731065G>A	uc004aag.1	+	9	867	c.823G>A	c.(823-825)GAA>AAA	p.E275K	FRMPD1_uc004aah.1_Missense_Mutation_p.E275K|FRMPD1_uc011lqm.1_Missense_Mutation_p.E97K|FRMPD1_uc011lqn.1_Missense_Mutation_p.E144K	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	275	FERM.					cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CCTCCTGAAAGAAGACCCCGT	0.517													35	244					0	0	0	0	A	37731065	A	A	37731065	3	1	199	1	0	0	0	0	1	0	0	0	6091	943	33	2	853	2	FRMPD1	9	37731065	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	2080539	37731065	103482366	71	36528											
VPS13A	23230	broad.mit.edu	37	chr9	79824394	79824394	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaaattagttacacagatCataaaaaatcttcaggtgaa	20	10	6	5	0	3	2	2	1	1	1	3	3	3	2	0	1	1	1	0	1	8	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr9:79824394C>T	uc004akr.2	+	6	701	c.441C>T	c.(439-441)ATC>ATT	p.I147I	VPS13A_uc004akp.3_Silent_p.I147I|VPS13A_uc004akq.3_Silent_p.I147I|VPS13A_uc004aks.2_Silent_p.I147I	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	147					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						TTACACAGATCATAAAAAATC	0.254													7	19					0	0	0	0	T	79824394	T	T	79824394	2	4	199	1	0	0	0	0	0	0	0	1	17257	816	29	2		2	VPS13A	9	79824394	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	42093329	79824394	61389037	72	36529											
TLE4	7091	broad.mit.edu	37	chr9	82187743	82187743	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagatgtacccgcagaccaGacacccagtgagtgcgggcg	11	4	13	13	3	0	4	0	1	0	3	0	4	0	4	3	1	2	2	3	1	2	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr9:82187743G>A	uc004ald.2	+	1	866	c.17G>A	c.(16-18)AGA>AAA	p.R6K	TLE4_uc004alc.2_Missense_Mutation_p.R13K|TLE4_uc010mpr.2_5'UTR|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Missense_Mutation_p.R6K|TLE4_uc010mps.2_Missense_Mutation_p.R6K|TLE4_uc004alf.2_5'Flank	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CCGCAGACCAGACACCCAGTG	0.537													8	41					0	0	0	0	A	82187743	A	A	82187743	3	1	199	1	0	0	0	0	1	0	0	0	16007	942	33	2	40	2	TLE4	9	82187743	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	2363349	82187743	59025688	73	36530											
PTCH1	5727	broad.mit.edu	37	chr9	98218642	98218642	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acggcactgagcttgattccGatgaggcccatcatgccgaa	10	8	11	12	3	1	3	1	3	0	0	2	5	2	3	3	2	2	2	3	2	1	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr9:98218642G>A	uc004avk.3	-	19	3410	c.3222C>T	c.(3220-3222)ATC>ATT	p.I1074I	PTCH1_uc010mro.2_Silent_p.I923I|PTCH1_uc010mrp.2_Silent_p.I923I|PTCH1_uc010mrq.2_Silent_p.I923I|PTCH1_uc004avl.3_Silent_p.I923I|PTCH1_uc010mrr.2_Silent_p.I1008I|PTCH1_uc004avm.3_Silent_p.I1073I	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1074	Helical; (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.V1057_L1102del(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GCTTGATTCCGATGAGGCCCA	0.587									Basal_Cell_Nevus_syndrome				29	36					0	0	0	0	A	98218642	A	A	98218642	2	1	199	1	0	0	0	0	0	0	0	1	12792	1048	37	1		1	PTCH1	9	98218642	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	16030899	98218642	42994789	74	36531											
TBC1D13	54662	broad.mit.edu	37	chr9	131566365	131566365	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaaggtttactccaccttGaaagataaggatgtggagct	13	10	12	6	0	0	3	0	1	0	2	1	6	1	5	2	3	2	2	2	3	4	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr9:131566365G>C	uc010myj.2	+	9	1008	c.885G>C	c.(883-885)TTG>TTC	p.L295F	TBC1D13_uc010myk.2_Intron|TBC1D13_uc010myl.2_Missense_Mutation_p.L114F	NM_018201	NP_060671	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	295	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0						ACTCCACCTTGAAAGATAAGG	0.537													15	60					0	0	0	0	C	131566365	C	C	131566365	3	2	199	1	0	0	0	0	1	0	0	0	15668	1281	45	2	919	2	TBC1D13	9	131566365	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	33347723	131566365	9647066	75	36532											
BAT2L1	84726	broad.mit.edu	37	chr9	134305461	134305461	+	5'Flank	DEL	C	-	-																															ctctctctttttttttttttCttctctatttcaaaggcaga																										TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr9:134305461delC	uc004can.3	+						BAT2L1_uc004cam.1_Intron	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like								protein binding				0						ttttttttttcttCTCTATTT	0.378													---	---	---								-	134305461	-	-	134305461	6	5	199	0	1	1	0	1	0	0	0	0	1322	928	32	0		0	BAT2L1	9	134305461	5'Flank	DEL	C	TCGA-CV-6940-01A-11D-1912-08	2739096	134305461	6907970	76	36533											
GTF3C4	9329	broad.mit.edu	37	chr9	135554462	135554462	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggatagcagtgagcccctgcGgtgcatacctggccatcatc	8	8	12	13	1	1	1	1	1	0	0	2	2	1	2	4	3	5	2	4	3	2	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr9:135554462G>T	uc010mzv.2	+	2	1714	c.1456G>T	c.(1456-1458)GGT>TGT	p.G486C	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	486					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GAGCCCCTGCGGTGCATACCT	0.468													15	76					7.93312e-07	1.05775e-06	1	0	T	135554462	T	T	135554462	3	4	199	1	0	0	0	0	1	0	0	0	6914	1116	39	3	1462	3	GTF3C4	9	135554462	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	1249001	135554462	5658969	77	36534											
MAPK8	5599	broad.mit.edu	37	chr10	49634078	49634079	+	Frame_Shift_Del	DEL	TT	-	-																															gaaactcttccctgatgtccTtttcccagctgactcagaac																										TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr10:49634078_49634079delTT	uc009xnz.2	+	8	1060_1061	c.836_837delTT	c.(835-837)CTTfs	p.L279fs	MAPK8_uc001jgl.2_Frame_Shift_Del_p.L279fs|MAPK8_uc001jgm.2_Frame_Shift_Del_p.L279fs|MAPK8_uc001jgo.2_Frame_Shift_Del_p.L279fs|MAPK8_uc009xoa.2_Intron|MAPK8_uc001jgn.2_Frame_Shift_Del_p.L279fs|MAPK8_uc010qgk.1_Frame_Shift_Del_p.L279fs|MAPK8_uc001jgp.2_Frame_Shift_Del_p.L279fs|MAPK8_uc001jgq.2_Frame_Shift_Del_p.L279fs	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	279	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		CCTGATGTCCTTTTCCCAGCTG	0.386													---	---	---								-	49634079	-	-	49634078	7	5	199	1	0	1	0	1	0	0	0	0	9336	1609	56	0	938	0	MAPK8	10	49634078	Frame_Shift_Del	DEL	TT	TCGA-CV-6940-01A-11D-1912-08		49634078	85900669	78	36535											
ERCC6	2074	broad.mit.edu	37	chr10	50678260	50678260	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcttttccaaaacataaTcgtcattgctctgttccttg	11	15	5	10	1	2	0	1	0	1	0	5	0	4	0	2	0	3	3	2	0	4	6			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr10:50678260T>A	uc001jhs.3	-	18	3900	c.3746A>T	c.(3745-3747)GAT>GTT	p.D1249V	ERCC6_uc009xod.2_Missense_Mutation_p.D409V|ERCC6_uc010qgr.1_Missense_Mutation_p.D619V|ERCC6_uc001jhr.3_Missense_Mutation_p.D617V	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1249					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						CAAAACATAATCGTCATTGCT	0.408								Direct_reversal_of_damage|NER					113	89					0	0	0	0	A	50678260	A	A	50678260	3	1	199	1	0	0	0	0	1	0	0	0	5241	1435	50	5	751	5	ERCC6	10	50678260	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08	1044182	50678260	84856487	79	36536											
UNC5B	219699	broad.mit.edu	37	chr10	73050851	73050851	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtttccaccccgtcaactttAagacggcaaggcccagtaag	11	8	9	13	2	1	1	1	0	0	1	2	1	2	1	4	2	1	3	4	2	4	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr10:73050851A>C	uc001jro.2	+	9	1724	c.1279A>C	c.(1279-1281)AAG>CAG	p.K427Q	UNC5B_uc001jrp.2_Missense_Mutation_p.K416Q	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	427	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						CGTCAACTTTAAGACGGCAAG	0.607													19	178					0	0	0	0	C	73050851	C	C	73050851	3	2	199	1	0	0	0	0	1	0	0	0	17060	363	13	5	1313	5	UNC5B	10	73050851	Missense_Mutation	SNP	A	TCGA-CV-6940-01A-11D-1912-08	22372591	73050851	62483896	80	36537											
CYP2E1	1571	broad.mit.edu	37	chr10	135347301	135347301	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtacacaatggacggtatCaccgtgactgtggccgacct	9	10	11	11	3	1	1	1	1	0	0	1	3	1	2	3	3	1	2	3	3	3	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr10:135347301C>G	uc001lnj.1	+	6	900	c.867C>G	c.(865-867)ATC>ATG	p.I289M	CYP2E1_uc001lnk.1_Missense_Mutation_p.I152M|CYP2E1_uc009ybl.1_Missense_Mutation_p.I90M|CYP2E1_uc009ybm.1_Intron|CYP2E1_uc001lnl.1_Missense_Mutation_p.I90M	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	289					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	TGGACGGTATCACCGTGACTG	0.527									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				29	130					0	0	0	0	G	135347301	G	G	135347301	3	3	199	1	0	0	0	0	1	0	0	0	4187	816	29	2	889	2	CYP2E1	10	135347301	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	62296450	135347301	187446	81	36538											
FRG2B	441581	broad.mit.edu	37	chr10	135438868	135438868	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tctgctgtgcccacacctggGctaggtcttgataaacagcc	8	10	10	13	0	2	1	0	1	2	0	2	1	2	1	3	2	4	2	3	2	3	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr10:135438868G>A	uc010qvg.1	-	4	625	c.572C>T	c.(571-573)GCC>GTC	p.A191V		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	191						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CCACACCTGGGCTAGGTCTTG	0.572													10	101					0	0	0	0	A	135438868	A	A	135438868	3	1	199	1	0	0	0	0	1	0	0	0	6081	1203	42	4	267	4	FRG2B	10	135438868	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	91567	135438868	95879	82	36539											
PDHX	8050	broad.mit.edu	37	chr11	34988327	34988327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatccccggcctgtgatccCaccagtatcaactcctggac	8	10	7	16	1	1	1	1	1	0	0	4	2	4	2	6	2	1	1	6	2	3	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr11:34988327C>T	uc001mvt.2	+	6	1308	c.782C>T	c.(781-783)CCA>CTA	p.P261L	PDHX_uc010rep.1_Missense_Mutation_p.P246L|PDHX_uc010req.1_Intron	NM_003477	NP_003468	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	261					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			kidney(1)	1	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			CCTGTGATCCCACCAGTATCA	0.438													24	41					0	0	0	0	T	34988327	T	T	34988327	3	4	199	1	0	0	0	0	1	0	0	0	11721	594	21	4	923	4	PDHX	11	34988327	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08		34988327	100018189	83	36540											
OR4C46	119749	broad.mit.edu	37	chr11	51516007	51516007	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccacctgtgtctcccacatCacggttgtcatcttattctt	6	16	5	14	1	5	0	2	0	3	0	7	0	6	0	3	1	0	1	3	1	1	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr11:51516007C>T	uc010ric.1	+	1	726	c.726C>T	c.(724-726)ATC>ATT	p.I242I		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCTCCCACATCACGGTTGTCA	0.468													23	45					0	0	0	0	T	51516007	T	T	51516007	2	4	199	1	0	0	0	0	0	0	0	1	11105	816	29	2		2	OR4C46	11	51516007	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	16527680	51516007	83490509	84	36541											
FKBP2	2286	broad.mit.edu	37	chr11	64009862	64009862	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgtgcccacagagacatGaggctgagctggttccgggt	7	9	15	10	1	1	3	0	2	1	1	2	4	2	3	2	3	2	3	2	3	0	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr11:64009862G>T	uc001nyy.2	+	2	199	c.3G>T	c.(1-3)ATG>ATT	p.M1I	FKBP2_uc010rnh.1_Missense_Mutation_p.M1I|FKBP2_uc001nyz.2_Missense_Mutation_p.M1I	NM_004470	NP_004461	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa precursor	1					protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding				0						ACAGAGACATGAGGCTGAGCT	0.647													14	104					3.45872e-05	4.5601e-05	1	0	T	64009862	T	T	64009862	3	4	199	1	0	0	0	0	1	0	0	0	5940	1290	45	2	5	2	FKBP2	11	64009862	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	12493855	64009862	70996654	85	36542											
FKBP2	2286	broad.mit.edu	37	chr11	64011493	64011493	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaaatagagcgacgaactGagctgtaaccagactgggga	15	6	12	8	2	1	3	1	1	0	2	1	6	1	4	1	2	4	2	1	2	5	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr11:64011493G>C	uc001nyy.2	+	6	617	c.421G>C	c.(421-423)GAG>CAG	p.E141Q	FKBP2_uc010rnh.1_Missense_Mutation_p.E141Q|FKBP2_uc001nyz.2_Missense_Mutation_p.E141Q	NM_004470	NP_004461	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa precursor	141	Prevents secretion from ER (Potential).				protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding				0						GCGACGAACTGAGCTGTAACC	0.488													16	136					0	0	0	0	C	64011493	C	C	64011493	3	2	199	1	0	0	0	0	1	0	0	0	5940	1291	45	2	439	2	FKBP2	11	64011493	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	1631	64011493	70995023	86	36543											
NRXN2	9379	broad.mit.edu	37	chr11	64390422	64390422	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgcacattggggtcgctctCggcggccagcgccagcacct	5	6	13	17	5	1	0	0	0	1	0	3	0	1	0	4	4	2	3	4	4	0	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr11:64390422C>T	uc001oap.2	-	6	1349	c.838G>A	c.(838-840)GAG>AAG	p.E280K	NRXN2_uc001oar.2_Missense_Mutation_p.E1326K|NRXN2_uc001oas.2_Missense_Mutation_p.E1256K|NRXN2_uc001oao.2_5'UTR|NRXN2_uc001oaq.2_Missense_Mutation_p.E993K	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	280	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GGGTCGCTCTCGGCGGCCAGC	0.706													19	5					0	0	0	0	T	64390422	T	T	64390422	3	4	199	1	0	0	0	0	1	0	0	0	10720	893	31	1	1174	1	NRXN2	11	64390422	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	378929	64390422	70616094	87	36544											
NRXN2	9379	broad.mit.edu	37	chr11	64457916	64457916	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgccggctcctcctctccCggcccccccctcggagaaca	5	6	8	22	4	1	1	0	0	1	1	6	2	3	1	8	3	1	1	8	3	1	0	rs138744105		TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr11:64457916C>A	uc001oar.2	-	6	1250	c.811G>T	c.(811-813)GGG>TGG	p.G271W	NRXN2_uc001oas.2_Intron|NRXN2_uc001oaq.2_5'UTR	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CCTCCTCTCCCGGCCCCCCCC	0.642													8	47					0.000442599	0.000564613	1	0	A	64457916	A	A	64457916	3	1	199	1	0	0	0	0	1	0	0	0	10720	652	23	3	4672	3	NRXN2	11	64457916	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	67494	64457916	70548600	88	36545											
DHCR7	1717	broad.mit.edu	37	chr11	71148918	71148918	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcccaggtaccacccgaaGtggtcatggcagatgtcaat	11	7	11	12	1	2	1	2	0	0	1	2	2	2	1	3	3	2	2	3	3	3	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr11:71148918G>A	uc001oqk.2	-	8	1153	c.903C>T	c.(901-903)CAC>CAT	p.H301H	DHCR7_uc001oql.2_Silent_p.H301H	NM_001163817	NP_001157289	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	301					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			ovary(1)|liver(1)	2					NADH(DB00157)	ACCACCCGAAGTGGTCATGGC	0.582									Smith-Lemli-Opitz_syndrome				12	93					0	0	0	0	A	71148918	A	A	71148918	2	1	199	1	0	0	0	0	0	0	0	1	4499	1020	36	4		4	DHCR7	11	71148918	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	6691002	71148918	63857598	89	36546											
MMP1	4312	broad.mit.edu	37	chr11	102663445	102663445	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgagctcaacttccgggtaGaagggatttgtgcgcatgta	9	12	13	7	2	1	2	1	1	0	1	2	3	2	3	1	2	3	4	1	2	4	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr11:102663445G>C	uc001phi.2	-	7	1067	c.924C>G	c.(922-924)TTC>TTG	p.F308L	uc001phh.1_Intron|MMP1_uc010ruv.1_Missense_Mutation_p.F242L	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	308	Hemopexin-like 1.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		CTTCCGGGTAGAAGGGATTTG	0.433													17	41					0	0	0	0	C	102663445	C	C	102663445	3	2	199	1	0	0	0	0	1	0	0	0	9701	933	33	2	501	2	MMP1	11	102663445	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	31514527	102663445	32343071	90	36547											
PPHLN1	51535	broad.mit.edu	37	chr12	42792759	42792759	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtcagctaaccactcgctCtaaagcaatagcatcaaaaa	17	8	5	11	1	3	0	2	0	1	0	4	0	3	0	1	0	4	4	1	0	8	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr12:42792759C>G	uc001rng.1	+	9	977	c.872C>G	c.(871-873)TCT>TGT	p.S291C	PPHLN1_uc001rmy.2_Missense_Mutation_p.S309C|PPHLN1_uc001rna.2_Missense_Mutation_p.S243C|PPHLN1_uc001rne.2_Missense_Mutation_p.S279C|PPHLN1_uc001rnb.2_Missense_Mutation_p.S298C|PPHLN1_uc001rnd.2_Missense_Mutation_p.S243C|PPHLN1_uc001rnc.2_Missense_Mutation_p.S291C|PPHLN1_uc001rnf.2_Missense_Mutation_p.S272C|PPHLN1_uc010skq.1_Missense_Mutation_p.S217C|PPHLN1_uc010skr.1_Missense_Mutation_p.S236C|PPHLN1_uc010sks.1_Missense_Mutation_p.S217C|PPHLN1_uc010skt.1_Missense_Mutation_p.S171C|PPHLN1_uc001rni.1_Missense_Mutation_p.S236C|PPHLN1_uc001rnh.1_RNA|PPHLN1_uc010sku.1_Missense_Mutation_p.S224C|PPHLN1_uc001rnj.2_Missense_Mutation_p.S107C	NM_016488	NP_057572	Q8NEY8	PPHLN_HUMAN	periphilin 1 isoform 1	291					keratinization	cytoplasm|nucleus				ovary(1)|breast(1)	2	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		ACCACTCGCTCTAAAGCAATA	0.393													21	43					0	0	0	0	G	42792759	G	G	42792759	3	3	199	1	0	0	0	0	1	0	0	0	12370	913	32	2	927	2	PPHLN1	12	42792759	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08		42792759	91059136	91	36548											
NELL2	4753	broad.mit.edu	37	chr12	44913891	44913891	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagtcttggtgatgtcattgCggatggtgtcagcctggcaa	8	12	14	7	1	3	1	2	1	1	0	3	2	3	2	1	4	2	1	1	4	2	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr12:44913891C>G	uc001rog.2	-	19	2892	c.2297G>C	c.(2296-2298)CGC>CCC	p.R766P	NELL2_uc001rof.3_Missense_Mutation_p.R765P|NELL2_uc001roh.2_Missense_Mutation_p.R766P|NELL2_uc009zkd.2_Missense_Mutation_p.R718P|NELL2_uc010skz.1_Missense_Mutation_p.R816P|NELL2_uc010sla.1_Missense_Mutation_p.R789P	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	766	VWFC 5.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GATGTCATTGCGGATGGTGTC	0.552													10	74					0	0	0	0	G	44913891	G	G	44913891	3	3	199	1	0	0	0	0	1	0	0	0	10388	768	27	3	161	3	NELL2	12	44913891	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	2121132	44913891	88938004	92	36549											
KRT5	3852	broad.mit.edu	37	chr12	52912854	52912854	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtactgctcgaacaacggctCcaggttctgcctcacagtct	8	10	9	14	2	3	0	1	0	2	0	5	1	4	0	2	2	5	4	2	2	3	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr12:52912854C>A	uc001san.2	-	2	809	c.646G>T	c.(646-648)GAG>TAG	p.E216*	KRT5_uc009zmh.2_Nonsense_Mutation_p.E216*	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	216	Rod.|Linker 1.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		AACAACGGCTCCAGGTTCTGC	0.602													43	77					4.16155e-14	5.88099e-14	1	0	A	52912854	A	A	52912854	4	1	199	1	0	0	0	0	0	1	0	0	8518	864	30	2	1158	2	KRT5	12	52912854	Nonsense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	7998963	52912854	80939041	93	36550											
ITGA7	3679	broad.mit.edu	37	chr12	56087845	56087845	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgcccacatcccgctcaGactgcatggctctctcgccc	5	9	8	19	2	2	1	1	0	1	1	5	1	3	1	3	1	3	4	3	1	0	0			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr12:56087845G>A	uc001shh.2	-	19	2727	c.2507C>T	c.(2506-2508)TCT>TTT	p.S836F	ITGA7_uc001shg.2_Missense_Mutation_p.S832F|ITGA7_uc010sps.1_Missense_Mutation_p.S739F|ITGA7_uc009znw.2_Missense_Mutation_p.S79F|ITGA7_uc009znx.2_Missense_Mutation_p.S713F	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	876	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						ATCCCGCTCAGACTGCATGGC	0.592													4	21					0	0	0	0	A	56087845	A	A	56087845	3	1	199	1	0	0	0	0	1	0	0	0	7920	942	33	2	946	2	ITGA7	12	56087845	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	3174991	56087845	77764050	94	36551											
MYO1H	283446	broad.mit.edu	37	chr12	109863801	109863801	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccttctagaaaccctcatCtctaaggagccctcctacat	11	10	5	15	0	3	1	1	0	2	1	5	2	4	2	4	1	4	0	4	1	4	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr12:109863801C>G	uc010sxn.1	+	17	1728	c.1728C>G	c.(1726-1728)ATC>ATG	p.I576M		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						AAACCCTCATCTCTAAGGAGC	0.408													12	38					0	0	0	0	G	109863801	G	G	109863801	3	3	199	1	0	0	0	0	1	0	0	0	10128	903	32	2	1794	2	MYO1H	12	109863801	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	53775956	109863801	23988094	95	36552											
VPS33A	65082	broad.mit.edu	37	chr12	122723220	122723220	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggcaaactagtcttaacaCcttgatcaacgagtgctttt	12	12	8	9	1	2	1	1	1	1	0	2	3	2	1	1	1	4	2	1	1	4	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr12:122723220C>A	uc001ucd.2	-	10	1329	c.1216G>T	c.(1216-1218)GTG>TTG	p.V406L	VPS33A_uc001ucc.2_RNA	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	406					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		AGTCTTAACACCTTGATCAAC	0.308													61	124					3.13765e-25	4.5709e-25	1	0	A	122723220	A	A	122723220	3	1	199	1	0	0	0	0	1	0	0	0	17269	507	18	4	590	4	VPS33A	12	122723220	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	12859419	122723220	11128675	96	36553											
EIF2B1	1967	broad.mit.edu	37	chr12	124107222	124107222	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttgctggtttagtggaaaGagccggacaaacttgaaact	12	11	11	7	1	1	2	0	1	1	1	1	4	1	4	1	3	4	2	1	3	4	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr12:124107222G>A	uc001ufm.2	-	8	857	c.714C>T	c.(712-714)CTC>CTT	p.L238L	EIF2B1_uc001ufn.2_Silent_p.L236L	NM_001414	NP_001405	Q14232	EI2BA_HUMAN	eukaryotic translation initiation factor 2B,	238					cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)		TTAGTGGAAAGAGCCGGACAA	0.418													16	79					0	0	0	0	A	124107222	A	A	124107222	2	1	199	1	0	0	0	0	0	0	0	1	5022	929	33	2		2	EIF2B1	12	124107222	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	1384002	124107222	9744673	97	36554											
TMEM132D	121256	broad.mit.edu	37	chr12	130184841	130184841	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcacggcagcttctccccgGcgctgcggtcgtcccagtct	3	8	13	17	5	2	0	0	0	2	0	5	0	3	0	3	4	2	4	3	4	0	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr12:130184841G>T	uc009zyl.1	-	2	810	c.482C>A	c.(481-483)GCC>GAC	p.A161D		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	161	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CTTCTCCCCGGCGCTGCGGTC	0.642													7	24					8.12818e-05	0.000105981	1	0	T	130184841	T	T	130184841	3	4	199	1	0	0	0	0	1	0	0	0	16113	1203	42	4	2849	4	TMEM132D	12	130184841	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	6077619	130184841	3667054	98	36555											
POLE	5426	broad.mit.edu	37	chr12	133245062	133245062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccagctggtgctggatccGatggtattcgctgcgactgg	5	11	14	11	3	0	0	0	0	0	0	3	3	2	1	2	4	3	4	2	4	1	2	rs116326665	by1000genomes	TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr12:133245062G>A	uc001uks.1	-	19	2097	c.2053C>T	c.(2053-2055)CGG>TGG	p.R685W	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.R658W	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	685					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TGCTGGATCCGATGGTATTCG	0.592								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					41	85					0	0	0	0	A	133245062	A	A	133245062	3	1	199	1	0	0	0	0	1	0	0	0	12251	1057	37	1	4931	1	POLE	12	133245062	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	3060221	133245062	606833	99	36556											
MAB21L1	4081	broad.mit.edu	37	chr13	36050072	36050072	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaattcggtgggggagatGacctcgaggccctcgtagcg	8	8	15	10	4	1	2	1	1	0	1	4	4	1	2	2	4	1	1	2	4	2	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr13:36050072G>A	uc001uvc.2	-	1	761	c.204C>T	c.(202-204)GTC>GTT	p.V68V	NBEA_uc001uvb.2_Intron|NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_5'Flank|NBEA_uc010teg.1_5'Flank	NM_005584	NP_005575	Q13394	MB211_HUMAN	mab-21-like protein 1	68					anatomical structure morphogenesis	nucleus				ovary(2)	2		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		TGGGGGAGATGACCTCGAGGC	0.552													24	64					0	0	0	0	A	36050072	A	A	36050072	2	1	199	1	0	0	0	0	0	0	0	1	9192	1277	45	2		2	MAB21L1	13	36050072	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08		36050072	79119806	100	36557											
RCBTB1	55213	broad.mit.edu	37	chr13	50123786	50123786	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcaatctctaccacccTgaaaagttttaagaaaaatg	15	10	7	9	0	1	2	0	1	1	1	2	2	1	2	2	1	2	3	2	1	7	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr13:50123786T>C	uc001vde.1	-	9	1116	c.855_splice	c.e9-1	p.R285_splice		NM_018191	NP_060661	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and						cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		TCTACCACCCTGAAAAGTTTT	0.502													3	60					0	0	0	0	C	50123786	C	C	50123786	5	2	199	1	0	0	0	0	0	0	1	0	13236	1594	55	5	762	5	RCBTB1	13	50123786	Splice_Site	SNP	T	TCGA-CV-6940-01A-11D-1912-08	14073714	50123786	65046092	101	36558											
PCDH20	64881	broad.mit.edu	37	chr13	61987588	61987588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cattttccgggacccacaccGagatctgggaaacagggaac	12	6	11	12	2	1	1	0	0	1	1	2	5	2	4	3	3	2	0	3	3	2	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr13:61987588G>A	uc001vid.3	-	2	1008	c.644C>T	c.(643-645)TCG>TTG	p.S215L	PCDH20_uc010thj.1_Missense_Mutation_p.S215L	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	188	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GACCCACACCGAGATCTGGGA	0.532													18	63					0	0	0	0	A	61987588	A	A	61987588	3	1	199	1	0	0	0	0	1	0	0	0	11569	1059	37	1	2215	1	PCDH20	13	61987588	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	11863802	61987588	53182290	102	36559											
DOCK9	23348	broad.mit.edu	37	chr13	99476728	99476728	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgtttggggtaatgaccCtgaaggcggtgcatccttgt	7	12	14	8	2	0	2	0	2	0	0	1	3	1	2	2	4	1	3	2	4	2	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr13:99476728C>A	uc001vnt.2	-	46	5112	c.5057G>T	c.(5056-5058)AGG>ATG	p.R1686M	DOCK9_uc001vnw.2_Missense_Mutation_p.R1685M|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.R1663M|DOCK9_uc001vnq.2_Missense_Mutation_p.R235M|DOCK9_uc001vnr.2_Missense_Mutation_p.R329M|DOCK9_uc010tin.1_Missense_Mutation_p.R306M|DOCK9_uc001vns.2_Missense_Mutation_p.R235M|DOCK9_uc010tio.1_Missense_Mutation_p.R355M|DOCK9_uc010tip.1_Missense_Mutation_p.R396M|DOCK9_uc001vnu.1_Missense_Mutation_p.R235M|DOCK9_uc010tiq.1_Missense_Mutation_p.R641M	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1686	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GGTAATGACCCTGAAGGCGGT	0.542													30	85					9.65021e-13	1.33968e-12	1	0	A	99476728	A	A	99476728	3	1	199	1	0	0	0	0	1	0	0	0	4716	681	24	4	1192	4	DOCK9	13	99476728	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	37489140	99476728	15693150	103	36560											
PCCA	5095	broad.mit.edu	37	chr13	100982841	100982841	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacataatattgcattacttCgagaggtgataatcaactca	15	12	6	8	1	2	2	2	1	0	1	3	3	2	2	0	1	3	1	0	1	5	6			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr13:100982841C>T	uc001voo.2	+	17	1494	c.1456C>T	c.(1456-1458)CGA>TGA	p.R486*	PCCA_uc010aga.2_Nonsense_Mutation_p.R460*|PCCA_uc010tiz.1_Nonsense_Mutation_p.R486*|PCCA_uc001vop.2_RNA	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	486	Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	TGCATTACTTCGAGAGGTGAT	0.323													5	31					0	0	0	0	T	100982841	T	T	100982841	4	4	199	1	0	0	0	0	0	1	0	0	11558	876	31	1	1522	1	PCCA	13	100982841	Nonsense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	1506113	100982841	14187037	104	36561											
LIG4	3981	broad.mit.edu	37	chr13	108863582	108863582	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatctgcaaaaggaacgtgaGatgcaacagtttgtgaagtt	15	10	11	5	1	1	2	0	2	1	1	1	4	1	3	0	1	4	4	0	1	6	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr13:108863582G>C	uc001vqn.2	-	2	308	c.35C>G	c.(34-36)TCT>TGT	p.S12C	LIG4_uc001vqo.2_Missense_Mutation_p.S12C|LIG4_uc010agg.1_Intron|LIG4_uc010agf.2_Missense_Mutation_p.S12C|LIG4_uc001vqp.2_Missense_Mutation_p.S12C	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	12					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					AGGAACGTGAGATGCAACAGT	0.353								NHEJ					8	24					0	0	0	0	C	108863582	C	C	108863582	3	2	199	1	0	0	0	0	1	0	0	0	8824	942	33	2	2704	2	LIG4	13	108863582	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	7880741	108863582	6306296	105	36562											
DHRS2	10202	broad.mit.edu	37	chr14	24114362	24114362	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccatccaggattggggagtCagaggactgtgcaggaatcg	10	8	15	8	1	1	1	1	0	0	1	4	5	3	5	2	5	1	1	2	5	1	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr14:24114362C>G	uc001wkt.3	+	9	1201	c.754C>G	c.(754-756)CAG>GAG	p.Q252E	DHRS2_uc001wku.3_Nonsense_Mutation_p.S248*|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Silent_p.V249V	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	Error:Variant_position_missing_in_Q13268_after_alignment					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		ATTGGGGAGTCAGAGGACTGT	0.567													33	111					0	0	0	0	G	24114362	G	G	24114362	3	3	199	1	0	0	0	0	1	0	0	0	4512	839	29	2	784	2	DHRS2	14	24114362	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08		24114362	83235178	106	36563											
C15orf24	56851	broad.mit.edu	37	chr15	34380295	34380295	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgttgaccactttaggcaGaagcacaaatatcaataaag	16	10	8	7	0	1	2	1	1	0	1	1	2	1	2	1	1	1	3	1	1	7	5	rs151160666		TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:34380295G>A	uc001zhm.2	-	4	548	c.535C>T	c.(535-537)CTG>TTG	p.L179L	C15orf24_uc001zhn.2_Silent_p.L62L	NM_020154	NP_064539	Q9NPA0	CO024_HUMAN	chromosome 15 open reading frame 24 precursor	179	Helical; (Potential).					cytoplasm|integral to membrane	carbohydrate binding|carboxypeptidase activity|purine nucleotide binding				0		all_lung(180;1.76e-08)		all cancers(64;2.02e-17)|GBM - Glioblastoma multiforme(113;2.15e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)		ACTTTAGGCAGAAGCACAAAT	0.308													3	22					0	0	0	0	A	34380295	A	A	34380295	2	1	199	1	0	0	0	0	0	0	0	1	1792	933	33	2		2	C15orf24	15	34380295	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08		34380295	68151097	107	36564											
DISP2	85455	broad.mit.edu	37	chr15	40655921	40655921	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccttccagctcttcaggacCcccaccaacaacttccaccc	9	7	3	22	0	2	0	1	0	1	0	4	1	4	1	7	1	3	1	7	1	2	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:40655921C>T	uc001zlk.1	+	2	304	c.215C>T	c.(214-216)CCC>CTC	p.P72L		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	72					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TCTTCAGGACCCCCACCAACA	0.657													36	65					0	0	0	0	T	40655921	T	T	40655921	3	4	199	1	0	0	0	0	1	0	0	0	4562	623	22	4	221	4	DISP2	15	40655921	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	6275626	40655921	61875471	108	36565											
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42132731	42132731	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttcccgcagtgaccccctCtgactgctacgtgactctct	5	11	7	18	2	2	3	0	3	2	0	4	3	3	3	4	0	2	2	4	0	1	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:42132731C>G	uc010bco.2	+	3	193	c.92C>G	c.(91-93)TCT>TGT	p.S31C	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.S262C|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.S262C|JMJD7-PLA2G4B_uc001zoq.3_5'UTR|JMJD7-PLA2G4B_uc001zor.1_5'Flank	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	31	C2.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						GTGACCCCCTCTGACTGCTAC	0.622													17	62					0	0	0	0	G	42132731	G	G	42132731	3	3	199	1	0	0	0	0	1	0	0	0	7994	913	32	2	815	2	JMJD7-PLA2G4B	15	42132731	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	1476810	42132731	60398661	109	36566			1	53		5	5	2045	N	G_C	4.292174e-10
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42132977	42132977	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttttcccctccagaatgtCatggaactgaaagtctttga	10	14	7	10	0	3	3	1	2	2	1	5	4	5	4	3	1	1	0	3	1	3	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:42132977C>T	uc010bco.2	+	4	326	c.225C>T	c.(223-225)GTC>GTT	p.V75V	JMJD7-PLA2G4B_uc001zoo.3_Silent_p.V306V|JMJD7-PLA2G4B_uc010bcn.2_Silent_p.V306V|JMJD7-PLA2G4B_uc001zoq.3_5'UTR|JMJD7-PLA2G4B_uc001zor.1_5'Flank	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	75	C2.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						TCCAGAATGTCATGGAACTGA	0.592													20	62					0	0	0	0	T	42132977	T	T	42132977	2	4	199	1	0	0	0	0	0	0	0	1	7994	813	29	2		2	JMJD7-PLA2G4B	15	42132977	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	246	42132977	60398415	110	36567			1	53		5	5	2045	N	G_C	4.292174e-10
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42133453	42133453	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccgtggcgagtggctcgtCagcaatggcgttctggtggt	5	10	17	9	4	2	0	1	0	1	0	3	2	2	0	1	5	1	3	1	5	1	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:42133453C>T	uc010bco.2	+	6	518	c.417C>T	c.(415-417)GTC>GTT	p.V139V	JMJD7-PLA2G4B_uc001zoo.3_Silent_p.V370V|JMJD7-PLA2G4B_uc010bcn.2_Silent_p.V370V|JMJD7-PLA2G4B_uc001zoq.3_5'UTR|JMJD7-PLA2G4B_uc001zor.1_5'Flank	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	139					arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						AGTGGCTCGTCAGCAATGGCG	0.667													17	85					0	0	0	0	T	42133453	T	T	42133453	2	4	199	1	0	0	0	0	0	0	0	1	7994	813	29	2		2	JMJD7-PLA2G4B	15	42133453	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	476	42133453	60397939	111	36568			1	53		5	5	2045	N	G_C	4.292174e-10
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42134763	42134763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttttcaggagcccctgatGagagtggagctgaaaaaaga	13	8	14	6	0	1	4	1	3	0	2	1	7	1	6	2	3	2	2	2	3	3	2	rs2290552	by1000genomes	TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:42134763G>A	uc010bco.2	+	10	818	c.717G>A	c.(715-717)ATG>ATA	p.M239I	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.M470I|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.M470I|JMJD7-PLA2G4B_uc001zoq.3_Intron|JMJD7-PLA2G4B_uc001zor.1_5'UTR	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	239					arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						AGCCCCTGATGAGAGTGGAGC	0.637													7	37					0	0	0	0	A	42134763	A	A	42134763	3	1	199	1	0	0	0	0	1	0	0	0	7994	1290	45	2	1468	2	JMJD7-PLA2G4B	15	42134763	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	1310	42134763	60396629	112	36569			1	53		5	5	2045	N	G_C	4.292174e-10
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42134775	42134775	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccctgatgagagtggagctGaaaaaagaagcagggtgaga	15	5	15	6	0	0	5	0	4	0	3	0	8	0	6	2	2	2	2	2	2	4	0			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:42134775G>A	uc010bco.2	+	10	830	c.729G>A	c.(727-729)CTG>CTA	p.L243L	JMJD7-PLA2G4B_uc001zoo.3_Silent_p.L474L|JMJD7-PLA2G4B_uc010bcn.2_Silent_p.L474L|JMJD7-PLA2G4B_uc001zoq.3_Intron|JMJD7-PLA2G4B_uc001zor.1_5'UTR	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	243					arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						GAGTGGAGCTGAAAAAAGAAG	0.627													7	38					0	0	0	0	A	42134775	A	A	42134775	2	1	199	1	0	0	0	0	0	0	0	1	7994	1277	45	2		2	JMJD7-PLA2G4B	15	42134775	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	12	42134775	60396617	113	36570			1	53		5	5	2045	N	G_C	4.292174e-10
WDR76	79968	broad.mit.edu	37	chr15	44158387	44158387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatgtgggatcctaaacaaGaagactgtgtcatagttggc	12	10	11	8	0	1	2	1	0	0	2	2	3	2	3	2	2	1	1	2	2	5	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:44158387G>A	uc001zti.1	+	13	1701	c.1678G>A	c.(1678-1680)GAA>AAA	p.E560K		NM_024908	NP_079184	Q9H967	WDR76_HUMAN	WD repeat domain 76	560	WD 6.										0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		TCCTAAACAAGAAGACTGTGT	0.458													16	54					0	0	0	0	A	44158387	A	A	44158387	3	1	199	1	0	0	0	0	1	0	0	0	17394	943	33	2	1728	2	WDR76	15	44158387	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	2023612	44158387	58373005	114	36571											
DUOXA2	405753	broad.mit.edu	37	chr15	45408913	45408913	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctggcgggacactacgcCtcggccacgctatggtaagt	8	7	12	14	4	0	0	0	0	0	0	1	1	0	1	3	4	1	2	3	4	3	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:45408913C>T	uc001zuo.2	+	4	820	c.540C>T	c.(538-540)GCC>GCT	p.A180A	DUOX2_uc010bea.2_5'Flank|DUOX2_uc001zun.2_5'Flank|DUOXA2_uc010beb.2_RNA	NM_207581	NP_997464	Q1HG44	DOXA2_HUMAN	dual oxidase activator 2	180	Extracellular (Potential).				protein transport	endoplasmic reticulum membrane|integral to membrane					0		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;2.88e-18)|GBM - Glioblastoma multiforme(94;3.95e-07)|COAD - Colon adenocarcinoma(120;0.0652)|Colorectal(133;0.0659)		GACACTACGCCTCGGCCACGC	0.647													7	17					0	0	0	0	T	45408913	T	T	45408913	2	4	199	1	0	0	0	0	0	0	0	1	4825	668	24	4		4	DUOXA2	15	45408913	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08	1250526	45408913	57122479	115	36572											
ITGA11	22801	broad.mit.edu	37	chr15	68605146	68605146	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagggaggcccgataccatCgtatctctccagcgagctgt	9	8	12	12	3	1	0	0	0	1	0	4	4	2	1	3	2	3	2	3	2	3	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:68605146C>T	uc002ari.2	-	24	3025	c.2938G>A	c.(2938-2940)GAT>AAT	p.D980N	ITGA11_uc010bib.2_Missense_Mutation_p.D980N	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	980	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	CCGATACCATCGTATCTCTCC	0.637													7	29					0	0	0	0	T	68605146	T	T	68605146	3	4	199	1	0	0	0	0	1	0	0	0	7913	884	31	1	656	1	ITGA11	15	68605146	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	23196233	68605146	33926246	116	36573											
OR4F4	26682	broad.mit.edu	37	chr15	102462360	102462360	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagatctaaaactttacactAgaatgtgcatcccattttct	14	14	4	9	0	2	2	0	0	2	2	3	2	3	2	1	0	3	1	1	0	6	6			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr15:102462360A>G	uc002cdf.1	-	1	903	c.903T>C	c.(901-903)TCT>TCC	p.S301S		NM_001004195	NP_001004195	Q96R69	OR4F4_HUMAN	olfactory receptor, family 4, subfamily F,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			ACTTTACACTAGAATGTGCAT	0.343													23	267					0	0	0	0	G	102462360	G	G	102462360	2	3	199	1	0	0	0	0	0	0	0	1	11118	407	15	5		5	OR4F4	15	102462360	Silent	SNP	A	TCGA-CV-6940-01A-11D-1912-08	33857214	102462360	69032	117	36574											
ARL6IP1	23204	broad.mit.edu	37	chr16	18809332	18809332	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cataacaaaacaggaaacgcCggacagaacagatggatcta	19	4	9	9	2	1	2	0	0	1	2	1	5	1	5	1	3	4	0	1	3	6	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr16:18809332C>G	uc002dfl.1	-	3	274	c.205G>C	c.(205-207)GGC>CGC	p.G69R	ARL6IP1_uc010van.1_Missense_Mutation_p.G40R|ARL6IP1_uc010bvz.1_RNA	NM_015161	NP_055976	Q15041	AR6P1_HUMAN	ADP-ribosylation factor-like 6 interacting	69	Helical; (Potential).					integral to membrane	protein binding				0						CAGGAAACGCCGGACAGAACA	0.343													7	44					0	0	0	0	G	18809332	G	G	18809332	3	3	199	1	0	0	0	0	1	0	0	0	944	652	23	3	422	3	ARL6IP1	16	18809332	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08		18809332	71545421	118	36575											
DNAH3	55567	broad.mit.edu	37	chr16	20975470	20975470	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttacccttggacatggagaGaacctccaagatcttatctt	11	12	8	10	0	2	2	0	0	2	2	3	5	3	4	3	2	2	1	3	2	4	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr16:20975470G>C	uc010vbe.1	-	53	9736	c.9736C>G	c.(9736-9738)CTC>GTC	p.L3246V	DNAH3_uc010vbd.1_Missense_Mutation_p.L681V	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3246	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GACATGGAGAGAACCTCCAAG	0.443													33	98					0	0	0	0	C	20975470	C	C	20975470	3	2	199	1	0	0	0	0	1	0	0	0	4625	942	33	2	2653	2	DNAH3	16	20975470	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	2166138	20975470	69379283	119	36576											
LONP2	83752	broad.mit.edu	37	chr16	48382183	48382183	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgactggagaaattacactGagaggtcttgttcttccagt	11	13	10	7	0	2	3	0	2	2	2	3	5	3	3	1	2	1	1	1	2	2	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr16:48382183G>C	uc002efi.1	+	14	2408	c.2319G>C	c.(2317-2319)CTG>CTC	p.L773L	LONP2_uc002efj.1_Silent_p.L729L	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	773					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						AAATTACACTGAGAGGTCTTG	0.348													31	112					0	0	0	0	C	48382183	C	C	48382183	2	2	199	1	0	0	0	0	0	0	0	1	8943	1277	45	2		2	LONP2	16	48382183	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	27406713	48382183	41972570	120	36577											
CHD9	80205	broad.mit.edu	37	chr16	53272475	53272475	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacaaatgatacagcaatacGagatgtacttcagggattca	16	9	9	7	1	2	2	2	1	0	1	2	5	2	3	0	1	4	2	0	1	5	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr16:53272475G>A	uc002ehb.2	+	11	3018	c.2854G>A	c.(2854-2856)GAG>AAG	p.E952K	CHD9_uc002egy.2_Missense_Mutation_p.E952K|CHD9_uc002eha.1_Missense_Mutation_p.E952K|CHD9_uc002ehc.2_Missense_Mutation_p.E952K|CHD9_uc002ehf.2_Missense_Mutation_p.E66K|CHD9_uc002ehd.2_Missense_Mutation_p.E478K|CHD9_uc002ehe.1_Missense_Mutation_p.E66K	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	952	Helicase ATP-binding.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				ACAGCAATACGAGATGTACTT	0.373													46	127					0	0	0	0	A	53272475	A	A	53272475	3	1	199	1	0	0	0	0	1	0	0	0	3347	1059	37	1	2896	1	CHD9	16	53272475	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	4890292	53272475	37082278	121	36578											
VPS53	55275	broad.mit.edu	37	chr17	617910	617910	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgtgagctgcagcacggcttCcagctcctccacgaactcca	8	7	9	17	3	0	1	0	1	0	0	4	2	4	1	4	1	5	5	4	1	1	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:617910C>G	uc002frn.2	-	1	187	c.40G>C	c.(40-42)GAA>CAA	p.E14Q	VPS53_uc010cjo.1_Missense_Mutation_p.E14Q|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Missense_Mutation_p.E14Q|VPS53_uc002fro.2_5'UTR|VPS53_uc010cjp.1_Missense_Mutation_p.E14Q	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	14					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		AGCACGGCTTCCAGCTCCTCC	0.701													16	99					0	0	0	0	G	617910	G	G	617910	3	3	199	1	0	0	0	0	1	0	0	0	17283	864	30	2	2561	2	VPS53	17	617910	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08		617910	80577300	122	36579											
ZNF594	84622	broad.mit.edu	37	chr17	5087253	5087253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggccactaacctcatatCtatgggagctttctcctgca	8	14	7	12	0	3	0	1	0	2	0	4	1	3	1	3	2	3	2	3	2	3	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:5087253C>T	uc010cla.1	-	2	455	c.299G>A	c.(298-300)AGA>AAA	p.R100K		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						AACCTCATATCTATGGGAGCT	0.373													12	57					0	0	0	0	T	5087253	T	T	5087253	3	4	199	1	0	0	0	0	1	0	0	0	18091	913	32	2	2128	2	ZNF594	17	5087253	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	4469343	5087253	76107957	123	36580											
TP53	7157	broad.mit.edu	37	chr17	7577102	7577119	+	In_Frame_Del	DEL	CCAGGACAGGCACAAACA	-	-																															cctctgtgcgccggtctctcCcaggacaggcacaaacacgc																								rs17849781		TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:7577102_7577119delCCAGGACAGGCACAAACA	uc002gim.2	-	8	1013_1030	c.819_836delTGTTTGTGCCTGTCCTGG	c.(817-837)CGTGTTTGTGCCTGTCCTGGG>CGG	p.VCACPG274del	TP53_uc002gig.1_Intron|TP53_uc002gih.2_In_Frame_Del_p.VCACPG274del|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.VCACPG142del|TP53_uc010cng.1_In_Frame_Del_p.VCACPG142del|TP53_uc002gii.1_In_Frame_Del_p.VCACPG142del|TP53_uc010cnh.1_In_Frame_Del_p.VCACPG274del|TP53_uc010cni.1_In_Frame_Del_p.VCACPG274del|TP53_uc002gij.2_In_Frame_Del_p.VCACPG274del	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	274_279	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> E (in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).|G -> W (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P278L(52)|p.P278S(48)|p.C275Y(44)|p.C275F(34)|p.G279E(32)|p.P278R(26)|p.P278T(21)|p.C277F(20)|p.P278A(18)|p.V274F(17)|p.C277Y(15)|p.V274A(13)|p.A276P(13)|p.P278H(11)|p.A276S(9)|p.V274L(9)|p.R280fs*65(7)|p.V274D(7)|p.A276V(7)|p.G279R(7)|p.C275G(7)|p.C275W(7)|p.0?(7)|p.A276T(7)|p.C277*(6)|p.V274G(6)|p.A276D(6)|p.C275R(6)|p.P278fs*67(5)|p.G279V(4)|p.C277G(4)|p.C275C(4)|p.C277C(4)|p.A276G(4)|p.V274I(4)|p.P278F(3)|p.V274V(3)|p.C275fs*31(2)|p.C275S(2)|p.C275fs*70(2)|p.G279W(2)|p.P278fs*28(2)|p.C277fs*29(2)|p.?(2)|p.C277W(2)|p.G279fs*65(2)|p.A276A(2)|p.G279fs*27(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274fs*71(1)|p.R273_C275delRVC(1)|p.G279_R280delGR(1)|p.R273R(1)|p.E258fs*71(1)|p.C275_A276ins10(1)|p.V274_P278del(1)|p.R280fs*62(1)|p.E271_R273delEVR(1)|p.R273S(1)|p.C275*(1)|p.G279fs*59(1)|p.C277_P278insXXXXXXX(1)|p.F270_D281del12(1)|p.P278_G279insXXXXX(1)|p.A276fs*31(1)|p.C275_R283delCACPGRDRR(1)|p.A276fs*70(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.A276_C277delAC(1)|p.C275fs*67(1)|p.C277R(1)|p.C277S(1)|p.V272_K292del21(1)|p.A276fs*68(1)|p.C275fs*20(1)|p.A276fs*29(1)|p.G279fs*26(1)|p.R273fs*71(1)|p.P278P(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTCTCTCCCAGGACAGGCACAAACACGCACCTCAA	0.541		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7577119	-	-	7577102	7	5	199	1	0	1	0	1	0	0	0	0	16448	623	22	0	450	0	TP53	17	7577102	In_Frame_Del	DEL	CCAGGACAGGCACAAACA	TCGA-CV-6940-01A-11D-1912-08	2489849	7577102	73618108	124	36581											
MYH8	4626	broad.mit.edu	37	chr17	10296300	10296300	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcctgttccttcttcagctCctcagccatcatggcagcct	5	13	7	16	0	4	0	3	0	1	0	7	0	7	0	5	1	3	3	5	1	0	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:10296300C>A	uc002gmm.2	-	37	5406	c.5311G>T	c.(5311-5313)GAG>TAG	p.E1771*	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1771	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTCTTCAGCTCCTCAGCCATC	0.483									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				36	147					6.70999e-13	9.37016e-13	1	0	A	10296300	A	A	10296300	4	1	199	1	0	0	0	0	0	1	0	0	10094	864	30	2	518	2	MYH8	17	10296300	Nonsense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	2719198	10296300	70898910	125	36582											
KIAA0100	9703	broad.mit.edu	37	chr17	26960318	26960318	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacttagaggctgttctcacGttgatatccaagtcaccctt	9	13	7	12	1	2	2	2	1	1	1	4	2	3	2	2	1	0	3	2	1	3	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:26960318G>A	uc002hbu.2	-	19	3666	c.3567C>T	c.(3565-3567)AAC>AAT	p.N1189N		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1189						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CTGTTCTCACGTTGATATCCA	0.512													26	123					0	0	0	0	A	26960318	A	A	26960318	2	1	199	1	0	0	0	0	0	0	0	1	8193	1136	40	1		1	KIAA0100	17	26960318	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	16664018	26960318	54234892	126	36583											
GPR179	440435	broad.mit.edu	37	chr17	36482452	36482452	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaggacgaagactgagactCagcttcctggagacttggct	11	9	12	9	1	1	3	1	1	0	3	2	7	2	4	1	3	1	2	1	3	2	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:36482452C>A	uc002hpz.2	-	11	7021	c.7000G>T	c.(7000-7002)GAG>TAG	p.E2334*		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	2334	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GACTGAGACTCAGCTTCCTGG	0.507													29	135					1.75199e-13	2.46112e-13	1	0	A	36482452	A	A	36482452	4	1	199	1	0	0	0	0	0	1	0	0	6712	835	29	2	107	2	GPR179	17	36482452	Nonsense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	9522134	36482452	44712758	127	36584											
DHX8	1659	broad.mit.edu	37	chr17	41584941	41584941	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtacatgacagatgggaTgttgcttagagagtgcttga	12	11	13	5	0	0	4	0	2	0	2	0	6	0	5	0	1	3	4	0	1	3	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:41584941T>C	uc002idu.1	+	14	2067	c.1994T>C	c.(1993-1995)ATG>ACG	p.M665T	DHX8_uc010wif.1_Missense_Mutation_p.M574T|DHX8_uc010wig.1_Missense_Mutation_p.M665T	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	665	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ACAGATGGGATGTTGCTTAGA	0.478													13	60					0	0	0	0	C	41584941	C	C	41584941	3	2	199	1	0	0	0	0	1	0	0	0	4537	1464	51	5	2048	5	DHX8	17	41584941	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08	5102489	41584941	39610269	128	36585											
CHAD	1101	broad.mit.edu	37	chr17	48542772	48542772	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgaggcacaggtggcatCtgggcgggaggccttggctt	6	8	19	8	1	1	1	0	1	1	0	1	2	1	2	1	8	0	3	1	8	0	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:48542772C>T	uc010dbr.2	-	3	1020	c.967G>A	c.(967-969)GAT>AAT	p.D323N	ACSF2_uc002iqu.2_Intron|ACSF2_uc010wml.1_Intron|ACSF2_uc010wmm.1_Intron|ACSF2_uc010wmn.1_Intron|ACSF2_uc010wmo.1_Intron|CHAD_uc010dbs.2_Missense_Mutation_p.D323N|ACSF2_uc010dbt.1_5'Flank	NM_001267	NP_001258	O15335	CHAD_HUMAN	chondroadherin precursor	323	LRRCT.				regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(2)|central_nervous_system(1)	3	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CAGGTGGCATCTGGGCGGGAG	0.617													12	52					0	0	0	0	T	48542772	T	T	48542772	3	4	199	1	0	0	0	0	1	0	0	0	3325	913	32	2	116	2	CHAD	17	48542772	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	6957831	48542772	32652438	129	36586											
ACE	1636	broad.mit.edu	37	chr17	61571742	61571742	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccactcgacaggctgaagtaCcagggcctctgccccccagt	8	6	10	17	1	1	1	0	1	1	0	2	2	1	1	6	2	2	2	6	2	2	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:61571742C>G	uc002jau.1	+	22	3313	c.3291C>G	c.(3289-3291)TAC>TAG	p.Y1097*	ACE_uc002jav.1_Nonsense_Mutation_p.Y523*|ACE_uc010ddv.1_Nonsense_Mutation_p.Y324*|ACE_uc010wpj.1_Nonsense_Mutation_p.Y523*|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Nonsense_Mutation_p.Y343*	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	1097	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGCTGAAGTACCAGGGCCTCT	0.552													4	45					0	0	0	0	G	61571742	G	G	61571742	4	3	199	1	0	0	0	0	0	1	0	0	136	518	18	4	3580	4	ACE	17	61571742	Nonsense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	13028970	61571742	19623468	130	36587											
SEPT9	10801	broad.mit.edu	37	chr17	75484325	75484325	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccgtggctctgtgcagataTtgaggagaaaggcgtccgga	9	9	15	8	3	1	3	0	1	1	2	3	5	3	4	2	4	1	2	2	4	2	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:75484325T>C	uc002jts.3	+	6	1172	c.1046T>C	c.(1045-1047)ATT>ACT	p.I349T	SEPT9_uc010wtk.1_Missense_Mutation_p.I330T|SEPT9_uc002jtt.3_Missense_Mutation_p.I185T|SEPT9_uc002jtu.3_Missense_Mutation_p.I331T|SEPT9_uc002jtv.2_Missense_Mutation_p.I342T|SEPT9_uc002jtw.2_Missense_Mutation_p.I185T|SEPT9_uc010wtl.1_Missense_Mutation_p.I125T|SEPT9_uc002jty.3_Missense_Mutation_p.I98T|SEPT9_uc010wtm.1_Missense_Mutation_p.I98T|SEPT9_uc010wtn.1_Missense_Mutation_p.I98T|SEPT9_uc010dhd.2_Missense_Mutation_p.I237T	NM_001113491	NP_001106963	Q9UHD8	SEPT9_HUMAN	septin 9 isoform a	349					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding|protein binding			breast(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(99;0.153)			TGTGCAGATATTGAGGAGAAA	0.612													27	42					0	0	0	0	C	75484325	C	C	75484325	3	2	199	1	0	0	0	0	1	0	0	0	14136	1493	52	5	1542	5	SEPT9	17	75484325	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08	13912583	75484325	5710885	131	36588											
TMC6	11322	broad.mit.edu	37	chr17	76113582	76113582	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acaccaggaagacaaagaagGtgttttccatcaggtaccgg	14	7	11	9	1	1	2	1	0	0	2	2	3	2	3	3	4	1	2	3	4	4	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:76113582G>A	uc002juj.1	-	16	2291	c.2165C>T	c.(2164-2166)ACC>ATC	p.T722I	TMC6_uc002jui.1_Missense_Mutation_p.T301I|TMC6_uc010dhf.1_Missense_Mutation_p.T555I|TMC6_uc002juk.2_Missense_Mutation_p.T722I|TMC6_uc010dhg.1_Intron|TMC6_uc002jul.1_Missense_Mutation_p.T722I	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	722	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GACAAAGAAGGTGTTTTCCAT	0.682									Epidermodysplasia_Verruciformis_Familial_Clustering_of				4	7					0	0	0	0	A	76113582	A	A	76113582	3	1	199	1	0	0	0	0	1	0	0	0	16055	1261	44	4	268	4	TMC6	17	76113582	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	629257	76113582	5081628	132	36589											
USP36	57602	broad.mit.edu	37	chr17	76832439	76832439	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctccttcaacttatccactaTtggcatggtgcatcactgtg	8	14	7	12	0	2	0	2	0	0	0	4	0	4	0	2	2	2	2	2	2	3	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:76832439T>C	uc002jvz.1	-	3	332	c.7A>G	c.(7-9)ATA>GTA	p.I3V	USP36_uc002jwa.1_Missense_Mutation_p.I3V|USP36_uc002jwd.1_Missense_Mutation_p.I3V	NM_025090	NP_079366	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	3					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			TTATCCACTATTGGCATGGTG	0.493													23	41					0	0	0	0	C	76832439	C	C	76832439	3	2	199	1	0	0	0	0	1	0	0	0	17135	1493	52	5	3436	5	USP36	17	76832439	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08	718857	76832439	4362771	133	36590											
CCDC57	284001	broad.mit.edu	37	chr17	80146213	80146213	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagaaccctggtctgcagctCctgcagctgctccacgtggg	6	8	12	15	1	1	1	0	0	1	1	3	1	3	1	3	2	6	5	3	2	1	0			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr17:80146213C>G	uc002kdz.1	-	8	1289	c.934G>C	c.(934-936)GAG>CAG	p.E312Q	CCDC57_uc002kdx.1_Missense_Mutation_p.E312Q	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	312	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			GTCTGCAGCTCCTGCAGCTGC	0.642													5	12					0	0	0	0	G	80146213	G	G	80146213	3	3	199	1	0	0	0	0	1	0	0	0	2840	864	30	2	1857	2	CCDC57	17	80146213	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	3313774	80146213	1048997	134	36591											
CD97	976	broad.mit.edu	37	chr19	14512333	14512333	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggatcctggccaagagcCtgcctaaaggccccttcacc	9	7	10	15	0	1	2	1	1	0	1	2	3	2	3	7	3	2	0	7	3	3	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr19:14512333C>T	uc002myl.2	+	10	1156	c.1033C>T	c.(1033-1035)CTG>TTG	p.L345L	CD97_uc002mym.2_Silent_p.L296L|CD97_uc002myn.2_Silent_p.L252L	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	345	Extracellular (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						GGCCAAGAGCCTGCCTAAAGG	0.622													7	51					0	0	0	0	T	14512333	T	T	14512333	2	4	199	1	0	0	0	0	0	0	0	1	3064	680	24	4		4	CD97	19	14512333	Silent	SNP	C	TCGA-CV-6940-01A-11D-1912-08		14512333	44616650	135	36592											
CD79A	973	broad.mit.edu	37	chr19	42383229	42383229	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccctgagttcttgggcccGggcgaggaccccaatggtac	6	7	13	15	2	1	1	0	1	1	0	1	3	1	2	5	4	1	2	5	4	2	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr19:42383229G>A	uc002orv.2	+	2	434	c.249G>A	c.(247-249)CCG>CCA	p.P83P	CD79A_uc002oru.2_Silent_p.P83P	NM_001783	NP_001774	P11912	CD79A_HUMAN	CD79A antigen isoform 1 precursor	83	Ig-like C2-type.|Extracellular (Potential).				B cell differentiation|B cell proliferation|B cell receptor signaling pathway	B cell receptor complex|external side of plasma membrane|integral to membrane|membrane raft|multivesicular body	transmembrane receptor activity			ovary(2)|pancreas(1)	3						TCTTGGGCCCGGGCGAGGACC	0.602			O|S		DLBCL								6	100					0	0	0	0	A	42383229	A	A	42383229	2	1	199	1	0	0	0	0	0	0	0	1	3051	1103	39	1		1	CD79A	19	42383229	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	27870896	42383229	16745754	136	36593											
PEG3	5178	broad.mit.edu	37	chr19	57335633	57335633	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccgtggagactctcaccttCtggttggtacatctccttgt	5	14	9	13	1	3	1	1	0	3	1	5	2	3	1	3	3	1	2	3	3	1	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr19:57335633C>T	uc002qnu.2	-	1	742	c.391G>A	c.(391-393)GAA>AAA	p.E131K	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Missense_Mutation_p.E5K|ZIM2_uc002qnq.2_Missense_Mutation_p.E5K|ZIM2_uc010etp.2_Missense_Mutation_p.E5K|ZIM2_uc010ygs.1_Missense_Mutation_p.E5K|PEG3_uc002qnt.2_Missense_Mutation_p.E131K|PEG3_uc002qnv.2_Missense_Mutation_p.E131K|PEG3_uc002qnw.2_Missense_Mutation_p.E5K|PEG3_uc002qnx.2_Missense_Mutation_p.E5K|PEG3_uc010etr.2_Missense_Mutation_p.E131K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	131					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTCTCACCTTCTGGTTGGTAC	0.423													14	102					0	0	0	0	T	57335633	T	T	57335633	3	4	199	1	0	0	0	0	1	0	0	0	11774	922	32	2		2	PEG3	19	57335633	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	14952404	57335633	1793350	137	36594											
DEFB127	140850	broad.mit.edu	37	chr20	139650	139650	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaatttcccaagcctgaaGacacagtctacataaatcaa	18	8	5	10	0	2	2	1	1	1	1	3	3	3	2	2	0	2	0	2	0	8	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr20:139650G>A	uc002wcy.1	+	2	285	c.285G>A	c.(283-285)AAG>AAA	p.K95K		NM_139074	NP_620713	Q9H1M4	DB127_HUMAN	defensin, beta 127 preproprotein	95					defense response to bacterium|innate immune response	extracellular region					0		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			CAAGCCTGAAGACACAGTCTA	0.353													8	30					0	0	0	0	A	139650	A	A	139650	2	1	199	1	0	0	0	0	0	0	0	1	4434	933	33	2		2	DEFB127	20	139650	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08		139650	62885870	138	36595											
GFRA4	64096	broad.mit.edu	37	chr20	3644019	3644019	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acccagtaacagcagcagcaGcagcgcaggccccaggcagc	12	1	12	16	1	0	0	0	0	0	0	0	0	0	0	3	2	7	7	3	2	1	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr20:3644019G>A	uc002wio.2	-	1	28	c.28C>T	c.(28-30)CTG>TTG	p.L10L	GFRA4_uc002win.2_Silent_p.L10L|GFRA4_uc002wip.1_Silent_p.L10L	NM_145762	NP_665705	Q9GZZ7	GFRA4_HUMAN	GDNF family receptor alpha 4 isoform b	10						anchored to membrane|extracellular region|plasma membrane	receptor activity				0						AGCAGCAGCAGCAGCGCAGGC	0.637													9	12					0	0	0	0	A	3644019	A	A	3644019	2	1	199	1	0	0	0	0	0	0	0	1	6387	962	34	4		4	GFRA4	20	3644019	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	3504369	3644019	59381501	139	36596											
C20orf3	57136	broad.mit.edu	37	chr20	24944531	24944531	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccatcgtgttcgtgcaccTcgctgatgtaggtggccacc	5	10	12	14	3	0	1	0	1	0	0	3	1	0	1	4	2	1	4	4	2	1	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr20:24944531T>G	uc002wty.2	-	9	1270	c.1169A>C	c.(1168-1170)GAG>GCG	p.E390A	C20orf3_uc002wtz.2_Missense_Mutation_p.E398A|C20orf3_uc010zsw.1_3'UTR	NM_020531	NP_065392	Q9HDC9	APMAP_HUMAN	chromosome 20 open reading frame 3	390	Extracellular (Potential).				biosynthetic process	cell surface|integral to membrane	arylesterase activity|strictosidine synthase activity			ovary(1)	1						TTCGTGCACCTCGCTGATGTA	0.612													52	57					0	0	0	0	G	24944531	G	G	24944531	3	3	199	1	0	0	0	0	1	0	0	0	2119	1551	54	5	85	5	C20orf3	20	24944531	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08	21300512	24944531	38080989	140	36597											
GDF5	8200	broad.mit.edu	37	chr20	34022225	34022225	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctgccgggcggcgcggtCgaagcccaggccacggaggt	6	3	18	14	6	0	0	0	0	0	0	1	3	0	1	4	6	2	0	4	6	1	0			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr20:34022225C>A	uc002xck.1	-	2	1307	c.988G>T	c.(988-990)GAC>TAC	p.D330Y	GDF5_uc010gfc.1_Missense_Mutation_p.D330Y|uc002xcj.2_Silent_p.V212V|GDF5_uc010zvc.1_Missense_Mutation_p.D330Y	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	330					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GCGGCGCGGTCGAAGCCCAGG	0.632													4	37					0.00024832	0.000320238	1	0	A	34022225	A	A	34022225	3	1	199	1	0	0	0	0	1	0	0	0	6353	884	31	3	521	3	GDF5	20	34022225	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	9077694	34022225	29003295	141	36598											
GDF5	8200	broad.mit.edu	37	chr20	34025402	34025402	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctggcttgggttcagggcCgcccggtctggggggcagct	2	9	18	12	2	2	0	1	0	1	0	3	0	3	0	3	7	1	4	3	7	0	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr20:34025402C>T	uc002xck.1	-	1	626	c.307G>A	c.(307-309)GGC>AGC	p.G103S	GDF5_uc010gfc.1_Missense_Mutation_p.G103S|GDF5_uc010zvc.1_Missense_Mutation_p.G103S	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	103					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GGTTCAGGGCCGCCCGGTCTG	0.632													29	46					0	0	0	0	T	34025402	T	T	34025402	3	4	199	1	0	0	0	0	1	0	0	0	6353	652	23	1	1206	1	GDF5	20	34025402	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	3177	34025402	29000118	142	36599											
ZNFX1	57169	broad.mit.edu	37	chr20	47870298	47870298	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccgcagcttcttccactaTgacaatcctcggctccacct	7	12	5	17	2	1	1	0	1	1	0	6	1	5	1	5	1	1	3	5	1	2	4			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr20:47870298T>A	uc002xui.2	-	11	3257	c.3010A>T	c.(3010-3012)ATA>TTA	p.I1004L		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1004							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCTTCCACTATGACAATCCTC	0.527													109	213					0	0	0	0	A	47870298	A	A	47870298	3	1	199	1	0	0	0	0	1	0	0	0	18272	1464	51	5	2762	5	ZNFX1	20	47870298	Missense_Mutation	SNP	T	TCGA-CV-6940-01A-11D-1912-08	13844896	47870298	15155222	143	36600											
RBM38	55544	broad.mit.edu	37	chr20	55982844	55982844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctcagccgcagcacccgCgggcaccactttcgtgcagt	6	7	10	18	4	1	0	1	0	1	0	3	0	1	0	4	1	3	4	4	1	0	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr20:55982844C>T	uc010zzj.1	+	4	837	c.662C>T	c.(661-663)GCG>GTG	p.A221V	RBM38_uc010zzk.1_3'UTR	NM_017495	NP_059965	Q9H0Z9	RBM38_HUMAN	RNA-binding region containing protein 1 isoform	221					3'-UTR-mediated mRNA stabilization|cell cycle|cell cycle arrest|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mRNA processing|negative regulation of cell proliferation|regulation of RNA splicing|RNA splicing	cytosol|cytosol|nucleus|nucleus	mRNA 3'-UTR binding|mRNA binding|nucleotide binding|RNA binding				0	Lung NSC(12;0.00242)|all_lung(29;0.00767)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.55e-12)|Epithelial(14;9.49e-09)|all cancers(14;5.01e-08)			GCAGCACCCGCGGGCACCACT	0.682													3	10					0	0	0	0	T	55982844	T	T	55982844	3	4	199	1	0	0	0	0	1	0	0	0	13197	768	27	1	435	1	RBM38	20	55982844	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	8112546	55982844	7042676	144	36601											
C2CD2	25966	broad.mit.edu	37	chr21	43338269	43338269	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaccactgatggagaggcaGaaccagccaaatgcttcaag	15	5	11	10	0	1	3	1	1	0	2	1	5	1	3	3	2	4	2	3	2	4	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr21:43338269G>C	uc002yzw.2	-	5	907	c.665C>G	c.(664-666)TCT>TGT	p.S222C	C2CD2_uc002yzu.2_Missense_Mutation_p.S54C|C2CD2_uc002yzv.2_Missense_Mutation_p.S67C|C2CD2_uc002yzx.1_Missense_Mutation_p.S67C	NM_015500	NP_056315	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2 isoform	222						cytosol|extracellular region|nucleus				ovary(1)	1						TGGAGAGGCAGAACCAGCCAA	0.512													31	46					0	0	0	0	C	43338269	C	C	43338269	3	2	199	1	0	0	0	0	1	0	0	0	2162	942	33	2	1465	2	C2CD2	21	43338269	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08		43338269	4791626	145	36602											
C21orf58	54058	broad.mit.edu	37	chr21	47737162	47737162	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaggtcccccttccacgttCtgccgttcttgctccagctt	3	14	7	17	2	3	0	1	0	2	0	6	0	6	0	5	1	3	4	5	1	0	5			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr21:47737162C>G	uc002zjf.2	-	4	1464	c.330G>C	c.(328-330)CAG>CAC	p.Q110H	C21orf58_uc002ziz.2_Missense_Mutation_p.Q27H|C21orf58_uc002zja.2_5'UTR|C21orf58_uc011afw.1_Missense_Mutation_p.Q27H|C21orf58_uc002zjc.2_5'UTR|C21orf58_uc011afx.1_5'UTR|C21orf58_uc010gqj.1_RNA|C21orf58_uc002zjg.1_RNA	NM_058180	NP_478060	P58505	CU058_HUMAN	hypothetical protein LOC54058	110										pancreas(1)	1	Breast(49;0.112)			Colorectal(79;0.239)		CTTCCACGTTCTGCCGTTCTT	0.602													6	12					0	0	0	0	G	47737162	G	G	47737162	3	3	199	1	0	0	0	0	1	0	0	0	2139	912	32	2	662	2	C21orf58	21	47737162	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	4398893	47737162	392733	146	36603											
PEX26	55670	broad.mit.edu	37	chr22	18570779	18570779	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcctctacaagctggcccagCtcttccgctggatccggaag	7	9	10	15	2	2	0	0	0	2	0	5	2	5	2	4	3	3	3	4	3	3	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr22:18570779C>T	uc002znp.3	+	6	1065	c.856C>T	c.(856-858)CTC>TTC	p.L286F	TUBA8_uc002znr.2_Intron|PEX26_uc002znq.3_Missense_Mutation_p.L286F|PEX26_uc002znt.2_Missense_Mutation_p.L237F	NM_017929	NP_060399	Q7Z412	PEX26_HUMAN	peroxisome biogenesis factor 26	286	Peroxisomal matrix (Potential).				protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			skin(1)	1						GCTGGCCCAGCTCTTCCGCTG	0.617													98	192					0	0	0	0	T	18570779	T	T	18570779	3	4	199	1	0	0	0	0	1	0	0	0	11801	797	28	4	874	4	PEX26	22	18570779	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08		18570779	32733787	147	36604											
GSTT1	2952	broad.mit.edu	37	chr22	24379500	24379500	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgcgcgtcaggtagagcAggatggccacactgtgggtg	8	9	16	8	2	1	1	1	0	0	1	1	2	1	2	1	4	2	2	1	4	1	2			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr22:24379500A>G	uc002zze.3	-	3	265	c.212T>C	c.(211-213)CTG>CCG	p.L71P	GSTT1_uc002zzf.3_Intron|GSTT1_uc010gug.2_Intron|GSTT1_uc011ajl.1_5'UTR|GSTT1_uc010guh.2_Intron	NM_000853	NP_000844	P30711	GSTT1_HUMAN	glutathione S-transferase theta 1	71	GST N-terminal.				glutathione metabolic process	cytosol|soluble fraction	glutathione peroxidase activity|glutathione transferase activity			ovary(1)	1					Glutathione(DB00143)	CAGGTAGAGCAGGATGGCCAC	0.512									Myelodysplasia_and_Acute_Myeloid_Leukemia_(AML)_Familial				16	72					0	0	0	0	G	24379500	G	G	24379500	3	3	199	1	0	0	0	0	1	0	0	0	6884	188	7	5	522	5	GSTT1	22	24379500	Missense_Mutation	SNP	A	TCGA-CV-6940-01A-11D-1912-08	5808721	24379500	26925066	148	36605											
APOL1	8542	broad.mit.edu	37	chr22	36657700	36657700	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggaaaaagtgagcacacaGaatctgctactcctgctgac	15	7	9	10	0	1	3	0	2	1	1	2	4	2	4	1	1	4	3	1	1	5	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr22:36657700G>A	uc003apf.2	+	5	414	c.246G>A	c.(244-246)CAG>CAA	p.Q82Q	APOL1_uc011amn.1_5'UTR|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Silent_p.Q98Q|APOL1_uc011amo.1_5'UTR|APOL1_uc011amp.1_Silent_p.Q82Q|APOL1_uc011amq.1_Silent_p.Q64Q|APOL1_uc010gwx.2_5'UTR	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	82					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						TGAGCACACAGAATCTGCTAC	0.473													18	58					0	0	0	0	A	36657700	A	A	36657700	2	1	199	1	0	0	0	0	0	0	0	1	805	933	33	2		2	APOL1	22	36657700	Silent	SNP	G	TCGA-CV-6940-01A-11D-1912-08	12278200	36657700	14646866	149	36606											
NAGA	4668	broad.mit.edu	37	chr22	42463795	42463795	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccaggaaaggaatgccatGagggaagcgcttgggatccg	12	5	16	8	2	0	1	0	1	0	0	1	5	1	5	3	4	3	1	3	4	3	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr22:42463795G>C	uc003bbx.2	-	4	435	c.298C>G	c.(298-300)CAT>GAT	p.H100D	NAGA_uc003bby.2_Missense_Mutation_p.H100D|NAGA_uc003bbw.3_Missense_Mutation_p.H100D	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	100					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						GGAATGCCATGAGGGAAGCGC	0.607													17	99					0	0	0	0	C	42463795	C	C	42463795	3	2	199	1	0	0	0	0	1	0	0	0	10194	1290	45	2	965	2	NAGA	22	42463795	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	5806095	42463795	8840771	150	36607											
FAM19A5	25817	broad.mit.edu	37	chr22	49042418	49042418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctctctgcaggtcagctggCcgccggcacctgtgagattg	5	9	13	14	2	2	1	1	1	1	1	3	2	2	1	4	3	2	3	4	3	0	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chr22:49042418C>T	uc003bim.3	+	2	239	c.122C>T	c.(121-123)GCC>GTC	p.A41V	FAM19A5_uc003bio.3_Missense_Mutation_p.A34V	NM_001082967	NP_001076436	Q7Z5A7	F19A5_HUMAN	family with sequence similarity 19 (chemokine	41						extracellular region|integral to membrane				large_intestine(1)	1		all_cancers(38;2.95e-11)|all_epithelial(38;3.07e-10)|all_lung(38;2.89e-05)|Breast(42;0.000396)|Lung NSC(38;0.000471)|Ovarian(80;0.00934)|Lung SC(80;0.195)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0227)|BRCA - Breast invasive adenocarcinoma(115;0.119)		GGTCAGCTGGCCGCCGGCACC	0.587													21	47					0	0	0	0	T	49042418	T	T	49042418	3	4	199	1	0	0	0	0	1	0	0	0	5563	739	26	4	223	4	FAM19A5	22	49042418	Missense_Mutation	SNP	C	TCGA-CV-6940-01A-11D-1912-08	6578623	49042418	2262148	151	36608											
IL1RAPL2	26280	broad.mit.edu	37	chrX	105011444	105011444	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaatgcaaatcaggcactgTtgcagaggttataaacatga	15	10	9	7	0	2	2	2	1	0	1	2	2	2	2	0	2	3	5	0	2	5	3			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chrX:105011444T>C	uc004elz.1	+	11	2607	c.1851T>C	c.(1849-1851)TGT>TGC	p.C617C		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	617	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						TCAGGCACTGTTGCAGAGGTT	0.483													14	121					0	0	0	0	C	105011444	C	C	105011444	2	2	199	1	0	0	0	0	0	0	0	1	7701	1731	60	5		5	IL1RAPL2	23	105011444	Silent	SNP	T	TCGA-CV-6940-01A-11D-1912-08		105011444	50259116	152	36609											
PLXNA3	55558	broad.mit.edu	37	chrX	153694349	153694349	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgacaacctgggcctcttGtcccgagaggtgggcctgcg	5	8	16	12	2	1	2	0	1	1	1	2	3	2	2	4	4	2	0	4	4	1	1			TCGA-CV-6940-01A-11D-1912-08	TCGA-CV-6940-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	39f2e005-79f9-4c63-a6d6-0b378481a3ba	f92c1496-9e4b-4bc6-97df-635b907b5029	g.chrX:153694349G>T	uc004flm.2	+	14	2777	c.2604G>T	c.(2602-2604)TTG>TTT	p.L868F		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	868	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGGGCCTCTTGTCCCGAGAGG	0.652													39	15					2.24893e-16	3.21666e-16	1	0	T	153694349	T	T	153694349	3	4	199	1	0	0	0	0	1	0	0	0	12176	1368	48	4	2654	4	PLXNA3	23	153694349	Missense_Mutation	SNP	G	TCGA-CV-6940-01A-11D-1912-08	48682905	153694349	1576211	153	36610											
KLHL17	339451	broad.mit.edu	37	chr1	899313	899313	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccacagtgctgaacgctacGaccccctgaccggaacgtgg	9	5	11	16	4	0	2	0	2	0	0	0	4	0	3	4	2	4	2	4	2	3	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:899313G>A	uc001aca.1	+	9	1476	c.1369G>A	c.(1369-1371)GAC>AAC	p.D457N	KLHL17_uc001acc.1_RNA|PLEKHN1_uc001acd.2_5'Flank|PLEKHN1_uc001acf.2_5'Flank|PLEKHN1_uc001ace.2_5'Flank	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	457	Interaction with F-actin (By similarity).|Kelch 3.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TGAACGCTACGACCCCCTGAC	0.687													32	113					0	0	0	0	A	899313	A	A	899313	3	1	200	1	0	0	0	0	1	0	0	0	8411	1058	37	1	1403	1	KLHL17	1	899313	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08		899313	248351308	1	36611											
CDK11B	984	broad.mit.edu	37	chr1	1573159	1573159	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgggatgctgggccttgaGgatggtgttgatctccctca	5	13	15	8	0	2	2	1	2	1	0	3	4	2	4	2	4	1	3	2	4	0	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:1573159G>A	uc001agv.1	-	17	1540	c.1429C>T	c.(1429-1431)CTC>TTC	p.L477F	CDK11B_uc009vkj.2_Missense_Mutation_p.L134F|CDK11B_uc001ags.1_Missense_Mutation_p.L335F|CDK11B_uc001agt.1_Missense_Mutation_p.L260F|CDK11B_uc001aha.1_Missense_Mutation_p.L443F|CDK11B_uc001agw.1_Missense_Mutation_p.L432F|CDK11B_uc001agy.1_Missense_Mutation_p.L475F|CDK11B_uc001agx.1_Missense_Mutation_p.L466F|CDK11B_uc001agz.1_Missense_Mutation_p.L221F	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	490	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						TGGGCCTTGAGGATGGTGTTG	0.567													39	195					0	0	0	0	A	1573159	A	A	1573159	3	1	200	1	0	0	0	0	1	0	0	0	3142	1000	35	4	951	4	CDK11B	1	1573159	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	673846	1573159	247677462	2	36612											
RPL22	6146	broad.mit.edu	37	chr1	6253065	6253065	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtcaccacccctccaccaAggttcccagcttttccgttc	6	11	6	18	1	1	0	1	0	0	0	5	0	4	0	7	2	1	3	7	2	1	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:6253065A>G	uc001amd.2	-	3	213	c.167T>C	c.(166-168)CTT>CCT	p.L56P	RPL22_uc001ame.2_Missense_Mutation_p.L56P	NM_000983	NP_000974	P35268	RL22_HUMAN	ribosomal protein L22 proprotein	56					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|RNA binding|structural constituent of ribosome				0	Ovarian(185;0.0634)	all_cancers(23;2.78e-38)|all_epithelial(116;8.88e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.53e-38)|GBM - Glioblastoma multiforme(13;3.33e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.8e-19)|Colorectal(212;6.8e-08)|COAD - Colon adenocarcinoma(227;8.04e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CCCTCCACCAAGGTTCCCAGC	0.468			T	RUNX1	AML|CML								9	61					0	0	0	0	G	6253065	G	G	6253065	3	3	200	1	0	0	0	0	1	0	0	0	13633	72	3	5	227	5	RPL22	1	6253065	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08	4679906	6253065	242997556	3	36613											
KDM1A	23028	broad.mit.edu	37	chr1	23385657	23385657	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttatgaagccaacggacaAgctgtaagtcgaggacaaac	15	7	10	9	2	0	1	0	1	0	0	1	4	0	3	1	2	4	2	1	2	6	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:23385657A>G	uc001bgi.2	+	8	1253	c.1104A>G	c.(1102-1104)CAA>CAG	p.Q368Q	KDM1A_uc001bgj.2_Silent_p.Q388Q	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	368	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						CCAACGGACAAGCTGTAAGTC	0.368													3	14					0	0	0	0	G	23385657	G	G	23385657	2	3	200	1	0	0	0	0	0	0	0	1	8161	69	3	5		5	KDM1A	1	23385657	Silent	SNP	A	TCGA-CV-6941-01A-11D-1912-08	17132592	23385657	225864964	4	36614											
CLIC4	25932	broad.mit.edu	37	chr1	25153564	25153564	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaatggacatctttgccaaAttctctgcatatatcaagaa	14	12	7	8	0	3	1	1	0	2	1	4	3	3	3	1	2	2	1	1	2	6	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:25153564A>C	uc001bjo.2	+	4	657	c.372A>C	c.(370-372)AAA>AAC	p.K124N	CLIC4_uc001bjn.2_RNA|CLIC4_uc001bjp.1_Missense_Mutation_p.K104N	NM_013943	NP_039234	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	124	GST C-terminal.				cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)		TCTTTGCCAAATTCTCTGCAT	0.348													30	120					0	0	0	0	C	25153564	C	C	25153564	3	2	200	1	0	0	0	0	1	0	0	0	3543	98	4	5	386	5	CLIC4	1	25153564	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08	1767907	25153564	224097057	5	36615											
ELAVL4	1996	broad.mit.edu	37	chr1	50666796	50666796	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcctcaacgggtaccgcctGggagacagagtgttgcaagt	10	7	14	10	2	1	2	1	0	0	2	1	3	1	2	3	2	4	3	3	2	3	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:50666796G>T	uc001csb.2	+	7	1357	c.1089G>T	c.(1087-1089)CTG>CTT	p.L363L	ELAVL4_uc001cry.3_Silent_p.L352L|ELAVL4_uc001crz.3_Silent_p.L349L|ELAVL4_uc001csa.3_Silent_p.L366L|ELAVL4_uc001csc.3_Silent_p.L349L|ELAVL4_uc010omz.1_Silent_p.L354L	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	363	RRM 3.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						GGTACCGCCTGGGAGACAGAG	0.448													15	30					1.15088e-07	3.37389e-07	1	0	T	50666796	T	T	50666796	2	4	200	1	0	0	0	0	0	0	0	1	5076	1335	47	4		4	ELAVL4	1	50666796	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	25513232	50666796	198583825	6	36616											
DEPDC1	55635	broad.mit.edu	37	chr1	68947901	68947901	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggtttcatgataatttcAgccactggtgtattgatata	10	18	8	5	0	2	2	2	2	0	0	2	2	2	2	1	2	1	2	1	2	4	8			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:68947901A>C	uc001dem.3	-	8	1707	c.1590T>G	c.(1588-1590)GCT>GCG	p.A530A	DEPDC1_uc001dej.3_5'UTR|DEPDC1_uc001dek.3_Intron|DEPDC1_uc001del.3_Intron	NM_001114120	NP_001107592	Q5TB30	DEP1A_HUMAN	DEP domain containing 1 isoform a	530					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		TGATAATTTCAGCCACTGGTG	0.388													44	152					0	0	0	0	C	68947901	C	C	68947901	2	2	200	1	0	0	0	0	0	0	0	1	4461	175	7	5		5	DEPDC1	1	68947901	Silent	SNP	A	TCGA-CV-6941-01A-11D-1912-08	18281105	68947901	180302720	7	36617											
SLC44A5	204962	broad.mit.edu	37	chr1	75688097	75688097	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggattcgattcctgaggAagatcagcatgaggatgaca	12	9	12	8	2	1	4	1	3	0	1	4	8	2	7	1	3	1	1	1	3	1	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:75688097A>C	uc001dgu.2	-	14	1178	c.1034T>G	c.(1033-1035)TTC>TGC	p.F345C	SLC44A5_uc001dgt.2_Missense_Mutation_p.F345C|SLC44A5_uc001dgs.2_Missense_Mutation_p.F303C|SLC44A5_uc001dgr.2_Missense_Mutation_p.F303C|SLC44A5_uc010oqz.1_Missense_Mutation_p.F384C|SLC44A5_uc010ora.1_Missense_Mutation_p.F339C|SLC44A5_uc010orb.1_Missense_Mutation_p.F215C	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	345	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						ATTCCTGAGGAAGATCAGCAT	0.388													30	30					0	0	0	0	C	75688097	C	C	75688097	3	2	200	1	0	0	0	0	1	0	0	0	14703	246	9	5	1280	5	SLC44A5	1	75688097	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08	6740196	75688097	173562524	8	36618											
COL11A1	1301	broad.mit.edu	37	chr1	103345449	103345449	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaccatattgatggaattTccttcaacatctaagtatga	13	14	6	8	0	2	2	1	2	1	0	3	3	3	3	2	1	2	2	2	1	5	6			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:103345449T>C	uc001dul.2	-	66	5382	c.5064A>G	c.(5062-5064)GGA>GGG	p.G1688G	COL11A1_uc001duk.2_Silent_p.G884G|COL11A1_uc001dum.2_Silent_p.G1700G|COL11A1_uc001dun.2_Silent_p.G1649G|COL11A1_uc009weh.2_Silent_p.G1572G	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1688	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGATGGAATTTCCTTCAACAT	0.388													10	17					0	0	0	0	C	103345449	C	C	103345449	2	2	200	1	0	0	0	0	0	0	0	1	3682	1770	62	5		5	COL11A1	1	103345449	Silent	SNP	T	TCGA-CV-6941-01A-11D-1912-08	27657352	103345449	145905172	9	36619											
SH2D1B	117157	broad.mit.edu	37	chr1	162368816	162368816	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcccctgatttggttttTcaaatttggagatcagttcc	8	16	7	10	0	2	2	2	1	0	1	4	3	4	2	4	2	0	2	4	2	1	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:162368816T>C	uc001gbz.1	-	3	382	c.260A>G	c.(259-261)GAA>GGA	p.E87G	SH2D1B_uc001gca.1_Intron	NM_053282	NP_444512	O14796	SH21B_HUMAN	SH2 domain containing 1B	87	SH2.									pancreas(1)	1	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			ATTTGGTTTTTCAAATTTGGA	0.398													6	64					0	0	0	0	C	162368816	C	C	162368816	3	2	200	1	0	0	0	0	1	0	0	0	14296	1783	62	5	146	5	SH2D1B	1	162368816	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	59023367	162368816	86881805	10	36620											
ILDR2	387597	broad.mit.edu	37	chr1	166927307	166927307	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggccaccttcttcttgtcGggcactgtgacctgaaggcc	6	11	11	13	1	2	2	0	2	2	0	3	2	2	2	4	3	0	1	4	3	1	3	rs143548938		TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:166927307G>A	uc001gdx.1	-	2	134	c.78C>T	c.(76-78)CCC>CCT	p.P26P		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	26	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1						TCTTCTTGTCGGGCACTGTGA	0.522													9	120					0	0	0	0	A	166927307	A	A	166927307	2	1	200	1	0	0	0	0	0	0	0	1	7749	1103	39	1		1	ILDR2	1	166927307	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	4558491	166927307	82323314	11	36621											
TNN	63923	broad.mit.edu	37	chr1	175067683	175067683	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatggtgcacgtgtgggccCagaagggggaccaggagagc	10	4	18	9	1	0	2	0	0	0	2	0	4	0	3	2	5	2	1	2	5	1	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:175067683C>A	uc001gkl.1	+	9	2184	c.2071C>A	c.(2071-2073)CAG>AAG	p.Q691K	TNN_uc010pmx.1_Missense_Mutation_p.Q602K	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	691	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CGTGTGGGCCCAGAAGGGGGA	0.602													35	33					7.11191e-15	2.16466e-14	1	0	A	175067683	A	A	175067683	3	1	200	1	0	0	0	0	1	0	0	0	16389	595	21	4	2101	4	TNN	1	175067683	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	8140376	175067683	74182938	12	36622											
QSOX1	5768	broad.mit.edu	37	chr1	180135628	180135628	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttttttgtcctttcagccTggaggccggccctgtatctc	3	15	11	12	1	2	0	1	0	1	0	4	1	3	1	4	4	1	2	4	4	1	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:180135628T>C	uc001gnz.2	+	2	343	c.268T>C	c.(268-270)TGG>CGG	p.W90R	QSOX1_uc001gny.2_Missense_Mutation_p.W90R|QSOX1_uc001goa.2_Missense_Mutation_p.W90R	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	90	Thioredoxin.				cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						CCTTTCAGCCTGGAGGCCGGC	0.592													3	70					0	0	0	0	C	180135628	C	C	180135628	3	2	200	1	0	0	0	0	1	0	0	0	12948	1580	55	5	274	5	QSOX1	1	180135628	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	5067945	180135628	69114993	13	36623											
RGS1	5996	broad.mit.edu	37	chr1	192548327	192548327	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattaaagcaccaacccccAcgtgttttgatgaagcacaa	15	8	7	11	1	0	3	0	2	0	1	0	3	0	3	3	0	3	3	3	0	5	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:192548327A>C	uc001gsi.1	+	5	571	c.505A>C	c.(505-507)ACG>CCG	p.T169P		NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	169	RGS.				immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				ACCAACCCCCACGTGTTTTGA	0.338													42	23					0	0	0	0	C	192548327	C	C	192548327	3	2	200	1	0	0	0	0	1	0	0	0	13357	159	6	5	523	5	RGS1	1	192548327	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08	12412699	192548327	56702294	14	36624											
TIMM17A	10440	broad.mit.edu	37	chr1	201938617	201938617	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcctcagtttgcagaagacCcctcccagttgccttcaact	8	11	7	15	0	2	2	2	0	0	2	4	2	4	2	5	0	3	3	5	0	2	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:201938617C>T	uc001gxc.2	+	6	487	c.451C>T	c.(451-453)CCC>TCC	p.P151S		NM_006335	NP_006326	Q99595	TI17A_HUMAN	translocase of inner mitochondrial membrane 17	151					protein targeting to mitochondrion	integral to membrane|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity				0						TGCAGAAGACCCCTCCCAGTT	0.363													51	42					0	0	0	0	T	201938617	T	T	201938617	3	4	200	1	0	0	0	0	1	0	0	0	15974	623	22	4	473	4	TIMM17A	1	201938617	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	9390290	201938617	47312004	15	36625											
PROX1	5629	broad.mit.edu	37	chr1	214184888	214184888	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagatgcattacctctcagCtcatcaagtggtttagcaat	12	12	7	10	0	3	1	3	0	1	1	4	1	3	1	1	1	4	4	1	1	4	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:214184888C>G	uc001hkh.2	+	4	2130	c.1858C>G	c.(1858-1860)CTC>GTC	p.L620V		NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	620	Prospero-type homeobox.				aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TACCTCTCAGCTCATCAAGTG	0.373													3	74					0	0	0	0	G	214184888	G	G	214184888	3	3	200	1	0	0	0	0	1	0	0	0	12622	797	28	4	1868	4	PROX1	1	214184888	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	12246271	214184888	35065733	16	36626											
OR2AK2	391191	broad.mit.edu	37	chr1	248129000	248129000	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtatgtgttcttggcccttGgtggaactgaagcccttctc	5	14	11	11	1	2	1	0	1	2	0	3	2	2	2	2	3	2	2	2	3	3	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:248129000G>T	uc010pzd.1	+	1	367	c.367G>T	c.(367-369)GGT>TGT	p.G123C	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	123	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CTTGGCCCTTGGTGGAACTGA	0.448													15	218					1.02788e-11	3.07812e-11	1	0	T	248129000	T	T	248129000	3	4	200	1	0	0	0	0	1	0	0	0	11040	1348	47	4	369	4	OR2AK2	1	248129000	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	33944112	248129000	1121621	17	36627											
OR2G6	391211	broad.mit.edu	37	chr1	248685814	248685814	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacttttaaaccccattatCtacactctgagaaacaaaga	16	10	3	12	0	2	2	0	1	2	2	2	3	2	2	3	0	3	0	3	0	6	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr1:248685814C>A	uc001ien.1	+	1	867	c.867C>A	c.(865-867)ATC>ATA	p.I289I		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCCCATTATCTACACTCTGA	0.443													9	60					3.86212e-05	0.000108101	1	0	A	248685814	A	A	248685814	2	1	200	1	0	0	0	0	0	0	0	1	11054	903	32	2		2	OR2G6	1	248685814	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	556814	248685814	564807	18	36628											
MYCN	4613	broad.mit.edu	37	chr2	16085953	16085953	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcccccgaaactctgacTcggaggacagtgagcgtcgc	9	6	13	13	4	1	3	0	3	1	0	3	6	1	5	2	2	3	0	2	2	1	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr2:16085953T>A	uc002rci.2	+	3	1429	c.1129T>A	c.(1129-1131)TCG>ACG	p.S377T	MYCN_uc010yjr.1_Missense_Mutation_p.S369T	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	377					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			AAACTCTGACTCGGAGGACAG	0.607			A		neuroblastoma								34	31					0	0	0	0	A	16085953	A	A	16085953	3	1	200	1	0	0	0	0	1	0	0	0	10074	1551	54	5	1135	5	MYCN	2	16085953	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08		16085953	227113420	19	36629											
NT5C1B	93034	broad.mit.edu	37	chr2	18766048	18766048	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttgggcccaggcctccggaTtctcttgcattttggtgctg	3	14	12	12	1	1	0	0	0	1	0	3	1	2	1	3	4	2	2	3	4	0	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr2:18766048T>C	uc002rcz.2	-	5	739	c.635A>G	c.(634-636)AAT>AGT	p.N212S	NT5C1B_uc002rcy.2_Missense_Mutation_p.N212S|NT5C1B_uc010exr.2_Missense_Mutation_p.N154S|NT5C1B_uc010yju.1_Missense_Mutation_p.N152S|NT5C1B_uc002rda.2_Missense_Mutation_p.N152S|NT5C1B_uc010yjv.1_Missense_Mutation_p.N229S|NT5C1B_uc010yjw.1_Missense_Mutation_p.N195S|NT5C1B_uc010exs.2_Missense_Mutation_p.N214S|NT5C1B_uc002rdb.1_Missense_Mutation_p.N4S	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	212					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GGCCTCCGGATTCTCTTGCAT	0.701													13	30					0	0	0	0	C	18766048	C	C	18766048	3	2	200	1	0	0	0	0	1	0	0	0	10740	1493	52	5	1221	5	NT5C1B	2	18766048	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	2680095	18766048	224433325	20	36630											
C2orf61	285051	broad.mit.edu	37	chr2	47382368	47382368	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccttattgaggtggaagcgGtggcgacggctggctggtcc	5	9	17	10	3	0	1	0	1	0	0	1	3	1	2	2	7	1	2	2	7	2	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr2:47382368G>A	uc002rvs.2	-	1	150	c.23C>T	c.(22-24)ACC>ATC	p.T8I	C2orf61_uc010fbd.2_Intron|C2orf61_uc010yog.1_Missense_Mutation_p.T8I	NM_173649	NP_775920	Q8N801	CB061_HUMAN	hypothetical protein LOC285051 isoform 2	8								p.0?(2)			0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GGTGGAAGCGGTGGCGACGGC	0.642													21	28					0	0	0	0	A	47382368	A	A	47382368	3	1	200	1	0	0	0	0	1	0	0	0	2190	1261	44	4	766	4	C2orf61	2	47382368	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	28616320	47382368	195817005	21	36631											
OTX1	5013	broad.mit.edu	37	chr2	63283436	63283436	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aaggaccaagcctcatggcgGttccaggtcttgtgagccca	9	8	12	12	1	2	1	1	1	1	0	3	2	3	2	4	4	2	1	4	4	2	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr2:63283436G>T	uc002scd.2	+	5	1298	c.1050G>T	c.(1048-1050)CGG>CGT	p.R350R	OTX1_uc010ypt.1_Silent_p.R284R	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	350						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					CCTCATGGCGGTTCCAGGTCT	0.592													6	34					2.0095e-06	5.76954e-06	1	0	T	63283436	T	T	63283436	2	4	200	1	0	0	0	0	0	0	0	1	11374	1248	44	4		4	OTX1	2	63283436	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	15901068	63283436	179915937	22	36632											
ANKRD57	65124	broad.mit.edu	37	chr2	110373348	110373349	+	Frame_Shift_Del	DEL	CT	-	-																															cgcatctcatcacctacaaaCtctcacacgccctagaagat																										TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr2:110373348_110373349delCT	uc002tfb.2	+	1	1438_1439	c.1282_1283delCT	c.(1282-1284)CTCfs	p.L428fs	SEPT10_uc010ywu.1_5'Flank|SEPT10_uc002tew.2_5'Flank|SEPT10_uc002tex.2_5'Flank|SEPT10_uc002tey.2_5'Flank|SEPT10_uc010ywv.1_5'Flank	NM_023016	NP_075392	Q53LP3	ANR57_HUMAN	ankyrin repeat domain 57	428											0						CACCTACAAACTCTCACACGCC	0.644													---	---	---								-	110373349	-	-	110373348	7	5	200	1	0	1	0	1	0	0	0	0	683	565	20	0	1284	0	ANKRD57	2	110373348	Frame_Shift_Del	DEL	CT	TCGA-CV-6941-01A-11D-1912-08	47089912	110373348	132826025	23	36633											
SAP130	79595	broad.mit.edu	37	chr2	128712714	128712714	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgggtggagtgatggggacCgctccaggaatggttgaaag	10	8	18	5	1	0	2	0	2	0	0	1	5	1	5	2	6	0	2	2	6	2	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr2:128712714C>T	uc002tpp.2	-	15	2373	c.2241G>A	c.(2239-2241)GCG>GCA	p.A747A	SAP130_uc002tpn.2_Silent_p.A507A|SAP130_uc002tpo.2_Silent_p.A527A|SAP130_uc010fmd.2_Silent_p.A782A|SAP130_uc002tpq.1_Silent_p.A755A	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	747	Pro-rich.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TGATGGGGACCGCTCCAGGAA	0.607													13	75					0	0	0	0	T	128712714	T	T	128712714	2	4	200	1	0	0	0	0	0	0	0	1	13896	639	23	1		1	SAP130	2	128712714	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	18339366	128712714	114486659	24	36634											
LRP1B	53353	broad.mit.edu	37	chr2	141294272	141294272	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aataagcgttgcaggaggaaTttttagctgcaagaaaaaaa	18	9	10	4	1	0	1	0	0	0	1	0	3	0	3	0	2	4	4	0	2	8	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr2:141294272T>A	uc002tvj.1	-	46	8492	c.7520A>T	c.(7519-7521)AAT>ATT	p.N2507I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2507	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCAGGAGGAATTTTTAGCTGC	0.318										TSP Lung(27;0.18)			11	19					0	0	0	0	A	141294272	A	A	141294272	3	1	200	1	0	0	0	0	1	0	0	0	9005	1493	52	5	6463	5	LRP1B	2	141294272	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	12581558	141294272	101905101	25	36635											
NOSTRIN	115677	broad.mit.edu	37	chr2	169690790	169690790	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgaagcacttttccagctTgtagaaagctccaagcaatc	13	10	7	11	0	0	2	0	1	0	1	3	2	2	2	2	0	4	5	2	0	5	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr2:169690790T>C	uc002ueg.2	+	7	463	c.459T>C	c.(457-459)CTT>CTC	p.L153L	NOSTRIN_uc002uef.2_Silent_p.L153L|NOSTRIN_uc002uei.2_Silent_p.L36L|NOSTRIN_uc010fpu.2_Silent_p.L125L|NOSTRIN_uc002ueh.2_Silent_p.L75L|NOSTRIN_uc002uej.2_Silent_p.L36L	NM_001039724	NP_001034813	Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficker isoform 2	153					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0						TTTTCCAGCTTGTAGAAAGCT	0.443													9	28					0	0	0	0	C	169690790	C	C	169690790	2	2	200	1	0	0	0	0	0	0	0	1	10600	1799	63	5		5	NOSTRIN	2	169690790	Silent	SNP	T	TCGA-CV-6941-01A-11D-1912-08	28396518	169690790	73508583	26	36636											
TTN	7273	broad.mit.edu	37	chr2	179612845	179612845	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttcaaatgtgagatggaaCttctgcctccattttctaga	10	16	7	8	0	3	2	1	1	2	2	4	4	4	3	2	1	2	0	2	1	3	6			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr2:179612845C>A	uc002unb.2	-	46	14506	c.14282G>T	c.(14281-14283)AGT>ATT	p.S4761I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGATGGAACTTCTGCCTCC	0.408													24	35					2.32416e-17	7.15224e-17	1	0	A	179612845	A	A	179612845	3	1	200	1	0	0	0	0	1	0	0	0	16803	565	20	4	96015	4	TTN	2	179612845	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	9922055	179612845	63586528	27	36637											
TNS1	7145	broad.mit.edu	37	chr2	218674659	218674659	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtggctttagagatggcCtgtggcccagtgagtgactc	7	11	15	8	0	0	3	0	2	0	1	1	5	0	3	2	3	0	1	2	3	1	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr2:218674659C>T	uc002vgt.2	-	30	5246	c.4848G>A	c.(4846-4848)CAG>CAA	p.Q1616Q	TNS1_uc002vgr.2_Silent_p.Q1602Q|TNS1_uc002vgs.2_Silent_p.Q1595Q|TNS1_uc002vgq.2_Silent_p.Q116Q	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1616						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TAGAGATGGCCTGTGGCCCAG	0.572													15	14					0	0	0	0	T	218674659	T	T	218674659	2	4	200	1	0	0	0	0	0	0	0	1	16409	680	24	4		4	TNS1	2	218674659	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	39061814	218674659	24524714	28	36638											
GRIP2	80852	broad.mit.edu	37	chr3	14552798	14552798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caatggccagtagcttgtcgCctggctccagggtgcccgtc	5	9	13	14	2	0	0	0	0	0	0	3	0	1	0	4	3	2	3	4	3	2	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr3:14552798C>T	uc011avi.1	-	17	2102	c.2102G>A	c.(2101-2103)GGC>GAC	p.G701D	GRIP2_uc010heh.2_RNA|GRIP2_uc011avh.1_Missense_Mutation_p.G232D	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	603	PDZ 5.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						TAGCTTGTCGCCTGGCTCCAG	0.617													21	21					0	0	0	0	T	14552798	T	T	14552798	3	4	200	1	0	0	0	0	1	0	0	0	6827	739	26	4	1358	4	GRIP2	3	14552798	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08		14552798	183469632	29	36639											
KLHDC8B	200942	broad.mit.edu	37	chr3	49213226	49213226	+	Frame_Shift_Del	DEL	G	-	-																															aggcactgtgtctgcgtgatGgggtctgaaggcttggtggg																										TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr3:49213226delG	uc003cwh.2	+	6	1242	c.1057delG	c.(1057-1059)GGGfs	p.G353fs	KLHDC8B_uc003cwi.1_3'UTR	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	353	Kelch 8.					cytoplasm					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCTGCGTGATGGGGTCTGAAG	0.602													---	---	---								-	49213226	-	-	49213226	7	5	200	1	0	1	0	1	0	0	0	0	8402	1348	47	0	1075	0	KLHDC8B	3	49213226	Frame_Shift_Del	DEL	G	TCGA-CV-6941-01A-11D-1912-08	34660428	49213226	148809204	30	36640											
USP4	7375	broad.mit.edu	37	chr3	49329942	49329942	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagagcatggtgcatactcaCcttcacagctgttcctggag	9	10	10	12	0	2	1	2	0	0	1	3	2	3	2	2	2	4	4	2	2	1	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr3:49329942C>G	uc003cwq.2	-	15	2051	c.1972_splice	c.e15+1	p.G658_splice	USP4_uc003cwo.2_Splice_Site_p.G370_splice|USP4_uc003cwp.2_Splice_Site_p.G388_splice|USP4_uc003cwr.2_Splice_Site_p.G611_splice	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a						negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		TGCATACTCACCTTCACAGCT	0.512													5	3					0	0	0	0	G	49329942	G	G	49329942	5	3	200	1	0	0	0	0	0	0	1	0	17139	521	18	4	950	4	USP4	3	49329942	Splice_Site	SNP	C	TCGA-CV-6941-01A-11D-1912-08	116716	49329942	148692488	31	36641											
CACNA1D	776	broad.mit.edu	37	chr3	53804530	53804530	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attggtgaagcttctcagcaGgggggaaggcatccggacat	10	8	15	8	1	1	1	1	1	1	0	3	3	2	3	1	6	2	3	1	6	2	2	rs148194645		TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr3:53804530G>A	uc003dgv.3	+	32	4158	c.3995G>A	c.(3994-3996)AGG>AAG	p.R1332K	CACNA1D_uc003dgu.3_Missense_Mutation_p.R1352K|CACNA1D_uc003dgy.3_Missense_Mutation_p.R1317K|CACNA1D_uc003dgw.3_Missense_Mutation_p.R999K|CACNA1D_uc003dgx.1_Missense_Mutation_p.R508K	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1332	IV.|Helical; Name=S4 of repeat IV; (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CTTCTCAGCAGGGGGGAAGGC	0.448													25	22					0	0	0	0	A	53804530	A	A	53804530	3	1	200	1	0	0	0	0	1	0	0	0	2553	1000	35	4	4293	4	CACNA1D	3	53804530	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	4474588	53804530	144217900	32	36642											
C3orf63	23272	broad.mit.edu	37	chr3	56657144	56657144	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagatttatctctatccaagCtttcagtataagcagataag	14	13	7	7	0	2	2	1	0	1	2	4	3	3	2	1	0	2	3	1	0	6	7			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr3:56657144C>G	uc003did.3	-	23	4852	c.4751G>C	c.(4750-4752)AGC>ACC	p.S1584T	C3orf63_uc003dib.3_Missense_Mutation_p.S703T|C3orf63_uc003dic.3_Missense_Mutation_p.S1208T|C3orf63_uc003die.3_3'UTR	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1645										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		TCTATCCAAGCTTTCAGTATA	0.363													27	28					0	0	0	0	G	56657144	G	G	56657144	3	3	200	1	0	0	0	0	1	0	0	0	2249	797	28	4	82	4	C3orf63	3	56657144	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	2852614	56657144	141365286	33	36643											
ZNF654	55279	broad.mit.edu	37	chr3	88189761	88189761	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatatagtcaatggacacaGtgaaatagagcaaacacctt	17	9	8	7	0	1	3	1	2	0	1	1	4	1	4	1	1	2	1	1	1	6	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr3:88189761G>C	uc003dqv.2	+	1	1500	c.1301G>C	c.(1300-1302)AGT>ACT	p.S434T	CGGBP1_uc003dqu.2_Intron	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		AATGGACACAGTGAAATAGAG	0.353													36	31					0	0	0	0	C	88189761	C	C	88189761	3	2	200	1	0	0	0	0	1	0	0	0	18134	1029	36	4	1303	4	ZNF654	3	88189761	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	31532617	88189761	109832669	34	36644											
OR5H15	403274	broad.mit.edu	37	chr3	97888271	97888271	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agccttttccacctgtggagCccatctcttctctgtctgtt	4	16	7	14	0	3	0	0	0	3	0	6	1	4	1	4	1	2	1	4	1	0	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr3:97888271C>A	uc011bgu.1	+	1	728	c.728C>A	c.(727-729)GCC>GAC	p.A243D		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ACCTGTGGAGCCCATCTCTTC	0.428													21	65					1.1804e-14	3.57327e-14	1	0	A	97888271	A	A	97888271	3	1	200	1	0	0	0	0	1	0	0	0	11215	739	26	4	730	4	OR5H15	3	97888271	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	9698510	97888271	100134159	35	36645											
TMEM108	66000	broad.mit.edu	37	chr3	133099858	133099858	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atttcctcaaccgcctggtcCccgccgggacctggaagcct	6	8	10	17	3	1	0	1	0	0	0	3	2	3	2	8	3	2	0	8	3	2	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr3:133099858C>T	uc003eph.2	+	4	1577	c.1303C>T	c.(1303-1305)CCC>TCC	p.P435S	TMEM108_uc003epi.2_Missense_Mutation_p.P435S|TMEM108_uc003epj.1_Missense_Mutation_p.P435S|TMEM108_uc003epk.2_Intron|TMEM108_uc003epm.2_Missense_Mutation_p.P386S	NM_023943	NP_076432	Q6UXF1	TM108_HUMAN	transmembrane protein 108 precursor	435	Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)	4						CCGCCTGGTCCCCGCCGGGAC	0.632													22	36					0	0	0	0	T	133099858	T	T	133099858	3	4	200	1	0	0	0	0	1	0	0	0	16090	623	22	4	1309	4	TMEM108	3	133099858	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	35211587	133099858	64922572	36	36646											
KLHL24	54800	broad.mit.edu	37	chr3	183368452	183368452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taatgaccacagggaaagccGagaaatgttggttgagatca	15	8	12	6	1	1	3	1	2	0	2	1	6	1	4	2	2	1	2	2	2	3	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr3:183368452G>A	uc003flv.2	+	3	603	c.308G>A	c.(307-309)CGA>CAA	p.R103Q	KLHL24_uc003flw.2_Missense_Mutation_p.R103Q|KLHL24_uc003flx.2_Missense_Mutation_p.R103Q	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	103	BTB.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			AGGGAAAGCCGAGAAATGTTG	0.398													42	103					0	0	0	0	A	183368452	A	A	183368452	3	1	200	1	0	0	0	0	1	0	0	0	8418	1058	37	1	310	1	KLHL24	3	183368452	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	50268594	183368452	14653978	37	36647											
YEATS2	55689	broad.mit.edu	37	chr3	183521945	183521945	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatgacggggactccatcgaGgacgtgctgacccagatcga	11	6	13	11	4	0	3	0	2	0	1	3	7	1	5	2	3	1	1	2	3	1	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr3:183521945G>C	uc003fly.2	+	27	3948	c.3753G>C	c.(3751-3753)GAG>GAC	p.E1251D	uc003fma.1_3'UTR	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1251					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ACTCCATCGAGGACGTGCTGA	0.612													10	85					0	0	0	0	C	183521945	C	C	183521945	3	2	200	1	0	0	0	0	1	0	0	0	17540	991	35	4	3855	4	YEATS2	3	183521945	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	153493	183521945	14500485	38	36648											
TMEM175	84286	broad.mit.edu	37	chr4	949582	949582	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcacccagtggaagtcttctCgtttgacctccacgagccac	8	10	8	15	2	3	1	1	1	2	0	5	3	4	2	4	1	1	1	4	1	1	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr4:949582C>T	uc003gbq.2	+	10	844	c.746C>T	c.(745-747)TCG>TTG	p.S249L	TMEM175_uc010ibl.1_Missense_Mutation_p.S249L|TMEM175_uc003gbp.1_Missense_Mutation_p.S167L|TMEM175_uc003gbr.2_Missense_Mutation_p.S167L|TMEM175_uc003gbu.2_Missense_Mutation_p.S167L|TMEM175_uc003gbs.2_Missense_Mutation_p.S132L|TMEM175_uc003gbt.2_Missense_Mutation_p.S132L|TMEM175_uc003gbv.2_Missense_Mutation_p.S132L|TMEM175_uc010ibm.2_Missense_Mutation_p.S65L	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	249						integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GAAGTCTTCTCGTTTGACCTC	0.637													7	20					0	0	0	0	T	949582	T	T	949582	3	4	200	1	0	0	0	0	1	0	0	0	16157	893	31	1	780	1	TMEM175	4	949582	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08		949582	190204694	39	36649											
FGFR3	2261	broad.mit.edu	37	chr4	1801019	1801019	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccggccagcaggagcagttgGtcttcggcagcggggatgct	6	7	17	11	3	1	0	0	0	1	0	2	2	1	2	2	6	4	5	2	6	0	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr4:1801019G>A	uc003gdr.3	+	3	404	c.148G>A	c.(148-150)GTC>ATC	p.V50I	FGFR3_uc003gdu.2_Missense_Mutation_p.V50I|FGFR3_uc003gds.3_Missense_Mutation_p.V50I|FGFR3_uc003gdq.3_Missense_Mutation_p.V50I|FGFR3_uc010icb.1_5'Flank|FGFR3_uc003gdt.1_5'Flank	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	50	Ig-like C2-type 1.|Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GGAGCAGTTGGTCTTCGGCAG	0.677		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				14	61					0	0	0	0	A	1801019	A	A	1801019	3	1	200	1	0	0	0	0	1	0	0	0	5899	1261	44	4	154	4	FGFR3	4	1801019	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	851437	1801019	189353257	40	36650											
COPS4	51138	broad.mit.edu	37	chr4	83970432	83970433	+	Frame_Shift_Ins	INS	-	A	A																															aatctatcacttcaccttggINSaaaagatccagcctagagtc																										TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr4:83970432_83970433insA	uc003hoa.2	+	3	407_408	c.268_269insA	c.(268-270)GAAfs	p.E90fs	COPS4_uc003hob.2_Frame_Shift_Ins_p.E90fs|COPS4_uc010ijw.2_Frame_Shift_Ins_p.E90fs|COPS4_uc010ijx.2_Frame_Shift_Ins_p.E90fs	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	90					cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				CTTCACCTTGGAAAAGATCCAG	0.406													---	---	---								A	83970433	A	A	83970432	7	5	200	1	0	1	1	0	0	0	0	0	3750	1175	41	0	278	0	COPS4	4	83970432	Frame_Shift_Ins	INS	-	TCGA-CV-6941-01A-11D-1912-08	82169413	83970432	107183844	41	36651											
GRID2	2895	broad.mit.edu	37	chr4	94031921	94031921	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccgtggaatacaggagttCttggacaaagtctctcagca	12	10	10	9	1	3	0	1	0	2	0	5	3	4	3	1	3	2	2	1	3	3	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr4:94031921C>T	uc011cdt.1	+	4	810	c.552C>T	c.(550-552)TTC>TTT	p.F184F	GRID2_uc010ikx.2_Silent_p.F184F|GRID2_uc011cdu.1_Silent_p.F89F|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	184	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TACAGGAGTTCTTGGACAAAG	0.383													20	71					0	0	0	0	T	94031921	T	T	94031921	2	4	200	1	0	0	0	0	0	0	0	1	6811	912	32	2		2	GRID2	4	94031921	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	10061489	94031921	97122355	42	36652											
DKK2	27123	broad.mit.edu	37	chr4	107956552	107956552	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaggtttttgcccttcttaCtgccgccgaatgccagtcct	5	13	8	15	2	1	0	0	0	1	0	2	1	2	0	6	1	4	1	6	1	2	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr4:107956552C>G	uc003hyi.2	-	1	902	c.197G>C	c.(196-198)AGT>ACT	p.S66T	DKK2_uc010ilw.1_Intron|DKK2_uc003hyj.1_Missense_Mutation_p.S66T	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	66					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GCCCTTCTTACTGCCGCCGAA	0.577													14	34					0	0	0	0	G	107956552	G	G	107956552	3	3	200	1	0	0	0	0	1	0	0	0	4567	565	20	4	598	4	DKK2	4	107956552	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	13924631	107956552	83197724	43	36653											
PCDH10	57575	broad.mit.edu	37	chr4	134072702	134072702	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagccagccggtctacgaCgtgtatgtgactgaaaacaa	12	9	10	10	3	2	2	1	2	1	0	2	3	2	2	2	1	4	1	2	1	5	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr4:134072702C>T	uc003iha.2	+	1	2233	c.1407C>T	c.(1405-1407)GAC>GAT	p.D469D	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.D469D	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	469	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CGGTCTACGACGTGTATGTGA	0.622													31	63					0	0	0	0	T	134072702	T	T	134072702	2	4	200	1	0	0	0	0	0	0	0	1	11561	535	19	1		1	PCDH10	4	134072702	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	26116150	134072702	57081574	44	36654											
STOX2	56977	broad.mit.edu	37	chr4	184931970	184931970	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caaggaggagtcaccaaaagGgccgggtgggggccccgctg	9	3	18	11	2	1	0	1	0	0	0	1	2	1	2	4	6	0	1	4	6	3	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr4:184931970G>A	uc003ivz.1	+	3	3414	c.1979G>A	c.(1978-1980)GGG>GAG	p.G660E	STOX2_uc003iwa.1_Missense_Mutation_p.G349E	NM_020225	NP_064610	Q9P2F5	STOX2_HUMAN	storkhead box 2	660					embryo development|maternal placenta development						0		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		TCACCAAAAGGGCCGGGTGGG	0.642													5	13					0	0	0	0	A	184931970	A	A	184931970	3	1	200	1	0	0	0	0	1	0	0	0	15386	1232	43	4	1989	4	STOX2	4	184931970	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	50859268	184931970	6222306	45	36655											
ADAMTS16	170690	broad.mit.edu	37	chr5	5237176	5237176	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgggactccatgctcggaGgatagccgtaatgtttgtat	9	12	13	7	2	0	0	0	0	0	0	2	4	1	3	2	3	2	4	2	3	3	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr5:5237176G>A	uc003jdl.2	+	14	2256	c.2118G>A	c.(2116-2118)GAG>GAA	p.E706E	ADAMTS16_uc003jdk.1_Silent_p.E706E|ADAMTS16_uc010itk.1_Intron	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	706	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CATGCTCGGAGGATAGCCGTA	0.284													36	60					0	0	0	0	A	5237176	A	A	5237176	2	1	200	1	0	0	0	0	0	0	0	1	261	991	35	4		4	ADAMTS16	5	5237176	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08		5237176	175678084	46	36656											
DNAH5	1767	broad.mit.edu	37	chr5	13769209	13769209	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctcagccttgaccttttCagcagcctgtgctttcattg	6	15	7	13	0	3	1	3	1	0	0	3	1	3	1	4	0	5	2	4	0	1	6			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr5:13769209C>T	uc003jfd.2	-	58	9799	c.9757G>A	c.(9757-9759)GAA>AAA	p.E3253K	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3253	Stalk (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTGACCTTTTCAGCAGCCTGT	0.428									Kartagener_syndrome				102	260					0	0	0	0	T	13769209	T	T	13769209	3	4	200	1	0	0	0	0	1	0	0	0	4626	835	29	2	4205	2	DNAH5	5	13769209	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	8532033	13769209	167146051	47	36657											
DNAJC21	134218	broad.mit.edu	37	chr5	34945007	34945007	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtcaaagaagcatcgggAaatggtggccttgctaaaac	15	7	12	7	1	1	1	1	0	0	1	2	3	1	2	1	3	3	2	1	3	6	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr5:34945007A>G	uc003jjc.2	+	8	1246	c.1019A>G	c.(1018-1020)GAA>GGA	p.E340G	DNAJC21_uc003jjb.2_Missense_Mutation_p.E340G|DNAJC21_uc010iuu.1_Missense_Mutation_p.E224G|DNAJC21_uc003jjd.2_5'Flank	NM_001012339	NP_001012339	Q5F1R6	DJC21_HUMAN	DnaJ homology subfamily A member 5 isoform 2	340	Glu-rich.				protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|skin(1)	2	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			AAGCATCGGGAAATGGTGGCC	0.408													115	137					0	0	0	0	G	34945007	G	G	34945007	3	3	200	1	0	0	0	0	1	0	0	0	4662	246	9	5	1049	5	DNAJC21	5	34945007	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08	21175798	34945007	145970253	48	36658											
WDR70	55100	broad.mit.edu	37	chr5	37480011	37480011	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctggaagctctcaggccaaGgtgattgacagagatggttt	10	11	13	7	0	2	3	1	2	2	1	3	5	2	4	1	4	1	2	1	4	2	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr5:37480011G>A	uc003jkv.2	+	8	820	c.762G>A	c.(760-762)AAG>AAA	p.K254K	WDR70_uc010iva.1_Silent_p.K254K	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	254	WD 2.							p.K254M(1)		ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTCAGGCCAAGGTGATTGACA	0.383													19	106					0	0	0	0	A	37480011	A	A	37480011	2	1	200	1	0	0	0	0	0	0	0	1	17389	991	35	4		4	WDR70	5	37480011	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	2535004	37480011	143435249	49	36659											
HEATR7B2	133558	broad.mit.edu	37	chr5	41054880	41054880	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcttacttttgtactgaGatcacccatgacgattttga	9	17	6	9	1	2	3	1	3	1	1	3	5	2	3	1	0	2	1	1	0	2	7			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr5:41054880G>T	uc003jmj.3	-	11	1586	c.1096C>A	c.(1096-1098)CTC>ATC	p.L366I	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	366							binding			ovary(6)|central_nervous_system(2)	8						TTTGTACTGAGATCACCCATG	0.363													39	74					3.09479e-21	9.57665e-21	1	0	T	41054880	T	T	41054880	3	4	200	1	0	0	0	0	1	0	0	0	7074	942	33	2	3789	2	HEATR7B2	5	41054880	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	3574869	41054880	139860380	50	36660											
PDE8B	8622	broad.mit.edu	37	chr5	76714063	76714063	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatatcccagggaagcctcGatcagttggatgaggtggca	10	8	13	10	1	1	1	1	1	0	0	3	4	2	3	3	4	1	2	3	4	2	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr5:76714063G>A	uc003kfa.2	+	18	1966	c.1921G>A	c.(1921-1923)GAT>AAT	p.D641N	PDE8B_uc003kfb.2_Missense_Mutation_p.D621N|PDE8B_uc003kfc.2_Missense_Mutation_p.D586N|PDE8B_uc003kfd.2_Missense_Mutation_p.D594N|PDE8B_uc003kfe.2_Missense_Mutation_p.D544N	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	641	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GGGAAGCCTCGATCAGTTGGA	0.577													11	24					0	0	0	0	A	76714063	A	A	76714063	3	1	200	1	0	0	0	0	1	0	0	0	11708	1058	37	1	1991	1	PDE8B	5	76714063	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	35659183	76714063	104201197	51	36661											
TGFBI	7045	broad.mit.edu	37	chr5	135383029	135383029	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccaacggggtggtgcacCtcatcgataaggtcatctcc	10	8	10	13	2	3	0	2	0	1	0	5	1	3	0	3	4	3	1	3	4	3	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr5:135383029C>T	uc003lbf.3	+	6	852	c.691C>T	c.(691-693)CTC>TTC	p.L231F	TGFBI_uc003lbg.3_5'UTR|TGFBI_uc003lbh.3_Missense_Mutation_p.L57F|TGFBI_uc011cyb.1_Missense_Mutation_p.L57F|TGFBI_uc010jed.2_5'Flank	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	231	FAS1 1.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTGGTGCACCTCATCGATAA	0.547													77	74					0	0	0	0	T	135383029	T	T	135383029	3	4	200	1	0	0	0	0	1	0	0	0	15886	681	24	4	713	4	TGFBI	5	135383029	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	58668966	135383029	45532231	52	36662											
ODZ2	57451	broad.mit.edu	37	chr5	167552005	167552005	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcacgtacctgcctgacaCgggcctctgcagctgcgatc	6	8	12	15	3	1	1	0	1	1	0	2	2	1	1	3	2	5	4	3	2	1	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr5:167552005C>T	uc010jjd.2	+	11	2159	c.2159C>T	c.(2158-2160)ACG>ATG	p.T720M	ODZ2_uc003lzr.3_Missense_Mutation_p.T488M|ODZ2_uc003lzt.3_Missense_Mutation_p.T84M|ODZ2_uc010jje.2_Translation_Start_Site|uc003lzs.1_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CTGCCTGACACGGGCCTCTGC	0.612													4	8					0	0	0	0	T	167552005	T	T	167552005	3	4	200	1	0	0	0	0	1	0	0	0	10889	536	19	1	2201	1	ODZ2	5	167552005	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	32168976	167552005	13363255	53	36663											
NSD1	64324	broad.mit.edu	37	chr5	176673717	176673717	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaagccaaggaagcgaaaaCgacagaggcatgctgcagcc	16	2	12	11	2	0	1	0	0	0	1	0	4	0	2	2	2	6	3	2	2	5	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr5:176673717C>T	uc003mfr.3	+	10	4555	c.4417C>T	c.(4417-4419)CGA>TGA	p.R1473*	NSD1_uc003mft.3_Nonsense_Mutation_p.R1204*|NSD1_uc003mfs.1_Nonsense_Mutation_p.R1370*|NSD1_uc011dfx.1_Nonsense_Mutation_p.R1121*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1473					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GAAGCGAAAACGACAGAGGCA	0.423			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			33	24					0	0	0	0	T	176673717	T	T	176673717	4	4	200	1	0	0	0	0	0	1	0	0	10723	528	19	1	4451	1	NSD1	5	176673717	Nonsense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	9121712	176673717	4241543	54	36664											
RANBP9	10048	broad.mit.edu	37	chr6	13639954	13639954	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatcgtacttcactatctgTaccattcaccatttctataa	12	15	2	12	1	4	0	2	0	2	0	5	0	4	0	2	0	2	2	2	0	5	8			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr6:13639954T>C	uc003nbb.2	-	9	1425	c.1366A>G	c.(1366-1368)ACA>GCA	p.T456A	RANBP9_uc003nba.2_Missense_Mutation_p.T115A	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	456	CTLH.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			TCACTATCTGTACCATTCACC	0.388													11	31					0	0	0	0	C	13639954	C	C	13639954	3	2	200	1	0	0	0	0	1	0	0	0	13097	1638	57	5	847	5	RANBP9	6	13639954	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08		13639954	157475113	55	36665											
HIST1H4C	8364	broad.mit.edu	37	chr6	26104071	26104072	+	5'Flank	INS	-	AAA	AAA																															ccacttggtgaccaaatttgINSaaaaaaaaaaaaaaccgcgc																								rs66884675		TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr6:26104071_26104072insAAA	uc003ngi.2	+							NM_003542	NP_003533	P62805	H4_HUMAN	histone cluster 1, H4c						CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						GACCAAATTTGAAAAAAAAAAA	0.416													---	---	---								AAA	26104072	AAA	AAA	26104071	6	5	200	0	1	1	1	0	0	0	0	0	7206	1305	45	0		0	HIST1H4C	6	26104071	5'Flank	INS	-	TCGA-CV-6941-01A-11D-1912-08	12464117	26104071	145010996	56	36666											
EHMT2	10919	broad.mit.edu	37	chr6	31855962	31855962	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagcatcctccccacagtggGgacagaagaccatcccattc	12	6	8	15	0	0	2	0	0	0	2	4	3	3	3	5	2	1	1	5	2	2	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr6:31855962G>A	uc003nxz.1	-	13	1611	c.1601C>T	c.(1600-1602)CCC>CTC	p.P534L	EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Missense_Mutation_p.P325L|EHMT2_uc011don.1_Missense_Mutation_p.P557L|EHMT2_uc003nya.1_Missense_Mutation_p.P500L	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	534					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CCCACAGTGGGGACAGAAGAC	0.652													9	37					0	0	0	0	A	31855962	A	A	31855962	3	1	200	1	0	0	0	0	1	0	0	0	5006	1232	43	4	2095	4	EHMT2	6	31855962	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	5751891	31855962	139259105	57	36667											
ZBTB9	221504	broad.mit.edu	37	chr6	33423997	33423997	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcatgggcctgtgaagctaGgggggacaccccctgcagat	8	7	15	11	0	0	2	0	1	0	1	0	3	0	3	3	4	3	3	3	4	2	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr6:33423997G>A	uc003oeq.2	+	2	1388	c.1120G>A	c.(1120-1122)GGG>AGG	p.G374R		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	374	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTGAAGCTAGGGGGGACACC	0.587													10	19					0	0	0	0	A	33423997	A	A	33423997	3	1	200	1	0	0	0	0	1	0	0	0	17625	1000	35	4	1122	4	ZBTB9	6	33423997	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	1568035	33423997	137691070	58	36668											
PACSIN1	29993	broad.mit.edu	37	chr6	34499414	34499414	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggccagccctacgccaccGagtggtcagacgacgagagt	10	4	14	13	4	1	2	1	0	0	2	1	6	1	2	4	2	2	0	4	2	1	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr6:34499414G>A	uc003ojo.2	+	9	1281	c.1075G>A	c.(1075-1077)GAG>AAG	p.E359K	PACSIN1_uc003ojp.2_Missense_Mutation_p.E359K	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	359					endocytosis		protein kinase activity				0						CTACGCCACCGAGTGGTCAGA	0.647													34	121					0	0	0	0	A	34499414	A	A	34499414	3	1	200	1	0	0	0	0	1	0	0	0	11428	1059	37	1	1105	1	PACSIN1	6	34499414	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	1075417	34499414	136615653	59	36669											
DAAM2	23500	broad.mit.edu	37	chr6	39859202	39859202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggatggcccgtgctgaccGcttcctctatgaaatgagca	8	9	12	12	3	1	3	0	3	1	0	2	4	2	4	3	2	2	3	3	2	2	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr6:39859202G>A	uc003oow.2	+	18	2387	c.2231G>A	c.(2230-2232)CGC>CAC	p.R744H	DAAM2_uc003oox.2_Missense_Mutation_p.R744H	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	744	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CGTGCTGACCGCTTCCTCTAT	0.577													4	12					0	0	0	0	A	39859202	A	A	39859202	3	1	200	1	0	0	0	0	1	0	0	0	4233	1087	38	1	2297	1	DAAM2	6	39859202	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	5359788	39859202	131255865	60	36670											
TRERF1	55809	broad.mit.edu	37	chr6	42196333	42196333	+	Frame_Shift_Del	DEL	T	-	-																															caaaagccgccttctgagccTtttgcctctgttgttcctcc																										TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr6:42196333delT	uc003osd.2	-	18	3916	c.3353delA	c.(3352-3354)AAGfs	p.K1118fs	TRERF1_uc011duq.1_Frame_Shift_Del_p.K1035fs|TRERF1_uc003osb.2_Frame_Shift_Del_p.K886fs|TRERF1_uc003osc.2_Frame_Shift_Del_p.K874fs|TRERF1_uc003ose.2_Frame_Shift_Del_p.K1138fs	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1118	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTGAGCCTTTTGCCTCTG	0.542													---	---	---								-	42196333	-	-	42196333	7	5	200	1	0	1	0	1	0	0	0	0	16542	1609	56	0	253	0	TRERF1	6	42196333	Frame_Shift_Del	DEL	T	TCGA-CV-6941-01A-11D-1912-08	2337131	42196333	128918734	61	36671											
SYNE1	23345	broad.mit.edu	37	chr6	152527463	152527463	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctccacagtcaggatgtagCtgccttgttgccgcagaaac	9	9	10	13	1	1	1	1	0	0	1	2	2	2	2	4	1	4	4	4	1	2	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr6:152527463C>G	uc010kiw.2	-	126	23461	c.22859G>C	c.(22858-22860)AGC>ACC	p.S7620T	SYNE1_uc010kiv.2_Missense_Mutation_p.S2144T|SYNE1_uc003qos.3_Missense_Mutation_p.S2144T|SYNE1_uc003qot.3_Missense_Mutation_p.S7549T|SYNE1_uc003qou.3_Missense_Mutation_p.S7620T|SYNE1_uc003qor.3_Missense_Mutation_p.S520T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7620	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGGATGTAGCTGCCTTGTTG	0.478										HNSCC(10;0.0054)			9	40					0	0	0	0	G	152527463	G	G	152527463	3	3	200	1	0	0	0	0	1	0	0	0	15511	797	28	4	3691	4	SYNE1	6	152527463	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	110331130	152527463	18587604	62	36672											
PMS2	5395	broad.mit.edu	37	chr7	6045547	6045547	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attagtggcaccagcatccaGactgttttctactaactcct	10	13	6	12	0	1	1	0	0	1	1	3	1	3	1	3	1	3	3	3	1	3	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr7:6045547G>A	uc003spl.2	-	2	226	c.139C>T	c.(139-141)CTG>TTG	p.L47L	PMS2_uc003spj.2_5'Flank|PMS2_uc003spk.2_5'UTR|PMS2_uc011jwl.1_Intron|PMS2_uc010ktg.2_5'UTR|PMS2_uc010kte.2_Silent_p.L47L|PMS2_uc010ktf.1_Silent_p.L47L	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	47					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CCAGCATCCAGACTGTTTTCT	0.413			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				69	336					0	0	0	0	A	6045547	A	A	6045547	2	1	200	1	0	0	0	0	0	0	0	1	12198	933	33	2		2	PMS2	7	6045547	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08		6045547	153093116	63	36673											
ABCB5	340273	broad.mit.edu	37	chr7	20683197	20683197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgaagggctggaaactcaCcctagtgactctatccacgt	10	9	11	11	1	2	2	1	2	1	0	3	3	3	3	2	3	1	1	2	3	4	2	rs138449195	by1000genomes	TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr7:20683197C>T	uc010kuh.2	+	7	857	c.620C>T	c.(619-621)ACC>ATC	p.T207I		NM_001163941	NP_001157413	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	393	Helical; (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TGGAAACTCACCCTAGTGACT	0.443													32	44					0	0	0	0	T	20683197	T	T	20683197	3	4	200	1	0	0	0	0	1	0	0	0	44	507	18	4	642	4	ABCB5	7	20683197	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	14637650	20683197	138455466	64	36674											
DNAH11	8701	broad.mit.edu	37	chr7	21940799	21940799	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggccccagctacatctggaCcttcaggctgaagagcgaag	11	6	12	12	1	2	2	1	1	1	1	2	4	2	3	3	3	3	2	3	3	3	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr7:21940799C>T	uc003svc.2	+	83	13530	c.13499C>T	c.(13498-13500)ACC>ATC	p.T4500I	CDCA7L_uc003sve.3_3'UTR|CDCA7L_uc010kuk.2_3'UTR|CDCA7L_uc010kul.2_3'UTR|CDCA7L_uc003svf.3_3'UTR	NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4500					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TACATCTGGACCTTCAGGCTG	0.512									Kartagener_syndrome				21	41					0	0	0	0	T	21940799	T	T	21940799	3	4	200	1	0	0	0	0	1	0	0	0	4621	507	18	4	13826	4	DNAH11	7	21940799	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	1257602	21940799	137197864	65	36675											
OGDH	4967	broad.mit.edu	37	chr7	44739836	44739836	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaacttcttccacgtgctaCgacgccagatcctgctgcca	8	9	8	16	3	1	1	0	0	1	1	3	2	3	1	4	0	5	3	4	0	2	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr7:44739836C>A	uc003tln.2	+	19	2636	c.2527C>A	c.(2527-2529)CGA>AGA	p.R843R	OGDH_uc011kbx.1_Silent_p.R839R|OGDH_uc011kby.1_Silent_p.R693R|OGDH_uc003tlp.2_Silent_p.R854R|OGDH_uc011kbz.1_Silent_p.R638R	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	843					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	CCACGTGCTACGACGCCAGAT	0.572													20	85					4.35082e-09	1.28222e-08	1	0	A	44739836	A	A	44739836	2	1	200	1	0	0	0	0	0	0	0	1	10893	528	19	3		3	OGDH	7	44739836	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	22799037	44739836	114398827	66	36676											
ZNF107	51427	broad.mit.edu	37	chr7	64166756	64166756	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagcagaacataaaagattCtttccagaaagtgacactga	18	8	8	7	0	1	6	0	2	1	4	2	6	2	6	1	0	2	1	1	0	4	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr7:64166756C>T	uc003ttd.2	+	7	860	c.74C>T	c.(73-75)TCT>TTT	p.S25F	ZNF107_uc003tte.2_Missense_Mutation_p.S25F	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	25					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				ATAAAAGATTCTTTCCAGAAA	0.358													33	33					0	0	0	0	T	64166756	T	T	64166756	3	4	200	1	0	0	0	0	1	0	0	0	17782	913	32	2	80	2	ZNF107	7	64166756	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	19426920	64166756	94971907	67	36677											
RUNDC3B	154661	broad.mit.edu	37	chr7	87459335	87459343	+	In_Frame_Del	DEL	CTCCATCCT	-	-																															gatgacaagtccaggcctaaCtccatcctgaaaatttttgt																										TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr7:87459335_87459343delCTCCATCCT	uc003ujb.2	+	12	1823_1831	c.1412_1420delCTCCATCCT	c.(1411-1422)ACTCCATCCTGA>AGA	p.471_474TPS*>R	RUNDC3B_uc011khe.1_In_Frame_Del_p.454_457TPS*>R|RUNDC3B_uc003ujc.2_In_Frame_Del_p.405_408TPS*>R|RUNDC3B_uc003ujd.2_In_Frame_Del_p.327_330TPS*>R	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	471_474										skin(1)	1	Esophageal squamous(14;0.00164)					CCAGGCCTAACTCCATCCTGAAAATTTTT	0.354													---	---	---								-	87459343	-	-	87459335	7	5	200	1	0	1	0	1	0	0	0	0	13810	565	20	0	1458	0	RUNDC3B	7	87459335	In_Frame_Del	DEL	CTCCATCCT	TCGA-CV-6941-01A-11D-1912-08	23292579	87459335	71679328	68	36678											
ANKIB1	54467	broad.mit.edu	37	chr7	92015905	92015905	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggttattacagatgtactcGctatgaagtcattcaacacg	13	12	8	8	2	2	2	2	1	0	1	3	2	2	2	0	1	3	3	0	1	6	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr7:92015905G>A	uc003ulw.2	+	12	2076	c.1700G>A	c.(1699-1701)CGC>CAC	p.R567H	ANKIB1_uc010lew.1_5'UTR	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	567							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGATGTACTCGCTATGAAGTC	0.423													17	14					0	0	0	0	A	92015905	A	A	92015905	3	1	200	1	0	0	0	0	1	0	0	0	630	1087	38	1	1742	1	ANKIB1	7	92015905	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	4556570	92015905	67122758	69	36679											
SLC26A5	375611	broad.mit.edu	37	chr7	103018069	103018069	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccagagttttcactccaaCagaatcaataaaattgactt	15	12	5	9	0	2	3	2	1	0	2	3	3	3	3	2	0	2	1	2	0	5	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr7:103018069C>A	uc003vbz.2	-	18	2199	c.1963G>T	c.(1963-1965)GTT>TTT	p.V655F	SLC26A5_uc003vbt.1_Missense_Mutation_p.V655F|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.V623F|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	655	Cytoplasmic (Potential).|STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TTCACTCCAACAGAATCAATA	0.438													13	58					4.3838e-07	1.27176e-06	1	0	A	103018069	A	A	103018069	3	1	200	1	0	0	0	0	1	0	0	0	14584	478	17	4	324	4	SLC26A5	7	103018069	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	11002164	103018069	56120594	70	36680											
ZC3HAV1	56829	broad.mit.edu	37	chr7	138738294	138738294	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cggcttgtcgcataaaatagGagttttccttcttccttcat	8	16	7	10	2	2	0	1	0	1	0	5	1	4	1	2	2	0	3	2	2	3	8			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr7:138738294G>A	uc003vun.2	-	12	2740	c.2352C>T	c.(2350-2352)CTC>CTT	p.L784L		NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	784	PARP catalytic.				response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						CATAAAATAGGAGTTTTCCTT	0.383													18	39					0	0	0	0	A	138738294	A	A	138738294	2	1	200	1	0	0	0	0	0	0	0	1	17642	1161	41	2		2	ZC3HAV1	7	138738294	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	35720225	138738294	20400369	71	36681											
PRKAG2	51422	broad.mit.edu	37	chr7	151372597	151372597	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaacctctgccctgtgtccGggggggaagacgaggcatag	9	6	16	10	2	1	2	0	0	1	2	2	4	2	3	3	4	2	1	3	4	3	1	rs41317142		TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr7:151372597G>T	uc003wkk.2	-	4	1204	c.593C>A	c.(592-594)CCG>CAG	p.P198Q	PRKAG2_uc011kvl.1_Missense_Mutation_p.P74Q|PRKAG2_uc003wkj.2_Missense_Mutation_p.P154Q|PRKAG2_uc010lqe.1_RNA|PRKAG2_uc003wkm.1_Missense_Mutation_p.P198Q	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	198					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CCCTGTGTCCGGGGGGGAAGA	0.582													4	73					0.000602214	0.00166882	1	0	T	151372597	T	T	151372597	3	4	200	1	0	0	0	0	1	0	0	0	12563	1116	39	3	1168	3	PRKAG2	7	151372597	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	12634303	151372597	7766066	72	36682											
ZNF596	169270	broad.mit.edu	37	chr8	195353	195353	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaatgtaaatcatatggaaGtcatctatttgattatgcct	14	15	6	6	0	3	1	2	1	1	0	3	2	3	2	1	1	1	1	1	1	7	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr8:195353G>A	uc003wot.2	+	6	794	c.506G>A	c.(505-507)AGT>AAT	p.S169N	ZNF596_uc003wou.2_Missense_Mutation_p.S68N|ZNF596_uc003wov.2_Missense_Mutation_p.S169N|ZNF596_uc003wow.2_Missense_Mutation_p.S169N	NM_173539	NP_775810	Q8TC21	ZN596_HUMAN	zinc finger protein 596	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)		TCATATGGAAGTCATCTATTT	0.373													18	29					0	0	0	0	A	195353	A	A	195353	3	1	200	1	0	0	0	0	1	0	0	0	18093	1029	36	4	524	4	ZNF596	8	195353	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08		195353	146168669	73	36683											
DLC1	10395	broad.mit.edu	37	chr8	13356766	13356766	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaggcagcttccaaaatctGtttttaataatggcagtcct	12	13	8	8	0	1	0	0	0	1	0	3	1	3	0	2	2	1	4	2	2	5	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr8:13356766G>A	uc003wwm.2	-	2	1259	c.815C>T	c.(814-816)ACA>ATA	p.T272I	DLC1_uc003wwn.2_Missense_Mutation_p.T272I|DLC1_uc011kxy.1_Missense_Mutation_p.T272I	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	272					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TCCAAAATCTGTTTTTAATAA	0.428													15	153					0	0	0	0	A	13356766	A	A	13356766	3	1	200	1	0	0	0	0	1	0	0	0	4572	1377	48	4	3924	4	DLC1	8	13356766	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	13161413	13356766	133007256	74	36684											
ARFGEF1	10565	broad.mit.edu	37	chr8	68130079	68130079	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagttttatcccagatttcTagggtaaatttttcaccatt	11	17	5	8	0	2	1	1	0	1	1	3	1	3	1	2	1	0	2	2	1	5	8	rs145845893	byFrequency	TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr8:68130079T>C	uc003xxo.1	-	32	4941	c.4551A>G	c.(4549-4551)CTA>CTG	p.L1517L	ARFGEF1_uc003xxl.1_Silent_p.L971L|ARFGEF1_uc003xxn.1_Silent_p.L500L	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1517					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CCCAGATTTCTAGGGTAAATT	0.343													26	33					0	0	0	0	C	68130079	C	C	68130079	2	2	200	1	0	0	0	0	0	0	0	1	852	1509	53	5		5	ARFGEF1	8	68130079	Silent	SNP	T	TCGA-CV-6941-01A-11D-1912-08	54773313	68130079	78233943	75	36685											
ZNF517	340385	broad.mit.edu	37	chr8	146033063	146033063	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctggctgcccaccaccgcgtCcacacccgcgagcggcccta	6	4	10	21	5	0	0	0	0	0	0	1	1	1	0	6	2	2	1	6	2	1	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr8:146033063C>T	uc003zed.1	+	5	869	c.762C>T	c.(760-762)GTC>GTT	p.V254V	ZNF517_uc010mgd.1_Silent_p.V160V|ZNF517_uc003zee.1_RNA|ZNF517_uc011llm.1_Silent_p.V160V|ZNF517_uc003zef.1_Intron	NM_213605	NP_998770	Q6ZMY9	ZN517_HUMAN	zinc finger protein 517	254	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)			ACCACCGCGTCCACACCCGCG	0.692													10	16					0	0	0	0	T	146033063	T	T	146033063	2	4	200	1	0	0	0	0	0	0	0	1	18028	842	30	2		2	ZNF517	8	146033063	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	77902984	146033063	330959	76	36686											
ZNF16	7564	broad.mit.edu	37	chr8	146157090	146157090	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggtgtttgatgaggtttgaGcttcgcctgaaggccttccc	5	14	13	9	1	0	4	0	4	0	0	2	4	1	4	3	3	1	3	3	3	1	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr8:146157090G>A	uc003zet.2	-	4	1270	c.1083C>T	c.(1081-1083)AGC>AGT	p.S361S	ZNF16_uc003zeu.2_Silent_p.S361S	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	361	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		TGAGGTTTGAGCTTCGCCTGA	0.522													25	47					0	0	0	0	A	146157090	A	A	146157090	2	1	200	1	0	0	0	0	0	0	0	1	17805	962	34	4		4	ZNF16	8	146157090	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	124027	146157090	206932	77	36687											
CDKN2A	1029	broad.mit.edu	37	chr9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcagctccgccactcGggcgctgcccatcatcatga	8	6	10	17	3	2	1	2	1	0	0	4	1	3	1	3	1	4	4	3	1	0	0	rs121913387		TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			5	5					0	0	0	0	A	21971186	A	A	21971186	4	1	200	1	0	0	0	0	0	1	0	0	3176	1125	39	1	306	1	CDKN2A	9	21971186	Nonsense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08		21971186	119242245	78	36688											
MAMDC2	256691	broad.mit.edu	37	chr9	72723128	72723128	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgttcctttctctttccaggCcattacatttatgtggatac	7	18	6	10	0	1	0	0	0	1	0	4	1	3	1	3	2	2	1	3	2	3	7			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr9:72723128C>T	uc004ahm.2	+	3	767	c.150C>T	c.(148-150)GGC>GGT	p.G50G	MAMDC2_uc004ahn.2_RNA	NM_153267	NP_694999	Q7Z304	MAMC2_HUMAN	MAM domain containing 2 precursor	50	MAM 1.					endoplasmic reticulum|membrane				central_nervous_system(1)|pancreas(1)	2						TCTTTCCAGGCCATTACATTT	0.448													8	51					0	0	0	0	T	72723128	T	T	72723128	2	4	200	1	0	0	0	0	0	0	0	1	9256	753	26	4		4	MAMDC2	9	72723128	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	50751942	72723128	68490303	79	36689											
FLJ46321	389763	broad.mit.edu	37	chr9	84607724	84607724	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatacagccaggagactgTcccaaaagatcacctgttgc	12	7	11	11	0	1	2	1	0	0	2	2	4	2	3	3	2	3	1	3	2	3	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr9:84607724T>C	uc004amn.2	+	4	2386	c.2339T>C	c.(2338-2340)GTC>GCC	p.V780A		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	780						integral to membrane					0						CAGGAGACTGTCCCAAAAGAT	0.473													30	42					0	0	0	0	C	84607724	C	C	84607724	3	2	200	1	0	0	0	0	1	0	0	0	5964	1667	58	5	2353	5	FLJ46321	9	84607724	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	11884596	84607724	56605707	80	36690											
WNK2	65268	broad.mit.edu	37	chr9	96051365	96051365	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggagactcacgaggccccGcttgctgtgcagcccctcgt	5	7	13	16	4	1	1	1	0	0	1	2	3	1	1	4	2	3	3	4	2	0	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr9:96051365G>A	uc004ati.1	+	20	4440	c.4440G>A	c.(4438-4440)CCG>CCA	p.P1480P	WNK2_uc011lud.1_Silent_p.P1443P|WNK2_uc004atj.2_Silent_p.P1443P|WNK2_uc004atk.2_Silent_p.P1080P|WNK2_uc004atl.1_Silent_p.P38P	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1480					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						ACGAGGCCCCGCTTGCTGTGC	0.677													8	0					0	0	0	0	A	96051365	A	A	96051365	2	1	200	1	0	0	0	0	0	0	0	1	17446	1074	38	1		1	WNK2	9	96051365	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	11443641	96051365	45162066	81	36691											
FANCC	2176	broad.mit.edu	37	chr9	98011545	98011545	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatccaaaactgataatcaCaagaaagatctactgaatct	18	9	5	9	0	3	4	1	2	2	2	4	4	4	4	1	0	2	1	1	0	7	2	rs143152201	byFrequency	TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr9:98011545C>T	uc004avh.2	-	2	291	c.29G>A	c.(28-30)TGT>TAT	p.C10Y	FANCC_uc004avi.3_Missense_Mutation_p.C10Y|FANCC_uc010mrm.1_RNA|FANCC_uc011lul.1_RNA	NM_000136	NP_000127	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	10					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)	1		Acute lymphoblastic leukemia(62;0.138)				CTGATAATCACAAGAAAGATC	0.478			D|Mis|N|F|S			AML|leukemia		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				16	9					0	0	0	0	T	98011545	T	T	98011545	3	4	200	1	0	0	0	0	1	0	0	0	5696	478	17	4	1703	4	FANCC	9	98011545	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	1960180	98011545	43201886	82	36692											
TEX10	54881	broad.mit.edu	37	chr9	103092287	103092287	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttgcttactatttagcctaGagccatcttcaagggtctct	8	15	8	10	0	3	1	1	0	2	1	4	1	3	1	2	1	4	2	2	1	5	7			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr9:103092287G>C	uc004bas.2	-	6	1630	c.1415C>G	c.(1414-1416)TCT>TGT	p.S472C	TEX10_uc011lvf.1_Missense_Mutation_p.S311C|TEX10_uc011lvg.1_Missense_Mutation_p.S475C|TEX10_uc011lvh.1_Missense_Mutation_p.S407C	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	472						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		ATTTAGCCTAGAGCCATCTTC	0.423													49	43					0	0	0	0	C	103092287	C	C	103092287	3	2	200	1	0	0	0	0	1	0	0	0	15838	942	33	2	1414	2	TEX10	9	103092287	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	5080742	103092287	38121144	83	36693											
MURC	347273	broad.mit.edu	37	chr9	103348551	103348551	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaggagcgagtctctgggcCccatcagtgagctctactct	7	9	11	14	1	4	1	1	1	3	0	5	3	4	2	3	2	3	1	3	2	1	1	rs148950537		TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr9:103348551C>A	uc004bba.2	+	2	1003	c.913C>A	c.(913-915)CCC>ACC	p.P305T		NM_001018116	NP_001018126	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	305					cell differentiation|muscle organ development|transcription, DNA-dependent					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0461)				GTCTCTGGGCCCCATCAGTGA	0.587													5	62					0.00307968	0.00845015	1	0	A	103348551	A	A	103348551	3	1	200	1	0	0	0	0	1	0	0	0	10040	623	22	4	919	4	MURC	9	103348551	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	256264	103348551	37864880	84	36694											
MEGF9	1955	broad.mit.edu	37	chr9	123476100	123476100	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggacgctgctgttgctgctGctggggagatcgggggtcgg	4	9	20	8	3	0	1	0	0	0	1	2	3	0	2	0	6	4	6	0	6	0	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr9:123476100G>T	uc004bkj.1	-	1	513	c.513C>A	c.(511-513)AGC>AGA	p.S171R	MEGF9_uc011lyb.1_Missense_Mutation_p.S171R|MEGF9_uc004bkk.3_Missense_Mutation_p.S171R	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	179	Extracellular (Potential).|Pro-rich.					integral to membrane	calcium ion binding				0						TGTTGCTGCTGCTGGGGAGAT	0.731													5	32					0.00198382	0.00547023	1	0	T	123476100	T	T	123476100	3	4	200	1	0	0	0	0	1	0	0	0	9517	1310	46	4	1438	4	MEGF9	9	123476100	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	20127549	123476100	17737331	85	36695											
PTGS1	5742	broad.mit.edu	37	chr9	125148893	125148893	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcaccccctcatgcctgactCcttcaaggtgggctcccagg	6	8	10	17	0	2	1	2	1	0	0	4	1	4	1	5	3	1	2	5	3	1	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr9:125148893C>G	uc004bmg.1	+	9	1313	c.1178C>G	c.(1177-1179)TCC>TGC	p.S393C	PTGS1_uc011lys.1_Missense_Mutation_p.S368C|PTGS1_uc010mwb.1_Missense_Mutation_p.S284C|PTGS1_uc004bmf.1_Missense_Mutation_p.S393C|PTGS1_uc004bmh.1_Missense_Mutation_p.S284C|PTGS1_uc011lyt.1_Missense_Mutation_p.S284C	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	393					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	ATGCCTGACTCCTTCAAGGTG	0.552													77	40					0	0	0	0	G	125148893	G	G	125148893	3	3	200	1	0	0	0	0	1	0	0	0	12818	855	30	2	1212	2	PTGS1	9	125148893	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	1672793	125148893	16064538	86	36696											
REXO4	57109	broad.mit.edu	37	chr9	136277920	136277920	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgaaggcctgctctttcaCgaggctgaggctgacgctgc	6	8	14	13	3	2	2	1	2	1	0	2	4	2	2	2	3	2	4	2	3	1	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr9:136277920C>T	uc004cdm.2	-	3	894	c.694G>A	c.(694-696)GTG>ATG	p.V232M	ADAMTS13_uc004cdp.3_5'Flank|REXO4_uc011mde.1_Missense_Mutation_p.V95M|REXO4_uc011mdf.1_Missense_Mutation_p.V95M|REXO4_uc004cdn.2_Translation_Start_Site|REXO4_uc004cdo.2_Intron	NM_020385	NP_065118	Q9GZR2	REXO4_HUMAN	XPMC2 prevents mitotic catastrophe 2 homolog	232						nucleolus	exonuclease activity|nucleic acid binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.58e-08)|Epithelial(140;9.55e-07)|all cancers(34;1.05e-05)		TGCTCTTTCACGAGGCTGAGG	0.627													10	27					0	0	0	0	T	136277920	T	T	136277920	3	4	200	1	0	0	0	0	1	0	0	0	13308	536	19	1	598	1	REXO4	9	136277920	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	11129027	136277920	4935511	87	36697											
DIP2C	22982	broad.mit.edu	37	chr10	412284	412284	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgcaactgcacacacacaCagctccccgatctcatccgt	10	7	6	18	3	1	0	1	0	1	0	5	1	3	0	3	0	3	3	3	0	1	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr10:412284C>G	uc001ifp.2	-	19	2289	c.2199G>C	c.(2197-2199)CTG>CTC	p.L733L	DIP2C_uc009xhi.1_Silent_p.L119L|DIP2C_uc010pzz.1_Silent_p.L54L	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	733						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CACACACACACAGCTCCCCGA	0.542													7	44					0	0	0	0	G	412284	G	G	412284	2	3	200	1	0	0	0	0	0	0	0	1	4551	465	17	4		4	DIP2C	10	412284	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08		412284	135122463	88	36698											
KLF6	1316	broad.mit.edu	37	chr10	3823889	3823889	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttggtgtaaactttcctgCagccgttaaagtggcaccgg	8	13	11	9	2	0	0	0	0	0	0	1	0	1	0	3	3	3	4	3	3	4	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr10:3823889C>T	uc001iha.2	-	2	887	c.620G>A	c.(619-621)TGC>TAC	p.C207Y	KLF6_uc010qaj.1_Missense_Mutation_p.C207Y|KLF6_uc010qak.1_Intron|KLF6_uc010qal.1_Intron|KLF6_uc001ihb.2_Missense_Mutation_p.C207Y	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	207	C2H2-type 1.				B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		AACTTTCCTGCAGCCGTTAAA	0.657											OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	43					0	0	0	0	T	3823889	T	T	3823889	3	4	200	1	0	0	0	0	1	0	0	0	8389	710	25	4	243	4	KLF6	10	3823889	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	3411605	3823889	131710858	89	36699											
C10orf18	54906	broad.mit.edu	37	chr10	5789368	5789368	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaataggtgaaccggaagaGgtggctctcacagaaagcag	15	5	14	7	1	1	3	1	1	1	2	2	5	1	4	1	4	2	2	1	4	5	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr10:5789368G>A	uc001iij.2	+	15	4609	c.3984G>A	c.(3982-3984)GAG>GAA	p.E1328E	C10orf18_uc001iik.2_Silent_p.E172E	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1328										ovary(1)|central_nervous_system(1)	2						AACCGGAAGAGGTGGCTCTCA	0.453													68	140					0	0	0	0	A	5789368	A	A	5789368	2	1	200	1	0	0	0	0	0	0	0	1	1602	991	35	4		4	C10orf18	10	5789368	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	1965479	5789368	129745379	90	36700											
PHYH	5264	broad.mit.edu	37	chr10	13337587	13337587	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctctgttccagggttagaaCgttattatccagagtatacc	10	14	8	9	1	1	2	0	0	1	2	4	2	3	2	3	1	2	4	3	1	6	6			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr10:13337587C>A	uc001imf.2	-	3	242	c.154G>T	c.(154-156)GTT>TTT	p.V52F	PHYH_uc001ime.2_5'UTR|PHYH_uc001img.2_Missense_Mutation_p.V33F	NM_006214	NP_006205	O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase isoform a precursor	52					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding				0		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	AGGGTTAGAACGTTATTATCC	0.264													11	31					3.86212e-05	0.000108101	1	0	A	13337587	A	A	13337587	3	1	200	1	0	0	0	0	1	0	0	0	11919	536	19	3	890	3	PHYH	10	13337587	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	7548219	13337587	122197160	91	36701											
ZNF485	220992	broad.mit.edu	37	chr10	44111790	44111790	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccctaaagcaaagcacttCtgaagcatctgttctgggag	12	9	10	10	0	3	1	0	1	3	0	3	2	3	2	1	1	4	4	1	1	4	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr10:44111790C>T	uc010qfc.1	+	5	493	c.299C>T	c.(298-300)TCT>TTT	p.S100F	ZNF485_uc010qfd.1_Missense_Mutation_p.S9F	NM_145312	NP_660355	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAAAGCACTTCTGAAGCATCT	0.408													7	36					0	0	0	0	T	44111790	T	T	44111790	3	4	200	1	0	0	0	0	1	0	0	0	18005	913	32	2	313	2	ZNF485	10	44111790	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	30774203	44111790	91422957	92	36702											
PCDH15	65217	broad.mit.edu	37	chr10	56287615	56287615	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaactatggtagctggtggTcctcccctagctagtttgca	7	12	11	11	0	0	0	0	0	0	0	2	0	2	0	3	3	4	6	3	3	5	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr10:56287615T>C	uc001jju.1	-	3	509	c.114A>G	c.(112-114)GGA>GGG	p.G38G	PCDH15_uc010qhq.1_Silent_p.G43G|PCDH15_uc010qhr.1_Silent_p.G38G|PCDH15_uc010qhs.1_Silent_p.G43G|PCDH15_uc010qht.1_Silent_p.G38G|PCDH15_uc010qhu.1_Silent_p.G38G|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Silent_p.G38G|PCDH15_uc010qhw.1_Silent_p.G38G|PCDH15_uc010qhx.1_Silent_p.G38G|PCDH15_uc010qhy.1_Silent_p.G43G|PCDH15_uc010qhz.1_Silent_p.G38G|PCDH15_uc010qia.1_Intron|PCDH15_uc010qib.1_Intron|PCDH15_uc001jjw.2_Silent_p.G38G	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	38	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TAGCTGGTGGTCCTCCCCTAG	0.348										HNSCC(58;0.16)			22	22					0	0	0	0	C	56287615	C	C	56287615	2	2	200	1	0	0	0	0	0	0	0	1	11565	1654	58	5		5	PCDH15	10	56287615	Silent	SNP	T	TCGA-CV-6941-01A-11D-1912-08	12175825	56287615	79247132	93	36703											
ANK3	288	broad.mit.edu	37	chr10	61832598	61832598	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggacttgctgtcctcagtctGttgggagagaaccatcttct	7	13	11	10	0	4	1	1	0	3	1	5	4	5	3	2	2	2	2	2	2	1	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr10:61832598G>A	uc001jky.2	-	37	8233	c.8041C>T	c.(8041-8043)CAG>TAG	p.Q2681*	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2681					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TCCTCAGTCTGTTGGGAGAGA	0.542													24	44					0	0	0	0	A	61832598	A	A	61832598	4	1	200	1	0	0	0	0	0	1	0	0	622	1386	48	4	5433	4	ANK3	10	61832598	Nonsense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	5544983	61832598	73702149	94	36704											
CDHR1	92211	broad.mit.edu	37	chr10	85964326	85964326	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgccatggatggagaccgggGcaaacccaatcgaattctct	11	7	11	12	3	1	1	0	0	1	1	3	4	1	2	3	4	1	1	3	4	3	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr10:85964326G>A	uc001kcv.2	+	9	827	c.827G>A	c.(826-828)GGC>GAC	p.G276D	CDHR1_uc001kcw.2_Missense_Mutation_p.G276D|CDHR1_uc009xst.2_Missense_Mutation_p.G35D	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	276	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						GGAGACCGGGGCAAACCCAAT	0.478													31	43					0	0	0	0	A	85964326	A	A	85964326	3	1	200	1	0	0	0	0	1	0	0	0	3133	1203	42	4	861	4	CDHR1	10	85964326	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	24131728	85964326	49570421	95	36705											
GRID1	2894	broad.mit.edu	37	chr10	87614311	87614311	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccaaggatttcaaactggAcatagggattcgaactgtcc	12	10	10	9	1	1	0	1	0	0	0	3	4	2	3	2	3	3	0	2	3	4	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr10:87614311A>T	uc001kdl.1	-	8	1276	c.1175T>A	c.(1174-1176)GTC>GAC	p.V392D	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	392	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TTCAAACTGGACATAGGGATT	0.493										Multiple Myeloma(13;0.14)			11	48					0	0	0	0	T	87614311	T	T	87614311	3	4	200	1	0	0	0	0	1	0	0	0	6810	275	10	5	1890	5	GRID1	10	87614311	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08	1649985	87614311	47920436	96	36706											
GBF1	8729	broad.mit.edu	37	chr10	104136823	104136823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaacatgcctctcggggcGggcagagtgatgatgatgag	9	7	16	9	2	1	5	0	4	1	1	2	5	1	5	2	3	2	1	2	3	1	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr10:104136823G>A	uc001kux.1	+	33	4657	c.4417G>A	c.(4417-4419)GGG>AGG	p.G1473R	GBF1_uc001kuy.1_Missense_Mutation_p.G1473R|GBF1_uc001kuz.1_Missense_Mutation_p.G1474R	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1473					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CTCTCGGGGCGGGCAGAGTGA	0.532													55	71					0	0	0	0	A	104136823	A	A	104136823	3	1	200	1	0	0	0	0	1	0	0	0	6306	1116	39	1	4543	1	GBF1	10	104136823	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	16522512	104136823	31397924	97	36707											
OR51E2	81285	broad.mit.edu	37	chr11	4703255	4703255	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccttggcccgctctgacttGgaaggcagttgcagaaccgt	7	9	13	12	2	1	2	0	1	1	1	1	3	1	3	3	3	2	4	3	3	2	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:4703255G>A	uc001lzk.2	-	2	931	c.687C>T	c.(685-687)TCC>TCT	p.S229S		NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(3)|ovary(2)	5		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GCTCTGACTTGGAAGGCAGTT	0.498													16	49					0	0	0	0	A	4703255	A	A	4703255	2	1	200	1	0	0	0	0	0	0	0	1	11149	1335	47	4		4	OR51E2	11	4703255	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08		4703255	130303261	98	36708											
OR51I2	390064	broad.mit.edu	37	chr11	5474810	5474810	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctggctgtcagggccccTctgcgtgatgtatgctgtgg	3	12	14	12	1	2	1	1	1	1	0	3	1	3	1	3	3	2	3	3	3	1	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:5474810T>G	uc010qzf.1	+	1	92	c.92T>G	c.(91-93)CTC>CGC	p.L31R	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCAGGGCCCCTCTGCGTGATG	0.562													5	43					0	0	0	0	G	5474810	G	G	5474810	3	3	200	1	0	0	0	0	1	0	0	0	11155	1551	54	5	94	5	OR51I2	11	5474810	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	771555	5474810	129531706	99	36709											
PLEKHA7	144100	broad.mit.edu	37	chr11	17035570	17035570	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcgccctcctccgtgaagcCctcctcccagccgcggggca	4	5	12	20	4	0	1	0	1	0	0	4	1	4	1	7	3	2	1	7	3	1	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:17035570C>T	uc001mmo.2	-	3	202	c.187G>A	c.(187-189)GGC>AGC	p.G63S	PLEKHA7_uc010rcu.1_Missense_Mutation_p.G63S	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	63	WW 2.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TCCGTGAAGCCCTCCTCCCAG	0.547													2	1					0	0	0	0	T	17035570	T	T	17035570	3	4	200	1	0	0	0	0	1	0	0	0	12116	623	22	4	3262	4	PLEKHA7	11	17035570	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	11560760	17035570	117970946	100	36710											
PAX6	5080	broad.mit.edu	37	chr11	31823109	31823109	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatgttctcaatgaacttacGcttggtatgttatcgttggt	8	17	10	6	2	1	1	1	1	1	0	3	2	1	1	0	2	2	5	0	2	5	6	rs121907928		TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:31823109G>T	uc001mtd.3	-	5	1247	c.357C>A	c.(355-357)AGC>AGA	p.S119R	PAX6_uc001mte.3_Missense_Mutation_p.S119R|PAX6_uc001mtg.3_Missense_Mutation_p.S133R|PAX6_uc001mtf.3_Missense_Mutation_p.S119R|PAX6_uc001mth.3_Missense_Mutation_p.S119R|PAX6_uc009yjr.2_Missense_Mutation_p.S119R	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	119	Paired.		S -> R (in AN).		blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					ATGAACTTACGCTTGGTATGT	0.512									Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				10	35					2.17888e-05	6.19201e-05	1	0	T	31823109	T	T	31823109	3	4	200	1	0	0	0	0	1	0	0	0	11537	1101	38	3	943	3	PAX6	11	31823109	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	14787539	31823109	103183407	101	36711											
DEPDC7	91614	broad.mit.edu	37	chr11	33054913	33054913	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaactcttgatgaggattCaaaactttctgccaaagaga	17	10	7	7	0	3	3	1	2	2	1	3	5	3	4	1	1	3	0	1	1	5	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:33054913C>T	uc001mub.2	+	9	1540	c.1448C>T	c.(1447-1449)TCA>TTA	p.S483L	DEPDC7_uc001muc.2_Missense_Mutation_p.S474L	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	483					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						GATGAGGATTCAAAACTTTCT	0.338													11	39					0	0	0	0	T	33054913	T	T	33054913	3	4	200	1	0	0	0	0	1	0	0	0	4466	838	29	2	1532	2	DEPDC7	11	33054913	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	1231804	33054913	101951603	102	36712											
PAMR1	25891	broad.mit.edu	37	chr11	35496243	35496243	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagtgagcatttaggggataGctttccaacaaaatctgacc	13	10	9	9	0	1	2	0	2	1	0	2	3	2	3	2	2	3	2	2	2	5	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:35496243G>A	uc001mwg.2	-	4	472	c.429C>T	c.(427-429)AGC>AGT	p.S143S	PAMR1_uc001mwf.2_Silent_p.S143S|PAMR1_uc010rew.1_Intron|PAMR1_uc010rex.1_Silent_p.S103S	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	143	CUB.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						TTAGGGGATAGCTTTCCAACA	0.463													22	55					0	0	0	0	A	35496243	A	A	35496243	2	1	200	1	0	0	0	0	0	0	0	1	11467	962	34	4		4	PAMR1	11	35496243	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	2441330	35496243	99510273	103	36713											
CKAP5	9793	broad.mit.edu	37	chr11	46780912	46780912	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactgtaccattgtcattcTcaatctcatctagatccagc	10	13	6	12	0	4	1	3	0	3	1	7	2	5	2	2	1	2	1	2	1	3	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:46780912T>A	uc001ndi.1	-	34	4585	c.4475A>T	c.(4474-4476)GAG>GTG	p.E1492V	CKAP5_uc009ylg.1_Missense_Mutation_p.E1378V|CKAP5_uc001ndj.1_Missense_Mutation_p.E1492V|CKAP5_uc001ndh.1_Missense_Mutation_p.E421V	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1492					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						ATTGTCATTCTCAATCTCATC	0.493													16	62					0	0	0	0	A	46780912	A	A	46780912	3	1	200	1	0	0	0	0	1	0	0	0	3460	1551	54	5	1667	5	CKAP5	11	46780912	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	11284669	46780912	88225604	104	36714											
FNBP4	23360	broad.mit.edu	37	chr11	47739054	47739054	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaaattagcatttctctCtgccatgccactgtgaaaac	12	13	5	11	0	3	1	1	1	2	0	4	1	3	1	2	0	4	1	2	0	5	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:47739054C>A	uc009ylv.2	-	17	3127	c.2974G>T	c.(2974-2976)GAG>TAG	p.E992*	AGBL2_uc001ngg.2_5'Flank|AGBL2_uc010rhq.1_5'Flank|AGBL2_uc001ngh.1_5'Flank|FNBP4_uc001ngi.2_Nonsense_Mutation_p.E306*|FNBP4_uc001ngj.2_Nonsense_Mutation_p.E899*	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	992										ovary(1)	1						GCATTTCTCTCTGCCATGCCA	0.328													15	37					0.000308642	0.000859568	1	0	A	47739054	A	A	47739054	4	1	200	1	0	0	0	0	0	1	0	0	5999	922	32	2	83	2	FNBP4	11	47739054	Nonsense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	958142	47739054	87267462	105	36715											
OR5T3	390154	broad.mit.edu	37	chr11	56020591	56020591	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accatgacatcatagtgtcaAtattttacacaattgtgatt	14	15	5	7	0	2	2	2	2	0	0	2	2	2	2	1	0	1	0	1	0	5	6			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:56020591A>G	uc010rjd.1	+	1	916	c.916A>G	c.(916-918)ATA>GTA	p.I306V		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	306	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					CATAGTGTCAATATTTTACAC	0.358													14	54					0	0	0	0	G	56020591	G	G	56020591	3	3	200	1	0	0	0	0	1	0	0	0	11237	101	4	5	918	5	OR5T3	11	56020591	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08	8281537	56020591	78985925	106	36716											
SERPING1	710	broad.mit.edu	37	chr11	57367613	57367613	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccaccatccaacccacccaaCcaactacccagctcccaaca	14	3	1	23	0	0	0	0	0	0	0	2	0	2	0	8	0	6	1	8	0	5	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:57367613C>A	uc001nkp.1	+	3	504	c.313C>A	c.(313-315)CCA>ACA	p.P105T	SERPING1_uc001nkq.1_Missense_Mutation_p.P105T|SERPING1_uc010rju.1_Missense_Mutation_p.P53T|SERPING1_uc010rjv.1_Missense_Mutation_p.P110T|SERPING1_uc001nkr.1_Missense_Mutation_p.P105T|SERPING1_uc009ymi.1_Missense_Mutation_p.P105T|SERPING1_uc009ymj.1_Missense_Mutation_p.P105T|SERPING1_uc001nks.1_Intron	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	105	6.|7 X 4 AA tandem repeats of [QE]-P-T-[TQ].		Missing (in HAE; type 2).		blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						acccacccaaccaactaccca	0.154									Hereditary_Angioedema				18	63					3.32936e-07	9.70918e-07	1	0	A	57367613	A	A	57367613	3	1	200	1	0	0	0	0	1	0	0	0	14181	507	18	4	319	4	SERPING1	11	57367613	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	1347022	57367613	77638903	107	36717											
FAM111A	63901	broad.mit.edu	37	chr11	58920865	58920865	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcgtagtatcattgagtttgGctctaccatggaatccatcc	9	14	8	10	1	2	1	1	1	1	0	5	2	4	2	3	2	1	4	3	2	4	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:58920865G>C	uc010rkp.1	+	5	1951	c.1724G>C	c.(1723-1725)GGC>GCC	p.G575A	FAM111A_uc010rkq.1_Missense_Mutation_p.G575A|FAM111A_uc010rkr.1_Missense_Mutation_p.G575A|FAM111A_uc001nno.2_Missense_Mutation_p.G575A|FAM111A_uc001nnp.2_Missense_Mutation_p.G575A|FAM111A_uc001nnq.2_Missense_Mutation_p.G575A	NM_001142521	NP_001135993	Q96PZ2	F111A_HUMAN	hypothetical protein LOC63901	575					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_epithelial(135;0.139)				ATTGAGTTTGGCTCTACCATG	0.403													56	79					0	0	0	0	C	58920865	C	C	58920865	3	2	200	1	0	0	0	0	1	0	0	0	5427	1203	42	4	1730	4	FAM111A	11	58920865	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	1553252	58920865	76085651	108	36718											
RPS6KA4	8986	broad.mit.edu	37	chr11	64137240	64137240	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttcgggttcgcgcggttgCggccgcagagtcccggggtg	3	8	18	12	7	0	1	0	0	0	1	3	1	1	1	2	5	1	3	2	5	0	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:64137240C>T	uc001oae.2	+	14	1755	c.1672C>T	c.(1672-1674)CGG>TGG	p.R558W	RPS6KA4_uc001oad.2_Missense_Mutation_p.R552W|RPS6KA4_uc010rnl.1_Missense_Mutation_p.R495W|RPS6KA4_uc001oaf.2_Missense_Mutation_p.R551W|RPS6KA4_uc009ypp.2_Intron	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	558	Protein kinase 2.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						CGCGCGGTTGCGGCCGCAGAG	0.692													9	14					0	0	0	0	T	64137240	T	T	64137240	3	4	200	1	0	0	0	0	1	0	0	0	13718	759	27	1	1726	1	RPS6KA4	11	64137240	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	5216375	64137240	70869276	109	36719											
MYO7A	4647	broad.mit.edu	37	chr11	76891461	76891461	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaaaatgcggctggcggaGgaagagaagcttcggaagga	14	4	18	5	3	0	2	0	0	0	2	1	8	0	6	0	6	2	2	0	6	5	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:76891461G>A	uc001oyb.2	+	22	2900	c.2628G>A	c.(2626-2628)GAG>GAA	p.E876E	MYO7A_uc010rsl.1_Silent_p.E876E|MYO7A_uc010rsm.1_Silent_p.E865E|MYO7A_uc001oyc.2_Silent_p.E876E|MYO7A_uc001oyd.2_Silent_p.E216E|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Silent_p.E87E	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	876	Potential.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GGCTGGCGGAGGAAGAGAAGC	0.587													5	8					0	0	0	0	A	76891461	A	A	76891461	2	1	200	1	0	0	0	0	0	0	0	1	10135	991	35	4		4	MYO7A	11	76891461	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	12754221	76891461	58115055	110	36720											
CARD17	440068	broad.mit.edu	37	chr11	104970094	104970094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttaaaaacagcattacctagGaaggaagtactatttgagaa	18	10	8	5	0	0	1	0	1	0	1	0	4	0	3	1	2	4	2	1	2	10	6			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr11:104970094G>A	uc001pir.1	-	3	346	c.329C>T	c.(328-330)TCC>TTC	p.S110F	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron	NM_001007232	NP_001007233	Q5XLA6	CAR17_HUMAN	caspase recruitment domain family, member 17	110					proteolysis|regulation of apoptosis	cytoplasm	cysteine-type endopeptidase activity|cysteine-type endopeptidase inhibitor activity			ovary(1)	1						CATTACCTAGGAAGGAAGTAC	0.388													23	32					0	0	0	0	A	104970094	A	A	104970094	3	1	200	1	0	0	0	0	1	0	0	0	2660	1174	41	2	7	2	CARD17	11	104970094	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	28078633	104970094	30036422	111	36721											
CD163L1	283316	broad.mit.edu	37	chr12	7548986	7548986	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcggttgctgccgcccacCagcctcaggccccatgttgc	5	7	11	18	2	1	0	1	0	0	0	1	0	1	0	6	2	5	3	6	2	0	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr12:7548986C>T	uc001qsy.2	-	8	1781	c.1755G>A	c.(1753-1755)CTG>CTA	p.L585L	CD163L1_uc010sge.1_Silent_p.L595L	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	585	SRCR 6.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TGCCGCCCACCAGCCTCAGGC	0.453													10	14					0	0	0	0	T	7548986	T	T	7548986	2	4	200	1	0	0	0	0	0	0	0	1	2983	581	21	4		4	CD163L1	12	7548986	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08		7548986	126302909	112	36722											
GRIN2B	2904	broad.mit.edu	37	chr12	13828794	13828794	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgacattgatcagatacCtgtaaagataaaataaaagg	20	9	8	4	0	1	4	1	2	0	2	1	4	1	4	1	1	1	1	1	1	8	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr12:13828794C>T	uc001rbt.2	-	4	1190	c.1011_splice	c.e4-1	p.R337_splice		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B						response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GATCAGATACCTGTAAAGATA	0.408													28	58					0	0	0	0	T	13828794	T	T	13828794	5	4	200	1	0	0	0	0	0	0	1	0	6819	695	24	4	3484	4	GRIN2B	12	13828794	Splice_Site	SNP	C	TCGA-CV-6941-01A-11D-1912-08	6279808	13828794	120023101	113	36723											
SFRS2IP	9169	broad.mit.edu	37	chr12	46321867	46321867	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgaactgtacatacatcTgtctttacctctgattgtga	11	15	7	8	0	3	4	0	3	3	1	3	4	3	4	1	0	4	1	1	0	4	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr12:46321867T>C	uc001rox.2	-	11	1904	c.1617A>G	c.(1615-1617)ACA>ACG	p.T539T	SFRS2IP_uc001row.2_Silent_p.T224T|SFRS2IP_uc001roy.1_Silent_p.T613T	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	539					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		TACATACATCTGTCTTTACCT	0.368													18	79					0	0	0	0	C	46321867	C	C	46321867	2	2	200	1	0	0	0	0	0	0	0	1	14242	1567	55	5		5	SFRS2IP	12	46321867	Silent	SNP	T	TCGA-CV-6941-01A-11D-1912-08	32493073	46321867	87530028	114	36724											
SLC11A2	4891	broad.mit.edu	37	chr12	51384679	51384679	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataaaccactacaaagtacaTattgatggaacagatgataa	20	9	6	6	0	0	3	0	2	0	1	0	4	0	4	1	1	4	1	1	1	8	6			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr12:51384679T>A	uc001rxe.3	-	15	1571	c.1474A>T	c.(1474-1476)ATG>TTG	p.M492L	SLC11A2_uc001rxd.3_Missense_Mutation_p.M341L|SLC11A2_uc001rxc.3_Missense_Mutation_p.M492L|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_Missense_Mutation_p.M105L|SLC11A2_uc010smx.1_Missense_Mutation_p.M488L|SLC11A2_uc001rxh.1_Missense_Mutation_p.M492L|SLC11A2_uc001rxj.1_Missense_Mutation_p.M492L|SLC11A2_uc001rxi.2_Missense_Mutation_p.M492L|SLC11A2_uc001rxk.1_Missense_Mutation_p.M521L|SLC11A2_uc010smy.1_Missense_Mutation_p.M455L	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	492	Helical; (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						ACAAAGTACATATTGATGGAA	0.468													22	22					0	0	0	0	A	51384679	A	A	51384679	3	1	200	1	0	0	0	0	1	0	0	0	14446	1406	49	5	301	5	SLC11A2	12	51384679	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	5062812	51384679	82467216	115	36725											
KRT72	140807	broad.mit.edu	37	chr12	52992876	52992876	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtctctagcacctgattCtgctgctccaggaaccgcac	7	11	9	14	1	2	1	0	1	2	0	4	2	3	2	3	2	4	4	3	2	2	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr12:52992876C>T	uc001sar.2	-	2	533	c.447G>A	c.(445-447)CAG>CAA	p.Q149Q	KRT72_uc001saq.2_Silent_p.Q149Q|KRT72_uc010sns.1_Silent_p.Q149Q|KRT72_uc010snt.1_5'UTR	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	149	Coil 1A.|Rod.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		GCACCTGATTCTGCTGCTCCA	0.547													16	51					0	0	0	0	T	52992876	T	T	52992876	2	4	200	1	0	0	0	0	0	0	0	1	8524	912	32	2		2	KRT72	12	52992876	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	1608197	52992876	80859019	116	36726											
XPOT	11260	broad.mit.edu	37	chr12	64818925	64818925	+	Frame_Shift_Del	DEL	T	-	-																															tgctcacttctcaggtgatgTttcaaaagctagtgctttgc																										TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr12:64818925delT	uc001ssb.2	+	13	1841	c.1415delT	c.(1414-1416)GTTfs	p.V472fs		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	472	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		TCAGGTGATGTTTCAAAAGCT	0.383													---	---	---								-	64818925	-	-	64818925	7	5	200	1	0	1	0	1	0	0	0	0	17518	1725	60	0	1461	0	XPOT	12	64818925	Frame_Shift_Del	DEL	T	TCGA-CV-6941-01A-11D-1912-08	11826049	64818925	69032970	117	36727											
RAB3IP	117177	broad.mit.edu	37	chr12	70194071	70194071	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcctttcttagacaaaaTctaccaggaagatatctttc	12	14	6	9	0	3	2	0	0	3	2	5	3	4	3	2	1	1	0	2	1	6	5			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr12:70194071T>A	uc001svp.2	+	7	1466	c.1019T>A	c.(1018-1020)ATC>AAC	p.I340N	RAB3IP_uc001svm.2_Missense_Mutation_p.I324N|RAB3IP_uc001svn.2_Missense_Mutation_p.I324N|RAB3IP_uc001svo.2_Intron|RAB3IP_uc001svq.2_Missense_Mutation_p.I340N|RAB3IP_uc001svr.2_RNA|RAB3IP_uc001svs.2_Intron|RAB3IP_uc001svt.2_Missense_Mutation_p.I118N	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	340					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			TTAGACAAAATCTACCAGGAA	0.343													7	24					0	0	0	0	A	70194071	A	A	70194071	3	1	200	1	0	0	0	0	1	0	0	0	13003	1435	50	5	1045	5	RAB3IP	12	70194071	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	5375146	70194071	63657824	118	36728											
ANO4	121601	broad.mit.edu	37	chr12	101510520	101510520	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttctgactttgagaaccgAtctgagcctgaatctgatgg	10	13	10	8	1	3	5	0	5	3	1	3	7	3	5	2	1	2	0	2	1	2	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr12:101510520A>C	uc010svm.1	+	25	3086	c.2514A>C	c.(2512-2514)CGA>CGC	p.R838R	ANO4_uc001thw.2_Silent_p.R803R|ANO4_uc001thx.2_Silent_p.R838R|ANO4_uc001thy.2_Silent_p.R358R	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	838	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTGAGAACCGATCTGAGCCTG	0.507										HNSCC(74;0.22)			21	85					0	0	0	0	C	101510520	C	C	101510520	2	2	200	1	0	0	0	0	0	0	0	1	699	320	12	5		5	ANO4	12	101510520	Silent	SNP	A	TCGA-CV-6941-01A-11D-1912-08	31316449	101510520	32341375	119	36729											
MYBPC1	4604	broad.mit.edu	37	chr12	102069094	102069094	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggtccaccccaaattgTgaagattgaggatgtctggg	10	10	12	9	0	1	3	0	2	1	1	3	4	3	4	4	3	0	0	4	3	2	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr12:102069094T>C	uc001tii.2	+	25	2915	c.2813T>C	c.(2812-2814)GTG>GCG	p.V938A	MYBPC1_uc001tig.2_Missense_Mutation_p.V945A|MYBPC1_uc010svq.1_Missense_Mutation_p.V907A|MYBPC1_uc001tih.2_Missense_Mutation_p.V945A|MYBPC1_uc001tij.2_Missense_Mutation_p.V920A|MYBPC1_uc010svr.1_Missense_Mutation_p.V920A|MYBPC1_uc010svs.1_Missense_Mutation_p.V938A|MYBPC1_uc010svt.1_Missense_Mutation_p.V908A|MYBPC1_uc010svu.1_Missense_Mutation_p.V901A|MYBPC1_uc001tik.2_Missense_Mutation_p.V894A|MYBPC1_uc001til.2_5'UTR|MYBPC1_uc001tim.2_5'UTR	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	938	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						CCCCAAATTGTGAAGATTGAG	0.448													9	31					0	0	0	0	C	102069094	C	C	102069094	3	2	200	1	0	0	0	0	1	0	0	0	10064	1696	59	5	2994	5	MYBPC1	12	102069094	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	558574	102069094	31782801	120	36730											
CCDC64	92558	broad.mit.edu	37	chr12	120502659	120502659	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgggtgctaatcctggagagGcagggccatgacaaggacct	10	6	15	10	1	0	2	0	1	0	1	1	4	1	3	3	5	1	2	3	5	2	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr12:120502659G>T	uc001txl.1	+	4	910	c.885G>T	c.(883-885)AGG>AGT	p.R295S	CCDC64_uc001txk.2_Missense_Mutation_p.R295S|CCDC64_uc009zwv.1_RNA|CCDC64_uc010sze.1_Missense_Mutation_p.R39S	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	295	Potential.				Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCCTGGAGAGGCAGGGCCATG	0.547													56	91					1.93748e-29	6.02892e-29	1	0	T	120502659	T	T	120502659	3	4	200	1	0	0	0	0	1	0	0	0	2848	1194	42	4	899	4	CCDC64	12	120502659	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	18433565	120502659	13349236	121	36731											
TUBGCP3	10426	broad.mit.edu	37	chr13	113200121	113200121	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcaccagagaccgcatgtaCgggtctcctgtttttgtgta	7	13	11	10	2	1	1	0	0	1	1	2	2	1	1	3	1	2	5	3	1	2	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr13:113200121C>T	uc001vse.1	-	11	1414	c.1227G>A	c.(1225-1227)CCG>CCA	p.P409P	TUBGCP3_uc010tjq.1_Silent_p.P399P|TUBGCP3_uc001vsf.2_Silent_p.P409P	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	409					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					ACCGCATGTACGGGTCTCCTG	0.502													54	45					0	0	0	0	T	113200121	T	T	113200121	2	4	200	1	0	0	0	0	0	0	0	1	16835	523	19	1		1	TUBGCP3	13	113200121	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08		113200121	1969757	122	36732											
TSHR	7253	broad.mit.edu	37	chr14	81610331	81610332	+	Nonsense_Mutation	DNP	TG	AT	AT																															atggccccaatctcattctaTgctctgtcagcaattctgaa																										TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr14:81610331_81610332TG>AT	uc001xvd.1	+	10	2085_2086	c.1929_1930TG>AT	c.(1927-1932)TATGCT>TAATCT	p.643_644YA>*S		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	643_644	Helical; Name=6; (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TCTCATTCTATGCTCTGTCAGC	0.455			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						56	98					0	0	0	0	AT	81610332	AT	AT	81610331	4	1	200	1	0	0	0	0	0	1	0	0	16689	1471	51	5	2104	5	TSHR	14	81610331	Nonsense_Mutation	DNP	TG	TCGA-CV-6941-01A-11D-1912-08		81610331	25739209	123	36733											
CLMN	79789	broad.mit.edu	37	chr14	95660246	95660246	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgttcctcaactgaacatagCtaaaatgatcctacagtgaa	15	10	6	10	1	1	3	1	3	0	0	3	3	3	3	2	0	4	2	2	0	7	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr14:95660246C>G	uc001yef.2	-	12	2896	c.2780G>C	c.(2779-2781)AGC>ACC	p.S927T		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	927						integral to membrane	actin binding				0				Epithelial(152;0.193)		CTGAACATAGCTAAAATGATC	0.378													7	50					0	0	0	0	G	95660246	G	G	95660246	3	3	200	1	0	0	0	0	1	0	0	0	3557	797	28	4	236	4	CLMN	14	95660246	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	14049915	95660246	11689294	124	36734											
GABRG3	2567	broad.mit.edu	37	chr15	27572157	27572157	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggatttggaatgacgggAaaatcctttacactttgagg	11	12	11	7	2	0	2	0	2	0	0	2	5	2	5	2	4	1	0	2	4	4	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr15:27572157A>T	uc001zbg.1	+	4	638	c.472A>T	c.(472-474)AAA>TAA	p.K158*	GABRG3_uc001zbf.2_Nonsense_Mutation_p.K158*	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	158	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		GAATGACGGGAAAATCCTTTA	0.443													13	16					0	0	0	0	T	27572157	T	T	27572157	4	4	200	1	0	0	0	0	0	1	0	0	6207	247	9	5	486	5	GABRG3	15	27572157	Nonsense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08		27572157	74959235	125	36735											
HERC2	8924	broad.mit.edu	37	chr15	28357012	28357012	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cggcggctggctctcctgtaAgtgcgatgcgagcgtagtca	6	9	15	11	5	2	0	1	0	1	0	3	2	2	0	1	3	3	4	1	3	2	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr15:28357012A>C	uc001zbj.2	-	93	14508	c.14402T>G	c.(14401-14403)CTT>CGT	p.L4801R	HERC2_uc001zbi.2_Missense_Mutation_p.L490R	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4801					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTCTCCTGTAAGTGCGATGCG	0.527													23	53					0	0	0	0	C	28357012	C	C	28357012	3	2	200	1	0	0	0	0	1	0	0	0	7097	72	3	5	106	5	HERC2	15	28357012	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08	784855	28357012	74174380	126	36736											
ACSBG1	23205	broad.mit.edu	37	chr15	78472020	78472020	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctctgccatcatgggggcCgctccatagaagttcttttg	6	13	11	11	1	3	1	1	0	2	1	5	1	4	1	3	2	1	2	3	2	2	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr15:78472020C>T	uc002bdh.2	-	10	1412	c.1356G>A	c.(1354-1356)GCG>GCA	p.A452A	ACSBG1_uc010umw.1_Silent_p.A448A|ACSBG1_uc010umx.1_Silent_p.A210A	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	452					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						TCATGGGGGCCGCTCCATAGA	0.557													10	52					0	0	0	0	T	78472020	T	T	78472020	2	4	200	1	0	0	0	0	0	0	0	1	173	639	23	1		1	ACSBG1	15	78472020	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	50115008	78472020	24059372	127	36737											
KLHL25	64410	broad.mit.edu	37	chr15	86311556	86311556	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccgtgtcacctcccatgaTgaagatctggctgcccagga	8	10	10	13	1	2	3	1	2	1	1	4	4	4	4	4	2	1	1	4	2	1	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr15:86311556T>A	uc002bly.2	-	2	1689	c.1486A>T	c.(1486-1488)ATC>TTC	p.I496F		NM_022480	NP_071925	Q9H0H3	ENC2_HUMAN	BTB/POZ KELCH domain protein	496	Kelch 5.					cytoplasm				ovary(2)	2						CCTCCCATGATGAAGATCTGG	0.617													38	61					0	0	0	0	A	86311556	A	A	86311556	3	1	200	1	0	0	0	0	1	0	0	0	8419	1464	51	5	287	5	KLHL25	15	86311556	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	7839536	86311556	16219836	128	36738											
RHOT2	89941	broad.mit.edu	37	chr16	721109	721109	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcctgaacacgctcttcAtccagcgcggccggcacgag	7	8	10	16	5	3	1	1	1	2	0	5	2	5	1	3	2	2	2	3	2	1	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr16:721109A>G	uc002cip.2	+	11	842	c.775A>G	c.(775-777)ATC>GTC	p.I259V	RHOT2_uc002ciq.2_Missense_Mutation_p.I152V|RHOT2_uc010bqy.2_Missense_Mutation_p.I38V	NM_138769	NP_620124	Q8IXI1	MIRO2_HUMAN	ras homolog gene family, member T2	259	Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			pancreas(1)	1		Hepatocellular(780;0.0218)				CACGCTCTTCATCCAGCGCGG	0.657													19	45					0	0	0	0	G	721109	G	G	721109	3	3	200	1	0	0	0	0	1	0	0	0	13409	217	8	5	817	5	RHOT2	16	721109	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08		721109	89633644	129	36739											
SOX8	30812	broad.mit.edu	37	chr16	1035026	1035026	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccgtcggcctccgcgtcGcccaccgagacgggtccccc	3	4	12	22	7	0	1	0	0	0	1	4	2	2	1	8	2	0	0	8	2	0	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr16:1035026G>A	uc002ckn.2	+	3	1096	c.981G>A	c.(979-981)TCG>TCA	p.S327S		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	327					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				CCTCCGCGTCGCCCACCGAGA	0.756													5	7					0	0	0	0	A	1035026	A	A	1035026	2	1	200	1	0	0	0	0	0	0	0	1	15021	1074	38	1		1	SOX8	16	1035026	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	313917	1035026	89319727	130	36740											
ZNF205	7755	broad.mit.edu	37	chr16	3169975	3169975	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agctcggcgctagtcacccaCcagcgcacccacactggggt	8	5	11	17	3	1	0	1	0	0	0	2	0	1	0	3	3	2	3	3	3	1	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr16:3169975C>T	uc002cub.2	+	7	1449	c.1314C>T	c.(1312-1314)CAC>CAT	p.H438H	ZNF205_uc002cua.2_Silent_p.H438H	NM_001042428	NP_001035893	O95201	ZN205_HUMAN	zinc finger protein 205	438	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						TAGTCACCCACCAGCGCACCC	0.657													21	59					0	0	0	0	T	3169975	T	T	3169975	2	4	200	1	0	0	0	0	0	0	0	1	17831	506	18	4		4	ZNF205	16	3169975	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	2134949	3169975	87184778	131	36741											
APOB48R	55911	broad.mit.edu	37	chr16	28506581	28506581	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctggagggccttagaggcagCcaaaacgagggggctggaag	11	4	18	8	1	0	1	0	0	0	1	0	4	0	3	2	6	2	2	2	6	4	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr16:28506581C>G	uc002dqb.1	+	2	229	c.219C>G	c.(217-219)AGC>AGG	p.S73R	uc010vct.1_Intron|CLN3_uc002dpp.2_5'Flank|APOB48R_uc010byg.1_5'UTR	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	73					cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						TTAGAGGCAGCCAAAACGAGG	0.617													9	4					0	0	0	0	G	28506581	G	G	28506581	3	3	200	1	0	0	0	0	1	0	0	0	786	738	26	4	225	4	APOB48R	16	28506581	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	25336606	28506581	61848172	132	36742											
ZNF764	92595	broad.mit.edu	37	chr16	30567359	30567359	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcagcccaggagacccggcgGccacagggtcgggcttctcc	6	5	14	16	3	2	1	1	0	1	1	4	2	2	1	4	5	1	1	4	5	0	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr16:30567359G>A	uc002dyq.2	-	3	464	c.383C>T	c.(382-384)GCC>GTC	p.A128V	ZNF764_uc002dyr.1_Missense_Mutation_p.A127V	NM_033410	NP_219363	Q96H86	ZN764_HUMAN	zinc finger protein 764	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGACCCGGCGGCCACAGGGTC	0.632													14	83					0	0	0	0	A	30567359	A	A	30567359	3	1	200	1	0	0	0	0	1	0	0	0	18205	1203	42	4	847	4	ZNF764	16	30567359	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	2060778	30567359	59787394	133	36743											
PRR14	78994	broad.mit.edu	37	chr16	30667619	30667619	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aacagtagatcgggagcagcCccactggacctaggtgcccc	10	5	12	14	1	0	1	0	0	0	1	1	3	0	3	5	3	4	2	5	3	3	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr16:30667619C>T	uc002dyy.2	+	12	2003	c.1745C>T	c.(1744-1746)CCC>CTC	p.P582L	PRR14_uc002dyz.2_Missense_Mutation_p.P427L|PRR14_uc002dza.2_Missense_Mutation_p.P582L	NM_024031	NP_076936	Q9BWN1	PRR14_HUMAN	proline rich 14	582											0			Colorectal(24;0.103)			CGGGAGCAGCCCCACTGGACC	0.537													10	65					0	0	0	0	T	30667619	T	T	30667619	3	4	200	1	0	0	0	0	1	0	0	0	12648	623	22	4	1787	4	PRR14	16	30667619	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	100260	30667619	59687134	134	36744											
CES7	221223	broad.mit.edu	37	chr16	55907847	55907847	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggggagcagcaaaggggactCcgaggaacacgttcacaggc	12	3	16	10	2	1	0	1	0	0	0	2	4	2	3	1	6	3	3	1	6	2	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr16:55907847C>A	uc002eip.2	-	2	325	c.176G>T	c.(175-177)GGA>GTA	p.G59V	CES7_uc002eio.2_Missense_Mutation_p.G59V|CES7_uc002eiq.2_5'UTR|CES7_uc002eir.2_5'UTR	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	59						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		AAAGGGGACTCCGAGGAACAC	0.597													21	15					1.10513e-12	3.32735e-12	1	0	A	55907847	A	A	55907847	3	1	200	1	0	0	0	0	1	0	0	0	3287	855	30	2	1599	2	CES7	16	55907847	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	25240228	55907847	34446906	135	36745											
SPG7	6687	broad.mit.edu	37	chr16	89619494	89619494	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttgagcggatgtgcatggcCctgggaggacgggcctcgga	6	8	18	9	3	0	1	0	1	0	0	1	5	0	5	2	6	2	1	2	6	0	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr16:89619494C>T	uc002fnj.2	+	14	1908	c.1887C>T	c.(1885-1887)GCC>GCT	p.A629A	SPG7_uc002fnk.1_RNA|SPG7_uc002fnl.2_Silent_p.A38A	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	629	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		TGTGCATGGCCCTGGGAGGAC	0.622													4	6					0	0	0	0	T	89619494	T	T	89619494	2	4	200	1	0	0	0	0	0	0	0	1	15110	610	22	4		4	SPG7	16	89619494	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	33711647	89619494	735259	136	36746											
TP53	7157	broad.mit.edu	37	chr17	7578384	7578401	+	In_Frame_Del	DEL	GCAGCGCTCATGGTGGGG	-	-																															tgctcaccatcgctatctgaGcagcgctcatggtgggggca																								rs138525931	by1000genomes	TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:7578384_7578401delGCAGCGCTCATGGTGGGG	uc002gim.2	-	5	723_740	c.529_546delCCCCACCATGAGCGCTGC	c.(529-546)CCCCACCATGAGCGCTGCdel	p.PHHERC177del	TP53_uc002gig.1_In_Frame_Del_p.PHHERC177del|TP53_uc002gih.2_In_Frame_Del_p.PHHERC177del|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.PHHERC45del|TP53_uc010cng.1_In_Frame_Del_p.PHHERC45del|TP53_uc002gii.1_In_Frame_Del_p.PHHERC45del|TP53_uc010cnh.1_In_Frame_Del_p.PHHERC177del|TP53_uc010cni.1_In_Frame_Del_p.PHHERC177del|TP53_uc002gij.2_In_Frame_Del_p.PHHERC177del|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_In_Frame_Del_p.PHHERC84del|TP53_uc002gio.2_In_Frame_Del_p.PHHERC45del|TP53_uc010vug.1_In_Frame_Del_p.PHHERC138del	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	177_182	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(98)|p.H179Y(74)|p.H179L(31)|p.R181H(20)|p.H179Q(17)|p.P177L(17)|p.P177R(15)|p.R181P(14)|p.H179N(13)|p.E180*(13)|p.R181C(13)|p.H178fs*69(10)|p.H179D(10)|p.P177P(10)|p.H178Y(8)|p.P177_C182delPHHERC(8)|p.P177S(8)|p.C182S(8)|p.0?(7)|p.H178P(6)|p.E180K(5)|p.H178fs*3(5)|p.H178Q(5)|p.C182*(5)|p.H178D(4)|p.C176_R181delCPHHER(3)|p.H179P(3)|p.H178N(3)|p.P177H(3)|p.E180D(3)|p.R175_E180delRCPHHE(3)|p.R181L(3)|p.R174fs*24(3)|p.H179fs*68(2)|p.H179H(2)|p.R174fs*1(2)|p.H178H(2)|p.P177fs*3(2)|p.C182Y(2)|p.C182C(2)|p.C182R(2)|p.R181R(2)|p.V173fs*59(2)|p.V173fs*69(1)|p.R175_H178>X(1)|p.E180G(1)|p.E180fs*67(1)|p.E180Q(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.H178fs*6(1)|p.H178L(1)|p.R174fs*3(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.P177fs*4(1)|p.H168fs*69(1)|p.E180>DGRCPHQ(1)|p.H178del(1)|p.P177I(1)|p.E180_S183del(1)|p.P177T(1)|p.K164_P219del(1)|p.R49P(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.C176_P177delCP(1)|p.P177fs*69(1)|p.R42fs*24(1)|p.R88P(1)|p.C182fs*4(1)|p.R174_E180>K(1)|p.P177_E180delPHHE(1)|p.C182fs*65(1)|p.C176fs*65(1)|p.R181G(1)|p.C176fs*68(1)|p.R174_H178>S(1)|p.R181>XXXXXXX(1)|p.H178_H179>QY(1)|p.?(1)|p.R81fs*24(1)|p.P177_H179delPHH(1)|p.E180fs*6(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGCTATCTGAGCAGCGCTCATGGTGGGGGCAGCGCCTC	0.638		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578401	-	-	7578384	7	5	200	1	0	1	0	1	0	0	0	0	16448	963	34	0	752	0	TP53	17	7578384	In_Frame_Del	DEL	GCAGCGCTCATGGTGGGG	TCGA-CV-6941-01A-11D-1912-08		7578384	73616826	137	36747											
MYH8	4626	broad.mit.edu	37	chr17	10303904	10303904	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagggtggcctcctccaggtCcctgcgcagtttctgaaact	6	10	11	14	1	1	1	0	1	1	0	4	1	4	1	4	3	2	2	4	3	1	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:10303904C>G	uc002gmm.2	-	27	3633	c.3538G>C	c.(3538-3540)GAC>CAC	p.D1180H	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1180	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TCCTCCAGGTCCCTGCGCAGT	0.567									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				52	109					0	0	0	0	G	10303904	G	G	10303904	3	3	200	1	0	0	0	0	1	0	0	0	10094	855	30	2	2331	2	MYH8	17	10303904	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	2725520	10303904	70891306	138	36748											
MYO15A	51168	broad.mit.edu	37	chr17	18065898	18065898	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaactccctgcttctgcaGggatcgccaaggcctgcgag	7	8	12	14	2	1	1	0	1	1	0	3	3	2	2	3	2	4	2	3	2	2	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:18065898G>T	uc010vxh.1	+	57	9856	c.9518_splice	c.e57-1	p.G3173_splice	MYO15A_uc010vxi.1_Splice_Site_p.G437_splice|MYO15A_uc010vxk.1_Splice_Site|MYO15A_uc010vxl.1_Splice_Site_p.G162_splice|MYO15A_uc002gsl.2_Splice_Site_p.G180_splice|MYO15A_uc010vxm.1_Splice_Site_p.G95_splice|MYO15A_uc002gsm.1_Splice_Site_p.G95_splice|MYO15A_uc010cpv.2_Splice_Site	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV						sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGCTTCTGCAGGGATCGCCAA	0.537													16	6					3.41278e-10	1.01113e-09	1	0	T	18065898	T	T	18065898	5	4	200	1	0	0	0	0	0	0	1	0	10116	1014	35	4	9739	4	MYO15A	17	18065898	Splice_Site	SNP	G	TCGA-CV-6941-01A-11D-1912-08	7761994	18065898	63129312	139	36749											
GAS2L2	246176	broad.mit.edu	37	chr17	34077222	34077222	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctccagctgcacgagTgtgggcgccgcaacaccaaa	9	6	10	16	3	0	0	0	0	0	0	3	1	3	0	5	1	3	3	5	1	2	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:34077222T>A	uc002hjv.1	-	2	529	c.501A>T	c.(499-501)ACA>ACT	p.T167T		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	167					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCTGCACGAGTGTGGGCGCCG	0.711													88	184					0	0	0	0	A	34077222	A	A	34077222	2	1	200	1	0	0	0	0	0	0	0	1	6282	1683	59	5		5	GAS2L2	17	34077222	Silent	SNP	T	TCGA-CV-6941-01A-11D-1912-08	16011324	34077222	47117988	140	36750											
KRT31	3881	broad.mit.edu	37	chr17	39553595	39553595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccaggtagctggccaggCggtcgttcaggaactgcata	8	9	13	11	2	2	0	1	0	1	0	4	1	2	1	2	5	3	4	2	5	3	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:39553595C>T	uc002hwn.2	-	1	250	c.197G>A	c.(196-198)CGC>CAC	p.R66H	KRT31_uc010cxn.2_Missense_Mutation_p.R66H	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	66	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				GCTGGCCAGGCGGTCGTTCAG	0.612													41	86					0	0	0	0	T	39553595	T	T	39553595	3	4	200	1	0	0	0	0	1	0	0	0	8506	768	27	1	1081	1	KRT31	17	39553595	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	5476373	39553595	41641615	141	36751											
KIF18B	146909	broad.mit.edu	37	chr17	43004426	43004426	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttggcttggggcccttcatgGtgaacaggggcacaggtgcc	6	9	16	10	0	1	1	1	1	0	0	1	1	1	1	2	7	2	2	2	7	1	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:43004426G>A	uc010wji.1	-	14	2407	c.2306C>T	c.(2305-2307)ACC>ATC	p.T769I	KIF18B_uc002iht.2_Missense_Mutation_p.T778I|KIF18B_uc010wjh.1_Missense_Mutation_p.T766I	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				GCCCTTCATGGTGAACAGGGG	0.527													13	24					0	0	0	0	A	43004426	A	A	43004426	3	1	200	1	0	0	0	0	1	0	0	0	8320	1261	44	4	272	4	KIF18B	17	43004426	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	3450831	43004426	38190784	142	36752											
XYLT2	64132	broad.mit.edu	37	chr17	48432867	48432867	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccattccttcaccaggaccaAtgaggagctggtggcattcc	9	9	10	13	0	1	1	1	1	0	0	3	3	3	3	5	4	1	2	5	4	1	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:48432867A>G	uc002iqo.2	+	5	1122	c.1013A>G	c.(1012-1014)AAT>AGT	p.N338S	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	338	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					ACCAGGACCAATGAGGAGCTG	0.562													6	50					0	0	0	0	G	48432867	G	G	48432867	3	3	200	1	0	0	0	0	1	0	0	0	17532	101	4	5	1031	5	XYLT2	17	48432867	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08	5428441	48432867	32762343	143	36753											
VEZF1	7716	broad.mit.edu	37	chr17	56060238	56060238	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgagatggtacacatctcGgaaggccttcccacacatct	11	10	8	12	1	2	1	0	1	2	1	4	3	3	2	2	3	1	1	2	3	2	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:56060238G>A	uc002ivf.1	-	2	693	c.550C>T	c.(550-552)CGA>TGA	p.R184*	VEZF1_uc010dcn.1_Nonsense_Mutation_p.R28*	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	184	C2H2-type 2.				cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						TACACATCTCGGAAGGCCTTC	0.498													16	45					0	0	0	0	A	56060238	A	A	56060238	4	1	200	1	0	0	0	0	0	1	0	0	17223	1124	39	1	1035	1	VEZF1	17	56060238	Nonsense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	7627371	56060238	25134972	144	36754											
TEX14	56155	broad.mit.edu	37	chr17	56729334	56729334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	taccaagttgaacaggacagGggactggaagacgaacagcc	15	4	13	9	1	0	2	0	1	0	1	0	6	0	5	2	4	4	1	2	4	5	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:56729334G>A	uc010dcz.1	-	2	147	c.29C>T	c.(28-30)CCC>CTC	p.P10L	TEX14_uc002iwr.1_Missense_Mutation_p.P10L|TEX14_uc002iws.1_Missense_Mutation_p.P10L|TEX14_uc010dda.1_5'UTR	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	10						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AACAGGACAGGGGACTGGAAG	0.398													13	32					0	0	0	0	A	56729334	A	A	56729334	3	1	200	1	0	0	0	0	1	0	0	0	15844	1232	43	4	4574	4	TEX14	17	56729334	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	669096	56729334	24465876	145	36755											
TTYH2	94015	broad.mit.edu	37	chr17	72209745	72209745	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccatgcaggcggcgcgcgtgGactacatcgctccctggtgg	5	7	15	14	5	0	0	0	0	0	0	2	1	1	1	2	5	2	2	2	5	1	1			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:72209745G>C	uc002jkc.2	+	1	50	c.19G>C	c.(19-21)GAC>CAC	p.D7H	TTYH2_uc010wqw.1_5'Flank|MGC16275_uc002jkb.2_5'Flank	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	7	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						GGCGCGCGTGGACTACATCGC	0.627													5	14					0	0	0	0	C	72209745	C	C	72209745	3	2	200	1	0	0	0	0	1	0	0	0	16808	1174	41	2	21	2	TTYH2	17	72209745	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	15480411	72209745	8985465	146	36756											
CBX2	84733	broad.mit.edu	37	chr17	77758172	77758172	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaggaagcaaaatcccgaaGgcccccagcggtggggctgt	10	4	14	13	2	0	0	0	0	0	0	1	2	1	1	4	5	2	2	4	5	4	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr17:77758172G>A	uc002jxc.2	+	5	972	c.930G>A	c.(928-930)AAG>AAA	p.K310K		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	310					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			AAATCCCGAAGGCCCCCAGCG	0.682													6	33					0	0	0	0	A	77758172	A	A	77758172	2	1	200	1	0	0	0	0	0	0	0	1	2730	991	35	4		4	CBX2	17	77758172	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	5548427	77758172	3437038	147	36757											
MC5R	4161	broad.mit.edu	37	chr18	13826243	13826243	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	catgacggcgaggcgctcagGggccatcatcgccggcatct	7	6	14	14	5	3	1	2	1	1	0	4	2	3	1	2	5	0	2	2	5	0	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr18:13826243G>A	uc010xaf.1	+	1	479	c.479G>A	c.(478-480)GGG>GAG	p.G160E		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	160	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						AGGCGCTCAGGGGCCATCATC	0.577													128	226					0	0	0	0	A	13826243	A	A	13826243	3	1	200	1	0	0	0	0	1	0	0	0	9420	1232	43	4	481	4	MC5R	18	13826243	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08		13826243	64251005	148	36758											
OSBPL1A	114876	broad.mit.edu	37	chr18	21759702	21759702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcaagtgaaaggcctcacCgcactaattcataagtctct	13	10	7	11	1	3	1	2	1	1	0	4	1	3	1	2	1	1	2	2	1	4	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr18:21759702C>T	uc002kve.2	-	20	2084	c.1910G>A	c.(1909-1911)CGA>CAA	p.R637Q	OSBPL1A_uc002kvd.2_Missense_Mutation_p.R124Q|OSBPL1A_uc010xbc.1_Missense_Mutation_p.R255Q	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	637					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					AAGGCCTCACCGCACTAATTC	0.448													5	24					0	0	0	0	T	21759702	T	T	21759702	3	4	200	1	0	0	0	0	1	0	0	0	11331	666	23	1	978	1	OSBPL1A	18	21759702	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	7933459	21759702	56317546	149	36759											
MOCOS	55034	broad.mit.edu	37	chr18	33795646	33795646	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gactggcctgtccctcaggcCcatgctgacaccggggagac	7	6	13	15	1	1	2	1	1	0	1	2	4	2	2	4	4	1	1	4	4	0	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr18:33795646C>T	uc002kzq.3	+	8	1526	c.1503C>T	c.(1501-1503)GCC>GCT	p.A501A		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	501					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	TCCCTCAGGCCCATGCTGACA	0.567													6	15					0	0	0	0	T	33795646	T	T	33795646	2	4	200	1	0	0	0	0	0	0	0	1	9742	610	22	4		4	MOCOS	18	33795646	Silent	SNP	C	TCGA-CV-6941-01A-11D-1912-08	12035944	33795646	44281602	150	36760											
MIER2	54531	broad.mit.edu	37	chr19	312210	312210	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcggatcaccttcacgttGaaccgcagccttcgcagggc	7	8	10	16	4	2	1	2	1	0	0	4	2	2	2	4	2	2	3	4	2	1	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr19:312210G>A	uc002lok.1	-	9	879	c.870C>T	c.(868-870)TTC>TTT	p.F290F		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	290	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTTCACGTTGAACCGCAGCC	0.637													12	34					0	0	0	0	A	312210	A	A	312210	2	1	200	1	0	0	0	0	0	0	0	1	9634	1281	45	2		2	MIER2	19	312210	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08		312210	58816773	151	36761											
ELAVL1	1994	broad.mit.edu	37	chr19	8032636	8032636	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcctcttctgcctccgaccGtttgtcaaaccggataaacg	8	11	8	14	4	3	0	1	0	2	0	4	2	4	1	5	1	4	1	5	1	3	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr19:8032636G>A	uc002mjb.2	-	5	636	c.469C>T	c.(469-471)CGG>TGG	p.R157W		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	157	RRM 2.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						GCCTCCGACCGTTTGTCAAAC	0.468													23	32					0	0	0	0	A	8032636	A	A	8032636	3	1	200	1	0	0	0	0	1	0	0	0	5073	1144	40	1	519	1	ELAVL1	19	8032636	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	7720426	8032636	51096347	152	36762											
CALR	811	broad.mit.edu	37	chr19	13054358	13054358	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcatcctccaggtcaagtCtggcaccatctttgacaact	10	12	6	13	0	4	1	2	1	2	0	6	1	6	1	3	2	1	1	3	2	2	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr19:13054358C>T	uc002mvu.2	+	8	1048	c.968C>T	c.(967-969)TCT>TTT	p.S323F	CALR_uc002mvv.2_5'Flank|RAD23A_uc002mvw.1_5'Flank|RAD23A_uc002mvx.1_5'Flank|RAD23A_uc002mvz.1_5'Flank|RAD23A_uc002mwa.1_5'Flank|RAD23A_uc002mvy.1_5'Flank|RAD23A_uc010xmw.1_5'Flank	NM_004343	NP_004334	P27797	CALR_HUMAN	calreticulin precursor	323	C-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGGTCAAGTCTGGCACCATC	0.512													10	25					0	0	0	0	T	13054358	T	T	13054358	3	4	200	1	0	0	0	0	1	0	0	0	2604	913	32	2	998	2	CALR	19	13054358	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	5021722	13054358	46074625	153	36763											
PIK3R2	5296	broad.mit.edu	37	chr19	18278008	18278008	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagagccgcacgaagctggAgcagcagctgcgggcccagg	9	3	17	12	3	0	1	0	1	0	1	0	4	0	2	2	3	6	5	2	3	1	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr19:18278008A>T	uc002nia.1	+	13	2140	c.1628A>T	c.(1627-1629)GAG>GTG	p.E543V	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	543					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						ACGAAGCTGGAGCAGCAGCTG	0.637													22	29					0	0	0	0	T	18278008	T	T	18278008	3	4	200	1	0	0	0	0	1	0	0	0	11974	304	11	5	1674	5	PIK3R2	19	18278008	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08	5223650	18278008	40850975	154	36764											
LGI4	163175	broad.mit.edu	37	chr19	35617874	35617874	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctccccttggtaggagaaggGctctacgctcagtgccgact	7	9	12	13	2	2	1	1	0	1	1	3	3	3	1	3	3	2	3	3	3	3	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr19:35617874G>A	uc002nxx.2	-	7	1270	c.676C>T	c.(676-678)CCC>TCC	p.P226S	LGI4_uc002nxy.1_Missense_Mutation_p.P54S|LGI4_uc002nxz.1_Missense_Mutation_p.P54S	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	226	EAR 1.					extracellular region				pancreas(1)	1	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			TAGGAGAAGGGCTCTACGCTC	0.647													16	16					0	0	0	0	A	35617874	A	A	35617874	3	1	200	1	0	0	0	0	1	0	0	0	8795	1203	42	4	949	4	LGI4	19	35617874	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	17339866	35617874	23511109	155	36765											
ZNF573	126231	broad.mit.edu	37	chr19	38230129	38230129	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccatacaagctaaaggccTttccgcattccttgcattca	11	11	6	13	1	1	0	1	0	0	0	3	0	3	0	4	1	4	3	4	1	4	6			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr19:38230129T>G	uc002ohe.2	-	4	1284	c.1262A>C	c.(1261-1263)AAG>ACG	p.K421T	ZNF573_uc010efs.2_Missense_Mutation_p.K334T|ZNF573_uc002ohd.2_Missense_Mutation_p.K419T|ZNF573_uc002ohf.2_Missense_Mutation_p.K363T|ZNF573_uc002ohg.2_Missense_Mutation_p.K333T	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	401	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			GCTAAAGGCCTTTCCGCATTC	0.378													66	198					0	0	0	0	G	38230129	G	G	38230129	3	3	200	1	0	0	0	0	1	0	0	0	18072	1609	56	5	739	5	ZNF573	19	38230129	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	2612255	38230129	20898854	156	36766											
ZNF814	730051	broad.mit.edu	37	chr19	58384572	58384572	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgatgtgcaatgagttggTacttgtttctaaaaaatttc	11	17	8	5	0	2	2	0	2	2	0	3	2	2	2	0	1	2	4	0	1	5	6			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr19:58384572T>C	uc002qqo.2	-	3	2458	c.2186A>G	c.(2185-2187)TAC>TGC	p.Y729C	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	729	C2H2-type 19.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						AATGAGTTGGTACTTGTTTCT	0.378													4	8					0	0	0	0	C	58384572	C	C	58384572	3	2	200	1	0	0	0	0	1	0	0	0	18243	1638	57	5	385	5	ZNF814	19	58384572	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	20154443	58384572	744411	157	36767											
SIRPB1	10326	broad.mit.edu	37	chr20	1551507	1551507	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgagatctccagggcatagCttttgctgactgcttgctgc	6	13	11	11	0	1	2	0	2	1	1	2	3	1	2	1	1	5	5	1	1	1	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr20:1551507C>T	uc010gai.2	-	4	1127	c.1028G>A	c.(1027-1029)AGC>AAC	p.S343N	SIRPB1_uc002wfk.3_Intron	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	343	Ig-like C1-type 2.|Extracellular (Potential).				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						CAGGGCATAGCTTTTGCTGAC	0.512													31	125					0	0	0	0	T	1551507	T	T	1551507	3	4	200	1	0	0	0	0	1	0	0	0	14398	797	28	4	176	4	SIRPB1	20	1551507	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08		1551507	61474013	158	36768											
TGM3	7053	broad.mit.edu	37	chr20	2315841	2315841	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacatgatccggatcacagcGgtgtgcaaggtcccagatga	12	7	12	10	2	1	3	1	2	0	1	3	4	3	4	2	3	3	1	2	3	2	0			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr20:2315841G>A	uc002wfx.3	+	11	1819	c.1722G>A	c.(1720-1722)GCG>GCA	p.A574A		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	574					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	GGATCACAGCGGTGTGCAAGG	0.552													34	42					0	0	0	0	A	2315841	A	A	2315841	2	1	200	1	0	0	0	0	0	0	0	1	15897	1103	39	1		1	TGM3	20	2315841	Silent	SNP	G	TCGA-CV-6941-01A-11D-1912-08	764334	2315841	60709679	159	36769											
PLCB1	23236	broad.mit.edu	37	chr20	8709798	8709798	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgcaggttgtcagatggTggcacttaatttccagacaa	12	11	11	7	0	1	2	1	0	0	2	2	3	2	2	1	3	1	3	1	3	3	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr20:8709798T>C	uc002wnb.2	+	18	1868	c.1865T>C	c.(1864-1866)GTG>GCG	p.V622A	PLCB1_uc010zrb.1_Missense_Mutation_p.V521A|PLCB1_uc002wna.2_Missense_Mutation_p.V622A|PLCB1_uc002wnc.1_Missense_Mutation_p.V521A|PLCB1_uc002wnd.1_Missense_Mutation_p.V199A	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	622	PI-PLC Y-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TGTCAGATGGTGGCACTTAAT	0.413													11	48					0	0	0	0	C	8709798	C	C	8709798	3	2	200	1	0	0	0	0	1	0	0	0	12082	1696	59	5	1935	5	PLCB1	20	8709798	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	6393957	8709798	54315722	160	36770											
U2AF1	7307	broad.mit.edu	37	chr21	44521539	44521539	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagatgttttgaatcaagaTggtctgcggggaaaaaaaaa	17	10	11	3	1	2	3	1	1	1	2	2	4	2	4	0	3	1	1	0	3	7	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr21:44521539T>C	uc002zda.1	-	3	220	c.136A>G	c.(136-138)ATC>GTC	p.I46V	U2AF1_uc002zcy.1_Intron|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Intron|U2AF1_uc010gpi.1_Intron|U2AF1_uc002zdc.1_Missense_Mutation_p.I46V	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	46					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						TGAATCAAGATGGTCTGCGGG	0.388													134	107					0	0	0	0	C	44521539	C	C	44521539	3	2	200	1	0	0	0	0	1	0	0	0	16889	1464	51	5	681	5	U2AF1	21	44521539	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08		44521539	3608356	161	36771											
IL2RB	3560	broad.mit.edu	37	chr22	37538536	37538536	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcacggggagcagctcacAggtttggttccaccgccttt	7	10	11	13	2	2	0	2	0	0	0	3	1	3	1	3	4	2	4	3	4	0	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr22:37538536A>T	uc003aqv.1	-	4	351	c.220T>A	c.(220-222)TGT>AGT	p.C74S		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	74	Extracellular (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	AGCAGCTCACAGGTTTGGTTC	0.582													13	71					0	0	0	0	T	37538536	T	T	37538536	3	4	200	1	0	0	0	0	1	0	0	0	7726	188	7	5	1463	5	IL2RB	22	37538536	Missense_Mutation	SNP	A	TCGA-CV-6941-01A-11D-1912-08		37538536	13766030	162	36772											
TAB1	10454	broad.mit.edu	37	chr22	39832515	39832515	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacccttccaggcctgcaaGcgatttgacagccatccctc	9	8	8	16	1	0	2	0	1	0	1	3	3	2	2	5	1	3	1	5	1	1	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr22:39832515G>A	uc003axu.1	+	11	1377	c.1328G>A	c.(1327-1329)AGC>AAC	p.S443N		NM_153497	NP_705717	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	Error:Variant_position_missing_in_Q15750_after_alignment					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						AGGCCTGCAAGCGATTTGACA	0.438													9	104					0	0	0	0	A	39832515	A	A	39832515	3	1	200	1	0	0	0	0	1	0	0	0	15561	971	34	4	1582	4	TAB1	22	39832515	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	2293979	39832515	11472051	163	36773											
ATF4	468	broad.mit.edu	37	chr22	39917879	39917879	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgacctggaaaccatgccaGatgaccttctgaccacgttg	11	9	9	12	1	1	4	0	3	1	1	1	5	1	5	5	1	2	1	5	1	1	2			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chr22:39917879G>A	uc003axz.2	+	3	608	c.328G>A	c.(328-330)GAT>AAT	p.D110N	ATF4_uc011aol.1_Missense_Mutation_p.D22N|ATF4_uc003aya.2_Missense_Mutation_p.D110N	NM_182810	NP_877962	P18848	ATF4_HUMAN	activating transcription factor 4	110					cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Melanoma(58;0.04)					AACCATGCCAGATGACCTTCT	0.517													47	211					0	0	0	0	A	39917879	A	A	39917879	3	1	200	1	0	0	0	0	1	0	0	0	1084	942	33	2	334	2	ATF4	22	39917879	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	85364	39917879	11386687	164	36774											
KLHL15	80311	broad.mit.edu	37	chrX	24006507	24006507	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttctatggtcccttctttgCtggggtcaaacacgcacact	7	13	9	12	1	3	0	1	0	2	0	4	0	4	0	1	3	2	3	1	3	2	4			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chrX:24006507C>T	uc004dba.3	-	4	1602	c.1346G>A	c.(1345-1347)AGC>AAC	p.S449N		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	449	Kelch 3.									ovary(1)|breast(1)	2						CCCTTCTTTGCTGGGGTCAAA	0.458													44	30					0	0	0	0	T	24006507	T	T	24006507	3	4	200	1	0	0	0	0	1	0	0	0	8410	797	28	4	472	4	KLHL15	23	24006507	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08		24006507	131264053	165	36775											
ABCB7	22	broad.mit.edu	37	chrX	74334622	74334622	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagaactgtcctgaattgccTtttcccaatctctgccatgt	9	14	6	12	0	1	2	0	1	1	1	4	2	3	2	4	0	3	0	4	0	4	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chrX:74334622T>A	uc004eca.2	-	2	238	c.213A>T	c.(211-213)AAA>AAT	p.K71N	ABCB7_uc004ebz.2_Missense_Mutation_p.K72N|ABCB7_uc011mqn.1_Intron|ABCB7_uc010nls.2_Missense_Mutation_p.K72N|ABCB7_uc010nlt.2_Missense_Mutation_p.K71N	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	71					cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						CTGAATTGCCTTTTCCCAATC	0.388													16	8					0	0	0	0	A	74334622	A	A	74334622	3	1	200	1	0	0	0	0	1	0	0	0	46	1606	56	5	2105	5	ABCB7	23	74334622	Missense_Mutation	SNP	T	TCGA-CV-6941-01A-11D-1912-08	50328115	74334622	80935938	166	36776											
DRP2	1821	broad.mit.edu	37	chrX	100497390	100497390	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcccaccaacttgccatttCtgatgtgcacttgtcaatgg	8	12	9	12	0	2	1	1	1	1	0	2	1	2	1	3	2	3	1	3	2	2	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chrX:100497390C>G	uc004egz.2	+	8	1274	c.905C>G	c.(904-906)TCT>TGT	p.S302C	DRP2_uc011mrh.1_Missense_Mutation_p.S224C	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	302	Spectrin 2.				central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						CTTGCCATTTCTGATGTGCAC	0.498													93	43					0	0	0	0	G	100497390	G	G	100497390	3	3	200	1	0	0	0	0	1	0	0	0	4786	913	32	2	927	2	DRP2	23	100497390	Missense_Mutation	SNP	C	TCGA-CV-6941-01A-11D-1912-08	26162768	100497390	54773170	167	36777											
AFF2	2334	broad.mit.edu	37	chrX	147733537	147733537	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagtcactatgaacaagaccGtagtgcacttaaaaaaaggg	17	7	9	8	1	1	2	1	1	0	1	1	2	1	2	1	1	2	2	1	1	8	3			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chrX:147733537G>T	uc004fcp.2	+	2	544	c.65G>T	c.(64-66)CGT>CTT	p.R22L	AFF2_uc004fco.2_Missense_Mutation_p.R22L|AFF2_uc004fcq.2_Missense_Mutation_p.R22L|AFF2_uc004fcr.2_Missense_Mutation_p.R22L|AFF2_uc011mxb.1_Missense_Mutation_p.R22L|AFF2_uc004fcs.2_Missense_Mutation_p.R22L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	22					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GAACAAGACCGTAGTGCACTT	0.363													68	31					3.61678e-42	1.13816e-41	1	0	T	147733537	T	T	147733537	3	4	200	1	0	0	0	0	1	0	0	0	357	1145	40	3	71	3	AFF2	23	147733537	Missense_Mutation	SNP	G	TCGA-CV-6941-01A-11D-1912-08	47236147	147733537	7537023	168	36778											
MAGEA12	4111	broad.mit.edu	37	chrX	151896244	151896244	+	RNA	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctggatagtgttggcccActccattcctcaggtttttt	5	16	10	10	0	1	0	1	0	0	0	3	1	3	1	3	4	0	3	3	4	1	6			TCGA-CV-6941-01A-11D-1912-08	TCGA-CV-6941-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	87071681-0058-4081-91f3-f689a150fc94	68f50c4b-eb4e-4e10-9524-d81b15fd4960	g.chrX:151896244A>C	uc004fgb.2	-	4		c.523T>G						P43365	MAGAC_HUMAN	Homo sapiens melanoma antigen family A, 12, mRNA (cDNA clone MGC:4914 IMAGE:3450217), complete cds.											skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GTGTTGGCCCACTCCATTCCT	0.522													8	54					0	0	0	0	C	151896244	C	C	151896244	1	2	200	0	1	0	0	0	0	0	0	0	9217	174	6	5		5	MAGEA12	23	151896244	RNA	SNP	A	TCGA-CV-6941-01A-11D-1912-08	4162707	151896244	3374316	169	36779											
ATAD3A	55210	broad.mit.edu	37	chr1	1463191	1463192	+	Frame_Shift_Ins	INS	-	G	G																															gaggaacgggagcgcctggtINSgagaatgtattttgacaagt																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:1463191_1463192insG	uc001afz.1	+	14	1692_1693	c.1598_1599insG	c.(1597-1599)GTGfs	p.V533fs	ATAD3A_uc001aga.1_Frame_Shift_Ins_p.V485fs|ATAD3A_uc001agb.1_Frame_Shift_Ins_p.V406fs	NM_018188	NP_060658	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	533							ATP binding|nucleoside-triphosphatase activity|protein binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		GAGCGCCTGGTGAGAATGTATT	0.589													---	---	---								G	1463192	G	G	1463191	7	5	201	1	0	1	1	0	0	0	0	0	1075	1696	59	0	1652	0	ATAD3A	1	1463191	Frame_Shift_Ins	INS	-	TCGA-CV-6942-01A-21D-2012-08		1463191	247787430	1	36780											
VPS13D	55187	broad.mit.edu	37	chr1	12336511	12336511	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtggagtcgcagctcctcCtggcggaatttaaagtgaac	9	10	13	9	2	0	1	0	1	0	0	3	3	2	3	2	4	2	2	2	4	4	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:12336511C>T	uc001atv.2	+	19	3007	c.2866C>T	c.(2866-2868)CTG>TTG	p.L956L	VPS13D_uc001atw.2_Silent_p.L956L|VPS13D_uc001atx.2_Silent_p.L144L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	956					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GCAGCTCCTCCTGGCGGAATT	0.498											OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	57					0	0	0	0	T	12336511	T	T	12336511	2	4	201	1	0	0	0	0	0	0	0	1	17260	680	24	4		4	VPS13D	1	12336511	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	10873320	12336511	236914110	2	36781											
SPEN	23013	broad.mit.edu	37	chr1	16262721	16262721	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cactcagtttcccgccgcttCctctgttggcctgccttccc	2	13	7	19	2	2	0	1	0	1	0	5	0	5	0	6	1	1	3	6	1	0	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:16262721C>T	uc001axk.1	+	11	10190	c.9986C>T	c.(9985-9987)TCC>TTC	p.S3329F	SPEN_uc010obp.1_Missense_Mutation_p.S3288F	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3329	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCCGCCGCTTCCTCTGTTGGC	0.632													7	57					0	0	0	0	T	16262721	T	T	16262721	3	4	201	1	0	0	0	0	1	0	0	0	15104	855	30	2	10028	2	SPEN	1	16262721	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	3926210	16262721	232987900	3	36782											
MACF1	23499	broad.mit.edu	37	chr1	39826464	39826464	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcatggcctgatttttcaGattccatactcagccacttc	8	16	5	12	0	3	2	3	1	0	1	5	2	4	2	3	1	2	0	3	1	1	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:39826464G>C	uc010oiu.1	+	12	7696	c.7565_splice	c.e12-1	p.D2522_splice	MACF1_uc010ois.1_Splice_Site_p.D2020_splice|MACF1_uc001cda.1_Splice_Site_p.D1928_splice|MACF1_uc001cdc.1_Splice_Site_p.D1107_splice|MACF1_uc001cdb.1_Splice_Site_p.D1107_splice	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker						cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGATTTTTCAGATTCCATACT	0.348													8	36					0	0	0	0	C	39826464	C	C	39826464	5	2	201	1	0	0	0	0	0	0	1	0	9195	956	33	2	12379	2	MACF1	1	39826464	Splice_Site	SNP	G	TCGA-CV-6942-01A-21D-2012-08	23563743	39826464	209424157	4	36783											
FOXJ3	22887	broad.mit.edu	37	chr1	42744162	42744162	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgtatggaggtttcccatCtttgtgctgttggacttctt	5	18	10	8	0	2	0	0	0	2	0	3	2	3	2	1	3	1	4	1	3	1	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:42744162C>G	uc001che.2	-	5	538	c.226G>C	c.(226-228)GAT>CAT	p.D76H	FOXJ3_uc001chf.2_Missense_Mutation_p.D76H|FOXJ3_uc001chg.2_Missense_Mutation_p.D76H|FOXJ3_uc001chh.1_Missense_Mutation_p.D76H	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	76					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGTTTCCCATCTTTGTGCTGT	0.388													15	78					0	0	0	0	G	42744162	G	G	42744162	3	3	201	1	0	0	0	0	1	0	0	0	6047	913	32	2	1686	2	FOXJ3	1	42744162	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	2917698	42744162	206506459	5	36784											
DMAP1	55929	broad.mit.edu	37	chr1	44685131	44685131	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttcaagtctgcaggtgtCacgctgcggagccaacgggt	8	8	14	11	3	3	0	2	0	1	0	3	2	3	1	1	3	4	2	1	3	2	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:44685131C>G	uc001clq.1	+	8	1040	c.960C>G	c.(958-960)GTC>GTG	p.V320V	DMAP1_uc001clr.1_Silent_p.V320V|DMAP1_uc001cls.1_Silent_p.V320V|DMAP1_uc010oku.1_Silent_p.V310V	NM_001034024	NP_001029196	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	320					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					CTGCAGGTGTCACGCTGCGGA	0.582													9	29					0	0	0	0	G	44685131	G	G	44685131	2	3	201	1	0	0	0	0	0	0	0	1	4598	813	29	2		2	DMAP1	1	44685131	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1940969	44685131	204565490	6	36785											
CYP4B1	1580	broad.mit.edu	37	chr1	47264771	47264771	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accatggtgcccagcttcctCtccctgagcttctcctcctt	4	13	6	18	0	2	1	0	1	2	0	6	1	4	1	6	1	3	2	6	1	0	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:47264771C>T	uc001cqm.3	+	1	102	c.18C>T	c.(16-18)CTC>CTT	p.L6L	CYP4B1_uc009vyl.1_5'UTR|CYP4B1_uc001cqn.3_Silent_p.L6L|CYP4B1_uc009vym.2_Silent_p.L6L|CYP4B1_uc010omk.1_5'UTR	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	6					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CCAGCTTCCTCTCCCTGAGCT	0.572													4	22					0	0	0	0	T	47264771	T	T	47264771	2	4	201	1	0	0	0	0	0	0	0	1	4202	900	32	2		2	CYP4B1	1	47264771	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	2579640	47264771	201985850	7	36786											
ZFYVE9	9372	broad.mit.edu	37	chr1	52729530	52729530	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgtgtgtaatctgccattCagtgctaatgaatggtaagt	11	14	11	5	0	2	1	1	1	1	0	2	1	2	1	1	1	2	3	1	1	4	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:52729530C>G	uc001cto.2	+	5	2436	c.2264C>G	c.(2263-2265)TCA>TGA	p.S755*	ZFYVE9_uc001ctn.2_Nonsense_Mutation_p.S755*|ZFYVE9_uc001ctp.2_Nonsense_Mutation_p.S755*	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	755	FYVE-type.				endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						ATCTGCCATTCAGTGCTAATG	0.418													5	23					0	0	0	0	G	52729530	G	G	52729530	4	3	201	1	0	0	0	0	0	1	0	0	17738	838	29	2	2274	2	ZFYVE9	1	52729530	Nonsense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	5464759	52729530	196521091	8	36787											
USP1	7398	broad.mit.edu	37	chr1	62905655	62905655	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actaagagagctttggatttCacagattctcaagaaaatga	16	11	8	6	0	2	4	2	1	1	3	3	6	2	5	0	1	1	1	0	1	4	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:62905655C>G	uc001daj.1	+	2	445	c.117C>G	c.(115-117)TTC>TTG	p.F39L	USP1_uc001dak.1_Missense_Mutation_p.F39L|USP1_uc001dal.1_Missense_Mutation_p.F39L	NM_001017415	NP_001017415	O94782	UBP1_HUMAN	ubiquitin specific protease 1	39					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		CTTTGGATTTCACAGATTCTC	0.318													15	74					0	0	0	0	G	62905655	G	G	62905655	3	3	201	1	0	0	0	0	1	0	0	0	17108	825	29	2	119	2	USP1	1	62905655	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	10176125	62905655	186344966	9	36788											
USP33	23032	broad.mit.edu	37	chr1	78207408	78207408	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	taggaattttttcctgtttcCcaagactttcaaaatgaggt	11	16	7	7	0	1	2	1	1	0	1	3	3	3	3	2	2	0	1	2	2	5	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:78207408C>T	uc001dht.2	-	3	415	c.68G>A	c.(67-69)GGG>GAG	p.G23E	USP33_uc001dhu.2_5'UTR|USP33_uc001dhv.2_5'Flank|USP33_uc001dhw.2_Missense_Mutation_p.G23E	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	23					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						TTCCTGTTTCCCAAGACTTTC	0.289													3	24					0	0	0	0	T	78207408	T	T	78207408	3	4	201	1	0	0	0	0	1	0	0	0	17132	623	22	4	2864	4	USP33	1	78207408	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	15301753	78207408	171043213	10	36789											
HFM1	164045	broad.mit.edu	37	chr1	91727882	91727882	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaatttgggtttttttcaGagaaagtaaagcattgcttc	13	15	9	4	0	1	2	1	0	0	2	2	3	1	2	0	1	2	4	0	1	5	7			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:91727882G>C	uc001doa.3	-	38	4254	c.4154C>G	c.(4153-4155)TCT>TGT	p.S1385C	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.S1064C|HFM1_uc001dob.3_Missense_Mutation_p.S573C	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1385							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GTTTTTTTCAGAGAAAGTAAA	0.279													21	84					0	0	0	0	C	91727882	C	C	91727882	3	2	201	1	0	0	0	0	1	0	0	0	7122	942	33	2	161	2	HFM1	1	91727882	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	13520474	91727882	157522739	11	36790											
ABCA4	24	broad.mit.edu	37	chr1	94526123	94526123	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgtcaggaggaagatgctCatcgacatgatggagaagct	13	8	13	7	2	2	3	2	1	0	2	4	7	2	5	0	3	2	2	0	3	2	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:94526123C>T	uc001dqh.2	-	14	2234	c.2130G>A	c.(2128-2130)ATG>ATA	p.M710I	ABCA4_uc010otn.1_Missense_Mutation_p.M710I	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	710	Helical; (Potential).				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GGAAGATGCTCATCGACATGA	0.463													20	75					0	0	0	0	T	94526123	T	T	94526123	3	4	201	1	0	0	0	0	1	0	0	0	34	826	29	2	4839	2	ABCA4	1	94526123	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	2798241	94526123	154724498	12	36791											
ARHGAP29	9411	broad.mit.edu	37	chr1	94652141	94652141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atggtgttcgtggaagttttCgatgaaagtctcctagaaga	11	13	12	5	2	1	3	0	1	1	2	4	5	1	4	1	2	0	2	1	2	4	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:94652141C>T	uc001dqj.3	-	16	2063	c.1694G>A	c.(1693-1695)CGA>CAA	p.R565Q	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Missense_Mutation_p.R131Q	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	565					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TGGAAGTTTTCGATGAAAGTC	0.388													36	97					0	0	0	0	T	94652141	T	T	94652141	3	4	201	1	0	0	0	0	1	0	0	0	878	884	31	1	2123	1	ARHGAP29	1	94652141	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	126018	94652141	154598480	13	36792											
RWDD3	25950	broad.mit.edu	37	chr1	95710026	95710026	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaatctcaggcatatcctCagccaaccagaaactggcag	14	6	8	13	0	2	2	2	0	1	2	4	2	3	2	3	2	3	2	3	2	4	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:95710026C>A	uc009wdu.2	+	2	421	c.345C>A	c.(343-345)CTC>CTA	p.L115L	RWDD3_uc001drd.3_3'UTR|RWDD3_uc010oty.1_Silent_p.L100L|RWDD3_uc009wdt.2_Silent_p.L115L|RWDD3_uc001drf.3_Silent_p.L115L|RWDD3_uc001drh.3_Silent_p.L100L|RWDD3_uc009wdv.2_Intron|RWDD3_uc001drg.3_RNA|RWDD3_uc001dri.3_Silent_p.L115L	NM_015485	NP_056300	Q9Y3V2	RWDD3_HUMAN	RWD domain containing 3 isoform a	115						cytoplasm|nucleus	protein binding			ovary(1)	1		all_epithelial(167;5.99e-05)|all_lung(203;0.00168)|Lung NSC(277;0.00769)		all cancers(265;0.112)|Epithelial(280;0.229)		GGCATATCCTCAGCCAACCAG	0.443													13	46					6.72482e-11	1.07247e-10	1	0	A	95710026	A	A	95710026	2	1	201	1	0	0	0	0	0	0	0	1	13822	813	29	2		2	RWDD3	1	95710026	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1057885	95710026	153540595	14	36793											
DPYD	1806	broad.mit.edu	37	chr1	97564048	97564048	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggcataatttttaccttGatggtaggaataggcctttt	9	17	10	5	0	0	1	0	1	0	0	0	2	0	2	2	4	1	3	2	4	5	10			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:97564048G>T	uc001drv.2	-	21	2900	c.2763C>A	c.(2761-2763)ATC>ATA	p.I921I		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	921					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TTTTTACCTTGATGGTAGGAA	0.289													22	68					5.35047e-06	7.99774e-06	1	0	T	97564048	T	T	97564048	2	4	201	1	0	0	0	0	0	0	0	1	4767	1280	45	2		2	DPYD	1	97564048	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1854022	97564048	151686573	15	36794											
DPYD	1806	broad.mit.edu	37	chr1	98039322	98039322	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcccagcactgtacctttagGatcactcagaactgaaccaa	13	9	6	13	0	2	2	2	1	0	1	3	3	3	3	3	1	4	2	3	1	5	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:98039322G>A	uc001drv.2	-	11	1470	c.1333C>T	c.(1333-1335)CCT>TCT	p.P445S		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	445					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GTACCTTTAGGATCACTCAGA	0.398													24	77					0	0	0	0	A	98039322	A	A	98039322	3	1	201	1	0	0	0	0	1	0	0	0	4767	1174	41	2	1796	2	DPYD	1	98039322	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	475274	98039322	151211299	16	36795											
ANKRD35	148741	broad.mit.edu	37	chr1	145560245	145560245	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctacagcaggccctgagccGgcggcggcggggcggtaaag	7	3	18	13	5	0	1	0	1	0	0	0	1	0	1	3	7	3	2	3	7	3	2	rs146006151	byFrequency	TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:145560245G>A	uc001eob.1	+	8	839	c.731G>A	c.(730-732)CGG>CAG	p.R244Q	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.R87Q	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	244	ANK 6.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCCCTGAGCCGGCGGCGGCGG	0.552													17	62					0	0	0	0	A	145560245	A	A	145560245	3	1	201	1	0	0	0	0	1	0	0	0	664	1116	39	1	761	1	ANKRD35	1	145560245	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	47520923	145560245	103690376	17	36796											
HIST2H3D	653604	broad.mit.edu	37	chr1	149785051	149785051	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaagggcagcttgcggatCagcagctccgtagacttctg	8	9	14	10	2	2	1	1	0	1	1	3	3	3	3	1	3	4	5	1	3	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:149785051C>G	uc010pbl.1	-	1	186	c.186G>C	c.(184-186)CTG>CTC	p.L62L	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	62					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						GCTTGCGGATCAGCAGCTCCG	0.692													12	29					0	0	0	0	G	149785051	G	G	149785051	2	3	201	1	0	0	0	0	0	0	0	1	7220	813	29	2		2	HIST2H3D	1	149785051	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	4224806	149785051	99465570	18	36797											
INSRR	3645	broad.mit.edu	37	chr1	156821804	156821804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctcagctgtgacacagcGccaggactcatactggtagg	9	7	13	12	2	2	1	2	1	0	0	2	2	2	2	1	3	3	3	1	3	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:156821804G>A	uc010pht.1	-	3	1071	c.817C>T	c.(817-819)CGC>TGC	p.R273C	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc009wsj.1_Missense_Mutation_p.R273C	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	273					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTGACACAGCGCCAGGACTCA	0.662													10	32					0	0	0	0	A	156821804	A	A	156821804	3	1	201	1	0	0	0	0	1	0	0	0	7813	1087	38	1	3155	1	INSRR	1	156821804	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	7036753	156821804	92428817	19	36798											
PIGM	93183	broad.mit.edu	37	chr1	160001446	160001446	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagaaaaccagggcgactctGgctagaaaggccacaccaaa	16	4	10	11	1	1	2	0	0	1	2	1	3	1	2	3	3	1	1	3	3	6	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:160001446G>A	uc001fuv.1	-	1	338	c.84C>T	c.(82-84)GCC>GCT	p.A28A		NM_145167	NP_660150	Q9H3S5	PIGM_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	28	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGGCGACTCTGGCTAGAAAGG	0.607													30	77					0	0	0	0	A	160001446	A	A	160001446	2	1	201	1	0	0	0	0	0	0	0	1	11947	1335	47	4		4	PIGM	1	160001446	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	3179642	160001446	89249175	20	36799											
ALDH9A1	223	broad.mit.edu	37	chr1	165664528	165664528	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaaaaggattcggcaacgCtccatgccagatttttgact	11	11	8	11	2	0	2	0	1	0	1	3	3	2	3	3	2	2	2	3	2	3	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:165664528C>A	uc001gdh.1	-	2	393	c.288G>T	c.(286-288)GAG>GAT	p.E96D	ALDH9A1_uc010pky.1_Missense_Mutation_p.E2D|ALDH9A1_uc010pkz.1_Missense_Mutation_p.E86D|ALDH9A1_uc010pla.1_Missense_Mutation_p.E2D	NM_000696	NP_000687	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9A1	72					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	TTCGGCAACGCTCCATGCCAG	0.398													18	34					3.52763e-06	5.29145e-06	1	0	A	165664528	A	A	165664528	3	1	201	1	0	0	0	0	1	0	0	0	506	796	28	4	1308	4	ALDH9A1	1	165664528	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	5663082	165664528	83586093	21	36800											
ILDR2	387597	broad.mit.edu	37	chr1	166891884	166891884	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actccatggctgagggcccgCggcttgccccactgctgcct	4	8	12	17	2	0	1	0	1	0	0	1	1	1	1	5	3	3	3	5	3	0	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:166891884C>T	uc001gdx.1	-	8	1213	c.1157G>A	c.(1156-1158)CGC>CAC	p.R386H		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	386	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						TGAGGGCCCGCGGCTTGCCCC	0.582													47	225					0	0	0	0	T	166891884	T	T	166891884	3	4	201	1	0	0	0	0	1	0	0	0	7749	768	27	1	774	1	ILDR2	1	166891884	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1227356	166891884	82358737	22	36801											
CACNA1E	777	broad.mit.edu	37	chr1	181727186	181727186	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcactttgtggtgtctcCgtcctttgagtacaccatta	6	15	10	10	1	1	1	0	1	1	0	3	1	2	1	3	2	1	2	3	2	2	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:181727186C>T	uc001gow.2	+	31	4598	c.4433C>T	c.(4432-4434)CCG>CTG	p.P1478L	CACNA1E_uc009wxs.2_Missense_Mutation_p.P1366L|CACNA1E_uc001gox.1_Missense_Mutation_p.P704L|CACNA1E_uc009wxt.2_Missense_Mutation_p.P704L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1478	IV.|Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GTGGTGTCTCCGTCCTTTGAG	0.557													20	85					0	0	0	0	T	181727186	T	T	181727186	3	4	201	1	0	0	0	0	1	0	0	0	2554	652	23	1	4555	1	CACNA1E	1	181727186	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	14835302	181727186	67523435	23	36802											
FAM5C	339479	broad.mit.edu	37	chr1	190067931	190067941	+	Frame_Shift_Del	DEL	TCTGTCCGTTT	-	-																															atggcatggacttctattcgTctgtccgttttctgcagcag																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:190067931_190067941delTCTGTCCGTTT	uc001gse.1	-	8	1740_1750	c.1508_1518delAAACGGACAGA	c.(1507-1518)AAAACGGACAGAfs	p.K503fs	FAM5C_uc010pot.1_Frame_Shift_Del_p.K401fs	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	503_506						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CTTCTATTCGTCTGTCCGTTTTCTGCAGCAG	0.498													---	---	---								-	190067941	-	-	190067931	7	5	201	1	0	1	0	1	0	0	0	0	5626	1664	58	0	786	0	FAM5C	1	190067931	Frame_Shift_Del	DEL	TCTGTCCGTTT	TCGA-CV-6942-01A-21D-2012-08	8340745	190067931	59182690	24	36803											
ATP2B4	493	broad.mit.edu	37	chr1	203696681	203696681	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctggttccggggcctGaaccgtatccagactcaggt	7	10	11	13	2	2	2	1	1	1	1	5	2	5	2	5	4	1	2	5	4	2	2	rs113186728	byFrequency	TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:203696681G>A	uc001gzw.2	+	20	4175	c.3291G>A	c.(3289-3291)CTG>CTA	p.L1097L	ATP2B4_uc001gzv.2_Silent_p.L1097L|ATP2B4_uc009xaq.2_Silent_p.L1097L|ATP2B4_uc001gzx.2_Silent_p.L128L|ATP2B4_uc009xar.2_Silent_p.L92L|ATP2B4_uc010pqj.1_RNA|uc010pqk.1_5'Flank|SNORA77_uc001gzy.1_5'Flank	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1097	Cytoplasmic (Potential).|Calmodulin-binding subdomain A.				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TCCGGGGCCTGAACCGTATCC	0.562													32	75					0	0	0	0	A	203696681	A	A	203696681	2	1	201	1	0	0	0	0	0	0	0	1	1144	1277	45	2		2	ATP2B4	1	203696681	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	13628750	203696681	45553940	25	36804											
VASH2	79805	broad.mit.edu	37	chr1	213147383	213147383	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agaaggagacaggcaagcccCccgaggaggctcggccggcg	10	1	17	13	4	0	2	0	0	0	2	1	5	0	3	4	6	1	2	4	6	2	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:213147383C>T	uc001hjy.2	+	6	1170	c.966C>T	c.(964-966)CCC>CCT	p.P322P	VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Silent_p.P257P|VASH2_uc010ptn.1_Silent_p.P218P|VASH2_uc001hjw.2_Silent_p.P278P	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3	322					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		AGGCAAGCCCCCCGAGGAGGC	0.577													5	56					0	0	0	0	T	213147383	T	T	213147383	2	4	201	1	0	0	0	0	0	0	0	1	17194	610	22	4		4	VASH2	1	213147383	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	9450702	213147383	36103238	26	36805											
FAM89A	375061	broad.mit.edu	37	chr1	231155686	231155686	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtcccgaggagggcctcggtCcctcctgtcgtgcagggagt	4	8	16	13	3	0	0	0	0	0	0	5	3	3	2	4	4	1	1	4	4	0	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr1:231155686C>G	uc001hui.2	-	2	516	c.478G>C	c.(478-480)GAC>CAC	p.D160H	FAM89A_uc009xfm.2_Missense_Mutation_p.D171H|MIR1182_hsa-mir-1182|MI0006275_5'Flank	NM_198552	NP_940954	Q96GI7	FA89A_HUMAN	family with sequence similarity 89, member A	160											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GGGCCTCGGTCCCTCCTGTCG	0.587													27	66					0	0	0	0	G	231155686	G	G	231155686	3	3	201	1	0	0	0	0	1	0	0	0	5679	855	30	2	80	2	FAM89A	1	231155686	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	18008303	231155686	18094935	27	36806											
C2orf50	130813	broad.mit.edu	37	chr2	11284117	11284117	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacacagttcccagttccacGaaccaggttgtgggcagcag	10	7	12	12	1	0	0	0	0	0	0	2	2	2	0	3	2	2	5	3	2	1	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:11284117G>A	uc010yji.1	+	3	651	c.369G>A	c.(367-369)ACG>ACA	p.T123T	C2orf50_uc010yjj.1_Silent_p.T123T	NM_182500	NP_872306	Q96LR7	CB050_HUMAN	hypothetical protein LOC130813	123											0	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0997)|OV - Ovarian serous cystadenocarcinoma(76;0.134)		CCAGTTCCACGAACCAGGTTG	0.582													10	61					0	0	0	0	A	11284117	A	A	11284117	2	1	201	1	0	0	0	0	0	0	0	1	2182	1045	37	1		1	C2orf50	2	11284117	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08		11284117	231915256	28	36807											
NBAS	51594	broad.mit.edu	37	chr2	15629092	15629092	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcagtttccctgagaagtGaatggctgccaggagcatcc	9	9	12	11	0	1	2	1	2	0	1	3	4	3	3	3	2	2	4	3	2	2	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:15629092G>A	uc002rcc.1	-	12	1035	c.1009C>T	c.(1009-1011)CAC>TAC	p.H337Y	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	337	WD 2.									ovary(2)|liver(1)|skin(1)	4						CCTGAGAAGTGAATGGCTGCC	0.448													14	62					0	0	0	0	A	15629092	A	A	15629092	3	1	201	1	0	0	0	0	1	0	0	0	10239	1290	45	2	6270	2	NBAS	2	15629092	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	4344975	15629092	227570281	29	36808											
TTC32	130502	broad.mit.edu	37	chr2	20101573	20101573	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgttgaaatgagcctgggCgagtgttagggttgcgtggc	7	12	17	5	2	0	2	0	2	0	0	0	3	0	2	1	3	2	3	1	3	2	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:20101573C>T	uc002rdg.2	-	1	175	c.43G>A	c.(43-45)GCC>ACC	p.A15T		NM_001008237	NP_001008238	Q5I0X7	TTC32_HUMAN	tetratricopeptide repeat domain 32	15	TPR 1.						identical protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGAGCCTGGGCGAGTGTTAGG	0.597													10	82					0	0	0	0	T	20101573	T	T	20101573	3	4	201	1	0	0	0	0	1	0	0	0	16769	768	27	1	424	1	TTC32	2	20101573	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	4472481	20101573	223097800	30	36809											
APOB	338	broad.mit.edu	37	chr2	21230369	21230369	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaggaatgtttaagaaaTccagatttgcttctccattt	13	16	6	6	0	1	2	0	0	1	2	3	3	2	3	2	1	1	2	2	1	5	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:21230369T>C	uc002red.2	-	26	9499	c.9371A>G	c.(9370-9372)GAT>GGT	p.D3124G		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3124					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTTTAAGAAATCCAGATTTGC	0.378													19	84					0	0	0	0	C	21230369	C	C	21230369	3	2	201	1	0	0	0	0	1	0	0	0	785	1435	50	5	4336	5	APOB	2	21230369	Missense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08	1128796	21230369	221969004	31	36810											
OTOF	9381	broad.mit.edu	37	chr2	26688665	26688665	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagtcatacacagccacCgtcagcatggattccatggg	10	8	9	14	1	2	0	2	0	0	0	4	1	4	1	4	2	3	1	4	2	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:26688665C>A	uc002rhk.2	-	38	4801	c.4674G>T	c.(4672-4674)ACG>ACT	p.T1558T	OTOF_uc010yla.1_Silent_p.T288T|OTOF_uc002rhh.2_Silent_p.T791T|OTOF_uc002rhi.2_Silent_p.T868T|OTOF_uc002rhj.2_Silent_p.T791T	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1558	Cytoplasmic (Potential).|C2 4.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACACAGCCACCGTCAGCATGG	0.572													11	51					1.08611e-07	1.65815e-07	1	0	A	26688665	A	A	26688665	2	1	201	1	0	0	0	0	0	0	0	1	11357	639	23	3		3	OTOF	2	26688665	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	5458296	26688665	216510708	32	36811											
C2orf53	339779	broad.mit.edu	37	chr2	27360067	27360067	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttttggtgcccgaggtggAggcccggagaaacatcgtgg	7	9	17	8	3	0	1	0	0	0	1	1	4	0	2	2	6	2	1	2	6	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:27360067A>G	uc002rjb.2	-	3	1711	c.1131T>C	c.(1129-1131)CCT>CCC	p.P377P	PREB_uc002rix.1_5'Flank|PREB_uc002riy.1_5'Flank|PREB_uc002riz.1_5'Flank|PREB_uc002rja.1_5'Flank	NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	377											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCGAGGTGGAGGCCCGGAGA	0.607													3	111					0	0	0	0	G	27360067	G	G	27360067	2	3	201	1	0	0	0	0	0	0	0	1	2184	291	11	5		5	C2orf53	2	27360067	Silent	SNP	A	TCGA-CV-6942-01A-21D-2012-08	671402	27360067	215839306	33	36812											
RBKS	64080	broad.mit.edu	37	chr2	28050554	28050554	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacctggcagccccttttCaagagcactaatgcagcctc	10	8	7	16	0	1	1	1	0	0	1	2	1	1	1	5	1	4	3	5	1	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:28050554C>A	uc002rlo.1	-	7	686	c.675G>T	c.(673-675)TTG>TTT	p.L225F	RBKS_uc010ezi.1_Missense_Mutation_p.L158F|RBKS_uc010ymg.1_Missense_Mutation_p.L225F	NM_022128	NP_071411	Q9H477	RBSK_HUMAN	ribokinase	225					D-ribose metabolic process		ATP binding|ribokinase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)					AGCCCCTTTTCAAGAGCACTA	0.512													17	60					2.23348e-06	3.36198e-06	1	0	A	28050554	A	A	28050554	3	1	201	1	0	0	0	0	1	0	0	0	13173	825	29	2	301	2	RBKS	2	28050554	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	690487	28050554	215148819	34	36813											
EPCAM	4072	broad.mit.edu	37	chr2	47604194	47604194	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgcgttatcaactggatcCaaaatttatcacgagtattt	14	13	6	8	3	2	0	2	0	0	0	3	2	3	1	1	1	2	2	1	1	7	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:47604194C>A	uc002rvx.2	+	5	891	c.533C>A	c.(532-534)CCA>CAA	p.P178Q	EPCAM_uc002rvw.2_Missense_Mutation_p.P206Q|MIR559_hsa-mir-559|MI0003565_5'Flank	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	178	Extracellular (Potential).				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						CAACTGGATCCAAAATTTATC	0.333									Lynch_syndrome				12	53					1.61879e-10	2.56259e-10	1	0	A	47604194	A	A	47604194	3	1	201	1	0	0	0	0	1	0	0	0	5186	594	21	4	551	4	EPCAM	2	47604194	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	19553640	47604194	195595179	35	36814											
ASB3	51130	broad.mit.edu	37	chr2	53927562	53927562	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctttcctcaaaaagtagcGaaatatcgaaaacttctcgt	15	11	5	10	3	2	0	1	0	1	0	5	2	3	0	2	0	2	1	2	0	7	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:53927562G>A	uc002rxg.1	-	8	1219	c.1084C>T	c.(1084-1086)CGC>TGC	p.R362C	ASB3_uc002rxh.1_Missense_Mutation_p.R289C|ASB3_uc002rxi.3_Missense_Mutation_p.R400C|ASB3_uc002rxf.1_RNA	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	362	ANK 11.				intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AAAAAGTAGCGAAATATCGAA	0.353													7	72					0	0	0	0	A	53927562	A	A	53927562	3	1	201	1	0	0	0	0	1	0	0	0	1026	1058	37	1	484	1	ASB3	2	53927562	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	6323368	53927562	189271811	36	36815											
BCL11A	53335	broad.mit.edu	37	chr2	60687704	60687704	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcctggtgagcttgctactCtgggcacaggcatagttgca	7	11	13	10	0	1	1	0	1	1	0	1	1	1	1	1	3	5	6	1	3	2	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:60687704C>G	uc002sae.1	-	4	2571	c.2343G>C	c.(2341-2343)CAG>CAC	p.Q781H	BCL11A_uc002sab.2_Intron|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Missense_Mutation_p.Q747H|BCL11A_uc002sad.1_Missense_Mutation_p.Q629H|BCL11A_uc002saf.1_Missense_Mutation_p.Q747H	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	781	C2H2-type 5.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GCTTGCTACTCTGGGCACAGG	0.493			T	IGH@	B-CLL								22	71					0	0	0	0	G	60687704	G	G	60687704	3	3	201	1	0	0	0	0	1	0	0	0	1365	912	32	2	274	2	BCL11A	2	60687704	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	6760142	60687704	182511669	37	36816											
USP34	9736	broad.mit.edu	37	chr2	61483552	61483552	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtactttcttcccacaatgaGaacaagtatacatgttatca	14	13	5	9	0	2	1	1	1	1	1	3	2	3	1	1	0	3	3	1	0	7	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:61483552G>C	uc002sbe.2	-	48	6210	c.6188C>G	c.(6187-6189)TCT>TGT	p.S2063C	USP34_uc002sbf.2_Missense_Mutation_p.S213C	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	2063					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CCCACAATGAGAACAAGTATA	0.313													9	44					0	0	0	0	C	61483552	C	C	61483552	3	2	201	1	0	0	0	0	1	0	0	0	17133	942	33	2	4584	2	USP34	2	61483552	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	795848	61483552	181715821	38	36817											
CLEC4F	165530	broad.mit.edu	37	chr2	71043722	71043722	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgggtcctcaagtcattgAcactatctagatggcctctc	8	13	8	12	0	5	2	2	1	3	1	7	2	6	2	2	2	0	0	2	2	3	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:71043722A>G	uc002shf.2	-	4	868	c.791T>C	c.(790-792)GTC>GCC	p.V264A	CLEC4F_uc010yqv.1_Missense_Mutation_p.V264A	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	264	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						CAAGTCATTGACACTATCTAG	0.428													29	85					0	0	0	0	G	71043722	G	G	71043722	3	3	201	1	0	0	0	0	1	0	0	0	3531	275	10	5	994	5	CLEC4F	2	71043722	Missense_Mutation	SNP	A	TCGA-CV-6942-01A-21D-2012-08	9560170	71043722	172155651	39	36818											
TSGA10	80705	broad.mit.edu	37	chr2	99695250	99695250	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgctgatttcttctcgctGtgcaatattttgccttgtaa	8	18	7	8	1	2	1	0	1	2	0	3	1	2	1	1	0	3	4	1	0	4	7			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:99695250G>C	uc002szg.3	-	10	1382	c.754C>G	c.(754-756)CAG>GAG	p.Q252E	TSGA10_uc002szh.3_Missense_Mutation_p.Q252E|TSGA10_uc002szi.3_Missense_Mutation_p.Q252E|TSGA10_uc010fin.1_Missense_Mutation_p.Q252E|TSGA10_uc010yvn.1_Missense_Mutation_p.Q252E	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	252					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						TCTTCTCGCTGTGCAATATTT	0.328													4	32					0	0	0	0	C	99695250	C	C	99695250	3	2	201	1	0	0	0	0	1	0	0	0	16684	1386	48	4	1382	4	TSGA10	2	99695250	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	28651528	99695250	143504123	40	36819											
IL18R1	8809	broad.mit.edu	37	chr2	102984411	102984411	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtacaaaagcagtggatCacaggaacatgtggagctga	14	7	13	7	0	1	1	1	1	0	0	1	4	1	4	0	4	4	3	0	4	4	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:102984411C>T	uc002tbw.3	+	3	335	c.185C>T	c.(184-186)TCA>TTA	p.S62L	IL18R1_uc010ywb.1_Missense_Mutation_p.S62L|IL18R1_uc010ywc.1_Missense_Mutation_p.S62L|IL18R1_uc010ywd.1_Intron|IL18R1_uc010fiy.2_Missense_Mutation_p.S62L	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	62	Ig-like C2-type 1.|Extracellular (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						AGCAGTGGATCACAGGAACAT	0.443													15	45					0	0	0	0	T	102984411	T	T	102984411	3	4	201	1	0	0	0	0	1	0	0	0	7686	838	29	2	191	2	IL18R1	2	102984411	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	3289161	102984411	140214962	41	36820											
HS6ST1	9394	broad.mit.edu	37	chr2	129025882	129025882	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctccctgcgctccagctGccgcttgtactggtagcgct	3	11	11	16	3	0	0	0	0	0	0	2	0	2	0	3	1	6	7	3	1	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:129025882G>A	uc002tpt.3	-	2	1124	c.1090C>T	c.(1090-1092)CAG>TAG	p.Q364*		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	364	Potential.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		CGCTCCAGCTGCCGCTTGTAC	0.672													20	50					0	0	0	0	A	129025882	A	A	129025882	4	1	201	1	0	0	0	0	0	1	0	0	7409	1328	46	4	149	4	HS6ST1	2	129025882	Nonsense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	26041471	129025882	114173491	42	36821											
MGAT5	4249	broad.mit.edu	37	chr2	135093845	135093845	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaatccctacgaagaagctGatcataattcattggtaagt	16	11	7	7	1	2	2	2	1	0	1	3	3	3	2	1	1	2	2	1	1	7	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:135093845G>A	uc002ttv.1	+	5	776	c.631G>A	c.(631-633)GAT>AAT	p.D211N		NM_002410	NP_002401	Q09328	MGT5A_HUMAN	N-acetylglucosaminyltransferase V	211	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0964)		CGAAGAAGCTGATCATAATTC	0.363													11	20					0	0	0	0	A	135093845	A	A	135093845	3	1	201	1	0	0	0	0	1	0	0	0	9601	1290	45	2	649	2	MGAT5	2	135093845	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	6067963	135093845	108105528	43	36822											
KIF5C	3800	broad.mit.edu	37	chr2	149793866	149793866	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgatatctttgaccatatCtactccatggatgagaacct	12	13	6	10	0	2	3	0	3	2	1	3	5	3	4	3	1	2	0	3	1	4	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:149793866C>G	uc010zbu.1	+	4	728	c.360C>G	c.(358-360)ATC>ATG	p.I120M		NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	120	Kinesin-motor.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		TTGACCATATCTACTCCATGG	0.483													2	7					0	0	0	0	G	149793866	G	G	149793866	3	3	201	1	0	0	0	0	1	0	0	0	8346	903	32	2	296	2	KIF5C	2	149793866	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	14700021	149793866	93405507	44	36823											
NFE2L2	4780	broad.mit.edu	37	chr2	178095623	178095623	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataaggttttccatcttcatCacgtagcatgctgaaaactt	12	14	6	9	1	3	1	2	1	1	0	4	1	4	1	1	1	3	4	1	1	4	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:178095623C>T	uc002ulh.3	-	5	2263	c.1708G>A	c.(1708-1710)GAT>AAT	p.D570N	NFE2L2_uc002ulg.3_Missense_Mutation_p.D554N|NFE2L2_uc010zfa.1_Missense_Mutation_p.D547N|NFE2L2_uc002uli.3_Missense_Mutation_p.D554N	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	570					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			CCATCTTCATCACGTAGCATG	0.378			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			18	107					0	0	0	0	T	178095623	T	T	178095623	3	4	201	1	0	0	0	0	1	0	0	0	10422	826	29	2	113	2	NFE2L2	2	178095623	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	28301757	178095623	65103750	45	36824											
TTN	7273	broad.mit.edu	37	chr2	179397871	179397871	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtgtcagtggtacactttCagttccagaaagaatttcag	11	13	9	8	0	3	2	3	0	0	2	4	2	4	2	1	1	1	2	1	1	3	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:179397871C>G	uc010zfg.1	-	307	95991	c.95767G>C	c.(95767-95769)GAA>CAA	p.E31923Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E25618Q|TTN_uc010zfi.1_Missense_Mutation_p.E25551Q|TTN_uc010zfj.1_Missense_Mutation_p.E25426Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32850							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTACACTTTCAGTTCCAGAA	0.433													41	131					0	0	0	0	G	179397871	G	G	179397871	3	3	201	1	0	0	0	0	1	0	0	0	16803	835	29	2	4528	2	TTN	2	179397871	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1302248	179397871	63801502	46	36825											
PGAP1	80055	broad.mit.edu	37	chr2	197767387	197767387	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaacttggtaatcccggaaTcctccagctacagaaagtgt	12	9	9	11	2	0	1	0	0	0	1	3	3	3	2	3	2	3	2	3	2	5	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:197767387T>A	uc002utw.2	-	5	843	c.729A>T	c.(727-729)GGA>GGT	p.G243G	PGAP1_uc002utx.2_Silent_p.G69G|PGAP1_uc002uty.1_Silent_p.G243G|PGAP1_uc010zgv.1_RNA|PGAP1_uc010fsj.2_Silent_p.G69G	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	243	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						AATCCCGGAATCCTCCAGCTA	0.358													14	54					0	0	0	0	A	197767387	A	A	197767387	2	1	201	1	0	0	0	0	0	0	0	1	11832	1422	50	5		5	PGAP1	2	197767387	Silent	SNP	T	TCGA-CV-6942-01A-21D-2012-08	18369516	197767387	45431986	47	36826											
HSPD1	3329	broad.mit.edu	37	chr2	198363463	198363463	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccttgaagcattaaggctCgggcatctgcaccaaatttt	11	11	8	11	1	1	1	0	1	1	0	2	1	1	1	2	2	2	4	2	2	3	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:198363463C>T	uc002uui.2	-	2	247	c.110G>A	c.(109-111)CGA>CAA	p.R37Q	HSPD1_uc002uuj.2_Missense_Mutation_p.R37Q|HSPD1_uc010zgx.1_Missense_Mutation_p.R37Q|HSPD1_uc010fsm.2_5'UTR|HSPD1_uc002uuk.2_Missense_Mutation_p.R37Q|HSPD1_uc010zgy.1_Missense_Mutation_p.R37Q|HSPE1_uc002uul.2_5'Flank	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	37					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			CATTAAGGCTCGGGCATCTGC	0.463													16	85					0	0	0	0	T	198363463	T	T	198363463	3	4	201	1	0	0	0	0	1	0	0	0	7467	884	31	1	1655	1	HSPD1	2	198363463	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	596076	198363463	44835910	48	36827											
MARS2	92935	broad.mit.edu	37	chr2	198570406	198570406	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgcgattctccactggtaccGacgagcacgggctgaagatt	9	8	12	12	5	1	2	0	1	1	1	2	5	1	2	2	2	2	3	2	2	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:198570406G>C	uc002uuq.2	+	1	320	c.277G>C	c.(277-279)GAC>CAC	p.D93H	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	93					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	CACTGGTACCGACGAGCACGG	0.667													8	26					0	0	0	0	C	198570406	C	C	198570406	3	2	201	1	0	0	0	0	1	0	0	0	9370	1058	37	3	279	3	MARS2	2	198570406	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	206943	198570406	44628967	49	36828											
MARS2	92935	broad.mit.edu	37	chr2	198570421	198570421	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaccgacgagcacgggctgAagattcagcaggcagcagct	11	5	14	11	3	1	2	1	1	0	1	1	4	1	2	1	2	5	7	1	2	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:198570421A>C	uc002uuq.2	+	1	335	c.292A>C	c.(292-294)AAG>CAG	p.K98Q	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	98					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	GCACGGGCTGAAGATTCAGCA	0.672													8	31					0	0	0	0	C	198570421	C	C	198570421	3	2	201	1	0	0	0	0	1	0	0	0	9370	247	9	5	294	5	MARS2	2	198570421	Missense_Mutation	SNP	A	TCGA-CV-6942-01A-21D-2012-08	15	198570421	44628952	50	36829											
CXCR2	3579	broad.mit.edu	37	chr2	218999995	218999995	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccacacgcacactgacccaGaagcgctacttggtcaaatt	12	7	8	14	2	1	2	1	1	0	1	1	2	1	2	2	1	2	2	2	1	3	3	rs146545386		TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:218999995G>C	uc002vgz.1	+	4	696	c.471G>C	c.(469-471)CAG>CAC	p.Q157H	CXCR2_uc002vha.1_Missense_Mutation_p.Q157H|CXCR2_uc002vhb.1_Missense_Mutation_p.Q157H	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	157	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						CACTGACCCAGAAGCGCTACT	0.527													15	36					0	0	0	0	C	218999995	C	C	218999995	3	2	201	1	0	0	0	0	1	0	0	0	4108	933	33	2	473	2	CXCR2	2	218999995	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	20429574	218999995	24199378	51	36830											
CXCR2	3579	broad.mit.edu	37	chr2	219000052	219000052	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggggtctgtccttgctcctGgccctgcctgtcttactttt	1	17	10	13	0	2	0	0	0	2	0	4	0	4	0	4	3	3	1	4	3	1	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:219000052G>A	uc002vgz.1	+	4	753	c.528G>A	c.(526-528)CTG>CTA	p.L176L	CXCR2_uc002vha.1_Silent_p.L176L|CXCR2_uc002vhb.1_Silent_p.L176L	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	176	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						CCTTGCTCCTGGCCCTGCCTG	0.532													18	32					0	0	0	0	A	219000052	A	A	219000052	2	1	201	1	0	0	0	0	0	0	0	1	4108	1335	47	4		4	CXCR2	2	219000052	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	57	219000052	24199321	52	36831											
IRS1	3667	broad.mit.edu	37	chr2	227664844	227664844	+	5'Flank	DEL	G	-	-																															gaagacgcaggagtgagggtGgggggccacgggggggcact																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:227664844delG	uc002voh.3	-							NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1						fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GAGTGAGGGTGGGGGGCCACG	0.716													---	---	---								-	227664844	-	-	227664844	6	5	201	0	1	1	0	1	0	0	0	0	7879	1363	47	0		0	IRS1	2	227664844	5'Flank	DEL	G	TCGA-CV-6942-01A-21D-2012-08	8664792	227664844	15534529	53	36832											
TRIP12	9320	broad.mit.edu	37	chr2	230653558	230653558	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgttgggatgtttcctgtCatgattactaaaggatcttg	9	16	10	6	0	2	1	1	1	1	0	3	3	3	3	1	2	1	2	1	2	3	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:230653558C>T	uc002vpw.1	-	31	4678	c.4569G>A	c.(4567-4569)ATG>ATA	p.M1523I	TRIP12_uc002vpx.1_Missense_Mutation_p.M1571I|TRIP12_uc002vpy.1_Missense_Mutation_p.M1253I	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1523	K-box.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGTTTCCTGTCATGATTACTA	0.378													32	92					0	0	0	0	T	230653558	T	T	230653558	3	4	201	1	0	0	0	0	1	0	0	0	16623	826	29	2	1453	2	TRIP12	2	230653558	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	2988714	230653558	12545815	54	36833											
ATG16L1	55054	broad.mit.edu	37	chr2	234186223	234186223	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtcttgcaggatgcacatGatggggaagtcaacgctgtg	9	11	14	7	1	2	1	1	1	1	0	2	3	2	3	0	3	3	3	0	3	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:234186223G>A	uc002vty.2	+	10	1221	c.964G>A	c.(964-966)GAT>AAT	p.D322N	ATG16L1_uc002vtx.1_Missense_Mutation_p.D159N|ATG16L1_uc002vua.2_Missense_Mutation_p.D303N|ATG16L1_uc002vub.2_Missense_Mutation_p.D180N|ATG16L1_uc002vtz.2_Missense_Mutation_p.D178N|ATG16L1_uc002vud.3_Missense_Mutation_p.D238N	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	322	WD 1.				autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GGATGCACATGATGGGGAAGT	0.522													15	48					0	0	0	0	A	234186223	A	A	234186223	3	1	201	1	0	0	0	0	1	0	0	0	1093	1290	45	2	1002	2	ATG16L1	2	234186223	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	3532665	234186223	9013150	55	36834											
UGT1A8	54576	broad.mit.edu	37	chr2	234527112	234527112	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacatcaatttggttgttGcgaacagactttgttttgga	10	15	9	7	1	1	1	1	0	0	1	1	3	1	2	0	2	2	3	0	2	2	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:234527112G>A	uc002vup.2	+	1	822	c.759G>A	c.(757-759)TTG>TTA	p.L253L	UGT1A8_uc010zmv.1_Silent_p.L253L	NM_019076	NP_061949	Q9HAW9	UD18_HUMAN	UDP glycosyltransferase 1 family, polypeptide A8	253					drug metabolic process|fatty acid metabolic process|flavone metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme inhibitor activity|fatty acid binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|steroid binding			ovary(2)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTTGGTTGTTGCGAACAGACT	0.428													61	290					0	0	0	0	A	234527112	A	A	234527112	2	1	201	1	0	0	0	0	0	0	0	1	17019	1310	46	4		4	UGT1A8	2	234527112	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	340889	234527112	8672261	56	36835											
PASK	23178	broad.mit.edu	37	chr2	242065973	242065973	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggacacacgacccctgtTcctggagactgcctacatct	9	8	8	16	1	1	1	0	0	1	1	2	4	2	2	5	2	2	1	5	2	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr2:242065973T>C	uc002wao.1	-	10	2449	c.2357A>G	c.(2356-2358)GAA>GGA	p.E786G	PASK_uc010zol.1_Missense_Mutation_p.E600G|PASK_uc010zom.1_Missense_Mutation_p.E751G|PASK_uc010fzl.1_Missense_Mutation_p.E786G|PASK_uc010zon.1_Missense_Mutation_p.E567G|PASK_uc002wap.2_Missense_Mutation_p.E329G|PASK_uc002waq.2_Missense_Mutation_p.E786G	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	786					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CGACCCCTGTTCCTGGAGACT	0.567													22	65					0	0	0	0	C	242065973	C	C	242065973	3	2	201	1	0	0	0	0	1	0	0	0	11526	1783	62	5	1650	5	PASK	2	242065973	Missense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08	7538861	242065973	1133400	57	36836											
SYN2	6854	broad.mit.edu	37	chr3	12209896	12209896	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtacaaactgtgggtggacaCctgctctgagatgtttggcg	8	11	14	8	1	1	1	0	1	1	1	1	3	1	2	1	3	3	3	1	3	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:12209896C>T	uc003bwm.2	+	13	1240	c.1076C>T	c.(1075-1077)ACC>ATC	p.T359I	SYN2_uc003bwl.1_Missense_Mutation_p.T359I|SYN2_uc003bwn.2_Missense_Mutation_p.T33I	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	359					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						TGGGTGGACACCTGCTCTGAG	0.522													9	20					0	0	0	0	T	12209896	T	T	12209896	3	4	201	1	0	0	0	0	1	0	0	0	15507	507	18	4	1111	4	SYN2	3	12209896	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08		12209896	185812534	58	36837											
DYNC1LI1	51143	broad.mit.edu	37	chr3	32612233	32612233	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatcccggcggagaagaaccGaaggagccgactcgccccac	12	2	12	15	5	0	2	0	0	0	2	2	6	1	3	5	3	2	0	5	3	4	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:32612233G>A	uc003cfb.3	-	1	118	c.30C>T	c.(28-30)TTC>TTT	p.F10F	DYNC1LI1_uc011axh.1_Silent_p.F10F	NM_016141	NP_057225	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain	10					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			ovary(1)	1						GAGAAGAACCGAAGGAGCCGA	0.672													5	21					0	0	0	0	A	32612233	A	A	32612233	2	1	201	1	0	0	0	0	0	0	0	1	4866	1049	37	1		1	DYNC1LI1	3	32612233	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	20402337	32612233	165410197	59	36838											
SCN11A	11280	broad.mit.edu	37	chr3	38991702	38991702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttaggtcaagctgaggcCgaggctggggtacttctcct	6	11	13	11	1	2	1	1	1	1	0	3	2	2	1	3	5	2	3	3	5	3	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:38991702C>T	uc011ays.1	-	1	351	c.152G>A	c.(151-153)CGG>CAG	p.R51Q		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	51					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAGCTGAGGCCGAGGCTGGGG	0.522													13	157					0	0	0	0	T	38991702	T	T	38991702	3	4	201	1	0	0	0	0	1	0	0	0	13978	652	23	1	5327	1	SCN11A	3	38991702	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	6379469	38991702	159030728	60	36839											
XIRP1	165904	broad.mit.edu	37	chr3	39227860	39227860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agactgccatccctttctgtCcagagtgactgtcttcctgc	6	13	8	14	0	2	3	0	1	2	2	5	3	5	3	4	0	2	0	4	0	0	2	rs139499086	by1000genomes	TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:39227860C>G	uc003cjk.1	-	2	3298	c.3077G>C	c.(3076-3078)GGA>GCA	p.G1026A	XIRP1_uc003cji.2_Missense_Mutation_p.G1026A|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1026							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCCTTTCTGTCCAGAGTGACT	0.607													14	56					0	0	0	0	G	39227860	G	G	39227860	3	3	201	1	0	0	0	0	1	0	0	0	17497	855	30	2	2458	2	XIRP1	3	39227860	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	236158	39227860	158794570	61	36840											
CTNNB1	1499	broad.mit.edu	37	chr3	41266590	41266590	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgtttggctgaaccatcAcagatgctgaaacatgcagt	12	9	10	10	1	1	3	1	2	0	1	1	3	1	3	1	1	5	4	1	1	2	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:41266590A>G	uc010hia.1	+	5	543	c.387A>G	c.(385-387)TCA>TCG	p.S129S	CTNNB1_uc003ckp.2_Silent_p.S129S|CTNNB1_uc003ckq.2_Silent_p.S129S|CTNNB1_uc003ckr.2_Silent_p.S129S|CTNNB1_uc011azf.1_Silent_p.S122S|CTNNB1_uc011azg.1_Silent_p.S57S|uc010hib.1_5'Flank	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	129					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.A5_Q143del(7)|p.Q28_H134del(5)|p.W25_I140del(4)|p.V22_L139>V(2)|p.M5_N141>D(2)|p.L10_N141del(2)|p.A5_Y142>D(2)|p.A20_Q143del(1)|p.A5_Q143>E(1)|p.A13_R151del(1)|p.S23_I140del(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.I35_K170del(1)|p.D6_K133del(1)|p.M1_V173del(1)|p.E15_I140>V(1)|p.H24_M131del(1)|p.A5_D144>D(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.A20_L148del(1)|p.E9_I140del(1)|p.P16_K133del(1)|p.D6_I140del(1)|p.Q28_I140del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	CTGAACCATCACAGATGCTGA	0.448		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				15	48					0	0	0	0	G	41266590	G	G	41266590	2	3	201	1	0	0	0	0	0	0	0	1	4033	146	6	5		5	CTNNB1	3	41266590	Silent	SNP	A	TCGA-CV-6942-01A-21D-2012-08	2038730	41266590	156755840	62	36841											
TRAK1	22906	broad.mit.edu	37	chr3	42229593	42229593	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgcttcagttctacacCagcgctgcggaggagagtga	9	8	14	10	2	2	2	1	1	1	1	2	5	2	3	1	2	5	4	1	2	1	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:42229593C>T	uc003cky.2	+	5	753	c.537C>T	c.(535-537)ACC>ACT	p.T179T	TRAK1_uc011azh.1_Silent_p.T179T|TRAK1_uc011azi.1_Silent_p.T179T|TRAK1_uc003ckz.3_Silent_p.T105T|TRAK1_uc011azj.1_Silent_p.T105T|TRAK1_uc003cla.2_Silent_p.T121T	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	179	Potential.|HAP1 N-terminal.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						AGTTCTACACCAGCGCTGCGG	0.577													22	136					0	0	0	0	T	42229593	T	T	42229593	2	4	201	1	0	0	0	0	0	0	0	1	16516	581	21	4		4	TRAK1	3	42229593	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	963003	42229593	155792837	63	36842											
LZTFL1	54585	broad.mit.edu	37	chr3	45874556	45874556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattaccttgtttaggagttCtgctgttccaccttcattaa	8	18	6	9	0	2	0	1	0	1	0	3	1	3	1	3	1	2	4	3	1	4	9			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:45874556C>T	uc003cox.1	-	5	580	c.442G>A	c.(442-444)GAA>AAA	p.E148K	LZTFL1_uc003coy.1_Missense_Mutation_p.E131K|LZTFL1_uc011bak.1_RNA	NM_020347	NP_065080	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	148	Potential.										0				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		TTTAGGAGTTCTGCTGTTCCA	0.383													9	80					0	0	0	0	T	45874556	T	T	45874556	3	4	201	1	0	0	0	0	1	0	0	0	9187	922	32	2	481	2	LZTFL1	3	45874556	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	3644963	45874556	152147874	64	36843											
ABHD14A	25864	broad.mit.edu	37	chr3	52014456	52014456	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcaagcacagaggcagggCgggcagcgctgctggagcgg	9	2	20	10	3	0	1	0	0	0	1	0	2	0	2	0	6	4	6	0	6	1	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:52014456C>T	uc003dco.2	+	4	555	c.445C>T	c.(445-447)CGG>TGG	p.R149W	ABHD14B_uc003dcn.2_Intron|ACY1_uc011bea.1_Intron	NM_015407	NP_056222	Q9BUJ0	ABHEA_HUMAN	abhydrolase domain containing 14A	149						cytoplasm|integral to membrane	hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AGAGGCAGGGCGGGCAGCGCT	0.637													25	45					0	0	0	0	T	52014456	T	T	52014456	3	4	201	1	0	0	0	0	1	0	0	0	79	759	27	1	459	1	ABHD14A	3	52014456	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	6139900	52014456	146007974	65	36844											
ROBO1	6091	broad.mit.edu	37	chr3	78696802	78696802	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggtgtgaaggtaaaagacGggactgaaaaatcaaaacaa	19	7	11	4	1	1	3	1	2	0	1	1	4	1	4	0	3	1	1	0	3	8	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:78696802G>C	uc003dqe.2	-	20	3024	c.2816C>G	c.(2815-2817)CCG>CGG	p.P939R	ROBO1_uc003dqb.2_Missense_Mutation_p.P900R|ROBO1_uc003dqc.2_Intron|ROBO1_uc003dqd.2_Intron|ROBO1_uc010hoh.2_Missense_Mutation_p.P131R|ROBO1_uc011bgl.1_Missense_Mutation_p.P511R	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	939	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GGTAAAAGACGGGACTGAAAA	0.343													61	232					0	0	0	0	C	78696802	C	C	78696802	3	2	201	1	0	0	0	0	1	0	0	0	13578	1116	39	3	2187	3	ROBO1	3	78696802	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	26682346	78696802	119325628	66	36845											
WDR52	55779	broad.mit.edu	37	chr3	113152421	113152421	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttacttacatcttgattCtgatttagaagacctcagag	11	16	6	8	0	4	5	1	2	3	3	4	5	4	5	1	0	2	0	1	0	4	7			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:113152421C>G	uc003eae.1	-	2	137	c.91G>C	c.(91-93)GAA>CAA	p.E31Q		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	31										central_nervous_system(1)	1						CATCTTGATTCTGATTTAGAA	0.313													17	65					0	0	0	0	G	113152421	G	G	113152421	3	3	201	1	0	0	0	0	1	0	0	0	17372	922	32	2	5624	2	WDR52	3	113152421	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	34455619	113152421	84870009	67	36846											
RABL3	285282	broad.mit.edu	37	chr3	120413005	120413005	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattgaaaccattaccttatCaaaaaacctactgagcttga	17	11	4	9	0	1	3	1	3	0	0	1	3	1	3	3	0	5	1	3	0	8	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:120413005C>G	uc003edx.2	-	6	631	c.601G>C	c.(601-603)GAT>CAT	p.D201H		NM_173825	NP_776186	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3	201	Small GTPase-like.				small GTPase mediated signal transduction		GTP binding				0				GBM - Glioblastoma multiforme(114;0.151)		ATTACCTTATCAAAAAACCTA	0.294													33	95					0	0	0	0	G	120413005	G	G	120413005	3	3	201	1	0	0	0	0	1	0	0	0	13037	826	29	2	121	2	RABL3	3	120413005	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	7260584	120413005	77609425	68	36847											
DIRC2	84925	broad.mit.edu	37	chr3	122514336	122514336	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctcgtgctgtgggggcccatCggcttcctgccctgcttcgc	1	11	13	16	3	0	0	0	0	0	0	4	0	1	0	3	3	3	3	3	3	0	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:122514336C>G	uc003efw.3	+	1	436	c.297C>G	c.(295-297)ATC>ATG	p.I99M	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Translation_Start_Site|HSPBAP1_uc003efu.1_5'Flank|HSPBAP1_uc003efv.1_5'Flank	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	99	Helical; (Potential).				transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		GGGGGCCCATCGGCTTCCTGC	0.692													5	23					0	0	0	0	G	122514336	G	G	122514336	3	3	201	1	0	0	0	0	1	0	0	0	4556	874	31	3	299	3	DIRC2	3	122514336	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	2101331	122514336	75508094	69	36848											
UBA5	79876	broad.mit.edu	37	chr3	132387716	132387716	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaatatgaatagacttttcTtccaacctcatcaagcagga	14	11	5	11	0	3	2	2	1	1	1	4	3	4	3	3	1	2	1	3	1	6	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:132387716T>A	uc003epa.3	+	4	594	c.352T>A	c.(352-354)TTC>ATC	p.F118I	NPHP3_uc003eoz.1_Intron|UBA5_uc010htr.2_Missense_Mutation_p.F62I|UBA5_uc010htt.2_Missense_Mutation_p.F118I|UBA5_uc003epb.3_Missense_Mutation_p.F62I	NM_024818	NP_079094	Q9GZZ9	UBA5_HUMAN	ubiquitin-activating enzyme 5 isoform 1	118					protein ufmylation	aggresome|cytoplasm|cytoplasm|nucleus	ATP binding|cofactor binding|metal ion binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding|UFM1 activating enzyme activity			kidney(1)	1						TAGACTTTTCTTCCAACCTCA	0.338													30	95					0	0	0	0	A	132387716	A	A	132387716	3	1	201	1	0	0	0	0	1	0	0	0	16898	1609	56	5	366	5	UBA5	3	132387716	Missense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08	9873380	132387716	65634714	70	36849											
PPP2R3A	5523	broad.mit.edu	37	chr3	135720623	135720623	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aacaggccttcacaggcataCccagggtcaagagaggatct	13	6	11	11	0	3	1	2	0	1	1	3	3	3	2	2	4	2	1	2	4	3	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:135720623C>A	uc003eqv.1	+	2	848	c.283C>A	c.(283-285)CCC>ACC	p.P95T	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	95					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						CACAGGCATACCCAGGGTCAA	0.423													9	45					7.48243e-07	1.13027e-06	1	0	A	135720623	A	A	135720623	3	1	201	1	0	0	0	0	1	0	0	0	12448	507	18	4	285	4	PPP2R3A	3	135720623	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	3332907	135720623	62301807	71	36850											
RASA2	5922	broad.mit.edu	37	chr3	141292835	141292835	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcaatacaattgtaaaatCaagtatgagctgccccactg	15	11	6	9	0	2	1	2	1	0	0	2	1	2	1	2	0	3	3	2	0	7	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:141292835C>G	uc003etz.1	+	14	1409	c.1409C>G	c.(1408-1410)TCA>TGA	p.S470*	RASA2_uc010huq.1_Nonsense_Mutation_p.S470*|RASA2_uc003eua.1_Nonsense_Mutation_p.S470*|RASA2_uc011bnc.1_Nonsense_Mutation_p.S62*	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	470	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						ATTGTAAAATCAAGTATGAGC	0.348													7	36					0	0	0	0	G	141292835	G	G	141292835	4	3	201	1	0	0	0	0	0	1	0	0	13126	838	29	2	1463	2	RASA2	3	141292835	Nonsense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	5572212	141292835	56729595	72	36851											
EIF4G1	1981	broad.mit.edu	37	chr3	184039136	184039136	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcccagagcatagcccttCagaatcccagccttcgtcgc	8	8	9	16	2	1	2	1	0	0	2	4	2	2	2	4	1	3	1	4	1	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr3:184039136C>T	uc003fnp.2	+	10	962	c.764C>T	c.(763-765)TCA>TTA	p.S255L	EIF4G1_uc003fno.1_Missense_Mutation_p.S196L|EIF4G1_uc010hxw.1_Missense_Mutation_p.S91L|EIF4G1_uc003fnt.2_5'UTR|EIF4G1_uc003fnq.2_Missense_Mutation_p.S168L|EIF4G1_uc003fnr.2_Missense_Mutation_p.S91L|EIF4G1_uc010hxx.2_Missense_Mutation_p.S262L|EIF4G1_uc003fns.2_Missense_Mutation_p.S215L|EIF4G1_uc010hxy.2_Missense_Mutation_p.S262L|EIF4G1_uc003fnv.3_Missense_Mutation_p.S255L|EIF4G1_uc003fnu.3_Missense_Mutation_p.S255L|EIF4G1_uc003fnw.2_Missense_Mutation_p.S262L|EIF4G1_uc003fnx.2_Missense_Mutation_p.S59L|EIF4G1_uc003fny.3_Missense_Mutation_p.S59L	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	255					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CATAGCCCTTCAGAATCCCAG	0.577													23	99					0	0	0	0	T	184039136	T	T	184039136	3	4	201	1	0	0	0	0	1	0	0	0	5060	838	29	2	794	2	EIF4G1	3	184039136	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	42746301	184039136	13983294	73	36852											
HS3ST1	9957	broad.mit.edu	37	chr4	11400946	11400946	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggaacctctcgaccttttgGatctcagggaaggggtccct	8	10	12	11	1	2	0	1	0	2	0	5	4	3	3	3	5	1	0	3	5	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr4:11400946G>A	uc003gmq.2	-	2	1007	c.684C>T	c.(682-684)ATC>ATT	p.I228I		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	228						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						CGACCTTTTGGATCTCAGGGA	0.557													6	28					0	0	0	0	A	11400946	A	A	11400946	2	1	201	1	0	0	0	0	0	0	0	1	7402	1164	41	2		2	HS3ST1	4	11400946	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08		11400946	179753330	74	36853											
ATP8A1	10396	broad.mit.edu	37	chr4	42416643	42416643	+	Splice_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataagaaactcaaatactcaCggagcagattttgttgcaag	16	10	8	7	1	2	2	2	0	0	2	2	3	2	3	0	1	4	3	0	1	5	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr4:42416643C>T	uc003gwr.2	-	36	3629	c.3397_splice	c.e36+1	p.H1133_splice	ATP8A1_uc003gwq.2_Splice_Site_p.H359_splice|ATP8A1_uc003gws.2_Splice_Site_p.H1118_splice	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),						ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	CAAATACTCACGGAGCAGATT	0.388													24	82					0	0	0	0	T	42416643	T	T	42416643	5	4	201	1	0	0	0	0	0	0	1	0	1194	550	19	1	104	1	ATP8A1	4	42416643	Splice_Site	SNP	C	TCGA-CV-6942-01A-21D-2012-08	31015697	42416643	148737633	75	36854											
LRRC66	339977	broad.mit.edu	37	chr4	52860807	52860807	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcagatctatcagtgtcaGaggcattttccagatgagtc	10	12	9	10	0	4	4	3	1	1	3	6	4	5	4	2	1	0	1	2	1	1	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr4:52860807G>C	uc003gzi.2	-	4	2394	c.2381C>G	c.(2380-2382)TCT>TGT	p.S794C		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	794						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						ATCAGTGTCAGAGGCATTTTC	0.473													4	32					0	0	0	0	C	52860807	C	C	52860807	3	2	201	1	0	0	0	0	1	0	0	0	9068	942	33	2	265	2	LRRC66	4	52860807	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	10444164	52860807	138293469	76	36855											
WDFY3	23001	broad.mit.edu	37	chr4	85701392	85701392	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caccaggcccaggatggctgCagctccaccaacgtactgca	10	5	10	16	1	0	0	0	0	0	0	1	1	1	1	4	3	5	5	4	3	2	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr4:85701392C>A	uc003hpd.2	-	26	4642	c.4234G>T	c.(4234-4236)GCA>TCA	p.A1412S		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1412						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGGATGGCTGCAGCTCCACCA	0.478													29	61					2.47511e-08	3.8195e-08	1	0	A	85701392	A	A	85701392	3	1	201	1	0	0	0	0	1	0	0	0	17338	710	25	4	6518	4	WDFY3	4	85701392	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	32840585	85701392	105452884	77	36856											
TBC1D9	23158	broad.mit.edu	37	chr4	141543569	141543569	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcagtgccgccgtgcccTggccgctccgcaccaggacc	4	4	15	18	4	0	0	0	0	0	0	1	1	1	1	7	4	2	3	7	4	0	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr4:141543569T>A	uc010ioj.2	-	21	3853	c.3581A>T	c.(3580-3582)CAG>CTG	p.Q1194L		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	1194						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CGCCGTGCCCTGGCCGCTCCG	0.667													6	32					0	0	0	0	A	141543569	A	A	141543569	3	1	201	1	0	0	0	0	1	0	0	0	15693	1580	55	5	223	5	TBC1D9	4	141543569	Missense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08	55842177	141543569	49610707	78	36857											
LRBA	987	broad.mit.edu	37	chr4	151271210	151271210	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcataggtcaagtaatagaaCacattgagggctcggacagc	14	8	11	8	1	2	2	2	1	0	1	3	3	2	3	0	3	2	2	0	3	5	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr4:151271210C>G	uc010ipj.2	-	49	7803	c.7329G>C	c.(7327-7329)GTG>GTC	p.V2443V	LRBA_uc010ipi.2_Intron|LRBA_uc003ils.3_Silent_p.V333V|LRBA_uc003ilt.3_Silent_p.V1091V|LRBA_uc003ilu.3_Silent_p.V2432V	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2443	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					AGTAATAGAACACATTGAGGG	0.413													8	34					0	0	0	0	G	151271210	G	G	151271210	2	3	201	1	0	0	0	0	0	0	0	1	8981	465	17	4		4	LRBA	4	151271210	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	9727641	151271210	39883066	79	36858											
ACCN5	51802	broad.mit.edu	37	chr4	156764841	156764841	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgagtatttaccttcacttGgcggatggttacccttgcgt	6	15	10	10	3	1	0	1	0	0	0	2	2	1	1	2	3	3	2	2	3	3	7			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr4:156764841G>T	uc003ipe.1	-	5	900	c.853C>A	c.(853-855)CAA>AAA	p.Q285K		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	285	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		ACCTTCACTTGGCGGATGGTT	0.443													19	71					1.37878e-21	2.28377e-21	1	0	T	156764841	T	T	156764841	3	4	201	1	0	0	0	0	1	0	0	0	132	1357	47	4	688	4	ACCN5	4	156764841	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	5493631	156764841	34389435	80	36859											
SORBS2	8470	broad.mit.edu	37	chr4	186545417	186545417	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcgtcgtttaggagatcgTcacagctccgggatttgatt	8	13	12	8	4	1	2	1	1	0	1	5	4	2	3	1	2	1	2	1	2	1	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr4:186545417T>C	uc003iyl.2	-	13	2012	c.1154A>G	c.(1153-1155)GAC>GGC	p.D385G	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.D485G|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.D289G|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.D499G|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	385						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TAGGAGATCGTCACAGCTCCG	0.532													12	36					0	0	0	0	C	186545417	C	C	186545417	3	2	201	1	0	0	0	0	1	0	0	0	14992	1667	58	5	2184	5	SORBS2	4	186545417	Missense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08	29780576	186545417	4608859	81	36860											
FAT1	2195	broad.mit.edu	37	chr4	187541705	187541721	+	Frame_Shift_Del	DEL	AAAGGCTCATTGATTGG	-	-																															ggttgaggatgtgataaaacAaaggctcattgattggattc																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr4:187541705_187541721delAAAGGCTCATTGATTGG	uc003izf.2	-	10	6207_6223	c.6019_6035delCCAATCAATGAGCCTTT	c.(6019-6036)CCAATCAATGAGCCTTTGfs	p.P2007fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2007_2012	Extracellular (Potential).|Cadherin 18.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTGATAAAACAAAGGCTCATTGATTGGATTCCCAATA	0.465										HNSCC(5;0.00058)			---	---	---								-	187541721	-	-	187541705	7	5	201	1	0	1	0	1	0	0	0	0	5721	131	5	0	7803	0	FAT1	4	187541705	Frame_Shift_Del	DEL	AAAGGCTCATTGATTGG	TCGA-CV-6942-01A-21D-2012-08	996288	187541705	3612571	82	36861											
SKIV2L2	23517	broad.mit.edu	37	chr5	54637510	54637510	+	Frame_Shift_Del	DEL	T	-	-																															tttttacttttttctttagaTtttgagaagtatgctttaca																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:54637510delT	uc003jpy.3	+	7	958	c.692delT	c.(691-693)ATTfs	p.I231fs	SKIV2L2_uc011cqi.1_Frame_Shift_Del_p.I130fs	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	231	Helicase ATP-binding.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TTTCTTTAGATTTTGAGAAGT	0.294													---	---	---								-	54637510	-	-	54637510	7	5	201	1	0	1	0	1	0	0	0	0	14425	1507	52	0	718	0	SKIV2L2	5	54637510	Frame_Shift_Del	DEL	T	TCGA-CV-6942-01A-21D-2012-08		54637510	126277750	83	36862											
MAP3K1	4214	broad.mit.edu	37	chr5	56152466	56152466	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaactctcaaagggttgcaCaagatggatgatcgtccaga	14	8	11	8	1	1	3	1	1	1	2	4	5	2	4	1	2	2	2	1	2	3	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:56152466C>T	uc003jqw.3	+	2	1023	c.522C>T	c.(520-522)CAC>CAT	p.H174H		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	174					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		AAGGGTTGCACAAGATGGATG	0.403													9	62					0	0	0	0	T	56152466	T	T	56152466	2	4	201	1	0	0	0	0	0	0	0	1	9296	477	17	4		4	MAP3K1	5	56152466	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1514956	56152466	124762794	84	36863											
MAST4	375449	broad.mit.edu	37	chr5	66409957	66409957	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actacctattggaagcagcaGaaggccatgccaaagaagga	16	5	11	9	0	0	2	0	0	0	2	0	4	0	4	3	3	4	2	3	3	6	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:66409957G>C	uc003jut.1	+	11	1002	c.934G>C	c.(934-936)GAA>CAA	p.E312Q	MAST4_uc003jus.2_Missense_Mutation_p.E312Q|MAST4_uc003juu.1_Missense_Mutation_p.E322Q|MAST4_uc011cra.1_Missense_Mutation_p.E295Q|MAST4_uc003juv.2_Missense_Mutation_p.E307Q|MAST4_uc003juw.2_Missense_Mutation_p.E307Q	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	504						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GGAAGCAGCAGAAGGCCATGC	0.438													14	38					0	0	0	0	C	66409957	C	C	66409957	3	2	201	1	0	0	0	0	1	0	0	0	9380	943	33	2	1677	2	MAST4	5	66409957	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	10257491	66409957	114505303	85	36864											
FAM169A	26049	broad.mit.edu	37	chr5	74077286	74077286	+	Nonstop_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catccactttcttcttccttCaggtcagcttagctttcttc	5	18	4	14	0	5	0	2	0	3	0	8	0	7	0	2	1	2	2	2	1	1	7			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:74077286C>G	uc003kdm.2	-	13	2055	c.2012G>C	c.(2011-2013)TGA>TCA	p.*671S	FAM169A_uc010izm.2_Nonstop_Mutation_p.*611S|FAM169A_uc003kdl.2_Nonstop_Mutation_p.*489S	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	671											0						CTTCTTCCTTCAGGTCAGCTT	0.388													29	120					0	0	0	0	G	74077286	G	G	74077286	4	3	201	1	0	0	0	0	0	0	0	0	5515	837	29	2	4	2	FAM169A	5	74077286	Nonstop_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	7667329	74077286	106837974	86	36865											
COL4A3BP	10087	broad.mit.edu	37	chr5	74722220	74722220	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgaagaggtggatgttgcAgagtagccacttgctccaga	12	9	13	7	0	0	4	0	1	0	3	1	5	1	5	2	2	3	4	2	2	3	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:74722220A>T	uc011csu.1	-	4	854	c.432T>A	c.(430-432)TCT>TCA	p.S144S	COL4A3BP_uc003kds.2_Silent_p.S144S|COL4A3BP_uc003kdt.2_Silent_p.S272S|COL4A3BP_uc003kdu.2_Silent_p.S144S	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	144					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		TGGATGTTGCAGAGTAGCCAC	0.398													6	82					0	0	0	0	T	74722220	T	T	74722220	2	4	201	1	0	0	0	0	0	0	0	1	3707	175	7	5		5	COL4A3BP	5	74722220	Silent	SNP	A	TCGA-CV-6942-01A-21D-2012-08	644934	74722220	106193040	87	36866											
CATSPER3	347732	broad.mit.edu	37	chr5	134305780	134305780	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgcttgttcagacttcttGaggtaagcagacaaaatggg	12	10	11	8	1	2	3	1	1	1	2	2	3	2	3	1	2	1	4	1	2	3	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:134305780G>C	uc003lag.2	+	2	318	c.250G>C	c.(250-252)GAG>CAG	p.E84Q		NM_178019	NP_821138	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	84	Helical; Name=Segment S2; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CAGACTTCTTGAGGTAAGCAG	0.294													15	81					0	0	0	0	C	134305780	C	C	134305780	3	2	201	1	0	0	0	0	1	0	0	0	2701	1291	45	2	256	2	CATSPER3	5	134305780	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	59583560	134305780	46609480	88	36867											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139825539	139825539	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaattcaaagaaagtgctCtaacacttgcttgctacaaa	16	11	6	8	0	2	2	1	1	1	1	2	2	2	2	0	0	5	3	0	0	6	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:139825539C>G	uc003lfs.1	+	6	1250	c.1126C>G	c.(1126-1128)CTA>GTA	p.L376V	ANKHD1_uc003lfq.1_Missense_Mutation_p.L376V|ANKHD1_uc003lfr.2_Missense_Mutation_p.L376V|ANKHD1_uc003lfp.2_Missense_Mutation_p.L365V|ANKHD1_uc003lfo.2_Missense_Mutation_p.L376V|ANKHD1_uc010jfk.2_Missense_Mutation_p.L376V	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	376						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAAGTGCTCTAACACTTGC	0.348													7	21					0	0	0	0	G	139825539	G	G	139825539	3	3	201	1	0	0	0	0	1	0	0	0	629	912	32	2	1148	2	ANKHD1-EIF4EBP3	5	139825539	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	5519759	139825539	41089721	89	36868											
PCDHB4	56131	broad.mit.edu	37	chr5	140502282	140502282	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaatcctgatcatggacatCaatgacaatgctcctgagtt	12	11	8	10	1	2	3	2	3	0	0	4	5	4	4	2	1	1	2	2	1	3	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:140502282C>A	uc003lip.1	+	1	702	c.702C>A	c.(700-702)ATC>ATA	p.I234I		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	234	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCATGGACATCAATGACAATG	0.527													23	105					3.62473e-10	5.71695e-10	1	0	A	140502282	A	A	140502282	2	1	201	1	0	0	0	0	0	0	0	1	11598	816	29	2		2	PCDHB4	5	140502282	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	676743	140502282	40412978	90	36869											
PCDHGB5	56101	broad.mit.edu	37	chr5	140779967	140779967	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgcacatacaggaaagaCggagtttaatttcctaaaat	15	12	8	6	1	0	1	0	0	0	1	1	3	1	3	1	2	2	3	1	2	5	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:140779967C>T	uc003lkf.1	+	1	2273	c.2273C>T	c.(2272-2274)ACG>ATG	p.T758M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.T758M|PCDHGA9_uc011dax.1_5'Flank|PCDHGA9_uc003lkh.1_5'Flank	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	758	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGGAAAGACGGAGTTTAAT	0.448													66	267					0	0	0	0	T	140779967	T	T	140779967	3	4	201	1	0	0	0	0	1	0	0	0	11620	536	19	1	2275	1	PCDHGB5	5	140779967	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	277685	140779967	40135293	91	36870											
PCDH1	5097	broad.mit.edu	37	chr5	141243981	141243981	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcattctcccccttgtctcCatcaatgacagtcaccatgc	8	11	6	16	0	4	1	2	1	2	0	6	1	4	1	4	1	1	1	4	1	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:141243981C>T	uc003llq.2	-	3	2032	c.1915G>A	c.(1915-1917)GGA>AGA	p.G639R	PCDH1_uc003llp.2_Missense_Mutation_p.G639R|PCDH1_uc011dbf.1_Missense_Mutation_p.G617R	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	639	Extracellular (Potential).|Cadherin 6.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CCCTTGTCTCCATCAATGACA	0.517													16	62					0	0	0	0	T	141243981	T	T	141243981	3	4	201	1	0	0	0	0	1	0	0	0	11560	603	21	4	1894	4	PCDH1	5	141243981	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	464014	141243981	39671279	92	36871											
ODZ2	57451	broad.mit.edu	37	chr5	167419991	167419991	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggggagcacacccttgttCagcagctcttccccgggata	7	9	11	14	2	2	0	1	0	1	0	4	2	3	2	3	3	3	4	3	3	1	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:167419991C>T	uc010jjd.2	+	5	990	c.990C>T	c.(988-990)TTC>TTT	p.F330F	ODZ2_uc003lzq.2_Silent_p.F209F|ODZ2_uc003lzr.3_Silent_p.F139F	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CACCCTTGTTCAGCAGCTCTT	0.567													22	52					0	0	0	0	T	167419991	T	T	167419991	2	4	201	1	0	0	0	0	0	0	0	1	10889	825	29	2		2	ODZ2	5	167419991	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	26176010	167419991	13495269	93	36872											
NSD1	64324	broad.mit.edu	37	chr5	176721768	176721768	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acctaactcctcgccagaagGagcgggcagcttcacctcat	10	7	9	15	2	2	1	2	0	0	1	4	2	3	2	4	2	3	2	4	2	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr5:176721768G>C	uc003mfr.3	+	23	7537	c.7399G>C	c.(7399-7401)GAG>CAG	p.E2467Q	NSD1_uc003mft.3_Missense_Mutation_p.E2198Q|NSD1_uc011dfx.1_Missense_Mutation_p.E2115Q	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2467					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCGCCAGAAGGAGCGGGCAGC	0.502			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			13	60					0	0	0	0	C	176721768	C	C	176721768	3	2	201	1	0	0	0	0	1	0	0	0	10723	1175	41	2	7485	2	NSD1	5	176721768	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	9301777	176721768	4193492	94	36873											
JARID2	3720	broad.mit.edu	37	chr6	15508627	15508627	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttctacctcatgctggtctCgagaccaaaatcaccttcca	10	12	5	14	1	4	1	2	0	2	1	6	2	5	1	4	1	2	1	4	1	3	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:15508627C>G	uc003nbj.2	+	12	3032	c.2788C>G	c.(2788-2790)CGA>GGA	p.R930G	JARID2_uc011div.1_Missense_Mutation_p.R758G|JARID2_uc011diw.1_Missense_Mutation_p.R892G	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	930	JmjC.				central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				ATGCTGGTCTCGAGACCAAAA	0.463													12	47					0	0	0	0	G	15508627	G	G	15508627	3	3	201	1	0	0	0	0	1	0	0	0	7984	876	31	3	2834	3	JARID2	6	15508627	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08		15508627	155606440	95	36874											
KIAA0319	9856	broad.mit.edu	37	chr6	24596166	24596166	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttttctttctccaacacctCtcctgaagatggagtagtcg	8	14	7	12	1	3	2	0	1	3	1	6	3	3	3	3	1	1	1	3	1	3	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:24596166C>G	uc011djo.1	-	3	973	c.736G>C	c.(736-738)GAG>CAG	p.E246Q	KIAA0319_uc011djp.1_Missense_Mutation_p.E201Q|KIAA0319_uc003neh.1_Missense_Mutation_p.E246Q|KIAA0319_uc011djq.1_Missense_Mutation_p.E237Q|KIAA0319_uc011djr.1_Missense_Mutation_p.E246Q	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	246	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						TCCAACACCTCTCCTGAAGAT	0.527													20	91					0	0	0	0	G	24596166	G	G	24596166	3	3	201	1	0	0	0	0	1	0	0	0	8207	922	32	2	2558	2	KIAA0319	6	24596166	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	9087539	24596166	146518901	96	36875											
HIST1H2BH	8345	broad.mit.edu	37	chr6	26252092	26252092	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cctttgtcaacgatatcttcGagcgcatcgccggcgaggct	7	10	11	13	6	2	0	1	0	1	0	4	3	2	0	2	2	2	2	2	2	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:26252092G>C	uc003nhh.2	+	1	214	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	HIST1H3F_uc003nhg.1_5'Flank	NM_003524	NP_003515	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	72					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)	3						CGATATCTTCGAGCGCATCGC	0.577													22	142					0	0	0	0	C	26252092	C	C	26252092	3	2	201	1	0	0	0	0	1	0	0	0	7186	1059	37	3	216	3	HIST1H2BH	6	26252092	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1655926	26252092	144862975	97	36876											
SCAND3	114821	broad.mit.edu	37	chr6	28554275	28554275	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccactgacggcaaagttcccGcagttgactcagagcctccc	9	7	9	16	2	1	3	1	2	0	1	3	3	3	3	4	1	1	4	4	1	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:28554275G>A	uc003nlo.2	-	1	838	c.220C>T	c.(220-222)CGG>TGG	p.R74W	uc003nlp.1_5'Flank	NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	74	SCAN box.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CAAAGTTCCCGCAGTTGACTC	0.542													17	77					0	0	0	0	A	28554275	A	A	28554275	3	1	201	1	0	0	0	0	1	0	0	0	13941	1086	38	1	3773	1	SCAND3	6	28554275	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	2302183	28554275	142560792	98	36877											
OR14J1	442191	broad.mit.edu	37	chr6	29274829	29274829	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgatgtcttatgacaggtaCgcagcaatctgtcaaccact	11	11	9	10	1	3	2	1	2	2	0	3	2	3	2	1	1	3	3	1	1	4	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:29274829C>T	uc011dln.1	+	1	363	c.363C>T	c.(361-363)TAC>TAT	p.Y121Y		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATGACAGGTACGCAGCAATCT	0.478													29	87					0	0	0	0	T	29274829	T	T	29274829	2	4	201	1	0	0	0	0	0	0	0	1	11002	547	19	1		1	OR14J1	6	29274829	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	720554	29274829	141840238	99	36878											
SKIV2L	6499	broad.mit.edu	37	chr6	31934521	31934521	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcagtcccagttccgcctCacgtacactatgatcctcaa	9	10	6	16	2	2	1	2	1	0	0	5	1	5	1	4	0	2	3	4	0	3	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:31934521C>T	uc003nyn.1	+	19	2627	c.2238C>T	c.(2236-2238)CTC>CTT	p.L746L	SKIV2L_uc011dou.1_Silent_p.L588L|SKIV2L_uc011dov.1_Silent_p.L553L	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	746	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						AGTTCCGCCTCACGTACACTA	0.567													23	124					0	0	0	0	T	31934521	T	T	31934521	2	4	201	1	0	0	0	0	0	0	0	1	14424	813	29	2		2	SKIV2L	6	31934521	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	2659692	31934521	139180546	100	36879											
SKIV2L	6499	broad.mit.edu	37	chr6	31934894	31934894	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacagctggggggaggaactGacagagacccagcacatgat	13	5	14	9	0	0	3	0	2	0	1	0	6	0	5	1	4	4	2	1	4	2	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:31934894G>C	uc003nyn.1	+	20	2843	c.2454G>C	c.(2452-2454)CTG>CTC	p.L818L	SKIV2L_uc011dou.1_Silent_p.L660L|SKIV2L_uc011dov.1_Silent_p.L625L	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	818						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						GGGAGGAACTGACAGAGACCC	0.537													16	77					0	0	0	0	C	31934894	C	C	31934894	2	2	201	1	0	0	0	0	0	0	0	1	14424	1277	45	2		2	SKIV2L	6	31934894	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	373	31934894	139180173	101	36880											
SLC26A8	116369	broad.mit.edu	37	chr6	35980126	35980126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaagattgtaagcacgcatCgtaggaacctgtgccatgag	13	8	12	8	2	0	2	0	1	0	1	1	4	0	3	2	1	3	4	2	1	4	3	rs116146081	by1000genomes	TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:35980126C>T	uc003olm.2	-	3	323	c.212G>A	c.(211-213)CGA>CAA	p.R71Q	SLC26A8_uc003oln.2_Missense_Mutation_p.R71Q|SLC26A8_uc003oll.2_Missense_Mutation_p.R71Q	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	71	Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						AAGCACGCATCGTAGGAACCT	0.463													17	94					0	0	0	0	T	35980126	T	T	35980126	3	4	201	1	0	0	0	0	1	0	0	0	14587	884	31	1	2772	1	SLC26A8	6	35980126	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	4045232	35980126	135134941	102	36881											
GPR115	221393	broad.mit.edu	37	chr6	47678616	47678616	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcctttctgtggaaaaactCtttaaggtgatgcattcaca	12	13	8	8	0	3	1	1	1	2	0	3	2	3	2	1	2	3	1	1	2	3	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:47678616C>G	uc003oza.1	+	4	552	c.294C>G	c.(292-294)CTC>CTG	p.L98L	GPR115_uc003oyz.1_Silent_p.L155L|GPR115_uc003ozb.1_Silent_p.L96L	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	98	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						TGGAAAAACTCTTTAAGGTGA	0.373													9	39					0	0	0	0	G	47678616	G	G	47678616	2	3	201	1	0	0	0	0	0	0	0	1	6670	900	32	2		2	GPR115	6	47678616	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	11698490	47678616	123436451	103	36882											
RAB23	51715	broad.mit.edu	37	chr6	57075104	57075104	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttgcaatatcgctgaatCatacttgattttccaactgc	10	15	5	11	1	1	2	1	2	0	0	3	2	2	2	2	0	4	2	2	0	5	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:57075104C>A	uc003pds.2	-	2	281	c.75G>T	c.(73-75)ATG>ATT	p.M25I	RAB23_uc003pdt.2_Missense_Mutation_p.M25I|RAB23_uc010kac.2_Missense_Mutation_p.M25I|RAB23_uc010kad.2_RNA	NM_183227	NP_899050	Q9ULC3	RAB23_HUMAN	Ras-related protein Rab-23	25					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			skin(1)	1	Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ATCGCTGAATCATACTTGATT	0.378													21	79					7.45023e-12	1.20156e-11	1	0	A	57075104	A	A	57075104	3	1	201	1	0	0	0	0	1	0	0	0	12975	826	29	2	662	2	RAB23	6	57075104	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	9396488	57075104	114039963	104	36883											
AHI1	54806	broad.mit.edu	37	chr6	135787271	135787271	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaccttattctcaggagtttCcggtttcaggtcttgtgtag	7	16	10	8	1	3	0	2	0	2	0	5	1	4	1	2	3	1	3	2	3	3	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:135787271C>A	uc003qgi.2	-	7	814	c.430G>T	c.(430-432)GAA>TAA	p.E144*	AHI1_uc003qgh.2_Nonsense_Mutation_p.E144*|AHI1_uc003qgj.2_Nonsense_Mutation_p.E144*|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Nonsense_Mutation_p.E144*	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	144						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TCAGGAGTTTCCGGTTTCAGG	0.438													37	107					3.03874e-20	5.01392e-20	1	0	A	135787271	A	A	135787271	4	1	201	1	0	0	0	0	0	1	0	0	413	864	30	2	3309	2	AHI1	6	135787271	Nonsense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	78712167	135787271	35327796	105	36884											
SYNE1	23345	broad.mit.edu	37	chr6	152470722	152470722	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatcgctgcatccaagggctCactcttttctatcagctgtt	7	14	8	12	1	4	0	2	0	2	0	6	1	5	0	1	1	2	5	1	1	2	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr6:152470722C>T	uc010kiw.2	-	136	25134	c.24532G>A	c.(24532-24534)GAG>AAG	p.E8178K	SYNE1_uc010kiv.2_Missense_Mutation_p.E2702K|SYNE1_uc003qos.3_Missense_Mutation_p.E2702K|SYNE1_uc003qot.3_Missense_Mutation_p.E8107K|SYNE1_uc003qou.3_Missense_Mutation_p.E8178K|SYNE1_uc003qop.3_Missense_Mutation_p.E340K|SYNE1_uc011eez.1_Missense_Mutation_p.E380K|SYNE1_uc003qoq.3_Missense_Mutation_p.E380K|SYNE1_uc003qor.3_Missense_Mutation_p.E1078K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8178	Spectrin 30.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCCAAGGGCTCACTCTTTTCT	0.478										HNSCC(10;0.0054)			20	62					0	0	0	0	T	152470722	T	T	152470722	3	4	201	1	0	0	0	0	1	0	0	0	15511	835	29	2	1978	2	SYNE1	6	152470722	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	16683451	152470722	18644345	106	36885											
OSBPL3	26031	broad.mit.edu	37	chr7	24905839	24905839	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcgatacccactcatcaaaGacttcttctgacttgaccta	11	13	4	13	1	4	3	2	2	2	1	5	4	4	3	2	0	1	0	2	0	3	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:24905839G>A	uc003sxf.2	-	6	804	c.399C>T	c.(397-399)GTC>GTT	p.V133V	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Silent_p.V133V|OSBPL3_uc003sxh.2_Silent_p.V133V|OSBPL3_uc003sxi.2_Silent_p.V133V	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	133	PH.				lipid transport		lipid binding|protein binding			skin(1)	1						ACTCATCAAAGACTTCTTCTG	0.388													14	40					0	0	0	0	A	24905839	A	A	24905839	2	1	201	1	0	0	0	0	0	0	0	1	11333	929	33	2		2	OSBPL3	7	24905839	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08		24905839	134232824	107	36886											
SUN3	256979	broad.mit.edu	37	chr7	48068470	48068470	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcattgccactggcgctaccGctggcgtcttcagagcaacg	7	8	12	14	4	2	1	1	0	1	1	2	1	2	1	2	2	4	4	2	2	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:48068470G>A	uc003tof.2	-	2	163	c.66C>T	c.(64-66)AGC>AGT	p.S22S	SUN3_uc003tog.2_Silent_p.S22S|SUN3_uc011kcf.1_5'UTR	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	22						integral to membrane				central_nervous_system(1)	1						TGGCGCTACCGCTGGCGTCTT	0.473													25	87					0	0	0	0	A	48068470	A	A	48068470	2	1	201	1	0	0	0	0	0	0	0	1	15459	1078	38	1		1	SUN3	7	48068470	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	23162631	48068470	111070193	108	36887											
FZD9	8326	broad.mit.edu	37	chr7	72849297	72849297	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgctggtcttcctactgctCtactacttcggcatggccag	6	12	9	14	2	2	0	0	0	2	0	4	0	3	0	2	3	4	3	2	3	3	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:72849297C>G	uc003tyb.2	+	1	1189	c.960C>G	c.(958-960)CTC>CTG	p.L320L		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	320	Helical; Name=3; (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				TCCTACTGCTCTACTACTTCG	0.667													14	62					0	0	0	0	G	72849297	G	G	72849297	2	3	201	1	0	0	0	0	0	0	0	1	6171	900	32	2		2	FZD9	7	72849297	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	24780827	72849297	86289366	109	36888											
FZD9	8326	broad.mit.edu	37	chr7	72849453	72849453	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccgcgctcaagaccatcgtCatcctgaccctgcgcaaggt	8	7	9	17	4	2	2	2	1	0	1	4	2	3	2	4	1	1	2	4	1	2	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:72849453C>T	uc003tyb.2	+	1	1345	c.1116C>T	c.(1114-1116)GTC>GTT	p.V372V		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	372	Helical; Name=4; (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGACCATCGTCATCCTGACCC	0.662													24	42					0	0	0	0	T	72849453	T	T	72849453	2	4	201	1	0	0	0	0	0	0	0	1	6171	813	29	2		2	FZD9	7	72849453	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	156	72849453	86289210	110	36889											
PCLO	27445	broad.mit.edu	37	chr7	82763968	82763968	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggctgtgaaggggcaggggcTtgtttcattggggcccctgg	4	10	19	8	0	1	1	1	1	0	0	1	1	1	1	2	8	0	4	2	8	1	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:82763968T>C	uc003uhx.2	-	3	3187	c.2898A>G	c.(2896-2898)CAA>CAG	p.Q966Q	PCLO_uc003uhv.2_Silent_p.Q966Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	912	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGGCAGGGGCTTGTTTCATTG	0.507													9	41					0	0	0	0	C	82763968	C	C	82763968	2	2	201	1	0	0	0	0	0	0	0	1	11637	1606	56	5		5	PCLO	7	82763968	Silent	SNP	T	TCGA-CV-6942-01A-21D-2012-08	9914515	82763968	76374695	111	36890											
PCLO	27445	broad.mit.edu	37	chr7	82785588	82785588	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggactcctcccaggcaatttCtgctctgacctgaaagtgtc	8	11	9	13	0	2	2	0	2	2	0	5	3	4	3	3	2	1	2	3	2	2	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:82785588C>G	uc003uhx.2	-	2	658	c.369G>C	c.(367-369)CAG>CAC	p.Q123H	PCLO_uc003uhv.2_Missense_Mutation_p.Q123H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	123					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CAGGCAATTTCTGCTCTGACC	0.483													15	76					0	0	0	0	G	82785588	G	G	82785588	3	3	201	1	0	0	0	0	1	0	0	0	11637	912	32	2	15172	2	PCLO	7	82785588	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	21620	82785588	76353075	112	36891											
COL1A2	1278	broad.mit.edu	37	chr7	94057185	94057185	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttgagactcagccacccaGagtggagcagtggtaggtca	11	7	13	10	0	2	2	2	1	0	2	2	4	2	3	2	3	2	2	2	3	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:94057185G>C	uc003ung.1	+	49	3985	c.3514G>C	c.(3514-3516)GAG>CAG	p.E1172Q	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1172	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CAGCCACCCAGAGTGGAGCAG	0.468										HNSCC(75;0.22)			4	27					0	0	0	0	C	94057185	C	C	94057185	3	2	201	1	0	0	0	0	1	0	0	0	3693	943	33	2	3708	2	COL1A2	7	94057185	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	11271597	94057185	65081478	113	36892											
GAL3ST4	79690	broad.mit.edu	37	chr7	99757817	99757817	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttcgctagggcctctcggcGagcccggagctcggccacag	5	7	14	15	5	1	0	0	0	1	0	4	2	1	1	3	4	2	2	3	4	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:99757817G>A	uc003utt.2	-	3	2212	c.1195C>T	c.(1195-1197)CGC>TGC	p.R399C	C7orf43_uc010lgp.2_5'Flank|C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.R399C|GAL3ST4_uc010lgq.2_Missense_Mutation_p.R337C	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	399	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCTCTCGGCGAGCCCGGAGC	0.612													36	102					0	0	0	0	A	99757817	A	A	99757817	3	1	201	1	0	0	0	0	1	0	0	0	6235	1058	37	1	269	1	GAL3ST4	7	99757817	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	5700632	99757817	59380846	114	36893											
CFTR	1080	broad.mit.edu	37	chr7	117149168	117149168	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttttttctggagatttaTgttctatggaatctttttat	8	23	7	3	0	3	1	0	0	3	1	3	3	3	2	0	2	0	2	0	2	4	10			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:117149168T>A	uc003vjd.2	+	3	377	c.245T>A	c.(244-246)ATG>AAG	p.M82K	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	82	Helical; Name=1; (Potential).|ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TGGAGATTTATGTTCTATGGA	0.318									Cystic_Fibrosis				22	103					0	0	0	0	A	117149168	A	A	117149168	3	1	201	1	0	0	0	0	1	0	0	0	3309	1464	51	5	255	5	CFTR	7	117149168	Missense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08	17391351	117149168	41989495	115	36894											
FEZF1	389549	broad.mit.edu	37	chr7	121943869	121943869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagggtatttctccaccGccgggaccaccagtttattc	9	10	9	13	2	1	1	0	0	1	1	3	2	1	2	5	2	0	2	5	2	3	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:121943869G>A	uc003vkd.2	-	1	697	c.623C>T	c.(622-624)GCG>GTG	p.A208V	FEZF1_uc003vkc.2_Missense_Mutation_p.A158V|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	208					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						TTTCTCCACCGCCGGGACCAC	0.527													17	54					0	0	0	0	A	121943869	A	A	121943869	3	1	201	1	0	0	0	0	1	0	0	0	5857	1087	38	1	820	1	FEZF1	7	121943869	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	4794701	121943869	37194794	116	36895											
IQUB	154865	broad.mit.edu	37	chr7	123097516	123097516	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttccagggggaccactccagGgatttattccatctgaccat	9	11	9	12	0	1	1	0	1	1	0	4	3	4	3	5	3	0	0	5	3	1	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:123097516G>T	uc003vkn.2	-	12	2689	c.2112C>A	c.(2110-2112)TCC>TCA	p.S704S	IQUB_uc011kny.1_Silent_p.S37S|IQUB_uc003vko.2_Silent_p.S704S|IQUB_uc010lkt.2_RNA	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	704										ovary(3)|large_intestine(1)	4						ACCACTCCAGGGATTTATTCC	0.453													24	112					8.24728e-16	1.35041e-15	1	0	T	123097516	T	T	123097516	2	4	201	1	0	0	0	0	0	0	0	1	7859	1219	43	4		4	IQUB	7	123097516	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1153647	123097516	36041147	117	36896											
TPK1	27010	broad.mit.edu	37	chr7	144380027	144380027	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctctctccttcggtgatatCatataagcggttggcacctc	7	14	8	12	2	3	1	1	1	2	0	7	1	3	1	2	3	1	2	2	3	3	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:144380027C>G	uc003weq.2	-	4	263	c.160G>C	c.(160-162)GAT>CAT	p.D54H	TPK1_uc003weo.2_Missense_Mutation_p.M8I|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Missense_Mutation_p.D54H|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	54					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	TCGGTGATATCATATAAGCGG	0.378													42	142					0	0	0	0	G	144380027	G	G	144380027	3	3	201	1	0	0	0	0	1	0	0	0	16471	826	29	2	595	2	TPK1	7	144380027	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	21282511	144380027	14758636	118	36897											
GIMAP5	55340	broad.mit.edu	37	chr7	150439312	150439312	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaacaccaccggcattgAggattatcctagtgggcaaa	12	8	10	11	1	0	1	0	1	0	0	1	2	1	2	3	3	2	3	3	3	4	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:150439312A>G	uc003whr.1	+	3	437	c.85A>G	c.(85-87)AGG>GGG	p.R29G	GIMAP5_uc010lpu.2_5'UTR	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	29	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACCGGCATTGAGGATTATCCT	0.468													3	60					0	0	0	0	G	150439312	G	G	150439312	3	3	201	1	0	0	0	0	1	0	0	0	6419	295	11	5	91	5	GIMAP5	7	150439312	Missense_Mutation	SNP	A	TCGA-CV-6942-01A-21D-2012-08	6059285	150439312	8699351	119	36898											
MLL3	58508	broad.mit.edu	37	chr7	152012253	152012253	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctttgttttcgtggtgctGagttttgcattttctcatag	4	21	9	7	1	2	1	1	1	2	0	4	1	2	1	0	1	2	4	0	1	1	8			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr7:152012253G>C	uc003wla.2	-	4	779	c.560C>G	c.(559-561)TCA>TGA	p.S187*		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	187					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCGTGGTGCTGAGTTTTGCAT	0.353			N		medulloblastoma								23	88					0	0	0	0	C	152012253	C	C	152012253	4	2	201	1	0	0	0	0	0	1	0	0	9675	1294	45	2	14399	2	MLL3	7	152012253	Nonsense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1572941	152012253	7126410	120	36899											
PXDNL	137902	broad.mit.edu	37	chr8	52252221	52252221	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgatggtttcctgaatttccGctgcaaacgtgctgaaatct	9	14	9	9	2	1	3	0	3	1	0	3	3	3	3	2	1	3	4	2	1	3	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr8:52252221G>C	uc003xqu.3	-	21	4210	c.4109C>G	c.(4108-4110)GCG>GGG	p.A1370G	PXDNL_uc003xqt.3_Intron	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1370					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTGAATTTCCGCTGCAAACGT	0.368													21	108					0	0	0	0	C	52252221	C	C	52252221	3	2	201	1	0	0	0	0	1	0	0	0	12913	1087	38	3	294	3	PXDNL	8	52252221	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08		52252221	94111801	121	36900											
SLC7A13	157724	broad.mit.edu	37	chr8	87230021	87230021	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggcataatccatgctaatGagggaaaagctcgatcagcc	15	7	10	9	1	1	1	1	1	0	0	3	3	2	2	2	2	3	3	2	2	5	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr8:87230021G>A	uc003ydq.1	-	3	955	c.857C>T	c.(856-858)TCA>TTA	p.S286L	SLC7A13_uc003ydr.1_Missense_Mutation_p.S277L	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	286	Extracellular (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						CCATGCTAATGAGGGAAAAGC	0.333													27	73					0	0	0	0	A	87230021	A	A	87230021	3	1	201	1	0	0	0	0	1	0	0	0	14759	1294	45	2	563	2	SLC7A13	8	87230021	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	34977800	87230021	59134001	122	36901											
CDH17	1015	broad.mit.edu	37	chr8	95172204	95172204	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaatgggctatttaccttttTaattatgacatatccggtgt	11	17	7	6	1	0	1	0	1	0	0	1	1	1	1	2	2	1	1	2	2	6	8			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr8:95172204T>A	uc003ygh.2	-	12	1671	c.1546A>T	c.(1546-1548)AAA>TAA	p.K516*	CDH17_uc011lgo.1_Nonsense_Mutation_p.K302*|CDH17_uc011lgp.1_Nonsense_Mutation_p.K516*	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	516	Extracellular (Potential).|Cadherin 5.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TTTACCTTTTTAATTATGACA	0.378													8	81					0	0	0	0	A	95172204	A	A	95172204	4	1	201	1	0	0	0	0	0	1	0	0	3117	1763	61	5	980	5	CDH17	8	95172204	Nonsense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08	7942183	95172204	51191818	123	36902											
MTBP	27085	broad.mit.edu	37	chr8	121473491	121473491	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatgtcggatattgaatttGagttgtatcctttcatttac	10	19	7	5	1	1	2	1	2	0	0	3	3	2	3	1	1	1	2	1	1	5	9			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr8:121473491G>C	uc003ypc.1	+	9	1018	c.973G>C	c.(973-975)GAG>CAG	p.E325Q	MTBP_uc011lie.1_RNA	NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	325					cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			TATTGAATTTGAGTTGTATCC	0.323													13	42					0	0	0	0	C	121473491	C	C	121473491	3	2	201	1	0	0	0	0	1	0	0	0	9965	1291	45	2	1007	2	MTBP	8	121473491	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	26301287	121473491	24890531	124	36903											
PTPRD	5789	broad.mit.edu	37	chr9	8518241	8518241	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcataatccgagtagggacTtagtccagcgacactgtagc	11	10	10	10	2	1	0	1	0	0	0	3	3	3	1	2	1	2	2	2	1	4	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:8518241T>G	uc003zkk.2	-	20	1861	c.1150A>C	c.(1150-1152)AGT>CGT	p.S384R	PTPRD_uc003zkp.2_Missense_Mutation_p.S384R|PTPRD_uc003zkq.2_Missense_Mutation_p.S384R|PTPRD_uc003zkr.2_Missense_Mutation_p.S378R|PTPRD_uc003zks.2_Missense_Mutation_p.S374R|PTPRD_uc003zkl.2_Missense_Mutation_p.S384R|PTPRD_uc003zkm.2_Missense_Mutation_p.S371R|PTPRD_uc003zkn.2_Missense_Mutation_p.S384R|PTPRD_uc003zko.2_Missense_Mutation_p.S381R	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	384	Fibronectin type-III 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAGTAGGGACTTAGTCCAGCG	0.463										TSP Lung(15;0.13)			24	159					0	0	0	0	G	8518241	G	G	8518241	3	3	201	1	0	0	0	0	1	0	0	0	12864	1609	56	5	4760	5	PTPRD	9	8518241	Missense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08		8518241	132695190	125	36904											
CDKN2A	1029	broad.mit.edu	37	chr9	21974696	21974696	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctggatcggcctccgaccgTaactattcggtgcgttgggc	5	10	13	13	5	0	0	0	0	0	0	3	2	1	1	4	4	2	2	4	4	2	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:21974696T>C	uc003zpk.2	-	1	343	c.131A>G	c.(130-132)TAC>TGC	p.Y44C	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Missense_Mutation_p.Y44C|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	44	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(25)|p.Y44*(3)|p.Y44fs*1(1)|p.Y44fs*76(1)|p.V28_V51del(1)|p.Y44S(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCTCCGACCGTAACTATTCGG	0.687		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			38	135					0	0	0	0	C	21974696	C	C	21974696	3	2	201	1	0	0	0	0	1	0	0	0	3176	1638	57	5	552	5	CDKN2A	9	21974696	Missense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08	13456455	21974696	119238735	126	36905											
TAF1L	138474	broad.mit.edu	37	chr9	32630264	32630264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcccagcatcttcctcatCatcttctccttcagatataa	10	14	2	15	0	6	1	3	0	3	1	9	1	8	1	3	0	1	1	3	0	2	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:32630264C>T	uc003zrg.1	-	1	5404	c.5314G>A	c.(5314-5316)GAT>AAT	p.D1772N		NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1772					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCTTCCTCATCATCTTCTCCT	0.463													25	103					0	0	0	0	T	32630264	T	T	32630264	3	4	201	1	0	0	0	0	1	0	0	0	15589	826	29	2	170	2	TAF1L	9	32630264	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	10655568	32630264	108583167	127	36906											
FAM75A6	389730	broad.mit.edu	37	chr9	43627785	43627785	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgggtggcgggaaagaGgatcttgctggactgatgag	8	9	19	5	1	1	3	0	2	1	1	1	6	1	6	0	6	1	1	0	6	1	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:43627785G>T	uc011lrb.1	-	4	931	c.902C>A	c.(901-903)CCT>CAT	p.P301H		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	301						integral to membrane					0						GCGGGAAAGAGGATCTTGCTG	0.547													6	149					3.59834e-05	5.30476e-05	1	0	T	43627785	T	T	43627785	3	4	201	1	0	0	0	0	1	0	0	0	5654	1000	35	4	3133	4	FAM75A6	9	43627785	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	10997521	43627785	97585646	128	36907											
DAPK1	1612	broad.mit.edu	37	chr9	90296352	90296352	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gactcttcatccagcagctcCgacccacacagaacctgcag	11	6	7	17	1	2	1	1	0	1	1	4	3	4	1	4	0	4	3	4	0	1	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:90296352C>T	uc004apc.2	+	20	2173	c.2035C>T	c.(2035-2037)CGA>TGA	p.R679*	DAPK1_uc004apd.2_Nonsense_Mutation_p.R679*|DAPK1_uc011ltg.1_Nonsense_Mutation_p.R679*|DAPK1_uc011lth.1_Nonsense_Mutation_p.R416*|DAPK1_uc004apf.1_Nonsense_Mutation_p.R233*	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	679					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CCAGCAGCTCCGACCCACACA	0.502									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				32	136					0	0	0	0	T	90296352	T	T	90296352	4	4	201	1	0	0	0	0	0	1	0	0	4252	644	23	1	2109	1	DAPK1	9	90296352	Nonsense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	46668567	90296352	50917079	129	36908											
SHC3	53358	broad.mit.edu	37	chr9	91653163	91653163	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggctgccttgcttaacacGggccccaagggctggttctt	6	10	13	12	1	1	0	0	0	1	0	1	1	1	0	3	4	3	4	3	4	2	4	rs146503115		TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:91653163G>T	uc004aqg.2	-	11	1708	c.1401C>A	c.(1399-1401)CCC>CCA	p.P467P		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	467	CH1.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						TGCTTAACACGGGCCCCAAGG	0.502													19	69					2.4624e-09	3.82742e-09	1	0	T	91653163	T	T	91653163	2	4	201	1	0	0	0	0	0	0	0	1	14337	1103	39	3		3	SHC3	9	91653163	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1356811	91653163	49560268	130	36909											
DFNB31	25861	broad.mit.edu	37	chr9	117187294	117187294	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tattccttctgttgtgagatCgccaagaaacctgtggggaa	10	12	11	8	1	1	2	0	1	1	2	3	4	2	3	3	2	1	1	3	2	4	4	rs138164522		TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:117187294C>T	uc004biz.3	-	5	1826	c.1177G>A	c.(1177-1179)GAT>AAT	p.D393N	DFNB31_uc004bix.2_Missense_Mutation_p.D42N|DFNB31_uc004biy.3_Missense_Mutation_p.D10N|DFNB31_uc004bja.3_Missense_Mutation_p.D393N	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	393					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						GTTGTGAGATCGCCAAGAAAC	0.537													30	90					0	0	0	0	T	117187294	T	T	117187294	3	4	201	1	0	0	0	0	1	0	0	0	4477	884	31	1	1578	1	DFNB31	9	117187294	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	25534131	117187294	24026137	131	36910											
ODF2	4957	broad.mit.edu	37	chr9	131254985	131254985	+	Missense_Mutation	SNP	G	A	A																															gttgttggtccctaggtgatGaagaccagattggaggctga																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:131254985G>A	uc011mbd.1	+	16	1964	c.1653G>A	c.(1651-1653)ATG>ATA	p.M551I	ODF2_uc011maz.1_Missense_Mutation_p.M551I|ODF2_uc011mbb.1_Missense_Mutation_p.M485I|ODF2_uc011mbc.1_Missense_Mutation_p.M470I|ODF2_uc004bva.2_Missense_Mutation_p.M504I|ODF2_uc004bvb.2_Missense_Mutation_p.M527I|ODF2_uc011mbe.1_Missense_Mutation_p.M546I|ODF2_uc004bvc.2_Missense_Mutation_p.M527I|ODF2_uc011mbf.1_Missense_Mutation_p.M532I|ODF2_uc004bvd.3_Missense_Mutation_p.M551I|ODF2_uc004bve.2_Missense_Mutation_p.M532I	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	551	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						CCTAGGTGATGAAGACCAGAT	0.483													6	31					0	0	0	0	A	131254985	A	A	131254985	3	1	201	1	0	0	0	0	1	0	0	0	10881	1290	45	2	1766	2	ODF2	9	131254985	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	14067691	131254985	9958446	132	36911	70	2									
ODF2	4957	broad.mit.edu	37	chr9	131254993	131254993	+	Missense_Mutation	SNP	G	A	A																															tccctaggtgatgaagaccaGattggaggctgatgaagtag																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:131254993G>A	uc011mbd.1	+	16	1972	c.1661G>A	c.(1660-1662)AGA>AAA	p.R554K	ODF2_uc011maz.1_Missense_Mutation_p.R554K|ODF2_uc011mbb.1_Missense_Mutation_p.R488K|ODF2_uc011mbc.1_Missense_Mutation_p.R473K|ODF2_uc004bva.2_Missense_Mutation_p.R507K|ODF2_uc004bvb.2_Missense_Mutation_p.R530K|ODF2_uc011mbe.1_Missense_Mutation_p.R549K|ODF2_uc004bvc.2_Missense_Mutation_p.R530K|ODF2_uc011mbf.1_Missense_Mutation_p.R535K|ODF2_uc004bvd.3_Missense_Mutation_p.R554K|ODF2_uc004bve.2_Missense_Mutation_p.R535K	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	554	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						ATGAAGACCAGATTGGAGGCT	0.473													6	29					0	0	0	0	A	131254993	A	A	131254993	3	1	201	1	0	0	0	0	1	0	0	0	10881	942	33	2	1774	2	ODF2	9	131254993	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	8	131254993	9958438	133	36912	70	2									
LAMC3	10319	broad.mit.edu	37	chr9	133967144	133967145	+	Missense_Mutation	DNP	CC	AA	AA																															ctggaggccattctgcacagCctgcccgagaactgtgccag																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:133967144_133967145CC>AA	uc004caa.1	+	28	4796_4797	c.4698_4699CC>AA	c.(4696-4701)AGCCTG>AGAATG	p.1566_1567SL>RM	LAMC3_uc010mze.1_Missense_Mutation_p.254_255SL>RM	NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1566_1567	Domain II and I.|Potential.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TTCTGCACAGCCTGCCCGAGAA	0.634													11	27					0	0	0	0	AA	133967145	AA	AA	133967144	3	1	201	1	0	0	0	0	1	0	0	0	8656	738	26	4	4808	4	LAMC3	9	133967144	Missense_Mutation	DNP	CC	TCGA-CV-6942-01A-21D-2012-08	2712151	133967144	7246287	134	36913											
C9orf171	389799	broad.mit.edu	37	chr9	135413023	135413023	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttgatctgctgcagcaccGgtacctgcagctgtgggtac	6	11	12	12	1	1	1	0	1	1	0	1	1	1	1	2	2	7	7	2	2	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:135413023G>T	uc004cbn.2	+	5	716	c.668G>T	c.(667-669)CGG>CTG	p.R223L	C9orf171_uc004cbo.2_Missense_Mutation_p.R187L	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	223										ovary(4)|large_intestine(1)	5						CTGCAGCACCGGTACCTGCAG	0.572													21	94					5.45024e-15	8.89032e-15	1	0	T	135413023	T	T	135413023	3	4	201	1	0	0	0	0	1	0	0	0	2482	1116	39	3	686	3	C9orf171	9	135413023	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1445879	135413023	5800408	135	36914											
KIAA0649	9858	broad.mit.edu	37	chr9	138379081	138379081	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgaagggcttcgaggcacaGagagcgcaggagcacagggc	11	2	17	11	3	0	1	0	0	0	1	1	5	0	2	1	4	2	4	1	4	1	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:138379081G>C	uc004cfr.1	+	4	3274	c.2725G>C	c.(2725-2727)GAG>CAG	p.E909Q		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	909						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		TCGAGGCACAGAGAGCGCAGG	0.706													17	85					0	0	0	0	C	138379081	C	C	138379081	3	2	201	1	0	0	0	0	1	0	0	0	8226	943	33	2	2727	2	KIAA0649	9	138379081	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	2966058	138379081	2834350	136	36915											
NOTCH1	4851	broad.mit.edu	37	chr9	139409118	139409118	+	Frame_Shift_Del	DEL	C	-	-																															ccccgttgtggcaggggttgCccgcacactcatcgatgttg																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr9:139409118delC	uc004chz.2	-	13	2051	c.2051delG	c.(2050-2052)GGCfs	p.G684fs	NOTCH1_uc004cia.1_5'Flank	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	684	Extracellular (Potential).|EGF-like 18; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCAGGGGTTGCCCGCACACTC	0.662			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								-	139409118	-	-	139409118	7	5	201	1	0	1	0	1	0	0	0	0	10601	739	26	0	5704	0	NOTCH1	9	139409118	Frame_Shift_Del	DEL	C	TCGA-CV-6942-01A-21D-2012-08	1030037	139409118	1804313	137	36916											
OR13A1	79290	broad.mit.edu	37	chr10	45799190	45799190	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgatggtcatcaggaagttCactatgccgtagaaagcatc	12	9	11	9	2	3	1	3	0	0	1	4	3	3	2	1	2	2	3	1	2	4	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr10:45799190C>T	uc001jcc.1	-	4	990	c.681G>A	c.(679-681)GTG>GTA	p.V227V	OR13A1_uc001jcd.1_Silent_p.V223V	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	227	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCAGGAAGTTCACTATGCCGT	0.552													14	83					0	0	0	0	T	45799190	T	T	45799190	2	4	201	1	0	0	0	0	0	0	0	1	10987	813	29	2		2	OR13A1	10	45799190	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08		45799190	89735557	138	36917											
CYP2C19	1557	broad.mit.edu	37	chr10	96541716	96541716	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgatggacatcaacaaccctCgggactttattgattgcttc	10	12	8	11	2	1	1	1	1	0	0	3	4	1	3	1	2	3	1	1	2	3	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr10:96541716C>G	uc010qnz.1	+	5	781	c.781C>G	c.(781-783)CGG>GGG	p.R261G	CYP2C19_uc009xus.1_Missense_Mutation_p.R126G|CYP2C19_uc010qny.1_Missense_Mutation_p.R239G	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	261					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CAACAACCCTCGGGACTTTAT	0.353													22	47					0	0	0	0	G	96541716	G	G	96541716	3	3	201	1	0	0	0	0	1	0	0	0	4183	875	31	3	799	3	CYP2C19	10	96541716	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	50742526	96541716	38993031	139	36918											
MGEA5	10724	broad.mit.edu	37	chr10	103563684	103563684	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgatcataatcattagcatGaatgttatcccagattactg	13	14	6	8	0	2	3	2	2	0	1	3	3	3	3	1	0	2	2	1	0	5	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr10:103563684G>C	uc001ktv.2	-	7	1287	c.844C>G	c.(844-846)CAT>GAT	p.H282D	MGEA5_uc010qqe.1_Missense_Mutation_p.H282D|MGEA5_uc009xws.2_Missense_Mutation_p.H282D|MGEA5_uc001ktw.2_Missense_Mutation_p.H282D|MGEA5_uc009xwt.2_Intron	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	282					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TCATTAGCATGAATGTTATCC	0.398													28	117					0	0	0	0	C	103563684	C	C	103563684	3	2	201	1	0	0	0	0	1	0	0	0	9608	1290	45	2	1946	2	MGEA5	10	103563684	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	7021968	103563684	31971063	140	36919											
CNNM2	54805	broad.mit.edu	37	chr10	104678683	104678683	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gccggacagcggcccccagcGatgcggcatccgcacctcag	7	3	13	18	5	1	0	1	0	0	0	2	2	2	1	5	3	3	2	5	3	0	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr10:104678683G>C	uc001kwm.2	+	1	570	c.446G>C	c.(445-447)CGA>CCA	p.R149P	CNNM2_uc001kwn.2_Missense_Mutation_p.R149P|CNNM2_uc001kwl.2_Missense_Mutation_p.R149P	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	149					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GGCCCCCAGCGATGCGGCATC	0.517													36	114					0	0	0	0	C	104678683	C	C	104678683	3	2	201	1	0	0	0	0	1	0	0	0	3628	1058	37	3	448	3	CNNM2	10	104678683	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1114999	104678683	30856064	141	36920											
MUC5B	727897	broad.mit.edu	37	chr11	1271681	1271681	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacagctaccagctttacagCcatcccctcctcctccctgg	7	9	5	20	0	0	0	0	0	0	0	4	0	4	0	7	1	5	2	7	1	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:1271681C>G	uc009ycr.1	+	51	15116	c.14990C>G	c.(14989-14991)GCC>GGC	p.A4997G	MUC5B_uc001ltb.2_Missense_Mutation_p.A4527G	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4524	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGCTTTACAGCCATCCCCTCC	0.627													41	71					0	0	0	0	G	1271681	G	G	1271681	3	3	201	1	0	0	0	0	1	0	0	0	10032	739	26	4	13702	4	MUC5B	11	1271681	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08		1271681	133734835	142	36921											
EIF3M	10480	broad.mit.edu	37	chr11	32615458	32615458	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattgctcggaagttacacaGaggacaatgcttcccaggct	12	9	10	10	1	0	1	0	0	0	1	2	3	1	3	1	3	3	4	1	3	4	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:32615458G>C	uc001mtu.2	+	6	623	c.580G>C	c.(580-582)GAG>CAG	p.E194Q	EIF3M_uc010ref.1_Missense_Mutation_p.E62Q	NM_006360	NP_006351	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3,	194						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)|breast(1)|skin(1)	3	Breast(20;0.109)					AAGTTACACAGAGGACAATGC	0.388													12	26					0	0	0	0	C	32615458	C	C	32615458	3	2	201	1	0	0	0	0	1	0	0	0	5047	943	33	2	602	2	EIF3M	11	32615458	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	31343777	32615458	102391058	143	36922											
EHF	26298	broad.mit.edu	37	chr11	34668200	34668200	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggacggcggggcagctcctCtacagcaacttgcagcatct	8	7	13	13	2	2	0	0	0	2	0	3	1	3	1	1	4	6	5	1	4	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:34668200C>G	uc001mvr.1	+	3	423	c.312C>G	c.(310-312)CTC>CTG	p.L104L	EHF_uc009yke.1_Silent_p.L104L|EHF_uc009ykf.1_Silent_p.L107L	NM_012153	NP_036285	Q9NZC4	EHF_HUMAN	ets homologous factor	104	PNT.				cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			GGCAGCTCCTCTACAGCAACT	0.552													316	140					0	0	0	0	G	34668200	G	G	34668200	2	3	201	1	0	0	0	0	0	0	0	1	5003	900	32	2		2	EHF	11	34668200	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	2052742	34668200	100338316	144	36923											
FOLH1	2346	broad.mit.edu	37	chr11	49214404	49214404	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaatatccgaaacattttCatatcctggaggaggtggtt	12	13	9	7	1	1	0	1	0	0	0	3	3	3	2	2	4	2	1	2	4	5	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:49214404C>A	uc001ngy.2	-	4	715	c.454G>T	c.(454-456)GAA>TAA	p.E152*	FOLH1_uc001ngz.2_Nonsense_Mutation_p.E152*|FOLH1_uc009yly.2_Nonsense_Mutation_p.E137*|FOLH1_uc009ylz.2_Nonsense_Mutation_p.E137*|FOLH1_uc009yma.2_5'UTR|FOLH1_uc001nha.2_Nonsense_Mutation_p.E137*	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	152	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GAAACATTTTCATATCCTGGA	0.323													9	108					1.61879e-10	2.56259e-10	1	0	A	49214404	A	A	49214404	4	1	201	1	0	0	0	0	0	1	0	0	6011	835	29	2	1862	2	FOLH1	11	49214404	Nonsense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	14546204	49214404	85792112	145	36924											
OR5D13	390142	broad.mit.edu	37	chr11	55541619	55541619	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgcgatctgcaagtgggCgccagaaaactttctccacc	11	8	10	12	2	2	2	0	0	2	2	3	3	2	2	3	1	3	1	3	1	3	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:55541619C>T	uc010ril.1	+	1	706	c.706C>T	c.(706-708)CGC>TGC	p.R236C		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TGCAAGTGGGCGCCAGAAAAC	0.408													8	67					0	0	0	0	T	55541619	T	T	55541619	3	4	201	1	0	0	0	0	1	0	0	0	11208	768	27	1	708	1	OR5D13	11	55541619	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	6327215	55541619	79464897	146	36925											
OR1S1	219959	broad.mit.edu	37	chr11	57982300	57982300	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcactgaattcattctcctGggatttttcaagcaggatga	11	14	8	8	0	4	2	3	2	1	0	5	4	4	4	1	2	1	1	1	2	2	4	rs139788490		TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:57982300G>T	uc010rkc.1	+	1	84	c.84G>T	c.(82-84)CTG>CTT	p.L28L		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	28	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				TCATTCTCCTGGGATTTTTCA	0.423													10	108					1.76689e-08	2.73645e-08	1	0	T	57982300	T	T	57982300	2	4	201	1	0	0	0	0	0	0	0	1	11026	1335	47	4		4	OR1S1	11	57982300	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	2440681	57982300	77024216	147	36926											
HNRNPUL2	221092	broad.mit.edu	37	chr11	62484600	62484600	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgggctgagcttcctccttCtccagctccccatatgtcac	6	12	7	16	0	2	1	1	1	1	0	6	1	5	1	5	1	2	3	5	1	1	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:62484600C>G	uc001nuw.2	-	11	2035	c.1842G>C	c.(1840-1842)GAG>GAC	p.E614D	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	614					cell killing	nucleus	ATP binding|nucleic acid binding				0						CTTCCTCCTTCTCCAGCTCCC	0.498													3	41					0	0	0	0	G	62484600	G	G	62484600	3	3	201	1	0	0	0	0	1	0	0	0	7314	912	32	2	417	2	HNRNPUL2	11	62484600	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	4502300	62484600	72521916	148	36927											
EHBP1L1	254102	broad.mit.edu	37	chr11	65349905	65349905	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctgggaacccaggagaaaGaagttgaggggtcagggttc	11	7	17	6	0	1	3	1	1	0	2	2	5	1	4	1	5	2	3	1	5	3	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:65349905G>C	uc001oeo.3	+	9	2027	c.1762G>C	c.(1762-1764)GAA>CAA	p.E588Q	EHBP1L1_uc001oep.1_Intron	NM_001099409	NP_001092879	Q8N3D4	EH1L1_HUMAN	tangerin	588	Glu-rich.									central_nervous_system(1)	1						CCAGGAGAAAGAAGTTGAGGG	0.562													8	43					0	0	0	0	C	65349905	C	C	65349905	3	2	201	1	0	0	0	0	1	0	0	0	4998	943	33	2	1796	2	EHBP1L1	11	65349905	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	2865305	65349905	69656611	149	36928											
CTSF	8722	broad.mit.edu	37	chr11	66332076	66332076	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggtcaatgagccaagggCtgcagaggggccggagaggg	10	4	19	8	1	1	3	1	1	0	2	1	4	1	3	2	6	2	2	2	6	2	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:66332076C>A	uc001oip.2	-	11	1364	c.1274G>T	c.(1273-1275)AGC>ATC	p.S425I		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	425					proteolysis	lysosome	cysteine-type endopeptidase activity				0						GAGCCAAGGGCTGCAGAGGGG	0.627													9	3					0.000673444	0.000979347	1	0	A	66332076	A	A	66332076	3	1	201	1	0	0	0	0	1	0	0	0	4051	797	28	4	192	4	CTSF	11	66332076	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	982171	66332076	68674440	150	36929											
UCP3	7352	broad.mit.edu	37	chr11	73717291	73717291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggcgaagctcatctggCgctgcaggccggccaccagc	7	5	15	14	3	2	0	1	0	1	0	2	2	2	1	3	5	3	3	3	5	1	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:73717291C>T	uc001our.2	-	3	615	c.260G>A	c.(259-261)CGC>CAC	p.R87H	UCP3_uc001ous.2_Missense_Mutation_p.R87H	NM_003356	NP_003347	P55916	UCP3_HUMAN	uncoupling protein 3 isoform UCP3L	87	Solcar 1.|Helical; Name=2; (Potential).				mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			pancreas(1)	1	Breast(11;2.08e-05)					GCTCATCTGGCGCTGCAGGCC	0.647													8	33					0	0	0	0	T	73717291	T	T	73717291	3	4	201	1	0	0	0	0	1	0	0	0	17000	768	27	1	702	1	UCP3	11	73717291	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	7385215	73717291	61289225	151	36930											
PCF11	51585	broad.mit.edu	37	chr11	82880841	82880841	+	Frame_Shift_Del	DEL	A	-	-																															aggactacagttccaaagacAtgaacaaatatttgattcac																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:82880841delA	uc001ozx.3	+	8	3809	c.3464delA	c.(3463-3465)CATfs	p.H1155fs	PCF11_uc010rsu.1_Frame_Shift_Del_p.H1286fs	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	1155					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						TTCCAAAGACATGAACAAATA	0.418													---	---	---								-	82880841	-	-	82880841	7	5	201	1	0	1	0	1	0	0	0	0	11627	217	8	0	3494	0	PCF11	11	82880841	Frame_Shift_Del	DEL	A	TCGA-CV-6942-01A-21D-2012-08	9163550	82880841	52125675	152	36931											
SIK3	23387	broad.mit.edu	37	chr11	116728595	116728595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagggatgtatccccaattCttgggcatgactcacagttc	10	12	9	10	0	2	1	1	1	1	0	4	2	3	2	2	2	0	3	2	2	3	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:116728595C>T	uc001ppy.2	-	20	3304	c.3268G>A	c.(3268-3270)GAA>AAA	p.E1090K	SIK3_uc001ppz.2_Missense_Mutation_p.E929K|SIK3_uc001pqa.2_Missense_Mutation_p.E1030K|SIK3_uc001ppw.2_Missense_Mutation_p.E447K|SIK3_uc001ppx.2_Missense_Mutation_p.E468K|SIK3_uc001pqb.2_Missense_Mutation_p.E393K	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	1090						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						ATCCCCAATTCTTGGGCATGA	0.507													12	57					0	0	0	0	T	116728595	T	T	116728595	3	4	201	1	0	0	0	0	1	0	0	0	14384	922	32	2	539	2	SIK3	11	116728595	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	33847754	116728595	18277921	153	36932											
ADAMTS15	170689	broad.mit.edu	37	chr11	130343462	130343462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagcgggcggtggactgcCggggctccgccgggcagcgc	5	3	20	13	6	0	1	0	0	0	1	1	2	1	2	3	6	3	2	3	6	1	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr11:130343462C>T	uc010scd.1	+	8	2599	c.2599C>T	c.(2599-2601)CGG>TGG	p.R867W		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	867	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GGTGGACTGCCGGGGCTCCGC	0.751													5	24					0	0	0	0	T	130343462	T	T	130343462	3	4	201	1	0	0	0	0	1	0	0	0	260	643	23	1	2629	1	ADAMTS15	11	130343462	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	13614867	130343462	4663054	154	36933											
ATN1	1822	broad.mit.edu	37	chr12	7047686	7047686	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccggtggaatgcccatctCtgggcccagtgccccatcgc	5	8	11	17	2	1	0	0	0	1	0	4	1	2	1	5	3	2	0	5	3	1	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:7047686C>G	uc001qrw.1	+	7	2797	c.2560C>G	c.(2560-2562)CTG>GTG	p.L854V	ATN1_uc001qrx.1_Missense_Mutation_p.L854V	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	854					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						ATGCCCATCTCTGGGCCCAGT	0.607											OREG0021641	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	42					0	0	0	0	G	7047686	G	G	7047686	3	3	201	1	0	0	0	0	1	0	0	0	1113	912	32	2	2582	2	ATN1	12	7047686	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08		7047686	126804209	155	36934											
APOBEC1	339	broad.mit.edu	37	chr12	7818459	7818459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggatccattttacctttctCagaagtcatggtgctctgtc	7	15	8	11	1	3	1	2	0	2	1	6	2	4	2	2	2	2	1	2	2	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:7818459C>T	uc001qtb.2	-	1	44	c.10G>A	c.(10-12)GAG>AAG	p.E4K	APOBEC1_uc001qtc.2_5'UTR|APOBEC1_uc010sgf.1_Missense_Mutation_p.E4K	NM_001644	NP_001635	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme	4					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding				0						TTACCTTTCTCAGAAGTCATG	0.378													24	126					0	0	0	0	T	7818459	T	T	7818459	3	4	201	1	0	0	0	0	1	0	0	0	787	835	29	2	720	2	APOBEC1	12	7818459	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	770773	7818459	126033436	156	36935											
SLCO1B1	10599	broad.mit.edu	37	chr12	21377664	21377664	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcctattacaggaggaattCtagctccaatatattttggg	11	14	8	8	0	1	0	0	0	1	0	3	2	3	2	2	3	2	1	2	3	7	8			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:21377664C>G	uc001req.3	+	14	1860	c.1756C>G	c.(1756-1758)CTA>GTA	p.L586V		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	586	Helical; Name=11; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	AGGAGGAATTCTAGCTCCAAT	0.358													21	67					0	0	0	0	G	21377664	G	G	21377664	3	3	201	1	0	0	0	0	1	0	0	0	14787	912	32	2	1806	2	SLCO1B1	12	21377664	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	13559205	21377664	112474231	157	36936											
SOX5	6660	broad.mit.edu	37	chr12	23998941	23998941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggctcgtttttgatgagctCttccattttcctctgcttca	4	18	7	12	2	3	2	1	2	2	0	6	2	5	2	2	1	2	4	2	1	0	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:23998941C>G	uc001rfw.2	-	3	559	c.457G>C	c.(457-459)GAG>CAG	p.E153Q	SOX5_uc001rfx.2_Missense_Mutation_p.E140Q|SOX5_uc001rfy.2_Missense_Mutation_p.E140Q|SOX5_uc010siv.1_Missense_Mutation_p.E140Q|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.E105Q|SOX5_uc001rga.2_Missense_Mutation_p.E118Q	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	153					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						TTGATGAGCTCTTCCATTTTC	0.438													17	85					0	0	0	0	G	23998941	G	G	23998941	3	3	201	1	0	0	0	0	1	0	0	0	15018	922	32	2	1896	2	SOX5	12	23998941	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	2621277	23998941	109852954	158	36937											
STAT6	6778	broad.mit.edu	37	chr12	57500498	57500498	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggccagcctcagcccccttCtgcagggcttctcggagaag	6	8	12	15	1	3	1	1	0	2	1	4	2	3	1	4	3	3	2	4	3	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:57500498C>G	uc009zpe.2	-	5	707	c.456G>C	c.(454-456)CAG>CAC	p.Q152H	STAT6_uc009zpf.2_Missense_Mutation_p.Q152H|STAT6_uc001sna.2_Missense_Mutation_p.Q152H|STAT6_uc010srb.1_Missense_Mutation_p.Q42H|STAT6_uc010src.1_Missense_Mutation_p.Q42H|STAT6_uc010srd.1_Missense_Mutation_p.Q42H|STAT6_uc009zpg.2_Missense_Mutation_p.Q201H	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	152					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						CAGCCCCCTTCTGCAGGGCTT	0.567													55	122					0	0	0	0	G	57500498	G	G	57500498	3	3	201	1	0	0	0	0	1	0	0	0	15336	912	32	2	2159	2	STAT6	12	57500498	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	33501557	57500498	76351397	159	36938											
GLI1	2735	broad.mit.edu	37	chr12	57864291	57864291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcccagcactacctgcttCgggcaagatatgcttcagcc	8	9	9	15	1	1	1	1	0	0	1	2	1	1	1	3	1	6	4	3	1	3	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:57864291C>T	uc001snx.2	+	12	1846	c.1768C>T	c.(1768-1770)CGG>TGG	p.R590W	GLI1_uc009zpq.2_Missense_Mutation_p.R462W	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	590					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CTACCTGCTTCGGGCAAGATA	0.632													13	63					0	0	0	0	T	57864291	T	T	57864291	3	4	201	1	0	0	0	0	1	0	0	0	6474	875	31	1	1810	1	GLI1	12	57864291	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	363793	57864291	75987604	160	36939											
CYP27B1	1594	broad.mit.edu	37	chr12	58158990	58158990	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gagccgagcagaaccgcggcGatgccttgtcgggagggggc	7	4	19	11	5	0	1	0	0	0	1	1	5	0	2	3	4	4	1	3	4	1	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:58158990G>C	uc001spz.1	-	4	746	c.594C>G	c.(592-594)ATC>ATG	p.I198M	CYP27B1_uc001sqa.1_Translation_Start_Site|CYP27B1_uc001sqb.1_Missense_Mutation_p.R79G|CYP27B1_uc001sqc.1_Missense_Mutation_p.R79G	NM_000785	NP_000776	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B,	198					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)	3	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	GAACCGCGGCGATGCCTTGTC	0.692											OREG0021953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	32					0	0	0	0	C	58158990	C	C	58158990	3	2	201	1	0	0	0	0	1	0	0	0	4176	1048	37	3	956	3	CYP27B1	12	58158990	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	294699	58158990	75692905	161	36940											
DPY19L2	283417	broad.mit.edu	37	chr12	64061889	64061890	+	Frame_Shift_Ins	INS	-	T	T																															gcgcctgcagttcctgcaccINSttttcccggagctgcgccag																										TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:64061889_64061890insT	uc001srp.1	-	1	465_466	c.284_285insA	c.(283-285)AAGfs	p.K95fs	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	95					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		GTTCCTGCACCTTTTCCCGGAG	0.609													---	---	---								T	64061890	T	T	64061889	7	5	201	1	0	1	1	0	0	0	0	0	4763	680	24	0	2079	0	DPY19L2	12	64061889	Frame_Shift_Ins	INS	-	TCGA-CV-6942-01A-21D-2012-08	5902899	64061889	69790006	162	36941											
DUSP6	1848	broad.mit.edu	37	chr12	89745576	89745576	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgaagcggtcccggtcctCgccgcgcgtgaagagcgcgc	5	5	17	14	8	0	3	0	2	0	1	3	3	2	3	3	3	2	0	3	3	2	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:89745576C>T	uc001tay.2	-	1	721	c.241G>A	c.(241-243)GAG>AAG	p.E81K	DUSP6_uc001taz.2_Missense_Mutation_p.E81K	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	81	Rhodanese.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						TCCCGGTCCTCGCCGCGCGTG	0.677													4	28					0	0	0	0	T	89745576	T	T	89745576	3	4	201	1	0	0	0	0	1	0	0	0	4851	893	31	1	916	1	DUSP6	12	89745576	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	25683687	89745576	44106319	163	36942											
SLC24A6	80024	broad.mit.edu	37	chr12	113758155	113758155	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccagagcccatgccagggtGaccctgccacggaagagcat	10	4	12	15	1	0	3	0	1	0	2	0	4	0	4	5	2	4	1	5	2	1	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:113758155G>A	uc001tvc.2	-	7	885	c.675C>T	c.(673-675)GTC>GTT	p.V225V	SLC24A6_uc001tuz.2_5'Flank|SLC24A6_uc001tva.2_RNA|SLC24A6_uc001tvb.2_Intron	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	225	Extracellular (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						ATGCCAGGGTGACCCTGCCAC	0.602													44	159					0	0	0	0	A	113758155	A	A	113758155	2	1	201	1	0	0	0	0	0	0	0	1	14534	1277	45	2		2	SLC24A6	12	113758155	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	24012579	113758155	20093740	164	36943											
COQ5	84274	broad.mit.edu	37	chr12	120941685	120941685	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctatcatgtccttgaactCttcctgaaacacaaggaaag	13	12	6	10	0	3	2	1	2	2	0	5	3	5	3	2	1	2	0	2	1	5	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:120941685C>T	uc001tyn.2	-	7	906	c.886G>A	c.(886-888)GAG>AAG	p.E296K	COQ5_uc001tyo.2_Missense_Mutation_p.E215K|COQ5_uc010szj.1_Missense_Mutation_p.E222K	NM_032314	NP_115690	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase	296					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCCTTGAACTCTTCCTGAAAC	0.413													20	70					0	0	0	0	T	120941685	T	T	120941685	3	4	201	1	0	0	0	0	1	0	0	0	3763	922	32	2	101	2	COQ5	12	120941685	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	7183530	120941685	12910210	165	36944											
TMEM132D	121256	broad.mit.edu	37	chr12	129694177	129694177	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacggccaccgtcttccccGtgaggatggctgtgttcagg	5	9	15	12	3	2	1	1	1	1	0	3	3	3	3	4	5	0	2	4	5	0	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr12:129694177G>A	uc009zyl.1	-	5	1659	c.1331C>T	c.(1330-1332)ACG>ATG	p.T444M		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	444	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CGTCTTCCCCGTGAGGATGGC	0.592													11	39					0	0	0	0	A	129694177	A	A	129694177	3	1	201	1	0	0	0	0	1	0	0	0	16113	1145	40	1	1988	1	TMEM132D	12	129694177	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	8752492	129694177	4157718	166	36945											
TUBA3C	7278	broad.mit.edu	37	chr13	19753481	19753481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggacccgagcacctacCgaccacagtgggctccaggt	9	5	11	16	2	0	0	0	0	0	0	2	3	2	1	6	3	2	2	6	3	1	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr13:19753481C>T	uc009zzj.2	-	2	275	c.226G>A	c.(226-228)GAT>AAT	p.D76N		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	76					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GAGCACCTACCGACCACAGTG	0.587													7	67					0	0	0	0	T	19753481	T	T	19753481	3	4	201	1	0	0	0	0	1	0	0	0	16814	666	23	1	1142	1	TUBA3C	13	19753481	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08		19753481	95416397	167	36946											
KIAA0564	23078	broad.mit.edu	37	chr13	42335296	42335296	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatattctcggggtctgttGagcaggtgaaggaatctgtc	9	13	13	6	1	3	2	0	2	3	0	5	3	3	3	0	4	1	2	0	4	4	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr13:42335296G>C	uc001uyj.2	-	21	2464	c.2394C>G	c.(2392-2394)CTC>CTG	p.L798L	KIAA0564_uc001uyk.2_Silent_p.L798L	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	798						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		GGGGTCTGTTGAGCAGGTGAA	0.363													22	80					0	0	0	0	C	42335296	C	C	42335296	2	2	201	1	0	0	0	0	0	0	0	1	8224	1277	45	2		2	KIAA0564	13	42335296	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	22581815	42335296	72834582	168	36947											
CDADC1	81602	broad.mit.edu	37	chr13	49852553	49852553	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgcttttcctgttggatCtgagtatgctgacttcccac	7	15	8	11	0	1	2	0	2	1	0	3	3	3	3	2	1	2	4	2	1	2	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr13:49852553C>A	uc001vcu.2	+	7	1194	c.1118C>A	c.(1117-1119)TCT>TAT	p.S373Y	CDADC1_uc010tgk.1_Missense_Mutation_p.S175Y|CDADC1_uc001vcv.2_RNA	NM_030911	NP_112173	Q9BWV3	CDAC1_HUMAN	cytidine and dCMP deaminase domain containing 1	373							hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		Lung NSC(96;0.000705)|Breast(56;0.0011)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;1.06e-08)|COAD - Colon adenocarcinoma(199;0.216)		CCTGTTGGATCTGAGTATGCT	0.413													34	115					4.31634e-10	6.78281e-10	1	0	A	49852553	A	A	49852553	3	1	201	1	0	0	0	0	1	0	0	0	3068	913	32	2	1144	2	CDADC1	13	49852553	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	7517257	49852553	65317325	169	36948											
RNASE4	6038	broad.mit.edu	37	chr14	21167749	21167749	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaagcgcttcaacaccttCatccatgaagatatctggaa	13	10	7	11	1	3	2	2	1	1	1	4	3	4	3	2	1	3	2	2	1	5	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr14:21167749C>T	uc001vxy.3	+	2	782	c.219C>T	c.(217-219)TTC>TTT	p.F73F	RNASE4_uc001vxx.3_RNA|RNASE4_uc001vya.2_Silent_p.F73F	NM_002937	NP_002928	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4 precursor	73					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)	1	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		TCAACACCTTCATCCATGAAG	0.478													26	109					0	0	0	0	T	21167749	T	T	21167749	2	4	201	1	0	0	0	0	0	0	0	1	13471	825	29	2		2	RNASE4	14	21167749	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08		21167749	86181791	170	36949											
SOS2	6655	broad.mit.edu	37	chr14	50655405	50655405	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgtcatcctgatcaaacAtgtccatcaaaacctgagaa	15	10	5	11	0	3	2	3	2	0	1	5	3	5	2	3	0	2	0	3	0	5	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr14:50655405A>C	uc001wxs.3	-	5	622	c.524T>G	c.(523-525)ATG>AGG	p.M175R	SOS2_uc010tql.1_Missense_Mutation_p.M175R	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	175					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					CTGATCAAACATGTCCATCAA	0.313													8	29					0	0	0	0	C	50655405	C	C	50655405	3	2	201	1	0	0	0	0	1	0	0	0	15001	217	8	5	3550	5	SOS2	14	50655405	Missense_Mutation	SNP	A	TCGA-CV-6942-01A-21D-2012-08	29487656	50655405	56694135	171	36950											
NIN	51199	broad.mit.edu	37	chr14	51233551	51233551	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtttgtttgtcagattctCatattctgccaacttctctg	8	18	6	9	0	4	1	2	0	3	1	6	1	4	1	1	0	2	2	1	0	3	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr14:51233551C>G	uc001wym.2	-	13	1683	c.1492G>C	c.(1492-1494)GAG>CAG	p.E498Q	NIN_uc001wyi.2_Missense_Mutation_p.E498Q|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.E498Q|NIN_uc010tqp.1_Missense_Mutation_p.E504Q|NIN_uc001wyo.2_Missense_Mutation_p.E498Q	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	498	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GTCAGATTCTCATATTCTGCC	0.358			T	PDGFRB	MPD								50	81					0	0	0	0	G	51233551	G	G	51233551	3	3	201	1	0	0	0	0	1	0	0	0	10471	835	29	2	5133	2	NIN	14	51233551	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	578146	51233551	56115989	172	36951											
SLC8A3	6547	broad.mit.edu	37	chr14	70518746	70518746	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaatgatgacttctagtttGgggtgttcacccaatactgg	9	14	10	8	0	3	2	2	2	1	0	3	2	3	2	1	3	1	2	1	3	4	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr14:70518746G>T	uc001xly.2	-	5	2746	c.1992C>A	c.(1990-1992)CCC>CCA	p.P664P	SLC8A3_uc001xlu.2_Silent_p.P21P|SLC8A3_uc001xlv.2_Silent_p.P35P|SLC8A3_uc001xlw.2_Silent_p.P661P|SLC8A3_uc001xlx.2_Silent_p.P662P|SLC8A3_uc001xlz.2_Silent_p.P658P|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_Silent_p.P21P	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	664	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CTTCTAGTTTGGGGTGTTCAC	0.383													27	59					1.7367e-05	2.578e-05	1	0	T	70518746	T	T	70518746	2	4	201	1	0	0	0	0	0	0	0	1	14772	1335	47	4		4	SLC8A3	14	70518746	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	19285195	70518746	36830794	173	36952											
HEATR4	399671	broad.mit.edu	37	chr14	73989500	73989500	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgaggaacccaggaacttGaagctaacaggtttctgagg	12	9	12	8	0	1	3	0	3	1	0	1	5	1	5	1	4	4	2	1	4	4	4	rs150475805		TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr14:73989500G>A	uc010tub.1	-	3	679	c.357C>T	c.(355-357)TTC>TTT	p.F119F	HEATR4_uc010tua.1_Silent_p.F72F	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		CCAGGAACTTGAAGCTAACAG	0.488													16	78					0	0	0	0	A	73989500	A	A	73989500	2	1	201	1	0	0	0	0	0	0	0	1	7069	1281	45	2		2	HEATR4	14	73989500	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	3470754	73989500	33360040	174	36953											
TJP1	7082	broad.mit.edu	37	chr15	30008860	30008860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgattctgagaatgcgctGgctttgcaggctcggagaga	9	11	14	7	2	1	3	0	2	1	2	2	6	1	4	0	3	2	4	0	3	1	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:30008860G>A	uc001zcr.2	-	23	4632	c.4157C>T	c.(4156-4158)CCA>CTA	p.P1386L	TJP1_uc010azl.2_Missense_Mutation_p.P1374L|TJP1_uc001zcq.2_Missense_Mutation_p.P1310L|TJP1_uc001zcs.2_Missense_Mutation_p.P1306L	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1386					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		AGAATGCGCTGGCTTTGCAGG	0.408													12	43					0	0	0	0	A	30008860	A	A	30008860	3	1	201	1	0	0	0	0	1	0	0	0	15995	1348	47	4	1113	4	TJP1	15	30008860	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08		30008860	72522532	175	36954											
TRPM1	4308	broad.mit.edu	37	chr15	31358388	31358388	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gccaggatgaagtgggtgtgGgagttgttgagcacagagag	10	8	19	4	0	0	3	0	2	0	1	0	6	0	5	1	3	1	3	1	3	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:31358388G>A	uc001zfm.2	-	6	743	c.615C>T	c.(613-615)TCC>TCT	p.S205S	TRPM1_uc010azy.2_Silent_p.S118S|TRPM1_uc001zfl.2_RNA|uc010ubm.1_5'Flank|MIR211_hsa-mir-211|MI0000287_5'Flank	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	205	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AGTGGGTGTGGGAGTTGTTGA	0.537													16	94					0	0	0	0	A	31358388	A	A	31358388	2	1	201	1	0	0	0	0	0	0	0	1	16652	1219	43	4		4	TRPM1	15	31358388	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1349528	31358388	71173004	176	36955											
AQR	9716	broad.mit.edu	37	chr15	35189848	35189848	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttcctcggtgtcttcatCttccacatccgcatctttcc	4	16	5	16	2	4	0	1	0	3	0	9	0	8	0	4	1	1	2	4	1	0	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:35189848C>G	uc001ziv.2	-	21	2483	c.2302G>C	c.(2302-2304)GAT>CAT	p.D768H		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	768						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		GTGTCTTCATCTTCCACATCC	0.348													19	33					0	0	0	0	G	35189848	G	G	35189848	3	3	201	1	0	0	0	0	1	0	0	0	835	913	32	2	2215	2	AQR	15	35189848	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	3831460	35189848	67341544	177	36956											
FAM82A2	55177	broad.mit.edu	37	chr15	41030186	41030186	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagcaccacctgccaagaaGaaagtgagccatggggtttt	13	8	11	9	0	0	3	0	1	0	2	0	3	0	3	4	2	3	2	4	2	4	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:41030186G>A	uc001zmo.1	-	9	1246	c.1102C>T	c.(1102-1104)CTT>TTT	p.L368F	FAM82A2_uc001zmp.1_Missense_Mutation_p.L368F|FAM82A2_uc001zmq.1_Missense_Mutation_p.L368F	NM_018145	NP_060615	Q96TC7	RMD3_HUMAN	family with sequence similarity 82, member A2	368					apoptosis|cell differentiation	integral to membrane|microtubule|mitochondrial membrane|nucleus|spindle pole	protein binding				0						CTGCCAAGAAGAAAGTGAGCC	0.458													38	164					0	0	0	0	A	41030186	A	A	41030186	3	1	201	1	0	0	0	0	1	0	0	0	5663	942	33	2	330	2	FAM82A2	15	41030186	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	5840338	41030186	61501206	178	36957											
INO80	54617	broad.mit.edu	37	chr15	41350928	41350928	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacatcctgcaccaccagctGatagctggtaataaccacat	13	9	6	13	0	0	1	0	1	0	0	1	1	1	1	4	1	5	4	4	1	4	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:41350928G>A	uc001zni.2	-	16	2107	c.1894C>T	c.(1894-1896)CAG>TAG	p.Q632*	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	632	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.|Helicase ATP-binding.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						ACCACCAGCTGATAGCTGGTA	0.453													21	71					0	0	0	0	A	41350928	A	A	41350928	4	1	201	1	0	0	0	0	0	1	0	0	7785	1299	45	2	2860	2	INO80	15	41350928	Nonsense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	320742	41350928	61180464	179	36958											
PLA2G4D	283748	broad.mit.edu	37	chr15	42375422	42375422	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgcccgctcagctctgtctCtagggctgccatgtagtgga	5	10	13	13	2	3	0	1	0	2	0	4	1	3	1	2	2	2	4	2	2	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:42375422C>G	uc001zox.2	-	8	741	c.646G>C	c.(646-648)GAG>CAG	p.E216Q		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	216					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		AGCTCTGTCTCTAGGGCTGCC	0.632													10	37					0	0	0	0	G	42375422	G	G	42375422	3	3	201	1	0	0	0	0	1	0	0	0	12059	922	32	2	1862	2	PLA2G4D	15	42375422	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1024494	42375422	60155970	180	36959											
UNC13C	440279	broad.mit.edu	37	chr15	54305735	54305735	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcctggggaataagaagtaAgtctttggacagaactgtcc	13	10	11	7	0	1	2	0	0	1	2	3	4	3	4	2	3	1	1	2	3	5	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:54305735A>T	uc002ack.2	+	1	635	c.635A>T	c.(634-636)AAG>ATG	p.K212M		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	212					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATAAGAAGTAAGTCTTTGGAC	0.438													23	96					0	0	0	0	T	54305735	T	T	54305735	3	4	201	1	0	0	0	0	1	0	0	0	17054	72	3	5	637	5	UNC13C	15	54305735	Missense_Mutation	SNP	A	TCGA-CV-6942-01A-21D-2012-08	11930313	54305735	48225657	181	36960											
RAB8B	51762	broad.mit.edu	37	chr15	63481934	63481934	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacgccttcaacaccaccttCatctccaccatcggtgaggg	9	8	8	16	2	3	1	2	1	1	0	5	2	3	1	5	2	1	0	5	2	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:63481934C>T	uc002alz.2	+	1	207	c.111C>T	c.(109-111)TTC>TTT	p.F37F	RAB8B_uc010uih.1_Silent_p.F37F	NM_016530	NP_057614	Q92930	RAB8B_HUMAN	RAB8B, member RAS oncogene family	37	Effector region (By similarity).				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)|kidney(1)	2						ACACCACCTTCATCTCCACCA	0.468													9	35					0	0	0	0	T	63481934	T	T	63481934	2	4	201	1	0	0	0	0	0	0	0	1	13022	825	29	2		2	RAB8B	15	63481934	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	9176199	63481934	39049458	182	36961											
SLC24A1	9187	broad.mit.edu	37	chr15	65916745	65916745	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acactgagcatgacagtggaGaatatccccagtatgcctaa	14	8	9	10	0	0	3	0	2	0	1	1	4	1	3	3	1	2	2	3	1	4	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:65916745G>A	uc010ujf.1	+	2	614	c.327G>A	c.(325-327)GAG>GAA	p.E109E	SLC24A1_uc010ujd.1_Silent_p.E109E|SLC24A1_uc010uje.1_Silent_p.E109E|SLC24A1_uc010ujg.1_Silent_p.E109E|SLC24A1_uc010ujh.1_Silent_p.E109E	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	109	Extracellular (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						TGACAGTGGAGAATATCCCCA	0.493													4	21					0	0	0	0	A	65916745	A	A	65916745	2	1	201	1	0	0	0	0	0	0	0	1	14529	933	33	2		2	SLC24A1	15	65916745	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	2434811	65916745	36614647	183	36962											
SLC24A1	9187	broad.mit.edu	37	chr15	65918077	65918077	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccgagagatcctcaacctCacctggtggcccttattccg	7	10	8	16	2	2	1	2	0	0	1	5	3	5	1	6	2	1	0	6	2	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:65918077C>T	uc010ujf.1	+	2	1946	c.1659C>T	c.(1657-1659)CTC>CTT	p.L553L	SLC24A1_uc010ujd.1_Silent_p.L553L|SLC24A1_uc010uje.1_Silent_p.L553L|SLC24A1_uc010ujg.1_Silent_p.L553L|SLC24A1_uc010ujh.1_Silent_p.L553L	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	553	Cytoplasmic (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						TCCTCAACCTCACCTGGTGGC	0.517													25	104					0	0	0	0	T	65918077	T	T	65918077	2	4	201	1	0	0	0	0	0	0	0	1	14529	813	29	2		2	SLC24A1	15	65918077	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1332	65918077	36613315	184	36963											
SGK269	79834	broad.mit.edu	37	chr15	77473623	77473623	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccttcattactaatcacttCtgtgctcccactcagaataa	11	13	3	14	0	4	1	3	0	1	1	5	1	5	1	2	0	2	1	2	0	4	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:77473623C>G	uc002bcm.2	-	3	954	c.646G>C	c.(646-648)GAA>CAA	p.E216Q	SGK269_uc002bcn.2_Missense_Mutation_p.E216Q	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	216					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		CTAATCACTTCTGTGCTCCCA	0.458													34	126					0	0	0	0	G	77473623	G	G	77473623	3	3	201	1	0	0	0	0	1	0	0	0	14276	922	32	2	4610	2	SGK269	15	77473623	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	11555546	77473623	25057769	185	36964											
ZNF710	374655	broad.mit.edu	37	chr15	90616485	90616485	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcgcccgtgaagccattCaaatgcaaggtacccggtca	11	7	9	14	3	2	1	2	1	0	0	3	1	2	1	3	2	3	2	3	2	4	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:90616485C>A	uc002bov.1	+	3	1764	c.1641C>A	c.(1639-1641)TTC>TTA	p.F547L		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	547	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			TGAAGCCATTCAAATGCAAGG	0.602													14	58					1.15088e-07	1.7508e-07	1	0	A	90616485	A	A	90616485	3	1	201	1	0	0	0	0	1	0	0	0	18182	825	29	2	1647	2	ZNF710	15	90616485	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	13142862	90616485	11914907	186	36965											
PRC1	9055	broad.mit.edu	37	chr15	91522476	91522476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcatagtagttttttaacCgcacaatctcagcatcgtgg	10	14	7	10	2	2	0	2	0	1	0	4	0	2	0	1	1	2	4	1	1	4	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr15:91522476C>T	uc002bqm.2	-	8	1176	c.1019G>A	c.(1018-1020)CGG>CAG	p.R340Q	PRC1_uc002bqn.2_Missense_Mutation_p.R340Q|PRC1_uc002bqo.2_Missense_Mutation_p.R340Q|PRC1_uc010uqs.1_Missense_Mutation_p.R299Q	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	340	Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					GTTTTTTAACCGCACAATCTC	0.413													8	66					0	0	0	0	T	91522476	T	T	91522476	3	4	201	1	0	0	0	0	1	0	0	0	12508	652	23	1	875	1	PRC1	15	91522476	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	905991	91522476	11008916	187	36966											
IFT140	9742	broad.mit.edu	37	chr16	1614075	1614075	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggcgtctcctgcacggcttCgcatacaaacagccggggct	7	7	12	15	5	1	0	0	0	1	0	3	0	1	0	2	4	4	4	2	4	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr16:1614075C>T	uc002cmb.2	-	17	2352	c.1990G>A	c.(1990-1992)GAA>AAA	p.E664K	IFT140_uc002clz.2_Missense_Mutation_p.E315K	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	664										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				TGCACGGCTTCGCATACAAAC	0.577													14	58					0	0	0	0	T	1614075	T	T	1614075	3	4	201	1	0	0	0	0	1	0	0	0	7595	893	31	1	2458	1	IFT140	16	1614075	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08		1614075	88740678	188	36967											
BTBD12	84464	broad.mit.edu	37	chr16	3656656	3656656	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacttggcactgctgttgtCaaacaggaaggaggaggctg	10	8	16	7	0	1	0	1	0	0	0	1	4	1	4	0	6	2	4	0	6	2	2	rs148887586		TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr16:3656656C>G	uc002cvp.2	-	3	1206	c.579G>C	c.(577-579)TTG>TTC	p.L193F	BTBD12_uc002cvq.1_Missense_Mutation_p.L193F	NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	193	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CTGCTGTTGTCAAACAGGAAG	0.512								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				41	143					0	0	0	0	G	3656656	G	G	3656656	3	3	201	1	0	0	0	0	1	0	0	0	1545	825	29	2	4977	2	BTBD12	16	3656656	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	2042581	3656656	86698097	189	36968											
PLK1	5347	broad.mit.edu	37	chr16	23698820	23698820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccctgcctgagcgtccccGggaaaaagaagaaccagtgg	11	4	12	14	2	0	3	0	1	0	2	1	4	1	4	6	2	3	0	6	2	4	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr16:23698820G>A	uc002dlz.1	+	6	1120	c.1067G>A	c.(1066-1068)CGG>CAG	p.R356Q		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	356					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		GAGCGTCCCCGGGAAAAAGAA	0.592													10	136					0	0	0	0	A	23698820	A	A	23698820	3	1	201	1	0	0	0	0	1	0	0	0	12149	1116	39	1	1089	1	PLK1	16	23698820	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	20042164	23698820	66655933	190	36969											
RABEP2	79874	broad.mit.edu	37	chr16	28925721	28925721	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcagggaggagctgctgcCgaccccaccgccaagggaga	9	2	17	13	2	0	1	0	0	0	1	0	5	0	3	5	4	3	3	5	4	1	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr16:28925721C>T	uc002drq.2	-	5	778	c.730G>A	c.(730-732)GGC>AGC	p.G244S	uc010vct.1_Intron|RABEP2_uc010vdf.1_Missense_Mutation_p.G173S|RABEP2_uc010byn.2_Missense_Mutation_p.G244S|RABEP2_uc002drr.2_Missense_Mutation_p.G244S	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	244					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						GAGCTGCTGCCGACCCCACCG	0.672													10	35					0	0	0	0	T	28925721	T	T	28925721	3	4	201	1	0	0	0	0	1	0	0	0	13027	652	23	1	1015	1	RABEP2	16	28925721	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	5226901	28925721	61429032	191	36970											
FHOD1	29109	broad.mit.edu	37	chr16	67272351	67272351	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actggagctatacagcttttCtgcaaaaggtagggtataaa	14	11	10	6	0	1	0	0	0	1	0	1	1	1	1	0	3	4	5	0	3	8	7			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr16:67272351C>T	uc002esl.2	-	4	486	c.374_splice	c.e4-1	p.E125_splice	FHOD1_uc010ced.2_5'UTR|FHOD1_uc010vjh.1_5'UTR	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1						actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TACAGCTTTTCTGCAAAAGGT	0.502													4	21					0	0	0	0	T	67272351	T	T	67272351	5	4	201	1	0	0	0	0	0	0	1	0	5914	927	32	2	3197	2	FHOD1	16	67272351	Splice_Site	SNP	C	TCGA-CV-6942-01A-21D-2012-08	38346630	67272351	23082402	192	36971											
C16orf46	123775	broad.mit.edu	37	chr16	81095518	81095518	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaagcagatgtcgctaattgCcctggaagcagtgctggggc	10	8	14	9	1	0	1	0	0	0	1	1	2	0	2	1	3	4	4	1	3	3	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr16:81095518C>T	uc002fgc.3	-	4	695	c.436G>A	c.(436-438)GCA>ACA	p.A146T	C16orf46_uc010chf.2_Missense_Mutation_p.A146T|C16orf46_uc010vno.1_5'UTR	NM_152337	NP_689550	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 2	146											0						TCGCTAATTGCCCTGGAAGCA	0.572													5	188					0	0	0	0	T	81095518	T	T	81095518	3	4	201	1	0	0	0	0	1	0	0	0	1821	739	26	4	783	4	C16orf46	16	81095518	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	13823167	81095518	9259235	193	36972											
CTNS	1497	broad.mit.edu	37	chr17	3550808	3550808	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctcgaccaacgtcagcctCaccctgcggtaagttcctgg	8	8	10	15	3	2	0	2	0	0	0	4	1	3	0	4	2	4	3	4	2	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:3550808C>T	uc002fwb.2	+	4	725	c.132C>T	c.(130-132)CTC>CTT	p.L44L	CTNS_uc002fwa.2_Silent_p.L44L|CTNS_uc010ckj.2_Silent_p.L44L|CTNS_uc010vrv.1_Intron|CTNS_uc010vrw.1_Intron	NM_004937	NP_004928	O60931	CTNS_HUMAN	cystinosin isoform 2	44	Lumenal (Potential).				ATP metabolic process|brain development|cognition|glutathione metabolic process	integral to membrane|late endosome|lysosomal membrane	L-cystine transmembrane transporter activity				0				COAD - Colon adenocarcinoma(5;0.0829)	L-Cystine(DB00138)	ACGTCAGCCTCACCCTGCGGT	0.602													7	27					0	0	0	0	T	3550808	T	T	3550808	2	4	201	1	0	0	0	0	0	0	0	1	4038	813	29	2		2	CTNS	17	3550808	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08		3550808	77644402	194	36973											
SPNS2	124976	broad.mit.edu	37	chr17	4436304	4436304	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttctcctccctggccacgtCggctgtctccttcgccacgg	2	11	9	19	4	2	0	0	0	2	0	7	0	3	0	5	3	0	1	5	3	0	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:4436304C>T	uc002fxx.2	+	7	1182	c.968C>T	c.(967-969)TCG>TTG	p.S323L		NM_001124758	NP_001118230	Q8IVW8	SPNS2_HUMAN	spinster homolog 2	323	Helical; (Potential).				lipid transport|transmembrane transport	integral to membrane					0						CTGGCCACGTCGGCTGTCTCC	0.662													15	51					0	0	0	0	T	4436304	T	T	4436304	3	4	201	1	0	0	0	0	1	0	0	0	15141	893	31	1	994	1	SPNS2	17	4436304	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	885496	4436304	76758906	195	36974											
ZFP3	124961	broad.mit.edu	37	chr17	4996049	4996049	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaccagagaattcatactgGagagaaaccccatcaatgta	16	7	7	11	0	2	2	2	0	0	2	2	5	2	3	4	1	2	1	4	1	5	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:4996049G>T	uc002gaq.2	+	2	1375	c.1250G>T	c.(1249-1251)GGA>GTA	p.G417V		NM_153018	NP_694563	Q96NJ6	ZFP3_HUMAN	zinc finger protein-3	417					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTCATACTGGAGAGAAACCC	0.428													15	63					2.61681e-11	4.20454e-11	1	0	T	4996049	T	T	4996049	3	4	201	1	0	0	0	0	1	0	0	0	17710	1174	41	2	1252	2	ZFP3	17	4996049	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	559745	4996049	76199161	196	36975											
ALOX12	239	broad.mit.edu	37	chr17	6905118	6905118	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cggtgcctcccaggactgcaCcccatcttcaaggtacttat	8	10	8	15	1	2	0	1	0	1	0	3	1	3	1	4	3	3	2	4	3	3	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:6905118C>A	uc002gdx.3	+	8	1202	c.1149C>A	c.(1147-1149)CAC>CAA	p.H383Q	uc002gdy.1_RNA	NM_000697	NP_000688	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	383	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			central_nervous_system(1)	1						CAGGACTGCACCCCATCTTCA	0.488													16	68					6.31663e-08	9.71266e-08	1	0	A	6905118	A	A	6905118	3	1	201	1	0	0	0	0	1	0	0	0	536	506	18	4	1179	4	ALOX12	17	6905118	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1909069	6905118	74290092	197	36976											
TP53	7157	broad.mit.edu	37	chr17	7576855	7576855	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcccaagacttagtacctGaagggtgaaatattctccat	12	11	9	9	0	1	3	0	2	1	1	3	3	2	3	3	2	1	1	3	2	6	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:7576855G>A	uc002gim.2	-	9	1185	c.991C>T	c.(991-993)CAG>TAG	p.Q331*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.Q331*|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Nonsense_Mutation_p.Q199*|TP53_uc010cng.1_Nonsense_Mutation_p.Q199*|TP53_uc002gii.1_Nonsense_Mutation_p.Q199*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q331*|TP53_uc010cni.1_Nonsense_Mutation_p.Q331*|TP53_uc002gij.2_Nonsense_Mutation_p.Q331*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	331	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(14)|p.0?(7)|p.Q331P(3)|p.Q331fs*6(1)|p.?(1)|p.Q331Q(1)|p.Q331R(1)|p.Q331H(1)|p.Q331fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTAGTACCTGAAGGGTGAAA	0.448		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	51					0	0	0	0	A	7576855	A	A	7576855	4	1	201	1	0	0	0	0	0	1	0	0	16448	1299	45	2	291	2	TP53	17	7576855	Nonsense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	671737	7576855	73618355	198	36977											
TP53	7157	broad.mit.edu	37	chr17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcaccaccacactatgtcGaaaagtgtttctgtcatcca	11	10	8	12	1	2	0	1	0	1	0	4	1	3	0	3	1	0	2	3	1	3	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	25					0	0	0	0	A	7578212	A	A	7578212	4	1	201	1	0	0	0	0	0	1	0	0	16448	1066	37	1	657	1	TP53	17	7578212	Nonsense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1357	7578212	73616998	199	36978											
PIK3R5	23533	broad.mit.edu	37	chr17	8790443	8790443	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttcagggggcaggtgcatGaggcccagtacattgcgctc	8	8	14	11	1	1	1	1	1	0	0	2	1	1	1	1	4	3	4	1	4	1	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:8790443G>C	uc002glt.2	-	12	1942	c.1875C>G	c.(1873-1875)CTC>CTG	p.L625L	PIK3R5_uc010vuz.1_Silent_p.L625L|PIK3R5_uc002glu.3_Silent_p.L239L	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	625					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GCAGGTGCATGAGGCCCAGTA	0.622													8	37					0	0	0	0	C	8790443	C	C	8790443	2	2	201	1	0	0	0	0	0	0	0	1	11977	1277	45	2		2	PIK3R5	17	8790443	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1212231	8790443	72404767	200	36979											
ZNF624	57547	broad.mit.edu	37	chr17	16527194	16527194	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgaaggcctttccacattCattacatttatagggttttt	11	17	6	7	0	1	1	1	1	0	0	2	1	2	1	2	2	1	1	2	2	5	8			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:16527194C>T	uc010cpi.1	-	6	1089	c.1006G>A	c.(1006-1008)GAA>AAA	p.E336K		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	336	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TTTCCACATTCATTACATTTA	0.368													24	79					0	0	0	0	T	16527194	T	T	16527194	3	4	201	1	0	0	0	0	1	0	0	0	18115	835	29	2	1595	2	ZNF624	17	16527194	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	7736751	16527194	64668016	201	36980											
MPRIP	23164	broad.mit.edu	37	chr17	17061836	17061836	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggcagagctgggggagccGgaccctgagcagaagaggag	11	2	20	8	1	0	4	0	1	0	3	0	8	0	7	2	5	3	3	2	5	1	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:17061836G>A	uc002gqu.1	+	14	1622	c.1566G>A	c.(1564-1566)CCG>CCA	p.P522P	MPRIP_uc002gqv.1_Silent_p.P522P|MPRIP_uc002gqw.1_Silent_p.P277P	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	522						cytoplasm|cytoskeleton	actin binding				0						TGGGGGAGCCGGACCCTGAGC	0.632													9	42					0	0	0	0	A	17061836	A	A	17061836	2	1	201	1	0	0	0	0	0	0	0	1	9796	1103	39	1		1	MPRIP	17	17061836	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	534642	17061836	64133374	202	36981											
ULK2	9706	broad.mit.edu	37	chr17	19748690	19748690	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacgagcaaaaccaaaatccGctatttcacaaaacagaaag	21	5	5	10	2	1	1	1	0	0	1	2	2	2	1	2	0	4	2	2	0	9	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:19748690G>A	uc002gwm.3	-	7	979	c.470C>T	c.(469-471)GCG>GTG	p.A157V	ULK2_uc002gwn.2_Missense_Mutation_p.A157V	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	157	Protein kinase.				signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					ACCAAAATCCGCTATTTCACA	0.413													8	22					0	0	0	0	A	19748690	A	A	19748690	3	1	201	1	0	0	0	0	1	0	0	0	17044	1101	38	1	2724	1	ULK2	17	19748690	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	2686854	19748690	61446520	203	36982											
GAS2L2	246176	broad.mit.edu	37	chr17	34072759	34072759	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagggcagaggtgtgtacCgcccctcctgctcctgtagg	6	8	13	14	1	0	1	0	0	0	1	2	1	2	1	6	3	2	4	6	3	3	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:34072759C>T	uc002hjv.1	-	6	1785	c.1757G>A	c.(1756-1758)CGG>CAG	p.R586Q		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	586					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGTGTGTACCGCCCCTCCTG	0.582													20	90					0	0	0	0	T	34072759	T	T	34072759	3	4	201	1	0	0	0	0	1	0	0	0	6282	652	23	1	889	1	GAS2L2	17	34072759	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	14324069	34072759	47122451	204	36983											
PTRF	284119	broad.mit.edu	37	chr17	40557194	40557194	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttcttgaagtcgtccacGcgccgcaggccgctgcgctt	4	9	12	16	6	1	1	0	1	1	0	3	1	2	1	4	1	1	3	4	1	1	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:40557194G>A	uc002hzo.2	-	2	843	c.684C>T	c.(682-684)CGC>CGT	p.R228R	PTRF_uc010wgi.1_Silent_p.R210R	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	228	Potential.				regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		AGTCGTCCACGCGCCGCAGGC	0.612													27	111					0	0	0	0	A	40557194	A	A	40557194	2	1	201	1	0	0	0	0	0	0	0	1	12880	1074	38	1		1	PTRF	17	40557194	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	6484435	40557194	40638016	205	36984											
WNK4	65266	broad.mit.edu	37	chr17	40940726	40940726	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagaatgacagagtggttGagtgccagctacagacccat	13	7	11	10	0	0	5	0	2	0	3	0	5	0	5	3	1	3	2	3	1	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:40940726G>C	uc002ibj.2	+	11	2089	c.2068G>C	c.(2068-2070)GAG>CAG	p.E690Q	WNK4_uc010wgx.1_Missense_Mutation_p.E354Q|WNK4_uc002ibk.1_Missense_Mutation_p.E462Q|WNK4_uc010wgy.1_Missense_Mutation_p.E34Q	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	690					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CAGAGTGGTTGAGTGCCAGCT	0.542													14	43					0	0	0	0	C	40940726	C	C	40940726	3	2	201	1	0	0	0	0	1	0	0	0	17448	1291	45	2	2110	2	WNK4	17	40940726	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	383532	40940726	40254484	206	36985											
LRRC37A	9884	broad.mit.edu	37	chr17	44408455	44408455	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctaccacaggtgagagacaGatcgaaagacttaacccacg	15	5	9	12	2	0	4	0	1	0	3	1	6	0	4	3	1	2	0	3	1	3	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:44408455G>C	uc002ikg.2	+	9	3815	c.3812G>C	c.(3811-3813)AGA>ACA	p.R1271T	ARL17A_uc002iki.3_Intron|ARL17A_uc002ikh.3_Intron|ARL17B_uc002ikf.2_Intron|LRRC37A_uc002ikj.2_Missense_Mutation_p.R232T|LRRC37A_uc010daw.1_Missense_Mutation_p.R201T	NM_014834	NP_055649	A6NMS7	L37A1_HUMAN	leucine rich repeat containing 37A precursor	1271	Extracellular (Potential).					integral to membrane					0		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		GTGAGAGACAGATCGAAAGAC	0.468													16	54					0	0	0	0	C	44408455	C	C	44408455	3	2	201	1	0	0	0	0	1	0	0	0	9041	942	33	2	3846	2	LRRC37A	17	44408455	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	3467729	44408455	36786755	207	36986											
SMARCD2	6603	broad.mit.edu	37	chr17	61910724	61910724	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggggtcggtgctaaaactGagcatgaaatctctctgggt	9	11	14	7	1	2	2	0	2	2	0	4	2	2	2	0	4	3	2	0	4	3	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:61910724G>C	uc010deb.1	-	11	1691	c.1374C>G	c.(1372-1374)CTC>CTG	p.L458L	SMARCD2_uc010wpt.1_Silent_p.L410L|SMARCD2_uc010dea.1_Silent_p.L383L|SMARCD2_uc010dec.1_Silent_p.L437L	NM_001098426	NP_001091896	Q92925	SMRD2_HUMAN	SWI/SNF-related matrix-associated	458					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex	protein binding|transcription coactivator activity				0						TGCTAAAACTGAGCATGAAAT	0.537													23	64					0	0	0	0	C	61910724	C	C	61910724	2	2	201	1	0	0	0	0	0	0	0	1	14842	1277	45	2		2	SMARCD2	17	61910724	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	17502269	61910724	19284486	208	36987											
LLGL2	3993	broad.mit.edu	37	chr17	73564865	73564865	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttctaggagtggccaattGatggtggcaccagcctgacc	8	11	12	10	0	1	2	0	2	1	0	1	3	1	3	4	4	1	1	4	4	2	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr17:73564865G>C	uc002joh.2	+	12	1421	c.1267G>C	c.(1267-1269)GAT>CAT	p.D423H	LLGL2_uc002joi.2_Missense_Mutation_p.D423H|LLGL2_uc010dgg.1_Missense_Mutation_p.D423H|LLGL2_uc002joj.2_Missense_Mutation_p.D412H|LLGL2_uc010wsd.1_Missense_Mutation_p.D50H	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	423	WD 8.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			GTGGCCAATTGATGGTGGCAC	0.597													6	40					0	0	0	0	C	73564865	C	C	73564865	3	2	201	1	0	0	0	0	1	0	0	0	8876	1290	45	2	1344	2	LLGL2	17	73564865	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	11654141	73564865	7630345	209	36988											
ANKRD12	23253	broad.mit.edu	37	chr18	9255172	9255172	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagtccaacatttgaaaattCagattgcacactgaaaaaaa	19	10	5	7	0	1	3	1	2	0	1	2	3	2	3	1	0	2	1	1	0	7	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr18:9255172C>T	uc002knv.2	+	9	2164	c.1907C>T	c.(1906-1908)TCA>TTA	p.S636L	ANKRD12_uc002knw.2_Missense_Mutation_p.S613L|ANKRD12_uc002knx.2_Missense_Mutation_p.S613L|ANKRD12_uc010dkx.1_Missense_Mutation_p.S343L	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	636						nucleus				ovary(2)|central_nervous_system(1)	3						TTTGAAAATTcagattgcaca	0.144													14	51					0	0	0	0	T	9255172	T	T	9255172	3	4	201	1	0	0	0	0	1	0	0	0	640	838	29	2	1937	2	ANKRD12	18	9255172	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08		9255172	68822076	210	36989											
GNAL	2774	broad.mit.edu	37	chr18	11752499	11752499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgatgaaaaagaacgacgcGaggccaacaaaaagatcgag	19	3	11	8	5	0	3	0	1	0	2	2	7	0	3	1	1	2	0	1	1	6	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr18:11752499G>A	uc010dkz.2	+	2	313	c.67G>A	c.(67-69)GAG>AAG	p.E23K	GNAL_uc002kqc.2_Intron|GNAL_uc002kqd.2_Missense_Mutation_p.E23K	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	23					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						AGAACGACGCGAGGCCAACAA	0.612													18	71					0	0	0	0	A	11752499	A	A	11752499	3	1	201	1	0	0	0	0	1	0	0	0	6544	1059	37	1	449	1	GNAL	18	11752499	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	2497327	11752499	66324749	211	36990											
SYT4	6860	broad.mit.edu	37	chr18	40853923	40853923	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtattctaaggagaagaaGagagttcccagcttctcttg	11	13	10	7	0	2	3	0	0	2	3	4	5	3	3	1	1	1	3	1	1	4	7			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr18:40853923G>C	uc002law.2	-	2	840	c.471C>G	c.(469-471)CTC>CTG	p.L157L	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Silent_p.L139L|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	157	Phospholipid binding (Probable).|C2 1.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						AGGAGAAGAAGAGAGTTCCCA	0.453													5	33					0	0	0	0	C	40853923	C	C	40853923	2	2	201	1	0	0	0	0	0	0	0	1	15542	929	33	2		2	SYT4	18	40853923	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	29101424	40853923	37223325	212	36991											
ZBTB7C	201501	broad.mit.edu	37	chr18	45566526	45566526	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggtcccagaggcccccccGgcaggtcagggaacatgtcc	7	5	14	15	1	1	1	1	0	0	1	3	2	3	2	5	5	1	1	5	5	1	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr18:45566526G>A	uc002lda.2	-	1	969	c.953C>T	c.(952-954)CCG>CTG	p.P318L	ZBTB7C_uc002ldb.2_Missense_Mutation_p.P318L|ZBTB7C_uc010dnu.2_Missense_Mutation_p.P327L|ZBTB7C_uc010dnv.2_Missense_Mutation_p.P340L|ZBTB7C_uc010dnw.2_Missense_Mutation_p.P318L|ZBTB7C_uc010dnx.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dny.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dnz.1_Missense_Mutation_p.P340L|ZBTB7C_uc010dob.1_Missense_Mutation_p.P318L|ZBTB7C_uc010doc.1_Missense_Mutation_p.P327L|ZBTB7C_uc010dod.1_Missense_Mutation_p.P340L|ZBTB7C_uc010doe.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dof.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dog.1_Missense_Mutation_p.P318L|ZBTB7C_uc010doh.1_Missense_Mutation_p.P327L|ZBTB7C_uc010doi.1_Missense_Mutation_p.P318L|ZBTB7C_uc010doj.1_Missense_Mutation_p.P327L|ZBTB7C_uc010dok.1_Missense_Mutation_p.P367L|ZBTB7C_uc010dol.1_Missense_Mutation_p.P327L|ZBTB7C_uc010doa.1_Missense_Mutation_p.P340L|ZBTB7C_uc010don.1_Missense_Mutation_p.P326L|ZBTB7C_uc010doo.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dop.1_Missense_Mutation_p.P318L|ZBTB7C_uc010doq.1_Missense_Mutation_p.P327L|ZBTB7C_uc010dor.1_Missense_Mutation_p.P340L|ZBTB7C_uc010dos.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dot.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dou.1_Missense_Mutation_p.P327L|ZBTB7C_uc010dom.1_Missense_Mutation_p.P327L	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	318	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AGGCCCCCCCGGCAGGTCAGG	0.617													4	61					0	0	0	0	A	45566526	A	A	45566526	3	1	201	1	0	0	0	0	1	0	0	0	17622	1116	39	1	914	1	ZBTB7C	18	45566526	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	4712603	45566526	32510722	213	36992											
GRP	2922	broad.mit.edu	37	chr18	56897646	56897646	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttcttaagttggtagactCtctgctccaggttctcaacg	8	15	8	10	1	3	1	1	0	3	1	6	1	4	1	1	2	2	4	1	2	3	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr18:56897646C>G	uc002lhv.2	+	3	491	c.393C>G	c.(391-393)CTC>CTG	p.L131L	GRP_uc002lhu.2_Missense_Mutation_p.S125C|GRP_uc002lhw.2_Intron	NM_002091	NP_002082	P07492	GRP_HUMAN	gastrin-releasing peptide isoform 1	131					neuropeptide signaling pathway	extracellular space	neuropeptide hormone activity				0		Colorectal(73;0.0946)				TTGGTAGACTCTCTGCTCCAG	0.393													13	59					0	0	0	0	G	56897646	G	G	56897646	2	3	201	1	0	0	0	0	0	0	0	1	6844	913	32	2		2	GRP	18	56897646	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	11331120	56897646	21179602	214	36993											
DNMT1	1786	broad.mit.edu	37	chr19	10254621	10254621	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtacaggtcctcatccacGggctccttccgtgggcgttt	4	11	13	13	3	1	0	1	0	0	0	5	0	5	0	4	4	1	3	4	4	1	3	rs150359172	by1000genomes	TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:10254621G>A	uc002mng.2	-	28	3069	c.2889C>T	c.(2887-2889)CCC>CCT	p.P963P	DNMT1_uc002mnf.2_5'UTR|DNMT1_uc010xlc.1_Silent_p.P979P|DNMT1_uc002mnh.2_Silent_p.P858P|DNMT1_uc010xld.1_Silent_p.P963P	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	963					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CCTCATCCACGGGCTCCTTCC	0.562													25	141					0	0	0	0	A	10254621	A	A	10254621	2	1	201	1	0	0	0	0	0	0	0	1	4697	1103	39	1		1	DNMT1	19	10254621	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08		10254621	48874362	215	36994											
LDLR	3949	broad.mit.edu	37	chr19	11213447	11213447	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggactgcgacaacggctcaGacgagcaaggctgtcgtaag	11	6	14	10	4	1	1	1	0	0	1	2	4	1	2	0	3	3	4	0	3	3	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:11213447G>C	uc002mqk.3	+	3	466	c.298G>C	c.(298-300)GAC>CAC	p.D100H	LDLR_uc010xlk.1_Missense_Mutation_p.D100H|LDLR_uc010xll.1_Intron|LDLR_uc010xlm.1_Intron|LDLR_uc010xln.1_Missense_Mutation_p.D100H|LDLR_uc010xlo.1_Missense_Mutation_p.D100H	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	100	Extracellular (Potential).|LDL-receptor class A 2.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CAACGGCTCAGACGAGCAAGG	0.592													14	85					0	0	0	0	C	11213447	C	C	11213447	3	2	201	1	0	0	0	0	1	0	0	0	8744	942	33	2	308	2	LDLR	19	11213447	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	958826	11213447	47915536	216	36995											
MAN2B1	4125	broad.mit.edu	37	chr19	12776262	12776262	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccacgtaaatgaagcgacGggtgggatctgccagcaagg	11	6	14	10	3	1	1	0	1	1	0	2	3	2	2	2	3	3	2	2	3	4	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:12776262G>A	uc002mub.2	-	3	416	c.340C>T	c.(340-342)CGT>TGT	p.R114C	MAN2B1_uc010dyv.1_Missense_Mutation_p.R114C|WDR83_uc002mue.3_5'Flank|WDR83_uc002muc.2_5'Flank	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	114					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						ATGAAGCGACGGGTGGGATCT	0.557													25	93					0	0	0	0	A	12776262	A	A	12776262	3	1	201	1	0	0	0	0	1	0	0	0	9269	1116	39	1	2783	1	MAN2B1	19	12776262	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1562815	12776262	46352721	217	36996											
SLC1A6	6511	broad.mit.edu	37	chr19	15061151	15061151	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgagacaagtgctcgatgacGgccgctccaattgagtcccc	9	8	11	13	3	0	3	0	3	0	1	3	5	2	3	4	1	1	2	4	1	2	1	rs143528996		TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:15061151G>T	uc002naa.1	-	9	1559	c.1551C>A	c.(1549-1551)GCC>GCA	p.A517A	SLC1A6_uc010dzu.1_Silent_p.A439A|SLC1A6_uc010xod.1_Silent_p.A453A	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	517					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	GCTCGATGACGGCCGCTCCAA	0.567													16	49					3.45872e-05	5.11652e-05	1	0	T	15061151	T	T	15061151	2	4	201	1	0	0	0	0	0	0	0	1	14501	1103	39	3		3	SLC1A6	19	15061151	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	2284889	15061151	44067832	218	36997											
ZNF430	80264	broad.mit.edu	37	chr19	21240040	21240040	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaccttactacacataaaaGaattcatactggagagaaac	19	8	5	9	0	1	2	1	0	0	2	1	4	1	3	1	1	4	0	1	1	7	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:21240040G>C	uc002npj.2	+	5	1036	c.926G>C	c.(925-927)AGA>ACA	p.R309T	ZNF430_uc002npk.2_Missense_Mutation_p.R308T	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	309	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						ACACATAAAAGAATTCATACT	0.398													21	75					0	0	0	0	C	21240040	C	C	21240040	3	2	201	1	0	0	0	0	1	0	0	0	17971	942	33	2	944	2	ZNF430	19	21240040	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	6178889	21240040	37888943	219	36998											
ZNF714	148206	broad.mit.edu	37	chr19	21300910	21300910	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catactggagagaaatcttaCaaatgtgaagaatgtggtaa	17	10	10	4	0	1	3	0	1	1	2	1	5	1	4	0	2	2	1	0	2	7	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:21300910C>G	uc002npo.3	+	6	1803	c.1443C>G	c.(1441-1443)TAC>TAG	p.Y481*	ZNF714_uc002npl.2_Nonsense_Mutation_p.Y326*|ZNF714_uc010ecp.1_Nonsense_Mutation_p.Y432*|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	481	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGAAATCTTACAAATGTGAAG	0.294													10	35					0	0	0	0	G	21300910	G	G	21300910	4	3	201	1	0	0	0	0	0	1	0	0	18185	489	17	4	1450	4	ZNF714	19	21300910	Nonsense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	60870	21300910	37828073	220	36999											
ZNF676	163223	broad.mit.edu	37	chr19	22363886	22363886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	attaccttatgtttagtaagGattgagaacttactaaaggc	14	14	8	5	0	0	1	0	1	0	1	0	3	0	2	1	2	3	2	1	2	8	8			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:22363886G>C	uc002nqs.1	-	3	951	c.633C>G	c.(631-633)ATC>ATG	p.I211M		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	211	C2H2-type 2.			KFSILTKHKVIHT -> WSSSLTEHKRIHA (in Ref. 2; BAC05174).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GTTTAGTAAGGATTGAGAACT	0.353													14	78					0	0	0	0	C	22363886	C	C	22363886	3	2	201	1	0	0	0	0	1	0	0	0	18150	1164	41	2	1137	2	ZNF676	19	22363886	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	1062976	22363886	36765097	221	37000											
ZNF536	9745	broad.mit.edu	37	chr19	30935952	30935952	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgggatgcctcaatctcGtgccgccgctgaaatccagc	7	9	10	15	3	2	1	1	1	1	0	5	2	4	2	5	1	3	1	5	1	2	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:30935952G>A	uc002nsu.1	+	2	1621	c.1483G>A	c.(1483-1485)GTG>ATG	p.V495M	ZNF536_uc010edd.1_Missense_Mutation_p.V495M	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	495					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCTCAATCTCGTGCCGCCGCT	0.657													18	66					0	0	0	0	A	30935952	A	A	30935952	3	1	201	1	0	0	0	0	1	0	0	0	18041	1145	40	1	1485	1	ZNF536	19	30935952	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	8572066	30935952	28193031	222	37001											
FBXO46	23403	broad.mit.edu	37	chr19	46215504	46215504	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtggctccgggggcccgTccggcccgcggttctggaga	2	6	20	13	5	1	1	0	0	1	1	3	2	3	1	4	8	0	2	4	8	0	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:46215504T>C	uc002pcy.2	-	2	1375	c.1250A>G	c.(1249-1251)GAC>GGC	p.D417G	FBXO46_uc002pcz.2_Missense_Mutation_p.D417G	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	417							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		CGGGGGCCCGTCCGGCCCGCG	0.726													10	22					0	0	0	0	C	46215504	C	C	46215504	3	2	201	1	0	0	0	0	1	0	0	0	5787	1667	58	5	565	5	FBXO46	19	46215504	Missense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08	15279552	46215504	12913479	223	37002											
IL4I1	259307	broad.mit.edu	37	chr19	50393181	50393181	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccagccgtgcgggtaggCggtgtgctcgccggcaaagt	6	6	16	13	5	0	0	0	0	0	0	1	0	0	0	3	4	3	3	3	4	2	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:50393181C>T	uc002pqt.1	-	8	1528	c.1450G>A	c.(1450-1452)GCC>ACC	p.A484T	IL4I1_uc002pqv.1_Missense_Mutation_p.A493T|IL4I1_uc010eno.1_Missense_Mutation_p.A492T|IL4I1_uc002pqw.1_Missense_Mutation_p.A492T|IL4I1_uc002pqu.1_Missense_Mutation_p.A506T	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	484						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		TGCGGGTAGGCGGTGTGCTCG	0.667											OREG0025629	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	18					0	0	0	0	T	50393181	T	T	50393181	3	4	201	1	0	0	0	0	1	0	0	0	7736	768	27	1	257	1	IL4I1	19	50393181	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	4177677	50393181	8735802	224	37003											
NAPSA	9476	broad.mit.edu	37	chr19	50862816	50862816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcagggcccggatctcctCagtgggtcctgtgatgaggg	6	9	16	10	1	2	2	1	2	1	0	4	3	3	3	3	4	1	1	3	4	0	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:50862816C>T	uc002prx.2	-	7	933	c.880G>A	c.(880-882)GAG>AAG	p.E294K	NR1H2_uc002prv.3_Intron	NM_004851	NP_004842	O96009	NAPSA_HUMAN	napsin A preproprotein	294					proteolysis	extracellular region	aspartic-type endopeptidase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		CGGATCTCCTCAGTGGGTCCT	0.647													14	51					0	0	0	0	T	50862816	T	T	50862816	3	4	201	1	0	0	0	0	1	0	0	0	10219	835	29	2	394	2	NAPSA	19	50862816	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	469635	50862816	8266167	225	37004											
NLRP12	91662	broad.mit.edu	37	chr19	54318203	54318203	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacttccagaaggcatgttGactggttcccaagtgaggac	11	9	12	9	0	0	4	0	2	0	2	2	5	2	5	2	3	0	3	2	3	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:54318203G>A	uc002qch.3	-	2	549	c.329C>T	c.(328-330)TCA>TTA	p.S110L	NLRP12_uc002qci.3_Missense_Mutation_p.S110L|NLRP12_uc002qcj.3_Missense_Mutation_p.S110L|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.S110L	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	110					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AAGGCATGTTGACTGGTTCCC	0.517													26	78					0	0	0	0	A	54318203	A	A	54318203	3	1	201	1	0	0	0	0	1	0	0	0	10528	1294	45	2	2988	2	NLRP12	19	54318203	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	3455387	54318203	4810780	226	37005											
ZSCAN5B	342933	broad.mit.edu	37	chr19	56701579	56701579	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctcctgtggatgcttagctGggaaaaatacttaaatgatt	12	13	9	7	0	0	1	0	1	0	0	1	3	1	3	2	2	3	2	2	2	6	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:56701579G>T	uc010ygh.1	-	4	1105	c.1105C>A	c.(1105-1107)CAG>AAG	p.Q369K		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	369	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						ATGCTTAGCTGGGAAAAATAC	0.547													19	54					6.49762e-13	1.05586e-12	1	0	T	56701579	T	T	56701579	3	4	201	1	0	0	0	0	1	0	0	0	18306	1357	47	4	386	4	ZSCAN5B	19	56701579	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	2383376	56701579	2427404	227	37006											
AURKC	6795	broad.mit.edu	37	chr19	57746747	57746747	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggttcaggcccactccCgaagggtgctgcctccctgt	4	9	12	16	1	1	0	1	0	0	0	3	1	3	0	5	3	2	2	5	3	1	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr19:57746747C>T	uc002qoe.2	+	7	1081	c.892C>T	c.(892-894)CGA>TGA	p.R298*	AURKC_uc002qoc.2_Nonsense_Mutation_p.R279*|AURKC_uc002qod.2_Nonsense_Mutation_p.R264*|AURKC_uc010etv.2_Nonsense_Mutation_p.R295*	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	298					cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		GGCCCACTCCCGAAGGGTGCT	0.622													21	75					0	0	0	0	T	57746747	T	T	57746747	4	4	201	1	0	0	0	0	0	1	0	0	1226	644	23	1	923	1	AURKC	19	57746747	Nonsense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1045168	57746747	1382236	228	37007											
PLCB1	23236	broad.mit.edu	37	chr20	8717816	8717816	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgaatcctgtctgggaaGaagaacctattgtgttcaaa	12	12	10	7	0	2	3	1	1	1	2	3	4	3	4	2	1	1	1	2	1	6	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr20:8717816G>A	uc002wnb.2	+	20	2188	c.2185G>A	c.(2185-2187)GAA>AAA	p.E729K	PLCB1_uc010zrb.1_Missense_Mutation_p.E628K|PLCB1_uc002wna.2_Missense_Mutation_p.E729K|PLCB1_uc002wnc.1_Missense_Mutation_p.E628K|PLCB1_uc002wnd.1_Missense_Mutation_p.E306K	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	729	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TGTCTGGGAAGAAGAACCTAT	0.378													6	42					0	0	0	0	A	8717816	A	A	8717816	3	1	201	1	0	0	0	0	1	0	0	0	12082	943	33	2	2263	2	PLCB1	20	8717816	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08		8717816	54307704	229	37008											
SLC12A5	57468	broad.mit.edu	37	chr20	44675031	44675031	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcctgtgcagtgcagacgctGctgaggacacccaactggag	9	6	14	12	1	0	2	0	1	0	1	0	4	0	4	2	2	4	4	2	2	1	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr20:44675031G>T	uc010zxl.1	+	14	1888	c.1812G>T	c.(1810-1812)CTG>CTT	p.L604L	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Silent_p.L581L	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	604	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGCAGACGCTGCTGAGGACAC	0.567													14	65					6.72482e-11	1.07247e-10	1	0	T	44675031	T	T	44675031	2	4	201	1	0	0	0	0	0	0	0	1	14451	1306	46	4		4	SLC12A5	20	44675031	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	35957215	44675031	18350489	230	37009											
ZFP64	55734	broad.mit.edu	37	chr20	50701128	50701128	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgggctctaggggagcctCgagctgccccacggagacca	7	5	15	14	2	1	1	0	0	1	1	2	4	1	2	4	4	3	3	4	4	1	1	rs142930891	byFrequency	TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr20:50701128C>T	uc002xwk.2	-	9	2255	c.1906G>A	c.(1906-1908)GAG>AAG	p.E636K	ZFP64_uc002xwj.2_Missense_Mutation_p.E417K	NM_199427	NP_955459	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform d	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						AGGGGAGCCTCGAGCTGCCCC	0.612													11	30					0	0	0	0	T	50701128	T	T	50701128	3	4	201	1	0	0	0	0	1	0	0	0	17719	893	31	1	35	1	ZFP64	20	50701128	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	6026097	50701128	12324392	231	37010											
BMP7	655	broad.mit.edu	37	chr20	55750064	55750064	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtcgctgctgctgttctCtgcattgacaaggaagtgaa	8	12	12	9	1	1	2	0	2	1	0	3	3	1	3	0	2	3	5	0	2	3	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr20:55750064C>G	uc010gip.1	-	5	1488	c.959_splice	c.e5-1	p.E320_splice	BMP7_uc010giq.1_Splice_Site_p.E254_splice|BMP7_uc002xyc.2_Splice_Site_p.E320_splice	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor						BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			CTGCTGTTCTCTGCATTGACA	0.537													4	6					0	0	0	0	G	55750064	G	G	55750064	5	3	201	1	0	0	0	0	0	0	1	0	1468	927	32	2	349	2	BMP7	20	55750064	Splice_Site	SNP	C	TCGA-CV-6942-01A-21D-2012-08	5048936	55750064	7275456	232	37011											
PHACTR3	116154	broad.mit.edu	37	chr20	58349449	58349449	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaactgccgctaaggaatctGaggagaacaaggagaacctg	15	5	13	8	1	1	3	0	1	1	2	1	7	1	4	2	3	4	1	2	3	6	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr20:58349449G>T	uc002yau.2	+	7	1545	c.1078G>T	c.(1078-1080)GAG>TAG	p.E360*	PHACTR3_uc002yat.2_Nonsense_Mutation_p.E357*|PHACTR3_uc010zzw.1_Nonsense_Mutation_p.E319*|PHACTR3_uc002yav.2_Nonsense_Mutation_p.E319*|PHACTR3_uc002yaw.2_Nonsense_Mutation_p.E319*|PHACTR3_uc002yax.2_Nonsense_Mutation_p.E249*	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	360	Potential.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			TAAGGAATCTGAGGAGAACAA	0.517													22	70					8.10497e-08	1.2418e-07	1	0	T	58349449	T	T	58349449	4	4	201	1	0	0	0	0	0	1	0	0	11866	1291	45	2	1104	2	PHACTR3	20	58349449	Nonsense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	2599385	58349449	4676071	233	37012											
KCNQ2	3785	broad.mit.edu	37	chr20	62039880	62039880	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgggccccgccccacgatCtggtccactctaccgggaac	6	6	11	18	3	2	0	0	0	2	0	3	2	3	1	6	3	2	1	6	3	2	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr20:62039880C>G	uc002yey.1	-	16	1950	c.1773G>C	c.(1771-1773)CAG>CAC	p.Q591H	KCNQ2_uc002yez.1_Missense_Mutation_p.Q560H|KCNQ2_uc002yfa.1_Missense_Mutation_p.Q573H|KCNQ2_uc002yfb.1_Missense_Mutation_p.Q563H	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	591	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GCCCCACGATCTGGTCCACTC	0.697													3	18					0	0	0	0	G	62039880	G	G	62039880	3	3	201	1	0	0	0	0	1	0	0	0	8122	912	32	2	853	2	KCNQ2	20	62039880	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	3690431	62039880	985640	234	37013											
BAGE2	85319	broad.mit.edu	37	chr21	11049621	11049621	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacagtttgcatcttccttcGctataattaacagtaaaaca	14	13	4	10	1	1	0	0	0	1	0	3	0	2	0	1	0	3	4	1	0	5	7	rs28441174		TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr21:11049621G>A	uc002yit.1	-	4	488	c.280C>T	c.(280-282)CGA>TGA	p.R94*		NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATCTTCCTTCGCTATAATTAA	0.368													22	144					0	0	0	0	A	11049621	A	A	11049621	4	1	201	1	0	0	0	0	0	1	0	0	1294	1101	38	1	53	1	BAGE2	21	11049621	Nonsense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08		11049621	37080274	235	37014											
NCAM2	4685	broad.mit.edu	37	chr21	22710789	22710789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcgtatgtgatgcggaagggGagcctattccagaaatcact	11	10	12	8	2	1	2	1	1	0	1	3	4	2	4	2	3	2	1	2	3	4	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr21:22710789G>A	uc002yld.1	+	8	1228	c.979G>A	c.(979-981)GAG>AAG	p.E327K	NCAM2_uc011acb.1_Missense_Mutation_p.E185K|NCAM2_uc011acc.1_Missense_Mutation_p.E352K	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	327	Ig-like C2-type 4.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TGCGGAAGGGGAGCCTATTCC	0.388													8	16					0	0	0	0	A	22710789	A	A	22710789	3	1	201	1	0	0	0	0	1	0	0	0	10257	1175	41	2	1009	2	NCAM2	21	22710789	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	11661168	22710789	25419106	236	37015											
SYNJ1	8867	broad.mit.edu	37	chr21	34037326	34037326	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttcgttagggagatcgattCgatagttgaaatcaccacac	12	11	9	9	3	1	2	1	1	0	1	4	5	1	2	1	1	0	2	1	1	3	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr21:34037326C>T	uc002yqh.2	-	18	2318	c.2318G>A	c.(2317-2319)CGA>CAA	p.R773Q	SYNJ1_uc011ads.1_Missense_Mutation_p.R729Q|SYNJ1_uc002yqf.2_Missense_Mutation_p.R734Q|SYNJ1_uc002yqg.2_Missense_Mutation_p.R729Q|SYNJ1_uc002yqi.2_Missense_Mutation_p.R773Q	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	734	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						GAGATCGATTCGATAGTTGAA	0.348													7	44					0	0	0	0	T	34037326	T	T	34037326	3	4	201	1	0	0	0	0	1	0	0	0	15518	884	31	1	2605	1	SYNJ1	21	34037326	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	11326537	34037326	14092569	237	37016											
MX1	4599	broad.mit.edu	37	chr21	42824567	42824567	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccaaaattgaagacattaGagcagaacaagagagagaag	20	5	11	5	0	0	6	0	1	0	5	1	8	1	6	1	0	2	1	1	0	7	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr21:42824567G>C	uc002yzh.2	+	18	2476	c.1529G>C	c.(1528-1530)AGA>ACA	p.R510T	MX1_uc002yzi.2_Missense_Mutation_p.R510T|MX1_uc010goq.2_Missense_Mutation_p.R510T	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	510					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GAAGACATTAGAGCAGAACAA	0.428													17	71					0	0	0	0	C	42824567	C	C	42824567	3	2	201	1	0	0	0	0	1	0	0	0	10050	942	33	2	1575	2	MX1	21	42824567	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	8787241	42824567	5305328	238	37017											
RIPK4	54101	broad.mit.edu	37	chr21	43161791	43161791	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttcttctccaacagcagcCgtgtgctagactcgtccccg	6	10	9	16	4	2	1	0	0	2	1	5	1	3	1	4	0	4	3	4	0	2	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr21:43161791C>T	uc002yzn.1	-	8	1610	c.1562G>A	c.(1561-1563)CGG>CAG	p.R521Q		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	521						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						CAACAGCAGCCGTGTGCTAGA	0.627													9	44					0	0	0	0	T	43161791	T	T	43161791	3	4	201	1	0	0	0	0	1	0	0	0	13448	652	23	1	796	1	RIPK4	21	43161791	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	337224	43161791	4968104	239	37018											
UMODL1	89766	broad.mit.edu	37	chr21	43531075	43531075	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcacgggaacagcagccctCggcctagagaacttcacctt	10	6	11	14	2	1	1	1	0	0	1	2	3	1	2	3	3	4	2	3	3	3	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr21:43531075C>T	uc002zaf.1	+	11	1743	c.1743C>T	c.(1741-1743)CTC>CTT	p.L581L	UMODL1_uc002zad.1_Silent_p.L509L|UMODL1_uc002zae.1_Silent_p.L509L|UMODL1_uc002zag.1_Silent_p.L581L|C21orf128_uc002zak.2_5'Flank	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	581	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CAGCAGCCCTCGGCCTAGAGA	0.657													12	32					0	0	0	0	T	43531075	T	T	43531075	2	4	201	1	0	0	0	0	0	0	0	1	17048	871	31	1		1	UMODL1	21	43531075	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	369284	43531075	4598820	240	37019											
MCM3AP	8888	broad.mit.edu	37	chr21	47665030	47665030	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcatggccaatcccgtcttCgacgtactgaatgagagtct	9	11	9	12	3	3	2	1	2	2	1	5	4	4	2	2	1	1	1	2	1	3	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr21:47665030C>T	uc002zir.1	-	23	4765	c.4729G>A	c.(4729-4731)GAA>AAA	p.E1577K	MCM3APAS_uc002zim.2_Intron|MCM3APAS_uc002zin.2_Intron|MCM3AP_uc002zio.1_Missense_Mutation_p.E72K|MCM3AP_uc002zip.1_Missense_Mutation_p.E318K|MCM3AP_uc002ziq.1_Missense_Mutation_p.E504K|MCM3APAS_uc002zis.1_Intron	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	1577					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					ATCCCGTCTTCGACGTACTGA	0.542													16	56					0	0	0	0	T	47665030	T	T	47665030	3	4	201	1	0	0	0	0	1	0	0	0	9441	893	31	1	1237	1	MCM3AP	21	47665030	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	4133955	47665030	464865	241	37020											
XKR3	150165	broad.mit.edu	37	chr22	17288845	17288845	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccacagtagagaacagttGagaagataatgctaaaagga	19	6	10	6	0	0	3	0	1	0	3	0	6	0	4	1	1	2	3	1	1	6	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr22:17288845G>C	uc002zlv.2	-	2	217	c.119C>G	c.(118-120)TCA>TGA	p.S40*	XKR3_uc011agf.1_Nonsense_Mutation_p.S40*	NM_175878	NP_787074	Q5GH77	XKR3_HUMAN	X Kell blood group precursor-related family,	40	Helical; (Potential).					integral to membrane|plasma membrane				large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GAGAACAGTTGAGAAGATAAT	0.388													15	59					0	0	0	0	C	17288845	C	C	17288845	4	2	201	1	0	0	0	0	0	1	0	0	17500	1294	45	2	1272	2	XKR3	22	17288845	Nonsense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08		17288845	34015721	242	37021											
LIF	3976	broad.mit.edu	37	chr22	30639779	30639779	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catggcccacgtggtacttgCtgcacaggcggcacagcacg	8	6	13	14	3	0	0	0	0	0	0	0	0	0	0	1	4	4	5	1	4	1	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr22:30639779C>A	uc003agz.2	-	3	582	c.470G>T	c.(469-471)AGC>ATC	p.S157I	LIF_uc011aks.1_3'UTR|uc003aha.2_5'Flank	NM_002309	NP_002300	P15018	LIF_HUMAN	leukemia inhibitory factor (cholinergic	157					immune response|leukemia inhibitory factor signaling pathway|negative regulation of hormone secretion|positive regulation of cell proliferation|positive regulation of macrophage differentiation|positive regulation of MAPKKK cascade|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of metanephric nephron tubule epithelial cell differentiation		cytokine activity|growth factor activity|leukemia inhibitory factor receptor binding				0			Epithelial(10;0.171)			GTGGTACTTGCTGCACAGGCG	0.607													24	59					1.17739e-12	1.90604e-12	1	0	A	30639779	A	A	30639779	3	1	201	1	0	0	0	0	1	0	0	0	8820	797	28	4	142	4	LIF	22	30639779	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	13350934	30639779	20664787	243	37022											
CSNK1E	1454	broad.mit.edu	37	chr22	38690154	38690154	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagacctcttgccgcccagtGaggtctgaggaggagacgtt	8	8	15	10	2	2	4	0	2	2	2	2	7	2	5	3	3	1	1	3	3	0	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr22:38690154G>A	uc003avj.2	-	9	1440	c.1179C>T	c.(1177-1179)CTC>CTT	p.L393L	CSNK1E_uc003avk.2_Silent_p.L393L|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Silent_p.L393L|CSNK1E_uc003avn.1_Silent_p.L77L|CSNK1E_uc003avo.2_Silent_p.L393L	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	393					DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)					GCCGCCCAGTGAGGTCTGAGG	0.647													6	38					0	0	0	0	A	38690154	A	A	38690154	2	1	201	1	0	0	0	0	0	0	0	1	3970	1277	45	2		2	CSNK1E	22	38690154	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	8050375	38690154	12614412	244	37023											
PKDREJ	10343	broad.mit.edu	37	chr22	46657509	46657509	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aataagtgcaattcctttagCtggattaattttgcattctc	11	17	6	7	0	1	0	0	0	1	0	3	1	2	1	1	1	3	3	1	1	5	8			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr22:46657509C>G	uc003bhh.2	-	1	1711	c.1711G>C	c.(1711-1713)GCT>CCT	p.A571P		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	571	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATTCCTTTAGCTGGATTAATT	0.368													7	51					0	0	0	0	G	46657509	G	G	46657509	3	3	201	1	0	0	0	0	1	0	0	0	12025	797	28	4	5054	4	PKDREJ	22	46657509	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	7967355	46657509	4647057	245	37024											
CELSR1	9620	broad.mit.edu	37	chr22	46780555	46780555	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accctggctcccgtaaagttGaacttgtcaaagatgtcgac	11	10	9	11	2	1	2	1	1	0	1	3	3	2	2	2	1	1	3	2	1	4	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chr22:46780555G>T	uc003bhw.1	-	20	6768	c.6768C>A	c.(6766-6768)TTC>TTA	p.F2256L	CELSR1_uc011arc.1_Missense_Mutation_p.F577L	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2256	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCGTAAAGTTGAACTTGTCAA	0.522													7	37					0.000274275	0.000401584	1	0	T	46780555	T	T	46780555	3	4	201	1	0	0	0	0	1	0	0	0	3236	1281	45	2	2340	2	CELSR1	22	46780555	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	123046	46780555	4524011	246	37025											
MXRA5	25878	broad.mit.edu	37	chrX	3238066	3238066	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgtggaaacctttgtcCaagtaacgaaaggctttggt	11	12	10	8	1	0	0	0	0	0	0	1	2	1	1	3	3	3	2	3	3	5	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:3238066C>A	uc004crg.3	-	5	5817	c.5660G>T	c.(5659-5661)TGG>TTG	p.W1887L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1887	Ig-like C2-type 3.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AACCTTTGTCCAAGTAACGAA	0.393													16	58					0.00074312	0.00107702	1	0	A	3238066	A	A	3238066	3	1	201	1	0	0	0	0	1	0	0	0	10056	595	21	4	2838	4	MXRA5	23	3238066	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08		3238066	152032494	247	37026											
ARHGAP6	395	broad.mit.edu	37	chrX	11197434	11197434	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacgcacagagagtgttgaTgaaagctgtgtacagctccc	11	10	11	9	1	0	3	0	2	0	1	1	4	1	3	1	0	4	5	1	0	3	3	rs147456861		TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:11197434T>C	uc004cup.1	-	7	2341	c.1468A>G	c.(1468-1470)ATC>GTC	p.I490V	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.I490V|ARHGAP6_uc004cum.1_Missense_Mutation_p.I287V|ARHGAP6_uc004cun.1_Missense_Mutation_p.I310V|ARHGAP6_uc010neb.1_Missense_Mutation_p.I312V|ARHGAP6_uc011mif.1_Missense_Mutation_p.I287V	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	490	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						AGAGTGTTGATGAAAGCTGTG	0.483													29	93					0	0	0	0	C	11197434	C	C	11197434	3	2	201	1	0	0	0	0	1	0	0	0	887	1464	51	5	1606	5	ARHGAP6	23	11197434	Missense_Mutation	SNP	T	TCGA-CV-6942-01A-21D-2012-08	7959368	11197434	144073126	248	37027											
DMD	1756	broad.mit.edu	37	chrX	32366610	32366610	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcaatttttgtatatctgaGttaaactgctccaattcctt	11	17	5	8	0	1	1	0	1	1	0	3	1	3	1	2	0	3	4	2	0	6	7			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:32366610G>T	uc004dda.1	-	38	5605	c.5361C>A	c.(5359-5361)AAC>AAA	p.N1787K	DMD_uc004dcw.2_Missense_Mutation_p.N443K|DMD_uc004dcx.2_Missense_Mutation_p.N446K|DMD_uc004dcz.2_Missense_Mutation_p.N1664K|DMD_uc004dcy.1_Missense_Mutation_p.N1783K|DMD_uc004ddb.1_Missense_Mutation_p.N1779K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1787	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GTATATCTGAGTTAAACTGCT	0.333													9	40					1.12685e-05	1.67854e-05	1	0	T	32366610	T	T	32366610	3	4	201	1	0	0	0	0	1	0	0	0	4602	1020	36	4	6012	4	DMD	23	32366610	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	21169176	32366610	122903950	249	37028											
XK	7504	broad.mit.edu	37	chrX	37586996	37586996	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaagtcaaagtgaagcctCtggcctatgtctgtatcttc	10	13	9	9	0	4	2	1	2	3	0	5	2	4	2	2	1	1	1	2	1	5	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:37586996C>T	uc004ddq.2	+	3	698	c.616C>T	c.(616-618)CTG>TTG	p.L206L		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	206	Extracellular (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				AGTGAAGCCTCTGGCCTATGT	0.493													10	39					0	0	0	0	T	37586996	T	T	37586996	2	4	201	1	0	0	0	0	0	0	0	1	17499	912	32	2		2	XK	23	37586996	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	5220386	37586996	117683564	250	37029											
ERAS	3266	broad.mit.edu	37	chrX	48687838	48687838	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagcagggcaggccatccAtagggccctgcgtgaccagt	9	5	13	14	1	0	1	0	1	0	0	1	1	1	1	4	3	2	2	4	3	1	1			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:48687838A>T	uc004dky.1	+	1	556	c.305A>T	c.(304-306)CAT>CTT	p.H102L		NM_181532	NP_853510	Q7Z444	RASE_HUMAN	ES cell expressed Ras precursor	102					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			lung(4)|urinary_tract(1)	5						CAGGCCATCCATAGGGCCCTG	0.597													20	83					0	0	0	0	T	48687838	T	T	48687838	3	4	201	1	0	0	0	0	1	0	0	0	5229	217	8	5	307	5	ERAS	23	48687838	Missense_Mutation	SNP	A	TCGA-CV-6942-01A-21D-2012-08	11100842	48687838	106582722	251	37030											
WNK3	65267	broad.mit.edu	37	chrX	54337720	54337720	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gctcagctttggttaactttCggtcctgaaaaggaataaca	12	12	9	8	1	1	1	1	1	0	0	3	2	2	2	1	3	3	3	1	3	5	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:54337720C>G	uc004dtd.1	-	3	981	c.542G>C	c.(541-543)CGA>CCA	p.R181P	WNK3_uc004dtc.1_Missense_Mutation_p.R181P	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	181	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GGTTAACTTTCGGTCCTGAAA	0.378													8	18					0	0	0	0	G	54337720	G	G	54337720	3	3	201	1	0	0	0	0	1	0	0	0	17447	884	31	3	4948	3	WNK3	23	54337720	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	5649882	54337720	100932840	252	37031											
RRAGB	10325	broad.mit.edu	37	chrX	55757890	55757890	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tatgtctttgatgtggagagCcgcgaactggaaaaggacat	12	10	13	6	2	1	2	0	1	1	1	1	6	1	4	1	3	2	0	1	3	4	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:55757890C>T	uc004dup.2	+	6	1122	c.471C>T	c.(469-471)AGC>AGT	p.S157S	RRAGB_uc004duq.2_Silent_p.S129S	NM_016656	NP_057740	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B long isoform	157					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding				0						ATGTGGAGAGCCGCGAACTGG	0.433													3	19					0	0	0	0	T	55757890	T	T	55757890	2	4	201	1	0	0	0	0	0	0	0	1	13738	738	26	4		4	RRAGB	23	55757890	Silent	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1420170	55757890	99512670	253	37032											
ACRC	93953	broad.mit.edu	37	chrX	70824232	70824232	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccagcatgattcatctgatGatgctggtgagcaggatctt	9	12	11	9	0	3	4	1	4	2	0	3	5	3	5	1	2	3	3	1	2	0	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:70824232G>A	uc004eae.2	+	8	1606	c.1105G>A	c.(1105-1107)GAT>AAT	p.D369N	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	369						nucleus				ovary(3)	3	Renal(35;0.156)					TTCATCTGATGATGCTGGTGA	0.483													11	43					0	0	0	0	A	70824232	A	A	70824232	3	1	201	1	0	0	0	0	1	0	0	0	171	1290	45	2	1131	2	ACRC	23	70824232	Missense_Mutation	SNP	G	TCGA-CV-6942-01A-21D-2012-08	15066342	70824232	84446328	254	37033											
MAGEE1	57692	broad.mit.edu	37	chrX	75649321	75649321	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggactgagcacctccgtgcCgcccaccgccactgaggagt	7	5	13	16	3	0	2	0	2	0	0	1	4	1	4	6	2	2	1	6	2	0	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:75649321C>T	uc004ecm.1	+	1	1205	c.998C>T	c.(997-999)CCG>CTG	p.P333L		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	333	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						ACCTCCGTGCCGCCCACCGCC	0.697													9	32					0	0	0	0	T	75649321	T	T	75649321	3	4	201	1	0	0	0	0	1	0	0	0	9238	652	23	1	1000	1	MAGEE1	23	75649321	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	4825089	75649321	79621239	255	37034											
ACSL4	2182	broad.mit.edu	37	chrX	108926454	108926454	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccttcttcccaaacttggAtacagcatggtcaaataatt	12	13	6	10	0	2	0	1	0	1	0	4	1	4	1	2	2	3	1	2	2	4	6			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:108926454A>T	uc004eoi.2	-	4	767	c.262T>A	c.(262-264)TCC>ACC	p.S88T	ACSL4_uc004eoj.2_Missense_Mutation_p.S47T|ACSL4_uc004eok.2_Missense_Mutation_p.S47T|ACSL4_uc010npp.1_Missense_Mutation_p.S88T	NM_022977	NP_075266	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	88	Cytoplasmic (Potential).				fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(1)|lung(1)|ovary(1)	3					Icosapent(DB00159)|Troglitazone(DB00197)	CCAAACTTGGATACAGCATGG	0.413													35	140					0	0	0	0	T	108926454	T	T	108926454	3	4	201	1	0	0	0	0	1	0	0	0	179	333	12	5	1929	5	ACSL4	23	108926454	Missense_Mutation	SNP	A	TCGA-CV-6942-01A-21D-2012-08	33277133	108926454	46344106	256	37035											
DCAF12L2	340578	broad.mit.edu	37	chrX	125299536	125299536	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatgtggcctgactgcacGtccaccacaaacagcgtatt	10	9	10	12	2	0	2	0	2	0	0	1	2	1	2	3	1	3	2	3	1	2	2			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:125299536G>A	uc004euk.1	-	1	399	c.372C>T	c.(370-372)GAC>GAT	p.D124D		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	124										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CTGACTGCACGTCCACCACAA	0.642													11	91					0	0	0	0	A	125299536	A	A	125299536	2	1	201	1	0	0	0	0	0	0	0	1	4282	1136	40	1		1	DCAF12L2	23	125299536	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	16373082	125299536	29971024	257	37036											
ZNF449	203523	broad.mit.edu	37	chrX	134493848	134493848	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaaaacttgacatgaacttCtcattggagaatagagaaga	17	9	8	7	0	1	5	1	2	1	3	2	7	1	5	1	1	2	0	1	1	6	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:134493848C>G	uc004eys.2	+	4	756	c.591C>G	c.(589-591)TTC>TTG	p.F197L	ZNF449_uc004eyt.2_Missense_Mutation_p.F77L|ZNF449_uc004eyu.2_Missense_Mutation_p.F3L	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	197					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ACATGAACTTCTCATTGGAGA	0.363													33	91					0	0	0	0	G	134493848	G	G	134493848	3	3	201	1	0	0	0	0	1	0	0	0	17987	912	32	2	601	2	ZNF449	23	134493848	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	9194312	134493848	20776712	258	37037											
ATP11C	286410	broad.mit.edu	37	chrX	138871517	138871517	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtcaaaatatgttaaagttCcatcagtttgagataatcca	15	14	6	6	0	2	1	2	1	0	1	4	2	4	1	2	0	0	3	2	0	6	5			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:138871517C>T	uc004faz.2	-	13	1445	c.1346G>A	c.(1345-1347)GGA>GAA	p.G449E	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.G449E	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	449	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TGTTAAAGTTCCATCAGTTTG	0.328													11	44					0	0	0	0	T	138871517	T	T	138871517	3	4	201	1	0	0	0	0	1	0	0	0	1123	855	30	2	2187	2	ATP11C	23	138871517	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	4377669	138871517	16399043	259	37038											
MAGEC2	51438	broad.mit.edu	37	chrX	141290746	141290746	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatcaattgtggcctggactCtctcttccacatctttcaaa	9	15	5	12	0	5	0	2	0	3	0	7	1	6	1	2	2	0	0	2	2	3	4			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:141290746C>G	uc004fbu.1	-	3	1376	c.1028G>C	c.(1027-1029)AGA>ACA	p.R343T		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	343						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCTGGACTCTCTCTTCCAC	0.453										HNSCC(46;0.14)			30	135					0	0	0	0	G	141290746	G	G	141290746	3	3	201	1	0	0	0	0	1	0	0	0	9234	913	32	2	97	2	MAGEC2	23	141290746	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	2419229	141290746	13979814	260	37039											
SLITRK4	139065	broad.mit.edu	37	chrX	142717244	142717244	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaaactgaacaggcgtctCacatttcagttctttcacaa	12	11	7	11	1	4	1	3	1	2	0	5	1	4	1	0	2	2	2	0	2	3	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:142717244C>T	uc004fbx.2	-	2	2057	c.1681G>A	c.(1681-1683)GAG>AAG	p.E561K	SLITRK4_uc004fby.2_Missense_Mutation_p.E561K	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	561	Extracellular (Potential).|LRRCT 2.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGGCGTCTCACATTTCAGT	0.458													35	123					0	0	0	0	T	142717244	T	T	142717244	3	4	201	1	0	0	0	0	1	0	0	0	14809	835	29	2	836	2	SLITRK4	23	142717244	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	1426498	142717244	12553316	261	37040											
ARHGAP4	393	broad.mit.edu	37	chrX	153178184	153178184	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctccatgtctcccccaaaGagtctctggttatactggga	8	13	8	12	0	3	1	0	0	3	1	6	2	3	2	3	2	1	1	3	2	3	3			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:153178184G>C	uc004fjk.1	-	12	1554	c.1512C>G	c.(1510-1512)CTC>CTG	p.L504L	ARHGAP4_uc004fjj.1_5'Flank|ARHGAP4_uc011mzf.1_Silent_p.L481L|ARHGAP4_uc004fjl.1_Silent_p.L544L|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	504					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTCCCCCAAAGAGTCTCTGGT	0.552													33	115					0	0	0	0	C	153178184	C	C	153178184	2	2	201	1	0	0	0	0	0	0	0	1	885	929	33	2		2	ARHGAP4	23	153178184	Silent	SNP	G	TCGA-CV-6942-01A-21D-2012-08	10460940	153178184	2092376	262	37041											
ARHGAP4	393	broad.mit.edu	37	chrX	153178994	153178994	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggaatcaagcacatcccCgtcatccgaggccaccacct	12	5	8	16	2	2	0	2	0	0	0	4	3	4	1	6	2	1	1	6	2	3	0			TCGA-CV-6942-01A-21D-2012-08	TCGA-CV-6942-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5409f12-e438-4979-b40e-120899c1fa15	b780d424-5294-4725-807c-063d6aa64adf	g.chrX:153178994C>T	uc004fjk.1	-	9	1237	c.1195G>A	c.(1195-1197)GGG>AGG	p.G399R	ARHGAP4_uc004fjj.1_5'Flank|ARHGAP4_uc011mzf.1_Missense_Mutation_p.G376R|ARHGAP4_uc004fjl.1_Missense_Mutation_p.G439R|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	399					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCACATCCCCGTCATCCGAG	0.657													25	68					0	0	0	0	T	153178994	T	T	153178994	3	4	201	1	0	0	0	0	1	0	0	0	885	652	23	1	1701	1	ARHGAP4	23	153178994	Missense_Mutation	SNP	C	TCGA-CV-6942-01A-21D-2012-08	810	153178994	2091566	263	37042											
ENO1	2023	broad.mit.edu	37	chr1	8928111	8928111	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcttgttctgtgacgttCagtttctacgagggagaggg	6	15	13	7	2	4	2	1	1	3	1	5	4	4	2	0	2	1	3	0	2	1	6			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr1:8928111C>G	uc001apj.1	-	5	397	c.246G>C	c.(244-246)CTG>CTC	p.L82L	ENO1_uc001api.1_5'UTR|ENO1_uc001apk.1_Silent_p.L27L|ENO1_uc001apl.1_Silent_p.L82L|ENO1_uc009vmi.1_Intron|ENO1_uc009vmj.1_Silent_p.L82L|ENO1_uc009vmk.1_Intron|ENO1_uc009vml.1_Silent_p.L82L	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	82					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CTGTGACGTTCAGTTTCTACG	0.473													21	304					0	0	0	0	G	8928111	G	G	8928111	2	3	202	1	0	0	0	0	0	0	0	1	5145	813	29	2		2	ENO1	1	8928111	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08		8928111	240322510	1	37043											
KIF1B	23095	broad.mit.edu	37	chr1	10357284	10357284	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaggaagaagcagatcttCttttggagcagcagagactg	14	8	13	6	0	2	4	0	0	2	4	2	7	2	6	0	2	3	3	0	2	3	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr1:10357284C>A	uc001aqx.3	+	22	2297	c.2095C>A	c.(2095-2097)CTT>ATT	p.L699I	KIF1B_uc001aqv.3_Missense_Mutation_p.L653I|KIF1B_uc001aqw.3_Missense_Mutation_p.L653I|KIF1B_uc001aqy.2_Missense_Mutation_p.L673I|KIF1B_uc001aqz.2_Missense_Mutation_p.L699I|KIF1B_uc001ara.2_Missense_Mutation_p.L659I|KIF1B_uc001arb.2_Missense_Mutation_p.L685I	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	699	Potential.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		AGCAGATCTTCTTTTGGAGCA	0.393													19	143					2.37509e-13	1.26271e-12	1	0	A	10357284	A	A	10357284	3	1	202	1	0	0	0	0	1	0	0	0	8323	913	32	2	2031	2	KIF1B	1	10357284	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	1429173	10357284	238893337	2	37044											
TCHHL1	126637	broad.mit.edu	37	chr1	152058381	152058381	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttccctgcctctgggtatCtgggttattattgtgacctc	4	17	10	10	0	2	1	0	1	2	0	4	1	3	1	3	2	1	3	3	2	3	5			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr1:152058381C>G	uc001ezo.1	-	3	1842	c.1777G>C	c.(1777-1779)GAT>CAT	p.D593H		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	593							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CTCTGGGTATCTGGGTTATTA	0.542													11	181					0	0	0	0	G	152058381	G	G	152058381	3	3	202	1	0	0	0	0	1	0	0	0	15767	913	32	2	941	2	TCHHL1	1	152058381	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	141701097	152058381	97192240	3	37045											
F13B	2165	broad.mit.edu	37	chr1	197021931	197021931	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttcatttctatgttatttCtgttcatgtaatccacatta	10	20	3	8	0	4	0	2	0	2	0	5	0	5	0	1	0	0	3	1	0	4	8			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr1:197021931C>G	uc001gtt.1	-	9	1432	c.1388G>C	c.(1387-1389)AGA>ACA	p.R463T		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	463	Sushi 8.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TATGTTATTTCTGTTCATGTA	0.279													8	71					0	0	0	0	G	197021931	G	G	197021931	3	3	202	1	0	0	0	0	1	0	0	0	5366	913	32	2	613	2	F13B	1	197021931	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	44963550	197021931	52228690	4	37046											
ATP2B4	493	broad.mit.edu	37	chr1	203652440	203652440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggaagctcatggagctgcGttcaagggatgcactgaccc	10	7	14	10	1	2	1	2	1	0	0	2	5	2	4	1	3	4	4	1	3	2	1			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr1:203652440G>A	uc001gzw.2	+	2	991	c.107G>A	c.(106-108)CGT>CAT	p.R36H	ATP2B4_uc001gzv.2_Missense_Mutation_p.R36H|ATP2B4_uc009xaq.2_Missense_Mutation_p.R36H	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	36	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATGGAGCTGCGTTCAAGGGAT	0.522													10	165					0	0	0	0	A	203652440	A	A	203652440	3	1	202	1	0	0	0	0	1	0	0	0	1144	1145	40	1	109	1	ATP2B4	1	203652440	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	6630509	203652440	45598181	5	37047											
EMILIN1	11117	broad.mit.edu	37	chr2	27306123	27306123	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttcacactacggctgaatCtcactgcggcccggctaggc	8	8	11	14	3	2	1	2	1	1	0	3	1	2	1	1	4	2	3	1	4	3	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr2:27306123C>G	uc002rii.3	+	4	2112	c.1684C>G	c.(1684-1686)CTC>GTC	p.L562V	EMILIN1_uc002rik.3_5'Flank	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	562					cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACGGCTGAATCTCACTGCGGC	0.642													7	51					0	0	0	0	G	27306123	G	G	27306123	3	3	202	1	0	0	0	0	1	0	0	0	5117	913	32	2	1698	2	EMILIN1	2	27306123	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08		27306123	215893250	6	37048											
SOS1	6654	broad.mit.edu	37	chr2	39250272	39250272	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgtccaatgtcttttccctCccaaccatcaatattcttct	8	16	2	15	0	4	0	1	0	3	0	7	0	7	0	4	0	1	0	4	0	4	5			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr2:39250272C>T	uc002rrk.3	-	10	1338	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_Missense_Mutation_p.E47K|SOS1_uc002rrl.2_Missense_Mutation_p.E165K	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	433			E -> K (in NS4).		apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.E433K(1)		ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				TCTTTTCCCTCCCAACCATCA	0.388									Noonan_syndrome				5	78					0	0	0	0	T	39250272	T	T	39250272	3	4	202	1	0	0	0	0	1	0	0	0	15000	864	30	2	2760	2	SOS1	2	39250272	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	11944149	39250272	203949101	7	37049											
RGPD4	285190	broad.mit.edu	37	chr2	108488225	108488226	+	Missense_Mutation	DNP	GG	AA	AA																															tgggataactgtgatttaagGgaagatgctttggatgatag																										TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr2:108488225_108488226GG>AA	uc010ywk.1	+	20	3847_3848	c.3765_3766GG>AA	c.(3763-3768)AGGGAA>AGAAAA	p.E1256K	RGPD4_uc002tdu.2_Missense_Mutation_p.E443K|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1256					intracellular transport		binding			skin(2)	2						GTGATTTAAGGGAAGATGCTTT	0.45													69	392					0	0	0	0	AA	108488226	AA	AA	108488225	3	1	202	1	0	0	0	0	1	0	0	0	13353	1223	43	4	3843	4	RGPD4	2	108488225	Missense_Mutation	DNP	GG	TCGA-CV-6943-01A-11D-1912-08	69237953	108488225	134711148	8	37050											
NCKAP5	344148	broad.mit.edu	37	chr2	133541833	133541833	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagaggggccctgagctctCagtcttcatgaatcgtgaga	11	9	12	9	1	3	4	2	3	2	2	5	5	3	4	1	2	1	1	1	2	2	1			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr2:133541833C>T	uc002ttp.2	-	14	2925	c.2551G>A	c.(2551-2553)GAG>AAG	p.E851K	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	851							protein binding				0						CCTGAGCTCTCAGTCTTCATG	0.537													8	142					0	0	0	0	T	133541833	T	T	133541833	3	4	202	1	0	0	0	0	1	0	0	0	10277	835	29	2	3206	2	NCKAP5	2	133541833	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	25053608	133541833	109657540	9	37051											
CASP8	841	broad.mit.edu	37	chr2	202137479	202137481	+	In_Frame_Del	DEL	ACT	-	-																															cctgctgaagataatcaacgActatgaagaattcagcaaag																										TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr2:202137479_202137481delACT	uc002uxr.1	+	5	739_741	c.530_532delACT	c.(529-534)GACTAT>GAT	p.Y178del	CASP8_uc010ftc.1_In_Frame_Del_p.Y178del|CASP8_uc002uxo.1_In_Frame_Del_p.Y178del|CASP8_uc002uxp.1_In_Frame_Del_p.Y210del|CASP8_uc002uxq.1_In_Frame_Del_p.Y178del|CASP8_uc002uxs.1_In_Frame_Del_p.Y178del|CASP8_uc002uxt.1_In_Frame_Del_p.Y237del|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_In_Frame_Del_p.Y75del|CASP8_uc002uxv.1_In_Frame_Del_p.Y178del|CASP8_uc002uxw.1_In_Frame_Del_p.Y178del|CASP8_uc002uxy.1_In_Frame_Del_p.Y178del|CASP8_uc002uxx.1_In_Frame_Del_p.Y178del|CASP8_uc010ftf.2_In_Frame_Del_p.Y178del|CASP8_uc010fte.1_In_Frame_Del_p.Y75del	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	178					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						ATAATCAACGACTATGAAGAATT	0.429										HNSCC(4;0.00038)			---	---	---								-	202137481	-	-	202137479	7	5	202	1	0	1	0	1	0	0	0	0	2689	275	10	0	821	0	CASP8	2	202137479	In_Frame_Del	DEL	ACT	TCGA-CV-6943-01A-11D-1912-08	68595646	202137479	41061894	10	37052											
TGFBR2	7048	broad.mit.edu	37	chr3	30691947	30691947	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caatgacaacatcatcttctCagaaggtgagttttcttctc	11	14	6	10	0	5	3	2	2	4	1	7	3	5	3	0	1	1	1	0	1	3	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr3:30691947C>G	uc003ceo.2	+	3	831	c.449C>G	c.(448-450)TCA>TGA	p.S150*	TGFBR2_uc003cen.2_Nonsense_Mutation_p.S175*	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	150	Extracellular (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						ATCATCTTCTCAGAAGGTGAG	0.433													4	62					0	0	0	0	G	30691947	G	G	30691947	4	3	202	1	0	0	0	0	0	1	0	0	15888	838	29	2	538	2	TGFBR2	3	30691947	Nonsense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08		30691947	167330483	11	37053											
RBM15B	29890	broad.mit.edu	37	chr3	51430468	51430468	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaccgagaccggacttttttGgaaggggactggaccagccc	9	7	14	11	2	0	1	0	0	0	1	0	7	0	5	4	5	1	0	4	5	1	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr3:51430468G>A	uc003dbd.2	+	1	1738	c.1638G>A	c.(1636-1638)TTG>TTA	p.L546L		NM_013286	NP_037418	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	546					interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GGACTTTTTTGGAAGGGGACT	0.627													6	55					0	0	0	0	A	51430468	A	A	51430468	2	1	202	1	0	0	0	0	0	0	0	1	13182	1339	47	4		4	RBM15B	3	51430468	Silent	SNP	G	TCGA-CV-6943-01A-11D-1912-08	20738521	51430468	146591962	12	37054											
KNG1	3827	broad.mit.edu	37	chr3	186435424	186435424	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaattgactgcaatgacaaGgatttatttaaagctgtgga	15	12	10	4	0	0	2	0	2	0	0	0	5	0	4	0	2	2	2	0	2	6	5			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr3:186435424G>T	uc011bsa.1	+	1	305	c.93G>T	c.(91-93)AAG>AAT	p.K31N	KNG1_uc003fqr.2_Missense_Mutation_p.K31N	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	31	Cystatin 1.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GCAATGACAAGGATTTATTTA	0.393													6	70					3.59834e-05	0.000179917	1	0	T	186435424	T	T	186435424	3	4	202	1	0	0	0	0	1	0	0	0	8466	991	35	4	95	4	KNG1	3	186435424	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	135004956	186435424	11587006	13	37055											
FAT4	79633	broad.mit.edu	37	chr4	126241929	126241929	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgcagacattaatggtcaaCtatcctacacaatcattcaa	16	11	4	10	0	3	1	3	0	0	1	4	1	4	1	1	1	3	1	1	1	6	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr4:126241929C>G	uc003ifj.3	+	1	4363	c.4363C>G	c.(4363-4365)CTA>GTA	p.L1455V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1455	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TAATGGTCAACTATCCTACAC	0.393													5	104					0	0	0	0	G	126241929	G	G	126241929	3	3	202	1	0	0	0	0	1	0	0	0	5724	564	20	4	4365	4	FAT4	4	126241929	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08		126241929	64912347	14	37056											
FAT1	2195	broad.mit.edu	37	chr4	187539417	187539417	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctggccagtatggaaaactGataccacttagttgtctcat	11	12	8	10	0	1	1	1	1	1	0	2	2	1	2	3	2	2	2	3	2	5	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr4:187539417G>A	uc003izf.2	-	10	8511	c.8323C>T	c.(8323-8325)CAG>TAG	p.Q2775*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2775	Extracellular (Potential).|Cadherin 25.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATGGAAAACTGATACCACTTA	0.453										HNSCC(5;0.00058)			21	237					0	0	0	0	A	187539417	A	A	187539417	4	1	202	1	0	0	0	0	0	1	0	0	5721	1299	45	2	5515	2	FAT1	4	187539417	Nonsense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	61297488	187539417	3614859	15	37057											
PGBD1	84547	broad.mit.edu	37	chr6	28269233	28269233	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaatgaataaaaatttcctCttgtatgctcccctggaaga	14	12	6	9	0	1	2	0	1	1	1	3	3	3	3	3	1	1	2	3	1	7	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr6:28269233C>G	uc003nky.2	+	7	1972	c.1602C>G	c.(1600-1602)CTC>CTG	p.L534L	PGBD1_uc003nkz.2_Silent_p.L534L	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	534					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						AAAATTTCCTCTTGTATGCTC	0.353													3	85					0	0	0	0	G	28269233	G	G	28269233	2	3	202	1	0	0	0	0	0	0	0	1	11835	900	32	2		2	PGBD1	6	28269233	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08		28269233	142845834	16	37058											
HLA-A	3105	broad.mit.edu	37	chr6	29912175	29912175	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcccctcaccctgagatgggGtaaggagggagatgggggtg	8	6	19	8	0	1	2	1	1	0	2	1	5	1	3	3	6	0	1	3	6	1	1	rs41547331		TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr6:29912175G>T	uc003nol.2	+	4	895	c.895_splice	c.e4+1	p.E299_splice	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc010jrq.2_Splice_Site_p.E178_splice|HLA-A_uc003nok.2_Splice_Site_p.E178_splice|HLA-A_uc003non.2_Splice_Site_p.E299_splice|HLA-A_uc003noo.2_Splice_Site_p.E299_splice|HLA-A_uc010jrr.2_Splice_Site_p.V299_splice|HLA-A_uc003nom.2_Splice_Site_p.E178_splice|HLA-A_uc010klp.2_Splice_Site_p.D271_splice|HLA-A_uc011dmc.1_Splice_Site_p.E178_splice|HLA-A_uc011dmd.1_Splice_Site_p.E178_splice	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A						antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTGAGATGGGGTAAGGAGGGA	0.597									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			7	37					8.12818e-05	0.000396958	1	0	T	29912175	T	T	29912175	5	4	202	1	0	0	0	0	0	0	1	0	7234	1275	44	4	910	4	HLA-A	6	29912175	Splice_Site	SNP	G	TCGA-CV-6943-01A-11D-1912-08	1642942	29912175	141202892	17	37059											
USP49	25862	broad.mit.edu	37	chr6	41773790	41773790	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaaggacagctccgtggccGagctgttggttggcttgcca	6	10	14	11	2	1	0	1	0	0	0	2	2	2	1	3	4	3	5	3	4	1	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr6:41773790G>A	uc003ori.2	-	4	1154	c.932C>T	c.(931-933)TCG>TTG	p.S311L		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	311					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTCCGTGGCCGAGCTGTTGGT	0.572													7	72					0	0	0	0	A	41773790	A	A	41773790	3	1	202	1	0	0	0	0	1	0	0	0	17148	1059	37	1	1006	1	USP49	6	41773790	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	11861615	41773790	129341277	18	37060											
KIAA1009	22832	broad.mit.edu	37	chr6	84872909	84872909	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttggtccctctctttcttCattttttcgaagtctacttc	4	20	5	12	1	4	0	1	0	3	0	8	1	5	0	1	1	1	1	1	1	2	8			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr6:84872909C>T	uc010kbp.2	-	19	2563	c.2466G>A	c.(2464-2466)ATG>ATA	p.M822I	KIAA1009_uc003pkj.3_Missense_Mutation_p.M746I|KIAA1009_uc003pki.3_Missense_Mutation_p.M208I	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	822	Potential.				cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		TCTCTTTCTTCATTTTTTCGA	0.333													13	119					0	0	0	0	T	84872909	T	T	84872909	3	4	202	1	0	0	0	0	1	0	0	0	8242	826	29	2	1781	2	KIAA1009	6	84872909	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	43099119	84872909	86242158	19	37061											
ARID1B	57492	broad.mit.edu	37	chr6	157528758	157528758	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcattggaaacttgataagCttcctagaggatggggtcac	12	10	12	7	0	1	2	1	1	0	1	2	4	2	4	1	4	3	2	1	4	3	5			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr6:157528758C>T	uc003qqn.2	+	20	6581	c.6429C>T	c.(6427-6429)AGC>AGT	p.S2143S	ARID1B_uc003qqo.2_Silent_p.S2103S|ARID1B_uc003qqp.2_Silent_p.S2090S	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2148					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		ACTTGATAAGCTTCCTAGAGG	0.552													7	139					0	0	0	0	T	157528758	T	T	157528758	2	4	202	1	0	0	0	0	0	0	0	1	914	796	28	4		4	ARID1B	6	157528758	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08	72655849	157528758	13586309	20	37062											
TAGAP	117289	broad.mit.edu	37	chr6	159463226	159463226	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatctgatgcaggggagaGccttctcatgagaaagggcc	13	7	13	8	0	2	3	1	2	2	2	3	5	2	3	2	3	2	1	2	3	3	1			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr6:159463226G>T	uc003qrz.2	-	5	531	c.199C>A	c.(199-201)CTC>ATC	p.L67I	TAGAP_uc011eft.1_Missense_Mutation_p.L4I|TAGAP_uc003qsa.2_Intron|TAGAP_uc003qsb.2_Missense_Mutation_p.L67I|uc003qsc.2_5'Flank	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	67					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		GCAGGGGAGAGCCTTCTCATG	0.448													9	217					0.000274275	0.00130904	1	0	T	159463226	T	T	159463226	3	4	202	1	0	0	0	0	1	0	0	0	15603	971	34	4	2038	4	TAGAP	6	159463226	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	1934468	159463226	11651841	21	37063											
TARP	445347	broad.mit.edu	37	chr7	38305122	38305122	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccctcctgggatcccagaatCgtgttgctcttcttttcttg	4	16	8	13	1	3	1	0	0	3	1	6	2	5	2	3	1	1	2	3	1	1	5			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr7:38305122C>G	uc003tge.1	-	5	962	c.585G>C	c.(583-585)ACG>ACC	p.T195T	uc003tfz.1_Intron|TARP_uc003tgb.2_5'UTR|TARP_uc003tgc.1_5'UTR|TARP_uc003tgd.1_5'UTR|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						ATCCCAGAATCGTGTTGCTCT	0.418													6	175					0	0	0	0	G	38305122	G	G	38305122	2	3	202	1	0	0	0	0	0	0	0	1	15624	884	31	3		3	TARP	7	38305122	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08		38305122	120833541	22	37064											
MYOM2	9172	broad.mit.edu	37	chr8	2020522	2020522	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaggcgagacggtcactctCaagtgcaccatgctggtgac	10	7	13	11	2	2	2	2	1	1	1	3	4	2	2	1	3	2	2	1	3	2	0			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr8:2020522C>G	uc003wpx.3	+	9	1029	c.891C>G	c.(889-891)CTC>CTG	p.L297L	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	297	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CGGTCACTCTCAAGTGCACCA	0.617													3	31					0	0	0	0	G	2020522	G	G	2020522	2	3	202	1	0	0	0	0	0	0	0	1	10145	813	29	2		2	MYOM2	8	2020522	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08		2020522	144343500	23	37065											
UBR5	51366	broad.mit.edu	37	chr8	103358503	103358503	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctggctgtatcatccccatCatctccatcttcatcatccc	7	13	4	17	0	6	0	4	0	2	0	9	0	8	0	4	1	0	3	4	1	1	2			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr8:103358503C>T	uc003ykr.1	-	7	730	c.697G>A	c.(697-699)GAT>AAT	p.D233N	UBR5_uc003yks.1_Missense_Mutation_p.D233N	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	233					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TCATCCCCATCATCTCCATCT	0.433													7	99					0	0	0	0	T	103358503	T	T	103358503	3	4	202	1	0	0	0	0	1	0	0	0	16973	826	29	2	7914	2	UBR5	8	103358503	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	101337981	103358503	43005519	24	37066											
RIMS2	9699	broad.mit.edu	37	chr8	104709390	104709390	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatcacagcaacagcaagaaCagaagggtgatgcgccaacc	17	3	10	11	1	1	3	1	1	0	2	1	3	1	3	2	1	6	2	2	1	6	0			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr8:104709390C>T	uc003ylp.2	+	2	392	c.253C>T	c.(253-255)CAG>TAG	p.Q85*		NM_001100117	NP_001093587	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	116	RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACAGCAAGAACAGAAGGGTGA	0.413										HNSCC(12;0.0054)			11	78					0	0	0	0	T	104709390	T	T	104709390	4	4	202	1	0	0	0	0	0	1	0	0	13433	479	17	4	259	4	RIMS2	8	104709390	Nonsense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	1350887	104709390	41654632	25	37067											
ANGPT1	284	broad.mit.edu	37	chr8	108509701	108509701	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggttatatcttctcccaCtgttttctggacttcggcgc	4	16	8	13	3	3	0	0	0	3	0	6	1	4	1	2	3	0	2	2	3	2	6			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr8:108509701C>G	uc003ymn.2	-	1	554	c.86G>C	c.(85-87)AGT>ACT	p.S29T	ANGPT1_uc003ymo.2_Missense_Mutation_p.S29T	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	29					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TCTTCTCCCACTGTTTTCTGG	0.483													5	65					0	0	0	0	G	108509701	G	G	108509701	3	3	202	1	0	0	0	0	1	0	0	0	610	565	20	4	1446	4	ANGPT1	8	108509701	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	3800311	108509701	37854321	26	37068											
ATAD2	29028	broad.mit.edu	37	chr8	124359425	124359425	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aacagtgttttgcaggagtgGtttcacaacggtggacagtg	10	11	14	6	1	1	0	1	0	0	0	1	2	1	2	0	4	3	3	0	4	2	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	8cf9a8ac-789d-4269-9bb5-0a85488cdf63	g.chr8:124359425G>T	uc003yqh.3	-	16	2227	c.2119C>A	c.(2119-2121)CCA>ACA	p.P707T	ATAD2_uc011lii.1_Missense_Mutation_p.P498T|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.P707T	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	707					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TGCAGGAGTGGTTTCACAACG	0.433													4	116					0.000602214	0.00213753	1	0	T	124359425	T	T	124359425	3	4	202	1	0	0	0	0	1	0	0	0	1073	1261	44	4	2105	4	ATAD2	8	124359425	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	15849724	124359425	22004597	27	37069											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			5	20					0	0	0	0	A	21971120	A	A	21971120	4	1	202	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08		21971120	119242311	28	37070											
AQP7	364	broad.mit.edu	37	chr9	33385823	33385823	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggttgttctcctggtccgtGatggcgaagagacacagctg	7	10	15	9	2	1	2	0	1	1	1	3	4	2	2	2	3	1	3	2	3	1	2			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr9:33385823G>A	uc003zst.2	-	7	739	c.567C>T	c.(565-567)ATC>ATT	p.I189I	SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_Silent_p.I132I|AQP7_uc010mjs.2_Silent_p.I97I|AQP7_uc010mjt.2_Silent_p.I97I|AQP7_uc011lnx.1_Silent_p.I189I|AQP7_uc011lny.1_Silent_p.I188I|AQP7_uc003zss.3_Silent_p.I97I|AQP7_uc011lnz.1_Silent_p.I97I|AQP7_uc011loa.1_Missense_Mutation_p.H58Y	NM_001170	NP_001161	O14520	AQP7_HUMAN	aquaporin 7	189	Helical; (Potential).				excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCTGGTCCGTGATGGCGAAGA	0.622													5	74					0	0	0	0	A	33385823	A	A	33385823	2	1	202	1	0	0	0	0	0	0	0	1	831	1280	45	2		2	AQP7	9	33385823	Silent	SNP	G	TCGA-CV-6943-01A-11D-1912-08	11414703	33385823	107827608	29	37071											
COBRA1	25920	broad.mit.edu	37	chr9	140150358	140150358	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtttctcttggcttcctcaGacagagaatggtgtgctgct	6	14	12	9	0	2	2	1	0	1	2	4	3	3	2	1	3	2	4	1	3	1	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr9:140150358G>C	uc004cmm.3	+	2	306	c.103_splice	c.e2-1	p.T35_splice		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1						negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		GGCTTCCTCAGACAGAGAATG	0.632													11	113					0	0	0	0	C	140150358	C	C	140150358	5	2	202	1	0	0	0	0	0	0	1	0	3670	956	33	2	108	2	COBRA1	9	140150358	Splice_Site	SNP	G	TCGA-CV-6943-01A-11D-1912-08	106764535	140150358	1063073	30	37072											
APBB1IP	54518	broad.mit.edu	37	chr10	26789871	26789871	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccttgcagaatcaacatcAttcagcatctctacaagcat	13	11	5	12	0	4	1	3	0	1	1	6	1	5	1	1	0	5	3	1	0	4	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr10:26789871A>T	uc001iss.2	+	5	605	c.284A>T	c.(283-285)CAT>CTT	p.H95L	APBB1IP_uc001isr.2_Missense_Mutation_p.H95L|APBB1IP_uc009xks.1_Missense_Mutation_p.H95L	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	95					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						AATCAACATCATTCAGCATCT	0.448													9	109					0	0	0	0	T	26789871	T	T	26789871	3	4	202	1	0	0	0	0	1	0	0	0	760	217	8	5	294	5	APBB1IP	10	26789871	Missense_Mutation	SNP	A	TCGA-CV-6943-01A-11D-1912-08		26789871	108744876	31	37073											
FAM13C	220965	broad.mit.edu	37	chr10	61014170	61014170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattctgtatcggtcataaaGcggctttatgaggttcttgt	9	16	10	6	2	3	1	1	1	2	0	4	1	3	1	0	3	1	3	0	3	5	7			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr10:61014170G>A	uc001jkn.2	-	12	1404	c.1270C>T	c.(1270-1272)CTT>TTT	p.L424F	FAM13C_uc001jko.2_Missense_Mutation_p.L326F|FAM13C_uc010qid.1_Missense_Mutation_p.L341F|FAM13C_uc010qie.1_Missense_Mutation_p.L341F|FAM13C_uc010qif.1_Missense_Mutation_p.L446F|FAM13C_uc001jkp.2_Missense_Mutation_p.L341F	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	424										ovary(2)	2						CGGTCATAAAGCGGCTTTATG	0.348													7	115					0	0	0	0	A	61014170	A	A	61014170	3	1	202	1	0	0	0	0	1	0	0	0	5482	971	34	4	503	4	FAM13C	10	61014170	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	34224299	61014170	74520577	32	37074											
RNLS	55328	broad.mit.edu	37	chr10	90034742	90034742	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgggaaatccaatcgccatCatccaggggctcttcgcaca	11	8	9	13	2	2	0	1	0	1	0	6	1	4	1	3	3	0	2	3	3	2	1			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr10:90034742C>T	uc001kfd.2	-	7	1059	c.924G>A	c.(922-924)ATG>ATA	p.M308I	RNLS_uc010qms.1_Missense_Mutation_p.M225I	NM_018363	NP_060833	Q5VYX0	RNLS_HUMAN	renalase isoform 2	Error:Variant_position_missing_in_Q5VYX0_after_alignment						extracellular region	oxidoreductase activity			ovary(1)	1						CAATCGCCATCATCCAGGGGC	0.393													6	54					0	0	0	0	T	90034742	T	T	90034742	3	4	202	1	0	0	0	0	1	0	0	0	13570	826	29	2	27	2	RNLS	10	90034742	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	29020572	90034742	45500005	33	37075											
PLCE1	51196	broad.mit.edu	37	chr10	96028705	96028705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtccttttgcaaggctgtcGaagtgtagaattggactgct	8	13	13	7	1	0	1	0	0	0	1	2	3	1	2	1	3	2	4	1	3	4	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr10:96028705G>A	uc001kjk.2	+	17	4935	c.4301G>A	c.(4300-4302)CGA>CAA	p.R1434Q	PLCE1_uc010qnx.1_Missense_Mutation_p.R1418Q|PLCE1_uc001kjm.2_Missense_Mutation_p.R1126Q	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1434	PI-PLC X-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				CAAGGCTGTCGAAGTGTAGAA	0.488													10	69					0	0	0	0	A	96028705	A	A	96028705	3	1	202	1	0	0	0	0	1	0	0	0	12089	1058	37	1	4649	1	PLCE1	10	96028705	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	5993963	96028705	39506042	34	37076											
NUP98	4928	broad.mit.edu	37	chr11	3697545	3697545	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtgttgagtcggaggttctAtcaggaggatgatgcagact	9	11	16	5	1	2	3	1	2	1	1	3	6	2	6	0	5	1	3	0	5	1	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr11:3697545A>G	uc001lyh.2	-	33	5538	c.5247T>C	c.(5245-5247)GAT>GAC	p.D1749D	NUP98_uc001lyi.2_Silent_p.D1675D|NUP98_uc001lyg.2_Silent_p.D714D	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1766					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CGGAGGTTCTATCAGGAGGAT	0.567			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								12	89					0	0	0	0	G	3697545	G	G	3697545	2	3	202	1	0	0	0	0	0	0	0	1	10827	446	16	5		5	NUP98	11	3697545	Silent	SNP	A	TCGA-CV-6943-01A-11D-1912-08		3697545	131308971	35	37077											
KAT5	10524	broad.mit.edu	37	chr11	65482118	65482118	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcaagccgtggtacttctcCccgtacccacaggaactcac	9	8	7	17	2	3	0	2	0	1	0	4	1	3	1	4	2	4	2	4	2	4	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr11:65482118C>T	uc001ofi.2	+	8	994	c.744C>T	c.(742-744)TCC>TCT	p.S248S	KAT5_uc001ofj.2_Silent_p.S196S|KAT5_uc001ofk.2_Silent_p.S281S|KAT5_uc010roo.1_Silent_p.S229S|KAT5_uc001ofl.2_Silent_p.S37S	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	248					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						GGTACTTCTCCCCGTACCCAC	0.562													25	136					0	0	0	0	T	65482118	T	T	65482118	2	4	202	1	0	0	0	0	0	0	0	1	8022	610	22	4		4	KAT5	11	65482118	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08	61784573	65482118	69524398	36	37078											
MED17	9440	broad.mit.edu	37	chr11	93528169	93528169	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcgggaagctgttcaaattAaatcacaagtccctcacatt	13	11	6	11	1	3	0	3	0	0	0	5	1	4	1	1	1	1	2	1	1	5	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr11:93528169A>G	uc001pem.3	+	6	1230	c.955A>G	c.(955-957)AAA>GAA	p.K319E		NM_004268	NP_004259	Q9NVC6	MED17_HUMAN	mediator complex subunit 17	319					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TGTTCAAATTAAATCACAAGT	0.418													4	114					0	0	0	0	G	93528169	G	G	93528169	3	3	202	1	0	0	0	0	1	0	0	0	9488	363	13	5	977	5	MED17	11	93528169	Missense_Mutation	SNP	A	TCGA-CV-6943-01A-11D-1912-08	28046051	93528169	41478347	37	37079											
DYNC2H1	79659	broad.mit.edu	37	chr11	103062954	103062954	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcattttaacatcagtgtttCaaggagattggggctcagac	11	13	10	7	0	4	2	4	0	0	2	4	3	4	2	0	3	1	2	0	3	2	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr11:103062954C>G	uc001pho.2	+	47	7813	c.7669C>G	c.(7669-7671)CAA>GAA	p.Q2557E	DYNC2H1_uc001phn.1_Missense_Mutation_p.Q2557E|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2557					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		ATCAGTGTTTCAAGGAGATTG	0.338													4	24					0	0	0	0	G	103062954	G	G	103062954	3	3	202	1	0	0	0	0	1	0	0	0	4868	827	29	2	7855	2	DYNC2H1	11	103062954	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	9534785	103062954	31943562	38	37080											
PLEKHA5	54477	broad.mit.edu	37	chr12	19282753	19282753	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggcggcggatctgaaccTggagtggatctccctgcccc	6	8	13	14	2	2	1	0	1	2	0	3	4	2	4	4	5	2	0	4	5	1	0			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr12:19282753T>G	uc001reb.2	+	1	106	c.20T>G	c.(19-21)CTG>CGG	p.L7R	PLEKHA5_uc010sie.1_Missense_Mutation_p.L7R|PLEKHA5_uc001rea.2_Missense_Mutation_p.L7R|PLEKHA5_uc009zin.2_5'UTR|PLEKHA5_uc001rdz.3_Missense_Mutation_p.L7R	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	7							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GATCTGAACCTGGAGTGGATC	0.517													3	21					0	0	0	0	G	19282753	G	G	19282753	3	3	202	1	0	0	0	0	1	0	0	0	12114	1580	55	5	22	5	PLEKHA5	12	19282753	Missense_Mutation	SNP	T	TCGA-CV-6943-01A-11D-1912-08		19282753	114569142	39	37081											
RAPGEF3	10411	broad.mit.edu	37	chr12	48143717	48143717	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccctgctggacttacacacGgtccctgccttgctgtgtgg	4	11	12	14	1	0	0	0	0	0	0	1	1	1	1	3	3	4	2	3	3	1	2			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr12:48143717G>A	uc009zkp.2	-	7	1127	c.687C>T	c.(685-687)ACC>ACT	p.T229T	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Silent_p.T229T|RAPGEF3_uc001rpz.3_Silent_p.T271T|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Silent_p.T283T|RAPGEF3_uc001rqb.3_Silent_p.T271T	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	229					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		ACTTACACACGGTCCCTGCCT	0.567													23	301					0	0	0	0	A	48143717	A	A	48143717	2	1	202	1	0	0	0	0	0	0	0	1	13110	1103	39	1		1	RAPGEF3	12	48143717	Silent	SNP	G	TCGA-CV-6943-01A-11D-1912-08	28860964	48143717	85708178	40	37082											
SRGAP1	57522	broad.mit.edu	37	chr12	64502717	64502717	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcttctgtctgtaggaataGataatctctatgagagggcg	11	13	11	6	1	4	2	0	1	4	2	5	4	4	3	0	2	0	1	0	2	5	5			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr12:64502717G>C	uc010ssp.1	+	16	1875	c.1819G>C	c.(1819-1821)GAT>CAT	p.D607H	SRGAP1_uc001srv.2_Missense_Mutation_p.D544H	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	607	Rho-GAP.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		TGTAGGAATAGATAATCTCTA	0.443													12	89					0	0	0	0	C	64502717	C	C	64502717	3	2	202	1	0	0	0	0	1	0	0	0	15211	942	33	2	1881	2	SRGAP1	12	64502717	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	16359000	64502717	69349178	41	37083											
MYBPC1	4604	broad.mit.edu	37	chr12	102067320	102067320	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttattagaaaagcagagaGgagccactctgggaaatatg	16	9	11	5	0	1	2	0	0	1	2	1	5	1	4	1	2	2	1	1	2	6	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr12:102067320G>A	uc001tii.2	+	24	2810	c.2708G>A	c.(2707-2709)AGG>AAG	p.R903K	MYBPC1_uc001tig.2_Missense_Mutation_p.R910K|MYBPC1_uc010svq.1_Missense_Mutation_p.R872K|MYBPC1_uc001tih.2_Missense_Mutation_p.R910K|MYBPC1_uc001tij.2_Missense_Mutation_p.R885K|MYBPC1_uc010svr.1_Missense_Mutation_p.R885K|MYBPC1_uc010svs.1_Missense_Mutation_p.R903K|MYBPC1_uc010svt.1_Missense_Mutation_p.R873K|MYBPC1_uc010svu.1_Missense_Mutation_p.R866K|MYBPC1_uc001tik.2_Missense_Mutation_p.R859K|MYBPC1_uc001til.2_5'UTR|MYBPC1_uc001tim.2_5'UTR	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	903	Ig-like C2-type 6.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						AAAGCAGAGAGGAGCCACTCT	0.388													44	187					0	0	0	0	A	102067320	A	A	102067320	3	1	202	1	0	0	0	0	1	0	0	0	10064	1000	35	4	2885	4	MYBPC1	12	102067320	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	37564603	102067320	31784575	42	37084											
TCHP	84260	broad.mit.edu	37	chr12	110345367	110345367	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaagagaacaaacggtatGaaaatgaatatgaaagggcc	20	5	11	5	1	0	4	0	3	0	1	0	5	0	4	1	2	3	2	1	2	9	2			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr12:110345367G>A	uc001tpn.2	+	6	715	c.562G>A	c.(562-564)GAA>AAA	p.E188K	TCHP_uc001tpo.1_RNA|TCHP_uc001tpp.2_Missense_Mutation_p.E188K	NM_001143852	NP_001137324	Q9BT92	TCHP_HUMAN	trichoplein	188	Glu-rich.|Interaction with keratin proteins.|Potential.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			skin(1)	1						CAAACGGTATGAAAATGAATA	0.507													8	104					0	0	0	0	A	110345367	A	A	110345367	3	1	202	1	0	0	0	0	1	0	0	0	15768	1291	45	2	580	2	TCHP	12	110345367	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	8278047	110345367	23506528	43	37085			1	54		2	2	13	N	G_-	2.868478e-05
TCHP	84260	broad.mit.edu	37	chr12	110345379	110345380	+	Frame_Shift_Ins	INS	-	A	A																															acggtatgaaaatgaatatgINSaaagggcccgaagggaggcg																										TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr12:110345379_110345380insA	uc001tpn.2	+	6	727_728	c.574_575insA	c.(574-576)GAAfs	p.E192fs	TCHP_uc001tpo.1_RNA|TCHP_uc001tpp.2_Frame_Shift_Ins_p.E192fs	NM_001143852	NP_001137324	Q9BT92	TCHP_HUMAN	trichoplein	192	Glu-rich.|Interaction with keratin proteins.|Potential.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			skin(1)	1						AAATGAATATGAAAGGGCCCGA	0.51													---	---	---								A	110345380	A	A	110345379	7	5	202	1	0	1	1	0	0	0	0	0	15768	1291	45	0	592	0	TCHP	12	110345379	Frame_Shift_Ins	INS	-	TCGA-CV-6943-01A-11D-1912-08	12	110345379	23506516	44	37086			1	54		2	2	13	N	G_-	2.868478e-05
TCTN2	79867	broad.mit.edu	37	chr12	124172678	124172678	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agactttggttacaaacaagGagatcccattatgactgtaa	15	11	8	7	0	0	3	0	1	0	2	1	4	1	3	1	2	2	2	1	2	5	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr12:124172678G>C	uc001ufp.2	+	7	973	c.845G>C	c.(844-846)GGA>GCA	p.G282A	TCTN2_uc009zya.2_Missense_Mutation_p.G281A	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	282	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TACAAACAAGGAGATCCCATT	0.343													14	102					0	0	0	0	C	124172678	C	C	124172678	3	2	202	1	0	0	0	0	1	0	0	0	15789	1174	41	2	871	2	TCTN2	12	124172678	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	13827299	124172678	9679217	45	37087											
TRIM13	10206	broad.mit.edu	37	chr13	50586806	50586806	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggctttcaaagatgtgtcaGaacccattgtatttctgcaa	12	13	8	8	0	3	2	2	0	1	2	3	2	3	2	1	1	2	3	1	1	4	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr13:50586806G>C	uc001vdq.1	+	3	1043	c.730G>C	c.(730-732)GAA>CAA	p.E244Q	DLEU2_uc001vdn.1_Intron|DLEU2_uc001vdo.1_Intron|KCNRG_uc001vdt.2_5'Flank|KCNRG_uc001vdu.2_5'Flank|TRIM13_uc001vdp.1_Missense_Mutation_p.E247Q|TRIM13_uc001vdr.1_Missense_Mutation_p.E244Q|TRIM13_uc001vds.1_Missense_Mutation_p.E244Q	NM_052811	NP_434698	O60858	TRI13_HUMAN	ret finger protein 2 isoform 1	244					anatomical structure morphogenesis|ER-associated protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination	cytoplasm|endoplasmic reticulum membrane|integral to membrane	protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.53e-10)|COAD - Colon adenocarcinoma(199;0.205)		AGATGTGTCAGAACCCATTGT	0.423													4	53					0	0	0	0	C	50586806	C	C	50586806	3	2	202	1	0	0	0	0	1	0	0	0	16555	943	33	2	745	2	TRIM13	13	50586806	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08		50586806	64583072	46	37088											
OR4N2	390429	broad.mit.edu	37	chr14	20296393	20296393	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatctacacgcgccccttCagggctttcccagctgacaa	8	10	7	16	2	3	1	2	1	1	0	4	1	4	1	3	1	2	2	3	1	2	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr14:20296393C>T	uc010tkv.1	+	1	786	c.786C>T	c.(784-786)TTC>TTT	p.F262F		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CGCGCCCCTTCAGGGCTTTCC	0.458													15	93					0	0	0	0	T	20296393	T	T	20296393	2	4	202	1	0	0	0	0	0	0	0	1	11131	825	29	2		2	OR4N2	14	20296393	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08		20296393	87053147	47	37089											
PRKD1	5587	broad.mit.edu	37	chr14	30107997	30107997	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagtggatgacaaatgtgtgCggcactttaactttagacat	12	12	11	6	1	0	2	0	1	0	1	0	4	0	3	0	2	2	1	0	2	3	4	rs144272752	byFrequency	TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr14:30107997C>T	uc001wqh.2	-	5	991	c.810G>A	c.(808-810)CCG>CCA	p.P270P		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	270	Phorbol-ester/DAG-type 2.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity	p.P270L(1)		lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CAAATGTGTGCGGCACTTTAA	0.468													8	44					0	0	0	0	T	30107997	T	T	30107997	2	4	202	1	0	0	0	0	0	0	0	1	12580	755	27	1		1	PRKD1	14	30107997	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08	9811604	30107997	77241543	48	37090											
VIPAR	63894	broad.mit.edu	37	chr14	77901690	77901690	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctttgcgggggtgctttCggaagatctcagtctgtcct	5	13	14	9	2	2	1	1	0	2	1	5	2	3	2	1	4	2	2	1	4	1	2			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr14:77901690C>A	uc001xtt.1	-	15	1297	c.959G>T	c.(958-960)CGA>CTA	p.R320L	VIPAR_uc001xtu.1_Missense_Mutation_p.R320L|VIPAR_uc010tvj.1_Missense_Mutation_p.R271L|VIPAR_uc001xtv.1_Missense_Mutation_p.R320L	NM_022067	NP_071350	Q9H9C1	VIPAR_HUMAN	hypothetical protein LOC63894	320					endosome to lysosome transport|intracellular protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	early endosome|late endosome|recycling endosome	protein binding			central_nervous_system(1)	1						GGGGTGCTTTCGGAAGATCTC	0.463													9	106					3.07112e-06	1.55406e-05	1	0	A	77901690	A	A	77901690	3	1	202	1	0	0	0	0	1	0	0	0	17236	884	31	3	550	3	VIPAR	14	77901690	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	47793693	77901690	29447850	49	37091											
MKRN3	7681	broad.mit.edu	37	chr15	23811808	23811808	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcctgcattgaagcacaCgagaaagatatggaactctc	14	7	11	9	1	1	3	0	1	1	2	2	5	1	4	1	2	3	2	1	2	4	2			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr15:23811808C>G	uc001ywh.3	+	1	1355	c.879C>G	c.(877-879)CAC>CAG	p.H293Q	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.H293Q	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	293	Makorin-type Cys-His.					ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TTGAAGCACACGAGAAAGATA	0.532													3	38					0	0	0	0	G	23811808	G	G	23811808	3	3	202	1	0	0	0	0	1	0	0	0	9661	535	19	3	881	3	MKRN3	15	23811808	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08		23811808	78719584	50	37092											
GLYR1	84656	broad.mit.edu	37	chr16	4861236	4861236	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acccagcgcaatggctaagcGgagatccttctgaatgtatt	11	10	10	10	2	1	2	0	1	1	1	2	3	2	2	2	2	2	3	2	2	4	4			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr16:4861236G>T	uc002cxx.3	-	15	1559	c.1522C>A	c.(1522-1524)CGC>AGC	p.R508S	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Missense_Mutation_p.R422S|GLYR1_uc002cya.2_Missense_Mutation_p.R502S|GLYR1_uc010uxv.1_Missense_Mutation_p.R427S	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	508					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						ATGGCTAAGCGGAGATCCTTC	0.507													14	130					1.99824e-07	1.03612e-06	1	0	T	4861236	T	T	4861236	3	4	202	1	0	0	0	0	1	0	0	0	6520	1116	39	3	147	3	GLYR1	16	4861236	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08		4861236	85493517	51	37093											
MYH11	4629	broad.mit.edu	37	chr16	15826519	15826519	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcatgggaccgcgtctcttCatccagggccttcttcagca	6	11	9	15	2	5	0	3	0	2	0	7	1	6	1	3	2	1	1	3	2	0	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr16:15826519C>T	uc002ddy.2	-	27	3660	c.3553G>A	c.(3553-3555)GAA>AAA	p.E1185K	MYH11_uc002ddv.2_Missense_Mutation_p.E1192K|MYH11_uc002ddw.2_Missense_Mutation_p.E1185K|MYH11_uc002ddx.2_Missense_Mutation_p.E1192K|MYH11_uc010bvg.2_Missense_Mutation_p.E1017K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1185	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CGCGTCTCTTCATCCAGGGCC	0.587			T	CBFB	AML								10	108					0	0	0	0	T	15826519	T	T	15826519	3	4	202	1	0	0	0	0	1	0	0	0	10084	835	29	2	2460	2	MYH11	16	15826519	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	10965283	15826519	74528234	52	37094											
SRCAP	10847	broad.mit.edu	37	chr16	30721369	30721369	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagggccttccagcccctctCaaaccccctcatctcatgat	9	9	5	18	0	3	1	3	1	2	0	6	1	4	1	6	1	2	0	6	1	2	1			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr16:30721369C>G	uc002dze.1	+	8	1439	c.1054C>G	c.(1054-1056)CAA>GAA	p.Q352E	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.Q209E|SRCAP_uc010bzz.1_5'UTR|SNORA30_uc002dzh.1_5'Flank	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	352	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CAGCCCCTCTCAAACCCCCTC	0.577													4	29					0	0	0	0	G	30721369	G	G	30721369	3	3	202	1	0	0	0	0	1	0	0	0	15201	827	29	2	1076	2	SRCAP	16	30721369	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	14894850	30721369	59633384	53	37095											
GAS8	2622	broad.mit.edu	37	chr16	90097737	90097737	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atgtcagccgcatccgggagGagctggaccgcgagcgggag	8	4	18	11	5	1	0	1	0	0	0	2	5	2	4	3	4	3	2	3	4	0	0			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr16:90097737G>C	uc002fqi.1	+	3	243	c.121G>C	c.(121-123)GAG>CAG	p.E41Q	GAS8_uc010vps.1_Missense_Mutation_p.E16Q|GAS8_uc002fqh.2_5'UTR|GAS8_uc010vpt.1_Missense_Mutation_p.E41Q|GAS8_uc010vpu.1_5'UTR|GAS8_uc010vpv.1_Missense_Mutation_p.E12Q|GAS8_uc010cjc.1_5'UTR|GAS8_uc010vpw.1_5'UTR|GAS8_uc002fqj.1_5'UTR|C16orf3_uc002fqk.1_5'Flank	NM_001481	NP_001472	O95995	GAS8_HUMAN	growth arrest-specific 8	41	Regulates microtubule-binding (By similarity).				negative regulation of cell proliferation|sperm motility	cilium|Golgi apparatus|microtubule|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.029)		CATCCGGGAGGAGCTGGACCG	0.647													3	51					0	0	0	0	C	90097737	C	C	90097737	3	2	202	1	0	0	0	0	1	0	0	0	6286	1175	41	2	131	2	GAS8	16	90097737	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	59376368	90097737	257016	54	37096											
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	6	8	16	11	2	1	1	1	1	0	0	2	3	2	2	4	5	2	2	4	5	0	1	rs121912651		TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	60					0	0	0	0	A	7577539	A	A	7577539	3	1	202	1	0	0	0	0	1	0	0	0	16448	1115	39	1	548	1	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08		7577539	73617671	55	37097											
KIAA0100	9703	broad.mit.edu	37	chr17	26962166	26962166	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagaggagccaaacacggttCcggagggtctgcagcgcagg	10	4	17	10	3	1	1	0	0	1	1	2	4	2	3	2	5	4	3	2	5	1	1			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr17:26962166C>A	uc002hbu.2	-	16	2538	c.2439G>T	c.(2437-2439)CGG>CGT	p.R813R		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	813						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AAACACGGTTCCGGAGGGTCT	0.527													15	144					1.52009e-12	7.98048e-12	1	0	A	26962166	A	A	26962166	2	1	202	1	0	0	0	0	0	0	0	1	8193	842	30	2		2	KIAA0100	17	26962166	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08	19384627	26962166	54233044	56	37098											
SLFN11	91607	broad.mit.edu	37	chr17	33680115	33680115	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatgtgttcaaagttttctcTtaggaaagttttccgggtct	9	17	9	6	1	3	0	1	0	2	0	5	1	4	1	1	2	0	3	1	2	4	6			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr17:33680115T>A	uc010ctp.2	-	7	2408	c.1966A>T	c.(1966-1968)AGA>TGA	p.R656*	SLFN11_uc010ctq.2_Nonsense_Mutation_p.R656*|SLFN11_uc002hjh.3_Nonsense_Mutation_p.R656*|SLFN11_uc002hjg.3_Nonsense_Mutation_p.R656*|SLFN11_uc010ctr.2_Nonsense_Mutation_p.R656*	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	656						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AAGTTTTCTCTTAGGAAAGTT	0.398													11	101					0	0	0	0	A	33680115	A	A	33680115	4	1	202	1	0	0	0	0	0	1	0	0	14797	1617	56	5	743	5	SLFN11	17	33680115	Nonsense_Mutation	SNP	T	TCGA-CV-6943-01A-11D-1912-08	6717949	33680115	47515095	57	37099											
DDX52	11056	broad.mit.edu	37	chr17	36002253	36002253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttgtgatgctccacacaCacctgggacagacttcttgt	8	13	9	11	0	1	2	0	1	1	1	2	3	2	3	2	1	1	2	2	1	0	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr17:36002253C>T	uc002hoi.1	-	2	210	c.172G>A	c.(172-174)GTG>ATG	p.V58M	DDX52_uc002hoh.1_Translation_Start_Site|DDX52_uc002hoj.1_Translation_Start_Site	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a	58						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				GCTCCACACACACCTGGGACA	0.413													12	76					0	0	0	0	T	36002253	T	T	36002253	3	4	202	1	0	0	0	0	1	0	0	0	4387	478	17	4	1683	4	DDX52	17	36002253	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	2322138	36002253	45192957	58	37100											
KIF18B	146909	broad.mit.edu	37	chr17	43005428	43005428	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctggtccagcctgctcagctCctggggtattttgtcccagc	4	12	11	14	0	1	0	1	0	0	0	4	0	4	0	4	3	4	3	4	3	1	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr17:43005428C>G	uc010wji.1	-	13	2352	c.2251G>C	c.(2251-2253)GAG>CAG	p.E751Q	KIF18B_uc002iht.2_Missense_Mutation_p.E760Q|KIF18B_uc010wjh.1_Missense_Mutation_p.E748Q	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				CTGCTCAGCTCCTGGGGTATT	0.577													3	32					0	0	0	0	G	43005428	G	G	43005428	3	3	202	1	0	0	0	0	1	0	0	0	8320	864	30	2	331	2	KIF18B	17	43005428	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	7003175	43005428	38189782	59	37101											
TMC8	147138	broad.mit.edu	37	chr17	76128900	76128900	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggtagccgccagtccccGcctggcgttttgaggttcca	4	10	12	15	3	0	1	0	1	0	0	2	1	2	1	7	3	1	3	7	3	1	4	rs150261314		TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr17:76128900G>T	uc002jup.2	+	5	862	c.480G>T	c.(478-480)CCG>CCT	p.P160P	TMC6_uc002jul.1_5'Flank|TMC8_uc002juq.2_5'UTR|TMC8_uc010wtr.1_5'Flank	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	160	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			GCCAGTCCCCGCCTGGCGTTT	0.597									Epidermodysplasia_Verruciformis_Familial_Clustering_of				6	102					0.000157383	0.000759781	1	0	T	76128900	T	T	76128900	2	4	202	1	0	0	0	0	0	0	0	1	16057	1074	38	3		3	TMC8	17	76128900	Silent	SNP	G	TCGA-CV-6943-01A-11D-1912-08	33123472	76128900	5066310	60	37102											
UHRF1	29128	broad.mit.edu	37	chr19	4910937	4910937	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatggacgggaggcagaccCacacggtggactcgctgtcc	8	5	14	14	3	0	1	0	0	0	1	2	4	1	4	3	5	0	2	3	5	0	0			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr19:4910937C>A	uc002mbo.2	+	2	208	c.40C>A	c.(40-42)CAC>AAC	p.H14N	uc002mbn.1_5'Flank|UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.H27N	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	14	Ubiquitin-like.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		GAGGCAGACCCACACGGTGGA	0.612											OREG0025176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	134					0.00198382	0.00936184	1	0	A	4910937	A	A	4910937	3	1	202	1	0	0	0	0	1	0	0	0	17035	594	21	4	81	4	UHRF1	19	4910937	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08		4910937	54218046	61	37103											
KLF1	10661	broad.mit.edu	37	chr19	12997871	12997871	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccttctaggccccaccttGaggaagtcatcctgtgtgtc	7	11	9	14	0	2	1	1	1	1	0	4	2	3	2	5	2	0	0	5	2	2	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr19:12997871G>A	uc002mvo.2	-	1	147	c.84C>T	c.(82-84)CTC>CTT	p.L28L		NM_006563	NP_006554	Q13351	KLF1_HUMAN	erythroid Kruppel-like factor	28	Pro-rich.				erythrocyte differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0		Hepatocellular(1079;0.137)		GBM - Glioblastoma multiforme(1328;0.00016)|Lung(535;0.171)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCCACCTTGAGGAAGTCAT	0.622													7	59					0	0	0	0	A	12997871	A	A	12997871	2	1	202	1	0	0	0	0	0	0	0	1	8376	1277	45	2		2	KLF1	19	12997871	Silent	SNP	G	TCGA-CV-6943-01A-11D-1912-08	8086934	12997871	46131112	62	37104											
UQCRFS1	7386	broad.mit.edu	37	chr19	29698963	29698963	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacctttcctagcctcgctgCtttctcttgaagacttcgta	7	15	6	13	2	1	2	0	1	1	1	5	2	2	2	3	0	3	3	3	0	4	6			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr19:29698963C>G	uc002nsd.2	-	2	428	c.317G>C	c.(316-318)AGC>ACC	p.S106T		NM_006003	NP_005994	P47985	UCRI_HUMAN	ubiquinol-cytochrome c reductase, Rieske	106					respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity				0	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)			AGCCTCGCTGCTTTCTCTTGA	0.478													3	115					0	0	0	0	G	29698963	G	G	29698963	3	3	202	1	0	0	0	0	1	0	0	0	17089	797	28	4	511	4	UQCRFS1	19	29698963	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	16701092	29698963	29430020	63	37105											
LSR	51599	broad.mit.edu	37	chr19	35757786	35757811	+	Frame_Shift_Del	DEL	ATGCGGGTCCTGTACTACATGGAGAA	-	-																															ccagccagcaggacgactccAtgcgggtcctgtactacatg																								rs35205867	byFrequency	TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	8cf9a8ac-789d-4269-9bb5-0a85488cdf63	g.chr19:35757786_35757811delATGCGGGTCCTGTACTACATGGAGAA	uc002nyl.2	+	8	1427_1452	c.1204_1229delATGCGGGTCCTGTACTACATGGAGAA	c.(1204-1230)ATGCGGGTCCTGTACTACATGGAGAAGfs	p.M402fs	LSR_uc002nym.2_Frame_Shift_Del_p.M383fs|LSR_uc002nyn.2_Frame_Shift_Del_p.M334fs|LSR_uc002nyo.2_Frame_Shift_Del_p.M382fs|LSR_uc010xsr.1_Frame_Shift_Del_p.M294fs|LSR_uc002nyp.2_Frame_Shift_Del_p.M344fs|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank|USF2_uc002nyv.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	402_410	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GGACGACTCCATGCGGGTCCTGTACTACATGGAGAAGGAGCTGGCC	0.637													---	---	---								-	35757811	-	-	35757786	7	5	202	1	0	1	0	1	0	0	0	0	9114	217	8	0	1234	0	LSR	19	35757786	Frame_Shift_Del	DEL	ATGCGGGTCCTGTACTACATGGAGAA	TCGA-CV-6943-01A-11D-1912-08	6058823	35757786	23371197	64	37106											
YIF1B	90522	broad.mit.edu	37	chr19	38799436	38799436	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccaggcctcccttacctatCctgggtccccagcgcaagac	7	7	8	19	1	0	1	0	0	0	1	3	1	3	1	7	2	2	1	7	2	3	2			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr19:38799436C>T	uc002ohz.2	-	5	584	c.535G>A	c.(535-537)GAT>AAT	p.D179N	YIF1B_uc002ohw.2_Missense_Mutation_p.D148N|YIF1B_uc002ohx.2_Missense_Mutation_p.D164N|YIF1B_uc010xtx.1_Missense_Mutation_p.D162N|YIF1B_uc010xty.1_Missense_Mutation_p.D148N|YIF1B_uc002oia.2_Missense_Mutation_p.D176N|YIF1B_uc002ohy.2_Missense_Mutation_p.D176N|YIF1B_uc002oib.2_Missense_Mutation_p.D176N	NM_001039672	NP_001034761	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B isoform 5	179	Extracellular (Potential).					integral to membrane					0	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCTTACCTATCCTGGGTCCCC	0.567													9	248					0	0	0	0	T	38799436	T	T	38799436	3	4	202	1	0	0	0	0	1	0	0	0	17544	855	30	2	506	2	YIF1B	19	38799436	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	3041650	38799436	20329547	65	37107											
GLTSCR2	29997	broad.mit.edu	37	chr19	48253511	48253511	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cttcgggttgacctcatcctCgagaacacatccaaagtccc	10	9	7	15	2	1	2	1	1	0	1	6	3	4	2	4	1	1	1	4	1	2	2	rs148201586		TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr19:48253511C>G	uc002phm.2	+	3	390	c.366C>G	c.(364-366)CTC>CTG	p.L122L	GLTSCR2_uc002phk.2_Silent_p.L122L|GLTSCR2_uc002phl.2_Silent_p.L122L|GLTSCR2_uc010elj.2_Silent_p.L122L|GLTSCR2_uc010elk.1_5'Flank	NM_015710	NP_056525	Q9NZM5	GSCR2_HUMAN	glioma tumor suppressor candidate region gene 2	122						nucleolus				central_nervous_system(1)	1		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)		ACCTCATCCTCGAGAACACAT	0.522													3	50					0	0	0	0	G	48253511	G	G	48253511	2	3	202	1	0	0	0	0	0	0	0	1	6512	871	31	3		3	GLTSCR2	19	48253511	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08	9454075	48253511	10875472	66	37108											
TSEN34	79042	broad.mit.edu	37	chr19	54695773	54695773	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaggctgccaaagaggatGagaccagtgatggccaggct	11	5	15	10	0	0	3	0	2	0	2	0	5	0	4	4	4	1	2	4	4	1	0			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr19:54695773G>A	uc002qdu.2	+	3	554	c.445G>A	c.(445-447)GAG>AAG	p.E149K	MBOAT7_uc002qdq.2_5'Flank|MBOAT7_uc002qdr.2_5'Flank|MBOAT7_uc002qds.2_5'Flank|MBOAT7_uc010yen.1_5'Flank|MBOAT7_uc002qdt.3_5'Flank|TSEN34_uc010yeo.1_Missense_Mutation_p.E149K|TSEN34_uc002qdv.2_Missense_Mutation_p.E149K|TSEN34_uc002qdw.2_Missense_Mutation_p.E149K	NM_024075	NP_076980	Q9BSV6	SEN34_HUMAN	tRNA-intron endonuclease 34	149					mRNA processing|tRNA-type intron splice site recognition and cleavage	nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity				0	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CAAAGAGGATGAGACCAGTGA	0.597													16	69					0	0	0	0	A	54695773	A	A	54695773	3	1	202	1	0	0	0	0	1	0	0	0	16680	1291	45	2	451	2	TSEN34	19	54695773	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08	6442262	54695773	4433210	67	37109											
ProSAPiP1	9762	broad.mit.edu	37	chr20	3147473	3147473	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctgccaaccacgttgcCacagacatcggtgtggtcac	8	8	11	14	2	1	1	1	0	0	1	2	1	1	1	3	2	4	3	3	2	1	1			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr20:3147473C>T	uc002wia.1	-	1	1735	c.337G>A	c.(337-339)GGC>AGC	p.G113S	ProSAPiP1_uc002wib.1_Missense_Mutation_p.G113S	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	113						cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						ACCACGTTGCCACAGACATCG	0.652													5	49					0	0	0	0	T	3147473	T	T	3147473	3	4	202	1	0	0	0	0	1	0	0	0	12935	594	21	4	1696	4	ProSAPiP1	20	3147473	Missense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08		3147473	59878047	68	37110											
EP300	2033	broad.mit.edu	37	chr22	41513521	41513521	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catggggatgggcactagtgGaccaaatcagggtcctacgc	10	7	14	10	1	1	0	1	0	0	0	2	2	2	2	2	5	1	1	2	5	3	2			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr22:41513521G>T	uc003azl.3	+	2	820	c.425G>T	c.(424-426)GGA>GTA	p.G142V		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	142					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGCACTAGTGGACCAAATCAG	0.493			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				6	40					5.9392e-07	3.04203e-06	1	0	T	41513521	T	T	41513521	3	4	202	1	0	0	0	0	1	0	0	0	5172	1174	41	2	431	2	EP300	22	41513521	Missense_Mutation	SNP	G	TCGA-CV-6943-01A-11D-1912-08		41513521	9791045	69	37111											
PKDREJ	10343	broad.mit.edu	37	chr22	46656522	46656522	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattgtagaaatgggaccatTtgcagacagaccaggaacac	15	7	10	9	0	0	3	0	0	0	3	0	5	0	5	2	2	2	2	2	2	3	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chr22:46656522T>C	uc003bhh.2	-	1	2698	c.2698A>G	c.(2698-2700)AAT>GAT	p.N900D		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	900	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATGGGACCATTTGCAGACAGA	0.403													12	91					0	0	0	0	C	46656522	C	C	46656522	3	2	202	1	0	0	0	0	1	0	0	0	12025	1841	64	5	4067	5	PKDREJ	22	46656522	Missense_Mutation	SNP	T	TCGA-CV-6943-01A-11D-1912-08	5143001	46656522	4648044	70	37112											
OFD1	8481	broad.mit.edu	37	chrX	13762639	13762639	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atttaacagagattctctggGtaattatagccttctttctt	10	18	6	7	0	3	1	0	0	3	1	4	2	3	1	1	1	2	1	1	1	4	9			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chrX:13762639G>T	uc004cvp.3	+	6	876	c.517_splice	c.e6+1	p.A173_splice	OFD1_uc004cvr.3_Splice_Site|OFD1_uc011mil.1_Splice_Site|OFD1_uc004cvq.3_Splice_Site_p.A33_splice|OFD1_uc010nen.2_Splice_Site_p.A172_splice|OFD1_uc004cvs.3_Splice_Site|OFD1_uc004cvu.3_Splice_Site_p.A172_splice|OFD1_uc004cvv.3_Splice_Site_p.A172_splice|OFD1_uc010neo.1_5'Flank	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1						cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						GATTCTCTGGGTAATTATAGC	0.323													3	11					6.4e-05	0.000316235	1	0	T	13762639	T	T	13762639	5	4	202	1	0	0	0	0	0	0	1	0	10892	1275	44	4	540	4	OFD1	23	13762639	Splice_Site	SNP	G	TCGA-CV-6943-01A-11D-1912-08		13762639	141507921	71	37113											
TAF7L	54457	broad.mit.edu	37	chrX	100524182	100524182	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccacgccaatggctctcctCacttcttcagaaaacgctgc	9	9	7	16	2	4	1	2	0	2	1	5	1	4	1	3	1	2	2	3	1	3	2			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chrX:100524182C>T	uc004ehb.2	-	13	1400	c.1388G>A	c.(1387-1389)TGA>TAA	p.*463*	TAF7L_uc004eha.2_Silent_p.*303*	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	463					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						TGGCTCTCCTCACTTCTTCAG	0.448													16	76					0	0	0	0	T	100524182	T	T	100524182	2	4	202	1	0	0	0	0	0	0	0	1	15599	837	29	2		2	TAF7L	23	100524182	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08	86761543	100524182	54746378	72	37114											
RGAG1	57529	broad.mit.edu	37	chrX	109694739	109694739	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggggaatacctaccccgctCatgtcagatctagactctgg	9	9	11	12	1	4	2	2	0	2	2	4	3	4	3	3	3	2	1	3	3	4	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chrX:109694739C>G	uc004eor.1	+	3	1140	c.894C>G	c.(892-894)CTC>CTG	p.L298L	RGAG1_uc011msr.1_Silent_p.L298L	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	298										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CTACCCCGCTCATGTCAGATC	0.488													3	115					0	0	0	0	G	109694739	G	G	109694739	2	3	202	1	0	0	0	0	0	0	0	1	13339	813	29	2		2	RGAG1	23	109694739	Silent	SNP	C	TCGA-CV-6943-01A-11D-1912-08	9170557	109694739	45575821	73	37115											
CNGA2	1260	broad.mit.edu	37	chrX	150911102	150911102	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acattgcggacctcttcatcCgattgcgcacaggtcagtga	9	10	10	12	3	3	1	2	1	1	0	4	3	4	2	2	2	2	1	2	2	0	3			TCGA-CV-6943-01A-11D-1912-08	TCGA-CV-6943-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa37ade-3451-406d-b0bb-e135e1591b70	64d13ef2-c7a1-4a8c-866b-3b0c513019e5	g.chrX:150911102C>T	uc004fey.1	+	6	801	c.577C>T	c.(577-579)CGA>TGA	p.R193*		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	193	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCTTCATCCGATTGCGCAC	0.502													20	57					0	0	0	0	T	150911102	T	T	150911102	4	4	202	1	0	0	0	0	0	1	0	0	3612	644	23	1	595	1	CNGA2	23	150911102	Nonsense_Mutation	SNP	C	TCGA-CV-6943-01A-11D-1912-08	41216363	150911102	4359458	74	37116											
PLEKHM2	23207	broad.mit.edu	37	chr1	16051962	16051962	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctctgacaccacccccgTgcacaccacctctcaggaga	9	6	6	20	1	2	2	1	1	2	1	4	3	3	2	6	1	1	1	6	1	0	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:16051962T>C	uc010obo.1	+	8	1090	c.863T>C	c.(862-864)GTG>GCG	p.V288A		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	288	Interaction with KIF5B.				Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ACCACCCCCGTGCACACCACC	0.672													2	5					0	0	0	0	C	16051962	C	C	16051962	3	2	203	1	0	0	0	0	1	0	0	0	12136	1696	59	5	893	5	PLEKHM2	1	16051962	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08		16051962	233198659	1	37117											
RAP1GAP	5909	broad.mit.edu	37	chr1	21940122	21940122	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcggagcggagacctcaccTttgccatctggacaacatta	11	8	10	12	2	2	1	1	0	1	1	2	4	2	3	3	3	4	0	3	3	2	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:21940122T>A	uc001bex.2	-	9	731	c.473A>T	c.(472-474)AAG>ATG	p.K158M	RAP1GAP_uc001bev.2_Missense_Mutation_p.K158M|RAP1GAP_uc001bew.2_Missense_Mutation_p.K222M|RAP1GAP_uc001bey.2_Missense_Mutation_p.K158M	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	158					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		AGACCTCACCTTTGCCATCTG	0.597													27	102					0	0	0	0	A	21940122	A	A	21940122	3	1	203	1	0	0	0	0	1	0	0	0	13102	1623	56	5	1664	5	RAP1GAP	1	21940122	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08	5888160	21940122	227310499	2	37118											
NRD1	4898	broad.mit.edu	37	chr1	52305985	52305985	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtatcaagatcatcatcatgTtcatcatcaaactcatcttc	13	14	3	11	0	9	1	8	0	1	1	10	1	9	1	0	0	1	2	0	0	3	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:52305985T>C	uc001ctc.3	-	2	865	c.543A>G	c.(541-543)GAA>GAG	p.E181E	NRD1_uc009vzb.2_5'UTR|NRD1_uc001ctd.3_Silent_p.E181E|NRD1_uc001cte.2_Silent_p.E49E|NRD1_uc001ctf.2_Silent_p.E181E|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Silent_p.E49E|NRD1_uc001ctg.1_5'Flank	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						catcatcatgttcatcatcaa	0.154													6	15					0	0	0	0	C	52305985	C	C	52305985	2	2	203	1	0	0	0	0	0	0	0	1	10699	1722	60	5		5	NRD1	1	52305985	Silent	SNP	T	TCGA-CV-6945-01A-11D-1912-08	30365863	52305985	196944636	3	37119											
BARHL2	343472	broad.mit.edu	37	chr1	91182551	91182551	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccgggggctccatggtgaCtgagataggagaagaaggcg	10	6	17	8	2	0	4	0	2	0	3	2	6	2	4	2	5	0	1	2	5	3	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:91182551C>A	uc001dns.2	-	1	244	c.202G>T	c.(202-204)GTC>TTC	p.V68F		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	68						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		TCCATGGTGACTGAGATAGGA	0.542													5	52					0.000602214	0.00133419	1	0	A	91182551	A	A	91182551	3	1	203	1	0	0	0	0	1	0	0	0	1316	565	20	4	973	4	BARHL2	1	91182551	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	38876566	91182551	158068070	4	37120											
ZNF644	84146	broad.mit.edu	37	chr1	91404033	91404033	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggacacgatttcttctcaaGagacaaatcagtccaatgaa	16	9	7	9	1	3	2	2	1	2	1	5	5	4	3	1	1	0	0	1	1	4	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:91404033G>A	uc001dnw.2	-	3	3020	c.2878C>T	c.(2878-2880)CTT>TTT	p.L960F	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.L960F	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	960					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TTCTTCTCAAGAGACAAATCA	0.398													13	47					0	0	0	0	A	91404033	A	A	91404033	3	1	203	1	0	0	0	0	1	0	0	0	18127	942	33	2	1121	2	ZNF644	1	91404033	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	221482	91404033	157846588	5	37121											
AMY2B	280	broad.mit.edu	37	chr1	104115830	104115830	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggatgggattttaatgatgGtaaatgtaaaactggaagtg	14	13	13	1	0	0	1	0	1	0	0	0	4	0	4	0	4	1	2	0	4	6	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:104115830G>C	uc001duq.2	+	5	1077	c.461G>C	c.(460-462)GGT>GCT	p.G154A	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.G154A|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	154					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TTTAATGATGGTAAATGTAAA	0.408													64	542					0	0	0	0	C	104115830	C	C	104115830	3	2	203	1	0	0	0	0	1	0	0	0	595	1261	44	4	471	4	AMY2B	1	104115830	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	12711797	104115830	145134791	6	37122											
GJA8	2703	broad.mit.edu	37	chr1	147381094	147381095	+	Missense_Mutation	DNP	GC	AA	AA																															tggagggcgaggggccgcctGcagaggagggagccgaaccc																										TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:147381094_147381095GC>AA	uc001epu.1	+	2	1075_1076	c.1012_1013GC>AA	c.(1012-1014)GCA>AAA	p.A338K		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	338	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					GGGGCCGCCTGCAGAGGAGGGA	0.653													4	5					0	0	0	0	AA	147381095	AA	AA	147381094	3	1	203	1	0	0	0	0	1	0	0	0	6442	1319	46	4	1014	4	GJA8	1	147381094	Missense_Mutation	DNP	GC	TCGA-CV-6945-01A-11D-1912-08	43265264	147381094	101869527	7	37123											
IQGAP3	128239	broad.mit.edu	37	chr1	156518471	156518471	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccactgcggggttcctcAacacccgctcagtctgggct	5	8	13	15	2	3	0	2	0	1	0	4	0	4	0	3	4	2	3	3	4	1	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:156518471A>T	uc001fpf.2	-	17	1970	c.1895T>A	c.(1894-1896)TTG>TAG	p.L632*		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	632					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGGTTCCTCAACACCCGCTC	0.597													11	48					0	0	0	0	T	156518471	T	T	156518471	4	4	203	1	0	0	0	0	0	1	0	0	7855	131	5	5	3088	5	IQGAP3	1	156518471	Nonsense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08	9137377	156518471	92732150	8	37124											
CCDC19	25790	broad.mit.edu	37	chr1	159842919	159842919	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccctgtggcctttttctcCtcctccagccgctccttctc	1	14	6	20	2	2	0	0	0	2	0	7	0	5	0	7	1	1	1	7	1	0	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:159842919C>T	uc001fui.2	-	11	1410	c.1392G>A	c.(1390-1392)GAG>GAA	p.E464E	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Silent_p.E379E|CCDC19_uc001ful.2_Silent_p.E379E	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	464	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			CCTTTTTCTCCTCCTCCAGCC	0.587													16	31					0	0	0	0	T	159842919	T	T	159842919	2	4	203	1	0	0	0	0	0	0	0	1	2808	680	24	4		4	CCDC19	1	159842919	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	3324448	159842919	89407702	9	37125											
RABIF	5877	broad.mit.edu	37	chr1	202850116	202850116	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcccctcagttactcatggGaaactcgttccaaggccaca	10	9	7	15	1	2	0	2	0	0	0	5	1	4	1	4	2	2	2	4	2	3	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:202850116G>A	uc001gyl.2	-	2	399	c.362C>T	c.(361-363)TCC>TTC	p.S121F		NM_002871	NP_002862	P47224	MSS4_HUMAN	RAB-interacting factor	121					cellular membrane fusion|protein transport|small GTPase mediated signal transduction		guanyl-nucleotide exchange factor activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			TTACTCATGGGAAACTCGTTC	0.478													18	81					0	0	0	0	A	202850116	A	A	202850116	3	1	203	1	0	0	0	0	1	0	0	0	13034	1174	41	2	13	2	RABIF	1	202850116	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	43007197	202850116	46400505	10	37126											
KMO	8564	broad.mit.edu	37	chr1	241729888	241729888	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttccagaaatactttcCggatgccatccctctaattg	9	15	5	12	1	2	1	0	0	2	1	5	2	5	2	4	1	2	0	4	1	3	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:241729888C>T	uc009xgp.2	+	9	850	c.785C>T	c.(784-786)CCG>CTG	p.P262L	KMO_uc001hyy.2_Missense_Mutation_p.P262L|KMO_uc009xgo.1_Missense_Mutation_p.P262L	NM_003679	NP_003670	O15229	KMO_HUMAN	kynurenine 3-monooxygenase	262					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			ovary(2)	2	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			AAATACTTTCCGGATGCCATC	0.353													10	69					0	0	0	0	T	241729888	T	T	241729888	3	4	203	1	0	0	0	0	1	0	0	0	8463	652	23	1	819	1	KMO	1	241729888	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	38879772	241729888	7520733	11	37127											
OR2M3	127062	broad.mit.edu	37	chr1	248366497	248366497	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtggccttcatgggaaactCtgtcatggttctcctcatct	7	14	9	11	0	6	0	3	0	3	0	7	1	6	1	2	3	1	1	2	3	1	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:248366497C>G	uc010pzg.1	+	1	128	c.128C>G	c.(127-129)TCT>TGT	p.S43C		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATGGGAAACTCTGTCATGGTT	0.547													80	210					0	0	0	0	G	248366497	G	G	248366497	3	3	203	1	0	0	0	0	1	0	0	0	11065	913	32	2	130	2	OR2M3	1	248366497	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	6636609	248366497	884124	12	37128											
OSR1	130497	broad.mit.edu	37	chr2	19553023	19553023	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtaggacttggtgaagtggcGgccacagaacttgcagacga	11	7	15	8	2	0	3	0	1	0	2	0	5	0	4	1	4	2	2	1	4	3	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:19553023G>A	uc002rdc.2	-	2	847	c.544C>T	c.(544-546)CGC>TGC	p.R182C		NM_145260	NP_660303	Q8TAX0	OSR1_HUMAN	odd-skipped related 1	182	C2H2-type 1.				chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)				GTGAAGTGGCGGCCACAGAAC	0.567													40	66					0	0	0	0	A	19553023	A	A	19553023	3	1	203	1	0	0	0	0	1	0	0	0	11347	1116	39	1	264	1	OSR1	2	19553023	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08		19553023	223646350	13	37129											
OTOF	9381	broad.mit.edu	37	chr2	26682979	26682979	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagcagcagcaggagcagcaAcagtttgaggagcagccagc	13	3	15	10	0	0	1	0	1	0	0	0	4	0	3	1	2	9	7	1	2	1	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:26682979A>G	uc002rhk.2	-	46	6035	c.5908T>C	c.(5908-5910)TTG>CTG	p.L1970L	OTOF_uc010yla.1_Intron|OTOF_uc002rhh.2_Silent_p.L1203L|OTOF_uc002rhi.2_Silent_p.L1280L|OTOF_uc002rhj.2_Intron	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1970	Poly-Leu.|Helical; (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGCAGCAACAGTTTGAGG	0.607													4	12					0	0	0	0	G	26682979	G	G	26682979	2	3	203	1	0	0	0	0	0	0	0	1	11357	40	2	5		5	OTOF	2	26682979	Silent	SNP	A	TCGA-CV-6945-01A-11D-1912-08	7129956	26682979	216516394	14	37130											
CTNNA2	1496	broad.mit.edu	37	chr2	80835424	80835424	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaagtgcagaatctgggagGagagctcattgtgtcagggg	11	8	17	5	0	3	3	2	0	1	3	3	5	3	4	0	4	2	2	0	4	2	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:80835424G>T	uc010ysh.1	+	16	2416	c.2411G>T	c.(2410-2412)GGA>GTA	p.G804V	CTNNA2_uc010yse.1_Missense_Mutation_p.G804V|CTNNA2_uc010ysf.1_Missense_Mutation_p.G804V|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysi.1_Missense_Mutation_p.G436V|CTNNA2_uc010ysj.1_Missense_Mutation_p.G133V	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	804					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AATCTGGGAGGAGAGCTCATT	0.463													15	30					2.48551e-13	6.43024e-13	1	0	T	80835424	T	T	80835424	3	4	203	1	0	0	0	0	1	0	0	0	4030	1174	41	2	2265	2	CTNNA2	2	80835424	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	54152445	80835424	162363949	15	37131											
NCKAP5	344148	broad.mit.edu	37	chr2	133543010	133543010	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggggttccttgcaggggctCcccaggtcagctgttttgca	4	12	14	11	0	1	0	1	0	0	0	3	0	3	0	3	5	3	6	3	5	0	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:133543010C>A	uc002ttp.2	-	14	1748	c.1374G>T	c.(1372-1374)GGG>GGT	p.G458G	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	458							protein binding				0						TGCAGGGGCTCCCCAGGTCAG	0.468													8	44					1.26484e-09	3.0927e-09	1	0	A	133543010	A	A	133543010	2	1	203	1	0	0	0	0	0	0	0	1	10277	842	30	2		2	NCKAP5	2	133543010	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	52707586	133543010	109656363	16	37132											
PKP4	8502	broad.mit.edu	37	chr2	159530275	159530275	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccggagcatttataaaaaggTaacctacaagaatagctctg	16	9	8	8	1	1	1	0	0	1	1	1	2	1	2	2	2	4	3	2	2	9	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:159530275T>G	uc002tzv.2	+	18	3269	c.3009_splice	c.e18+2	p.K1003_splice	PKP4_uc002tzw.2_Splice_Site_p.K1003_splice|PKP4_uc002tzx.2_Splice_Site_p.K660_splice|PKP4_uc002uaa.2_Splice_Site_p.K855_splice|uc002uab.1_Intron|PKP4_uc002uac.2_Splice_Site_p.K184_splice|PKP4_uc002uad.2_Splice_Site|PKP4_uc002uae.1_Splice_Site_p.K90_splice	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a						cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						TATAAAAAGGTAACCTACAAG	0.388										HNSCC(62;0.18)			19	34					0	0	0	0	G	159530275	G	G	159530275	5	3	203	1	0	0	0	0	0	0	1	0	12042	1652	57	5	3077	5	PKP4	2	159530275	Splice_Site	SNP	T	TCGA-CV-6945-01A-11D-1912-08	25987265	159530275	83669098	17	37133											
TANK	10010	broad.mit.edu	37	chr2	162087916	162087916	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaatctcgtaaacacttgtAtcaggacaactctggataga	15	10	7	9	1	3	1	1	0	2	1	4	3	3	3	0	2	2	2	0	2	6	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:162087916A>G	uc002ubr.1	+	7	1113	c.955A>G	c.(955-957)ATC>GTC	p.I319V	TANK_uc002ubs.2_Missense_Mutation_p.I319V	NM_004180	NP_004171	Q92844	TANK_HUMAN	TRAF interacting protein TANK isoform a	319						cytosol	metal ion binding|protein binding			ovary(1)	1						AAACACTTGTATCAGGACAAC	0.403													19	57					0	0	0	0	G	162087916	G	G	162087916	3	3	203	1	0	0	0	0	1	0	0	0	15612	449	16	5	1010	5	TANK	2	162087916	Missense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08	2557641	162087916	81111457	18	37134											
TTN	7273	broad.mit.edu	37	chr2	179428334	179428334	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctaacgccttccttatctcGtttttcaagaatgtagccct	8	16	5	12	2	3	1	1	0	2	1	5	1	4	1	3	0	2	2	3	0	5	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:179428334G>T	uc010zfg.1	-	275	75045	c.74821C>A	c.(74821-74823)CGA>AGA	p.R24941R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.R18636R|TTN_uc010zfi.1_Silent_p.R18569R|TTN_uc010zfj.1_Silent_p.R18444R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25868							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTATCTCGTTTTTCAAGA	0.463													43	129					1.00001e-27	2.80421e-27	1	0	T	179428334	T	T	179428334	2	4	203	1	0	0	0	0	0	0	0	1	16803	1153	40	3		3	TTN	2	179428334	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	17340418	179428334	63771039	19	37135											
TTN	7273	broad.mit.edu	37	chr2	179612977	179612977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggatttaagagaaagatcaGtttttaaaatgtctaagttt	16	15	8	2	0	2	2	1	0	1	2	2	4	2	3	0	1	0	2	0	1	5	7			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:179612977G>A	uc002unb.2	-	46	14374	c.14150C>T	c.(14149-14151)ACT>ATT	p.T4717I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	826							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAAAGATCAGTTTTTAAAAT	0.328													12	53					0	0	0	0	A	179612977	A	A	179612977	3	1	203	1	0	0	0	0	1	0	0	0	16803	1029	36	4	96147	4	TTN	2	179612977	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	184643	179612977	63586396	20	37136											
ASNSD1	54529	broad.mit.edu	37	chr2	190530996	190530996	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtctgatgttaactaccaGtgtttattttctgctcacgt	9	17	7	8	1	3	1	1	1	2	0	3	1	3	1	1	0	3	3	1	0	4	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:190530996G>T	uc002uqt.2	+	4	572	c.138G>T	c.(136-138)CAG>CAT	p.Q46H		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	46	Glutamine amidotransferase type-2.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			TTAACTACCAGTGTTTATTTT	0.378													32	85					8.16721e-17	2.18337e-16	1	0	T	190530996	T	T	190530996	3	4	203	1	0	0	0	0	1	0	0	0	1051	1020	36	4	140	4	ASNSD1	2	190530996	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	10918019	190530996	52668377	21	37137											
ARPP21	10777	broad.mit.edu	37	chr3	35732493	35732493	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaacaagaccagcagcaccAgaatgtaagccccatcactg	15	5	7	14	0	2	2	2	0	0	2	2	2	2	2	4	0	4	3	4	0	4	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:35732493A>T	uc003cgb.2	+	9	946	c.682A>T	c.(682-684)AGA>TGA	p.R228*	ARPP21_uc003cga.2_Nonsense_Mutation_p.R228*|ARPP21_uc011axy.1_Nonsense_Mutation_p.R228*|ARPP21_uc003cgf.2_Nonsense_Mutation_p.R64*	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	228						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CAGCAGCACCAGAATGTAAGC	0.368													9	68					0	0	0	0	T	35732493	T	T	35732493	4	4	203	1	0	0	0	0	0	1	0	0	980	180	7	5	721	5	ARPP21	3	35732493	Nonsense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08		35732493	162289937	22	37138											
CX3CR1	1524	broad.mit.edu	37	chr3	39306963	39306963	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agcaatgcatctccatcactCgtgtggtaagtaaaattgct	12	12	8	9	1	2	0	1	0	1	0	4	0	2	0	1	1	3	5	1	1	4	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:39306963C>G	uc003cjl.2	-	2	1130	c.1038G>C	c.(1036-1038)ACG>ACC	p.T346T		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	346	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CTCCATCACTCGTGTGGTAAG	0.488													43	84					0	0	0	0	G	39306963	G	G	39306963	2	3	203	1	0	0	0	0	0	0	0	1	4092	871	31	3		3	CX3CR1	3	39306963	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	3574470	39306963	158715467	23	37139											
ACY1	95	broad.mit.edu	37	chr3	52012073	52012073	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgcccatcttttaccgcgagGtgctcccactcaaccaggca	8	8	8	17	3	2	0	1	0	1	0	3	1	3	0	4	2	3	2	4	2	2	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:52012073G>T	uc011bea.1	+	2	366	c.111G>T	c.(109-111)AGG>AGT	p.R37S	ABHD14B_uc003dcn.2_Intron|ABHD14A_uc010hlz.2_Missense_Mutation_p.V86L|ABHD14A_uc003dco.2_Missense_Mutation_p.V86L	NM_000666	NP_000657	Q03154	ACY1_HUMAN	aminoacylase 1	Error:Variant_position_missing_in_Q03154_after_alignment					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	TTACCGCGAGGTGCTCCCACT	0.617													6	13					0.00198382	0.00427694	1	0	T	52012073	T	T	52012073	3	4	203	1	0	0	0	0	1	0	0	0	226	1261	44	4		4	ACY1	3	52012073	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	12705110	52012073	146010357	24	37140											
OR5H2	79310	broad.mit.edu	37	chr3	98001793	98001793	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gacagagtttgttctcacagGacttacatatcagccagagt	12	11	9	9	0	2	2	2	0	1	2	3	4	2	3	1	1	2	2	1	1	2	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:98001793G>T	uc003dsj.1	+	1	62	c.62G>T	c.(61-63)GGA>GTA	p.G21V		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G21E(1)		ovary(3)	3						GTTCTCACAGGACTTACATAT	0.413													40	172					9.39024e-22	2.5791e-21	1	0	T	98001793	T	T	98001793	3	4	203	1	0	0	0	0	1	0	0	0	11216	1174	41	2	64	2	OR5H2	3	98001793	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	45989720	98001793	100020637	25	37141											
MYH15	22989	broad.mit.edu	37	chr3	108211974	108211974	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttacagatatcaatgtcCacagatgacagcatgcctct	13	11	6	11	0	2	3	1	1	1	2	3	3	3	3	2	0	4	1	2	0	4	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:108211974C>A	uc003dxa.1	-	9	879	c.822G>T	c.(820-822)GTG>GTT	p.V274V		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	274	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TATCAATGTCCACAGATGACA	0.313													8	49					5.18039e-06	1.19387e-05	1	0	A	108211974	A	A	108211974	2	1	203	1	0	0	0	0	0	0	0	1	10087	581	21	4		4	MYH15	3	108211974	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	10210181	108211974	89810456	26	37142											
ARGFX	503582	broad.mit.edu	37	chr3	121304883	121304883	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcccaggtttggttcaggaaCcggcgattcaaattgaagaa	12	10	11	8	2	2	2	2	1	0	1	3	4	3	3	2	4	1	2	2	4	4	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:121304883C>A	uc003eef.2	+	5	479	c.384C>A	c.(382-384)AAC>AAA	p.N128K		NM_001012659	NP_001012677	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	128	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(114;0.152)		GGTTCAGGAACCGGCGATTCA	0.502													8	57					0.000274275	0.000617889	1	0	A	121304883	A	A	121304883	3	1	203	1	0	0	0	0	1	0	0	0	859	506	18	4	398	4	ARGFX	3	121304883	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	13092909	121304883	76717547	27	37143											
SLC15A2	6565	broad.mit.edu	37	chr3	121643791	121643791	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttttatcatggtgttacaGgttctaaatccccttctggt	7	18	7	9	0	3	0	1	0	2	0	4	0	4	0	2	3	1	2	2	3	4	7			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:121643791G>T	uc003eep.2	+	13	1189	c.1036_splice	c.e13-1	p.V346_splice	SLC15A2_uc011bjn.1_Splice_Site_p.V315_splice	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a						protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TGGTGTTACAGGTTCTAAATC	0.393													30	171					7.01153e-11	1.74635e-10	1	0	T	121643791	T	T	121643791	5	4	203	1	0	0	0	0	0	0	1	0	14464	1014	35	4	1085	4	SLC15A2	3	121643791	Splice_Site	SNP	G	TCGA-CV-6945-01A-11D-1912-08	338908	121643791	76378639	28	37144											
SLC7A14	57709	broad.mit.edu	37	chr3	170219002	170219002	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cactggctccggccgcagtgCcaatcaggtactccaggatc	8	7	11	15	2	1	0	1	0	0	0	4	1	3	1	4	4	2	3	4	4	2	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:170219002C>G	uc003fgz.2	-	3	753	c.437G>C	c.(436-438)GGC>GCC	p.G146A	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	146						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			GGCCGCAGTGCCAATCAGGTA	0.557													8	36					0	0	0	0	G	170219002	G	G	170219002	3	3	203	1	0	0	0	0	1	0	0	0	14760	739	26	4	1902	4	SLC7A14	3	170219002	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	48575211	170219002	27803428	29	37145											
PIK3CA	5290	broad.mit.edu	37	chr3	178948136	178948136	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgattagtaaaggagcccaaGaatgcacaaagacaagagaa	20	5	10	6	0	0	4	0	1	0	3	0	6	0	5	1	1	2	2	1	1	8	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:178948136G>A	uc003fjk.2	+	20	3065	c.2908G>A	c.(2908-2910)GAA>AAA	p.E970K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	970	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E970K(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGGAGCCCAAGAATGCACAAA	0.338		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			32	55					0	0	0	0	A	178948136	A	A	178948136	3	1	203	1	0	0	0	0	1	0	0	0	11968	943	33	2	2982	2	PIK3CA	3	178948136	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	8729134	178948136	19074294	30	37146											
ZNF141	7700	broad.mit.edu	37	chr4	367208	367208	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataggtccacaacccttactAaacataagagaattcatact	17	10	4	10	0	1	1	1	0	0	1	2	2	2	1	2	1	4	0	2	1	8	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:367208A>G	uc003gaa.2	+	5	1160	c.982A>G	c.(982-984)AAA>GAA	p.K328E	ZNF141_uc003gab.2_Intron	NM_003441	NP_003432	Q15928	ZN141_HUMAN	zinc finger protein 141	328	C2H2-type 6.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0						AACCCTTACTAAACATAAGAG	0.378													29	65					0	0	0	0	G	367208	G	G	367208	3	3	203	1	0	0	0	0	1	0	0	0	17797	363	13	5	996	5	ZNF141	4	367208	Missense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08		367208	190787068	31	37147											
HTT	3064	broad.mit.edu	37	chr4	3134446	3134446	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaccattagaaccctcacAggtaacggccagtttttcag	11	9	9	12	1	2	1	2	0	0	1	2	1	2	1	3	3	2	3	3	3	3	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:3134446A>T	uc011bvq.1	+	18	2545	c.2400A>T	c.(2398-2400)ACA>ACT	p.T800T		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	798					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GAACCCTCACAGGTAACGGCC	0.468													44	106					0	0	0	0	T	3134446	T	T	3134446	2	4	203	1	0	0	0	0	0	0	0	1	7496	202	7	5		5	HTT	4	3134446	Silent	SNP	A	TCGA-CV-6945-01A-11D-1912-08	2767238	3134446	188019830	32	37148											
ADRA2C	152	broad.mit.edu	37	chr4	3768967	3768967	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgacgagacctggtacatcCtgtcctcctgcatcggctcc	7	9	9	16	3	0	1	0	0	0	1	5	3	4	1	5	2	2	3	5	2	1	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:3768967C>T	uc003ghm.2	+	1	672	c.634C>T	c.(634-636)CTG>TTG	p.L212L	ADRA2C_uc010icx.2_Silent_p.L212L	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	212	Helical; Name=5; (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CTGGTACATCCTGTCCTCCTG	0.682													7	18					0	0	0	0	T	3768967	T	T	3768967	2	4	203	1	0	0	0	0	0	0	0	1	339	680	24	4		4	ADRA2C	4	3768967	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	634521	3768967	187385309	33	37149											
BOD1L	259282	broad.mit.edu	37	chr4	13602037	13602037	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagactttcagcacactTgatggttgttgcactggaga	10	12	11	8	0	1	4	1	2	0	2	1	5	1	4	0	2	2	4	0	2	1	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:13602037T>G	uc003gmz.1	-	10	6604	c.6487A>C	c.(6487-6489)AAG>CAG	p.K2163Q	BOD1L_uc010idr.1_Missense_Mutation_p.K1500Q	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2163							DNA binding			ovary(5)|breast(1)	6						TCAGCACACTTGATGGTTGTT	0.507													22	59					0	0	0	0	G	13602037	G	G	13602037	3	3	203	1	0	0	0	0	1	0	0	0	1486	1821	63	5	2736	5	BOD1L	4	13602037	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08	9833070	13602037	177552239	34	37150											
NSUN7	79730	broad.mit.edu	37	chr4	40752855	40752856	+	Frame_Shift_Ins	INS	-	T	T																															tccggactccgtttatgtcaINStggcagccaacatttttcag																										TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:40752855_40752856insT	uc003gvj.3	+	2	640_641	c.145_146insT	c.(145-147)ATGfs	p.M49fs	NSUN7_uc003gvh.2_Frame_Shift_Ins_p.M49fs|NSUN7_uc003gvi.3_Frame_Shift_Ins_p.M49fs	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						CGTTTATGTCATGGCAGCCAAC	0.515													---	---	---								T	40752856	T	T	40752855	7	5	203	1	0	1	1	0	0	0	0	0	10737	217	8	0	147	0	NSUN7	4	40752855	Frame_Shift_Ins	INS	-	TCGA-CV-6945-01A-11D-1912-08	27150818	40752855	150401421	35	37151											
PHOX2B	8929	broad.mit.edu	37	chr4	41747863	41747863	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actaaggcggctttggcaccGttgggtctttggagcgaaga	8	10	15	8	3	1	1	0	0	1	1	1	3	1	2	1	5	1	3	1	5	2	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:41747863G>C	uc003gwf.3	-	3	1266	c.906C>G	c.(904-906)AAC>AAG	p.N302K		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	302					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						CTTTGGCACCGTTGGGTCTTT	0.557			Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				27	65					0	0	0	0	C	41747863	C	C	41747863	3	2	203	1	0	0	0	0	1	0	0	0	11914	1136	40	3	42	3	PHOX2B	4	41747863	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	995008	41747863	149406413	36	37152											
KCTD8	386617	broad.mit.edu	37	chr4	44177041	44177041	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggtatccattgtacaggTgcttttttagaggggcgatc	7	13	15	6	1	0	1	0	0	0	1	2	2	1	1	1	5	2	3	1	5	3	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:44177041T>A	uc003gwu.2	-	2	1472	c.1188A>T	c.(1186-1188)GCA>GCT	p.A396A		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	396						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						ATTGTACAGGTGCTTTTTTAG	0.493										HNSCC(17;0.042)			41	216					0	0	0	0	A	44177041	A	A	44177041	2	1	203	1	0	0	0	0	0	0	0	1	8154	1683	59	5		5	KCTD8	4	44177041	Silent	SNP	T	TCGA-CV-6945-01A-11D-1912-08	2429178	44177041	146977235	37	37153											
FRYL	285527	broad.mit.edu	37	chr4	48550722	48550724	+	In_Frame_Del	DEL	GAA	-	-																															attacctataaaaattgcatGaagaagaagatggaggtagc																										TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:48550722_48550724delGAA	uc003gyh.1	-	40	5476_5478	c.4871_4873delTTC	c.(4870-4875)CTTCAT>CAT	p.L1624del	FRYL_uc003gyg.1_In_Frame_Del_p.L320del|FRYL_uc003gyi.1_In_Frame_Del_p.L513del|FRYL_uc003gyj.1_5'Flank	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1624					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AAAATTGCATGAAGAAGAAGATG	0.31													---	---	---								-	48550724	-	-	48550722	7	5	203	1	0	1	0	1	0	0	0	0	6098	1290	45	0	4268	0	FRYL	4	48550722	In_Frame_Del	DEL	GAA	TCGA-CV-6945-01A-11D-1912-08	4373681	48550722	142603554	38	37154											
FRAS1	80144	broad.mit.edu	37	chr4	79284715	79284715	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agctgatctccacaacactgGgagcatctgcctcaggtgcc	9	8	10	14	0	3	1	1	1	2	0	4	2	3	2	3	2	5	2	3	2	1	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:79284715G>T	uc003hlb.2	+	21	2911	c.2471G>T	c.(2470-2472)GGG>GTG	p.G824V	FRAS1_uc003hkw.2_Missense_Mutation_p.G824V	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	824	FU 9.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CACAACACTGGGAGCATCTGC	0.582													13	18					1.05317e-09	2.59093e-09	1	0	T	79284715	T	T	79284715	3	4	203	1	0	0	0	0	1	0	0	0	6076	1232	43	4	2553	4	FRAS1	4	79284715	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	30733993	79284715	111869561	39	37155											
PTPN13	5783	broad.mit.edu	37	chr4	87705662	87705662	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atatcgtaccccaaaggaaaAtgttctacttatcagataaa	17	11	5	8	1	2	1	1	0	1	1	3	2	2	2	2	1	2	2	2	1	9	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:87705662A>T	uc003hpz.2	+	38	6549	c.6069A>T	c.(6067-6069)AAA>AAT	p.K2023N	PTPN13_uc003hpy.2_Missense_Mutation_p.K2028N|PTPN13_uc003hqa.2_Missense_Mutation_p.K2004N|PTPN13_uc003hqb.2_Missense_Mutation_p.K1832N|PTPN13_uc003hqc.1_Missense_Mutation_p.K389N	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2023						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CCAAAGGAAAATGTTCTACTT	0.353													3	27					0	0	0	0	T	87705662	T	T	87705662	3	4	203	1	0	0	0	0	1	0	0	0	12845	98	4	5	6230	5	PTPN13	4	87705662	Missense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08	8420947	87705662	103448614	40	37156											
KIAA0947	23379	broad.mit.edu	37	chr5	5486871	5486871	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttgaaagaaggatttccAtctgctgtgaaaaatattag	14	13	10	4	0	1	3	0	2	1	1	2	4	2	4	1	2	1	2	1	2	6	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:5486871A>T	uc003jdm.3	+	18	6780	c.6558A>T	c.(6556-6558)CCA>CCT	p.P2186P		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2186										ovary(1)|central_nervous_system(1)	2						AAGGATTTCCATCTGCTGTGA	0.323													3	8					0	0	0	0	T	5486871	T	T	5486871	2	4	203	1	0	0	0	0	0	0	0	1	8241	204	8	5		5	KIAA0947	5	5486871	Silent	SNP	A	TCGA-CV-6945-01A-11D-1912-08		5486871	175428389	41	37157											
DNAH5	1767	broad.mit.edu	37	chr5	13708445	13708445	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgcagcctctcttttacCtgccatggagacattcaaag	9	13	7	12	0	3	1	1	0	2	1	4	2	3	1	3	1	4	1	3	1	2	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:13708445C>T	uc003jfd.2	-	76	13168	c.13126_splice	c.e76-1	p.V4376_splice	DNAH5_uc003jfc.2_Splice_Site_p.V544_splice	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTCTTTTACCTGCCATGGAG	0.463									Kartagener_syndrome				31	62					0	0	0	0	T	13708445	T	T	13708445	5	4	203	1	0	0	0	0	0	0	1	0	4626	695	24	4	765	4	DNAH5	5	13708445	Splice_Site	SNP	C	TCGA-CV-6945-01A-11D-1912-08	8221574	13708445	167206815	42	37158											
SLC38A9	153129	broad.mit.edu	37	chr5	54968452	54968452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaattctcttgttcatggcaGaggcatggtcactaaccctc	9	12	9	11	0	3	1	2	0	1	1	5	2	3	1	1	3	1	3	1	3	2	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:54968452G>A	uc003jqf.2	-	4	386	c.185C>T	c.(184-186)TCT>TTT	p.S62F	SLC38A9_uc003jqd.2_5'UTR|SLC38A9_uc010ivx.2_Missense_Mutation_p.S35F|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Intron	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	62					amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				GTTCATGGCAGAGGCATGGTC	0.413													16	61					0	0	0	0	A	54968452	A	A	54968452	3	1	203	1	0	0	0	0	1	0	0	0	14675	942	33	2	1552	2	SLC38A9	5	54968452	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	41260007	54968452	125946808	43	37159											
PCDHA1	56147	broad.mit.edu	37	chr5	140166108	140166108	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagggaccttctggaggtaaAtctgcagaatggcattttgt	10	12	12	7	0	2	1	0	0	2	1	2	3	2	3	1	4	1	3	1	4	3	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:140166108A>T	uc003lhb.2	+	1	233	c.233A>T	c.(232-234)AAT>ATT	p.N78I	PCDHA1_uc003lha.2_Missense_Mutation_p.N78I|PCDHA1_uc003lgz.2_Missense_Mutation_p.N78I	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	78	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGAGGTAAATCTGCAGAAT	0.597													37	127					0	0	0	0	T	140166108	T	T	140166108	3	4	203	1	0	0	0	0	1	0	0	0	11573	101	4	5	235	5	PCDHA1	5	140166108	Missense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08	85197656	140166108	40749152	44	37160											
PCDHA8	56140	broad.mit.edu	37	chr5	140222763	140222763	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagctgcaagcagccctcgCatcccgttccgcgtggggct	5	7	12	17	4	0	0	0	0	0	0	3	0	2	0	4	2	4	6	4	2	1	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:140222763C>A	uc003lhs.2	+	1	1857	c.1857C>A	c.(1855-1857)CGC>CGA	p.R619R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.R619R	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	619	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCCCTCGCATCCCGTTCC	0.672													48	111					1.61863e-15	4.29847e-15	1	0	A	140222763	A	A	140222763	2	1	203	1	0	0	0	0	0	0	0	1	11584	697	25	4		4	PCDHA8	5	140222763	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	56655	140222763	40692497	45	37161											
PCDHB2	56133	broad.mit.edu	37	chr5	140475707	140475707	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acataaccgtgctggtctccGacgtcaatgacaacgccccc	10	7	8	16	4	2	1	1	1	1	0	3	2	2	1	4	1	3	1	4	1	3	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:140475707G>C	uc003lil.2	+	1	1471	c.1333G>C	c.(1333-1335)GAC>CAC	p.D445H	PCDHB2_uc003lim.1_Missense_Mutation_p.D106H	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	445	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGGTCTCCGACGTCAATGA	0.607													55	136					0	0	0	0	C	140475707	C	C	140475707	3	2	203	1	0	0	0	0	1	0	0	0	11596	1058	37	3	1335	3	PCDHB2	5	140475707	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	252944	140475707	40439553	46	37162											
C5orf41	153222	broad.mit.edu	37	chr5	172517447	172517447	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgctttaacctcaaactggGaacagtgggatacatactgt	12	11	10	8	0	1	0	1	0	0	0	1	2	1	2	1	2	6	1	1	2	5	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:172517447G>A	uc003mch.2	+	4	569	c.265G>A	c.(265-267)GAA>AAA	p.E89K	C5orf41_uc003mcg.2_Missense_Mutation_p.E89K|C5orf41_uc003mcf.2_Missense_Mutation_p.E89K|C5orf41_uc011dfd.1_Missense_Mutation_p.E89K	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	89							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTCAAACTGGGAACAGTGGGA	0.413													29	34					0	0	0	0	A	172517447	A	A	172517447	3	1	203	1	0	0	0	0	1	0	0	0	2310	1175	41	2	275	2	C5orf41	5	172517447	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	32041740	172517447	8397813	47	37163											
RGS14	10636	broad.mit.edu	37	chr5	176794768	176794768	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgggtgtggaggagttgggGcagctgccacccgttgaggg	5	8	20	8	1	0	1	0	1	0	0	0	3	0	3	2	6	2	4	2	6	0	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:176794768G>T	uc003mgf.2	+	7	863	c.681G>T	c.(679-681)GGG>GGT	p.G227G	RGS14_uc003mgg.1_Silent_p.G74G|RGS14_uc003mgh.2_Silent_p.G74G|RGS14_uc003mgi.2_5'UTR	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	227					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGAGTTGGGGCAGCTGCCAC	0.711													14	49					1.67942e-08	4.0569e-08	1	0	T	176794768	T	T	176794768	2	4	203	1	0	0	0	0	0	0	0	1	13362	1190	42	4		4	RGS14	5	176794768	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	4277321	176794768	4120492	48	37164											
DNAH8	1769	broad.mit.edu	37	chr6	38820534	38820534	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcatgcaaaagactatgatcGcatcatggccgtcatatcaa	14	10	7	10	2	4	2	4	1	0	1	5	2	4	2	1	1	1	2	1	1	5	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr6:38820534G>A	uc003ooe.1	+	38	5480	c.4880G>A	c.(4879-4881)CGC>CAC	p.R1627H		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GACTATGATCGCATCATGGCC	0.378													8	30					0	0	0	0	A	38820534	A	A	38820534	3	1	203	1	0	0	0	0	1	0	0	0	4629	1087	38	1	5022	1	DNAH8	6	38820534	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08		38820534	132294533	49	37165											
THBS2	7058	broad.mit.edu	37	chr6	169648982	169648983	+	Frame_Shift_Del	DEL	CG	-	-																															cggcacgccggggtcgggccCgcggaactgcttggcgccaa																										TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr6:169648982_169648983delCG	uc003qwt.2	-	4	386_387	c.138_139delCG	c.(136-141)CGCGGGfs	p.R46fs		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	46_47	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGGTCGGGCCCGCGGAACTGCT	0.584													---	---	---								-	169648983	-	-	169648982	7	5	203	1	0	1	0	1	0	0	0	0	15920	652	23	0	3459	0	THBS2	6	169648982	Frame_Shift_Del	DEL	CG	TCGA-CV-6945-01A-11D-1912-08	130828448	169648982	1466085	50	37166											
EIF3B	8662	broad.mit.edu	37	chr7	2409186	2409186	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atattccagccagggtaaccCtgatgcagctccctaccagg	10	8	9	14	0	0	1	0	1	0	0	2	1	2	1	5	2	5	3	5	2	3	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:2409186C>A	uc003slx.2	+	10	1566	c.1483C>A	c.(1483-1485)CTG>ATG	p.L495M	EIF3B_uc003sly.2_Missense_Mutation_p.L495M|EIF3B_uc003sma.2_Missense_Mutation_p.L223M	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	495					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CAGGGTAACCCTGATGCAGCT	0.488													6	198					0.00116845	0.00256036	1	0	A	2409186	A	A	2409186	3	1	203	1	0	0	0	0	1	0	0	0	5035	680	24	4	1521	4	EIF3B	7	2409186	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08		2409186	156729477	51	37167											
IQCE	23288	broad.mit.edu	37	chr7	2618149	2618149	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggcagagaaaaggcccGatgccagttgggtgagtatg	10	8	15	8	1	1	2	0	1	1	1	1	4	1	2	2	3	1	3	2	3	3	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:2618149G>T	uc003smo.3	+	8	803	c.619G>T	c.(619-621)GAT>TAT	p.D207Y	IQCE_uc010ksm.1_Missense_Mutation_p.D207Y|IQCE_uc003sml.1_Missense_Mutation_p.D207Y|IQCE_uc011jvy.1_Missense_Mutation_p.D191Y|IQCE_uc011jvz.1_Missense_Mutation_p.D142Y|IQCE_uc003smk.3_Missense_Mutation_p.D191Y|IQCE_uc003smn.3_Missense_Mutation_p.D142Y	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	207	Potential.										0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		GAAAAGGCCCGATGCCAGTTG	0.587													28	77					1.42536e-11	3.61752e-11	1	0	T	2618149	T	T	2618149	3	4	203	1	0	0	0	0	1	0	0	0	7845	1058	37	3	649	3	IQCE	7	2618149	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	208963	2618149	156520514	52	37168											
TMEM106B	54664	broad.mit.edu	37	chr7	12263867	12263867	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcagaaagctgtatgtgatGgcttctgtgtttgtctgtct	6	18	11	6	0	4	2	1	1	3	1	4	2	4	2	0	1	1	4	0	1	2	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:12263867G>A	uc011jxk.1	+	5	697	c.297G>A	c.(295-297)ATG>ATA	p.M99I	TMEM106B_uc003ssh.2_Missense_Mutation_p.M99I	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	99	Helical; (Potential).					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		TGTATGTGATGGCTTCTGTGT	0.388													50	169					0	0	0	0	A	12263867	A	A	12263867	3	1	203	1	0	0	0	0	1	0	0	0	16087	1348	47	4	307	4	TMEM106B	7	12263867	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	9645718	12263867	146874796	53	37169											
PCLO	27445	broad.mit.edu	37	chr7	82584801	82584801	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gattactaggtggtgtctttGgcctttcccttcttctctga	4	18	9	10	0	3	1	0	1	3	0	5	2	4	1	2	3	1	0	2	3	2	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:82584801G>A	uc003uhx.2	-	5	5757	c.5468C>T	c.(5467-5469)CCA>CTA	p.P1823L	PCLO_uc003uhv.2_Missense_Mutation_p.P1823L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1754					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGGTGTCTTTGGCCTTTCCCT	0.423													43	149					0	0	0	0	A	82584801	A	A	82584801	3	1	203	1	0	0	0	0	1	0	0	0	11637	1348	47	4	10061	4	PCLO	7	82584801	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	70320934	82584801	76553862	54	37170											
ADAM22	53616	broad.mit.edu	37	chr7	87785302	87785302	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctactttagttgtgcagcaaGgaagaacattaaactgcagg	14	10	10	7	0	0	1	0	0	0	1	0	2	0	2	0	2	6	4	0	2	7	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:87785302G>T	uc003ujn.2	+	22	1967	c.1888G>T	c.(1888-1890)GGA>TGA	p.G630*	ADAM22_uc003ujk.1_Nonsense_Mutation_p.G630*|ADAM22_uc003ujl.1_Nonsense_Mutation_p.G630*|ADAM22_uc003ujm.2_Nonsense_Mutation_p.G630*|ADAM22_uc003ujo.2_Nonsense_Mutation_p.G630*|ADAM22_uc003ujp.1_Nonsense_Mutation_p.G682*	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	630	Cys-rich.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TGTGCAGCAAGGAAGAACATT	0.383													19	56					5.35267e-07	1.2626e-06	1	0	T	87785302	T	T	87785302	4	4	203	1	0	0	0	0	0	1	0	0	244	1001	35	4	1974	4	ADAM22	7	87785302	Nonsense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	5200501	87785302	71353361	55	37171											
CCDC132	55610	broad.mit.edu	37	chr7	92905483	92905483	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttctttccacagacagcaAtggatcaacttcatatgcac	12	13	5	11	0	3	1	2	0	1	1	4	2	4	2	1	1	3	2	1	1	3	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:92905483A>G	uc003umo.2	+	12	936	c.808A>G	c.(808-810)ATG>GTG	p.M270V	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.M240V|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Missense_Mutation_p.M270V	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	270											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ACAGACAGCAATGGATCAACT	0.343													26	55					0	0	0	0	G	92905483	G	G	92905483	3	3	203	1	0	0	0	0	1	0	0	0	2779	101	4	5	854	5	CCDC132	7	92905483	Missense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08	5120181	92905483	66233180	56	37172											
ASNS	440	broad.mit.edu	37	chr7	97482391	97482391	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgatgttcaacgtattccTgtaaaatcttaaaccaggaa	14	12	6	9	1	2	1	1	1	1	0	3	2	3	2	3	1	2	3	3	1	7	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:97482391T>A	uc003uot.3	-	12	1963	c.1457A>T	c.(1456-1458)CAG>CTG	p.Q486L	ASNS_uc011kin.1_Missense_Mutation_p.Q403L|ASNS_uc003uou.3_Missense_Mutation_p.Q486L|ASNS_uc003uov.3_Missense_Mutation_p.Q486L|ASNS_uc011kio.1_Missense_Mutation_p.Q465L|ASNS_uc003uow.3_Missense_Mutation_p.Q465L|ASNS_uc003uox.3_Missense_Mutation_p.Q403L	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	486	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AACGTATTCCTGTAAAATCTT	0.358													7	29					0	0	0	0	A	97482391	A	A	97482391	3	1	203	1	0	0	0	0	1	0	0	0	1050	1580	55	5	236	5	ASNS	7	97482391	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08	4576908	97482391	61656272	57	37173											
BAIAP2L1	55971	broad.mit.edu	37	chr7	97939786	97939786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatttaccctttgtgaattcGgggcagccgtggctgggtta	6	14	13	8	2	0	1	0	1	0	0	1	1	0	1	2	4	2	3	2	4	4	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:97939786G>A	uc003upj.2	-	9	1189	c.926C>T	c.(925-927)CCG>CTG	p.P309L		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	309					filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			TTGTGAATTCGGGGCAGCCGT	0.398													11	40					0	0	0	0	A	97939786	A	A	97939786	3	1	203	1	0	0	0	0	1	0	0	0	1304	1116	39	1	633	1	BAIAP2L1	7	97939786	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	457395	97939786	61198877	58	37174											
PILRB	29990	broad.mit.edu	37	chr7	99933531	99933531	+	5'Flank	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actgggaaagttccctccacGgctcccacaggcgccccgcc	7	5	10	19	3	0	0	0	0	0	0	3	1	3	1	6	3	0	2	6	3	1	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:99933531G>T	uc003uuk.2	+						PMS2L1_uc003uuh.2_RNA|PMS2L1_uc003uui.2_RNA|PMS2L1_uc010lgv.1_RNA|PILRB_uc003uul.2_5'Flank	NM_013440	NP_038468	Q9UKJ0	PILRB_HUMAN	paired immunoglobulin-like type 2 receptor beta						activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTCCCTCCACGGCTCCCACAG	0.667													5	6					0.000602214	0.00133419	1	0	T	99933531	T	T	99933531	1	4	203	0	1	0	0	0	0	0	0	0	11981	1131	39	3		3	PILRB	7	99933531	5'Flank	SNP	G	TCGA-CV-6945-01A-11D-1912-08	1993745	99933531	59205132	59	37175											
LAMB4	22798	broad.mit.edu	37	chr7	107674717	107674717	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtaatggtagagtttgccCgtccttgagtgatttgagct	7	15	13	6	1	0	4	0	3	0	1	1	4	1	4	2	1	2	4	2	1	2	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:107674717C>G	uc010ljo.1	-	31	4838	c.4754G>C	c.(4753-4755)CGG>CCG	p.R1585P	LAMB4_uc003vey.2_Missense_Mutation_p.R1585P|LAMB4_uc010ljp.1_Missense_Mutation_p.R554P	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1585	Potential.|Domain I.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						AGAGTTTGCCCGTCCTTGAGT	0.338													30	89					0	0	0	0	G	107674717	G	G	107674717	3	3	203	1	0	0	0	0	1	0	0	0	8653	652	23	3	547	3	LAMB4	7	107674717	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	7741186	107674717	51463946	60	37176											
TAS2R38	5726	broad.mit.edu	37	chr7	141673487	141673487	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggatgcgagttagagtcaaCatgatgtcacttctctaatt	11	13	9	8	2	3	2	2	1	1	1	4	4	3	3	0	1	2	1	0	1	3	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:141673487C>T	uc003vwx.1	-	1	87	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	1	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					TTAGAGTCAACATGATGTCAC	0.448													17	51					0	0	0	0	T	141673487	T	T	141673487	3	4	203	1	0	0	0	0	1	0	0	0	15641	478	17	4	1002	4	TAS2R38	7	141673487	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	33998770	141673487	17465176	61	37177											
ZNF786	136051	broad.mit.edu	37	chr7	148767797	148767797	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccctgatggctgagcagctgCgccttcaggcggaaactctt	7	9	12	13	2	2	2	1	2	1	0	2	3	2	3	2	3	4	3	2	3	1	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:148767797C>A	uc003wfh.2	-	4	2204	c.2067G>T	c.(2065-2067)GCG>GCT	p.A689A	ZNF786_uc011kuk.1_Silent_p.A652A|ZNF786_uc003wfi.2_Silent_p.A603A	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	689	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGAGCAGCTGCGCCTTCAGGC	0.557													53	141					1.39843e-22	3.86738e-22	1	0	A	148767797	A	A	148767797	2	1	203	1	0	0	0	0	0	0	0	1	18225	755	27	3		3	ZNF786	7	148767797	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	7094310	148767797	10370866	62	37178											
SLCO5A1	81796	broad.mit.edu	37	chr8	70744880	70744880	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctccagctgctctcccgccCcgggctgcagtccagtgcct	3	8	10	20	2	1	0	0	0	1	0	4	0	3	0	7	1	4	4	7	1	0	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:70744880C>A	uc003xyl.2	-	2	736	c.29G>T	c.(28-30)GGG>GTG	p.G10V	SLCO5A1_uc010lzb.2_Missense_Mutation_p.G10V|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.G10V|SLCO5A1_uc010lzc.2_Missense_Mutation_p.G10V	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	10	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CTCTCCCGCCCCGGGCTGCAG	0.617											OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	71					7.38237e-10	1.82736e-09	1	0	A	70744880	A	A	70744880	3	1	203	1	0	0	0	0	1	0	0	0	14795	623	22	4	2553	4	SLCO5A1	8	70744880	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08		70744880	75619142	63	37179											
CA2	760	broad.mit.edu	37	chr8	86385963	86385963	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggcacttacagattgattCagtttcactttcactggggt	9	15	9	8	0	3	2	3	1	0	1	3	2	3	2	0	3	1	2	0	3	1	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:86385963C>G	uc003ydk.2	+	3	454	c.274C>G	c.(274-276)CAG>GAG	p.Q92E		NM_000067	NP_000058	P00918	CAH2_HUMAN	carbonic anhydrase II	92		Activator.	Q -> P (in OPTB3; in Czechoslovakia).		one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(1)	1					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	CAGATTGATTCAGTTTCACTT	0.289													14	50					0	0	0	0	G	86385963	G	G	86385963	3	3	203	1	0	0	0	0	1	0	0	0	2528	827	29	2	284	2	CA2	8	86385963	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	15641083	86385963	59978059	64	37180											
DCAF4L2	138009	broad.mit.edu	37	chr8	88886052	88886052	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctctgcatgcagcttacacGcagctcgcgagctatacggc	8	8	10	15	4	1	0	0	0	1	0	2	1	1	0	1	1	7	6	1	1	3	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:88886052G>T	uc003ydz.2	-	1	245	c.148C>A	c.(148-150)CGT>AGT	p.R50S		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	50										ovary(1)	1						CAGCTTACACGCAGCTCGCGA	0.502													27	71					3.28513e-13	8.44446e-13	1	0	T	88886052	T	T	88886052	3	4	203	1	0	0	0	0	1	0	0	0	4289	1087	38	3	1043	3	DCAF4L2	8	88886052	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	2500089	88886052	57477970	65	37181											
ANGPT1	284	broad.mit.edu	37	chr8	108306199	108306199	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcctctttggaaatctaGacttccatcttcacgatgtt	9	14	6	12	1	4	1	1	0	3	1	5	3	5	2	3	1	1	1	3	1	2	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:108306199G>T	uc003ymn.2	-	6	1471	c.1003C>A	c.(1003-1005)CTA>ATA	p.L335I	ANGPT1_uc011lhv.1_Missense_Mutation_p.L135I|ANGPT1_uc003ymo.2_Missense_Mutation_p.L334I|ANGPT1_uc003ymp.3_Missense_Mutation_p.L134I	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	335	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TGGAAATCTAGACTTCCATCT	0.348													10	82					7.48243e-07	1.75465e-06	1	0	T	108306199	T	T	108306199	3	4	203	1	0	0	0	0	1	0	0	0	610	933	33	2	509	2	ANGPT1	8	108306199	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	19420147	108306199	38057823	66	37182											
CSMD3	114788	broad.mit.edu	37	chr8	114326998	114326998	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgccattaagtccttttaaaGttccaccacatgtataaata	14	14	4	9	0	0	0	0	0	0	0	2	0	2	0	4	0	1	2	4	0	7	7			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:114326998G>C	uc003ynu.2	-	2	362	c.203C>G	c.(202-204)ACT>AGT	p.T68S	CSMD3_uc003ynt.2_Missense_Mutation_p.T28S|CSMD3_uc011lhx.1_Missense_Mutation_p.T68S|CSMD3_uc010mcx.1_Missense_Mutation_p.T68S|CSMD3_uc003ynx.3_Missense_Mutation_p.T68S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	68	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCCTTTTAAAGTTCCACCACA	0.308										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	138					0	0	0	0	C	114326998	C	C	114326998	3	2	203	1	0	0	0	0	1	0	0	0	3963	1029	36	4	11200	4	CSMD3	8	114326998	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	6020799	114326998	32037024	67	37183											
ASAP1	50807	broad.mit.edu	37	chr8	131127924	131127924	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatctcctcctgtcgaagatTccactcatattctacgtgga	9	14	6	12	2	3	1	1	0	2	1	7	3	5	2	3	1	1	0	3	1	4	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:131127924T>C	uc003yta.1	-	22	2150	c.2122A>G	c.(2122-2124)AAT>GAT	p.N708D	ASAP1_uc003ysz.1_Missense_Mutation_p.N519D|ASAP1_uc011liw.1_Missense_Mutation_p.N701D	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	708					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TGTCGAAGATTCCACTCATAT	0.413													36	298					0	0	0	0	C	131127924	C	C	131127924	3	2	203	1	0	0	0	0	1	0	0	0	1012	1783	62	5	1299	5	ASAP1	8	131127924	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08	16800926	131127924	15236098	68	37184											
FAM135B	51059	broad.mit.edu	37	chr8	139160820	139160820	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcttccaaattttcttcctCttcctctggtgggaaatatg	8	17	6	10	0	4	0	0	0	4	0	7	1	7	1	3	2	0	0	3	2	3	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:139160820C>T	uc003yuy.2	-	14	3562	c.3391G>A	c.(3391-3393)GAG>AAG	p.E1131K	FAM135B_uc003yux.2_Missense_Mutation_p.E1032K|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.E693K|FAM135B_uc003yvb.2_Missense_Mutation_p.R658K	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1131										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTTTCTTCCTCTTCCTCTGGT	0.373										HNSCC(54;0.14)			5	23					0	0	0	0	T	139160820	T	T	139160820	3	4	203	1	0	0	0	0	1	0	0	0	5477	922	32	2	857	2	FAM135B	8	139160820	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	8032896	139160820	7203202	69	37185											
CHRAC1	54108	broad.mit.edu	37	chr8	141521631	141521631	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgtgggtaaagacaagggCggggagcagcggctcatctc	9	6	17	9	3	2	1	1	0	1	1	4	2	2	2	0	5	2	3	0	5	3	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:141521631C>A	uc003yvl.2	+	1	231	c.33C>A	c.(31-33)GGC>GGA	p.G11G	CHRAC1_uc010mem.1_RNA	NM_017444	NP_059140	Q9NRG0	CHRC1_HUMAN	chromatin accessibility complex 1	11					chromatin remodeling	chromatin accessibility complex|epsilon DNA polymerase complex	DNA-directed DNA polymerase activity|sequence-specific DNA binding			ovary(1)	1	all_cancers(97;5.52e-16)|all_epithelial(106;1.22e-13)|Lung NSC(106;4.09e-06)|all_lung(105;6e-06)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.107)			AAGACAAGGGCGGGGAGCAGC	0.697													6	7					0.00116845	0.00256036	1	0	A	141521631	A	A	141521631	2	1	203	1	0	0	0	0	0	0	0	1	3386	755	27	3		3	CHRAC1	8	141521631	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	2360811	141521631	4842391	70	37186											
RECQL4	9401	broad.mit.edu	37	chr8	145738093	145738093	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggcaatgggtataggtggtCgccagcagctccagccagtg	8	7	15	11	2	0	0	0	0	0	0	2	0	1	0	3	4	3	4	3	4	3	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:145738093C>T	uc003zdj.2	-	17	2849	c.2817G>A	c.(2815-2817)GCG>GCA	p.A939A		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	939					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TATAGGTGGTCGCCAGCAGCT	0.672			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				5	35					0	0	0	0	T	145738093	T	T	145738093	2	4	203	1	0	0	0	0	0	0	0	1	13267	871	31	1		1	RECQL4	8	145738093	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	4216462	145738093	625929	71	37187											
PSIP1	11168	broad.mit.edu	37	chr9	15478476	15478485	+	Frame_Shift_Del	DEL	TGTCACTCTC	-	-																															acattaaaaataaactcacaTgtcactctctgaaggacagg																										TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr9:15478476_15478485delTGTCACTCTC	uc003zlv.3	-	8	949_958	c.619_628delGAGAGTGACA	c.(619-630)GAGAGTGACATCfs	p.E207fs	PSIP1_uc003zlw.3_Frame_Shift_Del_p.E207fs|PSIP1_uc003zlz.3_Frame_Shift_Del_p.E207fs|PSIP1_uc003zma.3_Frame_Shift_Del_p.E198fs|PSIP1_uc003zly.2_Frame_Shift_Del_p.E207fs	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	207_210					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TAAACTCACATGTCACTCTCTGAAGGACAG	0.338													---	---	---								-	15478485	-	-	15478476	7	5	203	1	0	1	0	1	0	0	0	0	12725	1478	51	0	1029	0	PSIP1	9	15478476	Frame_Shift_Del	DEL	TGTCACTCTC	TCGA-CV-6945-01A-11D-1912-08		15478476	125734955	72	37188											
CDKN2A	1029	broad.mit.edu	37	chr9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcagctccgccactcGggcgctgcccatcatcatga	8	6	10	17	3	2	1	2	1	0	0	4	1	3	1	3	1	4	4	3	1	0	0	rs121913387		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			7	8					0	0	0	0	A	21971186	A	A	21971186	4	1	203	1	0	0	0	0	0	1	0	0	3176	1125	39	1	306	1	CDKN2A	9	21971186	Nonsense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	6492710	21971186	119242245	73	37189											
UBAP1	51271	broad.mit.edu	37	chr9	34249862	34249862	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaactgcagatgctgtcccCcagcgagcggcagtgtgtgg	7	8	15	11	2	0	2	0	1	0	1	1	3	1	2	2	2	5	3	2	2	1	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr9:34249862C>T	uc003ztx.2	+	5	1404	c.1169C>T	c.(1168-1170)CCC>CTC	p.P390L	UBAP1_uc010mka.1_Missense_Mutation_p.P426L|UBAP1_uc003zty.2_Missense_Mutation_p.P390L|UBAP1_uc011loi.1_Missense_Mutation_p.P426L|UBAP1_uc011loj.1_Missense_Mutation_p.P454L|KIF24_uc010mkb.2_Intron|UBAP1_uc003ztz.2_Missense_Mutation_p.P390L	NM_016525	NP_057609	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	390	UBA 1.					cytoplasm					0			LUSC - Lung squamous cell carcinoma(29;0.00272)			ATGCTGTCCCCCAGCGAGCGG	0.532													39	57					0	0	0	0	T	34249862	T	T	34249862	3	4	203	1	0	0	0	0	1	0	0	0	16904	623	22	4	1420	4	UBAP1	9	34249862	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	12278676	34249862	106963569	74	37190											
DBC1	1620	broad.mit.edu	37	chr9	122011377	122011377	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggcactggatggcggacCagatctctcctctcgatggc	7	8	14	12	2	2	1	0	0	2	1	5	4	3	3	2	6	0	1	2	6	0	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr9:122011377C>T	uc004bkc.2	-	3	726	c.270G>A	c.(268-270)CTG>CTA	p.L90L	DBC1_uc004bkd.2_Silent_p.L90L	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	90	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GATGGCGGACCAGATCTCTCC	0.532													16	26					0	0	0	0	T	122011377	T	T	122011377	2	4	203	1	0	0	0	0	0	0	0	1	4264	581	21	4		4	DBC1	9	122011377	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	87761515	122011377	19202054	75	37191											
FBXO18	84893	broad.mit.edu	37	chr10	5948284	5948284	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atggagtttctaagaaagctCcacggcaccatttgtctgtg	10	12	10	9	1	2	1	0	0	2	1	3	2	3	2	2	2	1	3	2	2	2	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:5948284C>T	uc001iis.2	+	3	537	c.442C>T	c.(442-444)CCA>TCA	p.P148S	FBXO18_uc001iir.2_Missense_Mutation_p.P74S|FBXO18_uc009xig.2_Missense_Mutation_p.P74S|FBXO18_uc001iit.2_Missense_Mutation_p.P199S	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	148	F-box.				DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						TAAGAAAGCTCCACGGCACCA	0.597													5	35					0	0	0	0	T	5948284	T	T	5948284	3	4	203	1	0	0	0	0	1	0	0	0	5763	855	30	2	614	2	FBXO18	10	5948284	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08		5948284	129586463	76	37192											
ITGA8	8516	broad.mit.edu	37	chr10	15760779	15760779	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acttactggtggtgtcaaacGgtatctgcctgcactgcgca	8	11	11	11	2	2	0	1	0	1	0	2	0	2	0	1	3	5	3	1	3	3	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:15760779G>T	uc001ioc.1	-	2	329	c.329C>A	c.(328-330)CCG>CAG	p.P110Q	ITGA8_uc010qcb.1_Missense_Mutation_p.P110Q	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	110	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GGTGTCAAACGGTATCTGCCT	0.597													36	78					4.3181e-19	1.16997e-18	1	0	T	15760779	T	T	15760779	3	4	203	1	0	0	0	0	1	0	0	0	7921	1116	39	3	2978	3	ITGA8	10	15760779	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	9812495	15760779	119773968	77	37193											
CUBN	8029	broad.mit.edu	37	chr10	16918894	16918894	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgtcattatggctactcAcagattatcctataggaaaa	13	13	6	9	0	3	1	2	0	1	1	4	2	4	2	1	2	1	1	1	2	7	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:16918894A>T	uc001ioo.2	-	57	9158	c.9106_splice	c.e57+1	p.S3036_splice	CUBN_uc009xjq.1_Splice_Site|CUBN_uc009xjr.1_Splice_Site_p.S392_splice	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGGCTACTCACAGATTATCC	0.418													10	53					0	0	0	0	T	16918894	T	T	16918894	5	4	203	1	0	0	0	0	0	0	1	0	4068	173	6	5	1807	5	CUBN	10	16918894	Splice_Site	SNP	A	TCGA-CV-6945-01A-11D-1912-08	1158115	16918894	118615853	78	37194											
ZNF365	22891	broad.mit.edu	37	chr10	64159517	64159517	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caggcccaaaatggctaaaaAaaagccaacagccattgtga	18	5	8	10	0	0	1	0	1	0	0	0	1	0	1	3	2	3	1	3	2	7	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:64159517A>G	uc001jly.3	+	5	1300	c.1238A>G	c.(1237-1239)AAA>AGA	p.K413R	ZNF365_uc001jmb.3_Intron|ZNF365_uc001jmc.2_Intron|ZNF365_uc001jlz.3_Missense_Mutation_p.K398R|ZNF365_uc001jma.3_RNA	NM_014951	NP_055766	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform A	Error:Variant_position_missing_in_Q70YC4_after_alignment										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					ATGGCTAAAAAAAAGCCAACA	0.517													9	35					0	0	0	0	G	64159517	G	G	64159517	3	3	203	1	0	0	0	0	1	0	0	0	17936	14	1	5	1207	5	ZNF365	10	64159517	Missense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08	47240623	64159517	71375230	79	37195											
TBC1D12	23232	broad.mit.edu	37	chr10	96162460	96162460	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaccccgtgggccaggacagGaaggtaatccgggccacggg	9	3	17	12	3	0	0	0	0	0	0	1	3	1	2	5	6	0	1	5	6	2	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:96162460G>A	uc001kjr.2	+	1	275	c.90G>A	c.(88-90)AGG>AGA	p.R30R		NM_015188	NP_056003	O60347	TBC12_HUMAN	TBC1 domain family, member 12	30						intracellular	Rab GTPase activator activity				0		Colorectal(252;0.0429)				GCCAGGACAGGAAGGTAATCC	0.562													3	5					0	0	0	0	A	96162460	A	A	96162460	2	1	203	1	0	0	0	0	0	0	0	1	15667	1165	41	2		2	TBC1D12	10	96162460	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	32002943	96162460	39372287	80	37196											
GLRX3	10539	broad.mit.edu	37	chr10	131973264	131973264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcctgttgtttctttaggttCggcaaggattaaaagcttac	9	16	9	7	1	1	0	0	0	1	0	3	1	2	1	1	3	2	5	1	3	5	7			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:131973264C>T	uc001lkm.1	+	10	890	c.868C>T	c.(868-870)CGG>TGG	p.R290W	GLRX3_uc001lkn.1_Missense_Mutation_p.R290W|GLRX3_uc001lko.2_RNA	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3	290	Glutaredoxin 2.				cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		TCTTTAGGTTCGGCAAGGATT	0.428													10	53					0	0	0	0	T	131973264	T	T	131973264	3	4	203	1	0	0	0	0	1	0	0	0	6498	875	31	1	906	1	GLRX3	10	131973264	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	35810804	131973264	3561483	81	37197											
DPYSL4	10570	broad.mit.edu	37	chr10	134014379	134014379	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgacaggcagcgcccactgCaccttcaccactgcccagaa	10	5	9	17	1	1	2	1	1	0	1	1	2	1	2	4	1	3	2	4	1	1	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:134014379C>T	uc009ybb.2	+	10	1156	c.1002C>T	c.(1000-1002)TGC>TGT	p.C334C		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	334					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GCGCCCACTGCACCTTCACCA	0.647													6	15					0	0	0	0	T	134014379	T	T	134014379	2	4	203	1	0	0	0	0	0	0	0	1	4771	718	25	4		4	DPYSL4	10	134014379	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	2041115	134014379	1520368	82	37198											
OR5A2	219981	broad.mit.edu	37	chr11	59190241	59190241	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggacaggttactgaggaaGaagtacatgggcatgtgcag	14	7	15	5	0	0	2	0	1	0	1	0	4	0	4	0	4	3	4	0	4	5	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr11:59190241G>A	uc010rkt.1	-	1	186	c.186C>T	c.(184-186)TTC>TTT	p.F62F		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TACTGAGGAAGAAGTACATGG	0.493													21	70					0	0	0	0	A	59190241	A	A	59190241	2	1	203	1	0	0	0	0	0	0	0	1	11194	933	33	2		2	OR5A2	11	59190241	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08		59190241	75816275	83	37199											
OR5A1	219982	broad.mit.edu	37	chr11	59211053	59211053	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcccccttctctaccccactAtcatgacccagggcctctgt	6	10	6	19	0	3	1	1	1	2	0	4	1	3	1	6	1	1	0	6	1	2	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr11:59211053A>G	uc001nnx.1	+	1	412	c.412A>G	c.(412-414)ATC>GTC	p.I138V		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						CTACCCCACTATCATGACCCA	0.542													35	292					0	0	0	0	G	59211053	G	G	59211053	3	3	203	1	0	0	0	0	1	0	0	0	11193	449	16	5	414	5	OR5A1	11	59211053	Missense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08	20812	59211053	75795463	84	37200											
NPAS4	266743	broad.mit.edu	37	chr11	66192686	66192686	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcagcattcccctatgatggGtttactgatgagttgcatca	9	14	9	9	0	2	3	2	3	0	0	3	3	3	3	2	1	3	4	2	1	2	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr11:66192686G>A	uc001ohx.1	+	7	2501	c.2325G>A	c.(2323-2325)GGG>GGA	p.G775G	NPAS4_uc010rpc.1_Silent_p.G565G	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	775					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CCTATGATGGGTTTACTGATG	0.398													18	42					0	0	0	0	A	66192686	A	A	66192686	2	1	203	1	0	0	0	0	0	0	0	1	10619	1248	44	4		4	NPAS4	11	66192686	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	6981633	66192686	68813830	85	37201											
B3GAT1	27087	broad.mit.edu	37	chr11	134253871	134253871	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggttgggcacgtgcagcagCgtgttggccatgcgcgtcag	6	8	17	10	4	1	0	1	0	0	0	1	0	1	0	1	3	4	5	1	3	0	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr11:134253871C>T	uc001qhq.2	-	4	585	c.324G>A	c.(322-324)ACG>ACA	p.T108T	B3GAT1_uc001qhr.2_Silent_p.T108T|B3GAT1_uc010scv.1_Silent_p.T121T	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	108	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		CGTGCAGCAGCGTGTTGGCCA	0.716													10	7					0	0	0	0	T	134253871	T	T	134253871	2	4	203	1	0	0	0	0	0	0	0	1	1255	755	27	1		1	B3GAT1	11	134253871	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	68061185	134253871	752645	86	37202											
USP5	8078	broad.mit.edu	37	chr12	6970679	6970679	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcactgccagaactggttcGggcccaggtgcccttcagct	6	8	13	14	1	1	1	1	0	0	1	2	1	1	1	3	4	4	3	3	4	1	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:6970679G>A	uc001qri.3	+	13	1630	c.1571G>A	c.(1570-1572)CGG>CAG	p.R524Q	USP5_uc001qrh.3_Missense_Mutation_p.R524Q	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	524					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						GAACTGGTTCGGGCCCAGGTG	0.607													51	67					0	0	0	0	A	6970679	A	A	6970679	3	1	203	1	0	0	0	0	1	0	0	0	17149	1116	39	1	1621	1	USP5	12	6970679	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08		6970679	126881216	87	37203											
ATN1	1822	broad.mit.edu	37	chr12	7046365	7046365	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tacggaaagagagccccgtcCccgggggcctacaagacagc	11	3	13	14	3	0	2	0	0	0	2	1	4	1	3	5	3	4	0	5	3	4	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:7046365C>G	uc001qrw.1	+	5	2172	c.1935C>G	c.(1933-1935)TCC>TCG	p.S645S	ATN1_uc001qrx.1_Silent_p.S645S	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	645					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GAGCCCCGTCCCCGGGGGCCT	0.672													12	47					0	0	0	0	G	7046365	G	G	7046365	2	3	203	1	0	0	0	0	0	0	0	1	1113	610	22	4		4	ATN1	12	7046365	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	75686	7046365	126805530	88	37204											
SLC2A14	144195	broad.mit.edu	37	chr12	7973851	7973851	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatagtattaaccacacccGcgctgatggtggcatagatg	12	9	11	9	2	0	3	0	1	0	2	0	3	0	3	2	2	1	3	2	2	4	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:7973851G>A	uc001qtk.2	-	13	1797	c.1004C>T	c.(1003-1005)GCG>GTG	p.A335V	SLC2A14_uc001qtl.2_Missense_Mutation_p.A312V|SLC2A14_uc001qtm.2_Missense_Mutation_p.A312V|SLC2A14_uc010sgg.1_Missense_Mutation_p.A226V|SLC2A14_uc001qtn.2_Missense_Mutation_p.A335V|SLC2A14_uc001qto.2_5'UTR|SLC2A14_uc010sgh.1_Missense_Mutation_p.A350V	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	335	Helical; Name=8; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		AACCACACCCGCGCTGATGGT	0.413													43	122					0	0	0	0	A	7973851	A	A	7973851	3	1	203	1	0	0	0	0	1	0	0	0	14607	1087	38	1	574	1	SLC2A14	12	7973851	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	927486	7973851	125878044	89	37205											
SLCO1B3	28234	broad.mit.edu	37	chr12	21069131	21069131	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtaccttctgctggaacaGatagtaaaacatgtaatttg	13	14	8	6	0	1	1	0	0	1	1	1	2	1	2	1	1	4	4	1	1	6	7			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:21069131G>C	uc001rek.2	+	15	2185	c.2059G>C	c.(2059-2061)GAT>CAT	p.D687H	SLCO1B3_uc001rel.2_Missense_Mutation_p.D687H|SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Intron	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	687	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TGCTGGAACAGATAGTAAAAC	0.348													19	34					0	0	0	0	C	21069131	C	C	21069131	3	2	203	1	0	0	0	0	1	0	0	0	14788	942	33	2	2113	2	SLCO1B3	12	21069131	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	13095280	21069131	112782764	90	37206											
ABCC9	10060	broad.mit.edu	37	chr12	21958120	21958120	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatggtctacttgttggtCatcaccaaagtggaaaagag	13	11	11	6	0	3	2	2	1	1	1	3	3	3	3	1	3	1	1	1	3	4	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:21958120C>A	uc001rfi.1	-	38	4658	c.4638G>T	c.(4636-4638)ATG>ATT	p.M1546I	ABCC9_uc001rfh.2_Intron|ABCC9_uc001rfj.1_Missense_Mutation_p.M1510I|ABCC9_uc001rfg.2_Intron	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1546	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.R1546H(1)		ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACTTGTTGGTCATCACCAAAG	0.438													25	56					4.26978e-12	1.09056e-11	1	0	A	21958120	A	A	21958120	3	1	203	1	0	0	0	0	1	0	0	0	59	826	29	2	157	2	ABCC9	12	21958120	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	888989	21958120	111893775	91	37207											
SLC4A8	9498	broad.mit.edu	37	chr12	51853842	51853842	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgttgcctttgtgaggctGtctccagctgttcttctctc	3	18	9	11	0	3	1	0	1	3	0	6	1	3	1	2	1	2	4	2	1	0	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:51853842G>T	uc001rys.1	+	8	1141	c.963G>T	c.(961-963)CTG>CTT	p.L321L	SLC4A8_uc010sni.1_Silent_p.L268L|SLC4A8_uc001rym.2_Silent_p.L268L|SLC4A8_uc001ryn.2_Silent_p.L268L|SLC4A8_uc001ryo.2_Silent_p.L268L|SLC4A8_uc001ryp.1_Silent_p.L268L|SLC4A8_uc010snj.1_Silent_p.L348L|SLC4A8_uc001ryq.3_Silent_p.L321L|SLC4A8_uc001ryr.2_Silent_p.L321L|SLC4A8_uc010snk.1_Silent_p.L268L	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	321	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TTGTGAGGCTGTCTCCAGCTG	0.438													36	179					6.03168e-27	1.67966e-26	1	0	T	51853842	T	T	51853842	2	4	203	1	0	0	0	0	0	0	0	1	14723	1364	48	4		4	SLC4A8	12	51853842	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	29895722	51853842	81998053	92	37208											
KRT83	3889	broad.mit.edu	37	chr12	52709747	52709747	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcctagcttggagttcaTcacctcctggtactccctga	7	11	9	14	0	2	1	2	1	0	0	4	2	4	2	4	3	2	3	4	3	2	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:52709747T>A	uc001saf.2	-	7	1255	c.1192A>T	c.(1192-1194)ATG>TTG	p.M398L		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	398	Rod.|Coil 2.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TTGGAGTTCATCACCTCCTGG	0.637													20	95					0	0	0	0	A	52709747	A	A	52709747	3	1	203	1	0	0	0	0	1	0	0	0	8536	1435	50	5	301	5	KRT83	12	52709747	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08	855905	52709747	81142148	93	37209											
LRP1	4035	broad.mit.edu	37	chr12	57532268	57532268	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agacttgcagccccaagcagTttgcctgcagagatcaaata	13	8	9	11	0	1	2	1	0	0	2	1	3	1	2	3	0	5	4	3	0	3	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:57532268T>C	uc001snd.2	+	2	560	c.94T>C	c.(94-96)TTT>CTT	p.F32L	LRP1_uc010sre.1_Missense_Mutation_p.F32L|LRP1_uc001snb.2_Missense_Mutation_p.F32L|LRP1_uc001snc.1_Missense_Mutation_p.F32L	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	32	LDL-receptor class A 1.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCCAAGCAGTTTGCCTGCAG	0.527													28	126					0	0	0	0	C	57532268	C	C	57532268	3	2	203	1	0	0	0	0	1	0	0	0	9001	1725	60	5	100	5	LRP1	12	57532268	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08	4822521	57532268	76319627	94	37210											
NR1H4	9971	broad.mit.edu	37	chr12	100955674	100955674	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccacaggtatctctgatGaatatataacacctatgttt	12	13	5	11	0	1	2	0	2	1	0	2	2	1	2	3	1	1	2	3	1	6	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:100955674G>T	uc001tht.1	+	8	1148	c.1120G>T	c.(1120-1122)GAA>TAA	p.E374*	NR1H4_uc001thp.1_Nonsense_Mutation_p.E360*|NR1H4_uc001thq.1_Nonsense_Mutation_p.E364*|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Nonsense_Mutation_p.E364*|NR1H4_uc010svk.1_Nonsense_Mutation_p.E313*|NR1H4_uc001ths.1_Nonsense_Mutation_p.E370*	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	374	Ligand-binding.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TATCTCTGATGAATATATAAC	0.333													7	33					2.7689e-08	6.64867e-08	1	0	T	100955674	T	T	100955674	4	4	203	1	0	0	0	0	0	1	0	0	10673	1291	45	2	1108	2	NR1H4	12	100955674	Nonsense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	43423406	100955674	32896221	95	37211											
APPL2	55198	broad.mit.edu	37	chr12	105600878	105600878	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatgggctccatcatggcCatttgctttctgtactgcag	7	14	9	11	0	3	0	2	0	1	0	4	0	4	0	2	2	3	4	2	2	1	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:105600878C>T	uc001tlf.1	-	8	800	c.582G>A	c.(580-582)ATG>ATA	p.M194I	APPL2_uc010swt.1_Missense_Mutation_p.M151I|APPL2_uc001tlg.1_5'UTR|APPL2_uc010swu.1_Missense_Mutation_p.M200I|APPL2_uc009zuq.2_Missense_Mutation_p.M151I	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	194	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CCATCATGGCCATTTGCTTTC	0.597													13	68					0	0	0	0	T	105600878	T	T	105600878	3	4	203	1	0	0	0	0	1	0	0	0	818	594	21	4	1468	4	APPL2	12	105600878	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	4645204	105600878	28251017	96	37212											
MYO1H	283446	broad.mit.edu	37	chr12	109849746	109849746	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctacagacttgagtttcctGgagaaattggaagagaaagt	14	10	12	5	0	0	4	0	1	0	3	1	7	1	5	1	2	1	2	1	2	4	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:109849746G>C	uc010sxn.1	+	13	1410	c.1410G>C	c.(1408-1410)CTG>CTC	p.L470L		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						myosin complex	motor activity				0						TGAGTTTCCTGGAGAAATTGG	0.433													3	10					0	0	0	0	C	109849746	C	C	109849746	2	2	203	1	0	0	0	0	0	0	0	1	10128	1335	47	4		4	MYO1H	12	109849746	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	4248868	109849746	24002149	97	37213											
SDSL	113675	broad.mit.edu	37	chr12	113872019	113872019	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtccccccgtttgaccacccCctaatatggtaaggctgacg	8	9	9	15	2	0	2	0	2	0	0	1	2	1	2	6	2	0	3	6	2	3	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:113872019C>A	uc001tvi.2	+	6	645	c.435C>A	c.(433-435)CCC>CCA	p.P145P	SDSL_uc009zwh.2_Silent_p.P145P	NM_138432	NP_612441	Q96GA7	SDSL_HUMAN	serine dehydratase-like	145					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	TTGACCACCCCCTAATATGGT	0.423													26	115					2.48779e-11	6.27425e-11	1	0	A	113872019	A	A	113872019	2	1	203	1	0	0	0	0	0	0	0	1	14041	610	22	4		4	SDSL	12	113872019	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	4022273	113872019	19979876	98	37214											
PITPNM2	57605	broad.mit.edu	37	chr12	123482024	123482024	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccttcttggagctggggtcCccggcgcctgtgtccaggat	3	10	14	14	2	1	0	0	0	1	0	3	2	3	2	5	5	1	1	5	5	0	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:123482024C>T	uc001uej.1	-	10	1459	c.1320G>A	c.(1318-1320)GGG>GGA	p.G440G	PITPNM2_uc001uek.1_Silent_p.G440G	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	440					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		AGCTGGGGTCCCCGGCGCCTG	0.662													28	87					0	0	0	0	T	123482024	T	T	123482024	2	4	203	1	0	0	0	0	0	0	0	1	12006	610	22	4		4	PITPNM2	12	123482024	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	9610005	123482024	10369871	99	37215											
PXMP2	5827	broad.mit.edu	37	chr12	133266864	133266864	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagtggcattttgtcagcActtgggaacttcctggccca	8	11	10	12	0	1	0	1	0	0	0	2	1	2	1	2	3	2	2	2	3	1	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:133266864A>T	uc001ukt.2	+	2	203	c.138A>T	c.(136-138)GCA>GCT	p.A46A	POLE_uc001uks.1_5'Flank|POLE_uc010tbq.1_5'Flank|POLE_uc009zyu.1_5'Flank|PGAM5_uc010tbr.1_RNA	NM_018663	NP_061133	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa	46	Helical; (Potential).					integral to membrane|peroxisomal membrane	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		TTTTGTCAGCACTTGGGAACT	0.512													17	72					0	0	0	0	T	133266864	T	T	133266864	2	4	203	1	0	0	0	0	0	0	0	1	12915	146	6	5		5	PXMP2	12	133266864	Silent	SNP	A	TCGA-CV-6945-01A-11D-1912-08	9784840	133266864	585031	100	37216											
FAM123A	219287	broad.mit.edu	37	chr13	25743972	25743972	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagctgcctggtgttcgcaGtggacaggtgatggtgcctg	6	10	16	9	1	0	1	0	1	0	0	1	2	0	2	2	4	3	3	2	4	1	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr13:25743972G>T	uc001uqb.2	-	1	1886	c.1786C>A	c.(1786-1788)CTG>ATG	p.L596M	FAM123A_uc001uqa.2_Missense_Mutation_p.L477M|FAM123A_uc001uqc.2_Missense_Mutation_p.L477M	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	596										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GGTGTTCGCAGTGGACAGGTG	0.572													60	58					1.53582e-20	4.18956e-20	1	0	T	25743972	T	T	25743972	3	4	203	1	0	0	0	0	1	0	0	0	5450	1020	36	4	233	4	FAM123A	13	25743972	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08		25743972	89425906	101	37217											
BRCA2	675	broad.mit.edu	37	chr13	32907432	32907432	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttataaaggaaaaaaaatacCgaaagaccaaaaatcagaac	25	5	5	6	1	1	2	1	0	0	2	1	4	1	3	2	1	2	0	2	1	12	3	rs80358469		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr13:32907432C>T	uc001uub.1	+	10	2044	c.1817C>T	c.(1816-1818)CCG>CTG	p.P606L	BRCA2_uc001uua.1_Missense_Mutation_p.P483L	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	606					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAAAAAATACCGAAAGACCAA	0.318			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			6	33					0	0	0	0	T	32907432	T	T	32907432	3	4	203	1	0	0	0	0	1	0	0	0	1504	652	23	1	1851	1	BRCA2	13	32907432	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	7163460	32907432	82262446	102	37218											
LMO7	4008	broad.mit.edu	37	chr13	76393647	76393647	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctaagagaagctctaagaCgtttaaggaaatgctgcagg	14	9	12	6	1	2	2	0	0	2	2	2	4	2	3	0	2	3	4	0	2	5	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr13:76393647C>T	uc001vjv.2	+	10	2244	c.1484C>T	c.(1483-1485)ACG>ATG	p.T495M	LMO7_uc010thv.1_Missense_Mutation_p.T446M|LMO7_uc001vjt.1_Missense_Mutation_p.T394M|LMO7_uc010thw.1_Missense_Mutation_p.T345M|LMO7_uc001vjw.1_Missense_Mutation_p.T401M	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	780						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AGCTCTAAGACGTTTAAGGAA	0.388													16	38					0	0	0	0	T	76393647	T	T	76393647	3	4	203	1	0	0	0	0	1	0	0	0	8897	536	19	1	2393	1	LMO7	13	76393647	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	43486215	76393647	38776231	103	37219											
SCEL	8796	broad.mit.edu	37	chr13	78183252	78183252	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aacagaaaaaagtactgaagGgtaagatttaataagctccc	19	8	8	6	0	0	3	0	1	0	2	1	3	1	3	1	1	3	3	1	1	9	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr13:78183252G>T	uc001vki.2	+	21	1447	c.1277G>T	c.(1276-1278)GGG>GTG	p.G426V	SCEL_uc001vkj.2_Missense_Mutation_p.G406V|SCEL_uc010thx.1_Missense_Mutation_p.G384V	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	426	9.|16 X approximate tandem repeats.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		AGTACTGAAGGGTAAGATTTA	0.313													10	17					1.58986e-06	3.7066e-06	1	0	T	78183252	T	T	78183252	3	4	203	1	0	0	0	0	1	0	0	0	13953	1246	43	4	1355	4	SCEL	13	78183252	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	1789605	78183252	36986626	104	37220											
FGF14	2259	broad.mit.edu	37	chr13	102375271	102375271	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcgtcaccccaggcttcggGaccgtttccccaacatcatg	7	8	10	16	3	2	0	2	0	0	0	4	1	3	1	5	3	1	2	5	3	1	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr13:102375271G>C	uc001vpe.2	-	5	654	c.654C>G	c.(652-654)GTC>GTG	p.V218V	FGF14_uc001vpf.2_Silent_p.V223V|FGF14_uc001vpd.1_5'Flank	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	218					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CAGGCTTCGGGACCGTTTCCC	0.478													45	41					0	0	0	0	C	102375271	C	C	102375271	2	2	203	1	0	0	0	0	0	0	0	1	5875	1161	41	2		2	FGF14	13	102375271	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	24192019	102375271	12794607	105	37221											
TOX4	9878	broad.mit.edu	37	chr14	21957421	21957421	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaaagatcctaatgaaccTcagaaaccagtttcagcata	18	8	6	9	0	2	4	2	1	0	3	3	4	3	4	3	0	3	2	3	0	6	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr14:21957421T>C	uc001waz.2	+	5	772	c.669T>C	c.(667-669)CCT>CCC	p.P223P	TOX4_uc001way.2_Silent_p.P93P|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Silent_p.P200P|TOX4_uc010tlv.1_Silent_p.P93P	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	223	HMG box.					chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		CTAATGAACCTCAGAAACCAG	0.443													58	72					0	0	0	0	C	21957421	C	C	21957421	2	2	203	1	0	0	0	0	0	0	0	1	16447	1538	54	5		5	TOX4	14	21957421	Silent	SNP	T	TCGA-CV-6945-01A-11D-1912-08		21957421	85392119	106	37222											
IRF9	10379	broad.mit.edu	37	chr14	24631429	24631450	+	Frame_Shift_Del	DEL	CCCGGAGTGTGCTGGGATGATA	-	-																															aagtggagagtgggcagtttCccggagtgtgctgggatgat																								rs145197850	byFrequency	TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr14:24631429_24631450delCCCGGAGTGTGCTGGGATGATA	uc001wmq.2	+	2	203_224	c.76_97delCCCGGAGTGTGCTGGGATGATA	c.(76-99)CCCGGAGTGTGCTGGGATGATACAfs	p.P26fs	RNF31_uc001wmp.2_RNA|IRF9_uc010alj.2_5'Flank	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	26_33	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)		TGGGCAGTTTCCCGGAGTGTGCTGGGATGATACAGCTAAGAC	0.572													---	---	---								-	24631450	-	-	24631429	7	5	203	1	0	1	0	1	0	0	0	0	7876	855	30	0	78	0	IRF9	14	24631429	Frame_Shift_Del	DEL	CCCGGAGTGTGCTGGGATGATA	TCGA-CV-6945-01A-11D-1912-08	2674008	24631429	82718111	107	37223											
KCNH5	27133	broad.mit.edu	37	chr14	63246619	63246619	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggtttccttccagaagaTgtctccaaatacatcaccct	10	12	7	12	0	2	2	1	0	1	2	5	2	4	2	4	2	1	1	4	2	3	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr14:63246619T>A	uc001xfx.2	-	10	1897	c.1846A>T	c.(1846-1848)ATC>TTC	p.I616F	KCNH5_uc001xfy.2_Intron|KCNH5_uc001xfz.1_Missense_Mutation_p.I558F	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	616	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTCCAGAAGATGTCTCCAAAT	0.423													14	31					0	0	0	0	A	63246619	A	A	63246619	3	1	203	1	0	0	0	0	1	0	0	0	8074	1464	51	5	1162	5	KCNH5	14	63246619	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08	38615190	63246619	44102921	108	37224											
AKAP5	9495	broad.mit.edu	37	chr14	64936395	64936395	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataaacaatcttctacagtGacttactctccagagtcacg	14	11	5	11	1	4	2	1	1	3	1	5	2	4	2	1	0	3	0	1	0	6	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr14:64936395G>C	uc001xhd.3	+	2	1661	c.1283G>C	c.(1282-1284)TGA>TCA	p.*428S	ZBTB25_uc001xhc.2_Intron	NM_004857	NP_004848	P24588	AKAP5_HUMAN	A-kinase anchor protein 5	428					energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding				0				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		CTTCTACAGTGACTTACTCTC	0.343													11	65					0	0	0	0	C	64936395	C	C	64936395	4	2	203	1	0	0	0	0	0	0	0	0	454	1285	45	2	1285	2	AKAP5	14	64936395	Nonstop_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	1689776	64936395	42413145	109	37225											
YLPM1	56252	broad.mit.edu	37	chr14	75264441	75264441	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagtggggaatgattccccGggggccagcatctcaatttt	9	10	12	10	1	1	1	1	1	1	0	3	2	2	2	3	4	1	1	3	4	3	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr14:75264441G>A	uc001xqj.3	+	5	2565	c.2441G>A	c.(2440-2442)CGG>CAG	p.R814Q	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	619					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		ATGATTCCCCGGGGGCCAGCA	0.532													11	36					0	0	0	0	A	75264441	A	A	75264441	3	1	203	1	0	0	0	0	1	0	0	0	17554	1116	39	1	2459	1	YLPM1	14	75264441	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	10328046	75264441	32085099	110	37226											
HERC2	8924	broad.mit.edu	37	chr15	28491924	28491924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaatgtaagccacctccgCgaagtgccgccagctggtag	10	6	11	14	3	0	0	0	0	0	0	1	1	1	0	5	1	3	3	5	1	4	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:28491924C>T	uc001zbj.2	-	22	3461	c.3355G>A	c.(3355-3357)GCG>ACG	p.A1119T		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1119					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCCACCTCCGCGAAGTGCCGC	0.488													14	47					0	0	0	0	T	28491924	T	T	28491924	3	4	203	1	0	0	0	0	1	0	0	0	7097	768	27	1	11437	1	HERC2	15	28491924	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08		28491924	74039468	111	37227											
VPS39	23339	broad.mit.edu	37	chr15	42470746	42470746	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatatcgaggcaacactgcAatgatgtagggaggctggtg	12	8	14	7	1	0	1	0	1	0	0	1	3	0	2	0	4	2	4	0	4	4	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:42470746A>C	uc001zpd.2	-	10	925	c.774T>G	c.(772-774)ATT>ATG	p.I258M	VPS39_uc001zpc.2_Missense_Mutation_p.I247M	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	258	CNH.				protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		GCAACACTGCAATGATGTAGG	0.478													10	60					0	0	0	0	C	42470746	C	C	42470746	3	2	203	1	0	0	0	0	1	0	0	0	17277	126	5	5	1954	5	VPS39	15	42470746	Missense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08	13978822	42470746	60060646	112	37228											
CATSPER2	117155	broad.mit.edu	37	chr15	43927557	43927557	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gttcacatacatactcctaaCctgtcctctattttgctatg	9	16	4	12	0	2	0	1	0	1	0	4	0	4	0	3	0	4	2	3	0	5	8			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:43927557C>G	uc001zsh.2	-	10	1393	c.1178_splice	c.e10+1	p.S393_splice	STRC_uc010udz.1_5'Flank|CATSPER2_uc010bdm.2_Splice_Site|CATSPER2_uc001zsi.2_Splice_Site_p.R393_splice|CATSPER2_uc001zsj.2_Splice_Site_p.R393_splice	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2						cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		ATACTCCTAACCTGTCCTCTA	0.358											OREG0003957	type=REGULATORY REGION|Gene=AK093318|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	23	298					0	0	0	0	G	43927557	G	G	43927557	5	3	203	1	0	0	0	0	0	0	1	0	2700	521	18	4	429	4	CATSPER2	15	43927557	Splice_Site	SNP	C	TCGA-CV-6945-01A-11D-1912-08	1456811	43927557	58603835	113	37229											
CYP1A2	1544	broad.mit.edu	37	chr15	75047386	75047386	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgaccatgaagcacgcccGctgtgaacatgtccaggcgc	9	6	12	14	3	0	3	0	3	0	0	1	3	1	3	3	1	2	3	3	1	2	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:75047386G>T	uc002ayr.1	+	7	1572	c.1508G>T	c.(1507-1509)CGC>CTC	p.R503L		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	503					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	AAGCACGCCCGCTGTGAACAT	0.627													7	34					0.00307968	0.00660402	1	0	T	75047386	T	T	75047386	3	4	203	1	0	0	0	0	1	0	0	0	4167	1087	38	3	1530	3	CYP1A2	15	75047386	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	31119829	75047386	27484006	114	37230											
PLK1	5347	broad.mit.edu	37	chr16	23700835	23700835	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcaccctccttaaatatttCcgcaattacatgagcgagca	13	11	5	12	2	1	1	1	1	0	0	3	2	3	1	3	0	3	2	3	0	5	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:23700835C>T	uc002dlz.1	+	9	1499	c.1446C>T	c.(1444-1446)TTC>TTT	p.F482F		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	482					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		TTAAATATTTCCGCAATTACA	0.552													34	66					0	0	0	0	T	23700835	T	T	23700835	2	4	203	1	0	0	0	0	0	0	0	1	12149	854	30	2		2	PLK1	16	23700835	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08		23700835	66653918	115	37231											
RPGRIP1L	23322	broad.mit.edu	37	chr16	53675283	53675283	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgaaatttcctaagtcttCagttgttattgatccacttg	11	17	6	7	0	2	2	1	2	1	0	4	2	4	2	2	0	0	2	2	0	4	7			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:53675283C>T	uc002ehp.2	-	18	2852	c.2788G>A	c.(2788-2790)GAA>AAA	p.E930K	RPGRIP1L_uc002eho.3_Missense_Mutation_p.E930K|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.E930K|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.E930K|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.E930K	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	930					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				CCTAAGTCTTCAGTTGTTATT	0.403													19	47					0	0	0	0	T	53675283	T	T	53675283	3	4	203	1	0	0	0	0	1	0	0	0	13615	835	29	2	1199	2	RPGRIP1L	16	53675283	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	29974448	53675283	36679470	116	37232											
PDPR	55066	broad.mit.edu	37	chr16	70164400	70164400	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagttactggagtggagaccGataaaggacagattgaatgc	15	8	13	5	1	0	3	0	1	0	2	0	7	0	5	1	3	2	1	1	3	5	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:70164400G>T	uc002eyf.1	+	7	1639	c.682G>T	c.(682-684)GAT>TAT	p.D228Y	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.D128Y|PDPR_uc002eyg.1_5'Flank	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	228					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		AGTGGAGACCGATAAAGGACA	0.423													7	111					0.000274275	0.000617889	1	0	T	70164400	T	T	70164400	3	4	203	1	0	0	0	0	1	0	0	0	11743	1058	37	3	700	3	PDPR	16	70164400	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	16489117	70164400	20190353	117	37233											
FTSJD1	55783	broad.mit.edu	37	chr16	71319208	71319208	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtcatgatatcaccagtgtTatctggaccaaagtaccacc	12	10	8	11	0	3	1	2	1	1	0	3	2	3	2	4	2	1	2	4	2	4	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:71319208T>A	uc010cga.2	-	3	1022	c.616A>T	c.(616-618)AAC>TAC	p.N206Y	FTSJD1_uc002ezy.3_Missense_Mutation_p.N206Y|FTSJD1_uc002ezz.3_Missense_Mutation_p.N206Y	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	206						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						TCACCAGTGTTATCTGGACCA	0.428													20	60					0	0	0	0	A	71319208	A	A	71319208	3	1	203	1	0	0	0	0	1	0	0	0	6124	1754	61	5	1700	5	FTSJD1	16	71319208	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08	1154808	71319208	19035545	118	37234											
CNTNAP4	85445	broad.mit.edu	37	chr16	76496003	76496003	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggcacctattattttggagGtaagaataggtgccaggctc	10	12	12	7	0	0	1	0	0	0	1	1	2	0	2	2	5	1	3	2	5	5	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:76496003G>A	uc002feu.1	+	11	1868	c.1483_splice	c.e11+1	p.G495_splice	CNTNAP4_uc002fev.1_Splice_Site_p.G359_splice|CNTNAP4_uc010chb.1_Splice_Site_p.G422_splice|CNTNAP4_uc002fex.1_Splice_Site_p.G498_splice|CNTNAP4_uc002few.2_Splice_Site_p.G470_splice	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TATTTTGGAGGTAAGAATAGG	0.473													8	25					0	0	0	0	A	76496003	A	A	76496003	5	1	203	1	0	0	0	0	0	0	1	0	3664	1275	44	4	1531	4	CNTNAP4	16	76496003	Splice_Site	SNP	G	TCGA-CV-6945-01A-11D-1912-08	5176795	76496003	13858750	119	37235											
TP53	7157	broad.mit.edu	37	chr17	7578271	7578271	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccttccactcggataagaTgctgaggaggggccagacct	9	9	12	11	1	0	3	0	1	0	2	3	5	2	5	4	4	1	1	4	4	1	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:7578271T>A	uc002gim.2	-	6	772	c.578A>T	c.(577-579)CAT>CTT	p.H193L	TP53_uc002gig.1_Missense_Mutation_p.H193L|TP53_uc002gih.2_Missense_Mutation_p.H193L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H61L|TP53_uc010cng.1_Missense_Mutation_p.H61L|TP53_uc002gii.1_Missense_Mutation_p.H61L|TP53_uc010cnh.1_Missense_Mutation_p.H193L|TP53_uc010cni.1_Missense_Mutation_p.H193L|TP53_uc002gij.2_Missense_Mutation_p.H193L|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100L|TP53_uc002gio.2_Missense_Mutation_p.H61L|TP53_uc010vug.1_Missense_Mutation_p.H154L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	193	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> D (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(67)|p.H193L(31)|p.H193Y(26)|p.H193P(12)|p.0?(7)|p.H193D(7)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.H193H(2)|p.P191fs*53(2)|p.K164_P219del(1)|p.P191fs*15(1)|p.P191fs*6(1)|p.H100L(1)|p.H61L(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	19					0	0	0	0	A	7578271	A	A	7578271	3	1	203	1	0	0	0	0	1	0	0	0	16448	1464	51	5	716	5	TP53	17	7578271	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08		7578271	73616939	120	37236											
MPRIP	23164	broad.mit.edu	37	chr17	17078662	17078662	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttgcggacgctgctgactgGggacggcggtggggaggcca	5	6	21	9	4	0	1	0	1	0	0	0	4	0	4	1	8	2	3	1	8	0	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:17078662G>A	uc002gqu.1	+	19	2701	c.2645G>A	c.(2644-2646)GGG>GAG	p.G882E	MPRIP_uc002gqv.1_Missense_Mutation_p.G882E|MPRIP_uc002gqw.1_Missense_Mutation_p.G637E|MPRIP_uc002gqx.1_Missense_Mutation_p.G1111E|MPRIP_uc002gqy.1_Missense_Mutation_p.G1111E|MPRIP_uc010cpl.1_Intron|MPRIP_uc010cpm.1_Intron	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	882	Potential.					cytoplasm|cytoskeleton	actin binding				0						CTGCTGACTGGGGACGGCGGT	0.632													10	32					0	0	0	0	A	17078662	A	A	17078662	3	1	203	1	0	0	0	0	1	0	0	0	9796	1232	43	4	2719	4	MPRIP	17	17078662	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	9500391	17078662	64116548	121	37237											
FLII	2314	broad.mit.edu	37	chr17	18155350	18155350	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acggtagcaggagaggcaccCgctagccgcagctggttctg	8	6	15	12	3	1	1	0	0	1	1	1	2	1	1	2	4	3	7	2	4	2	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:18155350C>A	uc002gsr.1	-	11	1260	c.1209G>T	c.(1207-1209)GCG>GCT	p.A403A	FLII_uc002gsq.1_Silent_p.A275A|FLII_uc010cpy.1_Silent_p.A392A|FLII_uc010vxn.1_Silent_p.A372A|FLII_uc010vxo.1_Silent_p.A349A|FLII_uc002gss.1_Silent_p.A403A	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	403	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					GAGAGGCACCCGCTAGCCGCA	0.637													50	100					4.00472e-15	1.05651e-14	1	0	A	18155350	A	A	18155350	2	1	203	1	0	0	0	0	0	0	0	1	5957	639	23	3		3	FLII	17	18155350	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	1076688	18155350	63039860	122	37238											
C17orf66	256957	broad.mit.edu	37	chr17	34192401	34192401	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaactcttcctttggcatCtgggggttgcaagtggcaga	8	11	14	8	0	2	1	0	0	2	1	3	2	3	2	1	5	2	4	1	5	2	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:34192401C>A	uc002hke.1	-	3	288	c.139_splice	c.e3-1	p.M47_splice	C17orf66_uc010wck.1_Splice_Site|C17orf66_uc010wcl.1_Splice_Site_p.M47_splice|C17orf66_uc010wcm.1_Splice_Site_p.M13_splice	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957								binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		CCTTTGGCATCTGGGGGTTGC	0.562													13	19					0.00136819	0.00298177	1	0	A	34192401	A	A	34192401	5	1	203	1	0	0	0	0	0	0	1	0	1881	927	32	2	1626	2	C17orf66	17	34192401	Splice_Site	SNP	C	TCGA-CV-6945-01A-11D-1912-08	16037051	34192401	47002809	123	37239											
KRT13	3860	broad.mit.edu	37	chr17	39658642	39658642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctacttggcgtcctggccctCgagcaggctgcggtaggtgg	4	9	16	12	3	0	0	0	0	0	0	2	1	1	0	2	6	3	3	2	6	2	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:39658642C>T	uc002hwu.1	-	6	1291	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	KRT13_uc002hwv.1_Missense_Mutation_p.E410K|KRT13_uc002hww.2_Missense_Mutation_p.E303K|KRT13_uc010wfr.1_Missense_Mutation_p.E303K|KRT13_uc010cxo.2_Missense_Mutation_p.E410K|KRT13_uc002hwx.1_Missense_Mutation_p.E398K	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	410	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				TCCTGGCCCTCGAGCAGGCTG	0.493													40	119					0	0	0	0	T	39658642	T	T	39658642	3	4	203	1	0	0	0	0	1	0	0	0	8489	893	31	1	160	1	KRT13	17	39658642	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	5466241	39658642	41536568	124	37240											
C17orf53	78995	broad.mit.edu	37	chr17	42230139	42230145	+	Frame_Shift_Del	DEL	GCGCAAG	-	-																															tacagcattgtcatggtgctGcgcaaggtaaggattctggg																										TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:42230139_42230145delGCGCAAG	uc002ifi.1	+	5	1628_1634	c.1443_1449delGCGCAAG	c.(1441-1449)CTGCGCAAGfs	p.L481fs	C17orf53_uc010czq.1_Frame_Shift_Del_p.L481fs|C17orf53_uc002ifj.1_Intron|C17orf53_uc002ifk.1_Intron	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	481_483											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		TCATGGTGCTGCGCAAGGTAAGGATTC	0.541													---	---	---								-	42230145	-	-	42230139	7	5	203	1	0	1	0	1	0	0	0	0	1869	1306	46	0	1461	0	C17orf53	17	42230139	Frame_Shift_Del	DEL	GCGCAAG	TCGA-CV-6945-01A-11D-1912-08	2571497	42230139	38965071	125	37241											
C17orf71	55181	broad.mit.edu	37	chr17	57288460	57288460	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggaggaggacccagtaggtAtgttgctggaccaacttagg	11	8	15	7	0	0	0	0	0	0	0	0	4	0	4	2	6	2	4	2	6	4	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:57288460A>T	uc002ixi.2	+	1	1090	c.1048A>T	c.(1048-1050)ATG>TTG	p.M350L		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	350					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					CCCAGTAGGTATGTTGCTGGA	0.522													19	48					0	0	0	0	T	57288460	T	T	57288460	3	4	203	1	0	0	0	0	1	0	0	0	1885	449	16	5	1050	5	C17orf71	17	57288460	Missense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08	15058321	57288460	23906750	126	37242											
CCDC40	55036	broad.mit.edu	37	chr17	78059875	78059875	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgacgagcacgatggcaaggCggtccaggcccaggtgacct	9	4	15	13	4	0	1	0	1	0	0	1	4	1	1	3	5	1	2	3	5	1	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:78059875C>A	uc010dht.2	+	14	2336	c.2309C>A	c.(2308-2310)GCG>GAG	p.A770E	CCDC40_uc002jxm.3_Missense_Mutation_p.A553E|CCDC40_uc002jxn.3_Missense_Mutation_p.A166E	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	770	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GATGGCAAGGCGGTCCAGGCC	0.587													6	55					3.59834e-05	8.24533e-05	1	0	A	78059875	A	A	78059875	3	1	203	1	0	0	0	0	1	0	0	0	2825	768	27	3	2363	3	CCDC40	17	78059875	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	20771415	78059875	3135335	127	37243											
ZNF519	162655	broad.mit.edu	37	chr18	14106335	14106335	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacagctcccatatcttccCagtgttgcttttttgaatga	8	15	6	12	0	1	2	0	2	1	0	3	2	3	2	3	0	2	3	3	0	2	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr18:14106335C>A	uc002kst.1	-	3	357	c.204G>T	c.(202-204)CTG>CTT	p.L68L	ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	68	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATATCTTCCCAGTGTTGCTT	0.343													9	47					0.000274275	0.000617889	1	0	A	14106335	A	A	14106335	2	1	203	1	0	0	0	0	0	0	0	1	18031	581	21	4		4	ZNF519	18	14106335	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08		14106335	63970913	128	37244											
DAPK3	1613	broad.mit.edu	37	chr19	3964890	3964890	+	Frame_Shift_Del	DEL	A	-	-																															atctcctcccggctcaccccAcgccggctggatgacaggcg																										TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:3964890delA	uc002lzc.1	-	2	255	c.162delT	c.(160-162)CGTfs	p.R54fs	DAPK3_uc002lzd.1_Frame_Shift_Del_p.R54fs	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	54	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTCACCCCACGCCGGCTGG	0.632													---	---	---								-	3964890	-	-	3964890	7	5	203	1	0	1	0	1	0	0	0	0	4254	146	6	0	1230	0	DAPK3	19	3964890	Frame_Shift_Del	DEL	A	TCGA-CV-6945-01A-11D-1912-08		3964890	55164093	129	37245											
C19orf12	83636	broad.mit.edu	37	chr19	30193700	30193700	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagctgctgctgcagggcCtcgctgcccatgaccagcgc	6	6	13	16	2	0	1	0	1	0	0	1	1	0	1	3	1	7	6	3	1	0	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:30193700C>T	uc002nsk.2	-	3	776	c.345G>A	c.(343-345)GAG>GAA	p.E115E	C19orf12_uc002nsj.2_Silent_p.E126E|C19orf12_uc002nsl.2_3'UTR|C19orf12_uc002nsm.2_Intron	NM_031448	NP_113636	Q9NSK7	CS012_HUMAN	hypothetical protein LOC83636 isoform 2	115						integral to membrane					0	Ovarian(5;0.000567)|Breast(6;0.0203)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0435)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.183)			GCTGCAGGGCCTCGCTGCCCA	0.642													10	22					0	0	0	0	T	30193700	T	T	30193700	2	4	203	1	0	0	0	0	0	0	0	1	1918	680	24	4		4	C19orf12	19	30193700	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	26228810	30193700	28935283	130	37246											
ATP4A	495	broad.mit.edu	37	chr19	36046418	36046418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaccatctcggggtgggtgCgcagggcctcgaccagttcc	6	7	14	14	3	1	0	0	0	1	0	4	1	2	0	4	4	1	2	4	4	0	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:36046418C>T	uc002oal.1	-	14	2110	c.2081G>A	c.(2080-2082)CGC>CAC	p.R694H	ATP4A_uc010eee.1_5'UTR	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	694	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GGGGTGGGTGCGCAGGGCCTC	0.652													11	30					0	0	0	0	T	36046418	T	T	36046418	3	4	203	1	0	0	0	0	1	0	0	0	1147	768	27	1	1062	1	ATP4A	19	36046418	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	5852718	36046418	23082565	131	37247											
CATSPERG	57828	broad.mit.edu	37	chr19	38860883	38860883	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccactcagtcccaagcgggcCcttttcatcatcatggtgag	8	10	9	14	1	4	1	4	1	0	0	5	1	5	1	3	2	1	0	3	2	1	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:38860883C>A	uc002oih.3	+	28	3285	c.3198C>A	c.(3196-3198)GCC>GCA	p.A1066A	CATSPERG_uc002oig.3_Silent_p.A1026A|CATSPERG_uc002oif.3_Silent_p.A706A|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	1066	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						CCAAGCGGGCCCTTTTCATCA	0.597													13	18					4.3838e-07	1.04018e-06	1	0	A	38860883	A	A	38860883	2	1	203	1	0	0	0	0	0	0	0	1	2704	610	22	4		4	CATSPERG	19	38860883	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	2814465	38860883	20268100	132	37248											
LILRB1	10859	broad.mit.edu	37	chr19	55143396	55143396	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctctcctaggagcctacatCaaacccaccctctcagccca	10	8	4	19	0	3	0	2	0	2	0	6	1	4	1	5	1	4	0	5	1	3	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:55143396C>G	uc002qgj.2	+	6	709	c.369C>G	c.(367-369)ATC>ATG	p.I123M	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.I123M|LILRB1_uc002qgk.2_Missense_Mutation_p.I123M|LILRB1_uc002qgm.2_Missense_Mutation_p.I123M|LILRB1_uc010erq.2_Missense_Mutation_p.I123M|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	123	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GAGCCTACATCAAACCCACCC	0.582										HNSCC(37;0.09)			18	101					0	0	0	0	G	55143396	G	G	55143396	3	3	203	1	0	0	0	0	1	0	0	0	8831	816	29	2	383	2	LILRB1	19	55143396	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	16282513	55143396	3985587	133	37249											
NLRP2	55655	broad.mit.edu	37	chr19	55493571	55493571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atatattgaagacgaagttcCgggagatgtggaagagctgg	13	9	15	4	2	0	4	0	1	0	3	1	7	1	5	1	3	1	2	1	3	5	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:55493571C>T	uc002qij.2	+	6	591	c.505C>T	c.(505-507)CGG>TGG	p.R169W	NLRP2_uc010yfp.1_Missense_Mutation_p.R146W|NLRP2_uc010esn.2_Missense_Mutation_p.R145W|NLRP2_uc010eso.2_Missense_Mutation_p.R166W|NLRP2_uc010esp.2_Missense_Mutation_p.R147W	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	169					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GACGAAGTTCCGGGAGATGTG	0.483													96	162					0	0	0	0	T	55493571	T	T	55493571	3	4	203	1	0	0	0	0	1	0	0	0	10531	643	23	1	523	1	NLRP2	19	55493571	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	350175	55493571	3635412	134	37250											
NLRP4	147945	broad.mit.edu	37	chr19	56370340	56370340	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttccaactgtcccaagagatAaagcagcaaattcaccagtg	15	8	7	11	0	1	1	1	0	0	1	3	2	3	1	3	0	3	2	3	0	5	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:56370340A>G	uc002qmd.3	+	3	2003	c.1581A>G	c.(1579-1581)ATA>ATG	p.I527M	NLRP4_uc002qmf.2_Missense_Mutation_p.I452M|NLRP4_uc010etf.2_Missense_Mutation_p.I358M	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	527							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCCAAGAGATAAAGCAGCAAA	0.428													15	70					0	0	0	0	G	56370340	G	G	56370340	3	3	203	1	0	0	0	0	1	0	0	0	10533	352	13	5	1587	5	NLRP4	19	56370340	Missense_Mutation	SNP	A	TCGA-CV-6945-01A-11D-1912-08	876769	56370340	2758643	135	37251											
ZSCAN18	65982	broad.mit.edu	37	chr19	58596681	58596681	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgcctccgtaggcagctcagGcagcacccccgcgggggcgg	5	3	16	17	5	1	0	1	0	0	0	2	0	2	0	4	5	2	5	4	5	1	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:58596681G>A	uc002qri.2	-	7	1213	c.904C>T	c.(904-906)CCT>TCT	p.P302S	ZSCAN18_uc002qrj.3_Missense_Mutation_p.P301S|ZSCAN18_uc010yhs.1_Missense_Mutation_p.P166S|ZSCAN18_uc002qrh.2_Missense_Mutation_p.P302S|ZSCAN18_uc010yht.1_Missense_Mutation_p.P358S|ZSCAN18_uc002qrk.1_3'UTR|ZSCAN18_uc002qrl.2_3'UTR	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	302					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGCAGCTCAGGCAGCACCCCC	0.741													8	10					0	0	0	0	A	58596681	A	A	58596681	3	1	203	1	0	0	0	0	1	0	0	0	18297	1203	42	4	632	4	ZSCAN18	19	58596681	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	2226341	58596681	532302	136	37252											
MZF1	7593	broad.mit.edu	37	chr19	59073763	59073763	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagcccaggccgcactcaccGcagtggtagggcttttcgcc	7	7	12	15	3	1	0	1	0	0	0	2	0	1	0	4	3	1	4	4	3	2	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:59073763G>A	uc002qto.2	-	6	2442	c.1881C>T	c.(1879-1881)TGC>TGT	p.C627C	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Silent_p.C627C	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	627	C2H2-type 10.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		CGCACTCACCGCAGTGGTAGG	0.672													8	14					0	0	0	0	A	59073763	A	A	59073763	2	1	203	1	0	0	0	0	0	0	0	1	10161	1079	38	1		1	MZF1	19	59073763	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	477082	59073763	55220	137	37253											
MMP24	10893	broad.mit.edu	37	chr20	33855127	33855127	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccccctcggccgcccctcGgggaccggccatccacacca	5	3	11	22	4	0	0	0	0	0	0	3	1	1	1	9	5	0	0	9	5	0	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr20:33855127G>A	uc002xbu.2	+	6	1102	c.1099G>A	c.(1099-1101)GGG>AGG	p.G367R	EDEM2_uc010zuv.1_Intron	NM_006690	NP_006681	Q9Y5R2	MMP24_HUMAN	matrix metalloproteinase 24 preproprotein	367	Extracellular (Potential).				proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GCCGCCCCTCGGGGACCGGCC	0.637													4	12					0	0	0	0	A	33855127	A	A	33855127	3	1	203	1	0	0	0	0	1	0	0	0	9714	1116	39	1	871	1	MMP24	20	33855127	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08		33855127	29170393	138	37254											
RBM11	54033	broad.mit.edu	37	chr21	15599316	15599316	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgttccagatcttgaggctgGacccagctcatataaatgga	11	11	10	9	0	2	2	1	1	1	1	3	4	3	4	2	3	1	3	2	3	3	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:15599316G>C	uc002yjo.3	+	5	590	c.548G>C	c.(547-549)GGA>GCA	p.G183A	RBM11_uc002yjn.3_Missense_Mutation_p.G69A|RBM11_uc002yjp.3_Missense_Mutation_p.G69A	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	183							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CTTGAGGCTGGACCCAGCTCA	0.463													5	303					0	0	0	0	C	15599316	C	C	15599316	3	2	203	1	0	0	0	0	1	0	0	0	13177	1174	41	2	566	2	RBM11	21	15599316	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08		15599316	32530579	139	37255			1	55		5	5	284	G		1.685294e-13
RBM11	54033	broad.mit.edu	37	chr21	15599442	15599442	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgttccagatcttgaggctgGacccagctcatataaatgga	11	11	10	9	0	2	2	1	1	1	1	3	4	3	4	2	3	1	3	2	3	3	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:15599442G>C	uc002yjo.3	+	5	716	c.674G>C	c.(673-675)GGA>GCA	p.G225A	RBM11_uc002yjn.3_Missense_Mutation_p.G111A|RBM11_uc002yjp.3_Missense_Mutation_p.G111A	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	225							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CTTGAGGCTGGACCCAGCTCA	0.423													42	229					0	0	0	0	C	15599442	C	C	15599442	3	2	203	1	0	0	0	0	1	0	0	0	13177	1174	41	2	692	2	RBM11	21	15599442	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	126	15599442	32530453	140	37256			1	55		5	5	284	G		1.685294e-13
RBM11	54033	broad.mit.edu	37	chr21	15599531	15599531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagacaaaagcaaacaagtGatagtgatagtagcacagac	20	5	10	6	0	0	4	0	2	0	2	0	5	0	4	0	0	3	3	0	0	7	3			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:15599531G>A	uc002yjo.3	+	5	805	c.763G>A	c.(763-765)GAT>AAT	p.D255N	RBM11_uc002yjn.3_Missense_Mutation_p.D141N|RBM11_uc002yjp.3_Missense_Mutation_p.D141N	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	255							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		GCAAACAAGTGATAGTGATAG	0.388													22	130					0	0	0	0	A	15599531	A	A	15599531	3	1	203	1	0	0	0	0	1	0	0	0	13177	1290	45	2	781	2	RBM11	21	15599531	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	89	15599531	32530364	141	37257			1	55		5	5	284	G		1.685294e-13
RBM11	54033	broad.mit.edu	37	chr21	15599567	15599567	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacaacaacagaggcaacGaatgtagccaaaagttccga	18	4	9	10	2	0	2	0	0	0	2	1	4	1	2	2	1	4	3	2	1	7	2	rs61733445		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:15599567G>T	uc002yjo.3	+	5	841	c.799G>T	c.(799-801)GAA>TAA	p.E267*	RBM11_uc002yjn.3_Nonsense_Mutation_p.E153*|RBM11_uc002yjp.3_Nonsense_Mutation_p.E153*	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	267							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CAGAGGCAACGAATGTAGCCA	0.358													15	86					2.98522e-18	8.03404e-18	1	0	T	15599567	T	T	15599567	4	4	203	1	0	0	0	0	0	1	0	0	13177	1059	37	3	817	3	RBM11	21	15599567	Nonsense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	36	15599567	32530328	142	37258			1	55		5	5	284	G		1.685294e-13
RBM11	54033	broad.mit.edu	37	chr21	15599599	15599599	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagttccgaaagtctaagaaGaagaaaagatactagtatta	20	9	8	4	1	1	4	0	0	1	4	2	5	2	4	1	0	1	2	1	0	11	6			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:15599599G>A	uc002yjo.3	+	5	873	c.831G>A	c.(829-831)AAG>AAA	p.K277K	RBM11_uc002yjn.3_Silent_p.K163K|RBM11_uc002yjp.3_Silent_p.K163K	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	277							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		AGTCTAAGAAGAAGAAAAGAT	0.328													12	62					0	0	0	0	A	15599599	A	A	15599599	2	1	203	1	0	0	0	0	0	0	0	1	13177	933	33	2		2	RBM11	21	15599599	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	32	15599599	32530296	143	37259			1	55		5	5	284	G		1.685294e-13
KRTAP13-2	337959	broad.mit.edu	37	chr21	31744390	31744390	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctatagagagaggaacccaGctggcaggtgctgggagagc	11	5	16	9	0	0	3	0	0	0	3	0	6	0	4	2	4	4	3	2	4	3	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:31744390G>T	uc002ynz.3	-	1	168	c.142C>A	c.(142-144)CTG>ATG	p.L48M		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	48	1.|5 X 10 AA approximate repeats.					intermediate filament					0						GAGGAACCCAGCTGGCAGGTG	0.602													25	72					1.64293e-13	4.30599e-13	1	0	T	31744390	T	T	31744390	3	4	203	1	0	0	0	0	1	0	0	0	8562	962	34	4	389	4	KRTAP13-2	21	31744390	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	16144791	31744390	16385505	144	37260											
CELSR1	9620	broad.mit.edu	37	chr22	46860111	46860111	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccaccccctccacgaagaGggccagcagcggggacagga	10	1	15	15	2	0	1	0	0	0	1	1	4	1	3	5	5	2	1	5	5	1	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr22:46860111G>A	uc003bhw.1	-	2	3676	c.3676C>T	c.(3676-3678)CTC>TTC	p.L1226F		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1226	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCCACGAAGAGGGCCAGCAGC	0.602													12	39					0	0	0	0	A	46860111	A	A	46860111	3	1	203	1	0	0	0	0	1	0	0	0	3236	1000	35	4	5504	4	CELSR1	22	46860111	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08		46860111	4444455	145	37261											
ZBED4	9889	broad.mit.edu	37	chr22	50279257	50279257	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacaccaatgagaagttttaCgattctcacccagttgccaa	13	10	7	11	1	1	1	1	1	1	1	2	4	1	1	3	0	2	2	3	0	4	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr22:50279257C>T	uc003bix.2	+	2	2417	c.1947C>T	c.(1945-1947)TAC>TAT	p.Y649Y		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	649						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		AGAAGTTTTACGATTCTCACC	0.493													16	48					0	0	0	0	T	50279257	T	T	50279257	2	4	203	1	0	0	0	0	0	0	0	1	17587	547	19	1		1	ZBED4	22	50279257	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	3419146	50279257	1025309	146	37262											
SHANK3	85358	broad.mit.edu	37	chr22	51137137	51137137	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctcagcattggggagggCggtttctgggagggaaccgt	6	9	19	7	2	2	0	1	0	1	0	2	3	2	3	1	6	3	3	1	6	1	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr22:51137137C>T	uc003bne.1	+	13	1566	c.1566C>T	c.(1564-1566)GGC>GGT	p.G522G	SHANK3_uc003bnf.1_5'UTR	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	522										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		TTGGGGAGGGCGGTTTCTGGG	0.652													8	25					0	0	0	0	T	51137137	T	T	51137137	2	4	203	1	0	0	0	0	0	0	0	1	14331	755	27	1		1	SHANK3	22	51137137	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08	857880	51137137	167429	147	37263											
ASMTL	8623	broad.mit.edu	37	chrX	1538002	1538002	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctccgggctctggtagtaCgcatcctggaacacagcagg	8	8	13	12	2	2	0	0	0	2	0	4	1	3	1	2	4	3	5	2	4	3	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:1538002C>T	uc004cpx.1	-	10	1362	c.1251G>A	c.(1249-1251)GCG>GCA	p.A417A	ASMTL_uc011mhe.1_Silent_p.A341A|ASMTL_uc004cpy.1_Silent_p.A401A|ASMTL_uc011mhf.1_Silent_p.A359A	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	417	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTGGTAGTACGCATCCTGGA	0.667													7	40					0	0	0	0	T	1538002	T	T	1538002	2	4	203	1	0	0	0	0	0	0	0	1	1048	523	19	1		1	ASMTL	23	1538002	Silent	SNP	C	TCGA-CV-6945-01A-11D-1912-08		1538002	153732558	148	37264											
FAM47C	442444	broad.mit.edu	37	chrX	37027194	37027194	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtccagtctccacctggaGcctccagagactggagtgtc	7	9	12	13	0	1	1	0	0	1	1	5	4	3	3	5	2	1	0	5	2	0	0			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:37027194G>A	uc004ddl.1	+	1	725	c.711G>A	c.(709-711)GAG>GAA	p.E237E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	237										ovary(3)	3						TCCACCTGGAGCCTCCAGAGA	0.632													37	15					0	0	0	0	A	37027194	A	A	37027194	2	1	203	1	0	0	0	0	0	0	0	1	5603	962	34	4		4	FAM47C	23	37027194	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	35489192	37027194	118243366	149	37265											
NYX	60506	broad.mit.edu	37	chrX	41333914	41333915	+	Frame_Shift_Ins	INS	-	A	A																															tccagtccaggcccgtccccINSagaaccagcggccaccaccg																										TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:41333914_41333915insA	uc004dfh.2	+	2	1638_1639	c.1208_1209insA	c.(1207-1209)CCAfs	p.P403fs	NYX_uc011mku.1_Frame_Shift_Ins_p.P398fs	NM_022567	NP_072089	Q9GZU5	NYX_HUMAN	nyctalopin precursor	403					response to stimulus|visual perception	intracellular|proteinaceous extracellular matrix				lung(2)	2						GGCCCGTCCCCAGAACCAGCGG	0.698													---	---	---								A	41333915	A	A	41333914	7	5	203	1	0	1	1	0	0	0	0	0	10851	594	21	0	1214	0	NYX	23	41333914	Frame_Shift_Ins	INS	-	TCGA-CV-6945-01A-11D-1912-08	4306720	41333914	113936646	150	37266											
DUSP21	63904	broad.mit.edu	37	chrX	44703891	44703891	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgtgcgcatgatcaactcGccggtaggtaacatccctga	10	8	10	13	4	1	2	1	2	0	0	3	2	2	2	3	2	3	3	3	2	3	2			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:44703891G>C	uc004dgd.2	+	1	643	c.513G>C	c.(511-513)TCG>TCC	p.S171S		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	171						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						TGATCAACTCGCCGGTAGGTA	0.512													13	35					0	0	0	0	C	44703891	C	C	44703891	2	2	203	1	0	0	0	0	0	0	0	1	4842	1074	38	3		3	DUSP21	23	44703891	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	3369977	44703891	110566669	151	37267											
ZXDA	7789	broad.mit.edu	37	chrX	57935809	57935809	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcatggcccttcatgtgcGccttgaggttgtacacggtg	5	12	13	11	2	2	1	2	1	0	0	2	1	2	1	2	3	2	3	2	3	1	4			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:57935809G>A	uc004dve.2	-	1	1259	c.1046C>T	c.(1045-1047)GCG>GTG	p.A349V		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	349	C2H2-type 3.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CTTCATGTGCGCCTTGAGGTT	0.617													16	23					0	0	0	0	A	57935809	A	A	57935809	3	1	203	1	0	0	0	0	1	0	0	0	18317	1087	38	1	1357	1	ZXDA	23	57935809	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	13231918	57935809	97334751	152	37268											
AR	367	broad.mit.edu	37	chrX	66765158	66765158	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcgccagtttgctgctgcTgcagcagcagcagcagcagc	7	6	14	14	2	0	0	0	0	0	0	0	0	0	0	1	1	10	10	1	1	0	1	rs78686797		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:66765158T>A	uc004dwu.1	+	1	1285	c.170T>A	c.(169-171)CTG>CAG	p.L57Q	AR_uc011mpd.1_Missense_Mutation_p.L57Q|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.L57Q	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	57	Poly-Leu.|Modulating.		L -> Q (in prostate cancer).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TTGCTGCTGCTgcagcagcag	0.338									Androgen_Insensitivity_Syndrome				5	19					0	0	0	0	A	66765158	A	A	66765158	3	1	203	1	0	0	0	0	1	0	0	0	836	1580	55	5	172	5	AR	23	66765158	Missense_Mutation	SNP	T	TCGA-CV-6945-01A-11D-1912-08	8829349	66765158	88505402	153	37269											
KIAA2022	340533	broad.mit.edu	37	chrX	73962796	73962796	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ataacagggggctccttacgGgttacttttcttctcttttt	6	18	8	9	1	2	0	0	0	2	0	4	0	3	0	1	3	3	2	1	3	3	8			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:73962796G>C	uc004eby.2	-	3	2213	c.1596C>G	c.(1594-1596)ACC>ACG	p.T532T		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	532					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GCTCCTTACGGGTTACTTTTC	0.418													17	9					0	0	0	0	C	73962796	C	C	73962796	2	2	203	1	0	0	0	0	0	0	0	1	8308	1219	43	4		4	KIAA2022	23	73962796	Silent	SNP	G	TCGA-CV-6945-01A-11D-1912-08	7197638	73962796	81307764	154	37270											
MAGT1	84061	broad.mit.edu	37	chrX	77112989	77112989	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaagttggagctgaattcatGtttagctgaataaaaacgag	16	11	10	4	1	1	2	1	2	0	0	1	4	1	3	0	1	3	4	0	1	7	5			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:77112989G>T	uc004fof.2	-	4	554	c.492C>A	c.(490-492)AAC>AAA	p.N164K	MAGT1_uc004fog.3_RNA	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	132					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						CTGAATTCATGTTTAGCTGAA	0.338													10	82					0.00185496	0.00402075	1	0	T	77112989	T	T	77112989	3	4	203	1	0	0	0	0	1	0	0	0	9249	1368	48	4	639	4	MAGT1	23	77112989	Missense_Mutation	SNP	G	TCGA-CV-6945-01A-11D-1912-08	3150193	77112989	78157571	155	37271											
BEX5	340542	broad.mit.edu	37	chrX	101408934	101408934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaaaactcatcatgatgatCatggtgaggagggtccccta	12	9	11	9	0	3	3	3	3	0	0	4	4	4	4	2	3	1	1	2	3	3	1			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:101408934C>T	uc010nnz.2	-	3	606	c.304G>A	c.(304-306)GAT>AAT	p.D102N	BEX5_uc004eir.2_Missense_Mutation_p.D102N	NM_001159560	NP_001153032	Q5H9J7	BEX5_HUMAN	brain expressed, X-linked 5	102						cytoplasm				upper_aerodigestive_tract(1)	1						TCATGATGATCATGGTGAGGA	0.418													36	25					0	0	0	0	T	101408934	T	T	101408934	3	4	203	1	0	0	0	0	1	0	0	0	1416	826	29	2	35	2	BEX5	23	101408934	Missense_Mutation	SNP	C	TCGA-CV-6945-01A-11D-1912-08	24295945	101408934	53861626	156	37272											
CAMTA1	23261	broad.mit.edu	37	chr1	7798213	7798213	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttctaagcagtctgtccccGagacactcagccccagtgaa	10	8	9	14	1	3	2	1	1	2	1	4	3	4	2	4	0	2	2	4	0	2	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:7798213G>A	uc001aoi.2	+	16	4060	c.3853G>A	c.(3853-3855)GAG>AAG	p.E1285K	CAMTA1_uc010nzv.1_Missense_Mutation_p.E372K|CAMTA1_uc001aok.3_Missense_Mutation_p.E328K|CAMTA1_uc001aoj.2_Missense_Mutation_p.E241K	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GTCTGTCCCCGAGACACTCAG	0.552													23	14					0	0	0	0	A	7798213	A	A	7798213	3	1	204	1	0	0	0	0	1	0	0	0	2625	1059	37	1	3915	1	CAMTA1	1	7798213	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08		7798213	241452408	1	37273											
AHDC1	27245	broad.mit.edu	37	chr1	27875791	27875792	+	Frame_Shift_Ins	INS	-	G	G																															gagggcgggggcaccagcttINSggggaaggtctcggctgccc																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:27875791_27875792insG	uc009vsy.2	-	6	3804_3805	c.2835_2836insC	c.(2833-2838)CCCAAGfs	p.P945fs	AHDC1_uc009vsz.1_Frame_Shift_Ins_p.P945fs	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	945_946							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GGCACCAGCTTGGGGAAGGTCT	0.678													---	---	---								G	27875792	G	G	27875791	7	5	204	1	0	1	1	0	0	0	0	0	412	1821	63	0	1979	0	AHDC1	1	27875791	Frame_Shift_Ins	INS	-	TCGA-CV-6948-01A-11D-1912-08	20077578	27875791	221374830	2	37274											
MACF1	23499	broad.mit.edu	37	chr1	39951383	39951383	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaaggcaactccaggagaGggctaaacaaaccttccaaa	16	4	9	12	0	0	1	0	0	0	1	2	2	2	1	4	3	3	2	4	3	6	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:39951383G>A	uc010oiu.1	+	64	17865	c.17734G>A	c.(17734-17736)GGG>AGG	p.G5912R	MACF1_uc010ois.1_Missense_Mutation_p.G5404R|MACF1_uc001cde.1_Missense_Mutation_p.G318R|MACF1_uc001cdf.1_Missense_Mutation_p.G287R|MACF1_uc001cdg.2_3'UTR|MACF1_uc001cdh.2_3'UTR	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	7362	C-terminal tail (By similarity).				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTCCAGGAGAGGGCTAAACAA	0.542													6	129					0	0	0	0	A	39951383	A	A	39951383	3	1	204	1	0	0	0	0	1	0	0	0	9195	1000	35	4	22757	4	MACF1	1	39951383	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	12075592	39951383	209299238	3	37275											
ZNF643	65243	broad.mit.edu	37	chr1	40929123	40929123	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctttaggcatgattcatcCtttgctaaacatcagagaat	12	13	7	9	0	2	2	2	1	0	1	3	3	3	2	2	1	2	2	2	1	4	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:40929123C>G	uc001cfn.1	+	5	1764	c.1467C>G	c.(1465-1467)TCC>TCG	p.S489S	ZNF643_uc001cfl.1_Silent_p.S387S|ZNF643_uc001cfm.1_Silent_p.S355S	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	489	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			ATGATTCATCCTTTGCTAAAC	0.388													4	47					0	0	0	0	G	40929123	G	G	40929123	2	3	204	1	0	0	0	0	0	0	0	1	18126	668	24	4		4	ZNF643	1	40929123	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	977740	40929123	208321498	4	37276											
ST3GAL3	6487	broad.mit.edu	37	chr1	44365306	44365306	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggcgccatgcagcggccTgagcagtacgagcgcgattc	8	5	16	12	5	0	1	0	1	0	0	1	4	0	1	2	2	5	3	2	2	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:44365306T>A	uc001ckc.2	+	9	828	c.651T>A	c.(649-651)CCT>CCA	p.P217P	ST3GAL3_uc010okj.1_RNA|ST3GAL3_uc001cjz.2_Silent_p.P232P|ST3GAL3_uc001cka.2_Intron|ST3GAL3_uc001ckb.2_Silent_p.P286P|ST3GAL3_uc001ckd.2_Silent_p.P271P|ST3GAL3_uc001cke.2_Silent_p.P201P|ST3GAL3_uc001ckf.2_Silent_p.P255P|ST3GAL3_uc001ckg.2_Silent_p.P217P|ST3GAL3_uc001ckh.2_Intron|ST3GAL3_uc001cki.2_Intron|ST3GAL3_uc009vwv.2_Silent_p.P217P|ST3GAL3_uc001ckj.2_RNA|ST3GAL3_uc009vww.2_Intron|ST3GAL3_uc001ckk.2_Silent_p.P186P|ST3GAL3_uc009vwy.2_Silent_p.P123P|ST3GAL3_uc009vwx.2_RNA|ST3GAL3_uc001ckm.2_Intron|ST3GAL3_uc001ckl.2_Intron|ST3GAL3_uc009vwz.2_Intron|ST3GAL3_uc001ckn.2_Intron|ST3GAL3_uc001ckp.2_Intron|ST3GAL3_uc001cko.2_Silent_p.P201P|ST3GAL3_uc009vxa.2_Silent_p.P4P|ST3GAL3_uc001ckq.2_Intron|ST3GAL3_uc001ckr.2_Silent_p.P170P|ST3GAL3_uc009vxb.2_Intron	NM_006279	NP_006270	Q11203	SIAT6_HUMAN	sialyltransferase 6 isoform j	217	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			ovary(3)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				TGCAGCGGCCTGAGCAGTACG	0.537													42	54					0	0	0	0	A	44365306	A	A	44365306	2	1	204	1	0	0	0	0	0	0	0	1	15282	1567	55	5		5	ST3GAL3	1	44365306	Silent	SNP	T	TCGA-CV-6948-01A-11D-1912-08	3436183	44365306	204885315	5	37277											
SLC6A9	6536	broad.mit.edu	37	chr1	44467092	44467094	+	In_Frame_Del	DEL	GAA	-	-																															agccccagcaggataagcatGaagaagaagagcagagacca																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:44467092_44467094delGAA	uc001cll.2	-	9	1579_1581	c.1387_1389delTTC	c.(1387-1389)TTCdel	p.F463del	SLC6A9_uc009vxe.2_In_Frame_Del_p.F319del|SLC6A9_uc010okm.1_In_Frame_Del_p.F390del|SLC6A9_uc001clm.2_In_Frame_Del_p.F409del|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_In_Frame_Del_p.F394del|SLC6A9_uc001cln.2_In_Frame_Del_p.F390del|SLC6A9_uc010oko.1_In_Frame_Del_p.F279del|SLC6A9_uc010okp.1_RNA	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	463	Helical; Name=8; (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GGATAAGCATGAAGAAGAAGAGC	0.64													---	---	---								-	44467094	-	-	44467092	7	5	204	1	0	1	0	1	0	0	0	0	14755	1281	45	0	755	0	SLC6A9	1	44467092	In_Frame_Del	DEL	GAA	TCGA-CV-6948-01A-11D-1912-08	101786	44467092	204783529	6	37278											
CC2D1B	200014	broad.mit.edu	37	chr1	52823543	52823543	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggccgtgcaggtttcttggCcactggggcctgtgctgggg	2	10	19	10	1	1	0	0	0	1	0	1	0	1	0	3	7	2	3	3	7	0	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:52823543C>G	uc001ctq.1	-	14	1645	c.1507G>C	c.(1507-1509)GCC>CCC	p.A503P	CC2D1B_uc001ctr.2_Missense_Mutation_p.A43P|CC2D1B_uc001cts.2_Missense_Mutation_p.A188P	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	503										ovary(2)	2						GGTTTCTTGGCCACTGGGGCC	0.602													30	11					0	0	0	0	G	52823543	G	G	52823543	3	3	204	1	0	0	0	0	1	0	0	0	2739	739	26	4	1113	4	CC2D1B	1	52823543	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	8356451	52823543	196427078	7	37279											
CLCA1	1179	broad.mit.edu	37	chr1	86961316	86961316	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagacggagagtgatacccCagcagagtggagcactgtac	12	5	13	11	1	0	4	0	1	0	3	0	6	0	5	3	2	4	3	3	2	2	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:86961316C>T	uc001dlt.2	+	12	2200	c.2071C>T	c.(2071-2073)CAG>TAG	p.Q691*		NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	691					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		AGTGATACCCCAGCAGAGTGG	0.448													21	7					0	0	0	0	T	86961316	T	T	86961316	4	4	204	1	0	0	0	0	0	1	0	0	3472	595	21	4	2117	4	CLCA1	1	86961316	Nonsense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	34137773	86961316	162289305	8	37280											
NBPF15	284565	broad.mit.edu	37	chr1	148594407	148594407	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttttccaggctctacggcGtgctgatggaagtggaagag	8	10	14	9	2	1	2	0	1	1	1	2	4	2	4	2	4	2	2	2	4	3	3	rs144416833	byFrequency	TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:148594407G>A	uc001esc.2	+	19	2269	c.1780G>A	c.(1780-1782)GTG>ATG	p.V594M		NM_173638	NP_775909	Q8N660	NBPFF_HUMAN	hypothetical protein LOC284565	594	NBPF 6.					cytoplasm					0	all_hematologic(923;0.032)					GCTCTACGGCGTGCTGATGGA	0.458													124	192					0	0	0	0	A	148594407	A	A	148594407	3	1	204	1	0	0	0	0	1	0	0	0	10249	1145	40	1	1838	1	NBPF15	1	148594407	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	61633091	148594407	100656214	9	37281											
SNX27	81609	broad.mit.edu	37	chr1	151640992	151640992	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctcacaaactctacattCagaattatacatcagctgtg	13	13	4	11	0	4	1	3	0	1	1	5	1	5	1	1	0	4	1	1	0	5	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:151640992C>T	uc001eyn.1	+	7	1046	c.1030C>T	c.(1030-1032)CAG>TAG	p.Q344*	SNX27_uc001eyo.2_Nonsense_Mutation_p.Q251*|SNX27_uc001eyp.2_Nonsense_Mutation_p.Q158*	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	344	Ras-associating.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACTCTACATTCAGAATTATAC	0.383													30	92					0	0	0	0	T	151640992	T	T	151640992	4	4	204	1	0	0	0	0	0	1	0	0	14961	827	29	2	1056	2	SNX27	1	151640992	Nonsense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	3046585	151640992	97609629	10	37282											
FLG	2312	broad.mit.edu	37	chr1	152276850	152276850	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggaagcttcatggtgatgCgaccatgagtgcctggagcc	8	9	15	9	1	1	2	1	2	0	0	1	5	1	4	3	3	4	1	3	3	1	1	rs139345866		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:152276850C>T	uc001ezu.1	-	3	10548	c.10512G>A	c.(10510-10512)TCG>TCA	p.S3504S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3504	Ser-rich.|Filaggrin 21.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGTGATGCGACCATGAGT	0.577									Ichthyosis				138	227					0	0	0	0	T	152276850	T	T	152276850	2	4	204	1	0	0	0	0	0	0	0	1	5954	755	27	1		1	FLG	1	152276850	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	635858	152276850	96973771	11	37283											
LMNA	4000	broad.mit.edu	37	chr1	156106747	156106747	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattggcagatcaagcgccaGaatggagatgatcccttgct	12	9	11	9	1	1	4	1	1	0	3	2	5	2	4	2	2	2	2	2	2	3	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:156106747G>A	uc001fni.2	+	8	1665	c.1416G>A	c.(1414-1416)CAG>CAA	p.Q472Q	LMNA_uc001fnf.1_Silent_p.Q472Q|LMNA_uc001fng.2_Silent_p.Q472Q|LMNA_uc001fnh.2_Silent_p.Q472Q|LMNA_uc009wro.1_Silent_p.Q472Q|LMNA_uc010pgz.1_Silent_p.Q360Q|LMNA_uc001fnj.2_Silent_p.Q391Q|LMNA_uc001fnk.2_Silent_p.Q373Q|LMNA_uc009wrp.2_3'UTR|LMNA_uc010pha.1_Silent_p.Q128Q	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	472	Tail.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)					TCAAGCGCCAGAATGGAGATG	0.592									Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome				23	19					0	0	0	0	A	156106747	A	A	156106747	2	1	204	1	0	0	0	0	0	0	0	1	8890	933	33	2		2	LMNA	1	156106747	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	3829897	156106747	93143874	12	37284											
KIAA1614	57710	broad.mit.edu	37	chr1	180910242	180910242	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcccctttggaccagaacAagaaaaggagcagcagcata	15	5	10	11	0	0	2	0	0	0	2	0	4	0	4	3	2	5	3	3	2	5	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:180910242A>G	uc001gok.2	+	7	3047	c.2980A>G	c.(2980-2982)AAG>GAG	p.K994E	KIAA1614_uc001gol.1_Missense_Mutation_p.K615E|KIAA1614_uc001gom.1_Missense_Mutation_p.K85E	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	994	Ser-rich.									ovary(3)|skin(1)	4						GGACCAGAACAAGAAAAGGAG	0.642													6	47					0	0	0	0	G	180910242	G	G	180910242	3	3	204	1	0	0	0	0	1	0	0	0	8287	131	5	5	3006	5	KIAA1614	1	180910242	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	24803495	180910242	68340379	13	37285											
TPR	7175	broad.mit.edu	37	chr1	186321170	186321170	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgttcagctaacaaagactCtctttgctgagaaagacgaa	14	11	8	8	1	2	3	1	1	1	3	3	5	2	3	0	0	3	3	0	0	4	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:186321170C>G	uc001grv.2	-	19	2704	c.2407G>C	c.(2407-2409)GAG>CAG	p.E803Q		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	803	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		AACAAAGACTCTCTTTGCTGA	0.318			T	NTRK1	papillary thyroid								19	100					0	0	0	0	G	186321170	G	G	186321170	3	3	204	1	0	0	0	0	1	0	0	0	16483	922	32	2	4816	2	TPR	1	186321170	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	5410928	186321170	62929451	14	37286											
CR1	1378	broad.mit.edu	37	chr1	207751469	207751469	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtttaggtgtcagcctggCtttgtcatgaaaggaccccg	8	11	13	9	1	2	1	2	1	0	0	2	3	2	2	3	3	1	2	3	3	2	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:207751469C>A	uc001hfy.2	+	21	3647	c.3507C>A	c.(3505-3507)GGC>GGA	p.G1169G	CR1_uc009xcl.1_Silent_p.G719G|CR1_uc001hfx.2_Silent_p.G1619G	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1169	Extracellular (Potential).|Sushi 18.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						GTCAGCCTGGCTTTGTCATGA	0.483													8	115					0.00010058	0.000121835	1	0	A	207751469	A	A	207751469	2	1	204	1	0	0	0	0	0	0	0	1	3855	784	28	4		4	CR1	1	207751469	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	21430299	207751469	41499152	15	37287											
LAMB3	3914	broad.mit.edu	37	chr1	209796421	209796421	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaccggccctgggaaggAcacccctgcagcgggagcca	8	2	13	18	2	0	0	0	0	0	0	0	3	0	3	7	4	3	1	7	4	1	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:209796421A>C	uc001hhg.2	-	16	2852	c.2462T>G	c.(2461-2463)GTC>GGC	p.V821G	LAMB3_uc009xco.2_Missense_Mutation_p.V821G|LAMB3_uc001hhh.2_Missense_Mutation_p.V821G|LAMB3_uc010psl.1_RNA	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	821	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CCTGGGAAGGACACCCCTGCA	0.632													44	60					0	0	0	0	C	209796421	C	C	209796421	3	2	204	1	0	0	0	0	1	0	0	0	8652	275	10	5	1084	5	LAMB3	1	209796421	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	2044952	209796421	39454200	16	37288											
PTPN14	5784	broad.mit.edu	37	chr1	214542900	214542900	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagacaaaaggtgcttgacCttcaagcccgtggttgcata	11	9	10	11	1	1	2	1	1	0	1	1	2	1	2	3	2	3	3	3	2	4	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:214542900C>T	uc001hkk.1	-	17	3442	c.3171G>A	c.(3169-3171)AAG>AAA	p.K1057K		NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	1057	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GGTGCTTGACCTTCAAGCCCG	0.478													94	204					0	0	0	0	T	214542900	T	T	214542900	2	4	204	1	0	0	0	0	0	0	0	1	12846	680	24	4		4	PTPN14	1	214542900	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	4746479	214542900	34707721	17	37289											
LEFTY2	7044	broad.mit.edu	37	chr1	226125198	226125198	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggcacagctgcacttctgCaccctcatgttgggcaggct	7	9	12	13	0	2	0	1	0	1	0	2	1	2	0	1	3	3	7	1	3	0	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:226125198C>A	uc001hpt.1	-	4	1124	c.1044G>T	c.(1042-1044)GTG>GTT	p.V348V	LEFTY2_uc010pvk.1_Silent_p.V314V|LEFTY2_uc009xek.1_3'UTR	NM_003240	NP_003231	O00292	LFTY2_HUMAN	endometrial bleeding associated factor	348					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					TGCACTTCTGCACCCTCATGT	0.617													35	59					3.11337e-16	4.12972e-16	1	0	A	226125198	A	A	226125198	2	1	204	1	0	0	0	0	0	0	0	1	8756	697	25	4		4	LEFTY2	1	226125198	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	11582298	226125198	23125423	18	37290											
LIN9	286826	broad.mit.edu	37	chr1	226454018	226454018	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcagcaattggcattgtctCatgaggttcattactctgag	9	13	11	8	0	3	2	2	2	2	0	4	2	3	2	0	3	2	4	0	3	2	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:226454018C>T	uc001hqa.2	-	9	1190	c.880G>A	c.(880-882)GAG>AAG	p.E294K	LIN9_uc001hqb.2_Missense_Mutation_p.E259K|LIN9_uc001hqc.2_Missense_Mutation_p.E226K|LIN9_uc009xel.1_Missense_Mutation_p.E259K	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	278	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		GGCATTGTCTCATGAGGTTCA	0.363													9	23					0	0	0	0	T	226454018	T	T	226454018	3	4	204	1	0	0	0	0	1	0	0	0	8855	835	29	2	824	2	LIN9	1	226454018	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	328820	226454018	22796603	19	37291											
CABC1	56997	broad.mit.edu	37	chr1	227170663	227170663	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacttcgaggagcggcccttCgccgccgcatccattgggca	6	8	12	15	5	0	0	0	0	0	0	3	2	1	1	4	3	2	2	4	3	1	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:227170663C>T	uc001hqm.1	+	13	4427	c.1008C>T	c.(1006-1008)TTC>TTT	p.F336F	CABC1_uc001hqn.1_Silent_p.F336F|CABC1_uc009xeq.1_Silent_p.F284F|CABC1_uc010pvq.1_Silent_p.F57F|CABC1_uc010pvr.1_Intron|CABC1_uc001hqo.1_Silent_p.F57F|CABC1_uc009xer.1_5'UTR	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	336	Protein kinase.				cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				AGCGGCCCTTCGCCGCCGCAT	0.642													3	5					0	0	0	0	T	227170663	T	T	227170663	2	4	204	1	0	0	0	0	0	0	0	1	2539	883	31	1		1	CABC1	1	227170663	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	716645	227170663	22079958	20	37292											
OR1C1	26188	broad.mit.edu	37	chr1	247921171	247921171	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcaggagaggattgagatCacagaagaaatgatggatga	16	7	14	4	0	1	6	1	3	0	4	1	10	1	8	0	3	1	1	0	3	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:247921171C>G	uc010pza.1	-	1	538	c.538G>C	c.(538-540)GAT>CAT	p.D180H		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGATTGAGATCACAGAAGAAA	0.483													17	29					0	0	0	0	G	247921171	G	G	247921171	3	3	204	1	0	0	0	0	1	0	0	0	11006	826	29	2	408	2	OR1C1	1	247921171	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	20750508	247921171	1329450	21	37293											
OR11L1	391189	broad.mit.edu	37	chr1	248005020	248005020	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagatgctggaggaacatgTacataggggagtgcagtcgc	12	7	16	6	1	0	1	0	0	0	1	1	5	0	4	0	4	4	3	0	4	3	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:248005020T>A	uc001idn.1	-	1	179	c.179A>T	c.(178-180)TAC>TTC	p.Y60F		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAGGAACATGTACATAGGGGA	0.547													12	21					0	0	0	0	A	248005020	A	A	248005020	3	1	204	1	0	0	0	0	1	0	0	0	10984	1638	57	5	793	5	OR11L1	1	248005020	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	83849	248005020	1245601	22	37294											
OR2T12	127064	broad.mit.edu	37	chr1	248458698	248458698	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatgagggaaagttggctCaggaggaagtacatgggcct	11	8	15	7	0	1	1	1	1	0	0	2	4	2	4	2	5	1	3	2	5	3	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr1:248458698C>T	uc010pzj.1	-	1	183	c.183G>A	c.(181-183)CTG>CTA	p.L61L		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			AAAGTTGGCTCAGGAGGAAGT	0.552													54	58					0	0	0	0	T	248458698	T	T	248458698	2	4	204	1	0	0	0	0	0	0	0	1	11073	813	29	2		2	OR2T12	1	248458698	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	453678	248458698	791923	23	37295											
KIF3C	3797	broad.mit.edu	37	chr2	26203809	26203809	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttcccccccagggagtcctgGagcagccgggtcagcttgga	6	7	14	14	1	1	0	1	0	0	0	3	3	3	3	5	4	3	2	5	4	0	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:26203809G>C	uc002rgu.2	-	1	1635	c.978C>G	c.(976-978)CTC>CTG	p.L326L	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Silent_p.L326L	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	326	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGAGTCCTGGAGCAGCCGGG	0.607													22	46					0	0	0	0	C	26203809	C	C	26203809	2	2	204	1	0	0	0	0	0	0	0	1	8341	1161	41	2		2	KIF3C	2	26203809	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08		26203809	216995564	24	37296											
PRKD3	23683	broad.mit.edu	37	chr2	37506980	37506980	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgggggtgatggctcttCtgtgtcatccaaaccccgac	6	12	11	12	1	4	1	1	1	3	0	5	2	5	1	3	3	1	1	3	3	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:37506980C>T	uc002rqd.2	-	7	1636	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K	PRKD3_uc002rqe.1_5'Flank|PRKD3_uc002rqf.1_Missense_Mutation_p.E361K	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	361					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				GATGGCTCTTCTGTGTCATCC	0.398													50	49					0	0	0	0	T	37506980	T	T	37506980	3	4	204	1	0	0	0	0	1	0	0	0	12582	922	32	2	1639	2	PRKD3	2	37506980	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	11303171	37506980	205692393	25	37297											
ABCG8	64241	broad.mit.edu	37	chr2	44099198	44099198	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtcactcgcagccctgtttCtagaaaaagtgcgtgactta	11	11	9	10	2	2	2	1	1	1	1	3	2	2	2	1	0	2	2	1	0	4	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:44099198C>T	uc002rtq.2	+	7	1138	c.1048C>T	c.(1048-1050)CTA>TTA	p.L350L	ABCG8_uc010yoa.1_Silent_p.L350L	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	350	Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGCCCTGTTTCTAGAAAAAGT	0.537													48	72					0	0	0	0	T	44099198	T	T	44099198	2	4	204	1	0	0	0	0	0	0	0	1	72	912	32	2		2	ABCG8	2	44099198	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	6592218	44099198	199100175	26	37298											
LRPPRC	10128	broad.mit.edu	37	chr2	44162018	44162018	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcagtagataggtcgcccCttagaaacaaaaaaattagc	17	7	9	8	1	0	2	0	0	0	2	1	3	0	2	2	1	3	2	2	1	8	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:44162018C>A	uc002rtr.2	-	24	2563	c.2505_splice	c.e24-1	p.K835_splice	LRPPRC_uc010yob.1_Splice_Site_p.K735_splice	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein						mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TAGGTCGCCCCTTAGAAACAA	0.328													23	38					2.21704e-12	2.84667e-12	1	0	A	44162018	A	A	44162018	5	1	204	1	0	0	0	0	0	0	1	0	9015	695	24	4	1740	4	LRPPRC	2	44162018	Splice_Site	SNP	C	TCGA-CV-6948-01A-11D-1912-08	62820	44162018	199037355	27	37299											
EFEMP1	2202	broad.mit.edu	37	chr2	56149558	56149558	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccagagtcagcatagttagGaaaagggctttcaacattgt	13	10	11	7	0	2	1	2	0	0	1	2	2	2	2	1	2	2	3	1	2	5	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:56149558G>A	uc002rzh.2	-	2	348	c.18C>T	c.(16-18)TTC>TTT	p.F6F	EFEMP1_uc002rzi.2_Silent_p.F6F|EFEMP1_uc002rzj.2_Silent_p.F6F|EFEMP1_uc010ypc.1_5'UTR	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	6					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCATAGTTAGGAAAAGGGCTT	0.428													66	71					0	0	0	0	A	56149558	A	A	56149558	2	1	204	1	0	0	0	0	0	0	0	1	4963	1165	41	2		2	EFEMP1	2	56149558	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	11987540	56149558	187049815	28	37300											
SLC5A7	60482	broad.mit.edu	37	chr2	108626706	108626706	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggcttcggacaaagaaatcGtttgggttatgcgaatcaca	13	10	11	7	3	1	1	1	0	0	1	3	3	1	2	0	3	1	3	0	3	4	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:108626706G>A	uc002tdv.2	+	9	1408	c.1132G>A	c.(1132-1134)GTT>ATT	p.V378I	SLC5A7_uc010ywm.1_Missense_Mutation_p.V131I|SLC5A7_uc010fjj.2_Missense_Mutation_p.V378I|SLC5A7_uc010ywn.1_Missense_Mutation_p.V265I	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	378	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity	p.V378I(1)		ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CAAAGAAATCGTTTGGGTTAT	0.443													42	60					0	0	0	0	A	108626706	A	A	108626706	3	1	204	1	0	0	0	0	1	0	0	0	14734	1145	40	1	1162	1	SLC5A7	2	108626706	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	52477148	108626706	134572667	29	37301											
LY75	4065	broad.mit.edu	37	chr2	160663608	160663608	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacttttattttcccatttGacaaatgtcacttctgatcc	9	19	3	10	0	2	2	1	2	1	0	4	2	4	2	2	0	1	0	2	0	3	7			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:160663608G>C	uc002ubc.3	-	34	4935	c.4866C>G	c.(4864-4866)GTC>GTG	p.V1622V	LY75_uc002ubb.3_Silent_p.V1622V|LY75_uc010fos.2_Intron	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1622	Extracellular (Potential).|C-type lectin 10.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TTTCCCATTTGACAAATGTCA	0.343													15	40					0	0	0	0	C	160663608	C	C	160663608	2	2	204	1	0	0	0	0	0	0	0	1	9150	1277	45	2		2	LY75	2	160663608	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	52036902	160663608	82535765	30	37302											
ITGB6	3694	broad.mit.edu	37	chr2	160994637	160994637	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaagagggtaccgttgttaCagatggctgtaaatgacaag	13	9	14	5	1	0	3	0	1	0	2	0	4	0	4	1	3	2	5	1	3	6	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:160994637C>T	uc002ubh.2	-	9	1197	c.1181G>A	c.(1180-1182)TGT>TAT	p.C394Y	ITGB6_uc010fou.2_Missense_Mutation_p.C394Y|ITGB6_uc010zcq.1_Missense_Mutation_p.C352Y|ITGB6_uc010fov.1_Missense_Mutation_p.C394Y	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	394	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						ACCGTTGTTACAGATGGCTGT	0.428													6	134					0	0	0	0	T	160994637	T	T	160994637	3	4	204	1	0	0	0	0	1	0	0	0	7938	478	17	4	1213	4	ITGB6	2	160994637	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	331029	160994637	82204736	31	37303											
KLHL23	151230	broad.mit.edu	37	chr2	170591601	170591601	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggattttctggatgcatTcagaacattttacttggatg	10	16	10	5	0	2	1	1	0	1	1	2	4	2	4	0	3	3	1	0	3	2	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:170591601T>C	uc002ufh.1	+	4	415	c.77T>C	c.(76-78)TTC>TCC	p.F26S	KLHL23_uc002ufi.1_Missense_Mutation_p.F26S	NM_144711	NP_653312	Q8NBE8	KLH23_HUMAN	kelch-like 23	26											0						CTGGATGCATTCAGAACATTT	0.363													5	118					0	0	0	0	C	170591601	C	C	170591601	3	2	204	1	0	0	0	0	1	0	0	0	8417	1783	62	5	79	5	KLHL23	2	170591601	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	9596964	170591601	72607772	32	37304											
ITGA4	3676	broad.mit.edu	37	chr2	182387035	182387035	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actctacatgtcaaactaccCgtgggtctttatttcattaa	11	15	5	10	1	4	0	2	0	2	0	4	0	4	0	1	1	3	0	1	1	5	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:182387035C>T	uc002unu.2	+	18	2803	c.2040C>T	c.(2038-2040)CCC>CCT	p.P680P	ITGA4_uc010frj.1_Silent_p.P162P|ITGA4_uc002unv.2_5'UTR	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	680	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TCAAACTACCCGTGGGTCTTT	0.338													25	47					0	0	0	0	T	182387035	T	T	182387035	2	4	204	1	0	0	0	0	0	0	0	1	7917	639	23	1		1	ITGA4	2	182387035	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	11795434	182387035	60812338	33	37305											
ZNF804A	91752	broad.mit.edu	37	chr2	185801843	185801843	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaataaaacaggacactctaGatgaaaaatacaacaaaata	25	6	4	6	0	1	2	0	1	1	1	1	3	1	3	0	1	3	0	0	1	11	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:185801843G>T	uc002uph.2	+	4	2314	c.1720G>T	c.(1720-1722)GAT>TAT	p.D574Y		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	574						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GGACACTCTAGATGAAAAATA	0.299													20	42					3.62473e-10	4.61722e-10	1	0	T	185801843	T	T	185801843	3	4	204	1	0	0	0	0	1	0	0	0	18237	942	33	2	1734	2	ZNF804A	2	185801843	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	3414808	185801843	57397530	34	37306											
RAB17	64284	broad.mit.edu	37	chr2	238483689	238483689	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgcagcatttggcctgcctCgcgggccccttgttcagagc	4	9	13	15	3	1	1	1	0	0	1	2	1	1	1	4	2	3	3	4	2	0	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:238483689C>T	uc002vwz.1	-	6	1256	c.612G>A	c.(610-612)GCG>GCA	p.A204A	RAB17_uc002vxa.1_RNA|RAB17_uc002vxb.1_RNA	NM_022449	NP_071894	Q9H0T7	RAB17_HUMAN	RAB17, member RAS oncogene family	204					protein transport|small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|protein binding				0		Renal(207;0.00272)|Breast(86;0.00297)|all_hematologic(139;0.182)|Ovarian(221;0.221)		Epithelial(121;9.36e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.26e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000354)|Lung(119;0.011)|LUSC - Lung squamous cell carcinoma(224;0.026)		TGGCCTGCCTCGCGGGCCCCT	0.642													30	39					0	0	0	0	T	238483689	T	T	238483689	2	4	204	1	0	0	0	0	0	0	0	1	12967	871	31	1		1	RAB17	2	238483689	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	52681846	238483689	4715684	35	37307											
FARP2	9855	broad.mit.edu	37	chr2	242380775	242380775	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccatcttcagcgaatgcCttttactcgctctctccctc	5	14	4	18	2	3	0	1	0	2	0	8	1	5	0	4	0	3	1	4	0	2	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr2:242380775C>G	uc002wbi.1	+	13	1332	c.1215C>G	c.(1213-1215)GCC>GCG	p.A405A	FARP2_uc010zoq.1_Silent_p.A405A|FARP2_uc010zor.1_Silent_p.A405A|uc002wbj.2_5'Flank	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	405					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		CAGCGAATGCCTTTTACTCGC	0.502													27	56					0	0	0	0	G	242380775	G	G	242380775	2	3	204	1	0	0	0	0	0	0	0	1	5709	668	24	4		4	FARP2	2	242380775	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	3897086	242380775	818598	36	37308											
EDEM1	9695	broad.mit.edu	37	chr3	5246816	5246816	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtggcctgggtgccgggctGgactccttctatgaatacct	6	11	13	11	1	1	1	0	1	1	0	2	2	2	2	4	4	2	1	4	4	3	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:5246816G>A	uc003bqi.2	+	6	1239	c.1107G>A	c.(1105-1107)CTG>CTA	p.L369L	EDEM1_uc011asz.1_Silent_p.L147L|EDEM1_uc003bqh.2_Silent_p.L369L	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	369	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		GTGCCGGGCTGGACTCCTTCT	0.453													62	29					0	0	0	0	A	5246816	A	A	5246816	2	1	204	1	0	0	0	0	0	0	0	1	4933	1335	47	4		4	EDEM1	3	5246816	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08		5246816	192775614	37	37309											
GRIP2	80852	broad.mit.edu	37	chr3	14565164	14565164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctccttgtagagggagaCgtccactgtctttgaaatga	9	11	11	10	1	1	4	0	2	1	2	3	5	3	4	3	1	0	1	3	1	2	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:14565164C>T	uc011avi.1	-	6	736	c.736G>A	c.(736-738)GTC>ATC	p.V246I	GRIP2_uc011avh.1_5'UTR|GRIP2_uc003byu.1_3'UTR|GRIP2_uc003byv.1_Missense_Mutation_p.V149I	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	149	PDZ 2.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						TAGAGGGAGACGTCCACTGTC	0.498													7	3					0	0	0	0	T	14565164	T	T	14565164	3	4	204	1	0	0	0	0	1	0	0	0	6827	536	19	1	2768	1	GRIP2	3	14565164	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	9318348	14565164	183457266	38	37310											
DALRD3	55152	broad.mit.edu	37	chr3	49053902	49053902	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcagcatctcaaacttgatgGtggccacagagagaacacca	14	7	9	11	0	2	3	2	1	1	2	3	4	2	3	2	2	3	1	2	2	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:49053902G>A	uc003cvk.1	-	8	1126	c.1106C>T	c.(1105-1107)ACC>ATC	p.T369I	DALRD3_uc003cvl.1_Missense_Mutation_p.T369I|DALRD3_uc003cvm.1_Missense_Mutation_p.T202I|DALRD3_uc010hko.1_Missense_Mutation_p.T202I|DALRD3_uc011bca.1_Missense_Mutation_p.T369I	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	369					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AAACTTGATGGTGGCCACAGA	0.577													22	8					0	0	0	0	A	49053902	A	A	49053902	3	1	204	1	0	0	0	0	1	0	0	0	4246	1261	44	4	545	4	DALRD3	3	49053902	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	34488738	49053902	148968528	39	37311											
CCDC36	339834	broad.mit.edu	37	chr3	49278823	49278823	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcaaaagacaaatgtgacagGtatgtaaacctttcaaatgg	17	9	9	6	0	1	2	1	1	0	1	1	2	1	2	1	2	1	3	1	2	7	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:49278823G>T	uc003cwk.2	+	6	782	c.395_splice	c.e6+1	p.S132_splice	CCDC36_uc003cwl.3_Splice_Site_p.S132_splice|CCDC36_uc011bck.1_Splice_Site_p.S132_splice	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36											ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		AATGTGACAGGTATGTAAACC	0.343													13	6					1.05317e-09	1.33098e-09	1	0	T	49278823	T	T	49278823	5	4	204	1	0	0	0	0	0	0	1	0	2821	1275	44	4	406	4	CCDC36	3	49278823	Splice_Site	SNP	G	TCGA-CV-6948-01A-11D-1912-08	224921	49278823	148743607	40	37312											
KIAA2018	205717	broad.mit.edu	37	chr3	113375182	113375182	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgacggtcaattggtggggGgccagtgttttgactaattc	7	14	14	6	1	1	2	1	2	0	0	2	2	1	2	1	5	0	1	1	5	2	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:113375182G>A	uc003eam.2	-	7	5758	c.5347C>T	c.(5347-5349)CCC>TCC	p.P1783S	KIAA2018_uc003eal.2_Missense_Mutation_p.P1727S	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1783					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						ATTGGTGGGGGGCCAGTGTTT	0.418													99	260					0	0	0	0	A	113375182	A	A	113375182	3	1	204	1	0	0	0	0	1	0	0	0	8307	1232	43	4	1394	4	KIAA2018	3	113375182	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	64096359	113375182	84647248	41	37313											
PIK3R4	30849	broad.mit.edu	37	chr3	130425836	130425836	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acaaatgccagcagaggactCggaacgaggaggtttcccag	13	5	13	10	2	0	1	0	0	0	1	2	5	1	4	2	4	3	2	2	4	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:130425836C>G	uc003enj.2	-	11	3258	c.2677G>C	c.(2677-2679)GAG>CAG	p.E893Q		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	893					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						GCAGAGGACTCGGAACGAGGA	0.502													3	53					0	0	0	0	G	130425836	G	G	130425836	3	3	204	1	0	0	0	0	1	0	0	0	11976	893	31	3	1439	3	PIK3R4	3	130425836	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	17050654	130425836	67596594	42	37314											
PIK3CB	5291	broad.mit.edu	37	chr3	138400825	138400825	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaccgaagatccaaaccagCttctttccagagtaaatcca	14	9	5	13	1	2	2	1	0	1	2	5	3	5	2	5	0	2	2	5	0	4	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:138400825C>T	uc011bmq.1	-	17	2488	c.2488G>A	c.(2488-2490)GCT>ACT	p.A830T	PIK3CB_uc011bmn.1_Missense_Mutation_p.A342T|PIK3CB_uc011bmo.1_Missense_Mutation_p.A281T|PIK3CB_uc011bmp.1_Missense_Mutation_p.A417T	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	830	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						TCCAAACCAGCTTCTTTCCAG	0.363													17	37					0	0	0	0	T	138400825	T	T	138400825	3	4	204	1	0	0	0	0	1	0	0	0	11969	797	28	4	746	4	PIK3CB	3	138400825	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	7974989	138400825	59621605	43	37315											
MRPS22	56945	broad.mit.edu	37	chr3	139069822	139069822	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgctgtgtggttttagactAtgtatagccaggacaggcat	9	13	12	7	0	0	1	0	0	0	1	0	2	0	2	1	3	2	4	1	3	4	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:139069822A>G	uc003etb.2	+	5	660	c.652A>G	c.(652-654)ATG>GTG	p.M218V	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.M217V|MRPS22_uc003ete.2_Missense_Mutation_p.M177V	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	218						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						GTTTTAGACTATGTATAGCCA	0.468													29	86					0	0	0	0	G	139069822	G	G	139069822	3	3	204	1	0	0	0	0	1	0	0	0	9886	449	16	5	670	5	MRPS22	3	139069822	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	668997	139069822	58952608	44	37316											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			13	79					0	0	0	0	A	178936091	A	A	178936091	3	1	204	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	39866269	178936091	19086339	45	37317											
DVL3	1857	broad.mit.edu	37	chr3	183885748	183885748	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacggaccggagggaggccCgcaagtatgccagcaacctg	10	4	14	13	3	1	0	1	0	0	0	1	3	1	3	4	4	3	3	4	4	3	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:183885748C>T	uc003fms.2	+	13	1533	c.1393C>T	c.(1393-1395)CGC>TGC	p.R465C	DVL3_uc011bqw.1_Missense_Mutation_p.R448C|DVL3_uc003fmt.2_Missense_Mutation_p.R136C|DVL3_uc003fmu.2_Missense_Mutation_p.R297C	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	465	DEP.			R -> P (in Ref. 1; AAB47447).	canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			GAGGGAGGCCCGCAAGTATGC	0.577													41	117					0	0	0	0	T	183885748	T	T	183885748	3	4	204	1	0	0	0	0	1	0	0	0	4859	652	23	1	1443	1	DVL3	3	183885748	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	4949657	183885748	14136682	46	37318											
ABCF3	55324	broad.mit.edu	37	chr3	183907447	183907447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagcggctagatggttacCggggagactttgagaccttc	8	9	14	10	2	0	3	0	1	0	3	1	5	0	3	3	4	2	2	3	4	2	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:183907447C>T	uc003fmz.2	+	13	1349	c.1216C>T	c.(1216-1218)CGG>TGG	p.R406W	ABCF3_uc003fna.2_Missense_Mutation_p.R400W|ABCF3_uc003fnb.2_Missense_Mutation_p.R87W	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	406	ABC transporter 1.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGATGGTTACCGGGGAGACTT	0.572													20	41					0	0	0	0	T	183907447	T	T	183907447	3	4	204	1	0	0	0	0	1	0	0	0	67	643	23	1	1266	1	ABCF3	3	183907447	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	21699	183907447	14114983	47	37319											
ETV5	2119	broad.mit.edu	37	chr3	185797720	185797721	+	Frame_Shift_Ins	INS	-	G	G																															tccaggctctggaagcgaatINSggggggcgggggcggggccc																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr3:185797720_185797721insG	uc003fpz.2	-	7	782_783	c.535_536insC	c.(535-537)CATfs	p.H179fs	ETV5_uc003fpy.2_Frame_Shift_Ins_p.H221fs	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	179					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			TGGAAGCGAATGGGGGGCGGGG	0.614			T	TMPRSS2|SCL45A3	Prostate 								---	---	---								G	185797721	G	G	185797720	7	5	204	1	0	1	1	0	0	0	0	0	5306	1464	51	0	1024	0	ETV5	3	185797720	Frame_Shift_Ins	INS	-	TCGA-CV-6948-01A-11D-1912-08	1890273	185797720	12224710	48	37320											
PIGG	54872	broad.mit.edu	37	chr4	499519	499519	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gactgcaggcattgatgacgGggagccttcctggctttgtc	6	11	14	10	1	0	2	0	2	0	0	2	4	1	3	2	4	2	3	2	4	0	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:499519G>A	uc003gak.3	+	3	509	c.373G>A	c.(373-375)GGG>AGG	p.G125R	PIGG_uc003gaj.3_Missense_Mutation_p.G125R|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Intron|PIGG_uc003gal.3_Missense_Mutation_p.G36R|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Missense_Mutation_p.G3R|PIGG_uc003gam.2_Missense_Mutation_p.G36R|PIGG_uc003gan.2_Missense_Mutation_p.G36R	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	125	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						ATTGATGACGGGGAGCCTTCC	0.428													3	50					0	0	0	0	A	499519	A	A	499519	3	1	204	1	0	0	0	0	1	0	0	0	11943	1232	43	4	383	4	PIGG	4	499519	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08		499519	190654757	49	37321											
DCAF16	54876	broad.mit.edu	37	chr4	17805431	17805431	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaggccagagggggccattCaggaattggttccagtttgg	9	9	16	7	0	1	2	1	0	0	2	2	3	2	3	3	6	0	2	3	6	1	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:17805431C>T	uc003gpn.2	-	3	1395	c.334G>A	c.(334-336)GAA>AAA	p.E112K	DCAF16_uc003gpo.2_RNA	NM_017741	NP_060211	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	112						CUL4 RING ubiquitin ligase complex				ovary(1)	1						GGGGGCCATTCAGGAATTGGT	0.493													64	55					0	0	0	0	T	17805431	T	T	17805431	3	4	204	1	0	0	0	0	1	0	0	0	4285	835	29	2	320	2	DCAF16	4	17805431	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	17305912	17805431	173348845	50	37322											
TLR1	7096	broad.mit.edu	37	chr4	38798908	38798908	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcttttattgacctcatCttctggcagctctggaagaa	8	14	8	11	0	4	2	1	1	3	1	4	3	4	3	2	2	2	3	2	2	3	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:38798908C>A	uc003gtl.2	-	4	1819	c.1545G>T	c.(1543-1545)AAG>AAT	p.K515N		NM_003263	NP_003254	Q15399	TLR1_HUMAN	toll-like receptor 1 precursor	515	Extracellular (Potential).				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			lung(2)|skin(2)|prostate(1)	5						TTGACCTCATCTTCTGGCAGC	0.433													121	37					1.50762e-44	2.13192e-44	1	0	A	38798908	A	A	38798908	3	1	204	1	0	0	0	0	1	0	0	0	16015	912	32	2	819	2	TLR1	4	38798908	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	20993477	38798908	152355368	51	37323											
ATP8A1	10396	broad.mit.edu	37	chr4	42618055	42618055	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgtaaaattcctaccttgcGtttgtttcttgttcactgca	8	18	6	9	1	2	0	1	0	1	0	3	0	3	0	2	0	3	5	2	0	3	8			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:42618055G>A	uc003gwr.2	-	5	636	c.404C>T	c.(403-405)ACG>ATG	p.T135M	ATP8A1_uc003gws.2_Missense_Mutation_p.T135M|ATP8A1_uc011byz.1_Missense_Mutation_p.T135M	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	135	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	CCTACCTTGCGTTTGTTTCTT	0.284													23	10					0	0	0	0	A	42618055	A	A	42618055	3	1	204	1	0	0	0	0	1	0	0	0	1194	1145	40	1	3300	1	ATP8A1	4	42618055	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	3819147	42618055	148536221	52	37324											
GRSF1	2926	broad.mit.edu	37	chr4	71702029	71702029	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggtaagtagttttggaCtccttccaaaggaaatgaag	13	11	10	7	0	0	1	0	1	0	0	3	3	3	3	3	3	0	3	3	3	5	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:71702029C>T	uc010iia.1	-	2	443	c.360G>A	c.(358-360)GAG>GAA	p.E120E	GRSF1_uc011caz.1_Silent_p.E2E|GRSF1_uc003hfs.2_5'UTR	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	120					mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			TAGTTTTGGACTCCTTCCAAA	0.368													29	53					0	0	0	0	T	71702029	T	T	71702029	2	4	204	1	0	0	0	0	0	0	0	1	6848	564	20	4		4	GRSF1	4	71702029	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	29083974	71702029	119452247	53	37325											
PPEF2	5470	broad.mit.edu	37	chr4	76813090	76813090	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catctccaggcgggccacgtAgcgccggtaccatctctgga	7	7	12	15	4	2	0	0	0	2	0	4	1	2	1	4	4	2	2	4	4	2	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:76813090A>C	uc003hix.2	-	3	454	c.97T>G	c.(97-99)TAC>GAC	p.Y33D	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.Y33D	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	33	IQ.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CGGGCCACGTAGCGCCGGTAC	0.577													28	72					0	0	0	0	C	76813090	C	C	76813090	3	2	204	1	0	0	0	0	1	0	0	0	12363	420	15	5	2224	5	PPEF2	4	76813090	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	5111061	76813090	114341186	54	37326											
PDLIM5	10611	broad.mit.edu	37	chr4	95376534	95376534	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgcctctgacaatctctaGtgtaagtaaactttacaaat	14	13	5	9	0	2	1	0	1	2	0	3	1	2	1	1	0	3	2	1	0	7	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:95376534G>A	uc003hti.2	+	2	246	c.95G>A	c.(94-96)AGT>AAT	p.S32N	PDLIM5_uc003htf.2_Missense_Mutation_p.S32N|PDLIM5_uc003htg.2_Missense_Mutation_p.S32N|PDLIM5_uc011cdx.1_Missense_Mutation_p.S32N|PDLIM5_uc003hth.2_Missense_Mutation_p.S32N|PDLIM5_uc003htj.2_5'UTR|PDLIM5_uc003htk.2_Missense_Mutation_p.S32N|PDLIM5_uc011cdy.1_5'UTR	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	32	PDZ.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		ACAATCTCTAGTGTAAGTAAA	0.428													15	11					0	0	0	0	A	95376534	A	A	95376534	3	1	204	1	0	0	0	0	1	0	0	0	11737	1043	36	4	97	4	PDLIM5	4	95376534	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	18563444	95376534	95777742	55	37327											
FBXW7	55294	broad.mit.edu	37	chr4	153247289	153247289	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccatcatattgaacacagcGgactgctgcaacatgaccca	13	7	8	13	1	1	2	1	2	0	0	1	3	1	3	2	1	5	2	2	1	3	2	rs149680468		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:153247289G>C	uc003ims.2	-	10	1662	c.1513C>G	c.(1513-1515)CGC>GGC	p.R505G	FBXW7_uc011cii.1_Missense_Mutation_p.R505G|FBXW7_uc003imt.2_Missense_Mutation_p.R505G|FBXW7_uc011cih.1_Missense_Mutation_p.R329G|FBXW7_uc003imq.2_Missense_Mutation_p.R425G|FBXW7_uc003imr.2_Missense_Mutation_p.R387G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468			Mis|N|D|F		colorectal|endometrial|T-ALL								55	17					0	0	0	0	C	153247289	C	C	153247289	3	2	204	1	0	0	0	0	1	0	0	0	5801	1116	39	3	622	3	FBXW7	4	153247289	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	57870755	153247289	37906987	56	37328											
VEGFC	7424	broad.mit.edu	37	chr4	177605120	177605120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccaatatgaagggacacaaCgacacacttcttcactatat	15	10	5	11	1	2	1	1	1	1	0	3	3	3	2	1	1	1	0	1	1	6	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:177605120C>T	uc003ius.1	-	7	1650	c.1220G>A	c.(1219-1221)CGT>CAT	p.R407H		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	407					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		AGGGACACAACGACACACTTC	0.418													28	59					0	0	0	0	T	177605120	T	T	177605120	3	4	204	1	0	0	0	0	1	0	0	0	17220	536	19	1	46	1	VEGFC	4	177605120	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	24357831	177605120	13549156	57	37329											
CDKN2AIP	55602	broad.mit.edu	37	chr4	184366790	184366790	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgaactggttgccaaggtGaagaaaagagggatatcgag	15	7	15	4	1	0	4	0	2	0	2	1	7	0	5	1	3	2	1	1	3	6	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr4:184366790G>A	uc003ivp.1	+	2	537	c.375G>A	c.(373-375)GTG>GTA	p.V125V	CDKN2AIP_uc003ivq.1_Intron	NM_017632	NP_060102	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	125					negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding				0		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		TTGCCAAGGTGAAGAAAAGAG	0.363													17	8					0	0	0	0	A	184366790	A	A	184366790	2	1	204	1	0	0	0	0	0	0	0	1	3177	1277	45	2		2	CDKN2AIP	4	184366790	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	6761670	184366790	6787486	58	37330											
CCT5	22948	broad.mit.edu	37	chr5	10256236	10256236	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaccgaacccctgattcaGacagcaaaaaccacgctggg	14	4	9	14	2	1	2	1	1	0	1	1	4	1	2	4	1	3	2	4	1	3	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:10256236G>A	uc003jeq.2	+	4	672	c.501G>A	c.(499-501)CAG>CAA	p.Q167Q	CCT5_uc011cmq.1_Intron|CCT5_uc003jer.2_Silent_p.Q167Q|CCT5_uc010its.2_Silent_p.Q167Q|CCT5_uc011cmr.1_Silent_p.Q112Q|CCT5_uc011cms.1_Silent_p.Q129Q|CCT5_uc011cmt.1_Silent_p.Q74Q	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	167					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						CCCTGATTCAGACAGCAAAAA	0.468													22	26					0	0	0	0	A	10256236	A	A	10256236	2	1	204	1	0	0	0	0	0	0	0	1	2971	933	33	2		2	CCT5	5	10256236	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08		10256236	170659024	59	37331											
COL4A3BP	10087	broad.mit.edu	37	chr5	74801935	74801935	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgccacccatgaatgtagtTtgtccactgggagtgggaag	9	10	13	9	0	0	1	0	1	0	0	1	3	1	3	3	2	1	2	3	2	3	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:74801935T>C	uc011csu.1	-	2	525	c.103A>G	c.(103-105)AAC>GAC	p.N35D	COL4A3BP_uc003kds.2_Missense_Mutation_p.N35D|COL4A3BP_uc003kdt.2_Missense_Mutation_p.N163D|COL4A3BP_uc003kdu.2_Missense_Mutation_p.N35D	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	35	PH.				ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		TGAATGTAGTTTGTCCACTGG	0.378													26	4					0	0	0	0	C	74801935	C	C	74801935	3	2	204	1	0	0	0	0	1	0	0	0	3707	1841	64	5	1835	5	COL4A3BP	5	74801935	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	64545699	74801935	106113325	60	37332											
ZFYVE16	9765	broad.mit.edu	37	chr5	79770505	79770505	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctactttctaaaggaccaGgatttatctattttatcaac	12	17	4	8	0	4	0	1	0	3	0	4	2	4	2	1	2	2	0	1	2	7	9			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:79770505G>A	uc003kgr.3	+	18	4619	c.4317G>A	c.(4315-4317)CAG>CAA	p.Q1439Q	ZFYVE16_uc003kgq.3_Silent_p.Q1439Q|ZFYVE16_uc003kgs.3_Silent_p.Q1439Q|ZFYVE16_uc003kgt.3_Silent_p.Q527Q|ZFYVE16_uc003kgu.3_Silent_p.Q191Q	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	1439					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TAAAGGACCAGGATTTATCTA	0.333													29	17					0	0	0	0	A	79770505	A	A	79770505	2	1	204	1	0	0	0	0	0	0	0	1	17731	991	35	4		4	ZFYVE16	5	79770505	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	4968570	79770505	101144755	61	37333											
MEF2C	4208	broad.mit.edu	37	chr5	88018742	88018742	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgagtgctagtgcaagcTctgtaggaggaaaggaaacc	15	7	13	6	0	1	1	0	1	1	0	1	4	1	4	1	3	4	4	1	3	6	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:88018742T>C	uc003kjj.2	-	11	1774	c.1101A>G	c.(1099-1101)GGA>GGG	p.G367G	MEF2C_uc003kji.2_Silent_p.G359G|MEF2C_uc003kjk.2_Silent_p.G367G|MEF2C_uc003kjm.2_Silent_p.G357G|MEF2C_uc003kjl.2_Silent_p.G377G	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	367					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		TAGTGCAAGCTCTGTAGGAGG	0.463										HNSCC(66;0.2)			4	7					0	0	0	0	C	88018742	C	C	88018742	2	2	204	1	0	0	0	0	0	0	0	1	9510	1565	54	5		5	MEF2C	5	88018742	Silent	SNP	T	TCGA-CV-6948-01A-11D-1912-08	8248237	88018742	92896518	62	37334											
GPR98	84059	broad.mit.edu	37	chr5	89988434	89988434	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atttttaggttatccaagtgCaactaactgatgcctctggt	10	15	8	8	0	1	1	0	1	1	0	2	1	2	1	2	2	4	2	2	2	5	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:89988434C>A	uc003kju.2	+	32	7060	c.6964C>A	c.(6964-6966)CAA>AAA	p.Q2322K	GPR98_uc003kjt.2_Missense_Mutation_p.Q28K|GPR98_uc003kjv.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2322	Calx-beta 16.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TATCCAAGTGCAACTAACTGA	0.348													9	4					0.00829132	0.00974913	1	0	A	89988434	A	A	89988434	3	1	204	1	0	0	0	0	1	0	0	0	6760	711	25	4	7090	4	GPR98	5	89988434	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	1969692	89988434	90926826	63	37335											
APC	324	broad.mit.edu	37	chr5	112175991	112175991	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaggacctattagatgattCagatgatgatgatattgaaa	17	12	9	3	0	1	7	1	5	0	2	1	8	1	8	1	1	0	0	1	1	5	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:112175991C>G	uc010jby.2	+	16	5080	c.4700C>G	c.(4699-4701)TCA>TGA	p.S1567*	APC_uc011cvt.1_Nonsense_Mutation_p.S1549*|APC_uc003kpz.3_Nonsense_Mutation_p.S1567*|APC_uc003kpy.3_Nonsense_Mutation_p.S1567*|APC_uc010jbz.2_Nonsense_Mutation_p.S1284*|APC_uc010jca.2_Nonsense_Mutation_p.S867*	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1567	Ser-rich.|Asp/Glu-rich (acidic).				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TTAGATGATTCAGATGATGAT	0.358		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			32	16					0	0	0	0	G	112175991	G	G	112175991	4	3	204	1	0	0	0	0	0	1	0	0	763	838	29	2	4758	2	APC	5	112175991	Nonsense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	22187557	112175991	68739269	64	37336											
KIF3A	11127	broad.mit.edu	37	chr5	132052070	132052070	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagggtggaaagtgaaagaTtgatttttgtagcttccttt	11	15	11	4	0	0	3	0	2	0	1	1	4	1	4	1	2	1	2	1	2	4	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:132052070T>C	uc003kxo.2	-	7	975	c.821A>G	c.(820-822)AAT>AGT	p.N274S	KIF3A_uc003kxn.2_Missense_Mutation_p.N233S|KIF3A_uc011cxf.1_Missense_Mutation_p.N274S|KIF3A_uc003kxp.2_Missense_Mutation_p.N274S	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	274	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAGTGAAAGATTGATTTTTGT	0.398													3	80					0	0	0	0	C	132052070	C	C	132052070	3	2	204	1	0	0	0	0	1	0	0	0	8339	1493	52	5	1322	5	KIF3A	5	132052070	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	19876079	132052070	48863190	65	37337											
SLC23A1	9963	broad.mit.edu	37	chr5	138707837	138707837	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaaggtaattctttttactAtgcccatcccaatggggaaa	13	12	8	8	0	1	0	0	0	1	0	2	2	2	1	2	3	2	1	2	3	6	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:138707837A>G	uc003leh.2	-	14	1752	c.1655T>C	c.(1654-1656)ATA>ACA	p.I552T	SLC23A1_uc003leg.2_Missense_Mutation_p.I556T	NM_005847	NP_005838	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (nucleobase	552					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	TCTTTTTACTATGCCCATCCC	0.443													43	47					0	0	0	0	G	138707837	G	G	138707837	3	3	204	1	0	0	0	0	1	0	0	0	14526	449	16	5	145	5	SLC23A1	5	138707837	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	6655767	138707837	42207423	66	37338											
PCDHB11	56125	broad.mit.edu	37	chr5	140580820	140580820	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggtcaactactcgctactCccgccccaggacctgcacct	8	7	7	19	2	1	0	1	0	0	0	3	1	2	1	5	2	4	2	5	2	3	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:140580820C>A	uc003liy.2	+	1	1473	c.1473C>A	c.(1471-1473)CTC>CTA	p.L491L	PCDHB11_uc011daj.1_Silent_p.L126L	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	491	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCGCTACTCCCGCCCCAGG	0.642													85	117					1.32003e-40	1.85035e-40	1	0	A	140580820	A	A	140580820	2	1	204	1	0	0	0	0	0	0	0	1	11590	842	30	2		2	PCDHB11	5	140580820	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	1872983	140580820	40334440	67	37339											
PCDHGA7	56108	broad.mit.edu	37	chr5	140763371	140763371	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcttacaggagaaatatCaactttagaaggattagatt	15	12	8	6	1	1	3	1	0	0	3	2	5	1	4	0	2	2	1	0	2	7	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr5:140763371C>A	uc003lka.1	+	1	905	c.905C>A	c.(904-906)TCA>TAA	p.S302*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Nonsense_Mutation_p.S302*	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	302	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGAAATATCAACTTTAGAA	0.403													19	36					7.07596e-05	8.6694e-05	1	0	A	140763371	A	A	140763371	4	1	204	1	0	0	0	0	0	1	0	0	11613	838	29	2	907	2	PCDHGA7	5	140763371	Nonsense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	182551	140763371	40151889	68	37340											
RREB1	6239	broad.mit.edu	37	chr6	7211049	7211071	+	Frame_Shift_Del	DEL	CCATGAGAAGGACCCTAACAGTG	-	-																															cttttcagacatatgaagatCcatgagaaggaccctaacag																								rs145494137		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:7211049_7211071delCCATGAGAAGGACCCTAACAGTG	uc003mxc.2	+	7	828_850	c.438_460delCCATGAGAAGGACCCTAACAGTG	c.(436-462)ATCCATGAGAAGGACCCTAACAGTGCCfs	p.I146fs	RREB1_uc010jnw.2_Frame_Shift_Del_p.I146fs|RREB1_uc003mxb.2_Frame_Shift_Del_p.I146fs|RREB1_uc010jnx.2_Frame_Shift_Del_p.I146fs|RREB1_uc003mxd.2_Frame_Shift_Del_p.I146fs	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	146_154					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				ATATGAAGATCCATGAGAAGGACCCTAACAGTGCCACAGCCAC	0.439													---	---	---								-	7211071	-	-	7211049	7	5	204	1	0	1	0	1	0	0	0	0	13744	845	30	0	452	0	RREB1	6	7211049	Frame_Shift_Del	DEL	CCATGAGAAGGACCCTAACAGTG	TCGA-CV-6948-01A-11D-1912-08		7211049	163904018	69	37341											
FAM8A1	51439	broad.mit.edu	37	chr6	17600920	17600920	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcaggagcaggcgggctgcGaggcgcccgaagccgcggcg	6	2	20	13	7	0	0	0	0	0	0	0	3	0	1	2	5	4	3	2	5	1	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:17600920G>A	uc003ncc.2	+	1	403	c.280G>A	c.(280-282)GAG>AAG	p.E94K		NM_016255	NP_057339	Q9UBU6	FA8A1_HUMAN	family with sequence similarity 8, member A1	94						integral to membrane					0	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.143)	all cancers(50;0.176)|Epithelial(50;0.204)			GGCGGGCTGCGAGGCGCCCGA	0.731													18	11					0	0	0	0	A	17600920	A	A	17600920	3	1	204	1	0	0	0	0	1	0	0	0	5681	1059	37	1	282	1	FAM8A1	6	17600920	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	10389871	17600920	153514147	70	37342											
BTN3A3	10384	broad.mit.edu	37	chr6	26452390	26452390	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcctgttttcagaattttGaccttggagcccactgccct	7	15	7	12	0	1	2	1	1	0	1	2	3	2	3	4	1	2	1	4	1	2	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:26452390G>T	uc003nhz.2	+	11	1686	c.1506G>T	c.(1504-1506)TTG>TTT	p.L502F	BTN3A3_uc003nia.2_Missense_Mutation_p.L460F|BTN3A3_uc011dkn.1_Missense_Mutation_p.L453F	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	502	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane					0						TCAGAATTTTGACCTTGGAGC	0.488													43	123					7.53189e-24	1.02882e-23	1	0	T	26452390	T	T	26452390	3	4	204	1	0	0	0	0	1	0	0	0	1569	1281	45	2	1540	2	BTN3A3	6	26452390	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	8851470	26452390	144662677	71	37343											
HIST1H1B	3009	broad.mit.edu	37	chr6	27835121	27835121	+	Frame_Shift_Del	DEL	C	-	-																															taaggccttcttaagggctgCcaaagaaaggccattgcgct																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:27835121delC	uc003njx.2	-	1	239	c.187delG	c.(187-189)GCAfs	p.A63fs		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	63	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						TTAAGGGCTGCCAAAGAAAGG	0.607													---	---	---								-	27835121	-	-	27835121	7	5	204	1	0	1	0	1	0	0	0	0	7162	739	26	0	497	0	HIST1H1B	6	27835121	Frame_Shift_Del	DEL	C	TCGA-CV-6948-01A-11D-1912-08	1382731	27835121	143279946	72	37344											
TRIM27	5987	broad.mit.edu	37	chr6	28871930	28871930	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcatggggcagatgatcaGaggagctgcacttttccctc	9	10	11	11	0	2	3	2	1	0	2	4	4	3	4	1	3	2	3	1	3	0	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:28871930G>C	uc003nlr.2	-	8	1818	c.1459C>G	c.(1459-1461)CTG>GTG	p.L487V	TRIM27_uc003nls.2_3'UTR|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	487	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						CAGATGATCAGAGGAGCTGCA	0.527			T	RET	papillary thyroid								57	63					0	0	0	0	C	28871930	C	C	28871930	3	2	204	1	0	0	0	0	1	0	0	0	16568	933	33	2	86	2	TRIM27	6	28871930	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	1036809	28871930	142243137	73	37345											
TRIM40	135644	broad.mit.edu	37	chr6	30105123	30105123	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaacacatgtctcatcatGaactgaccattgaaaatgcc	14	10	6	11	0	2	4	2	4	1	0	3	4	2	4	2	0	3	0	2	0	4	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:30105123G>A	uc003npk.2	+	2	696	c.310G>A	c.(310-312)GAA>AAA	p.E104K	TRIM40_uc003npl.1_RNA|TRIM40_uc003npm.2_Missense_Mutation_p.E104K	NM_138700	NP_619645	Q6P9F5	TRI40_HUMAN	tripartite motif-containing 40	104	B box-type.					intracellular	zinc ion binding			ovary(1)	1						GTCTCATCATGAACTGACCAT	0.552													61	76					0	0	0	0	A	30105123	A	A	30105123	3	1	204	1	0	0	0	0	1	0	0	0	16582	1291	45	2	312	2	TRIM40	6	30105123	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	1233193	30105123	141009944	74	37346											
PRR3	80742	broad.mit.edu	37	chr6	30530165	30530165	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccattttcacttgttcacaGacaaatccgaccgccctgtc	9	12	5	15	2	2	1	2	0	0	1	5	2	4	1	4	0	0	1	4	0	1	4	rs79542230		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:30530165G>T	uc003nqi.1	+	4	827	c.461_splice	c.e4-1	p.D154_splice	PRR3_uc003nqj.1_Splice_Site_p.D133_splice	NM_025263	NP_079539	P79522	PRR3_HUMAN	proline-rich protein 3 isoform a								nucleic acid binding|zinc ion binding				0						CTTGTTCACAGACAAATCCGA	0.453													77	199					7.63117e-38	1.06044e-37	1	0	T	30530165	T	T	30530165	5	4	204	1	0	0	0	0	0	0	1	0	12660	956	33	2	474	2	PRR3	6	30530165	Splice_Site	SNP	G	TCGA-CV-6948-01A-11D-1912-08	425042	30530165	140584902	75	37347											
DHX16	8449	broad.mit.edu	37	chr6	30624230	30624230	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagctgctccaaagccagcaGcagtgtctcatatggtggag	10	8	12	11	0	1	0	1	0	1	0	3	1	2	1	2	2	5	4	2	2	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:30624230G>T	uc003nqz.2	-	15	2580	c.2368C>A	c.(2368-2370)CTG>ATG	p.L790M	DHX16_uc003nqy.2_Missense_Mutation_p.L309M|DHX16_uc011dmo.1_Missense_Mutation_p.L730M	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	790					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						AAAGCCAGCAGCAGTGTCTCA	0.547													11	51					0.000673444	0.000803627	1	0	T	30624230	T	T	30624230	3	4	204	1	0	0	0	0	1	0	0	0	4524	962	34	4	781	4	DHX16	6	30624230	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	94065	30624230	140490837	76	37348											
HTR1B	3351	broad.mit.edu	37	chr6	78172918	78172918	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acactgtggcaatcacaaagGcattggagagcgtggtggcc	11	7	14	9	1	1	1	1	0	0	1	1	2	1	1	1	5	1	2	1	5	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:78172918G>A	uc003pil.1	-	1	203	c.203C>T	c.(202-204)GCC>GTC	p.A68V		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	68	Helical; Name=1; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	AATCACAAAGGCATTGGAGAG	0.562													74	121					0	0	0	0	A	78172918	A	A	78172918	3	1	204	1	0	0	0	0	1	0	0	0	7476	1203	42	4	973	4	HTR1B	6	78172918	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	47548688	78172918	92942149	77	37349											
SLC35F1	222553	broad.mit.edu	37	chr6	118556746	118556746	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggactcatagacctggaaGcaaattatctggtggtcaag	12	10	12	7	0	3	1	2	0	1	1	3	3	3	3	1	4	1	1	1	4	5	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:118556746G>T	uc003pxx.3	+	3	625	c.424G>T	c.(424-426)GCA>TCA	p.A142S		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	142	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		AGACCTGGAAGCAAATTATCT	0.423													23	37					1.28384e-07	1.59733e-07	1	0	T	118556746	T	T	118556746	3	4	204	1	0	0	0	0	1	0	0	0	14652	971	34	4	434	4	SLC35F1	6	118556746	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	40383828	118556746	52558321	78	37350											
TCF21	6943	broad.mit.edu	37	chr6	134210616	134210616	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacgggttgaaaatggattcGaacaaggaatttgtgacttc	13	11	12	5	2	0	2	0	2	0	0	2	6	0	4	0	3	1	1	0	3	5	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:134210616G>A	uc003qei.3	+	1	357	c.81G>A	c.(79-81)TCG>TCA	p.S27S	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Silent_p.S27S	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	27					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		AAATGGATTCGAACAAGGAAT	0.562													44	57					0	0	0	0	A	134210616	A	A	134210616	2	1	204	1	0	0	0	0	0	0	0	1	15757	1045	37	1		1	TCF21	6	134210616	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	15653870	134210616	36904451	79	37351											
FBXO30	84085	broad.mit.edu	37	chr6	146126431	146126431	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcttcacgtcccctaagtCtacttttttccaacacaatt	10	16	2	13	1	3	0	1	0	2	0	5	0	5	0	3	0	2	0	3	0	4	8			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr6:146126431C>T	uc003qla.2	-	2	1310	c.1111G>A	c.(1111-1113)GAC>AAC	p.D371N	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	371							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		TCCCCTAAGTCTACTTTTTTC	0.388													53	76					0	0	0	0	T	146126431	T	T	146126431	3	4	204	1	0	0	0	0	1	0	0	0	5772	913	32	2	1134	2	FBXO30	6	146126431	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	11915815	146126431	24988636	80	37352											
CARD11	84433	broad.mit.edu	37	chr7	2962348	2962348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcttcctctttggtgcatGtgtccaacgggacactctgc	5	12	12	12	1	2	0	0	0	2	0	4	1	4	1	2	3	3	2	2	3	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:2962348G>A	uc003smv.2	-	17	2593	c.2189C>T	c.(2188-2190)ACA>ATA	p.T730I		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	730	PDZ.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTTGGTGCATGTGTCCAACGG	0.622			Mis		DLBCL								7	48					0	0	0	0	A	2962348	A	A	2962348	3	1	204	1	0	0	0	0	1	0	0	0	2657	1377	48	4	1311	4	CARD11	7	2962348	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08		2962348	156176315	81	37353											
RADIL	55698	broad.mit.edu	37	chr7	4917456	4917456	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcacgtactggccggcctgCctggggtccagggcgtaccg	5	6	16	14	4	0	0	0	0	0	0	1	0	1	0	5	5	4	3	5	5	2	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:4917456C>T	uc003snj.1	-	2	488	c.315G>A	c.(313-315)AGG>AGA	p.R105R	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	105	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GGCCGGCCTGCCTGGGGTCCA	0.682													38	74					0	0	0	0	T	4917456	T	T	4917456	2	4	204	1	0	0	0	0	0	0	0	1	13062	738	26	4		4	RADIL	7	4917456	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	1955108	4917456	154221207	82	37354											
FSCN1	6624	broad.mit.edu	37	chr7	5632776	5632776	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccacctgggccgctaccTggcggcggacaaggacggca	8	3	15	15	4	0	0	0	0	0	0	0	2	0	2	4	6	2	2	4	6	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:5632776T>A	uc003sou.2	+	1	323	c.209T>A	c.(208-210)CTG>CAG	p.L70Q		NM_003088	NP_003079	Q16658	FSCN1_HUMAN	fascin 1	70					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			ovary(1)	1		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		GGCCGCTACCTGGCGGCGGAC	0.706													4	10					0	0	0	0	A	5632776	A	A	5632776	3	1	204	1	0	0	0	0	1	0	0	0	6101	1580	55	5	211	5	FSCN1	7	5632776	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	715320	5632776	153505887	83	37355											
RSPH10B2	728194	broad.mit.edu	37	chr7	5968017	5968017	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgatcatccttgggtctctCatatttctctggaatagagt	8	16	8	9	1	4	1	2	0	2	1	8	3	5	2	1	2	0	0	1	2	3	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:5968017C>T	uc003sph.1	-	20	2513	c.2242G>A	c.(2242-2244)GAG>AAG	p.E748K	RSPH10B2_uc003spg.1_Missense_Mutation_p.E595K|RSPH10B2_uc010ktd.1_Missense_Mutation_p.E748K|RSPH10B2_uc011jwk.1_Missense_Mutation_p.M369I	NM_173565	NP_775836	B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B	748										ovary(1)|pancreas(1)|skin(1)	3						TTGGGTCTCTCATATTTCTCT	0.443													67	172					0	0	0	0	T	5968017	T	T	5968017	3	4	204	1	0	0	0	0	1	0	0	0	13769	835	29	2	378	2	RSPH10B2	7	5968017	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	335241	5968017	153170646	84	37356											
AOAH	313	broad.mit.edu	37	chr7	36633994	36633994	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagagagttggggccagtCaagctcgttggtaagggctg	9	8	16	8	1	1	1	1	0	0	1	2	2	1	1	2	4	1	5	2	4	2	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:36633994C>G	uc003tfh.3	-	12	1290	c.889G>C	c.(889-891)GAC>CAC	p.D297H	AOAH_uc010kxf.2_Missense_Mutation_p.D297H|AOAH_uc011kba.1_Missense_Mutation_p.D265H	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	297					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						TGGGGCCAGTCAAGCTCGTTG	0.408													31	79					0	0	0	0	G	36633994	G	G	36633994	3	3	204	1	0	0	0	0	1	0	0	0	726	826	29	2	1219	2	AOAH	7	36633994	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	30665977	36633994	122504669	85	37357											
RFC2	5982	broad.mit.edu	37	chr7	73649972	73649972	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagatgccacaagtgagcaaGaatctagacaaaggagacag	18	4	11	8	0	1	5	0	1	1	4	1	6	1	5	1	1	2	1	1	1	5	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:73649972G>A	uc003uaj.2	-	10	869	c.844C>T	c.(844-846)CTT>TTT	p.L282F	RFC2_uc011kfa.1_RNA|RFC2_uc003uak.2_Missense_Mutation_p.L248F|RFC2_uc010lbp.2_Missense_Mutation_p.L211F|RFC2_uc003ual.2_Missense_Mutation_p.L181F	NM_181471	NP_852136	P35250	RFC2_HUMAN	replication factor C 2 isoform 1	282					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			liver(1)|central_nervous_system(1)	2						AAGTGAGCAAGAATCTAGACA	0.448													37	64					0	0	0	0	A	73649972	A	A	73649972	3	1	204	1	0	0	0	0	1	0	0	0	13310	942	33	2	228	2	RFC2	7	73649972	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	37015978	73649972	85488691	86	37358											
PCLO	27445	broad.mit.edu	37	chr7	82584860	82584860	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctttctttgattttttactAgaactctttctttgttgctg	5	24	5	7	0	4	2	0	1	4	1	4	2	4	2	0	0	3	2	0	0	3	9			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:82584860A>G	uc003uhx.2	-	5	5698	c.5409T>C	c.(5407-5409)TCT>TCC	p.S1803S	PCLO_uc003uhv.2_Silent_p.S1803S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1734					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATTTTTTACTAGAACTCTTTC	0.378													60	81					0	0	0	0	G	82584860	G	G	82584860	2	3	204	1	0	0	0	0	0	0	0	1	11637	407	15	5		5	PCLO	7	82584860	Silent	SNP	A	TCGA-CV-6948-01A-11D-1912-08	8934888	82584860	76553803	87	37359											
CCDC132	55610	broad.mit.edu	37	chr7	92869194	92869194	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaagggtctgaaaagccctCaagaaagcctcagtgatctt	13	10	9	9	0	4	3	2	2	2	1	4	3	4	3	2	1	2	0	2	1	5	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:92869194C>G	uc003umo.2	+	2	177	c.49C>G	c.(49-51)CAA>GAA	p.Q17E	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_5'UTR|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.Q17E|CCDC132_uc003umn.2_Missense_Mutation_p.Q17E	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	17											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			GAAAAGCCCTCAAGAAAGCCT	0.378													62	113					0	0	0	0	G	92869194	G	G	92869194	3	3	204	1	0	0	0	0	1	0	0	0	2779	827	29	2	55	2	CCDC132	7	92869194	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	10284334	92869194	66269469	88	37360											
TAF6	6878	broad.mit.edu	37	chr7	99711345	99711345	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctcccggcccccaccagaGgcgaagcggaaaggaatgaa	13	2	13	13	3	0	2	0	1	0	1	1	5	1	4	4	4	2	1	4	4	4	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:99711345G>A	uc003uti.2	-	4	372	c.291C>T	c.(289-291)GCC>GCT	p.A97A	TAF6_uc003utg.2_Silent_p.A38A|TAF6_uc003uth.2_Silent_p.A154A|TAF6_uc003utk.2_Silent_p.A97A|TAF6_uc011kji.1_Silent_p.A134A|TAF6_uc003utj.2_Silent_p.A87A|TAF6_uc003utl.2_Silent_p.A97A|TAF6_uc003utm.2_Silent_p.A97A|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	97					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCCCACCAGAGGCGAAGCGGA	0.607													5	29					0	0	0	0	A	99711345	A	A	99711345	2	1	204	1	0	0	0	0	0	0	0	1	15596	987	35	4		4	TAF6	7	99711345	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	6842151	99711345	59427318	89	37361											
MUC17	140453	broad.mit.edu	37	chr7	100677499	100677499	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatgcctgacagcaccacGccggtagtcagttctgaggc	9	8	12	12	2	2	2	1	2	1	0	2	2	2	2	3	2	2	4	3	2	2	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:100677499G>A	uc003uxp.1	+	3	2855	c.2802G>A	c.(2800-2802)ACG>ACA	p.T934T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	934	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|13.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAGCACCACGCCGGTAGTCA	0.512													257	346					0	0	0	0	A	100677499	A	A	100677499	2	1	204	1	0	0	0	0	0	0	0	1	10027	1074	38	1		1	MUC17	7	100677499	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	966154	100677499	58461164	90	37362											
EXOC4	60412	broad.mit.edu	37	chr7	133689722	133689722	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggggaactatgccattgtGgctaatgtggaaagtatgga	12	10	15	4	0	0	0	0	0	0	0	0	4	0	3	1	5	2	2	1	5	5	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:133689722G>T	uc003vrk.2	+	16	2441	c.2406G>T	c.(2404-2406)GTG>GTT	p.V802V	EXOC4_uc011kpo.1_Silent_p.V701V|EXOC4_uc003vrl.2_Silent_p.V412V|EXOC4_uc011kpp.1_Silent_p.V334V|EXOC4_uc011kpq.1_Silent_p.V90V	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	802					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				ATGCCATTGTGGCTAATGTGG	0.463													7	99					2.0095e-06	2.49054e-06	1	0	T	133689722	T	T	133689722	2	4	204	1	0	0	0	0	0	0	0	1	5330	1335	47	4		4	EXOC4	7	133689722	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	33012223	133689722	25448941	91	37363											
UBN2	254048	broad.mit.edu	37	chr7	138968956	138968956	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcactagttgcccagggtaGccactccagcactaacagcc	10	7	9	15	0	0	0	0	0	0	0	1	0	1	0	4	1	6	4	4	1	3	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:138968956G>C	uc011kqr.1	+	15	3305	c.3305G>C	c.(3304-3306)AGC>ACC	p.S1102T		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1102	Ser-rich.									ovary(1)|skin(1)	2						GCCCAGGGTAGCCACTCCAGC	0.473													59	66					0	0	0	0	C	138968956	C	C	138968956	3	2	204	1	0	0	0	0	1	0	0	0	16961	971	34	4	3363	4	UBN2	7	138968956	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	5279234	138968956	20169707	92	37364											
HTR5A	3361	broad.mit.edu	37	chr7	154862903	154862903	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggtcatgccgctgagcctGgtgcacgagctgtccgggcg	4	8	16	13	4	1	1	1	1	0	0	2	2	2	1	3	3	4	3	3	3	0	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr7:154862903G>A	uc003wlu.1	+	1	358	c.294G>A	c.(292-294)CTG>CTA	p.L98L	uc011kvt.1_Silent_p.T37T|uc003wlt.2_Silent_p.T37T	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	98	Helical; Name=2; (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CGCTGAGCCTGGTGCACGAGC	0.672													8	31					0	0	0	0	A	154862903	A	A	154862903	2	1	204	1	0	0	0	0	0	0	0	1	7489	1335	47	4		4	HTR5A	7	154862903	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	15893947	154862903	4275760	93	37365											
SGK223	157285	broad.mit.edu	37	chr8	8234394	8234394	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctcctcttcacctacctCggagttctggctcacaggcc	6	11	8	16	1	5	0	2	0	3	0	7	1	5	1	4	3	1	2	4	3	1	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:8234394C>A	uc003wsh.3	-	2	1525	c.1525G>T	c.(1525-1527)GAG>TAG	p.E509*		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	509							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TCACCTACCTCGGAGTTCTGG	0.652													13	8					0.000219431	0.000264803	1	0	A	8234394	A	A	8234394	4	1	204	1	0	0	0	0	0	1	0	0	14275	893	31	3	2699	3	SGK223	8	8234394	Nonsense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08		8234394	138129628	94	37366											
RP1L1	94137	broad.mit.edu	37	chr8	10467489	10467503	+	In_Frame_Del	DEL	CTGCACCCCCTCTTC	-	-																															ccttctttaacttcctctaaCtgcaccccctcttcttgcag																								rs146799763	by1000genomes	TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:10467489_10467503delCTGCACCCCCTCTTC	uc003wtc.2	-	4	4334_4348	c.4105_4119delGAAGAGGGGGTGCAG	c.(4105-4119)GAAGAGGGGGTGCAGdel	p.EEGVQ1369del		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1369_1373					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTTCCTCTAACTGCACCCCCTCTTCTTGCAGCCct	0.307													---	---	---								-	10467503	-	-	10467489	7	5	204	1	0	1	0	1	0	0	0	0	13598	564	20	0	3087	0	RP1L1	8	10467489	In_Frame_Del	DEL	CTGCACCCCCTCTTC	TCGA-CV-6948-01A-11D-1912-08	2233095	10467489	135896533	95	37367											
BAG4	9530	broad.mit.edu	37	chr8	38034614	38034614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgatggctactatccctcggGaggcgcctggccagagcctg	6	7	14	14	3	0	1	0	0	0	1	2	3	1	2	4	4	2	1	4	4	2	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:38034614G>A	uc003xky.1	+	1	509	c.227G>A	c.(226-228)GGA>GAA	p.G76E	LSM1_uc003xkw.2_5'Flank|LSM1_uc003xkx.2_5'Flank|BAG4_uc003xkz.1_Missense_Mutation_p.G76E	NM_004874	NP_004865	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	76					anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				TATCCCTCGGGAGGCGCCTGG	0.706													21	6					0	0	0	0	A	38034614	A	A	38034614	3	1	204	1	0	0	0	0	1	0	0	0	1291	1174	41	2	229	2	BAG4	8	38034614	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	27567125	38034614	108329408	96	37368											
XKR4	114786	broad.mit.edu	37	chr8	56270346	56270346	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatgcggatgtgagtatgctGcatttgctagccacctttct	7	15	10	9	1	1	1	0	1	1	0	1	2	1	2	2	1	5	4	2	1	3	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:56270346G>T	uc003xsf.2	+	2	947	c.915G>T	c.(913-915)CTG>CTT	p.L305L		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	305						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TGAGTATGCTGCATTTGCTAG	0.473													43	37					2.19962e-31	3.03038e-31	1	0	T	56270346	T	T	56270346	2	4	204	1	0	0	0	0	0	0	0	1	17501	1306	46	4		4	XKR4	8	56270346	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	18235732	56270346	90093676	97	37369											
CLVS1	157807	broad.mit.edu	37	chr8	62212732	62212732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaaacttcaaggcagatgatCccggcattaagagggctctg	13	8	11	9	1	2	3	1	1	1	2	3	3	3	3	1	3	1	3	1	3	4	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:62212732C>T	uc003xuh.2	+	2	670	c.346C>T	c.(346-348)CCC>TCC	p.P116S	CLVS1_uc003xug.2_Missense_Mutation_p.P116S|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Missense_Mutation_p.P116S	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	116					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						GGCAGATGATCCCGGCATTAA	0.507													21	60					0	0	0	0	T	62212732	T	T	62212732	3	4	204	1	0	0	0	0	1	0	0	0	3586	855	30	2	348	2	CLVS1	8	62212732	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	5942386	62212732	84151290	98	37370											
PREX2	80243	broad.mit.edu	37	chr8	68934274	68934274	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttacatgaattcacagaaaGacaagtttcgtatctatgat	15	13	6	7	1	2	4	1	2	1	2	3	4	2	4	0	0	1	2	0	0	6	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:68934274G>A	uc003xxv.1	+	4	367	c.340G>A	c.(340-342)GAC>AAC	p.D114N	PREX2_uc003xxu.1_Missense_Mutation_p.D114N|PREX2_uc011lez.1_Missense_Mutation_p.D49N	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	114	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TTCACAGAAAGACAAGTTTCG	0.259													19	29					0	0	0	0	A	68934274	A	A	68934274	3	1	204	1	0	0	0	0	1	0	0	0	12539	942	33	2	354	2	PREX2	8	68934274	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	6721542	68934274	77429748	99	37371											
E2F5	1875	broad.mit.edu	37	chr8	86121536	86121536	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttcctcccagtccttgactCcagtgactccacagaaatcc	9	10	5	17	0	0	3	0	2	0	1	6	3	6	3	6	0	0	0	6	0	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:86121536C>G	uc003ycz.3	+	6	812	c.775C>G	c.(775-777)CCA>GCA	p.P259A	E2F5_uc003yda.3_Missense_Mutation_p.P259A|E2F5_uc010mab.2_Missense_Mutation_p.P98A|E2F5_uc003ydb.3_Missense_Mutation_p.P78A	NM_001951	NP_001942	Q15329	E2F5_HUMAN	E2F transcription factor 5 isoform 1	259					G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1						GTCCTTGACTCCAGTGACTCC	0.488													5	94					0	0	0	0	G	86121536	G	G	86121536	3	3	204	1	0	0	0	0	1	0	0	0	4892	855	30	2	797	2	E2F5	8	86121536	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	17187262	86121536	60242486	100	37372											
PSKH2	85481	broad.mit.edu	37	chr8	87076791	87076791	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttattgcaaaaggtttcttGgtggtcttctgctctaccct	6	18	8	9	0	4	0	0	0	4	0	4	0	4	0	1	3	3	3	1	3	4	7			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:87076791G>T	uc011lfy.1	-	2	255	c.255C>A	c.(253-255)ACC>ACA	p.T85T		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	85	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			AAGGTTTCTTGGTGGTCTTCT	0.483													28	109					8.58068e-18	1.15731e-17	1	0	T	87076791	T	T	87076791	2	4	204	1	0	0	0	0	0	0	0	1	12727	1335	47	4		4	PSKH2	8	87076791	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	955255	87076791	59287231	101	37373											
FAM82B	51115	broad.mit.edu	37	chr8	87519250	87519250	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggcatgaaccacagcaGcctgagagataacctggtaa	13	7	11	10	0	0	3	0	2	0	1	0	4	0	3	3	2	4	3	3	2	3	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:87519250G>A	uc003ydu.2	-	2	381	c.221C>T	c.(220-222)GCT>GTT	p.A74V	FAM82B_uc011lfz.1_Missense_Mutation_p.A74V|FAM82B_uc011lga.1_Missense_Mutation_p.A74V	NM_016033	NP_057117	Q96DB5	RMD1_HUMAN	regulator of microtubule dynamics 1	74						microtubule|spindle pole	binding			ovary(1)	1						AACCACAGCAGCCTGAGAGAT	0.368													93	150					0	0	0	0	A	87519250	A	A	87519250	3	1	204	1	0	0	0	0	1	0	0	0	5664	971	34	4	759	4	FAM82B	8	87519250	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	442459	87519250	58844772	102	37374											
RUNX1T1	862	broad.mit.edu	37	chr8	92999130	92999130	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttacatggtcaagatgtttCcactcttctgcccattctct	7	16	5	13	0	4	1	1	0	3	1	6	1	5	1	2	1	2	1	2	1	2	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:92999130C>A	uc003yfd.2	-	7	1146	c.1062G>T	c.(1060-1062)TGG>TGT	p.W354C	RUNX1T1_uc003yfc.1_Missense_Mutation_p.W327C|RUNX1T1_uc003yfe.1_Missense_Mutation_p.W317C|RUNX1T1_uc010mao.2_Missense_Mutation_p.W327C|RUNX1T1_uc011lgi.1_Missense_Mutation_p.W365C|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Missense_Mutation_p.W317C	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	354	Important for oligomerization.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAAGATGTTTCCACTCTTCTG	0.378													6	215					0.00116845	0.00138915	1	0	A	92999130	A	A	92999130	3	1	204	1	0	0	0	0	1	0	0	0	13812	856	30	2	772	2	RUNX1T1	8	92999130	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	5479880	92999130	53364892	103	37375											
FAM92A1	137392	broad.mit.edu	37	chr8	94713483	94713483	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaaacaactgcaaacagctGtctcaaatgtggagaagcat	16	7	9	9	1	1	1	1	0	1	1	2	3	1	1	0	1	6	3	0	1	5	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:94713483G>T	uc010maq.2	+	2	161	c.58G>T	c.(58-60)GTC>TTC	p.V20F	FAM92A1_uc003yfu.1_RNA|FAM92A1_uc003yfv.3_RNA	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	20											0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GCAAACAGCTGTCTCAAATGT	0.453													10	41					2.80697e-09	3.53349e-09	1	0	T	94713483	T	T	94713483	3	4	204	1	0	0	0	0	1	0	0	0	5684	1377	48	4	64	4	FAM92A1	8	94713483	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	1714353	94713483	51650539	104	37376											
VPS13B	157680	broad.mit.edu	37	chr8	100513954	100513954	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaggaatcaccattctcaGattctgtgaccttggaacaa	12	11	9	9	0	3	3	2	2	2	1	4	5	3	5	2	2	1	0	2	2	3	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:100513954G>A	uc003yiv.2	+	26	4021	c.3910G>A	c.(3910-3912)GAT>AAT	p.D1304N	VPS13B_uc003yiw.2_Missense_Mutation_p.D1304N|VPS13B_uc003yiu.1_Missense_Mutation_p.D1304N|VPS13B_uc003yix.1_Missense_Mutation_p.D774N	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1304					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ACCATTCTCAGATTCTGTGAC	0.368													95	129					0	0	0	0	A	100513954	A	A	100513954	3	1	204	1	0	0	0	0	1	0	0	0	17258	942	33	2	4131	2	VPS13B	8	100513954	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	5800471	100513954	45850068	105	37377											
EIF3E	3646	broad.mit.edu	37	chr8	109252300	109252300	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgtggttcttttctctctCaaagctaattaaaaatgcag	12	15	6	8	0	3	0	1	0	3	0	5	0	3	0	0	1	2	3	0	1	5	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:109252300C>G	uc003ymu.2	-	3	238	c.210G>C	c.(208-210)TTG>TTC	p.L70F	EIF3E_uc003ymt.2_Missense_Mutation_p.L21F|EIF3E_uc003ymv.2_5'UTR|EIF3E_uc010mci.1_Missense_Mutation_p.L70F|EIF3E_uc010mcj.1_Missense_Mutation_p.L70F	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	70	Sufficient for interaction with TRIM27.|Sufficient for interaction with EPAS1.				negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			TTTTCTCTCTCAAAGCTAATT	0.358													30	126					0	0	0	0	G	109252300	G	G	109252300	3	3	204	1	0	0	0	0	1	0	0	0	5039	825	29	2	1171	2	EIF3E	8	109252300	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	8738346	109252300	37111722	106	37378											
CSMD3	114788	broad.mit.edu	37	chr8	113323395	113323395	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggtgtactacagtagaaaGcttttcaaaagaaaaaaaaa	20	9	7	5	0	1	2	1	0	0	2	1	2	1	2	0	1	3	3	0	1	10	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:113323395G>T	uc003ynu.2	-	50	7856	c.7697C>A	c.(7696-7698)GCT>GAT	p.A2566D	CSMD3_uc003yns.2_Missense_Mutation_p.A1768D|CSMD3_uc003ynt.2_Missense_Mutation_p.A2526D|CSMD3_uc011lhx.1_Missense_Mutation_p.A2462D|CSMD3_uc003ynw.1_Missense_Mutation_p.A277D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2566	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACAGTAGAAAGCTTTTCAAAA	0.398										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	59					4.93089e-13	6.40816e-13	1	0	T	113323395	T	T	113323395	3	4	204	1	0	0	0	0	1	0	0	0	3963	985	34	4	3514	4	CSMD3	8	113323395	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	4071095	113323395	33040627	107	37379											
MYC	4609	broad.mit.edu	37	chr8	128753051	128753051	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagttggaaaacaatgaaaaGgcccccaaggtagttatcct	15	8	10	8	0	0	1	0	1	0	0	1	3	1	2	3	3	1	3	3	3	8	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:128753051G>C	uc003ysi.2	+	3	1737	c.1212G>C	c.(1210-1212)AAG>AAC	p.K404N		NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	389	Helix-loop-helix motif.				branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		ACAATGAAAAGGCCCCCAAGG	0.502		3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL								64	305					0	0	0	0	C	128753051	C	C	128753051	3	2	204	1	0	0	0	0	1	0	0	0	10069	991	35	4	1222	4	MYC	8	128753051	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	15429656	128753051	17610971	108	37380											
ASAP1	50807	broad.mit.edu	37	chr8	131073299	131073299	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtctagggagagatgatcTgttttccttagtgccactgt	7	16	11	7	0	2	2	0	1	2	1	3	4	3	3	2	1	1	1	2	1	2	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:131073299T>C	uc003yta.1	-	27	2746	c.2718A>G	c.(2716-2718)ACA>ACG	p.T906T	ASAP1_uc003ysz.1_Silent_p.T717T|ASAP1_uc011liw.1_Silent_p.T899T	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	906	Pro-rich.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						AGAGATGATCTGTTTTCCTTA	0.493													83	271					0	0	0	0	C	131073299	C	C	131073299	2	2	204	1	0	0	0	0	0	0	0	1	1012	1567	55	5		5	ASAP1	8	131073299	Silent	SNP	T	TCGA-CV-6948-01A-11D-1912-08	2320248	131073299	15290723	109	37381											
OC90	729330	broad.mit.edu	37	chr8	133036916	133036916	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctgcccagggcacccgaGtctgcttggggacttgaggc	5	8	16	12	1	1	1	0	1	1	0	1	3	1	2	2	5	2	3	2	5	0	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:133036916G>A	uc003ytg.2	-	13	1246	c.1246C>T	c.(1246-1248)CTC>TTC	p.L416F	OC90_uc011lix.1_Missense_Mutation_p.L416F	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	432	Phospholipase A2-like 3.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GGGCACCCGAGTCTGCTTGGG	0.627													10	36					0	0	0	0	A	133036916	A	A	133036916	3	1	204	1	0	0	0	0	1	0	0	0	10868	1029	36	4	191	4	OC90	8	133036916	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	1963617	133036916	13327106	110	37382											
PLEC	5339	broad.mit.edu	37	chr8	144992466	144992479	+	Frame_Shift_Del	DEL	GCTGGGCTCTGACA	-	-																															tccacgtagctgcgcacctcGctgggctctgacagctggtc																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr8:144992466_144992479delGCTGGGCTCTGACA	uc003zaf.1	-	32	12091_12104	c.11921_11934delTGTCAGAGCCCAGC	c.(11920-11934)CTGTCAGAGCCCAGCfs	p.L3974fs	PLEC_uc003zab.1_Frame_Shift_Del_p.L3837fs|PLEC_uc003zac.1_Frame_Shift_Del_p.L3841fs|PLEC_uc003zad.2_Frame_Shift_Del_p.L3837fs|PLEC_uc003zae.1_Frame_Shift_Del_p.L3805fs|PLEC_uc003zag.1_Frame_Shift_Del_p.L3815fs|PLEC_uc003zah.2_Frame_Shift_Del_p.L3823fs|PLEC_uc003zaj.2_Frame_Shift_Del_p.L3864fs	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3974_3978	Plectin 21.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TGCGCACCTCGCTGGGCTCTGACAGCTGGTCGTG	0.692													---	---	---								-	144992479	-	-	144992466	7	5	204	1	0	1	0	1	0	0	0	0	12107	1078	38	0	2124	0	PLEC	8	144992466	Frame_Shift_Del	DEL	GCTGGGCTCTGACA	TCGA-CV-6948-01A-11D-1912-08	11955550	144992466	1371556	111	37383											
KDM4C	23081	broad.mit.edu	37	chr9	6805612	6805612	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttttaggtgattcctcctaAggagtggaagccaagacagt	11	12	11	7	0	0	2	0	1	0	1	2	4	2	4	3	3	1	0	3	3	4	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:6805612A>T	uc003zkh.2	+	3	738	c.158A>T	c.(157-159)AAG>ATG	p.K53M	KDM4C_uc010mhu.2_Missense_Mutation_p.K75M|KDM4C_uc010mhw.2_Missense_Mutation_p.K53M|KDM4C_uc011lmi.1_Missense_Mutation_p.K53M|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.K53M|KDM4C_uc011lmk.1_Intron|KDM4C_uc010mhv.2_Missense_Mutation_p.K53M	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	53	JmjN.				positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						ATTCCTCCTAAGGAGTGGAAG	0.358													19	4					0	0	0	0	T	6805612	T	T	6805612	3	4	204	1	0	0	0	0	1	0	0	0	8169	72	3	5	234	5	KDM4C	9	6805612	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08		6805612	134407819	112	37384											
LRRC19	64922	broad.mit.edu	37	chr9	26999638	26999640	+	In_Frame_Del	DEL	ATA	-	-																															agaagactggattttgtctgAtaataatatcatggagaggg																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:26999638_26999640delATA	uc003zqh.2	-	2	164_166	c.53_55delTAT	c.(52-57)TTATCA>TCA	p.L18del	IFT74_uc010mja.2_Intron|IFT74_uc010mjb.2_Intron|IFT74_uc003zqf.3_Intron|IFT74_uc003zqg.3_Intron	NM_022901	NP_075052	Q9H756	LRC19_HUMAN	leucine rich repeat containing 19 precursor	18						integral to membrane					0		all_neural(11;1.81e-09)		Lung(218;1.06e-05)|LUSC - Lung squamous cell carcinoma(38;0.0001)		ATTTTGTCTGATAATAATATCAT	0.291													---	---	---								-	26999640	-	-	26999638	7	5	204	1	0	1	0	1	0	0	0	0	9025	333	12	0	1073	0	LRRC19	9	26999638	In_Frame_Del	DEL	ATA	TCGA-CV-6948-01A-11D-1912-08	20194026	26999638	114213793	113	37385											
CYLC2	1539	broad.mit.edu	37	chr9	105767308	105767308	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacacaacagattcggaatCagaattaaaacaaggaaaaa	22	5	8	6	1	1	2	1	0	0	2	2	5	1	5	0	3	2	0	0	3	8	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:105767308C>G	uc004bbs.2	+	5	465	c.395C>G	c.(394-396)TCA>TGA	p.S132*		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	132	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				GATTCGGAATCAGAATTAaaa	0.179													6	27					0	0	0	0	G	105767308	G	G	105767308	4	3	204	1	0	0	0	0	0	1	0	0	4159	838	29	2	413	2	CYLC2	9	105767308	Nonsense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	78767670	105767308	35446123	114	37386											
PTPN3	5774	broad.mit.edu	37	chr9	112168829	112168829	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacttggtcatgcgtgtgttCtgagatgtcccggccattga	6	13	12	10	2	2	2	1	2	1	1	3	3	3	2	2	2	1	1	2	2	0	3	rs59324117	byFrequency	TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:112168829C>G	uc004bed.2	-	18	1817	c.1705G>C	c.(1705-1707)GAA>CAA	p.E569Q	PTPN3_uc004beb.2_Missense_Mutation_p.E438Q|PTPN3_uc004bec.2_Missense_Mutation_p.E393Q|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.E524Q|PTPN3_uc011lwh.1_Missense_Mutation_p.E415Q|PTPN3_uc011lwd.1_Missense_Mutation_p.E37Q|PTPN3_uc011lwe.1_Missense_Mutation_p.E282Q|PTPN3_uc011lwf.1_Missense_Mutation_p.E237Q	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	569	PDZ.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						TGCGTGTGTTCTGAGATGTCC	0.557													87	134					0	0	0	0	G	112168829	G	G	112168829	3	3	204	1	0	0	0	0	1	0	0	0	12854	922	32	2	1072	2	PTPN3	9	112168829	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	6401521	112168829	29044602	115	37387											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112899008	112899008	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagctcacggtgttcttcccGagatggagagttcactctca	8	11	10	12	2	4	2	3	0	2	2	6	4	5	2	1	2	1	3	1	2	0	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:112899008G>A	uc004bei.2	+	9	2072	c.1880G>A	c.(1879-1881)CGA>CAA	p.R627Q	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.R395Q|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.R395Q|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.R205Q|AKAP2_uc011lwi.1_Missense_Mutation_p.R253Q|AKAP2_uc004bem.2_Missense_Mutation_p.R253Q|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.R213Q|AKAP2_uc011lwj.1_Missense_Mutation_p.R164Q|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.R164Q	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	164							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						TGTTCTTCCCGAGATGGAGAG	0.572													47	9					0	0	0	0	A	112899008	A	A	112899008	3	1	204	1	0	0	0	0	1	0	0	0	11464	1058	37	1	1214	1	PALM2-AKAP2	9	112899008	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	730179	112899008	28314423	116	37388											
DBC1	1620	broad.mit.edu	37	chr9	121929820	121929820	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtggaccgtctcgaaaaatgTtttccaccgattgcccagca	10	10	9	12	3	1	0	0	0	1	0	3	3	2	1	4	1	2	2	4	1	2	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr9:121929820T>G	uc004bkc.2	-	8	2284	c.1828A>C	c.(1828-1830)ACA>CCA	p.T610P		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	610					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TCGAAAAATGTTTTCCACCGA	0.557													116	29					0	0	0	0	G	121929820	G	G	121929820	3	3	204	1	0	0	0	0	1	0	0	0	4264	1725	60	5	461	5	DBC1	9	121929820	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	9030812	121929820	19283611	117	37389											
LARP4B	23185	broad.mit.edu	37	chr10	863817	863817	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttggtggcgttggagactGtgtctggctgctctgcaaca	5	13	14	9	1	2	1	0	0	2	1	2	2	2	1	0	4	3	4	0	4	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:863817G>A	uc001ifs.1	-	14	1584	c.1543C>T	c.(1543-1545)CAG>TAG	p.Q515*		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	515							nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						GTTGGAGACTGTGTCTGGCTG	0.557													23	49					0	0	0	0	A	863817	A	A	863817	4	1	204	1	0	0	0	0	0	1	0	0	8671	1386	48	4	689	4	LARP4B	10	863817	Nonsense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08		863817	134670930	118	37390											
IL2RA	3559	broad.mit.edu	37	chr10	6061875	6061875	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctcactctcaggacggcCttcggggcttgcctgaggct	5	10	13	13	2	2	1	2	1	2	0	5	2	2	2	2	5	1	2	2	5	0	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:6061875C>T	uc001iiz.1	-	5	772	c.613G>A	c.(613-615)GGC>AGC	p.G205S	IL2RA_uc009xih.1_Missense_Mutation_p.G133S|IL2RA_uc001ija.1_Intron	NM_000417	NP_000408	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha chain precursor	205	Extracellular (Potential).				cell proliferation	integral to membrane	interleukin-2 receptor activity			ovary(1)|skin(1)	2					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	TCAGGACGGCCTTCGGGGCTT	0.597													30	59					0	0	0	0	T	6061875	T	T	6061875	3	4	204	1	0	0	0	0	1	0	0	0	7725	681	24	4	221	4	IL2RA	10	6061875	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	5198058	6061875	129472872	119	37391											
MCM10	55388	broad.mit.edu	37	chr10	13240697	13240697	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgtgccctagctgaggatGaattggagcctgccaggaaa	10	9	13	9	0	0	2	0	2	0	0	0	5	0	5	3	3	4	1	3	3	3	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:13240697G>T	uc001ima.2	+	16	2232	c.2131G>T	c.(2131-2133)GAA>TAA	p.E711*	MCM10_uc001imb.2_Nonsense_Mutation_p.E710*|MCM10_uc001imc.2_Nonsense_Mutation_p.E710*	NM_182751	NP_877428	Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	711					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						AGCTGAGGATGAATTGGAGCC	0.458													45	61					8.94452e-30	1.22701e-29	1	0	T	13240697	T	T	13240697	4	4	204	1	0	0	0	0	0	1	0	0	9438	1291	45	2	2189	2	MCM10	10	13240697	Nonsense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	7178822	13240697	122294050	120	37392											
NPFFR1	64106	broad.mit.edu	37	chr10	72020461	72020461	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacatgccctgcaccaagccGctcatcttgcatgtggcatt	8	10	9	14	1	2	0	1	0	1	0	2	1	2	0	3	1	4	4	3	1	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:72020461G>A	uc010qjk.1	-	2	357	c.351C>T	c.(349-351)AGC>AGT	p.S117S		NM_022146	NP_071429	Q9GZQ6	NPFF1_HUMAN	neuropeptide FF receptor 1	119	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	neuropeptide receptor activity				0						GCACCAAGCCGCTCATCTTGC	0.532													7	17					0	0	0	0	A	72020461	A	A	72020461	2	1	204	1	0	0	0	0	0	0	0	1	10631	1078	38	1		1	NPFFR1	10	72020461	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	58779764	72020461	63514286	121	37393											
KIAA0913	23053	broad.mit.edu	37	chr10	75552076	75552076	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactgggtggggctggcagTgggagcaagggctcagcagg	7	5	21	8	0	1	0	1	0	0	0	1	1	1	1	0	7	2	6	0	7	1	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:75552076T>A	uc009xrl.2	+	10	1811	c.1779T>A	c.(1777-1779)AGT>AGA	p.S593R	KIAA0913_uc001jve.2_Missense_Mutation_p.S593R|KIAA0913_uc001jvf.2_Missense_Mutation_p.S593R|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.S16R|KIAA0913_uc010qkr.1_Missense_Mutation_p.S16R|KIAA0913_uc001jvj.2_Missense_Mutation_p.S16R	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	593	Gly-rich.						zinc ion binding			breast(1)	1	Prostate(51;0.0112)					GGGCTGGCAGTGGGAGCAAGG	0.642													13	17					0	0	0	0	A	75552076	A	A	75552076	3	1	204	1	0	0	0	0	1	0	0	0	8239	1693	59	5	1817	5	KIAA0913	10	75552076	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	3531615	75552076	59982671	122	37394											
LIPN	643418	broad.mit.edu	37	chr10	90521213	90521213	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatctgtggaactttaaaTgctggtggattccttgattt	8	18	10	5	0	1	2	0	2	1	0	2	4	2	4	1	3	2	1	1	3	3	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:90521213T>C	uc010qmw.1	+	1	51	c.51T>C	c.(49-51)AAT>AAC	p.N17N		NM_001102469	NP_001095939	Q5VXI9	LIPN_HUMAN	lipase-like, ab-hydrolase domain containing 4	17					lipid catabolic process	extracellular region	hydrolase activity				0		Colorectal(252;0.0161)		Colorectal(12;4.83e-05)|COAD - Colon adenocarcinoma(12;6.5e-05)		GAACTTTAAATGCTGGTGGAT	0.343													39	62					0	0	0	0	C	90521213	C	C	90521213	2	2	204	1	0	0	0	0	0	0	0	1	8870	1461	51	5		5	LIPN	10	90521213	Silent	SNP	T	TCGA-CV-6948-01A-11D-1912-08	14969137	90521213	45013534	123	37395											
TLX1	3195	broad.mit.edu	37	chr10	102891411	102891411	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tggctgcatgggacccgcctCgcgcctccaggacggagaat	7	6	14	14	4	0	1	0	0	0	1	2	4	1	3	4	4	1	2	4	4	1	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:102891411C>G	uc001ksw.2	+	1	351	c.113C>G	c.(112-114)TCG>TGG	p.S38W	TLX1NB_uc001ksv.2_5'Flank	NM_005521	NP_005512	P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	38						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GGACCCGCCTCGCGCCTCCAG	0.706			T	TRB@|TRD@	T-ALL								8	15					0	0	0	0	G	102891411	G	G	102891411	3	3	204	1	0	0	0	0	1	0	0	0	16025	893	31	3	115	3	TLX1	10	102891411	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	12370198	102891411	32643336	124	37396											
ACSL5	51703	broad.mit.edu	37	chr10	114158684	114158684	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcacggaagggggtttcccAgaagaacaatgacctaacaa	16	5	11	9	1	0	3	0	1	0	2	1	4	1	4	2	3	3	2	2	3	6	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:114158684A>G	uc001kzs.2	+	3	323	c.182A>G	c.(181-183)CAG>CGG	p.Q61R	ACSL5_uc001kzt.2_Missense_Mutation_p.Q61R|ACSL5_uc001kzu.2_Missense_Mutation_p.Q117R|ACSL5_uc009xxz.2_Missense_Mutation_p.Q61R	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	61	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		GGGGTTTCCCAGAAGAACAAT	0.463													55	73					0	0	0	0	G	114158684	G	G	114158684	3	3	204	1	0	0	0	0	1	0	0	0	180	188	7	5	360	5	ACSL5	10	114158684	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	11267273	114158684	21376063	125	37397											
ACSL5	51703	broad.mit.edu	37	chr10	114171725	114171725	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctggctcatatgtttgaGaggattgtacaggtgagtgt	8	14	13	6	0	2	2	1	2	1	1	2	4	2	3	1	3	1	3	1	3	2	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr10:114171725G>C	uc001kzs.2	+	11	1077	c.936G>C	c.(934-936)GAG>GAC	p.E312D	ACSL5_uc001kzt.2_Missense_Mutation_p.E312D|ACSL5_uc001kzu.2_Missense_Mutation_p.E368D|ACSL5_uc009xxz.2_Missense_Mutation_p.E312D|ACSL5_uc010qrj.1_Missense_Mutation_p.E94D	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	312	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		ATATGTTTGAGAGGATTGTAC	0.478													7	139					0	0	0	0	C	114171725	C	C	114171725	3	2	204	1	0	0	0	0	1	0	0	0	180	933	33	2	1146	2	ACSL5	10	114171725	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	13041	114171725	21363022	126	37398											
NLRP14	338323	broad.mit.edu	37	chr11	7063670	7063670	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaaattttgcatcacttGggacaagaagtctttggctg	12	12	11	6	0	2	1	1	0	1	1	2	3	2	3	0	3	1	2	0	3	4	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:7063670G>T	uc001mfb.1	+	4	736	c.413G>T	c.(412-414)TGG>TTG	p.W138L		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	138					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TGCATCACTTGGGACAAGAAG	0.363													30	16					1.39806e-14	1.83174e-14	1	0	T	7063670	T	T	7063670	3	4	204	1	0	0	0	0	1	0	0	0	10530	1357	47	4	423	4	NLRP14	11	7063670	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08		7063670	127942846	127	37399											
OR10A6	390093	broad.mit.edu	37	chr11	7950014	7950014	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actcaggtccaccacagataAgttcaggagaaacaggtaca	16	6	9	10	0	2	2	2	0	0	2	3	3	3	2	2	3	2	2	2	3	3	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:7950014A>C	uc010rbh.1	-	1	196	c.196T>G	c.(196-198)TTA>GTA	p.L66V		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACCACAGATAAGTTCAGGAGA	0.443													61	29					0	0	0	0	C	7950014	C	C	7950014	3	2	204	1	0	0	0	0	1	0	0	0	10948	69	3	5	751	5	OR10A6	11	7950014	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	886344	7950014	127056502	128	37400											
NAV2	89797	broad.mit.edu	37	chr11	19970445	19970445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactgagtcaggtcgctatGtgtactccgcccctctgaga	8	10	10	13	2	2	2	1	2	1	1	4	3	3	2	3	1	1	2	3	1	2	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:19970445G>A	uc010rdm.1	+	11	2894	c.2533G>A	c.(2533-2535)GTG>ATG	p.V845M	NAV2_uc001mpp.2_Missense_Mutation_p.V758M|NAV2_uc001mpr.3_Missense_Mutation_p.V822M	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	845						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						AGGTCGCTATGTGTACTCCGC	0.612													40	14					0	0	0	0	A	19970445	A	A	19970445	3	1	204	1	0	0	0	0	1	0	0	0	10237	1377	48	4	2581	4	NAV2	11	19970445	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	12020431	19970445	115036071	129	37401											
RAG2	5897	broad.mit.edu	37	chr11	36614509	36614509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcatcttcttcatcatcttCattataggtgtcaaattcat	10	18	3	10	0	9	0	6	0	3	0	9	0	9	0	0	1	0	0	0	1	3	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:36614509C>T	uc001mwv.3	-	2	1398	c.1210G>A	c.(1210-1212)GAA>AAA	p.E404K	RAG1_uc001mwt.2_Intron|C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	404					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TCATCATCTTCATTATAGGTG	0.403									Familial_Hemophagocytic_Lymphohistiocytosis				38	24					0	0	0	0	T	36614509	T	T	36614509	3	4	204	1	0	0	0	0	1	0	0	0	13070	835	29	2	377	2	RAG2	11	36614509	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	16644064	36614509	98392007	130	37402											
FAM111B	374393	broad.mit.edu	37	chr11	58892341	58892341	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaacagtccatggtggaTgaagtatctggaaaagtctt	14	10	12	5	0	2	1	0	1	2	0	3	4	3	4	1	4	1	1	1	4	6	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:58892341T>A	uc001nnl.2	+	4	1014	c.771T>A	c.(769-771)GAT>GAA	p.D257E	FAM111B_uc001nnm.2_Missense_Mutation_p.D227E|FAM111B_uc010rko.1_Missense_Mutation_p.D227E	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	257							catalytic activity			ovary(2)	2						CCATGGTGGATGAAGTATCTG	0.343													4	31					0	0	0	0	A	58892341	A	A	58892341	3	1	204	1	0	0	0	0	1	0	0	0	5428	1461	51	5	777	5	FAM111B	11	58892341	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	22277832	58892341	76114175	131	37403											
B3GAT3	26229	broad.mit.edu	37	chr11	62384617	62384617	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctcgacaccacggggatGaacccagccaggctcgccct	8	5	11	17	3	0	1	0	1	0	0	2	3	0	2	4	3	3	2	4	3	1	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:62384617G>A	uc001ntw.2	-	3	489	c.460C>T	c.(460-462)CAT>TAT	p.H154Y	B3GAT3_uc009ynz.2_Missense_Mutation_p.H147Y|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Missense_Mutation_p.H154Y	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	154	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						CCACGGGGATGAACCCAGCCA	0.687													33	46					0	0	0	0	A	62384617	A	A	62384617	3	1	204	1	0	0	0	0	1	0	0	0	1257	1290	45	2	559	2	B3GAT3	11	62384617	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	3492276	62384617	72621899	132	37404											
TM7SF2	7108	broad.mit.edu	37	chr11	64883456	64883456	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgagcggcagtgcctgcaGaagtacggcctggcctggca	8	6	16	11	2	0	2	0	1	0	1	0	3	0	2	3	4	4	4	3	4	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:64883456G>A	uc001oct.2	+	10	1335	c.1188G>A	c.(1186-1188)CAG>CAA	p.Q396Q	TM7SF2_uc010rny.1_Silent_p.Q280Q|TM7SF2_uc001ocu.2_Silent_p.Q369Q|TM7SF2_uc001ocv.2_Silent_p.Q417Q|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	396					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						AGTGCCTGCAGAAGTACGGCC	0.632													21	32					0	0	0	0	A	64883456	A	A	64883456	2	1	204	1	0	0	0	0	0	0	0	1	16040	933	33	2		2	TM7SF2	11	64883456	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	2498839	64883456	70123060	133	37405											
RAB1B	81876	broad.mit.edu	37	chr11	66039643	66039643	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaggatgacacgtacacaGagagctacatcagcaccatc	14	7	8	12	1	2	2	2	1	0	1	3	4	2	3	1	1	4	3	1	1	2	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:66039643G>C	uc001ohf.2	+	3	198	c.103G>C	c.(103-105)GAG>CAG	p.E35Q	uc001ohg.1_RNA	NM_030981	NP_112243	Q9H0U4	RAB1B_HUMAN	RAB1B, member RAS oncogene family	35					protein transport|small GTPase mediated signal transduction	Golgi apparatus|membrane	GTP binding|protein binding				0						CACGTACACAGAGAGCTACAT	0.527													74	150					0	0	0	0	C	66039643	C	C	66039643	3	2	204	1	0	0	0	0	1	0	0	0	12971	943	33	2	113	2	RAB1B	11	66039643	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	1156187	66039643	68966873	134	37406											
TCIRG1	10312	broad.mit.edu	37	chr11	67816400	67816400	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaactccttcaagatgaagAtgtccgtcatcctgggcgtc	9	11	9	12	2	3	3	3	1	0	2	7	3	6	3	3	1	1	0	3	1	3	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:67816400A>T	uc001one.2	+	14	1717	c.1609A>T	c.(1609-1611)ATG>TTG	p.M537L	TCIRG1_uc001ong.2_Missense_Mutation_p.M321L|TCIRG1_uc001onh.2_Missense_Mutation_p.M239L|TCIRG1_uc001oni.2_Missense_Mutation_p.M41L|TCIRG1_uc009ysd.2_5'Flank	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	537	Lumenal (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						CAAGATGAAGATGTCCGTCAT	0.632													62	86					0	0	0	0	T	67816400	T	T	67816400	3	4	204	1	0	0	0	0	1	0	0	0	15769	333	12	5	1659	5	TCIRG1	11	67816400	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	1776757	67816400	67190116	135	37407											
NAALAD2	10003	broad.mit.edu	37	chr11	89902099	89902099	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actttgcttcaactacaggaGaatgtcaaaatactccagga	15	10	7	9	0	2	1	2	0	0	1	3	3	3	2	1	2	4	1	1	2	6	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:89902099G>C	uc001pdf.3	+	12	1390	c.1281G>C	c.(1279-1281)GAG>GAC	p.E427D	NAALAD2_uc009yvx.2_Missense_Mutation_p.E394D|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	427	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				AACTACAGGAGAATGTCAAAA	0.303													12	42					0	0	0	0	C	89902099	C	C	89902099	3	2	204	1	0	0	0	0	1	0	0	0	10181	933	33	2	1327	2	NAALAD2	11	89902099	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	22085699	89902099	45104417	136	37408											
CNTN5	53942	broad.mit.edu	37	chr11	100211833	100211833	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttattttgcagctcctagtCaagcacctagcaacctcagg	10	12	7	12	0	2	0	2	0	0	0	3	0	3	0	3	1	5	4	3	1	5	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:100211833C>G	uc001pga.2	+	23	3265	c.2926C>G	c.(2926-2928)CAA>GAA	p.Q976E	CNTN5_uc001pgb.2_Missense_Mutation_p.Q902E|CNTN5_uc010ruk.1_Missense_Mutation_p.Q247E	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	976	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGCTCCTAGTCAAGCACCTAG	0.428													4	110					0	0	0	0	G	100211833	G	G	100211833	3	3	204	1	0	0	0	0	1	0	0	0	3659	827	29	2	3008	2	CNTN5	11	100211833	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	10309734	100211833	34794683	137	37409											
DYNC2H1	79659	broad.mit.edu	37	chr11	102993566	102993566	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttttaaggtagatgatactAtcaagattgcagaggctctt	12	15	9	5	0	2	4	1	1	1	3	2	4	2	4	0	2	2	3	0	2	5	8			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:102993566A>C	uc001pho.2	+	11	1642	c.1498A>C	c.(1498-1500)ATC>CTC	p.I500L	DYNC2H1_uc001phn.1_Missense_Mutation_p.I500L|DYNC2H1_uc009yxe.1_Missense_Mutation_p.I500L	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	500	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AGATGATACTATCAAGATTGC	0.358													15	25					0	0	0	0	C	102993566	C	C	102993566	3	2	204	1	0	0	0	0	1	0	0	0	4868	449	16	5	1540	5	DYNC2H1	11	102993566	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	2781733	102993566	32012950	138	37410											
BSX	390259	broad.mit.edu	37	chr11	122850009	122850009	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggccgtggccagctccactCgttctggcgtggacaggtag	5	8	16	12	3	1	0	0	0	1	0	3	1	2	1	3	5	1	3	3	5	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr11:122850009C>T	uc010rzs.1	-	2	419	c.419G>A	c.(418-420)CGA>CAA	p.R140Q		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	140	Homeobox.										0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		CAGCTCCACTCGTTCTGGCGT	0.637													42	97					0	0	0	0	T	122850009	T	T	122850009	3	4	204	1	0	0	0	0	1	0	0	0	1540	884	31	1	289	1	BSX	11	122850009	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	19856443	122850009	12156507	139	37411											
FGF23	8074	broad.mit.edu	37	chr12	4479837	4479837	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatgcctggcaggaaggctCtcttcgcccggcccagactg	6	8	12	15	2	2	1	1	0	1	1	4	2	2	2	3	4	1	2	3	4	1	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:4479837C>G	uc001qmq.1	-	3	574	c.428G>C	c.(427-429)AGA>ACA	p.R143T		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	143					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CAGGAAGGCTCTCTTCGCCCG	0.597													68	110					0	0	0	0	G	4479837	G	G	4479837	3	3	204	1	0	0	0	0	1	0	0	0	5884	913	32	2	331	2	FGF23	12	4479837	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08		4479837	129372058	140	37412											
GDF3	9573	broad.mit.edu	37	chr12	7842556	7842556	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tattgtcctggtagagcatgGaaatgggagacagcttggtg	10	11	15	5	0	0	2	0	0	0	2	1	4	1	3	1	4	2	3	1	4	3	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:7842556G>A	uc001qte.2	-	2	1049	c.1013C>T	c.(1012-1014)TCC>TTC	p.S338F		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	338					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						GTAGAGCATGGAAATGGGAGA	0.478													30	59					0	0	0	0	A	7842556	A	A	7842556	3	1	204	1	0	0	0	0	1	0	0	0	6352	1174	41	2	85	2	GDF3	12	7842556	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	3362719	7842556	126009339	141	37413											
TMPRSS12	283471	broad.mit.edu	37	chr12	51281127	51281127	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aattaccagttacggacatgGctgtggtcgaagaggttttc	10	12	12	7	2	0	1	0	0	0	1	2	3	0	2	1	4	2	3	1	4	4	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:51281127G>A	uc001rwx.3	+	5	925	c.878G>A	c.(877-879)GGC>GAC	p.G293D	TMPRSS12_uc001rwy.2_3'UTR	NM_182559	NP_872365	Q86WS5	TMPSC_HUMAN	transmembrane protease, serine 12 precursor	293	Peptidase S1.|Extracellular (Potential).				proteolysis	integral to membrane	serine-type endopeptidase activity				0						TACGGACATGGCTGTGGTCGA	0.433													53	73					0	0	0	0	A	51281127	A	A	51281127	3	1	204	1	0	0	0	0	1	0	0	0	16310	1203	42	4	896	4	TMPRSS12	12	51281127	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	43438571	51281127	82570768	142	37414											
KRT76	51350	broad.mit.edu	37	chr12	53164843	53164843	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctccacatccagggccagcTtgacgttcatcagctcctgg	7	10	9	15	1	3	1	2	1	1	0	6	1	5	1	4	2	2	3	4	2	0	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:53164843T>G	uc001sax.2	-	7	1478	c.1424A>C	c.(1423-1425)AAG>ACG	p.K475T		NM_015848	NP_056932	Q01546	K22O_HUMAN	keratin 76	475	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|skin(1)	2						CAGGGCCAGCTTGACGTTCAT	0.572													9	116					0	0	0	0	G	53164843	G	G	53164843	3	3	204	1	0	0	0	0	1	0	0	0	8528	1609	56	5	504	5	KRT76	12	53164843	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	1883716	53164843	80687052	143	37415											
OR6C75	390323	broad.mit.edu	37	chr12	55759093	55759093	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttcggaacttctcattcCtggaaatttcattcacgtct	8	16	5	12	2	4	0	3	0	2	0	8	2	6	2	2	2	1	0	2	2	2	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:55759093C>T	uc010spk.1	+	1	199	c.199C>T	c.(199-201)CTG>TTG	p.L67L		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						CTTCTCATTCCTGGAAATTTC	0.443													81	119					0	0	0	0	T	55759093	T	T	55759093	2	4	204	1	0	0	0	0	0	0	0	1	11253	680	24	4		4	OR6C75	12	55759093	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	2594250	55759093	78092802	144	37416											
LRP1	4035	broad.mit.edu	37	chr12	57594938	57594938	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggatgagagggactgccgTgagtgtcagaggtggtggtg	8	8	21	4	1	1	3	1	2	0	2	1	7	1	5	1	5	1	0	1	5	0	0	rs111522273		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:57594938T>C	uc001snd.2	+	65	10811	c.10345_splice	c.e65+2	p.P3449_splice		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1						aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGGACTGCCGTGAGTGTCAGA	0.567													45	84					0	0	0	0	C	57594938	C	C	57594938	5	2	204	1	0	0	0	0	0	0	1	0	9001	1710	59	5	10605	5	LRP1	12	57594938	Splice_Site	SNP	T	TCGA-CV-6948-01A-11D-1912-08	1835845	57594938	76256957	145	37417											
HELB	92797	broad.mit.edu	37	chr12	66725387	66725387	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcatccaaaagaacctgtGgtgtgaatgatgatgaaagt	15	9	12	5	0	0	5	0	4	0	1	1	6	1	5	2	1	2	1	2	1	5	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:66725387G>C	uc001sti.2	+	12	3152	c.3124G>C	c.(3124-3126)GGT>CGT	p.G1042R	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	1042					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		AAGAACCTGTGGTGTGAATGA	0.388													5	160					0	0	0	0	C	66725387	C	C	66725387	3	2	204	1	0	0	0	0	1	0	0	0	7084	1348	47	4	3170	4	HELB	12	66725387	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	9130449	66725387	67126508	146	37418											
IL22	50616	broad.mit.edu	37	chr12	68645319	68645319	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactgtgtccttcagcttttGcacattcctctggatatgca	7	15	7	12	0	2	0	1	0	1	0	4	1	4	1	2	1	3	3	2	1	1	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:68645319G>T	uc001sty.1	-	4	489	c.436C>A	c.(436-438)CAA>AAA	p.Q146K	IL22_uc010stb.1_Missense_Mutation_p.Q146K	NM_020525	NP_065386	Q9GZX6	IL22_HUMAN	interleukin 22 precursor	146					acute-phase response	extracellular space	cytokine activity|interleukin-22 receptor binding				0		Myeloproliferative disorder(1001;0.0255)	Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;5.06e-05)|BRCA - Breast invasive adenocarcinoma(357;0.00104)		TTCAGCTTTTGCACATTCCTC	0.363													23	134					3.73808e-20	5.08443e-20	1	0	T	68645319	T	T	68645319	3	4	204	1	0	0	0	0	1	0	0	0	7711	1328	46	4	111	4	IL22	12	68645319	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	1919932	68645319	65206576	147	37419											
MDM1	56890	broad.mit.edu	37	chr12	68719244	68719244	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attggctgcaaaagctggagCagtttctttagaagtcttcc	10	13	10	8	0	2	1	0	0	2	1	3	2	3	2	1	2	3	5	1	2	4	5	rs138314442		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:68719244C>A	uc001stz.2	-	4	746	c.610G>T	c.(610-612)GCT>TCT	p.A204S	MDM1_uc010stc.1_Intron|MDM1_uc009zqv.1_5'UTR|MDM1_uc001sua.3_3'UTR|MDM1_uc010std.1_3'UTR	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	204						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		AAAGCTGGAGCAGTTTCTTTA	0.348													103	380					2.98183e-41	4.1981e-41	1	0	A	68719244	A	A	68719244	3	1	204	1	0	0	0	0	1	0	0	0	9465	710	25	4	1578	4	MDM1	12	68719244	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	73925	68719244	65132651	148	37420											
GALNT4	8693	broad.mit.edu	37	chr12	89917406	89917406	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacagtcctccagccatggtAggtgatctgatggggtcaat	10	10	12	9	0	2	2	1	2	1	0	4	2	4	2	3	4	2	1	3	4	3	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:89917406A>T	uc001tbd.2	-	1	1130	c.921T>A	c.(919-921)CCT>CCA	p.P307P	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Silent_p.P304P|GALNT4_uc010suo.1_5'UTR	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	307	Catalytic subdomain B.|Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						CAGCCATGGTAGGTGATCTGA	0.473													7	79					0	0	0	0	T	89917406	T	T	89917406	2	4	204	1	0	0	0	0	0	0	0	1	6250	407	15	5		5	GALNT4	12	89917406	Silent	SNP	A	TCGA-CV-6948-01A-11D-1912-08	21198162	89917406	43934489	149	37421											
STAB2	55576	broad.mit.edu	37	chr12	104118864	104118864	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttacctgccgcggcagcAtttatcaggtaacgcgagac	10	9	11	11	4	1	1	1	0	0	1	1	3	1	1	2	2	4	3	2	2	3	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:104118864A>T	uc001tjw.2	+	45	4981	c.4795A>T	c.(4795-4797)ATT>TTT	p.I1599F	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1599	Extracellular (Potential).|FAS1 5.			IY -> HE (in Ref. 7; AAF82398).	angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCGCGGCAGCATTTATCAGGT	0.438													67	16					0	0	0	0	T	104118864	T	T	104118864	3	4	204	1	0	0	0	0	1	0	0	0	15304	217	8	5	4973	5	STAB2	12	104118864	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	14201458	104118864	29733031	150	37422											
GLT8D2	83468	broad.mit.edu	37	chr12	104390557	104390557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcctgagcagagggcaaatCgcagtcatctgagaaagccg	12	6	13	10	2	2	3	1	2	1	2	4	4	3	3	2	1	2	3	2	1	2	0	rs7133444		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:104390557C>T	uc001tkh.1	-	8	962	c.556G>A	c.(556-558)GAT>AAT	p.D186N	GLT8D2_uc001tki.1_Missense_Mutation_p.D186N	NM_031302	NP_112592	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	186	Lumenal (Potential).					integral to membrane	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2						GAGGGCAAATCGCAGTCATCT	0.502													59	19					0	0	0	0	T	104390557	T	T	104390557	3	4	204	1	0	0	0	0	1	0	0	0	6507	884	31	1	509	1	GLT8D2	12	104390557	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	271693	104390557	29461338	151	37423											
C12orf51	283450	broad.mit.edu	37	chr12	112665943	112665943	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actgccatcacaggagctgaCccatctcctgttgcaggaag	10	8	10	13	0	2	1	1	1	1	0	3	3	2	3	3	2	3	3	3	2	1	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr12:112665943C>T	uc009zwc.2	-	36	5556	c.5538G>A	c.(5536-5538)GGG>GGA	p.G1846G	C12orf51_uc001ttr.1_Silent_p.G21G	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CAGGAGCTGACCCATCTCCTG	0.517													43	22					0	0	0	0	T	112665943	T	T	112665943	2	4	204	1	0	0	0	0	0	0	0	1	1702	494	18	4		4	C12orf51	12	112665943	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	8275386	112665943	21185952	152	37424											
CDK8	1024	broad.mit.edu	37	chr13	26975692	26975692	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtcacacacagggacccccGttgaagaaagtgagagttgt	13	7	12	9	1	1	3	1	2	0	2	1	5	1	4	2	1	0	2	2	1	2	2	rs138501276		TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr13:26975692G>A	uc001uqr.1	+	12	1226	c.1200G>A	c.(1198-1200)CCG>CCA	p.P400P	CDK8_uc001uqs.1_Silent_p.P399P|CDK8_uc001uqt.1_Silent_p.P227P	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGGGACCCCCGTTGAAGAAAG	0.473													7	47					0	0	0	0	A	26975692	A	A	26975692	2	1	204	1	0	0	0	0	0	0	0	1	3165	1132	40	1		1	CDK8	13	26975692	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08		26975692	88194186	153	37425											
MYCBP2	23077	broad.mit.edu	37	chr13	77671556	77671556	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggtatggatgtgactcccCacacagttcacagatggtat	10	10	11	10	1	1	2	1	1	0	1	2	3	2	3	2	3	0	3	2	3	2	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr13:77671556C>G	uc001vkf.2	-	57	9710	c.9619G>C	c.(9619-9621)GGG>CGG	p.G3207R	MYCBP2_uc010aev.2_Missense_Mutation_p.G2611R|MYCBP2_uc001vkg.1_Missense_Mutation_p.G730R	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGTGACTCCCCACACAGTTCA	0.423													14	29					0	0	0	0	G	77671556	G	G	77671556	3	3	204	1	0	0	0	0	1	0	0	0	10071	594	21	4	4415	4	MYCBP2	13	77671556	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	50695864	77671556	37498322	154	37426											
SLITRK5	26050	broad.mit.edu	37	chr13	88327892	88327892	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccctccccgtttcccaatCtaccacctcttgttgtccgg	5	12	6	18	2	2	0	0	0	2	0	5	0	5	0	7	1	2	2	7	1	2	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr13:88327892C>T	uc001vln.2	+	2	468	c.249C>T	c.(247-249)ATC>ATT	p.I83I	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	83	LRR 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GTTTCCCAATCTACCACCTCT	0.453													84	138					0	0	0	0	T	88327892	T	T	88327892	2	4	204	1	0	0	0	0	0	0	0	1	14810	903	32	2		2	SLITRK5	13	88327892	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	10656336	88327892	26841986	155	37427											
SLITRK5	26050	broad.mit.edu	37	chr13	88328028	88328029	+	Frame_Shift_Ins	INS	-	G	G																															cggggctttccatgggctacINSggggtttgaggagattgcat																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr13:88328028_88328029insG	uc001vln.2	+	2	604_605	c.385_386insG	c.(385-387)CGGfs	p.R129fs	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	129	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCATGGGCTACGGGGTTTGAGG	0.45													---	---	---								G	88328029	G	G	88328028	7	5	204	1	0	1	1	0	0	0	0	0	14810	527	19	0	387	0	SLITRK5	13	88328028	Frame_Shift_Ins	INS	-	TCGA-CV-6948-01A-11D-1912-08	136	88328028	26841850	156	37428											
F10	2159	broad.mit.edu	37	chr13	113777199	113777199	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccactgcacctcgtcctgctCagtgcctccctggctggcct	3	10	9	19	1	1	0	1	0	0	0	4	0	3	0	6	2	3	3	6	2	0	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr13:113777199C>T	uc001vsx.2	+	1	87	c.30C>T	c.(28-30)CTC>CTT	p.L10L	F10_uc010agq.1_RNA|F10_uc001vsy.2_Silent_p.L10L|F10_uc001vsz.2_Silent_p.L10L	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	10					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCGTCCTGCTCAGTGCCTCCC	0.672													12	25					0	0	0	0	T	113777199	T	T	113777199	2	4	204	1	0	0	0	0	0	0	0	1	5361	813	29	2		2	F10	13	113777199	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	25449171	113777199	1392679	157	37429											
AP1G2	8906	broad.mit.edu	37	chr14	24034829	24034829	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccccacctgcaggaaggggtCgctgactccagatatgctgt	8	8	12	13	1	0	2	0	1	0	1	2	3	1	3	4	3	2	3	4	3	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:24034829C>T	uc001wkl.2	-	7	1064	c.727G>A	c.(727-729)GAC>AAC	p.D243N	AP1G2_uc001wkj.2_5'UTR|AP1G2_uc001wkk.3_Missense_Mutation_p.D171N|AP1G2_uc001wkn.2_5'UTR|uc001wko.1_RNA|AP1G2_uc001wkp.1_5'Flank|AP1G2_uc010tnp.1_Missense_Mutation_p.D243N|AP1G2_uc010aks.2_Missense_Mutation_p.D171N|AP1G2_uc010akt.2_Missense_Mutation_p.D171N|AP1G2_uc010tnq.1_RNA	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	243					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		AGGAAGGGGTCGCTGACTCCA	0.557													16	31					0	0	0	0	T	24034829	T	T	24034829	3	4	204	1	0	0	0	0	1	0	0	0	733	884	31	1	1694	1	AP1G2	14	24034829	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08		24034829	83314711	158	37430											
NYNRIN	57523	broad.mit.edu	37	chr14	24884134	24884134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcgacctcctgccaggggCagcttctccctacctgggca	6	8	10	17	1	1	0	0	0	1	0	4	1	2	0	5	3	3	3	5	3	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:24884134C>T	uc001wpf.3	+	9	3497	c.3179C>T	c.(3178-3180)GCA>GTA	p.A1060V		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1060					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						CTGCCAGGGGCAGCTTCTCCC	0.647													9	121					0	0	0	0	T	24884134	T	T	24884134	3	4	204	1	0	0	0	0	1	0	0	0	10850	710	25	4	3209	4	NYNRIN	14	24884134	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	849305	24884134	82465406	159	37431											
KLHL28	54813	broad.mit.edu	37	chr14	45414307	45414307	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagcacagcgaggtcgtgtCatcaagactgtctgatgaga	11	8	14	8	2	3	3	2	2	1	2	4	6	3	4	0	2	2	1	0	2	1	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:45414307C>T	uc001wvq.2	-	2	1071	c.825G>A	c.(823-825)ATG>ATA	p.M275I	KLHL28_uc001wvr.2_Missense_Mutation_p.M275I|KLHL28_uc001wvt.3_Missense_Mutation_p.M275I	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	275										ovary(1)	1						GAGGTCGTGTCATCAAGACTG	0.418													50	65					0	0	0	0	T	45414307	T	T	45414307	3	4	204	1	0	0	0	0	1	0	0	0	8421	826	29	2	906	2	KLHL28	14	45414307	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	20530173	45414307	61935233	160	37432											
SOS2	6655	broad.mit.edu	37	chr14	50616839	50616839	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatatgccattcaattggTggaggtggactttcaaaggt	10	13	12	6	0	2	1	2	1	0	0	2	3	2	3	1	5	1	0	1	5	3	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:50616839T>A	uc001wxs.3	-	14	2369	c.2271A>T	c.(2269-2271)CCA>CCT	p.P757P	SOS2_uc010tql.1_Silent_p.P724P|SOS2_uc010tqm.1_RNA	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	757	Poly-Pro.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					ATTCAATTGGTGGAGGTGGAC	0.408													50	94					0	0	0	0	A	50616839	A	A	50616839	2	1	204	1	0	0	0	0	0	0	0	1	15001	1683	59	5		5	SOS2	14	50616839	Silent	SNP	T	TCGA-CV-6948-01A-11D-1912-08	5202532	50616839	56732701	161	37433											
SYNE2	23224	broad.mit.edu	37	chr14	64518544	64518544	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgaataaggtacaggacaCtgagatttctctgcaacagc	14	9	9	9	0	1	2	0	2	1	1	2	4	1	3	0	2	4	2	0	2	4	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:64518544C>G	uc001xgm.2	+	48	8143	c.7913C>G	c.(7912-7914)ACT>AGT	p.T2638S	SYNE2_uc001xgl.2_Missense_Mutation_p.T2638S	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2638	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GTACAGGACACTGAGATTTCT	0.448													14	99					0	0	0	0	G	64518544	G	G	64518544	3	3	204	1	0	0	0	0	1	0	0	0	15512	565	20	4	8099	4	SYNE2	14	64518544	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	13901705	64518544	42830996	162	37434											
MTHFD1	4522	broad.mit.edu	37	chr14	64891551	64891551	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccaaatgggagaaaagttGtgggtgatgtggcatacgac	14	8	14	5	1	0	2	0	1	0	1	0	4	0	2	1	3	2	2	1	3	5	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:64891551G>T	uc001xhb.2	+	9	1144	c.757G>T	c.(757-759)GTG>TTG	p.V253L	MTHFD1_uc010aqe.2_Missense_Mutation_p.V289L|MTHFD1_uc010aqf.2_Missense_Mutation_p.V309L	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	253	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GAGAAAAGTTGTGGGTGATGT	0.488													4	38					1.23904e-05	1.52974e-05	1	0	T	64891551	T	T	64891551	3	4	204	1	0	0	0	0	1	0	0	0	9980	1377	48	4	791	4	MTHFD1	14	64891551	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	373007	64891551	42457989	163	37435											
ARG2	384	broad.mit.edu	37	chr14	68108986	68108986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaacctgatagtgaatccaCgctcagtgggtcttgccaac	11	9	9	12	1	2	2	1	2	1	0	3	2	3	2	3	1	3	1	3	1	4	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:68108986C>T	uc001xjs.2	+	3	384	c.268C>T	c.(268-270)CGC>TGC	p.R90C		NM_001172	NP_001163	P78540	ARGI2_HUMAN	arginase 2 precursor	90					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding				0				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	AGTGAATCCACGCTCAGTGGG	0.507													24	31					0	0	0	0	T	68108986	T	T	68108986	3	4	204	1	0	0	0	0	1	0	0	0	858	536	19	1	278	1	ARG2	14	68108986	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	3217435	68108986	39240554	164	37436											
TMEM90A	646658	broad.mit.edu	37	chr14	74874373	74874373	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgctggccaggcggaagtcCcctttggagatggccttgct	5	10	15	11	1	0	1	0	0	0	1	1	3	1	2	4	5	2	2	4	5	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:74874373C>T	uc001xpx.2	-	4	830	c.582G>A	c.(580-582)GGG>GGA	p.G194G		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	194					response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		GGCGGAAGTCCCCTTTGGAGA	0.662													33	69					0	0	0	0	T	74874373	T	T	74874373	2	4	204	1	0	0	0	0	0	0	0	1	16284	610	22	4		4	TMEM90A	14	74874373	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	6765387	74874373	32475167	165	37437											
CCDC88C	440193	broad.mit.edu	37	chr14	91787565	91787565	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcccctggatggtgctctGgaggctctgattctccttct	4	13	11	13	0	4	1	0	1	4	0	5	3	4	3	3	4	2	2	3	4	0	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:91787565G>A	uc010aty.2	-	13	1525	c.1426C>T	c.(1426-1428)CAG>TAG	p.Q476*		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	476	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				ATGGTGCTCTGGAGGCTCTGA	0.587													8	14					0	0	0	0	A	91787565	A	A	91787565	4	1	204	1	0	0	0	0	0	1	0	0	2878	1357	47	4	4732	4	CCDC88C	14	91787565	Nonsense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	16913192	91787565	15561975	166	37438											
PPP4R4	57718	broad.mit.edu	37	chr14	94722876	94722876	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatctacttcagcagttaGaaatgtgtgtgaggaaactc	13	11	10	7	0	2	2	1	1	1	1	3	3	2	3	0	1	4	3	0	1	4	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:94722876G>T	uc001ycs.1	+	17	2099	c.1945G>T	c.(1945-1947)GAA>TAA	p.E649*		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	649						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TCAGCAGTTAGAAATGTGTGT	0.348													5	26					0.000602214	0.000721309	1	0	T	94722876	T	T	94722876	4	4	204	1	0	0	0	0	0	1	0	0	12465	943	33	2	2084	2	PPP4R4	14	94722876	Nonsense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	2935311	94722876	12626664	167	37439											
HHIPL1	84439	broad.mit.edu	37	chr14	100125954	100125954	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcctcgggcactggccgCgggcgcctcttctgcggcga	2	7	14	18	6	2	0	0	0	2	0	4	1	3	0	4	4	1	1	4	4	0	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:100125954C>T	uc010avs.2	+	4	1301	c.1236C>T	c.(1234-1236)CGC>CGT	p.R412R	HHIPL1_uc001ygl.1_Silent_p.R412R	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	412					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				GCACTGGCCGCGGGCGCCTCT	0.726													6	4					0	0	0	0	T	100125954	T	T	100125954	2	4	204	1	0	0	0	0	0	0	0	1	7132	755	27	1		1	HHIPL1	14	100125954	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	5403078	100125954	7223586	168	37440											
AHNAK2	113146	broad.mit.edu	37	chr14	105421961	105421961	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagcgtcacctctgttgcctCctggacagcctggagcagaa	8	8	11	14	1	2	1	1	0	1	1	3	3	3	3	4	2	4	2	4	2	1	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr14:105421961C>T	uc010axc.1	-	5	445	c.325G>A	c.(325-327)GAG>AAG	p.E109K	AHNAK2_uc001ypx.2_Missense_Mutation_p.E9K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	109						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTGTTGCCTCCTGGACAGCC	0.602													30	48					0	0	0	0	T	105421961	T	T	105421961	3	4	204	1	0	0	0	0	1	0	0	0	415	864	30	2	17074	2	AHNAK2	14	105421961	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	5296007	105421961	1927579	169	37441											
ATP8B4	79895	broad.mit.edu	37	chr15	50264849	50264849	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgagggtacccgttttgtcGgagaaaatgtactcaatctg	10	12	12	7	2	2	2	1	1	1	1	3	3	2	2	1	2	2	3	1	2	5	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr15:50264849G>T	uc001zxu.2	-	13	1315	c.1173C>A	c.(1171-1173)TCC>TCA	p.S391S	ATP8B4_uc010ber.2_Silent_p.S264S|ATP8B4_uc010ufd.1_Silent_p.S264S|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	391	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CCGTTTTGTCGGAGAAAATGT	0.433													20	3					3.7963e-18	5.14183e-18	1	0	T	50264849	T	T	50264849	2	4	204	1	0	0	0	0	0	0	0	1	1199	1103	39	3		3	ATP8B4	15	50264849	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08		50264849	52266543	170	37442											
USP8	9101	broad.mit.edu	37	chr15	50769168	50769168	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actccacccccacgacgccaGaatgaagaggtgtctatctc	11	7	8	15	2	2	3	0	1	2	2	4	4	3	3	4	1	0	0	4	1	3	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr15:50769168G>A	uc001zym.3	+	10	1472	c.972G>A	c.(970-972)CAG>CAA	p.Q324Q	USP8_uc001zyk.1_Missense_Mutation_p.R24K|USP8_uc001zyl.3_Silent_p.Q324Q|USP8_uc001zyn.3_Silent_p.Q324Q|USP8_uc010ufh.1_Silent_p.Q247Q|USP8_uc010bev.1_Intron	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	324					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CACGACGCCAGAATGAAGAGG	0.393													26	14					0	0	0	0	A	50769168	A	A	50769168	2	1	204	1	0	0	0	0	0	0	0	1	17157	933	33	2		2	USP8	15	50769168	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	504319	50769168	51762224	171	37443											
CSPG4	1464	broad.mit.edu	37	chr15	75982451	75982451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgagaaggagactgccccGtggctccaggtagctgagga	9	5	15	12	2	0	3	0	1	0	2	1	6	1	4	4	4	2	3	4	4	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr15:75982451G>A	uc002baw.2	-	3	1048	c.955C>T	c.(955-957)CGG>TGG	p.R319W		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	319	Extracellular (Potential).|Neurite growth inhibition (By similarity).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						AGACTGCCCCGTGGCTCCAGG	0.617													12	7					0	0	0	0	A	75982451	A	A	75982451	3	1	204	1	0	0	0	0	1	0	0	0	3977	1144	40	1	6045	1	CSPG4	15	75982451	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	25213283	75982451	26548941	172	37444											
HDGFRP3	50810	broad.mit.edu	37	chr15	83820108	83820108	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatttccgggactgtttagaGgatttctaaatgtttagaca	11	15	10	5	1	1	2	0	0	1	2	2	5	2	4	1	2	0	2	1	2	4	7			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr15:83820108G>A	uc002bjs.1	-	5	620	c.465C>T	c.(463-465)TCC>TCT	p.S155S		NM_016073	NP_057157	Q9Y3E1	HDGR3_HUMAN	hepatoma-derived growth factor, related protein	155					cell proliferation	nucleus	growth factor activity				0						ACTGTTTAGAGGATTTCTAAA	0.393													17	31					0	0	0	0	A	83820108	A	A	83820108	2	1	204	1	0	0	0	0	0	0	0	1	7060	987	35	4		4	HDGFRP3	15	83820108	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	7837657	83820108	18711284	173	37445											
CACNA1H	8912	broad.mit.edu	37	chr16	1245997	1245997	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaccgtgcgggtgctgcggcCcctccgcgccatcaaccgcg	4	5	14	18	7	1	0	1	0	0	0	2	1	2	0	6	2	4	1	6	2	1	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:1245997C>T	uc002cks.2	+	5	865	c.617C>T	c.(616-618)CCC>CTC	p.P206L	CACNA1H_uc002ckt.2_Missense_Mutation_p.P206L	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	206	Helical; Name=S4 of repeat I; (Potential).|I.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GTGCTGCGGCCCCTCCGCGCC	0.657													41	56					0	0	0	0	T	1245997	T	T	1245997	3	4	204	1	0	0	0	0	1	0	0	0	2557	623	22	4	631	4	CACNA1H	16	1245997	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08		1245997	89108756	174	37446											
RAB26	25837	broad.mit.edu	37	chr16	2201695	2201695	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccagtgcctgtcgctgcaGatgtgggacacagctggtca	8	8	14	11	1	1	1	1	0	0	1	2	3	1	2	2	2	3	3	2	2	0	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:2201695G>T	uc002cou.2	+	4	483	c.349_splice	c.e4-1	p.M117_splice	RAB26_uc010bsf.2_Splice_Site_p.M51_splice	NM_014353	NP_055168	Q9ULW5	RAB26_HUMAN	RAB26, member RAS oncogene family						exocrine system development|protein transport|regulation of exocytosis|small GTPase mediated signal transduction	intrinsic to plasma membrane	GTP binding|protein binding				0						TGTCGCTGCAGATGTGGGACA	0.622													16	31					7.05477e-17	9.43575e-17	1	0	T	2201695	T	T	2201695	5	4	204	1	0	0	0	0	0	0	1	0	12978	956	33	2	362	2	RAB26	16	2201695	Splice_Site	SNP	G	TCGA-CV-6948-01A-11D-1912-08	955698	2201695	88153058	175	37447											
RAB26	25837	broad.mit.edu	37	chr16	2203334	2203334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgcagggagttgaagcagcGctccatgaaggctcccagcg	9	5	14	13	3	0	2	0	2	0	0	2	3	2	3	3	2	3	5	3	2	2	1	rs149402189	byFrequency	TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:2203334G>A	uc002cou.2	+	9	817	c.683G>A	c.(682-684)CGC>CAC	p.R228H	RAB26_uc010bsf.2_Missense_Mutation_p.R162H|TRAF7_uc002cow.2_5'Flank	NM_014353	NP_055168	Q9ULW5	RAB26_HUMAN	RAB26, member RAS oncogene family	228					exocrine system development|protein transport|regulation of exocytosis|small GTPase mediated signal transduction	intrinsic to plasma membrane	GTP binding|protein binding				0						TTGAAGCAGCGCTCCATGAAG	0.642													26	48					0	0	0	0	A	2203334	A	A	2203334	3	1	204	1	0	0	0	0	1	0	0	0	12978	1087	38	1	717	1	RAB26	16	2203334	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	1639	2203334	88151419	176	37448											
USP7	7874	broad.mit.edu	37	chr16	8990890	8990890	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctttctccccaagctccaCggcctttttacattcttcta	6	16	4	15	1	3	0	0	0	3	0	5	0	4	0	4	1	3	2	4	1	3	7			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:8990890C>G	uc002czl.2	-	26	2984	c.2785G>C	c.(2785-2787)GTG>CTG	p.V929L	USP7_uc010uyk.1_Missense_Mutation_p.V830L|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.V830L|USP7_uc002czk.2_Missense_Mutation_p.V913L	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	929					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						CCAAGCTCCACGGCCTTTTTA	0.438													13	251					0	0	0	0	G	8990890	G	G	8990890	3	3	204	1	0	0	0	0	1	0	0	0	17156	536	19	3	547	3	USP7	16	8990890	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	6787556	8990890	81363863	177	37449											
CIITA	4261	broad.mit.edu	37	chr16	11004076	11004076	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctcggaagacacagctgggGagctccctgctgttcgggac	7	7	14	13	2	0	1	0	0	0	1	3	4	1	4	2	4	3	4	2	4	1	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:11004076G>T	uc002dai.3	+	13	2981	c.2848G>T	c.(2848-2850)GAG>TAG	p.E950*	CIITA_uc002daj.3_Nonsense_Mutation_p.E951*|CIITA_uc002dak.3_Nonsense_Mutation_p.E366*|CIITA_uc010bup.1_Silent_p.G346G	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	950			Missing (in BLS2).		interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CACAGCTGGGGAGCTCCCTGC	0.557			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								11	22					0.00010058	0.000121835	1	0	T	11004076	T	T	11004076	4	4	204	1	0	0	0	0	0	1	0	0	3443	1175	41	2	2898	2	CIITA	16	11004076	Nonsense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	2013186	11004076	79350677	178	37450											
MYH11	4629	broad.mit.edu	37	chr16	15797863	15797863	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgcttattcactggccttGgttccattgaagtctgcgtc	5	16	10	10	1	2	1	1	1	1	0	4	1	3	1	2	2	2	3	2	2	2	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:15797863G>A	uc002ddy.2	-	41	6011	c.5904C>T	c.(5902-5904)ACC>ACT	p.T1968T	MYH11_uc002ddv.2_3'UTR|MYH11_uc002ddw.2_3'UTR|MYH11_uc002ddx.2_Silent_p.T1975T|MYH11_uc010bvg.2_3'UTR|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1968	Carboxyl-terminal.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CACTGGCCTTGGTTCCATTGA	0.428			T	CBFB	AML								111	153					0	0	0	0	A	15797863	A	A	15797863	2	1	204	1	0	0	0	0	0	0	0	1	10084	1335	47	4		4	MYH11	16	15797863	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	4793787	15797863	74556890	179	37451											
ZNF768	79724	broad.mit.edu	37	chr16	30536326	30536326	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctggctatagcacttgcCgcactcggtgcagctgtagg	6	11	13	11	2	1	0	0	0	1	0	2	0	1	0	1	3	4	7	1	3	3	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:30536326C>A	uc002dyk.3	-	2	1311	c.1135G>T	c.(1135-1137)GGC>TGC	p.G379C	ZNF768_uc010vex.1_Missense_Mutation_p.G348C|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.G348C	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	379	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						TAGCACTTGCCGCACTCGGTG	0.637													23	20					2.41591e-17	3.2448e-17	1	0	A	30536326	A	A	30536326	3	1	204	1	0	0	0	0	1	0	0	0	18208	652	23	3	491	3	ZNF768	16	30536326	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	14738463	30536326	59818427	180	37452											
ITGAD	3681	broad.mit.edu	37	chr16	31422110	31422110	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tacagaacctggtcctggggGccccccgctaccagcatacc	8	6	10	17	1	0	1	0	0	0	1	1	1	1	1	7	3	5	2	7	3	4	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:31422110G>T	uc002ebv.1	+	12	1316	c.1267G>T	c.(1267-1269)GCC>TCC	p.A423S	ITGAD_uc010cap.1_Missense_Mutation_p.A423S	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	423	FG-GAP 4.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						GGTCCTGGGGGCCCCCCGCTA	0.642													25	53					7.38237e-10	9.36656e-10	1	0	T	31422110	T	T	31422110	3	4	204	1	0	0	0	0	1	0	0	0	7923	1203	42	4	1313	4	ITGAD	16	31422110	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	885784	31422110	58932643	181	37453											
RFWD3	55159	broad.mit.edu	37	chr16	74695292	74695292	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccagcaggagctggctgtTgttcggcatgatttaactgc	7	12	13	9	1	0	1	0	1	0	0	1	2	0	2	1	3	5	6	1	3	1	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:74695292T>A	uc002fda.2	-	2	154	c.56A>T	c.(55-57)CAA>CTA	p.Q19L	RFWD3_uc010cgq.2_Missense_Mutation_p.Q19L	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	19					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						AGCTGGCTGTTGTTCGGCATG	0.483													112	170					0	0	0	0	A	74695292	A	A	74695292	3	1	204	1	0	0	0	0	1	0	0	0	13326	1812	63	5	2316	5	RFWD3	16	74695292	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	43273182	74695292	15659461	182	37454											
GAN	8139	broad.mit.edu	37	chr16	81399047	81399047	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagggtagcgagatggtaaCttgcaagtccgagttctacc	10	9	12	10	2	1	1	0	0	1	1	2	3	2	1	3	2	4	4	3	2	4	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr16:81399047C>T	uc002fgo.2	+	9	1614	c.1466C>T	c.(1465-1467)ACT>ATT	p.T489I		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	489	Kelch 5.				cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				GAGATGGTAACTTGCAAGTCC	0.468													93	96					0	0	0	0	T	81399047	T	T	81399047	3	4	204	1	0	0	0	0	1	0	0	0	6267	565	20	4	1500	4	GAN	16	81399047	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	6703755	81399047	8955706	183	37455											
ITGAE	3682	broad.mit.edu	37	chr17	3631298	3631298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttgcaactggtattctgctCcaaagaggttctccccatgt	8	14	8	11	0	2	1	0	0	2	1	4	1	3	1	3	2	3	4	3	2	3	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:3631298C>T	uc002fwo.3	-	26	3098	c.2999G>A	c.(2998-3000)GGA>GAA	p.G1000E		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	1000	Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GTATTCTGCTCCAAAGAGGTT	0.418													36	42					0	0	0	0	T	3631298	T	T	3631298	3	4	204	1	0	0	0	0	1	0	0	0	7924	855	30	2	564	2	ITGAE	17	3631298	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08		3631298	77563912	184	37456											
TP53	7157	broad.mit.edu	37	chr17	7576928	7576928	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggtgttgttgggcagtgcTaggaaagaggcaaggaaagg	11	8	18	4	0	0	1	0	0	0	1	0	3	0	3	0	6	1	5	0	6	4	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:7576928T>C	uc002gim.2	-	9	1114	c.920_splice	c.e9-1	p.A307_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.A307_splice|TP53_uc010cne.1_Splice_Site|TP53_uc010cnf.1_Splice_Site_p.A175_splice|TP53_uc010cng.1_Splice_Site_p.A175_splice|TP53_uc002gii.1_Splice_Site_p.A175_splice|TP53_uc010cnh.1_Splice_Site_p.A307_splice|TP53_uc010cni.1_Splice_Site_p.A307_splice|TP53_uc002gij.2_Splice_Site_p.A307_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(14)|p.0?(7)|p.A307fs*34(1)|p.L308fs*31(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGGCAGTGCTAGGAAAGAGG	0.493		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			46	45					0	0	0	0	C	7576928	C	C	7576928	5	2	204	1	0	0	0	0	0	0	1	0	16448	1536	53	5	364	5	TP53	17	7576928	Splice_Site	SNP	T	TCGA-CV-6948-01A-11D-1912-08	3945630	7576928	73618282	185	37457											
TP53	7157	broad.mit.edu	37	chr17	7577032	7577033	+	Frame_Shift_Del	DEL	CC	-	-																															tgcttacctcgcttagtgctCcctgggggcagctcgtggtg																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:7577032_7577033delCC	uc002gim.2	-	8	1099_1100	c.905_906delGG	c.(904-906)GGGfs	p.G302fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.G302fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.G170fs|TP53_uc010cng.1_Frame_Shift_Del_p.G170fs|TP53_uc002gii.1_Frame_Shift_Del_p.G170fs|TP53_uc010cnh.1_Frame_Shift_Del_p.G302fs|TP53_uc010cni.1_Frame_Shift_Del_p.G302fs|TP53_uc002gij.2_Frame_Shift_Del_p.G302fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	302	Interaction with HIPK1 (By similarity).|Interaction with CARM1.		G -> R (in a sporadic cancer; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in a sporadic cancer; somatic mutation).|G -> V (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G302fs*4(4)|p.?(3)|p.G302E(3)|p.G302G(3)|p.P301_S303delPGS(1)|p.L299fs*2(1)|p.L265_K305del41(1)|p.G302fs*2(1)|p.S303fs*42(1)|p.G293fs*1(1)|p.H296_S303delHHELPPGS(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTTAGTGCTCCCTGGGGGCAG	0.554		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7577033	-	-	7577032	7	5	204	1	0	1	0	1	0	0	0	0	16448	842	30	0	380	0	TP53	17	7577032	Frame_Shift_Del	DEL	CC	TCGA-CV-6948-01A-11D-1912-08	104	7577032	73618178	186	37458											
NOS2	4843	broad.mit.edu	37	chr17	26125804	26125804	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgcatactggtggaatttgGtcttgaacagaaatttccaa	12	14	9	6	0	1	2	0	1	1	1	2	3	2	3	1	3	3	1	1	3	5	5			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:26125804G>C	uc002gzu.2	-	2	296	c.32C>G	c.(31-33)ACC>AGC	p.T11S	NOS2_uc010crh.1_Missense_Mutation_p.T11S|NOS2_uc010wab.1_Missense_Mutation_p.T11S	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	11					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GTGGAATTTGGTCTTGAACAG	0.458													33	33					0	0	0	0	C	26125804	C	C	26125804	3	2	204	1	0	0	0	0	1	0	0	0	10597	1261	44	4	3533	4	NOS2	17	26125804	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	18548772	26125804	55069406	187	37459											
SUPT6H	6830	broad.mit.edu	37	chr17	27009843	27009843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagagcagtttcccgcggagCccttggagctggccaaggat	8	7	14	12	2	0	1	0	0	0	1	1	4	1	4	3	4	3	3	3	4	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:27009843C>T	uc002hby.2	+	14	1786	c.1696C>T	c.(1696-1698)CCC>TCC	p.P566S	SUPT6H_uc010crt.2_Missense_Mutation_p.P566S	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	566					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TCCCGCGGAGCCCTTGGAGCT	0.602													33	46					0	0	0	0	T	27009843	T	T	27009843	3	4	204	1	0	0	0	0	1	0	0	0	15466	739	26	4	1746	4	SUPT6H	17	27009843	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	884039	27009843	54185367	188	37460											
AATF	26574	broad.mit.edu	37	chr17	35306512	35306512	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaccctgaagcggaccccgaGgaaggtgaggccggactggg	9	3	18	11	3	0	2	0	2	0	0	0	7	0	5	4	6	1	0	4	6	2	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:35306512G>A	uc002hni.2	+	1	338	c.87G>A	c.(85-87)GAG>GAA	p.E29E	AATF_uc002hnj.2_RNA	NM_012138	NP_036270	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	29					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)				CGGACCCCGAGGAAGGTGAGG	0.746													3	6					0	0	0	0	A	35306512	A	A	35306512	2	1	204	1	0	0	0	0	0	0	0	1	25	991	35	4		4	AATF	17	35306512	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	8296669	35306512	45888698	189	37461											
KRTAP4-11	653240	broad.mit.edu	37	chr17	39274113	39274113	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcaggggcggcagcagctgGattcacagcaagaggggcgg	10	3	19	9	2	1	1	1	0	0	1	1	2	1	2	0	7	4	5	0	7	1	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:39274113G>A	uc002hvz.2	-	1	494	c.455C>T	c.(454-456)TCC>TTC	p.S152F		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	152	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].|25.					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			gcagcagctggattcacagca	0.239													9	27					0	0	0	0	A	39274113	A	A	39274113	3	1	204	1	0	0	0	0	1	0	0	0	8589	1174	41	2	136	2	KRTAP4-11	17	39274113	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	3967601	39274113	41921097	190	37462											
AKAP1	8165	broad.mit.edu	37	chr17	55189196	55189197	+	Frame_Shift_Ins	INS	-	T	T																															attggcaagcaggggcgctaINStgtgagttttctgaagcaaa																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:55189196_55189197insT	uc002iux.2	+	4	2117_2118	c.1886_1887insT	c.(1885-1887)TATfs	p.Y629fs	AKAP1_uc010wnl.1_Frame_Shift_Ins_p.Y629fs|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Frame_Shift_Ins_p.Y629fs	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	629	KH.				blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					CAGGGGCGCTATGTGAGTTTTC	0.48													---	---	---								T	55189197	T	T	55189196	7	5	204	1	0	1	1	0	0	0	0	0	445	449	16	0	1896	0	AKAP1	17	55189196	Frame_Shift_Ins	INS	-	TCGA-CV-6948-01A-11D-1912-08	15915083	55189196	26006014	191	37463											
RNFT1	51136	broad.mit.edu	37	chr17	58042024	58042024	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgacagcaagaacagcggcaTacaccgcctccagcccttca	12	4	8	17	3	1	1	1	0	0	1	2	2	2	1	4	1	5	2	4	1	3	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:58042024T>C	uc002iya.2	-	1	94	c.1A>G	c.(1-3)ATG>GTG	p.M1V	uc002iye.1_5'Flank|RNFT1_uc002iyb.2_RNA|RNFT1_uc002iyc.2_5'UTR|RNFT1_uc010wop.1_Missense_Mutation_p.M1V|RNFT1_uc002iyd.3_Missense_Mutation_p.M1V	NM_016125	NP_057209	Q5M7Z0	RNFT1_HUMAN	PTD016 protein	1						integral to membrane	zinc ion binding				0	all_cancers(5;1.58e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;7.95e-12)|all cancers(12;1.34e-10)			AACAGCGGCATACACCGCCTC	0.701													6	9					0	0	0	0	C	58042024	C	C	58042024	3	2	204	1	0	0	0	0	1	0	0	0	13566	1406	49	5	1342	5	RNFT1	17	58042024	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	2852828	58042024	23153186	192	37464											
TLK2	11011	broad.mit.edu	37	chr17	60685501	60685501	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagccagtagtaacacctGaagcaaaggtaagttttgtt	15	10	9	7	0	0	1	0	1	0	0	0	1	0	1	2	1	3	6	2	1	6	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:60685501G>C	uc010ddp.2	+	22	2405	c.2137G>C	c.(2137-2139)GAA>CAA	p.E713Q	TLK2_uc002izx.3_Missense_Mutation_p.E539Q|TLK2_uc002izz.3_Missense_Mutation_p.E691Q|TLK2_uc002jaa.3_Missense_Mutation_p.E659Q|TLK2_uc010wpd.1_Missense_Mutation_p.E659Q	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	713	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						AGTAACACCTGAAGCAAAGGT	0.433													35	29					0	0	0	0	C	60685501	C	C	60685501	3	2	204	1	0	0	0	0	1	0	0	0	16010	1291	45	2	2149	2	TLK2	17	60685501	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	2643477	60685501	20509709	193	37465											
RECQL5	9400	broad.mit.edu	37	chr17	73624385	73624385	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaggagacgccaggagcGgagagctggaaggggtcttg	10	6	18	7	2	2	2	1	0	1	2	2	6	2	4	1	6	2	1	1	6	2	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:73624385G>A	uc010dgl.2	-	18	2874	c.2718C>T	c.(2716-2718)TCC>TCT	p.S906S	RECQL5_uc010dgk.2_Silent_p.S879S|RECQL5_uc002jot.3_Silent_p.S102S	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	906					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			CGCCAGGAGCGGAGAGCTGGA	0.597								Other_identified_genes_with_known_or_suspected_DNA_repair_function					8	49					0	0	0	0	A	73624385	A	A	73624385	2	1	204	1	0	0	0	0	0	0	0	1	13268	1103	39	1		1	RECQL5	17	73624385	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	12938884	73624385	7570825	194	37466											
RNF213	57674	broad.mit.edu	37	chr17	78322014	78322014	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactttcacagacagaggcaCaactcctttgcagatttcct	11	12	6	12	0	1	3	1	0	0	3	3	3	3	3	2	1	3	2	2	1	2	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr17:78322014C>A	uc002jyh.1	+	4	4321	c.4098C>A	c.(4096-4098)CAC>CAA	p.H1366Q		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GACAGAGGCACAACTCCTTTG	0.597													3	44					6.4e-05	7.87126e-05	1	0	A	78322014	A	A	78322014	3	1	204	1	0	0	0	0	1	0	0	0	13542	477	17	4	10308	4	RNF213	17	78322014	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	4697629	78322014	2873196	195	37467											
PTPRM	5797	broad.mit.edu	37	chr18	8296397	8296397	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcagtctgcaccatgggActcggctaagaaagatgaga	13	6	14	8	1	1	3	0	1	1	3	2	5	1	4	1	3	1	3	1	3	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr18:8296397A>C	uc002knn.3	+	18	3250	c.2747A>C	c.(2746-2748)GAC>GCC	p.D916A	PTPRM_uc010dkv.2_Missense_Mutation_p.D929A|PTPRM_uc010wzl.1_Missense_Mutation_p.D703A	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	916	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GCACCATGGGACTCGGCTAAG	0.423													3	38					0	0	0	0	C	8296397	C	C	8296397	3	2	204	1	0	0	0	0	1	0	0	0	12871	275	10	5	2864	5	PTPRM	18	8296397	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08		8296397	69780851	196	37468											
ZNF846	162993	broad.mit.edu	37	chr19	9868519	9868519	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccagtgtgaatccttacatGttgactaagcattgaggaat	12	13	9	7	0	0	3	0	3	0	0	2	4	2	4	2	1	2	2	2	1	4	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:9868519G>T	uc002mmb.1	-	6	1765	c.1234C>A	c.(1234-1236)CAT>AAT	p.H412N	ZNF846_uc010xky.1_Intron|ZNF846_uc010xkz.1_Intron|ZNF846_uc010dww.2_Intron|ZNF846_uc002mmc.1_Missense_Mutation_p.H283N	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	412	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATCCTTACATGTTGACTAAGC	0.403													28	52					4.22769e-11	5.40673e-11	1	0	T	9868519	T	T	9868519	3	4	204	1	0	0	0	0	1	0	0	0	18259	1377	48	4	371	4	ZNF846	19	9868519	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08		9868519	49260464	197	37469											
KRI1	65095	broad.mit.edu	37	chr19	10675688	10675688	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagcgttttgtaaaagtccCgctcctgctggggatcaaat	10	11	11	9	2	1	1	1	0	0	1	3	2	3	2	2	2	2	4	2	2	3	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:10675688C>T	uc002moy.1	-	3	218	c.209G>A	c.(208-210)CGG>CAG	p.R70Q	KRI1_uc002mox.1_Missense_Mutation_p.R66Q	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	70										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GTAAAAGTCCCGCTCCTGCTG	0.522											OREG0025239	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	65					0	0	0	0	T	10675688	T	T	10675688	3	4	204	1	0	0	0	0	1	0	0	0	8483	652	23	1	1988	1	KRI1	19	10675688	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	807169	10675688	48453295	198	37470											
CCDC151	115948	broad.mit.edu	37	chr19	11537725	11537725	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgtgtgtctgttttgcgcctCcgccatctccagaaggcgca	5	11	11	14	4	2	1	0	0	2	1	4	1	3	1	4	1	1	2	4	1	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:11537725C>G	uc002mrs.2	-	4	723	c.580G>C	c.(580-582)GAG>CAG	p.E194Q	CCDC151_uc002mrr.2_Missense_Mutation_p.E129Q|CCDC151_uc010dxz.2_Missense_Mutation_p.E168Q	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	194	Potential.									ovary(1)	1						TTTTGCGCCTCCGCCATCTCC	0.677													30	45					0	0	0	0	G	11537725	G	G	11537725	3	3	204	1	0	0	0	0	1	0	0	0	2798	864	30	2	1247	2	CCDC151	19	11537725	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	862037	11537725	47591258	199	37471											
OR7C2	26658	broad.mit.edu	37	chr19	15052714	15052714	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tacacggtcatcatgaacccCcggctctgtggactgctggt	7	10	11	13	2	3	1	2	1	1	0	3	2	3	2	2	4	3	2	2	4	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:15052714C>A	uc010xoc.1	+	1	414	c.414C>A	c.(412-414)CCC>CCA	p.P138P		NM_012377	NP_036509	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Ovarian(108;0.203)					TCATGAACCCCCGGCTCTGTG	0.537													64	115					2.89935e-36	4.01161e-36	1	0	A	15052714	A	A	15052714	2	1	204	1	0	0	0	0	0	0	0	1	11272	610	22	4		4	OR7C2	19	15052714	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	3514989	15052714	44076269	200	37472											
NOTCH3	4854	broad.mit.edu	37	chr19	15288423	15288423	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggcggggtcgcagcggctgTtgttgaagaggcgccagcac	7	6	18	10	4	0	2	0	1	0	1	1	2	0	2	1	5	2	5	1	5	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:15288423T>C	uc002nan.2	-	24	4392	c.4316A>G	c.(4315-4317)AAC>AGC	p.N1439S	NOTCH3_uc002nao.1_Missense_Mutation_p.N1387S	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1439	Extracellular (Potential).|LNR 2.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GCAGCGGCTGTTGTTGAAGAG	0.701													7	2					0	0	0	0	C	15288423	C	C	15288423	3	2	204	1	0	0	0	0	1	0	0	0	10604	1725	60	5	2689	5	NOTCH3	19	15288423	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	235709	15288423	43840560	201	37473											
AKAP8L	26993	broad.mit.edu	37	chr19	15514345	15514345	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtctccaaatgcggcacCatatctaagcgctggttaat	10	12	8	11	2	3	0	0	0	3	0	4	0	3	0	2	2	2	3	2	2	4	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:15514345C>T	uc002naw.1	-	4	402	c.303G>A	c.(301-303)ATG>ATA	p.M101I	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Intron|AKAP8L_uc002nay.1_Missense_Mutation_p.M101I|AKAP8L_uc002naz.2_5'Flank	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	101						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						AATGCGGCACCATATCTAAGC	0.537													65	101					0	0	0	0	T	15514345	T	T	15514345	3	4	204	1	0	0	0	0	1	0	0	0	458	594	21	4	1681	4	AKAP8L	19	15514345	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	225922	15514345	43614638	202	37474											
OR10H5	284433	broad.mit.edu	37	chr19	15905429	15905429	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttgaagttggcctgtggaGatgatgtgctggtggtggcc	5	13	18	5	0	0	3	0	2	0	1	0	4	0	3	2	5	1	3	2	5	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:15905429G>A	uc010xos.1	+	1	571	c.571G>A	c.(571-573)GAT>AAT	p.D191N		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGCCTGTGGAGATGATGTGCT	0.572													6	86					0	0	0	0	A	15905429	A	A	15905429	3	1	204	1	0	0	0	0	1	0	0	0	10963	942	33	2	573	2	OR10H5	19	15905429	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	391084	15905429	43223554	203	37475											
SLC5A5	6528	broad.mit.edu	37	chr19	17988641	17988641	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcgcaggtgcagcgctacGtggcttgccgcacagagaag	9	5	16	11	4	0	1	0	0	0	1	0	2	0	1	1	3	4	5	1	3	2	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:17988641G>A	uc002nhr.3	+	6	1155	c.808G>A	c.(808-810)GTG>ATG	p.V270M		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	270	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GCAGCGCTACGTGGCTTGCCG	0.607													45	67					0	0	0	0	A	17988641	A	A	17988641	3	1	204	1	0	0	0	0	1	0	0	0	14732	1145	40	1	830	1	SLC5A5	19	17988641	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	2083212	17988641	41140342	204	37476											
KIAA1683	80726	broad.mit.edu	37	chr19	18368445	18368445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggactggaagcagcgatggtCagatactgtcctggctctgc	8	9	14	10	1	2	1	1	0	1	1	3	4	3	3	1	4	4	2	1	4	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:18368445C>T	uc002nin.2	-	4	3304	c.3088G>A	c.(3088-3090)GAC>AAC	p.D1030N	PDE4C_uc002nil.3_5'Flank|KIAA1683_uc010ebn.2_Missense_Mutation_p.D1217N|KIAA1683_uc010xqe.1_Missense_Mutation_p.D984N|KIAA1683_uc010xqf.1_RNA	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	1030						mitochondrion				ovary(2)	2						CAGCGATGGTCAGATACTGTC	0.657													25	44					0	0	0	0	T	18368445	T	T	18368445	3	4	204	1	0	0	0	0	1	0	0	0	8290	826	29	2	458	2	KIAA1683	19	18368445	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	379804	18368445	40760538	205	37477											
ZNF737	100129842	broad.mit.edu	37	chr19	20736633	20736633	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggccacgtctctaaattgCaatggcccctgaaacacaca	13	8	7	13	1	1	1	0	1	1	0	2	1	1	1	3	2	2	1	3	2	4	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:20736633C>T	uc002npa.2	-	2	192	c.12G>A	c.(10-12)TTG>TTA	p.L4L		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	4					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CTCTAAATTGCAATGGCCCCT	0.403													36	44					0	0	0	0	T	20736633	T	T	20736633	2	4	204	1	0	0	0	0	0	0	0	1	18193	709	25	4		4	ZNF737	19	20736633	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	2368188	20736633	38392350	206	37478											
ZNF507	22847	broad.mit.edu	37	chr19	32844322	32844322	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagcccaacagtgcgtaagcCcctccagctctttgtgtcgg	8	9	10	14	2	1	0	0	0	1	0	3	0	2	0	4	1	5	2	4	1	3	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:32844322C>T	uc002nte.2	+	3	858	c.586C>T	c.(586-588)CCC>TCC	p.P196S	ZNF507_uc002ntc.2_Missense_Mutation_p.P196S|ZNF507_uc010xrn.1_Missense_Mutation_p.P196S|ZNF507_uc002ntd.2_Missense_Mutation_p.P196S	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					GTGCGTAAGCCCCTCCAGCTC	0.468													37	49					0	0	0	0	T	32844322	T	T	32844322	3	4	204	1	0	0	0	0	1	0	0	0	18020	623	22	4	588	4	ZNF507	19	32844322	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	12107689	32844322	26284661	207	37479											
MLL4	9757	broad.mit.edu	37	chr19	36210733	36210733	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agcataagacgaccccccttCctcctcctcgcctagcagat	9	8	6	18	2	0	2	0	0	0	2	4	3	3	2	7	0	2	2	7	0	2	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:36210733C>T	uc010eei.2	+	3	484	c.484C>T	c.(484-486)CCT>TCT	p.P162S		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	162					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GACCCCCCTTCCTCCTCCTCG	0.607													52	97					0	0	0	0	T	36210733	T	T	36210733	3	4	204	1	0	0	0	0	1	0	0	0	9676	855	30	2	494	2	MLL4	19	36210733	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	3366411	36210733	22918250	208	37480											
HNRNPL	3191	broad.mit.edu	37	chr19	39336596	39336596	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagatcttctggctggtaGagtagttgacaaaagctggg	10	10	16	5	0	2	3	0	1	2	2	2	4	2	3	0	4	1	5	0	4	4	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:39336596G>C	uc010xul.1	-	3	532	c.521C>G	c.(520-522)TCT>TGT	p.S174C	HNRNPL_uc010xum.1_Missense_Mutation_p.S41C|HNRNPL_uc010xun.1_5'Flank	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	174	RRM 1.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CTGGCTGGTAGAGTAGTTGAC	0.522													51	98					0	0	0	0	C	39336596	C	C	39336596	3	2	204	1	0	0	0	0	1	0	0	0	7309	942	33	2	1292	2	HNRNPL	19	39336596	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	3125863	39336596	19792387	209	37481											
CLPTM1	1209	broad.mit.edu	37	chr19	45496120	45496120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagcgagccccaggaagccCctccaaagccagcagaggac	12	1	11	17	1	0	1	0	0	0	1	1	4	1	3	7	2	5	1	7	2	2	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:45496120C>T	uc002pai.2	+	14	1990	c.1975C>T	c.(1975-1977)CCT>TCT	p.P659S	CLPTM1_uc010xxf.1_Missense_Mutation_p.P557S|CLPTM1_uc010xxg.1_Missense_Mutation_p.P645S	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	659	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		CCAGGAAGCCCCTCCAAAGCC	0.682													20	33					0	0	0	0	T	45496120	T	T	45496120	3	4	204	1	0	0	0	0	1	0	0	0	3569	623	22	4	2029	4	CLPTM1	19	45496120	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	6159524	45496120	13632863	210	37482											
MARK4	57787	broad.mit.edu	37	chr19	45762300	45762300	+	Frame_Shift_Del	DEL	C	-	-																															aaaggcccgtcctggtccagCcgctcactgggtgcccgttg																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:45762300delC	uc002pbb.1	+	2	110	c.105delC	c.(103-105)AGCfs	p.S35fs	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Frame_Shift_Del_p.S35fs			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	35					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCTGGTCCAGCCGCTCACTGG	0.662													---	---	---								-	45762300	-	-	45762300	7	5	204	1	0	1	0	1	0	0	0	0	9368	738	26	0	111	0	MARK4	19	45762300	Frame_Shift_Del	DEL	C	TCGA-CV-6948-01A-11D-1912-08	266180	45762300	13366683	211	37483											
CKM	1158	broad.mit.edu	37	chr19	45810135	45810135	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcggacgagcccagccgaTcagcgttggacacgtcaaat	10	7	11	13	5	2	0	2	0	0	0	3	4	2	2	2	2	3	1	2	2	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:45810135T>C	uc002pbd.2	-	8	1093	c.1019A>G	c.(1018-1020)GAT>GGT	p.D340G		NM_001824	NP_001815	P06732	KCRM_HUMAN	muscle creatine kinase	340	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			skin(1)	1		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	GCCCAGCCGATCAGCGTTGGA	0.582													57	116					0	0	0	0	C	45810135	C	C	45810135	3	2	204	1	0	0	0	0	1	0	0	0	3463	1435	50	5	130	5	CKM	19	45810135	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	47835	45810135	13318848	212	37484											
VASP	7408	broad.mit.edu	37	chr19	46027399	46027399	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaacagcacaaccttgccaAggtaggccatcggtcctggg	11	6	12	12	1	0	1	0	0	0	1	2	1	1	1	4	4	4	2	4	4	4	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:46027399A>T	uc002pcg.2	+	10	1297	c.955A>T	c.(955-957)AGG>TGG	p.R319W	VASP_uc010eki.2_Missense_Mutation_p.R153W|VASP_uc002pci.2_Missense_Mutation_p.R305W	NM_003370	NP_003361	P50552	VASP_HUMAN	vasodilator-stimulated phosphoprotein	319	EVH2.				axon guidance|cell junction assembly|T cell receptor signaling pathway	actin cytoskeleton|cytosol|filopodium membrane|focal adhesion|lamellipodium membrane	actin binding|profilin binding|SH3 domain binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0145)|GBM - Glioblastoma multiforme(486;0.154)		AACCTTGCCAAGGTAGGCCAT	0.323											OREG0025556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	29					0	0	0	0	T	46027399	T	T	46027399	3	4	204	1	0	0	0	0	1	0	0	0	17196	86	3	5	993	5	VASP	19	46027399	Missense_Mutation	SNP	A	TCGA-CV-6948-01A-11D-1912-08	217264	46027399	13101584	213	37485											
MYH14	79784	broad.mit.edu	37	chr19	50713685	50713685	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggccgggcccagtgccCgaggcggcccagccgttcct	4	4	14	19	4	0	0	0	0	0	0	1	1	1	0	7	4	2	1	7	4	0	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:50713685C>T	uc002prr.1	+	2	110	c.63C>T	c.(61-63)CCC>CCT	p.P21P	MYH14_uc010enu.1_Silent_p.P21P|MYH14_uc002prq.1_Silent_p.P21P	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	21	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GCCCAGTGCCCGAGGCGGCCC	0.756													5	1					0	0	0	0	T	50713685	T	T	50713685	2	4	204	1	0	0	0	0	0	0	0	1	10086	639	23	1		1	MYH14	19	50713685	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	4686286	50713685	8415298	214	37486											
ZNF845	91664	broad.mit.edu	37	chr19	53854940	53854940	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgtggcaagaccttcagtCaaacgtcataccttgtgtac	12	11	8	10	1	3	1	3	0	0	1	3	1	3	1	2	1	3	2	2	1	5	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:53854940C>G	uc010ydv.1	+	4	1129	c.1012C>G	c.(1012-1014)CAA>GAA	p.Q338E	ZNF845_uc010ydw.1_Missense_Mutation_p.Q338E	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	338	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GACCTTCAGTCAAACGTCATA	0.388													29	50					0	0	0	0	G	53854940	G	G	53854940	3	3	204	1	0	0	0	0	1	0	0	0	18258	827	29	2	1022	2	ZNF845	19	53854940	Missense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	3141255	53854940	5274043	215	37487											
PRKCG	5582	broad.mit.edu	37	chr19	54401792	54401792	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacgatgtggactgcacgctGgtggagaaacgtgtgctggc	8	8	17	8	3	0	1	0	0	0	1	0	5	0	2	0	4	3	3	0	4	1	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr19:54401792G>C	uc002qcq.1	+	11	1473	c.1191G>C	c.(1189-1191)CTG>CTC	p.L397L	PRKCG_uc010yef.1_3'UTR|PRKCG_uc010yeg.1_Silent_p.L397L|PRKCG_uc010yeh.1_Silent_p.L284L	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	397	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACTGCACGCTGGTGGAGAAAC	0.637													13	19					0	0	0	0	C	54401792	C	C	54401792	2	2	204	1	0	0	0	0	0	0	0	1	12574	1335	47	4		4	PRKCG	19	54401792	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	546852	54401792	4727191	216	37488											
C20orf27	54976	broad.mit.edu	37	chr20	3739186	3739186	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtaggtgtgcatgtaccttGaccagaaagctgctgtcact	9	11	12	9	0	1	2	1	1	0	1	1	2	1	2	2	2	4	5	2	2	3	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:3739186G>C	uc002wji.1	-	3	388	c.159C>G	c.(157-159)GTC>GTG	p.V53V	C20orf27_uc002wjf.1_Silent_p.V78V|C20orf27_uc002wjh.1_Silent_p.V78V	NM_001039140	NP_001034229	Q9GZN8	CT027_HUMAN	hypothetical protein LOC54976	53											0						CATGTACCTTGACCAGAAAGC	0.587													7	142					0	0	0	0	C	3739186	C	C	3739186	2	2	204	1	0	0	0	0	0	0	0	1	2117	1277	45	2		2	C20orf27	20	3739186	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08		3739186	59286334	217	37489											
RIN2	54453	broad.mit.edu	37	chr20	19937366	19937366	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggctcagcatcttggaccGgctcctccacacccacccca	8	6	7	20	1	2	0	1	0	1	0	4	1	4	1	6	3	1	3	6	3	0	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:19937366G>A	uc002wro.1	+	3	302	c.266G>A	c.(265-267)CGG>CAG	p.R89Q	RIN2_uc010gcu.1_Missense_Mutation_p.R89Q|RIN2_uc010gcv.1_5'UTR	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	89					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						ATCTTGGACCGGCTCCTCCAC	0.607													4	29					0	0	0	0	A	19937366	A	A	19937366	3	1	204	1	0	0	0	0	1	0	0	0	13437	1116	39	1	276	1	RIN2	20	19937366	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	16198180	19937366	43088154	218	37490											
ENTPD6	955	broad.mit.edu	37	chr20	25197285	25197285	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgcttgctgtgctccaggCagcttgaaaactccaggagg	8	11	12	10	0	0	1	0	1	0	0	2	2	2	2	2	3	5	5	2	3	2	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:25197285C>A	uc002wuj.2	+	8	891	c.711C>A	c.(709-711)GGC>GGA	p.G237G	ENTPD6_uc010zsy.1_Silent_p.G237G|ENTPD6_uc010gdj.1_Silent_p.G209G|ENTPD6_uc010zsz.1_Silent_p.G19G|ENTPD6_uc002wum.2_Silent_p.G220G|ENTPD6_uc010zta.1_Silent_p.G237G|ENTPD6_uc002wun.2_Silent_p.G237G|ENTPD6_uc002wuk.2_Silent_p.G236G|ENTPD6_uc002wul.2_Silent_p.G236G|ENTPD6_uc010ztb.1_Silent_p.G209G|ENTPD6_uc010ztc.1_Silent_p.G209G|ENTPD6_uc002wuo.2_Intron|ENTPD6_uc010ztd.1_Silent_p.G19G	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	237	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						GTGCTCCAGGCAGCTTGAAAA	0.572													9	17					4.68919e-08	5.85693e-08	1	0	A	25197285	A	A	25197285	2	1	204	1	0	0	0	0	0	0	0	1	5167	724	25	4		4	ENTPD6	20	25197285	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	5259919	25197285	37828235	219	37491											
DEFB116	245930	broad.mit.edu	37	chr20	29891043	29891043	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagagtagcttgaactgtttGtaactgacaagttggagtta	12	13	12	4	0	0	3	0	2	0	1	0	5	0	4	0	1	3	6	0	1	5	6			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:29891043G>T	uc010ztm.1	-	2	281	c.281C>A	c.(280-282)ACA>AAA	p.T94K		NM_001037731	NP_001032820	Q30KQ4	DB116_HUMAN	beta-defensin 116 precursor	94					defense response to bacterium	extracellular region					0	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TGAACTGTTTGTAACTGACAA	0.383													83	183					3.76054e-38	5.2484e-38	1	0	T	29891043	T	T	29891043	3	4	204	1	0	0	0	0	1	0	0	0	4426	1377	48	4	30	4	DEFB116	20	29891043	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	4693758	29891043	33134477	220	37492											
SUN5	140732	broad.mit.edu	37	chr20	31587898	31587898	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgaaagcacagaggagcaGaatgcctgtcttctccatga	13	7	10	11	1	2	3	0	1	2	2	3	5	2	4	3	1	3	2	3	1	2	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:31587898G>C	uc002wyi.2	-	5	415	c.322C>G	c.(322-324)CTG>GTG	p.L108V		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	108					spermatogenesis					skin(1)	1						CAGAGGAGCAGAATGCCTGTC	0.483													13	71					0	0	0	0	C	31587898	C	C	31587898	3	2	204	1	0	0	0	0	1	0	0	0	15460	933	33	2	853	2	SUN5	20	31587898	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	1696855	31587898	31437622	221	37493											
ACSS2	55902	broad.mit.edu	37	chr20	33502206	33502206	+	Frame_Shift_Del	DEL	C	-	-																															gggtgactccaccagccagtCccccccaattaagaggtcat																										TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:33502206delC	uc002xbd.2	+	7	921	c.800delC	c.(799-801)TCCfs	p.S267fs	ACSS2_uc002xbc.2_Frame_Shift_Del_p.S172fs|ACSS2_uc010zum.1_Intron|ACSS2_uc010gey.2_Frame_Shift_Del_p.S267fs|ACSS2_uc002xbe.2_Intron|ACSS2_uc002xbf.2_Intron	NM_018677	NP_061147	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	267					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding				0					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	ACCAGCCAGTCCCCCCCAATT	0.537													---	---	---								-	33502206	-	-	33502206	7	5	204	1	0	1	0	1	0	0	0	0	189	855	30	0	826	0	ACSS2	20	33502206	Frame_Shift_Del	DEL	C	TCGA-CV-6948-01A-11D-1912-08	1914308	33502206	29523314	222	37494											
PHF20	51230	broad.mit.edu	37	chr20	34505531	34505531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggatgaccgctatgacttcGaggtggtccgctgcatctgt	6	11	14	10	3	1	2	0	2	1	0	3	4	2	3	2	3	1	3	2	3	1	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:34505531G>A	uc002xek.1	+	13	2062	c.1951G>A	c.(1951-1953)GAG>AAG	p.E651K		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	651					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CTATGACTTCGAGGTGGTCCG	0.502													21	52					0	0	0	0	A	34505531	A	A	34505531	3	1	204	1	0	0	0	0	1	0	0	0	11886	1059	37	1	1997	1	PHF20	20	34505531	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	1003325	34505531	28519989	223	37495											
SFRS6	6431	broad.mit.edu	37	chr20	42087030	42087030	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggagttcgaggactcccGcgacgccgacgacgccgttt	6	7	14	14	9	0	0	0	0	0	0	2	6	1	2	3	2	0	2	3	2	0	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:42087030G>T	uc010zwg.1	+	2	307	c.137G>T	c.(136-138)CGC>CTC	p.R46L	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Missense_Mutation_p.R46L	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	46	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GAGGACTCCCGCGACGCCGAC	0.721													4	0					0.00024832	0.000298542	1	0	T	42087030	T	T	42087030	3	4	204	1	0	0	0	0	1	0	0	0	14246	1087	38	3	143	3	SFRS6	20	42087030	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	7581499	42087030	20938490	224	37496											
ZNF831	128611	broad.mit.edu	37	chr20	57769026	57769026	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcatttgttgggtcaggactGgggacccctctttctcccag	5	13	11	12	0	4	0	2	0	2	0	5	2	4	2	3	4	0	1	3	4	0	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr20:57769026G>T	uc002yan.2	+	1	2952	c.2952G>T	c.(2950-2952)CTG>CTT	p.L984L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	984						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGTCAGGACTGGGGACCCCTC	0.632													34	15					3.11337e-16	4.12972e-16	1	0	T	57769026	T	T	57769026	2	4	204	1	0	0	0	0	0	0	0	1	18252	1335	47	4		4	ZNF831	20	57769026	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	15681996	57769026	5256494	225	37497											
MORC3	23515	broad.mit.edu	37	chr21	37741537	37741537	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accttgtggccagactggttCaacaagcacctcatcatccc	10	9	7	15	0	3	1	3	0	0	1	4	1	4	1	4	2	2	2	4	2	2	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr21:37741537C>G	uc002yvi.2	+	15	1947	c.1871C>G	c.(1870-1872)TCA>TGA	p.S624*		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	624					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						CAGACTGGTTCAACAAGCACC	0.448													33	78					0	0	0	0	G	37741537	G	G	37741537	4	3	204	1	0	0	0	0	0	1	0	0	9756	838	29	2	1929	2	MORC3	21	37741537	Nonsense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08		37741537	10388358	226	37498											
SLC37A1	54020	broad.mit.edu	37	chr21	43962541	43962541	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgggctggtgcagaccaccGgctggcccagcgtcgtcacc	6	5	14	16	4	1	1	1	0	0	1	2	1	1	1	4	4	2	3	4	4	0	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr21:43962541G>A	uc002zbi.2	+	8	926	c.514G>A	c.(514-516)GGC>AGC	p.G172S	SLC37A1_uc002zbj.2_Missense_Mutation_p.G172S	NM_018964	NP_061837	P57057	GLPT_HUMAN	solute carrier family 37 member 1	172	Helical; (Potential).				carbohydrate transport|transmembrane transport	integral to membrane					0						GCAGACCACCGGCTGGCCCAG	0.577													18	28					0	0	0	0	A	43962541	A	A	43962541	3	1	204	1	0	0	0	0	1	0	0	0	14661	1116	39	1	536	1	SLC37A1	21	43962541	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	6221004	43962541	4167354	227	37499											
POTEH	23784	broad.mit.edu	37	chr22	16279295	16279295	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accaagtaacagtggtgtgaGgccatgctgtaaaacaatat	15	9	10	7	0	0	1	0	1	0	0	0	1	0	1	2	2	3	3	2	2	6	3			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr22:16279295G>T	uc010gqp.2	-	4	980	c.928C>A	c.(928-930)CTC>ATC	p.L310I	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.L29I|POTEH_uc002zlj.1_Missense_Mutation_p.L145I	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	310	ANK 5.									skin(1)	1						AGTGGTGTGAGGCCATGCTGT	0.323													36	510					2.215e-12	2.84667e-12	1	0	T	16279295	T	T	16279295	3	4	204	1	0	0	0	0	1	0	0	0	12322	1000	35	4	737	4	POTEH	22	16279295	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08		16279295	35025271	228	37500											
ZNF280A	129025	broad.mit.edu	37	chr22	22868743	22868743	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttccacatcagcaaagacCgacgatctgtaatggcaaac	14	8	8	11	2	2	1	1	0	1	1	3	3	3	1	2	1	2	4	2	1	3	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr22:22868743C>T	uc002zwe.2	-	2	1465	c.1212G>A	c.(1210-1212)TCG>TCA	p.S404S	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		CAGCAAAGACCGACGATCTGT	0.413													6	116					0	0	0	0	T	22868743	T	T	22868743	2	4	204	1	0	0	0	0	0	0	0	1	17881	639	23	1		1	ZNF280A	22	22868743	Silent	SNP	C	TCGA-CV-6948-01A-11D-1912-08	6589448	22868743	28435823	229	37501											
TCF20	6942	broad.mit.edu	37	chr22	42606032	42606032	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctcagtgtccgtcttGgagccattagaagcactttt	7	14	8	12	1	2	1	1	0	1	1	5	2	5	2	4	1	2	1	4	1	2	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chr22:42606032G>A	uc003bcj.1	-	1	5414	c.5280C>T	c.(5278-5280)TCC>TCT	p.S1760S	TCF20_uc003bck.1_Silent_p.S1760S|TCF20_uc003bnt.2_Silent_p.S1760S	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1760					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						TGTCCGTCTTGGAGCCATTAG	0.557													42	88					0	0	0	0	A	42606032	A	A	42606032	2	1	204	1	0	0	0	0	0	0	0	1	15756	1335	47	4		4	TCF20	22	42606032	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08	19737289	42606032	8698534	230	37502											
MAGEB6	158809	broad.mit.edu	37	chrX	26212041	26212041	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtcagccacagggtctcacGggtccccaggccactgcaga	8	5	13	15	1	2	1	2	0	1	1	4	1	3	1	4	4	2	1	4	4	0	0			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chrX:26212041G>C	uc004dbr.2	+	2	227	c.78G>C	c.(76-78)ACG>ACC	p.T26T	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	26										ovary(3)	3						AGGGTCTCACGGGTCCCCAGG	0.572													30	16					0	0	0	0	C	26212041	C	C	26212041	2	2	204	1	0	0	0	0	0	0	0	1	9232	1103	39	3		3	MAGEB6	23	26212041	Silent	SNP	G	TCGA-CV-6948-01A-11D-1912-08		26212041	129058519	231	37503											
MAGED1	9500	broad.mit.edu	37	chrX	51639730	51639730	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagagccctccagctaggCagaccccaccagcctggcag	9	4	11	17	0	1	2	1	0	0	2	2	2	2	2	6	2	3	3	6	2	1	1			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chrX:51639730C>T	uc004dpm.2	+	4	1074	c.979C>T	c.(979-981)CAG>TAG	p.Q327*	MAGED1_uc004dpn.2_Nonsense_Mutation_p.Q383*|MAGED1_uc004dpo.2_Nonsense_Mutation_p.Q327*	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	327	Pro-rich.|22 X 6 AA tandem repeats of W-[PQ]-X-P-X- X.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					TCCAGCTAGGCAGACCCCACC	0.602										Multiple Myeloma(10;0.10)			30	9					0	0	0	0	T	51639730	T	T	51639730	4	4	204	1	0	0	0	0	0	1	0	0	9236	711	25	4	1161	4	MAGED1	23	51639730	Nonsense_Mutation	SNP	C	TCGA-CV-6948-01A-11D-1912-08	25427689	51639730	103630830	232	37504											
NRK	203447	broad.mit.edu	37	chrX	105179222	105179222	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaaccctctgaagtcaatgTtaacccactctatgtctctc	10	12	5	14	0	4	1	1	1	3	0	6	1	4	1	2	0	2	2	2	0	5	2			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chrX:105179222T>C	uc004emd.2	+	21	3863	c.3560T>C	c.(3559-3561)GTT>GCT	p.V1187A	NRK_uc010npc.1_Missense_Mutation_p.V855A	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1187							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GAAGTCAATGTTAACCCACTC	0.418										HNSCC(51;0.14)			61	26					0	0	0	0	C	105179222	C	C	105179222	3	2	204	1	0	0	0	0	1	0	0	0	10709	1725	60	5	3642	5	NRK	23	105179222	Missense_Mutation	SNP	T	TCGA-CV-6948-01A-11D-1912-08	53539492	105179222	50091338	233	37505											
GPR112	139378	broad.mit.edu	37	chrX	135439890	135439890	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agagagaaggacaagaaatgGctacaatttcctatgtacca	17	8	9	7	0	0	3	0	0	0	3	1	5	1	4	2	2	2	2	2	2	7	4			TCGA-CV-6948-01A-11D-1912-08	TCGA-CV-6948-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	03eb2650-4b9f-46d2-b09f-378d8e919ae2	0a473b19-15a2-42aa-9307-2b830a2476e1	g.chrX:135439890G>C	uc004ezu.1	+	10	7246	c.6955G>C	c.(6955-6957)GCT>CCT	p.A2319P	GPR112_uc010nsb.1_Missense_Mutation_p.A2114P|GPR112_uc010nsc.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2319	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACAAGAAATGGCTACAATTTC	0.348													5	126					0	0	0	0	C	135439890	C	C	135439890	3	2	204	1	0	0	0	0	1	0	0	0	6667	1203	42	4	6981	4	GPR112	23	135439890	Missense_Mutation	SNP	G	TCGA-CV-6948-01A-11D-1912-08	30260668	135439890	19830670	234	37506											
PIK3R3	8503	broad.mit.edu	37	chr1	46511672	46511672	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcccataaagcaagtcctCtgcttgtactcgattgatat	10	15	6	10	1	1	1	0	1	1	0	4	2	3	1	2	0	3	3	2	0	5	6			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr1:46511672C>T	uc001cpb.3	-	9	1861	c.1105G>A	c.(1105-1107)GAG>AAG	p.E369K	PIK3R3_uc009vyb.2_Missense_Mutation_p.E310K|PIK3R3_uc009vyc.2_Missense_Mutation_p.E386K|PIK3R3_uc001cpc.3_Missense_Mutation_p.E369K|PIK3R3_uc010olw.1_Missense_Mutation_p.E415K|PIK3R3_uc010olv.1_Missense_Mutation_p.E159K	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	369	SH2 2.				insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					AGCAAGTCCTCTGCTTGTACT	0.398													20	80					0	0	0	0	T	46511672	T	T	46511672	3	4	205	1	0	0	0	0	1	0	0	0	11975	922	32	2	288	2	PIK3R3	1	46511672	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08		46511672	202738949	1	37507											
ASPM	259266	broad.mit.edu	37	chr1	197091638	197091638	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtagtacgctgacatatagCgtcaaatggcacatagcaag	15	8	10	8	2	1	1	1	1	0	0	1	1	1	1	0	1	3	5	0	1	7	5			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr1:197091638C>A	uc001gtu.2	-	14	3735	c.3478G>T	c.(3478-3480)GCT>TCT	p.A1160S	ASPM_uc001gtv.2_Missense_Mutation_p.A1160S|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1160	CH 2.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TGACATATAGCGTCAAATGGC	0.413													5	12					1.23904e-05	2.61407e-05	1	0	A	197091638	A	A	197091638	3	1	205	1	0	0	0	0	1	0	0	0	1058	768	27	3	7015	3	ASPM	1	197091638	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	150579966	197091638	52158983	2	37508											
PGBD2	267002	broad.mit.edu	37	chr1	249212056	249212056	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggtcaacatttgctccaatGctgtgggcatagagccagtg	9	11	12	9	0	1	1	1	0	0	1	2	1	2	1	2	2	4	3	2	2	3	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr1:249212056G>T	uc001ifh.2	+	3	1420	c.1273G>T	c.(1273-1275)GCT>TCT	p.A425S	PGBD2_uc001ifg.2_Missense_Mutation_p.A174S|PGBD2_uc009xhd.2_Missense_Mutation_p.A422S	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	425										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TTGCTCCAATGCTGTGGGCAT	0.517													7	38					5.18039e-06	1.13444e-05	1	0	T	249212056	T	T	249212056	3	4	205	1	0	0	0	0	1	0	0	0	11836	1319	46	4	1279	4	PGBD2	1	249212056	Missense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08	52120418	249212056	38565	3	37509											
SF3B1	23451	broad.mit.edu	37	chr2	198285265	198285265	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgctcagcaaatggatcaTactgaaaagaggtatgtctc	13	11	10	7	0	3	2	2	1	1	1	4	3	3	3	0	2	3	3	0	2	5	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr2:198285265T>C	uc002uue.2	-	4	350	c.302A>G	c.(301-303)TAT>TGT	p.Y101C	SF3B1_uc010fsk.1_RNA|SF3B1_uc002uuf.2_Missense_Mutation_p.Y101C|SF3B1_uc002uug.2_Missense_Mutation_p.Y101C	NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	101					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AAATGGATCATACTGAAAAGA	0.358													37	23					0	0	0	0	C	198285265	C	C	198285265	3	2	205	1	0	0	0	0	1	0	0	0	14214	1420	49	5	3724	5	SF3B1	2	198285265	Missense_Mutation	SNP	T	TCGA-CV-6950-01A-11D-1912-08		198285265	44914108	4	37510											
KIF1A	547	broad.mit.edu	37	chr2	241689923	241689923	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgattgccacacggtgtaccAggggaacggggtacagcagg	10	5	16	10	3	0	0	0	0	0	0	0	2	0	1	2	6	5	3	2	6	3	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr2:241689923A>G	uc002vzy.2	-	26	2743	c.2597T>C	c.(2596-2598)CTG>CCG	p.L866P	KIF1A_uc010fzk.2_Missense_Mutation_p.L967P|KIF1A_uc002vzz.1_Missense_Mutation_p.L967P	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	866					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ACGGTGTACCAGGGGAACGGG	0.652													3	52					0	0	0	0	G	241689923	G	G	241689923	3	3	205	1	0	0	0	0	1	0	0	0	8322	188	7	5	2563	5	KIF1A	2	241689923	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08	43404658	241689923	1509450	5	37511											
PARP15	165631	broad.mit.edu	37	chr3	122354785	122354785	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgagtacttactggagtcttCacaaagggacgtgcaggatt	11	10	12	8	2	2	0	1	0	1	0	2	4	2	3	0	3	3	2	0	3	3	4			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr3:122354785C>T	uc003efm.2	+	12	1941	c.1875C>T	c.(1873-1875)TTC>TTT	p.F625F	PARP15_uc003efn.2_Silent_p.F430F|PARP15_uc003efo.1_Silent_p.F372F|PARP15_uc003efp.1_Silent_p.F391F|PARP15_uc011bjt.1_Silent_p.F322F	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	603	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		CTGGAGTCTTCACAAAGGGAC	0.488													16	40					0	0	0	0	T	122354785	T	T	122354785	2	4	205	1	0	0	0	0	0	0	0	1	11513	825	29	2		2	PARP15	3	122354785	Silent	SNP	C	TCGA-CV-6950-01A-11D-1912-08		122354785	75667645	6	37512											
DNAJC13	23317	broad.mit.edu	37	chr3	132219737	132219737	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcatcatcaaggatctctgtCgggtactatattttggcaag	10	13	10	8	1	3	0	2	0	1	0	5	1	3	1	0	3	1	3	0	3	5	5			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr3:132219737C>T	uc003eor.2	+	39	4581	c.4516C>T	c.(4516-4518)CGG>TGG	p.R1506W		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1506							heat shock protein binding			ovary(1)|breast(1)	2						GGATCTCTGTCGGGTACTATA	0.373													35	79					0	0	0	0	T	132219737	T	T	132219737	3	4	205	1	0	0	0	0	1	0	0	0	4654	875	31	1	4666	1	DNAJC13	3	132219737	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	9864952	132219737	65802693	7	37513											
MED12L	116931	broad.mit.edu	37	chr3	151112629	151112629	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaacagcgacttctcaggCaagcccagactcggcctttc	10	7	9	15	2	1	1	1	0	1	1	4	2	1	1	2	2	4	2	2	2	2	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr3:151112629C>T	uc003eyp.2	+	37	5727	c.5689C>T	c.(5689-5691)CAA>TAA	p.Q1897*	MED12L_uc011bnz.1_Nonsense_Mutation_p.Q1757*	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1897	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACTTCTCAGGCAAGCCCAGAC	0.512													16	101					0	0	0	0	T	151112629	T	T	151112629	4	4	205	1	0	0	0	0	0	1	0	0	9482	711	25	4	5835	4	MED12L	3	151112629	Nonsense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	18892892	151112629	46909801	8	37514											
DGKG	1608	broad.mit.edu	37	chr3	185975671	185975671	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccaaaatccagccaactgtCccatctccaccacaggccaa	13	6	4	18	0	1	0	0	0	1	0	5	0	4	0	7	1	2	0	7	1	4	0			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr3:185975671C>T	uc003fqa.2	-	17	2019	c.1482G>A	c.(1480-1482)GGG>GGA	p.G494G	DGKG_uc003fqb.2_Silent_p.G455G|DGKG_uc003fqc.2_Silent_p.G469G|DGKG_uc011brx.1_Silent_p.G435G	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	494	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	AGCCAACTGTCCCATCTCCAC	0.448													46	63					0	0	0	0	T	185975671	T	T	185975671	2	4	205	1	0	0	0	0	0	0	0	1	4491	842	30	2		2	DGKG	3	185975671	Silent	SNP	C	TCGA-CV-6950-01A-11D-1912-08	34863042	185975671	12046759	9	37515											
PGM2	55276	broad.mit.edu	37	chr4	37848566	37848566	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagtggtgaatggagggTgttttcaggcaatgagttgg	8	14	16	3	0	2	2	2	2	0	0	2	3	2	3	0	5	0	3	0	5	2	4			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr4:37848566T>G	uc011byb.1	+	9	1095	c.1022T>G	c.(1021-1023)GTG>GGG	p.V341G	PGM2_uc011bya.1_Missense_Mutation_p.V202G|PGM2_uc011byc.1_Missense_Mutation_p.V181G	NM_018290	NP_060760	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	341					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			ovary(1)	1						GAATGGAGGGTGTTTTCAGGC	0.428													8	73					0	0	0	0	G	37848566	G	G	37848566	3	3	205	1	0	0	0	0	1	0	0	0	11853	1696	59	5	1056	5	PGM2	4	37848566	Missense_Mutation	SNP	T	TCGA-CV-6950-01A-11D-1912-08		37848566	153305710	10	37516											
CWH43	80157	broad.mit.edu	37	chr4	49030675	49030675	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaggtctctgctgccatCtggcctttcaggtttggata	8	13	11	9	0	3	1	1	0	2	1	4	2	3	2	2	4	2	2	2	4	2	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr4:49030675C>A	uc003gyv.2	+	10	1478	c.1296C>A	c.(1294-1296)ATC>ATA	p.I432I	CWH43_uc011bzl.1_Silent_p.I405I	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	432					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						CTGCTGCCATCTGGCCTTTCA	0.448													9	32					1.76689e-08	4.07563e-08	1	0	A	49030675	A	A	49030675	2	1	205	1	0	0	0	0	0	0	0	1	4090	903	32	2		2	CWH43	4	49030675	Silent	SNP	C	TCGA-CV-6950-01A-11D-1912-08	11182109	49030675	142123601	11	37517											
ADH1C	126	broad.mit.edu	37	chr4	100268199	100268199	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccccttctcaaacactttCcacgatgccggctgcctcat	8	10	5	18	2	2	0	2	0	1	0	4	1	3	0	5	1	3	1	5	1	1	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr4:100268199C>T	uc003huu.2	-	3	308	c.223G>A	c.(223-225)GAA>AAA	p.E75K		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	75					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	CAAACACTTTCCACGATGCCG	0.512									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				56	189					0	0	0	0	T	100268199	T	T	100268199	3	4	205	1	0	0	0	0	1	0	0	0	309	864	30	2	932	2	ADH1C	4	100268199	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	51237524	100268199	90886077	12	37518											
SYNPO2	171024	broad.mit.edu	37	chr4	119951990	119951990	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aacaggaatattgcaggaggCcaaaaggagaagcacgacaa	19	3	12	7	1	0	1	0	0	0	1	0	5	0	3	1	4	3	2	1	4	7	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr4:119951990C>A	uc003icm.3	+	4	2256	c.2060C>A	c.(2059-2061)GCC>GAC	p.A687D	SYNPO2_uc010ina.2_Missense_Mutation_p.A687D|SYNPO2_uc010inb.2_Missense_Mutation_p.A687D|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.A615D	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	687						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						TTGCAGGAGGCCAAAAGGAGA	0.463													11	34					1.58986e-06	3.52624e-06	1	0	A	119951990	A	A	119951990	3	1	205	1	0	0	0	0	1	0	0	0	15523	739	26	4	2074	4	SYNPO2	4	119951990	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	19683791	119951990	71202286	13	37519											
ANKH	56172	broad.mit.edu	37	chr5	14758681	14758681	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacatggtgcagtttattgaTaatgtagtatcctaaatcac	13	14	7	7	0	1	1	1	1	0	0	2	1	2	1	1	1	1	4	1	1	6	7			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr5:14758681T>A	uc003jfm.3	-	3	671	c.340A>T	c.(340-342)ATC>TTC	p.I114F		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	114	Extracellular (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						AGTTTATTGATAATGTAGTAT	0.418													12	47					0	0	0	0	A	14758681	A	A	14758681	3	1	205	1	0	0	0	0	1	0	0	0	627	1406	49	5	1178	5	ANKH	5	14758681	Missense_Mutation	SNP	T	TCGA-CV-6950-01A-11D-1912-08		14758681	166156579	14	37520											
PCDHGA3	56112	broad.mit.edu	37	chr5	140724693	140724693	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagagggcaccgttggaagaGaaattgctcttatcgacgtg	12	9	13	7	3	1	2	0	0	1	2	2	5	1	3	1	2	1	3	1	2	4	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr5:140724693G>C	uc003ljm.1	+	1	1093	c.1093G>C	c.(1093-1095)GAA>CAA	p.E365Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.E125Q|PCDHGA3_uc011dap.1_Missense_Mutation_p.E365Q	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	365	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTTGGAAGAGAAATTGCTCT	0.443													34	44					0	0	0	0	C	140724693	C	C	140724693	3	2	205	1	0	0	0	0	1	0	0	0	11609	943	33	2	1095	2	PCDHGA3	5	140724693	Missense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08	125966012	140724693	40190567	15	37521											
RNF145	153830	broad.mit.edu	37	chr5	158630622	158630622	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctccagtttctcctttgcagCcatgttgtttttttttttct	3	23	5	10	0	2	0	0	0	2	0	4	0	3	0	3	0	2	4	3	0	0	8			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr5:158630622C>A	uc003lxp.2	-	2	317	c.4G>T	c.(4-6)GCT>TCT	p.A2S	RNF145_uc011ddy.1_Missense_Mutation_p.A16S|RNF145_uc003lxo.1_Missense_Mutation_p.A30S|RNF145_uc011ddz.1_Missense_Mutation_p.A19S|RNF145_uc010jiq.1_Missense_Mutation_p.A32S|RNF145_uc011dea.1_Missense_Mutation_p.A18S	NM_144726	NP_653327	Q96MT1	RN145_HUMAN	ring finger protein 145	2						integral to membrane	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTTTGCAGCCATGTTGttt	0.363													15	30					6.31663e-08	1.43786e-07	1	0	A	158630622	A	A	158630622	3	1	205	1	0	0	0	0	1	0	0	0	13512	739	26	4	2027	4	RNF145	5	158630622	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	17905929	158630622	22284638	16	37522											
TBC1D9B	23061	broad.mit.edu	37	chr5	179320402	179320402	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgtccacacggatgctctCggggaagagcagggtggcgt	7	7	18	9	3	1	1	0	0	1	1	3	3	2	3	1	6	2	2	1	6	1	0			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr5:179320402C>T	uc003mlh.2	-	5	680	c.643G>A	c.(643-645)GAG>AAG	p.E215K	TBC1D9B_uc003mli.2_Missense_Mutation_p.E215K|TBC1D9B_uc003mlj.2_Missense_Mutation_p.E215K	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	215						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGATGCTCTCGGGGAAGAGC	0.587													17	14					0	0	0	0	T	179320402	T	T	179320402	3	4	205	1	0	0	0	0	1	0	0	0	15694	893	31	1	3181	1	TBC1D9B	5	179320402	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	20689780	179320402	1594858	17	37523											
FRS3	10817	broad.mit.edu	37	chr6	41738404	41738404	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggttttcctggcggtgcCatcgtctcggggcagagctc	3	10	15	13	4	1	1	0	0	1	1	5	1	2	1	3	5	2	3	3	5	0	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr6:41738404C>A	uc003orc.1	-	7	1676	c.1432G>T	c.(1432-1434)GGC>TGC	p.G478C		NM_006653	NP_006644	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	478					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			ovary(2)	2	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTGGCGGTGCCATCGTCTCGG	0.627													17	64					3.41278e-10	8.08783e-10	1	0	A	41738404	A	A	41738404	3	1	205	1	0	0	0	0	1	0	0	0	6096	594	21	4	50	4	FRS3	6	41738404	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08		41738404	129376663	18	37524											
PKHD1	5314	broad.mit.edu	37	chr6	51524466	51524466	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaggtacttttgttcccCaatagaaaaaagcgcaaaac	15	10	8	8	1	0	1	0	0	0	1	1	2	1	2	2	2	3	3	2	2	8	6			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr6:51524466C>T	uc003pah.1	-	61	10734	c.10458G>A	c.(10456-10458)TTG>TTA	p.L3486L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3486	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TTTTGTTCCCCAATAGAAAAA	0.453													14	32					0	0	0	0	T	51524466	T	T	51524466	2	4	205	1	0	0	0	0	0	0	0	1	12026	593	21	4		4	PKHD1	6	51524466	Silent	SNP	C	TCGA-CV-6950-01A-11D-1912-08	9786062	51524466	119590601	19	37525											
FAM135A	57579	broad.mit.edu	37	chr6	71247998	71247998	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatatgactctctaggtctCtggtttatgcagaaatggaa	12	14	9	6	0	2	2	0	1	2	1	4	3	2	3	0	3	1	2	0	3	6	5			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr6:71247998C>T	uc003pfj.2	+	18	4255	c.4122C>T	c.(4120-4122)CTC>CTT	p.L1374L	FAM135A_uc003pfi.2_Silent_p.L1178L|FAM135A_uc003pfh.2_Silent_p.L1161L|FAM135A_uc003pfl.2_Silent_p.L1041L|FAM135A_uc003pfn.2_Silent_p.L580L|FAM135A_uc003pfo.1_Silent_p.L745L|FAM135A_uc010kan.1_Intron	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	1374										central_nervous_system(1)	1						CTCTAGGTCTCTGGTTTATGC	0.308													11	14					0	0	0	0	T	71247998	T	T	71247998	2	4	205	1	0	0	0	0	0	0	0	1	5476	900	32	2		2	FAM135A	6	71247998	Silent	SNP	C	TCGA-CV-6950-01A-11D-1912-08	19723532	71247998	99867069	20	37526											
TBX20	57057	broad.mit.edu	37	chr7	35288434	35288434	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacccccgaaaaggacacccGgatggttggaaacatcctcc	12	5	9	15	2	0	0	0	0	0	0	2	4	2	3	5	4	1	1	5	4	3	1			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr7:35288434G>C	uc011kas.1	-	3	411	c.400C>G	c.(400-402)CGG>GGG	p.R134G		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	134	T-box.					nucleus	DNA binding			central_nervous_system(1)	1						AAGGACACCCGGATGGTTGGA	0.478													5	48					0	0	0	0	C	35288434	C	C	35288434	3	2	205	1	0	0	0	0	1	0	0	0	15722	1115	39	3	968	3	TBX20	7	35288434	Missense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08		35288434	123850229	21	37527											
URGCP	55665	broad.mit.edu	37	chr7	43917489	43917489	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccgcctcagctcagcccTgtgcttctcaggggggtcca	4	8	12	17	2	3	0	3	0	1	0	5	0	4	0	5	3	3	2	5	3	0	1			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr7:43917489T>C	uc003tiw.2	-	6	1630	c.1573A>G	c.(1573-1575)AGG>GGG	p.R525G	URGCP_uc003tiu.2_Missense_Mutation_p.R482G|URGCP_uc003tiv.2_Missense_Mutation_p.R450G|URGCP_uc003tix.2_Missense_Mutation_p.R516G|URGCP_uc003tiy.2_Missense_Mutation_p.R482G|URGCP_uc003tiz.2_Missense_Mutation_p.R482G|URGCP_uc011kbj.1_Missense_Mutation_p.R482G	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	525					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						AGCTCAGCCCTGTGCTTCTCA	0.647													3	89					0	0	0	0	C	43917489	C	C	43917489	3	2	205	1	0	0	0	0	1	0	0	0	17094	1579	55	5	1226	5	URGCP	7	43917489	Missense_Mutation	SNP	T	TCGA-CV-6950-01A-11D-1912-08	8629055	43917489	115221174	22	37528											
MGC26647	219557	broad.mit.edu	37	chr7	88423535	88423535	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccataccacctcagaatccAgagtgatgtgtatgggtcta	11	10	10	10	0	2	3	1	1	1	2	3	3	3	3	4	1	1	1	4	1	4	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr7:88423535A>G	uc003ujv.2	-	2	904	c.722T>C	c.(721-723)CTG>CCG	p.L241P	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	241											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			CTCAGAATCCAGAGTGATGTG	0.403													15	23					0	0	0	0	G	88423535	G	G	88423535	3	3	205	1	0	0	0	0	1	0	0	0	9603	188	7	5	43	5	MGC26647	7	88423535	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08	44506046	88423535	70715128	23	37529											
AKAP9	10142	broad.mit.edu	37	chr7	91659267	91659267	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagagaacaatgtaccctGgaagttgtgtgaaaaagaat	17	8	10	6	0	0	3	0	1	0	2	0	5	0	4	1	1	2	2	1	1	7	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr7:91659267G>T	uc003ulg.2	+	15	4432	c.4207G>T	c.(4207-4209)GGA>TGA	p.G1403*	AKAP9_uc003ule.2_Nonsense_Mutation_p.G1415*|AKAP9_uc003ulf.2_Nonsense_Mutation_p.G1403*|AKAP9_uc003uli.2_Nonsense_Mutation_p.G1028*	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1415					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AATGTACCCTGGAAGTTGTGT	0.269			T	BRAF	papillary thyroid								47	47					1.39843e-22	3.55777e-22	1	0	T	91659267	T	T	91659267	4	4	205	1	0	0	0	0	0	1	0	0	459	1349	47	4	4265	4	AKAP9	7	91659267	Nonsense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08	3235732	91659267	67479396	24	37530											
C7orf64	84060	broad.mit.edu	37	chr7	92161858	92161858	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtagtaaaaactactgaaaAtaaaggtatggaaagcatat	20	10	8	3	0	0	1	0	1	0	0	0	2	0	2	0	2	3	4	0	2	12	6			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr7:92161858A>G	uc003ulz.2	+	3	484	c.443A>G	c.(442-444)AAT>AGT	p.N148S	C7orf64_uc011khu.1_Missense_Mutation_p.N148S|C7orf64_uc003uma.2_Missense_Mutation_p.N148S	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	148							nucleotide binding			ovary(2)	2						ACTACTGAAAATAAAGGTATG	0.204													22	18					0	0	0	0	G	92161858	G	G	92161858	3	3	205	1	0	0	0	0	1	0	0	0	2421	101	4	5	453	5	C7orf64	7	92161858	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08	502591	92161858	66976805	25	37531											
PXDNL	137902	broad.mit.edu	37	chr8	52320774	52320774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgaatgatggtggcagccGaatccacggccgcagaataa	12	8	12	9	3	0	3	0	2	0	1	1	4	1	3	3	3	1	2	3	3	4	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr8:52320774G>A	uc003xqu.3	-	17	3511	c.3410C>T	c.(3409-3411)TCG>TTG	p.S1137L	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1137					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GGTGGCAGCCGAATCCACGGC	0.522													10	125					0	0	0	0	A	52320774	A	A	52320774	3	1	205	1	0	0	0	0	1	0	0	0	12913	1059	37	1	1009	1	PXDNL	8	52320774	Missense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08		52320774	94043248	26	37532											
PXDNL	137902	broad.mit.edu	37	chr8	52336259	52336259	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgccttcatcatccacatgGaatttaccactctcagtaat	11	13	5	12	0	3	0	3	0	1	0	5	1	4	1	3	1	2	1	3	1	3	4			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr8:52336259G>A	uc003xqu.3	-	14	1772	c.1671C>T	c.(1669-1671)TTC>TTT	p.F557F		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	557	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CATCCACATGGAATTTACCAC	0.433													9	38					0	0	0	0	A	52336259	A	A	52336259	2	1	205	1	0	0	0	0	0	0	0	1	12913	1165	41	2		2	PXDNL	8	52336259	Silent	SNP	G	TCGA-CV-6950-01A-11D-1912-08	15485	52336259	94027763	27	37533											
KIAA1429	25962	broad.mit.edu	37	chr8	95531399	95531399	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtacaacgctgaaaatggCtgaacagttctgtaatacat	14	11	8	8	1	1	2	0	2	1	0	1	2	1	2	0	1	4	5	0	1	7	4			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr8:95531399C>T	uc003ygo.1	-	9	2340	c.2327G>A	c.(2326-2328)AGC>AAC	p.S776N	KIAA1429_uc003ygp.2_Missense_Mutation_p.S776N|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	776					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CTGAAAATGGCTGAACAGTTC	0.423													8	55					0	0	0	0	T	95531399	T	T	95531399	3	4	205	1	0	0	0	0	1	0	0	0	8270	797	28	4	3229	4	KIAA1429	8	95531399	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	43195140	95531399	50832623	28	37534											
UBR5	51366	broad.mit.edu	37	chr8	103287969	103287969	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctccaacatcttccatgaaTaccctgccgaacagttctaa	12	10	5	14	1	2	1	0	1	2	0	4	2	4	1	4	0	4	2	4	0	5	4			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr8:103287969T>A	uc003ykr.1	-	46	6630	c.6597A>T	c.(6595-6597)GTA>GTT	p.V2199V	UBR5_uc003yks.1_Silent_p.V2199V	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2199					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTTCCATGAATACCCTGCCGA	0.423													12	32					0	0	0	0	A	103287969	A	A	103287969	2	1	205	1	0	0	0	0	0	0	0	1	16973	1393	49	5		5	UBR5	8	103287969	Silent	SNP	T	TCGA-CV-6950-01A-11D-1912-08	7756570	103287969	43076053	29	37535											
MTSS1	9788	broad.mit.edu	37	chr8	125597387	125597387	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcttttttatctcttggCgggctttcttatattctaag	6	21	6	8	1	4	0	0	0	4	0	5	0	4	0	0	2	0	1	0	2	4	10			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr8:125597387C>A	uc003yrk.2	-	6	935	c.401G>T	c.(400-402)CGC>CTC	p.R134L	MTSS1_uc003yrj.2_Missense_Mutation_p.R134L|MTSS1_uc003yrl.2_Missense_Mutation_p.R134L	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	134	IMD.|Potential.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TATCTCTTGGCGGGCTTTCTT	0.363													49	115					9.87224e-16	2.47521e-15	1	0	A	125597387	A	A	125597387	3	1	205	1	0	0	0	0	1	0	0	0	10015	768	27	3	1902	3	MTSS1	8	125597387	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	22309418	125597387	20766635	30	37536											
RFX3	5991	broad.mit.edu	37	chr9	3263051	3263051	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attaagcgacgtgtatcttcGcagagtctgggcaaaggcac	11	9	12	9	3	2	1	0	0	2	1	3	2	2	1	0	2	1	4	0	2	3	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr9:3263051G>A	uc003zhr.2	-	14	1801	c.1489C>T	c.(1489-1491)CGA>TGA	p.R497*	RFX3_uc010mhd.2_Nonsense_Mutation_p.R497*|RFX3_uc003zhs.1_Nonsense_Mutation_p.R497*	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	497					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		GTGTATCTTCGCAGAGTCTGG	0.483													23	98					0	0	0	0	A	3263051	A	A	3263051	4	1	205	1	0	0	0	0	0	1	0	0	13329	1095	38	1	936	1	RFX3	9	3263051	Nonsense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08		3263051	137950380	31	37537											
BSPRY	54836	broad.mit.edu	37	chr9	116131934	116131934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcgatgagaggacagtcagcCccttcctgcaattgtcagat	10	10	10	11	1	2	2	2	1	0	2	4	5	3	3	3	1	2	1	3	1	1	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr9:116131934C>T	uc004bhg.3	+	6	769	c.721C>T	c.(721-723)CCC>TCC	p.P241S	BSPRY_uc010muw.2_3'UTR	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	241	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						GACAGTCAGCCCCTTCCTGCA	0.577													14	84					0	0	0	0	T	116131934	T	T	116131934	3	4	205	1	0	0	0	0	1	0	0	0	1537	623	22	4	743	4	BSPRY	9	116131934	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	112868883	116131934	25081497	32	37538											
COL5A1	1289	broad.mit.edu	37	chr9	137676879	137676879	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggggagaagatggccctgaAggcccaaagggtcgcggagg	11	3	19	8	2	0	3	0	1	0	2	1	5	0	4	2	7	0	0	2	7	3	0			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr9:137676879A>C	uc004cfe.2	+	30	2911	c.2529A>C	c.(2527-2529)GAA>GAC	p.E843D		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	843	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ATGGCCCTGAAGGCCCAAAGG	0.622													34	29					0	0	0	0	C	137676879	C	C	137676879	3	2	205	1	0	0	0	0	1	0	0	0	3711	69	3	5	2647	5	COL5A1	9	137676879	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08	21544945	137676879	3536552	33	37539											
SEC16A	9919	broad.mit.edu	37	chr9	139354513	139354513	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtggacgcggcaggcatcCgtccggacatgagctggtag	7	6	16	12	5	0	1	0	1	0	0	2	3	2	3	3	5	1	4	3	5	1	1			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr9:139354513C>T	uc004chx.2	-	14	5363	c.5054G>A	c.(5053-5055)CGG>CAG	p.R1685Q	SEC16A_uc004chu.2_5'Flank|SEC16A_uc004chv.3_Missense_Mutation_p.R1075Q|SEC16A_uc004chw.2_Missense_Mutation_p.R1685Q|SEC16A_uc010nbn.2_Missense_Mutation_p.R1685Q	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1507					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GGCAGGCATCCGTCCGGACAT	0.592													11	8					0	0	0	0	T	139354513	T	T	139354513	3	4	205	1	0	0	0	0	1	0	0	0	14051	652	23	1	2095	1	SEC16A	9	139354513	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	1677634	139354513	1858918	34	37540											
TALDO1	6888	broad.mit.edu	37	chr11	755976	755976	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggagctggtggaggaggcGattgcctatggccggaagct	8	7	18	8	2	0	0	0	0	0	0	0	5	0	4	2	7	3	2	2	7	2	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr11:755976G>A	uc001lqz.2	+	2	245	c.195G>A	c.(193-195)GCG>GCA	p.A65A	TALDO1_uc010qwl.1_Silent_p.A65A|TALDO1_uc001lra.2_Silent_p.A65A	NM_006755	NP_006746	P37837	TALDO_HUMAN	transaldolase 1	65					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		TGGAGGAGGCGATTGCCTATG	0.632													4	27					0	0	0	0	A	755976	A	A	755976	2	1	205	1	0	0	0	0	0	0	0	1	15609	1045	37	1		1	TALDO1	11	755976	Silent	SNP	G	TCGA-CV-6950-01A-11D-1912-08		755976	134250540	35	37541											
SPRYD5	84767	broad.mit.edu	37	chr11	55658941	55658943	+	In_Frame_Del	DEL	GTG	-	-																															tctttaccacctccccacttGtggtgcaatatgttccaaga																										TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr11:55658941_55658943delGTG	uc010rip.1	+	7	1284_1286	c.1192_1194delGTG	c.(1192-1194)GTGdel	p.V399del	SPRYD5_uc010riq.1_In_Frame_Del_p.V256del	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	399	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CTCCCCACTTGTGGTGCAATATG	0.448													---	---	---								-	55658943	-	-	55658941	7	5	205	1	0	1	0	1	0	0	0	0	15177	1377	48	0	1214	0	SPRYD5	11	55658941	In_Frame_Del	DEL	GTG	TCGA-CV-6950-01A-11D-1912-08	54902965	55658941	79347575	36	37542											
ATM	472	broad.mit.edu	37	chr11	108206667	108206667	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acggaaactaggaagaggaaAttaactatctgtacttataa	18	10	8	5	1	1	1	0	0	1	1	1	4	1	4	0	3	3	1	0	3	9	6			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr11:108206667A>C	uc001pkb.1	+	56	8632	c.8247A>C	c.(8245-8247)AAA>AAC	p.K2749N	ATM_uc009yxr.1_Missense_Mutation_p.K2749N|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.K1401N	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2749	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GGAAGAGGAAATTAACTATCT	0.328			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			15	13					0	0	0	0	C	108206667	C	C	108206667	3	2	205	1	0	0	0	0	1	0	0	0	1111	98	4	5	8465	5	ATM	11	108206667	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08	52547726	108206667	26799849	37	37543											
C3AR1	719	broad.mit.edu	37	chr12	8212707	8212707	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggctgagaatgaccatggaGagaattactgggggctcatt	12	9	14	6	0	1	3	1	2	0	2	1	6	1	4	1	4	1	2	1	4	3	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr12:8212707G>A	uc001qtv.1	-	2	167	c.75C>T	c.(73-75)CTC>CTT	p.L25L		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	25	Helical; Name=1; (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		TGACCATGGAGAGAATTACTG	0.488													30	68					0	0	0	0	A	8212707	A	A	8212707	2	1	205	1	0	0	0	0	0	0	0	1	2215	929	33	2		2	C3AR1	12	8212707	Silent	SNP	G	TCGA-CV-6950-01A-11D-1912-08		8212707	125639188	38	37544											
MLL2	8085	broad.mit.edu	37	chr12	49444269	49444276	+	Frame_Shift_Del	DEL	GGGAACCA	-	-																															tgggaaggaggggagttttgGggaaccagggaatgctgaag																										TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr12:49444269_49444276delGGGAACCA	uc001rta.3	-	11	3095_3102	c.3095_3102delTGGTTCCC	c.(3094-3102)CTGGTTCCCfs	p.L1032fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1032_1034	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGGAGTTTTGGGGAACCAGGGAATGCTG	0.611			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								-	49444276	-	-	49444269	7	5	205	1	0	1	0	1	0	0	0	0	9674	1219	43	0	13687	0	MLL2	12	49444269	Frame_Shift_Del	DEL	GGGAACCA	TCGA-CV-6950-01A-11D-1912-08	41231562	49444269	84407626	39	37545											
CUX2	23316	broad.mit.edu	37	chr12	111758147	111758147	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccgcaaggtcaagtccgaGatcggcgacgccggctactt	9	7	12	13	6	1	1	1	0	0	1	4	3	3	1	3	3	1	2	3	3	3	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr12:111758147G>T	uc001tsa.1	+	17	2487	c.2334G>T	c.(2332-2334)GAG>GAT	p.E778D		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	778						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TCAAGTCCGAGATCGGCGACG	0.721													18	39					5.3912e-06	1.16585e-05	1	0	T	111758147	T	T	111758147	3	4	205	1	0	0	0	0	1	0	0	0	4082	933	33	2	2400	2	CUX2	12	111758147	Missense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08	62313878	111758147	22093748	40	37546											
GTF3A	2971	broad.mit.edu	37	chr13	28004707	28004707	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagaagacctttaagaaacAtcagcagctgaaaatccatc	18	8	6	9	0	1	4	1	1	0	3	3	4	2	4	2	0	3	2	2	0	6	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr13:28004707A>T	uc001ure.2	+	4	631	c.437A>T	c.(436-438)CAT>CTT	p.H146L	GTF3A_uc001urf.2_5'UTR|GTF3A_uc001urg.2_RNA	NM_002097	NP_002088	Q92664	TF3A_HUMAN	transcription factor IIIA	146	C2H2-type 4; atypical.				regulation of transcription, DNA-dependent|rRNA transcription|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|protein binding|RNA binding|zinc ion binding				0		Lung SC(185;0.0156)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.11)|OV - Ovarian serous cystadenocarcinoma(117;0.158)		TTTAAGAAACATCAGCAGCTG	0.383													9	9					0	0	0	0	T	28004707	T	T	28004707	3	4	205	1	0	0	0	0	1	0	0	0	6910	217	8	5	451	5	GTF3A	13	28004707	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08		28004707	87165171	41	37547											
MYCBP2	23077	broad.mit.edu	37	chr13	77662989	77662989	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatagcaaaaactcgacaaGcagatttccttagggcctgt	13	9	8	11	1	0	1	0	0	0	1	2	2	1	1	3	1	3	2	3	1	5	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr13:77662989G>A	uc001vkf.2	-	62	10680	c.10589C>T	c.(10588-10590)GCT>GTT	p.A3530V	MYCBP2_uc010aev.2_Missense_Mutation_p.A2934V|MYCBP2_uc001vke.2_Missense_Mutation_p.A150V	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3530					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AACTCGACAAGCAGATTTCCT	0.353													17	20					0	0	0	0	A	77662989	A	A	77662989	3	1	205	1	0	0	0	0	1	0	0	0	10071	971	34	4	3425	4	MYCBP2	13	77662989	Missense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08	49658282	77662989	37506889	42	37548											
JUB	84962	broad.mit.edu	37	chr14	23447604	23447604	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagaggctgtccagggcctGgcaggcattgctctgcccat	6	9	14	12	0	1	1	0	0	1	1	2	1	2	1	3	4	2	5	3	4	1	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr14:23447604G>A	uc001whz.2	-	2	1433	c.1057C>T	c.(1057-1059)CAG>TAG	p.Q353*	JUB_uc001why.2_5'Flank	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	353	LIM zinc-binding 1.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		TCCAGGGCCTGGCAGGCATTG	0.542													124	49					0	0	0	0	A	23447604	A	A	23447604	4	1	205	1	0	0	0	0	0	1	0	0	8007	1357	47	4	587	4	JUB	14	23447604	Nonsense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08		23447604	83901936	43	37549											
TM9SF1	10548	broad.mit.edu	37	chr14	24679887	24679887	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acatcatctccaaagcccatAggccgagaaatggcatctga	14	7	8	12	1	3	2	1	1	2	1	4	3	3	2	3	2	1	1	3	2	3	1			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr14:24679887A>G	uc010tob.1	-	4	1159	c.525T>C	c.(523-525)CCT>CCC	p.P175P	CHMP4A_uc001wni.2_Silent_p.P192P|CHMP4A_uc010toc.1_RNA|CHMP4A_uc001wnj.2_Silent_p.P192P	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	Error:Variant_position_missing_in_O15321_after_alignment					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		CAAAGCCCATAGGCCGAGAAA	0.507													3	152					0	0	0	0	G	24679887	G	G	24679887	2	3	205	1	0	0	0	0	0	0	0	1	16043	407	15	5		5	TM9SF1	14	24679887	Silent	SNP	A	TCGA-CV-6950-01A-11D-1912-08	1232283	24679887	82669653	44	37550											
SOS2	6655	broad.mit.edu	37	chr14	50597456	50597456	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggccttattccaggagattTtaaggaaaaagttgatttcc	13	13	9	6	0	0	2	0	1	0	1	2	4	2	3	3	3	0	1	3	3	4	6			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr14:50597456T>C	uc001wxs.3	-	20	3198	c.3100A>G	c.(3100-3102)AAA>GAA	p.K1034E	SOS2_uc010ans.2_5'UTR|SOS2_uc010tql.1_Missense_Mutation_p.K1001E	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1034					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					CCAGGAGATTTTAAGGAAAAA	0.383													6	56					0	0	0	0	C	50597456	C	C	50597456	3	2	205	1	0	0	0	0	1	0	0	0	15001	1850	64	5	914	5	SOS2	14	50597456	Missense_Mutation	SNP	T	TCGA-CV-6950-01A-11D-1912-08	25917569	50597456	56752084	45	37551											
EML5	161436	broad.mit.edu	37	chr14	89091394	89091394	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaggcccgttgtgagctctCgccacgattctacacaatat	10	10	8	13	3	2	1	0	1	2	0	3	2	2	1	2	1	2	2	2	1	3	4			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr14:89091394C>T	uc001xxg.2	-	36	5004	c.4818G>A	c.(4816-4818)GCG>GCA	p.A1606A	EML5_uc001xxf.2_Silent_p.A393A|EML5_uc001xxh.1_Silent_p.A737A	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1598	WD 23.					cytoplasm|microtubule				ovary(3)	3						TGTGAGCTCTCGCCACGATTC	0.502													6	67					0	0	0	0	T	89091394	T	T	89091394	2	4	205	1	0	0	0	0	0	0	0	1	5124	871	31	1		1	EML5	14	89091394	Silent	SNP	C	TCGA-CV-6950-01A-11D-1912-08	38493938	89091394	18258146	46	37552											
KLC1	3831	broad.mit.edu	37	chr14	104167058	104167058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggcctggaagacgccacCgctaacgtgagtcccacggc	9	5	13	14	4	0	2	0	1	0	1	1	3	1	3	4	3	1	1	4	3	2	1			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr14:104167058C>T	uc001yno.2	+	14	2025	c.1717C>T	c.(1717-1719)CGC>TGC	p.R573C	KLC1_uc010tyf.1_Silent_p.T616T|KLC1_uc001yns.2_RNA|XRCC3_uc001yny.3_Intron|XRCC3_uc001ynx.3_Intron|XRCC3_uc001ynz.3_Intron|XRCC3_uc001yoa.3_Intron	NM_182923	NP_891553	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 2	573					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				AAGACGCCACCGCTAACGTGA	0.627													11	70					0	0	0	0	T	104167058	T	T	104167058	3	4	205	1	0	0	0	0	1	0	0	0	8372	652	23	1	1939	1	KLC1	14	104167058	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	15075664	104167058	3182482	47	37553											
HERC2	8924	broad.mit.edu	37	chr15	28467346	28467346	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattcatatcttcctcaacgTtgtcacaactggggcctgat	9	13	7	12	1	4	1	3	1	1	0	5	1	5	1	2	2	2	1	2	2	3	4			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr15:28467346T>C	uc001zbj.2	-	36	5586	c.5480A>G	c.(5479-5481)AAC>AGC	p.N1827S		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1827					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTCCTCAACGTTGTCACAACT	0.458													9	29					0	0	0	0	C	28467346	C	C	28467346	3	2	205	1	0	0	0	0	1	0	0	0	7097	1725	60	5	9256	5	HERC2	15	28467346	Missense_Mutation	SNP	T	TCGA-CV-6950-01A-11D-1912-08		28467346	74064046	48	37554											
ACTC1	70	broad.mit.edu	37	chr15	35082732	35082732	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcccccaatccagacagagtAtttacgctcagggggagcaa	12	6	11	12	1	1	2	1	0	0	2	2	3	2	3	3	2	2	3	3	2	4	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr15:35082732A>G	uc001ziu.1	-	7	1258	c.1015T>C	c.(1015-1017)TAC>CAC	p.Y339H	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	339					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		CAGACAGAGTATTTACGCTCA	0.478													21	69					0	0	0	0	G	35082732	G	G	35082732	3	3	205	1	0	0	0	0	1	0	0	0	195	449	16	5	122	5	ACTC1	15	35082732	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08	6615386	35082732	67448660	49	37555											
PKD1	5310	broad.mit.edu	37	chr16	2160250	2160250	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggggaagtagcggccacCgcccaccacctgcagcccct	7	4	13	17	2	0	0	0	0	0	0	0	1	0	1	7	4	3	2	7	4	2	1			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr16:2160250C>G	uc002cos.1	-	15	5127	c.4918G>C	c.(4918-4920)GGT>CGT	p.G1640R	PKD1_uc002cot.1_Missense_Mutation_p.G1640R	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1640	Extracellular (Potential).|PKD 12.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TAGCGGCCACCGCCCACCACC	0.617													19	13					0	0	0	0	G	2160250	G	G	2160250	3	3	205	1	0	0	0	0	1	0	0	0	12018	652	23	3	8121	3	PKD1	16	2160250	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08		2160250	88194503	50	37556											
TAOK2	9344	broad.mit.edu	37	chr16	30002124	30002124	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcggcttgatgagacccAggaggcagagttccaggccc	8	6	15	12	1	0	3	0	2	0	2	1	5	1	4	3	4	1	4	3	4	0	2	rs140227077		TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr16:30002124A>G	uc002dvc.1	+	18	3248	c.2465A>G	c.(2464-2466)CAG>CGG	p.Q822R	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron	NM_004783	NP_004774	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GATGAGACCCAGGAGGCAGAG	0.612													18	34					0	0	0	0	G	30002124	G	G	30002124	3	3	205	1	0	0	0	0	1	0	0	0	15614	188	7	5	4007	5	TAOK2	16	30002124	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08	27841874	30002124	60352629	51	37557											
TP53	7157	broad.mit.edu	37	chr17	7578241	7578241	+	Frame_Shift_Del	DEL	A	-	-																															ttctgtcatccaaatactccAcacgcaaatttccttccact																										TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr17:7578241delA	uc002gim.2	-	6	802	c.608delT	c.(607-609)GTGfs	p.V203fs	TP53_uc002gig.1_Frame_Shift_Del_p.V203fs|TP53_uc002gih.2_Frame_Shift_Del_p.V203fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.V71fs|TP53_uc010cng.1_Frame_Shift_Del_p.V71fs|TP53_uc002gii.1_Frame_Shift_Del_p.V71fs|TP53_uc010cnh.1_Frame_Shift_Del_p.V203fs|TP53_uc010cni.1_Frame_Shift_Del_p.V203fs|TP53_uc002gij.2_Frame_Shift_Del_p.V203fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.V110fs|TP53_uc002gio.2_Frame_Shift_Del_p.V71fs|TP53_uc010vug.1_Frame_Shift_Del_p.V164fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	203	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		VE -> LV (in a sporadic cancer; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.V203E(6)|p.V203L(3)|p.V203fs*44(3)|p.V203V(3)|p.V203fs*6(2)|p.V203M(2)|p.K164_P219del(1)|p.N200fs*4(1)|p.V203A(1)|p.E204fs*5(1)|p.V203_E204>V*(1)|p.V203_E204>LV(1)|p.G199fs*42(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAATACTCCACACGCAAATT	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578241	-	-	7578241	7	5	205	1	0	1	0	1	0	0	0	0	16448	159	6	0	686	0	TP53	17	7578241	Frame_Shift_Del	DEL	A	TCGA-CV-6950-01A-11D-1912-08		7578241	73616969	52	37558											
ACACA	31	broad.mit.edu	37	chr17	35620680	35620680	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgttgtacagagcaatcacGaccaaacaaagagatagcat	17	6	9	9	2	1	2	1	0	0	2	1	4	1	2	1	0	4	4	1	0	5	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr17:35620680G>A	uc002hnm.2	-	11	1317	c.1126C>T	c.(1126-1128)CGT>TGT	p.R376C	ACACA_uc002hnk.2_Missense_Mutation_p.R298C|ACACA_uc002hnl.2_Missense_Mutation_p.R318C|ACACA_uc002hnn.2_Missense_Mutation_p.R376C|ACACA_uc002hno.2_Missense_Mutation_p.R413C|ACACA_uc010cuz.2_Missense_Mutation_p.R376C	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	376	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GAGCAATCACGACCAAACAAA	0.433													19	180					0	0	0	0	A	35620680	A	A	35620680	3	1	205	1	0	0	0	0	1	0	0	0	106	1058	37	1	6098	1	ACACA	17	35620680	Missense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08	28042439	35620680	45574530	53	37559											
PSME3	10197	broad.mit.edu	37	chr17	40986550	40986550	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggcagaagacttggtggcaAattttttcccaaagaagtta	14	11	10	6	0	0	3	0	0	0	3	1	3	1	3	1	3	0	3	1	3	5	5			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr17:40986550A>G	uc002ibr.2	+	3	320	c.94A>G	c.(94-96)AAT>GAT	p.N32D	PSME3_uc002ibp.2_5'UTR|PSME3_uc002ibq.2_Missense_Mutation_p.N32D|PSME3_uc002ibs.2_Missense_Mutation_p.N43D|PSME3_uc010whd.1_5'UTR	NM_005789	NP_005780	P61289	PSME3_HUMAN	proteasome activator subunit 3 isoform 1	32					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome activator complex	endopeptidase activator activity|identical protein binding|MDM2 binding|p53 binding				0		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		CTTGGTGGCAAATTTTTTCCC	0.328													33	86					0	0	0	0	G	40986550	G	G	40986550	3	3	205	1	0	0	0	0	1	0	0	0	12770	14	1	5	104	5	PSME3	17	40986550	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08	5365870	40986550	40208660	54	37560											
RTTN	25914	broad.mit.edu	37	chr18	67801778	67801778	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tattggaaggattaacagacCtatttcataaaagaaaaaca	20	10	6	5	0	1	2	1	0	0	2	1	4	1	4	1	2	2	0	1	2	8	6			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr18:67801778C>T	uc002lkp.2	-	23	2954	c.2886_splice	c.e23-1	p.W962_splice	RTTN_uc002lko.2_Splice_Site|RTTN_uc010xfb.1_Splice_Site_p.W50_splice	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin								binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				ATTAACAGACCTATTTCATAA	0.333													4	31					0	0	0	0	T	67801778	T	T	67801778	5	4	205	1	0	0	0	0	0	0	1	0	13802	695	24	4	3903	4	RTTN	18	67801778	Splice_Site	SNP	C	TCGA-CV-6950-01A-11D-1912-08		67801778	10275470	55	37561											
SAFB2	9667	broad.mit.edu	37	chr19	5604923	5604923	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccccgggctgcgggcgtTcgttaccactttggccccga	4	8	13	16	5	0	0	0	0	0	0	1	1	0	0	5	3	3	3	5	3	1	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr19:5604923T>C	uc002mcd.2	-	10	1533	c.1321A>G	c.(1321-1323)AAC>GAC	p.N441D		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	441	RRM.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		CTGCGGGCGTTCGTTACCACT	0.517													7	47					0	0	0	0	C	5604923	C	C	5604923	3	2	205	1	0	0	0	0	1	0	0	0	13872	1783	62	5	1588	5	SAFB2	19	5604923	Missense_Mutation	SNP	T	TCGA-CV-6950-01A-11D-1912-08		5604923	53524060	56	37562											
S1PR5	53637	broad.mit.edu	37	chr19	10624909	10624909	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggggccccaacatgccacaAaggccaggagcaccacgctg	11	2	13	15	1	0	0	0	0	0	0	0	1	0	1	5	4	3	2	5	4	2	0			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr19:10624909A>T	uc002mot.1	-	2	836	c.779T>A	c.(778-780)TTT>TAT	p.F260Y	S1PR5_uc002mou.1_Missense_Mutation_p.F260Y	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	260	Helical; Name=6; (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						ACATGCCACAAAGGCCAGGAG	0.716													7	4					0	0	0	0	T	10624909	T	T	10624909	3	4	205	1	0	0	0	0	1	0	0	0	13862	14	1	5	421	5	S1PR5	19	10624909	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08	5019986	10624909	48504074	57	37563											
ZNF574	64763	broad.mit.edu	37	chr19	42584699	42584699	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggggctgccttcccctcCtcactgcggctccgggagca	3	9	13	16	2	1	0	1	0	0	0	4	1	4	1	5	4	3	3	5	4	0	1			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr19:42584699C>T	uc002osm.3	+	2	2110	c.1941C>T	c.(1939-1941)TCC>TCT	p.S647S	ZNF574_uc002osk.3_Silent_p.S737S	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	647	C2H2-type 15; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CCTTCCCCTCCTCACTGCGGC	0.697													16	64					0	0	0	0	T	42584699	T	T	42584699	2	4	205	1	0	0	0	0	0	0	0	1	18073	668	24	4		4	ZNF574	19	42584699	Silent	SNP	C	TCGA-CV-6950-01A-11D-1912-08	31959790	42584699	16544284	58	37564											
IRGQ	126298	broad.mit.edu	37	chr19	44097383	44097383	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacggccaggtctagccgtgCgctgcccaggcgctccaggc	5	5	14	17	4	1	0	0	0	1	0	2	0	2	0	4	4	3	2	4	4	1	1			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr19:44097383C>T	uc002oww.2	-	2	785	c.667G>A	c.(667-669)GCA>ACA	p.A223T	IRGQ_uc010eiv.2_Missense_Mutation_p.A223T	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	223							protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				TCTAGCCGTGCGCTGCCCAGG	0.682													22	46					0	0	0	0	T	44097383	T	T	44097383	3	4	205	1	0	0	0	0	1	0	0	0	7878	768	27	1	1208	1	IRGQ	19	44097383	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	1512684	44097383	15031600	59	37565											
LILRB1	10859	broad.mit.edu	37	chr19	55144748	55144748	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctgactcaccccagtgacCccctggagctcgtggtctca	6	9	10	16	1	2	2	2	2	1	0	4	3	2	3	4	2	2	2	4	2	0	0			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr19:55144748C>G	uc002qgj.2	+	8	1580	c.1240C>G	c.(1240-1242)CCC>GCC	p.P414A	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.P414A|LILRB1_uc002qgk.2_Missense_Mutation_p.P414A|LILRB1_uc002qgm.2_Missense_Mutation_p.P414A|LILRB1_uc010erq.2_Missense_Mutation_p.P414A|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	414	Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CCCCAGTGACCCCCTGGAGCT	0.622										HNSCC(37;0.09)			3	78					0	0	0	0	G	55144748	G	G	55144748	3	3	205	1	0	0	0	0	1	0	0	0	8831	623	22	4	1262	4	LILRB1	19	55144748	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	11047365	55144748	3984235	60	37566											
CHGB	1114	broad.mit.edu	37	chr20	5903296	5903296	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggatgaggaggaggaggAgggagagaactatcaaaaag	18	3	18	2	0	1	3	1	1	0	2	1	10	1	9	0	6	1	0	0	6	4	1			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr20:5903296A>G	uc002wmg.2	+	4	812	c.506A>G	c.(505-507)GAG>GGG	p.E169G	CHGB_uc010zqz.1_5'UTR	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	169	Poly-Glu.					extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GAGGAGGAGGAGGGAGAGAAC	0.512													3	47					0	0	0	0	G	5903296	G	G	5903296	3	3	205	1	0	0	0	0	1	0	0	0	3354	304	11	5	520	5	CHGB	20	5903296	Missense_Mutation	SNP	A	TCGA-CV-6950-01A-11D-1912-08		5903296	57122224	61	37567											
FOXS1	2307	broad.mit.edu	37	chr20	30433105	30433105	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctggcttgcggtcatcgcGgggcaccttgacaaagcact	7	8	13	13	3	1	1	1	1	0	0	2	1	1	1	2	4	2	3	2	4	1	2			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr20:30433105G>T	uc002wwt.1	-	1	316	c.241C>A	c.(241-243)CGC>AGC	p.R81S		NM_004118	NP_004109	O43638	FOXS1_HUMAN	forkhead box S1	81	Fork-head.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1						CGGTCATCGCGGGGCACCTTG	0.637													17	62					6.49762e-13	1.60584e-12	1	0	T	30433105	T	T	30433105	3	4	205	1	0	0	0	0	1	0	0	0	6069	1116	39	3	755	3	FOXS1	20	30433105	Missense_Mutation	SNP	G	TCGA-CV-6950-01A-11D-1912-08	24529809	30433105	32592415	62	37568											
GSS	2937	broad.mit.edu	37	chr20	33519179	33519179	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttagcacaaaccggctaggGgcagcaagggcctcggcgat	10	6	14	11	3	0	0	0	0	0	0	1	1	0	0	2	5	3	4	2	5	4	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr20:33519179G>A	uc002xbg.2	-	11	1151	c.1071C>T	c.(1069-1071)GCC>GCT	p.A357A	GSS_uc010zun.1_Silent_p.A229A|GSS_uc010zuo.1_Silent_p.A246A|GSS_uc010zup.1_Silent_p.A288A|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_Silent_p.A87A	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	357					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	ACCGGCTAGGGGCAGCAAGGG	0.562													9	33					0	0	0	0	A	33519179	A	A	33519179	2	1	205	1	0	0	0	0	0	0	0	1	6868	1219	43	4		4	GSS	20	33519179	Silent	SNP	G	TCGA-CV-6950-01A-11D-1912-08	3086074	33519179	29506341	63	37569											
CABIN1	23523	broad.mit.edu	37	chr22	24439496	24439496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgcaatcctgaccactggcCctgtttggataacctaatca	10	11	8	12	0	1	1	1	1	0	0	2	2	2	2	4	2	2	2	4	2	3	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr22:24439496C>T	uc002zzi.1	+	6	603	c.476C>T	c.(475-477)CCC>CTC	p.P159L	CABIN1_uc002zzj.1_Missense_Mutation_p.P159L|CABIN1_uc002zzl.1_Missense_Mutation_p.P159L|CABIN1_uc010guk.1_Missense_Mutation_p.P114L|CABIN1_uc002zzk.1_Missense_Mutation_p.P114L	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	159					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GACCACTGGCCCTGTTTGGAT	0.512													15	83					0	0	0	0	T	24439496	T	T	24439496	3	4	205	1	0	0	0	0	1	0	0	0	2540	623	22	4	494	4	CABIN1	22	24439496	Missense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08		24439496	26865070	64	37570											
MYO18B	84700	broad.mit.edu	37	chr22	26164180	26164180	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgaccagtcaagctctccTgggagctcagacattctggg	9	8	12	12	1	4	1	2	0	2	1	5	4	4	2	2	2	2	2	2	2	1	1			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chr22:26164180T>C	uc003abz.1	+	4	547	c.297T>C	c.(295-297)CCT>CCC	p.P99P	MYO18B_uc003aca.1_5'UTR|MYO18B_uc010guy.1_5'UTR|MYO18B_uc010guz.1_5'UTR|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	99	Ser-rich.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CAAGCTCTCCTGGGAGCTCAG	0.582													16	136					0	0	0	0	C	26164180	C	C	26164180	2	2	205	1	0	0	0	0	0	0	0	1	10119	1567	55	5		5	MYO18B	22	26164180	Silent	SNP	T	TCGA-CV-6950-01A-11D-1912-08	1724684	26164180	25140386	65	37571											
MXRA5	25878	broad.mit.edu	37	chrX	3241944	3241944	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcattgcaaggcaatgtcacCgactcccctgggttcttgcc	7	10	10	14	1	2	0	1	0	1	0	3	1	3	0	4	2	2	4	4	2	2	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chrX:3241944C>T	uc004crg.3	-	5	1939	c.1782G>A	c.(1780-1782)TCG>TCA	p.S594S		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	594	Ig-like C2-type 2.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCAATGTCACCGACTCCCCTG	0.473													5	14					0	0	0	0	T	3241944	T	T	3241944	2	4	205	1	0	0	0	0	0	0	0	1	10056	639	23	1		1	MXRA5	23	3241944	Silent	SNP	C	TCGA-CV-6950-01A-11D-1912-08		3241944	152028616	66	37572											
GUCY2F	2986	broad.mit.edu	37	chrX	108718934	108718934	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttgattcgctcaatggctaAtcgcgcagcaacctcaggca	10	9	10	12	3	2	1	2	1	0	0	4	1	2	1	1	2	2	6	1	2	3	3			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chrX:108718934A>G	uc004eod.3	-	2	508	c.232T>C	c.(232-234)TTA>CTA	p.L78L	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	78	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TCAATGGCTAATCGCGCAGCA	0.527											OREG0019905	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	17					0	0	0	0	G	108718934	G	G	108718934	2	3	205	1	0	0	0	0	0	0	0	1	6937	98	4	5		5	GUCY2F	23	108718934	Silent	SNP	A	TCGA-CV-6950-01A-11D-1912-08	105476990	108718934	46551626	67	37573											
ATP11C	286410	broad.mit.edu	37	chrX	138832233	138832233	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcaatgttgatgtgctgttCcagtagactataggccagga	10	12	12	7	0	1	2	1	1	0	1	2	3	2	3	2	2	1	4	2	2	4	5			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chrX:138832233C>A	uc004faz.2	-	24	2887	c.2788G>T	c.(2788-2790)GAA>TAA	p.E930*	ATP11C_uc004fax.2_Nonsense_Mutation_p.E138*|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Nonsense_Mutation_p.E930*	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	930	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					ATGTGCTGTTCCAGTAGACTA	0.393													5	59					1.23904e-05	2.61407e-05	1	0	A	138832233	A	A	138832233	4	1	205	1	0	0	0	0	0	1	0	0	1123	864	30	2	701	2	ATP11C	23	138832233	Nonsense_Mutation	SNP	C	TCGA-CV-6950-01A-11D-1912-08	30113299	138832233	16438327	68	37574											
ARHGAP4	393	broad.mit.edu	37	chrX	153186904	153186904	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctcactcagggccgcgcTctcccggctctgctgccgcg	3	7	11	20	5	4	0	2	0	2	0	5	0	4	0	4	2	2	3	4	2	0	0			TCGA-CV-6950-01A-11D-1912-08	TCGA-CV-6950-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	4a341860-44fb-493e-bd46-aeb6610842de	a6b12650-683a-4397-9098-f44def6bca1f	g.chrX:153186904T>A	uc004fjk.1	-	3	391	c.349A>T	c.(349-351)AGC>TGC	p.S117C	ARHGAP4_uc011mzf.1_Missense_Mutation_p.S94C|ARHGAP4_uc004fjl.1_Missense_Mutation_p.S117C|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	117					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGGCCGCGCTCTCCCGGCTC	0.692													7	7					0	0	0	0	A	153186904	A	A	153186904	3	1	205	1	0	0	0	0	1	0	0	0	885	1551	54	5	2695	5	ARHGAP4	23	153186904	Missense_Mutation	SNP	T	TCGA-CV-6950-01A-11D-1912-08	14354671	153186904	2083656	69	37575											
CLCNKA	1187	broad.mit.edu	37	chr1	16358754	16358754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agctggtgcaggccctccagGctgagcctccttccagggct	5	8	13	15	0	0	1	0	1	0	0	3	1	3	1	5	4	3	4	5	4	0	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:16358754G>A	uc001axu.2	+	17	1893	c.1813G>A	c.(1813-1815)GCT>ACT	p.A605T	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.A605T|CLCNKA_uc010obw.1_Missense_Mutation_p.A562T|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010oby.1_3'UTR	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	605	CBS 1.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	GGCCCTCCAGGCTGAGCCTCC	0.652													17	15					0	0	0	0	A	16358754	A	A	16358754	3	1	206	1	0	0	0	0	1	0	0	0	3484	1203	42	4	1875	4	CLCNKA	1	16358754	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08		16358754	232891867	1	37576											
MAP3K6	9064	broad.mit.edu	37	chr1	27686819	27686819	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgttcttgtggcgcaggcGtctgtgaagagcgatctctt	6	14	13	8	3	3	2	0	1	3	1	4	3	3	2	0	2	1	2	0	2	2	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:27686819G>A	uc001bny.1	-	16	2344	c.2095C>T	c.(2095-2097)CGC>TGC	p.R699C	MAP3K6_uc009vsw.1_Missense_Mutation_p.R691C|MAP3K6_uc001bnz.1_Missense_Mutation_p.R222C	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	699	Protein kinase.				activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TGGCGCAGGCGTCTGTGAAGA	0.592													9	40					0	0	0	0	A	27686819	A	A	27686819	3	1	206	1	0	0	0	0	1	0	0	0	9307	1145	40	1	1827	1	MAP3K6	1	27686819	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	11328065	27686819	221563802	2	37577											
ZBTB8OS	339487	broad.mit.edu	37	chr1	33116074	33116074	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcggatacttggccttgatCgccttctgttcttcagtcaa	6	14	10	11	2	4	1	2	1	2	0	5	2	4	2	2	3	1	1	2	3	2	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:33116074C>T	uc001bvp.2	-	1	112	c.93G>A	c.(91-93)GCG>GCA	p.A31A	ZBTB8OS_uc001bvo.1_RNA|ZBTB8OS_uc001bvq.2_Silent_p.A19A|RBBP4_uc001bvr.2_5'Flank|RBBP4_uc001bvs.2_5'Flank|RBBP4_uc010ohj.1_5'Flank|RBBP4_uc010ohk.1_5'Flank	NM_178547	NP_848642	Q8IWT0	ARCH_HUMAN	zinc finger and BTB domain containing 8 opposite	19											0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGGCCTTGATCGCCTTCTGTT	0.483													39	74					0	0	0	0	T	33116074	T	T	33116074	2	4	206	1	0	0	0	0	0	0	0	1	17624	871	31	1		1	ZBTB8OS	1	33116074	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	5429255	33116074	216134547	3	37578											
ZMYM6	9204	broad.mit.edu	37	chr1	35452858	35452858	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaacagttgaaaagggtaaTaaaaatttcattgccctttc	16	13	6	6	0	1	1	1	1	0	0	2	1	1	1	1	1	2	2	1	1	8	7			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:35452858T>C	uc001byh.2	-	16	4053	c.3825A>G	c.(3823-3825)TTA>TTG	p.L1275L	uc001byd.3_5'Flank|uc001bye.2_5'Flank|ZMYM6_uc001byf.1_Intron|ZMYM6_uc010oht.1_Silent_p.L1178L	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	1275					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				AAAAGGGTAATAAAAATTTCA	0.368													11	40					0	0	0	0	C	35452858	C	C	35452858	2	2	206	1	0	0	0	0	0	0	0	1	17771	1403	49	5		5	ZMYM6	1	35452858	Silent	SNP	T	TCGA-CV-6951-01A-11D-1912-08	2336784	35452858	213797763	4	37579											
TFAP2E	339488	broad.mit.edu	37	chr1	36039988	36039988	+	Frame_Shift_Del	DEL	C	-	-																															ccttccggggctggcggcggCccccggtctggaggacctgc																										TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:36039988delC	uc010ohy.1	+	2	696	c.488delC	c.(487-489)GCCfs	p.A163fs	PSMB2_uc001bzd.1_3'UTR	NM_178548	NP_848643	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating	163						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CTGGCGGCGGCCCCCGGTCTG	0.711													---	---	---								-	36039988	-	-	36039988	7	5	206	1	0	1	0	1	0	0	0	0	15857	739	26	0	494	0	TFAP2E	1	36039988	Frame_Shift_Del	DEL	C	TCGA-CV-6951-01A-11D-1912-08	587130	36039988	213210633	5	37580											
C1orf175	374977	broad.mit.edu	37	chr1	55145695	55145695	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggttgtggtggccctgctCatgtgccccctcccactgaa	5	10	12	14	0	1	1	1	1	0	0	2	2	2	1	4	3	2	2	4	3	1	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:55145695C>T	uc010ooe.1	+	13	2682	c.2358C>T	c.(2356-2358)CTC>CTT	p.L786L	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Silent_p.L354L|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Silent_p.L304L|C1orf175_uc010oof.1_Intron|C1orf175_uc001cxr.1_Intron|C1orf175_uc010oog.1_Silent_p.L786L|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_5'Flank	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	786	Helical; (Potential).					integral to membrane	binding				0						TGGCCCTGCTCATGTGCCCCC	0.647													60	68					0	0	0	0	T	55145695	T	T	55145695	2	4	206	1	0	0	0	0	0	0	0	1	2025	813	29	2		2	C1orf175	1	55145695	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	19105707	55145695	194104926	6	37581											
SLC35D1	23169	broad.mit.edu	37	chr1	67516168	67516168	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggatggagaaccttctcaGaactgtaaacattggcaagc	14	8	10	9	0	1	2	1	0	1	2	2	4	1	3	1	3	4	2	1	3	5	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:67516168G>A	uc001ddk.2	-	5	796	c.412C>T	c.(412-414)CTG>TTG	p.L138L	SLC35D1_uc010oph.1_Silent_p.L59L	NM_015139	NP_055954	Q9NTN3	S35D1_HUMAN	solute carrier family 35 (UDP-glucuronic	138					chondroitin sulfate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity				0					Lorazepam(DB00186)	AACCTTCTCAGAACTGTAAAC	0.294													10	24					0	0	0	0	A	67516168	A	A	67516168	2	1	206	1	0	0	0	0	0	0	0	1	14645	933	33	2		2	SLC35D1	1	67516168	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08	12370473	67516168	181734453	7	37582											
ZNF644	84146	broad.mit.edu	37	chr1	91406595	91406595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttaggcaagataaagttttCactagaaacagtaggagcac	16	10	9	6	0	1	2	1	0	0	2	1	3	1	3	0	2	2	4	0	2	7	7			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:91406595C>T	uc001dnw.2	-	3	458	c.316G>A	c.(316-318)GAA>AAA	p.E106K	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.E106K	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	106					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		ATAAAGTTTTCACTAGAAACA	0.408													10	45					0	0	0	0	T	91406595	T	T	91406595	3	4	206	1	0	0	0	0	1	0	0	0	18127	835	29	2	3683	2	ZNF644	1	91406595	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	23890427	91406595	157844026	8	37583											
LIX1L	128077	broad.mit.edu	37	chr1	145477381	145477381	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccggcgccgccggcagcccgGcagtgctgcgagaggccgtg	4	3	18	16	7	0	1	0	0	0	1	0	2	0	1	5	4	3	3	5	4	0	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:145477381G>A	uc001enr.2	+	1	297	c.223G>A	c.(223-225)GCA>ACA	p.A75T	NBPF10_uc001emp.3_Intron	NM_153713	NP_714924	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse) like	75										ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGGCAGCCCGGCAGTGCTGCG	0.562													3	4					0	0	0	0	A	145477381	A	A	145477381	3	1	206	1	0	0	0	0	1	0	0	0	8874	1203	42	4	225	4	LIX1L	1	145477381	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	54070786	145477381	103773240	9	37584											
ACP6	51205	broad.mit.edu	37	chr1	147142082	147142083	+	Frame_Shift_Ins	INS	-	C	C																															ctcctgcagctcggccagggINSccacccgccgctggtgcagg																								rs139439515	by1000genomes	TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:147142082_147142083insC	uc001epr.2	-	1	552_553	c.88_89insG	c.(88-90)GCCfs	p.A30fs	ACP6_uc009wjj.1_Frame_Shift_Ins_p.A30fs	NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	30					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					CTCGGCCAGGGCCACCCGCCGC	0.649													---	---	---								C	147142083	C	C	147142082	7	5	206	1	0	1	1	0	0	0	0	0	165	1203	42	0	1237	0	ACP6	1	147142082	Frame_Shift_Ins	INS	-	TCGA-CV-6951-01A-11D-1912-08	1664701	147142082	102108539	10	37585											
NUP210L	91181	broad.mit.edu	37	chr1	154062033	154062033	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacagctggactagggttcAggacacctggatgatttcca	10	10	11	10	0	1	1	1	1	0	0	2	4	2	4	2	4	2	2	2	4	2	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:154062033A>C	uc001fdw.2	-	16	2297	c.2225T>G	c.(2224-2226)CTG>CGG	p.L742R	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.L742R	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	742						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ACTAGGGTTCAGGACACCTGG	0.473													15	78					0	0	0	0	C	154062033	C	C	154062033	3	2	206	1	0	0	0	0	1	0	0	0	10815	188	7	5	3541	5	NUP210L	1	154062033	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08	6919951	154062033	95188588	11	37586											
SPTA1	6708	broad.mit.edu	37	chr1	158595954	158595954	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgttttgccagaagagtGaggaagtcaccaaggtctgc	11	9	12	9	0	2	3	1	1	1	2	2	4	2	4	3	2	2	1	3	2	3	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:158595954G>T	uc001fst.1	-	42	6091	c.5892C>A	c.(5890-5892)CTC>CTA	p.L1964L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1964	Spectrin 19.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCAGAAGAGTGAGGAAGTCAC	0.393													4	27					1.23904e-05	3.26788e-05	1	0	T	158595954	T	T	158595954	2	4	206	1	0	0	0	0	0	0	0	1	15182	1277	45	2		2	SPTA1	1	158595954	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08	4533921	158595954	90654667	12	37587											
ZNF648	127665	broad.mit.edu	37	chr1	182026706	182026706	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgagtatccatcatcacccGcaggtagtcggtccccaaga	10	7	9	15	3	2	1	2	0	0	1	5	2	4	1	5	2	0	3	5	2	3	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:182026706G>A	uc001goz.2	-	2	648	c.440C>T	c.(439-441)GCG>GTG	p.A147V		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATCATCACCCGCAGGTAGTCG	0.562													10	50					0	0	0	0	A	182026706	A	A	182026706	3	1	206	1	0	0	0	0	1	0	0	0	18130	1087	38	1	1270	1	ZNF648	1	182026706	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	23430752	182026706	67223915	13	37588											
HMCN1	83872	broad.mit.edu	37	chr1	186057074	186057074	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttttaggtatctgacaCaggccagtatgtatgtagag	10	15	10	6	0	2	2	0	1	2	1	2	2	2	2	1	2	0	4	1	2	5	7			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:186057074C>G	uc001grq.1	+	61	9603	c.9374C>G	c.(9373-9375)ACA>AGA	p.T3125R		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3125	Ig-like C2-type 29.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTATCTGACACAGGCCAGTAT	0.348													6	52					0	0	0	0	G	186057074	G	G	186057074	3	3	206	1	0	0	0	0	1	0	0	0	7259	478	17	4	9616	4	HMCN1	1	186057074	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	4030368	186057074	63193547	14	37589											
CFHR2	3080	broad.mit.edu	37	chr1	196928195	196928195	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggaaactggtatatcccagTtgtgaagaaaaatagaatca	17	9	10	5	0	1	3	1	1	0	2	2	4	2	4	1	2	1	2	1	2	8	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:196928195T>G	uc001gtq.1	+	5	875	c.798T>G	c.(796-798)AGT>AGG	p.S266R	CFHR2_uc001gtr.1_Missense_Mutation_p.S142R	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	266	Sushi 4.					extracellular region				skin(2)|ovary(1)	3						TATATCCCAGTTGTGAAGAAA	0.303													12	33					0	0	0	0	G	196928195	G	G	196928195	3	3	206	1	0	0	0	0	1	0	0	0	3300	1722	60	5	816	5	CFHR2	1	196928195	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08	10871121	196928195	52322426	15	37590											
NAV1	89796	broad.mit.edu	37	chr1	201759817	201759817	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatttctcttccttttacagCaaatccggaagcttcgtagg	9	15	7	10	2	1	0	0	0	1	0	5	1	3	1	2	2	3	3	2	2	5	7			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:201759817C>A	uc001gwu.2	+	13	3591	c.3244C>A	c.(3244-3246)CAA>AAA	p.Q1082K	NAV1_uc001gwv.1_Missense_Mutation_p.Q582K|NAV1_uc001gww.1_Missense_Mutation_p.Q683K|NAV1_uc001gwx.2_Missense_Mutation_p.Q691K|NAV1_uc001gwy.1_Missense_Mutation_p.Q455K	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1082	Potential.				cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CCTTTTACAGCAAATCCGGAA	0.448													18	89					1.67942e-08	4.64673e-08	1	0	A	201759817	A	A	201759817	3	1	206	1	0	0	0	0	1	0	0	0	10236	724	25	4	3351	4	NAV1	1	201759817	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	4831622	201759817	47490804	16	37591											
PPFIA4	8497	broad.mit.edu	37	chr1	203036878	203036878	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggctgaattatgaccggaagGagctggagaagaggcgagag	13	5	18	5	2	0	5	0	2	0	3	0	9	0	7	1	5	1	2	1	5	4	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:203036878G>A	uc001gyz.2	+	13	2181	c.1588G>A	c.(1588-1590)GAG>AAG	p.E530K	PPFIA4_uc009xaj.2_Missense_Mutation_p.E1161K|PPFIA4_uc010pqf.1_Missense_Mutation_p.E743K|PPFIA4_uc001gza.2_Missense_Mutation_p.E521K|PPFIA4_uc001gzb.1_Missense_Mutation_p.E216K|PPFIA4_uc001gzc.1_Missense_Mutation_p.E72K	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	530	Potential.				cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						TGACCGGAAGGAGCTGGAGAA	0.582													26	54					0	0	0	0	A	203036878	A	A	203036878	3	1	206	1	0	0	0	0	1	0	0	0	12367	1175	41	2	1638	2	PPFIA4	1	203036878	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	1277061	203036878	46213743	17	37592											
ZP4	57829	broad.mit.edu	37	chr1	238048742	238048742	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcagggggtcagtgctgggtGttgcccaacactgttgtagg	6	11	16	8	0	2	0	2	0	0	0	2	0	2	0	1	4	3	4	1	4	2	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:238048742G>A	uc001hym.2	-	8	1109	c.1109C>T	c.(1108-1110)ACA>ATA	p.T370I	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	370	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AGTGCTGGGTGTTGCCCAACA	0.537													17	56					0	0	0	0	A	238048742	A	A	238048742	3	1	206	1	0	0	0	0	1	0	0	0	18285	1377	48	4	533	4	ZP4	1	238048742	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	35011864	238048742	11201879	18	37593											
ZNF669	79862	broad.mit.edu	37	chr1	247264162	247264162	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccttacattcgtagggtttCtctccagtgtgagttcgttc	5	17	9	10	2	1	1	0	1	1	0	7	1	3	1	2	1	1	4	2	1	2	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:247264162C>G	uc001ice.2	-	4	1082	c.909G>C	c.(907-909)GAG>GAC	p.E303D	ZNF669_uc001icf.2_Missense_Mutation_p.E217D	NM_024804	NP_079080	Q96BR6	ZN669_HUMAN	zinc finger protein 669 isoform 1	303					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;4.09e-05)|all_epithelial(71;6.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0283)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00427)			CGTAGGGTTTCTCTCCAGTGT	0.383													7	49					0	0	0	0	G	247264162	G	G	247264162	3	3	206	1	0	0	0	0	1	0	0	0	18143	912	32	2	489	2	ZNF669	1	247264162	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	9215420	247264162	1986459	19	37594											
OR2T3	343173	broad.mit.edu	37	chr1	248637569	248637569	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagatgtcaccagggctctGaggagcatgatgcagtcaag	13	7	13	8	0	3	3	2	2	1	1	3	4	3	4	1	2	2	3	1	2	2	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:248637569G>A	uc001iel.1	+	1	918	c.918G>A	c.(916-918)CTG>CTA	p.L306L		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	306	Cytoplasmic (Potential).			L -> M (in Ref. 3; BAC05839).	sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCAGGGCTCTGAGGAGCATGA	0.478													44	349					0	0	0	0	A	248637569	A	A	248637569	2	1	206	1	0	0	0	0	0	0	0	1	11077	1277	45	2		2	OR2T3	1	248637569	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08	1373407	248637569	613052	20	37595											
ZNF692	55657	broad.mit.edu	37	chr1	249151487	249151487	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaacttctccgagtagtatGtggaagggaggctggcttgg	8	10	15	8	1	1	0	0	0	1	0	2	3	1	2	2	5	1	4	2	5	4	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr1:249151487G>C	uc001ifc.1	-	4	588	c.421C>G	c.(421-423)CAT>GAT	p.H141D	ZNF692_uc001iez.1_5'Flank|ZNF692_uc001ifa.1_5'UTR|ZNF692_uc001ifb.1_5'UTR|ZNF692_uc001ifd.1_Missense_Mutation_p.H141D|ZNF692_uc001ife.1_RNA|ZNF692_uc001iff.1_Missense_Mutation_p.H141D|ZNF692_uc010pzr.1_Missense_Mutation_p.H146D	NM_017865	NP_060335	Q9BU19	ZN692_HUMAN	zinc finger protein 692 isoform 2	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CGAGTAGTATGTGGAAGGGAG	0.567													42	53					0	0	0	0	C	249151487	C	C	249151487	3	2	206	1	0	0	0	0	1	0	0	0	18164	1377	48	4	1174	4	ZNF692	1	249151487	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	513918	249151487	99134	21	37596											
C2orf16	84226	broad.mit.edu	37	chr2	27804296	27804296	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcactgcagtccccccgaGaggagctgtcacagtctctc	9	8	9	15	1	3	1	2	0	1	1	6	3	4	2	3	1	2	2	3	1	1	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:27804296G>A	uc002rkz.3	+	1	4908	c.4857G>A	c.(4855-4857)GAG>GAA	p.E1619E	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1619	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					GTCCCCCCGAGAGGAGCTGTC	0.562													32	71					0	0	0	0	A	27804296	A	A	27804296	2	1	206	1	0	0	0	0	0	0	0	1	2167	933	33	2		2	C2orf16	2	27804296	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08		27804296	215395077	22	37597											
C2orf16	84226	broad.mit.edu	37	chr2	27804510	27804510	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagccattgcagtccctctGagagaagacatcgcagtccc	11	7	10	13	1	1	3	0	1	1	2	4	5	3	3	3	0	2	2	3	0	2	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:27804510G>T	uc002rkz.3	+	1	5122	c.5071G>T	c.(5071-5073)GAG>TAG	p.E1691*	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1691	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.|8.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CAGTCCCTCTGAGAGAAGACA	0.577													41	140					2.05212e-20	5.93273e-20	1	0	T	27804510	T	T	27804510	4	4	206	1	0	0	0	0	0	1	0	0	2167	1291	45	2	5073	2	C2orf16	2	27804510	Nonsense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	214	27804510	215394863	23	37598											
WDR92	116143	broad.mit.edu	37	chr2	68365916	68365916	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccgtaatgccatatttctGagatcaaatagtttgatatc	13	14	6	8	1	2	2	1	2	1	1	3	3	2	2	2	0	1	2	2	0	5	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:68365916G>C	uc002see.1	-	5	672	c.591C>G	c.(589-591)CTC>CTG	p.L197L	WDR92_uc002sed.1_RNA|WDR92_uc002sef.1_Silent_p.L197L|WDR92_uc002seg.1_Silent_p.L96L	NM_138458	NP_612467	Q96MX6	WDR92_HUMAN	monad	197	WD 3.				apoptosis|histone lysine methylation		methylated histone residue binding				0						CCATATTTCTGAGATCAAATA	0.383													32	114					0	0	0	0	C	68365916	C	C	68365916	2	2	206	1	0	0	0	0	0	0	0	1	17407	1277	45	2		2	WDR92	2	68365916	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08	40561406	68365916	174833457	24	37599											
PLEK	5341	broad.mit.edu	37	chr2	68615548	68615548	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggttcttctgtgaagagaaTtccagtgatgatgatgtgat	10	14	13	4	0	2	6	0	5	2	1	3	7	3	6	1	1	0	1	1	1	2	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:68615548T>G	uc002sen.3	+	6	849	c.687T>G	c.(685-687)AAT>AAG	p.N229K	PLEK_uc010fde.2_Missense_Mutation_p.N229K	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	229					actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		GTGAAGAGAATTCCAGTGATG	0.453													42	42					0	0	0	0	G	68615548	G	G	68615548	3	3	206	1	0	0	0	0	1	0	0	0	12108	1490	52	5	709	5	PLEK	2	68615548	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08	249632	68615548	174583825	25	37600											
DPP10	57628	broad.mit.edu	37	chr2	116572538	116572538	+	Frame_Shift_Del	DEL	G	-	-																															gaagattaggttcagtagaaGtaaaggaccaaataacagct																										TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:116572538delG	uc002tla.1	+	20	2327	c.1870delG	c.(1870-1872)GTAfs	p.V624fs	DPP10_uc002tlb.1_Frame_Shift_Del_p.V574fs|DPP10_uc002tlc.1_Frame_Shift_Del_p.V620fs|DPP10_uc002tle.2_Frame_Shift_Del_p.V628fs|DPP10_uc002tlf.1_Frame_Shift_Del_p.V617fs	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	624	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TTCAGTAGAAGTAAAGGACCA	0.358													---	---	---								-	116572538	-	-	116572538	7	5	206	1	0	1	0	1	0	0	0	0	4749	1029	36	0	2119	0	DPP10	2	116572538	Frame_Shift_Del	DEL	G	TCGA-CV-6951-01A-11D-1912-08	47956990	116572538	126626835	26	37601											
SAP130	79595	broad.mit.edu	37	chr2	128712891	128712891	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaccggagtggccatagaCacgtggatttcagacttggg	9	9	15	8	2	1	3	1	1	0	2	1	5	1	5	2	4	0	0	2	4	1	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:128712891C>A	uc002tpp.2	-	15	2196	c.2064G>T	c.(2062-2064)GTG>GTT	p.V688V	SAP130_uc002tpn.2_Silent_p.V448V|SAP130_uc002tpo.2_Silent_p.V468V|SAP130_uc010fmd.2_Silent_p.V723V|SAP130_uc002tpq.1_Silent_p.V696V	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	688					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TGGCCATAGACACGTGGATTT	0.463													16	52					3.45872e-05	9.01666e-05	1	0	A	128712891	A	A	128712891	2	1	206	1	0	0	0	0	0	0	0	1	13896	465	17	4		4	SAP130	2	128712891	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	12140353	128712891	114486482	27	37602											
SPOPL	339745	broad.mit.edu	37	chr2	139316665	139316665	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgaaggtgcctgagtgtcGtctagcagaagatttaggta	10	13	13	5	1	1	4	0	2	1	2	2	4	1	4	1	2	2	2	1	2	5	5			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:139316665G>T	uc002tvh.2	+	6	954	c.554G>T	c.(553-555)CGT>CTT	p.R185L		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	185						nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		CCTGAGTGTCGTCTAGCAGAA	0.368													29	55					1.2476e-16	3.58387e-16	1	0	T	139316665	T	T	139316665	3	4	206	1	0	0	0	0	1	0	0	0	15151	1145	40	3	572	3	SPOPL	2	139316665	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	10603774	139316665	103882708	28	37603											
FIGN	55137	broad.mit.edu	37	chr2	164466892	164466892	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	accagcaatgtcattccagtCcactggaggtccttgggtga	9	10	11	11	0	1	1	1	1	0	0	4	2	4	2	4	3	1	1	4	3	1	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:164466892C>G	uc002uck.1	-	3	1761	c.1450G>C	c.(1450-1452)GAC>CAC	p.D484H		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	484						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						TCATTCCAGTCCACTGGAGGT	0.512													11	89					0	0	0	0	G	164466892	G	G	164466892	3	3	206	1	0	0	0	0	1	0	0	0	5923	855	30	2	833	2	FIGN	2	164466892	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	25150227	164466892	78732481	29	37604											
NFE2L2	4780	broad.mit.edu	37	chr2	178098960	178098960	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcgacttactccaagatCtatatcttgcctccaaagta	11	14	4	12	1	3	1	0	0	3	1	6	2	5	1	3	0	2	1	3	0	6	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:178098960C>G	uc002ulh.3	-	2	640	c.85G>C	c.(85-87)GAT>CAT	p.D29H	NFE2L2_uc002ulg.3_Missense_Mutation_p.D13H|NFE2L2_uc010zfa.1_Missense_Mutation_p.D13H|NFE2L2_uc002uli.3_Missense_Mutation_p.D13H|NFE2L2_uc010fra.2_Missense_Mutation_p.D13H|NFE2L2_uc010frb.2_Missense_Mutation_p.D13H	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	29					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ACTCCAAGATCTATATCTTGC	0.363			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			9	36					0	0	0	0	G	178098960	G	G	178098960	3	3	206	1	0	0	0	0	1	0	0	0	10422	913	32	2	1748	2	NFE2L2	2	178098960	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	13632068	178098960	65100413	30	37605											
GULP1	51454	broad.mit.edu	37	chr2	189434754	189434754	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caataatgattttctttttaGatccaagacttagaaacaga	16	14	5	6	0	1	5	0	1	1	4	2	5	2	5	1	0	1	0	1	0	6	7			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:189434754G>T	uc010fru.2	+	9	978	c.517_splice	c.e9-1	p.I173_splice	GULP1_uc002uqd.2_Splice_Site_p.I173_splice|GULP1_uc010zfw.1_Splice_Site_p.I70_splice|GULP1_uc002uqf.2_Splice_Site_p.I173_splice|GULP1_uc002uqg.2_Splice_Site_p.I173_splice|GULP1_uc002uqh.1_5'Flank	NM_016315	NP_057399	Q9UBP9	GULP1_HUMAN	GULP, engulfment adaptor PTB domain containing						apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)			TTTCTTTTTAGATCCAAGACT	0.279													6	22					3.59834e-05	9.32672e-05	1	0	T	189434754	T	T	189434754	5	4	206	1	0	0	0	0	0	0	1	0	6940	956	33	2	542	2	GULP1	2	189434754	Splice_Site	SNP	G	TCGA-CV-6951-01A-11D-1912-08	11335794	189434754	53764619	31	37606											
COL3A1	1281	broad.mit.edu	37	chr2	189867029	189867029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatttttctcttcagggtgaGagaggtgaaactggccctcc	8	13	11	9	0	2	3	1	2	1	1	4	4	3	3	2	3	1	0	2	3	2	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:189867029G>C	uc002uqj.1	+	35	2514	c.2397G>C	c.(2395-2397)GAG>GAC	p.E799D		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	799	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTCAGGGTGAGAGAGGTGAAA	0.438													9	31					0	0	0	0	C	189867029	C	C	189867029	3	2	206	1	0	0	0	0	1	0	0	0	3703	933	33	2	2535	2	COL3A1	2	189867029	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	432275	189867029	53332344	32	37607											
ATIC	471	broad.mit.edu	37	chr2	216191665	216191665	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acccacatcagacccctgccCagctgtacacactgcagccc	10	5	6	20	0	1	1	1	0	0	1	1	1	1	1	5	0	5	3	5	0	1	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr2:216191665C>A	uc002vex.3	+	7	826	c.652C>A	c.(652-654)CAG>AAG	p.Q218K	ATIC_uc010zjo.1_Missense_Mutation_p.Q159K|ATIC_uc002vey.3_Missense_Mutation_p.Q217K	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	218					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	GACCCCTGCCCAGCTGTACAC	0.483			T	ALK	ALCL								26	79					7.92952e-12	2.24919e-11	1	0	A	216191665	A	A	216191665	3	1	206	1	0	0	0	0	1	0	0	0	1107	595	21	4	678	4	ATIC	2	216191665	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	26324636	216191665	27007708	33	37608											
PTH1R	5745	broad.mit.edu	37	chr3	46937299	46937299	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaggaaagataaggcatctGggaagctctaccctgagtct	12	8	11	10	0	3	2	0	1	3	1	3	4	3	4	2	3	2	2	2	3	4	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr3:46937299G>T	uc003cqm.2	+	5	456	c.253G>T	c.(253-255)GGG>TGG	p.G85W	PTH1R_uc003cqn.2_Missense_Mutation_p.G85W	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	85	Extracellular (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						TAAGGCATCTGGGAAGCTCTA	0.552									Ollier_disease_/_Maffuci_syndrome		OREG0015543	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	26					2.17888e-05	5.71322e-05	1	0	T	46937299	T	T	46937299	3	4	206	1	0	0	0	0	1	0	0	0	12821	1348	47	4	263	4	PTH1R	3	46937299	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08		46937299	151085131	34	37609											
NICN1	84276	broad.mit.edu	37	chr3	49466588	49466588	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatcgatgaccagcacgcCaggccggccttgggaggtcc	8	5	14	14	3	0	1	0	1	0	0	2	4	1	2	5	4	1	1	5	4	0	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr3:49466588C>T	uc003cwz.1	-	1	170	c.85G>A	c.(85-87)GGC>AGC	p.G29S	NICN1_uc003cxa.2_RNA|NICN1_uc011bcr.1_Missense_Mutation_p.G29S	NM_032316	NP_115692	Q9BSH3	NICN1_HUMAN	nicolin 1	29						microtubule|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;4.52e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACCAGCACGCCAGGCCGGCCT	0.682													10	18					0	0	0	0	T	49466588	T	T	49466588	3	4	206	1	0	0	0	0	1	0	0	0	10467	594	21	4	580	4	NICN1	3	49466588	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	2529289	49466588	148555842	35	37610											
C3orf63	23272	broad.mit.edu	37	chr3	56675420	56675420	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtgcccacttcgctggtaGaaatagcaacagaatactta	14	9	8	10	1	0	2	0	0	0	2	1	2	0	2	1	1	4	3	1	1	7	5			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr3:56675420G>C	uc003did.3	-	15	2677	c.2576C>G	c.(2575-2577)TCT>TGT	p.S859C	C3orf63_uc003dic.3_Missense_Mutation_p.S463C|C3orf63_uc003die.3_Missense_Mutation_p.S859C	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	859										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		TTCGCTGGTAGAAATAGCAAC	0.403													5	18					0	0	0	0	C	56675420	C	C	56675420	3	2	206	1	0	0	0	0	1	0	0	0	2249	942	33	2	2536	2	C3orf63	3	56675420	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	7208832	56675420	141347010	36	37611											
PARP15	165631	broad.mit.edu	37	chr3	122340298	122340298	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctttttttcagctgcacaGcctcacagagattttataat	10	16	5	10	0	2	1	2	0	0	1	3	2	3	1	2	0	3	2	2	0	2	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr3:122340298G>T	uc003efm.2	+	8	1137	c.1071G>T	c.(1069-1071)CAG>CAT	p.Q357H	PARP15_uc003efn.2_Missense_Mutation_p.Q231H|PARP15_uc003efo.1_Missense_Mutation_p.Q104H|PARP15_uc003efp.1_Missense_Mutation_p.Q123H|PARP15_uc011bjt.1_Missense_Mutation_p.Q123H	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	335	Macro 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		CAGCTGCACAGCCTCACAGAG	0.393													38	22					1.8453e-21	5.40408e-21	1	0	T	122340298	T	T	122340298	3	4	206	1	0	0	0	0	1	0	0	0	11513	962	34	4	1170	4	PARP15	3	122340298	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	65664878	122340298	75682132	37	37612											
TXNDC6	347736	broad.mit.edu	37	chr3	138023770	138023770	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgggggcccatgacggttcGccaggtagtgaccacgtcct	7	7	14	13	4	0	2	0	2	0	0	2	2	1	2	4	4	0	2	4	4	1	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr3:138023770G>A	uc003esg.2	-	9	764	c.736C>T	c.(736-738)CGA>TGA	p.R246*	TXNDC6_uc003esd.1_Intron|TXNDC6_uc010huf.1_Nonsense_Mutation_p.R161*|TXNDC6_uc003ese.1_Nonsense_Mutation_p.R185*	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	246	NDK.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						ATGACGGTTCGCCAGGTAGTG	0.572													30	170					0	0	0	0	A	138023770	A	A	138023770	4	1	206	1	0	0	0	0	0	1	0	0	16868	1095	38	1	250	1	TXNDC6	3	138023770	Nonsense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	15683472	138023770	59998660	38	37613											
OTOL1	131149	broad.mit.edu	37	chr3	161221279	161221279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactgggaagaagggctctcGgggctttaaaggctccaagg	10	7	15	9	1	1	1	0	0	1	1	3	2	2	2	1	6	0	3	1	6	5	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr3:161221279G>A	uc011bpb.1	+	4	983	c.983G>A	c.(982-984)CGG>CAG	p.R328Q		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	328	Collagen-like 3.					collagen					0						AAGGGCTCTCGGGGCTTTAAA	0.572													4	27					0	0	0	0	A	161221279	A	A	161221279	3	1	206	1	0	0	0	0	1	0	0	0	11358	1116	39	1	997	1	OTOL1	3	161221279	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	23197509	161221279	36801151	39	37614											
PPEF2	5470	broad.mit.edu	37	chr4	76811247	76811247	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcatctcggagtcctgggCgaatctgtcctcagtgaata	8	12	10	11	2	4	1	2	1	2	0	7	3	6	2	2	2	0	0	2	2	3	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr4:76811247C>T	uc003hix.2	-	5	637	c.280G>A	c.(280-282)GCC>ACC	p.A94T	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.A94T	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	94					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GAGTCCTGGGCGAATCTGTCC	0.522													35	38					0	0	0	0	T	76811247	T	T	76811247	3	4	206	1	0	0	0	0	1	0	0	0	12363	768	27	1	2033	1	PPEF2	4	76811247	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08		76811247	114343029	40	37615											
PDHA2	5161	broad.mit.edu	37	chr4	96761704	96761704	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtccgatccattctcgcaGagctgacgggaagaagagga	11	7	13	10	3	1	4	0	1	1	3	4	7	3	6	2	2	1	2	2	2	2	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr4:96761704G>C	uc003htr.3	+	1	466	c.403G>C	c.(403-405)GAG>CAG	p.E135Q		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	135					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CATTCTCGCAGAGCTGACGGG	0.512													41	37					0	0	0	0	C	96761704	C	C	96761704	3	2	206	1	0	0	0	0	1	0	0	0	11719	943	33	2	405	2	PDHA2	4	96761704	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	19950457	96761704	94392572	41	37616											
CCRN4L	25819	broad.mit.edu	37	chr4	139965958	139965958	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttccagccactcctcagtaGactaggctatcaaggcacgt	10	9	8	14	1	2	1	2	0	0	1	4	1	4	1	3	2	1	3	3	2	4	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr4:139965958G>C	uc003ihl.2	+	3	819	c.626G>C	c.(625-627)AGA>ACA	p.R209T		NM_012118	NP_036250	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like	209					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_hematologic(180;0.162)					CTCCTCAGTAGACTAGGCTAT	0.458													16	77					0	0	0	0	C	139965958	C	C	139965958	3	2	206	1	0	0	0	0	1	0	0	0	2966	942	33	2	636	2	CCRN4L	4	139965958	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	43204254	139965958	51188318	42	37617											
TKTL2	84076	broad.mit.edu	37	chr4	164394488	164394488	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtataagccattccacaTgcagtacctaatccctgacc	12	9	5	15	0	0	1	0	1	0	0	2	1	2	1	6	0	3	3	6	0	4	5			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr4:164394488T>A	uc003iqp.3	-	1	560	c.399A>T	c.(397-399)GCA>GCT	p.A133A		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	133						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCATTCCACATGCAGTACCTA	0.547													20	65					0	0	0	0	A	164394488	A	A	164394488	2	1	206	1	0	0	0	0	0	0	0	1	16002	1451	51	5		5	TKTL2	4	164394488	Silent	SNP	T	TCGA-CV-6951-01A-11D-1912-08	24428530	164394488	26759788	43	37618											
TTC33	23548	broad.mit.edu	37	chr5	40716573	40716573	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggttcattggatagatgtGaagggctacttgaaaacttc	12	12	12	5	0	1	3	1	2	0	1	2	4	1	4	0	3	2	2	0	3	5	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr5:40716573G>A	uc003jma.2	-	5	611	c.463C>T	c.(463-465)CAC>TAC	p.H155Y	TTC33_uc011cpm.1_Missense_Mutation_p.H47Y|TTC33_uc010ivg.2_3'UTR	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	155	TPR 3.						binding			ovary(1)	1						GGATAGATGTGAAGGGCTACT	0.373													20	73					0	0	0	0	A	40716573	A	A	40716573	3	1	206	1	0	0	0	0	1	0	0	0	16770	1290	45	2	329	2	TTC33	5	40716573	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08		40716573	140198687	44	37619											
DHFR	1719	broad.mit.edu	37	chr5	79929781	79929781	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgatccttgtcacaaataGtttaagatggcctgggtgat	11	13	10	7	0	1	3	1	2	0	1	2	3	2	3	2	2	0	1	2	2	3	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr5:79929781G>T	uc003kgy.1	-	5	892	c.400C>A	c.(400-402)CTA>ATA	p.L134I	DHFR_uc011ctl.1_Intron|DHFR_uc011ctm.1_Missense_Mutation_p.L82I|DHFR_uc010jap.1_RNA|DHFR_uc003kgx.1_Missense_Mutation_p.L283I	NM_000791	NP_000782	P00374	DYR_HUMAN	dihydrofolate reductase	134	DHFR.				folic acid metabolic process|glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to methotrexate|tetrahydrofolate metabolic process	cytosol	dihydrofolate reductase activity|drug binding|folate reductase activity|NADP binding				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.69e-46)|Epithelial(54;7.49e-41)|all cancers(79;1.54e-35)	Dapsone(DB00250)|Dimethyl sulfoxide(DB01093)|Lamotrigine(DB00555)|Methotrexate(DB00563)|NADH(DB00157)|Pemetrexed(DB00642)|Proguanil(DB01131)|Pyrimethamine(DB00205)|Trimethoprim(DB00440)|Trimetrexate(DB01157)	GTCACAAATAGTTTAAGATGG	0.328													13	32					1.99824e-07	5.46185e-07	1	0	T	79929781	T	T	79929781	3	4	206	1	0	0	0	0	1	0	0	0	4503	1020	36	4	171	4	DHFR	5	79929781	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	39213208	79929781	100985479	45	37620											
ACOT12	134526	broad.mit.edu	37	chr5	80667608	80667608	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctctagtaacttttgctttGatggttataacttgtccaac	9	17	7	8	0	1	1	0	1	1	0	2	1	2	1	1	1	4	4	1	1	5	8			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr5:80667608G>C	uc003khl.3	-	3	274	c.219C>G	c.(217-219)ATC>ATG	p.I73M	RNU5E_uc011cto.1_Intron|ACOT12_uc003khm.2_Missense_Mutation_p.I73M	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	73	Acyl coenzyme A hydrolase 1.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		CTTTTGCTTTGATGGTTATAA	0.363													18	44					0	0	0	0	C	80667608	C	C	80667608	3	2	206	1	0	0	0	0	1	0	0	0	150	1280	45	2	1500	2	ACOT12	5	80667608	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	737827	80667608	100247652	46	37621											
MGAT4B	11282	broad.mit.edu	37	chr5	179226007	179226007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaggcccagaagaagtcctCgcgcaggtaggctttctcca	10	7	12	12	2	1	2	0	0	1	2	4	3	2	2	3	3	0	3	3	3	4	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr5:179226007C>T	uc003mks.2	-	11	1633	c.1264G>A	c.(1264-1266)GAG>AAG	p.E422K	MGAT4B_uc003mkp.2_Missense_Mutation_p.E276K|MGAT4B_uc003mkq.2_Missense_Mutation_p.R197Q|MGAT4B_uc003mkr.2_Missense_Mutation_p.E437K|MIR1229_hsa-mir-1229|MI0006319_5'Flank	NM_014275	NP_055090	Q9UQ53	MGT4B_HUMAN	alpha-1,3-mannosyl-glycoprotein	422	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding				0	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGAAGTCCTCGCGCAGGTAG	0.607													54	76					0	0	0	0	T	179226007	T	T	179226007	3	4	206	1	0	0	0	0	1	0	0	0	9599	893	31	1	402	1	MGAT4B	5	179226007	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	98558399	179226007	1689253	47	37622											
FAM136B	387071	broad.mit.edu	37	chr6	3045941	3045941	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtgaagcagcagctggaCggttgtgtgaccaagtgtgt	9	9	16	7	1	0	2	0	2	0	0	0	3	0	3	1	3	3	4	1	3	2	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr6:3045941C>T	uc011dhr.1	+	1	324	c.324C>T	c.(322-324)GAC>GAT	p.D108D		NM_001012983	NP_001013001			hypothetical protein LOC387071												0	Ovarian(93;0.0386)	all_hematologic(90;0.108)				AGCAGCTGGACGGTTGTGTGA	0.483													5	86					0	0	0	0	T	3045941	T	T	3045941	2	4	206	1	0	0	0	0	0	0	0	1	5479	535	19	1		1	FAM136B	6	3045941	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08		3045941	168069126	48	37623											
HIST1H2AE	3012	broad.mit.edu	37	chr6	26217479	26217479	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tagccatccgcaacgacgagGagctaaataagcttctaggt	13	8	10	10	3	1	0	0	0	1	0	2	3	2	1	2	2	4	3	2	2	6	5			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr6:26217479G>A	uc003nha.1	+	1	332	c.277G>A	c.(277-279)GAG>AAG	p.E93K	HIST1H2BG_uc003ngz.2_5'Flank	NM_021052	NP_066390	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	93					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2		all_hematologic(11;0.196)				CAACGACGAGGAGCTAAATAA	0.592													19	76					0	0	0	0	A	26217479	A	A	26217479	3	1	206	1	0	0	0	0	1	0	0	0	7171	1175	41	2	279	2	HIST1H2AE	6	26217479	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	23171538	26217479	144897588	49	37624											
PGBD1	84547	broad.mit.edu	37	chr6	28268867	28268867	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattctggacttttgaatctCaagagcgaaaagttgaaccc	13	11	9	8	1	2	3	1	2	2	1	3	6	2	4	1	1	2	1	1	1	5	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr6:28268867C>G	uc003nky.2	+	7	1606	c.1236C>G	c.(1234-1236)CTC>CTG	p.L412L	PGBD1_uc003nkz.2_Silent_p.L412L	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	412					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						TTTTGAATCTCAAGAGCGAAA	0.348													15	67					0	0	0	0	G	28268867	G	G	28268867	2	3	206	1	0	0	0	0	0	0	0	1	11835	813	29	2		2	PGBD1	6	28268867	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	2051388	28268867	142846200	50	37625											
RNF8	9025	broad.mit.edu	37	chr6	37344797	37344797	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caatgtattatttgttcagaAtacttcattgaggtaattat	13	18	6	4	0	2	2	2	1	0	1	2	2	2	2	0	1	1	3	0	1	7	9			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr6:37344797A>G	uc003onq.3	+	6	1417	c.1224A>G	c.(1222-1224)GAA>GAG	p.E408E	RNF8_uc003onr.3_Silent_p.E408E|RNF8_uc011dtx.1_Silent_p.E340E	NM_003958	NP_003949	O76064	RNF8_HUMAN	ring finger protein 8 isoform 1	408	RING-type.				cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						TTTGTTCAGAATACTTCATTG	0.284													7	9					0	0	0	0	G	37344797	G	G	37344797	2	3	206	1	0	0	0	0	0	0	0	1	13565	98	4	5		5	RNF8	6	37344797	Silent	SNP	A	TCGA-CV-6951-01A-11D-1912-08	9075930	37344797	133770270	51	37626											
EPHA7	2045	broad.mit.edu	37	chr6	94120657	94120657	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatattcctgccagtgtcatAgtctgtttcataatagtaca	11	16	6	8	0	3	0	2	0	1	0	4	0	4	0	2	0	2	2	2	0	6	8			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr6:94120657A>T	uc003poe.2	-	3	635	c.394T>A	c.(394-396)TAT>AAT	p.Y132N	EPHA7_uc003pof.2_Missense_Mutation_p.Y132N|EPHA7_uc011eac.1_Missense_Mutation_p.Y132N|EPHA7_uc003pog.3_Missense_Mutation_p.Y132N	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	132	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CCAGTGTCATAGTCTGTTTCA	0.368													33	46					0	0	0	0	T	94120657	T	T	94120657	3	4	206	1	0	0	0	0	1	0	0	0	5196	420	15	5	2662	5	EPHA7	6	94120657	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08	56775860	94120657	76994410	52	37627											
C6orf170	221322	broad.mit.edu	37	chr6	121563420	121563420	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacctgttctttgaagaagtAgtaatcctttgggggtggca	9	13	12	7	0	1	2	0	1	1	1	2	2	2	2	2	3	0	4	2	3	4	5			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr6:121563420A>T	uc003pyo.1	-	18	2152	c.2084T>A	c.(2083-2085)CTA>CAA	p.L695Q	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_Missense_Mutation_p.L214Q	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	695					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		TTGAAGAAGTAGTAATCCTTT	0.343													16	49					0	0	0	0	T	121563420	T	T	121563420	3	4	206	1	0	0	0	0	1	0	0	0	2354	420	15	5	1749	5	C6orf170	6	121563420	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08	27442763	121563420	49551647	53	37628											
LAMA2	3908	broad.mit.edu	37	chr6	129475657	129475657	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttccttaatgcagcatgcaaTtgtcatggaaaagctgaaga	14	11	9	7	0	1	2	1	1	0	1	2	3	2	3	1	1	4	4	1	1	5	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr6:129475657T>A	uc003qbn.2	+	8	1140	c.1035T>A	c.(1033-1035)AAT>AAA	p.N345K	LAMA2_uc003qbo.2_Missense_Mutation_p.N345K	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	345	Laminin EGF-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CAGCATGCAATTGTCATGGAA	0.289													14	32					0	0	0	0	A	129475657	A	A	129475657	3	1	206	1	0	0	0	0	1	0	0	0	8646	1490	52	5	1065	5	LAMA2	6	129475657	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08	7912237	129475657	41639410	54	37629											
HBS1L	10767	broad.mit.edu	37	chr6	135371740	135371740	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgttgacggcgaaatacaaTaatcatcctctacagactgg	13	10	8	10	2	2	2	1	1	1	1	3	3	3	2	1	2	2	1	1	2	5	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr6:135371740T>C	uc003qez.2	-	2	296	c.89A>G	c.(88-90)TAT>TGT	p.Y30C	HBS1L_uc011ecy.1_5'UTR|HBS1L_uc011ecz.1_5'UTR|HBS1L_uc011eda.1_Missense_Mutation_p.Y30C|HBS1L_uc003qfa.2_Missense_Mutation_p.Y30C	NM_006620	NP_006611	Q9Y450	HBS1L_HUMAN	Hsp70 subfamily B suppressor 1-like protein	30					signal transduction		GTP binding|GTPase activity|translation elongation factor activity			skin(2)	2	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		CGAAATACAATAATCATCCTC	0.299													10	8					0	0	0	0	C	135371740	C	C	135371740	3	2	206	1	0	0	0	0	1	0	0	0	7026	1406	49	5	3506	5	HBS1L	6	135371740	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08	5896083	135371740	35743327	55	37630											
SLC22A2	6582	broad.mit.edu	37	chr6	160666488	160666488	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccagttgtacatcaatatCatagtatgtttccttatctg	11	17	5	8	0	3	0	2	0	1	0	4	0	4	0	2	0	2	4	2	0	7	8			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr6:160666488C>T	uc003qtf.2	-	6	1217	c.1047G>A	c.(1045-1047)ATG>ATA	p.M349I	SLC22A2_uc003qte.1_Missense_Mutation_p.M349I	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	349	Helical; (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		ACATCAATATCATAGTATGTT	0.373													7	25					0	0	0	0	T	160666488	T	T	160666488	3	4	206	1	0	0	0	0	1	0	0	0	14515	826	29	2	644	2	SLC22A2	6	160666488	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	25294748	160666488	10448579	56	37631											
MEOX2	4223	broad.mit.edu	37	chr7	15725704	15725704	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagagtcgggctggaggcaGaggctgtgccgagccgcact	7	5	17	12	3	0	2	0	0	0	2	1	4	0	3	3	4	2	4	3	4	0	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr7:15725704G>T	uc003stc.2	-	1	605	c.324C>A	c.(322-324)CTC>CTA	p.L108L	MEOX2_uc011jxw.1_Silent_p.L108L	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	108					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		GCTGGAGGCAGAGGCTGTGCC	0.567													10	3					4.68919e-08	1.28953e-07	1	0	T	15725704	T	T	15725704	2	4	206	1	0	0	0	0	0	0	0	1	9527	929	33	2		2	MEOX2	7	15725704	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08		15725704	143412959	57	37632											
FKBP14	55033	broad.mit.edu	37	chr7	30066006	30066006	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatcccctcctttggtcttgCgatggcagatgaatggcttc	7	13	10	11	1	1	2	0	1	1	1	4	3	3	2	3	3	1	2	3	3	2	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr7:30066006C>T	uc003tal.1	-	1	263	c.119G>A	c.(118-120)CGC>CAC	p.R40H	PLEKHA8_uc003tao.2_5'Flank|PLEKHA8_uc003tap.1_5'Flank|FKBP14_uc010kvq.1_RNA|PLEKHA8_uc003tam.1_5'Flank|PLEKHA8_uc003tan.2_5'Flank	NM_017946	NP_060416	Q9NWM8	FKB14_HUMAN	FK506 binding protein 14 precursor	40					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						TTTGGTCTTGCGATGGCAGAT	0.468													6	206					0	0	0	0	T	30066006	T	T	30066006	3	4	206	1	0	0	0	0	1	0	0	0	5936	768	27	1	532	1	FKBP14	7	30066006	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	14340302	30066006	129072657	58	37633											
ELMO1	9844	broad.mit.edu	37	chr7	36895309	36895309	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccgcgtcaggtcgctcatCatgtccttcccgagtagcgc	5	11	10	15	5	3	0	3	0	0	0	7	1	6	0	3	1	1	2	3	1	1	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr7:36895309C>T	uc003tfk.1	-	22	2338	c.2031G>A	c.(2029-2031)ATG>ATA	p.M677I	ELMO1_uc003tfi.1_Missense_Mutation_p.M197I|ELMO1_uc003tfj.1_Missense_Mutation_p.M197I|ELMO1_uc011kbb.1_RNA|ELMO1_uc011kbc.1_Missense_Mutation_p.M581I|ELMO1_uc010kxg.1_Missense_Mutation_p.M677I	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	677					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GGTCGCTCATCATGTCCTTCC	0.542													38	150					0	0	0	0	T	36895309	T	T	36895309	3	4	206	1	0	0	0	0	1	0	0	0	5089	826	29	2	156	2	ELMO1	7	36895309	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	6829303	36895309	122243354	59	37634											
ZNF479	90827	broad.mit.edu	37	chr7	57188597	57188597	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttccagtatatcttgttttAtctctattggaatttgaaaa	11	20	5	5	0	2	1	0	1	2	0	4	2	3	2	1	1	0	2	1	1	7	9			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr7:57188597A>G	uc010kzo.2	-	5	796	c.525T>C	c.(523-525)GAT>GAC	p.D175D		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			ATCTTGTTTTATCTCTATTGG	0.279													18	40					0	0	0	0	G	57188597	G	G	57188597	2	3	206	1	0	0	0	0	0	0	0	1	18000	446	16	5		5	ZNF479	7	57188597	Silent	SNP	A	TCGA-CV-6951-01A-11D-1912-08	20293288	57188597	101950066	60	37635											
PTPN12	5782	broad.mit.edu	37	chr7	77256506	77256506	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actgcagtgtaacacaatcaAacaaagtttcagttactcca	16	10	5	10	0	2	0	2	0	0	0	3	0	3	0	1	0	4	4	1	0	5	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr7:77256506A>G	uc003ugh.2	+	13	1601	c.1510A>G	c.(1510-1512)AAC>GAC	p.N504D	PTPN12_uc011kgp.1_Missense_Mutation_p.N385D|PTPN12_uc011kgq.1_Missense_Mutation_p.N374D|PTPN12_uc010lds.2_Missense_Mutation_p.N236D	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	504						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						AACACAATCAAACAAAGTTTC	0.428													8	52					0	0	0	0	G	77256506	G	G	77256506	3	3	206	1	0	0	0	0	1	0	0	0	12844	14	1	5	1560	5	PTPN12	7	77256506	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08	20067909	77256506	81882157	61	37636											
ZNF804B	219578	broad.mit.edu	37	chr7	88963135	88963135	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaccttaccaaggaaaaagAggtaaatatctcaccaagcc	18	6	6	11	0	1	1	1	0	1	1	2	2	1	2	4	2	2	1	4	2	8	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr7:88963135A>C	uc011khi.1	+	4	1377	c.839A>C	c.(838-840)GAG>GCG	p.E280A		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	280						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AAGGAAAAAGAGGTAAATATC	0.358										HNSCC(36;0.09)			11	39					0	0	0	0	C	88963135	C	C	88963135	3	2	206	1	0	0	0	0	1	0	0	0	18238	304	11	5	853	5	ZNF804B	7	88963135	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08	11706629	88963135	70175528	62	37637											
SAMD9L	219285	broad.mit.edu	37	chr7	92761451	92761451	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttgggtatacctcattttCagaagaaccatataatcaat	14	15	5	7	0	3	2	3	0	0	2	3	2	3	2	2	1	2	1	2	1	7	8			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr7:92761451C>T	uc003umh.1	-	5	5050	c.3834G>A	c.(3832-3834)CTG>CTA	p.L1278L	SAMD9L_uc003umj.1_Silent_p.L1278L|SAMD9L_uc003umi.1_Silent_p.L1278L|SAMD9L_uc010lfb.1_Silent_p.L1278L|SAMD9L_uc003umk.1_Silent_p.L1278L|SAMD9L_uc010lfc.1_Silent_p.L1278L|SAMD9L_uc010lfd.1_Silent_p.L1278L|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1278										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			ACCTCATTTTCAGAAGAACCA	0.328													16	61					0	0	0	0	T	92761451	T	T	92761451	2	4	206	1	0	0	0	0	0	0	0	1	13892	813	29	2		2	SAMD9L	7	92761451	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	3798316	92761451	66377212	63	37638											
EPHB4	2050	broad.mit.edu	37	chr7	100420076	100420076	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagctcccgaggcacagtctCcgggaatcgagtcaggttca	9	7	12	13	3	3	0	2	0	1	0	6	3	4	1	2	3	1	3	2	3	1	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr7:100420076C>T	uc003uwn.1	-	4	1116	c.625G>A	c.(625-627)GAG>AAG	p.E209K	EPHB4_uc003uwm.1_Missense_Mutation_p.E116K|EPHB4_uc010lhj.1_Missense_Mutation_p.E209K|EPHB4_uc011kkf.1_Missense_Mutation_p.E209K|EPHB4_uc011kkg.1_Missense_Mutation_p.E209K|EPHB4_uc011kkh.1_Missense_Mutation_p.E209K	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	209	Extracellular (Potential).|Cys-rich.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGCACAGTCTCCGGGAATCGA	0.657													11	31					0	0	0	0	T	100420076	T	T	100420076	3	4	206	1	0	0	0	0	1	0	0	0	5201	864	30	2	2394	2	EPHB4	7	100420076	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	7658625	100420076	58718587	64	37639											
PPP1R3A	5506	broad.mit.edu	37	chr7	113519867	113519867	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgccagtatgtaattgcactAgttcatcactactagtatct	11	15	6	9	0	3	0	2	0	1	0	3	0	3	0	1	0	3	5	1	0	6	8			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr7:113519867A>G	uc010ljy.1	-	4	1311	c.1280T>C	c.(1279-1281)CTA>CCA	p.L427P		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	427					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TAATTGCACTAGTTCATCACT	0.428													85	62					0	0	0	0	G	113519867	G	G	113519867	3	3	206	1	0	0	0	0	1	0	0	0	12431	420	15	5	2092	5	PPP1R3A	7	113519867	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08	13099791	113519867	45618796	65	37640											
CTTNBP2	83992	broad.mit.edu	37	chr7	117450885	117450885	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcttgcattttcttgcagtgGgccatgactgcttcaaggat	7	15	10	9	0	3	1	1	1	2	0	3	2	3	2	1	2	3	3	1	2	1	5			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr7:117450885G>A	uc003vjf.2	-	3	440	c.348C>T	c.(346-348)GCC>GCT	p.A116A		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	116										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TCTTGCAGTGGGCCATGACTG	0.507													47	217					0	0	0	0	A	117450885	A	A	117450885	2	1	206	1	0	0	0	0	0	0	0	1	4062	1219	43	4		4	CTTNBP2	7	117450885	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08	3931018	117450885	41687778	66	37641											
TG	7038	broad.mit.edu	37	chr8	133898695	133898695	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcactttgtctcatgcagctGaaggccaatcttgtgcctcc	7	13	8	13	0	3	1	2	1	2	0	5	1	4	1	3	1	3	2	3	1	2	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr8:133898695G>T	uc003ytw.2	+	9	1119	c.1078G>T	c.(1078-1080)GAA>TAA	p.E360*		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	360					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCATGCAGCTGAAGGCCAATC	0.493													50	98					3.86236e-30	1.15359e-29	1	0	T	133898695	T	T	133898695	4	4	206	1	0	0	0	0	0	1	0	0	15879	1291	45	2	1112	2	TG	8	133898695	Nonsense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08		133898695	12465327	67	37642											
TIGD5	84948	broad.mit.edu	37	chr8	144681367	144681367	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaaacagctgtacaagcgcGagctgctgcgactggctgtg	9	8	13	11	3	1	0	1	0	0	0	1	2	1	0	0	1	7	5	0	1	3	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr8:144681367G>A	uc003yyx.1	+	1	1147	c.1147G>A	c.(1147-1149)GAG>AAG	p.E383K	EEF1D_uc011lki.1_5'Flank|EEF1D_uc011lkj.1_5'Flank|EEF1D_uc003yyr.2_5'Flank|EEF1D_uc003yyt.2_5'Flank|EEF1D_uc011lkk.1_5'Flank|EEF1D_uc003yys.2_5'Flank|EEF1D_uc003yyv.2_5'Flank|EEF1D_uc003yyu.2_5'Flank|EEF1D_uc011lkl.1_5'Flank	NM_032862	NP_116251	Q53EQ6	TIGD5_HUMAN	tigger transposable element derived 5	432					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GTACAAGCGCGAGCTGCTGCG	0.647													10	28					0	0	0	0	A	144681367	A	A	144681367	3	1	206	1	0	0	0	0	1	0	0	0	15965	1059	37	1	1296	1	TIGD5	8	144681367	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	10782672	144681367	1682655	68	37643											
MAPK15	225689	broad.mit.edu	37	chr8	144801638	144801638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcctggagaccatcccacCgccatctgaggagggtgagc	9	6	13	13	1	1	3	0	2	1	1	3	6	3	4	5	3	1	0	5	3	0	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr8:144801638C>T	uc003yzj.2	+	7	748	c.707C>T	c.(706-708)CCG>CTG	p.P236L		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	236	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			ACCATCCCACCGCCATCTGAG	0.657													26	28					0	0	0	0	T	144801638	T	T	144801638	3	4	206	1	0	0	0	0	1	0	0	0	9330	652	23	1	733	1	MAPK15	8	144801638	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	120271	144801638	1562384	69	37644											
EPPK1	83481	broad.mit.edu	37	chr8	144942354	144942354	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtgcacggggtcgatgaTgccgcccgtggcgatctggg	4	8	18	11	5	1	1	0	1	1	0	2	3	1	1	2	4	2	2	2	4	0	0	rs113992087		TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr8:144942354T>C	uc003zaa.1	-	1	5081	c.5068A>G	c.(5068-5070)ATC>GTC	p.I1690V		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1690	Plectin 29.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGTCGATGATGCCGCCCGTG	0.677													14	114					0	0	0	0	C	144942354	C	C	144942354	3	2	206	1	0	0	0	0	1	0	0	0	5214	1464	51	5	2198	5	EPPK1	8	144942354	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08	140716	144942354	1421668	70	37645											
PLEC	5339	broad.mit.edu	37	chr8	145012852	145012852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggttttcttctgcacacgatCccgctcatctgggggagaca	7	11	11	12	2	4	1	1	0	3	1	5	3	5	1	1	3	1	3	1	3	0	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr8:145012852C>T	uc003zaf.1	-	2	702	c.532G>A	c.(532-534)GAT>AAT	p.D178N	PLEC_uc003zab.1_Missense_Mutation_p.D41N|PLEC_uc003zac.1_Missense_Mutation_p.D45N|PLEC_uc003zad.2_Missense_Mutation_p.D41N|PLEC_uc003zae.1_Missense_Mutation_p.D9N|PLEC_uc003zag.1_Missense_Mutation_p.D19N|PLEC_uc003zah.2_Missense_Mutation_p.D27N|PLEC_uc003zaj.2_Missense_Mutation_p.D68N	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	178	Globular 1.|Actin-binding.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TGCACACGATCCCGCTCATCT	0.627													20	67					0	0	0	0	T	145012852	T	T	145012852	3	4	206	1	0	0	0	0	1	0	0	0	12107	855	30	2	13646	2	PLEC	8	145012852	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	70498	145012852	1351170	71	37646											
CPSF1	29894	broad.mit.edu	37	chr8	145624248	145624248	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggttgtcaccacctggggcCggatgctcttctagaatgat	8	11	12	10	1	3	2	1	1	2	1	3	3	3	3	3	4	1	2	3	4	2	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr8:145624248C>T	uc003zcj.2	-	17	1634	c.1559G>A	c.(1558-1560)CGG>CAG	p.R520Q		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	520					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CACCTGGGGCCGGATGCTCTT	0.642													97	85					0	0	0	0	T	145624248	T	T	145624248	3	4	206	1	0	0	0	0	1	0	0	0	3839	652	23	1	2860	1	CPSF1	8	145624248	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	611396	145624248	739774	72	37647											
PSIP1	11168	broad.mit.edu	37	chr9	15472704	15472705	+	Frame_Shift_Ins	INS	-	T	T																															catgttggcctttcagcataINSttccttctgtgagcagtctg																										TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr9:15472704_15472705insT	uc003zlv.3	-	10	1232_1233	c.902_903insA	c.(901-903)AATfs	p.N301fs	PSIP1_uc003zlw.3_Frame_Shift_Ins_p.N301fs|PSIP1_uc003zlz.3_Frame_Shift_Ins_p.N301fs|PSIP1_uc003zma.3_Frame_Shift_Ins_p.N292fs|PSIP1_uc003zly.2_Frame_Shift_Ins_p.N301fs	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	301					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		CTTTCAGCATATTCCTTCTGTG	0.361													---	---	---								T	15472705	T	T	15472704	7	5	206	1	0	1	1	0	0	0	0	0	12725	446	16	0	746	0	PSIP1	9	15472704	Frame_Shift_Ins	INS	-	TCGA-CV-6951-01A-11D-1912-08		15472704	125740727	73	37648											
CDKN2A	1029	broad.mit.edu	37	chr9	21970919	21970919	+	Frame_Shift_Del	DEL	C	-	-																															acctgagggaccttccgcggCatctatgcgggcatggttac																										TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr9:21970919delC	uc003zpk.2	-	2	651	c.439delG	c.(439-441)GCCfs	p.A147fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	147					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.R128fs*12(3)|p.A147A(2)|p.A147T(2)|p.A118fs*10(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCTTCCGCGGCATCTATGCGG	0.597		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---								-	21970919	-	-	21970919	7	5	206	1	0	1	0	1	0	0	0	0	3176	710	25	0	39	0	CDKN2A	9	21970919	Frame_Shift_Del	DEL	C	TCGA-CV-6951-01A-11D-1912-08	6498215	21970919	119242512	74	37649											
DNAJA1	3301	broad.mit.edu	37	chr9	33034296	33034296	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaggcgatattatcattgtGttagatcagaaggaccatgc	12	11	10	8	1	2	2	2	0	0	2	2	4	2	3	2	2	1	1	2	2	4	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr9:33034296G>T	uc003zsd.1	+	6	909	c.726G>T	c.(724-726)GTG>GTT	p.V242V	DNAJA1_uc011lnt.1_Silent_p.V85V|DNAJA1_uc003zse.1_Silent_p.V242V	NM_001539	NP_001530	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	242					protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		TTATCATTGTGTTAGATCAGA	0.368													13	26					5.50884e-06	1.46146e-05	1	0	T	33034296	T	T	33034296	2	4	206	1	0	0	0	0	0	0	0	1	4633	1364	48	4		4	DNAJA1	9	33034296	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08	11063377	33034296	108179135	75	37650											
PTAR1	375743	broad.mit.edu	37	chr9	72338400	72338400	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actagggctggctcacttctCaaaggattttgctccatcac	9	12	8	12	0	3	0	3	0	1	0	5	1	4	1	1	3	1	3	1	3	2	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr9:72338400C>G	uc004ahj.3	-	6	811	c.789G>C	c.(787-789)TTG>TTC	p.L263F	PTAR1_uc004ahi.2_Missense_Mutation_p.L184F	NM_001099666	NP_001093136	Q7Z6K3	PTAR1_HUMAN	protein prenyltransferase alpha subunit repeat	263					protein prenylation		protein prenyltransferase activity			central_nervous_system(1)	1						GCTCACTTCTCAAAGGATTTT	0.423													19	53					0	0	0	0	G	72338400	G	G	72338400	3	3	206	1	0	0	0	0	1	0	0	0	12786	825	29	2	431	2	PTAR1	9	72338400	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	39304104	72338400	68875031	76	37651											
TRPM3	80036	broad.mit.edu	37	chr9	73167793	73167793	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctttcatccgggtcgctctCgtgtttcctccatcggcagc	3	13	9	16	4	2	0	1	0	1	0	8	0	5	0	4	2	1	3	4	2	0	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr9:73167793C>T	uc004aid.2	-	23	3749	c.3505G>A	c.(3505-3507)GAG>AAG	p.E1169K	TRPM3_uc004ahu.2_Missense_Mutation_p.E1011K|TRPM3_uc004ahv.2_Missense_Mutation_p.E971K|TRPM3_uc004ahw.2_Missense_Mutation_p.E1041K|TRPM3_uc004ahx.2_Missense_Mutation_p.E1028K|TRPM3_uc004ahy.2_Missense_Mutation_p.E1031K|TRPM3_uc004ahz.2_Missense_Mutation_p.E1018K|TRPM3_uc004aia.2_Missense_Mutation_p.E1016K|TRPM3_uc004aib.2_Missense_Mutation_p.E1006K|TRPM3_uc004aic.2_Missense_Mutation_p.E1169K	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1194	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						GGGTCGCTCTCGTGTTTCCTC	0.527													66	170					0	0	0	0	T	73167793	T	T	73167793	3	4	206	1	0	0	0	0	1	0	0	0	16654	893	31	1	1630	1	TRPM3	9	73167793	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	829393	73167793	68045638	77	37652											
PTCH1	5727	broad.mit.edu	37	chr9	98239882	98239882	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgagcacaggcccagtcCtgcagccactgacagtgcaa	12	5	10	14	0	0	2	0	2	0	0	1	2	1	2	3	1	4	3	3	1	2	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr9:98239882C>A	uc004avk.3	-	10	1638	c.1450G>T	c.(1450-1452)GGA>TGA	p.G484*	PTCH1_uc010mro.2_Nonsense_Mutation_p.G333*|PTCH1_uc010mrp.2_Nonsense_Mutation_p.G333*|PTCH1_uc010mrq.2_Nonsense_Mutation_p.G333*|PTCH1_uc004avl.3_Nonsense_Mutation_p.G333*|PTCH1_uc010mrr.2_Nonsense_Mutation_p.G418*|PTCH1_uc004avm.3_Nonsense_Mutation_p.G483*|PTCH1_uc010mrs.1_Intron	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	484	SSD.|Helical; (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.G484R(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AGGCCCAGTCCTGCAGCCACT	0.572									Basal_Cell_Nevus_syndrome				45	10					3.54909e-21	1.03267e-20	1	0	A	98239882	A	A	98239882	4	1	206	1	0	0	0	0	0	1	0	0	12792	690	24	4	2949	4	PTCH1	9	98239882	Nonsense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	25072089	98239882	42973549	78	37653											
ALG2	85365	broad.mit.edu	37	chr9	101980370	101980370	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgcttctgagaagtgcaccGggtcaggctcacacagaaac	11	8	11	11	1	3	2	2	1	1	2	3	3	3	2	1	2	3	3	1	2	2	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr9:101980370G>A	uc004azf.2	-	2	1167	c.1097C>T	c.(1096-1098)CCG>CTG	p.P366L	ALG2_uc004azg.2_Missense_Mutation_p.P273L	NM_033087	NP_149078	Q9H553	ALG2_HUMAN	alpha-1,3-mannosyltransferase ALG2	366					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.0559)				GAAGTGCACCGGGTCAGGCTC	0.502													26	59					0	0	0	0	A	101980370	A	A	101980370	3	1	206	1	0	0	0	0	1	0	0	0	519	1116	39	1	157	1	ALG2	9	101980370	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	3740488	101980370	39233061	79	37654											
C9orf4	23732	broad.mit.edu	37	chr9	111903702	111903702	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttcatctctgggaacattCacagggcgtttaaatctgca	10	13	9	9	1	4	0	2	0	2	0	5	1	4	1	0	2	2	3	0	2	3	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr9:111903702C>T	uc004bdw.1	-	4	783	c.783G>A	c.(781-783)GTG>GTA	p.V261V		NM_014334	NP_055149	Q9P0K9	CI004_HUMAN	hypothetical protein LOC23732	261	DOMON.					integral to membrane					0						TGGGAACATTCACAGGGCGTT	0.448													61	24					0	0	0	0	T	111903702	T	T	111903702	2	4	206	1	0	0	0	0	0	0	0	1	2492	813	29	2		2	C9orf4	9	111903702	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	9923332	111903702	29309729	80	37655											
SH2D3C	10044	broad.mit.edu	37	chr9	130536273	130536273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccctgggcacctacctttCtgagtgcacgtccctgggag	5	9	12	15	1	1	1	0	1	1	0	2	2	2	2	5	2	2	2	5	2	1	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr9:130536273C>T	uc004bsc.2	-	2	653	c.511G>A	c.(511-513)GAA>AAA	p.E171K	SH2D3C_uc004bsa.2_5'Flank|SH2D3C_uc004bsb.2_5'Flank|SH2D3C_uc004bsd.1_Missense_Mutation_p.E115K	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	171					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						ACCTACCTTTCTGAGTGCACG	0.448													31	12					0	0	0	0	T	130536273	T	T	130536273	3	4	206	1	0	0	0	0	1	0	0	0	14299	922	32	2	2248	2	SH2D3C	9	130536273	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	18632571	130536273	10677158	81	37656											
PPP2R4	5524	broad.mit.edu	37	chr9	131897100	131897100	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcagccttcgctgctttcCtctgctgtctctgcaagatt	5	14	9	13	1	2	1	0	0	2	1	5	1	3	1	2	1	4	5	2	1	1	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr9:131897100C>T	uc004bxm.1	+	7	859	c.592C>T	c.(592-594)CTC>TTC	p.L198F	PPP2R4_uc004bxl.1_Missense_Mutation_p.L163F|PPP2R4_uc011mbo.1_Missense_Mutation_p.L198F|PPP2R4_uc010myr.1_Intron|PPP2R4_uc004bxn.1_Missense_Mutation_p.L163F|PPP2R4_uc004bxo.1_Missense_Mutation_p.L121F|PPP2R4_uc011mbp.1_Missense_Mutation_p.L134F|PPP2R4_uc011mbq.1_Missense_Mutation_p.L121F|PPP2R4_uc010mys.1_Missense_Mutation_p.L128F	NM_178001	NP_821068	Q15257	PTPA_HUMAN	protein phosphatase 2A, regulatory subunit B'	198					ATP catabolic process|negative regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|positive regulation of apoptosis|positive regulation of phosphoprotein phosphatase activity|positive regulation of protein dephosphorylation	calcium channel complex|cytoplasm|nucleus|protein phosphatase type 2A complex|soluble fraction	ATP binding|peptidyl-prolyl cis-trans isomerase activity|protein heterodimerization activity|protein homodimerization activity|protein phosphatase 2A binding|protein phosphatase type 2A regulator activity|protein tyrosine phosphatase activator activity|receptor binding			ovary(1)|lung(1)|pancreas(1)	3		Medulloblastoma(224;0.235)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)		CGCTGCTTTCCTCTGCTGTCT	0.512													55	14					0	0	0	0	T	131897100	T	T	131897100	3	4	206	1	0	0	0	0	1	0	0	0	12451	681	24	4	618	4	PPP2R4	9	131897100	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	1360827	131897100	9316331	82	37657											
ZNF248	57209	broad.mit.edu	37	chr10	38120569	38120569	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgttgaaagagctttcacccTtgtgtgaattctctgatgtt	8	17	9	7	0	2	4	1	3	1	1	3	4	2	4	1	0	1	3	1	0	2	5			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr10:38120569T>C	uc001izd.1	-	6	2213	c.1714A>G	c.(1714-1716)AGG>GGG	p.R572G	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Missense_Mutation_p.R572G	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCTTTCACCCTTGTGTGAATT	0.423													10	38					0	0	0	0	C	38120569	C	C	38120569	3	2	206	1	0	0	0	0	1	0	0	0	17860	1608	56	5	29	5	ZNF248	10	38120569	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08		38120569	97414178	83	37658											
ZNF33B	7582	broad.mit.edu	37	chr10	43088343	43088343	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttctcccccgtgtgcttTctctcatgtaaaataagtcc	7	15	7	12	1	3	0	1	0	2	0	6	0	4	0	3	1	1	3	3	1	3	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr10:43088343T>C	uc001jaf.1	-	5	2170	c.2055A>G	c.(2053-2055)AGA>AGG	p.R685R	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Silent_p.R573R|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	685	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCGTGTGCTTTCTCTCATGTA	0.403													26	62					0	0	0	0	C	43088343	C	C	43088343	2	2	206	1	0	0	0	0	0	0	0	1	17922	1780	62	5		5	ZNF33B	10	43088343	Silent	SNP	T	TCGA-CV-6951-01A-11D-1912-08	4967774	43088343	92446404	84	37659											
KIAA0913	23053	broad.mit.edu	37	chr10	75556724	75556724	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaaccagggagtgtggcaGgggctgggccaggccccact	7	5	16	13	0	1	0	1	0	0	0	1	1	1	1	4	6	1	2	4	6	1	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr10:75556724G>T	uc009xrl.2	+	16	3243	c.3211G>T	c.(3211-3213)GGG>TGG	p.G1071W	KIAA0913_uc001jve.2_Missense_Mutation_p.G1076W|KIAA0913_uc001jvf.2_Missense_Mutation_p.G1071W|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.G506W|KIAA0913_uc010qkr.1_Missense_Mutation_p.G494W|KIAA0913_uc001jvj.2_Missense_Mutation_p.G494W|KIAA0913_uc009xrn.1_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	1071							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					GAGTGTGGCAGGGGCTGGGCC	0.647													11	37					0.000673444	0.00173556	1	0	T	75556724	T	T	75556724	3	4	206	1	0	0	0	0	1	0	0	0	8239	1000	35	4	3288	4	KIAA0913	10	75556724	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	32468381	75556724	59978023	85	37660											
SFTPA1	653509	broad.mit.edu	37	chr10	81373011	81373011	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttagacatcaaatcctgcAgacaaggggaggtaagggga	14	7	13	7	0	1	2	1	0	0	2	2	4	2	4	1	5	1	2	1	5	4	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr10:81373011A>G	uc001kap.2	+	5	480	c.359A>G	c.(358-360)CAG>CGG	p.Q120R	SFTPA1_uc001kaq.2_Missense_Mutation_p.Q120R|SFTPA1_uc009xry.2_Missense_Mutation_p.Q135R|SFTPA1_uc001kar.2_Missense_Mutation_p.Q120R|SFTPA1_uc010qlt.1_Missense_Mutation_p.Q61R|SFTPA1_uc009xrz.2_Missense_Mutation_p.Q50R|SFTPA1_uc009xsa.2_Missense_Mutation_p.Q120R|SFTPA1_uc009xsf.2_5'Flank	NM_005411	NP_005402	Q8IWL2	SFTA1_HUMAN	surfactant protein A1 isoform 1	120					cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			CAAATCCTGCAGACAAGGGGA	0.547													65	104					0	0	0	0	G	81373011	G	G	81373011	3	3	206	1	0	0	0	0	1	0	0	0	14254	188	7	5	418	5	SFTPA1	10	81373011	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08	5816287	81373011	54161736	86	37661											
TNKS2	80351	broad.mit.edu	37	chr10	93582061	93582061	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctcattgtagtgatctggTaccattacacaatgcctgtt	9	16	7	9	0	2	1	1	1	2	0	3	1	2	1	2	1	3	3	2	1	4	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr10:93582061T>A	uc001khp.2	+	7	1034	c.737T>A	c.(736-738)GTA>GAA	p.V246E		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	246	ANK 5.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				AGTGATCTGGTACCATTACAC	0.328													46	43					0	0	0	0	A	93582061	A	A	93582061	3	1	206	1	0	0	0	0	1	0	0	0	16387	1638	57	5	763	5	TNKS2	10	93582061	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08	12209050	93582061	41952686	87	37662											
RAB11FIP2	22841	broad.mit.edu	37	chr10	119799785	119799785	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcgctgaggacccaagagAaaaggcttttttggtttgga	11	11	13	6	1	0	2	0	1	0	1	1	5	0	4	1	4	0	3	1	4	3	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr10:119799785A>G	uc001ldj.1	-	2	1085	c.645T>C	c.(643-645)TTT>TTC	p.F215F	RAB11FIP2_uc009xyz.1_Silent_p.F215F	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	215					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		GACCCAAGAGAAAAGGCTTTT	0.433													22	67					0	0	0	0	G	119799785	G	G	119799785	2	3	206	1	0	0	0	0	0	0	0	1	12959	243	9	5		5	RAB11FIP2	10	119799785	Silent	SNP	A	TCGA-CV-6951-01A-11D-1912-08	26217724	119799785	15734962	88	37663											
DMBT1	1755	broad.mit.edu	37	chr10	124348656	124348656	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgcccggtttggtcagggCtcaggacccattgtcctgga	7	10	13	11	1	2	0	2	0	0	0	3	2	3	2	3	5	1	2	3	5	1	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr10:124348656C>T	uc001lgk.1	+	17	2086	c.1980C>T	c.(1978-1980)GGC>GGT	p.G660G	DMBT1_uc001lgl.1_Silent_p.G650G|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Silent_p.G660G|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Intron	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	660	SRCR 5.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTGGTCAGGGCTCAGGACCCA	0.602													58	158					0	0	0	0	T	124348656	T	T	124348656	2	4	206	1	0	0	0	0	0	0	0	1	4599	784	28	4		4	DMBT1	10	124348656	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	4548871	124348656	11186091	89	37664											
MUC5B	727897	broad.mit.edu	37	chr11	1263375	1263375	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacgagcgagctgtccacCtctcaggccgagaccagcac	9	5	10	17	3	2	1	2	0	1	1	4	4	3	1	4	1	3	2	4	1	0	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr11:1263375C>T	uc009ycr.1	+	47	7470	c.7344C>T	c.(7342-7344)ACC>ACT	p.T2448T	MUC5B_uc001ltb.2_Silent_p.T1758T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1755	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGCTGTCCACCTCTCAGGCCG	0.642													9	23					0	0	0	0	T	1263375	T	T	1263375	2	4	206	1	0	0	0	0	0	0	0	1	10032	668	24	4		4	MUC5B	11	1263375	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08		1263375	133743141	90	37665											
SCUBE2	57758	broad.mit.edu	37	chr11	9080855	9080855	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttcagcacataccttggCaagacttctcatctgttaat	10	15	6	10	0	3	1	2	0	2	1	4	1	3	1	1	1	2	4	1	1	3	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr11:9080855C>G	uc001mhh.1	-	9	1165	c.1085G>C	c.(1084-1086)TGC>TCC	p.C362S	SCUBE2_uc001mhi.1_Missense_Mutation_p.C362S|SCUBE2_uc001mhj.1_Missense_Mutation_p.C362S	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	362	EGF-like 7; calcium-binding (Potential).					extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		CATACCTTGGCAAGACTTCTC	0.483													8	38					0	0	0	0	G	9080855	G	G	9080855	3	3	206	1	0	0	0	0	1	0	0	0	14010	710	25	4	2061	4	SCUBE2	11	9080855	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	7817480	9080855	125925661	91	37666											
CHST1	8534	broad.mit.edu	37	chr11	45671418	45671418	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctcggccgtggccgccgaGtttcgcacggtgccgtattt	3	12	13	13	7	1	0	0	0	1	0	3	1	1	0	4	3	1	3	4	3	1	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr11:45671418G>C	uc001mys.1	-	4	1727	c.1056C>G	c.(1054-1056)AAC>AAG	p.N352K		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	352	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		TGGCCGCCGAGTTTCGCACGG	0.672													47	42					0	0	0	0	C	45671418	C	C	45671418	3	2	206	1	0	0	0	0	1	0	0	0	3412	1020	36	4	183	4	CHST1	11	45671418	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	36590563	45671418	89335098	92	37667											
OR8I2	120586	broad.mit.edu	37	chr11	55861217	55861217	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaaagtgtccaactggctggGagtaatgccatatgtgatag	13	10	12	6	0	0	1	0	1	0	0	1	2	1	2	2	2	2	2	2	2	6	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr11:55861217G>C	uc010rix.1	+	1	434	c.434G>C	c.(433-435)GGA>GCA	p.G145A		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					AACTGGCTGGGAGTAATGCCA	0.433													45	52					0	0	0	0	C	55861217	C	C	55861217	3	2	206	1	0	0	0	0	1	0	0	0	11294	1174	41	2	436	2	OR8I2	11	55861217	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	10189799	55861217	79145299	93	37668											
EHD1	10938	broad.mit.edu	37	chr11	64622855	64622855	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctcgcgctcaatcttcTggtagatctctccgaggttg	5	13	12	11	3	4	1	1	0	3	1	7	2	5	1	1	3	1	4	1	3	2	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr11:64622855T>C	uc001obu.1	-	4	1274	c.1019A>G	c.(1018-1020)CAG>CGG	p.Q340R	EHD1_uc001obt.1_Missense_Mutation_p.Q23R|EHD1_uc001obv.1_Missense_Mutation_p.Q340R|EHD1_uc010rnq.1_Missense_Mutation_p.Q354R	NM_006795	NP_006786	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	340					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding				0						CTCAATCTTCTGGTAGATCTC	0.557											OREG0004024	type=REGULATORY REGION|Gene=EHD1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	22	72					0	0	0	0	C	64622855	C	C	64622855	3	2	206	1	0	0	0	0	1	0	0	0	4999	1580	55	5	593	5	EHD1	11	64622855	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08	8761638	64622855	70383661	94	37669											
SAPS3	55291	broad.mit.edu	37	chr11	68318642	68318642	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggaaatagttcatccatcGcaagaagaagatgtaagttc	15	10	10	6	1	1	3	1	0	0	3	4	4	2	4	1	1	0	4	1	1	6	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr11:68318642G>T	uc001onw.2	+	6	873	c.606G>T	c.(604-606)TCG>TCT	p.S202S	SAPS3_uc010rqb.1_Silent_p.S111S|SAPS3_uc001onv.2_Silent_p.S202S|SAPS3_uc001ony.3_Silent_p.S202S|SAPS3_uc001onx.2_Silent_p.S202S|SAPS3_uc009ysh.2_Silent_p.S202S|SAPS3_uc001onu.2_Silent_p.S202S|SAPS3_uc010rqc.1_Intron	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	202					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			TTCATCCATCGCAAGAAGAAG	0.333													15	50					7.93312e-07	2.15532e-06	1	0	T	68318642	T	T	68318642	2	4	206	1	0	0	0	0	0	0	0	1	13903	1074	38	3		3	SAPS3	11	68318642	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08	3695787	68318642	66687874	95	37670											
P2RY2	5029	broad.mit.edu	37	chr11	72945507	72945507	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcggcgaccactggcccttCagcacggtgctctgcaagct	6	7	12	16	4	2	0	1	0	1	0	2	1	2	0	2	3	4	4	2	3	1	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr11:72945507C>T	uc001otj.2	+	3	636	c.303C>T	c.(301-303)TTC>TTT	p.F101F	P2RY2_uc001otk.2_Silent_p.F101F|P2RY2_uc001otl.2_Silent_p.F101F	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	101	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	ACTGGCCCTTCAGCACGGTGC	0.597													21	96					0	0	0	0	T	72945507	T	T	72945507	2	4	206	1	0	0	0	0	0	0	0	1	11406	825	29	2		2	P2RY2	11	72945507	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	4626865	72945507	62061009	96	37671											
OR2AT4	341152	broad.mit.edu	37	chr11	74800310	74800310	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttagccaggcactggctGccaaggtagcattggtctgt	8	10	13	10	0	1	0	0	0	1	0	1	0	1	0	2	4	3	5	2	4	3	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr11:74800310G>A	uc010rro.1	-	1	449	c.449C>T	c.(448-450)GCA>GTA	p.A150V		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGCACTGGCTGCCAAGGTAGC	0.557													47	57					0	0	0	0	A	74800310	A	A	74800310	3	1	206	1	0	0	0	0	1	0	0	0	11041	1319	46	4	516	4	OR2AT4	11	74800310	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	1854803	74800310	60206206	97	37672											
GAB2	9846	broad.mit.edu	37	chr11	77931466	77931466	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actgttcgtgccactgggaaCgggagatgcagacactgggt	9	8	15	9	2	0	2	0	0	0	2	1	4	0	3	1	3	3	2	1	3	1	1	rs145573768		TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr11:77931466C>T	uc001ozh.2	-	9	1786	c.1786G>A	c.(1786-1788)GTT>ATT	p.V596I	GAB2_uc001ozg.2_Missense_Mutation_p.V558I	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	596					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			CCACTGGGAACGGGAGATGCA	0.562													10	43					0	0	0	0	T	77931466	T	T	77931466	3	4	206	1	0	0	0	0	1	0	0	0	6183	536	19	1	252	1	GAB2	11	77931466	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	3131156	77931466	57075050	98	37673											
TYR	7299	broad.mit.edu	37	chr11	89018057	89018057	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccttttataccactgtacaGaaatggtgatttctttattt	10	19	5	7	0	1	2	0	1	1	1	2	2	2	2	2	1	2	1	2	1	5	8			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr11:89018057G>C	uc001pcs.2	+	4	1383	c.1301G>C	c.(1300-1302)AGA>ACA	p.R434T		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	434	Lumenal, melanosome (Potential).		R -> I (in OCA1A).		eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	CCACTGTACAGAAATGGTGAT	0.403									Oculocutaneous_Albinism				17	44					0	0	0	0	C	89018057	C	C	89018057	3	2	206	1	0	0	0	0	1	0	0	0	16881	942	33	2	1315	2	TYR	11	89018057	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	11086591	89018057	45988459	99	37674											
PZP	5858	broad.mit.edu	37	chr12	9307283	9307283	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaatgttagttgcagaggTcaggtcccctgaggtggggg	8	9	16	8	0	1	2	1	1	0	1	2	2	2	2	2	5	1	3	2	5	2	2	rs140597579	byFrequency	TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr12:9307283T>A	uc001qvl.2	-	29	3732	c.3703A>T	c.(3703-3705)ACC>TCC	p.T1235S	PZP_uc009zgl.2_Missense_Mutation_p.T1021S	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						GTTGCAGAGGTCAGGTCCCCT	0.557													24	38					0	0	0	0	A	9307283	A	A	9307283	3	1	206	1	0	0	0	0	1	0	0	0	12934	1667	58	5	777	5	PZP	12	9307283	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08		9307283	124544612	100	37675											
DHH	50846	broad.mit.edu	37	chr12	49488008	49488008	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttacctcggtcatcaggcgGtcggctccactgttctcctc	4	12	9	16	3	3	0	2	0	1	0	8	0	4	0	3	4	1	2	3	4	1	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr12:49488008G>A	uc001rtf.2	-	1	595	c.288C>T	c.(286-288)GAC>GAT	p.D96D		NM_021044	NP_066382	O43323	DHH_HUMAN	desert hedgehog preproprotein	96					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			lung(1)|breast(1)	2						TCATCAGGCGGTCGGCTCCAC	0.642													20	40					0	0	0	0	A	49488008	A	A	49488008	2	1	206	1	0	0	0	0	0	0	0	1	4505	1252	44	4		4	DHH	12	49488008	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08	40180725	49488008	84363887	101	37676											
SP7	121340	broad.mit.edu	37	chr12	53722831	53722831	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaggagccataggggtgtGtcatgtccagagaggtgtag	10	8	16	7	0	1	1	1	0	0	1	2	3	2	2	3	4	1	1	3	4	2	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr12:53722831G>T	uc001sct.2	-	2	502	c.395C>A	c.(394-396)ACA>AAA	p.T132K	SP7_uc001scu.2_Missense_Mutation_p.T114K|SP7_uc001scv.2_Missense_Mutation_p.T132K	NM_152860	NP_690599	Q8TDD2	SP7_HUMAN	osterix	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATAGGGGTGTGTCATGTCCAG	0.602													16	40					2.23348e-06	5.96036e-06	1	0	T	53722831	T	T	53722831	3	4	206	1	0	0	0	0	1	0	0	0	15033	1377	48	4	904	4	SP7	12	53722831	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	4234823	53722831	80129064	102	37677											
MON2	23041	broad.mit.edu	37	chr12	62954421	62954421	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agactcagataagcctgagaCaccacctgtagttaatgtac	14	9	8	10	0	1	3	1	1	0	3	1	4	1	3	3	0	2	3	3	0	4	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr12:62954421C>T	uc001sre.2	+	26	3951	c.3560C>T	c.(3559-3561)ACA>ATA	p.T1187I	MON2_uc009zqj.2_Missense_Mutation_p.T1187I|MON2_uc010ssl.1_Missense_Mutation_p.T1115I|MON2_uc010ssm.1_Missense_Mutation_p.T1164I|MON2_uc010ssn.1_Missense_Mutation_p.T1187I|MON2_uc001srf.2_Missense_Mutation_p.T950I|MON2_uc001srg.2_Missense_Mutation_p.T62I	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1188					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		AAGCCTGAGACACCACCTGTA	0.443													15	32					0	0	0	0	T	62954421	T	T	62954421	3	4	206	1	0	0	0	0	1	0	0	0	9753	478	17	4	3662	4	MON2	12	62954421	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	9231590	62954421	70897474	103	37678											
LRRIQ1	84125	broad.mit.edu	37	chr12	85623415	85623415	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgaaacgactagttccaGaaatatgaaatggtgaggtc	15	10	10	6	1	1	4	1	3	0	1	3	5	2	4	1	2	1	1	1	2	5	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr12:85623415G>T	uc001tac.2	+	25	5054	c.4943G>T	c.(4942-4944)AGA>ATA	p.R1648I		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1648										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ACTAGTTCCAGAAATATGAAA	0.338													9	49					1.58986e-06	4.26803e-06	1	0	T	85623415	T	T	85623415	3	4	206	1	0	0	0	0	1	0	0	0	9079	942	33	2	5041	2	LRRIQ1	12	85623415	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	22668994	85623415	48228480	104	37679											
MYBPC1	4604	broad.mit.edu	37	chr12	102030483	102030483	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggatgcaggagaacttgaCtttagtggtctcctgaaacg	11	10	13	7	1	1	3	0	2	1	1	2	6	1	4	1	3	3	1	1	3	3	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr12:102030483C>T	uc001tii.2	+	8	669	c.567C>T	c.(565-567)GAC>GAT	p.D189D	MYBPC1_uc001tif.1_Silent_p.D202D|MYBPC1_uc001tig.2_Silent_p.D214D|MYBPC1_uc010svq.1_Silent_p.D176D|MYBPC1_uc001tih.2_Silent_p.D214D|MYBPC1_uc001tij.2_Silent_p.D189D|MYBPC1_uc010svr.1_Silent_p.D189D|MYBPC1_uc010svs.1_Silent_p.D189D|MYBPC1_uc010svt.1_Silent_p.D177D|MYBPC1_uc010svu.1_Intron|MYBPC1_uc001tik.2_Silent_p.D163D	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	189					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GAGAACTTGACTTTAGTGGTC	0.428													7	21					0	0	0	0	T	102030483	T	T	102030483	2	4	206	1	0	0	0	0	0	0	0	1	10064	564	20	4		4	MYBPC1	12	102030483	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	16407068	102030483	31821412	105	37680											
TMEM116	89894	broad.mit.edu	37	chr12	112369498	112369498	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaagcccctgctatagaatCtcttctgtgagcataataat	12	14	6	9	0	2	2	0	1	2	1	3	2	2	2	2	0	3	2	2	0	6	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr12:112369498C>G	uc001ttc.1	-	13	1321	c.665G>C	c.(664-666)AGA>ACA	p.R222T	TMEM116_uc001ttd.1_Missense_Mutation_p.R314T|TMEM116_uc001tte.1_Missense_Mutation_p.R279T|TMEM116_uc001ttf.1_Missense_Mutation_p.R222T|TMEM116_uc001ttg.1_RNA|TMEM116_uc001tth.1_Missense_Mutation_p.R128T	NM_138341	NP_612350	Q8NCL8	TM116_HUMAN	transmembrane protein 116	222						integral to membrane				ovary(1)	1						GCTATAGAATCTCTTCTGTGA	0.453													22	64					0	0	0	0	G	112369498	G	G	112369498	3	3	206	1	0	0	0	0	1	0	0	0	16096	913	32	2	76	2	TMEM116	12	112369498	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	10339015	112369498	21482397	106	37681											
KNTC1	9735	broad.mit.edu	37	chr12	123019279	123019279	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attattgtagccgaccaatcAgtgatattgcttgacagtat	12	14	8	7	1	1	2	1	2	0	0	1	3	1	2	2	0	2	3	2	0	5	7			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr12:123019279A>G	uc001ucv.2	+	3	361	c.198A>G	c.(196-198)TCA>TCG	p.S66S	KNTC1_uc010taf.1_Silent_p.S66S	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	66					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CCGACCAATCAGTGATATTGC	0.353													3	21					0	0	0	0	G	123019279	G	G	123019279	2	3	206	1	0	0	0	0	0	0	0	1	8467	175	7	5		5	KNTC1	12	123019279	Silent	SNP	A	TCGA-CV-6951-01A-11D-1912-08	10649781	123019279	10832616	107	37682											
GRTP1	79774	broad.mit.edu	37	chr13	114009696	114009696	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccctggagaagctggtggtaGtagccgggattctggtccat	7	10	15	9	1	1	1	0	0	1	1	2	3	2	2	3	5	2	3	3	5	3	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr13:114009696G>C	uc001vtn.2	-	3	379	c.282C>G	c.(280-282)TAC>TAG	p.Y94*	GRTP1_uc010tkb.1_Nonsense_Mutation_p.Y16*|GRTP1_uc010tkc.1_Nonsense_Mutation_p.Y94*|GRTP1_uc010agv.1_RNA	NM_024719	NP_078995	Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	94	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GCTGGTGGTAGTAGCCGGGAT	0.672													42	6					0	0	0	0	C	114009696	C	C	114009696	4	2	206	1	0	0	0	0	0	1	0	0	6849	1024	36	4	752	4	GRTP1	13	114009696	Nonsense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08		114009696	1160182	108	37683											
SCFD1	23256	broad.mit.edu	37	chr14	31139469	31139469	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactttttcctaggatttccAtttaaacagggttaatttgg	10	18	7	6	0	0	0	0	0	0	0	2	1	2	1	2	3	2	1	2	3	5	9			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr14:31139469A>G	uc001wqm.1	+	11	887	c.863A>G	c.(862-864)CAT>CGT	p.H288R	SCFD1_uc001wqn.1_Missense_Mutation_p.H221R|SCFD1_uc010tpg.1_Missense_Mutation_p.H229R|SCFD1_uc010tph.1_Missense_Mutation_p.H103R|SCFD1_uc010amf.1_Missense_Mutation_p.H103R|SCFD1_uc010tpi.1_Missense_Mutation_p.H196R|SCFD1_uc010amd.1_Missense_Mutation_p.H120R|SCFD1_uc010ame.1_Missense_Mutation_p.H221R	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	288					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		TAGGATTTCCATTTAAACAGG	0.338													72	140					0	0	0	0	G	31139469	G	G	31139469	3	3	206	1	0	0	0	0	1	0	0	0	13954	217	8	5	905	5	SCFD1	14	31139469	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08		31139469	76210071	109	37684											
SLC8A3	6547	broad.mit.edu	37	chr14	70634091	70634091	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatacggtagaaggcacggCtcttctgttggtgggaaaga	10	9	16	6	2	2	2	0	0	2	2	2	4	2	4	0	6	1	4	0	6	4	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr14:70634091C>T	uc001xly.2	-	2	1803	c.1049G>A	c.(1048-1050)AGC>AAC	p.S350N	SLC8A3_uc001xlw.2_Missense_Mutation_p.S350N|SLC8A3_uc001xlx.2_Missense_Mutation_p.S350N|SLC8A3_uc001xlz.2_Missense_Mutation_p.S350N|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	350	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GAAGGCACGGCTCTTCTGTTG	0.493													17	66					0	0	0	0	T	70634091	T	T	70634091	3	4	206	1	0	0	0	0	1	0	0	0	14772	797	28	4	1873	4	SLC8A3	14	70634091	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	39494622	70634091	36715449	110	37685											
RIN3	79890	broad.mit.edu	37	chr14	93118236	93118236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggccccacgccgcccacCaccccctcccccagtgctgc	4	4	9	24	2	0	0	0	0	0	0	1	0	1	0	9	1	2	1	9	1	0	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr14:93118236C>T	uc001yap.2	+	6	994	c.842C>T	c.(841-843)CCA>CTA	p.P281L	RIN3_uc010auk.2_5'UTR|RIN3_uc001yaq.2_Missense_Mutation_p.P206L|RIN3_uc001yar.1_5'UTR|RIN3_uc001yas.1_5'UTR	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	281	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CGccgcccaccaccccctccc	0.308													25	23					0	0	0	0	T	93118236	T	T	93118236	3	4	206	1	0	0	0	0	1	0	0	0	13438	594	21	4	864	4	RIN3	14	93118236	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	22484145	93118236	14231304	111	37686											
MGA	23269	broad.mit.edu	37	chr15	42054540	42054540	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaacctttgattctttccaGaaaaaaagaccaggccacag	16	8	7	10	0	1	3	0	1	1	2	2	4	2	3	4	1	1	0	4	1	4	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr15:42054540G>C	uc010ucy.1	+	22	7905	c.7724G>C	c.(7723-7725)AGA>ACA	p.R2575T	MGA_uc010ucz.1_Missense_Mutation_p.R2366T|MGA_uc010uda.1_Missense_Mutation_p.R1191T	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2536						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		ATTCTTTCCAGAAAAAAAGAC	0.423													9	62					0	0	0	0	C	42054540	C	C	42054540	3	2	206	1	0	0	0	0	1	0	0	0	9593	942	33	2	7806	2	MGA	15	42054540	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08		42054540	60476852	112	37687											
SPTBN5	51332	broad.mit.edu	37	chr15	42166142	42166142	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctcctggcactgctccacGatgtgttgggcttgggggtg	4	11	16	10	1	0	0	0	0	0	0	2	1	2	0	2	4	2	5	2	4	0	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr15:42166142G>T	uc001zos.2	-	25	5019	c.4686C>A	c.(4684-4686)ATC>ATA	p.I1562I		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1597	Spectrin 12.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		ACTGCTCCACGATGTGTTGGG	0.647													22	24					3.62473e-10	1.02172e-09	1	0	T	42166142	T	T	42166142	2	4	206	1	0	0	0	0	0	0	0	1	15188	1048	37	3		3	SPTBN5	15	42166142	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08	111602	42166142	60365250	113	37688											
DMXL2	23312	broad.mit.edu	37	chr15	51773152	51773152	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttcttaattcagtcataaGgatctttaaacaagctctga	13	15	6	7	0	5	1	2	1	3	0	5	2	5	2	0	1	2	2	0	1	5	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr15:51773152G>T	uc002abf.2	-	24	6376	c.6151C>A	c.(6151-6153)CTT>ATT	p.L2051I	DMXL2_uc002abd.2_Missense_Mutation_p.L121I|DMXL2_uc010ufy.1_Missense_Mutation_p.L2051I|DMXL2_uc010bfa.2_Missense_Mutation_p.L1415I	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2051						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TCAGTCATAAGGATCTTTAAA	0.363													5	108					0.00116845	0.00299414	1	0	T	51773152	T	T	51773152	3	4	206	1	0	0	0	0	1	0	0	0	4617	1000	35	4	3042	4	DMXL2	15	51773152	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	9607010	51773152	50758240	114	37689											
TMOD2	29767	broad.mit.edu	37	chr15	52058689	52058689	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaatacaagaacattgatgaAgatgagcttcttggcaaact	17	10	8	6	0	1	5	0	3	1	2	1	5	1	5	0	1	4	2	0	1	6	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr15:52058689A>T	uc002abk.2	+	2	272	c.51A>T	c.(49-51)GAA>GAT	p.E17D	TMOD2_uc002abl.3_Missense_Mutation_p.E17D|TMOD2_uc010bfb.2_Translation_Start_Site	NM_014548	NP_055363	Q9NZR1	TMOD2_HUMAN	neuronal tropomodulin isoform a	17					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(2)	2				all cancers(107;0.00435)		ACATTGATGAAGATGAGCTTC	0.423													20	26					0	0	0	0	T	52058689	T	T	52058689	3	4	206	1	0	0	0	0	1	0	0	0	16300	69	3	5	53	5	TMOD2	15	52058689	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08	285537	52058689	50472703	115	37690											
MYO5A	4644	broad.mit.edu	37	chr15	52697571	52697571	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtattcggaaaattcccatTtgatgagattcactaattcc	13	14	6	8	1	1	2	1	2	0	1	4	4	3	3	2	1	0	1	2	1	4	7			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr15:52697571T>A	uc002aby.2	-	9	1210	c.966A>T	c.(964-966)CAA>CAT	p.Q322H	MYO5A_uc002abx.3_Missense_Mutation_p.Q322H|MYO5A_uc010uge.1_Missense_Mutation_p.Q191H	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	322	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		AAATTCCCATTTGATGAGATT	0.363													8	21					0	0	0	0	A	52697571	A	A	52697571	3	1	206	1	0	0	0	0	1	0	0	0	10131	1838	64	5	4733	5	MYO5A	15	52697571	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08	638882	52697571	49833821	116	37691											
HERC1	8925	broad.mit.edu	37	chr15	64067261	64067261	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaatgacatcgttgcaaaGactgagaccaggtcctgaca	14	8	10	9	1	0	5	0	4	0	2	2	6	1	5	2	1	1	2	2	1	2	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr15:64067261G>C	uc002amp.2	-	2	710	c.562C>G	c.(562-564)CTT>GTT	p.L188V	HERC1_uc010uil.1_Missense_Mutation_p.L188V|HERC1_uc010bgt.1_Missense_Mutation_p.L188V|HERC1_uc002amq.1_Missense_Mutation_p.L188V	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	188					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TCGTTGCAAAGACTGAGACCA	0.418													73	213					0	0	0	0	C	64067261	C	C	64067261	3	2	206	1	0	0	0	0	1	0	0	0	7096	942	33	2	14331	2	HERC1	15	64067261	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	11369690	64067261	38464131	117	37692											
CRABP1	1381	broad.mit.edu	37	chr15	78640277	78640277	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctctgcagacgtttggCgccgatgacgtggtctgcac	5	12	12	12	4	3	2	0	1	3	1	4	3	3	2	1	2	2	3	1	2	0	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr15:78640277C>T	uc002bdp.2	+	4	477	c.372C>T	c.(370-372)GGC>GGT	p.G124G		NM_004378	NP_004369	P29762	RABP1_HUMAN	cellular retinoic acid binding protein 1	124					multicellular organismal development|signal transduction	cytoplasm	retinal binding|retinol binding|transporter activity				0					Alitretinoin(DB00523)|Etretinate(DB00926)	AGACGTTTGGCGCCGATGACG	0.478													34	45					0	0	0	0	T	78640277	T	T	78640277	2	4	206	1	0	0	0	0	0	0	0	1	3858	755	27	1		1	CRABP1	15	78640277	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	14573016	78640277	23891115	118	37693											
C15orf42	90381	broad.mit.edu	37	chr15	90119305	90119305	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctggccccctgtccgcactCgcagagggagctgctgcagt	5	7	13	16	2	0	1	0	0	0	1	2	2	1	2	4	2	3	5	4	2	0	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr15:90119305C>T	uc002boe.2	+	1	488	c.488C>T	c.(487-489)TCG>TTG	p.S163L		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	163					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TGTCCGCACTCGCAGAGGGAG	0.682													9	8					0	0	0	0	T	90119305	T	T	90119305	3	4	206	1	0	0	0	0	1	0	0	0	1802	893	31	1	490	1	C15orf42	15	90119305	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	11479028	90119305	12412087	119	37694											
IQGAP1	8826	broad.mit.edu	37	chr15	90984777	90984777	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tattaatgaagctattgaccGtagaattccagccgacacat	14	11	7	9	2	0	3	0	2	0	1	1	4	1	3	3	0	2	2	3	0	6	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr15:90984777G>A	uc002bpl.1	+	8	790	c.689G>A	c.(688-690)CGT>CAT	p.R230H		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	230					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			GCTATTGACCGTAGAATTCCA	0.353													16	45					0	0	0	0	A	90984777	A	A	90984777	3	1	206	1	0	0	0	0	1	0	0	0	7853	1145	40	1	719	1	IQGAP1	15	90984777	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	865472	90984777	11546615	120	37695											
CREBBP	1387	broad.mit.edu	37	chr16	3778359	3778359	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccttgaggctgctggaacTggccgtgccccgccatgccc	4	8	13	16	2	0	1	0	1	0	0	1	2	1	2	6	3	4	2	6	3	1	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr16:3778359T>A	uc002cvv.2	-	31	6893	c.6689A>T	c.(6688-6690)CAG>CTG	p.Q2230L	CREBBP_uc002cvw.2_Missense_Mutation_p.Q2192L	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	2230					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CTGCTGGAACTGGCCGTGCCC	0.498			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				9	9					0	0	0	0	A	3778359	A	A	3778359	3	1	206	1	0	0	0	0	1	0	0	0	3876	1580	55	5	643	5	CREBBP	16	3778359	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08		3778359	86576394	121	37696											
ANKRD11	29123	broad.mit.edu	37	chr16	89351103	89351103	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtttggggacagcgcccTccgcgctggacaggaagggg	7	5	17	12	3	0	0	0	0	0	0	1	3	1	3	3	6	1	2	3	6	1	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr16:89351103T>G	uc002fmx.1	-	9	2308	c.1847A>C	c.(1846-1848)GAG>GCG	p.E616A	ANKRD11_uc002fmy.1_Missense_Mutation_p.E616A|ANKRD11_uc002fnc.1_Missense_Mutation_p.E616A|ANKRD11_uc002fnb.1_Missense_Mutation_p.E573A	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	616						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GACAGCGCCCTCCGCGCTGGA	0.537													10	41					0	0	0	0	G	89351103	G	G	89351103	3	3	206	1	0	0	0	0	1	0	0	0	639	1551	54	5	6164	5	ANKRD11	16	89351103	Missense_Mutation	SNP	T	TCGA-CV-6951-01A-11D-1912-08	85572744	89351103	1003650	122	37697											
TP53	7157	broad.mit.edu	37	chr17	7577129	7577129	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggcacaaacacgcacctcaAagctgttccgtcccagtaga	13	6	8	14	2	1	1	1	0	0	1	3	1	3	1	3	1	2	5	3	1	3	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:7577129A>C	uc002gim.2	-	8	1003	c.809T>G	c.(808-810)TTT>TGT	p.F270C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.F270C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.F138C|TP53_uc010cng.1_Missense_Mutation_p.F138C|TP53_uc002gii.1_Missense_Mutation_p.F138C|TP53_uc010cnh.1_Missense_Mutation_p.F270C|TP53_uc010cni.1_Missense_Mutation_p.F270C|TP53_uc002gij.2_Missense_Mutation_p.F270C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	270	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		F -> L (in sporadic cancers; somatic mutation).|F -> Y (in sporadic cancers; somatic mutation).|F -> C (in sporadic cancers; somatic mutation).|F -> V (in sporadic cancers; somatic mutation).|F -> S (in sporadic cancers; somatic mutation).|F -> I (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.F270L(22)|p.F270C(15)|p.F270V(8)|p.0?(7)|p.F270S(7)|p.F270Y(5)|p.F270I(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.G262_F270delGNLLGRNSF(2)|p.F270fs*72(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.S269fs*34(1)|p.F270_D281del12(1)|p.S269_F270insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACGCACCTCAAAGCTGTTCCG	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	15					0	0	0	0	C	7577129	C	C	7577129	3	2	206	1	0	0	0	0	1	0	0	0	16448	14	1	5	477	5	TP53	17	7577129	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08		7577129	73618081	123	37698											
TP53	7157	broad.mit.edu	37	chr17	7578217	7578217	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccacactatgtcgaaaaGtgtttctgtcatccaaatac	13	11	5	12	1	2	0	1	0	1	0	4	1	3	0	3	0	1	1	3	0	5	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:7578217G>A	uc002gim.2	-	6	826	c.632C>T	c.(631-633)ACT>ATT	p.T211I	TP53_uc002gig.1_Missense_Mutation_p.T211I|TP53_uc002gih.2_Missense_Mutation_p.T211I|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.T79I|TP53_uc010cng.1_Missense_Mutation_p.T79I|TP53_uc002gii.1_Missense_Mutation_p.T79I|TP53_uc010cnh.1_Missense_Mutation_p.T211I|TP53_uc010cni.1_Missense_Mutation_p.T211I|TP53_uc002gij.2_Missense_Mutation_p.T211I|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.T118I|TP53_uc002gio.2_Missense_Mutation_p.T79I|TP53_uc010vug.1_Missense_Mutation_p.T172I	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	211	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in sporadic cancers; somatic mutation).|T -> I (in sporadic cancers; somatic mutation).|T -> N (in sporadic cancers; somatic mutation).|T -> S (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T211T(9)|p.T211I(7)|p.0?(7)|p.T211N(4)|p.T211fs*4(3)|p.R209fs*35(2)|p.T211A(2)|p.T211fs*36(2)|p.T211fs*5(2)|p.D208fs*1(1)|p.T211_F212insX(1)|p.R209_R213delRNTFR(1)|p.D207_R213delDDRNTFR(1)|p.T211fs*28(1)|p.T211_S215delTFRHS(1)|p.K164_P219del(1)|p.D207_V216del10(1)|p.T211P(1)|p.T211S(1)|p.R209fs*6(1)|p.D208_V216delDRNTFRHSV(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGTCGAAAAGTGTTTCTGTC	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	22					0	0	0	0	A	7578217	A	A	7578217	3	1	206	1	0	0	0	0	1	0	0	0	16448	1029	36	4	662	4	TP53	17	7578217	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	1088	7578217	73616993	124	37699											
C17orf68	80169	broad.mit.edu	37	chr17	8131878	8131878	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaagaaagcacaataggacGgaggacagaggggctagtac	18	3	14	6	1	0	2	0	0	0	2	0	5	0	5	0	5	2	3	0	5	7	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:8131878G>A	uc002gkq.3	-	22	3516	c.3457C>T	c.(3457-3459)CGT>TGT	p.R1153C	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	1153					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						ACAATAGGACGGAGGACAGAG	0.507													57	234					0	0	0	0	A	8131878	A	A	8131878	3	1	206	1	0	0	0	0	1	0	0	0	1883	1116	39	1	204	1	C17orf68	17	8131878	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	553661	8131878	73063332	125	37700											
TTC19	54902	broad.mit.edu	37	chr17	15902870	15902870	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgccgccgccatctcgctCaggagctcctccacaaccgc	7	5	8	21	5	2	0	1	0	1	0	5	1	4	1	7	1	2	2	7	1	1	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:15902870C>G	uc002gph.1	+	1	89	c.71C>G	c.(70-72)TCA>TGA	p.S24*	ZSWIM7_uc002gpe.2_Silent_p.L13L|ZSWIM7_uc002gpf.2_Silent_p.L13L|ZSWIM7_uc002gpg.2_RNA|TTC19_uc010cox.1_RNA	NM_017775	NP_060245	Q6DKK2	TTC19_HUMAN	tetratricopeptide repeat domain 19	Error:Variant_position_missing_in_Q6DKK2_after_alignment					cell cycle|cytokinesis|mitochondrial respiratory chain complex III assembly	centrosome|midbody|mitochondrial inner membrane	protein binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CCATCTCGCTCAGGAGCTCCT	0.746													3	12					0	0	0	0	G	15902870	G	G	15902870	4	3	206	1	0	0	0	0	0	1	0	0	16754	838	29	2	73	2	TTC19	17	15902870	Nonsense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	7770992	15902870	65292340	126	37701											
TOP3A	7156	broad.mit.edu	37	chr17	18178288	18178288	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtccaggacggggctccaGaagtccctgtcgggagagtc	7	7	15	12	2	0	2	0	0	0	2	5	4	3	3	3	4	0	1	3	4	1	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:18178288G>T	uc002gsx.1	-	19	3063	c.2834C>A	c.(2833-2835)TCT>TAT	p.S945Y	TOP3A_uc010cpz.1_Missense_Mutation_p.S397Y|TOP3A_uc010vxr.1_Missense_Mutation_p.S475Y|TOP3A_uc002gsw.1_Missense_Mutation_p.S397Y|TOP3A_uc010vxs.1_Missense_Mutation_p.S843Y	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	945					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						CGGGGCTCCAGAAGTCCCTGT	0.502													26	56					4.7796e-09	1.33062e-08	1	0	T	18178288	T	T	18178288	3	4	206	1	0	0	0	0	1	0	0	0	16434	942	33	2	175	2	TOP3A	17	18178288	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	2275418	18178288	63016922	127	37702											
CACNB1	782	broad.mit.edu	37	chr17	37343809	37343809	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cacctcatcccctggagacgGattgtagccaacatttgtcc	9	10	8	14	1	1	1	1	0	0	1	3	3	3	2	5	2	2	1	5	2	2	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:37343809G>T	uc002hrm.1	-	4	490	c.337C>A	c.(337-339)CCG>ACG	p.P113T	CACNB1_uc002hrl.1_5'UTR|CACNB1_uc002hrn.2_Missense_Mutation_p.P113T|CACNB1_uc002hro.2_Missense_Mutation_p.P113T|CACNB1_uc002hrp.1_Missense_Mutation_p.P113T|CACNB1_uc010web.1_Missense_Mutation_p.P66T	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	113	SH3.				axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	CCTGGAGACGGATTGTAGCCA	0.532													53	71					2.17126e-26	6.44235e-26	1	0	T	37343809	T	T	37343809	3	4	206	1	0	0	0	0	1	0	0	0	2564	1174	41	2	1767	2	CACNB1	17	37343809	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	19165521	37343809	43851401	128	37703											
CDK12	51755	broad.mit.edu	37	chr17	37657685	37657685	+	Frame_Shift_Del	DEL	A	-	-																															agtgttctaacattttgctgAataacaggtaacatagtaac																										TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:37657685delA	uc010cvv.2	+	6	3188	c.2602delA	c.(2602-2604)AATfs	p.N868fs	CDK12_uc010wef.1_Frame_Shift_Del_p.N867fs|CDK12_uc002hrw.3_Frame_Shift_Del_p.N868fs	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	868	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						CATTTTGCTGAATAACAGGTA	0.333										TCGA Ovarian(9;0.13)			---	---	---								-	37657685	-	-	37657685	7	5	206	1	0	1	0	1	0	0	0	0	3143	246	9	0	2624	0	CDK12	17	37657685	Frame_Shift_Del	DEL	A	TCGA-CV-6951-01A-11D-1912-08	313876	37657685	43537525	129	37704											
KRT27	342574	broad.mit.edu	37	chr17	38933792	38933792	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctccatctatcaggaggcAgtaggtctcaatttcttttt	8	17	7	9	0	5	0	2	0	4	0	7	1	5	1	1	3	0	2	1	3	3	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:38933792A>T	uc002hvg.2	-	6	1206	c.1165T>A	c.(1165-1167)TGC>AGC	p.C389S		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	389	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				ATCAGGAGGCAGTAGGTCTCA	0.443													23	105					0	0	0	0	T	38933792	T	T	38933792	3	4	206	1	0	0	0	0	1	0	0	0	8503	188	7	5	226	5	KRT27	17	38933792	Missense_Mutation	SNP	A	TCGA-CV-6951-01A-11D-1912-08	1276107	38933792	42261418	130	37705											
TUBD1	51174	broad.mit.edu	37	chr17	57951959	57951959	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgcttgaggaggccagccCaagtaaatgtggtgtatgcc	11	9	13	8	0	0	1	0	1	0	0	0	2	0	2	3	3	3	3	3	3	5	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:57951959C>A	uc002ixw.1	-	6	1153	c.875G>T	c.(874-876)TGG>TTG	p.W292L	TUBD1_uc010ddf.1_Intron|TUBD1_uc010ddg.1_Missense_Mutation_p.W257L|TUBD1_uc010ddh.1_Intron|TUBD1_uc010wok.1_Missense_Mutation_p.W292L|TUBD1_uc002ixx.1_Intron|TUBD1_uc010wol.1_Missense_Mutation_p.W76L|TUBD1_uc010ddi.1_Intron	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	292					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			GAGGCCAGCCCAAGTAAATGT	0.418													7	244					0.00198382	0.00502642	1	0	A	57951959	A	A	57951959	3	1	206	1	0	0	0	0	1	0	0	0	16830	595	21	4	502	4	TUBD1	17	57951959	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	19018167	57951959	23243251	131	37706											
ITGB4	3691	broad.mit.edu	37	chr17	73749930	73749930	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcccccggagctcatccCgcgcctgtcggccagcagcg	4	5	13	19	5	1	0	1	0	0	0	3	1	2	1	5	2	4	3	5	2	0	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:73749930C>T	uc002jpg.2	+	33	4380	c.4193C>T	c.(4192-4194)CCG>CTG	p.P1398L	ITGB4_uc002jph.2_Intron|ITGB4_uc002jpi.3_Intron|ITGB4_uc002jpj.2_Intron|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1398	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GAGCTCATCCCGCGCCTGTCG	0.776													7	7					0	0	0	0	T	73749930	T	T	73749930	3	4	206	1	0	0	0	0	1	0	0	0	7936	652	23	1	4319	1	ITGB4	17	73749930	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	15797971	73749930	7445280	132	37707											
ENGASE	64772	broad.mit.edu	37	chr17	77073809	77073809	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtcttcgctggaggagctCttggcgtggaagccccgctt	4	12	14	11	3	2	0	0	0	2	0	3	3	2	3	2	4	2	3	2	4	1	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr17:77073809C>G	uc002jwv.2	+	3	287	c.279C>G	c.(277-279)CTC>CTG	p.L93L	ENGASE_uc002jwu.1_Silent_p.L93L|ENGASE_uc010wtz.1_5'UTR|ENGASE_uc002jww.2_5'Flank	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	93						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						TGGAGGAGCTCTTGGCGTGGA	0.547													56	65					0	0	0	0	G	77073809	G	G	77073809	2	3	206	1	0	0	0	0	0	0	0	1	5142	900	32	2		2	ENGASE	17	77073809	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	3323879	77073809	4121401	133	37708											
C18orf8	29919	broad.mit.edu	37	chr18	21111620	21111620	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaacatgttgcttttttCaaacagatttttggagacca	13	14	8	6	0	1	3	1	0	0	3	1	5	1	3	1	1	3	2	1	1	3	6			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr18:21111620C>G	uc010xax.1	+	21	2047	c.1926C>G	c.(1924-1926)TTC>TTG	p.F642L	C18orf8_uc002kul.2_RNA|C18orf8_uc010xay.1_Nonsense_Mutation_p.S225*|NPC1_uc010dlu.1_Intron|NPC1_uc010xaz.1_3'UTR|NPC1_uc002kum.3_3'UTR	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	642										ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TTGCTTTTTTCAAACAGATTT	0.348													24	76					0	0	0	0	G	21111620	G	G	21111620	3	3	206	1	0	0	0	0	1	0	0	0	1916	825	29	2	2004	2	C18orf8	18	21111620	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08		21111620	56965628	134	37709											
HAUS1	115106	broad.mit.edu	37	chr18	43698200	43698200	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaatttttcccccgccaatCtctctagcactggttccagg	7	13	7	14	1	2	1	0	1	2	0	5	1	4	1	4	2	1	2	4	2	3	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr18:43698200C>A	uc002lbu.2	+	3	339	c.259C>A	c.(259-261)CTC>ATC	p.L87I	HAUS1_uc002lbv.2_Missense_Mutation_p.L11I	NM_138443	NP_612452	Q96CS2	HAUS1_HUMAN	coiled-coil domain containing 5	87					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				ovary(1)	1						CCCCGCCAATCTCTCTAGCAC	0.418													17	77					8.34094e-07	2.25255e-06	1	0	A	43698200	A	A	43698200	3	1	206	1	0	0	0	0	1	0	0	0	7004	913	32	2	269	2	HAUS1	18	43698200	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	22586580	43698200	34379048	135	37710											
CDH7	1005	broad.mit.edu	37	chr18	63547973	63547973	+	Frame_Shift_Del	DEL	C	-	-																															tgactccctgcagacatatgCttttgaaggaaatggctcag																										TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr18:63547973delC	uc002ljz.2	+	12	2526	c.2201delC	c.(2200-2202)GCTfs	p.A734fs	CDH7_uc002lkb.2_Frame_Shift_Del_p.A734fs	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	734	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CAGACATATGCTTTTGAAGGA	0.423													---	---	---								-	63547973	-	-	63547973	7	5	206	1	0	1	0	1	0	0	0	0	3130	797	28	0	2243	0	CDH7	18	63547973	Frame_Shift_Del	DEL	C	TCGA-CV-6951-01A-11D-1912-08	19849773	63547973	14529275	136	37711											
AP3D1	8943	broad.mit.edu	37	chr19	2110868	2110868	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cacagtgacctggctgtcctCctgcagactgccccggatgt	6	9	11	15	1	0	2	0	1	0	1	2	3	2	3	5	2	2	2	5	2	0	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr19:2110868C>G	uc002luz.2	-	25	3050	c.2827G>C	c.(2827-2829)GAG>CAG	p.E943Q	AP3D1_uc010dsv.2_Missense_Mutation_p.E33Q|AP3D1_uc002luy.2_Missense_Mutation_p.E902Q|AP3D1_uc002lva.2_Missense_Mutation_p.E1005Q	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	943					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCTGTCCTCCTGCAGACTG	0.622													5	29					0	0	0	0	G	2110868	G	G	2110868	3	3	206	1	0	0	0	0	1	0	0	0	746	864	30	2	658	2	AP3D1	19	2110868	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08		2110868	57018115	137	37712											
CALR	811	broad.mit.edu	37	chr19	13054605	13054607	+	In_Frame_Del	DEL	GAG	-	-																															aagaagacaagaaacgcaaaGaggaggaggaggcagaggac																										TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	cf5ad788-c4aa-4ec9-979e-303ad1c5f643	g.chr19:13054605_13054607delGAG	uc002mvu.2	+	9	1212_1214	c.1132_1134delGAG	c.(1132-1134)GAGdel	p.E381del	CALR_uc002mvv.2_RNA|RAD23A_uc002mvw.1_5'Flank|RAD23A_uc002mvx.1_5'Flank|RAD23A_uc002mvz.1_5'Flank|RAD23A_uc002mwa.1_5'Flank|RAD23A_uc002mvy.1_5'Flank|RAD23A_uc010xmw.1_5'Flank	NM_004343	NP_004334	P27797	CALR_HUMAN	calreticulin precursor	381	C-domain.|Asp/Glu/Lys-rich.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAAACGCAAAgaggaggaggagg	0.291													---	---	---								-	13054607	-	-	13054605	7	5	206	1	0	1	0	1	0	0	0	0	2604	943	33	0	1166	0	CALR	19	13054605	In_Frame_Del	DEL	GAG	TCGA-CV-6951-01A-11D-1912-08	10943737	13054605	46074378	138	37713											
DDX39	10212	broad.mit.edu	37	chr19	14520565	14520565	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aagtatcacctggttaaactCcagcacatccaagagatcaa	16	8	6	11	0	2	1	2	0	0	1	4	2	4	1	3	1	2	3	3	1	6	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr19:14520565C>G	uc010xnp.1	-	7	898	c.853G>C	c.(853-855)GAG>CAG	p.E285Q	DDX39_uc002myo.2_Missense_Mutation_p.E285Q|DDX39_uc010dzl.2_RNA	NM_005804	NP_005795	O00148	DX39A_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39	285	Helicase C-terminal.				mRNA export from nucleus|nuclear mRNA splicing, via spliceosome	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding				0						TGGTTAAACTCCAGCACATCC	0.562													19	41					0	0	0	0	G	14520565	G	G	14520565	3	3	206	1	0	0	0	0	1	0	0	0	4374	864	30	2	450	2	DDX39	19	14520565	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	1465960	14520565	44608418	139	37714											
HSH2D	84941	broad.mit.edu	37	chr19	16268177	16268177	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggagcctcaaaatgctccCcgagagaggccagagggtcc	11	4	14	12	1	1	2	1	0	0	2	3	6	3	3	5	3	2	1	5	3	2	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr19:16268177C>T	uc002ndp.3	+	8	1163	c.632C>T	c.(631-633)CCC>CTC	p.P211L	HSH2D_uc002ndr.2_Missense_Mutation_p.P154L|HSH2D_uc010ead.2_RNA	NM_032855	NP_116244	Q96JZ2	HSH2D_HUMAN	hematopoietic SH2 domain containing	211						cytoplasm|nucleus					0						AAAATGCTCCCCGAGAGAGGC	0.562													19	34					0	0	0	0	T	16268177	T	T	16268177	3	4	206	1	0	0	0	0	1	0	0	0	7439	623	22	4	650	4	HSH2D	19	16268177	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	1747612	16268177	42860806	140	37715											
RYR1	6261	broad.mit.edu	37	chr19	38943488	38943488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcttcagcgggaagccacGgggctcggggccacccgctg	6	4	16	15	4	1	0	1	0	0	0	2	1	1	1	3	5	3	3	3	5	1	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr19:38943488G>A	uc002oit.2	+	13	1404	c.1274G>A	c.(1273-1275)CGG>CAG	p.R425Q	RYR1_uc002oiu.2_Missense_Mutation_p.R425Q	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	425	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGGAAGCCACGGGGCTCGGGG	0.662													5	15					0	0	0	0	A	38943488	A	A	38943488	3	1	206	1	0	0	0	0	1	0	0	0	13833	1116	39	1	1324	1	RYR1	19	38943488	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	22675311	38943488	20185495	141	37716											
GRIN2D	2906	broad.mit.edu	37	chr19	48917263	48917263	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaggtacttcatgaacatCacgtgggataaccgggatta	12	9	12	8	2	2	1	2	1	0	0	2	3	2	3	1	4	3	2	1	4	4	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr19:48917263C>T	uc002pjc.3	+	4	1189	c.1101C>T	c.(1099-1101)ATC>ATT	p.I367I		NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	367	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	TCATGAACATCACGTGGGATA	0.587													8	47					0	0	0	0	T	48917263	T	T	48917263	2	4	206	1	0	0	0	0	0	0	0	1	6821	816	29	2		2	GRIN2D	19	48917263	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	9973775	48917263	10211720	142	37717											
ZNF347	84671	broad.mit.edu	37	chr19	53644215	53644215	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattatacttgtaaggtttCtctccagtatgaattcgctg	9	17	7	8	1	2	1	1	1	1	0	5	1	3	1	1	1	1	4	1	1	5	7			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr19:53644215C>A	uc002qbb.1	-	5	1935	c.1866G>T	c.(1864-1866)GAG>GAT	p.E622D	ZNF347_uc010eql.1_Missense_Mutation_p.E623D|ZNF347_uc002qbc.1_Missense_Mutation_p.E623D	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	622					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TGTAAGGTTTCTCTCCAGTAT	0.368													40	43					2.19962e-31	6.61353e-31	1	0	A	53644215	A	A	53644215	3	1	206	1	0	0	0	0	1	0	0	0	17928	912	32	2	657	2	ZNF347	19	53644215	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	4726952	53644215	5484768	143	37718											
ZNF524	147807	broad.mit.edu	37	chr19	56114117	56114117	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttacagaggccaacacgctCcggcgccatgcgaagcgcaa	11	5	11	14	5	0	1	0	0	0	1	1	2	1	1	3	2	4	2	3	2	4	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr19:56114117C>T	uc002qlk.1	+	2	722	c.639C>T	c.(637-639)CTC>CTT	p.L213L	FIZ1_uc002qlj.3_5'Flank	NM_153219	NP_694951	Q96C55	ZN524_HUMAN	zinc finger protein 524	213	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CCAACACGCTCCGGCGCCATG	0.711													18	9					0	0	0	0	T	56114117	T	T	56114117	2	4	206	1	0	0	0	0	0	0	0	1	18033	842	30	2		2	ZNF524	19	56114117	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	2469902	56114117	3014866	144	37719											
ZNF530	348327	broad.mit.edu	37	chr19	58118331	58118331	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttgcaaaactgacctcattCgacaccagacagttcacact	13	9	6	13	1	2	2	2	1	0	1	3	3	2	2	2	0	2	3	2	0	2	3			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr19:58118331C>T	uc002qpk.2	+	3	1658	c.1438C>T	c.(1438-1440)CGA>TGA	p.R480*	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	480	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGACCTCATTCGACACCAGAC	0.433													29	28					0	0	0	0	T	58118331	T	T	58118331	4	4	206	1	0	0	0	0	0	1	0	0	18038	876	31	1	1448	1	ZNF530	19	58118331	Nonsense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08	2004214	58118331	1010652	145	37720											
HSPA12B	116835	broad.mit.edu	37	chr20	3726199	3726199	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagacgatgcccgccctggaGgtgttcgcccatgccctgcg	6	7	13	15	4	0	1	0	0	0	1	1	3	0	2	4	2	3	1	4	2	1	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr20:3726199G>A	uc002wjd.2	+	6	616	c.513G>A	c.(511-513)GAG>GAA	p.E171E	HSPA12B_uc010zqi.1_Silent_p.E171E|HSPA12B_uc002wje.2_Silent_p.E84E|HSPA12B_uc010zqj.1_Silent_p.E5E	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	171							ATP binding				0						CCGCCCTGGAGGTGTTCGCCC	0.637													12	51					0	0	0	0	A	3726199	A	A	3726199	2	1	206	1	0	0	0	0	0	0	0	1	7444	991	35	4		4	HSPA12B	20	3726199	Silent	SNP	G	TCGA-CV-6951-01A-11D-1912-08		3726199	59299321	146	37721											
CBFA2T2	9139	broad.mit.edu	37	chr20	32217677	32217677	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaacggggaccgagttggtCtccaggcagcacagccctgg	10	5	14	12	2	1	0	0	0	1	0	2	2	1	1	3	5	3	3	3	5	2	1			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr20:32217677C>T	uc002wzg.1	+	9	1749	c.1212C>T	c.(1210-1212)GTC>GTT	p.V404V	CBFA2T2_uc010zug.1_Silent_p.V178V|CBFA2T2_uc002wze.1_Silent_p.V395V|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Silent_p.V375V|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	404						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						CCGAGTTGGTCTCCAGGCAGC	0.507													22	27					0	0	0	0	T	32217677	T	T	32217677	2	4	206	1	0	0	0	0	0	0	0	1	2709	900	32	2		2	CBFA2T2	20	32217677	Silent	SNP	C	TCGA-CV-6951-01A-11D-1912-08	28491478	32217677	30807843	147	37722											
PTPRT	11122	broad.mit.edu	37	chr20	40757407	40757407	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cactcacgtcaatgtagttgGcattgatgtagtcagagtgc	10	12	11	8	1	3	2	3	1	0	1	3	2	3	2	0	1	1	4	0	1	3	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr20:40757407G>A	uc002xkg.2	-	19	3018	c.2834C>T	c.(2833-2835)GCC>GTC	p.A945V	PTPRT_uc010ggj.2_Missense_Mutation_p.A964V|PTPRT_uc010ggi.2_Missense_Mutation_p.A148V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	945	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AATGTAGTTGGCATTGATGTA	0.542													6	64					0	0	0	0	A	40757407	A	A	40757407	3	1	206	1	0	0	0	0	1	0	0	0	12877	1203	42	4	1543	4	PTPRT	20	40757407	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	8539730	40757407	22268113	148	37723											
MYH9	4627	broad.mit.edu	37	chr22	36712573	36712573	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaggctcacatcaaagatctCgaagccggcaatgtccagga	14	6	10	11	2	3	1	2	0	1	1	5	3	4	2	2	3	1	2	2	3	4	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chr22:36712573C>T	uc003apg.2	-	12	1600	c.1369G>A	c.(1369-1371)GAG>AAG	p.E457K	MYH9_uc003aph.1_Missense_Mutation_p.E321K	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	457	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TCAAAGATCTCGAAGCCGGCA	0.572			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				34	86					0	0	0	0	T	36712573	T	T	36712573	3	4	206	1	0	0	0	0	1	0	0	0	10095	893	31	1	4633	1	MYH9	22	36712573	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08		36712573	14591993	149	37724											
SLC35A2	7355	broad.mit.edu	37	chrX	48762651	48762651	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcctggacaatggcgaCgccagtgaagaggagcagca	11	5	15	10	2	0	2	0	1	0	1	0	5	0	4	2	3	3	2	2	3	2	0			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chrX:48762651C>T	uc004dlo.1	-	4	539	c.535G>A	c.(535-537)GTC>ATC	p.V179I	SLC35A2_uc011mml.1_Missense_Mutation_p.V192I|SLC35A2_uc004dlp.1_Missense_Mutation_p.V179I|SLC35A2_uc011mmm.1_Missense_Mutation_p.V207I|SLC35A2_uc011mmn.1_Missense_Mutation_p.V118I|SLC35A2_uc004dlr.1_Intron|SLC35A2_uc004dlq.2_Intron	NM_005660	NP_005651	P78381	S35A2_HUMAN	solute carrier family 35, member A2 isoform a	179	Helical; (Potential).				galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)	1						ACAATGGCGACGCCAGTGAAG	0.657													7	4					0	0	0	0	T	48762651	T	T	48762651	3	4	206	1	0	0	0	0	1	0	0	0	14635	536	19	1	819	1	SLC35A2	23	48762651	Missense_Mutation	SNP	C	TCGA-CV-6951-01A-11D-1912-08		48762651	106507909	150	37725											
TAF1	6872	broad.mit.edu	37	chrX	70618519	70618519	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcggcttaagaggaaccagGaaaaggagaagcttaagggt	15	5	16	5	1	0	2	0	0	0	2	0	5	0	4	1	6	2	2	1	6	6	2			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chrX:70618519G>C	uc004dzu.3	+	24	3766	c.3715G>C	c.(3715-3717)GAA>CAA	p.E1239Q	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.E1260Q|TAF1_uc004dzv.3_Missense_Mutation_p.E413Q	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1239	HMG box.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				GAGGAACCAGGAAAAGGAGAA	0.458													19	2					0	0	0	0	C	70618519	C	C	70618519	3	2	206	1	0	0	0	0	1	0	0	0	15579	1175	41	2	3872	2	TAF1	23	70618519	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	21855868	70618519	84652041	151	37726											
MAGEC3	139081	broad.mit.edu	37	chrX	140985505	140985505	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccatcctggtacatggatGctttgaaagatatggaagac	12	12	10	7	0	0	3	0	1	0	2	2	5	2	5	2	3	2	2	2	3	4	4			TCGA-CV-6951-01A-11D-1912-08	TCGA-CV-6951-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e1bf26c-6a68-44d2-aaa8-9af2f67828aa	de932da1-dde5-452c-bd57-3558533b8206	g.chrX:140985505G>T	uc011mwp.1	+	8	1819	c.1819G>T	c.(1819-1821)GCT>TCT	p.A607S	MAGEC3_uc004fbs.2_3'UTR|MAGEC3_uc010nsj.2_3'UTR	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	607	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GTACATGGATGCTTTGAAAGA	0.488													46	15					8.01111e-26	2.36144e-25	1	0	T	140985505	T	T	140985505	3	4	206	1	0	0	0	0	1	0	0	0	9235	1319	46	4	2216	4	MAGEC3	23	140985505	Missense_Mutation	SNP	G	TCGA-CV-6951-01A-11D-1912-08	70366986	140985505	14285055	152	37727											
RNF220	55182	broad.mit.edu	37	chr1	44878151	44878151	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggccctttgcctccaccgagGaccgggagagctatcagtca	8	7	12	14	2	2	1	2	0	0	1	3	4	3	2	5	3	2	1	5	3	1	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:44878151G>A	uc001clv.1	+	2	742	c.382G>A	c.(382-384)GAC>AAC	p.D128N	RNF220_uc001clw.1_Missense_Mutation_p.D128N	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	128					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CTCCACCGAGGACCGGGAGAG	0.552													25	95					0	0	0	0	A	44878151	A	A	44878151	3	1	207	1	0	0	0	0	1	0	0	0	13548	1174	41	2	384	2	RNF220	1	44878151	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08		44878151	204372470	1	37728											
C1orf163	65260	broad.mit.edu	37	chr1	53158471	53158471	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctcttcacagttaaactTcaacaccttggcagcctcat	10	13	5	13	0	4	0	3	0	1	0	5	0	4	0	2	1	3	3	2	1	3	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:53158471T>C	uc001cui.1	-	2	215	c.175A>G	c.(175-177)AAG>GAG	p.K59E		NM_023077	NP_075565	Q96BR5	SELR1_HUMAN	hypothetical protein LOC65260	59	Sel1-like 1.						binding				0						CAGTTAAACTTCAACACCTTG	0.498													22	67					0	0	0	0	C	53158471	C	C	53158471	3	2	207	1	0	0	0	0	1	0	0	0	2020	1792	62	5	528	5	C1orf163	1	53158471	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	8280320	53158471	196092150	2	37729											
HOOK1	51361	broad.mit.edu	37	chr1	60309235	60309235	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaaagtattttcatgcacaAttacaactagaacaattaca	20	11	3	7	0	1	1	1	0	0	1	1	1	1	1	0	0	5	2	0	0	10	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:60309235A>G	uc009wad.2	+	10	855	c.753A>G	c.(751-753)CAA>CAG	p.Q251Q	HOOK1_uc001czo.2_Silent_p.Q251Q|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Silent_p.Q209Q	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	251	Potential.|Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					TTCATGCACAATTACAACTAG	0.333													14	31					0	0	0	0	G	60309235	G	G	60309235	2	3	207	1	0	0	0	0	0	0	0	1	7321	98	4	5		5	HOOK1	1	60309235	Silent	SNP	A	TCGA-CV-6952-01A-11D-1912-08	7150764	60309235	188941386	3	37730											
WDR63	126820	broad.mit.edu	37	chr1	85547058	85547058	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaggacctgcgcaacagagCtgcagtatctgatttccacc	10	9	10	12	1	1	3	0	2	1	1	2	4	2	4	3	1	4	4	3	1	2	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:85547058C>A	uc001dkt.2	+	4	436	c.245C>A	c.(244-246)GCT>GAT	p.A82D	WDR63_uc009wcl.2_Missense_Mutation_p.A82D	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	82								p.A82D(1)		upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		CGCAACAGAGCTGCAGTATCT	0.368													13	50					0.000308642	0.000329403	1	0	A	85547058	A	A	85547058	3	1	207	1	0	0	0	0	1	0	0	0	17382	797	28	4	255	4	WDR63	1	85547058	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	25237823	85547058	163703563	4	37731											
SASS6	163786	broad.mit.edu	37	chr1	100591488	100591488	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagttcaatgctcattcttaTacttactctcctgtaggaaa	11	16	5	9	0	4	0	2	0	2	0	5	1	4	1	1	1	3	3	1	1	7	7			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:100591488T>C	uc001dsu.2	-	2	217	c.76A>G	c.(76-78)ATA>GTA	p.I26V	SASS6_uc009wdz.2_5'UTR	NM_194292	NP_919268	Q6UVJ0	SAS6_HUMAN	spindle assembly abnormal protein 6	26					centriole replication	centriole		p.I26V(1)		upper_aerodigestive_tract(1)|ovary(1)	2		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		CTCATTCTTATACTTACTCTC	0.333													22	58					0	0	0	0	C	100591488	C	C	100591488	3	2	207	1	0	0	0	0	1	0	0	0	13915	1406	49	5	1961	5	SASS6	1	100591488	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	15044430	100591488	148659133	5	37732											
VAV3	10451	broad.mit.edu	37	chr1	108116684	108116684	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttaccctgccatttacttcTcctctccaccagccatttgc	6	14	3	18	0	2	0	0	0	2	0	4	0	2	0	6	0	5	0	6	0	2	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:108116684T>A	uc001dvk.1	-	26	2541	c.2487A>T	c.(2485-2487)GGA>GGT	p.G829G	VAV3_uc010ouu.1_Silent_p.G261G|VAV3_uc001dvj.1_Silent_p.G269G|VAV3_uc010ouv.1_Silent_p.G233G|VAV3_uc010ouw.1_Silent_p.G857G	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	829	SH3 2.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CATTTACTTCTCCTCTCCACC	0.483													47	209					0	0	0	0	A	108116684	A	A	108116684	2	1	207	1	0	0	0	0	0	0	0	1	17201	1538	54	5		5	VAV3	1	108116684	Silent	SNP	T	TCGA-CV-6952-01A-11D-1912-08	7525196	108116684	141133937	6	37733											
LRIG2	9860	broad.mit.edu	37	chr1	113657294	113657294	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctaacacccttgggacagaaCgtggccacatttacctaaat	13	9	7	12	1	0	1	0	0	0	1	0	2	0	2	3	2	3	0	3	2	5	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:113657294C>T	uc001edf.1	+	15	2524	c.2326C>T	c.(2326-2328)CGT>TGT	p.R776C	LRIG2_uc009wgn.1_Missense_Mutation_p.R673C	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	776	Ig-like C2-type 3.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TGGGACAGAACGTGGCCACAT	0.463													25	104					0	0	0	0	T	113657294	T	T	113657294	3	4	207	1	0	0	0	0	1	0	0	0	8995	536	19	1	2384	1	LRIG2	1	113657294	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	5540610	113657294	135593327	7	37734											
HIPK1	204851	broad.mit.edu	37	chr1	114499830	114499830	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtcagatcaagagtcccttCactacacatgttgccccaaa	13	9	6	13	0	3	2	3	0	0	2	4	2	4	2	3	0	2	1	3	0	3	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:114499830C>T	uc001eem.2	+	7	1838	c.1677C>T	c.(1675-1677)TTC>TTT	p.F559F	HIPK1_uc001eel.2_Silent_p.F559F|HIPK1_uc001een.2_Silent_p.F559F|HIPK1_uc001eeo.2_Silent_p.F185F|HIPK1_uc001eep.2_Silent_p.F165F	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGAGTCCCTTCACTACACATG	0.393													12	43					0	0	0	0	T	114499830	T	T	114499830	2	4	207	1	0	0	0	0	0	0	0	1	7155	825	29	2		2	HIPK1	1	114499830	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	842536	114499830	134750791	8	37735											
IGSF3	3321	broad.mit.edu	37	chr1	117158883	117158883	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgctgggtgtagatggcataGgggaaggaagagtccatggt	10	8	18	5	1	0	2	0	0	0	2	1	4	1	4	1	6	0	3	1	6	4	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:117158883G>A	uc001egr.1	-	3	945	c.240C>T	c.(238-240)CCC>CCT	p.P80P	IGSF3_uc001egq.1_Silent_p.P80P	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	80	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		AGATGGCATAGGGGAAGGAAG	0.557													6	41					0	0	0	0	A	117158883	A	A	117158883	2	1	207	1	0	0	0	0	0	0	0	1	7640	987	35	4		4	IGSF3	1	117158883	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	2659053	117158883	132091738	9	37736											
CHD1L	9557	broad.mit.edu	37	chr1	146739091	146739091	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttttaaatttcagatgcatTtgaaaatgagacggcaaaga	16	13	8	4	1	1	4	1	2	0	3	1	5	1	4	0	1	1	2	0	1	5	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:146739091T>G	uc001epm.3	+	9	965	c.902T>G	c.(901-903)TTT>TGT	p.F301C	uc001epp.2_Intron|CHD1L_uc001epn.3_Missense_Mutation_p.F188C|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Missense_Mutation_p.F301C|CHD1L_uc010ozp.1_Missense_Mutation_p.F20C|CHD1L_uc001epo.3_Missense_Mutation_p.F97C|CHD1L_uc010ozq.1_Translation_Start_Site|CHD1L_uc009wji.2_Missense_Mutation_p.F20C	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	301					chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding	p.F301C(1)		ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					TCAGATGCATTTGAAAATGAG	0.353													9	28					0	0	0	0	G	146739091	G	G	146739091	3	3	207	1	0	0	0	0	1	0	0	0	3339	1841	64	5	936	5	CHD1L	1	146739091	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	29580208	146739091	102511530	10	37737											
HRNR	388697	broad.mit.edu	37	chr1	152188024	152188024	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctccatgttggccacagctCgatgactgtcctgatgcaga	8	10	11	12	1	0	3	0	2	0	1	3	4	2	3	3	1	2	4	3	1	0	1	rs142170860		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:152188024C>T	uc001ezt.1	-	3	6157	c.6081G>A	c.(6079-6081)TCG>TCA	p.S2027S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2027	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCACAGCTCGATGACTGTC	0.562													85	672					0	0	0	0	T	152188024	T	T	152188024	2	4	207	1	0	0	0	0	0	0	0	1	7398	871	31	1		1	HRNR	1	152188024	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	5448933	152188024	97062597	11	37738											
APCS	325	broad.mit.edu	37	chr1	159558171	159558171	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctccagtgcacatctgtgtGagctgggagtcctcatcagg	7	10	13	11	0	3	1	2	1	1	0	5	2	5	2	2	2	2	3	2	2	0	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:159558171G>C	uc001ftv.2	+	2	441	c.345G>C	c.(343-345)GTG>GTC	p.V115V		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	115	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					ACATCTGTGTGAGCTGGGAGT	0.433													12	55					0	0	0	0	C	159558171	C	C	159558171	2	2	207	1	0	0	0	0	0	0	0	1	767	1277	45	2		2	APCS	1	159558171	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	7370147	159558171	89692450	12	37739											
ITLN1	55600	broad.mit.edu	37	chr1	160850996	160850996	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggaggaagccagtgtccGtgcggtacctcagcagggag	8	7	16	10	2	2	0	1	0	1	0	3	3	3	3	3	4	4	2	3	4	2	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:160850996G>T	uc001fxc.2	-	5	628	c.512C>A	c.(511-513)ACG>AAG	p.T171K		NM_017625	NP_060095	Q8WWA0	ITLN1_HUMAN	intelectin precursor	171	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding	p.T171T(1)|p.T171K(1)		ovary(2)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)	7	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GCCAGTGTCCGTGCGGTACCT	0.562													30	92					1.30897e-18	1.46261e-18	1	0	T	160850996	T	T	160850996	3	4	207	1	0	0	0	0	1	0	0	0	7949	1145	40	3	445	3	ITLN1	1	160850996	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	1292825	160850996	88399625	13	37740											
NUF2	83540	broad.mit.edu	37	chr1	163325191	163325191	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtattgaaaaggcagcagagGactcctatgctaagatagat	15	9	11	6	0	0	4	0	1	0	3	1	5	1	5	1	2	2	4	1	2	6	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:163325191G>T	uc001gcq.1	+	14	1627	c.1327G>T	c.(1327-1329)GAC>TAC	p.D443Y	NUF2_uc001gcr.1_Missense_Mutation_p.D443Y|NUF2_uc009wvc.1_Missense_Mutation_p.D396Y	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	443	Interaction with the C-terminus of NDC80 and the SPBC24-SPBC25 subcomplex.|Potential.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					GGCAGCAGAGGACTCCTATGC	0.338													9	25					0.000442599	0.000470262	1	0	T	163325191	T	T	163325191	3	4	207	1	0	0	0	0	1	0	0	0	10801	1174	41	2	1377	2	NUF2	1	163325191	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	2474195	163325191	85925430	14	37741											
ZC3H11A	9877	broad.mit.edu	37	chr1	203821425	203821425	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatgattttgagaaactaatAtgggagatttcaggaggcaa	15	11	12	3	0	1	3	1	2	0	2	1	7	1	4	0	3	1	1	0	3	4	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:203821425A>G	uc001hac.2	+	20	2947	c.2331A>G	c.(2329-2331)ATA>ATG	p.I777M	ZC3H11A_uc001had.2_Missense_Mutation_p.I777M|ZC3H11A_uc001hae.2_Missense_Mutation_p.I777M|ZC3H11A_uc001haf.2_Missense_Mutation_p.I777M|ZC3H11A_uc010pqm.1_Missense_Mutation_p.I723M	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	777							nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AGAAACTAATATGGGAGATTT	0.468													17	42					0	0	0	0	G	203821425	G	G	203821425	3	3	207	1	0	0	0	0	1	0	0	0	17627	439	16	5	2393	5	ZC3H11A	1	203821425	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	40496234	203821425	45429196	15	37742											
MARK1	4139	broad.mit.edu	37	chr1	220804398	220804398	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaataatgaaagatcgatggAtgaatgttggtcatgaagag	17	10	12	2	1	1	5	1	3	0	2	2	7	1	6	0	2	0	1	0	2	5	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:220804398A>T	uc001hmn.3	+	10	1528	c.931A>T	c.(931-933)ATG>TTG	p.M311L	MARK1_uc009xdw.2_Missense_Mutation_p.M311L|MARK1_uc010pun.1_Missense_Mutation_p.M311L|MARK1_uc001hmm.3_Missense_Mutation_p.M289L	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	311	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		AGATCGATGGATGAATGTTGG	0.338													7	22					0	0	0	0	T	220804398	T	T	220804398	3	4	207	1	0	0	0	0	1	0	0	0	9365	333	12	5	969	5	MARK1	1	220804398	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	16982973	220804398	28446223	16	37743											
TARBP1	6894	broad.mit.edu	37	chr1	234596074	234596074	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgccaaagccttagataGaaacaaaatgggaacagcac	18	7	8	8	0	0	2	0	0	0	2	0	3	0	3	2	1	5	1	2	1	7	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:234596074G>T	uc001hwd.2	-	7	1468	c.1468C>A	c.(1468-1470)CTA>ATA	p.L490I		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	490					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			GCCTTAGATAGAAACAAAATG	0.373													12	36					6.31663e-08	6.83344e-08	1	0	T	234596074	T	T	234596074	3	4	207	1	0	0	0	0	1	0	0	0	15621	933	33	2	3493	2	TARBP1	1	234596074	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	13791676	234596074	14654547	17	37744											
OR11L1	391189	broad.mit.edu	37	chr1	248004351	248004352	+	Missense_Mutation	DNP	GG	TT	TT																															agataactgggttcagcagtGgtgtgaccacagtgtagaag																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:248004351_248004352GG>TT	uc001idn.1	-	1	847_848	c.847_848CC>AA	c.(847-849)CCA>AAA	p.P283K		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GTTCAGCAGTGGTGTGACCACA	0.441													17	59					0	0	0	0	TT	248004352	TT	TT	248004351	3	4	207	1	0	0	0	0	1	0	0	0	10984	1348	47	4	124	4	OR11L1	1	248004351	Missense_Mutation	DNP	GG	TCGA-CV-6952-01A-11D-1912-08	13408277	248004351	1246270	18	37745											
OR2M5	127059	broad.mit.edu	37	chr1	248309150	248309150	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgggatctggagagggtcGtcgcaaagcttttactacct	9	11	12	9	2	1	1	0	0	1	1	3	3	1	2	1	3	3	2	1	3	3	3	rs147580819		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr1:248309150G>A	uc010pze.1	+	1	701	c.701G>A	c.(700-702)CGT>CAT	p.R234H		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GGAGAGGGTCGTCGCAAAGCT	0.463													73	182					0	0	0	0	A	248309150	A	A	248309150	3	1	207	1	0	0	0	0	1	0	0	0	11067	1145	40	1	703	1	OR2M5	1	248309150	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	304799	248309150	941471	19	37746											
ATAD2B	54454	broad.mit.edu	37	chr2	23977087	23977087	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcataatctttacgatgacGgtagatacactgactaagaa	15	11	8	7	2	2	4	1	2	1	2	2	5	2	4	0	1	2	1	0	1	6	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	ecf3e7c5-9513-40ce-90c6-64b9bca806f9	g.chr2:23977087G>C	uc002rek.3	-	27	4591	c.4297C>G	c.(4297-4299)CGT>GGT	p.R1433G	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Missense_Mutation_p.R673G|ATAD2B_uc002rej.3_Missense_Mutation_p.R601G	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1433							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTACGATGACGGTAGATACAC	0.318													3	4					0	0	0	0	C	23977087	C	C	23977087	3	2	207	1	0	0	0	0	1	0	0	0	1074	1116	39	3	87	3	ATAD2B	2	23977087	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08		23977087	219222286	20	37747											
USP34	9736	broad.mit.edu	37	chr2	61415337	61415337	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaatgtcatgttgctgcAtatgactaaagagtcctctg	12	13	8	8	0	2	2	1	1	1	1	3	2	3	2	1	0	2	3	1	0	5	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:61415337A>G	uc002sbe.2	-	80	10563	c.10541T>C	c.(10540-10542)ATG>ACG	p.M3514T	USP34_uc002sbd.2_Missense_Mutation_p.M316T	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3514					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			ATGTTGCTGCATATGACTAAA	0.468													16	68					0	0	0	0	G	61415337	G	G	61415337	3	3	207	1	0	0	0	0	1	0	0	0	17133	217	8	5	103	5	USP34	2	61415337	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	37438250	61415337	181784036	21	37748											
USP34	9736	broad.mit.edu	37	chr2	61515972	61515973	+	Frame_Shift_Ins	INS	-	A	A																															tggatctactgcaaactggcINSatattaacttcagcaagcaa																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:61515972_61515973insA	uc002sbe.2	-	34	4610_4611	c.4588_4589insT	c.(4588-4590)TGCfs	p.C1530fs		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	1530					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TGCAAACTGGCATATTAACTTC	0.411													---	---	---								A	61515973	A	A	61515972	7	5	207	1	0	1	1	0	0	0	0	0	17133	710	25	0	6239	0	USP34	2	61515972	Frame_Shift_Ins	INS	-	TCGA-CV-6952-01A-11D-1912-08	100635	61515972	181683401	22	37749											
ERCC3	2071	broad.mit.edu	37	chr2	128044295	128044295	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttacctggtatggtgtgcacTtcatccaggatcatgaggcc	8	12	11	10	0	2	1	2	1	0	0	3	2	3	2	3	4	2	2	3	4	2	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:128044295T>C	uc002toh.1	-	8	1421	c.1326A>G	c.(1324-1326)GAA>GAG	p.E442E	ERCC3_uc002toe.1_Silent_p.E197E|ERCC3_uc002tof.1_Silent_p.E378E|ERCC3_uc002tog.1_Silent_p.E378E|ERCC3_uc010flx.1_Silent_p.E197E	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	442	Helicase ATP-binding.|DEVH box.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TGGTGTGCACTTCATCCAGGA	0.557			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				23	84					0	0	0	0	C	128044295	C	C	128044295	2	2	207	1	0	0	0	0	0	0	0	1	5238	1606	56	5		5	ERCC3	2	128044295	Silent	SNP	T	TCGA-CV-6952-01A-11D-1912-08	66528323	128044295	115155078	23	37750											
LRP1B	53353	broad.mit.edu	37	chr2	141081531	141081531	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatttaaagctaagtactCtactgaaccatggccaaatt	16	12	5	8	0	1	1	0	1	1	0	1	1	1	1	2	1	4	2	2	1	9	7			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:141081531C>A	uc002tvj.1	-	81	13417	c.12445G>T	c.(12445-12447)GAG>TAG	p.E4149*		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4149	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.E4149*(1)		lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCTAAGTACTCTACTGAACCA	0.289										TSP Lung(27;0.18)			21	55					7.45023e-12	8.24723e-12	1	0	A	141081531	A	A	141081531	4	1	207	1	0	0	0	0	0	1	0	0	9005	922	32	2	1398	2	LRP1B	2	141081531	Nonsense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	13037236	141081531	102117842	24	37751											
LRP1B	53353	broad.mit.edu	37	chr2	141625820	141625821	+	Missense_Mutation	DNP	CC	GG	GG																															aaatttgcatcccagtctgtCcagaaaagaattctaaaaaa																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:141625820_141625821CC>GG	uc002tvj.1	-	26	5153_5154	c.4181_4182GG>CC	c.(4180-4182)TGG>TCC	p.W1394S	LRP1B_uc010fnl.1_Missense_Mutation_p.W576S	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1394	Extracellular (Potential).|LDL-receptor class B 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCCAGTCTGTCCAGAAAAGAAT	0.267										TSP Lung(27;0.18)			9	33					0	0	0	0	GG	141625821	GG	GG	141625820	3	3	207	1	0	0	0	0	1	0	0	0	9005	856	30	2	9881	2	LRP1B	2	141625820	Missense_Mutation	DNP	CC	TCGA-CV-6952-01A-11D-1912-08	544289	141625820	101573553	25	37752											
ZEB2	9839	broad.mit.edu	37	chr2	145156648	145156648	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccagggatggggacctggaAtttgagtactggtagacttt	9	12	14	6	0	0	2	0	1	0	1	1	5	1	5	2	5	1	2	2	5	3	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:145156648A>G	uc002tvu.2	-	8	2586	c.2106T>C	c.(2104-2106)AAT>AAC	p.N702N	ZEB2_uc002tvv.2_Silent_p.N696N|ZEB2_uc010zbm.1_Silent_p.N673N|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Silent_p.N731N	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	702	Homeobox; atypical.					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GGGACCTGGAATTTGAGTACT	0.463													48	155					0	0	0	0	G	145156648	G	G	145156648	2	3	207	1	0	0	0	0	0	0	0	1	17691	98	4	5		5	ZEB2	2	145156648	Silent	SNP	A	TCGA-CV-6952-01A-11D-1912-08	3530828	145156648	98042725	26	37753											
EPC2	26122	broad.mit.edu	37	chr2	149526743	149526743	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgtccccagtatcagaaccGgaagaagaaaatgatcctga	15	8	9	9	1	1	5	1	2	0	3	3	6	3	6	4	1	1	1	4	1	6	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:149526743G>A	uc010zbt.1	+	8	1191	c.1164G>A	c.(1162-1164)CCG>CCA	p.P388P		NM_015630	NP_056445	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2	388					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)		TATCAGAACCGGAAGAAGAAA	0.388													7	14					0	0	0	0	A	149526743	A	A	149526743	2	1	207	1	0	0	0	0	0	0	0	1	5185	1103	39	1		1	EPC2	2	149526743	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	4370095	149526743	93672630	27	37754											
SLC25A12	8604	broad.mit.edu	37	chr2	172644450	172644451	+	Frame_Shift_Ins	INS	-	G	G																															gggtcaccagagatgcagctINSgggacacctttcaggagaaa																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:172644450_172644451insG	uc002uhh.2	-	16	1681_1682	c.1592_1593insC	c.(1591-1593)CCAfs	p.P531fs	SLC25A12_uc010fqh.2_Frame_Shift_Ins_p.P424fs	NM_003705	NP_003696	O75746	CMC1_HUMAN	solute carrier family 25, member 12	531	Helical; Name=5; (Potential).|Solcar 3.				gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	GAGATGCAGCTGGGACACCTTT	0.465													---	---	---								G	172644451	G	G	172644450	7	5	207	1	0	1	1	0	0	0	0	0	14538	1567	55	0	455	0	SLC25A12	2	172644450	Frame_Shift_Ins	INS	-	TCGA-CV-6952-01A-11D-1912-08	23117707	172644450	70554923	28	37755											
PGAP1	80055	broad.mit.edu	37	chr2	197738421	197738421	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaattacctgtccaaagttCagaagctctagattgtagta	13	14	7	7	0	2	2	1	0	1	2	3	2	3	2	2	0	2	4	2	0	7	7			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:197738421C>G	uc002utw.2	-	15	1602	c.1488G>C	c.(1486-1488)CTG>CTC	p.L496L	PGAP1_uc002utx.2_Silent_p.L322L|PGAP1_uc002uty.1_Silent_p.L496L	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	496	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						GTCCAAAGTTCAGAAGCTCTA	0.294													15	48					0	0	0	0	G	197738421	G	G	197738421	2	3	207	1	0	0	0	0	0	0	0	1	11832	813	29	2		2	PGAP1	2	197738421	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	25093971	197738421	45460952	29	37756											
SF3B1	23451	broad.mit.edu	37	chr2	198285204	198285204	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attatcatggtccgcctatgCtttttgtattcatcttcccg	6	18	6	11	2	3	0	2	0	1	0	5	0	5	0	3	1	1	2	3	1	3	7			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:198285204C>T	uc002uue.2	-	4	411	c.363G>A	c.(361-363)AAG>AAA	p.K121K	SF3B1_uc010fsk.1_RNA|SF3B1_uc002uuf.2_Silent_p.K121K|SF3B1_uc002uug.2_Silent_p.K121K	NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	121					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCCGCCTATGCTTTTTGTATT	0.373													23	49					0	0	0	0	T	198285204	T	T	198285204	2	4	207	1	0	0	0	0	0	0	0	1	14214	796	28	4		4	SF3B1	2	198285204	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	546783	198285204	44914169	30	37757											
PSMD1	5707	broad.mit.edu	37	chr2	231944262	231944262	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttacagagataatttggaAtggttagccagagccactaa	14	12	9	6	0	0	2	0	0	0	2	0	4	0	3	2	2	3	1	2	2	5	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:231944262A>G	uc002vrn.1	+	11	1304	c.1173A>G	c.(1171-1173)GAA>GAG	p.E391E	PSMD1_uc002vrm.1_Silent_p.E391E|PSMD1_uc010fxu.1_Silent_p.E255E	NM_002807	NP_002798	Q99460	PSMD1_HUMAN	proteasome 26S non-ATPase subunit 1	391					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	ATAATTTGGAATGGTTAGCCA	0.313													6	21					0	0	0	0	G	231944262	G	G	231944262	2	3	207	1	0	0	0	0	0	0	0	1	12754	98	4	5		5	PSMD1	2	231944262	Silent	SNP	A	TCGA-CV-6952-01A-11D-1912-08	33659058	231944262	11255111	31	37758											
INPP5D	3635	broad.mit.edu	37	chr2	233925301	233925301	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccagcgagtccatctcccGggcatacgcgctctgcgtgc	5	8	12	16	5	2	0	0	0	2	0	4	1	3	0	3	1	5	2	3	1	1	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:233925301G>A	uc010zmo.1	+	1	266	c.113G>A	c.(112-114)CGG>CAG	p.R38Q	INPP5D_uc010zmp.1_Missense_Mutation_p.R38Q	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	38	SH2.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCCATCTCCCGGGCATACGCG	0.617													15	57					0	0	0	0	A	233925301	A	A	233925301	3	1	207	1	0	0	0	0	1	0	0	0	7795	1116	39	1	115	1	INPP5D	2	233925301	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	1981039	233925301	9274072	32	37759											
ASB1	51665	broad.mit.edu	37	chr2	239344474	239344474	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggaagggggccgaggtggAtctggtggacgtaaaaggac	10	5	19	7	3	1	0	0	0	1	0	1	5	1	4	2	8	0	1	2	8	3	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr2:239344474A>G	uc002vyg.2	+	3	400	c.314A>G	c.(313-315)GAT>GGT	p.D105G		NM_001040445	NP_001035535	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box-containing protein	105	ANK 2.				intracellular signal transduction|negative regulation of cytokine biosynthetic process						0		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		GCCGAGGTGGATCTGGTGGAC	0.627													12	29					0	0	0	0	G	239344474	G	G	239344474	3	3	207	1	0	0	0	0	1	0	0	0	1015	333	12	5	324	5	ASB1	2	239344474	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	5419173	239344474	3854899	33	37760											
KIF9	64147	broad.mit.edu	37	chr3	47284589	47284589	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtctgagggaaggggctcaAtgctggaagtttcccggtcc	8	9	15	9	1	2	1	1	1	1	0	4	3	4	3	2	5	1	3	2	5	3	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:47284589A>G	uc010hjp.2	-	17	2265	c.1661T>C	c.(1660-1662)ATT>ACT	p.I554T	KIF9_uc003cqx.2_Missense_Mutation_p.I554T|KIF9_uc003cqy.2_Intron|KIF9_uc011bat.1_Intron|uc003cqw.1_RNA	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2	554					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		AAGGGGCTCAATGCTGGAAGT	0.498													16	41					0	0	0	0	G	47284589	G	G	47284589	3	3	207	1	0	0	0	0	1	0	0	0	8349	101	4	5	735	5	KIF9	3	47284589	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08		47284589	150737841	34	37761											
P4HTM	54681	broad.mit.edu	37	chr3	49042401	49042401	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccatgcccacgtggacagtgGgcctgtgtacccagagacca	9	6	12	14	1	0	1	0	0	0	1	0	3	0	2	5	2	2	1	5	2	1	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:49042401G>A	uc003cvg.2	+	6	1344	c.995G>A	c.(994-996)GGG>GAG	p.G332E	P4HTM_uc003cvh.2_Missense_Mutation_p.G332E|WDR6_uc011bbx.1_5'Flank|WDR6_uc003cvj.2_5'Flank|WDR6_uc011bby.1_5'Flank|WDR6_uc010hkn.2_5'Flank|WDR6_uc011bbz.1_5'Flank	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	332	Lumenal (Potential).|Fe2OG dioxygenase.					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	GTGGACAGTGGGCCTGTGTAC	0.617													26	48					0	0	0	0	A	49042401	A	A	49042401	3	1	207	1	0	0	0	0	1	0	0	0	11414	1232	43	4	1017	4	P4HTM	3	49042401	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	1757812	49042401	148980029	35	37762											
USP19	10869	broad.mit.edu	37	chr3	49155121	49155121	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accacacagtctgtatctgtGaaagcagcatctacatcctc	12	10	6	13	0	3	1	0	1	3	0	5	1	4	1	2	0	3	3	2	0	3	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:49155121G>C	uc003cwd.1	-	4	602	c.441C>G	c.(439-441)TTC>TTG	p.F147L	USP19_uc003cwa.2_5'UTR|USP19_uc003cvz.3_Missense_Mutation_p.F147L|USP19_uc011bcg.1_Missense_Mutation_p.F147L|USP19_uc003cwb.2_Missense_Mutation_p.F132L|USP19_uc003cwc.1_5'Flank|USP19_uc011bch.1_Missense_Mutation_p.F147L|USP19_uc011bci.1_Missense_Mutation_p.F132L	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	147	Cytoplasmic (Potential).|CS 1.				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ctgtatctgtgaaagcagcat	0.408													14	38					0	0	0	0	C	49155121	C	C	49155121	3	2	207	1	0	0	0	0	1	0	0	0	17118	1281	45	2	3607	2	USP19	3	49155121	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	112720	49155121	148867309	36	37763											
PHLDB2	90102	broad.mit.edu	37	chr3	111688671	111688671	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagacctgccgaggattcctCatcaaaatgggtgggaaaat	14	8	11	8	1	2	1	2	0	0	1	3	4	3	3	3	3	1	0	3	3	5	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:111688671C>T	uc010hqa.2	+	16	3861	c.3450C>T	c.(3448-3450)CTC>CTT	p.L1150L	PHLDB2_uc003dyc.2_Silent_p.L1134L|PHLDB2_uc003dyd.2_Silent_p.L1107L|PHLDB2_uc003dyg.2_Silent_p.L1150L|PHLDB2_uc003dyh.2_Silent_p.L1107L|PHLDB2_uc003dyi.2_Silent_p.L641L|PHLDB2_uc003dyj.2_Silent_p.L205L	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1150	PH.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GAGGATTCCTCATCAAAATGG	0.418													18	78					0	0	0	0	T	111688671	T	T	111688671	2	4	207	1	0	0	0	0	0	0	0	1	11907	813	29	2		2	PHLDB2	3	111688671	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	62533550	111688671	86333759	37	37764											
KALRN	8997	broad.mit.edu	37	chr3	124175521	124175521	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggatcgggaggtcaagctgcGggacgccaaccacgaagtca	11	4	15	11	4	2	0	2	0	0	0	3	4	2	3	2	4	3	1	2	4	3	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:124175521G>T	uc003ehg.2	+	23	3921	c.3794G>T	c.(3793-3795)CGG>CTG	p.R1265L	KALRN_uc010hrv.1_Missense_Mutation_p.R1256L|KALRN_uc003ehf.1_Missense_Mutation_p.R1265L|KALRN_uc011bjy.1_Missense_Mutation_p.R1256L|KALRN_uc003ehh.1_Missense_Mutation_p.R611L	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1265					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GTCAAGCTGCGGGACGCCAAC	0.547													4	74					0.00909568	0.00962121	1	0	T	124175521	T	T	124175521	3	4	207	1	0	0	0	0	1	0	0	0	8014	1116	39	3	3884	3	KALRN	3	124175521	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	12486850	124175521	73846909	38	37765											
ZBTB38	253461	broad.mit.edu	37	chr3	141162473	141162473	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttagaaaactatcctaccAttggacaaaatggaggttca	15	12	7	7	0	1	1	1	0	0	1	2	3	2	3	2	3	2	1	2	3	7	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:141162473A>G	uc003etw.2	+	8	2225	c.1243A>G	c.(1243-1245)ATT>GTT	p.I415V	ZBTB38_uc010hun.2_Missense_Mutation_p.I412V|ZBTB38_uc010huo.2_Missense_Mutation_p.I415V|ZBTB38_uc003ety.2_Missense_Mutation_p.I415V|ZBTB38_uc010hup.2_Missense_Mutation_p.I416V	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	415					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CTATCCTACCATTGGACAAAA	0.448													27	77					0	0	0	0	G	141162473	G	G	141162473	3	3	207	1	0	0	0	0	1	0	0	0	17606	217	8	5	1245	5	ZBTB38	3	141162473	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	16986952	141162473	56859957	39	37766											
GRK7	131890	broad.mit.edu	37	chr3	141499575	141499575	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagcctgagaatgtgcttctGgatgacctcggcaactgcag	10	9	12	10	1	1	2	0	2	1	1	2	4	1	3	2	2	4	3	2	2	3	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:141499575G>T	uc011bnd.1	+	2	1056	c.972G>T	c.(970-972)CTG>CTT	p.L324L		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	324	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						ATGTGCTTCTGGATGACCTCG	0.587													6	27					0.000157383	0.000168726	1	0	T	141499575	T	T	141499575	2	4	207	1	0	0	0	0	0	0	0	1	6833	1335	47	4		4	GRK7	3	141499575	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	337102	141499575	56522855	40	37767											
AADAC	13	broad.mit.edu	37	chr3	151532078	151532078	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaacgcacatctgaaaactaTacaaaatttggtaagtttgg	17	11	7	6	1	1	1	0	1	1	0	1	1	1	1	0	2	3	3	0	2	8	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:151532078T>C	uc003eze.2	+	1	218	c.128T>C	c.(127-129)ATA>ACA	p.I43T		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	43	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CTGAAAACTATACAAAATTTG	0.348													3	21					0	0	0	0	C	151532078	C	C	151532078	3	2	207	1	0	0	0	0	1	0	0	0	10	1406	49	5	130	5	AADAC	3	151532078	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	10032503	151532078	46490352	41	37768											
SI	6476	broad.mit.edu	37	chr3	164735778	164735778	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccattgcattgctgttgagtAagaaaacaccatgagcattg	13	11	9	8	0	0	3	0	2	0	1	0	3	0	3	2	0	4	5	2	0	3	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:164735778A>T	uc003fei.2	-	29	3562	c.3500T>A	c.(3499-3501)TTA>TAA	p.L1167*		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1167	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity	p.L1167*(1)		ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GCTGTTGAGTAAGAAAACACC	0.338										HNSCC(35;0.089)			26	31					0	0	0	0	T	164735778	T	T	164735778	4	4	207	1	0	0	0	0	0	1	0	0	14362	372	13	5	2063	5	SI	3	164735778	Nonsense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	13203700	164735778	33286652	42	37769											
CLDN11	5010	broad.mit.edu	37	chr3	170150427	170150427	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attggtgctgtgctgtgcctCgtgggtggctgtgtcatcct	2	15	15	9	1	1	0	1	0	0	0	3	0	2	0	2	3	3	3	2	3	0	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:170150427C>T	uc003fgx.2	+	3	709	c.507C>T	c.(505-507)CTC>CTT	p.L169L	CLDN11_uc011bpt.1_Intron|CLDN11_uc003fgy.2_Silent_p.L85L	NM_005602	NP_005593	O75508	CLD11_HUMAN	claudin 11	169	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			central_nervous_system(1)	1	all_cancers(22;5.62e-23)|all_epithelial(15;7.54e-28)|all_lung(20;2.51e-17)|Lung NSC(18;1.02e-16)|Ovarian(172;0.000567)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TGCTGTGCCTCGTGGGTGGCT	0.592													31	131					0	0	0	0	T	170150427	T	T	170150427	2	4	207	1	0	0	0	0	0	0	0	1	3488	871	31	1		1	CLDN11	3	170150427	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	5414649	170150427	27872003	43	37770											
FNDC3B	64778	broad.mit.edu	37	chr3	172070689	172070689	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tctccactctctgtgtcctgGaggaggagccccttgatgcc	5	11	11	14	0	2	1	0	1	2	0	5	4	3	4	5	3	2	0	5	3	0	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:172070689G>C	uc003fhy.2	+	22	2783	c.2611G>C	c.(2611-2613)GAG>CAG	p.E871Q	FNDC3B_uc003fhz.3_Missense_Mutation_p.E871Q	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	871	Fibronectin type-III 7.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		CTGTGTCCTGGAGGAGGAGCC	0.567													26	68					0	0	0	0	C	172070689	C	C	172070689	3	2	207	1	0	0	0	0	1	0	0	0	6002	1175	41	2	2693	2	FNDC3B	3	172070689	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	1920262	172070689	25951741	44	37771											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			11	59					0	0	0	0	A	178936082	A	A	178936082	3	1	207	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	6865393	178936082	19086348	45	37772											
ZNF595	152687	broad.mit.edu	37	chr4	86787	86787	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaagcctttacacggtccAcaacactgaacgaacataag	16	6	7	12	2	0	1	0	1	0	0	1	2	1	1	2	1	5	1	2	1	6	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr4:86787A>G	uc003fzv.1	+	6	1549	c.1393A>G	c.(1393-1395)ACA>GCA	p.T465A	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_Missense_Mutation_p.T233A|ZNF595_uc011but.1_Missense_Mutation_p.T233A	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	465					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TACACGGTCCACAACACTGAA	0.393													7	23					0	0	0	0	G	86787	G	G	86787	3	3	207	1	0	0	0	0	1	0	0	0	18092	146	6	5	1406	5	ZNF595	4	86787	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08		86787	191067489	46	37773											
ZAR1	326340	broad.mit.edu	37	chr4	48496198	48496198	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccccaccgtcaagatttgtgCggtagatgcaaaggcaaacg	12	7	11	11	3	1	2	1	0	0	2	1	2	1	2	3	2	3	3	3	2	4	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr4:48496198C>T	uc003gyd.2	+	4	1212	c.1212C>T	c.(1210-1212)TGC>TGT	p.C404C		NM_175619	NP_783318	Q86SH2	ZAR1_HUMAN	zygote arrest 1	404					multicellular organismal development	cytoplasm|membrane	bile acid:sodium symporter activity				0						AAGATTTGTGCGGTAGATGCA	0.478													14	62					0	0	0	0	T	48496198	T	T	48496198	2	4	207	1	0	0	0	0	0	0	0	1	17583	776	27	1		1	ZAR1	4	48496198	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	48409411	48496198	142658078	47	37774											
ANKRD17	26057	broad.mit.edu	37	chr4	74007554	74007554	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagtgcttgaactggtacacGaggagcctaagacaaaggac	14	6	12	9	1	0	2	0	1	0	1	0	5	0	4	1	3	4	2	1	3	4	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr4:74007554G>C	uc003hgp.2	-	14	2353	c.2236C>G	c.(2236-2238)CGT>GGT	p.R746G	ANKRD17_uc003hgo.2_Missense_Mutation_p.R633G|ANKRD17_uc003hgq.2_Missense_Mutation_p.R746G|ANKRD17_uc003hgr.2_Missense_Mutation_p.R746G|ANKRD17_uc011cbd.1_Missense_Mutation_p.R311G	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	746					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ACTGGTACACGAGGAGCCTAA	0.418													7	27					0	0	0	0	C	74007554	C	C	74007554	3	2	207	1	0	0	0	0	1	0	0	0	646	1058	37	3	5659	3	ANKRD17	4	74007554	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	25511356	74007554	117146722	48	37775											
CXCL9	4283	broad.mit.edu	37	chr4	76928561	76928572	+	In_Frame_Del	DEL	CAAGATGATGCC	-	-																															tgcactccaatcagaaccagCaagatgatgcccaagaggaa																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr4:76928561_76928572delCAAGATGATGCC	uc003hjh.1	-	1	70_81	c.31_42delGGCATCATCTTG	c.(31-42)GGCATCATCTTGdel	p.GIIL11del		NM_002416	NP_002407	Q07325	CXCL9_HUMAN	small inducible cytokine B9 precursor	11_14					cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCAGAACCAGCAAGATGATGCCCAAGAGGAAA	0.396													---	---	---								-	76928572	-	-	76928561	7	5	207	1	0	1	0	1	0	0	0	0	4106	709	25	0	351	0	CXCL9	4	76928561	In_Frame_Del	DEL	CAAGATGATGCC	TCGA-CV-6952-01A-11D-1912-08	2921007	76928561	114225715	49	37776											
ART3	419	broad.mit.edu	37	chr4	77033553	77033553	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	taacagctccaggtccagttCctgttccaggtcccaaaagc	10	9	8	14	0	0	0	0	0	0	0	5	0	5	0	5	2	3	3	5	2	3	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr4:77033553C>T	uc003hjo.2	+	12	1170	c.1051C>T	c.(1051-1053)CCT>TCT	p.P351S	ART3_uc003hjk.2_Missense_Mutation_p.P329S|ART3_uc003hjn.2_Missense_Mutation_p.P340S|ART3_uc003hjp.2_RNA|ART3_uc010ijb.2_RNA|ART3_uc003hjq.2_RNA|ART3_uc003hjr.2_Missense_Mutation_p.P332S|ART3_uc010ijc.2_Missense_Mutation_p.P310S|ART3_uc010ijd.2_Missense_Mutation_p.P310S	NM_001130016	NP_001123488	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3 isoform a	351					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			ovary(2)	2			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AGGTCCAGTTCCTGTTCCAGG	0.403													22	72					0	0	0	0	T	77033553	T	T	77033553	3	4	207	1	0	0	0	0	1	0	0	0	1000	855	30	2	1093	2	ART3	4	77033553	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	104992	77033553	114120723	50	37777											
FRAS1	80144	broad.mit.edu	37	chr4	79455676	79455676	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcacttaacactgaatttCagctctgcaataatgagaag	15	12	6	8	0	3	2	2	2	1	1	3	3	3	2	0	0	3	2	0	0	5	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr4:79455676C>G	uc003hlb.2	+	71	11439	c.10999C>G	c.(10999-11001)CAG>GAG	p.Q3667E		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3662	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CACTGAATTTCAGCTCTGCAA	0.418													42	115					0	0	0	0	G	79455676	G	G	79455676	3	3	207	1	0	0	0	0	1	0	0	0	6076	827	29	2	11356	2	FRAS1	4	79455676	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	2422123	79455676	111698600	51	37778											
FAT1	2195	broad.mit.edu	37	chr4	187525003	187525003	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcccaatgacgccacctgaGtattcttctccagaagaggt	10	11	8	12	1	2	4	0	2	2	2	4	4	3	4	4	1	0	1	4	1	3	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr4:187525003G>C	uc003izf.2	-	19	10865	c.10677C>G	c.(10675-10677)TAC>TAG	p.Y3559*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3559	Extracellular (Potential).|Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CGCCACCTGAGTATTCTTCTC	0.468										HNSCC(5;0.00058)			15	23					0	0	0	0	C	187525003	C	C	187525003	4	2	207	1	0	0	0	0	0	1	0	0	5721	1024	36	4	3125	4	FAT1	4	187525003	Nonsense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	108069327	187525003	3629273	52	37779											
ZFYVE16	9765	broad.mit.edu	37	chr5	79734575	79734575	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgttccaatcacttgtgctAtagattctacagctgatcca	10	15	6	10	0	2	2	1	1	1	1	4	2	4	2	2	0	3	3	2	0	4	7			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr5:79734575A>G	uc003kgr.3	+	4	2373	c.2071A>G	c.(2071-2073)ATA>GTA	p.I691V	ZFYVE16_uc010jak.1_Missense_Mutation_p.I691V|ZFYVE16_uc003kgp.2_Missense_Mutation_p.I691V|ZFYVE16_uc003kgq.3_Missense_Mutation_p.I691V|ZFYVE16_uc003kgs.3_Missense_Mutation_p.I691V	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	691					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		CACTTGTGCTATAGATTCTAC	0.388													16	35					0	0	0	0	G	79734575	G	G	79734575	3	3	207	1	0	0	0	0	1	0	0	0	17731	449	16	5	2077	5	ZFYVE16	5	79734575	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08		79734575	101180685	53	37780											
SLCO6A1	133482	broad.mit.edu	37	chr5	101834543	101834543	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtgccgggcgacgcctacGaacatggctcaccctgggcg	7	5	15	14	5	1	0	1	0	0	0	1	3	1	0	3	3	3	1	3	3	2	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr5:101834543G>A	uc003knn.2	-	1	178	c.6C>T	c.(4-6)TTC>TTT	p.F2F	SLCO6A1_uc003kno.2_Silent_p.F2F|SLCO6A1_uc003knp.2_Silent_p.F2F|SLCO6A1_uc003knq.2_Silent_p.F2F	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	2	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CGACGCCTACGAACATGGCTC	0.711													31	140					0	0	0	0	A	101834543	A	A	101834543	2	1	207	1	0	0	0	0	0	0	0	1	14796	1049	37	1		1	SLCO6A1	5	101834543	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	22099968	101834543	79080717	54	37781											
RAPGEF6	51735	broad.mit.edu	37	chr5	130764620	130764620	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttcgctatctgcatcagtCacatctcctagtttaggatg	8	14	8	11	1	4	0	2	0	2	0	6	1	4	1	1	1	1	4	1	1	3	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr5:130764620C>G	uc003kvn.1	-	27	4961	c.4755G>C	c.(4753-4755)GTG>GTC	p.V1585V	RAPGEF6_uc003kvp.1_Silent_p.V1635V|RAPGEF6_uc003kvo.1_Intron|RAPGEF6_uc010jdi.1_Silent_p.V1593V|RAPGEF6_uc010jdj.1_Intron|RAPGEF6_uc003kvm.1_Silent_p.V508V	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	1585					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CTGCATCAGTCACATCTCCTA	0.418													22	74					0	0	0	0	G	130764620	G	G	130764620	2	3	207	1	0	0	0	0	0	0	0	1	13113	813	29	2		2	RAPGEF6	5	130764620	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	28930077	130764620	50150640	55	37782											
AFF4	27125	broad.mit.edu	37	chr5	132222032	132222032	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgtcagtgtctttgagtaCttcagagcattttccttctt	6	19	7	9	0	5	2	2	1	3	1	6	2	6	2	1	0	2	2	1	0	1	7			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr5:132222032C>T	uc003kyd.2	-	18	3477	c.3069G>A	c.(3067-3069)AAG>AAA	p.K1023K	AFF4_uc011cxk.1_Silent_p.K701K	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	1023					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCTTTGAGTACTTCAGAGCAT	0.473													38	82					0	0	0	0	T	132222032	T	T	132222032	2	4	207	1	0	0	0	0	0	0	0	1	359	564	20	4		4	AFF4	5	132222032	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	1457412	132222032	48693228	56	37783											
PHF15	23338	broad.mit.edu	37	chr5	133896507	133896507	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaccctgtgccaccagaatAtggccagggccattgagacg	11	6	12	12	1	0	3	0	1	0	3	0	4	0	3	5	2	1	0	5	2	2	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr5:133896507A>G	uc003kzo.1	+	6	723	c.544A>G	c.(544-546)ATG>GTG	p.M182V	PHF15_uc011cxt.1_Missense_Mutation_p.M182V|PHF15_uc003kzk.2_Missense_Mutation_p.M198V|PHF15_uc003kzl.2_Missense_Mutation_p.M182V|PHF15_uc003kzm.2_Missense_Mutation_p.M182V|PHF15_uc003kzn.2_Missense_Mutation_p.M182V	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	182					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCACCAGAATATGGCCAGGGC	0.617													10	31					0	0	0	0	G	133896507	G	G	133896507	3	3	207	1	0	0	0	0	1	0	0	0	11881	449	16	5	562	5	PHF15	5	133896507	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	1674475	133896507	47018753	57	37784											
C5orf24	134553	broad.mit.edu	37	chr5	134190804	134190804	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agactacaagtggcagaagcAtagaaataaaagatgaacta	21	6	9	5	0	0	5	0	1	0	4	0	5	0	5	0	1	3	2	0	1	9	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr5:134190804A>G	uc003kzx.2	+	2	275	c.214A>G	c.(214-216)ATA>GTA	p.I72V	C5orf24_uc003kzy.3_Missense_Mutation_p.I72V|C5orf24_uc003kzz.2_Missense_Mutation_p.I72V	NM_152409	NP_689622	Q7Z6I8	CE024_HUMAN	hypothetical protein LOC134553	72											0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGGCAGAAGCATAGAAATAAA	0.453													28	55					0	0	0	0	G	134190804	G	G	134190804	3	3	207	1	0	0	0	0	1	0	0	0	2297	217	8	5	216	5	C5orf24	5	134190804	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	294297	134190804	46724456	58	37785											
ARHGAP26	23092	broad.mit.edu	37	chr5	142513667	142513667	+	Frame_Shift_Del	DEL	A	-	-																															acaccgttcagtcaacagagAaacgtgagtctttgctgcat																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr5:142513667delA	uc011dbj.1	+	19	1869	c.1834delA	c.(1834-1836)AAAfs	p.K612fs	ARHGAP26_uc003lmt.2_Frame_Shift_Del_p.K612fs|ARHGAP26_uc003lmw.2_Frame_Shift_Del_p.K612fs	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	612	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTCAACAGAGAAACGTGAGTC	0.587													---	---	---								-	142513667	-	-	142513667	7	5	207	1	0	1	0	1	0	0	0	0	875	247	9	0	1908	0	ARHGAP26	5	142513667	Frame_Shift_Del	DEL	A	TCGA-CV-6952-01A-11D-1912-08	8322863	142513667	38401593	59	37786											
ODZ2	57451	broad.mit.edu	37	chr5	167655115	167655115	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattaaaggcaaagtcaccAtctttggcaggaagctccgg	13	8	11	9	1	2	1	1	0	1	1	3	2	3	2	2	4	1	3	2	4	4	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr5:167655115A>G	uc010jjd.2	+	25	5473	c.5473A>G	c.(5473-5475)ATC>GTC	p.I1825V	ODZ2_uc003lzr.3_Missense_Mutation_p.I1595V|ODZ2_uc003lzt.3_Missense_Mutation_p.I1198V|ODZ2_uc010jje.2_Missense_Mutation_p.I1089V	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CAAAGTCACCATCTTTGGCAG	0.498													9	15					0	0	0	0	G	167655115	G	G	167655115	3	3	207	1	0	0	0	0	1	0	0	0	10889	217	8	5	5571	5	ODZ2	5	167655115	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	25141448	167655115	13260145	60	37787											
FOXI1	2299	broad.mit.edu	37	chr5	169535280	169535280	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagctccccagagaagcggCcctcccctcccccatcaggc	7	4	8	22	1	1	1	1	0	0	1	4	2	4	1	8	2	2	1	8	2	1	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr5:169535280C>T	uc003mai.3	+	2	847	c.802C>T	c.(802-804)CCC>TCC	p.P268S	FOXI1_uc003maj.3_Intron	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	268					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGAGAAGCGGCCCTCCCCTCC	0.647									Pendred_syndrome				17	63					0	0	0	0	T	169535280	T	T	169535280	3	4	207	1	0	0	0	0	1	0	0	0	6043	739	26	4	808	4	FOXI1	5	169535280	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	1880165	169535280	11379980	61	37788											
ERVFRDE1	405754	broad.mit.edu	37	chr6	11105000	11105000	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttatctagcaaagttccctGaggaaaagtaatatttggag	14	13	9	5	0	1	1	0	1	1	0	2	3	2	3	1	2	1	3	1	2	7	7			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr6:11105000G>A	uc003mzt.2	-	2	914	c.544C>T	c.(544-546)CAG>TAG	p.Q182*	LOC221710_uc003mzr.2_Intron|LOC221710_uc011dio.1_Intron	NM_207582	NP_997465	P60508	EFRD1_HUMAN	syncytin 2	182	Extracellular (Potential).					integral to membrane|plasma membrane|virion					0						AAAGTTCCCTGAGGAAAAGTA	0.453													58	176					0	0	0	0	A	11105000	A	A	11105000	4	1	207	1	0	0	0	0	0	1	0	0	5270	1299	45	2	1076	2	ERVFRDE1	6	11105000	Nonsense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08		11105000	160010067	62	37789											
BTN1A1	696	broad.mit.edu	37	chr6	26509146	26509146	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctacaacatgaatgatggatCtgatatctatactttctcca	13	14	5	9	0	3	3	0	3	3	0	4	4	3	4	1	1	3	0	1	1	6	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr6:26509146C>G	uc003nif.3	+	7	1345	c.1325C>G	c.(1324-1326)TCT>TGT	p.S442C		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	442	B30.2/SPRY.|Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						AATGATGGATCTGATATCTAT	0.517													11	37					0	0	0	0	G	26509146	G	G	26509146	3	3	207	1	0	0	0	0	1	0	0	0	1564	913	32	2	1351	2	BTN1A1	6	26509146	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	15404146	26509146	144605921	63	37790											
VARS	7407	broad.mit.edu	37	chr6	31752260	31752260	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagagcagggtgcgacctGtcagctccttcttatccacc	7	9	11	14	2	2	1	1	0	1	1	4	3	4	1	4	2	3	2	4	2	1	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr6:31752260G>A	uc003nxe.2	-	12	1910	c.1487C>T	c.(1486-1488)ACA>ATA	p.T496I	VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	496					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity	p.T496I(1)		upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GGTGCGACCTGTCAGCTCCTT	0.587													23	60					0	0	0	0	A	31752260	A	A	31752260	3	1	207	1	0	0	0	0	1	0	0	0	17191	1377	48	4	2383	4	VARS	6	31752260	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	5243114	31752260	139362807	64	37791											
PTK7	5754	broad.mit.edu	37	chr6	43096755	43096755	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcatcaagcagccgtcctcCcaggatgcactgcaggggcg	8	7	12	14	2	2	0	2	0	0	0	4	1	4	1	3	3	4	3	3	3	1	1	rs140431672		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr6:43096755C>T	uc003oub.1	+	2	318	c.120C>T	c.(118-120)TCC>TCT	p.S40S	PTK7_uc003ouc.1_Silent_p.S40S|PTK7_uc003oud.1_Silent_p.S40S|PTK7_uc003oue.1_Silent_p.S40S|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Silent_p.S48S|PTK7_uc003oua.2_Silent_p.S40S	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	40	Ig-like C2-type 1.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			AGCCGTCCTCCCAGGATGCAC	0.637													11	50					0	0	0	0	T	43096755	T	T	43096755	2	4	207	1	0	0	0	0	0	0	0	1	12828	610	22	4		4	PTK7	6	43096755	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	11344495	43096755	128018312	65	37792											
RNGTT	8732	broad.mit.edu	37	chr6	89650812	89650812	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaggctctttaggtaatttGagagcatgctgggatggaac	10	13	13	5	0	1	1	0	1	1	1	1	4	1	3	0	4	3	4	0	4	4	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr6:89650812G>C	uc003pmr.2	-	2	372	c.152C>G	c.(151-153)TCA>TGA	p.S51*	RNGTT_uc003pms.2_Nonsense_Mutation_p.S51*|RNGTT_uc011dzu.1_Intron|RNGTT_uc003pmt.2_Nonsense_Mutation_p.S51*	NM_003800	NP_003791	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	51	TPase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.S51*(1)		upper_aerodigestive_tract(1)	1		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		TAGGTAATTTGAGAGCATGCT	0.343													15	60					0	0	0	0	C	89650812	C	C	89650812	4	2	207	1	0	0	0	0	0	1	0	0	13568	1294	45	2	1701	2	RNGTT	6	89650812	Nonsense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	46554057	89650812	81464255	66	37793											
ROS1	6098	broad.mit.edu	37	chr6	117710592	117710592	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcaccgaaagctcctgcggGcggcctggcagagggtgcag	8	4	17	12	3	0	1	0	0	0	1	1	2	1	1	3	4	4	4	3	4	1	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr6:117710592G>A	uc003pxp.1	-	12	1879	c.1680C>T	c.(1678-1680)CGC>CGT	p.R560R	ROS1_uc011ebi.1_Intron|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	560	Fibronectin type-III 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.R560C(1)		lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCTCCTGCGGGCGGCCTGGCA	0.552			T	GOPC|ROS1	glioblastoma|NSCLC								26	83					0	0	0	0	A	117710592	A	A	117710592	2	1	207	1	0	0	0	0	0	0	0	1	13596	1190	42	4		4	ROS1	6	117710592	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	28059780	117710592	53404475	67	37794											
C6orf115	58527	broad.mit.edu	37	chr6	139363993	139363993	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catatccaggagagctgcttCtgcaaggtgttcatgatgat	10	12	11	8	0	2	3	1	2	1	1	3	4	3	3	1	2	3	4	1	2	2	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr6:139363993C>T	uc003qil.2	+	3	399	c.199C>T	c.(199-201)CTG>TTG	p.L67L	C6orf115_uc003qim.2_Silent_p.L67L	NM_021243	NP_067066	Q9P1F3	CF115_HUMAN	hypothetical protein LOC58527	67											0				GBM - Glioblastoma multiforme(68;0.000278)|OV - Ovarian serous cystadenocarcinoma(155;0.000413)		AGAGCTGCTTCTGCAAGGTGT	0.373													34	101					0	0	0	0	T	139363993	T	T	139363993	2	4	207	1	0	0	0	0	0	0	0	1	2332	912	32	2		2	C6orf115	6	139363993	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	21653401	139363993	31751074	68	37795											
GRM1	2911	broad.mit.edu	37	chr6	146720766	146720766	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catgcatgttggcgatggcaAgctgccctgccgctccaaca	8	8	11	14	2	0	0	0	0	0	0	1	1	1	0	3	2	5	5	3	2	2	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr6:146720766A>G	uc010khw.1	+	8	3061	c.2591A>G	c.(2590-2592)AAG>AGG	p.K864R	GRM1_uc010khv.1_Missense_Mutation_p.K864R|GRM1_uc003qll.2_Missense_Mutation_p.K864R|GRM1_uc011edz.1_Missense_Mutation_p.K864R|GRM1_uc011eea.1_Missense_Mutation_p.K864R	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	864	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGCGATGGCAAGCTGCCCTGC	0.493													8	27					0	0	0	0	G	146720766	G	G	146720766	3	3	207	1	0	0	0	0	1	0	0	0	6835	72	3	5	2617	5	GRM1	6	146720766	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	7356773	146720766	24394301	69	37796											
AKAP12	9590	broad.mit.edu	37	chr6	151672243	151672243	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacgagggcagctaccattaTtgaagaaaggtctccttctt	11	11	10	9	1	2	2	0	1	2	1	3	4	2	2	2	2	2	2	2	2	4	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr6:151672243T>C	uc011eep.1	+	4	2957	c.2717T>C	c.(2716-2718)ATT>ACT	p.I906T	AKAP12_uc003qoe.2_Missense_Mutation_p.I906T|AKAP12_uc003qof.2_Missense_Mutation_p.I808T|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.I801T	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	906					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding	p.I906T(1)		large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GCTACCATTATTGAAGAAAGG	0.507													15	41					0	0	0	0	C	151672243	C	C	151672243	3	2	207	1	0	0	0	0	1	0	0	0	448	1493	52	5	2756	5	AKAP12	6	151672243	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	4951477	151672243	19442824	70	37797											
SP8	221833	broad.mit.edu	37	chr7	20824320	20824321	+	Missense_Mutation	DNP	GC	AA	AA																															gggatgtggcagctgtgcagGcccttgcgccgcaagctcgc																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr7:20824320_20824321GC>AA	uc003suy.2	-	3	1302_1303	c.1061_1062GC>TT	c.(1060-1062)GGC>GTT	p.G354V	SP8_uc003suz.2_Missense_Mutation_p.G372V	NM_198956	NP_945194	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor isoform 2	354	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						AGCTGTGCAGGCCCTTGCGCCG	0.718													8	20					0	0	0	0	AA	20824321	AA	AA	20824320	3	1	207	1	0	0	0	0	1	0	0	0	15034	1190	42	4	414	4	SP8	7	20824320	Missense_Mutation	DNP	GC	TCGA-CV-6952-01A-11D-1912-08		20824320	138314343	71	37798											
C7orf36	57002	broad.mit.edu	37	chr7	39606030	39606030	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcggtgatgtcgtgggttCaagcagcctccttgatccag	6	11	12	12	2	1	2	1	2	0	0	5	2	3	2	4	2	2	2	4	2	1	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr7:39606030C>T	uc003thc.3	+	1	22	c.13C>T	c.(13-15)CAA>TAA	p.Q5*		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	5											0						GTCGTGGGTTCAAGCAGCCTC	0.622													15	26					0	0	0	0	T	39606030	T	T	39606030	4	4	207	1	0	0	0	0	0	1	0	0	2401	827	29	2	15	2	C7orf36	7	39606030	Nonsense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	18781710	39606030	119532633	72	37799											
PCLO	27445	broad.mit.edu	37	chr7	82545553	82545553	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgataaggtgaaacttgctGatggtacaaagtttgttgct	11	14	11	5	0	0	3	0	3	0	0	0	3	0	3	0	2	4	5	0	2	4	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr7:82545553G>T	uc003uhx.2	-	7	12038	c.11749C>A	c.(11749-11751)CAG>AAG	p.Q3917K	PCLO_uc003uhv.2_Missense_Mutation_p.Q3917K|PCLO_uc010lec.2_Missense_Mutation_p.Q882K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3848	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GAAACTTGCTGATGGTACAAA	0.463													119	316					3.89651e-80	4.45851e-80	1	0	T	82545553	T	T	82545553	3	4	207	1	0	0	0	0	1	0	0	0	11637	1299	45	2	3772	2	PCLO	7	82545553	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	42939523	82545553	76593110	73	37800											
UFSP1	402682	broad.mit.edu	37	chr7	100486561	100486562	+	Frame_Shift_Del	DEL	CC	-	-																															ctgcactcacctcttgccagCccacccacccagcagcctgt																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr7:100486561_100486562delCC	uc003uxc.3	-	1	778_779	c.331_332delGG	c.(331-333)GGCfs	p.G111fs	uc010lhm.1_5'Flank	NM_001015072	NP_001015072	Q6NVU6	UFSP1_HUMAN	inactive Ufm1-specific protease 1	111											0	Lung NSC(181;0.041)|all_lung(186;0.0581)					CTCTTGCCAGCCCACCCACCCA	0.584													---	---	---								-	100486562	-	-	100486561	7	5	207	1	0	1	0	1	0	0	0	0	17005	739	26	0	100	0	UFSP1	7	100486561	Frame_Shift_Del	DEL	CC	TCGA-CV-6952-01A-11D-1912-08	17941008	100486561	58652102	74	37801											
PRKAR2B	5577	broad.mit.edu	37	chr7	106781346	106781346	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaaaattggtcaaagatgggGagcatgtaattgatcaaggt	16	10	12	3	0	2	2	2	1	0	1	2	3	2	3	0	4	1	2	0	4	5	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr7:106781346G>A	uc003vdx.2	+	5	710	c.535G>A	c.(535-537)GAG>AAG	p.E179K		NM_002736	NP_002727	P31323	KAP3_HUMAN	cAMP-dependent protein kinase, regulatory	179	cAMP 1.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1						CAAAGATGGGGAGCATGTAAT	0.328													7	44					0	0	0	0	A	106781346	A	A	106781346	3	1	207	1	0	0	0	0	1	0	0	0	12568	1175	41	2	553	2	PRKAR2B	7	106781346	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	6294785	106781346	52357317	75	37802											
NDUFA5	4698	broad.mit.edu	37	chr7	123185711	123185711	+	Nonsense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgccttgaagttggtcttctAattttttaacatctggttcc	7	18	7	9	1	3	1	0	1	3	0	4	1	4	1	2	2	1	2	2	2	3	8			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr7:123185711A>C	uc003vks.2	-	4	312	c.203T>G	c.(202-204)TTA>TGA	p.L68*	NDUFA5_uc003vkr.2_RNA	NM_005000	NP_004991	Q16718	NDUA5_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	68					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	TTGGTCTTCTAATTTTTTAAC	0.303													3	82					0	0	0	0	C	123185711	C	C	123185711	4	2	207	1	0	0	0	0	0	1	0	0	10322	372	13	5	155	5	NDUFA5	7	123185711	Nonsense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	16404365	123185711	35952952	76	37803											
NUP205	23165	broad.mit.edu	37	chr7	135279436	135279436	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcttttggaaaatctcctGaaattgctgcttccctctgg	8	14	8	11	0	2	1	0	1	2	0	4	2	3	2	2	2	3	3	2	2	3	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr7:135279436G>C	uc003vsw.2	+	13	2003	c.1972G>C	c.(1972-1974)GAA>CAA	p.E658Q		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	658					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						AAAATCTCCTGAAATTGCTGC	0.463													20	48					0	0	0	0	C	135279436	C	C	135279436	3	2	207	1	0	0	0	0	1	0	0	0	10813	1291	45	2	2022	2	NUP205	7	135279436	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	12093725	135279436	23859227	77	37804											
KIAA1549	57670	broad.mit.edu	37	chr7	138602949	138602949	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatacttgaggatcttcctCaaattcagagaagtctgcta	14	12	7	8	0	4	2	2	1	2	1	5	4	5	3	1	1	2	1	1	1	5	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr7:138602949C>G	uc011kql.1	-	2	1472	c.1423G>C	c.(1423-1425)GAG>CAG	p.E475Q	KIAA1549_uc003vuk.3_Missense_Mutation_p.E425Q|KIAA1549_uc011kqj.1_Missense_Mutation_p.E475Q	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	475						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GGATCTTCCTCAAATTCAGAG	0.483			O	BRAF	pilocytic astrocytoma								14	31					0	0	0	0	G	138602949	G	G	138602949	3	3	207	1	0	0	0	0	1	0	0	0	8283	835	29	2	4505	2	KIAA1549	7	138602949	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	3323513	138602949	20535714	78	37805											
JHDM1D	80853	broad.mit.edu	37	chr7	139810963	139810964	+	Frame_Shift_Ins	INS	-	A	A																															ctaacattgtctggaatttcINSaaaggcatgttcagatacaa																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr7:139810963_139810964insA	uc003vvm.2	-	11	1363_1364	c.1359_1360insT	c.(1357-1362)TTTGAAfs	p.F453fs	JHDM1D_uc010lng.2_RNA	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	453_454					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					TCTGGAATTTCAAAGGCATGTT	0.297													---	---	---								A	139810964	A	A	139810963	7	5	207	1	0	1	1	0	0	0	0	0	7987	835	29	0	1505	0	JHDM1D	7	139810963	Frame_Shift_Ins	INS	-	TCGA-CV-6952-01A-11D-1912-08	1208014	139810963	19327700	79	37806											
DLGAP2	9228	broad.mit.edu	37	chr8	1497609	1497609	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcccactgctaccccgacgcGctgcagagccccttcgggga	6	5	12	18	4	0	1	0	0	0	1	1	3	0	2	5	2	4	3	5	2	1	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:1497609G>A	uc003wpl.2	+	2	847	c.750G>A	c.(748-750)GCG>GCA	p.A250A	DLGAP2_uc003wpm.2_Silent_p.A250A	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	329					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACCCCGACGCGCTGCAGAGCC	0.677													36	65					0	0	0	0	A	1497609	A	A	1497609	2	1	207	1	0	0	0	0	0	0	0	1	4582	1074	38	1		1	DLGAP2	8	1497609	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08		1497609	144866413	80	37807											
VPS37A	137492	broad.mit.edu	37	chr8	17142026	17142026	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaagattgaaagtagctgcAcatgaagctgaggaagaatc	16	7	12	6	0	0	5	0	3	0	2	1	6	0	6	0	1	3	5	0	1	6	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:17142026A>T	uc003wxj.2	+	10	1367	c.1014A>T	c.(1012-1014)GCA>GCT	p.A338A	VPS37A_uc003wxk.2_Silent_p.A313A|VPS37A_uc003wxl.2_Silent_p.A109A	NM_152415	NP_689628	Q8NEZ2	VP37A_HUMAN	hepatocellular carcinoma related protein 1	338	VPS37 C-terminal.				cellular membrane organization|endosome transport|protein transport	centrosome|late endosome membrane|nucleus					0				Colorectal(111;0.0553)|COAD - Colon adenocarcinoma(73;0.212)		AAGTAGCTGCACATGAAGCTG	0.393													27	21					0	0	0	0	T	17142026	T	T	17142026	2	4	207	1	0	0	0	0	0	0	0	1	17273	146	6	5		5	VPS37A	8	17142026	Silent	SNP	A	TCGA-CV-6952-01A-11D-1912-08	15644417	17142026	129221996	81	37808											
STC1	6781	broad.mit.edu	37	chr8	23709899	23709899	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcaacgaaccacttcagcTgaaagagacaaatccatcca	17	5	7	12	1	1	2	1	1	0	1	3	4	3	2	3	1	3	2	3	1	4	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:23709899T>A	uc003xdw.1	-	2	403	c.119_splice	c.e2-1	p.A40_splice		NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor						cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity	p.?(1)		skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		CCACTTCAGCTGAAAGAGACA	0.507													19	34					0	0	0	0	A	23709899	A	A	23709899	5	1	207	1	0	0	0	0	0	0	1	0	15341	1594	55	5	638	5	STC1	8	23709899	Splice_Site	SNP	T	TCGA-CV-6952-01A-11D-1912-08	6567873	23709899	122654123	82	37809											
ZFHX4	79776	broad.mit.edu	37	chr8	77768159	77768159	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tttcatgatcaatcaaggcgGaacggaaggcaccaaaccag	15	6	10	10	2	3	1	3	1	0	0	3	3	3	3	2	4	2	1	2	4	5	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:77768159G>A	uc003yav.2	+	10	9254	c.8867G>A	c.(8866-8868)GGA>GAA	p.G2956E	ZFHX4_uc003yau.1_Missense_Mutation_p.G3001E|ZFHX4_uc003yaw.1_Missense_Mutation_p.G2956E	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2956						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AATCAAGGCGGAACGGAAGGC	0.463										HNSCC(33;0.089)			9	30					0	0	0	0	A	77768159	A	A	77768159	3	1	207	1	0	0	0	0	1	0	0	0	17702	1174	41	2	9036	2	ZFHX4	8	77768159	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	54058260	77768159	68595863	83	37810											
CCNE2	9134	broad.mit.edu	37	chr8	95894373	95894373	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacataccagcatagccaaaTagtttgtatgtgtctggata	14	12	8	7	0	1	0	0	0	1	0	1	1	1	1	2	1	4	3	2	1	7	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:95894373T>C	uc003yhc.2	-	11	1197	c.1088A>G	c.(1087-1089)TAT>TGT	p.Y363C	CCNE2_uc003yhd.2_Missense_Mutation_p.Y363C	NM_057749	NP_477097	O96020	CCNE2_HUMAN	cyclin E2	363					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding				0	Breast(36;8.75e-07)					CATAGCCAAATAGTTTGTATG	0.363													21	76					0	0	0	0	C	95894373	C	C	95894373	3	2	207	1	0	0	0	0	1	0	0	0	2936	1406	49	5	134	5	CCNE2	8	95894373	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	18126214	95894373	50469649	84	37811											
VPS13B	157680	broad.mit.edu	37	chr8	100831673	100831673	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcagattgtgcagttccCatctcaacatccctcattaa	10	13	4	14	0	3	1	3	0	1	1	6	1	5	1	3	0	2	2	3	0	2	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:100831673C>T	uc003yiv.2	+	48	8841	c.8730C>T	c.(8728-8730)CCC>CCT	p.P2910P	VPS13B_uc003yiw.2_Silent_p.P2885P	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2910					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GTGCAGTTCCCATCTCAACAT	0.363													7	60					0	0	0	0	T	100831673	T	T	100831673	2	4	207	1	0	0	0	0	0	0	0	1	17258	581	21	4		4	VPS13B	8	100831673	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	4937300	100831673	45532349	85	37812											
PKHD1L1	93035	broad.mit.edu	37	chr8	110456987	110456987	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaatggatgttggtatcaGggaaactgtcactttgactg	10	13	11	7	0	3	1	3	1	0	0	3	3	3	3	0	3	1	2	0	3	3	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:110456987G>C	uc003yne.2	+	38	4993	c.4889G>C	c.(4888-4890)AGG>ACG	p.R1630T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1630	Extracellular (Potential).|IPT/TIG 8.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTTGGTATCAGGGAAACTGTC	0.413										HNSCC(38;0.096)			67	293					0	0	0	0	C	110456987	C	C	110456987	3	2	207	1	0	0	0	0	1	0	0	0	12027	1000	35	4	5039	4	PKHD1L1	8	110456987	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	9625314	110456987	35907035	86	37813											
CSMD3	114788	broad.mit.edu	37	chr8	114327022	114327022	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccacatgtataaataaatCctgcaacaaaagacaataaa	22	7	3	9	0	0	1	0	0	0	1	1	1	1	1	2	0	2	2	2	0	11	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:114327022C>T	uc003ynu.2	-	2	338	c.179G>A	c.(178-180)GGA>GAA	p.G60E	CSMD3_uc003ynt.2_Missense_Mutation_p.G20E|CSMD3_uc011lhx.1_Missense_Mutation_p.G60E|CSMD3_uc010mcx.1_Missense_Mutation_p.G60E|CSMD3_uc003ynx.3_Missense_Mutation_p.G60E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	60	Helical; (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATAAATAAATCCTGCAACAAA	0.318										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	93					0	0	0	0	T	114327022	T	T	114327022	3	4	207	1	0	0	0	0	1	0	0	0	3963	869	30	2	11224	2	CSMD3	8	114327022	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	3870035	114327022	32037000	87	37814											
MTBP	27085	broad.mit.edu	37	chr8	121475947	121475947	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacagaggattgacaaacagTaccaaacagaattctgtgtt	16	10	8	7	0	1	3	0	1	1	2	1	4	1	4	1	1	4	2	1	1	5	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:121475947T>C	uc003ypc.1	+	10	1038	c.993T>C	c.(991-993)AGT>AGC	p.S331S	MTBP_uc011lie.1_RNA	NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	331					cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			TGACAAACAGTACCAAACAGA	0.343													24	136					0	0	0	0	C	121475947	C	C	121475947	2	2	207	1	0	0	0	0	0	0	0	1	9965	1635	57	5		5	MTBP	8	121475947	Silent	SNP	T	TCGA-CV-6952-01A-11D-1912-08	7148925	121475947	24888075	88	37815											
FAM84B	157638	broad.mit.edu	37	chr8	127569307	127569307	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacttgttgagcaggttctCgggcgtgtaggtactcagcg	6	11	15	9	3	2	1	1	1	1	0	3	1	2	1	0	3	3	6	0	3	2	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:127569307C>A	uc003yrz.1	-	2	612	c.328G>T	c.(328-330)GAG>TAG	p.E110*		NM_174911	NP_777571	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	110						cytoplasm|plasma membrane	protein binding				0	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			AGCAGGTTCTCGGGCGTGTAG	0.617													25	25					3.08376e-08	3.3513e-08	1	0	A	127569307	A	A	127569307	4	1	207	1	0	0	0	0	0	1	0	0	5674	893	31	3	608	3	FAM84B	8	127569307	Nonsense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	6093360	127569307	18794715	89	37816											
PLEC	5339	broad.mit.edu	37	chr8	144993792	144993792	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctggttccgcacggggtcCaccaggaagccagtggccgc	6	5	15	15	4	0	0	0	0	0	0	2	1	2	1	5	5	1	3	5	5	1	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr8:144993792C>T	uc003zaf.1	-	32	10778	c.10608G>A	c.(10606-10608)GTG>GTA	p.V3536V	PLEC_uc003zab.1_Silent_p.V3399V|PLEC_uc003zac.1_Silent_p.V3403V|PLEC_uc003zad.2_Silent_p.V3399V|PLEC_uc003zae.1_Silent_p.V3367V|PLEC_uc003zag.1_Silent_p.V3377V|PLEC_uc003zah.2_Silent_p.V3385V|PLEC_uc003zaj.2_Silent_p.V3426V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3536	Plectin 13.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCACGGGGTCCACCAGGAAGC	0.692													10	26					0	0	0	0	T	144993792	T	T	144993792	2	4	207	1	0	0	0	0	0	0	0	1	12107	581	21	4		4	PLEC	8	144993792	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	17424485	144993792	1370230	90	37817											
SLC24A2	25769	broad.mit.edu	37	chr9	19516220	19516220	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaccaggaacacaaagtaGaggccaaacatgatgaagcc	18	3	9	11	0	0	3	0	2	0	1	0	4	0	4	4	2	3	1	4	2	5	1	rs41270119		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr9:19516220G>C	uc003zoa.1	-	10	1979	c.1917C>G	c.(1915-1917)CTC>CTG	p.L639L	SLC24A2_uc003zob.1_Silent_p.L622L	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	639	Helical; (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		ACACAAAGTAGAGGCCAAACA	0.488													33	207					0	0	0	0	C	19516220	C	C	19516220	2	2	207	1	0	0	0	0	0	0	0	1	14530	929	33	2		2	SLC24A2	9	19516220	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08		19516220	121697211	91	37818											
ZCCHC6	79670	broad.mit.edu	37	chr9	88961250	88961250	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcagtctctcttcagtctCtcctcagcctgctgtaagcc	6	13	7	15	0	5	0	2	0	3	0	8	0	6	0	3	0	4	3	3	0	1	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr9:88961250C>G	uc004aoq.2	-	3	881	c.666G>C	c.(664-666)GAG>GAC	p.E222D	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.E222D|ZCCHC6_uc004aou.2_Missense_Mutation_p.E222D|ZCCHC6_uc004aov.2_Missense_Mutation_p.E222D|ZCCHC6_uc004aow.2_Missense_Mutation_p.E222D	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	222					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TCTTCAGTCTCTCCTCAGCCT	0.423													30	134					0	0	0	0	G	88961250	G	G	88961250	3	3	207	1	0	0	0	0	1	0	0	0	17659	912	32	2	3921	2	ZCCHC6	9	88961250	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	69445030	88961250	52252181	92	37819											
GRIN3A	116443	broad.mit.edu	37	chr9	104433149	104433149	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaatcagggtaaccactctCaagtgtagcttacttggatg	11	12	9	9	0	3	0	3	0	1	0	4	1	3	1	1	2	3	3	1	2	5	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr9:104433149C>G	uc004bbp.1	-	3	2146	c.1545G>C	c.(1543-1545)TTG>TTC	p.L515F	GRIN3A_uc004bbq.1_Missense_Mutation_p.L515F	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	515	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TAACCACTCTCAAGTGTAGCT	0.507													26	142					0	0	0	0	G	104433149	G	G	104433149	3	3	207	1	0	0	0	0	1	0	0	0	6822	825	29	2	1830	2	GRIN3A	9	104433149	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	15471899	104433149	36780282	93	37820											
CYLC2	1539	broad.mit.edu	37	chr9	105767470	105767470	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agatgaaaaaggaggtgcaaAgaaagataacaaaaaagata	25	4	10	2	0	0	5	0	1	0	4	0	6	0	6	0	2	2	1	0	2	9	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr9:105767470A>G	uc004bbs.2	+	5	627	c.557A>G	c.(556-558)AAG>AGG	p.K186R		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	186	3 X approximate tandem repeats.|31 X 3 AA repeats of K-K-X.|2.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				ggaggtgcaaagaaagataac	0.139													6	12					0	0	0	0	G	105767470	G	G	105767470	3	3	207	1	0	0	0	0	1	0	0	0	4159	72	3	5	575	5	CYLC2	9	105767470	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	1334321	105767470	35445961	94	37821											
GLE1	2733	broad.mit.edu	37	chr9	131285595	131285595	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggacaccaagagaagctaaaAgctgagcaccgtcacagagc	16	3	11	11	1	1	3	1	1	0	2	1	5	1	4	2	1	4	3	2	1	4	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr9:131285595A>G	uc004bvj.2	+	5	732	c.618A>G	c.(616-618)AAA>AAG	p.K206K	GLE1_uc004bvi.2_Silent_p.K206K|GLE1_uc010myd.2_5'UTR	NM_001003722	NP_001003722	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator homolog isoform 1	206	Potential.				poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding				0						AGAAGCTAAAAGCTGAGCACC	0.473													3	86					0	0	0	0	G	131285595	G	G	131285595	2	3	207	1	0	0	0	0	0	0	0	1	6472	69	3	5		5	GLE1	9	131285595	Silent	SNP	A	TCGA-CV-6952-01A-11D-1912-08	25518125	131285595	9927836	95	37822											
SARDH	1757	broad.mit.edu	37	chr9	136582547	136582547	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacacctcccagtccaggtCaaagaggccgaaggcaaact	14	4	10	13	1	1	1	1	0	0	1	3	3	3	1	4	3	2	1	4	3	4	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr9:136582547C>A	uc004cep.3	-	8	1185	c.1051G>T	c.(1051-1053)GAC>TAC	p.D351Y	SARDH_uc004ceo.2_Missense_Mutation_p.D351Y|SARDH_uc011mdn.1_Missense_Mutation_p.D351Y|SARDH_uc011mdo.1_Missense_Mutation_p.D183Y	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	351					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CAGTCCAGGTCAAAGAGGCCG	0.597													10	43					2.80697e-09	3.07862e-09	1	0	A	136582547	A	A	136582547	3	1	207	1	0	0	0	0	1	0	0	0	13906	826	29	2	1761	2	SARDH	9	136582547	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	5296952	136582547	4630884	96	37823											
SFMBT2	57713	broad.mit.edu	37	chr10	7214579	7214579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtcggggttgctttcccCgatggggggcttggagatct	3	12	17	9	2	1	1	0	0	1	1	3	3	2	1	2	6	1	4	2	6	0	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr10:7214579C>T	uc009xio.1	-	18	2120	c.2029G>A	c.(2029-2031)GGG>AGG	p.G677R	SFMBT2_uc001ijn.1_Missense_Mutation_p.G677R|SFMBT2_uc010qay.1_Missense_Mutation_p.G512R	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	677					regulation of transcription, DNA-dependent	nucleus		p.G677R(1)		ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						TTGCTTTCCCCGATGGGGGGC	0.517													23	52					0	0	0	0	T	7214579	T	T	7214579	3	4	207	1	0	0	0	0	1	0	0	0	14223	652	23	1	671	1	SFMBT2	10	7214579	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08		7214579	128320168	97	37824											
IPMK	253430	broad.mit.edu	37	chr10	59976032	59976032	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctttacatccattatacaGggcttattaaatttatgggt	12	17	6	6	0	1	0	0	0	1	0	2	0	2	0	1	2	2	1	1	2	7	8			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr10:59976032G>A	uc001jkb.2	-	4	743	c.420C>T	c.(418-420)CCC>CCT	p.P140P		NM_152230	NP_689416	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	140	Substrate binding (By similarity).					nucleus	ATP binding|inositol trisphosphate 6-kinase activity			ovary(1)	1						CCATTATACAGGGCTTATTAA	0.328													9	38					0	0	0	0	A	59976032	A	A	59976032	2	1	207	1	0	0	0	0	0	0	0	1	7831	987	35	4		4	IPMK	10	59976032	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	52761453	59976032	75558715	98	37825											
SGPL1	8879	broad.mit.edu	37	chr10	72631612	72631612	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agctggctgtcaaatacaaaAtaccccttcatgtcgacgct	12	10	7	12	2	2	0	2	0	0	0	3	1	2	0	2	1	3	3	2	1	5	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr10:72631612A>G	uc001jrm.2	+	11	1150	c.928A>G	c.(928-930)ATA>GTA	p.I310V	SGPL1_uc009xqk.2_RNA	NM_003901	NP_003892	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	310	Cytoplasmic (Potential).				apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity				0					Pyridoxal Phosphate(DB00114)	CAAATACAAAATACCCCTTCA	0.433													19	68					0	0	0	0	G	72631612	G	G	72631612	3	3	207	1	0	0	0	0	1	0	0	0	14283	101	4	5	966	5	SGPL1	10	72631612	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	12655580	72631612	62903135	99	37826											
DLG5	9231	broad.mit.edu	37	chr10	79576322	79576322	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctcacctgtcctttctccGctccccgagggacgcggggt	3	10	12	16	4	2	0	1	0	1	0	5	2	4	1	5	3	1	2	5	3	0	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr10:79576322G>A	uc001jzk.2	-	20	4082	c.4012C>T	c.(4012-4014)CGG>TGG	p.R1338W	DLG5_uc001jzi.2_Missense_Mutation_p.R93W|DLG5_uc001jzj.2_Missense_Mutation_p.R753W|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.R942W	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1338					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TCCTTTCTCCGCTCCCCGAGG	0.637													10	64					0	0	0	0	A	79576322	A	A	79576322	3	1	207	1	0	0	0	0	1	0	0	0	4580	1086	38	1	1799	1	DLG5	10	79576322	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	6944710	79576322	55958425	100	37827											
BTAF1	9044	broad.mit.edu	37	chr10	93740247	93740247	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttatacctatactgcctgatAtgctccgacacatttttcag	10	15	5	11	1	1	1	1	1	0	0	2	2	2	1	3	0	4	1	3	0	5	7			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr10:93740247A>T	uc001khr.2	+	15	1785	c.1687A>T	c.(1687-1689)ATG>TTG	p.M563L	BTAF1_uc001khs.1_Missense_Mutation_p.M233L|BTAF1_uc001kht.1_Missense_Mutation_p.M1L	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	563	HEAT 4.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				ACTGCCTGATATGCTCCGACA	0.373													11	45					0	0	0	0	T	93740247	T	T	93740247	3	4	207	1	0	0	0	0	1	0	0	0	1541	449	16	5	1745	5	BTAF1	10	93740247	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	14163925	93740247	41794500	101	37828											
PDE6C	5146	broad.mit.edu	37	chr10	95399902	95399902	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acttcccccttacagagcacGgattgattaaatgtggaata	13	11	8	9	1	0	2	0	1	0	1	1	4	1	4	2	2	2	1	2	2	5	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr10:95399902G>A	uc001kiu.3	+	12	1696	c.1558G>A	c.(1558-1560)GGA>AGA	p.G520R		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	520					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				TACAGAGCACGGATTGATTAA	0.403													30	71					0	0	0	0	A	95399902	A	A	95399902	3	1	207	1	0	0	0	0	1	0	0	0	11701	1117	39	1	1604	1	PDE6C	10	95399902	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	1659655	95399902	40134845	102	37829											
FAM24B	196792	broad.mit.edu	37	chr10	124610029	124610030	+	Frame_Shift_Ins	INS	-	A	A																															taccaccagcgatgacaggcINSataatcactgtatggaggtc																								rs146874803		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr10:124610029_124610030insA	uc001lgt.2	-	3	336_337	c.2_3insT	c.(1-3)ATGfs	p.M1fs	CUZD1_uc001lgs.2_5'UTR|CUZD1_uc010qtz.1_Intron|LOC399815_uc001lgu.3_5'Flank	NM_152644	NP_689857	Q8N5W8	FA24B_HUMAN	hypothetical protein LOC196792 precursor	1						extracellular region					0		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.136)|COAD - Colon adenocarcinoma(40;0.141)		CGATGACAGGCATAATCACTGT	0.5													---	---	---								A	124610030	A	A	124610029	7	5	207	1	0	1	1	0	0	0	0	0	5577	710	25	0	289	0	FAM24B	10	124610029	Frame_Shift_Ins	INS	-	TCGA-CV-6952-01A-11D-1912-08	29210127	124610029	10924718	103	37830											
IKZF5	64376	broad.mit.edu	37	chr10	124758050	124758050	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctttgtccccactaactgatCcagaaatcatgttcacgtga	11	12	6	12	1	2	3	2	2	0	1	4	3	4	3	3	0	1	1	3	0	2	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr10:124758050C>G	uc001lha.2	-	3	391	c.92G>C	c.(91-93)GGA>GCA	p.G31A		NM_022466	NP_071911	Q9H5V7	IKZF5_HUMAN	zinc finger protein, subfamily 1A, 5	31					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		ACTAACTGATCCAGAAATCAT	0.403													19	61					0	0	0	0	G	124758050	G	G	124758050	3	3	207	1	0	0	0	0	1	0	0	0	7657	855	30	2	1179	2	IKZF5	10	124758050	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	148021	124758050	10776697	104	37831											
ODF3	113746	broad.mit.edu	37	chr11	194639	194641	+	5'Flank	DEL	GGG	-	-																															gggacatcaggaacacactcGgggccacagccacacacaca																								rs112126401		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:194639_194641delGGG	uc001lob.2	+						ODF3_uc010qvk.1_5'Flank|ODF3_uc001loc.2_5'Flank	NM_053280	NP_444510	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm				ovary(1)	1		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		GAACACACTCGGGGCCACAGCCA	0.552													---	---	---								-	194641	-	-	194639	6	5	207	0	1	1	0	1	0	0	0	0	10883	1131	39	0		0	ODF3	11	194639	5'Flank	DEL	GGG	TCGA-CV-6952-01A-11D-1912-08		194639	134811877	105	37832											
RIC8A	60626	broad.mit.edu	37	chr11	209939	209939	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagagactgagcgggccaTggagatcctcaaagtgctct	11	7	12	11	1	2	3	1	1	1	2	3	5	3	3	3	2	2	1	3	2	2	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:209939T>C	uc001log.2	+	3	990	c.665T>C	c.(664-666)ATG>ACG	p.M222T	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Missense_Mutation_p.M222T|RIC8A_uc001loh.2_Missense_Mutation_p.M215T	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	222						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		GAGCGGGCCATGGAGATCCTC	0.587													7	33					0	0	0	0	C	209939	C	C	209939	3	2	207	1	0	0	0	0	1	0	0	0	13420	1464	51	5	675	5	RIC8A	11	209939	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	15300	209939	134796577	106	37833											
OR52A1	23538	broad.mit.edu	37	chr11	5173296	5173296	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgtggatgaaccacatttGaagcaagcaggaatcaaaat	16	9	10	6	0	1	2	1	2	0	0	1	4	1	4	1	2	3	2	1	2	6	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:5173296G>A	uc010qyy.1	-	1	304	c.304C>T	c.(304-306)CAA>TAA	p.Q102*		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	102	Helical; Name=3; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AACCACATTTGAAGCAAGCAG	0.458													8	23					0	0	0	0	A	5173296	A	A	5173296	4	1	207	1	0	0	0	0	0	1	0	0	11162	1299	45	2	636	2	OR52A1	11	5173296	Nonsense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	4963357	5173296	129833220	107	37834											
NLRP14	338323	broad.mit.edu	37	chr11	7064378	7064378	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtccccctagtgtgctgggCcgcttgtacttgtctgaagc	5	12	12	12	1	1	1	0	1	1	0	2	1	2	1	3	1	3	3	3	1	3	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:7064378C>A	uc001mfb.1	+	4	1444	c.1121C>A	c.(1120-1122)GCC>GAC	p.A374D		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	374	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GTGTGCTGGGCCGCTTGTACT	0.453													38	109					3.21399e-22	3.64253e-22	1	0	A	7064378	A	A	7064378	3	1	207	1	0	0	0	0	1	0	0	0	10530	739	26	4	1131	4	NLRP14	11	7064378	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	1891082	7064378	127942138	108	37835											
SBF2	81846	broad.mit.edu	37	chr11	10215531	10215531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttccccagaccttctcctGatcctgttaataaaatcaaa	12	14	3	12	0	2	2	1	1	1	1	5	2	4	2	5	0	0	1	5	0	4	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:10215531G>A	uc001mib.2	-	2	197	c.59C>T	c.(58-60)TCA>TTA	p.S20L	SBF2_uc001mif.3_5'UTR	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	20	UDENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding	p.S20L(1)		upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		ACCTTCTCCTGATCCTGTTAA	0.333													3	15					0	0	0	0	A	10215531	A	A	10215531	3	1	207	1	0	0	0	0	1	0	0	0	13924	1294	45	2	5646	2	SBF2	11	10215531	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	3151153	10215531	124790985	109	37836											
NAV2	89797	broad.mit.edu	37	chr11	20136232	20136233	+	Missense_Mutation	DNP	CC	TT	TT																															acaacagcacgagtggcctcCcctgctgcagttacggcctg																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:20136232_20136233CC>TT	uc001mpr.3	+	37	7425_7426	c.7064_7065CC>TT	c.(7063-7065)CCC>CTT	p.P2355L	NAV2_uc001mpp.2_Missense_Mutation_p.P2288L|NAV2_uc009yhx.2_Missense_Mutation_p.P1416L|NAV2_uc009yhz.2_Missense_Mutation_p.P997L|NAV2_uc001mpu.2_Missense_Mutation_p.P790L|NAV2_uc001mpv.2_Missense_Mutation_p.P114L	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	2411						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GAGTGGCCTCCCCTGCTGCAGT	0.614													13	24					0	0	0	0	TT	20136233	TT	TT	20136232	3	4	207	1	0	0	0	0	1	0	0	0	10237	623	22	4	7319	4	NAV2	11	20136232	Missense_Mutation	DNP	CC	TCGA-CV-6952-01A-11D-1912-08	9920701	20136232	114870284	110	37837											
C11orf74	119710	broad.mit.edu	37	chr11	36654876	36654876	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgtttggaactgattcttCagaaaacatttttacctcag	12	15	7	7	0	3	2	2	1	1	1	3	3	3	3	1	1	3	1	1	1	4	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:36654876C>T	uc001mwy.1	+	3	252	c.179C>T	c.(178-180)TCA>TTA	p.S60L	C11orf74_uc010rfd.1_RNA|C11orf74_uc001mww.1_Intron|C11orf74_uc001mwx.1_Intron|C11orf74_uc001mwz.1_Intron|C11orf74_uc010rfe.1_RNA	NM_138787	NP_620142	Q86VG3	CK074_HUMAN	hypothetical protein LOC119710	60											0	all_lung(20;0.226)	all_hematologic(20;0.0118)				ACTGATTCTTCAGAAAACATT	0.338													8	34					0	0	0	0	T	36654876	T	T	36654876	3	4	207	1	0	0	0	0	1	0	0	0	1668	838	29	2	185	2	C11orf74	11	36654876	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	16518644	36654876	98351640	111	37838											
AHNAK	79026	broad.mit.edu	37	chr11	62285788	62285788	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatctccctgcaggcttggTcccctcagtgtcacatctgg	6	11	10	14	0	4	1	2	0	2	1	6	1	5	1	3	3	1	2	3	3	0	1	rs146188257		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:62285788T>C	uc001ntl.2	-	5	16401	c.16101A>G	c.(16099-16101)GGA>GGG	p.G5367G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5367					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GCAGGCTTGGTCCCCTCAGTG	0.547													21	70					0	0	0	0	C	62285788	C	C	62285788	2	2	207	1	0	0	0	0	0	0	0	1	414	1654	58	5		5	AHNAK	11	62285788	Silent	SNP	T	TCGA-CV-6952-01A-11D-1912-08	25630912	62285788	72720728	112	37839											
CTTN	2017	broad.mit.edu	37	chr11	70263146	70263146	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagtggttttggcggcaagtAtggcgtgcaggccgaccgag	7	8	17	9	4	0	0	0	0	0	0	0	2	0	0	2	5	1	4	2	5	2	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:70263146A>G	uc001opv.3	+	8	691	c.485A>G	c.(484-486)TAT>TGT	p.Y162C	CTTN_uc001opu.2_Missense_Mutation_p.Y162C|CTTN_uc001opw.3_Missense_Mutation_p.Y162C	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	162	Cortactin 3.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GGCGGCAAGTATGGCGTGCAG	0.582													26	93					0	0	0	0	G	70263146	G	G	70263146	3	3	207	1	0	0	0	0	1	0	0	0	4061	449	16	5	507	5	CTTN	11	70263146	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	7977358	70263146	64743370	113	37840											
CLPB	81570	broad.mit.edu	37	chr11	72013356	72013356	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcatcactcacctcgtgtcGctcctggaactcggacatgt	7	11	9	14	3	3	0	3	0	0	0	7	2	4	2	2	2	1	1	2	2	1	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:72013356G>A	uc001osj.2	-	11	1299	c.1249C>T	c.(1249-1251)CGA>TGA	p.R417*	CLPB_uc010rqx.1_Nonsense_Mutation_p.R372*|CLPB_uc010rqy.1_Nonsense_Mutation_p.R358*|CLPB_uc001osk.2_Nonsense_Mutation_p.R387*|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Nonsense_Mutation_p.R216*|CLPB_uc001osi.2_Nonsense_Mutation_p.R25*	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	417					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						ACCTCGTGTCGCTCCTGGAAC	0.522													9	56					0	0	0	0	A	72013356	A	A	72013356	4	1	207	1	0	0	0	0	0	1	0	0	3566	1095	38	1	902	1	CLPB	11	72013356	Nonsense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	1750210	72013356	62993160	114	37841											
C2CD3	26005	broad.mit.edu	37	chr11	73803532	73803532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggagattaaaggtctgtattCccacatcctcacgatgctgg	10	11	10	10	1	2	1	1	0	1	1	4	3	4	1	2	3	1	2	2	3	3	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:73803532C>T	uc001ouu.2	-	19	3673	c.3446G>A	c.(3445-3447)GGA>GAA	p.G1149E		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1149						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					GGTCTGTATTCCCACATCCTC	0.423													9	49					0	0	0	0	T	73803532	T	T	73803532	3	4	207	1	0	0	0	0	1	0	0	0	2164	855	30	2	2497	2	C2CD3	11	73803532	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	1790176	73803532	61202984	115	37842											
PRKRIR	5612	broad.mit.edu	37	chr11	76063019	76063019	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcagttgtggtgatcgaTggaaaaaagaacaaacttcc	17	8	10	6	1	0	2	0	1	0	1	2	4	1	3	1	2	3	2	1	2	6	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:76063019T>A	uc001oxh.1	-	5	1175	c.1175A>T	c.(1174-1176)CAT>CTT	p.H392L	PRKRIR_uc010rrz.1_Missense_Mutation_p.H217L	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	392					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						TGGTGATCGATGGAAAAAAGA	0.378													10	36					0	0	0	0	A	76063019	A	A	76063019	3	1	207	1	0	0	0	0	1	0	0	0	12588	1464	51	5	1114	5	PRKRIR	11	76063019	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	2259487	76063019	58943497	116	37843											
DLG2	1740	broad.mit.edu	37	chr11	83874509	83874509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaaattttttcttaccctctCcagtgtaatttcttcaaatt	11	19	2	9	0	4	0	1	0	3	0	5	0	4	0	2	0	1	1	2	0	5	8			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:83874509C>T	uc001paj.2	-	4	607	c.304G>A	c.(304-306)GAG>AAG	p.E102K	DLG2_uc001pai.2_Missense_Mutation_p.E51K|DLG2_uc010rsy.1_Missense_Mutation_p.E69K|DLG2_uc010rsz.1_Missense_Mutation_p.E102K|DLG2_uc010rta.1_Missense_Mutation_p.E102K|DLG2_uc001pak.2_Missense_Mutation_p.E207K|DLG2_uc010rtb.1_Missense_Mutation_p.E69K|DLG2_uc001pal.1_Missense_Mutation_p.E102K|DLG2_uc001pam.1_Missense_Mutation_p.E141K	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	102	PDZ 1.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CTTACCCTCTCCAGTGTAATT	0.308													7	26					0	0	0	0	T	83874509	T	T	83874509	3	4	207	1	0	0	0	0	1	0	0	0	4577	864	30	2	2438	2	DLG2	11	83874509	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	7811490	83874509	51132007	117	37844											
CHORDC1	26973	broad.mit.edu	37	chr11	89944413	89944413	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcttcattccctgatgacaGtttaagtttatcaagtgctt	9	18	6	8	0	3	2	2	2	1	0	4	2	4	2	1	0	1	3	1	0	3	8			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:89944413G>C	uc001pdg.2	-	5	813	c.403C>G	c.(403-405)CTG>GTG	p.L135V	CHORDC1_uc009yvz.2_Missense_Mutation_p.L116V	NM_012124	NP_036256	Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain-containing	135	Interaction with HSP90AA1 and HSP90AB1 (By similarity).				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				CCTGATGACAGTTTAAGTTTA	0.303													18	65					0	0	0	0	C	89944413	C	C	89944413	3	2	207	1	0	0	0	0	1	0	0	0	3380	1020	36	4	623	4	CHORDC1	11	89944413	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	6069904	89944413	45062103	118	37845											
MLL	4297	broad.mit.edu	37	chr11	118368762	118368763	+	Frame_Shift_Ins	INS	-	T	T																															atcactaaagaatgtgcataINStggctgtgatcaggggcaag																								rs140545520		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:118368762_118368763insT	uc001pta.2	+	21	5790_5791	c.5767_5768insT	c.(5767-5769)ATGfs	p.M1923fs	MLL_uc001ptb.2_Frame_Shift_Ins_p.M1926fs	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1923					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GAATGTGCATATGGCTGTGATC	0.406			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---								T	118368763	T	T	118368762	7	5	207	1	0	1	1	0	0	0	0	0	9673	449	16	0	5849	0	MLL	11	118368762	Frame_Shift_Ins	INS	-	TCGA-CV-6952-01A-11D-1912-08	28424349	118368762	16637754	119	37846											
MLL	4297	broad.mit.edu	37	chr11	118375349	118375349	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacctgtggatagtagtgtCtcttcctctatctcagcaga	9	13	9	10	0	3	1	1	0	3	1	6	3	4	2	2	1	2	2	2	1	4	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:118375349C>A	uc001pta.2	+	27	8756	c.8733C>A	c.(8731-8733)GTC>GTA	p.V2911V	MLL_uc001ptb.2_Silent_p.V2914V	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2911					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		ATAGTAGTGTCTCTTCCTCTA	0.478			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								39	117					2.54651e-27	2.89985e-27	1	0	A	118375349	A	A	118375349	2	1	207	1	0	0	0	0	0	0	0	1	9673	900	32	2		2	MLL	11	118375349	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	6587	118375349	16631167	120	37847											
TECTA	7007	broad.mit.edu	37	chr11	120998603	120998603	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaaccagggcttcgtcctCagcaccagccagtgcgtccc	7	7	10	17	2	1	0	1	0	0	0	4	0	3	0	5	1	5	3	5	1	1	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:120998603C>T	uc010rzo.1	+	8	1917	c.1917C>T	c.(1915-1917)CTC>CTT	p.L639L		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	639	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCTTCGTCCTCAGCACCAGCC	0.657													22	69					0	0	0	0	T	120998603	T	T	120998603	2	4	207	1	0	0	0	0	0	0	0	1	15813	813	29	2		2	TECTA	11	120998603	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	2623254	120998603	14007913	121	37848											
SORL1	6653	broad.mit.edu	37	chr11	121348887	121348887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcagacaagttaaactttGgcttgggaaataggagtgaa	14	12	11	4	0	1	2	1	1	0	1	1	4	1	4	0	3	1	2	0	3	6	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr11:121348887G>A	uc001pxx.2	+	3	543	c.463G>A	c.(463-465)GGC>AGC	p.G155S		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	155	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GTTAAACTTTGGCTTGGGAAA	0.453													13	41					0	0	0	0	A	121348887	A	A	121348887	3	1	207	1	0	0	0	0	1	0	0	0	14998	1348	47	4	473	4	SORL1	11	121348887	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	350284	121348887	13657629	122	37849											
SFRS2IP	9169	broad.mit.edu	37	chr12	46320591	46320591	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcccatcttcccttccaccGgggagagtaactatctctgt	7	12	8	14	1	2	1	0	0	2	1	5	2	4	1	4	2	2	1	4	2	2	4	rs112858085		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr12:46320591G>A	uc001rox.2	-	11	3180	c.2893C>T	c.(2893-2895)CGG>TGG	p.R965W	SFRS2IP_uc001row.2_Missense_Mutation_p.R650W|SFRS2IP_uc001roy.1_Missense_Mutation_p.R1039W	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	965	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		CCCTTCCACCGGGGAGAGTAA	0.428													41	138					0	0	0	0	A	46320591	A	A	46320591	3	1	207	1	0	0	0	0	1	0	0	0	14242	1115	39	1	1518	1	SFRS2IP	12	46320591	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08		46320591	87531304	123	37850											
ACVR1B	91	broad.mit.edu	37	chr12	52380658	52380658	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatgaaacactttgactcctTtaaatgtgctgatatttatg	12	17	6	6	0	0	3	0	3	0	0	1	3	1	3	1	0	2	1	1	0	6	7			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr12:52380658T>G	uc001rzn.2	+	7	1235	c.1193T>G	c.(1192-1194)TTT>TGT	p.F398C	ACVR1B_uc001rzl.2_Missense_Mutation_p.F398C|ACVR1B_uc001rzm.2_Missense_Mutation_p.F398C|ACVR1B_uc010snn.1_Missense_Mutation_p.F439C	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	398	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	TTTGACTCCTTTAAATGTGCT	0.408													33	84					0	0	0	0	G	52380658	G	G	52380658	3	3	207	1	0	0	0	0	1	0	0	0	221	1841	64	5	1346	5	ACVR1B	12	52380658	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	6060067	52380658	81471237	124	37851											
AMHR2	269	broad.mit.edu	37	chr12	53823690	53823690	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggattggggcatggccctcCgacgagctgatatttactct	8	11	12	10	2	1	1	0	1	1	0	2	4	2	2	2	4	2	2	2	4	2	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr12:53823690C>T	uc001scx.1	+	9	1294	c.1216C>T	c.(1216-1218)CGA>TGA	p.R406*	AMHR2_uc009zmy.1_Nonsense_Mutation_p.R406*	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	406	Cytoplasmic (Potential).|Protein kinase.		R -> Q (in PMDS2).		Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)	CATGGCCCTCCGACGAGCTGA	0.582									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				16	47					0	0	0	0	T	53823690	T	T	53823690	4	4	207	1	0	0	0	0	0	1	0	0	573	644	23	1	1250	1	AMHR2	12	53823690	Nonsense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	1443032	53823690	80028205	125	37852											
IRAK3	11213	broad.mit.edu	37	chr12	66639014	66639014	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggccggtgtgctgcaacgcGggcaaagttaagaccatcaa	12	6	13	10	3	1	1	1	0	0	1	1	1	1	1	2	3	3	4	2	3	4	1	rs140671957		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr12:66639014G>A	uc001sth.2	+	11	1388	c.1286G>A	c.(1285-1287)CGG>CAG	p.R429Q	IRAK3_uc010ssy.1_Missense_Mutation_p.R368Q	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	429	Protein kinase.		R -> Q (may be associated with ASRT5).		interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		GCTGCAACGCGGGCAAAGTTA	0.438													31	87					0	0	0	0	A	66639014	A	A	66639014	3	1	207	1	0	0	0	0	1	0	0	0	7863	1116	39	1	1328	1	IRAK3	12	66639014	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	12815324	66639014	67212881	126	37853											
C12orf74	338809	broad.mit.edu	37	chr12	93100819	93100819	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtatctccctcctgagcttCagcctgtcaatgaagggtcc	8	11	9	13	0	3	2	2	2	1	0	6	2	5	2	4	1	2	2	4	1	3	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr12:93100819C>T	uc001tch.1	+	2	642	c.412C>T	c.(412-414)CAG>TAG	p.Q138*	C12orf74_uc001tci.2_Nonsense_Mutation_p.Q138*	NM_001037671	NP_001032760	Q32Q52	CL074_HUMAN	hypothetical protein LOC338809	138											0						TCCTGAGCTTCAGCCTGTCAA	0.582													12	50					0	0	0	0	T	93100819	T	T	93100819	4	4	207	1	0	0	0	0	0	1	0	0	1720	827	29	2	414	2	C12orf74	12	93100819	Nonsense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	26461805	93100819	40751076	127	37854											
KNTC1	9735	broad.mit.edu	37	chr12	123078827	123078827	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctttttatttctagatttCttttcaaccagttttcaggc	7	22	4	8	0	5	1	2	0	3	1	5	1	5	1	1	1	1	1	1	1	3	11			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr12:123078827C>G	uc001ucv.2	+	43	4413	c.4250C>G	c.(4249-4251)TCT>TGT	p.S1417C	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1417					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTCTAGATTTCTTTTCAACCA	0.343													21	54					0	0	0	0	G	123078827	G	G	123078827	3	3	207	1	0	0	0	0	1	0	0	0	8467	913	32	2	4416	2	KNTC1	12	123078827	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	29978008	123078827	10773068	128	37855											
VPS37B	79720	broad.mit.edu	37	chr12	123355461	123355461	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttggtcttctttatctgatAggcttcaaagagaacctgga	10	15	9	7	0	4	2	1	1	3	1	4	4	4	3	1	3	1	1	1	3	4	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr12:123355461A>C	uc001udl.2	-	2	362	c.259T>G	c.(259-261)TAT>GAT	p.Y87D		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	87	VPS37 C-terminal.|Interaction with IST1.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		TTTATCTGATAGGCTTCAAAG	0.448													24	79					0	0	0	0	C	123355461	C	C	123355461	3	2	207	1	0	0	0	0	1	0	0	0	17274	420	15	5	610	5	VPS37B	12	123355461	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	276634	123355461	10496434	129	37856											
RIMBP2	23504	broad.mit.edu	37	chr12	130921797	130921797	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcagccgcacaagctccaCggccgtgctgtctgccgtgg	5	6	13	17	5	1	0	0	0	1	0	2	0	2	0	5	2	4	4	5	2	1	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr12:130921797C>T	uc001uil.2	-	10	1809	c.1645G>A	c.(1645-1647)GTG>ATG	p.V549M	RIMBP2_uc001uim.2_Missense_Mutation_p.V457M|RIMBP2_uc001uin.1_Missense_Mutation_p.V208M	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	549	Fibronectin type-III 3.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		ACAAGCTCCACGGCCGTGCTG	0.692													5	4					0	0	0	0	T	130921797	T	T	130921797	3	4	207	1	0	0	0	0	1	0	0	0	13428	536	19	1	1553	1	RIMBP2	12	130921797	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	7566336	130921797	2930098	130	37857											
RIMBP2	23504	broad.mit.edu	37	chr12	130934748	130934748	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgaggggccgcacttacctaTagcgggcaacacagaggtgg	10	5	15	11	3	0	1	0	0	0	1	0	2	0	1	2	5	3	2	2	5	4	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr12:130934748T>C	uc001uil.2	-	6	691	c.527A>G	c.(526-528)TAT>TGT	p.Y176C	RIMBP2_uc001uim.2_Missense_Mutation_p.Y84C	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	176	SH3 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CACTTACCTATAGCGGGCAAC	0.562													4	7					0	0	0	0	C	130934748	C	C	130934748	3	2	207	1	0	0	0	0	1	0	0	0	13428	1406	49	5	2687	5	RIMBP2	12	130934748	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	12951	130934748	2917147	131	37858											
DGKH	160851	broad.mit.edu	37	chr13	42783488	42783488	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccgtacagtgaaaatcactAtatttggtgacgaaggagtc	13	10	11	7	2	1	2	1	2	0	0	2	4	1	3	1	2	1	1	1	2	6	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr13:42783488A>G	uc001uyl.1	+	23	2758	c.2737A>G	c.(2737-2739)ATA>GTA	p.I913V	DGKH_uc010tfh.1_Missense_Mutation_p.I913V|DGKH_uc001uym.1_Missense_Mutation_p.I913V|DGKH_uc010tfi.1_Missense_Mutation_p.I668V|DGKH_uc010tfj.1_Missense_Mutation_p.I768V|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.I768V|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	913					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		GAAAATCACTATATTTGGTGA	0.393													10	38					0	0	0	0	G	42783488	G	G	42783488	3	3	207	1	0	0	0	0	1	0	0	0	4492	449	16	5	2827	5	DGKH	13	42783488	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08		42783488	72386390	132	37859											
SLITRK6	84189	broad.mit.edu	37	chr13	86370532	86370532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattgtgccatctttttcctCacaattgcaaagagaatcac	12	13	5	11	0	3	1	2	0	1	1	4	2	4	1	2	0	2	1	2	0	3	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr13:86370532C>T	uc001vll.1	-	2	571	c.112G>A	c.(112-114)GAG>AAG	p.E38K	SLITRK6_uc010afe.1_5'Flank	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	38	LRRNT 1.|Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCTTTTTCCTCACAATTGCAA	0.398													4	51					0	0	0	0	T	86370532	T	T	86370532	3	4	207	1	0	0	0	0	1	0	0	0	14811	835	29	2	2417	2	SLITRK6	13	86370532	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	43587044	86370532	28799346	133	37860											
MYO16	23026	broad.mit.edu	37	chr13	109699324	109699324	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actccctttcacagaatcttCtatttgtaatgaaaagtaag	14	14	5	8	0	3	2	1	1	2	1	4	2	4	2	1	0	0	2	1	0	6	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr13:109699324C>G	uc001vqt.1	+	24	2917	c.2791C>G	c.(2791-2793)CTA>GTA	p.L931V	MYO16_uc010agk.1_Missense_Mutation_p.L953V|MYO16_uc001vqu.1_Missense_Mutation_p.L731V|MYO16_uc010tjh.1_Missense_Mutation_p.L443V	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	931	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ACAGAATCTTCTATTTGTAAT	0.313													14	46					0	0	0	0	G	109699324	G	G	109699324	3	3	207	1	0	0	0	0	1	0	0	0	10117	912	32	2	2881	2	MYO16	13	109699324	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	23328792	109699324	5470554	134	37861											
MDGA2	161357	broad.mit.edu	37	chr14	47566080	47566080	+	Frame_Shift_Del	DEL	T	-	-																															tcacaatgatgttggtggacTtttttgcagggtttcccaca																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr14:47566080delT	uc001wwj.3	-	6	1161	c.965delA	c.(964-966)AAGfs	p.K322fs	MDGA2_uc001wwi.3_Frame_Shift_Del_p.K93fs|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	322	Ig-like 3.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GTTGGTGGACTTTTTTGCAGG	0.393													---	---	---								-	47566080	-	-	47566080	7	5	207	1	0	1	0	1	0	0	0	0	9460	1609	56	0	1953	0	MDGA2	14	47566080	Frame_Shift_Del	DEL	T	TCGA-CV-6952-01A-11D-1912-08		47566080	59783460	135	37862											
PTPN21	11099	broad.mit.edu	37	chr14	88945670	88945670	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggattagcatggtggcgtccGacagggacttcttatggccg	7	10	15	9	3	1	0	0	0	1	0	2	3	2	2	2	5	1	1	2	5	2	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr14:88945670G>C	uc001xwv.3	-	13	2436	c.2105C>G	c.(2104-2106)TCG>TGG	p.S702W	PTPN21_uc010twc.1_Missense_Mutation_p.S498W	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	702						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GGTGGCGTCCGACAGGGACTT	0.672													15	49					0	0	0	0	C	88945670	C	C	88945670	3	2	207	1	0	0	0	0	1	0	0	0	12851	1059	37	3	1447	3	PTPN21	14	88945670	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	41379590	88945670	18403870	136	37863											
GPR68	8111	broad.mit.edu	37	chr14	91700861	91700861	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atggcgcgctgccatgcctgGatggggtagtgctcaaagca	8	8	15	10	2	1	0	1	0	0	0	1	1	1	1	2	4	4	4	2	4	2	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr14:91700861G>C	uc001xzg.2	-	2	875	c.534C>G	c.(532-534)ATC>ATG	p.I178M	GPR68_uc001xzh.2_Missense_Mutation_p.I188M	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	178	Extracellular (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		GCCATGCCTGGATGGGGTAGT	0.622													3	18					0	0	0	0	C	91700861	C	C	91700861	3	2	207	1	0	0	0	0	1	0	0	0	6745	1164	41	2	567	2	GPR68	14	91700861	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	2755191	91700861	15648679	137	37864											
CASC5	57082	broad.mit.edu	37	chr15	40951562	40951562	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacttttattctctagctccGcagcatttgcaaagtttgaa	10	15	7	9	1	1	1	0	1	1	0	3	2	2	1	1	0	3	5	1	0	4	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr15:40951562G>A	uc010bbs.1	+	26	6978	c.6817G>A	c.(6817-6819)GCA>ACA	p.A2273T	CASC5_uc010bbt.1_Missense_Mutation_p.A2247T	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	2273	Necessary for kinetochore localization and for interaction with NSL1 and DSN1.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		CTCTAGCTCCGCAGCATTTGC	0.328													20	39					0	0	0	0	A	40951562	A	A	40951562	3	1	207	1	0	0	0	0	1	0	0	0	2675	1087	38	1	6915	1	CASC5	15	40951562	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08		40951562	61579830	138	37865											
USP8	9101	broad.mit.edu	37	chr15	50769638	50769638	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttgaaccagttgctgcttCtaaatctgatgtttcaccca	10	14	7	10	0	3	2	1	2	2	0	3	2	3	2	2	0	3	5	2	0	3	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr15:50769638C>G	uc001zym.3	+	11	1660	c.1160C>G	c.(1159-1161)TCT>TGT	p.S387C	USP8_uc001zyk.1_Missense_Mutation_p.S88C|USP8_uc001zyl.3_Missense_Mutation_p.S387C|USP8_uc001zyn.3_Missense_Mutation_p.S387C|USP8_uc010ufh.1_Missense_Mutation_p.S310C|USP8_uc010bev.1_Missense_Mutation_p.S16C	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	387					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		GTTGCTGCTTCTAAATCTGAT	0.343													23	43					0	0	0	0	G	50769638	G	G	50769638	3	3	207	1	0	0	0	0	1	0	0	0	17157	913	32	2	1194	2	USP8	15	50769638	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	9818076	50769638	51761754	139	37866											
ADAMTS7	11173	broad.mit.edu	37	chr15	79058842	79058842	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgggggtggggagcggccGgcctggctaggccaagggct	4	5	23	9	2	0	0	0	0	0	0	0	1	0	1	3	10	1	2	3	10	2	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr15:79058842G>A	uc002bej.3	-	19	3622	c.3411C>T	c.(3409-3411)GCC>GCT	p.A1137A	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1137					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						GGGAGCGGCCGGCCTGGCTAG	0.677													3	15					0	0	0	0	A	79058842	A	A	79058842	2	1	207	1	0	0	0	0	0	0	0	1	271	1103	39	1		1	ADAMTS7	15	79058842	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	28289204	79058842	23472550	140	37867											
SV2B	9899	broad.mit.edu	37	chr15	91835756	91835756	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgattgcccttcgactgccaGagactcgagaacaggtcctg	9	9	11	12	2	0	3	0	1	0	2	3	6	1	3	3	1	3	0	3	1	1	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr15:91835756G>C	uc002bqv.2	+	12	2417	c.2026G>C	c.(2026-2028)GAG>CAG	p.E676Q	SV2B_uc010uqv.1_Missense_Mutation_p.E525Q|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	676	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity	p.E676Q(1)		ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TCGACTGCCAGAGACTCGAGA	0.507													31	82					0	0	0	0	C	91835756	C	C	91835756	3	2	207	1	0	0	0	0	1	0	0	0	15484	943	33	2	2072	2	SV2B	15	91835756	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	12776914	91835756	10695636	141	37868											
LYSMD4	145748	broad.mit.edu	37	chr15	100269526	100269526	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaaataaaagacaggcaaGacaataccaatcagcagcat	21	4	6	10	0	1	2	1	0	0	2	1	2	1	2	2	1	3	3	2	1	7	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr15:100269526G>A	uc002bvk.2	-	3	756	c.693C>T	c.(691-693)GTC>GTT	p.V231V	LYSMD4_uc002bvj.1_Intron|LYSMD4_uc010bou.1_Intron|LYSMD4_uc002bvl.2_Silent_p.V232V|LYSMD4_uc002bvm.2_3'UTR|LYSMD4_uc010bov.2_Silent_p.V231V			Q5XG99	LYSM4_HUMAN	SubName: Full=cDNA FLJ77040, highly similar to Homo sapiens LysM, putative peptidoglycan-binding, domain containing 4, mRNA; SubName: Full=LysM, putative peptidoglycan-binding, domain containing 4, isoform CRA_c;	231	Helical; (Potential).				cell wall macromolecule catabolic process	integral to membrane					0	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00162)|LUSC - Lung squamous cell carcinoma(107;0.17)|Lung(145;0.208)			AGACAGGCAAGACAATACCAA	0.478													44	142					0	0	0	0	A	100269526	A	A	100269526	2	1	207	1	0	0	0	0	0	0	0	1	9178	929	33	2		2	LYSMD4	15	100269526	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	8433770	100269526	2261866	142	37869											
TMCO7	79613	broad.mit.edu	37	chr16	68893913	68893913	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaatctgaaactcctaaGagatgaaattgctgataagg	17	9	10	5	0	1	5	0	3	1	2	2	7	2	5	1	1	2	1	1	1	6	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr16:68893913G>C	uc002ewi.3	+	2	233	c.221G>C	c.(220-222)AGA>ACA	p.R74T	TMCO7_uc002ewh.2_Missense_Mutation_p.R74T	NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	74						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		AAACTCCTAAGAGATGAAATT	0.403													6	51					0	0	0	0	C	68893913	C	C	68893913	3	2	207	1	0	0	0	0	1	0	0	0	16067	942	33	2	227	2	TMCO7	16	68893913	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08		68893913	21460840	143	37870											
ZFP1	162239	broad.mit.edu	37	chr16	75204123	75204123	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aactcttagattacacttgcGaatccacacaggagagaaac	16	8	7	10	1	1	2	0	0	1	2	2	5	2	3	1	1	4	0	1	1	5	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr16:75204123G>A	uc002fdo.2	+	4	1279	c.1115G>A	c.(1114-1116)CGA>CAA	p.R372Q	ZFP1_uc002fdp.2_Missense_Mutation_p.R317Q|ZFP1_uc010cgt.2_Missense_Mutation_p.R339Q|ZFP1_uc010cgs.2_Missense_Mutation_p.R317Q|ZFP1_uc002fdq.2_Missense_Mutation_p.R372Q	NM_153688	NP_710155	Q6P2D0	ZFP1_HUMAN	zinc finger protein 1 homolog	372	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R372Q(1)		upper_aerodigestive_tract(1)|ovary(1)	2						TTACACTTGCGAATCCACACA	0.473													7	55					0	0	0	0	A	75204123	A	A	75204123	3	1	207	1	0	0	0	0	1	0	0	0	17703	1058	37	1	1125	1	ZFP1	16	75204123	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	6310210	75204123	15150630	144	37871											
CHST6	4166	broad.mit.edu	37	chr16	75513142	75513142	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgcaccaggtgcacgatgcgTaggttgagcgcggggtcgct	6	7	17	11	6	0	1	0	1	0	0	1	2	0	1	1	4	3	5	1	4	1	2	rs138994371		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr16:75513142T>C	uc002fef.2	-	3	765	c.585A>G	c.(583-585)CTA>CTG	p.L195L	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.L195L	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	195	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GCACGATGCGTAGGTTGAGCG	0.687													11	44					0	0	0	0	C	75513142	C	C	75513142	2	2	207	1	0	0	0	0	0	0	0	1	3423	1625	57	5		5	CHST6	16	75513142	Silent	SNP	T	TCGA-CV-6952-01A-11D-1912-08	309019	75513142	14841611	145	37872											
MBTPS1	8720	broad.mit.edu	37	chr16	84104310	84104310	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggtagcccgaccaaggccaTaagaccgaggagtaggagaa	15	3	14	9	2	0	2	0	0	0	2	0	6	0	3	4	4	1	2	4	4	5	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr16:84104310T>C	uc002fhi.2	-	13	2167	c.1665A>G	c.(1663-1665)TTA>TTG	p.L555L	MBTPS1_uc002fhh.2_Silent_p.L59L	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	555	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						ACCAAGGCCATAAGACCGAGG	0.522													16	73					0	0	0	0	C	84104310	C	C	84104310	2	2	207	1	0	0	0	0	0	0	0	1	9414	1403	49	5		5	MBTPS1	16	84104310	Silent	SNP	T	TCGA-CV-6952-01A-11D-1912-08	8591168	84104310	6250443	146	37873											
ABR	29	broad.mit.edu	37	chr17	914076	914077	+	In_Frame_Ins	INS	-	TCA	TCA																															ggcgttgatgtccatgtcacINStcagcatcagcaggatgtcc																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr17:914076_914077insTCA	uc002fsd.2	-	20	2238_2239	c.2128_2129insTGA	c.(2128-2130)AGT>ATGAGT	p.709_710insM	ABR_uc002fse.2_In_Frame_Ins_p.663_664insM|ABR_uc010vqf.1_In_Frame_Ins_p.160_161insM|ABR_uc010vqg.1_In_Frame_Ins_p.491_492insM|ABR_uc002fsg.2_In_Frame_Ins_p.672_673insM|ABR_uc002fsh.1_In_Frame_Ins_p.317_318insM|ABR_uc002fsf.2_In_Frame_Ins_p.246_247insM	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	709_710	Rho-GAP.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity	p.S710delS(1)		upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		GTCCATGTCACTCAGCATCAGC	0.634													---	---	---								TCA	914077	TCA	TCA	914076	7	5	207	1	0	1	1	0	0	0	0	0	99	565	20	0	466	0	ABR	17	914076	In_Frame_Ins	INS	-	TCGA-CV-6952-01A-11D-1912-08		914076	80281134	147	37874											
ZFP3	124961	broad.mit.edu	37	chr17	4994843	4994843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattcccaaggaagaaatttCtgaagaatctgagccacatg	15	9	9	8	0	2	4	0	2	2	2	3	6	3	5	2	1	1	0	2	1	5	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr17:4994843C>T	uc002gaq.2	+	2	169	c.44C>T	c.(43-45)TCT>TTT	p.S15F		NM_153018	NP_694563	Q96NJ6	ZFP3_HUMAN	zinc finger protein-3	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAGAAATTTCTGAAGAATCT	0.403													16	15					0	0	0	0	T	4994843	T	T	4994843	3	4	207	1	0	0	0	0	1	0	0	0	17710	913	32	2	46	2	ZFP3	17	4994843	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	4080767	4994843	76200367	148	37875											
TP53	7157	broad.mit.edu	37	chr17	7577114	7577114	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctctcccaggacaggcaCaaacacgcacctcaaagctg	12	5	9	15	1	2	0	1	0	1	0	4	1	3	1	2	3	2	3	2	3	2	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr17:7577114C>A	uc002gim.2	-	8	1018	c.824G>T	c.(823-825)TGT>TTT	p.C275F	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.C275F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C143F|TP53_uc010cng.1_Missense_Mutation_p.C143F|TP53_uc002gii.1_Missense_Mutation_p.C143F|TP53_uc010cnh.1_Missense_Mutation_p.C275F|TP53_uc010cni.1_Missense_Mutation_p.C275F|TP53_uc002gij.2_Missense_Mutation_p.C275F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	275	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C275Y(44)|p.C275F(34)|p.C275G(7)|p.C275W(7)|p.0?(7)|p.C275R(6)|p.C275C(4)|p.C275fs*70(2)|p.C275fs*31(2)|p.?(2)|p.C275S(2)|p.R273_C275delRVC(1)|p.C275_A276ins10(1)|p.V274_P278del(1)|p.C275*(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.A276fs*29(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGACAGGCACAAACACGCAC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	18					1.52009e-12	1.69057e-12	1	0	A	7577114	A	A	7577114	3	1	207	1	0	0	0	0	1	0	0	0	16448	478	17	4	462	4	TP53	17	7577114	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	2582271	7577114	73618096	149	37876											
ZNF286A	57335	broad.mit.edu	37	chr17	15619477	15619477	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagactgacacggaatagtGtctatgactctaacttggaa	14	10	9	8	1	2	3	0	2	2	1	2	5	2	5	0	2	1	0	0	2	5	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr17:15619477G>T	uc010cot.2	+	6	835	c.439G>T	c.(439-441)GTC>TTC	p.V147F	ZNF286A_uc002goz.3_Missense_Mutation_p.V35F|ZNF286A_uc010vwa.1_Missense_Mutation_p.V147F|ZNF286A_uc002gpa.2_Missense_Mutation_p.V147F	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		ACGGAATAGTGTCTATGACTC	0.403													19	20					3.62473e-10	3.99392e-10	1	0	T	15619477	T	T	15619477	3	4	207	1	0	0	0	0	1	0	0	0	17890	1377	48	4	457	4	ZNF286A	17	15619477	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	8042363	15619477	65575733	150	37877											
WIPF2	147179	broad.mit.edu	37	chr17	38433351	38433351	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagatgattttgagtcaaaGtattccttccatccagtaga	12	13	8	8	0	1	4	1	2	0	2	4	4	4	4	3	0	0	3	3	0	3	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr17:38433351G>C	uc002hug.1	+	7	1437	c.1197G>C	c.(1195-1197)AAG>AAC	p.K399N	WIPF2_uc002huh.1_Missense_Mutation_p.K249N|WIPF2_uc010cww.1_Missense_Mutation_p.K249N|WIPF2_uc002hui.1_Missense_Mutation_p.K399N|WIPF2_uc010cwx.1_Missense_Mutation_p.K141N|WIPF2_uc010cwy.1_Missense_Mutation_p.K399N	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	399						cytoplasm|cytoskeleton	actin binding	p.K399N(1)		upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						TTGAGTCAAAGTATTCCTTCC	0.413										HNSCC(43;0.11)			20	78					0	0	0	0	C	38433351	C	C	38433351	3	2	207	1	0	0	0	0	1	0	0	0	17436	1020	36	4	1219	4	WIPF2	17	38433351	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	22813874	38433351	42761859	151	37878											
GFAP	2670	broad.mit.edu	37	chr17	42992693	42992693	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcattgagtgccccagcCagggagaaatccacccgggt	10	5	12	14	1	0	2	0	1	0	1	1	3	1	2	6	2	3	1	6	2	1	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr17:42992693C>T	uc002ihq.2	-	1	222	c.162G>A	c.(160-162)CTG>CTA	p.L54L	GFAP_uc002ihr.2_Silent_p.L54L|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	54	Head.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				GTGCCCCAGCCAGGGAGAAAT	0.657													18	40					0	0	0	0	T	42992693	T	T	42992693	2	4	207	1	0	0	0	0	0	0	0	1	6374	581	21	4		4	GFAP	17	42992693	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	4559342	42992693	38202517	152	37879											
TTLL6	284076	broad.mit.edu	37	chr17	46862375	46862375	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctccaacttcgagctgctGagattgatattcctcagatc	9	12	9	11	1	1	3	1	2	0	2	5	5	3	3	2	1	3	3	2	1	2	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr17:46862375G>A	uc010wlo.1	-	14	1985	c.1950C>T	c.(1948-1950)CTC>CTT	p.L650L	TTLL6_uc002iob.2_Silent_p.L343L|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Silent_p.L403L|TTLL6_uc002iod.2_Silent_p.L497L	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	602						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						TCGAGCTGCTGAGATTGATAT	0.483													72	121					0	0	0	0	A	46862375	A	A	46862375	2	1	207	1	0	0	0	0	0	0	0	1	16799	1277	45	2		2	TTLL6	17	46862375	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	3869682	46862375	34332835	153	37880											
BAHCC1	57597	broad.mit.edu	37	chr17	79410170	79410170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgccatggccatcagcgagGagcgcaaggctggcgcctac	8	4	14	15	4	1	0	1	0	0	0	1	2	1	1	4	4	3	2	4	4	2	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr17:79410170G>A	uc002kaf.2	+	3	1795	c.1795G>A	c.(1795-1797)GAG>AAG	p.E599K	BAHCC1_uc002kae.2_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	599							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CATCAGCGAGGAGCGCAAGGC	0.706													11	30					0	0	0	0	A	79410170	A	A	79410170	3	1	207	1	0	0	0	0	1	0	0	0	1298	1175	41	2	1644	2	BAHCC1	17	79410170	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	32547795	79410170	1785040	154	37881											
EPB41L3	23136	broad.mit.edu	37	chr18	5397422	5397422	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggactccgtcttggtttccaTtttctgcatgggaagagatt	7	15	11	8	1	2	1	0	0	2	1	4	4	4	3	2	3	1	2	2	3	1	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr18:5397422T>C	uc002kmt.1	-	18	2562	c.2476A>G	c.(2476-2478)ATG>GTG	p.M826V	EPB41L3_uc010wzh.1_Missense_Mutation_p.M657V|EPB41L3_uc002kmu.1_Missense_Mutation_p.M604V|EPB41L3_uc010dkq.1_Missense_Mutation_p.M495V|EPB41L3_uc002kms.1_Missense_Mutation_p.M61V|EPB41L3_uc010wze.1_Missense_Mutation_p.M131V|EPB41L3_uc010wzf.1_Missense_Mutation_p.M123V|EPB41L3_uc010wzg.1_Missense_Mutation_p.M98V|EPB41L3_uc010dkr.2_Missense_Mutation_p.M218V	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	826	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TTGGTTTCCATTTTCTGCATG	0.517													32	82					0	0	0	0	C	5397422	C	C	5397422	3	2	207	1	0	0	0	0	1	0	0	0	5178	1493	52	5	807	5	EPB41L3	18	5397422	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08		5397422	72679826	155	37882											
ANKRD30B	374860	broad.mit.edu	37	chr18	14780007	14780007	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggaagatgaagaatattCttgggattctggggtattgt	12	13	14	2	0	2	4	0	1	2	3	2	6	2	6	0	4	0	1	0	4	5	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr18:14780007C>G	uc010dlo.2	+	11	1649	c.1469C>G	c.(1468-1470)TCT>TGT	p.S490C	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	490										ovary(1)|skin(1)	2						GAAGAATATTCTTGGGATTCT	0.313													5	11					0	0	0	0	G	14780007	G	G	14780007	3	3	207	1	0	0	0	0	1	0	0	0	659	913	32	2	1511	2	ANKRD30B	18	14780007	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	9382585	14780007	63297241	156	37883											
DSG3	1830	broad.mit.edu	37	chr18	29055986	29055986	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtccagccagctgtttcCatccctgaccctctgcagca	6	11	7	17	0	2	1	0	1	2	0	5	1	5	1	5	0	4	4	5	0	0	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr18:29055986C>T	uc002kws.2	+	16	2872	c.2763C>T	c.(2761-2763)TCC>TCT	p.S921S	DSG3_uc002kwt.2_Silent_p.S203S	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	921	Desmoglein repeat 1.|Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAGCTGTTTCCATCCCTGACC	0.507													22	70					0	0	0	0	T	29055986	T	T	29055986	2	4	207	1	0	0	0	0	0	0	0	1	4800	581	21	4		4	DSG3	18	29055986	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	14275979	29055986	49021262	157	37884											
NETO1	81832	broad.mit.edu	37	chr18	70461478	70461478	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcccatctcaaactcacaCgctaaataacaaaatgccaa	17	6	3	15	2	2	0	2	0	1	0	3	0	2	0	3	0	3	1	3	0	7	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr18:70461478C>T	uc002lkw.2	-	6	797	c.513G>A	c.(511-513)GCG>GCA	p.A171A	NETO1_uc002lkx.1_Silent_p.A170A|NETO1_uc002lky.1_Silent_p.A171A	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	171	Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CAAACTCACACGCTAAATAAC	0.388													19	61					0	0	0	0	T	70461478	T	T	70461478	2	4	207	1	0	0	0	0	0	0	0	1	10393	550	19	1		1	NETO1	18	70461478	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	41405492	70461478	7615770	158	37885											
SFRS14	10147	broad.mit.edu	37	chr19	19112448	19112448	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttggacatgggacgaccccGaggcctgtcataggcaattc	9	9	12	11	2	1	0	1	0	0	0	2	4	1	2	3	4	0	1	3	4	2	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr19:19112448G>A	uc002nkx.2	-	8	3111	c.2965C>T	c.(2965-2967)CGG>TGG	p.R989W	SFRS14_uc002nkz.1_Missense_Mutation_p.R1003W|SFRS14_uc002nla.1_Missense_Mutation_p.R989W|SFRS14_uc002nlb.2_Missense_Mutation_p.R989W|SFRS14_uc010xqk.1_Missense_Mutation_p.R758W	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	989					mRNA processing|RNA splicing	nucleus	RNA binding	p.R989W(1)			0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			GGACGACCCCGAGGCCTGTCA	0.423													11	62					0	0	0	0	A	19112448	A	A	19112448	3	1	207	1	0	0	0	0	1	0	0	0	14235	1057	37	1	295	1	SFRS14	19	19112448	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08		19112448	40016535	159	37886											
ZNF345	25850	broad.mit.edu	37	chr19	37368294	37368294	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcctttagttttgaatcaGcccttattcggcatcacaga	10	14	7	10	1	2	2	2	1	0	1	4	2	3	2	2	1	1	2	2	1	3	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr19:37368294G>A	uc002oex.2	+	3	940	c.562G>A	c.(562-564)GCC>ACC	p.A188T	ZNF345_uc002oey.3_Missense_Mutation_p.A188T|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	188	C2H2-type 5.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTTGAATCAGCCCTTATTCG	0.413													22	41					0	0	0	0	A	37368294	A	A	37368294	3	1	207	1	0	0	0	0	1	0	0	0	17926	971	34	4	564	4	ZNF345	19	37368294	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	18255846	37368294	21760689	160	37887											
HNRNPL	3191	broad.mit.edu	37	chr19	39336360	39336360	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agggccacaaggattacagaTagtgtaaagaacatcctgca	16	7	10	8	0	0	2	0	0	0	2	1	3	1	3	2	2	3	2	2	2	6	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr19:39336360T>C	uc010xul.1	-	4	651	c.640A>G	c.(640-642)ATC>GTC	p.I214V	HNRNPL_uc010xum.1_Missense_Mutation_p.I81V|HNRNPL_uc010xun.1_5'Flank	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	214	RRM 2.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			GGATTACAGATAGTGTAAAGA	0.478													13	44					0	0	0	0	C	39336360	C	C	39336360	3	2	207	1	0	0	0	0	1	0	0	0	7309	1406	49	5	1169	5	HNRNPL	19	39336360	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	1968066	39336360	19792623	161	37888											
ZNF222	7673	broad.mit.edu	37	chr19	44536636	44536636	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagagcttctgtcttaggtCaagtcttaataggcattgca	11	14	9	7	0	4	1	1	0	3	1	4	1	4	1	0	2	2	3	0	2	5	6			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr19:44536636C>A	uc002oyc.2	+	4	992	c.809C>A	c.(808-810)TCA>TAA	p.S270*	ZNF284_uc010ejd.2_Intron|ZNF222_uc002oye.2_Nonsense_Mutation_p.S310*|ZNF222_uc002oyd.2_Nonsense_Mutation_p.S216*	NM_013360	NP_037492	Q9UK12	ZN222_HUMAN	zinc finger protein 222 isoform 2	270	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Prostate(69;0.0435)				TGTCTTAGGTCAAGTCTTAAT	0.393													34	97					9.04072e-19	1.01495e-18	1	0	A	44536636	A	A	44536636	4	1	207	1	0	0	0	0	0	1	0	0	17843	838	29	2	962	2	ZNF222	19	44536636	Nonsense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	5200276	44536636	14592347	162	37889											
HIF3A	64344	broad.mit.edu	37	chr19	46828852	46828852	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcacagactcttcacctccGggaaagacactgaggcagtg	11	7	11	12	1	2	3	1	1	1	2	3	4	3	4	2	2	1	2	2	2	1	1	rs139513428		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr19:46828852G>A	uc002peh.2	+	11	1425	c.1396G>A	c.(1396-1398)GGG>AGG	p.G466R	HIF3A_uc002peg.3_Missense_Mutation_p.G466R|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Missense_Mutation_p.G410R|HIF3A_uc002pej.1_Missense_Mutation_p.G397R|HIF3A_uc002pek.2_Missense_Mutation_p.G410R|HIF3A_uc010xxy.1_Missense_Mutation_p.G397R|HIF3A_uc002pel.2_Missense_Mutation_p.G464R|HIF3A_uc010xxz.1_Missense_Mutation_p.G415R	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	466	NTAD.|ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity	p.G464R(1)		upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CTTCACCTCCGGGAAAGACAC	0.507													45	129					0	0	0	0	A	46828852	A	A	46828852	3	1	207	1	0	0	0	0	1	0	0	0	7144	1116	39	1	1462	1	HIF3A	19	46828852	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	2292216	46828852	12300131	163	37890											
EMP3	2014	broad.mit.edu	37	chr19	48830823	48830823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtccctgaatctctggtacGactgcacgtggaacaacgac	11	8	10	12	3	1	1	0	1	1	0	3	4	2	2	1	2	4	2	1	2	4	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr19:48830823G>A	uc002piv.2	+	3	378	c.124G>A	c.(124-126)GAC>AAC	p.D42N		NM_001425	NP_001416	P54852	EMP3_HUMAN	epithelial membrane protein 3	42					cell growth|negative regulation of cell proliferation	integral to membrane					0		all_epithelial(76;6.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.00989)|Prostate(7;0.0143)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		TCTCTGGTACGACTGCACGTG	0.562													7	32					0	0	0	0	A	48830823	A	A	48830823	3	1	207	1	0	0	0	0	1	0	0	0	5127	1058	37	1	130	1	EMP3	19	48830823	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	2001971	48830823	10298160	164	37891											
SLC6A16	28968	broad.mit.edu	37	chr19	49813315	49813315	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaaagccactagagttcaTcgttaagggacatttctccc	12	10	7	12	1	2	1	1	0	1	1	4	2	2	2	3	1	1	2	3	1	3	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr19:49813315T>A	uc002pmz.2	-	4	916	c.682A>T	c.(682-684)ATG>TTG	p.M228L	SLC6A16_uc002pna.2_Missense_Mutation_p.M228L|hsa-mir-4324|MI0015854_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	228	Extracellular (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		CTAGAGTTCATCGTTAAGGGA	0.289													28	61					0	0	0	0	A	49813315	A	A	49813315	3	1	207	1	0	0	0	0	1	0	0	0	14743	1435	50	5	1564	5	SLC6A16	19	49813315	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	982492	49813315	9315668	165	37892											
ZNF616	90317	broad.mit.edu	37	chr19	52619980	52619980	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcagttcagccagacgtGactcaaagtttgatgtaagc	11	11	10	9	1	3	3	2	2	1	1	3	3	3	3	1	0	3	4	1	0	2	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr19:52619980G>T	uc002pym.2	-	4	720	c.437C>A	c.(436-438)TCA>TAA	p.S146*	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		AGCCAGACGTGACTCAAAGTT	0.383													35	122					9.04072e-19	1.01495e-18	1	0	T	52619980	T	T	52619980	4	4	207	1	0	0	0	0	0	1	0	0	18108	1294	45	2	1912	2	ZNF616	19	52619980	Nonsense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	2806665	52619980	6509003	166	37893											
NLRP4	147945	broad.mit.edu	37	chr19	56388492	56388492	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggtgtgcagctgttgtgtCgggctctgacgcatacggat	5	12	16	8	3	1	1	0	1	1	0	2	2	1	2	0	3	3	5	0	3	1	2	rs147716168		TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr19:56388492C>T	uc002qmd.3	+	8	3078	c.2656C>T	c.(2656-2658)CGG>TGG	p.R886W	NLRP4_uc002qmf.2_Missense_Mutation_p.R811W|NLRP4_uc010etf.2_Missense_Mutation_p.R661W	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	886	LRR 6.						ATP binding	p.R886W(1)		ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GCTGTTGTGTCGGGCTCTGAC	0.498													38	108					0	0	0	0	T	56388492	T	T	56388492	3	4	207	1	0	0	0	0	1	0	0	0	10533	875	31	1	2682	1	NLRP4	19	56388492	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	3768512	56388492	2740491	167	37894											
PEG3	5178	broad.mit.edu	37	chr19	57325894	57325894	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgtactcatagggctcatTcttatgaacagttacgtgat	10	13	8	10	2	3	2	2	2	1	0	3	2	3	2	1	1	3	3	1	1	5	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr19:57325894T>G	uc002qnu.2	-	7	4267	c.3916A>C	c.(3916-3918)AAT>CAT	p.N1306H	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.N1277H|PEG3_uc002qnv.2_Missense_Mutation_p.N1306H|PEG3_uc002qnw.2_Missense_Mutation_p.N1182H|PEG3_uc002qnx.2_Missense_Mutation_p.N1180H|PEG3_uc010etr.2_Missense_Mutation_p.N1306H	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1306					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.N1306H(2)		ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TAGGGCTCATTCTTATGAACA	0.448													18	52					0	0	0	0	G	57325894	G	G	57325894	3	3	207	1	0	0	0	0	1	0	0	0	11774	1783	62	5	854	5	PEG3	19	57325894	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	937402	57325894	1803089	168	37895											
VPS16	64601	broad.mit.edu	37	chr20	2844895	2844895	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgaagaggagcaaactggCactaagcaaggccatcgaga	16	4	13	8	1	0	3	0	1	0	2	1	6	0	4	1	3	3	3	1	3	4	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr20:2844895C>T	uc002whe.2	+	17	1730	c.1682C>T	c.(1681-1683)GCA>GTA	p.A561V	VPS16_uc002whh.2_RNA|PTPRA_uc002whj.2_5'UTR|VPS16_uc002whf.2_Missense_Mutation_p.A417V|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Missense_Mutation_p.A247V|VPS16_uc002whi.2_Missense_Mutation_p.A45V	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	561					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						AGCAAACTGGCACTAAGCAAG	0.602													14	41					0	0	0	0	T	2844895	T	T	2844895	3	4	207	1	0	0	0	0	1	0	0	0	17261	710	25	4	1748	4	VPS16	20	2844895	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08		2844895	60180625	169	37896											
CABIN1	23523	broad.mit.edu	37	chr22	24432587	24432587	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accattgaggatgatcatgaAggaagctttaaaagtcacaa	17	9	9	6	0	2	3	2	3	0	0	2	5	2	5	1	2	1	1	1	2	5	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr22:24432587A>G	uc002zzi.1	+	3	181	c.54A>G	c.(52-54)GAA>GAG	p.E18E	CABIN1_uc002zzj.1_Silent_p.E18E|CABIN1_uc002zzl.1_Silent_p.E18E|CABIN1_uc010guk.1_Silent_p.E18E|CABIN1_uc002zzk.1_Silent_p.E18E	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	18					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ATGATCATGAAGGAAGCTTTA	0.453													76	174					0	0	0	0	G	24432587	G	G	24432587	2	3	207	1	0	0	0	0	0	0	0	1	2540	69	3	5		5	CABIN1	22	24432587	Silent	SNP	A	TCGA-CV-6952-01A-11D-1912-08		24432587	26871979	170	37897											
DNAJB7	150353	broad.mit.edu	37	chr22	41257490	41257490	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaagccagggaagagaaaGaagtaaggccttcatgcccc	16	4	11	10	0	1	2	1	0	0	2	1	4	1	3	4	2	2	1	4	2	6	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr22:41257490G>C	uc003azj.2	-	1	641	c.509C>G	c.(508-510)TCT>TGT	p.S170C	XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azh.2_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_5'Flank|XPNPEP3_uc003azg.1_Intron|XPNPEP3_uc003azf.1_Intron|XPNPEP3_uc010gyh.1_5'Flank	NM_145174	NP_660157	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	170					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)	1						GGAAGAGAAAGAAGTAAGGCC	0.353													14	58					0	0	0	0	C	41257490	C	C	41257490	3	2	207	1	0	0	0	0	1	0	0	0	4647	942	33	2	424	2	DNAJB7	22	41257490	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	16824903	41257490	10047076	171	37898											
KIAA1644	85352	broad.mit.edu	37	chr22	44681438	44681438	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggggcccgctgacccggccGaggggcccgagcggggttcc	3	4	19	15	5	0	1	0	1	0	0	1	3	1	1	5	7	1	2	5	7	0	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr22:44681438G>A	uc003bet.2	-	4	602	c.469C>T	c.(469-471)CGG>TGG	p.R157W		NM_001099294	NP_001092764	Q3SXP7	K1644_HUMAN	hypothetical protein LOC85352 precursor	157	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				TGACCCGGCCGAGGGGCCCGA	0.697													21	67					0	0	0	0	A	44681438	A	A	44681438	3	1	207	1	0	0	0	0	1	0	0	0	8289	1057	37	1	138	1	KIAA1644	22	44681438	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	3423948	44681438	6623128	172	37899											
PKDREJ	10343	broad.mit.edu	37	chr22	46658432	46658432	+	Missense_Mutation	SNP	G	A	A																															cctgacccacggcgggcacgGagaacacctgccagtactgg																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr22:46658432G>A	uc003bhh.2	-	1	788	c.788C>T	c.(787-789)TCC>TTC	p.S263F		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	263	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GGCGGGCACGGAGAACACCTG	0.667													9	63					0	0	0	0	A	46658432	A	A	46658432	3	1	207	1	0	0	0	0	1	0	0	0	12025	1174	41	2	5977	2	PKDREJ	22	46658432	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	1976994	46658432	4646134	173	37900	71	2									
PKDREJ	10343	broad.mit.edu	37	chr22	46658434	46658434	+	Silent	SNP	G	A	A																															tgacccacggcgggcacggaGaacacctgccagtactgggc																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chr22:46658434G>A	uc003bhh.2	-	1	786	c.786C>T	c.(784-786)TTC>TTT	p.F262F		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	262	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CGGGCACGGAGAACACCTGCC	0.677													9	60					0	0	0	0	A	46658434	A	A	46658434	2	1	207	1	0	0	0	0	0	0	0	1	12025	933	33	2		2	PKDREJ	22	46658434	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	2	46658434	4646132	174	37901	71	2									
NLGN4X	57502	broad.mit.edu	37	chrX	6069124	6069124	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaagtatccaaattggcggtAaaccagatgggcagcatgtc	14	8	11	8	1	0	1	0	0	0	1	2	1	1	1	2	3	2	4	2	3	5	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:6069124A>C	uc010ndh.2	-	2	885	c.384T>G	c.(382-384)TTT>TTG	p.F128L	NLGN4X_uc004crp.2_Missense_Mutation_p.F128L|NLGN4X_uc004crq.2_Missense_Mutation_p.F128L|NLGN4X_uc010ndi.2_Missense_Mutation_p.F128L|NLGN4X_uc004crr.2_Missense_Mutation_p.F128L|NLGN4X_uc010ndj.2_Missense_Mutation_p.F128L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	128	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						AATTGGCGGTAAACCAGATGG	0.478													25	90					0	0	0	0	C	6069124	C	C	6069124	3	2	207	1	0	0	0	0	1	0	0	0	10518	359	13	5	2086	5	NLGN4X	23	6069124	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08		6069124	149201436	175	37902											
TBL1X	6907	broad.mit.edu	37	chrX	9652149	9652149	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtccaacatcaatgggaCgctagtgccaccggccgccc	9	5	10	17	3	1	0	1	0	0	0	2	1	2	1	6	2	2	1	6	2	3	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:9652149C>T	uc010ndq.2	+	6	646	c.278C>T	c.(277-279)ACG>ATG	p.T93M	TBL1X_uc004csq.3_Missense_Mutation_p.T42M|TBL1X_uc010ndr.2_Missense_Mutation_p.T42M|TBL1X_uc004csr.2_Missense_Mutation_p.T93M|TBL1X_uc004css.2_Missense_Mutation_p.T44M	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	93	F-box-like.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				ATCAATGGGACGCTAGTGCCA	0.567													16	60					0	0	0	0	T	9652149	T	T	9652149	3	4	207	1	0	0	0	0	1	0	0	0	15705	536	19	1	288	1	TBL1X	23	9652149	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	3583025	9652149	145618411	176	37903											
OFD1	8481	broad.mit.edu	37	chrX	13769430	13769430	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcacttaggagacaggagcAgaatataaagagttttgagg	15	8	14	4	0	0	4	0	1	0	3	0	6	0	5	0	4	1	3	0	4	5	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:13769430A>G	uc004cvp.3	+	10	1357	c.998A>G	c.(997-999)CAG>CGG	p.Q333R	OFD1_uc004cvr.3_5'UTR|OFD1_uc011mil.1_5'UTR|OFD1_uc004cvq.3_Missense_Mutation_p.Q193R|OFD1_uc010nen.2_Missense_Mutation_p.Q332R|OFD1_uc004cvs.3_Intron|OFD1_uc004cvu.3_Intron|OFD1_uc004cvv.3_Intron|OFD1_uc010neo.1_Intron	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	333	Potential.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						AGACAGGAGCAGAATATAAAG	0.303													24	48					0	0	0	0	G	13769430	G	G	13769430	3	3	207	1	0	0	0	0	1	0	0	0	10892	188	7	5	1036	5	OFD1	23	13769430	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	4117281	13769430	141501130	177	37904											
PRDX4	10549	broad.mit.edu	37	chrX	23700515	23700515	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cattcttctgttttacagagGtctcttcattattgatgaca	9	18	6	8	0	4	3	1	2	3	1	5	3	4	3	0	1	1	1	0	1	2	7			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:23700515G>A	uc004dam.2	+	5	645	c.602G>A	c.(601-603)GGT>GAT	p.G201D		NM_006406	NP_006397	Q13162	PRDX4_HUMAN	peroxiredoxin 4	201	Thioredoxin.				cell redox homeostasis|I-kappaB phosphorylation		thioredoxin peroxidase activity	p.G201D(1)		upper_aerodigestive_tract(1)	1						TTTTACAGAGGTCTCTTCATT	0.373													12	37					0	0	0	0	A	23700515	A	A	23700515	3	1	207	1	0	0	0	0	1	0	0	0	12529	1261	44	4	620	4	PRDX4	23	23700515	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	9931085	23700515	131570045	178	37905											
FAM47C	442444	broad.mit.edu	37	chrX	37027222	37027222	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agactggagtgtcccatctcCgcccagagcctcccaagact	9	7	9	16	1	1	3	0	0	1	3	4	4	3	4	5	1	1	0	5	1	1	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:37027222C>T	uc004ddl.1	+	1	753	c.739C>T	c.(739-741)CGC>TGC	p.R247C		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	247										ovary(3)	3						GTCCCATCTCCGCCCAGAGCC	0.627													18	66					0	0	0	0	T	37027222	T	T	37027222	3	4	207	1	0	0	0	0	1	0	0	0	5603	652	23	1	741	1	FAM47C	23	37027222	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	13326707	37027222	118243338	179	37906											
NDUFB11	54539	broad.mit.edu	37	chrX	47002066	47002066	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaggaccaggatgatggaGacgccaaagaagaagacaag	18	2	13	8	1	0	5	0	1	0	4	0	8	0	7	3	3	0	0	3	3	5	0			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:47002066G>A	uc004dhd.2	-	2	816	c.285C>T	c.(283-285)GTC>GTT	p.V95V	NDUFB11_uc004dhc.2_Silent_p.V95V|RBM10_uc004dhe.1_5'Flank|RBM10_uc004dhf.2_5'Flank|RBM10_uc004dhg.2_5'Flank|RBM10_uc004dhh.2_5'Flank|RBM10_uc010nhq.2_5'Flank|RBM10_uc004dhi.2_5'Flank	NM_001135998	NP_001129470	Q9NX14	NDUBB_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	95	Helical; (Potential).				respiratory electron transport chain|transport	integral to membrane|mitochondrial respiratory chain complex I					0						GGATGATGGAGACGCCAAAGA	0.537													27	61					0	0	0	0	A	47002066	A	A	47002066	2	1	207	1	0	0	0	0	0	0	0	1	10334	929	33	2		2	NDUFB11	23	47002066	Silent	SNP	G	TCGA-CV-6952-01A-11D-1912-08	9974844	47002066	108268494	180	37907											
HDAC6	10013	broad.mit.edu	37	chrX	48665100	48665100	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgagatccggaatggcAtggccatcattaggtaggac	10	8	15	8	1	1	1	1	1	0	1	2	4	2	3	2	6	0	3	2	6	3	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:48665100A>T	uc011mmi.1	+	8	714	c.619A>T	c.(619-621)ATG>TTG	p.M207L	HDAC6_uc004dks.1_Missense_Mutation_p.M207L|HDAC6_uc010nig.1_Missense_Mutation_p.M55L|HDAC6_uc004dkt.1_Missense_Mutation_p.M207L|HDAC6_uc004dku.3_3'UTR|HDAC6_uc011mmj.1_Missense_Mutation_p.M152L|HDAC6_uc011mmk.1_Missense_Mutation_p.M188L	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	207	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding	p.M207L(1)		ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	CCGGAATGGCATGGCCATCAT	0.473													13	31					0	0	0	0	T	48665100	T	T	48665100	3	4	207	1	0	0	0	0	1	0	0	0	7050	217	8	5	645	5	HDAC6	23	48665100	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	1663034	48665100	106605460	181	37908											
SSX7	280658	broad.mit.edu	37	chrX	52684344	52684345	+	5'Flank	INS	-	A	A																															ttctatatctgttgctactgINSaaaaaacagtccaaggccct																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:52684344_52684345insA	uc004dqx.1	-							NM_173358	NP_775494	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			skin(1)	1	Ovarian(276;0.236)					TGTTGCTACTGAAAAAACAGTC	0.421													---	---	---								A	52684345	A	A	52684344	6	5	207	0	1	1	1	0	0	0	0	0	15275	1305	45	0		0	SSX7	23	52684344	5'Flank	INS	-	TCGA-CV-6952-01A-11D-1912-08	4019244	52684344	102586216	182	37909											
HEPH	9843	broad.mit.edu	37	chrX	65392280	65392280	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctataaagaatacaaggatgActcatacacagatgaagtgg	18	8	9	6	0	1	4	1	2	0	2	1	5	1	5	0	2	2	0	0	2	8	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:65392280A>T	uc011moz.1	+	3	320	c.260A>T	c.(259-261)GAC>GTC	p.D87V	HEPH_uc004dwn.2_Missense_Mutation_p.D87V|HEPH_uc004dwo.2_5'UTR|HEPH_uc010nkr.2_Missense_Mutation_p.D87V|HEPH_uc011mpa.1_Missense_Mutation_p.D87V	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	84	Extracellular (Potential).|Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						TACAAGGATGACTCATACACA	0.478													13	41					0	0	0	0	T	65392280	T	T	65392280	3	4	207	1	0	0	0	0	1	0	0	0	7093	275	10	5	423	5	HEPH	23	65392280	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	12707936	65392280	89878280	183	37910											
HEPH	9843	broad.mit.edu	37	chrX	65393633	65393633	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaattgggcctctcatcacCtgtaaaagaggtacaggtcc	11	10	9	11	0	2	1	2	0	1	1	4	1	3	1	3	3	1	2	3	3	4	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:65393633C>T	uc011moz.1	+	4	684	c.624C>T	c.(622-624)ACC>ACT	p.T208T	HEPH_uc004dwn.2_Silent_p.T208T|HEPH_uc004dwo.2_5'UTR|HEPH_uc010nkr.2_Silent_p.T208T|HEPH_uc011mpa.1_Silent_p.T208T	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	205	Extracellular (Potential).|Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						CTCTCATCACCTGTAAAAGAG	0.498													5	13					0	0	0	0	T	65393633	T	T	65393633	2	4	207	1	0	0	0	0	0	0	0	1	7093	668	24	4		4	HEPH	23	65393633	Silent	SNP	C	TCGA-CV-6952-01A-11D-1912-08	1353	65393633	89876927	184	37911											
TAF1	6872	broad.mit.edu	37	chrX	70612527	70612527	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccacggggtgtggtgaaggaTtctcctatgtgaagattcca	9	11	13	8	1	1	3	0	2	1	1	3	4	2	4	3	4	0	0	3	4	3	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:70612527T>A	uc004dzu.3	+	19	2938	c.2887T>A	c.(2887-2889)TTC>ATC	p.F963I	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.F984I|TAF1_uc004dzv.3_Missense_Mutation_p.F137I	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	963					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				TGGTGAAGGATTCTCCTATGT	0.488													17	78					0	0	0	0	A	70612527	A	A	70612527	3	1	207	1	0	0	0	0	1	0	0	0	15579	1493	52	5	3024	5	TAF1	23	70612527	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	5218894	70612527	84658033	185	37912											
GPR174	84636	broad.mit.edu	37	chrX	78427029	78427029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tttgtggatcttcctaccagGaatgtcaacctggcccagtc	8	12	9	12	0	2	0	1	0	1	0	4	2	3	2	4	3	2	0	4	3	3	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:78427029G>C	uc004edg.1	+	1	561	c.525G>C	c.(523-525)AGG>AGC	p.R175S		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	175	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						TTCCTACCAGGAATGTCAACC	0.483										HNSCC(63;0.18)			19	64					0	0	0	0	C	78427029	C	C	78427029	3	2	207	1	0	0	0	0	1	0	0	0	6710	1165	41	2	527	2	GPR174	23	78427029	Missense_Mutation	SNP	G	TCGA-CV-6952-01A-11D-1912-08	7814502	78427029	76843531	186	37913											
TBX22	50945	broad.mit.edu	37	chrX	79283536	79283536	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctacccatggaggccttctTtcactctcgattttaaaacc	9	13	5	14	1	3	0	1	0	2	0	4	2	3	1	4	2	2	0	4	2	3	5			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:79283536T>C	uc010nmg.1	+	8	1044	c.910T>C	c.(910-912)TTC>CTC	p.F304L	TBX22_uc004edi.1_Missense_Mutation_p.F184L|TBX22_uc004edj.1_Missense_Mutation_p.F304L	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	304					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						GAGGCCTTCTTTCACTCTCGA	0.368													13	56					0	0	0	0	C	79283536	C	C	79283536	3	2	207	1	0	0	0	0	1	0	0	0	15724	1841	64	5	936	5	TBX22	23	79283536	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	856507	79283536	75987024	187	37914											
HDX	139324	broad.mit.edu	37	chrX	83724401	83724401	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatgaactggctggactgtaTataccagttacaatgacatc	13	11	9	8	0	0	2	0	2	0	0	1	4	0	3	1	2	3	3	1	2	6	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:83724401T>C	uc004eek.1	-	3	439	c.330A>G	c.(328-330)ATA>ATG	p.I110M	HDX_uc011mqv.1_Missense_Mutation_p.I110M|HDX_uc004eel.1_Missense_Mutation_p.I52M	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	110						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.I110M(1)		upper_aerodigestive_tract(1)|ovary(1)	2						CTGGACTGTATATACCAGTTA	0.408													28	89					0	0	0	0	C	83724401	C	C	83724401	3	2	207	1	0	0	0	0	1	0	0	0	7065	1396	49	5	1774	5	HDX	23	83724401	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	4440865	83724401	71546159	188	37915											
TCEAL7	56849	broad.mit.edu	37	chrX	102586386	102586386	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagtgcagcgtgccaaagAgggaggaaaaacgcccgtat	15	4	13	9	3	0	1	0	0	0	1	0	3	0	3	2	2	4	2	2	2	5	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:102586386A>T	uc004ekc.1	+	3	268	c.55A>T	c.(55-57)AGG>TGG	p.R19W		NM_152278	NP_689491	Q9BRU2	TCAL7_HUMAN	transcription elongation factor A (SII)-like 7	19					negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.R19W(1)		upper_aerodigestive_tract(1)	1						cgtgccaaagagggaggaaaa	0.05													3	8					0	0	0	0	T	102586386	T	T	102586386	3	4	207	1	0	0	0	0	1	0	0	0	15742	295	11	5	57	5	TCEAL7	23	102586386	Missense_Mutation	SNP	A	TCGA-CV-6952-01A-11D-1912-08	18861985	102586386	52684174	189	37916											
VSIG1	340547	broad.mit.edu	37	chrX	107301344	107301344	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatctaatgtcactctcatCtgcatctacaccaccactgt	10	12	5	14	0	5	0	2	0	4	0	6	1	5	1	2	1	2	1	2	1	2	2			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:107301344C>G	uc004eno.2	+	2	287	c.126C>G	c.(124-126)ATC>ATG	p.I42M	VSIG1_uc011msk.1_Missense_Mutation_p.I42M	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	42	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane		p.I42M(2)		upper_aerodigestive_tract(1)|ovary(1)	2						TCACTCTCATCTGCATCTACA	0.448													19	56					0	0	0	0	G	107301344	G	G	107301344	3	3	207	1	0	0	0	0	1	0	0	0	17290	903	32	2	132	2	VSIG1	23	107301344	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	4714958	107301344	47969216	190	37917											
IL13RA2	3598	broad.mit.edu	37	chrX	114238663	114238663	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatgtatcacagaaaaattCtggaatctagaaagaactct	17	11	6	7	0	5	3	2	0	3	3	5	4	5	4	0	1	1	1	0	1	7	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:114238663C>T	uc004epx.2	-	10	1248	c.1123G>A	c.(1123-1125)GAA>AAA	p.E375K		NM_000640	NP_000631	Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2 precursor	375	Cytoplasmic (Potential).					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity	p.E375K(1)		upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3						CAGAAAAATTCTGGAATCTAG	0.333													6	16					0	0	0	0	T	114238663	T	T	114238663	3	4	207	1	0	0	0	0	1	0	0	0	7669	922	32	2	23	2	IL13RA2	23	114238663	Missense_Mutation	SNP	C	TCGA-CV-6952-01A-11D-1912-08	6937319	114238663	41031897	191	37918											
IGSF1	3547	broad.mit.edu	37	chrX	130415220	130415220	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagtctccgacacttccaccTtatccacagcactaccaaca	12	8	4	17	1	1	0	0	0	1	0	4	2	3	0	5	0	3	1	5	0	3	3			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:130415220T>G	uc004ewd.2	-	9	1856	c.1618A>C	c.(1618-1620)AGG>CGG	p.R540R	IGSF1_uc004ewe.3_Silent_p.R529R|IGSF1_uc004ewf.2_Silent_p.R520R	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	540	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CACTTCCACCTTATCCACAGC	0.493													78	215					0	0	0	0	G	130415220	G	G	130415220	2	3	207	1	0	0	0	0	0	0	0	1	7635	1608	56	5		5	IGSF1	23	130415220	Silent	SNP	T	TCGA-CV-6952-01A-11D-1912-08	16176557	130415220	24855340	192	37919											
SLC9A6	10479	broad.mit.edu	37	chrX	135098865	135098865	+	Frame_Shift_Del	DEL	T	-	-																															ctcctacatggggctgacacTgttcaccttccagaaccatg																										TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:135098865delT	uc004ezj.2	+	10	1278	c.1202delT	c.(1201-1203)CTGfs	p.L401fs	SLC9A6_uc004ezk.2_Frame_Shift_Del_p.L433fs	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	401	Helical; (Potential).				regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GGGCTGACACTGTTCACCTTC	0.333													---	---	---								-	135098865	-	-	135098865	7	5	207	1	0	1	0	1	0	0	0	0	14782	1580	55	0	1336	0	SLC9A6	23	135098865	Frame_Shift_Del	DEL	T	TCGA-CV-6952-01A-11D-1912-08	4683645	135098865	20171695	193	37920											
MCF2	4168	broad.mit.edu	37	chrX	138686866	138686866	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggaaacaaggtcccactcTttctggagcatgagcacaat	13	8	9	11	0	2	1	0	1	2	0	3	3	3	3	1	3	3	2	1	3	3	1			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:138686866T>A	uc004fau.2	-	15	2011	c.1717A>T	c.(1717-1719)AGA>TGA	p.R573*	MCF2_uc004fav.2_Nonsense_Mutation_p.R589*|MCF2_uc011mwl.1_Nonsense_Mutation_p.R550*|MCF2_uc010nsh.1_Nonsense_Mutation_p.R573*|MCF2_uc011mwm.1_Nonsense_Mutation_p.R534*|MCF2_uc011mwn.1_Nonsense_Mutation_p.R718*|MCF2_uc004faw.2_Nonsense_Mutation_p.R633*|MCF2_uc011mwo.1_Nonsense_Mutation_p.R649*	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	573	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					GGTCCCACTCTTTCTGGAGCA	0.308													8	14					0	0	0	0	A	138686866	A	A	138686866	4	1	207	1	0	0	0	0	0	1	0	0	9431	1617	56	5	1132	5	MCF2	23	138686866	Nonsense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	3588001	138686866	16583694	194	37921											
HCFC1	3054	broad.mit.edu	37	chrX	153227686	153227686	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttacttatttccgatggTggttgccgagtggagactgc	7	13	12	9	2	0	1	0	0	0	1	1	4	1	1	2	3	3	1	2	3	2	4			TCGA-CV-6952-01A-11D-1912-08	TCGA-CV-6952-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d859062-3655-471e-b3dd-e6ff0671c076	6146d8e5-9bb7-47ef-b2e6-c4d9cd4a4cab	g.chrX:153227686T>C	uc004fjp.2	-	5	1312	c.784A>G	c.(784-786)ACC>GCC	p.T262A		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	262	Kelch 4.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCGATGGTGGTTGCCGAG	0.587													3	30					0	0	0	0	C	153227686	C	C	153227686	3	2	207	1	0	0	0	0	1	0	0	0	7030	1696	59	5	5411	5	HCFC1	23	153227686	Missense_Mutation	SNP	T	TCGA-CV-6952-01A-11D-1912-08	14540820	153227686	2042874	195	37922											
GNB1	2782	broad.mit.edu	37	chr1	1720641	1720641	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgagctcctggtcagcaCgaaggtcaaacagcctgcag	11	7	11	12	1	3	1	3	1	0	0	4	2	4	1	2	2	5	3	2	2	2	0	rs11554059		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:1720641C>T	uc001aif.2	-	10	1099	c.767G>A	c.(766-768)CGT>CAT	p.R256H	GNB1_uc009vky.2_Missense_Mutation_p.R156H	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	256					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		CTGGTCAGCACGAAGGTCAAA	0.522											OREG0012998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	30					0	0	0	0	T	1720641	T	T	1720641	3	4	208	1	0	0	0	0	1	0	0	0	6552	536	19	1	263	1	GNB1	1	1720641	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08		1720641	247529980	1	37923											
AIM1L	55057	broad.mit.edu	37	chr1	26672763	26672763	+	5'Flank	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacacatgggggctcagtcCtgggagcttggcggctgcca	6	7	15	13	1	1	0	1	0	0	0	2	1	2	1	3	5	2	3	3	5	0	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:26672763C>A	uc001bmd.3	-						uc009vsi.1_Missense_Mutation_p.R129M	NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like								sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		GGGCTCAGTCCTGGGAGCTTG	0.602													9	39					0.000673444	0.00449117	1	0	A	26672763	A	A	26672763	1	1	208	0	1	0	0	0	0	0	0	0	431	696	24	4		4	AIM1L	1	26672763	5'Flank	SNP	C	TCGA-CV-6953-01A-11D-1912-08	24952122	26672763	222577858	2	37924											
SPOCD1	90853	broad.mit.edu	37	chr1	32280968	32280968	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggccaaaagcacaacaCgggccctgtgtggagacaga	12	4	13	12	1	0	2	0	0	0	2	0	3	0	2	3	3	2	1	3	3	3	0			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:32280968C>T	uc001bts.1	-	2	25	c.-33G>A	c.(-35--31)CCGTG>CCATG		SPOCD1_uc001btu.2_Translation_Start_Site|SPOCD1_uc001btv.2_Intron	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1						transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		AAGCACAACACGGGCCCTGTG	0.602													11	27					0	0	0	0	T	32280968	T	T	32280968	1	4	208	1	0	0	0	0	0	0	0	0	15144	551	19	1		1	SPOCD1	1	32280968	Translation_Start_Site	SNP	C	TCGA-CV-6953-01A-11D-1912-08	5608205	32280968	216969653	3	37925											
GRIK3	2899	broad.mit.edu	37	chr1	37271718	37271718	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgctcacccatgggcgtgccGatgccgtagcccttggagtc	5	8	13	15	4	1	0	1	0	0	0	2	2	1	1	4	2	3	2	4	2	1	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:37271718G>A	uc001caz.2	-	14	2436	c.2301C>T	c.(2299-2301)ATC>ATT	p.I767I	GRIK3_uc001cba.1_Silent_p.I767I	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	767	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGGGCGTGCCGATGCCGTAGC	0.662													13	53					0	0	0	0	A	37271718	A	A	37271718	2	1	208	1	0	0	0	0	0	0	0	1	6814	1048	37	1		1	GRIK3	1	37271718	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	4990750	37271718	211978903	4	37926											
C1orf109	54955	broad.mit.edu	37	chr1	38152075	38152075	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctcatagatctgaaacaCtcgctccacatggctgctga	10	11	8	12	1	2	3	1	2	1	1	4	3	3	3	1	1	3	4	1	1	2	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:38152075C>T	uc001cbp.2	-	3	515	c.325G>A	c.(325-327)GTG>ATG	p.V109M	C1orf109_uc001cbn.2_5'Flank|C1orf109_uc010oig.1_Missense_Mutation_p.V172M|C1orf109_uc001cbo.2_Missense_Mutation_p.V171M|C1orf109_uc001cbq.1_Silent_p.E91E	NM_017850	NP_060320	Q9NX04	CA109_HUMAN	hypothetical protein LOC54955	109											0		Myeloproliferative disorder(586;0.0393)				ATCTGAAACACTCGCTCCACA	0.498													5	38					0	0	0	0	T	38152075	T	T	38152075	3	4	208	1	0	0	0	0	1	0	0	0	1991	565	20	4	298	4	C1orf109	1	38152075	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	880357	38152075	211098546	5	37927											
GLIS1	148979	broad.mit.edu	37	chr1	54060170	54060170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgccttccggcaggcttcaaGttgcaagctgccctcatggc	6	9	11	15	2	2	0	2	0	0	0	3	0	3	0	3	3	3	5	3	3	2	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:54060170G>A	uc001cvr.1	-	3	973	c.406C>T	c.(406-408)CTT>TTT	p.L136F		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	136					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						CAGGCTTCAAGTTGCAAGCTG	0.667													12	42					0	0	0	0	A	54060170	A	A	54060170	3	1	208	1	0	0	0	0	1	0	0	0	6482	1029	36	4	1488	4	GLIS1	1	54060170	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	15908095	54060170	195190451	6	37928											
CTTNBP2NL	55917	broad.mit.edu	37	chr1	112999913	112999913	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atctgctaccactccattgaCcaaaactcattcccaggcag	12	9	5	15	0	2	1	1	1	1	0	4	1	4	1	4	1	3	2	4	1	3	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:112999913C>T	uc001ebx.2	+	6	2027	c.1799C>T	c.(1798-1800)ACC>ATC	p.T600I	CTTNBP2NL_uc001ebz.2_RNA	NM_018704	NP_061174	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	600						actin cytoskeleton	protein binding			central_nervous_system(2)|ovary(1)	3		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTCCATTGACCAAAACTCAT	0.522													10	79					0	0	0	0	T	112999913	T	T	112999913	3	4	208	1	0	0	0	0	1	0	0	0	4063	507	18	4	1813	4	CTTNBP2NL	1	112999913	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	58939743	112999913	136250708	7	37929											
AQP10	89872	broad.mit.edu	37	chr1	154295468	154295468	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atacttgaaggggcccacctGaatccagccttctccctggc	8	9	9	15	0	1	2	0	2	1	0	3	2	2	2	5	3	2	0	5	3	3	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:154295468G>A	uc001feu.2	+	3	283	c.243G>A	c.(241-243)CTG>CTA	p.L81L	AQP10_uc001fev.2_Silent_p.L81L|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	81	Cytoplasmic (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGGCCCACCTGAATCCAGCCT	0.363													25	74					0	0	0	0	A	154295468	A	A	154295468	2	1	208	1	0	0	0	0	0	0	0	1	822	1277	45	2		2	AQP10	1	154295468	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	41295555	154295468	94955153	8	37930											
LAMC1	3915	broad.mit.edu	37	chr1	183085957	183085957	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctcggggttgcacacccTgcttctgctttgggcattct	4	14	10	13	1	2	0	0	0	2	0	4	0	3	0	2	3	3	5	2	3	0	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:183085957T>A	uc001gpy.3	+	8	1740	c.1483T>A	c.(1483-1485)TGC>AGC	p.C495S		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	495	Laminin EGF-like 5; first part.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTGCACACCCTGCTTCTGCTT	0.388													18	73					0	0	0	0	A	183085957	A	A	183085957	3	1	208	1	0	0	0	0	1	0	0	0	8654	1580	55	5	1513	5	LAMC1	1	183085957	Missense_Mutation	SNP	T	TCGA-CV-6953-01A-11D-1912-08	28790489	183085957	66164664	9	37931											
RGS21	431704	broad.mit.edu	37	chr1	192335209	192335209	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttataaaaaactggtaaaTagccaacaggttccaaatca	19	10	5	7	0	1	0	1	0	0	0	2	0	2	0	2	2	3	2	2	2	9	6			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:192335209T>C	uc001gsh.2	+	5	588	c.414T>C	c.(412-414)AAT>AAC	p.N138N		NM_001039152	NP_001034241	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	138					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2						AACTGGTAAATAGCCAACAGG	0.333													13	46					0	0	0	0	C	192335209	C	C	192335209	2	2	208	1	0	0	0	0	0	0	0	1	13369	1403	49	5		5	RGS21	1	192335209	Silent	SNP	T	TCGA-CV-6953-01A-11D-1912-08	9249252	192335209	56915412	10	37932											
RPS6KC1	26750	broad.mit.edu	37	chr1	213414331	213414331	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagattctggttcaagttcAgaagaagaatgtactactag	14	11	9	7	0	3	4	2	0	1	4	3	4	3	4	1	1	2	3	1	1	7	6			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr1:213414331A>C	uc010ptr.1	+	11	1671	c.1512A>C	c.(1510-1512)TCA>TCC	p.S504S	RPS6KC1_uc001hkd.2_Silent_p.S492S|RPS6KC1_uc010pts.1_Silent_p.S292S|RPS6KC1_uc010ptt.1_Silent_p.S292S|RPS6KC1_uc010ptu.1_Silent_p.S323S|RPS6KC1_uc010ptv.1_Silent_p.S39S|RPS6KC1_uc001hke.2_Silent_p.S323S	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	504					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		GTTCAAGTTCAGAAGAAGAAT	0.408													15	35					0	0	0	0	C	213414331	C	C	213414331	2	2	208	1	0	0	0	0	0	0	0	1	13723	175	7	5		5	RPS6KC1	1	213414331	Silent	SNP	A	TCGA-CV-6953-01A-11D-1912-08	21079122	213414331	35836290	11	37933											
ALLC	55821	broad.mit.edu	37	chr2	3726069	3726069	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccctagagtgacagcccGtgcttcaaagagcatgaata	12	9	10	10	1	1	4	1	2	0	2	1	4	1	4	2	0	4	2	2	0	4	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:3726069G>A	uc010ewt.2	+	4	257	c.96G>A	c.(94-96)CCG>CCA	p.P32P		NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	51							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		GTGACAGCCCGTGCTTCAAAG	0.488										HNSCC(21;0.051)			7	30					0	0	0	0	A	3726069	A	A	3726069	2	1	208	1	0	0	0	0	0	0	0	1	534	1132	40	1		1	ALLC	2	3726069	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08		3726069	239473304	12	37934											
PLEKHH2	130271	broad.mit.edu	37	chr2	43953472	43953472	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggttgacagatcttgtgAttcagatgaagattatgaag	14	12	12	3	0	2	8	1	4	1	4	2	8	2	8	0	1	0	1	0	1	3	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:43953472A>T	uc010yny.1	+	17	2686	c.2603A>T	c.(2602-2604)GAT>GTT	p.D868V	PLEKHH2_uc002rtf.3_Missense_Mutation_p.D867V	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	868	PH 2.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGATCTTGTGATTCAGATGAA	0.388													10	44					0	0	0	0	T	43953472	T	T	43953472	3	4	208	1	0	0	0	0	1	0	0	0	12132	333	12	5	2665	5	PLEKHH2	2	43953472	Missense_Mutation	SNP	A	TCGA-CV-6953-01A-11D-1912-08	40227403	43953472	199245901	13	37935											
GPR45	11250	broad.mit.edu	37	chr2	105858505	105858505	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcatcgtgtaccagaggccgGctatgcgctcggccatcaac	8	8	11	14	4	2	1	2	0	0	1	4	1	2	1	3	3	3	3	3	3	3	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:105858505G>T	uc002tco.1	+	1	306	c.190G>T	c.(190-192)GCT>TCT	p.A64S		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	64	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						CCAGAGGCCGGCTATGCGCTC	0.617													33	104					1.56442e-22	1.20063e-21	1	0	T	105858505	T	T	105858505	3	4	208	1	0	0	0	0	1	0	0	0	6734	1203	42	4	192	4	GPR45	2	105858505	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	61905033	105858505	137340868	14	37936											
OSGEPL1	64172	broad.mit.edu	37	chr2	190619979	190619982	+	Frame_Shift_Del	DEL	ACAG	-	-																															aactccttgaactaatgccaAcagacagtgacctccagaaa																										TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:190619979_190619982delACAG	uc002uqz.1	-	3	1060_1063	c.526_529delCTGT	c.(526-531)CTGTTGfs	p.L176fs	OSGEPL1_uc002ura.1_RNA|OSGEPL1_uc010zfy.1_Frame_Shift_Del_p.L176fs	NM_022353	NP_071748	Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	176_177					proteolysis|tRNA processing		metalloendopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			ACTAATGCCAACAGACAGTGACCT	0.368													---	---	---								-	190619982	-	-	190619979	7	5	208	1	0	1	0	1	0	0	0	0	11342	40	2	0	739	0	OSGEPL1	2	190619979	Frame_Shift_Del	DEL	ACAG	TCGA-CV-6953-01A-11D-1912-08	84761474	190619979	52579394	15	37937											
HECW2	57520	broad.mit.edu	37	chr2	197183717	197183717	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccaggtcactctctccctCaggcctggtgctggcttcgc	3	12	10	16	1	3	0	2	0	1	0	7	0	5	0	3	4	1	2	3	4	0	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:197183717C>T	uc002utm.1	-	9	2080	c.1897G>A	c.(1897-1899)GAG>AAG	p.E633K	HECW2_uc002utl.1_Missense_Mutation_p.E277K	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	633					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CTCTCTCCCTCAGGCCTGGTG	0.592													13	31					0	0	0	0	T	197183717	T	T	197183717	3	4	208	1	0	0	0	0	1	0	0	0	7082	835	29	2	2905	2	HECW2	2	197183717	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	6563738	197183717	46015656	16	37938											
CASP8	841	broad.mit.edu	37	chr2	202150039	202150039	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctgagagagcgatgtcctCggtaagttttgcctactcag	8	11	12	10	2	1	2	1	1	0	1	3	4	2	2	3	1	3	2	3	1	2	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:202150039C>T	uc002uxr.1	+	9	1512	c.1303C>T	c.(1303-1305)CGA>TGA	p.R435*	CASP8_uc002uxp.1_Nonsense_Mutation_p.R452*|CASP8_uc002uxq.1_Nonsense_Mutation_p.R420*|CASP8_uc002uxt.1_Nonsense_Mutation_p.R494*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.R420*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.R351*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	435					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GCGATGTCCTCGGTAAGTTTT	0.502										HNSCC(4;0.00038)			15	54					0	0	0	0	T	202150039	T	T	202150039	4	4	208	1	0	0	0	0	0	1	0	0	2689	898	31	1	1610	1	CASP8	2	202150039	Nonsense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	4966322	202150039	41049334	17	37939											
ZDBF2	57683	broad.mit.edu	37	chr2	207169470	207169470	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agatgagacacatgtgaataCtgggtcatcgtctgaagtgg	12	10	13	6	1	2	4	1	3	1	2	3	5	2	4	0	2	1	0	0	2	3	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:207169470C>A	uc002vbp.2	+	5	468	c.218C>A	c.(217-219)ACT>AAT	p.T73N		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	73							nucleic acid binding|zinc ion binding			ovary(3)	3						CATGTGAATACTGGGTCATCG	0.383													22	39					2.21704e-12	1.61193e-11	1	0	A	207169470	A	A	207169470	3	1	208	1	0	0	0	0	1	0	0	0	17666	565	20	4	228	4	ZDBF2	2	207169470	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	5019431	207169470	36029903	18	37940											
OBSL1	23363	broad.mit.edu	37	chr2	220419305	220419305	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcggtgacggtggccgtcCgagtggatgtgacacttggg	6	9	18	8	4	0	2	0	2	0	0	2	4	1	3	2	5	0	0	2	5	0	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:220419305C>T	uc010fwk.2	-	15	4824	c.4767G>A	c.(4765-4767)TCG>TCA	p.S1589S		NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1589					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GGTGGCCGTCCGAGTGGATGT	0.642													7	20					0	0	0	0	T	220419305	T	T	220419305	2	4	208	1	0	0	0	0	0	0	0	1	10867	639	23	1		1	OBSL1	2	220419305	Silent	SNP	C	TCGA-CV-6953-01A-11D-1912-08	13249835	220419305	22780068	19	37941											
THAP4	51078	broad.mit.edu	37	chr2	242573331	242573331	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtggaagatggatggcaCggccgtgggcttcagcaggc	8	6	18	9	2	1	1	1	0	0	1	1	3	1	3	1	7	1	3	1	7	1	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr2:242573331C>T	uc002wbt.2	-	2	464	c.241G>A	c.(241-243)GTG>ATG	p.V81M		NM_015963	NP_057047	Q8WY91	THAP4_HUMAN	THAP domain containing 4 isoform 1	81	THAP-type.						DNA binding|metal ion binding				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		ATGGATGGCACGGCCGTGGGC	0.587													36	123					0	0	0	0	T	242573331	T	T	242573331	3	4	208	1	0	0	0	0	1	0	0	0	15912	536	19	1	1520	1	THAP4	2	242573331	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	22154026	242573331	626042	20	37942											
FLNB	2317	broad.mit.edu	37	chr3	58120482	58120482	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagatgccggggaaggcctgCttgctgttcaaataacggta	10	9	14	8	2	1	1	1	0	0	1	1	3	1	2	2	4	4	4	2	4	4	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr3:58120482C>G	uc003djj.2	+	27	4819	c.4654C>G	c.(4654-4656)CTT>GTT	p.L1552V	FLNB_uc010hne.2_Missense_Mutation_p.L1583V|FLNB_uc003djk.2_Missense_Mutation_p.L1552V|FLNB_uc010hnf.2_Missense_Mutation_p.L1552V|FLNB_uc003djl.2_Missense_Mutation_p.L1383V|FLNB_uc003djm.2_Missense_Mutation_p.L1383V	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1552	Filamin 14.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGAAGGCCTGCTTGCTGTTCA	0.473													43	132					0	0	0	0	G	58120482	G	G	58120482	3	3	208	1	0	0	0	0	1	0	0	0	5966	797	28	4	4857	4	FLNB	3	58120482	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08		58120482	139901948	21	37943											
KIAA2018	205717	broad.mit.edu	37	chr3	113377777	113377777	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttatcctgagatgtctcttGttgtagattaggggtagaat	9	17	11	4	0	1	3	0	1	1	3	3	4	2	3	1	2	0	3	1	2	5	7			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr3:113377777G>A	uc003eam.2	-	7	3163	c.2752C>T	c.(2752-2754)CAA>TAA	p.Q918*	KIAA2018_uc003eal.2_Nonsense_Mutation_p.Q862*	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	918					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GATGTCTCTTGTTGTAGATTA	0.448													33	98					0	0	0	0	A	113377777	A	A	113377777	4	1	208	1	0	0	0	0	0	1	0	0	8307	1386	48	4	3989	4	KIAA2018	3	113377777	Nonsense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	55257295	113377777	84644653	22	37944											
EIF2B5	8893	broad.mit.edu	37	chr3	183858377	183858377	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagagctgcactcattccCggcacaacatctaccgaggg	10	6	9	16	2	2	1	1	0	1	1	3	2	3	1	3	2	4	3	3	2	2	2	rs113994068		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr3:183858377C>A	uc003fmp.2	+	7	1379	c.1015C>A	c.(1015-1017)CGG>AGG	p.R339R	EIF2B5_uc003fmq.2_Silent_p.R60R|EIF2B5_uc003fmr.2_5'Flank	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,	339			R -> Q (in VWM).|R -> W (in VWM).|R -> P (in VWM).		astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CACTCATTCCCGGCACAACAT	0.587													5	112					0.00116845	0.0076863	1	0	A	183858377	A	A	183858377	2	1	208	1	0	0	0	0	0	0	0	1	5026	643	23	3		3	EIF2B5	3	183858377	Silent	SNP	C	TCGA-CV-6953-01A-11D-1912-08	70480600	183858377	14164053	23	37945											
UGT2B10	7365	broad.mit.edu	37	chr4	69682402	69682402	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctttattttgacttttGgttccaaatatttaatatga	10	21	6	4	0	0	2	0	2	0	0	1	2	1	2	1	1	1	2	1	1	5	11			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr4:69682402G>C	uc003hee.2	+	1	690	c.665G>C	c.(664-666)TGG>TCG	p.W222S	UGT2B10_uc011cam.1_Intron	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	222					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TTTGACTTTTGGTTCCAAATA	0.313													17	65					0	0	0	0	C	69682402	C	C	69682402	3	2	208	1	0	0	0	0	1	0	0	0	17024	1357	47	4	667	4	UGT2B10	4	69682402	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08		69682402	121471874	24	37946											
FBXO8	26269	broad.mit.edu	37	chr4	175158632	175158632	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaaaatcttcactaatattTtgagcagcgcgacgggtatt	13	12	8	8	3	2	1	1	1	1	0	2	2	2	1	0	1	2	2	0	1	5	7	rs148818503		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr4:175158632T>A	uc003itp.2	-	6	1741	c.891A>T	c.(889-891)CAA>CAT	p.Q297H	FBXO8_uc003itq.2_Missense_Mutation_p.Q256H	NM_012180	NP_036312	Q9NRD0	FBX8_HUMAN	F-box only protein 8	297					regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(2)	2		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		CACTAATATTTTGAGCAGCGC	0.378													19	58					0	0	0	0	A	175158632	A	A	175158632	3	1	208	1	0	0	0	0	1	0	0	0	5793	1838	64	5	72	5	FBXO8	4	175158632	Missense_Mutation	SNP	T	TCGA-CV-6953-01A-11D-1912-08	105476230	175158632	15995644	25	37947											
IRF2	3660	broad.mit.edu	37	chr4	185339790	185339790	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cttcttcaatatcaggcaagGaattcatggcgcatctgaaa	13	11	8	9	1	5	1	3	1	2	0	5	2	5	2	0	3	0	2	0	3	5	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr4:185339790G>A	uc003iwf.3	-	4	460	c.260C>T	c.(259-261)TCC>TTC	p.S87F		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	87	IRF tryptophan pentad repeat.				blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		ATCAGGCAAGGAATTCATGGC	0.408													8	36					0	0	0	0	A	185339790	A	A	185339790	3	1	208	1	0	0	0	0	1	0	0	0	7867	1174	41	2	813	2	IRF2	4	185339790	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	10181158	185339790	5814486	26	37948											
CDH12	1010	broad.mit.edu	37	chr5	21817158	21817158	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtattcaatttctgcattttGtccaaaatcaggatccacag	12	14	6	9	0	3	0	2	0	1	0	5	1	5	1	2	1	1	2	2	1	4	5			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:21817158G>T	uc010iuc.2	-	6	1356	c.898C>A	c.(898-900)CAA>AAA	p.Q300K	CDH12_uc011cno.1_Missense_Mutation_p.Q260K|CDH12_uc003jgk.2_Missense_Mutation_p.Q300K	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	300	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TCTGCATTTTGTCCAAAATCA	0.388										HNSCC(59;0.17)			14	87					3.27435e-08	2.31117e-07	1	0	T	21817158	T	T	21817158	3	4	208	1	0	0	0	0	1	0	0	0	3113	1386	48	4	1514	4	CDH12	5	21817158	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08		21817158	159098102	27	37949											
TTC23L	153657	broad.mit.edu	37	chr5	34864544	34864544	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tttccttgactatttcactgGcagagaagcctatttcaacc	10	14	6	11	0	2	2	2	1	0	1	3	3	3	2	3	1	2	1	3	1	4	6			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:34864544G>A	uc003jiu.2	+	6	642	c.539G>A	c.(538-540)GGC>GAC	p.G180D	TTC23L_uc003jiv.2_5'UTR|TTC23L_uc010iut.1_5'UTR	NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	180	Potential.						binding			central_nervous_system(1)	1						TATTTCACTGGCAGAGAAGCC	0.423													6	105					0	0	0	0	A	34864544	A	A	34864544	3	1	208	1	0	0	0	0	1	0	0	0	16759	1203	42	4	557	4	TTC23L	5	34864544	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	13047386	34864544	146050716	28	37950											
PLK2	10769	broad.mit.edu	37	chr5	57751189	57751189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aataaattgctcaggagcatCtgttgctgggaaaactgagc	13	10	11	7	0	2	1	1	1	1	0	2	3	2	3	0	2	5	4	0	2	5	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:57751189C>T	uc003jrn.2	-	12	1805	c.1678G>A	c.(1678-1680)GAT>AAT	p.D560N		NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	560	POLO box 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		TCAGGAGCATCTGTTGCTGGG	0.408													15	67					0	0	0	0	T	57751189	T	T	57751189	3	4	208	1	0	0	0	0	1	0	0	0	12151	913	32	2	391	2	PLK2	5	57751189	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	22886645	57751189	123164071	29	37951											
TTC37	9652	broad.mit.edu	37	chr5	94833175	94833175	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagacaacagagaccaaagaGcagggtcaccagggttgcta	15	4	13	9	0	1	3	1	0	0	3	1	5	1	3	2	2	3	3	2	2	3	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:94833175G>T	uc003klb.2	-	34	3851	c.3581C>A	c.(3580-3582)GCT>GAT	p.A1194D		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1194							binding			ovary(3)|pancreas(1)	4						AGACCAAAGAGCAGGGTCACC	0.373													6	20					0.000157383	0.00106426	1	0	T	94833175	T	T	94833175	3	4	208	1	0	0	0	0	1	0	0	0	16773	971	34	4	1153	4	TTC37	5	94833175	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	37081986	94833175	86082085	30	37952											
FSTL4	23105	broad.mit.edu	37	chr5	132556521	132556521	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgacgatgataccgtcGtcggagaagacatagaacat	14	8	12	7	4	0	5	0	2	0	3	2	8	0	6	1	2	2	0	1	2	4	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:132556521G>A	uc003kyn.1	-	12	1595	c.1377C>T	c.(1375-1377)GAC>GAT	p.D459D	FSTL4_uc003kym.1_Silent_p.D108D	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	459						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGATACCGTCGTCGGAGAAGA	0.547													19	84					0	0	0	0	A	132556521	A	A	132556521	2	1	208	1	0	0	0	0	0	0	0	1	6113	1136	40	1		1	FSTL4	5	132556521	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	37723346	132556521	48358739	31	37953											
PCDHGB5	56101	broad.mit.edu	37	chr5	140779287	140779287	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaactcacactacaggcccgCgaccagggctcgcctgcgct	8	5	11	17	4	1	0	1	0	0	0	2	2	1	0	3	2	3	2	3	2	2	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:140779287C>T	uc003lkf.1	+	1	1593	c.1593C>T	c.(1591-1593)CGC>CGT	p.R531R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.R531R	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	531	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACAGGCCCGCGACCAGGGCT	0.662													7	27					0	0	0	0	T	140779287	T	T	140779287	2	4	208	1	0	0	0	0	0	0	0	1	11620	755	27	1		1	PCDHGB5	5	140779287	Silent	SNP	C	TCGA-CV-6953-01A-11D-1912-08	8222766	140779287	40135973	32	37954											
FBXO38	81545	broad.mit.edu	37	chr5	147819261	147819261	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagtggtccctacccctatCacatctgtattatccatgaa	10	14	5	12	0	2	1	1	1	1	0	4	1	4	1	4	1	1	1	4	1	6	5			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr5:147819261C>G	uc003lpf.1	+	19	3196	c.3076C>G	c.(3076-3078)CAC>GAC	p.H1026D	FBXO38_uc003lpg.1_Missense_Mutation_p.H951D|FBXO38_uc003lph.2_Missense_Mutation_p.H781D	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	1026						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACCCCTATCACATCTGTAT	0.433													16	88					0	0	0	0	G	147819261	G	G	147819261	3	3	208	1	0	0	0	0	1	0	0	0	5778	826	29	2	3146	2	FBXO38	5	147819261	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	7039974	147819261	33095999	33	37955											
WRNIP1	56897	broad.mit.edu	37	chr6	2779537	2779537	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ataaagcagtagacaccctgGcttacctcagtgacggtgac	12	8	10	11	1	1	3	1	2	0	1	1	3	1	3	2	2	2	3	2	2	4	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:2779537G>A	uc003mtz.2	+	4	1488	c.1297G>A	c.(1297-1299)GCT>ACT	p.A433T	WRNIP1_uc003mua.2_Missense_Mutation_p.A408T	NM_020135	NP_064520	Q96S55	WRIP1_HUMAN	Werner helicase interacting protein isoform 1	433					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				AGACACCCTGGCTTACCTCAG	0.532													22	67					0	0	0	0	A	2779537	A	A	2779537	3	1	208	1	0	0	0	0	1	0	0	0	17471	1203	42	4	1311	4	WRNIP1	6	2779537	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08		2779537	168335530	34	37956											
MBOAT1	154141	broad.mit.edu	37	chr6	20124638	20124638	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagctactccatcaaacttaCctaatgtccatgcaaagtaa	15	10	4	12	0	1	0	1	0	0	0	3	0	3	0	3	0	5	3	3	0	6	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:20124638C>T	uc003ncx.1	-	8	1112	c.907_splice	c.e8+1	p.A303_splice	MBOAT1_uc011dji.1_Splice_Site_p.A154_splice	NM_001080480	NP_001073949	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain						phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			ATCAAACTTACCTAATGTCCA	0.428													12	45					0	0	0	0	T	20124638	T	T	20124638	5	4	208	1	0	0	0	0	0	0	1	0	9409	521	18	4	603	4	MBOAT1	6	20124638	Splice_Site	SNP	C	TCGA-CV-6953-01A-11D-1912-08	17345101	20124638	150990429	35	37957											
KCTD20	222658	broad.mit.edu	37	chr6	36449469	36449469	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtgccacattgttgtgctGacggatgaggattctgtgga	8	12	15	6	1	1	2	0	2	1	0	1	6	1	5	1	3	2	2	1	3	0	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:36449469G>C	uc003ome.2	+	6	1180	c.789G>C	c.(787-789)CTG>CTC	p.L263L	KCTD20_uc011dtm.1_Silent_p.L118L|KCTD20_uc011dtn.1_Silent_p.L17L|KCTD20_uc010jwk.2_Silent_p.L97L|KCTD20_uc011dto.1_Silent_p.L17L	NM_173562	NP_775833	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerisation domain	263						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2						TTGTTGTGCTGACGGATGAGG	0.507													8	54					0	0	0	0	C	36449469	C	C	36449469	2	2	208	1	0	0	0	0	0	0	0	1	8147	1277	45	2		2	KCTD20	6	36449469	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	16324831	36449469	134665598	36	37958											
MEA1	4201	broad.mit.edu	37	chr6	42980233	42980233	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggcaggggatgcctgcCgggcttggagggctttctgt	4	10	17	10	1	1	0	0	0	1	0	2	2	2	2	3	6	2	3	3	6	0	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:42980233C>T	uc003otk.2	-	4	600	c.533G>A	c.(532-534)CGG>CAG	p.R178Q	MEA1_uc010jyc.1_Intron|KLHDC3_uc003otl.2_5'Flank|KLHDC3_uc003otm.2_5'Flank|KLHDC3_uc010jyf.2_5'Flank|KLHDC3_uc003otn.2_5'Flank	NM_014623	NP_055438	Q16626	MEA1_HUMAN	male-enhanced antigen	178					cell differentiation|male gonad development|spermatogenesis		protein binding			central_nervous_system(1)|skin(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GGATGCCTGCCGGGCTTGGAG	0.582													37	172					0	0	0	0	T	42980233	T	T	42980233	3	4	208	1	0	0	0	0	1	0	0	0	9473	652	23	1	28	1	MEA1	6	42980233	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	6530764	42980233	128134834	37	37959											
SLC35F1	222553	broad.mit.edu	37	chr6	118228943	118228943	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccgccgtcgccagccccGccgaaccatgtggtgaccac	7	4	11	19	5	0	1	0	1	0	0	1	2	0	1	8	1	3	0	8	1	1	0			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr6:118228943G>A	uc003pxx.3	+	1	255	c.54G>A	c.(52-54)CCG>CCA	p.P18P		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	18					transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		CGCCAGCCCCGCCGAACCATG	0.746													14	16					0	0	0	0	A	118228943	A	A	118228943	2	1	208	1	0	0	0	0	0	0	0	1	14652	1074	38	1		1	SLC35F1	6	118228943	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	75248710	118228943	52886124	38	37960											
DNAH11	8701	broad.mit.edu	37	chr7	21639665	21639665	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatgatcttgtagaagaaatGttatgcaatagttttagaat	15	16	8	2	0	1	4	0	1	1	3	1	4	1	4	0	0	1	4	0	0	9	7			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:21639665G>T	uc003svc.2	+	15	2959	c.2928G>T	c.(2926-2928)ATG>ATT	p.M976I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	976	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TAGAAGAAATGTTATGCAATA	0.373									Kartagener_syndrome				5	94					5.9392e-07	4.16174e-06	1	0	T	21639665	T	T	21639665	3	4	208	1	0	0	0	0	1	0	0	0	4621	1377	48	4	2986	4	DNAH11	7	21639665	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08		21639665	137498998	39	37961											
GTF2I	2969	broad.mit.edu	37	chr7	74105332	74105332	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aactggccaagtccaaagccGaagtggcctgcattgcagtg	11	7	12	11	1	0	0	0	0	0	0	1	1	1	0	4	2	4	2	4	2	4	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:74105332G>A	uc003uau.2	+	3	497	c.127G>A	c.(127-129)GAA>AAA	p.E43K	GTF2I_uc003uat.2_Missense_Mutation_p.E43K|GTF2I_uc003uav.2_Missense_Mutation_p.E43K|GTF2I_uc003uaw.2_Missense_Mutation_p.E43K|GTF2I_uc003uay.2_Missense_Mutation_p.E43K|GTF2I_uc003uax.2_Missense_Mutation_p.E43K	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	43					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						GTCCAAAGCCGAAGTGGCCTG	0.408													43	126					0	0	0	0	A	74105332	A	A	74105332	3	1	208	1	0	0	0	0	1	0	0	0	6906	1059	37	1	133	1	GTF2I	7	74105332	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	52465667	74105332	85033331	40	37962											
ZNF804B	219578	broad.mit.edu	37	chr7	88963666	88963666	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggccacaccactcttcaatGgcctacggaacttctgctct	8	11	7	15	1	4	0	1	0	3	0	4	1	4	1	3	3	3	1	3	3	3	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:88963666G>C	uc011khi.1	+	4	1908	c.1370G>C	c.(1369-1371)TGG>TCG	p.W457S		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	457						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ACTCTTCAATGGCCTACGGAA	0.418										HNSCC(36;0.09)			12	63					0	0	0	0	C	88963666	C	C	88963666	3	2	208	1	0	0	0	0	1	0	0	0	18238	1357	47	4	1384	4	ZNF804B	7	88963666	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	14858334	88963666	70174997	41	37963											
TAS2R16	50833	broad.mit.edu	37	chr7	122635071	122635071	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtgctatgatgttgtatCtgcttggtcagtgatgccat	7	15	11	8	0	2	2	1	2	1	0	2	2	2	2	2	1	3	4	2	1	2	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:122635071C>A	uc003vkl.1	-	1	684	c.618G>T	c.(616-618)CAG>CAT	p.Q206H		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	206	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						GATGTTGTATCTGCTTGGTCA	0.463													18	92					1.00905e-13	7.39203e-13	1	0	A	122635071	A	A	122635071	3	1	208	1	0	0	0	0	1	0	0	0	15635	912	32	2	261	2	TAS2R16	7	122635071	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	33671405	122635071	36503592	42	37964											
PAX4	5078	broad.mit.edu	37	chr7	127253563	127253563	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttccacgggccactgaatCaggatactgcccacgctgga	9	8	10	14	2	1	1	1	1	0	0	2	3	2	3	3	3	2	1	3	3	2	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:127253563C>T	uc010lld.1	-	5	768	c.562G>A	c.(562-564)GAT>AAT	p.D188N	PAX4_uc003vmf.2_Missense_Mutation_p.D186N|PAX4_uc003vmg.1_Missense_Mutation_p.D188N|PAX4_uc003vmh.2_Missense_Mutation_p.D186N	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	196	Homeobox.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCACTGAATCAGGATACTGC	0.577													15	55					0	0	0	0	T	127253563	T	T	127253563	3	4	208	1	0	0	0	0	1	0	0	0	11535	826	29	2	489	2	PAX4	7	127253563	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	4618492	127253563	31885100	43	37965											
AGK	55750	broad.mit.edu	37	chr7	141333766	141333766	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatctttcagagatgctggCgtcaaagttagcaagtaaag	13	10	12	6	1	3	1	2	0	1	1	3	3	3	2	0	2	2	4	0	2	5	3	rs144977618		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:141333766C>T	uc003vwi.2	+	10	825	c.654C>T	c.(652-654)GGC>GGT	p.G218G	AGK_uc011krg.1_RNA	NM_018238	NP_060708	Q53H12	AGK_HUMAN	acylglycerol kinase precursor	218					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			ovary(1)|breast(1)	2	Melanoma(164;0.0171)					GAGATGCTGGCGTCAAAGTTA	0.368													22	60					0	0	0	0	T	141333766	T	T	141333766	2	4	208	1	0	0	0	0	0	0	0	1	383	755	27	1		1	AGK	7	141333766	Silent	SNP	C	TCGA-CV-6953-01A-11D-1912-08	14080203	141333766	17804897	44	37966											
SLC4A2	6522	broad.mit.edu	37	chr7	150771490	150771490	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgcctgcccactcagatccGgcgggtgattggggactttg	5	10	15	11	2	1	2	1	1	0	1	2	3	2	3	3	4	2	0	3	4	0	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr7:150771490G>A	uc003wit.3	+	18	3051	c.2795G>A	c.(2794-2796)CGG>CAG	p.R932Q	SLC4A2_uc011kve.1_Missense_Mutation_p.R923Q|SLC4A2_uc003wiu.3_Missense_Mutation_p.R918Q|SLC4A2_uc003wiv.3_Missense_Mutation_p.R126Q	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	932	Membrane (anion exchange).|Cytoplasmic (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACTCAGATCCGGCGGGTGATT	0.597													35	98					0	0	0	0	A	150771490	A	A	150771490	3	1	208	1	0	0	0	0	1	0	0	0	14718	1116	39	1	2861	1	SLC4A2	7	150771490	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	9437724	150771490	8367173	45	37967											
NEIL2	252969	broad.mit.edu	37	chr8	11637389	11637389	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctttggtttgtttggcagcGtttgggtgaacgatttctcc	4	17	13	7	2	1	1	0	1	1	0	2	2	1	1	1	3	2	5	1	3	1	5	rs113905789		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr8:11637389G>A	uc003wug.2	+	3	1096	c.421G>A	c.(421-423)GTT>ATT	p.V141I	NEIL2_uc003wue.2_Missense_Mutation_p.V141I|NEIL2_uc003wuf.2_Missense_Mutation_p.V80I|NEIL2_uc011kxd.1_Intron	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	141					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		GTTTGGCAGCGTTTGGGTGAA	0.572								BER_DNA_glycosylases					34	75					0	0	0	0	A	11637389	A	A	11637389	3	1	208	1	0	0	0	0	1	0	0	0	10373	1145	40	1	432	1	NEIL2	8	11637389	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08		11637389	134726633	46	37968											
PSD3	23362	broad.mit.edu	37	chr8	18725364	18725364	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actgaccaccttctttaatgCgctgttgtatcattggagtg	8	15	9	9	1	2	1	1	1	1	0	2	2	2	2	2	1	1	3	2	1	2	6			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr8:18725364C>T	uc003wza.2	-	4	1557	c.1454G>A	c.(1453-1455)CGC>CAC	p.R485H		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	485					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TTCTTTAATGCGCTGTTGTAT	0.463													45	154					0	0	0	0	T	18725364	T	T	18725364	3	4	208	1	0	0	0	0	1	0	0	0	12710	768	27	1	1777	1	PSD3	8	18725364	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	7087975	18725364	127638658	47	37969											
MYST3	7994	broad.mit.edu	37	chr8	41791631	41791631	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctcttcggaatccagctcGgtttcctctttatcctttat	5	18	5	13	2	2	0	0	0	2	0	8	1	6	1	4	2	1	2	4	2	3	6			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr8:41791631G>A	uc010lxb.2	-	18	4651	c.4107C>T	c.(4105-4107)ACC>ACT	p.T1369T	MYST3_uc010lxc.2_Silent_p.T1369T|MYST3_uc003xon.3_Silent_p.T1369T	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1369					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			AATCCAGCTCGGTTTCCTCTT	0.502													15	93					0	0	0	0	A	41791631	A	A	41791631	2	1	208	1	0	0	0	0	0	0	0	1	10157	1103	39	1		1	MYST3	8	41791631	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	23066267	41791631	104572391	48	37970											
DENND4C	55667	broad.mit.edu	37	chr9	19346744	19346744	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatgctctagagaggagatCaagcctacctttagatcatg	12	11	9	9	0	4	3	3	0	1	3	4	5	4	3	2	1	3	1	2	1	4	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:19346744C>G	uc003znq.2	+	18	3155	c.3122C>G	c.(3121-3123)TCA>TGA	p.S1041*	DENND4C_uc011lnc.1_Nonsense_Mutation_p.S371*|DENND4C_uc011lnd.1_Nonsense_Mutation_p.S329*|DENND4C_uc003znr.2_Nonsense_Mutation_p.S329*|DENND4C_uc003zns.2_Nonsense_Mutation_p.S223*|DENND4C_uc003znt.2_Nonsense_Mutation_p.S223*	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1041						integral to membrane				ovary(1)|skin(1)	2						GAGAGGAGATCAAGCCTACCT	0.433													12	93					0	0	0	0	G	19346744	G	G	19346744	4	3	208	1	0	0	0	0	0	1	0	0	4457	838	29	2	3192	2	DENND4C	9	19346744	Nonsense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08		19346744	121866687	49	37971											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	6					0	0	0	0	A	21971120	A	A	21971120	4	1	208	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	2624376	21971120	119242311	50	37972											
KIF24	347240	broad.mit.edu	37	chr9	34290194	34290194	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttcttctatttaggaggtCataaagctgtccacagtaaa	12	15	7	7	0	3	0	1	0	2	0	4	1	4	1	1	2	1	2	1	2	6	8			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:34290194C>T	uc003zua.3	-	5	1225	c.1105G>A	c.(1105-1107)GAC>AAC	p.D369N	KIF24_uc010mkb.2_Missense_Mutation_p.D400N	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	369	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			TTTAGGAGGTCATAAAGCTGT	0.413													22	82					0	0	0	0	T	34290194	T	T	34290194	3	4	208	1	0	0	0	0	1	0	0	0	8331	826	29	2	3037	2	KIF24	9	34290194	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	12319074	34290194	106923237	51	37973											
RECK	8434	broad.mit.edu	37	chr9	36110025	36110025	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatttggtgtgctctaccCgcctttgcctcagtgagcac	6	12	10	13	1	2	1	1	1	1	0	2	1	2	1	3	1	4	3	3	1	2	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	b816cd3e-1589-428c-8bf6-fd5cc32bf3a0	g.chr9:36110025C>A	uc003zyv.2	+	15	1923	c.1837C>A	c.(1837-1839)CGC>AGC	p.R613S	RECK_uc003zyw.2_Missense_Mutation_p.R485S|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	613						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GTGCTCTACCCGCCTTTGCCT	0.473													6	153					0.00198382	0.00984924	1	0	A	36110025	A	A	36110025	3	1	208	1	0	0	0	0	1	0	0	0	13265	652	23	3	1895	3	RECK	9	36110025	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	1819831	36110025	105103406	52	37974											
IARS	3376	broad.mit.edu	37	chr9	95043159	95043159	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagggaaagttacaaatactGaaggatcttgaacatcctga	17	9	9	6	0	1	3	0	3	1	0	2	5	2	5	1	2	3	1	1	2	7	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:95043159G>A	uc004art.1	-	7	871	c.614C>T	c.(613-615)TCA>TTA	p.S205L	IARS_uc004ars.1_Missense_Mutation_p.S50L|IARS_uc004aru.3_Missense_Mutation_p.S205L|IARS_uc010mqr.2_Missense_Mutation_p.S95L|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	205					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	TACAAATACTGAAGGATCTTG	0.368													5	35					0	0	0	0	A	95043159	A	A	95043159	3	1	208	1	0	0	0	0	1	0	0	0	7512	1294	45	2	3286	2	IARS	9	95043159	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	58933134	95043159	46170272	53	37975											
CTNNAL1	8727	broad.mit.edu	37	chr9	111745573	111745573	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttttatgggctgattcgCagttaggatgcctcagacat	8	15	11	7	1	1	2	1	1	0	1	2	3	1	3	1	2	1	4	1	2	2	5			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:111745573C>T	uc004bdo.1	-	6	794	c.752G>A	c.(751-753)TGC>TAC	p.C251Y	CTNNAL1_uc010mts.1_5'UTR|CTNNAL1_uc010mtt.1_Missense_Mutation_p.C251Y|CTNNAL1_uc004bdp.1_Missense_Mutation_p.C251Y	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	251					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		GGCTGATTCGCAGTTAGGATG	0.338													10	41					0	0	0	0	T	111745573	T	T	111745573	3	4	208	1	0	0	0	0	1	0	0	0	4032	710	25	4	1508	4	CTNNAL1	9	111745573	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	16702414	111745573	29467858	54	37976											
OLFM1	10439	broad.mit.edu	37	chr9	138011897	138011897	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcgacatcccattccagaAcaaatactcccacatctcca	14	8	2	17	1	1	1	0	0	1	1	6	2	4	1	4	0	2	0	4	0	3	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr9:138011897A>G	uc010nar.2	+	6	1647	c.1331A>G	c.(1330-1332)AAC>AGC	p.N444S	OLFM1_uc004cfl.3_Missense_Mutation_p.N426S|OLFM1_uc004cfn.3_Missense_Mutation_p.N195S	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	444	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		CCATTCCAGAACAAATACTCC	0.537													13	82					0	0	0	0	G	138011897	G	G	138011897	3	3	208	1	0	0	0	0	1	0	0	0	10906	43	2	5	1309	5	OLFM1	9	138011897	Missense_Mutation	SNP	A	TCGA-CV-6953-01A-11D-1912-08	26266324	138011897	3201534	55	37977											
ITGB1	3688	broad.mit.edu	37	chr10	33211200	33211200	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcacattgtatgcatcaatGatcaactgaattacattgct	13	14	5	9	0	3	2	3	2	0	0	3	2	3	2	0	0	4	3	0	0	5	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr10:33211200G>C	uc001iws.3	-	9	1249	c.1113C>G	c.(1111-1113)ATC>ATG	p.I371M	ITGB1_uc001iwp.3_Missense_Mutation_p.I371M|ITGB1_uc001iwq.3_Missense_Mutation_p.I371M|ITGB1_uc001iwr.3_Missense_Mutation_p.I371M|ITGB1_uc001iwt.3_Missense_Mutation_p.I371M|ITGB1_uc001iwu.1_Missense_Mutation_p.I371M	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	371	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				ATGCATCAATGATCAACTGAA	0.328													19	79					0	0	0	0	C	33211200	C	C	33211200	3	2	208	1	0	0	0	0	1	0	0	0	7929	1280	45	2	1553	2	ITGB1	10	33211200	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08		33211200	102323547	56	37978											
ZNF33B	7582	broad.mit.edu	37	chr10	43090020	43090020	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaagaacttacgtccatgttAaatggtattcctattacatt	14	15	5	7	1	0	1	0	0	0	1	2	1	2	1	2	1	3	2	2	1	8	7			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr10:43090020A>T	uc001jaf.1	-	5	493	c.378T>A	c.(376-378)TTT>TTA	p.F126L	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.F14L|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	126						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CGTCCATGTTAAATGGTATTC	0.348													11	66					0	0	0	0	T	43090020	T	T	43090020	3	4	208	1	0	0	0	0	1	0	0	0	17922	359	13	5	1962	5	ZNF33B	10	43090020	Missense_Mutation	SNP	A	TCGA-CV-6953-01A-11D-1912-08	9878820	43090020	92444727	57	37979											
PHYHIPL	84457	broad.mit.edu	37	chr10	61005100	61005100	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgggatcaccaggagatGaattttgtaagcagcgcctt	10	11	12	8	1	1	2	1	1	0	1	1	4	1	3	2	2	2	2	2	2	2	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr10:61005100G>T	uc001jkk.3	+	5	1146	c.880G>T	c.(880-882)GAA>TAA	p.E294*	PHYHIPL_uc001jkl.3_Nonsense_Mutation_p.E248*|PHYHIPL_uc001jkm.3_Nonsense_Mutation_p.E268*	NM_032439	NP_115815	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting	294											0						ACCAGGAGATGAATTTTGTAA	0.403													19	55					9.95505e-16	7.46243e-15	1	0	T	61005100	T	T	61005100	4	4	208	1	0	0	0	0	0	1	0	0	11922	1291	45	2	930	2	PHYHIPL	10	61005100	Nonsense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	17915080	61005100	74529647	58	37980											
INPP5F	22876	broad.mit.edu	37	chr10	121582640	121582640	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcatgcgactgcactacaGatacaaagaagcgagtggct	13	7	11	10	2	0	2	0	0	0	2	0	4	0	2	0	1	6	3	0	1	4	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr10:121582640G>C	uc001leo.2	+	18	2256	c.2090G>C	c.(2089-2091)AGA>ACA	p.R697T	INPP5F_uc001lep.2_Missense_Mutation_p.R87T	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	697							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CTGCACTACAGATACAAAGAA	0.403													3	58					0	0	0	0	C	121582640	C	C	121582640	3	2	208	1	0	0	0	0	1	0	0	0	7797	942	33	2	2160	2	INPP5F	10	121582640	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	60577540	121582640	13952107	59	37981											
OR51I2	390064	broad.mit.edu	37	chr11	5475541	5475541	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccatgctacatacatgtcCtcatgtcaaatgtgtaccta	11	13	5	12	0	2	0	2	0	0	0	4	0	4	0	3	0	4	2	3	0	5	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr11:5475541C>A	uc010qzf.1	+	1	823	c.823C>A	c.(823-825)CTC>ATC	p.L275I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATACATGTCCTCATGTCAAA	0.473													47	158					1.23713e-20	9.41971e-20	1	0	A	5475541	A	A	5475541	3	1	208	1	0	0	0	0	1	0	0	0	11155	681	24	4	825	4	OR51I2	11	5475541	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08		5475541	129530975	60	37982											
SLC1A2	6506	broad.mit.edu	37	chr11	35308365	35308365	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttgggctataaagatggCggctaccgcttcataaaggg	11	10	12	8	2	1	1	1	0	0	1	1	1	1	1	1	4	1	3	1	4	6	6			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr11:35308365C>T	uc001mwd.2	-	8	1817	c.1225G>A	c.(1225-1227)GCC>ACC	p.A409T	SLC1A2_uc001mwe.2_Missense_Mutation_p.A400T|SLC1A2_uc010rev.1_Missense_Mutation_p.A409T	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	409	Helical; (Potential).				D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	ATAAAGATGGCGGCTACCGCT	0.468													17	141					0	0	0	0	T	35308365	T	T	35308365	3	4	208	1	0	0	0	0	1	0	0	0	14497	768	27	1	515	1	SLC1A2	11	35308365	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	29832824	35308365	99698151	61	37983											
OR5D18	219438	broad.mit.edu	37	chr11	55587492	55587492	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgcttcgtggccatttgcaaCcctctgctctacacagttaa	8	12	7	14	2	2	0	0	0	2	0	3	0	2	0	2	1	4	4	2	1	3	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr11:55587492C>T	uc010rin.1	+	1	387	c.387C>T	c.(385-387)AAC>AAT	p.N129N		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				CCATTTGCAACCCTCTGCTCT	0.478													44	159					0	0	0	0	T	55587492	T	T	55587492	2	4	208	1	0	0	0	0	0	0	0	1	11211	506	18	4		4	OR5D18	11	55587492	Silent	SNP	C	TCGA-CV-6953-01A-11D-1912-08	20279127	55587492	79419024	62	37984											
OR4D6	219983	broad.mit.edu	37	chr11	59225310	59225310	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctattccctgagaaatcaaGagatgaagtcagccatgcag	14	9	9	9	0	3	3	2	2	1	2	4	5	4	3	2	0	2	1	2	0	4	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr11:59225310G>A	uc010rku.1	+	1	877	c.877G>A	c.(877-879)GAG>AAG	p.E293K		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAGAAATCAAGAGATGAAGTC	0.522													44	117					0	0	0	0	A	59225310	A	A	59225310	3	1	208	1	0	0	0	0	1	0	0	0	11112	943	33	2	879	2	OR4D6	11	59225310	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	3637818	59225310	75781206	63	37985											
ARHGEF12	23365	broad.mit.edu	37	chr11	120291479	120291479	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggtcttgttcagcgttgcGtaatcatccagaaagatgac	11	11	10	9	2	3	3	2	1	1	2	4	3	4	3	1	1	2	3	1	1	2	4	rs34754222		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr11:120291479G>A	uc001pxl.1	+	5	224	c.217G>A	c.(217-219)GTA>ATA	p.V73I	ARHGEF12_uc009zat.2_Missense_Mutation_p.V54I|ARHGEF12_uc010rzn.1_5'UTR|ARHGEF12_uc009zau.1_5'UTR	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	73	PDZ.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TCAGCGTTGCGTAATCATCCA	0.383			T	MLL	AML								23	48					0	0	0	0	A	120291479	A	A	120291479	3	1	208	1	0	0	0	0	1	0	0	0	897	1145	40	1	235	1	ARHGEF12	11	120291479	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	61066169	120291479	14715037	64	37986											
ACRBP	84519	broad.mit.edu	37	chr12	6749669	6749669	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaggtagacatgtgtcgcCgcccaaggctgtcacagacc	10	6	11	14	2	1	2	1	0	0	2	2	2	1	2	3	2	0	2	3	2	2	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:6749669C>T	uc001qpu.1	-	7	1145	c.1097G>A	c.(1096-1098)CGG>CAG	p.R366Q	LPAR5_uc010sff.1_5'Flank|ACRBP_uc001qpt.1_5'Flank|ACRBP_uc010sfg.1_Missense_Mutation_p.R333Q	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	366						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						CATGTGTCGCCGCCCAAGGCT	0.637													8	23					0	0	0	0	T	6749669	T	T	6749669	3	4	208	1	0	0	0	0	1	0	0	0	170	652	23	1	550	1	ACRBP	12	6749669	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08		6749669	127102226	65	37987											
CLEC12B	387837	broad.mit.edu	37	chr12	10167883	10167883	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccatgtcctaagatgtggCaatggtaccaaaatagttgc	13	11	9	8	0	0	1	0	0	0	1	2	1	2	1	3	2	2	3	3	2	6	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:10167883C>T	uc001qwz.2	+	4	570	c.442C>T	c.(442-444)CAA>TAA	p.Q148*	CLEC12B_uc001qwx.1_Nonsense_Mutation_p.Q148*|CLEC12B_uc001qwy.1_Nonsense_Mutation_p.Q45*|CLEC12B_uc009zhe.2_RNA	NM_001129998	NP_001123470	Q2HXU8	CL12B_HUMAN	C-type lectin domain family 12, member B isoform	148	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity|sugar binding				0						TAAGATGTGGCAATGGTACCA	0.388													23	94					0	0	0	0	T	10167883	T	T	10167883	4	4	208	1	0	0	0	0	0	1	0	0	3513	711	25	4	456	4	CLEC12B	12	10167883	Nonsense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	3418214	10167883	123684012	66	37988											
PTPRO	5800	broad.mit.edu	37	chr12	15742441	15742441	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccctggacaggctcttgcagCacattcgggatcatgagttt	8	11	11	11	1	2	1	1	1	1	0	3	3	2	3	1	3	2	4	1	3	0	3	rs61757814		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:15742441C>T	uc001rcv.1	+	25	3637	c.3463C>T	c.(3463-3465)CAC>TAC	p.H1155Y	PTPRO_uc001rcw.1_Missense_Mutation_p.H1127Y|PTPRO_uc001rcx.1_Missense_Mutation_p.H344Y|PTPRO_uc001rcy.1_Missense_Mutation_p.H344Y|PTPRO_uc001rcz.1_Missense_Mutation_p.H316Y|PTPRO_uc001rda.1_Missense_Mutation_p.H316Y	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	1155	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GCTCTTGCAGCACATTCGGGA	0.463													29	77					0	0	0	0	T	15742441	T	T	15742441	3	4	208	1	0	0	0	0	1	0	0	0	12874	710	25	4	3561	4	PTPRO	12	15742441	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	5574558	15742441	118109454	67	37989											
ABCC9	10060	broad.mit.edu	37	chr12	21981956	21981956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcaatgttgtttgtatccGtcagttccagcatacgttgt	8	15	10	8	2	1	0	1	0	0	0	3	0	3	0	2	1	2	7	2	1	3	6			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:21981956G>A	uc001rfi.1	-	29	3625	c.3605C>T	c.(3604-3606)ACG>ATG	p.T1202M	ABCC9_uc001rfh.2_Missense_Mutation_p.T1202M|ABCC9_uc001rfj.1_Missense_Mutation_p.T1166M	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1202	Extracellular (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTTTGTATCCGTCAGTTCCAG	0.413													19	95					0	0	0	0	A	21981956	A	A	21981956	3	1	208	1	0	0	0	0	1	0	0	0	59	1145	40	1	1226	1	ABCC9	12	21981956	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	6239515	21981956	111869939	68	37990											
DENND5B	160518	broad.mit.edu	37	chr12	31552693	31552693	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctgaacagtggtcagcttcCccaagttctggcactgtagg	8	11	11	11	0	3	1	1	1	2	0	4	1	4	1	2	3	2	4	2	3	3	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:31552693C>T	uc001rki.1	-	16	3149	c.2963G>A	c.(2962-2964)GGG>GAG	p.G988E	DENND5B_uc001rkh.1_Missense_Mutation_p.G1023E|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	988	PLAT.					integral to membrane				ovary(1)|central_nervous_system(1)	2						GGTCAGCTTCCCCAAGTTCTG	0.443													5	33					0	0	0	0	T	31552693	T	T	31552693	3	4	208	1	0	0	0	0	1	0	0	0	4459	623	22	4	885	4	DENND5B	12	31552693	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	9570737	31552693	102299202	69	37991											
ESPL1	9700	broad.mit.edu	37	chr12	53671305	53671305	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtaacttggaggaatttGaagtcaatgacctgaactat	13	12	10	6	0	1	3	1	3	0	0	1	5	1	5	1	3	2	1	1	3	6	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:53671305G>A	uc001sck.2	+	10	2228	c.2137G>A	c.(2137-2139)GAA>AAA	p.E713K	ESPL1_uc001scj.2_Missense_Mutation_p.E388K|ESPL1_uc010soe.1_5'Flank	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	713					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GGAGGAATTTGAAGTCAATGA	0.433													16	38					0	0	0	0	A	53671305	A	A	53671305	3	1	208	1	0	0	0	0	1	0	0	0	5277	1291	45	2	2171	2	ESPL1	12	53671305	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	22118612	53671305	80180590	70	37992											
PDE1B	5153	broad.mit.edu	37	chr12	54968993	54968993	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggccctcatggaggaattCttccgtcaggtagcgtggca	9	9	13	10	2	3	0	2	0	1	0	4	2	4	2	2	5	1	2	2	5	3	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:54968993C>G	uc001sgd.1	+	11	1342	c.1176C>G	c.(1174-1176)TTC>TTG	p.F392L	PDE1B_uc010soz.1_Missense_Mutation_p.F255L|PDE1B_uc010spa.1_Missense_Mutation_p.F351L|PDE1B_uc001sgf.2_Missense_Mutation_p.F255L|PDE1B_uc001sge.2_Missense_Mutation_p.F372L|PDE1B_uc009znq.2_Missense_Mutation_p.F188L	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	392	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGGAGGAATTCTTCCGTCAGG	0.577													27	85					0	0	0	0	G	54968993	G	G	54968993	3	3	208	1	0	0	0	0	1	0	0	0	11688	912	32	2	1271	2	PDE1B	12	54968993	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	1297688	54968993	78882902	71	37993											
CDK4	1019	broad.mit.edu	37	chr12	58143273	58143273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	actggtcggcttcagagtttCcacagaagagaggcctaagg	11	8	13	9	1	1	3	1	0	0	3	3	4	2	3	2	4	0	2	2	4	2	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:58143273C>T	uc001spv.2	-	6	874	c.647G>A	c.(646-648)GGA>GAA	p.G216E	CDK4_uc010ssb.1_Missense_Mutation_p.G96E|CDK4_uc001spw.2_RNA|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	216	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			TTCAGAGTTTCCACAGAAGAG	0.418			Mis			melanoma 			Hereditary_Melanoma				6	29					0	0	0	0	T	58143273	T	T	58143273	3	4	208	1	0	0	0	0	1	0	0	0	3156	855	30	2	276	2	CDK4	12	58143273	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	3174280	58143273	75708622	72	37994											
SYT1	6857	broad.mit.edu	37	chr12	79685859	79685859	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaacccaaagaagaggaGaaactgggaaaacttcagta	20	4	11	6	0	1	4	1	0	0	4	1	7	1	5	1	2	3	1	1	2	8	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr12:79685859G>T	uc001sys.2	+	7	1094	c.423G>T	c.(421-423)GAG>GAT	p.E141D	SYT1_uc001syt.2_Missense_Mutation_p.E141D|SYT1_uc001syu.2_Missense_Mutation_p.E138D|SYT1_uc001syv.2_Missense_Mutation_p.E141D	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	141	Cytoplasmic (Potential).|Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						AAGAAGAGGAGAAACTGGGAA	0.368													10	37					7.48243e-07	5.2054e-06	1	0	T	79685859	T	T	79685859	3	4	208	1	0	0	0	0	1	0	0	0	15531	933	33	2	433	2	SYT1	12	79685859	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	21542586	79685859	54166036	73	37995											
GALNT4	8693	broad.mit.edu	37	chr12	89919631	89919632	+	5'Flank	DEL	CC	-	-																															ggacaggctccagggagggaCcccccccacctccaacccgt																								rs67346689		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	b816cd3e-1589-428c-8bf6-fd5cc32bf3a0	g.chr12:89919631_89919632delCC	uc001tbd.2	-						POC1B_uc001tba.2_5'Flank|POC1B_uc001tbb.2_5'Flank|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Intron|GALNT4_uc010suo.1_Intron	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4						carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						CAGGGAGGGACCCCCCCCACCT	0.668													---	---	---								-	89919632	-	-	89919631	6	5	208	0	1	1	0	1	0	0	0	0	6250	522	18	0		0	GALNT4	12	89919631	5'Flank	DEL	CC	TCGA-CV-6953-01A-11D-1912-08	10233772	89919631	43932264	74	37996											
PSPC1	55269	broad.mit.edu	37	chr13	20325582	20325582	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcaaatgtcccaggttgagCaaaacgtggtggttgttctc	9	13	11	8	1	2	1	1	1	1	0	4	1	3	1	1	3	2	4	1	3	3	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr13:20325582C>A	uc001uml.2	-	4	982	c.796G>T	c.(796-798)GCT>TCT	p.A266S	PSPC1_uc001umj.1_RNA|PSPC1_uc001umk.1_RNA	NM_001042414	NP_001035879	Q8WXF1	PSPC1_HUMAN	paraspeckle protein 1	266	Sufficient for perinucleolar caps localization and interaction with NONO.|Sufficient for paraspeckles localization.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)	1		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		CCAGGTTGAGCAAAACGTGGT	0.378													12	41					0.000978159	0.00647863	1	0	A	20325582	A	A	20325582	3	1	208	1	0	0	0	0	1	0	0	0	12778	710	25	4	799	4	PSPC1	13	20325582	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08		20325582	94844296	75	37997											
ATP7B	540	broad.mit.edu	37	chr13	52542595	52542595	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttactgtcagctcaatgttGccatcggagcctgcgtagtc	7	12	10	12	2	2	0	2	0	0	0	4	1	2	1	2	1	5	3	2	1	3	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr13:52542595G>A	uc001vfw.2	-	4	1849	c.1692C>T	c.(1690-1692)GGC>GGT	p.G564G	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Silent_p.G564G|ATP7B_uc001vfy.2_Silent_p.G453G|ATP7B_uc010tgt.1_Silent_p.G564G|ATP7B_uc010tgu.1_Silent_p.G564G|ATP7B_uc010tgv.1_Silent_p.G564G|ATP7B_uc010tgw.1_Intron	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	564	Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GCTCAATGTTGCCATCGGAGC	0.498									Wilson_disease				8	39					0	0	0	0	A	52542595	A	A	52542595	2	1	208	1	0	0	0	0	0	0	0	1	1193	1306	46	4		4	ATP7B	13	52542595	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	32217013	52542595	62627283	76	37998											
DACH1	1602	broad.mit.edu	37	chr13	72053410	72053410	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccagttggacctgtttctcTtgagctctggcattatctat	6	17	8	10	0	3	1	0	1	3	0	5	2	4	2	2	2	1	4	2	2	2	5			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr13:72053410T>C	uc010thn.1	-	9	2184	c.1761A>G	c.(1759-1761)CAA>CAG	p.Q587Q	DACH1_uc010tho.1_Silent_p.Q439Q|DACH1_uc010thp.1_Silent_p.Q385Q	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	639	DACHbox-C.|Potential.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CCTGTTTCTCTTGAGCTCTGG	0.373													20	86					0	0	0	0	C	72053410	C	C	72053410	2	2	208	1	0	0	0	0	0	0	0	1	4237	1606	56	5		5	DACH1	13	72053410	Silent	SNP	T	TCGA-CV-6953-01A-11D-1912-08	19510815	72053410	43116468	77	37999											
MYH7	4625	broad.mit.edu	37	chr14	23886750	23886750	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttcttgtccagggctgcagCagcagcattggagcgctcta	7	10	12	12	1	2	0	0	0	2	0	3	1	3	1	1	2	5	6	1	2	1	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:23886750C>T	uc001wjx.2	-	31	4421	c.4315G>A	c.(4315-4317)GCT>ACT	p.A1439T		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1439	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AGGGCTGCAGCAGCAGCATTG	0.602													17	86					0	0	0	0	T	23886750	T	T	23886750	3	4	208	1	0	0	0	0	1	0	0	0	10092	710	25	4	1532	4	MYH7	14	23886750	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08		23886750	83462790	78	38000											
PRKD1	5587	broad.mit.edu	37	chr14	30135410	30135410	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaaagtcttcaaaggtggcGgaagctgtaaaaatagtgat	15	10	12	4	1	2	2	1	2	1	0	2	3	2	3	0	3	1	2	0	3	7	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:30135410G>A	uc001wqh.2	-	3	589	c.408C>T	c.(406-408)TCC>TCT	p.S136S		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	136					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CAAAGGTGGCGGAAGCTGTAA	0.403													19	52					0	0	0	0	A	30135410	A	A	30135410	2	1	208	1	0	0	0	0	0	0	0	1	12580	1103	39	1		1	PRKD1	14	30135410	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	6248660	30135410	77214130	79	38001											
FBXO34	55030	broad.mit.edu	37	chr14	55818744	55818744	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagtacattaccagtgcttGaggcatccagttggaagaag	14	9	11	7	0	0	2	0	1	0	1	1	3	1	3	2	2	3	4	2	2	5	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:55818744G>C	uc001xbu.2	+	2	1881	c.1636G>C	c.(1636-1638)GAG>CAG	p.E546Q	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.E546Q	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	546										ovary(2)|lung(2)|skin(1)	5						ACCAGTGCTTGAGGCATCCAG	0.507													41	122					0	0	0	0	C	55818744	C	C	55818744	3	2	208	1	0	0	0	0	1	0	0	0	5776	1291	45	2	1638	2	FBXO34	14	55818744	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	25683334	55818744	51530796	80	38002											
ZFYVE26	23503	broad.mit.edu	37	chr14	68215205	68215205	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggtggcttgtcagaagcCactgggcacagatgtcttgc	7	9	16	9	0	2	2	1	0	1	2	2	2	2	2	1	4	2	2	1	4	1	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:68215205C>T	uc001xka.2	-	42	7707	c.7568G>A	c.(7567-7569)TGG>TAG	p.W2523*	ZFYVE26_uc010tsz.1_RNA	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2523					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TGTCAGAAGCCACTGGGCACA	0.642													4	64					0	0	0	0	T	68215205	T	T	68215205	4	4	208	1	0	0	0	0	0	1	0	0	17735	595	21	4	55	4	ZFYVE26	14	68215205	Nonsense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	12396461	68215205	39134335	81	38003											
CPSF2	53981	broad.mit.edu	37	chr14	92601740	92601740	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggcctgtctatcacacctCtgccagctggtcatatgata	9	12	8	12	0	4	1	2	1	2	0	4	1	4	1	3	2	2	1	3	2	3	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:92601740C>T	uc001yah.1	+	6	682	c.445C>T	c.(445-447)CTG>TTG	p.L149L		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	149					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		TATCACACCTCTGCCAGCTGG	0.368													14	57					0	0	0	0	T	92601740	T	T	92601740	2	4	208	1	0	0	0	0	0	0	0	1	3840	912	32	2		2	CPSF2	14	92601740	Silent	SNP	C	TCGA-CV-6953-01A-11D-1912-08	24386535	92601740	14747800	82	38004											
C14orf73	91828	broad.mit.edu	37	chr14	103573994	103573994	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcaggaggtgcaccggttCgtggtccgcgagtacctggc	5	8	16	12	4	0	0	0	0	0	0	2	2	1	1	3	5	3	4	3	5	1	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr14:103573994C>T	uc001ymk.2	+	9	1804	c.1728C>T	c.(1726-1728)TTC>TTT	p.F576F		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	576											0		Melanoma(154;0.155)	Epithelial(46;0.221)			TGCACCGGTTCGTGGTCCGCG	0.612													4	7					0	0	0	0	T	103573994	T	T	103573994	2	4	208	1	0	0	0	0	0	0	0	1	1785	883	31	1		1	C14orf73	14	103573994	Silent	SNP	C	TCGA-CV-6953-01A-11D-1912-08	10972254	103573994	3775546	83	38005											
SHC4	399694	broad.mit.edu	37	chr15	49127202	49127202	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggctgtggcacccggctGaacagtttctggtgcctctg	4	11	14	12	1	2	1	0	1	2	0	2	1	2	1	2	4	2	4	2	4	1	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr15:49127202G>A	uc001zxb.1	-	11	1930	c.1501C>T	c.(1501-1503)CAG>TAG	p.Q501*	SHC4_uc010uey.1_Nonsense_Mutation_p.Q258*|SHC4_uc010uez.1_Nonsense_Mutation_p.Q215*	NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	501	CH1.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		GCACCCGGCTGAACAGTTTCT	0.418													4	11					0	0	0	0	A	49127202	A	A	49127202	4	1	208	1	0	0	0	0	0	1	0	0	14338	1299	45	2	399	2	SHC4	15	49127202	Nonsense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08		49127202	53404190	84	38006											
SECISBP2L	9728	broad.mit.edu	37	chr15	49288750	49288750	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttatatgctttcctggcctCctcagtgagttctactaatt	7	18	6	10	0	2	1	1	1	1	0	4	1	4	1	3	1	2	2	3	1	4	8			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr15:49288750C>T	uc001zxe.1	-	17	2571	c.2437G>A	c.(2437-2439)GAG>AAG	p.E813K	SECISBP2L_uc001zxd.1_Missense_Mutation_p.E768K|SECISBP2L_uc010bep.1_Missense_Mutation_p.E575K	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	813										breast(1)|skin(1)	2						TTCCTGGCCTCCTCAGTGAGT	0.368													55	192					0	0	0	0	T	49288750	T	T	49288750	3	4	208	1	0	0	0	0	1	0	0	0	14072	864	30	2	876	2	SECISBP2L	15	49288750	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	161548	49288750	53242642	85	38007											
THSD4	79875	broad.mit.edu	37	chr15	72039251	72039251	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccgccaggttctgtgccGccaggtgtacgccaaccgca	7	6	12	16	4	1	0	0	0	1	0	1	0	1	0	6	2	3	4	6	2	2	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr15:72039251G>T	uc002atb.1	+	12	2190	c.2111G>T	c.(2110-2112)CGC>CTC	p.R704L	THSD4_uc002ate.2_Missense_Mutation_p.R344L	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	704	TSP type-1 2.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						GTTCTGTGCCGCCAGGTGTAC	0.627													13	27					1.3612e-06	9.40203e-06	1	0	T	72039251	T	T	72039251	3	4	208	1	0	0	0	0	1	0	0	0	15944	1087	38	3	2157	3	THSD4	15	72039251	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	22750501	72039251	30492141	86	38008											
CHSY1	22856	broad.mit.edu	37	chr15	101719133	101719133	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttactgttatggagatctCtaatgtacccctttttgttc	7	20	6	8	0	1	1	0	0	1	1	3	2	1	1	2	1	2	3	2	1	4	8			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr15:101719133C>G	uc002bwt.1	-	4	1352	c.869G>C	c.(868-870)AGA>ACA	p.R290T	CHSY1_uc010usd.1_Missense_Mutation_p.R18T	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	290	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATGGAGATCTCTAATGTACCC	0.398													13	57					0	0	0	0	G	101719133	G	G	101719133	3	3	208	1	0	0	0	0	1	0	0	0	3427	913	32	2	1543	2	CHSY1	15	101719133	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	29679882	101719133	812259	87	38009											
ABCA3	21	broad.mit.edu	37	chr16	2347779	2347779	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgccacaccttggagcctgcGatgagggcgatgccgatgga	8	6	15	12	4	0	1	0	1	0	0	0	6	0	3	4	3	3	0	4	3	0	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:2347779G>A	uc002cpy.1	-	16	2752	c.2040C>T	c.(2038-2040)ATC>ATT	p.I680I	ABCA3_uc010bsk.1_Silent_p.I622I|ABCA3_uc010bsl.1_Silent_p.I680I	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	680	ABC transporter 1.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				TGGAGCCTGCGATGAGGGCGA	0.662													10	54					0	0	0	0	A	2347779	A	A	2347779	2	1	208	1	0	0	0	0	0	0	0	1	33	1048	37	1		1	ABCA3	16	2347779	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08		2347779	88006974	88	38010											
ZNF174	7727	broad.mit.edu	37	chr16	3452371	3452371	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattgtgaccctcgtggaaGattttcacagagcatccaag	12	10	10	9	1	1	4	1	1	0	3	3	5	2	5	2	1	1	1	2	1	2	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:3452371G>T	uc002cvc.2	+	1	1182	c.367G>T	c.(367-369)GAT>TAT	p.D123Y	ZNF434_uc002cux.3_5'Flank|ZNF434_uc010uwx.1_5'Flank|ZNF434_uc002cuy.3_5'Flank|ZNF434_uc002cuz.2_5'Flank|ZNF434_uc010uwy.1_5'Flank|ZNF434_uc010uxa.1_5'Flank|ZNF174_uc002cva.2_Missense_Mutation_p.D123Y|ZNF174_uc002cvb.2_Missense_Mutation_p.D123Y	NM_003450	NP_003441	Q15697	ZN174_HUMAN	zinc finger protein 174 isoform a	123	SCAN box.				negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0						CCTCGTGGAAGATTTTCACAG	0.468													20	50					1.55795e-14	1.15003e-13	1	0	T	3452371	T	T	3452371	3	4	208	1	0	0	0	0	1	0	0	0	17811	942	33	2	369	2	ZNF174	16	3452371	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	1104592	3452371	86902382	89	38011											
NOD2	64127	broad.mit.edu	37	chr16	50745602	50745602	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgccaaaggtgtcgtgccaGggagtacggcgcccctggaa	8	6	16	11	3	0	0	0	0	0	0	1	2	0	2	4	4	3	1	4	4	3	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:50745602G>A	uc002egm.1	+	4	1885	c.1780G>A	c.(1780-1782)GGG>AGG	p.G594R	NOD2_uc010cbk.1_Missense_Mutation_p.G567R|NOD2_uc002egl.1_Missense_Mutation_p.G372R|NOD2_uc010cbl.1_Missense_Mutation_p.G372R|NOD2_uc010cbm.1_Missense_Mutation_p.G372R|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	594	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				TGTCGTGCCAGGGAGTACGGC	0.577													10	26					0	0	0	0	A	50745602	A	A	50745602	3	1	208	1	0	0	0	0	1	0	0	0	10571	1000	35	4	1794	4	NOD2	16	50745602	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	47293231	50745602	39609151	90	38012											
RBL2	5934	broad.mit.edu	37	chr16	53524139	53524139	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtgaatcacctgcaaaaaGaatttgcccagaaaatcatt	18	9	6	8	0	2	3	2	1	0	2	2	3	2	3	2	0	2	1	2	0	7	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:53524139G>C	uc002ehi.3	+	22	3465	c.3347G>C	c.(3346-3348)AGA>ACA	p.R1116T	RBL2_uc002ehj.2_Missense_Mutation_p.R826T|RBL2_uc010vgw.1_Missense_Mutation_p.R495T	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1116					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						CCTGCAAAAAGAATTTGCCCA	0.393													21	49					0	0	0	0	C	53524139	C	C	53524139	3	2	208	1	0	0	0	0	1	0	0	0	13175	942	33	2	3433	2	RBL2	16	53524139	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	2778537	53524139	36830614	91	38013											
SLC38A8	146167	broad.mit.edu	37	chr16	84065527	84065527	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccagaggtagtactgcaCggtgatgaccagggccaggt	9	6	17	9	1	0	3	0	2	0	1	0	3	0	3	3	5	2	3	3	5	2	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr16:84065527C>T	uc002fhg.1	-	4	577	c.577G>A	c.(577-579)GTG>ATG	p.V193M		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	193	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0						TAGTACTGCACGGTGATGACC	0.617													15	55					0	0	0	0	T	84065527	T	T	84065527	3	4	208	1	0	0	0	0	1	0	0	0	14674	536	19	1	758	1	SLC38A8	16	84065527	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	30541388	84065527	6289226	92	38014											
OR1E2	8388	broad.mit.edu	37	chr17	3336564	3336564	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccagcttcagcagagcaGacatatcacagaaaaagtgg	16	5	11	9	0	2	3	2	0	0	3	2	3	2	3	1	2	3	3	1	2	3	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:3336564G>T	uc010vre.1	-	1	572	c.572C>A	c.(571-573)TCT>TAT	p.S191Y		NM_003554	NP_003545	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E,	191	Extracellular (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			large_intestine(1)	1						CAGCAGAGCAGACATATCACA	0.468													18	27					4.75885e-15	3.53985e-14	1	0	T	3336564	T	T	3336564	3	4	208	1	0	0	0	0	1	0	0	0	11009	942	33	2	402	2	OR1E2	17	3336564	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08		3336564	77858646	93	38015											
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	6	8	16	11	2	1	1	1	1	0	0	2	3	2	2	4	5	2	2	4	5	0	1	rs121912651		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	44					0	0	0	0	A	7577539	A	A	7577539	3	1	208	1	0	0	0	0	1	0	0	0	16448	1115	39	1	548	1	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	4240975	7577539	73617671	94	38016											
PER1	5187	broad.mit.edu	37	chr17	8053316	8053316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcttgacacaggccagtgCgtactgcagcgtggccaggg	7	7	15	12	2	0	1	0	1	0	0	0	1	0	1	2	3	5	3	2	3	1	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:8053316C>T	uc002gkd.2	-	4	740	c.502G>A	c.(502-504)GCA>ACA	p.A168T	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Missense_Mutation_p.A152T|PER1_uc010vus.1_Missense_Mutation_p.A168T	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	168					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						CAGGCCAGTGCGTACTGCAGC	0.627			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					41	102					0	0	0	0	T	8053316	T	T	8053316	3	4	208	1	0	0	0	0	1	0	0	0	11783	768	27	1	3450	1	PER1	17	8053316	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	475777	8053316	73141894	95	38017											
TEKT3	64518	broad.mit.edu	37	chr17	15215733	15215733	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagcttagcggaagctgccCgttcactctgggagcggaga	8	9	14	10	3	2	1	1	0	1	1	2	4	2	3	1	3	5	3	1	3	3	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:15215733C>A	uc002gon.2	-	7	1131	c.944G>T	c.(943-945)CGG>CTG	p.R315L		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	315					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		GGAAGCTGCCCGTTCACTCTG	0.458													20	57					1.33834e-09	9.58646e-09	1	0	A	15215733	A	A	15215733	3	1	208	1	0	0	0	0	1	0	0	0	15820	652	23	3	540	3	TEKT3	17	15215733	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	7162417	15215733	65979477	96	38018											
TEKT3	64518	broad.mit.edu	37	chr17	15234646	15234646	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgtgaagaaagtggttctgTtggaaacaaagggaagcatg	14	10	14	3	0	1	2	0	1	1	1	1	4	1	4	0	3	2	3	0	3	5	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:15234646T>C	uc002gon.2	-	3	444	c.257A>G	c.(256-258)AAC>AGC	p.N86S		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	86					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		AGTGGTTCTGTTGGAAACAAA	0.478													31	67					0	0	0	0	C	15234646	C	C	15234646	3	2	208	1	0	0	0	0	1	0	0	0	15820	1725	60	5	1243	5	TEKT3	17	15234646	Missense_Mutation	SNP	T	TCGA-CV-6953-01A-11D-1912-08	18913	15234646	65960564	97	38019											
KRT37	8688	broad.mit.edu	37	chr17	39580482	39580482	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctcatggccattcagggtGtttttgccgtaggccccaca	6	13	10	12	1	2	0	2	0	1	0	3	0	2	0	4	3	1	2	4	3	1	5			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:39580482G>A	uc002hwp.1	-	1	341	c.294C>T	c.(292-294)AAC>AAT	p.N98N	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	98	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				CATTCAGGGTGTTTTTGCCGT	0.582													21	68					0	0	0	0	A	39580482	A	A	39580482	2	1	208	1	0	0	0	0	0	0	0	1	8513	1368	48	4		4	KRT37	17	39580482	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	24345836	39580482	41614728	98	38020											
KRT35	3886	broad.mit.edu	37	chr17	39635675	39635675	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccaggtcagacttgcacAgggtcaggtcatccaggatc	9	8	11	13	0	3	1	3	0	0	1	6	2	5	2	3	4	1	1	3	4	0	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:39635675A>C	uc002hws.2	-	3	678	c.635T>G	c.(634-636)CTG>CGG	p.L212R		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	212	Rod.|Coil 1B.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				AGACTTGCACAGGGTCAGGTC	0.517													18	82					0	0	0	0	C	39635675	C	C	39635675	3	2	208	1	0	0	0	0	1	0	0	0	8511	188	7	5	752	5	KRT35	17	39635675	Missense_Mutation	SNP	A	TCGA-CV-6953-01A-11D-1912-08	55193	39635675	41559535	99	38021											
WNT3	7473	broad.mit.edu	37	chr17	44845801	44845801	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctccgtcctcgtgttgtggCcccggccacagcagagcaga	6	8	12	15	3	1	2	0	0	1	2	4	2	2	2	5	2	2	3	5	2	0	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:44845801C>T	uc002ikv.2	-	4	1072	c.953G>A	c.(952-954)GGC>GAC	p.G318D		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	318					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			CGTGTTGTGGCCCCGGCCACA	0.592													31	117					0	0	0	0	T	44845801	T	T	44845801	3	4	208	1	0	0	0	0	1	0	0	0	17456	739	26	4	118	4	WNT3	17	44845801	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	5210126	44845801	36349409	100	38022											
QRICH2	84074	broad.mit.edu	37	chr17	74289852	74289852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcacgccagcttcatcaCgggccctcggctgctgctgt	4	9	13	15	3	2	0	2	0	0	0	3	0	2	0	2	3	3	5	2	3	0	1	rs138229886		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr17:74289852C>T	uc002jrd.1	-	4	638	c.458G>A	c.(457-459)CGT>CAT	p.R153H	QRICH2_uc010wsz.1_Missense_Mutation_p.R79H|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	153							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						AGCTTCATCACGGGCCCTCGG	0.542													14	50					0	0	0	0	T	74289852	T	T	74289852	3	4	208	1	0	0	0	0	1	0	0	0	12945	536	19	1	4597	1	QRICH2	17	74289852	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	29444051	74289852	6905358	101	38023											
ATP8B3	148229	broad.mit.edu	37	chr19	1796851	1796851	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagagcagcttcccgtcggCgaacttgttccagaggtagg	9	8	14	10	3	0	2	0	0	0	2	3	4	2	2	2	3	3	4	2	3	3	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:1796851C>T	uc002ltw.2	-	16	1846	c.1612G>A	c.(1612-1614)GCC>ACC	p.A538T	ATP8B3_uc002ltv.2_Missense_Mutation_p.A491T|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	538	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCCCGTCGGCGAACTTGTTC	0.721													7	20					0	0	0	0	T	1796851	T	T	1796851	3	4	208	1	0	0	0	0	1	0	0	0	1198	768	27	1	2376	1	ATP8B3	19	1796851	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08		1796851	57332132	102	38024											
PRKACA	5566	broad.mit.edu	37	chr19	14213716	14213716	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgtgttcgatctgtttcAgtttcaccacctgggaaggg	6	13	14	8	1	3	0	2	0	1	0	4	2	3	1	2	3	0	3	2	3	1	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:14213716A>G	uc002myc.2	-	4	448	c.248T>C	c.(247-249)CTG>CCG	p.L83P	PRKACA_uc002myb.2_Missense_Mutation_p.L75P|PRKACA_uc010xnm.1_Missense_Mutation_p.L25P|PRKACA_uc002myd.2_Missense_Mutation_p.L25P	NM_002730	NP_002721	P17612	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit	83	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1						GATCTGTTTCAGTTTCACCAC	0.562													23	81					0	0	0	0	G	14213716	G	G	14213716	3	3	208	1	0	0	0	0	1	0	0	0	12559	188	7	5	835	5	PRKACA	19	14213716	Missense_Mutation	SNP	A	TCGA-CV-6953-01A-11D-1912-08	12416865	14213716	44915267	103	38025											
CYP4F12	66002	broad.mit.edu	37	chr19	15806808	15806808	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggagagcctgaggttacatcCcccagctcccttcatctccc	7	9	8	17	0	2	2	1	1	1	1	5	3	4	2	5	2	3	2	5	2	1	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:15806808C>T	uc002nbl.2	+	10	1239	c.1178C>T	c.(1177-1179)CCC>CTC	p.P393L		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					AGGTTACATCCCCCAGCTCCC	0.597													27	61					0	0	0	0	T	15806808	T	T	15806808	3	4	208	1	0	0	0	0	1	0	0	0	4204	623	22	4	1212	4	CYP4F12	19	15806808	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	1593092	15806808	43322175	104	38026											
ZNF208	7757	broad.mit.edu	37	chr19	22156897	22156897	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgccacattctttacatttGtagggcttctctccagcatg	7	16	7	11	0	2	0	0	0	2	0	4	0	3	0	2	1	3	3	2	1	2	7			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:22156897G>T	uc002nqp.2	-	4	1088	c.939C>A	c.(937-939)TAC>TAA	p.Y313*	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTTTACATTTGTAGGGCTTCT	0.418													9	48					2.17888e-05	0.000148378	1	0	T	22156897	T	T	22156897	4	4	208	1	0	0	0	0	0	1	0	0	17833	1372	48	4	2907	4	ZNF208	19	22156897	Nonsense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	6350089	22156897	36972086	105	38027											
SLC7A9	11136	broad.mit.edu	37	chr19	33334841	33334841	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcatgtgaccctcccggcCcgccacgtaaatgagtctgg	8	7	12	14	3	1	2	0	2	1	0	2	3	2	2	4	2	1	2	4	2	2	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:33334841C>T	uc002ntv.3	-	10	1111	c.994G>A	c.(994-996)GGC>AGC	p.G332S	SLC7A9_uc002ntt.3_Intron|SLC7A9_uc002ntu.3_Missense_Mutation_p.G332S|SLC7A9_uc002ntw.3_Missense_Mutation_p.G123S	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	332	Cytoplasmic (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	CCCTCCCGGCCCGCCACGTAA	0.567													7	28					0	0	0	0	T	33334841	T	T	33334841	3	4	208	1	0	0	0	0	1	0	0	0	14769	623	22	4	485	4	SLC7A9	19	33334841	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	11177944	33334841	25794142	106	38028											
KIAA0355	9710	broad.mit.edu	37	chr19	34791871	34791871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattcagtctccaggacattGaggtagagtatcttttgtgt	10	15	10	6	0	3	2	1	1	2	1	4	3	3	3	1	2	0	2	1	2	3	6			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:34791871G>A	uc002nvd.3	+	2	1352	c.493G>A	c.(493-495)GAG>AAG	p.E165K	KIAA0355_uc010edk.1_Missense_Mutation_p.E155K	NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	165										ovary(1)	1	Esophageal squamous(110;0.162)					CCAGGACATTGAGGTAGAGTA	0.393													10	43					0	0	0	0	A	34791871	A	A	34791871	3	1	208	1	0	0	0	0	1	0	0	0	8209	1291	45	2	495	2	KIAA0355	19	34791871	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	1457030	34791871	24337112	107	38029											
HNRNPL	3191	broad.mit.edu	37	chr19	39334716	39334716	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccattgagagaggccttggCccgctgggcactttgaactg	7	9	13	12	1	0	3	0	2	0	1	0	4	0	3	3	3	1	2	3	3	1	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:39334716C>G	uc010xul.1	-	5	750	c.739G>C	c.(739-741)GCC>CCC	p.A247P	HNRNPL_uc002ojk.2_5'Flank|HNRNPL_uc002ojl.2_5'Flank|HNRNPL_uc010xum.1_Missense_Mutation_p.A114P|HNRNPL_uc010xun.1_5'UTR	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	247	RRM 2.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			GAGGCCTTGGCCCGCTGGGCA	0.493													20	65					0	0	0	0	G	39334716	G	G	39334716	3	3	208	1	0	0	0	0	1	0	0	0	7309	739	26	4	1066	4	HNRNPL	19	39334716	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	4542845	39334716	19794267	108	38030											
PSG1	5669	broad.mit.edu	37	chr19	43382154	43382155	+	Missense_Mutation	DNP	CG	AT	AT																															tgtaggatcctgcgtcctccCgggtgacattctggatcagc																								rs142473373		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:43382154_43382155CG>AT	uc002ovb.2	-	2	478_479	c.340_341CG>AT	c.(340-342)CGG>ATG	p.R114M	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.R114M|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.R114M|PSG1_uc010eio.1_Missense_Mutation_p.R114M|PSG1_uc002oux.1_Missense_Mutation_p.R43M|PSG1_uc002ouy.1_Missense_Mutation_p.R114M|PSG1_uc002ouz.1_Missense_Mutation_p.R114M|PSG1_uc002ova.1_Missense_Mutation_p.R114M|PSG1_uc002ovc.2_Missense_Mutation_p.R114M|PSG1_uc002ovd.1_Missense_Mutation_p.R114M	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	114	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TGCGTCCTCCCGGGTGACATTC	0.45													9	397					0	0	0	0	AT	43382155	AT	AT	43382154	3	1	208	1	0	0	0	0	1	0	0	0	12715	652	23	3	991	3	PSG1	19	43382154	Missense_Mutation	DNP	CG	TCGA-CV-6953-01A-11D-1912-08	4047438	43382154	15746829	109	38031											
PRR12	57479	broad.mit.edu	37	chr19	50102549	50102549	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaagctgtctgtgcccaaGgctggcgagggtctgggaac	8	8	15	10	1	3	0	1	0	2	0	3	2	3	1	1	4	3	2	1	4	3	0			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:50102549G>A	uc002poo.3	+	5	3699	c.3699G>A	c.(3697-3699)AAG>AAA	p.K1233K		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	412	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CTGTGCCCAAGGCTGGCGAGG	0.617													6	22					0	0	0	0	A	50102549	A	A	50102549	2	1	208	1	0	0	0	0	0	0	0	1	12646	991	35	4		4	PRR12	19	50102549	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	6720395	50102549	9026434	110	38032											
USP29	57663	broad.mit.edu	37	chr19	57642405	57642405	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgaatcaccttggggcactgGgttctgacaacccaggaaac	11	8	11	11	0	2	2	1	2	1	0	2	3	2	3	2	4	2	2	2	4	3	2	rs148519716		TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr19:57642405G>T	uc002qny.2	+	4	2718	c.2362G>T	c.(2362-2364)GGT>TGT	p.G788C		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	788					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGGGGCACTGGGTTCTGACAA	0.458													14	31					3.27435e-08	2.31117e-07	1	0	T	57642405	T	T	57642405	3	4	208	1	0	0	0	0	1	0	0	0	17127	1232	43	4	2364	4	USP29	19	57642405	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	7539856	57642405	1486578	111	38033											
SLC4A11	83959	broad.mit.edu	37	chr20	3208447	3208447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgccagtcaaggcctgtgctCagcgtccatgacatccaagt	9	9	10	13	1	2	1	2	1	0	0	4	1	4	1	4	1	3	1	4	1	2	0			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr20:3208447C>T	uc002wig.2	-	19	2710	c.2662G>A	c.(2662-2664)GAG>AAG	p.E888K	SLC4A11_uc010zqe.1_Missense_Mutation_p.E915K|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.E872K	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	888	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						GGCCTGTGCTCAGCGTCCATG	0.612													11	38					0	0	0	0	T	3208447	T	T	3208447	3	4	208	1	0	0	0	0	1	0	0	0	14716	835	29	2	17	2	SLC4A11	20	3208447	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08		3208447	59817073	112	38034											
PMEPA1	56937	broad.mit.edu	37	chr20	56285620	56285620	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacccgaacccaaggaggaCgaccaggaaagacgggaact	15	2	12	12	3	1	1	1	0	0	1	1	7	1	5	3	4	2	0	3	4	4	0			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr20:56285620C>T	uc002xyq.2	-						PMEPA1_uc002xyr.2_5'UTR|PMEPA1_uc002xys.2_5'UTR|PMEPA1_uc002xyt.2_Intron|uc002xyu.1_RNA	NM_020182	NP_064567	Q969W9	PMEPA_HUMAN	transmembrane prostate androgen-induced protein						androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			pancreas(1)	1						CCAAGGAGGACGACCAGGAAA	0.617													3	4					0	0	0	0	T	56285620	T	T	56285620	1	4	208	0	1	0	0	0	0	0	0	0	12187	551	19	1		1	PMEPA1	20	56285620	5'Flank	SNP	C	TCGA-CV-6953-01A-11D-1912-08	53077173	56285620	6739900	113	38035											
MYH9	4627	broad.mit.edu	37	chr22	36688143	36688144	+	Missense_Mutation	DNP	CA	AG	AG																															agccgcgtcttggtcttctcCagcttgtcgtaggcggccac																										TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr22:36688143_36688144CA>AG	uc003apg.2	-	31	4463_4464	c.4232_4233TG>CT	c.(4231-4233)CTG>CCT	p.L1411P		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1411	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGGTCTTCTCCAGCTTGTCGTA	0.634			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				9	75					0	0	0	0	AG	36688144	AG	AG	36688143	3	1	208	1	0	0	0	0	1	0	0	0	10095	581	21	4	1693	4	MYH9	22	36688143	Missense_Mutation	DNP	CA	TCGA-CV-6953-01A-11D-1912-08		36688143	14616423	114	38036											
CACNG2	10369	broad.mit.edu	37	chr22	37098538	37098538	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagagccaatagtcggttccCacagctatggtcatcaggct	10	10	10	11	1	2	1	2	0	0	1	4	1	3	1	2	3	2	3	2	3	4	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr22:37098538C>A	uc003aps.1	-	1	366	c.84G>T	c.(82-84)GTG>GTT	p.V28V	uc003apt.1_5'Flank	NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	28	Helical; (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						AGTCGGTTCCCACAGCTATGG	0.453													43	146					1.22102e-19	9.2244e-19	1	0	A	37098538	A	A	37098538	2	1	208	1	0	0	0	0	0	0	0	1	2569	581	21	4		4	CACNG2	22	37098538	Silent	SNP	C	TCGA-CV-6953-01A-11D-1912-08	410395	37098538	14206028	115	38037											
MEI1	150365	broad.mit.edu	37	chr22	42189908	42189908	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctggatgcccggagcccaGacattggtagaaactctcca	11	7	10	13	1	1	2	0	0	1	2	2	4	1	4	4	3	3	1	4	3	2	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chr22:42189908G>C	uc003baz.1	+	27	3446	c.3421G>C	c.(3421-3423)GAC>CAC	p.D1141H	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Missense_Mutation_p.D527H|MEI1_uc003bbc.1_Missense_Mutation_p.D509H|MEI1_uc010gym.1_Missense_Mutation_p.D474H|MEI1_uc003bbd.1_Missense_Mutation_p.D384H|MEI1_uc010gyn.1_RNA|MEI1_uc003bbe.1_RNA|MEI1_uc011apf.1_Missense_Mutation_p.D155H|MEI1_uc010gyo.1_3'UTR|MEI1_uc003bbf.2_Missense_Mutation_p.D155H|MEI1_uc003bbg.2_Missense_Mutation_p.D155H	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	1141							binding			central_nervous_system(1)|skin(1)	2						CCGGAGCCCAGACATTGGTAG	0.498													5	13					0	0	0	0	C	42189908	C	C	42189908	3	2	208	1	0	0	0	0	1	0	0	0	9518	942	33	2	3527	2	MEI1	22	42189908	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	5091370	42189908	9114658	116	38038											
RS1	6247	broad.mit.edu	37	chrX	18662590	18662590	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtagtaaatccagttcAggcgctcatcggtcctgtac	8	12	9	12	2	2	0	2	0	0	0	5	0	4	0	3	2	1	5	3	2	4	5			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:18662590A>C	uc004cyo.2	-	5	517	c.482T>G	c.(481-483)CTG>CGG	p.L161R	CDKL5_uc004cym.2_Intron|CDKL5_uc004cyn.2_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein	161	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					AATCCAGTTCAGGCGCTCATC	0.532													6	95					0	0	0	0	C	18662590	C	C	18662590	3	2	208	1	0	0	0	0	1	0	0	0	13758	188	7	5	200	5	RS1	23	18662590	Missense_Mutation	SNP	A	TCGA-CV-6953-01A-11D-1912-08		18662590	136607970	117	38039											
FAM47A	158724	broad.mit.edu	37	chrX	34149003	34149003	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggaggctgcaggcagggttCcccacaaggggatttatgag	9	7	17	8	0	0	1	0	1	0	0	1	3	1	3	2	6	1	4	2	6	2	3			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:34149003C>T	uc004ddg.2	-	1	1426	c.1393G>A	c.(1393-1395)GAA>AAA	p.E465K		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	465										ovary(4)|central_nervous_system(1)	5						AGGCAGGGTTCCCCACAAGGG	0.602													13	45					0	0	0	0	T	34149003	T	T	34149003	3	4	208	1	0	0	0	0	1	0	0	0	5601	864	30	2	986	2	FAM47A	23	34149003	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	15486413	34149003	121121557	118	38040											
MED12	9968	broad.mit.edu	37	chrX	70342193	70342193	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtaacagtgccttcactcaGcaggtatgtctgaccactag	10	10	10	11	0	3	1	2	1	1	0	3	1	3	1	2	2	3	3	2	2	3	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:70342193G>A	uc004dyy.2	+	8	1444	c.1245G>A	c.(1243-1245)CAG>CAA	p.Q415Q	MED12_uc011mpq.1_Silent_p.Q415Q|MED12_uc004dyz.2_Silent_p.Q415Q|MED12_uc004dza.2_Silent_p.Q262Q	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	415					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CCTTCACTCAGCAGGTATGTC	0.483													17	39					0	0	0	0	A	70342193	A	A	70342193	2	1	208	1	0	0	0	0	0	0	0	1	9481	962	34	4		4	MED12	23	70342193	Silent	SNP	G	TCGA-CV-6953-01A-11D-1912-08	36193190	70342193	84928367	119	38041											
NRK	203447	broad.mit.edu	37	chrX	105183934	105183934	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agattttgaataatgatccaGaaagtaaaagaaggcaagaa	21	8	9	3	0	0	6	0	2	0	4	1	6	1	6	1	1	0	2	1	1	8	4			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:105183934G>A	uc004emd.2	+	23	4171	c.3868G>A	c.(3868-3870)GAA>AAA	p.E1290K	NRK_uc010npc.1_Missense_Mutation_p.E958K	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1290	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TAATGATCCAGAAAGTAAAAG	0.378										HNSCC(51;0.14)			4	14					0	0	0	0	A	105183934	A	A	105183934	3	1	208	1	0	0	0	0	1	0	0	0	10709	943	33	2	3958	2	NRK	23	105183934	Missense_Mutation	SNP	G	TCGA-CV-6953-01A-11D-1912-08	34841741	105183934	50086626	120	38042											
IRS4	8471	broad.mit.edu	37	chrX	107979141	107979141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtatagggtgatcacgcgcCgcggtggaatgagcgggggg	7	6	21	7	5	1	2	1	2	0	0	1	3	1	3	1	7	1	1	1	7	3	2			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:107979141C>T	uc004eoc.2	-	1	467	c.434G>A	c.(433-435)CGG>CAG	p.R145Q		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	145	PH.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GATCACGCGCCGCGGTGGAAT	0.632													7	35					0	0	0	0	T	107979141	T	T	107979141	3	4	208	1	0	0	0	0	1	0	0	0	7881	652	23	1	3343	1	IRS4	23	107979141	Missense_Mutation	SNP	C	TCGA-CV-6953-01A-11D-1912-08	2795207	107979141	47291419	121	38043											
TMEM187	8269	broad.mit.edu	37	chrX	153247752	153247752	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggggcggcgcgatggggcTgggtccccgctacctgaagg	5	5	19	12	4	0	1	0	1	0	0	1	2	1	1	3	7	1	2	3	7	2	1			TCGA-CV-6953-01A-11D-1912-08	TCGA-CV-6953-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fb79f2be-3dec-4b5a-b5f3-e29e0fb05a98	a4236b26-0102-4650-b659-45cb5f0a61d9	g.chrX:153247752T>C	uc004fjq.2	+	2	773	c.239T>C	c.(238-240)CTG>CCG	p.L80P	hsa-mir-3202-2|MI0014253_5'Flank	NM_003492	NP_003483	Q14656	TM187_HUMAN	transmembrane protein 187	80						integral to membrane|transport vesicle					0	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCGATGGGGCTGGGTCCCCGC	0.692													7	24					0	0	0	0	C	153247752	C	C	153247752	3	2	208	1	0	0	0	0	1	0	0	0	16175	1580	55	5	241	5	TMEM187	23	153247752	Missense_Mutation	SNP	T	TCGA-CV-6953-01A-11D-1912-08	45268611	153247752	2022808	122	38044											
TPRG1L	127262	broad.mit.edu	37	chr1	3544105	3544105	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcagtgggacaagcaaaGtcgtccttccttcataaaca	14	10	7	10	1	2	0	2	0	0	0	5	1	4	1	2	1	2	1	2	1	5	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:3544105G>T	uc001akm.2	+	4	593	c.512G>T	c.(511-513)AGT>ATT	p.S171I	TPRG1L_uc009vlj.2_Missense_Mutation_p.S112I	NM_182752	NP_877429	Q5T0D9	TPRGL_HUMAN	tumor protein p63 regulated 1-like	171						cell junction|synaptic vesicle					0	all_cancers(77;0.0119)|all_epithelial(69;0.00481)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.41e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.83e-22)|GBM - Glioblastoma multiforme(42;4.77e-14)|Colorectal(212;1.12e-05)|COAD - Colon adenocarcinoma(227;5.61e-05)|Kidney(185;0.000351)|BRCA - Breast invasive adenocarcinoma(365;0.000688)|KIRC - Kidney renal clear cell carcinoma(229;0.00553)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.201)		GACAAGCAAAGTCGTCCTTCC	0.502													11	221					1.33987e-11	1.68751e-11	1	0	T	3544105	T	T	3544105	3	4	209	1	0	0	0	0	1	0	0	0	16486	1029	36	4	526	4	TPRG1L	1	3544105	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08		3544105	245706516	1	38045											
DDI2	84301	broad.mit.edu	37	chr1	15959965	15959965	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagtcctggtggagcagcaGcaggaccgagcccggagaga	11	3	17	10	2	0	2	0	0	0	2	1	7	1	5	3	4	4	3	3	4	0	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:15959965G>A	uc001awx.1	+	4	633	c.537G>A	c.(535-537)CAG>CAA	p.Q179Q	DDI2_uc001aww.2_Silent_p.Q179Q|DDI2_uc009voj.1_5'UTR	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	179					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TGGAGCAGCAGCAGGACCGAG	0.398													5	322					0	0	0	0	A	15959965	A	A	15959965	2	1	209	1	0	0	0	0	0	0	0	1	4346	962	34	4		4	DDI2	1	15959965	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	12415860	15959965	233290656	2	38046											
GRHL3	57822	broad.mit.edu	37	chr1	24669194	24669194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcccctgcagggagctgagaGgaagatgcgcgatgacgagc	10	5	16	10	3	0	3	0	2	0	2	1	8	1	5	2	2	4	2	2	2	1	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:24669194G>A	uc001biy.2	+	10	1278	c.1232G>A	c.(1231-1233)AGG>AAG	p.R411K	GRHL3_uc001bix.2_Missense_Mutation_p.R406K|GRHL3_uc001biz.2_Missense_Mutation_p.R313K	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	406					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GGAGCTGAGAGGAAGATGCGC	0.597													5	126					0	0	0	0	A	24669194	A	A	24669194	3	1	209	1	0	0	0	0	1	0	0	0	6804	1000	35	4	1291	4	GRHL3	1	24669194	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	8709229	24669194	224581427	3	38047											
SYNC	81493	broad.mit.edu	37	chr1	33149862	33149862	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagcagcagaaactgacttaTaagtagagagctcttcagca	15	9	9	8	0	2	3	1	1	1	2	2	4	2	3	0	0	5	5	0	0	5	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:33149862T>C	uc001bvt.2	-	3	1455	c.1355A>G	c.(1354-1356)TAT>TGT	p.Y452C	SYNC_uc010ohl.1_Missense_Mutation_p.Y452C|RBBP4_uc001bvr.2_3'UTR|RBBP4_uc001bvs.2_3'UTR|RBBP4_uc010ohj.1_3'UTR|RBBP4_uc010ohk.1_3'UTR	NM_030786	NP_110413	Q9H7C4	SYNCI_HUMAN	syncoilin, intermediate filament 1 isoform 1	452	Coil 2.					intermediate filament|perinuclear region of cytoplasm	structural molecule activity			ovary(1)	1						AACTGACTTATAAGTAGAGAG	0.433													139	187					0	0	0	0	C	33149862	C	C	33149862	3	2	209	1	0	0	0	0	1	0	0	0	15509	1406	49	5	167	5	SYNC	1	33149862	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	8480668	33149862	216100759	4	38048											
MACF1	23499	broad.mit.edu	37	chr1	39844998	39844998	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaatggaggaggttcacaAggaggcaaactctgtgctgc	12	7	14	8	0	2	1	1	0	1	1	2	4	2	4	0	5	3	3	0	5	3	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:39844998A>T	uc010oiu.1	+	18	8851	c.8720A>T	c.(8719-8721)AAG>ATG	p.K2907M	MACF1_uc010ois.1_Missense_Mutation_p.K2405M|MACF1_uc001cda.1_Missense_Mutation_p.K2292M|MACF1_uc001cdc.1_Missense_Mutation_p.K1471M	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4472	Spectrin 3.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAGGTTCACAAGGAGGCAAAC	0.468													7	286					0	0	0	0	T	39844998	T	T	39844998	3	4	209	1	0	0	0	0	1	0	0	0	9195	72	3	5	13559	5	MACF1	1	39844998	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	6695136	39844998	209405623	5	38049											
HPDL	84842	broad.mit.edu	37	chr1	45792887	45792887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccgggcagcccctagccCggaacctgcagcgcctcttc	5	5	11	20	4	1	0	0	0	1	0	2	1	1	1	7	2	5	2	7	2	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:45792887C>T	uc001cne.2	+	1	343	c.67C>T	c.(67-69)CGG>TGG	p.R23W		NM_032756	NP_116145	Q96IR7	HPDL_HUMAN	glyoxalase domain containing 1	23					aromatic amino acid family metabolic process		4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	Acute lymphoblastic leukemia(166;0.155)					GCCCCTAGCCCGGAACCTGCA	0.697													14	19					0	0	0	0	T	45792887	T	T	45792887	3	4	209	1	0	0	0	0	1	0	0	0	7372	643	23	1	69	1	HPDL	1	45792887	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	5947889	45792887	203457734	6	38050											
ROR1	4919	broad.mit.edu	37	chr1	64643163	64643163	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acgctttatggaagaattggGtgagtgtgcctttggaaaaa	12	12	13	4	1	0	2	0	1	0	1	0	4	0	4	1	3	1	1	1	3	5	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:64643163G>A	uc001dbj.2	+	9	1838	c.1439G>A	c.(1438-1440)GGT>GAT	p.G480D	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	480	ATP (By similarity).|Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						GAAGAATTGGGTGAGTGTGCC	0.423													21	270					0	0	0	0	A	64643163	A	A	64643163	3	1	209	1	0	0	0	0	1	0	0	0	13591	1261	44	4	1481	4	ROR1	1	64643163	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	18850276	64643163	184607458	7	38051											
LEPR	3953	broad.mit.edu	37	chr1	66074565	66074565	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gattcgctatggtttaagtgGaaaagaagtacaatggaagg	15	10	13	3	1	0	1	0	0	0	1	1	4	0	3	0	4	1	3	0	4	8	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:66074565G>T	uc001dci.2	+	12	1935	c.1733G>T	c.(1732-1734)GGA>GTA	p.G578V	LEPR_uc001dcg.2_Missense_Mutation_p.G578V|LEPR_uc001dch.2_Missense_Mutation_p.G578V|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.G578V|LEPR_uc001dck.2_Missense_Mutation_p.G578V	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	578	Extracellular (Potential).|Fibronectin type-III 2.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GGTTTAAGTGGAAAAGAAGTA	0.303													16	28					1.33834e-09	1.65868e-09	1	0	T	66074565	T	T	66074565	3	4	209	1	0	0	0	0	1	0	0	0	8768	1174	41	2	1771	2	LEPR	1	66074565	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	1431402	66074565	183176056	8	38052											
CLCA2	9635	broad.mit.edu	37	chr1	86904619	86904619	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttgatgcagattgttgaaAttcataccttcgtgggcatt	10	16	9	6	1	1	3	1	2	0	1	2	3	1	3	1	1	2	3	1	1	2	7			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:86904619A>T	uc001dlr.3	+	7	1195	c.1033A>T	c.(1033-1035)ATT>TTT	p.I345F		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	345	VWFA.|Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		GATTGTTGAAATTCATACCTT	0.418													6	73					0	0	0	0	T	86904619	T	T	86904619	3	4	209	1	0	0	0	0	1	0	0	0	3473	101	4	5	1059	5	CLCA2	1	86904619	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	20830054	86904619	162346002	9	38053											
HS2ST1	9653	broad.mit.edu	37	chr1	87558326	87558326	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgattatagaccagggttaCggagacgaaaacaaggagac	17	6	12	6	2	0	4	0	1	0	3	0	7	0	4	1	3	2	1	1	3	6	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:87558326C>T	uc010osk.1	+	4	947	c.562C>T	c.(562-564)CGG>TGG	p.R188W	HS2ST1_uc001dmc.3_Missense_Mutation_p.R188W|LOC339524_uc001dme.1_Missense_Mutation_p.R149W	NM_012262	NP_036394	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1 isoform	188	Lumenal (Potential).					Golgi membrane|integral to membrane				central_nervous_system(1)	1		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		ACCAGGGTTACGGAGACGAAA	0.303													5	29					0	0	0	0	T	87558326	T	T	87558326	3	4	209	1	0	0	0	0	1	0	0	0	7401	527	19	1	576	1	HS2ST1	1	87558326	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	653707	87558326	161692295	10	38054											
VAV3	10451	broad.mit.edu	37	chr1	108307728	108307728	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtttgacatcttcttttgtCttagaaatgtagtctaaact	11	18	6	6	0	4	2	0	1	4	1	4	2	4	2	0	0	1	2	0	0	5	7			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:108307728C>T	uc001dvk.1	-	9	945	c.891G>A	c.(889-891)AAG>AAA	p.K297K	VAV3_uc010ouw.1_Silent_p.K297K|VAV3_uc001dvl.1_Silent_p.K121K|VAV3_uc010oux.1_Silent_p.K297K	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	297	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CTTCTTTTGTCTTAGAAATGT	0.338													6	41					0	0	0	0	T	108307728	T	T	108307728	2	4	209	1	0	0	0	0	0	0	0	1	17201	912	32	2		2	VAV3	1	108307728	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	20749402	108307728	140942893	11	38055											
LOC200030	200030	broad.mit.edu	37	chr1	148342511	148342511	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actttctcagcctcctcaacTtgaacatcttcatcctcatc	9	14	2	16	0	5	1	4	1	2	0	9	1	7	1	3	0	3	0	3	0	2	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:148342511T>G	uc001eqf.2	-	4	560	c.525A>C	c.(523-525)CAA>CAC	p.Q175H	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqg.2_Intron|NBPF14_uc009wkf.1_Intron|uc001erd.3_Missense_Mutation_p.Q175H|uc001erc.3_RNA|uc010paj.1_Intron|uc010pau.1_5'Flank|uc010pav.1_Missense_Mutation_p.Q175H|uc010paw.1_Missense_Mutation_p.Q100H	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	175	NBPF 1.					cytoplasm					0						CCTCCTCAACTTGAACATCTT	0.418													56	499					0	0	0	0	G	148342511	G	G	148342511	3	3	209	1	0	0	0	0	1	0	0	0	8917	1624	56	5		5	LOC200030	1	148342511	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	40034783	148342511	100908110	12	38056											
HIST2H2AB	317772	broad.mit.edu	37	chr1	149859412	149859412	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggagaccagcgcgggacgAgcgcgacttggccttagcgc	7	5	16	13	6	0	1	0	0	0	1	0	5	0	2	2	3	3	0	2	3	1	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:149859412A>T	uc001ete.2	-	1	55	c.55T>A	c.(55-57)TCG>ACG	p.S19T	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	19					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GCGCGGGACGAGCGCGACTTG	0.622													5	90					0	0	0	0	T	149859412	T	T	149859412	3	4	209	1	0	0	0	0	1	0	0	0	7216	304	11	5	341	5	HIST2H2AB	1	149859412	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	1516901	149859412	99391209	13	38057											
FCRL4	83417	broad.mit.edu	37	chr1	157557209	157557209	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctccagtctgacaggatgAcctcgccatctctgaagaag	10	9	10	12	1	2	4	0	3	2	1	5	5	3	5	3	1	1	1	3	1	2	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:157557209A>G	uc001fqw.2	-	5	840	c.704T>C	c.(703-705)GTC>GCC	p.V235A	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	235	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				TGACAGGATGACCTCGCCATC	0.532													24	289					0	0	0	0	G	157557209	G	G	157557209	3	3	209	1	0	0	0	0	1	0	0	0	5829	275	10	5	875	5	FCRL4	1	157557209	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	7697797	157557209	91693412	14	38058											
TBX19	9095	broad.mit.edu	37	chr1	168274253	168274253	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtctattttagtgggaggCtggatcttttccaatccaga	8	16	10	7	0	2	1	0	0	2	1	4	3	4	3	2	3	0	1	2	3	3	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:168274253C>A	uc001gfl.2	+	6	786	c.735C>A	c.(733-735)GGC>GGA	p.G245G	TBX19_uc001gfj.3_Intron|TBX19_uc001gfm.2_Translation_Start_Site	NM_005149	NP_005140	O60806	TBX19_HUMAN	T-box 19	245					anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)					TAGTGGGAGGCTGGATCTTTT	0.493													16	73					2.94398e-08	3.61025e-08	1	0	A	168274253	A	A	168274253	2	1	209	1	0	0	0	0	0	0	0	1	15720	784	28	4		4	TBX19	1	168274253	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	10717044	168274253	80976368	15	38059											
KCNT2	343450	broad.mit.edu	37	chr1	196227581	196227581	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcccttgttctttggagTctttggtgtcttcccactct	2	18	10	11	0	4	0	0	0	4	0	5	1	5	1	2	3	1	1	2	3	0	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:196227581T>A	uc001gtd.1	-	26	3014	c.2954A>T	c.(2953-2955)GAC>GTC	p.D985V	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.D918V|KCNT2_uc001gtf.1_Missense_Mutation_p.D961V|KCNT2_uc001gtg.1_RNA|KCNT2_uc001gth.1_Missense_Mutation_p.D489V	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	985	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TTCTTTGGAGTCTTTGGTGTC	0.433													10	78					0	0	0	0	A	196227581	A	A	196227581	3	1	209	1	0	0	0	0	1	0	0	0	8131	1667	58	5	465	5	KCNT2	1	196227581	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	27953328	196227581	53023040	16	38060											
CFHR2	3080	broad.mit.edu	37	chr1	196927141	196927141	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgccagaacttgtatcaacTtgagggtaacaatcaaataa	16	10	8	7	0	2	2	2	1	0	1	2	2	2	2	1	1	4	2	1	1	7	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:196927141T>C	uc001gtq.1	+	4	628	c.551T>C	c.(550-552)CTT>CCT	p.L184P	CFHR2_uc001gtr.1_Missense_Mutation_p.L60P	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	184	Sushi 3.					extracellular region				skin(2)|ovary(1)	3						TTGTATCAACTTGAGGGTAAC	0.398													3	74					0	0	0	0	C	196927141	C	C	196927141	3	2	209	1	0	0	0	0	1	0	0	0	3300	1609	56	5	565	5	CFHR2	1	196927141	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	699560	196927141	52323480	17	38061											
RPS6KC1	26750	broad.mit.edu	37	chr1	213277842	213277842	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagagaagacaatgtgctgaAgacctgctacagttctctgc	12	9	11	9	0	1	4	0	1	1	3	2	6	1	4	1	0	4	3	1	0	4	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:213277842A>T	uc010ptr.1	+	4	468	c.309A>T	c.(307-309)GAA>GAT	p.E103D	RPS6KC1_uc001hkd.2_Missense_Mutation_p.E91D|RPS6KC1_uc010pts.1_Translation_Start_Site|RPS6KC1_uc010ptt.1_Translation_Start_Site|RPS6KC1_uc010ptu.1_Translation_Start_Site|RPS6KC1_uc010ptv.1_Translation_Start_Site|RPS6KC1_uc001hke.2_Translation_Start_Site	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	103	PX.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		AATGTGCTGAAGACCTGCTAC	0.353													4	59					0	0	0	0	T	213277842	T	T	213277842	3	4	209	1	0	0	0	0	1	0	0	0	13723	69	3	5	323	5	RPS6KC1	1	213277842	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	16350701	213277842	35972779	18	38062											
MIA3	375056	broad.mit.edu	37	chr1	222802470	222802470	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctagattctcctctccagaTgagattgatttgcccagaga	10	12	8	11	0	2	5	0	2	2	4	4	7	2	5	4	0	1	0	4	0	1	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:222802470T>A	uc001hnl.2	+	4	1917	c.1908T>A	c.(1906-1908)GAT>GAA	p.D636E	MIA3_uc009xea.1_Missense_Mutation_p.D472E	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	636	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		CCTCTCCAGATGAGATTGATT	0.468													35	158					0	0	0	0	A	222802470	A	A	222802470	3	1	209	1	0	0	0	0	1	0	0	0	9618	1461	51	5	1922	5	MIA3	1	222802470	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	9524628	222802470	26448151	19	38063											
NUP133	55746	broad.mit.edu	37	chr1	229637829	229637829	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatccaccttcatctatgtTaatggtcagctggtcatcga	9	13	7	12	1	4	0	3	0	1	0	6	1	5	0	3	2	1	2	3	2	2	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:229637829T>C	uc001htn.2	-	3	414	c.322A>G	c.(322-324)AAC>GAC	p.N108D		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	108					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				TCATCTATGTTAATGGTCAGC	0.363													8	113					0	0	0	0	C	229637829	C	C	229637829	3	2	209	1	0	0	0	0	1	0	0	0	10808	1754	61	5	3244	5	NUP133	1	229637829	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	6835359	229637829	19612792	20	38064											
LYST	1130	broad.mit.edu	37	chr1	235827826	235827826	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatactccctcaggctggtTggagaaagccacggaacaga	13	6	12	10	1	1	3	1	0	0	3	2	5	2	4	2	4	3	2	2	4	3	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:235827826T>C	uc001hxj.2	-	51	11309	c.11134A>G	c.(11134-11136)AAC>GAC	p.N3712D	LYST_uc001hxi.2_Missense_Mutation_p.N936D	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3712	WD 6.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCAGGCTGGTTGGAGAAAGCC	0.468									Chediak-Higashi_syndrome				4	58					0	0	0	0	C	235827826	C	C	235827826	3	2	209	1	0	0	0	0	1	0	0	0	9179	1812	63	5	283	5	LYST	1	235827826	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	6189997	235827826	13422795	21	38065											
OR2G3	81469	broad.mit.edu	37	chr1	247769355	247769355	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcagtggtttggctagttcCctaatccatgcaacttttac	8	15	7	11	0	1	0	1	0	0	0	3	0	3	0	2	2	3	4	2	2	4	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr1:247769355C>T	uc010pyz.1	+	1	468	c.468C>T	c.(466-468)TCC>TCT	p.S156S		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGGCTAGTTCCCTAATCCATG	0.483													4	139					0	0	0	0	T	247769355	T	T	247769355	2	4	209	1	0	0	0	0	0	0	0	1	11053	610	22	4		4	OR2G3	1	247769355	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	11941529	247769355	1481266	22	38066											
ITSN2	50618	broad.mit.edu	37	chr2	24498605	24498606	+	Frame_Shift_Ins	INS	-	T	T																															cagcctcatcttctagtttcINStttttctgcattagttctaa																										TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:24498605_24498606insT	uc002rfe.2	-	18	2315_2316	c.2057_2058insA	c.(2056-2058)AAGfs	p.K686fs	ITSN2_uc002rff.2_Frame_Shift_Ins_p.K659fs|ITSN2_uc002rfg.2_Frame_Shift_Ins_p.K686fs	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	686	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTCTAGTTTCTTTTTCTGCAT	0.327													---	---	---								T	24498606	T	T	24498605	7	5	209	1	0	1	1	0	0	0	0	0	7966	912	32	0	3178	0	ITSN2	2	24498605	Frame_Shift_Ins	INS	-	TCGA-CV-6954-01A-11D-1912-08		24498605	218700768	23	38067											
XDH	7498	broad.mit.edu	37	chr2	31600014	31600014	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgtacctctgtggttccTggcttgaataaaactctcat	8	15	7	11	0	2	1	1	1	2	0	5	1	4	1	3	2	2	3	3	2	4	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:31600014T>A	uc002rnv.1	-	14	1411	c.1332A>T	c.(1330-1332)CCA>CCT	p.P444P		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	444					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CTGTGGTTCCTGGCTTGAATA	0.502													6	94					0	0	0	0	A	31600014	A	A	31600014	2	1	209	1	0	0	0	0	0	0	0	1	17494	1567	55	5		5	XDH	2	31600014	Silent	SNP	T	TCGA-CV-6954-01A-11D-1912-08	7101409	31600014	211599359	24	38068											
SRD5A2	6716	broad.mit.edu	37	chr2	31805847	31805847	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggcaggcgggtagccgccgGcttcaggctctccgtgtgct	3	9	16	13	4	2	0	1	0	1	0	3	0	2	0	3	5	2	5	3	5	1	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:31805847G>A	uc002rnw.1	-	2	195	c.124C>T	c.(124-126)CCG>TCG	p.P42S		NM_000348	NP_000339	P31213	S5A2_HUMAN	3-oxo-5 alpha-steroid 4-dehydrogenase 2	42					androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity				0	Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	GTAGCCGCCGGCTTCAGGCTC	0.721													8	27					0	0	0	0	A	31805847	A	A	31805847	3	1	209	1	0	0	0	0	1	0	0	0	15205	1194	42	4	660	4	SRD5A2	2	31805847	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	205833	31805847	211393526	25	38069											
C2orf63	130162	broad.mit.edu	37	chr2	55407665	55407666	+	Missense_Mutation	DNP	CT	AA	AA																															ccggtagtaaagtccttcaaCtgctgtatgtactccatgac																										TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:55407665_55407666CT>AA	uc002ryi.2	-	11	1710_1711	c.1364_1365AG>TT	c.(1363-1365)CAG>CTT	p.Q455L	C2orf63_uc002ryh.2_Missense_Mutation_p.Q6L|C2orf63_uc002ryj.2_Missense_Mutation_p.Q333L	NM_152385	NP_689598	Q8NHS4	CB063_HUMAN	hypothetical protein LOC130162 isoform 1	455							binding			ovary(2)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(58;0.179)|Lung(47;0.189)			AGTCCTTCAACTGCTGTATGTA	0.391													4	74					0	0	0	0	AA	55407666	AA	AA	55407665	3	1	209	1	0	0	0	0	1	0	0	0	2192	564	20	4	407	4	C2orf63	2	55407665	Missense_Mutation	DNP	CT	TCGA-CV-6954-01A-11D-1912-08	23601818	55407665	187791708	26	38070											
CCDC88A	55704	broad.mit.edu	37	chr2	55539617	55539617	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatccttgctttccatattCtgctccaaaagtgttctgtt	8	17	6	10	0	2	1	0	0	2	1	5	1	5	1	3	0	2	4	3	0	3	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:55539617C>G	uc002ryv.2	-	23	4871	c.4029G>C	c.(4027-4029)CAG>CAC	p.Q1343H	CCDC88A_uc010yoz.1_Missense_Mutation_p.Q1344H|CCDC88A_uc010ypa.1_Missense_Mutation_p.Q1343H|CCDC88A_uc002ryu.2_Missense_Mutation_p.Q626H|CCDC88A_uc002rys.2_Missense_Mutation_p.Q329H|CCDC88A_uc002ryw.2_Missense_Mutation_p.Q627H|CCDC88A_uc010fby.1_Missense_Mutation_p.Q223H	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1344	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TTTCCATATTCTGCTCCAAAA	0.328													13	54					0	0	0	0	G	55539617	G	G	55539617	3	3	209	1	0	0	0	0	1	0	0	0	2876	912	32	2	1623	2	CCDC88A	2	55539617	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	131952	55539617	187659756	27	38071											
ANKRD36	375248	broad.mit.edu	37	chr2	97845475	97845475	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatcccttttgcttttcagTgtcttctcagaaacaaccag	9	15	6	11	0	3	1	2	0	2	1	5	1	4	1	2	0	3	2	2	0	3	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:97845475T>G	uc010yva.1	+	23	1878	c.1634T>G	c.(1633-1635)GTG>GGG	p.V545G	ANKRD36_uc010fic.2_Missense_Mutation_p.V264G|ANKRD36_uc002sxo.2_Intron|ANKRD36_uc002sxp.3_RNA|ANKRD36_uc002sxq.1_Intron	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	545											0						TGCTTTTCAGTGTCTTCTCAG	0.299													4	36					0	0	0	0	G	97845475	G	G	97845475	3	3	209	1	0	0	0	0	1	0	0	0	665	1710	59	5	1724	5	ANKRD36	2	97845475	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	42305858	97845475	145353898	28	38072											
SLC5A7	60482	broad.mit.edu	37	chr2	108625031	108625031	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtatatttctttctttGgtcttggtgcagtttctgct	3	22	9	7	0	4	0	0	0	4	0	4	0	4	0	0	2	2	4	0	2	2	7			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:108625031G>T	uc002tdv.2	+	8	1282	c.1006G>T	c.(1006-1008)GGT>TGT	p.G336C	SLC5A7_uc010ywm.1_Missense_Mutation_p.G89C|SLC5A7_uc010fjj.2_Missense_Mutation_p.G336C|SLC5A7_uc010ywn.1_Missense_Mutation_p.G223C	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	336	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TTCTTTCTTTGGTCTTGGTGC	0.443													9	39					0.00448238	0.00490326	1	0	T	108625031	T	T	108625031	3	4	209	1	0	0	0	0	1	0	0	0	14734	1348	47	4	1032	4	SLC5A7	2	108625031	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	10779556	108625031	134574342	29	38073											
RANBP2	5903	broad.mit.edu	37	chr2	109383950	109383950	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgttgttcctttacctgatCtagttgaagtatccagtggt	7	17	9	8	0	1	2	0	2	1	0	3	2	3	2	3	1	1	4	3	1	4	7			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:109383950C>G	uc002tem.3	+	20	7081	c.6955C>G	c.(6955-6957)CTA>GTA	p.L2319V		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2319	RanBD1 3.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TTTACCTGATCTAGTTGAAGT	0.393													102	164					0	0	0	0	G	109383950	G	G	109383950	3	3	209	1	0	0	0	0	1	0	0	0	13093	912	32	2	7033	2	RANBP2	2	109383950	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	758919	109383950	133815423	30	38074											
HOXD12	3238	broad.mit.edu	37	chr2	176964535	176964535	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccctttgttggagatgtgTgagcgcagtctctacagagc	8	11	13	9	1	1	3	0	1	1	2	2	4	1	3	1	1	4	2	1	1	1	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:176964535T>C	uc010zev.1	+	1	6	c.6T>C	c.(4-6)TGT>TGC	p.C2C	HOXD12_uc010zew.1_Silent_p.C2C	NM_021193	NP_067016	P35452	HXD12_HUMAN	homeobox D12	2						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		TGGAGATGTGTGAGCGCAGTC	0.542													76	85					0	0	0	0	C	176964535	C	C	176964535	2	2	209	1	0	0	0	0	0	0	0	1	7360	1702	59	5		5	HOXD12	2	176964535	Silent	SNP	T	TCGA-CV-6954-01A-11D-1912-08	67580585	176964535	66234838	31	38075											
TTN	7273	broad.mit.edu	37	chr2	179602873	179602873	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttggaagctttgcatgtataCtcgccgcagtcaaccacctg	9	11	9	12	2	1	0	1	0	0	0	2	1	1	1	3	1	4	4	3	1	4	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:179602873C>G	uc010zfg.1	-	46	10799	c.10575G>C	c.(10573-10575)GAG>GAC	p.E3525D	TTN_uc010zfh.1_Missense_Mutation_p.E4598D|TTN_uc010zfi.1_Missense_Mutation_p.E4531D|TTN_uc010zfj.1_Missense_Mutation_p.E4406D|TTN_uc002umz.1_Missense_Mutation_p.E186D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4452							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCATGTATACTCGCCGCAGT	0.453													11	65					0	0	0	0	G	179602873	G	G	179602873	3	3	209	1	0	0	0	0	1	0	0	0	16803	564	20	4	90478	4	TTN	2	179602873	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	2638338	179602873	63596500	32	38076											
DIS3L2	129563	broad.mit.edu	37	chr2	233128057	233128057	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atttccccagagcatagcagCgaggaggtacaccaggccgt	11	6	12	12	2	0	1	0	0	0	1	1	3	1	2	4	3	4	3	4	3	2	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:233128057C>T	uc010fxz.2	+	13	1842	c.1566C>T	c.(1564-1566)AGC>AGT	p.S522S	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	522							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		AGCATAGCAGCGAGGAGGTAC	0.542													14	59					0	0	0	0	T	233128057	T	T	233128057	2	4	209	1	0	0	0	0	0	0	0	1	4559	767	27	1		1	DIS3L2	2	233128057	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	53525184	233128057	10071316	33	38077											
USP40	55230	broad.mit.edu	37	chr2	234465540	234465540	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacattctttacaaacaatCtggttaacaatggttccatg	13	15	5	8	0	2	0	0	0	2	0	3	0	3	0	1	2	4	2	1	2	6	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:234465540C>G	uc010zmu.1	-	5	625	c.507G>C	c.(505-507)CAG>CAC	p.Q169H	USP40_uc010zmr.1_Missense_Mutation_p.Q181H			Q9NVE5	UBP40_HUMAN	SubName: Full=cDNA FLJ56772, highly similar to Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15);	169					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		TACAAACAATCTGGTTAACAA	0.368													10	39					0	0	0	0	G	234465540	G	G	234465540	3	3	209	1	0	0	0	0	1	0	0	0	17140	912	32	2	3312	2	USP40	2	234465540	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	1337483	234465540	8733833	34	38078											
AGAP1	116987	broad.mit.edu	37	chr2	236877176	236877176	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagccccaagctcgacccGcccccctcccctcacgccaa	8	3	5	25	3	1	0	1	0	0	0	3	1	2	0	10	0	2	1	10	0	2	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr2:236877176G>C	uc002vvs.2	+	13	2149	c.1554G>C	c.(1552-1554)CCG>CCC	p.P518P	AGAP1_uc002vvt.2_Silent_p.P465P	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	518	PH.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						AGCTCGACCCGCCCCCCTCCC	0.577													4	54					0	0	0	0	C	236877176	C	C	236877176	2	2	209	1	0	0	0	0	0	0	0	1	366	1074	38	3		3	AGAP1	2	236877176	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	2411636	236877176	6322197	35	38079											
TGFBR2	7048	broad.mit.edu	37	chr3	30732963	30732963	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgctgggaccacgacccaGaggcccgtctcacagcccag	9	4	12	16	2	1	1	1	0	1	1	2	3	1	2	4	2	2	1	4	2	0	0	rs121918714		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:30732963G>T	uc003ceo.2	+	7	1958	c.1576G>T	c.(1576-1578)GAG>TAG	p.E526*	TGFBR2_uc003cen.2_Nonsense_Mutation_p.E551*	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	526	Protein kinase.|Cytoplasmic (Potential).		E -> Q (in esophageal cancer).		activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CCACGACCCAGAGGCCCGTCT	0.602													32	26					2.08457e-15	2.66871e-15	1	0	T	30732963	T	T	30732963	4	4	209	1	0	0	0	0	0	1	0	0	15888	943	33	2	1681	2	TGFBR2	3	30732963	Nonsense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08		30732963	167289467	36	38080											
SCN11A	11280	broad.mit.edu	37	chr3	38888436	38888436	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attggcttccatgaacttctCttccatcattgctttcatac	8	17	4	12	0	3	1	2	1	1	0	6	1	5	1	2	1	3	2	2	1	2	7			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:38888436C>G	uc011ays.1	-	26	5324	c.5125G>C	c.(5125-5127)GAG>CAG	p.E1709Q		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1709					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ATGAACTTCTCTTCCATCATT	0.458													30	95					0	0	0	0	G	38888436	G	G	38888436	3	3	209	1	0	0	0	0	1	0	0	0	13978	922	32	2	254	2	SCN11A	3	38888436	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	8155473	38888436	159133994	37	38081											
CCR2	729230	broad.mit.edu	37	chr3	46399419	46399419	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcttcttcatcatcctccTgacaatcgatagatacctgg	11	13	5	12	1	4	2	2	1	2	1	7	3	6	2	3	1	1	0	3	1	4	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:46399419T>A	uc003cpn.3	+	2	886	c.401T>A	c.(400-402)CTG>CAG	p.L134Q	CCR2_uc003cpm.3_Missense_Mutation_p.L134Q	NM_001123041	NP_001116513	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2 isoform A	134	Helical; Name=3; (Potential).				astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			lung(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		ATCATCCTCCTGACAATCGAT	0.463													22	419					0	0	0	0	A	46399419	A	A	46399419	3	1	209	1	0	0	0	0	1	0	0	0	2956	1580	55	5	403	5	CCR2	3	46399419	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	7510983	46399419	151623011	38	38082											
ZBTB11	27107	broad.mit.edu	37	chr3	101375081	101375081	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatgcttatagataaaagtCtttccacagacctaagatag	15	11	6	9	0	1	3	0	0	1	3	2	3	2	3	3	0	1	1	3	0	6	6	rs144559723		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:101375081C>G	uc003dve.3	-	7	2288	c.2058G>C	c.(2056-2058)AAG>AAC	p.K686N		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	686	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						AGATAAAAGTCTTTCCACAGA	0.333													7	32					0	0	0	0	G	101375081	G	G	101375081	3	3	209	1	0	0	0	0	1	0	0	0	17591	912	32	2	1123	2	ZBTB11	3	101375081	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	54975662	101375081	96647349	39	38083											
TRH	7200	broad.mit.edu	37	chr3	129695649	129695649	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggaagaggaagaaggggggGctgtgggaccccacaaacgg	13	2	19	7	1	0	2	0	0	0	2	0	5	0	5	2	7	1	1	2	7	4	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:129695649G>T	uc003enc.2	+	3	880	c.319G>T	c.(319-321)GCT>TCT	p.A107S		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	107					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						agaagggggggCTGTGGGACC	0.428													5	80					0.000602214	0.000671368	1	0	T	129695649	T	T	129695649	3	4	209	1	0	0	0	0	1	0	0	0	16545	1203	42	4	325	4	TRH	3	129695649	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	28320568	129695649	68326781	40	38084											
STAG1	10274	broad.mit.edu	37	chr3	136219098	136219098	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaatatacccttaaaaataGagttcatcatattttcgatt	16	15	3	7	1	2	1	2	0	0	1	3	2	2	1	1	0	1	1	1	0	8	9			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:136219098G>C	uc003era.1	-	9	1161	c.869C>G	c.(868-870)TCT>TGT	p.S290C	STAG1_uc003erb.1_Missense_Mutation_p.S290C|STAG1_uc003erc.1_Missense_Mutation_p.S64C|STAG1_uc010hua.1_Missense_Mutation_p.S153C|STAG1_uc003erd.2_Missense_Mutation_p.S193C	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	290					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						CTTAAAAATAGAGTTCATCAT	0.279													4	8					0	0	0	0	C	136219098	C	C	136219098	3	2	209	1	0	0	0	0	1	0	0	0	15308	942	33	2	3011	2	STAG1	3	136219098	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	6523449	136219098	61803332	41	38085											
CLDN18	51208	broad.mit.edu	37	chr3	137749921	137749921	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaaaaacaagaagatatacGatggaggtgcccgcacagag	17	4	11	9	2	0	3	0	0	0	3	0	5	0	4	2	2	3	1	2	2	6	2	rs141484279		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:137749921G>A	uc003ero.1	+	5	777	c.724G>A	c.(724-726)GAT>AAT	p.D242N	CLDN18_uc003erp.1_Missense_Mutation_p.D242N|CLDN18_uc010hue.1_Missense_Mutation_p.D198N	NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	242	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2						GAAGATATACGATGGAGGTGC	0.517													27	149					0	0	0	0	A	137749921	A	A	137749921	3	1	209	1	0	0	0	0	1	0	0	0	3494	1058	37	1	966	1	CLDN18	3	137749921	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	1530823	137749921	60272509	42	38086											
DBR1	51163	broad.mit.edu	37	chr3	137893473	137893474	+	Frame_Shift_Ins	INS	-	GT	GT																															gcatgtgacgatacttgggcINSggcacggccatgcagcgtag																										TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:137893473_137893474insGT	uc003erv.2	-	1	300_301	c.164_165insAC	c.(163-165)CCGfs	p.P55fs	DBR1_uc003eru.2_Frame_Shift_Ins_p.P4fs	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	55						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						GATACTTGGGCGGCACGGCCAT	0.693													---	---	---								GT	137893474	GT	GT	137893473	7	5	209	1	0	1	1	0	0	0	0	0	4274	755	27	0	1501	0	DBR1	3	137893473	Frame_Shift_Ins	INS	-	TCGA-CV-6954-01A-11D-1912-08	143552	137893473	60128957	43	38087											
RASA2	5922	broad.mit.edu	37	chr3	141328366	141328366	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	taagctgcagaagatggaagGtaaatacacaatctattttt	16	12	8	5	0	1	2	0	0	1	2	1	3	1	3	0	2	3	3	0	2	8	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:141328366G>T	uc003etz.1	+	22	2329	c.2329_splice	c.e22+1	p.E777_splice	RASA2_uc010huq.1_Splice_Site_p.E781_splice|RASA2_uc003eua.1_Splice_Site_p.E778_splice	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2						intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						AAGATGGAAGGTAAATACACA	0.303													5	54					3.59834e-05	4.17121e-05	1	0	T	141328366	T	T	141328366	5	4	209	1	0	0	0	0	0	0	1	0	13126	1275	44	4	2416	4	RASA2	3	141328366	Splice_Site	SNP	G	TCGA-CV-6954-01A-11D-1912-08	3434893	141328366	56694064	44	38088											
ATR	545	broad.mit.edu	37	chr3	142215313	142215313	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtgaccagcctttctagctaCcctggcactctgcagccagc	7	9	9	16	0	2	1	0	1	2	0	2	1	2	1	4	1	6	3	4	1	2	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:142215313C>T	uc003eux.3	-	34	5910	c.5788G>A	c.(5788-5790)GTA>ATA	p.V1930I		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1930	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TTTCTAGCTACCCTGGCACTC	0.488								Other_conserved_DNA_damage_response_genes					4	97					0	0	0	0	T	142215313	T	T	142215313	3	4	209	1	0	0	0	0	1	0	0	0	1206	507	18	4	2202	4	ATR	3	142215313	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	886947	142215313	55807117	45	38089											
ATR	545	broad.mit.edu	37	chr3	142281919	142281919	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagggagttgctgcaatccGcagaagtctcgttatgatcc	9	10	13	9	2	1	2	0	1	1	1	4	4	3	4	2	2	2	5	2	2	3	2	rs146405935	by1000genomes	TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr3:142281919G>A	uc003eux.3	-	4	447	c.325C>T	c.(325-327)CGG>TGG	p.R109W		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	109					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						GCTGCAATCCGCAGAAGTCTC	0.313								Other_conserved_DNA_damage_response_genes					5	158					0	0	0	0	A	142281919	A	A	142281919	3	1	209	1	0	0	0	0	1	0	0	0	1206	1086	38	1	7785	1	ATR	3	142281919	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	66606	142281919	55740511	46	38090											
FAM53A	152877	broad.mit.edu	37	chr4	1656773	1656773	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcacgcctccgtttgcGccggctcctcttcccactga	3	11	7	20	4	2	1	1	1	1	0	6	1	6	1	6	1	1	2	6	1	0	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr4:1656773G>A	uc011bve.1	-	4	1012	c.814C>T	c.(814-816)CGC>TGC	p.R272C	FAM53A_uc010ibw.2_Missense_Mutation_p.R272C	NM_001013622	NP_001013644	Q6NSI3	FA53A_HUMAN	dorsal neural-tube nuclear protein	272	Nuclear localization signal (Potential).					nucleus					0		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			CTCCGTTTGCGCCGGCTCCTC	0.667													11	40					0	0	0	0	A	1656773	A	A	1656773	3	1	209	1	0	0	0	0	1	0	0	0	5611	1087	38	1	390	1	FAM53A	4	1656773	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08		1656773	189497503	47	38091											
EVC2	132884	broad.mit.edu	37	chr4	5627547	5627547	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcttttcctgctttaagtCattgtccaacttctgcttga	6	20	5	10	0	3	1	1	1	2	0	5	1	5	1	2	0	3	2	2	0	2	8			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr4:5627547C>T	uc003gij.2	-	13	2029	c.1975G>A	c.(1975-1977)GAC>AAC	p.D659N	EVC2_uc011bwb.1_Missense_Mutation_p.D99N|EVC2_uc003gik.2_Missense_Mutation_p.D579N	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	659	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						TGCTTTAAGTCATTGTCCAAC	0.383													19	124					0	0	0	0	T	5627547	T	T	5627547	3	4	209	1	0	0	0	0	1	0	0	0	5310	826	29	2	1991	2	EVC2	4	5627547	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	3970774	5627547	185526729	48	38092											
TLR1	7096	broad.mit.edu	37	chr4	38800207	38800207	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaacactgatatcaagataCtggattctattatgagaaat	18	12	6	5	0	2	3	1	2	1	2	2	5	2	4	0	1	2	0	0	1	8	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr4:38800207C>T	uc003gtl.2	-	4	520	c.246G>A	c.(244-246)CAG>CAA	p.Q82Q		NM_003263	NP_003254	Q15399	TLR1_HUMAN	toll-like receptor 1 precursor	82	Extracellular (Potential).|LRR 2.				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			lung(2)|skin(2)|prostate(1)	5						TATCAAGATACTGGATTCTAT	0.343													8	192					0	0	0	0	T	38800207	T	T	38800207	2	4	209	1	0	0	0	0	0	0	0	1	16015	564	20	4		4	TLR1	4	38800207	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	33172660	38800207	152354069	49	38093											
SLAIN2	57606	broad.mit.edu	37	chr4	48380075	48380075	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttatacttcctggaaattCaggtaaggagaaaatgatat	15	12	9	5	0	1	2	1	1	0	1	2	4	2	3	1	3	1	2	1	3	7	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr4:48380075C>G	uc003gya.3	+	3	845	c.701C>G	c.(700-702)TCA>TGA	p.S234*		NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	234						centrosome					0						CCTGGAAATTCAGGTAAGGAG	0.398													3	128					0	0	0	0	G	48380075	G	G	48380075	4	3	209	1	0	0	0	0	0	1	0	0	14431	838	29	2	711	2	SLAIN2	4	48380075	Nonsense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	9579868	48380075	142774201	50	38094											
LRRC66	339977	broad.mit.edu	37	chr4	52861436	52861436	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttacagagggaagctgtTatttctccggagagggaagg	11	11	14	5	1	1	2	0	0	1	2	2	5	1	4	1	4	2	2	1	4	4	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr4:52861436T>C	uc003gzi.2	-	4	1765	c.1752A>G	c.(1750-1752)ATA>ATG	p.I584M		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	584						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GGGAAGCTGTTATTTCTCCGG	0.498													7	247					0	0	0	0	C	52861436	C	C	52861436	3	2	209	1	0	0	0	0	1	0	0	0	9068	1744	61	5	894	5	LRRC66	4	52861436	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	4481361	52861436	138292840	51	38095											
EPHA5	2044	broad.mit.edu	37	chr4	66213889	66213889	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcggaaagctattgcttcTggggcagtccatctgattgg	7	14	12	8	1	2	1	0	1	2	0	4	2	3	2	1	4	2	3	1	4	2	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr4:66213889T>A	uc003hcy.2	-	15	2734	c.2541A>T	c.(2539-2541)CCA>CCT	p.P847P	EPHA5_uc003hcx.2_Silent_p.P779P|EPHA5_uc003hcz.2_Silent_p.P825P|EPHA5_uc011cah.1_Silent_p.P848P|EPHA5_uc011cai.1_Silent_p.P826P|EPHA5_uc003hda.2_Silent_p.P848P	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	847	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CTATTGCTTCTGGGGCAGTCC	0.413										TSP Lung(17;0.13)			13	50					0	0	0	0	A	66213889	A	A	66213889	2	1	209	1	0	0	0	0	0	0	0	1	5194	1567	55	5		5	EPHA5	4	66213889	Silent	SNP	T	TCGA-CV-6954-01A-11D-1912-08	13352453	66213889	124940387	52	38096											
EPHA5	2044	broad.mit.edu	37	chr4	66217243	66217243	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcacatagcccatgtcagaaAggtacttcattcctgcagag	12	9	9	11	0	2	2	2	0	0	2	3	2	3	2	2	1	3	3	2	1	3	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr4:66217243A>G	uc003hcy.2	-	14	2565	c.2372T>C	c.(2371-2373)CTT>CCT	p.L791P	EPHA5_uc003hcx.2_Missense_Mutation_p.L723P|EPHA5_uc003hcz.2_Missense_Mutation_p.L769P|EPHA5_uc011cah.1_Missense_Mutation_p.L792P|EPHA5_uc011cai.1_Missense_Mutation_p.L770P|EPHA5_uc003hda.2_Missense_Mutation_p.L792P	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	791	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CATGTCAGAAAGGTACTTCAT	0.423										TSP Lung(17;0.13)			8	29					0	0	0	0	G	66217243	G	G	66217243	3	3	209	1	0	0	0	0	1	0	0	0	5194	72	3	5	761	5	EPHA5	4	66217243	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	3354	66217243	124937033	53	38097											
ARHGAP10	79658	broad.mit.edu	37	chr4	148944475	148944475	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctgtcagcatcaccccCaaatgcgccaccaaggcagt	10	6	8	17	1	2	0	2	0	0	0	2	0	2	0	5	1	3	2	5	1	2	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr4:148944475C>G	uc003ilf.2	+	19	1778	c.1778C>G	c.(1777-1779)CCA>CGA	p.P593R	ARHGAP10_uc003ilg.2_Missense_Mutation_p.P242R|ARHGAP10_uc003ilh.2_Missense_Mutation_p.P174R|ARHGAP10_uc003ili.2_Missense_Mutation_p.P26R	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	593					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		GCATCACCCCCAAATGCGCCA	0.512													9	57					0	0	0	0	G	148944475	G	G	148944475	3	3	209	1	0	0	0	0	1	0	0	0	862	594	21	4	1852	4	ARHGAP10	4	148944475	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	82727232	148944475	42209801	54	38098											
DNAH5	1767	broad.mit.edu	37	chr5	13762885	13762885	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggaagccatagctttcgtCcaggaacaaagaccagctac	15	6	9	11	1	0	1	0	0	0	1	2	3	1	3	3	2	5	2	3	2	6	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:13762885C>T	uc003jfd.2	-	60	10269	c.10227G>A	c.(10225-10227)TGG>TGA	p.W3409*	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3409	Stalk (By similarity).		W -> S (in CILD3).		microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TAGCTTTCGTCCAGGAACAAA	0.448									Kartagener_syndrome				29	106					0	0	0	0	T	13762885	T	T	13762885	4	4	209	1	0	0	0	0	0	1	0	0	4626	856	30	2	3727	2	DNAH5	5	13762885	Nonsense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08		13762885	167152375	55	38099											
CARD6	84674	broad.mit.edu	37	chr5	40852441	40852441	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgatgaaagttcaagcacGagatgtgaccgctagggatt	12	9	12	8	2	1	4	1	3	0	1	1	6	1	5	2	1	1	3	2	1	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:40852441G>A	uc003jmg.2	+	3	1082	c.1007G>A	c.(1006-1008)CGA>CAA	p.R336Q		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	336					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						GTTCAAGCACGAGATGTGACC	0.458													12	83					0	0	0	0	A	40852441	A	A	40852441	3	1	209	1	0	0	0	0	1	0	0	0	2662	1058	37	1	1017	1	CARD6	5	40852441	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	27089556	40852441	140062819	56	38100											
HCN1	348980	broad.mit.edu	37	chr5	45262321	45262321	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggacacctcatggggcagcGagggctgcgaggcggagagt	8	5	19	9	3	1	1	1	0	0	1	1	5	1	2	1	6	2	2	1	6	0	0	rs140758934		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:45262321G>A	uc003jok.2	-	8	2400	c.2375C>T	c.(2374-2376)TCG>TTG	p.S792L		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	792	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ATGGGGCAGCGAGGGCTGCGA	0.637													13	151					0	0	0	0	A	45262321	A	A	45262321	3	1	209	1	0	0	0	0	1	0	0	0	7035	1059	37	1	301	1	HCN1	5	45262321	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	4409880	45262321	135652939	57	38101											
ITGA1	3672	broad.mit.edu	37	chr5	52211331	52211331	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggatggtaagacactgaaatTttttggccagtctatccacg	11	12	10	8	1	1	2	0	1	1	1	2	3	2	3	2	3	0	1	2	3	3	5	rs138709169		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:52211331T>G	uc003jou.2	+	15	1947	c.1895T>G	c.(1894-1896)TTT>TGT	p.F632C	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Missense_Mutation_p.F163C	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	632	Extracellular (Potential).|FG-GAP 7.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				ACACTGAAATTTTTTGGCCAG	0.423													3	143					0	0	0	0	G	52211331	G	G	52211331	3	3	209	1	0	0	0	0	1	0	0	0	7911	1841	64	5	1953	5	ITGA1	5	52211331	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	6949010	52211331	128703929	58	38102											
ISCA1P1	389293	broad.mit.edu	37	chr5	62073029	62073029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcagggtgagggctgcccggGtgggctgcagcttcctcttg	3	10	17	11	1	2	1	1	1	1	0	3	1	3	1	2	4	3	4	2	4	0	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:62073029G>C	uc003jtf.2	-	1	142	c.62C>G	c.(61-63)ACC>AGC	p.T21S		NM_001080540	NP_001074009			iron-sulfur cluster assembly 1 homolog (S.												0						GGCTGCCCGGGTGGGCTGCAG	0.582													20	12					0	0	0	0	C	62073029	C	C	62073029	3	2	209	1	0	0	0	0	1	0	0	0	7889	1261	44	4	344	4	ISCA1P1	5	62073029	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	9861698	62073029	118842231	59	38103											
GPR98	84059	broad.mit.edu	37	chr5	90040951	90040951	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttttgttctggaagtaccTtctgcttatgatgtggcttc	5	19	9	8	0	3	1	0	1	3	0	4	2	3	2	1	2	2	4	1	2	3	7			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:90040951T>A	uc003kju.2	+	51	10734	c.10638T>A	c.(10636-10638)CCT>CCA	p.P3546P	GPR98_uc003kjt.2_Silent_p.P1252P|GPR98_uc003kjv.2_Silent_p.P1146P	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3546	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGGAAGTACCTTCTGCTTATG	0.408													9	287					0	0	0	0	A	90040951	A	A	90040951	2	1	209	1	0	0	0	0	0	0	0	1	6760	1596	56	5		5	GPR98	5	90040951	Silent	SNP	T	TCGA-CV-6954-01A-11D-1912-08	27967922	90040951	90874309	60	38104											
PSD2	84249	broad.mit.edu	37	chr5	139193154	139193154	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttgagggggacatgggggCagctggtggtgatggggagc	6	8	23	4	0	0	2	0	2	0	0	0	4	0	4	0	8	2	3	0	8	0	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:139193154C>A	uc003leu.1	+	3	837	c.632C>A	c.(631-633)GCA>GAA	p.A211E		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	211					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACATGGGGGCAGCTGGTGGT	0.687													4	52					0.000602214	0.000671368	1	0	A	139193154	A	A	139193154	3	1	209	1	0	0	0	0	1	0	0	0	12709	710	25	4	638	4	PSD2	5	139193154	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	49152203	139193154	41722106	61	38105											
PCDHB7	56129	broad.mit.edu	37	chr5	140553868	140553868	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agagactcgggcaccaacgcCcaggtcatctactccctgct	9	7	9	16	2	2	1	1	0	1	1	4	2	3	1	3	2	3	2	3	2	2	1	rs149570059		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:140553868C>T	uc003lit.2	+	1	1626	c.1452C>T	c.(1450-1452)GCC>GCT	p.A484A		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	484	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACCAACGCCCAGGTCATCT	0.642													28	112					0	0	0	0	T	140553868	T	T	140553868	2	4	209	1	0	0	0	0	0	0	0	1	11601	610	22	4		4	PCDHB7	5	140553868	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	1360714	140553868	40361392	62	38106											
SPINK5	11005	broad.mit.edu	37	chr5	147513386	147513386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaaacaaatacacacatccGcagtacagggaagtgtgagg	16	5	10	10	1	0	1	0	1	0	0	1	2	1	2	2	2	3	2	2	2	5	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:147513386G>A	uc003lox.2	+	32	3195	c.3122G>A	c.(3121-3123)CGC>CAC	p.R1041H	SPINK5_uc003loy.2_Missense_Mutation_p.R1071H	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	1041	Kazal-like 15.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACACATCCGCAGTACAGGG	0.468													14	44					0	0	0	0	A	147513386	A	A	147513386	3	1	209	1	0	0	0	0	1	0	0	0	15128	1087	38	1	3354	1	SPINK5	5	147513386	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	6959518	147513386	33401874	63	38107											
FAT2	2196	broad.mit.edu	37	chr5	150885203	150885203	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atagttggggggcacccgggGctggccctggcctgcaagag	6	6	18	11	1	0	1	0	0	0	1	0	1	0	1	3	7	1	4	3	7	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:150885203G>A	uc003lue.3	-	23	12986	c.12973C>T	c.(12973-12975)CCC>TCC	p.P4325S	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.P932S	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	4325	Cytoplasmic (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCACCCGGGGCTGGCCCTGG	0.622													16	18					0	0	0	0	A	150885203	A	A	150885203	3	1	209	1	0	0	0	0	1	0	0	0	5722	1203	42	4	80	4	FAT2	5	150885203	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	3371817	150885203	30030057	64	38108											
HRH2	3274	broad.mit.edu	37	chr5	175110708	175110708	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtctatccacctggggTggaacagcaggaacgagacc	10	8	12	11	1	2	1	0	0	2	1	3	4	3	3	3	4	3	1	3	4	3	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:175110708T>A	uc003mdd.2	+	1	2245	c.472T>A	c.(472-474)TGG>AGG	p.W158R	HRH2_uc003mdc.3_Missense_Mutation_p.W158R	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	158	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CCACCTGGGGTGGAACAGCAG	0.547													15	43					0	0	0	0	A	175110708	A	A	175110708	3	1	209	1	0	0	0	0	1	0	0	0	7395	1696	59	5	474	5	HRH2	5	175110708	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	24225505	175110708	5804552	65	38109											
BTNL9	153579	broad.mit.edu	37	chr5	180483002	180483002	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcagactggagacgggcTgaaggccaggctggtgagtg	8	7	18	8	1	1	4	1	2	0	2	1	5	1	4	1	5	0	3	1	5	1	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr5:180483002T>G	uc003mmt.2	+	9	1173	c.942T>G	c.(940-942)GCT>GCG	p.A314A		NM_152547	NP_689760	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9 precursor	314	Cytoplasmic (Potential).|B30.2/SPRY.|Potential.					integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGAGACGGGCTGAAGGCCAGG	0.522													4	172					0	0	0	0	G	180483002	G	G	180483002	2	3	209	1	0	0	0	0	0	0	0	1	1573	1567	55	5		5	BTNL9	5	180483002	Silent	SNP	T	TCGA-CV-6954-01A-11D-1912-08	5372294	180483002	432258	66	38110											
SLC17A1	6568	broad.mit.edu	37	chr6	25826725	25826725	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcttctttgtggaggtgttGggcaaaccatgtggatctgt	7	14	14	6	0	2	0	0	0	2	0	2	2	2	2	1	4	2	3	1	4	1	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr6:25826725G>A	uc003nfh.3	-	3	287	c.171C>T	c.(169-171)CCC>CCT	p.P57P	SLC17A1_uc011djy.1_RNA|SLC17A1_uc010jqb.1_Silent_p.P55P|SLC17A1_uc010jqc.1_Silent_p.P55P	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	57					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						TGGAGGTGTTGGGCAAACCAT	0.408													56	176					0	0	0	0	A	25826725	A	A	25826725	2	1	209	1	0	0	0	0	0	0	0	1	14481	1335	47	4		4	SLC17A1	6	25826725	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08		25826725	145288342	67	38111											
HIST1H3E	8353	broad.mit.edu	37	chr6	26225492	26225492	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccggccacgggcggcgtgaAgaagccccatcgctaccgcc	7	4	13	17	6	0	2	0	1	0	1	2	2	1	2	6	3	2	1	6	3	3	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr6:26225492A>T	uc003nhb.2	+	2	470	c.110A>T	c.(109-111)AAG>ATG	p.K37M	HIST1H3E_uc003nhc.3_Missense_Mutation_p.K37M	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	37					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				GGCGGCGTGAAGAAGCCCCAT	0.627													87	56					0	0	0	0	T	26225492	T	T	26225492	3	4	209	1	0	0	0	0	1	0	0	0	7198	72	3	5	112	5	HIST1H3E	6	26225492	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	398767	26225492	144889575	68	38112											
OR5V1	81696	broad.mit.edu	37	chr6	29323045	29323045	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atccaaagaggaaattggtgGctgccacttgctccctatag	11	10	10	10	0	0	1	0	0	0	1	2	2	2	2	3	3	2	2	3	3	4	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr6:29323045G>C	uc011dlo.1	-	1	1010	c.928C>G	c.(928-930)CCA>GCA	p.P310A		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						GAAATTGGTGGCTGCCACTTG	0.368													4	113					0	0	0	0	C	29323045	C	C	29323045	3	2	209	1	0	0	0	0	1	0	0	0	11238	1203	42	4	40	4	OR5V1	6	29323045	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	3097553	29323045	141792022	69	38113											
HSPA1L	3305	broad.mit.edu	37	chr6	31778509	31778509	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggagttgcgctttatcaggGcagtcatcacgcccccagcc	7	9	11	14	2	3	0	3	0	0	0	3	1	3	1	3	2	2	3	3	2	1	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr6:31778509G>T	uc003nxh.2	-	2	1424	c.1241C>A	c.(1240-1242)GCC>GAC	p.A414D	HSPA1L_uc010jte.2_Missense_Mutation_p.A414D	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	414					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						CTTTATCAGGGCAGTCATCAC	0.597													21	226					2.37509e-13	3.00759e-13	1	0	T	31778509	T	T	31778509	3	4	209	1	0	0	0	0	1	0	0	0	7449	1203	42	4	688	4	HSPA1L	6	31778509	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	2455464	31778509	139336558	70	38114											
TAP1	6890	broad.mit.edu	37	chr6	32819997	32819997	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gttgttatagatcccgtcacCcacgaactccagcactgcac	10	9	7	15	2	1	1	1	0	0	1	3	2	3	1	3	0	3	4	3	0	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr6:32819997C>T	uc003ocg.2	-	3	1068	c.913G>A	c.(913-915)GGT>AGT	p.G305S	TAP1_uc011dqi.1_Missense_Mutation_p.G44S|PSMB9_uc011dqj.1_5'Flank|PSMB9_uc003sga.2_5'Flank	NM_000593	NP_000584	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family	305	Helical; Name=6; (Potential).|ABC transmembrane type-1.				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1						ATCCCGTCACCCACGAACTCC	0.537													9	123					0	0	0	0	T	32819997	T	T	32819997	3	4	209	1	0	0	0	0	1	0	0	0	15616	623	22	4	1549	4	TAP1	6	32819997	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	1041488	32819997	138295070	71	38115											
ZNF318	24149	broad.mit.edu	37	chr6	43305026	43305026	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggaccttgacactggagctTtaaccaaattcagagggtcg	11	9	12	9	1	1	2	1	1	0	1	2	4	1	4	2	3	2	1	2	3	2	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr6:43305026T>G	uc003oux.2	-	10	6788	c.6710A>C	c.(6709-6711)AAA>ACA	p.K2237T	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2237					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CACTGGAGCTTTAACCAAATT	0.493													5	119					0	0	0	0	G	43305026	G	G	43305026	3	3	209	1	0	0	0	0	1	0	0	0	17903	1841	64	5	133	5	ZNF318	6	43305026	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	10485029	43305026	127810041	72	38116											
AARS2	57505	broad.mit.edu	37	chr6	44272035	44272035	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtgggtggccgtatgcttCgccatgcagcctagacgcca	7	8	14	12	3	0	1	0	0	0	1	1	1	0	1	4	3	3	3	4	3	2	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr6:44272035C>T	uc010jza.1	-	14	1893	c.1890G>A	c.(1888-1890)GCG>GCA	p.A630A	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_020745	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	630					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			ovary(1)	1	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CCGTATGCTTCGCCATGCAGC	0.627											OREG0017473	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	78					0	0	0	0	T	44272035	T	T	44272035	2	4	209	1	0	0	0	0	0	0	0	1	20	871	31	1		1	AARS2	6	44272035	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	967009	44272035	126843032	73	38117											
FAM162B	221303	broad.mit.edu	37	chr6	117086362	117086362	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaacgccctgtccacagcaGgattttcttgtcgaactgcg	9	10	10	12	3	1	0	0	0	1	0	3	3	2	1	2	1	4	1	2	1	2	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr6:117086362G>A	uc003pxi.2	-	2	376	c.229C>T	c.(229-231)CTG>TTG	p.L77L		NM_001085480	NP_001078949	Q5T6X4	F162B_HUMAN	hypothetical protein LOC221303	77						integral to membrane					0						GTCCACAGCAGGATTTTCTTG	0.632													14	48					0	0	0	0	A	117086362	A	A	117086362	2	1	209	1	0	0	0	0	0	0	0	1	5503	991	35	4		4	FAM162B	6	117086362	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	72814327	117086362	54028705	74	38118											
FNDC1	84624	broad.mit.edu	37	chr6	159687230	159687230	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagttcgtgggagttgttcTttgtaattcactgaggtata	10	16	11	4	1	2	1	1	1	1	0	3	2	2	2	0	2	0	5	0	2	4	8			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr6:159687230T>C	uc010kjv.2	+	21	5599	c.5399T>C	c.(5398-5400)CTT>CCT	p.L1800P		NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1800						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GGAGTTGTTCTTTGTAATTCA	0.443													26	72					0	0	0	0	C	159687230	C	C	159687230	3	2	209	1	0	0	0	0	1	0	0	0	6000	1609	56	5	5481	5	FNDC1	6	159687230	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	42600868	159687230	11427837	75	38119											
PLG	5340	broad.mit.edu	37	chr6	161143527	161143527	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcctccaccaccaccacagGaaagaagtgtcagtcttggt	12	8	8	13	0	2	1	1	0	1	1	4	2	4	2	5	2	0	0	5	2	2	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr6:161143527G>T	uc003qtm.3	+	10	1247	c.1184G>T	c.(1183-1185)GGA>GTA	p.G395V		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	395	Kringle 4.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ACCACCACAGGAAAGAAGTGT	0.493													11	112					3.86212e-05	4.45482e-05	1	0	T	161143527	T	T	161143527	3	4	209	1	0	0	0	0	1	0	0	0	12141	1174	41	2	1226	2	PLG	6	161143527	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	1456297	161143527	9971540	76	38120											
C7orf50	84310	broad.mit.edu	37	chr7	1037377	1037377	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccttctgcaccgtcagctCtcgggcccggccctgcagcc	3	7	11	20	4	3	0	1	0	2	0	4	0	3	0	5	2	4	3	5	2	0	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr7:1037377C>A	uc003sju.2	-	5	539	c.469G>T	c.(469-471)GAG>TAG	p.E157*	C7orf50_uc003sjs.2_RNA|C7orf50_uc011jvt.1_Nonsense_Mutation_p.E157*|C7orf50_uc011jvu.1_Nonsense_Mutation_p.E157*	NM_032350	NP_115726	Q9BRJ6	CG050_HUMAN	hypothetical protein LOC84310	157							protein binding				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		ACCGTCAGCTCTCGGGCCCGG	0.687													5	100					0.00116845	0.00129027	1	0	A	1037377	A	A	1037377	4	1	209	1	0	0	0	0	0	1	0	0	2410	922	32	2	119	2	C7orf50	7	1037377	Nonsense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08		1037377	158101286	77	38121											
CHST12	55501	broad.mit.edu	37	chr7	2472365	2472365	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtactgggacagcgcaggcGccgcgcacttctacttgcac	7	8	12	14	4	1	0	0	0	1	0	1	1	1	1	1	2	4	4	1	2	2	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr7:2472365G>A	uc003smc.2	+	2	226	c.91G>A	c.(91-93)GCC>ACC	p.A31T	CHST12_uc003smd.2_Missense_Mutation_p.A31T	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	31	Lumenal (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CAGCGCAGGCGCCGCGCACTT	0.687													68	63					0	0	0	0	A	2472365	A	A	2472365	3	1	209	1	0	0	0	0	1	0	0	0	3415	1087	38	1	93	1	CHST12	7	2472365	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	1434988	2472365	156666298	78	38122											
OCM	654231	broad.mit.edu	37	chr7	5920406	5920406	+	5'Flank	DEL	T	-	-																															tcttaatttaaaaaaaaaaaTaatctagacacacatacagt																								rs10235465		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr7:5920406delT	uc003spe.3	+							NM_001097622	NP_001091091	P0CE72	ONCO_HUMAN	oncomodulin								calcium ion binding				0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		aaaaaaaaaaTAATCTAGACA	0.229													---	---	---								-	5920406	-	-	5920406	6	5	209	0	1	1	0	1	0	0	0	0	10875	1421	49	0		0	OCM	7	5920406	5'Flank	DEL	T	TCGA-CV-6954-01A-11D-1912-08	3448041	5920406	153218257	79	38123											
THSD7A	221981	broad.mit.edu	37	chr7	11630196	11630196	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagggccgtctggttgccGcgcctcttgtcctgctgact	3	11	13	14	3	2	2	0	1	2	1	3	2	3	2	4	2	2	2	4	2	0	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr7:11630196G>A	uc003ssf.3	-	4	1596	c.1344C>T	c.(1342-1344)CGC>CGT	p.R448R		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	448	Extracellular (Potential).|TSP type-1 4.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TCTGGTTGCCGCGCCTCTTGT	0.557										HNSCC(18;0.044)			10	48					0	0	0	0	A	11630196	A	A	11630196	2	1	209	1	0	0	0	0	0	0	0	1	15945	1074	38	1		1	THSD7A	7	11630196	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	5709790	11630196	147508467	80	38124											
DFNA5	1687	broad.mit.edu	37	chr7	24758712	24758712	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgccaccacacttctccTcgacctgcatgtgctcagag	8	9	8	16	2	2	1	1	0	1	1	4	3	2	1	4	0	3	2	4	0	0	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr7:24758712T>A	uc010kus.1	-	4	618	c.530A>T	c.(529-531)GAG>GTG	p.E177V	DFNA5_uc003swz.2_Missense_Mutation_p.E13V|DFNA5_uc003sxa.1_Missense_Mutation_p.E177V|DFNA5_uc010kut.1_Missense_Mutation_p.E13V|DFNA5_uc003sxb.2_Missense_Mutation_p.E177V	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	177					sensory perception of sound					ovary(1)	1						ACACTTCTCCTCGACCTGCAT	0.577													29	135					0	0	0	0	A	24758712	A	A	24758712	3	1	209	1	0	0	0	0	1	0	0	0	4476	1551	54	5	988	5	DFNA5	7	24758712	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	13128516	24758712	134379951	81	38125											
ELMO1	9844	broad.mit.edu	37	chr7	37250998	37250998	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atagcttacttacaatgaacCcaagcttcttataatctcgc	13	13	4	11	1	2	1	0	1	2	0	3	1	2	1	1	0	5	2	1	0	8	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr7:37250998C>T	uc003tfk.1	-	13	1386	c.1079G>A	c.(1078-1080)GGG>GAG	p.G360E	ELMO1_uc011kbc.1_Missense_Mutation_p.G264E|ELMO1_uc010kxg.1_Missense_Mutation_p.G360E	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	360	ELMO.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						TACAATGAACCCAAGCTTCTT	0.507													4	52					0	0	0	0	T	37250998	T	T	37250998	3	4	209	1	0	0	0	0	1	0	0	0	5089	623	22	4	1144	4	ELMO1	7	37250998	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	12492286	37250998	121887665	82	38126											
SEMA3A	10371	broad.mit.edu	37	chr7	83592582	83592582	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaccagcgctctctgcgacTtcggactgcattccaaaaat	11	9	8	13	3	1	1	0	0	1	1	4	3	2	2	2	1	3	2	2	1	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr7:83592582T>A	uc003uhz.2	-	16	2114	c.1799A>T	c.(1798-1800)AAG>ATG	p.K600M		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	600	Ig-like C2-type.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TCTCTGCGACTTCGGACTGCA	0.438													34	85					0	0	0	0	A	83592582	A	A	83592582	3	1	209	1	0	0	0	0	1	0	0	0	14089	1609	56	5	524	5	SEMA3A	7	83592582	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	46341584	83592582	75546081	83	38127											
TRRAP	8295	broad.mit.edu	37	chr7	98548528	98548528	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catatcttgaatcctgctttCttgtacagctttgagaaggg	9	15	9	8	0	2	2	0	2	2	1	3	3	3	2	1	1	3	3	1	1	4	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr7:98548528C>G	uc003upp.2	+	38	5552	c.5343C>G	c.(5341-5343)TTC>TTG	p.F1781L	TRRAP_uc011kis.1_Missense_Mutation_p.F1763L|TRRAP_uc003upr.2_Missense_Mutation_p.F1480L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1781					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ATCCTGCTTTCTTGTACAGCT	0.418													7	207					0	0	0	0	G	98548528	G	G	98548528	3	3	209	1	0	0	0	0	1	0	0	0	16668	912	32	2	5431	2	TRRAP	7	98548528	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	14955946	98548528	60590135	84	38128											
EFHA2	286097	broad.mit.edu	37	chr8	16948072	16948072	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgtcttcaactttatggAtaccattctcctactaatag	11	14	5	11	1	3	0	1	0	2	0	4	1	3	1	2	1	4	0	2	1	6	8			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr8:16948072A>T	uc003wxd.2	+	8	909	c.867A>T	c.(865-867)GGA>GGT	p.G289G		NM_181723	NP_859074	Q86XE3	EFHA2_HUMAN	EF-hand domain family, member A2	289						integral to membrane	calcium ion binding			skin(1)	1				Colorectal(111;0.0686)|COAD - Colon adenocarcinoma(73;0.239)		AACTTTATGGATACCATTCTC	0.323													6	241					0	0	0	0	T	16948072	T	T	16948072	2	4	209	1	0	0	0	0	0	0	0	1	4966	320	12	5		5	EFHA2	8	16948072	Silent	SNP	A	TCGA-CV-6954-01A-11D-1912-08		16948072	129415950	85	38129											
CHD7	55636	broad.mit.edu	37	chr8	61777711	61777711	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccgctgctgtggcctccaCgtcagggatcaaccctttgc	5	9	11	16	3	2	0	2	0	0	0	3	1	3	1	4	2	3	2	4	2	1	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr8:61777711C>T	uc003xue.2	+	38	8690	c.8213C>T	c.(8212-8214)ACG>ATG	p.T2738M		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2738					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GTGGCCTCCACGTCAGGGATC	0.612													9	17					0	0	0	0	T	61777711	T	T	61777711	3	4	209	1	0	0	0	0	1	0	0	0	3345	536	19	1	8359	1	CHD7	8	61777711	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	44829639	61777711	84586311	86	38130											
ASPH	444	broad.mit.edu	37	chr8	62556539	62556539	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacatcatctcttccataTcctgattacagtcttgtgaa	11	14	5	11	0	3	3	1	2	2	1	6	3	5	3	2	0	1	0	2	0	3	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr8:62556539T>G	uc003xuj.2	-	8	943	c.674A>C	c.(673-675)GAT>GCT	p.D225A	ASPH_uc011leg.1_Missense_Mutation_p.D196A|ASPH_uc003xuo.2_Intron|ASPH_uc011leh.1_Intron|ASPH_uc003xul.2_Missense_Mutation_p.D211A|ASPH_uc011lei.1_Missense_Mutation_p.D211A|ASPH_uc011lej.1_Missense_Mutation_p.D168A|ASPH_uc003xun.2_Missense_Mutation_p.D182A|ASPH_uc011lek.1_Intron|ASPH_uc003xum.2_Missense_Mutation_p.D225A	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	225	Glu-rich.|Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	CTCTTCCATATCCTGATTACA	0.328													7	19					0	0	0	0	G	62556539	G	G	62556539	3	3	209	1	0	0	0	0	1	0	0	0	1055	1435	50	5	1686	5	ASPH	8	62556539	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	778828	62556539	83807483	87	38131											
VPS13B	157680	broad.mit.edu	37	chr8	100513997	100513997	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tacaagtaatattggaggaaCcagtggacgtgttagtttat	13	13	11	4	1	0	0	0	0	0	0	0	3	0	3	1	3	2	3	1	3	7	7			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr8:100513997C>G	uc003yiv.2	+	26	4064	c.3953C>G	c.(3952-3954)ACC>AGC	p.T1318S	VPS13B_uc003yiw.2_Missense_Mutation_p.T1318S|VPS13B_uc003yiu.1_Missense_Mutation_p.T1318S|VPS13B_uc003yix.1_Missense_Mutation_p.T788S	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1318					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATTGGAGGAACCAGTGGACGT	0.423													10	125					0	0	0	0	G	100513997	G	G	100513997	3	3	209	1	0	0	0	0	1	0	0	0	17258	507	18	4	4174	4	VPS13B	8	100513997	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	37957458	100513997	45850025	88	38132											
PKHD1L1	93035	broad.mit.edu	37	chr8	110509169	110509169	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccagtttaatcctgtggaaaAgtggtttgacaatgaagccc	12	11	10	8	0	0	2	0	2	0	0	1	3	1	3	3	2	1	2	3	2	5	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr8:110509169A>T	uc003yne.2	+	64	10453	c.10349A>T	c.(10348-10350)AAG>ATG	p.K3450M		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3450	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCTGTGGAAAAGTGGTTTGAC	0.373										HNSCC(38;0.096)			22	106					0	0	0	0	T	110509169	T	T	110509169	3	4	209	1	0	0	0	0	1	0	0	0	12027	72	3	5	10603	5	PKHD1L1	8	110509169	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	9995172	110509169	35854853	89	38133											
FAM83A	84985	broad.mit.edu	37	chr8	124219421	124219421	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acctggctctgcggacacgtGcaccggaacatcctctccaa	9	7	9	16	3	2	0	0	0	2	0	4	2	3	2	4	3	3	2	4	3	2	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr8:124219421G>C	uc003ypv.2	+	5	2812	c.798G>C	c.(796-798)GTG>GTC	p.V266V	FAM83A_uc003ypw.2_Silent_p.V266V|FAM83A_uc003ypy.2_Silent_p.V210V|FAM83A_uc003ypx.2_Silent_p.V266V|FAM83A_uc003ypz.2_Silent_p.V266V	NM_032899	NP_116288	Q86UY5	FA83A_HUMAN	hypothetical protein LOC84985 isoform a	266										ovary(3)|skin(1)	4	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GCGGACACGTGCACCGGAACA	0.363													7	9					0	0	0	0	C	124219421	C	C	124219421	2	2	209	1	0	0	0	0	0	0	0	1	5665	1306	46	4		4	FAM83A	8	124219421	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	13710252	124219421	22144601	90	38134											
KIAA0196	9897	broad.mit.edu	37	chr8	126091066	126091066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactctctggaaatagctctCgggatagttggatggtcttt	8	14	11	8	1	3	0	0	0	3	0	5	3	3	3	0	4	1	2	0	4	3	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr8:126091066C>T	uc003yrt.2	-	6	954	c.625G>A	c.(625-627)GAG>AAG	p.E209K	KIAA0196_uc011lir.1_Missense_Mutation_p.E61K	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	209					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AAATAGCTCTCGGGATAGTTG	0.423													17	53					0	0	0	0	T	126091066	T	T	126091066	3	4	209	1	0	0	0	0	1	0	0	0	8200	893	31	1	2950	1	KIAA0196	8	126091066	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	1871645	126091066	20272956	91	38135											
SPATC1	375686	broad.mit.edu	37	chr8	145101649	145101649	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caacgggcgggtgcaccctgCgctgaccgagcagctggtga	7	5	16	13	4	0	2	0	2	0	0	0	3	0	2	2	3	5	4	2	3	1	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr8:145101649C>A	uc011lkw.1	+	5	1670	c.1568C>A	c.(1567-1569)GCG>GAG	p.A523E	SPATC1_uc011lkx.1_3'UTR	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	523										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GTGCACCCTGCGCTGACCGAG	0.642													18	49					3.52763e-06	4.17228e-06	1	0	A	145101649	A	A	145101649	3	1	209	1	0	0	0	0	1	0	0	0	15083	768	27	3	1586	3	SPATC1	8	145101649	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	19010583	145101649	1262373	92	38136											
FAM75A6	389730	broad.mit.edu	37	chr9	43627258	43627258	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gggtgtggatgaaataaaggGttggcggtgggacaggggct	9	8	21	3	1	0	1	0	1	0	0	0	3	0	3	0	8	0	2	0	8	3	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr9:43627258G>T	uc011lrb.1	-	4	1458	c.1429C>A	c.(1429-1431)CCC>ACC	p.P477T		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	477						integral to membrane					0						GAAATAAAGGGTTGGCGGTGG	0.522													9	534					0.00448238	0.00490326	1	0	T	43627258	T	T	43627258	3	4	209	1	0	0	0	0	1	0	0	0	5654	1261	44	4	2606	4	FAM75A6	9	43627258	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08		43627258	97586173	93	38137											
ZNF782	158431	broad.mit.edu	37	chr9	99581247	99581247	+	Frame_Shift_Del	DEL	A	-	-																															gaaccttctgatgtacactgAaagttgactggtagctgaat																										TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr9:99581247delA	uc004awp.1	-	6	1339	c.1058delT	c.(1057-1059)TTCfs	p.F353fs	ZNF782_uc011lup.1_Frame_Shift_Del_p.F221fs	NM_001001662	NP_001001662	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	353	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				ATGTACACTGAAAGTTGACTG	0.408													---	---	---								-	99581247	-	-	99581247	7	5	209	1	0	1	0	1	0	0	0	0	18222	246	9	0	1045	0	ZNF782	9	99581247	Frame_Shift_Del	DEL	A	TCGA-CV-6954-01A-11D-1912-08	55953989	99581247	41632184	94	38138											
CORO2A	7464	broad.mit.edu	37	chr9	100895440	100895440	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcacatcttggtgacagctAatcgtactcatggggcttgt	9	13	10	9	1	3	1	2	1	1	0	4	1	3	1	0	3	2	3	0	3	2	4	rs143485689		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr9:100895440A>G	uc004ayl.2	-	5	794	c.528T>C	c.(526-528)ATT>ATC	p.I176I	CORO2A_uc004aym.2_Silent_p.I176I	NM_003389	NP_003380	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	176					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			skin(2)|ovary(1)|pancreas(1)	4		Acute lymphoblastic leukemia(62;0.0559)				GGTGACAGCTAATCGTACTCA	0.542													5	102					0	0	0	0	G	100895440	G	G	100895440	2	3	209	1	0	0	0	0	0	0	0	1	3771	358	13	5		5	CORO2A	9	100895440	Silent	SNP	A	TCGA-CV-6954-01A-11D-1912-08	1314193	100895440	40317991	95	38139											
OR13D1	286365	broad.mit.edu	37	chr9	107457531	107457531	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctacctgttcagcgcacTcgattgtggtcatcttattc	6	16	7	12	2	4	0	2	0	2	0	7	1	4	0	1	1	2	2	1	1	2	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr9:107457531T>A	uc011lvs.1	+	1	829	c.829T>A	c.(829-831)TCG>ACG	p.S277T		NM_001004484	NP_001004484	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D,	277	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTCAGCGCACTCGATTGTGGT	0.388													6	97					0	0	0	0	A	107457531	A	A	107457531	3	1	209	1	0	0	0	0	1	0	0	0	10994	1551	54	5	831	5	OR13D1	9	107457531	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	6562091	107457531	33755900	96	38140											
LPAR1	1902	broad.mit.edu	37	chr9	113704008	113704008	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acaatgaccaccactacccgCcggttgctcatccgtgtgtg	8	9	9	15	3	1	1	1	1	0	0	2	1	2	1	5	1	2	2	5	1	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr9:113704008C>T	uc004bfa.2	-	4	741	c.486G>A	c.(484-486)CGG>CGA	p.R162R	LPAR1_uc011lwm.1_Silent_p.R163R|LPAR1_uc004bfb.2_Silent_p.R162R|LPAR1_uc004bfc.2_Silent_p.R162R|LPAR1_uc011lwn.1_Silent_p.R144R|LPAR1_uc011lwo.1_Silent_p.R163R|LPAR1_uc010mub.2_Silent_p.R162R	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	162	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						CCACTACCCGCCGGTTGCTCA	0.512													22	74					0	0	0	0	T	113704008	T	T	113704008	2	4	209	1	0	0	0	0	0	0	0	1	8954	726	26	4		4	LPAR1	9	113704008	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	6246477	113704008	27509423	97	38141											
RALGPS1	9649	broad.mit.edu	37	chr9	129958852	129958852	+	Frame_Shift_Del	DEL	C	-	-																															agtgtcctagagtcccgcagCccccgaaggggcctggctct																										TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr9:129958852delC	uc004bqo.1	+	13	1404	c.1137delC	c.(1135-1137)AGCfs	p.S379fs	RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	379					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						AGTCCCGCAGCCCCCGAAGGG	0.562													---	---	---								-	129958852	-	-	129958852	7	5	209	1	0	1	0	1	0	0	0	0	13082	738	26	0	1183	0	RALGPS1	9	129958852	Frame_Shift_Del	DEL	C	TCGA-CV-6954-01A-11D-1912-08	16254844	129958852	11254579	98	38142											
CELF2	10659	broad.mit.edu	37	chr10	11047387	11047387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgctgttactatgagaaatGaagagctgcttttaaggtat	12	13	10	6	1	0	3	0	2	0	2	0	4	0	3	1	1	3	5	1	1	6	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr10:11047387G>A	uc001iki.3	+	1	129	c.37G>A	c.(37-39)GAA>AAA	p.E13K	CELF2_uc010qbi.1_5'UTR|CELF2_uc010qbj.1_Missense_Mutation_p.E13K	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	13	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						TATGAGAAATGAAGAGCTGCT	0.398													41	147					0	0	0	0	A	11047387	A	A	11047387	3	1	209	1	0	0	0	0	1	0	0	0	3231	1291	45	2	39	2	CELF2	10	11047387	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08		11047387	124487360	99	38143											
PTER	9317	broad.mit.edu	37	chr10	16526619	16526619	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attaaatcaggagacagaagCcataaaggaagaactgttgt	18	8	10	5	0	1	3	1	0	0	3	1	5	1	4	1	2	2	1	1	2	7	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr10:16526619C>G	uc001iog.1	+	3	443	c.236C>G	c.(235-237)GCC>GGC	p.A79G	PTER_uc001ioh.1_Missense_Mutation_p.A79G|PTER_uc001ioi.1_Missense_Mutation_p.A79G|PTER_uc009xjp.1_Missense_Mutation_p.A79G	NM_030664	NP_109589	Q96BW5	PTER_HUMAN	phosphotriesterase related	79					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			ovary(2)	2						GAGACAGAAGCCATAAAGGAA	0.393													4	74					0	0	0	0	G	16526619	G	G	16526619	3	3	209	1	0	0	0	0	1	0	0	0	12801	739	26	4	238	4	PTER	10	16526619	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	5479232	16526619	119008128	100	38144											
ANKRD30A	91074	broad.mit.edu	37	chr10	37508758	37508758	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaagagaaaaatgaggagaTatttaattacaataaccatt	22	10	6	3	0	0	3	0	1	0	2	0	5	0	3	1	1	2	0	1	1	9	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr10:37508758T>A	uc001iza.1	+	34	4049	c.3950T>A	c.(3949-3951)ATA>AAA	p.I1317K		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1373						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AATGAGGAGATATTTAATTAC	0.274													4	2					0	0	0	0	A	37508758	A	A	37508758	3	1	209	1	0	0	0	0	1	0	0	0	658	1406	49	5	4084	5	ANKRD30A	10	37508758	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	20982139	37508758	98025989	101	38145											
RHOBTB1	9886	broad.mit.edu	37	chr10	62652607	62652607	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgattaacagcttccaggTcggcatagcggagatcaagc	11	8	11	11	3	1	1	1	0	0	1	4	3	2	1	1	3	4	2	1	3	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr10:62652607T>C	uc001jli.2	-	6	881	c.443A>G	c.(442-444)GAC>GGC	p.D148G	RHOBTB1_uc001jlh.2_Missense_Mutation_p.D148G|RHOBTB1_uc001jlj.2_Missense_Mutation_p.D148G|RHOBTB1_uc001jlk.2_Missense_Mutation_p.D148G|RHOBTB1_uc009xpe.1_Intron	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	148	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					AGCTTCCAGGTCGGCATAGCG	0.498													12	47					0	0	0	0	C	62652607	C	C	62652607	3	2	209	1	0	0	0	0	1	0	0	0	13398	1667	58	5	1675	5	RHOBTB1	10	62652607	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	25143849	62652607	72882140	102	38146											
FGFR2	2263	broad.mit.edu	37	chr10	123310907	123310907	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcagcgaaacttgacaGtgttggccgcaggcacagca	10	6	14	11	2	0	1	0	1	0	0	0	2	0	1	1	3	3	5	1	3	1	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr10:123310907G>T	uc010qtk.1	-	5	1168	c.521C>A	c.(520-522)ACT>AAT	p.T174N	FGFR2_uc010qtg.1_Missense_Mutation_p.T174N|FGFR2_uc010qth.1_Missense_Mutation_p.T59N|FGFR2_uc010qti.1_Missense_Mutation_p.T85N|FGFR2_uc010qtj.1_Missense_Mutation_p.T174N|FGFR2_uc010qtl.1_Missense_Mutation_p.T174N|FGFR2_uc010qtm.1_Missense_Mutation_p.T59N|FGFR2_uc001lfl.3_Missense_Mutation_p.T174N|FGFR2_uc001lfm.2_Missense_Mutation_p.T85N|FGFR2_uc001lfn.3_RNA|FGFR2_uc010qtn.1_Missense_Mutation_p.T193N|FGFR2_uc010qto.1_Missense_Mutation_p.T78N|FGFR2_uc001lfo.1_Missense_Mutation_p.T193N|FGFR2_uc010qtp.1_Missense_Mutation_p.T193N|FGFR2_uc010qtq.1_Missense_Mutation_p.T193N	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	174	Ig-like C2-type 2.|Heparin-binding.|Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	AAACTTGACAGTGTTGGCCGC	0.517		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				15	81					1.15088e-07	1.40395e-07	1	0	T	123310907	T	T	123310907	3	4	209	1	0	0	0	0	1	0	0	0	5898	1029	36	4	2256	4	FGFR2	10	123310907	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	60658300	123310907	12223840	103	38147											
OR51B2	79345	broad.mit.edu	37	chr11	5344901	5344901	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggagaagaggatgatcagAcagtctaggaagattgttaa	16	9	13	3	0	2	5	1	1	1	4	2	8	2	7	0	3	0	1	0	3	5	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:5344901A>G	uc001mao.1	-	1	682	c.627T>C	c.(625-627)TGT>TGC	p.C209C	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGATGATCAGACAGTCTAGGA	0.403													5	24					0	0	0	0	G	5344901	G	G	5344901	2	3	209	1	0	0	0	0	0	0	0	1	11143	273	10	5		5	OR51B2	11	5344901	Silent	SNP	A	TCGA-CV-6954-01A-11D-1912-08		5344901	129661615	104	38148											
OR10A2	341276	broad.mit.edu	37	chr11	6891056	6891056	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttctaaccatctacctggTcaccctgatgggaaactgcc	10	11	7	13	0	3	1	1	1	2	0	3	2	3	2	4	2	4	0	4	2	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:6891056T>G	uc001meu.1	+	1	71	c.71T>G	c.(70-72)GTC>GGC	p.V24G		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	24	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ATCTACCTGGTCACCCTGATG	0.448													5	251					0	0	0	0	G	6891056	G	G	6891056	3	3	209	1	0	0	0	0	1	0	0	0	10944	1667	58	5	73	5	OR10A2	11	6891056	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	1546155	6891056	128115460	105	38149											
OR8K5	219453	broad.mit.edu	37	chr11	55927529	55927529	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ataataggaaatagtatttcGatccacaacaaaatttgcca	18	11	5	7	1	0	0	0	0	0	0	2	2	1	1	2	1	2	1	2	1	8	6	rs147577134		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:55927529G>A	uc010rja.1	-	1	265	c.265C>T	c.(265-267)CGA>TGA	p.R89*		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ATAGTATTTCGATCCACAACA	0.393													13	65					0	0	0	0	A	55927529	A	A	55927529	4	1	209	1	0	0	0	0	0	1	0	0	11299	1066	37	1	661	1	OR8K5	11	55927529	Nonsense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	49036473	55927529	79078987	106	38150											
CDC42BPG	55561	broad.mit.edu	37	chr11	64604277	64604277	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagctcccgatggtctgtggGggcgtgcagggcctctggag	4	8	18	11	2	2	0	0	0	2	0	3	2	3	1	2	5	2	2	2	5	0	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:64604277G>C	uc001obs.3	-	11	1318	c.1318C>G	c.(1318-1320)CCC>GCC	p.P440A		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	440	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						TGGTCTGTGGGGGCGTGCAGG	0.701													7	9					0	0	0	0	C	64604277	C	C	64604277	3	2	209	1	0	0	0	0	1	0	0	0	3089	1232	43	4	3445	4	CDC42BPG	11	64604277	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	8676748	64604277	70402239	107	38151											
SUV420H1	51111	broad.mit.edu	37	chr11	67926242	67926242	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctccccctgcgaatgagcaCctctcacaggattctgtctg	7	11	8	15	1	4	1	1	1	4	0	6	3	4	2	3	1	2	1	3	1	1	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:67926242C>A	uc001onm.1	-	11	1827	c.1571G>T	c.(1570-1572)GGT>GTT	p.G524V	SUV420H1_uc009yse.1_Missense_Mutation_p.G110V|SUV420H1_uc001onn.1_Missense_Mutation_p.G352V|SUV420H1_uc009ysf.2_Missense_Mutation_p.G284V	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CGAATGAGCACCTCTCACAGG	0.552													4	129					1.23904e-05	1.45806e-05	1	0	A	67926242	A	A	67926242	3	1	209	1	0	0	0	0	1	0	0	0	15480	507	18	4	1090	4	SUV420H1	11	67926242	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	3321965	67926242	67080274	108	38152											
LRRC32	2615	broad.mit.edu	37	chr11	76371159	76371159	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcagtgccaggacctccAaggaggcctccaggcctccc	7	5	11	18	0	0	0	0	0	0	0	3	2	3	2	8	4	2	1	8	4	1	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:76371159A>T	uc001oxq.3	-	3	1721	c.1478T>A	c.(1477-1479)TTG>TAG	p.L493*	LRRC32_uc001oxr.3_Nonsense_Mutation_p.L493*|LRRC32_uc010rsf.1_Intron	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	493	Extracellular (Potential).|LRR 18.					integral to plasma membrane					0						CAGGACCTCCAAGGAGGCCTC	0.652													7	31					0	0	0	0	T	76371159	T	T	76371159	4	4	209	1	0	0	0	0	0	1	0	0	9037	131	5	5	514	5	LRRC32	11	76371159	Nonsense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	8444917	76371159	58635357	109	38153											
GRIA4	2893	broad.mit.edu	37	chr11	105623796	105623796	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgacctcattctgcagcgccTtacatatctccctcatcaca	9	12	4	16	1	5	1	3	1	2	0	6	1	5	1	3	0	3	1	3	0	2	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:105623796T>A	uc001pix.2	+	4	783	c.337T>A	c.(337-339)TTA>ATA	p.L113I	GRIA4_uc001piu.1_Missense_Mutation_p.L113I|GRIA4_uc001piw.2_Missense_Mutation_p.L113I|GRIA4_uc001piv.2_Missense_Mutation_p.L113I|GRIA4_uc009yxk.1_Missense_Mutation_p.L113I	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	113	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	CTGCAGCGCCTTACATATCTC	0.463													18	72					0	0	0	0	A	105623796	A	A	105623796	3	1	209	1	0	0	0	0	1	0	0	0	6809	1606	56	5	347	5	GRIA4	11	105623796	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	29252637	105623796	29382720	110	38154											
TMPRSS13	84000	broad.mit.edu	37	chr11	117789510	117789510	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcccagctggagatgcctggGctggagatgctccagctgaa	8	8	14	11	0	0	3	0	1	0	2	2	5	2	3	3	3	4	4	3	3	1	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:117789510G>C	uc001prs.1	-	2	158	c.65C>G	c.(64-66)GCC>GGC	p.A22G	TMPRSS13_uc009yzr.1_5'UTR|TMPRSS13_uc001prt.1_5'UTR|TMPRSS13_uc001pru.1_Missense_Mutation_p.A22G	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	22	4 X 5 AA repeats of T-P-P-G-R.|1-2.|12 X 5 AA repeats of A-S-P-A-[GLQR].|Cytoplasmic (Potential).|Ala-rich.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			pancreas(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		AGATGCCTGGGCTGGAGATGC	0.627													9	52					0	0	0	0	C	117789510	C	C	117789510	3	2	209	1	0	0	0	0	1	0	0	0	16311	1203	42	4	1686	4	TMPRSS13	11	117789510	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	12165714	117789510	17217006	111	38155											
MLL	4297	broad.mit.edu	37	chr11	118377362	118377362	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccctgacctcaggcacaggGtgagagatccaaatactagc	12	7	10	12	0	1	3	1	2	0	1	3	4	3	3	3	2	2	1	3	2	3	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:118377362G>T	uc001pta.2	+	27	10768	c.10745_splice	c.e27+1	p.G3582_splice	MLL_uc001ptb.2_Splice_Site_p.G3585_splice	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia						apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CAGGCACAGGGTGAGAGATCC	0.483			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								6	78					0.00116845	0.00129027	1	0	T	118377362	T	T	118377362	5	4	209	1	0	0	0	0	0	0	1	0	9673	1275	44	4	10852	4	MLL	11	118377362	Splice_Site	SNP	G	TCGA-CV-6954-01A-11D-1912-08	587852	118377362	16629154	112	38156											
ROBO4	54538	broad.mit.edu	37	chr11	124763789	124763789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccctagctcggcgccggcGgtggatacacacggcggtgc	6	5	15	15	6	0	0	0	0	0	0	1	1	0	1	2	6	3	1	2	6	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:124763789G>A	uc001qbg.2	-	9	1611	c.1471C>T	c.(1471-1473)CGC>TGC	p.R491C	ROBO4_uc010sas.1_Missense_Mutation_p.R346C|ROBO4_uc001qbh.2_Missense_Mutation_p.R381C|ROBO4_uc001qbi.2_Missense_Mutation_p.R49C|ROBO4_uc010sat.1_Missense_Mutation_p.R49C	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	491					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CGGCGCCGGCGGTGGATACAC	0.647													4	17					0	0	0	0	A	124763789	A	A	124763789	3	1	209	1	0	0	0	0	1	0	0	0	13581	1116	39	1	1592	1	ROBO4	11	124763789	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	6386427	124763789	10242727	113	38157											
NCAPD3	23310	broad.mit.edu	37	chr11	134027943	134027943	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagaattcaggattgcaaTggtgctcagggacatgggcc	11	8	14	8	0	2	1	2	0	0	1	2	4	2	3	1	4	2	2	1	4	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr11:134027943T>C	uc001qhd.1	-	31	4660	c.4054A>G	c.(4054-4056)ATT>GTT	p.I1352V	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA|NCAPD3_uc001qhc.1_Missense_Mutation_p.I302V	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1352					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		AGGATTGCAATGGTGCTCAGG	0.552													38	137					0	0	0	0	C	134027943	C	C	134027943	3	2	209	1	0	0	0	0	1	0	0	0	10260	1464	51	5	462	5	NCAPD3	11	134027943	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	9264154	134027943	978573	114	38158											
C12orf4	57102	broad.mit.edu	37	chr12	4599038	4599038	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggggaagcatgttactaaGttgataaaacatttcttcag	13	13	9	6	0	2	1	1	1	1	0	2	2	2	2	0	2	3	3	0	2	5	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr12:4599038G>C	uc001qms.2	-	14	1682	c.1594C>G	c.(1594-1596)CTT>GTT	p.L532V	C12orf4_uc001qmt.2_Missense_Mutation_p.L532V	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	532											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		ATGTTACTAAGTTGATAAAAC	0.303													30	35					0	0	0	0	C	4599038	C	C	4599038	3	2	209	1	0	0	0	0	1	0	0	0	1691	1029	36	4	68	4	C12orf4	12	4599038	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08		4599038	129252857	115	38159											
CD9	928	broad.mit.edu	37	chr12	6342628	6342628	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgaaatagctgcggccatCtggggatattcccacaagga	12	9	11	9	1	1	1	0	1	1	0	2	3	2	3	2	4	2	1	2	4	4	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr12:6342628C>G	uc001qnp.1	+	5	768	c.324C>G	c.(322-324)ATC>ATG	p.I108M	CD9_uc010sev.1_Missense_Mutation_p.I108M|CD9_uc001qnq.1_Missense_Mutation_p.I108M	NM_001769	NP_001760	P21926	CD9_HUMAN	CD9 antigen	108	Helical; (Potential).				cell adhesion|cellular component movement|fusion of sperm to egg plasma membrane|paranodal junction assembly|platelet activation|platelet degranulation	integral to plasma membrane|platelet alpha granule membrane				ovary(1)	1						CTGCGGCCATCTGGGGATATT	0.557													29	38					0	0	0	0	G	6342628	G	G	6342628	3	3	209	1	0	0	0	0	1	0	0	0	3061	903	32	2	338	2	CD9	12	6342628	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	1743590	6342628	127509267	116	38160											
PZP	5858	broad.mit.edu	37	chr12	9313713	9313713	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctcagacacattagcacCtttagaaacagacagcccat	14	8	6	13	0	1	3	1	0	0	3	1	3	1	3	2	0	4	2	2	0	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr12:9313713C>T	uc001qvl.2	-	23	2818	c.2789_splice	c.e23-1	p.G930_splice	PZP_uc009zgl.2_Splice_Site_p.G716_splice|PZP_uc010sgo.1_Splice_Site|PZP_uc009zgm.1_Intron	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						ACATTAGCACCTTTAGAAACA	0.318													7	57					0	0	0	0	T	9313713	T	T	9313713	5	4	209	1	0	0	0	0	0	0	1	0	12934	695	24	4	1716	4	PZP	12	9313713	Splice_Site	SNP	C	TCGA-CV-6954-01A-11D-1912-08	2971085	9313713	124538182	117	38161											
C12orf35	55196	broad.mit.edu	37	chr12	32133942	32133942	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attaccaccactgtatcctaAaagccagccaccttttttgc	11	12	4	14	0	0	0	0	0	0	0	1	0	1	0	6	0	4	1	6	0	4	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr12:32133942A>T	uc001rks.2	+	4	467	c.53A>T	c.(52-54)AAA>ATA	p.K18I		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	18										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CTGTATCCTAAAAGCCAGCCA	0.348													19	30					0	0	0	0	T	32133942	T	T	32133942	3	4	209	1	0	0	0	0	1	0	0	0	1688	14	1	5	55	5	C12orf35	12	32133942	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	22820229	32133942	101717953	118	38162											
METAP2	10988	broad.mit.edu	37	chr12	95887871	95887871	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actacaagtgaagaaaagaaAgcattagatcaggcaagtga	20	6	10	5	0	1	5	1	2	0	3	1	5	1	5	0	1	2	2	0	1	8	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr12:95887871A>G	uc001tec.2	+	5	602	c.468A>G	c.(466-468)AAA>AAG	p.K156K	METAP2_uc010suv.1_Silent_p.K133K|METAP2_uc009ztd.2_Silent_p.K120K|METAP2_uc001ted.2_Silent_p.K155K|METAP2_uc001tef.2_Silent_p.K133K|METAP2_uc001tee.2_RNA	NM_006838	NP_006829	P50579	AMPM2_HUMAN	methionyl aminopeptidase 2	156					N-terminal protein amino acid modification|peptidyl-methionine modification|protein processing|proteolysis	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0					L-Methionine(DB00134)	AAGAAAAGAAAGCATTAGATC	0.403													3	54					0	0	0	0	G	95887871	G	G	95887871	2	3	209	1	0	0	0	0	0	0	0	1	9540	69	3	5		5	METAP2	12	95887871	Silent	SNP	A	TCGA-CV-6954-01A-11D-1912-08	63753929	95887871	37964024	119	38163											
APAF1	317	broad.mit.edu	37	chr12	99042256	99042256	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttttaacaatatcagaagAggaaaaagtaagaaatgagg	21	9	9	2	0	1	4	1	1	0	3	1	5	1	5	0	2	1	1	0	2	8	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr12:99042256A>T	uc001tfz.2	+	2	696	c.119A>T	c.(118-120)GAG>GTG	p.E40V	APAF1_uc001tfy.2_Missense_Mutation_p.E40V|APAF1_uc001tga.2_Missense_Mutation_p.E40V|APAF1_uc001tgb.2_Missense_Mutation_p.E40V|APAF1_uc001tgc.2_Missense_Mutation_p.E40V	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	40	CARD.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	ATATCAGAAGAGGAAAAAGTA	0.348													4	112					0	0	0	0	T	99042256	T	T	99042256	3	4	209	1	0	0	0	0	1	0	0	0	755	304	11	5	121	5	APAF1	12	99042256	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	3154385	99042256	34809639	120	38164											
UTP20	27340	broad.mit.edu	37	chr12	101732715	101732715	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatagagcacaagtcagtaaAgagcttggcattctttcaaa	16	10	8	7	0	3	2	2	0	1	2	3	2	3	2	0	1	2	4	0	1	6	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr12:101732715A>G	uc001tia.1	+	31	4149	c.3993A>G	c.(3991-3993)AAA>AAG	p.K1331K		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1331					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						AAGTCAGTAAAGAGCTTGGCA	0.299													19	36					0	0	0	0	G	101732715	G	G	101732715	2	3	209	1	0	0	0	0	0	0	0	1	17167	69	3	5		5	UTP20	12	101732715	Silent	SNP	A	TCGA-CV-6954-01A-11D-1912-08	2690459	101732715	32119180	121	38165											
C12orf52	84934	broad.mit.edu	37	chr12	113629453	113629453	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccccagcactggtcatccagCcaccagtgccccccacacaa	10	4	6	21	0	1	0	1	0	0	0	2	0	2	0	8	1	3	1	8	1	1	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr12:113629453C>G	uc001tur.1	+	4	1109	c.641C>G	c.(640-642)GCC>GGC	p.A214G	C12orf52_uc009zwg.1_Missense_Mutation_p.A211G|C12orf52_uc001tus.1_Missense_Mutation_p.A214G|C12orf52_uc001tut.1_Missense_Mutation_p.A238G	NM_032848	NP_116237	Q96K30	RITA_HUMAN	hypothetical protein LOC84934	214	Interaction with tubulin.				negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding				0						GGTCATCCAGCCACCAGTGCC	0.602													3	62					0	0	0	0	G	113629453	G	G	113629453	3	3	209	1	0	0	0	0	1	0	0	0	1703	739	26	4	647	4	C12orf52	12	113629453	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	11896738	113629453	20222442	122	38166											
TMEM120B	144404	broad.mit.edu	37	chr12	122213541	122213541	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtactggcgttcaccttcctCatcctcttcctcggcaactt	5	14	6	16	2	3	0	2	0	1	0	7	0	6	0	4	2	2	3	4	2	2	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr12:122213541C>T	uc001ubc.3	+	12	1077	c.933C>T	c.(931-933)CTC>CTT	p.L311L	TMEM120B_uc009zxh.2_3'UTR|TMEM120B_uc001uba.1_5'Flank	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	311	Helical; (Potential).					integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		TCACCTTCCTCATCCTCTTCC	0.612											OREG0022207	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	60					0	0	0	0	T	122213541	T	T	122213541	2	4	209	1	0	0	0	0	0	0	0	1	16100	813	29	2		2	TMEM120B	12	122213541	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	8584088	122213541	11638354	123	38167											
DCLK1	9201	broad.mit.edu	37	chr13	36382386	36382386	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaatcggaaacattatccCagtatggagaaggaaagtcc	16	7	10	8	1	0	2	0	0	0	2	3	5	2	4	2	3	1	1	2	3	6	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr13:36382386C>A	uc001uvf.2	-	14	2071	c.1838G>T	c.(1837-1839)TGG>TTG	p.W613L	DCLK1_uc001uve.3_Missense_Mutation_p.W306L|DCLK1_uc010teh.1_Missense_Mutation_p.W306L|DCLK1_uc010abk.2_Missense_Mutation_p.W133L	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	613	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		AACATTATCCCAGTATGGAGA	0.428													6	139					8.12818e-05	9.32939e-05	1	0	A	36382386	A	A	36382386	3	1	209	1	0	0	0	0	1	0	0	0	4308	595	21	4	371	4	DCLK1	13	36382386	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08		36382386	78787492	124	38168											
RBM26	64062	broad.mit.edu	37	chr13	79896555	79896555	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tactggtttattccatgccaGttttagatcttgccctttga	7	18	7	9	0	1	2	0	1	1	1	2	2	2	2	3	1	3	2	3	1	3	8			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr13:79896555G>C	uc001vkz.2	-	21	2883	c.2869C>G	c.(2869-2871)CTG>GTG	p.L957V	RBM26_uc001vky.2_Missense_Mutation_p.L928V|RBM26_uc001vla.2_Missense_Mutation_p.L931V|RBM26_uc010tia.1_Missense_Mutation_p.L312V|RBM26_uc001vkx.2_Missense_Mutation_p.L667V	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	955	RRM 2.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TTCCATGCCAGTTTTAGATCT	0.299													21	17					0	0	0	0	C	79896555	C	C	79896555	3	2	209	1	0	0	0	0	1	0	0	0	13191	1020	36	4	168	4	RBM26	13	79896555	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	43514169	79896555	35273323	125	38169											
PRKD1	5587	broad.mit.edu	37	chr14	30046531	30046531	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctagcacttggattgatCaggtgtgtggggtactgcag	7	12	16	6	0	1	1	1	1	0	0	1	2	1	2	0	5	3	4	0	5	2	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr14:30046531C>A	uc001wqh.2	-	18	2833	c.2652G>T	c.(2650-2652)CTG>CTT	p.L884L		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	884					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TTGGATTGATCAGGTGTGTGG	0.527													34	101					1.22384e-17	1.57543e-17	1	0	A	30046531	A	A	30046531	2	1	209	1	0	0	0	0	0	0	0	1	12580	813	29	2		2	PRKD1	14	30046531	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08		30046531	77303009	126	38170											
ZFYVE26	23503	broad.mit.edu	37	chr14	68272336	68272337	+	Splice_Site	DNP	CT	AC	AC																															aacaatgttagtgctgttacCtgtaagtcaaagaaagctgt																										TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr14:68272336_68272337CT>AC	uc001xka.2	-	7	1157	c.1018_splice	c.e7-1	p.V340_splice	ZFYVE26_uc010tsz.1_Splice_Site|ZFYVE26_uc001xkc.3_Splice_Site_p.V340_splice|ZFYVE26_uc010tta.1_Splice_Site_p.V340_splice	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26						cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GTGCTGTTACCTGTAAGTCAAA	0.431													7	54					0	0	0	0	AC	68272337	AC	AC	68272336	5	1	209	1	0	0	0	0	0	0	1	0	17735	695	24	4	6746	4	ZFYVE26	14	68272336	Splice_Site	DNP	CT	TCGA-CV-6954-01A-11D-1912-08	38225805	68272336	39077204	127	38171											
DLST	1743	broad.mit.edu	37	chr14	75369021	75369021	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaggatcccagagtcctcctCctggatctttaggaggaacc	9	9	11	12	0	1	1	0	0	1	1	5	6	5	5	5	4	1	0	5	4	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr14:75369021C>G	uc001xqv.2	+	15	1413	c.1350C>G	c.(1348-1350)CTC>CTG	p.L450L	DLST_uc001xqt.2_Silent_p.L366L|DLST_uc010tuw.1_Silent_p.L364L	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	450					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		GAGTCCTCCTCCTGGATCTTT	0.547													15	56					0	0	0	0	G	75369021	G	G	75369021	2	3	209	1	0	0	0	0	0	0	0	1	4591	842	30	2		2	DLST	14	75369021	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	7096685	75369021	31980519	128	38172											
SERPINA5	5104	broad.mit.edu	37	chr14	95058474	95058474	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggacaatattcactttcagGtcggcccgcctgaactctca	9	10	9	13	2	3	1	3	1	1	0	5	2	3	2	2	3	1	0	2	3	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr14:95058474G>T	uc001ydm.2	+	6	1329	c.1119G>T	c.(1117-1119)AGG>AGT	p.R373S	SERPINA3_uc001ydo.3_Splice_Site	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	373		Reactive bond.			fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	TCACTTTCAGGTCGGCCCGCC	0.562													9	442					0.000274275	0.000310224	1	0	T	95058474	T	T	95058474	3	4	209	1	0	0	0	0	1	0	0	0	14157	1252	44	4	1133	4	SERPINA5	14	95058474	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	19689453	95058474	12291066	129	38173											
PPP2R5C	5527	broad.mit.edu	37	chr14	102384193	102384193	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtgtatagtcaagccagcaCcatgagcattccggttgcaa	12	9	10	10	1	1	1	1	1	0	0	2	1	2	1	3	1	4	5	3	1	4	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr14:102384193C>T	uc001yko.2	+	13	1492	c.1352C>T	c.(1351-1353)ACC>ATC	p.T451I	PPP2R5C_uc010txr.1_Missense_Mutation_p.T482I|PPP2R5C_uc001ykk.2_Intron|PPP2R5C_uc001ykp.2_Intron	NM_002719	NP_002710	Q13362	2A5G_HUMAN	gamma isoform of regulatory subunit B56, protein	451					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein binding|protein phosphatase type 2A regulator activity|protein phosphatase type 2A regulator activity			ovary(1)|breast(1)	2						CAAGCCAGCACCATGAGCATT	0.502													45	108					0	0	0	0	T	102384193	T	T	102384193	3	4	209	1	0	0	0	0	1	0	0	0	12454	507	18	4	1795	4	PPP2R5C	14	102384193	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	7325719	102384193	4965347	130	38174											
HSP90AA1	3320	broad.mit.edu	37	chr14	102552329	102552329	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgatcaagtcagccttggTcattccaattccagtatcca	11	13	6	11	0	3	1	3	1	0	0	6	1	6	1	4	1	1	1	4	1	3	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr14:102552329T>C	uc001yku.3	-	3	485	c.295A>G	c.(295-297)ACC>GCC	p.T99A	HSP90AA1_uc001ykv.3_Missense_Mutation_p.T221A|HSP90AA1_uc001ykw.1_Intron|HSP90AA1_uc001ykx.1_Missense_Mutation_p.T88A	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	99					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	TCAGCCTTGGTCATTCCAATT	0.433													4	85					0	0	0	0	C	102552329	C	C	102552329	3	2	209	1	0	0	0	0	1	0	0	0	7440	1667	58	5	1939	5	HSP90AA1	14	102552329	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	168136	102552329	4797211	131	38175											
BAHD1	22893	broad.mit.edu	37	chr15	40756083	40756083	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccggagccagccatccgAaagagctaccaggcggtaga	12	3	14	12	3	0	2	0	0	0	2	1	5	1	3	5	3	5	2	5	3	3	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr15:40756083A>G	uc001zlu.2	+	4	1910	c.1839A>G	c.(1837-1839)CGA>CGG	p.R613R	BAHD1_uc001zlt.2_Silent_p.R612R|BAHD1_uc010bbp.1_Silent_p.R612R|BAHD1_uc001zlv.2_Silent_p.R613R	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	613					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CAGCCATCCGAAAGAGCTACC	0.552													7	14					0	0	0	0	G	40756083	G	G	40756083	2	3	209	1	0	0	0	0	0	0	0	1	1299	233	9	5		5	BAHD1	15	40756083	Silent	SNP	A	TCGA-CV-6954-01A-11D-1912-08		40756083	61775309	132	38176											
RPAP1	26015	broad.mit.edu	37	chr15	41814044	41814044	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggccataccatgatagaggGcagcatgggtggctggcagt	10	7	16	8	0	0	2	0	1	0	1	0	2	0	2	2	5	2	4	2	5	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr15:41814044G>C	uc001zod.2	-	21	3054	c.2930C>G	c.(2929-2931)GCC>GGC	p.A977G	RPAP1_uc001zoc.2_5'UTR	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	977	Leu-rich.					nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		ATGATAGAGGGCAGCATGGGT	0.602													3	26					0	0	0	0	C	41814044	C	C	41814044	3	2	209	1	0	0	0	0	1	0	0	0	13606	1203	42	4	1271	4	RPAP1	15	41814044	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	1057961	41814044	60717348	133	38177											
MAP1A	4130	broad.mit.edu	37	chr15	43819557	43819557	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccacaccctatcctgatgaGagaagctttcagtatgcaga	12	9	8	12	0	1	4	1	2	0	2	2	5	2	4	3	0	2	3	3	0	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr15:43819557G>C	uc001zrt.2	+	4	6353	c.5886G>C	c.(5884-5886)GAG>GAC	p.E1962D		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1962						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	ATCCTGATGAGAGAAGCTTTC	0.562													24	62					0	0	0	0	C	43819557	C	C	43819557	3	2	209	1	0	0	0	0	1	0	0	0	9280	933	33	2	5888	2	MAP1A	15	43819557	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	2005513	43819557	58711835	134	38178											
SLC12A1	6557	broad.mit.edu	37	chr15	48500299	48500299	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtgggcccaaggtcaaccGacccagcctgcttgagattc	9	7	11	14	1	1	1	1	1	0	1	2	3	1	1	4	2	3	1	4	2	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr15:48500299G>A	uc001zwn.3	+	2	599	c.383G>A	c.(382-384)CGA>CAA	p.R128Q	SLC12A1_uc010uew.1_Intron|SLC12A1_uc010bem.2_Missense_Mutation_p.R128Q|SLC12A1_uc010uex.1_Missense_Mutation_p.R128Q	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	128	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	AAGGTCAACCGACCCAGCCTG	0.473													13	48					0	0	0	0	A	48500299	A	A	48500299	3	1	209	1	0	0	0	0	1	0	0	0	14447	1058	37	1	385	1	SLC12A1	15	48500299	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	4680742	48500299	54031093	135	38179											
WDR72	256764	broad.mit.edu	37	chr15	53998227	53998227	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtaccttgtaaaaaggctcTttcctttcattcatgtagcc	10	15	6	10	0	3	0	2	0	1	0	4	0	4	0	3	1	2	4	3	1	5	7			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr15:53998227T>C	uc002acj.2	-	10	1041	c.999A>G	c.(997-999)AAA>AAG	p.K333K	WDR72_uc010bfi.1_Silent_p.K333K	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	333	WD 4.									lung(1)|skin(1)	2				all cancers(107;0.0511)		AAAAAGGCTCTTTCCTTTCAT	0.403													4	31					0	0	0	0	C	53998227	C	C	53998227	2	2	209	1	0	0	0	0	0	0	0	1	17390	1606	56	5		5	WDR72	15	53998227	Silent	SNP	T	TCGA-CV-6954-01A-11D-1912-08	5497928	53998227	48533165	136	38180											
ARNT2	9915	broad.mit.edu	37	chr15	80762647	80762647	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acatggtccccacatgcagcGcactggctcggaagccagac	10	5	11	15	2	0	1	0	0	0	1	2	2	1	2	3	3	3	3	3	3	1	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr15:80762647G>T	uc002bfr.2	+	4	449	c.283G>T	c.(283-285)GCA>TCA	p.A95S	ARNT2_uc002bfq.2_Missense_Mutation_p.A95S|ARNT2_uc010unm.1_Missense_Mutation_p.A84S|ARNT2_uc002bfs.2_Missense_Mutation_p.A84S	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	95	Helix-loop-helix motif.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			CACATGCAGCGCACTGGCTCG	0.552													13	31					1.36491e-13	1.73784e-13	1	0	T	80762647	T	T	80762647	3	4	209	1	0	0	0	0	1	0	0	0	968	1087	38	3	297	3	ARNT2	15	80762647	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	26764420	80762647	21768745	137	38181											
ARNT2	9915	broad.mit.edu	37	chr15	80872870	80872870	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtggcatggacagggagtCgtccgccctttccgggacag	7	7	16	11	3	0	0	0	0	0	0	3	3	2	3	3	5	0	1	3	5	0	1	rs144530385		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr15:80872870C>T	uc002bfr.2	+	16	1898	c.1732C>T	c.(1732-1734)CGT>TGT	p.R578C	ARNT2_uc010unm.1_Missense_Mutation_p.R567C|ARNT2_uc002bfs.2_Missense_Mutation_p.R567C	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	578					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			GACAGGGAGTCGTCCGCCCTT	0.567													15	39					0	0	0	0	T	80872870	T	T	80872870	3	4	209	1	0	0	0	0	1	0	0	0	968	884	31	1	1794	1	ARNT2	15	80872870	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	110223	80872870	21658522	138	38182											
MAN2A2	4122	broad.mit.edu	37	chr15	91447520	91447520	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctctacctcatgctggaccGagtgcaacacgatcccaccc	9	7	8	17	2	2	0	1	0	1	0	3	3	3	1	4	1	4	3	4	1	2	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr15:91447520G>A	uc010bnz.2	+	2	198	c.83G>A	c.(82-84)CGA>CAA	p.R28Q	MAN2A2_uc010boa.2_Missense_Mutation_p.R70Q|MAN2A2_uc002bqc.2_Missense_Mutation_p.R28Q|MAN2A2_uc010uql.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	28	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			ATGCTGGACCGAGTGCAACAC	0.547													23	76					0	0	0	0	A	91447520	A	A	91447520	3	1	209	1	0	0	0	0	1	0	0	0	9268	1058	37	1	85	1	MAN2A2	15	91447520	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	10574650	91447520	11083872	139	38183											
CACNA1H	8912	broad.mit.edu	37	chr16	1262016	1262016	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcatcgtcagcttcttcgTgctcaacatgttcgtgggcg	5	13	11	12	4	4	0	3	0	1	0	7	0	4	0	0	1	3	4	0	1	1	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr16:1262016T>C	uc002cks.2	+	25	4885	c.4637T>C	c.(4636-4638)GTG>GCG	p.V1546A	CACNA1H_uc002ckt.2_Missense_Mutation_p.V1546A|CACNA1H_uc002cku.2_Missense_Mutation_p.V252A|CACNA1H_uc010brj.2_Missense_Mutation_p.V252A|CACNA1H_uc002ckv.2_Missense_Mutation_p.V252A	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1546	Helical; Name=S6 of repeat III; (Potential).|III.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	AGCTTCTTCGTGCTCAACATG	0.642													98	175					0	0	0	0	C	1262016	C	C	1262016	3	2	209	1	0	0	0	0	1	0	0	0	2557	1696	59	5	4731	5	CACNA1H	16	1262016	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08		1262016	89092737	140	38184											
UMOD	7369	broad.mit.edu	37	chr16	20347992	20347992	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgtgatgggacccaagtTcaggacacgggattgatcta	10	9	13	9	2	2	2	1	2	1	0	2	5	2	5	2	3	0	1	2	3	2	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr16:20347992T>C	uc002dgz.2	-	9	1927	c.1798A>G	c.(1798-1800)AAC>GAC	p.N600D	UMOD_uc002dha.2_Missense_Mutation_p.N600D|UMOD_uc002dhb.2_Missense_Mutation_p.N633D	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	600					cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						GGACCCAAGTTCAGGACACGG	0.527													6	47					0	0	0	0	C	20347992	C	C	20347992	3	2	209	1	0	0	0	0	1	0	0	0	17047	1783	62	5	136	5	UMOD	16	20347992	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	19085976	20347992	70006761	141	38185											
LOC100132247	100132247	broad.mit.edu	37	chr16	22545874	22545874	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcagctcactgcccttccaCcctcagcagatgataatatc	10	10	6	15	0	3	2	3	1	0	1	5	2	4	2	3	0	3	2	3	0	2	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr16:22545874C>T	uc010bxg.2	+	9	1752	c.1570C>T	c.(1570-1572)CCC>TCC	p.P524S	LOC100132247_uc010vbv.1_Missense_Mutation_p.P524S|LOC100132247_uc010vbw.1_Intron|LOC100132247_uc010bxi.2_Missense_Mutation_p.P505S|LOC100132247_uc010bxk.2_Missense_Mutation_p.P341S|uc010vbx.1_5'Flank	NM_001135865	NP_001129337	A8MRT5	K220L_HUMAN	hypothetical protein LOC100132247	524	Pro-rich.					integral to membrane					0						TGCCCTTCCACCCTCAGCAGA	0.577													22	545					0	0	0	0	T	22545874	T	T	22545874	3	4	209	1	0	0	0	0	1	0	0	0	8912	507	18	4	1596	4	LOC100132247	16	22545874	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	2197882	22545874	67808879	142	38186											
TNRC6A	27327	broad.mit.edu	37	chr16	24802394	24802394	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggaagatgattctgctgctAcaggaatggtcaagagcaat	13	9	13	6	0	2	3	1	1	1	2	2	5	2	5	0	3	4	3	0	3	5	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr16:24802394A>G	uc002dmm.2	+	6	2545	c.2431A>G	c.(2431-2433)ACA>GCA	p.T811A	TNRC6A_uc010bxs.2_Missense_Mutation_p.T558A|TNRC6A_uc010vcc.1_Missense_Mutation_p.T558A|TNRC6A_uc002dmn.2_Missense_Mutation_p.T558A|TNRC6A_uc002dmo.2_Missense_Mutation_p.T558A	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	811	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TTCTGCTGCTACAGGAATGGT	0.517													9	29					0	0	0	0	G	24802394	G	G	24802394	3	3	209	1	0	0	0	0	1	0	0	0	16406	391	14	5	2453	5	TNRC6A	16	24802394	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	2256520	24802394	65552359	143	38187											
NOD2	64127	broad.mit.edu	37	chr16	50733835	50733835	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtatgaatgtgatgaaatCaggttgccgatcttcacacc	12	11	9	9	1	3	3	2	3	1	0	3	4	3	3	2	1	1	2	2	1	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr16:50733835C>T	uc002egm.1	+	2	615	c.510C>T	c.(508-510)ATC>ATT	p.I170I	NOD2_uc010cbj.1_Silent_p.I143I|NOD2_uc010cbk.1_Silent_p.I143I|NOD2_uc002egl.1_5'UTR	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	170	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				GTGATGAAATCAGGTTGCCGA	0.552													19	41					0	0	0	0	T	50733835	T	T	50733835	2	4	209	1	0	0	0	0	0	0	0	1	10571	816	29	2		2	NOD2	16	50733835	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	25931441	50733835	39620918	144	38188											
RANBP10	57610	broad.mit.edu	37	chr16	67778258	67778258	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgacacagcagccgatcacGtctcctgtggtgaatgtggg	8	10	13	10	2	2	2	1	2	1	0	3	3	2	2	2	2	2	1	2	2	1	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr16:67778258G>A	uc002eud.2	-	4	617	c.501C>T	c.(499-501)GAC>GAT	p.D167D	RANBP10_uc010ceo.2_Translation_Start_Site|RANBP10_uc010vju.1_Intron|RANBP10_uc010vjv.1_Silent_p.D50D|RANBP10_uc010vjx.1_Silent_p.D167D|RANBP10_uc010vjy.1_Silent_p.D35D	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	167	B30.2/SPRY.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		AGCCGATCACGTCTCCTGTGG	0.547													19	79					0	0	0	0	A	67778258	A	A	67778258	2	1	209	1	0	0	0	0	0	0	0	1	13091	1136	40	1		1	RANBP10	16	67778258	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	17044423	67778258	22576495	145	38189											
TSNAXIP1	55815	broad.mit.edu	37	chr16	67860602	67860602	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgatcccgcagaaagagaCgttcccagatttcttcttca	10	11	7	13	3	3	3	1	0	2	3	6	5	5	3	2	0	0	2	2	0	1	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr16:67860602C>A	uc002euj.2	+	12	1641	c.1247C>A	c.(1246-1248)ACG>AAG	p.T416K	TSNAXIP1_uc010vjz.1_Missense_Mutation_p.T293K|TSNAXIP1_uc002euf.3_Missense_Mutation_p.T149K|TSNAXIP1_uc010vka.1_Missense_Mutation_p.T470K|TSNAXIP1_uc010vkb.1_Missense_Mutation_p.T401K|TSNAXIP1_uc002eug.3_Missense_Mutation_p.T124K|TSNAXIP1_uc002euh.3_Missense_Mutation_p.T124K|TSNAXIP1_uc002eui.3_Missense_Mutation_p.T124K|TSNAXIP1_uc002euk.2_Missense_Mutation_p.T149K	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	416					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		CAGAAAGAGACGTTCCCAGAT	0.493													42	83					3.43241e-23	4.44307e-23	1	0	A	67860602	A	A	67860602	3	1	209	1	0	0	0	0	1	0	0	0	16699	536	19	3	1285	3	TSNAXIP1	16	67860602	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	82344	67860602	22494151	146	38190											
COG4	25839	broad.mit.edu	37	chr16	70548314	70548314	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgagtatgtgctgcagcctgCtcataatcttcactcctcaa	9	13	7	12	0	4	1	3	1	1	0	5	1	5	1	2	0	4	4	2	0	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr16:70548314C>A	uc002ezc.2	-	4	479	c.468G>T	c.(466-468)GAG>GAT	p.E156D	COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.E156D|COG4_uc002eze.2_5'UTR	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	152	Interacts with STX5.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				CTGCAGCCTGCTCATAATCTT	0.353													11	50					3.07112e-06	3.65087e-06	1	0	A	70548314	A	A	70548314	3	1	209	1	0	0	0	0	1	0	0	0	3675	796	28	4	1965	4	COG4	16	70548314	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	2687712	70548314	19806439	147	38191											
HP	3240	broad.mit.edu	37	chr16	72094609	72094609	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctggcatgtctaagtaccaAgaagacacctgctatggcga	12	8	11	10	1	1	2	0	0	1	2	1	3	1	2	2	2	2	4	2	2	5	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr16:72094609A>G	uc002fbr.3	+	7	1085	c.1041A>G	c.(1039-1041)CAA>CAG	p.Q347Q	TXNL4B_uc010cgl.2_Intron|HP_uc010cgm.2_Silent_p.Q288Q|HP_uc002fbt.3_Silent_p.Q288Q|HP_uc002fbu.1_Silent_p.Q85Q|HP_uc002fbv.3_Silent_p.Q258Q|HP_uc002fbw.3_Silent_p.Q169Q|HP_uc002fbx.3_Silent_p.Q169Q|HPR_uc002fby.2_5'Flank	NM_005143	NP_005134	P00738	HPT_HUMAN	haptoglobin isoform 1 preproprotein	347	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity				0		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		CTAAGTACCAAGAAGACACCT	0.537													8	115					0	0	0	0	G	72094609	G	G	72094609	2	3	209	1	0	0	0	0	0	0	0	1	7366	69	3	5		5	HP	16	72094609	Silent	SNP	A	TCGA-CV-6954-01A-11D-1912-08	1546295	72094609	18260144	148	38192											
TUBB3	10381	broad.mit.edu	37	chr16	90001910	90001910	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggatccccaacaacgtgaagGtggccgtgtgtgacatcccg	9	7	13	12	3	0	2	0	2	0	0	2	3	2	3	4	3	2	0	4	3	3	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr16:90001910G>T	uc002fph.1	+	4	1116	c.1051G>T	c.(1051-1053)GTG>TTG	p.V351L	TUBB3_uc002fpf.2_Missense_Mutation_p.V698L|TUBB3_uc010ciz.1_Missense_Mutation_p.V279L|TUBB3_uc002fpg.1_Missense_Mutation_p.V205L|TUBB3_uc002fpi.1_Missense_Mutation_p.V279L|TUBB3_uc002fpj.1_Missense_Mutation_p.V279L|TUBB3_uc010cjb.1_Missense_Mutation_p.V205L|TUBB3_uc002fpk.1_Missense_Mutation_p.V205L	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	351					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CAACGTGAAGGTGGCCGTGTG	0.612													15	250					0.000308642	0.000347409	1	0	T	90001910	T	T	90001910	3	4	209	1	0	0	0	0	1	0	0	0	16825	1261	44	4	1065	4	TUBB3	16	90001910	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	17907301	90001910	352843	149	38193											
YWHAE	7531	broad.mit.edu	37	chr17	1268247	1268247	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgattattctccaggaggctCttctagctccaatcacattc	9	14	6	12	0	4	1	1	1	3	0	7	2	5	2	2	2	1	2	2	2	3	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr17:1268247C>A	uc002fsj.2	-	2	322	c.170G>T	c.(169-171)AGA>ATA	p.R57I	YWHAE_uc002fsk.2_Missense_Mutation_p.R35I|YWHAE_uc010vqh.1_RNA|YWHAE_uc010vqi.1_RNA	NM_006761	NP_006752	P62258	1433E_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	57		Interaction with phosphoserine on interacting protein.			apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding			lung(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)		CCAGGAGGCTCTTCTAGCTCC	0.423													5	142					3.59834e-05	4.17121e-05	1	0	A	1268247	A	A	1268247	3	1	209	1	0	0	0	0	1	0	0	0	17570	913	32	2	617	2	YWHAE	17	1268247	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08		1268247	79926963	150	38194											
MYH1	4619	broad.mit.edu	37	chr17	10395815	10395815	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggactcagcaatgtcagccCgttcctcggcctcctccagc	6	8	10	17	2	2	0	2	0	0	0	6	1	5	1	5	2	3	2	5	2	1	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr17:10395815C>T	uc002gmo.2	-	40	5832	c.5738G>A	c.(5737-5739)CGG>CAG	p.R1913Q	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1913	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						AATGTCAGCCCGTTCCTCGGC	0.483													4	165					0	0	0	0	T	10395815	T	T	10395815	3	4	209	1	0	0	0	0	1	0	0	0	10082	652	23	1	85	1	MYH1	17	10395815	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	9127568	10395815	70799395	151	38195											
GOSR1	9527	broad.mit.edu	37	chr17	28849344	28849344	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcgggactcgctcatcctagGgggtgttattgggatctgta	6	12	15	8	2	2	0	1	0	1	0	4	2	3	2	1	4	0	3	1	4	3	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr17:28849344G>A	uc002hfe.2	+	9	727	c.701G>A	c.(700-702)GGG>GAG	p.G234E	GOSR1_uc002hfd.2_Missense_Mutation_p.G232E|GOSR1_uc002hff.2_Missense_Mutation_p.G169E	NM_004871	NP_004862	O95249	GOSR1_HUMAN	golgi SNAP receptor complex member 1 isoform 1	234	Helical; Anchor for type IV membrane protein; (Potential).				intra-Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|SNARE complex	SNAP receptor activity				0						CTCATCCTAGGGGGTGTTATT	0.498													8	395					0	0	0	0	A	28849344	A	A	28849344	3	1	209	1	0	0	0	0	1	0	0	0	6614	1232	43	4	735	4	GOSR1	17	28849344	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	18453529	28849344	52345866	152	38196											
CCL23	6368	broad.mit.edu	37	chr17	34341417	34341417	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggaagctttgacatcatGaactctgtctctgcatctgg	10	13	9	9	0	4	2	1	2	3	0	5	3	4	3	0	2	3	2	0	2	3	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr17:34341417G>T	uc002hkt.1	-	2	164	c.93C>A	c.(91-93)TTC>TTA	p.F31L	CCL23_uc002hks.1_Missense_Mutation_p.F31L	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	31				MLVTALGSQARVTKDAETEFMMSKLPLENPVLL -> HAFL LPLVPGPGHKRCRDRVHECQSFHWKIQYFW (in Ref. 1).	cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	TTGACATCATGAACTCTGTCT	0.483													9	30					3.09899e-07	3.76075e-07	1	0	T	34341417	T	T	34341417	3	4	209	1	0	0	0	0	1	0	0	0	2908	1281	45	2	332	2	CCL23	17	34341417	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	5492073	34341417	46853793	153	38197											
MLLT6	4302	broad.mit.edu	37	chr17	36868952	36868952	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccctctccagagtcgaaaGgacaaagaacgccttaagca	14	6	8	13	2	1	2	0	0	1	2	4	4	2	3	3	1	2	1	3	1	4	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr17:36868952G>A	uc002hqi.3	+	8	742	c.729G>A	c.(727-729)AAG>AAA	p.K243K	MLLT6_uc010wdr.1_Silent_p.K243K|MLLT6_uc010cvm.1_Silent_p.K243K|MLLT6_uc002hqj.2_5'Flank	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	243					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					AGAGTCGAAAGGACAAAGAAC	0.592			T	MLL	AL								4	80					0	0	0	0	A	36868952	A	A	36868952	2	1	209	1	0	0	0	0	0	0	0	1	9683	991	35	4		4	MLLT6	17	36868952	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	2527535	36868952	44326258	154	38198											
KRTAP4-12	83755	broad.mit.edu	37	chr17	39280340	39280340	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccaggccacagccctggTcagagcacacagagccacaa	12	4	9	16	0	2	2	1	0	1	2	3	2	2	2	4	2	3	1	4	2	1	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr17:39280340T>C	uc002hwa.2	-	1	80	c.35A>G	c.(34-36)GAC>GGC	p.D12G		NM_031854	NP_114060	Q9BQ66	KR412_HUMAN	keratin associated protein 4-12	12	31 X 5 AA repeats of C-C-[GRQVIL]-[SPTR]- [VSTQPC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACAGCCCTGGTCAGAGCACAC	0.617													23	108					0	0	0	0	C	39280340	C	C	39280340	3	2	209	1	0	0	0	0	1	0	0	0	8590	1667	58	5	574	5	KRTAP4-12	17	39280340	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	2411388	39280340	41914870	155	38199											
HOXB5	3215	broad.mit.edu	37	chr17	46671173	46671173	+	5'Flank	DEL	G	-	-																															ctatgtatgcggccaaatatGgggggggggttggaaggggg																										TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr17:46671173delG	uc002inr.2	-							NM_002147	NP_002138	P09067	HXB5_HUMAN	homeobox B5							nucleus	sequence-specific DNA binding				0						GGCCAAATATGGGGGGGGGGT	0.473											OREG0024519	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	46671173	-	-	46671173	6	5	209	0	1	1	0	1	0	0	0	0	7343	1363	47	0		0	HOXB5	17	46671173	5'Flank	DEL	G	TCGA-CV-6954-01A-11D-1912-08	7390833	46671173	34524037	156	38200											
TCEB3C	162699	broad.mit.edu	37	chr18	44549224	44549224	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggttcaagaaccgagtaggGgaccccttccacgtcgccga	9	6	13	13	4	1	1	1	0	0	1	3	4	2	2	5	3	1	2	5	3	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr18:44549224G>A	uc010dnr.2	-	1	1075	c.1075C>T	c.(1075-1077)CCC>TCC	p.P359S	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_001100817	NP_001094287	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	359	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						ACCGAGTAGGGGACCCCTTCC	0.637													10	523					0	0	0	0	A	44549224	A	A	44549224	3	1	209	1	0	0	0	0	1	0	0	0	15749	1232	43	4	569	4	TCEB3C	18	44549224	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08		44549224	33528024	157	38201											
SERPINB11	89778	broad.mit.edu	37	chr18	61390542	61390542	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaaagcctaccaatgagagCtcagttcaaggcgaaccacc	16	5	8	12	1	2	1	2	1	0	1	2	3	2	1	4	1	4	2	4	1	6	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr18:61390542C>T	uc002ljk.3	+	9	1150	c.1088C>T	c.(1087-1089)GCT>GTT	p.A363V	SERPINB11_uc010xes.1_Missense_Mutation_p.A188V|SERPINB11_uc010dqd.2_Intron|SERPINB11_uc002ljj.3_Missense_Mutation_p.A249V|SERPINB11_uc010dqe.2_Missense_Mutation_p.A162V|SERPINB11_uc010dqf.2_Missense_Mutation_p.A161V	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	363	RCL (By similarity).				regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				CCAATGAGAGCTCAGTTCAAG	0.517													29	66					0	0	0	0	T	61390542	T	T	61390542	3	4	209	1	0	0	0	0	1	0	0	0	14163	797	28	4	1114	4	SERPINB11	18	61390542	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	16841318	61390542	16686706	158	38202											
TLE2	7089	broad.mit.edu	37	chr19	3011066	3011066	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttggcagcaagctggcagagGtgactggccgagctgggccc	7	6	17	11	1	0	2	0	1	0	1	0	3	0	2	2	5	3	5	2	5	1	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	22ae0052-7db3-4a7b-94ca-a65511e894d5	g.chr19:3011066G>A	uc002lww.2	-	12	1229	c.966C>T	c.(964-966)CAC>CAT	p.H322H	TLE2_uc010xhb.1_Missense_Mutation_p.T31I|TLE2_uc010dth.2_Silent_p.H323H|TLE2_uc010xhc.1_Silent_p.H200H|TLE2_uc010dti.2_Silent_p.H336H|TLE2_uc010xhd.1_Silent_p.H230H	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	322	Pro/Ser-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGCAGAGGTGACTGGCCG	0.657													4	16					0	0	0	0	A	3011066	A	A	3011066	2	1	209	1	0	0	0	0	0	0	0	1	16005	1252	44	4		4	TLE2	19	3011066	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08		3011066	56117917	159	38203											
EMR1	2015	broad.mit.edu	37	chr19	6926416	6926416	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgggcttcctgcactaccttTtccttgcctgcttcttctgg	2	16	8	15	1	2	0	0	0	2	0	4	0	4	0	4	2	4	3	4	2	1	7			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr19:6926416T>G	uc002mfw.2	+	16	2064	c.2026T>G	c.(2026-2028)TTC>GTC	p.F676V	EMR1_uc010dvc.2_Missense_Mutation_p.F611V|EMR1_uc010dvb.2_Missense_Mutation_p.F624V|EMR1_uc010xji.1_Missense_Mutation_p.F535V|EMR1_uc010xjj.1_Missense_Mutation_p.F499V	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	676	Helical; Name=3; (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					GCACTACCTTTTCCTTGCCTG	0.517													16	78					0	0	0	0	G	6926416	G	G	6926416	3	3	209	1	0	0	0	0	1	0	0	0	5128	1841	64	5	2088	5	EMR1	19	6926416	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	3915350	6926416	52202567	160	38204											
FCER2	2208	broad.mit.edu	37	chr19	7754314	7754314	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgggctcccctggagcccagTtgctggagcaaaaggctttg	7	9	14	11	0	0	0	0	0	0	0	1	2	1	2	3	4	3	5	3	4	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr19:7754314T>G	uc002mhn.2	-	11	915	c.731A>C	c.(730-732)AAC>ACC	p.N244T	FCER2_uc010xjs.1_Missense_Mutation_p.N166T|FCER2_uc010xjt.1_Missense_Mutation_p.N166T|FCER2_uc002mhm.2_Missense_Mutation_p.N244T	NM_002002	NP_001993	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor	244	C-type lectin.|Extracellular (Potential).				positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding				0						TGGAGCCCAGTTGCTGGAGCA	0.667													2	7					0	0	0	0	G	7754314	G	G	7754314	3	3	209	1	0	0	0	0	1	0	0	0	5808	1725	60	5	238	5	FCER2	19	7754314	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	827898	7754314	51374669	161	38205											
CLEC4G	339390	broad.mit.edu	37	chr19	7794310	7794310	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcgctgtcacacggtgcgTcgttccacagccccgtgtgc	4	10	11	16	5	2	0	1	0	1	0	5	0	3	0	3	1	3	2	3	1	0	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr19:7794310T>C	uc002mhp.3	-	9	893	c.824A>G	c.(823-825)GAC>GGC	p.D275G		NM_198492	NP_940894	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	275	Extracellular (Potential).|C-type lectin.					integral to membrane	protein binding|sugar binding				0						ACACGGTGCGTCGTTCCACAG	0.632													3	47					0	0	0	0	C	7794310	C	C	7794310	3	2	209	1	0	0	0	0	1	0	0	0	3532	1667	58	5	61	5	CLEC4G	19	7794310	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	39996	7794310	51334673	162	38206											
ARRDC2	27106	broad.mit.edu	37	chr19	18119198	18119198	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgagcccgtgtttagcggcGgccaggccgtggcgggccgg	3	6	19	13	7	0	0	0	0	0	0	1	1	0	0	4	6	2	1	4	6	1	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr19:18119198G>A	uc002nhv.2	+	1	222	c.79G>A	c.(79-81)GGC>AGC	p.G27S	ARRDC2_uc002nhu.2_Intron	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2 isoform 1	27										pancreas(1)	1						GTTTAGCGGCGGCCAGGCCGT	0.726													8	26					0	0	0	0	A	18119198	A	A	18119198	3	1	209	1	0	0	0	0	1	0	0	0	985	1116	39	1	344	1	ARRDC2	19	18119198	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	10324888	18119198	41009785	163	38207											
NUDT19	390916	broad.mit.edu	37	chr19	33200163	33200163	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccacccccacagttctacGaagtgagaagacttgcaaac	13	7	8	13	1	1	2	0	1	1	2	1	4	1	2	3	0	4	2	3	0	4	3	rs149924778	by1000genomes	TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr19:33200163G>A	uc010edf.2	+	2	787	c.787G>A	c.(787-789)GAA>AAA	p.E263K		NM_001105570	NP_001099040	A8MXV4	NUD19_HUMAN	nudix (nucleoside diphosphate linked moiety	263	Nudix hydrolase.					mitochondrion|peroxisome	hydrolase activity|metal ion binding				0	Esophageal squamous(110;0.137)					ACAGTTCTACGAAGTGAGAAG	0.443													11	234					0	0	0	0	A	33200163	A	A	33200163	3	1	209	1	0	0	0	0	1	0	0	0	10790	1059	37	1	793	1	NUDT19	19	33200163	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	15080965	33200163	25928820	164	38208											
DYRK1B	9149	broad.mit.edu	37	chr19	40321138	40321140	+	In_Frame_Del	DEL	CTT	-	-																															tggttcaggaccttcttctcCttcttgttgctcgaatcctg																										TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr19:40321138_40321140delCTT	uc002omj.2	-	4	527_529	c.247_249delAAG	c.(247-249)AAGdel	p.K83del	DYRK1B_uc002omi.2_In_Frame_Del_p.K83del|DYRK1B_uc002omk.2_In_Frame_Del_p.K83del|DYRK1B_uc002oml.2_In_Frame_Del_p.K83del	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	83	Bipartite nuclear localization signal (Potential).				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CCTTCTTCTCCTTCTTGTTGCTC	0.581													---	---	---								-	40321140	-	-	40321138	7	5	209	1	0	1	0	1	0	0	0	0	4877	680	24	0	1672	0	DYRK1B	19	40321138	In_Frame_Del	DEL	CTT	TCGA-CV-6954-01A-11D-1912-08	7120975	40321138	18807845	165	38209											
ATP1A3	478	broad.mit.edu	37	chr19	42471441	42471441	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgagtttgcggatttcgtcGtagacgaagatgaggaaact	12	11	13	5	4	0	4	0	2	0	2	2	7	0	6	0	2	2	2	0	2	3	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr19:42471441G>A	uc002osg.2	-	22	3127	c.2973C>T	c.(2971-2973)TAC>TAT	p.Y991Y	ATP1A3_uc010xwf.1_Silent_p.Y1002Y|ATP1A3_uc010xwg.1_Silent_p.Y961Y|ATP1A3_uc010xwh.1_Silent_p.Y1004Y|ATP1A3_uc002osh.2_Silent_p.Y991Y	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	991	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						GGATTTCGTCGTAGACGAAGA	0.652													22	29					0	0	0	0	A	42471441	A	A	42471441	2	1	209	1	0	0	0	0	0	0	0	1	1132	1140	40	1		1	ATP1A3	19	42471441	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	2150303	42471441	16657542	166	38210											
CACNG8	59283	broad.mit.edu	37	chr19	54466493	54466493	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggcgccttcgccgccttcGgcctcatgaccatcgccatc	4	9	10	18	5	1	1	1	1	0	0	5	1	1	1	6	2	0	0	6	2	0	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr19:54466493G>A	uc002qcs.1	+	1	200	c.94G>A	c.(94-96)GGC>AGC	p.G32S		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	33	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		CGCCGCCTTCGGCCTCATGAC	0.667													9	23					0	0	0	0	A	54466493	A	A	54466493	3	1	209	1	0	0	0	0	1	0	0	0	2575	1116	39	1	99	1	CACNG8	19	54466493	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	11995052	54466493	4662490	167	38211											
ZNF446	55663	broad.mit.edu	37	chr19	58991738	58991738	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccccaggaagccctacaCgtgcgagcagtgtggccgcg	8	4	13	16	4	0	0	0	0	0	0	0	2	0	1	4	2	4	1	4	2	2	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr19:58991738C>T	uc002qsz.2	+	7	1115	c.998C>T	c.(997-999)ACG>ATG	p.T333M	ZNF446_uc002qta.2_Missense_Mutation_p.R305C|ZNF446_uc010eur.2_3'UTR|SLC27A5_uc002qtb.2_RNA	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	333	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AAGCCCTACACGTGCGAGCAG	0.682													7	22					0	0	0	0	T	58991738	T	T	58991738	3	4	209	1	0	0	0	0	1	0	0	0	17986	536	19	1	1020	1	ZNF446	19	58991738	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	4525245	58991738	137245	168	38212											
NOP56	10528	broad.mit.edu	37	chr20	2636321	2636321	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttatctgaataccgccagAgcctacacacttacctgcgc	10	10	6	15	2	1	2	0	1	1	1	1	2	1	2	4	0	5	0	4	0	5	5			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:2636321A>G	uc002wgh.2	+	7	891	c.838A>G	c.(838-840)AGC>GGC	p.S280G	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_Missense_Mutation_p.S114G|NOP56_uc002wgm.1_Missense_Mutation_p.S27G|SNORD86_uc010gaq.1_5'Flank|SNORD56_uc010gar.2_5'Flank|SNORD57_uc002wgo.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	280	Nop.				rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						ATACCGCCAGAGCCTACACAC	0.512													19	160					0	0	0	0	G	2636321	G	G	2636321	3	3	209	1	0	0	0	0	1	0	0	0	10593	304	11	5	864	5	NOP56	20	2636321	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08		2636321	60389199	169	38213											
CENPB	1059	broad.mit.edu	37	chr20	3766487	3766487	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcttgacgcggccgtccgTcgcctccgcacagccccgcg	3	6	13	19	8	0	1	0	1	0	0	3	1	2	1	6	2	1	2	6	2	0	1			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:3766487T>C	uc002wjk.2	-	1	851	c.644A>G	c.(643-645)GAC>GGC	p.D215G	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	215					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						CGGCCGTCCGTCGCCTCCGCA	0.711													14	144					0	0	0	0	C	3766487	C	C	3766487	3	2	209	1	0	0	0	0	1	0	0	0	3242	1667	58	5	1159	5	CENPB	20	3766487	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	1130166	3766487	59259033	170	38214			1	56		2	2	15	N	T_C	8.501842e-05
CENPB	1059	broad.mit.edu	37	chr20	3766501	3766501	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgtccgtcgcctccgcacagCcccgcggcctggtcgggcag	3	5	14	19	7	0	0	0	0	0	0	4	0	2	0	6	3	1	2	6	3	0	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:3766501C>A	uc002wjk.2	-	1	837	c.630G>T	c.(628-630)GGG>GGT	p.G210G	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	210					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						CTCCGCACAGCCCCGCGGCCT	0.711													19	143					2.4624e-09	3.03565e-09	1	0	A	3766501	A	A	3766501	2	1	209	1	0	0	0	0	0	0	0	1	3242	726	26	4		4	CENPB	20	3766501	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	14	3766501	59259019	171	38215			1	56		2	2	15	N	T_C	8.501842e-05
SNTA1	6640	broad.mit.edu	37	chr20	32026759	32026759	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atggcatcccccacaaaaagGgcctctgtctggtcagctgc	9	8	10	14	0	3	0	1	0	2	0	4	0	4	0	3	3	2	2	3	3	2	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:32026759G>A	uc002wzd.1	-	2	656	c.384C>T	c.(382-384)GCC>GCT	p.A128A	SNTA1_uc010zuf.1_Silent_p.A128A	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	128	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						CCACAAAAAGGGCCTCTGTCT	0.542													5	305					0	0	0	0	A	32026759	A	A	32026759	2	1	209	1	0	0	0	0	0	0	0	1	14935	1219	43	4		4	SNTA1	20	32026759	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	28260258	32026759	30998761	172	38216											
PTPRT	11122	broad.mit.edu	37	chr20	40710644	40710644	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcacagaaggttccactacGgcctcccccatttctaaaca	11	8	7	15	1	1	1	0	0	1	1	3	1	3	1	4	3	2	2	4	3	4	4	rs144244064		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:40710644G>T	uc002xkg.2	-	30	4334	c.4150C>A	c.(4150-4152)CGT>AGT	p.R1384S	PTPRT_uc010ggj.2_Missense_Mutation_p.R1403S|PTPRT_uc010ggi.2_Missense_Mutation_p.R587S	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1384	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.R1406C(1)		skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GTTCCACTACGGCCTCCCCCA	0.483													5	171					5.9392e-07	7.13316e-07	1	0	T	40710644	T	T	40710644	3	4	209	1	0	0	0	0	1	0	0	0	12877	1116	39	3	183	3	PTPRT	20	40710644	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	8683885	40710644	22314876	173	38217											
SGK2	10110	broad.mit.edu	37	chr20	42195754	42195754	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggggccttcagccaaccCaaagtgagttctggtccctc	7	9	10	15	0	2	1	1	1	1	0	4	1	3	1	5	3	2	1	5	3	2	2	rs141029147		TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:42195754C>T	uc002xkv.2	+	2	482	c.263C>T	c.(262-264)CCA>CTA	p.P88L	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.P28L|SGK2_uc010ggm.2_Missense_Mutation_p.P28L|SGK2_uc002xks.2_Missense_Mutation_p.P28L|SGK2_uc002xku.2_Missense_Mutation_p.P28L|SGK2_uc002xkq.1_Missense_Mutation_p.P28L	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	88					intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TCAGCCAACCCAAAGTGAGTT	0.512													4	76					0	0	0	0	T	42195754	T	T	42195754	3	4	209	1	0	0	0	0	1	0	0	0	14274	594	21	4	269	4	SGK2	20	42195754	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	1485110	42195754	20829766	174	38218											
WFDC3	140686	broad.mit.edu	37	chr20	44416545	44416545	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcagcatttctttacaccTggacatgtctcatcagtgat	9	14	8	10	0	3	1	2	1	2	0	4	2	3	2	1	1	3	2	1	1	1	3			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:44416545T>C	uc002xpf.1	-	4	372	c.288A>G	c.(286-288)CCA>CCG	p.P96P	WFDC3_uc002xpj.1_RNA|WFDC3_uc002xph.1_RNA|WFDC3_uc010ghh.1_RNA	NM_080614	NP_542181	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3 precursor	96	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				TCTTTACACCTGGACATGTCT	0.473													14	133					0	0	0	0	C	44416545	C	C	44416545	2	2	209	1	0	0	0	0	0	0	0	1	17421	1567	55	5		5	WFDC3	20	44416545	Silent	SNP	T	TCGA-CV-6954-01A-11D-1912-08	2220791	44416545	18608975	175	38219											
SLC9A8	23315	broad.mit.edu	37	chr20	48500552	48500552	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggacatcgaggacgccaaGgcacaccgcaggaacaagaa	16	2	12	11	3	0	1	0	0	0	1	1	5	0	4	2	4	1	2	2	4	4	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:48500552G>T	uc002xuv.1	+	14	1650	c.1440G>T	c.(1438-1440)AAG>AAT	p.K480N	SLC9A8_uc010zym.1_Missense_Mutation_p.K180N|SLC9A8_uc010gic.2_Missense_Mutation_p.K180N|SLC9A8_uc010gid.2_Missense_Mutation_p.K104N	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	480						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			AGGACGCCAAGGCACACCGCA	0.612													5	175					5.9392e-07	7.13316e-07	1	0	T	48500552	T	T	48500552	3	4	209	1	0	0	0	0	1	0	0	0	14784	991	35	4	1494	4	SLC9A8	20	48500552	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	4084007	48500552	14524968	176	38220											
NFATC2	4773	broad.mit.edu	37	chr20	50140072	50140072	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggccggacggggcacgggCgagtggcggcccaggcagct	6	2	21	12	5	0	0	0	0	0	0	0	3	0	1	2	8	1	3	2	8	0	0			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:50140072C>T	uc002xwd.2	-	2	928	c.708G>A	c.(706-708)TCG>TCA	p.S236S	NFATC2_uc002xwc.2_Silent_p.S236S|NFATC2_uc010zyv.1_Silent_p.S17S|NFATC2_uc010zyw.1_Silent_p.S17S|NFATC2_uc010zyx.1_Silent_p.S216S|NFATC2_uc010zyy.1_Silent_p.S17S|NFATC2_uc010zyz.1_Silent_p.S17S|NFATC2_uc002xwe.2_Silent_p.S216S	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	236	3 X approximate SP repeats.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GGGGCACGGGCGAGTGGCGGC	0.667													22	200					0	0	0	0	T	50140072	T	T	50140072	2	4	209	1	0	0	0	0	0	0	0	1	10416	755	27	1		1	NFATC2	20	50140072	Silent	SNP	C	TCGA-CV-6954-01A-11D-1912-08	1639520	50140072	12885448	177	38221											
ZFP64	55734	broad.mit.edu	37	chr20	50705115	50705115	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactggtgtggcaccgcatGtgcatggtcaggttgtcctt	6	12	13	10	1	1	0	1	0	0	0	2	0	2	0	2	4	1	4	2	4	0	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:50705115G>A	uc002xwk.2	-	8	1393	c.1044C>T	c.(1042-1044)CAC>CAT	p.H348H	ZFP64_uc002xwj.2_Silent_p.H129H	NM_199427	NP_955459	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform d	305	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GGCACCGCATGTGCATGGTCA	0.522													83	121					0	0	0	0	A	50705115	A	A	50705115	2	1	209	1	0	0	0	0	0	0	0	1	17719	1368	48	4		4	ZFP64	20	50705115	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	565043	50705115	12320405	178	38222											
TCFL5	10732	broad.mit.edu	37	chr20	61490757	61490757	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcaggcaaaactttgtttCtactacctaacgtctgttta	10	15	6	10	1	3	0	1	0	2	0	3	0	3	0	1	1	4	4	1	1	6	7			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr20:61490757C>G	uc002ydp.2	-	3	1046	c.953G>C	c.(952-954)AGA>ACA	p.R318T	TCFL5_uc002ydo.2_Missense_Mutation_p.R91T|TCFL5_uc002ydq.2_Missense_Mutation_p.R318T	NM_006602	NP_006593	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 protein	318					cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)	1	Breast(26;5.68e-08)					AACTTTGTTTCTACTACCTAA	0.443													35	329					0	0	0	0	G	61490757	G	G	61490757	3	3	209	1	0	0	0	0	1	0	0	0	15765	913	32	2	565	2	TCFL5	20	61490757	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08	10785642	61490757	1534763	179	38223											
SYNJ1	8867	broad.mit.edu	37	chr21	34025655	34025655	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttccctccaaaaatgtaacCcacattttatcttctacaaa	14	13	1	13	0	2	0	0	0	2	0	4	0	4	0	3	0	2	1	3	0	6	6			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr21:34025655C>A	uc002yqh.2	-	22	2934	c.2934G>T	c.(2932-2934)TGG>TGT	p.W978C	SYNJ1_uc011ads.1_Missense_Mutation_p.W934C|SYNJ1_uc002yqf.2_Missense_Mutation_p.W939C|SYNJ1_uc002yqg.2_Missense_Mutation_p.W934C|SYNJ1_uc002yqi.2_Missense_Mutation_p.W978C	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	939	RRM.|Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						AAAATGTAACCCACATTTTAT	0.323													4	37					0.00909568	0.00985718	1	0	A	34025655	A	A	34025655	3	1	209	1	0	0	0	0	1	0	0	0	15518	624	22	4	1973	4	SYNJ1	21	34025655	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08		34025655	14104240	180	38224											
SYNJ1	8867	broad.mit.edu	37	chr21	34072212	34072212	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgcattaagactcaaatctaAactgatgccagatgcagacc	15	8	7	11	1	2	4	1	1	1	3	2	4	2	4	2	0	3	2	2	0	4	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr21:34072212A>T	uc002yqh.2	-	4	532	c.532T>A	c.(532-534)TTA>ATA	p.L178I	SYNJ1_uc011ads.1_Missense_Mutation_p.L139I|SYNJ1_uc002yqf.2_Missense_Mutation_p.L139I|SYNJ1_uc002yqg.2_Missense_Mutation_p.L139I|SYNJ1_uc002yqi.2_Missense_Mutation_p.L178I	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	139	SAC.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						CTCAAATCTAAACTGATGCCA	0.388													6	24					0	0	0	0	T	34072212	T	T	34072212	3	4	209	1	0	0	0	0	1	0	0	0	15518	11	1	5	4456	5	SYNJ1	21	34072212	Missense_Mutation	SNP	A	TCGA-CV-6954-01A-11D-1912-08	46557	34072212	14057683	181	38225											
CRYZL1	9946	broad.mit.edu	37	chr21	34997056	34997056	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaagttatcctctgtaacaGgaagatcttcctagaaccaa	15	10	6	10	0	2	2	0	0	2	2	4	3	4	3	3	1	2	2	3	1	7	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr21:34997056G>T	uc011adw.1	-	3	257	c.77C>A	c.(76-78)CCT>CAT	p.P26H	DONSON_uc002ysn.1_Intron|CRYZL1_uc002ysr.1_Missense_Mutation_p.P50H|CRYZL1_uc002yss.1_RNA|CRYZL1_uc002yst.1_RNA|CRYZL1_uc002ysu.2_Missense_Mutation_p.P26H	NM_145858	NP_665857	O95825	QORL1_HUMAN	crystallin, zeta-like 1	26					quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding				0						CTCTGTAACAGGAAGATCTTC	0.299													14	57					1.3612e-06	1.62646e-06	1	0	T	34997056	T	T	34997056	3	4	209	1	0	0	0	0	1	0	0	0	3938	1000	35	4	1016	4	CRYZL1	21	34997056	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08	924844	34997056	13132839	182	38226											
RTN4R	65078	broad.mit.edu	37	chr22	20229737	20229737	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtggccacagcgcagccctGcaggtcattggcagctaggc	7	6	15	13	1	1	0	1	0	0	0	1	0	1	0	2	5	4	4	2	5	1	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr22:20229737G>A	uc002zrv.2	-	2	1120	c.919C>T	c.(919-921)CAG>TAG	p.Q307*	RTN4R_uc002zru.2_Nonsense_Mutation_p.Q79*	NM_023004	NP_075380	Q9BZR6	RTN4R_HUMAN	reticulon 4 receptor precursor	307	LRRCT.				axonogenesis|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|cell surface|endoplasmic reticulum|plasma membrane	protein binding|receptor activity				0	Colorectal(54;0.0993)					GCGCAGCCCTGCAGGTCATTG	0.682													7	12					0	0	0	0	A	20229737	A	A	20229737	4	1	209	1	0	0	0	0	0	1	0	0	13795	1328	46	4	506	4	RTN4R	22	20229737	Nonsense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08		20229737	31074829	183	38227											
XBP1	7494	broad.mit.edu	37	chr22	29196498	29196499	+	In_Frame_Ins	INS	-	GCC	GCC																															cggccgggttcggcgcggctINSgccaccaccaccatagctcc																										TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chr22:29196498_29196499insGCC	uc011akl.1	-	1	62_63	c.14_15insGGC	c.(13-15)GCA>GCGGCA	p.5_5A>AA	XBP1_uc003aed.2_5'Flank|XBP1_uc003aef.2_5'UTR	NM_001079539	NP_001073007	P17861	XBP1_HUMAN	X-box binding protein 1 isoform XBP1(S)	5					immune response	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						TCGGCGCGGCTGCCACCACCAC	0.762													---	---	---								GCC	29196499	GCC	GCC	29196498	7	5	209	1	0	1	1	0	0	0	0	0	17490	1567	55	0	1161	0	XBP1	22	29196498	In_Frame_Ins	INS	-	TCGA-CV-6954-01A-11D-1912-08	8966761	29196498	22108068	184	38228											
ZMAT1	84460	broad.mit.edu	37	chrX	101139015	101139015	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaggtaactggttttccaCtacttgtgaaatactatatg	12	15	8	6	0	0	2	0	2	0	0	1	2	1	2	1	2	3	2	1	2	6	8			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chrX:101139015C>T	uc004eim.2	-	2	4369	c.871G>A	c.(871-873)GTG>ATG	p.V291M	ZMAT1_uc011mrl.1_Missense_Mutation_p.V462M|ZMAT1_uc004ein.2_Missense_Mutation_p.V291M|ZMAT1_uc011mrm.1_Missense_Mutation_p.V291M	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	291						nucleus	zinc ion binding			ovary(1)	1						TGGTTTTCCACTACTTGTGAA	0.413													31	34					0	0	0	0	T	101139015	T	T	101139015	3	4	209	1	0	0	0	0	1	0	0	0	17758	565	20	4	536	4	ZMAT1	23	101139015	Missense_Mutation	SNP	C	TCGA-CV-6954-01A-11D-1912-08		101139015	54131545	185	38229											
ACSL4	2182	broad.mit.edu	37	chrX	108902623	108902623	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttctttcagtatttcagcTtccatagcaggattattgca	10	17	6	8	0	3	0	2	0	1	0	4	1	4	1	1	1	3	4	1	1	3	8			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chrX:108902623T>A	uc004eoi.2	-	16	2443	c.1938A>T	c.(1936-1938)GAA>GAT	p.E646D	ACSL4_uc004eoj.2_Missense_Mutation_p.E605D|ACSL4_uc004eok.2_Missense_Mutation_p.E605D	NM_022977	NP_075266	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	646	Cytoplasmic (Potential).				fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(1)|lung(1)|ovary(1)	3					Icosapent(DB00159)|Troglitazone(DB00197)	GTATTTCAGCTTCCATAGCAG	0.393													31	26					0	0	0	0	A	108902623	A	A	108902623	3	1	209	1	0	0	0	0	1	0	0	0	179	1606	56	5	205	5	ACSL4	23	108902623	Missense_Mutation	SNP	T	TCGA-CV-6954-01A-11D-1912-08	7763608	108902623	46367937	186	38230											
SMARCA1	6594	broad.mit.edu	37	chrX	128640093	128640093	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatcaggcaataaaaagttGagtaaggcccacagttcatg	16	8	9	8	0	2	1	2	1	0	0	2	1	2	1	1	2	0	4	1	2	5	4			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chrX:128640093G>A	uc004eun.3	-	8	1175	c.1062C>T	c.(1060-1062)CTC>CTT	p.L354L	SMARCA1_uc004eup.3_Silent_p.L354L|SMARCA1_uc011muk.1_Silent_p.L354L|SMARCA1_uc011mul.1_Silent_p.L354L	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	354	Helicase ATP-binding.				ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						ATAAAAAGTTGAGTAAGGCCC	0.373													35	33					0	0	0	0	A	128640093	A	A	128640093	2	1	209	1	0	0	0	0	0	0	0	1	14832	1277	45	2		2	SMARCA1	23	128640093	Silent	SNP	G	TCGA-CV-6954-01A-11D-1912-08	19737470	128640093	26630467	187	38231											
NLGN4Y	22829	broad.mit.edu	37	chrY	16936196	16936196	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaagagagtgactatctttGgctcgggggctggggcctcc	6	9	15	11	1	1	2	0	1	1	1	3	3	2	2	3	5	0	2	3	5	2	2			TCGA-CV-6954-01A-11D-1912-08	TCGA-CV-6954-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	08f56645-763e-4864-a145-c0136dacd4f5	225e74d6-d99d-46a6-8a4d-2a13df472d3b	g.chrY:16936196G>T	uc004ftg.2	+	4	1006	c.754G>T	c.(754-756)GGC>TGC	p.G252C	NLGN4Y_uc004fte.2_Missense_Mutation_p.G84C|NLGN4Y_uc011nas.1_Missense_Mutation_p.G272C|NLGN4Y_uc004ftf.2_5'UTR|NLGN4Y_uc004fth.2_Missense_Mutation_p.G252C	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	252	Extracellular (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						GACTATCTTTGGCTCGGGGGC	0.567													5	56					3.59834e-05	4.17121e-05	1	0	T	16936196	T	T	16936196	3	4	209	1	0	0	0	0	1	0	0	0	10519	1348	47	4	918	4	NLGN4Y	24	16936196	Missense_Mutation	SNP	G	TCGA-CV-6954-01A-11D-1912-08		16936196	42437370	188	38232											
PLEKHG5	57449	broad.mit.edu	37	chr1	6534542	6534542	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtagtgtcccccgaacctGtaggcctcgaaggtgaggga	9	7	15	10	2	0	1	0	1	0	0	2	4	1	2	4	4	1	2	4	4	4	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:6534542G>A	uc001ano.1	-	7	677	c.576C>T	c.(574-576)TAC>TAT	p.Y192Y	PLEKHG5_uc001ann.1_Silent_p.Y173Y|PLEKHG5_uc001anq.1_Silent_p.Y213Y|PLEKHG5_uc001anp.1_Silent_p.Y213Y|PLEKHG5_uc001anj.1_5'Flank|PLEKHG5_uc009vma.1_5'UTR|PLEKHG5_uc010nzr.1_Silent_p.Y205Y|PLEKHG5_uc001ank.1_Silent_p.Y136Y|PLEKHG5_uc009vmb.1_Silent_p.Y136Y|PLEKHG5_uc001anl.1_Silent_p.Y136Y|PLEKHG5_uc001anm.1_Silent_p.Y136Y	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	192					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CCCCGAACCTGTAGGCCTCGA	0.607													6	29					0	0	0	0	A	6534542	A	A	6534542	2	1	210	1	0	0	0	0	0	0	0	1	12128	1372	48	4		4	PLEKHG5	1	6534542	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08		6534542	242716079	1	38233											
NOL9	79707	broad.mit.edu	37	chr1	6609717	6609717	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttctagcaacacaatggAacactgaggagaaaaattct	17	9	8	7	0	2	2	0	1	2	1	2	4	2	3	0	2	3	2	0	2	6	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:6609717A>G	uc001ans.2	-	3	677	c.658T>C	c.(658-660)TCC>CCC	p.S220P	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	220					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		AACACAATGGAACACTGAGGA	0.413													7	71					0	0	0	0	G	6609717	G	G	6609717	3	3	210	1	0	0	0	0	1	0	0	0	10582	246	9	5	1490	5	NOL9	1	6609717	Missense_Mutation	SNP	A	TCGA-CV-6955-01A-11D-2012-08	75175	6609717	242640904	2	38234											
VPS13D	55187	broad.mit.edu	37	chr1	12569009	12569009	+	Frame_Shift_Del	DEL	C	-	-																															gaaataaactacgcaaagagCctctactatgaacagcagct																										TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:12569009delC	uc001atv.2	+	70	13239	c.13098delC	c.(13096-13098)AGCfs	p.S4366fs	VPS13D_uc001atw.2_Frame_Shift_Del_p.S4341fs|VPS13D_uc001atx.2_Frame_Shift_Del_p.S3553fs|VPS13D_uc009vnl.2_RNA|VPS13D_uc010obd.1_Frame_Shift_Del_p.S364fs	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	4365					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACGCAAAGAGCCTCTACTATG	0.522													---	---	---								-	12569009	-	-	12569009	7	5	210	1	0	1	0	1	0	0	0	0	17260	738	26	0	13372	0	VPS13D	1	12569009	Frame_Shift_Del	DEL	C	TCGA-CV-6955-01A-11D-2012-08	5959292	12569009	236681612	3	38235											
CELA2A	63036	broad.mit.edu	37	chr1	15789236	15789236	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctttctcccagctcctccaGgacctaccgcgtggggctgg	4	9	11	17	2	1	0	0	0	1	0	4	1	3	1	6	4	2	2	6	4	1	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:15789236G>C	uc001awk.2	+	4	262	c.236G>C	c.(235-237)AGG>ACG	p.R79T		NM_033440	NP_254275	P08217	CEL2A_HUMAN	elastase 2A preproprotein	79	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						AGCTCCTCCAGGACCTACCGC	0.617													29	59					0	0	0	0	C	15789236	C	C	15789236	3	2	210	1	0	0	0	0	1	0	0	0	3226	1000	35	4	250	4	CELA2A	1	15789236	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	3220227	15789236	233461385	4	38236											
HSPG2	3339	broad.mit.edu	37	chr1	22172685	22172685	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagagctgcccatcacccGgcacacgtattcacccgagt	9	6	9	17	3	2	1	2	0	0	1	2	2	2	1	4	1	2	3	4	1	1	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:22172685G>A	uc001bfj.2	-	64	8420	c.8380C>T	c.(8380-8382)CGG>TGG	p.R2794W	HSPG2_uc009vqd.2_Missense_Mutation_p.R2795W	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2794	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCCATCACCCGGCACACGTAT	0.657													15	29					0	0	0	0	A	22172685	A	A	22172685	3	1	210	1	0	0	0	0	1	0	0	0	7469	1115	39	1	4931	1	HSPG2	1	22172685	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	6383449	22172685	227077936	5	38237											
DMRTB1	63948	broad.mit.edu	37	chr1	53930414	53930414	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcagccccagttcctcccGccaggctacctctctgcgct	4	8	8	21	3	1	0	0	0	1	0	4	0	3	0	7	1	3	4	7	1	1	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:53930414G>A	uc001cvq.1	+	3	910	c.855G>A	c.(853-855)CCG>CCA	p.P285P		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	285	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						AGTTCCTCCCGCCAGGCTACC	0.522													13	73					0	0	0	0	A	53930414	A	A	53930414	2	1	210	1	0	0	0	0	0	0	0	1	4612	1074	38	1		1	DMRTB1	1	53930414	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	31757729	53930414	195320207	6	38238											
C1orf168	199920	broad.mit.edu	37	chr1	57257877	57257877	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagacgttatgtaatattttGggggccaccacgtgcttctg	8	13	12	8	2	1	1	0	0	1	1	1	2	1	1	2	2	1	3	2	2	3	6			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:57257877G>T	uc001cym.3	-	2	1015	c.609C>A	c.(607-609)CCC>CCA	p.P203P	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Silent_p.P203P	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	203										ovary(3)|skin(2)	5						GTAATATTTTGGGGGCCACCA	0.488													9	123					2.17888e-05	2.39805e-05	1	0	T	57257877	T	T	57257877	2	4	210	1	0	0	0	0	0	0	0	1	2021	1335	47	4		4	C1orf168	1	57257877	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	3327463	57257877	191992744	7	38239											
PTGFR	5737	broad.mit.edu	37	chr1	79002110	79002110	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggttacaatggccaacattgGaataaatggaaatcattctc	15	11	8	7	0	2	0	1	0	1	0	3	2	2	2	1	4	2	1	1	4	7	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:79002110G>A	uc001din.2	+	3	1084	c.818G>A	c.(817-819)GGA>GAA	p.G273E	PTGFR_uc001dim.2_Missense_Mutation_p.E297K	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	273	Extracellular (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GCCAACATTGGAATAAATGGA	0.343													4	56					0	0	0	0	A	79002110	A	A	79002110	3	1	210	1	0	0	0	0	1	0	0	0	12812	1175	41	2	899	2	PTGFR	1	79002110	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	21744233	79002110	170248511	8	38240											
KCNA3	3738	broad.mit.edu	37	chr1	111216780	111216780	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagagcagccacacctggcGctggaagtcgcggcggggca	9	3	17	12	4	0	1	0	0	0	1	1	3	0	2	2	5	2	3	2	5	2	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:111216780G>A	uc001dzv.1	-	1	876	c.652C>T	c.(652-654)CGC>TGC	p.R218C		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	218						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACACCTGGCGCTGGAAGTCG	0.672													9	58					0	0	0	0	A	111216780	A	A	111216780	3	1	210	1	0	0	0	0	1	0	0	0	8043	1087	38	1	1079	1	KCNA3	1	111216780	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	32214670	111216780	138033841	9	38241											
UBQLN4	56893	broad.mit.edu	37	chr1	156020169	156020169	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctgggggttggccataatCatgtgacgcatcagatcagg	10	10	13	8	1	4	2	3	1	1	1	4	2	4	2	1	4	0	2	1	4	1	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:156020169C>T	uc001fna.2	-	4	678	c.654G>A	c.(652-654)ATG>ATA	p.M218I	UBQLN4_uc010pgx.1_Missense_Mutation_p.M198I	NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	218						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)|skin(1)	2	Hepatocellular(266;0.133)|all_neural(408;0.195)					TGGCCATAATCATGTGACGCA	0.522													6	137					0	0	0	0	T	156020169	T	T	156020169	3	4	210	1	0	0	0	0	1	0	0	0	16967	826	29	2	1183	2	UBQLN4	1	156020169	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	44803389	156020169	93230452	10	38242											
DDX59	83479	broad.mit.edu	37	chr1	200619738	200619738	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccaaaatggtctgacaatCattaggaatgttttccaaaa	17	11	6	7	0	2	1	1	1	1	0	3	2	3	2	2	2	1	1	2	2	8	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:200619738C>G	uc009wzk.2	-	5	1372	c.1129G>C	c.(1129-1131)GAT>CAT	p.D377H	DDX59_uc010ppl.1_Missense_Mutation_p.D377H	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	377	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GTCTGACAATCATTAGGAATG	0.353													3	39					0	0	0	0	G	200619738	G	G	200619738	3	3	210	1	0	0	0	0	1	0	0	0	4393	826	29	2	746	2	DDX59	1	200619738	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	44599569	200619738	48630883	11	38243											
C1orf69	200205	broad.mit.edu	37	chr1	228362900	228362900	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctggccttcatgaacggcGtgagcttcaccaaaggctgc	9	8	11	13	2	2	2	2	2	0	0	2	2	2	2	3	3	3	2	3	3	2	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:228362900G>A	uc001hsl.3	+	3	846	c.757G>A	c.(757-759)GTG>ATG	p.V253M	C1orf69_uc010pvw.1_Missense_Mutation_p.V60M	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	253					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				CATGAACGGCGTGAGCTTCAC	0.642													10	92					0	0	0	0	A	228362900	A	A	228362900	3	1	210	1	0	0	0	0	1	0	0	0	2067	1145	40	1	767	1	C1orf69	1	228362900	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	27743162	228362900	20887721	12	38244											
C1orf198	84886	broad.mit.edu	37	chr1	230979431	230979431	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggcctcaggcccctcccctCgggaccgctcagcattgatc	5	7	10	19	3	2	1	2	1	0	0	5	2	3	2	6	3	1	2	6	3	0	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:230979431C>T	uc001hub.2	-	3	640	c.596G>A	c.(595-597)CGA>CAA	p.R199Q	C1orf198_uc009xfh.1_Missense_Mutation_p.R69Q|C1orf198_uc001huc.1_5'UTR|C1orf198_uc001hud.1_Missense_Mutation_p.R161Q	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	199											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				CCCCTCCCCTCGGGACCGCTC	0.627													24	111					0	0	0	0	T	230979431	T	T	230979431	3	4	210	1	0	0	0	0	1	0	0	0	2035	884	31	1	395	1	C1orf198	1	230979431	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	2616531	230979431	18271190	13	38245											
OR2L3	391192	broad.mit.edu	37	chr1	248224880	248224880	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aacaaggaggtgatgggggcCctgacacgagtgagtcagag	12	5	17	7	1	1	4	1	3	0	1	1	6	1	5	1	4	1	0	1	4	2	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:248224880C>A	uc001idx.1	+	1	897	c.897C>A	c.(895-897)GCC>GCA	p.A299A	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGATGGGGGCCCTGACACGAG	0.493													10	58					0.00621372	0.00660429	1	0	A	248224880	A	A	248224880	2	1	210	1	0	0	0	0	0	0	0	1	11062	610	22	4		4	OR2L3	1	248224880	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	17245449	248224880	1025741	14	38246											
OR2M3	127062	broad.mit.edu	37	chr1	248366774	248366774	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctaagatacaccaatctCatgagccctaaaatttgtgg	13	11	6	11	0	2	2	1	1	2	1	3	2	2	2	3	1	2	0	3	1	5	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr1:248366774C>G	uc010pzg.1	+	1	405	c.405C>G	c.(403-405)CTC>CTG	p.L135L		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACACCAATCTCATGAGCCCTA	0.438													13	247					0	0	0	0	G	248366774	G	G	248366774	2	3	210	1	0	0	0	0	0	0	0	1	11065	813	29	2		2	OR2M3	1	248366774	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	141894	248366774	883847	15	38247											
GALNT14	79623	broad.mit.edu	37	chr2	31215732	31215732	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgagtgtccgggatggcccGattgctggagatccgctcac	6	8	15	12	4	1	1	1	0	0	1	3	5	3	2	3	3	1	2	3	3	0	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:31215732G>A	uc002rnr.2	-	2	890	c.271C>T	c.(271-273)CGG>TGG	p.R91W	GALNT14_uc002rnq.2_Missense_Mutation_p.R71W|GALNT14_uc002rns.2_Intron|GALNT14_uc010ymr.1_Missense_Mutation_p.R56W|GALNT14_uc010ezo.1_Missense_Mutation_p.R91W|GALNT14_uc010ezp.1_Missense_Mutation_p.R62W	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	91	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GGGATGGCCCGATTGCTGGAG	0.562													6	89					0	0	0	0	A	31215732	A	A	31215732	3	1	210	1	0	0	0	0	1	0	0	0	6247	1057	37	1	1443	1	GALNT14	2	31215732	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08		31215732	211983641	16	38248											
EFEMP1	2202	broad.mit.edu	37	chr2	56097911	56097911	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatccgaaaagtattgatggTgttggcataaatagttgtgg	13	13	12	3	1	0	1	0	1	0	0	1	2	1	1	1	3	0	4	1	3	7	6			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:56097911T>G	uc002rzh.2	-	10	1594	c.1264A>C	c.(1264-1266)ACC>CCC	p.T422P	EFEMP1_uc002rzi.2_Missense_Mutation_p.T422P|EFEMP1_uc002rzj.2_Missense_Mutation_p.T422P|EFEMP1_uc010ypc.1_Missense_Mutation_p.T284P	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	422	Mediates interaction with TIMP3.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GTATTGATGGTGTTGGCATAA	0.418													3	58					0	0	0	0	G	56097911	G	G	56097911	3	3	210	1	0	0	0	0	1	0	0	0	4963	1696	59	5	225	5	EFEMP1	2	56097911	Missense_Mutation	SNP	T	TCGA-CV-6955-01A-11D-2012-08	24882179	56097911	187101462	17	38249											
ARHGAP25	9938	broad.mit.edu	37	chr2	69049988	69049988	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacacagaagcaaatgtatGaggaacagattaaaaagtaa	23	6	8	4	0	0	3	0	1	0	2	0	4	0	4	0	1	3	3	0	1	9	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:69049988G>C	uc002seu.2	+	10	2078	c.1714G>C	c.(1714-1716)GAG>CAG	p.E572Q	ARHGAP25_uc010fdg.2_Missense_Mutation_p.E573Q|ARHGAP25_uc010yql.1_Missense_Mutation_p.E533Q|ARHGAP25_uc002sew.2_Missense_Mutation_p.E565Q|ARHGAP25_uc002sex.2_Missense_Mutation_p.E566Q|ARHGAP25_uc002sey.2_Missense_Mutation_p.E299Q	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	572	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						GCAAATGTATGAGGAACAGAT	0.448													3	54					0	0	0	0	C	69049988	C	C	69049988	3	2	210	1	0	0	0	0	1	0	0	0	874	1291	45	2	1795	2	ARHGAP25	2	69049988	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	12952077	69049988	174149385	18	38250											
PCGF1	84759	broad.mit.edu	37	chr2	74733102	74733102	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccgctccaggcacaggttCaactgctcatcatagcgata	11	8	9	13	2	3	0	3	0	0	0	4	1	4	0	2	2	4	4	2	2	3	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:74733102C>T	uc002slz.2	-	5	533	c.507G>A	c.(505-507)TTG>TTA	p.L169L	LBX2_uc002slw.2_5'Flank|PCGF1_uc002sly.2_Silent_p.L86L	NM_032673	NP_116062	Q9BSM1	PCGF1_HUMAN	polycomb group ring finger 1	169					histone H2A monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	protein C-terminus binding|zinc ion binding			ovary(1)	1						GGCACAGGTTCAACTGCTCAT	0.577													13	197					0	0	0	0	T	74733102	T	T	74733102	2	4	210	1	0	0	0	0	0	0	0	1	11628	825	29	2		2	PCGF1	2	74733102	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	5683114	74733102	168466271	19	38251											
GGCX	2677	broad.mit.edu	37	chr2	85781368	85781368	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggaaaccagctgagaggtCaagcagcagcccaccccagt	13	3	11	14	0	1	1	1	1	0	1	1	3	1	2	4	2	5	3	4	2	2	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:85781368C>G	uc002sps.2	-	7	893	c.787G>C	c.(787-789)GAC>CAC	p.D263H	GGCX_uc010yss.1_Missense_Mutation_p.D102H|GGCX_uc010yst.1_Missense_Mutation_p.D206H	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	263	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	GCTGAGAGGTCAAGCAGCAGC	0.507													6	183					0	0	0	0	G	85781368	G	G	85781368	3	3	210	1	0	0	0	0	1	0	0	0	6393	826	29	2	1525	2	GGCX	2	85781368	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	11048266	85781368	157418005	20	38252											
CKAP2L	150468	broad.mit.edu	37	chr2	113514726	113514726	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgggctggagtttaatgctGatggaccttttaggtttgac	7	15	13	6	0	0	2	0	2	0	0	0	4	0	4	1	4	1	4	1	4	2	5	rs77207496	byFrequency	TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:113514726G>C	uc002tie.2	-	4	301	c.222C>G	c.(220-222)ATC>ATG	p.I74M	CKAP2L_uc002tif.2_Translation_Start_Site|CKAP2L_uc010yxp.1_Translation_Start_Site|CKAP2L_uc010yxq.1_Translation_Start_Site	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	74						centrosome					0						GTTTAATGCTGATGGACCTTT	0.413													7	183					0	0	0	0	C	113514726	C	C	113514726	3	2	210	1	0	0	0	0	1	0	0	0	3458	1280	45	2	2039	2	CKAP2L	2	113514726	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	27733358	113514726	129684647	21	38253											
LRP1B	53353	broad.mit.edu	37	chr2	141250263	141250263	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattaaaaaaggttcttcatCtaaacaccaacacaaataac	21	9	2	9	0	3	0	1	0	2	0	3	0	3	0	1	1	3	1	1	1	9	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:141250263C>G	uc002tvj.1	-	57	10007	c.9035_splice	c.e57-1	p.D3012_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGTTCTTCATCTAAACACCAA	0.338										TSP Lung(27;0.18)			6	67					0	0	0	0	G	141250263	G	G	141250263	5	3	210	1	0	0	0	0	0	0	1	0	9005	927	32	2	4905	2	LRP1B	2	141250263	Splice_Site	SNP	C	TCGA-CV-6955-01A-11D-2012-08	27735537	141250263	101949110	22	38254											
NFE2L2	4780	broad.mit.edu	37	chr2	178098810	178098810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggagaaattcacctgtctCttcatctagttgtaactgag	10	14	9	8	0	4	2	2	1	2	1	5	3	4	2	1	1	1	2	1	1	3	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:178098810C>T	uc002ulh.3	-	2	790	c.235G>A	c.(235-237)GAG>AAG	p.E79K	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63K|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63K|NFE2L2_uc002uli.3_Missense_Mutation_p.E63K|NFE2L2_uc010fra.2_Missense_Mutation_p.E63K|NFE2L2_uc010frb.2_Missense_Mutation_p.E63K	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			5	58					0	0	0	0	T	178098810	T	T	178098810	3	4	210	1	0	0	0	0	1	0	0	0	10422	922	32	2	1598	2	NFE2L2	2	178098810	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	36848547	178098810	65100563	23	38255											
ARMC9	80210	broad.mit.edu	37	chr2	232123816	232123816	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgttgcaggctctgcgctggGtaggtacctttgtcttaaag	6	14	13	8	1	2	0	0	0	2	0	2	0	2	0	1	3	3	6	1	3	4	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr2:232123816G>A	uc002vrq.3	+	11	1138	c.1026_splice	c.e11+1	p.W342_splice	ARMC9_uc002vrp.3_Splice_Site_p.W342_splice	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9								binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		TCTGCGCTGGGTAGGTACCTT	0.438													11	27					0	0	0	0	A	232123816	A	A	232123816	5	1	210	1	0	0	0	0	0	0	1	0	960	1275	44	4	1065	4	ARMC9	2	232123816	Splice_Site	SNP	G	TCGA-CV-6955-01A-11D-2012-08	54025006	232123816	11075557	24	38256											
TGFBR2	7048	broad.mit.edu	37	chr3	30715720	30715720	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgctctgggaaatgacatctCgctgtaatgcagtgggaggt	9	11	14	7	1	2	1	0	1	2	0	3	3	2	3	0	3	2	4	0	3	2	1	rs104893811		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:30715720C>T	uc003ceo.2	+	5	1760	c.1378C>T	c.(1378-1380)CGC>TGC	p.R460C	TGFBR2_uc003cen.2_Missense_Mutation_p.R485C	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	460	Protein kinase.|Cytoplasmic (Potential).		R -> C (in AAT3).|R -> H (in AAT3).		activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						AATGACATCTCGCTGTAATGC	0.458													7	63					0	0	0	0	T	30715720	T	T	30715720	3	4	210	1	0	0	0	0	1	0	0	0	15888	884	31	1	1475	1	TGFBR2	3	30715720	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08		30715720	167306710	25	38257											
ATRIP	84126	broad.mit.edu	37	chr3	48488144	48488144	+	5'Flank	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgggccaggggcggggcactCgcggcggaggcaagcggcgg	5	2	23	11	6	0	0	0	0	0	0	1	1	0	1	1	10	1	2	1	10	1	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:48488144C>G	uc003ctf.1	+						ATRIP_uc011bbj.1_5'UTR|ATRIP_uc003ctg.1_5'Flank	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1						DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCGGGGCACTCGCGGCGGAGG	0.746								Other_conserved_DNA_damage_response_genes					3	23					0	0	0	0	G	48488144	G	G	48488144	1	3	210	0	1	0	0	0	0	0	0	0	1207	899	31	3		3	ATRIP	3	48488144	5'Flank	SNP	C	TCGA-CV-6955-01A-11D-2012-08	17772424	48488144	149534286	26	38258											
ITIH4	3700	broad.mit.edu	37	chr3	52857598	52857598	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccactgactgtggctgtgaGcacatcaggcccccggtcct	6	8	11	16	1	1	2	1	2	0	0	2	2	2	2	4	3	1	2	4	3	0	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:52857598G>T	uc003dfz.2	-	11	1549	c.1513C>A	c.(1513-1515)CTC>ATC	p.L505I	ITIH4_uc011bel.1_Missense_Mutation_p.L235I|ITIH4_uc003dfy.2_Missense_Mutation_p.L369I|ITIH4_uc011bem.1_Missense_Mutation_p.L505I|ITIH4_uc011ben.1_Missense_Mutation_p.L505I	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	505					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GTGGCTGTGAGCACATCAGGC	0.612													8	22					0.000157383	0.000171189	1	0	T	52857598	T	T	52857598	3	4	210	1	0	0	0	0	1	0	0	0	7945	971	34	4	1335	4	ITIH4	3	52857598	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	4369454	52857598	145164832	27	38259											
CACNA1D	776	broad.mit.edu	37	chr3	53844020	53844020	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcagatcatggcagttgccGgcctagattcaagtaaagcc	11	9	10	11	1	3	2	3	0	0	2	3	2	3	2	3	2	2	3	3	2	4	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:53844020G>A	uc003dgv.3	+	47	6050	c.5887G>A	c.(5887-5889)GGC>AGC	p.G1963S	CACNA1D_uc003dgu.3_Missense_Mutation_p.G1983S|CACNA1D_uc003dgy.3_Missense_Mutation_p.G1939S|CACNA1D_uc003dgw.3_Missense_Mutation_p.G1630S|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1963	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGCAGTTGCCGGCCTAGATTC	0.612													16	73					0	0	0	0	A	53844020	A	A	53844020	3	1	210	1	0	0	0	0	1	0	0	0	2553	1116	39	1	6245	1	CACNA1D	3	53844020	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	986422	53844020	144178410	28	38260											
C3orf38	285237	broad.mit.edu	37	chr3	88205752	88205752	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtacgacataatgtaaagcaGgcttcggatagtggaactgg	13	9	13	6	2	0	0	0	0	0	0	1	3	0	2	0	4	3	4	0	4	6	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:88205752G>A	uc003dqw.2	+	4	1268	c.957G>A	c.(955-957)CAG>CAA	p.Q319Q		NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	319					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		ATGTAAAGCAGGCTTCGGATA	0.408													20	70					0	0	0	0	A	88205752	A	A	88205752	2	1	210	1	0	0	0	0	0	0	0	1	2238	991	35	4		4	C3orf38	3	88205752	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	34361732	88205752	109816678	29	38261											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	50					0	0	0	0	A	178936082	A	A	178936082	3	1	210	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	90730330	178936082	19086348	30	38262											
ZBTB49	166793	broad.mit.edu	37	chr4	4314793	4314793	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taacttgcagactcacttacGacggcattctggtgaaaaac	13	10	8	10	2	2	2	1	1	1	1	2	3	2	2	0	2	4	2	0	2	4	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:4314793G>A	uc003ghu.2	+	5	1503	c.1328G>A	c.(1327-1329)CGA>CAA	p.R443Q	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_Intron|ZBTB49_uc010icz.2_Intron	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	443	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						ACTCACTTACGACGGCATTCT	0.408													7	50					0	0	0	0	A	4314793	A	A	4314793	3	1	210	1	0	0	0	0	1	0	0	0	17617	1058	37	1	1342	1	ZBTB49	4	4314793	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08		4314793	186839483	31	38263											
EVC	2121	broad.mit.edu	37	chr4	5800433	5800433	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcttctgcagcagcacAtggagtgcgccattgggcag	8	7	15	11	1	1	0	0	0	1	0	1	1	1	1	1	3	5	6	1	3	0	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:5800433A>G	uc003gil.1	+	15	2402	c.2218A>G	c.(2218-2220)ATG>GTG	p.M740V	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	740					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				GCAGCAGCACATGGAGTGCGC	0.652													6	15					0	0	0	0	G	5800433	G	G	5800433	3	3	210	1	0	0	0	0	1	0	0	0	5309	217	8	5	2276	5	EVC	4	5800433	Missense_Mutation	SNP	A	TCGA-CV-6955-01A-11D-2012-08	1485640	5800433	185353843	32	38264											
AFAP1	60312	broad.mit.edu	37	chr4	7873772	7873772	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatggtccaggagttcaaGaaagagacgaagttcaacta	15	9	10	7	1	3	2	3	0	0	2	4	5	4	3	1	2	1	2	1	2	5	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:7873772G>C	uc003gkg.1	-	2	307	c.34C>G	c.(34-36)CTT>GTT	p.L12V	AFAP1_uc011bwk.1_Missense_Mutation_p.L12V	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	12						actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						AGGAGTTCAAGAAAGAGACGA	0.383													3	61					0	0	0	0	C	7873772	C	C	7873772	3	2	210	1	0	0	0	0	1	0	0	0	353	942	33	2	2478	2	AFAP1	4	7873772	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	2073339	7873772	183280504	33	38265											
SOD3	6649	broad.mit.edu	37	chr4	24801554	24801554	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactacaacccgctggccgtGccgcacccgcagcacccggg	7	3	11	20	5	0	0	0	0	0	0	0	0	0	0	5	2	4	4	5	2	2	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:24801554G>C	uc003gqz.2	+	2	616	c.411G>C	c.(409-411)GTG>GTC	p.V137V	SOD3_uc003gqy.1_RNA	NM_003102	NP_003093	P08294	SODE_HUMAN	superoxide dismutase 3, extracellular precursor	137					removal of superoxide radicals	extracellular space|nucleus|soluble fraction	copper ion binding|heparin binding|protein binding|superoxide dismutase activity|zinc ion binding				0		Breast(46;0.0503)				CGCTGGCCGTGCCGCACCCGC	0.751													4	26					0	0	0	0	C	24801554	C	C	24801554	2	2	210	1	0	0	0	0	0	0	0	1	14986	1306	46	4		4	SOD3	4	24801554	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	16927782	24801554	166352722	34	38266											
ADAD1	132612	broad.mit.edu	37	chr4	123336584	123336584	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagaaatcgctataaagcaaCgtgttgatgatgcactcact	14	11	8	8	2	1	3	1	2	0	1	2	3	1	3	0	0	3	4	0	0	6	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:123336584C>T	uc003ieo.2	+	11	1532	c.1300C>T	c.(1300-1302)CGT>TGT	p.R434C	ADAD1_uc003iep.2_Missense_Mutation_p.R423C|ADAD1_uc003ieq.2_Missense_Mutation_p.R416C	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	434	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						TATAAAGCAACGTGTTGATGA	0.368													15	75					0	0	0	0	T	123336584	T	T	123336584	3	4	210	1	0	0	0	0	1	0	0	0	231	536	19	1	1334	1	ADAD1	4	123336584	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	98535030	123336584	67817692	35	38267											
FAT1	2195	broad.mit.edu	37	chr4	187539957	187539959	+	In_Frame_Del	DEL	GTG	-	-																															gtatttggttgctcgaaattGtggtgcattgtcattgtcat																										TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:187539957_187539959delGTG	uc003izf.2	-	10	7969_7971	c.7781_7783delCAC	c.(7780-7785)CCACAA>CAA	p.P2594del		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2594	Extracellular (Potential).|Cadherin 23.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCTCGAAATTGTGGTGCATTGTC	0.453										HNSCC(5;0.00058)			---	---	---								-	187539959	-	-	187539957	7	5	210	1	0	1	0	1	0	0	0	0	5721	1386	48	0	6055	0	FAT1	4	187539957	In_Frame_Del	DEL	GTG	TCGA-CV-6955-01A-11D-2012-08	64203373	187539957	3614319	36	38268											
FAT1	2195	broad.mit.edu	37	chr4	187629100	187629100	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taagccatccattagcgatcGctttaatgacaatacccccg	12	10	6	13	3	0	1	0	1	0	0	2	2	1	1	4	0	3	1	4	0	5	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:187629100G>A	uc003izf.2	-	2	2070	c.1882C>T	c.(1882-1884)CGA>TGA	p.R628*	FAT1_uc010iso.1_Nonsense_Mutation_p.R628*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	628	Extracellular (Potential).|Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATTAGCGATCGCTTTAATGAC	0.403										HNSCC(5;0.00058)			6	63					0	0	0	0	A	187629100	A	A	187629100	4	1	210	1	0	0	0	0	0	1	0	0	5721	1095	38	1	11988	1	FAT1	4	187629100	Nonsense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	89143	187629100	3525176	37	38269											
FAT1	2195	broad.mit.edu	37	chr4	187630411	187630411	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatagcaaacatatctgttcGatctttaaaactgtagtaaa	17	13	5	6	1	2	0	0	0	2	0	3	1	2	0	0	0	3	4	0	0	9	7			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr4:187630411G>A	uc003izf.2	-	2	759	c.571C>T	c.(571-573)CGA>TGA	p.R191*	FAT1_uc010iso.1_Nonsense_Mutation_p.R191*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	191	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATATCTGTTCGATCTTTAAAA	0.433										HNSCC(5;0.00058)			13	115					0	0	0	0	A	187630411	A	A	187630411	4	1	210	1	0	0	0	0	0	1	0	0	5721	1066	37	1	13299	1	FAT1	4	187630411	Nonsense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	1311	187630411	3523865	38	38270											
MIER3	166968	broad.mit.edu	37	chr5	56234739	56234739	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcatgtctggtagttcatCtgccagttcacttggggaac	7	14	11	9	0	5	0	3	0	2	0	5	1	5	1	1	3	2	3	1	3	2	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:56234739C>G	uc003jrd.1	-	4	311	c.286G>C	c.(286-288)GAT>CAT	p.D96H	MIER3_uc003jqz.1_Missense_Mutation_p.D33H|MIER3_uc003jra.1_Missense_Mutation_p.D96H|MIER3_uc003jrb.1_5'UTR|MIER3_uc003jrc.1_Missense_Mutation_p.D101H	NM_152622	NP_689835	Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		GGTAGTTCATCTGCCAGTTCA	0.393													6	63					0	0	0	0	G	56234739	G	G	56234739	3	3	210	1	0	0	0	0	1	0	0	0	9635	913	32	2	1403	2	MIER3	5	56234739	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08		56234739	124680521	39	38271											
SERINC5	256987	broad.mit.edu	37	chr5	79473175	79473175	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatctggaatgaagaaagctCctgagcacatggcccccaac	13	6	10	12	0	1	3	0	2	1	1	2	5	2	4	3	2	3	2	3	2	4	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:79473175C>T	uc003kgj.2	-	4	548	c.419G>A	c.(418-420)GGA>GAA	p.G140E	SERINC5_uc003kgk.2_Missense_Mutation_p.G140E|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.G140E|SERINC5_uc011ctj.1_Missense_Mutation_p.G140E	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	140	Helical; (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GAAGAAAGCTCCTGAGCACAT	0.393													6	58					0	0	0	0	T	79473175	T	T	79473175	3	4	210	1	0	0	0	0	1	0	0	0	14148	855	30	2	1040	2	SERINC5	5	79473175	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	23238436	79473175	101442085	40	38272											
C5orf13	9315	broad.mit.edu	37	chr5	111066653	111066653	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtaactgattcttggggagcGgagttcactgctgcccagtg	7	11	14	9	1	2	1	1	1	1	0	2	3	2	3	1	3	4	3	1	3	1	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:111066653G>A	uc003kpl.2	-	3	651	c.172C>T	c.(172-174)CGC>TGC	p.R58C	C5orf13_uc011cvr.1_Missense_Mutation_p.R102C|C5orf13_uc011cvs.1_Missense_Mutation_p.R92C|C5orf13_uc003kpk.2_Intron|C5orf13_uc003kpm.2_Missense_Mutation_p.R58C|C5orf13_uc011cvk.1_Missense_Mutation_p.R58C|C5orf13_uc011cvl.1_Missense_Mutation_p.R58C|C5orf13_uc011cvm.1_Missense_Mutation_p.R58C|C5orf13_uc011cvn.1_Missense_Mutation_p.R58C|C5orf13_uc011cvo.1_Missense_Mutation_p.R58C|C5orf13_uc011cvp.1_Missense_Mutation_p.R58C|C5orf13_uc011cvq.1_Missense_Mutation_p.R58C	NM_001142483	NP_001135955	Q16612	NP311_HUMAN	neuronal protein 3.1 isoform a	58						cytoplasm				skin(1)	1		all_cancers(142;0.00597)|all_epithelial(76;0.000144)|Prostate(80;0.0115)|Colorectal(10;0.0446)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;5.45e-09)|Epithelial(69;2e-08)|all cancers(49;1.9e-06)|COAD - Colon adenocarcinoma(37;0.0514)|Colorectal(14;0.0629)		CTTGGGGAGCGGAGTTCACTG	0.458													26	82					0	0	0	0	A	111066653	A	A	111066653	3	1	210	1	0	0	0	0	1	0	0	0	2292	1116	39	1	38	1	C5orf13	5	111066653	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	31593478	111066653	69848607	41	38273											
PCDHGB5	56101	broad.mit.edu	37	chr5	140778900	140778900	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcgtataagttggtaacAgatggaaccctagaccgaga	15	9	10	7	2	0	3	0	0	0	3	1	5	0	4	2	2	2	3	2	2	6	6			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:140778900A>T	uc003lkf.1	+	1	1206	c.1206A>T	c.(1204-1206)ACA>ACT	p.T402T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.T402T	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	402	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTGGTAACAGATGGAACCC	0.478													9	45					0	0	0	0	T	140778900	T	T	140778900	2	4	210	1	0	0	0	0	0	0	0	1	11620	175	7	5		5	PCDHGB5	5	140778900	Silent	SNP	A	TCGA-CV-6955-01A-11D-2012-08	29712247	140778900	40136360	42	38274											
PCDHGB7	56099	broad.mit.edu	37	chr5	140799566	140799566	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgattctagctattgctctaCgcctgcgacagtctttcagc	7	14	8	12	2	4	1	1	1	3	0	4	2	4	1	1	0	5	2	1	0	3	6			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:140799566C>T	uc003lkn.1	+	1	2285	c.2140C>T	c.(2140-2142)CGC>TGC	p.R714C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.R714C|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	714	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATTGCTCTACGCCTGCGACA	0.552													26	54					0	0	0	0	T	140799566	T	T	140799566	3	4	210	1	0	0	0	0	1	0	0	0	11622	536	19	1	2142	1	PCDHGB7	5	140799566	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	20666	140799566	40115694	43	38275											
PCDHGA12	26025	broad.mit.edu	37	chr5	140810887	140810887	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgtgcaaaatggagccgaCggtagtaagtaccccgaatt	13	8	11	9	4	0	0	0	0	0	0	1	3	0	1	3	2	3	4	3	2	6	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:140810887C>T	uc003lkt.1	+	1	730	c.561C>T	c.(559-561)GAC>GAT	p.D187D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Silent_p.D187D	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	187	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGGAGCCGACGGTAGTAAGT	0.607													9	132					0	0	0	0	T	140810887	T	T	140810887	2	4	210	1	0	0	0	0	0	0	0	1	11607	535	19	1		1	PCDHGA12	5	140810887	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	11321	140810887	40104373	44	38276											
FAT2	2196	broad.mit.edu	37	chr5	150924152	150924153	+	Frame_Shift_Ins	INS	-	T	T																															ggtgatattttcaggtactcINStgactttgtaataaggactc																										TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:150924152_150924153insT	uc003lue.3	-	9	6548_6549	c.6535_6536insA	c.(6535-6537)AGAfs	p.R2179fs	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2179	Cadherin 19.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAGGTACTCTGACTTTGTAA	0.5													---	---	---								T	150924153	T	T	150924152	7	5	210	1	0	1	1	0	0	0	0	0	5722	913	32	0	6573	0	FAT2	5	150924152	Frame_Shift_Ins	INS	-	TCGA-CV-6955-01A-11D-2012-08	10113265	150924152	29991108	45	38277											
ATP10B	23120	broad.mit.edu	37	chr5	160033923	160033923	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttccctggaagatggcattCaatgtcttcccatcgatgac	9	13	8	11	1	2	2	1	1	1	1	5	4	4	3	2	2	0	1	2	2	2	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr5:160033923C>T	uc003lym.1	-	19	3856	c.3009G>A	c.(3007-3009)TTG>TTA	p.L1003L	ATP10B_uc010jit.1_Silent_p.L320L	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1003	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATGGCATTCAATGTCTTCC	0.512													5	111					0	0	0	0	T	160033923	T	T	160033923	2	4	210	1	0	0	0	0	0	0	0	1	1119	825	29	2		2	ATP10B	5	160033923	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	9109771	160033923	20881337	46	38278											
FOXQ1	94234	broad.mit.edu	37	chr6	1313527	1313527	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggacaactactggatgctCaaccccaacagcgagtacac	15	5	8	13	1	1	0	1	0	0	0	1	3	1	2	2	2	7	2	2	2	6	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:1313527C>G	uc003mtl.3	+	1	853	c.588C>G	c.(586-588)CTC>CTG	p.L196L		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	196	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		ACTGGATGCTCAACCCCAACA	0.547													3	62					0	0	0	0	G	1313527	G	G	1313527	2	3	210	1	0	0	0	0	0	0	0	1	6064	813	29	2		2	FOXQ1	6	1313527	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08		1313527	169801540	47	38279											
SIRT5	23408	broad.mit.edu	37	chr6	13601120	13601120	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttgccccccaggtggctGccaggggcgtgccagtggct	3	9	16	13	1	0	0	0	0	0	0	0	0	0	0	5	5	3	3	5	5	0	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:13601120G>T	uc003nay.2	+	9	1092	c.796G>T	c.(796-798)GCC>TCC	p.A266S	SIRT5_uc003naw.2_Missense_Mutation_p.A266S|SIRT5_uc003nax.2_Missense_Mutation_p.A158S|SIRT5_uc011dit.1_Missense_Mutation_p.A248S	NM_012241	NP_036373	Q9NXA8	SIRT5_HUMAN	sirtuin 5 isoform 1	266	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	CCAGGTGGCTGCCAGGGGCGT	0.577													7	39					0.000274275	0.000294885	1	0	T	13601120	T	T	13601120	3	4	210	1	0	0	0	0	1	0	0	0	14406	1319	46	4	822	4	SIRT5	6	13601120	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	12287593	13601120	157513947	48	38280											
RBM24	221662	broad.mit.edu	37	chr6	17291995	17291995	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atttctcaacaggatacctgCccactatgtctatccgcagg	10	11	7	13	1	2	0	1	0	2	0	4	1	3	1	3	2	3	1	3	2	4	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:17291995C>T	uc003nbz.3	+	4	360	c.356C>T	c.(355-357)GCC>GTC	p.A119V	RBM24_uc003nby.3_3'UTR|RBM24_uc011dix.1_Missense_Mutation_p.A61V|RBM24_uc003nca.2_Missense_Mutation_p.A74V|RBM24_uc011diy.1_Missense_Mutation_p.P33S|RBM24_uc011diz.1_Missense_Mutation_p.P18S	NM_001143942	NP_001137414	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24 isoform 1	119					cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			ovary(1)|skin(1)	2	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)			AGGATACCTGCCCACTATGTC	0.483													26	162					0	0	0	0	T	17291995	T	T	17291995	3	4	210	1	0	0	0	0	1	0	0	0	13189	739	26	4	403	4	RBM24	6	17291995	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	3690875	17291995	153823072	49	38281											
ETV7	51513	broad.mit.edu	37	chr6	36334462	36334462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttgtccttgaactctattCtgtcctgctcctggctctcc	3	17	6	15	0	4	1	0	1	4	0	8	1	7	1	4	1	2	2	4	1	2	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:36334462C>T	uc003omb.2	-	8	1135	c.986G>A	c.(985-987)AGA>AAA	p.R329K	ETV7_uc003olz.1_Intron|ETV7_uc003oma.1_Intron|ETV7_uc010jwg.2_RNA|ETV7_uc003omc.2_Missense_Mutation_p.R274K|ETV7_uc010jwj.2_Missense_Mutation_p.R270K|ETV7_uc010jwh.2_Missense_Mutation_p.R248K|ETV7_uc010jwi.2_Missense_Mutation_p.R252K|ETV7_uc011dtl.1_Missense_Mutation_p.R178K	NM_016135	NP_057219	Q9Y603	ETV7_HUMAN	ets variant 7	329					organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GAACTCTATTCTGTCCTGCTC	0.577													6	149					0	0	0	0	T	36334462	T	T	36334462	3	4	210	1	0	0	0	0	1	0	0	0	5308	913	32	2	43	2	ETV7	6	36334462	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	19042467	36334462	134780605	50	38282											
UTRN	7402	broad.mit.edu	37	chr6	145103095	145103095	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtacaacaaatgaaattttCaaacagcacaagttgaacca	20	8	5	8	0	1	2	1	2	0	0	1	2	1	2	1	0	5	3	1	0	7	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:145103095C>G	uc003qkt.2	+	60	8762	c.8670C>G	c.(8668-8670)TTC>TTG	p.F2890L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2890	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATGAAATTTTCAAACAGCACA	0.338													4	37					0	0	0	0	G	145103095	G	G	145103095	3	3	210	1	0	0	0	0	1	0	0	0	17171	825	29	2	8908	2	UTRN	6	145103095	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	108768633	145103095	26011972	51	38283											
SYNE1	23345	broad.mit.edu	37	chr6	152841678	152841678	+	Splice_Site	DEL	C	-	-																															cggcgtccttgttcacaaggCtgtaaaaagtggggtaaaaa																										TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:152841678delC	uc010kiw.2	-	6	828	c.226_splice	c.e6-1	p.P76_splice	SYNE1_uc003qot.3_Splice_Site_p.P76_splice|SYNE1_uc003qou.3_Splice_Site_p.P76_splice|SYNE1_uc010kjb.1_Splice_Site_p.P76_splice|SYNE1_uc003qpa.1_Splice_Site_p.P76_splice	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTTCACAAGGCTGTAAAAAGT	0.368										HNSCC(10;0.0054)			---	---	---								-	152841678	-	-	152841678	8	5	210	1	0	1	0	1	0	0	1	0	15511	811	28	0	26830	0	SYNE1	6	152841678	Splice_Site	DEL	C	TCGA-CV-6955-01A-11D-2012-08	7738583	152841678	18273389	52	38284											
RGS17	26575	broad.mit.edu	37	chr6	153347617	153347617	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taggacctggatactctccaTttttgtagtgtgtgtgggtc	6	16	12	7	0	1	0	0	0	1	0	3	2	1	2	2	3	1	1	2	3	3	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:153347617T>G	uc003qpm.2	-	3	337	c.181A>C	c.(181-183)ATG>CTG	p.M61L		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	61					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		ATACTCTCCATTTTTGTAGTG	0.413									Lung_Cancer_Familial_Clustering_of				31	79					0	0	0	0	G	153347617	G	G	153347617	3	3	210	1	0	0	0	0	1	0	0	0	13364	1493	52	5	463	5	RGS17	6	153347617	Missense_Mutation	SNP	T	TCGA-CV-6955-01A-11D-2012-08	505939	153347617	17767450	53	38285											
SERAC1	84947	broad.mit.edu	37	chr6	158565392	158565392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagatcactctcttcgcttCgtgccaaaccaataagagtt	12	11	7	11	2	2	2	1	0	1	2	5	3	2	2	2	0	2	2	2	0	4	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:158565392C>T	uc003qrc.2	-	7	690	c.548G>A	c.(547-549)CGA>CAA	p.R183Q	SERAC1_uc003qrb.2_5'UTR	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	183					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		CTCTTCGCTTCGTGCCAAACC	0.338													4	47					0	0	0	0	T	158565392	T	T	158565392	3	4	210	1	0	0	0	0	1	0	0	0	14139	884	31	1	1460	1	SERAC1	6	158565392	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	5217775	158565392	12549675	54	38286											
THBS2	7058	broad.mit.edu	37	chr6	169648845	169648845	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcccctggacttgccgtcCtgcttgagctgggccgtgag	3	10	15	13	2	0	2	0	2	0	0	1	3	1	3	5	2	4	2	5	2	0	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr6:169648845C>G	uc003qwt.2	-	4	524	c.276G>C	c.(274-276)CAG>CAC	p.Q92H		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	92	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		ACTTGCCGTCCTGCTTGAGCT	0.622													8	65					0	0	0	0	G	169648845	G	G	169648845	3	3	210	1	0	0	0	0	1	0	0	0	15920	680	24	4	3322	4	THBS2	6	169648845	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	11083453	169648845	1466222	55	38287											
EIF2AK1	27102	broad.mit.edu	37	chr7	6085734	6085734	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttttagttgcacccttaaTcaggattttttttattgcat	8	21	6	6	0	1	0	1	0	0	0	1	1	1	1	1	1	2	4	1	1	3	9			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:6085734T>A	uc003spp.2	-	6	744	c.598A>T	c.(598-600)ATT>TTT	p.I200F	EIF2AK1_uc003spq.2_Missense_Mutation_p.I200F|EIF2AK1_uc011jwm.1_Missense_Mutation_p.I76F|EIF2AK1_uc003spr.1_5'UTR	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	200	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		GCACCCTTAATCAGGATTTTT	0.254													5	21					0	0	0	0	A	6085734	A	A	6085734	3	1	210	1	0	0	0	0	1	0	0	0	5018	1435	50	5	1334	5	EIF2AK1	7	6085734	Missense_Mutation	SNP	T	TCGA-CV-6955-01A-11D-2012-08		6085734	153052929	56	38288											
TMEM195	392636	broad.mit.edu	37	chr7	15240926	15240926	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggttatttccaagggtgaGaggtgagttgtttcatgctt	8	15	13	5	0	1	2	1	2	0	1	2	3	2	2	1	3	1	4	1	3	2	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:15240926G>C	uc003stb.1	-	13	1492	c.1322C>G	c.(1321-1323)TCT>TGT	p.S441C		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	441					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						CCAAGGGTGAGAGGTGAGTTG	0.308													8	47					0	0	0	0	C	15240926	C	C	15240926	3	2	210	1	0	0	0	0	1	0	0	0	16183	942	33	2	19	2	TMEM195	7	15240926	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	9155192	15240926	143897737	57	38289											
CACNA2D1	781	broad.mit.edu	37	chr7	81714097	81714097	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacctacctggataatatcGagctaggccagtggcactgc	10	8	11	12	1	0	0	0	0	0	0	1	2	0	1	3	3	3	3	3	3	4	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:81714097G>A	uc003uhr.1	-	7	902	c.646C>T	c.(646-648)CGA>TGA	p.R216*		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	216	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GGATAATATCGAGCTAGGCCA	0.423													13	45					0	0	0	0	A	81714097	A	A	81714097	4	1	210	1	0	0	0	0	0	1	0	0	2560	1066	37	1	2761	1	CACNA2D1	7	81714097	Nonsense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	66473171	81714097	77424566	58	38290											
TMEM130	222865	broad.mit.edu	37	chr7	98446224	98446224	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctccaccatgtccttttgCtgagtggcattccgcagggt	6	12	10	13	1	0	1	0	1	0	0	3	1	3	1	5	2	1	3	5	2	0	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:98446224C>T	uc003upo.2	-	7	1290	c.1101G>A	c.(1099-1101)CAG>CAA	p.Q367Q	TMEM130_uc011kiq.1_Silent_p.Q348Q|TMEM130_uc011kir.1_Silent_p.Q367Q|TMEM130_uc003upn.2_Silent_p.Q265Q	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	367	Cytoplasmic (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGTCCTTTTGCTGAGTGGCAT	0.557													13	67					0	0	0	0	T	98446224	T	T	98446224	2	4	210	1	0	0	0	0	0	0	0	1	16109	796	28	4		4	TMEM130	7	98446224	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	16732127	98446224	60692439	59	38291											
PTCD1	26024	broad.mit.edu	37	chr7	99027337	99027337	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgccggagcttcagggcgctCtgtagagctgagtccttcca	6	10	13	12	2	2	2	1	1	1	1	4	3	4	3	3	2	3	4	3	2	1	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:99027337C>G	uc003uqh.2	-	4	818	c.687G>C	c.(685-687)CAG>CAC	p.Q229H	PTCD1_uc011kiw.1_Missense_Mutation_p.Q278H	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	229	PPR 3.									ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCAGGGCGCTCTGTAGAGCTG	0.597													4	63					0	0	0	0	G	99027337	G	G	99027337	3	3	210	1	0	0	0	0	1	0	0	0	12789	912	32	2	1435	2	PTCD1	7	99027337	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	581113	99027337	60111326	60	38292											
ZSCAN21	7589	broad.mit.edu	37	chr7	99654858	99654858	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgtgagtggctgaggcccGagatccacaccaaggagcag	10	5	15	11	1	0	3	0	2	0	1	1	5	1	4	3	3	1	3	3	3	1	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:99654858G>A	uc003uso.2	+	2	373	c.229G>A	c.(229-231)GAG>AAG	p.E77K	ZSCAN21_uc011kje.1_Missense_Mutation_p.E76K|ZSCAN21_uc003usn.1_Missense_Mutation_p.E76K	NM_145914	NP_666019	Q9Y5A6	ZSC21_HUMAN	zinc finger protein 38	77	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GCTGAGGCCCGAGATCCACAC	0.637													5	40					0	0	0	0	A	99654858	A	A	99654858	3	1	210	1	0	0	0	0	1	0	0	0	18300	1059	37	1	231	1	ZSCAN21	7	99654858	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	627521	99654858	59483805	61	38293											
EPO	2056	broad.mit.edu	37	chr7	100320365	100320365	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgcggggccaggccctgttgGtcaactcttcccagccgtgg	4	9	14	14	2	2	0	1	0	1	0	3	0	3	0	4	5	3	1	4	5	1	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:100320365G>C	uc003uwi.2	+	4	506	c.325G>C	c.(325-327)GTC>CTC	p.V109L	EPO_uc011kkc.1_Missense_Mutation_p.V109L	NM_000799	NP_000790	P01588	EPO_HUMAN	erythropoietin precursor	109					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	GGCCCTGTTGGTCAACTCTTC	0.657													3	61					0	0	0	0	C	100320365	C	C	100320365	3	2	210	1	0	0	0	0	1	0	0	0	5212	1261	44	4	339	4	EPO	7	100320365	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	665507	100320365	58818298	62	38294											
CUX1	1523	broad.mit.edu	37	chr7	101838850	101838850	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcgctgcagtccgagaacGccgcgctgcgcatctccaac	7	6	11	17	6	1	1	0	0	1	1	4	2	2	1	3	0	4	5	3	0	2	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:101838850G>A	uc003uyx.3	+	14	1227	c.1189G>A	c.(1189-1191)GCC>ACC	p.A397T	CUX1_uc003uys.3_Missense_Mutation_p.A408T|CUX1_uc003uyt.2_Missense_Mutation_p.A408T|CUX1_uc011kkn.1_Missense_Mutation_p.A369T|CUX1_uc003uyw.2_Missense_Mutation_p.A362T|CUX1_uc003uyv.2_Missense_Mutation_p.A392T|CUX1_uc003uyu.2_Missense_Mutation_p.A406T	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	397					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GTCCGAGAACGCCGCGCTGCG	0.682													6	33					0	0	0	0	A	101838850	A	A	101838850	3	1	210	1	0	0	0	0	1	0	0	0	4081	1087	38	1	1310	1	CUX1	7	101838850	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	1518485	101838850	57299813	63	38295											
FEZF1	389549	broad.mit.edu	37	chr7	121942917	121942917	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgtagcccgcgtgtattcgGgtatgagtgtttaaagtgga	8	14	14	5	3	0	1	0	1	0	0	1	2	0	2	1	2	1	4	1	2	5	7			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:121942917G>A	uc003vkd.2	-	3	1079	c.1005C>T	c.(1003-1005)ACC>ACT	p.T335T	FEZF1_uc003vkc.2_Silent_p.T285T|uc010lko.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	335	C2H2-type 3.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						CGTGTATTCGGGTATGAGTGT	0.408													26	62					0	0	0	0	A	121942917	A	A	121942917	2	1	210	1	0	0	0	0	0	0	0	1	5857	1219	43	4		4	FEZF1	7	121942917	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	20104067	121942917	37195746	64	38296											
TAS2R41	259287	broad.mit.edu	37	chr7	143175518	143175518	+	Frame_Shift_Del	DEL	A	-	-																															catactatttcccatccctgAaactggtcatctggtcaatt																										TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:143175518delA	uc003wdc.1	+	1	553	c.553delA	c.(553-555)AAAfs	p.K185fs	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	185	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					CCCATCCCTGAAACTGGTCAT	0.368													---	---	---								-	143175518	-	-	143175518	7	5	210	1	0	1	0	1	0	0	0	0	15645	247	9	0	555	0	TAS2R41	7	143175518	Frame_Shift_Del	DEL	A	TCGA-CV-6955-01A-11D-2012-08	21232601	143175518	15963145	65	38297											
ZNF786	136051	broad.mit.edu	37	chr7	148777738	148777738	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatgcttgtaaagttccttCtgccatgcctctagatcctg	8	14	7	12	0	2	1	0	0	2	1	4	1	4	1	4	0	3	3	4	0	3	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr7:148777738C>G	uc003wfh.2	-	2	227	c.90G>C	c.(88-90)CAG>CAC	p.Q30H	ZNF786_uc011kuk.1_5'UTR|ZNF786_uc003wfi.2_Intron	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	30	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			AAAGTTCCTTCTGCCATGCCT	0.428													3	55					0	0	0	0	G	148777738	G	G	148777738	3	3	210	1	0	0	0	0	1	0	0	0	18225	912	32	2	2270	2	ZNF786	7	148777738	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	5602220	148777738	10360925	66	38298											
AMAC1L2	83650	broad.mit.edu	37	chr8	11188846	11188846	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gagctgctcatctgtcgatgCctcttccacctccctattgc	5	13	7	16	1	3	0	1	0	2	0	6	2	5	0	4	0	4	2	4	0	1	3	rs148317481		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:11188846C>T	uc003wtp.1	+	1	352	c.231C>T	c.(229-231)TGC>TGT	p.C77C		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	77	DUF6 1.|Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		TCTGTCGATGCCTCTTCCACC	0.627													29	246					0	0	0	0	T	11188846	T	T	11188846	2	4	210	1	0	0	0	0	0	0	0	1	560	747	26	4		4	AMAC1L2	8	11188846	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08		11188846	135175176	67	38299											
WHSC1L1	54904	broad.mit.edu	37	chr8	38148029	38148029	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttaatactagtctgcccttCagcaaagcttttgtctcctt	8	16	6	11	0	3	0	1	0	2	0	4	0	3	0	2	0	4	3	2	0	4	7			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:38148029C>T	uc003xli.2	-	17	3600	c.3082G>A	c.(3082-3084)GAA>AAA	p.E1028K	WHSC1L1_uc011lbm.1_Missense_Mutation_p.E1028K|WHSC1L1_uc010lwe.2_Missense_Mutation_p.E979K	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	1028					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			GTCTGCCCTTCAGCAAAGCTT	0.443			T	NUP98	AML								8	171					0	0	0	0	T	38148029	T	T	38148029	3	4	210	1	0	0	0	0	1	0	0	0	17431	835	29	2	1263	2	WHSC1L1	8	38148029	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	26959183	38148029	108215993	68	38300											
ZFHX4	79776	broad.mit.edu	37	chr8	77618162	77618162	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctcaccgggcagtggcatCgagtgtccaaagtgcgacac	9	6	14	12	3	1	0	1	0	0	0	3	2	2	0	2	3	1	3	2	3	1	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:77618162C>T	uc003yav.2	+	2	2226	c.1839C>T	c.(1837-1839)ATC>ATT	p.I613I	ZFHX4_uc003yat.1_Silent_p.I613I|ZFHX4_uc003yau.1_Silent_p.I613I|ZFHX4_uc003yaw.1_Silent_p.I613I	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	613	C2H2-type 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCAGTGGCATCGAGTGTCCAA	0.557										HNSCC(33;0.089)			6	80					0	0	0	0	T	77618162	T	T	77618162	2	4	210	1	0	0	0	0	0	0	0	1	17702	874	31	1		1	ZFHX4	8	77618162	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	39470133	77618162	68745860	69	38301											
KIAA1429	25962	broad.mit.edu	37	chr8	95547110	95547110	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggttgtggctggggaggTggtggcggtggaggtggtgg	2	11	25	3	1	0	0	0	0	0	0	0	2	0	2	0	12	0	2	0	12	0	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:95547110T>G	uc003ygo.1	-	5	454	c.441A>C	c.(439-441)CCA>CCC	p.P147P	KIAA1429_uc003ygp.2_Silent_p.P147P	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	147	Pro-rich.				mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GCTGGGGAggtggtggcggtg	0.323													5	31					0	0	0	0	G	95547110	G	G	95547110	2	3	210	1	0	0	0	0	0	0	0	1	8270	1683	59	5		5	KIAA1429	8	95547110	Silent	SNP	T	TCGA-CV-6955-01A-11D-2012-08	17928948	95547110	50816912	70	38302											
VPS13B	157680	broad.mit.edu	37	chr8	100832288	100832288	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgggacctctggctatttGaaggagagaaaattgttcta	13	12	11	5	0	2	2	0	1	2	1	2	5	2	4	1	3	0	2	1	3	6	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:100832288G>C	uc003yiv.2	+	49	9118	c.9007G>C	c.(9007-9009)GAA>CAA	p.E3003Q	VPS13B_uc003yiw.2_Missense_Mutation_p.E2978Q	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3003					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTGGCTATTTGAAGGAGAGAA	0.378													4	105					0	0	0	0	C	100832288	C	C	100832288	3	2	210	1	0	0	0	0	1	0	0	0	17258	1291	45	2	9391	2	VPS13B	8	100832288	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	5285178	100832288	45531734	71	38303											
RNF139	11236	broad.mit.edu	37	chr8	125498991	125498991	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	actgcagtcctgcattttatCcatggaatgacagaccctgt	10	12	8	11	0	0	2	0	1	0	1	2	3	2	3	3	1	2	2	3	1	2	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:125498991C>T	uc003yrc.2	+	2	1444	c.1101C>T	c.(1099-1101)ATC>ATT	p.I367I		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	367	Helical; (Potential).				negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TGCATTTTATCCATGGAATGA	0.423									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				19	202					0	0	0	0	T	125498991	T	T	125498991	2	4	210	1	0	0	0	0	0	0	0	1	13507	845	30	2		2	RNF139	8	125498991	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	24666703	125498991	20865031	72	38304											
BAI1	575	broad.mit.edu	37	chr8	143569790	143569790	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttccccatgaagggctggCgggccacgggtgactgggcc	5	6	17	13	2	0	2	0	2	0	0	1	2	1	2	4	5	0	2	4	5	1	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr8:143569790C>T	uc003ywm.2	+	13	2557	c.2374C>T	c.(2374-2376)CGG>TGG	p.R792W		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	792	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GAAGGGCTGGCGGGCCACGGG	0.632													5	119					0	0	0	0	T	143569790	T	T	143569790	3	4	210	1	0	0	0	0	1	0	0	0	1300	759	27	1	2424	1	BAI1	8	143569790	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	18070799	143569790	2794232	73	38305											
TESK1	7016	broad.mit.edu	37	chr9	35609464	35609464	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctggggagccctggaacCgggcccagcatagcctgccc	6	4	16	15	1	0	0	0	0	0	0	0	2	0	2	5	5	5	2	5	5	2	1	rs142237307	byFrequency	TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:35609464C>A	uc003zxa.2	+	10	1942	c.1606C>A	c.(1606-1608)CGG>AGG	p.R536R	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Silent_p.R376R	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	536					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCCCTGGAACCGGGCCCAGCA	0.687													18	28					1.67942e-08	1.92822e-08	1	0	A	35609464	A	A	35609464	2	1	210	1	0	0	0	0	0	0	0	1	15833	643	23	3		3	TESK1	9	35609464	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08		35609464	105603967	74	38306											
TRPM3	80036	broad.mit.edu	37	chr9	73164531	73164531	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttttctctgaagtattcttCtatgcattgctcttcaaagt	8	19	5	9	0	5	1	1	1	4	0	6	1	5	1	0	0	2	3	0	0	4	8			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:73164531C>G	uc004aid.2	-	24	3842	c.3598G>C	c.(3598-3600)GAA>CAA	p.E1200Q	TRPM3_uc004ahu.2_Missense_Mutation_p.E1042Q|TRPM3_uc004ahv.2_Missense_Mutation_p.E1002Q|TRPM3_uc004ahw.2_Missense_Mutation_p.E1072Q|TRPM3_uc004ahx.2_Missense_Mutation_p.E1059Q|TRPM3_uc004ahy.2_Missense_Mutation_p.E1062Q|TRPM3_uc004ahz.2_Missense_Mutation_p.E1049Q|TRPM3_uc004aia.2_Missense_Mutation_p.E1047Q|TRPM3_uc004aib.2_Missense_Mutation_p.E1037Q|TRPM3_uc004aic.2_Missense_Mutation_p.E1200Q	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1225	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AAGTATTCTTCTATGCATTGC	0.413													3	71					0	0	0	0	G	73164531	G	G	73164531	3	3	210	1	0	0	0	0	1	0	0	0	16654	922	32	2	1533	2	TRPM3	9	73164531	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	37555067	73164531	68048900	75	38307											
SURF1	6834	broad.mit.edu	37	chr9	136220669	136220669	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgagttgaggaggagatgagGccgccctcccgggcctcccg	6	6	16	13	3	0	4	0	3	0	1	2	6	2	5	5	4	0	1	5	4	0	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:136220669G>A	uc004cdh.1	-	5	482	c.450C>T	c.(448-450)GGC>GGT	p.G150G	SURF1_uc004cdg.1_Silent_p.G41G|SURF2_uc004cdi.2_5'Flank	NM_003172	NP_003163	Q15526	SURF1_HUMAN	surfeit 1	150					aerobic respiration|respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			breast(2)	2				OV - Ovarian serous cystadenocarcinoma(145;5.06e-07)|Epithelial(140;4.25e-06)|all cancers(34;3.93e-05)		AGGAGATGAGGCCGCCCTCCC	0.617													8	176					0	0	0	0	A	136220669	A	A	136220669	2	1	210	1	0	0	0	0	0	0	0	1	15469	1190	42	4		4	SURF1	9	136220669	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	63056138	136220669	4992762	76	38308											
NOTCH1	4851	broad.mit.edu	37	chr9	139399790	139399790	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttccgcacgctggcagtCaaagccgtcgaagaggcagc	9	5	13	14	4	1	1	1	0	0	1	3	2	2	1	3	2	2	4	3	2	2	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:139399790C>G	uc004chz.2	-	25	4558	c.4558G>C	c.(4558-4560)GAC>CAC	p.D1520H	NOTCH1_uc004cia.1_Missense_Mutation_p.D750H	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1520	Extracellular (Potential).|LNR 2.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGCTGGCAGTCAAAGCCGTCG	0.627			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			2	6					0	0	0	0	G	139399790	G	G	139399790	3	3	210	1	0	0	0	0	1	0	0	0	10601	826	29	2	3149	2	NOTCH1	9	139399790	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	3179121	139399790	1813641	77	38309											
NOTCH1	4851	broad.mit.edu	37	chr9	139412284	139412284	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgggttcgagacgcactcgTtgacgtcgatctcgcatcgg	7	9	13	12	8	1	2	0	1	1	1	6	4	1	2	0	2	0	4	0	2	0	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:139412284T>G	uc004chz.2	-	8	1361	c.1361A>C	c.(1360-1362)AAC>ACC	p.N454T		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	454	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GACGCACTCGTTGACGTCGAT	0.657			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			11	84					0	0	0	0	G	139412284	G	G	139412284	3	3	210	1	0	0	0	0	1	0	0	0	10601	1725	60	5	6414	5	NOTCH1	9	139412284	Missense_Mutation	SNP	T	TCGA-CV-6955-01A-11D-2012-08	12494	139412284	1801147	78	38310											
NOTCH1	4851	broad.mit.edu	37	chr9	139418203	139418204	+	Frame_Shift_Ins	INS	-	T	T																															ggcagcggcacttgtactccINSgtcagcgtgagcaggtcgca																										TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:139418203_139418204insT	uc004chz.2	-	3	368_369	c.368_369insA	c.(367-369)ACGfs	p.T123fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	123	Extracellular (Potential).|EGF-like 3.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACTTGTACTCCGTCAGCGTGAG	0.708			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								T	139418204	T	T	139418203	7	5	210	1	0	1	1	0	0	0	0	0	10601	639	23	0	7426	0	NOTCH1	9	139418203	Frame_Shift_Ins	INS	-	TCGA-CV-6955-01A-11D-2012-08	5919	139418203	1795228	79	38311											
CACNA1B	774	broad.mit.edu	37	chr9	140991032	140991032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accacttggatgagttcatcCgggtctgggctgaatacgac	9	10	12	10	2	2	2	1	2	1	0	3	4	3	3	2	3	1	2	2	3	2	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr9:140991032C>T	uc004cog.2	+	36	5336	c.5191C>T	c.(5191-5193)CGG>TGG	p.R1731W	CACNA1B_uc004coi.2_Missense_Mutation_p.R943W|CACNA1B_uc004cok.1_RNA|CACNA1B_uc010ncp.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1731	EF-hand.|Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGAGTTCATCCGGGTCTGGGC	0.562													37	47					0	0	0	0	T	140991032	T	T	140991032	3	4	210	1	0	0	0	0	1	0	0	0	2551	643	23	1	5333	1	CACNA1B	9	140991032	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	1572829	140991032	222399	80	38312											
SEC61A2	55176	broad.mit.edu	37	chr10	12197794	12197794	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttgtttgttgctggtttGattgtgctgctgttagatga	5	19	13	4	0	0	3	0	2	0	1	0	3	0	3	0	1	3	8	0	1	1	6			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:12197794G>A	uc001ile.2	+	7	627	c.480G>A	c.(478-480)TTG>TTA	p.L160L	SEC61A2_uc010qbq.1_Silent_p.L138L|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Silent_p.L160L	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	160	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				TTGCTGGTTTGATTGTGCTGC	0.473													34	303					0	0	0	0	A	12197794	A	A	12197794	2	1	210	1	0	0	0	0	0	0	0	1	14066	1281	45	2		2	SEC61A2	10	12197794	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08		12197794	123336953	81	38313											
ACBD5	91452	broad.mit.edu	37	chr10	27512312	27512312	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actctttttgtcctcgacaaTttcataaaatggacctatga	12	15	5	9	1	2	1	1	1	1	0	4	3	3	2	2	1	0	0	2	1	4	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:27512312T>A	uc010qdp.1	-	5	636	c.445A>T	c.(445-447)ATT>TTT	p.I149F	ACBD5_uc010qdm.1_Missense_Mutation_p.I147F|ACBD5_uc010qdn.1_Missense_Mutation_p.I40F|ACBD5_uc010qdo.1_Missense_Mutation_p.I40F|ACBD5_uc001ito.2_Missense_Mutation_p.I114F|ACBD5_uc001itp.2_Missense_Mutation_p.I40F|ACBD5_uc001itq.2_Missense_Mutation_p.I40F|ACBD5_uc001itr.1_5'UTR	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	147					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						TCCTCGACAATTTCATAAAAT	0.318													3	51					0	0	0	0	A	27512312	A	A	27512312	3	1	210	1	0	0	0	0	1	0	0	0	125	1493	52	5	1168	5	ACBD5	10	27512312	Missense_Mutation	SNP	T	TCGA-CV-6955-01A-11D-2012-08	15314518	27512312	108022435	82	38314											
IFIT2	3433	broad.mit.edu	37	chr10	91066451	91066451	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttggagaaagccccaggtgtAacagatgttcttcgcagtgc	10	10	12	9	1	1	2	0	0	1	2	2	3	1	2	2	2	3	3	2	2	2	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:91066451A>T	uc009xts.2	+	2	913	c.738A>T	c.(736-738)GTA>GTT	p.V246V	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	246					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				CCCCAGGTGTAACAGATGTTC	0.438													19	54					0	0	0	0	T	91066451	T	T	91066451	2	4	210	1	0	0	0	0	0	0	0	1	7562	349	13	5		5	IFIT2	10	91066451	Silent	SNP	A	TCGA-CV-6955-01A-11D-2012-08	63554139	91066451	44468296	83	38315											
TACC2	10579	broad.mit.edu	37	chr10	123970684	123970684	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaggggaggtaaccccatcGgatagcggggggcaagagga	11	3	19	8	2	0	1	0	0	0	1	1	4	0	4	2	8	2	3	2	8	3	2	rs35532970		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:123970684G>A	uc001lfv.2	+	9	7104	c.6744G>A	c.(6742-6744)TCG>TCA	p.S2248S	TACC2_uc001lfw.2_Silent_p.S394S|TACC2_uc009xzx.2_Silent_p.S2203S|TACC2_uc010qtv.1_Silent_p.S2252S|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Silent_p.S326S|TACC2_uc001lga.2_Silent_p.S326S|TACC2_uc009xzy.2_Silent_p.S326S|TACC2_uc001lgb.2_Silent_p.S283S|TACC2_uc010qtw.1_Silent_p.S343S	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2248						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TAACCCCATCGGATAGCGGGG	0.602													5	55					0	0	0	0	A	123970684	A	A	123970684	2	1	210	1	0	0	0	0	0	0	0	1	15568	1103	39	1		1	TACC2	10	123970684	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	32904233	123970684	11564063	84	38316											
CUZD1	50624	broad.mit.edu	37	chr10	124598737	124598737	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcactttcacagcttccatCtggatcaagcctgtggaaaa	11	12	7	11	0	4	0	3	0	1	0	5	2	5	2	2	2	2	1	2	2	3	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr10:124598737C>T	uc001lgq.2	-	3	576	c.244G>A	c.(244-246)GAT>AAT	p.D82N	CUZD1_uc001lgp.2_5'Flank|CUZD1_uc009yad.2_5'Flank|CUZD1_uc009yaf.2_Intron|CUZD1_uc001lgr.2_5'UTR|CUZD1_uc010qty.1_5'UTR|CUZD1_uc009yae.2_5'UTR|CUZD1_uc001lgs.2_Missense_Mutation_p.D82N|CUZD1_uc010qtz.1_Missense_Mutation_p.D82N	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor	82	CUB 1.|Extracellular (Potential).				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		CAGCTTCCATCTGGATCAAGC	0.453													7	107					0	0	0	0	T	124598737	T	T	124598737	3	4	210	1	0	0	0	0	1	0	0	0	4083	913	32	2	1607	2	CUZD1	10	124598737	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	628053	124598737	10936010	85	38317											
NLRP6	171389	broad.mit.edu	37	chr11	281225	281225	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagaggtcacctaccagttCatcgaccagagcttccagga	12	7	9	13	1	2	2	2	0	0	2	4	4	3	3	4	2	2	2	4	2	1	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr11:281225C>G	uc010qvs.1	+	4	1491	c.1491C>G	c.(1489-1491)TTC>TTG	p.F497L	NLRP6_uc010qvt.1_Missense_Mutation_p.F497L	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	497	NACHT.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCTACCAGTTCATCGACCAGA	0.627													5	122					0	0	0	0	G	281225	G	G	281225	3	3	210	1	0	0	0	0	1	0	0	0	10535	825	29	2	1505	2	NLRP6	11	281225	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08		281225	134725291	86	38318											
NUP98	4928	broad.mit.edu	37	chr11	3727721	3727721	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaagatgcaatatgtgttGaggcagacacaggttcctga	12	10	13	6	0	0	5	0	3	0	2	1	5	1	5	1	2	1	4	1	2	3	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr11:3727721G>C	uc001lyh.2	-	21	3170	c.2879C>G	c.(2878-2880)TCA>TGA	p.S960*	NUP98_uc001lyi.2_Nonsense_Mutation_p.S960*|NUP98_uc001lyg.2_Nonsense_Mutation_p.S28*	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	977					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AATATGTGTTGAGGCAGACAC	0.423			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								4	127					0	0	0	0	C	3727721	C	C	3727721	4	2	210	1	0	0	0	0	0	1	0	0	10827	1294	45	2	2575	2	NUP98	11	3727721	Nonsense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	3446496	3727721	131278795	87	38319											
PSMA1	5682	broad.mit.edu	37	chr11	14540580	14540580	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgacatcattgtcatactgaTttcgaaactaaaagtaaaag	17	12	6	6	1	2	2	2	2	0	0	3	3	2	2	0	0	2	1	0	0	6	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr11:14540580T>C	uc001mlk.2	-	2	157	c.11A>G	c.(10-12)AAT>AGT	p.N4S	PSMA1_uc001mll.2_Missense_Mutation_p.N10S|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_5'UTR|PSMA1_uc010rcq.1_Missense_Mutation_p.N4S	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	4					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						GTCATACTGATTTCGAAACTA	0.308													10	37					0	0	0	0	C	14540580	C	C	14540580	3	2	210	1	0	0	0	0	1	0	0	0	12728	1493	52	5	866	5	PSMA1	11	14540580	Missense_Mutation	SNP	T	TCGA-CV-6955-01A-11D-2012-08	10812859	14540580	120465936	88	38320											
LDHC	3948	broad.mit.edu	37	chr11	18467778	18467778	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctatgaaattatcaagctGaaggggtatacctcttgggc	11	11	11	8	0	2	2	1	2	1	0	2	2	2	2	2	3	2	2	2	3	7	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr11:18467778G>A	uc001mon.3	+	7	844	c.732G>A	c.(730-732)CTG>CTA	p.L244L	LDHC_uc001mom.3_Silent_p.L244L|LDHC_uc009yhp.2_Intron|LDHC_uc001moo.3_Silent_p.L128L|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_Intron	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	244					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	TTATCAAGCTGAAGGGGTATA	0.373													6	78					0	0	0	0	A	18467778	A	A	18467778	2	1	210	1	0	0	0	0	0	0	0	1	8742	1277	45	2		2	LDHC	11	18467778	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	3927198	18467778	116538738	89	38321											
ARHGAP20	57569	broad.mit.edu	37	chr11	110451310	110451310	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggaaaagtttcacgtgatttCcttcactaccagacaagctt	12	12	7	10	1	2	2	2	1	0	1	3	3	3	3	2	1	2	2	2	1	4	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr11:110451310C>G	uc001pkz.1	-	16	2645	c.2360G>C	c.(2359-2361)GGA>GCA	p.G787A	ARHGAP20_uc001pky.1_Missense_Mutation_p.G764A|ARHGAP20_uc009yyb.1_Missense_Mutation_p.G751A|ARHGAP20_uc001pla.1_Missense_Mutation_p.G751A|ARHGAP20_uc001plb.2_Missense_Mutation_p.G330A	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	787					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		CACGTGATTTCCTTCACTACC	0.413													5	97					0	0	0	0	G	110451310	G	G	110451310	3	3	210	1	0	0	0	0	1	0	0	0	870	855	30	2	1219	2	ARHGAP20	11	110451310	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	91983532	110451310	24555206	90	38322											
KCNJ8	3764	broad.mit.edu	37	chr12	21919137	21919137	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaatcacgtggcagatgatCaaaggggccaccagaaaaat	16	6	10	9	1	3	3	3	1	0	2	3	3	3	3	2	3	0	1	2	3	4	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:21919137C>G	uc001rff.2	-	3	1133	c.795G>C	c.(793-795)TTG>TTC	p.L265F		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	265	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	GGCAGATGATCAAAGGGGCCA	0.478													15	34					0	0	0	0	G	21919137	G	G	21919137	3	3	210	1	0	0	0	0	1	0	0	0	8095	825	29	2	483	2	KCNJ8	12	21919137	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08		21919137	111932758	91	38323											
FAR2	55711	broad.mit.edu	37	chr12	29486610	29486610	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatactgccctcttccttatCgcctggcgccttctcattgc	5	14	6	16	2	2	0	1	0	2	0	5	0	3	0	4	1	3	0	4	1	3	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:29486610C>T	uc001ris.3	+	12	1578	c.1431C>T	c.(1429-1431)ATC>ATT	p.I477I	FAR2_uc001rit.2_Silent_p.I477I|FAR2_uc009zjm.2_Silent_p.I380I	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	477	Helical; (Potential).				ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						TCTTCCTTATCGCCTGGCGCC	0.428													12	185					0	0	0	0	T	29486610	T	T	29486610	2	4	210	1	0	0	0	0	0	0	0	1	5707	874	31	1		1	FAR2	12	29486610	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	7567473	29486610	104365285	92	38324											
SOAT2	8435	broad.mit.edu	37	chr12	53509201	53509201	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggagtttgacctactgatCttcagcttcggacagctgcc	7	12	10	12	1	2	2	1	2	1	0	3	4	2	4	2	2	4	3	2	2	1	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:53509201C>T	uc001sbv.2	+	6	559	c.471C>T	c.(469-471)ATC>ATT	p.I157I	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	157	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						ACCTACTGATCTTCAGCTTCG	0.552													3	42					0	0	0	0	T	53509201	T	T	53509201	2	4	210	1	0	0	0	0	0	0	0	1	14975	903	32	2		2	SOAT2	12	53509201	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	24022591	53509201	80342694	93	38325											
METTL7B	196410	broad.mit.edu	37	chr12	56075775	56075775	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccctactggagctgggctgCggaaccggagccaactttca	8	7	13	13	2	1	0	1	0	0	0	1	3	1	3	3	4	6	2	3	4	3	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:56075775C>T	uc010spr.1	+	1	446	c.237C>T	c.(235-237)TGC>TGT	p.C79C		NM_152637	NP_689850	Q6UX53	MET7B_HUMAN	methyltransferase like 7B precursor	79							methyltransferase activity				0						AGCTGGGCTGCGGAACCGGAG	0.572													9	29					0	0	0	0	T	56075775	T	T	56075775	2	4	210	1	0	0	0	0	0	0	0	1	9559	776	27	1		1	METTL7B	12	56075775	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	2566574	56075775	77776120	94	38326											
ACACB	32	broad.mit.edu	37	chr12	109684111	109684111	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccctggagaggaccttctgtAcctgcgggcatccgagatgg	7	8	14	12	2	1	2	0	0	1	2	2	5	2	3	4	4	2	2	4	4	1	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:109684111A>G	uc001tob.2	+	39	5548	c.5429A>G	c.(5428-5430)TAC>TGC	p.Y1810C	ACACB_uc001toc.2_Missense_Mutation_p.Y1810C|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.Y476C	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1810	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GACCTTCTGTACCTGCGGGCA	0.562													4	107					0	0	0	0	G	109684111	G	G	109684111	3	3	210	1	0	0	0	0	1	0	0	0	107	391	14	5	5579	5	ACACB	12	109684111	Missense_Mutation	SNP	A	TCGA-CV-6955-01A-11D-2012-08	53608336	109684111	24167784	95	38327											
CIT	11113	broad.mit.edu	37	chr12	120166409	120166409	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttcttctccaggtcattGagctagacatttggaaagat	10	14	9	8	0	3	3	1	1	2	2	4	4	3	4	1	2	2	2	1	2	2	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr12:120166409G>C	uc001txi.1	-	27	3416	c.3363C>G	c.(3361-3363)CTC>CTG	p.L1121L	CIT_uc001txh.1_Silent_p.L655L|CIT_uc001txj.1_Silent_p.L1163L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1121	Potential.|Interaction with Rho/Rac.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CCAGGTCATTGAGCTAGACAT	0.438													7	143					0	0	0	0	C	120166409	C	C	120166409	2	2	210	1	0	0	0	0	0	0	0	1	3453	1277	45	2		2	CIT	12	120166409	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	10482298	120166409	13685486	96	38328											
LNX2	222484	broad.mit.edu	37	chr13	28136648	28136648	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttagcctgccgtcctgggCagccaaccccccttccaaca	7	7	8	19	1	0	0	0	0	0	0	2	0	2	0	8	1	5	2	8	1	3	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr13:28136648C>A	uc001url.3	-	5	1435	c.1126G>T	c.(1126-1128)GCC>TCC	p.A376S	LNX2_uc001urm.1_Missense_Mutation_p.A376S	NM_153371	NP_699202	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	376	PDZ 2.						zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	6		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CCGTCCTGGGCAGCCAACCCC	0.532													20	150					1.1804e-14	1.38084e-14	1	0	A	28136648	A	A	28136648	3	1	210	1	0	0	0	0	1	0	0	0	8908	710	25	4	970	4	LNX2	13	28136648	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08		28136648	87033230	97	38329											
FLT3	2322	broad.mit.edu	37	chr13	28609671	28609671	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtctcacaagatgtgccaaGggaattgtatgcacagcact	12	9	10	10	1	1	1	1	0	1	1	2	2	1	2	1	1	3	3	1	1	4	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr13:28609671G>C	uc001urw.2	-	12	1640	c.1558C>G	c.(1558-1560)CTT>GTT	p.L520V	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.L520V	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	520	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GATGTGCCAAGGGAATTGTAT	0.453			Mis|O		AML|ALL								5	84					0	0	0	0	C	28609671	C	C	28609671	3	2	210	1	0	0	0	0	1	0	0	0	5974	1000	35	4	1475	4	FLT3	13	28609671	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	473023	28609671	86560207	98	38330											
ZC3H13	23091	broad.mit.edu	37	chr13	46559752	46559752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggagtctcttagttcccttCggtccctagtatctctggca	5	15	9	12	1	2	0	0	0	2	0	7	1	4	1	2	3	0	3	2	3	3	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr13:46559752C>T	uc010tfw.1	-	9	1406	c.1400G>A	c.(1399-1401)CGA>CAA	p.R467Q	ZC3H13_uc001vas.1_Missense_Mutation_p.R467Q|ZC3H13_uc001vat.1_Missense_Mutation_p.R467Q	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	467	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TAGTTCCCTTCGGTCCCTAGT	0.507													12	181					0	0	0	0	T	46559752	T	T	46559752	3	4	210	1	0	0	0	0	1	0	0	0	17632	884	31	1	3326	1	ZC3H13	13	46559752	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	17950081	46559752	68610126	99	38331											
NEK5	341676	broad.mit.edu	37	chr13	52660423	52660423	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaatttacctctggttctCtccccatcttctttctaatt	7	19	3	12	0	5	1	0	1	5	0	7	1	6	1	3	1	1	1	3	1	3	7			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr13:52660423C>A	uc001vge.2	-	16	1609	c.1469G>T	c.(1468-1470)AGA>ATA	p.R490I		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	490							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CTCTGGTTCTCTCCCCATCTT	0.363													13	42					0.000151284	0.000165523	1	0	A	52660423	A	A	52660423	3	1	210	1	0	0	0	0	1	0	0	0	10381	913	32	2	685	2	NEK5	13	52660423	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	6100671	52660423	62509455	100	38332											
CHD8	57680	broad.mit.edu	37	chr14	21870656	21870656	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccaattcgatgacatcgtgCctgggcctggtttaaaataa	11	11	9	10	2	0	1	0	1	0	0	2	2	0	1	3	2	1	1	3	2	4	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:21870656C>T	uc001was.1	-	19	2978	c.2884G>A	c.(2884-2886)GCA>ACA	p.A962T	CHD8_uc001war.1_Missense_Mutation_p.A858T|CHD8_uc001wav.1_Missense_Mutation_p.A404T	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1241	Helicase C-terminal.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TGACATCGTGCCTGGGCCTGG	0.413													17	26					0	0	0	0	T	21870656	T	T	21870656	3	4	210	1	0	0	0	0	1	0	0	0	3346	739	26	4	4104	4	CHD8	14	21870656	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08		21870656	85478884	101	38333											
COCH	1690	broad.mit.edu	37	chr14	31358870	31358870	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgggcacctctggatgaccTgaaagatatggcttctaaac	11	11	10	9	0	2	3	0	2	2	1	2	4	2	4	2	3	1	2	2	3	4	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:31358870T>G	uc001wqr.2	+	12	1606	c.1526T>G	c.(1525-1527)CTG>CGG	p.L509R	COCH_uc001wqp.2_Missense_Mutation_p.L509R|COCH_uc001wqq.3_Intron|uc001wqs.2_RNA|COCH_uc001wqt.1_Missense_Mutation_p.L360R	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	509	VWFA 2.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		CTGGATGACCTGAAAGATATG	0.388													7	39					0	0	0	0	G	31358870	G	G	31358870	3	3	210	1	0	0	0	0	1	0	0	0	3671	1580	55	5	1568	5	COCH	14	31358870	Missense_Mutation	SNP	T	TCGA-CV-6955-01A-11D-2012-08	9488214	31358870	75990670	102	38334											
FSCB	84075	broad.mit.edu	37	chr14	44975153	44975153	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcagaatttcagccagAagctctacagaaggagactc	14	6	12	9	0	2	4	1	0	1	4	3	6	2	5	1	3	3	2	1	3	4	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:44975153A>T	uc001wvn.2	-	1	1347	c.1038T>A	c.(1036-1038)CTT>CTA	p.L346L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	346	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TTTCAGCCAGAAGCTCTACAG	0.507													13	111					0	0	0	0	T	44975153	T	T	44975153	2	4	210	1	0	0	0	0	0	0	0	1	6100	233	9	5		5	FSCB	14	44975153	Silent	SNP	A	TCGA-CV-6955-01A-11D-2012-08	13616283	44975153	62374387	103	38335											
SLC39A9	55334	broad.mit.edu	37	chr14	69890883	69890883	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctggcagtcatcgtgcctGaaggagtacatgccctttat	8	12	10	11	1	2	1	1	1	1	0	3	2	2	2	2	2	3	2	2	2	3	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:69890883G>A	uc001xle.2	+	2	849	c.169G>A	c.(169-171)GAA>AAA	p.E57K	SLC39A9_uc001xld.3_RNA|SLC39A9_uc010aqx.2_Missense_Mutation_p.E57K|SLC39A9_uc001xlf.3_Missense_Mutation_p.E57K|SLC39A9_uc001xlg.3_RNA	NM_018375	NP_060845	Q9NUM3	S39A9_HUMAN	solute carrier family 39 (zinc transporter),	57					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		CATCGTGCCTGAAGGAGTACA	0.458													8	37					0	0	0	0	A	69890883	A	A	69890883	3	1	210	1	0	0	0	0	1	0	0	0	14689	1291	45	2	175	2	SLC39A9	14	69890883	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	24915730	69890883	37458657	104	38336											
KIAA1409	57578	broad.mit.edu	37	chr14	94060062	94060062	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatccgagttctctcagctGtcttccctggcagtccctct	6	13	7	15	1	4	0	1	0	3	0	8	1	7	0	3	1	1	3	3	1	1	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:94060062G>A	uc001ybv.1	+	20	2621	c.2538G>A	c.(2536-2538)CTG>CTA	p.L846L	KIAA1409_uc001ybs.1_Silent_p.L846L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1023						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TCTCTCAGCTGTCTTCCCTGG	0.473													27	108					0	0	0	0	A	94060062	A	A	94060062	2	1	210	1	0	0	0	0	0	0	0	1	8269	1364	48	4		4	KIAA1409	14	94060062	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	24169179	94060062	13289478	105	38337											
AHNAK2	113146	broad.mit.edu	37	chr14	105411954	105411954	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacttggctcctggggcctcGacgtccacctccatgctggg	5	9	12	15	2	0	0	0	0	0	0	4	1	3	0	5	4	2	2	5	4	1	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr14:105411954G>A	uc010axc.1	-	7	9954	c.9834C>T	c.(9832-9834)GTC>GTT	p.V3278V	AHNAK2_uc001ypx.2_Silent_p.V3178V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3278						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGGGGCCTCGACGTCCACCT	0.607													30	234					0	0	0	0	A	105411954	A	A	105411954	2	1	210	1	0	0	0	0	0	0	0	1	415	1045	37	1		1	AHNAK2	14	105411954	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	11351892	105411954	1937586	106	38338											
THBS1	7057	broad.mit.edu	37	chr15	39881288	39881288	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agtgcacagatgttgatgagGtgaggaactgatggggctcc	10	9	16	6	0	0	5	0	4	0	1	1	6	1	6	1	4	2	3	1	4	1	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr15:39881288G>A	uc001zkh.2	+	11	1952	c.1773_splice	c.e11+1	p.E591_splice	THBS1_uc010bbi.2_Splice_Site_p.E63_splice	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor						activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TGTTGATGAGGTGAGGAACTG	0.517													6	136					0	0	0	0	A	39881288	A	A	39881288	5	1	210	1	0	0	0	0	0	0	1	0	15919	1275	44	4	1812	4	THBS1	15	39881288	Splice_Site	SNP	G	TCGA-CV-6955-01A-11D-2012-08		39881288	62650104	107	38339											
MGA	23269	broad.mit.edu	37	chr15	42059359	42059359	+	Frame_Shift_Del	DEL	A	-	-																															aagttgggtcagttggacacAaaatgaacttaacagggaat																										TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr15:42059359delA	uc010ucy.1	+	24	9260	c.9079delA	c.(9079-9081)AAAfs	p.K3027fs	MGA_uc010ucz.1_Frame_Shift_Del_p.K2818fs	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2988						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AGTTGGACACAAAATGAACTT	0.493													---	---	---								-	42059359	-	-	42059359	7	5	210	1	0	1	0	1	0	0	0	0	9593	131	5	0	9169	0	MGA	15	42059359	Frame_Shift_Del	DEL	A	TCGA-CV-6955-01A-11D-2012-08	2178071	42059359	60472033	108	38340											
ZSCAN2	54993	broad.mit.edu	37	chr15	85163919	85163919	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatattctcggaaatgcctGaaggtgaaagtgctcagcac	13	9	11	8	1	2	3	1	2	1	1	3	4	2	4	1	2	3	2	1	2	4	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr15:85163919G>C	uc002bkr.2	+	3	719	c.493G>C	c.(493-495)GAA>CAA	p.E165Q	ZSCAN2_uc010bmz.1_Missense_Mutation_p.E163Q|ZSCAN2_uc010bna.2_Missense_Mutation_p.E15Q|ZSCAN2_uc010uox.1_Missense_Mutation_p.E164Q|ZSCAN2_uc010uoy.1_Missense_Mutation_p.E164Q|ZSCAN2_uc010uoz.1_Missense_Mutation_p.E164Q	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	165					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		GGAAATGCCTGAAGGTGAAAG	0.473													6	119					0	0	0	0	C	85163919	C	C	85163919	3	2	210	1	0	0	0	0	1	0	0	0	18298	1291	45	2	589	2	ZSCAN2	15	85163919	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	43104560	85163919	17367473	109	38341											
IQGAP1	8826	broad.mit.edu	37	chr15	91020962	91020962	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggttattaaaatggttgtaaGtttcaaccgtggtgcccgtg	9	14	12	6	2	1	0	1	0	0	0	1	0	1	0	2	3	2	4	2	3	5	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr15:91020962G>C	uc002bpl.1	+	26	3271	c.3170G>C	c.(3169-3171)AGT>ACT	p.S1057T		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1057	Ras-GAP.|C1.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			ATGGTTGTAAGTTTCAACCGT	0.408													5	55					0	0	0	0	C	91020962	C	C	91020962	3	2	210	1	0	0	0	0	1	0	0	0	7853	1029	36	4	3272	4	IQGAP1	15	91020962	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	5857043	91020962	11510430	110	38342											
ARRDC4	91947	broad.mit.edu	37	chr15	98512388	98512388	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctatgcagaaatagaaaatTgttcctctcgtctgattgtt	11	16	7	7	1	3	3	0	1	3	2	5	3	4	3	1	0	1	3	1	0	5	6			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr15:98512388T>C	uc010bom.2	+	5	820	c.661T>C	c.(661-663)TGT>CGT	p.C221R	ARRDC4_uc002bui.3_Missense_Mutation_p.C134R	NM_183376	NP_899232	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	221					signal transduction						0	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			AATAGAAAATTGTTCCTCTCG	0.393													15	43					0	0	0	0	C	98512388	C	C	98512388	3	2	210	1	0	0	0	0	1	0	0	0	987	1812	63	5	679	5	ARRDC4	15	98512388	Missense_Mutation	SNP	T	TCGA-CV-6955-01A-11D-2012-08	7491426	98512388	4019004	111	38343											
NDUFB10	4716	broad.mit.edu	37	chr16	2011519	2011519	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagtcgaccaagaaattatCaacattatgcaggatcggct	16	9	8	8	2	1	1	1	0	0	1	3	3	1	2	1	2	2	2	1	2	6	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:2011519C>G	uc002cni.2	+	3	400	c.291C>G	c.(289-291)ATC>ATG	p.I97M	NDUFB10_uc002cnj.2_Missense_Mutation_p.I97M	NM_004548	NP_004539	O96000	NDUBA_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	97					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	AAGAAATTATCAACATTATGC	0.473													6	192					0	0	0	0	G	2011519	G	G	2011519	3	3	210	1	0	0	0	0	1	0	0	0	10333	816	29	2	301	2	NDUFB10	16	2011519	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08		2011519	88343234	112	38344											
C16orf45	89927	broad.mit.edu	37	chr16	15677026	15677026	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcacagggagcaagaagaaGacaaggaaatggctgatttc	16	7	12	6	0	1	4	1	1	0	3	2	6	1	6	0	3	1	2	0	3	5	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:15677026G>A	uc002ddo.2	+	5	619	c.433G>A	c.(433-435)GAC>AAC	p.D145N	C16orf45_uc002ddp.2_Missense_Mutation_p.D128N	NM_033201	NP_149978	Q96MC5	CP045_HUMAN	hypothetical protein LOC89927 isoform 1	145										ovary(1)	1						GCAAGAAGAAGACAAGGAAAT	0.388													17	104					0	0	0	0	A	15677026	A	A	15677026	3	1	210	1	0	0	0	0	1	0	0	0	1820	942	33	2	510	2	C16orf45	16	15677026	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	13665507	15677026	74677727	113	38345											
RBBP6	5930	broad.mit.edu	37	chr16	24552017	24552017	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacctttgatgggctccacAtctccctctgcgacttaaag	8	12	7	14	1	3	1	1	1	2	0	5	2	4	1	3	1	1	1	3	1	2	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:24552017A>G	uc002dmh.2	+	1	1110	c.70A>G	c.(70-72)ATC>GTC	p.I24V	RBBP6_uc010vcb.1_Intron|RBBP6_uc002dmg.2_Missense_Mutation_p.I24V|RBBP6_uc002dmi.2_Missense_Mutation_p.I24V|RBBP6_uc010bxr.2_Missense_Mutation_p.I24V	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	24	DWNN.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TGGGCTCCACATCTCCCTCTG	0.483													14	59					0	0	0	0	G	24552017	G	G	24552017	3	3	210	1	0	0	0	0	1	0	0	0	13168	217	8	5	72	5	RBBP6	16	24552017	Missense_Mutation	SNP	A	TCGA-CV-6955-01A-11D-2012-08	8874991	24552017	65802736	114	38346											
ZNF48	197407	broad.mit.edu	37	chr16	30410135	30410135	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcggccacataacccacctGgcccagtacccatggcccct	8	6	8	19	1	0	0	0	0	0	0	0	0	0	0	7	3	3	1	7	3	2	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:30410135G>T	uc002dya.1	+	2	1623	c.1564G>T	c.(1564-1566)GGC>TGC	p.G522C	ZNF48_uc002dxz.1_Missense_Mutation_p.G399C	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	522	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAACCCACCTGGCCCAGTACC	0.677													5	110					0.00116845	0.00124903	1	0	T	30410135	T	T	30410135	3	4	210	1	0	0	0	0	1	0	0	0	18001	1348	47	4	1570	4	ZNF48	16	30410135	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	5858118	30410135	59944618	115	38347											
NLRC5	84166	broad.mit.edu	37	chr16	57101666	57101666	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcttgtctcaggttaacctCtgtgaggacgatgatgccag	9	11	12	9	1	2	2	1	2	2	0	3	4	2	3	2	2	3	2	2	2	1	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:57101666C>T	uc002ekk.1	+	36	4650	c.4425C>T	c.(4423-4425)CTC>CTT	p.L1475L	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_Silent_p.L17L|NLRC5_uc002ekr.1_Silent_p.L362L	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1475	LRR 15.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				AGGTTAACCTCTGTGAGGACG	0.507													5	79					0	0	0	0	T	57101666	T	T	57101666	2	4	210	1	0	0	0	0	0	0	0	1	10524	900	32	2		2	NLRC5	16	57101666	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	26691531	57101666	33253087	116	38348											
EDC4	23644	broad.mit.edu	37	chr16	67913808	67913808	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcagcagcagcagcagtaGcagcagctcccttacagctg	11	5	11	14	0	0	0	0	0	0	0	1	0	1	0	1	0	10	10	1	0	2	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:67913808G>T	uc002eur.2	+	16	2043	c.1877G>T	c.(1876-1878)AGC>ATC	p.S626I	EDC4_uc010cer.2_Missense_Mutation_p.S245I|EDC4_uc010vkg.1_Missense_Mutation_p.S558I|EDC4_uc002eus.2_Missense_Mutation_p.S356I|EDC4_uc002eut.1_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	626	Ser-rich.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		agcagcagtagcagcagcTCC	0.448													20	49					5.35267e-07	6.07071e-07	1	0	T	67913808	T	T	67913808	3	4	210	1	0	0	0	0	1	0	0	0	4930	971	34	4	1939	4	EDC4	16	67913808	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	10812142	67913808	22440945	117	38349											
HYDIN	54768	broad.mit.edu	37	chr16	70867859	70867859	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgtctgatacaccacgggtCcaaagggaatatgttcctgg	10	9	12	10	2	1	1	0	1	1	0	3	2	3	2	3	3	1	1	3	3	4	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr16:70867859C>A	uc002ezr.2	-	79	13735	c.13607G>T	c.(13606-13608)GGA>GTA	p.G4536V	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4537										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CACCACGGGTCCAAAGGGAAT	0.587													7	11					2.17888e-05	2.39805e-05	1	0	A	70867859	A	A	70867859	3	1	210	1	0	0	0	0	1	0	0	0	7506	855	30	2	1787	2	HYDIN	16	70867859	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	2954051	70867859	19486894	118	38350											
MYO1C	4641	broad.mit.edu	37	chr17	1387008	1387008	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgacagagaccaggacgggGccaatgtaggtctgggatcg	10	7	16	8	2	1	2	0	1	1	1	2	5	1	4	2	5	0	1	2	5	2	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:1387008G>A	uc002fsp.2	-	3	463	c.243C>T	c.(241-243)GGC>GGT	p.G81G	MYO1C_uc002fsn.2_Silent_p.G62G|MYO1C_uc002fso.2_Silent_p.G46G|MYO1C_uc010vqj.1_Silent_p.G46G|MYO1C_uc010vqk.1_Silent_p.G57G	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	81	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCAGGACGGGGCCAATGTAGG	0.433													3	16					0	0	0	0	A	1387008	A	A	1387008	2	1	210	1	0	0	0	0	0	0	0	1	10123	1190	42	4		4	MYO1C	17	1387008	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08		1387008	79808202	119	38351											
PRPF8	10594	broad.mit.edu	37	chr17	1562841	1562841	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtggtgctgtccatcacatCcctgaggatgaagagggttc	8	10	14	9	0	1	3	1	2	0	1	4	4	3	4	2	4	1	2	2	4	1	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:1562841C>A	uc002fte.2	-	32	5062	c.4948G>T	c.(4948-4950)GAT>TAT	p.D1650Y		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1650						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCCATCACATCCCTGAGGATG	0.527													9	78					0.000274275	0.000294885	1	0	A	1562841	A	A	1562841	3	1	210	1	0	0	0	0	1	0	0	0	12637	869	30	2	2107	2	PRPF8	17	1562841	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	175833	1562841	79632369	120	38352											
MYOCD	93649	broad.mit.edu	37	chr17	12666526	12666526	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcctcttcaggcagccagatCccctttgatccctatgccac	7	10	7	17	0	2	2	1	1	1	1	4	2	4	2	6	1	2	1	6	1	1	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:12666526C>G	uc002gnn.2	+	13	2681	c.2382C>G	c.(2380-2382)ATC>ATG	p.I794M	MYOCD_uc002gno.2_Missense_Mutation_p.I842M|MYOCD_uc002gnq.2_Missense_Mutation_p.I518M	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	794					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GCAGCCAGATCCCCTTTGATC	0.483													6	110					0	0	0	0	G	12666526	G	G	12666526	3	3	210	1	0	0	0	0	1	0	0	0	10140	845	30	2	2592	2	MYOCD	17	12666526	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	11103685	12666526	68528684	121	38353											
SREBF1	6720	broad.mit.edu	37	chr17	17718569	17718569	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgacccagggctggggttggGctgggtcacacagttcagtg	6	9	17	9	0	2	1	2	1	0	0	2	1	2	1	1	5	0	4	1	5	0	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:17718569G>A	uc002gru.1	-	13	2652	c.2458C>T	c.(2458-2460)CCC>TCC	p.P820S	SREBF1_uc002grp.1_Missense_Mutation_p.P439S|SREBF1_uc002grq.1_Missense_Mutation_p.P339S|SREBF1_uc002grr.1_Missense_Mutation_p.P566S|SREBF1_uc002grs.1_Missense_Mutation_p.P796S|SREBF1_uc002grt.1_Missense_Mutation_p.P850S|MIR33B_hsa-mir-33b|MI0003646_5'Flank	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	820	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						CTGGGGTTGGGCTGGGTCACA	0.617													8	104					0	0	0	0	A	17718569	A	A	17718569	3	1	210	1	0	0	0	0	1	0	0	0	15207	1203	42	4	1013	4	SREBF1	17	17718569	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	5052043	17718569	63476641	122	38354											
MYO15A	51168	broad.mit.edu	37	chr17	18040913	18040913	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggacctgagcttcaacAgctttgagcagctgtgtatt	9	11	12	9	0	1	2	1	2	0	0	1	3	1	3	1	2	5	6	1	2	2	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:18040913A>G	uc010vxh.1	+	15	5133	c.4795A>G	c.(4795-4797)AGC>GGC	p.S1599G		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1599	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GAGCTTCAACAGCTTTGAGCA	0.532													5	56					0	0	0	0	G	18040913	G	G	18040913	3	3	210	1	0	0	0	0	1	0	0	0	10116	188	7	5	4849	5	MYO15A	17	18040913	Missense_Mutation	SNP	A	TCGA-CV-6955-01A-11D-2012-08	322344	18040913	63154297	123	38355											
KIAA0100	9703	broad.mit.edu	37	chr17	26948139	26948139	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggcagttgcaacgcgaaatGatccgctggacttgctgggc	8	8	14	11	4	0	1	0	1	0	0	1	3	1	2	1	3	3	5	1	3	2	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:26948139G>A	uc002hbu.2	-	28	5208	c.5109C>T	c.(5107-5109)ATC>ATT	p.I1703I	KIAA0100_uc002hbt.2_Silent_p.I32I	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1703						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AACGCGAAATGATCCGCTGGA	0.448													4	64					0	0	0	0	A	26948139	A	A	26948139	2	1	210	1	0	0	0	0	0	0	0	1	8193	1280	45	2		2	KIAA0100	17	26948139	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	8907226	26948139	54247071	124	38356											
AOC3	8639	broad.mit.edu	37	chr17	41004139	41004139	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgaccctgcccgctggaCtatccagaaggtgttctatc	7	11	9	14	1	1	2	0	1	1	1	3	3	2	3	4	2	1	2	4	2	3	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:41004139C>T	uc002ibv.2	+	1	939	c.779C>T	c.(778-780)ACT>ATT	p.T260I		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	260	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	GCCCGCTGGACTATCCAGAAG	0.597													9	40					0	0	0	0	T	41004139	T	T	41004139	3	4	210	1	0	0	0	0	1	0	0	0	728	565	20	4	781	4	AOC3	17	41004139	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	14056000	41004139	40191071	125	38357											
GPATCH8	23131	broad.mit.edu	37	chr17	42475597	42475597	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taggatccccactgggaggtGcataactggggaaatgctca	11	8	13	9	0	1	0	1	0	0	0	2	3	2	3	2	5	3	2	2	5	3	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:42475597G>A	uc002igw.1	-	8	3912	c.3848C>T	c.(3847-3849)GCA>GTA	p.A1283V	GPATCH8_uc002igv.1_Missense_Mutation_p.A1205V|GPATCH8_uc010wiz.1_Missense_Mutation_p.A1205V	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1283						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ACTGGGAGGTGCATAACTGGG	0.592													7	177					0	0	0	0	A	42475597	A	A	42475597	3	1	210	1	0	0	0	0	1	0	0	0	6632	1319	46	4	664	4	GPATCH8	17	42475597	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	1471458	42475597	38719613	126	38358											
DNAH17	8632	broad.mit.edu	37	chr17	76506502	76506502	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccttcacggccttgtccacGatgttgcggacctcatcctc	5	12	8	16	3	2	0	2	0	0	0	6	2	5	1	5	2	1	1	5	2	0	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:76506502G>A	uc010wtu.1	-	1	252	c.75C>T	c.(73-75)ATC>ATT	p.I25I						full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCTTGTCCACGATGTTGCGGA	0.532													7	199					0	0	0	0	A	76506502	A	A	76506502	2	1	210	1	0	0	0	0	0	0	0	1	4623	1048	37	1		1	DNAH17	17	76506502	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	34030905	76506502	4688708	127	38359											
SIRT7	51547	broad.mit.edu	37	chr17	79872320	79872320	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccacacttgtggcaggtccgGcctgtctggtgtctgtggag	4	11	15	11	1	2	0	0	0	2	0	3	1	3	1	3	5	0	1	3	5	0	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:79872320G>A	uc002kcj.1	-	7	699	c.666C>T	c.(664-666)GGC>GGT	p.G222G	SIRT7_uc002kck.1_Silent_p.G73G|SIRT7_uc002kcl.1_Silent_p.G140G	NM_016538	NP_057622	Q9NRC8	SIRT7_HUMAN	sirtuin 7	222	Deacetylase sirtuin-type.				chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GGCAGGTCCGGCCTGTCTGGT	0.632													9	28					0	0	0	0	A	79872320	A	A	79872320	2	1	210	1	0	0	0	0	0	0	0	1	14408	1190	42	4		4	SIRT7	17	79872320	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	3365818	79872320	1322890	128	38360											
UTS2R	2837	broad.mit.edu	37	chr17	80332288	80332288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccgcctggcggccccaacGcaaccctcaacagctcctgg	8	4	10	19	3	1	0	1	0	0	0	2	0	2	0	6	3	5	2	6	3	3	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr17:80332288G>A	uc010wvl.1	+	1	88	c.88G>A	c.(88-90)GCA>ACA	p.A30T		NM_018949	NP_061822	Q9UKP6	UR2R_HUMAN	urotensin 2 receptor	30	Extracellular (Potential).					integral to membrane|plasma membrane				breast(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			CGGCCCCAACGCAACCCTCAA	0.711													3	14					0	0	0	0	A	80332288	A	A	80332288	3	1	210	1	0	0	0	0	1	0	0	0	17174	1087	38	1	90	1	UTS2R	17	80332288	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	459968	80332288	862922	129	38361											
DPP9	91039	broad.mit.edu	37	chr19	4704050	4704050	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actgggtcttgatttccagcGgtttcataggggacacctga	8	12	12	9	1	2	2	1	2	1	0	3	3	3	3	2	4	1	1	2	4	1	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:4704050G>A	uc002mba.2	-	7	875	c.617C>T	c.(616-618)CCG>CTG	p.P206L	DPP9_uc002mbb.2_Missense_Mutation_p.P206L|DPP9_uc002mbc.2_Missense_Mutation_p.P206L	NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	177					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		GATTTCCAGCGGTTTCATAGG	0.632													8	41					0	0	0	0	A	4704050	A	A	4704050	3	1	210	1	0	0	0	0	1	0	0	0	4755	1116	39	1	2125	1	DPP9	19	4704050	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08		4704050	54424933	130	38362											
MYO9B	4650	broad.mit.edu	37	chr19	17294679	17294680	+	Splice_Site	INS	-	A	A																															aagcagatcattccaaaggtINSaaaaaaaaaaacacaccccg																										TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr19:17294679_17294680insA	uc010eak.2	+	16	2525	c.2373_splice	c.e16+2	p.K791_splice	MYO9B_uc002nfi.2_Splice_Site_p.K791_splice|MYO9B_uc002nfj.1_Splice_Site_p.K791_splice	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1						actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						ATTCCAAAGGTAAAAAAAAAAA	0.411													---	---	---								A	17294680	A	A	17294679	8	5	210	1	0	1	1	0	0	0	1	0	10138	1652	57	0	2433	0	MYO9B	19	17294679	Splice_Site	INS	-	TCGA-CV-6955-01A-11D-2012-08	12590629	17294679	41834304	131	38363											
HOMER3	9454	broad.mit.edu	37	chr19	19042181	19042181	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcggcagcctccagggcctCgcggggccccccagtctgac	4	5	13	19	3	1	1	0	1	1	0	4	1	2	1	6	4	1	1	6	4	0	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:19042181C>T	uc002nku.2	-	8	1500	c.847G>A	c.(847-849)GAG>AAG	p.E283K	HOMER3_uc002nko.1_RNA|HOMER3_uc002nkp.1_RNA|HOMER3_uc010eby.2_Missense_Mutation_p.E247K|HOMER3_uc010ebz.2_Missense_Mutation_p.E283K|HOMER3_uc002nkw.2_Missense_Mutation_p.E283K|HOMER3_uc002nkv.2_Missense_Mutation_p.E283K	NM_004838	NP_004829	Q9NSC5	HOME3_HUMAN	Homer, neuronal immediate early gene, 3 isoform	283	Potential.				metabotropic glutamate receptor signaling pathway|protein targeting	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	protein binding				0			Epithelial(12;0.0107)			TCCAGGGCCTCGCGGGGCCCC	0.627													6	99					0	0	0	0	T	19042181	T	T	19042181	3	4	210	1	0	0	0	0	1	0	0	0	7319	893	31	1	246	1	HOMER3	19	19042181	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	1747502	19042181	40086802	132	38364											
ZNF527	84503	broad.mit.edu	37	chr19	37880095	37880095	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacatcagagaattcacacaGgtgagaaaccatatgaatgt	18	8	8	7	0	2	3	2	2	0	2	2	5	2	3	1	1	2	0	1	1	5	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:37880095G>T	uc010efk.1	+	5	1255	c.1144G>T	c.(1144-1146)GGT>TGT	p.G382C	ZNF527_uc002ogf.3_Missense_Mutation_p.G350C|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AATTCACACAGGTGAGAAACC	0.433													8	38					1.12685e-05	1.25506e-05	1	0	T	37880095	T	T	37880095	3	4	210	1	0	0	0	0	1	0	0	0	18035	1000	35	4	1158	4	ZNF527	19	37880095	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	18837914	37880095	21248888	133	38365											
PSG1	5669	broad.mit.edu	37	chr19	43382262	43382262	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctactacatatgatgtaatgTaatggtagaggtccctcatt	12	14	8	7	0	1	2	1	1	0	1	2	2	2	2	1	2	2	3	1	2	6	7			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:43382262T>C	uc002ovb.2	-	2	371	c.233A>G	c.(232-234)TAC>TGC	p.Y78C	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.Y78C|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.Y78C|PSG1_uc010eio.1_Missense_Mutation_p.Y78C|PSG1_uc002oux.1_Missense_Mutation_p.Y7C|PSG1_uc002ouy.1_Missense_Mutation_p.Y78C|PSG1_uc002ouz.1_Missense_Mutation_p.Y78C|PSG1_uc002ova.1_Missense_Mutation_p.Y78C|PSG1_uc002ovc.2_Missense_Mutation_p.Y78C|PSG1_uc002ovd.1_Missense_Mutation_p.Y78C	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	78	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TGATGTAATGTAATGGTAGAG	0.433													63	268					0	0	0	0	C	43382262	C	C	43382262	3	2	210	1	0	0	0	0	1	0	0	0	12715	1638	57	5	1099	5	PSG1	19	43382262	Missense_Mutation	SNP	T	TCGA-CV-6955-01A-11D-2012-08	5502167	43382262	15746721	134	38366											
ZNF471	57573	broad.mit.edu	37	chr19	57037232	57037232	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccacactggccaaaggccctAtcagtgttttgaatgtggga	10	10	11	10	0	1	1	1	1	0	0	1	2	1	2	3	3	0	1	3	3	3	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:57037232A>G	uc002qnh.2	+	5	1929	c.1796A>G	c.(1795-1797)TAT>TGT	p.Y599C		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	599	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		CAAAGGCCCTATCAGTGTTTT	0.413													10	42					0	0	0	0	G	57037232	G	G	57037232	3	3	210	1	0	0	0	0	1	0	0	0	17997	449	16	5	1810	5	ZNF471	19	57037232	Missense_Mutation	SNP	A	TCGA-CV-6955-01A-11D-2012-08	13654970	57037232	2091751	135	38367											
PEG3	5178	broad.mit.edu	37	chr19	57327549	57327549	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctggttttcataggggttaGagctaatggtgaacgccttt	8	15	12	6	1	2	2	1	1	1	1	2	2	2	2	1	4	2	3	1	4	4	6			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr19:57327549G>A	uc002qnu.2	-	7	2612	c.2261C>T	c.(2260-2262)TCT>TTT	p.S754F	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.S725F|PEG3_uc002qnv.2_Missense_Mutation_p.S754F|PEG3_uc002qnw.2_Missense_Mutation_p.S630F|PEG3_uc002qnx.2_Missense_Mutation_p.S628F|PEG3_uc010etr.2_Missense_Mutation_p.S754F	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	754					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ATAGGGGTTAGAGCTAATGGT	0.413													10	164					0	0	0	0	A	57327549	A	A	57327549	3	1	210	1	0	0	0	0	1	0	0	0	11774	942	33	2	2509	2	PEG3	19	57327549	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	290317	57327549	1801434	136	38368											
SEC23B	10483	broad.mit.edu	37	chr20	18485750	18485751	+	5'Flank	INS	-	AA	AA																															taatacattgcctcattcagINSaaaaaaaaaaaaaaattagg																								rs74180905		TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	02a4bd93-e180-4e48-b703-c6e0262aaa96	g.chr20:18485750_18485751insAA	uc002wqz.1	+						SEC23B_uc002wra.1_5'Flank|SEC23B_uc002wrb.1_5'Flank|SEC23B_uc010zsb.1_5'Flank|SEC23B_uc002wrc.1_5'Flank	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B						ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						GCCTCATTCAGAAAAAAAAAAA	0.371													---	---	---								AA	18485751	AA	AA	18485750	6	5	210	0	1	1	1	0	0	0	0	0	14057	957	33	0		0	SEC23B	20	18485750	5'Flank	INS	-	TCGA-CV-6955-01A-11D-2012-08		18485750	44539770	137	38369											
DIDO1	11083	broad.mit.edu	37	chr20	61542619	61542619	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctggtctcagaagcgctttCcacgctgccctcggaggctg	5	10	12	14	3	2	1	1	0	2	1	5	2	3	2	2	3	2	3	2	3	1	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr20:61542619C>T	uc002ydr.1	-	3	610	c.346G>A	c.(346-348)GAA>AAA	p.E116K	DIDO1_uc002yds.1_Missense_Mutation_p.E116K|DIDO1_uc002ydt.1_Missense_Mutation_p.E116K|DIDO1_uc002ydu.1_Missense_Mutation_p.E116K|DIDO1_uc002ydv.1_Missense_Mutation_p.E116K|DIDO1_uc002ydw.1_Missense_Mutation_p.E116K|DIDO1_uc002ydx.1_Missense_Mutation_p.E116K|DIDO1_uc011aao.1_Missense_Mutation_p.E116K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	116					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GAAGCGCTTTCCACGCTGCCC	0.637													6	41					0	0	0	0	T	61542619	T	T	61542619	3	4	210	1	0	0	0	0	1	0	0	0	4544	864	30	2	6562	2	DIDO1	20	61542619	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	43056869	61542619	1482901	138	38370											
ARFGAP1	55738	broad.mit.edu	37	chr20	61914181	61914181	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcattttaggctacaaagtTtggatcccaagcgagtcaga	12	12	9	8	1	2	1	2	0	0	1	3	3	3	2	1	2	2	2	1	2	4	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr20:61914181T>G	uc002yem.2	+	9	807	c.695T>G	c.(694-696)TTT>TGT	p.F232C	ARFGAP1_uc011aas.1_Missense_Mutation_p.F179C|ARFGAP1_uc011aat.1_Missense_Mutation_p.F119C|ARFGAP1_uc002yel.2_Missense_Mutation_p.F232C|ARFGAP1_uc002yen.2_Missense_Mutation_p.F232C|ARFGAP1_uc002yeo.1_5'Flank	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	232					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					GCTACAAAGTTTGGATCCCAA	0.507													15	42					0	0	0	0	G	61914181	G	G	61914181	3	3	210	1	0	0	0	0	1	0	0	0	849	1841	64	5	725	5	ARFGAP1	20	61914181	Missense_Mutation	SNP	T	TCGA-CV-6955-01A-11D-2012-08	371562	61914181	1111339	139	38371											
TPTE	7179	broad.mit.edu	37	chr21	10996103	10996103	+	RNA	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttttggttttcccttgcccaGttcgacttctttgccgcacc	3	17	7	14	2	1	0	0	0	1	0	3	1	2	0	4	1	2	3	4	1	0	8			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr21:10996103G>C	uc002yis.1	-	12		c.2083C>G						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCCTTGCCCAGTTCGACTTCT	0.408													4	59					0	0	0	0	C	10996103	C	C	10996103	1	2	210	0	1	0	0	0	0	0	0	0	16497	1044	36	4		4	TPTE	21	10996103	RNA	SNP	G	TCGA-CV-6955-01A-11D-2012-08		10996103	37133792	140	38372											
TMPRSS15	5651	broad.mit.edu	37	chr21	19704465	19704465	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgttgtatttggctcccaCagctcaaaaggtcctccaca	11	11	7	12	0	1	0	1	0	0	0	4	0	4	0	3	2	1	4	3	2	4	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr21:19704465C>G	uc002ykw.2	-	14	1621	c.1590G>C	c.(1588-1590)CTG>CTC	p.L530L		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	530	Extracellular (Potential).|CUB 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TTGGCTCCCACAGCTCAAAAG	0.403													4	56					0	0	0	0	G	19704465	G	G	19704465	2	3	210	1	0	0	0	0	0	0	0	1	16312	465	17	4		4	TMPRSS15	21	19704465	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	8708362	19704465	28425430	141	38373											
CECR5	27440	broad.mit.edu	37	chr22	17629399	17629399	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catccgcttctcatggtactCggagaagagcttcatggggc	8	10	12	11	2	2	2	2	0	1	2	5	3	3	2	1	4	2	3	1	4	2	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr22:17629399C>T	uc002zmf.2	-	3	410	c.382G>A	c.(382-384)GAG>AAG	p.E128K	CECR5_uc002zme.2_5'UTR|CECR5_uc002zmg.2_Intron|CECR5_uc002zmh.2_Missense_Mutation_p.E98K	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	128							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				TCATGGTACTCGGAGAAGAGC	0.557													14	260					0	0	0	0	T	17629399	T	T	17629399	3	4	210	1	0	0	0	0	1	0	0	0	3222	893	31	1	913	1	CECR5	22	17629399	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08		17629399	33675167	142	38374											
SREBF2	6721	broad.mit.edu	37	chr22	42294718	42294718	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcagctggctccagggaGacgatgcagctgtgcgctct	7	8	13	13	2	2	1	1	0	1	1	3	3	3	1	2	2	4	5	2	2	0	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr22:42294718G>T	uc003bbi.2	+	15	2840	c.2671G>T	c.(2671-2673)GAC>TAC	p.D891Y	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA|uc011api.1_5'Flank|MIR33A_hsa-mir-33a|MI0000091_5'Flank	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	891	Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						GCTCCAGGGAGACGATGCAGC	0.567													13	23					9.31168e-06	1.04336e-05	1	0	T	42294718	T	T	42294718	3	4	210	1	0	0	0	0	1	0	0	0	15208	942	33	2	2729	2	SREBF2	22	42294718	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	24665319	42294718	9009848	143	38375											
MPPED1	758	broad.mit.edu	37	chr22	43870809	43870809	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcaggactcggaggtcacCgtgcggggcttccggatcta	6	9	14	12	4	3	0	2	0	1	0	5	3	4	3	2	6	1	1	2	6	1	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chr22:43870809C>T	uc011apv.1	+	4	823	c.600C>T	c.(598-600)ACC>ACT	p.T200T	MPPED1_uc011apw.1_Silent_p.T94T|MPPED1_uc011apx.1_Silent_p.T42T|MPPED1_uc011apy.1_Silent_p.T200T|MPPED1_uc011apz.1_Silent_p.T233T	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	200							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				CGGAGGTCACCGTGCGGGGCT	0.522													24	54					0	0	0	0	T	43870809	T	T	43870809	2	4	210	1	0	0	0	0	0	0	0	1	9794	639	23	1		1	MPPED1	22	43870809	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	1576091	43870809	7433757	144	38376											
RBBP7	5931	broad.mit.edu	37	chrX	16863980	16863980	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatctgcatgatgttatcctCagacactgagcaaatgaccc	12	11	7	11	0	2	4	1	3	1	1	3	4	3	4	2	0	2	3	2	0	3	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:16863980C>G	uc004cxt.2	-	11	1538	c.1180G>C	c.(1180-1182)GAG>CAG	p.E394Q	RBBP7_uc004cxs.1_Missense_Mutation_p.E438Q|RBBP7_uc004cxu.2_Missense_Mutation_p.E385Q	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	394	WD 7.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					ATGTTATCCTCAGACACTGAG	0.353													4	45					0	0	0	0	G	16863980	G	G	16863980	3	3	210	1	0	0	0	0	1	0	0	0	13169	835	29	2	105	2	RBBP7	23	16863980	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08		16863980	138406580	145	38377											
RAI2	10742	broad.mit.edu	37	chrX	17819471	17819471	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgggaccaggggggacaaGggggagctaaaaggctgtgg	10	4	22	5	0	0	0	0	0	0	0	0	3	0	3	1	9	1	2	1	9	3	1			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:17819471G>T	uc004cyf.2	-	3	1230	c.660C>A	c.(658-660)CCC>CCA	p.P220P	RAI2_uc004cyg.2_Silent_p.P220P|RAI2_uc010nfa.2_Silent_p.P220P|RAI2_uc004cyh.3_Silent_p.P220P|RAI2_uc011miy.1_Silent_p.P170P	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	220	Pro-rich.				embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					GGGGGGACAAGGGGGAGCTAA	0.632													24	35					6.44725e-10	7.44838e-10	1	0	T	17819471	T	T	17819471	2	4	210	1	0	0	0	0	0	0	0	1	13074	987	35	4		4	RAI2	23	17819471	Silent	SNP	G	TCGA-CV-6955-01A-11D-2012-08	955491	17819471	137451089	146	38378											
FAM47B	170062	broad.mit.edu	37	chrX	34961653	34961653	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagactcgggtgtccagtctCcacccggaacctccagagac	10	6	10	15	2	1	2	0	0	1	2	5	4	3	3	5	2	1	0	5	2	2	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:34961653C>T	uc004ddi.1	+	1	723	c.705C>T	c.(703-705)CTC>CTT	p.L235L		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	235	Pro-rich.									ovary(3)|breast(1)	4						TGTCCAGTCTCCACCCGGAAC	0.637													6	105					0	0	0	0	T	34961653	T	T	34961653	2	4	210	1	0	0	0	0	0	0	0	1	5602	842	30	2		2	FAM47B	23	34961653	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	17142182	34961653	120308907	147	38379											
OGT	8473	broad.mit.edu	37	chrX	70787880	70787880	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgagttgcagcatcccagctCacttgcttaggttgtcttga	7	13	10	11	1	2	1	1	1	1	0	3	2	3	1	1	1	4	6	1	1	1	5			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:70787880C>T	uc004eaa.1	+	21	3097	c.2880C>T	c.(2878-2880)CTC>CTT	p.L960L	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.L950L|OGT_uc004eac.2_Silent_p.L821L|OGT_uc004ead.2_Silent_p.L579L	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	960					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					CATCCCAGCTCACTTGCTTAG	0.383													16	110					0	0	0	0	T	70787880	T	T	70787880	2	4	210	1	0	0	0	0	0	0	0	1	10901	813	29	2		2	OGT	23	70787880	Silent	SNP	C	TCGA-CV-6955-01A-11D-2012-08	35826227	70787880	84482680	148	38380											
HDX	139324	broad.mit.edu	37	chrX	83723803	83723803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcgatgccagctcttcctCtctggcatattcatcctcag	7	13	6	15	1	4	0	2	0	2	0	8	1	6	0	3	1	2	2	3	1	1	3			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:83723803C>T	uc004eek.1	-	3	1037	c.928G>A	c.(928-930)GAG>AAG	p.E310K	HDX_uc011mqv.1_Missense_Mutation_p.E310K|HDX_uc004eel.1_Missense_Mutation_p.E252K	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	310						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						AGCTCTTCCTCTCTGGCATAT	0.473													16	80					0	0	0	0	T	83723803	T	T	83723803	3	4	210	1	0	0	0	0	1	0	0	0	7065	922	32	2	1176	2	HDX	23	83723803	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	12935923	83723803	71546757	149	38381											
GLA	2717	broad.mit.edu	37	chrX	100662806	100662806	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccattgtccagtgctctaGccccagggatgtcccaggaa	9	9	10	13	0	1	0	0	0	1	0	4	2	4	2	5	2	2	1	5	2	2	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:100662806G>A	uc004ehl.1	-	1	196	c.86C>T	c.(85-87)GCT>GTT	p.A29V	HNRNPH2_uc004ehm.2_5'Flank|HNRNPH2_uc004ehn.2_5'Flank|GLA_uc011mrj.1_Missense_Mutation_p.A29V	NM_000169	NP_000160	P06280	AGAL_HUMAN	alpha-galactosidase A precursor	29					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding				0					Agalsidase beta(DB00103)	CAGTGCTCTAGCCCCAGGGAT	0.602													5	137					0	0	0	0	A	100662806	A	A	100662806	3	1	210	1	0	0	0	0	1	0	0	0	6463	971	34	4	1231	4	GLA	23	100662806	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	16939003	100662806	54607754	150	38382											
CUL4B	8450	broad.mit.edu	37	chrX	119660660	119660660	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggattttctttatctctttCcatgtagtcccggtcaatta	7	19	6	9	1	3	0	1	0	2	0	6	1	5	1	2	2	0	1	2	2	4	7			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:119660660C>T	uc004esw.2	-	22	3135	c.2698G>A	c.(2698-2700)GAA>AAA	p.E900K	CUL4B_uc010nqq.2_Missense_Mutation_p.E601K|CUL4B_uc004esv.2_Missense_Mutation_p.E882K	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	900					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						TTATCTCTTTCCATGTAGTCC	0.373													26	56					0	0	0	0	T	119660660	T	T	119660660	3	4	210	1	0	0	0	0	1	0	0	0	4075	864	30	2	47	2	CUL4B	23	119660660	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	18997854	119660660	35609900	151	38383											
CT47B1	643311	broad.mit.edu	37	chrX	120007815	120007815	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttttcttgttctttctcttCctcgcctgcagcatcttggg	2	20	7	12	1	4	0	0	0	4	0	7	0	5	0	2	1	2	3	2	1	0	7			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:120007815C>A	uc011muc.1	-	2	1090	c.835G>T	c.(835-837)GAA>TAA	p.E279*		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	279	Potential.										0						TCTTTCTCTTCCTCGCCTGCA	0.458													155	488					4.69383e-74	5.52565e-74	1	0	A	120007815	A	A	120007815	4	1	210	1	0	0	0	0	0	1	0	0	4006	864	30	2	68	2	CT47B1	23	120007815	Nonsense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	347155	120007815	35262745	152	38384											
THOC2	57187	broad.mit.edu	37	chrX	122820424	122820424	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacttgaatttgaacccaaGaatatgacacagtgtttgcg	15	11	8	7	1	0	4	0	3	0	1	0	4	0	4	1	0	3	1	1	0	6	4			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:122820424G>C	uc004etu.2	-	8	774	c.742C>G	c.(742-744)CTT>GTT	p.L248V	THOC2_uc011muh.1_Missense_Mutation_p.L169V|THOC2_uc011mui.1_Missense_Mutation_p.L133V	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	248					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TTGAACCCAAGAATATGACAC	0.299													6	49					0	0	0	0	C	122820424	C	C	122820424	3	2	210	1	0	0	0	0	1	0	0	0	15931	942	33	2	4163	2	THOC2	23	122820424	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	2812609	122820424	32450136	153	38385											
GPR112	139378	broad.mit.edu	37	chrX	135429169	135429169	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgtcaggaagacatccatgGcagttccttctctgacagaa	11	10	9	11	0	2	3	1	1	1	2	5	4	4	4	2	2	0	2	2	2	2	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:135429169G>T	uc004ezu.1	+	6	3595	c.3304G>T	c.(3304-3306)GCA>TCA	p.A1102S	GPR112_uc010nsb.1_Missense_Mutation_p.A897S|GPR112_uc010nsc.1_Missense_Mutation_p.A869S	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1102	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GACATCCATGGCAGTTCCTTC	0.478													11	212					1.33987e-11	1.5576e-11	1	0	T	135429169	T	T	135429169	3	4	210	1	0	0	0	0	1	0	0	0	6667	1203	42	4	3314	4	GPR112	23	135429169	Missense_Mutation	SNP	G	TCGA-CV-6955-01A-11D-2012-08	12608745	135429169	19841391	154	38386											
SOX3	6658	broad.mit.edu	37	chrX	139586097	139586097	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggcggcggcgagctgggctCagacttcactaccgagccca	7	5	15	14	4	2	1	2	0	0	1	2	3	2	1	2	4	3	2	2	4	1	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:139586097C>G	uc004fbd.1	-	1	1129	c.1129G>C	c.(1129-1131)GAG>CAG	p.E377Q		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	377					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					GAGCTGGGCTCAGACTTCACT	0.473													4	16					0	0	0	0	G	139586097	G	G	139586097	3	3	210	1	0	0	0	0	1	0	0	0	15015	835	29	2	215	2	SOX3	23	139586097	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	4156928	139586097	15684463	155	38387											
MAGEA6	4105	broad.mit.edu	37	chrX	151870209	151870209	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagtggaggacctcgcatttCctacccactcctgcatgagt	8	10	9	14	1	0	1	0	1	0	0	3	3	2	3	4	2	2	2	4	2	1	2			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:151870209C>A	uc004ffq.1	+	3	1093	c.899C>A	c.(898-900)TCC>TAC	p.S300Y	MAGEA6_uc004ffr.1_Missense_Mutation_p.S300Y|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	300	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCGCATTTCCTACCCACTC	0.562													7	227					5.18039e-06	5.83971e-06	1	0	A	151870209	A	A	151870209	3	1	210	1	0	0	0	0	1	0	0	0	9221	855	30	2	901	2	MAGEA6	23	151870209	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	12284112	151870209	3400351	156	38388											
ATP2B3	492	broad.mit.edu	37	chrX	152821580	152821580	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactggggacaacatcaacaCggcccgggccatcgcagcca	11	3	12	15	3	1	0	1	0	0	0	2	2	1	1	3	4	3	1	3	4	2	0			TCGA-CV-6955-01A-11D-2012-08	TCGA-CV-6955-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f2c7fbe1-af36-4c42-b5ae-b9bf1e88fe36	483fb0b9-330d-47a6-b13b-b7611f022788	g.chrX:152821580C>T	uc004fht.1	+	12	2258	c.2132C>T	c.(2131-2133)ACG>ATG	p.T711M	ATP2B3_uc004fhs.1_Missense_Mutation_p.T711M	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	711	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AACATCAACACGGCCCGGGCC	0.592													26	99					0	0	0	0	T	152821580	T	T	152821580	3	4	210	1	0	0	0	0	1	0	0	0	1143	536	19	1	2178	1	ATP2B3	23	152821580	Missense_Mutation	SNP	C	TCGA-CV-6955-01A-11D-2012-08	951371	152821580	2448980	157	38389											
SPEN	23013	broad.mit.edu	37	chr1	16254612	16254612	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acgaagggcatcctacgactAtaaccaagatcgtacatatt	15	9	7	10	3	0	1	0	0	0	1	2	3	1	1	2	1	3	2	2	1	7	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:16254612A>G	uc001axk.1	+	11	2081	c.1877A>G	c.(1876-1878)TAT>TGT	p.Y626C	SPEN_uc010obp.1_Missense_Mutation_p.Y585C	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	626	Arg-rich.|Tyr-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TCCTACGACTATAACCAAGAT	0.398													19	24					0	0	0	0	G	16254612	G	G	16254612	3	3	211	1	0	0	0	0	1	0	0	0	15104	449	16	5	1919	5	SPEN	1	16254612	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08		16254612	232996009	1	38390											
LAPTM5	7805	broad.mit.edu	37	chr1	31210496	31210496	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgatggaaaagatgatcatCatcttgatgaactggttatg	13	12	11	5	1	3	4	2	3	1	1	3	6	3	5	0	2	1	1	0	2	4	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:31210496C>A	uc001bsc.2	-	6	652	c.561G>T	c.(559-561)ATG>ATT	p.M187I		NM_006762	NP_006753	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	187	Helical; (Potential).				transport	integral to plasma membrane|lysosomal membrane					0		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		AGATGATCATCATCTTGATGA	0.522													23	45					7.07758e-08	7.91024e-08	1	0	A	31210496	A	A	31210496	3	1	211	1	0	0	0	0	1	0	0	0	8666	826	29	2	239	2	LAPTM5	1	31210496	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	14955884	31210496	218040125	2	38391											
EIF2C1	26523	broad.mit.edu	37	chr1	36372612	36372612	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcaaccttgtttctgcaaaTatgcacagggggcagacagc	11	9	11	10	0	2	1	1	0	1	1	2	1	2	1	1	2	4	4	1	2	3	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:36372612T>G	uc001bzl.2	+	12	1687	c.1474T>G	c.(1474-1476)TAT>GAT	p.Y492D	EIF2C1_uc001bzk.2_Missense_Mutation_p.Y417D|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	492					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTTCTGCAAATATGCACAGGG	0.537													37	52					0	0	0	0	G	36372612	G	G	36372612	3	3	211	1	0	0	0	0	1	0	0	0	5027	1406	49	5	1520	5	EIF2C1	1	36372612	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	5162116	36372612	212878009	3	38392											
C1orf168	199920	broad.mit.edu	37	chr1	57257988	57257988	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttgcccttccagatggatGgccttacttccatagttggc	6	15	9	11	0	0	1	0	0	0	1	2	2	2	2	4	3	2	1	4	3	2	7			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:57257988G>T	uc001cym.3	-	2	904	c.498C>A	c.(496-498)GCC>GCA	p.A166A	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Silent_p.A166A	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	166										ovary(3)|skin(2)	5						CCAGATGGATGGCCTTACTTC	0.483													37	62					1.836e-18	2.25058e-18	1	0	T	57257988	T	T	57257988	2	4	211	1	0	0	0	0	0	0	0	1	2021	1335	47	4		4	C1orf168	1	57257988	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	20885376	57257988	191992633	4	38393											
MCOLN3	55283	broad.mit.edu	37	chr1	85491754	85491754	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccttcttataatggaggagGaaaaaattgacaaactcctt	15	12	7	7	0	1	1	0	1	1	0	3	4	3	4	2	3	1	0	2	3	6	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:85491754G>T	uc001dkp.2	-	9	1056	c.963C>A	c.(961-963)TTC>TTA	p.F321L	MCOLN3_uc001dko.2_5'Flank|MCOLN3_uc001dkq.2_Missense_Mutation_p.F265L|MCOLN3_uc001dkr.2_3'UTR|MCOLN3_uc001dks.3_Missense_Mutation_p.F166L	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	321						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		AATGGAGGAGGAAAAAATTGA	0.363													10	16					2.80697e-09	3.16379e-09	1	0	T	85491754	T	T	85491754	3	4	211	1	0	0	0	0	1	0	0	0	9450	1165	41	2	718	2	MCOLN3	1	85491754	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	28233766	85491754	163758867	5	38394											
DPYD	1806	broad.mit.edu	37	chr1	97915726	97915726	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttgtccagggccatacatGgggccagaggtggttccccg	6	9	14	12	1	0	1	0	0	0	1	2	1	2	1	5	5	1	1	5	5	1	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:97915726G>C	uc001drv.2	-	14	1931	c.1794C>G	c.(1792-1794)CCC>CCG	p.P598P		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	598					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GGCCATACATGGGGCCAGAGG	0.448													28	52					0	0	0	0	C	97915726	C	C	97915726	2	2	211	1	0	0	0	0	0	0	0	1	4767	1335	47	4		4	DPYD	1	97915726	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	12423972	97915726	151334895	6	38395											
TARS2	80222	broad.mit.edu	37	chr1	150478094	150478094	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagcctgcgggctgcaggaCtggtcagtgacctggatgca	8	7	16	10	1	1	2	1	1	0	1	1	4	1	4	2	4	4	3	2	4	0	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:150478094C>A	uc001euq.2	+	17	1928	c.1921C>A	c.(1921-1923)CTG>ATG	p.L641M	TARS2_uc001eur.2_Missense_Mutation_p.L559M|TARS2_uc009wlt.2_Missense_Mutation_p.L267M|TARS2_uc009wls.2_Missense_Mutation_p.L511M|ECM1_uc010pce.1_5'Flank|ECM1_uc010pcf.1_5'Flank|ECM1_uc001eus.2_5'Flank|ECM1_uc001eut.2_5'Flank|ECM1_uc001euu.2_5'Flank|ECM1_uc001euv.2_5'Flank|ECM1_uc009wlu.2_5'Flank	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	641					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	GGCTGCAGGACTGGTCAGTGA	0.527													42	69					4.0306e-16	4.85131e-16	1	0	A	150478094	A	A	150478094	3	1	211	1	0	0	0	0	1	0	0	0	15626	564	20	4	1987	4	TARS2	1	150478094	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	52562368	150478094	98772527	7	38396											
VPS72	6944	broad.mit.edu	37	chr1	151150569	151150569	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	attatgggcccggggcacttCcgcttcttatgaacctgctt	6	13	10	12	2	1	1	0	1	1	0	2	1	2	1	3	3	2	3	3	3	3	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:151150569C>T	uc001exe.1	-	5	658	c.615G>A	c.(613-615)CGG>CGA	p.R205R	TMOD4_uc001exd.2_5'Flank|TMOD4_uc001exc.3_5'Flank|TMOD4_uc010pct.1_5'Flank|VPS72_uc001exf.1_Silent_p.R205R	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	205	Potential.				chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CGGGGCACTTCCGCTTCTTAT	0.493													19	57					0	0	0	0	T	151150569	T	T	151150569	2	4	211	1	0	0	0	0	0	0	0	1	17285	842	30	2		2	VPS72	1	151150569	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	672475	151150569	98100052	8	38397											
FAM189B	10712	broad.mit.edu	37	chr1	155223908	155223908	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaagtctcgggccagttgAgcattcttacaggagagaac	11	9	13	8	1	2	2	0	1	2	1	3	5	2	4	1	3	3	2	1	3	3	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:155223908A>T	uc001fjm.2	-	3	966	c.360T>A	c.(358-360)GCT>GCA	p.A120A	RAG1AP1_uc010pey.1_Intron|FAM189B_uc009wql.2_5'Flank|FAM189B_uc001fjn.2_Intron|FAM189B_uc001fjo.2_Silent_p.A101A|FAM189B_uc001fjp.2_Intron|FAM189B_uc001fjq.1_Silent_p.A120A	NM_006589	NP_006580	P81408	F189B_HUMAN	hypothetical protein LOC10712 isoform a	120						integral to membrane	WW domain binding			ovary(1)|breast(1)	2						GGGCCAGTTGAGCATTCTTAC	0.532													83	111					0	0	0	0	T	155223908	T	T	155223908	2	4	211	1	0	0	0	0	0	0	0	1	5545	291	11	5		5	FAM189B	1	155223908	Silent	SNP	A	TCGA-CV-6956-01A-21D-2012-08	4073339	155223908	94026713	9	38398											
SLAMF6	114836	broad.mit.edu	37	chr1	160466073	160466073	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttcattgaaaagccaagTgatgaagttgaccttctctc	11	14	8	8	0	2	4	1	4	1	0	4	4	2	4	2	0	1	2	2	0	4	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:160466073T>G	uc001fwe.1	-	2	220	c.160A>C	c.(160-162)ACT>CCT	p.T54P	SLAMF6_uc001fwd.1_Missense_Mutation_p.T54P|SLAMF6_uc010pjh.1_Intron|SLAMF6_uc010pji.1_Intron|SLAMF6_uc010pjj.1_Intron|SLAMF6_uc009wtm.1_Intron	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	54	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			AAAAGCCAAGTGATGAAGTTG	0.463													48	135					0	0	0	0	G	160466073	G	G	160466073	3	3	211	1	0	0	0	0	1	0	0	0	14433	1696	59	5	866	5	SLAMF6	1	160466073	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	5242165	160466073	88784548	10	38399											
SELP	6403	broad.mit.edu	37	chr1	169576215	169576215	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctggaggaacagaattccaGtttccagtagccaagcactg	12	9	10	10	0	1	1	0	0	1	1	3	3	3	3	3	2	3	3	3	2	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:169576215G>C	uc001ggi.3	-	9	1556	c.1491C>G	c.(1489-1491)AAC>AAG	p.N497K	SELP_uc001ggh.2_Missense_Mutation_p.N332K|SELP_uc009wvr.2_Missense_Mutation_p.N497K	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	497	Extracellular (Potential).|Sushi 5.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CAGAATTCCAGTTTCCAGTAG	0.453													38	40					0	0	0	0	C	169576215	C	C	169576215	3	2	211	1	0	0	0	0	1	0	0	0	14084	1020	36	4	1033	4	SELP	1	169576215	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	9110142	169576215	79674406	11	38400											
SMG7	9887	broad.mit.edu	37	chr1	183518407	183518407	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctctttcctgtccctcaccgGattctctctcaatcaggtag	6	14	6	15	1	5	0	3	0	3	0	9	1	7	1	3	2	0	1	3	2	2	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:183518407G>T	uc001gqg.2	+	18	2929	c.2807G>T	c.(2806-2808)GGA>GTA	p.G936V	SMG7_uc001gqf.2_Missense_Mutation_p.G940V|SMG7_uc001gqh.2_Missense_Mutation_p.G890V|SMG7_uc001gqi.2_Missense_Mutation_p.G848V|SMG7_uc010poc.1_Missense_Mutation_p.G944V	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	936	Ser-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCCCTCACCGGATTCTCTCTC	0.403													18	26					0.000132079	0.000139972	1	0	T	183518407	T	T	183518407	3	4	211	1	0	0	0	0	1	0	0	0	14862	1174	41	2	3031	2	SMG7	1	183518407	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	13942192	183518407	65732214	12	38401											
CR1	1378	broad.mit.edu	37	chr1	207760880	207760880	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctcctgcctagaaaacttgGtctggtcaagtgttgaagac	10	12	10	9	0	3	3	1	1	2	2	4	3	3	3	2	2	2	1	2	2	5	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:207760880G>A	uc001hfy.2	+	26	4470	c.4330G>A	c.(4330-4332)GTC>ATC	p.V1444I	CR1_uc009xcl.1_Missense_Mutation_p.V994I|CR1_uc001hfx.2_Missense_Mutation_p.V1894I	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1444	Sushi 22.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						AGAAAACTTGGTCTGGTCAAG	0.388													45	81					0	0	0	0	A	207760880	A	A	207760880	3	1	211	1	0	0	0	0	1	0	0	0	3855	1261	44	4	5814	4	CR1	1	207760880	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	24242473	207760880	41489741	13	38402											
CD34	947	broad.mit.edu	37	chr1	208072364	208072364	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atgatgtatagggtttagtgGgagatgttgcaaggctagtg	10	13	16	2	0	0	2	0	1	0	1	0	3	0	2	0	3	1	5	0	3	5	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:208072364G>A	uc001hgw.1	-	3	728	c.470C>T	c.(469-471)CCC>CTC	p.P157L	CD34_uc001hgx.1_Missense_Mutation_p.P157L|CD34_uc010psj.1_Intron	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	157	Extracellular (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						GGGTTTAGTGGGAGATGTTGC	0.468													78	185					0	0	0	0	A	208072364	A	A	208072364	3	1	211	1	0	0	0	0	1	0	0	0	3021	1232	43	4	730	4	CD34	1	208072364	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	311484	208072364	41178257	14	38403											
SLC30A1	7779	broad.mit.edu	37	chr1	211751730	211751730	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcccccattacctcggctcgGatccagccgaacgtgttctt	6	10	9	16	4	1	0	0	0	1	0	4	2	2	1	5	2	3	2	5	2	2	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:211751730G>A	uc001hio.1	-	1	370	c.225C>T	c.(223-225)ATC>ATT	p.I75I		NM_021194	NP_067017	Q9Y6M5	ZNT1_HUMAN	solute carrier family 30 (zinc transporter),	75	Cytoplasmic (Potential).				cadmium ion transmembrane transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|negative regulation of calcium ion import|negative regulation of neurotransmitter secretion|negative regulation of zinc ion import	integral to membrane|T-tubule	calcium channel inhibitor activity|zinc ion transmembrane transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(81;0.00535)|GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.0604)|Epithelial(68;0.0978)		CCTCGGCTCGGATCCAGCCGA	0.662													16	20					0	0	0	0	A	211751730	A	A	211751730	2	1	211	1	0	0	0	0	0	0	0	1	14617	1164	41	2		2	SLC30A1	1	211751730	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	3679366	211751730	37498891	15	38404											
AIDA	64853	broad.mit.edu	37	chr1	222843263	222843263	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcaaagtttgatgtagaTgaagataaagtggtttcttg	12	15	12	2	0	1	4	0	2	1	2	1	4	1	4	0	1	1	4	0	1	5	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:222843263T>C	uc001hnn.2	-	10	1098	c.893A>G	c.(892-894)CAT>CGT	p.H298R	AIDA_uc001hno.2_RNA|AIDA_uc010pus.1_Missense_Mutation_p.H274R	NM_022831	NP_073742	Q96BJ3	AIDA_HUMAN	axin interactor, dorsalization associated	298					dorsal/ventral pattern formation|negative regulation of JNK cascade|negative regulation of JUN kinase activity|regulation of protein homodimerization activity						0						TTGATGTAGATGAAGATAAAG	0.353													18	31					0	0	0	0	C	222843263	C	C	222843263	3	2	211	1	0	0	0	0	1	0	0	0	423	1464	51	5	31	5	AIDA	1	222843263	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	11091533	222843263	26407358	16	38405											
ZNF678	339500	broad.mit.edu	37	chr1	227842404	227842404	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaattcatactggagagaaAccctacaaatgtgacgaatg	17	8	9	7	1	1	3	1	1	0	2	1	6	1	4	1	1	3	0	1	1	6	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:227842404A>G	uc001hqw.1	+	4	798	c.453A>G	c.(451-453)AAA>AAG	p.K151K	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	206					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				CTGGAGAGAAACCCTACAAAT	0.353													26	78					0	0	0	0	G	227842404	G	G	227842404	2	3	211	1	0	0	0	0	0	0	0	1	18152	40	2	5		5	ZNF678	1	227842404	Silent	SNP	A	TCGA-CV-6956-01A-21D-2012-08	4999141	227842404	21408217	17	38406											
RYR2	6262	broad.mit.edu	37	chr1	237802492	237802492	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcaccaaatagcggatccaGtaaaacactgtaggtctaat	15	9	7	10	1	2	0	1	0	1	0	3	1	3	1	2	2	2	2	2	2	6	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:237802492G>T	uc001hyl.1	+	46	7226	c.7106G>T	c.(7105-7107)AGT>ATT	p.S2369I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2369	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCGGATCCAGTAAAACACTG	0.418													7	20					2.0095e-06	2.19068e-06	1	0	T	237802492	T	T	237802492	3	4	211	1	0	0	0	0	1	0	0	0	13834	1029	36	4	7288	4	RYR2	1	237802492	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	9960088	237802492	11448129	18	38407											
OR2T3	343173	broad.mit.edu	37	chr1	248636651	248636651	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggggaaactgagccagtCatgtgctcagggaatcagac	12	6	14	9	0	3	2	3	1	0	1	3	4	3	4	1	3	3	1	1	3	2	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr1:248636651C>T	uc001iel.1	+							NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGAGCCAGTCATGTGCTCAG	0.443													15	81					0	0	0	0	T	248636651	T	T	248636651	1	4	211	0	1	0	0	0	0	0	0	0	11077	841	29	2		2	OR2T3	1	248636651	5'Flank	SNP	C	TCGA-CV-6956-01A-21D-2012-08	10834159	248636651	613970	19	38408											
OTOF	9381	broad.mit.edu	37	chr2	26702480	26702480	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccttccggggccgaggccGctggggccgggacaggccat	4	5	17	15	4	0	0	0	0	0	0	2	2	2	1	6	7	0	1	6	7	0	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:26702480G>T	uc002rhk.2	-	17	2081	c.1954C>A	c.(1954-1956)CGG>AGG	p.R652R	OTOF_uc002rhh.2_5'Flank|OTOF_uc002rhi.2_5'Flank|OTOF_uc002rhj.2_5'Flank	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	652	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCGAGGCCGCTGGGGCCGG	0.642													22	38					2.44723e-14	2.89317e-14	1	0	T	26702480	T	T	26702480	2	4	211	1	0	0	0	0	0	0	0	1	11357	1086	38	3		3	OTOF	2	26702480	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08		26702480	216496893	20	38409											
GPR75	10936	broad.mit.edu	37	chr2	54080317	54080317	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctgaagtgctgtcatatTcctgcactaagtcattagtg	9	14	10	8	0	2	1	2	1	0	0	3	1	3	1	1	1	2	3	1	1	4	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:54080317T>C	uc002rxo.3	-	2	1848	c.1577A>G	c.(1576-1578)GAA>GGA	p.E526G	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	526	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GCTGTCATATTCCTGCACTAA	0.408													29	70					0	0	0	0	C	54080317	C	C	54080317	3	2	211	1	0	0	0	0	1	0	0	0	6746	1783	62	5	49	5	GPR75	2	54080317	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	27377837	54080317	189119056	21	38410											
AFTPH	54812	broad.mit.edu	37	chr2	64780007	64780007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttttgaagagtcttcagagCactttccacattttagtgaa	11	15	7	8	0	2	4	1	2	1	2	3	4	3	4	1	0	1	1	1	0	3	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:64780007C>T	uc002sdc.2	+	1	1431	c.1399C>T	c.(1399-1401)CAC>TAC	p.H467Y	AFTPH_uc002scz.2_Missense_Mutation_p.H467Y|AFTPH_uc002sda.2_Missense_Mutation_p.H467Y|AFTPH_uc002sdb.2_Missense_Mutation_p.H467Y	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	467					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						GTCTTCAGAGCACTTTCCACA	0.413													33	58					0	0	0	0	T	64780007	T	T	64780007	3	4	211	1	0	0	0	0	1	0	0	0	364	710	25	4	1401	4	AFTPH	2	64780007	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	10699690	64780007	178419366	22	38411											
WDR54	84058	broad.mit.edu	37	chr2	74652827	74652827	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccggagattcagcagtgtgtGagaagagcagccttcctttg	9	10	13	9	1	1	3	1	1	0	3	2	5	2	3	3	1	3	2	3	1	1	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:74652827G>C	uc002slb.2	+	10	1064	c.1004G>C	c.(1003-1005)TGA>TCA	p.*335S		NM_032118	NP_115494	Q9H977	WDR54_HUMAN	WD repeat domain 54	335											0						AGCAGTGTGTGAGAAGAGCAG	0.507													71	98					0	0	0	0	C	74652827	C	C	74652827	4	2	211	1	0	0	0	0	0	0	0	0	17374	1285	45	2	1038	2	WDR54	2	74652827	Nonstop_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	9872820	74652827	168546546	23	38412											
MYO7B	4648	broad.mit.edu	37	chr2	128384629	128384629	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcccgcctgcagtggccgcTgctcttctcccggctcttcg	1	10	11	19	5	3	0	0	0	3	0	5	0	3	0	4	2	2	4	4	2	0	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:128384629T>A	uc002top.2	+	31	4270	c.4217T>A	c.(4216-4218)CTG>CAG	p.L1406Q	MYO7B_uc002toq.1_Missense_Mutation_p.L259Q|MYO7B_uc002tor.1_Missense_Mutation_p.L259Q	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1406	FERM 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CAGTGGCCGCTGCTCTTCTCC	0.637													7	12					0	0	0	0	A	128384629	A	A	128384629	3	1	211	1	0	0	0	0	1	0	0	0	10136	1580	55	5	4335	5	MYO7B	2	128384629	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	53731802	128384629	114814744	24	38413											
RAB3GAP1	22930	broad.mit.edu	37	chr2	135851202	135851202	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagatgttgttccacaatctAtgcaagatttgctgggtatg	10	15	10	6	0	1	2	0	0	1	2	2	2	2	2	1	1	2	5	1	1	5	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:135851202A>T	uc002tuj.2	+	5	326	c.301A>T	c.(301-303)ATG>TTG	p.M101L	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.M101L|RAB3GAP1_uc010fng.2_5'UTR|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	101						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		TCCACAATCTATGCAAGATTT	0.338													21	39					0	0	0	0	T	135851202	T	T	135851202	3	4	211	1	0	0	0	0	1	0	0	0	13000	449	16	5	319	5	RAB3GAP1	2	135851202	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08	7466573	135851202	107348171	25	38414											
NEB	4703	broad.mit.edu	37	chr2	152397296	152397296	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gatggggtctctctttggtgGcaagttcaacatacagatac	10	12	11	8	0	3	1	1	0	2	1	4	2	3	1	0	4	3	2	0	4	4	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:152397296G>T	uc010fnx.2	-	109	15790	c.15599C>A	c.(15598-15600)GCC>GAC	p.A5200D	NEB_uc002txr.2_Missense_Mutation_p.A1623D	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5200	Nebulin 141.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTCTTTGGTGGCAAGTTCAAC	0.413													26	45					2.79863e-10	3.20878e-10	1	0	T	152397296	T	T	152397296	3	4	211	1	0	0	0	0	1	0	0	0	10356	1203	42	4	5168	4	NEB	2	152397296	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	16546094	152397296	90802077	26	38415											
SCN3A	6328	broad.mit.edu	37	chr2	166003416	166003416	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcttcttttcttccttcGgttcctccattctttagcac	3	20	4	14	1	4	0	0	0	4	0	8	0	7	0	3	1	1	2	3	1	1	9			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:166003416G>A	uc002ucx.2	-	12	1996	c.1504C>T	c.(1504-1506)CGA>TGA	p.R502*	SCN3A_uc002ucy.2_Nonsense_Mutation_p.R502*|SCN3A_uc002ucz.2_Nonsense_Mutation_p.R502*|SCN3A_uc002uda.1_Nonsense_Mutation_p.R371*|SCN3A_uc002udb.1_Nonsense_Mutation_p.R371*	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	502						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTCTTCCTTCGGTTCCTCCAT	0.428													51	96					0	0	0	0	A	166003416	A	A	166003416	4	1	211	1	0	0	0	0	0	1	0	0	13983	1124	39	1	4566	1	SCN3A	2	166003416	Nonsense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	13606120	166003416	77195957	27	38416											
TTN	7273	broad.mit.edu	37	chr2	179457367	179457367	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcttgccatgttggcatCaagaatcaactcagggggtt	9	13	10	9	0	4	1	3	0	1	1	5	1	4	1	1	3	2	3	1	3	3	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:179457367C>A	uc010zfg.1	-	250	51885	c.51661G>T	c.(51661-51663)GAT>TAT	p.D17221Y	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D10916Y|TTN_uc010zfi.1_Missense_Mutation_p.D10849Y|TTN_uc010zfj.1_Missense_Mutation_p.D10724Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18148							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTTGGCATCAAGAATCAAC	0.363													35	51					7.65355e-07	8.48269e-07	1	0	A	179457367	A	A	179457367	3	1	211	1	0	0	0	0	1	0	0	0	16803	826	29	2	48862	2	TTN	2	179457367	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	13453951	179457367	63742006	28	38417											
GULP1	51454	broad.mit.edu	37	chr2	189458684	189458684	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaggggttcaaaatgggActaactcttgaaggcacagt	13	8	13	7	0	2	1	1	1	1	0	2	3	2	3	0	5	1	2	0	5	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:189458684A>T	uc010fru.2	+	12	1322	c.861A>T	c.(859-861)GGA>GGT	p.G287G	GULP1_uc002uqd.2_Missense_Mutation_p.D291V|GULP1_uc010zfw.1_Silent_p.G184G|GULP1_uc002uqf.2_Silent_p.G287G|GULP1_uc002uqg.2_Silent_p.G287G|GULP1_uc002uqh.1_3'UTR	NM_016315	NP_057399	Q9UBP9	GULP1_HUMAN	GULP, engulfment adaptor PTB domain containing	287					apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)			TCAAAATGGGACTAACTCTTG	0.338													9	26					0	0	0	0	T	189458684	T	T	189458684	2	4	211	1	0	0	0	0	0	0	0	1	6940	262	10	5		5	GULP1	2	189458684	Silent	SNP	A	TCGA-CV-6956-01A-21D-2012-08	10001317	189458684	53740689	29	38418											
CPS1	1373	broad.mit.edu	37	chr2	211473156	211473156	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agaaattaagaacgtcgtatCcgggaagacatcagcctgtt	14	9	10	8	3	1	3	1	0	0	3	3	4	2	4	2	1	2	2	2	1	5	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:211473156C>T	uc002vee.3	+	19	2396	c.2264C>T	c.(2263-2265)TCC>TTC	p.S755F	CPS1_uc010fur.2_Missense_Mutation_p.S761F|CPS1_uc010fus.2_Missense_Mutation_p.S304F	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	755					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AACGTCGTATCCGGGAAGACA	0.423													27	47					0	0	0	0	T	211473156	T	T	211473156	3	4	211	1	0	0	0	0	1	0	0	0	3838	855	30	2	2360	2	CPS1	2	211473156	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	22014472	211473156	31726217	30	38419											
MARCH4	57574	broad.mit.edu	37	chr2	217124378	217124378	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtttaaagatgcggtacaccGagggtccttcatggatgatg	10	11	13	7	2	1	2	1	1	0	1	2	4	2	3	2	3	2	2	2	3	3	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:217124378G>A	uc002vgb.2	-	4	2657	c.890C>T	c.(889-891)TCG>TTG	p.S297L		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	297						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GCGGTACACCGAGGGTCCTTC	0.537													23	25					0	0	0	0	A	217124378	A	A	217124378	3	1	211	1	0	0	0	0	1	0	0	0	9356	1059	37	1	346	1	MARCH4	2	217124378	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	5651222	217124378	26074995	31	38420											
COL6A3	1293	broad.mit.edu	37	chr2	238287849	238287849	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttggctgatccatccaaaaGaaagatgatatcccttttgt	12	13	8	8	0	0	4	0	2	0	2	3	4	3	4	3	1	0	2	3	1	4	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:238287849G>C	uc002vwl.2	-	6	2212	c.1927C>G	c.(1927-1929)CTT>GTT	p.L643V	COL6A3_uc002vwo.2_Missense_Mutation_p.L437V|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Missense_Mutation_p.L437V|COL6A3_uc002vwr.2_Missense_Mutation_p.L236V|COL6A3_uc010znk.1_Intron	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	643	VWFA 4.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCATCCAAAAGAAAGATGATA	0.388													11	24					0	0	0	0	C	238287849	C	C	238287849	3	2	211	1	0	0	0	0	1	0	0	0	3716	942	33	2	7809	2	COL6A3	2	238287849	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	21163471	238287849	4911524	32	38421											
MYEOV2	150678	broad.mit.edu	37	chr2	241069334	241069334	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgcacttcttacctcttcCgacaccacaggccgctctgc	7	10	7	17	2	3	0	0	0	3	0	4	2	4	0	4	1	3	2	4	1	1	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:241069334C>T	uc002vyu.1	-	4	375	c.375G>A	c.(373-375)TCG>TCA	p.S125S		NM_138336	NP_612209	Q8WXC6	MYOV2_HUMAN	hypothetical protein LOC150678 isoform 1	Error:Variant_position_missing_in_Q8WXC6_after_alignment											0		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		TTACCTCTTCCGACACCACAG	0.617													34	65					0	0	0	0	T	241069334	T	T	241069334	2	4	211	1	0	0	0	0	0	0	0	1	10079	639	23	1		1	MYEOV2	2	241069334	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	2781485	241069334	2130039	33	38422											
ING5	84289	broad.mit.edu	37	chr2	242650884	242650884	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagtgattttgaaagctcCggagggcgagggttaaaaag	12	8	16	5	2	0	2	0	2	0	0	1	4	1	3	1	4	1	3	1	4	4	3	rs142180451	byFrequency	TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr2:242650884C>T	uc002wcd.2	+	4	394	c.369C>T	c.(367-369)TCC>TCT	p.S123S	ING5_uc002wcc.1_Silent_p.S123S	NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	123					DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		TTGAAAGCTCCGGAGGGCGAG	0.393													44	94					0	0	0	0	T	242650884	T	T	242650884	2	4	211	1	0	0	0	0	0	0	0	1	7778	639	23	1		1	ING5	2	242650884	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	1581550	242650884	548489	34	38423											
PLCL2	23228	broad.mit.edu	37	chr3	17052859	17052859	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caacaaacgttttcttgctaGggtttttcccagtccaatga	10	14	7	10	1	1	1	0	1	1	0	3	1	3	1	2	1	3	3	2	1	4	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:17052859G>A	uc011awc.1	+	5	2102	c.1997G>A	c.(1996-1998)AGG>AAG	p.R666K	PLCL2_uc011awd.1_Missense_Mutation_p.R548K	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	674	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						TTTCTTGCTAGGGTTTTTCCC	0.398													16	23					0	0	0	0	A	17052859	A	A	17052859	3	1	211	1	0	0	0	0	1	0	0	0	12095	1000	35	4	2021	4	PLCL2	3	17052859	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08		17052859	180969571	35	38424											
TOP2B	7155	broad.mit.edu	37	chr3	25665146	25665146	+	Frame_Shift_Del	DEL	T	-	-																															aaccatgggaattataggaaTataccactcaggctctacac																										TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:25665146delT	uc011awn.1	-	21	2630	c.2587delA	c.(2587-2589)ATTfs	p.I863fs	TOP2B_uc003cdj.2_Frame_Shift_Del_p.I858fs	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	863					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						ATTATAGGAATATACCACTCA	0.398													---	---	---								-	25665146	-	-	25665146	7	5	211	1	0	1	0	1	0	0	0	0	16433	1406	49	0	2357	0	TOP2B	3	25665146	Frame_Shift_Del	DEL	T	TCGA-CV-6956-01A-21D-2012-08	8612287	25665146	172357284	36	38425											
EPHA3	2042	broad.mit.edu	37	chr3	89456492	89456492	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagtagcaattattctcctCactgttgtcatctatgtttt	8	18	6	9	0	4	0	2	0	2	0	5	0	4	0	1	0	1	5	1	0	4	7			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:89456492C>G	uc003dqy.2	+	8	1893	c.1668C>G	c.(1666-1668)CTC>CTG	p.L556L	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	556	Helical; (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TTATTCTCCTCACTGTTGTCA	0.408										TSP Lung(6;0.00050)			10	13					0	0	0	0	G	89456492	G	G	89456492	2	3	211	1	0	0	0	0	0	0	0	1	5192	813	29	2		2	EPHA3	3	89456492	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	63791346	89456492	108565938	37	38426											
EPHA6	285220	broad.mit.edu	37	chr3	97439174	97439174	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaaaattctcctcagcaagcGatgcatggagctatggcatt	12	10	10	9	1	2	0	1	0	1	0	3	3	2	1	1	2	4	4	1	2	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:97439174G>C	uc010how.1	+	15	2897	c.2854G>C	c.(2854-2856)GAT>CAT	p.D952H	EPHA6_uc003drt.2_Missense_Mutation_p.D344H|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	857	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CTCAGCAAGCGATGCATGGAG	0.463													45	60					0	0	0	0	C	97439174	C	C	97439174	3	2	211	1	0	0	0	0	1	0	0	0	5195	1058	37	3	3029	3	EPHA6	3	97439174	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	7982682	97439174	100583256	38	38427											
KALRN	8997	broad.mit.edu	37	chr3	124369736	124369736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggatggccccacccacacctCctaaaaacccagaagaagaa	16	3	7	15	0	0	3	0	0	0	3	1	4	1	4	6	2	1	0	6	2	6	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:124369736C>T	uc003ehg.2	+	38	5870	c.5743C>T	c.(5743-5745)CCT>TCT	p.P1915S	KALRN_uc003ehi.2_Missense_Mutation_p.P256S|KALRN_uc003ehk.2_Missense_Mutation_p.P218S|KALRN_uc011bjz.1_Missense_Mutation_p.P7S|KALRN_uc003ehj.2_Missense_Mutation_p.P186S	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1914					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ACCCACACCTCCTAAAAACCC	0.542													23	55					0	0	0	0	T	124369736	T	T	124369736	3	4	211	1	0	0	0	0	1	0	0	0	8014	855	30	2	6049	2	KALRN	3	124369736	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	26930562	124369736	73652694	39	38428											
STAG1	10274	broad.mit.edu	37	chr3	136141433	136141433	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccacaacaaacttaatcTgttttaataaagcatccaga	16	12	3	10	0	2	1	0	0	2	1	4	1	3	1	2	0	3	2	2	0	6	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:136141433T>C	uc003era.1	-	19	2148	c.1856A>G	c.(1855-1857)CAG>CGG	p.Q619R	STAG1_uc003erb.1_Missense_Mutation_p.Q619R|STAG1_uc003erc.1_Missense_Mutation_p.Q393R|STAG1_uc010hua.1_Missense_Mutation_p.Q482R	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	619					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						AAACTTAATCTGTTTTAATAA	0.308													21	52					0	0	0	0	C	136141433	C	C	136141433	3	2	211	1	0	0	0	0	1	0	0	0	15308	1580	55	5	1984	5	STAG1	3	136141433	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	11771697	136141433	61880997	40	38429											
CLSTN2	64084	broad.mit.edu	37	chr3	140281753	140281753	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggcgtttccggattaagtgCtcagaactcaatgggcgcta	9	10	12	10	4	2	1	2	0	0	1	3	2	3	2	1	3	2	3	1	3	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:140281753C>A	uc003etn.2	+	14	2503	c.2313C>A	c.(2311-2313)TGC>TGA	p.C771*		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	771	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GGATTAAGTGCTCAGAACTCA	0.562										HNSCC(16;0.037)			10	38					0.000673444	0.000710858	1	0	A	140281753	A	A	140281753	4	1	211	1	0	0	0	0	0	1	0	0	3577	805	28	4	2367	4	CLSTN2	3	140281753	Nonsense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	4140320	140281753	57740677	41	38430											
PIK3CA	5290	broad.mit.edu	37	chr3	178916946	178916946	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaggcaaccgtgaagaaaaGatcctcaatcgagaaattgg	16	7	11	7	2	1	4	1	1	0	3	3	5	2	4	2	2	1	2	2	2	7	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:178916946G>C	uc003fjk.2	+	2	490	c.333G>C	c.(331-333)AAG>AAC	p.K111N		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	111					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.K111N(10)|p.K111E(7)|p.K111R(1)|p.K111del(1)|p.K111_I112>N(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GTGAAGAAAAGATCCTCAATC	0.328		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	42					0	0	0	0	C	178916946	C	C	178916946	3	2	211	1	0	0	0	0	1	0	0	0	11968	933	33	2	335	2	PIK3CA	3	178916946	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	38635193	178916946	19105484	42	38431											
MCF2L2	23101	broad.mit.edu	37	chr3	182897459	182897459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acaggtttcgtgactgtcgtCcgactggaaaaggcccgcga	9	8	13	11	5	0	1	0	1	0	0	3	4	1	2	2	3	0	1	2	3	2	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:182897459C>T	uc003fli.1	-	29	3217	c.3127G>A	c.(3127-3129)GAC>AAC	p.D1043N		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	1043					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TGACTGTCGTCCGACTGGAAA	0.587													85	82					0	0	0	0	T	182897459	T	T	182897459	3	4	211	1	0	0	0	0	1	0	0	0	9433	855	30	2	225	2	MCF2L2	3	182897459	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	3980513	182897459	15124971	43	38432											
RFC4	5984	broad.mit.edu	37	chr3	186518927	186518927	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgctccttctaaagatttTttcagcactgcaaccacttc	9	15	4	13	0	3	1	1	0	2	1	5	1	4	1	2	0	4	3	2	0	3	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:186518927T>G	uc003fqz.2	-	3	412	c.189A>C	c.(187-189)AAA>AAC	p.K63N	RFC4_uc011bsc.1_Missense_Mutation_p.K63N|RFC4_uc011bsd.1_Missense_Mutation_p.K63N	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	63					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		CTAAAGATTTTTTCAGCACTG	0.378													24	106					0	0	0	0	G	186518927	G	G	186518927	3	3	211	1	0	0	0	0	1	0	0	0	13312	1838	64	5	938	5	RFC4	3	186518927	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	3621468	186518927	11503503	44	38433											
MFI2	4241	broad.mit.edu	37	chr3	196735690	196735690	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acccgggtacctgaaggcgcCgcggtagccgtaataccgct	8	6	13	14	6	0	1	0	1	0	0	0	1	0	1	5	3	3	4	5	3	5	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr3:196735690C>T	uc003fxk.3	-	12	1785	c.1672G>A	c.(1672-1674)GGC>AGC	p.G558S		NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	558	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		CTGAAGGCGCCGCGGTAGCCG	0.672													26	60					0	0	0	0	T	196735690	T	T	196735690	3	4	211	1	0	0	0	0	1	0	0	0	9575	652	23	1	564	1	MFI2	3	196735690	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	10216763	196735690	1286740	45	38434											
DRD5	1816	broad.mit.edu	37	chr4	9784899	9784899	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctacatccacatgatgcccAacgccgttacccccggcaac	10	6	6	19	3	0	1	0	1	0	0	1	1	1	1	6	1	5	2	6	1	4	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr4:9784899A>C	uc003gmb.3	+	1	1642	c.1246A>C	c.(1246-1248)AAC>CAC	p.N416H		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	416	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CATGATGCCCAACGCCGTTAC	0.567													19	48					0	0	0	0	C	9784899	C	C	9784899	3	2	211	1	0	0	0	0	1	0	0	0	4782	130	5	5	1248	5	DRD5	4	9784899	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08		9784899	181369377	46	38435											
BOD1L	259282	broad.mit.edu	37	chr4	13610154	13610154	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccagataaaatatgtacCttgaatctttttttctcttt	11	19	4	7	0	2	3	0	2	2	1	3	3	2	3	2	0	1	1	2	0	5	8			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	e0a52d9d-41f2-46d3-8c62-df1241806397	g.chr4:13610154C>T	uc003gmz.1	-	8	1859	c.1742G>A	c.(1741-1743)AGG>AAG	p.R581K	BOD1L_uc010idr.1_5'UTR	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	581	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						AAATATGTACCTTGAATCTTT	0.363													3	4					0	0	0	0	T	13610154	T	T	13610154	3	4	211	1	0	0	0	0	1	0	0	0	1486	695	24	4	7489	4	BOD1L	4	13610154	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	3825255	13610154	177544122	47	38436											
LCORL	254251	broad.mit.edu	37	chr4	17910776	17910776	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctaaggggccttcctgcTcttcctgaagggagttttct	5	14	12	10	0	3	1	0	1	3	0	5	2	5	2	3	4	1	2	3	4	2	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr4:17910776T>A	uc003gpq.2	-	5	634	c.623A>T	c.(622-624)GAG>GTG	p.E208V	LCORL_uc011bxk.1_Missense_Mutation_p.E121V	NM_153686	NP_710153	Q8N3X6	LCORL_HUMAN	ligand dependent nuclear receptor	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						GCCTTCCTGCTCTTCCTGAAG	0.348													28	42					0	0	0	0	A	17910776	A	A	17910776	3	1	211	1	0	0	0	0	1	0	0	0	8730	1551	54	5	1382	5	LCORL	4	17910776	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	4300622	17910776	173243500	48	38437											
SLIT2	9353	broad.mit.edu	37	chr4	20619185	20619185	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacccatgccaggcgatcaaGtgcaagcatgggaagtgcag	13	5	13	10	1	1	0	1	0	0	0	1	2	1	1	2	2	5	3	2	2	4	0	rs111791287		TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr4:20619185G>T	uc003gpr.1	+	36	4464	c.4260G>T	c.(4258-4260)AAG>AAT	p.K1420N	SLIT2_uc003gps.1_Missense_Mutation_p.K1412N	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1420					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AGGCGATCAAGTGCAAGCATG	0.557													13	15					5.50884e-06	5.95671e-06	1	0	T	20619185	T	T	20619185	3	4	211	1	0	0	0	0	1	0	0	0	14804	1020	36	4	4402	4	SLIT2	4	20619185	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	2708409	20619185	170535091	49	38438											
RCHY1	25898	broad.mit.edu	37	chr4	76407873	76407873	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccattacagtcattgcagaGaatctgaaaagagattaatt	16	12	7	6	0	2	3	1	1	1	2	3	5	3	3	1	0	2	1	1	0	5	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr4:76407873G>C	uc003hik.2	-	9	793	c.661C>G	c.(661-663)CTC>GTC	p.L221V	RCHY1_uc010iio.2_Missense_Mutation_p.L117V|RCHY1_uc003hij.2_3'UTR|RCHY1_uc003hil.2_Missense_Mutation_p.L212V|RCHY1_uc010iip.2_3'UTR|RCHY1_uc010iiq.2_RNA|RCHY1_uc010iir.2_Missense_Mutation_p.L181V	NM_015436	NP_056251	Q96PM5	ZN363_HUMAN	ring finger and CHY zinc finger domain	221					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein autoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nuclear speck|ubiquitin ligase complex	electron carrier activity|p53 binding|protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TCATTGCAGAGAATCTGAAAA	0.318													7	17					0	0	0	0	C	76407873	C	C	76407873	3	2	211	1	0	0	0	0	1	0	0	0	13242	942	33	2	128	2	RCHY1	4	76407873	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	55788688	76407873	114746403	50	38439											
ENPEP	2028	broad.mit.edu	37	chr4	111398004	111398004	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccaggatcacccggctccCggagctgaagaggccctctg	8	5	13	15	2	2	2	1	1	1	1	3	5	3	4	4	4	1	2	4	4	1	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr4:111398004C>A	uc003iab.3	+	1	776	c.434C>A	c.(433-435)CCG>CAG	p.P145Q		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	145	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ACCCGGCTCCCGGAGCTGAAG	0.627													51	108					2.52991e-16	3.05889e-16	1	0	A	111398004	A	A	111398004	3	1	211	1	0	0	0	0	1	0	0	0	5152	652	23	3	436	3	ENPEP	4	111398004	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	34990131	111398004	79756272	51	38440											
SEC24D	9871	broad.mit.edu	37	chr4	119649746	119649746	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatggcctcttttgttggatAatacccattatcattctgag	9	17	7	8	0	3	1	1	1	2	0	3	2	3	2	2	2	1	1	2	2	4	8			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr4:119649746A>T	uc003ici.3	-	22	3200	c.2928T>A	c.(2926-2928)ATT>ATA	p.I976I	SEC24D_uc003ich.3_RNA|SEC24D_uc003icj.3_Silent_p.I977I	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	976					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						TTTGTTGGATAATACCCATTA	0.308													7	25					0	0	0	0	T	119649746	T	T	119649746	2	4	211	1	0	0	0	0	0	0	0	1	14062	358	13	5		5	SEC24D	4	119649746	Silent	SNP	A	TCGA-CV-6956-01A-21D-2012-08	8251742	119649746	71504530	52	38441											
DCLK2	166614	broad.mit.edu	37	chr4	151168815	151168815	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgggaagctggagtttccGgccccctactgggataacat	8	9	13	11	1	0	0	0	0	0	0	1	3	1	3	3	4	3	3	3	4	3	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr4:151168815G>A	uc003ilm.3	+	13	1939	c.1839G>A	c.(1837-1839)CCG>CCA	p.P613P	DCLK2_uc003iln.3_Silent_p.P612P|DCLK2_uc003ilo.3_Silent_p.P630P|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	613	Protein kinase.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					TGGAGTTTCCGGCCCCCTACT	0.512													12	25					0	0	0	0	A	151168815	A	A	151168815	2	1	211	1	0	0	0	0	0	0	0	1	4309	1103	39	1		1	DCLK2	4	151168815	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	31519069	151168815	39985461	53	38442											
WDR17	116966	broad.mit.edu	37	chr4	177077229	177077229	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttttgccttctattgtaGtgggacaaagccctgtcaat	8	15	8	10	0	2	0	1	0	1	0	2	1	2	1	3	1	2	1	3	1	4	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr4:177077229G>T	uc003iuj.2	+	19	2689	c.2533_splice	c.e19-1	p.W845_splice	WDR17_uc003iuk.2_Splice_Site_p.W821_splice|WDR17_uc003ium.3_Splice_Site_p.W821_splice|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Splice_Site_p.W64_splice	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1											ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TTCTATTGTAGTGGGACAAAG	0.368													24	69					2.27525e-19	2.81497e-19	1	0	T	177077229	T	T	177077229	5	4	211	1	0	0	0	0	0	0	1	0	17345	1043	36	4	2602	4	WDR17	4	177077229	Splice_Site	SNP	G	TCGA-CV-6956-01A-21D-2012-08	25908414	177077229	14077047	54	38443											
FAT1	2195	broad.mit.edu	37	chr4	187538253	187538253	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcagttgccgtgatagtaAgaaggtaattgtcccttttt	10	15	9	7	1	1	2	1	1	0	1	2	2	2	2	2	1	1	3	2	1	4	7			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr4:187538253A>C	uc003izf.2	-	11	9169	c.8981T>G	c.(8980-8982)CTT>CGT	p.L2994R		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2994	Extracellular (Potential).|Cadherin 27.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CGTGATAGTAAGAAGGTAATT	0.413										HNSCC(5;0.00058)			13	23					0	0	0	0	C	187538253	C	C	187538253	3	2	211	1	0	0	0	0	1	0	0	0	5721	72	3	5	4853	5	FAT1	4	187538253	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08	10461024	187538253	3616023	55	38444											
DNAH5	1767	broad.mit.edu	37	chr5	13928288	13928288	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgatcaattctttcaatCtgggaaaaagaaaaaggcaa	18	10	8	5	0	4	2	2	1	2	1	4	3	4	3	0	2	0	2	0	2	7	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:13928288C>A	uc003jfd.2	-	3	235	c.193_splice	c.e3-1	p.I65_splice	DNAH5_uc003jfe.1_Splice_Site	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTCTTTCAATCTGGGAAAAAG	0.318									Kartagener_syndrome				23	72					3.5997e-14	4.23681e-14	1	0	A	13928288	A	A	13928288	5	1	211	1	0	0	0	0	0	0	1	0	4626	927	32	2	13990	2	DNAH5	5	13928288	Splice_Site	SNP	C	TCGA-CV-6956-01A-21D-2012-08		13928288	166986972	56	38445											
NIPBL	25836	broad.mit.edu	37	chr5	37048756	37048756	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacaagaagaagatacacgtAtgcagcaggcagatagagac	18	5	11	7	1	0	5	0	0	0	5	0	6	0	5	0	1	4	4	0	1	7	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:37048756A>G	uc003jkl.3	+	39	7241	c.6742A>G	c.(6742-6744)ATG>GTG	p.M2248V	NIPBL_uc003jkk.3_Missense_Mutation_p.M2248V|NIPBL_uc003jkn.2_5'Flank	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2248	HEAT 4.				brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AGATACACGTATGCAGCAGGC	0.269													9	24					0	0	0	0	G	37048756	G	G	37048756	3	3	211	1	0	0	0	0	1	0	0	0	10482	449	16	5	6892	5	NIPBL	5	37048756	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08	23120468	37048756	143866504	57	38446											
LIFR	3977	broad.mit.edu	37	chr5	38482196	38482196	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcagagcgatcttcaggaCgctcagctactggggaaatt	11	9	11	10	2	4	1	3	0	1	1	4	4	4	3	0	3	3	2	0	3	2	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:38482196C>T	uc010ive.1	-	20	3127	c.2795G>A	c.(2794-2796)CGT>CAT	p.R932H	LIFR_uc003jli.2_Missense_Mutation_p.R932H	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	932	Cytoplasmic (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					ATCTTCAGGACGCTCAGCTAC	0.433			T	PLAG1	salivary adenoma								29	188					0	0	0	0	T	38482196	T	T	38482196	3	4	211	1	0	0	0	0	1	0	0	0	8821	536	19	1	502	1	LIFR	5	38482196	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	1433440	38482196	142433064	58	38447											
GPR98	84059	broad.mit.edu	37	chr5	90106737	90106737	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttccattcatggaacattCagccttgggccatccattgt	8	14	8	11	0	2	0	2	0	0	0	4	1	4	1	4	2	2	1	4	2	1	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:90106737C>T	uc003kju.2	+	74	15756	c.15660C>T	c.(15658-15660)TTC>TTT	p.F5220F	GPR98_uc003kjt.2_Silent_p.F2926F|GPR98_uc003kjw.2_Silent_p.F881F	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5220	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGGAACATTCAGCCTTGGGC	0.463													28	32					0	0	0	0	T	90106737	T	T	90106737	2	4	211	1	0	0	0	0	0	0	0	1	6760	825	29	2		2	GPR98	5	90106737	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	51624541	90106737	90808523	59	38448											
NR2F1	7025	broad.mit.edu	37	chr5	92923999	92923999	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgccgttgctggccgccgcCggcctgcatgcctcgcccat	2	7	13	19	6	0	0	0	0	0	0	1	0	0	0	7	2	3	3	7	2	0	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:92923999C>T	uc003kkj.2	+	2	2527	c.840C>T	c.(838-840)GCC>GCT	p.A280A		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	280					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		TGGCCGCCGCCGGCCTGCATG	0.667													25	23					0	0	0	0	T	92923999	T	T	92923999	2	4	211	1	0	0	0	0	0	0	0	1	10681	639	23	1		1	NR2F1	5	92923999	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	2817262	92923999	87991261	60	38449											
SLC27A6	28965	broad.mit.edu	37	chr5	128302163	128302163	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggacacggtggctctgctGatgagcaatgagccggactt	8	8	16	9	2	1	3	0	3	1	0	1	5	1	5	1	5	3	3	1	5	1	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:128302163G>A	uc003kuy.2	+	2	729	c.333G>A	c.(331-333)CTG>CTA	p.L111L	SLC27A6_uc003kuz.2_Silent_p.L111L	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	111					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TGGCTCTGCTGATGAGCAATG	0.552													13	10					0	0	0	0	A	128302163	A	A	128302163	2	1	211	1	0	0	0	0	0	0	0	1	14594	1277	45	2		2	SLC27A6	5	128302163	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	35378164	128302163	52613097	61	38450											
PCDHGB4	8641	broad.mit.edu	37	chr5	140769259	140769259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggacacaacgcctggctgtCctaccacgtgctgcaggcta	9	7	11	14	2	0	0	0	0	0	0	1	1	1	1	3	3	4	4	3	3	3	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:140769259C>T	uc003lkc.1	+	1	1808	c.1808C>T	c.(1807-1809)TCC>TTC	p.S603F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.S603F	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	603	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCTGGCTGTCCTACCACGTG	0.662													28	21					0	0	0	0	T	140769259	T	T	140769259	3	4	211	1	0	0	0	0	1	0	0	0	11619	855	30	2	1810	2	PCDHGB4	5	140769259	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	12467096	140769259	40146001	62	38451											
PDGFRB	5159	broad.mit.edu	37	chr5	149503837	149503837	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttggtgcaggcccccaacaGgttgaccacgttcaggtggg	7	9	14	11	1	1	1	1	1	0	0	1	1	1	1	3	5	2	3	3	5	1	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:149503837G>T	uc003lro.2	-	14	2468	c.1999C>A	c.(1999-2001)CTG>ATG	p.L667M	PDGFRB_uc010jhd.2_Missense_Mutation_p.L506M	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	667	Cytoplasmic (Potential).|Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GCCCCCAACAGGTTGACCACG	0.632			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								19	22					4.35082e-09	4.88319e-09	1	0	T	149503837	T	T	149503837	3	4	211	1	0	0	0	0	1	0	0	0	11716	991	35	4	1361	4	PDGFRB	5	149503837	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	8734578	149503837	31411423	63	38452											
CDX1	1044	broad.mit.edu	37	chr5	149562339	149562339	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcttctcaggtaagactCggaccaaggacaagtaccgc	11	8	10	12	2	2	1	1	0	2	1	4	3	2	3	2	3	2	3	2	3	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:149562339C>A	uc003lrq.2	+	2	550	c.454C>A	c.(454-456)CGG>AGG	p.R152R		NM_001804	NP_001795	P47902	CDX1_HUMAN	caudal type homeobox 1	152						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGTAAGACTCGGACCAAGGA	0.557													97	73					9.72315e-31	1.21998e-30	1	0	A	149562339	A	A	149562339	2	1	211	1	0	0	0	0	0	0	0	1	3197	875	31	3		3	CDX1	5	149562339	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	58502	149562339	31352921	64	38453											
RNF44	22838	broad.mit.edu	37	chr5	175956543	175956543	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcgtctgctccgactgatGgctgtccgggttaaagcggt	6	10	14	11	4	1	1	0	1	1	0	3	2	3	1	2	3	3	3	2	3	2	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:175956543G>A	uc003mek.1	-	9	1642	c.1117C>T	c.(1117-1119)CAT>TAT	p.H373Y	RNF44_uc011dfo.1_Missense_Mutation_p.H281Y|RNF44_uc003mel.1_Missense_Mutation_p.H62Y	NM_014901	NP_055716	Q7L0R7	RNF44_HUMAN	ring finger protein 44	373							zinc ion binding				0	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCGACTGATGGCTGTCCGGG	0.647													22	25					0	0	0	0	A	175956543	A	A	175956543	3	1	211	1	0	0	0	0	1	0	0	0	13561	1348	47	4	193	4	RNF44	5	175956543	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	26394204	175956543	4958717	65	38454											
NSD1	64324	broad.mit.edu	37	chr5	176709523	176709523	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaagaagaatgcagagctCgaattcgctatgctcaagaa	16	8	10	7	2	1	5	1	1	0	4	3	6	1	5	0	0	3	4	0	0	7	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:176709523C>T	uc003mfr.3	+	19	6088	c.5950C>T	c.(5950-5952)CGA>TGA	p.R1984*	NSD1_uc003mft.3_Nonsense_Mutation_p.R1715*|NSD1_uc011dfx.1_Nonsense_Mutation_p.R1632*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1984	SET.		R -> Q (in SOTOSS; loss of enzyme activity).		negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ATGCAGAGCTCGAATTCGCTA	0.373			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			38	28					0	0	0	0	T	176709523	T	T	176709523	4	4	211	1	0	0	0	0	0	1	0	0	10723	876	31	1	6020	1	NSD1	5	176709523	Nonsense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	752980	176709523	4205737	66	38455											
GNB2L1	10399	broad.mit.edu	37	chr5	180666087	180666087	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttgcctccagaagcacagaGggatccatctggagagacag	12	6	12	11	0	1	3	0	0	1	3	3	6	3	5	3	2	2	1	3	2	1	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr5:180666087G>A	uc003mni.1	-	5	722	c.616C>T	c.(616-618)CTC>TTC	p.L206F	GNB2L1_uc003mnh.1_Missense_Mutation_p.L165F|GNB2L1_uc003mnk.1_Missense_Mutation_p.L128F|GNB2L1_uc003mnj.1_Missense_Mutation_p.L160F|GNB2L1_uc003mnl.1_5'UTR|GNB2L1_uc011dhk.1_Missense_Mutation_p.L206F|GNB2L1_uc010jls.2_3'UTR	NM_006098	NP_006089	P63244	GBLP_HUMAN	guanine nucleotide binding protein (G protein),	206	WD 5.				apoptosis|cell cycle|gastrulation|interspecies interaction between organisms|negative regulation of cell growth|negative regulation of phagocytosis|negative regulation of translation|negative regulation of Wnt receptor signaling pathway|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of gastrulation|positive regulation of GTPase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein homooligomerization|positive regulation of protein phosphorylation|regulation of cell cycle|regulation of cell division|regulation of establishment of cell polarity|regulation of protein localization|rhythmic process	cytoskeleton|dendrite|midbody|nucleus|perikaryon|perinuclear region of cytoplasm|phagocytic cup|small ribosomal subunit	ion channel inhibitor activity|protein kinase C binding|protein phosphatase binding|protein tyrosine kinase inhibitor activity|receptor tyrosine kinase binding|SH2 domain binding				0	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.101)|all cancers(165;0.11)		GAAGCACAGAGGGATCCATCT	0.522													47	45					0	0	0	0	A	180666087	A	A	180666087	3	1	211	1	0	0	0	0	1	0	0	0	6555	1000	35	4	353	4	GNB2L1	5	180666087	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	3956564	180666087	249173	67	38456											
HIST1H3H	8357	broad.mit.edu	37	chr6	27778004	27778004	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtacagtggctctccgcgaGattcgccgctaccagaagtc	8	8	12	13	4	1	2	0	0	1	2	4	3	1	2	3	2	2	3	3	2	3	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:27778004G>A	uc003njm.2	+	1	163	c.153G>A	c.(151-153)GAG>GAA	p.E51E	HIST1H2BL_uc003njl.2_5'Flank	NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h	51					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						CTCTCCGCGAGATTCGCCGCT	0.627													29	53					0	0	0	0	A	27778004	A	A	27778004	2	1	211	1	0	0	0	0	0	0	0	1	7201	933	33	2		2	HIST1H3H	6	27778004	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08		27778004	143337063	68	38457											
ABCF1	23	broad.mit.edu	37	chr6	30546284	30546284	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccctgattcaggatcagaGtgaggaagaggaggaggaag	14	5	17	5	0	2	4	2	2	0	2	2	9	2	9	1	5	1	0	1	5	2	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:30546284G>C	uc003nql.2	+	6	514	c.419G>C	c.(418-420)AGT>ACT	p.S140T	ABCF1_uc003nqk.2_Missense_Mutation_p.S141T|ABCF1_uc003nqm.2_Missense_Mutation_p.S140T|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	140				S->A: Reduces phosphorylation. Inhibits strongly phosphorylation by CK2; when associated with S-109. Does not inhibits interaction with EIF2; when associated with S-109. Does not inhibit association with ribosomes; when associated with S- 109. Reduces EIF2 interaction with ribosomes; when associated with S-109. Does not inhibit protein synthesis; when associated with A-109.	inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						CAGGATCAGAGTGAGGAAGAG	0.502													19	5					0	0	0	0	C	30546284	C	C	30546284	3	2	211	1	0	0	0	0	1	0	0	0	65	1029	36	4	441	4	ABCF1	6	30546284	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	2768280	30546284	140568783	69	38458											
BRD2	6046	broad.mit.edu	37	chr6	32947816	32947816	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcaaacccagaagagattGagattgattttgaaacactc	16	11	7	7	0	1	5	1	3	0	3	2	7	1	5	1	0	2	0	1	0	3	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:32947816G>T	uc003ocn.3	+	11	3754	c.2053G>T	c.(2053-2055)GAG>TAG	p.E685*	BRD2_uc003ocq.3_Nonsense_Mutation_p.E685*|BRD2_uc003ocp.3_Nonsense_Mutation_p.E565*|BRD2_uc010juh.2_Nonsense_Mutation_p.E720*	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	685	ET.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						AGAAGAGATTGAGATTGATTT	0.483													4	60					1.23904e-05	1.33435e-05	1	0	T	32947816	T	T	32947816	4	4	211	1	0	0	0	0	0	1	0	0	1507	1291	45	2	2091	2	BRD2	6	32947816	Nonsense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	2401532	32947816	138167251	70	38459											
DNAH8	1769	broad.mit.edu	37	chr6	38885712	38885712	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttttcagttgatgagtgcAacaggattcctgtggagcct	9	14	11	7	0	1	2	1	2	0	0	2	4	2	4	2	2	3	2	2	2	1	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:38885712A>G	uc003ooe.1	+	68	10269	c.9669A>G	c.(9667-9669)GCA>GCG	p.A3223A	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGATGAGTGCAACAGGATTCC	0.333													3	43					0	0	0	0	G	38885712	G	G	38885712	2	3	211	1	0	0	0	0	0	0	0	1	4629	117	5	5		5	DNAH8	6	38885712	Silent	SNP	A	TCGA-CV-6956-01A-21D-2012-08	5937896	38885712	132229355	71	38460											
DEFB114	245928	broad.mit.edu	37	chr6	49928037	49928037	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcttcttcatacaatttctCagtgcagcaaatttttcttg	10	18	4	9	0	5	0	2	0	4	0	6	0	5	0	0	0	3	2	0	0	3	7			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:49928037C>T	uc011dwp.1	-	2	178	c.178G>A	c.(178-180)GAG>AAG	p.E60K		NM_001037499	NP_001032588	Q30KQ6	DB114_HUMAN	beta-defensin 114 precursor	60					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					TACAATTTCTCAGTGCAGCAA	0.378													12	24					0	0	0	0	T	49928037	T	T	49928037	3	4	211	1	0	0	0	0	1	0	0	0	4424	835	29	2	34	2	DEFB114	6	49928037	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	11042325	49928037	121187030	72	38461											
EYS	346007	broad.mit.edu	37	chr6	66205124	66205124	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctattttagtgtttacaccCaaaaaccagcaatctctgta	13	14	4	10	0	2	0	0	0	2	0	3	0	2	0	2	0	3	3	2	0	7	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:66205124C>A	uc011dxu.1	-	4	718	c.180G>T	c.(178-180)TTG>TTT	p.L60F	EYS_uc003peq.2_Missense_Mutation_p.L60F|EYS_uc003per.1_Missense_Mutation_p.L60F|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	60					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TGTTTACACCCAAAAACCAGC	0.388													15	75					1.3612e-06	1.50241e-06	1	0	A	66205124	A	A	66205124	3	1	211	1	0	0	0	0	1	0	0	0	5357	593	21	4	9376	4	EYS	6	66205124	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	16277087	66205124	104909943	73	38462											
SYNCRIP	10492	broad.mit.edu	37	chr6	86324795	86324795	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaataaccggctctaccgcgGggaggagcagccccacgacc	10	3	13	15	4	1	0	0	0	1	0	1	4	1	2	5	4	4	2	5	4	3	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:86324795G>A	uc003pla.2	-	11	2092	c.1551C>T	c.(1549-1551)CCC>CCT	p.P517P	SYNCRIP_uc003pku.2_Silent_p.P517P|SYNCRIP_uc003pkw.2_Silent_p.P482P|SYNCRIP_uc003pky.2_Silent_p.P419P|SYNCRIP_uc003pkv.2_Silent_p.P517P|SYNCRIP_uc003pkx.2_Silent_p.P365P|SYNCRIP_uc003pkz.2_Silent_p.P482P	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	517	Interaction with APOBEC1.|8 X 3 AA repeats of R-G-G.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		CTCTACCGCGGGGAGGAGCAG	0.577													85	45					0	0	0	0	A	86324795	A	A	86324795	2	1	211	1	0	0	0	0	0	0	0	1	15510	1219	43	4		4	SYNCRIP	6	86324795	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	20119671	86324795	84790272	74	38463											
RFX6	222546	broad.mit.edu	37	chr6	117198535	117198535	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagactgctgtgtgcagctcCtgggcaagggcttgctagtc	7	10	14	10	0	0	1	0	0	0	1	2	1	1	1	1	2	4	6	1	2	3	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:117198535C>T	uc003pxm.2	+	1	160	c.97C>T	c.(97-99)CTG>TTG	p.L33L		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	33					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TGTGCAGCTCCTGGGCAAGGG	0.667													15	6					0	0	0	0	T	117198535	T	T	117198535	2	4	211	1	0	0	0	0	0	0	0	1	13332	680	24	4		4	RFX6	6	117198535	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	30873740	117198535	53916532	75	38464											
FAM184A	79632	broad.mit.edu	37	chr6	119345399	119345399	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	attcaacttgccttcataatCctcaattagtttcttccgtt	9	18	3	11	1	4	0	3	0	1	0	6	0	6	0	3	0	2	2	3	0	4	8			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:119345399C>G	uc003pyj.2	-	2	1087	c.739G>C	c.(739-741)GAT>CAT	p.D247H	FAM184A_uc003pyk.3_Missense_Mutation_p.D127H|FAM184A_uc003pyl.3_Missense_Mutation_p.D127H	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	247	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						CCTTCATAATCCTCAATTAGT	0.423													16	39					0	0	0	0	G	119345399	G	G	119345399	3	3	211	1	0	0	0	0	1	0	0	0	5539	855	30	2	2751	2	FAM184A	6	119345399	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	2146864	119345399	51769668	76	38465											
ULBP2	80328	broad.mit.edu	37	chr6	150263229	150263229	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcagcagccgccgctacCaagatccttctgtgcctccc	7	8	9	17	2	1	1	0	0	1	1	3	1	3	1	6	1	4	3	6	1	2	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:150263229C>A	uc003qno.2	+	1	94	c.21C>A	c.(19-21)ACC>ACA	p.T7T	ULBP2_uc011eeh.1_Silent_p.T7T|ULBP2_uc010kij.2_Silent_p.T7T	NM_025217	NP_079493	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2 precursor	7					antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		CCGCCGCTACCAAGATCCTTC	0.607													18	7					1.33834e-09	1.51488e-09	1	0	A	150263229	A	A	150263229	2	1	211	1	0	0	0	0	0	0	0	1	17041	581	21	4		4	ULBP2	6	150263229	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	30917830	150263229	20851838	77	38466											
PDE10A	10846	broad.mit.edu	37	chr6	165862443	165862443	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactctccaaggaaatacagTgcaaatccatcggcttttgt	12	11	7	11	1	1	0	0	0	1	0	4	1	2	1	2	2	2	2	2	2	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr6:165862443T>A	uc003qun.2	-	6	580	c.339A>T	c.(337-339)GCA>GCT	p.A113A	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Silent_p.A43A|PDE10A_uc003quo.2_Silent_p.A123A	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	113	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GGAAATACAGTGCAAATCCAT	0.368													23	38					0	0	0	0	A	165862443	A	A	165862443	2	1	211	1	0	0	0	0	0	0	0	1	11684	1683	59	5		5	PDE10A	6	165862443	Silent	SNP	T	TCGA-CV-6956-01A-21D-2012-08	15599214	165862443	5252624	78	38467											
ZFAND2A	90637	broad.mit.edu	37	chr7	1197827	1197827	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcttttctgaacaatgctTccccaaatcaggaaactcca	13	11	5	12	0	3	1	1	1	2	0	5	2	5	2	3	1	3	1	3	1	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr7:1197827T>G	uc003skc.2	-	2	323	c.22A>C	c.(22-24)AAG>CAG	p.K8Q	ZFAND2A_uc003skd.3_Missense_Mutation_p.K8Q|uc003skf.1_5'Flank	NM_182491	NP_872297	Q8N6M9	ZFN2A_HUMAN	zinc finger, AN1-type domain 2A	8	AN1-type 1.					cytoplasm|nucleus	zinc ion binding			ovary(1)	1		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.82e-15)		GAACAATGCTTCCCCAAATCA	0.408													48	230					0	0	0	0	G	1197827	G	G	1197827	3	3	211	1	0	0	0	0	1	0	0	0	17694	1792	62	5	431	5	ZFAND2A	7	1197827	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08		1197827	157940836	79	38468											
PKD1L1	168507	broad.mit.edu	37	chr7	47898336	47898336	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttcctccttcgagttttCttgctcagagacttcccaga	7	14	7	13	1	2	2	1	0	1	2	6	5	5	2	3	0	1	2	3	0	0	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr7:47898336C>G	uc003tny.1	-	27	4297	c.4297G>C	c.(4297-4299)GAA>CAA	p.E1433Q		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1433	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TTCGAGTTTTCTTGCTCAGAG	0.438													16	57					0	0	0	0	G	47898336	G	G	47898336	3	3	211	1	0	0	0	0	1	0	0	0	12019	922	32	2	4376	2	PKD1L1	7	47898336	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	46700509	47898336	111240327	80	38469											
ASB4	51666	broad.mit.edu	37	chr7	95157465	95157465	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatgctggaagctggcgcCgaagccaatctcatggatat	11	9	12	9	2	1	1	1	1	1	0	2	4	1	3	2	3	3	2	2	3	4	1	rs146416403	by1000genomes	TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr7:95157465C>A	uc011kij.1	+	3	828	c.828C>A	c.(826-828)GCC>GCA	p.A276A	ASB4_uc003unx.2_Silent_p.A276A	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	276	ANK 6.				intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			AAGCTGGCGCCGAAGCCAATC	0.577											OREG0018172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	35					8.10497e-08	9.0206e-08	1	0	A	95157465	A	A	95157465	2	1	211	1	0	0	0	0	0	0	0	1	1027	639	23	3		3	ASB4	7	95157465	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	47259129	95157465	63981198	81	38470											
CHRM2	1129	broad.mit.edu	37	chr7	136700385	136700385	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgacgatggcctggagcacaAcaaaatccagaatggcaaag	16	5	11	9	1	0	2	0	1	0	1	1	4	1	3	2	3	2	2	2	3	5	0	rs142006633	byFrequency	TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr7:136700385A>G	uc003vtf.1	+	4	1396	c.773A>G	c.(772-774)AAC>AGC	p.N258S	CHRM2_uc003vtg.1_Missense_Mutation_p.N258S|CHRM2_uc003vtj.1_Missense_Mutation_p.N258S|CHRM2_uc003vtk.1_Missense_Mutation_p.N258S|CHRM2_uc003vtl.1_Missense_Mutation_p.N258S|CHRM2_uc003vtm.1_Missense_Mutation_p.N258S|CHRM2_uc003vti.1_Missense_Mutation_p.N258S|CHRM2_uc003vto.1_Missense_Mutation_p.N258S|CHRM2_uc003vtn.1_Missense_Mutation_p.N258S|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	258	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CTGGAGCACAACAAAATCCAG	0.512													10	19					0	0	0	0	G	136700385	G	G	136700385	3	3	211	1	0	0	0	0	1	0	0	0	3392	43	2	5	775	5	CHRM2	7	136700385	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08	41542920	136700385	22438278	82	38471											
MGAM	8972	broad.mit.edu	37	chr7	141730195	141730195	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgatattgattatatggatGagagaagggacttcacttat	13	14	10	4	0	1	4	1	3	0	1	1	7	1	6	0	2	0	0	0	2	5	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr7:141730195G>A	uc003vwy.2	+	11	1309	c.1255G>A	c.(1255-1257)GAG>AAG	p.E419K		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	419	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTATATGGATGAGAGAAGGGA	0.348													7	13					0	0	0	0	A	141730195	A	A	141730195	3	1	211	1	0	0	0	0	1	0	0	0	9594	1291	45	2	1293	2	MGAM	7	141730195	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	5029810	141730195	17408468	83	38472											
PTPRN2	5799	broad.mit.edu	37	chr7	157959789	157959789	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggggcctctgggcagcataGgcactgagggccgccatcag	7	5	17	12	1	2	1	1	1	1	0	2	1	2	1	3	5	1	3	3	5	1	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr7:157959789G>A	uc003wno.2	-	6	865	c.744C>T	c.(742-744)GCC>GCT	p.A248A	PTPRN2_uc003wnp.2_Silent_p.A231A|PTPRN2_uc003wnq.2_Silent_p.A248A|PTPRN2_uc003wnr.2_Silent_p.A210A|PTPRN2_uc011kwa.1_Silent_p.A271A	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	248	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GGGCAGCATAGGCACTGAGGG	0.662													13	12					0	0	0	0	A	157959789	A	A	157959789	2	1	211	1	0	0	0	0	0	0	0	1	12873	987	35	4		4	PTPRN2	7	157959789	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	16229594	157959789	1178874	84	38473											
EFHA2	286097	broad.mit.edu	37	chr8	16884802	16884802	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccgctatggctgcgctgcGaaggctcttgtggccgccac	4	9	13	15	4	1	0	0	0	1	0	2	1	2	0	3	3	2	4	3	3	2	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr8:16884802G>T	uc003wxd.2	+	1	56	c.14G>T	c.(13-15)CGA>CTA	p.R5L		NM_181723	NP_859074	Q86XE3	EFHA2_HUMAN	EF-hand domain family, member A2	5						integral to membrane	calcium ion binding			skin(1)	1				Colorectal(111;0.0686)|COAD - Colon adenocarcinoma(73;0.239)		GCTGCGCTGCGAAGGCTCTTG	0.622													8	15					1.58986e-06	1.74754e-06	1	0	T	16884802	T	T	16884802	3	4	211	1	0	0	0	0	1	0	0	0	4966	1058	37	3	16	3	EFHA2	8	16884802	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08		16884802	129479220	85	38474											
DUSP26	78986	broad.mit.edu	37	chr8	33451188	33451188	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cataggcctcgggcgtgcctCgccaccggctgtgtgaggca	5	7	15	14	4	0	1	0	1	0	0	2	1	0	1	4	4	1	2	4	4	1	1	rs141858173		TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr8:33451188C>T	uc003xjp.2	-	3	632	c.299G>A	c.(298-300)CGA>CAA	p.R100Q	DUSP26_uc003xjq.2_Missense_Mutation_p.R100Q	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	100	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		GGGCGTGCCTCGCCACCGGCT	0.632													10	34					0	0	0	0	T	33451188	T	T	33451188	3	4	211	1	0	0	0	0	1	0	0	0	4845	884	31	1	344	1	DUSP26	8	33451188	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	16566386	33451188	112912834	86	38475											
PRDM14	63978	broad.mit.edu	37	chr8	70978695	70978695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacatccagttccccgtacCtccttttccatctataaagt	9	13	5	14	1	1	0	0	0	1	0	5	1	5	1	6	1	1	2	6	1	4	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr8:70978695C>T	uc003xym.2	-	5	1160	c.958G>A	c.(958-960)GGT>AGT	p.G320S		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	320	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TTCCCCGTACCTCCTTTTCCA	0.408													36	50					0	0	0	0	T	70978695	T	T	70978695	3	4	211	1	0	0	0	0	1	0	0	0	12517	681	24	4	773	4	PRDM14	8	70978695	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	37527507	70978695	75385327	87	38476											
TMEM67	91147	broad.mit.edu	37	chr8	94821068	94821068	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taaattctttaacttttcagGaaaatttgtgtagccagaga	14	15	7	5	0	2	1	1	0	1	1	2	3	2	2	1	1	2	1	1	1	6	8			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr8:94821068G>A	uc011lgk.1	+	24	2511	c.2440G>A	c.(2440-2442)GAA>AAA	p.E814K	TMEM67_uc010maw.2_Missense_Mutation_p.E520K|TMEM67_uc003yga.3_Missense_Mutation_p.E733K|TMEM67_uc011lgl.1_Missense_Mutation_p.E213K	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	814					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			AACTTTTCAGGAAAATTTGTG	0.308													4	18					0	0	0	0	A	94821068	A	A	94821068	3	1	211	1	0	0	0	0	1	0	0	0	16262	1188	41	2	2672	2	TMEM67	8	94821068	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	23842373	94821068	51542954	88	38477											
TSPYL5	85453	broad.mit.edu	37	chr8	98289495	98289495	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttccgtcgctgggggccccGaccctgcatccctctcttcc	2	10	9	20	3	1	0	0	0	1	0	6	1	4	0	6	2	1	2	6	2	0	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr8:98289495G>A	uc003yhy.2	-	1	682	c.578C>T	c.(577-579)TCG>TTG	p.S193L		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	193					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					TGGGGGCCCCGACCCTGCATC	0.622													24	96					0	0	0	0	A	98289495	A	A	98289495	3	1	211	1	0	0	0	0	1	0	0	0	16729	1059	37	1	679	1	TSPYL5	8	98289495	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	3468427	98289495	48074527	89	38478											
RRM2B	50484	broad.mit.edu	37	chr8	103236307	103236307	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctatctgctatccatcgcaAggcccaatctgcttttttct	7	16	5	13	1	4	0	0	0	4	0	6	0	5	0	2	1	2	3	2	1	4	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr8:103236307A>G	uc003ykn.2	-	5	761	c.517T>C	c.(517-519)TTG>CTG	p.L173L	RRM2B_uc003yko.2_RNA|RRM2B_uc010mbv.1_Silent_p.L121L|RRM2B_uc010mbw.1_Intron|RRM2B_uc010mbx.1_Intron|RRM2B_uc010mby.1_Intron	NM_015713	NP_056528	Q7LG56	RIR2B_HUMAN	ribonucleotide reductase M2 B (TP53 inducible)	173					deoxyribonucleoside diphosphate metabolic process|DNA repair|nucleobase, nucleoside and nucleotide interconversion	nucleoplasm	ribonucleoside-diphosphate reductase activity|transition metal ion binding			ovary(2)	2	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000728)			ATCCATCGCAAGGCCCAATCT	0.333								Direct_reversal_of_damage|Modulation_of_nucleotide_pools					66	82					0	0	0	0	G	103236307	G	G	103236307	2	3	211	1	0	0	0	0	0	0	0	1	13748	69	3	5		5	RRM2B	8	103236307	Silent	SNP	A	TCGA-CV-6956-01A-21D-2012-08	4946812	103236307	43127715	90	38479											
PKHD1L1	93035	broad.mit.edu	37	chr8	110461669	110461669	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaatgtgcaattgacaggcTtagatctgattacacaacac	15	10	8	8	0	1	4	0	2	1	2	1	4	1	4	0	1	3	2	0	1	5	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr8:110461669T>A	uc003yne.2	+	40	6232	c.6128T>A	c.(6127-6129)CTT>CAT	p.L2043H		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2043	Extracellular (Potential).|IPT/TIG 13.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTGACAGGCTTAGATCTGAT	0.353										HNSCC(38;0.096)			5	5					0	0	0	0	A	110461669	A	A	110461669	3	1	211	1	0	0	0	0	1	0	0	0	12027	1609	56	5	6286	5	PKHD1L1	8	110461669	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	7225362	110461669	35902353	91	38480											
COL14A1	7373	broad.mit.edu	37	chr8	121256222	121256222	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacacggatggcgaaggcgtCagcgtctccgctcctggaaa	9	7	13	12	5	2	0	1	0	1	0	4	3	3	2	2	4	2	1	2	4	3	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr8:121256222C>T	uc003yox.2	+	20	2719	c.2454C>T	c.(2452-2454)GTC>GTT	p.V818V	COL14A1_uc003yoy.2_Silent_p.V496V	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	818	Fibronectin type-III 6.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GCGAAGGCGTCAGCGTCTCCG	0.498													15	153					0	0	0	0	T	121256222	T	T	121256222	2	4	211	1	0	0	0	0	0	0	0	1	3686	813	29	2		2	COL14A1	8	121256222	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	10794553	121256222	25107800	92	38481											
DOCK8	81704	broad.mit.edu	37	chr9	289552	289552	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agggactgtgttcagacctaCatccgtgagtggctaatcgt	9	11	12	9	2	1	2	1	1	0	1	3	3	2	3	2	2	1	2	2	2	2	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr9:289552C>T	uc003zgf.2	+	4	487	c.375C>T	c.(373-375)TAC>TAT	p.Y125Y	DOCK8_uc011lls.1_Silent_p.Y125Y|DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Silent_p.Y57Y|DOCK8_uc010mgt.2_Silent_p.Y57Y|DOCK8_uc003zgg.2_Silent_p.Y57Y|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	125					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TTCAGACCTACATCCGTGAGT	0.328													9	47					0	0	0	0	T	289552	T	T	289552	2	4	211	1	0	0	0	0	0	0	0	1	4715	489	17	4		4	DOCK8	9	289552	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08		289552	140923879	93	38482											
SYK	6850	broad.mit.edu	37	chr9	93650843	93650843	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgttagagaaaggagagcGgatggggtgccctgcagggt	10	8	18	5	1	0	2	0	0	0	2	0	5	0	3	1	5	3	2	1	5	3	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr9:93650843G>A	uc004aqz.2	+	13	1974	c.1769G>A	c.(1768-1770)CGG>CAG	p.R590Q	SYK_uc004ara.2_Missense_Mutation_p.R567Q|SYK_uc004arb.2_Missense_Mutation_p.R567Q|SYK_uc004arc.2_Missense_Mutation_p.R590Q|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	590	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						AAAGGAGAGCGGATGGGGTGC	0.438			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								6	16					0	0	0	0	A	93650843	A	A	93650843	3	1	211	1	0	0	0	0	1	0	0	0	15504	1116	39	1	1815	1	SYK	9	93650843	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	93361291	93650843	47562588	94	38483											
NCBP1	4686	broad.mit.edu	37	chr9	100403139	100403139	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactgaagatcatttggaatCtttaatatgtaaagtaggag	16	13	9	3	0	2	2	1	1	1	1	2	4	2	4	0	2	1	2	0	2	8	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr9:100403139C>G	uc004axq.2	+	2	557	c.98C>G	c.(97-99)TCT>TGT	p.S33C		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	33	MIF4G.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				CATTTGGAATCTTTAATATGT	0.358													28	51					0	0	0	0	G	100403139	G	G	100403139	3	3	211	1	0	0	0	0	1	0	0	0	10265	913	32	2	104	2	NCBP1	9	100403139	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	6752296	100403139	40810292	95	38484											
OR1J2	26740	broad.mit.edu	37	chr9	125273891	125273891	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taagcagttctattgacaagGatgtcattgtggctctcatg	10	14	10	7	0	3	1	2	1	2	0	4	2	3	2	0	2	1	3	0	2	3	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr9:125273891G>A	uc004bmj.1	+	4	1666	c.811G>A	c.(811-813)GAT>AAT	p.D271N	OR1J2_uc011lyv.1_Missense_Mutation_p.D271N	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|pancreas(1)|breast(1)	5						TATTGACAAGGATGTCATTGT	0.473													62	126					0	0	0	0	A	125273891	A	A	125273891	3	1	211	1	0	0	0	0	1	0	0	0	11014	1174	41	2	813	2	OR1J2	9	125273891	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	24870752	125273891	15939540	96	38485											
DENND1A	57706	broad.mit.edu	37	chr9	126144077	126144077	+	Frame_Shift_Del	DEL	G	-	-																															aggttgggcatggagagggcGgagaggttgggctgagacct																										TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr9:126144077delG	uc004bnz.1	-	22	2897	c.2664delC	c.(2662-2664)TCCfs	p.S888fs	DENND1A_uc011lzl.1_Frame_Shift_Del_p.S706fs|DENND1A_uc004bny.1_Frame_Shift_Del_p.S670fs|DENND1A_uc011lzm.1_Frame_Shift_Del_p.S899fs|DENND1A_uc010mwh.1_Frame_Shift_Del_p.S309fs	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	888	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						TGGAGAGGGCGGAGAGGTTGG	0.682													---	---	---								-	126144077	-	-	126144077	7	5	211	1	0	1	0	1	0	0	0	0	4448	1103	39	0	369	0	DENND1A	9	126144077	Frame_Shift_Del	DEL	G	TCGA-CV-6956-01A-21D-2012-08	870186	126144077	15069354	97	38486											
TTC16	158248	broad.mit.edu	37	chr9	130482360	130482360	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccctgtgtccccagggaCaatgcctttttgagcagtgt	6	12	11	12	0	0	1	0	1	0	0	2	2	2	2	5	1	2	1	5	1	1	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr9:130482360C>T	uc004brq.1	+	5	497	c.430C>T	c.(430-432)CAA>TAA	p.Q144*	PTRH1_uc011mah.1_Intron|TTC16_uc011mai.1_Nonsense_Mutation_p.Q131*|TTC16_uc004brr.1_Nonsense_Mutation_p.Q89*|TTC16_uc010mxn.1_5'Flank	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	144	TPR 3.						binding				0						TCCCCAGGGACAATGCCTTTT	0.577													45	51					0	0	0	0	T	130482360	T	T	130482360	4	4	211	1	0	0	0	0	0	1	0	0	16751	479	17	4	448	4	TTC16	9	130482360	Nonsense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	4338283	130482360	10731071	98	38487											
SEC16A	9919	broad.mit.edu	37	chr9	139366454	139366454	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggccgttccgaggagtggCtggctcgggagctgggccgc	3	7	20	11	4	0	0	0	0	0	0	2	3	1	2	3	6	1	4	3	6	0	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr9:139366454C>T	uc004chx.2	-	4	3986	c.3677G>A	c.(3676-3678)AGC>AAC	p.S1226N	SEC16A_uc004chv.3_Missense_Mutation_p.S616N|SEC16A_uc004chw.2_Missense_Mutation_p.S1226N|SEC16A_uc010nbn.2_Missense_Mutation_p.S1226N	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1048	Required for endoplasmic reticulum localization.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CGAGGAGTGGCTGGCTCGGGA	0.637													33	37					0	0	0	0	T	139366454	T	T	139366454	3	4	211	1	0	0	0	0	1	0	0	0	14051	797	28	4	3512	4	SEC16A	9	139366454	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	8884094	139366454	1846977	99	38488											
ENTPD8	377841	broad.mit.edu	37	chr9	140330690	140330690	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgtggtctggtagccgctGaggtagcacgggtgacggag	7	8	19	7	3	1	2	0	2	1	0	1	3	1	3	1	5	2	4	1	5	2	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr9:140330690G>A	uc004cmw.2	-	7	1009	c.825C>T	c.(823-825)CTC>CTT	p.L275L	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Silent_p.L275L	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	275	Extracellular (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		GGTAGCCGCTGAGGTAGCACG	0.706													12	32					0	0	0	0	A	140330690	A	A	140330690	2	1	211	1	0	0	0	0	0	0	0	1	5169	1277	45	2		2	ENTPD8	9	140330690	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	964236	140330690	882741	100	38489											
ITGA8	8516	broad.mit.edu	37	chr10	15726024	15726024	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttccggcaaggagagaactCggcataggcgctgaagttct	10	8	14	9	3	1	2	0	1	1	1	3	4	2	3	1	4	1	5	1	4	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr10:15726024C>A	uc001ioc.1	-	4	547	c.547G>T	c.(547-549)GAG>TAG	p.E183*	ITGA8_uc010qcb.1_Nonsense_Mutation_p.E183*	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	183	Extracellular (Potential).|FG-GAP 2.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GGAGAGAACTCGGCATAGGCG	0.458													16	42					3.45872e-05	3.70975e-05	1	0	A	15726024	A	A	15726024	4	1	211	1	0	0	0	0	0	1	0	0	7921	893	31	3	2752	3	ITGA8	10	15726024	Nonsense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08		15726024	119808723	101	38490											
C10orf140	387640	broad.mit.edu	37	chr10	21804965	21804965	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtaggcatttcctagcctctCggagtattctttgttgtgga	6	16	11	8	1	2	0	0	0	2	0	4	2	3	2	2	3	1	4	2	3	3	7			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr10:21804965C>G	uc009xkd.2	-	4	4040	c.1787G>C	c.(1786-1788)CGA>CCA	p.R596P	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	515						nucleus	nucleotide binding			ovary(1)	1						CCTAGCCTCTCGGAGTATTCT	0.438													16	81					0	0	0	0	G	21804965	G	G	21804965	3	3	211	1	0	0	0	0	1	0	0	0	1601	884	31	3	943	3	C10orf140	10	21804965	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	6078941	21804965	113729782	102	38491											
ANKRD26	22852	broad.mit.edu	37	chr10	27366291	27366291	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ataagaccagggtttgctaaCgacttgtgggaaggttttgg	10	12	14	5	1	0	1	0	0	0	1	0	3	0	2	1	4	2	3	1	4	3	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr10:27366291C>T	uc001ith.2	-	9	1225	c.1053G>A	c.(1051-1053)TCG>TCA	p.S351S	ANKRD26_uc001itg.2_Silent_p.S70S|ANKRD26_uc009xku.1_Silent_p.S351S	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	351						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						GGTTTGCTAACGACTTGTGGG	0.383													38	58					0	0	0	0	T	27366291	T	T	27366291	2	4	211	1	0	0	0	0	0	0	0	1	654	523	19	1		1	ANKRD26	10	27366291	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	5561326	27366291	108168456	103	38492											
ARMC4	55130	broad.mit.edu	37	chr10	28196653	28196653	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggccttcacgtctgggtgaGgatttttcagcagggaccac	7	11	13	10	1	3	1	2	1	1	0	3	3	3	3	2	4	1	1	2	4	0	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr10:28196653G>A	uc009xky.2	-	17	2647	c.2549C>T	c.(2548-2550)CCT>CTT	p.P850L	ARMC4_uc010qds.1_Missense_Mutation_p.P375L|ARMC4_uc010qdt.1_Missense_Mutation_p.P542L|ARMC4_uc001itz.2_Missense_Mutation_p.P850L	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	850	ARM 6.						binding			ovary(4)|skin(2)	6						GTCTGGGTGAGGATTTTTCAG	0.443													18	40					0	0	0	0	A	28196653	A	A	28196653	3	1	211	1	0	0	0	0	1	0	0	0	955	1000	35	4	601	4	ARMC4	10	28196653	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	830362	28196653	107338094	104	38493											
CSGALNACT2	55454	broad.mit.edu	37	chr10	43650762	43650762	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggggaaaattatggtaaagaGtattatcaagccctcctaca	15	10	9	7	0	1	1	1	0	0	1	2	2	2	2	2	3	2	2	2	3	9	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr10:43650762G>A	uc001jan.2	+	2	500	c.165G>A	c.(163-165)GAG>GAA	p.E55E	CSGALNACT2_uc001jam.1_Silent_p.E55E	NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	55	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						ATGGTAAAGAGTATTATCAAG	0.418													15	44					0	0	0	0	A	43650762	A	A	43650762	2	1	211	1	0	0	0	0	0	0	0	1	3956	1020	36	4		4	CSGALNACT2	10	43650762	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	15454109	43650762	91883985	105	38494											
GPRIN2	9721	broad.mit.edu	37	chr10	46999149	46999149	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acccagtgctggaggccactGgtggagcagcactgtgggca	8	6	16	11	0	0	0	0	0	0	0	0	2	0	2	2	5	3	4	2	5	0	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr10:46999149G>C	uc001jec.2	+	3	404	c.269G>C	c.(268-270)TGG>TCG	p.W90S	GPRIN2_uc010qfq.1_5'Flank	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	90											0						GGAGGCCACTGGTGGAGCAGC	0.667													9	58					0	0	0	0	C	46999149	C	C	46999149	3	2	211	1	0	0	0	0	1	0	0	0	6769	1357	47	4	271	4	GPRIN2	10	46999149	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	3348387	46999149	88535598	106	38495											
SUPV3L1	6832	broad.mit.edu	37	chr10	70962246	70962246	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaaatgtttgcctaccatCtccctgatgcaacactgtcc	9	13	6	13	0	1	2	0	2	1	0	3	2	2	2	4	0	4	2	4	0	3	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr10:70962246C>G	uc001jpe.1	+	12	1625	c.1570C>G	c.(1570-1572)CTC>GTC	p.L524V	SUPV3L1_uc010qjd.1_Missense_Mutation_p.L393V	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	524					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						TGCCTACCATCTCCCTGATGC	0.373													23	53					0	0	0	0	G	70962246	G	G	70962246	3	3	211	1	0	0	0	0	1	0	0	0	15468	913	32	2	1616	2	SUPV3L1	10	70962246	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	23963097	70962246	64572501	107	38496											
HTR7	3363	broad.mit.edu	37	chr10	92509226	92509226	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcatcatttacattctgaGcccatccaaagagtggaggt	12	12	8	9	0	3	2	2	1	1	1	4	3	4	3	2	2	2	0	2	2	3	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr10:92509226G>C	uc001kha.2	-	2	908	c.665C>G	c.(664-666)GCT>GGT	p.A222G	HTR7_uc001kgz.2_Missense_Mutation_p.A222G|HTR7_uc001khb.2_Missense_Mutation_p.A222G	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	222	Helical; Name=4; (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	TACATTCTGAGCCCATCCAAA	0.483													40	58					0	0	0	0	C	92509226	C	C	92509226	3	2	211	1	0	0	0	0	1	0	0	0	7491	971	34	4	790	4	HTR7	10	92509226	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	21546980	92509226	43025521	108	38497											
CASP7	840	broad.mit.edu	37	chr10	115481445	115481445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acggaacagacaaagatgccGaggcgctcttcaagtgcttc	12	7	11	11	3	2	2	1	0	1	2	3	4	2	3	1	2	3	2	1	2	3	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr10:115481445G>A	uc001lan.2	+	4	457	c.283G>A	c.(283-285)GAG>AAG	p.E95K	CASP7_uc001lam.2_Missense_Mutation_p.E95K|CASP7_uc001lao.2_Missense_Mutation_p.E128K|CASP7_uc001lap.2_Missense_Mutation_p.E95K|CASP7_uc001laq.2_Missense_Mutation_p.E95K|CASP7_uc010qsa.1_Missense_Mutation_p.E180K|CASP7_uc010qsb.1_Missense_Mutation_p.E70K	NM_033339	NP_203125	P55210	CASP7_HUMAN	caspase 7 isoform alpha	95					activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis	cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm	cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0946)|Breast(234;0.188)		Epithelial(162;0.012)|all cancers(201;0.014)		CAAAGATGCCGAGGCGCTCTT	0.502													39	71					0	0	0	0	A	115481445	A	A	115481445	3	1	211	1	0	0	0	0	1	0	0	0	2688	1059	37	1	396	1	CASP7	10	115481445	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	22972219	115481445	20053302	109	38498											
MMP21	118856	broad.mit.edu	37	chr10	127462419	127462420	+	Missense_Mutation	DNP	GA	TT	TT																															cctctcccaaagcccagcttGatgtcgaccgcggccccggg																										TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr10:127462419_127462420GA>TT	uc001liu.2	-	2	677_678	c.677_678TC>AA	c.(676-678)ATC>AAA	p.I226K		NM_147191	NP_671724	Q8N119	MMP21_HUMAN	matrix metalloproteinase 21 preproprotein	226					proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AGCCCAGCTTGATGTCGACCGC	0.728													23	40					0	0	0	0	TT	127462420	TT	TT	127462419	3	4	211	1	0	0	0	0	1	0	0	0	9713	1280	45	2	1055	2	MMP21	10	127462419	Missense_Mutation	DNP	GA	TCGA-CV-6956-01A-21D-2012-08	11980974	127462419	8072328	110	38499											
SAA4	6291	broad.mit.edu	37	chr11	18257396	18257396	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttaccttggagagcctcCttgaaaaacgaacgccagct	11	10	8	12	2	1	2	0	1	1	1	2	4	2	2	4	1	5	1	4	1	4	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:18257396C>T	uc001mny.2	-	2	174	c.78G>A	c.(76-78)AAG>AAA	p.K26K		NM_006512	NP_006503	P35542	SAA4_HUMAN	serum amyloid A4, constitutive precursor	26					acute-phase response	high-density lipoprotein particle					0						GGAGAGCCTCCTTGAAAAACG	0.493													24	79					0	0	0	0	T	18257396	T	T	18257396	2	4	211	1	0	0	0	0	0	0	0	1	13865	680	24	4		4	SAA4	11	18257396	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08		18257396	116749120	111	38500											
NAV2	89797	broad.mit.edu	37	chr11	20083856	20083856	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttttcttttaatagttcAtggatcctcactctccttgg	6	21	5	9	0	4	0	2	0	2	0	6	1	5	1	2	2	0	1	2	2	2	8			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:20083856A>G	uc010rdm.1	+	22	5364	c.5003A>G	c.(5002-5004)CAT>CGT	p.H1668R	NAV2_uc001mpp.2_Missense_Mutation_p.H1548R|NAV2_uc001mpr.3_Missense_Mutation_p.H1612R|NAV2_uc001mpt.2_Missense_Mutation_p.H661R|NAV2_uc009yhx.2_Missense_Mutation_p.H676R|NAV2_uc009yhy.1_Missense_Mutation_p.H574R|NAV2_uc009yhz.2_Missense_Mutation_p.H257R|NAV2_uc001mpu.2_Missense_Mutation_p.H50R	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1668	Ser-rich.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						TTAATAGTTCATGGATCCTCA	0.423													11	50					0	0	0	0	G	20083856	G	G	20083856	3	3	211	1	0	0	0	0	1	0	0	0	10237	217	8	5	5022	5	NAV2	11	20083856	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08	1826460	20083856	114922660	112	38501											
TRIM48	79097	broad.mit.edu	37	chr11	55032387	55032387	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcctcagaaacatgaattCtggaatctcgcaagtcttcc	11	12	6	12	1	4	2	1	1	3	1	7	3	6	3	2	1	1	1	2	1	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:55032387C>T	uc010rid.1	+	2	142	c.56C>T	c.(55-57)TCT>TTT	p.S19F		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	3						intracellular	zinc ion binding				0						AACATGAATTCTGGAATCTCG	0.463													89	188					0	0	0	0	T	55032387	T	T	55032387	3	4	211	1	0	0	0	0	1	0	0	0	16590	913	32	2	62	2	TRIM48	11	55032387	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	34948531	55032387	79974129	113	38502											
OR5D16	390144	broad.mit.edu	37	chr11	55606573	55606573	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtagtgactgaattaattCtatttgcggtgatggcctat	9	17	10	5	1	1	3	0	3	1	0	1	3	1	3	1	2	1	1	1	2	5	7			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:55606573C>G	uc010rio.1	+	1	346	c.346C>G	c.(346-348)CTA>GTA	p.L116V		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TGAATTAATTCTATTTGCGGT	0.438													47	84					0	0	0	0	G	55606573	G	G	55606573	3	3	211	1	0	0	0	0	1	0	0	0	11210	912	32	2	348	2	OR5D16	11	55606573	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	574186	55606573	79399943	114	38503											
SYVN1	84447	broad.mit.edu	37	chr11	64897499	64897499	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggaggcaggggcataccCatccagggaggagggaaggg	10	3	21	7	0	0	0	0	0	0	0	1	4	1	4	2	9	1	2	2	9	2	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:64897499C>A	uc001odb.2	-	13	1477	c.1383G>T	c.(1381-1383)ATG>ATT	p.M461I	SYVN1_uc001odc.2_Missense_Mutation_p.M460I|SYVN1_uc009yqc.2_Missense_Mutation_p.M409I	NM_172230	NP_757385	Q86TM6	SYVN1_HUMAN	synoviolin 1 isoform b	461	Pro-rich.|Cytoplasmic (Potential).				ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(1)	1						GGGGCATACCCATCCAGGGAG	0.647													7	14					5.18039e-06	5.62442e-06	1	0	A	64897499	A	A	64897499	3	1	211	1	0	0	0	0	1	0	0	0	15553	594	21	4	486	4	SYVN1	11	64897499	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	9290926	64897499	70109017	115	38504											
SERPINH1	871	broad.mit.edu	37	chr11	75277799	75277799	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagctgggcagccgactgtaCggacccagctcagtgagctt	9	7	13	12	2	1	1	1	1	0	0	1	3	1	2	2	2	5	5	2	2	2	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:75277799C>T	uc001owr.2	+	2	634	c.405C>T	c.(403-405)TAC>TAT	p.Y135Y	SERPINH1_uc009yuf.2_Silent_p.Y135Y|SERPINH1_uc009yug.2_Silent_p.Y135Y|SERPINH1_uc001ows.2_Silent_p.Y135Y|SERPINH1_uc001owt.2_5'Flank	NM_001235	NP_001226	P50454	SERPH_HUMAN	serine (or cysteine) proteinase inhibitor, clade	135					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			ovary(2)	2	Ovarian(111;0.11)					GCCGACTGTACGGACCCAGCT	0.642													16	25					0	0	0	0	T	75277799	T	T	75277799	2	4	211	1	0	0	0	0	0	0	0	1	14182	547	19	1		1	SERPINH1	11	75277799	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	10380300	75277799	59728717	116	38505											
UBE4A	9354	broad.mit.edu	37	chr11	118267058	118267059	+	Missense_Mutation	DNP	CC	TT	TT																															agatccctttaaccgtagtcCcctcaccatggaccagatcc																										TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:118267058_118267059CC>TT	uc001psw.2	+	20	3233_3234	c.3104_3105CC>TT	c.(3103-3105)CCC>CTT	p.P1035L	UBE4A_uc001psv.2_Missense_Mutation_p.P1042L	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	1035	U-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		AACCGTAGTCCCCTCACCATGG	0.421													23	42					0	0	0	0	TT	118267059	TT	TT	118267058	3	4	211	1	0	0	0	0	1	0	0	0	16950	623	22	4	3199	4	UBE4A	11	118267058	Missense_Mutation	DNP	CC	TCGA-CV-6956-01A-21D-2012-08	42989259	118267058	16739458	117	38506											
SORL1	6653	broad.mit.edu	37	chr11	121444948	121444948	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgtctttctatcccattttAgctaccaccatctgtgacct	7	17	4	13	0	3	1	0	1	3	0	4	1	4	1	4	0	2	1	4	0	3	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:121444948A>T	uc001pxx.2	+	24	3418	c.3338_splice	c.e24-2	p.P1113_splice	SORL1_uc010rzp.1_5'Flank	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class						cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ATCCCATTTTAGCTACCACCA	0.418													52	107					0	0	0	0	T	121444948	T	T	121444948	5	4	211	1	0	0	0	0	0	0	1	0	14998	434	15	5	3430	5	SORL1	11	121444948	Splice_Site	SNP	A	TCGA-CV-6956-01A-21D-2012-08	3177890	121444948	13561568	118	38507											
HSPA8	3312	broad.mit.edu	37	chr11	122928593	122928593	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcaaactttctccagctctTtctgttgatgttcaaattct	8	18	5	10	0	5	1	1	1	4	0	6	1	5	1	1	0	3	4	1	0	2	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:122928593T>A	uc001pyo.2	-	9	1868	c.1790A>T	c.(1789-1791)AAA>ATA	p.K597I	HSPA8_uc009zbc.2_Missense_Mutation_p.K361I|HSPA8_uc001pyp.2_Intron|HSPA8_uc010rzu.1_Missense_Mutation_p.K520I	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	597					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CTCCAGCTCTTTCTGTTGATG	0.463													53	88					0	0	0	0	A	122928593	A	A	122928593	3	1	211	1	0	0	0	0	1	0	0	0	7455	1841	64	5	154	5	HSPA8	11	122928593	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	1483645	122928593	12077923	119	38508											
OR10S1	219873	broad.mit.edu	37	chr11	123847492	123847492	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctccttgttccgcaaagTgtaaatgaatgggttgagca	11	11	10	9	1	0	2	0	2	0	0	2	2	2	2	3	1	1	5	3	1	4	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:123847492T>A	uc001pzm.1	-	1	907	c.907A>T	c.(907-909)ACT>TCT	p.T303S		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	303	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTCCGCAAAGTGTAAATGAAT	0.537													43	83					0	0	0	0	A	123847492	A	A	123847492	3	1	211	1	0	0	0	0	1	0	0	0	10972	1696	59	5	92	5	OR10S1	11	123847492	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	918899	123847492	11159024	120	38509											
APLP2	334	broad.mit.edu	37	chr11	130005458	130005458	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgccctgtcttcatcagAtgagctccttcaggagcagc	7	10	9	15	0	4	2	3	1	1	1	5	3	5	3	3	1	4	2	3	1	0	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr11:130005458A>G	uc010sby.1	+	13	1842	c.1685A>G	c.(1684-1686)GAT>GGT	p.D562G	APLP2_uc001qfp.2_Missense_Mutation_p.D562G|APLP2_uc001qfq.2_Missense_Mutation_p.D506G|APLP2_uc010sbz.1_Missense_Mutation_p.D350G|APLP2_uc001qfr.2_Missense_Mutation_p.D328G|APLP2_uc001qfs.2_Missense_Mutation_p.D333G|APLP2_uc001qfv.2_Missense_Mutation_p.D453G	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	562	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TCTTCATCAGATGAGCTCCTT	0.587													45	83					0	0	0	0	G	130005458	G	G	130005458	3	3	211	1	0	0	0	0	1	0	0	0	779	347	12	5	1735	5	APLP2	11	130005458	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08	6157966	130005458	5001058	121	38510											
PLBD1	79887	broad.mit.edu	37	chr12	14706306	14706306	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatttttgacttgtactgtCttttcagcaggcatccagta	9	16	7	9	0	2	1	1	1	1	0	3	1	3	1	1	1	2	4	1	1	2	7			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:14706306C>G	uc001rcc.1	-	2	317	c.156G>C	c.(154-156)AAG>AAC	p.K52N		NM_024829	NP_079105	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	52					lipid catabolic process	extracellular region	hydrolase activity				0						CTTGTACTGTCTTTTCAGCAG	0.413													26	38					0	0	0	0	G	14706306	G	G	14706306	3	3	211	1	0	0	0	0	1	0	0	0	12080	912	32	2	1545	2	PLBD1	12	14706306	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08		14706306	119145589	122	38511											
SLCO1A2	6579	broad.mit.edu	37	chr12	21467564	21467564	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caatgccaatcattataggtCtatgcagtttggttccaaaa	13	13	7	8	0	2	0	1	0	1	0	3	0	3	0	2	2	2	3	2	2	7	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:21467564C>G	uc001rer.2	-	3	505	c.254G>C	c.(253-255)AGA>ACA	p.R85T	SLCO1A2_uc001res.2_Missense_Mutation_p.R85T|SLCO1A2_uc010siq.1_Intron|SLCO1A2_uc010sio.1_Intron|SLCO1A2_uc010sip.1_Intron|SLCO1A2_uc001ret.2_Missense_Mutation_p.R83T|SLCO1A2_uc001reu.2_Missense_Mutation_p.R65T	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	85	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						CATTATAGGTCTATGCAGTTT	0.328													19	41					0	0	0	0	G	21467564	G	G	21467564	3	3	211	1	0	0	0	0	1	0	0	0	14786	913	32	2	1806	2	SLCO1A2	12	21467564	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	6761258	21467564	112384331	123	38512											
ITPR2	3709	broad.mit.edu	37	chr12	26808679	26808679	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tttttctttatccccaaaagGaaagggctggtttacaactt	11	15	7	8	0	1	0	0	0	1	0	2	1	2	1	2	3	2	2	2	3	6	7			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:26808679G>A	uc001rhg.2	-	20	2968	c.2551C>T	c.(2551-2553)CCT>TCT	p.P851S		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	851	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCCCCAAAAGGAAAGGGCTGG	0.338													37	61					0	0	0	0	A	26808679	A	A	26808679	3	1	211	1	0	0	0	0	1	0	0	0	7960	1174	41	2	5706	2	ITPR2	12	26808679	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	5341115	26808679	107043216	124	38513											
FKBP11	51303	broad.mit.edu	37	chr12	49319149	49319149	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcctcagcccggcacacCgccgcactgagcagcagcag	9	2	11	19	3	1	1	1	1	0	0	1	1	1	1	5	1	5	5	5	1	0	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:49319149C>A	uc001rsp.2	-	1	182	c.63G>T	c.(61-63)GCG>GCT	p.A21A	FKBP11_uc010sma.1_5'Flank|FKBP11_uc001rsq.3_Silent_p.A21A|FKBP11_uc010smb.1_Silent_p.A21A	NM_016594	NP_057678	Q9NYL4	FKB11_HUMAN	FK506 binding protein 11 isoform 1 precursor	21					protein folding	integral to membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						CCCGGCACACCGCCGCACTGa	0.632													3	25					0.00909568	0.00948804	1	0	A	49319149	A	A	49319149	2	1	211	1	0	0	0	0	0	0	0	1	5935	639	23	3		3	FKBP11	12	49319149	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	22510470	49319149	84532746	125	38514											
KRT78	196374	broad.mit.edu	37	chr12	53241878	53241878	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgccacttcgtctccaggaCcttgttctgctgctccagga	6	12	9	14	1	2	0	0	0	2	0	5	2	3	2	4	2	3	3	4	2	0	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:53241878C>T	uc001sbc.1	-	2	476	c.412G>A	c.(412-414)GTC>ATC	p.V138I		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	138	Coil 1A.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						GTCTCCAGGACCTTGTTCTGC	0.597													11	32					0	0	0	0	T	53241878	T	T	53241878	3	4	211	1	0	0	0	0	1	0	0	0	8530	507	18	4	1182	4	KRT78	12	53241878	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	3922729	53241878	80610017	126	38515											
MYO1A	4640	broad.mit.edu	37	chr12	57431381	57431381	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcttgccaaaggccagctccCccgaggacatgctcagctcc	8	7	9	17	1	2	0	1	0	1	0	4	2	4	1	5	2	4	3	5	2	1	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:57431381C>G	uc001smw.3	-	19	2249	c.2006G>C	c.(2005-2007)GGG>GCG	p.G669A	MYO1A_uc010sqz.1_Missense_Mutation_p.G507A|MYO1A_uc009zpd.2_Missense_Mutation_p.G669A	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	669	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						GGCCAGCTCCCCCGAGGACAT	0.512													107	229					0	0	0	0	G	57431381	G	G	57431381	3	3	211	1	0	0	0	0	1	0	0	0	10121	623	22	4	1165	4	MYO1A	12	57431381	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	4189503	57431381	76420514	127	38516											
PIP4K2C	79837	broad.mit.edu	37	chr12	57984921	57984922	+	5'Flank	INS	-	C	C																															gccggggggcggggccagcgINStcgccccgccccgtcctgcc																								rs145477125	by1000genomes	TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	e0a52d9d-41f2-46d3-8c62-df1241806397	g.chr12:57984921_57984922insC	uc001sou.2	+						PIP4K2C_uc001sot.2_5'Flank|PIP4K2C_uc010srs.1_5'Flank|PIP4K2C_uc010srt.1_5'Flank	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type							cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					cggggccagcgtcgccccgccc	0.574													---	---	---								C	57984922	C	C	57984921	6	5	211	0	1	1	1	0	0	0	0	0	11993	1160	40	0		0	PIP4K2C	12	57984921	5'Flank	INS	-	TCGA-CV-6956-01A-21D-2012-08	553540	57984921	75866974	128	38517											
OS9	10956	broad.mit.edu	37	chr12	58088661	58088661	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctgcttaccaagggcctggGatccctgagttgttgagccc	6	10	12	13	0	0	2	0	2	0	0	1	3	1	3	5	2	3	3	5	2	2	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:58088661G>A	uc001spj.2	+	2	350	c.291G>A	c.(289-291)GGG>GGA	p.G97G	OS9_uc010srx.1_Silent_p.G97G|OS9_uc001spk.2_Silent_p.G97G|OS9_uc001spl.2_Silent_p.G97G|OS9_uc001spm.2_Silent_p.G97G|OS9_uc001spn.2_Silent_p.G97G|OS9_uc010sry.1_Silent_p.G97G|OS9_uc010srz.1_Intron	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	97					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			AAGGGCCTGGGATCCCTGAGT	0.522													20	41					0	0	0	0	A	58088661	A	A	58088661	2	1	211	1	0	0	0	0	0	0	0	1	11326	1161	41	2		2	OS9	12	58088661	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	103740	58088661	75763234	129	38518											
SRGAP1	57522	broad.mit.edu	37	chr12	64521813	64521813	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaccgtggcctcaacaatGacagtcctgagcggaggcgc	11	5	13	12	3	1	3	1	2	0	1	2	4	2	4	3	3	3	0	3	3	3	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:64521813G>A	uc010ssp.1	+	21	2769	c.2713G>A	c.(2713-2715)GAC>AAC	p.D905N	SRGAP1_uc001srv.2_Missense_Mutation_p.D842N	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	905					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CCTCAACAATGACAGTCCTGA	0.617													31	54					0	0	0	0	A	64521813	A	A	64521813	3	1	211	1	0	0	0	0	1	0	0	0	15211	1290	45	2	2795	2	SRGAP1	12	64521813	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	6433152	64521813	69330082	130	38519											
PTPRB	5787	broad.mit.edu	37	chr12	71002999	71002999	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcccccagggtgtcactgcTatagatgaggctaaagttac	10	9	12	10	0	1	2	1	1	0	1	1	2	1	2	2	3	2	3	2	3	5	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:71002999T>G	uc001swb.3	-	2	205	c.175A>C	c.(175-177)AGC>CGC	p.S59R	PTPRB_uc010sto.1_Missense_Mutation_p.S59R|PTPRB_uc010stp.1_Missense_Mutation_p.S59R|PTPRB_uc001swc.3_Missense_Mutation_p.S277R|PTPRB_uc001swa.3_Missense_Mutation_p.S277R|PTPRB_uc001swd.3_Missense_Mutation_p.S276R|PTPRB_uc009zrr.1_Missense_Mutation_p.S156R|PTPRB_uc001swe.2_Missense_Mutation_p.S277R	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	59	Fibronectin type-III 1.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTGTCACTGCTATAGATGAGG	0.498													3	67					0	0	0	0	G	71002999	G	G	71002999	3	3	211	1	0	0	0	0	1	0	0	0	12861	1522	53	5	5942	5	PTPRB	12	71002999	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	6481186	71002999	62848896	131	38520											
ANO4	121601	broad.mit.edu	37	chr12	101520815	101520815	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaacgaaaggagaggaagaaGaatggaaaagcacaccacaa	22	1	12	6	1	0	3	0	0	0	3	0	8	0	5	1	3	2	1	1	3	8	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:101520815G>C	uc010svm.1	+	27	3407	c.2835G>C	c.(2833-2835)AAG>AAC	p.K945N	ANO4_uc001thw.2_Missense_Mutation_p.K910N|ANO4_uc001thx.2_Missense_Mutation_p.K945N|ANO4_uc001thy.2_Missense_Mutation_p.K465N	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	945	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						AGAGGAAGAAGAATGGAAAAG	0.488										HNSCC(74;0.22)			6	16					0	0	0	0	C	101520815	C	C	101520815	3	2	211	1	0	0	0	0	1	0	0	0	699	933	33	2	2828	2	ANO4	12	101520815	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	30517816	101520815	32331080	132	38521											
SELPLG	6404	broad.mit.edu	37	chr12	109017613	109017613	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtctgtgcctccgtggcCgtcagtcgagttgtctgtgc	2	13	15	11	3	3	0	1	0	2	0	5	1	4	0	3	2	2	1	3	2	0	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:109017613C>T	uc001tni.2	-	2	631	c.471G>A	c.(469-471)ACG>ACA	p.T157T	SELPLG_uc001tnh.2_Silent_p.T147T|SELPLG_uc010sxe.1_Silent_p.T173T	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	157	Extracellular (Potential).|12 X 10 AA tandem repeats.				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0						CCTCCGTGGCCGTCAGTCGAG	0.637													53	78					0	0	0	0	T	109017613	T	T	109017613	2	4	211	1	0	0	0	0	0	0	0	1	14085	639	23	1		1	SELPLG	12	109017613	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	7496798	109017613	24834282	133	38522											
CUX2	23316	broad.mit.edu	37	chr12	111746236	111746236	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctcttgtctcctagggcatGgccaagcctgaagactcact	8	10	9	14	0	3	2	1	1	2	1	4	2	3	2	4	2	1	1	4	2	3	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:111746236G>A	uc001tsa.1	+	14	1317	c.1164G>A	c.(1162-1164)ATG>ATA	p.M388I		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	388						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CCTAGGGCATGGCCAAGCCTG	0.612													18	27					0	0	0	0	A	111746236	A	A	111746236	3	1	211	1	0	0	0	0	1	0	0	0	4082	1348	47	4	1218	4	CUX2	12	111746236	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	2728623	111746236	22105659	134	38523											
RNF10	9921	broad.mit.edu	37	chr12	121000765	121000765	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagactcgggaagaggctctGtcgggattggccggaagcag	9	7	17	8	3	1	2	0	0	1	2	3	5	1	5	1	5	1	2	1	5	3	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:121000765G>T	uc001typ.3	+	8	1629	c.1146G>T	c.(1144-1146)CTG>CTT	p.L382L	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Silent_p.L288L	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	382					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAGAGGCTCTGTCGGGATTGG	0.537													30	48					6.00712e-18	7.32979e-18	1	0	T	121000765	T	T	121000765	2	4	211	1	0	0	0	0	0	0	0	1	13487	1364	48	4		4	RNF10	12	121000765	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	9254529	121000765	12851130	135	38524											
HNF1A	6927	broad.mit.edu	37	chr12	121434487	121434487	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatgaccatcgggcctggTgagcctgcctccctgggtcc	4	9	13	15	1	1	2	1	2	0	0	4	2	3	2	6	3	2	0	6	3	0	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:121434487T>A	uc001tzg.2	+	6	1274	c.1251T>A	c.(1249-1251)GGT>GGA	p.G417G	HNF1A_uc001tze.1_Silent_p.G417G|HNF1A_uc001tzf.2_Silent_p.G417G|HNF1A_uc010szn.1_Silent_p.G417G	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	417					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCGGGCCTGGTGAGCCTGCCT	0.632									Hepatic_Adenoma_Familial_Clustering_of				19	32					0	0	0	0	A	121434487	A	A	121434487	2	1	211	1	0	0	0	0	0	0	0	1	7290	1683	59	5		5	HNF1A	12	121434487	Silent	SNP	T	TCGA-CV-6956-01A-21D-2012-08	433722	121434487	12417408	136	38525											
WDR66	144406	broad.mit.edu	37	chr12	122361573	122361573	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agctttccttacaattggagGatgcagaaacagatgagctt	13	11	10	7	0	0	3	0	1	0	2	1	5	1	5	1	2	5	3	1	2	3	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:122361573G>A	uc009zxk.2	+	3	566	c.424G>A	c.(424-426)GAT>AAT	p.D142N		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	142							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		ACAATTGGAGGATGCAGAAAC	0.363													23	61					0	0	0	0	A	122361573	A	A	122361573	3	1	211	1	0	0	0	0	1	0	0	0	17385	1174	41	2	430	2	WDR66	12	122361573	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	927086	122361573	11490322	137	38526											
POLE	5426	broad.mit.edu	37	chr12	133249289	133249289	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggcccccgacgtaggtcTcagagtccagcacgtgtccg	6	7	13	15	5	1	1	1	0	1	1	4	2	3	1	4	2	1	2	4	2	1	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr12:133249289T>C	uc001uks.1	-	15	1654	c.1610A>G	c.(1609-1611)GAG>GGG	p.E537G	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.E510G	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	537					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GACGTAGGTCTCAGAGTCCAG	0.577								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					31	64					0	0	0	0	C	133249289	C	C	133249289	3	2	211	1	0	0	0	0	1	0	0	0	12251	1551	54	5	5390	5	POLE	12	133249289	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	10887716	133249289	602606	138	38527											
RNF17	56163	broad.mit.edu	37	chr13	25448319	25448319	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagattgttgccattaaagaAtttaatcctttatctatctt	13	18	4	6	0	2	2	0	0	2	2	3	2	3	2	2	0	1	1	2	0	7	9			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr13:25448319A>T	uc001upr.2	+	33	4556	c.4515A>T	c.(4513-4515)GAA>GAT	p.E1505D	RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.E1501D|RNF17_uc001ups.2_Missense_Mutation_p.E1444D|RNF17_uc010aac.2_Missense_Mutation_p.E697D|RNF17_uc010aad.2_Missense_Mutation_p.E515D	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1505	Tudor 4.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CCATTAAAGAATTTAATCCTT	0.328													31	36					0	0	0	0	T	25448319	T	T	25448319	3	4	211	1	0	0	0	0	1	0	0	0	13526	98	4	5	4645	5	RNF17	13	25448319	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08		25448319	89721559	139	38528											
N4BP2L2	10443	broad.mit.edu	37	chr13	33111164	33111164	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaatttcaccataagacaTctgagaaataaataaatcat	19	12	3	7	0	4	2	3	1	1	2	4	3	4	2	1	0	0	0	1	0	7	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr13:33111164T>A	uc001uuk.3	-	2	179	c.1A>T	c.(1-3)ATG>TTG	p.M1L	N4BP2L2_uc010abe.1_Missense_Mutation_p.M1L|N4BP2L2_uc010tdz.1_Intron|N4BP2L2_uc001uul.1_Missense_Mutation_p.M1L|N4BP2L2_uc001uum.2_5'Flank	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	1											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		CCATAAGACATCTGAGAAATA	0.284													10	14					0	0	0	0	A	33111164	A	A	33111164	3	1	211	1	0	0	0	0	1	0	0	0	10165	1449	50	5	3631	5	N4BP2L2	13	33111164	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	7662845	33111164	82058714	140	38529											
NBEA	26960	broad.mit.edu	37	chr13	35619136	35619137	+	Missense_Mutation	DNP	GG	AA	AA																															agctacagcatcactgtcaaGgagttgaagcttttgttcag																										TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr13:35619136_35619137GG>AA	uc001uvb.2	+	4	785_786	c.579_580GG>AA	c.(577-582)AAGGAG>AAAAAG	p.E194K		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	194						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TCACTGTCAAGGAGTTGAAGCT	0.416													9	14					0	0	0	0	AA	35619137	AA	AA	35619136	3	1	211	1	0	0	0	0	1	0	0	0	10240	991	35	4	589	4	NBEA	13	35619136	Missense_Mutation	DNP	GG	TCGA-CV-6956-01A-21D-2012-08	2507972	35619136	79550742	141	38530											
PCDH8	5100	broad.mit.edu	37	chr13	53419596	53419596	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgagatcctttttcagagCgtccccgctgatgtcggaat	8	12	11	10	3	1	3	1	2	0	2	4	6	3	4	3	1	1	1	3	1	1	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr13:53419596C>T	uc001vhi.2	-	2	3006	c.2803G>A	c.(2803-2805)GCT>ACT	p.A935T	PCDH8_uc001vhj.2_Missense_Mutation_p.A838T	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	935	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TTTTTCAGAGCGTCCCCGCTG	0.522													7	74					0	0	0	0	T	53419596	T	T	53419596	3	4	211	1	0	0	0	0	1	0	0	0	11571	768	27	1	417	1	PCDH8	13	53419596	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	17800460	53419596	61750282	142	38531											
MYCBP2	23077	broad.mit.edu	37	chr13	77632376	77632376	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggctggtgctgccgagaGcgcttcggtgaaacatatca	10	9	13	9	3	1	2	1	1	0	1	2	3	1	2	1	3	4	3	1	3	3	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr13:77632376G>A	uc001vkf.2	-	79	13283	c.13192C>T	c.(13192-13194)CTC>TTC	p.L4398F	MYCBP2_uc010aev.2_Missense_Mutation_p.L3802F|MYCBP2_uc001vke.2_Missense_Mutation_p.L1015F	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4398	RING-type; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GCTGCCGAGAGCGCTTCGGTG	0.458													49	105					0	0	0	0	A	77632376	A	A	77632376	3	1	211	1	0	0	0	0	1	0	0	0	10071	971	34	4	754	4	MYCBP2	13	77632376	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	24212780	77632376	37537502	143	38532											
SLITRK5	26050	broad.mit.edu	37	chr13	88329860	88329860	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caccgcgggcccgcgctgccCaaggtgaagacgcccgcggg	6	2	16	17	7	0	2	0	1	0	1	0	2	0	2	4	3	1	1	4	3	2	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr13:88329860C>A	uc001vln.2	+	2	2436	c.2217C>A	c.(2215-2217)CCC>CCA	p.P739P	SLITRK5_uc010tic.1_Silent_p.P498P	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	739	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCGCGCTGCCCAAGGTGAAGA	0.667													37	101					1.90571e-15	2.27318e-15	1	0	A	88329860	A	A	88329860	2	1	211	1	0	0	0	0	0	0	0	1	14810	581	21	4		4	SLITRK5	13	88329860	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	10697484	88329860	26840018	144	38533											
GPC6	10082	broad.mit.edu	37	chr13	95055462	95055462	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctggcactgcagagactGtgcagataatcttgggtttt	8	13	12	8	0	1	2	0	0	1	2	2	3	2	2	1	2	2	4	1	2	1	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr13:95055462G>T	uc001vlt.2	+	9	2291	c.1659G>T	c.(1657-1659)CTG>CTT	p.L553L		NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	553						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				TGCAGAGACTGTGCAGATAAT	0.517													6	41					8.12818e-05	8.64839e-05	1	0	T	95055462	T	T	95055462	2	4	211	1	0	0	0	0	0	0	0	1	6640	1364	48	4		4	GPC6	13	95055462	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	6725602	95055462	20114416	145	38534											
DOCK9	23348	broad.mit.edu	37	chr13	99566619	99566619	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggtagctatctaaaccggaaCcagaaccttccaatttgctt	12	11	7	11	1	1	1	0	0	1	1	2	2	2	2	4	2	5	3	4	2	7	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr13:99566619C>T	uc001vnt.2	-	9	981	c.926G>A	c.(925-927)GGT>GAT	p.G309D	DOCK9_uc001vnw.2_Missense_Mutation_p.G308D|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.G309D|DOCK9_uc010tis.1_Missense_Mutation_p.G308D|DOCK9_uc010tit.1_Missense_Mutation_p.G309D|DOCK9_uc010afu.1_Missense_Mutation_p.G124D	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	309					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TAAACCGGAACCAGAACCTTC	0.393													5	13					0	0	0	0	T	99566619	T	T	99566619	3	4	211	1	0	0	0	0	1	0	0	0	4716	507	18	4	5536	4	DOCK9	13	99566619	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	4511157	99566619	15603259	146	38535											
MYO16	23026	broad.mit.edu	37	chr13	109475526	109475526	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgaaagccgaaattgccTgggaagaaaaaatgaaagag	18	6	12	5	1	0	4	0	2	0	2	0	6	0	5	2	1	3	1	2	1	7	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr13:109475526T>A	uc001vqt.1	+	9	1057	c.931T>A	c.(931-933)TGG>AGG	p.W311R	MYO16_uc010agk.1_Missense_Mutation_p.W333R|MYO16_uc001vqu.1_Missense_Mutation_p.W111R	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	311					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CGAAATTGCCTGGGAAGAAAA	0.393													48	141					0	0	0	0	A	109475526	A	A	109475526	3	1	211	1	0	0	0	0	1	0	0	0	10117	1580	55	5	961	5	MYO16	13	109475526	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	9908907	109475526	5694352	147	38536											
ARHGEF7	8874	broad.mit.edu	37	chr13	111919973	111919973	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaaccctgtacctcacgtaTtgtgccaatcacccttctgc	10	11	5	15	1	3	0	2	0	1	0	3	0	3	0	4	0	4	2	4	0	5	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr13:111919973T>C	uc001vrs.2	+	10	1342	c.1092T>C	c.(1090-1092)TAT>TAC	p.Y364Y	ARHGEF7_uc001vrr.2_Silent_p.Y343Y|ARHGEF7_uc001vrt.2_Silent_p.Y314Y|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_Silent_p.Y186Y|ARHGEF7_uc001vrv.3_Silent_p.Y186Y|ARHGEF7_uc001vrw.3_Silent_p.Y186Y|ARHGEF7_uc001vrx.3_Silent_p.Y186Y|ARHGEF7_uc010tjo.1_Silent_p.Y261Y|ARHGEF7_uc010tjp.1_Silent_p.Y108Y|ARHGEF7_uc010agn.1_Silent_p.Y108Y	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	364	DH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			ACCTCACGTATTGTGCCAATC	0.532													30	60					0	0	0	0	C	111919973	C	C	111919973	2	2	211	1	0	0	0	0	0	0	0	1	911	1500	52	5		5	ARHGEF7	13	111919973	Silent	SNP	T	TCGA-CV-6956-01A-21D-2012-08	2444447	111919973	3249905	148	38537											
OR11H4	390442	broad.mit.edu	37	chr14	20711094	20711094	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtgatttatgtcttgacCttgctgggaaatggagccat	8	15	12	6	0	1	2	0	2	1	0	1	4	1	4	2	3	2	1	2	3	2	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr14:20711094C>T	uc010tld.1	+	1	144	c.144C>T	c.(142-144)ACC>ACT	p.T48T		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	48	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		ATGTCTTGACCTTGCTGGGAA	0.443													30	60					0	0	0	0	T	20711094	T	T	20711094	2	4	211	1	0	0	0	0	0	0	0	1	10982	668	24	4		4	OR11H4	14	20711094	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08		20711094	86638446	149	38538											
TOX4	9878	broad.mit.edu	37	chr14	21955828	21955828	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgatggagcagggcgggggGctcctgagtgggggcttgac	5	8	21	7	1	0	3	0	3	0	0	1	4	1	4	1	7	1	3	1	7	0	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr14:21955828G>A	uc001waz.2	+	3	397	c.294G>A	c.(292-294)GGG>GGA	p.G98G	TOX4_uc001way.2_5'UTR|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Silent_p.G75G|TOX4_uc010tlv.1_Intron	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	98						chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		AGGGCGGGGGGCTCCTGAGTG	0.557													35	55					0	0	0	0	A	21955828	A	A	21955828	2	1	211	1	0	0	0	0	0	0	0	1	16447	1190	42	4		4	TOX4	14	21955828	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	1244734	21955828	85393712	150	38539											
CTAGE5	4253	broad.mit.edu	37	chr14	39764138	39764138	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcacttaggccaaaatgAccttcaagatatttcaaatg	14	13	6	8	0	3	2	3	1	0	1	3	2	3	2	2	1	0	1	2	1	6	5	rs150627486	byFrequency	TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr14:39764138A>G	uc001wvg.3	+	8	913	c.577A>G	c.(577-579)ACC>GCC	p.T193A	CTAGE5_uc010tqe.1_Missense_Mutation_p.T155A|CTAGE5_uc001wuz.3_Missense_Mutation_p.T181A|CTAGE5_uc001wuy.3_Missense_Mutation_p.T113A|CTAGE5_uc001wvb.3_Missense_Mutation_p.T164A|CTAGE5_uc001wvc.3_Missense_Mutation_p.T138A|CTAGE5_uc001wva.3_Missense_Mutation_p.T164A|CTAGE5_uc001wve.1_Missense_Mutation_p.T169A|CTAGE5_uc001wvh.3_Missense_Mutation_p.T193A|CTAGE5_uc001wvf.3_Missense_Mutation_p.T118A|CTAGE5_uc001wvi.3_Missense_Mutation_p.T198A|CTAGE5_uc010amz.2_5'UTR|CTAGE5_uc001wvj.3_Missense_Mutation_p.T164A	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	193	Potential.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		GGCCAAAATGACCTTCAAGAT	0.313													4	88					0	0	0	0	G	39764138	G	G	39764138	3	3	211	1	0	0	0	0	1	0	0	0	4011	275	10	5	638	5	CTAGE5	14	39764138	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08	17808310	39764138	67585402	151	38540											
NIN	51199	broad.mit.edu	37	chr14	51259494	51259494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccagtggctcaatcaccGtcacttcaggaaactcctcc	10	9	6	16	1	4	0	4	0	0	0	7	1	7	1	4	2	1	1	4	2	2	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr14:51259494G>A	uc001wym.2	-	5	562	c.371C>T	c.(370-372)ACG>ATG	p.T124M	NIN_uc001wyi.2_Missense_Mutation_p.T124M|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.T124M|NIN_uc010tqp.1_Missense_Mutation_p.T130M|NIN_uc001wyo.2_Missense_Mutation_p.T124M|NIN_uc001wyp.1_Missense_Mutation_p.T86M	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	124					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					CTCAATCACCGTCACTTCAGG	0.542			T	PDGFRB	MPD								26	45					0	0	0	0	A	51259494	A	A	51259494	3	1	211	1	0	0	0	0	1	0	0	0	10471	1145	40	1	6286	1	NIN	14	51259494	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	11495356	51259494	56090046	152	38541											
PRKCH	5583	broad.mit.edu	37	chr14	61917604	61917604	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacatcccacacaagttcagCatccacaactacaaagtgcc	16	6	4	15	0	1	0	1	0	0	0	3	0	3	0	3	0	5	2	3	0	5	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr14:61917604C>T	uc001xfn.2	+	6	1052	c.747C>T	c.(745-747)AGC>AGT	p.S249S	PRKCH_uc010tsa.1_Silent_p.S88S	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	249	Phorbol-ester/DAG-type 2.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		ACAAGTTCAGCATCCACAACT	0.438													23	38					0	0	0	0	T	61917604	T	T	61917604	2	4	211	1	0	0	0	0	0	0	0	1	12575	709	25	4		4	PRKCH	14	61917604	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	10658110	61917604	45431936	153	38542											
ALKBH1	8846	broad.mit.edu	37	chr14	78161201	78161201	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcactgtttcacccagtgcCactggtaacctgggaggaag	9	8	13	11	0	1	0	1	0	0	0	1	2	1	2	3	4	2	3	3	4	2	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr14:78161201C>T	uc001xuc.1	-	3	344	c.335G>A	c.(334-336)TGG>TAG	p.W112*	ALKBH1_uc001xud.1_Intron	NM_006020	NP_006011	Q13686	ALKB1_HUMAN	alkylated DNA repair protein alkB homolog	112					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)|skin(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		CACCCAGTGCCACTGGTAACC	0.418													27	51					0	0	0	0	T	78161201	T	T	78161201	4	4	211	1	0	0	0	0	0	1	0	0	526	595	21	4	850	4	ALKBH1	14	78161201	Nonsense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	16243597	78161201	29188339	154	38543											
RCOR1	23186	broad.mit.edu	37	chr14	103148296	103148296	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttggtctggtcacccaatcaAaatctgtcagaagcaaagtg	13	10	9	9	0	5	1	3	0	2	1	5	1	5	1	1	2	1	1	1	2	5	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr14:103148296A>G	uc001ymb.2	+	3	417	c.417A>G	c.(415-417)CAA>CAG	p.Q139Q		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	139	Interaction with HDAC1.|ELM2.				blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						CACCCAATCAAAATCTGTCAG	0.373													13	18					0	0	0	0	G	103148296	G	G	103148296	2	3	211	1	0	0	0	0	0	0	0	1	13247	11	1	5		5	RCOR1	14	103148296	Silent	SNP	A	TCGA-CV-6956-01A-21D-2012-08	24987095	103148296	4201244	155	38544											
NIPA2	81614	broad.mit.edu	37	chr15	23006728	23006729	+	Frame_Shift_Ins	INS	-	G	G																															ggcccttcacacaggagactINSgaaaacgcgccgattacaga																										TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr15:23006728_23006729insG	uc001yux.2	-	8	1188_1189	c.575_576insC	c.(574-576)TCAfs	p.S192fs	NIPA2_uc001yuy.2_Frame_Shift_Ins_p.S192fs|NIPA2_uc001yuz.2_Frame_Shift_Ins_p.S192fs|NIPA2_uc001yva.2_Frame_Shift_Ins_p.S173fs|NIPA2_uc001yvb.2_Frame_Shift_Ins_p.S192fs|NIPA2_uc010ayb.2_Frame_Shift_Ins_p.S173fs	NM_030922	NP_112184	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome	192	Helical; (Potential).					early endosome|integral to membrane|plasma membrane				haematopoietic_and_lymphoid_tissue(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		CACAGGAGACTGAAAACGCGCC	0.52													---	---	---								G	23006729	G	G	23006728	7	5	211	1	0	1	1	0	0	0	0	0	10477	1567	55	0	510	0	NIPA2	15	23006728	Frame_Shift_Ins	INS	-	TCGA-CV-6956-01A-21D-2012-08		23006728	79524664	156	38545											
MAGEL2	54551	broad.mit.edu	37	chr15	23890016	23890016	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caggatgcgctgggcccttcCcagccactcaggatcctgga	7	7	12	15	1	1	0	1	0	0	0	3	3	3	3	4	4	2	1	4	4	0	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr15:23890016C>T	uc001ywj.3	-	1	1160	c.1065G>A	c.(1063-1065)TGG>TGA	p.W355*		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TGGGCCCTTCCCAGCCACTCA	0.672													19	29					0	0	0	0	T	23890016	T	T	23890016	4	4	211	1	0	0	0	0	0	1	0	0	9242	624	22	4	879	4	MAGEL2	15	23890016	Nonsense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	883288	23890016	78641376	157	38546											
C15orf55	256646	broad.mit.edu	37	chr15	34640628	34640628	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggagggtcctccaggccttCcgcctcagcctccaccacca	7	6	9	19	1	1	0	1	0	0	0	5	1	5	1	9	3	1	0	9	3	0	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr15:34640628C>T	uc001zif.2	+	2	630	c.475C>T	c.(475-477)CCG>TCG	p.P159S	C15orf55_uc010ucc.1_Missense_Mutation_p.P187S|C15orf55_uc010ucd.1_Missense_Mutation_p.P177S	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	159	Pro-rich.					cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		TCCAGGCCTTCCGCCTCAGCC	0.587			T	BRD3|BRD4	lethal midline carcinoma								11	28					0	0	0	0	T	34640628	T	T	34640628	3	4	211	1	0	0	0	0	1	0	0	0	1809	855	30	2	481	2	C15orf55	15	34640628	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	10750612	34640628	67890764	158	38547											
TMEM87A	25963	broad.mit.edu	37	chr15	42560198	42560198	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcttttcagataccaggttaTattcaaagacaggtcacaag	14	11	8	8	0	3	2	3	0	0	2	3	2	3	2	1	2	1	2	1	2	5	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr15:42560198T>C	uc010udd.1	-	3	397	c.238A>G	c.(238-240)ATA>GTA	p.I80V	TMEM87A_uc001zpf.3_Missense_Mutation_p.I19V|TMEM87A_uc010bcu.1_Missense_Mutation_p.I19V|TMEM87A_uc001zpg.2_Missense_Mutation_p.I80V	NM_015497	NP_056312	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A isoform 1	80						integral to membrane				ovary(1)	1		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		TACCAGGTTATATTCAAAGAC	0.259													25	46					0	0	0	0	C	42560198	C	C	42560198	3	2	211	1	0	0	0	0	1	0	0	0	16276	1406	49	5	1547	5	TMEM87A	15	42560198	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	7919570	42560198	59971194	159	38548											
TRPM7	54822	broad.mit.edu	37	chr15	50906377	50906378	+	Missense_Mutation	DNP	GC	AT	AT																															aaacgtttcctagtataggtGcatctgtaggttcctcccat																										TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr15:50906377_50906378GC>AT	uc001zyt.3	-	14	1841_1842	c.1577_1578GC>AT	c.(1576-1578)TGC>TAT	p.C526Y	TRPM7_uc010bew.1_Missense_Mutation_p.C526Y|TRPM7_uc001zyu.2_Missense_Mutation_p.C84Y	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	526	Cytoplasmic (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TAGTATAGGTGCATCTGTAGGT	0.327													18	38					0	0	0	0	AT	50906378	AT	AT	50906377	3	1	211	1	0	0	0	0	1	0	0	0	16658	1311	46	4	4123	4	TRPM7	15	50906377	Missense_Mutation	DNP	GC	TCGA-CV-6956-01A-21D-2012-08	8346179	50906377	51625015	160	38549											
NARG2	79664	broad.mit.edu	37	chr15	60741642	60741642	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtaaggcatcagatgttttCaagtcactatcttgtatcaa	12	15	7	7	0	5	1	4	0	1	1	5	1	5	1	0	1	0	4	0	1	5	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr15:60741642C>G	uc002agp.2	-	10	1759	c.1524G>C	c.(1522-1524)TTG>TTC	p.L508F	NARG2_uc002ago.2_Missense_Mutation_p.L371F|NARG2_uc002agq.3_Missense_Mutation_p.L176F	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	508						nucleus				ovary(1)|lung(1)	2						CAGATGTTTTCAAGTCACTAT	0.333													28	51					0	0	0	0	G	60741642	G	G	60741642	3	3	211	1	0	0	0	0	1	0	0	0	10222	825	29	2	1452	2	NARG2	15	60741642	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	9835265	60741642	41789750	161	38550											
C15orf39	56905	broad.mit.edu	37	chr15	75498857	75498857	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtgaagaggccactggaTgttgactggactctggcgac	9	8	15	9	1	1	3	0	2	1	1	1	6	1	5	1	4	0	2	1	4	1	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr15:75498857T>C	uc002azp.3	+	2	788	c.468T>C	c.(466-468)GAT>GAC	p.D156D	C15orf39_uc002azq.3_Silent_p.D156D|C15orf39_uc002azr.3_5'Flank	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	156											0						GGCCACTGGATGTTGACTGGA	0.622													37	66					0	0	0	0	C	75498857	C	C	75498857	2	2	211	1	0	0	0	0	0	0	0	1	1799	1461	51	5		5	C15orf39	15	75498857	Silent	SNP	T	TCGA-CV-6956-01A-21D-2012-08	14757215	75498857	27032535	162	38551											
CSPG4	1464	broad.mit.edu	37	chr15	75983101	75983101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatggagtcactcagcagcGtctctgctggagtctgcagc	7	9	14	11	1	4	0	2	0	2	0	5	3	4	3	0	3	5	3	0	3	0	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr15:75983101G>A	uc002baw.2	-	3	398	c.305C>T	c.(304-306)ACG>ATG	p.T102M		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	102	Extracellular (Potential).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 1.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						ACTCAGCAGCGTCTCTGCTGG	0.582													29	66					0	0	0	0	A	75983101	A	A	75983101	3	1	211	1	0	0	0	0	1	0	0	0	3977	1145	40	1	6695	1	CSPG4	15	75983101	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	484244	75983101	26548291	163	38552											
MFGE8	4240	broad.mit.edu	37	chr15	89453067	89453074	+	Frame_Shift_Del	DEL	GTGTACGA	-	-																															agcccttaaggcacgtgcagGtgtacgaggggaagacatct																								rs141997845		TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	e0a52d9d-41f2-46d3-8c62-df1241806397	g.chr15:89453067_89453074delGTGTACGA	uc002bng.3	-	2	267_274	c.154_161delTCGTACAC	c.(154-162)TCGTACACCfs	p.S52fs	MFGE8_uc002bnf.3_5'UTR|MFGE8_uc002bnh.3_Frame_Shift_Del_p.S52fs|MFGE8_uc010bnn.2_Frame_Shift_Del_p.S44fs|MFGE8_uc010upq.1_Intron|MFGE8_uc010upr.1_Frame_Shift_Del_p.S52fs|MFGE8_uc010bno.2_Intron	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	52_54	EGF-like.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					GCACGTGCAGGTGTACGAGGGGAAGACA	0.543													---	---	---								-	89453074	-	-	89453067	7	5	211	1	0	1	0	1	0	0	0	0	9573	1261	44	0	1030	0	MFGE8	15	89453067	Frame_Shift_Del	DEL	GTGTACGA	TCGA-CV-6956-01A-21D-2012-08	13469966	89453067	13078325	164	38553											
XYLT1	64131	broad.mit.edu	37	chr16	17292261	17292261	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagcacttgccgatgcaggTaattagagcgcttttcccag	9	10	12	10	2	0	1	0	0	0	1	1	3	1	2	2	2	4	4	2	2	2	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr16:17292261T>A	uc002dfa.2	-	5	1182	c.1097A>T	c.(1096-1098)TAC>TTC	p.Y366F		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	366	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CCGATGCAGGTAATTAGAGCG	0.587													10	17					0	0	0	0	A	17292261	A	A	17292261	3	1	211	1	0	0	0	0	1	0	0	0	17531	1638	57	5	1814	5	XYLT1	16	17292261	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08		17292261	73062492	165	38554											
ACSM3	6296	broad.mit.edu	37	chr16	20797459	20797459	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctggctcaatgggaaaaccTtctcctgctttcgatgttaa	9	13	8	11	1	2	0	1	0	1	0	4	2	2	1	3	2	2	3	3	2	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr16:20797459T>G	uc002dhr.2	+	9	1390	c.1203T>G	c.(1201-1203)CCT>CCG	p.P401P	ACSM3_uc002dhq.2_Silent_p.P401P|ACSM3_uc010vba.1_Silent_p.P430P|ERI2_uc002dhs.2_Intron	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	401					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						TGGGAAAACCTTCTCCTGCTT	0.388													15	23					0	0	0	0	G	20797459	G	G	20797459	2	3	211	1	0	0	0	0	0	0	0	1	185	1596	56	5		5	ACSM3	16	20797459	Silent	SNP	T	TCGA-CV-6956-01A-21D-2012-08	3505198	20797459	69557294	166	38555											
EARS2	124454	broad.mit.edu	37	chr16	23563530	23563530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcacaacgcgagtctgatCtgtgtcctctagcctcagga	9	9	11	12	2	4	1	1	1	3	0	5	3	5	2	2	2	2	1	2	2	2	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr16:23563530C>G	uc002dlt.3	-	2	267	c.235G>C	c.(235-237)GAT>CAT	p.D79H	EARS2_uc002dlr.3_5'Flank|EARS2_uc002dls.3_RNA|EARS2_uc002dlu.2_Missense_Mutation_p.D79H	NM_001083614	NP_001077083	Q5JPH6	SYEM_HUMAN	glutamyl-tRNA synthetase 2 precursor	79					glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding				0				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)	CGAGTCTGATCTGTGTCCTCT	0.547													35	71					0	0	0	0	G	23563530	G	G	23563530	3	3	211	1	0	0	0	0	1	0	0	0	4900	913	32	2	1368	2	EARS2	16	23563530	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	2766071	23563530	66791223	167	38556											
MAZ	4150	broad.mit.edu	37	chr16	29820025	29820025	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaccacatgaaggtgcacagCcagggtcctcaccatgtctg	10	7	11	13	0	2	1	1	1	1	0	3	2	3	1	4	2	2	1	4	2	1	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr16:29820025C>G	uc002dty.2	+	4	1410	c.1242C>G	c.(1240-1242)AGC>AGG	p.S414R	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAZ_uc002dtv.1_Intron|MAZ_uc010vdx.1_Missense_Mutation_p.S391R|MAZ_uc002dtw.2_Intron|MAZ_uc002dtx.2_Missense_Mutation_p.S414R|MAZ_uc010bzg.2_Missense_Mutation_p.S109R|MAZ_uc002dtz.1_3'UTR|MAZ_uc002dua.2_Missense_Mutation_p.S15R|MAZ_uc010vdy.1_Missense_Mutation_p.S15R|uc002duc.1_RNA	NM_002383	NP_002374	P56270	MAZ_HUMAN	MYC-associated zinc finger protein isoform 1	414					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1						AGGTGCACAGCCAGGGTCCTC	0.612													12	18					0	0	0	0	G	29820025	G	G	29820025	3	3	211	1	0	0	0	0	1	0	0	0	9393	738	26	4	1256	4	MAZ	16	29820025	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	6256495	29820025	60534728	168	38557											
FBXL19	54620	broad.mit.edu	37	chr16	30958233	30958233	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcctcacggcccccacgtccCcactccgcgagaccctggtg	5	6	9	21	4	1	1	1	0	0	1	4	2	4	1	7	2	0	0	7	2	0	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr16:30958233C>G	uc002eab.2	+	10	2028	c.1870C>G	c.(1870-1872)CCA>GCA	p.P624A	FBXL19_uc002dzz.1_Missense_Mutation_p.P312A|FBXL19_uc002eaa.1_Missense_Mutation_p.P523A|ORAI3_uc002eac.2_5'Flank	NM_001099784	NP_001093254	Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	624	LRR 4.						DNA binding|zinc ion binding			ovary(2)|lung(1)|breast(1)	4						CCCCACGTCCCCACTCCGCGA	0.682													5	14					0	0	0	0	G	30958233	G	G	30958233	3	3	211	1	0	0	0	0	1	0	0	0	5747	623	22	4	1908	4	FBXL19	16	30958233	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	1138208	30958233	59396520	169	38558											
ACAP1	9744	broad.mit.edu	37	chr17	7251469	7251469	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtgtgagctgggaaatgtCatcatcaaccagatctatga	13	11	10	7	0	4	3	3	2	1	1	4	4	4	4	1	1	2	1	1	1	3	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:7251469C>G	uc002ggd.2	+	16	1643	c.1437C>G	c.(1435-1437)GTC>GTG	p.V479V		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	479	Arf-GAP.|Required for interaction with GULP1.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						TGGGAAATGTCATCATCAACC	0.617													7	24					0	0	0	0	G	7251469	G	G	7251469	2	3	211	1	0	0	0	0	0	0	0	1	118	813	29	2		2	ACAP1	17	7251469	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08		7251469	73943741	170	38559											
TP53	7157	broad.mit.edu	37	chr17	7579356	7579359	+	Frame_Shift_Del	DEL	GACG	-	-																															cccagaatgcaagaagcccaGacggaaaccgtagctgccct																								rs11540654		TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:7579356_7579359delGACG	uc002gim.2	-	4	522_525	c.328_331delCGTC	c.(328-333)CGTCTGfs	p.R110fs	TP53_uc002gig.1_Frame_Shift_Del_p.R110fs|TP53_uc002gih.2_Frame_Shift_Del_p.R110fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.R110fs|TP53_uc010cni.1_Frame_Shift_Del_p.R110fs|TP53_uc002gij.2_Frame_Shift_Del_p.R110fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.R71fs|TP53_uc010cnk.1_Frame_Shift_Del_p.R125fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	110_111	|Interaction with HIPK1 (By similarity).		L -> Q (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> M (in a sporadic cancer; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R110L(24)|p.R110P(8)|p.0?(7)|p.R110fs*13(5)|p.R110C(4)|p.G59fs*23(3)|p.R110H(2)|p.F109_R110delFR(2)|p.Y107fs*38(1)|p.R110fs*18(1)|p.R110fs*39(1)|p.L111fs*10(1)|p.V73fs*9(1)|p.Y107fs*44(1)|p.L111M(1)|p.S33fs*23(1)|p.R110S(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.Y103_L111>L(1)|p.F109_R110insXX(1)|p.G105_T125del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAGAAGCCCAGACGGAAACCGTAG	0.613		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7579359	-	-	7579356	7	5	211	1	0	1	0	1	0	0	0	0	16448	933	33	0	971	0	TP53	17	7579356	Frame_Shift_Del	DEL	GACG	TCGA-CV-6956-01A-21D-2012-08	327887	7579356	73615854	171	38560											
CNTROB	116840	broad.mit.edu	37	chr17	7839728	7839728	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagacccgagtgttagaGctacagcaacaattagccgt	12	8	10	11	2	0	2	0	0	0	2	0	3	0	2	2	0	6	4	2	0	5	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:7839728G>C	uc002gjq.2	+	6	1558	c.639G>C	c.(637-639)GAG>GAC	p.E213D	CNTROB_uc002gjp.2_Missense_Mutation_p.E213D|CNTROB_uc002gjr.2_Missense_Mutation_p.E115D|CNTROB_uc010vum.1_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	213	Potential.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				GAGTGTTAGAGCTACAGCAAC	0.527													38	98					0	0	0	0	C	7839728	C	C	7839728	3	2	211	1	0	0	0	0	1	0	0	0	3666	962	34	4	657	4	CNTROB	17	7839728	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	260372	7839728	73355482	172	38561											
RASD1	51655	broad.mit.edu	37	chr17	17399294	17399294	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagctggtagacctcgccgcGgatggagtagaacttgcggt	8	8	16	9	4	0	2	0	0	0	2	1	5	0	4	2	4	3	3	2	4	3	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:17399294G>T	uc002gri.2	-	1	414	c.202C>A	c.(202-204)CGC>AGC	p.R68S		NM_016084	NP_057168	Q9Y272	RASD1_HUMAN	RAS, dexamethasone-induced 1 precursor	68					G-protein coupled receptor protein signaling pathway|small GTPase mediated signal transduction	nucleus|perinuclear region of cytoplasm|plasma membrane	GTP binding|GTPase activity				0						ACCTCGCCGCGGATGGAGTAG	0.672													15	72					3.41278e-10	3.89614e-10	1	0	T	17399294	T	T	17399294	3	4	211	1	0	0	0	0	1	0	0	0	13131	1116	39	3	651	3	RASD1	17	17399294	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	9559566	17399294	63795916	173	38562											
PRPSAP2	5636	broad.mit.edu	37	chr17	18833957	18833957	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcagaggcgatccgtcggatCcacaatggggagtccatgtc	9	8	13	11	3	1	1	1	0	0	1	6	4	4	3	3	4	0	0	3	4	1	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:18833957C>T	uc002gup.1	+	12	1267	c.1056C>T	c.(1054-1056)ATC>ATT	p.I352I	PRPSAP2_uc002guo.1_Silent_p.I266I|PRPSAP2_uc010vyi.1_Silent_p.I300I|PRPSAP2_uc010vyj.1_Silent_p.I266I|PRPSAP2_uc010vyk.1_Silent_p.I291I|PRPSAP2_uc002guq.1_Silent_p.I139I	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	352					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1						TCCGTCGGATCCACAATGGGG	0.458													12	23					0	0	0	0	T	18833957	T	T	18833957	2	4	211	1	0	0	0	0	0	0	0	1	12644	845	30	2		2	PRPSAP2	17	18833957	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	1434663	18833957	62361253	174	38563											
CYTSB	92521	broad.mit.edu	37	chr17	20108048	20108048	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaacctatgataagagctcTtgaggagaagaacaagaact	17	7	11	6	0	1	6	0	2	1	4	1	8	1	7	1	2	4	1	1	2	7	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:20108048T>C	uc002gwq.2	+	4	831	c.686T>C	c.(685-687)CTT>CCT	p.L229P	CYTSB_uc010cqx.2_Missense_Mutation_p.L229P|CYTSB_uc002gwr.2_Missense_Mutation_p.L229P|CYTSB_uc002gws.2_Missense_Mutation_p.L229P|CYTSB_uc002gwv.2_Missense_Mutation_p.L148P|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Missense_Mutation_p.L5P|CYTSB_uc002gwt.2_Missense_Mutation_p.L148P|CYTSB_uc002gwu.2_Missense_Mutation_p.L148P	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	229						nucleus					0						ATAAGAGCTCTTGAGGAGAAG	0.478													33	153					0	0	0	0	C	20108048	C	C	20108048	3	2	211	1	0	0	0	0	1	0	0	0	4227	1609	56	5	740	5	CYTSB	17	20108048	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	1274091	20108048	61087162	175	38564											
SEZ6	124925	broad.mit.edu	37	chr17	27283247	27283247	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaggggcgggggcgggggCggggcagctgcagggagctt	4	5	25	7	3	0	0	0	0	0	0	0	1	0	1	0	9	3	5	0	9	1	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:27283247C>G	uc002hdp.2	-	16	3076	c.2882G>C	c.(2881-2883)CGC>CCC	p.R961P	SEZ6_uc010crx.1_Intron|SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.R961P|SEZ6_uc002hdq.1_Missense_Mutation_p.R836P	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	961	Cytoplasmic (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			ggggcgggggcggggCAGCTG	0.478													3	13					0	0	0	0	G	27283247	G	G	27283247	3	3	211	1	0	0	0	0	1	0	0	0	14207	768	27	3	123	3	SEZ6	17	27283247	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	7175199	27283247	53911963	176	38565											
GGNBP2	79893	broad.mit.edu	37	chr17	34943490	34943490	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agacctcaggaaataccatgCacacagtgtttcaccgtgac	13	8	8	12	1	2	2	2	1	0	1	2	3	2	3	3	1	2	2	3	1	2	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:34943490C>T	uc002hnb.2	+	13	1954	c.1705C>T	c.(1705-1707)CAC>TAC	p.H569Y		NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	569					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		AAATACCATGCACACAGTGTT	0.463													14	64					0	0	0	0	T	34943490	T	T	34943490	3	4	211	1	0	0	0	0	1	0	0	0	6396	710	25	4	1751	4	GGNBP2	17	34943490	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	7660243	34943490	46251720	177	38566											
KRT25	147183	broad.mit.edu	37	chr17	38910653	38910653	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacttgagtctgaaatcaTcagctgtaagcctggcatta	11	13	8	9	0	3	2	2	2	1	0	3	2	3	2	1	1	3	3	1	1	4	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:38910653T>G	uc002hve.2	-	2	558	c.497A>C	c.(496-498)GAT>GCT	p.D166A		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	166	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				TCTGAAATCATCAGCTGTAAG	0.383													29	67					0	0	0	0	G	38910653	G	G	38910653	3	3	211	1	0	0	0	0	1	0	0	0	8501	1435	50	5	883	5	KRT25	17	38910653	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	3967163	38910653	42284557	178	38567											
PLEKHH3	79990	broad.mit.edu	37	chr17	40823110	40823111	+	Missense_Mutation	DNP	CC	GT	GT																															agcgcgaatgcgttgcggctCcgggccaagcccagccgccc																										TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:40823110_40823111CC>GT	uc002iau.2	-	9	1789_1790	c.1322_1323GG>AC	c.(1321-1323)CGG>CAC	p.R441H	PLEKHH3_uc010cyl.1_Intron|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Intron|PLEKHH3_uc002iaw.2_Missense_Mutation_p.R441H	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	441	FERM.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		CGTTGCGGCTCCGGGCCAAGCC	0.663													33	56					0	0	0	0	GT	40823111	GT	GT	40823110	3	3	211	1	0	0	0	0	1	0	0	0	12133	842	30	2	1078	2	PLEKHH3	17	40823110	Missense_Mutation	DNP	CC	TCGA-CV-6956-01A-21D-2012-08	1912457	40823110	40372100	179	38568											
MARCH10	162333	broad.mit.edu	37	chr17	60821758	60821758	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctcccctgggaaccggcaCctttgcaggccactgctgtt	5	10	11	15	1	0	0	0	0	0	0	1	1	1	1	5	3	4	5	5	3	1	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:60821758C>A	uc010ddr.2	-	5	752	c.514G>T	c.(514-516)GTG>TTG	p.V172L	MARCH10_uc002jag.3_Missense_Mutation_p.V172L|MARCH10_uc010dds.2_Missense_Mutation_p.V210L|MARCH10_uc002jah.2_Missense_Mutation_p.V171L	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	172							ligase activity|zinc ion binding				0						GGAACCGGCACCTTTGCAGGC	0.557													52	96					3.89483e-19	4.79641e-19	1	0	A	60821758	A	A	60821758	3	1	211	1	0	0	0	0	1	0	0	0	9352	507	18	4	1940	4	MARCH10	17	60821758	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	19998648	60821758	20373452	180	38569											
LIMD2	80774	broad.mit.edu	37	chr17	61776623	61776623	+	Frame_Shift_Del	DEL	G	-	-																															agccgggcacttacatgagaGggggtggcctgggcggctcc																										TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:61776623delG	uc002jbj.3	-	2	214	c.36delC	c.(34-36)CCCfs	p.P12fs	LIMD2_uc002jbk.3_5'UTR|LIMD2_uc002jbl.3_Frame_Shift_Del_p.P12fs	NM_030576	NP_085053	Q9BT23	LIMD2_HUMAN	LIM domain containing 2	12							zinc ion binding				0						TTACATGAGAGGGGGTGGCCT	0.682													---	---	---								-	61776623	-	-	61776623	7	5	211	1	0	1	0	1	0	0	0	0	8840	987	35	0	363	0	LIMD2	17	61776623	Frame_Shift_Del	DEL	G	TCGA-CV-6956-01A-21D-2012-08	954865	61776623	19418587	181	38570											
TEX2	55852	broad.mit.edu	37	chr17	62290905	62290905	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccgactcctgccgggaagTgtccgtggacagagacttga	9	8	13	11	3	0	2	0	1	0	1	3	6	3	4	4	2	1	0	4	2	1	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:62290905T>A	uc002jec.2	-	2	846	c.673A>T	c.(673-675)ACT>TCT	p.T225S	TEX2_uc002jed.2_Missense_Mutation_p.T225S|TEX2_uc002jee.2_Missense_Mutation_p.T225S	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	225					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TGCCGGGAAGTGTCCGTGGAC	0.532													41	58					0	0	0	0	A	62290905	A	A	62290905	3	1	211	1	0	0	0	0	1	0	0	0	15847	1696	59	5	2775	5	TEX2	17	62290905	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	514282	62290905	18904305	182	38571											
SLC16A6	9120	broad.mit.edu	37	chr17	66267356	66267356	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agactaatgcccagaggaatGatgtacaaggaaggtgcaaa	17	6	12	6	0	0	3	0	1	0	2	0	5	0	5	1	3	3	2	1	3	6	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr17:66267356G>A	uc002jgz.1	-	5	1133	c.945C>T	c.(943-945)ATC>ATT	p.I315I	ARSG_uc002jhc.2_Intron|SLC16A6_uc002jha.1_Silent_p.I315I	NM_004694	NP_004685	O15403	MOT7_HUMAN	solute carrier family 16, member 6	315	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity				0	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	CCAGAGGAATGATGTACAAGG	0.423													12	24					0	0	0	0	A	66267356	A	A	66267356	2	1	211	1	0	0	0	0	0	0	0	1	14477	1280	45	2		2	SLC16A6	17	66267356	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	3976451	66267356	14927854	183	38572											
PYCR1	5831	broad.mit.edu	37	chr17	79892538	79892538	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacacactgaccaggagggcCtgggccccgaggcggactgc	9	3	15	14	2	0	1	0	1	0	0	0	4	0	3	4	5	2	0	4	5	1	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	e0a52d9d-41f2-46d3-8c62-df1241806397	g.chr17:79892538C>T	uc002kcr.1	-	5	902	c.624G>A	c.(622-624)CAG>CAA	p.Q208Q	PYCR1_uc002kcq.1_Silent_p.Q208Q|PYCR1_uc002kcp.2_Silent_p.Q208Q|PYCR1_uc002kcs.1_Silent_p.Q208Q|PYCR1_uc010wvd.1_Silent_p.Q235Q|PYCR1_uc002kct.1_Silent_p.Q208Q|PYCR1_uc002kcu.1_Intron|PYCR1_uc010wve.1_Intron	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	208					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	CCAGGAGGGCCTGGGCCCCGA	0.662													3	5					0	0	0	0	T	79892538	T	T	79892538	2	4	211	1	0	0	0	0	0	0	0	1	12920	680	24	4		4	PYCR1	17	79892538	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	13625182	79892538	1302672	184	38573											
MC5R	4161	broad.mit.edu	37	chr18	13826439	13826439	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgcggctctgcccggggcCagctctgcgcggcagaggac	5	5	16	15	5	2	1	0	0	2	1	3	2	2	2	2	5	3	3	2	5	0	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr18:13826439C>A	uc010xaf.1	+	1	675	c.675C>A	c.(673-675)GCC>GCA	p.A225A		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	225	Cytoplasmic (Potential).			ALPGASSARQRTSM -> LCPGPALRGRGPAW (in Ref. 1).	G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						TGCCCGGGGCCAGCTCTGCGC	0.622													87	179					3.56499e-28	4.45205e-28	1	0	A	13826439	A	A	13826439	2	1	211	1	0	0	0	0	0	0	0	1	9420	581	21	4		4	MC5R	18	13826439	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08		13826439	64250809	185	38574											
ZNF521	25925	broad.mit.edu	37	chr18	22807174	22807174	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcatcttccagtcctccatCctggaaccggactgagagcc	8	10	8	15	1	2	1	1	1	1	1	6	4	6	3	6	2	2	0	6	2	1	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr18:22807174C>T	uc002kvk.2	-	4	955	c.708G>A	c.(706-708)AGG>AGA	p.R236R	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.R236R|ZNF521_uc002kvl.2_Silent_p.R16R	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	236					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGTCCTCCATCCTGGAACCGG	0.522			T	PAX5	ALL								13	67					0	0	0	0	T	22807174	T	T	22807174	2	4	211	1	0	0	0	0	0	0	0	1	18032	854	30	2		2	ZNF521	18	22807174	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	8980735	22807174	55270074	186	38575											
NARS	4677	broad.mit.edu	37	chr18	55283091	55283091	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctcttcatttgttccctatgCcacatctttttaatgttctt	6	21	3	11	0	4	0	1	0	3	0	5	0	5	0	2	0	1	2	2	0	2	9			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr18:55283091C>A	uc002lgs.2	-	3	438	c.210G>T	c.(208-210)TGG>TGT	p.W70C	NARS_uc002lgt.2_Missense_Mutation_p.W69C|NARS_uc010xea.1_5'UTR|NARS_uc010xeb.1_RNA|NARS_uc010xec.1_Missense_Mutation_p.W70C|NARS_uc010xed.1_Missense_Mutation_p.W37C	NM_004539	NP_004530	O43776	SYNC_HUMAN	asparaginyl-tRNA synthetase	70					asparaginyl-tRNA aminoacylation	cytosol|soluble fraction	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding				0		Colorectal(73;0.227)			L-Asparagine(DB00174)	GTTCCCTATGCCACATCTTTT	0.388													22	55					1.87028e-06	2.0473e-06	1	0	A	55283091	A	A	55283091	3	1	211	1	0	0	0	0	1	0	0	0	10223	740	26	4	1484	4	NARS	18	55283091	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	32475917	55283091	22794157	187	38576											
LRG1	116844	broad.mit.edu	37	chr19	4538051	4538051	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatcttgtctttttgggcCtgaagccaacgatagaggtc	10	12	10	9	1	2	2	0	1	2	1	3	3	2	2	2	2	3	0	2	2	4	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:4538051C>T	uc002mau.2	-	2	956	c.945G>A	c.(943-945)CAG>CAA	p.Q315Q	PLIN5_uc002mas.2_5'Flank|PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	315	LRRCT.					extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTTTTGGGCCTGAAGCCAAC	0.592													40	35					0	0	0	0	T	4538051	T	T	4538051	2	4	211	1	0	0	0	0	0	0	0	1	8992	680	24	4		4	LRG1	19	4538051	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08		4538051	54590932	188	38577											
MUC16	94025	broad.mit.edu	37	chr19	9088493	9088493	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttaaatgatagacatcatCagaaaatgtgtcaacgaatt	17	12	7	5	1	3	3	3	1	0	2	3	4	3	3	0	0	1	1	0	0	7	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:9088493C>G	uc002mkp.2	-	1	3526	c.3322G>C	c.(3322-3324)GAT>CAT	p.D1108H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1108	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAGACATCATCAGAAAATGTG	0.443													18	36					0	0	0	0	G	9088493	G	G	9088493	3	3	211	1	0	0	0	0	1	0	0	0	10026	826	29	2	40537	2	MUC16	19	9088493	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	4550442	9088493	50040490	189	38578											
PPAN-P2RY11	692312	broad.mit.edu	37	chr19	10225320	10225320	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacagggacagctggaaccCagaggacgccaagagcactg	13	3	13	12	1	0	2	0	0	0	2	0	5	0	5	2	3	4	2	2	3	3	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:10225320C>G	uc002mna.2	+	13	2291	c.2291C>G	c.(2290-2292)CCA>CGA	p.P764R	PPAN-P2RY11_uc010xla.1_3'UTR|P2RY11_uc002mnc.2_Missense_Mutation_p.P344R	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	Error:Variant_position_missing_in_Q9NQ55_after_alignment					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			AGCTGGAACCCAGAGGACGCC	0.657													14	50					0	0	0	0	G	10225320	G	G	10225320	3	3	211	1	0	0	0	0	1	0	0	0	12344	594	21	4		4	PPAN-P2RY11	19	10225320	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	1136827	10225320	48903663	190	38579											
ZNF763	284390	broad.mit.edu	37	chr19	12088200	12088200	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttagggaaaaagtggaaaGaccagaacattgaatatgag	18	9	11	3	0	0	4	0	2	0	2	0	6	0	6	1	2	1	0	1	2	7	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:12088200G>T	uc002msw.2	+	3	300	c.145G>T	c.(145-147)GAC>TAC	p.D49Y	ZNF763_uc010xmf.1_Missense_Mutation_p.D69Y|ZNF763_uc002msv.2_Missense_Mutation_p.D52Y|ZNF763_uc010xmg.1_Intron	NM_001012753	NP_001012771	Q0D2J5	ZN763_HUMAN	zinc finger protein 763	49	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						AAAGTGGAAAGACCAGAACAT	0.333													18	32					2.35188e-11	2.70823e-11	1	0	T	12088200	T	T	12088200	3	4	211	1	0	0	0	0	1	0	0	0	18204	942	33	2	164	2	ZNF763	19	12088200	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	1862880	12088200	47040783	191	38580											
SYDE1	85360	broad.mit.edu	37	chr19	15222125	15222125	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctctcttcccacccccaggTagtgggactgtaccgtcttt	5	13	8	15	1	3	0	0	0	3	0	5	1	4	1	4	2	1	2	4	2	2	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:15222125T>C	uc002nah.1	+	5	1323	c.1292T>C	c.(1291-1293)GTA>GCA	p.V431A	SYDE1_uc002nai.1_Missense_Mutation_p.V364A|SYDE1_uc002naj.1_Missense_Mutation_p.V88A	NM_033025	NP_149014	Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1	431	Rho-GAP.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|pancreas(1)	2						CACCCCCAGGTAGTGGGACTG	0.587													33	22					0	0	0	0	C	15222125	C	C	15222125	3	2	211	1	0	0	0	0	1	0	0	0	15501	1652	57	5	1310	5	SYDE1	19	15222125	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	3133925	15222125	43906858	192	38581											
ATP13A1	57130	broad.mit.edu	37	chr19	19766741	19766741	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacgcacccgctgtcaacCgctggggagagaagcagagt	10	4	14	13	3	1	2	1	0	0	2	1	4	1	3	3	2	2	4	3	2	2	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:19766741C>G	uc002nnh.3	-	9	1243	c.1215G>C	c.(1213-1215)CCG>CCC	p.P405P	ATP13A1_uc002nnf.3_5'Flank|ATP13A1_uc002nng.2_Silent_p.P287P	NM_020410	NP_065143	Q9HD20	AT131_HUMAN	ATPase type 13A1	405	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding	p.?(1)		ovary(3)|large_intestine(2)|central_nervous_system(1)	6						CGCTGTCAACCGCTGGGGAGA	0.652													4	16					0	0	0	0	G	19766741	G	G	19766741	2	3	211	1	0	0	0	0	0	0	0	1	1125	666	23	3		3	ATP13A1	19	19766741	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	4544616	19766741	39362242	193	38582											
APLP1	333	broad.mit.edu	37	chr19	36368688	36368688	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcccctgggggcagcagcGaggacaagggtgggctgcag	7	4	19	11	1	0	0	0	0	0	0	0	2	0	1	2	5	4	4	2	5	1	0	rs142258705		TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:36368688G>A	uc002oce.2	+	12	1651	c.1513G>A	c.(1513-1515)GAG>AAG	p.E505K	APLP1_uc010xsz.1_Missense_Mutation_p.E466K|APLP1_uc002ocf.2_Missense_Mutation_p.E505K|APLP1_uc002ocg.2_Missense_Mutation_p.E408K|APLP1_uc010xta.1_Missense_Mutation_p.E499K	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	505	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGGCAGCAGCGAGGACAAGGG	0.582													17	44					0	0	0	0	A	36368688	A	A	36368688	3	1	211	1	0	0	0	0	1	0	0	0	778	1059	37	1	1559	1	APLP1	19	36368688	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	16601947	36368688	22760295	194	38583											
ZNF571	51276	broad.mit.edu	37	chr19	38057174	38057174	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctggagataactttttggtCacacaactggattccaagtc	11	13	8	9	0	2	1	1	0	1	1	4	3	3	2	1	3	2	0	1	3	3	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:38057174C>T	uc002ogt.2	-	4	257	c.156G>A	c.(154-156)GTG>GTA	p.V52V	uc002ogm.2_Intron|uc002ogn.2_Intron|ZNF540_uc002ogo.2_Intron|ZNF540_uc002ogp.2_Intron|ZNF540_uc002ogq.2_Intron|ZNF571_uc002ogr.1_Intron|uc002ogs.1_5'Flank|ZNF571_uc010efp.2_Silent_p.V52V	NM_016536	NP_057620	Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACTTTTTGGTCACACAACTGG	0.338													16	51					0	0	0	0	T	38057174	T	T	38057174	2	4	211	1	0	0	0	0	0	0	0	1	18070	813	29	2		2	ZNF571	19	38057174	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	1688486	38057174	21071809	195	38584											
PSG6	5675	broad.mit.edu	37	chr19	43529018	43529018	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatatataattatttgaccGtctactacatatgatgtaat	14	16	4	7	1	1	2	0	2	1	0	1	2	1	2	2	0	2	1	2	0	8	9	rs138426313		TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:43529018G>A	uc002ovh.1	-	2	362	c.273C>T	c.(271-273)GAC>GAT	p.D91D	PSG11_uc002ouw.2_Silent_p.D91D|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Silent_p.D91D|PSG11_uc002ovm.1_Silent_p.D85D|PSG11_uc002ovn.1_Silent_p.D91D|PSG11_uc002ovo.1_Intron|PSG11_uc002ovp.1_Intron			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				TTATTTGACCGTCTACTACAT	0.443													56	179					0	0	0	0	A	43529018	A	A	43529018	2	1	211	1	0	0	0	0	0	0	0	1	12721	1136	40	1		1	PSG6	19	43529018	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	5471844	43529018	15599965	196	38585											
TEX101	83639	broad.mit.edu	37	chr19	43920656	43920656	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actactgtgaggattccttcTgtaatgacaaagacagcctg	12	11	9	9	0	1	3	0	2	1	1	2	4	2	4	2	1	2	1	2	1	3	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:43920656T>C	uc010xwo.1	+	4	535	c.340T>C	c.(340-342)TGT>CGT	p.C114R	TEX101_uc002owk.2_Missense_Mutation_p.C132R	NM_001130011	NP_001123483	Q9BY14	TX101_HUMAN	testis expressed 101 isoform 2	114						anchored to membrane|plasma membrane				ovary(1)	1		Prostate(69;0.0199)				GGATTCCTTCTGTAATGACAA	0.507													98	142					0	0	0	0	C	43920656	C	C	43920656	3	2	211	1	0	0	0	0	1	0	0	0	15839	1580	55	5	408	5	TEX101	19	43920656	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	391638	43920656	15208327	197	38586											
FOSB	2354	broad.mit.edu	37	chr19	45971882	45971882	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cggagactacgactccggctCccggtgcagctcctcaccct	6	7	10	18	4	1	1	1	0	0	1	4	3	4	1	4	3	3	3	4	3	1	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:45971882C>T	uc002pbx.3	+	1	630	c.38C>T	c.(37-39)TCC>TTC	p.S13F	ERCC1_uc002pbu.1_Intron|FOSB_uc002pbw.2_Missense_Mutation_p.S13F|FOSB_uc010eke.2_Missense_Mutation_p.S13F|FOSB_uc002pby.3_Missense_Mutation_p.S13F|FOSB_uc010eka.1_Missense_Mutation_p.S13F|FOSB_uc010ekb.1_Missense_Mutation_p.S13F|FOSB_uc010ekc.1_Missense_Mutation_p.S13F|FOSB_uc010ekf.2_Missense_Mutation_p.S13F|FOSB_uc010ekd.1_Missense_Mutation_p.S13F|FOSB_uc010ekg.2_Missense_Mutation_p.S13F|FOSB_uc002pca.3_5'Flank	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	13					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		GACTCCGGCTCCCGGTGCAGC	0.632													56	66					0	0	0	0	T	45971882	T	T	45971882	3	4	211	1	0	0	0	0	1	0	0	0	6018	855	30	2	40	2	FOSB	19	45971882	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	2051226	45971882	13157101	198	38587											
RUVBL2	10856	broad.mit.edu	37	chr19	49497072	49497072	+	5'Flank	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acatatttatgaggaaccatCgagatctttgaagaaccagc	15	10	8	8	1	1	4	0	2	1	2	2	6	1	5	2	1	3	0	2	1	5	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:49497072C>G	uc002plr.1	+						GYS1_uc010xzy.1_5'Flank|GYS1_uc002plp.2_5'Flank|GYS1_uc010emm.2_5'Flank|GYS1_uc010xzz.1_5'Flank|GYS1_uc010yaa.1_5'Flank|RUVBL2_uc002plq.1_Translation_Start_Site|RUVBL2_uc010yab.1_5'Flank|RUVBL2_uc002pls.1_5'Flank|RUVBL2_uc010emn.1_5'Flank|RUVBL2_uc010yac.1_5'Flank	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2						cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		GAGGAACCATCGAGATCTTTG	0.572													3	15					0	0	0	0	G	49497072	G	G	49497072	1	3	211	0	1	0	0	0	0	0	0	0	13818	899	31	3		3	RUVBL2	19	49497072	5'Flank	SNP	C	TCGA-CV-6956-01A-21D-2012-08	3525190	49497072	9631911	199	38588											
ZNF347	84671	broad.mit.edu	37	chr19	53644866	53644866	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgagtgaagaccttgccacaTtcattacatttgtaaggttt	11	15	8	7	0	1	3	1	2	0	1	1	3	1	3	2	1	2	2	2	1	3	6			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:53644866T>A	uc002qbb.1	-	5	1284	c.1215A>T	c.(1213-1215)GAA>GAT	p.E405D	ZNF347_uc010eql.1_Missense_Mutation_p.E406D|ZNF347_uc002qbc.1_Missense_Mutation_p.E406D	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	405	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		CCTTGCCACATTCATTACATT	0.423													42	60					0	0	0	0	A	53644866	A	A	53644866	3	1	211	1	0	0	0	0	1	0	0	0	17928	1490	52	5	1308	5	ZNF347	19	53644866	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	4147794	53644866	5484117	200	38589											
LENG9	94059	broad.mit.edu	37	chr19	54973750	54973750	+	Frame_Shift_Del	DEL	T	-	-																															ggggccacgtggaccaggtaTtcctgggccttggtcacttc																										TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:54973750delT	uc010yez.1	-	1	1145	c.1026delA	c.(1024-1026)GAAfs	p.E342fs		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	342					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		GGACCAGGTATTCCTGGGCCT	0.632													---	---	---								-	54973750	-	-	54973750	7	5	211	1	0	1	0	1	0	0	0	0	8765	1490	52	0	483	0	LENG9	19	54973750	Frame_Shift_Del	DEL	T	TCGA-CV-6956-01A-21D-2012-08	1328884	54973750	4155233	201	38590											
NLRP11	204801	broad.mit.edu	37	chr19	56303779	56303779	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgtcttagagttgggctgaAcagaagcactcttccaaggg	10	11	12	8	0	2	3	0	1	2	2	3	3	3	3	1	2	2	3	1	2	4	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:56303779A>G	uc010ygf.1	-	9	3112	c.2401T>C	c.(2401-2403)TTC>CTC	p.F801L	NLRP11_uc002qlz.2_Missense_Mutation_p.F648L|NLRP11_uc002qmb.2_Missense_Mutation_p.F702L|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	801							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		GTTGGGCTGAACAGAAGCACT	0.473													9	78					0	0	0	0	G	56303779	G	G	56303779	3	3	211	1	0	0	0	0	1	0	0	0	10527	43	2	5	716	5	NLRP11	19	56303779	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08	1330029	56303779	2825204	202	38591											
ZNF71	58491	broad.mit.edu	37	chr19	57133864	57133864	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcatcgtgcaccagatcgtGcacaccggggagaagcccta	10	6	11	14	3	1	2	1	0	0	2	3	3	1	2	3	2	3	2	3	2	2	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:57133864G>T	uc002qnm.3	+	3	1447	c.1209G>T	c.(1207-1209)GTG>GTT	p.V403V		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	403	C2H2-type 10.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		ACCAGATCGTGCACACCGGGG	0.647													15	47					8.60227e-14	1.00802e-13	1	0	T	57133864	T	T	57133864	2	4	211	1	0	0	0	0	0	0	0	1	18181	1306	46	4		4	ZNF71	19	57133864	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	830085	57133864	1995119	203	38592											
ZNF211	10520	broad.mit.edu	37	chr19	58132578	58132578	+	Translation_Start_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgactatattgcacaccagaGggttcacactggtgaaaggc	12	9	11	9	0	1	3	1	2	0	1	1	3	1	3	1	3	1	2	1	3	3	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr19:58132578G>T	uc010yhb.1	+	1	785	c.-322G>T	c.(-324--320)GAGGG>GATGG		ZNF134_uc002qpo.2_Missense_Mutation_p.R191M|ZNF134_uc002qpn.2_Missense_Mutation_p.R364M	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCACACCAGAGGGTTCACACT	0.438													39	36					2.51541e-25	3.12663e-25	1	0	T	58132578	T	T	58132578	1	4	211	1	0	0	0	0	0	0	0	0	17834	1000	35	4		4	ZNF211	19	58132578	Translation_Start_Site	SNP	G	TCGA-CV-6956-01A-21D-2012-08	998714	58132578	996405	204	38593											
PTPRA	5786	broad.mit.edu	37	chr20	2845938	2845938	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgtgcagagcagctggcaCgtgacttccgcatccctgac	8	7	12	14	3	0	3	0	2	0	1	2	3	2	3	2	1	4	5	2	1	0	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr20:2845938C>T	uc002whj.2	+	5	522	c.-153C>T	c.(-155--151)CACGT>CATGT		VPS16_uc002whh.2_RNA|VPS16_uc002whe.2_Missense_Mutation_p.R717C|VPS16_uc002whf.2_Missense_Mutation_p.R573C|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Missense_Mutation_p.R403C|VPS16_uc002whi.2_Missense_Mutation_p.R201C	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A						axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						GCAGCTGGCACGTGACTTCCG	0.592													23	60					0	0	0	0	T	2845938	T	T	2845938	1	4	211	1	0	0	0	0	0	0	0	0	12860	536	19	1		1	PTPRA	20	2845938	Translation_Start_Site	SNP	C	TCGA-CV-6956-01A-21D-2012-08		2845938	60179582	205	38594											
ProSAPiP1	9762	broad.mit.edu	37	chr20	3147717	3147717	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatggccaggcgggggtcCgggggtccaagctcggaggg	5	4	20	12	3	0	0	0	0	0	0	3	1	2	1	4	8	1	1	4	8	1	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr20:3147717C>T	uc002wia.1	-	1	1491	c.93G>A	c.(91-93)CCG>CCA	p.P31P	ProSAPiP1_uc002wib.1_Silent_p.P31P	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	31						cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						GGCGGGGGTCCGGGGGTCCAA	0.706													9	10					0	0	0	0	T	3147717	T	T	3147717	2	4	211	1	0	0	0	0	0	0	0	1	12935	639	23	1		1	ProSAPiP1	20	3147717	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08	301779	3147717	59877803	206	38595											
RIN2	54453	broad.mit.edu	37	chr20	19981537	19981537	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catcaagaacgatccttatgGcatcattttccagaacgggg	12	10	9	10	2	2	2	2	0	0	2	4	3	4	2	2	3	2	1	2	3	4	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr20:19981537G>T	uc002wro.1	+	11	2681	c.2645G>T	c.(2644-2646)GGC>GTC	p.G882V	RIN2_uc010gcu.1_Missense_Mutation_p.G449V|RIN2_uc010gcv.1_Missense_Mutation_p.G676V	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	882					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						GATCCTTATGGCATCATTTTC	0.532													22	63					5.45024e-15	6.47216e-15	1	0	T	19981537	T	T	19981537	3	4	211	1	0	0	0	0	1	0	0	0	13437	1203	42	4	2687	4	RIN2	20	19981537	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	16833820	19981537	43043983	207	38596											
CST3	1471	broad.mit.edu	37	chr20	23614554	23614554	+	Nonstop_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccagcccggtacagaccccTaggcgtcctgacaggtggat	8	6	13	14	2	0	2	0	1	0	1	1	3	1	3	5	4	2	1	5	4	2	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr20:23614554T>A	uc002wtm.2	-	3	515	c.440A>T	c.(439-441)TAG>TTG	p.*147L	CST3_uc002wtn.1_Nonstop_Mutation_p.*147L	NM_000099	NP_000090	P01034	CYTC_HUMAN	cystatin C precursor	147					defense response|fibril organization|negative regulation of blood vessel remodeling|negative regulation of collagen catabolic process|negative regulation of elastin catabolic process|negative regulation of extracellular matrix disassembly	extracellular space	beta-amyloid binding|cysteine-type endopeptidase inhibitor activity|protease binding			ovary(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					TACAGACCCCTAGGCGTCCTG	0.577													31	97					0	0	0	0	A	23614554	A	A	23614554	4	1	211	1	0	0	0	0	0	0	0	0	3990	1535	53	5	4	5	CST3	20	23614554	Nonstop_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	3633017	23614554	39410966	208	38597											
BAGE2	85319	broad.mit.edu	37	chr21	11058238	11058238	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgaaaggtgtcggctcctGcagcacaaggataatgatac	12	8	11	10	1	0	2	0	2	0	0	2	3	1	3	2	3	3	3	2	3	4	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr21:11058238G>A	uc002yit.1	-	3	410	c.202C>T	c.(202-204)CAG>TAG	p.Q68*	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTCGGCTCCTGCAGCACAAGG	0.433													14	83					0	0	0	0	A	11058238	A	A	11058238	4	1	211	1	0	0	0	0	0	1	0	0	1294	1328	46	4	135	4	BAGE2	21	11058238	Nonsense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08		11058238	37071657	209	38598											
NRIP1	8204	broad.mit.edu	37	chr21	16339770	16339770	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtggcaggactagcccttttTtccaccatgcttgcaacagc	8	11	9	13	0	0	0	0	0	0	0	1	1	1	1	3	2	5	3	3	2	2	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr21:16339770T>A	uc002yjx.2	-	4	1342	c.744A>T	c.(742-744)GAA>GAT	p.E248D		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	248	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TAGCCCTTTTTTCCACCATGC	0.473													19	47					0	0	0	0	A	16339770	A	A	16339770	3	1	211	1	0	0	0	0	1	0	0	0	10706	1838	64	5	2736	5	NRIP1	21	16339770	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	5281532	16339770	31790125	210	38599											
TRAPPC10	7109	broad.mit.edu	37	chr21	45479008	45479008	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttgcctttgttttcgagAtgctgcagcagttcgaggac	7	13	12	9	2	0	1	0	0	0	1	2	4	0	2	1	1	5	6	1	1	0	5			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr21:45479008A>T	uc002zea.2	+	6	872	c.703A>T	c.(703-705)ATG>TTG	p.M235L	TRAPPC10_uc010gpo.2_5'UTR|TRAPPC10_uc002zdz.2_Missense_Mutation_p.M235L	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	235					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TGTTTTCGAGATGCTGCAGCA	0.468													9	28					0	0	0	0	T	45479008	T	T	45479008	3	4	211	1	0	0	0	0	1	0	0	0	16524	333	12	5	725	5	TRAPPC10	21	45479008	Missense_Mutation	SNP	A	TCGA-CV-6956-01A-21D-2012-08	29139238	45479008	2650887	211	38600											
SYN3	8224	broad.mit.edu	37	chr22	32909744	32909744	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtttcagccttggcctcgtCttcacttggggtcccacgct	3	13	11	14	2	3	0	2	0	1	0	5	0	4	0	3	4	1	2	3	4	0	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr22:32909744C>G	uc003amx.2	-	13	1837	c.1678G>C	c.(1678-1680)GAC>CAC	p.D560H	SYN3_uc003amy.2_3'UTR|SYN3_uc003amz.2_Missense_Mutation_p.D559H	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	560	E.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						TTGGCCTCGTCTTCACTTGGG	0.562													28	55					0	0	0	0	G	32909744	G	G	32909744	3	3	211	1	0	0	0	0	1	0	0	0	15508	913	32	2	68	2	SYN3	22	32909744	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08		32909744	18394822	212	38601											
GRAP2	9402	broad.mit.edu	37	chr22	40364132	40364132	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaaatccgaccttcgatGaaccggaagctgtcggatca	13	7	11	10	4	1	2	1	1	0	1	4	7	2	4	3	2	2	1	3	2	4	1			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr22:40364132G>T	uc003ayh.1	+	6	809	c.546G>T	c.(544-546)ATG>ATT	p.M182I	GRAP2_uc003ayi.2_RNA|GRAP2_uc011aom.1_Missense_Mutation_p.M156I|GRAP2_uc011aon.1_Missense_Mutation_p.M116I|GRAP2_uc010gya.1_Missense_Mutation_p.M182I|GRAP2_uc011aoo.1_Missense_Mutation_p.M110I|GRAP2_uc011aop.1_Missense_Mutation_p.M142I|GRAP2_uc011aoq.1_Missense_Mutation_p.M69I|GRAP2_uc003ayj.1_Missense_Mutation_p.M182I	NM_004810	NP_004801	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	182					cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GACCTTCGATGAACCGGAAGC	0.443													8	10					0.00448238	0.0047127	1	0	T	40364132	T	T	40364132	3	4	211	1	0	0	0	0	1	0	0	0	6793	1290	45	2	564	2	GRAP2	22	40364132	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	7454388	40364132	10940434	213	38602											
PHF21B	112885	broad.mit.edu	37	chr22	45281799	45281799	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcatcccagtccagggcacaCcctcgtctttctttaaggcc	7	10	8	16	1	2	0	0	0	2	0	5	0	4	0	4	2	0	2	4	2	1	3			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr22:45281799C>T	uc003bfn.2	-	11	1368	c.1217G>A	c.(1216-1218)GGT>GAT	p.G406D	PHF21B_uc003bfm.2_Missense_Mutation_p.G202D|PHF21B_uc011aqk.1_Missense_Mutation_p.G352D|PHF21B_uc011aql.1_Missense_Mutation_p.G364D	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	406							zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		CCAGGGCACACCCTCGTCTTT	0.597													57	84					0	0	0	0	T	45281799	T	T	45281799	3	4	211	1	0	0	0	0	1	0	0	0	11889	507	18	4	390	4	PHF21B	22	45281799	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	4917667	45281799	6022767	214	38603											
CELSR1	9620	broad.mit.edu	37	chr22	46931727	46931727	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgttctcgtcctccacctcGatgtacacggtggccgtggc	4	11	11	15	5	1	0	0	0	1	0	6	1	3	0	4	3	1	2	4	3	1	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chr22:46931727G>T	uc003bhw.1	-	1	1341	c.1341C>A	c.(1339-1341)ATC>ATA	p.I447I		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	447	Extracellular (Potential).|Cadherin 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCTCCACCTCGATGTACACGG	0.667													16	35					1.52009e-12	1.75802e-12	1	0	T	46931727	T	T	46931727	2	4	211	1	0	0	0	0	0	0	0	1	3236	1048	37	3		3	CELSR1	22	46931727	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	1649928	46931727	4372839	215	38604											
NR0B1	190	broad.mit.edu	37	chrX	30327172	30327172	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcacgaacagccccagcaCggacccagcgtcgcctcggg	8	2	12	19	6	0	0	0	0	0	0	2	2	0	1	5	2	4	2	5	2	1	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chrX:30327172C>A	uc004dcf.3	-	1	324	c.309G>T	c.(307-309)CCG>CCT	p.P103P		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	103	4 X 67 AA tandem repeats.|2.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	AGCCCCAGCACGGACCCAGCG	0.677											OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	15					2.37509e-13	2.75884e-13	1	0	A	30327172	A	A	30327172	2	1	211	1	0	0	0	0	0	0	0	1	10667	523	19	3		3	NR0B1	23	30327172	Silent	SNP	C	TCGA-CV-6956-01A-21D-2012-08		30327172	124943388	216	38605											
DCAF12L1	139170	broad.mit.edu	37	chrX	125686264	125686264	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggtgccgcacaccacctGcctggagttcagccactgtg	6	9	11	15	1	1	0	1	0	0	0	1	1	1	1	5	2	3	2	5	2	0	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chrX:125686264G>T	uc004eul.2	-	1	579	c.328C>A	c.(328-330)CAG>AAG	p.Q110K		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	110										skin(3)|ovary(1)	4						CACACCACCTGCCTGGAGTTC	0.637													36	17					4.65686e-17	5.65628e-17	1	0	T	125686264	T	T	125686264	3	4	211	1	0	0	0	0	1	0	0	0	4281	1328	46	4	1067	4	DCAF12L1	23	125686264	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	95359092	125686264	29584296	217	38606											
SMARCA1	6594	broad.mit.edu	37	chrX	128599869	128599869	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atccttcgttgaattcttgcTtctccacgttcaatttgagc	7	17	6	11	2	3	2	1	2	2	0	6	2	4	2	2	0	2	3	2	0	2	7			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chrX:128599869T>G	uc004eun.3	-	22	2882	c.2769A>C	c.(2767-2769)GAA>GAC	p.E923D	SMARCA1_uc004eup.3_Missense_Mutation_p.E911D|SMARCA1_uc011muk.1_Missense_Mutation_p.E923D|SMARCA1_uc011mul.1_Missense_Mutation_p.E911D	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	923					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						GAATTCTTGCTTCTCCACGTT	0.333													29	21					0	0	0	0	G	128599869	G	G	128599869	3	3	211	1	0	0	0	0	1	0	0	0	14832	1606	56	5	407	5	SMARCA1	23	128599869	Missense_Mutation	SNP	T	TCGA-CV-6956-01A-21D-2012-08	2913605	128599869	26670691	218	38607											
GPC4	2239	broad.mit.edu	37	chrX	132438794	132438794	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caacagtcatcctcattgccGtttcctgcagccatcctctc	7	12	5	17	1	3	0	2	0	1	0	7	0	6	0	5	0	4	2	5	0	1	2			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chrX:132438794G>A	uc004exc.1	-	7	1463	c.1251C>T	c.(1249-1251)AAC>AAT	p.N417N	GPC4_uc011mvg.1_Silent_p.N347N	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	417					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					CCTCATTGCCGTTTCCTGCAG	0.468													74	35					0	0	0	0	A	132438794	A	A	132438794	2	1	211	1	0	0	0	0	0	0	0	1	6638	1136	40	1		1	GPC4	23	132438794	Silent	SNP	G	TCGA-CV-6956-01A-21D-2012-08	3838925	132438794	22831766	219	38608											
GABRA3	2556	broad.mit.edu	37	chrX	151336735	151336735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catgcccttgatagctgactCccggttgacatatgtggccc	7	11	10	13	1	0	3	0	3	0	0	1	3	1	3	3	2	2	2	3	2	2	4			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chrX:151336735C>T	uc010ntk.1	-	10	1684	c.1444G>A	c.(1444-1446)GAG>AAG	p.E482K		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	482					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATAGCTGACTCCCGGTTGACA	0.498													35	13					0	0	0	0	T	151336735	T	T	151336735	3	4	211	1	0	0	0	0	1	0	0	0	6196	864	30	2	38	2	GABRA3	23	151336735	Missense_Mutation	SNP	C	TCGA-CV-6956-01A-21D-2012-08	18897941	151336735	3933825	220	38609											
ATP2B3	492	broad.mit.edu	37	chrX	152825277	152825277	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcgacggagccacccacaGagtcgctgctgctgcggaag	8	5	15	13	4	0	1	0	0	0	1	1	4	0	3	2	3	4	3	2	3	1	0			TCGA-CV-6956-01A-21D-2012-08	TCGA-CV-6956-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9ccee056-124e-40d5-a07d-c208765d8640	d28213c6-eb6f-4348-aca4-6f384a3b6d71	g.chrX:152825277G>A	uc004fht.1	+	16	2842	c.2716G>A	c.(2716-2718)GAG>AAG	p.E906K	ATP2B3_uc004fhs.1_Missense_Mutation_p.E906K|ATP2B3_uc010nuf.1_5'Flank|ATP2B3_uc004fhu.1_5'Flank	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	906	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCACCCACAGAGTCGCTGCT	0.597													35	11					0	0	0	0	A	152825277	A	A	152825277	3	1	211	1	0	0	0	0	1	0	0	0	1143	943	33	2	2778	2	ATP2B3	23	152825277	Missense_Mutation	SNP	G	TCGA-CV-6956-01A-21D-2012-08	1488542	152825277	2445283	221	38610											
C1orf135	79000	broad.mit.edu	37	chr1	26186959	26186960	+	5'Flank	INS	-	T	T																															cccggccaaaaattttgtaaINSttttttttttttggtggagg																										TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr1:26186959_26186960insT	uc001bkw.1	-							NM_024037	NP_076942	Q9H7T9	CA135_HUMAN	aurora A-binding protein												0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00521)|all_lung(284;0.00764)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.117)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.28e-25)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000787)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		AAATTTTGTAATTTTTTTTTTT	0.272													---	---	---								T	26186960	T	T	26186959	6	5	212	0	1	1	1	0	0	0	0	0	2008	116	4	0		0	C1orf135	1	26186959	5'Flank	INS	-	TCGA-CV-6959-01A-11D-1912-08		26186959	223063662	1	38611											
GPN2	54707	broad.mit.edu	37	chr1	27216255	27216255	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagagctccacctggcctggGcagtcgaagaggaagtagtg	10	6	15	10	1	0	2	0	0	0	2	2	4	1	3	3	3	1	3	3	3	3	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr1:27216255G>A	uc001bnd.1	-	1	615	c.333C>T	c.(331-333)TGC>TGT	p.C111C		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	111							GTP binding				0						CCTGGCCTGGGCAGTCGAAGA	0.657													17	88					0	0	0	0	A	27216255	A	A	27216255	2	1	212	1	0	0	0	0	0	0	0	1	6656	1195	42	4		4	GPN2	1	27216255	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08	1029296	27216255	222034366	2	38612											
NBPF10	100132406	broad.mit.edu	37	chr1	145365392	145365392	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cttgaactgtgtgactcatgCcagccctacagaagtgcctt	9	11	9	12	0	1	3	1	2	0	1	1	3	1	3	3	0	5	0	3	0	3	3			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr1:145365392C>G	uc001end.3	+	82	10277	c.10242C>G	c.(10240-10242)TGC>TGG	p.C3414W	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3339											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GTGACTCATGCCAGCCCTACA	0.478													13	89					0	0	0	0	G	145365392	G	G	145365392	3	3	212	1	0	0	0	0	1	0	0	0	10246	747	26	4	10335	4	NBPF10	1	145365392	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	118149137	145365392	103885229	3	38613											
CD247	919	broad.mit.edu	37	chr1	167409931	167409931	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaacaaggcagtgagaatGacaccatagatgaagaggat	18	5	13	5	0	0	5	0	3	0	3	0	8	0	7	1	3	1	1	1	3	5	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr1:167409931G>C	uc001gei.3	-	2	277	c.132C>G	c.(130-132)GTC>GTG	p.V44V	CD247_uc001gej.3_Silent_p.V44V|CD247_uc001gek.2_Silent_p.V44V	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	44	Helical; (Potential).				interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			CAGTGAGAATGACACCATAGA	0.557													6	40					0	0	0	0	C	167409931	C	C	167409931	2	2	212	1	0	0	0	0	0	0	0	1	3003	1277	45	2		2	CD247	1	167409931	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08	22044539	167409931	81840690	4	38614											
OR14C36	127066	broad.mit.edu	37	chr1	248513012	248513012	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attttttattcagaaaatgtGtaagaaacccgagaggctca	15	12	8	6	1	2	3	2	0	0	3	2	4	2	3	1	1	1	2	1	1	5	5			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr1:248513012G>A	uc010pzl.1	+	1	936	c.936G>A	c.(934-936)GTG>GTA	p.V312V		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CAGAAAATGTGTAAGAAACCC	0.333													17	73					0	0	0	0	A	248513012	A	A	248513012	2	1	212	1	0	0	0	0	0	0	0	1	11000	1391	48	4		4	OR14C36	1	248513012	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08	81103081	248513012	737609	5	38615											
OXER1	165140	broad.mit.edu	37	chr2	42991037	42991037	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagggccaggattggtgccaGgaaggcagacaccagcgagg	11	3	17	10	1	0	1	0	0	0	1	0	4	0	3	3	6	2	1	3	6	1	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr2:42991037G>C	uc002rss.2	-	1	365	c.283C>G	c.(283-285)CTG>GTG	p.L95V		NM_148962	NP_683765	Q8TDS5	OXER1_HUMAN	G-protein coupled receptor TG1019	95	Extracellular (Potential).				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)	1						ATTGGTGCCAGGAAGGCAGAC	0.532													8	52					0	0	0	0	C	42991037	C	C	42991037	3	2	212	1	0	0	0	0	1	0	0	0	11385	991	35	4	992	4	OXER1	2	42991037	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08		42991037	200208336	6	38616											
SEMA4F	10505	broad.mit.edu	37	chr2	74883756	74883756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacacactttatgttggcGcccgggacaccatcttcgct	7	10	8	16	3	1	0	0	0	1	0	2	1	1	1	3	2	0	2	3	2	1	4			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr2:74883756G>A	uc002sna.1	+	2	352	c.241G>A	c.(241-243)GCC>ACC	p.A81T	SEMA4F_uc010ysb.1_Missense_Mutation_p.A81T|SEMA4F_uc010ffq.1_Missense_Mutation_p.A81T|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Missense_Mutation_p.A81T	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	81	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TTATGTTGGCGCCCGGGACAC	0.577													23	107					0	0	0	0	A	74883756	A	A	74883756	3	1	212	1	0	0	0	0	1	0	0	0	14100	1087	38	1	247	1	SEMA4F	2	74883756	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	31892719	74883756	168315617	7	38617											
TSGA10	80705	broad.mit.edu	37	chr2	99695246	99695246	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caagaatgctgatttcttctCgctgtgcaatattttgcctt	8	17	7	9	1	2	2	0	1	2	1	3	2	2	2	1	0	3	3	1	0	4	6			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr2:99695246C>T	uc002szg.3	-	10	1386	c.758G>A	c.(757-759)CGA>CAA	p.R253Q	TSGA10_uc002szh.3_Missense_Mutation_p.R253Q|TSGA10_uc002szi.3_Missense_Mutation_p.R253Q|TSGA10_uc010fin.1_Missense_Mutation_p.R253Q|TSGA10_uc010yvn.1_Missense_Mutation_p.R253Q	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	253					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						GATTTCTTCTCGCTGTGCAAT	0.328													8	29					0	0	0	0	T	99695246	T	T	99695246	3	4	212	1	0	0	0	0	1	0	0	0	16684	884	31	1	1378	1	TSGA10	2	99695246	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	24811490	99695246	143504127	8	38618											
UXS1	80146	broad.mit.edu	37	chr2	106774513	106774513	+	Splice_Site	DEL	C	-	-																															tattcaggtgtgcaaacttaCcaaaattcttttccgatcct																										TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr2:106774513delC	uc002tdm.2	-	5	374	c.276_splice	c.e5+1	p.L92_splice	UXS1_uc002tdn.2_Splice_Site_p.L97_splice|UXS1_uc002tdo.2_Splice_Site_p.L35_splice|UXS1_uc010ywh.1_Intron	NM_025076	NP_079352	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1						cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2						TGCAAACTTACCAAAATTCTT	0.219													---	---	---								-	106774513	-	-	106774513	8	5	212	1	0	1	0	1	0	0	1	0	17177	521	18	0	1029	0	UXS1	2	106774513	Splice_Site	DEL	C	TCGA-CV-6959-01A-11D-1912-08	7079267	106774513	136424860	9	38619											
SH3RF3	344558	broad.mit.edu	37	chr2	110015235	110015235	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaagaagaacaccaagaaaCgccactccttcaccgcgctc	14	4	7	16	3	1	3	1	0	0	3	3	3	2	3	4	0	2	2	4	0	5	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr2:110015235C>T	uc010ywt.1	+	4	1135	c.1135C>T	c.(1135-1137)CGC>TGC	p.R379C		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	379							zinc ion binding			ovary(1)	1						CACCAAGAAACGCCACTCCTT	0.597													3	21					0	0	0	0	T	110015235	T	T	110015235	3	4	212	1	0	0	0	0	1	0	0	0	14325	536	19	1	1149	1	SH3RF3	2	110015235	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	3240722	110015235	133184138	10	38620											
THSD7B	80731	broad.mit.edu	37	chr2	138208533	138208533	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgagaattcgatccaaatgGctaaaagaaaaaccttacaa	19	8	7	7	1	0	2	0	1	0	2	2	4	1	2	2	1	2	1	2	1	8	3			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr2:138208533G>T	uc002tva.1	+	14	2985	c.2985G>T	c.(2983-2985)TGG>TGT	p.W995C	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GATCCAAATGGCTAAAAGAAA	0.413													7	33					2.0095e-06	2.6278e-06	1	0	T	138208533	T	T	138208533	3	4	212	1	0	0	0	0	1	0	0	0	15946	1212	42	4	3039	4	THSD7B	2	138208533	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	28193298	138208533	104990840	11	38621											
TTN	7273	broad.mit.edu	37	chr2	179599567	179599567	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaattgacaaaatacattcgGactgtgttactttcactgag	13	13	8	7	1	1	2	1	2	0	0	2	4	1	3	0	1	2	1	0	1	5	5			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr2:179599567G>A	uc010zfg.1	-	48	11576	c.11352C>T	c.(11350-11352)GTC>GTT	p.V3784V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.V445V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4711							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATACATTCGGACTGTGTTAC	0.418													9	74					0	0	0	0	A	179599567	A	A	179599567	2	1	212	1	0	0	0	0	0	0	0	1	16803	1161	41	2		2	TTN	2	179599567	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08	41391034	179599567	63599806	12	38622											
HECW2	57520	broad.mit.edu	37	chr2	197184307	197184307	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacccatggacctctcagagCaggtcgctgtccccggcctg	6	7	11	17	2	1	1	1	0	1	1	4	2	2	2	5	3	1	2	5	3	0	0			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr2:197184307C>A	uc002utm.1	-	9	1490	c.1307G>T	c.(1306-1308)TGC>TTC	p.C436F	HECW2_uc002utl.1_Missense_Mutation_p.C80F	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	436					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CCTCTCAGAGCAGGTCGCTGT	0.498													25	41					5.45024e-15	8.29738e-15	1	0	A	197184307	A	A	197184307	3	1	212	1	0	0	0	0	1	0	0	0	7082	710	25	4	3495	4	HECW2	2	197184307	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	17584740	197184307	46015066	13	38623											
SLC16A14	151473	broad.mit.edu	37	chr2	230911039	230911039	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcctgtgcccggcctgatcgGggcactcctgggcttgcagg	3	9	15	14	2	0	1	0	1	0	0	3	1	2	1	4	5	2	3	4	5	0	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr2:230911039G>T	uc002vqd.1	-	4	1166	c.803C>A	c.(802-804)CCC>CAC	p.P268H	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Missense_Mutation_p.P268H|SLC16A14_uc002vqf.2_Missense_Mutation_p.P268H	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	268	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		GGCCTGATCGGGGCACTCCTG	0.577													27	129					1.26454e-06	1.67511e-06	1	0	T	230911039	T	T	230911039	3	4	212	1	0	0	0	0	1	0	0	0	14472	1232	43	4	737	4	SLC16A14	2	230911039	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	33726732	230911039	12288334	14	38624											
CHL1	10752	broad.mit.edu	37	chr3	447203	447203	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgatgaaaagcctctcaaaGgaagccttcggtcccttaat	12	10	9	10	1	1	2	1	2	1	0	4	3	2	3	3	2	2	0	3	2	5	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr3:447203G>T	uc003bou.2	+	27	3707	c.3436G>T	c.(3436-3438)GGA>TGA	p.G1146*	CHL1_uc003bot.2_Nonsense_Mutation_p.G1162*|CHL1_uc011asi.1_Nonsense_Mutation_p.G1109*	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1146	Cytoplasmic (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GCCTCTCAAAGGAAGCCTTCG	0.398													7	31					2.7689e-08	3.7657e-08	1	0	T	447203	T	T	447203	4	4	212	1	0	0	0	0	0	1	0	0	3364	1001	35	4	3586	4	CHL1	3	447203	Nonsense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08		447203	197575227	15	38625											
SCN10A	6336	broad.mit.edu	37	chr3	38739945	38739945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtgcggatccccttggccGctcggatcagtctgaggatg	5	10	15	11	3	2	1	1	1	1	0	4	4	3	4	3	4	1	1	3	4	0	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr3:38739945G>A	uc003ciq.2	-	27	4766	c.4766C>T	c.(4765-4767)GCG>GTG	p.A1589V		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1589	IV.|Helical; Voltage-sensor; Name=S4 of repeat IV; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCCCTTGGCCGCTCGGATCAG	0.522													17	67					0	0	0	0	A	38739945	A	A	38739945	3	1	212	1	0	0	0	0	1	0	0	0	13977	1087	38	1	1108	1	SCN10A	3	38739945	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	38292742	38739945	159282485	16	38626											
AMIGO3	386724	broad.mit.edu	37	chr3	49755604	49755605	+	Frame_Shift_Del	DEL	TG	-	-																															tggtgctgagtactgaggacTgtgcgctcagctcttggagc																										TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr3:49755604_49755605delTG	uc003cxj.2	-	1	1634_1635	c.1294_1295delCA	c.(1294-1296)CAGfs	p.Q432fs	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	432	Cytoplasmic (Potential).				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TACTGAGGACTGTGCGCTCAGC	0.525													---	---	---								-	49755605	-	-	49755604	7	5	212	1	0	1	0	1	0	0	0	0	577	1580	55	0	223	0	AMIGO3	3	49755604	Frame_Shift_Del	DEL	TG	TCGA-CV-6959-01A-11D-1912-08	11015659	49755604	148266826	17	38627											
ROBO1	6091	broad.mit.edu	37	chr3	78711146	78711146	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atattgtaacaactcactgtCcagtgcacttcgatggaaga	13	11	8	9	1	1	1	1	0	0	1	3	3	2	2	1	1	3	2	1	1	4	4			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr3:78711146C>G	uc003dqe.2	-	15	2293	c.2085G>C	c.(2083-2085)TGG>TGC	p.W695C	ROBO1_uc003dqb.2_Missense_Mutation_p.W656C|ROBO1_uc003dqc.2_Missense_Mutation_p.W659C|ROBO1_uc003dqd.2_Missense_Mutation_p.W659C|ROBO1_uc010hoh.2_5'UTR|ROBO1_uc011bgl.1_Missense_Mutation_p.W267C|ROBO1_uc003dqf.1_Missense_Mutation_p.W374C	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	695	Extracellular (Potential).|Fibronectin type-III 2.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AACTCACTGTCCAGTGCACTT	0.453													4	10					0	0	0	0	G	78711146	G	G	78711146	3	3	212	1	0	0	0	0	1	0	0	0	13578	856	30	2	2938	2	ROBO1	3	78711146	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	28955542	78711146	119311284	18	38628											
RHO	6010	broad.mit.edu	37	chr3	129247885	129247885	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctctctgcatggatacttCgtcttcgggcccacaggatg	7	11	10	13	2	2	0	0	0	2	0	5	2	2	2	2	3	2	1	2	3	1	3	rs149615742	byFrequency	TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr3:129247885C>T	uc003emt.2	+	1	404	c.309C>T	c.(307-309)TTC>TTT	p.F103F		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	103	Extracellular.				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	ATGGATACTTCGTCTTCGGGC	0.602													21	148					0	0	0	0	T	129247885	T	T	129247885	2	4	212	1	0	0	0	0	0	0	0	1	13395	883	31	1		1	RHO	3	129247885	Silent	SNP	C	TCGA-CV-6959-01A-11D-1912-08	50536739	129247885	68774545	19	38629											
CFI	3426	broad.mit.edu	37	chr4	110667595	110667595	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tattcaattactatacgtttAaggtcggggtgtatccagtc	10	15	9	7	2	1	0	1	0	0	0	4	0	2	0	1	3	2	2	1	3	7	8			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr4:110667595A>G	uc003hzr.3	-	11	1420	c.1212T>C	c.(1210-1212)CTT>CTC	p.L404L	CFI_uc003hzq.2_Silent_p.L201L|CFI_uc011cft.1_Silent_p.L412L|CFI_uc003hzs.3_Silent_p.L397L	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	404	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		CTATACGTTTAAGGTCGGGGT	0.328													6	39					0	0	0	0	G	110667595	G	G	110667595	2	3	212	1	0	0	0	0	0	0	0	1	3304	349	13	5		5	CFI	4	110667595	Silent	SNP	A	TCGA-CV-6959-01A-11D-1912-08		110667595	80486681	20	38630											
CASP3	836	broad.mit.edu	37	chr4	185553070	185553070	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacacaaacaaaactgctcCttttgctgtgatcttcttta	11	14	5	11	0	2	1	0	1	2	0	3	1	3	1	1	0	4	3	1	0	4	5			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr4:185553070C>T	uc003iwh.2	-	6	595	c.332G>A	c.(331-333)AGG>AAG	p.R111K	CASP3_uc003iwg.2_Missense_Mutation_p.R111K|CASP3_uc003iwi.2_Missense_Mutation_p.R111K	NM_004346	NP_004337	P42574	CASP3_HUMAN	caspase 3 preproprotein	111					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|negative regulation of apoptosis|nerve growth factor receptor signaling pathway|nuclear fragmentation involved in apoptotic nuclear change|proteolysis|response to tumor necrosis factor	cytosol|mitochondrion|nucleoplasm|plasma membrane	cysteine-type endopeptidase activity|protein binding			kidney(1)	1		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.057)|all_hematologic(60;0.0592)		all cancers(43;2.05e-27)|Epithelial(43;4.27e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.04e-11)|Colorectal(24;2e-05)|STAD - Stomach adenocarcinoma(60;2.35e-05)|GBM - Glioblastoma multiforme(59;4.94e-05)|COAD - Colon adenocarcinoma(29;0.00017)|BRCA - Breast invasive adenocarcinoma(30;0.000218)|LUSC - Lung squamous cell carcinoma(40;0.00904)|READ - Rectum adenocarcinoma(43;0.161)	Melatonin(DB01065)|Minocycline(DB01017)|Simvastatin(DB00641)	AAAACTGCTCCTTTTGCTGTG	0.328													38	86					0	0	0	0	T	185553070	T	T	185553070	3	4	212	1	0	0	0	0	1	0	0	0	2684	681	24	4	513	4	CASP3	4	185553070	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	74885475	185553070	5601206	21	38631											
FAT1	2195	broad.mit.edu	37	chr4	187521088	187521088	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgcaaacgcctccattctGgcaagggttgctggcgcagt	8	10	12	11	2	1	0	0	0	1	0	2	0	2	0	2	3	3	5	2	3	2	3			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr4:187521088G>A	uc003izf.2	-	22	12255	c.12067C>T	c.(12067-12069)CAG>TAG	p.Q4023*	FAT1_uc003ize.2_5'Flank	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4023	Extracellular (Potential).|EGF-like 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CCTCCATTCTGGCAAGGGTTG	0.537										HNSCC(5;0.00058)			9	59					0	0	0	0	A	187521088	A	A	187521088	4	1	212	1	0	0	0	0	0	1	0	0	5721	1357	47	4	1723	4	FAT1	4	187521088	Nonsense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	1968018	187521088	3633188	22	38632											
RASA1	5921	broad.mit.edu	37	chr5	86659245	86659245	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttattttgaaagcgaaaaaCgagctaccaaaccaaaagga	19	8	7	7	2	0	1	0	1	0	0	0	4	0	2	2	1	5	1	2	1	8	5			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr5:86659245C>T	uc003kiw.2	+	11	1652	c.1534C>T	c.(1534-1536)CGA>TGA	p.R512*	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Nonsense_Mutation_p.R335*|RASA1_uc011ctv.1_Nonsense_Mutation_p.R345*|RASA1_uc011ctw.1_Nonsense_Mutation_p.R346*|RASA1_uc010jaw.2_Nonsense_Mutation_p.R334*	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	512	PH.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		AAGCGAAAAACGAGCTACCAA	0.328													18	31					0	0	0	0	T	86659245	T	T	86659245	4	4	212	1	0	0	0	0	0	1	0	0	13125	528	19	1	1588	1	RASA1	5	86659245	Nonsense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08		86659245	94256015	23	38633											
PCDHGB4	8641	broad.mit.edu	37	chr5	140768679	140768679	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacagatgctgttctagacCgcgagcagaatccagagtac	12	8	11	10	2	1	5	0	1	1	4	2	6	2	5	2	0	3	4	2	0	3	3			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr5:140768679C>T	uc003lkc.1	+	1	1228	c.1228C>T	c.(1228-1230)CGC>TGC	p.R410C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.R410C	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	410	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTCTAGACCGCGAGCAGAA	0.438													23	98					0	0	0	0	T	140768679	T	T	140768679	3	4	212	1	0	0	0	0	1	0	0	0	11619	652	23	1	1230	1	PCDHGB4	5	140768679	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	54109434	140768679	40146581	24	38634											
HIST1H3I	8354	broad.mit.edu	37	chr6	27839920	27839920	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttccggattagcagctcggtCgacttctggtagcggcggat	6	11	14	10	5	1	0	0	0	1	0	4	3	2	2	1	5	3	3	1	5	2	4			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr6:27839920C>T	uc003njy.2	-	1	180	c.174G>A	c.(172-174)TCG>TCA	p.S58S		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	58					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GCAGCTCGGTCGACTTCTGGT	0.652													21	134					0	0	0	0	T	27839920	T	T	27839920	2	4	212	1	0	0	0	0	0	0	0	1	7202	871	31	1		1	HIST1H3I	6	27839920	Silent	SNP	C	TCGA-CV-6959-01A-11D-1912-08		27839920	143275147	25	38635											
EHMT2	10919	broad.mit.edu	37	chr6	31847881	31847881	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcatgtgttgacagggggcaGggagccgagctcgggcagca	8	6	18	9	2	1	1	1	1	0	0	2	3	1	2	1	4	3	5	1	4	0	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr6:31847881G>A	uc003nxz.1	-	28	3623	c.3613C>T	c.(3613-3615)CTG>TTG	p.L1205L	EHMT2_uc003nxv.1_Silent_p.L244L|EHMT2_uc003nxw.1_Silent_p.L244L|EHMT2_uc003nxx.1_Silent_p.L403L|EHMT2_uc003nxy.1_Silent_p.L1003L|EHMT2_uc011don.1_Silent_p.L1228L|EHMT2_uc003nya.1_Silent_p.L1171L|SLC44A4_uc010jti.2_5'Flank|SLC44A4_uc011dol.1_5'Flank|SLC44A4_uc011dom.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1205					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						ACAGGGGGCAGGGAGCCGAGC	0.657													20	53					0	0	0	0	A	31847881	A	A	31847881	2	1	212	1	0	0	0	0	0	0	0	1	5006	991	35	4		4	EHMT2	6	31847881	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08	4007961	31847881	139267186	26	38636											
RIMS1	22999	broad.mit.edu	37	chr6	72968754	72968754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagacaccatgatgcctcccGaagtccagttgatcatagaa	13	8	8	12	1	1	4	1	2	0	2	3	5	3	4	4	0	1	1	4	0	3	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr6:72968754G>A	uc003pga.2	+	18	3070	c.2993G>A	c.(2992-2994)CGA>CAA	p.R998Q	RIMS1_uc011dyb.1_Missense_Mutation_p.R623Q|RIMS1_uc003pgc.2_Missense_Mutation_p.R624Q|RIMS1_uc010kaq.2_Missense_Mutation_p.R471Q|RIMS1_uc011dyc.1_Missense_Mutation_p.R472Q|RIMS1_uc010kar.2_Missense_Mutation_p.R391Q|RIMS1_uc011dyd.1_Missense_Mutation_p.R457Q|RIMS1_uc003pgf.2_Missense_Mutation_p.R214Q|RIMS1_uc003pgg.2_Missense_Mutation_p.R215Q|RIMS1_uc003pgi.2_Missense_Mutation_p.R214Q|RIMS1_uc003pgh.2_Missense_Mutation_p.R214Q|RIMS1_uc003pgd.2_Missense_Mutation_p.R215Q|RIMS1_uc003pge.2_Missense_Mutation_p.R215Q|RIMS1_uc011dye.1_5'UTR|RIMS1_uc011dyf.1_5'Flank|RIMS1_uc003pgb.3_Missense_Mutation_p.R624Q|RIMS1_uc010kas.1_Missense_Mutation_p.R457Q	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	998					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GATGCCTCCCGAAGTCCAGTT	0.353													13	85					0	0	0	0	A	72968754	A	A	72968754	3	1	212	1	0	0	0	0	1	0	0	0	13432	1058	37	1	3226	1	RIMS1	6	72968754	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	41120873	72968754	98146313	27	38637											
DOPEY1	23033	broad.mit.edu	37	chr6	83872585	83872585	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcagggtatacatcaacgaGaatttaaaccttacgtggta	14	10	10	7	2	1	1	1	0	0	1	1	2	1	1	1	3	4	3	1	3	8	6			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr6:83872585G>A	uc003pjs.1	+	38	7299	c.7039G>A	c.(7039-7041)GAA>AAA	p.E2347K	DOPEY1_uc011dyy.1_Missense_Mutation_p.E2338K|DOPEY1_uc010kbl.1_Missense_Mutation_p.E2338K|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	2347					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		ACATCAACGAGAATTTAAACC	0.393													38	84					0	0	0	0	A	83872585	A	A	83872585	3	1	212	1	0	0	0	0	1	0	0	0	4729	943	33	2	7181	2	DOPEY1	6	83872585	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	10903831	83872585	87242482	28	38638											
GRM1	2911	broad.mit.edu	37	chr6	146755794	146755794	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcgctgacgcctccgtcGcctttccgcgactcggtggc	2	9	12	18	7	0	1	0	1	0	0	4	2	2	1	5	2	1	1	5	2	0	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr6:146755794G>A	uc010khw.1	+	9	3917	c.3447G>A	c.(3445-3447)TCG>TCA	p.S1149S	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1149	Ser-rich.|Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CGCCTCCGTCGCCTTTCCGCG	0.652													21	77					0	0	0	0	A	146755794	A	A	146755794	2	1	212	1	0	0	0	0	0	0	0	1	6835	1074	38	1		1	GRM1	6	146755794	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08	62883209	146755794	24359273	29	38639											
NXPH1	30010	broad.mit.edu	37	chr7	8790658	8790658	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcacatgtgccaatttaacGaacggtggaaagtcagaact	14	9	10	8	2	2	1	2	0	0	1	2	3	2	2	1	2	4	0	1	2	5	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr7:8790658G>A	uc003srv.2	+	3	986	c.75G>A	c.(73-75)ACG>ACA	p.T25T	NXPH1_uc011jxh.1_5'UTR	NM_152745	NP_689958	P58417	NXPH1_HUMAN	neurexophilin 1 precursor	25	II.					extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		CCAATTTAACGAACGGTGGAA	0.423													32	69					0	0	0	0	A	8790658	A	A	8790658	2	1	212	1	0	0	0	0	0	0	0	1	10844	1045	37	1		1	NXPH1	7	8790658	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08		8790658	150348005	30	38640											
HECW1	23072	broad.mit.edu	37	chr7	43484716	43484716	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atggcgcggcccaggatggcGacacgcaccccagcaccggg	8	2	15	16	5	0	0	0	0	0	0	0	2	0	1	4	5	1	2	4	5	0	0			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr7:43484716G>A	uc003tid.1	+	11	2550	c.1945G>A	c.(1945-1947)GAC>AAC	p.D649N	HECW1_uc011kbi.1_Missense_Mutation_p.D649N	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	649					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CCAGGATGGCGACACGCACCC	0.721													9	17					0	0	0	0	A	43484716	A	A	43484716	3	1	212	1	0	0	0	0	1	0	0	0	7081	1058	37	1	1979	1	HECW1	7	43484716	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	34694058	43484716	115653947	31	38641											
LRRN3	54674	broad.mit.edu	37	chr7	110763263	110763263	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagcaacttacaagaactCtatattaatcacaacttgct	15	12	4	10	0	2	2	1	1	1	1	2	2	2	2	0	0	6	2	0	0	8	5			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr7:110763263C>A	uc003vft.3	+	4	1481	c.435C>A	c.(433-435)CTC>CTA	p.L145L	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Silent_p.L145L|LRRN3_uc003vfs.3_Silent_p.L145L	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	145	LRR 4.|Extracellular (Potential).					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		TACAAGAACTCTATATTAATC	0.373													5	49					0.00116845	0.00148977	1	0	A	110763263	A	A	110763263	2	1	212	1	0	0	0	0	0	0	0	1	9086	900	32	2		2	LRRN3	7	110763263	Silent	SNP	C	TCGA-CV-6959-01A-11D-1912-08	67278547	110763263	48375400	32	38642											
TNFRSF10B	8795	broad.mit.edu	37	chr8	22900702	22900702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcttttgttgtggggccgCtctctgctggggagctaggt	2	14	15	10	1	2	0	0	0	2	0	3	1	2	1	2	5	2	4	2	5	1	4			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr8:22900702C>T	uc003xcu.2	-	2	492	c.199G>A	c.(199-201)GCG>ACG	p.A67T	TNFRSF10B_uc003xct.2_Missense_Mutation_p.A67T|TNFRSF10B_uc011kzq.1_Intron|TNFRSF10B_uc003xcv.2_5'UTR	NM_003842	NP_003833	O14763	TR10B_HUMAN	tumor necrosis factor receptor superfamily,	67	Extracellular (Potential).|TNFR-Cys 1.				activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cell surface receptor linked signaling pathway|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|positive regulation of I-kappaB kinase/NF-kappaB cascade	plasma membrane	caspase activator activity|receptor activity|TRAIL binding				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0179)|COAD - Colon adenocarcinoma(73;0.0703)		TGTGGGGCCGCTCTCTGCTGG	0.572													5	38					0	0	0	0	T	22900702	T	T	22900702	3	4	212	1	0	0	0	0	1	0	0	0	16347	797	28	4	1155	4	TNFRSF10B	8	22900702	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08		22900702	123463320	33	38643											
XKR4	114786	broad.mit.edu	37	chr8	56015652	56015652	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcggcggtgggtctgcaGccggggaaggcgaggctcgt	4	7	21	9	5	1	0	0	0	1	0	3	2	1	1	1	8	2	2	1	8	1	0			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr8:56015652G>T	uc003xsf.2	+	1	636	c.604G>T	c.(604-606)GCC>TCC	p.A202S		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	202						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TGGGTCTGCAGCCGGGGAAGG	0.677													15	38					6.72482e-11	9.66101e-11	1	0	T	56015652	T	T	56015652	3	4	212	1	0	0	0	0	1	0	0	0	17501	971	34	4	606	4	XKR4	8	56015652	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	33114950	56015652	90348370	34	38644											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			11	9					0	0	0	0	A	21971120	A	A	21971120	4	1	212	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08		21971120	119242311	35	38645											
VPS13A	23230	broad.mit.edu	37	chr9	79938130	79938130	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagtaagaaggtcacaattcGctccccagtgcaggtatgaa	14	8	10	9	1	1	2	1	1	0	1	3	2	2	2	2	2	1	4	2	2	6	3			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr9:79938130G>T	uc004akr.2	+	45	6238	c.5978G>T	c.(5977-5979)CGC>CTC	p.R1993L	VPS13A_uc004akp.3_Missense_Mutation_p.R1993L|VPS13A_uc004akq.3_Missense_Mutation_p.R1993L|VPS13A_uc004aks.2_Missense_Mutation_p.R1954L|VPS13A_uc004akt.2_Missense_Mutation_p.R333L	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1993					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						GTCACAATTCGCTCCCCAGTG	0.383													17	33					3.41278e-10	4.76855e-10	1	0	T	79938130	T	T	79938130	3	4	212	1	0	0	0	0	1	0	0	0	17257	1087	38	3	6156	3	VPS13A	9	79938130	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	57967010	79938130	61275301	36	38646											
ACTL7B	10880	broad.mit.edu	37	chr9	111617576	111617576	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcaggcccggcagcacgtcgCcctcggatatgggcaccacg	7	5	13	16	5	1	0	1	0	0	0	3	1	1	1	3	4	1	3	3	4	1	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr9:111617576C>G	uc004bdi.2	-	1	700	c.635G>C	c.(634-636)GGC>GCC	p.G212A		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	212						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						CAGCACGTCGCCCTCGGATAT	0.662													6	38					0	0	0	0	G	111617576	G	G	111617576	3	3	212	1	0	0	0	0	1	0	0	0	201	739	26	4	616	4	ACTL7B	9	111617576	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	31679446	111617576	29595855	37	38647											
MEGF9	1955	broad.mit.edu	37	chr9	123476176	123476176	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacaggggtggtcggcgccGggccagtggtcgtcgaaagg	6	6	19	10	5	0	0	0	0	0	0	3	1	0	0	2	7	1	0	2	7	2	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr9:123476176G>T	uc004bkj.1	-	1	437	c.437C>A	c.(436-438)CCG>CAG	p.P146Q	MEGF9_uc011lyb.1_Missense_Mutation_p.P146Q|MEGF9_uc004bkk.3_Missense_Mutation_p.P146Q	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	154	Extracellular (Potential).|Pro-rich.					integral to membrane	calcium ion binding				0						GGTCGGCGCCGGGCCAGTGGT	0.741													6	47					2.74318e-10	3.88617e-10	1	0	T	123476176	T	T	123476176	3	4	212	1	0	0	0	0	1	0	0	0	9517	1116	39	3	1514	3	MEGF9	9	123476176	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	11858600	123476176	17737255	38	38648											
NOTCH1	4851	broad.mit.edu	37	chr9	139405210	139405210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggcaggatgcgccgtgccGgcacgggctcagaacgcact	7	5	15	14	5	1	1	1	0	0	1	1	2	1	2	2	4	3	4	2	4	1	0			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr9:139405210G>A	uc004chz.2	-	17	2635	c.2635C>T	c.(2635-2637)CGG>TGG	p.R879W	NOTCH1_uc004cia.1_Missense_Mutation_p.R109W	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	879	Extracellular (Potential).|EGF-like 23; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCGCCGTGCCGGCACGGGCTC	0.701			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			11	43					0	0	0	0	A	139405210	A	A	139405210	3	1	212	1	0	0	0	0	1	0	0	0	10601	1115	39	1	5104	1	NOTCH1	9	139405210	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	15929034	139405210	1808221	39	38649											
ZMYND11	10771	broad.mit.edu	37	chr10	294467	294467	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgccatgacaaatacaccaaGatcttcaatgacttcaaaga	17	9	5	10	0	3	4	2	2	1	2	3	4	3	4	2	0	2	0	2	0	5	3			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr10:294467G>C	uc010pzt.1	+	13	1847	c.1419G>C	c.(1417-1419)AAG>AAC	p.K473N	ZMYND11_uc001ifk.2_Missense_Mutation_p.K472N|ZMYND11_uc010pzu.1_Missense_Mutation_p.K473N|ZMYND11_uc010pzv.1_Missense_Mutation_p.K418N|ZMYND11_uc010pzw.1_Missense_Mutation_p.K388N|ZMYND11_uc001ifm.2_Missense_Mutation_p.K419N|ZMYND11_uc010pzx.1_Missense_Mutation_p.K473N|ZMYND11_uc001ifn.2_Missense_Mutation_p.K419N|ZMYND11_uc009xhg.2_Missense_Mutation_p.K456N|ZMYND11_uc009xhh.2_Missense_Mutation_p.K347N|ZMYND11_uc010pzy.1_Missense_Mutation_p.K325N	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	433	Interaction with human adenovirus E1A.				cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		AATACACCAAGATCTTCAATG	0.512													16	67					0	0	0	0	C	294467	C	C	294467	3	2	212	1	0	0	0	0	1	0	0	0	17773	933	33	2	1465	2	ZMYND11	10	294467	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08		294467	135240280	40	38650											
BEND7	222389	broad.mit.edu	37	chr10	13489310	13489310	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtctttcatcactgtccGcgatctctgctggttacaaa	8	13	7	13	2	4	0	2	0	2	0	6	1	5	0	2	1	2	2	2	1	2	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr10:13489310G>A	uc001imm.2	-	8	1334	c.1037C>T	c.(1036-1038)GCG>GTG	p.A346V	BEND7_uc001iml.2_RNA|BEND7_uc001imn.2_Missense_Mutation_p.A106V|BEND7_uc001imo.3_Missense_Mutation_p.A358V	NM_152751	NP_689964	Q8N7W2	BEND7_HUMAN	BEN domain containing 7 isoform 1	397							protein binding			ovary(1)|breast(1)	2						ATCACTGTCCGCGATCTCTGC	0.388													13	63					0	0	0	0	A	13489310	A	A	13489310	3	1	212	1	0	0	0	0	1	0	0	0	1405	1087	38	1	389	1	BEND7	10	13489310	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	13194843	13489310	122045437	41	38651											
SLC18A3	6572	broad.mit.edu	37	chr10	50820226	50820226	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgacgcgctcccgttcCgagcgcgatgtgctgcttga	4	10	12	15	6	0	2	0	2	0	0	3	4	3	2	3	0	3	4	3	0	0	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr10:50820226C>T	uc001jhw.2	+	1	1880	c.1440C>T	c.(1438-1440)TCC>TCT	p.S480S	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	480	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GCTCCCGTTCCGAGCGCGATG	0.657													13	53					0	0	0	0	T	50820226	T	T	50820226	2	4	212	1	0	0	0	0	0	0	0	1	14492	639	23	1		1	SLC18A3	10	50820226	Silent	SNP	C	TCGA-CV-6959-01A-11D-1912-08	37330916	50820226	84714521	42	38652											
TET1	80312	broad.mit.edu	37	chr10	70451332	70451332	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaaaacctaaataagcccCaacatggttttgaactaaac	19	8	4	10	0	0	1	0	1	0	0	0	1	0	1	3	1	5	1	3	1	9	5			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr10:70451332C>A	uc001jok.3	+	12	6677	c.6172C>A	c.(6172-6174)CAA>AAA	p.Q2058K		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	2058					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						AAATAAGCCCCAACATGGTTT	0.453													14	56					7.93312e-07	1.06471e-06	1	0	A	70451332	A	A	70451332	3	1	212	1	0	0	0	0	1	0	0	0	15835	595	21	4	6214	4	TET1	10	70451332	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	19631106	70451332	65083415	43	38653											
SIRT3	23410	broad.mit.edu	37	chr11	224206	224206	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacaacgccggtgcagaccgGgcagcggggaaccctgtctg	8	4	15	14	4	1	1	0	0	1	1	1	2	1	2	3	4	4	2	3	4	2	0			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr11:224206G>A	uc001lok.3	-	5	875	c.841C>T	c.(841-843)CCG>TCG	p.P281S	SIRT3_uc001loj.3_Missense_Mutation_p.P139S|SIRT3_uc010qvm.1_Missense_Mutation_p.P217S|SIRT3_uc010qvn.1_Missense_Mutation_p.P200S|SIRT3_uc010qvo.1_Missense_Mutation_p.P281S|SIRT3_uc010qvp.1_Intron|SIRT3_uc010qvq.1_Missense_Mutation_p.P139S|SIRT3_uc009ybt.1_RNA	NM_012239	NP_036371	Q9NTG7	SIRT3_HUMAN	sirtuin 3 isoform a	281	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			urinary_tract(1)	1		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		GTGCAGACCGGGCAGCGGGGA	0.557													9	43					0	0	0	0	A	224206	A	A	224206	3	1	212	1	0	0	0	0	1	0	0	0	14404	1232	43	4	370	4	SIRT3	11	224206	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08		224206	134782310	44	38654											
NAV2	89797	broad.mit.edu	37	chr11	20119140	20119140	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caggaatacatcattcatgtCgacccagtgagtcagctagg	12	9	10	10	1	3	1	3	1	0	0	4	3	3	2	1	2	2	1	1	2	3	3			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr11:20119140C>G	uc001mpr.3	+	31	6400	c.6039C>G	c.(6037-6039)GTC>GTG	p.V2013V	NAV2_uc001mpp.2_Silent_p.V1946V|NAV2_uc009yhx.2_Silent_p.V1074V|NAV2_uc009yhz.2_Silent_p.V655V|NAV2_uc001mpu.2_Silent_p.V448V	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	2069						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						TCATTCATGTCGACCCAGTGA	0.448													11	65					0	0	0	0	G	20119140	G	G	20119140	2	3	212	1	0	0	0	0	0	0	0	1	10237	871	31	3		3	NAV2	11	20119140	Silent	SNP	C	TCGA-CV-6959-01A-11D-1912-08	19894934	20119140	114887376	45	38655											
LRP6	4040	broad.mit.edu	37	chr12	12303861	12303861	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtcatagtcaatggccCggacattccgaaggctgtgg	8	9	15	9	2	2	0	2	0	0	0	3	2	3	1	2	5	0	1	2	5	3	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr12:12303861C>T	uc001rah.3	-	13	3045	c.2903G>A	c.(2902-2904)CGG>CAG	p.R968Q	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.R968Q	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	968	Extracellular (Potential).|Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				GTCAATGGCCCGGACATTCCG	0.493													46	104					0	0	0	0	T	12303861	T	T	12303861	3	4	212	1	0	0	0	0	1	0	0	0	9012	652	23	1	1982	1	LRP6	12	12303861	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08		12303861	121548034	46	38656											
LRRK2	120892	broad.mit.edu	37	chr12	40716168	40716168	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	accacattgattctctcatgGaagaatggtttcctgggttg	9	14	10	8	0	2	2	1	1	1	1	4	3	3	3	2	3	0	2	2	3	2	4			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr12:40716168G>C	uc001rmg.3	+	37	5486	c.5365G>C	c.(5365-5367)GAA>CAA	p.E1789Q	LRRK2_uc009zjw.2_Missense_Mutation_p.E627Q|LRRK2_uc001rmi.2_Missense_Mutation_p.E622Q	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1789					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTCTCTCATGGAAGAATGGTT	0.403													30	171					0	0	0	0	C	40716168	C	C	40716168	3	2	212	1	0	0	0	0	1	0	0	0	9083	1175	41	2	5511	2	LRRK2	12	40716168	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	28412307	40716168	93135727	47	38657											
KRT83	3889	broad.mit.edu	37	chr12	52714887	52714887	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggtgatgcatggggggctgGgtccgcacacgcccccggag	5	6	18	12	3	0	1	0	1	0	0	1	2	1	2	3	6	1	3	3	6	0	0			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr12:52714887G>T	uc001saf.2	-	1	296	c.233C>A	c.(232-234)CCC>CAC	p.P78H		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	78	Head.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGGGGGGCTGGGTCCGCACAC	0.701													48	116					4.64027e-19	7.17132e-19	1	0	T	52714887	T	T	52714887	3	4	212	1	0	0	0	0	1	0	0	0	8536	1232	43	4	1284	4	KRT83	12	52714887	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	11998719	52714887	81137008	48	38658											
HPD	3242	broad.mit.edu	37	chr12	122294232	122294232	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acccaggtgctttcttacctGcacgatgtagtcacaatctt	9	13	7	12	1	3	0	1	0	2	0	3	1	3	0	2	1	3	3	2	1	3	4			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr12:122294232G>T	uc001ubj.2	-	6	362	c.322C>A	c.(322-324)CAG>AAG	p.Q108K	HPD_uc001ubk.2_Missense_Mutation_p.Q69K	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	108					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	TTTCTTACCTGCACGATGTAG	0.582													21	54					3.5997e-14	5.39955e-14	1	0	T	122294232	T	T	122294232	3	4	212	1	0	0	0	0	1	0	0	0	7371	1328	46	4	895	4	HPD	12	122294232	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	69579345	122294232	11557663	49	38659											
CGNL1	84952	broad.mit.edu	37	chr15	57732649	57732649	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagacagctaagcagattctCtacaattacctcaaagaagg	16	8	8	9	0	2	3	1	0	1	3	3	4	2	3	1	1	4	2	1	1	6	4			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr15:57732649C>T	uc002aeg.2	+	3	1753	c.1677C>T	c.(1675-1677)CTC>CTT	p.L559L	CGNL1_uc010bfw.2_Silent_p.L559L	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	559						myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGCAGATTCTCTACAATTACC	0.443													5	4					0	0	0	0	T	57732649	T	T	57732649	2	4	212	1	0	0	0	0	0	0	0	1	3319	900	32	2		2	CGNL1	15	57732649	Silent	SNP	C	TCGA-CV-6959-01A-11D-1912-08		57732649	44798743	50	38660											
HCN4	10021	broad.mit.edu	37	chr15	73635796	73635796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaagaggctgaggatcttcGtgaagcggacaatgcgcagg	11	7	16	7	3	1	3	0	2	1	1	2	5	1	5	0	4	2	3	0	4	3	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr15:73635796G>A	uc002avp.2	-	2	2133	c.1139C>T	c.(1138-1140)ACG>ATG	p.T380M		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	380	Helical; Voltage-sensor; Name=Segment S4; (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		GAGGATCTTCGTGAAGCGGAC	0.552													7	41					0	0	0	0	A	73635796	A	A	73635796	3	1	212	1	0	0	0	0	1	0	0	0	7038	1145	40	1	2500	1	HCN4	15	73635796	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	15903147	73635796	28895596	51	38661											
ADAMTS18	170692	broad.mit.edu	37	chr16	77465453	77465453	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccgttgtgcaaaatgtcGtgtgaaatatatgacccggc	10	11	11	9	3	0	2	0	2	0	0	1	2	0	2	2	1	2	2	2	1	5	3			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr16:77465453G>A	uc002ffc.3	-	3	653	c.234C>T	c.(232-234)CAC>CAT	p.H78H	ADAMTS18_uc002ffe.1_Translation_Start_Site|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	78					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GCAAAATGTCGTGTGAAATAT	0.488													52	274					0	0	0	0	A	77465453	A	A	77465453	2	1	212	1	0	0	0	0	0	0	0	1	263	1136	40	1		1	ADAMTS18	16	77465453	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08		77465453	12889300	52	38662											
AIPL1	23746	broad.mit.edu	37	chr17	6330371	6330371	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctggtaatcactcggggCatcaacctggccccagagct	8	8	10	15	1	3	1	2	0	1	1	4	1	3	1	4	4	2	3	4	4	2	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr17:6330371C>T	uc002gcp.2	-	4	567	c.472G>A	c.(472-474)GCC>ACC	p.A158T	AIPL1_uc002gcq.2_Missense_Mutation_p.A98T|AIPL1_uc002gcr.2_Missense_Mutation_p.A95T|AIPL1_uc010clk.2_Missense_Mutation_p.A136T|AIPL1_uc010cll.2_Missense_Mutation_p.A158T|AIPL1_uc002gcs.2_Missense_Mutation_p.A158T	NM_014336	NP_055151	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting	158					protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding				0				COAD - Colon adenocarcinoma(228;0.141)		TCACTCGGGGCATCAACCTGG	0.602													21	82					0	0	0	0	T	6330371	T	T	6330371	3	4	212	1	0	0	0	0	1	0	0	0	436	710	25	4	694	4	AIPL1	17	6330371	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08		6330371	74864839	53	38663											
POLR2A	5430	broad.mit.edu	37	chr17	7414779	7414779	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agaagatcatcatcacggagGatggggaattcaaggccctg	13	7	13	8	1	4	2	4	0	0	2	4	5	4	5	1	5	0	0	1	5	3	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr17:7414779G>C	uc002ghf.3	+	24	4207	c.3973G>C	c.(3973-3975)GAT>CAT	p.D1325H		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1325					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding	p.I1322_W1334del(1)		pancreas(1)	1		Prostate(122;0.173)				CATCACGGAGGATGGGGAATT	0.582													4	34					0	0	0	0	C	7414779	C	C	7414779	3	2	212	1	0	0	0	0	1	0	0	0	12269	1174	41	2	4067	2	POLR2A	17	7414779	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	1084408	7414779	73780431	54	38664											
TP53	7157	broad.mit.edu	37	chr17	7579390	7579393	+	Frame_Shift_Del	DEL	GGAA	-	-																															ctgccctggtaggttttctgGgaagggacagaagatgacag																										TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr17:7579390_7579393delGGAA	uc002gim.2	-	4	488_491	c.294_297delTTCC	c.(292-297)CCTTCCfs	p.P98fs	TP53_uc002gig.1_Frame_Shift_Del_p.P98fs|TP53_uc002gih.2_Frame_Shift_Del_p.P98fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.P98fs|TP53_uc010cni.1_Frame_Shift_Del_p.P98fs|TP53_uc002gij.2_Frame_Shift_Del_p.P98fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.P59fs|TP53_uc010cnk.1_Frame_Shift_Del_p.P113fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	98_99	Interaction with WWOX.		S -> F (in sporadic cancers; somatic mutation).|S -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.P98S(4)|p.S99fs*48(3)|p.G59fs*23(3)|p.P98L(2)|p.S99F(2)|p.V73fs*9(1)|p.S99P(1)|p.W91fs*13(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.S99fs*24(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGTTTTCTGGGAAGGGACAGAAG	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7579393	-	-	7579390	7	5	212	1	0	1	0	1	0	0	0	0	16448	1219	43	0	1005	0	TP53	17	7579390	Frame_Shift_Del	DEL	GGAA	TCGA-CV-6959-01A-11D-1912-08	164611	7579390	73615820	55	38665											
MYO1D	4642	broad.mit.edu	37	chr17	31094740	31094741	+	Frame_Shift_Del	DEL	CT	-	-																															tttcatggcatcagcaacaaCtctgaattcggcagcatcat																										TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr17:31094740_31094741delCT	uc002hho.1	-	7	756_757	c.744_745delAG	c.(742-747)AGAGTTfs	p.R248fs	MYO1D_uc002hhp.1_Frame_Shift_Del_p.R248fs|MYO1D_uc010wcb.1_Frame_Shift_Del_p.R248fs	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	248_249	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			TCAGCAACAACTCTGAATTCGG	0.381													---	---	---								-	31094741	-	-	31094740	7	5	212	1	0	1	0	1	0	0	0	0	10124	565	20	0	2339	0	MYO1D	17	31094740	Frame_Shift_Del	DEL	CT	TCGA-CV-6959-01A-11D-1912-08	23515350	31094740	50100470	56	38666											
LHX1	3975	broad.mit.edu	37	chr17	35299527	35299527	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaaccggcgctccaaggagCggaggatgaagcagctgagc	12	3	16	10	3	0	3	0	2	0	1	1	6	1	6	2	4	5	3	2	4	3	0			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr17:35299527C>T	uc002hnh.1	+	4	1702	c.706C>T	c.(706-708)CGG>TGG	p.R236W		NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	236	Homeobox.				cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				CTCCAAGGAGCGGAGGATGAA	0.741													4	28					0	0	0	0	T	35299527	T	T	35299527	3	4	212	1	0	0	0	0	1	0	0	0	8811	759	27	1	720	1	LHX1	17	35299527	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	4204787	35299527	45895683	57	38667											
KIAA0802	23255	broad.mit.edu	37	chr18	8783718	8783718	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggcgggccccccagcacccGggaggccgagctgaagctgc	7	2	16	16	3	0	1	0	1	0	0	0	3	0	2	5	4	4	3	5	4	1	0			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr18:8783718G>C	uc002knr.2	+	6	750	c.608G>C	c.(607-609)CGG>CCG	p.R203P	KIAA0802_uc002knq.2_Missense_Mutation_p.R203P|KIAA0802_uc010dkw.1_Missense_Mutation_p.R41P	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	554	Potential.										0						CCCAGCACCCGGGAGGCCGAG	0.642													13	19					0	0	0	0	C	8783718	C	C	8783718	3	2	212	1	0	0	0	0	1	0	0	0	8233	1116	39	3	622	3	KIAA0802	18	8783718	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08		8783718	69293530	58	38668											
NOL4	8715	broad.mit.edu	37	chr18	31673461	31673461	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgaagattctggggacttTgcattctttcttcaagattg	9	16	9	7	0	4	3	1	1	3	2	4	4	4	4	0	2	1	1	0	2	2	6			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr18:31673461T>C	uc010dmi.2	-	5	969	c.740A>G	c.(739-741)CAA>CGA	p.Q247R	NOL4_uc002kxr.3_Missense_Mutation_p.Q83R|NOL4_uc010xbt.1_Missense_Mutation_p.Q173R|NOL4_uc010dmh.2_Missense_Mutation_p.Q173R|NOL4_uc010xbu.1_Missense_Mutation_p.Q247R|NOL4_uc002kxt.3_Missense_Mutation_p.Q247R|NOL4_uc010xbw.1_Missense_Mutation_p.Q133R	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	247						nucleolus	RNA binding			ovary(3)	3						CTGGGGACTTTGCATTCTTTC	0.383													12	79					0	0	0	0	C	31673461	C	C	31673461	3	2	212	1	0	0	0	0	1	0	0	0	10578	1812	63	5	1204	5	NOL4	18	31673461	Missense_Mutation	SNP	T	TCGA-CV-6959-01A-11D-1912-08	22889743	31673461	46403787	59	38669											
SERPINB8	5271	broad.mit.edu	37	chr18	61649018	61649018	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggagttgtcctttgctgaaGacactgaagagtgcaggaag	12	9	14	6	0	0	4	0	2	0	2	1	6	1	6	1	2	2	3	1	2	3	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr18:61649018G>C	uc002ljv.2	+	4	539	c.370G>C	c.(370-372)GAC>CAC	p.D124H	SERPINB8_uc002ljs.1_Missense_Mutation_p.D124H|SERPINB8_uc002ljt.2_Missense_Mutation_p.D124H|SERPINB8_uc002lju.2_Missense_Mutation_p.D124H|SERPINB8_uc010xex.1_5'UTR	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	124					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				CTTTGCTGAAGACACTGAAGA	0.413													42	71					0	0	0	0	C	61649018	C	C	61649018	3	2	212	1	0	0	0	0	1	0	0	0	14172	942	33	2	380	2	SERPINB8	18	61649018	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	29975557	61649018	16428230	60	38670											
RFX2	5990	broad.mit.edu	37	chr19	6040054	6040054	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtgctgtccatccccccgtgGatgagataggctcccgcgct	5	9	12	15	3	0	1	0	1	0	1	3	3	3	2	5	2	1	3	5	2	1	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr19:6040054G>T	uc002meb.2	-	5	728	c.459C>A	c.(457-459)ATC>ATA	p.I153I	RFX2_uc002mec.2_Silent_p.I153I|RFX2_uc010xiy.1_Silent_p.I108I	NM_000635	NP_000626	P48378	RFX2_HUMAN	regulatory factor X2 isoform a	153					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|ovary(1)|skin(1)	6						TCCCCCCGTGGATGAGATAGG	0.677													3	21					0.004672	0.00588326	1	0	T	6040054	T	T	6040054	2	4	212	1	0	0	0	0	0	0	0	1	13328	1164	41	2		2	RFX2	19	6040054	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08		6040054	53088929	61	38671											
MUC16	94025	broad.mit.edu	37	chr19	9061827	9061828	+	Frame_Shift_Del	DEL	AT	-	-																															catctccaggagttctactcAtaagagtggtcatctctgag																										TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr19:9061827_9061828delAT	uc002mkp.2	-	3	25822_25823	c.25618_25619delAT	c.(25618-25620)ATGfs	p.M8540fs		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8542	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTTCTACTCATAAGAGTGGTC	0.52													---	---	---								-	9061828	-	-	9061827	7	5	212	1	0	1	0	1	0	0	0	0	10026	217	8	0	18232	0	MUC16	19	9061827	Frame_Shift_Del	DEL	AT	TCGA-CV-6959-01A-11D-1912-08	3021773	9061827	50067156	62	38672											
ZNF560	147741	broad.mit.edu	37	chr19	9583928	9583928	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgacactgggtttaaagagCtgaaatcctttacatgaaga	15	11	9	6	0	0	5	0	3	0	2	1	5	1	5	1	1	2	2	1	1	5	4	rs138007443		TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr19:9583928C>A	uc002mlp.1	-	5	375	c.165G>T	c.(163-165)CAG>CAT	p.Q55H	ZNF560_uc010dwr.1_5'UTR	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	55	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						GTTTAAAGAGCTGAAATCCTT	0.299													29	149					4.22769e-11	6.16035e-11	1	0	A	9583928	A	A	9583928	3	1	212	1	0	0	0	0	1	0	0	0	18058	796	28	4	2231	4	ZNF560	19	9583928	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	522101	9583928	49545055	63	38673											
OR10H5	284433	broad.mit.edu	37	chr19	15905620	15905620	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtggtcgtgcactatggCtttgcctccgtcatttacct	4	15	11	11	2	1	0	1	0	0	0	3	0	2	0	3	3	3	2	3	3	2	4			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	dce738e5-e89f-49f0-aba7-710755af0c70	g.chr19:15905620C>A	uc010xos.1	+	1	762	c.762C>A	c.(760-762)GGC>GGA	p.G254G		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGCACTATGGCTTTGCCTCCG	0.572													8	46					0.00829132	0.00998727	1	0	A	15905620	A	A	15905620	2	1	212	1	0	0	0	0	0	0	0	1	10963	784	28	4		4	OR10H5	19	15905620	Silent	SNP	C	TCGA-CV-6959-01A-11D-1912-08	6321692	15905620	43223363	64	38674											
CPAMD8	27151	broad.mit.edu	37	chr19	17056415	17056415	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggggaccctcctgtcggCgtgattctcctcagggtgtt	4	12	14	11	2	2	1	1	1	1	0	5	3	3	2	3	4	0	1	3	4	0	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr19:17056415C>T	uc002nfb.2	-	22	2910	c.2878G>A	c.(2878-2880)GCC>ACC	p.A960T		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	913						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CTCCTGTCGGCGTGATTCTCC	0.567													19	92					0	0	0	0	T	17056415	T	T	17056415	3	4	212	1	0	0	0	0	1	0	0	0	3810	768	27	1	3004	1	CPAMD8	19	17056415	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	1150795	17056415	42072568	65	38675											
SBSN	374897	broad.mit.edu	37	chr19	36017775	36017775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgctttgtctgcttccttcCcggcctgttcaagggtatgg	3	14	11	13	2	2	0	1	0	1	0	4	0	4	0	4	3	1	4	4	3	2	5			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr19:36017775C>T	uc002oae.1	-	2	450	c.380G>A	c.(379-381)GGG>GAG	p.G127E	SBSN_uc002oad.1_Missense_Mutation_p.G470E	NM_198538	NP_940940	Q6UWP8	SBSN_HUMAN	suprabasin isoform 2 precursor	127	Ala/Gly/His-rich.					extracellular region				ovary(1)	1	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TGCTTCCTTCCCGGCCTGTTC	0.597													7	20					0	0	0	0	T	36017775	T	T	36017775	3	4	212	1	0	0	0	0	1	0	0	0	13929	623	22	4	379	4	SBSN	19	36017775	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	18961360	36017775	23111208	66	38676											
SIPA1L3	23094	broad.mit.edu	37	chr19	38655170	38655170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaacaccctctccagcaacGcatccagcagccacagcgac	12	3	7	19	2	1	0	0	0	1	0	3	1	2	0	4	0	6	4	4	0	2	0			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr19:38655170G>A	uc002ohk.2	+	15	4341	c.3832G>A	c.(3832-3834)GCA>ACA	p.A1278T		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1278					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CTCCAGCAACGCATCCAGCAG	0.617													26	56					0	0	0	0	A	38655170	A	A	38655170	3	1	212	1	0	0	0	0	1	0	0	0	14396	1087	38	1	3882	1	SIPA1L3	19	38655170	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08	2637395	38655170	20473813	67	38677											
PPFIA3	8541	broad.mit.edu	37	chr19	49640003	49640003	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgggagcggtctgcccctgCgggctccataccacccccat	5	8	11	17	2	1	0	0	0	1	0	2	1	2	1	6	3	4	1	6	3	1	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr19:49640003C>T	uc002pmr.2	+	15	2020	c.1688C>T	c.(1687-1689)GCG>GTG	p.A563V	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010emt.2_Missense_Mutation_p.A487V|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Missense_Mutation_p.A431V	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	563						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		TCTGCCCCTGCGGGCTCCATA	0.652													6	8					0	0	0	0	T	49640003	T	T	49640003	3	4	212	1	0	0	0	0	1	0	0	0	12366	768	27	1	1742	1	PPFIA3	19	49640003	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	10984833	49640003	9488980	68	38678											
BPIL1	80341	broad.mit.edu	37	chr20	31606143	31606143	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtcaccagtgactacatttCcctggaagtcaatgtaagtg	11	12	9	9	0	2	1	2	1	0	0	3	2	3	2	2	1	1	1	2	1	4	3			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr20:31606143C>A	uc002wyj.2	+	8	850	c.656C>A	c.(655-657)TCC>TAC	p.S219Y		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	219						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						GACTACATTTCCCTGGAAGTC	0.567													28	176					7.38237e-10	1.01757e-09	1	0	A	31606143	A	A	31606143	3	1	212	1	0	0	0	0	1	0	0	0	1496	855	30	2	682	2	BPIL1	20	31606143	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08		31606143	31419377	69	38679											
EIF2S2	8894	broad.mit.edu	37	chr20	32693175	32693175	+	Frame_Shift_Del	DEL	T	-	-																															tctcacatcaaccacgcaccTtttttcctagtgtcctcttc																										TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr20:32693175delT	uc002xaf.2	-	2	361	c.192delA	c.(190-192)AAAfs	p.K64fs	EIF2S2_uc002xag.2_Frame_Shift_Del_p.K64fs|EIF2S2_uc010ges.2_Frame_Shift_Del_p.K39fs	NM_003908	NP_003899	P20042	IF2B_HUMAN	eukaryotic translation initiation factor 2 beta	64						cytosol|eukaryotic translation initiation factor 2 complex	metal ion binding|protein binding|translation initiation factor activity			large_intestine(1)	1						ACCACGCACCTTTTTTCCTAG	0.483													---	---	---								-	32693175	-	-	32693175	7	5	212	1	0	1	0	1	0	0	0	0	5032	1623	56	0	841	0	EIF2S2	20	32693175	Frame_Shift_Del	DEL	T	TCGA-CV-6959-01A-11D-1912-08	1087032	32693175	30332345	70	38680											
FAM83C	128876	broad.mit.edu	37	chr20	33876323	33876323	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acgaacttctccagggcctgCcccgtgaagcggcggccagc	7	5	13	16	4	1	1	0	1	1	0	2	2	1	1	5	3	4	0	5	3	2	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr20:33876323C>T	uc010zux.1	-	3	865	c.747G>A	c.(745-747)GGG>GGA	p.G249G	FAM83C_uc002xcb.1_Silent_p.G73G	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	249										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCAGGGCCTGCCCCGTGAAGC	0.622													19	463					0	0	0	0	T	33876323	T	T	33876323	2	4	212	1	0	0	0	0	0	0	0	1	5667	726	26	4		4	FAM83C	20	33876323	Silent	SNP	C	TCGA-CV-6959-01A-11D-1912-08	1183148	33876323	29149197	71	38681											
SFI1	9814	broad.mit.edu	37	chr22	32003955	32003955	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggcgggaagctgtgtcagtGcagatgtattaccgacagca	10	9	14	8	2	1	1	1	0	0	1	1	3	1	2	1	2	4	4	1	2	3	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chr22:32003955G>C	uc003ale.2	+	22	2583	c.2190G>C	c.(2188-2190)GTG>GTC	p.V730V	SFI1_uc003alf.2_Silent_p.V699V|SFI1_uc003alg.2_Silent_p.V648V|SFI1_uc011alp.1_Silent_p.V636V|SFI1_uc011alq.1_Silent_p.V675V|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	730					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						CTGTGTCAGTGCAGATGTATT	0.592													7	47					0	0	0	0	C	32003955	C	C	32003955	2	2	212	1	0	0	0	0	0	0	0	1	14221	1306	46	4		4	SFI1	22	32003955	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08		32003955	19300611	72	38682											
FAM47A	158724	broad.mit.edu	37	chrX	34149633	34149633	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taggagactggatctccgacGagtgatgggaggccccgggc	8	6	17	10	3	1	2	0	1	1	1	2	7	1	4	3	5	0	0	3	5	1	1			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chrX:34149633G>A	uc004ddg.2	-	1	796	c.763C>T	c.(763-765)CGT>TGT	p.R255C		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	255										ovary(4)|central_nervous_system(1)	5						GATCTCCGACGAGTGATGGGA	0.622													8	17					0	0	0	0	A	34149633	A	A	34149633	3	1	212	1	0	0	0	0	1	0	0	0	5601	1058	37	1	1616	1	FAM47A	23	34149633	Missense_Mutation	SNP	G	TCGA-CV-6959-01A-11D-1912-08		34149633	121120927	73	38683											
FAM155B	27112	broad.mit.edu	37	chrX	68725656	68725656	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctttcccgtgccccggcCgagttcccctccgccaaaaa	6	8	7	20	4	0	0	0	0	0	0	4	1	4	0	9	1	1	1	9	1	2	2	rs142803076	byFrequency	TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chrX:68725656C>A	uc004dxk.2	+	1	579	c.531C>A	c.(529-531)GCC>GCA	p.A177A		NM_015686	NP_056501	O75949	F155B_HUMAN	transmembrane protein 28	177						integral to membrane				ovary(1)|breast(1)	2						GTGCCCCGGCCGAGTTCCCCT	0.577													19	40					0.006122	0.00761518	1	0	A	68725656	A	A	68725656	2	1	212	1	0	0	0	0	0	0	0	1	5494	639	23	3		3	FAM155B	23	68725656	Silent	SNP	C	TCGA-CV-6959-01A-11D-1912-08	34576023	68725656	86544904	74	38684											
PCDH19	57526	broad.mit.edu	37	chrX	99662705	99662705	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcgccagtgacagtgacCaggccactgtgcgggtcgat	10	6	14	11	3	0	2	0	2	0	0	1	3	0	2	3	2	2	0	3	2	1	0			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chrX:99662705C>A	uc010nmz.2	-	1	2567	c.891G>T	c.(889-891)CTG>CTT	p.L297L	PCDH19_uc004efw.3_Silent_p.L297L|PCDH19_uc004efx.3_Silent_p.L297L	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	297	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						TGACAGTGACCAGGCCACTGT	0.597													43	44					9.39024e-22	1.47354e-21	1	0	A	99662705	A	A	99662705	2	1	212	1	0	0	0	0	0	0	0	1	11568	581	21	4		4	PCDH19	23	99662705	Silent	SNP	C	TCGA-CV-6959-01A-11D-1912-08	30937049	99662705	55607855	75	38685											
ATP2B3	492	broad.mit.edu	37	chrX	152808591	152808591	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catcttcacgctgcttggagCtggcggagaggaggaagaga	10	7	16	8	2	2	2	1	0	1	2	2	7	2	5	0	5	2	3	0	5	1	2			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	7c304ced-63fd-4624-9b57-e4196f5b1e3a	g.chrX:152808591C>G	uc004fht.1	+	5	1007	c.881C>G	c.(880-882)GCT>GGT	p.A294G	ATP2B3_uc004fhs.1_Missense_Mutation_p.A294G	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	294	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGCTTGGAGCTGGCGGAGAG	0.572													26	49					0	0	0	0	G	152808591	G	G	152808591	3	3	212	1	0	0	0	0	1	0	0	0	1143	797	28	4	899	4	ATP2B3	23	152808591	Missense_Mutation	SNP	C	TCGA-CV-6959-01A-11D-1912-08	53145886	152808591	2461969	76	38686											
IDH3G	3421	broad.mit.edu	37	chrX	153059758	153059758	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccttcgcggcgctgccggcGacggtcgctaccttcagcgc	3	7	14	17	8	1	0	1	0	0	0	3	1	1	0	3	3	3	2	3	3	1	3			TCGA-CV-6959-01A-11D-1912-08	TCGA-CV-6959-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	ff4cc4f1-9897-4d04-a3f6-c28a9b928b7a	dce738e5-e89f-49f0-aba7-710755af0c70	g.chrX:153059758G>A	uc004fip.2	-	1	210	c.24C>T	c.(22-24)GTC>GTT	p.V8V	IDH3G_uc004fio.2_Intron|IDH3G_uc004fiq.2_Silent_p.V8V|IDH3G_uc010num.2_5'UTR|IDH3G_uc004fir.2_5'UTR|IDH3G_uc004fit.1_Silent_p.V8V|IDH3G_uc004fis.2_5'UTR|SSR4_uc004fiv.2_5'Flank|SSR4_uc004fiw.2_5'Flank	NM_004135	NP_004126	P51553	IDH3G_HUMAN	isocitrate dehydrogenase 3 (NAD+) gamma isoform	8					carbohydrate metabolic process|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleolus	ATP binding|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	CGCTGCCGGCGACGGTCGCTA	0.687													3	8					0	0	0	0	A	153059758	A	A	153059758	2	1	212	1	0	0	0	0	0	0	0	1	7537	1045	37	1		1	IDH3G	23	153059758	Silent	SNP	G	TCGA-CV-6959-01A-11D-1912-08	251167	153059758	2210802	77	38687											
CHD5	26038	broad.mit.edu	37	chr1	6172998	6172998	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttcggaactgtcccctctgCtgtggatcaagctcagctcc	6	11	10	14	1	3	0	2	0	1	0	6	2	5	2	3	2	4	4	3	2	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:6172998C>A	uc001amb.1	-	34	5073	c.4973G>T	c.(4972-4974)AGC>ATC	p.S1658I	CHD5_uc001alz.1_Missense_Mutation_p.S515I|CHD5_uc001ama.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1658					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GTCCCCTCTGCTGTGGATCAA	0.592													32	65					1.45844e-13	1.99402e-13	1	0	A	6172998	A	A	6172998	3	1	213	1	0	0	0	0	1	0	0	0	3343	797	28	4	923	4	CHD5	1	6172998	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08		6172998	243077623	1	38688											
PTCHD2	57540	broad.mit.edu	37	chr1	11562935	11562935	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtcacctacgtggccatgCtggccaagcagtctaccagg	8	8	12	13	1	2	0	1	0	1	0	2	0	2	0	4	4	4	2	4	4	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:11562935C>T	uc001ash.3	+	3	1435	c.1297C>T	c.(1297-1299)CTG>TTG	p.L433L	PTCHD2_uc001asi.1_Silent_p.L433L	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	433	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CGTGGCCATGCTGGCCAAGCA	0.522													3	54					0	0	0	0	T	11562935	T	T	11562935	2	4	213	1	0	0	0	0	0	0	0	1	12795	796	28	4		4	PTCHD2	1	11562935	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	5389937	11562935	237687686	2	38689											
C1orf64	149563	broad.mit.edu	37	chr1	16332707	16332707	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcttccttcccagtcagcCcgctctgcccccaggaggtt	5	9	9	18	1	2	0	1	0	1	0	4	1	4	1	5	2	3	3	5	2	0	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:16332707C>T	uc001axn.2	+	2	444	c.376C>T	c.(376-378)CCG>TCG	p.P126S		NM_178840	NP_849162	Q8NEQ6	CA064_HUMAN	hypothetical protein LOC149563	126										breast(2)	2		Colorectal(325;0.000435)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;2.08e-05)|BRCA - Breast invasive adenocarcinoma(304;9.19e-05)|Kidney(64;0.000165)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		CCCAGTCAGCCCGCTCTGCCC	0.647													20	35					0	0	0	0	T	16332707	T	T	16332707	3	4	213	1	0	0	0	0	1	0	0	0	2064	623	22	4	382	4	C1orf64	1	16332707	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	4769772	16332707	232917914	3	38690											
EPHA8	2046	broad.mit.edu	37	chr1	22927549	22927549	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgcgctcatccgcagcccTgagagtctcagggccaccgc	7	6	12	16	3	2	1	2	1	1	1	4	3	3	1	4	1	2	2	4	1	0	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:22927549T>C	uc001bfx.1	+	15	2822	c.2697T>C	c.(2695-2697)CCT>CCC	p.P899P		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	899	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCCGCAGCCCTGAGAGTCTCA	0.647													3	87					0	0	0	0	C	22927549	C	C	22927549	2	2	213	1	0	0	0	0	0	0	0	1	5197	1567	55	5		5	EPHA8	1	22927549	Silent	SNP	T	TCGA-CV-6960-01A-41D-2012-08	6594842	22927549	226323072	4	38691											
NCDN	23154	broad.mit.edu	37	chr1	36028893	36028893	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccccctcgcttctgtgcaaGtatttcctgcagcagtggga	6	11	11	13	1	1	0	0	0	1	0	3	1	2	1	3	1	3	5	3	1	2	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:36028893G>C	uc001bza.2	+	6	1603	c.1476G>C	c.(1474-1476)AAG>AAC	p.K492N	NCDN_uc001bzb.2_Missense_Mutation_p.K492N|NCDN_uc001bzc.2_Missense_Mutation_p.K475N	NM_001014839	NP_001014839	Q9UBB6	NCDN_HUMAN	neurochondrin isoform 1	492					neuron projection development	cytosol|dendrite|neuronal cell body				large_intestine(2)|pancreas(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTCTGTGCAAGTATTTCCTGC	0.622													31	81					0	0	0	0	C	36028893	C	C	36028893	3	2	213	1	0	0	0	0	1	0	0	0	10268	1020	36	4	1494	4	NCDN	1	36028893	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	13101344	36028893	213221728	5	38692											
KIAA0754	643314	broad.mit.edu	37	chr1	39879476	39879476	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctgcagtgcccaccccagCagaatctgcctcctttgcag	7	9	9	16	0	1	1	0	0	1	1	2	1	2	1	5	0	6	4	5	0	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:39879476C>G	uc009vvt.1	+	1	4301	c.3539C>G	c.(3538-3540)GCA>GGA	p.A1180G	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	1044	Ala-rich.										0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCCACCCCAGCAGAATCTGCC	0.662													16	38					0	0	0	0	G	39879476	G	G	39879476	3	3	213	1	0	0	0	0	1	0	0	0	8231	710	25	4	3541	4	KIAA0754	1	39879476	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	3850583	39879476	209371145	6	38693											
C8A	731	broad.mit.edu	37	chr1	57341807	57341807	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctctgatgaggacgactGtgaagatgtcagggccattg	9	10	15	7	1	2	4	1	3	1	1	2	6	2	5	1	3	0	1	1	3	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:57341807G>A	uc001cyo.2	+	4	521	c.389G>A	c.(388-390)TGT>TAT	p.C130Y		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	130	LDL-receptor class A.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GAGGACGACTGTGAAGATGTC	0.542													16	38					0	0	0	0	A	57341807	A	A	57341807	3	1	213	1	0	0	0	0	1	0	0	0	2427	1377	48	4	403	4	C8A	1	57341807	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	17462331	57341807	191908814	7	38694											
ST6GALNAC3	256435	broad.mit.edu	37	chr1	76779616	76779616	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aacctggtacaaagtggataCcattctcctacacatacagg	14	9	7	11	0	1	0	0	0	1	0	2	1	1	1	3	3	5	1	3	3	6	5			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:76779616C>A	uc001dhh.2	+	2	308	c.145C>A	c.(145-147)CCA>ACA	p.P49T	ST6GALNAC3_uc001dhg.3_Missense_Mutation_p.P49T|ST6GALNAC3_uc010orh.1_Intron	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	49	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						AAAGTGGATACCATTCTCCTA	0.453													32	62					2.08457e-15	2.95009e-15	1	0	A	76779616	A	A	76779616	3	1	213	1	0	0	0	0	1	0	0	0	15291	507	18	4	151	4	ST6GALNAC3	1	76779616	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	19437809	76779616	172471005	8	38695											
SYDE2	84144	broad.mit.edu	37	chr1	85647842	85647842	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcagaaggggcaccatcagtCctatattttctttctctaca	10	14	6	11	0	4	1	2	0	2	1	6	1	5	1	2	2	1	1	2	2	4	6			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:85647842C>T	uc009wcm.2	-	3	2532	c.2483G>A	c.(2482-2484)GGA>GAA	p.G828E	SYDE2_uc001dku.3_Missense_Mutation_p.G828E	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	828	Rho-GAP.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		CACCATCAGTCCTATATTTTC	0.348													3	16					0	0	0	0	T	85647842	T	T	85647842	3	4	213	1	0	0	0	0	1	0	0	0	15502	855	30	2	1121	2	SYDE2	1	85647842	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	8868226	85647842	163602779	9	38696											
COL11A1	1301	broad.mit.edu	37	chr1	103354187	103354187	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttctggccagcgggtccCtgttagaaagaagagagagg	10	8	14	9	1	1	4	0	0	1	4	2	5	2	4	3	3	1	1	3	3	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:103354187C>A	uc001dul.2	-	62	4873	c.4555_splice	c.e62-1	p.G1519_splice	COL11A1_uc001duk.2_Splice_Site_p.G715_splice|COL11A1_uc001dum.2_Splice_Site_p.G1531_splice|COL11A1_uc001dun.2_Splice_Site_p.G1480_splice|COL11A1_uc009weh.2_Splice_Site_p.G1403_splice	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGCGGGTCCCTGTTAGAAAG	0.423													14	41					1.3612e-06	1.55383e-06	1	0	A	103354187	A	A	103354187	5	1	213	1	0	0	0	0	0	0	1	0	3682	695	24	4	890	4	COL11A1	1	103354187	Splice_Site	SNP	C	TCGA-CV-6960-01A-41D-2012-08	17706345	103354187	145896434	10	38697											
COL11A1	1301	broad.mit.edu	37	chr1	103471395	103471395	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaatagatgtatcttaccCtgtgacctttgtcacctggc	9	13	9	10	0	2	2	1	1	1	1	2	3	2	3	3	2	1	1	3	2	4	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:103471395C>A	uc001dul.2	-	18	2162	c.1844G>T	c.(1843-1845)AGG>ATG	p.R615M	COL11A1_uc001duk.2_Translation_Start_Site|COL11A1_uc001dum.2_Missense_Mutation_p.R627M|COL11A1_uc001dun.2_Missense_Mutation_p.R576M|COL11A1_uc009weh.2_Missense_Mutation_p.R499M	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	615	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTATCTTACCCTGTGACCTTT	0.289													26	64					2.12542e-12	2.84172e-12	1	0	A	103471395	A	A	103471395	3	1	213	1	0	0	0	0	1	0	0	0	3682	695	24	4	3776	4	COL11A1	1	103471395	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	117208	103471395	145779226	11	38698											
TMEM79	84283	broad.mit.edu	37	chr1	156261302	156261302	+	Frame_Shift_Del	DEL	G	-	-																															atgttcgtggtggagccggaGcgcatgctcactgccaccga																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:156261302delG	uc010phi.1	+	4	1294	c.1098delG	c.(1096-1098)GAGfs	p.E366fs	TMEM79_uc001fod.2_Frame_Shift_Del_p.E207fs|TMEM79_uc009wrw.2_Frame_Shift_Del_p.E366fs|C1orf85_uc001fof.3_Intron|C1orf85_uc001fog.1_Intron	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	366						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					TGGAGCCGGAGCGCATGCTCA	0.672													---	---	---								-	156261302	-	-	156261302	7	5	213	1	0	1	0	1	0	0	0	0	16269	962	34	0	1108	0	TMEM79	1	156261302	Frame_Shift_Del	DEL	G	TCGA-CV-6960-01A-41D-2012-08	52789907	156261302	92989319	12	38699											
KCNT2	343450	broad.mit.edu	37	chr1	196295982	196295982	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttagtttatttttgaatccaTaggcttttgcatcctcatag	9	19	6	7	0	1	1	1	1	0	0	3	1	3	1	2	1	1	3	2	1	5	9			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:196295982T>C	uc001gtd.1	-	19	2201	c.2141A>G	c.(2140-2142)TAT>TGT	p.Y714C	KCNT2_uc009wyt.1_Intron|KCNT2_uc001gte.1_Missense_Mutation_p.Y664C|KCNT2_uc001gtf.1_Missense_Mutation_p.Y714C|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.Y714C|KCNT2_uc001gth.1_Missense_Mutation_p.Y235C	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	714	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TTTGAATCCATAGGCTTTTGC	0.318													22	55					0	0	0	0	C	196295982	C	C	196295982	3	2	213	1	0	0	0	0	1	0	0	0	8131	1406	49	5	1306	5	KCNT2	1	196295982	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	40034680	196295982	52954639	13	38700											
TGFB2	7042	broad.mit.edu	37	chr1	218614596	218614596	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaagcatctgcttctccttgCtgcgtgtcccaagatttaga	8	13	9	11	1	2	2	0	0	2	2	4	3	3	2	2	0	4	3	2	0	3	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:218614596C>A	uc001hlm.2	+	7	1790	c.1137C>A	c.(1135-1137)TGC>TGA	p.C379*	TGFB2_uc001hln.2_Nonsense_Mutation_p.C407*|TGFB2_uc010pue.1_RNA|TGFB2_uc001hlo.2_RNA	NM_003238	NP_003229	P61812	TGFB2_HUMAN	transforming growth factor, beta 2 isoform 2	379					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding				0				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		CTTCTCCTTGCTGCGTGTCCC	0.403													28	59					4.87955e-14	6.70939e-14	1	0	A	218614596	A	A	218614596	4	1	213	1	0	0	0	0	0	1	0	0	15884	805	28	4	1251	4	TGFB2	1	218614596	Nonsense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	22318614	218614596	30636025	14	38701											
RYR2	6262	broad.mit.edu	37	chr1	237838057	237838057	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaggacctggaactggacaCgccttctattgagaaacgat	13	9	10	9	2	1	1	0	1	1	1	1	6	1	4	2	3	2	0	2	3	4	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr1:237838057C>A	uc001hyl.1	+	60	8861	c.8741C>A	c.(8740-8742)ACG>AAG	p.T2914K	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2914	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.|4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAACTGGACACGCCTTCTATT	0.408													5	16					0.00116845	0.00123478	1	0	A	237838057	A	A	237838057	3	1	213	1	0	0	0	0	1	0	0	0	13834	536	19	3	8979	3	RYR2	1	237838057	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	19223461	237838057	11412564	15	38702											
RNASEH1	246243	broad.mit.edu	37	chr2	3598055	3598055	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatcagtgtagacgacgacGaagtctcctgtgggaaaagg	12	7	13	9	3	2	1	1	0	1	1	3	5	2	2	2	2	0	1	2	2	4	1	rs139176330		TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:3598055G>A	uc002qxt.2	-	4	507	c.417C>T	c.(415-417)TTC>TTT	p.F139F	RNASEH1_uc002qxs.2_Silent_p.F22F	NM_002936	NP_002927	O60930	RNH1_HUMAN	ribonuclease H1	139	RNase H.				RNA catabolic process	cytoplasm	magnesium ion binding|ribonuclease H activity|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0713)|Epithelial(75;0.167)|all cancers(51;0.22)		AGACGACGACGAAGTCTCCTG	0.493													4	123					0	0	0	0	A	3598055	A	A	3598055	2	1	213	1	0	0	0	0	0	0	0	1	13476	1049	37	1		1	RNASEH1	2	3598055	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08		3598055	239601318	16	38703											
VIT	5212	broad.mit.edu	37	chr2	37035846	37035846	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaacctcaccaaagagtttGagatttccgacacggacacg	13	7	8	13	3	1	2	1	1	0	2	2	5	2	3	4	1	1	1	4	1	2	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:37035846G>C	uc002rpl.2	+	15	1842	c.1621G>C	c.(1621-1623)GAG>CAG	p.E541Q	VIT_uc002rpm.2_Missense_Mutation_p.E519Q|VIT_uc010ezv.2_Missense_Mutation_p.E497Q|VIT_uc010ezw.2_Missense_Mutation_p.E498Q	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	526	VWFA 2.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				CAAAGAGTTTGAGATTTCCGA	0.582													26	52					0	0	0	0	C	37035846	C	C	37035846	3	2	213	1	0	0	0	0	1	0	0	0	17239	1291	45	2	1800	2	VIT	2	37035846	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	33437791	37035846	206163527	17	38704											
HEATR5B	54497	broad.mit.edu	37	chr2	37232867	37232867	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatgttcaatgggctcctCaggtctaggggaacaaagaa	14	8	11	8	0	3	1	2	0	1	1	4	2	4	2	1	4	2	2	1	4	6	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:37232867C>A	uc002rpp.1	-	30	4909	c.4813G>T	c.(4813-4815)GAG>TAG	p.E1605*	HEATR5B_uc010ezy.1_Nonsense_Mutation_p.E189*	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1605							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				ATGGGCTCCTCAGGTCTAGGG	0.408													15	30					0.000308642	0.000330493	1	0	A	37232867	A	A	37232867	4	1	213	1	0	0	0	0	0	1	0	0	7071	835	29	2	1430	2	HEATR5B	2	37232867	Nonsense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	197021	37232867	205966506	18	38705											
ZFP36L2	678	broad.mit.edu	37	chr2	43451842	43451842	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatgaggctgctgagctcCggaccgaaggcgaaggcgtt	8	7	17	9	4	0	3	0	3	0	0	1	6	1	4	2	4	2	4	2	4	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:43451842C>A	uc002rsv.3	-	2	1392	c.1101G>T	c.(1099-1101)CCG>CCT	p.P367P	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	367					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				TGCTGAGCTCCGGACCGAAGG	0.532													9	16					0.00621372	0.00642615	1	0	A	43451842	A	A	43451842	2	1	213	1	0	0	0	0	0	0	0	1	17714	639	23	3		3	ZFP36L2	2	43451842	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	6218975	43451842	199747531	19	38706											
EIF2AK3	9451	broad.mit.edu	37	chr2	88874652	88874652	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggacaaagttcaaaggaGtgcccctcatcattgccatc	13	8	9	11	0	3	0	3	0	0	0	4	3	3	2	3	2	2	1	3	2	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:88874652G>A	uc002stc.3	-	13	2551	c.2349C>T	c.(2347-2349)CAC>CAT	p.H783H		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	783	Cytoplasmic (Potential).|Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						GTTCAAAGGAGTGCCCCTCAT	0.453													109	204					0	0	0	0	A	88874652	A	A	88874652	2	1	213	1	0	0	0	0	0	0	0	1	5020	1020	36	4		4	EIF2AK3	2	88874652	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	45422810	88874652	154324721	20	38707											
CNGA3	1261	broad.mit.edu	37	chr2	99012576	99012576	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtacattctcatcatcatcCactggaatgcctgcatctac	10	13	5	13	0	4	0	3	0	2	0	6	1	5	1	2	1	4	2	2	1	3	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:99012576C>A	uc002syt.2	+	8	1360	c.943C>A	c.(943-945)CAC>AAC	p.H315N	CNGA3_uc002syu.2_Missense_Mutation_p.H297N|CNGA3_uc010fij.2_Missense_Mutation_p.H319N	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	315	Helical; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CATCATCATCCACTGGAATGC	0.478													89	88					7.2861e-57	1.14496e-56	1	0	A	99012576	A	A	99012576	3	1	213	1	0	0	0	0	1	0	0	0	3613	594	21	4	969	4	CNGA3	2	99012576	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	10137924	99012576	144186797	21	38708											
MAP4K4	9448	broad.mit.edu	37	chr2	102475479	102475479	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtatatcaggcgacagctaGaagaggagcagcggcacttg	13	6	14	8	2	1	2	1	0	0	2	1	4	1	3	0	3	3	4	0	3	4	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:102475479G>C	uc002tbg.2	+	14	1472	c.1417G>C	c.(1417-1419)GAA>CAA	p.E473Q	MAP4K4_uc002tbc.2_Missense_Mutation_p.E473Q|MAP4K4_uc002tbd.2_Missense_Mutation_p.E473Q|MAP4K4_uc002tbe.2_Missense_Mutation_p.E473Q|MAP4K4_uc002tbf.2_Missense_Mutation_p.E473Q|MAP4K4_uc010yvy.1_Missense_Mutation_p.E473Q|MAP4K4_uc002tbh.2_Missense_Mutation_p.E473Q|MAP4K4_uc002tbi.2_Missense_Mutation_p.E326Q|MAP4K4_uc010yvz.1_Missense_Mutation_p.E453Q|MAP4K4_uc002tbk.2_5'UTR|MAP4K4_uc002tbj.1_Missense_Mutation_p.E369Q	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	473					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GCGACAGCTAGAAGAGGAGCA	0.502													27	165					0	0	0	0	C	102475479	C	C	102475479	3	2	213	1	0	0	0	0	1	0	0	0	9315	943	33	2	1471	2	MAP4K4	2	102475479	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	3462903	102475479	140723894	22	38709											
IL1A	3552	broad.mit.edu	37	chr2	113535595	113535595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctggttggtcttcatcttggGcagtcacatacaattgagtt	8	15	10	8	0	4	1	2	1	2	0	4	1	4	1	0	3	1	3	0	3	2	6			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:113535595G>A	uc002tig.2	-	6	1544	c.584C>T	c.(583-585)GCC>GTC	p.A195V		NM_000575	NP_000566	P01583	IL1A_HUMAN	interleukin 1, alpha proprotein	195					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			lung(1)	1						TTCATCTTGGGCAGTCACATA	0.388													14	58					0	0	0	0	A	113535595	A	A	113535595	3	1	213	1	0	0	0	0	1	0	0	0	7689	1203	42	4	239	4	IL1A	2	113535595	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	11060116	113535595	129663778	23	38710											
ZRANB3	84083	broad.mit.edu	37	chr2	136107559	136107559	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaggattgtaatacctcttCaggccttcctaaagctggtg	10	13	9	9	0	2	0	1	0	1	0	3	1	3	1	3	3	2	2	3	3	5	7			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:136107559C>A	uc002tum.2	-	5	703	c.586G>T	c.(586-588)GAA>TAA	p.E196*	ZRANB3_uc002tuk.2_5'UTR|ZRANB3_uc002tul.2_Nonsense_Mutation_p.E196*|ZRANB3_uc002tun.1_Nonsense_Mutation_p.E136*	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	196	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		AATACCTCTTCAGGCCTTCCT	0.408													11	36					4.3838e-07	5.07598e-07	1	0	A	136107559	A	A	136107559	4	1	213	1	0	0	0	0	0	1	0	0	18291	835	29	2	2721	2	ZRANB3	2	136107559	Nonsense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	22571964	136107559	107091814	24	38711											
MBD5	55777	broad.mit.edu	37	chr2	149247953	149247953	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gttaatgggtgtgtgcctagCccttcagatgctaaaagcat	10	12	11	8	0	1	1	1	0	0	1	1	1	1	1	2	1	4	3	2	1	4	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:149247953C>A	uc002twm.3	+	12	5041	c.4053C>A	c.(4051-4053)AGC>AGA	p.S1351R	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Missense_Mutation_p.S1351R|MBD5_uc002two.2_Missense_Mutation_p.S609R|MBD5_uc002twp.2_Missense_Mutation_p.S401R	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1351						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GTGTGCCTAGCCCTTCAGATG	0.408													21	47					1.01871e-10	1.30438e-10	1	0	A	149247953	A	A	149247953	3	1	213	1	0	0	0	0	1	0	0	0	9400	738	26	4	4079	4	MBD5	2	149247953	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	13140394	149247953	93951420	25	38712											
SLC4A10	57282	broad.mit.edu	37	chr2	162751316	162751316	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagcattcgaatagagcctcCcaaaaatgttccttcccagg	13	9	7	12	1	0	1	0	0	0	1	4	2	3	1	4	1	2	2	4	1	5	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:162751316C>G	uc002ubx.3	+	11	1506	c.1322C>G	c.(1321-1323)CCC>CGC	p.P441R	SLC4A10_uc010fpa.1_Missense_Mutation_p.P453R|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.P411R|SLC4A10_uc010zcs.1_Missense_Mutation_p.P422R	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	441	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						ATAGAGCCTCCCAAAAATGTT	0.328													18	57					0	0	0	0	G	162751316	G	G	162751316	3	3	213	1	0	0	0	0	1	0	0	0	14715	623	22	4	1449	4	SLC4A10	2	162751316	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	13503363	162751316	80448057	26	38713											
G6PC2	57818	broad.mit.edu	37	chr2	169764237	169764237	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctgtggtccgtgcccatagCcaaaaagtggtgtgctaacc	9	9	12	11	1	0	0	0	0	0	0	1	0	1	0	4	2	4	2	4	2	4	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:169764237C>A	uc002uem.2	+	5	808	c.716C>A	c.(715-717)GCC>GAC	p.A239D	G6PC2_uc002uen.2_3'UTR|G6PC2_uc010fpv.2_Missense_Mutation_p.A123D	NM_021176	NP_066999	Q9NQR9	G6PC2_HUMAN	islet-specific glucose-6-phosphatase-related	239	Lumenal (Potential).				gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			pancreas(1)	1						GTGCCCATAGCCAAAAAGTGG	0.512													30	59					8.16721e-17	1.19064e-16	1	0	A	169764237	A	A	169764237	3	1	213	1	0	0	0	0	1	0	0	0	6178	739	26	4	734	4	G6PC2	2	169764237	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	7012921	169764237	73435136	27	38714											
LRP2	4036	broad.mit.edu	37	chr2	170129512	170129512	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacccaaaccatcattatCtgttctgtggctgaggacac	12	10	8	11	0	3	1	1	1	2	0	3	3	3	2	2	2	2	2	2	2	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:170129512C>A	uc002ues.2	-	15	2254	c.2041G>T	c.(2041-2043)GAT>TAT	p.D681Y	LRP2_uc010zdf.1_Missense_Mutation_p.D612Y	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	681	EGF-like 3.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCATCATTATCTGTTCTGTGG	0.463													48	116					8.00217e-19	1.18805e-18	1	0	A	170129512	A	A	170129512	3	1	213	1	0	0	0	0	1	0	0	0	9006	913	32	2	12186	2	LRP2	2	170129512	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	365275	170129512	73069861	28	38715											
MYO3B	140469	broad.mit.edu	37	chr2	171259494	171259494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atttcaatcagcatgtttttGctcttgagcaggtaatagtg	10	16	9	6	0	3	1	2	1	1	0	3	1	3	1	0	1	3	5	0	1	3	6			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:171259494G>A	uc002ufy.2	+	19	2409	c.2266G>A	c.(2266-2268)GCT>ACT	p.A756T	MYO3B_uc002ufv.2_Missense_Mutation_p.A743T|MYO3B_uc010fqb.1_Missense_Mutation_p.A743T|MYO3B_uc002ufz.2_Missense_Mutation_p.A756T|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	756	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GCATGTTTTTGCTCTTGAGCA	0.398													5	31					0	0	0	0	A	171259494	A	A	171259494	3	1	213	1	0	0	0	0	1	0	0	0	10130	1319	46	4	2340	4	MYO3B	2	171259494	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	1129982	171259494	71939879	29	38716											
ZNF385B	151126	broad.mit.edu	37	chr2	180409678	180409678	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcacaagagcaggaagggtaGtagtgtggcatgtactgcct	11	8	15	7	0	0	1	0	0	0	1	0	2	0	2	1	3	3	6	1	3	5	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:180409678G>A	uc002unn.3	-	4	876	c.272C>T	c.(271-273)ACT>ATT	p.T91I	ZNF385B_uc002unj.2_5'UTR|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_5'UTR|ZNF385B_uc002unm.2_Missense_Mutation_p.T15I	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	91						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			AGGAAGGGTAGTAGTGTGGCA	0.448													37	88					0	0	0	0	A	180409678	A	A	180409678	3	1	213	1	0	0	0	0	1	0	0	0	17944	1029	36	4	1171	4	ZNF385B	2	180409678	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	9150184	180409678	62789695	30	38717											
ITGA4	3676	broad.mit.edu	37	chr2	182395331	182395331	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagagtgcaatgcagaccttGaaaggcatagtccggttctt	12	10	11	8	1	1	3	0	1	1	2	2	3	2	3	2	2	2	4	2	2	4	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:182395331G>C	uc002unu.2	+	24	3382	c.2619G>C	c.(2617-2619)TTG>TTC	p.L873F	ITGA4_uc002unv.2_Missense_Mutation_p.L118F	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	873	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TGCAGACCTTGAAAGGCATAG	0.413													23	48					0	0	0	0	C	182395331	C	C	182395331	3	2	213	1	0	0	0	0	1	0	0	0	7917	1281	45	2	2713	2	ITGA4	2	182395331	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	1985653	182395331	60804042	31	38718											
COL3A1	1281	broad.mit.edu	37	chr2	189849935	189849935	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttattagcctactcgccctCctaatggtcaaggacctcaa	10	12	6	13	1	2	0	2	0	0	0	4	1	3	1	4	2	2	0	4	2	6	5			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:189849935C>A	uc002uqj.1	+	3	412	c.295C>A	c.(295-297)CCT>ACT	p.P99T		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	99					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TACTCGCCCTCCTAATGGTCA	0.343													22	36					6.32553e-13	8.55183e-13	1	0	A	189849935	A	A	189849935	3	1	213	1	0	0	0	0	1	0	0	0	3703	855	30	2	305	2	COL3A1	2	189849935	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	7454604	189849935	53349438	32	38719											
GTF3C3	9330	broad.mit.edu	37	chr2	197640813	197640813	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgaaaacaacagagtagaaCgatgaagcaataacttcagt	19	7	9	6	1	1	4	1	2	0	2	1	5	1	4	0	0	5	2	0	0	8	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:197640813C>G	uc002uts.2	-	12	1706	c.1616G>C	c.(1615-1617)CGT>CCT	p.R539P	GTF3C3_uc010zgu.1_Missense_Mutation_p.R510P	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	539						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						CAGAGTAGAACGATGAAGCAA	0.323													23	51					0	0	0	0	G	197640813	G	G	197640813	3	3	213	1	0	0	0	0	1	0	0	0	6913	536	19	3	1072	3	GTF3C3	2	197640813	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	7790878	197640813	45558560	33	38720											
ABI2	10152	broad.mit.edu	37	chr2	204255845	204255845	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagccccctagtccccctaTgtcagggaaagggacacttg	10	7	11	13	0	1	0	1	0	0	0	2	3	2	2	4	2	1	0	4	2	4	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:204255845T>A	uc002vaa.2	+	5	792	c.557T>A	c.(556-558)ATG>AAG	p.M186K	ABI2_uc010zig.1_RNA|ABI2_uc002uzz.2_Missense_Mutation_p.M180K|ABI2_uc010zih.1_Intron|ABI2_uc010zii.1_Missense_Mutation_p.M180K|ABI2_uc010zij.1_Missense_Mutation_p.M124K|ABI2_uc002vab.2_Missense_Mutation_p.M135K|ABI2_uc010zik.1_Missense_Mutation_p.M21K|ABI2_uc010zil.1_Missense_Mutation_p.M21K|ABI2_uc010zim.1_Missense_Mutation_p.M21K|ABI2_uc002vac.2_Missense_Mutation_p.M21K	NM_005759	NP_005750	Q9NYB9	ABI2_HUMAN	abl interactor 2	186	Pro-rich.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0						AGTCCCCCTATGTCAGGGAAA	0.388													5	22					0	0	0	0	A	204255845	A	A	204255845	3	1	213	1	0	0	0	0	1	0	0	0	89	1464	51	5	553	5	ABI2	2	204255845	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	6615032	204255845	38943528	34	38721											
ERBB4	2066	broad.mit.edu	37	chr2	212530075	212530075	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtttggatggcatgggTggcactcccgatctggatca	7	11	14	9	1	2	0	1	0	1	0	3	3	3	2	1	5	1	4	1	5	0	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:212530075T>A	uc002veg.1	-	15	1942	c.1844A>T	c.(1843-1845)CAC>CTC	p.H615L	ERBB4_uc002veh.1_Missense_Mutation_p.H615L|ERBB4_uc010zji.1_Missense_Mutation_p.H615L|ERBB4_uc010zjj.1_Missense_Mutation_p.H615L|ERBB4_uc010fut.1_Missense_Mutation_p.H615L	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	615	Extracellular (Potential).|Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATGGCATGGGTGGCACTCCCG	0.473										TSP Lung(8;0.080)			14	43					0	0	0	0	A	212530075	A	A	212530075	3	1	213	1	0	0	0	0	1	0	0	0	5233	1696	59	5	2138	5	ERBB4	2	212530075	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	8274230	212530075	30669298	35	38722											
SPAG16	79582	broad.mit.edu	37	chr2	214794821	214794821	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactcctgcggcaattttgTggcttcctcctcactggata	6	13	9	13	1	1	0	1	0	0	0	4	1	4	1	3	3	1	3	3	3	2	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:214794821T>C	uc002veq.2	+	12	1444	c.1352T>C	c.(1351-1353)GTG>GCG	p.V451A	SPAG16_uc010fuz.1_Missense_Mutation_p.V302A|SPAG16_uc002ver.2_Missense_Mutation_p.V397A|SPAG16_uc010zjk.1_Missense_Mutation_p.V357A	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	451	WD 3.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		GGCAATTTTGTGGCTTCCTCC	0.423													28	41					0	0	0	0	C	214794821	C	C	214794821	3	2	213	1	0	0	0	0	1	0	0	0	15044	1696	59	5	1414	5	SPAG16	2	214794821	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	2264746	214794821	28404552	36	38723											
CUL3	8452	broad.mit.edu	37	chr2	225368493	225368493	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttcttgcataaacctaaaaAggaccattgctttatccaat	14	14	4	9	0	1	0	0	0	1	0	2	1	2	1	3	1	3	2	3	1	7	7			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:225368493A>C	uc002vny.2	-	9	1637	c.1253T>G	c.(1252-1254)CTT>CGT	p.L418R	CUL3_uc010zls.1_Missense_Mutation_p.L352R|CUL3_uc010fwy.1_Missense_Mutation_p.L424R	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	418					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		AAACCTAAAAAGGACCATTGC	0.303													4	13					0	0	0	0	C	225368493	C	C	225368493	3	2	213	1	0	0	0	0	1	0	0	0	4073	72	3	5	1085	5	CUL3	2	225368493	Missense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	10573672	225368493	17830880	37	38724											
DOCK10	55619	broad.mit.edu	37	chr2	225717743	225717743	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtaaggccgacaatactttGttgaatcgtaaacaaattct	14	13	7	7	2	1	1	0	1	1	0	2	2	1	1	1	1	2	3	1	1	7	6			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:225717743G>T	uc010fwz.1	-	17	2224	c.1985C>A	c.(1984-1986)ACA>AAA	p.T662K	DOCK10_uc002vob.2_Missense_Mutation_p.T656K	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	662							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		ACAATACTTTGTTGAATCGTA	0.368													22	38					1.28384e-07	1.5082e-07	1	0	T	225717743	T	T	225717743	3	4	213	1	0	0	0	0	1	0	0	0	4707	1377	48	4	4735	4	DOCK10	2	225717743	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	349250	225717743	17481630	38	38725											
COL6A3	1293	broad.mit.edu	37	chr2	238249123	238249123	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaggatggcaacagcctcccGaagcgcatcaaaggctcctc	12	5	10	14	2	1	0	1	0	0	0	4	2	3	1	3	3	3	3	3	3	4	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:238249123G>A	uc002vwl.2	-	38	8721	c.8436C>T	c.(8434-8436)TTC>TTT	p.F2812F	COL6A3_uc002vwo.2_Silent_p.F2606F|COL6A3_uc010znj.1_Silent_p.F2205F|COL6A3_uc002vwj.2_Silent_p.F193F	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2812	VWFA 12.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACAGCCTCCCGAAGCGCATCA	0.547													20	35					0	0	0	0	A	238249123	A	A	238249123	2	1	213	1	0	0	0	0	0	0	0	1	3716	1049	37	1		1	COL6A3	2	238249123	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	12531380	238249123	4950250	39	38726											
COL6A3	1293	broad.mit.edu	37	chr2	238283189	238283189	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatggccacggcaaagtccGggatgaaggagatggtctgc	11	6	16	8	2	1	2	0	1	1	1	2	5	2	3	2	5	1	1	2	5	3	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr2:238283189G>T	uc002vwl.2	-	8	3830	c.3545C>A	c.(3544-3546)CCG>CAG	p.P1182Q	COL6A3_uc002vwo.2_Missense_Mutation_p.P976Q|COL6A3_uc010znj.1_Missense_Mutation_p.P575Q|COL6A3_uc002vwq.2_Missense_Mutation_p.P976Q|COL6A3_uc002vwr.2_Missense_Mutation_p.P775Q	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1182	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGCAAAGTCCGGGATGAAGGA	0.622													23	39					3.8784e-16	5.55369e-16	1	0	T	238283189	T	T	238283189	3	4	213	1	0	0	0	0	1	0	0	0	3716	1116	39	3	6183	3	COL6A3	2	238283189	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	34066	238283189	4916184	40	38727											
GADL1	339896	broad.mit.edu	37	chr3	30875411	30875411	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcatcttgtgtgggttccaGgccacagagtcagccctatt	8	11	11	11	0	2	1	1	0	1	1	3	1	3	1	3	2	2	2	3	2	1	4	rs139652704	byFrequency	TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr3:30875411G>T	uc003cep.2	-	11	1031	c.984C>A	c.(982-984)GCC>GCA	p.A328A	GADL1_uc003ceq.1_Silent_p.A328A	NM_207359	NP_997242	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	328					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	GTGGGTTCCAGGCCACAGAGT	0.448													15	19					3.52763e-06	3.95225e-06	1	0	T	30875411	T	T	30875411	2	4	213	1	0	0	0	0	0	0	0	1	6219	987	35	4		4	GADL1	3	30875411	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08		30875411	167147019	41	38728											
CCR2	729230	broad.mit.edu	37	chr3	46399710	46399710	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatcctgaaaaccctgcttcGgtgtcgaaacgagaagaaga	15	7	10	9	3	0	4	0	1	0	3	3	6	1	4	2	1	3	1	2	1	6	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr3:46399710G>T	uc003cpn.3	+	2	1177	c.692G>T	c.(691-693)CGG>CTG	p.R231L	CCR2_uc003cpm.3_Missense_Mutation_p.R231L	NM_001123041	NP_001116513	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2 isoform A	231	Cytoplasmic (Potential).				astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			lung(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		ACCCTGCTTCGGTGTCGAAAC	0.453													103	142					1.26289e-39	1.9591e-39	1	0	T	46399710	T	T	46399710	3	4	213	1	0	0	0	0	1	0	0	0	2956	1116	39	3	694	3	CCR2	3	46399710	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	15524299	46399710	151622720	42	38729											
RNF123	63891	broad.mit.edu	37	chr3	49738099	49738099	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcggctcactatcgccatcCtgaggcatgagaagtcccgc	8	8	11	14	3	1	2	1	2	0	1	4	3	3	2	3	2	1	2	3	2	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr3:49738099C>T	uc003cxh.2	+	15	1320	c.1234C>T	c.(1234-1236)CTG>TTG	p.L412L	RNF123_uc010hky.1_Silent_p.L74L|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	412						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		TATCGCCATCCTGAGGCATGA	0.607													25	38					0	0	0	0	T	49738099	T	T	49738099	2	4	213	1	0	0	0	0	0	0	0	1	13498	680	24	4		4	RNF123	3	49738099	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	3338389	49738099	148284331	43	38730											
ACOX2	8309	broad.mit.edu	37	chr3	58520802	58520802	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttgcctgctccaggtatccCccaatgacactcggtgcact	7	11	8	15	1	0	1	0	1	0	0	3	1	2	1	4	2	3	3	4	2	2	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr3:58520802C>T	uc003dkl.2	-	2	207	c.32G>A	c.(31-33)GGG>GAG	p.G11E		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	acyl-Coenzyme A oxidase 2	11					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		CCAGGTATCCCCCAATGACAC	0.572													61	106					0	0	0	0	T	58520802	T	T	58520802	3	4	213	1	0	0	0	0	1	0	0	0	159	623	22	4	2069	4	ACOX2	3	58520802	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	8782703	58520802	139501628	44	38731											
CNTN3	5067	broad.mit.edu	37	chr3	74350820	74350820	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtgacggtttgccaaccCacggagaaaggtgtccgagc	9	8	14	10	3	0	2	0	1	0	1	1	4	1	2	3	3	3	2	3	3	2	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr3:74350820C>A	uc003dpm.1	-	14	2003	c.1923G>T	c.(1921-1923)GTG>GTT	p.V641V		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	641	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TTTGCCAACCCACGGAGAAAG	0.448													25	19					4.26978e-12	5.64637e-12	1	0	A	74350820	A	A	74350820	2	1	213	1	0	0	0	0	0	0	0	1	3657	581	21	4		4	CNTN3	3	74350820	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	15830018	74350820	123671610	45	38732											
SI	6476	broad.mit.edu	37	chr3	164758778	164758778	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaaacacatgggctttataAaacagagtgtagaggaaggg	16	7	12	6	0	0	2	0	0	0	2	0	3	0	3	1	3	2	2	1	3	6	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr3:164758778A>G	uc003fei.2	-	18	2171	c.2109T>C	c.(2107-2109)TTT>TTC	p.F703F		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	703	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GGGCTTTATAAAACAGAGTGT	0.348										HNSCC(35;0.089)			27	74					0	0	0	0	G	164758778	G	G	164758778	2	3	213	1	0	0	0	0	0	0	0	1	14362	11	1	5		5	SI	3	164758778	Silent	SNP	A	TCGA-CV-6960-01A-41D-2012-08	90407958	164758778	33263652	46	38733											
SI	6476	broad.mit.edu	37	chr3	164781266	164781266	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattaaaaaaacaccgaatgActttccagatgtatcttcaa	17	11	4	9	1	2	2	1	1	1	1	3	3	3	2	2	0	1	1	2	0	7	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr3:164781266A>G	uc003fei.2	-	8	933	c.871T>C	c.(871-873)TCA>CCA	p.S291P		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	291	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACACCGAATGACTTTCCAGAT	0.259										HNSCC(35;0.089)			8	42					0	0	0	0	G	164781266	G	G	164781266	3	3	213	1	0	0	0	0	1	0	0	0	14362	275	10	5	4776	5	SI	3	164781266	Missense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	22488	164781266	33241164	47	38734											
PIK3CA	5290	broad.mit.edu	37	chr3	178951964	178951964	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcttttctcaatgatgcttGgctctggaatgccagaacta	10	14	8	9	0	3	2	1	1	3	1	4	3	3	3	1	2	3	2	1	2	4	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr3:178951964G>C	uc003fjk.2	+	21	3176	c.3019G>C	c.(3019-3021)GGC>CGC	p.G1007R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1007	PI3K/PI4K.		G -> R (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G1007R(6)|p.G1007D(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCTTGGCTCTGGAAT	0.378		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			19	43					0	0	0	0	C	178951964	C	C	178951964	3	2	213	1	0	0	0	0	1	0	0	0	11968	1348	47	4	3097	4	PIK3CA	3	178951964	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	14170698	178951964	19070466	48	38735											
CCDC39	339829	broad.mit.edu	37	chr3	180349272	180349272	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attacctttattacataataGgcctgtgttttctcctcttc	8	19	4	10	0	2	0	0	0	2	0	4	0	2	0	3	1	2	1	3	1	5	9			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr3:180349272G>T	uc010hxe.2	-	14	2098	c.1983C>A	c.(1981-1983)GCC>GCA	p.A661A	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	661					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTACATAATAGGCCTGTGTTT	0.328													11	40					1.58986e-06	1.79788e-06	1	0	T	180349272	T	T	180349272	2	4	213	1	0	0	0	0	0	0	0	1	2824	987	35	4		4	CCDC39	3	180349272	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	1397308	180349272	17673158	49	38736											
BOD1L	259282	broad.mit.edu	37	chr4	13602128	13602128	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctttctcttcacttctgctGgcagtgagttggctgtcatc	4	17	9	11	0	5	1	2	1	3	0	7	1	5	1	0	2	1	4	0	2	0	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:13602128G>T	uc003gmz.1	-	10	6513	c.6396C>A	c.(6394-6396)GCC>GCA	p.A2132A	BOD1L_uc010idr.1_Silent_p.A1469A	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2132							DNA binding			ovary(5)|breast(1)	6						CACTTCTGCTGGCAGTGAGTT	0.473													14	35					1.5842e-08	1.91688e-08	1	0	T	13602128	T	T	13602128	2	4	213	1	0	0	0	0	0	0	0	1	1486	1335	47	4		4	BOD1L	4	13602128	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08		13602128	177552148	50	38737											
ATP8A1	10396	broad.mit.edu	37	chr4	42588439	42588439	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actttcacactcaattctgcCagaaatcctcatcaaactgt	13	12	3	13	0	5	1	4	0	1	1	6	1	6	1	2	0	2	0	2	0	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:42588439C>A	uc003gwr.2	-	9	881	c.649G>T	c.(649-651)GGC>TGC	p.G217C	ATP8A1_uc003gws.2_Missense_Mutation_p.G217C|ATP8A1_uc011byz.1_Missense_Mutation_p.G217C	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	217	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	TCAATTCTGCCAGAAATCCTC	0.343													14	35					0.00316338	0.00329973	1	0	A	42588439	A	A	42588439	3	1	213	1	0	0	0	0	1	0	0	0	1194	594	21	4	2961	4	ATP8A1	4	42588439	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	28986311	42588439	148565837	51	38738											
LPHN3	23284	broad.mit.edu	37	chr4	62812713	62812713	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccagtatgaagttgggaaCggaagctttgtccacaaatc	12	10	11	8	1	0	1	0	1	0	0	2	3	1	3	2	2	3	3	2	2	5	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:62812713C>G	uc010ihh.2	+	13	2470	c.2297C>G	c.(2296-2298)ACG>AGG	p.T766R	LPHN3_uc003hcq.3_Missense_Mutation_p.T766R|LPHN3_uc003hct.2_Missense_Mutation_p.T159R	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	753	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AAGTTGGGAACGGAAGCTTTG	0.403													59	140					0	0	0	0	G	62812713	G	G	62812713	3	3	213	1	0	0	0	0	1	0	0	0	8967	536	19	3	2347	3	LPHN3	4	62812713	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	20224274	62812713	128341563	52	38739											
PROL1	58503	broad.mit.edu	37	chr4	71275449	71275449	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttttttcttgctatttaccTtcctatctctaaccctgagc	6	20	3	12	0	2	1	0	1	2	0	4	1	3	1	3	0	4	1	3	0	4	10			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:71275449T>G	uc003hfi.2	+	3	578	c.404T>G	c.(403-405)CTT>CGT	p.L135R		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	135	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				GCTATTTACCTTCCTATCTCT	0.433													40	68					0	0	0	0	G	71275449	G	G	71275449	3	3	213	1	0	0	0	0	1	0	0	0	12616	1609	56	5	410	5	PROL1	4	71275449	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	8462736	71275449	119878827	53	38740											
ADAMTS3	9508	broad.mit.edu	37	chr4	73175117	73175117	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagagacctcatcttaccaaGcttcctgggagttctggtaa	10	11	10	10	0	3	1	1	0	2	1	4	4	4	2	3	2	2	3	3	2	3	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:73175117G>A	uc003hgk.1	-	15	2213	c.2176C>T	c.(2176-2178)CTT>TTT	p.L726F	ADAMTS3_uc003hgl.2_Missense_Mutation_p.L67F	NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	726	Spacer.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ATCTTACCAAGCTTCCTGGGA	0.408													18	38					0	0	0	0	A	73175117	A	A	73175117	3	1	213	1	0	0	0	0	1	0	0	0	267	971	34	4	1473	4	ADAMTS3	4	73175117	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	1899668	73175117	117979159	54	38741											
FGF5	2250	broad.mit.edu	37	chr4	81188293	81188293	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccatctgcagatctacccGgatggcaaagtcaatggatc	11	10	9	11	1	3	1	1	0	2	1	5	3	4	3	2	3	2	2	2	3	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:81188293G>T	uc003hmd.2	+	1	552	c.315G>T	c.(313-315)CCG>CCT	p.P105P	FGF5_uc003hme.2_Silent_p.P105P	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	105					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						AGATCTACCCGGATGGCAAAG	0.582													29	58					3.73988e-18	5.51861e-18	1	0	T	81188293	T	T	81188293	2	4	213	1	0	0	0	0	0	0	0	1	5887	1103	39	3		3	FGF5	4	81188293	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	8013176	81188293	109965983	55	38742											
DNAJB14	79982	broad.mit.edu	37	chr4	100830007	100830007	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgcccgtgaggtcatactgTtttcgcttttctggattact	5	18	9	9	2	2	1	1	1	1	0	3	2	2	2	1	2	3	2	1	2	2	7			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:100830007T>C	uc003hvl.2	-	4	649	c.498A>G	c.(496-498)AAA>AAG	p.K166K	DNAJB14_uc003hvk.2_Silent_p.K81K|DNAJB14_uc010ili.2_Silent_p.K99K	NM_001031723	NP_001026893	Q8TBM8	DJB14_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 14	166	J.				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding				0				OV - Ovarian serous cystadenocarcinoma(123;4.59e-09)		GGTCATACTGTTTTCGCTTTT	0.348													21	40					0	0	0	0	C	100830007	C	C	100830007	2	2	213	1	0	0	0	0	0	0	0	1	4641	1722	60	5		5	DNAJB14	4	100830007	Silent	SNP	T	TCGA-CV-6960-01A-41D-2012-08	19641714	100830007	90324269	56	38743											
ANK2	287	broad.mit.edu	37	chr4	114290872	114290872	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agcacagagaggagagctctCcgcggaaaaccagcctcgta	13	4	12	12	3	1	2	0	0	1	2	3	5	1	3	3	2	4	3	3	2	3	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:114290872C>G	uc003ibe.3	+	43	11621	c.11521C>G	c.(11521-11523)CCG>GCG	p.P3841A	ANK2_uc003ibd.3_Missense_Mutation_p.P1747A|ANK2_uc003ibf.3_Missense_Mutation_p.P1756A|ANK2_uc011cgc.1_Missense_Mutation_p.P932A|ANK2_uc003ibg.3_Missense_Mutation_p.P740A|ANK2_uc003ibh.3_Missense_Mutation_p.P430A|ANK2_uc011cgd.1_Missense_Mutation_p.P1143A	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3808					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GGAGAGCTCTCCGCGGAAAAC	0.537													24	40					0	0	0	0	G	114290872	G	G	114290872	3	3	213	1	0	0	0	0	1	0	0	0	621	855	30	2	11756	2	ANK2	4	114290872	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	13460865	114290872	76863404	57	38744											
TRPC3	7222	broad.mit.edu	37	chr4	122800901	122800901	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttgctgcatcattcacatCtcagcatgctgggattcagt	8	13	10	10	0	4	0	4	0	1	0	5	1	4	1	0	2	4	5	0	2	0	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:122800901C>G	uc003ieg.2	-	12	2830	c.2756G>C	c.(2755-2757)AGA>ACA	p.R919T	TRPC3_uc010inr.2_Missense_Mutation_p.R791T|TRPC3_uc003ief.2_Missense_Mutation_p.R846T|TRPC3_uc011cgl.1_Missense_Mutation_p.R583T	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	834	Extracellular (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						TCATTCACATCTCAGCATGCT	0.363													14	35					0	0	0	0	G	122800901	G	G	122800901	3	3	213	1	0	0	0	0	1	0	0	0	16646	913	32	2	13	2	TRPC3	4	122800901	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	8510029	122800901	68353375	58	38745											
FAT4	79633	broad.mit.edu	37	chr4	126408505	126408505	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatatgttttacagattaaGaatggcaaagtatattttac	16	16	6	3	0	0	2	0	0	0	2	0	2	0	2	0	1	2	3	0	1	9	9			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:126408505G>T	uc003ifj.3	+	16	12822	c.12822G>T	c.(12820-12822)AAG>AAT	p.K4274N	FAT4_uc011cgp.1_Missense_Mutation_p.K2515N|FAT4_uc003ifi.1_Missense_Mutation_p.K1752N	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4274	Laminin G-like 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TACAGATTAAGAATGGCAAAG	0.318													7	17					0.00198382	0.00207829	1	0	T	126408505	T	T	126408505	3	4	213	1	0	0	0	0	1	0	0	0	5724	933	33	2	12884	2	FAT4	4	126408505	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	3607604	126408505	64745771	59	38746											
PCDH10	57575	broad.mit.edu	37	chr4	134073619	134073619	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gacctgctgtggccgccaagCccgggcgcgcaagaagaaac	10	3	14	14	4	0	2	0	0	0	2	0	3	0	2	4	2	3	2	4	2	4	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr4:134073619C>A	uc003iha.2	+	1	3150	c.2324C>A	c.(2323-2325)GCC>GAC	p.A775D	PCDH10_uc003igz.2_Missense_Mutation_p.A775D	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	775	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GGCCGCCAAGCCCGGGCGCGC	0.592													13	26					0.00010058	0.000109149	1	0	A	134073619	A	A	134073619	3	1	213	1	0	0	0	0	1	0	0	0	11561	739	26	4	2326	4	PCDH10	4	134073619	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	7665114	134073619	57080657	60	38747											
CTNND2	1501	broad.mit.edu	37	chr5	10992676	10992676	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttacctgagcggttgttGggagacacgcgcacagggga	8	8	15	10	3	1	2	0	1	1	1	1	4	1	3	1	4	2	3	1	4	1	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr5:10992676G>T	uc003jfa.1	-	19	3343	c.3198C>A	c.(3196-3198)CCC>CCA	p.P1066P	CTNND2_uc010itt.2_Silent_p.P975P|CTNND2_uc011cmy.1_Silent_p.P729P|CTNND2_uc011cmz.1_Silent_p.P633P|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.P658P	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1066					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						AGCGGTTGTTGGGAGACACGC	0.592													14	57					3.27435e-08	3.92274e-08	1	0	T	10992676	T	T	10992676	2	4	213	1	0	0	0	0	0	0	0	1	4037	1335	47	4		4	CTNND2	5	10992676	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08		10992676	169922584	61	38748											
CTNND2	1501	broad.mit.edu	37	chr5	11397162	11397162	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctggctgaagctctggcccGtagctcgggcttgtgtgcct	3	11	14	13	2	1	1	0	1	1	0	2	1	1	1	3	3	3	5	3	3	2	2	rs141302945		TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr5:11397162G>A	uc003jfa.1	-	6	738	c.593C>T	c.(592-594)ACG>ATG	p.T198M	CTNND2_uc010itt.2_Missense_Mutation_p.T107M|CTNND2_uc011cmy.1_Intron|CTNND2_uc011cmz.1_Translation_Start_Site|CTNND2_uc010itu.1_Intron	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	198					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GCTCTGGCCCGTAGCTCGGGC	0.607													41	106					0	0	0	0	A	11397162	A	A	11397162	3	1	213	1	0	0	0	0	1	0	0	0	4037	1145	40	1	3152	1	CTNND2	5	11397162	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	404486	11397162	169518098	62	38749											
NPR3	4883	broad.mit.edu	37	chr5	32783095	32783095	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgagaatagatgaaaacCgaattgtagagcatacaaac	20	7	8	6	1	0	4	0	2	0	3	0	6	0	4	1	0	5	2	1	0	9	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr5:32783095C>G	uc003jhv.2	+	6	1605	c.1387C>G	c.(1387-1389)CGA>GGA	p.R463G	NPR3_uc010iuo.2_Missense_Mutation_p.R247G|NPR3_uc011cnz.1_Missense_Mutation_p.R247G|NPR3_uc003jhu.2_Missense_Mutation_p.R463G	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	463	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	AGATGAAAACCGAATTGTAGA	0.383													6	19					0	0	0	0	G	32783095	G	G	32783095	3	3	213	1	0	0	0	0	1	0	0	0	10650	644	23	3	1409	3	NPR3	5	32783095	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	21385933	32783095	148132165	63	38750											
ADAMTS12	81792	broad.mit.edu	37	chr5	33614378	33614378	+	Frame_Shift_Del	DEL	C	-	-																															cactgcactctgtccagtggCcgtactgccagaagtacatc																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr5:33614378delC	uc003jia.1	-	16	2655	c.2492delG	c.(2491-2493)GGCfs	p.G831fs	ADAMTS12_uc010iuq.1_Frame_Shift_Del_p.G746fs	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	831	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGTCCAGTGGCCGTACTGCCA	0.502										HNSCC(64;0.19)			---	---	---								-	33614378	-	-	33614378	7	5	213	1	0	1	0	1	0	0	0	0	257	739	26	0	2328	0	ADAMTS12	5	33614378	Frame_Shift_Del	DEL	C	TCGA-CV-6960-01A-41D-2012-08	831283	33614378	147300882	64	38751											
RAI14	26064	broad.mit.edu	37	chr5	34823148	34823148	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgggcccatccctgggaaaaCctggtgaaacctctccccca	9	7	9	16	0	1	1	0	1	1	0	3	2	2	2	6	3	2	0	6	3	3	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr5:34823148C>T	uc003jir.2	+	15	1397	c.1201C>T	c.(1201-1203)CCT>TCT	p.P401S	RAI14_uc010iur.2_Missense_Mutation_p.P372S|RAI14_uc011coj.1_Missense_Mutation_p.P401S|RAI14_uc003jis.2_Missense_Mutation_p.P404S|RAI14_uc003jit.2_Missense_Mutation_p.P401S|RAI14_uc011cok.1_Missense_Mutation_p.P393S	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	401						cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					CCTGGGAAAACCTGGTGAAAC	0.453													25	53					0	0	0	0	T	34823148	T	T	34823148	3	4	213	1	0	0	0	0	1	0	0	0	13073	507	18	4	1320	4	RAI14	5	34823148	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	1208770	34823148	146092112	65	38752											
GRIA1	2890	broad.mit.edu	37	chr5	153056596	153056596	+	Nonsense_Mutation	SNP	G	T	T																															atggggtgaaggtgatggctGaggctttccagagcctgcgg																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr5:153056596G>T	uc003lva.3	+	7	1269	c.904G>T	c.(904-906)GAG>TAG	p.E302*	GRIA1_uc003luy.3_Nonsense_Mutation_p.E302*|GRIA1_uc003luz.3_Nonsense_Mutation_p.E207*|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Nonsense_Mutation_p.E222*|GRIA1_uc011dcx.1_Nonsense_Mutation_p.E233*|GRIA1_uc011dcy.1_Nonsense_Mutation_p.E312*|GRIA1_uc011dcz.1_Nonsense_Mutation_p.E312*|GRIA1_uc010jia.1_Nonsense_Mutation_p.E282*	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	302	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGTGATGGCTGAGGCTTTCCA	0.552													17	23					1.67942e-08	2.02198e-08	1	0	T	153056596	T	T	153056596	4	4	213	1	0	0	0	0	0	1	0	0	6806	1291	45	2	930	2	GRIA1	5	153056596	Nonsense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	118233448	153056596	27858664	66	38753	72	2									
GRIA1	2890	broad.mit.edu	37	chr5	153056599	153056599	+	Missense_Mutation	SNP	G	C	C																															gggtgaaggtgatggctgagGctttccagagcctgcggagg																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr5:153056599G>C	uc003lva.3	+	7	1272	c.907G>C	c.(907-909)GCT>CCT	p.A303P	GRIA1_uc003luy.3_Missense_Mutation_p.A303P|GRIA1_uc003luz.3_Missense_Mutation_p.A208P|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.A223P|GRIA1_uc011dcx.1_Missense_Mutation_p.A234P|GRIA1_uc011dcy.1_Missense_Mutation_p.A313P|GRIA1_uc011dcz.1_Missense_Mutation_p.A313P|GRIA1_uc010jia.1_Missense_Mutation_p.A283P	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	303	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GATGGCTGAGGCTTTCCAGAG	0.562													15	21					0	0	0	0	C	153056599	C	C	153056599	3	2	213	1	0	0	0	0	1	0	0	0	6806	1203	42	4	933	4	GRIA1	5	153056599	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	3	153056599	27858661	67	38754	72	2									
RARS	5917	broad.mit.edu	37	chr5	167921571	167921571	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaggttttattaatgtccaCttaagaaaggattttgtatc	12	18	7	4	0	0	1	0	0	0	1	2	2	1	2	1	2	0	2	1	2	6	8			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr5:167921571C>T	uc003lzx.2	+	5	536	c.495C>T	c.(493-495)CAC>CAT	p.H165H	RARS_uc011deo.1_5'UTR	NM_002887	NP_002878	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	165					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|skin(1)	3	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		TTAATGTCCACTTAAGAAAGG	0.358													8	28					0	0	0	0	T	167921571	T	T	167921571	2	4	213	1	0	0	0	0	0	0	0	1	13123	564	20	4		4	RARS	5	167921571	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	14864972	167921571	12993689	68	38755											
NSD1	64324	broad.mit.edu	37	chr5	176687055	176687055	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgacttttgcctggctgctGggtcaaagatccttgcatct	7	14	10	10	0	2	2	1	1	1	1	3	2	3	2	2	2	3	3	2	2	1	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr5:176687055G>T	uc003mfr.3	+	14	5170	c.5032G>T	c.(5032-5034)GGG>TGG	p.G1678W	NSD1_uc003mft.3_Missense_Mutation_p.G1409W|NSD1_uc003mfs.1_Missense_Mutation_p.G1575W|NSD1_uc011dfx.1_Missense_Mutation_p.G1326W	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1678					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CCTGGCTGCTGGGTCAAAGAT	0.488			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			13	30					1.49906e-05	1.65649e-05	1	0	T	176687055	T	T	176687055	3	4	213	1	0	0	0	0	1	0	0	0	10723	1348	47	4	5082	4	NSD1	5	176687055	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	8765484	176687055	4228205	69	38756											
GCNT2	2651	broad.mit.edu	37	chr6	10529410	10529410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctatgtaacagaaacactctCtgaagaagaggctgggttcc	13	9	10	9	0	1	4	0	1	1	3	3	4	2	4	1	2	2	3	1	2	5	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr6:10529410C>T	uc010joo.2	+	3	817	c.266C>T	c.(265-267)TCT>TTT	p.S89F	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Missense_Mutation_p.S88F|GCNT2_uc010jon.2_Missense_Mutation_p.S88F	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	89	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		GAAACACTCTCTGAAGAAGAG	0.428													31	43					0	0	0	0	T	10529410	T	T	10529410	3	4	213	1	0	0	0	0	1	0	0	0	6336	913	32	2	268	2	GCNT2	6	10529410	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08		10529410	160585657	70	38757											
PEX6	5190	broad.mit.edu	37	chr6	42936617	42936617	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccagagaccctcaccttcaGtaagtggagcccaaggtgac	11	7	10	13	0	2	2	2	1	0	1	3	4	3	3	4	2	1	1	4	2	2	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr6:42936617G>A	uc003otf.2	-	6	1567	c.1474C>T	c.(1474-1476)CTG>TTG	p.L492L	PEX6_uc010jya.2_RNA	NM_000287	NP_000278	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	492					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)	1			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			CTCACCTTCAGTAAGTGGAGC	0.587													29	15					0	0	0	0	A	42936617	A	A	42936617	2	1	213	1	0	0	0	0	0	0	0	1	11805	1020	36	4		4	PEX6	6	42936617	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	32407207	42936617	128178450	71	38758											
COL12A1	1303	broad.mit.edu	37	chr6	75825753	75825753	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acctggtgaggtgtagccatCcaaataaatgagaggacaac	15	7	11	8	0	0	2	0	2	0	1	1	4	1	3	3	3	2	1	3	3	5	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr6:75825753C>T	uc003phs.2	-	48	7706	c.7540G>A	c.(7540-7542)GAT>AAT	p.D2514N	COL12A1_uc003pht.2_Missense_Mutation_p.D1350N	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2514	Nonhelical region (NC3).				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GTGTAGCCATCCAAATAAATG	0.328													4	30					0	0	0	0	T	75825753	T	T	75825753	3	4	213	1	0	0	0	0	1	0	0	0	3684	855	30	2	1727	2	COL12A1	6	75825753	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	32889136	75825753	95289314	72	38759											
ARMC2	84071	broad.mit.edu	37	chr6	109215694	109215694	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caggggaagagacatgcgagGgcctcatcatgccccagtag	11	5	14	11	1	2	1	2	0	0	1	2	4	2	2	3	3	2	1	3	3	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr6:109215694G>T	uc003pss.3	+	6	870	c.696G>T	c.(694-696)AGG>AGT	p.R232S	ARMC2_uc011eao.1_Missense_Mutation_p.R67S	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	232							binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		GACATGCGAGGGCCTCATCAT	0.488													22	56					7.41877e-09	9.06739e-09	1	0	T	109215694	T	T	109215694	3	4	213	1	0	0	0	0	1	0	0	0	953	1223	43	4	714	4	ARMC2	6	109215694	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	33389941	109215694	61899373	73	38760											
RFPL4B	442247	broad.mit.edu	37	chr6	112671295	112671295	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaccacgatctgacaaaaGatcccaggctggcctgtgtc	10	8	9	14	1	1	2	0	1	1	1	4	3	3	2	4	2	0	1	4	2	2	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr6:112671295G>T	uc003pvx.1	+	3	697	c.385G>T	c.(385-387)GAT>TAT	p.D129Y		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	129	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		TCTGACAAAAGATCCCAGGCT	0.557													22	38					3.5997e-14	4.97787e-14	1	0	T	112671295	T	T	112671295	3	4	213	1	0	0	0	0	1	0	0	0	13321	942	33	2	387	2	RFPL4B	6	112671295	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	3455601	112671295	58443772	74	38761											
RFPL4B	442247	broad.mit.edu	37	chr6	112671407	112671407	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggcgtctgcaaggagcCggctgacagaaagagcaatg	11	5	15	10	2	1	3	0	1	1	2	1	4	1	4	2	3	3	3	2	3	3	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr6:112671407C>A	uc003pvx.1	+	3	809	c.497C>A	c.(496-498)CCG>CAG	p.P166Q		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	166	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		TGCAAGGAGCCGGCTGACAGA	0.547													30	67					7.01153e-11	9.02549e-11	1	0	A	112671407	A	A	112671407	3	1	213	1	0	0	0	0	1	0	0	0	13321	652	23	3	499	3	RFPL4B	6	112671407	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	112	112671407	58443660	75	38762											
LAMA2	3908	broad.mit.edu	37	chr6	129723502	129723502	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccaaactaaattgccacctAtgtctgaggagcttaatgat	13	12	7	9	0	1	2	0	2	1	0	2	3	2	3	3	1	3	1	3	1	5	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr6:129723502A>G	uc003qbn.2	+	39	5701	c.5596A>G	c.(5596-5598)ATG>GTG	p.M1866V	LAMA2_uc003qbo.2_Missense_Mutation_p.M1866V	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1866	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATTGCCACCTATGTCTGAGGA	0.423													13	21					0	0	0	0	G	129723502	G	G	129723502	3	3	213	1	0	0	0	0	1	0	0	0	8646	449	16	5	5750	5	LAMA2	6	129723502	Missense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	17052095	129723502	41391565	76	38763											
L3MBTL3	84456	broad.mit.edu	37	chr6	130378576	130378576	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctaaaggaaagaaagcGtggtgctgggcatcctacct	11	8	11	11	1	0	1	0	0	0	1	2	2	2	2	4	3	3	2	4	3	5	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr6:130378576G>T	uc003qbt.2	+	9	863	c.693G>T	c.(691-693)GCG>GCT	p.A231A	L3MBTL3_uc003qbu.2_Silent_p.A206A	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	231					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		GAAAGAAAGCGTGGTGCTGGG	0.522													7	17					1.26484e-09	1.5697e-09	1	0	T	130378576	T	T	130378576	2	4	213	1	0	0	0	0	0	0	0	1	8633	1132	40	3		3	L3MBTL3	6	130378576	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	655074	130378576	40736491	77	38764											
MAP3K5	4217	broad.mit.edu	37	chr6	136990474	136990474	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtccagctgccaggaggAggaccgcataattaattcct	10	9	12	10	1	0	0	0	0	0	0	2	3	2	3	4	4	2	2	4	4	2	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr6:136990474A>G	uc003qhc.2	-	8	1674	c.1313T>C	c.(1312-1314)CTC>CCC	p.L438P	MAP3K5_uc011edk.1_Missense_Mutation_p.L283P|MAP3K5_uc010kgw.1_Missense_Mutation_p.L438P	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	438					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TGCCAGGAGGAGGACCGCATA	0.388													3	96					0	0	0	0	G	136990474	G	G	136990474	3	3	213	1	0	0	0	0	1	0	0	0	9306	304	11	5	2903	5	MAP3K5	6	136990474	Missense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	6611898	136990474	34124593	78	38765											
GPER	2852	broad.mit.edu	37	chr7	1131629	1131629	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtgaacatcagcttccgcGagaagatgaccatccccgac	11	7	10	13	3	1	4	1	2	0	2	3	6	3	4	4	1	2	1	4	1	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:1131629G>A	uc010ksd.1	+	2	654	c.265G>A	c.(265-267)GAG>AAG	p.E89K	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPER_uc003sjz.1_Missense_Mutation_p.E89K|GPER_uc003ska.1_Missense_Mutation_p.E89K|GPER_uc003skb.2_Missense_Mutation_p.E89K	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	89	Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		CAGCTTCCGCGAGAAGATGAC	0.582													15	51					0	0	0	0	A	1131629	A	A	1131629	3	1	213	1	0	0	0	0	1	0	0	0	6645	1059	37	1	267	1	GPER	7	1131629	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08		1131629	158007034	79	38766											
NPVF	64111	broad.mit.edu	37	chr7	25266438	25266438	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctcacgaggctcacctccaTatttcttccagatctcagag	9	12	6	14	1	4	2	3	0	3	2	8	3	6	2	3	1	0	1	3	1	1	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:25266438T>C	uc003sxo.2	-	2	393	c.346A>G	c.(346-348)ATG>GTG	p.M116V		NM_022150	NP_071433	Q9HCQ7	RFRP_HUMAN	neuropeptide VF precursor	116					neuropeptide signaling pathway	extracellular region|membrane	G-protein coupled receptor activity			ovary(1)	1						CTCACCTCCATATTTCTTCCA	0.493													48	119					0	0	0	0	C	25266438	C	C	25266438	3	2	213	1	0	0	0	0	1	0	0	0	10659	1406	49	5	252	5	NPVF	7	25266438	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	24134809	25266438	133872225	80	38767											
PDE1C	5137	broad.mit.edu	37	chr7	32209516	32209516	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttggcttctccttgacattCcctgtgagcccatcgatgag	6	13	9	13	1	1	3	0	3	1	0	4	4	2	3	3	1	1	1	3	1	0	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:32209516C>A	uc003tco.1	-	3	783	c.189G>T	c.(187-189)GGG>GGT	p.G63G		NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	Error:Variant_position_missing_in_Q14123_after_alignment					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CCTTGACATTCCCTGTGAGCC	0.517													25	105					3.6726e-16	5.2903e-16	1	0	A	32209516	A	A	32209516	2	1	213	1	0	0	0	0	0	0	0	1	11689	870	30	2		2	PDE1C	7	32209516	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	6943078	32209516	126929147	81	38768											
AMPH	273	broad.mit.edu	37	chr7	38433765	38433765	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcctggggccccctcagctGctgacaccaaggttccaaca	8	7	9	17	0	1	1	1	1	0	0	3	1	3	1	5	3	3	3	5	3	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:38433765G>A	uc003tgu.2	-	18	1517	c.1448C>T	c.(1447-1449)GCA>GTA	p.A483V	AMPH_uc003tgv.2_Missense_Mutation_p.A441V|AMPH_uc003tgt.2_Missense_Mutation_p.A368V|AMPH_uc003tgw.1_Missense_Mutation_p.A506V|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	483					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CCCCTCAGCTGCTGACACCAA	0.587													55	66					0	0	0	0	A	38433765	A	A	38433765	3	1	213	1	0	0	0	0	1	0	0	0	588	1319	46	4	655	4	AMPH	7	38433765	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	6224249	38433765	120704898	82	38769											
IGFBP1	3484	broad.mit.edu	37	chr7	45928583	45928583	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtgcaggagtctgacgcctCcgctccccatgctgcaggta	6	8	12	15	3	1	1	0	1	1	0	3	2	3	2	4	2	3	5	4	2	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:45928583C>A	uc003tnp.2	+	1	625	c.332C>A	c.(331-333)TCC>TAC	p.S111Y	IGFBP1_uc003tno.3_Missense_Mutation_p.S111Y|IGFBP1_uc010kyn.2_Missense_Mutation_p.S111Y	NM_000596	NP_000587	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	111						extracellular space	insulin-like growth factor binding			lung(1)	1						TCTGACGCCTCCGCTCCCCAT	0.478													4	4					0.00909568	0.00936662	1	0	A	45928583	A	A	45928583	3	1	213	1	0	0	0	0	1	0	0	0	7617	855	30	2	334	2	IGFBP1	7	45928583	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	7494818	45928583	113210080	83	38770											
GTF2IRD1	9569	broad.mit.edu	37	chr7	74015431	74015431	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctcggaaggaaattccgtctCctcttcctcctcgtcttcct	5	14	6	16	3	3	0	0	0	3	0	10	2	7	2	5	2	0	0	5	2	2	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:74015431C>G	uc003uaq.2	+	26	3128	c.2735C>G	c.(2734-2736)TCC>TGC	p.S912C	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.S929C|GTF2IRD1_uc003uap.2_Missense_Mutation_p.S897C|GTF2IRD1_uc003uar.1_Missense_Mutation_p.S897C	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	912	Ser-rich.			Missing: Cytoplasmic localization.		nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						AATTCCGTctcctcttcctcc	0.438													23	27					0	0	0	0	G	74015431	G	G	74015431	3	3	213	1	0	0	0	0	1	0	0	0	6907	855	30	2	2833	2	GTF2IRD1	7	74015431	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	28086848	74015431	85123232	84	38771											
PON1	5444	broad.mit.edu	37	chr7	94946068	94946068	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agctaatgaaagccagtccaTtaggcagtatctccaagtct	13	10	8	10	0	2	1	0	1	2	0	4	1	3	1	3	1	2	3	3	1	5	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:94946068T>G	uc003uns.2	-	3	276	c.179A>C	c.(178-180)AAT>ACT	p.N60T	PON1_uc011kih.1_Missense_Mutation_p.N60T	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	60					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	AGCCAGTCCATTAGGCAGTAT	0.398													46	323					0	0	0	0	G	94946068	G	G	94946068	3	3	213	1	0	0	0	0	1	0	0	0	12303	1493	52	5	916	5	PON1	7	94946068	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	20930637	94946068	64192595	85	38772											
TECPR1	25851	broad.mit.edu	37	chr7	97872809	97872809	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagacacagcccacactgaCaggcggcccacaggctcctc	11	3	10	17	1	0	2	0	1	0	1	2	3	1	2	3	3	1	1	3	3	0	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:97872809C>A	uc003upg.2	-	6	832	c.627G>T	c.(625-627)CTG>CTT	p.L209L	TECPR1_uc003uph.1_Silent_p.L130L	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	209	TECPR 1.					integral to membrane	protein binding			pancreas(1)	1						CCCACACTGACAGGCGGCCCA	0.647													84	47					1.51188e-25	2.33041e-25	1	0	A	97872809	A	A	97872809	2	1	213	1	0	0	0	0	0	0	0	1	15809	465	17	4		4	TECPR1	7	97872809	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	2926741	97872809	61265854	86	38773											
MUC17	140453	broad.mit.edu	37	chr7	100685833	100685833	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgaccagctctgagggtagCaccctttcaacaccttctgt	8	11	9	13	0	3	2	1	2	2	0	3	2	3	2	3	1	3	3	3	1	2	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:100685833C>T	uc003uxp.1	+	3	11189	c.11136C>T	c.(11134-11136)AGC>AGT	p.S3712S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3712	Extracellular (Potential).|59.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGAGGGTAGCACCCTTTCAA	0.507													441	189					0	0	0	0	T	100685833	T	T	100685833	2	4	213	1	0	0	0	0	0	0	0	1	10027	709	25	4		4	MUC17	7	100685833	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	2813024	100685833	58452830	87	38774											
RELN	5649	broad.mit.edu	37	chr7	103216153	103216153	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccatcggaatctggtcttgCtgttgggaaaaacaacacac	12	10	9	10	1	2	0	0	0	2	0	4	2	3	2	1	3	3	2	1	3	4	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:103216153C>A	uc003vca.2	-	29	4306	c.4146_splice	c.e29-1	p.S1382_splice	RELN_uc010liz.2_Splice_Site_p.S1382_splice	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a						axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCTGGTCTTGCTGTTGGGAAA	0.403													16	165					5.01169e-05	5.48792e-05	1	0	A	103216153	A	A	103216153	5	1	213	1	0	0	0	0	0	0	1	0	13285	811	28	4	6385	4	RELN	7	103216153	Splice_Site	SNP	C	TCGA-CV-6960-01A-41D-2012-08	2530320	103216153	55922510	88	38775											
LAMB1	3912	broad.mit.edu	37	chr7	107580499	107580499	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggggctctgcgccaggatGtcttttatctcgctgacttt	4	14	12	11	3	3	1	0	1	3	0	4	2	3	2	1	3	1	2	1	3	1	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:107580499G>C	uc003vew.2	-	25	4031	c.3696C>G	c.(3694-3696)GAC>GAG	p.D1232E	LAMB1_uc003vev.2_Missense_Mutation_p.D1256E	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1232	Potential.|Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCGCCAGGATGTCTTTTATCT	0.498													36	37					0	0	0	0	C	107580499	C	C	107580499	3	2	213	1	0	0	0	0	1	0	0	0	8650	1368	48	4	1704	4	LAMB1	7	107580499	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	4364346	107580499	51558164	89	38776											
CADPS2	93664	broad.mit.edu	37	chr7	122028668	122028668	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcctctagcatatcactggCcattagtttaagtctttgct	8	15	8	10	0	3	0	1	0	2	0	3	0	3	0	2	2	2	3	2	2	4	6			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:122028668C>T	uc010lkp.2	-	22	3296	c.3133G>A	c.(3133-3135)GCC>ACC	p.A1045T	CADPS2_uc011knx.1_Missense_Mutation_p.A420T|CADPS2_uc003vkg.3_Missense_Mutation_p.A699T|CADPS2_uc010lkq.2_Missense_Mutation_p.A999T	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	1045	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						ATATCACTGGCCATTAGTTTA	0.408													6	7					0	0	0	0	T	122028668	T	T	122028668	3	4	213	1	0	0	0	0	1	0	0	0	2583	739	26	4	808	4	CADPS2	7	122028668	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	14448169	122028668	37109995	90	38777											
OR6V1	346517	broad.mit.edu	37	chr7	142750110	142750110	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acatagtgaccactgtgctgCggatcccctctgccagcagc	8	8	10	15	1	1	1	0	1	1	0	2	2	2	2	4	1	5	2	4	1	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr7:142750110C>A	uc011ksv.1	+	1	673	c.673C>A	c.(673-675)CGG>AGG	p.R225R		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					CACTGTGCTGCGGATCCCCTC	0.532													55	63					2.12129e-23	3.22862e-23	1	0	A	142750110	A	A	142750110	2	1	213	1	0	0	0	0	0	0	0	1	11265	759	27	3		3	OR6V1	7	142750110	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	20721442	142750110	16388553	91	38778											
CEBPD	1052	broad.mit.edu	37	chr8	48649939	48649939	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggcagctgcttgaagaactgCcggaggccggccaggtcccg	7	5	16	13	3	0	2	0	1	0	1	1	3	1	3	4	5	4	3	4	5	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr8:48649939C>A	uc003xqh.1	-	1	788	c.744G>T	c.(742-744)CGG>CGT	p.R248R	KIAA0146_uc003xqg.1_Intron	NM_005195	NP_005186	P49716	CEBPD_HUMAN	CCAAT/enhancer binding protein delta	248	Leucine-zipper.				transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(86;0.0782)|Lung NSC(58;0.00363)|all_epithelial(80;0.0042)|all_lung(54;0.00914)				TGAAGAACTGCCGGAGGCCGG	0.687													11	30					1.58986e-06	1.79788e-06	1	0	A	48649939	A	A	48649939	2	1	213	1	0	0	0	0	0	0	0	1	3216	726	26	4		4	CEBPD	8	48649939	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08		48649939	97714083	92	38779											
ARFGEF1	10565	broad.mit.edu	37	chr8	68184172	68184172	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatcgtagttcatgagacCtaaaatgtaaaaaagaaggc	17	9	10	5	1	1	2	1	1	0	2	2	4	1	3	1	2	0	3	1	2	7	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr8:68184172C>A	uc003xxo.1	-	10	1728	c.1338_splice	c.e10-1	p.K446_splice		NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine						exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TTCATGAGACCTAAAATGTAA	0.318													12	13					6.40141e-05	6.97811e-05	1	0	A	68184172	A	A	68184172	5	1	213	1	0	0	0	0	0	0	1	0	852	695	24	4	4332	4	ARFGEF1	8	68184172	Splice_Site	SNP	C	TCGA-CV-6960-01A-41D-2012-08	19534233	68184172	78179850	93	38780											
INTS8	55656	broad.mit.edu	37	chr8	95863869	95863869	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agacaaattttaattgaattAcatggtatgacttcagagcg	15	13	8	5	1	1	4	1	2	0	2	1	4	1	4	0	1	2	1	0	1	5	6			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr8:95863869A>G	uc003yhb.2	+	13	1722	c.1596A>G	c.(1594-1596)TTA>TTG	p.L532L	INTS8_uc003yha.1_Silent_p.L532L|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Silent_p.L359L	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	532					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TAATTGAATTACATGGTATGA	0.363													19	45					0	0	0	0	G	95863869	G	G	95863869	2	3	213	1	0	0	0	0	0	0	0	1	7823	388	14	5		5	INTS8	8	95863869	Silent	SNP	A	TCGA-CV-6960-01A-41D-2012-08	27679697	95863869	50500153	94	38781											
RIMS2	9699	broad.mit.edu	37	chr8	105026790	105026790	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcaagtactccagtcgcagGacgaaggggccgacagcttc	11	6	12	12	3	1	0	1	0	0	0	4	3	2	1	2	3	2	3	2	3	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr8:105026790G>T	uc003yls.2	+	17	2742	c.2501G>T	c.(2500-2502)GGA>GTA	p.G834V	RIMS2_uc003ylp.2_Missense_Mutation_p.G1094V|RIMS2_uc003ylw.2_Missense_Mutation_p.G908V|RIMS2_uc003ylq.2_Missense_Mutation_p.G908V|RIMS2_uc003ylr.2_Missense_Mutation_p.G933V	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1156					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCAGTCGCAGGACGAAGGGGC	0.438										HNSCC(12;0.0054)			21	26					4.63292e-17	6.79495e-17	1	0	T	105026790	T	T	105026790	3	4	213	1	0	0	0	0	1	0	0	0	13433	1174	41	2	3551	2	RIMS2	8	105026790	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	9162921	105026790	41337232	95	38782											
COL22A1	169044	broad.mit.edu	37	chr8	139890335	139890335	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccgtggtaggcgagacgccGggcagccgccttgacctcct	5	6	14	16	5	0	2	0	1	0	1	1	3	1	2	6	3	1	2	6	3	1	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr8:139890335G>A	uc003yvd.2	-	3	763	c.316C>T	c.(316-318)CGG>TGG	p.R106W		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	106	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GCGAGACGCCGGGCAGCCGCC	0.716										HNSCC(7;0.00092)			16	4					0	0	0	0	A	139890335	A	A	139890335	3	1	213	1	0	0	0	0	1	0	0	0	3696	1115	39	1	4816	1	COL22A1	8	139890335	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	34863545	139890335	6473687	96	38783											
DMRT3	58524	broad.mit.edu	37	chr9	990980	990980	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggtctgactcctcagactCtagaacactcaacacatcat	13	9	6	13	0	5	3	3	1	2	2	6	4	6	3	1	1	2	0	1	1	3	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:990980C>G	uc003zgw.1	+	2	1432	c.1394C>G	c.(1393-1395)TCT>TGT	p.S465C		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	465					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		TCCTCAGACTCTAGAACACTC	0.512													32	39					0	0	0	0	G	990980	G	G	990980	3	3	213	1	0	0	0	0	1	0	0	0	4609	913	32	2	1400	2	DMRT3	9	990980	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08		990980	140222451	97	38784											
ARID3C	138715	broad.mit.edu	37	chr9	34622436	34622436	+	Frame_Shift_Del	DEL	G	-	-																															tcagcacagctctcttctctGggggctcctctggtgccaat																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:34622436delG	uc011lon.1	-	5	956	c.956delC	c.(955-957)CCAfs	p.P319fs	DCTN3_uc003zuw.1_5'Flank|DCTN3_uc003zux.1_5'Flank	NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	319	REKLES.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		TCTCTTCTCTGGGGGCTCCTC	0.607													---	---	---								-	34622436	-	-	34622436	7	5	213	1	0	1	0	1	0	0	0	0	918	1348	47	0	293	0	ARID3C	9	34622436	Frame_Shift_Del	DEL	G	TCGA-CV-6960-01A-41D-2012-08	33631456	34622436	106590995	98	38785											
TRPM6	140803	broad.mit.edu	37	chr9	77403655	77403655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catgaggaatgccaaatacgCcatctgtgagggggacacac	13	6	12	10	1	1	2	0	2	1	0	1	4	1	4	2	3	2	0	2	3	3	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:77403655C>T	uc004ajl.1	-	20	2780	c.2542G>A	c.(2542-2544)GCG>ACG	p.A848T	TRPM6_uc004ajk.1_Missense_Mutation_p.A843T|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	848	Helical; (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GCCAAATACGCCATCTGTGAG	0.532													6	30					0	0	0	0	T	77403655	T	T	77403655	3	4	213	1	0	0	0	0	1	0	0	0	16657	739	26	4	3606	4	TRPM6	9	77403655	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	42781219	77403655	63809776	99	38786											
FGD3	89846	broad.mit.edu	37	chr9	95795123	95795123	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtctgcagagattgtttcCtgacacagccagtggcccct	7	11	11	12	0	1	2	0	1	1	1	2	3	2	2	4	1	2	2	4	1	0	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:95795123C>A	uc004asw.2	+	16	2381	c.1753C>A	c.(1753-1755)CTG>ATG	p.L585M	FGD3_uc004asx.2_Missense_Mutation_p.L585M|FGD3_uc004asz.2_Missense_Mutation_p.L585M|FGD3_uc011luc.1_Missense_Mutation_p.L188M	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	585	FYVE-type.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						AGATTGTTTCCTGACACAGCC	0.637													42	112					2.45108e-15	3.44861e-15	1	0	A	95795123	A	A	95795123	3	1	213	1	0	0	0	0	1	0	0	0	5866	680	24	4	1807	4	FGD3	9	95795123	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	18391468	95795123	45418308	100	38787											
TBC1D2	55357	broad.mit.edu	37	chr9	100963875	100963875	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acgagggagagatccacgtgGtgctgccccagatgggccat	9	6	15	11	2	0	2	0	0	0	2	1	5	1	3	4	3	2	1	4	3	0	0	rs148540803	by1000genomes	TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:100963875G>T	uc011lvb.1	-	11	2523	c.2343C>A	c.(2341-2343)CAC>CAA	p.H781Q	TBC1D2_uc004ayp.2_Missense_Mutation_p.H321Q|TBC1D2_uc004ayq.2_Missense_Mutation_p.H781Q|TBC1D2_uc004ayr.2_Missense_Mutation_p.H563Q|TBC1D2_uc004ayo.3_Missense_Mutation_p.H781Q	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	781	Rab-GAP TBC.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		GATCCACGTGGTGCTGCCCCA	0.607													19	54					1.96292e-10	2.4741e-10	1	0	T	100963875	T	T	100963875	3	4	213	1	0	0	0	0	1	0	0	0	15674	1252	44	4	422	4	TBC1D2	9	100963875	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	5168752	100963875	40249556	101	38788											
GRIN3A	116443	broad.mit.edu	37	chr9	104499694	104499694	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcgccgacaccccttgcaCcaccacggtatggcacacac	10	4	8	19	3	0	0	0	0	0	0	0	1	0	0	5	2	2	3	5	2	1	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:104499694C>T	uc004bbp.1	-	1	1169	c.568G>A	c.(568-570)GTG>ATG	p.V190M	GRIN3A_uc004bbq.1_Missense_Mutation_p.V190M	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	190	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	ACCCCTTGCACCACCACGGTA	0.587													17	45					0	0	0	0	T	104499694	T	T	104499694	3	4	213	1	0	0	0	0	1	0	0	0	6822	507	18	4	2815	4	GRIN3A	9	104499694	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	3535819	104499694	36713737	102	38789											
OR13F1	138805	broad.mit.edu	37	chr9	107267065	107267066	+	Frame_Shift_Ins	INS	-	A	A																															tctgtggtaatagcatcatcINSaatcatttcacttgtgaaat																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:107267065_107267066insA	uc011lvm.1	+	1	522_523	c.522_523insA	c.(520-525)ATCAATfs	p.I174fs		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	174_175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						ATAGCATCATCAATCATTTCAC	0.48													---	---	---								A	107267066	A	A	107267065	7	5	213	1	0	1	1	0	0	0	0	0	10995	816	29	0	524	0	OR13F1	9	107267065	Frame_Shift_Ins	INS	-	TCGA-CV-6960-01A-41D-2012-08	2767371	107267065	33946366	103	38790											
FKTN	2218	broad.mit.edu	37	chr9	108366711	108366711	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagacttaaagaacacatTgacaggaaatttgttccctt	14	13	7	7	0	0	3	0	2	0	2	1	5	1	4	1	1	1	1	1	1	4	6			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:108366711T>A	uc004bcr.2	+	6	801	c.585T>A	c.(583-585)ATT>ATA	p.I195I	FKTN_uc011lvx.1_Silent_p.I195I|FKTN_uc004bcs.2_Silent_p.I195I|FKTN_uc011lvy.1_Silent_p.I195I|FKTN_uc010mtm.2_Silent_p.I63I	NM_001079802	NP_001073270	O75072	FKTN_HUMAN	fukutin	195	Lumenal (Potential).				muscle organ development|negative regulation of cell proliferation|negative regulation of JNK cascade|nervous system development|regulation of protein glycosylation	cis-Golgi network|endoplasmic reticulum|extracellular space|Golgi membrane|integral to membrane|nucleus	transferase activity			breast(2)|ovary(1)	3						AAGAACACATTGACAGGAAAT	0.443													16	34					0	0	0	0	A	108366711	A	A	108366711	2	1	213	1	0	0	0	0	0	0	0	1	5951	1800	63	5		5	FKTN	9	108366711	Silent	SNP	T	TCGA-CV-6960-01A-41D-2012-08	1099646	108366711	32846720	104	38791											
SVEP1	79987	broad.mit.edu	37	chr9	113169643	113169643	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagagcctgctagaatgtgtCcaggtttacagctatactgc	10	11	10	10	0	0	2	0	0	0	2	1	2	1	2	2	1	6	3	2	1	5	5			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:113169643C>A	uc010mtz.2	-	38	8574	c.8237G>T	c.(8236-8238)GGA>GTA	p.G2746V	SVEP1_uc010mty.2_Missense_Mutation_p.G672V	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2746	Sushi 22.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TAGAATGTGTCCAGGTTTACA	0.443													28	65					1.26454e-06	1.45033e-06	1	0	A	113169643	A	A	113169643	3	1	213	1	0	0	0	0	1	0	0	0	15486	855	30	2	2522	2	SVEP1	9	113169643	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	4802932	113169643	28043788	105	38792											
FCN2	2220	broad.mit.edu	37	chr9	137772670	137772670	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagcaaagaccagaagagatGgagctggacagagctgtggg	15	4	16	6	0	0	4	0	0	0	4	0	7	0	6	1	3	3	3	1	3	3	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:137772670G>T	uc004cfg.1	+	1	13	c.3G>T	c.(1-3)ATG>ATT	p.M1I	FCN2_uc004cfh.1_Missense_Mutation_p.M1I	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	1					complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		CAGAAGAGATGGAGCTGGACA	0.592													14	29					6.31663e-08	7.53017e-08	1	0	T	137772670	T	T	137772670	3	4	213	1	0	0	0	0	1	0	0	0	5824	1348	47	4	5	4	FCN2	9	137772670	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	24603027	137772670	3440761	106	38793											
PNPLA7	375775	broad.mit.edu	37	chr9	140438232	140438232	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccgctgccggggcagggcAgtgttctccacaagggtgtt	5	8	16	12	2	1	0	0	0	1	0	2	0	1	0	3	4	1	5	3	4	1	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr9:140438232A>C	uc004cnf.2	-	4	571	c.234T>G	c.(232-234)ACT>ACG	p.T78T	PNPLA7_uc010ncj.1_Silent_p.T103T	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	78					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GGGGCAGGGCAGTGTTCTCCA	0.622													21	64					0	0	0	0	C	140438232	C	C	140438232	2	2	213	1	0	0	0	0	0	0	0	1	12225	175	7	5		5	PNPLA7	9	140438232	Silent	SNP	A	TCGA-CV-6960-01A-41D-2012-08	2665562	140438232	775199	107	38794											
C10orf47	254427	broad.mit.edu	37	chr10	11911812	11911812	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccccgcagtggagaccctGgcccggggcccagccacccg	5	2	15	19	3	0	1	0	0	0	1	0	2	0	1	7	5	1	1	7	5	0	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr10:11911812G>T	uc001ikx.2	+	4	869	c.715G>T	c.(715-717)GGC>TGC	p.G239C	uc001iky.1_Intron	NM_153256	NP_694988	Q86WR7	CJ047_HUMAN	hypothetical protein LOC254427	239	Pro-rich.									central_nervous_system(1)	1						TGGAGACCCTGGCCCGGGGCC	0.766													9	14					3.09899e-07	3.60555e-07	1	0	T	11911812	T	T	11911812	3	4	213	1	0	0	0	0	1	0	0	0	1611	1348	47	4	725	4	C10orf47	10	11911812	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08		11911812	123622935	108	38795											
HSPA14	51182	broad.mit.edu	37	chr10	14894529	14894529	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atctagcttctgagttccaaAggtgagtgttaatggcctga	10	13	11	7	0	2	3	0	3	2	0	3	3	3	3	2	2	1	3	2	2	3	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr10:14894529A>T	uc001inf.2	+	8	874	c.733A>T	c.(733-735)AGA>TGA	p.R245*		NM_016299	NP_057383	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14 isoform 1	245					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			ovary(2)|breast(2)|lung(1)	5						TGAGTTCCAAAGGTGAGTGTT	0.358													30	61					0	0	0	0	T	14894529	T	T	14894529	4	4	213	1	0	0	0	0	0	1	0	0	7446	86	3	5	763	5	HSPA14	10	14894529	Nonsense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	2982717	14894529	120640218	109	38796											
SLC39A12	221074	broad.mit.edu	37	chr10	18331685	18331685	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccctggatgatgtttctcCtgcaaaactttggattgatc	9	14	9	9	0	1	2	0	2	1	0	3	5	1	4	2	2	2	2	2	2	2	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr10:18331685C>A	uc001ipo.2	+	13	2272	c.1999C>A	c.(1999-2001)CTG>ATG	p.L667M	SLC39A12_uc001ipn.2_Missense_Mutation_p.L630M|SLC39A12_uc001ipp.2_Missense_Mutation_p.L666M|SLC39A12_uc010qck.1_Missense_Mutation_p.L533M	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	667	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						GATGTTTCTCCTGCAAAACTT	0.353													16	61					6.94344e-10	8.70629e-10	1	0	A	18331685	A	A	18331685	3	1	213	1	0	0	0	0	1	0	0	0	14679	680	24	4	2045	4	SLC39A12	10	18331685	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	3437156	18331685	117203062	110	38797											
RASGEF1A	221002	broad.mit.edu	37	chr10	43691705	43691705	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccgcctcaggctctgttcAgaagggtggtcctagagggg	7	9	15	10	1	3	2	2	0	1	2	5	2	5	2	3	5	0	2	3	5	2	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr10:43691705A>T	uc001jap.1	-	13	1514	c.1433T>A	c.(1432-1434)CTG>CAG	p.L478Q	RASGEF1A_uc001jao.1_Missense_Mutation_p.L486Q	NM_145313	NP_660356	Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	478					cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						GGCTCTGTTCAGAAGGGTGGT	0.597													27	66					0	0	0	0	T	43691705	T	T	43691705	3	4	213	1	0	0	0	0	1	0	0	0	13134	188	7	5	16	5	RASGEF1A	10	43691705	Missense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	25360020	43691705	91843042	111	38798											
RHOBTB1	9886	broad.mit.edu	37	chr10	62648784	62648784	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtgggatttccagaattgCaggtgcctgcgggaaatcag	10	9	15	7	1	1	1	1	0	0	1	2	3	2	3	2	4	3	1	2	4	2	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr10:62648784C>T	uc001jli.2	-	7	1080	c.642G>A	c.(640-642)CTG>CTA	p.L214L	RHOBTB1_uc001jlh.2_Silent_p.L214L|RHOBTB1_uc001jlj.2_Silent_p.L214L|RHOBTB1_uc001jlk.2_Silent_p.L214L|RHOBTB1_uc009xpe.1_Silent_p.L152L|RHOBTB1_uc001jll.2_5'UTR	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	214					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					TCCAGAATTGCAGGTGCCTGC	0.473													64	229					0	0	0	0	T	62648784	T	T	62648784	2	4	213	1	0	0	0	0	0	0	0	1	13398	697	25	4		4	RHOBTB1	10	62648784	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	18957079	62648784	72885963	112	38799											
SFTPA2	729238	broad.mit.edu	37	chr10	81319105	81319105	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttgacaccatctctcccGtccctgcctggcaggccgtg	4	10	9	18	2	1	1	0	1	1	0	4	1	3	1	6	2	1	1	6	2	0	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr10:81319105G>T	uc001kal.3	-	3	232	c.135C>A	c.(133-135)GAC>GAA	p.D45E	SFTPA2_uc001kan.3_Missense_Mutation_p.D45E|SFTPA2_uc001kam.2_RNA	NM_006926	NP_008857	Q8IWL1	SFPA2_HUMAN	RecName: Full=Pulmonary surfactant-associated protein A2;          Short=SP-A2;          Short=SP-A;          Short=PSP-A;          Short=PSPA; AltName: Full=Alveolar proteinosis protein; AltName: Full=35 kDa pulmonary surfactant-associated protein; Flags: Precursor;	45	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			CATCTCTCCCGTCCCTGCCTG	0.622									Pulmonary_Fibrosis_Idiopathic				28	142					2.68265e-12	3.56704e-12	1	0	T	81319105	T	T	81319105	3	4	213	1	0	0	0	0	1	0	0	0	14255	1136	40	3	627	3	SFTPA2	10	81319105	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	18670321	81319105	54215642	113	38800											
PNLIPRP1	5407	broad.mit.edu	37	chr10	118357567	118357567	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taagcatttcaggttttggaAcgaaccaacagatgggtcat	13	11	10	7	1	2	1	2	0	0	1	2	3	2	2	1	3	4	2	1	3	4	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr10:118357567A>G	uc001lco.1	+	8	721	c.703A>G	c.(703-705)ACG>GCG	p.T235A	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.T235A	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	235					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		AGGTTTTGGAACGAACCAACA	0.463													23	15					0	0	0	0	G	118357567	G	G	118357567	3	3	213	1	0	0	0	0	1	0	0	0	12205	43	2	5	729	5	PNLIPRP1	10	118357567	Missense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	37038462	118357567	17177180	114	38801											
TUBGCP2	10844	broad.mit.edu	37	chr10	135099030	135099030	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcctccaggccgctcagcgCcagctccgtggggtcggcgt	3	6	16	16	5	1	0	1	0	0	0	4	0	3	0	5	5	2	2	5	5	0	0	rs142228780	byFrequency	TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr10:135099030C>T	uc001lmg.1	-	12	2182	c.1825G>A	c.(1825-1827)GCG>ACG	p.A609T	TUBGCP2_uc001lmf.1_Missense_Mutation_p.A202T|TUBGCP2_uc010qvc.1_Missense_Mutation_p.A637T|TUBGCP2_uc009ybk.1_Intron|TUBGCP2_uc010qvd.1_Missense_Mutation_p.A479T|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	609					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		CCGCTCAGCGCCAGCTCCGTG	0.642													20	19					0	0	0	0	T	135099030	T	T	135099030	3	4	213	1	0	0	0	0	1	0	0	0	16834	739	26	4	911	4	TUBGCP2	10	135099030	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	16741463	135099030	435717	115	38802											
OR56B1	387748	broad.mit.edu	37	chr11	5758676	5758676	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accaaagaacttagggcagcCttccaaaaggtgctgtttgc	12	9	10	10	0	0	1	0	0	0	1	1	1	1	1	3	2	4	3	3	2	5	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:5758676C>T	uc001mbt.1	+	1	930	c.930C>T	c.(928-930)GCC>GCT	p.A310A	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		TTAGGGCAGCCTTCCAAAAGG	0.418													44	107					0	0	0	0	T	5758676	T	T	5758676	2	4	213	1	0	0	0	0	0	0	0	1	11191	668	24	4		4	OR56B1	11	5758676	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08		5758676	129247840	116	38803											
OR56A1	120796	broad.mit.edu	37	chr11	6048915	6048915	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtggagctgttgctgggtGacgccataggctgaatcatg	8	10	15	8	1	1	2	1	2	0	0	1	3	1	3	1	3	2	4	1	3	2	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:6048915G>T	uc010qzw.1	-	1	20	c.20C>A	c.(19-21)TCA>TAA	p.S7*		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTTGCTGGGTGACGCCATAGG	0.488													38	101					1.47197e-15	2.09539e-15	1	0	T	6048915	T	T	6048915	4	4	213	1	0	0	0	0	0	1	0	0	11187	1294	45	2	940	2	OR56A1	11	6048915	Nonsense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	290239	6048915	128957601	117	38804											
SLC5A12	159963	broad.mit.edu	37	chr11	26725200	26725200	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccaaaaagtgtgtcgcctGagaggatctacatcaaagct	13	9	10	9	1	2	1	1	1	1	1	4	3	3	2	2	1	2	1	2	1	4	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:26725200G>A	uc001mra.2	-	6	1012	c.699C>T	c.(697-699)CTC>CTT	p.L233L	SLC5A12_uc001mrb.2_RNA|SLC5A12_uc001mrc.3_Silent_p.L233L	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	233	Extracellular (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						TGTGTCGCCTGAGAGGATCTA	0.403													29	49					0	0	0	0	A	26725200	A	A	26725200	2	1	213	1	0	0	0	0	0	0	0	1	14728	1277	45	2		2	SLC5A12	11	26725200	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	20676285	26725200	108281316	118	38805											
LRRC4C	57689	broad.mit.edu	37	chr11	40136945	40136945	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttacagttccaagggttgtGatgtaaatgtatccgctcta	10	14	10	7	1	1	1	0	1	1	0	3	1	3	1	2	1	1	6	2	1	6	6			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:40136945G>C	uc001mxa.1	-	2	2862	c.898C>G	c.(898-900)CAC>GAC	p.H300D	LRRC4C_uc001mxc.1_Missense_Mutation_p.H296D|LRRC4C_uc001mxd.1_Missense_Mutation_p.H296D|LRRC4C_uc001mxb.1_Missense_Mutation_p.H296D	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	300					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CAAGGGTTGTGATGTAAATGT	0.478													32	62					0	0	0	0	C	40136945	C	C	40136945	3	2	213	1	0	0	0	0	1	0	0	0	9058	1290	45	2	1028	2	LRRC4C	11	40136945	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	13411745	40136945	94869571	119	38806											
PRDM11	56981	broad.mit.edu	37	chr11	45241231	45241231	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccggcctggggagtggctgcGggtctggtacagcgaggact	5	7	19	10	3	1	0	0	0	1	0	1	3	1	2	2	7	3	2	2	7	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:45241231G>A	uc001myo.2	+	7	1016	c.767G>A	c.(766-768)CGG>CAG	p.R256Q		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	256	SET.									upper_aerodigestive_tract(1)	1						GAGTGGCTGCGGGTCTGGTAC	0.622													11	29					0	0	0	0	A	45241231	A	A	45241231	3	1	213	1	0	0	0	0	1	0	0	0	12514	1116	39	1	789	1	PRDM11	11	45241231	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	5104286	45241231	89765285	120	38807											
KBTBD4	55709	broad.mit.edu	37	chr11	47598968	47598971	+	Frame_Shift_Del	DEL	ATGA	-	-																															cctccctaaacttacccgagAtgatatctgtgagtaagcgg																								rs149725159		TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:47598968_47598971delATGA	uc001nfx.2	-	2	752_755	c.581_584delTCAT	c.(580-585)ATCATCfs	p.I194fs	NDUFS3_uc001nft.3_Intron|KBTBD4_uc001nfw.1_Frame_Shift_Del_p.I219fs|KBTBD4_uc001nfz.2_Frame_Shift_Del_p.I210fs|KBTBD4_uc001nfy.2_Frame_Shift_Del_p.I194fs|NDUFS3_uc010rhn.1_5'Flank|NDUFS3_uc001nga.2_5'Flank	NM_016506	NP_057590	Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	194_195	BACK.			I -> T (in Ref. 1; BAA91616).						ovary(1)|central_nervous_system(1)	2						CTTACCCGAGATGATATCTGTGAG	0.5													---	---	---								-	47598971	-	-	47598968	7	5	213	1	0	1	0	1	0	0	0	0	8034	333	12	0	984	0	KBTBD4	11	47598968	Frame_Shift_Del	DEL	ATGA	TCGA-CV-6960-01A-41D-2012-08	2357737	47598968	87407548	121	38808											
OR4A15	81328	broad.mit.edu	37	chr11	55136211	55136211	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctttgtcccctgtatcttCttgtatgcaaggcccaattc	6	17	6	12	0	3	0	0	0	3	0	5	0	4	0	3	1	1	3	3	1	4	7			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:55136211C>A	uc010rif.1	+	1	852	c.852C>A	c.(850-852)TTC>TTA	p.F284L		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	284	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCTGTATCTTCTTGTATGCAA	0.408													51	214					5.39261e-20	8.05563e-20	1	0	A	55136211	A	A	55136211	3	1	213	1	0	0	0	0	1	0	0	0	11094	912	32	2	854	2	OR4A15	11	55136211	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	7537243	55136211	79870305	122	38809											
POLA2	23649	broad.mit.edu	37	chr11	65048604	65048604	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgagcttaaggaatattctCtgtttcctggacaggtgaga	10	13	11	7	0	1	2	0	2	1	1	3	5	2	4	1	3	1	2	1	3	3	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:65048604C>G	uc001odj.2	+	8	1228	c.886C>G	c.(886-888)CTG>GTG	p.L296V	POLA2_uc010rod.1_Missense_Mutation_p.L88V|POLA2_uc001odk.2_5'UTR	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	296					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	GGAATATTCTCTGTTTCCTGG	0.517													36	122					0	0	0	0	G	65048604	G	G	65048604	3	3	213	1	0	0	0	0	1	0	0	0	12243	912	32	2	916	2	POLA2	11	65048604	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	9912393	65048604	69957912	123	38810											
ADRBK1	156	broad.mit.edu	37	chr11	67051732	67051732	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacttccccctcaccatctcGgagcggtggcagcaggaggt	8	7	12	14	2	2	0	1	0	1	0	4	2	3	2	3	5	3	2	3	5	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:67051732G>A	uc009yrn.1	+	18	1808	c.1542G>A	c.(1540-1542)TCG>TCA	p.S514S	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	514	AGC-kinase C-terminal.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	TCACCATCTCGGAGCGGTGGC	0.592													49	78					0	0	0	0	A	67051732	A	A	67051732	2	1	213	1	0	0	0	0	0	0	0	1	343	1103	39	1		1	ADRBK1	11	67051732	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	2003128	67051732	67954784	124	38811											
NCAM1	4684	broad.mit.edu	37	chr11	113076802	113076802	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccaacaactacctgcagatCcggggcatcaagaaaacaga	16	5	8	12	1	1	3	1	0	0	3	3	3	3	3	3	2	5	2	3	2	6	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:113076802C>A	uc009yyq.1	+	5	868	c.174C>A	c.(172-174)ATC>ATA	p.I58I	NCAM1_uc001pno.2_Silent_p.I58I	NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	176	Ig-like C2-type 2.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		ACCTGCAGATCCGGGGCATCA	0.507													25	153					5.35356e-11	6.96538e-11	1	0	A	113076802	A	A	113076802	2	1	213	1	0	0	0	0	0	0	0	1	10256	845	30	2		2	NCAM1	11	113076802	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	46025070	113076802	21929714	125	38812											
ZW10	9183	broad.mit.edu	37	chr11	113639651	113639651	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctgcatgctaggcaggaaTtcactgtacttcttgctaat	9	14	8	10	0	3	0	1	0	2	0	3	1	3	1	0	2	4	5	0	2	4	6			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:113639651T>A	uc001poe.2	-	2	181	c.144A>T	c.(142-144)GAA>GAT	p.E48D	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	48	Interaction with RINT1.|Interaction with ZWINT.|Potential.				cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TAGGCAGGAATTCACTGTACT	0.403													62	66					0	0	0	0	A	113639651	A	A	113639651	3	1	213	1	0	0	0	0	1	0	0	0	18314	1490	52	5	2255	5	ZW10	11	113639651	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	562849	113639651	21366865	126	38813											
CEP164	22897	broad.mit.edu	37	chr11	117282544	117282544	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcctacagcactcccattcGcaagtccctgaggcgggcag	8	7	10	16	2	0	1	0	1	0	0	4	1	3	1	3	2	2	3	3	2	2	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:117282544G>A	uc001prc.2	+	32	4344	c.4197G>A	c.(4195-4197)TCG>TCA	p.S1399S	CEP164_uc001prb.2_Silent_p.S1394S|CEP164_uc001prf.2_RNA|CEP164_uc009yzp.1_RNA	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1399					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		ACTCCCATTCGCAAGTCCCTG	0.582													5	120					0	0	0	0	A	117282544	A	A	117282544	2	1	213	1	0	0	0	0	0	0	0	1	3264	1074	38	1		1	CEP164	11	117282544	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	3642893	117282544	17723972	127	38814											
VPS11	55823	broad.mit.edu	37	chr11	118949031	118949033	+	In_Frame_Del	DEL	AGA	-	-																															actgcagaactgggcccacgAgaaggatccacaggtgaggc																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:118949031_118949033delAGA	uc010ryx.1	+	12	1952_1954	c.1910_1912delAGA	c.(1909-1914)GAGAAG>GAG	p.K638del	VPS11_uc010ryy.1_In_Frame_Del_p.K484del	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	638					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		TGGGCCCACGAGAAGGATCCACA	0.562													---	---	---								-	118949033	-	-	118949031	7	5	213	1	0	1	0	1	0	0	0	0	17256	304	11	0	1951	0	VPS11	11	118949031	In_Frame_Del	DEL	AGA	TCGA-CV-6960-01A-41D-2012-08	1666487	118949031	16057485	128	38815											
NTM	50863	broad.mit.edu	37	chr11	132016264	132016264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgacaagtggtgcctggatCctcgcgtggtccttctgagc	6	11	13	11	2	1	2	0	2	1	0	4	3	3	3	3	3	2	0	3	3	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr11:132016264C>T	uc001qgp.2	+	2	920	c.256C>T	c.(256-258)CCT>TCT	p.P86S	NTM_uc001qgm.2_Missense_Mutation_p.P86S|NTM_uc010sch.1_Missense_Mutation_p.P77S|NTM_uc010sci.1_Missense_Mutation_p.P86S|NTM_uc010scj.1_Missense_Mutation_p.P45S|NTM_uc001qgo.2_Missense_Mutation_p.P86S|NTM_uc001qgq.2_Missense_Mutation_p.P86S	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	86	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						GTGCCTGGATCCTCGCGTGGT	0.572													21	71					0	0	0	0	T	132016264	T	T	132016264	3	4	213	1	0	0	0	0	1	0	0	0	10753	855	30	2	348	2	NTM	11	132016264	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	13067233	132016264	2990252	129	38816											
DYRK4	8798	broad.mit.edu	37	chr12	4721873	4721873	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggttcaaggctgtcatcactCgagcagaaaaggtacagcct	12	8	11	10	1	3	1	3	0	0	1	4	2	3	1	1	3	3	4	1	3	4	2	rs141423818	by1000genomes	TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:4721873C>G	uc001qmx.2	+	12	1470	c.1310C>G	c.(1309-1311)TCG>TGG	p.S437W	DYRK4_uc009zeh.1_Missense_Mutation_p.S552W|DYRK4_uc001qmy.1_Missense_Mutation_p.S437W|DYRK4_uc001qmz.1_Missense_Mutation_p.S151W|DYRK4_uc001qna.1_Missense_Mutation_p.S74W|DYRK4_uc010ser.1_Missense_Mutation_p.S74W	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	437						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			TGTCATCACTCGAGCAGAAAA	0.468													42	49					0	0	0	0	G	4721873	G	G	4721873	3	3	213	1	0	0	0	0	1	0	0	0	4880	893	31	3	1348	3	DYRK4	12	4721873	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08		4721873	129130022	130	38817											
CD27	939	broad.mit.edu	37	chr12	6559460	6559466	+	Frame_Shift_Del	DEL	TCGGTCG	-	-																															ccaaacccttcgctgaccgcTcggtcgtctcaggccctgag																								rs150578547	byFrequency	TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:6559460_6559466delTCGGTCG	uc001qod.2	+	3	601_607	c.390_396delTCGGTCG	c.(388-396)GCTCGGTCGfs	p.A130fs	LOC678655_uc001qob.2_Intron|LOC678655_uc001qoc.2_Intron|LOC678655_uc009zel.1_Intron|CD27_uc001qoe.2_5'UTR|LOC678655_uc009zem.1_Intron|LOC678655_uc001qof.2_Intron|TAPBPL_uc001qog.3_5'Flank|TAPBPL_uc001qoh.3_5'Flank|TAPBPL_uc001qoi.1_5'Flank	NM_001242	NP_001233	P26842	CD27_HUMAN	tumor necrosis factor receptor superfamily,	130_132	Extracellular (Potential).|TNFR-Cys 3.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity				0						CGCTGACCGCTCGGTCGTCTCAGGCCC	0.585													---	---	---								-	6559466	-	-	6559460	7	5	213	1	0	1	0	1	0	0	0	0	3005	1538	54	0	400	0	CD27	12	6559460	Frame_Shift_Del	DEL	TCGGTCG	TCGA-CV-6960-01A-41D-2012-08	1837587	6559460	127292435	131	38818											
TPI1	7167	broad.mit.edu	37	chr12	6976735	6976735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcggctccagcgccatggCgccctccaggaagttcttcg	5	8	11	17	4	1	0	0	0	1	0	5	1	3	1	5	3	1	2	5	3	1	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:6976735C>T	uc001qrk.2	+	1	43	c.5C>T	c.(4-6)GCG>GTG	p.A2V	TPI1_uc010sfo.1_5'Flank	NM_000365	NP_000356	P60174	TPIS_HUMAN	triosephosphate isomerase 1 isoform 1	2					fatty acid biosynthetic process|gluconeogenesis|glycolysis|pentose-phosphate shunt	cytosol	triose-phosphate isomerase activity				0						AGCGCCATGGCGCCCTCCAGG	0.597													8	18					0	0	0	0	T	6976735	T	T	6976735	3	4	213	1	0	0	0	0	1	0	0	0	16470	768	27	1	118	1	TPI1	12	6976735	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	417275	6976735	126875160	132	38819											
DPPA3	359787	broad.mit.edu	37	chr12	7864234	7864234	+	Frame_Shift_Del	DEL	C	-	-																															aatgctcaccgaagaaaattCccgggacgattcaggtaagc																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:7864234delC	uc001qtf.2	+	1	146	c.68delC	c.(67-69)TCCfs	p.S23fs		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	23						cytoplasm|nucleus					0				Kidney(36;0.0887)		GAAGAAAATTCCCGGGACGAT	0.468													---	---	---								-	7864234	-	-	7864234	7	5	213	1	0	1	0	1	0	0	0	0	4757	855	30	0	70	0	DPPA3	12	7864234	Frame_Shift_Del	DEL	C	TCGA-CV-6960-01A-41D-2012-08	887499	7864234	125987661	133	38820											
PRB1	5542	broad.mit.edu	37	chr12	11506584	11506584	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctttcctggaggagatcaGggacttcgggacttgtctcc	6	11	14	10	1	2	1	1	0	1	1	5	5	3	4	2	5	0	1	2	5	0	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:11506584G>T	uc001qzw.1	-	3	490	c.453C>A	c.(451-453)CCC>CCA	p.P151P	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	212	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].|8.		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GAGGAGATCAGGGACTTCGGG	0.612													142	552					6.51847e-42	1.01772e-41	1	0	T	11506584	T	T	11506584	2	4	213	1	0	0	0	0	0	0	0	1	12504	987	35	4		4	PRB1	12	11506584	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	3642350	11506584	122345311	134	38821											
ARID2	196528	broad.mit.edu	37	chr12	46215209	46215209	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tatttgttttttagctttagGatccttttccactgtatttg	6	23	6	6	0	0	0	0	0	0	0	2	1	2	1	2	1	1	3	2	1	4	11			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:46215209G>T	uc001ros.1	+	6	644	c.644G>T	c.(643-645)GGA>GTA	p.G215V	ARID2_uc001ror.2_Missense_Mutation_p.G215V	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	215					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTAGCTTTAGGATCCTTTTCC	0.254													13	56					9.05144e-12	1.19046e-11	1	0	T	46215209	T	T	46215209	3	4	213	1	0	0	0	0	1	0	0	0	915	1174	41	2	666	2	ARID2	12	46215209	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	34708625	46215209	87636686	135	38822											
SDR9C7	121214	broad.mit.edu	37	chr12	57323300	57323300	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgatagttccctggctcaaTgatgcagactttcaccccaa	10	10	7	14	1	2	2	2	1	0	1	3	3	3	2	4	1	1	3	4	1	3	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:57323300T>C	uc010sqw.1	-	3	598	c.598A>G	c.(598-600)ATT>GTT	p.I200V		NM_148897	NP_683695	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C,	200						cytoplasm	binding|oxidoreductase activity			central_nervous_system(1)	1						CCTGGCTCAATGATGCAGACT	0.552													31	33					0	0	0	0	C	57323300	C	C	57323300	3	2	213	1	0	0	0	0	1	0	0	0	14039	1464	51	5	351	5	SDR9C7	12	57323300	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	11108091	57323300	76528595	136	38823											
LRP1	4035	broad.mit.edu	37	chr12	57550688	57550688	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcttcagcctgggcagtgacGggaagtcatgcaagagtgag	10	7	16	8	1	2	3	2	2	0	1	2	4	2	4	1	2	2	3	1	2	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:57550688G>A	uc001snd.2	+	10	2012	c.1546G>A	c.(1546-1548)GGG>AGG	p.G516R		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	516	EGF-like 3.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGGCAGTGACGGGAAGTCATG	0.657													3	10					0	0	0	0	A	57550688	A	A	57550688	3	1	213	1	0	0	0	0	1	0	0	0	9001	1116	39	1	1584	1	LRP1	12	57550688	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	227388	57550688	76301207	137	38824											
RBM19	9904	broad.mit.edu	37	chr12	114261056	114261056	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagggtctgctcctcgctGtcgctgtcactgccttccag	4	12	11	14	2	2	1	1	1	1	0	6	1	4	1	3	1	2	3	3	1	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:114261056G>A	uc009zwi.2	-	24	3000	c.2856C>T	c.(2854-2856)GAC>GAT	p.D952D	RBM19_uc001tvn.3_Silent_p.D952D|RBM19_uc001tvm.2_Silent_p.D952D	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	952					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GCTCCTCGCTGTCGCTGTCAC	0.637													16	32					0	0	0	0	A	114261056	A	A	114261056	2	1	213	1	0	0	0	0	0	0	0	1	13186	1368	48	4		4	RBM19	12	114261056	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	56710368	114261056	19590839	138	38825											
GPR109B	8843	broad.mit.edu	37	chr12	123200755	123200755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcagatgctgaagctgatgCacacatttgcagtgccattc	10	10	11	10	0	0	3	0	2	0	1	1	3	0	3	1	1	5	5	1	1	1	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:123200755C>T	uc001ucy.3	-	1	685	c.530G>A	c.(529-531)TGC>TAC	p.C177Y	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	177	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	GAAGCTGATGCACACATTTGC	0.537													29	53					0	0	0	0	T	123200755	T	T	123200755	3	4	213	1	0	0	0	0	1	0	0	0	6664	710	25	4	637	4	GPR109B	12	123200755	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	8939699	123200755	10651140	139	38826											
GTF2H3	2967	broad.mit.edu	37	chr12	124132650	124132650	+	Frame_Shift_Del	DEL	A	-	-																															aaatgaagttattgttgaagAgattaaagatctaatgacca																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr12:124132650delA	uc001ufo.1	+	4	367	c.341delA	c.(340-342)GAGfs	p.E114fs	GTF2H3_uc010tau.1_Frame_Shift_Del_p.E73fs	NM_001516	NP_001507	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3,	114					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		ATTGTTGAAGAGATTAAAGAT	0.348								NER					---	---	---								-	124132650	-	-	124132650	7	5	213	1	0	1	0	1	0	0	0	0	6903	304	11	0	355	0	GTF2H3	12	124132650	Frame_Shift_Del	DEL	A	TCGA-CV-6960-01A-41D-2012-08	931895	124132650	9719245	140	38827											
DCLK1	9201	broad.mit.edu	37	chr13	36700222	36700222	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accctcggctgtatctctgcGccttatcccgctcgtcgaag	5	11	9	16	5	1	0	0	0	1	0	6	1	2	0	3	1	1	3	3	1	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr13:36700222G>A	uc001uvf.2	-	2	286	c.53C>T	c.(52-54)GCG>GTG	p.A18V		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	18					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GTATCTCTGCGCCTTATCCCG	0.622													25	41					0	0	0	0	A	36700222	A	A	36700222	3	1	213	1	0	0	0	0	1	0	0	0	4308	1087	38	1	2204	1	DCLK1	13	36700222	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08		36700222	78469656	141	38828											
SPERT	220082	broad.mit.edu	37	chr13	46288501	46288501	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaccccaagaagcctagcagGgtctgaggcctcggccttgc	8	6	13	14	1	1	2	0	1	1	1	2	3	1	2	5	3	3	1	5	3	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr13:46288501G>T	uc001van.1	+	3	1421	c.1341G>T	c.(1339-1341)AGG>AGT	p.R447S	SPERT_uc001vao.2_Missense_Mutation_p.R411S	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	447						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		AGCCTAGCAGGGTCTGAGGCC	0.622													6	7					3.59834e-05	3.95817e-05	1	0	T	46288501	T	T	46288501	3	4	213	1	0	0	0	0	1	0	0	0	15105	1223	43	4	1351	4	SPERT	13	46288501	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	9588279	46288501	68881377	142	38829											
SLITRK5	26050	broad.mit.edu	37	chr13	88328994	88328994	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatctcgatgatccaggacCgcgctttcggggatctcacc	7	9	11	14	4	2	1	1	1	2	0	6	4	3	3	3	3	0	2	3	3	0	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr13:88328994C>A	uc001vln.2	+	2	1570	c.1351C>A	c.(1351-1353)CGC>AGC	p.R451S	SLITRK5_uc010tic.1_Missense_Mutation_p.R210S	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	451	Extracellular (Potential).|LRR 8.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GATCCAGGACCGCGCTTTCGG	0.597													35	21					9.65963e-10	1.20496e-09	1	0	A	88328994	A	A	88328994	3	1	213	1	0	0	0	0	1	0	0	0	14810	652	23	3	1353	3	SLITRK5	13	88328994	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	42040493	88328994	26840884	143	38830											
GPC5	2262	broad.mit.edu	37	chr13	92345880	92345880	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcagagccctcctgaagatGcaatactgcccgcactgcca	11	6	9	15	1	0	3	0	1	0	2	1	3	1	3	4	0	6	3	4	0	3	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr13:92345880G>C	uc010tif.1	+	3	1131	c.765G>C	c.(763-765)ATG>ATC	p.M255I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	255						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TCCTGAAGATGCAATACTGCC	0.552													30	25					0	0	0	0	C	92345880	C	C	92345880	3	2	213	1	0	0	0	0	1	0	0	0	6639	1319	46	4	775	4	GPC5	13	92345880	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	4016886	92345880	22823998	144	38831											
GPC5	2262	broad.mit.edu	37	chr13	93518663	93518663	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacattcactctgataagtGtggtgatgttacttcccggg	8	14	11	8	1	2	3	1	3	1	0	3	3	3	3	1	2	1	1	1	2	2	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr13:93518663G>C	uc010tif.1	+	8	2056	c.1690G>C	c.(1690-1692)GTG>CTG	p.V564L		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	564						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TCTGATAAGTGTGGTGATGTT	0.433													55	31					0	0	0	0	C	93518663	C	C	93518663	3	2	213	1	0	0	0	0	1	0	0	0	6639	1377	48	4	1720	4	GPC5	13	93518663	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	1172783	93518663	21651215	145	38832											
FAM155A	728215	broad.mit.edu	37	chr13	107822853	107822853	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgtccttccgttactcctCattggttgagttttcttcca	4	18	6	13	2	2	1	1	1	1	0	7	1	6	1	4	1	1	3	4	1	1	7			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr13:107822853C>A	uc001vql.2	-	3	1885	c.1369G>T	c.(1369-1371)GAG>TAG	p.E457*		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	457						integral to membrane	binding			skin(1)	1						CGTTACTCCTCATTGGTTGAG	0.522													31	19					2.61193e-14	3.63269e-14	1	0	A	107822853	A	A	107822853	4	1	213	1	0	0	0	0	0	1	0	0	5493	835	29	2	11	2	FAM155A	13	107822853	Nonsense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	14304190	107822853	7347025	146	38833											
NPAS3	64067	broad.mit.edu	37	chr14	34243588	34243588	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgagagtgtcgctgtccCacgggaggaccgtccccagc	6	6	14	15	3	0	1	0	1	0	1	3	4	2	3	5	2	1	1	5	2	0	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr14:34243588C>A	uc001wru.2	+	8	962	c.898C>A	c.(898-900)CAC>AAC	p.H300N	NPAS3_uc001wrs.2_Missense_Mutation_p.H287N|NPAS3_uc001wrt.2_Missense_Mutation_p.H268N|NPAS3_uc001wrv.2_Missense_Mutation_p.H270N	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GTCGCTGTCCCACGGGAGGAC	0.498													22	73					1.50039e-11	1.96267e-11	1	0	A	34243588	A	A	34243588	3	1	213	1	0	0	0	0	1	0	0	0	10618	594	21	4	983	4	NPAS3	14	34243588	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08		34243588	73105952	147	38834											
FSCB	84075	broad.mit.edu	37	chr14	44974135	44974135	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tataggagtctcctcagctgGtagagactgaacttcagcag	11	10	11	9	0	3	2	2	1	1	1	4	4	3	3	1	2	3	3	1	2	4	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr14:44974135G>A	uc001wvn.2	-	1	2365	c.2056C>T	c.(2056-2058)CCA>TCA	p.P686S		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	686						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TCCTCAGCTGGTAGAGACTGA	0.597													14	16					0	0	0	0	A	44974135	A	A	44974135	3	1	213	1	0	0	0	0	1	0	0	0	6100	1261	44	4	425	4	FSCB	14	44974135	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	10730547	44974135	62375405	148	38835											
TRIM9	114088	broad.mit.edu	37	chr14	51464789	51464789	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcagacgtttggaggaccaGggtcttgctgtacgggctga	7	10	15	9	2	2	2	1	1	1	1	2	4	2	4	1	4	2	4	1	4	1	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr14:51464789G>A	uc001wyx.3	-	7	2347	c.1582C>T	c.(1582-1584)CTG>TTG	p.L528L	TRIM9_uc001wyy.2_Silent_p.L524L|TRIM9_uc001wyz.3_Silent_p.L528L	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1	528	Fibronectin type-III.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					TGGAGGACCAGGGTCTTGCTG	0.552													13	42					0	0	0	0	A	51464789	A	A	51464789	2	1	213	1	0	0	0	0	0	0	0	1	16616	991	35	4		4	TRIM9	14	51464789	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	6490654	51464789	55884751	149	38836											
HIF1A	3091	broad.mit.edu	37	chr14	62204929	62204929	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattacccaccgctgaaacGccaaagccacttcgaagtag	13	6	7	15	3	0	1	0	1	0	0	1	2	0	1	5	0	3	2	5	0	5	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr14:62204929G>A	uc001xfq.2	+	10	1778	c.1374G>A	c.(1372-1374)ACG>ACA	p.T458T	HIF1A_uc001xfr.2_Silent_p.T458T|HIF1A_uc001xfs.2_Silent_p.T459T	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	458	ODD.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		CCGCTGAAACGCCAAAGCCAC	0.403													49	81					0	0	0	0	A	62204929	A	A	62204929	2	1	213	1	0	0	0	0	0	0	0	1	7142	1074	38	1		1	HIF1A	14	62204929	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	10740140	62204929	45144611	150	38837											
SIPA1L1	26037	broad.mit.edu	37	chr14	72175990	72175990	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatactctctccagcaatGcgtcaagtgcccatagtgat	11	10	8	12	1	2	1	1	1	1	0	4	1	3	1	2	0	4	2	2	0	5	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr14:72175990G>A	uc001xms.2	+	15	4228	c.3880G>A	c.(3880-3882)GCG>ACG	p.A1294T	SIPA1L1_uc001xmt.2_Missense_Mutation_p.A1273T|SIPA1L1_uc001xmu.2_Missense_Mutation_p.A1273T|SIPA1L1_uc001xmv.2_Missense_Mutation_p.A1294T|SIPA1L1_uc010ttm.1_Missense_Mutation_p.A748T|SIPA1L1_uc001xmw.2_Missense_Mutation_p.A59T	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1294	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CTCCAGCAATGCGTCAAGTGC	0.483													17	56					0	0	0	0	A	72175990	A	A	72175990	3	1	213	1	0	0	0	0	1	0	0	0	14394	1319	46	4	3934	4	SIPA1L1	14	72175990	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	9971061	72175990	35173550	151	38838											
C14orf4	64207	broad.mit.edu	37	chr14	77493792	77493794	+	In_Frame_Del	DEL	TGT	-	-																															gctgctgctgctgctgctgcTgttgctgctgctgctgctgc																								rs28718623		TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	3789df7b-2376-43c0-b181-5cd5ec3c5328	g.chr14:77493792_77493794delTGT	uc001xsy.2	-	1	1241_1243	c.342_344delACA	c.(340-345)CAACAG>CAG	p.114_115QQ>Q		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	114_115	Poly-Gln.|Potential.					nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		ctgctgctgctgttgctgctgct	0.266													---	---	---								-	77493794	-	-	77493792	7	5	213	1	0	1	0	1	0	0	0	0	1779	1580	55	0	2050	0	C14orf4	14	77493792	In_Frame_Del	DEL	TGT	TCGA-CV-6960-01A-41D-2012-08	5317802	77493792	29855748	152	38839											
EML5	161436	broad.mit.edu	37	chr14	89088975	89088975	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgcacacagaacgaacacaAtctgtggcttgtcctgtctc	10	10	8	13	1	2	1	0	0	2	1	4	2	3	1	1	1	3	2	1	1	3	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr14:89088975A>G	uc001xxg.2	-	37	5172	c.4986T>C	c.(4984-4986)GAT>GAC	p.D1662D	EML5_uc001xxf.2_Silent_p.D449D|EML5_uc001xxh.1_Silent_p.D793D|EML5_uc001xxd.2_5'Flank|EML5_uc001xxe.2_5'Flank	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1654						cytoplasm|microtubule				ovary(3)	3						AACGAACACAATCTGTGGCTT	0.473													23	55					0	0	0	0	G	89088975	G	G	89088975	2	3	213	1	0	0	0	0	0	0	0	1	5124	98	4	5		5	EML5	14	89088975	Silent	SNP	A	TCGA-CV-6960-01A-41D-2012-08	11595183	89088975	18260565	153	38840											
RIN3	79890	broad.mit.edu	37	chr14	93151468	93151468	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgccggcgtactctcaacaaGgcccgggcctcccgctcctc	5	6	10	20	5	1	0	1	0	1	0	5	0	3	0	5	3	2	2	5	3	3	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr14:93151468G>A	uc001yap.2	+	9	2756	c.2604G>A	c.(2602-2604)AAG>AAA	p.K868K	RIN3_uc010auk.2_Silent_p.K530K|RIN3_uc001yaq.2_Silent_p.K793K|RIN3_uc001yas.1_Silent_p.K530K	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	868					endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CTCTCAACAAGGCCCGGGCCT	0.662													10	33					0	0	0	0	A	93151468	A	A	93151468	2	1	213	1	0	0	0	0	0	0	0	1	13438	991	35	4		4	RIN3	14	93151468	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	4062493	93151468	14198072	154	38841											
SERPINA1	5265	broad.mit.edu	37	chr14	94845935	94845935	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatggacagtttgggtaaatGtaagctggcagacctgtcgt	11	11	13	6	1	0	1	0	0	0	1	1	2	0	2	1	3	1	5	1	3	4	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr14:94845935G>T	uc001ycx.3	-	4	1192	c.931C>A	c.(931-933)CAT>AAT	p.H311N	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Missense_Mutation_p.H311N|SERPINA1_uc010aux.2_Missense_Mutation_p.H311N|SERPINA1_uc001ycy.3_Missense_Mutation_p.H311N|SERPINA1_uc010auy.2_Missense_Mutation_p.H311N|SERPINA1_uc001ycz.3_Missense_Mutation_p.H311N|SERPINA1_uc010auz.2_Missense_Mutation_p.H311N|SERPINA1_uc010ava.2_Missense_Mutation_p.H311N|SERPINA1_uc001ydb.3_Missense_Mutation_p.H311N|SERPINA1_uc010avb.2_Missense_Mutation_p.H311N|SERPINA1_uc001ydc.3_Missense_Mutation_p.H311N|SERPINA1_uc001yda.1_Missense_Mutation_p.H311N	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	311					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	TTGGGTAAATGTAAGCTGGCA	0.493									Alpha-1-Antitrypsin_Deficiency				30	80					5.60225e-13	7.61654e-13	1	0	T	94845935	T	T	94845935	3	4	213	1	0	0	0	0	1	0	0	0	14151	1377	48	4	333	4	SERPINA1	14	94845935	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	1694467	94845935	12503605	155	38842											
SERPINA5	5104	broad.mit.edu	37	chr14	95054055	95054055	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagctccttcaggaactcaAccagcccagagatggcttcc	10	7	9	15	0	2	1	2	0	0	1	4	3	4	2	4	2	4	3	4	2	2	2	rs144727156	byFrequency	TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr14:95054055A>T	uc001ydm.2	+	3	566	c.356A>T	c.(355-357)AAC>ATC	p.N119I	SERPINA5_uc010ave.2_Missense_Mutation_p.N119I|SERPINA5_uc001ydn.1_Missense_Mutation_p.N119I	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	119					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CAGGAACTCAACCAGCCCAGA	0.567													11	22					0	0	0	0	T	95054055	T	T	95054055	3	4	213	1	0	0	0	0	1	0	0	0	14157	43	2	5	358	5	SERPINA5	14	95054055	Missense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	208120	95054055	12295485	156	38843											
APBA2	321	broad.mit.edu	37	chr15	29346999	29346999	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggcttcaagcccaagacCaggaccccagaagagaggct	14	3	12	12	0	1	4	1	0	0	4	1	6	1	5	4	3	1	2	4	3	3	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr15:29346999C>T	uc001zck.2	+	3	1119	c.912C>T	c.(910-912)ACC>ACT	p.T304T	APBA2_uc010azj.2_Silent_p.T304T|APBA2_uc010uat.1_Silent_p.T304T|APBA2_uc001zcl.2_Silent_p.T304T|APBA2_uc010uas.1_Silent_p.T304T	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	304					nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		AGCCCAAGACCAGGACCCCAG	0.677													5	24					0	0	0	0	T	29346999	T	T	29346999	2	4	213	1	0	0	0	0	0	0	0	1	757	581	21	4		4	APBA2	15	29346999	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08		29346999	73184393	157	38844											
VPS13C	54832	broad.mit.edu	37	chr15	62167104	62167104	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtccaaagaggcttctcactCcaatcactaacccctctgca	11	9	5	16	0	3	1	2	0	2	1	6	1	5	1	4	1	2	2	4	1	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr15:62167104C>A	uc002agz.2	-	77	10459	c.10385G>T	c.(10384-10386)GGA>GTA	p.G3462V	VPS13C_uc002aha.2_Missense_Mutation_p.G3419V|VPS13C_uc002ahb.1_Missense_Mutation_p.G3462V|VPS13C_uc002ahc.1_Missense_Mutation_p.G3419V	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3462					protein localization					ovary(2)	2						GCTTCTCACTCCAATCACTAA	0.299													13	18					1.96292e-10	2.4741e-10	1	0	A	62167104	A	A	62167104	3	1	213	1	0	0	0	0	1	0	0	0	17259	855	30	2	940	2	VPS13C	15	62167104	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	32820105	62167104	40364288	158	38845											
DCUN1D3	123879	broad.mit.edu	37	chr16	20873495	20873496	+	Missense_Mutation	DNP	GG	TT	TT																															agcagcactcgaaattctgtGgggtcaacacacaggtcatt																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr16:20873495_20873496GG>TT	uc002dhz.2	-	2	506_507	c.365_366CC>AA	c.(364-366)CCC>CAA	p.P122Q	ERI2_uc002dht.3_Intron	NM_173475	NP_775746	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain	122	DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				ovary(2)	2				GBM - Glioblastoma multiforme(48;0.249)		GAAATTCTGTGGGGTCAACACA	0.485													31	90					0	0	0	0	TT	20873496	TT	TT	20873495	3	4	213	1	0	0	0	0	1	0	0	0	4332	1335	47	4	556	4	DCUN1D3	16	20873495	Missense_Mutation	DNP	GG	TCGA-CV-6960-01A-41D-2012-08		20873495	69481258	159	38846											
N4BP1	9683	broad.mit.edu	37	chr16	48595684	48595684	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcgtatgcctttcttcAgaatcagaaaatctcctttt	9	18	4	10	1	5	2	2	0	3	2	7	2	5	2	2	0	1	1	2	0	4	7			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr16:48595684A>G	uc002efp.2	-	2	1107	c.870T>C	c.(868-870)TCT>TCC	p.S290S		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	290					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				GCCTTTCTTCAGAATCAGAAA	0.408													19	46					0	0	0	0	G	48595684	G	G	48595684	2	3	213	1	0	0	0	0	0	0	0	1	10162	175	7	5		5	N4BP1	16	48595684	Silent	SNP	A	TCGA-CV-6960-01A-41D-2012-08	27722189	48595684	41759069	160	38847											
CPNE2	221184	broad.mit.edu	37	chr16	57144698	57144698	+	Frame_Shift_Del	DEL	C	-	-																															tgccccagcagcgggggcagCccccatgggcccccagtatt																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr16:57144698delC	uc002eks.1	+	2	273	c.44delC	c.(43-45)GCCfs	p.A15fs	CPNE2_uc010cct.1_Frame_Shift_Del_p.A41fs|CPNE2_uc010ccu.1_Frame_Shift_Del_p.A15fs	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	15	C2 1.									central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				GCGGGGGCAGCCCCCATGGGC	0.642													---	---	---								-	57144698	-	-	57144698	7	5	213	1	0	1	0	1	0	0	0	0	3827	739	26	0	46	0	CPNE2	16	57144698	Frame_Shift_Del	DEL	C	TCGA-CV-6960-01A-41D-2012-08	8549014	57144698	33210055	161	38848											
SLC12A4	6560	broad.mit.edu	37	chr16	67984561	67984561	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcccagctcactcacttgtCccggagaaccacaccctcaa	10	6	7	18	1	3	1	3	0	0	1	4	2	4	1	4	2	2	1	4	2	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr16:67984561C>T	uc002euz.2	-	11	1591	c.1450G>A	c.(1450-1452)GAC>AAC	p.D484N	SLC12A4_uc010ceu.2_Missense_Mutation_p.D478N|SLC12A4_uc010vkh.1_Missense_Mutation_p.D453N|SLC12A4_uc010vki.1_Missense_Mutation_p.D484N|SLC12A4_uc010vkj.1_Missense_Mutation_p.D486N|SLC12A4_uc002eva.2_Missense_Mutation_p.D484N|SLC12A4_uc002evb.2_Intron	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	484	Cytoplasmic (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	ACTCACTTGTCCCGGAGAACC	0.632													3	15					0	0	0	0	T	67984561	T	T	67984561	3	4	213	1	0	0	0	0	1	0	0	0	14450	855	30	2	1863	2	SLC12A4	16	67984561	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	10839863	67984561	22370192	162	38849											
ATP2C2	9914	broad.mit.edu	37	chr16	84492912	84492912	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctcatcactctgtccacCgtgttcaacctgcccagccc	7	10	6	18	1	4	0	3	0	2	0	6	0	5	0	5	0	3	1	5	0	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr16:84492912C>T	uc002fhx.2	+	23	2342	c.2253C>T	c.(2251-2253)ACC>ACT	p.T751T	ATP2C2_uc010chj.2_Silent_p.T751T|ATP2C2_uc002fhy.2_Silent_p.T768T|ATP2C2_uc002fhz.2_Silent_p.T600T|ATP2C2_uc002fia.2_5'Flank	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	751	Helical; Name=6; (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						CTCTGTCCACCGTGTTCAACC	0.642													26	73					0	0	0	0	T	84492912	T	T	84492912	2	4	213	1	0	0	0	0	0	0	0	1	1146	639	23	1		1	ATP2C2	16	84492912	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	16508351	84492912	5861841	163	38850											
TP53	7157	broad.mit.edu	37	chr17	7577142	7577143	+	Nonsense_Mutation	DNP	CC	AA	AA																															cacctcaaagctgttccgtcCcagtagattaccactactca																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr17:7577142_7577143CC>AA	uc002gim.2	-	8	989_990	c.795_796GG>TT	c.(793-798)CTGGGA>CTTTGA	p.G266*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.G266*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.G134*|TP53_uc010cng.1_Nonsense_Mutation_p.G134*|TP53_uc002gii.1_Nonsense_Mutation_p.G134*|TP53_uc010cnh.1_Nonsense_Mutation_p.G266*|TP53_uc010cni.1_Nonsense_Mutation_p.G266*|TP53_uc002gij.2_Nonsense_Mutation_p.G266*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	266	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G266E(45)|p.G266R(42)|p.G266V(31)|p.G266*(12)|p.0?(7)|p.G266fs*79(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266G(2)|p.G262_S269delGNLLGRNS(2)|p.G266_E271delGRNSFE(2)|p.L265L(2)|p.G266T(1)|p.G266_N268delGRN(1)|p.E258fs*71(1)|p.G266fs*9(1)|p.G262fs*2(1)|p.L265_R267delLGR(1)|p.L265_K305del41(1)|p.G266fs*4(1)|p.L265P(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTGTTCCGTCCCAGTAGATTAC	0.52		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	13					0	0	0	0	AA	7577143	AA	AA	7577142	4	1	213	1	0	0	0	0	0	1	0	0	16448	632	22	4	490	4	TP53	17	7577142	Nonsense_Mutation	DNP	CC	TCGA-CV-6960-01A-41D-2012-08		7577142	73618068	164	38851											
ARHGEF15	22899	broad.mit.edu	37	chr17	8215500	8215500	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctccacaagaactaccccGaaactccaatgatgcaccaa	15	6	4	16	1	1	2	0	1	1	1	3	3	2	2	5	0	4	1	5	0	6	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr17:8215500G>A	uc002glc.2	+	2	264	c.143G>A	c.(142-144)CGA>CAA	p.R48Q	ARHGEF15_uc002glb.1_Missense_Mutation_p.R48Q|ARHGEF15_uc002gld.2_Missense_Mutation_p.R48Q|ARHGEF15_uc010vuw.1_Missense_Mutation_p.R48Q	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	48	Pro-rich.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GAACTACCCCGAAACTCCAAT	0.632													50	97					0	0	0	0	A	8215500	A	A	8215500	3	1	213	1	0	0	0	0	1	0	0	0	898	1058	37	1	145	1	ARHGEF15	17	8215500	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	638358	8215500	72979710	165	38852											
MYH1	4619	broad.mit.edu	37	chr17	10402040	10402040	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccttggacattgctctctGtagctcggccttggcttcct	3	14	11	13	1	1	0	0	0	1	0	4	1	2	1	3	4	2	4	3	4	1	5			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr17:10402040G>T	uc002gmo.2	-	30	4178	c.4084C>A	c.(4084-4086)CAG>AAG	p.Q1362K	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1362	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						ATTGCTCTCTGTAGCTCGGCC	0.592													41	85					4.14481e-20	6.23008e-20	1	0	T	10402040	T	T	10402040	3	4	213	1	0	0	0	0	1	0	0	0	10082	1386	48	4	1779	4	MYH1	17	10402040	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	2186540	10402040	70793170	166	38853											
MYO15A	51168	broad.mit.edu	37	chr17	18067125	18067125	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccctgaggccttcaatgaaTatgttatcttcgttgtcacc	8	14	8	11	1	3	2	2	2	1	0	4	2	3	2	3	1	0	2	3	1	4	5			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr17:18067125T>A	uc010vxh.1	+	59	10098	c.9760T>A	c.(9760-9762)TAT>AAT	p.Y3254N	MYO15A_uc010vxi.1_Missense_Mutation_p.Y518N|MYO15A_uc010vxk.1_5'UTR|MYO15A_uc010vxl.1_Missense_Mutation_p.Y243N|MYO15A_uc002gsl.2_Missense_Mutation_p.Y261N|MYO15A_uc010vxm.1_Missense_Mutation_p.Y176N|MYO15A_uc002gsm.1_Missense_Mutation_p.Y176N|MYO15A_uc010cpv.2_RNA	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3254	Tail.|FERM.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CTTCAATGAATATGTTATCTT	0.463													7	17					0	0	0	0	A	18067125	A	A	18067125	3	1	213	1	0	0	0	0	1	0	0	0	10116	1406	49	5	9990	5	MYO15A	17	18067125	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	7665085	18067125	63128085	167	38854											
PSMD11	5717	broad.mit.edu	37	chr17	30801833	30801833	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcttgcacttcggtatgcAgggaggcaggtagggactcc	9	8	15	9	1	0	0	0	0	0	0	2	2	1	2	1	5	3	6	1	5	3	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr17:30801833A>G	uc010cta.1	+	8	880	c.840A>G	c.(838-840)GCA>GCG	p.A280A	PSMD11_uc010wbz.1_Silent_p.A280A|PSMD11_uc002hhm.2_Silent_p.A280A	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	280	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			TTCGGTATGCAGGGAGGCAGG	0.488													3	47					0	0	0	0	G	30801833	G	G	30801833	2	3	213	1	0	0	0	0	0	0	0	1	12756	175	7	5		5	PSMD11	17	30801833	Silent	SNP	A	TCGA-CV-6960-01A-41D-2012-08	12734708	30801833	50393377	168	38855											
IMP5	162540	broad.mit.edu	37	chr17	43922823	43922823	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccccagagcccatcatcgActacaacatgctggtcatct	11	8	6	16	1	3	1	2	0	1	1	4	2	3	1	3	1	4	1	3	1	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr17:43922823A>T	uc010wka.1	+	1	551	c.551A>T	c.(550-552)GAC>GTC	p.D184V	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	184	Extracellular (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		CCCATCATCGACTACAACATG	0.637													37	86					0	0	0	0	T	43922823	T	T	43922823	3	4	213	1	0	0	0	0	1	0	0	0	7760	275	10	5	553	5	IMP5	17	43922823	Missense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	13120990	43922823	37272387	169	38856											
MED13	9969	broad.mit.edu	37	chr17	60028197	60028197	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcaataccttaagaaaaaGgggacactgatattgtgctt	14	11	10	6	0	0	2	0	1	0	1	0	3	0	3	1	3	2	2	1	3	6	5			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr17:60028197G>T	uc002izo.2	-	28	6357	c.6280C>A	c.(6280-6282)CTT>ATT	p.L2094I		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2094					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TTAAGAAAAAGGGGACACTGA	0.413													4	72					0.00024832	0.000267082	1	0	T	60028197	T	T	60028197	3	4	213	1	0	0	0	0	1	0	0	0	9483	1000	35	4	256	4	MED13	17	60028197	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	16105374	60028197	21167013	170	38857											
TAF4B	6875	broad.mit.edu	37	chr18	23873435	23873435	+	Missense_Mutation	SNP	C	T	T																															gcctggaaataaaattctgtCacttcaagcatctcctactc																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr18:23873435C>T	uc002kvu.3	+	9	2261	c.1772C>T	c.(1771-1773)TCA>TTA	p.S591L	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.S596L	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	591					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			AAAATTCTGTCACTTCAAGCA	0.289													9	13					0	0	0	0	T	23873435	T	T	23873435	3	4	213	1	0	0	0	0	1	0	0	0	15593	838	29	2	1806	2	TAF4B	18	23873435	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08		23873435	54203813	171	38858	73	2									
TAF4B	6875	broad.mit.edu	37	chr18	23873440	23873440	+	Nonsense_Mutation	SNP	C	T	T																															gaaataaaattctgtcacttCaagcatctcctactcagaaa																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr18:23873440C>T	uc002kvu.3	+	9	2266	c.1777C>T	c.(1777-1779)CAA>TAA	p.Q593*	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Nonsense_Mutation_p.Q598*	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	593					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			TCTGTCACTTCAAGCATCTCC	0.284													10	14					0	0	0	0	T	23873440	T	T	23873440	4	4	213	1	0	0	0	0	0	1	0	0	15593	827	29	2	1811	2	TAF4B	18	23873440	Nonsense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	5	23873440	54203808	172	38859	73	2									
CDH19	28513	broad.mit.edu	37	chr18	64172320	64172320	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccaacttgcaaagactgcCtgtataggctcctgatctca	10	10	9	12	0	1	2	1	1	1	1	3	2	2	2	3	2	3	3	3	2	4	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr18:64172320C>G	uc002lkc.1	-	12	2186	c.2048G>C	c.(2047-2049)AGG>ACG	p.R683T	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	683	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CAAAGACTGCCTGTATAGGCT	0.483													47	56					0	0	0	0	G	64172320	G	G	64172320	3	3	213	1	0	0	0	0	1	0	0	0	3119	681	24	4	274	4	CDH19	18	64172320	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	40298880	64172320	13904928	173	38860											
MARCH2	51257	broad.mit.edu	37	chr19	8486776	8486776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctccctgtgtgactgctccGgcagccctgccttctccaag	4	10	10	17	1	1	1	0	1	1	0	4	1	3	1	5	1	3	3	5	1	1	1	rs141281179		TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr19:8486776G>A	uc002mjv.2	+	3	493	c.52G>A	c.(52-54)GGC>AGC	p.G18S	MARCH2_uc002mjw.2_Missense_Mutation_p.G18S|MARCH2_uc002mjx.2_Missense_Mutation_p.G18S	NM_016496	NP_057580	Q9P0N8	MARH2_HUMAN	membrane-associated ring finger (C3HC4) 2	18					endocytosis	cytoplasmic vesicle|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TGACTGCTCCGGCAGCCCTGC	0.677													22	67					0	0	0	0	A	8486776	A	A	8486776	3	1	213	1	0	0	0	0	1	0	0	0	9354	1116	39	1	54	1	MARCH2	19	8486776	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08		8486776	50642207	174	38861											
OR7G2	390882	broad.mit.edu	37	chr19	9213869	9213869	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagttccggatcctctatCagtcccaggagaaggaattt	10	11	10	10	1	2	1	1	0	1	1	5	4	5	3	3	3	1	2	3	3	3	3	rs141362700		TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr19:9213869C>T	uc010xkk.1	-	1	114	c.114G>A	c.(112-114)CTG>CTA	p.L38L		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GATCCTCTATCAGTCCCAGGA	0.458													20	42					0	0	0	0	T	9213869	T	T	9213869	2	4	213	1	0	0	0	0	0	0	0	1	11277	813	29	2		2	OR7G2	19	9213869	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	727093	9213869	49915114	175	38862											
RGL3	57139	broad.mit.edu	37	chr19	11510580	11510580	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggccgggggactgccagcaGgagcatctctgcttctagga	8	7	15	11	1	2	0	0	0	2	0	3	3	2	3	2	5	4	3	2	5	1	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr19:11510580G>T	uc002mrp.2	-	16	1761	c.1697C>A	c.(1696-1698)CCT>CAT	p.P566H	RGL3_uc002mrn.2_Missense_Mutation_p.P330H|RGL3_uc002mrm.2_Missense_Mutation_p.P330H|RGL3_uc002mro.2_Missense_Mutation_p.P572H	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	566	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						ACTGCCAGCAGGAGCATCTCT	0.667													22	37					7.41877e-09	9.06739e-09	1	0	T	11510580	T	T	11510580	3	4	213	1	0	0	0	0	1	0	0	0	13343	1000	35	4	451	4	RGL3	19	11510580	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	2296711	11510580	47618403	176	38863											
CPAMD8	27151	broad.mit.edu	37	chr19	17056421	17056428	+	Frame_Shift_Del	DEL	TCTCCTCA	-	-																															gaccctcctgtcggcgtgatTctcctcagggtgtttgctgg																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr19:17056421_17056428delTCTCCTCA	uc002nfb.2	-	22	2897_2904	c.2865_2872delTGAGGAGA	c.(2863-2874)CCTGAGGAGAATfs	p.P955fs		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	908_911						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TCGGCGTGATTCTCCTCAGGGTGTTTGC	0.572													---	---	---								-	17056428	-	-	17056421	7	5	213	1	0	1	0	1	0	0	0	0	3810	1783	62	0	3010	0	CPAMD8	19	17056421	Frame_Shift_Del	DEL	TCTCCTCA	TCGA-CV-6960-01A-41D-2012-08	5545841	17056421	42072562	177	38864											
TMEM59L	25789	broad.mit.edu	37	chr19	18729276	18729276	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctccaccctggtgaccGcgcctggccagcacctcaag	6	6	11	18	2	1	1	1	1	0	0	2	1	2	1	6	2	2	3	6	2	1	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr19:18729276G>C	uc002njy.3	+	7	961	c.874G>C	c.(874-876)GCG>CCG	p.A292P		NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	292						Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						CCTGGTGACCGCGCCTGGCCA	0.667													3	14					0	0	0	0	C	18729276	C	C	18729276	3	2	213	1	0	0	0	0	1	0	0	0	16252	1087	38	3	900	3	TMEM59L	19	18729276	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	1672855	18729276	40399707	178	38865											
APLP1	333	broad.mit.edu	37	chr19	36362583	36362583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtggctcggatcggttcCgtggtgtggagtatgtgtgc	3	13	17	8	3	0	0	0	0	0	0	3	2	1	2	2	5	1	3	2	5	1	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr19:36362583C>T	uc002oce.2	+	5	745	c.607C>T	c.(607-609)CGT>TGT	p.R203C	APLP1_uc010xsz.1_Missense_Mutation_p.R164C|APLP1_uc002ocf.2_Missense_Mutation_p.R203C|APLP1_uc002ocg.2_Missense_Mutation_p.R106C|APLP1_uc010xta.1_Missense_Mutation_p.R197C	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	203	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGATCGGTTCCGTGGTGTGGA	0.637													23	26					0	0	0	0	T	36362583	T	T	36362583	3	4	213	1	0	0	0	0	1	0	0	0	778	652	23	1	625	1	APLP1	19	36362583	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	17633307	36362583	22766400	179	38866											
SIGLEC12	89858	broad.mit.edu	37	chr19	52000164	52000164	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcccctgacagcgtttgcGtcctccatgcctgtatcccc	5	10	9	17	2	0	1	0	1	0	0	3	2	3	1	7	0	4	2	7	0	1	2	rs145034575		TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr19:52000164G>T	uc002pwx.1	-	7	1625	c.1569C>A	c.(1567-1569)GAC>GAA	p.D523E	SIGLEC12_uc002pww.1_Missense_Mutation_p.D405E|SIGLEC12_uc010eoy.1_Missense_Mutation_p.D250E	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	523	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CAGCGTTTGCGTCCTCCATGC	0.577													27	34					3.65163e-15	5.10806e-15	1	0	T	52000164	T	T	52000164	3	4	213	1	0	0	0	0	1	0	0	0	14373	1136	40	3	226	3	SIGLEC12	19	52000164	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	15637581	52000164	7128819	180	38867											
DPRX	503834	broad.mit.edu	37	chr19	54135364	54135364	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacatctggattagaagatgCcaggctcagaggatcttcgt	11	10	11	9	1	3	3	1	0	2	3	4	5	3	5	1	3	1	1	1	3	2	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr19:54135364C>A	uc002qcf.1	+	1	55	c.4C>A	c.(4-6)CCA>ACA	p.P2T		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	2						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		TTAGAAGATGCCAGGCTCAGA	0.498													36	49					1.07637e-12	1.44711e-12	1	0	A	54135364	A	A	54135364	3	1	213	1	0	0	0	0	1	0	0	0	4760	739	26	4	6	4	DPRX	19	54135364	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	2135200	54135364	4993619	181	38868											
SIGLEC1	6614	broad.mit.edu	37	chr20	3679898	3679898	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccactggcactgtggccGtcccgggcccggcagtggta	4	6	17	14	3	0	0	0	0	0	0	1	0	1	0	4	6	0	3	4	6	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr20:3679898G>C	uc002wja.2	-	7	1737	c.1737C>G	c.(1735-1737)GAC>GAG	p.D579E	SIGLEC1_uc002wiz.3_Missense_Mutation_p.D579E	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	579	Ig-like C2-type 5.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CACTGTGGCCGTCCCGGGCCC	0.692													7	15					0	0	0	0	C	3679898	C	C	3679898	3	2	213	1	0	0	0	0	1	0	0	0	14370	1136	40	3	3452	3	SIGLEC1	20	3679898	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08		3679898	59345622	182	38869											
MAVS	57506	broad.mit.edu	37	chr20	3845384	3845384	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcctactagcatggtgctCaccaaggtgtctgccagcac	8	9	11	13	0	2	0	1	0	1	0	2	0	2	0	3	2	6	3	3	2	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr20:3845384C>T	uc002wjw.3	+	6	1276	c.1107C>T	c.(1105-1107)CTC>CTT	p.L369L	MAVS_uc002wjx.3_Silent_p.L228L|MAVS_uc002wjy.3_Silent_p.L67L	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	369	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						GCATGGTGCTCACCAAGGTGT	0.592													25	63					0	0	0	0	T	3845384	T	T	3845384	2	4	213	1	0	0	0	0	0	0	0	1	9391	813	29	2		2	MAVS	20	3845384	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	165486	3845384	59180136	183	38870											
C20orf4	25980	broad.mit.edu	37	chr20	34828211	34828211	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcactcaccaacttcatcAgcgaagccacagtggagaag	13	7	8	13	1	4	1	4	0	1	1	5	3	4	1	2	1	3	0	2	1	3	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr20:34828211A>T	uc002xfc.1	+	2	514	c.421A>T	c.(421-423)AGC>TGC	p.S141C	C20orf4_uc002xfd.1_Missense_Mutation_p.S141C|C20orf4_uc002xfe.1_Missense_Mutation_p.S141C	NM_015511	NP_056326	Q9Y312	CT004_HUMAN	hypothetical protein LOC25980	141											0	Breast(12;0.0162)	Myeloproliferative disorder(115;0.0393)				CAACTTCATCAGCGAAGCCAC	0.567													78	81					0	0	0	0	T	34828211	T	T	34828211	3	4	213	1	0	0	0	0	1	0	0	0	2121	188	7	5	423	5	C20orf4	20	34828211	Missense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	30982827	34828211	28197309	184	38871											
PTPN1	5770	broad.mit.edu	37	chr20	49196356	49196356	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgggaaatgcagggagttCttcccaaatcaccagtgggt	12	9	12	8	0	2	0	1	0	1	0	3	2	3	2	2	3	1	2	2	3	3	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr20:49196356C>G	uc002xvl.2	+	8	1155	c.981C>G	c.(979-981)TTC>TTG	p.F327L	PTPN1_uc010zys.1_Missense_Mutation_p.F254L	NM_002827	NP_002818	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type	327					blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding				0		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	GCAGGGAGTTCTTCCCAAATC	0.572											OREG0026029	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	125					0	0	0	0	G	49196356	G	G	49196356	3	3	213	1	0	0	0	0	1	0	0	0	12842	912	32	2	1011	2	PTPN1	20	49196356	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	14368145	49196356	13829164	185	38872											
LIPI	149998	broad.mit.edu	37	chr21	15561702	15561702	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctctgaaggaatcctttaCacttagctgagagaattcaa	14	12	7	8	0	2	3	1	2	1	1	4	5	3	4	1	1	2	1	1	1	6	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr21:15561702C>A	uc002yjm.2	-	2	158	c.148G>T	c.(148-150)GTA>TTA	p.V50L	LIPI_uc010gkw.1_5'UTR	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	29					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		GAATCCTTTACACTTAGCTGA	0.358													22	36					1.22574e-08	1.4906e-08	1	0	A	15561702	A	A	15561702	3	1	213	1	0	0	0	0	1	0	0	0	8867	478	17	4	1333	4	LIPI	21	15561702	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08		15561702	32568193	186	38873											
NCAM2	4685	broad.mit.edu	37	chr21	22696776	22696776	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaagaaatgacattttcCtgcagggcctcaggctctcc	10	9	11	11	0	2	3	1	1	1	2	4	4	3	3	3	3	1	2	3	3	2	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr21:22696776C>T	uc002yld.1	+	6	942	c.693C>T	c.(691-693)TCC>TCT	p.S231S	NCAM2_uc011acb.1_Silent_p.S89S|NCAM2_uc011acc.1_Silent_p.S256S	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	231	Ig-like C2-type 3.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TGACATTTTCCTGCAGGGCCT	0.493													17	56					0	0	0	0	T	22696776	T	T	22696776	2	4	213	1	0	0	0	0	0	0	0	1	10257	668	24	4		4	NCAM2	21	22696776	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	7135074	22696776	25433119	187	38874											
KRTAP11-1	337880	broad.mit.edu	37	chr21	32253791	32253791	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggccactggaacaatgcagCgtcctccaatgggcctggaa	10	6	13	12	1	0	0	0	0	0	0	2	2	2	2	4	4	3	1	4	4	4	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr21:32253791C>A	uc002yov.2	-	1	84	c.53G>T	c.(52-54)CGC>CTC	p.R18L		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	18						keratin filament	structural molecule activity			pancreas(1)	1						AACAATGCAGCGTCCTCCAAT	0.547													34	59					2.48696e-23	3.76152e-23	1	0	A	32253791	A	A	32253791	3	1	213	1	0	0	0	0	1	0	0	0	8556	768	27	3	442	3	KRTAP11-1	21	32253791	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	9557015	32253791	15876104	188	38875											
FTCD	10841	broad.mit.edu	37	chr21	47570433	47570433	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgaactttcttcagacGtcctggctgcaaaggaagag	10	9	11	11	1	2	3	1	1	1	2	3	4	3	4	2	2	2	2	2	2	3	2	rs149667449	byFrequency	TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr21:47570433G>C	uc002zif.2	-	6	687	c.643C>G	c.(643-645)CGT>GGT	p.R215G	FTCD_uc002zig.2_Missense_Mutation_p.R215G|FTCD_uc002zih.2_Missense_Mutation_p.R215G|FTCD_uc010gqf.2_Missense_Mutation_p.R215G|FTCD_uc010gqg.1_Missense_Mutation_p.R84G	NM_006657	NP_006648	O95954	FTCD_HUMAN	formiminotransferase cyclodeaminase	215	Formiminotransferase C-subdomain (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			pancreas(1)|skin(1)	2	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	TTCTTCAGACGTCCTGGCTGC	0.577													16	46					0	0	0	0	C	47570433	C	C	47570433	3	2	213	1	0	0	0	0	1	0	0	0	6115	1145	40	3	1018	3	FTCD	21	47570433	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	15316642	47570433	559462	189	38876											
CDC45	8318	broad.mit.edu	37	chr22	19504093	19504093	+	Frame_Shift_Del	DEL	C	-	-																															gctgcccctggtgatggctgCccccctgagcatggagcatg																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr22:19504093delC	uc002zpr.2	+	16	1560	c.1484delC	c.(1483-1485)GCCfs	p.A495fs	CDC45_uc011aha.1_Frame_Shift_Del_p.A527fs|CDC45_uc002zps.2_Frame_Shift_Del_p.A495fs|CDC45_uc002zpt.2_Frame_Shift_Del_p.A449fs	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	495					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						GTGATGGCTGCCCCCCTGAGC	0.627													---	---	---								-	19504093	-	-	19504093	7	5	213	1	0	1	0	1	0	0	0	0	3096	739	26	0	1646	0	CDC45	22	19504093	Frame_Shift_Del	DEL	C	TCGA-CV-6960-01A-41D-2012-08		19504093	31800473	190	38877											
THAP7	80764	broad.mit.edu	37	chr22	21354710	21354710	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atggagttgtgggccctcggCcctcggagcagctggtaagg	6	8	17	10	2	0	0	0	0	0	0	2	2	0	2	2	6	2	4	2	6	1	2			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr22:21354710C>T	uc002ztr.1	-	5	419	c.389G>A	c.(388-390)GGC>GAC	p.G130D	THAP7_uc002zts.1_Missense_Mutation_p.G130D|FLJ39582_uc002ztt.1_5'Flank|FLJ39582_uc002ztu.1_5'Flank|FLJ39582_uc002ztv.2_5'Flank	NM_001008695	NP_001008695	Q9BT49	THAP7_HUMAN	THAP domain containing 7 isoform 2	130					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding				0	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GGGCCCTCGGCCCTCGGAGCA	0.622													3	8					0	0	0	0	T	21354710	T	T	21354710	3	4	213	1	0	0	0	0	1	0	0	0	15915	739	26	4	544	4	THAP7	22	21354710	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	1850617	21354710	29949856	191	38878											
CABIN1	23523	broad.mit.edu	37	chr22	24515613	24515613	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagccgcttcccccagcactAtaagagtctctaccgtctgg	8	9	9	15	2	2	1	0	0	2	1	4	2	3	1	4	1	3	2	4	1	3	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr22:24515613A>G	uc002zzi.1	+	28	4707	c.4580A>G	c.(4579-4581)TAT>TGT	p.Y1527C	CABIN1_uc002zzj.1_Missense_Mutation_p.Y1448C|CABIN1_uc002zzl.1_Missense_Mutation_p.Y1527C	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1527					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CCCCAGCACTATAAGAGTCTC	0.647													80	141					0	0	0	0	G	24515613	G	G	24515613	3	3	213	1	0	0	0	0	1	0	0	0	2540	449	16	5	4686	5	CABIN1	22	24515613	Missense_Mutation	SNP	A	TCGA-CV-6960-01A-41D-2012-08	3160903	24515613	26788953	192	38879											
ASPHD2	57168	broad.mit.edu	37	chr22	26838460	26838460	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atggctgtgagctggtggtgGggggagagccccagtgctgg	5	8	21	7	0	0	2	0	1	0	1	0	3	0	2	2	7	3	3	2	7	0	0			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr22:26838460G>C	uc003acg.2	+	3	1319	c.922G>C	c.(922-924)GGG>CGG	p.G308R		NM_020437	NP_065170	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	308	Lumenal (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			ovary(1)	1						GCTGGTGGTGGGGGGAGAGCC	0.552													51	140					0	0	0	0	C	26838460	C	C	26838460	3	2	213	1	0	0	0	0	1	0	0	0	1057	1232	43	4	928	4	ASPHD2	22	26838460	Missense_Mutation	SNP	G	TCGA-CV-6960-01A-41D-2012-08	2322847	26838460	24466106	193	38880											
LARGE	9215	broad.mit.edu	37	chr22	33733754	33733754	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccacatgcttgttcttcaCccggagcttcttgggggagt	5	13	11	12	1	3	0	1	0	2	0	4	2	4	2	2	3	2	3	2	3	0	5			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr22:33733754C>A	uc003and.3	-	11	1744	c.1165G>T	c.(1165-1167)GTG>TTG	p.V389L	LARGE_uc011amd.1_Missense_Mutation_p.V188L|LARGE_uc003ane.3_Missense_Mutation_p.V389L|LARGE_uc010gwp.2_Intron|LARGE_uc011ame.1_Missense_Mutation_p.V321L|LARGE_uc011amf.1_Missense_Mutation_p.V389L|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	389	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				TTGTTCTTCACCCGGAGCTTC	0.557													11	27					0.000151284	0.000163441	1	0	A	33733754	A	A	33733754	3	1	213	1	0	0	0	0	1	0	0	0	8667	507	18	4	1129	4	LARGE	22	33733754	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	6895294	33733754	17570812	194	38881											
MYH9	4627	broad.mit.edu	37	chr22	36689419	36689419	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttctccaggttgtgcttggCctcctcctcctcctccagct	2	14	7	18	0	1	0	0	0	1	0	7	0	6	0	7	2	2	3	7	2	0	3			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr22:36689419C>G	uc003apg.2	-	30	4282	c.4051G>C	c.(4051-4053)GCC>CCC	p.A1351P		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1351	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TTGTGCTTGGCCTCCTCCTCC	0.652			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				31	56					0	0	0	0	G	36689419	G	G	36689419	3	3	213	1	0	0	0	0	1	0	0	0	10095	739	26	4	1879	4	MYH9	22	36689419	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	2955665	36689419	14615147	195	38882											
SHANK3	85358	broad.mit.edu	37	chr22	51159933	51159933	+	Frame_Shift_Del	DEL	G	-	-																															gggcaggagcccagcaggctGgggggggccgaagaggagcg																										TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chr22:51159933delG	uc003bne.1	+	22	3720	c.3720delG	c.(3718-3720)CTGfs	p.L1240fs	SHANK3_uc003bnf.1_Frame_Shift_Del_p.L687fs|SHANK3_uc010hbg.1_Frame_Shift_Del_p.L422fs	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1240										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CCAGCAGGCTGGGGGGGGCCG	0.721													---	---	---								-	51159933	-	-	51159933	7	5	213	1	0	1	0	1	0	0	0	0	14331	1335	47	0	3806	0	SHANK3	22	51159933	Frame_Shift_Del	DEL	G	TCGA-CV-6960-01A-41D-2012-08	14470514	51159933	144633	196	38883											
BRWD3	254065	broad.mit.edu	37	chrX	79999656	79999656	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagagtgttttcatagttaaCagccatgtcagaaatttcag	14	13	8	6	0	3	2	3	0	0	2	3	2	3	2	1	0	2	2	1	0	4	5			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chrX:79999656C>A	uc004edt.2	-	8	951	c.688G>T	c.(688-690)GTT>TTT	p.V230F	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_Missense_Mutation_p.V59F|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_5'UTR|BRWD3_uc004edr.2_5'UTR|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_5'UTR|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_5'UTR|BRWD3_uc004eea.2_5'UTR|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	230	WD 3.									ovary(4)	4						TCATAGTTAACAGCCATGTCA	0.448													23	17					6.36457e-07	7.33441e-07	1	0	A	79999656	A	A	79999656	3	1	213	1	0	0	0	0	1	0	0	0	1531	478	17	4	4856	4	BRWD3	23	79999656	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08		79999656	75270904	197	38884											
POU3F4	5456	broad.mit.edu	37	chrX	82764275	82764275	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcctcgctggcagacagcCtccagttggagaaggaagtg	9	8	13	11	1	1	2	0	0	1	2	4	4	2	3	3	3	1	3	3	3	2	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chrX:82764275C>T	uc004eeg.2	+	1	1007	c.943C>T	c.(943-945)CTC>TTC	p.L315F		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	315	Homeobox.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCAGACAGCCTCCAGTTGGA	0.557													11	9					0	0	0	0	T	82764275	T	T	82764275	3	4	213	1	0	0	0	0	1	0	0	0	12332	681	24	4	945	4	POU3F4	23	82764275	Missense_Mutation	SNP	C	TCGA-CV-6960-01A-41D-2012-08	2764619	82764275	72506285	198	38885											
DCX	1641	broad.mit.edu	37	chrX	110653366	110653366	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtcagacagagatcgcgtCaggtcagccagcaaggcgtc	10	7	13	11	3	3	2	3	0	0	2	5	3	3	2	1	2	2	1	1	2	1	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chrX:110653366C>G	uc004epd.2	-	2	676	c.504G>C	c.(502-504)CTG>CTC	p.L168L	DCX_uc011msv.1_Silent_p.L168L|DCX_uc004epe.2_Silent_p.L87L|DCX_uc004epf.2_Silent_p.L87L|DCX_uc004epg.2_Silent_p.L87L	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	168	Doublecortin 1.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						GAGATCGCGTCAGGTCAGCCA	0.527													51	27					0	0	0	0	G	110653366	G	G	110653366	2	3	213	1	0	0	0	0	0	0	0	1	4335	813	29	2		2	DCX	23	110653366	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	27889091	110653366	44617194	199	38886											
FAM70A	55026	broad.mit.edu	37	chrX	119410744	119410744	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaattctttccttaccatgTccttaaagcctccaaggaca	11	13	4	13	0	2	0	1	0	1	0	5	1	5	1	5	1	2	0	5	1	5	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chrX:119410744T>C	uc004eso.3	-	8	970	c.743A>G	c.(742-744)GAC>GGC	p.D248G	FAM70A_uc004esp.3_Missense_Mutation_p.D224G|FAM70A_uc010nqo.2_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	248						integral to membrane				lung(1)|breast(1)	2						CCTTACCATGTCCTTAAAGCC	0.507													26	10					0	0	0	0	C	119410744	C	C	119410744	3	2	213	1	0	0	0	0	1	0	0	0	5637	1667	58	5	318	5	FAM70A	23	119410744	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	8757378	119410744	35859816	200	38887											
ODZ1	10178	broad.mit.edu	37	chrX	123515059	123515059	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcaaggcaccgtccatcaTtgtatcggggagtcataggt	9	11	11	10	2	3	0	3	0	0	0	5	1	4	1	2	4	0	2	2	4	3	4			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chrX:123515059T>C	uc004euj.2	-	31	7569	c.7505A>G	c.(7504-7506)AAT>AGT	p.N2502S	ODZ1_uc011muj.1_Missense_Mutation_p.N2508S|ODZ1_uc010nqy.2_Missense_Mutation_p.N2509S	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2502	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CCGTCCATCATTGTATCGGGG	0.463													60	32					0	0	0	0	C	123515059	C	C	123515059	3	2	213	1	0	0	0	0	1	0	0	0	10888	1493	52	5	676	5	ODZ1	23	123515059	Missense_Mutation	SNP	T	TCGA-CV-6960-01A-41D-2012-08	4104315	123515059	31755501	201	38888											
ATP11C	286410	broad.mit.edu	37	chrX	138899028	138899028	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aataagaaatttacctgcttGatggctgtaacagttataac	15	13	7	6	0	0	2	0	1	0	1	0	2	0	2	1	1	4	4	1	1	7	7			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chrX:138899028G>A	uc004faz.2	-	4	420	c.321C>T	c.(319-321)ATC>ATT	p.I107I	ATP11C_uc004fba.2_Silent_p.I107I	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	107	Helical; (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TTACCTGCTTGATGGCTGTAA	0.368													17	21					0	0	0	0	A	138899028	A	A	138899028	2	1	213	1	0	0	0	0	0	0	0	1	1123	1280	45	2		2	ATP11C	23	138899028	Silent	SNP	G	TCGA-CV-6960-01A-41D-2012-08	15383969	138899028	16371532	202	38889											
SPANXN1	494118	broad.mit.edu	37	chrX	144329127	144329127	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggaacagcccacttcaagCatcaatggggagaagaggaa	16	5	12	8	0	2	2	2	0	0	2	2	5	2	4	1	4	3	1	1	4	5	1			TCGA-CV-6960-01A-41D-2012-08	TCGA-CV-6960-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	750da72e-cabd-4b97-8160-8c4e39272b8b	007618bc-1555-4b26-80ba-94678bcefcc8	g.chrX:144329127C>T	uc004fcb.2	+	1	21	c.21C>T	c.(19-21)AGC>AGT	p.S7S		NM_001009614	NP_001009614	Q5VSR9	SPXN1_HUMAN	SPANX-N1 protein	7											0	Acute lymphoblastic leukemia(192;6.56e-05)					CCACTTCAAGCATCAATGGGG	0.363													46	41					0	0	0	0	T	144329127	T	T	144329127	2	4	213	1	0	0	0	0	0	0	0	1	15056	709	25	4		4	SPANXN1	23	144329127	Silent	SNP	C	TCGA-CV-6960-01A-41D-2012-08	5430099	144329127	10941433	203	38890											
C1orf159	54991	broad.mit.edu	37	chr1	1019467	1019467	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttcctgcagaccccacgtCtcgggaacaggaaagagcat	11	7	10	13	2	1	2	0	0	1	2	3	4	2	4	3	2	3	2	3	2	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:1019467C>T	uc001act.2	-	11	1362	c.876G>A	c.(874-876)GAG>GAA	p.E292E	C1orf159_uc001acu.2_Intron|C1orf159_uc001acr.2_Splice_Site|C1orf159_uc001acs.2_Splice_Site|C1orf159_uc010nyd.1_Splice_Site|C1orf159_uc001acm.2_Intron|C1orf159_uc009vju.1_Intron|C1orf159_uc001acn.2_Silent_p.E256E|C1orf159_uc001acp.2_Intron	NM_017891	NP_060361	Q96HA4	CA159_HUMAN	hypothetical protein LOC54991	292						integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GACCCCACGTCTCGGGAACAG	0.647													3	23					0	0	0	0	T	1019467	T	T	1019467	2	4	214	1	0	0	0	0	0	0	0	1	2017	928	32	2		2	C1orf159	1	1019467	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08		1019467	248231154	1	38891											
TAS1R3	83756	broad.mit.edu	37	chr1	1268701	1268701	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtgcgccgggtcaaggggttCcactcctgctgctacgactg	5	9	14	13	3	1	0	1	0	0	0	3	1	3	0	3	3	4	3	3	3	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:1268701C>G	uc010nyk.1	+	5	1542	c.1542C>G	c.(1540-1542)TTC>TTG	p.F514L		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	514	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	TCAAGGGGTTCCACTCCTGCT	0.711													4	8					0	0	0	0	G	1268701	G	G	1268701	3	3	214	1	0	0	0	0	1	0	0	0	15630	854	30	2	1560	2	TAS1R3	1	1268701	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	249234	1268701	247981920	2	38892											
PLCH2	9651	broad.mit.edu	37	chr1	2428128	2428128	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaagtccgtggccacccacGacatagagatggagggtgag	11	5	14	11	2	0	2	0	1	0	1	1	5	1	3	4	3	0	0	4	3	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:2428128G>A	uc001aji.1	+	14	2192	c.1918G>A	c.(1918-1920)GAC>AAC	p.D640N	PLCH2_uc010nyz.1_Missense_Mutation_p.D428N|PLCH2_uc009vle.1_Missense_Mutation_p.D428N|PLCH2_uc001ajj.1_Missense_Mutation_p.D428N|PLCH2_uc001ajk.1_Missense_Mutation_p.D428N|PLCH2_uc001ajl.1_5'Flank	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	640	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GGCCACCCACGACATAGAGAT	0.682													4	14					0	0	0	0	A	2428128	A	A	2428128	3	1	214	1	0	0	0	0	1	0	0	0	12093	1058	37	1	1972	1	PLCH2	1	2428128	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1159427	2428128	246822493	3	38893											
KIAA0562	9731	broad.mit.edu	37	chr1	3756183	3756183	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcaataccttttgcaaatCagcaatggcttgttttagtt	11	15	8	7	0	1	0	1	0	0	0	1	0	1	0	1	2	3	6	1	2	5	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:3756183C>G	uc001aky.2	-	7	1083	c.724G>C	c.(724-726)GAT>CAT	p.D242H	KIAA0562_uc010nzm.1_RNA|KIAA0562_uc001akz.2_Missense_Mutation_p.D242H	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	242	Potential.					centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		TTTTGCAAATCAGCAATGGCT	0.348													14	89					0	0	0	0	G	3756183	G	G	3756183	3	3	214	1	0	0	0	0	1	0	0	0	8223	826	29	2	2117	2	KIAA0562	1	3756183	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1328055	3756183	245494438	4	38894											
PRAMEF2	65122	broad.mit.edu	37	chr1	12918895	12918895	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aggccccaccgagactactgGagctggcggggcagagcctg	8	4	16	13	2	0	2	0	0	0	2	0	4	0	3	4	5	3	2	4	5	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:12918895G>C	uc001aum.1	+	2	118	c.31G>C	c.(31-33)GAG>CAG	p.E11Q		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	11											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAGACTACTGGAGCTGGCGGG	0.557													35	148					0	0	0	0	C	12918895	C	C	12918895	3	2	214	1	0	0	0	0	1	0	0	0	12495	1175	41	2	33	2	PRAMEF2	1	12918895	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9162712	12918895	236331726	5	38895											
DDI2	84301	broad.mit.edu	37	chr1	15983119	15983119	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaattcacacagagcgtcaGaagccatgatgcatgtagtg	13	9	10	9	1	2	3	2	1	0	2	2	3	2	3	1	0	3	2	1	0	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:15983119G>A	uc001awx.1	+	9	1287	c.1191G>A	c.(1189-1191)CAG>CAA	p.Q397Q	DDI2_uc009voj.1_Silent_p.Q138Q	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	397					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CAGAGCGTCAGAAGCCATGAT	0.458													39	93					0	0	0	0	A	15983119	A	A	15983119	2	1	214	1	0	0	0	0	0	0	0	1	4346	933	33	2		2	DDI2	1	15983119	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3064224	15983119	233267502	6	38896											
C1orf89	79363	broad.mit.edu	37	chr1	16563180	16563180	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agccaggtactccttgccctCggcactctcgtgccagtttg	5	11	10	15	2	1	0	0	0	1	0	4	0	2	0	4	2	4	3	4	2	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:16563180C>T	uc001ayd.2	-	1	480	c.58G>A	c.(58-60)GAG>AAG	p.E20K		NM_030907	NP_112169	Q9BU20	RSG1_HUMAN	hypothetical protein LOC79363	20					cellular protein localization|cilium assembly|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|small GTPase mediated signal transduction	cilium|microtubule basal body	GTP binding				0		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.2e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;9.12e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTTGCCCTCGGCACTCTCG	0.632													3	5					0	0	0	0	T	16563180	T	T	16563180	3	4	214	1	0	0	0	0	1	0	0	0	2076	893	31	1	738	1	C1orf89	1	16563180	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	580061	16563180	232687441	7	38897											
RCC2	55920	broad.mit.edu	37	chr1	17749292	17749292	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtctaggggcttctactctCttggtgtcaccatgtcccag	6	13	10	12	0	4	0	1	0	3	0	6	0	5	0	2	3	1	1	2	3	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:17749292C>G	uc001bal.2	-	4	611	c.564G>C	c.(562-564)AAG>AAC	p.K188N	RCC2_uc001bam.2_Missense_Mutation_p.K188N	NM_001136204	NP_001129676	Q9P258	RCC2_HUMAN	regulator of chromosome condensation 2	188	RCC1 2.				cell division|mitotic prometaphase	chromosome, centromeric region|cytosol|microtubule|nucleolus|spindle					0		Colorectal(325;0.000147)|Breast(348;0.00122)|Renal(390;0.00145)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;7.69e-06)|COAD - Colon adenocarcinoma(227;1.19e-05)|Kidney(64;0.000189)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.0135)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)		CTTCTACTCTCTTGGTGTCAC	0.557													21	68					0	0	0	0	G	17749292	G	G	17749292	3	3	214	1	0	0	0	0	1	0	0	0	13239	912	32	2	1040	2	RCC2	1	17749292	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1186112	17749292	231501329	8	38898											
IGSF21	84966	broad.mit.edu	37	chr1	18703351	18703351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggttgggagccgcctcctgGacggcagcgctgagttcgac	5	7	17	12	4	0	1	0	1	0	0	2	4	1	3	3	4	2	4	3	4	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:18703351G>A	uc001bau.1	+	8	1542	c.1159G>A	c.(1159-1161)GAC>AAC	p.D387N	IGSF21_uc001bav.1_Missense_Mutation_p.D208N	NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	387	Ig-like 2.					extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CCGCCTCCTGGACGGCAGCGC	0.657													20	43					0	0	0	0	A	18703351	A	A	18703351	3	1	214	1	0	0	0	0	1	0	0	0	7638	1174	41	2	1189	2	IGSF21	1	18703351	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	954059	18703351	230547270	9	38899											
AKR7L	246181	broad.mit.edu	37	chr1	19597298	19597298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccaccggggcgctgtggtCaggtgcatgtagatagaaga	9	9	15	8	2	1	3	1	0	0	3	2	3	2	3	2	4	1	3	2	4	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:19597298C>T	uc010ocx.1	-	3	346	c.346G>A	c.(346-348)GAC>AAC	p.D116N	AKR7L_uc010ocy.1_Missense_Mutation_p.D116N	NM_201252	NP_957704			aflatoxin B1 aldehyde reductase 3 isoform 1												0						GCGCTGTGGTCAGGTGCATGT	0.622													11	31					0	0	0	0	T	19597298	T	T	19597298	3	4	214	1	0	0	0	0	1	0	0	0	477	826	29	2	673	2	AKR7L	1	19597298	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	893947	19597298	229653323	10	38900											
AHDC1	27245	broad.mit.edu	37	chr1	27876393	27876393	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaacagagtcccattcttcCgggaccgtctcttgcgcttt	6	12	10	13	3	2	1	0	0	2	1	5	3	4	3	3	2	2	1	3	2	1	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:27876393C>T	uc009vsy.2	-	6	3203	c.2234G>A	c.(2233-2235)CGG>CAG	p.R745Q	AHDC1_uc009vsz.1_Missense_Mutation_p.R745Q	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	745	Gly-rich.						DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CCCATTCTTCCGGGACCGTCT	0.677													10	43					0	0	0	0	T	27876393	T	T	27876393	3	4	214	1	0	0	0	0	1	0	0	0	412	652	23	1	2581	1	AHDC1	1	27876393	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	8279095	27876393	221374228	11	38901											
OSCP1	127700	broad.mit.edu	37	chr1	36883811	36883811	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttggctgctccgtgatctCaaactcccccatgattcgag	7	11	8	15	2	1	2	1	2	1	0	5	3	3	2	4	1	2	2	4	1	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:36883811C>G	uc001cap.2	-	11	1181	c.1099G>C	c.(1099-1101)GAG>CAG	p.E367Q	OSCP1_uc001caq.2_Missense_Mutation_p.E357Q	NM_145047	NP_659484	Q8WVF1	OSCP1_HUMAN	oxidored-nitro domain-containing protein isoform	367					transport	basal plasma membrane				ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCCGTGATCTCAAACTCCCCC	0.577													7	36					0	0	0	0	G	36883811	G	G	36883811	3	3	214	1	0	0	0	0	1	0	0	0	11340	835	29	2	74	2	OSCP1	1	36883811	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	9007418	36883811	212366810	12	38902											
RIMKLA	284716	broad.mit.edu	37	chr1	42880305	42880305	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgaggcaaatgctaatgttgGcttcctagcctttgaccagg	9	12	11	9	0	0	2	0	2	0	0	1	2	1	2	3	3	2	4	3	3	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:42880305G>C	uc001chi.2	+	5	974	c.836G>C	c.(835-837)GGC>GCC	p.G279A		NM_173642	NP_775913	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family	279	ATP-grasp.				protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						GCTAATGTTGGCTTCCTAGCC	0.483													23	270					0	0	0	0	C	42880305	C	C	42880305	3	2	214	1	0	0	0	0	1	0	0	0	13430	1203	42	4	854	4	RIMKLA	1	42880305	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5996494	42880305	206370316	13	38903											
SLC2A1	6513	broad.mit.edu	37	chr1	43394969	43394969	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccttctcgaagatgctcGtggagtaatagaagacctgc	10	9	11	11	3	1	3	0	0	1	3	3	5	1	4	3	1	2	2	3	1	4	3	rs80359823		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:43394969G>C	uc001cik.2	-	7	1409	c.884C>G	c.(883-885)ACG>AGG	p.T295R		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	295	Extracellular (Potential).		T -> M (in GLUT1DS1; 75% of wild-type glucose uptake activity).		carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	GAAGATGCTCGTGGAGTAATA	0.572													7	9					0	0	0	0	C	43394969	C	C	43394969	3	2	214	1	0	0	0	0	1	0	0	0	14602	1145	40	3	610	3	SLC2A1	1	43394969	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	514664	43394969	205855652	14	38904											
MPL	4352	broad.mit.edu	37	chr1	43812513	43812513	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagatctccagtgggcatCtggaattggagtggcagcac	9	8	16	8	0	2	1	0	0	2	1	3	4	2	3	1	5	1	3	1	5	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:43812513C>G	uc001ciw.2	+	8	1261	c.1216C>G	c.(1216-1218)CTG>GTG	p.L406V	MPL_uc001civ.2_Missense_Mutation_p.L406V|MPL_uc009vwr.2_Missense_Mutation_p.L399V	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	406	Fibronectin type-III 2.|Extracellular (Potential).				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CAGTGGGCATCTGGAATTGGA	0.567			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						17	80					0	0	0	0	G	43812513	G	G	43812513	3	3	214	1	0	0	0	0	1	0	0	0	9783	912	32	2	1246	2	MPL	1	43812513	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	417544	43812513	205438108	15	38905											
KIAA0467	23334	broad.mit.edu	37	chr1	43907767	43907767	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catctgctgcttctgggaagGaacttcttgcagtggaggag	8	11	14	8	0	3	0	0	0	3	0	3	4	3	4	0	4	4	3	0	4	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:43907767G>A	uc001cjk.1	+	41	5604	c.5142G>A	c.(5140-5142)AGG>AGA	p.R1714R		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2613						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTCTGGGAAGGAACTTCTTGC	0.527													4	46					0	0	0	0	A	43907767	A	A	43907767	2	1	214	1	0	0	0	0	0	0	0	1	8217	1165	41	2		2	KIAA0467	1	43907767	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	95254	43907767	205342854	16	38906											
TMEM53	79639	broad.mit.edu	37	chr1	45120816	45120816	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccaaaacacgaagtgaaggGatacccagtgactcggagaa	16	4	12	9	2	0	3	0	2	0	1	1	6	0	4	2	2	2	0	2	2	6	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:45120816G>T	uc001cmc.2	-	3	285	c.249C>A	c.(247-249)ATC>ATA	p.I83I	TMEM53_uc001cmb.1_Intron|TMEM53_uc001cmd.2_Silent_p.I10I|TMEM53_uc009vxh.1_Intron|TMEM53_uc010ola.1_Intron	NM_024587	NP_078863	Q6P2H8	TMM53_HUMAN	transmembrane protein 53	83						integral to membrane				ovary(2)	2	Acute lymphoblastic leukemia(166;0.155)					GAAGTGAAGGGATACCCAGTG	0.552											OREG0013446	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	47					4.68919e-08	4.97434e-08	1	0	T	45120816	T	T	45120816	2	4	214	1	0	0	0	0	0	0	0	1	16245	1164	41	2		2	TMEM53	1	45120816	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1213049	45120816	204129805	17	38907											
PTCH2	8643	broad.mit.edu	37	chr1	45295679	45295679	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagccatggcagcccccactCagctcgtgagccacattggg	9	6	11	15	1	1	1	1	1	0	0	2	1	1	1	4	2	4	2	4	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:45295679C>G	uc010olf.1	-	7	849	c.837G>C	c.(835-837)CTG>CTC	p.L279L	PTCH2_uc010olg.1_5'UTR	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	279	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					AGCCCCCACTCAGCTCGTGAG	0.607									Basal_Cell_Nevus_syndrome				10	42					0	0	0	0	G	45295679	G	G	45295679	2	3	214	1	0	0	0	0	0	0	0	1	12793	813	29	2		2	PTCH2	1	45295679	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	174863	45295679	203954942	18	38908											
LRRC41	10489	broad.mit.edu	37	chr1	46745255	46745255	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaattgggctgggcgcttCtcaaacagacggcagaagga	13	6	14	8	2	1	3	1	0	1	3	2	4	1	4	0	4	1	3	0	4	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:46745255C>T	uc001cpn.2	-	8	2096	c.2052G>A	c.(2050-2052)GAG>GAA	p.E684E	LRRC41_uc010omb.1_Silent_p.E684E	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	684										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					CTGGGCGCTTCTCAAACAGAC	0.552													45	132					0	0	0	0	T	46745255	T	T	46745255	2	4	214	1	0	0	0	0	0	0	0	1	9049	912	32	2		2	LRRC41	1	46745255	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1449576	46745255	202505366	19	38909											
MKNK1	8569	broad.mit.edu	37	chr1	47046281	47046281	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccctctccaagcaattcaGaggtcagcttgtacatatct	10	12	6	13	0	4	1	2	0	2	1	6	1	5	1	2	1	3	3	2	1	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:47046281G>A	uc001cqb.2	-	4	399	c.155C>T	c.(154-156)TCT>TTT	p.S52F	MKNK1_uc010omd.1_5'UTR|MKNK1_uc001cqc.2_Missense_Mutation_p.S52F|MKNK1_uc009vyi.2_Missense_Mutation_p.S52F|MKNK1_uc010ome.1_5'UTR|MKNK1_uc009vyj.2_Intron|MKNK1_uc001cqd.2_Missense_Mutation_p.S40F|MKNK1_uc010omf.1_Missense_Mutation_p.S52F	NM_003684	NP_003675	Q9BUB5	MKNK1_HUMAN	MAP kinase-interacting serine/threonine kinase 1	52	Protein kinase.				intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2	Acute lymphoblastic leukemia(166;0.155)					AAGCAATTCAGAGGTCAGCTT	0.478													22	41					0	0	0	0	A	47046281	A	A	47046281	3	1	214	1	0	0	0	0	1	0	0	0	9657	942	33	2	1286	2	MKNK1	1	47046281	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	301026	47046281	202204340	20	38910											
OSBPL9	114883	broad.mit.edu	37	chr1	52246990	52246990	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcattggacattaccaaatGatactgaagagaacacagtg	16	9	9	7	0	1	3	1	2	0	1	1	5	1	4	1	1	3	0	1	1	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:52246990G>A	uc001cst.2	+	16	1430	c.1411G>A	c.(1411-1413)GAT>AAT	p.D471N	OSBPL9_uc001css.2_Missense_Mutation_p.D476N|OSBPL9_uc001csx.2_RNA|OSBPL9_uc009vza.2_Missense_Mutation_p.D472N|OSBPL9_uc001csu.2_Missense_Mutation_p.D481N|OSBPL9_uc001csv.2_Missense_Mutation_p.D306N|OSBPL9_uc001csw.2_Missense_Mutation_p.D458N|OSBPL9_uc001csy.2_Missense_Mutation_p.D293N|OSBPL9_uc001csz.2_Missense_Mutation_p.D293N|OSBPL9_uc001cta.2_Missense_Mutation_p.D361N|OSBPL9_uc001ctb.2_Missense_Mutation_p.D256N	NM_024586	NP_078862	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9 isoform e	471					lipid transport		lipid binding			central_nervous_system(1)	1						ATTACCAAATGATACTGAAGA	0.358													12	22					0	0	0	0	A	52246990	A	A	52246990	3	1	214	1	0	0	0	0	1	0	0	0	11338	1290	45	2	1577	2	OSBPL9	1	52246990	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5200709	52246990	197003631	21	38911											
DMRTB1	63948	broad.mit.edu	37	chr1	53925595	53925595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccgtggcgatgcccagcCttgcgggacccccttttggg	3	8	14	16	4	0	0	0	0	0	0	0	2	0	1	6	3	3	0	6	3	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ea8183de-8f9b-4d30-a23b-c6ffc183f22b	g.chr1:53925595C>T	uc001cvq.1	+	1	524	c.469C>T	c.(469-471)CTT>TTT	p.L157F		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	157	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GATGCCCAGCCTTGCGGGACC	0.761													5	9					0	0	0	0	T	53925595	T	T	53925595	3	4	214	1	0	0	0	0	1	0	0	0	4612	681	24	4	471	4	DMRTB1	1	53925595	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1678605	53925595	195325026	22	38912											
FAM151A	338094	broad.mit.edu	37	chr1	55081832	55081832	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acattgacgtcagcctccagGactgtgatgttgcctgtgga	8	11	12	10	1	1	2	1	2	0	0	2	4	2	4	3	2	2	1	3	2	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:55081832G>T	uc001cxn.2	-	3	408	c.276C>A	c.(274-276)GTC>GTA	p.V92V	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	92						integral to membrane					0						CAGCCTCCAGGACTGTGATGT	0.408													29	69					1.74807e-11	1.88235e-11	1	0	T	55081832	T	T	55081832	2	4	214	1	0	0	0	0	0	0	0	1	5486	1161	41	2		2	FAM151A	1	55081832	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1156237	55081832	194168789	23	38913											
FGGY	55277	broad.mit.edu	37	chr1	59844477	59844477	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctttgatctcccggacttCttatcgtggaaggcaacagg	8	13	10	10	2	3	1	0	1	3	0	5	3	3	3	1	4	1	1	1	4	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:59844477C>G	uc001czi.3	+	5	734	c.522C>G	c.(520-522)TTC>TTG	p.F174L	FGGY_uc001czg.2_Missense_Mutation_p.F62L|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Missense_Mutation_p.F174L|FGGY_uc001czj.3_Missense_Mutation_p.F174L|FGGY_uc001czk.3_Missense_Mutation_p.F62L|FGGY_uc001czl.3_Missense_Mutation_p.F86L	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	174					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					TCCCGGACTTCTTATCGTGGA	0.393													3	47					0	0	0	0	G	59844477	G	G	59844477	3	3	214	1	0	0	0	0	1	0	0	0	5903	912	32	2	536	2	FGGY	1	59844477	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4762645	59844477	189406144	24	38914											
DNTTIP2	30836	broad.mit.edu	37	chr1	94337703	94337703	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatgctggctctcatcttCagtgctttgagatcattttt	6	18	7	10	0	4	1	3	1	2	1	6	2	5	1	1	1	2	3	1	1	0	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:94337703C>T	uc001dqf.2	-	5	2030	c.1992G>A	c.(1990-1992)CTG>CTA	p.L664L	DNTTIP2_uc010otm.1_RNA	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	664					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		CTCTCATCTTCAGTGCTTTGA	0.403													72	151					0	0	0	0	T	94337703	T	T	94337703	2	4	214	1	0	0	0	0	0	0	0	1	4704	813	29	2		2	DNTTIP2	1	94337703	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	34493226	94337703	154912918	25	38915											
AGL	178	broad.mit.edu	37	chr1	100346890	100346890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggttttacactaagtggaatCctgaagcattgccttcaaac	12	12	8	9	0	1	1	1	1	0	0	2	2	2	2	2	2	4	2	2	2	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:100346890C>T	uc001dsi.1	+	16	2444	c.2044C>T	c.(2044-2046)CCT>TCT	p.P682S	AGL_uc001dsj.1_Missense_Mutation_p.P682S|AGL_uc001dsk.1_Missense_Mutation_p.P682S|AGL_uc001dsl.1_Missense_Mutation_p.P682S|AGL_uc001dsm.1_Missense_Mutation_p.P666S|AGL_uc001dsn.1_Missense_Mutation_p.P665S	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	682	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TAAGTGGAATCCTGAAGCATT	0.373													19	58					0	0	0	0	T	100346890	T	T	100346890	3	4	214	1	0	0	0	0	1	0	0	0	384	855	30	2	2171	2	AGL	1	100346890	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	6009187	100346890	148903731	26	38916											
AGL	178	broad.mit.edu	37	chr1	100366244	100366244	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcatggtctcattcctaatCtactgggtgaaggaatttat	10	14	10	7	0	2	1	1	1	2	0	4	2	3	2	1	4	1	1	1	4	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:100366244C>G	uc001dsi.1	+	26	3815	c.3415C>G	c.(3415-3417)CTA>GTA	p.L1139V	AGL_uc001dsj.1_Missense_Mutation_p.L1139V|AGL_uc001dsk.1_Missense_Mutation_p.L1139V|AGL_uc001dsl.1_Missense_Mutation_p.L1139V|AGL_uc001dsm.1_Missense_Mutation_p.L1123V|AGL_uc001dsn.1_Missense_Mutation_p.L1122V	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1139	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CATTCCTAATCTACTGGGTGA	0.398													37	151					0	0	0	0	G	100366244	G	G	100366244	3	3	214	1	0	0	0	0	1	0	0	0	384	912	32	2	3582	2	AGL	1	100366244	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	19354	100366244	148884377	27	38917											
C1orf59	113802	broad.mit.edu	37	chr1	109191450	109191450	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcatgggacaggggcctttGagccaccaatgtctttgggc	8	9	14	10	0	1	1	0	1	1	0	1	2	1	2	3	4	2	1	3	4	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:109191450G>C	uc001dvt.3	-	8	1158	c.920C>G	c.(919-921)TCA>TGA	p.S307*	C1orf59_uc001dvu.3_Nonsense_Mutation_p.S307*|C1orf59_uc009wer.2_3'UTR	NM_001102592	NP_001096062	Q5T8I9	HENMT_HUMAN	hypothetical protein LOC113802	307					gene silencing by RNA|piRNA metabolic process	P granule	metal ion binding|O-methyltransferase activity|RNA binding|RNA methyltransferase activity				0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0152)|Lung(183;0.0895)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.163)		AGGGGCCTTTGAGCCACCAAT	0.517													9	56					0	0	0	0	C	109191450	C	C	109191450	4	2	214	1	0	0	0	0	0	1	0	0	2061	1294	45	2	265	2	C1orf59	1	109191450	Nonsense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	8825206	109191450	140059171	28	38918											
GPSM2	29899	broad.mit.edu	37	chr1	109461321	109461321	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctactctttgtcaacagactGaaggggaaaaaatacaaaac	18	8	7	8	0	2	2	1	1	1	1	2	3	2	3	0	2	4	0	0	2	9	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:109461321G>A	uc010ovc.1	+	12	1846	c.1350G>A	c.(1348-1350)CTG>CTA	p.L450L	AKNAD1_uc010ovb.1_Intron|GPSM2_uc010ovd.1_Silent_p.L450L|GPSM2_uc010ove.1_Silent_p.L450L	NM_013296	NP_037428	P81274	GPSM2_HUMAN	LGN protein	450					G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		TCAACAGACTGAAGGGGAAAA	0.373													9	56					0	0	0	0	A	109461321	A	A	109461321	2	1	214	1	0	0	0	0	0	0	0	1	6774	1277	45	2		2	GPSM2	1	109461321	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	269871	109461321	139789300	29	38919											
CELSR2	1952	broad.mit.edu	37	chr1	109795615	109795615	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccctgaggtctttcagctgGacatcttctccggggagctg	5	12	12	12	1	4	1	1	1	3	0	6	3	5	3	2	4	2	2	2	4	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:109795615G>A	uc001dxa.3	+	1	2975	c.2914G>A	c.(2914-2916)GAC>AAC	p.D972N		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	972	Extracellular (Potential).|Cadherin 8.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTTTCAGCTGGACATCTTCTC	0.592													28	76					0	0	0	0	A	109795615	A	A	109795615	3	1	214	1	0	0	0	0	1	0	0	0	3237	1174	41	2	2916	2	CELSR2	1	109795615	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	334294	109795615	139455006	30	38920											
SLC22A15	55356	broad.mit.edu	37	chr1	116577934	116577934	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccctctctgtatctacttGattaaccaaaaatggtgagt	12	14	6	9	0	2	2	0	2	2	0	3	2	2	2	2	1	3	1	2	1	6	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:116577934G>A	uc001egb.3	+	7	1201	c.1071G>A	c.(1069-1071)TTG>TTA	p.L357L		NM_018420	NP_060890	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	357	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			large_intestine(2)	2	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GTATCTACTTGATTAACCAAA	0.438													12	28					0	0	0	0	A	116577934	A	A	116577934	2	1	214	1	0	0	0	0	0	0	0	1	14511	1281	45	2		2	SLC22A15	1	116577934	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6782319	116577934	132672687	31	38921											
WDR3	10885	broad.mit.edu	37	chr1	118483837	118483837	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgacaagacaggcaggattCttgcttgccatgtgagtacc	10	10	11	10	1	1	2	0	1	1	1	2	4	1	3	2	2	3	3	2	2	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:118483837C>G	uc010oxe.1	+	8	946	c.880C>G	c.(880-882)CTT>GTT	p.L294V	WDR3_uc001ehi.2_Intron|WDR3_uc001ehh.2_Missense_Mutation_p.L123V	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	294	WD 6.					nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		AGGCAGGATTCTTGCTTGCCA	0.413													5	55					0	0	0	0	G	118483837	G	G	118483837	3	3	214	1	0	0	0	0	1	0	0	0	17353	913	32	2	906	2	WDR3	1	118483837	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1905903	118483837	130766784	32	38922											
NBPF10	100132406	broad.mit.edu	37	chr1	145368591	145368591	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatttgaggaacagcacatCagcttcgccctttacgtgga	10	11	9	11	2	2	1	2	1	0	0	3	3	2	3	1	2	4	2	1	2	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:145368591C>T	uc001end.3	+	86	10829	c.10794C>T	c.(10792-10794)ATC>ATT	p.I3598I	NBPF9_uc010oye.1_Silent_p.I882I|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Silent_p.I451I|NBPF10_uc010oyk.1_Silent_p.I239I|NBPF10_uc010oyl.1_Silent_p.I239I	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3523											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AACAGCACATCAGCTTCGCCC	0.448													56	466					0	0	0	0	T	145368591	T	T	145368591	2	4	214	1	0	0	0	0	0	0	0	1	10246	816	29	2		2	NBPF10	1	145368591	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	26884754	145368591	103882030	33	38923											
CHD1L	9557	broad.mit.edu	37	chr1	146756150	146756150	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaagctagtcaagagggccGatcactccgaaataaaggca	16	5	11	9	2	2	1	2	0	0	1	3	4	3	1	2	2	1	2	2	2	6	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:146756150G>A	uc001epm.3	+	16	1895	c.1832G>A	c.(1831-1833)CGA>CAA	p.R611Q	uc001epp.2_Intron|CHD1L_uc001epn.3_Missense_Mutation_p.R498Q|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Missense_Mutation_p.R517Q|CHD1L_uc010ozp.1_Missense_Mutation_p.R330Q|CHD1L_uc001epo.3_Missense_Mutation_p.R407Q|CHD1L_uc010ozq.1_Missense_Mutation_p.R184Q|CHD1L_uc009wji.2_Missense_Mutation_p.R330Q	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	611					chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					CAAGAGGGCCGATCACTCCGA	0.348													17	63					0	0	0	0	A	146756150	A	A	146756150	3	1	214	1	0	0	0	0	1	0	0	0	3339	1058	37	1	1894	1	CHD1L	1	146756150	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1387559	146756150	102494471	34	38924											
MCL1	4170	broad.mit.edu	37	chr1	150551469	150551469	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggtaccgagagataatctCcagcgactgccggtacaact	13	7	10	11	3	1	1	0	0	1	1	2	4	1	1	3	2	5	2	3	2	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:150551469C>T	uc001euz.2	-	1	668	c.538G>A	c.(538-540)GAG>AAG	p.E180K	MCL1_uc010pch.1_Missense_Mutation_p.E70K|MCL1_uc001eva.2_Missense_Mutation_p.E180K	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	180					anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GAGATAATCTCCAGCGACTGC	0.627													25	59					0	0	0	0	T	150551469	T	T	150551469	3	4	214	1	0	0	0	0	1	0	0	0	9437	864	30	2	537	2	MCL1	1	150551469	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3795319	150551469	98699152	35	38925											
FLG	2312	broad.mit.edu	37	chr1	152282333	152282333	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggatccatgtctttctcctgGacttgaccttgcctgttcct	4	16	8	13	0	2	1	0	1	2	0	5	3	4	3	5	2	1	1	5	2	0	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:152282333G>C	uc001ezu.1	-	3	5065	c.5029C>G	c.(5029-5031)CCA>GCA	p.P1677A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1677	Ser-rich.|Filaggrin 10.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTTCTCCTGGACTTGACCTT	0.567									Ichthyosis				129	468					0	0	0	0	C	152282333	C	C	152282333	3	2	214	1	0	0	0	0	1	0	0	0	5954	1174	41	2	7160	2	FLG	1	152282333	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1730864	152282333	96968288	36	38926											
FLG	2312	broad.mit.edu	37	chr1	152283709	152283709	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttgtccttacgagtttgtCtgcttgcacttctggatcct	4	18	9	10	1	2	0	0	0	2	0	4	2	4	1	2	1	3	4	2	1	1	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:152283709C>G	uc001ezu.1	-	3	3689	c.3653G>C	c.(3652-3654)AGA>ACA	p.R1218T	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1218	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACGAGTTTGTCTGCTTGCACT	0.552									Ichthyosis				126	378					0	0	0	0	G	152283709	G	G	152283709	3	3	214	1	0	0	0	0	1	0	0	0	5954	913	32	2	8536	2	FLG	1	152283709	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1376	152283709	96966912	37	38927											
FLG	2312	broad.mit.edu	37	chr1	152283989	152283989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgggcagactcagactgttCatgagtgctcacctggtaga	10	10	12	9	0	3	4	3	1	0	3	3	4	3	4	1	2	1	4	1	2	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:152283989C>T	uc001ezu.1	-	3	3409	c.3373G>A	c.(3373-3375)GAA>AAA	p.E1125K	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1125	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCAGACTGTTCATGAGTGCTC	0.607									Ichthyosis				124	299					0	0	0	0	T	152283989	T	T	152283989	3	4	214	1	0	0	0	0	1	0	0	0	5954	835	29	2	8816	2	FLG	1	152283989	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	280	152283989	96966632	38	38928											
FLG2	388698	broad.mit.edu	37	chr1	152323370	152323370	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtatctcctgtctgtccatGagtagtttccagtctcccat	6	15	8	12	0	3	1	0	1	3	0	7	1	5	1	4	1	0	3	4	1	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:152323370G>A	uc001ezw.3	-	3	6965	c.6892C>T	c.(6892-6894)CAT>TAT	p.H2298Y	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2298							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCTGTCCATGAGTAGTTTCC	0.483													25	313					0	0	0	0	A	152323370	A	A	152323370	3	1	214	1	0	0	0	0	1	0	0	0	5955	1290	45	2	287	2	FLG2	1	152323370	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	39381	152323370	96927251	39	38929											
KPRP	448834	broad.mit.edu	37	chr1	152732722	152732722	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctacagcagctgtttccctCagtatcggtcccggacttca	7	11	8	15	2	2	0	2	0	0	0	5	1	4	1	3	2	3	4	3	2	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:152732722C>T	uc001fal.1	+	2	716	c.658C>T	c.(658-660)CAG>TAG	p.Q220*		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	220						cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTTTCCCTCAGTATCGGTC	0.577													9	138					0	0	0	0	T	152732722	T	T	152732722	4	4	214	1	0	0	0	0	0	1	0	0	8475	827	29	2	660	2	KPRP	1	152732722	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	409352	152732722	96517899	40	38930											
S100A16	140576	broad.mit.edu	37	chr1	153580541	153580541	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcttgctgatcttgttcttGaccaggctgtacttagacac	7	15	8	11	0	3	3	0	2	3	1	3	3	3	3	1	1	2	4	1	1	2	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:153580541G>C	uc001fcc.2	-	2	220	c.87C>G	c.(85-87)GTC>GTG	p.V29V	S100A16_uc001fcd.1_Silent_p.V29V	NM_080388	NP_525127	Q96FQ6	S10AG_HUMAN	S100 calcium binding protein A16	29	1; low affinity (Potential).|EF-hand 1.					cytosol|nucleolus	calcium ion binding|protein homodimerization activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCTTGTTCTTGACCAGGCTGT	0.532													13	46					0	0	0	0	C	153580541	C	C	153580541	2	2	214	1	0	0	0	0	0	0	0	1	13842	1277	45	2		2	S100A16	1	153580541	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	847819	153580541	95670080	41	38931											
S100A14	57402	broad.mit.edu	37	chr1	153587810	153587810	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtactggtgaaagttcttGatgagggtctcaatggccct	9	12	13	7	0	2	3	1	3	2	0	3	4	2	3	1	3	1	2	1	3	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:153587810G>C	uc001fce.2	-	3	176	c.78C>G	c.(76-78)ATC>ATG	p.I26M	S100A16_uc001fcd.1_5'Flank	NM_020672	NP_065723	Q9HCY8	S10AE_HUMAN	S100 calcium binding protein A14	26					calcium ion homeostasis|defense response to bacterium|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|response to lipopolysaccharide|toll-like receptor 4 signaling pathway	cell junction|microtubule cytoskeleton|perinuclear region of cytoplasm	calcium ion binding|chemokine receptor binding				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAAAGTTCTTGATGAGGGTCT	0.572													20	38					0	0	0	0	C	153587810	C	C	153587810	3	2	214	1	0	0	0	0	1	0	0	0	13841	1280	45	2	244	2	S100A14	1	153587810	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	7269	153587810	95662811	42	38932											
NPR1	4881	broad.mit.edu	37	chr1	153661438	153661438	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgcccccagggagaacagCagcaacatcctggacaacct	12	5	9	15	0	1	1	0	0	1	1	2	3	2	2	4	2	6	2	4	2	3	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:153661438C>T	uc001fcs.3	+	16	2848	c.2427C>T	c.(2425-2427)AGC>AGT	p.S809S	NPR1_uc010pdz.1_Silent_p.S555S|NPR1_uc010pea.1_Silent_p.S287S	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	809	Cytoplasmic (Potential).				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	GGGAGAACAGCAGCAACATCC	0.637													32	100					0	0	0	0	T	153661438	T	T	153661438	2	4	214	1	0	0	0	0	0	0	0	1	10648	709	25	4		4	NPR1	1	153661438	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	73628	153661438	95589183	43	38933											
GATAD2B	57459	broad.mit.edu	37	chr1	153790563	153790563	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaccccttgggccccaggccGagagggaagcttagataggc	10	5	14	12	1	0	2	0	0	0	2	0	4	0	3	5	4	2	1	5	4	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:153790563G>A	uc001fdb.3	-	5	926	c.682C>T	c.(682-684)CGG>TGG	p.R228W		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	228						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCCCCAGGCCGAGAGGGAAGC	0.522													46	129					0	0	0	0	A	153790563	A	A	153790563	3	1	214	1	0	0	0	0	1	0	0	0	6296	1057	37	1	1127	1	GATAD2B	1	153790563	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	129125	153790563	95460058	44	38934											
DENND4B	9909	broad.mit.edu	37	chr1	153911479	153911479	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgtgtgtgcagcagctgaGagtaaagtttgtggctggag	8	12	16	5	0	1	1	0	1	1	1	1	3	1	2	0	2	3	6	0	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:153911479G>C	uc001fdd.1	-	13	2263	c.1862C>G	c.(1861-1863)TCT>TGT	p.S621C		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	621	dDENN.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAGCAGCTGAGAGTAAAGTTT	0.537													4	17					0	0	0	0	C	153911479	C	C	153911479	3	2	214	1	0	0	0	0	1	0	0	0	4456	942	33	2	2692	2	DENND4B	1	153911479	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	120916	153911479	95339142	45	38935											
HAX1	10456	broad.mit.edu	37	chr1	154246316	154246316	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggacagacacttcgggactCaatgcttaagtatccagata	13	9	10	9	1	1	2	1	0	0	2	3	4	2	4	1	2	1	2	1	2	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:154246316C>G	uc001fes.2	+	3	544	c.383C>G	c.(382-384)TCA>TGA	p.S128*	HAX1_uc001fet.2_Nonsense_Mutation_p.S80*|HAX1_uc010peo.1_Nonsense_Mutation_p.S136*|HAX1_uc009wou.2_Nonsense_Mutation_p.S53*|HAX1_uc009wov.2_Nonsense_Mutation_p.S102*	NM_006118	NP_006109	O00165	HAX1_HUMAN	HCLS1 associated protein X-1 isoform a	128	Involved in HCLS1 binding.	Cleavage; by caspase-3.				actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding				0	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTTCGGGACTCAATGCTTAAG	0.557									Kostmann_syndrome				26	103					0	0	0	0	G	154246316	G	G	154246316	4	3	214	1	0	0	0	0	0	1	0	0	7014	838	29	2	393	2	HAX1	1	154246316	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	334837	154246316	95004305	46	38936											
RUSC1	23623	broad.mit.edu	37	chr1	155295461	155295461	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctttatcctgggcctcctCaagtgagttgccttctttcc	4	15	8	14	0	2	1	1	1	1	0	5	1	5	1	6	1	1	1	6	1	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:155295461C>T	uc001fkj.2	+	6	2041	c.1812C>T	c.(1810-1812)CTC>CTT	p.L604L	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fki.2_5'Flank|RUSC1_uc001fkk.2_Silent_p.L604L|RUSC1_uc009wqn.1_Intron|RUSC1_uc009wqo.1_Silent_p.L135L|RUSC1_uc001fkl.2_Silent_p.L194L|RUSC1_uc001fkp.2_Silent_p.L135L|RUSC1_uc001fkq.2_Silent_p.L135L|RUSC1_uc010pgb.1_Silent_p.L102L|RUSC1_uc009wqp.1_Silent_p.L129L|RUSC1_uc001fkn.2_5'UTR|RUSC1_uc001fko.2_RNA|RUSC1_uc001fkr.2_Silent_p.L135L|RUSC1_uc001fks.2_5'UTR	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	604	RUN.					cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TGGGCCTCCTCAAGTGAGTTG	0.612													9	15					0	0	0	0	T	155295461	T	T	155295461	2	4	214	1	0	0	0	0	0	0	0	1	13815	813	29	2		2	RUSC1	1	155295461	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1049145	155295461	93955160	47	38937											
BCAN	63827	broad.mit.edu	37	chr1	156621404	156621405	+	Missense_Mutation	DNP	CC	TT	TT																															atcccgtggggccatctactCcatccccatcatggaggacg																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:156621404_156621405CC>TT	uc001fpp.2	+	7	1556_1557	c.1220_1221CC>TT	c.(1219-1221)TCC>TTT	p.S407F	BCAN_uc001fpo.2_Missense_Mutation_p.S407F	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	407	Glu-rich.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCCATCTACTCCATCCCCATCA	0.569													9	90					0	0	0	0	TT	156621405	TT	TT	156621404	3	4	214	1	0	0	0	0	1	0	0	0	1347	855	30	2	1242	2	BCAN	1	156621404	Missense_Mutation	DNP	CC	TCGA-CV-6961-01A-21D-1912-08	1325943	156621404	92629217	48	38938											
FCRL4	83417	broad.mit.edu	37	chr1	157556066	157556066	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatggcagggagctccagctCtgctctcagggaacgctgag	8	7	15	11	1	2	1	1	1	2	0	4	4	3	3	1	3	4	5	1	3	1	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:157556066C>G	uc001fqw.2	-	6	1163	c.1027G>C	c.(1027-1029)GAG>CAG	p.E343Q	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	343	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				AGCTCCAGCTCTGCTCTCAGG	0.582													24	70					0	0	0	0	G	157556066	G	G	157556066	3	3	214	1	0	0	0	0	1	0	0	0	5829	922	32	2	548	2	FCRL4	1	157556066	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	934662	157556066	91694555	49	38939											
F11R	50848	broad.mit.edu	37	chr1	160970527	160970527	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtgtcacggacttgaaggtGataccagttggcaagaaggt	11	9	14	7	2	1	3	1	2	0	1	1	4	1	4	1	4	1	2	1	4	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:160970527G>A	uc009wtt.2	-	4	552	c.282C>T	c.(280-282)ATC>ATT	p.I94I	F11R_uc010pjv.1_Intron|F11R_uc001fxe.3_Silent_p.I94I|F11R_uc009wtu.2_Silent_p.I94I|F11R_uc010pjw.1_Silent_p.I98I|F11R_uc001fxf.3_Silent_p.I94I	NM_016946	NP_058642	Q9Y624	JAM1_HUMAN	F11 receptor precursor	94	Extracellular (Potential).|Ig-like V-type 1.				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				ovary(2)	2	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			ACTTGAAGGTGATACCAGTTG	0.537													9	46					0	0	0	0	A	160970527	A	A	160970527	2	1	214	1	0	0	0	0	0	0	0	1	5363	1280	45	2		2	F11R	1	160970527	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3414461	160970527	88280094	50	38940											
NR1I3	9970	broad.mit.edu	37	chr1	161199674	161199674	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccgtaggcctcattaatgctCcggagctcagccagcaggcc	8	7	11	15	2	2	0	2	0	0	0	3	1	3	1	5	3	4	4	5	3	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:161199674C>G	uc001fzx.2	-	9	1175	c.972G>C	c.(970-972)CGG>CGC	p.R324R	TOMM40L_uc010pkl.1_3'UTR|TOMM40L_uc001fzd.2_3'UTR|TOMM40L_uc009wue.2_3'UTR|TOMM40L_uc009wuf.1_RNA|TOMM40L_uc001fze.2_3'UTR|NR1I3_uc001fzf.2_Intron|NR1I3_uc001fzg.2_Intron|NR1I3_uc001fzh.2_Silent_p.R296R|NR1I3_uc001fzi.2_Intron|NR1I3_uc001fzj.2_Silent_p.R291R|NR1I3_uc001fzk.2_Intron|NR1I3_uc001fzl.2_Silent_p.R252R|NR1I3_uc001fzm.2_Silent_p.R245R|NR1I3_uc001fzn.2_Silent_p.R114R|NR1I3_uc009wug.2_Intron|NR1I3_uc001fzp.2_Silent_p.R329R|NR1I3_uc001fzo.2_Silent_p.R153R|NR1I3_uc001fzq.2_Intron|NR1I3_uc001fzr.2_3'UTR|NR1I3_uc001fzs.2_Intron|NR1I3_uc001fzt.2_Silent_p.R114R|NR1I3_uc001fzu.2_Intron|NR1I3_uc001fzv.2_3'UTR|NR1I3_uc001fzw.2_Intron|NR1I3_uc001fzy.2_Silent_p.R320R|NR1I3_uc001fzz.2_Silent_p.R286R|NR1I3_uc001gaa.2_Intron|NR1I3_uc001gab.2_Silent_p.R281R|NR1I3_uc001gac.2_Intron	NM_001077480	NP_001070948	Q14994	NR1I3_HUMAN	constitutive androstane receptor isoform 2	324					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(1)|skin(1)	2	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CATTAATGCTCCGGAGCTCAG	0.557													15	44					0	0	0	0	G	161199674	G	G	161199674	2	3	214	1	0	0	0	0	0	0	0	1	10675	842	30	2		2	NR1I3	1	161199674	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	229147	161199674	88050947	51	38941											
FCGR2A	2212	broad.mit.edu	37	chr1	161476260	161476260	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggttccacaatgggaatctCattcccacccacacgcagcc	10	8	7	16	1	1	0	1	0	1	0	4	1	3	1	4	2	1	2	4	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:161476260C>G	uc001gan.2	+	3	296	c.243C>G	c.(241-243)CTC>CTG	p.L81L	FCGR2A_uc001gam.2_Silent_p.L80L|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	81	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATGGGAATCTCATTCCCACCC	0.597													13	75					0	0	0	0	G	161476260	G	G	161476260	2	3	214	1	0	0	0	0	0	0	0	1	5813	813	29	2		2	FCGR2A	1	161476260	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	276586	161476260	87774361	52	38942											
UHMK1	127933	broad.mit.edu	37	chr1	162470803	162470803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtgatacagaatgtacctCagctgttgatctgtggagcc	10	11	12	8	0	2	3	1	2	1	1	2	5	2	4	2	1	4	3	2	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:162470803C>T	uc001gcc.1	+	3	798	c.662C>T	c.(661-663)TCA>TTA	p.S221L	UHMK1_uc001gcb.1_Missense_Mutation_p.S147L|UHMK1_uc009wuu.1_Missense_Mutation_p.S221L	NM_175866	NP_787062	Q8TAS1	UHMK1_HUMAN	kinase interacting stathmin	221	Protein kinase.				cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding				0	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			GAATGTACCTCAGCTGTTGAT	0.443													6	39					0	0	0	0	T	162470803	T	T	162470803	3	4	214	1	0	0	0	0	1	0	0	0	17034	838	29	2	722	2	UHMK1	1	162470803	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	994543	162470803	86779818	53	38943											
C1orf49	84066	broad.mit.edu	37	chr1	178491564	178491564	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgccccaaagtcccagactGagggaaggtgaagcttaact	12	7	11	11	0	0	3	0	2	0	1	1	4	1	4	3	2	3	1	3	2	4	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:178491564G>A	uc001glt.1	+	9	803	c.691G>A	c.(691-693)GAG>AAG	p.E231K	C1orf49_uc001glu.1_3'UTR|C1orf49_uc001glv.1_Intron|C1orf49_uc001glw.1_Intron	NM_032126	NP_115502	Q5T0J7	CA049_HUMAN	hypothetical protein LOC84066	231						microtubule cytoskeleton					0						gtcccagactgagggaaggtg	0.045													5	9					0	0	0	0	A	178491564	A	A	178491564	3	1	214	1	0	0	0	0	1	0	0	0	2051	1291	45	2	806	2	C1orf49	1	178491564	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	16020761	178491564	70759057	54	38944											
DHX9	1660	broad.mit.edu	37	chr1	182853912	182853912	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtcagatctctagaccctCagctgctggtatcaacctta	9	11	7	14	1	4	2	3	0	1	2	5	2	4	2	3	1	3	3	3	1	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:182853912C>T	uc001gpr.2	+	27	3588	c.3425C>T	c.(3424-3426)TCA>TTA	p.S1142L	DHX9_uc001gps.2_Missense_Mutation_p.S928L|DHX9_uc001gpt.2_Missense_Mutation_p.S421L|DHX9_uc009wyd.2_Missense_Mutation_p.S107L	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	1142					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TCTAGACCCTCAGCTGCTGGT	0.448													29	63					0	0	0	0	T	182853912	T	T	182853912	3	4	214	1	0	0	0	0	1	0	0	0	4538	838	29	2	3527	2	DHX9	1	182853912	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4362348	182853912	66396709	55	38945											
OCLM	10896	broad.mit.edu	37	chr1	186370311	186370311	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcatattgttagtactttGaaatttttgctgatgttcaa	10	21	6	4	0	2	2	2	2	0	0	2	2	2	2	0	0	2	4	0	0	5	9			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:186370311G>C	uc001gry.2	+	1	608	c.134G>C	c.(133-135)TGA>TCA	p.*45S	C1orf27_uc001grw.2_Intron|C1orf27_uc010poq.1_Intron|C1orf27_uc010por.1_Intron	NM_022375	NP_071770	Q9Y5M6	TISR_HUMAN	oculomedin	45					visual perception						0						TTAGTACTTTGAAATTTTTGC	0.289													8	21					0	0	0	0	C	186370311	C	C	186370311	4	2	214	1	0	0	0	0	0	0	0	0	10873	1285	45	2	136	2	OCLM	1	186370311	Nonstop_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3516399	186370311	62880310	56	38946											
B3GALT2	8707	broad.mit.edu	37	chr1	193150249	193150249	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtattaaaaaaggacttttCtcttggcatttttcaggctc	11	16	7	7	0	2	0	1	0	1	0	4	1	2	1	0	3	0	3	0	3	4	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:193150249C>T	uc001gtc.3	-	2	1159	c.444G>A	c.(442-444)GAG>GAA	p.E148E	CDC73_uc001gtb.2_Intron	NM_003783	NP_003774	O43825	B3GT2_HUMAN	UDP-Gal:betaGlcNAc beta	148	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1						AAGGACTTTTCTCTTGGCATT	0.368													29	67					0	0	0	0	T	193150249	T	T	193150249	2	4	214	1	0	0	0	0	0	0	0	1	1250	912	32	2		2	B3GALT2	1	193150249	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	6779938	193150249	56100372	57	38947											
KDM5B	10765	broad.mit.edu	37	chr1	202725518	202725518	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagagtttgattttcccatCtcggacaggaaagccactgc	10	11	10	10	1	1	2	0	2	1	1	3	5	2	4	2	2	2	1	2	2	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:202725518C>G	uc001gyf.2	-	10	1440	c.1324G>C	c.(1324-1326)GAT>CAT	p.D442H	KDM5B_uc009xag.2_Missense_Mutation_p.D478H|KDM5B_uc001gyg.1_Missense_Mutation_p.D284H	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	442					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						ATTTTCCCATCTCGGACAGGA	0.418													40	92					0	0	0	0	G	202725518	G	G	202725518	3	3	214	1	0	0	0	0	1	0	0	0	8173	913	32	2	3382	2	KDM5B	1	202725518	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	9575269	202725518	46525103	58	38948											
DSTYK	25778	broad.mit.edu	37	chr1	205138659	205138659	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctggccaggagccccacagTtccagtgactgctgctcaga	8	7	11	15	0	1	2	1	1	0	1	2	3	2	3	5	2	3	3	5	2	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:205138659T>C	uc001hbw.2	-	3	1020	c.956A>G	c.(955-957)AAC>AGC	p.N319S	DSTYK_uc001hbx.2_Missense_Mutation_p.N319S|DSTYK_uc001hby.1_Intron	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	319						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						AGCCCCACAGTTCCAGTGACT	0.498													10	52					0	0	0	0	C	205138659	C	C	205138659	3	2	214	1	0	0	0	0	1	0	0	0	4807	1725	60	5	1877	5	DSTYK	1	205138659	Missense_Mutation	SNP	T	TCGA-CV-6961-01A-21D-1912-08	2413141	205138659	44111962	59	38949											
SLC41A1	254428	broad.mit.edu	37	chr1	205779420	205779420	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgttggcccgagactcaatCaccacctctaccccagcccc	8	6	7	20	2	3	1	2	0	1	1	3	2	3	1	7	1	2	1	7	1	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:205779420C>G	uc001hdh.1	-	2	1022	c.150G>C	c.(148-150)GTG>GTC	p.V50V		NM_173854	NP_776253	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 member 1	50						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			skin(2)	2	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GAGACTCAATCACCACCTCTA	0.642											OREG0014163	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	76					0	0	0	0	G	205779420	G	G	205779420	2	3	214	1	0	0	0	0	0	0	0	1	14693	813	29	2		2	SLC41A1	1	205779420	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	640761	205779420	43471201	60	38950											
SYT14	255928	broad.mit.edu	37	chr1	210334211	210334211	+	Missense_Mutation	SNP	G	A	A																															tggccctatttcagctttctGatgtgacactcatactgtct																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:210334211G>A	uc009xcv.2	+	8	1564	c.1492G>A	c.(1492-1494)GAT>AAT	p.D498N	SYT14_uc001hhs.3_Missense_Mutation_p.D562N|SYT14_uc001hht.3_Missense_Mutation_p.D517N|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Missense_Mutation_p.D543N|SYT14_uc010pso.1_Missense_Mutation_p.D460N|SYT14_uc010psp.1_Missense_Mutation_p.D36N	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	498	Cytoplasmic (Potential).|C2 2.					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		TCAGCTTTCTGATGTGACACT	0.418													18	76					0	0	0	0	A	210334211	A	A	210334211	3	1	214	1	0	0	0	0	1	0	0	0	15536	1290	45	2	1722	2	SYT14	1	210334211	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4554791	210334211	38916410	61	38951	74	2									
SYT14	255928	broad.mit.edu	37	chr1	210334216	210334216	+	Silent	SNP	G	A	A																															ctatttcagctttctgatgtGacactcatactgtctgtgta																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:210334216G>A	uc009xcv.2	+	8	1569	c.1497G>A	c.(1495-1497)GTG>GTA	p.V499V	SYT14_uc001hhs.3_Silent_p.V563V|SYT14_uc001hht.3_Silent_p.V518V|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Silent_p.V544V|SYT14_uc010pso.1_Silent_p.V461V|SYT14_uc010psp.1_Silent_p.V37V	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	499	Cytoplasmic (Potential).|C2 2.					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		TTTCTGATGTGACACTCATAC	0.418													17	77					0	0	0	0	A	210334216	A	A	210334216	2	1	214	1	0	0	0	0	0	0	0	1	15536	1277	45	2		2	SYT14	1	210334216	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5	210334216	38916405	62	38952	74	2									
ESRRG	2104	broad.mit.edu	37	chr1	216850530	216850530	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtctcttgggcatcgagttGagcatgtattcacacttggt	8	14	11	8	1	2	1	1	1	1	0	4	2	2	1	0	2	1	4	0	2	1	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:216850530G>A	uc001hkw.1	-	2	526	c.360C>T	c.(358-360)CTC>CTT	p.L120L	ESRRG_uc001hky.1_Silent_p.L97L|ESRRG_uc009xdp.1_Silent_p.L97L|ESRRG_uc001hkz.1_Silent_p.L97L|ESRRG_uc010puc.1_Silent_p.L97L|ESRRG_uc001hla.1_Silent_p.L97L|ESRRG_uc001hlb.1_Silent_p.L97L|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Silent_p.L97L|ESRRG_uc001hld.1_Silent_p.L97L|ESRRG_uc001hkx.1_Silent_p.L125L|ESRRG_uc009xdo.1_Silent_p.L97L|ESRRG_uc001hle.1_Silent_p.L97L	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	120					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	GCATCGAGTTGAGCATGTATT	0.502													23	103					0	0	0	0	A	216850530	A	A	216850530	2	1	214	1	0	0	0	0	0	0	0	1	5286	1277	45	2		2	ESRRG	1	216850530	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6516314	216850530	32400091	63	38953											
LYPLAL1	127018	broad.mit.edu	37	chr1	219384873	219384873	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtacttcctgaattatttCagtgtcatggtactgcagat	9	16	9	7	0	2	2	2	1	0	1	3	2	3	2	1	1	3	3	1	1	4	5	rs140122550		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:219384873C>T	uc001hlq.3	+	5	558	c.517C>T	c.(517-519)CAG>TAG	p.Q173*	LYPLAL1_uc001hlr.3_Nonsense_Mutation_p.Q157*|LYPLAL1_uc001hls.3_Nonsense_Mutation_p.Q49*|LYPLAL1_uc001hlt.3_Nonsense_Mutation_p.Q49*|LYPLAL1_uc009xds.2_Nonsense_Mutation_p.Q122*	NM_138794	NP_620149	Q5VWZ2	LYPL1_HUMAN	lysophospholipase-like 1	173						cytoplasm	lysophospholipase activity				0				GBM - Glioblastoma multiforme(131;0.055)|all cancers(67;0.105)|OV - Ovarian serous cystadenocarcinoma(81;0.116)		TGAATTATTTCAGTGTCATGG	0.353													29	104					0	0	0	0	T	219384873	T	T	219384873	4	4	214	1	0	0	0	0	0	1	0	0	9169	827	29	2	535	2	LYPLAL1	1	219384873	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2534343	219384873	29865748	64	38954											
KIAA1383	54627	broad.mit.edu	37	chr1	232941206	232941206	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggcaacagcaatggcggcctCgctgtccgagcggctcttct	6	8	13	14	4	2	0	0	0	2	0	4	1	3	0	2	4	3	4	2	4	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:232941206C>G	uc001hvh.2	+	1	569	c.437C>G	c.(436-438)TCG>TGG	p.S146W		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	4										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				ATGGCGGCCTCGCTGTCCGAG	0.632													7	14					0	0	0	0	G	232941206	G	G	232941206	3	3	214	1	0	0	0	0	1	0	0	0	8267	893	31	3	439	3	KIAA1383	1	232941206	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	13556333	232941206	16309415	65	38955											
ARID4B	51742	broad.mit.edu	37	chr1	235345584	235345584	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgtagagattttcttttttCctccaaaccattgtatttct	8	19	4	10	1	2	1	0	0	2	1	4	2	4	1	4	0	1	2	4	0	3	9			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:235345584C>A	uc001hwq.2	-	20	3148	c.2650G>T	c.(2650-2652)GAA>TAA	p.E884*	ARID4B_uc001hwr.2_Nonsense_Mutation_p.E798*|ARID4B_uc001hws.3_Nonsense_Mutation_p.E798*|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Nonsense_Mutation_p.E565*	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	884					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TTTCTTTTTTCCTCCAAACCA	0.343													7	101					0.00307968	0.00316019	1	0	A	235345584	A	A	235345584	4	1	214	1	0	0	0	0	0	1	0	0	920	864	30	2	1308	2	ARID4B	1	235345584	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2404378	235345584	13905037	66	38956											
MAP1LC3C	440738	broad.mit.edu	37	chr1	242162283	242162283	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctgcttgaagggtctgaCgcttgggattttctgtggag	5	14	14	8	1	3	2	0	2	3	0	3	4	3	4	1	3	1	2	1	3	1	4	rs141733716	by1000genomes	TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:242162283C>T	uc001hzk.2	-	1	103	c.28G>A	c.(28-30)GTC>ATC	p.V10I		NM_001004343	NP_001004343	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3	10					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AAGGGTCTGACGCTTGGGATT	0.458											OREG0014354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	61					0	0	0	0	T	242162283	T	T	242162283	3	4	214	1	0	0	0	0	1	0	0	0	9286	536	19	1	431	1	MAP1LC3C	1	242162283	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	6816699	242162283	7088338	67	38957											
OR2C3	81472	broad.mit.edu	37	chr1	247694956	247694956	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggtgtaaataagtgggttCagcgcaggagtgactacggt	11	9	16	5	2	1	1	1	1	0	0	1	2	1	2	0	4	2	3	0	4	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:247694956C>G	uc009xgy.2	-	2	1220	c.858G>C	c.(856-858)CTG>CTC	p.L286L	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TAAGTGGGTTCAGCGCAGGAG	0.547													7	93					0	0	0	0	G	247694956	G	G	247694956	2	3	214	1	0	0	0	0	0	0	0	1	11047	813	29	2		2	OR2C3	1	247694956	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5532673	247694956	1555665	68	38958											
OR2W3	343171	broad.mit.edu	37	chr1	248059216	248059216	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcctgggtctgggtggtGtggagtgcctgcttctggct	1	15	17	8	0	2	0	0	0	2	0	3	1	3	1	2	5	2	3	2	5	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr1:248059216G>C	uc001idp.1	+	3	597	c.328G>C	c.(328-330)GTG>CTG	p.V110L	OR2W3_uc010pzb.1_Missense_Mutation_p.V110L	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TCTGGGTGGTGTGGAGTGCCT	0.577													23	60					0	0	0	0	C	248059216	C	C	248059216	3	2	214	1	0	0	0	0	1	0	0	0	11087	1377	48	4	330	4	OR2W3	1	248059216	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	364260	248059216	1191405	69	38959											
GRHL1	29841	broad.mit.edu	37	chr2	10132193	10132193	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaatggatatcacagttttCaaacccttcattgatctcga	12	13	6	10	2	4	1	3	1	1	0	5	4	4	2	1	1	1	1	1	1	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:10132193C>G	uc002raa.2	+	11	1551	c.1380C>G	c.(1378-1380)TTC>TTG	p.F460L	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.F271L|GRHL1_uc010yjb.1_Missense_Mutation_p.F309L	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	460					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TCACAGTTTTCAAACCCTTCA	0.433													4	26					0	0	0	0	G	10132193	G	G	10132193	3	3	214	1	0	0	0	0	1	0	0	0	6802	825	29	2	1422	2	GRHL1	2	10132193	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08		10132193	233067180	70	38960											
GREB1	9687	broad.mit.edu	37	chr2	11774361	11774361	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgctgggcctgcggaagtGgtccagcaagacccgggcca	7	5	15	14	2	0	1	0	0	0	1	1	2	1	2	5	4	3	2	5	4	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:11774361G>T	uc002rbk.1	+	29	5396	c.5096G>T	c.(5095-5097)TGG>TTG	p.W1699L	GREB1_uc002rbp.1_Missense_Mutation_p.W697L	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1699						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CTGCGGAAGTGGTCCAGCAAG	0.607													16	64					6.31663e-08	6.68268e-08	1	0	T	11774361	T	T	11774361	3	4	214	1	0	0	0	0	1	0	0	0	6799	1357	47	4	5314	4	GREB1	2	11774361	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1642168	11774361	231425012	71	38961											
RAD51AP2	729475	broad.mit.edu	37	chr2	17699613	17699613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggttgggaatccgggtcctCaggaggcgttaaagaggagg	9	8	18	6	2	1	1	1	0	0	1	3	4	3	4	2	7	0	2	2	7	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:17699613C>T	uc002rcl.1	-	1	94	c.70G>A	c.(70-72)GAG>AAG	p.E24K	RAD51AP2_uc010exn.1_Missense_Mutation_p.E15K	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	24										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TCCGGGTCCTCAGGAGGCGTT	0.602													40	109					0	0	0	0	T	17699613	T	T	17699613	3	4	214	1	0	0	0	0	1	0	0	0	13052	835	29	2	3421	2	RAD51AP2	2	17699613	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5925252	17699613	225499760	72	38962											
WDR35	57539	broad.mit.edu	37	chr2	20130163	20130165	+	Nonsense_Mutation	TNP	TCA	ATG	ATG																															ggtgacatgcccacctgtctTcagtgcagtgtccacacatc																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:20130163_20130165TCA>ATG	uc002rdi.2	-	26	3254_3256	c.3146_3148TGA>CAT	c.(3145-3150)CTGAAG>CCATAG	p.1049_1050LK>P*	WDR35_uc002rdj.2_Nonsense_Mutation_p.1038_1039LK>P*|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Nonsense_Mutation_p.522_523LK>P*	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	1049_1050										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCACCTGTCTTCAGTGCAGTGTC	0.433													19	173					0	0	0	0	ATG	20130165	ATG	ATG	20130163	4	1	214	1	0	0	0	0	0	1	0	0	17357	1792	62	5	409	5	WDR35	2	20130163	Nonsense_Mutation	TNP	TCA	TCGA-CV-6961-01A-21D-1912-08	2430550	20130163	223069210	73	38963											
APOB	338	broad.mit.edu	37	chr2	21238409	21238409	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatttttctttcttcctttGtgtcacaactatggtaaaga	9	19	6	7	0	3	2	1	1	2	1	4	2	4	2	1	1	1	1	1	1	4	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:21238409G>A	uc002red.2	-	22	3469	c.3341C>T	c.(3340-3342)ACA>ATA	p.T1114I		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1114					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCTTCCTTTGTGTCACAACT	0.423													6	33					0	0	0	0	A	21238409	A	A	21238409	3	1	214	1	0	0	0	0	1	0	0	0	785	1377	48	4	10382	4	APOB	2	21238409	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1108246	21238409	221960964	74	38964											
CAD	790	broad.mit.edu	37	chr2	27463930	27463930	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatccctcactgcagagctGatgggaacccctgatggcac	9	7	10	15	0	1	3	1	2	0	1	2	4	2	4	4	2	3	3	4	2	1	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:27463930G>A	uc002rji.2	+	37	5805	c.5643G>A	c.(5641-5643)CTG>CTA	p.L1881L	CAD_uc010eyw.2_Silent_p.L1818L	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1881	Linker.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CTGCAGAGCTGATGGGAACCC	0.622													43	101					0	0	0	0	A	27463930	A	A	27463930	2	1	214	1	0	0	0	0	0	0	0	1	2577	1277	45	2		2	CAD	2	27463930	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6225521	27463930	215735443	75	38965											
EPCAM	4072	broad.mit.edu	37	chr2	47601169	47601169	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggacactgaaataacctgctCtgagcgagtgagaacctagt	13	8	11	9	1	1	3	0	3	1	1	1	6	1	4	2	1	4	1	2	1	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:47601169C>G	uc002rvx.2	+	3	765	c.407C>G	c.(406-408)TCT>TGT	p.S136C	EPCAM_uc002rvw.2_Missense_Mutation_p.S164C	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	136	Extracellular (Potential).				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						ATAACCTGCTCTGAGCGAGTG	0.433									Lynch_syndrome				8	39					0	0	0	0	G	47601169	G	G	47601169	3	3	214	1	0	0	0	0	1	0	0	0	5186	913	32	2	417	2	EPCAM	2	47601169	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	20137239	47601169	195598204	76	38966											
RPS27A	6233	broad.mit.edu	37	chr2	55460509	55460509	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acactcataggttgaaccctCggatacgatagaaaatgtaa	16	9	8	8	2	1	2	1	1	0	1	2	4	1	3	1	2	2	2	1	2	7	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:55460509C>G	uc010yow.1	+	3	256	c.59C>G	c.(58-60)TCG>TGG	p.S20W	C2orf63_uc002ryh.2_5'Flank|C2orf63_uc002ryi.2_5'Flank|C2orf63_uc002ryj.2_5'Flank|RPS27A_uc002ryk.2_Missense_Mutation_p.S20W|RPS27A_uc002ryl.2_RNA|RPS27A_uc002rym.2_RNA	NM_001135592	NP_001129064	P62979	RS27A_HUMAN	ubiquitin and ribosomal protein S27a precursor	20	Ubiquitin-like.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	metal ion binding|structural constituent of ribosome			ovary(1)	1						GTTGAACCCTCGGATACGATA	0.408													4	30					0	0	0	0	G	55460509	G	G	55460509	3	3	214	1	0	0	0	0	1	0	0	0	13704	893	31	3	65	3	RPS27A	2	55460509	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	7859340	55460509	187738864	77	38967											
AAK1	22848	broad.mit.edu	37	chr2	69704114	69704114	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctgagatgagattactatCttctgcagcttaatacagaa	14	12	7	8	0	2	3	0	2	2	3	2	5	2	3	1	0	4	2	1	0	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:69704114C>T	uc002sfp.2	-	21	3194	c.2689G>A	c.(2689-2691)GAT>AAT	p.D897N		NM_014911	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	897						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity				0						AGATTACTATCTTCTGCAGCT	0.423													3	11					0	0	0	0	T	69704114	T	T	69704114	3	4	214	1	0	0	0	0	1	0	0	0	16	913	32	2	204	2	AAK1	2	69704114	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	14243605	69704114	173495259	78	38968											
STAMBP	10617	broad.mit.edu	37	chr2	74074516	74074516	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattttctctctttgtagaaGaaggaagcagaggaattggc	13	12	11	5	0	2	3	0	0	2	3	3	5	2	5	0	3	1	2	0	3	6	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:74074516G>C	uc002sjs.2	+	5	428	c.378G>C	c.(376-378)AAG>AAC	p.K126N	STAMBP_uc002sjt.2_Missense_Mutation_p.K126N|STAMBP_uc002sju.2_Missense_Mutation_p.K126N|STAMBP_uc002sjv.2_Missense_Mutation_p.K126N	NM_201647	NP_964010	O95630	STABP_HUMAN	STAM binding protein	126	Glu-rich.|Interaction with CHMP3.				JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			ovary(1)|lung(1)|breast(1)|pancreas(1)	4						CTTTGTAGAAGAAGGAAGCAG	0.448													8	29					0	0	0	0	C	74074516	C	C	74074516	3	2	214	1	0	0	0	0	1	0	0	0	15316	933	33	2	392	2	STAMBP	2	74074516	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4370402	74074516	169124857	79	38969											
MOGS	7841	broad.mit.edu	37	chr2	74690021	74690021	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcagggatcctggcaagcCgaggtagcgttcaggggggg	7	7	18	9	2	2	0	2	0	0	0	3	2	3	1	2	6	2	3	2	6	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:74690021C>T	uc010ffj.2	-	4	1058	c.895G>A	c.(895-897)GGC>AGC	p.G299S	MOGS_uc010ffh.2_Missense_Mutation_p.G24S|MOGS_uc010yrt.1_Missense_Mutation_p.G180S|MOGS_uc010ffi.2_Missense_Mutation_p.G193S|MOGS_uc010yru.1_3'UTR	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	299	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						CCTGGCAAGCCGAGGTAGCGT	0.582													51	134					0	0	0	0	T	74690021	T	T	74690021	3	4	214	1	0	0	0	0	1	0	0	0	9750	652	23	1	1622	1	MOGS	2	74690021	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	615505	74690021	168509352	80	38970											
CAPG	822	broad.mit.edu	37	chr2	85628366	85628366	+	Silent	SNP	C	T	T																															cgctcggtggcacggatgttCttcttccccttcacctggta																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:85628366C>T	uc002spl.1	-	5	688	c.438G>A	c.(436-438)AAG>AAA	p.K146K	CAPG_uc002spm.1_Silent_p.K146K|CAPG_uc010ysq.1_Silent_p.K146K|CAPG_uc010fgi.1_Silent_p.K146K|CAPG_uc010fgj.1_Silent_p.K40K	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	146	Nuclear localization signal (Potential).				barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						CACGGATGTTCTTCTTCCCCT	0.592													34	96					0	0	0	0	T	85628366	T	T	85628366	2	4	214	1	0	0	0	0	0	0	0	1	2633	912	32	2		2	CAPG	2	85628366	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	10938345	85628366	157571007	81	38971	75	2									
CAPG	822	broad.mit.edu	37	chr2	85628369	85628369	+	Missense_Mutation	SNP	C	A	A																															tcggtggcacggatgttcttCttccccttcacctggtagag																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:85628369C>A	uc002spl.1	-	5	685	c.435G>T	c.(433-435)AAG>AAT	p.K145N	CAPG_uc002spm.1_Missense_Mutation_p.K145N|CAPG_uc010ysq.1_Missense_Mutation_p.K145N|CAPG_uc010fgi.1_Missense_Mutation_p.K145N|CAPG_uc010fgj.1_Missense_Mutation_p.K39N	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	145	Nuclear localization signal (Potential).				barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						GGATGTTCTTCTTCCCCTTCA	0.602													34	95					2.75727e-19	3.03571e-19	1	0	A	85628369	A	A	85628369	3	1	214	1	0	0	0	0	1	0	0	0	2633	912	32	2	635	2	CAPG	2	85628369	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3	85628369	157571004	82	38972	75	2									
TTL	150465	broad.mit.edu	37	chr2	113258824	113258824	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagaggcttcagagcttctcGatttcatagacaaccagggc	11	9	10	11	1	3	3	2	0	1	3	4	4	3	3	1	2	2	2	1	2	2	4	rs2943625		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:113258824G>C	uc002thu.2	+	4	690	c.511G>C	c.(511-513)GAT>CAT	p.D171H	TTL_uc010fkm.1_5'Flank	NM_153712	NP_714923	Q8NG68	TTL_HUMAN	tubulin tyrosine ligase	171	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0		Ovarian(717;0.024)		BRCA - Breast invasive adenocarcinoma(221;6.17e-07)|STAD - Stomach adenocarcinoma(1183;0.00644)		AGAGCTTCTCGATTTCATAGA	0.458			T	ETV6	ALL								9	50					0	0	0	0	C	113258824	C	C	113258824	3	2	214	1	0	0	0	0	1	0	0	0	16789	1058	37	3	525	3	TTL	2	113258824	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	27630455	113258824	129940549	83	38973											
TTL	150465	broad.mit.edu	37	chr2	113258890	113258890	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgagcaccctctgctgcttGagccaggtcatcgcaagttt	7	12	10	12	1	2	2	1	2	1	0	3	2	2	2	2	1	4	5	2	1	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:113258890G>C	uc002thu.2	+	4	756	c.577G>C	c.(577-579)GAG>CAG	p.E193Q	TTL_uc010fkm.1_5'Flank	NM_153712	NP_714923	Q8NG68	TTL_HUMAN	tubulin tyrosine ligase	193	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0		Ovarian(717;0.024)		BRCA - Breast invasive adenocarcinoma(221;6.17e-07)|STAD - Stomach adenocarcinoma(1183;0.00644)		TCTGCTGCTTGAGCCAGGTCA	0.463			T	ETV6	ALL								13	49					0	0	0	0	C	113258890	C	C	113258890	3	2	214	1	0	0	0	0	1	0	0	0	16789	1291	45	2	591	2	TTL	2	113258890	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	66	113258890	129940483	84	38974											
CLASP1	23332	broad.mit.edu	37	chr2	122165228	122165228	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagcaaacacttgaggcatCactgttggcatcatcgtcag	12	9	10	10	1	3	2	3	1	0	1	4	2	3	2	0	2	2	4	0	2	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:122165228C>T	uc002tnc.2	-	25	2878	c.2488G>A	c.(2488-2490)GAT>AAT	p.D830N	CLASP1_uc010yyv.1_5'UTR|CLASP1_uc002tmz.2_5'UTR|CLASP1_uc002tna.2_5'UTR|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.D810N|CLASP1_uc010yza.1_Missense_Mutation_p.D802N|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tng.1_Missense_Mutation_p.D801N	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	830					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					CTTGAGGCATCACTGTTGGCA	0.502													38	115					0	0	0	0	T	122165228	T	T	122165228	3	4	214	1	0	0	0	0	1	0	0	0	3469	826	29	2	2188	2	CLASP1	2	122165228	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	8906338	122165228	121034145	85	38975											
LIMS2	55679	broad.mit.edu	37	chr2	128415128	128415128	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggcgttggccaaggcgtccGacatattgctgggggcagga	7	7	17	10	4	0	0	0	0	0	0	1	2	1	1	2	6	1	3	2	6	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:128415128G>A	uc002tpa.2	-	2	186	c.20C>T	c.(19-21)TCG>TTG	p.S7L	LIMS2_uc002tox.2_Missense_Mutation_p.S31L|LIMS2_uc010fmb.2_5'UTR|LIMS2_uc002toy.2_Missense_Mutation_p.S2L|LIMS2_uc010yzm.1_Missense_Mutation_p.S29L|LIMS2_uc002toz.2_Missense_Mutation_p.S2L|LIMS2_uc002tpb.2_Missense_Mutation_p.S2L	NM_001161403	NP_001154875	Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	7					cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		CAAGGCGTCCGACATATTGCT	0.662													24	61					0	0	0	0	A	128415128	A	A	128415128	3	1	214	1	0	0	0	0	1	0	0	0	8845	1059	37	1	1041	1	LIMS2	2	128415128	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6249900	128415128	114784245	86	38976											
R3HDM1	23518	broad.mit.edu	37	chr2	136399347	136399347	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacctggcagtattctgatCaacccacaaacaggttggta	12	9	8	12	0	2	1	1	1	1	0	2	1	2	1	3	3	2	4	3	3	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:136399347C>T	uc002tuo.2	+	15	1831	c.1461C>T	c.(1459-1461)ATC>ATT	p.I487I	R3HDM1_uc010fni.2_Silent_p.I485I|R3HDM1_uc002tup.2_Silent_p.I431I|R3HDM1_uc010zbh.1_Intron	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	487							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		GTATTCTGATCAACCCACAAA	0.418													14	47					0	0	0	0	T	136399347	T	T	136399347	2	4	214	1	0	0	0	0	0	0	0	1	12952	816	29	2		2	R3HDM1	2	136399347	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	7984219	136399347	106800026	87	38977											
NEB	4703	broad.mit.edu	37	chr2	152381070	152381070	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtgtggccttcttgatgtCtggtcgatcagccactgtgg	4	14	13	10	1	3	1	1	1	2	0	4	2	3	1	2	3	1	0	2	3	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:152381070C>G	uc010fnx.2	-	124	17421	c.17230G>C	c.(17230-17232)GAC>CAC	p.D5744H	NEB_uc002txr.2_Missense_Mutation_p.D2167H|NEB_uc002txt.3_Missense_Mutation_p.D249H	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5744	Nebulin 157.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTTGATGTCTGGTCGATCA	0.502													49	146					0	0	0	0	G	152381070	G	G	152381070	3	3	214	1	0	0	0	0	1	0	0	0	10356	913	32	2	3368	2	NEB	2	152381070	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	15981723	152381070	90818303	88	38978											
KCNJ3	3760	broad.mit.edu	37	chr2	155555807	155555807	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgggctccatcgtggacGccttcctcatcggctgcatg	4	11	11	15	3	1	0	1	0	0	0	6	1	4	1	4	3	1	3	4	3	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:155555807G>A	uc002tyv.1	+	1	715	c.520G>A	c.(520-522)GCC>ACC	p.A174T	KCNJ3_uc010zce.1_Missense_Mutation_p.A174T	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	174	Helical; Name=M2; (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	CATCGTGGACGCCTTCCTCAT	0.597													13	49					0	0	0	0	A	155555807	A	A	155555807	3	1	214	1	0	0	0	0	1	0	0	0	8091	1087	38	1	522	1	KCNJ3	2	155555807	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3174737	155555807	87643566	89	38979											
TANC1	85461	broad.mit.edu	37	chr2	160087378	160087378	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgccaaattccagtccactCtcaagagaacaggataacta	15	8	7	11	0	1	1	1	0	1	1	4	3	3	2	3	1	3	0	3	1	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:160087378C>T	uc002uag.2	+	27	5715	c.5441C>T	c.(5440-5442)TCT>TTT	p.S1814F	TANC1_uc010zcm.1_3'UTR|TANC1_uc010fon.2_Missense_Mutation_p.S658F	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1814						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CCAGTCCACTCTCAAGAGAAC	0.463													8	43					0	0	0	0	T	160087378	T	T	160087378	3	4	214	1	0	0	0	0	1	0	0	0	15610	913	32	2	5544	2	TANC1	2	160087378	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4531571	160087378	83111995	90	38980											
SCN2A	6326	broad.mit.edu	37	chr2	166210745	166210745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttttgagttccttcagttCtgacaatcttgctgccactg	6	16	8	11	0	3	2	1	2	2	0	4	2	4	2	2	0	2	4	2	0	1	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:166210745C>T	uc002udc.2	+	17	3253	c.2963C>T	c.(2962-2964)TCT>TTT	p.S988F	SCN2A_uc002udd.2_Missense_Mutation_p.S988F|SCN2A_uc002ude.2_Missense_Mutation_p.S988F	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	988	II.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	TCCTTCAGTTCTGACAATCTT	0.383													40	171					0	0	0	0	T	166210745	T	T	166210745	3	4	214	1	0	0	0	0	1	0	0	0	13981	913	32	2	3121	2	SCN2A	2	166210745	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	6123367	166210745	76988628	91	38981											
SCN1A	6323	broad.mit.edu	37	chr2	166900256	166900256	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgtaggaactgaaggtcCaccaaccaaggaaaccacac	16	4	9	12	1	0	1	0	1	0	0	1	4	1	3	4	3	3	1	4	3	6	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:166900256C>A	uc010zcz.1	-	11	1984	c.1966G>T	c.(1966-1968)GGA>TGA	p.G656*	SCN1A_uc002udo.3_Nonsense_Mutation_p.G525*|SCN1A_uc010fpk.2_Intron	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	656						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	ACTGAAGGTCCACCAACCAAG	0.478													6	75					8.12818e-05	8.40662e-05	1	0	A	166900256	A	A	166900256	4	1	214	1	0	0	0	0	0	1	0	0	13979	603	21	4	4127	4	SCN1A	2	166900256	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	689511	166900256	76299117	92	38982											
NOSTRIN	115677	broad.mit.edu	37	chr2	169684718	169684718	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagggaatgaaatccacagCggacctgcatcagtgagttc	13	7	12	9	1	1	3	1	2	0	1	3	5	2	5	2	2	2	2	2	2	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:169684718C>T	uc002ueg.2	+	4	252	c.248C>T	c.(247-249)GCG>GTG	p.A83V	NOSTRIN_uc002uef.2_Missense_Mutation_p.A83V|NOSTRIN_uc002uei.2_5'UTR|NOSTRIN_uc010fpu.2_Missense_Mutation_p.A55V|NOSTRIN_uc002ueh.2_Missense_Mutation_p.A5V|NOSTRIN_uc002uej.2_5'UTR	NM_001039724	NP_001034813	Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficker isoform 2	83					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0						AAATCCACAGCGGACCTGCAT	0.463													14	48					0	0	0	0	T	169684718	T	T	169684718	3	4	214	1	0	0	0	0	1	0	0	0	10600	768	27	1	262	1	NOSTRIN	2	169684718	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2784462	169684718	73514655	93	38983											
HOXD8	3234	broad.mit.edu	37	chr2	176995585	176995585	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaatatcctgactgtaaatCgtccagtggtaatattggcg	12	12	9	8	2	0	1	0	1	0	0	3	1	2	1	2	2	0	2	2	2	6	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:176995585C>T	uc002uko.2	+	1	1109	c.491C>T	c.(490-492)TCG>TTG	p.S164L	uc002ukl.1_5'Flank|uc002ukm.1_5'Flank|HOXD8_uc002ukn.2_5'UTR|HOXD8_uc002ukp.2_Missense_Mutation_p.S164L	NM_019558	NP_062458	P13378	HXD8_HUMAN	homeobox D8	164					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		GACTGTAAATCGTCCAGTGGT	0.488													25	118					0	0	0	0	T	176995585	T	T	176995585	3	4	214	1	0	0	0	0	1	0	0	0	7364	893	31	1	493	1	HOXD8	2	176995585	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	7310867	176995585	66203788	94	38984											
TTN	7273	broad.mit.edu	37	chr2	179398942	179398942	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccagaaactgggccaatttCaatggatgccactttaactt	12	11	7	11	0	1	1	1	0	0	1	1	2	1	2	3	2	3	0	3	2	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:179398942C>T	uc010zfg.1	-	307	94920	c.94696G>A	c.(94696-94698)GAA>AAA	p.E31566K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E25261K|TTN_uc010zfi.1_Missense_Mutation_p.E25194K|TTN_uc010zfj.1_Missense_Mutation_p.E25069K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32493							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGCCAATTTCAATGGATGCC	0.443													30	86					0	0	0	0	T	179398942	T	T	179398942	3	4	214	1	0	0	0	0	1	0	0	0	16803	835	29	2	5599	2	TTN	2	179398942	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2403357	179398942	63800431	95	38985											
TTN	7273	broad.mit.edu	37	chr2	179498729	179498729	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacatgcattttttcatgaGaaagttcacaaacaaaagtt	16	13	5	7	0	2	1	2	1	0	1	2	2	2	1	0	0	3	3	0	0	5	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:179498729G>A	uc010zfg.1	-	180	35017	c.34793C>T	c.(34792-34794)TCT>TTT	p.S11598F	TTN_uc010zfh.1_Missense_Mutation_p.S5293F|TTN_uc010zfi.1_Missense_Mutation_p.S5226F|TTN_uc010zfj.1_Missense_Mutation_p.S5101F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12525							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTCATGAGAAAGTTCACA	0.368													69	156					0	0	0	0	A	179498729	A	A	179498729	3	1	214	1	0	0	0	0	1	0	0	0	16803	942	33	2	65724	2	TTN	2	179498729	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	99787	179498729	63700644	96	38986											
ZNF385B	151126	broad.mit.edu	37	chr2	180634445	180634445	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcctgtcgttctttatccccTtttcttcaaagccccgtaga	6	15	6	14	2	3	1	1	0	2	1	5	1	4	1	5	0	1	2	5	0	3	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:180634445T>C	uc002unn.3	-	3	642	c.38A>G	c.(37-39)AAG>AGG	p.K13R		NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	13						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			CTTTATCCCCTTTTCTTCAAA	0.423													3	87					0	0	0	0	C	180634445	C	C	180634445	3	2	214	1	0	0	0	0	1	0	0	0	17944	1609	56	5	1438	5	ZNF385B	2	180634445	Missense_Mutation	SNP	T	TCGA-CV-6961-01A-21D-1912-08	1135716	180634445	62564928	97	38987											
SSFA2	6744	broad.mit.edu	37	chr2	182763789	182763789	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttacagtttcatcagaaaggGagaagtatgaattccactgg	14	11	10	6	0	2	3	2	1	0	2	3	4	3	3	1	2	1	2	1	2	5	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:182763789G>A	uc002uoi.2	+	6	775	c.453G>A	c.(451-453)GGG>GGA	p.G151G	SSFA2_uc002uoh.2_Silent_p.G151G|SSFA2_uc002uoj.2_Silent_p.G151G|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_5'UTR|SSFA2_uc002uol.2_5'UTR	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	151						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			ATCAGAAAGGGAGAAGTATGA	0.323													5	27					0	0	0	0	A	182763789	A	A	182763789	2	1	214	1	0	0	0	0	0	0	0	1	15249	1161	41	2		2	SSFA2	2	182763789	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2129344	182763789	60435584	98	38988											
OSGEPL1	64172	broad.mit.edu	37	chr2	190626240	190626240	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtatcatcacaactagtttCaattcccaatactattttat	13	17	2	9	0	3	0	3	0	0	0	4	0	4	0	1	0	2	2	1	0	8	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:190626240C>G	uc002uqz.1	-	2	661	c.127G>C	c.(127-129)GAA>CAA	p.E43Q	OSGEPL1_uc002ura.1_RNA|OSGEPL1_uc010zfy.1_Missense_Mutation_p.E43Q	NM_022353	NP_071748	Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	43					proteolysis|tRNA processing		metalloendopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			CAACTAGTTTCAATTCCCAAT	0.313													10	78					0	0	0	0	G	190626240	G	G	190626240	3	3	214	1	0	0	0	0	1	0	0	0	11342	835	29	2	1145	2	OSGEPL1	2	190626240	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	7862451	190626240	52573133	99	38989											
INPP1	3628	broad.mit.edu	37	chr2	191235867	191235867	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttcagaagataccacattCaaatgggactcttgtgctgc	11	13	8	9	0	3	2	2	0	1	2	3	3	3	3	1	1	3	1	1	1	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:191235867C>G	uc002ury.3	+	7	1639	c.939C>G	c.(937-939)TTC>TTG	p.F313L	INPP1_uc010fsb.2_Missense_Mutation_p.F313L|INPP1_uc002urx.3_Missense_Mutation_p.F313L	NM_001128928	NP_001122400	P49441	INPP_HUMAN	inositol polyphosphate-1-phosphatase	313					signal transduction		inositol-1,4-bisphosphate 1-phosphatase activity|metal ion binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.000286)|Epithelial(96;0.0186)|all cancers(119;0.057)		Lithium(DB01356)	ATACCACATTCAAATGGGACT	0.468													15	55					0	0	0	0	G	191235867	G	G	191235867	3	3	214	1	0	0	0	0	1	0	0	0	7790	825	29	2	957	2	INPP1	2	191235867	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	609627	191235867	51963506	100	38990											
STAT4	6775	broad.mit.edu	37	chr2	191895766	191895766	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacacttggagacatgggaaGaaggtctgatggagaatgtg	13	8	15	5	0	1	4	0	1	1	3	1	7	1	5	0	4	0	0	0	4	3	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:191895766G>A	uc002usm.1	-	23	2406	c.2152C>T	c.(2152-2154)CTT>TTT	p.L718F	STAT4_uc002usn.1_Missense_Mutation_p.L718F	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	718					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GACATGGGAAGAAGGTCTGAT	0.403													35	146					0	0	0	0	A	191895766	A	A	191895766	3	1	214	1	0	0	0	0	1	0	0	0	15333	942	33	2	102	2	STAT4	2	191895766	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	659899	191895766	51303607	101	38991											
SATB2	23314	broad.mit.edu	37	chr2	200173562	200173562	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgactcctcctcatagatgAcatccctctcatgctgggga	8	12	8	13	0	2	3	2	2	1	1	6	4	5	4	3	2	1	1	3	2	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:200173562A>G	uc002uuy.1	-	10	2478	c.1661T>C	c.(1660-1662)GTC>GCC	p.V554A	SATB2_uc010fsq.1_Missense_Mutation_p.V436A|SATB2_uc002uuz.1_Missense_Mutation_p.V554A|SATB2_uc002uva.1_Missense_Mutation_p.V554A	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	554	CUT 2.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCATAGATGACATCCCTCTC	0.597													21	76					0	0	0	0	G	200173562	G	G	200173562	3	3	214	1	0	0	0	0	1	0	0	0	13919	275	10	5	548	5	SATB2	2	200173562	Missense_Mutation	SNP	A	TCGA-CV-6961-01A-21D-1912-08	8277796	200173562	43025811	102	38992											
BMPR2	659	broad.mit.edu	37	chr2	203395617	203395617	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgactttggactgtccatGaggctgactggaaatagact	11	11	12	7	0	0	4	0	3	0	1	1	6	1	6	1	3	0	1	1	3	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:203395617G>A	uc002uzf.3	+	8	2216	c.1068G>A	c.(1066-1068)ATG>ATA	p.M356I	BMPR2_uc010ftr.2_Missense_Mutation_p.M356I	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	356	Protein kinase.|Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						GACTGTCCATGAGGCTGACTG	0.418													9	23					0	0	0	0	A	203395617	A	A	203395617	3	1	214	1	0	0	0	0	1	0	0	0	1474	1290	45	2	1098	2	BMPR2	2	203395617	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3222055	203395617	39803756	103	38993											
GPR1	2825	broad.mit.edu	37	chr2	207041250	207041250	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttgtccagaaatgcctactgGagatcaggatgcttcgcttc	9	12	10	10	1	1	2	1	0	0	2	4	4	2	3	2	2	3	2	2	2	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:207041250G>C	uc002vbl.3	-	3	1108	c.722C>G	c.(721-723)TCC>TGC	p.S241C	GPR1_uc010fue.2_Missense_Mutation_p.S241C|GPR1_uc010fuf.2_Missense_Mutation_p.S241C	NM_005279	NP_005270	P46091	GPR1_HUMAN	G protein-coupled receptor 1	241	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		ATGCCTACTGGAGATCAGGAT	0.443													7	38					0	0	0	0	C	207041250	C	C	207041250	3	2	214	1	0	0	0	0	1	0	0	0	6659	1174	41	2	349	2	GPR1	2	207041250	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3645633	207041250	36158123	104	38994											
CXCR2	3579	broad.mit.edu	37	chr2	219000410	219000410	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaatcacatcgaccgggctCtggatgccaccgagattctg	9	8	11	13	3	3	1	1	0	2	1	4	4	3	2	3	2	1	2	3	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:219000410C>T	uc002vgz.1	+	4	1111	c.886C>T	c.(886-888)CTG>TTG	p.L296L	CXCR2_uc002vha.1_Silent_p.L296L|CXCR2_uc002vhb.1_Silent_p.L296L	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	296	Helical; Name=7; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						CGACCGGGCTCTGGATGCCAC	0.587													34	74					0	0	0	0	T	219000410	T	T	219000410	2	4	214	1	0	0	0	0	0	0	0	1	4108	912	32	2		2	CXCR2	2	219000410	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	11959160	219000410	24198963	105	38995											
PRKAG3	53632	broad.mit.edu	37	chr2	219695504	219695504	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggctccccttcctccaccGacttctgccttgtccatctc	3	13	6	19	1	2	0	0	0	2	0	7	1	6	0	7	1	1	1	7	1	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:219695504G>A	uc002vjb.1	-	3	213	c.194C>T	c.(193-195)TCG>TTG	p.S65L	PRKAG3_uc010zkn.1_RNA|PRKAG3_uc010fvy.1_Missense_Mutation_p.S65L|PRKAG3_uc010zko.1_Missense_Mutation_p.S65L	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	65					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTCCTCCACCGACTTCTGCCT	0.607													28	61					0	0	0	0	A	219695504	A	A	219695504	3	1	214	1	0	0	0	0	1	0	0	0	12564	1059	37	1	1319	1	PRKAG3	2	219695504	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	695094	219695504	23503869	106	38996											
ANKZF1	55139	broad.mit.edu	37	chr2	220099962	220099962	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtggctttactctcctgcAtgcagcagctgcagctggaa	7	10	12	12	1	1	0	0	0	1	0	2	1	1	1	1	3	7	7	1	3	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:220099962A>T	uc002vkg.2	+	10	1793	c.1619A>T	c.(1618-1620)CAT>CTT	p.H540L	ANKZF1_uc010zkv.1_3'UTR|ANKZF1_uc010zkw.1_3'UTR|ANKZF1_uc002vkh.2_Missense_Mutation_p.H330L|ANKZF1_uc002vki.2_Missense_Mutation_p.H540L|ANKZF1_uc002vkj.1_3'UTR	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	540	ANK 2.					intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACTCTCCTGCATGCAGCAGCT	0.587													28	60					0	0	0	0	T	220099962	T	T	220099962	3	4	214	1	0	0	0	0	1	0	0	0	693	217	8	5	1653	5	ANKZF1	2	220099962	Missense_Mutation	SNP	A	TCGA-CV-6961-01A-21D-1912-08	404458	220099962	23099411	107	38997											
ANKZF1	55139	broad.mit.edu	37	chr2	220101166	220101166	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcagggaggccctcttcctGatctcttacagctctacctg	6	11	10	14	0	3	1	0	1	3	0	5	2	4	2	3	3	3	2	3	3	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:220101166G>A	uc002vkg.2	+	14	2354	c.2180G>A	c.(2179-2181)TGA>TAA	p.*727*	ANKZF1_uc002vkh.2_Silent_p.*517*|ANKZF1_uc002vki.2_Silent_p.*727*	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	727						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCTCTTCCTGATCTCTTACA	0.557													12	38					0	0	0	0	A	220101166	A	A	220101166	2	1	214	1	0	0	0	0	0	0	0	1	693	1285	45	2		2	ANKZF1	2	220101166	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1204	220101166	23098207	108	38998											
TMEM198	130612	broad.mit.edu	37	chr2	220412742	220412742	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggcactctggcccctgctCagcctgatgggcgttctggt	3	11	13	14	1	3	1	1	1	2	0	3	1	3	1	3	4	2	3	3	4	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:220412742C>T	uc002vme.2	+	4	1266	c.681C>T	c.(679-681)CTC>CTT	p.L227L	TMEM198_uc002vmf.2_Silent_p.L227L	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	227	Leu-rich.|Helical; (Potential).					integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GGCCCCTGCTCAGCCTGATGG	0.667													3	12					0	0	0	0	T	220412742	T	T	220412742	2	4	214	1	0	0	0	0	0	0	0	1	16185	813	29	2		2	TMEM198	2	220412742	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	311576	220412742	22786631	109	38999											
MOGAT1	116255	broad.mit.edu	37	chr2	223559247	223559247	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatttgttaaaattgctttGacccatgggtaagtggcttt	9	16	11	5	0	0	1	0	1	0	0	0	2	0	2	1	3	1	4	1	3	3	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:223559247G>C	uc010fws.1	+	4	693	c.645G>C	c.(643-645)TTG>TTC	p.L215F	MOGAT1_uc010fwt.1_Missense_Mutation_p.L175F	NM_058165	NP_477513	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	215					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)	1		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)		AAATTGCTTTGACCCATGGGT	0.413													10	23					0	0	0	0	C	223559247	C	C	223559247	3	2	214	1	0	0	0	0	1	0	0	0	9747	1281	45	2	659	2	MOGAT1	2	223559247	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3146505	223559247	19640126	110	39000											
SLC16A14	151473	broad.mit.edu	37	chr2	230902183	230902183	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtaaaaagagtattcctatCatgtaaagcaaaccacatat	19	10	5	7	0	1	1	1	0	0	1	2	1	2	1	2	0	2	4	2	0	9	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:230902183C>G	uc002vqd.1	-	5	1809	c.1446G>C	c.(1444-1446)ATG>ATC	p.M482I	FBXO36_uc010fxi.1_Intron	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	482	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		GTATTCCTATCATGTAAAGCA	0.328													6	31					0	0	0	0	G	230902183	G	G	230902183	3	3	214	1	0	0	0	0	1	0	0	0	14472	826	29	2	90	2	SLC16A14	2	230902183	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	7342936	230902183	12297190	111	39001											
C2orf57	165100	broad.mit.edu	37	chr2	232458485	232458485	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagaacagctacatgcgcTccatgaccagcctgctggac	11	6	11	13	1	0	2	0	1	0	1	1	4	1	3	3	2	6	3	3	2	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:232458485T>C	uc002vrz.2	+	1	874	c.823T>C	c.(823-825)TCC>CCC	p.S275P		NM_152614	NP_689827	Q53QW1	CB057_HUMAN	hypothetical protein LOC165100	275										ovary(1)	1		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		CTACATGCGCTCCATGACCAG	0.662													3	88					0	0	0	0	C	232458485	C	C	232458485	3	2	214	1	0	0	0	0	1	0	0	0	2188	1551	54	5	825	5	C2orf57	2	232458485	Missense_Mutation	SNP	T	TCGA-CV-6961-01A-21D-1912-08	1556302	232458485	10740888	112	39002											
DIS3L2	129563	broad.mit.edu	37	chr2	233001212	233001212	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcttggagaaaaaacattctCgagcagcaaccggcttcctc	12	9	8	12	2	2	1	0	0	2	1	5	3	3	1	2	2	4	3	2	2	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:233001212C>G	uc010fxz.2	+	8	1009	c.733C>G	c.(733-735)CGA>GGA	p.R245G	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	245							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		AAAACATTCTCGAGCAGCAAC	0.433													21	85					0	0	0	0	G	233001212	G	G	233001212	3	3	214	1	0	0	0	0	1	0	0	0	4559	876	31	3	759	3	DIS3L2	2	233001212	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	542727	233001212	10198161	113	39003											
ALPI	248	broad.mit.edu	37	chr2	233321905	233321905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacacgggtgcagcacgcctCgccagccggcacctacgcac	8	3	11	19	5	0	0	0	0	0	0	1	0	0	0	4	2	4	4	4	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:233321905C>T	uc002vst.3	+	5	598	c.521C>T	c.(520-522)TCG>TTG	p.S174L	ALPI_uc002vsu.3_Missense_Mutation_p.S85L	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	174					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CAGCACGCCTCGCCAGCCGGC	0.627													16	50					0	0	0	0	T	233321905	T	T	233321905	3	4	214	1	0	0	0	0	1	0	0	0	543	893	31	1	539	1	ALPI	2	233321905	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	320693	233321905	9877468	114	39004											
INPP5D	3635	broad.mit.edu	37	chr2	234091127	234091127	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaggcaggagtcacttccCagtttgtctccaagaacggt	9	11	11	10	1	2	2	1	1	1	1	4	3	3	3	2	3	1	2	2	3	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr2:234091127C>A	uc010zmo.1	+	18	2296	c.2143C>A	c.(2143-2145)CAG>AAG	p.Q715K	INPP5D_uc010zmp.1_Missense_Mutation_p.Q714K	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	715					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		AGTCACTTCCCAGTTTGTCTC	0.507													18	65					1.33834e-09	1.42744e-09	1	0	A	234091127	A	A	234091127	3	1	214	1	0	0	0	0	1	0	0	0	7795	595	21	4	1725	4	INPP5D	2	234091127	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	769222	234091127	9108246	115	39005											
SETD5	55209	broad.mit.edu	37	chr3	9517533	9517533	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacctcagattcagtttctCagtccagcacaggaactctg	11	10	7	13	0	4	1	3	0	2	1	6	2	5	2	2	1	3	2	2	1	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:9517533C>T	uc003brt.2	+	23	4522	c.4087C>T	c.(4087-4089)CAG>TAG	p.Q1363*	SETD5_uc003bru.2_Nonsense_Mutation_p.Q1265*|SETD5_uc003brv.2_Nonsense_Mutation_p.Q1252*|SETD5_uc010hck.2_Nonsense_Mutation_p.Q845*|SETD5_uc003brx.2_Nonsense_Mutation_p.Q1032*	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	1363	Ser-rich.									ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		TTCAGTTTCTCAGTCCAGCAC	0.552													19	22					0	0	0	0	T	9517533	T	T	9517533	4	4	214	1	0	0	0	0	0	1	0	0	14199	827	29	2	4169	2	SETD5	3	9517533	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08		9517533	188504897	116	39006											
CRELD1	78987	broad.mit.edu	37	chr3	9979762	9979762	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctgaagctctgctgcccCgcaggcaccttcgggccctc	4	8	10	19	2	1	1	0	1	1	0	4	1	2	1	5	2	3	4	5	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:9979762C>T	uc003bug.2	+	5	550	c.432C>T	c.(430-432)CCC>CCT	p.P144P	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Silent_p.P144P|CRELD1_uc003buh.2_Silent_p.P144P|CRELD1_uc003bui.2_Silent_p.P144P|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	144	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						TCTGCTGCCCCGCAGGCACCT	0.552													5	20					0	0	0	0	T	9979762	T	T	9979762	2	4	214	1	0	0	0	0	0	0	0	1	3881	639	23	1		1	CRELD1	3	9979762	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	462229	9979762	188042668	117	39007											
METTL6	131965	broad.mit.edu	37	chr3	15467880	15467880	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctatttcttttgtaaaaaaGatcccaatttttctgagcct	11	17	5	8	0	2	2	0	1	2	1	3	2	3	2	2	0	1	2	2	0	5	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:15467880G>C	uc003bzs.1	-	2	397	c.139C>G	c.(139-141)CTT>GTT	p.L47V	METTL6_uc011avp.1_Missense_Mutation_p.L47V|METTL6_uc003bzt.1_Missense_Mutation_p.L47V|EAF1_uc003bzu.2_5'Flank|EAF1_uc011avq.1_5'Flank	NM_152396	NP_689609	Q8TCB7	METL6_HUMAN	methyltransferase like 6	47							methyltransferase activity				0						TTGTAAAAAAGATCCCAATTT	0.373													14	43					0	0	0	0	C	15467880	C	C	15467880	3	2	214	1	0	0	0	0	1	0	0	0	9557	942	33	2	735	2	METTL6	3	15467880	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5488118	15467880	182554550	118	39008											
EFHB	151651	broad.mit.edu	37	chr3	19924047	19924047	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttatatgctatacctcttCttttgatctggtcttgaaga	8	18	7	8	0	4	3	0	2	4	1	4	3	4	3	1	1	2	2	1	1	5	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:19924047C>G	uc003cbl.3	-	12	2519	c.2323G>C	c.(2323-2325)GAA>CAA	p.E775Q	EFHB_uc003cbm.2_Missense_Mutation_p.E645Q	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	775					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						TATACCTCTTCTTTTGATCTG	0.299													3	9					0	0	0	0	G	19924047	G	G	19924047	3	3	214	1	0	0	0	0	1	0	0	0	4967	922	32	2	186	2	EFHB	3	19924047	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4456167	19924047	178098383	119	39009											
TGFBR2	7048	broad.mit.edu	37	chr3	30691947	30691947	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caatgacaacatcatcttctCagaaggtgagttttcttctc	11	14	6	10	0	5	3	2	2	4	1	7	3	5	3	0	1	1	1	0	1	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:30691947C>G	uc003ceo.2	+	3	831	c.449C>G	c.(448-450)TCA>TGA	p.S150*	TGFBR2_uc003cen.2_Nonsense_Mutation_p.S175*	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	150	Extracellular (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						ATCATCTTCTCAGAAGGTGAG	0.433													17	42					0	0	0	0	G	30691947	G	G	30691947	4	3	214	1	0	0	0	0	0	1	0	0	15888	838	29	2	538	2	TGFBR2	3	30691947	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	10767900	30691947	167330483	120	39010											
TRANK1	9881	broad.mit.edu	37	chr3	36897603	36897603	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aatgaaattcctttgtacctCctggcacagcacatggttct	10	13	7	11	0	1	1	0	1	1	0	3	1	3	1	3	2	2	4	3	2	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:36897603C>G	uc003cgj.2	-	3	2130	c.1828G>C	c.(1828-1830)GAG>CAG	p.E610Q		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1160					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CTTTGTACCTCCTGGCACAGC	0.502													8	117					0	0	0	0	G	36897603	G	G	36897603	3	3	214	1	0	0	0	0	1	0	0	0	16521	864	30	2	5347	2	TRANK1	3	36897603	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	6205656	36897603	161124827	121	39011											
XIRP1	165904	broad.mit.edu	37	chr3	39228635	39228635	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtcccctcagctgcagtctCctggctctcttgcatcctgt	3	13	9	16	0	3	0	1	0	2	0	7	0	5	0	4	2	3	4	4	2	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:39228635C>T	uc003cjk.1	-	2	2523	c.2302G>A	c.(2302-2304)GAG>AAG	p.E768K	XIRP1_uc003cji.2_Missense_Mutation_p.E768K|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	768							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GCTGCAGTCTCCTGGCTCTCT	0.642													11	28					0	0	0	0	T	39228635	T	T	39228635	3	4	214	1	0	0	0	0	1	0	0	0	17497	864	30	2	3233	2	XIRP1	3	39228635	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2331032	39228635	158793795	122	39012											
NKTR	4820	broad.mit.edu	37	chr3	42680839	42680839	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgggaagaaggaggtggctGagaagagccagatcaacctc	13	4	15	9	1	1	4	1	1	0	4	2	7	1	6	3	4	2	1	3	4	4	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:42680839G>C	uc003clo.2	+	13	3790	c.3643G>C	c.(3643-3645)GAG>CAG	p.E1215Q	NKTR_uc003clm.1_Missense_Mutation_p.E962Q|NKTR_uc003clp.2_Missense_Mutation_p.E962Q|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.E1105Q|NKTR_uc003clr.1_Missense_Mutation_p.E962Q|NKTR_uc003cls.2_Missense_Mutation_p.E915Q	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1215					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GGAGGTGGCTGAGAAGAGCCA	0.527													21	43					0	0	0	0	C	42680839	C	C	42680839	3	2	214	1	0	0	0	0	1	0	0	0	10502	1291	45	2	3689	2	NKTR	3	42680839	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3452204	42680839	155341591	123	39013											
NKTR	4820	broad.mit.edu	37	chr3	42680982	42680982	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaatgaaaccacaaggcttGagaatagaaattaaaagcaa	22	6	8	5	0	0	3	0	2	0	2	0	5	0	3	1	1	2	2	1	1	9	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:42680982G>C	uc003clo.2	+	13	3933	c.3786G>C	c.(3784-3786)TTG>TTC	p.L1262F	NKTR_uc003clm.1_Missense_Mutation_p.L1009F|NKTR_uc003clp.2_Missense_Mutation_p.L1009F|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.L1152F|NKTR_uc003clr.1_Missense_Mutation_p.L1009F|NKTR_uc003cls.2_Missense_Mutation_p.L962F	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1262					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CACAAGGCTTGAGAATAGAAA	0.453													27	42					0	0	0	0	C	42680982	C	C	42680982	3	2	214	1	0	0	0	0	1	0	0	0	10502	1281	45	2	3832	2	NKTR	3	42680982	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	143	42680982	155341448	124	39014											
PRKAR2A	5576	broad.mit.edu	37	chr3	48789027	48789027	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgtggcacacctactgcccGaggttgcccagatccacgct	7	8	11	15	2	0	1	0	0	0	1	1	2	1	1	4	2	3	3	4	2	1	2	rs143784793	byFrequency	TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:48789027G>A	uc010hki.1	-	11	1447	c.1206C>T	c.(1204-1206)CTC>CTT	p.L402L	PRKAR2A_uc003cux.1_Silent_p.L402L|PRKAR2A_uc003cuy.1_Silent_p.L380L	NM_004157	NP_004148	P13861	KAP2_HUMAN	cAMP-dependent protein kinase, regulatory	402	cAMP 2.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		CCTACTGCCCGAGGTTGCCCA	0.522													13	14					0	0	0	0	A	48789027	A	A	48789027	2	1	214	1	0	0	0	0	0	0	0	1	12567	1045	37	1		1	PRKAR2A	3	48789027	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6108045	48789027	149233403	125	39015											
BSN	8927	broad.mit.edu	37	chr3	49702266	49702266	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaaaaaattttcctcattCtggtgaccatgcccagcatg	11	11	8	11	0	2	1	1	1	1	0	3	1	3	1	3	2	2	2	3	2	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:49702266C>T	uc003cxe.3	+	10	11889	c.11775C>T	c.(11773-11775)TTC>TTT	p.F3925F		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3925				F -> L (in Ref. 1; AAC83555).	synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TTTCCTCATTCTGGTGACCAT	0.557													30	69					0	0	0	0	T	49702266	T	T	49702266	2	4	214	1	0	0	0	0	0	0	0	1	1535	912	32	2		2	BSN	3	49702266	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	913239	49702266	148320164	126	39016											
DNAH1	25981	broad.mit.edu	37	chr3	52382931	52382931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggaggacatcttcatcagcGgtgaccccctgctggagtcc	7	9	12	13	1	3	1	2	1	1	0	4	4	4	4	3	4	2	1	3	4	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:52382931G>A	uc011bef.1	+	13	2395	c.2134G>A	c.(2134-2136)GGT>AGT	p.G712S	DNAH1_uc003ddt.1_Missense_Mutation_p.G712S	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	712	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTTCATCAGCGGTGACCCCCT	0.617													6	78					0	0	0	0	A	52382931	A	A	52382931	3	1	214	1	0	0	0	0	1	0	0	0	4619	1116	39	1	2180	1	DNAH1	3	52382931	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2680665	52382931	145639499	127	39017											
OR5H15	403274	broad.mit.edu	37	chr3	97887885	97887885	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaaccacagaatgttttctCttggcaacaatggcatatga	13	12	8	8	0	1	2	0	1	1	1	2	2	1	2	1	2	2	4	1	2	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:97887885C>G	uc011bgu.1	+	1	342	c.342C>G	c.(340-342)CTC>CTG	p.L114L		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AATGTTTTCTCTTGGCAACAA	0.378													35	122					0	0	0	0	G	97887885	G	G	97887885	2	3	214	1	0	0	0	0	0	0	0	1	11215	900	32	2		2	OR5H15	3	97887885	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	45504954	97887885	100134545	128	39018											
DCBLD2	131566	broad.mit.edu	37	chr3	98518364	98518364	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatcatactgggcctgggctGaggagcagctgtcagtcctg	7	10	14	10	0	2	1	2	1	0	0	3	2	3	2	2	3	3	3	2	3	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:98518364G>A	uc003dtd.2	-	16	2543	c.2180C>T	c.(2179-2181)TCA>TTA	p.S727L	DCBLD2_uc003dte.2_Missense_Mutation_p.S741L	NM_080927	NP_563615	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	727	Cytoplasmic (Potential).				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3						GGCCTGGGCTGAGGAGCAGCT	0.557													68	233					0	0	0	0	A	98518364	A	A	98518364	3	1	214	1	0	0	0	0	1	0	0	0	4298	1294	45	2	151	2	DCBLD2	3	98518364	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	630479	98518364	99504066	129	39019											
FILIP1L	11259	broad.mit.edu	37	chr3	99649833	99649833	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggaaatttcttttgggctGagccctcggtatcactgcct	6	15	10	10	1	2	1	1	1	1	0	3	2	2	2	2	3	2	2	2	3	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:99649833G>A	uc003dtm.2	-	2	495	c.32C>T	c.(31-33)TCA>TTA	p.S11L	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Missense_Mutation_p.S11L|uc003dtq.2_5'Flank	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	11						cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						CTTTTGGGCTGAGCCCTCGGT	0.433													9	44					0	0	0	0	A	99649833	A	A	99649833	3	1	214	1	0	0	0	0	1	0	0	0	5927	1294	45	2	3416	2	FILIP1L	3	99649833	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1131469	99649833	98372597	130	39020											
C3orf26	84319	broad.mit.edu	37	chr3	99881149	99881149	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctttctcatatcttagaaGaaaattactgatgttcttgc	11	18	5	7	0	4	3	1	1	4	2	5	3	4	3	0	0	2	1	0	0	6	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:99881149G>A	uc003dtl.2	+	4	371	c.228G>A	c.(226-228)AAG>AAA	p.K76K		NM_032359	NP_115735	Q9BQ75	CC026_HUMAN	hypothetical protein LOC84319	76							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1						TATCTTAGAAGAAAATTACTG	0.383													6	51					0	0	0	0	A	99881149	A	A	99881149	2	1	214	1	0	0	0	0	0	0	0	1	2228	933	33	2		2	C3orf26	3	99881149	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	231316	99881149	98141281	131	39021											
NFKBIZ	64332	broad.mit.edu	37	chr3	101572517	101572517	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatgcccagcagcgcctgtGaggccatggtggggcacgag	7	6	17	11	2	0	2	0	2	0	0	0	3	0	2	3	4	3	2	3	4	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:101572517G>A	uc003dvp.2	+	5	1262	c.1147G>A	c.(1147-1149)GAG>AAG	p.E383K	NFKBIZ_uc003dvo.2_Missense_Mutation_p.E283K|NFKBIZ_uc010hpo.2_Missense_Mutation_p.E283K|NFKBIZ_uc003dvq.2_Missense_Mutation_p.E261K	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	383	Required for transcriptional activity (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						CAGCGCCTGTGAGGCCATGGT	0.493													21	124					0	0	0	0	A	101572517	A	A	101572517	3	1	214	1	0	0	0	0	1	0	0	0	10437	1291	45	2	1165	2	NFKBIZ	3	101572517	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1691368	101572517	96449913	132	39022											
CCDC80	151887	broad.mit.edu	37	chr3	112358405	112358405	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacccctcatctctgatcatCtcacgcggagagcccctggc	7	8	9	17	2	4	2	3	1	2	1	6	4	4	2	4	2	1	0	4	2	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:112358405C>T	uc003dzf.2	-	2	566	c.348G>A	c.(346-348)GAG>GAA	p.E116E	CCDC80_uc011bhv.1_Silent_p.E116E|CCDC80_uc003dzg.2_Silent_p.E116E|CCDC80_uc003dzh.1_Silent_p.E116E	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	116										ovary(2)	2						CTCTGATCATCTCACGCGGAG	0.602													27	108					0	0	0	0	T	112358405	T	T	112358405	2	4	214	1	0	0	0	0	0	0	0	1	2867	912	32	2		2	CCDC80	3	112358405	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	10785888	112358405	85664025	133	39023											
KIAA1407	57577	broad.mit.edu	37	chr3	113753906	113753906	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcttcttgcaccagacaCtgagcctccaagaaggccga	10	9	8	14	1	2	3	0	1	2	2	4	4	3	3	4	1	2	1	4	1	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:113753906C>G	uc003eax.2	-	6	831	c.684G>C	c.(682-684)CAG>CAC	p.Q228H	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.Q206H|KIAA1407_uc011bip.1_Missense_Mutation_p.Q215H	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	228	Potential.									ovary(2)	2						GCACCAGACACTGAGCCTCCA	0.448													21	120					0	0	0	0	G	113753906	G	G	113753906	3	3	214	1	0	0	0	0	1	0	0	0	8268	564	20	4	2174	4	KIAA1407	3	113753906	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1395501	113753906	84268524	134	39024											
GTF2E1	2960	broad.mit.edu	37	chr3	120499990	120499990	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgctcattcacgagaaaaaGacttcctctgccatggctgg	10	10	9	12	1	3	2	2	0	1	2	4	3	4	2	2	2	2	2	2	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:120499990G>C	uc003edz.3	+	5	1107	c.993G>C	c.(991-993)AAG>AAC	p.K331N		NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	331					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		ACGAGAAAAAGACTTCCTCTG	0.547													9	63					0	0	0	0	C	120499990	C	C	120499990	3	2	214	1	0	0	0	0	1	0	0	0	6895	933	33	2	1007	2	GTF2E1	3	120499990	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6746084	120499990	77522440	135	39025											
KPNA1	3836	broad.mit.edu	37	chr3	122170899	122170899	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctccagcaatgttgccaaGagcccagactgcctgtgaaa	12	8	9	12	0	1	3	0	1	1	2	2	3	1	3	4	0	4	2	4	0	3	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:122170899G>C	uc003efd.1	-	7	613	c.577C>G	c.(577-579)CTT>GTT	p.L193V	KPNA1_uc003efb.1_5'UTR|KPNA1_uc003efc.1_5'UTR|KPNA1_uc011bjr.1_5'UTR|KPNA1_uc010hrh.2_5'UTR|KPNA1_uc003efe.2_Missense_Mutation_p.L193V	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	193	ARM 3.|NLS binding site (major) (By similarity).				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		ATGTTGCCAAGAGCCCAGACT	0.398													42	176					0	0	0	0	C	122170899	C	C	122170899	3	2	214	1	0	0	0	0	1	0	0	0	8468	942	33	2	1071	2	KPNA1	3	122170899	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1670909	122170899	75851531	136	39026											
ALDH1L1	10840	broad.mit.edu	37	chr3	125879726	125879726	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcctttccatccttgtctgGaacagtgaacacacccacca	10	9	7	15	0	1	1	0	1	1	0	3	2	3	2	5	2	2	0	5	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:125879726G>C	uc003eim.1	-	2	287	c.97C>G	c.(97-99)CCA>GCA	p.P33A	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.P33A|ALDH1L1_uc010hsf.1_5'UTR|ALDH1L1_uc003eip.1_5'Flank|ALDH1L1_uc011bkj.1_5'UTR	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	33	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TCCTTGTCTGGAACAGTGAAC	0.572													15	117					0	0	0	0	C	125879726	C	C	125879726	3	2	214	1	0	0	0	0	1	0	0	0	494	1174	41	2	2699	2	ALDH1L1	3	125879726	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3708827	125879726	72142704	137	39027											
MCM2	4171	broad.mit.edu	37	chr3	127327234	127327234	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccctcgcagaccatctatCagaactaccagcgtatccga	11	8	7	15	3	2	2	1	0	1	2	5	3	4	2	4	0	3	2	4	0	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:127327234C>T	uc003ejp.2	+	7	1168	c.1111C>T	c.(1111-1113)CAG>TAG	p.Q371*	MCM2_uc011bkm.1_Nonsense_Mutation_p.Q241*|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Nonsense_Mutation_p.Q255*	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	371					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						GACCATCTATCAGAACTACCA	0.572													68	229					0	0	0	0	T	127327234	T	T	127327234	4	4	214	1	0	0	0	0	0	1	0	0	9439	827	29	2	1137	2	MCM2	3	127327234	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1447508	127327234	70695196	138	39028											
TMEM108	66000	broad.mit.edu	37	chr3	133109176	133109176	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagtcccttgaaacctctGaggtaatgagcttgaaagtg	11	11	10	9	0	1	4	0	4	1	0	3	4	3	4	3	1	2	2	3	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:133109176G>A	uc003eph.2	+	5	1877	c.1603G>A	c.(1603-1605)GAG>AAG	p.E535K	TMEM108_uc003epi.2_Missense_Mutation_p.E535K|TMEM108_uc003epk.2_Missense_Mutation_p.E65K|TMEM108_uc003epm.2_Missense_Mutation_p.E486K	NM_023943	NP_076432	Q6UXF1	TM108_HUMAN	transmembrane protein 108 precursor	535	Cytoplasmic (Potential).					integral to membrane				ovary(2)|skin(2)	4						TGAAACCTCTGAGGTAATGAG	0.493													43	227					0	0	0	0	A	133109176	A	A	133109176	3	1	214	1	0	0	0	0	1	0	0	0	16090	1291	45	2	1613	2	TMEM108	3	133109176	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5781942	133109176	64913254	139	39029											
TRPC1	7220	broad.mit.edu	37	chr3	142443489	142443489	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catcctcttcctcgccgaacGaggtgatggcgctgaaggat	8	9	12	12	4	1	2	0	2	1	0	4	5	3	3	3	3	1	1	3	3	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:142443489G>A	uc003evc.2	+	1	224	c.88G>A	c.(88-90)GAG>AAG	p.E30K	TRPC1_uc003evb.2_Missense_Mutation_p.E30K	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	30	Cytoplasmic (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						ctcGCCGAACGAGGTGATGGC	0.493													12	65					0	0	0	0	A	142443489	A	A	142443489	3	1	214	1	0	0	0	0	1	0	0	0	16645	1059	37	1	90	1	TRPC1	3	142443489	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9334313	142443489	55578941	140	39030											
SELT	51714	broad.mit.edu	37	chr3	150321201	150321201	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgtctgcgatggtccggagcGaggcctcggccaatctgggc	5	7	16	13	5	2	0	0	0	2	0	4	3	3	1	3	5	2	0	3	5	1	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:150321201G>C	uc011bnx.1	+	1	136	c.52G>C	c.(52-54)GAG>CAG	p.E18Q	SERP1_uc003exz.2_5'Flank|uc003eye.1_5'Flank	NM_016275	NP_057359	P62341	SELT_HUMAN	selenoprotein T precursor	18				RSE -> WSD (in Ref. 4; AAH09611).	cell redox homeostasis|selenocysteine incorporation		selenium binding				0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GGTCCGGAGCGAGGCCTCGGC	0.602													7	29					0	0	0	0	C	150321201	C	C	150321201	3	2	214	1	0	0	0	0	1	0	0	0	14087	1059	37	3	54	3	SELT	3	150321201	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	7877712	150321201	47701229	141	39031											
PLCH1	23007	broad.mit.edu	37	chr3	155200497	155200497	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttcccttccacaaagtcCtcaggattacccttttcctt	7	16	3	15	0	1	0	1	0	0	0	5	1	5	1	5	1	1	0	5	1	2	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:155200497C>T	uc011bok.1	-	23	3619	c.3342G>A	c.(3340-3342)GAG>GAA	p.E1114E	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.E1076E	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1114					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCACAAAGTCCTCAGGATTAC	0.478													28	112					0	0	0	0	T	155200497	T	T	155200497	2	4	214	1	0	0	0	0	0	0	0	1	12092	680	24	4		4	PLCH1	3	155200497	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4879296	155200497	42821933	142	39032											
VEPH1	79674	broad.mit.edu	37	chr3	157188282	157188282	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattcttgtgatacagatttCaactactgcctggtcattgt	9	16	8	8	0	3	2	2	1	1	1	3	3	3	2	1	1	4	0	1	1	3	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:157188282C>T	uc003fbj.1	-	3	492	c.175G>A	c.(175-177)GAA>AAA	p.E59K	VEPH1_uc003fbk.1_Missense_Mutation_p.E59K|VEPH1_uc010hvu.1_Missense_Mutation_p.E59K|VEPH1_uc003fbm.2_Missense_Mutation_p.E59K|VEPH1_uc003fbn.2_Missense_Mutation_p.E59K	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	59						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			ATACAGATTTCAACTACTGCC	0.408													30	121					0	0	0	0	T	157188282	T	T	157188282	3	4	214	1	0	0	0	0	1	0	0	0	17222	835	29	2	2496	2	VEPH1	3	157188282	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1987785	157188282	40834148	143	39033											
RSRC1	51319	broad.mit.edu	37	chr3	157920866	157920866	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctgcttactgtaggtccaGgtcaagacctcgtctccgtt	7	13	9	12	2	3	1	1	0	2	1	6	1	4	1	3	2	2	3	3	2	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:157920866G>A	uc003fbt.2	+	4	437	c.326G>A	c.(325-327)AGG>AAG	p.R109K	RSRC1_uc011bou.1_Intron|RSRC1_uc003fbu.1_Missense_Mutation_p.R109K|RSRC1_uc003fbv.2_Intron	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	109	Arg/Ser-rich.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			TGTAGGTCCAGGTCAAGACCT	0.393													4	45					0	0	0	0	A	157920866	A	A	157920866	3	1	214	1	0	0	0	0	1	0	0	0	13779	1000	35	4	336	4	RSRC1	3	157920866	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	732584	157920866	40101564	144	39034											
SMC4	10051	broad.mit.edu	37	chr3	160137327	160137327	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattccaggaatatatggaaGattggtaaagtagatttttg	14	14	11	2	0	0	2	0	0	0	2	1	5	1	4	1	3	0	2	1	3	7	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:160137327G>T	uc003fdh.2	+	12	1966	c.1853G>T	c.(1852-1854)AGA>ATA	p.R618I	IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Missense_Mutation_p.R382I|SMC4_uc003fdi.2_Missense_Mutation_p.R593I|SMC4_uc003fdj.2_Missense_Mutation_p.R618I|SMC4_uc010hwd.2_Missense_Mutation_p.R618I|SMC4_uc003fdl.2_Missense_Mutation_p.R321I	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	618	Flexible hinge.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ATATATGGAAGATTGGTAAAG	0.353													7	65					8.12818e-05	8.40662e-05	1	0	T	160137327	T	T	160137327	3	4	214	1	0	0	0	0	1	0	0	0	14849	942	33	2	1895	2	SMC4	3	160137327	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2216461	160137327	37885103	145	39035											
GPR160	26996	broad.mit.edu	37	chr3	169802027	169802027	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtacttttaagcattaggttCactaaataccacatctgcct	12	14	5	10	0	2	0	1	0	1	0	2	0	2	0	2	1	4	3	2	1	6	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:169802027C>T	uc003fgi.2	+	4	857	c.267C>T	c.(265-267)TTC>TTT	p.F89F	GPR160_uc010hwq.2_Silent_p.F89F	NM_014373	NP_055188	Q9UJ42	GP160_HUMAN	G protein-coupled receptor 160	89	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_cancers(22;3.26e-22)|all_epithelial(15;5.71e-27)|all_lung(20;8.41e-17)|Lung NSC(18;3.49e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GCATTAGGTTCACTAAATACC	0.303													8	82					0	0	0	0	T	169802027	T	T	169802027	2	4	214	1	0	0	0	0	0	0	0	1	6702	825	29	2		2	GPR160	3	169802027	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	9664700	169802027	28220403	146	39036											
MRPL47	57129	broad.mit.edu	37	chr3	179306692	179306692	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacttttgggcttcagcaaGatgtggaaacttttttaaaa	12	15	9	5	0	1	2	1	1	0	1	1	3	1	3	0	2	2	2	0	2	4	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:179306692G>C	uc003fjz.2	-	7	743	c.721C>G	c.(721-723)CTT>GTT	p.L241V	MRPL47_uc003fka.2_Missense_Mutation_p.L131V|MRPL47_uc003fkb.2_Missense_Mutation_p.L221V	NM_020409	NP_065142	Q9HD33	RM47_HUMAN	mitochondrial ribosomal protein L47 isoform a	241					translation	mitochondrial ribosome	structural constituent of ribosome				0	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)			GCTTCAGCAAGATGTGGAAAC	0.343													13	165					0	0	0	0	C	179306692	C	C	179306692	3	2	214	1	0	0	0	0	1	0	0	0	9864	942	33	2	35	2	MRPL47	3	179306692	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9504665	179306692	18715738	147	39037											
FXR1	8087	broad.mit.edu	37	chr3	180685868	180685868	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagctgtctaacccctctGaaacggaatctgagcgtaaa	12	9	9	11	2	3	3	0	3	3	0	3	4	3	4	2	1	4	2	2	1	5	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:180685868G>A	uc003fkq.2	+	14	1250	c.1228G>A	c.(1228-1230)GAA>AAA	p.E410K	FXR1_uc003fkp.2_Missense_Mutation_p.E325K|FXR1_uc003fkr.2_Missense_Mutation_p.E410K|FXR1_uc011bqj.1_Missense_Mutation_p.E324K|FXR1_uc003fks.2_Missense_Mutation_p.E353K|FXR1_uc011bqk.1_Missense_Mutation_p.E361K|FXR1_uc011bql.1_Missense_Mutation_p.E397K	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	410					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			TAACCCCTCTGAAACGGAATC	0.428													24	161					0	0	0	0	A	180685868	A	A	180685868	3	1	214	1	0	0	0	0	1	0	0	0	6149	1291	45	2	1282	2	FXR1	3	180685868	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1379176	180685868	17336562	148	39038											
MCF2L2	23101	broad.mit.edu	37	chr3	182897459	182897459	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acaggtttcgtgactgtcgtCcgactggaaaaggcccgcga	9	8	13	11	5	0	1	0	1	0	0	3	4	1	2	2	3	0	1	2	3	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:182897459C>G	uc003fli.1	-	29	3217	c.3127G>C	c.(3127-3129)GAC>CAC	p.D1043H		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	1043					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TGACTGTCGTCCGACTGGAAA	0.587													22	225					0	0	0	0	G	182897459	G	G	182897459	3	3	214	1	0	0	0	0	1	0	0	0	9433	855	30	2	225	2	MCF2L2	3	182897459	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2211591	182897459	15124971	149	39039											
AP2M1	1173	broad.mit.edu	37	chr3	183900581	183900581	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcatgaaggaatcgcagatCagcgcagagattgagcttct	12	8	13	8	2	2	4	1	2	1	2	3	6	2	5	0	2	2	4	0	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:183900581C>T	uc011bqx.1	+	11	1255	c.1098C>T	c.(1096-1098)ATC>ATT	p.I366I	AP2M1_uc003fmw.2_Silent_p.I364I|AP2M1_uc003fmx.2_Silent_p.I294I|AP2M1_uc003fmy.2_Silent_p.I364I|AP2M1_uc011bqy.1_Silent_p.I236I|AP2M1_uc011bqz.1_Silent_p.I182I	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	366	MHD.				axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AATCGCAGATCAGCGCAGAGA	0.542													17	93					0	0	0	0	T	183900581	T	T	183900581	2	4	214	1	0	0	0	0	0	0	0	1	742	816	29	2		2	AP2M1	3	183900581	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1003122	183900581	14121849	150	39040											
AHSG	197	broad.mit.edu	37	chr3	186338532	186338532	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gttactggcagctcctccagGacaccagttgcaccgggcgc	7	7	12	15	2	0	0	0	0	0	0	2	1	2	1	4	3	3	5	4	3	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:186338532G>C	uc003fqk.3	+	7	998	c.917G>C	c.(916-918)GGA>GCA	p.G306A	AHSG_uc003fql.3_Missense_Mutation_p.G307A|AHSG_uc003fqm.3_Missense_Mutation_p.G305A|AHSG_uc010hyp.2_Missense_Mutation_p.G269A	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	306					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GCTCCTCCAGGACACCAGTTG	0.632													105	167					0	0	0	0	C	186338532	C	C	186338532	3	2	214	1	0	0	0	0	1	0	0	0	420	1174	41	2	943	2	AHSG	3	186338532	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2437951	186338532	11683898	151	39041											
HRG	3273	broad.mit.edu	37	chr3	186395631	186395631	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggaagttcaagagtgggtttCcacaagtttccatgtttttt	9	16	10	6	0	1	1	1	0	0	1	3	2	3	2	2	2	0	4	2	2	3	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:186395631C>T	uc003fqq.2	+	7	1560	c.1537C>T	c.(1537-1539)CCA>TCA	p.P513S		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	513					fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		GAGTGGGTTTCCACAAGTTTC	0.363													33	88					0	0	0	0	T	186395631	T	T	186395631	3	4	214	1	0	0	0	0	1	0	0	0	7393	855	30	2	1563	2	HRG	3	186395631	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	57099	186395631	11626799	152	39042											
LEPREL1	55214	broad.mit.edu	37	chr3	189681803	189681803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agccacagcacacctctttcCcttggtgactgccttcaccc	7	10	6	18	0	2	1	1	1	1	0	3	1	3	1	5	1	3	1	5	1	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:189681803C>T	uc011bsk.1	-	14	2366	c.1978G>A	c.(1978-1980)GGA>AGA	p.G660R	LEPREL1_uc003fsg.2_Missense_Mutation_p.G479R	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	660	Fe2OG dioxygenase.				collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CACCTCTTTCCCTTGGTGACT	0.493													26	151					0	0	0	0	T	189681803	T	T	189681803	3	4	214	1	0	0	0	0	1	0	0	0	8770	632	22	4	156	4	LEPREL1	3	189681803	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3286172	189681803	8340627	153	39043											
ATP13A4	84239	broad.mit.edu	37	chr3	193185208	193185208	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcttgtaatccgcttcactCtgtgttttccagggcacaga	7	13	9	12	2	2	1	1	0	1	1	4	1	4	1	2	1	0	5	2	1	1	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:193185208C>G	uc003ftd.2	-	10	1119	c.1011G>C	c.(1009-1011)CAG>CAC	p.Q337H	ATP13A4_uc003fte.1_Missense_Mutation_p.Q337H|ATP13A4_uc011bsr.1_5'UTR|ATP13A4_uc010hzi.2_RNA|ATP13A4_uc003ftf.3_Missense_Mutation_p.Q43H	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	337	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CCGCTTCACTCTGTGTTTTCC	0.502													19	163					0	0	0	0	G	193185208	G	G	193185208	3	3	214	1	0	0	0	0	1	0	0	0	1128	912	32	2	2663	2	ATP13A4	3	193185208	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3503405	193185208	4837222	154	39044											
ATP13A3	79572	broad.mit.edu	37	chr3	194152469	194152469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggtcaattgctgatggatGactgcactgcgtgagggagt	8	11	16	6	1	1	3	1	3	0	0	1	5	1	5	0	3	3	2	0	3	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:194152469G>A	uc003fty.3	-	21	2800	c.2398C>T	c.(2398-2400)CAT>TAT	p.H800Y	ATP13A3_uc003ftz.1_Missense_Mutation_p.H506Y	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	800					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		GCTGATGGATGACTGCACTGC	0.388													10	45					0	0	0	0	A	194152469	A	A	194152469	3	1	214	1	0	0	0	0	1	0	0	0	1127	1290	45	2	1330	2	ATP13A3	3	194152469	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	967261	194152469	3869961	155	39045											
TMEM44	93109	broad.mit.edu	37	chr3	194309351	194309351	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttgctgccttcgaggttCacatcttcagggtcccacta	6	14	8	13	1	4	0	2	0	2	0	6	1	5	0	2	2	2	2	2	2	1	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:194309351C>G	uc010hzn.2	-	11	1504	c.1335G>C	c.(1333-1335)GTG>GTC	p.V445V	TMEM44_uc010hzm.2_Nonstop_Mutation_p.*120S|TMEM44_uc003fuc.2_Silent_p.V130V|TMEM44_uc003fue.2_Silent_p.V398V|TMEM44_uc003fud.2_Silent_p.V409V|TMEM44_uc003fuf.2_Nonstop_Mutation_p.*397S|TMEM44_uc011bsv.1_Silent_p.V408V|uc003fug.2_5'Flank	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	445	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		CTTCGAGGTTCACATCTTCAG	0.498													10	235					0	0	0	0	G	194309351	G	G	194309351	2	3	214	1	0	0	0	0	0	0	0	1	16234	837	29	2		2	TMEM44	3	194309351	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	156882	194309351	3713079	156	39046											
MUC4	4585	broad.mit.edu	37	chr3	195515905	195515905	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caccatgactggctgaggcgGacagcaattcggttgttgac	9	9	13	10	2	0	3	0	3	0	0	1	4	0	4	1	4	1	4	1	4	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:195515905G>A	uc011bto.1	-	2	3006	c.2546C>T	c.(2545-2547)TCC>TTC	p.S849F	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.S731F	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	854	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGCTGAGGCGGACAGCAATTC	0.557													13	109					0	0	0	0	A	195515905	A	A	195515905	3	1	214	1	0	0	0	0	1	0	0	0	10031	1174	41	2		2	MUC4	3	195515905	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1206554	195515905	2506525	157	39047											
TNK2	10188	broad.mit.edu	37	chr3	195595101	195595101	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggggcggccgcgcctgctCaggcacaaaggcgtagttgg	7	5	18	11	4	1	0	1	0	0	0	1	0	1	0	2	6	1	4	2	6	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:195595101C>G	uc003fvu.1	-	12	2566	c.2023G>C	c.(2023-2025)GAG>CAG	p.E675Q	TNK2_uc003fvq.1_Missense_Mutation_p.E82Q|TNK2_uc003fvr.1_Missense_Mutation_p.E200Q|TNK2_uc003fvs.1_Missense_Mutation_p.E707Q|TNK2_uc003fvt.1_Missense_Mutation_p.E753Q|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_3'UTR	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	675	Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CGCGCCTGCTCAGGCACAAAG	0.682													10	72					0	0	0	0	G	195595101	G	G	195595101	3	3	214	1	0	0	0	0	1	0	0	0	16384	835	29	2	1109	2	TNK2	3	195595101	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	79196	195595101	2427329	158	39048											
TNK2	10188	broad.mit.edu	37	chr3	195595308	195595308	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtgcccgcgtggggctctGaggcggggtctcgtccagca	4	7	17	13	4	2	1	0	1	2	0	4	1	3	1	2	5	2	2	2	5	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:195595308G>C	uc003fvu.1	-	12	2359	c.1816C>G	c.(1816-1818)CAG>GAG	p.Q606E	TNK2_uc003fvq.1_Missense_Mutation_p.Q13E|TNK2_uc003fvr.1_Missense_Mutation_p.Q131E|TNK2_uc003fvs.1_Missense_Mutation_p.Q638E|TNK2_uc003fvt.1_Missense_Mutation_p.Q684E|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_3'UTR	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	606	Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GTGGGGCTCTGAGGCGGGGTC	0.766													11	22					0	0	0	0	C	195595308	C	C	195595308	3	2	214	1	0	0	0	0	1	0	0	0	16384	1299	45	2	1316	2	TNK2	3	195595308	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	207	195595308	2427122	159	39049											
LRRC33	375387	broad.mit.edu	37	chr3	196386869	196386869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggggacaactgcctctcaGagaactacgaagagacggca	13	5	13	10	2	1	2	1	0	1	2	2	6	1	3	1	3	4	1	1	3	4	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:196386869G>A	uc003fwv.2	+	3	459	c.355G>A	c.(355-357)GAG>AAG	p.E119K		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	119	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CTGCCTCTCAGAGAACTACGA	0.672													7	51					0	0	0	0	A	196386869	A	A	196386869	3	1	214	1	0	0	0	0	1	0	0	0	9038	943	33	2	361	2	LRRC33	3	196386869	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	791561	196386869	1635561	160	39050											
DLG1	1739	broad.mit.edu	37	chr3	196792287	196792287	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaatgataatctcttccatCtacctcataatctcgttttg	12	16	3	10	1	4	1	1	1	3	0	7	1	5	1	2	0	1	1	2	0	5	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:196792287C>T	uc003fxo.3	-	23	2456	c.2266G>A	c.(2266-2268)GAT>AAT	p.D756N	DLG1_uc011bub.1_Missense_Mutation_p.D652N|DLG1_uc011buc.1_Missense_Mutation_p.D640N|DLG1_uc011bud.1_Missense_Mutation_p.D439N|DLG1_uc003fxn.3_Missense_Mutation_p.D778N|DLG1_uc011bue.1_Missense_Mutation_p.D744N|DLG1_uc010ial.2_Missense_Mutation_p.D756N	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	756	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		TCTCTTCCATCTACCTCATAA	0.303													7	135					0	0	0	0	T	196792287	T	T	196792287	3	4	214	1	0	0	0	0	1	0	0	0	4576	913	32	2	464	2	DLG1	3	196792287	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	405418	196792287	1230143	161	39051											
KIAA0226	9711	broad.mit.edu	37	chr3	197427616	197427616	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gacactggacagctggctctCcccacctccttcctggtccc	5	9	8	19	0	1	0	0	0	1	0	5	2	4	1	6	3	1	2	6	3	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr3:197427616C>G	uc003fyc.2	-	7	1312	c.1129G>C	c.(1129-1131)GAG>CAG	p.E377Q	KIAA0226_uc003fyd.3_Missense_Mutation_p.E317Q|KIAA0226_uc003fye.1_Missense_Mutation_p.E84Q|KIAA0226_uc003fyf.2_Missense_Mutation_p.E210Q|KIAA0226_uc003fyg.2_Missense_Mutation_p.E370Q	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	377	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		AGCTGGCTCTCCCCACCTCCT	0.577													35	76					0	0	0	0	G	197427616	G	G	197427616	3	3	214	1	0	0	0	0	1	0	0	0	8201	864	30	2	1894	2	KIAA0226	3	197427616	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	635329	197427616	594814	162	39052											
KLB	152831	broad.mit.edu	37	chr4	39448239	39448239	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcgtggtcagtgaggggctGaagcttggcatctccgcgat	6	10	16	9	3	2	2	1	2	1	0	3	3	2	2	1	4	2	3	1	4	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:39448239G>A	uc003gua.2	+	4	1990	c.1893G>A	c.(1891-1893)CTG>CTA	p.L631L	KLB_uc011byj.1_Silent_p.L622L	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	631	Extracellular (Potential).|Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						GTGAGGGGCTGAAGCTTGGCA	0.627													27	54					0	0	0	0	A	39448239	A	A	39448239	2	1	214	1	0	0	0	0	0	0	0	1	8371	1277	45	2		2	KLB	4	39448239	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08		39448239	151706037	163	39053											
NSUN7	79730	broad.mit.edu	37	chr4	40752778	40752778	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagatcatctcccaactcaCttccctgcctctgtccggtg	6	11	7	17	2	4	1	2	0	2	1	7	2	6	1	4	1	2	0	4	1	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:40752778C>A	uc003gvj.3	+	2	563	c.68C>A	c.(67-69)ACT>AAT	p.T23N	NSUN7_uc003gvh.2_Missense_Mutation_p.T23N|NSUN7_uc003gvi.3_Missense_Mutation_p.T23N	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						TCCCAACTCACTTCCCTGCCT	0.547													29	70					2.65835e-16	2.91453e-16	1	0	A	40752778	A	A	40752778	3	1	214	1	0	0	0	0	1	0	0	0	10737	565	20	4	70	4	NSUN7	4	40752778	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1304539	40752778	150401498	164	39054											
NSUN7	79730	broad.mit.edu	37	chr4	40752873	40752873	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatggcagccaacatttttCagggtattcgaatcgaaaag	13	11	9	8	2	2	0	2	0	0	0	4	2	2	0	1	2	2	2	1	2	5	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:40752873C>G	uc003gvj.3	+	2	658	c.163C>G	c.(163-165)CAG>GAG	p.Q55E	NSUN7_uc003gvh.2_Missense_Mutation_p.Q55E|NSUN7_uc003gvi.3_Missense_Mutation_p.Q55E	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						CAACATTTTTCAGGGTATTCG	0.512													40	94					0	0	0	0	G	40752873	G	G	40752873	3	3	214	1	0	0	0	0	1	0	0	0	10737	827	29	2	165	2	NSUN7	4	40752873	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	95	40752873	150401403	165	39055											
LRRC66	339977	broad.mit.edu	37	chr4	52861814	52861814	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtgtggctgtgtcacccaGaaaggggtctggttctcgta	6	11	16	8	1	3	1	1	0	2	1	4	1	3	1	1	5	0	3	1	5	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:52861814G>C	uc003gzi.2	-	4	1387	c.1374C>G	c.(1372-1374)TTC>TTG	p.F458L		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	458						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GTGTCACCCAGAAAGGGGTCT	0.562													26	72					0	0	0	0	C	52861814	C	C	52861814	3	2	214	1	0	0	0	0	1	0	0	0	9068	933	33	2	1272	2	LRRC66	4	52861814	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	12108941	52861814	138292462	166	39056											
ODAM	54959	broad.mit.edu	37	chr4	71068032	71068032	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaactaggcacagctcctGaaattgctgtgatggtaaga	12	9	10	10	0	0	3	0	2	0	1	1	3	1	3	2	2	3	4	2	2	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:71068032G>A	uc003hfc.2	+	8	651	c.634G>A	c.(634-636)GAA>AAA	p.E212K		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	212					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						CACAGCTCCTGAAATTGCTGT	0.373													12	34					0	0	0	0	A	71068032	A	A	71068032	3	1	214	1	0	0	0	0	1	0	0	0	10878	1291	45	2	664	2	ODAM	4	71068032	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	18206218	71068032	120086244	167	39057											
ENAM	10117	broad.mit.edu	37	chr4	71508386	71508409	+	In_Frame_Del	DEL	ACTACTGTTGCCCCACTGGGTCCC	-	-																															caaataaacaccctgtaggaActactgttgccccactgggt																								rs111931241		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:71508386_71508409delACTACTGTTGCCCCACTGGGTCCC	uc011caw.1	+	9	1524_1547	c.1243_1266delACTACTGTTGCCCCACTGGGTCCC	c.(1243-1266)ACTACTGTTGCCCCACTGGGTCCCdel	p.TTVAPLGP415del		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	415_422					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			CCCTGTAGGAACTACTGTTGCCCCACTGGGTCCCAAACCTGGCC	0.451													---	---	---								-	71508409	-	-	71508386	7	5	214	1	0	1	0	1	0	0	0	0	5136	43	2	0	1273	0	ENAM	4	71508386	In_Frame_Del	DEL	ACTACTGTTGCCCCACTGGGTCCC	TCGA-CV-6961-01A-21D-1912-08	440354	71508386	119645890	168	39058											
ENAM	10117	broad.mit.edu	37	chr4	71508617	71508617	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaattctgttgatcaacatGaaaactcctattacccaaga	15	13	4	9	0	2	3	1	2	1	1	3	3	3	3	2	0	3	1	2	0	7	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:71508617G>A	uc011caw.1	+	9	1755	c.1474G>A	c.(1474-1476)GAA>AAA	p.E492K		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	492					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			TGATCAACATGAAAACTCCTA	0.378													7	30					0	0	0	0	A	71508617	A	A	71508617	3	1	214	1	0	0	0	0	1	0	0	0	5136	1291	45	2	1504	2	ENAM	4	71508617	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	231	71508617	119645659	169	39059											
RUFY3	22902	broad.mit.edu	37	chr4	71660553	71660554	+	Missense_Mutation	DNP	GA	AT	AT																															aaaacaggaaaaagaaagaaGattacaaaacgacaggagca																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:71660553_71660554GA>AT	uc003hfr.2	+	14	2094_2095	c.1499_1500GA>AT	c.(1498-1500)AGA>AAT	p.R500N	RUFY3_uc011cay.1_Missense_Mutation_p.R436N	NM_001037442	NP_001032519	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 1	335	Potential.				negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			AAAGAAAGAAGATTACAAAACG	0.371													6	90					0	0	0	0	AT	71660554	AT	AT	71660553	3	1	214	1	0	0	0	0	1	0	0	0	13805	942	33	2	1996	2	RUFY3	4	71660553	Missense_Mutation	DNP	GA	TCGA-CV-6961-01A-21D-1912-08	151936	71660553	119493723	170	39060											
ADAMTS3	9508	broad.mit.edu	37	chr4	73280574	73280574	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgtctatgggagcctgttCtacagctgatctcttgtaga	8	14	10	9	0	3	2	0	1	3	1	4	3	3	3	1	1	3	3	1	1	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:73280574C>G	uc003hgk.1	-	4	656	c.619G>C	c.(619-621)GAA>CAA	p.E207Q		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	207					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGAGCCTGTTCTACAGCTGAT	0.363													21	52					0	0	0	0	G	73280574	G	G	73280574	3	3	214	1	0	0	0	0	1	0	0	0	267	922	32	2	3074	2	ADAMTS3	4	73280574	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1620021	73280574	117873702	171	39061											
ANKRD17	26057	broad.mit.edu	37	chr4	73957704	73957704	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaggatatgctaatggaaGagaaactggaaaaccaggcc	17	5	13	6	0	0	1	0	0	0	1	0	6	0	5	2	5	3	1	2	5	6	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:73957704G>A	uc003hgp.2	-	29	5758	c.5641C>T	c.(5641-5643)CTT>TTT	p.L1881F	ANKRD17_uc003hgo.2_Missense_Mutation_p.L1768F|ANKRD17_uc003hgq.2_Missense_Mutation_p.L1630F|ANKRD17_uc003hgr.2_Missense_Mutation_p.L1880F	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1881					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GCTAATGGAAGAGAAACTGGA	0.483													21	116					0	0	0	0	A	73957704	A	A	73957704	3	1	214	1	0	0	0	0	1	0	0	0	646	942	33	2	2194	2	ANKRD17	4	73957704	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	677130	73957704	117196572	172	39062											
AFM	173	broad.mit.edu	37	chr4	74361120	74361120	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagaaattgctgcaacacaGaaaaccctccaggttgttac	14	9	8	10	0	0	2	0	1	0	2	1	3	1	2	2	1	5	4	2	1	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:74361120G>A	uc003hhb.2	+	9	1193	c.1162G>A	c.(1162-1164)GAA>AAA	p.E388K		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	388	Albumin 2.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTGCAACACAGAAAACCCTCC	0.363													15	44					0	0	0	0	A	74361120	A	A	74361120	3	1	214	1	0	0	0	0	1	0	0	0	361	943	33	2	1196	2	AFM	4	74361120	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	403416	74361120	116793156	173	39063											
CCNG2	901	broad.mit.edu	37	chr4	78079754	78079754	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctcgggttgttgaacgtCtacctggaacaagaagagag	11	10	12	8	2	2	3	0	1	2	2	3	5	2	4	1	2	3	2	1	2	5	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:78079754C>G	uc003hkq.3	+	2	372	c.69C>G	c.(67-69)GTC>GTG	p.V23V	CCNG2_uc003hkn.3_Silent_p.V23V|CCNG2_uc011ccc.1_Silent_p.V23V|CCNG2_uc003hkp.3_Silent_p.V23V	NM_004354	NP_004345	Q16589	CCNG2_HUMAN	cyclin G2	23					cell cycle checkpoint|cell division|mitosis	cytoplasm				ovary(2)|lung(1)	3						TGTTGAACGTCTACCTGGAAC	0.478													28	87					0	0	0	0	G	78079754	G	G	78079754	2	3	214	1	0	0	0	0	0	0	0	1	2939	900	32	2		2	CCNG2	4	78079754	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3718634	78079754	113074522	174	39064											
FRAS1	80144	broad.mit.edu	37	chr4	79455676	79455676	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcacttaacactgaatttCagctctgcaataatgagaag	15	12	6	8	0	3	2	2	2	1	1	3	3	3	2	0	0	3	2	0	0	5	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:79455676C>T	uc003hlb.2	+	71	11439	c.10999C>T	c.(10999-11001)CAG>TAG	p.Q3667*		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3662	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CACTGAATTTCAGCTCTGCAA	0.418													28	120					0	0	0	0	T	79455676	T	T	79455676	4	4	214	1	0	0	0	0	0	1	0	0	6076	827	29	2	11356	2	FRAS1	4	79455676	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1375922	79455676	111698600	175	39065											
LIN54	132660	broad.mit.edu	37	chr4	83858440	83858440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggccgactggccgactctGatgggattatgctgtacaga	8	9	15	9	2	1	2	0	1	1	1	1	5	1	3	2	4	2	2	2	4	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:83858440G>A	uc003hnx.3	-	9	1922	c.1544C>T	c.(1543-1545)TCA>TTA	p.S515L	LIN54_uc003hnz.3_Missense_Mutation_p.S294L|LIN54_uc003hny.3_Missense_Mutation_p.S114L|LIN54_uc010ijt.2_Missense_Mutation_p.S426L|LIN54_uc010iju.2_Missense_Mutation_p.S114L|LIN54_uc010ijv.2_Missense_Mutation_p.S294L	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	515					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				GGCCGACTCTGATGGGATTAT	0.289													13	54					0	0	0	0	A	83858440	A	A	83858440	3	1	214	1	0	0	0	0	1	0	0	0	8851	1294	45	2	725	2	LIN54	4	83858440	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4402764	83858440	107295836	176	39066											
LIN54	132660	broad.mit.edu	37	chr4	83859644	83859644	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttgctattgatacatatGaagactgctgtagctacatg	11	14	9	7	0	0	3	0	2	0	1	0	3	0	3	0	0	6	5	0	0	6	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:83859644G>A	uc003hnx.3	-	8	1832	c.1454C>T	c.(1453-1455)TCA>TTA	p.S485L	LIN54_uc003hnz.3_Missense_Mutation_p.S264L|LIN54_uc003hny.3_Missense_Mutation_p.S84L|LIN54_uc010ijt.2_Missense_Mutation_p.S396L|LIN54_uc010iju.2_Missense_Mutation_p.S84L|LIN54_uc010ijv.2_Missense_Mutation_p.S264L	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	485					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				TGATACATATGAAGACTGCTG	0.353													4	55					0	0	0	0	A	83859644	A	A	83859644	3	1	214	1	0	0	0	0	1	0	0	0	8851	1294	45	2	819	2	LIN54	4	83859644	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1204	83859644	107294632	177	39067											
WDFY3	23001	broad.mit.edu	37	chr4	85672736	85672736	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcaaaaacgaactttttaGccgggtgattggtcagatat	13	12	10	6	2	2	2	2	1	0	1	2	3	2	2	1	2	3	0	1	2	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:85672736G>C	uc003hpd.2	-	36	6281	c.5873C>G	c.(5872-5874)GCT>GGT	p.A1958G		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1958						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GAACTTTTTAGCCGGGTGATT	0.458													38	91					0	0	0	0	C	85672736	C	C	85672736	3	2	214	1	0	0	0	0	1	0	0	0	17338	971	34	4	4839	4	WDFY3	4	85672736	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1813092	85672736	105481540	178	39068											
PAPSS1	9061	broad.mit.edu	37	chr4	108578142	108578142	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgcccaaccttctgccaaaaCctgcacccactgcatatcca	11	8	4	18	0	1	0	0	0	1	0	2	0	2	0	6	0	6	2	6	0	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:108578142C>T	uc003hyk.2	-	7	889	c.805G>A	c.(805-807)GTT>ATT	p.V269I	PAPSS1_uc011cfh.1_RNA	NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	269	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		TCTGCCAAAACCTGCACCCAC	0.393													11	74					0	0	0	0	T	108578142	T	T	108578142	3	4	214	1	0	0	0	0	1	0	0	0	11488	507	18	4	1093	4	PAPSS1	4	108578142	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	22905406	108578142	82576134	179	39069											
TNIP3	79931	broad.mit.edu	37	chr4	122078303	122078303	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgctgcctgtcgtcctctctCtgcctgtcgtcctttctctg	0	16	8	17	3	3	0	0	0	3	0	9	0	5	0	4	0	2	1	4	0	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:122078303C>T	uc010ing.2	-	4	505	c.309G>A	c.(307-309)CAG>CAA	p.Q103Q	TNIP3_uc010inh.2_Silent_p.Q103Q|TNIP3_uc011cgj.1_Silent_p.Q161Q|TNIP3_uc010ini.2_Silent_p.Q103Q	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	103	Potential.									ovary(1)	1						CGTCCTCTCTCTGCCTGTCGT	0.642													111	275					0	0	0	0	T	122078303	T	T	122078303	2	4	214	1	0	0	0	0	0	0	0	1	16382	912	32	2		2	TNIP3	4	122078303	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	13500161	122078303	69075973	180	39070											
LRBA	987	broad.mit.edu	37	chr4	151773393	151773393	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtaacaggttttccttcttGaaatattaatttgtcatcat	12	18	5	6	0	3	1	2	1	1	0	4	1	4	1	1	1	1	2	1	1	4	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:151773393G>A	uc010ipj.2	-	23	3943	c.3469C>T	c.(3469-3471)CAA>TAA	p.Q1157*	LRBA_uc003ilt.3_5'Flank|LRBA_uc003ilu.3_Nonsense_Mutation_p.Q1157*	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1157						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TTTCCTTCTTGAAATATTAAT	0.383													21	66					0	0	0	0	A	151773393	A	A	151773393	4	1	214	1	0	0	0	0	0	1	0	0	8981	1299	45	2	5266	2	LRBA	4	151773393	Nonsense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	29695090	151773393	39380883	181	39071											
TIGD4	201798	broad.mit.edu	37	chr4	153692046	153692046	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagcaatctctgcttttttCttgccactttccactgcatt	6	17	5	13	0	2	0	0	0	2	0	4	0	3	0	2	0	4	4	2	0	1	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:153692046C>G	uc003imy.2	-	2	893	c.111G>C	c.(109-111)AAG>AAC	p.K37N		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	37	HTH psq-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					CTGCTTTTTTCTTGCCACTTT	0.358													29	55					0	0	0	0	G	153692046	G	G	153692046	3	3	214	1	0	0	0	0	1	0	0	0	15964	912	32	2	1431	2	TIGD4	4	153692046	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1918653	153692046	37462230	182	39072											
DCHS2	54798	broad.mit.edu	37	chr4	155278412	155278412	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaacatctctaaactgttCattacttccttgtctgctga	12	15	4	10	0	3	1	1	1	2	0	5	1	4	1	1	0	4	2	1	0	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:155278412C>G	uc003inw.2	-	6	759	c.759G>C	c.(757-759)ATG>ATC	p.M253I	DCHS2_uc003inx.2_Intron	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	253	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ctaaactgttcattacttcct	0													30	102					0	0	0	0	G	155278412	G	G	155278412	3	3	214	1	0	0	0	0	1	0	0	0	4305	826	29	2	8167	2	DCHS2	4	155278412	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1586366	155278412	35875864	183	39073											
GRIA2	2891	broad.mit.edu	37	chr4	158224904	158224904	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagcttgattgaatactatCaatgggacaagtttgcatac	13	14	8	6	0	1	2	1	2	0	0	1	3	1	3	0	1	4	3	0	1	7	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:158224904C>A	uc003ipm.3	+	3	889	c.430C>A	c.(430-432)CAA>AAA	p.Q144K	GRIA2_uc011cit.1_Missense_Mutation_p.Q97K|GRIA2_uc003ipl.3_Missense_Mutation_p.Q144K|GRIA2_uc003ipk.3_Missense_Mutation_p.Q97K|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	144	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TGAATACTATCAATGGGACAA	0.443													33	106					1.08312e-15	1.18254e-15	1	0	A	158224904	A	A	158224904	3	1	214	1	0	0	0	0	1	0	0	0	6807	827	29	2	440	2	GRIA2	4	158224904	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2946492	158224904	32929372	184	39074											
FNIP2	57600	broad.mit.edu	37	chr4	159791564	159791564	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcttgtgcttcatgggacCggcagtgatgagaagctgaa	10	10	14	7	1	2	3	1	3	1	1	2	6	2	4	1	2	2	3	1	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:159791564C>T	uc003iqe.3	+	14	3075	c.2892C>T	c.(2890-2892)ACC>ACT	p.T964T		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	964					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		TTCATGGGACCGGCAGTGATG	0.552													16	31					0	0	0	0	T	159791564	T	T	159791564	2	4	214	1	0	0	0	0	0	0	0	1	6008	639	23	1		1	FNIP2	4	159791564	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1566660	159791564	31362712	185	39075											
C4orf45	152940	broad.mit.edu	37	chr4	159836377	159836377	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttggaagctcttggcaatGatgacttacactgcctaaca	11	12	9	9	0	1	2	0	2	1	0	1	3	1	3	1	2	4	3	1	2	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:159836377G>A	uc003iqf.1	-	4	576	c.491C>T	c.(490-492)TCA>TTA	p.S164L	C4orf45_uc010iqt.1_RNA	NM_152543	NP_689756	Q96LM5	CD045_HUMAN	hypothetical protein LOC152940	164											0						TCTTGGCAATGATGACTTACA	0.423													12	24					0	0	0	0	A	159836377	A	A	159836377	3	1	214	1	0	0	0	0	1	0	0	0	2283	1294	45	2	77	2	C4orf45	4	159836377	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	44813	159836377	31317899	186	39076											
NEK1	4750	broad.mit.edu	37	chr4	170523167	170523167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatttatctgaccttcaaatGattctctatactggacaata	14	15	4	8	0	3	2	1	2	2	0	4	3	3	3	1	1	1	0	1	1	7	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:170523167G>A	uc003isb.1	-	3	698	c.206C>T	c.(205-207)TCA>TTA	p.S69L	NEK1_uc003isc.1_Missense_Mutation_p.S69L|NEK1_uc003isd.1_Missense_Mutation_p.S69L|NEK1_uc003ise.1_Missense_Mutation_p.S69L|NEK1_uc003isf.1_Missense_Mutation_p.S69L|NEK1_uc003isg.1_5'Flank	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	69	Protein kinase.				cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		ACCTTCAAATGATTCTCTATA	0.328													13	75					0	0	0	0	A	170523167	A	A	170523167	3	1	214	1	0	0	0	0	1	0	0	0	10375	1294	45	2	3698	2	NEK1	4	170523167	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	10686790	170523167	20631109	187	39077											
HMGB2	3148	broad.mit.edu	37	chr4	174254786	174254786	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgccccgcggcttgttgggGtctcctttacccatgttgac	3	14	11	13	2	1	1	0	1	1	0	2	1	1	1	4	3	2	3	4	3	1	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr4:174254786G>A	uc011ckc.1	-	1	135	c.15C>T	c.(13-15)GAC>GAT	p.D5D	HMGB2_uc003ita.3_Silent_p.D5D|HMGB2_uc003itb.2_Silent_p.D5D|HMGB2_uc003itc.2_Silent_p.D5D	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	5					base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		GCTTGTTGGGGTCTCCTTTAC	0.642													4	64					0	0	0	0	A	174254786	A	A	174254786	2	1	214	1	0	0	0	0	0	0	0	1	7265	1252	44	4		4	HMGB2	4	174254786	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3731619	174254786	16899490	188	39078											
AHRR	57491	broad.mit.edu	37	chr5	434023	434023	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcctctggagtgacagggCggagggagactccaggaccc	8	4	18	11	1	1	2	0	1	1	1	2	6	2	5	3	6	0	0	3	6	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:434023C>T	uc003jav.2	+	12	1278	c.1234C>T	c.(1234-1236)CGG>TGG	p.R412W	AHRR_uc003jaw.2_Missense_Mutation_p.R390W|AHRR_uc010isy.2_Missense_Mutation_p.R240W|AHRR_uc010isz.2_Missense_Mutation_p.R390W|AHRR_uc003jax.2_Missense_Mutation_p.R153W|AHRR_uc003jay.2_Missense_Mutation_p.R250W|AHRR_uc003jaz.2_Missense_Mutation_p.R11W	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			AGTGACAGGGCGGAGGGAGAC	0.632													5	37					0	0	0	0	T	434023	T	T	434023	3	4	214	1	0	0	0	0	1	0	0	0	417	759	27	1	1280	1	AHRR	5	434023	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08		434023	180481237	189	39079											
ADAMTS16	170690	broad.mit.edu	37	chr5	5306808	5306808	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgctgctgcgggaccctcGaggggcagctggtttgcctc	3	11	15	12	2	0	0	0	0	0	0	2	2	0	1	2	4	5	5	2	4	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:5306808G>A	uc003jdl.2	+	21	3516	c.3378G>A	c.(3376-3378)TCG>TCA	p.S1126S		NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1126					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CGGGACCCTCGAGGGGCAGCT	0.672													4	34					0	0	0	0	A	5306808	A	A	5306808	2	1	214	1	0	0	0	0	0	0	0	1	261	1045	37	1		1	ADAMTS16	5	5306808	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4872785	5306808	175608452	190	39080											
CDH10	1008	broad.mit.edu	37	chr5	24511615	24511615	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggattcaagaactcgaagatGaatagtgtctgtaaagtata	16	11	10	4	1	2	3	1	1	1	2	3	5	2	4	0	1	1	2	0	1	9	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:24511615G>C	uc003jgr.1	-	6	1155	c.823C>G	c.(823-825)CAT>GAT	p.H275D	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	275	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ACTCGAAGATGAATAGTGTCT	0.279										HNSCC(23;0.051)			7	28					0	0	0	0	C	24511615	C	C	24511615	3	2	214	1	0	0	0	0	1	0	0	0	3111	1290	45	2	1571	2	CDH10	5	24511615	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	19204807	24511615	156403645	191	39081											
SLC1A3	6507	broad.mit.edu	37	chr5	36686317	36686317	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaagaaaccatatcaactGattgcacaggacaatgaaac	19	7	7	8	0	1	4	1	3	0	1	1	5	1	5	1	1	4	1	1	1	6	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:36686317G>A	uc003jkj.3	+	10	2051	c.1575G>A	c.(1573-1575)CTG>CTA	p.L525L	SLC1A3_uc011cox.1_Silent_p.L418L|SLC1A3_uc010iuy.2_Silent_p.L480L	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	525					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	CATATCAACTGATTGCACAGG	0.393													27	185					0	0	0	0	A	36686317	A	A	36686317	2	1	214	1	0	0	0	0	0	0	0	1	14498	1277	45	2		2	SLC1A3	5	36686317	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	12174702	36686317	144228943	192	39082											
NUP155	9631	broad.mit.edu	37	chr5	37307413	37307413	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcacctttcttggaaggcCtgaagtccaactatgtcttc	9	13	8	11	0	2	1	0	1	2	0	4	2	3	2	3	2	2	1	3	2	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:37307413C>G	uc003jku.1	-	25	3007	c.2889G>C	c.(2887-2889)CAG>CAC	p.Q963H	NUP155_uc003jkt.1_Missense_Mutation_p.Q904H|NUP155_uc010iuz.1_Missense_Mutation_p.Q899H	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	963					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTTGGAAGGCCTGAAGTCCAA	0.348													12	65					0	0	0	0	G	37307413	G	G	37307413	3	3	214	1	0	0	0	0	1	0	0	0	10810	680	24	4	1330	4	NUP155	5	37307413	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	621096	37307413	143607847	193	39083											
LIFR	3977	broad.mit.edu	37	chr5	38481936	38481936	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttttatctaagtcctcttCtgcagctatatcttccacag	9	16	5	11	0	4	0	0	0	4	0	6	0	6	0	2	0	2	3	2	0	4	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:38481936C>G	uc010ive.1	-	20	3387	c.3055G>C	c.(3055-3057)GAA>CAA	p.E1019Q	LIFR_uc003jli.2_Missense_Mutation_p.E1019Q	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	1019	Cytoplasmic (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					AAGTCCTCTTCTGCAGCTATA	0.443			T	PLAG1	salivary adenoma								20	99					0	0	0	0	G	38481936	G	G	38481936	3	3	214	1	0	0	0	0	1	0	0	0	8821	922	32	2	242	2	LIFR	5	38481936	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1174523	38481936	142433324	194	39084											
HEATR7B2	133558	broad.mit.edu	37	chr5	41057214	41057214	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggatgctggtcctacctaGaatgagaaaacagcttgaag	13	9	11	8	0	0	3	0	2	0	2	1	5	1	4	2	2	4	2	2	2	6	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:41057214G>C	uc003jmj.3	-	9	1406	c.916C>G	c.(916-918)CTA>GTA	p.L306V	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	306	HEAT 3.						binding			ovary(6)|central_nervous_system(2)	8						GTCCTACCTAGAATGAGAAAA	0.413													10	44					0	0	0	0	C	41057214	C	C	41057214	3	2	214	1	0	0	0	0	1	0	0	0	7074	933	33	2	3977	2	HEATR7B2	5	41057214	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2575278	41057214	139858046	195	39085											
PARP8	79668	broad.mit.edu	37	chr5	50118221	50118221	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatagcataacttctatcaGagaaatgacacaagtaagta	18	9	8	6	0	2	2	1	1	1	1	2	4	2	3	0	1	2	3	0	1	7	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:50118221G>A	uc003jon.3	+	18	2029	c.1847G>A	c.(1846-1848)AGA>AAA	p.R616K	PARP8_uc011cpz.1_Missense_Mutation_p.R508K|PARP8_uc003joo.2_Missense_Mutation_p.R616K|PARP8_uc003jop.2_Missense_Mutation_p.R574K	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	616						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				ACTTCTATCAGAGAAATGACA	0.308													18	96					0	0	0	0	A	50118221	A	A	50118221	3	1	214	1	0	0	0	0	1	0	0	0	11519	942	33	2	1913	2	PARP8	5	50118221	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9061007	50118221	130797039	196	39086											
ADAMTS6	11174	broad.mit.edu	37	chr5	64558671	64558671	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtcacagtgtcttagggatGaggagacgcctcccccgcag	8	8	13	12	2	2	2	1	1	1	1	3	4	3	3	3	2	0	1	3	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:64558671G>A	uc003jtp.2	-	13	2553	c.1739C>T	c.(1738-1740)TCA>TTA	p.S580L	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Missense_Mutation_p.S201L	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	580	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TCTTAGGGATGAGGAGACGCC	0.537													7	12					0	0	0	0	A	64558671	A	A	64558671	3	1	214	1	0	0	0	0	1	0	0	0	270	1294	45	2	1666	2	ADAMTS6	5	64558671	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	14440450	64558671	116356589	197	39087											
BDP1	55814	broad.mit.edu	37	chr5	70786860	70786860	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggaaggtgaatgcagtaaGgagcagatgctttcctgcac	13	8	13	7	0	0	2	0	1	0	1	1	4	1	4	1	3	4	5	1	3	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:70786860G>A	uc003kbp.1	+	11	1805	c.1542G>A	c.(1540-1542)AAG>AAA	p.K514K	BDP1_uc003kbn.1_Silent_p.K514K|BDP1_uc003kbo.2_Silent_p.K514K	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	514					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AATGCAGTAAGGAGCAGATGC	0.383													7	34					0	0	0	0	A	70786860	A	A	70786860	2	1	214	1	0	0	0	0	0	0	0	1	1397	991	35	4		4	BDP1	5	70786860	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6228189	70786860	110128400	198	39088											
MAP1B	4131	broad.mit.edu	37	chr5	71494026	71494026	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctaaagaagaatgcccaaGaccgatgtcaatttctccac	15	9	6	11	1	3	3	1	0	2	3	4	4	3	3	3	0	1	0	3	0	6	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:71494026G>C	uc003kbw.3	+	5	5085	c.4844G>C	c.(4843-4845)AGA>ACA	p.R1615T	MAP1B_uc010iyw.1_Missense_Mutation_p.R1632T|MAP1B_uc010iyx.1_Missense_Mutation_p.R1489T|MAP1B_uc010iyy.1_Missense_Mutation_p.R1489T	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1615						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GAATGCCCAAGACCGATGTCA	0.438													9	107					0	0	0	0	C	71494026	C	C	71494026	3	2	214	1	0	0	0	0	1	0	0	0	9281	942	33	2	4862	2	MAP1B	5	71494026	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	707166	71494026	109421234	199	39089											
CMYA5	202333	broad.mit.edu	37	chr5	79029812	79029812	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggcaacccagaagaatttCagccatttactttttcttta	12	14	6	9	0	2	2	1	0	1	2	2	3	2	2	2	1	3	1	2	1	5	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:79029812C>T	uc003kgc.2	+	2	5296	c.5224C>T	c.(5224-5226)CAG>TAG	p.Q1742*		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1742						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGAAGAATTTCAGCCATTTAC	0.423													11	45					0	0	0	0	T	79029812	T	T	79029812	4	4	214	1	0	0	0	0	0	1	0	0	3605	827	29	2	5230	2	CMYA5	5	79029812	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	7535786	79029812	101885448	200	39090											
GPR98	84059	broad.mit.edu	37	chr5	90074289	90074289	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaaagcttctatgagtttCagctcactgcagtcagtgag	13	11	9	8	0	4	2	3	2	1	0	4	2	4	2	0	0	3	4	0	0	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:90074289C>T	uc003kju.2	+	63	12808	c.12712C>T	c.(12712-12714)CAG>TAG	p.Q4238*	GPR98_uc003kjt.2_Nonsense_Mutation_p.Q1944*|GPR98_uc003kjw.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4238	Extracellular (Potential).|Calx-beta 28.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTATGAGTTTCAGCTCACTGC	0.468													7	20					0	0	0	0	T	90074289	T	T	90074289	4	4	214	1	0	0	0	0	0	1	0	0	6760	827	29	2	12962	2	GPR98	5	90074289	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	11044477	90074289	90840971	201	39091											
ARRDC3	57561	broad.mit.edu	37	chr5	90670857	90670857	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatgataaggattccccaCgcaagttagccacaagctgt	13	8	9	11	1	0	2	0	1	0	1	1	3	1	3	3	1	2	3	3	1	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:90670857C>T	uc003kjz.2	-	5	992	c.752G>A	c.(751-753)CGT>CAT	p.R251H		NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	251					signal transduction	cytoplasm	protein binding			ovary(1)|breast(1)	2		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		GGATTCCCCACGCAAGTTAGC	0.468													13	66					0	0	0	0	T	90670857	T	T	90670857	3	4	214	1	0	0	0	0	1	0	0	0	986	536	19	1	508	1	ARRDC3	5	90670857	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	596568	90670857	90244403	202	39092											
YTHDC2	64848	broad.mit.edu	37	chr5	112851047	112851047	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagtctcttggtttggtctCtaaaagtaaagggtaagctg	10	14	11	6	0	3	0	1	0	2	0	5	0	3	0	0	3	1	4	0	3	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:112851047C>T	uc003kqn.2	+	2	449	c.266C>T	c.(265-267)TCT>TTT	p.S89F	YTHDC2_uc010jce.1_Missense_Mutation_p.S89F|YTHDC2_uc010jcf.1_5'UTR	NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	89	R3H.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		GGTTTGGTCTCTAAAAGTAAA	0.333													15	63					0	0	0	0	T	112851047	T	T	112851047	3	4	214	1	0	0	0	0	1	0	0	0	17565	913	32	2	272	2	YTHDC2	5	112851047	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	22180190	112851047	68064213	203	39093											
YTHDC2	64848	broad.mit.edu	37	chr5	112871369	112871369	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaaagggatcgatttagtGattttttacttacaaagtta	14	16	8	3	1	0	2	0	2	0	0	1	4	0	3	0	1	2	1	0	1	6	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:112871369G>A	uc003kqn.2	+	7	1159	c.976G>A	c.(976-978)GAT>AAT	p.D326N	YTHDC2_uc010jce.1_Missense_Mutation_p.D326N|YTHDC2_uc010jcf.1_Missense_Mutation_p.D26N	NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	326	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TCGATTTAGTGATTTTTTACT	0.303													13	48					0	0	0	0	A	112871369	A	A	112871369	3	1	214	1	0	0	0	0	1	0	0	0	17565	1290	45	2	1002	2	YTHDC2	5	112871369	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	20322	112871369	68043891	204	39094											
YTHDC2	64848	broad.mit.edu	37	chr5	112889016	112889016	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagtagacttggatttgatCatgcatcttctatacaatat	14	15	6	6	0	3	2	1	1	2	1	3	3	3	3	0	1	2	2	0	1	6	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:112889016C>T	uc003kqn.2	+	13	2010	c.1827C>T	c.(1825-1827)ATC>ATT	p.I609I	YTHDC2_uc010jce.1_Silent_p.I609I|YTHDC2_uc010jcf.1_Silent_p.I309I	NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	609							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TGGATTTGATCATGCATCTTC	0.343													9	21					0	0	0	0	T	112889016	T	T	112889016	2	4	214	1	0	0	0	0	0	0	0	1	17565	816	29	2		2	YTHDC2	5	112889016	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	17647	112889016	68026244	205	39095											
ZNF474	133923	broad.mit.edu	37	chr5	121488078	121488078	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaagttgcccaagcatttGaggaggccagaaccctccaa	13	6	10	12	0	0	2	0	1	0	1	1	3	1	3	4	2	4	3	4	2	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:121488078G>C	uc003ksv.2	+	2	769	c.393G>C	c.(391-393)TTG>TTC	p.L131F		NM_207317	NP_997200	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	131						intracellular	zinc ion binding				0		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		CCAAGCATTTGAGGAGGCCAG	0.517													31	78					0	0	0	0	C	121488078	C	C	121488078	3	2	214	1	0	0	0	0	1	0	0	0	17999	1281	45	2	395	2	ZNF474	5	121488078	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	8599062	121488078	59427182	206	39096											
ZNF608	57507	broad.mit.edu	37	chr5	123984351	123984351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgggtctaagtgtgcatGagcctggtggtacctcaggc	6	12	14	9	0	3	1	1	1	2	0	3	1	3	1	2	4	3	2	2	4	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:123984351G>A	uc003ktq.1	-	4	1849	c.1726C>T	c.(1726-1728)CAT>TAT	p.H576Y	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.H576Y|ZNF608_uc003ktt.1_Missense_Mutation_p.H576Y	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	576	C2H2-type.					intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		AAGTGTGCATGAGCCTGGTGG	0.493													28	89					0	0	0	0	A	123984351	A	A	123984351	3	1	214	1	0	0	0	0	1	0	0	0	18101	1290	45	2	2836	2	ZNF608	5	123984351	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2496273	123984351	56930909	207	39097											
FBN2	2201	broad.mit.edu	37	chr5	127599217	127599217	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttcttggaggacgagcactCattcacgtcgtggcaggcac	8	9	13	11	3	3	0	2	0	1	0	4	3	3	2	0	4	1	4	0	4	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:127599217C>G	uc003kuu.2	-	63	8531	c.8092G>C	c.(8092-8094)GAG>CAG	p.E2698Q		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2698	EGF-like 47; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GACGAGCACTCATTCACGTCG	0.602													43	127					0	0	0	0	G	127599217	G	G	127599217	3	3	214	1	0	0	0	0	1	0	0	0	5735	835	29	2	658	2	FBN2	5	127599217	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3614866	127599217	53316043	208	39098											
SLC22A4	6583	broad.mit.edu	37	chr5	131671648	131671648	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cggtgggggtcacatccacgGcctccagagtgggcagcatc	7	6	15	13	2	1	1	1	0	0	1	4	1	3	1	3	5	1	2	3	5	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:131671648G>T	uc003kwq.2	+	8	1564	c.1399G>T	c.(1399-1401)GCC>TCC	p.A467S	uc003kwr.3_Intron	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	467	Helical; Name=11; (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CACATCCACGGCCTCCAGAGT	0.483													15	134					1.99824e-07	2.10835e-07	1	0	T	131671648	T	T	131671648	3	4	214	1	0	0	0	0	1	0	0	0	14520	1203	42	4	1429	4	SLC22A4	5	131671648	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4072431	131671648	49243612	209	39099											
IRF1	3659	broad.mit.edu	37	chr5	131825145	131825145	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgcatctctagccagggtCtcatgcgcatccgagtgatg	7	11	11	12	2	3	1	1	1	3	0	6	2	4	1	2	1	3	2	2	1	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:131825145C>T	uc003kxa.2	-	2	260	c.26G>A	c.(25-27)AGA>AAA	p.R9K	IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Missense_Mutation_p.R9K|IRF1_uc010jdt.1_Missense_Mutation_p.R9K	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	9	IRF tryptophan pentad repeat.				blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		TAGCCAGGGTCTCATGCGCAT	0.493													18	54					0	0	0	0	T	131825145	T	T	131825145	3	4	214	1	0	0	0	0	1	0	0	0	7866	913	32	2	987	2	IRF1	5	131825145	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	153497	131825145	49090115	210	39100											
SPOCK1	6695	broad.mit.edu	37	chr5	136315065	136315065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggagccagccaactcattcCcatatttgtccacacaccag	11	9	6	15	0	1	0	1	0	0	0	3	1	3	1	5	1	3	0	5	1	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:136315065C>T	uc003lbo.2	-	9	1276	c.1085G>A	c.(1084-1086)GGG>GAG	p.G362E	SPOCK1_uc003lbp.2_Missense_Mutation_p.G362E	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	362	Thyroglobulin type-1.				cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CAACTCATTCCCATATTTGTC	0.587													4	104					0	0	0	0	T	136315065	T	T	136315065	3	4	214	1	0	0	0	0	1	0	0	0	15145	623	22	4	242	4	SPOCK1	5	136315065	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4489920	136315065	44600195	211	39101											
KLHL3	26249	broad.mit.edu	37	chr5	137045500	137045500	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accacacggtgggcttctatCtcgacatcttctgccacaat	9	11	7	14	2	4	0	0	0	4	0	5	1	4	0	2	2	1	1	2	2	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:137045500C>T	uc010jek.2	-	3	624	c.180G>A	c.(178-180)GAG>GAA	p.E60E	MYOT_uc011cye.1_Intron|KLHL3_uc010jem.1_Silent_p.E20E	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	60	BTB.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		GGGCTTCTATCTCGACATCTT	0.537													26	100					0	0	0	0	T	137045500	T	T	137045500	2	4	214	1	0	0	0	0	0	0	0	1	8422	912	32	2		2	KLHL3	5	137045500	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	730435	137045500	43869760	212	39102											
SLC4A9	83697	broad.mit.edu	37	chr5	139745591	139745591	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caagtgtgtaaagaccagccGcttcttcccctctgtggtga	8	11	10	12	1	2	2	0	1	2	1	3	2	3	2	4	1	1	2	4	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:139745591G>A	uc003lfm.2	+	13	1990	c.1955G>A	c.(1954-1956)CGC>CAC	p.R652H	SLC4A9_uc003lfj.2_Missense_Mutation_p.R628H|SLC4A9_uc011czg.1_Intron|SLC4A9_uc003lfl.2_Missense_Mutation_p.R628H|SLC4A9_uc003lfk.2_Missense_Mutation_p.R614H	NM_031467	NP_113655	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate	652	Membrane (anion exchange).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGACCAGCCGCTTCTTCCCC	0.493													73	198					0	0	0	0	A	139745591	A	A	139745591	3	1	214	1	0	0	0	0	1	0	0	0	14724	1087	38	1	1933	1	SLC4A9	5	139745591	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2700091	139745591	41169669	213	39103											
PCDHB2	56133	broad.mit.edu	37	chr5	140475302	140475302	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgcttttaagacagaaactgGatttcgaatccatccagaca	14	11	7	9	1	0	3	0	0	0	3	3	5	2	4	2	1	2	1	2	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:140475302G>C	uc003lil.2	+	1	1066	c.928G>C	c.(928-930)GAT>CAT	p.D310H	PCDHB2_uc003lim.1_5'UTR	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	310	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAGAAACTGGATTTCGAATC	0.408													16	49					0	0	0	0	C	140475302	C	C	140475302	3	2	214	1	0	0	0	0	1	0	0	0	11596	1174	41	2	930	2	PCDHB2	5	140475302	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	729711	140475302	40439958	214	39104											
PCDHB6	56130	broad.mit.edu	37	chr5	140530308	140530308	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttcctttgaaaatggcacAcgatttagacaccggcagca	13	10	8	10	2	0	2	0	1	0	1	1	3	1	2	2	2	1	3	2	2	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:140530308A>T	uc003lir.2	+	1	470	c.470A>T	c.(469-471)CAC>CTC	p.H157L	PCDHB6_uc011dah.1_Missense_Mutation_p.H21L	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	157	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAATGGCACACGATTTAGAC	0.483													43	156					0	0	0	0	T	140530308	T	T	140530308	3	4	214	1	0	0	0	0	1	0	0	0	11600	159	6	5	472	5	PCDHB6	5	140530308	Missense_Mutation	SNP	A	TCGA-CV-6961-01A-21D-1912-08	55006	140530308	40384952	215	39105											
PCDHB15	56121	broad.mit.edu	37	chr5	140625408	140625408	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgggcagttgatattaaatGagaagctggaccgggagaag	13	7	15	6	2	0	3	0	2	0	2	0	6	0	4	2	3	1	3	2	3	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:140625408G>A	uc003lje.2	+	1	262	c.262G>A	c.(262-264)GAG>AAG	p.E88K		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	88	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GATATTAAATGAGAAGCTGGA	0.512													5	68					0	0	0	0	A	140625408	A	A	140625408	3	1	214	1	0	0	0	0	1	0	0	0	11594	1291	45	2	264	2	PCDHB15	5	140625408	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	95100	140625408	40289852	216	39106											
GNPDA1	10007	broad.mit.edu	37	chr5	141385711	141385711	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcagagtgtcaagctcacctCcaacaaatagctcgatccca	13	7	7	14	1	2	1	2	0	0	1	5	2	4	1	3	0	3	3	3	0	4	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:141385711C>G	uc003lmf.3	-	3	1166	c.407G>C	c.(406-408)GGA>GCA	p.G136A	GNPDA1_uc003lmg.3_Missense_Mutation_p.G136A|GNPDA1_uc010jgh.2_Missense_Mutation_p.G136A|GNPDA1_uc003lmh.3_Missense_Mutation_p.G102A	NM_005471	NP_005462	P46926	GNPI1_HUMAN	glucosamine-6-phosphate deaminase 1	136					generation of precursor metabolites and energy|glucosamine catabolic process|N-acetylglucosamine metabolic process|single fertilization	cytoplasm	glucosamine-6-phosphate deaminase activity|hydrolase activity				0		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGCTCACCTCCAACAAATAG	0.532													25	76					0	0	0	0	G	141385711	G	G	141385711	3	3	214	1	0	0	0	0	1	0	0	0	6579	855	30	2	478	2	GNPDA1	5	141385711	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	760303	141385711	39529549	217	39107											
RBM27	54439	broad.mit.edu	37	chr5	145651095	145651095	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgaggaaagaccatgtcctCtcaaggtcgaggaagaggcc	12	6	13	10	2	1	2	1	0	1	2	5	6	2	4	3	4	0	0	3	4	3	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:145651095C>G	uc003lnz.3	+	19	3012	c.2846C>G	c.(2845-2847)TCT>TGT	p.S949C		NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	949					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCATGTCCTCTCAAGGTCGA	0.478													8	30					0	0	0	0	G	145651095	G	G	145651095	3	3	214	1	0	0	0	0	1	0	0	0	13192	913	32	2	2920	2	RBM27	5	145651095	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4265384	145651095	35264165	218	39108											
SLC6A7	6534	broad.mit.edu	37	chr5	149576346	149576346	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccctcttcttcctggagctCtccctgggccagttctccag	3	12	8	18	0	4	0	0	0	4	0	7	1	5	1	6	2	1	2	6	2	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:149576346C>G	uc003lrr.2	+	3	656	c.285C>G	c.(283-285)CTC>CTG	p.L95L		NM_014228	NP_055043	Q99884	SC6A7_HUMAN	solute carrier family 6, member 7	95						integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity				0		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	TCCTGGAGCTCTCCCTGGGCC	0.642													39	115					0	0	0	0	G	149576346	G	G	149576346	2	3	214	1	0	0	0	0	0	0	0	1	14753	900	32	2		2	SLC6A7	5	149576346	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3925251	149576346	31338914	219	39109											
GALNT10	55568	broad.mit.edu	37	chr5	153760021	153760021	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcttcagaccgcattgctcgGaaccgcaagaccattgtgtg	9	10	10	12	3	2	2	1	0	1	2	3	3	2	3	3	1	2	3	3	1	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:153760021G>A	uc003lvh.2	+	6	900	c.768G>A	c.(766-768)CGG>CGA	p.R256R	GALNT10_uc003lvg.1_Silent_p.R256R|GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Silent_p.R97R	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	256	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GCATTGCTCGGAACCGCAAGA	0.512													43	126					0	0	0	0	A	153760021	A	A	153760021	2	1	214	1	0	0	0	0	0	0	0	1	6243	1161	41	2		2	GALNT10	5	153760021	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4183675	153760021	27155239	220	39110											
RNF145	153830	broad.mit.edu	37	chr5	158585719	158585719	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttcatctttcgcactgtGaggatattctttggggtcaa	7	16	10	8	1	4	1	2	1	2	0	5	2	4	2	0	3	1	2	0	3	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:158585719G>A	uc003lxp.2	-	11	2264	c.1951C>T	c.(1951-1953)CAC>TAC	p.H651Y	RNF145_uc011ddy.1_Missense_Mutation_p.H665Y|RNF145_uc003lxo.1_Missense_Mutation_p.H679Y|RNF145_uc011ddz.1_Missense_Mutation_p.H668Y|RNF145_uc010jiq.1_Missense_Mutation_p.H681Y	NM_144726	NP_653327	Q96MT1	RN145_HUMAN	ring finger protein 145	651						integral to membrane	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCGCACTGTGAGGATATTCT	0.473													34	159					0	0	0	0	A	158585719	A	A	158585719	3	1	214	1	0	0	0	0	1	0	0	0	13512	1290	45	2	44	2	RNF145	5	158585719	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4825698	158585719	22329541	221	39111											
RARS	5917	broad.mit.edu	37	chr5	167922356	167922356	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcccctaatatagctaaaGagatgcatgtaggccacctg	12	9	8	12	0	0	1	0	0	0	1	1	2	1	1	5	1	2	3	5	1	6	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:167922356G>C	uc003lzx.2	+	6	657	c.616G>C	c.(616-618)GAG>CAG	p.E206Q	RARS_uc011deo.1_5'UTR	NM_002887	NP_002878	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	206	HIGH region.				arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|skin(1)	3	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		TATAGCTAAAGAGATGCATGT	0.428													3	161					0	0	0	0	C	167922356	C	C	167922356	3	2	214	1	0	0	0	0	1	0	0	0	13123	943	33	2	638	2	RARS	5	167922356	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9336637	167922356	12992904	222	39112											
NSD1	64324	broad.mit.edu	37	chr5	176562391	176562391	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtctgctgatggatcagaatCctttcaagaccctgaaaaaa	14	10	8	9	0	3	4	2	2	1	2	4	5	4	5	2	1	1	1	2	1	5	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:176562391C>G	uc003mfr.3	+	2	425	c.287C>G	c.(286-288)TCC>TGC	p.S96C	NSD1_uc003mft.3_Intron|NSD1_uc003mfs.1_Missense_Mutation_p.S96C|NSD1_uc011dfx.1_Intron|NSD1_uc003mfp.2_Missense_Mutation_p.S96C|NSD1_uc003mfq.2_Missense_Mutation_p.S96C	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	96					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GGATCAGAATCCTTTCAAGAC	0.438			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			12	47					0	0	0	0	G	176562391	G	G	176562391	3	3	214	1	0	0	0	0	1	0	0	0	10723	855	30	2	289	2	NSD1	5	176562391	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	8640035	176562391	4352869	223	39113											
ZFP2	80108	broad.mit.edu	37	chr5	178358777	178358777	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaaagaattcatactggaGagaaaccctataaatgtaat	19	10	6	6	0	2	2	2	0	0	2	2	4	2	3	1	1	2	1	1	1	8	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:178358777G>C	uc003mjn.1	+	5	972	c.463G>C	c.(463-465)GAG>CAG	p.E155Q	ZFP2_uc010jky.2_Missense_Mutation_p.E155Q|ZFP2_uc010jkx.1_Missense_Mutation_p.E155Q	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		TCATACTGGAGAGAAACCCTA	0.413													17	52					0	0	0	0	C	178358777	C	C	178358777	3	2	214	1	0	0	0	0	1	0	0	0	17708	943	33	2	465	2	ZFP2	5	178358777	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1796386	178358777	2556483	224	39114											
ZNF354C	30832	broad.mit.edu	37	chr5	178507032	178507032	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggaatatgggaaacctttCatctgcagctcctcacttac	12	11	7	11	0	3	0	2	0	1	0	4	2	4	2	2	2	4	2	2	2	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr5:178507032C>T	uc003mju.2	+	5	1714	c.1599C>T	c.(1597-1599)TTC>TTT	p.F533F		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	533					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		GGAAACCTTTCATCTGCAGCT	0.383													19	84					0	0	0	0	T	178507032	T	T	178507032	2	4	214	1	0	0	0	0	0	0	0	1	17933	825	29	2		2	ZNF354C	5	178507032	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	148255	178507032	2408228	225	39115											
RIPK1	8737	broad.mit.edu	37	chr6	3081283	3081283	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aggaatgtgctacttacatgGaaaaggcgtgatacacaagg	15	8	12	6	1	0	1	0	1	0	0	0	3	0	3	0	4	4	1	0	4	7	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:3081283G>C	uc010jni.2	+	4	624	c.392G>C	c.(391-393)GGA>GCA	p.G131A	RIPK1_uc003muv.3_5'UTR|RIPK1_uc003muw.3_Missense_Mutation_p.G66A|RIPK1_uc011dhs.1_Intron|RIPK1_uc003mux.2_Missense_Mutation_p.G131A	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	131	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TACTTACATGGAAAAGGCGTG	0.368													13	42					0	0	0	0	C	3081283	C	C	3081283	3	2	214	1	0	0	0	0	1	0	0	0	13445	1174	41	2	402	2	RIPK1	6	3081283	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08		3081283	168033784	226	39116											
HIVEP1	3096	broad.mit.edu	37	chr6	12122774	12122774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagtcatgttcttggtactGgacagtccctggatgagagc	10	11	12	8	0	2	1	1	1	1	1	3	4	3	3	1	3	2	2	1	3	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:12122774G>A	uc003nac.2	+	4	2925	c.2746G>A	c.(2746-2748)GGA>AGA	p.G916R	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	916					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding	p.G916R(1)		ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TCTTGGTACTGGACAGTCCCT	0.517													12	47					0	0	0	0	A	12122774	A	A	12122774	3	1	214	1	0	0	0	0	1	0	0	0	7225	1349	47	4	2756	4	HIVEP1	6	12122774	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9041491	12122774	158992293	227	39117											
MYLIP	29116	broad.mit.edu	37	chr6	16141928	16141928	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttccccagagcaggcagtGgaactcagtgccctcctggc	7	8	12	14	0	1	1	1	0	0	1	3	2	3	2	4	3	3	3	4	3	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:16141928G>T	uc003nbq.2	+	3	588	c.351G>T	c.(349-351)GTG>GTT	p.V117V	MYLIP_uc003nbr.2_5'UTR	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	117	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			AGCAGGCAGTGGAACTCAGTG	0.527													9	70					3.09899e-07	3.26537e-07	1	0	T	16141928	T	T	16141928	2	4	214	1	0	0	0	0	0	0	0	1	10108	1335	47	4		4	MYLIP	6	16141928	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4019154	16141928	154973139	228	39118											
PGBD1	84547	broad.mit.edu	37	chr6	28251866	28251866	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgctggtgctggagcagttCctgaccatcctgcccaagga	7	9	12	13	0	0	1	0	1	0	0	2	3	2	3	4	3	4	4	4	3	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:28251866C>G	uc003nky.2	+	2	646	c.276C>G	c.(274-276)TTC>TTG	p.F92L	PGBD1_uc003nkz.2_Missense_Mutation_p.F92L	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	92	SCAN box.				viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						TGGAGCAGTTCCTGACCATCC	0.537													26	74					0	0	0	0	G	28251866	G	G	28251866	3	3	214	1	0	0	0	0	1	0	0	0	11835	854	30	2	278	2	PGBD1	6	28251866	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	12109938	28251866	142863201	229	39119											
TRIM39	56658	broad.mit.edu	37	chr6	30297129	30297129	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgttagaggctggggcctCtgcagcctctacagctgcgg	5	10	14	12	1	3	1	0	0	3	1	3	1	3	1	2	4	5	4	2	4	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:30297129C>T	uc010jrz.2	+	3	347	c.35C>T	c.(34-36)TCT>TTT	p.S12F	HCG18_uc003npw.2_5'Flank|HCG18_uc003npx.2_5'Flank|HCG18_uc003npy.2_5'Flank|TRIM39_uc003npz.2_Missense_Mutation_p.S12F|TRIM39_uc003nqb.2_Missense_Mutation_p.S12F|TRIM39_uc003nqc.2_Missense_Mutation_p.S12F|TRIM39_uc010jsa.1_Missense_Mutation_p.S12F	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	12					apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						GCTGGGGCCTCTGCAGCCTCT	0.473													50	149					0	0	0	0	T	30297129	T	T	30297129	3	4	214	1	0	0	0	0	1	0	0	0	16580	913	32	2	37	2	TRIM39	6	30297129	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2045263	30297129	140817938	230	39120											
KIAA1949	170954	broad.mit.edu	37	chr6	30647097	30647097	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aggctccgggcccagctcctCcagtaccgaactctcggagg	7	6	12	16	3	1	0	0	0	1	0	5	2	4	1	5	4	3	3	5	4	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:30647097C>G	uc003nra.2	-	3	1912	c.1681G>C	c.(1681-1683)GAG>CAG	p.E561Q	KIAA1949_uc003nrb.3_Missense_Mutation_p.E561Q	NM_001134870	NP_001128342	Q6NYC8	PHTNS_HUMAN	phostensin	561						cytoplasm|cytoskeleton	actin binding				0						CCCAGCTCCTCCAGTACCGAA	0.627													24	46					0	0	0	0	G	30647097	G	G	30647097	3	3	214	1	0	0	0	0	1	0	0	0	8302	864	30	2	168	2	KIAA1949	6	30647097	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	349968	30647097	140467970	231	39121											
FKBPL	63943	broad.mit.edu	37	chr6	32097143	32097143	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttagctctgtccagccctCtggcggccctgatccgaaag	7	9	11	14	2	2	1	0	1	2	0	4	2	4	1	4	2	2	2	4	2	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:32097143C>T	uc003nzr.2	-	2	685	c.415G>A	c.(415-417)GAG>AAG	p.E139K	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	139					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						GTCCAGCCCTCTGGCGGCCCT	0.562													85	228					0	0	0	0	T	32097143	T	T	32097143	3	4	214	1	0	0	0	0	1	0	0	0	5948	922	32	2	638	2	FKBPL	6	32097143	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1450046	32097143	139017924	232	39122											
FKBPL	63943	broad.mit.edu	37	chr6	32097257	32097257	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcttgacaaagctcccatCggggcagtaccagagatcag	11	8	10	12	1	2	2	1	1	1	1	4	3	3	2	2	2	2	3	2	2	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:32097257C>A	uc003nzr.2	-	2	571	c.301G>T	c.(301-303)GAT>TAT	p.D101Y	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	101					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						AAGCTCCCATCGGGGCAGTAC	0.517													21	84					1.01871e-10	1.09397e-10	1	0	A	32097257	A	A	32097257	3	1	214	1	0	0	0	0	1	0	0	0	5948	884	31	3	752	3	FKBPL	6	32097257	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	114	32097257	139017810	233	39123											
PRRT1	80863	broad.mit.edu	37	chr6	32118683	32118683	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagggactgagtctgggagtCctgggggaggtgagtggagg	7	7	23	4	0	1	2	0	2	1	0	2	7	2	6	1	7	0	0	1	7	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:32118683C>T	uc003nzt.2	-	2	136	c.20G>A	c.(19-21)GGA>GAA	p.G7E	PRRT1_uc003nzs.2_Missense_Mutation_p.G48E|PRRT1_uc003nzu.2_Intron|PPT2_uc003nzw.2_5'Flank|PPT2_uc003nzx.2_5'Flank|PPT2_uc011dpi.1_5'Flank|PPT2_uc003nzy.1_5'Flank	NM_030651	NP_085154	Q99946	PRRT1_HUMAN	NG5 protein	7					response to biotic stimulus	integral to membrane				breast(1)	1						GTCTGGGAGTCCTGGGGGAGG	0.607													5	11					0	0	0	0	T	32118683	T	T	32118683	3	4	214	1	0	0	0	0	1	0	0	0	12671	869	30	2	912	2	PRRT1	6	32118683	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	21426	32118683	138996384	234	39124											
SLC39A7	7922	broad.mit.edu	37	chr6	33169037	33169037	+	Frame_Shift_Del	DEL	G	-	-																															agcgtgatggccagaggcctGggggccccccactgggtggc																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:33169037delG	uc003odf.2	+	2	132	c.15delG	c.(13-15)CTGfs	p.L5fs	RXRB_uc003odb.2_5'Flank|RXRB_uc003odc.2_5'Flank|RXRB_uc003odd.2_5'Flank|RXRB_uc011dqr.1_5'Flank|RXRB_uc011dqs.1_5'Flank|RXRB_uc003ode.1_5'Flank|RXRB_uc011dqt.1_5'Flank|RXRB_uc011dqu.1_5'Flank|SLC39A7_uc003odg.2_Frame_Shift_Del_p.L5fs|SLC39A7_uc011dqv.1_5'UTR|SLC39A7_uc003odh.2_5'Flank	NM_001077516	NP_001070984	Q92504	S39A7_HUMAN	solute carrier family 39, member 7	5						endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			large_intestine(1)	1						CCAGAGGCCTGGGGGCCCCCC	0.637													---	---	---								-	33169037	-	-	33169037	7	5	214	1	0	1	0	1	0	0	0	0	14687	1335	47	0	17	0	SLC39A7	6	33169037	Frame_Shift_Del	DEL	G	TCGA-CV-6961-01A-21D-1912-08	1050354	33169037	137946030	235	39125											
ITPR3	3710	broad.mit.edu	37	chr6	33656530	33656530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacatcatcattgccttcttCtacccttacatggagggcgc	9	12	7	13	1	4	0	2	0	2	0	4	1	4	1	2	2	4	0	2	2	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:33656530C>G	uc011drk.1	+	49	6885	c.6666C>G	c.(6664-6666)TTC>TTG	p.F2222L	ITPR3_uc003oey.2_Missense_Mutation_p.F309L	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2222	Helical; (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TTGCCTTCTTCTACCCTTACA	0.612													18	68					0	0	0	0	G	33656530	G	G	33656530	3	3	214	1	0	0	0	0	1	0	0	0	7961	912	32	2	6860	2	ITPR3	6	33656530	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	487493	33656530	137458537	236	39126											
UHRF1BP1	54887	broad.mit.edu	37	chr6	34839418	34839419	+	Frame_Shift_Ins	INS	-	T	T																															catccccatcactctggccaINStggaacatgttgtgctgaag																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:34839418_34839419insT	uc003oju.3	+	19	4273_4274	c.4039_4040insT	c.(4039-4041)ATGfs	p.M1347fs	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1347										ovary(3)	3						CACTCTGGCCATGGAACATGTT	0.525													---	---	---								T	34839419	T	T	34839418	7	5	214	1	0	1	1	0	0	0	0	0	17036	217	8	0	4113	0	UHRF1BP1	6	34839418	Frame_Shift_Ins	INS	-	TCGA-CV-6961-01A-21D-1912-08	1182888	34839418	136275649	237	39127											
ZNF76	7629	broad.mit.edu	37	chr6	35260660	35260660	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggctctcctctcccagccGcctctgcagccgaggagagt	5	9	11	16	2	3	1	0	0	3	1	5	3	3	1	5	2	3	2	5	2	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:35260660G>T	uc003oki.1	+	11	1373	c.1168G>T	c.(1168-1170)GCC>TCC	p.A390S	ZNF76_uc003okj.1_Missense_Mutation_p.A390S	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	390					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCTCCCAGCCGCCTCTGCAGC	0.617													9	88					2.74318e-10	2.9418e-10	1	0	T	35260660	T	T	35260660	3	4	214	1	0	0	0	0	1	0	0	0	18202	1087	38	3	1206	3	ZNF76	6	35260660	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	421242	35260660	135854407	238	39128											
C6orf222	389384	broad.mit.edu	37	chr6	36285134	36285134	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagtgcaagacacagctttCaatctggactttcaacctta	12	12	7	10	0	3	2	2	1	1	1	3	3	3	3	1	1	3	2	1	1	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:36285134C>T	uc003oly.2	-	12	2136	c.1958G>A	c.(1957-1959)TGA>TAA	p.*653*		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	653										skin(2)|ovary(1)|breast(1)	4						ACACAGCTTTCAATCTGGACT	0.443													19	37					0	0	0	0	T	36285134	T	T	36285134	2	4	214	1	0	0	0	0	0	0	0	1	2366	837	29	2		2	C6orf222	6	36285134	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1024474	36285134	134829933	239	39129											
GSTA3	2940	broad.mit.edu	37	chr6	52767169	52767169	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctcctttatgtctttccCgtagaggttgtatttgctgg	4	19	9	9	1	2	1	0	0	2	1	5	1	4	1	2	2	1	4	2	2	3	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:52767169C>T	uc003pbb.2	-	4	326	c.247G>A	c.(247-249)GGG>AGG	p.G83R	GSTA3_uc010jzq.2_Missense_Mutation_p.G27R	NM_000847	NP_000838	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	83	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity				0	Lung NSC(77;0.0912)				Glutathione(DB00143)	ATGTCTTTCCCGTAGAGGTTG	0.448													50	147					0	0	0	0	T	52767169	T	T	52767169	3	4	214	1	0	0	0	0	1	0	0	0	6871	652	23	1	437	1	GSTA3	6	52767169	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	16482035	52767169	118347898	240	39130											
SNAP91	9892	broad.mit.edu	37	chr6	84311158	84311158	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaagtgcagccaaagaatCtatatttcaccagagacaga	17	7	9	8	0	2	3	1	0	1	3	2	5	2	4	2	1	2	1	2	1	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:84311158C>G	uc011dze.1	-	15	1474	c.1157_splice	c.e15-1	p.D386_splice	SNAP91_uc011dzd.1_Splice_Site|SNAP91_uc003pkb.2_Splice_Site_p.D349_splice|SNAP91_uc003pkc.2_Splice_Site_p.D384_splice|SNAP91_uc003pkd.2_Intron|SNAP91_uc003pka.2_Splice_Site_p.D384_splice	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog						clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		GCCAAAGAATCTATATTTCAC	0.413													5	40					0	0	0	0	G	84311158	G	G	84311158	5	3	214	1	0	0	0	0	0	0	1	0	14897	927	32	2	1623	2	SNAP91	6	84311158	Splice_Site	SNP	C	TCGA-CV-6961-01A-21D-1912-08	31543989	84311158	86803909	241	39131											
CNR1	1268	broad.mit.edu	37	chr6	88854153	88854153	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcagtacgctggtgacccCgatccagaacatcaggtagg	12	6	12	11	2	1	2	1	1	0	1	2	3	2	2	3	3	3	4	3	3	4	2	rs140051374		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:88854153C>A	uc011dzq.1	-	2	4404	c.841G>T	c.(841-843)GGG>TGG	p.G281W	CNR1_uc010kbz.2_Missense_Mutation_p.G281W|CNR1_uc011dzr.1_Missense_Mutation_p.G281W|CNR1_uc011dzs.1_Missense_Mutation_p.G281W|CNR1_uc003pmq.3_Missense_Mutation_p.G281W|CNR1_uc011dzt.1_Missense_Mutation_p.G281W|CNR1_uc010kca.2_Missense_Mutation_p.G248W	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	281	Helical; Name=5; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	CTGGTGACCCCGATCCAGAAC	0.532													4	74					0.00909568	0.00929702	1	0	A	88854153	A	A	88854153	3	1	214	1	0	0	0	0	1	0	0	0	3646	652	23	3	581	3	CNR1	6	88854153	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4542995	88854153	82260914	242	39132											
MDN1	23195	broad.mit.edu	37	chr6	90402813	90402813	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggggtctaaaggcctgtttCttcaacaggtgacaggttaa	10	12	12	7	0	3	1	1	1	2	0	3	1	3	1	1	5	1	2	1	5	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:90402813C>T	uc003pnn.1	-	63	10052	c.9936G>A	c.(9934-9936)AAG>AAA	p.K3312K		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3312					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGGCCTGTTTCTTCAACAGGT	0.512													14	35					0	0	0	0	T	90402813	T	T	90402813	2	4	214	1	0	0	0	0	0	0	0	1	9468	912	32	2		2	MDN1	6	90402813	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1548660	90402813	80712254	243	39133											
BACH2	60468	broad.mit.edu	37	chr6	90648025	90648025	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atcatcatctggaaatcgttCcttggaagatctgtgatttg	10	15	9	7	1	4	2	2	1	2	1	6	4	5	4	1	2	0	1	1	2	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:90648025C>A	uc011eab.1	-	8	2690	c.1881G>T	c.(1879-1881)AGG>AGT	p.R627S	BACH2_uc003pnw.2_Missense_Mutation_p.R627S	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	627						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		GGAAATCGTTCCTTGGAAGAT	0.423													18	43					3.51602e-12	3.807e-12	1	0	A	90648025	A	A	90648025	3	1	214	1	0	0	0	0	1	0	0	0	1286	854	30	2	652	2	BACH2	6	90648025	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	245212	90648025	80467042	244	39134											
ARMC2	84071	broad.mit.edu	37	chr6	109285456	109285456	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgcctgtggtgttctcctCaatctcactgtggataaaga	8	14	9	10	0	4	1	2	0	3	1	6	2	4	2	2	2	1	1	2	2	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:109285456C>T	uc003pss.3	+	16	2400	c.2226C>T	c.(2224-2226)CTC>CTT	p.L742L	ARMC2_uc011eao.1_Silent_p.L577L	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	742	ARM 11.						binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		GTGTTCTCCTCAATCTCACTG	0.473													9	25					0	0	0	0	T	109285456	T	T	109285456	2	4	214	1	0	0	0	0	0	0	0	1	953	813	29	2		2	ARMC2	6	109285456	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	18637431	109285456	61829611	245	39135											
ZBTB24	9841	broad.mit.edu	37	chr6	109788881	109788881	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattctgatgtgggtctgaaGagaactctttgctgtgaaag	10	13	13	5	0	3	4	0	3	3	1	3	6	3	4	0	1	2	1	0	1	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:109788881G>A	uc003ptl.1	-	6	1513	c.1345C>T	c.(1345-1347)CTT>TTT	p.L449F	MICAL1_uc011eaq.1_5'Flank|ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.L393F|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	449	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		TGGGTCTGAAGAGAACTCTTT	0.338													4	23					0	0	0	0	A	109788881	A	A	109788881	3	1	214	1	0	0	0	0	1	0	0	0	17598	942	33	2	756	2	ZBTB24	6	109788881	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	503425	109788881	61326186	246	39136											
RSPH4A	345895	broad.mit.edu	37	chr6	116938309	116938309	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataacaacgctaaacagaaaGagctgagatttgacgttttt	16	11	8	6	2	0	4	0	2	0	3	0	5	0	4	0	0	4	3	0	0	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:116938309G>A	uc003pxe.2	+	1	668	c.523G>A	c.(523-525)GAG>AAG	p.E175K	RSPH4A_uc010kee.2_Missense_Mutation_p.E175K	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	175					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						TAAACAGAAAGAGCTGAGATT	0.512									Kartagener_syndrome				33	116					0	0	0	0	A	116938309	A	A	116938309	3	1	214	1	0	0	0	0	1	0	0	0	13771	943	33	2	525	2	RSPH4A	6	116938309	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	7149428	116938309	54176758	247	39137											
HIVEP2	3097	broad.mit.edu	37	chr6	143091557	143091557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tactggctggagaaagcattCgcttgctacctcccagggtg	8	10	12	11	1	0	1	0	0	0	1	2	2	1	1	2	3	4	4	2	3	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:143091557C>T	uc003qjd.2	-	5	5062	c.4319G>A	c.(4318-4320)CGA>CAA	p.R1440Q		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AGAAAGCATTCGCTTGCTACC	0.517													23	57					0	0	0	0	T	143091557	T	T	143091557	3	4	214	1	0	0	0	0	1	0	0	0	7226	884	31	1	3045	1	HIVEP2	6	143091557	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	26153248	143091557	28023510	248	39138											
IGF2R	3482	broad.mit.edu	37	chr6	160484469	160484469	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacaactgtgaggtgaaagaCccaaggcatggcaacttgta	14	7	12	8	0	0	3	0	2	0	1	0	4	0	3	1	3	2	3	1	3	5	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:160484469C>G	uc003qta.2	+	27	3841	c.3693C>G	c.(3691-3693)GAC>GAG	p.D1231E		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1231	8.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		AGGTGAAAGACCCAAGGCATG	0.493													13	74					0	0	0	0	G	160484469	G	G	160484469	3	3	214	1	0	0	0	0	1	0	0	0	7615	506	18	4	3799	4	IGF2R	6	160484469	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	17392912	160484469	10630598	249	39139											
PLG	5340	broad.mit.edu	37	chr6	161134112	161134112	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccctggtgctatactactGatccagaaaagagatatgac	13	9	10	9	0	0	4	0	2	0	2	1	5	1	4	2	2	3	1	2	2	6	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr6:161134112G>C	uc003qtm.3	+	5	565	c.502G>C	c.(502-504)GAT>CAT	p.D168H		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	168	Kringle 1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CTATACTACTGATCCAGAAAA	0.478													24	143					0	0	0	0	C	161134112	C	C	161134112	3	2	214	1	0	0	0	0	1	0	0	0	12141	1290	45	2	524	2	PLG	6	161134112	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	649643	161134112	9980955	250	39140											
SDK1	221935	broad.mit.edu	37	chr7	4213926	4213926	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagggagctggagtatgaaGccgggtcaggcactgaggcc	10	5	17	9	1	1	2	1	2	0	0	1	4	1	4	2	5	2	3	2	5	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:4213926G>T	uc003smx.2	+	33	5012	c.4873G>T	c.(4873-4875)GCC>TCC	p.A1625S	SDK1_uc010kso.2_Missense_Mutation_p.A901S|SDK1_uc003smy.2_Missense_Mutation_p.A112S	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1625	Fibronectin type-III 10.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGAGTATGAAGCCGGGTCAGG	0.552													42	256					1.38658e-30	1.54173e-30	1	0	T	4213926	T	T	4213926	3	4	214	1	0	0	0	0	1	0	0	0	14033	971	34	4	5003	4	SDK1	7	4213926	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08		4213926	154924737	251	39141											
RSPH10B2	728194	broad.mit.edu	37	chr7	5967846	5967846	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttgcttccagttcgtcatCttccatcttccgctgctggg	3	15	8	15	2	3	0	1	0	2	0	7	0	6	0	4	1	2	4	4	1	0	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:5967846C>T	uc003sph.1	-	20	2684	c.2413G>A	c.(2413-2415)GAT>AAT	p.D805N	RSPH10B2_uc003spg.1_Silent_p.K606K|RSPH10B2_uc010ktd.1_Missense_Mutation_p.D805N|RSPH10B2_uc011jwk.1_3'UTR	NM_173565	NP_775836	B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B	805	Potential.									ovary(1)|pancreas(1)|skin(1)	3						AGTTCGTCATCTTCCATCTTC	0.522													46	253					0	0	0	0	T	5967846	T	T	5967846	3	4	214	1	0	0	0	0	1	0	0	0	13769	913	32	2	207	2	RSPH10B2	7	5967846	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1753920	5967846	153170817	252	39142											
DGKB	1607	broad.mit.edu	37	chr7	14613864	14613864	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggaaaagtaattattgatGatactgtaaggcactgggtc	14	12	11	4	0	0	2	0	2	0	0	1	3	0	3	0	3	1	3	0	3	6	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:14613864G>A	uc003ssz.2	-	19	1933	c.1746C>T	c.(1744-1746)ATC>ATT	p.I582I	DGKB_uc011jxt.1_Silent_p.I563I|DGKB_uc003sta.2_Silent_p.I582I|DGKB_uc011jxu.1_Silent_p.I581I	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	582					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	AATTATTGATGATACTGTAAG	0.358													4	160					0	0	0	0	A	14613864	A	A	14613864	2	1	214	1	0	0	0	0	0	0	0	1	4488	1280	45	2		2	DGKB	7	14613864	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	8646018	14613864	144524799	253	39143											
TWIST1	7291	broad.mit.edu	37	chr7	19156446	19156446	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccatcttggagtccagctCgtcgctctggaggacctggt	5	11	13	12	2	2	0	0	0	2	0	5	3	3	3	3	4	2	2	3	4	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:19156446C>A	uc003sum.2	-	1	850	c.499G>T	c.(499-501)GAG>TAG	p.E167*		NM_000474	NP_000465	Q15672	TWST1_HUMAN	twist	167	Sufficient for transactivation activity (By similarity).				aortic valve morphogenesis|cellular response to hypoxia|embryonic camera-type eye formation|embryonic cranial skeleton morphogenesis|eyelid development in camera-type eye|muscle organ development|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of histone phosphorylation|negative regulation of osteoblast differentiation|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of cell motility|positive regulation of epithelial to mesenchymal transition|positive regulation of fatty acid beta-oxidation|positive regulation of monocyte chemotactic protein-1 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of tumor necrosis factor production|regulation of bone mineralization	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding RNA polymerase II transcription factor activity				0						GAGTCCAGCTCGTCGCTCTGG	0.617									Saethre-Chotzen_syndrome				9	18					1.58986e-06	1.66628e-06	1	0	A	19156446	A	A	19156446	4	1	214	1	0	0	0	0	0	1	0	0	16851	893	31	3	113	3	TWIST1	7	19156446	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4542582	19156446	139982217	254	39144											
ABCB5	340273	broad.mit.edu	37	chr7	20739704	20739704	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttattttacggcagagcaggGgaaattttaacgatgagatt	13	13	11	4	2	0	2	0	1	0	2	0	5	0	3	0	3	3	2	0	3	4	6	rs148327292		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:20739704G>T	uc003suw.3	+	10	1494	c.948G>T	c.(946-948)GGG>GGT	p.G316G	ABCB5_uc010kuh.2_Silent_p.G761G	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	316	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						GCAGAGCAGGGGAAATTTTAA	0.284													12	39					0.00244969	0.00251703	1	0	T	20739704	T	T	20739704	2	4	214	1	0	0	0	0	0	0	0	1	44	1219	43	4		4	ABCB5	7	20739704	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1583258	20739704	138398959	255	39145											
DNAH11	8701	broad.mit.edu	37	chr7	21621571	21621571	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtccaaaactctggaatttGacagaaggcttgggacaatt	14	10	10	7	0	1	2	0	1	1	1	2	4	2	4	1	3	1	1	1	3	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:21621571G>C	uc003svc.2	+	9	1673	c.1642G>C	c.(1642-1644)GAC>CAC	p.D548H		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	548	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCTGGAATTTGACAGAAGGCT	0.333									Kartagener_syndrome				3	92					0	0	0	0	C	21621571	C	C	21621571	3	2	214	1	0	0	0	0	1	0	0	0	4621	1290	45	2	1676	2	DNAH11	7	21621571	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	881867	21621571	137517092	256	39146											
DNAH11	8701	broad.mit.edu	37	chr7	21639530	21639530	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacgacttagacttctttctGaagaatacagagaaacaatt	16	11	6	8	1	2	4	0	1	2	3	2	6	2	4	0	0	2	0	0	0	6	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:21639530G>A	uc003svc.2	+	15	2824	c.2793G>A	c.(2791-2793)CTG>CTA	p.L931L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	931	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ACTTCTTTCTGAAGAATACAG	0.403									Kartagener_syndrome				13	16					0	0	0	0	A	21639530	A	A	21639530	2	1	214	1	0	0	0	0	0	0	0	1	4621	1277	45	2		2	DNAH11	7	21639530	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	17959	21639530	137499133	257	39147											
NT5C3	51251	broad.mit.edu	37	chr7	33060909	33060909	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccatataagggtacttctCttctacagtaagaacaggat	14	11	7	9	0	2	1	0	0	2	1	3	2	2	2	1	2	3	2	1	2	6	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:33060909C>G	uc003tdk.2	-	5	507	c.430G>C	c.(430-432)GAG>CAG	p.E144Q	AVL9_uc011kai.1_Intron|NT5C3_uc003tdi.2_Missense_Mutation_p.E105Q|NT5C3_uc003tdj.2_Missense_Mutation_p.E105Q	NM_001002010	NP_001002010	Q9H0P0	5NT3_HUMAN	5'-nucleotidase, cytosolic III isoform 1	144				E -> Q (in Ref. 11; AA sequence).	nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1			GBM - Glioblastoma multiforme(11;0.0894)			GGGTACTTCTCTTCTACAGTA	0.313													19	68					0	0	0	0	G	33060909	G	G	33060909	3	3	214	1	0	0	0	0	1	0	0	0	10742	922	32	2	600	2	NT5C3	7	33060909	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	11421379	33060909	126077754	258	39148											
NPC1L1	29881	broad.mit.edu	37	chr7	44578910	44578910	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgctgccaaggccaccacCgggatgacagatagcaccaa	12	3	10	16	2	0	2	0	1	0	1	0	3	0	3	6	2	2	2	6	2	3	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:44578910C>T	uc003tlb.2	-	2	1142	c.1086G>A	c.(1084-1086)CCG>CCA	p.P362P	NPC1L1_uc003tlc.2_Silent_p.P362P|NPC1L1_uc011kbw.1_Silent_p.P362P|NPC1L1_uc003tld.2_Silent_p.P362P	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	362	Helical; Name=2; (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	AGGCCACCACCGGGATGACAG	0.622													34	101					0	0	0	0	T	44578910	T	T	44578910	2	4	214	1	0	0	0	0	0	0	0	1	10625	639	23	1		1	NPC1L1	7	44578910	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	11518001	44578910	114559753	259	39149											
POM121L12	285877	broad.mit.edu	37	chr7	53103789	53103789	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggtgaccatcgggatcgCgccccctgagcgtcaggaga	7	5	14	15	5	1	3	1	2	0	1	3	5	1	4	4	3	1	0	4	3	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:53103789C>T	uc003tpz.2	+	1	441	c.425C>T	c.(424-426)GCG>GTG	p.A142V		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	142											0						ATCGGGATCGCGCCCCCTGAG	0.587													13	30					0	0	0	0	T	53103789	T	T	53103789	3	4	214	1	0	0	0	0	1	0	0	0	12296	768	27	1	427	1	POM121L12	7	53103789	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	8524879	53103789	106034874	260	39150											
EGFR	1956	broad.mit.edu	37	chr7	55224337	55224337	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcgatctccacatcctgcCggtggcatttagggggtgag	6	10	15	10	2	1	1	0	1	1	0	3	2	2	1	3	5	1	1	3	5	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:55224337C>A	uc003tqk.2	+	9	1364	c.1118C>A	c.(1117-1119)CCG>CAG	p.P373Q	EGFR_uc003tqh.2_Missense_Mutation_p.P373Q|EGFR_uc003tqi.2_Missense_Mutation_p.P373Q|EGFR_uc003tqj.2_Missense_Mutation_p.P373Q|EGFR_uc010kzg.1_Missense_Mutation_p.P328Q|EGFR_uc011kco.1_Missense_Mutation_p.P320Q|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	373	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CACATCCTGCCGGTGGCATTT	0.403		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			13	57					1.3612e-06	1.42854e-06	1	0	A	55224337	A	A	55224337	3	1	214	1	0	0	0	0	1	0	0	0	4989	652	23	3	1152	3	EGFR	7	55224337	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2120548	55224337	103914326	261	39151											
SUMF2	25870	broad.mit.edu	37	chr7	56142396	56142396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacgactgcccacggaggaaGagtgggagtttgccgcccga	10	5	15	11	4	0	1	0	0	0	1	0	6	0	4	3	3	3	1	3	3	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:56142396G>A	uc003trv.2	+	5	590	c.559G>A	c.(559-561)GAG>AAG	p.E187K	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_Intron|SUMF2_uc011kcw.1_Missense_Mutation_p.E187K|SUMF2_uc011kcx.1_Intron|SUMF2_uc003trt.2_Missense_Mutation_p.E80K|SUMF2_uc011kcy.1_Missense_Mutation_p.E172K|SUMF2_uc011kcz.1_Intron|SUMF2_uc003tru.2_Intron|SUMF2_uc011kda.1_Intron|SUMF2_uc003trx.2_Intron	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	168						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CACGGAGGAAGAGTGGGAGTT	0.567											OREG0018081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	112					0	0	0	0	A	56142396	A	A	56142396	3	1	214	1	0	0	0	0	1	0	0	0	15452	943	33	2	577	2	SUMF2	7	56142396	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	918059	56142396	102996267	262	39152											
ZNF107	51427	broad.mit.edu	37	chr7	64168926	64168927	+	Frame_Shift_Ins	INS	-	A	A																															atactggagagaaaccctacINSaaatgtggagattatggcag																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:64168926_64168927insA	uc003ttd.2	+	7	3030_3031	c.2244_2245insA	c.(2242-2247)TACAAAfs	p.Y748fs	ZNF107_uc003tte.2_Frame_Shift_Ins_p.Y748fs	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	748_749	C2H2-type 25; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AGAAACCCTACAAATGTGGAGA	0.361													---	---	---								A	64168927	A	A	64168926	7	5	214	1	0	1	1	0	0	0	0	0	17782	489	17	0	2250	0	ZNF107	7	64168926	Frame_Shift_Ins	INS	-	TCGA-CV-6961-01A-21D-1912-08	8026530	64168926	94969737	263	39153											
LIMK1	3984	broad.mit.edu	37	chr7	73520530	73520530	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgagctctccggcttatactCccagcggggaggcgggcagc	6	7	15	13	3	1	1	0	1	1	0	3	2	2	2	2	5	4	3	2	5	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:73520530C>T	uc003uaa.1	+	7	1003	c.838C>T	c.(838-840)CCC>TCC	p.P280S	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.P246S|LIMK1_uc003uac.1_Missense_Mutation_p.P72S	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	280					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				GGCTTATACTCCCAGCGGGGA	0.657													36	176					0	0	0	0	T	73520530	T	T	73520530	3	4	214	1	0	0	0	0	1	0	0	0	8842	855	30	2	864	2	LIMK1	7	73520530	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	9351604	73520530	85618133	264	39154											
LIMK1	3984	broad.mit.edu	37	chr7	73521420	73521420	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgcaaggacctgggtcgctCtgagtccctccgcgtagtct	5	9	13	14	4	2	1	0	1	2	0	5	2	4	2	3	2	0	3	3	2	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:73521420C>G	uc003uaa.1	+	8	1127	c.962C>G	c.(961-963)TCT>TGT	p.S321C	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.S287C|LIMK1_uc003uac.1_Missense_Mutation_p.S113C	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	321					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				CTGGGTCGCTCTGAGTCCCTC	0.697													3	18					0	0	0	0	G	73521420	G	G	73521420	3	3	214	1	0	0	0	0	1	0	0	0	8842	913	32	2	992	2	LIMK1	7	73521420	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	890	73521420	85617243	265	39155											
CACNA2D1	781	broad.mit.edu	37	chr7	81662153	81662153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttaaatatctcctgggctCtctcttctcctccatccgtg	5	16	6	14	1	4	0	0	0	4	0	9	0	6	0	4	1	0	2	4	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:81662153C>T	uc003uhr.1	-	12	1359	c.1103G>A	c.(1102-1104)AGA>AAA	p.R368K		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	368	Extracellular (Potential).|VWFA.					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTCCTGGGCTCTCTCTTCTCC	0.279													13	24					0	0	0	0	T	81662153	T	T	81662153	3	4	214	1	0	0	0	0	1	0	0	0	2560	913	32	2	2284	2	CACNA2D1	7	81662153	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	8140733	81662153	77476510	266	39156											
STEAP4	79689	broad.mit.edu	37	chr7	87913538	87913538	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atacagtctcttgcttttctGaagaattcatagtaagagga	13	14	8	6	0	3	3	1	1	2	2	4	4	3	4	0	1	2	2	0	1	5	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:87913538G>A	uc003ujs.2	-	2	152	c.47C>T	c.(46-48)TCA>TTA	p.S16L	STEAP4_uc010lek.2_Missense_Mutation_p.S16L|STEAP4_uc003ujt.2_Missense_Mutation_p.S16L	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	16					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					TTGCTTTTCTGAAGAATTCAT	0.353													10	34					0	0	0	0	A	87913538	A	A	87913538	3	1	214	1	0	0	0	0	1	0	0	0	15346	1294	45	2	1348	2	STEAP4	7	87913538	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6251385	87913538	71225125	267	39157											
NPTX2	4885	broad.mit.edu	37	chr7	98256620	98256620	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggccccctggcaccccatCaagcccgggggcgtgctgat	5	6	13	17	2	1	1	1	1	0	0	1	1	1	1	5	4	2	2	5	4	1	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:98256620C>G	uc003upl.2	+	4	1209	c.1032C>G	c.(1030-1032)ATC>ATG	p.I344M		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	344	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GGCACCCCATCAAGCCCGGGG	0.662													16	40					0	0	0	0	G	98256620	G	G	98256620	3	3	214	1	0	0	0	0	1	0	0	0	10657	816	29	2	1046	2	NPTX2	7	98256620	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	10343082	98256620	60882043	268	39158											
TRRAP	8295	broad.mit.edu	37	chr7	98545957	98545957	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaacggagcgggcgatgctGatcgaggtaagggccatact	12	6	15	8	4	0	1	0	1	0	0	1	4	0	2	1	4	4	2	1	4	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:98545957G>C	uc003upp.2	+	33	4850	c.4641G>C	c.(4639-4641)CTG>CTC	p.L1547L	TRRAP_uc011kis.1_Silent_p.L1529L|TRRAP_uc003upr.2_Silent_p.L1246L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1547					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GGGCGATGCTGATCGAGGTAA	0.512													13	50					0	0	0	0	C	98545957	C	C	98545957	2	2	214	1	0	0	0	0	0	0	0	1	16668	1277	45	2		2	TRRAP	7	98545957	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	289337	98545957	60592706	269	39159											
MCM7	4176	broad.mit.edu	37	chr7	99696309	99696309	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactcctggcttgggcacatGatcagaggcatgaaagtggg	10	8	14	9	0	1	3	1	2	0	1	2	3	2	3	1	4	0	3	1	4	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:99696309G>A	uc003usw.1	-	6	1122	c.612C>T	c.(610-612)ATC>ATT	p.I204I	MCM7_uc003usv.1_Silent_p.I28I|MCM7_uc003usx.1_Silent_p.I28I|AP4M1_uc011kjg.1_5'Flank|AP4M1_uc010lgl.1_5'Flank|AP4M1_uc003utb.3_5'Flank|AP4M1_uc003utc.3_5'Flank|AP4M1_uc010lgm.2_5'Flank|AP4M1_uc003utd.2_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	204					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	TTGGGCACATGATCAGAGGCA	0.517													25	88					0	0	0	0	A	99696309	A	A	99696309	2	1	214	1	0	0	0	0	0	0	0	1	9445	1280	45	2		2	MCM7	7	99696309	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1150352	99696309	59442354	270	39160											
TAF6	6878	broad.mit.edu	37	chr7	99710524	99710524	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttctgtggcttcagccttCtgttgctctttgggagctgg	2	16	14	9	0	4	0	1	0	3	0	4	1	4	1	1	4	3	5	1	4	0	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:99710524C>T	uc003uti.2	-	6	552	c.471G>A	c.(469-471)CAG>CAA	p.Q157Q	TAF6_uc003utg.2_Silent_p.Q79Q|TAF6_uc003uth.2_Silent_p.Q214Q|TAF6_uc003utk.2_Silent_p.Q157Q|TAF6_uc011kji.1_Silent_p.Q194Q|TAF6_uc003utj.2_Silent_p.Q147Q|TAF6_uc003utl.2_Silent_p.Q157Q|TAF6_uc003utm.2_Silent_p.Q157Q|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	157					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTTCAGCCTTCTGTTGCTCTT	0.532													77	187					0	0	0	0	T	99710524	T	T	99710524	2	4	214	1	0	0	0	0	0	0	0	1	15596	912	32	2		2	TAF6	7	99710524	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	14215	99710524	59428139	271	39161											
FBXL13	222235	broad.mit.edu	37	chr7	102553560	102553560	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagccagagaggtccagataGatgagcttgtggcatccatt	11	9	12	9	0	0	4	0	1	0	3	2	5	2	4	3	2	2	2	3	2	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:102553560G>C	uc003vaq.2	-	11	1408	c.981C>G	c.(979-981)ATC>ATG	p.I327M	FBXL13_uc010liq.1_Missense_Mutation_p.I142M|FBXL13_uc010lir.1_Missense_Mutation_p.I327M|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.I327M|LRRC17_uc003vat.2_5'UTR|LRRC17_uc003vau.2_5'UTR	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	327	LRR 4.										0						GGTCCAGATAGATGAGCTTGT	0.488													5	22					0	0	0	0	C	102553560	C	C	102553560	3	2	214	1	0	0	0	0	1	0	0	0	5741	932	33	2	1266	2	FBXL13	7	102553560	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2843036	102553560	56585103	272	39162											
FSCN3	29999	broad.mit.edu	37	chr7	127236417	127236417	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcttctgagcgcttaaacCgaatgtccttgttccagttt	7	15	8	11	2	1	1	0	1	1	0	3	2	3	1	3	0	3	4	3	0	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:127236417C>T	uc003vmd.1	+	3	1096	c.877C>T	c.(877-879)CGA>TGA	p.R293*	FSCN3_uc011koh.1_Nonsense_Mutation_p.R159*|FSCN3_uc010llc.1_Nonsense_Mutation_p.R293*	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	293						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						GCGCTTAAACCGAATGTCCTT	0.537													44	86					0	0	0	0	T	127236417	T	T	127236417	4	4	214	1	0	0	0	0	0	1	0	0	6103	644	23	1	887	1	FSCN3	7	127236417	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	24682857	127236417	31902246	273	39163											
TMEM140	55281	broad.mit.edu	37	chr7	134849728	134849728	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctgagggctgagagggctGagagcaagcttgagagctgc	9	7	17	8	0	1	4	0	4	1	3	1	7	1	4	0	2	4	5	0	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:134849728G>C	uc003vsi.2	+	2	816	c.535G>C	c.(535-537)GAG>CAG	p.E179Q	C7orf49_uc003vsh.2_Intron	NM_018295	NP_060765	Q9NV12	TM140_HUMAN	transmembrane protein 140	179	Cytoplasmic (Potential).					integral to membrane				large_intestine(1)	1						TGAGAGGGCTGAGAGCAAGCT	0.557													14	30					0	0	0	0	C	134849728	C	C	134849728	3	2	214	1	0	0	0	0	1	0	0	0	16121	1291	45	2	537	2	TMEM140	7	134849728	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	7613311	134849728	24288935	274	39164											
KIAA1549	57670	broad.mit.edu	37	chr7	138603406	138603406	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacacagtggtcacatcagtGtatctgtctgcacttgtggc	9	12	10	10	0	4	0	2	0	2	0	4	0	4	0	0	2	2	2	0	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr7:138603406G>A	uc011kql.1	-	2	1015	c.966C>T	c.(964-966)TAC>TAT	p.Y322Y	KIAA1549_uc003vuk.3_Silent_p.Y272Y|KIAA1549_uc011kqj.1_Silent_p.Y322Y	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	322						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TCACATCAGTGTATCTGTCTG	0.542			O	BRAF	pilocytic astrocytoma								36	48					0	0	0	0	A	138603406	A	A	138603406	2	1	214	1	0	0	0	0	0	0	0	1	8283	1372	48	4		4	KIAA1549	7	138603406	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3753678	138603406	20535257	275	39165											
PDGFRL	5157	broad.mit.edu	37	chr8	17486079	17486079	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacaggctgtggttccttgtCgggtgaccgtgctgtcggcc	3	11	16	11	3	0	1	0	1	0	0	3	2	1	1	3	4	1	3	3	4	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:17486079C>T	uc003wxr.2	+	4	650	c.589C>T	c.(589-591)CGG>TGG	p.R197W		NM_006207	NP_006198	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	197						extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity				0				Colorectal(111;0.0752)		GGTTCCTTGTCGGGTGACCGT	0.532													34	89					0	0	0	0	T	17486079	T	T	17486079	3	4	214	1	0	0	0	0	1	0	0	0	11717	875	31	1	603	1	PDGFRL	8	17486079	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08		17486079	128877943	276	39166											
PIWIL2	55124	broad.mit.edu	37	chr8	22210625	22210625	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatggtggtgtttgtagttCagaagaaaatcagtactaat	14	13	11	3	0	2	3	2	0	0	3	2	3	2	3	0	2	1	4	0	2	6	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:22210625C>T	uc003xbn.2	+	21	2705	c.2557C>T	c.(2557-2559)CAG>TAG	p.Q853*	PIWIL2_uc011kzf.1_Nonsense_Mutation_p.Q853*|PIWIL2_uc010ltv.2_Nonsense_Mutation_p.Q853*|PIWIL2_uc003xbo.2_Nonsense_Mutation_p.Q7*	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	853	Piwi.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		GTTTGTAGTTCAGAAGAAAAT	0.413													33	68					0	0	0	0	T	22210625	T	T	22210625	4	4	214	1	0	0	0	0	0	1	0	0	12013	827	29	2	2635	2	PIWIL2	8	22210625	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4724546	22210625	124153397	277	39167											
BIN3	55909	broad.mit.edu	37	chr8	22494439	22494439	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggggttgacactcactgctGaagttttccatactcccttt	7	15	8	11	0	1	2	1	2	0	0	3	2	3	2	2	2	2	3	2	2	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:22494439G>A	uc003xcl.2	-	3	191	c.94C>T	c.(94-96)CAG>TAG	p.Q32*	BIN3_uc003xck.2_Silent_p.F4F|BIN3_uc010ltw.2_Intron	NM_018688	NP_061158	Q9NQY0	BIN3_HUMAN	bridging integrator 3	32	BAR.|Potential.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity				0		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		ACTCACTGCTGAAGTTTTCCA	0.547													10	44					0	0	0	0	A	22494439	A	A	22494439	4	1	214	1	0	0	0	0	0	1	0	0	1437	1299	45	2	695	2	BIN3	8	22494439	Nonsense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	283814	22494439	123869583	278	39168											
TNFRSF10B	8795	broad.mit.edu	37	chr8	22886091	22886091	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccagggtgtacaatcaccGaccttgaccatccctctggg	8	9	9	15	1	2	1	1	1	1	0	4	2	4	1	5	2	1	1	5	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:22886091G>T	uc003xcu.2	-	5	794	c.501C>A	c.(499-501)GTC>GTA	p.V167V	TNFRSF10B_uc003xcs.1_5'Flank|TNFRSF10B_uc003xct.2_Silent_p.V167V|TNFRSF10B_uc011kzq.1_Silent_p.V16V|TNFRSF10B_uc003xcv.2_Silent_p.V65V	NM_003842	NP_003833	O14763	TR10B_HUMAN	tumor necrosis factor receptor superfamily,	167	Extracellular (Potential).|TNFR-Cys 3.				activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cell surface receptor linked signaling pathway|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|positive regulation of I-kappaB kinase/NF-kappaB cascade	plasma membrane	caspase activator activity|receptor activity|TRAIL binding				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0179)|COAD - Colon adenocarcinoma(73;0.0703)		TACAATCACCGACCTTGACCA	0.562													32	96					9.78485e-24	1.0849e-23	1	0	T	22886091	T	T	22886091	2	4	214	1	0	0	0	0	0	0	0	1	16347	1045	37	3		3	TNFRSF10B	8	22886091	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	391652	22886091	123477931	279	39169											
UNC5D	137970	broad.mit.edu	37	chr8	35616848	35616848	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcctataggaagtggtttCagatgaaaggcatcaaggtg	12	11	12	6	0	3	2	2	1	1	1	4	3	3	3	1	4	0	2	1	4	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:35616848C>G	uc003xjr.1	+	14	2502	c.2174C>G	c.(2173-2175)TCA>TGA	p.S725*	UNC5D_uc003xjs.1_Nonsense_Mutation_p.S720*|UNC5D_uc003xju.1_Nonsense_Mutation_p.S301*	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	725	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GAAGTGGTTTCAGATGAAAGG	0.378													22	68					0	0	0	0	G	35616848	G	G	35616848	4	3	214	1	0	0	0	0	0	1	0	0	17063	838	29	2	2228	2	UNC5D	8	35616848	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	12730757	35616848	110747174	280	39170											
WHSC1L1	54904	broad.mit.edu	37	chr8	38162181	38162181	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggaatgattactacagatGagaatgtaggaggatactaa	16	11	11	3	0	0	3	0	2	0	2	0	7	0	6	0	3	3	1	0	3	7	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:38162181G>A	uc003xli.2	-	14	3053	c.2535C>T	c.(2533-2535)CTC>CTT	p.L845L	WHSC1L1_uc011lbm.1_Silent_p.L845L|WHSC1L1_uc010lwe.2_Silent_p.L845L	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	845					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TACTACAGATGAGAATGTAGG	0.438			T	NUP98	AML								17	94					0	0	0	0	A	38162181	A	A	38162181	2	1	214	1	0	0	0	0	0	0	0	1	17431	1277	45	2		2	WHSC1L1	8	38162181	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2545333	38162181	108201841	281	39171											
THAP1	55145	broad.mit.edu	37	chr8	42693174	42693174	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taacctctttctgatacgtcGtctttctctttctggaagtg	6	18	7	10	2	5	1	0	1	5	0	7	2	5	2	1	1	2	0	1	1	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:42693174G>A	uc003xpk.2	-	3	810	c.573C>T	c.(571-573)GAC>GAT	p.D191D	THAP1_uc003xpl.2_3'UTR	NM_018105	NP_060575	Q9NVV9	THAP1_HUMAN	THAP domain containing, apoptosis associated	191					cell cycle|endothelial cell proliferation|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	sequence-specific DNA binding|zinc ion binding				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Acute lymphoblastic leukemia(644;0.000299)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0377)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CTGATACGTCGTCTTTCTCTT	0.388													24	87					0	0	0	0	A	42693174	A	A	42693174	2	1	214	1	0	0	0	0	0	0	0	1	15907	1136	40	1		1	THAP1	8	42693174	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4530993	42693174	103670848	282	39172											
HGSNAT	138050	broad.mit.edu	37	chr8	43048965	43048965	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaccatcaactccatcgtGatggcctttttaggagttca	9	12	9	11	1	2	1	2	1	0	0	4	2	3	2	3	3	1	2	3	3	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:43048965G>A	uc003xpx.3	+	14	1491	c.1443G>A	c.(1441-1443)GTG>GTA	p.V481V		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	509	Helical; (Potential).		V -> L (does not have any clinical significance; no loss of enzymatic activity).		lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			ACTCCATCGTGATGGCCTTTT	0.403													24	62					0	0	0	0	A	43048965	A	A	43048965	2	1	214	1	0	0	0	0	0	0	0	1	7127	1277	45	2		2	HGSNAT	8	43048965	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	355791	43048965	103315057	283	39173											
KIAA1429	25962	broad.mit.edu	37	chr8	95508622	95508622	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctttgctttgtagaagctgTtttaactctgcagcattaat	9	18	7	7	0	2	1	0	0	2	1	2	1	2	1	0	0	5	6	0	0	4	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:95508622T>C	uc003ygo.1	-	18	4330	c.4317A>G	c.(4315-4317)AAA>AAG	p.K1439K	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1439					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GTAGAAGCTGTTTTAACTCTG	0.393													17	35					0	0	0	0	C	95508622	C	C	95508622	2	2	214	1	0	0	0	0	0	0	0	1	8270	1722	60	5		5	KIAA1429	8	95508622	Silent	SNP	T	TCGA-CV-6961-01A-21D-1912-08	52459657	95508622	50855400	284	39174											
TP53INP1	94241	broad.mit.edu	37	chr8	95942725	95942725	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattagtaattgtactgacgCgggcagggctgatgaacaac	12	10	12	7	2	0	3	0	3	0	0	0	3	0	3	0	2	3	4	0	2	6	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:95942725C>T	uc003yhg.2	-	4	1089	c.705G>A	c.(703-705)CCG>CCA	p.P235P	C8orf38_uc003yhe.1_Intron|C8orf38_uc003yhf.2_Intron|TP53INP1_uc003yhh.2_3'UTR	NM_033285	NP_150601	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	235					apoptosis	PML body					0	Breast(36;8.75e-07)					TGTACTGACGCGGGCAGGGCT	0.438													53	115					0	0	0	0	T	95942725	T	T	95942725	2	4	214	1	0	0	0	0	0	0	0	1	16455	755	27	1		1	TP53INP1	8	95942725	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	434103	95942725	50421297	285	39175											
TSPYL5	85453	broad.mit.edu	37	chr8	98289207	98289207	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttgattttgtagcccaatCtggcaaggccgagctcttcc	8	12	9	12	1	2	1	0	1	2	0	3	2	3	1	3	2	2	3	3	2	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:98289207C>G	uc003yhy.2	-	1	970	c.866G>C	c.(865-867)AGA>ACA	p.R289T		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	289					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					GTAGCCCAATCTGGCAAGGCC	0.473													27	69					0	0	0	0	G	98289207	G	G	98289207	3	3	214	1	0	0	0	0	1	0	0	0	16729	913	32	2	391	2	TSPYL5	8	98289207	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2346482	98289207	48074815	286	39176											
OSR2	116039	broad.mit.edu	37	chr8	99963753	99963753	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcacatctgaacaggaatctCcacacaaatgtcccacatgt	14	9	5	13	0	3	1	1	1	2	0	5	2	4	2	2	1	1	0	2	1	3	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:99963753C>G	uc003yir.2	+	4	1298	c.763C>G	c.(763-765)CCA>GCA	p.P255A	OSR2_uc003yiq.2_Intron|OSR2_uc011lgx.1_Missense_Mutation_p.P376A	NM_001142462	NP_001135934	Q8N2R0	OSR2_HUMAN	odd-skipped related 2 isoform a	255					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			ACAGGAATCTCCACACAAATG	0.428													3	7					0	0	0	0	G	99963753	G	G	99963753	3	3	214	1	0	0	0	0	1	0	0	0	11348	855	30	2	773	2	OSR2	8	99963753	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1674546	99963753	46400269	287	39177											
VPS13B	157680	broad.mit.edu	37	chr8	100866028	100866028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatccaacaaagagttggaaGaatacaaggaaaaatgtttt	19	10	8	4	0	0	2	0	0	0	2	1	4	1	4	1	2	2	2	1	2	9	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:100866028G>A	uc003yiv.2	+	56	10597	c.10486G>A	c.(10486-10488)GAA>AAA	p.E3496K	VPS13B_uc003yiw.2_Missense_Mutation_p.E3471K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3496					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGAGTTGGAAGAATACAAGGA	0.383													23	63					0	0	0	0	A	100866028	A	A	100866028	3	1	214	1	0	0	0	0	1	0	0	0	17258	943	33	2	10898	2	VPS13B	8	100866028	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	902275	100866028	45497994	288	39178											
WDR67	93594	broad.mit.edu	37	chr8	124109599	124109599	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaagctaggcagctctttaGaattatccagatgcccacta	12	10	9	10	0	1	2	0	0	1	2	2	3	2	3	2	2	3	3	2	2	6	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:124109599G>C	uc003ypp.1	+	6	839	c.749G>C	c.(748-750)AGA>ACA	p.R250T	WDR67_uc011lig.1_Missense_Mutation_p.R250T|WDR67_uc011lih.1_Missense_Mutation_p.R140T|WDR67_uc003ypq.1_RNA|WDR67_uc003ypo.1_Missense_Mutation_p.R250T|WDR67_uc003ypr.2_RNA	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	250	WD 4.					centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			CAGCTCTTTAGAATTATCCAG	0.408													13	50					0	0	0	0	C	124109599	C	C	124109599	3	2	214	1	0	0	0	0	1	0	0	0	17386	942	33	2	771	2	WDR67	8	124109599	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	23243571	124109599	22254423	289	39179											
WDR67	93594	broad.mit.edu	37	chr8	124138784	124138784	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttgaaactgtgttctcaGaagtgctgacaagagaggag	12	11	12	6	0	2	4	1	2	2	2	3	6	2	5	0	1	2	2	0	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:124138784G>C	uc003ypp.1	+	13	1831	c.1741G>C	c.(1741-1743)GAA>CAA	p.E581Q	WDR67_uc011lig.1_Missense_Mutation_p.E581Q|WDR67_uc011lih.1_Missense_Mutation_p.E471Q|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Missense_Mutation_p.E294Q|WDR67_uc003ypt.1_Missense_Mutation_p.E38Q|WDR67_uc003ypu.1_Missense_Mutation_p.E38Q	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	581	Rab-GAP TBC.					centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			TGTGTTCTCAGAAGTGCTGAC	0.368													14	28					0	0	0	0	C	124138784	C	C	124138784	3	2	214	1	0	0	0	0	1	0	0	0	17386	943	33	2	1791	2	WDR67	8	124138784	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	29185	124138784	22225238	290	39180											
FAM91A1	157769	broad.mit.edu	37	chr8	124810476	124810476	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcagcagctgcacccctCaggtaaagacctacttggaa	11	8	9	13	0	2	1	2	0	0	1	2	2	2	2	3	2	4	4	3	2	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:124810476C>T	uc003yqv.2	+	16	1619	c.1558C>T	c.(1558-1560)CAG>TAG	p.Q520*	FAM91A1_uc011lik.1_Nonsense_Mutation_p.Q520*|FAM91A1_uc011lil.1_Nonsense_Mutation_p.Q278*	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	520										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			CTGCACCCCTCAGGTAAAGAC	0.453													17	52					0	0	0	0	T	124810476	T	T	124810476	4	4	214	1	0	0	0	0	0	1	0	0	5683	827	29	2	1620	2	FAM91A1	8	124810476	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	671692	124810476	21553546	291	39181											
ZNF572	137209	broad.mit.edu	37	chr8	125989717	125989717	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcccatctcattagacatCagagaacacatacaggagaa	16	7	7	11	0	2	3	2	0	1	3	4	5	3	3	1	1	2	1	1	1	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:125989717C>T	uc003yrr.2	+	3	1362	c.1207C>T	c.(1207-1209)CAG>TAG	p.Q403*		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	403	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CATTAGACATCAGAGAACACA	0.423										HNSCC(60;0.17)			10	56					0	0	0	0	T	125989717	T	T	125989717	4	4	214	1	0	0	0	0	0	1	0	0	18071	827	29	2	1213	2	ZNF572	8	125989717	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1179241	125989717	20374305	292	39182											
FAM135B	51059	broad.mit.edu	37	chr8	139164359	139164359	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccatcttgctgcttggtgtCcgcatcttcagcagcctcct	4	14	8	15	1	3	0	1	0	2	0	6	0	6	0	4	1	4	4	4	1	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:139164359C>T	uc003yuy.2	-	13	2530	c.2359G>A	c.(2359-2361)GAC>AAC	p.D787N	FAM135B_uc003yux.2_Missense_Mutation_p.D688N|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.D349N|FAM135B_uc003yvb.2_Missense_Mutation_p.D349N	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	787										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGCTTGGTGTCCGCATCTTCA	0.522										HNSCC(54;0.14)			8	55					0	0	0	0	T	139164359	T	T	139164359	3	4	214	1	0	0	0	0	1	0	0	0	5477	855	30	2	1893	2	FAM135B	8	139164359	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	13174642	139164359	7199663	293	39183											
FAM135B	51059	broad.mit.edu	37	chr8	139164976	139164976	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaatccatacttatctctaGagctcctactctcatgctga	10	14	4	13	0	2	2	1	1	2	1	6	2	4	2	2	0	4	2	2	0	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:139164976G>C	uc003yuy.2	-	13	1913	c.1742C>G	c.(1741-1743)TCT>TGT	p.S581C	FAM135B_uc003yux.2_Missense_Mutation_p.S482C|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.S143C|FAM135B_uc003yvb.2_Missense_Mutation_p.S143C	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	581										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTTATCTCTAGAGCTCCTACT	0.478										HNSCC(54;0.14)			34	95					0	0	0	0	C	139164976	C	C	139164976	3	2	214	1	0	0	0	0	1	0	0	0	5477	942	33	2	2510	2	FAM135B	8	139164976	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	617	139164976	7199046	294	39184											
CYP11B1	1584	broad.mit.edu	37	chr8	143961152	143961152	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctggggacccgggcggctctCgtgcccagtgcctgtgccct	2	8	15	16	3	1	0	0	0	1	0	2	1	1	1	4	4	3	1	4	4	0	0	rs147788769		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:143961152C>G	uc003yxi.2	-	1	85	c.78G>C	c.(76-78)ACG>ACC	p.T26T	CYP11B1_uc003yxj.2_Silent_p.T26T|CYP11B1_uc010mey.2_Silent_p.T26T	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	26					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GGGCGGCTCTCGTGCCCAGTG	0.652									Familial_Hyperaldosteronism_type_I				20	77					0	0	0	0	G	143961152	G	G	143961152	2	3	214	1	0	0	0	0	0	0	0	1	4162	871	31	3		3	CYP11B1	8	143961152	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4796176	143961152	2402870	295	39185											
EPPK1	83481	broad.mit.edu	37	chr8	144943311	144943311	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcctggggcaggtgcacccCgtggacagggtccaccacac	7	4	14	16	2	0	0	0	0	0	0	1	1	1	1	5	5	1	2	5	5	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:144943311C>T	uc003zaa.1	-	1	4124	c.4111G>A	c.(4111-4113)GGG>AGG	p.G1371R		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1371	Plectin 24.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGGTGCACCCCGTGGACAGGG	0.637													8	31					0	0	0	0	T	144943311	T	T	144943311	3	4	214	1	0	0	0	0	1	0	0	0	5214	652	23	1	3155	1	EPPK1	8	144943311	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	982159	144943311	1420711	296	39186											
PLEC	5339	broad.mit.edu	37	chr8	144991749	144991749	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtcgtccgaggggtcggtCaggatctcgttcatctcctc	4	12	13	12	4	4	0	2	0	2	0	10	2	5	1	2	4	0	1	2	4	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:144991749C>T	uc003zaf.1	-	32	12821	c.12651G>A	c.(12649-12651)CTG>CTA	p.L4217L	PLEC_uc003zab.1_Silent_p.L4080L|PLEC_uc003zac.1_Silent_p.L4084L|PLEC_uc003zad.2_Silent_p.L4080L|PLEC_uc003zae.1_Silent_p.L4048L|PLEC_uc003zag.1_Silent_p.L4058L|PLEC_uc003zah.2_Silent_p.L4066L|PLEC_uc003zaj.2_Silent_p.L4107L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4217	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGGGGTCGGTCAGGATCTCGT	0.617													12	45					0	0	0	0	T	144991749	T	T	144991749	2	4	214	1	0	0	0	0	0	0	0	1	12107	813	29	2		2	PLEC	8	144991749	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	48438	144991749	1372273	297	39187											
PLEC	5339	broad.mit.edu	37	chr8	144998102	144998102	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttccgctgccgtgcggcctCctcctcggccgccaggctct	1	9	11	20	5	1	0	0	0	1	0	5	0	4	0	7	3	2	2	7	3	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:144998102C>G	uc003zaf.1	-	31	6576	c.6406G>C	c.(6406-6408)GAG>CAG	p.E2136Q	PLEC_uc003zab.1_Missense_Mutation_p.E1999Q|PLEC_uc003zac.1_Missense_Mutation_p.E2003Q|PLEC_uc003zad.2_Missense_Mutation_p.E1999Q|PLEC_uc003zae.1_Missense_Mutation_p.E1967Q|PLEC_uc003zag.1_Missense_Mutation_p.E1977Q|PLEC_uc003zah.2_Missense_Mutation_p.E1985Q|PLEC_uc003zaj.2_Missense_Mutation_p.E2026Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2136	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGTGCGGCCTCCTCCTCGGCC	0.746													3	21					0	0	0	0	G	144998102	G	G	144998102	3	3	214	1	0	0	0	0	1	0	0	0	12107	864	30	2	7656	2	PLEC	8	144998102	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	6353	144998102	1365920	298	39188											
PLEC	5339	broad.mit.edu	37	chr8	145007122	145007122	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacccaggccagcaggtcctGcaggtagcgcagagtggagt	9	5	15	12	1	0	1	0	0	0	1	1	2	1	2	3	4	3	4	3	4	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:145007122G>A	uc003zaf.1	-	14	2157	c.1987C>T	c.(1987-1989)CAG>TAG	p.Q663*	PLEC_uc003zab.1_Nonsense_Mutation_p.Q526*|PLEC_uc003zac.1_Nonsense_Mutation_p.Q530*|PLEC_uc003zad.2_Nonsense_Mutation_p.Q526*|PLEC_uc003zae.1_Nonsense_Mutation_p.Q494*|PLEC_uc003zag.1_Nonsense_Mutation_p.Q504*|PLEC_uc003zah.2_Nonsense_Mutation_p.Q512*|PLEC_uc003zaj.2_Nonsense_Mutation_p.Q553*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	663	Spectrin 1.|Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGCAGGTCCTGCAGGTAGCGC	0.697													6	29					0	0	0	0	A	145007122	A	A	145007122	4	1	214	1	0	0	0	0	0	1	0	0	12107	1328	46	4	12143	4	PLEC	8	145007122	Nonsense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9020	145007122	1356900	299	39189											
ARHGAP39	80728	broad.mit.edu	37	chr8	145771162	145771162	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcggctctgccggctgctCtcgaactgggcacaggcagc	5	7	14	15	3	2	0	0	0	2	0	3	1	2	0	1	4	5	5	1	4	1	0	rs149131924		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr8:145771162C>G	uc003zdt.1	-	7	2547	c.1992G>C	c.(1990-1992)GAG>GAC	p.E664D	ARHGAP39_uc011llk.1_Missense_Mutation_p.E664D|ARHGAP39_uc003zds.1_Missense_Mutation_p.E664D	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	664					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						GCCGGCTGCTCTCGAACTGGG	0.677													6	20					0	0	0	0	G	145771162	G	G	145771162	3	3	214	1	0	0	0	0	1	0	0	0	884	912	32	2	1380	2	ARHGAP39	8	145771162	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	764040	145771162	592860	300	39190											
FOXD4	2298	broad.mit.edu	37	chr9	117879	117879	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgaactcggtgccaaactCtgaggggtcgctcgggccgc	6	7	14	14	4	1	2	0	2	1	0	4	2	1	2	3	4	3	1	3	4	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:117879C>G	uc003zfz.2	-	1	539	c.241G>C	c.(241-243)GAG>CAG	p.E81Q		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	81					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GTGCCAAACTCTGAGGGGTCG	0.711													14	246					0	0	0	0	G	117879	G	G	117879	3	3	214	1	0	0	0	0	1	0	0	0	6031	922	32	2	1082	2	FOXD4	9	117879	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08		117879	141095552	301	39191											
PTPRD	5789	broad.mit.edu	37	chr9	8524994	8524994	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtggcaacacactcatattTtccttggtcagactcttcac	9	13	7	12	0	4	1	3	0	1	1	5	1	5	1	1	3	1	1	1	3	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:8524994T>C	uc003zkk.2	-	17	1321	c.610A>G	c.(610-612)AAA>GAA	p.K204E	PTPRD_uc003zkp.2_Missense_Mutation_p.K204E|PTPRD_uc003zkq.2_Missense_Mutation_p.K204E|PTPRD_uc003zkr.2_Missense_Mutation_p.K198E|PTPRD_uc003zks.2_Missense_Mutation_p.K198E|PTPRD_uc003zkl.2_Missense_Mutation_p.K204E|PTPRD_uc003zkm.2_Missense_Mutation_p.K195E|PTPRD_uc003zkn.2_Missense_Mutation_p.K204E|PTPRD_uc003zko.2_Missense_Mutation_p.K201E	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	204	Extracellular (Potential).|Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CACTCATATTTTCCTTGGTCA	0.348										TSP Lung(15;0.13)			49	135					0	0	0	0	C	8524994	C	C	8524994	3	2	214	1	0	0	0	0	1	0	0	0	12864	1850	64	5	5312	5	PTPRD	9	8524994	Missense_Mutation	SNP	T	TCGA-CV-6961-01A-21D-1912-08	8407115	8524994	132688437	302	39192											
TOPORS	10210	broad.mit.edu	37	chr9	32542604	32542604	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgatctctttttgtctcttCtccctctaggtctgctactt	3	21	5	12	0	5	1	0	1	5	0	8	1	5	1	1	1	2	1	1	1	2	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:32542604C>T	uc003zrb.2	-	3	2086	c.1919G>A	c.(1918-1920)AGA>AAA	p.R640K	TOPORS_uc003zrc.2_Missense_Mutation_p.R573K	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	640	Arg-rich.|Interaction with TOP1.|Interaction with SUMO1.|Interaction with p53/TP53.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TTTGTCTCTTCTCCCTCTAGG	0.423													80	236					0	0	0	0	T	32542604	T	T	32542604	3	4	214	1	0	0	0	0	1	0	0	0	16437	913	32	2	1222	2	TOPORS	9	32542604	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	24017610	32542604	108670827	303	39193											
PRSS3	5646	broad.mit.edu	37	chr9	33796723	33796723	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcccctaccaggtgtccctGaattctggctcccacttctg	5	12	7	17	0	2	1	0	1	2	0	5	1	5	1	5	2	1	1	5	2	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:33796723G>A	uc003ztj.3	+	2	294	c.294G>A	c.(292-294)CTG>CTA	p.L98L	uc003ztk.1_Intron|PRSS3_uc003zti.3_Silent_p.L55L|PRSS3_uc003ztl.3_Silent_p.L41L	NM_007343	NP_031369	P35030	TRY3_HUMAN	mesotrypsin isoform 1 preproprotein	98	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity				0			LUSC - Lung squamous cell carcinoma(29;0.0176)			AGGTGTCCCTGAATTCTGGCT	0.547													7	178					0	0	0	0	A	33796723	A	A	33796723	2	1	214	1	0	0	0	0	0	0	0	1	12684	1277	45	2		2	PRSS3	9	33796723	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1254119	33796723	107416708	304	39194											
FAM75A6	389730	broad.mit.edu	37	chr9	43627818	43627818	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgatgagttaaaggcgcacGaggttctggcagtctcctgc	8	10	13	10	2	2	2	0	2	2	0	3	3	2	2	1	3	1	4	1	3	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:43627818G>A	uc011lrb.1	-	4	898	c.869C>T	c.(868-870)TCG>TTG	p.S290L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	290						integral to membrane					0						AAAGGCGCACGAGGTTCTGGC	0.552													83	82					0	0	0	0	A	43627818	A	A	43627818	3	1	214	1	0	0	0	0	1	0	0	0	5654	1059	37	1	3166	1	FAM75A6	9	43627818	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9831095	43627818	97585613	305	39195											
PRUNE2	158471	broad.mit.edu	37	chr9	79244121	79244121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttacttgatgatgctctCtggaatgtggatgcaatcca	10	13	10	8	0	1	2	0	2	1	0	3	5	2	4	1	2	3	2	1	2	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:79244121C>T	uc010mpk.2	-	16	9260	c.9136G>A	c.(9136-9138)GAG>AAG	p.E3046K	PRUNE2_uc011lsk.1_Missense_Mutation_p.E295K|PRUNE2_uc011lsl.1_Missense_Mutation_p.E310K|PRUNE2_uc011lsm.1_Missense_Mutation_p.E311K|PRUNE2_uc004akj.3_Missense_Mutation_p.E500K	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	3046	CRAL-TRIO.				apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ATGATGCTCTCTGGAATGTGG	0.274													4	14					0	0	0	0	T	79244121	T	T	79244121	3	4	214	1	0	0	0	0	1	0	0	0	12703	922	32	2	146	2	PRUNE2	9	79244121	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	35616303	79244121	61969310	306	39196											
UBQLN1	29979	broad.mit.edu	37	chr9	86276731	86276731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggagcccagtaacctttCaatagctgcattgatatcac	11	11	8	11	0	2	1	2	1	0	0	2	2	2	2	2	1	4	3	2	1	4	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:86276731C>T	uc004amv.2	-	11	2315	c.1741G>A	c.(1741-1743)GAA>AAA	p.E581K	UBQLN1_uc004amw.2_Missense_Mutation_p.E553K	NM_013438	NP_038466	Q9UMX0	UBQL1_HUMAN	ubiquilin 1 isoform 1	581	UBA.				apoptosis|regulation of protein ubiquitination|response to hypoxia	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm|proteasome complex	kinase binding				0						AGTAACCTTTCAATAGCTGCA	0.383													24	69					0	0	0	0	T	86276731	T	T	86276731	3	4	214	1	0	0	0	0	1	0	0	0	16964	835	29	2	32	2	UBQLN1	9	86276731	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	7032610	86276731	54936700	307	39197											
KIF27	55582	broad.mit.edu	37	chr9	86518439	86518439	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctctgttggcatatttgaGagaatttaaggactcatcaa	12	14	9	6	0	3	2	2	1	1	1	3	4	3	3	0	2	1	3	0	2	4	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:86518439G>C	uc004ana.2	-	4	1138	c.994C>G	c.(994-996)CTC>GTC	p.L332V	KIF27_uc010mpw.2_Missense_Mutation_p.L332V|KIF27_uc010mpx.2_Missense_Mutation_p.L332V	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	332					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						GCATATTTGAGAGAATTTAAG	0.433													22	80					0	0	0	0	C	86518439	C	C	86518439	3	2	214	1	0	0	0	0	1	0	0	0	8335	942	33	2	3271	2	KIF27	9	86518439	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	241708	86518439	54694992	308	39198											
BICD2	23299	broad.mit.edu	37	chr9	95481630	95481630	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtacttgcaggccaagatctCaggcccgttgatgtccacct	8	10	10	13	1	1	2	1	1	1	1	3	2	2	2	4	2	2	3	4	2	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:95481630C>G	uc004aso.1	-	5	1354	c.1297G>C	c.(1297-1299)GAG>CAG	p.E433Q	BICD2_uc004asp.1_Missense_Mutation_p.E433Q	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	433	Potential.				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						GCCAAGATCTCAGGCCCGTTG	0.637													6	56					0	0	0	0	G	95481630	G	G	95481630	3	3	214	1	0	0	0	0	1	0	0	0	1432	835	29	2	1292	2	BICD2	9	95481630	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	8963191	95481630	45731801	309	39199											
KIAA1529	57653	broad.mit.edu	37	chr9	100056386	100056386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagtggctatgagggagcaGacatgggtaagtgaccagca	13	6	16	6	0	0	4	0	2	0	2	0	5	0	5	1	3	2	4	1	3	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:100056386G>A	uc011lut.1	+	11	1017	c.244G>A	c.(244-246)GAC>AAC	p.D82N	KIAA1529_uc011lur.1_RNA|KIAA1529_uc004axe.1_Missense_Mutation_p.D82N|KIAA1529_uc011lus.1_Intron|KIAA1529_uc010msm.1_RNA	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TGAGGGAGCAGACATGGGTAA	0.607													21	50					0	0	0	0	A	100056386	A	A	100056386	3	1	214	1	0	0	0	0	1	0	0	0	8279	942	33	2	250	2	KIAA1529	9	100056386	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4574756	100056386	41157045	310	39200											
SVEP1	79987	broad.mit.edu	37	chr9	113169862	113169862	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtaccatacagaaagtttGatgaatgtgtagcaggagac	14	10	12	5	0	0	4	0	2	0	2	0	5	0	4	1	2	3	4	1	2	5	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:113169862G>A	uc010mtz.2	-	38	8355	c.8018C>T	c.(8017-8019)TCA>TTA	p.S2673L	SVEP1_uc010mty.2_Missense_Mutation_p.S599L	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2673	Sushi 21.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CAGAAAGTTTGATGAATGTGT	0.443													55	167					0	0	0	0	A	113169862	A	A	113169862	3	1	214	1	0	0	0	0	1	0	0	0	15486	1294	45	2	2741	2	SVEP1	9	113169862	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	13113476	113169862	28043569	311	39201											
WDR31	114987	broad.mit.edu	37	chr9	116083793	116083793	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgctcagtaagcccacctGagggttttatcttcagaggt	8	12	11	10	0	3	2	2	1	1	1	3	2	3	2	2	2	2	4	2	2	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:116083793G>A	uc004bhe.2	-	8	888	c.636C>T	c.(634-636)CTC>CTT	p.L212L	WDR31_uc004bhc.2_Silent_p.L211L|WDR31_uc004bhd.2_Silent_p.L87L|WDR31_uc004bhf.2_RNA	NM_001012361	NP_001012361	Q8NA23	WDR31_HUMAN	WD repeat domain 31 isoform 1	212	WD 4.										0						AAGCCCACCTGAGGGTTTTAT	0.478													13	26					0	0	0	0	A	116083793	A	A	116083793	2	1	214	1	0	0	0	0	0	0	0	1	17354	1277	45	2		2	WDR31	9	116083793	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2913931	116083793	25129638	312	39202											
HDHD3	81932	broad.mit.edu	37	chr9	116136231	116136231	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctagccgtcggtcaaagttgGagatcactgccagtctcaga	10	9	11	11	2	3	2	3	0	1	2	5	3	3	2	2	2	2	1	2	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:116136231G>C	uc004bhi.1	-	2	1188	c.404C>G	c.(403-405)TCC>TGC	p.S135C	HDHD3_uc004bhj.2_Missense_Mutation_p.S135C|HDHD3_uc004bhk.2_Missense_Mutation_p.S135C	NM_031219	NP_112496	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain	135							phosphoglycolate phosphatase activity|protein binding				0						GTCAAAGTTGGAGATCACTGC	0.622													43	137					0	0	0	0	C	116136231	C	C	116136231	3	2	214	1	0	0	0	0	1	0	0	0	7063	1174	41	2	355	2	HDHD3	9	116136231	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	52438	116136231	25077200	313	39203											
OR1L3	26735	broad.mit.edu	37	chr9	125438072	125438072	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatctcttatctaagaattCtcatcgctgttctcaagatt	10	17	4	10	1	5	2	3	0	4	2	9	2	5	2	0	0	0	2	0	0	4	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:125438072C>T	uc011lzb.1	+	1	664	c.664C>T	c.(664-666)CTC>TTC	p.L222F		NM_001005234	NP_001005234	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCTAAGAATTCTCATCGCTGT	0.468													23	72					0	0	0	0	T	125438072	T	T	125438072	3	4	214	1	0	0	0	0	1	0	0	0	11018	913	32	2	666	2	OR1L3	9	125438072	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	9301841	125438072	15775359	314	39204											
GAPVD1	26130	broad.mit.edu	37	chr9	128086134	128086134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctagaaggagagtctgtgtCagaacttggagcaggacctt	11	9	13	8	0	2	3	1	0	1	3	2	6	2	5	2	3	2	1	2	3	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:128086134C>T	uc010mwx.2	+	11	2116	c.1790C>T	c.(1789-1791)TCA>TTA	p.S597L	GAPVD1_uc011lzs.1_Missense_Mutation_p.S597L|GAPVD1_uc004bpp.2_Missense_Mutation_p.S597L|GAPVD1_uc004bpq.2_Missense_Mutation_p.S597L|GAPVD1_uc004bpr.2_Missense_Mutation_p.S576L|GAPVD1_uc004bps.2_Missense_Mutation_p.S597L|GAPVD1_uc010mwy.1_Missense_Mutation_p.S456L	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	597					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GAGTCTGTGTCAGAACTTGGA	0.428													11	53					0	0	0	0	T	128086134	T	T	128086134	3	4	214	1	0	0	0	0	1	0	0	0	6274	838	29	2	1820	2	GAPVD1	9	128086134	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2648062	128086134	13127297	315	39205											
FUBP3	8939	broad.mit.edu	37	chr9	133507625	133507625	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgacccagggctggggcagCacctaccaggcgtggcagca	8	4	15	14	1	0	1	0	1	0	0	0	1	0	1	3	5	3	5	3	5	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:133507625C>A	uc004bzr.1	+	16	1578	c.1470C>A	c.(1468-1470)AGC>AGA	p.S490R	FUBP3_uc004bzs.1_Missense_Mutation_p.S403R	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	490					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		GCTGGGGCAGCACCTACCAGG	0.622													12	32					4.3838e-07	4.61298e-07	1	0	A	133507625	A	A	133507625	3	1	214	1	0	0	0	0	1	0	0	0	6127	709	25	4	1532	4	FUBP3	9	133507625	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5421491	133507625	7705806	316	39206											
RALGDS	5900	broad.mit.edu	37	chr9	135982483	135982483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggcataccctggccacctCgatccagtgctccaccaccc	7	7	7	20	1	0	0	0	0	0	0	3	1	2	0	7	2	2	2	7	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:135982483C>T	uc004cco.2	-	7	1422	c.1402G>A	c.(1402-1404)GAG>AAG	p.E468K	RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Missense_Mutation_p.E456K|RALGDS_uc004ccr.2_Missense_Mutation_p.E467K|RALGDS_uc011mcv.1_Missense_Mutation_p.E439K|RALGDS_uc004ccs.2_Missense_Mutation_p.E413K|RALGDS_uc011mcw.1_Missense_Mutation_p.E539K|RALGDS_uc004ccv.1_Missense_Mutation_p.E237K|RALGDS_uc004ccu.1_Missense_Mutation_p.E237K	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	468	Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CTGGCCACCTCGATCCAGTGC	0.622			T	CIITA	PMBL|Hodgkin Lymphona|								12	57					0	0	0	0	T	135982483	T	T	135982483	3	4	214	1	0	0	0	0	1	0	0	0	13081	893	31	1	1390	1	RALGDS	9	135982483	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2474858	135982483	5230948	317	39207											
RALGDS	5900	broad.mit.edu	37	chr9	135985044	135985044	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcctggggtccaccatcctCgtcggaataggggaggatgc	7	8	15	11	2	0	0	0	0	0	0	5	3	3	3	4	6	1	0	4	6	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:135985044C>T	uc004cco.2	-	4	573	c.553G>A	c.(553-555)GAG>AAG	p.E185K	RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Missense_Mutation_p.E173K|RALGDS_uc004ccr.2_Missense_Mutation_p.E184K|RALGDS_uc011mcv.1_Missense_Mutation_p.E156K|RALGDS_uc004ccs.2_Missense_Mutation_p.E130K|RALGDS_uc011mcw.1_Missense_Mutation_p.E256K|RALGDS_uc004ccv.1_5'Flank|RALGDS_uc004ccu.1_5'Flank	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	185	N-terminal Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CCACCATCCTCGTCGGAATAG	0.418			T	CIITA	PMBL|Hodgkin Lymphona|								18	61					0	0	0	0	T	135985044	T	T	135985044	3	4	214	1	0	0	0	0	1	0	0	0	13081	893	31	1	2251	1	RALGDS	9	135985044	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2561	135985044	5228387	318	39208											
SARDH	1757	broad.mit.edu	37	chr9	136596561	136596561	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgggtacagagtcttggtctCtgccgggctcagcacatggg	6	9	15	11	2	3	1	1	0	2	1	4	1	3	1	1	4	3	3	1	4	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:136596561C>G	uc004cep.3	-	4	690	c.556G>C	c.(556-558)GAG>CAG	p.E186Q	SARDH_uc004ceo.2_Missense_Mutation_p.E186Q|SARDH_uc011mdn.1_Missense_Mutation_p.E186Q|SARDH_uc011mdo.1_Missense_Mutation_p.E18Q	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	186					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GTCTTGGTCTCTGCCGGGCTC	0.627													7	71					0	0	0	0	G	136596561	G	G	136596561	3	3	214	1	0	0	0	0	1	0	0	0	13906	922	32	2	2272	2	SARDH	9	136596561	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	611517	136596561	4616870	319	39209											
PMPCA	23203	broad.mit.edu	37	chr9	139309033	139309033	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatgtatgctgtgtctgctGatagcaaaggcttggacacg	9	11	12	9	1	1	1	0	1	1	0	1	2	1	2	1	2	3	5	1	2	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:139309033G>C	uc004chl.2	+	5	471	c.466G>C	c.(466-468)GAT>CAT	p.D156H	PMPCA_uc011mdy.1_Missense_Mutation_p.D156H|PMPCA_uc010nbk.2_RNA|PMPCA_uc010nbl.2_Missense_Mutation_p.D56H|PMPCA_uc011mdz.1_Intron|PMPCA_uc004chm.1_5'Flank	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	156					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		TGTGTCTGCTGATAGCAAAGG	0.572													6	94					0	0	0	0	C	139309033	C	C	139309033	3	2	214	1	0	0	0	0	1	0	0	0	12195	1290	45	2	484	2	PMPCA	9	139309033	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2712472	139309033	1904398	320	39210											
MAMDC4	158056	broad.mit.edu	37	chr9	139749723	139749723	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagatcctcctggccgggcaGacaggcccggggggcgtcgt	5	5	17	14	4	0	2	0	0	0	2	3	2	2	2	4	6	0	1	4	6	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:139749723G>A	uc004cjs.2	+	11	1265	c.1215G>A	c.(1213-1215)CAG>CAA	p.Q405Q	MAMDC4_uc011mej.1_Intron	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	405	MAM 2.|Extracellular (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		TGGCCGGGCAGACAGGCCCGG	0.672													21	22					0	0	0	0	A	139749723	A	A	139749723	2	1	214	1	0	0	0	0	0	0	0	1	9257	933	33	2		2	MAMDC4	9	139749723	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	440690	139749723	1463708	321	39211											
ABCA2	20	broad.mit.edu	37	chr9	139909920	139909920	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagcgtgaggcggtacccgtCgccataggtgcccttgagga	7	7	15	12	4	0	2	0	2	0	0	1	3	0	3	3	4	3	1	3	4	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:139909920C>T	uc011mem.1	-	23	3788	c.3640G>A	c.(3640-3642)GAC>AAC	p.D1214N	ABCA2_uc011mel.1_Missense_Mutation_p.D1215N|ABCA2_uc004ckl.1_Missense_Mutation_p.D1145N|ABCA2_uc004ckm.1_Missense_Mutation_p.D1245N|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1214	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGGTACCCGTCGCCATAGGTG	0.662													3	10					0	0	0	0	T	139909920	T	T	139909920	3	4	214	1	0	0	0	0	1	0	0	0	32	884	31	1	3771	1	ABCA2	9	139909920	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	160197	139909920	1303511	322	39212			1	57		4	4	3315	C		5.54606e-05
ABCA2	20	broad.mit.edu	37	chr9	139910481	139910481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgagtagaaccagaggtgttCctccaccgtgagccggtcaa	10	8	12	11	2	1	4	1	2	0	2	3	4	3	4	5	2	2	2	5	2	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:139910481C>T	uc011mem.1	-	21	3395	c.3247G>A	c.(3247-3249)GAA>AAA	p.E1083K	ABCA2_uc011mel.1_Missense_Mutation_p.E1084K|ABCA2_uc004ckl.1_Missense_Mutation_p.E1014K|ABCA2_uc004ckm.1_Missense_Mutation_p.E1114K|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1083	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CAGAGGTGTTCCTCCACCGTG	0.622													23	35					0	0	0	0	T	139910481	T	T	139910481	3	4	214	1	0	0	0	0	1	0	0	0	32	864	30	2	4172	2	ABCA2	9	139910481	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	561	139910481	1302950	323	39213			1	57		4	4	3315	C		5.54606e-05
ABCA2	20	broad.mit.edu	37	chr9	139910547	139910547	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccaggttcttgcggatctCatccatctccgtgcggatgt	5	12	11	13	3	3	0	1	0	3	0	6	2	4	2	3	3	2	1	3	3	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:139910547C>T	uc011mem.1	-	21	3329	c.3181G>A	c.(3181-3183)GAG>AAG	p.E1061K	ABCA2_uc011mel.1_Missense_Mutation_p.E1062K|ABCA2_uc004ckl.1_Missense_Mutation_p.E992K|ABCA2_uc004ckm.1_Missense_Mutation_p.E1092K|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1061	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TTGCGGATCTCATCCATCTCC	0.612													31	63					0	0	0	0	T	139910547	T	T	139910547	3	4	214	1	0	0	0	0	1	0	0	0	32	835	29	2	4238	2	ABCA2	9	139910547	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	66	139910547	1302884	324	39214			1	57		4	4	3315	C		5.54606e-05
ABCA2	20	broad.mit.edu	37	chr9	139913234	139913234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtagttgacaatgctctcctCgtcgtggaagcccttgaaga	9	11	11	10	2	1	3	0	2	1	1	4	4	1	4	2	1	2	3	2	1	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr9:139913234C>T	uc011mem.1	-	12	1901	c.1753G>A	c.(1753-1755)GAG>AAG	p.E585K	ABCA2_uc011mel.1_Missense_Mutation_p.E586K|ABCA2_uc004ckl.1_Missense_Mutation_p.E516K|ABCA2_uc004ckm.1_Missense_Mutation_p.E616K|ABCA2_uc004ckn.1_5'Flank|ABCA2_uc004cko.1_Missense_Mutation_p.E362K	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	585					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		ATGCTCTCCTCGTCGTGGAAG	0.527													17	51					0	0	0	0	T	139913234	T	T	139913234	3	4	214	1	0	0	0	0	1	0	0	0	32	893	31	1	5702	1	ABCA2	9	139913234	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2687	139913234	1300197	325	39215			1	57		4	4	3315	C		5.54606e-05
SVIL	6840	broad.mit.edu	37	chr10	29821937	29821937	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaaagccagtagggttttCttgctttgctcgagagcttc	7	14	10	10	1	1	1	0	0	1	1	4	2	2	1	2	1	4	5	2	1	2	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr10:29821937C>A	uc001iut.1	-	8	2112	c.1359G>T	c.(1357-1359)AAG>AAT	p.K453N	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_Missense_Mutation_p.K453N	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	453					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				GTAGGGTTTTCTTGCTTTGCT	0.383													25	38					0.00106085	0.00109287	1	0	A	29821937	A	A	29821937	3	1	214	1	0	0	0	0	1	0	0	0	15487	912	32	2	5409	2	SVIL	10	29821937	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08		29821937	105712810	326	39216											
DNA2	1763	broad.mit.edu	37	chr10	70231756	70231756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacccgcagatgtcccaaatGacctgcgccaggccgcccct	9	5	9	18	3	0	2	0	1	0	1	1	2	1	2	7	1	2	1	7	1	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr10:70231756G>A	uc001jof.2	-	1	124	c.124C>T	c.(124-126)CAT>TAT	p.H42Y	DNA2_uc001jog.1_5'Flank|DNA2_uc001joh.1_Intron	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	Error:Variant_position_missing_in_P51530_after_alignment					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						TGTCCCAAATGACCTGCGCCA	0.657													17	20					0	0	0	0	A	70231756	A	A	70231756	3	1	214	1	0	0	0	0	1	0	0	0	4618	1290	45	2	3400	2	DNA2	10	70231756	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	40409819	70231756	65302991	327	39217											
ADAMTS14	140766	broad.mit.edu	37	chr10	72492036	72492036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacccgtcactggcatgtgtCaccccctgaggagctgtgcc	6	8	11	16	1	2	1	2	1	0	0	2	2	2	2	4	2	2	2	4	2	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr10:72492036C>T	uc001jrh.2	+	7	1129	c.1129C>T	c.(1129-1131)CAC>TAC	p.H377Y	ADAMTS14_uc001jrg.2_Missense_Mutation_p.H380Y|ADAMTS14_uc001jri.1_5'Flank	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	377	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G377D(1)		ovary(5)|upper_aerodigestive_tract(1)	6						TGGCATGTGTCACCCCCTGAG	0.597													3	23					0	0	0	0	T	72492036	T	T	72492036	3	4	214	1	0	0	0	0	1	0	0	0	259	826	29	2	1164	2	ADAMTS14	10	72492036	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2260280	72492036	63042711	328	39218											
NRAP	4892	broad.mit.edu	37	chr10	115368262	115368262	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaatgagtggggatgctgccGatatttactctgaattcaca	11	12	11	7	1	2	2	1	2	1	0	2	5	2	3	1	2	3	1	1	2	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr10:115368262G>A	uc001laj.2	-	32	3777	c.3613C>T	c.(3613-3615)CGG>TGG	p.R1205W	NRAP_uc009xyb.2_Intron|NRAP_uc001lak.2_Missense_Mutation_p.R1170W|NRAP_uc001lal.3_Missense_Mutation_p.R1205W	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1205	Nebulin 31.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GGATGCTGCCGATATTTACTC	0.438													60	116					0	0	0	0	A	115368262	A	A	115368262	3	1	214	1	0	0	0	0	1	0	0	0	10692	1057	37	1	1623	1	NRAP	10	115368262	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	42876226	115368262	20166485	329	39219											
DPYSL4	10570	broad.mit.edu	37	chr10	134012379	134012379	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggctgaggcggtgtaccgaGctgtcaccatcgccaagcag	9	6	14	12	3	1	1	1	1	0	0	2	2	1	1	3	3	3	4	3	3	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr10:134012379G>A	uc009ybb.2	+	8	869	c.715G>A	c.(715-717)GCT>ACT	p.A239T		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	239					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GGTGTACCGAGCTGTCACCAT	0.657													4	41					0	0	0	0	A	134012379	A	A	134012379	3	1	214	1	0	0	0	0	1	0	0	0	4771	971	34	4	745	4	DPYSL4	10	134012379	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	18644117	134012379	1522368	330	39220											
EIF3F	8665	broad.mit.edu	37	chr11	8008839	8008839	+	5'Flank	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggtgtatattcagcctatCaagctcctgatattcatgaa	11	14	8	8	0	3	2	3	2	0	0	4	2	4	2	2	1	2	2	2	1	6	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:8008839C>G	uc001mfw.2	+						EIF3F_uc010rbj.1_Translation_Start_Site	NM_003754	NP_003745	O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3,							cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(1)	1				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTCAGCCTATCAAGCTCCTGA	0.493											OREG0020726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	215					0	0	0	0	G	8008839	G	G	8008839	1	3	214	0	1	0	0	0	0	0	0	0	5040	841	29	2		2	EIF3F	11	8008839	5'Flank	SNP	C	TCGA-CV-6961-01A-21D-1912-08		8008839	126997677	331	39221											
SCUBE2	57758	broad.mit.edu	37	chr11	9087482	9087482	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttatccccatccaccactGatgtggtgttgctctctgtc	5	15	8	13	0	1	1	0	1	1	0	5	1	3	1	4	1	1	3	4	1	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:9087482G>A	uc001mhh.1	-	7	886	c.806C>T	c.(805-807)TCA>TTA	p.S269L	SCUBE2_uc001mhi.1_Missense_Mutation_p.S269L|SCUBE2_uc001mhj.1_Missense_Mutation_p.S269L	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	269						extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		ATCCACCACTGATGTGGTGTT	0.522													14	43					0	0	0	0	A	9087482	A	A	9087482	3	1	214	1	0	0	0	0	1	0	0	0	14010	1294	45	2	2348	2	SCUBE2	11	9087482	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1078643	9087482	125919034	332	39222											
EIF4G2	1982	broad.mit.edu	37	chr11	10828424	10828424	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccctacttcctcctccgcccGaagaagcactatttaaaaga	12	9	5	15	2	0	2	0	0	0	2	3	3	3	2	5	0	2	1	5	0	6	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:10828424G>C	uc001mjc.2	-	3	467	c.50C>G	c.(49-51)TCG>TGG	p.S17W	EIF4G2_uc001mjb.2_5'UTR|EIF4G2_uc009ygf.2_5'UTR|EIF4G2_uc001mjd.2_Missense_Mutation_p.S17W|EIF4G2_uc001mjf.1_5'UTR	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	17					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TCCTCCGCCCGAAGAAGCACT	0.358													27	94					0	0	0	0	C	10828424	C	C	10828424	3	2	214	1	0	0	0	0	1	0	0	0	5061	1059	37	3	2753	3	EIF4G2	11	10828424	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1740942	10828424	124178092	333	39223											
SPON1	10418	broad.mit.edu	37	chr11	14280917	14280917	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtcccgggagaggtatgtGaagcagttcccggaggacgg	9	6	18	8	3	0	2	0	1	0	1	2	5	2	4	2	6	1	3	2	6	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:14280917G>A	uc001mle.2	+	13	2122	c.1584G>A	c.(1582-1584)GTG>GTA	p.V528V		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	528	TSP type-1 2.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		AGAGGTATGTGAAGCAGTTCC	0.652													3	13					0	0	0	0	A	14280917	A	A	14280917	2	1	214	1	0	0	0	0	0	0	0	1	15148	1277	45	2		2	SPON1	11	14280917	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3452493	14280917	120725599	334	39224											
COPB1	1315	broad.mit.edu	37	chr11	14486569	14486569	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacggcttttccacaagtttCagatcccctgaaagaaagag	13	9	9	10	1	1	4	1	1	0	3	3	5	3	4	3	1	0	2	3	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:14486569C>T	uc001mli.2	-	18	2605	c.2298G>A	c.(2296-2298)CTG>CTA	p.L766L	COPB1_uc001mlg.2_Silent_p.L766L|COPB1_uc001mlh.2_Silent_p.L766L	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	766					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						CCACAAGTTTCAGATCCCCTG	0.274													10	18					0	0	0	0	T	14486569	T	T	14486569	2	4	214	1	0	0	0	0	0	0	0	1	3743	813	29	2		2	COPB1	11	14486569	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	205652	14486569	120519947	335	39225											
COPB1	1315	broad.mit.edu	37	chr11	14507935	14507935	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgattgcagttggtgcactaGagagtgtcactaatgtccca	10	12	11	8	0	1	2	1	1	0	1	2	3	2	2	1	1	2	3	1	1	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:14507935G>C	uc001mli.2	-	7	1122	c.815C>G	c.(814-816)TCT>TGT	p.S272C	COPB1_uc001mlg.2_Missense_Mutation_p.S272C|COPB1_uc001mlh.2_Missense_Mutation_p.S272C	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	272	HEAT 3.				COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						TGGTGCACTAGAGAGTGTCAC	0.398													12	93					0	0	0	0	C	14507935	C	C	14507935	3	2	214	1	0	0	0	0	1	0	0	0	3743	942	33	2	2110	2	COPB1	11	14507935	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	21366	14507935	120498581	336	39226											
SAAL1	113174	broad.mit.edu	37	chr11	18105261	18105261	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagacccgaatgaggctgtCaattagaggaagatctactg	14	9	11	7	1	2	4	1	1	1	3	2	6	2	5	1	2	1	1	1	2	6	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:18105261C>T	uc001mnq.2	-	10	1110	c.1060G>A	c.(1060-1062)GAC>AAC	p.D354N	SAAL1_uc001mnr.2_Missense_Mutation_p.D353N|SAAL1_uc001mns.2_RNA|SAAL1_uc009yhf.2_Missense_Mutation_p.D356N	NM_138421	NP_612430	Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	354					acute-phase response	extracellular region	binding				0						ATGAGGCTGTCAATTAGAGGA	0.318													4	30					0	0	0	0	T	18105261	T	T	18105261	3	4	214	1	0	0	0	0	1	0	0	0	13866	826	29	2	376	2	SAAL1	11	18105261	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3597326	18105261	116901255	337	39227											
CCDC34	91057	broad.mit.edu	37	chr11	27384432	27384432	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggctcgccactttggcctCtgaatcatgggcatcttcat	7	12	9	13	1	4	1	2	1	2	0	5	1	4	1	2	3	0	2	2	3	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:27384432C>G	uc001mrh.1	-	1	364	c.310G>C	c.(310-312)GAG>CAG	p.E104Q	CCDC34_uc001mri.1_Missense_Mutation_p.E104Q	NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	104											0						ACTTTGGCCTCTGAATCATGG	0.572													27	81					0	0	0	0	G	27384432	G	G	27384432	3	3	214	1	0	0	0	0	1	0	0	0	2820	922	32	2	919	2	CCDC34	11	27384432	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	9279171	27384432	107622084	338	39228											
C11orf41	25758	broad.mit.edu	37	chr11	33566371	33566371	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgccgtcacattgtttctGaggaaatcaagtccacctgc	9	11	9	12	1	3	1	2	1	1	0	4	2	4	2	3	1	2	2	3	1	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:33566371G>A	uc001mup.3	+	2	2083	c.1959G>A	c.(1957-1959)CTG>CTA	p.L653L	C11orf41_uc001mun.1_Silent_p.L653L	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	647						integral to membrane				ovary(2)	2						CATTGTTTCTGAGGAAATCAA	0.512													8	17					0	0	0	0	A	33566371	A	A	33566371	2	1	214	1	0	0	0	0	0	0	0	1	1646	1277	45	2		2	C11orf41	11	33566371	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6181939	33566371	101440145	339	39229											
CAPRIN1	4076	broad.mit.edu	37	chr11	34107680	34107680	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagagccccactctttgactCcagtggctcaggcagatccc	8	8	9	16	0	2	3	1	1	1	2	4	3	4	3	4	2	1	2	4	2	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:34107680C>G	uc001mvh.1	+	10	1225	c.1036C>G	c.(1036-1038)CCA>GCA	p.P346A	CAPRIN1_uc001mvg.2_Missense_Mutation_p.P346A|CAPRIN1_uc001mvi.2_Missense_Mutation_p.P346A|CAPRIN1_uc001mvj.1_Missense_Mutation_p.P265A	NM_005898	NP_005889	Q14444	CAPR1_HUMAN	membrane component chromosome 11 surface marker	346					negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				CTCTTTGACTCCAGTGGCTCA	0.458													5	48					0	0	0	0	G	34107680	G	G	34107680	3	3	214	1	0	0	0	0	1	0	0	0	2647	855	30	2	1070	2	CAPRIN1	11	34107680	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	541309	34107680	100898836	340	39230											
ALKBH3	221120	broad.mit.edu	37	chr11	43911373	43911373	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaacagaggactggcatcaGagagggtaagtagatcccag	15	5	14	7	0	1	3	1	0	0	3	2	6	2	4	1	3	1	3	1	3	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:43911373G>C	uc001mxs.2	+	6	808	c.365G>C	c.(364-366)AGA>ACA	p.R122T	ALKBH3_uc009ykp.2_RNA|ALKBH3_uc001mxt.2_RNA|ALKBH3_uc009ykq.2_5'UTR	NM_139178	NP_631917	Q96Q83	ALKB3_HUMAN	AlkB homolog 3	122				R->A: Decreases activity towards ssDNA by 25%. Loss of activity towards dsDNA.	DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation	mitochondrion|nucleoplasm	damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	ACTGGCATCAGAGAGGGTAAG	0.478								Direct_reversal_of_damage					11	31					0	0	0	0	C	43911373	C	C	43911373	3	2	214	1	0	0	0	0	1	0	0	0	528	942	33	2	383	2	ALKBH3	11	43911373	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9803693	43911373	91095143	341	39231											
PRDM11	56981	broad.mit.edu	37	chr11	45241256	45241256	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtacagcgaggactacatGaagcgcctgcacagcatgtc	11	7	12	11	2	0	1	0	1	0	0	1	3	0	2	1	2	6	3	1	2	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:45241256G>A	uc001myo.2	+	7	1041	c.792G>A	c.(790-792)ATG>ATA	p.M264I		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	264	SET.									upper_aerodigestive_tract(1)	1						AGGACTACATGAAGCGCCTGC	0.637													13	31					0	0	0	0	A	45241256	A	A	45241256	3	1	214	1	0	0	0	0	1	0	0	0	12514	1290	45	2	814	2	PRDM11	11	45241256	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1329883	45241256	89765260	342	39232											
OR4A47	403253	broad.mit.edu	37	chr11	48510865	48510866	+	Frame_Shift_Ins	INS	-	T	T																															ggccccaatgtcattgatcaINSttttttctgtgacatgtatc																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:48510865_48510866insT	uc010rhx.1	+	1	521_522	c.521_522insT	c.(520-522)CATfs	p.H174fs		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GTCATTGATCATTTTTTCTGTG	0.465													---	---	---								T	48510866	T	T	48510865	7	5	214	1	0	1	1	0	0	0	0	0	11096	217	8	0	523	0	OR4A47	11	48510865	Frame_Shift_Ins	INS	-	TCGA-CV-6961-01A-21D-1912-08	3269609	48510865	86495651	343	39233											
TNKS1BP1	85456	broad.mit.edu	37	chr11	57069957	57069957	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgaaggagaagtcctgactGggggatctggcaggagggcc	10	6	18	7	0	1	3	0	2	1	1	2	6	2	5	2	6	0	1	2	6	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:57069957G>A	uc001njr.2	-	6	4971	c.4659C>T	c.(4657-4659)CCC>CCT	p.P1553P	TNKS1BP1_uc001njp.2_Silent_p.P125P|TNKS1BP1_uc001njq.2_Silent_p.P125P|TNKS1BP1_uc001njs.2_Silent_p.P1553P	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1553	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				AGTCCTGACTGGGGGATCTGG	0.637													5	20					0	0	0	0	A	57069957	A	A	57069957	2	1	214	1	0	0	0	0	0	0	0	1	16386	1335	47	4		4	TNKS1BP1	11	57069957	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	8559092	57069957	77936559	344	39234											
FAM111A	63901	broad.mit.edu	37	chr11	58919875	58919875	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgattggaaactcattgaaaAcaatgacaccattttagaaa	18	11	6	6	0	1	4	1	3	0	1	1	5	1	5	1	1	2	0	1	1	6	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:58919875A>G	uc010rkp.1	+	5	961	c.734A>G	c.(733-735)AAC>AGC	p.N245S	FAM111A_uc010rkq.1_Missense_Mutation_p.N245S|FAM111A_uc010rkr.1_Missense_Mutation_p.N245S|FAM111A_uc001nno.2_Missense_Mutation_p.N245S|FAM111A_uc001nnp.2_Missense_Mutation_p.N245S|FAM111A_uc001nnq.2_Missense_Mutation_p.N245S	NM_001142521	NP_001135993	Q96PZ2	F111A_HUMAN	hypothetical protein LOC63901	245					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_epithelial(135;0.139)				CTCATTGAAAACAATGACACC	0.418													15	73					0	0	0	0	G	58919875	G	G	58919875	3	3	214	1	0	0	0	0	1	0	0	0	5427	43	2	5	740	5	FAM111A	11	58919875	Missense_Mutation	SNP	A	TCGA-CV-6961-01A-21D-1912-08	1849918	58919875	76086641	345	39235											
DTX4	23220	broad.mit.edu	37	chr11	58972245	58972245	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagacaccgtcatctggaatGaggtccaccacaagacagag	14	5	10	12	1	2	4	1	1	1	3	3	5	3	5	3	2	0	0	3	2	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:58972245G>A	uc001nns.2	+	9	1980	c.1723G>A	c.(1723-1725)GAG>AAG	p.E575K	DTX4_uc001nnr.2_Missense_Mutation_p.E469K	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	575					Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				CATCTGGAATGAGGTCCACCA	0.562													4	18					0	0	0	0	A	58972245	A	A	58972245	3	1	214	1	0	0	0	0	1	0	0	0	4819	1291	45	2	1757	2	DTX4	11	58972245	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	52370	58972245	76034271	346	39236											
OR4D9	390199	broad.mit.edu	37	chr11	59283051	59283051	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatcttacacggtcatcttGatgatgctgaggtctcacac	10	13	8	10	1	4	3	2	3	3	0	5	3	4	3	0	2	2	1	0	2	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:59283051G>C	uc010rkv.1	+	1	666	c.666G>C	c.(664-666)TTG>TTC	p.L222F		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CGGTCATCTTGATGATGCTGA	0.498													27	156					0	0	0	0	C	59283051	C	C	59283051	3	2	214	1	0	0	0	0	1	0	0	0	11113	1281	45	2	668	2	OR4D9	11	59283051	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	310806	59283051	75723465	347	39237											
C11orf9	745	broad.mit.edu	37	chr11	61548770	61548770	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaccctggccatgttctcagCccaagtcccagccccagcac	9	6	7	19	0	1	0	1	0	1	0	3	0	2	0	6	1	4	2	6	1	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:61548770C>T	uc001nsc.1	+	21	2829	c.2733C>T	c.(2731-2733)AGC>AGT	p.S911S	C11orf9_uc001nse.1_Silent_p.S876S|C11orf9_uc010rll.1_Silent_p.S302S	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	911					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						atgttctcagcccaagtccca	0.353													18	47					0	0	0	0	T	61548770	T	T	61548770	2	4	214	1	0	0	0	0	0	0	0	1	1677	738	26	4		4	C11orf9	11	61548770	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2265719	61548770	73457746	348	39238											
LGALS12	85329	broad.mit.edu	37	chr11	63283183	63283183	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttacccccagagattctttGaggtaggtcagagccaaatg	11	11	10	9	0	2	3	1	1	1	2	2	4	2	3	3	2	2	1	3	2	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:63283183G>A	uc001nxa.2	+	8	1203	c.862G>A	c.(862-864)GAG>AAG	p.E288K	LGALS12_uc001nxb.2_Missense_Mutation_p.E279K|LGALS12_uc001nxc.2_Missense_Mutation_p.E289K|LGALS12_uc001nxd.2_Missense_Mutation_p.E227K|LGALS12_uc001nxe.2_Missense_Mutation_p.E218K|LGALS12_uc009yot.2_Missense_Mutation_p.E248K	NM_033101	NP_149092	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12 isoform	288	Galectin 2.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			ovary(2)	2						GAGATTCTTTGAGGTAGGTCA	0.557													11	37					0	0	0	0	A	63283183	A	A	63283183	3	1	214	1	0	0	0	0	1	0	0	0	8779	1291	45	2	895	2	LGALS12	11	63283183	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1734413	63283183	71723333	349	39239											
C11orf84	144097	broad.mit.edu	37	chr11	63581231	63581231	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatgcgaggaaggggaggacGaggaggaggccatggtggtg	11	4	22	4	2	0	0	0	0	0	0	0	7	0	5	1	9	1	0	1	9	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:63581231G>A	uc001nxt.2	+	1	309	c.73G>A	c.(73-75)GAG>AAG	p.E25K		NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	25											0						AGGGGAGGACGAGGAGGAGGC	0.677													9	29					0	0	0	0	A	63581231	A	A	63581231	3	1	214	1	0	0	0	0	1	0	0	0	1673	1059	37	1	75	1	C11orf84	11	63581231	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	298048	63581231	71425285	350	39240											
FERMT3	83706	broad.mit.edu	37	chr11	63990903	63990903	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgacgcgggagcgggcccGtggggaggagctggatgaag	7	4	22	8	5	0	1	0	1	0	0	1	6	0	5	1	6	2	1	1	6	1	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:63990903G>A	uc001nyl.2	+	15	2092	c.1943G>A	c.(1942-1944)CGT>CAT	p.R648H	FERMT3_uc001nym.2_Missense_Mutation_p.R644H|NUDT22_uc009ypd.2_5'Flank|NUDT22_uc001nyp.3_5'Flank|NUDT22_uc009ype.2_5'Flank|NUDT22_uc001nyq.3_5'Flank	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	648					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						GAGCGGGCCCGTGGGGAGGAG	0.612													8	42					0	0	0	0	A	63990903	A	A	63990903	3	1	214	1	0	0	0	0	1	0	0	0	5851	1145	40	1	1997	1	FERMT3	11	63990903	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	409672	63990903	71015613	351	39241											
ESRRA	2101	broad.mit.edu	37	chr11	64082296	64082296	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctgaccccgcaggccctGatgggcacctcccagccgtg	5	6	12	18	2	0	2	0	2	0	0	1	2	1	2	7	2	2	2	7	2	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:64082296G>A	uc001nzq.1	+	5	832	c.655G>A	c.(655-657)GAT>AAT	p.D219N	ESRRA_uc001nzr.1_Missense_Mutation_p.D218N|ESRRA_uc001nzs.1_Missense_Mutation_p.D219N|ESRRA_uc009ypn.1_Intron	NM_004451	NP_004442	P11474	ERR1_HUMAN	estrogen-related receptor alpha	219	Ligand binding domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0						CGCAGGCCCTGATGGGCACCT	0.587													17	50					0	0	0	0	A	64082296	A	A	64082296	3	1	214	1	0	0	0	0	1	0	0	0	5284	1290	45	2	669	2	ESRRA	11	64082296	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	91393	64082296	70924220	352	39242											
AIP	9049	broad.mit.edu	37	chr11	67254633	67254633	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgcgagaaggggagattGcccagttcctctgtgacatc	9	9	12	11	1	1	3	0	1	1	2	3	5	2	3	3	2	2	1	3	2	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:67254633G>C	uc001olv.2	+	2	381	c.256G>C	c.(256-258)GCC>CCC	p.A86P		NM_003977	NP_003968	O00170	AIP_HUMAN	aryl hydrocarbon receptor interacting protein	86	PPIase FKBP-type.				protein maturation by protein folding|protein targeting to mitochondrion	nucleus	signal transducer activity|transcription coactivator activity|transcription factor binding|unfolded protein binding				0						AGGGGAGATTGCCCAGTTCCT	0.582									Familial_Isolated_Pituitary_Adenoma_				11	129					0	0	0	0	C	67254633	C	C	67254633	3	2	214	1	0	0	0	0	1	0	0	0	435	1319	46	4	262	4	AIP	11	67254633	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3172337	67254633	67751883	353	39243											
ARAP1	116985	broad.mit.edu	37	chr11	72409008	72409008	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcttcgcagggcccctccggGaagacagcacggagctccga	8	5	13	15	4	1	1	0	0	1	1	4	4	3	3	4	3	2	3	4	3	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:72409008G>A	uc001osu.2	-	19	2874	c.2685C>T	c.(2683-2685)TTC>TTT	p.F895F	ARAP1_uc001osv.2_Silent_p.F895F|ARAP1_uc001osr.2_Silent_p.F655F|ARAP1_uc001oss.2_Silent_p.F650F|ARAP1_uc009yth.2_Silent_p.F589F|ARAP1_uc010rre.1_Silent_p.F650F|ARAP1_uc001osw.1_Silent_p.F183F	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	895					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						GCCCCTCCGGGAAGACAGCAC	0.657													3	21					0	0	0	0	A	72409008	A	A	72409008	2	1	214	1	0	0	0	0	0	0	0	1	838	1165	41	2		2	ARAP1	11	72409008	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5154375	72409008	62597508	354	39244											
RNF169	254225	broad.mit.edu	37	chr11	74546869	74546869	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgctaagtcctctcatcatCaaatcaactccacgcaacct	12	10	4	15	1	4	0	4	0	1	0	7	0	6	0	3	0	3	2	3	0	4	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:74546869C>G	uc001ovl.3	+	6	1234	c.1221C>G	c.(1219-1221)ATC>ATG	p.I407M	XRRA1_uc001ovm.2_Intron	NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	407							zinc ion binding			ovary(1)	1						CTCTCATCATCAAATCAACTC	0.493													38	120					0	0	0	0	G	74546869	G	G	74546869	3	3	214	1	0	0	0	0	1	0	0	0	13525	816	29	2	1243	2	RNF169	11	74546869	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2137861	74546869	60459647	355	39245											
PRKRIR	5612	broad.mit.edu	37	chr11	76062393	76062393	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagagataagcatttaagagCtttgaggtgctgttctgaga	12	12	12	5	0	1	4	0	2	1	3	1	6	1	4	0	1	3	4	0	1	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:76062393C>T	uc001oxh.1	-	5	1801	c.1801G>A	c.(1801-1803)GCT>ACT	p.A601T	PRKRIR_uc010rrz.1_Missense_Mutation_p.A426T	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	601					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						CATTTAAGAGCTTTGAGGTGC	0.413													37	89					0	0	0	0	T	76062393	T	T	76062393	3	4	214	1	0	0	0	0	1	0	0	0	12588	797	28	4	488	4	PRKRIR	11	76062393	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1515524	76062393	58944123	356	39246											
MYO7A	4647	broad.mit.edu	37	chr11	76873901	76873901	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccctccactccccagggCacagacaccaccatgttaca	10	6	6	19	0	0	1	0	0	0	1	2	1	2	1	7	1	2	2	7	1	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:76873901C>T	uc001oyb.2	+	14	1829	c.1557C>T	c.(1555-1557)GGC>GGT	p.G519G	MYO7A_uc010rsl.1_Silent_p.G519G|MYO7A_uc010rsm.1_Silent_p.G508G|MYO7A_uc001oyc.2_Silent_p.G519G	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	519	Myosin head-like.		G -> D (in USH1B; the deleterious effect remains to be proven).		actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CTCCCCAGGGCACAGACACCA	0.597													38	87					0	0	0	0	T	76873901	T	T	76873901	2	4	214	1	0	0	0	0	0	0	0	1	10135	697	25	4		4	MYO7A	11	76873901	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	811508	76873901	58132615	357	39247											
USP35	57558	broad.mit.edu	37	chr11	77920693	77920693	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggccttcacggacctctctCtcgccttccctcctcctgag	4	11	7	19	2	3	1	1	1	2	0	8	2	6	2	6	2	0	0	6	2	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:77920693C>G	uc009yva.1	+	10	2038	c.1792C>G	c.(1792-1794)CTC>GTC	p.L598V	USP35_uc001oze.2_Missense_Mutation_p.L354V|USP35_uc001ozc.2_Missense_Mutation_p.L166V|USP35_uc010rsp.1_Missense_Mutation_p.L30V|USP35_uc001ozd.2_Missense_Mutation_p.L209V|USP35_uc001ozf.2_Missense_Mutation_p.L329V	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	598					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			GGACCTCTCTCTCGCCTTCCC	0.622													10	132					0	0	0	0	G	77920693	G	G	77920693	3	3	214	1	0	0	0	0	1	0	0	0	17134	913	32	2	1826	2	USP35	11	77920693	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1046792	77920693	57085823	358	39248											
ZC3H12C	85463	broad.mit.edu	37	chr11	110023720	110023720	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttggaaagaggccacaaaGacattacagtttttgttcct	12	14	8	7	0	0	2	0	0	0	2	1	3	1	3	2	2	1	2	2	2	3	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:110023720G>C	uc009yxw.2	+	3	901	c.850G>C	c.(850-852)GAC>CAC	p.D284H	ZC3H12C_uc010rwc.1_Missense_Mutation_p.D285H|ZC3H12C_uc010rwd.1_Missense_Mutation_p.D285H|ZC3H12C_uc001pkr.3_Missense_Mutation_p.D253H|ZC3H12C_uc001pkq.2_Missense_Mutation_p.D253H	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	284							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		AGGCCACAAAGACATTACAGT	0.428													3	7					0	0	0	0	C	110023720	C	C	110023720	3	2	214	1	0	0	0	0	1	0	0	0	17630	942	33	2	860	2	ZC3H12C	11	110023720	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	32103027	110023720	24982796	359	39249											
IL10RA	3587	broad.mit.edu	37	chr11	117860224	117860224	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcctatgaccttaccgcaGtgaccttggacctgtaccac	8	11	8	14	1	0	2	0	2	0	0	1	3	1	3	6	1	2	2	6	1	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:117860224G>A	uc001prv.2	+	3	333	c.256G>A	c.(256-258)GTG>ATG	p.V86M	IL10RA_uc010rxl.1_Missense_Mutation_p.V66M|IL10RA_uc010rxm.1_Missense_Mutation_p.V66M|IL10RA_uc010rxn.1_Intron|IL10RA_uc001prw.2_Translation_Start_Site	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	86	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CCTTACCGCAGTGACCTTGGA	0.577													28	37					0	0	0	0	A	117860224	A	A	117860224	3	1	214	1	0	0	0	0	1	0	0	0	7659	1029	36	4	266	4	IL10RA	11	117860224	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	7836504	117860224	17146292	360	39250											
ARCN1	372	broad.mit.edu	37	chr11	118453900	118453900	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtccacgcttagatccctGaatattgccgagccttagaa	10	11	9	11	2	0	3	0	1	0	2	2	4	2	3	4	0	2	1	4	0	5	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:118453900G>A	uc001ptq.2	+	3	435	c.274G>A	c.(274-276)GAA>AAA	p.E92K	ARCN1_uc009zah.2_Intron|ARCN1_uc010ryg.1_Missense_Mutation_p.E4K|ARCN1_uc009zag.2_Missense_Mutation_p.E133K	NM_001655	NP_001646	P48444	COPD_HUMAN	archain isoform 1	92					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TTAGATCCCTGAATATTGCCG	0.348													35	53					0	0	0	0	A	118453900	A	A	118453900	3	1	214	1	0	0	0	0	1	0	0	0	842	1291	45	2	284	2	ARCN1	11	118453900	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	593676	118453900	16552616	361	39251											
OR10G4	390264	broad.mit.edu	37	chr11	123886938	123886938	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atagtgctgtcctatgtgtcCatcgtctgttccatcctgcg	5	15	9	12	2	1	0	0	0	1	0	6	0	5	0	4	0	2	2	4	0	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:123886938C>A	uc010sac.1	+	1	657	c.657C>A	c.(655-657)TCC>TCA	p.S219S		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	219	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CCTATGTGTCCATCGTCTGTT	0.542													36	60					5.8336e-16	6.37796e-16	1	0	A	123886938	A	A	123886938	2	1	214	1	0	0	0	0	0	0	0	1	10955	581	21	4		4	OR10G4	11	123886938	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5433038	123886938	11119578	362	39252											
TMEM45B	120224	broad.mit.edu	37	chr11	129724648	129724648	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgttgacatgctcacctatCtggtcagccacgttcccttg	6	14	8	13	1	3	1	2	1	1	0	4	1	4	1	3	1	2	3	3	1	1	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr11:129724648C>G	uc001qfe.1	+	3	383	c.322C>G	c.(322-324)CTG>GTG	p.L108V	TMEM45B_uc001qff.1_Missense_Mutation_p.L108V	NM_138788	NP_620143	Q96B21	TM45B_HUMAN	transmembrane protein 45B	108	Helical; (Potential).					integral to membrane					0	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)		GCTCACCTATCTGGTCAGCCA	0.483													29	40					0	0	0	0	G	129724648	G	G	129724648	3	3	214	1	0	0	0	0	1	0	0	0	16236	912	32	2	328	2	TMEM45B	11	129724648	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5837710	129724648	5281868	363	39253											
B4GALNT3	283358	broad.mit.edu	37	chr12	662840	662840	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gatgcggcctcaggcccctgGaaggggctggcatggggagg	6	5	20	10	1	1	0	1	0	0	0	1	3	1	2	3	9	1	2	3	9	1	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:662840G>A	uc001qii.1	+	14	1751	c.1751G>A	c.(1750-1752)GGA>GAA	p.G584E	B4GALNT3_uc001qij.1_Missense_Mutation_p.G487E|B4GALNT3_uc001qik.1_Missense_Mutation_p.G133E	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	584	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			CAGGCCCCTGGAAGGGGCTGG	0.517													9	36					0	0	0	0	A	662840	A	A	662840	3	1	214	1	0	0	0	0	1	0	0	0	1270	1174	41	2	1805	2	B4GALNT3	12	662840	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08		662840	133189055	364	39254											
AKAP3	10566	broad.mit.edu	37	chr12	4736776	4736776	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttcagaatacattttttctCtcaatttagtttcagatttc	10	20	4	7	0	4	2	3	0	1	2	6	2	4	2	0	0	1	2	0	0	4	9			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:4736776C>G	uc001qnb.3	-	4	1521	c.1292G>C	c.(1291-1293)AGA>ACA	p.R431T		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	431					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						CATTTTTTCTCTCAATTTAGT	0.408													21	108					0	0	0	0	G	4736776	G	G	4736776	3	3	214	1	0	0	0	0	1	0	0	0	452	913	32	2	1277	2	AKAP3	12	4736776	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4073936	4736776	129115119	365	39255											
LTBR	4055	broad.mit.edu	37	chr12	6499994	6499994	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctggccctcccgggctctCtacaccccaccaggaagatg	7	6	9	19	1	1	1	0	0	1	1	3	2	2	2	6	3	1	1	6	3	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:6499994C>G	uc001qny.1	+	10	1367	c.1199C>G	c.(1198-1200)TCT>TGT	p.S400C	LTBR_uc010sfc.1_Missense_Mutation_p.S381C|LTBR_uc001qnz.1_Missense_Mutation_p.S395C	NM_002342	NP_002333	P36941	TNR3_HUMAN	lymphotoxin beta receptor precursor	400	Cytoplasmic (Potential).				apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			lung(2)	2						CCCGGGCTCTCTACACCCCAC	0.632													56	123					0	0	0	0	G	6499994	G	G	6499994	3	3	214	1	0	0	0	0	1	0	0	0	9127	913	32	2	1237	2	LTBR	12	6499994	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1763218	6499994	127351901	366	39256											
C12orf57	113246	broad.mit.edu	37	chr12	7054986	7054986	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacgaagcccaggatcctgaGatcgccagcctgtcaggcaa	11	6	11	13	2	1	1	1	1	0	1	3	4	2	2	4	2	3	1	4	2	3	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:7054986G>A	uc001qrz.2	+	3	364	c.282G>A	c.(280-282)GAG>GAA	p.E94E	PTPN6_uc001qsa.1_5'Flank|PTPN6_uc010sfr.1_5'Flank	NM_138425	NP_612434	Q99622	C10_HUMAN	C10 protein	94											0						AGGATCCTGAGATCGCCAGCC	0.617													8	26					0	0	0	0	A	7054986	A	A	7054986	2	1	214	1	0	0	0	0	0	0	0	1	1707	933	33	2		2	C12orf57	12	7054986	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	554992	7054986	126796909	367	39257											
C1RL	51279	broad.mit.edu	37	chr12	7260991	7260991	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgggtacccgggggatgtCagctgctggggtagctcttg	4	11	17	9	1	3	0	1	0	2	0	3	1	3	1	1	5	4	5	1	5	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:7260991C>T	uc001qsn.2	-	2	173	c.156G>A	c.(154-156)CTG>CTA	p.L52L	C1RL_uc009zft.2_Silent_p.L52L|C1RL_uc001qso.1_Silent_p.L52L|LOC283314_uc001qsp.2_RNA|LOC283314_uc010sgb.1_5'Flank	NM_016546	NP_057630	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	52	CUB.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			pancreas(1)	1						CGGGGGATGTCAGCTGCTGGG	0.632													18	55					0	0	0	0	T	7260991	T	T	7260991	2	4	214	1	0	0	0	0	0	0	0	1	1982	813	29	2		2	C1RL	12	7260991	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	206005	7260991	126590904	368	39258											
KLRC3	3823	broad.mit.edu	37	chr12	10570960	10570960	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccatttcttcttcattatCtatacaaagcagactagaag	14	14	4	9	0	4	2	1	0	3	2	4	2	4	2	1	0	3	1	1	0	7	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:10570960C>G	uc001qyf.2	-	4	514	c.469G>C	c.(469-471)GAT>CAT	p.D157H	KLRC3_uc001qyh.2_Missense_Mutation_p.D157H|KLRC3_uc001qyi.1_Missense_Mutation_p.D157H|KLRC3_uc010shc.1_Nonstop_Mutation_p.*140Y|KLRC3_uc010shd.1_3'UTR	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	157	C-type lectin.|Extracellular (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						TCTTCATTATCTATACAAAGC	0.323													29	84					0	0	0	0	G	10570960	G	G	10570960	3	3	214	1	0	0	0	0	1	0	0	0	8456	913	32	2	365	2	KLRC3	12	10570960	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3309969	10570960	123280935	369	39259											
C12orf69	440087	broad.mit.edu	37	chr12	14959195	14959195	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgttaattatgccagttgtGacatttgagcccacaagttt	10	16	8	7	0	0	2	0	2	0	0	0	2	0	2	2	0	2	3	2	0	3	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:14959195G>A	uc001rck.1	-	2	493	c.420C>T	c.(418-420)GTC>GTT	p.V140V	WBP11_uc001rci.2_5'Flank|C12orf60_uc001rcj.3_Intron	NM_001013698	NP_001013720	A2RU48	CL069_HUMAN	hypothetical protein LOC440087	140						integral to membrane					0						TGCCAGTTGTGACATTTGAGC	0.438													5	110					0	0	0	0	A	14959195	A	A	14959195	2	1	214	1	0	0	0	0	0	0	0	1	1717	1277	45	2		2	C12orf69	12	14959195	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4388235	14959195	118892700	370	39260											
PDE3A	5139	broad.mit.edu	37	chr12	20799804	20799804	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccttggagttgatggcgCtgtatgtggctgcagccatg	5	12	15	9	1	0	1	0	1	0	0	0	2	0	2	2	3	3	5	2	3	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:20799804C>A	uc001reh.1	+	12	2507	c.2485C>A	c.(2485-2487)CTG>ATG	p.L829M		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	829	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GTTGATGGCGCTGTATGTGGC	0.428													33	126					1.62565e-12	1.76262e-12	1	0	A	20799804	A	A	20799804	3	1	214	1	0	0	0	0	1	0	0	0	11691	796	28	4	2531	4	PDE3A	12	20799804	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5840609	20799804	113052091	371	39261											
SLCO1B1	10599	broad.mit.edu	37	chr12	21358889	21358889	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaagtcaatgggaaccagtCtgtggaaacaatggaataac	17	7	11	6	0	2	0	1	0	1	0	2	4	2	3	1	3	3	0	1	3	7	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:21358889C>G	uc001req.3	+	11	1523	c.1419C>G	c.(1417-1419)GTC>GTG	p.V473V		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	473	Extracellular (Potential).|Kazal-like.				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	GGGAACCAGTCTGTGGAAACA	0.368													11	82					0	0	0	0	G	21358889	G	G	21358889	2	3	214	1	0	0	0	0	0	0	0	1	14787	900	32	2		2	SLCO1B1	12	21358889	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	559085	21358889	112493006	372	39262											
SSPN	8082	broad.mit.edu	37	chr12	26377309	26377309	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatgtattcaattttctatGaaagtaagttgtgattgttc	12	18	7	4	0	2	2	1	2	1	0	3	2	2	2	0	0	0	4	0	0	5	9			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:26377309G>C	uc001rhe.2	+	2	463	c.363G>C	c.(361-363)ATG>ATC	p.M121I	SSPN_uc001rhd.2_Missense_Mutation_p.M18I|SSPN_uc009zjf.2_Missense_Mutation_p.M121I|SSPN_uc001rhf.3_Intron	NM_005086	NP_005077	Q14714	SSPN_HUMAN	sarcospan isoform 1	121	Cytoplasmic (Potential).				cell adhesion|muscle contraction	cell junction|dystrophin-associated glycoprotein complex|integral to plasma membrane|postsynaptic membrane|sarcolemma|transport vesicle					0	Colorectal(261;0.0847)					AATTTTCTATGAAAGTAAGTT	0.373													45	152					0	0	0	0	C	26377309	C	C	26377309	3	2	214	1	0	0	0	0	1	0	0	0	15254	1290	45	2	369	2	SSPN	12	26377309	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5018420	26377309	107474586	373	39263											
PPFIBP1	8496	broad.mit.edu	37	chr12	27834486	27834486	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cattttcctgtagtgacttgGatatgccatttgccaagtgg	8	15	10	8	0	0	1	0	1	0	0	1	2	1	2	3	2	2	1	3	2	3	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:27834486G>C	uc001ric.1	+	21	2298	c.1921G>C	c.(1921-1923)GAT>CAT	p.D641H	PPFIBP1_uc010sjr.1_Missense_Mutation_p.D472H|PPFIBP1_uc001rib.1_Missense_Mutation_p.D635H|PPFIBP1_uc001ria.2_Missense_Mutation_p.D610H|PPFIBP1_uc001rid.1_Missense_Mutation_p.D488H|PPFIBP1_uc001rif.1_Missense_Mutation_p.D148H	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	641					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					TAGTGACTTGGATATGCCATT	0.418													11	103					0	0	0	0	C	27834486	C	C	27834486	3	2	214	1	0	0	0	0	1	0	0	0	12368	1174	41	2	2023	2	PPFIBP1	12	27834486	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1457177	27834486	106017409	374	39264											
OVCH1	341350	broad.mit.edu	37	chr12	29649538	29649538	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctccaactactaattctaGagaagaatctagatcccacg	14	11	5	11	1	3	3	0	0	3	3	5	4	4	3	2	0	2	0	2	0	7	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:29649538G>C	uc001rix.1	-	2	134	c.134C>G	c.(133-135)TCT>TGT	p.S45C		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	45	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					ACTAATTCTAGAGAAGAATCT	0.413													40	90					0	0	0	0	C	29649538	C	C	29649538	3	2	214	1	0	0	0	0	1	0	0	0	11377	942	33	2	3378	2	OVCH1	12	29649538	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1815052	29649538	104202357	375	39265											
C12orf35	55196	broad.mit.edu	37	chr12	32135670	32135670	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctttcacaggcacgtaagaCtcagaagacagtattaaaag	16	8	9	8	1	2	3	2	0	0	3	2	3	2	3	0	1	0	4	0	1	5	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:32135670C>G	uc001rks.2	+	4	2195	c.1781C>G	c.(1780-1782)ACT>AGT	p.T594S		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	594										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			GCACGTAAGACTCAGAAGACA	0.358													11	16					0	0	0	0	G	32135670	G	G	32135670	3	3	214	1	0	0	0	0	1	0	0	0	1688	565	20	4	1783	4	C12orf35	12	32135670	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2486132	32135670	101716225	376	39266											
ARID2	196528	broad.mit.edu	37	chr12	46231439	46231439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggtgctatacatgctcacgGaaatgggagatgttgcttgc	10	11	13	7	1	1	1	1	0	0	1	1	3	1	2	0	3	5	4	0	3	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:46231439G>A	uc001ros.1	+	10	1279	c.1279G>A	c.(1279-1281)GAA>AAA	p.E427K	ARID2_uc001ror.2_Missense_Mutation_p.E427K|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_Missense_Mutation_p.E73K|ARID2_uc001rot.1_Missense_Mutation_p.E73K	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	427					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CATGCTCACGGAAATGGGAGA	0.378													18	39					0	0	0	0	A	46231439	A	A	46231439	3	1	214	1	0	0	0	0	1	0	0	0	915	1175	41	2	1317	2	ARID2	12	46231439	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	14095769	46231439	87620456	377	39267											
RAPGEF3	10411	broad.mit.edu	37	chr12	48143273	48143273	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtgcatcattcaccagaGccagctgtccaaaatcatct	11	9	9	12	0	4	1	3	0	1	1	5	1	5	1	3	2	3	2	3	2	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:48143273G>A	uc009zkp.2	-	9	1255	c.815C>T	c.(814-816)GCT>GTT	p.A272V	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Missense_Mutation_p.A272V|RAPGEF3_uc001rpz.3_Missense_Mutation_p.A314V|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Missense_Mutation_p.A326V|RAPGEF3_uc001rqb.3_Missense_Mutation_p.A314V	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	272					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		ATTCACCAGAGCCAGCTGTCC	0.498													9	62					0	0	0	0	A	48143273	A	A	48143273	3	1	214	1	0	0	0	0	1	0	0	0	13110	971	34	4	1906	4	RAPGEF3	12	48143273	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1911834	48143273	85708622	378	39268											
OR8S1	341568	broad.mit.edu	37	chr12	48920205	48920205	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgccatctcatgccaaactCaggttcccccatagagttga	10	9	7	15	1	2	2	2	1	1	1	4	2	3	2	5	1	2	2	5	1	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:48920205C>T	uc010slu.1	+	1	791	c.791C>T	c.(790-792)TCA>TTA	p.S264L		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATGCCAAACTCAGGTTCCCCC	0.498													24	72					0	0	0	0	T	48920205	T	T	48920205	3	4	214	1	0	0	0	0	1	0	0	0	11300	838	29	2	793	2	OR8S1	12	48920205	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	776932	48920205	84931690	379	39269											
CCNT1	904	broad.mit.edu	37	chr12	49088089	49088089	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcacttgtggtagaagttGacatgctcattaaacctgca	11	12	9	9	0	1	2	1	1	0	1	1	2	1	2	1	1	4	5	1	1	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:49088089G>A	uc001rse.1	-	9	1231	c.908C>T	c.(907-909)TCA>TTA	p.S303L	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.S18L	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	303					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						GGTAGAAGTTGACATGCTCAT	0.493													31	61					0	0	0	0	A	49088089	A	A	49088089	3	1	214	1	0	0	0	0	1	0	0	0	2949	1294	45	2	1276	2	CCNT1	12	49088089	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	167884	49088089	84763806	380	39270											
FKBP11	51303	broad.mit.edu	37	chr12	49315828	49315828	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttttggagactttgggtCtattggcctttctgtatagg	5	19	11	6	0	3	1	0	0	3	1	3	2	3	1	1	4	0	1	1	4	3	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:49315828C>G	uc001rsp.2	-	6	664	c.545G>C	c.(544-546)AGA>ACA	p.R182T	FKBP11_uc010sma.1_Missense_Mutation_p.R80T|FKBP11_uc001rsq.3_3'UTR	NM_016594	NP_057678	Q9NYL4	FKB11_HUMAN	FK506 binding protein 11 isoform 1 precursor	182					protein folding	integral to membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						GACTTTGGGTCTATTGGCCTT	0.408													7	104					0	0	0	0	G	49315828	G	G	49315828	3	3	214	1	0	0	0	0	1	0	0	0	5935	913	32	2	64	2	FKBP11	12	49315828	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	227739	49315828	84536067	381	39271											
PRPF40B	25766	broad.mit.edu	37	chr12	50035744	50035744	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgaggacttcgcccacgtCataagctttgacaagagggc	10	10	11	10	2	1	3	1	2	0	1	2	4	1	4	1	2	1	1	1	2	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:50035744C>T	uc001rur.1	+	18	1819	c.1755C>T	c.(1753-1755)GTC>GTT	p.V585V	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001rup.1_Silent_p.V607V|PRPF40B_uc001ruq.1_Silent_p.V572V|PRPF40B_uc001rus.1_Silent_p.V528V|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	585					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						TCGCCCACGTCATAAGCTTTG	0.597													31	78					0	0	0	0	T	50035744	T	T	50035744	2	4	214	1	0	0	0	0	0	0	0	1	12634	813	29	2		2	PRPF40B	12	50035744	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	719916	50035744	83816151	382	39272											
KRT5	3852	broad.mit.edu	37	chr12	52910942	52910942	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcctctggatcatccggttCatctcagagatctcatgctt	8	13	8	12	1	5	1	4	0	3	1	8	3	6	2	2	2	2	2	2	2	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:52910942C>G	uc001san.2	-	6	1330	c.1167G>C	c.(1165-1167)ATG>ATC	p.M389I	KRT5_uc009zmh.2_Missense_Mutation_p.M389I	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	389	Rod.|Coil 2.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCATCCGGTTCATCTCAGAGA	0.522													26	99					0	0	0	0	G	52910942	G	G	52910942	3	3	214	1	0	0	0	0	1	0	0	0	8518	826	29	2	621	2	KRT5	12	52910942	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2875198	52910942	80940953	383	39273											
OR6C6	283365	broad.mit.edu	37	chr12	55688558	55688558	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaccaatgggggaaatatGattaagaatccagttaccca	16	9	9	7	0	0	3	0	2	0	1	1	4	1	4	3	2	1	1	3	2	6	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:55688558G>A	uc010sph.1	-	1	459	c.459C>T	c.(457-459)ATC>ATT	p.I153I		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						GGGGAAATATGATTAAGAATC	0.418													8	49					0	0	0	0	A	55688558	A	A	55688558	2	1	214	1	0	0	0	0	0	0	0	1	11248	1280	45	2		2	OR6C6	12	55688558	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2777616	55688558	78163337	384	39274											
STAT2	6773	broad.mit.edu	37	chr12	56740694	56740694	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccagacatggtcttcttCagcagccggcgctcctggct	5	10	12	14	2	3	1	1	0	2	1	4	1	4	1	3	3	3	3	3	3	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:56740694C>A	uc001slc.2	-	20	1848	c.1770G>T	c.(1768-1770)CTG>CTT	p.L590L	STAT2_uc001slb.2_Silent_p.L132L|STAT2_uc001sld.2_Silent_p.L586L	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	590	SH2.				interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TGGTCTTCTTCAGCAGCCGGC	0.607													21	95					6.33239e-15	6.89448e-15	1	0	A	56740694	A	A	56740694	2	1	214	1	0	0	0	0	0	0	0	1	15331	813	29	2		2	STAT2	12	56740694	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1052136	56740694	77111201	385	39275											
NACA	4666	broad.mit.edu	37	chr12	57106570	57106570	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaaggcttgaacacttacCataatcgcatttacaatatc	16	11	4	10	1	0	1	0	1	0	0	2	1	0	1	1	1	3	2	1	1	7	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:57106570C>T	uc001slz.2	-	7	982	c.633G>A	c.(631-633)ATG>ATA	p.M211I	NACA_uc001sly.2_Missense_Mutation_p.M211I|NACA_uc009zoy.1_Missense_Mutation_p.M2074I|NACA_uc001smc.2_Missense_Mutation_p.M211I|NACA_uc001sma.2_Missense_Mutation_p.M921I|NACA_uc001smb.2_Missense_Mutation_p.M211I|NACA_uc010squ.1_RNA	NM_001113201	NP_001106672	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	211	UBA.				interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1						GAACACTTACCATAATCGCAT	0.403			T	BCL6	NHL								17	79					0	0	0	0	T	57106570	T	T	57106570	3	4	214	1	0	0	0	0	1	0	0	0	10186	608	21	4	22	4	NACA	12	57106570	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	365876	57106570	76745325	386	39276			2	58		5	5	1580	C		5.158723e-08
NACA	4666	broad.mit.edu	37	chr12	57106606	57106606	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatcattactgttgttcttCagggctcggactgcctttgc	6	16	9	10	1	3	0	2	0	1	0	4	1	3	1	1	2	3	3	1	2	2	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:57106606C>T	uc001slz.2	-	7	946	c.597G>A	c.(595-597)CTG>CTA	p.L199L	NACA_uc001sly.2_Silent_p.L199L|NACA_uc009zoy.1_Silent_p.L2062L|NACA_uc001smc.2_Silent_p.L199L|NACA_uc001sma.2_Silent_p.L909L|NACA_uc001smb.2_Silent_p.L199L|NACA_uc010squ.1_RNA	NM_001113201	NP_001106672	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	199	UBA.				interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1						TGTTGTTCTTCAGGGCTCGGA	0.423			T	BCL6	NHL								15	84					0	0	0	0	T	57106606	T	T	57106606	2	4	214	1	0	0	0	0	0	0	0	1	10186	813	29	2		2	NACA	12	57106606	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	36	57106606	76745289	387	39277			2	58		5	5	1580	C		5.158723e-08
NACA	4666	broad.mit.edu	37	chr12	57106659	57106659	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttgtgacatgaccaattCaatgtccttaacttctacac	11	14	5	11	0	2	2	1	2	1	0	3	2	3	2	2	0	3	1	2	0	4	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:57106659C>G	uc001slz.2	-	7	893	c.544G>C	c.(544-546)GAA>CAA	p.E182Q	NACA_uc001sly.2_Missense_Mutation_p.E182Q|NACA_uc009zoy.1_Missense_Mutation_p.E2045Q|NACA_uc001smc.2_Missense_Mutation_p.E182Q|NACA_uc001sma.2_Missense_Mutation_p.E892Q|NACA_uc001smb.2_Missense_Mutation_p.E182Q|NACA_uc010squ.1_RNA	NM_001113201	NP_001106672	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	182	UBA.				interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1						ATGACCAATTCAATGTCCTTA	0.403			T	BCL6	NHL								10	91					0	0	0	0	G	57106659	G	G	57106659	3	3	214	1	0	0	0	0	1	0	0	0	10186	835	29	2	111	2	NACA	12	57106659	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	53	57106659	76745236	388	39278			2	58		5	5	1580	C		5.158723e-08
NACA	4666	broad.mit.edu	37	chr12	57106861	57106861	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatacctcttcctcttcactCtcctcttgtacagttggagt	6	17	5	13	0	5	0	1	0	4	0	7	1	6	1	3	1	2	2	3	1	3	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:57106861C>G	uc001slz.2	-	6	844	c.495G>C	c.(493-495)GAG>GAC	p.E165D	NACA_uc001sly.2_Missense_Mutation_p.E165D|NACA_uc009zoy.1_Missense_Mutation_p.E2028D|NACA_uc001smc.2_Missense_Mutation_p.E165D|NACA_uc001sma.2_Missense_Mutation_p.E875D|NACA_uc001smb.2_Missense_Mutation_p.E165D|NACA_uc010squ.1_RNA	NM_001113201	NP_001106672	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	165					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1						CCTCTTCACTCTCCTCTTGTA	0.403			T	BCL6	NHL								7	41					0	0	0	0	G	57106861	G	G	57106861	3	3	214	1	0	0	0	0	1	0	0	0	10186	912	32	2	164	2	NACA	12	57106861	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	202	57106861	76745034	389	39279			2	58		5	5	1580	C		5.158723e-08
NACA	4666	broad.mit.edu	37	chr12	57108149	57108149	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccttttcaaatcttaccttCcgtgccttcttttcactccg	5	18	3	15	2	4	0	2	0	2	0	7	0	7	0	5	0	2	0	5	0	2	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:57108149C>A	uc001slz.2	-	4	580	c.231G>T	c.(229-231)CGG>CGT	p.R77R	NACA_uc001sly.2_Silent_p.R77R|NACA_uc009zoy.1_Silent_p.R1940R|NACA_uc001smc.2_Silent_p.R77R|NACA_uc001sma.2_Silent_p.R787R|NACA_uc001smb.2_Silent_p.R77R|NACA_uc010squ.1_Intron	NM_001113201	NP_001106672	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	77	Required for DNA-binding (By similarity).|NAC-A/B.				interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1						ATCTTACCTTCCGTGCCTTCT	0.328			T	BCL6	NHL								10	47					4.68919e-08	4.97434e-08	1	0	A	57108149	A	A	57108149	2	1	214	1	0	0	0	0	0	0	0	1	10186	842	30	2		2	NACA	12	57108149	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1288	57108149	76743746	390	39280			2	58		5	5	1580	C		5.158723e-08
NAB2	4665	broad.mit.edu	37	chr12	57484986	57484986	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcctgcagcgcgccaacctCctttcctactatgagacctt	7	11	7	16	2	0	1	0	1	0	1	3	2	3	1	6	0	4	1	6	0	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:57484986C>A	uc001smz.2	+	2	540	c.162C>A	c.(160-162)CTC>CTA	p.L54L		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	54	NCD1.				cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCGCCAACCTCCTTTCCTACT	0.632													25	102					7.88262e-20	8.69081e-20	1	0	A	57484986	A	A	57484986	2	1	214	1	0	0	0	0	0	0	0	1	10185	842	30	2		2	NAB2	12	57484986	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	376837	57484986	76366909	391	39281											
GLI1	2735	broad.mit.edu	37	chr12	57857788	57857788	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcttttttctaggactgtCtggcccgcccttctgccacc	3	15	7	16	1	4	0	0	0	4	0	5	1	4	1	4	2	1	0	4	2	1	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:57857788C>G	uc001snx.2	+	3	185	c.107C>G	c.(106-108)TCT>TGT	p.S36C	GLI1_uc009zpp.2_RNA|GLI1_uc009zpq.2_Intron|GLI1_uc009zpr.1_Intron	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	36					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CTAGGACTGTCTGGCCCGCCC	0.552													42	204					0	0	0	0	G	57857788	G	G	57857788	3	3	214	1	0	0	0	0	1	0	0	0	6474	913	32	2	113	2	GLI1	12	57857788	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	372802	57857788	75994107	392	39282											
OS9	10956	broad.mit.edu	37	chr12	58112070	58112070	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggatgaggatgaggatgaaGatgaggatgaacggcagtta	15	7	17	2	1	0	6	0	5	0	1	0	10	0	10	0	5	1	2	0	5	3	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:58112070G>C	uc001spj.2	+	11	1335	c.1276G>C	c.(1276-1278)GAT>CAT	p.D426H	OS9_uc010srx.1_Missense_Mutation_p.D220H|OS9_uc001spk.2_Missense_Mutation_p.D426H|OS9_uc001spl.2_Missense_Mutation_p.D426H|OS9_uc001spm.2_Missense_Mutation_p.D426H|OS9_uc001spn.2_Missense_Mutation_p.D427H|OS9_uc010sry.1_Missense_Mutation_p.D394H|OS9_uc010srz.1_Missense_Mutation_p.D367H	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	426	Asp/Glu-rich (acidic).				ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			tgaggatgaagatgaggatga	0.408													6	74					0	0	0	0	C	58112070	C	C	58112070	3	2	214	1	0	0	0	0	1	0	0	0	11326	942	33	2	1318	2	OS9	12	58112070	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	254282	58112070	75739825	393	39283											
BEST3	144453	broad.mit.edu	37	chr12	70049339	70049339	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttccttctgggaagcaggatTtcttccaggtgggtgaggcc	6	12	14	9	0	2	1	0	1	2	0	4	3	4	3	3	5	1	1	3	5	1	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:70049339T>A	uc001svg.2	-	10	1582	c.1355A>T	c.(1354-1356)AAA>ATA	p.K452I	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.K239I|BEST3_uc010stm.1_Missense_Mutation_p.K346I	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	452	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GAAGCAGGATTTCTTCCAGGT	0.592													5	108					0	0	0	0	A	70049339	A	A	70049339	3	1	214	1	0	0	0	0	1	0	0	0	1408	1841	64	5	655	5	BEST3	12	70049339	Missense_Mutation	SNP	T	TCGA-CV-6961-01A-21D-1912-08	11937269	70049339	63802556	394	39284											
BEST3	144453	broad.mit.edu	37	chr12	70049452	70049452	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagctgtcacttgtctgcctCctgtagcttcttcttctggg	3	16	10	12	0	5	0	1	0	4	0	6	1	6	0	2	1	3	3	2	1	1	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:70049452C>G	uc001svg.2	-	10	1469	c.1242G>C	c.(1240-1242)AGG>AGC	p.R414S	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.R201S|BEST3_uc010stm.1_Missense_Mutation_p.R308S	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	414	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TTGTCTGCCTCCTGTAGCTTC	0.562													25	114					0	0	0	0	G	70049452	G	G	70049452	3	3	214	1	0	0	0	0	1	0	0	0	1408	854	30	2	768	2	BEST3	12	70049452	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	113	70049452	63802443	395	39285											
LRRIQ1	84125	broad.mit.edu	37	chr12	85450679	85450679	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtatctaaagaagtcaactCtcttaaatctgagattagaa	16	12	7	6	0	4	3	1	1	3	3	5	4	4	3	0	1	1	1	0	1	9	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:85450679C>G	uc001tac.2	+	8	2219	c.2108C>G	c.(2107-2109)TCT>TGT	p.S703C	LRRIQ1_uc001tab.1_Missense_Mutation_p.S703C|LRRIQ1_uc001taa.1_Missense_Mutation_p.S678C	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	703										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GAAGTCAACTCTCTTAAATCT	0.373													46	119					0	0	0	0	G	85450679	G	G	85450679	3	3	214	1	0	0	0	0	1	0	0	0	9079	913	32	2	2134	2	LRRIQ1	12	85450679	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	15401227	85450679	48401216	396	39286											
LRRIQ1	84125	broad.mit.edu	37	chr12	85500377	85500377	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttactggaaacccacttcttCaagaaacaaactggaggtaa	16	9	7	9	0	2	1	1	0	1	1	2	3	2	3	1	3	4	1	1	3	6	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:85500377C>T	uc001tac.2	+	15	3472	c.3361C>T	c.(3361-3363)CAA>TAA	p.Q1121*	LRRIQ1_uc001tab.1_Nonsense_Mutation_p.Q1121*	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1121	LRRCT.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CCCACTTCTTCAAGAAACAAA	0.333													11	61					0	0	0	0	T	85500377	T	T	85500377	4	4	214	1	0	0	0	0	0	1	0	0	9079	827	29	2	3415	2	LRRIQ1	12	85500377	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	49698	85500377	48351518	397	39287											
EPYC	1833	broad.mit.edu	37	chr12	91358091	91358091	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtatcttcgtgcatttccaGaatgttgttattctaaaaaa	12	16	6	7	2	2	1	0	0	2	1	4	1	3	1	1	0	1	4	1	0	6	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:91358091G>A	uc001tbk.2	-	7	904	c.811C>T	c.(811-813)CTG>TTG	p.L271L		NM_004950	NP_004941	Q99645	EPYC_HUMAN	dermatan sulfate proteoglycan 3 precursor	271	LRR 5.				female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			skin(1)	1						TGCATTTCCAGAATGTTGTTA	0.338													5	22					0	0	0	0	A	91358091	A	A	91358091	2	1	214	1	0	0	0	0	0	0	0	1	5225	933	33	2		2	EPYC	12	91358091	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5857714	91358091	42493804	398	39288											
PLEKHG7	440107	broad.mit.edu	37	chr12	93163911	93163911	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaatttcttgctttaccaaGagtcaggaaaccaagaaaat	16	10	7	8	0	2	2	1	0	1	2	2	3	2	3	2	1	3	2	2	1	7	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:93163911G>C	uc001tcj.2	+	12	1310	c.1080G>C	c.(1078-1080)AAG>AAC	p.K360N		NM_001004330	NP_001004330	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G	360					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1						GCTTTACCAAGAGTCAGGAAA	0.333													14	37					0	0	0	0	C	93163911	C	C	93163911	3	2	214	1	0	0	0	0	1	0	0	0	12130	933	33	2	1122	2	PLEKHG7	12	93163911	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1805820	93163911	40687984	399	39289											
NUP37	79023	broad.mit.edu	37	chr12	102471251	102471251	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccaaaagatcataaaaccGgattgttccattcttctctg	12	12	7	10	1	3	1	1	0	2	1	5	2	4	2	3	2	1	1	3	2	4	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:102471251G>A	uc001tjc.2	-	6	636	c.571C>T	c.(571-573)CGG>TGG	p.R191W	NUP37_uc009zub.1_Missense_Mutation_p.R191W	NM_024057	NP_076962	Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	191	WD 3.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			ovary(1)	1						TCATAAAACCGGATTGTTCCA	0.368													20	62					0	0	0	0	A	102471251	A	A	102471251	3	1	214	1	0	0	0	0	1	0	0	0	10818	1115	39	1	425	1	NUP37	12	102471251	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9307340	102471251	31380644	400	39290											
STAB2	55576	broad.mit.edu	37	chr12	104129353	104129353	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgaaatgtggagctggcaggGacatcgtgagtatcatcatg	11	10	14	6	1	2	2	2	2	0	0	3	4	2	4	0	3	1	3	0	3	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:104129353G>A	uc001tjw.2	+	52	5731	c.5545G>A	c.(5545-5547)GAC>AAC	p.D1849N	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1849	Extracellular (Potential).|FAS1 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AGCTGGCAGGGACATCGTGAG	0.507													3	10					0	0	0	0	A	104129353	A	A	104129353	3	1	214	1	0	0	0	0	1	0	0	0	15304	1174	41	2	5751	2	STAB2	12	104129353	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1658102	104129353	29722542	401	39291											
SVOP	55530	broad.mit.edu	37	chr12	109306418	109306418	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactcctgcagtcctcggcCtttggtctcaatgggcaaaa	8	10	11	12	1	1	0	1	0	1	0	5	1	3	1	3	4	1	2	3	4	3	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:109306418C>A	uc010sxh.1	-	15	1712	c.1540G>T	c.(1540-1542)GGC>TGC	p.G514C		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	514	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						AGTCCTCGGCCTTTGGTCTCA	0.607													44	79					6.4771e-29	7.19169e-29	1	0	A	109306418	A	A	109306418	3	1	214	1	0	0	0	0	1	0	0	0	15489	681	24	4	110	4	SVOP	12	109306418	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5177065	109306418	24545477	402	39292											
CIT	11113	broad.mit.edu	37	chr12	120241085	120241085	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcttcacccgagaagcctGaggggctcagctggcacgga	8	7	14	12	2	3	2	2	1	1	1	3	4	3	3	2	4	2	4	2	4	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:120241085G>A	uc001txi.1	-	10	1273	c.1220C>T	c.(1219-1221)TCA>TTA	p.S407L	CIT_uc001txh.1_5'UTR|CIT_uc001txj.1_Missense_Mutation_p.S407L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	407	AGC-kinase C-terminal.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CGAGAAGCCTGAGGGGCTCAG	0.493													34	85					0	0	0	0	A	120241085	A	A	120241085	3	1	214	1	0	0	0	0	1	0	0	0	3453	1294	45	2	5015	2	CIT	12	120241085	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	10934667	120241085	13610810	403	39293											
RPLP0	6175	broad.mit.edu	37	chr12	120635242	120635242	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtagccaatctgcagacaGacactggcaacattgcggac	12	6	12	11	1	1	2	0	0	1	2	1	3	1	3	1	3	4	3	1	3	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:120635242G>C	uc001txp.2	-	7	912	c.675C>G	c.(673-675)GTC>GTG	p.V225V	GCN1L1_uc001txo.2_5'Flank|RPLP0_uc001txq.2_Silent_p.V225V|RPLP0_uc001txr.2_Silent_p.V163V	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	225					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCTGCAGACAGACACTGGCAA	0.488													16	31					0	0	0	0	C	120635242	C	C	120635242	2	2	214	1	0	0	0	0	0	0	0	1	13669	929	33	2		2	RPLP0	12	120635242	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	394157	120635242	13216653	404	39294											
VPS33A	65082	broad.mit.edu	37	chr12	122750886	122750886	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcacttgtccaggaactcgcGcagctcgcgacgcaccgcct	7	6	11	17	6	0	0	0	0	0	0	3	2	1	1	3	1	2	4	3	1	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:122750886G>T	uc001ucd.2	-	1	183	c.70C>A	c.(70-72)CGC>AGC	p.R24S	VPS33A_uc001ucc.2_RNA|VPS33A_uc001uce.2_Missense_Mutation_p.R24S	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	24					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		AGGAACTCGCGCAGCTCGCGA	0.667													10	41					4.68919e-08	4.97434e-08	1	0	T	122750886	T	T	122750886	3	4	214	1	0	0	0	0	1	0	0	0	17269	1087	38	3	1772	3	VPS33A	12	122750886	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2115644	122750886	11101009	405	39295											
ZCCHC8	55596	broad.mit.edu	37	chr12	122958596	122958596	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagctgcccagatccgcctCtgctgttcttcaagttcttc	6	13	8	14	1	4	2	1	0	3	2	6	2	5	2	3	0	3	4	3	0	1	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:122958596C>T	uc001ucn.2	-	14	1703	c.1572G>A	c.(1570-1572)CAG>CAA	p.Q524Q	ZCCHC8_uc001ucl.2_Silent_p.Q135Q|ZCCHC8_uc001ucm.2_Silent_p.Q286Q|ZCCHC8_uc009zxp.2_Silent_p.Q286Q|ZCCHC8_uc009zxq.2_Silent_p.Q286Q	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	524	Potential.					catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		AGATCCGCCTCTGCTGTTCTT	0.572													51	107					0	0	0	0	T	122958596	T	T	122958596	2	4	214	1	0	0	0	0	0	0	0	1	17661	912	32	2		2	ZCCHC8	12	122958596	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	207710	122958596	10893299	406	39296											
DNAH10	196385	broad.mit.edu	37	chr12	124298073	124298073	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattgcatcagacttcagctCaggcatctggcaaacacagt	12	9	8	12	0	4	1	3	0	1	1	4	1	4	1	0	2	3	4	0	2	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:124298073C>G	uc001uft.3	+	19	3178	c.3153C>G	c.(3151-3153)CTC>CTG	p.L1051L	DNAH10_uc010tav.1_Silent_p.L593L|DNAH10_uc010taw.1_Silent_p.L536L	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1051	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GACTTCAGCTCAGGCATCTGG	0.438													11	36					0	0	0	0	G	124298073	G	G	124298073	2	3	214	1	0	0	0	0	0	0	0	1	4620	813	29	2		2	DNAH10	12	124298073	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1339477	124298073	9553822	407	39297											
POLE	5426	broad.mit.edu	37	chr12	133248806	133248806	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccctgatggttacctcttCaaagttggtgacttgctcca	7	14	8	12	0	2	2	1	2	1	0	4	2	4	2	3	2	2	3	3	2	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:133248806C>T	uc001uks.1	-	16	1833	c.1789G>A	c.(1789-1791)GAA>AAA	p.E597K	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.E570K	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	597					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GTTACCTCTTCAAAGTTGGTG	0.557								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					12	64					0	0	0	0	T	133248806	T	T	133248806	3	4	214	1	0	0	0	0	1	0	0	0	12251	835	29	2	5207	2	POLE	12	133248806	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	8950733	133248806	603089	408	39298											
ZNF10	7556	broad.mit.edu	37	chr12	133732691	133732691	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttactaggcatcagcttattCatactggagaaaaaccctat	14	12	6	9	0	2	1	2	0	0	1	2	2	2	1	1	2	4	2	1	2	7	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr12:133732691C>T	uc009zzb.2	+	5	1306	c.859C>T	c.(859-861)CAT>TAT	p.H287Y	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.H287Y	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	287	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TCAGCTTATTCATACTGGAGA	0.418													16	39					0	0	0	0	T	133732691	T	T	133732691	3	4	214	1	0	0	0	0	1	0	0	0	17779	826	29	2	873	2	ZNF10	12	133732691	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	483885	133732691	119204	409	39299											
RNF17	56163	broad.mit.edu	37	chr13	25348972	25348972	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgctacagctgtaaatactAgacaacgctactacccaatg	14	10	6	11	1	0	1	0	0	0	1	0	1	0	1	1	0	7	4	1	0	9	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr13:25348972A>C	uc001upr.2	+	3	288	c.247A>C	c.(247-249)AGA>CGA	p.R83R	RNF17_uc010tdd.1_Intron|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Silent_p.R83R|RNF17_uc001ups.2_Silent_p.R22R|RNF17_uc001upq.1_Silent_p.R83R	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	83					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TGTAAATACTAGACAACGCTA	0.348													16	27					0	0	0	0	C	25348972	C	C	25348972	2	2	214	1	0	0	0	0	0	0	0	1	13526	412	15	5		5	RNF17	13	25348972	Silent	SNP	A	TCGA-CV-6961-01A-21D-1912-08		25348972	89820906	410	39300											
USPL1	10208	broad.mit.edu	37	chr13	31232715	31232715	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccaccagcaggccctccatCgtctaatggcacagctgccc	8	6	9	18	1	1	0	0	0	1	0	3	0	2	0	5	2	3	3	5	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr13:31232715C>T	uc001utc.2	+	9	2933	c.2501C>T	c.(2500-2502)TCG>TTG	p.S834L	USPL1_uc001utd.2_Missense_Mutation_p.S505L|USPL1_uc001ute.1_Missense_Mutation_p.S505L	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	834					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		GGCCCTCCATCGTCTAATGGC	0.507													17	70					0	0	0	0	T	31232715	T	T	31232715	3	4	214	1	0	0	0	0	1	0	0	0	17160	893	31	1	2531	1	USPL1	13	31232715	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5883743	31232715	83937163	411	39301											
STARD13	90627	broad.mit.edu	37	chr13	33703293	33703293	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagtttgcagttcaggcaaGacatctttggaccagtcatc	10	12	10	9	0	3	2	2	1	1	1	4	3	3	3	1	2	1	4	1	2	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr13:33703293G>T	uc001uuw.2	-	5	1647	c.1521C>A	c.(1519-1521)GTC>GTA	p.V507V	STARD13_uc001uuu.2_Silent_p.V499V|STARD13_uc001uuv.2_Silent_p.V389V|STARD13_uc001uux.2_Silent_p.V472V|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Silent_p.V492V	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	507					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GTTCAGGCAAGACATCTTTGG	0.448													23	90					6.21321e-17	6.83105e-17	1	0	T	33703293	T	T	33703293	2	4	214	1	0	0	0	0	0	0	0	1	15322	929	33	2		2	STARD13	13	33703293	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2470578	33703293	81466585	412	39302											
HTR2A	3356	broad.mit.edu	37	chr13	47466711	47466711	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcacaaagcttgctcggcaGaggccaccggtaccctatga	10	7	11	13	2	0	2	0	1	0	1	1	2	0	2	3	3	4	5	3	3	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr13:47466711G>A	uc001vbq.2	-	2	561	c.427C>T	c.(427-429)CTG>TTG	p.L143L	HTR2A_uc001vbr.2_Silent_p.L43L|HTR2A_uc010acr.2_Silent_p.L143L	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	143	Extracellular (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TTGCTCGGCAGAGGCCACCGG	0.572													20	84					0	0	0	0	A	47466711	A	A	47466711	2	1	214	1	0	0	0	0	0	0	0	1	7480	933	33	2		2	HTR2A	13	47466711	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	13763418	47466711	67703167	413	39303											
MLNR	2862	broad.mit.edu	37	chr13	49796350	49796350	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcctctacaacctcatttCaaagaagtacagagcggcgg	14	8	8	11	2	3	2	2	0	1	2	4	2	4	2	2	2	4	1	2	2	6	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr13:49796350C>T	uc010tgj.1	+	2	1076	c.1076C>T	c.(1075-1077)TCA>TTA	p.S359L		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	359	Cytoplasmic (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		AACCTCATTTCAAAGAAGTAC	0.512													37	105					0	0	0	0	T	49796350	T	T	49796350	3	4	214	1	0	0	0	0	1	0	0	0	9685	838	29	2	1082	2	MLNR	13	49796350	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2329639	49796350	65373528	414	39304											
PCDH17	27253	broad.mit.edu	37	chr13	58208612	58208612	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgacccgtccagcggcgaGatccgcacgctgcacccttt	7	7	10	17	6	0	1	0	0	0	1	3	3	2	1	4	1	2	3	4	1	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr13:58208612G>T	uc001vhq.1	+	1	2824	c.1932G>T	c.(1930-1932)GAG>GAT	p.E644D	PCDH17_uc010aec.1_Missense_Mutation_p.E644D	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	644	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCAGCGGCGAGATCCGCACGC	0.657													43	122					2.13384e-23	2.36257e-23	1	0	T	58208612	T	T	58208612	3	4	214	1	0	0	0	0	1	0	0	0	11566	933	33	2	1934	2	PCDH17	13	58208612	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	8412262	58208612	56961266	415	39305											
ZIC5	85416	broad.mit.edu	37	chr13	100622424	100622424	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgaggttctcggagcgcgcGaagaccttgccgcagccggg	6	7	16	12	6	1	2	0	1	1	1	2	4	1	3	3	3	3	2	3	3	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr13:100622424G>A	uc001vom.1	-	1	1755	c.1506C>T	c.(1504-1506)TTC>TTT	p.F502F		NM_033132	NP_149123	Q96T25	ZIC5_HUMAN	zinc finger protein of the cerebellum 5	502	C2H2-type 2.				cell differentiation	nucleus	DNA binding|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CGGAGCGCGCGAAGACCTTGC	0.502													22	95					0	0	0	0	A	100622424	A	A	100622424	2	1	214	1	0	0	0	0	0	0	0	1	17749	1049	37	1		1	ZIC5	13	100622424	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	42413812	100622424	14547454	416	39306											
FLJ10357	55701	broad.mit.edu	37	chr14	21556189	21556189	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caagaaacagccccagcctgCaacccccccaccctgggagc	11	2	8	20	0	0	1	0	0	0	1	0	2	0	2	7	1	6	1	7	1	3	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:21556189C>A	uc001vzp.2	+	22	4479	c.4450C>A	c.(4450-4452)CAA>AAA	p.Q1484K	FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_Missense_Mutation_p.Q722K	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	1484					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		CCCCAGCCTGCAACCCCCCCA	0.577													19	79					1.45105e-14	1.57548e-14	1	0	A	21556189	A	A	21556189	3	1	214	1	0	0	0	0	1	0	0	0	5958	711	25	4	4536	4	FLJ10357	14	21556189	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08		21556189	85793351	417	39307											
SUPT16H	11198	broad.mit.edu	37	chr14	21827748	21827748	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcacatccgtgtgccgcttCttcccaaacatgatggcatt	8	12	8	13	2	1	1	0	1	1	0	3	1	3	1	3	1	3	3	3	1	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:21827748C>G	uc001wao.2	-	19	2535	c.2196G>C	c.(2194-2196)AAG>AAC	p.K732N	SUPT16H_uc001wan.2_5'Flank	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	732					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TGTGCCGCTTCTTCCCAAACA	0.463													18	49					0	0	0	0	G	21827748	G	G	21827748	3	3	214	1	0	0	0	0	1	0	0	0	15462	912	32	2	979	2	SUPT16H	14	21827748	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	271559	21827748	85521792	418	39308											
CDH24	64403	broad.mit.edu	37	chr14	23523752	23523752	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggttgtcgttgacatcgctGagcgtgacagtcaccgtagt	7	11	14	9	4	1	3	1	3	0	0	3	3	1	3	1	1	1	4	1	1	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:23523752G>C	uc001wil.2	-	5	1007	c.747C>G	c.(745-747)CTC>CTG	p.L249L	CDH24_uc010akf.2_Silent_p.L249L|CDH24_uc001win.3_Silent_p.L249L	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	249	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		TGACATCGCTGAGCGTGACAG	0.607											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	27					0	0	0	0	C	23523752	C	C	23523752	2	2	214	1	0	0	0	0	0	0	0	1	3124	1277	45	2		2	CDH24	14	23523752	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1696004	23523752	83825788	419	39309											
ACIN1	22985	broad.mit.edu	37	chr14	23548138	23548138	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtcctctcctttggctcaCagacctgcagttgtggcact	7	12	9	13	0	2	1	1	0	1	1	4	1	3	1	3	2	1	4	3	2	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:23548138C>G	uc001wit.3	-	7	2400	c.2072G>C	c.(2071-2073)TGT>TCT	p.C691S	ACIN1_uc001wis.3_Missense_Mutation_p.C373S|ACIN1_uc010akg.2_Missense_Mutation_p.C691S	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	691					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CTTTGGCTCACAGACCTGCAG	0.542													9	39					0	0	0	0	G	23548138	G	G	23548138	3	3	214	1	0	0	0	0	1	0	0	0	142	478	17	4	2152	4	ACIN1	14	23548138	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	24386	23548138	83801402	420	39310											
ACIN1	22985	broad.mit.edu	37	chr14	23549752	23549752	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggatcttgttttgggtctCtcatccatcatctcctctgg	4	17	9	11	0	6	0	2	0	4	0	9	1	7	1	2	3	0	1	2	3	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:23549752C>G	uc001wit.3	-	6	1294	c.966G>C	c.(964-966)GAG>GAC	p.E322D	ACIN1_uc001wis.3_Missense_Mutation_p.E4D|ACIN1_uc010akg.2_Missense_Mutation_p.E322D|ACIN1_uc010tnj.1_Missense_Mutation_p.E282D	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	322	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TTTTGGGTCTCTCATCCATCA	0.463													30	83					0	0	0	0	G	23549752	G	G	23549752	3	3	214	1	0	0	0	0	1	0	0	0	142	912	32	2	3262	2	ACIN1	14	23549752	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1614	23549752	83799788	421	39311											
NYNRIN	57523	broad.mit.edu	37	chr14	24884017	24884017	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaggaggacgaccttgactCttcgctggcgtcagtgttca	7	11	13	10	3	3	2	2	2	1	0	4	5	3	4	1	3	0	2	1	3	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:24884017C>G	uc001wpf.3	+	9	3380	c.3062C>G	c.(3061-3063)TCT>TGT	p.S1021C		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1021					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GACCTTGACTCTTCGCTGGCG	0.607													22	35					0	0	0	0	G	24884017	G	G	24884017	3	3	214	1	0	0	0	0	1	0	0	0	10850	913	32	2	3092	2	NYNRIN	14	24884017	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1334265	24884017	82465523	422	39312											
MIA2	117153	broad.mit.edu	37	chr14	39716595	39716595	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattaaataatggtgagcctCaaacagaacatcagcaagaa	20	7	7	7	0	2	3	2	1	0	2	2	3	2	3	1	1	4	1	1	1	8	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:39716595C>T	uc001wux.2	+	4	1011	c.817C>T	c.(817-819)CAA>TAA	p.Q273*	MIA2_uc010amy.1_Nonsense_Mutation_p.Q204*	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	273						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		TGGTGAGCCTCAAACAGAACA	0.393													9	36					0	0	0	0	T	39716595	T	T	39716595	4	4	214	1	0	0	0	0	0	1	0	0	9617	827	29	2	831	2	MIA2	14	39716595	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	14832578	39716595	67632945	423	39313											
WDHD1	11169	broad.mit.edu	37	chr14	55474026	55474026	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttggctgccaagcaagtCtgcagattgattttgcattt	8	17	9	7	0	1	2	0	1	1	1	1	2	1	2	1	1	4	4	1	1	2	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:55474026C>T	uc001xbm.1	-	7	650	c.572G>A	c.(571-573)AGA>AAA	p.R191K	WDHD1_uc001xbn.1_Missense_Mutation_p.R68K	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	191	WD 5.					cytoplasm|nucleoplasm	DNA binding			skin(1)	1						CCAAGCAAGTCTGCAGATTGA	0.254													6	26					0	0	0	0	T	55474026	T	T	55474026	3	4	214	1	0	0	0	0	1	0	0	0	17339	913	32	2	2897	2	WDHD1	14	55474026	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	15757431	55474026	51875514	424	39314											
ESR2	2100	broad.mit.edu	37	chr14	64746790	64746790	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taatcgctgcagacagcgcaGaagtgagcatccctctttga	11	9	10	11	2	1	4	0	2	1	2	3	4	2	4	1	0	3	4	1	0	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:64746790G>A	uc001xha.1	-	3	912	c.444C>T	c.(442-444)TTC>TTT	p.F148F	ESR2_uc001xgu.2_Silent_p.F148F|ESR2_uc001xgv.2_Silent_p.F148F|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Silent_p.F148F|ESR2_uc001xgy.1_Silent_p.F148F|ESR2_uc001xgz.1_Silent_p.F148F|ESR2_uc010aqb.1_Intron|ESR2_uc010aqc.1_Silent_p.F148F	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	148	Modulating.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	AGACAGCGCAGAAGTGAGCAT	0.478													39	190					0	0	0	0	A	64746790	A	A	64746790	2	1	214	1	0	0	0	0	0	0	0	1	5281	933	33	2		2	ESR2	14	64746790	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9272764	64746790	42602750	425	39315											
GALNTL1	57452	broad.mit.edu	37	chr14	69805378	69805378	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcctgcagagctctccttCagggtgtggatgtgtggtgg	4	14	15	8	0	2	1	1	0	1	1	4	2	3	2	2	4	2	2	2	4	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:69805378C>G	uc010aqu.1	+	10	1071	c.978C>G	c.(976-978)TTC>TTG	p.F326L	GALNTL1_uc001xla.1_Missense_Mutation_p.F326L|GALNTL1_uc001xlb.1_Missense_Mutation_p.F326L	NM_020692	NP_065743	Q8N428	GLTL1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	326	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)		AGCTCTCCTTCAGGGTGTGGA	0.592													11	92					0	0	0	0	G	69805378	G	G	69805378	3	3	214	1	0	0	0	0	1	0	0	0	6256	825	29	2	1016	2	GALNTL1	14	69805378	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5058588	69805378	37544162	426	39316											
NRXN3	9369	broad.mit.edu	37	chr14	79432618	79432618	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaccaagagcagctacctGagccttgccactcttcaggc	11	7	9	14	0	2	3	1	1	1	2	2	3	2	3	4	1	5	2	4	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:79432618G>A	uc001xun.2	+	9	2018	c.1527G>A	c.(1525-1527)CTG>CTA	p.L509L	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.L634L	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	882	Extracellular (Potential).|Laminin G-like 5.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCAGCTACCTGAGCCTTGCCA	0.483													17	81					0	0	0	0	A	79432618	A	A	79432618	2	1	214	1	0	0	0	0	0	0	0	1	10721	1277	45	2		2	NRXN3	14	79432618	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9627240	79432618	27916922	427	39317											
TRIP11	9321	broad.mit.edu	37	chr14	92469778	92469778	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacacctgttctttctctttCaatagctgttcaaaagcaag	11	14	5	11	0	4	0	2	0	2	0	5	0	4	0	1	0	2	4	1	0	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92469778C>T	uc001xzy.2	-	11	5330	c.4542G>A	c.(4540-4542)TTG>TTA	p.L1514L	TRIP11_uc010auf.1_Silent_p.L1250L	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1514	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CTTTCTCTTTCAATAGCTGTT	0.378			T	PDGFRB	AML								6	52					0	0	0	0	T	92469778	T	T	92469778	2	4	214	1	0	0	0	0	0	0	0	1	16622	825	29	2		2	TRIP11	14	92469778	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	13037160	92469778	14879762	428	39318			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92469811	92469811	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagcaagagccttctccttCattgagtggcactcaaactc	12	10	7	12	0	3	2	2	1	1	1	5	2	3	2	2	1	3	2	2	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92469811C>T	uc001xzy.2	-	11	5297	c.4509G>A	c.(4507-4509)ATG>ATA	p.M1503I	TRIP11_uc010auf.1_Missense_Mutation_p.M1239I	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1503	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CCTTCTCCTTCATTGAGTGGC	0.413			T	PDGFRB	AML								15	64					0	0	0	0	T	92469811	T	T	92469811	3	4	214	1	0	0	0	0	1	0	0	0	16622	826	29	2	1474	2	TRIP11	14	92469811	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	33	92469811	14879729	429	39319			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92469841	92469841	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcaaactctttttctcgCagcatcatagaaaacttcat	13	13	3	12	1	5	1	3	0	2	1	6	1	5	1	0	0	3	2	0	0	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92469841C>T	uc001xzy.2	-	11	5267	c.4479G>A	c.(4477-4479)CTG>CTA	p.L1493L	TRIP11_uc010auf.1_Silent_p.L1229L	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1493	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CTTTTTCTCGCAGCATCATAG	0.378			T	PDGFRB	AML								20	92					0	0	0	0	T	92469841	T	T	92469841	2	4	214	1	0	0	0	0	0	0	0	1	16622	697	25	4		4	TRIP11	14	92469841	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	30	92469841	14879699	430	39320			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92470322	92470322	+	Missense_Mutation	SNP	C	T	T																															cactcaatacttcagacttaCttgctctaagacactctgca																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92470322C>T	uc001xzy.2	-	11	4786	c.3998G>A	c.(3997-3999)AGT>AAT	p.S1333N	TRIP11_uc010auf.1_Missense_Mutation_p.S1069N	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1333	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTCAGACTTACTTGCTCTAAG	0.383			T	PDGFRB	AML								12	59					0	0	0	0	T	92470322	T	T	92470322	3	4	214	1	0	0	0	0	1	0	0	0	16622	565	20	4	1985	4	TRIP11	14	92470322	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	481	92470322	14879218	431	39321	76	2	3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92470328	92470328	+	Missense_Mutation	SNP	C	G	G																															atacttcagacttacttgctCtaagacactctgcagactgg																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92470328C>G	uc001xzy.2	-	11	4780	c.3992G>C	c.(3991-3993)AGA>ACA	p.R1331T	TRIP11_uc010auf.1_Missense_Mutation_p.R1067T	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1331	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CTTACTTGCTCTAAGACACTC	0.383			T	PDGFRB	AML								9	57					0	0	0	0	G	92470328	G	G	92470328	3	3	214	1	0	0	0	0	1	0	0	0	16622	913	32	2	1991	2	TRIP11	14	92470328	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	6	92470328	14879212	432	39322	76	2	3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92470587	92470587	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttgaagttggtgaagctCttcctgaagctgggctgact	7	13	13	8	0	1	4	0	4	1	0	2	4	2	4	1	2	3	5	1	2	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92470587C>G	uc001xzy.2	-	11	4521	c.3733G>C	c.(3733-3735)GAG>CAG	p.E1245Q	TRIP11_uc010auf.1_Missense_Mutation_p.E981Q	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1245	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TGGTGAAGCTCTTCCTGAAGC	0.408			T	PDGFRB	AML								8	39					0	0	0	0	G	92470587	G	G	92470587	3	3	214	1	0	0	0	0	1	0	0	0	16622	922	32	2	2250	2	TRIP11	14	92470587	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	259	92470587	14878953	433	39323			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92470704	92470704	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcacgttcctgtagaagctCctcaaattgattactattaa	12	14	6	9	1	2	2	2	1	0	1	4	2	4	2	2	0	2	3	2	0	6	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92470704C>T	uc001xzy.2	-	11	4404	c.3616G>A	c.(3616-3618)GAG>AAG	p.E1206K	TRIP11_uc010auf.1_Missense_Mutation_p.E942K	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1206	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TGTAGAAGCTCCTCAAATTGA	0.398			T	PDGFRB	AML								16	64					0	0	0	0	T	92470704	T	T	92470704	3	4	214	1	0	0	0	0	1	0	0	0	16622	864	30	2	2367	2	TRIP11	14	92470704	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	117	92470704	14878836	434	39324			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92471001	92471001	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctattttccctagtcttctCattcaaaacagcaaatacct	12	14	3	12	0	3	0	2	0	2	0	5	0	4	0	2	0	3	2	2	0	6	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92471001C>T	uc001xzy.2	-	11	4107	c.3319G>A	c.(3319-3321)GAG>AAG	p.E1107K	TRIP11_uc010auf.1_Missense_Mutation_p.E843K	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1107	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CTAGTCTTCTCATTCAAAACA	0.363			T	PDGFRB	AML								13	35					0	0	0	0	T	92471001	T	T	92471001	3	4	214	1	0	0	0	0	1	0	0	0	16622	835	29	2	2664	2	TRIP11	14	92471001	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	297	92471001	14878539	435	39325			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92471131	92471131	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttgtatctccaaatctttCtgctgaataatctgagttag	10	16	7	8	0	4	2	0	2	4	0	5	2	4	2	1	0	1	4	1	0	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92471131C>T	uc001xzy.2	-	11	3977	c.3189G>A	c.(3187-3189)CAG>CAA	p.Q1063Q	TRIP11_uc010auf.1_Silent_p.Q799Q	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1063	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CCAAATCTTTCTGCTGAATAA	0.343			T	PDGFRB	AML								14	42					0	0	0	0	T	92471131	T	T	92471131	2	4	214	1	0	0	0	0	0	0	0	1	16622	912	32	2		2	TRIP11	14	92471131	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	130	92471131	14878409	436	39326			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92471181	92471181	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatctttggacaactgatCaatctgtttagttaaagata	13	16	6	6	0	4	2	2	1	2	1	4	3	4	3	0	1	1	2	0	1	6	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92471181C>G	uc001xzy.2	-	11	3927	c.3139G>C	c.(3139-3141)GAT>CAT	p.D1047H	TRIP11_uc010auf.1_Missense_Mutation_p.D783H	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1047	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		GACAACTGATCAATCTGTTTA	0.328			T	PDGFRB	AML								9	41					0	0	0	0	G	92471181	G	G	92471181	3	3	214	1	0	0	0	0	1	0	0	0	16622	826	29	2	2844	2	TRIP11	14	92471181	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	50	92471181	14878359	437	39327			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92471470	92471470	+	Missense_Mutation	SNP	C	T	T																															agctgggtgtgtgtggcgttCatttgctcatgctggtatct																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92471470C>T	uc001xzy.2	-	11	3638	c.2850G>A	c.(2848-2850)ATG>ATA	p.M950I	TRIP11_uc010auf.1_Missense_Mutation_p.M686I	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	950	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		GTGTGGCGTTCATTTGCTCAT	0.368			T	PDGFRB	AML								15	113					0	0	0	0	T	92471470	T	T	92471470	3	4	214	1	0	0	0	0	1	0	0	0	16622	826	29	2	3133	2	TRIP11	14	92471470	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	289	92471470	14878070	438	39328	77	2	3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92471478	92471478	+	Missense_Mutation	SNP	C	T	T																															gtgtgtggcgttcatttgctCatgctggtatctaaactcat																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92471478C>T	uc001xzy.2	-	11	3630	c.2842G>A	c.(2842-2844)GAG>AAG	p.E948K	TRIP11_uc010auf.1_Missense_Mutation_p.E684K	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	948	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTCATTTGCTCATGCTGGTAT	0.363			T	PDGFRB	AML								15	106					0	0	0	0	T	92471478	T	T	92471478	3	4	214	1	0	0	0	0	1	0	0	0	16622	835	29	2	3141	2	TRIP11	14	92471478	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	8	92471478	14878062	439	39329	77	2	3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92471517	92471517	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atccatttccttcttttgctCttgtaaagactgaagtagtt	9	18	6	8	0	2	2	0	1	2	1	4	2	4	2	2	0	1	4	2	0	4	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92471517C>G	uc001xzy.2	-	11	3591	c.2803G>C	c.(2803-2805)GAG>CAG	p.E935Q	TRIP11_uc010auf.1_Missense_Mutation_p.E671Q	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	935	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTCTTTTGCTCTTGTAAAGAC	0.368			T	PDGFRB	AML								15	107					0	0	0	0	G	92471517	G	G	92471517	3	3	214	1	0	0	0	0	1	0	0	0	16622	922	32	2	3180	2	TRIP11	14	92471517	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	39	92471517	14878023	440	39330			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92471562	92471562	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttactctggttttgatcttCaattatcttttgatgatgtt	7	22	6	6	0	4	3	1	3	3	0	4	3	4	3	0	1	1	2	0	1	3	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92471562C>T	uc001xzy.2	-	11	3546	c.2758G>A	c.(2758-2760)GAA>AAA	p.E920K	TRIP11_uc010auf.1_Missense_Mutation_p.E656K	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	920	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTTTGATCTTCAATTATCTTT	0.373			T	PDGFRB	AML								24	86					0	0	0	0	T	92471562	T	T	92471562	3	4	214	1	0	0	0	0	1	0	0	0	16622	835	29	2	3225	2	TRIP11	14	92471562	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	45	92471562	14877978	441	39331			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92471643	92471643	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatacctcagatgctagttCagtaacactatcaagggttt	13	12	8	8	0	3	2	3	0	0	2	3	2	3	2	1	1	3	4	1	1	5	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92471643C>T	uc001xzy.2	-	11	3465	c.2677G>A	c.(2677-2679)GAA>AAA	p.E893K	TRIP11_uc010auf.1_Missense_Mutation_p.E629K	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	893	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		GATGCTAGTTCAGTAACACTA	0.403			T	PDGFRB	AML								18	89					0	0	0	0	T	92471643	T	T	92471643	3	4	214	1	0	0	0	0	1	0	0	0	16622	835	29	2	3306	2	TRIP11	14	92471643	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	81	92471643	14877897	442	39332			3	59		15	13	1866	N	C	2.979565e-26
TRIP11	9321	broad.mit.edu	37	chr14	92488028	92488028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atcgtcatggaaagctgaagGatgatgactaatcccataag	15	9	10	7	1	1	3	1	3	0	0	3	5	2	5	1	2	1	1	1	2	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:92488028G>A	uc001xzy.2	-	4	1248	c.460C>T	c.(460-462)CCT>TCT	p.P154S		NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	154	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		AAAGCTGAAGGATGATGACTA	0.433			T	PDGFRB	AML								11	44					0	0	0	0	A	92488028	A	A	92488028	3	1	214	1	0	0	0	0	1	0	0	0	16622	1174	41	2	5551	2	TRIP11	14	92488028	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	16385	92488028	14861512	443	39333											
RIN3	79890	broad.mit.edu	37	chr14	93022127	93022127	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgttggcaaaggagaggaaGaggaagaggaagatggcatg	15	6	18	2	0	0	4	0	0	0	4	0	8	0	7	0	6	0	3	0	6	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:93022127G>C	uc001yap.2	+	2	228	c.76G>C	c.(76-78)GAG>CAG	p.E26Q	RIN3_uc010auk.2_5'UTR	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	26	Poly-Glu.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				AGGAGAGGAAGAGGAAGAGGA	0.517													14	22					0	0	0	0	C	93022127	C	C	93022127	3	2	214	1	0	0	0	0	1	0	0	0	13438	943	33	2	82	2	RIN3	14	93022127	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	534099	93022127	14327413	444	39334											
KIAA1409	57578	broad.mit.edu	37	chr14	94041424	94041424	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtattatcggagttagatatCatggttccacttcaactact	11	15	7	8	1	2	1	2	0	0	1	4	2	3	2	1	2	2	3	1	2	6	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:94041424C>G	uc001ybv.1	+	14	1643	c.1560C>G	c.(1558-1560)ATC>ATG	p.I520M	KIAA1409_uc001ybs.1_Missense_Mutation_p.I520M	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	697						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AGTTAGATATCATGGTTCCAC	0.328													9	20					0	0	0	0	G	94041424	G	G	94041424	3	3	214	1	0	0	0	0	1	0	0	0	8269	816	29	2	1614	2	KIAA1409	14	94041424	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1019297	94041424	13308116	445	39335											
YY1	7528	broad.mit.edu	37	chr14	100743853	100743853	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggccctatgtgtgccccttCgatggttgtaataagaagtt	9	13	11	8	1	0	1	0	0	0	1	1	2	0	1	3	2	1	3	3	2	4	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:100743853C>T	uc001ygy.1	+	5	1641	c.1161C>T	c.(1159-1161)TTC>TTT	p.F387F	uc001ygz.1_5'Flank	NM_003403	NP_003394	P25490	TYY1_HUMAN	YY1 transcription factor	387	C2H2-type 4.|Involved in masking transactivation domain.				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding				0		Melanoma(154;0.152)				TGTGCCCCTTCGATGGTTGTA	0.458													18	50					0	0	0	0	T	100743853	T	T	100743853	2	4	214	1	0	0	0	0	0	0	0	1	17575	883	31	1		1	YY1	14	100743853	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	6702429	100743853	6605687	446	39336											
RCOR1	23186	broad.mit.edu	37	chr14	103174893	103174893	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgatggatcgccatgcccGgaaacaaaaacgggagcggg	12	5	15	9	4	0	1	0	1	0	0	1	4	0	4	2	4	4	0	2	4	3	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:103174893G>A	uc001ymb.2	+	6	743	c.743G>A	c.(742-744)CGG>CAG	p.R248Q		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	248	Interaction with HDAC1.|Potential.				blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						CGCCATGCCCGGAAACAAAAA	0.463													4	144					0	0	0	0	A	103174893	A	A	103174893	3	1	214	1	0	0	0	0	1	0	0	0	13247	1116	39	1	765	1	RCOR1	14	103174893	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2431040	103174893	4174647	447	39337											
PPP1R13B	23368	broad.mit.edu	37	chr14	104245125	104245125	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggtacatttattacatttCtctgagttcgttgctcttgg	7	18	8	8	1	2	1	0	1	2	0	4	1	2	1	0	2	3	4	0	2	3	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:104245125C>G	uc001yof.1	-	4	594	c.311G>C	c.(310-312)AGA>ACA	p.R104T	PPP1R13B_uc001yog.1_5'UTR	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	104					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				TATTACATTTCTCTGAGTTCG	0.308													17	42					0	0	0	0	G	104245125	G	G	104245125	3	3	214	1	0	0	0	0	1	0	0	0	12417	913	32	2	3017	2	PPP1R13B	14	104245125	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1070232	104245125	3104415	448	39338											
BTBD6	90135	broad.mit.edu	37	chr14	105716079	105716079	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcattggcaaaagcctgtgtCaactttctggagacaagttt	11	12	10	8	0	2	1	1	0	1	1	2	2	2	1	1	2	2	3	1	2	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:105716079C>T	uc010tyq.1	+	5	636	c.528C>T	c.(526-528)GTC>GTT	p.V176V	BRF1_uc010tyo.1_Intron|BRF1_uc010typ.1_Intron|BRF1_uc001yql.2_5'Flank|BRF1_uc001yqo.2_5'Flank|BRF1_uc010axg.1_Intron|BRF1_uc001yqp.2_Intron|BRF1_uc001yqn.2_5'Flank|BRF1_uc010axh.1_5'Flank|BRF1_uc010axj.1_5'Flank	NM_033271	NP_150374	Q96KE9	BTBD6_HUMAN	BTB domain protein BDPL	176						cytoplasmic mRNA processing body					0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.0163)|Epithelial(46;0.0391)	Epithelial(152;0.18)		AAGCCTGTGTCAACTTTCTGG	0.567													6	62					0	0	0	0	T	105716079	T	T	105716079	2	4	214	1	0	0	0	0	0	0	0	1	1550	813	29	2		2	BTBD6	14	105716079	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1470954	105716079	1633461	449	39339											
BTBD6	90135	broad.mit.edu	37	chr14	105716585	105716585	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccaccgattccagtcttctgCctaccgcagcaaccagtggc	8	8	8	17	2	2	0	0	0	2	0	3	1	3	0	6	1	4	2	6	1	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr14:105716585C>A	uc010tyq.1	+	5	1142	c.1034C>A	c.(1033-1035)GCC>GAC	p.A345D	BRF1_uc010tyo.1_Intron|BRF1_uc010typ.1_Intron|BRF1_uc001yql.2_5'Flank|BRF1_uc001yqo.2_5'Flank|BRF1_uc010axg.1_Intron|BRF1_uc001yqp.2_Intron|BRF1_uc001yqn.2_5'Flank|BRF1_uc010axh.1_5'Flank|BRF1_uc010axj.1_5'Flank	NM_033271	NP_150374	Q96KE9	BTBD6_HUMAN	BTB domain protein BDPL	345						cytoplasmic mRNA processing body					0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.0163)|Epithelial(46;0.0391)	Epithelial(152;0.18)		CAGTCTTCTGCCTACCGCAGC	0.622													18	57					3.52763e-06	3.68243e-06	1	0	A	105716585	A	A	105716585	3	1	214	1	0	0	0	0	1	0	0	0	1550	739	26	4	1048	4	BTBD6	14	105716585	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	506	105716585	1632955	450	39340											
TUBGCP5	114791	broad.mit.edu	37	chr15	22850972	22850972	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattgtctcagctcaaggttCtgcacaaagtgtttagtact	10	14	9	8	0	3	0	2	0	2	0	4	1	3	0	0	1	3	5	0	1	4	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:22850972C>T	uc001yur.3	+	11	1364	c.1234C>T	c.(1234-1236)CTG>TTG	p.L412L	TUBGCP5_uc001yuq.2_Silent_p.L412L|TUBGCP5_uc010axz.1_5'UTR	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	412					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		GCTCAAGGTTCTGCACAAAGT	0.448													21	43					0	0	0	0	T	22850972	T	T	22850972	2	4	214	1	0	0	0	0	0	0	0	1	16837	912	32	2		2	TUBGCP5	15	22850972	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08		22850972	79680420	451	39341											
CYFIP1	23191	broad.mit.edu	37	chr15	22935917	22935917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcagtaacatctataagttgGatgccaagaaaagaataaac	19	9	7	6	0	2	2	1	0	1	2	2	3	2	3	1	1	3	2	1	1	9	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:22935917G>A	uc001yus.2	+	9	957	c.853G>A	c.(853-855)GAT>AAT	p.D285N	CYFIP1_uc001yut.2_Missense_Mutation_p.D285N|CYFIP1_uc010aya.1_Missense_Mutation_p.D313N	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	285					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CTATAAGTTGGATGCCAAGAA	0.368													5	26					0	0	0	0	A	22935917	A	A	22935917	3	1	214	1	0	0	0	0	1	0	0	0	4154	1174	41	2	883	2	CYFIP1	15	22935917	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	84945	22935917	79595475	452	39342											
HERC2	8924	broad.mit.edu	37	chr15	28463722	28463722	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctctgcatgatctcagcatGaactccagcagacagacaaa	14	7	8	12	0	2	4	1	2	2	2	4	4	3	4	1	0	4	4	1	0	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:28463722G>A	uc001zbj.2	-	38	6047	c.5941C>T	c.(5941-5943)CAT>TAT	p.H1981Y		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1981					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATCTCAGCATGAACTCCAGCA	0.458													37	71					0	0	0	0	A	28463722	A	A	28463722	3	1	214	1	0	0	0	0	1	0	0	0	7097	1290	45	2	8787	2	HERC2	15	28463722	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5527805	28463722	74067670	453	39343											
TRPM1	4308	broad.mit.edu	37	chr15	31338418	31338418	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctacttacttccattcccaGaagtttaagagctttaggct	10	15	6	10	0	1	2	0	0	1	2	3	2	3	2	2	1	3	3	2	1	5	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:31338418G>C	uc001zfm.2	-	15	1845	c.1717C>G	c.(1717-1719)CTG>GTG	p.L573V	TRPM1_uc010azy.2_Missense_Mutation_p.L480V|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	573	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TCCATTCCCAGAAGTTTAAGA	0.313													11	25					0	0	0	0	C	31338418	C	C	31338418	3	2	214	1	0	0	0	0	1	0	0	0	16652	933	33	2	3146	2	TRPM1	15	31338418	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2874696	31338418	71192974	454	39344											
C15orf57	90416	broad.mit.edu	37	chr15	40849428	40849428	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgattacctctcatcagaatCaagtccatccacaaagaact	15	9	4	13	1	3	2	3	0	1	2	6	3	5	2	3	0	2	0	3	0	5	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:40849428C>G	uc001zmc.1	-	3	478	c.388G>C	c.(388-390)GAT>CAT	p.D130H	uc001zlx.1_RNA|C15orf57_uc001zly.2_Missense_Mutation_p.D128H|C15orf57_uc001zma.1_Missense_Mutation_p.D139H|C15orf57_uc001zmb.1_Missense_Mutation_p.D130H|C15orf57_uc010bbr.2_Missense_Mutation_p.D128H	NM_001080792	NP_001074261	Q9BV29	CO057_HUMAN	coiled-coil domain containing 32 isoform a	130										ovary(1)	1						TCATCAGAATCAAGTCCATCC	0.438													12	26					0	0	0	0	G	40849428	G	G	40849428	3	3	214	1	0	0	0	0	1	0	0	0	1811	826	29	2	177	2	C15orf57	15	40849428	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	9511010	40849428	61681964	455	39345											
MAP1A	4130	broad.mit.edu	37	chr15	43815940	43815940	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcagatgaggagatccatGatgagccggaggagcgccca	11	6	14	10	2	1	5	1	3	1	2	3	8	2	7	3	3	2	0	3	3	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:43815940G>A	uc001zrt.2	+	4	2736	c.2269G>A	c.(2269-2271)GAT>AAT	p.D757N		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	757						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGAGATCCATGATGAGCCGGA	0.562													11	16					0	0	0	0	A	43815940	A	A	43815940	3	1	214	1	0	0	0	0	1	0	0	0	9280	1290	45	2	2271	2	MAP1A	15	43815940	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2966512	43815940	58715452	456	39346											
SLTM	79811	broad.mit.edu	37	chr15	59181735	59181735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttctcgagcaatccgttCagcttccttacgacgttcct	6	15	6	14	4	3	0	1	0	2	0	7	2	6	0	3	0	3	4	3	0	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:59181735C>T	uc002afp.2	-	16	2186	c.2098G>A	c.(2098-2100)GAA>AAA	p.E700K	SLTM_uc002afn.2_Missense_Mutation_p.E242K|SLTM_uc002afo.2_Missense_Mutation_p.E682K|SLTM_uc002afq.2_Missense_Mutation_p.E269K|SLTM_uc010bgd.2_Missense_Mutation_p.E269K	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	700	Arg/Glu-rich.|Potential.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						GCAATCCGTTCAGCTTCCTTA	0.408													14	23					0	0	0	0	T	59181735	T	T	59181735	3	4	214	1	0	0	0	0	1	0	0	0	14818	835	29	2	1030	2	SLTM	15	59181735	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	15365795	59181735	43349657	457	39347											
VPS13C	54832	broad.mit.edu	37	chr15	62228879	62228879	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgtgtagggcttggttgtGaggaagcttctccaagattt	8	14	13	6	0	1	2	0	1	1	1	2	3	1	3	1	3	1	4	1	3	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:62228879G>A	uc002agz.2	-	48	5746	c.5672C>T	c.(5671-5673)TCA>TTA	p.S1891L	VPS13C_uc002aha.2_Missense_Mutation_p.S1848L|VPS13C_uc002ahb.1_Missense_Mutation_p.S1891L|VPS13C_uc002ahc.1_Missense_Mutation_p.S1848L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1891					protein localization					ovary(2)	2						GCTTGGTTGTGAGGAAGCTTC	0.373													8	18					0	0	0	0	A	62228879	A	A	62228879	3	1	214	1	0	0	0	0	1	0	0	0	17259	1294	45	2	5769	2	VPS13C	15	62228879	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3047144	62228879	40302513	458	39348											
HERC1	8925	broad.mit.edu	37	chr15	63986220	63986220	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttttttttcttcttcttCaccgtcttcttgctcccctt	3	22	2	14	1	6	0	1	0	5	0	7	0	7	0	3	0	2	1	3	0	1	10			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ea8183de-8f9b-4d30-a23b-c6ffc183f22b	g.chr15:63986220C>T	uc002amp.2	-	30	5765	c.5617G>A	c.(5617-5619)GAA>AAA	p.E1873K		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1873					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						tcttcttcttcaccgtcttct	0.299													3	8					0	0	0	0	T	63986220	T	T	63986220	3	4	214	1	0	0	0	0	1	0	0	0	7096	835	29	2	9164	2	HERC1	15	63986220	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1757341	63986220	38545172	459	39349											
PLEKHO2	80301	broad.mit.edu	37	chr15	65152104	65152104	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcccacaggtcagcgacatCaaattccaggcacccaccgg	11	5	9	16	2	2	0	2	0	0	0	3	1	3	0	4	3	2	1	4	3	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:65152104C>G	uc002anv.2	+	4	425	c.291C>G	c.(289-291)ATC>ATG	p.I97M	PLEKHO2_uc010bgz.2_Intron|PLEKHO2_uc002anw.2_Missense_Mutation_p.I47M	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	97	PH.									ovary(1)|lung(1)	2						TCAGCGACATCAAATTCCAGG	0.488													37	157					0	0	0	0	G	65152104	G	G	65152104	3	3	214	1	0	0	0	0	1	0	0	0	12140	816	29	2	305	2	PLEKHO2	15	65152104	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1165884	65152104	37379288	460	39350											
UACA	55075	broad.mit.edu	37	chr15	70959538	70959538	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctctgccaggggtacagaaGagttcttttgattctccaac	9	12	10	10	0	3	3	0	1	3	2	4	3	3	3	2	2	3	3	2	2	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:70959538G>C	uc002asr.2	-	16	3589	c.3485C>G	c.(3484-3486)TCT>TGT	p.S1162C	UACA_uc010uke.1_Missense_Mutation_p.S1053C|UACA_uc002asq.2_Missense_Mutation_p.S1149C|UACA_uc010bin.1_Missense_Mutation_p.S1137C	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	1162	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						GGGTACAGAAGAGTTCTTTTG	0.398													64	134					0	0	0	0	C	70959538	C	C	70959538	3	2	214	1	0	0	0	0	1	0	0	0	16892	942	33	2	781	2	UACA	15	70959538	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5807434	70959538	31571854	461	39351											
GRAMD2	196996	broad.mit.edu	37	chr15	72460095	72460095	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttgatatccttgccaaaGaggctggcatggaagcagag	12	8	12	9	0	0	3	0	1	0	2	1	4	1	4	3	3	2	3	3	3	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:72460095G>T	uc002atq.2	-	5	378	c.354C>A	c.(352-354)CTC>CTA	p.L118L	GRAMD2_uc010bis.2_Silent_p.L118L	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	118	GRAM.					integral to membrane					0						CCTTGCCAAAGAGGCTGGCAT	0.597													16	63					6.94344e-10	7.43602e-10	1	0	T	72460095	T	T	72460095	2	4	214	1	0	0	0	0	0	0	0	1	6789	929	33	2		2	GRAMD2	15	72460095	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1500557	72460095	30071297	462	39352											
CELF6	60677	broad.mit.edu	37	chr15	72582528	72582528	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgatgtggccaaagggctGgaacaggcgtctgacgtcct	8	8	14	11	3	1	1	0	1	1	0	3	3	2	2	2	4	1	1	2	4	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:72582528G>A	uc002auh.2	-	4	773	c.463C>T	c.(463-465)CAG>TAG	p.Q155*	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010biw.2_Nonsense_Mutation_p.Q42*|CELF6_uc010ukl.1_Nonsense_Mutation_p.Q40*|CELF6_uc010ukm.1_Nonsense_Mutation_p.Q155*|CELF6_uc002aui.2_Nonsense_Mutation_p.Q261*|CELF6_uc002auj.2_Nonsense_Mutation_p.Q42*	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	155	RRM 2.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						CCAAAGGGCTGGAACAGGCGT	0.617													12	27					0	0	0	0	A	72582528	A	A	72582528	4	1	214	1	0	0	0	0	0	1	0	0	3235	1357	47	4	1018	4	CELF6	15	72582528	Nonsense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	122433	72582528	29948864	463	39353											
HEXA	3073	broad.mit.edu	37	chr15	72643480	72643480	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacgggaacatacctttctCatgagctctggaaaagtgaa	15	9	9	8	1	2	2	1	2	2	0	3	4	2	4	1	2	4	1	1	2	6	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:72643480C>A	uc002aun.3	-	6	873	c.666G>T	c.(664-666)ATG>ATT	p.M222I	uc002aug.2_RNA|CELF6_uc002auk.3_Intron|HEXA_uc010ukn.1_Missense_Mutation_p.M233I|HEXA_uc002auo.3_Missense_Mutation_p.M85I|HEXA_uc010bix.2_Missense_Mutation_p.M222I|HEXA_uc010biy.2_Missense_Mutation_p.M85I|HEXA_uc010uko.1_Missense_Mutation_p.M48I|HEXA_uc010biz.1_RNA	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	222					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			ovary(3)|upper_aerodigestive_tract(1)	4						ATACCTTTCTCATGAGCTCTG	0.468													10	38					7.03913e-09	7.49758e-09	1	0	A	72643480	A	A	72643480	3	1	214	1	0	0	0	0	1	0	0	0	7112	826	29	2	959	2	HEXA	15	72643480	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	60952	72643480	29887912	464	39354											
BBS4	585	broad.mit.edu	37	chr15	73002044	73002044	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaatatgctgcctagctcCagagtttcctattttggaga	11	13	8	9	0	0	2	0	0	0	2	2	3	2	2	3	1	3	3	3	1	5	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:73002044C>T	uc002avb.2	+	3	123	c.80C>T	c.(79-81)CCA>CTA	p.P27L	BBS4_uc010ukv.1_Missense_Mutation_p.P15L|BBS4_uc002avc.2_5'UTR|BBS4_uc002avd.2_Missense_Mutation_p.P35L	NM_033028	NP_149017	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	27	Required for localization to centrosomes.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity				0						TGCCTAGCTCCAGAGTTTCCT	0.358									Bardet-Biedl_syndrome				25	90					0	0	0	0	T	73002044	T	T	73002044	3	4	214	1	0	0	0	0	1	0	0	0	1341	594	21	4	90	4	BBS4	15	73002044	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	358564	73002044	29529348	465	39355											
CHRNA3	1136	broad.mit.edu	37	chr15	78894511	78894511	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggtcacgtcgattttacagGagctcttaaagatggccgga	11	10	12	8	3	2	1	1	0	1	1	3	4	2	3	1	4	2	1	1	4	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:78894511G>T	uc002bec.2	-	5	659	c.473C>A	c.(472-474)TCC>TAC	p.S158Y	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Missense_Mutation_p.S158Y	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	158	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						GATTTTACAGGAGCTCTTAAA	0.493													6	93					3.59834e-05	3.73637e-05	1	0	T	78894511	T	T	78894511	3	4	214	1	0	0	0	0	1	0	0	0	3399	1174	41	2	1137	2	CHRNA3	15	78894511	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5892467	78894511	23636881	466	39356											
RASGRF1	5923	broad.mit.edu	37	chr15	79296198	79296198	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaggggtcgtatcgccctCatctggaatcttgttggtga	6	13	12	10	2	4	1	2	1	2	0	6	2	4	2	1	4	0	2	1	4	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:79296198C>T	uc002beq.2	-	16	2818	c.2443G>A	c.(2443-2445)GAG>AAG	p.E815K	RASGRF1_uc002bep.2_Missense_Mutation_p.E799K|RASGRF1_uc010blm.1_Missense_Mutation_p.E724K|RASGRF1_uc002ber.3_Missense_Mutation_p.E799K|RASGRF1_uc010unh.1_Missense_Mutation_p.E210K|RASGRF1_uc002beo.2_Missense_Mutation_p.E31K	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	817					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GTATCGCCCTCATCTGGAATC	0.607													14	38					0	0	0	0	T	79296198	T	T	79296198	3	4	214	1	0	0	0	0	1	0	0	0	13137	835	29	2	1430	2	RASGRF1	15	79296198	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	401687	79296198	23235194	467	39357											
HOMER2	9455	broad.mit.edu	37	chr15	83518566	83518566	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagctcttcaactccaccttCaggtggcgctgtcggtattt	7	13	9	12	2	3	0	2	0	1	0	5	0	4	0	2	3	2	3	2	3	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:83518566C>T	uc002bjg.2	-	9	1152	c.966G>A	c.(964-966)CTG>CTA	p.L322L	HOMER2_uc002bjh.2_Silent_p.L311L|HOMER2_uc002bjj.2_Silent_p.L256L|HOMER2_uc002bji.2_Silent_p.L267L	NM_199330	NP_955362	Q9NSB8	HOME2_HUMAN	homer 2 isoform 2	322	Potential.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane					0						ACTCCACCTTCAGGTGGCGCT	0.547											OREG0023389	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	55					0	0	0	0	T	83518566	T	T	83518566	2	4	214	1	0	0	0	0	0	0	0	1	7318	813	29	2		2	HOMER2	15	83518566	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4222368	83518566	19012826	468	39358											
BTBD1	53339	broad.mit.edu	37	chr15	83687528	83687528	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttccttgaacatgaccctGaatgtgttagctgtcccatc	8	13	9	11	0	0	3	0	3	0	0	3	3	2	3	3	1	2	3	3	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:83687528G>A	uc002bjn.2	-	7	1424	c.1221C>T	c.(1219-1221)TTC>TTT	p.F407F	BTBD1_uc002bjo.2_Missense_Mutation_p.S378L	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	407						cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		ACATGACCCTGAATGTGTTAG	0.418													13	48					0	0	0	0	A	83687528	A	A	83687528	2	1	214	1	0	0	0	0	0	0	0	1	1542	1294	45	2		2	BTBD1	15	83687528	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	168962	83687528	18843864	469	39359											
ALPK3	57538	broad.mit.edu	37	chr15	85370749	85370749	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccatcattgctcagctcacaGaggagacccagccgctattt	10	9	8	14	1	3	2	3	0	0	2	3	3	3	2	3	1	3	3	3	1	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:85370749G>C	uc002ble.2	+	3	990	c.823G>C	c.(823-825)GAG>CAG	p.E275Q		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	275					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCAGCTCACAGAGGAGACCCA	0.562													6	46					0	0	0	0	C	85370749	C	C	85370749	3	2	214	1	0	0	0	0	1	0	0	0	546	943	33	2	833	2	ALPK3	15	85370749	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1683221	85370749	17160643	470	39360											
ALPK3	57538	broad.mit.edu	37	chr15	85405874	85405874	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttccccttcagttggagaaGagattgagatgacccctatg	10	11	11	9	0	1	4	1	2	0	3	2	7	2	4	4	1	0	2	4	1	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:85405874G>A	uc002ble.2	+	10	4911	c.4744G>A	c.(4744-4746)GAG>AAG	p.E1582K	ALPK3_uc010upc.1_5'Flank	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1582					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGTTGGAGAAGAGATTGAGAT	0.572													19	58					0	0	0	0	A	85405874	A	A	85405874	3	1	214	1	0	0	0	0	1	0	0	0	546	943	33	2	4782	2	ALPK3	15	85405874	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	35125	85405874	17125518	471	39361											
ALPK3	57538	broad.mit.edu	37	chr15	85407691	85407691	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggatcatcccactgtatctGatctaccggcctgcaaacaa	12	9	7	13	1	3	1	1	1	2	0	4	2	4	2	3	2	3	2	3	2	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:85407691G>A	uc002ble.2	+	12	5291	c.5124G>A	c.(5122-5124)CTG>CTA	p.L1708L	ALPK3_uc010upc.1_Silent_p.L9L	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1708	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CACTGTATCTGATCTACCGGC	0.527													35	59					0	0	0	0	A	85407691	A	A	85407691	2	1	214	1	0	0	0	0	0	0	0	1	546	1277	45	2		2	ALPK3	15	85407691	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1817	85407691	17123701	472	39362											
AKAP13	11214	broad.mit.edu	37	chr15	86118486	86118486	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctgagtctgattcacatCatgaacacccatttcctgga	10	12	6	13	0	4	3	2	3	2	0	5	4	5	4	3	1	1	0	3	1	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:86118486C>G	uc002blv.1	+	6	957	c.787C>G	c.(787-789)CAT>GAT	p.H263D	AKAP13_uc002blt.1_Missense_Mutation_p.H263D|AKAP13_uc002blu.1_Missense_Mutation_p.H263D	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	263					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						TGATTCACATCATGAACACCC	0.393													33	91					0	0	0	0	G	86118486	G	G	86118486	3	3	214	1	0	0	0	0	1	0	0	0	449	826	29	2	805	2	AKAP13	15	86118486	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	710795	86118486	16412906	473	39363											
C15orf42	90381	broad.mit.edu	37	chr15	90144539	90144539	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctctcaaggtgccagcttCaggtatttcttcgtttggag	6	16	10	9	1	4	0	2	0	2	0	6	1	4	1	1	3	2	3	1	3	2	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:90144539C>G	uc002boe.2	+	10	2164	c.2164C>G	c.(2164-2166)CAG>GAG	p.Q722E		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	722					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GTGCCAGCTTCAGGTATTTCT	0.373													6	34					0	0	0	0	G	90144539	G	G	90144539	3	3	214	1	0	0	0	0	1	0	0	0	1802	827	29	2	2202	2	C15orf42	15	90144539	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	4026053	90144539	12386853	474	39364											
CRTC3	64784	broad.mit.edu	37	chr15	91161162	91161162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagagaatctgttaaatgttCcgaagccactgccaaaacaa	17	8	7	9	1	1	1	0	0	1	1	2	3	2	1	3	0	3	2	3	0	8	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:91161162C>T	uc002bpp.2	+	8	767	c.661C>T	c.(661-663)CCG>TCG	p.P221S	CRTC3_uc002bpo.2_Missense_Mutation_p.P221S	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	221					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			GTTAAATGTTCCGAAGCCACT	0.433			T	MAML2	salivary gland mucoepidermoid								12	47					0	0	0	0	T	91161162	T	T	91161162	3	4	214	1	0	0	0	0	1	0	0	0	3916	855	30	2	691	2	CRTC3	15	91161162	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1016623	91161162	11370230	475	39365											
MAN2A2	4122	broad.mit.edu	37	chr15	91448544	91448544	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttttggaggagaaccatGagattatcagccatatcaag	14	10	10	7	0	2	2	2	1	0	2	2	5	2	3	2	2	3	1	2	2	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:91448544G>T	uc010bnz.2	+	3	311	c.196G>T	c.(196-198)GAG>TAG	p.E66*	MAN2A2_uc010boa.2_Nonsense_Mutation_p.E108*|MAN2A2_uc002bqc.2_Nonsense_Mutation_p.E66*|MAN2A2_uc010uql.1_5'Flank|MAN2A2_uc010uqm.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	66	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GGAGAACCATGAGATTATCAG	0.547													25	83					1.55469e-16	1.7069e-16	1	0	T	91448544	T	T	91448544	4	4	214	1	0	0	0	0	0	1	0	0	9268	1291	45	2	202	2	MAN2A2	15	91448544	Nonsense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	287382	91448544	11082848	476	39366											
IGF1R	3480	broad.mit.edu	37	chr15	99459287	99459287	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctctgcccaacggcaacctGagttactacattgtgcgctg	8	11	9	13	2	1	1	0	1	1	0	2	1	1	1	2	1	6	3	2	1	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:99459287G>C	uc002bul.2	+	9	1973	c.1923G>C	c.(1921-1923)CTG>CTC	p.L641L	IGF1R_uc010urq.1_Silent_p.L641L|IGF1R_uc010bon.2_Silent_p.L641L|IGF1R_uc010urr.1_Silent_p.L91L	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	641	Fibronectin type-III 2.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	ACGGCAACCTGAGTTACTACA	0.557													33	105					0	0	0	0	C	99459287	C	C	99459287	2	2	214	1	0	0	0	0	0	0	0	1	7610	1277	45	2		2	IGF1R	15	99459287	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	8010743	99459287	3072105	477	39367											
LASS3	204219	broad.mit.edu	37	chr15	100943007	100943007	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctttgcctttggtagcctCttcttcttcctcttcctctt	1	21	4	15	0	6	0	0	0	6	0	8	0	8	0	4	1	2	1	4	1	1	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr15:100943007C>G	uc002bvz.2	-	13	1565	c.1063G>C	c.(1063-1065)GAG>CAG	p.E355Q	LASS3_uc002bwa.2_Missense_Mutation_p.E366Q|LASS3_uc002bwb.2_Missense_Mutation_p.E355Q	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	355	Poly-Glu.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			TTGGTAGcctcttcttcttcc	0.408													7	23					0	0	0	0	G	100943007	G	G	100943007	3	3	214	1	0	0	0	0	1	0	0	0	8680	922	32	2	92	2	LASS3	15	100943007	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1483720	100943007	1588385	478	39368											
RHBDF1	64285	broad.mit.edu	37	chr16	111984	111984	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgctcaccacctcctgtcgGagccgcaccttgggctgcgg	4	8	13	16	3	1	0	1	0	0	0	3	1	2	1	5	3	3	3	5	3	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ea8183de-8f9b-4d30-a23b-c6ffc183f22b	g.chr16:111984G>A	uc002cfl.3	-	11	1168	c.1020C>T	c.(1018-1020)CTC>CTT	p.L340L	RHBDF1_uc010uty.1_Silent_p.L363L|RHBDF1_uc010utz.1_Silent_p.L340L|RHBDF1_uc010bqo.1_RNA	NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	340	Cytoplasmic (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				CCTCCTGTCGGAGCCGCACCT	0.741													7	10					0	0	0	0	A	111984	A	A	111984	2	1	214	1	0	0	0	0	0	0	0	1	13384	1161	41	2		2	RHBDF1	16	111984	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08		111984	90242769	479	39369											
MAPK8IP3	23162	broad.mit.edu	37	chr16	1797130	1797130	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccacatcctccgtgccctCggccgccgtcacacccctca	5	6	7	23	4	2	0	2	0	0	0	5	0	4	0	8	1	1	0	8	1	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:1797130C>T	uc002cmk.2	+	6	965	c.845C>T	c.(844-846)TCG>TTG	p.S282L	MAPK8IP3_uc002cmj.1_RNA|MAPK8IP3_uc002cml.2_Missense_Mutation_p.S282L|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.S283L	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	282					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						TCCGTGCCCTCGGCCGCCGTC	0.672													30	54					0	0	0	0	T	1797130	T	T	1797130	3	4	214	1	0	0	0	0	1	0	0	0	9339	893	31	1	867	1	MAPK8IP3	16	1797130	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1685146	1797130	88557623	480	39370											
C16orf89	146556	broad.mit.edu	37	chr16	5112511	5112511	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcccccagcatccccacGcgcaggctcagcggctgcag	6	6	10	19	3	2	0	1	0	1	0	4	0	3	0	4	2	3	5	4	2	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:5112511G>A	uc010bud.2	-	2	475	c.387C>T	c.(385-387)CGC>CGT	p.R129R	ALG1_uc002cyj.2_Intron|C16orf89_uc002cyk.3_Silent_p.R129R	NM_152459	NP_689672	Q6UX73	CP089_HUMAN	hypothetical protein LOC146556 isoform 1	91						extracellular region				ovary(1)|skin(1)	2						GCATCCCCACGCGCAGGCTCA	0.572													22	59					0	0	0	0	A	5112511	A	A	5112511	2	1	214	1	0	0	0	0	0	0	0	1	1848	1074	38	1		1	C16orf89	16	5112511	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3315381	5112511	85242242	481	39371											
ABAT	18	broad.mit.edu	37	chr16	8873373	8873373	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catcagcagggtgagaggacGaggcaccttttgctccttcg	8	9	13	11	2	1	1	1	1	0	1	3	4	2	2	2	3	2	3	2	3	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:8873373G>A	uc002czc.3	+	15	1473	c.1307G>A	c.(1306-1308)CGA>CAA	p.R436Q	ABAT_uc002czd.3_Missense_Mutation_p.R436Q|ABAT_uc010buh.2_Missense_Mutation_p.R378Q|ABAT_uc010bui.2_Missense_Mutation_p.R436Q	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	436					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	GTGAGAGGACGAGGCACCTTT	0.532													8	51					0	0	0	0	A	8873373	A	A	8873373	3	1	214	1	0	0	0	0	1	0	0	0	27	1058	37	1	1361	1	ABAT	16	8873373	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3760862	8873373	81481380	482	39372											
ABAT	18	broad.mit.edu	37	chr16	8875251	8875251	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccacgctcacctgttcctCaatattttcagtgacatctt	9	14	4	14	1	4	1	3	1	1	0	5	1	5	1	3	0	0	2	3	0	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:8875251C>A	uc002czc.3	+	16	1633	c.1467C>A	c.(1465-1467)CTC>CTA	p.L489L	ABAT_uc002czd.3_Silent_p.L489L|ABAT_uc010buh.2_Silent_p.L431L|ABAT_uc010bui.2_Silent_p.L489L	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	489					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	ACCTGTTCCTCAATATTTTCA	0.478													20	53					5.03518e-11	5.41455e-11	1	0	A	8875251	A	A	8875251	2	1	214	1	0	0	0	0	0	0	0	1	27	813	29	2		2	ABAT	16	8875251	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1878	8875251	81479502	483	39373											
SMG1	23049	broad.mit.edu	37	chr16	18865140	18865140	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagctttcacagacttgcaGaaagatatggcacaagaact	15	9	8	9	0	2	4	2	0	0	4	2	4	2	4	0	1	3	3	0	1	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:18865140G>C	uc002dfm.2	-	31	4896	c.4533C>G	c.(4531-4533)TTC>TTG	p.F1511L	SMG1_uc010bwb.2_Missense_Mutation_p.F1371L|SMG1_uc010bwa.2_Missense_Mutation_p.F242L	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1511	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CAGACTTGCAGAAAGATATGG	0.403													11	24					0	0	0	0	C	18865140	C	C	18865140	3	2	214	1	0	0	0	0	1	0	0	0	14859	933	33	2	6584	2	SMG1	16	18865140	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9989889	18865140	71489613	484	39374											
C16orf62	57020	broad.mit.edu	37	chr16	19659193	19659193	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctggagcctgttcttgtgCagttgattcatgtaagtatt	8	17	10	6	0	3	1	1	1	2	0	3	2	3	2	1	1	2	5	1	1	2	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:19659193C>T	uc002dgn.1	+	24	2029	c.2017C>T	c.(2017-2019)CAG>TAG	p.Q673*	C16orf62_uc002dgo.1_Nonsense_Mutation_p.Q606*|C16orf62_uc002dgp.1_Nonsense_Mutation_p.Q422*	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	673						integral to membrane				ovary(1)	1						TGTTCTTGTGCAGTTGATTCA	0.323													24	76					0	0	0	0	T	19659193	T	T	19659193	4	4	214	1	0	0	0	0	0	1	0	0	1831	711	25	4	2111	4	C16orf62	16	19659193	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	794053	19659193	70695560	485	39375											
IL4R	3566	broad.mit.edu	37	chr16	27375021	27375021	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccggcctccctggcaccctCgggcatctcagagaagagta	8	7	11	15	2	1	2	1	0	1	2	5	3	3	2	4	3	0	3	4	3	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:27375021C>T	uc002don.2	+	11	2590	c.2348C>T	c.(2347-2349)TCG>TTG	p.S783L	IL4R_uc002dop.3_Missense_Mutation_p.S768L|IL4R_uc010bxy.2_Missense_Mutation_p.S783L|IL4R_uc002doo.2_Missense_Mutation_p.S623L	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	783	Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						CTGGCACCCTCGGGCATCTCA	0.612													19	57					0	0	0	0	T	27375021	T	T	27375021	3	4	214	1	0	0	0	0	1	0	0	0	7737	893	31	1	2400	1	IL4R	16	27375021	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	7715828	27375021	62979732	486	39376											
KIAA0556	23247	broad.mit.edu	37	chr16	27789012	27789012	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggcatcctgcccacatgtGagcccaccgtgccctaccac	7	6	10	18	1	0	1	0	1	0	0	1	1	1	1	6	2	4	1	6	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:27789012G>C	uc002dow.2	+	26	4657	c.4633G>C	c.(4633-4635)GAG>CAG	p.E1545Q	KIAA0556_uc010vco.1_Missense_Mutation_p.E47Q	NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1545										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						GCCCACATGTGAGCCCACCGT	0.647													26	93					0	0	0	0	C	27789012	C	C	27789012	3	2	214	1	0	0	0	0	1	0	0	0	8222	1291	45	2	4735	2	KIAA0556	16	27789012	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	413991	27789012	62565741	487	39377											
LAT	27040	broad.mit.edu	37	chr16	28997455	28997455	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacttggttctgtgtcctcaGacacggttgccccctggcca	6	11	10	14	1	2	1	1	0	1	1	3	1	3	1	4	3	2	2	4	3	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:28997455G>C	uc002dsd.2	+	4	516	c.164_splice	c.e4-1	p.H55_splice	uc010vct.1_Intron|LAT_uc010vdj.1_Splice_Site_p.H91_splice|LAT_uc002dsb.2_Splice_Site_p.H55_splice|LAT_uc002dsc.2_Splice_Site_p.H55_splice|LAT_uc010vdk.1_Splice_Site_p.H55_splice|LAT_uc010vdl.1_Splice_Site_p.H55_splice	NM_014387	NP_055202	O43561	LAT_HUMAN	linker for activation of T cells isoform a						calcium-mediated signaling|integrin-mediated signaling pathway|mast cell degranulation|platelet activation|Ras protein signal transduction|regulation of T cell activation|T cell receptor signaling pathway	immunological synapse|integral to membrane|intracellular|membrane raft	SH3/SH2 adaptor activity				0		Hepatocellular(780;0.244)				TGTGTCCTCAGACACGGTTGC	0.612													36	83					0	0	0	0	C	28997455	C	C	28997455	5	2	214	1	0	0	0	0	0	0	1	0	8684	956	33	2	289	2	LAT	16	28997455	Splice_Site	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1208443	28997455	61357298	488	39378											
TAOK2	9344	broad.mit.edu	37	chr16	29994478	29994478	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagcatgtccatcagcgcctCcagccagagcagctccgtca	9	6	9	17	2	2	1	2	0	0	1	5	1	5	1	5	0	5	3	5	0	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:29994478C>G	uc002dva.1	+	12	1868	c.1085C>G	c.(1084-1086)TCC>TGC	p.S362C	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.S362C|TAOK2_uc002dvc.1_Missense_Mutation_p.S362C|TAOK2_uc010bzm.1_Missense_Mutation_p.S369C|TAOK2_uc002dvd.1_Missense_Mutation_p.S189C	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	362	Ser-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						ATCAGCGCCTCCAGCCAGAGC	0.498													42	96					0	0	0	0	G	29994478	G	G	29994478	3	3	214	1	0	0	0	0	1	0	0	0	15614	855	30	2	1127	2	TAOK2	16	29994478	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	997023	29994478	60360275	489	39379											
TAOK2	9344	broad.mit.edu	37	chr16	29994909	29994909	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcagccccagctcccacttCcaccacctcttccgcccgcc	5	7	5	24	2	1	0	0	0	1	0	4	0	4	0	9	0	3	2	9	0	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:29994909C>T	uc002dva.1	+	13	2129	c.1346C>T	c.(1345-1347)TCC>TTC	p.S449F	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.S449F|TAOK2_uc002dvc.1_Missense_Mutation_p.S449F|TAOK2_uc010bzm.1_Missense_Mutation_p.S456F|TAOK2_uc002dvd.1_Missense_Mutation_p.S276F	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	449					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GCTCCCACTTCCACCACCTCT	0.622													9	466					0	0	0	0	T	29994909	T	T	29994909	3	4	214	1	0	0	0	0	1	0	0	0	15614	855	30	2	1392	2	TAOK2	16	29994909	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	431	29994909	60359844	490	39380											
GDPD3	79153	broad.mit.edu	37	chr16	30116264	30116264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggataatccgttatgaCgccagtggctcccacgctga	8	10	12	11	3	0	2	0	2	0	0	2	3	2	3	3	2	0	3	3	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:30116264C>T	uc002dwp.2	-	10	965	c.886G>A	c.(886-888)GTC>ATC	p.V296I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002dwo.1_RNA|GDPD3_uc002dwq.2_Missense_Mutation_p.V234I	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	296	GDPD.|Cytoplasmic (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						TCCGTTATGACGCCAGTGGCT	0.567													15	43					0	0	0	0	T	30116264	T	T	30116264	3	4	214	1	0	0	0	0	1	0	0	0	6362	536	19	1	74	1	GDPD3	16	30116264	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	121355	30116264	60238489	491	39381											
SRCAP	10847	broad.mit.edu	37	chr16	30749759	30749759	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgcagcatgtcagggccaGaatcctcccctcccattggt	7	9	9	16	1	1	1	1	0	0	1	5	1	5	1	6	2	1	2	6	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:30749759G>C	uc002dze.1	+	34	8783	c.8398G>C	c.(8398-8400)GAA>CAA	p.E2800Q	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.E2595Q	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2800	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GTCAGGGCCAGAATCCTCCCC	0.652													4	76					0	0	0	0	C	30749759	C	C	30749759	3	2	214	1	0	0	0	0	1	0	0	0	15201	943	33	2	8524	2	SRCAP	16	30749759	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	633495	30749759	59604994	492	39382											
BCKDK	10295	broad.mit.edu	37	chr16	31121565	31121565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggcccagtactgccagctgGtgcgacagctgctggatgac	8	7	14	12	1	0	1	0	1	0	0	0	3	0	2	2	3	6	4	2	3	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:31121565G>A	uc002eaw.3	+	6	779	c.463G>A	c.(463-465)GTG>ATG	p.V155M	BCKDK_uc002eav.3_Missense_Mutation_p.V155M|BCKDK_uc010cah.2_RNA|BCKDK_uc010cai.2_Missense_Mutation_p.V155M	NM_005881	NP_005872	O14874	BCKD_HUMAN	branched chain ketoacid dehydrogenase kinase	155					branched chain family amino acid catabolic process|peptidyl-histidine phosphorylation	mitochondrial alpha-ketoglutarate dehydrogenase complex	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity|ATP binding|protein binding|protein serine/threonine kinase activity|two-component sensor activity			stomach(1)|breast(1)	2						CTGCCAGCTGGTGCGACAGCT	0.607													18	66					0	0	0	0	A	31121565	A	A	31121565	3	1	214	1	0	0	0	0	1	0	0	0	1363	1261	44	4	481	4	BCKDK	16	31121565	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	371806	31121565	59233188	493	39383											
BCKDK	10295	broad.mit.edu	37	chr16	31121725	31121725	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacctcactctttacaggatGaaaagctcgtccgctacttc	10	11	7	13	2	2	1	1	1	1	0	5	3	3	2	2	1	3	2	2	1	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:31121725G>A	uc002eaw.3	+	7	863	c.547G>A	c.(547-549)GAA>AAA	p.E183K	BCKDK_uc002eav.3_Missense_Mutation_p.E183K|BCKDK_uc010cah.2_RNA|BCKDK_uc010cai.2_Missense_Mutation_p.E183K	NM_005881	NP_005872	O14874	BCKD_HUMAN	branched chain ketoacid dehydrogenase kinase	183	Histidine kinase.				branched chain family amino acid catabolic process|peptidyl-histidine phosphorylation	mitochondrial alpha-ketoglutarate dehydrogenase complex	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity|ATP binding|protein binding|protein serine/threonine kinase activity|two-component sensor activity			stomach(1)|breast(1)	2						TTTACAGGATGAAAAGCTCGT	0.592													20	59					0	0	0	0	A	31121725	A	A	31121725	3	1	214	1	0	0	0	0	1	0	0	0	1363	1291	45	2	569	2	BCKDK	16	31121725	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	160	31121725	59233028	494	39384											
PYCARD	29108	broad.mit.edu	37	chr16	31213943	31213943	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accgacagcagcttcagcttGaacttcttgagctcctcggc	8	10	9	14	2	2	2	1	2	1	0	4	3	3	2	2	1	5	4	2	1	1	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:31213943G>A	uc010cak.2	-	1	309	c.69C>T	c.(67-69)TTC>TTT	p.F23F	PYCARD_uc002ebm.2_Silent_p.F23F	NM_013258	NP_037390	Q9ULZ3	ASC_HUMAN	PYD and CARD domain containing isoform a	23	DAPIN.				induction of apoptosis|positive regulation of interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex	caspase activator activity|cysteine-type endopeptidase activity|protein homodimerization activity|Pyrin domain binding				0						GCTTCAGCTTGAACTTCTTGA	0.706													8	42					0	0	0	0	A	31213943	A	A	31213943	2	1	214	1	0	0	0	0	0	0	0	1	12919	1281	45	2		2	PYCARD	16	31213943	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	92218	31213943	59140810	495	39385											
KATNB1	10300	broad.mit.edu	37	chr16	57786709	57786709	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagcgtcctcttcaacccaGacggctgctgcctgtacagc	7	8	11	15	2	2	1	1	0	1	1	3	2	3	2	3	2	6	3	3	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:57786709G>C	uc002eml.1	+	10	1098	c.724G>C	c.(724-726)GAC>CAC	p.D242H		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	242	WD 6.|Interaction with centrosomes.|Interaction with dynein (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				CTTCAACCCAGACGGCTGCTG	0.657													4	28					0	0	0	0	C	57786709	C	C	57786709	3	2	214	1	0	0	0	0	1	0	0	0	8026	942	33	2	758	2	KATNB1	16	57786709	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	26572766	57786709	32568044	496	39386											
ELMO3	79767	broad.mit.edu	37	chr16	67237075	67237075	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaagctgctgcagtacggaGacatggaggagggcgccagc	11	4	16	10	2	0	1	0	0	0	1	0	4	0	3	1	4	5	4	1	4	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:67237075G>C	uc002esa.2	+	17	1931	c.1888G>C	c.(1888-1890)GAC>CAC	p.D630H	ELMO3_uc002esb.2_Missense_Mutation_p.D613H|ELMO3_uc002esc.2_Missense_Mutation_p.D464H|uc010vjf.1_5'Flank|MIR328_hsa-mir-328|MI0000804_5'Flank	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	577	PH.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		GCAGTACGGAGACATGGAGGA	0.647													10	26					0	0	0	0	C	67237075	C	C	67237075	3	2	214	1	0	0	0	0	1	0	0	0	5091	942	33	2	1954	2	ELMO3	16	67237075	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9450366	67237075	23117678	497	39387											
TMCO7	79613	broad.mit.edu	37	chr16	68961608	68961608	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacccatggagcctttgcCactgaggccgtcagcatggc	7	9	11	14	1	2	1	1	1	1	0	2	2	2	2	4	3	4	1	4	3	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:68961608C>A	uc002ewi.3	+	13	2277	c.2265C>A	c.(2263-2265)GCC>GCA	p.A755A		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	755						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		GAGCCTTTGCCACTGAGGCCG	0.502													14	140					1.05317e-09	1.12481e-09	1	0	A	68961608	A	A	68961608	2	1	214	1	0	0	0	0	0	0	0	1	16067	581	21	4		4	TMCO7	16	68961608	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1724533	68961608	21393145	498	39388											
WWP2	11060	broad.mit.edu	37	chr16	69874159	69874159	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcctaatggcagtgccctGacagatggtgagtgccgccc	7	8	14	12	1	0	3	0	2	0	1	0	3	0	3	4	2	3	1	4	2	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ea8183de-8f9b-4d30-a23b-c6ffc183f22b	g.chr16:69874159G>C	uc002exu.1	+	6	560	c.471G>C	c.(469-471)CTG>CTC	p.L157L	WWP2_uc002ext.2_Silent_p.L157L|WWP2_uc002exv.1_Silent_p.L157L|WWP2_uc010vlm.1_Silent_p.L41L	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	157					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						GCAGTGCCCTGACAGATGGTG	0.602													3	68					0	0	0	0	C	69874159	C	C	69874159	2	2	214	1	0	0	0	0	0	0	0	1	17484	1277	45	2		2	WWP2	16	69874159	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	912551	69874159	20480594	499	39389											
ZNF19	7567	broad.mit.edu	37	chr16	71512138	71512138	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcctcacctacctttacaGacgtttttggtcctctctgc	5	15	6	15	1	2	1	1	0	1	1	4	1	3	1	4	1	4	1	4	1	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:71512138G>A	uc010cgc.1	-	5	773	c.267C>T	c.(265-267)GTC>GTT	p.V89V	ZNF23_uc002fai.2_5'UTR|ZNF19_uc002fak.1_Silent_p.V77V|ZNF19_uc002fal.1_Silent_p.V77V|ZNF19_uc002fam.1_Silent_p.V89V	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	89						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		TACCTTTACAGACGTTTTTGG	0.448													8	34					0	0	0	0	A	71512138	A	A	71512138	2	1	214	1	0	0	0	0	0	0	0	1	17822	929	33	2		2	ZNF19	16	71512138	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1637979	71512138	18842615	500	39390											
ATMIN	23300	broad.mit.edu	37	chr16	81078338	81078338	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagacccaaactgaaggagtCtccactgctaaaaatatacc	16	7	7	11	0	1	2	0	1	1	1	2	4	1	3	3	1	3	1	3	1	7	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:81078338C>G	uc002ffz.1	+	4	2253	c.2235C>G	c.(2233-2235)GTC>GTG	p.V745V	ATMIN_uc002fga.2_Silent_p.V587V|ATMIN_uc010vnn.1_Silent_p.V516V|ATMIN_uc002fgb.1_Silent_p.V587V	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	745					response to DNA damage stimulus	nucleus	zinc ion binding				0						CTGAAGGAGTCTCCACTGCTA	0.453													10	97					0	0	0	0	G	81078338	G	G	81078338	2	3	214	1	0	0	0	0	0	0	0	1	1112	900	32	2		2	ATMIN	16	81078338	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	9566200	81078338	9276415	501	39391											
GAN	8139	broad.mit.edu	37	chr16	81388253	81388253	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattcttagagctgagtcctCaaaagcttaaagaagtgatt	15	12	8	6	0	2	4	1	2	1	2	3	4	3	4	1	0	2	2	1	0	7	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:81388253C>G	uc002fgo.2	+	3	674	c.526C>G	c.(526-528)CAA>GAA	p.Q176E		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	176	BACK.				cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				GCTGAGTCCTCAAAAGCTTAA	0.408													21	50					0	0	0	0	G	81388253	G	G	81388253	3	3	214	1	0	0	0	0	1	0	0	0	6267	827	29	2	536	2	GAN	16	81388253	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	309915	81388253	8966500	502	39392											
CDH13	1012	broad.mit.edu	37	chr16	83636065	83636065	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cttgtgctttgtagactctgGaaaatcccaagtatgaactg	11	13	9	8	0	1	2	0	1	1	1	2	3	2	3	1	1	2	3	1	1	6	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:83636065G>C	uc002fgx.2	+	8	1087	c.967G>C	c.(967-969)GAA>CAA	p.E323Q	CDH13_uc010vns.1_Missense_Mutation_p.E370Q|CDH13_uc010vnt.1_Missense_Mutation_p.E69Q|CDH13_uc010vnu.1_Missense_Mutation_p.E284Q	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	323	Cadherin 2.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GTAGACTCTGGAAAATCCCAA	0.463													67	241					0	0	0	0	C	83636065	C	C	83636065	3	2	214	1	0	0	0	0	1	0	0	0	3114	1175	41	2	997	2	CDH13	16	83636065	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2247812	83636065	6718688	503	39393											
FANCA	2175	broad.mit.edu	37	chr16	89858379	89858379	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaagcagacaaccagggcaGacacaaaggagagcactctc	17	2	11	11	0	1	3	0	0	1	3	2	5	1	3	1	2	3	3	1	2	3	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:89858379G>C	uc002fou.1	-	13	1223	c.1181C>G	c.(1180-1182)TCT>TGT	p.S394C	FANCA_uc010vpn.1_Missense_Mutation_p.S394C	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	394					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		AACCAGGGCAGACACAAAGGA	0.552			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				15	48					0	0	0	0	C	89858379	C	C	89858379	3	2	214	1	0	0	0	0	1	0	0	0	5694	942	33	2	3310	2	FANCA	16	89858379	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6222314	89858379	496374	504	39394											
SPIRE2	84501	broad.mit.edu	37	chr16	89930015	89930015	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcagcagtctgaagaagggGaaggtgaggctgcctagacg	11	7	16	7	1	2	4	1	2	1	2	2	5	2	5	1	4	2	2	1	4	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr16:89930015G>T	uc002foz.1	+	11	1759	c.1707G>T	c.(1705-1707)GGG>GGT	p.G569G	SPIRE2_uc010ciw.1_Silent_p.G569G|SPIRE2_uc002fpa.1_Silent_p.G521G|SPIRE2_uc010cix.1_Silent_p.G436G	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	569					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		TGAAGAAGGGGAAGGTGAGGC	0.587													12	60					3.07112e-06	3.21016e-06	1	0	T	89930015	T	T	89930015	2	4	214	1	0	0	0	0	0	0	0	1	15138	1161	41	2		2	SPIRE2	16	89930015	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	71636	89930015	424738	505	39395											
ZZEF1	23140	broad.mit.edu	37	chr17	4009037	4009037	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttccagcacattaggggaGaggaaagttgagaaatctgt	13	10	12	6	0	2	2	0	1	2	2	3	5	3	3	1	3	1	2	1	3	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:4009037G>C	uc002fxe.2	-	7	1408	c.1344C>G	c.(1342-1344)CTC>CTG	p.L448L	ZZEF1_uc002fxk.1_Silent_p.L448L	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	448							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CATTAGGGGAGAGGAAAGTTG	0.453													15	40					0	0	0	0	C	4009037	C	C	4009037	2	2	214	1	0	0	0	0	0	0	0	1	18322	929	33	2		2	ZZEF1	17	4009037	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08		4009037	77186173	506	39396											
XAF1	54739	broad.mit.edu	37	chr17	6665494	6665494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaaagaatttcagctcctGaaagggaaatctactgtcat	14	10	10	7	0	3	2	2	1	1	1	4	4	4	4	1	2	2	1	1	2	5	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:6665494G>A	uc002gdn.2	+	5	684	c.442G>A	c.(442-444)GAA>AAA	p.E148K	XAF1_uc002gdm.1_Missense_Mutation_p.E88K|XAF1_uc002gdo.2_Missense_Mutation_p.E129K|XAF1_uc002gdp.2_Intron|XAF1_uc002gdq.2_5'UTR|XAF1_uc002gdr.2_Intron	NM_017523	NP_059993	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1 isoform 1	148					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding				0						TTCAGCTCCTGAAAGGGAAAT	0.408													12	19					0	0	0	0	A	6665494	A	A	6665494	3	1	214	1	0	0	0	0	1	0	0	0	17487	1291	45	2	460	2	XAF1	17	6665494	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2656457	6665494	74529716	507	39397											
PHF23	79142	broad.mit.edu	37	chr17	7139717	7139717	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcggtccttctttcgaggagGatgggagaggtccccctggg	5	10	16	10	2	1	1	0	0	1	1	5	5	3	3	3	6	0	0	3	6	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:7139717G>A	uc002gfa.2	-	4	756	c.529C>T	c.(529-531)CCT>TCT	p.P177S	DVL2_uc002gez.1_5'Flank|DVL2_uc010vtr.1_5'Flank|DVL2_uc010clz.1_5'Flank|PHF23_uc010vtt.1_Missense_Mutation_p.P110S|PHF23_uc010cma.2_Missense_Mutation_p.P47S	NM_024297	NP_077273	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	177							zinc ion binding				0						TTTCGAGGAGGATGGGAGAGG	0.632													21	49					0	0	0	0	A	7139717	A	A	7139717	3	1	214	1	0	0	0	0	1	0	0	0	11890	1174	41	2	690	2	PHF23	17	7139717	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	474223	7139717	74055493	508	39398											
KDM6B	23135	broad.mit.edu	37	chr17	7752328	7752328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctatctctgccccctgctCgctctgagtctgaggtgcta	4	12	9	16	1	3	2	0	2	3	0	5	2	3	2	3	1	3	3	3	1	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:7752328C>T	uc002giw.1	+	11	3098	c.2722C>T	c.(2722-2724)CGC>TGC	p.R908C	KDM6B_uc002gix.2_Missense_Mutation_p.R210C	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	908					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						GCCCCCTGCTCGCTCTGAGTC	0.711													6	11					0	0	0	0	T	7752328	T	T	7752328	3	4	214	1	0	0	0	0	1	0	0	0	8177	884	31	1	2752	1	KDM6B	17	7752328	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	612611	7752328	73442882	509	39399											
RICH2	9912	broad.mit.edu	37	chr17	12823101	12823101	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccaaatattcaaaagcagagGaaacacttagccaagttggt	17	8	8	8	0	1	1	1	0	0	1	1	2	1	2	2	2	3	2	2	2	7	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:12823101G>A	uc002gnr.3	+	6	744	c.417G>A	c.(415-417)AGG>AGA	p.R139R	RICH2_uc010vvk.1_Silent_p.R139R|RICH2_uc010vvl.1_Silent_p.R139R|RICH2_uc002gns.3_5'UTR|RICH2_uc010vvm.1_Silent_p.R139R|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	139	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						AAAAGCAGAGGAAACACTTAG	0.368													3	12					0	0	0	0	A	12823101	A	A	12823101	2	1	214	1	0	0	0	0	0	0	0	1	13422	1165	41	2		2	RICH2	17	12823101	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	5070773	12823101	68372109	510	39400											
RASD1	51655	broad.mit.edu	37	chr17	17398763	17398763	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcttcttggccgagatctcGaagtaggcgcagcgctgggg	6	10	15	10	4	3	1	0	0	3	1	4	3	3	1	1	4	1	3	1	4	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:17398763G>A	uc002gri.2	-	2	734	c.522C>T	c.(520-522)TTC>TTT	p.F174F		NM_016084	NP_057168	Q9Y272	RASD1_HUMAN	RAS, dexamethasone-induced 1 precursor	174					G-protein coupled receptor protein signaling pathway|small GTPase mediated signal transduction	nucleus|perinuclear region of cytoplasm|plasma membrane	GTP binding|GTPase activity				0						CCGAGATCTCGAAGTAGGCGC	0.647													5	9					0	0	0	0	A	17398763	A	A	17398763	2	1	214	1	0	0	0	0	0	0	0	1	13131	1049	37	1		1	RASD1	17	17398763	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4575662	17398763	63796447	511	39401											
ATPAF2	91647	broad.mit.edu	37	chr17	17921887	17921887	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccttcaggagcttgtgcttGactgtggtgctctcggagca	5	13	13	10	1	2	1	1	1	1	0	4	3	3	3	1	3	4	4	1	3	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:17921887G>C	uc002gse.1	-	8	999	c.846C>G	c.(844-846)GTC>GTG	p.V282V	ATPAF2_uc002gsd.1_Intron|ATPAF2_uc002gsf.1_RNA	NM_145691	NP_663729	Q8N5M1	ATPF2_HUMAN	ATP synthase mitochondrial F1 complex assembly	282					proton-transporting ATP synthase complex assembly	mitochondrion|nuclear speck	protein binding				0	all_neural(463;0.228)					GCTTGTGCTTGACTGTGGTGC	0.642													25	74					0	0	0	0	C	17921887	C	C	17921887	2	2	214	1	0	0	0	0	0	0	0	1	1203	1277	45	2		2	ATPAF2	17	17921887	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	523124	17921887	63273323	512	39402											
UNC119	9094	broad.mit.edu	37	chr17	26879514	26879514	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggggccacgctctggcccGagggccccggagcggactcc	4	4	17	16	4	1	0	0	0	1	0	2	3	2	2	5	6	1	1	5	6	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:26879514G>A	uc002hbk.2	-	1	133	c.62C>T	c.(61-63)TCG>TTG	p.S21L	UNC119_uc002hbm.2_Missense_Mutation_p.S21L	NM_005148	NP_005139	Q13432	U119A_HUMAN	unc119 (C.elegans) homolog isoform a	21					phototransduction|synaptic transmission|visual perception	cytosol|soluble fraction					0	Lung NSC(42;0.00431)					GCTCTGGCCCGAGGGCCCCGG	0.761													3	9					0	0	0	0	A	26879514	A	A	26879514	3	1	214	1	0	0	0	0	1	0	0	0	17050	1059	37	1	733	1	UNC119	17	26879514	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	8957627	26879514	54315696	513	39403											
SUPT6H	6830	broad.mit.edu	37	chr17	27001375	27001375	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggctttatcaatgacgatGatgatgaagatgaaggggag	15	9	14	3	1	1	6	1	5	0	1	1	8	1	7	0	3	0	1	0	3	5	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:27001375G>C	uc002hby.2	+	3	274	c.184G>C	c.(184-186)GAT>CAT	p.D62H	SUPT6H_uc010crt.2_Missense_Mutation_p.D62H	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	62	Asp/Glu-rich.			DDDEDEGEEDEGS -> ATAPGHPKLSEGR (in Ref. 1; AAC50821).	chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					CAATGACGATGATGATGAAGA	0.473													10	27					0	0	0	0	C	27001375	C	C	27001375	3	2	214	1	0	0	0	0	1	0	0	0	15466	1290	45	2	190	2	SUPT6H	17	27001375	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	121861	27001375	54193835	514	39404											
PHF12	57649	broad.mit.edu	37	chr17	27244465	27244465	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgtcatattcttctggttCagctagggacaaagcagaca	12	11	10	8	0	4	1	2	0	2	1	4	2	4	2	0	2	2	3	0	2	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:27244465C>G	uc002hdg.1	-	7	1502	c.972G>C	c.(970-972)CTG>CTC	p.L324L	PHF12_uc010wbb.1_Silent_p.L306L|PHF12_uc002hdi.1_Silent_p.L320L|PHF12_uc002hdj.1_Silent_p.L324L|PHF12_uc010crw.1_Silent_p.L27L|PHF12_uc002hdh.1_Silent_p.L107L	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	324	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TCTTCTGGTTCAGCTAGGGAC	0.493													11	47					0	0	0	0	G	27244465	G	G	27244465	2	3	214	1	0	0	0	0	0	0	0	1	11878	813	29	2		2	PHF12	17	27244465	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	243090	27244465	53950745	515	39405											
CPD	1362	broad.mit.edu	37	chr17	28789469	28789469	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatttggtttgccaagggagCttgtggtaactgtatcaggt	8	15	13	5	0	1	0	1	0	0	0	1	1	1	1	1	4	3	4	1	4	4	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:28789469C>G	uc002hfb.1	+	20	3913	c.3898C>G	c.(3898-3900)CTT>GTT	p.L1300V	CPD_uc010wbo.1_Missense_Mutation_p.L1053V|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	1300	Helical; (Potential).				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						GCCAAGGGAGCTTGTGGTAAC	0.373													20	49					0	0	0	0	G	28789469	G	G	28789469	3	3	214	1	0	0	0	0	1	0	0	0	3813	797	28	4	3976	4	CPD	17	28789469	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1545004	28789469	52405741	516	39406											
LRRC37B	114659	broad.mit.edu	37	chr17	30376383	30376383	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attaatgagaacatggaacaGaatgaacagaaagagcagaa	22	5	10	4	0	0	6	0	2	0	5	0	8	0	7	0	1	4	1	0	1	7	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:30376383G>C	uc002hgu.2	+	10	2657	c.2646G>C	c.(2644-2646)CAG>CAC	p.Q882H	LRRC37B_uc010wbx.1_Missense_Mutation_p.Q800H|LRRC37B_uc010csu.2_Missense_Mutation_p.Q831H	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	882	Potential.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				ACATGGAACAGAATGAACAGA	0.433													4	9					0	0	0	0	C	30376383	C	C	30376383	3	2	214	1	0	0	0	0	1	0	0	0	9044	933	33	2	2684	2	LRRC37B	17	30376383	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1586914	30376383	50818827	517	39407											
CCL2	6347	broad.mit.edu	37	chr17	32583786	32583786	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctgtgctgaccccaagcaGaagtgggttcaggattccat	10	10	11	10	0	2	2	1	1	1	1	3	3	3	3	3	2	2	3	3	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:32583786G>C	uc002hhy.2	+	3	313	c.240G>C	c.(238-240)CAG>CAC	p.Q80H		NM_002982	NP_002973	P13500	CCL2_HUMAN	small inducible cytokine A2 precursor	80				Missing: 90% reduction in activity.|Missing: 83% reduction in activity.	angiogenesis|anti-apoptosis|apoptotic cell clearance|astrocyte cell migration|cell adhesion|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|G-protein signaling, coupled to cyclic nucleotide second messenger|helper T cell extravasation|humoral immune response|inflammatory response|JAK-STAT cascade|macrophage chemotaxis|monocyte chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of T cell activation|viral genome replication	extracellular space	CCR2 chemokine receptor binding|chemokine activity|protein kinase activity|signal transducer activity			pancreas(1)	1	Breast(3;0.00224)	Ovarian(249;0.0694)|Breast(31;0.151)|Lung NSC(157;0.153)		UCEC - Uterine corpus endometrioid carcinoma (308;0.000241)|BRCA - Breast invasive adenocarcinoma(366;0.0103)	Atorvastatin(DB01076)|Danazol(DB01406)|Mimosine(DB01055)|Simvastatin(DB00641)	ACCCCAAGCAGAAGTGGGTTC	0.488													20	38					0	0	0	0	C	32583786	C	C	32583786	3	2	214	1	0	0	0	0	1	0	0	0	2904	933	33	2	250	2	CCL2	17	32583786	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2207403	32583786	48611424	518	39408											
GPR179	440435	broad.mit.edu	37	chr17	36499096	36499096	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttcttcagggcaggggtgtCcaggtccccaggagggttct	5	10	15	11	0	3	0	1	0	2	0	5	1	5	1	3	6	0	2	3	6	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:36499096C>T	uc002hpz.2	-	1	598	c.577G>A	c.(577-579)GAC>AAC	p.D193N		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	193	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GCAGGGGTGTCCAGGTCCCCA	0.637													18	77					0	0	0	0	T	36499096	T	T	36499096	3	4	214	1	0	0	0	0	1	0	0	0	6712	855	30	2	6570	2	GPR179	17	36499096	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3915310	36499096	44696114	519	39409											
PGAP3	93210	broad.mit.edu	37	chr17	37842184	37842184	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctccaactcaccttgccatgGaactgaggcactttgtgacc	9	10	8	14	0	1	2	1	2	0	0	2	3	2	3	4	2	3	1	4	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:37842184G>A	uc002hsj.2	-	2	313	c.270C>T	c.(268-270)TTC>TTT	p.F90F	ERBB2_uc002hsm.2_5'Flank|ERBB2_uc010cwa.2_5'Flank|PGAP3_uc010cvy.2_5'Flank|PGAP3_uc010wej.1_Silent_p.F90F|PGAP3_uc002hsk.2_Silent_p.F90F|PGAP3_uc010cvz.2_Silent_p.F90F|ERBB2_uc002hsl.2_5'Flank	NM_033419	NP_219487	Q96FM1	PGAP3_HUMAN	per1-like domain containing 1 precursor	90	Lumenal (Potential).				GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			upper_aerodigestive_tract(1)	1						CCTTGCCATGGAACTGAGGCA	0.537													6	32					0	0	0	0	A	37842184	A	A	37842184	2	1	214	1	0	0	0	0	0	0	0	1	11834	1165	41	2		2	PGAP3	17	37842184	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1343088	37842184	43353026	520	39410											
WNK4	65266	broad.mit.edu	37	chr17	40936541	40936541	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctggagatggccacctctGagtacccgtactccgagtgc	7	9	12	13	2	1	2	0	1	1	1	2	4	2	2	4	2	4	3	4	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:40936541G>C	uc002ibj.2	+	4	1135	c.1114G>C	c.(1114-1116)GAG>CAG	p.E372Q	WNK4_uc010wgx.1_Silent_p.L65L|WNK4_uc002ibk.1_Missense_Mutation_p.E144Q|WNK4_uc010wgy.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	372	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GGCCACCTCTGAGTACCCGTA	0.597													6	36					0	0	0	0	C	40936541	C	C	40936541	3	2	214	1	0	0	0	0	1	0	0	0	17448	1291	45	2	1128	2	WNK4	17	40936541	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3094357	40936541	40258669	521	39411											
HOXB7	3217	broad.mit.edu	37	chr17	46685395	46685395	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagcgattgtagtgaaattCtttctccagctccagggtct	8	14	10	9	1	3	1	0	1	3	0	5	2	4	1	2	1	2	3	2	1	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:46685395C>A	uc002inv.2	-	2	566	c.463G>T	c.(463-465)GAA>TAA	p.E155*		NM_004502	NP_004493	P09629	HXB7_HUMAN	homeobox B7	155	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TAGTGAAATTCTTTCTCCAGC	0.542													29	90					7.26314e-15	7.89691e-15	1	0	A	46685395	A	A	46685395	4	1	214	1	0	0	0	0	0	1	0	0	7345	922	32	2	194	2	HOXB7	17	46685395	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5748854	46685395	34509815	522	39412											
CACNA1G	8913	broad.mit.edu	37	chr17	48683370	48683370	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccggcacaagtacaactttGacaaccttggccaggtgagc	11	8	10	12	1	0	2	0	2	0	0	1	2	1	2	3	3	4	2	3	3	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:48683370G>C	uc002irk.1	+	23	4780	c.4408G>C	c.(4408-4410)GAC>CAC	p.D1470H	CACNA1G_uc002iri.1_Missense_Mutation_p.D1470H|CACNA1G_uc002irj.1_Missense_Mutation_p.D1447H|CACNA1G_uc002irl.1_Missense_Mutation_p.D1447H|CACNA1G_uc002irm.1_Missense_Mutation_p.D1447H|CACNA1G_uc002irn.1_Missense_Mutation_p.D1447H|CACNA1G_uc002iro.1_Missense_Mutation_p.D1447H|CACNA1G_uc002irp.1_Missense_Mutation_p.D1470H|CACNA1G_uc002irq.1_Missense_Mutation_p.D1447H|CACNA1G_uc002irr.1_Missense_Mutation_p.D1470H|CACNA1G_uc002irs.1_Missense_Mutation_p.D1470H|CACNA1G_uc002irt.1_Missense_Mutation_p.D1470H|CACNA1G_uc002irv.1_Missense_Mutation_p.D1470H|CACNA1G_uc002irw.1_Missense_Mutation_p.D1447H|CACNA1G_uc002iru.1_Missense_Mutation_p.D1447H|CACNA1G_uc002irx.1_Missense_Mutation_p.D1383H|CACNA1G_uc002iry.1_Missense_Mutation_p.D1383H|CACNA1G_uc002irz.1_Missense_Mutation_p.D1383H|CACNA1G_uc002isa.1_Missense_Mutation_p.D1383H|CACNA1G_uc002isb.1_Missense_Mutation_p.D1383H|CACNA1G_uc002isc.1_Missense_Mutation_p.D1383H|CACNA1G_uc002isd.1_Missense_Mutation_p.D1383H|CACNA1G_uc002ise.1_Missense_Mutation_p.D1383H|CACNA1G_uc002isf.1_Missense_Mutation_p.D1383H|CACNA1G_uc002isg.1_Missense_Mutation_p.D1383H|CACNA1G_uc002ish.1_Missense_Mutation_p.D1383H|CACNA1G_uc002isi.1_Missense_Mutation_p.D1360H|CACNA1G_uc002isj.2_Missense_Mutation_p.D194H	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1470	Extracellular (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GTACAACTTTGACAACCTTGG	0.587													21	61					0	0	0	0	C	48683370	C	C	48683370	3	2	214	1	0	0	0	0	1	0	0	0	2556	1290	45	2	4498	2	CACNA1G	17	48683370	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1997975	48683370	32511840	523	39413											
CACNA1G	8913	broad.mit.edu	37	chr17	48684289	48684289	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtccctgttcgttttggcctCcaaggatggttgggtggaca	5	13	14	9	1	0	0	0	0	0	0	3	2	2	2	3	5	0	3	3	5	1	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:48684289C>G	uc002irk.1	+	24	4823	c.4451C>G	c.(4450-4452)TCC>TGC	p.S1484C	CACNA1G_uc002irj.1_Missense_Mutation_p.S1461C|CACNA1G_uc002irl.1_Missense_Mutation_p.S1461C|CACNA1G_uc002irm.1_Missense_Mutation_p.S1461C|CACNA1G_uc002irn.1_Missense_Mutation_p.S1461C|CACNA1G_uc002iro.1_Missense_Mutation_p.S1461C|CACNA1G_uc002irp.1_Missense_Mutation_p.S1484C|CACNA1G_uc002irq.1_Missense_Mutation_p.S1461C|CACNA1G_uc002irr.1_Missense_Mutation_p.S1484C|CACNA1G_uc002irs.1_Missense_Mutation_p.S1484C|CACNA1G_uc002irt.1_Missense_Mutation_p.S1484C|CACNA1G_uc002irv.1_Missense_Mutation_p.S1484C|CACNA1G_uc002irw.1_Missense_Mutation_p.S1461C|CACNA1G_uc002iru.1_Missense_Mutation_p.S1461C|CACNA1G_uc002irx.1_Missense_Mutation_p.S1397C|CACNA1G_uc002iry.1_Missense_Mutation_p.S1397C|CACNA1G_uc002irz.1_Missense_Mutation_p.S1397C|CACNA1G_uc002isa.1_Missense_Mutation_p.S1397C|CACNA1G_uc002isb.1_Missense_Mutation_p.S1397C|CACNA1G_uc002isc.1_Missense_Mutation_p.S1397C|CACNA1G_uc002isd.1_Missense_Mutation_p.S1397C|CACNA1G_uc002ise.1_Missense_Mutation_p.S1397C|CACNA1G_uc002isf.1_Missense_Mutation_p.S1397C|CACNA1G_uc002isg.1_Missense_Mutation_p.S1397C|CACNA1G_uc002ish.1_Missense_Mutation_p.S1397C|CACNA1G_uc002isi.1_Missense_Mutation_p.S1374C|CACNA1G_uc002isj.2_Missense_Mutation_p.S208C	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1484	Extracellular (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GTTTTGGCCTCCAAGGATGGT	0.577													16	41					0	0	0	0	G	48684289	G	G	48684289	3	3	214	1	0	0	0	0	1	0	0	0	2556	855	30	2	4791	2	CACNA1G	17	48684289	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	919	48684289	32510921	524	39414											
C17orf67	339210	broad.mit.edu	37	chr17	54893308	54893308	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtatgatgctgaatgtatctGactctgagcgttttagtaat	10	16	10	5	1	2	4	0	4	2	0	2	4	2	4	0	0	2	5	0	0	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:54893308G>A	uc010dci.2	-						C17orf67_uc002iuq.2_RNA	NM_001085430	NP_001078899	Q0P5P2	CQ067_HUMAN	hypothetical protein LOC339210 precursor							extracellular region					0	Breast(9;2.49e-06)					GAATGTATCTGACTCTGAGCG	0.433													6	29					0	0	0	0	A	54893308	A	A	54893308	1	1	214	0	1	0	0	0	0	0	0	0	1882	1305	45	2		2	C17orf67	17	54893308	5'Flank	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6209019	54893308	26301902	525	39415											
OR4D2	124538	broad.mit.edu	37	chr17	56247319	56247319	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagggctgcatgggtcagatCttcttcttccactttttggg	5	15	11	10	0	4	1	1	0	3	1	5	1	5	1	1	3	1	2	1	3	0	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:56247319C>G	uc010wnp.1	+	1	303	c.303C>G	c.(301-303)ATC>ATG	p.I101M		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	101	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TGGGTCAGATCTTCTTCTTCC	0.527													10	121					0	0	0	0	G	56247319	G	G	56247319	3	3	214	1	0	0	0	0	1	0	0	0	11110	903	32	2	305	2	OR4D2	17	56247319	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1354011	56247319	24947891	526	39416											
CACNG4	27092	broad.mit.edu	37	chr17	65026887	65026887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtccagctcaaggtccaccGaggcctcgccctccagggac	7	5	12	17	2	1	0	1	0	0	0	5	2	4	1	6	4	1	1	6	4	1	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:65026887G>A	uc002jft.1	+	4	766	c.751G>A	c.(751-753)GAG>AAG	p.E251K		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	251	Cytoplasmic (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			AAGGTCCACCGAGGCCTCGCC	0.632													24	58					0	0	0	0	A	65026887	A	A	65026887	3	1	214	1	0	0	0	0	1	0	0	0	2571	1059	37	1	765	1	CACNG4	17	65026887	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	8779568	65026887	16168323	527	39417											
FAM20A	54757	broad.mit.edu	37	chr17	66548055	66548055	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcccgaaatccgagaacctCagcaccagcttgaggtggac	11	7	10	13	2	1	2	1	1	0	1	3	5	3	3	4	2	3	2	4	2	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:66548055C>T	uc002jho.2	-	4	966	c.678G>A	c.(676-678)CTG>CTA	p.L226L	FAM20A_uc010wqp.1_Silent_p.L88L|FAM20A_uc002jhn.2_5'UTR	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	226						extracellular region					0	Breast(10;1.64e-13)					CCGAGAACCTCAGCACCAGCT	0.552													3	3					0	0	0	0	T	66548055	T	T	66548055	2	4	214	1	0	0	0	0	0	0	0	1	5565	813	29	2		2	FAM20A	17	66548055	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1521168	66548055	14647155	528	39418											
EVPL	2125	broad.mit.edu	37	chr17	74018542	74018542	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccataggcgtcgatctccttCtgcaggatgttgtgctcggc	5	12	12	12	3	2	0	0	0	2	0	5	2	2	1	2	3	2	3	2	3	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:74018542C>T	uc002jqi.2	-	5	786	c.558G>A	c.(556-558)CAG>CAA	p.Q186Q	EVPL_uc010wss.1_Silent_p.Q186Q|EVPL_uc010wst.1_5'UTR	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	186	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						CGATCTCCTTCTGCAGGATGT	0.672													3	44					0	0	0	0	T	74018542	T	T	74018542	2	4	214	1	0	0	0	0	0	0	0	1	5316	912	32	2		2	EVPL	17	74018542	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	7470487	74018542	7176668	529	39419											
DNAH17	8632	broad.mit.edu	37	chr17	76455098	76455098	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttacggcaatcttgtttttGatccgggacagcttctcttg	6	16	9	10	2	2	1	0	1	2	0	4	2	3	2	1	2	2	3	1	2	2	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:76455098G>A	uc010dhp.1	-	6	1068	c.846C>T	c.(844-846)ATC>ATT	p.I282I	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCTTGTTTTTGATCCGGGACA	0.582													21	61					0	0	0	0	A	76455098	A	A	76455098	2	1	214	1	0	0	0	0	0	0	0	1	4623	1280	45	2		2	DNAH17	17	76455098	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2436556	76455098	4740112	530	39420											
DNAH17	8632	broad.mit.edu	37	chr17	76455962	76455962	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccatcatgatcttggccGccttccagctcttgtccttg	4	14	8	15	1	3	1	1	1	2	0	5	1	5	1	5	1	2	1	5	1	0	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:76455962G>A	uc010dhp.1	-	5	779	c.557C>T	c.(556-558)GCG>GTG	p.A186V	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GATCTTGGCCGCCTTCCAGCT	0.592													41	34					0	0	0	0	A	76455962	A	A	76455962	3	1	214	1	0	0	0	0	1	0	0	0	4623	1087	38	1	3919	1	DNAH17	17	76455962	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	864	76455962	4739248	531	39421											
RNF213	57674	broad.mit.edu	37	chr17	78358943	78358943	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagttgaatacagctccatCagaggcttcctcagcaagca	13	8	8	12	0	2	2	2	1	0	1	4	2	4	2	2	1	4	5	2	1	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:78358943C>T	uc002jyh.1	+	35	8869	c.8646C>T	c.(8644-8646)ATC>ATT	p.I2882I	uc002jyi.1_Intron|RNF213_uc010dhx.1_5'Flank	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ACAGCTCCATCAGAGGCTTCC	0.532													11	44					0	0	0	0	T	78358943	T	T	78358943	2	4	214	1	0	0	0	0	0	0	0	1	13542	816	29	2		2	RNF213	17	78358943	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1902981	78358943	2836267	532	39422											
NPLOC4	55666	broad.mit.edu	37	chr17	79563226	79563226	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggatgcttgttctggaagtCtcctgcagtgatgcactctt	6	14	12	9	0	3	1	0	1	3	0	4	3	3	3	1	2	3	4	1	2	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:79563226C>G	uc002kat.3	-	11	1218	c.1036G>C	c.(1036-1038)GAC>CAC	p.D346H	NPLOC4_uc002kau.3_Missense_Mutation_p.D346H|NPLOC4_uc010wur.1_Missense_Mutation_p.D185H	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	346					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TTCTGGAAGTCTCCTGCAGTG	0.443													24	59					0	0	0	0	G	79563226	G	G	79563226	3	3	214	1	0	0	0	0	1	0	0	0	10640	913	32	2	818	2	NPLOC4	17	79563226	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1204283	79563226	1631984	533	39423											
P4HB	5034	broad.mit.edu	37	chr17	79813047	79813047	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaggacaaccccatctttgtCgagctggtatttggagaaca	11	10	11	9	1	1	1	0	0	1	1	2	5	1	2	2	3	3	2	2	3	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:79813047C>G	uc002kbn.1	-	4	792	c.595G>C	c.(595-597)GAC>CAC	p.D199H	P4HB_uc002kbm.1_5'UTR	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	199					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			CCATCTTTGTCGAGCTGGTAT	0.542													65	197					0	0	0	0	G	79813047	G	G	79813047	3	3	214	1	0	0	0	0	1	0	0	0	11413	884	31	3	963	3	P4HB	17	79813047	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	249821	79813047	1382163	534	39424											
NOTUM	147111	broad.mit.edu	37	chr17	79916266	79916266	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcactggagcagtaggggatGaagctgcaacacagaacaga	15	5	13	8	0	1	3	1	1	0	2	1	5	1	5	0	3	5	4	0	3	4	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:79916266G>A	uc010wvg.1	-	5	809	c.537C>T	c.(535-537)TTC>TTT	p.F179F		NM_178493	NP_848588	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog precursor	179						extracellular region	hydrolase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			AGTAGGGGATGAAGCTGCAAC	0.502													11	44					0	0	0	0	A	79916266	A	A	79916266	2	1	214	1	0	0	0	0	0	0	0	1	10606	1281	45	2		2	NOTUM	17	79916266	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	103219	79916266	1278944	535	39425											
FASN	2194	broad.mit.edu	37	chr17	80044282	80044282	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgccagctccagctgcaGgttcccgttgagctgaagcc	6	8	12	15	2	0	2	0	2	0	0	2	2	2	2	4	1	6	6	4	1	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:80044282G>C	uc002kdu.2	-	22	3697	c.3580C>G	c.(3580-3582)CTG>GTG	p.L1194V	FASN_uc002kdw.1_Missense_Mutation_p.L410V	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	1194					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	TCCAGCTGCAGGTTCCCGTTG	0.697													12	27					0	0	0	0	C	80044282	C	C	80044282	3	2	214	1	0	0	0	0	1	0	0	0	5715	991	35	4	4043	4	FASN	17	80044282	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	128016	80044282	1150928	536	39426											
C17orf62	79415	broad.mit.edu	37	chr17	80405459	80405459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggggggtgctttacctcCgctgtagtaggcagcagcca	6	8	16	11	2	0	0	0	0	0	0	1	0	1	0	3	5	4	6	3	5	3	4	rs142773924		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:80405459C>T	uc002kez.2	-	2	172	c.124G>A	c.(124-126)GGA>AGA	p.G42R	C17orf62_uc002kex.2_5'Flank|C17orf62_uc002key.2_5'UTR|C17orf62_uc002kfa.2_Missense_Mutation_p.G42R|C17orf62_uc010dir.2_Missense_Mutation_p.G42R|C17orf62_uc002kfb.3_Missense_Mutation_p.G42R|C17orf62_uc002kfc.3_Intron|C17orf62_uc002kfd.3_5'UTR|C17orf62_uc002kfe.3_Intron|C17orf62_uc010dis.1_Missense_Mutation_p.G42R	NM_001100407	NP_001093877	Q9BQA9	CQ062_HUMAN	hypothetical protein LOC79415 isoform a	42	Helical; (Potential).					integral to membrane	protein binding				0	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			GCTTTACCTCCGCTGTAGTAG	0.542													4	14					0	0	0	0	T	80405459	T	T	80405459	3	4	214	1	0	0	0	0	1	0	0	0	1877	661	23	1	459	1	C17orf62	17	80405459	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	361177	80405459	789751	537	39427											
ZNF750	79755	broad.mit.edu	37	chr17	80790179	80790179	+	Frame_Shift_Del	DEL	T	-	-																															ctgatactaaagtaatcgagTttttacaaagaccatacttc																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr17:80790179delT	uc002kga.2	-	2	463	c.152delA	c.(151-153)AACfs	p.N51fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	51						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGTAATCGAGTTTTTACAAAG	0.433													---	---	---								-	80790179	-	-	80790179	7	5	214	1	0	1	0	1	0	0	0	0	18199	1725	60	0	2027	0	ZNF750	17	80790179	Frame_Shift_Del	DEL	T	TCGA-CV-6961-01A-21D-1912-08	384720	80790179	405031	538	39428											
IMPA2	3613	broad.mit.edu	37	chr18	12028874	12028874	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagctccacattggcactCtgccacctggcctcaggggc	7	7	12	15	0	2	0	1	0	1	0	3	1	3	1	4	5	2	2	4	5	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr18:12028874C>T	uc002kqp.1	+	7	847	c.633C>T	c.(631-633)CTC>CTT	p.L211L	IMPA2_uc002kqo.1_Silent_p.L22L|IMPA2_uc002kqq.1_Silent_p.L91L	NM_014214	NP_055029	O14732	IMPA2_HUMAN	inositol(myo)-1(or 4)-monophosphatase 2	211					inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(2)	2					Lithium(DB01356)	CATTGGCACTCTGCCACCTGG	0.617													42	63					0	0	0	0	T	12028874	T	T	12028874	2	4	214	1	0	0	0	0	0	0	0	1	7762	900	32	2		2	IMPA2	18	12028874	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08		12028874	66048374	539	39429											
MIB1	57534	broad.mit.edu	37	chr18	19429231	19429231	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaagagtgtatggtgtgctCagatatgaagagagatactc	14	10	13	4	0	1	6	1	1	0	5	2	7	1	6	0	1	2	2	0	1	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr18:19429231C>G	uc002ktq.2	+	17	2468	c.2468C>G	c.(2467-2469)TCA>TGA	p.S823*	MIB1_uc002ktp.2_Nonsense_Mutation_p.S462*	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	823	RING-type 1.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			ATGGTGTGCTCAGATATGAAG	0.378													50	127					0	0	0	0	G	19429231	G	G	19429231	4	3	214	1	0	0	0	0	0	1	0	0	9619	838	29	2	2534	2	MIB1	18	19429231	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	7400357	19429231	58648017	540	39430											
GATA6	2627	broad.mit.edu	37	chr18	19761413	19761413	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttcttgtactgtttctaGccttcatcacggcggcttgg	5	16	10	10	2	4	0	2	0	2	0	4	0	4	0	1	3	2	4	1	3	2	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr18:19761413G>A	uc002ktt.1	+	4	1568	c.1303_splice	c.e4-1	p.P435_splice	GATA6_uc002ktu.1_Splice_Site_p.P435_splice	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6						blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			ACTGTTTCTAGCCTTCATCAC	0.418													11	44					0	0	0	0	A	19761413	A	A	19761413	5	1	214	1	0	0	0	0	0	0	1	0	6293	985	34	4	1312	4	GATA6	18	19761413	Splice_Site	SNP	G	TCGA-CV-6961-01A-21D-1912-08	332182	19761413	58315835	541	39431											
LAMA3	3909	broad.mit.edu	37	chr18	21404467	21404467	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccctggaaatggttttgcaGacccattttcaatcacacca	11	12	6	12	0	2	1	2	0	0	1	3	2	3	2	3	2	1	2	3	2	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr18:21404467G>C	uc002kuq.2	+	21	2595	c.2509G>C	c.(2509-2511)GAC>CAC	p.D837H	LAMA3_uc002kur.2_Missense_Mutation_p.D837H	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	837	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGTTTTGCAGACCCATTTTC	0.458													31	75					0	0	0	0	C	21404467	C	C	21404467	3	2	214	1	0	0	0	0	1	0	0	0	8647	942	33	2	2591	2	LAMA3	18	21404467	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1643054	21404467	56672781	542	39432											
DYM	54808	broad.mit.edu	37	chr18	46906126	46906126	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgttcgaggattgttttCaactgcaagagaagaaaagg	13	11	11	6	1	1	2	1	0	0	2	3	5	2	3	1	2	2	3	1	2	5	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr18:46906126C>A	uc002ldi.1	-	4	561	c.196G>T	c.(196-198)GAA>TAA	p.E66*	DYM_uc010xdf.1_Intron	NM_017653	NP_060123	Q7RTS9	DYM_HUMAN	dymeclin	66				E -> K (in Ref. 2; BAC11088).		Golgi apparatus					0						GGATTGTTTTCAACTGCAAGA	0.303													15	42					2.31682e-05	2.40888e-05	1	0	A	46906126	A	A	46906126	4	1	214	1	0	0	0	0	0	1	0	0	4862	835	29	2	1869	2	DYM	18	46906126	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	25501659	46906126	31171122	543	39433											
ZCCHC2	54877	broad.mit.edu	37	chr18	60212054	60212054	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtaaattggtctgatctttCagtcacaacagtaacaaaaa	16	11	7	7	0	4	1	2	1	2	0	4	1	4	1	0	2	2	2	0	2	6	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ea8183de-8f9b-4d30-a23b-c6ffc183f22b	g.chr18:60212054C>G	uc002lip.3	+	4	1148	c.1148C>G	c.(1147-1149)TCA>TGA	p.S383*	ZCCHC2_uc002lio.2_RNA	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	383					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						TCTGATCTTTCAGTCACAACA	0.308													2	2					0	0	0	0	G	60212054	G	G	60212054	4	3	214	1	0	0	0	0	0	1	0	0	17654	838	29	2	1162	2	ZCCHC2	18	60212054	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	13305928	60212054	17865194	544	39434											
RTTN	25914	broad.mit.edu	37	chr18	67801735	67801735	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaacggaaacaggcaaactGaagaccgatggcaaagaagg	20	2	12	7	2	0	3	0	1	0	2	0	5	0	4	1	4	3	2	1	4	7	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr18:67801735G>A	uc002lkp.2	-	23	2996	c.2928C>T	c.(2926-2928)TTC>TTT	p.F976F	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Silent_p.F64F	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	976							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				CAGGCAAACTGAAGACCGATG	0.323													12	28					0	0	0	0	A	67801735	A	A	67801735	2	1	214	1	0	0	0	0	0	0	0	1	13802	1281	45	2		2	RTTN	18	67801735	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	7589681	67801735	10275513	545	39435											
MED16	10025	broad.mit.edu	37	chr19	873569	873569	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgtcttgaggttgatcatGaccttgtcaatgtctacaag	9	14	9	9	1	4	3	2	3	2	0	5	3	5	3	2	1	1	1	2	1	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:873569G>C	uc002lqd.1	-	11	1936	c.1785C>G	c.(1783-1785)GTC>GTG	p.V595V	MED16_uc010drw.1_Silent_p.V420V|MED16_uc002lqe.2_Silent_p.V584V|MED16_uc002lqf.2_Silent_p.V584V|MED16_uc010xfv.1_RNA|MED16_uc010xfw.1_Silent_p.V515V|MED16_uc010xfx.1_Silent_p.V440V|MED16_uc010xfy.1_Silent_p.V172V|MED16_uc010xfz.1_RNA	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	595					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTTGATCATGACCTTGTCAA	0.572													21	33					0	0	0	0	C	873569	C	C	873569	2	2	214	1	0	0	0	0	0	0	0	1	9487	1277	45	2		2	MED16	19	873569	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08		873569	58255414	546	39436											
STK11	6794	broad.mit.edu	37	chr19	1220487	1220487	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggcaccctcaaaatctccGacctgggcgtggccgaggta	8	7	13	13	3	2	0	1	0	1	0	3	2	2	0	4	4	0	2	4	4	3	1	rs121913315		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:1220487G>A	uc002lrl.1	+	4	1695	c.580G>A	c.(580-582)GAC>AAC	p.D194N		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	194	Protein kinase.		D -> V (in lung cancer; somatic mutation).|D -> Y (in melanoma; sporadic malignant; somatic mutation).|D -> N (in PJS).	D->A: Loss of kinase activity.	anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.D194Y(6)|p.Y156fs*87(4)|p.?(3)|p.D194N(3)|p.D194fs*93(1)|p.D194V(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAAATCTCCGACCTGGGCGT	0.677	D194N(ALEXANDERCELLS_LIVER)|D194N(PLCPRF5_LIVER)	14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			4	6					0	0	0	0	A	1220487	A	A	1220487	3	1	214	1	0	0	0	0	1	0	0	0	15353	1058	37	1	594	1	STK11	19	1220487	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	346918	1220487	57908496	547	39437											
STK11	6794	broad.mit.edu	37	chr19	1221270	1221270	+	Frame_Shift_Del	DEL	G	-	-																															acaacatctacaagttgtttGagaacatcgggaaggggagc																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:1221270delG	uc002lrl.1	+	6	1908	c.793delG	c.(793-795)GAGfs	p.E265fs		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	265	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(2)|p.Y246fs*3(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAGTTGTTTGAGAACATCGG	0.597		14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			---	---	---								-	1221270	-	-	1221270	7	5	214	1	0	1	0	1	0	0	0	0	15353	1291	45	0	815	0	STK11	19	1221270	Frame_Shift_Del	DEL	G	TCGA-CV-6961-01A-21D-1912-08	783	1221270	57907713	548	39438	78	2									
STK11	6794	broad.mit.edu	37	chr19	1221279	1221279	+	Missense_Mutation	SNP	G	A	A																															acaagttgtttgagaacatcGggaaggggagctacgccatc																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:1221279G>A	uc002lrl.1	+	6	1917	c.802G>A	c.(802-804)GGG>AGG	p.G268R		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	268	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(2)|p.Y246fs*3(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAGAACATCGGGAAGGGGAG	0.607		14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			5	8					0	0	0	0	A	1221279	A	A	1221279	3	1	214	1	0	0	0	0	1	0	0	0	15353	1116	39	1	824	1	STK11	19	1221279	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9	1221279	57907704	549	39439	78	2									
MBD3	53615	broad.mit.edu	37	chr19	1585105	1585105	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgctggcggctcttgttcatCttgctcatcagcatcttgcc	4	14	9	14	2	6	0	3	0	3	0	6	0	6	0	1	2	3	5	1	2	0	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:1585105C>T	uc002ltl.1	-	2	241	c.219G>A	c.(217-219)AAG>AAA	p.K73K	MBD3_uc002ltj.2_Silent_p.K73K|MBD3_uc002ltk.2_Silent_p.K41K	NM_003926	NP_003917	O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	73					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			ovary(1)|pancreas(1)|skin(1)	3		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTTGTTCATCTTGCTCATCA	0.647													6	25					0	0	0	0	T	1585105	T	T	1585105	2	4	214	1	0	0	0	0	0	0	0	1	9397	912	32	2		2	MBD3	19	1585105	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	363826	1585105	57543878	550	39440											
MUC16	94025	broad.mit.edu	37	chr19	9000195	9000195	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acagagggccaacactggtgTtcttgaacacaggcctgagc	11	7	12	11	0	1	3	0	2	1	1	1	3	1	3	2	3	3	1	2	3	2	2	rs150399289	by1000genomes	TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:9000195T>C	uc002mkp.2	-	55	40766	c.40562A>G	c.(40561-40563)AAC>AGC	p.N13521S	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.N338S|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13523	SEA 10.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AACACTGGTGTTCTTGAACAC	0.567													30	39					0	0	0	0	C	9000195	C	C	9000195	3	2	214	1	0	0	0	0	1	0	0	0	10026	1725	60	5	3081	5	MUC16	19	9000195	Missense_Mutation	SNP	T	TCGA-CV-6961-01A-21D-1912-08	7415090	9000195	50128788	551	39441											
MUC16	94025	broad.mit.edu	37	chr19	9011341	9011341	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccattgacatagagactgttCctgtccagggtgtaggggcc	8	10	13	10	0	0	2	0	1	0	1	2	3	2	2	4	3	0	2	4	3	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:9011341C>T	uc002mkp.2	-	36	39096	c.38892G>A	c.(38890-38892)AGG>AGA	p.R12964R	MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12966	SEA 6.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGAGACTGTTCCTGTCCAGGG	0.547													49	150					0	0	0	0	T	9011341	T	T	9011341	2	4	214	1	0	0	0	0	0	0	0	1	10026	854	30	2		2	MUC16	19	9011341	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	11146	9011341	50117642	552	39442											
MUC16	94025	broad.mit.edu	37	chr19	9047213	9047213	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgtcagtgttgggaaagttGtagtgctgtctgtcccagaa	8	12	13	8	1	2	1	1	0	1	1	3	2	3	2	2	1	1	4	2	1	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:9047213G>A	uc002mkp.2	-	5	34622	c.34418C>T	c.(34417-34419)ACA>ATA	p.T11473I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11475	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGGAAAGTTGTAGTGCTGTC	0.507													30	57					0	0	0	0	A	9047213	A	A	9047213	3	1	214	1	0	0	0	0	1	0	0	0	10026	1377	48	4	9425	4	MUC16	19	9047213	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	35872	9047213	50081770	553	39443											
SPC24	147841	broad.mit.edu	37	chr19	11266370	11266370	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgtggcgccccagcagccgtCgctgctgcgcctccgcgcgg	2	5	15	19	8	0	0	0	0	0	0	2	0	1	0	5	2	4	3	5	2	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:11266370C>G	uc002mql.2	-	1	115	c.83G>C	c.(82-84)CGA>CCA	p.R28P	SPC24_uc010xlp.1_Missense_Mutation_p.R28P	NM_182513	NP_872319	Q8NBT2	SPC24_HUMAN	spindle pole body component 24 homolog	28	Interaction with the NDC80-CDCA1 subcomplex.|Interaction with the N-terminus of SPBC25.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding				0						CAGCAGCCGTCGCTGCTGCGC	0.701													3	10					0	0	0	0	G	11266370	G	G	11266370	3	3	214	1	0	0	0	0	1	0	0	0	15087	884	31	3	530	3	SPC24	19	11266370	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2219157	11266370	47862613	554	39444											
ZNF700	90592	broad.mit.edu	37	chr19	12060474	12060474	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccaatgtggtaaagccttCagatgttgcaattcccttcg	11	12	8	10	1	1	1	1	0	0	1	3	1	2	1	3	1	3	3	3	1	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:12060474C>T	uc002msu.2	+	4	1761	c.1635C>T	c.(1633-1635)TTC>TTT	p.F545F	ZNF700_uc010xme.1_Silent_p.F563F|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	545	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTAAAGCCTTCAGATGTTGCA	0.423													17	61					0	0	0	0	T	12060474	T	T	12060474	2	4	214	1	0	0	0	0	0	0	0	1	18171	825	29	2		2	ZNF700	19	12060474	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	794104	12060474	47068509	555	39445											
NACC1	112939	broad.mit.edu	37	chr19	13247198	13247198	+	Nonsense_Mutation	SNP	G	T	T																															acgacgagggcgacccctctGagaagctggagctggtgaca																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:13247198G>T	uc002mwm.2	+	3	1267	c.1099G>T	c.(1099-1101)GAG>TAG	p.E367*		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	367					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						CGACCCCTCTGAGAAGCTGGA	0.612													14	51					4.14922e-12	4.48024e-12	1	0	T	13247198	T	T	13247198	4	4	214	1	0	0	0	0	0	1	0	0	10188	1291	45	2	1105	2	NACC1	19	13247198	Nonsense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1186724	13247198	45881785	556	39446	79	2									
NACC1	112939	broad.mit.edu	37	chr19	13247207	13247207	+	Missense_Mutation	SNP	G	C	C																															gcgacccctctgagaagctgGagctggtgacaggtgggccg																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:13247207G>C	uc002mwm.2	+	3	1276	c.1108G>C	c.(1108-1110)GAG>CAG	p.E370Q		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	370					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						TGAGAAGCTGGAGCTGGTGAC	0.582													12	46					0	0	0	0	C	13247207	C	C	13247207	3	2	214	1	0	0	0	0	1	0	0	0	10188	1175	41	2	1114	2	NACC1	19	13247207	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	9	13247207	45881776	557	39447	79	2									
C19orf57	79173	broad.mit.edu	37	chr19	14000824	14000824	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagggcctgaggtaggagctGatgctggggtacaggggaca	9	6	19	7	0	0	2	0	2	0	0	0	4	0	4	1	7	3	4	1	7	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:14000824G>C	uc002mxl.1	-	6	904	c.845C>G	c.(844-846)TCA>TGA	p.S282*	C19orf57_uc002mxk.1_Nonsense_Mutation_p.S164*|C19orf57_uc002mxm.1_Intron	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	282					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GGTAGGAGCTGATGCTGGGGT	0.711													6	42					0	0	0	0	C	14000824	C	C	14000824	4	2	214	1	0	0	0	0	0	1	0	0	1948	1294	45	2	1080	2	C19orf57	19	14000824	Nonsense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	753617	14000824	45128159	558	39448											
CC2D1A	54862	broad.mit.edu	37	chr19	14020719	14020719	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagaactggaggctgagttCttggctttggtcgggggcca	7	10	17	7	1	1	2	0	1	1	1	2	4	1	3	1	6	1	3	1	6	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:14020719C>T	uc002mxo.2	+	2	443	c.144C>T	c.(142-144)TTC>TTT	p.F48F	CC2D1A_uc002mxn.2_Missense_Mutation_p.S8F|CC2D1A_uc002mxp.2_Silent_p.F48F	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	48					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			AGGCTGAGTTCTTGGCTTTGG	0.522													20	67					0	0	0	0	T	14020719	T	T	14020719	2	4	214	1	0	0	0	0	0	0	0	1	2738	912	32	2		2	CC2D1A	19	14020719	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	19895	14020719	45108264	559	39449											
SYDE1	85360	broad.mit.edu	37	chr19	15222217	15222217	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcagcggtctgcctatctGaggacctgtaccccgatatc	7	10	11	13	2	2	1	0	1	2	0	3	3	2	2	4	2	4	2	4	2	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:15222217G>A	uc002nah.1	+	5	1415	c.1384G>A	c.(1384-1386)GAG>AAG	p.E462K	SYDE1_uc002nai.1_Missense_Mutation_p.E395K|SYDE1_uc002naj.1_Missense_Mutation_p.E119K	NM_033025	NP_149014	Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1	462	Rho-GAP.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|pancreas(1)	2						CTGCCTATCTGAGGACCTGTA	0.592													4	56					0	0	0	0	A	15222217	A	A	15222217	3	1	214	1	0	0	0	0	1	0	0	0	15501	1291	45	2	1402	2	SYDE1	19	15222217	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1201498	15222217	43906766	560	39450											
SSBP4	170463	broad.mit.edu	37	chr19	18543509	18543509	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacagctgcccttgtccccaGatcccctactcctcctcatc	6	10	4	21	0	1	1	1	0	0	1	6	1	5	1	7	0	3	1	7	0	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:18543509G>C	uc002niy.2	+	12	989	c.751_splice	c.e12-1	p.I251_splice	SSBP4_uc002niz.2_Splice_Site_p.I229_splice	NM_032627	NP_116016	Q9BWG4	SSBP4_HUMAN	single stranded DNA binding protein 4 isoform a							nucleus	single-stranded DNA binding				0						CTTGTCCCCAGATCCCCTACT	0.647													11	22					0	0	0	0	C	18543509	C	C	18543509	5	2	214	1	0	0	0	0	0	0	1	0	15248	956	33	2	796	2	SSBP4	19	18543509	Splice_Site	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3321292	18543509	40585474	561	39451											
TSSK6	83983	broad.mit.edu	37	chr19	19625897	19625897	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcgatctgcgcaaagaggtCgcgcgcctgaactccgggga	8	5	16	12	6	1	2	0	1	1	1	3	4	2	3	2	4	2	1	2	4	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:19625897C>T	uc002nmr.2	-	1	573	c.340G>A	c.(340-342)GAC>AAC	p.D114N	TSSK6_uc002nmq.2_RNA|NDUFA13_uc002nms.2_5'Flank|NDUFA13_uc010xqx.1_5'Flank|NDUFA13_uc010xqy.1_5'Flank	NM_032037	NP_114426	Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6	114	Protein kinase.				multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1						GCAAAGAGGTCGCGCGCCTGA	0.657													22	53					0	0	0	0	T	19625897	T	T	19625897	3	4	214	1	0	0	0	0	1	0	0	0	16739	884	31	1	485	1	TSSK6	19	19625897	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1082388	19625897	39503086	562	39452											
NUDT19	390916	broad.mit.edu	37	chr19	33183199	33183199	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccgacaccgatgaccacaaGaccgacaacactgggacgct	13	3	9	16	4	0	2	0	1	0	1	0	6	0	3	4	1	1	1	4	1	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:33183199G>A	uc010edf.2	+	1	333	c.333G>A	c.(331-333)AAG>AAA	p.K111K		NM_001105570	NP_001099040	A8MXV4	NUD19_HUMAN	nudix (nucleoside diphosphate linked moiety	111	Nudix hydrolase.					mitochondrion|peroxisome	hydrolase activity|metal ion binding				0	Esophageal squamous(110;0.137)					ATGACCACAAGACCGACAACA	0.716													13	27					0	0	0	0	A	33183199	A	A	33183199	2	1	214	1	0	0	0	0	0	0	0	1	10790	933	33	2		2	NUDT19	19	33183199	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	13557302	33183199	25945784	563	39453											
GRAMD1A	57655	broad.mit.edu	37	chr19	35502416	35502416	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggcccgtgaccgctgcttCctcctcatcttccgcctctg	2	11	10	18	3	3	1	1	1	2	0	6	1	6	1	6	2	1	2	6	2	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:35502416C>T	uc010xse.1	+	7	701	c.564C>T	c.(562-564)TTC>TTT	p.F188F	GRAMD1A_uc002nxi.1_Silent_p.F275F|GRAMD1A_uc002nxk.2_Silent_p.F181F|GRAMD1A_uc002nxl.2_5'UTR|GRAMD1A_uc010xsf.1_Silent_p.F193F|GRAMD1A_uc002nxm.1_5'Flank	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	188						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ACCGCTGCTTCCTCCTCATCT	0.617													11	129					0	0	0	0	T	35502416	T	T	35502416	2	4	214	1	0	0	0	0	0	0	0	1	6786	854	30	2		2	GRAMD1A	19	35502416	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2319217	35502416	23626567	564	39454											
USF2	7392	broad.mit.edu	37	chr19	35761375	35761375	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatccaaaatcccttcagcaAtggtggcagtccggcggccg	9	7	12	13	3	1	0	1	0	0	0	4	1	4	0	4	4	1	2	4	4	3	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:35761375A>G	uc002nyq.1	+	5	564	c.455A>G	c.(454-456)AAT>AGT	p.N152S	USF2_uc010xss.1_Missense_Mutation_p.N152S|USF2_uc002nyr.1_Missense_Mutation_p.N85S|USF2_uc002nys.1_5'UTR|USF2_uc002nyt.1_Intron|USF2_uc002nyu.1_5'UTR|USF2_uc002nyv.1_5'UTR	NM_003367	NP_003358	Q15853	USF2_HUMAN	upstream stimulatory factor 2 isoform 1	152					lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by glucose	nucleus	bHLH transcription factor binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity				0	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCCTTCAGCAATGGTGGCAGT	0.592													23	53					0	0	0	0	G	35761375	G	G	35761375	3	3	214	1	0	0	0	0	1	0	0	0	17101	101	4	5	473	5	USF2	19	35761375	Missense_Mutation	SNP	A	TCGA-CV-6961-01A-21D-1912-08	258959	35761375	23367608	565	39455											
TMEM147	10430	broad.mit.edu	37	chr19	36037925	36037925	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagcatagactccaacatCagtctggtaggcagtcgtgc	11	9	11	10	1	2	2	1	1	1	1	4	2	3	2	1	2	3	3	1	2	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:36037925C>T	uc002oaj.1	+	5	520	c.423C>T	c.(421-423)ATC>ATT	p.I141I	uc010eec.1_5'Flank|uc002oag.2_5'Flank|TMEM147_uc002oai.1_Silent_p.I92I|TMEM147_uc002oak.1_Silent_p.I96I	NM_032635	NP_116024	Q9BVK8	TM147_HUMAN	transmembrane protein 147	141	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			ACTCCAACATCAGTCTGGTAG	0.567													19	93					0	0	0	0	T	36037925	T	T	36037925	2	4	214	1	0	0	0	0	0	0	0	1	16127	816	29	2		2	TMEM147	19	36037925	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	276550	36037925	23091058	566	39456											
ZNF383	163087	broad.mit.edu	37	chr19	37726940	37726940	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaagggaaagagccctggAtggttggcagagagcttaca	14	6	14	7	0	0	2	0	0	0	2	0	5	0	4	1	4	4	3	1	4	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:37726940A>G	uc002oft.1	+	7	776	c.196A>G	c.(196-198)ATG>GTG	p.M66V	ZNF383_uc002ofs.1_Missense_Mutation_p.M1V|ZNF383_uc002ofu.1_Missense_Mutation_p.M66V	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	66	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.M66I(1)		ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGAGCCCTGGATGGTTGGCAG	0.498													26	71					0	0	0	0	G	37726940	G	G	37726940	3	3	214	1	0	0	0	0	1	0	0	0	17941	333	12	5	206	5	ZNF383	19	37726940	Missense_Mutation	SNP	A	TCGA-CV-6961-01A-21D-1912-08	1689015	37726940	21402043	567	39457											
MAP4K1	11184	broad.mit.edu	37	chr19	39101700	39101700	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggagggttacactgagcatCttggtggcgctgggtcgttt	5	12	17	7	2	1	1	0	1	1	0	2	2	1	2	0	5	2	4	0	5	1	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:39101700C>G	uc002oix.1	-	11	909	c.801G>C	c.(799-801)AAG>AAC	p.K267N	MAP4K1_uc002oiy.1_Missense_Mutation_p.K267N|MAP4K1_uc010xug.1_Intron	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	267	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CACTGAGCATCTTGGTGGCGC	0.532													6	16					0	0	0	0	G	39101700	G	G	39101700	3	3	214	1	0	0	0	0	1	0	0	0	9312	912	32	2	1850	2	MAP4K1	19	39101700	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1374760	39101700	20027283	568	39458											
MAP4K1	11184	broad.mit.edu	37	chr19	39103253	39103253	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccccacgcctgcctacctGagagggtgcacatcaaagag	11	5	11	14	1	1	2	1	1	0	2	1	4	1	2	5	1	3	1	5	1	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:39103253G>A	uc002oix.1	-	9	771	c.663C>T	c.(661-663)CTC>CTT	p.L221L	MAP4K1_uc002oiy.1_Silent_p.L221L|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	221	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTGCCTACCTGAGAGGGTGCA	0.607													13	23					0	0	0	0	A	39103253	A	A	39103253	2	1	214	1	0	0	0	0	0	0	0	1	9312	1277	45	2		2	MAP4K1	19	39103253	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1553	39103253	20025730	569	39459											
LRFN1	57622	broad.mit.edu	37	chr19	39798557	39798557	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gggcgccgaggttggtggctCcagggcgccggatcggctcc	3	6	19	13	5	0	0	0	0	0	0	3	2	2	1	4	7	0	3	4	7	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ea8183de-8f9b-4d30-a23b-c6ffc183f22b	g.chr19:39798557C>G	uc002okw.2	-	2	2032	c.2032G>C	c.(2032-2034)GAG>CAG	p.E678Q		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	678	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GTTGGTGGCTCCAGGGCGCCG	0.716													3	8					0	0	0	0	G	39798557	G	G	39798557	3	3	214	1	0	0	0	0	1	0	0	0	8987	864	30	2	287	2	LRFN1	19	39798557	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	695304	39798557	19330426	570	39460											
ZNF546	339327	broad.mit.edu	37	chr19	40519724	40519724	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcagtgtaaacatgaatttGagagacaagagagacatcag	17	8	11	5	0	1	5	1	2	0	3	1	7	1	5	0	0	2	2	0	0	4	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:40519724G>C	uc002oms.2	+	7	803	c.547G>C	c.(547-549)GAG>CAG	p.E183Q	ZNF546_uc002omt.2_Missense_Mutation_p.E157Q	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	183					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					ACATGAATTTGAGAGACAAGA	0.358													22	32					0	0	0	0	C	40519724	C	C	40519724	3	2	214	1	0	0	0	0	1	0	0	0	18045	1291	45	2	565	2	ZNF546	19	40519724	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	721167	40519724	18609259	571	39461											
LTBP4	8425	broad.mit.edu	37	chr19	41125251	41125251	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgttgtctcctgcttacaGatgtgaacgagtgtgaaaca	10	12	10	9	1	1	3	0	2	1	1	2	4	1	3	2	0	4	2	2	0	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:41125251G>A	uc002ooh.1	+	26	3272	c.3272_splice	c.e26-1	p.D1091_splice	LTBP4_uc002oog.1_Splice_Site_p.D1054_splice|LTBP4_uc002ooi.1_Splice_Site_p.D1024_splice|LTBP4_uc002ooj.1_Splice_Site|LTBP4_uc002ook.1_Splice_Site_p.D225_splice|LTBP4_uc002ool.1_Splice_Site_p.D103_splice|LTBP4_uc002oom.1_Splice_Site|LTBP4_uc010xvp.1_Splice_Site	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding						growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCTGCTTACAGATGTGAACGA	0.468													38	104					0	0	0	0	A	41125251	A	A	41125251	5	1	214	1	0	0	0	0	0	0	1	0	9126	956	33	2	3661	2	LTBP4	19	41125251	Splice_Site	SNP	G	TCGA-CV-6961-01A-21D-1912-08	605527	41125251	18003732	572	39462											
SNRPA	6626	broad.mit.edu	37	chr19	41257373	41257373	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaacaacctcaatgagaaGatcaagaaggatggtgagtt	17	8	10	6	0	3	4	3	2	0	3	3	6	3	5	1	2	2	1	1	2	6	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:41257373G>C	uc002ooz.2	+	1	595	c.60G>C	c.(58-60)AAG>AAC	p.K20N	C19orf54_uc002oou.1_5'Flank|C19orf54_uc002oow.1_5'Flank|C19orf54_uc002oox.1_5'Flank|C19orf54_uc002ooy.1_5'Flank|C19orf54_uc010xvs.1_5'Flank	NM_004596	NP_004587	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A	20	RRM 1.					nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			skin(2)|ovary(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TCAATGAGAAGATCAAGAAGG	0.403													47	91					0	0	0	0	C	41257373	C	C	41257373	3	2	214	1	0	0	0	0	1	0	0	0	14923	933	33	2	62	2	SNRPA	19	41257373	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	132122	41257373	17871610	573	39463											
CYP2F1	1572	broad.mit.edu	37	chr19	41630772	41630772	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaacttgccgcaccgcgtCactagggacacggcctttcg	8	8	11	14	5	1	1	1	1	0	0	2	2	1	2	3	2	2	1	3	2	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:41630772C>T	uc002opu.1	+	8	1169	c.1113C>T	c.(1111-1113)GTC>GTT	p.V371V	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_3'UTR|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	371					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						CGCACCGCGTCACTAGGGACA	0.617													5	24					0	0	0	0	T	41630772	T	T	41630772	2	4	214	1	0	0	0	0	0	0	0	1	4188	813	29	2		2	CYP2F1	19	41630772	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	373399	41630772	17498211	574	39464											
C19orf61	56006	broad.mit.edu	37	chr19	44251656	44251656	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttgatgctgtgcttcatgcGctctgggggcagtagtttgg	4	14	15	8	1	2	1	1	1	1	0	2	1	2	1	0	3	3	6	0	3	1	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:44251656G>T	uc002oxj.2	-	5	869	c.526C>A	c.(526-528)CGC>AGC	p.R176S	C19orf61_uc002oxk.2_Missense_Mutation_p.R176S|C19orf61_uc010eiy.1_Missense_Mutation_p.R176S	NM_019108	NP_061981	Q9H0W8	SMG9_HUMAN	SMG9 protein	176					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding				0		Prostate(69;0.0352)				TGCTTCATGCGCTCTGGGGGC	0.572													4	60					0.00909568	0.00929702	1	0	T	44251656	T	T	44251656	3	4	214	1	0	0	0	0	1	0	0	0	1952	1087	38	3	1076	3	C19orf61	19	44251656	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2620884	44251656	14877327	575	39465											
BLOC1S3	388552	broad.mit.edu	37	chr19	45683082	45683082	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctggccgagcgtctggacatCgtggctggctgccgcctgct	3	9	15	14	4	1	0	0	0	1	0	2	2	1	1	3	4	3	3	3	4	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:45683082C>G	uc002pax.3	+	2	624	c.528C>G	c.(526-528)ATC>ATG	p.I176M	TRAPPC6A_uc002pav.2_5'Flank|TRAPPC6A_uc002paw.2_5'Flank	NM_212550	NP_997715	Q6QNY0	BL1S3_HUMAN	biogenesis of lysosomal organelles complex-1,	176					cellular membrane organization|eye development|melanosome organization|platelet activation|platelet dense granule organization|post-Golgi vesicle-mediated transport	BLOC-1 complex	identical protein binding				0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		GTCTGGACATCGTGGCTGGCT	0.726									Hermansky-Pudlak_syndrome				9	22					0	0	0	0	G	45683082	G	G	45683082	3	3	214	1	0	0	0	0	1	0	0	0	1453	874	31	3	530	3	BLOC1S3	19	45683082	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1431426	45683082	13445901	576	39466											
OPA3	80207	broad.mit.edu	37	chr19	46056955	46056955	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acctcgtcccgcagcgcgttCcaggcagcacgctgctcctc	5	7	10	19	5	0	0	0	0	0	0	5	0	3	0	4	1	3	6	4	1	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:46056955C>G	uc002pck.3	-	2	457	c.357G>C	c.(355-357)TGG>TGC	p.W119C	OPA3_uc002pcj.3_Intron|OPA3_uc010xxk.1_Missense_Mutation_p.W66C	NM_025136	NP_079412	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform b	119	Potential.				response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		GCAGCGCGTTCCAGGCAGCAC	0.716													6	20					0	0	0	0	G	46056955	G	G	46056955	3	3	214	1	0	0	0	0	1	0	0	0	10926	856	30	2	591	2	OPA3	19	46056955	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	373873	46056955	13072028	577	39467											
CCDC9	26093	broad.mit.edu	37	chr19	47763996	47763996	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagccccggggagcagcctcGaggaggaggagctgggggcc	7	2	20	12	2	0	0	0	0	0	0	1	5	0	4	4	7	4	2	4	7	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:47763996G>A	uc010xym.1	+	5	569	c.362G>A	c.(361-363)CGA>CAA	p.R121Q		NM_015603	NP_056418	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	121	Gly-rich.										0		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		GAGCAGCCTCGAGGAGGAGGA	0.716													12	24					0	0	0	0	A	47763996	A	A	47763996	3	1	214	1	0	0	0	0	1	0	0	0	2880	1058	37	1	376	1	CCDC9	19	47763996	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1707041	47763996	11364987	578	39468											
GLTSCR1	29998	broad.mit.edu	37	chr19	48185361	48185361	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcgccaaaggagctggcctCggccctcaggcccccgacag	7	4	13	17	3	1	0	1	0	0	0	3	2	1	1	5	4	1	1	5	4	1	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:48185361C>T	uc002phh.3	+	7	2429	c.2235C>T	c.(2233-2235)CTC>CTT	p.L745L	GLTSCR1_uc002phi.3_Silent_p.L503L	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	745							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		GAGCTGGCCTCGGCCCTCAGG	0.741													3	7					0	0	0	0	T	48185361	T	T	48185361	2	4	214	1	0	0	0	0	0	0	0	1	6511	871	31	1		1	GLTSCR1	19	48185361	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	421365	48185361	10943622	579	39469											
HRC	3270	broad.mit.edu	37	chr19	49657579	49657579	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtggagacatcatcatcatCattgtcatcttcttcatggc	10	14	7	10	0	8	1	6	0	2	1	8	2	8	1	0	2	0	0	0	2	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:49657579C>G	uc002pmv.2	-	1	1103	c.916G>C	c.(916-918)GAT>CAT	p.D306H		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	306	4 X tandem repeats, acidic.|1-3.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		TCATCATCATCATTGTCATCT	0.532													17	55					0	0	0	0	G	49657579	G	G	49657579	3	3	214	1	0	0	0	0	1	0	0	0	7391	826	29	2	1207	2	HRC	19	49657579	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1472218	49657579	9471404	580	39470											
ALDH16A1	126133	broad.mit.edu	37	chr19	49967126	49967126	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctaggtgttccaggctggtGatgtgccttcggaacgccca	6	10	13	12	2	0	1	0	1	0	0	2	2	1	2	4	4	2	2	4	4	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:49967126G>A	uc002pnt.2	+	9	1230	c.1114G>A	c.(1114-1116)GAT>AAT	p.D372N	ALDH16A1_uc010yar.1_Missense_Mutation_p.D321N|ALDH16A1_uc010yas.1_Missense_Mutation_p.D207N|ALDH16A1_uc010yat.1_Missense_Mutation_p.D209N	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	372							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CCAGGCTGGTGATGTGCCTTC	0.383													49	221					0	0	0	0	A	49967126	A	A	49967126	3	1	214	1	0	0	0	0	1	0	0	0	488	1290	45	2	1148	2	ALDH16A1	19	49967126	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	309547	49967126	9161857	581	39471											
KLK4	9622	broad.mit.edu	37	chr19	51410250	51410250	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcagaggttggtgtagacAcctggcacgccaacttggcc	8	9	13	11	1	0	2	0	0	0	2	0	2	0	2	3	4	2	4	3	4	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:51410250A>C	uc002pua.1	-	5	705	c.705T>G	c.(703-705)GGT>GGG	p.G235G	KLK4_uc002pty.1_3'UTR|KLK4_uc002ptz.1_RNA|KLK4_uc002pub.1_Silent_p.G140G|KLK4_uc002puc.1_RNA	NM_004917	NP_004908	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4 preproprotein	235	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		TGGTGTAGACACCTGGCACGC	0.552													33	96					0	0	0	0	C	51410250	C	C	51410250	2	2	214	1	0	0	0	0	0	0	0	1	8445	146	6	5		5	KLK4	19	51410250	Silent	SNP	A	TCGA-CV-6961-01A-21D-1912-08	1443124	51410250	7718733	582	39472											
ZNF766	90321	broad.mit.edu	37	chr19	52793884	52793884	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgagtgtggcaaggtcttCagtcgaattacataccttgt	11	13	10	7	1	2	1	1	1	1	0	3	2	2	1	1	2	2	1	1	2	5	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:52793884C>T	uc002pyr.1	+	4	883	c.840C>T	c.(838-840)TTC>TTT	p.F280F	ZNF766_uc002pys.1_3'UTR|ZNF766_uc002pyt.1_Silent_p.F295F	NM_001010851	NP_001010851	Q5HY98	ZN766_HUMAN	zinc finger protein 766	280	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		GCAAGGTCTTCAGTCGAATTA	0.403													7	24					0	0	0	0	T	52793884	T	T	52793884	2	4	214	1	0	0	0	0	0	0	0	1	18207	825	29	2		2	ZNF766	19	52793884	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1383634	52793884	6335099	583	39473											
ZNF816A	125893	broad.mit.edu	37	chr19	53454424	53454424	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccatacttattagaaatatGagttttgagcctacaagaaa	16	12	6	7	0	0	4	0	2	0	2	0	4	0	4	2	0	3	1	2	0	8	7			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:53454424G>A	uc002qal.1	-	5	905	c.604C>T	c.(604-606)CAT>TAT	p.H202Y	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.H186Y	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		TTAGAAATATGAGTTTTGAGC	0.368													19	66					0	0	0	0	A	53454424	A	A	53454424	3	1	214	1	0	0	0	0	1	0	0	0	18244	1290	45	2	1355	2	ZNF816A	19	53454424	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	660540	53454424	5674559	584	39474											
LILRA6	79168	broad.mit.edu	37	chr19	54744933	54744933	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgacatcagagccacactgGagggtcaggctctgcccagg	9	5	13	14	1	3	1	2	0	1	1	3	3	3	2	3	4	2	1	3	4	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:54744933G>A	uc002qeu.1	-	5	853	c.729C>T	c.(727-729)CTC>CTT	p.L243L	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Silent_p.L243L|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Silent_p.L243L|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Silent_p.L243L|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Silent_p.L243L|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Silent_p.L243L|LILRA6_uc010yeq.1_Silent_p.L243L|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Silent_p.L104L	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	243	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGCCACACTGGAGGGTCAGGC	0.637													13	95					0	0	0	0	A	54744933	A	A	54744933	2	1	214	1	0	0	0	0	0	0	0	1	8830	1161	41	2		2	LILRA6	19	54744933	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1290509	54744933	4384050	585	39475											
FCAR	2204	broad.mit.edu	37	chr19	55401037	55401037	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccatccaccaagattacacGacgcagaacttgatccgcat	13	8	6	14	3	0	3	0	1	0	2	3	4	3	3	4	0	2	2	4	0	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:55401037G>A	uc002qhr.1	+	5	869	c.672G>A	c.(670-672)ACG>ACA	p.T224T	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Silent_p.T175T|FCAR_uc010esi.1_Silent_p.T101T|FCAR_uc002qhu.1_Silent_p.T128T|FCAR_uc002qhv.1_Silent_p.T202T|FCAR_uc002qhw.1_Silent_p.T212T|FCAR_uc002qhx.1_Silent_p.T116T|FCAR_uc002qhy.1_Silent_p.T190T|FCAR_uc002qhz.1_Missense_Mutation_p.D188N|FCAR_uc002qia.1_Silent_p.T115T	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	224	Extracellular (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		AAGATTACACGACGCAGAACT	0.532													102	303					0	0	0	0	A	55401037	A	A	55401037	2	1	214	1	0	0	0	0	0	0	0	1	5805	1058	37	1		1	FCAR	19	55401037	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	656104	55401037	3727946	586	39476											
FCAR	2204	broad.mit.edu	37	chr19	55401049	55401049	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattacacgacgcagaacttGatccgcatggccgtggcagg	10	7	13	11	4	0	2	0	1	0	1	1	4	1	2	2	3	2	3	2	3	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:55401049G>C	uc002qhr.1	+	5	881	c.684G>C	c.(682-684)TTG>TTC	p.L228F	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Missense_Mutation_p.L179F|FCAR_uc010esi.1_Missense_Mutation_p.L105F|FCAR_uc002qhu.1_Missense_Mutation_p.L132F|FCAR_uc002qhv.1_Missense_Mutation_p.L206F|FCAR_uc002qhw.1_Missense_Mutation_p.L216F|FCAR_uc002qhx.1_Missense_Mutation_p.L120F|FCAR_uc002qhy.1_Missense_Mutation_p.L194F|FCAR_uc002qhz.1_Missense_Mutation_p.D192H|FCAR_uc002qia.1_Missense_Mutation_p.L119F	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	228	Helical; (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		CGCAGAACTTGATCCGCATGG	0.537													108	317					0	0	0	0	C	55401049	C	C	55401049	3	2	214	1	0	0	0	0	1	0	0	0	5805	1290	45	2	773	2	FCAR	19	55401049	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	12	55401049	3727934	587	39477											
ZNF784	147808	broad.mit.edu	37	chr19	56133815	56133815	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccaccctgcccgcctccctCggccccagccaagtggccat	5	5	8	23	2	0	0	0	0	0	0	2	0	1	0	9	2	2	0	9	2	1	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:56133815C>T	uc002qll.1	-	2	288	c.274G>A	c.(274-276)GAG>AAG	p.E92K	ZNF784_uc010etb.1_RNA	NM_203374	NP_976308	Q8NCA9	ZN784_HUMAN	zinc finger protein 784	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CCGCCTCCCTCGGCCCCAGCC	0.711													5	18					0	0	0	0	T	56133815	T	T	56133815	3	4	214	1	0	0	0	0	1	0	0	0	18223	893	31	1	701	1	ZNF784	19	56133815	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	732766	56133815	2995168	588	39478											
ZNF671	79891	broad.mit.edu	37	chr19	58233748	58233748	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atatccacctggtcatacacCcagggctcttctcctcgctc	7	11	6	17	1	3	0	1	0	2	0	7	0	4	0	4	2	1	2	4	2	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:58233748C>A	uc002qpz.3	-	3	423	c.324G>T	c.(322-324)TGG>TGT	p.W108C	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Missense_Mutation_p.W31C|ZNF671_uc010yhf.1_Missense_Mutation_p.W10C	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	108	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGTCATACACCCAGGGCTCTT	0.537													10	209					7.48243e-07	7.86306e-07	1	0	A	58233748	A	A	58233748	3	1	214	1	0	0	0	0	1	0	0	0	18145	624	22	4	1288	4	ZNF671	19	58233748	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2099933	58233748	895235	589	39479											
ZNF584	201514	broad.mit.edu	37	chr19	58921347	58921347	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcagggcttggtgatgtttGaggatgtgacggtatatttc	7	15	15	4	1	0	3	0	3	0	0	1	4	0	4	0	4	1	4	0	4	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr19:58921347G>C	uc002qsp.2	+	2	510	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	ZNF584_uc010yia.1_Intron|ZNF584_uc002qsr.2_Intron|ZNF584_uc010yib.1_Missense_Mutation_p.E12Q	NM_173548	NP_775819	Q8IVC4	ZN584_HUMAN	zinc finger protein 584	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;5.3e-17)|all_epithelial(17;3.71e-12)|Lung NSC(17;8.3e-05)|Colorectal(82;0.000147)|all_lung(17;0.000386)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0271)		GGTGATGTTTGAGGATGTGAC	0.498													23	81					0	0	0	0	C	58921347	C	C	58921347	3	2	214	1	0	0	0	0	1	0	0	0	18083	1291	45	2	64	2	ZNF584	19	58921347	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	687599	58921347	207636	590	39480											
TBC1D20	128637	broad.mit.edu	37	chr20	428599	428599	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacacttttcgtctgatctCatcagtcaggagccctcctt	7	13	6	15	1	4	1	3	1	2	0	7	2	5	2	3	1	1	0	3	1	0	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:428599C>A	uc002wds.2	-	2	328	c.190G>T	c.(190-192)GAG>TAG	p.E64*	TBC1D20_uc002wdv.2_5'UTR|TBC1D20_uc002wdt.2_RNA|TBC1D20_uc002wdu.2_RNA	NM_144628	NP_653229	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	64	Rab-GAP TBC.				interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)	1		all_epithelial(17;0.228)|Breast(17;0.231)				CGTCTGATCTCATCAGTCAGG	0.532													13	47					6.31663e-08	6.68268e-08	1	0	A	428599	A	A	428599	4	1	214	1	0	0	0	0	0	1	0	0	15675	835	29	2	1049	2	TBC1D20	20	428599	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08		428599	62596921	591	39481											
TMC2	117532	broad.mit.edu	37	chr20	2560666	2560666	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatggagttaaccttgtcctTtttggcttaatatttggtct	7	20	8	6	0	1	0	0	0	1	0	2	1	2	1	2	3	1	2	2	3	4	8			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:2560666T>A	uc002wgf.1	+	7	813	c.798T>A	c.(796-798)CTT>CTA	p.L266L	TMC2_uc002wgg.1_Silent_p.L250L|TMC2_uc010zpw.1_Silent_p.L98L|TMC2_uc010zpx.1_Silent_p.L97L	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	266	Helical; (Potential).					integral to membrane				ovary(3)	3						ACCTTGTCCTTTTTGGCTTAA	0.393													6	82					0	0	0	0	A	2560666	A	A	2560666	2	1	214	1	0	0	0	0	0	0	0	1	16051	1828	64	5		5	TMC2	20	2560666	Silent	SNP	T	TCGA-CV-6961-01A-21D-1912-08	2132067	2560666	60464854	592	39482											
C20orf194	25943	broad.mit.edu	37	chr20	3299010	3299010	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atcctaaacaaccattgcctCccagtaagtcaggaatgtca	14	9	6	12	0	2	0	2	0	0	0	4	1	4	1	4	1	3	1	4	1	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:3299010C>A	uc002wii.2	-	17	1445	c.1394G>T	c.(1393-1395)GGA>GTA	p.G465V	C20orf194_uc002wij.3_Missense_Mutation_p.G204V|C20orf194_uc002wik.2_Missense_Mutation_p.G139V	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	465											0						ACCATTGCCTCCCAGTAAGTC	0.388													25	61					3.73148e-12	4.03472e-12	1	0	A	3299010	A	A	3299010	3	1	214	1	0	0	0	0	1	0	0	0	2109	855	30	2	2223	2	C20orf194	20	3299010	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	738344	3299010	59726510	593	39483											
PRND	23627	broad.mit.edu	37	chr20	4705248	4705248	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccactgtctgcatgctgctCttcagccacctctctgcggt	4	12	9	16	1	4	0	1	0	3	0	5	0	4	0	3	1	5	3	3	1	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:4705248C>G	uc002wkz.2	+	2	122	c.51C>G	c.(49-51)CTC>CTG	p.L17L		NM_012409	NP_036541	Q9UKY0	PRND_HUMAN	prion-like protein doppel preproprotein	17					protein homooligomerization	anchored to membrane|plasma membrane					0						GCATGCTGCTCTTCAGCCACC	0.632													23	64					0	0	0	0	G	4705248	G	G	4705248	2	3	214	1	0	0	0	0	0	0	0	1	12605	900	32	2		2	PRND	20	4705248	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1406238	4705248	58320272	594	39484											
DTD1	92675	broad.mit.edu	37	chr20	18724748	18724748	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttttatttaatcagctgtCaaagctcgaaaaacagcagc	15	12	6	8	1	2	0	2	0	0	0	3	1	2	0	0	0	5	3	0	0	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:18724748C>G	uc002wrf.3	+	5	643	c.482C>G	c.(481-483)TCA>TGA	p.S161*		NM_080820	NP_543010	Q8TEA8	DTD1_HUMAN	D-tyrosyl-tRNA deacylase 1	161					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds			ovary(2)	2						aatCAGCTGTCAAAGCTCGAA	0.408													5	8					0	0	0	0	G	18724748	G	G	18724748	4	3	214	1	0	0	0	0	0	1	0	0	4808	838	29	2	500	2	DTD1	20	18724748	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	14019500	18724748	44300772	595	39485											
MYH7B	57644	broad.mit.edu	37	chr20	33567491	33567491	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtgcgtgaagccgagctgCagcccatgaacccgcctcgc	7	6	13	15	4	0	2	0	2	0	0	1	3	0	2	4	1	6	2	4	1	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:33567491C>T	uc010gfa.1	+	4	347	c.226C>T	c.(226-228)CAG>TAG	p.Q76*	MYH7B_uc002xbi.1_Nonsense_Mutation_p.Q118*			A7E2Y1	MYH7B_HUMAN	RecName: Full=Myosin-7B; AltName: Full=Myosin heavy chain 7B, cardiac muscle beta isoform; AltName: Full=Myosin cardiac muscle beta chain; AltName: Full=Antigen MLAA-21; AltName: Full=Slow A MYH14;	76						membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGCCGAGCTGCAGCCCATGAA	0.647													25	87					0	0	0	0	T	33567491	T	T	33567491	4	4	214	1	0	0	0	0	0	1	0	0	10093	711	25	4	370	4	MYH7B	20	33567491	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	14842743	33567491	29458029	596	39486											
CEP250	11190	broad.mit.edu	37	chr20	34054793	34054793	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggtttctgaacacacagttCttcaagggctacctgaaagg	11	10	11	9	0	3	2	1	2	2	0	3	2	3	2	1	3	2	3	1	3	4	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:34054793C>T	uc002xcm.2	+	9	1166	c.495C>T	c.(493-495)TTC>TTT	p.F165F	CEP250_uc010zve.1_5'UTR|CEP250_uc010gfe.1_RNA|CEP250_uc010zvd.1_RNA|CEP250_uc002xco.2_5'UTR	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	165					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			ACACACAGTTCTTCAAGGGCT	0.522													18	42					0	0	0	0	T	34054793	T	T	34054793	2	4	214	1	0	0	0	0	0	0	0	1	3267	912	32	2		2	CEP250	20	34054793	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	487302	34054793	28970727	597	39487			4	60		3	3	88	N	G_C	1.693259e-06
CEP250	11190	broad.mit.edu	37	chr20	34054830	34054830	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggggagcacggtcgccttCtcagtctatggcgggaggtt	7	9	16	9	3	2	0	1	0	2	0	4	2	2	2	1	6	1	2	1	6	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:34054830C>T	uc002xcm.2	+	9	1203	c.532C>T	c.(532-534)CTC>TTC	p.L178F	CEP250_uc010zve.1_5'UTR|CEP250_uc010gfe.1_RNA|CEP250_uc010zvd.1_RNA|CEP250_uc002xco.2_5'UTR	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	178					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CGGTCGCCTTCTCAGTCTATG	0.532													17	45					0	0	0	0	T	34054830	T	T	34054830	3	4	214	1	0	0	0	0	1	0	0	0	3267	913	32	2	550	2	CEP250	20	34054830	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	37	34054830	28970690	598	39488			4	60		3	3	88	N	G_C	1.693259e-06
CEP250	11190	broad.mit.edu	37	chr20	34054880	34054880	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgacgccacttcctggaaatGaagtcagctactgacaggtc	11	8	10	12	2	1	2	1	2	0	0	3	4	2	3	2	2	2	1	2	2	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:34054880G>C	uc002xcm.2	+	9	1253	c.582G>C	c.(580-582)ATG>ATC	p.M194I	CEP250_uc010zve.1_5'UTR|CEP250_uc010gfe.1_RNA|CEP250_uc010zvd.1_RNA|CEP250_uc002xco.2_Missense_Mutation_p.M1I	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	194					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TCCTGGAAATGAAGTCAGCTA	0.527													16	45					0	0	0	0	C	34054880	C	C	34054880	3	2	214	1	0	0	0	0	1	0	0	0	3267	1290	45	2	600	2	CEP250	20	34054880	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	50	34054880	28970640	599	39489			4	60		3	3	88	N	G_C	1.693259e-06
SPAG4	6676	broad.mit.edu	37	chr20	34206846	34206846	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgccctccctccttgcagaGagtggccaagctcgtgttcc	5	10	10	16	2	0	1	0	0	0	1	5	2	3	1	5	1	2	3	5	1	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:34206846G>C	uc002xdb.1	+	8	836	c.719G>C	c.(718-720)AGA>ACA	p.R240T	SPAG4_uc010zvi.1_Missense_Mutation_p.R163T	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	240	Potential.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			TCCTTGCAGAGAGTGGCCAAG	0.582													14	57					0	0	0	0	C	34206846	C	C	34206846	3	2	214	1	0	0	0	0	1	0	0	0	15046	956	33	2	749	2	SPAG4	20	34206846	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	151966	34206846	28818674	600	39490											
DLGAP4	22839	broad.mit.edu	37	chr20	35155390	35155390	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcagccaccgagagcgcaGacagcatcgagatttatgtc	12	7	10	12	3	1	3	1	0	0	3	3	5	1	3	2	0	3	2	2	0	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:35155390G>C	uc002xff.2	+	13	3361	c.2926G>C	c.(2926-2928)GAC>CAC	p.D976H	DLGAP4_uc010zvp.1_Missense_Mutation_p.D976H|DLGAP4_uc002xfg.2_Missense_Mutation_p.D272H|DLGAP4_uc002xfh.2_Missense_Mutation_p.D440H|DLGAP4_uc002xfi.2_3'UTR|DLGAP4_uc002xfj.2_Missense_Mutation_p.D272H|uc002xfk.3_Intron	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	979					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CGAGAGCGCAGACAGCATCGA	0.557													10	50					0	0	0	0	C	35155390	C	C	35155390	3	2	214	1	0	0	0	0	1	0	0	0	4584	942	33	2	3096	2	DLGAP4	20	35155390	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	948544	35155390	27870130	601	39491											
SDC4	6385	broad.mit.edu	37	chr20	43964468	43964468	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtcatcagattcctgcccGggccccactacatcctcatc	9	9	6	17	1	3	1	3	0	0	1	6	1	5	1	5	1	2	0	5	1	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:43964468G>A	uc002xnu.2	-	2	193	c.153C>T	c.(151-153)CCC>CCT	p.P51P	SDC4_uc010zws.1_Intron	NM_002999	NP_002990	P31431	SDC4_HUMAN	syndecan 4 precursor	51	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity				0		Myeloproliferative disorder(115;0.0122)				ATTCCTGCCCGGGCCCCACTA	0.582													31	47					0	0	0	0	A	43964468	A	A	43964468	2	1	214	1	0	0	0	0	0	0	0	1	14019	1103	39	1		1	SDC4	20	43964468	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	8809078	43964468	19061052	602	39492											
NFATC2	4773	broad.mit.edu	37	chr20	50140540	50140540	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaatcggccggggggctcGccagagagactagcaagggg	9	3	18	11	4	0	2	0	0	0	2	2	4	0	2	3	6	1	2	3	6	3	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:50140540G>A	uc002xwd.2	-	2	460	c.240C>T	c.(238-240)GGC>GGT	p.G80G	NFATC2_uc002xwc.2_Silent_p.G80G|NFATC2_uc010zyv.1_Intron|NFATC2_uc010zyw.1_Intron|NFATC2_uc010zyx.1_Silent_p.G60G|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Silent_p.G60G	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	80					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					CGGGGGGCTCGCCAGAGAGAC	0.657													22	75					0	0	0	0	A	50140540	A	A	50140540	2	1	214	1	0	0	0	0	0	0	0	1	10416	1074	38	1		1	NFATC2	20	50140540	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	6176072	50140540	12884980	603	39493											
LSM14B	149986	broad.mit.edu	37	chr20	60706468	60706468	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtggtgacccagagtgccGaagcgcccgctgaggaagac	9	5	15	12	3	0	4	0	2	0	2	0	6	0	5	3	2	2	1	3	2	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:60706468G>A	uc010gjy.1	+	7	1098	c.892G>A	c.(892-894)GAA>AAA	p.E298K	LSM14B_uc002ybv.2_Missense_Mutation_p.E272K|LSM14B_uc010zzz.1_Missense_Mutation_p.E218K	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	298					multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CCAGAGTGCCGAAGCGCCCGC	0.537													7	27					0	0	0	0	A	60706468	A	A	60706468	3	1	214	1	0	0	0	0	1	0	0	0	9105	1059	37	1	918	1	LSM14B	20	60706468	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	10565928	60706468	2319052	604	39494											
GTPBP5	26164	broad.mit.edu	37	chr20	60775858	60775858	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtggatctttctcagcctGagccgtggactcaagttgac	7	12	12	10	1	3	2	2	2	2	0	4	4	3	4	2	3	2	1	2	3	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:60775858G>C	uc002yce.3	+	7	984	c.946G>C	c.(946-948)GAG>CAG	p.E316Q	GTPBP5_uc011aab.1_Missense_Mutation_p.E88Q|GTPBP5_uc011aac.1_Missense_Mutation_p.E88Q|GTPBP5_uc011aad.1_Missense_Mutation_p.E88Q|GTPBP5_uc011aae.1_Missense_Mutation_p.E88Q|GTPBP5_uc011aaf.1_Missense_Mutation_p.E158Q	NM_015666	NP_056481	Q9H4K7	GTPB5_HUMAN	GTP binding protein 5	316	G.|Localized in the mitocondria.|Not localized in the mitocondria.				ribosome biogenesis	mitochondrion	GTP binding|GTPase activity|magnesium ion binding				0	Breast(26;3.52e-09)		BRCA - Breast invasive adenocarcinoma(19;2.5e-08)			TTCTCAGCCTGAGCCGTGGAC	0.547													63	215					0	0	0	0	C	60775858	C	C	60775858	3	2	214	1	0	0	0	0	1	0	0	0	6922	1291	45	2	968	2	GTPBP5	20	60775858	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	69390	60775858	2249662	605	39495											
LAMA5	3911	broad.mit.edu	37	chr20	60942119	60942119	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctcctctccgcaggtcgcGgaggcggcgatgcgggcgcc	3	5	17	16	7	1	0	0	0	1	0	4	2	2	1	4	5	1	1	4	5	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ea8183de-8f9b-4d30-a23b-c6ffc183f22b	g.chr20:60942119G>A	uc002ycq.2	-	1	250	c.183C>T	c.(181-183)TCC>TCT	p.S61S		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	61	Laminin N-terminal.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGCAGGTCGCGGAGGCGGCGA	0.363													2	0					0	0	0	0	A	60942119	A	A	60942119	2	1	214	1	0	0	0	0	0	0	0	1	8649	1103	39	1		1	LAMA5	20	60942119	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	166261	60942119	2083401	606	39496											
RTEL1	51750	broad.mit.edu	37	chr20	62298846	62298846	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgcccttactacctgtcccgGaacctgaagcagcaagccga	10	7	9	15	2	0	1	0	1	0	0	1	3	1	2	5	1	7	2	5	1	5	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:62298846G>C	uc002yfu.1	+	8	982	c.639G>C	c.(637-639)CGG>CGC	p.R213R	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Silent_p.R213R|RTEL1_uc011abd.1_Silent_p.R237R|RTEL1_uc002yfv.2_Silent_p.R263R|RTEL1_uc011abe.1_5'UTR|RTEL1_uc002yfw.2_RNA	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	213	Helicase ATP-binding.				DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			ACCTGTCCCGGAACCTGAAGC	0.572													61	145					0	0	0	0	C	62298846	C	C	62298846	2	2	214	1	0	0	0	0	0	0	0	1	13785	1161	41	2		2	RTEL1	20	62298846	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1356727	62298846	726674	607	39497											
PCMTD2	55251	broad.mit.edu	37	chr20	62904683	62904683	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaacggaaacggactaaaGaacacccccaggtttaaacg	19	4	8	10	3	0	1	0	0	0	1	0	3	0	3	2	3	4	1	2	3	8	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr20:62904683G>C	uc002yil.3	+	6	1016	c.816G>C	c.(814-816)AAG>AAC	p.K272N	PCMTD2_uc002yim.3_Missense_Mutation_p.K245N	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	272						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					ACGGACTAAAGAACACCCCCA	0.493													27	87					0	0	0	0	C	62904683	C	C	62904683	3	2	214	1	0	0	0	0	1	0	0	0	11641	933	33	2	834	2	PCMTD2	20	62904683	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	605837	62904683	120837	608	39498											
KRTAP27-1	643812	broad.mit.edu	37	chr21	31709486	31709486	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctacaggaactggattcaggGttctgagactgacactgaca	12	9	11	9	0	2	3	1	3	1	1	2	6	2	5	0	3	2	1	0	3	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:31709486G>A	uc002ynx.1	-	1	527	c.501C>T	c.(499-501)AAC>AAT	p.N167N		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	167						intermediate filament				ovary(2)	2						TGGATTCAGGGTTCTGAGACT	0.478													31	78					0	0	0	0	A	31709486	A	A	31709486	2	1	214	1	0	0	0	0	0	0	0	1	8584	1252	44	4		4	KRTAP27-1	21	31709486	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08		31709486	16420409	609	39499											
TIAM1	7074	broad.mit.edu	37	chr21	32493057	32493057	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggggctgctgggactcttTctccgggctgcttgcggaga	3	10	18	10	2	2	1	0	0	2	1	3	3	2	2	1	6	3	4	1	6	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:32493057T>C	uc002yow.1	-	29	4877	c.4405A>G	c.(4405-4407)AAA>GAA	p.K1469E	TIAM1_uc011adk.1_3'UTR|TIAM1_uc011adl.1_Missense_Mutation_p.K1409E	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1469					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TGGGACTCTTTCTCCGGGCTG	0.577													3	58					0	0	0	0	C	32493057	C	C	32493057	3	2	214	1	0	0	0	0	1	0	0	0	15956	1792	62	5	374	5	TIAM1	21	32493057	Missense_Mutation	SNP	T	TCGA-CV-6961-01A-21D-1912-08	783571	32493057	15636838	610	39500											
RUNX1	861	broad.mit.edu	37	chr21	36171624	36171624	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcgactggaaagttctgcaGagagggttgtcatgccgctg	8	10	15	8	2	2	1	1	0	1	1	3	4	2	2	1	2	2	4	1	2	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:36171624G>A	uc002yuh.2	-	5	2438	c.860C>T	c.(859-861)TCT>TTT	p.S287F	RUNX1_uc002yui.2_Missense_Mutation_p.S223F|RUNX1_uc010gmu.2_Missense_Mutation_p.S314F|RUNX1_uc010gmv.2_Missense_Mutation_p.S314F|RUNX1_uc002yuj.3_Missense_Mutation_p.S182F|RUNX1_uc002yuk.3_Missense_Mutation_p.S314F|RUNX1_uc002yul.1_Missense_Mutation_p.S79F|RUNX1_uc002yum.1_Missense_Mutation_p.S118F	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	287	Pro/Ser/Thr-rich.			Missing: No DNA-binding.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.Y287fs*197(1)|p.S314fs*168(1)		haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						AAGTTCTGCAGAGAGGGTTGT	0.532			T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				6	97					0	0	0	0	A	36171624	A	A	36171624	3	1	214	1	0	0	0	0	1	0	0	0	13811	942	33	2	509	2	RUNX1	21	36171624	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3678567	36171624	11958271	611	39501											
RUNX1	861	broad.mit.edu	37	chr21	36171681	36171681	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggcgttgctgggtgcacaGaaggagaggcaatggatccc	9	7	17	8	1	0	2	0	0	0	2	1	4	1	3	1	5	2	4	1	5	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:36171681G>A	uc002yuh.2	-	5	2381	c.803C>T	c.(802-804)TCT>TTT	p.S268F	RUNX1_uc002yui.2_Missense_Mutation_p.S204F|RUNX1_uc010gmu.2_Missense_Mutation_p.S295F|RUNX1_uc010gmv.2_Missense_Mutation_p.S295F|RUNX1_uc002yuj.3_Missense_Mutation_p.S163F|RUNX1_uc002yuk.3_Missense_Mutation_p.S295F|RUNX1_uc002yul.1_Missense_Mutation_p.S60F|RUNX1_uc002yum.1_Missense_Mutation_p.S99F	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	268	Pro/Ser/Thr-rich.			Missing: No DNA-binding.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						TGGGTGCACAGAAGGAGAGGC	0.522			T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				7	79					0	0	0	0	A	36171681	A	A	36171681	3	1	214	1	0	0	0	0	1	0	0	0	13811	942	33	2	566	2	RUNX1	21	36171681	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	57	36171681	11958214	612	39502											
ETS2	2114	broad.mit.edu	37	chr21	40191453	40191453	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaaagaccacgactcccctGagaacggtgcggacagcttc	11	5	10	15	3	0	2	0	1	0	2	2	5	1	3	4	2	3	1	4	2	2	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:40191453G>A	uc002yxg.2	+	8	1034	c.838G>A	c.(838-840)GAG>AAG	p.E280K	ETS2_uc002yxf.2_Missense_Mutation_p.E420K	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	280					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				CGACTCCCCTGAGAACGGTGC	0.557													46	34					0	0	0	0	A	40191453	A	A	40191453	3	1	214	1	0	0	0	0	1	0	0	0	5300	1291	45	2	864	2	ETS2	21	40191453	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4019772	40191453	7938442	613	39503											
ETS2	2114	broad.mit.edu	37	chr21	40194646	40194646	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ataagcccaagatgaactacGagaagctgagccggggctta	14	6	12	9	2	0	4	0	2	0	2	0	5	0	4	2	2	5	2	2	2	6	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:40194646G>A	uc002yxg.2	+	10	1439	c.1243G>A	c.(1243-1245)GAG>AAG	p.E415K	ETS2_uc002yxf.2_Missense_Mutation_p.E555K	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	415	ETS.				positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				GATGAACTACGAGAAGCTGAG	0.493													60	44					0	0	0	0	A	40194646	A	A	40194646	3	1	214	1	0	0	0	0	1	0	0	0	5300	1059	37	1	1277	1	ETS2	21	40194646	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3193	40194646	7935249	614	39504											
ETS2	2114	broad.mit.edu	37	chr21	40194812	40194812	+	Nonstop_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcccgacacggaggactGaggtcgccgggaccaccctg	8	3	14	16	4	0	1	0	1	0	0	1	5	0	4	5	4	1	0	5	4	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:40194812G>T	uc002yxg.2	+	10	1605	c.1409G>T	c.(1408-1410)TGA>TTA	p.*470L	ETS2_uc002yxf.2_Nonstop_Mutation_p.*610L	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	470					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				ACGGAGGACTGAGGTCGCCGG	0.657													31	11					1.74807e-11	1.88235e-11	1	0	T	40194812	T	T	40194812	4	4	214	1	0	0	0	0	0	0	0	0	5300	1285	45	2	1443	2	ETS2	21	40194812	Nonstop_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	166	40194812	7935083	615	39505											
PSMG1	8624	broad.mit.edu	37	chr21	40549373	40549373	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccttaccttaaccaaaccCttcaagcttctggtagaaag	14	10	5	12	0	2	1	1	0	1	1	2	1	2	1	4	1	5	2	4	1	7	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:40549373C>G	uc002yxi.2	-	6	909	c.780G>C	c.(778-780)AAG>AAC	p.K260N	PSMG1_uc002yxj.2_Missense_Mutation_p.K239N|PSMG1_uc010gob.2_Missense_Mutation_p.K173N	NM_003720	NP_003711	O95456	PSMG1_HUMAN	Down syndrome critical region protein 2 isoform	260					proteasome assembly	endoplasmic reticulum	protein binding				0		Prostate(19;8.44e-08)				TAACCAAACCCTTCAAGCTTC	0.323													8	21					0	0	0	0	G	40549373	G	G	40549373	3	3	214	1	0	0	0	0	1	0	0	0	12773	680	24	4	94	4	PSMG1	21	40549373	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	354561	40549373	7580522	616	39506											
FAM3B	54097	broad.mit.edu	37	chr21	42694889	42694889	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggtcttcgcctccttgtGtgcctggtattcggggtacc	2	14	13	12	3	1	0	0	0	1	0	4	0	2	0	4	4	2	2	4	4	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:42694889G>T	uc002yzb.1	+	2	205	c.59G>T	c.(58-60)TGT>TTT	p.C20F	FAM3B_uc002yza.2_RNA|FAM3B_uc002yzc.1_Intron|FAM3B_uc002yzd.1_Missense_Mutation_p.C43F|FAM3B_uc011aeq.1_Missense_Mutation_p.C34F	NM_058186	NP_478066	P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	20					apoptosis|insulin secretion	extracellular space	cytokine activity				0		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				GCCTCCTTGTGTGCCTGGTAT	0.622													9	44					0.000442599	0.000456558	1	0	T	42694889	T	T	42694889	3	4	214	1	0	0	0	0	1	0	0	0	5589	1377	48	4	65	4	FAM3B	21	42694889	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2145516	42694889	5435006	617	39507											
RRP1B	23076	broad.mit.edu	37	chr21	45104516	45104516	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttcaacaggaagcgcctctCcaaactcatcaagaagtcag	14	7	7	13	1	5	1	4	0	1	1	6	2	5	2	2	1	3	0	2	1	5	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:45104516C>G	uc002zdk.2	+	10	1088	c.974C>G	c.(973-975)TCC>TGC	p.S325C	RRP1B_uc002zdl.2_5'Flank	NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	325					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		AAGCGCCTCTCCAAACTCATC	0.488													4	44					0	0	0	0	G	45104516	G	G	45104516	3	3	214	1	0	0	0	0	1	0	0	0	13753	855	30	2	1012	2	RRP1B	21	45104516	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	2409627	45104516	3025379	618	39508											
KRTAP10-1	386677	broad.mit.edu	37	chr21	45959218	45959218	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgggagcacgcggggcggcaGaggagggacacgcaggaggc	9	0	22	10	5	0	1	0	0	0	1	0	5	0	5	0	8	1	3	0	8	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:45959218G>A	uc002zfh.1	-	1	861	c.816C>T	c.(814-816)CTC>CTT	p.L272L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198691	NP_941964	P60331	KR101_HUMAN	keratin associated protein 10-1	272						keratin filament				skin(1)	1						CGGGGCGGCAGAGGAGGGACA	0.726													12	22					0	0	0	0	A	45959218	A	A	45959218	2	1	214	1	0	0	0	0	0	0	0	1	8544	929	33	2		2	KRTAP10-1	21	45959218	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	854702	45959218	2170677	619	39509			5	61		3	3	611	G		8.345093e-05
KRTAP10-1	386677	broad.mit.edu	37	chr21	45959660	45959660	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaagttggctggcagctaGactgctggcagcatgaagag	11	7	15	8	0	0	3	0	1	0	2	0	3	0	3	0	3	4	8	0	3	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:45959660G>C	uc002zfh.1	-	1	419	c.374C>G	c.(373-375)TCT>TGT	p.S125C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198691	NP_941964	P60331	KR101_HUMAN	keratin associated protein 10-1	125	10.|24 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						CTGGCAGCTAGACTGCTGGCA	0.373													32	113					0	0	0	0	C	45959660	C	C	45959660	3	2	214	1	0	0	0	0	1	0	0	0	8544	942	33	2	478	2	KRTAP10-1	21	45959660	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	442	45959660	2170235	620	39510			5	61		3	3	611	G		8.345093e-05
KRTAP10-1	386677	broad.mit.edu	37	chr21	45959828	45959828	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaggagctggtgcagcctGattggcaggggctgggctca	6	8	18	9	0	1	1	1	1	0	0	1	2	1	2	1	6	4	6	1	6	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:45959828G>A	uc002zfh.1	-	1	251	c.206C>T	c.(205-207)TCA>TTA	p.S69L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198691	NP_941964	P60331	KR101_HUMAN	keratin associated protein 10-1	69	24 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						GGTGCAGCCTGATTGGCAGGG	0.498													20	75					0	0	0	0	A	45959828	A	A	45959828	3	1	214	1	0	0	0	0	1	0	0	0	8544	1294	45	2	646	2	KRTAP10-1	21	45959828	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	168	45959828	2170067	621	39511			5	61		3	3	611	G		8.345093e-05
KRTAP10-4	386672	broad.mit.edu	37	chr21	45994519	45994519	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catctgctctggggcttcctCtctgtgctgccagcagtcta	4	13	10	14	0	4	0	0	0	4	0	6	0	5	0	2	2	4	4	2	2	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:45994519C>G	uc002zfk.1	+	1	914	c.884C>G	c.(883-885)TCT>TGT	p.S295C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	295	36 X 5 AA repeats of C-C-X(3).					keratin filament					0						GGGGCTTCCTCTCTGTGCTGC	0.637													13	181					0	0	0	0	G	45994519	G	G	45994519	3	3	214	1	0	0	0	0	1	0	0	0	8550	913	32	2	886	2	KRTAP10-4	21	45994519	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	34691	45994519	2135376	622	39512											
PCNT	5116	broad.mit.edu	37	chr21	47773920	47773920	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttgtcctgtgtgggtttaGaagagaaacctgagaaagga	12	10	15	4	0	0	3	0	1	0	3	1	6	1	4	2	3	1	2	2	3	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr21:47773920G>A	uc002zji.3	+	11	1806	c.1699G>A	c.(1699-1701)GAA>AAA	p.E567K	PCNT_uc002zjj.2_Missense_Mutation_p.E449K	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	567	Glu-rich.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TGTGGGTTTAGAAGAGAAACC	0.498													3	14					0	0	0	0	A	47773920	A	A	47773920	3	1	214	1	0	0	0	0	1	0	0	0	11644	943	33	2	1741	2	PCNT	21	47773920	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1779401	47773920	355975	623	39513											
XKR3	150165	broad.mit.edu	37	chr22	17288751	17288751	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccccacaataataaagctGatggtaaatgacatccagaa	17	7	7	10	0	0	3	0	2	0	1	1	3	1	3	3	1	1	2	3	1	7	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:17288751G>A	uc002zlv.2	-	2	311	c.213C>T	c.(211-213)ATC>ATT	p.I71I	XKR3_uc011agf.1_Silent_p.I71I	NM_175878	NP_787074	Q5GH77	XKR3_HUMAN	X Kell blood group precursor-related family,	71	Helical; (Potential).					integral to membrane|plasma membrane				large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TAATAAAGCTGATGGTAAATG	0.358													16	46					0	0	0	0	A	17288751	A	A	17288751	2	1	214	1	0	0	0	0	0	0	0	1	17500	1280	45	2		2	XKR3	22	17288751	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08		17288751	34015815	624	39514											
CECR2	27443	broad.mit.edu	37	chr22	17956654	17956654	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagaagccgctcttcacagaGatgacgtggagtttatcagt	11	11	11	8	2	3	3	2	1	1	2	3	5	3	4	1	1	1	2	1	1	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:17956654G>C	uc010gqw.1	+	1	151	c.25G>C	c.(25-27)GAT>CAT	p.D9H	CECR2_uc010gqv.1_5'UTR|CECR2_uc002zml.2_5'UTR	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	51					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		TCTTCACAGAGATGACGTGGA	0.463													22	57					0	0	0	0	C	17956654	C	C	17956654	3	2	214	1	0	0	0	0	1	0	0	0	3221	933	33	2	29	2	CECR2	22	17956654	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	667903	17956654	33347912	625	39515											
SLC25A18	83733	broad.mit.edu	37	chr22	18072904	18072904	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catctgccttcatgaaaggcGctggctgccgggcactggtc	6	9	13	13	2	2	1	1	1	1	0	3	1	2	1	2	4	2	3	2	4	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:18072904G>A	uc002zmp.1	+	11	1344	c.850G>A	c.(850-852)GCT>ACT	p.A284T	SLC25A18_uc002zmq.1_Missense_Mutation_p.A284T	NM_031481	NP_113669	Q9H1K4	GHC2_HUMAN	solute carrier	284	Solcar 3.					integral to membrane|mitochondrial inner membrane	binding|symporter activity				0				Lung(27;0.124)	L-Glutamic Acid(DB00142)	CATGAAAGGCGCTGGCTGCCG	0.527													19	81					0	0	0	0	A	18072904	A	A	18072904	3	1	214	1	0	0	0	0	1	0	0	0	14544	1087	38	1	884	1	SLC25A18	22	18072904	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	116250	18072904	33231662	626	39516											
BID	637	broad.mit.edu	37	chr22	18220787	18220787	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctcaagggttcttacatttCtggctaagctcctcacgtag	8	13	8	12	1	4	0	2	0	2	0	5	0	5	0	2	2	2	4	2	2	4	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:18220787C>T	uc002znd.1	-	5	742	c.572G>A	c.(571-573)AGA>AAA	p.R191K	BID_uc002znc.1_Missense_Mutation_p.R237K|BID_uc002zne.1_Missense_Mutation_p.R95K|BID_uc010gra.1_RNA|BID_uc002znf.1_Missense_Mutation_p.R95K|BID_uc010grb.1_Missense_Mutation_p.R191K|BID_uc010grc.1_Missense_Mutation_p.R95K	NM_001196	NP_001187	P55957	BID_HUMAN	BH3 interacting domain death agonist isoform 2	191					activation of pro-apoptotic gene products|establishment of protein localization in membrane|induction of apoptosis by intracellular signals|induction of apoptosis via death domain receptors|neuron apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|release of cytochrome c from mitochondria	cytosol|membrane fraction|mitochondrial outer membrane	death receptor binding				0		all_epithelial(15;0.198)		Lung(27;0.0419)		TCTTACATTTCTGGCTAAGCT	0.552													24	66					0	0	0	0	T	18220787	T	T	18220787	3	4	214	1	0	0	0	0	1	0	0	0	1433	913	32	2	23	2	BID	22	18220787	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	147883	18220787	33083779	627	39517											
TUBA8	51807	broad.mit.edu	37	chr22	18604368	18604368	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgatgctcaagctagcaaGatcaacgatgatgactcctt	12	12	8	9	1	2	4	2	3	0	1	3	5	3	4	1	0	4	3	1	0	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:18604368G>C	uc002znv.1	+	2	199	c.126G>C	c.(124-126)AAG>AAC	p.K42N	TUBA8_uc002znr.2_5'UTR|TUBA8_uc002znw.1_Missense_Mutation_p.K66N|TUBA8_uc002znu.1_Missense_Mutation_p.K42N	NM_018943	NP_061816	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	42					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0						AAGCTAGCAAGATCAACGATG	0.552													12	53					0	0	0	0	C	18604368	C	C	18604368	3	2	214	1	0	0	0	0	1	0	0	0	16818	933	33	2	132	2	TUBA8	22	18604368	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	383581	18604368	32700198	628	39518											
TUBA8	51807	broad.mit.edu	37	chr22	18604405	18604405	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccttcaccacctttttcagcGagactggcaatgggaagcat	10	10	9	12	1	2	1	2	0	0	1	2	3	2	2	3	2	2	2	3	2	2	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:18604405G>A	uc002znv.1	+	2	236	c.163G>A	c.(163-165)GAG>AAG	p.E55K	TUBA8_uc002znr.2_5'UTR|TUBA8_uc002znw.1_Missense_Mutation_p.E79K|TUBA8_uc002znu.1_Missense_Mutation_p.E55K	NM_018943	NP_061816	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	55					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0						CTTTTTCAGCGAGACTGGCAA	0.557													9	56					0	0	0	0	A	18604405	A	A	18604405	3	1	214	1	0	0	0	0	1	0	0	0	16818	1059	37	1	169	1	TUBA8	22	18604405	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	37	18604405	32700161	629	39519											
CLTCL1	8218	broad.mit.edu	37	chr22	19207486	19207486	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcataccaggtagcgggcctCgcttttgaacagagaattct	10	10	11	10	2	1	2	0	1	1	1	2	3	1	2	2	2	3	3	2	2	4	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:19207486C>T	uc002zpb.2	-	18	2902	c.2827G>A	c.(2827-2829)GAG>AAG	p.E943K	CLTCL1_uc011agv.1_Missense_Mutation_p.E943K|CLTCL1_uc011agw.1_Missense_Mutation_p.E943K	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	943	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TAGCGGGCCTCGCTTTTGAAC	0.552			T	?	ALCL								38	130					0	0	0	0	T	19207486	T	T	19207486	3	4	214	1	0	0	0	0	1	0	0	0	3582	893	31	1	2155	1	CLTCL1	22	19207486	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	603081	19207486	32097080	630	39520											
PI4KA	5297	broad.mit.edu	37	chr22	21107310	21107310	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctcctcgttctccttggtCttggcctagagatgcaaaag	7	13	9	12	1	2	1	0	0	2	1	6	2	4	1	4	2	1	2	4	2	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:21107310C>T	uc002zsz.3	-	25	2925	c.2694G>A	c.(2692-2694)AAG>AAA	p.K898K		NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	898					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			TCTCCTTGGTCTTGGCCTAGA	0.537													29	50					0	0	0	0	T	21107310	T	T	21107310	2	4	214	1	0	0	0	0	0	0	0	1	11928	912	32	2		2	PI4KA	22	21107310	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1899824	21107310	30197256	631	39521											
ZNF70	7621	broad.mit.edu	37	chr22	24086061	24086061	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccggaaggacttgccgcacaGattgcacacgtagggcttct	9	8	12	12	3	1	1	0	0	1	1	1	3	1	3	2	3	2	4	2	3	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:24086061G>A	uc002zxs.2	-	2	1728	c.1267C>T	c.(1267-1269)CTG>TTG	p.L423L	ZNF70_uc002zxr.1_5'Flank	NM_021916	NP_068735	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	423	C2H2-type 11.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TTGCCGCACAGATTGCACACG	0.547													59	119					0	0	0	0	A	24086061	A	A	24086061	2	1	214	1	0	0	0	0	0	0	0	1	18170	933	33	2		2	ZNF70	22	24086061	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2978751	24086061	27218505	632	39522											
ZNF70	7621	broad.mit.edu	37	chr22	24086776	24086776	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtggatgatctggtgcctGagcaggtgggagctctggct	5	11	18	7	0	2	2	0	2	2	0	2	4	2	4	1	5	3	3	1	5	0	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:24086776G>C	uc002zxs.2	-	2	1013	c.552C>G	c.(550-552)CTC>CTG	p.L184L	ZNF70_uc002zxr.1_5'Flank	NM_021916	NP_068735	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	184	C2H2-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TCTGGTGCCTGAGCAGGTGGG	0.622													13	48					0	0	0	0	C	24086776	C	C	24086776	2	2	214	1	0	0	0	0	0	0	0	1	18170	1277	45	2		2	ZNF70	22	24086776	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	715	24086776	27217790	633	39523											
UPB1	51733	broad.mit.edu	37	chr22	24911253	24911253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtgaacatttgctacgggCggcaccaccccctcaactgg	8	7	11	15	3	1	1	1	1	0	0	1	1	1	1	3	4	4	2	3	4	3	2	rs144135211		TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:24911253C>T	uc003aaf.2	+	6	827	c.706C>T	c.(706-708)CGG>TGG	p.R236W	UPB1_uc003aae.2_Missense_Mutation_p.R168W|UPB1_uc011ajt.1_Missense_Mutation_p.R236W	NM_016327	NP_057411	Q9UBR1	BUP1_HUMAN	beta-ureidopropionase	236	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			ovary(2)	2	Colorectal(2;0.0339)					TTGCTACGGGCGGCACCACCC	0.562													26	64					0	0	0	0	T	24911253	T	T	24911253	3	4	214	1	0	0	0	0	1	0	0	0	17070	759	27	1	728	1	UPB1	22	24911253	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	824477	24911253	26393313	634	39524											
ZNRF3	84133	broad.mit.edu	37	chr22	29445929	29445929	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgggagctgctccaccttccGcagctccctcagcagcgact	6	7	10	18	3	1	0	1	0	0	0	4	2	4	1	4	1	5	5	4	1	0	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:29445929G>A	uc003aeg.2	+	8	1625	c.1460G>A	c.(1459-1461)CGC>CAC	p.R487H	ZNRF3_uc003aeh.1_Missense_Mutation_p.R487H	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	587	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						TCCACCTTCCGCAGCTCCCTC	0.637													32	109					0	0	0	0	A	29445929	A	A	29445929	3	1	214	1	0	0	0	0	1	0	0	0	18280	1087	38	1	1486	1	ZNRF3	22	29445929	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4534676	29445929	21858637	635	39525											
SMTN	6525	broad.mit.edu	37	chr22	31484020	31484020	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccgggaactgcagcggcagGagctggagcgcgaggaggag	9	3	20	9	4	0	0	0	0	0	0	1	6	1	5	1	6	5	3	1	6	1	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:31484020G>A	uc003ajl.1	+	3	339	c.121G>A	c.(121-123)GAG>AAG	p.E41K	SMTN_uc003ajk.1_Missense_Mutation_p.E41K|SMTN_uc003ajm.1_Missense_Mutation_p.E41K|SMTN_uc011ale.1_Missense_Mutation_p.E95K|SMTN_uc011alf.1_Missense_Mutation_p.E97K|SMTN_uc003ajn.1_Missense_Mutation_p.E33K|SMTN_uc011alg.1_5'Flank	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	41	Potential.				muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						GCAGCGGCAGGAGCTGGAGCG	0.652													6	28					0	0	0	0	A	31484020	A	A	31484020	3	1	214	1	0	0	0	0	1	0	0	0	14878	1175	41	2	127	2	SMTN	22	31484020	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2038091	31484020	19820546	636	39526											
RFPL2	10739	broad.mit.edu	37	chr22	32587230	32587230	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaacggacacgtcaaatctCtcggcaaggtcttgccgatt	11	9	9	12	4	3	0	1	0	2	0	5	2	3	1	1	3	2	1	1	3	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:32587230C>T	uc003amg.3	-	5	1602	c.666G>A	c.(664-666)GAG>GAA	p.E222E	RFPL2_uc003ame.3_Silent_p.E161E|RFPL2_uc003amf.3_Silent_p.E132E|RFPL2_uc003amh.3_Silent_p.E132E	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	222	B30.2/SPRY.						zinc ion binding			skin(1)	1						CGTCAAATCTCTCGGCAAGGT	0.582													8	95					0	0	0	0	T	32587230	T	T	32587230	2	4	214	1	0	0	0	0	0	0	0	1	13319	912	32	2		2	RFPL2	22	32587230	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1103210	32587230	18717336	637	39527											
MYH9	4627	broad.mit.edu	37	chr22	36691644	36691645	+	Missense_Mutation	DNP	TC	AT	AT																															caaggtcccgtttctgcttcTcagctttattcctggaagca																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:36691644_36691645TC>AT	uc003apg.2	-	26	3622_3623	c.3391_3392GA>AT	c.(3391-3393)GAG>ATG	p.E1131M		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1131	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TTTCTGCTTCTCAGCTTTATTC	0.55			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				7	37					0	0	0	0	AT	36691645	AT	AT	36691644	3	1	214	1	0	0	0	0	1	0	0	0	10095	1551	54	5	2554	5	MYH9	22	36691644	Missense_Mutation	DNP	TC	TCGA-CV-6961-01A-21D-1912-08	4104414	36691644	14612922	638	39528											
TRIOBP	11078	broad.mit.edu	37	chr22	38120212	38120212	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgcacgagacaaccccaCaacatcctgtgcccagcggg	11	4	10	16	2	0	1	0	0	0	1	1	2	1	1	4	1	6	2	4	1	2	0			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:38120212C>G	uc003atr.2	+	7	1920	c.1649C>G	c.(1648-1650)ACA>AGA	p.T550R	TRIOBP_uc003atu.2_Missense_Mutation_p.T378R|TRIOBP_uc003atq.1_Missense_Mutation_p.T550R|TRIOBP_uc003ats.1_Missense_Mutation_p.T378R	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	550					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GACAACCCCACAACATCCTGT	0.597													6	249					0	0	0	0	G	38120212	G	G	38120212	3	3	214	1	0	0	0	0	1	0	0	0	16620	478	17	4	1667	4	TRIOBP	22	38120212	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1428568	38120212	13184354	639	39529											
CBX7	23492	broad.mit.edu	37	chr22	39530549	39530549	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggggcgggaacttcttgcgcGagagccgcaggtacttgtgg	6	8	18	9	4	1	1	0	0	1	1	1	3	1	2	1	5	4	2	1	5	2	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:39530549G>C	uc003axb.2	-	5	544	c.455C>G	c.(454-456)TCG>TGG	p.S152W	CBX7_uc003axc.2_Intron	NM_175709	NP_783640	O95931	CBX7_HUMAN	chromobox homolog 7	152					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				ovary(1)	1	Melanoma(58;0.04)					CTTCTTGCGCGAGAGCCGCAG	0.701													6	20					0	0	0	0	C	39530549	C	C	39530549	3	2	214	1	0	0	0	0	1	0	0	0	2735	1059	37	3	308	3	CBX7	22	39530549	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1410337	39530549	11774017	640	39530											
ADSL	158	broad.mit.edu	37	chr22	40745953	40745953	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacgacatgatgtgatggctCacgtgcacacatttggccac	10	10	10	11	2	1	2	1	2	0	0	1	3	1	2	1	2	2	2	1	2	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:40745953C>G	uc003ayp.3	+	2	330	c.271C>G	c.(271-273)CAC>GAC	p.H91D	ADSL_uc003ays.3_Missense_Mutation_p.H91D|ADSL_uc003ayq.3_Missense_Mutation_p.H91D|ADSL_uc003ayr.3_5'UTR|ADSL_uc003ayt.3_Missense_Mutation_p.H91D	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	91					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1						TGTGATGGCTCACGTGCACAC	0.468													4	74					0	0	0	0	G	40745953	G	G	40745953	3	3	214	1	0	0	0	0	1	0	0	0	346	826	29	2	277	2	ADSL	22	40745953	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1215404	40745953	10558613	641	39531											
ZC3H7B	23264	broad.mit.edu	37	chr22	41738568	41738568	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaacactgccttgctcatCaagaaccccttggctgccac	9	8	6	18	0	2	1	2	0	0	1	2	1	2	1	5	1	5	2	5	1	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:41738568C>T	uc003azw.2	+	12	1449	c.1233C>T	c.(1231-1233)ATC>ATT	p.I411I	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	427					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						CCTTGCTCATCAAGAACCCCT	0.602													4	47					0	0	0	0	T	41738568	T	T	41738568	2	4	214	1	0	0	0	0	0	0	0	1	17640	816	29	2		2	ZC3H7B	22	41738568	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	992615	41738568	9565998	642	39532											
PACSIN2	11252	broad.mit.edu	37	chr22	43272287	43272287	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagaaggggttgttagactCatcgtctgaccagtcggtgg	8	10	16	7	2	2	3	1	1	1	2	4	4	2	3	1	5	0	2	1	5	2	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:43272287C>G	uc010gzg.2	-	10	1426	c.1204G>C	c.(1204-1206)GAG>CAG	p.E402Q	PACSIN2_uc003bdg.3_Missense_Mutation_p.E402Q|PACSIN2_uc003bde.3_Missense_Mutation_p.E402Q|PACSIN2_uc003bdf.3_Missense_Mutation_p.E361Q	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	402					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				TTGTTAGACTCATCGTCTGAC	0.617													14	51					0	0	0	0	G	43272287	G	G	43272287	3	3	214	1	0	0	0	0	1	0	0	0	11429	835	29	2	264	2	PACSIN2	22	43272287	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1533719	43272287	8032279	643	39533											
KIAA1644	85352	broad.mit.edu	37	chr22	44681333	44681334	+	Missense_Mutation	DNP	TC	AT	AT																															agacgaactctggaaggtcaTcagcggtgggctgtgagcat																										TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:44681333_44681334TC>AT	uc003bet.2	-	4	706_707	c.573_574GA>AT	c.(571-576)CTGATG>CTATTG	p.M192L		NM_001099294	NP_001092764	Q3SXP7	K1644_HUMAN	hypothetical protein LOC85352 precursor	192	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				TGGAAGGTCATCAGCGGTGGGC	0.609													19	71					0	0	0	0	AT	44681334	AT	AT	44681333	3	1	214	1	0	0	0	0	1	0	0	0	8289	1435	50	5	33	5	KIAA1644	22	44681333	Missense_Mutation	DNP	TC	TCGA-CV-6961-01A-21D-1912-08	1409046	44681333	6623233	644	39534											
KIAA1644	85352	broad.mit.edu	37	chr22	44681481	44681481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccgccgggggtcctgtttCatccatcgtccttggatgcc	4	11	11	15	3	1	0	1	0	0	0	5	1	4	1	6	3	1	1	6	3	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:44681481C>T	uc003bet.2	-	4	559	c.426G>A	c.(424-426)ATG>ATA	p.M142I		NM_001099294	NP_001092764	Q3SXP7	K1644_HUMAN	hypothetical protein LOC85352 precursor	142	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				GGTCCTGTTTCATCCATCGTC	0.652													36	95					0	0	0	0	T	44681481	T	T	44681481	3	4	214	1	0	0	0	0	1	0	0	0	8289	826	29	2	181	2	KIAA1644	22	44681481	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	148	44681481	6623085	645	39535											
GTSE1	51512	broad.mit.edu	37	chr22	46704811	46704811	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgagcggcctctgttagaGgaagaagcatccctggggct	8	8	14	11	2	1	2	0	0	1	2	3	4	2	3	2	4	2	3	2	4	3	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:46704811G>A	uc011aqy.1	+	4	945	c.733G>A	c.(733-735)GGA>AGA	p.G245R	GTSE1_uc011aqz.1_Missense_Mutation_p.G92R	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	226					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CTCTGTTAGAGGAAGAAGCAT	0.612													20	71					0	0	0	0	A	46704811	A	A	46704811	3	1	214	1	0	0	0	0	1	0	0	0	6924	1001	35	4	743	4	GTSE1	22	46704811	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	2023330	46704811	4599755	646	39536											
SELO	83642	broad.mit.edu	37	chr22	50654234	50654234	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcggaattcctggccaggctGatggagcagtgtgcctccct	6	9	14	12	1	0	1	0	1	0	0	2	3	2	3	4	4	2	2	4	4	1	1			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:50654234G>A	uc011arr.1	+	6	1498	c.1440G>A	c.(1438-1440)CTG>CTA	p.L480L	SELO_uc010hap.2_Silent_p.L291L|SELO_uc003bjy.2_Silent_p.L160L|SELO_uc003bjz.2_Missense_Mutation_p.D233N	NM_031454	NP_113642	Q9BVL4	SELO_HUMAN	selenoprotein O	480											0		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		TGGCCAGGCTGATGGAGCAGT	0.587													31	63					0	0	0	0	A	50654234	A	A	50654234	2	1	214	1	0	0	0	0	0	0	0	1	14083	1277	45	2		2	SELO	22	50654234	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3949423	50654234	650332	647	39537											
SAPS2	9701	broad.mit.edu	37	chr22	50845240	50845240	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaccatgagccgcctctcaAtcctctgctcgccagttttt	6	12	8	15	2	2	1	1	1	2	0	5	2	3	2	5	1	2	2	5	1	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chr22:50845240A>G	uc003blb.1	+	5	772	c.350A>G	c.(349-351)AAT>AGT	p.N117S	SAPS2_uc003bky.1_Missense_Mutation_p.N117S|SAPS2_uc003bkz.1_Missense_Mutation_p.N117S|SAPS2_uc003blc.2_Missense_Mutation_p.N117S|SAPS2_uc003bla.1_Missense_Mutation_p.N117S	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	117						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		CCGCCTCTCAATCCTCTGCTC	0.547													88	257					0	0	0	0	G	50845240	G	G	50845240	3	3	214	1	0	0	0	0	1	0	0	0	13902	101	4	5	356	5	SAPS2	22	50845240	Missense_Mutation	SNP	A	TCGA-CV-6961-01A-21D-1912-08	191006	50845240	459326	648	39538											
BMX	660	broad.mit.edu	37	chrX	15560113	15560113	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttatttccaggaaactcaGccatcccaagctggttaaat	12	12	7	10	0	1	0	1	0	0	0	3	1	3	1	3	2	3	3	3	2	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:15560113G>T	uc004cww.2	+	15	1591	c.1403G>T	c.(1402-1404)AGC>ATC	p.S468I	BMX_uc004cwx.3_Missense_Mutation_p.S468I|BMX_uc004cwy.3_Missense_Mutation_p.S468I	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	468	Protein kinase.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AGGAAACTCAGCCATCCCAAG	0.373													35	46					2.48696e-23	2.74966e-23	1	0	T	15560113	T	T	15560113	3	4	214	1	0	0	0	0	1	0	0	0	1476	971	34	4	1457	4	BMX	23	15560113	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08		15560113	139710447	649	39539											
DMD	1756	broad.mit.edu	37	chrX	32398771	32398771	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggacaatttcaagcatttCtccaactgttgctttctttc	8	16	6	11	1	3	0	1	0	2	0	5	1	3	1	1	1	3	3	1	1	3	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:32398771C>A	uc004dda.1	-	34	4945	c.4701G>T	c.(4699-4701)GAG>GAT	p.E1567D	DMD_uc004dcw.2_Missense_Mutation_p.E223D|DMD_uc004dcx.2_Missense_Mutation_p.E226D|DMD_uc004dcz.2_Missense_Mutation_p.E1444D|DMD_uc004dcy.1_Missense_Mutation_p.E1563D|DMD_uc004ddb.1_Missense_Mutation_p.E1559D|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1567	Spectrin 10.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCAAGCATTTCTCCAACTGTT	0.338													23	17					1.28384e-07	1.35641e-07	1	0	A	32398771	A	A	32398771	3	1	214	1	0	0	0	0	1	0	0	0	4602	912	32	2	6688	2	DMD	23	32398771	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	16838658	32398771	122871789	650	39540											
USP9X	8239	broad.mit.edu	37	chrX	41000592	41000592	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaagatgaatgcactgaatGaagttaataaggtgatatct	17	11	10	3	0	1	5	0	4	1	1	1	6	1	5	0	1	1	2	0	1	7	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:41000592G>A	uc004dfb.2	+	9	1702	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K	USP9X_uc004dfc.2_Missense_Mutation_p.E357K	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	357					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TGCACTGAATGAAGTTAATAA	0.348													10	5					0	0	0	0	A	41000592	A	A	41000592	3	1	214	1	0	0	0	0	1	0	0	0	17158	1291	45	2	1099	2	USP9X	23	41000592	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	8601821	41000592	114269968	651	39541											
SLC9A7	84679	broad.mit.edu	37	chrX	46472745	46472745	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgtacacctggggactggtCagacatcgagctagtaagcc	10	8	12	11	2	1	1	1	0	0	1	3	3	1	2	2	3	3	3	2	3	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:46472745C>G	uc004dgu.1	-	16	1913	c.1905G>C	c.(1903-1905)CTG>CTC	p.L635L		NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	635					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						GGGGACTGGTCAGACATCGAG	0.512													19	27					0	0	0	0	G	46472745	G	G	46472745	2	3	214	1	0	0	0	0	0	0	0	1	14783	813	29	2		2	SLC9A7	23	46472745	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	5472153	46472745	108797815	652	39542											
CFP	5199	broad.mit.edu	37	chrX	47485839	47485839	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgcgtgactgctggcccggGatttcttgacagctgatgga	6	10	14	11	3	1	3	0	3	1	0	1	5	1	5	2	3	2	2	2	3	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:47485839G>A	uc004dig.3	-	7	1146	c.1020C>T	c.(1018-1020)ATC>ATT	p.I340I	CFP_uc004dih.2_Silent_p.I340I|CFP_uc004dii.1_Silent_p.I276I|CFP_uc010nhu.2_Silent_p.I340I	NM_001145252	NP_001138724	P27918	PROP_HUMAN	complement factor properdin precursor	340	TSP type-1 5.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3						GCTGGCCCGGGATTTCTTGAC	0.617													15	10					0	0	0	0	A	47485839	A	A	47485839	2	1	214	1	0	0	0	0	0	0	0	1	3308	1164	41	2		2	CFP	23	47485839	Silent	SNP	G	TCGA-CV-6961-01A-21D-1912-08	1013094	47485839	107784721	653	39543											
CACNA1F	778	broad.mit.edu	37	chrX	49076130	49076130	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagaagaaggcgctgccctCagggatgggtaccaccttct	9	7	13	12	1	2	2	1	0	1	2	2	3	2	3	3	3	2	3	3	3	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:49076130C>T	uc004dnb.2	-	20	2601	c.2539G>A	c.(2539-2541)GAG>AAG	p.E847K	CACNA1F_uc010nip.2_Missense_Mutation_p.E836K	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	847	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GCGCTGCCCTCAGGGATGGGT	0.512													3	3					0	0	0	0	T	49076130	T	T	49076130	3	4	214	1	0	0	0	0	1	0	0	0	2555	835	29	2	3510	2	CACNA1F	23	49076130	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1590291	49076130	106194430	654	39544											
AKAP4	8852	broad.mit.edu	37	chrX	49958507	49958507	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcctctccagtgccacgcAtttctgcagctgtcagttcc	6	12	7	16	1	3	0	1	0	2	0	6	0	5	0	4	0	3	4	4	0	0	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:49958507A>G	uc004dow.1	-	5	981	c.857T>C	c.(856-858)ATG>ACG	p.M286T	AKAP4_uc004dov.1_Intron|AKAP4_uc010njp.1_Missense_Mutation_p.M108T|AKAP4_uc004dou.1_Missense_Mutation_p.M277T	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	286					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					AGTGCCACGCATTTCTGCAGC	0.498													15	21					0	0	0	0	G	49958507	G	G	49958507	3	3	214	1	0	0	0	0	1	0	0	0	453	217	8	5	1715	5	AKAP4	23	49958507	Missense_Mutation	SNP	A	TCGA-CV-6961-01A-21D-1912-08	882377	49958507	105312053	655	39545											
HUWE1	10075	broad.mit.edu	37	chrX	53602642	53602642	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcgtatcaaagtcactgctCtgacgcgtaagtgaccggta	10	10	11	10	4	3	2	2	2	1	0	3	2	3	2	1	1	2	4	1	1	4	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:53602642C>G	uc004dsp.2	-	45	6393	c.5991G>C	c.(5989-5991)CAG>CAC	p.Q1997H	HUWE1_uc004dsn.2_Missense_Mutation_p.Q821H	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1997					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGTCACTGCTCTGACGCGTAA	0.448													6	7					0	0	0	0	G	53602642	G	G	53602642	3	3	214	1	0	0	0	0	1	0	0	0	7500	912	32	2	7293	2	HUWE1	23	53602642	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3644135	53602642	101667918	656	39546											
ZMYM3	9203	broad.mit.edu	37	chrX	70470284	70470284	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaagaccctcacgcacttCttgcagaaggtacaggtctt	10	9	8	14	1	3	2	1	0	2	2	3	2	3	2	2	2	2	3	2	2	3	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ea8183de-8f9b-4d30-a23b-c6ffc183f22b	g.chrX:70470284C>T	uc004dzh.1	-	5	1158	c.1071G>A	c.(1069-1071)AAG>AAA	p.K357K	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.K357K|ZMYM3_uc004dzj.1_Silent_p.K357K|ZMYM3_uc011mpu.1_Silent_p.K88K|ZMYM3_uc004dzk.3_Silent_p.K357K|ZMYM3_uc004dzl.3_Silent_p.K357K|ZMYM3_uc004dzm.3_Silent_p.K357K	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	357	MYM-type 1.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TCACGCACTTCTTGCAGAAGG	0.557													4	2					0	0	0	0	T	70470284	T	T	70470284	2	4	214	1	0	0	0	0	0	0	0	1	17768	912	32	2		2	ZMYM3	23	70470284	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	16867642	70470284	84800276	657	39547											
PIN4	5303	broad.mit.edu	37	chrX	71401627	71401627	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggttcagcgttcaacaacaaGcttccaagatgccgcccaaa	13	7	8	13	2	2	1	2	0	0	1	3	1	3	1	3	1	5	3	3	1	5	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:71401627G>A	uc004eam.2	+	1	102	c.67G>A	c.(67-69)GCT>ACT	p.A23T	PIN4_uc004eao.1_Missense_Mutation_p.A23T	NM_006223	NP_006214	Q9Y237	PIN4_HUMAN	protein (peptidyl-prolyl cis/trans isomerase)	Error:Variant_position_missing_in_Q9Y237_after_alignment					protein folding|rRNA processing	cytoplasm|mitochondrial matrix|mitochondrial matrix|nucleolus|nucleolus|preribosome|spindle|spindle	bent DNA binding|DNA binding|double-stranded DNA binding|peptidyl-prolyl cis-trans isomerase activity				0	Renal(35;0.156)					TCAACAACAAGCTTCCAAGAT	0.547													5	11					0	0	0	0	A	71401627	A	A	71401627	3	1	214	1	0	0	0	0	1	0	0	0	11986	971	34	4	69	4	PIN4	23	71401627	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	931343	71401627	83868933	658	39548											
UPRT	139596	broad.mit.edu	37	chrX	74519710	74519710	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatttaccggagaaaagtcCttctgatgtatccaattctc	12	13	6	10	1	2	2	0	1	2	1	5	3	4	2	3	1	1	1	3	1	5	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:74519710C>A	uc004ecb.1	+	5	832	c.703C>A	c.(703-705)CTT>ATT	p.L235I	UPRT_uc004ecc.1_RNA|UPRT_uc004ecd.1_Missense_Mutation_p.L235I|UPRT_uc004ece.1_Missense_Mutation_p.L99I	NM_145052	NP_659489	Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog	235					nucleoside metabolic process	cytoplasm|nucleus					0						GAGAAAAGTCCTTCTGATGTA	0.413													37	23					5.04308e-16	5.52136e-16	1	0	A	74519710	A	A	74519710	3	1	214	1	0	0	0	0	1	0	0	0	17082	681	24	4	721	4	UPRT	23	74519710	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	3118083	74519710	80750850	659	39549											
TAF7L	54457	broad.mit.edu	37	chrX	100532640	100532640	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgctcattcccgaggatatCaaaaatcctgggatggagcc	11	9	10	11	1	2	0	2	0	0	0	4	4	4	3	3	3	2	1	3	3	3	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:100532640C>G	uc004ehb.2	-	9	915	c.903G>C	c.(901-903)TTG>TTC	p.L301F	TAF7L_uc004eha.2_Missense_Mutation_p.L215F|TAF7L_uc004ehc.1_Missense_Mutation_p.L215F	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	301					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						CCGAGGATATCAAAAATCCTG	0.468													20	97					0	0	0	0	G	100532640	G	G	100532640	3	3	214	1	0	0	0	0	1	0	0	0	15599	825	29	2	505	2	TAF7L	23	100532640	Missense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	26012930	100532640	54737920	660	39550											
SLC6A14	11254	broad.mit.edu	37	chrX	115585606	115585606	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtctcgtctgtgtgactCaggtatactacagcattttt	7	17	9	8	1	3	1	1	1	2	0	4	1	3	1	0	2	3	2	0	2	3	6			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:115585606C>T	uc004eqi.2	+	10	1506	c.1402C>T	c.(1402-1404)CAG>TAG	p.Q468*		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	468	Helical; Name=9; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	CTGTGTGACTCAGGTATACTA	0.358													17	21					0	0	0	0	T	115585606	T	T	115585606	4	4	214	1	0	0	0	0	0	1	0	0	14741	827	29	2	1440	2	SLC6A14	23	115585606	Nonsense_Mutation	SNP	C	TCGA-CV-6961-01A-21D-1912-08	15052966	115585606	39684954	661	39551											
MCTS1	28985	broad.mit.edu	37	chrX	119738100	119738100	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaccttggatcatgttcaaGaagtaaggacatgctgtggc	11	11	11	8	0	3	1	3	0	0	1	3	3	3	3	1	3	1	3	1	3	3	3			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:119738100G>C	uc004esx.2	+	1	357	c.9G>C	c.(7-9)AAG>AAC	p.K3N	MCTS1_uc011mub.1_5'Flank	NM_014060	NP_054779	Q9ULC4	MCTS1_HUMAN	malignant T cell amplified sequence 1 isoform 1	3					cell cycle|positive regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm	RNA binding				0						TCATGTTCAAGAAGTAAGGAC	0.582													8	24					0	0	0	0	C	119738100	C	C	119738100	3	2	214	1	0	0	0	0	1	0	0	0	9455	933	33	2	11	2	MCTS1	23	119738100	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	4152494	119738100	35532460	662	39552											
THOC2	57187	broad.mit.edu	37	chrX	122866817	122866817	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcacaattcgcctctccctGatttctcccagttctttatc	6	16	3	16	1	4	1	1	1	3	0	8	1	4	1	3	0	0	1	3	0	2	5			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:122866817G>A	uc004etu.2	-	1	88	c.56C>T	c.(55-57)TCA>TTA	p.S19L	THOC2_uc011mui.1_5'UTR	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	19					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						GCCTCTCCCTGATTTCTCCCA	0.632											OREG0003979|OREG0003978	type=REGULATORY REGION|Gene=THOC2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|Gene=BC041435|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	37					0	0	0	0	A	122866817	A	A	122866817	3	1	214	1	0	0	0	0	1	0	0	0	15931	1294	45	2	4877	2	THOC2	23	122866817	Missense_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	3128717	122866817	32403743	663	39553											
MAGEA6	4105	broad.mit.edu	37	chrX	151870254	151870254	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgagagagggggaagagtGagtctgagcacgagttgcag	11	8	18	4	1	1	5	0	3	1	2	1	8	1	6	0	2	2	3	0	2	1	2			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:151870254G>C	uc004ffq.1	+	3	1138	c.944G>C	c.(943-945)TGA>TCA	p.*315S	MAGEA6_uc004ffr.1_Nonstop_Mutation_p.*315S|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	315							protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					GGGGAAGAGTGAGTCTGAGCA	0.577													29	60					0	0	0	0	C	151870254	C	C	151870254	4	2	214	1	0	0	0	0	0	0	0	0	9221	1285	45	2	946	2	MAGEA6	23	151870254	Nonstop_Mutation	SNP	G	TCGA-CV-6961-01A-21D-1912-08	29003437	151870254	3400306	664	39554											
G6PD	2539	broad.mit.edu	37	chrX	153760233	153760233	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcagagcttgtgggggttCacccacttgtaggtgccctc	5	11	13	12	0	2	1	2	0	0	1	3	1	2	1	2	3	2	4	2	3	1	4			TCGA-CV-6961-01A-21D-1912-08	TCGA-CV-6961-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	92d3315c-179c-47f6-b61e-9945f6988e1c	ecfc9472-89ce-448e-88a2-a55357fc481f	g.chrX:153760233C>A	uc004fly.1	-	13	1643	c.1530G>T	c.(1528-1530)GTG>GTT	p.V510V	G6PD_uc004flx.1_Silent_p.V540V	NM_001042351	NP_001035810	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase isoform b	510					cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			ovary(4)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGTGGGGGTTCACCCACTTGT	0.677													7	9					8.12818e-05	8.40662e-05	1	0	A	153760233	A	A	153760233	2	1	214	1	0	0	0	0	0	0	0	1	6180	813	29	2		2	G6PD	23	153760233	Silent	SNP	C	TCGA-CV-6961-01A-21D-1912-08	1889979	153760233	1510327	665	39555											
VPS13D	55187	broad.mit.edu	37	chr1	12304644	12304644	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtattcagttaccgcctcCgtagttacaaggattgtgga	9	13	11	8	2	1	0	1	0	0	0	2	2	2	2	3	3	2	4	3	3	5	6	rs34489138	byFrequency	TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:12304644C>A	uc001atv.2	+	5	558	c.417C>A	c.(415-417)TCC>TCA	p.S139S	VPS13D_uc001atw.2_Silent_p.S139S	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	139					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTACCGCCTCCGTAGTTACAA	0.413													35	19					2.32173e-10	2.65145e-10	1	0	A	12304644	A	A	12304644	2	1	215	1	0	0	0	0	0	0	0	1	17260	639	23	3		3	VPS13D	1	12304644	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08		12304644	236945977	1	39556											
PLEKHM2	23207	broad.mit.edu	37	chr1	16058487	16058487	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctggagctaagtgccgagAgcgaggccgagatggccgag	9	4	18	10	4	0	2	0	0	0	2	0	7	0	3	4	3	3	1	4	3	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:16058487A>G	uc010obo.1	+	17	2796	c.2569A>G	c.(2569-2571)AGC>GGC	p.S857G		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	857	Interaction with sifA.|PH.				Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AAGTGCCGAGAGCGAGGCCGA	0.667													10	8					0	0	0	0	G	16058487	G	G	16058487	3	3	215	1	0	0	0	0	1	0	0	0	12136	304	11	5	2635	5	PLEKHM2	1	16058487	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	3753843	16058487	233192134	2	39557											
PADI4	23569	broad.mit.edu	37	chr1	17668883	17668883	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacacccagcccccgcaggaGgtgtacgcgtgcaggtgaga	10	4	14	13	3	0	1	0	1	0	1	0	3	0	2	3	3	4	3	3	3	2	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:17668883G>A	uc001baj.2	+	8	949	c.921G>A	c.(919-921)GAG>GAA	p.E307E	PADI4_uc009vpc.2_Silent_p.E307E	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	307					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CCCCGCAGGAGGTGTACGCGT	0.632													15	7					0	0	0	0	A	17668883	A	A	17668883	2	1	215	1	0	0	0	0	0	0	0	1	11434	991	35	4		4	PADI4	1	17668883	Silent	SNP	G	TCGA-CV-6962-01A-11D-1912-08	1610396	17668883	231581738	3	39558											
JAK1	3716	broad.mit.edu	37	chr1	65301898	65301898	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attaaacattctggagcataCcttgaaaggaagcagaacac	17	8	8	8	0	1	2	0	1	1	1	1	4	1	4	1	2	5	2	1	2	6	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:65301898C>T	uc001dbu.1	-	23	3390	c.3141G>A	c.(3139-3141)TGG>TGA	p.W1047*	JAK1_uc009wam.1_Nonsense_Mutation_p.W1035*|JAK1_uc009wal.1_Nonsense_Mutation_p.W224*	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	1047	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity	p.W1047G(1)		haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		CTGGAGCATACCTTGAAAGGA	0.403			Mis		ALL								15	6					0	0	0	0	T	65301898	T	T	65301898	4	4	215	1	0	0	0	0	0	1	0	0	7976	521	18	4	335	4	JAK1	1	65301898	Nonsense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	47633015	65301898	183948723	4	39559											
FAM102B	284611	broad.mit.edu	37	chr1	109170788	109170788	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatgttatgacatattacaGatctttcagcaaagagtgcc	13	13	7	8	0	3	3	2	1	1	2	3	3	3	3	1	0	3	2	1	0	4	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:109170788G>C	uc010ouy.1	+	7	637	c.557_splice	c.e7-1	p.D186_splice		NM_001010883	NP_001010883	Q5T8I3	F102B_HUMAN	hypothetical protein LOC284611											large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		ACATATTACAGATCTTTCAGC	0.378													25	10					0	0	0	0	C	109170788	C	C	109170788	5	2	215	1	0	0	0	0	0	0	1	0	5411	956	33	2	582	2	FAM102B	1	109170788	Splice_Site	SNP	G	TCGA-CV-6962-01A-11D-1912-08	43868890	109170788	140079833	5	39560											
PROK1	84432	broad.mit.edu	37	chr1	110996644	110996644	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccatcagcctgtggcttcGagggctgcggatgtgcaccc	5	9	14	13	2	1	0	1	0	0	0	2	2	1	1	3	3	4	3	3	3	0	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:110996644G>A	uc001dzs.2	+	2	185	c.134G>A	c.(133-135)CGA>CAA	p.R45Q		NM_032414	NP_115790	P58294	PROK1_HUMAN	prokineticin 1 precursor	45					angiogenesis|positive regulation of cell division	extracellular region	growth factor activity				0		all_cancers(81;6.23e-06)|all_epithelial(167;2.12e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0239)|all cancers(265;0.0699)|Epithelial(280;0.0753)|Colorectal(144;0.105)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTGTGGCTTCGAGGGCTGCGG	0.622													24	14					0	0	0	0	A	110996644	A	A	110996644	3	1	215	1	0	0	0	0	1	0	0	0	12612	1058	37	1	140	1	PROK1	1	110996644	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	1825856	110996644	138253977	6	39561											
ZNF687	57592	broad.mit.edu	37	chr1	151259689	151259690	+	Missense_Mutation	DNP	GG	TT	TT																															gtccccagagtccctctagtGgggccgaggctgcagatgag																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:151259689_151259690GG>TT	uc001exq.2	+	2	1020_1021	c.922_923GG>TT	c.(922-924)GGG>TTG	p.G308L	ZNF687_uc001exp.1_Missense_Mutation_p.G317L|ZNF687_uc009wmo.2_Missense_Mutation_p.G308L|ZNF687_uc009wmp.2_Missense_Mutation_p.G308L	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	308					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCCCTCTAGTGGGGCCGAGGCT	0.569													29	42					0	0	0	0	TT	151259690	TT	TT	151259689	3	4	215	1	0	0	0	0	1	0	0	0	18159	1348	47	4	924	4	ZNF687	1	151259689	Missense_Mutation	DNP	GG	TCGA-CV-6962-01A-11D-1912-08	40263045	151259689	97990932	7	39562											
THEM5	284486	broad.mit.edu	37	chr1	151820766	151820766	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccagggacccgccgtgagcaAacctgggggtggggtaaggt	8	5	18	10	2	0	1	0	1	0	0	0	2	0	2	4	6	2	2	4	6	2	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:151820766A>C	uc009wnd.2	-	4	599	c.467T>G	c.(466-468)TTT>TGT	p.F156C		NM_182578	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	156							hydrolase activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCCGTGAGCAAACCTGGGGGT	0.602													13	26					0	0	0	0	C	151820766	C	C	151820766	3	2	215	1	0	0	0	0	1	0	0	0	15925	14	1	5	288	5	THEM5	1	151820766	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	561077	151820766	97429855	8	39563											
HSPA6	3310	broad.mit.edu	37	chr1	161495385	161495385	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgtgctcagacctcttcCgcagcaccctggagccggtg	7	8	11	15	2	2	1	1	0	1	1	3	2	3	2	4	2	4	3	4	2	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:161495385C>T	uc001gap.2	+	2	1597	c.937C>T	c.(937-939)CGC>TGC	p.R313C	HSPA6_uc001gaq.2_Missense_Mutation_p.R313C	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	313					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGACCTCTTCCGCAGCACCCT	0.632													5	30					0	0	0	0	T	161495385	T	T	161495385	3	4	215	1	0	0	0	0	1	0	0	0	7454	652	23	1	939	1	HSPA6	1	161495385	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	9674619	161495385	87755236	9	39564											
ADCY10	55811	broad.mit.edu	37	chr1	167865864	167865864	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagaaggataataatgcatGaaggtcgtacactttgtgaa	15	10	10	6	1	0	3	0	2	0	1	1	4	0	4	1	2	2	2	1	2	6	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:167865864G>A	uc001ger.2	-	7	1006	c.708C>T	c.(706-708)TTC>TTT	p.F236F	ADCY10_uc009wvk.2_Silent_p.F144F|ADCY10_uc010plj.1_Silent_p.F83F|ADCY10_uc009wvl.2_Silent_p.F235F|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	236					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						AATAATGCATGAAGGTCGTAC	0.368													57	281					0	0	0	0	A	167865864	A	A	167865864	2	1	215	1	0	0	0	0	0	0	0	1	293	1281	45	2		2	ADCY10	1	167865864	Silent	SNP	G	TCGA-CV-6962-01A-11D-1912-08	6370479	167865864	81384757	10	39565											
PRRX1	5396	broad.mit.edu	37	chr1	170695536	170695536	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgggggacagcgtctcCgtacaggtgaatgactggcc	7	8	14	12	2	1	2	0	2	1	0	3	3	2	3	3	4	2	1	3	4	2	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:170695536C>G	uc001ghf.2	+	3	640	c.593C>G	c.(592-594)CCG>CGG	p.P198R	PRRX1_uc001ghe.2_Missense_Mutation_p.P198R	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	198						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ACAGCGTCTCCGTACAGGTGA	0.562													25	37					0	0	0	0	G	170695536	G	G	170695536	3	3	215	1	0	0	0	0	1	0	0	0	12674	652	23	3	603	3	PRRX1	1	170695536	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	2829672	170695536	78555085	11	39566											
KIF21B	23046	broad.mit.edu	37	chr1	200967679	200967679	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgatctcacaagtcaggtcgGccaggtccgcctggaagttc	8	8	12	13	3	2	0	2	0	1	0	6	2	3	1	3	4	0	1	3	4	2	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:200967679G>A	uc001gvs.1	-	14	2227	c.1910C>T	c.(1909-1911)GCC>GTC	p.A637V	KIF21B_uc001gvr.1_Missense_Mutation_p.A637V|KIF21B_uc009wzl.1_Missense_Mutation_p.A637V|KIF21B_uc010ppn.1_Missense_Mutation_p.A637V	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	637	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						AGTCAGGTCGGCCAGGTCCGC	0.587													31	44					0	0	0	0	A	200967679	A	A	200967679	3	1	215	1	0	0	0	0	1	0	0	0	8328	1203	42	4	3048	4	KIF21B	1	200967679	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	30272143	200967679	48282942	12	39567											
PLXNA2	5362	broad.mit.edu	37	chr1	208216455	208216455	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgatgcccgggaacaggactCgcatagcgtaggtacgatag	11	6	14	10	5	0	0	0	0	0	0	1	4	0	2	1	3	4	3	1	3	5	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:208216455C>T	uc001hgz.2	-	21	4726	c.3968G>A	c.(3967-3969)CGA>CAA	p.R1323Q		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1323	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GAACAGGACTCGCATAGCGTA	0.607													29	32					0	0	0	0	T	208216455	T	T	208216455	3	4	215	1	0	0	0	0	1	0	0	0	12175	884	31	1	1764	1	PLXNA2	1	208216455	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	7248776	208216455	41034166	13	39568											
SPATA17	128153	broad.mit.edu	37	chr1	217955658	217955658	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggctgcaaaatgtaaatgAcaatatgtgagttcttagct	14	13	9	5	0	1	2	0	2	1	0	1	2	1	2	0	1	2	5	0	1	7	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:217955658A>G	uc001hlh.1	+	8	892	c.866A>G	c.(865-867)GAC>GGC	p.D289G	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.D289G	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	289						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		AATGTAAATGACAATATGTGA	0.363													15	27					0	0	0	0	G	217955658	G	G	217955658	3	3	215	1	0	0	0	0	1	0	0	0	15068	275	10	5	896	5	SPATA17	1	217955658	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	9739203	217955658	31294963	14	39569											
ACBD3	64746	broad.mit.edu	37	chr1	226340302	226340302	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtccacatggatggagctGctattactggaagagattct	10	12	12	7	0	1	1	0	0	1	1	2	5	2	4	1	3	3	2	1	3	3	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:226340302G>C	uc001hpy.2	-	7	1156	c.1109C>G	c.(1108-1110)GCA>GGA	p.A370G		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	370					steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		GGATGGAGCTGCTATTACTGG	0.448													76	139					0	0	0	0	C	226340302	C	C	226340302	3	2	215	1	0	0	0	0	1	0	0	0	123	1319	46	4	485	4	ACBD3	1	226340302	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	8384644	226340302	22910319	15	39570											
CABC1	56997	broad.mit.edu	37	chr1	227152980	227152993	+	Frame_Shift_Del	DEL	TTCTCTGCCATGGG	-	-																															ttgcaaaccccagagactcaTtctctgccatgggctttcag																								rs147812454		TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:227152980_227152993delTTCTCTGCCATGGG	uc001hqm.1	+	8	3876_3889	c.457_470delTTCTCTGCCATGGG	c.(457-471)TTCTCTGCCATGGGCfs	p.F153fs	CABC1_uc010pvp.1_Frame_Shift_Del_p.F116fs|CABC1_uc001hqn.1_Frame_Shift_Del_p.F153fs|CABC1_uc009xeq.1_Frame_Shift_Del_p.F101fs|CABC1_uc010pvq.1_Intron|CABC1_uc010pvr.1_5'Flank	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	153_157					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				CAGAGACTCATTCTCTGCCATGGGCTTTCAGCGA	0.636													---	---	---								-	227152993	-	-	227152980	7	5	215	1	0	1	0	1	0	0	0	0	2539	1493	52	0	463	0	CABC1	1	227152980	Frame_Shift_Del	DEL	TTCTCTGCCATGGG	TCGA-CV-6962-01A-11D-1912-08	812678	227152980	22097641	16	39571											
NUP133	55746	broad.mit.edu	37	chr1	229625736	229625736	+	Frame_Shift_Del	DEL	G	-	-																															tatattgagtgacttctacaGtaactgcatctgacatttgg																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:229625736delG	uc001htn.2	-	9	1252	c.1160delC	c.(1159-1161)ACTfs	p.T387fs		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	387					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				GACTTCTACAGTAACTGCATC	0.348													---	---	---								-	229625736	-	-	229625736	7	5	215	1	0	1	0	1	0	0	0	0	10808	1029	36	0	2382	0	NUP133	1	229625736	Frame_Shift_Del	DEL	G	TCGA-CV-6962-01A-11D-1912-08	2472756	229625736	19624885	17	39572											
OR2L2	26246	broad.mit.edu	37	chr1	248202502	248202502	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaaaatcttctcagtgaaAatgtagacatacgttctgtg	14	12	8	7	1	3	3	1	1	3	2	4	3	3	3	0	0	1	2	0	0	6	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr1:248202502A>C	uc001idw.2	+	1	1029	c.933A>C	c.(931-933)AAA>AAC	p.K311N	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TCTCAGTGAAAATGTAGACAT	0.443													7	69					0	0	0	0	C	248202502	C	C	248202502	3	2	215	1	0	0	0	0	1	0	0	0	11061	11	1	5	935	5	OR2L2	1	248202502	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	18576766	248202502	1048119	18	39573											
C2orf39	92749	broad.mit.edu	37	chr2	26654844	26654844	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattgcgaagaatacaacatGatcaagatcaagctggagca	17	7	10	7	1	2	3	2	1	0	2	2	6	2	4	0	1	5	2	0	1	6	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr2:26654844G>T	uc002rhg.2	+	7	932	c.858G>T	c.(856-858)ATG>ATT	p.M286I	C2orf39_uc010eym.1_RNA	NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	286	Potential.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATACAACATGATCAAGATCA	0.498													34	43					2.85442e-18	3.37977e-18	1	0	T	26654844	T	T	26654844	3	4	215	1	0	0	0	0	1	0	0	0	2174	1290	45	2	884	2	C2orf39	2	26654844	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08		26654844	216544529	19	39574											
LTBP1	4052	broad.mit.edu	37	chr2	33482371	33482371	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcttttaaggaaatctgtCctggtggaatgggttatacg	9	14	12	6	1	1	0	0	0	1	0	2	2	2	2	1	4	2	2	1	4	5	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr2:33482371C>A	uc002ros.2	+	12	2188	c.2188C>A	c.(2188-2190)CCT>ACT	p.P730T	LTBP1_uc002rot.2_Missense_Mutation_p.P404T|LTBP1_uc002rou.2_Missense_Mutation_p.P404T|LTBP1_uc002rov.2_Intron|LTBP1_uc010ymz.1_Missense_Mutation_p.P404T|LTBP1_uc010yna.1_Intron	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	730					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GGAAATCTGTCCTGGTGGAAT	0.393													29	39					5.97227e-30	7.63343e-30	1	0	A	33482371	A	A	33482371	3	1	215	1	0	0	0	0	1	0	0	0	9123	855	30	2	2289	2	LTBP1	2	33482371	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	6827527	33482371	209717002	20	39575											
ZFP36L2	678	broad.mit.edu	37	chr2	43452544	43452545	+	Frame_Shift_Ins	INS	-	T	T																															gctgctgcaggtgcaggaggINStgctggctgcgatcgccgtt																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr2:43452544_43452545insT	uc002rsv.3	-	2	689_690	c.398_399insA	c.(397-399)CACfs	p.H133fs	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	133					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GGTGCAGGAGGTGCTGGCTGCG	0.658													---	---	---								T	43452545	T	T	43452544	7	5	215	1	0	1	1	0	0	0	0	0	17714	1252	44	0	1089	0	ZFP36L2	2	43452544	Frame_Shift_Ins	INS	-	TCGA-CV-6962-01A-11D-1912-08	9970173	43452544	199746829	21	39576											
AFF3	3899	broad.mit.edu	37	chr2	100368683	100368683	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagggatgcaagatctcacCttatttggaaatggaaattt	13	13	10	5	0	1	2	1	1	1	1	2	5	1	5	1	3	1	1	1	3	4	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr2:100368683C>A	uc002tag.2	-	8	1238	c.1002G>T	c.(1000-1002)AAG>AAT	p.K334N	AFF3_uc002taf.2_Missense_Mutation_p.K359N|AFF3_uc010fiq.1_Missense_Mutation_p.K334N|AFF3_uc010yvr.1_Missense_Mutation_p.K488N|AFF3_uc002tah.1_Missense_Mutation_p.K359N|AFF3_uc010fir.1_Missense_Mutation_p.K411N	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	334					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						AAGATCTCACCTTATTTGGAA	0.443													20	44					8.10497e-08	8.99e-08	1	0	A	100368683	A	A	100368683	3	1	215	1	0	0	0	0	1	0	0	0	358	695	24	4	2746	4	AFF3	2	100368683	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	56916139	100368683	142830690	22	39577											
LRP1B	53353	broad.mit.edu	37	chr2	141359067	141359067	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggatggtcatcttctgacAtggtgatgacagcttccctg	7	13	12	9	0	3	3	1	3	2	0	4	4	4	4	1	3	1	1	1	3	0	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr2:141359067A>T	uc002tvj.1	-	42	7913	c.6941T>A	c.(6940-6942)ATG>AAG	p.M2314K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2314	Extracellular (Potential).|LDL-receptor class B 24.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATCTTCTGACATGGTGATGAC	0.428										TSP Lung(27;0.18)			13	36					0	0	0	0	T	141359067	T	T	141359067	3	4	215	1	0	0	0	0	1	0	0	0	9005	217	8	5	7058	5	LRP1B	2	141359067	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	40990384	141359067	101840306	23	39578											
PKP4	8502	broad.mit.edu	37	chr2	159519912	159519912	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccaacccagccaccttggaAggctctgcagggtctctcca	8	8	9	16	0	2	0	0	0	2	0	5	1	4	1	5	3	3	2	5	3	2	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr2:159519912A>T	uc002tzv.2	+	15	2792	c.2532A>T	c.(2530-2532)GAA>GAT	p.E844D	PKP4_uc002tzu.2_Missense_Mutation_p.E844D|PKP4_uc002tzw.2_Missense_Mutation_p.E844D|PKP4_uc002tzx.2_Missense_Mutation_p.E501D|PKP4_uc002uaa.2_Missense_Mutation_p.E696D|uc002uab.1_Intron|PKP4_uc002uac.2_Missense_Mutation_p.E25D	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	844	ARM 7.				cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						CCACCTTGGAAGGCTCTGCAG	0.493										HNSCC(62;0.18)			34	54					0	0	0	0	T	159519912	T	T	159519912	3	4	215	1	0	0	0	0	1	0	0	0	12042	69	3	5	2586	5	PKP4	2	159519912	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	18160845	159519912	83679461	24	39579											
TTN	7273	broad.mit.edu	37	chr2	179581995	179581995	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctcggttatctttggccCaagtgattttgattggtgca	6	17	10	8	1	2	2	0	2	2	0	4	2	2	2	1	3	1	2	1	3	2	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr2:179581995C>A	uc010zfg.1	-	85	21958	c.21734G>T	c.(21733-21735)TGG>TTG	p.W7245L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.W3906L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8172							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTTTGGCCCAAGTGATTTT	0.428													34	37					4.3181e-19	5.17635e-19	1	0	A	179581995	A	A	179581995	3	1	215	1	0	0	0	0	1	0	0	0	16803	595	21	4	79163	4	TTN	2	179581995	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	20062083	179581995	63617378	25	39580											
SRGAP3	9901	broad.mit.edu	37	chr3	9055160	9055160	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggatgtgcatgagggtaggcCcgaagcagatggccaggttg	9	7	18	7	1	0	2	0	1	0	1	0	4	0	3	2	5	2	4	2	5	2	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr3:9055160C>A	uc003brf.1	-	17	2655	c.1979G>T	c.(1978-1980)GGG>GTG	p.G660V	SRGAP3_uc003brg.1_Missense_Mutation_p.G636V	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	660	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GAGGGTAGGCCCGAAGCAGAT	0.527			T	RAF1	pilocytic astrocytoma								8	36					5.18039e-06	5.64868e-06	1	0	A	9055160	A	A	9055160	3	1	215	1	0	0	0	0	1	0	0	0	15213	623	22	4	1344	4	SRGAP3	3	9055160	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08		9055160	188967270	26	39581											
TRANK1	9881	broad.mit.edu	37	chr3	36873305	36873305	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccttgactcaatctccCggaagtggcgatacaggaga	11	7	12	11	2	2	2	1	1	1	1	3	5	2	3	2	3	2	1	2	3	3	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr3:36873305C>A	uc003cgj.2	-	12	6289	c.5987G>T	c.(5986-5988)CGG>CTG	p.R1996L		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2546					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CTCAATCTCCCGGAAGTGGCG	0.582													38	10					1.36161e-19	1.64245e-19	1	0	A	36873305	A	A	36873305	3	1	215	1	0	0	0	0	1	0	0	0	16521	652	23	3	1152	3	TRANK1	3	36873305	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	27818145	36873305	161149125	27	39582											
CBLB	868	broad.mit.edu	37	chr3	105572471	105572471	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagtatatatggtgggctaTttttcaactgaagtttggga	11	15	11	4	0	1	1	1	1	0	0	1	2	1	2	0	3	1	3	0	3	7	7			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr3:105572471T>C	uc003dwc.2	-	3	528	c.206A>G	c.(205-207)AAT>AGT	p.N69S	CBLB_uc011bhi.1_Missense_Mutation_p.N91S|CBLB_uc003dwd.1_Missense_Mutation_p.N69S|CBLB_uc003dwe.1_Missense_Mutation_p.N69S|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	69	Cbl-PTB.|4H.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TGGTGGGCTATTTTTCAACTG	0.289			Mis S		AML								58	6					0	0	0	0	C	105572471	C	C	105572471	3	2	215	1	0	0	0	0	1	0	0	0	2713	1493	52	5	2810	5	CBLB	3	105572471	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08	68699166	105572471	92449959	28	39583											
IGSF11	152404	broad.mit.edu	37	chr3	118623581	118623581	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctaaaattagtgcaatgcaAaaaatgataataactgcacc	19	9	5	8	0	0	1	0	1	0	0	0	1	0	1	2	0	4	3	2	0	9	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr3:118623581A>T	uc003ebw.2	-	6	1015	c.768T>A	c.(766-768)TTT>TTA	p.F256L	IGSF11_uc011biv.1_Intron|IGSF11_uc003ebx.2_Missense_Mutation_p.F232L|IGSF11_uc003eby.2_Missense_Mutation_p.F255L|IGSF11_uc003ebz.2_Missense_Mutation_p.F231L|IGSF11_uc010hqs.2_Missense_Mutation_p.F255L	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	256	Helical; (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						GTGCAATGCAAAAAATGATAA	0.348													81	137					0	0	0	0	T	118623581	T	T	118623581	3	4	215	1	0	0	0	0	1	0	0	0	7637	11	1	5	535	5	IGSF11	3	118623581	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	13051110	118623581	79398849	29	39584											
PLD1	5337	broad.mit.edu	37	chr3	171431702	171431702	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccttgaaagattatcaattcGgattccatatttcgtttctg	10	17	6	8	2	2	2	1	1	1	1	5	3	3	3	2	1	0	1	2	1	4	7			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr3:171431702G>A	uc003fhs.2	-	9	1008	c.892C>T	c.(892-894)CGA>TGA	p.R298*	PLD1_uc003fht.2_Nonsense_Mutation_p.R298*	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	298	PH.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TTATCAATTCGGATTCCATAT	0.338													86	9					0	0	0	0	A	171431702	A	A	171431702	4	1	215	1	0	0	0	0	0	1	0	0	12100	1124	39	1	2408	1	PLD1	3	171431702	Nonsense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	52808121	171431702	26590728	30	39585											
DGKG	1608	broad.mit.edu	37	chr3	185986617	185986617	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcaccacacgcagtgccgCgcggtgacactctggtagca	8	5	13	15	5	1	1	0	1	1	0	1	1	1	1	2	3	2	4	2	3	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr3:185986617C>T	uc003fqa.2	-	12	1626	c.1089G>A	c.(1087-1089)GCG>GCA	p.A363A	DGKG_uc003fqb.2_Intron|DGKG_uc003fqc.2_Silent_p.A363A|DGKG_uc011brx.1_Intron	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	363	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CGCAGTGCCGCGCGGTGACAC	0.612													21	30					0	0	0	0	T	185986617	T	T	185986617	2	4	215	1	0	0	0	0	0	0	0	1	4491	755	27	1		1	DGKG	3	185986617	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08	14554915	185986617	12035813	31	39586											
TECRL	253017	broad.mit.edu	37	chr4	65274963	65274963	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagagtacaagttttgacAaaaagtgaaaatttctcata	17	12	7	5	0	1	3	1	3	1	1	2	4	1	3	0	0	1	2	0	0	7	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr4:65274963A>G	uc003hcv.2	-	1	216	c.107T>C	c.(106-108)TTG>TCG	p.L36S	TECRL_uc003hcw.2_Missense_Mutation_p.L36S	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	36					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						AAGTTTTGACAAAAAGTGAAA	0.413													12	40					0	0	0	0	G	65274963	G	G	65274963	3	3	215	1	0	0	0	0	1	0	0	0	15812	131	5	5	1032	5	TECRL	4	65274963	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08		65274963	125879313	32	39587											
C4orf35	85438	broad.mit.edu	37	chr4	71201892	71201892	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagacacctccacaactgAaacggatatctttgaactac	15	8	7	11	1	1	3	0	2	1	1	2	5	2	5	2	2	4	0	2	2	6	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr4:71201892A>T	uc003hff.2	+	1	1222	c.1136A>T	c.(1135-1137)GAA>GTA	p.E379V		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	379						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				TCCACAACTGAAACGGATATC	0.398													29	12					0	0	0	0	T	71201892	T	T	71201892	3	4	215	1	0	0	0	0	1	0	0	0	2275	246	9	5	1138	5	C4orf35	4	71201892	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	5926929	71201892	119952384	33	39588											
ANKRD17	26057	broad.mit.edu	37	chr4	73984419	73984419	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttatacctttctaaatgctgCcataagaggagttatcttgc	11	15	7	8	0	2	1	0	0	2	1	2	2	2	2	2	1	4	2	2	1	6	7			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr4:73984419C>G	uc003hgp.2	-	22	4291	c.4174G>C	c.(4174-4176)GCA>CCA	p.A1392P	ANKRD17_uc003hgo.2_Missense_Mutation_p.A1279P|ANKRD17_uc003hgq.2_Missense_Mutation_p.A1141P|ANKRD17_uc003hgr.2_Missense_Mutation_p.A1391P|ANKRD17_uc011cbd.1_Missense_Mutation_p.A957P	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1392	ANK 25.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTAAATGCTGCCATAAGAGGA	0.423													47	19					0	0	0	0	G	73984419	G	G	73984419	3	3	215	1	0	0	0	0	1	0	0	0	646	739	26	4	3689	4	ANKRD17	4	73984419	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	2782527	73984419	117169857	34	39589											
SCAMP1	9522	broad.mit.edu	37	chr5	77714718	77714718	+	Frame_Shift_Del	DEL	T	-	-																															cagtaaagcttatgtactacTtgtggatgtgtgagtataca																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr5:77714718delT	uc003kfl.2	+	5	620	c.463delT	c.(463-465)TTGfs	p.L155fs	SCAMP1_uc010jaa.2_RNA|SCAMP1_uc011ctc.1_RNA|SCAMP1_uc011ctd.1_Intron|SCAMP1_uc003kfm.2_5'Flank	NM_004866	NP_004857	O15126	SCAM1_HUMAN	secretory carrier membrane protein 1	155	Cytoplasmic (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane|recycling endosome membrane|trans-Golgi network	protein binding				0		all_lung(232;0.000397)|Lung NSC(167;0.00105)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;1.9e-46)|Epithelial(54;9.4e-43)|all cancers(79;1.12e-37)		TATGTACTACTTGTGGATGTG	0.338													---	---	---								-	77714718	-	-	77714718	7	5	215	1	0	1	0	1	0	0	0	0	13935	1606	56	0	481	0	SCAMP1	5	77714718	Frame_Shift_Del	DEL	T	TCGA-CV-6962-01A-11D-1912-08		77714718	103200542	35	39590											
APC	324	broad.mit.edu	37	chr5	112175951	112175952	+	Frame_Shift_Ins	INS	-	A	A																															aaaccaagagaaagaggcagINSaaaaaactattgattctgaa																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr5:112175951_112175952insA	uc010jby.2	+	16	5040_5041	c.4660_4661insA	c.(4660-4662)GAAfs	p.E1554fs	APC_uc011cvt.1_Frame_Shift_Ins_p.E1536fs|APC_uc003kpz.3_Frame_Shift_Ins_p.E1554fs|APC_uc003kpy.3_Frame_Shift_Ins_p.E1554fs|APC_uc010jbz.2_Frame_Shift_Ins_p.E1271fs|APC_uc010jca.2_Frame_Shift_Ins_p.E854fs	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1554	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.T1556fs*3(35)|p.E1554fs*5(2)|p.E1554*(2)|p.?(1)|p.T1556fs*9(1)|p.K1192fs*3(1)|p.?fs(1)|p.E1554fs*11(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GAAAGAGGCAGAAAAAACTATT	0.342		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			---	---	---								A	112175952	A	A	112175951	7	5	215	1	0	1	1	0	0	0	0	0	763	943	33	0	4718	0	APC	5	112175951	Frame_Shift_Ins	INS	-	TCGA-CV-6962-01A-11D-1912-08	34461233	112175951	68739309	36	39591											
ADAMTS19	171019	broad.mit.edu	37	chr5	128796153	128796153	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcctttaccagctggggttCctgtcgaatgggatcgtttc	5	14	11	11	2	0	0	0	0	0	0	5	2	2	1	3	3	2	3	3	3	2	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr5:128796153C>T	uc003kvb.1	+	1	51	c.51C>T	c.(49-51)TTC>TTT	p.F17F	ADAMTS19_uc003kvc.1_5'Flank	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	17					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AGCTGGGGTTCCTGTCGAATG	0.622													56	19					0	0	0	0	T	128796153	T	T	128796153	2	4	215	1	0	0	0	0	0	0	0	1	264	854	30	2		2	ADAMTS19	5	128796153	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08	16620202	128796153	52119107	37	39592											
PCDHGA4	56111	broad.mit.edu	37	chr5	140734960	140734960	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctggcggagcgcggagtcCgcatcgtctccagaggtagg	7	6	17	11	5	1	1	0	0	1	1	4	3	2	3	2	5	2	3	2	5	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr5:140734960C>T	uc003ljq.1	+	1	193	c.193C>T	c.(193-195)CGC>TGC	p.R65C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.R65C	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	65	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGAGTCCGCATCGTCTC	0.647													51	23					0	0	0	0	T	140734960	T	T	140734960	3	4	215	1	0	0	0	0	1	0	0	0	11610	652	23	1	195	1	PCDHGA4	5	140734960	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	11938807	140734960	40180300	38	39593											
DOCK2	1794	broad.mit.edu	37	chr5	169472903	169472904	+	Frame_Shift_Ins	INS	-	A	A																															actatgagctgctcagccagINSaacctggtaaggcatcccct																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr5:169472903_169472904insA	uc003maf.2	+	39	4040_4041	c.3960_3961insA	c.(3958-3963)CAGAACfs	p.Q1320fs	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Frame_Shift_Ins_p.Q812fs	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1320_1321	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGCTCAGCCAGAACCTGGTAAG	0.584													---	---	---								A	169472904	A	A	169472903	7	5	215	1	0	1	1	0	0	0	0	0	4709	933	33	0	4114	0	DOCK2	5	169472903	Frame_Shift_Ins	INS	-	TCGA-CV-6962-01A-11D-1912-08	28737943	169472903	11442357	39	39594											
KIF13A	63971	broad.mit.edu	37	chr6	17764996	17764996	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tactgctggtggtagggctaCgggacacttctttctccaag	7	12	12	10	1	2	0	0	0	2	0	3	1	2	1	1	4	3	3	1	4	4	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr6:17764996C>A	uc003ncg.3	-	39	4868	c.4763G>T	c.(4762-4764)CGT>CTT	p.R1588L	KIF13A_uc003ncf.2_Missense_Mutation_p.R1540L|KIF13A_uc003nch.3_Missense_Mutation_p.R1553L|KIF13A_uc003nci.3_Missense_Mutation_p.R1540L|KIF13A_uc003nce.1_Missense_Mutation_p.R139L	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1588					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GGTAGGGCTACGGGACACTTC	0.502													11	6					3.86212e-05	4.14105e-05	1	0	A	17764996	A	A	17764996	3	1	215	1	0	0	0	0	1	0	0	0	8313	536	19	3	683	3	KIF13A	6	17764996	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08		17764996	153350071	40	39595											
HIST1H2AE	3012	broad.mit.edu	37	chr6	26217266	26217266	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctaaaacgcgttcttccaggGccggtcttcagtttccagtt	7	13	9	12	3	3	0	1	0	2	0	5	0	5	0	3	2	1	3	3	2	2	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr6:26217266G>A	uc003nha.1	+	1	119	c.64G>A	c.(64-66)GCC>ACC	p.A22T	HIST1H2BG_uc003ngz.2_5'Flank	NM_021052	NP_066390	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	22					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2		all_hematologic(11;0.196)				TTCTTCCAGGGCCGGTCTTCA	0.577													22	12					0	0	0	0	A	26217266	A	A	26217266	3	1	215	1	0	0	0	0	1	0	0	0	7171	1203	42	4	66	4	HIST1H2AE	6	26217266	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	8452270	26217266	144897801	41	39596											
TNRC18	84629	broad.mit.edu	37	chr7	5391493	5391493	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcgctgaaggaggaacgCgcctcggcctctcgaagcag	9	5	15	12	5	1	1	0	1	1	0	4	5	1	3	2	3	2	2	2	3	3	0			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:5391493C>T	uc003soi.3	-	17	5776	c.5427G>A	c.(5425-5427)GCG>GCA	p.A1809A	TNRC18_uc003soj.2_Silent_p.A191A	NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1809							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AGGAGGAACGCGCCTCGGCCT	0.592													15	12					0	0	0	0	T	5391493	T	T	5391493	2	4	215	1	0	0	0	0	0	0	0	1	16405	755	27	1		1	TNRC18	7	5391493	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08		5391493	153747170	42	39597											
HDAC9	9734	broad.mit.edu	37	chr7	18625006	18625006	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggtggaccctgttgtccGtgagaagcaattgcagcagg	8	9	15	9	2	0	1	0	1	0	1	1	3	1	2	2	3	3	4	2	3	2	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:18625006G>A	uc003suh.2	+	2	166	c.125G>A	c.(124-126)CGT>CAT	p.R42H	HDAC9_uc003sue.2_Missense_Mutation_p.R42H|HDAC9_uc011jyd.1_Missense_Mutation_p.R42H|HDAC9_uc003sui.2_Missense_Mutation_p.R42H|HDAC9_uc003suj.2_Missense_Mutation_p.R42H|HDAC9_uc011jya.1_Missense_Mutation_p.R83H|HDAC9_uc003sua.1_Missense_Mutation_p.R61H|HDAC9_uc011jyb.1_Missense_Mutation_p.R42H|HDAC9_uc003sud.1_Missense_Mutation_p.R42H|HDAC9_uc011jyc.1_Missense_Mutation_p.R42H|HDAC9_uc003suf.1_Missense_Mutation_p.R70H|HDAC9_uc010kud.1_Missense_Mutation_p.R42H|HDAC9_uc011jye.1_Missense_Mutation_p.R11H|HDAC9_uc011jyf.1_Missense_Mutation_p.R11H	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	42					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CCTGTTGTCCGTGAGAAGCAA	0.493													48	87					0	0	0	0	A	18625006	A	A	18625006	3	1	215	1	0	0	0	0	1	0	0	0	7053	1145	40	1	131	1	HDAC9	7	18625006	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	13233513	18625006	140513657	43	39598											
OSBPL3	26031	broad.mit.edu	37	chr7	24874174	24874174	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtactccagctcctcgcaGagcctctgcagcgtgttcag	6	10	10	15	2	2	1	1	0	1	1	5	1	4	1	3	0	5	5	3	0	1	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:24874174G>A	uc003sxf.2	-	15	2082	c.1677C>T	c.(1675-1677)CTC>CTT	p.L559L	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Silent_p.L523L|OSBPL3_uc003sxh.2_Silent_p.L528L|OSBPL3_uc003sxi.2_Silent_p.L492L|OSBPL3_uc003sxj.1_Silent_p.L288L|OSBPL3_uc003sxk.1_Silent_p.L257L	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	559					lipid transport		lipid binding|protein binding			skin(1)	1						GCTCCTCGCAGAGCCTCTGCA	0.617													44	68					0	0	0	0	A	24874174	A	A	24874174	2	1	215	1	0	0	0	0	0	0	0	1	11333	929	33	2		2	OSBPL3	7	24874174	Silent	SNP	G	TCGA-CV-6962-01A-11D-1912-08	6249168	24874174	134264489	44	39599											
CDK13	8621	broad.mit.edu	37	chr7	40037230	40037230	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagtccagaggaaaagaaaaCagcaacacagttacatagta	20	5	9	7	0	0	2	0	0	0	2	1	4	1	3	1	1	4	3	1	1	8	3	rs34775357	byFrequency	TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:40037230C>G	uc003thh.3	+	3	2291	c.2009C>G	c.(2008-2010)ACA>AGA	p.T670R	CDK13_uc003thi.3_Missense_Mutation_p.T670R|CDK13_uc011kbf.1_Missense_Mutation_p.T56R	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	670					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity	p.T670R(1)		lung(2)|skin(2)|ovary(1)	5						GAAAAGAAAACAGCAACACAG	0.433													3	123					0	0	0	0	G	40037230	G	G	40037230	3	3	215	1	0	0	0	0	1	0	0	0	3144	478	17	4	2019	4	CDK13	7	40037230	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	15163056	40037230	119101433	45	39600											
HECW1	23072	broad.mit.edu	37	chr7	43503399	43503399	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atcttcccagtccagcttagGtattggaggaggggtcccca	8	10	12	11	0	1	0	0	0	1	0	4	2	4	2	4	5	1	2	4	5	2	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:43503399G>A	uc003tid.1	+	14	3396	c.2791_splice	c.e14+1	p.D931_splice	HECW1_uc011kbi.1_Splice_Site_p.D897_splice	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TCCAGCTTAGGTATTGGAGGA	0.602													61	82					0	0	0	0	A	43503399	A	A	43503399	5	1	215	1	0	0	0	0	0	0	1	0	7081	1275	44	4	2838	4	HECW1	7	43503399	Splice_Site	SNP	G	TCGA-CV-6962-01A-11D-1912-08	3466169	43503399	115635264	46	39601											
ADCY1	107	broad.mit.edu	37	chr7	45614734	45614734	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggctgcgtcgcacttgctgGtcacagccaccttggtcccc	4	10	11	16	2	1	0	1	0	0	0	3	0	2	0	4	3	3	3	4	3	0	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:45614734G>T	uc003tne.3	+	1	610	c.592G>T	c.(592-594)GTC>TTC	p.V198F	ADCY1_uc003tnd.2_5'UTR	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	198	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCACTTGCTGGTCACAGCCAC	0.642													17	27					2.5808e-16	3.00057e-16	1	0	T	45614734	T	T	45614734	3	4	215	1	0	0	0	0	1	0	0	0	292	1261	44	4	594	4	ADCY1	7	45614734	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	2111335	45614734	113523929	47	39602											
COL1A2	1278	broad.mit.edu	37	chr7	94038122	94038122	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccctccaggcttcccaggtgCccctggccccaaggtaaaaa	9	6	9	17	0	0	0	0	0	0	0	2	0	2	0	7	4	1	2	7	4	4	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:94038122C>A	uc003ung.1	+	16	1250	c.779C>A	c.(778-780)GCC>GAC	p.A260D	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	260					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTCCCAGGTGCCCCTGGCCCC	0.433										HNSCC(75;0.22)			7	63					1.26484e-09	1.41927e-09	1	0	A	94038122	A	A	94038122	3	1	215	1	0	0	0	0	1	0	0	0	3693	739	26	4	841	4	COL1A2	7	94038122	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	48423388	94038122	65100541	48	39603											
PON3	5446	broad.mit.edu	37	chr7	94996800	94996800	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cataaagatacacagtattgTctacatggaaaaaagggata	19	9	8	5	0	1	1	0	0	1	1	1	3	1	3	0	2	2	1	0	2	9	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:94996800T>C	uc003unt.2	-	5	393	c.368A>G	c.(367-369)GAC>GGC	p.D123G	PON1_uc011kih.1_Intron|PON3_uc011kii.1_Missense_Mutation_p.D171G	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	123					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			CACAGTATTGTCTACATGGAA	0.313													85	63					0	0	0	0	C	94996800	C	C	94996800	3	2	215	1	0	0	0	0	1	0	0	0	12305	1681	58	5	716	5	PON3	7	94996800	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08	958678	94996800	64141863	49	39604											
ASNS	440	broad.mit.edu	37	chr7	97488686	97488686	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacttttaaaaagggagtcGcggagtgcttcaatgtaaca	13	10	10	8	2	1	0	1	0	0	0	2	2	1	2	1	2	2	2	1	2	5	4	rs138299423		TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:97488686G>A	uc003uot.3	-	5	1018	c.512C>T	c.(511-513)GCG>GTG	p.A171V	ASNS_uc011kin.1_Missense_Mutation_p.A88V|ASNS_uc003uou.3_Missense_Mutation_p.A171V|ASNS_uc003uov.3_Missense_Mutation_p.A171V|ASNS_uc011kio.1_Missense_Mutation_p.A150V|ASNS_uc003uow.3_Missense_Mutation_p.A150V|ASNS_uc003uox.3_Missense_Mutation_p.A88V	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	171	Glutamine amidotransferase type-2.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AAAGGGAGTCGCGGAGTGCTT	0.368													39	63					0	0	0	0	A	97488686	A	A	97488686	3	1	215	1	0	0	0	0	1	0	0	0	1050	1087	38	1	1209	1	ASNS	7	97488686	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	2491886	97488686	61649977	50	39605											
MUC17	140453	broad.mit.edu	37	chr7	100676474	100676474	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggctagcaccacttcaacaActcctgctgactccaacact	12	8	5	16	0	1	1	1	1	0	0	3	1	3	1	3	1	5	3	3	1	4	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:100676474A>G	uc003uxp.1	+	3	1830	c.1777A>G	c.(1777-1779)ACT>GCT	p.T593A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	593	Extracellular (Potential).|7.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACTTCAACAACTCCTGCTGA	0.478													8	665					0	0	0	0	G	100676474	G	G	100676474	3	3	215	1	0	0	0	0	1	0	0	0	10027	43	2	5	1787	5	MUC17	7	100676474	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	3187788	100676474	58462189	51	39606											
MUC17	140453	broad.mit.edu	37	chr7	100684754	100684754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctttcagcaccacgccagtgGtcagttctgaggctagcacc	8	9	10	14	1	3	1	2	1	1	0	3	1	3	1	3	2	2	4	3	2	1	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:100684754G>A	uc003uxp.1	+	3	10110	c.10057G>A	c.(10057-10059)GTC>ATC	p.V3353I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3353	Extracellular (Potential).|54.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACGCCAGTGGTCAGTTCTGA	0.483													450	370					0	0	0	0	A	100684754	A	A	100684754	3	1	215	1	0	0	0	0	1	0	0	0	10027	1261	44	4	10067	4	MUC17	7	100684754	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	8280	100684754	58453909	52	39607											
SERPINE1	5054	broad.mit.edu	37	chr7	100771855	100771855	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgtggttttctcaccctatGgggtggcctcggtgttggcc	3	13	14	11	2	1	0	1	0	1	0	3	0	1	0	3	6	0	2	3	6	1	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:100771855G>A	uc003uxt.2	+	2	329	c.181G>A	c.(181-183)GGG>AGG	p.G61R	SERPINE1_uc011kkj.1_Missense_Mutation_p.G46R|SERPINE1_uc003uxu.1_5'Flank	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	61					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	CTCACCCTATGGGGTGGCCTC	0.592													37	37					0	0	0	0	A	100771855	A	A	100771855	3	1	215	1	0	0	0	0	1	0	0	0	14176	1348	47	4	183	4	SERPINE1	7	100771855	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	87101	100771855	58366808	53	39608											
SRPK2	6733	broad.mit.edu	37	chr7	104787081	104787081	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatgatcttgcacttactgtGtaagtaatctaacccttgaa	13	14	6	8	0	2	2	0	2	2	0	2	2	2	2	1	0	3	3	1	0	6	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:104787081G>T	uc003vct.2	-	7	800	c.613C>A	c.(613-615)CAC>AAC	p.H205N	SRPK2_uc003vcu.2_Missense_Mutation_p.H205N|SRPK2_uc003vcv.2_Missense_Mutation_p.H216N|SRPK2_uc003vcw.1_Missense_Mutation_p.H205N	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	205	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CACTTACTGTGTAAGTAATCT	0.338													10	37					3.03607e-14	3.50875e-14	1	0	T	104787081	T	T	104787081	3	4	215	1	0	0	0	0	1	0	0	0	15226	1377	48	4	1489	4	SRPK2	7	104787081	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	4015226	104787081	54351582	54	39609											
BCAP29	55973	broad.mit.edu	37	chr7	107234422	107234422	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctgtgagagaagtaaggaaAtattcctcagttcataccat	14	11	9	7	0	2	2	2	1	0	1	3	4	3	3	2	1	1	3	2	1	5	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:107234422A>G	uc003vej.2	+	4	555	c.216A>G	c.(214-216)AAA>AAG	p.K72K	BCAP29_uc011kly.1_5'UTR|BCAP29_uc011klz.1_Silent_p.K72K|BCAP29_uc011kma.1_Silent_p.K72K	NM_018844	NP_061332	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein BAP29 isoform	72	Lumenal (Potential).				apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				large_intestine(1)|ovary(1)	2						AAGTAAGGAAATATTCCTCAG	0.353													49	33					0	0	0	0	G	107234422	G	G	107234422	2	3	215	1	0	0	0	0	0	0	0	1	1348	98	4	5		5	BCAP29	7	107234422	Silent	SNP	A	TCGA-CV-6962-01A-11D-1912-08	2447341	107234422	51904241	55	39610											
NRCAM	4897	broad.mit.edu	37	chr7	107831704	107831704	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcatattagtttaccgtaaaCgggagctggagttggagtag	11	12	13	5	2	1	0	1	0	0	0	1	3	1	3	1	3	3	5	1	3	6	7			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:107831704C>T	uc003vfb.2	-	19	2398	c.1927G>A	c.(1927-1929)GTT>ATT	p.V643I	NRCAM_uc003vfc.2_Intron|NRCAM_uc011kmk.1_Missense_Mutation_p.V638I|NRCAM_uc003vfd.2_Missense_Mutation_p.V619I|NRCAM_uc003vfe.2_Missense_Mutation_p.V619I	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	643	Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TTACCGTAAACGGGAGCTGGA	0.318													9	15					0	0	0	0	T	107831704	T	T	107831704	3	4	215	1	0	0	0	0	1	0	0	0	10698	536	19	1	2077	1	NRCAM	7	107831704	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	597282	107831704	51306959	56	39611											
PNPLA8	50640	broad.mit.edu	37	chr7	108154727	108154727	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgttatcaatactcaccCttgcgataatctacaaagac	13	12	4	12	1	3	1	2	0	1	1	4	2	4	1	2	0	3	1	2	0	6	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:108154727C>T	uc003vff.1	-	5	1474	c.1067G>A	c.(1066-1068)AGG>AAG	p.R356K	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Missense_Mutation_p.R356K|PNPLA8_uc003vfi.1_Missense_Mutation_p.R256K|PNPLA8_uc003vfj.1_Missense_Mutation_p.R356K|PNPLA8_uc003vfk.1_Missense_Mutation_p.R256K	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	356					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						AATACTCACCCTTGCGATAAT	0.348													157	156					0	0	0	0	T	108154727	T	T	108154727	3	4	215	1	0	0	0	0	1	0	0	0	12226	681	24	4	1313	4	PNPLA8	7	108154727	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	323023	108154727	50983936	57	39612											
HYAL4	23553	broad.mit.edu	37	chr7	123508362	123508362	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaggacagttaaagctttGtgttgttcaaccagtacatc	12	13	9	7	0	1	1	1	1	0	0	2	2	1	2	1	1	3	5	1	1	5	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:123508362G>A	uc003vlc.2	+	3	673	c.35G>A	c.(34-36)TGT>TAT	p.C12Y	HYAL4_uc011knz.1_Missense_Mutation_p.C12Y	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	12	Helical; (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						TTAAAGCTTTGTGTTGTTCAA	0.348													42	75					0	0	0	0	A	123508362	A	A	123508362	3	1	215	1	0	0	0	0	1	0	0	0	7505	1377	48	4	37	4	HYAL4	7	123508362	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	15353635	123508362	35630301	58	39613											
FLNC	2318	broad.mit.edu	37	chr7	128488731	128488731	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggagttcaccatcgacgCacgggacgcgggcgaggggt	7	6	18	10	6	1	0	1	0	0	0	2	4	1	2	1	5	0	2	1	5	0	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:128488731C>G	uc003vnz.3	+	27	4906	c.4697C>G	c.(4696-4698)GCA>GGA	p.A1566G	FLNC_uc003voa.3_Missense_Mutation_p.A1566G	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1566	Filamin 14.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						ACCATCGACGCACGGGACGCG	0.662													41	133					0	0	0	0	G	128488731	G	G	128488731	3	3	215	1	0	0	0	0	1	0	0	0	5967	710	25	4	4803	4	FLNC	7	128488731	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	4980369	128488731	30649932	59	39614											
KLF14	136259	broad.mit.edu	37	chr7	130418557	130418557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggagcttcccccgagttctCccaggagccctcgccagagc	6	7	11	17	2	1	1	0	0	1	1	4	4	2	3	5	2	3	2	5	2	0	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:130418557C>T	uc003vqk.1	-	1	304	c.304G>A	c.(304-306)GAG>AAG	p.E102K		NM_138693	NP_619638	Q8TD94	KLF14_HUMAN	Kruppel-like factor 14	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(18;0.0435)					CCCGAGTTCTCCCAGGAGCCC	0.587													4	5					0	0	0	0	T	130418557	T	T	130418557	3	4	215	1	0	0	0	0	1	0	0	0	8381	864	30	2	671	2	KLF14	7	130418557	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	1929826	130418557	28720106	60	39615											
EPHB6	2051	broad.mit.edu	37	chr7	142568363	142568363	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcctggctttcagccattgGactggagtgctaccaggaca	8	9	13	11	0	1	0	1	0	0	0	1	3	1	3	3	5	3	2	3	5	1	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:142568363G>T	uc011kst.1	+	19	3669	c.2882G>T	c.(2881-2883)GGA>GTA	p.G961V	EPHB6_uc011ksu.1_Missense_Mutation_p.G961V|EPHB6_uc003wbs.2_Missense_Mutation_p.G669V|EPHB6_uc003wbt.2_Missense_Mutation_p.G435V|EPHB6_uc003wbu.2_Missense_Mutation_p.G669V|EPHB6_uc003wbv.2_Missense_Mutation_p.G345V	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	961	SAM.|Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					TCAGCCATTGGACTGGAGTGC	0.597													36	127					9.17885e-22	1.11416e-21	1	0	T	142568363	T	T	142568363	3	4	215	1	0	0	0	0	1	0	0	0	5202	1174	41	2	2940	2	EPHB6	7	142568363	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	12149806	142568363	16570300	61	39616											
GIMAP6	474344	broad.mit.edu	37	chr7	150325295	150325295	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccgtgaaccggcccagttGtgtcaccaggagcacggcgt	8	7	13	13	4	1	1	1	1	0	0	2	2	2	2	4	3	2	2	4	3	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr7:150325295G>A	uc003whn.2	-	3	815	c.391C>T	c.(391-393)CAA>TAA	p.Q131*	GIMAP6_uc003whm.2_Nonsense_Mutation_p.Q51*	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	131							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGGCCCAGTTGTGTCACCAGG	0.632													17	89					0	0	0	0	A	150325295	A	A	150325295	4	1	215	1	0	0	0	0	0	1	0	0	6420	1386	48	4	491	4	GIMAP6	7	150325295	Nonsense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	7756932	150325295	8813368	62	39617											
RHOBTB2	23221	broad.mit.edu	37	chr8	22864434	22864434	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccacctccgcaatgtgcagCggcctctgctgcaggcaccc	6	6	10	19	2	1	0	0	0	1	0	2	0	2	0	5	2	4	5	5	2	1	0			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr8:22864434C>T	uc003xcq.2	+	5	1213	c.676C>T	c.(676-678)CGG>TGG	p.R226W	RHOBTB2_uc003xcp.2_Missense_Mutation_p.R248W|RHOBTB2_uc011kzp.1_Missense_Mutation_p.R233W|uc003xcr.2_RNA	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	226					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		CAATGTGCAGCGGCCTCTGCT	0.662													52	19					0	0	0	0	T	22864434	T	T	22864434	3	4	215	1	0	0	0	0	1	0	0	0	13399	759	27	1	775	1	RHOBTB2	8	22864434	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08		22864434	123499588	63	39618											
ENTPD4	9583	broad.mit.edu	37	chr8	23243522	23243522	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcacaacacagctttggacaAccccctgagcaaggtattat	13	8	8	12	0	0	1	0	1	0	0	0	2	0	2	2	2	4	4	2	2	5	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr8:23243522A>T	uc011kzu.1	-	13	1907	c.1635T>A	c.(1633-1635)GGT>GGA	p.G545G	LOXL2_uc003xdh.1_Intron	NM_001128930	NP_001122402	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	Error:Variant_position_missing_in_Q9Y227_after_alignment					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		gCTTTGGacaaccccctgagc	0.015													39	14					0	0	0	0	T	23243522	T	T	23243522	2	4	215	1	0	0	0	0	0	0	0	1	5165	58	2	5		5	ENTPD4	8	23243522	Silent	SNP	A	TCGA-CV-6962-01A-11D-1912-08	379088	23243522	123120500	64	39619											
CLVS1	157807	broad.mit.edu	37	chr8	62289235	62289235	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcgaagatccggagcttcAgataaatggcttcattttaa	14	12	8	7	2	2	2	2	0	0	2	4	4	3	3	1	2	1	2	1	2	5	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr8:62289235A>G	uc003xuh.2	+	3	851	c.527A>G	c.(526-528)CAG>CGG	p.Q176R	CLVS1_uc003xug.2_3'UTR|CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Missense_Mutation_p.Q176R	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	176	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						CCGGAGCTTCAGATAAATGGC	0.448													3	82					0	0	0	0	G	62289235	G	G	62289235	3	3	215	1	0	0	0	0	1	0	0	0	3586	188	7	5	533	5	CLVS1	8	62289235	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	39045713	62289235	84074787	65	39620											
TRHR	7201	broad.mit.edu	37	chr8	110099852	110099852	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgtactcattatttgtggCctgggcattgtaggcaacat	8	15	10	8	0	1	0	1	0	0	0	1	0	1	0	1	3	2	4	1	3	4	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr8:110099852C>A	uc003ymz.3	+	1	127	c.111C>A	c.(109-111)GGC>GGA	p.G37G		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	37	Helical; Name=1; (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			TTATTTGTGGCCTGGGCATTG	0.507													38	53					3.21399e-22	3.95096e-22	1	0	A	110099852	A	A	110099852	2	1	215	1	0	0	0	0	0	0	0	1	16547	726	26	4		4	TRHR	8	110099852	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08	47810617	110099852	36264170	66	39621											
KCNV1	27012	broad.mit.edu	37	chr8	110980617	110980617	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgattttgcctgtggtggtGtctggtctaatgtccccata	6	15	11	9	1	2	0	0	0	2	0	3	1	3	0	3	3	1	0	3	3	2	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr8:110980617G>T	uc003ynr.3	-	3	1545	c.1203C>A	c.(1201-1203)GAC>GAA	p.D401E	KCNV1_uc010mcw.2_Missense_Mutation_p.D401E	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	401						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CTGTGGTGGTGTCTGGTCTAA	0.478													43	73					4.67007e-22	5.70457e-22	1	0	T	110980617	T	T	110980617	3	4	215	1	0	0	0	0	1	0	0	0	8133	1368	48	4	303	4	KCNV1	8	110980617	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	880765	110980617	35383405	67	39622											
CDKN2A	1029	broad.mit.edu	37	chr9	21971029	21971029	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccacgggcagacggcccCaggcatcgcgcacgtccagc	7	3	14	17	5	0	1	0	0	0	1	3	1	2	1	4	4	1	3	4	4	0	0			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr9:21971029C>T	uc003zpk.2	-	2	541	c.329G>A	c.(328-330)TGG>TAG	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.L165L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGACGGCCCCAGGCATCGCG	0.731		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			43	5					0	0	0	0	T	21971029	T	T	21971029	4	4	215	1	0	0	0	0	0	1	0	0	3176	595	21	4	149	4	CDKN2A	9	21971029	Nonsense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08		21971029	119242402	68	39623											
KIAA1958	158405	broad.mit.edu	37	chr9	115407987	115407987	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattaatgatgacttgaatgAtctgtgtaccagtgcagtaa	13	14	9	5	0	1	4	0	4	1	0	1	4	1	4	1	0	2	3	1	0	5	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr9:115407987A>G	uc004bgf.1	+	3	1404	c.1229A>G	c.(1228-1230)GAT>GGT	p.D410G	KIAA1958_uc011lwx.1_Missense_Mutation_p.D438G	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	410										skin(1)	1						GACTTGAATGATCTGTGTACC	0.383													16	40					0	0	0	0	G	115407987	G	G	115407987	3	3	215	1	0	0	0	0	1	0	0	0	8303	333	12	5	1235	5	KIAA1958	9	115407987	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	93436958	115407987	25805444	69	39624											
NOTCH1	4851	broad.mit.edu	37	chr9	139412359	139412359	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggagcccagcgtgttgatgCacttgcccgcatgctcgcag	7	8	13	13	3	0	1	0	1	0	0	1	2	0	2	2	1	5	5	2	1	0	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr9:139412359C>T	uc004chz.2	-	8	1286	c.1286G>A	c.(1285-1287)TGC>TAC	p.C429Y		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	429	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGTGTTGATGCACTTGCCCGC	0.662			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			38	37					0	0	0	0	T	139412359	T	T	139412359	3	4	215	1	0	0	0	0	1	0	0	0	10601	710	25	4	6489	4	NOTCH1	9	139412359	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	24004372	139412359	1801072	70	39625											
ARMC4	55130	broad.mit.edu	37	chr10	28270429	28270429	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttctgaaaattttggtgatTtttctcttaaaaatgtgaca	12	19	6	4	0	2	3	0	3	2	0	3	3	2	3	0	1	0	0	0	1	5	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr10:28270429T>C	uc009xky.2	-	7	1000	c.902A>G	c.(901-903)AAA>AGA	p.K301R	ARMC4_uc010qds.1_5'UTR|ARMC4_uc010qdt.1_5'UTR|ARMC4_uc001itz.2_Missense_Mutation_p.K301R|ARMC4_uc010qdu.1_5'UTR	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	301							binding			ovary(4)|skin(2)	6						TTTTGGTGATTTTTCTCTTAA	0.294													42	9					0	0	0	0	C	28270429	C	C	28270429	3	2	215	1	0	0	0	0	1	0	0	0	955	1841	64	5	2288	5	ARMC4	10	28270429	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08		28270429	107264318	71	39626											
ITGB1	3688	broad.mit.edu	37	chr10	33199209	33199209	+	Nonsense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccattcactgaatacgtaaaAtagaaccaacagtcgtcaac	17	8	5	11	2	2	2	2	1	0	1	3	2	2	2	2	0	4	1	2	0	8	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr10:33199209A>C	uc001iws.3	-	14	2242	c.2106T>G	c.(2104-2106)TAT>TAG	p.Y702*	ITGB1_uc001iwp.3_Nonsense_Mutation_p.Y702*|ITGB1_uc001iwq.3_Nonsense_Mutation_p.Y702*|ITGB1_uc001iwr.3_Nonsense_Mutation_p.Y702*|ITGB1_uc001iwt.3_Nonsense_Mutation_p.Y702*|ITGB1_uc001iwu.1_Nonsense_Mutation_p.Y702*	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	702	Extracellular (Potential).				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				AATACGTAAAATAGAACCAAC	0.433													17	8					0	0	0	0	C	33199209	C	C	33199209	4	2	215	1	0	0	0	0	0	1	0	0	7929	108	4	5	540	5	ITGB1	10	33199209	Nonsense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	4928780	33199209	102335538	72	39627											
RBP3	5949	broad.mit.edu	37	chr10	48388214	48388214	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgggcatggatgcatataaGgggctgctgcccacctggta	8	9	15	9	0	0	0	0	0	0	0	0	1	0	1	2	5	3	5	2	5	3	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr10:48388214G>T	uc001jez.2	-	1	2778	c.2664C>A	c.(2662-2664)CCC>CCA	p.P888P		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	888	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	ATGCATATAAGGGGCTGCTGC	0.647													18	13					6.94344e-10	7.83675e-10	1	0	T	48388214	T	T	48388214	2	4	215	1	0	0	0	0	0	0	0	1	13222	987	35	4		4	RBP3	10	48388214	Silent	SNP	G	TCGA-CV-6962-01A-11D-1912-08	15189005	48388214	87146533	73	39628											
NRAP	4892	broad.mit.edu	37	chr10	115384664	115384664	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtatactgatggacagacTgctcatttcctgccttgtag	8	14	10	9	0	1	2	1	1	0	1	2	3	2	3	2	2	3	3	2	2	3	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr10:115384664T>A	uc001laj.2	-	22	2434	c.2270A>T	c.(2269-2271)CAG>CTG	p.Q757L	NRAP_uc009xyb.2_Missense_Mutation_p.Q68L|NRAP_uc001lak.2_Missense_Mutation_p.Q722L|NRAP_uc001lal.3_Missense_Mutation_p.Q757L	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	757	Nebulin 18.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		ATGGACAGACTGCTCATTTCC	0.567													39	12					0	0	0	0	A	115384664	A	A	115384664	3	1	215	1	0	0	0	0	1	0	0	0	10692	1580	55	5	3006	5	NRAP	10	115384664	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08	66996450	115384664	20150083	74	39629											
EBF3	253738	broad.mit.edu	37	chr10	131640476	131640476	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtgtgtgcagggttgttgcCcagggtggggatctggttgt	3	13	19	6	1	1	0	0	0	1	0	1	1	1	1	1	5	2	4	1	5	0	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr10:131640476C>A	uc001lki.1	-	13	1308	c.1249G>T	c.(1249-1251)GGC>TGC	p.G417C		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	426					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GGGTTGTTGCCCAGGGTGGGG	0.597													64	41					1.42676e-28	1.81161e-28	1	0	A	131640476	A	A	131640476	3	1	215	1	0	0	0	0	1	0	0	0	4904	623	22	4	422	4	EBF3	10	131640476	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	16255812	131640476	3894271	75	39630											
NLRP6	171389	broad.mit.edu	37	chr11	284488	284488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccacagggtacagctgcctGacccccagcgagggctccag	8	4	12	17	1	0	1	0	1	0	0	1	2	1	1	5	2	4	3	5	2	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:284488G>A	uc010qvs.1	+	7	2386	c.2386G>A	c.(2386-2388)GAC>AAC	p.D796N	NLRP6_uc010qvt.1_Missense_Mutation_p.D795N	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	796						cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		ACAGCTGCCTGACCCCCAGCG	0.697													18	7					0	0	0	0	A	284488	A	A	284488	3	1	215	1	0	0	0	0	1	0	0	0	10535	1290	45	2	2412	2	NLRP6	11	284488	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08		284488	134722028	76	39631											
OR51A4	401666	broad.mit.edu	37	chr11	4967665	4967665	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	attcccagtacagtcttgagGatcagggtgtaagacacagc	12	9	11	9	0	2	2	1	1	1	1	3	3	3	3	1	2	2	2	1	2	2	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:4967665G>C	uc010qys.1	-	1	666	c.666C>G	c.(664-666)ATC>ATG	p.I222M		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGTCTTGAGGATCAGGGTGT	0.433													23	13					0	0	0	0	C	4967665	C	C	4967665	3	2	215	1	0	0	0	0	1	0	0	0	11141	1164	41	2	277	2	OR51A4	11	4967665	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	4683177	4967665	130038851	77	39632											
PIK3C2A	5286	broad.mit.edu	37	chr11	17139063	17139063	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctgatccactagcctgcCttactttttctgctactcct	5	16	6	14	0	1	1	0	1	1	0	3	1	3	1	4	1	5	2	4	1	3	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:17139063C>T	uc001mmq.3	-	18	3257	c.3191G>A	c.(3190-3192)AGG>AAG	p.R1064K	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.R684K|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1064					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	ACTAGCCTGCCTTACTTTTTC	0.393													51	13					0	0	0	0	T	17139063	T	T	17139063	3	4	215	1	0	0	0	0	1	0	0	0	11964	681	24	4	1929	4	PIK3C2A	11	17139063	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	12171398	17139063	117867453	78	39633											
SLC6A5	9152	broad.mit.edu	37	chr11	20652257	20652257	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggacactctaattgtcacctGcaccaacagtgccacaagca	13	7	7	14	0	2	0	1	0	1	0	2	1	2	1	3	1	4	2	3	1	3	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:20652257G>A	uc001mqd.2	+	10	1793	c.1520G>A	c.(1519-1521)TGC>TAC	p.C507Y	SLC6A5_uc009yic.2_Missense_Mutation_p.C272Y	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	507	Helical; Name=7; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	ATTGTCACCTGCACCAACAGT	0.493													5	115					0	0	0	0	A	20652257	A	A	20652257	3	1	215	1	0	0	0	0	1	0	0	0	14751	1319	46	4	1558	4	SLC6A5	11	20652257	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	3513194	20652257	114354259	79	39634											
OR4C6	219432	broad.mit.edu	37	chr11	55432771	55432771	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctggaaaatctacttatTgtggtaactattatcacaag	13	14	8	6	0	2	0	1	0	1	0	2	1	2	1	0	2	3	2	0	2	8	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:55432771T>C	uc001nht.3	+	3	394	c.129T>C	c.(127-129)ATT>ATC	p.I43I	OR4C6_uc010rik.1_Silent_p.I43I	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						ATCTACTTATTGTGGTAACTA	0.408													82	66					0	0	0	0	C	55432771	C	C	55432771	2	2	215	1	0	0	0	0	0	0	0	1	11106	1800	63	5		5	OR4C6	11	55432771	Silent	SNP	T	TCGA-CV-6962-01A-11D-1912-08	34780514	55432771	79573745	80	39635											
OR8I2	120586	broad.mit.edu	37	chr11	55861497	55861497	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggcagaaggccttctcCacctgcgcatcccacctcat	8	7	9	17	1	2	1	1	0	1	1	4	1	3	1	5	3	1	3	5	3	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:55861497C>A	uc010rix.1	+	1	714	c.714C>A	c.(712-714)TCC>TCA	p.S238S		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					AGGCCTTCTCCACCTGCGCAT	0.493													62	66					4.60343e-24	5.80694e-24	1	0	A	55861497	A	A	55861497	2	1	215	1	0	0	0	0	0	0	0	1	11294	581	21	4		4	OR8I2	11	55861497	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08	428726	55861497	79145019	81	39636											
OR8J3	81168	broad.mit.edu	37	chr11	55904545	55904545	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaaacaatattgaaataaGatactagaactgtaatcatg	21	10	5	5	0	1	3	1	1	0	2	1	3	1	3	0	0	3	1	0	0	10	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:55904545G>T	uc010riz.1	-	1	650	c.650C>A	c.(649-651)TCT>TAT	p.S217Y		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					ATTGAAATAAGATACTAGAAC	0.363													26	42					2.41591e-17	2.82588e-17	1	0	T	55904545	T	T	55904545	3	4	215	1	0	0	0	0	1	0	0	0	11296	942	33	2	299	2	OR8J3	11	55904545	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	43048	55904545	79101971	82	39637											
OR4D6	219983	broad.mit.edu	37	chr11	59224764	59224764	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccactttgctggtggggcaGatatttttttcctctctgtg	4	18	10	9	0	1	1	0	0	1	1	4	1	3	1	2	3	1	2	2	3	1	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:59224764G>T	uc010rku.1	+	1	331	c.331G>T	c.(331-333)GAT>TAT	p.D111Y		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGGTGGGGCAGATATTTTTTT	0.483													50	139					3.76525e-18	4.43105e-18	1	0	T	59224764	T	T	59224764	3	4	215	1	0	0	0	0	1	0	0	0	11112	942	33	2	333	2	OR4D6	11	59224764	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	3320219	59224764	75781752	83	39638											
MEN1	4221	broad.mit.edu	37	chr11	64577227	64577227	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgacatcggagaccttctTcaccagctcacggctggaga	10	9	10	12	2	3	3	2	1	1	2	4	5	3	3	2	3	1	2	2	3	1	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:64577227T>A	uc001obj.2	-	2	428	c.355A>T	c.(355-357)AAG>TAG	p.K119*	MEN1_uc001obk.2_Nonsense_Mutation_p.K119*|MEN1_uc001obl.2_Nonsense_Mutation_p.K119*|MEN1_uc001obm.2_Nonsense_Mutation_p.K119*|MEN1_uc001obn.2_Nonsense_Mutation_p.K119*|MEN1_uc001obo.2_Nonsense_Mutation_p.K119*|MEN1_uc001obp.2_Nonsense_Mutation_p.K119*|MEN1_uc001obq.2_Nonsense_Mutation_p.K119*|MEN1_uc001obr.2_Nonsense_Mutation_p.K119*	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	119			Missing (in MEN1).		DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding	p.K119del(3)|p.S114fs*60(1)		parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						GAGACCTTCTTCACCAGCTCA	0.612			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				55	47					0	0	0	0	A	64577227	A	A	64577227	4	1	215	1	0	0	0	0	0	1	0	0	9525	1792	62	5	1528	5	MEN1	11	64577227	Nonsense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08	5352463	64577227	70429289	84	39639											
WNT11	7481	broad.mit.edu	37	chr11	75907652	75907652	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgcaccaccgtgtgcatgAgctccaggttgctgcggcac	6	8	13	14	3	0	1	0	1	0	0	1	1	1	1	3	2	5	6	3	2	0	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:75907652A>G	uc001oxe.2	-	2	317	c.194T>C	c.(193-195)CTC>CCC	p.L65P	WNT11_uc001oxf.1_Missense_Mutation_p.L65P	NM_004626	NP_004617	O96014	WNT11_HUMAN	wingless-type MMTV integration site family,	65					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			lung(1)|skin(1)	2						CGTGTGCATGAGCTCCAGGTT	0.647													40	26					0	0	0	0	G	75907652	G	G	75907652	3	3	215	1	0	0	0	0	1	0	0	0	17452	304	11	5	886	5	WNT11	11	75907652	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	11330425	75907652	59098864	85	39640											
PCF11	51585	broad.mit.edu	37	chr11	82881002	82881002	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actttggcaatatacctgctCcaatgacagtaggaaatatt	14	12	7	8	0	0	1	0	1	0	0	1	2	1	2	2	2	2	3	2	2	7	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:82881002C>A	uc001ozx.3	+	8	3970	c.3625C>A	c.(3625-3627)CCA>ACA	p.P1209T	PCF11_uc010rsu.1_Missense_Mutation_p.P1340T	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	1209					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						TATACCTGCTCCAATGACAGT	0.348													12	14					3.07112e-06	3.36776e-06	1	0	A	82881002	A	A	82881002	3	1	215	1	0	0	0	0	1	0	0	0	11627	855	30	2	3655	2	PCF11	11	82881002	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	6973350	82881002	52125514	86	39641											
CCDC89	220388	broad.mit.edu	37	chr11	85396180	85396180	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggatcccatctactttgcGctgaagctccctgactctca	7	12	7	15	1	2	2	1	2	2	0	5	3	4	3	2	1	3	2	2	1	2	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:85396180G>A	uc001pau.1	-	1	1141	c.994C>T	c.(994-996)CGC>TGC	p.R332C		NM_152723	NP_689936	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	332	Potential.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TCTACTTTGCGCTGAAGCTCC	0.498													23	71					0	0	0	0	A	85396180	A	A	85396180	3	1	215	1	0	0	0	0	1	0	0	0	2879	1087	38	1	134	1	CCDC89	11	85396180	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	2515178	85396180	49610336	87	39642											
ANKK1	255239	broad.mit.edu	37	chr11	113266828	113266828	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tattatccgagtggcggcagGcatgcggccctccctacagc	7	8	12	14	3	0	0	0	0	0	0	2	1	2	0	3	4	3	2	3	4	3	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:113266828G>C	uc001pny.2	+	5	816	c.722G>C	c.(721-723)GGC>GCC	p.G241A		NM_178510	NP_848605	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	241	Protein kinase.						ATP binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|ovary(1)|breast(1)	8		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		GTGGCGGCAGGCATGCGGCCC	0.597													22	52					0	0	0	0	C	113266828	C	C	113266828	3	2	215	1	0	0	0	0	1	0	0	0	631	1203	42	4	740	4	ANKK1	11	113266828	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	27870648	113266828	21739688	88	39643											
OR8B4	283162	broad.mit.edu	37	chr11	124294456	124294456	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cactcagaattgacaaagaaAcagaagaaaaatagctgagt	21	6	8	6	0	1	6	1	2	0	4	1	6	1	6	0	0	2	1	0	0	7	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr11:124294456A>C	uc010sak.1	-	1	312	c.312T>G	c.(310-312)TGT>TGG	p.C104W		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGACAAAGAAACAGAAGAAAA	0.423													16	51					0	0	0	0	C	124294456	C	C	124294456	3	2	215	1	0	0	0	0	1	0	0	0	11283	41	2	5	619	5	OR8B4	11	124294456	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	11027628	124294456	10712060	89	39644											
PRB3	5544	broad.mit.edu	37	chr12	11421068	11421068	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcctccttgtgggcgtcGtccttctggctttcctggag	1	16	12	12	2	1	0	0	0	1	0	6	1	5	1	4	3	0	2	4	3	0	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr12:11421068G>A	uc001qzs.2	-	3	153	c.115C>T	c.(115-117)CGA>TGA	p.R39*	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	39	Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TGTGGGCGTCGTCCTTCTGGC	0.547													57	92					0	0	0	0	A	11421068	A	A	11421068	4	1	215	1	0	0	0	0	0	1	0	0	12506	1153	40	1	822	1	PRB3	12	11421068	Nonsense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08		11421068	122430827	90	39645											
NELL2	4753	broad.mit.edu	37	chr12	44917184	44917184	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaattctttccatgaggacAtcgacaatcatatccgccat	12	11	6	12	2	2	1	1	1	1	0	5	3	4	2	3	1	0	1	3	1	3	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr12:44917184A>T	uc001rog.2	-	17	2483	c.1888T>A	c.(1888-1890)TGT>AGT	p.C630S	NELL2_uc001rof.3_Missense_Mutation_p.C629S|NELL2_uc001roh.2_Missense_Mutation_p.C630S|NELL2_uc009zkd.2_Missense_Mutation_p.C582S|NELL2_uc010skz.1_Missense_Mutation_p.C680S|NELL2_uc010sla.1_Missense_Mutation_p.C653S|NELL2_uc001roi.1_Missense_Mutation_p.C630S	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	630	EGF-like 6; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		CCATGAGGACATCGACAATCA	0.448													30	92					0	0	0	0	T	44917184	T	T	44917184	3	4	215	1	0	0	0	0	1	0	0	0	10388	217	8	5	578	5	NELL2	12	44917184	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	33496116	44917184	88934711	91	39646											
ESPL1	9700	broad.mit.edu	37	chr12	53662897	53662897	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgccatcctgagggcttgCaaccagcagctgactgctaa	10	8	11	12	0	0	2	0	2	0	0	1	3	1	2	3	1	6	5	3	1	2	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr12:53662897C>A	uc001sck.2	+	3	262	c.171C>A	c.(169-171)TGC>TGA	p.C57*	ESPL1_uc001scj.2_5'UTR	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	57					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						TGAGGGCTTGCAACCAGCAGC	0.572													40	31					1.96642e-18	2.34271e-18	1	0	A	53662897	A	A	53662897	4	1	215	1	0	0	0	0	0	1	0	0	5277	718	25	4	177	4	ESPL1	12	53662897	Nonsense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	8745713	53662897	80188998	92	39647											
SRGAP1	57522	broad.mit.edu	37	chr12	64505580	64505580	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgagaatatgatggacccttAtaacctggccatttgctttg	10	14	9	8	0	0	2	0	2	0	1	0	4	0	3	3	2	2	1	3	2	4	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr12:64505580A>G	uc010ssp.1	+	17	2014	c.1958A>G	c.(1957-1959)TAT>TGT	p.Y653C	SRGAP1_uc001srv.2_Missense_Mutation_p.Y590C	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	653	Rho-GAP.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		ATGGACCCTTATAACCTGGCC	0.378													21	55					0	0	0	0	G	64505580	G	G	64505580	3	3	215	1	0	0	0	0	1	0	0	0	15211	449	16	5	2024	5	SRGAP1	12	64505580	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	10842683	64505580	69346315	93	39648											
TMPO	7112	broad.mit.edu	37	chr12	98931317	98931317	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcagagcaaagactccagtAacactcaagcaaagaagagt	18	4	10	9	0	1	4	1	0	0	4	2	4	2	4	1	1	3	4	1	1	5	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr12:98931317A>T	uc001tfj.2	+	4	867	c.630A>T	c.(628-630)GTA>GTT	p.V210V	TMPO_uc001tfi.1_Silent_p.V210V|TMPO_uc001tfk.2_Silent_p.V210V|TMPO_uc001tfl.2_RNA	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta	210	Nucleoplasmic (Potential).|NAKAP95-binding N.					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2						AGACTCCAGTAACACTCAAGC	0.388													7	14					0	0	0	0	T	98931317	T	T	98931317	2	4	215	1	0	0	0	0	0	0	0	1	16303	349	13	5		5	TMPO	12	98931317	Silent	SNP	A	TCGA-CV-6962-01A-11D-1912-08	34425737	98931317	34920578	94	39649											
GIT2	9815	broad.mit.edu	37	chr12	110427583	110427583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccatatagagttagcacCgttattatacaaggtctcaa	13	12	6	10	1	1	1	1	0	1	1	3	1	2	1	2	1	2	3	2	1	8	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr12:110427583C>T	uc001tps.2	-	3	376	c.211G>A	c.(211-213)GGT>AGT	p.G71S	GIT2_uc001tpq.2_Missense_Mutation_p.G71S|GIT2_uc001tpv.2_Missense_Mutation_p.G71S|GIT2_uc001tpu.2_Missense_Mutation_p.G71S|GIT2_uc001tpt.2_Missense_Mutation_p.G71S|GIT2_uc010sxu.1_Missense_Mutation_p.G9S|GIT2_uc001tpw.2_Missense_Mutation_p.G71S|GIT2_uc010sxv.1_Missense_Mutation_p.G71S	NM_057169	NP_476510	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting	71	Arf-GAP.				regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			central_nervous_system(1)	1						GAGTTAGCACCGTTATTATAC	0.398													20	47					0	0	0	0	T	110427583	T	T	110427583	3	4	215	1	0	0	0	0	1	0	0	0	6434	652	23	1	2178	1	GIT2	12	110427583	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	11496266	110427583	23424312	95	39650											
RIMBP2	23504	broad.mit.edu	37	chr12	130892304	130892304	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgggcgagctttctctgggGtcgtagtcatacagggccac	6	11	14	10	2	2	0	1	0	1	0	4	1	2	0	1	4	2	2	1	4	2	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr12:130892304G>T	uc001uil.2	-	16	3056	c.2892C>A	c.(2890-2892)GAC>GAA	p.D964E		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	964	SH3 3.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TTTCTCTGGGGTCGTAGTCAT	0.552													109	218					4.95557e-46	6.5063e-46	1	0	T	130892304	T	T	130892304	3	4	215	1	0	0	0	0	1	0	0	0	13428	1252	44	4	282	4	RIMBP2	12	130892304	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	20464721	130892304	2959591	96	39651											
EP400	57634	broad.mit.edu	37	chr12	132491260	132491260	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcaggtcaagtttaatgctCcatctttgttgtatggggct	7	16	11	7	0	2	0	1	0	1	0	3	0	3	0	1	3	2	6	1	3	3	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr12:132491260C>T	uc001ujn.2	+	14	3177	c.3142C>T	c.(3142-3144)CCA>TCA	p.P1048S	EP400_uc001ujl.2_Missense_Mutation_p.P1047S|EP400_uc001ujm.2_Missense_Mutation_p.P1048S	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1084	Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GTTTAATGCTCCATCTTTGTT	0.398													20	21					0	0	0	0	T	132491260	T	T	132491260	3	4	215	1	0	0	0	0	1	0	0	0	5173	855	30	2	3193	2	EP400	12	132491260	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	1598956	132491260	1360635	97	39652											
LIG4	3981	broad.mit.edu	37	chr13	108861972	108861972	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagaattacaaggttcaaTgtatacttctggcttctctg	11	14	8	8	0	3	1	1	0	2	1	4	2	3	1	0	2	2	3	0	2	6	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr13:108861972T>A	uc001vqn.2	-	2	1918	c.1645A>T	c.(1645-1647)ATT>TTT	p.I549F	LIG4_uc001vqo.2_Missense_Mutation_p.I549F|LIG4_uc010agg.1_Missense_Mutation_p.I482F|LIG4_uc010agf.2_Missense_Mutation_p.I549F|LIG4_uc001vqp.2_Missense_Mutation_p.I549F	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	549					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					CAAGGTTCAATGTATACTTCT	0.403								NHEJ					34	13					0	0	0	0	A	108861972	A	A	108861972	3	1	215	1	0	0	0	0	1	0	0	0	8824	1464	51	5	1094	5	LIG4	13	108861972	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08		108861972	6307906	98	39653											
DHRS4L2	317749	broad.mit.edu	37	chr14	24464313	24464313	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	accctttctttggaagcctaAtggatgtcaccgaggaggtg	9	11	12	9	1	2	0	1	0	1	0	2	4	2	3	3	4	1	0	3	4	2	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr14:24464313A>C	uc001wli.3	+	3	509	c.379A>C	c.(379-381)ATG>CTG	p.M127L	DHRS4_uc001wlc.3_Intron|DHRS4L2_uc001wld.3_Intron|DHRS4L2_uc001wle.3_Intron|DHRS4L2_uc001wlg.3_RNA|DHRS4L2_uc001wlh.3_Intron|DHRS4L2_uc010tnt.1_Intron|DHRS4L2_uc010alb.2_Missense_Mutation_p.M1L	NM_198083	NP_932349	D5KJA1	D5KJA1_HUMAN	dehydrogenase/reductase (SDR family) member 4	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							binding|oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00962)		TGGAAGCCTAATGGATGTCAC	0.522													9	659					0	0	0	0	C	24464313	C	C	24464313	3	2	215	1	0	0	0	0	1	0	0	0	4516	101	4	5	389	5	DHRS4L2	14	24464313	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08		24464313	82885227	99	39654											
RALGAPA1	253959	broad.mit.edu	37	chr14	36207835	36207835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actggaatttcgaacatgatCagcagtattggtcccatttt	11	14	8	8	1	1	1	1	1	0	0	3	3	2	2	1	2	2	2	1	2	3	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr14:36207835C>T	uc001wti.2	-	12	1862	c.1471G>A	c.(1471-1473)GAT>AAT	p.D491N	RALGAPA1_uc001wtj.2_Missense_Mutation_p.D491N|RALGAPA1_uc010tpv.1_Missense_Mutation_p.D491N|RALGAPA1_uc010tpw.1_Missense_Mutation_p.D491N|RALGAPA1_uc001wtk.1_Missense_Mutation_p.D342N	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	491					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						CGAACATGATCAGCAGTATTG	0.388													5	133					0	0	0	0	T	36207835	T	T	36207835	3	4	215	1	0	0	0	0	1	0	0	0	13078	826	29	2	4908	2	RALGAPA1	14	36207835	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	11743522	36207835	71141705	100	39655											
DCAF4	26094	broad.mit.edu	37	chr14	73404779	73404779	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctccgtgattctgaagacagGcaagtgtgccgctctgggga	8	9	14	10	2	2	3	0	2	2	1	3	4	3	4	2	3	1	2	2	3	2	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr14:73404779G>A	uc001xng.2	+	2	312	c.92_splice	c.e2+1	p.R31_splice	DCAF4_uc001xnj.2_Splice_Site_p.R31_splice|DCAF4_uc010ttr.1_Splice_Site_p.G20_splice|DCAF4_uc001xnh.2_Intron|DCAF4_uc010tts.1_Splice_Site_p.R31_splice|DCAF4_uc010ttt.1_Splice_Site|DCAF4_uc001xni.2_Splice_Site_p.R31_splice|DCAF4_uc001xnk.2_Splice_Site_p.R31_splice	NM_015604	NP_056419	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4 isoform 1							CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)|skin(1)	3						CTGAAGACAGGCAAGTGTGCC	0.483													64	33					0	0	0	0	A	73404779	A	A	73404779	5	1	215	1	0	0	0	0	0	0	1	0	4287	1217	42	4	95	4	DCAF4	14	73404779	Splice_Site	SNP	G	TCGA-CV-6962-01A-11D-1912-08	37196944	73404779	33944761	101	39656											
SERPINA9	327657	broad.mit.edu	37	chr14	94942687	94942687	+	5'Flank	DEL	C	-	-																															tgatatattatttttattctCcagctcaatcctttcctctg																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr14:94942687delC	uc001ydf.2	-						SERPINA9_uc001yde.2_5'Flank|SERPINA9_uc010avc.2_5'Flank|SERPINA9_uc001ydg.2_5'Flank|SERPINA9_uc001ydh.1_5'Flank|SERPINA9_uc001ydi.1_5'Flank	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade						regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		tttttattctccagctcaatc	0													---	---	---								-	94942687	-	-	94942687	6	5	215	0	1	1	0	1	0	0	0	0	14160	870	30	0		0	SERPINA9	14	94942687	5'Flank	DEL	C	TCGA-CV-6962-01A-11D-1912-08	21537908	94942687	12406853	102	39657											
PPP2R5C	5527	broad.mit.edu	37	chr14	102391561	102391561	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccacaccaagaaagccttGgaagctcactgcagggccga	12	4	10	15	1	1	1	1	0	0	1	1	3	1	2	5	2	3	2	5	2	3	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr14:102391561G>C	uc001yko.2	+	14	1667	c.1527G>C	c.(1525-1527)TTG>TTC	p.L509F	PPP2R5C_uc010txr.1_Missense_Mutation_p.L540F|PPP2R5C_uc001ykk.2_Missense_Mutation_p.L525F|PPP2R5C_uc001ykp.2_Missense_Mutation_p.L470F	NM_002719	NP_002710	Q13362	2A5G_HUMAN	gamma isoform of regulatory subunit B56, protein	509					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein binding|protein phosphatase type 2A regulator activity|protein phosphatase type 2A regulator activity			ovary(1)|breast(1)	2						AGAAAGCCTTGGAAGCTCACT	0.493													64	27					0	0	0	0	C	102391561	C	C	102391561	3	2	215	1	0	0	0	0	1	0	0	0	12454	1339	47	4	1974	4	PPP2R5C	14	102391561	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	7448874	102391561	4957979	103	39658											
ISLR2	57611	broad.mit.edu	37	chr15	74425610	74425610	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccttcgacgcgcttagcgCgctgtcacacttgcaactct	7	10	8	16	5	2	0	1	0	1	0	3	1	2	0	1	0	3	3	1	0	2	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr15:74425610C>A	uc002axd.2	+	4	1284	c.515C>A	c.(514-516)GCG>GAG	p.A172E	ISLR2_uc002axe.2_Missense_Mutation_p.A172E|ISLR2_uc010bjg.2_Missense_Mutation_p.A172E|ISLR2_uc010bjf.2_Missense_Mutation_p.A172E	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	172	Extracellular (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						GCGCTTAGCGCGCTGTCACAC	0.667													81	10					1.15773e-35	1.50974e-35	1	0	A	74425610	A	A	74425610	3	1	215	1	0	0	0	0	1	0	0	0	7898	768	27	3	517	3	ISLR2	15	74425610	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08		74425610	28105782	104	39659											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84582032	84582032	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcatgtgatgagagcccggCctcccgagagctagacatcc	10	6	12	13	2	0	4	0	2	0	3	2	6	2	4	4	1	3	2	4	1	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr15:84582032C>A	uc002bjz.3	+	16	2113	c.1889C>A	c.(1888-1890)GCC>GAC	p.A630D	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.A630D|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.A630D	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	630						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GAGAGCCCGGCCTCCCGAGAG	0.612													58	14					6.60958e-23	8.17724e-23	1	0	A	84582032	A	A	84582032	3	1	215	1	0	0	0	0	1	0	0	0	276	739	26	4	1947	4	ADAMTSL3	15	84582032	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	10156422	84582032	17949360	105	39660											
AXIN1	8312	broad.mit.edu	37	chr16	343545	343545	+	Missense_Mutation	SNP	G	C	C																															cctcctccagacgtcggcgcGcctcctccagctgggttagg																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr16:343545G>C	uc002cgp.1	-	8	2306	c.2129C>G	c.(2128-2130)GCG>GGG	p.A710G	AXIN1_uc002cgq.1_Missense_Mutation_p.A710G	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	710	Interaction with RNF111.|Interaction with PPP2CA.|Interaction with HIPK2 (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				ACGTCGGCGCGCCTCCTCCAG	0.667													81	24					0	0	0	0	C	343545	C	C	343545	3	2	215	1	0	0	0	0	1	0	0	0	1238	1087	38	3	475	3	AXIN1	16	343545	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08		343545	90011208	106	39661	80	2									
AXIN1	8312	broad.mit.edu	37	chr16	343549	343549	+	Missense_Mutation	SNP	C	T	T																															ctccagacgtcggcgcgcctCctccagctgggttagggggt																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr16:343549C>T	uc002cgp.1	-	8	2302	c.2125G>A	c.(2125-2127)GAG>AAG	p.E709K	AXIN1_uc002cgq.1_Missense_Mutation_p.E709K	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	709	Interaction with RNF111.|Interaction with PPP2CA.|Interaction with HIPK2 (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CGGCGCGCCTCCTCCAGCTGG	0.677													86	25					0	0	0	0	T	343549	T	T	343549	3	4	215	1	0	0	0	0	1	0	0	0	1238	864	30	2	479	2	AXIN1	16	343549	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	4	343549	90011204	107	39662	80	2									
CREBBP	1387	broad.mit.edu	37	chr16	3788605	3788605	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atccaataaggatctcatggTaaacggctgtgcggaggcaa	13	8	12	8	2	1	0	1	0	1	0	3	2	2	2	1	5	2	3	1	5	5	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr16:3788605T>C	uc002cvv.2	-	26	4553	c.4349A>G	c.(4348-4350)TAC>TGC	p.Y1450C	CREBBP_uc002cvw.2_Missense_Mutation_p.Y1412C	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1450	Cys/His-rich.		Y -> H (in RSTS1).		cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.Y1450C(1)		haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GATCTCATGGTAAACGGCTGT	0.398			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				20	3					0	0	0	0	C	3788605	C	C	3788605	3	2	215	1	0	0	0	0	1	0	0	0	3876	1638	57	5	3003	5	CREBBP	16	3788605	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08	3445056	3788605	86566148	108	39663											
VWA3A	146177	broad.mit.edu	37	chr16	22134933	22134933	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtggcccacacttctgcaGcaacagctcagcagagctat	10	8	9	14	0	2	1	1	0	1	1	2	1	2	1	1	1	6	5	1	1	2	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr16:22134933G>T	uc010vbq.1	+	16	1534	c.1438_splice	c.e16-1	p.Q480_splice	VWA3A_uc010bxd.2_Splice_Site|VWA3A_uc010bxc.2_Splice_Site_p.Q488_splice	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A							extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		CACTTCTGCAGCAACAGCTCA	0.572													38	85					2.35968e-33	3.0565e-33	1	0	T	22134933	T	T	22134933	5	4	215	1	0	0	0	0	0	0	1	0	17308	985	34	4	1499	4	VWA3A	16	22134933	Splice_Site	SNP	G	TCGA-CV-6962-01A-11D-1912-08	18346328	22134933	68219820	109	39664											
SCNN1B	6338	broad.mit.edu	37	chr16	23391989	23391989	+	Frame_Shift_Del	DEL	G	-	-																															ccagcctgacacggccccccGcagccccaacactgggccct																								rs140945152		TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr16:23391989delG	uc002dln.2	+	13	1966	c.1790delG	c.(1789-1791)CGCfs	p.R597fs		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	597	Cytoplasmic (By similarity).		R -> H.		excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	ACGGCCCCCCGCAGCCCCAAC	0.711													---	---	---								-	23391989	-	-	23391989	7	5	215	1	0	1	0	1	0	0	0	0	13993	1087	38	0	1836	0	SCNN1B	16	23391989	Frame_Shift_Del	DEL	G	TCGA-CV-6962-01A-11D-1912-08	1257056	23391989	66962764	110	39665											
PALB2	79728	broad.mit.edu	37	chr16	23646401	23646401	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcagtgggcccagcgggaGagctgactttagttaatgag	9	10	14	8	1	1	3	1	2	0	1	1	4	1	3	1	2	2	2	1	2	2	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr16:23646401G>A	uc002dlx.1	-	4	1666	c.1466C>T	c.(1465-1467)TCT>TTT	p.S489F		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	489					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		CCCAGCGGGAGAGCTGACTTT	0.468			F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				21	163					0	0	0	0	A	23646401	A	A	23646401	3	1	215	1	0	0	0	0	1	0	0	0	11460	942	33	2	2134	2	PALB2	16	23646401	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	254412	23646401	66708352	111	39666											
LAT	27040	broad.mit.edu	37	chr16	29000849	29000849	+	Frame_Shift_Del	DEL	G	-	-																															gggcctggcttttccacagtGgagtccattgatgattacgt																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr16:29000849delG	uc002dsd.2	+	8	934	c.582delG	c.(580-582)ATGfs	p.M194fs	uc010vct.1_Intron|LAT_uc010vdj.1_Frame_Shift_Del_p.M201fs|LAT_uc002dsb.2_Frame_Shift_Del_p.M165fs|LAT_uc002dsc.2_Frame_Shift_Del_p.M164fs|LAT_uc010vdk.1_Frame_Shift_Del_p.M155fs|LAT_uc010vdl.1_Frame_Shift_Del_p.M193fs	NM_014387	NP_055202	O43561	LAT_HUMAN	linker for activation of T cells isoform a	194	Cytoplasmic (Potential).				calcium-mediated signaling|integrin-mediated signaling pathway|mast cell degranulation|platelet activation|Ras protein signal transduction|regulation of T cell activation|T cell receptor signaling pathway	immunological synapse|integral to membrane|intracellular|membrane raft	SH3/SH2 adaptor activity				0		Hepatocellular(780;0.244)				TTTCCACAGTGGAGTCCATTG	0.622													---	---	---								-	29000849	-	-	29000849	7	5	215	1	0	1	0	1	0	0	0	0	8684	1362	47	0	724	0	LAT	16	29000849	Frame_Shift_Del	DEL	G	TCGA-CV-6962-01A-11D-1912-08	5354448	29000849	61353904	112	39667											
HP	3240	broad.mit.edu	37	chr16	72094177	72094178	+	Frame_Shift_Del	DEL	TC	-	-																															ctgctgaccacggctaaaaaTctcttcctgaaccattcaga																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr16:72094177_72094178delTC	uc002fbr.3	+	7	653_654	c.609_610delTC	c.(607-612)AATCTCfs	p.N203fs	TXNL4B_uc010cgl.2_Intron|HP_uc010cgm.2_Frame_Shift_Del_p.N144fs|HP_uc002fbt.3_Frame_Shift_Del_p.N144fs|HP_uc002fbu.1_5'UTR|HP_uc002fbv.3_Frame_Shift_Del_p.N114fs|HP_uc002fbw.3_Frame_Shift_Del_p.N25fs|HP_uc002fbx.3_Frame_Shift_Del_p.N25fs|HPR_uc002fby.2_5'Flank	NM_005143	NP_005134	P00738	HPT_HUMAN	haptoglobin isoform 1 preproprotein	203_204	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity				0		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		CGGCTAAAAATCTCTTCCTGAA	0.465													---	---	---								-	72094178	-	-	72094177	7	5	215	1	0	1	0	1	0	0	0	0	7366	1432	50	0	635	0	HP	16	72094177	Frame_Shift_Del	DEL	TC	TCGA-CV-6962-01A-11D-1912-08	43093328	72094177	18260576	113	39668											
TAF1C	9013	broad.mit.edu	37	chr16	84214963	84214963	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcatcttcactccggtgcGgtcacccacggtcagcaccc	7	7	9	18	3	4	0	3	0	1	0	5	0	5	0	3	3	3	2	3	3	0	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr16:84214963G>A	uc002fhn.2	-	10	1441	c.1213C>T	c.(1213-1215)CGC>TGC	p.R405C	TAF1C_uc002fhm.2_Missense_Mutation_p.R312C|TAF1C_uc010vnx.1_Missense_Mutation_p.R379C|TAF1C_uc010vny.1_5'UTR|TAF1C_uc010vnz.1_Missense_Mutation_p.R73C|TAF1C_uc002fho.2_5'UTR|TAF1C_uc010voa.1_Missense_Mutation_p.R73C|TAF1C_uc002fhp.1_Intron|TAF1C_uc010vob.1_3'UTR	NM_005679	NP_005670	Q15572	TAF1C_HUMAN	TBP-associated factor 1C isoform 1	405					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			ovary(1)	1						ACTCCGGTGCGGTCACCCACG	0.667													15	4					0	0	0	0	A	84214963	A	A	84214963	3	1	215	1	0	0	0	0	1	0	0	0	15587	1116	39	1	1416	1	TAF1C	16	84214963	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	12120786	84214963	6139790	114	39669											
MYO1C	4641	broad.mit.edu	37	chr17	1386944	1386944	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagctgacgccacggtaacGctccatatgctgccggctgt	8	8	12	13	4	0	1	0	1	0	0	1	2	1	1	3	2	4	5	3	2	3	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:1386944G>A	uc002fsp.2	-	3	527	c.307C>T	c.(307-309)CGT>TGT	p.R103C	MYO1C_uc002fsn.2_Missense_Mutation_p.R84C|MYO1C_uc002fso.2_Missense_Mutation_p.R68C|MYO1C_uc010vqj.1_Missense_Mutation_p.R68C|MYO1C_uc010vqk.1_Missense_Mutation_p.R79C	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	103	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCACGGTAACGCTCCATATGC	0.627													6	13					0	0	0	0	A	1386944	A	A	1386944	3	1	215	1	0	0	0	0	1	0	0	0	10123	1087	38	1	3004	1	MYO1C	17	1386944	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08		1386944	79808266	115	39670											
ATP2A3	489	broad.mit.edu	37	chr17	3854894	3854894	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctgccacacgcccacaatgGcgttggccacgaggatcagc	9	5	11	16	3	1	0	1	0	0	0	1	2	1	1	4	3	2	1	4	3	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:3854894G>A	uc002fxb.1	-	4	456	c.305C>T	c.(304-306)GCC>GTC	p.A102V	ATP2A3_uc002fwx.1_Missense_Mutation_p.A102V|ATP2A3_uc002fwy.1_Missense_Mutation_p.A102V|ATP2A3_uc002fwz.1_Missense_Mutation_p.A102V|ATP2A3_uc002fxa.1_Missense_Mutation_p.A102V|ATP2A3_uc002fxc.1_Missense_Mutation_p.A102V|ATP2A3_uc002fxd.1_Missense_Mutation_p.A102V	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	102	Helical; Name=2; (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GCCCACAATGGCGTTGGCCAC	0.687													10	12					0	0	0	0	A	3854894	A	A	3854894	3	1	215	1	0	0	0	0	1	0	0	0	1140	1203	42	4	2977	4	ATP2A3	17	3854894	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	2467950	3854894	77340316	116	39671											
TP53	7157	broad.mit.edu	37	chr17	7578271	7578271	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccttccactcggataagaTgctgaggaggggccagacct	9	9	12	11	1	0	3	0	1	0	2	3	5	2	5	4	4	1	1	4	4	1	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:7578271T>C	uc002gim.2	-	6	772	c.578A>G	c.(577-579)CAT>CGT	p.H193R	TP53_uc002gig.1_Missense_Mutation_p.H193R|TP53_uc002gih.2_Missense_Mutation_p.H193R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H61R|TP53_uc010cng.1_Missense_Mutation_p.H61R|TP53_uc002gii.1_Missense_Mutation_p.H61R|TP53_uc010cnh.1_Missense_Mutation_p.H193R|TP53_uc010cni.1_Missense_Mutation_p.H193R|TP53_uc002gij.2_Missense_Mutation_p.H193R|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100R|TP53_uc002gio.2_Missense_Mutation_p.H61R|TP53_uc010vug.1_Missense_Mutation_p.H154R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	193	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> D (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(67)|p.H193L(31)|p.H193Y(26)|p.H193P(12)|p.0?(7)|p.H193D(7)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.H193H(2)|p.P191fs*53(2)|p.K164_P219del(1)|p.P191fs*15(1)|p.P191fs*6(1)|p.H100L(1)|p.H61L(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	8					0	0	0	0	C	7578271	C	C	7578271	3	2	215	1	0	0	0	0	1	0	0	0	16448	1464	51	5	716	5	TP53	17	7578271	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08	3723377	7578271	73616939	117	39672											
C17orf68	80169	broad.mit.edu	37	chr17	8138161	8138161	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagaagatccagggtaggaGccaggagttgcagtcccagg	11	6	15	9	0	0	2	0	0	0	2	2	4	2	4	3	4	2	3	3	4	3	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:8138161G>A	uc002gkq.3	-	9	1582	c.1523C>T	c.(1522-1524)GCT>GTT	p.A508V	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	508					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						CAGGGTAGGAGCCAGGAGTTG	0.567													51	84					0	0	0	0	A	8138161	A	A	8138161	3	1	215	1	0	0	0	0	1	0	0	0	1883	971	34	4	2190	4	C17orf68	17	8138161	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	559890	8138161	73057049	118	39673											
KCNJ12	3768	broad.mit.edu	37	chr17	21319078	21319078	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctccatcgagacgcagAccaccatcggctacgggctg	8	8	10	15	4	2	2	0	0	2	2	5	3	2	2	3	2	1	3	3	2	1	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:21319078A>T	uc002gyv.1	+	3	1129	c.424A>T	c.(424-426)ACC>TCC	p.T142S		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	142				T -> N (in Ref. 2; AAC50615).	blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CGAGACGCAGACCACCATCGG	0.657										Prostate(3;0.18)			13	63					0	0	0	0	T	21319078	T	T	21319078	3	4	215	1	0	0	0	0	1	0	0	0	8085	275	10	5	426	5	KCNJ12	17	21319078	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	13180917	21319078	59876132	119	39674											
SLC6A4	6532	broad.mit.edu	37	chr17	28534763	28534763	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aactcaccaggagaaacagaGggctgatggccacccagcag	14	3	12	12	0	1	3	1	1	0	2	1	4	1	3	3	3	3	2	3	3	2	0			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:28534763G>C	uc002hey.3	-	13	2181	c.1637C>G	c.(1636-1638)CCT>CGT	p.P546R	SLC6A4_uc010csg.2_RNA	NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	546	Helical; Name=11; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	GAGAAACAGAGGGCTGATGGC	0.512													13	32					0	0	0	0	C	28534763	C	C	28534763	3	2	215	1	0	0	0	0	1	0	0	0	14750	1000	35	4	267	4	SLC6A4	17	28534763	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	7215685	28534763	52660447	120	39675											
C17orf75	64149	broad.mit.edu	37	chr17	30668273	30668273	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtgccacttgggcttccGtcctcactgtcccctcgttg	2	15	9	15	2	1	0	1	0	0	0	5	0	4	0	5	1	1	2	5	1	0	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:30668273G>A	uc002hhg.2	-	2	202	c.171C>T	c.(169-171)GAC>GAT	p.D57D		NM_022344	NP_071739	Q9HAS0	NJMU_HUMAN	hypothetical protein LOC64149	57					spermatogenesis					ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			TTGGGCTTCCGTCCTCACTGT	0.478													93	148					0	0	0	0	A	30668273	A	A	30668273	2	1	215	1	0	0	0	0	0	0	0	1	1888	1136	40	1		1	C17orf75	17	30668273	Silent	SNP	G	TCGA-CV-6962-01A-11D-1912-08	2133510	30668273	50526937	121	39676											
TMEM132E	124842	broad.mit.edu	37	chr17	32963160	32963160	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcggcccagccctgggagCagccacaccatcctagccac	8	4	10	19	1	0	0	0	0	0	0	1	1	1	1	6	2	5	1	6	2	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:32963160C>G	uc002hif.2	+	9	2170	c.1842C>G	c.(1840-1842)AGC>AGG	p.S614R		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	614	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GCCCTGGGAGCAGCCACACCA	0.632													7	20					0	0	0	0	G	32963160	G	G	32963160	3	3	215	1	0	0	0	0	1	0	0	0	16114	709	25	4	1876	4	TMEM132E	17	32963160	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	2294887	32963160	48232050	122	39677											
GGNBP2	79893	broad.mit.edu	37	chr17	34912940	34912940	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcgacatggtatgcttaaGcaacaggatctaagtattgc	13	10	10	8	1	1	0	0	0	1	0	1	2	1	1	0	2	5	4	0	2	5	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:34912940G>C	uc002hnb.2	+	4	441	c.192G>C	c.(190-192)AAG>AAC	p.K64N	GGNBP2_uc002hna.2_Missense_Mutation_p.K64N	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	64					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GTATGCTTAAGCAACAGGATC	0.443													55	75					0	0	0	0	C	34912940	C	C	34912940	3	2	215	1	0	0	0	0	1	0	0	0	6396	962	34	4	202	4	GGNBP2	17	34912940	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	1949780	34912940	46282270	123	39678											
KRT32	3882	broad.mit.edu	37	chr17	39616390	39616390	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccctgggggcagggtgagCaaggcatgccaacagtgcgt	8	5	18	10	1	0	1	0	1	0	0	0	1	0	1	2	5	4	3	2	5	2	0			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:39616390C>A	uc002hwr.2	-	7	1380	c.1319G>T	c.(1318-1320)TGC>TTC	p.C440F		NM_002278	NP_002269	Q14532	K1H2_HUMAN	keratin 32	440	Tail.				epidermis development	intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000812)				GCAGGGTGAGCAAGGCATGCC	0.647													15	22					0.000422831	0.000448387	1	0	A	39616390	A	A	39616390	3	1	215	1	0	0	0	0	1	0	0	0	8507	710	25	4	31	4	KRT32	17	39616390	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	4703450	39616390	41578820	124	39679											
FAM134C	162427	broad.mit.edu	37	chr17	40734008	40734008	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggaggcccctgacaaggcCagctgaatcataccctggga	10	6	13	12	0	1	2	1	2	0	0	1	4	1	4	4	4	2	1	4	4	3	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:40734008C>A	uc002ial.2	-	9	1327	c.1224G>T	c.(1222-1224)CTG>CTT	p.L408L	FAM134C_uc010wgq.1_Silent_p.L208L|FAM134C_uc002iam.1_Silent_p.L208L|FAM134C_uc010cyk.1_Silent_p.L311L	NM_178126	NP_835227	Q86VR2	F134C_HUMAN	hypothetical protein LOC162427	408						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		CTGACAAGGCCAGCTGAATCA	0.622													27	47					2.79863e-10	3.17727e-10	1	0	A	40734008	A	A	40734008	2	1	215	1	0	0	0	0	0	0	0	1	5475	581	21	4		4	FAM134C	17	40734008	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08	1117618	40734008	40461202	125	39680											
GRN	2896	broad.mit.edu	37	chr17	42429495	42429495	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggactggagaagatgcctgCccgccgggcttccttatccc	6	9	12	14	2	0	2	0	0	0	2	2	4	2	3	5	3	2	1	5	3	2	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:42429495C>T	uc002igp.1	+	11	1511	c.1292C>T	c.(1291-1293)GCC>GTC	p.A431V	GRN_uc002igr.1_Missense_Mutation_p.A225V	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	431					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		AAGATGCCTGCCCGCCGGGCT	0.667													55	57					0	0	0	0	T	42429495	T	T	42429495	3	4	215	1	0	0	0	0	1	0	0	0	6843	739	26	4	1330	4	GRN	17	42429495	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	1695487	42429495	38765715	126	39681											
KIAA1267	284058	broad.mit.edu	37	chr17	44248899	44248899	+	Frame_Shift_Del	DEL	C	-	-																															gaagagtgcaattggtcataCcccccttcaagtccccagat																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:44248899delC	uc002ikb.2	-	1	696	c.611delG	c.(610-612)GGTfs	p.G204fs	KIAA1267_uc002ikc.2_Frame_Shift_Del_p.G204fs|KIAA1267_uc002ikd.2_Frame_Shift_Del_p.G204fs|KIAA1267_uc010dav.2_Frame_Shift_Del_p.G204fs	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	204						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				ATTGGTCATACCCCCCTTCAA	0.458													---	---	---								-	44248899	-	-	44248899	7	5	215	1	0	1	0	1	0	0	0	0	8258	507	18	0	2762	0	KIAA1267	17	44248899	Frame_Shift_Del	DEL	C	TCGA-CV-6962-01A-11D-1912-08	1819404	44248899	36946311	127	39682											
CACNA1G	8913	broad.mit.edu	37	chr17	48699024	48699024	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctctctccctgtctagatcCctctagctgagatggaggct	6	13	9	13	0	4	2	0	1	4	2	7	4	5	3	2	2	1	2	2	2	2	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:48699024C>A	uc002irk.1	+	35	6301	c.5929C>A	c.(5929-5931)CCT>ACT	p.P1977T	CACNA1G_uc002irj.1_Intron|CACNA1G_uc002irl.1_Intron|CACNA1G_uc002irm.1_Intron|CACNA1G_uc002irn.1_Intron|CACNA1G_uc002iro.1_Intron|CACNA1G_uc002irp.1_Intron|CACNA1G_uc002irq.1_Missense_Mutation_p.P1954T|CACNA1G_uc002irr.1_Intron|CACNA1G_uc002irs.1_Intron|CACNA1G_uc002irt.1_Intron|CACNA1G_uc002irv.1_Intron|CACNA1G_uc002irw.1_Missense_Mutation_p.P1906T|CACNA1G_uc002iru.1_Missense_Mutation_p.P1943T|CACNA1G_uc002irx.1_Intron|CACNA1G_uc002iry.1_Intron|CACNA1G_uc002irz.1_Intron|CACNA1G_uc002isa.1_Intron|CACNA1G_uc002isb.1_Intron|CACNA1G_uc002isc.1_Missense_Mutation_p.P1879T|CACNA1G_uc002isd.1_Intron|CACNA1G_uc002ise.1_Intron|CACNA1G_uc002isf.1_Intron|CACNA1G_uc002isg.1_Intron|CACNA1G_uc002ish.1_Intron|CACNA1G_uc002isi.1_Intron	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1977	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TGTCTAGATCCCTCTAGCTGA	0.562													13	28					9.31168e-06	1.004e-05	1	0	A	48699024	A	A	48699024	3	1	215	1	0	0	0	0	1	0	0	0	2556	623	22	4	6334	4	CACNA1G	17	48699024	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	4450125	48699024	32496186	128	39683											
STXBP4	252983	broad.mit.edu	37	chr17	53120624	53120624	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgtgattcttcagaagcaGatgaaatggaaaggctcaag	14	10	11	6	0	3	4	2	2	1	2	3	5	3	5	0	2	1	2	0	2	4	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:53120624G>A	uc002iuf.1	+	11	1090	c.883G>A	c.(883-885)GAT>AAT	p.D295N	STXBP4_uc010dcc.1_Missense_Mutation_p.D220N|STXBP4_uc010dcd.1_Missense_Mutation_p.D295N	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	295	Potential.					cytoplasm	calcium ion binding			ovary(1)	1						TTCAGAAGCAGATGAAATGGA	0.313													5	9					0	0	0	0	A	53120624	A	A	53120624	3	1	215	1	0	0	0	0	1	0	0	0	15421	942	33	2	917	2	STXBP4	17	53120624	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	4421600	53120624	28074586	129	39684											
APOH	350	broad.mit.edu	37	chr17	64224252	64224252	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atacgtaatctcttctcctgGctcatagaatgtttttaacg	10	16	6	9	2	3	1	1	0	2	1	5	1	3	1	1	1	2	3	1	1	5	7			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:64224252G>C	uc002jfn.3	-	2	186	c.127C>G	c.(127-129)CCA>GCA	p.P43A		NM_000042	NP_000033	P02749	APOH_HUMAN	apolipoprotein H precursor	43	Sushi 1.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding				0			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			TCTTCTCCTGGCTCATAGAAT	0.483													76	97					0	0	0	0	C	64224252	C	C	64224252	3	2	215	1	0	0	0	0	1	0	0	0	804	1203	42	4	938	4	APOH	17	64224252	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	11103628	64224252	16970958	130	39685											
CD300E	342510	broad.mit.edu	37	chr17	72613588	72613588	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtcacagagccggggccCttcagagacaaacagcctgg	11	4	12	14	1	2	2	2	0	0	2	2	3	2	2	4	3	3	0	4	3	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:72613588C>T	uc002jlb.1	-	2	98	c.57G>A	c.(55-57)ACG>ACA	p.T19T		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	19	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						AGCCGGGGCCCTTCAGAGACA	0.552													25	18					0	0	0	0	T	72613588	T	T	72613588	2	4	215	1	0	0	0	0	0	0	0	1	3013	680	24	4		4	CD300E	17	72613588	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08	8389336	72613588	8581622	131	39686											
SFRS2	6427	broad.mit.edu	37	chr17	74732524	74732524	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgactccgactccgggatcGgctgcggcgacgccgcctag	6	5	14	16	8	0	0	0	0	0	0	3	4	2	1	4	3	1	1	4	3	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr17:74732524G>C	uc002jsv.2	-	2	555	c.385C>G	c.(385-387)CGA>GGA	p.R129G	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Missense_Mutation_p.R129G|SFRS2_uc010wtg.1_Missense_Mutation_p.R117G|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	129	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						CTCCGGGATCGGCTGCGGCGA	0.547													12	85					0	0	0	0	C	74732524	C	C	74732524	3	2	215	1	0	0	0	0	1	0	0	0	14240	1124	39	3	284	3	SFRS2	17	74732524	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	2118936	74732524	6462686	132	39687											
ADCYAP1	116	broad.mit.edu	37	chr18	909477	909478	+	Frame_Shift_Del	DEL	CG	-	-																															ggcggcggcgcgggggacgaCgcggagccgctctccaagcg																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr18:909477_909478delCG	uc010dkg.2	+	5	491_492	c.372_373delCG	c.(370-375)GACGCGfs	p.D124fs	ADCYAP1_uc010dkh.2_Frame_Shift_Del_p.D124fs	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	124_125					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						CGGGGGACGACGCGGAGCCGCT	0.668													---	---	---								-	909478	-	-	909477	7	5	215	1	0	1	0	1	0	0	0	0	302	535	19	0	386	0	ADCYAP1	18	909477	Frame_Shift_Del	DEL	CG	TCGA-CV-6962-01A-11D-1912-08		909477	77167771	133	39688											
ZFP161	7541	broad.mit.edu	37	chr18	5291170	5291170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctcatgcttctttaagtctGgggcacggataaatgatttt	9	16	9	7	1	3	1	1	1	3	0	4	2	3	2	0	3	1	2	0	3	3	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr18:5291170G>A	uc002kmq.2	-	4	1198	c.1037C>T	c.(1036-1038)CCA>CTA	p.P346L	ZFP161_uc002kmr.2_Missense_Mutation_p.P346L|ZFP161_uc010dkp.2_Missense_Mutation_p.P346L	NM_003409	NP_003400	O43829	ZF161_HUMAN	zinc finger protein 161 homolog	346	C2H2-type 3.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P346S(1)		ovary(1)	1						CTTTAAGTCTGGGGCACGGAT	0.453													48	76					0	0	0	0	A	5291170	A	A	5291170	3	1	215	1	0	0	0	0	1	0	0	0	17707	1348	47	4	316	4	ZFP161	18	5291170	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	4381693	5291170	72786078	134	39689											
ABHD3	171586	broad.mit.edu	37	chr18	19239184	19239191	+	Frame_Shift_Del	DEL	GTTCAGTG	-	-																															tagtaattaaaaagtagccaGttcagtggtttttccaatga																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr18:19239184_19239191delGTTCAGTG	uc002ktl.2	-	6	922_929	c.782_789delCACTGAAC	c.(781-789)CCACTGAACfs	p.P261fs	ABHD3_uc002ktm.2_Frame_Shift_Del_p.P208fs|ABHD3_uc010xao.1_RNA|ABHD3_uc002ktk.2_Frame_Shift_Del_p.P66fs|ABHD3_uc002ktn.2_Frame_Shift_Del_p.P38fs	NM_138340	NP_612213	Q8WU67	ABHD3_HUMAN	alpha/beta hydrolase domain containing protein	261_263						integral to membrane	carboxylesterase activity			central_nervous_system(1)	1						AAAGTAGCCAGTTCAGTGGTTTTTCCAA	0.375													---	---	---								-	19239191	-	-	19239184	7	5	215	1	0	1	0	1	0	0	0	0	83	1020	36	0	456	0	ABHD3	18	19239184	Frame_Shift_Del	DEL	GTTCAGTG	TCGA-CV-6962-01A-11D-1912-08	13948014	19239184	58838064	135	39690											
TTC39C	125488	broad.mit.edu	37	chr18	21703803	21703803	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatggtttcttacagtttgtCagggagccactggtgatgtg	7	15	13	6	0	2	1	1	1	1	0	2	2	2	2	1	3	2	2	1	3	2	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr18:21703803C>T	uc002kuw.2	+	9	1644	c.1192C>T	c.(1192-1194)CAG>TAG	p.Q398*	TTC39C_uc002kuu.2_Nonsense_Mutation_p.Q337*	NM_001135993	NP_001129465	Q8N584	TT39C_HUMAN	tetratricopeptide repeat domain 39C isoform 1	398							binding			ovary(1)	1						TACAGTTTGTCAGGGAGCCAC	0.368													12	22					0	0	0	0	T	21703803	T	T	21703803	4	4	215	1	0	0	0	0	0	1	0	0	16777	827	29	2	1226	2	TTC39C	18	21703803	Nonsense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	2464619	21703803	56373445	136	39691											
SETBP1	26040	broad.mit.edu	37	chr18	42643322	42643322	+	Frame_Shift_Del	DEL	A	-	-																															aatgcatcgacctgcccagcAaaagaggccagaagcccagc																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr18:42643322delA	uc010dni.2	+	6	4746	c.4450delA	c.(4450-4452)AAAfs	p.K1484fs		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1484						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCTGCCCAGCAAAAGAGGCCA	0.637									Schinzel-Giedion_syndrome				---	---	---								-	42643322	-	-	42643322	7	5	215	1	0	1	0	1	0	0	0	0	14194	131	5	0	4661	0	SETBP1	18	42643322	Frame_Shift_Del	DEL	A	TCGA-CV-6962-01A-11D-1912-08	20939519	42643322	35433926	137	39692											
ARID3A	1820	broad.mit.edu	37	chr19	971943	971943	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaacaaaggaggcggcggcGgcggcggcagcagcagcaac	11	0	17	13	5	0	0	0	0	0	0	0	1	0	1	1	7	5	4	1	7	3	0			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:971943G>C	uc002lql.2	+	9	1950	c.1660G>C	c.(1660-1662)GGC>CGC	p.G554R		NM_005224	NP_005215	Q99856	ARI3A_HUMAN	AT rich interactive domain 3A (BRIGHT- like)	554	Gly-rich.|Important for cytoplasmic localization (By similarity).					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		Aggcggcggcggcggcggcag	0.547													16	47					0	0	0	0	C	971943	C	C	971943	3	2	215	1	0	0	0	0	1	0	0	0	916	1116	39	3	1690	3	ARID3A	19	971943	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08		971943	58157040	138	39693											
C19orf6	91304	broad.mit.edu	37	chr19	1011795	1011795	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcagcatggacacgctcagCgtctgcaaggggcgcgcagg	9	4	16	12	4	2	0	1	0	1	0	2	1	2	1	0	4	4	5	0	4	1	0			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	e7311353-3925-4bc6-96a7-86ad927a0ed1	g.chr19:1011795C>T	uc002lqr.1	-	7	1091	c.945G>A	c.(943-945)ACG>ACA	p.T315T	uc002lqp.1_5'Flank|C19orf6_uc002lqq.1_RNA|C19orf6_uc002lqs.1_Silent_p.T315T	NM_001033026	NP_001028198	Q4ZIN3	MBRL_HUMAN	membralin isoform 1	315	Helical; (Potential).					cytoplasm|integral to membrane				pancreas(2)|breast(1)	3		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.0252)|STAD - Stomach adenocarcinoma(1328;0.18)		ACACGCTCAGCGTCTGCAAGG	0.711													3	5					0	0	0	0	T	1011795	T	T	1011795	2	4	215	1	0	0	0	0	0	0	0	1	1950	755	27	1		1	C19orf6	19	1011795	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08	39852	1011795	58117188	139	39694											
S1PR4	8698	broad.mit.edu	37	chr19	3179935	3179935	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccagcatctccagcgtgcGgagcatctgaagttgcagtc	8	9	12	12	2	2	1	0	1	2	0	5	2	3	2	2	1	5	4	2	1	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:3179935G>A	uc002lxg.2	+	1	1170	c.1145G>A	c.(1144-1146)CGG>CAG	p.R382Q		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	382	Cytoplasmic (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						TCCAGCGTGCGGAGCATCTGA	0.652													50	55					0	0	0	0	A	3179935	A	A	3179935	3	1	215	1	0	0	0	0	1	0	0	0	13861	1116	39	1	1147	1	S1PR4	19	3179935	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	2168140	3179935	55949048	140	39695											
SH3GL1	6455	broad.mit.edu	37	chr19	4365608	4365608	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caccgtgttgagcatggtcaGcttagcccgcgaggctggga	7	8	15	11	3	1	1	1	1	0	0	1	3	1	2	2	3	3	4	2	3	1	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:4365608G>A	uc002maj.2	-	4	308	c.202C>T	c.(202-204)CTG>TTG	p.L68L	SH3GL1_uc002mak.2_Silent_p.L68L|SH3GL1_uc010xig.1_Intron	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	68	Required for dimerization upon membrane association (By similarity).|BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		AGCATGGTCAGCTTAGCCCGC	0.662			T	MLL	AL								40	47					0	0	0	0	A	4365608	A	A	4365608	2	1	215	1	0	0	0	0	0	0	0	1	14315	962	34	4		4	SH3GL1	19	4365608	Silent	SNP	G	TCGA-CV-6962-01A-11D-1912-08	1185673	4365608	54763375	141	39696											
HDGFRP2	84717	broad.mit.edu	37	chr19	4498321	4498321	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agagccctccgtggaggagaAgctgcagaagctgcacagtg	11	5	15	10	1	0	3	0	0	0	3	1	5	1	4	2	2	5	4	2	2	2	0			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:4498321A>G	uc002mao.2	+	12	1514	c.1421A>G	c.(1420-1422)AAG>AGG	p.K474R	HDGFRP2_uc002map.2_Missense_Mutation_p.K474R|HDGFRP2_uc010dtz.1_RNA|HDGFRP2_uc010dua.2_5'Flank|HDGFRP2_uc002maq.1_5'Flank	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	474					transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						GTGGAGGAGAAGCTGCAGAAG	0.647													25	19					0	0	0	0	G	4498321	G	G	4498321	3	3	215	1	0	0	0	0	1	0	0	0	7059	72	3	5	1467	5	HDGFRP2	19	4498321	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	132713	4498321	54630662	142	39697											
DOCK6	57572	broad.mit.edu	37	chr19	11323947	11323947	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccacagtgtcgtaggaGcctcaggcacaggtcggcac	8	6	14	13	2	1	0	1	0	0	0	3	1	1	1	2	4	2	4	2	4	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:11323947G>A	uc002mqs.3	-	35	4437	c.4396C>T	c.(4396-4398)CTC>TTC	p.L1466F	DOCK6_uc010xlq.1_Missense_Mutation_p.L805F	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1466					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TGTCGTAGGAGCCTCAGGCAC	0.652													12	30					0	0	0	0	A	11323947	A	A	11323947	3	1	215	1	0	0	0	0	1	0	0	0	4713	971	34	4	1803	4	DOCK6	19	11323947	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	6825626	11323947	47805036	143	39698											
ZNF440	126070	broad.mit.edu	37	chr19	11943141	11943141	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccctcattccagttcccttCgatatcatgaaaggactcac	10	12	5	14	1	3	1	3	1	0	0	7	3	6	2	3	1	0	1	3	1	2	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:11943141C>T	uc002msp.1	+	4	1306	c.1150C>T	c.(1150-1152)CGA>TGA	p.R384*		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	384	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGTTCCCTTCGATATCATGA	0.433													27	22					0	0	0	0	T	11943141	T	T	11943141	4	4	215	1	0	0	0	0	0	1	0	0	17980	876	31	1	1164	1	ZNF440	19	11943141	Nonsense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	619194	11943141	47185842	144	39699											
ZNF85	7639	broad.mit.edu	37	chr19	21132175	21132175	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attcatactggagagaaaccCtacaaatgtaaagaatgtgg	17	9	9	6	0	1	2	1	0	0	2	1	4	1	3	1	2	3	1	1	2	7	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:21132175C>A	uc002npg.3	+	4	982	c.855C>A	c.(853-855)CCC>CCA	p.P285P	ZNF85_uc010ecn.2_Silent_p.P220P|ZNF85_uc010eco.2_Silent_p.P233P|ZNF85_uc002npi.2_Silent_p.P226P	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	285						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1						GAGAGAAACCCTACAAATGTA	0.353													13	15					0.00185496	0.00194569	1	0	A	21132175	A	A	21132175	2	1	215	1	0	0	0	0	0	0	0	1	18260	668	24	4		4	ZNF85	19	21132175	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08	9189034	21132175	37996808	145	39700											
ZNF492	57615	broad.mit.edu	37	chr19	22836811	22836811	+	Frame_Shift_Del	DEL	C	-	-																															gacatgagatggtagctgaaCccccaggtaggtgagagtga																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:22836811delC	uc002nqw.3	+	3	368	c.124delC	c.(124-126)CCCfs	p.P42fs		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	42	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				GGTAGCTGAACCCCCAGGTAG	0.413													---	---	---								-	22836811	-	-	22836811	7	5	215	1	0	1	0	1	0	0	0	0	18010	507	18	0	130	0	ZNF492	19	22836811	Frame_Shift_Del	DEL	C	TCGA-CV-6962-01A-11D-1912-08	1704636	22836811	36292172	146	39701											
TMEM147	10430	broad.mit.edu	37	chr19	36037859	36037859	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcctcagctgcattcccctAtgggtcggagcccggggcat	5	10	12	14	2	1	0	1	0	0	0	4	1	3	1	4	4	3	3	4	4	1	3	rs35486099		TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:36037859A>G	uc002oaj.1	+	5	454	c.357A>G	c.(355-357)CTA>CTG	p.L119L	uc010eec.1_5'Flank|uc002oag.2_5'Flank|TMEM147_uc002oai.1_Silent_p.L70L|TMEM147_uc002oak.1_Silent_p.L74L	NM_032635	NP_116024	Q9BVK8	TM147_HUMAN	transmembrane protein 147	119	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCATTCCCCTATGGGTCGGAG	0.562													55	57					0	0	0	0	G	36037859	G	G	36037859	2	3	215	1	0	0	0	0	0	0	0	1	16127	436	16	5		5	TMEM147	19	36037859	Silent	SNP	A	TCGA-CV-6962-01A-11D-1912-08	13201048	36037859	23091124	147	39702											
RYR1	6261	broad.mit.edu	37	chr19	39013683	39013683	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccagggcgcagtggctgacGgagccgaatcccagcgcgga	8	3	16	14	5	0	1	0	1	0	0	1	4	1	3	3	4	2	2	3	4	1	0			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:39013683G>A	uc002oit.2	+	68	10405	c.10275G>A	c.(10273-10275)ACG>ACA	p.T3425T	RYR1_uc002oiu.2_Silent_p.T3425T|RYR1_uc002oiv.1_Silent_p.T345T|RYR1_uc010xuf.1_Silent_p.T345T	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3425					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGTGGCTGACGGAGCCGAATC	0.662													12	8					0	0	0	0	A	39013683	A	A	39013683	2	1	215	1	0	0	0	0	0	0	0	1	13833	1103	39	1		1	RYR1	19	39013683	Silent	SNP	G	TCGA-CV-6962-01A-11D-1912-08	2975824	39013683	20115300	148	39703											
RINL	126432	broad.mit.edu	37	chr19	39361466	39361466	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtgaatggtgagcacgtcCtcagggccttcctcttcagg	7	10	12	12	2	3	2	2	2	1	0	5	2	5	2	3	3	1	1	3	3	1	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:39361466C>T	uc002ojq.2	-	8	814	c.426G>A	c.(424-426)GAG>GAA	p.E142E	RINL_uc002ojr.1_5'Flank|RINL_uc010xuo.1_Silent_p.E256E	NM_198445	NP_940847	Q6ZS11	RINL_HUMAN	Ras and Rab interactor-like	142							GTPase activator activity			pancreas(1)	1						TGAGCACGTCCTCAGGGCCTT	0.617													29	82					0	0	0	0	T	39361466	T	T	39361466	2	4	215	1	0	0	0	0	0	0	0	1	13440	680	24	4		4	RINL	19	39361466	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08	347783	39361466	19767517	149	39704											
ADCK4	79934	broad.mit.edu	37	chr19	41206235	41206235	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggttccgcaggtcctggcTtaggccctggcactggtcca	4	10	13	14	1	0	0	0	0	0	0	3	0	3	0	4	6	0	4	4	6	1	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:41206235T>G	uc002oor.2	-	11	1317	c.1015A>C	c.(1015-1017)AGC>CGC	p.S339R	ADCK4_uc002oop.1_Missense_Mutation_p.S16R|ADCK4_uc002ooq.1_Missense_Mutation_p.S298R	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	339	Protein kinase.					integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			AGGTCCTGGCTTAGGCCCTGG	0.672													17	47					0	0	0	0	G	41206235	G	G	41206235	3	3	215	1	0	0	0	0	1	0	0	0	290	1609	56	5	639	5	ADCK4	19	41206235	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08	1844769	41206235	17922748	150	39705											
ZNF404	342908	broad.mit.edu	37	chr19	44377859	44377881	+	Frame_Shift_Del	DEL	TACAAATGCTTTTCCACATTCAT	-	-																															ctaataaaatgctggaaaacTacaaatgcttttccacattc																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:44377859_44377881delTACAAATGCTTTTCCACATTCAT	uc002oxs.3	-	2	485_507	c.476_498delATGAATGTGGAAAAGCATTTGTA	c.(475-498)AATGAATGTGGAAAAGCATTTGTAfs	p.N159fs		NM_001033719	NP_001028891	Q494X3	ZN404_HUMAN	zinc finger protein 404	162_169	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				GCTGGAAAACTACAAATGCTTTTCCACATTCATTACATTCATA	0.35													---	---	---								-	44377881	-	-	44377859	7	5	215	1	0	1	0	1	0	0	0	0	17953	1509	53	0	1155	0	ZNF404	19	44377859	Frame_Shift_Del	DEL	TACAAATGCTTTTCCACATTCAT	TCGA-CV-6962-01A-11D-1912-08	3171624	44377859	14751124	151	39706											
ZNF347	84671	broad.mit.edu	37	chr19	53644453	53644453	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggctttgccgcactcattaCacatataaggcttcactcca	11	11	6	13	1	2	0	2	0	0	0	3	0	3	0	2	2	2	3	2	2	3	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:53644453C>T	uc002qbb.1	-	5	1697	c.1628G>A	c.(1627-1629)TGT>TAT	p.C543Y	ZNF347_uc010eql.1_Missense_Mutation_p.C544Y|ZNF347_uc002qbc.1_Missense_Mutation_p.C544Y	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	543	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		GCACTCATTACACATATAAGG	0.398													60	51					0	0	0	0	T	53644453	T	T	53644453	3	4	215	1	0	0	0	0	1	0	0	0	17928	478	17	4	895	4	ZNF347	19	53644453	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	9266594	53644453	5484530	152	39707											
LILRB3	11025	broad.mit.edu	37	chr19	54746172	54746173	+	Frame_Shift_Ins	INS	-	T	T																															ggctcagcccagagggtgggINStttggggaagggccctagat																										TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:54746172_54746173insT	uc010erh.1	-	3	208_209	c.84_85insA	c.(82-87)AAACCCfs	p.K28fs	LILRA6_uc002qew.1_Frame_Shift_Ins_p.K28fs|LILRB3_uc002qeh.1_Frame_Shift_Ins_p.K28fs|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Frame_Shift_Ins_p.K28fs|LILRA6_uc002qek.1_Frame_Shift_Ins_p.K28fs|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Frame_Shift_Ins_p.K28fs|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Frame_Shift_Ins_p.K28fs|LILRB3_uc002qep.1_Frame_Shift_Ins_p.K28fs|LILRB3_uc002qeq.1_Frame_Shift_Ins_p.K28fs|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Frame_Shift_Ins_p.K28fs|LILRA6_uc010yep.1_Frame_Shift_Ins_p.K28fs|LILRA6_uc010yeq.1_Frame_Shift_Ins_p.K28fs|LILRA6_uc002qet.3_RNA|LILRA6_uc002qeu.1_Frame_Shift_Ins_p.K28fs|LILRA6_uc002qev.1_5'Flank	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	28_29	Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGAGGGTGGGTTTGGGGAAGG	0.619													---	---	---								T	54746173	T	T	54746172	7	5	215	1	0	1	1	0	0	0	0	0	8833	1261	44	0		0	LILRB3	19	54746172	Frame_Shift_Ins	INS	-	TCGA-CV-6962-01A-11D-1912-08	1101719	54746172	4382811	153	39708											
UBE2M	9040	broad.mit.edu	37	chr19	59068277	59068277	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accttaaaactgaacacaaaCttcccactcttgtagaagcc	15	9	4	13	0	1	2	0	1	1	1	2	2	2	2	3	0	4	1	3	0	6	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr19:59068277C>T	uc002qtl.3	-	3	820	c.225G>A	c.(223-225)AAG>AAA	p.K75K	CHMP2A_uc002qti.2_5'Flank|CHMP2A_uc002qtj.2_5'Flank|CHMP2A_uc002qtk.2_5'Flank|LOC100131691_uc002qtm.2_5'Flank	NM_003969	NP_003960	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M	75					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity			ovary(1)|pancreas(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TGAACACAAACTTCCCACTCT	0.567													25	10					0	0	0	0	T	59068277	T	T	59068277	2	4	215	1	0	0	0	0	0	0	0	1	16933	564	20	4		4	UBE2M	19	59068277	Silent	SNP	C	TCGA-CV-6962-01A-11D-1912-08	4322105	59068277	60706	154	39709											
C20orf26	26074	broad.mit.edu	37	chr20	20177278	20177278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacttcagtcaccaccagcGcgaagaacacgggcacatgc	12	5	9	15	3	2	1	2	0	0	1	2	2	2	1	2	1	4	1	2	1	3	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr20:20177278G>A	uc002wru.2	+	16	1731	c.1655G>A	c.(1654-1656)CGC>CAC	p.R552H	C20orf26_uc010zse.1_Missense_Mutation_p.R532H	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	552										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CACCACCAGCGCGAAGAACAC	0.463													42	80					0	0	0	0	A	20177278	A	A	20177278	3	1	215	1	0	0	0	0	1	0	0	0	2116	1087	38	1	1745	1	C20orf26	20	20177278	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08		20177278	42848242	155	39710											
C20orf71	128861	broad.mit.edu	37	chr20	31813043	31813043	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcagtgtccatgtggccAtcctcactgagtaagacccc	9	8	9	15	0	1	2	1	1	0	1	3	2	3	2	6	1	1	2	6	1	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	e7311353-3925-4bc6-96a7-86ad927a0ed1	g.chr20:31813043A>C	uc002wyr.2	+	4	734	c.526A>C	c.(526-528)ATC>CTC	p.I176L	C20orf71_uc002wys.2_Missense_Mutation_p.I140L	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium	176						extracellular region	lipid binding			ovary(1)|skin(1)	2						CCATGTGGCCATCCTCACTGA	0.577													4	141					0	0	0	0	C	31813043	C	C	31813043	3	2	215	1	0	0	0	0	1	0	0	0	2127	217	8	5	540	5	C20orf71	20	31813043	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	11635765	31813043	31212477	156	39711											
NEURL2	140825	broad.mit.edu	37	chr20	44519288	44519288	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggttgtggtggcgcgtgaTggcgaagacccaggtgtggc	5	8	20	8	4	0	2	0	1	0	1	0	3	0	2	1	6	0	1	1	6	1	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr20:44519288T>C	uc002xqg.1	-	1	614	c.343A>G	c.(343-345)ATC>GTC	p.I115V	CTSA_uc002xqh.2_5'Flank|CTSA_uc002xqj.3_5'Flank|CTSA_uc002xqi.2_5'Flank|CTSA_uc010zxi.1_5'Flank|CTSA_uc002xqk.3_5'Flank	NM_080749	NP_542787	Q9BR09	NEUL2_HUMAN	neuralized-like protein 2	115	NHR.				intracellular signal transduction						0		Myeloproliferative disorder(115;0.0122)				TGGCGCGTGATGGCGAAGACC	0.706													46	9					0	0	0	0	C	44519288	C	C	44519288	3	2	215	1	0	0	0	0	1	0	0	0	10400	1464	51	5	522	5	NEURL2	20	44519288	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08	12706245	44519288	18506232	157	39712											
APCDD1L	164284	broad.mit.edu	37	chr20	57045686	57045686	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtggagatccaaggtccaTtaaggcgtggaggcaggatc	10	8	15	8	1	0	1	0	0	0	1	3	4	2	3	2	6	0	1	2	6	2	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr20:57045686T>G	uc002xze.1	-	2	353	c.167A>C	c.(166-168)AAT>ACT	p.N56T	APCDD1L_uc010zzp.1_Missense_Mutation_p.N67T	NM_153360	NP_699191	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated	56						integral to membrane				ovary(1)	1	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			CCAAGGTCCATTAAGGCGTGG	0.617													7	10					0	0	0	0	G	57045686	G	G	57045686	3	3	215	1	0	0	0	0	1	0	0	0	766	1493	52	5	1350	5	APCDD1L	20	57045686	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08	12526398	57045686	5979834	158	39713											
TPTE	7179	broad.mit.edu	37	chr21	10942773	10942773	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcgccttttgttttctgaaAcctgacagtttaaaatcgtc	10	16	6	9	2	1	2	0	2	1	0	4	2	1	2	2	0	1	2	2	0	3	6			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr21:10942773A>G	uc002yip.1	-	13	1036	c.668T>C	c.(667-669)GTT>GCT	p.V223A	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.V205A|TPTE_uc002yir.1_Missense_Mutation_p.V185A|TPTE_uc010gkv.1_Missense_Mutation_p.V85A	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	223					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTTTTCTGAAACCTGACAGTT	0.348													51	289					0	0	0	0	G	10942773	G	G	10942773	3	3	215	1	0	0	0	0	1	0	0	0	16497	57	2	5	1035	5	TPTE	21	10942773	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08		10942773	37187122	159	39714											
BAGE2	85319	broad.mit.edu	37	chr21	11098870	11098870	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccagcctccaactccccCttctcctggtcctctaagcc	5	10	5	21	0	2	0	0	0	2	0	7	0	6	0	8	1	3	1	8	1	2	2			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr21:11098870C>A	uc002yit.1	-	1	56	c.-152G>T	c.(-154--150)AAGGG>AATGG		BAGE_uc002yix.2_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccaactcccccttctcctggt	0													11	14					5.50884e-06	5.97306e-06	1	0	A	11098870	A	A	11098870	1	1	215	1	0	0	0	0	0	0	0	0	1294	696	24	4		4	BAGE2	21	11098870	Translation_Start_Site	SNP	C	TCGA-CV-6962-01A-11D-1912-08	156097	11098870	37031025	160	39715											
NCAM2	4685	broad.mit.edu	37	chr21	22881352	22881352	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtggcaaaagtaaagaacTcgaagaaggaaaagctgcat	19	5	11	6	1	0	2	0	0	0	2	1	4	0	3	0	2	3	4	0	2	9	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr21:22881352T>A	uc002yld.1	+	16	2507	c.2258T>A	c.(2257-2259)CTC>CAC	p.L753H	NCAM2_uc011acb.1_Missense_Mutation_p.L611H	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	753	Cytoplasmic (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		AGTAAAGAACTCGAAGAAGGA	0.463													30	31					0	0	0	0	A	22881352	A	A	22881352	3	1	215	1	0	0	0	0	1	0	0	0	10257	1551	54	5	2320	5	NCAM2	21	22881352	Missense_Mutation	SNP	T	TCGA-CV-6962-01A-11D-1912-08	11782482	22881352	25248543	161	39716											
USP16	10600	broad.mit.edu	37	chr21	30419482	30419482	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagatccagaaactgctttCtgtactcttgcaaacaggga	13	10	9	9	0	2	2	0	0	2	2	3	4	3	3	1	1	5	3	1	1	4	3			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr21:30419482C>A	uc002ymy.2	+	14	2053	c.1851C>A	c.(1849-1851)TTC>TTA	p.F617L	USP16_uc002ymx.2_Missense_Mutation_p.F616L|USP16_uc002ymw.2_Missense_Mutation_p.F617L|USP16_uc011acm.1_Missense_Mutation_p.F602L|USP16_uc011acn.1_Missense_Mutation_p.F283L|USP16_uc011aco.1_Missense_Mutation_p.F307L	NM_006447	NP_006438	Q9Y5T5	UBP16_HUMAN	ubiquitin specific protease 16 isoform a	617					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4						AAACTGCTTTCTGTACTCTTG	0.363													62	13					9.4991e-31	1.22222e-30	1	0	A	30419482	A	A	30419482	3	1	215	1	0	0	0	0	1	0	0	0	17115	912	32	2	1901	2	USP16	21	30419482	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	7538130	30419482	17710413	162	39717											
TNRC6B	23112	broad.mit.edu	37	chr22	40658079	40658079	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtcctgcatgctccttggggGtggggcagggcctcctccct	2	10	15	14	0	0	0	0	0	0	0	4	0	4	0	5	5	2	3	5	5	0	1			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chr22:40658079G>T	uc011aor.1	+	4	570	c.359G>T	c.(358-360)GGT>GTT	p.G120V	TNRC6B_uc003aym.2_Missense_Mutation_p.G156V|TNRC6B_uc003ayn.3_Missense_Mutation_p.G120V|TNRC6B_uc003ayo.2_5'Flank	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	120					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						CTCCTTGGGGGTGGGGCAGGG	0.632													8	1					0.00448238	0.00467621	1	0	T	40658079	T	T	40658079	3	4	215	1	0	0	0	0	1	0	0	0	16407	1261	44	4	494	4	TNRC6B	22	40658079	Missense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08		40658079	10646487	163	39718											
CXorf22	170063	broad.mit.edu	37	chrX	35966561	35966561	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagccaagaattgtagatgaAgaggcaatgtgagtatatac	16	9	11	5	0	0	5	0	2	0	3	0	5	0	5	1	1	2	3	1	1	8	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chrX:35966561A>G	uc004ddj.2	+	4	707	c.648A>G	c.(646-648)GAA>GAG	p.E216E	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	216										large_intestine(1)|lung(1)|ovary(1)	3						TTGTAGATGAAGAGGCAATGT	0.373													37	9					0	0	0	0	G	35966561	G	G	35966561	2	3	215	1	0	0	0	0	0	0	0	1	4119	69	3	5		5	CXorf22	23	35966561	Silent	SNP	A	TCGA-CV-6962-01A-11D-1912-08		35966561	119303999	164	39719											
ZNF157	7712	broad.mit.edu	37	chrX	47271931	47271931	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaggctttgttagacgtaaAagaacacccagaggagataa	17	7	10	7	1	0	4	0	0	0	4	0	5	0	4	1	2	1	3	1	2	5	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chrX:47271931A>C	uc004dhr.1	+	4	528	c.459A>C	c.(457-459)AAA>AAC	p.K153N		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	153					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTAGACGTAAAAGAACACCCA	0.383													21	5					0	0	0	0	C	47271931	C	C	47271931	3	2	215	1	0	0	0	0	1	0	0	0	17804	11	1	5	473	5	ZNF157	23	47271931	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	11305370	47271931	107998629	165	39720											
FOXR2	139628	broad.mit.edu	37	chrX	55650824	55650824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttcacccgacagcatttccCctttttctggacagctccgg	6	13	7	15	2	2	0	1	0	1	0	4	2	4	1	4	2	2	2	4	2	0	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chrX:55650824C>T	uc004duo.2	+	1	992	c.680C>T	c.(679-681)CCC>CTC	p.P227L		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	227	Fork-head.				embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						CAGCATTTCCCCTTTTTCTGG	0.498													52	7					0	0	0	0	T	55650824	T	T	55650824	3	4	215	1	0	0	0	0	1	0	0	0	6066	623	22	4	682	4	FOXR2	23	55650824	Missense_Mutation	SNP	C	TCGA-CV-6962-01A-11D-1912-08	8378893	55650824	99619736	166	39721											
ARMCX5	64860	broad.mit.edu	37	chrX	101857639	101857639	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcctggttctggcctgaagaAgagacctctcttcaagttta	9	13	9	10	0	3	3	1	1	2	2	5	4	4	3	3	2	0	2	3	2	4	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chrX:101857639A>T	uc004ejg.2	+	6	1451	c.570A>T	c.(568-570)GAA>GAT	p.E190D	ARMCX5_uc004ejh.2_Missense_Mutation_p.E190D	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	190							binding			ovary(1)	1						GGCCTGAAGAAGAGACCTCTC	0.448													74	12					0	0	0	0	T	101857639	T	T	101857639	3	4	215	1	0	0	0	0	1	0	0	0	964	69	3	5	572	5	ARMCX5	23	101857639	Missense_Mutation	SNP	A	TCGA-CV-6962-01A-11D-1912-08	46206815	101857639	53412921	167	39722											
FAM70A	55026	broad.mit.edu	37	chrX	119421060	119421060	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acataatggcaccggttagcGtagagtggtttcagatcctg	10	11	12	8	2	1	2	1	0	0	2	2	2	2	2	2	3	1	4	2	3	3	4			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chrX:119421060G>T	uc004eso.3	-	5	599	c.372C>A	c.(370-372)TAC>TAA	p.Y124*	FAM70A_uc004esp.3_Nonsense_Mutation_p.Y124*|FAM70A_uc010nqo.2_Nonsense_Mutation_p.Y124*	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	124						integral to membrane				lung(1)|breast(1)	2						ACCGGTTAGCGTAGAGTGGTT	0.448													6	173					2.7689e-08	3.089e-08	1	0	T	119421060	T	T	119421060	4	4	215	1	0	0	0	0	0	1	0	0	5637	1140	40	3	701	3	FAM70A	23	119421060	Nonsense_Mutation	SNP	G	TCGA-CV-6962-01A-11D-1912-08	17563421	119421060	35849500	168	39723											
SPANXE	171489	broad.mit.edu	37	chrX	140785697	140785697	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggggttgattctgttcttTcgggcgtggtcattcaccag	5	14	14	8	2	4	1	2	1	2	0	5	1	4	1	1	4	0	2	1	4	0	5			TCGA-CV-6962-01A-11D-1912-08	TCGA-CV-6962-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b2767d9-10b4-4ec4-9437-5a5186e284ca	dc7fbfbb-e6ec-4ded-b1de-80e5c65f8cb1	g.chrX:140785697T>C	uc004fbq.2	-	2	312	c.219A>G	c.(217-219)CGA>CGG	p.R73R		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	SPANX family, member E	73						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					TTCTGTTCTTTCGGGCGTGGT	0.433													178	49					0	0	0	0	C	140785697	C	C	140785697	2	2	215	1	0	0	0	0	0	0	0	1	15055	1770	62	5		5	SPANXE	23	140785697	Silent	SNP	T	TCGA-CV-6962-01A-11D-1912-08	21364637	140785697	14484863	169	39724											
KIAA1751	85452	broad.mit.edu	37	chr1	1896456	1896456	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaggatgtccttgtccatCtttgtcccgcccacgggctt	4	13	9	15	2	1	0	0	0	1	0	5	1	5	1	5	2	0	1	5	2	0	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:1896456C>G	uc001aim.1	-	13	1602	c.1446G>C	c.(1444-1446)AAG>AAC	p.K482N	KIAA1751_uc009vkz.1_Missense_Mutation_p.K482N	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	482										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CCTTGTCCATCTTTGTCCCGC	0.672													3	20					0	0	0	0	G	1896456	G	G	1896456	3	3	216	1	0	0	0	0	1	0	0	0	8295	912	32	2	866	2	KIAA1751	1	1896456	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08		1896456	247354165	1	39725											
C1orf127	148345	broad.mit.edu	37	chr1	11017770	11017770	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaggctggcgtcttcaagaGaagccaccagctcccctcga	9	7	10	15	2	3	1	2	0	1	1	5	3	4	1	4	2	2	2	4	2	2	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:11017770G>A	uc010oao.1	-	3	154	c.149C>T	c.(148-150)TCT>TTT	p.S50F	C1orf127_uc001arr.1_Missense_Mutation_p.S50F|C1orf127_uc001ars.1_Missense_Mutation_p.S50F	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	50										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GTCTTCAAGAGAAGCCACCAG	0.577													13	106					0	0	0	0	A	11017770	A	A	11017770	3	1	216	1	0	0	0	0	1	0	0	0	2003	942	33	2	1899	2	C1orf127	1	11017770	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	9121314	11017770	238232851	2	39726											
PRAMEF11	440560	broad.mit.edu	37	chr1	12887265	12887265	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacatccatgtgggagagaaCgagcttctgaagattcctca	12	9	11	9	1	2	3	1	1	1	2	4	7	4	4	2	1	2	1	2	1	2	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:12887265C>T	uc001auk.2	-	3	788	c.592G>A	c.(592-594)GTT>ATT	p.V198I		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	198	LRR 1.										0						TGGGAGAGAACGAGCTTCTGA	0.517													12	458					0	0	0	0	T	12887265	T	T	12887265	3	4	216	1	0	0	0	0	1	0	0	0	12487	536	19	1	726	1	PRAMEF11	1	12887265	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	1869495	12887265	236363356	3	39727											
AKR7A2	8574	broad.mit.edu	37	chr1	19632584	19632584	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggcgctggcgccatatgcGgcctgcagggccttctccac	4	7	15	15	3	1	0	0	0	1	0	2	0	1	0	4	5	2	2	4	5	1	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:19632584G>A	uc001bbw.2	-	6	868	c.846C>T	c.(844-846)GCC>GCT	p.A282A	AKR7A2_uc001bbx.2_Silent_p.A247A	NM_003689	NP_003680	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2	282					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CGCCATATGCGGCCTGCAGGG	0.632													10	66					0	0	0	0	A	19632584	A	A	19632584	2	1	216	1	0	0	0	0	0	0	0	1	475	1103	39	1		1	AKR7A2	1	19632584	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	6745319	19632584	229618037	4	39728											
NBPF3	84224	broad.mit.edu	37	chr1	21800026	21800026	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccaagtcgactcaactctCattgactcatcctctcatga	11	11	5	14	1	4	2	4	2	2	0	8	4	5	2	2	0	1	0	2	0	2	1	rs138236134		TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:21800026C>T	uc001ber.2	+	7	1238	c.888C>T	c.(886-888)CTC>CTT	p.L296L	NBPF3_uc001bes.2_Silent_p.L240L|NBPF3_uc009vqb.2_Silent_p.L296L|NBPF3_uc010odm.1_Silent_p.L226L	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	296	NBPF 1.					cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ACTCAACTCTCATTGACTCAT	0.463													31	222					0	0	0	0	T	21800026	T	T	21800026	2	4	216	1	0	0	0	0	0	0	0	1	10251	813	29	2		2	NBPF3	1	21800026	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	2167442	21800026	227450595	5	39729											
GPR3	2827	broad.mit.edu	37	chr1	27721255	27721255	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgctgctgctgttcctcttCcaagatccccttccgatccc	4	13	6	18	1	1	1	0	0	1	1	6	2	6	1	6	0	3	4	6	0	1	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:27721255C>T	uc001bod.2	+	2	1048	c.953C>T	c.(952-954)TCC>TTC	p.S318F		NM_005281	NP_005272	P46089	GPR3_HUMAN	G protein-coupled receptor 3	318	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane				ovary(1)	1		Breast(348;1.53e-05)|Ovarian(437;0.0606)|all_lung(284;0.157)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.81e-26)|Colorectal(126;1.24e-08)|KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;4.45e-06)|Lung(427;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|LUSC - Lung squamous cell carcinoma(448;0.008)|READ - Rectum adenocarcinoma(331;0.0419)		TGTTCCTCTTCCAAGATCCCC	0.527													26	156					0	0	0	0	T	27721255	T	T	27721255	3	4	216	1	0	0	0	0	1	0	0	0	6724	855	30	2	955	2	GPR3	1	27721255	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	5921229	27721255	221529366	6	39730											
HIVEP3	59269	broad.mit.edu	37	chr1	42045932	42045932	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcagggtgagggaggggagGaatttcctttgtgtcagatg	8	11	18	4	0	1	2	1	1	0	1	2	5	2	5	1	5	1	1	1	5	1	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:42045932G>A	uc001cgz.3	-	4	5750	c.4537C>T	c.(4537-4539)CCT>TCT	p.P1513S	HIVEP3_uc001cha.3_Missense_Mutation_p.P1513S|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1513					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGGAGGGGAGGAATTTCCTTT	0.557													6	57					0	0	0	0	A	42045932	A	A	42045932	3	1	216	1	0	0	0	0	1	0	0	0	7227	1174	41	2	2707	2	HIVEP3	1	42045932	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	14324677	42045932	207204689	7	39731											
IPO13	9670	broad.mit.edu	37	chr1	44424510	44424510	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcagtcatcatgaggatgaTcatgaaggccctgagcttcg	11	10	11	9	1	4	4	4	4	0	0	5	5	4	5	1	2	1	1	1	2	1	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:44424510T>C	uc001ckx.2	+	11	2772	c.1977T>C	c.(1975-1977)GAT>GAC	p.D659D		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	659	HEAT 11.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				ATGAGGATGATCATGAAGGCC	0.562													11	78					0	0	0	0	C	44424510	C	C	44424510	2	2	216	1	0	0	0	0	0	0	0	1	7833	1432	50	5		5	IPO13	1	44424510	Silent	SNP	T	TCGA-CV-7089-01A-11D-2012-08	2378578	44424510	204826111	8	39732											
ZNF644	84146	broad.mit.edu	37	chr1	91404992	91404992	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtttagttaatgttttaGtgctatcactatctacaggt	9	19	8	5	0	2	0	1	0	1	0	2	0	2	0	0	1	2	5	0	1	6	9			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:91404992G>C	uc001dnw.2	-	3	2061	c.1919C>G	c.(1918-1920)ACT>AGT	p.T640S	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.T640S	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	640					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TAATGTTTTAGTGCTATCACT	0.348													3	112					0	0	0	0	C	91404992	C	C	91404992	3	2	216	1	0	0	0	0	1	0	0	0	18127	1029	36	4	2080	4	ZNF644	1	91404992	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	46980482	91404992	157845629	9	39733											
COL11A1	1301	broad.mit.edu	37	chr1	103455092	103455092	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actctgtcaccttttagaccCatgtcacctttgaatcctgg	8	14	6	13	0	3	2	2	1	1	1	4	2	4	2	4	1	0	0	4	1	2	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:103455092C>G	uc001dul.2	-	29	2694	c.2376G>C	c.(2374-2376)ATG>ATC	p.M792I	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.M804I|COL11A1_uc001dun.2_Missense_Mutation_p.M753I|COL11A1_uc009weh.2_Missense_Mutation_p.M676I	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	792	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTTTTAGACCCATGTCACCTT	0.289													4	55					0	0	0	0	G	103455092	G	G	103455092	3	3	216	1	0	0	0	0	1	0	0	0	3682	594	21	4	3200	4	COL11A1	1	103455092	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	12050100	103455092	145795529	10	39734											
PSRC1	84722	broad.mit.edu	37	chr1	109824269	109824269	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttggagggcctctttccaGatgtagcccggagagccctg	6	10	14	11	1	1	2	0	0	1	2	2	4	2	3	4	3	2	2	4	3	1	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:109824269G>C	uc001dxg.2	-	4	613	c.491C>G	c.(490-492)TCT>TGT	p.S164C	PSRC1_uc001dxb.2_Translation_Start_Site|PSRC1_uc001dxc.2_Missense_Mutation_p.S164C|PSRC1_uc001dxd.2_Missense_Mutation_p.S164C|PSRC1_uc001dxe.2_Missense_Mutation_p.S164C|PSRC1_uc001dxf.2_Missense_Mutation_p.S164C|PSRC1_uc001dxh.2_Missense_Mutation_p.S164C|PSRC1_uc001dxi.2_Missense_Mutation_p.S164C|PSRC1_uc001dxj.2_Missense_Mutation_p.S164C	NM_001032290	NP_001027461	Q6PGN9	PSRC1_HUMAN	proline/serine-rich coiled-coil 1 isoform c	164	4 X 4 AA repeats of P-X-X-P.				cell division|microtubule bundle formation|mitotic metaphase plate congression|negative regulation of cell growth|positive regulation of microtubule polymerization|positive regulation of transcription, DNA-dependent|regulation of mitotic spindle organization	cytosol|midbody|spindle pole	microtubule binding				0		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0286)|Lung(183;0.0658)|COAD - Colon adenocarcinoma(174;0.112)|Epithelial(280;0.188)|all cancers(265;0.213)		CCTCTTTCCAGATGTAGCCCG	0.562													18	84					0	0	0	0	C	109824269	C	C	109824269	3	2	216	1	0	0	0	0	1	0	0	0	12781	942	33	2	591	2	PSRC1	1	109824269	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	6369177	109824269	139426352	11	39735											
MOV10	4343	broad.mit.edu	37	chr1	113238852	113238852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggaataccgggtcttaattaCcaccctcatcactgccggca	10	9	8	14	2	3	0	2	0	1	0	3	1	3	1	4	3	3	1	4	3	4	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:113238852C>T	uc001eck.2	+	12	2132	c.1862C>T	c.(1861-1863)ACC>ATC	p.T621I	MOV10_uc001ecl.2_Intron|MOV10_uc001ecn.2_Missense_Mutation_p.T621I|MOV10_uc001ecm.2_Missense_Mutation_p.T561I|MOV10_uc009wgj.1_Missense_Mutation_p.T561I	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	621					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		GTCTTAATTACCACCCTCATC	0.532													5	52					0	0	0	0	T	113238852	T	T	113238852	3	4	216	1	0	0	0	0	1	0	0	0	9771	507	18	4	1904	4	MOV10	1	113238852	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	3414583	113238852	136011769	12	39736											
NBPF9	400818	broad.mit.edu	37	chr1	144816648	144816648	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggctcatcctctcatgttGaacgggaagatgctgtacac	9	12	10	10	1	2	2	2	1	1	1	4	3	3	3	1	2	3	4	1	2	3	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:144816648G>C	uc009wig.1	+	13	1631	c.1555G>C	c.(1555-1557)GAA>CAA	p.E519Q	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.E519Q|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF9_uc009wii.1_Missense_Mutation_p.E248Q|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Missense_Mutation_p.E179Q	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	519	NBPF 2.					cytoplasm					0						CTCTCATGTTGAACGGGAAGA	0.458													39	275					0	0	0	0	C	144816648	C	C	144816648	3	2	216	1	0	0	0	0	1	0	0	0	10253	1291	45	2	1591	2	NBPF9	1	144816648	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	31577796	144816648	104433973	13	39737											
CTSS	1520	broad.mit.edu	37	chr1	150722557	150722557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctttattggccacagcttCtttcaggacatcttctctgc	6	15	7	13	0	4	0	1	0	3	0	5	1	4	1	2	2	2	1	2	2	1	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:150722557C>T	uc001evn.2	-	6	851	c.718G>A	c.(718-720)GAA>AAA	p.E240K	CTSS_uc010pcj.1_Missense_Mutation_p.E190K|CTSS_uc001evo.1_Missense_Mutation_p.E240K	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	240					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			GCCACAGCTTCTTTCAGGACA	0.393													8	29					0	0	0	0	T	150722557	T	T	150722557	3	4	216	1	0	0	0	0	1	0	0	0	4058	922	32	2	289	2	CTSS	1	150722557	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	5905909	150722557	98528064	14	39738											
FLAD1	80308	broad.mit.edu	37	chr1	154956218	154956218	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttccagaggcaggaacaaagGagtcgcttgtcaaggatctg	12	8	13	8	1	2	1	1	0	1	1	4	4	3	4	1	4	1	2	1	4	3	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:154956218G>C	uc001fgf.1	+	1	402	c.48G>C	c.(46-48)AGG>AGC	p.R16S	FLAD1_uc001fgc.2_Intron|FLAD1_uc001fgd.1_Missense_Mutation_p.R16S|FLAD1_uc001fge.1_Intron|FLAD1_uc001fgg.1_Intron	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	16					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AGGAACAAAGGAGTCGCTTGT	0.478													4	75					0	0	0	0	C	154956218	C	C	154956218	3	2	216	1	0	0	0	0	1	0	0	0	5952	1165	41	2	50	2	FLAD1	1	154956218	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	4233661	154956218	94294403	15	39739											
RUSC1	23623	broad.mit.edu	37	chr1	155296505	155296505	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccacctggacctgctctttGagcaccaccaccacctgccc	7	8	6	20	0	1	1	0	1	1	0	2	2	2	2	8	1	3	2	8	1	0	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:155296505G>C	uc001fkj.2	+	8	2225	c.1996G>C	c.(1996-1998)GAG>CAG	p.E666Q	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fki.2_5'Flank|RUSC1_uc001fkk.2_Intron|RUSC1_uc009wqn.1_Intron|RUSC1_uc009wqo.1_Missense_Mutation_p.E197Q|RUSC1_uc001fkl.2_Missense_Mutation_p.E256Q|RUSC1_uc001fkp.2_Missense_Mutation_p.E197Q|RUSC1_uc001fkq.2_Intron|RUSC1_uc010pgb.1_Missense_Mutation_p.E164Q|RUSC1_uc009wqp.1_Missense_Mutation_p.E191Q|RUSC1_uc001fkn.2_5'UTR|RUSC1_uc001fko.2_Intron|RUSC1_uc001fkr.2_Missense_Mutation_p.E197Q|RUSC1_uc001fks.2_5'UTR	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	666	RUN.					cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			CCTGCTCTTTGAGCACCACCA	0.642													22	89					0	0	0	0	C	155296505	C	C	155296505	3	2	216	1	0	0	0	0	1	0	0	0	13815	1291	45	2	2153	2	RUSC1	1	155296505	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	340287	155296505	93954116	16	39740											
FCRL4	83417	broad.mit.edu	37	chr1	157556033	157556033	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtacagtagtatccccctgCatggctctgtctgatggcag	7	12	11	11	0	2	1	0	1	2	0	3	1	3	1	2	2	2	6	2	2	3	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:157556033C>A	uc001fqw.2	-	6	1196	c.1060G>T	c.(1060-1062)GCA>TCA	p.A354S	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	354	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				TATCCCCCTGCATGGCTCTGT	0.537													5	106					3.59834e-05	6.9791e-05	1	0	A	157556033	A	A	157556033	3	1	216	1	0	0	0	0	1	0	0	0	5829	710	25	4	515	4	FCRL4	1	157556033	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	2259528	157556033	91694588	17	39741											
MNDA	4332	broad.mit.edu	37	chr1	158817562	158817562	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttatgaaatacaggataaTacaggatccatggatgtagt	16	12	9	4	0	0	1	0	1	0	0	1	4	1	4	1	3	2	1	1	3	6	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:158817562T>C	uc001fsz.1	+	6	1232	c.1032T>C	c.(1030-1032)AAT>AAC	p.N344N		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	344	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TACAGGATAATACAGGATCCA	0.378													12	73					0	0	0	0	C	158817562	C	C	158817562	2	2	216	1	0	0	0	0	0	0	0	1	9729	1403	49	5		5	MNDA	1	158817562	Silent	SNP	T	TCGA-CV-7089-01A-11D-2012-08	1261529	158817562	90433059	18	39742											
ABL2	27	broad.mit.edu	37	chr1	179077353	179077353	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttcctccttcctgtgtttCtgatgtggactgtcctgcag	3	17	9	12	0	1	1	0	1	1	0	5	2	5	2	4	1	1	2	4	1	0	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:179077353C>G	uc001gmj.3	-	12	3336	c.3049G>C	c.(3049-3051)GAA>CAA	p.E1017Q	ABL2_uc010pnf.1_Missense_Mutation_p.E914Q|ABL2_uc010png.1_Missense_Mutation_p.E893Q|ABL2_uc010pnh.1_Missense_Mutation_p.E996Q|ABL2_uc001gmg.3_Missense_Mutation_p.E899Q|ABL2_uc001gmi.3_Missense_Mutation_p.E1002Q|ABL2_uc001gmh.3_Missense_Mutation_p.E981Q|ABL2_uc010pne.1_Missense_Mutation_p.E878Q	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	1017	Pro-rich.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TCCTGTGTTTCTGATGTGGAC	0.587			T	ETV6	AML								19	119					0	0	0	0	G	179077353	G	G	179077353	3	3	216	1	0	0	0	0	1	0	0	0	93	922	32	2	503	2	ABL2	1	179077353	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	20259791	179077353	70173268	19	39743											
ZNF281	23528	broad.mit.edu	37	chr1	200376835	200376835	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggaggtatttggagtattCttgcaacatacttgctttat	9	18	9	5	0	1	0	0	0	1	0	1	2	1	2	0	3	4	4	0	3	5	10			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:200376835C>G	uc001gve.2	-	2	2106	c.1999G>C	c.(1999-2001)GAA>CAA	p.E667Q	ZNF281_uc001gvf.1_Missense_Mutation_p.E667Q|ZNF281_uc001gvg.1_Missense_Mutation_p.E631Q	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	667					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						TTGGAGTATTCTTGCAACATA	0.403													8	91					0	0	0	0	G	200376835	G	G	200376835	3	3	216	1	0	0	0	0	1	0	0	0	17885	922	32	2	692	2	ZNF281	1	200376835	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	21299482	200376835	48873786	20	39744											
ZNF281	23528	broad.mit.edu	37	chr1	200377024	200377024	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatactttgtaaaacctcatCaggaattccagacttgtcat	14	13	5	9	0	3	1	3	0	0	1	4	2	4	2	2	1	2	1	2	1	5	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:200377024C>A	uc001gve.2	-	2	1917	c.1810G>T	c.(1810-1812)GAT>TAT	p.D604Y	ZNF281_uc001gvf.1_Missense_Mutation_p.D604Y|ZNF281_uc001gvg.1_Missense_Mutation_p.D568Y	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	604					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						AAAACCTCATCAGGAATTCCA	0.388													7	52					2.7689e-08	5.5511e-08	1	0	A	200377024	A	A	200377024	3	1	216	1	0	0	0	0	1	0	0	0	17885	826	29	2	881	2	ZNF281	1	200377024	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	189	200377024	48873597	21	39745											
PPP1R15B	84919	broad.mit.edu	37	chr1	204378784	204378784	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatggggtctttgagtcacGacagcctttctcattttccc	7	14	9	11	1	3	2	2	1	2	1	5	3	4	2	2	2	1	0	2	2	0	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:204378784G>A	uc001hav.3	-	1	2161	c.1756C>T	c.(1756-1758)CGT>TGT	p.R586C		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	586					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			TTTGAGTCACGACAGCCTTTC	0.438													4	54					0	0	0	0	A	204378784	A	A	204378784	3	1	216	1	0	0	0	0	1	0	0	0	12424	1058	37	1	393	1	PPP1R15B	1	204378784	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	4001760	204378784	44871837	22	39746											
USH2A	7399	broad.mit.edu	37	chr1	215823958	215823958	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtctcagccccatgggcgctGctggagaacagcctgtagag	8	7	14	12	1	1	2	1	0	1	2	2	3	1	2	3	2	4	3	3	2	2	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:215823958G>A	uc001hku.1	-	65	14706	c.14319C>T	c.(14317-14319)AGC>AGT	p.S4773S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4773	Fibronectin type-III 33.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CATGGGCGCTGCTGGAGAACA	0.493										HNSCC(13;0.011)			15	88					0	0	0	0	A	215823958	A	A	215823958	2	1	216	1	0	0	0	0	0	0	0	1	17104	1310	46	4		4	USH2A	1	215823958	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	11445174	215823958	33426663	23	39747											
TP53BP2	7159	broad.mit.edu	37	chr1	223987709	223987709	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacattgagaacggacgcacTttcttctctttctccctcag	9	13	6	13	2	4	1	1	1	3	1	6	3	4	2	1	1	2	1	1	1	2	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr1:223987709T>A	uc010pvb.1	-	11	1669	c.1377A>T	c.(1375-1377)AAA>AAT	p.K459N	TP53BP2_uc001hod.2_Missense_Mutation_p.K330N|TP53BP2_uc010puz.1_Translation_Start_Site|TP53BP2_uc010pva.1_Missense_Mutation_p.K98N	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	453					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		ACGGACGCACTTTCTTCTCTT	0.428													5	51					0	0	0	0	A	223987709	A	A	223987709	3	1	216	1	0	0	0	0	1	0	0	0	16451	1606	56	5	2059	5	TP53BP2	1	223987709	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	8163751	223987709	25262912	24	39748											
ALMS1	7840	broad.mit.edu	37	chr2	73828456	73828456	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctggagggagccactgcggGagcagaactgtcaggggcag	9	4	18	10	1	1	1	1	0	0	1	1	4	1	4	2	5	4	2	2	5	1	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr2:73828456G>A	uc002sje.1	+	21	12121	c.12010G>A	c.(12010-12012)GAG>AAG	p.E4004K	ALMS1_uc002sjf.1_Missense_Mutation_p.E3960K|ALMS1_uc002sjh.1_Missense_Mutation_p.E3390K	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	4002					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GCCACTGCGGGAGCAGAACTG	0.582													18	106					0	0	0	0	A	73828456	A	A	73828456	3	1	216	1	0	0	0	0	1	0	0	0	535	1175	41	2	12078	2	ALMS1	2	73828456	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08		73828456	169370917	25	39749											
PROM2	150696	broad.mit.edu	37	chr2	95941259	95941259	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctccgtgaaggtgaatgagGtgagcaagctggggaaaggt	11	7	17	6	1	0	4	0	4	0	0	1	5	1	5	2	5	2	2	2	5	4	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr2:95941259G>T	uc002suh.1	+	2	427	c.294_splice	c.e2+1	p.E98_splice	PROM2_uc002sui.2_Splice_Site_p.E98_splice|PROM2_uc002suj.2_Splice_Site|PROM2_uc002suk.2_Splice_Site_p.E98_splice|PROM2_uc002sul.2_Splice_Site	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor							apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GGTGAATGAGGTGAGCAAGCT	0.602													5	45					0.00116845	0.00220471	1	0	T	95941259	T	T	95941259	5	4	216	1	0	0	0	0	0	0	1	0	12618	1275	44	4	301	4	PROM2	2	95941259	Splice_Site	SNP	G	TCGA-CV-7089-01A-11D-2012-08	22112803	95941259	147258114	26	39750											
PSD4	23550	broad.mit.edu	37	chr2	113943603	113943603	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccagccctgcatcgtcccagGagggcagcccgcagcttcaa	8	5	11	17	2	1	0	1	0	0	0	3	1	2	1	4	2	4	4	4	2	1	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr2:113943603G>C	uc002tjc.2	+	5	1582	c.1399G>C	c.(1399-1401)GAG>CAG	p.E467Q	PSD4_uc002tjd.2_Missense_Mutation_p.E88Q|PSD4_uc002tje.2_Missense_Mutation_p.E438Q|PSD4_uc002tjf.2_Missense_Mutation_p.E88Q	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	467					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						ATCGTCCCAGGAGGGCAGCCC	0.617													8	59					0	0	0	0	C	113943603	C	C	113943603	3	2	216	1	0	0	0	0	1	0	0	0	12711	1175	41	2	1413	2	PSD4	2	113943603	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	18002344	113943603	129255770	27	39751											
TMEM177	80775	broad.mit.edu	37	chr2	120439337	120439337	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctgtgctgcagatgtggaGggggatgctcaatccgggcc	6	9	16	10	1	2	1	1	0	1	1	3	3	3	3	2	4	3	3	2	4	1	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr2:120439337G>C	uc010flg.1	+	2	1381	c.908G>C	c.(907-909)AGG>ACG	p.R303T	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Missense_Mutation_p.R303T|TMEM177_uc002tmd.2_Missense_Mutation_p.R303T|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	303						integral to membrane				ovary(1)	1	Colorectal(110;0.196)					CAGATGTGGAGGGGGATGCTC	0.577													9	80					0	0	0	0	C	120439337	C	C	120439337	3	2	216	1	0	0	0	0	1	0	0	0	16160	1000	35	4	910	4	TMEM177	2	120439337	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	6495734	120439337	122760036	28	39752											
SCN1A	6323	broad.mit.edu	37	chr2	166854606	166854606	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caataaacaggttcaaggtgAagaaggacccaaagatgatg	18	6	11	6	0	1	4	1	2	0	2	1	5	1	5	1	3	1	1	1	3	7	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr2:166854606A>G	uc010zcz.1	-	23	4403	c.4385T>C	c.(4384-4386)TTC>TCC	p.F1462S	SCN1A_uc002udo.3_Missense_Mutation_p.F1342S|SCN1A_uc010fpk.2_Missense_Mutation_p.F1314S	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1473	Helical; Name=S6 of repeat III; (By similarity).|III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GTTCAAGGTGAAGAAGGACCC	0.343													4	39					0	0	0	0	G	166854606	G	G	166854606	3	3	216	1	0	0	0	0	1	0	0	0	13979	246	9	5	1627	5	SCN1A	2	166854606	Missense_Mutation	SNP	A	TCGA-CV-7089-01A-11D-2012-08	46415269	166854606	76344767	29	39753											
TTC30A	92104	broad.mit.edu	37	chr2	178481760	178481760	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taccaaactcatagtttcctTtggcacaataaagagttcct	13	13	5	10	0	1	1	1	0	0	1	3	1	3	1	3	1	2	3	3	1	6	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr2:178481760T>C	uc002ulo.2	-	1	1935	c.1670A>G	c.(1669-1671)AAA>AGA	p.K557R		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	557	TPR 8.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			ATAGTTTCCTTTGGCACAATA	0.383													4	242					0	0	0	0	C	178481760	C	C	178481760	3	2	216	1	0	0	0	0	1	0	0	0	16766	1841	64	5	331	5	TTC30A	2	178481760	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	11627154	178481760	64717613	30	39754											
TTN	7273	broad.mit.edu	37	chr2	179440094	179440094	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagattcctcacaacacattCtaaccctttcacggttgtga	11	13	5	12	1	3	2	2	1	1	1	4	2	4	2	2	1	2	1	2	1	3	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr2:179440094C>G	uc010zfg.1	-	275	63285	c.63061G>C	c.(63061-63063)GAA>CAA	p.E21021Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E14716Q|TTN_uc010zfi.1_Missense_Mutation_p.E14649Q|TTN_uc010zfj.1_Missense_Mutation_p.E14524Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21948							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAACACATTCTAACCCTTTC	0.507													11	67					0	0	0	0	G	179440094	G	G	179440094	3	3	216	1	0	0	0	0	1	0	0	0	16803	922	32	2	37362	2	TTN	2	179440094	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	958334	179440094	63759279	31	39755											
CWC22	57703	broad.mit.edu	37	chr2	180838488	180838488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaacatgggtgaagattggaGaagcactctgtgcttgcaaa	14	9	12	6	0	1	3	0	1	1	2	1	4	1	3	0	2	4	3	0	2	4	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr2:180838488G>A	uc010frh.1	-	7	923	c.623C>T	c.(622-624)TCT>TTT	p.S208F	CWC22_uc002unp.2_Missense_Mutation_p.S208F	NM_020943	NP_065994	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog	208	MIF4G.					catalytic step 2 spliceosome	protein binding|RNA binding				0						GAAGATTGGAGAAGCACTCTG	0.328													7	50					0	0	0	0	A	180838488	A	A	180838488	3	1	216	1	0	0	0	0	1	0	0	0	4085	942	33	2	2159	2	CWC22	2	180838488	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	1398394	180838488	62360885	32	39756											
SLC4A3	6508	broad.mit.edu	37	chr2	220496825	220496825	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagaagaaaaagctggaccGgaggcctcatgaggtcagga	15	4	15	7	1	2	3	2	1	0	2	2	7	2	6	2	5	1	1	2	5	4	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr2:220496825G>A	uc002vmp.3	+	7	1216	c.947G>A	c.(946-948)CGG>CAG	p.R316Q	SLC4A3_uc002vmn.2_Missense_Mutation_p.R343Q|SLC4A3_uc002vmo.3_Missense_Mutation_p.R343Q|SLC4A3_uc010fwm.2_5'UTR|SLC4A3_uc010fwn.1_5'UTR	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	316	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGCTGGACCGGAGGCCTCAT	0.652													4	54					0	0	0	0	A	220496825	A	A	220496825	3	1	216	1	0	0	0	0	1	0	0	0	14719	1116	39	1	1050	1	SLC4A3	2	220496825	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	39658337	220496825	22702548	33	39757											
UGT1A6	54578	broad.mit.edu	37	chr2	234602064	234602064	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacagggacaccctgaacttCtttaaggagagcaagtttga	13	9	11	8	0	1	3	0	2	1	1	1	6	1	4	1	2	2	2	1	2	3	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr2:234602064C>G	uc002vuv.3	+	1	553	c.414C>G	c.(412-414)TTC>TTG	p.F138L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Missense_Mutation_p.F138L	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	138					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		CCCTGAACTTCTTTAAGGAGA	0.488													10	73					0	0	0	0	G	234602064	G	G	234602064	3	3	216	1	0	0	0	0	1	0	0	0	17017	912	32	2	416	2	UGT1A6	2	234602064	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	14105239	234602064	8597309	34	39758											
PBRM1	55193	broad.mit.edu	37	chr3	52623229	52623229	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtatgtgcgatgtaagcctGagaggcctgcagcaccagag	10	8	14	9	1	0	2	0	1	0	2	0	4	0	2	3	1	4	4	3	1	2	2	rs141067977	by1000genomes	TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:52623229G>C	uc003des.2	-	18	2834	c.2822C>G	c.(2821-2823)TCA>TGA	p.S941*	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Nonsense_Mutation_p.S941*|PBRM1_uc003der.2_Nonsense_Mutation_p.S909*|PBRM1_uc003det.2_Nonsense_Mutation_p.S956*|PBRM1_uc003deu.2_Nonsense_Mutation_p.S956*|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Nonsense_Mutation_p.S941*|PBRM1_uc010hmk.1_Nonsense_Mutation_p.S941*|PBRM1_uc003dey.2_Nonsense_Mutation_p.S941*|PBRM1_uc003dez.1_Nonsense_Mutation_p.S940*|PBRM1_uc003dfb.1_Nonsense_Mutation_p.S853*|PBRM1_uc003dfa.1_Nonsense_Mutation_p.S287*	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	941					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		ATGTAAGCCTGAGAGGCCTGC	0.428			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								13	110					0	0	0	0	C	52623229	C	C	52623229	4	2	216	1	0	0	0	0	0	1	0	0	11545	1294	45	2	2130	2	PBRM1	3	52623229	Nonsense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08		52623229	145399201	35	39759											
PRICKLE2	166336	broad.mit.edu	37	chr3	64132920	64132920	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcactggctgaggagctgcaGagggctctgggtctggttct	5	10	17	9	0	3	2	0	1	3	1	3	3	3	3	0	5	2	6	0	5	0	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:64132920G>C	uc003dmf.2	-	7	1832	c.1246C>G	c.(1246-1248)CTG>GTG	p.L416V		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	416						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		AGGAGCTGCAGAGGGCTCTGG	0.612													21	93					0	0	0	0	C	64132920	C	C	64132920	3	2	216	1	0	0	0	0	1	0	0	0	12549	933	33	2	1296	2	PRICKLE2	3	64132920	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	11509691	64132920	133889510	36	39760											
PROS1	5627	broad.mit.edu	37	chr3	93617301	93617301	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaatgtttacctcacaactCttctgatcttgggcaagttt	11	15	6	9	0	4	1	1	1	3	0	4	1	4	1	1	1	2	3	1	1	5	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:93617301C>G	uc003drb.3	-	8	1181	c.840G>C	c.(838-840)AAG>AAC	p.K280N	PROS1_uc010hoo.2_Missense_Mutation_p.K149N|PROS1_uc003dqz.3_Missense_Mutation_p.K149N	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	280	EGF-like 4; calcium-binding (Potential).				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	CCTCACAACTCTTCTGATCTT	0.383													5	64					0	0	0	0	G	93617301	G	G	93617301	3	3	216	1	0	0	0	0	1	0	0	0	12620	912	32	2	1222	2	PROS1	3	93617301	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	29484381	93617301	104405129	37	39761											
ARHGAP31	57514	broad.mit.edu	37	chr3	119134182	119134182	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacctggaatgcaggtctctGagccaggagacccaaaggtc	11	6	12	12	0	1	2	0	1	1	1	3	4	1	3	3	4	2	1	3	4	2	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:119134182G>A	uc003ecj.3	+	12	3938	c.3406G>A	c.(3406-3408)GAG>AAG	p.E1136K		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1136					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						GCAGGTCTCTGAGCCAGGAGA	0.532													6	74					0	0	0	0	A	119134182	A	A	119134182	3	1	216	1	0	0	0	0	1	0	0	0	880	1291	45	2	3452	2	ARHGAP31	3	119134182	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	25516881	119134182	78888248	38	39762											
KBTBD12	166348	broad.mit.edu	37	chr3	127646718	127646718	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgttataggaggacagatGaaaattaaaaaccagtatct	18	11	8	4	0	1	2	0	1	1	1	1	4	1	4	1	2	1	2	1	2	9	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:127646718G>A	uc010hsr.2	+	2	1185	c.1182G>A	c.(1180-1182)ATG>ATA	p.M394I	KBTBD12_uc003ejy.3_Missense_Mutation_p.M1I|KBTBD12_uc010hsq.2_Intron|KBTBD12_uc003eka.3_Intron|KBTBD12_uc003ejz.2_Missense_Mutation_p.M394I	NM_207335	NP_997218	Q3ZCT8	KBTBC_HUMAN	kelch domain containing 6	394	Kelch 1.									ovary(1)	1						GAGGACAGATGAAAATTAAAA	0.393													20	146					0	0	0	0	A	127646718	A	A	127646718	3	1	216	1	0	0	0	0	1	0	0	0	8030	1290	45	2	1188	2	KBTBD12	3	127646718	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	8512536	127646718	70375712	39	39763											
PIK3R4	30849	broad.mit.edu	37	chr3	130452968	130452968	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggctcacggtgaatcatctGagttacctataccaagggaa	12	10	10	9	1	3	2	2	2	1	0	3	3	3	3	2	3	2	2	2	3	6	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:130452968G>C	uc003enj.2	-	4	1455	c.874C>G	c.(874-876)CAG>GAG	p.Q292E		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	292	Protein kinase.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TGAATCATCTGAGTTACCTAT	0.348													9	65					0	0	0	0	C	130452968	C	C	130452968	3	2	216	1	0	0	0	0	1	0	0	0	11976	1299	45	2	3270	2	PIK3R4	3	130452968	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	2806250	130452968	67569462	40	39764											
PIK3R4	30849	broad.mit.edu	37	chr3	130463505	130463505	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcctccgtgatgtgtcaaaGaaataattgaaatctgccgg	12	11	9	9	2	2	3	1	2	1	1	4	3	4	3	3	1	1	0	3	1	4	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:130463505G>C	uc003enj.2	-	2	1139	c.558C>G	c.(556-558)TTC>TTG	p.F186L		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	186	Protein kinase.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						ATGTGTCAAAGAAATAATTGA	0.408													11	48					0	0	0	0	C	130463505	C	C	130463505	3	2	216	1	0	0	0	0	1	0	0	0	11976	933	33	2	3594	2	PIK3R4	3	130463505	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	10537	130463505	67558925	41	39765											
ZBTB38	253461	broad.mit.edu	37	chr3	141163924	141163924	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccaatccgagtgcatggaGatgagtgaagtgttcgatga	11	10	14	6	2	0	4	0	3	0	1	2	7	1	4	2	1	2	2	2	1	2	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:141163924G>T	uc003etw.2	+	8	3676	c.2694G>T	c.(2692-2694)GAG>GAT	p.E898D	ZBTB38_uc010hun.2_Missense_Mutation_p.E895D|ZBTB38_uc010huo.2_Missense_Mutation_p.E898D|ZBTB38_uc003ety.2_Missense_Mutation_p.E898D|ZBTB38_uc010hup.2_Missense_Mutation_p.E899D	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	898					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AGTGCATGGAGATGAGTGAAG	0.522													16	49					6.72482e-11	1.36793e-10	1	0	T	141163924	T	T	141163924	3	4	216	1	0	0	0	0	1	0	0	0	17606	933	33	2	2696	2	ZBTB38	3	141163924	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	10700419	141163924	56858506	42	39766											
AGTR1	185	broad.mit.edu	37	chr3	148459824	148459824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaacctttcaacaaaaatGagcacgctttcctaccgccc	13	9	4	15	2	2	1	2	1	0	0	3	1	3	1	4	0	4	2	4	0	5	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:148459824G>A	uc003ewg.2	+	4	1448	c.1002G>A	c.(1000-1002)ATG>ATA	p.M334I	AGTR1_uc003ewh.2_Missense_Mutation_p.M334I|AGTR1_uc003ewi.2_Missense_Mutation_p.M334I|AGTR1_uc003ewj.2_Missense_Mutation_p.M334I|AGTR1_uc003ewk.2_Missense_Mutation_p.M334I	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	334	Cytoplasmic (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	CAACAAAAATGAGCACGCTTT	0.403													7	44					0	0	0	0	A	148459824	A	A	148459824	3	1	216	1	0	0	0	0	1	0	0	0	401	1290	45	2	1004	2	AGTR1	3	148459824	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	7295900	148459824	49562606	43	39767											
SI	6476	broad.mit.edu	37	chr3	164776814	164776814	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatgttgtgtgtttcccctCtcataggttgcatatgttgt	6	18	9	8	0	1	0	1	0	1	0	3	0	2	0	2	1	1	5	2	1	2	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:164776814C>G	uc003fei.2	-	12	1397	c.1335G>C	c.(1333-1335)GAG>GAC	p.E445D		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	445	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGTTTCCCCTCTCATAGGTTG	0.363										HNSCC(35;0.089)			3	48					0	0	0	0	G	164776814	G	G	164776814	3	3	216	1	0	0	0	0	1	0	0	0	14362	912	32	2	4296	2	SI	3	164776814	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	16316990	164776814	33245616	44	39768											
HTR3C	170572	broad.mit.edu	37	chr3	183778119	183778119	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctcctccatccttactgtCattgtcctctggaacaccta	7	13	5	16	0	2	0	1	0	1	0	6	1	6	1	6	1	2	0	6	1	3	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:183778119C>G	uc003fmk.2	+	9	1357	c.1323C>G	c.(1321-1323)GTC>GTG	p.V441V		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine receptor 3 subunit C	441	Helical; Name=4; (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TCCTTACTGTCATTGTCCTCT	0.557													24	183					0	0	0	0	G	183778119	G	G	183778119	2	3	216	1	0	0	0	0	0	0	0	1	7485	813	29	2		2	HTR3C	3	183778119	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	19001305	183778119	14244311	45	39769											
AP2M1	1173	broad.mit.edu	37	chr3	183896841	183896841	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgtgtgacgtgatggctGcctactttggcaagatcagc	9	11	13	8	1	1	4	1	2	0	2	1	4	1	4	1	2	3	2	1	2	2	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:183896841G>C	uc011bqx.1	+	3	428	c.271G>C	c.(271-273)GCC>CCC	p.A91P	AP2M1_uc003fmw.2_Missense_Mutation_p.A91P|AP2M1_uc003fmx.2_Missense_Mutation_p.A91P|AP2M1_uc003fmy.2_Missense_Mutation_p.A91P|AP2M1_uc011bqy.1_5'Flank|AP2M1_uc011bqz.1_5'Flank	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	91					axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CGTGATGGCTGCCTACTTTGG	0.522													3	130					0	0	0	0	C	183896841	C	C	183896841	3	2	216	1	0	0	0	0	1	0	0	0	742	1319	46	4	277	4	AP2M1	3	183896841	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	118722	183896841	14125589	46	39770											
IL1RAP	3556	broad.mit.edu	37	chr3	190362120	190362121	+	Frame_Shift_Ins	INS	-	A	A																															gattctcattgttgtttaccINSatgtttactggctagagatg																										TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:190362120_190362121insA	uc003fsm.1	+	10	1341_1342	c.1135_1136insA	c.(1135-1137)CATfs	p.H379fs	IL1RAP_uc010hzg.1_Frame_Shift_Ins_p.H379fs|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Frame_Shift_Ins_p.H379fs|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Frame_Shift_Ins_p.H379fs	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	379	Helical; (Potential).				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		TGTTGTTTACCATGTTTACTGG	0.416													---	---	---								A	190362121	A	A	190362120	7	5	216	1	0	1	1	0	0	0	0	0	7699	594	21	0	1185	0	IL1RAP	3	190362120	Frame_Shift_Ins	INS	-	TCGA-CV-7089-01A-11D-2012-08	6465279	190362120	7660310	47	39771											
GP5	2814	broad.mit.edu	37	chr3	194118031	194118031	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgccctgcggaagcgcgctCagccgcgggctcagagtcac	6	4	15	16	6	3	1	3	0	0	1	3	2	3	2	2	2	3	2	2	2	1	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr3:194118031C>G	uc003ftv.1	-	2	1012	c.981G>C	c.(979-981)CTG>CTC	p.L327L		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	327	Extracellular (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		GAAGCGCGCTCAGCCGCGGGC	0.726													3	22					0	0	0	0	G	194118031	G	G	194118031	2	3	216	1	0	0	0	0	0	0	0	1	6621	813	29	2		2	GP5	3	194118031	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	3755911	194118031	3904399	48	39772											
KIAA1530	57654	broad.mit.edu	37	chr4	1360143	1360143	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgcggaggaagatgaggaCgatgaggactttgtggaggt	11	8	19	3	2	0	3	0	2	0	1	0	10	0	8	0	6	1	0	0	6	1	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr4:1360143C>T	uc003gde.3	+	8	1659	c.1212C>T	c.(1210-1212)GAC>GAT	p.D404D	KIAA1530_uc010ibv.2_Translation_Start_Site	NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	404											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			AAGATGAGGACGATGAGGACT	0.587													20	163					0	0	0	0	T	1360143	T	T	1360143	2	4	216	1	0	0	0	0	0	0	0	1	8280	535	19	1		1	KIAA1530	4	1360143	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08		1360143	189794133	49	39773											
TBC1D1	23216	broad.mit.edu	37	chr4	38134714	38134714	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctataacaggtatttgaaAtggacatcgctaaacagtta	15	13	7	6	1	1	1	0	1	1	0	2	2	1	2	0	2	2	3	0	2	7	7			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr4:38134714A>G	uc003gtb.2	+	19	3485	c.3142A>G	c.(3142-3144)ATG>GTG	p.M1048V	TBC1D1_uc011byd.1_Missense_Mutation_p.M1039V|TBC1D1_uc010ifd.2_Missense_Mutation_p.M835V|TBC1D1_uc003gtd.2_Missense_Mutation_p.M60V	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	1048						nucleus	Rab GTPase activator activity			ovary(1)	1						GGTATTTGAAATGGACATCGC	0.423													8	51					0	0	0	0	G	38134714	G	G	38134714	3	3	216	1	0	0	0	0	1	0	0	0	15663	101	4	5	3212	5	TBC1D1	4	38134714	Missense_Mutation	SNP	A	TCGA-CV-7089-01A-11D-2012-08	36774571	38134714	153019562	50	39774											
PDS5A	23244	broad.mit.edu	37	chr4	39910122	39910122	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacaatgacatcatgacgaaTagcttcttctggatcatgtg	13	12	8	8	1	4	2	2	2	2	0	4	4	4	3	0	1	2	1	0	1	4	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr4:39910122T>C	uc003guv.3	-	11	1666	c.1126A>G	c.(1126-1128)ATT>GTT	p.I376V	PDS5A_uc010ifo.2_Missense_Mutation_p.I336V|PDS5A_uc003guw.3_Missense_Mutation_p.I376V	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	376					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						TCATGACGAATAGCTTCTTCT	0.353													16	100					0	0	0	0	C	39910122	C	C	39910122	3	2	216	1	0	0	0	0	1	0	0	0	11745	1406	49	5	3012	5	PDS5A	4	39910122	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	1775408	39910122	151244154	51	39775											
MUC7	4589	broad.mit.edu	37	chr4	71346858	71346858	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccaaatgtgacttttcttCcccagaatgccaccaccata	11	12	4	14	0	1	2	0	1	1	1	3	2	3	2	6	0	1	0	6	0	3	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr4:71346858C>A	uc011cat.1	+	4	685	c.397C>A	c.(397-399)CCC>ACC	p.P133T	MUC7_uc011cau.1_Missense_Mutation_p.P133T|MUC7_uc003hfj.2_Missense_Mutation_p.P133T|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	133	Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			GACTTTTCTTCCCCAGAATGC	0.448													13	106					4.3838e-07	8.58237e-07	1	0	A	71346858	A	A	71346858	3	1	216	1	0	0	0	0	1	0	0	0	10034	855	30	2	403	2	MUC7	4	71346858	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	31436736	71346858	119807418	52	39776											
KIAA1109	84162	broad.mit.edu	37	chr4	123230492	123230492	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagtactctcatcactgcAtgctcttcagagtctctggt	9	13	8	11	0	5	1	3	0	3	1	7	2	5	1	0	1	3	3	0	1	2	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr4:123230492A>G	uc003ieh.2	+	57	10170	c.10125A>G	c.(10123-10125)GCA>GCG	p.A3375A	KIAA1109_uc003iel.1_Silent_p.A1310A	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3375					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TCATCACTGCATGCTCTTCAG	0.378													11	62					0	0	0	0	G	123230492	G	G	123230492	2	3	216	1	0	0	0	0	0	0	0	1	8247	204	8	5		5	KIAA1109	4	123230492	Silent	SNP	A	TCGA-CV-7089-01A-11D-2012-08	51883634	123230492	67923784	53	39777											
DCHS2	54798	broad.mit.edu	37	chr4	155254167	155254167	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgtcagcaccagcagggCtgcctgaggatgcacgcctt	8	7	13	13	1	1	1	1	1	0	0	1	3	1	2	3	2	4	4	3	2	0	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr4:155254167C>T	uc003inw.2	-	9	1696	c.1696G>A	c.(1696-1698)GCC>ACC	p.A566T	DCHS2_uc003inx.2_Missense_Mutation_p.A1065T	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	566	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ACCAGCAGGGCTGCCTGAGGA	0.607													9	84					0	0	0	0	T	155254167	T	T	155254167	3	4	216	1	0	0	0	0	1	0	0	0	4305	797	28	4	7218	4	DCHS2	4	155254167	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	32023675	155254167	35900109	54	39778											
FAT1	2195	broad.mit.edu	37	chr4	187541760	187541760	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagctaatgtttcggcctCggtggaattctctttcacta	8	14	9	10	2	2	0	1	0	1	0	5	2	2	1	1	3	1	2	1	3	3	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr4:187541760C>A	uc003izf.2	-	10	6168	c.5980G>T	c.(5980-5982)GAG>TAG	p.E1994*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1994	Extracellular (Potential).|Cadherin 18.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTTTCGGCCTCGGTGGAATTC	0.418										HNSCC(5;0.00058)			101	237					6.65942e-36	1.36797e-35	1	0	A	187541760	A	A	187541760	4	1	216	1	0	0	0	0	0	1	0	0	5721	893	31	3	7858	3	FAT1	4	187541760	Nonsense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	32287593	187541760	3612516	55	39779											
GCNT4	51301	broad.mit.edu	37	chr5	74325189	74325189	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaaatcttgcccacacaagTtgataacatatttccactgg	14	11	6	10	0	1	1	0	1	1	0	2	2	2	1	2	1	2	1	2	1	5	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr5:74325189T>C	uc003kdn.2	-	1	1536	c.674A>G	c.(673-675)AAC>AGC	p.N225S		NM_016591	NP_057675	Q9P109	GCNT4_HUMAN	core 2 beta-1,6-N-acetylglucosaminyltransferase	225	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		CCCACACAAGTTGATAACATA	0.418													4	78					0	0	0	0	C	74325189	C	C	74325189	3	2	216	1	0	0	0	0	1	0	0	0	6338	1725	60	5	691	5	GCNT4	5	74325189	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08		74325189	106590071	56	39780											
CMYA5	202333	broad.mit.edu	37	chr5	79030301	79030301	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccagaaaatgtggctagtCaacacgaacagagaatagca	18	5	10	8	1	1	2	1	0	0	2	1	4	1	2	1	1	4	2	1	1	7	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr5:79030301C>G	uc003kgc.2	+	2	5785	c.5713C>G	c.(5713-5715)CAA>GAA	p.Q1905E		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1905						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGTGGCTAGTCAACACGAACA	0.468													7	42					0	0	0	0	G	79030301	G	G	79030301	3	3	216	1	0	0	0	0	1	0	0	0	3605	827	29	2	5719	2	CMYA5	5	79030301	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	4705112	79030301	101884959	57	39781											
GPR98	84059	broad.mit.edu	37	chr5	90136535	90136535	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgtcatcctaacgccagaGacaggatctttaaattcatt	13	12	7	9	1	3	1	2	0	1	1	4	4	4	2	2	1	1	0	2	1	3	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr5:90136535G>C	uc003kju.2	+	78	16848	c.16752G>C	c.(16750-16752)GAG>GAC	p.E5584D	GPR98_uc003kjt.2_Missense_Mutation_p.E3290D|GPR98_uc003kjw.2_Missense_Mutation_p.E1245D	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5584	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAACGCCAGAGACAGGATCTT	0.428													28	190					0	0	0	0	C	90136535	C	C	90136535	3	2	216	1	0	0	0	0	1	0	0	0	6760	933	33	2	17062	2	GPR98	5	90136535	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	11106234	90136535	90778725	58	39782											
IRF1	3659	broad.mit.edu	37	chr5	131819736	131819736	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatgttcttcagatctgtGaagacacgctgtagactcag	10	12	9	10	1	4	4	2	1	2	3	5	4	5	4	1	0	0	3	1	0	2	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr5:131819736G>A	uc003kxa.2	-	10	1119	c.885C>T	c.(883-885)TTC>TTT	p.F295F	C5orf56_uc010jds.1_Intron|IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Silent_p.F295F	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	295					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		TCAGATCTGTGAAGACACGCT	0.582													5	59					0	0	0	0	A	131819736	A	A	131819736	2	1	216	1	0	0	0	0	0	0	0	1	7866	1281	45	2		2	IRF1	5	131819736	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	41683201	131819736	49095524	59	39783											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139885401	139885401	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagatatagaagcacagtctGaacgaactaaggatactccg	16	7	10	8	2	1	3	0	1	1	2	2	6	2	4	1	1	4	1	1	1	7	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr5:139885401G>C	uc003lfs.1	+	18	3479	c.3355G>C	c.(3355-3357)GAA>CAA	p.E1119Q	ANKHD1_uc003lfq.1_Missense_Mutation_p.E1138Q|ANKHD1_uc003lfr.2_Missense_Mutation_p.E1119Q|ANKHD1_uc003lft.1_Missense_Mutation_p.E330Q|ANKHD1_uc003lfu.1_Missense_Mutation_p.E599Q|ANKHD1_uc003lfv.1_Missense_Mutation_p.E196Q	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1119						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCACAGTCTGAACGAACTAA	0.393													17	149					0	0	0	0	C	139885401	C	C	139885401	3	2	216	1	0	0	0	0	1	0	0	0	629	1291	45	2	3425	2	ANKHD1-EIF4EBP3	5	139885401	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	8065665	139885401	41029859	60	39784											
SLC26A2	1836	broad.mit.edu	37	chr5	149357721	149357721	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcatttttggagtactgtGccttatgattggtgagacag	8	14	14	5	0	0	2	0	2	0	1	0	4	0	3	1	3	2	2	1	3	2	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr5:149357721G>T	uc003lrh.2	+	2	774	c.506G>T	c.(505-507)TGC>TTC	p.C169F		NM_000112	NP_000103	P50443	S26A2_HUMAN	solute carrier family 26 member 2	169	Helical; (Potential).					integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GGAGTACTGTGCCTTATGATT	0.448													18	96					3.41278e-10	6.9084e-10	1	0	T	149357721	T	T	149357721	3	4	216	1	0	0	0	0	1	0	0	0	14581	1319	46	4	508	4	SLC26A2	5	149357721	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	9472320	149357721	31557539	61	39785											
MYLIP	29116	broad.mit.edu	37	chr6	16143386	16143386	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatagcgaagggcagaaactGctcattggggttggacctga	11	8	15	7	1	1	2	1	1	0	1	1	5	1	3	1	4	3	3	1	4	3	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	8e550489-3da4-4a0f-8c20-b649aa5e7648	g.chr6:16143386G>T	uc003nbq.2	+	4	837	c.600G>T	c.(598-600)CTG>CTT	p.L200L	MYLIP_uc003nbr.2_Silent_p.L19L	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	200	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			GGCAGAAACTGCTCATTGGGG	0.433													4	66					0.00024832	0.00047192	1	0	T	16143386	T	T	16143386	2	4	216	1	0	0	0	0	0	0	0	1	10108	1306	46	4		4	MYLIP	6	16143386	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08		16143386	154971681	62	39786											
MAS1L	116511	broad.mit.edu	37	chr6	29454874	29454874	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agagtaggaacatgggggccGagatctgcaccaccgcatag	12	5	14	10	2	1	2	0	0	1	2	1	4	1	3	3	3	2	3	3	3	3	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr6:29454874G>A	uc011dlq.1	-	1	806	c.806C>T	c.(805-807)TCG>TTG	p.S269L		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	269	Helical; Name=6; (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						CATGGGGGCCGAGATCTGCAC	0.512													7	37					0	0	0	0	A	29454874	A	A	29454874	3	1	216	1	0	0	0	0	1	0	0	0	9374	1059	37	1	332	1	MAS1L	6	29454874	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	13311488	29454874	141660193	63	39787											
HLA-DOA	3111	broad.mit.edu	37	chr6	32974913	32974913	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacggtgcccacgaggaaGcccaccaggccgatggccag	10	2	15	14	3	0	0	0	0	0	0	0	4	0	2	5	5	2	0	5	5	1	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr6:32974913G>A	uc003ocr.2	-	4	769	c.693C>T	c.(691-693)GGC>GGT	p.G231G	HLA-DOA_uc010juj.2_Intron|HLA-DOA_uc010jui.2_3'UTR	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	231	Helical; (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						CCACGAGGAAGCCCACCAGGC	0.627													17	107					0	0	0	0	A	32974913	A	A	32974913	2	1	216	1	0	0	0	0	0	0	0	1	7239	958	34	4		4	HLA-DOA	6	32974913	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	3520039	32974913	138140154	64	39788											
KLHL31	401265	broad.mit.edu	37	chr6	53516703	53516703	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgtagcactccacggtgAgcacgtccacgcgctccccg	6	6	12	17	5	0	1	0	1	0	0	3	1	3	1	4	2	2	5	4	2	1	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr6:53516703A>G	uc003pcb.3	-	3	1739	c.1598T>C	c.(1597-1599)CTC>CCC	p.L533P	uc003pcc.1_Missense_Mutation_p.E32G	NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	533	Kelch 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					CTCCACGGTGAGCACGTCCAC	0.736													3	17					0	0	0	0	G	53516703	G	G	53516703	3	3	216	1	0	0	0	0	1	0	0	0	8424	304	11	5	310	5	KLHL31	6	53516703	Missense_Mutation	SNP	A	TCGA-CV-7089-01A-11D-2012-08	20541790	53516703	117598364	65	39789											
TRMT11	60487	broad.mit.edu	37	chr6	126334221	126334221	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttttaggtggaagactagtCtattggttaccggtgtatac	9	15	12	5	1	1	1	0	0	1	1	1	2	1	2	1	4	2	3	1	4	7	8			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr6:126334221C>T	uc003qam.2	+	11	1234	c.1113C>T	c.(1111-1113)GTC>GTT	p.V371V	TRMT11_uc003qan.2_RNA|TRMT11_uc010kev.2_Silent_p.V371V	NM_001031712	NP_001026882	Q7Z4G4	TRM11_HUMAN	tRNA methyltransferase 11	371					tRNA processing		methyltransferase activity|nucleic acid binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0356)		GAAGACTAGTCTATTGGTTAC	0.343													7	30					0	0	0	0	T	126334221	T	T	126334221	2	4	216	1	0	0	0	0	0	0	0	1	16629	900	32	2		2	TRMT11	6	126334221	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	72817518	126334221	44780846	66	39790											
ARID1B	57492	broad.mit.edu	37	chr6	157505453	157505453	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagctccctgaaaaagcagtAtattcagtacctgtttgcct	11	12	8	10	0	1	1	1	1	0	0	2	2	2	1	3	0	4	5	3	0	5	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr6:157505453A>G	uc003qqn.2	+	13	3532	c.3380A>G	c.(3379-3381)TAT>TGT	p.Y1127C	ARID1B_uc003qqo.2_Missense_Mutation_p.Y1087C|ARID1B_uc003qqp.2_Missense_Mutation_p.Y1074C|ARID1B_uc010kjl.2_Missense_Mutation_p.Y272C	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1132	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		AAAAAGCAGTATATTCAGTAC	0.517													13	53					0	0	0	0	G	157505453	G	G	157505453	3	3	216	1	0	0	0	0	1	0	0	0	914	449	16	5	3484	5	ARID1B	6	157505453	Missense_Mutation	SNP	A	TCGA-CV-7089-01A-11D-2012-08	31171232	157505453	13609614	67	39791											
TULP4	56995	broad.mit.edu	37	chr6	158924402	158924402	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctgtacccacccagcctctCctattgcaccctgcccccca	6	8	5	22	0	1	0	0	0	1	0	2	0	1	0	8	0	4	3	8	0	2	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr6:158924402C>T	uc003qrf.2	+	13	5064	c.3707C>T	c.(3706-3708)TCC>TTC	p.S1236F	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	1236					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CCCAGCCTCTCCTATTGCACC	0.607													14	85					0	0	0	0	T	158924402	T	T	158924402	3	4	216	1	0	0	0	0	1	0	0	0	16844	855	30	2	3757	2	TULP4	6	158924402	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	1418949	158924402	12190665	68	39792											
UNC93A	54346	broad.mit.edu	37	chr6	167704889	167704889	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagaatgggacttcttggtaCtgattgtttttcccatgcct	7	16	10	8	0	1	2	0	1	1	1	2	4	2	3	2	2	2	2	2	2	2	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr6:167704889C>A	uc003qvq.2	+	1	87	c.-88C>A	c.(-90--86)TACTG>TAATG		UNC93A_uc003qvr.2_Translation_Start_Site	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1							integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CTTCTTGGTACTGATTGTTTT	0.398													3	25					0.004672	0.00877578	1	0	A	167704889	A	A	167704889	1	1	216	1	0	0	0	0	0	0	0	0	17064	580	20	4		4	UNC93A	6	167704889	Translation_Start_Site	SNP	C	TCGA-CV-7089-01A-11D-2012-08	8780487	167704889	3410178	69	39793											
DNAH11	8701	broad.mit.edu	37	chr7	21775391	21775391	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgtaggtgacacattggCaagtctctctgaggattaca	10	13	10	8	0	2	2	0	2	2	0	3	3	2	3	0	3	1	2	0	3	3	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr7:21775391C>T	uc003svc.2	+	47	7626	c.7595C>T	c.(7594-7596)GCA>GTA	p.A2532V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2532	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GACACATTGGCAAGTCTCTCT	0.413									Kartagener_syndrome				9	88					0	0	0	0	T	21775391	T	T	21775391	3	4	216	1	0	0	0	0	1	0	0	0	4621	710	25	4	7778	4	DNAH11	7	21775391	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08		21775391	137363272	70	39794											
BMPER	168667	broad.mit.edu	37	chr7	34125426	34125426	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcatggctgcgccgcatctCaagggcaagctctgtggtct	6	10	13	12	2	4	0	2	0	3	0	5	0	4	0	1	3	2	4	1	3	2	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr7:34125426C>G	uc011kap.1	+	13	1581	c.1467C>G	c.(1465-1467)CTC>CTG	p.L489L		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	489	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						CGCCGCATCTCAAGGGCAAGC	0.433													9	43					0	0	0	0	G	34125426	G	G	34125426	2	3	216	1	0	0	0	0	0	0	0	1	1471	813	29	2		2	BMPER	7	34125426	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	12350035	34125426	125013237	71	39795											
SUN3	256979	broad.mit.edu	37	chr7	48035654	48035654	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataatatctggaggcatttCatgatttaggaaacctatcc	14	13	7	7	0	2	1	1	1	1	0	3	3	3	3	2	3	1	1	2	3	6	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr7:48035654C>G	uc003tof.2	-	8	764	c.667G>C	c.(667-669)GAA>CAA	p.E223Q	SUN3_uc010kyq.2_Missense_Mutation_p.E123Q|SUN3_uc003tog.2_Missense_Mutation_p.E223Q|SUN3_uc011kcf.1_Missense_Mutation_p.E211Q	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	223	SUN.					integral to membrane				central_nervous_system(1)	1						GGAGGCATTTCATGATTTAGG	0.284													11	73					0	0	0	0	G	48035654	G	G	48035654	3	3	216	1	0	0	0	0	1	0	0	0	15459	835	29	2	422	2	SUN3	7	48035654	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	13910228	48035654	111103009	72	39796											
ELN	2006	broad.mit.edu	37	chr7	73466086	73466086	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccccatctcaacaggtgctgGagcagccggagtcctccctg	7	7	11	16	1	1	0	1	0	1	0	4	2	3	2	5	3	4	2	5	3	1	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr7:73466086G>C	uc003tzw.2	+	16	897	c.806G>C	c.(805-807)GGA>GCA	p.G269A	RFC2_uc011kfa.1_Intron|ELN_uc003tzm.1_RNA|ELN_uc011kfe.1_Missense_Mutation_p.G238A|ELN_uc003tzn.2_Missense_Mutation_p.G269A|ELN_uc003tzz.2_Missense_Mutation_p.G233A|ELN_uc003tzo.2_Missense_Mutation_p.G255A|ELN_uc003tzp.2_Missense_Mutation_p.G225A|ELN_uc003tzq.2_Missense_Mutation_p.G152A|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_Missense_Mutation_p.G269A|ELN_uc003tzt.2_Missense_Mutation_p.G274A|ELN_uc003tzu.2_Missense_Mutation_p.G274A|ELN_uc003tzv.2_Missense_Mutation_p.G259A|ELN_uc003tzx.2_Missense_Mutation_p.G259A|ELN_uc011kff.1_Missense_Mutation_p.G269A|ELN_uc003tzy.2_Missense_Mutation_p.G264A	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	269	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	ACAGGTGCTGGAGCAGCCGGA	0.597			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome				OREG0018112	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	34					0	0	0	0	C	73466086	C	C	73466086	3	2	216	1	0	0	0	0	1	0	0	0	5095	1174	41	2	883	2	ELN	7	73466086	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	25430432	73466086	85672577	73	39797											
ZNF804B	219578	broad.mit.edu	37	chr7	88964913	88964913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataaaagcaagagaaatcaaGagtctttgggcagccctcac	16	7	9	9	0	3	2	2	0	1	2	3	3	3	2	1	1	2	2	1	1	5	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr7:88964913G>A	uc011khi.1	+	4	3155	c.2617G>A	c.(2617-2619)GAG>AAG	p.E873K		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	873						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GAGAAATCAAGAGTCTTTGGG	0.428										HNSCC(36;0.09)			8	60					0	0	0	0	A	88964913	A	A	88964913	3	1	216	1	0	0	0	0	1	0	0	0	18238	943	33	2	2631	2	ZNF804B	7	88964913	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	15498827	88964913	70173750	74	39798											
CCDC132	55610	broad.mit.edu	37	chr7	92987685	92987685	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttgcctgggatcccatatCaataagaaagcaagacaaaa	17	8	8	8	0	1	2	1	0	0	2	2	3	2	3	2	1	2	2	2	1	7	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr7:92987685C>G	uc003umo.2	+	28	2960	c.2832C>G	c.(2830-2832)ATC>ATG	p.I944M	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.I914M|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.I664M	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	944											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			GATCCCATATCAATAAGAAAG	0.383													12	77					0	0	0	0	G	92987685	G	G	92987685	3	3	216	1	0	0	0	0	1	0	0	0	2779	816	29	2	2984	2	CCDC132	7	92987685	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	4022772	92987685	66150978	75	39799											
ZAN	7455	broad.mit.edu	37	chr7	100345255	100345255	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaattacacagccgtgggAcggatacaggtacagagaag	14	6	13	8	2	1	1	1	0	0	1	1	4	1	3	1	3	4	1	1	3	5	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr7:100345255A>G	uc003uwj.2	+	9	1179	c.1014A>G	c.(1012-1014)GGA>GGG	p.G338G	ZAN_uc003uwk.2_Silent_p.G338G|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	338	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CAGCCGTGGGACGGATACAGG	0.448													3	58					0	0	0	0	G	100345255	G	G	100345255	2	3	216	1	0	0	0	0	0	0	0	1	17581	262	10	5		5	ZAN	7	100345255	Silent	SNP	A	TCGA-CV-7089-01A-11D-2012-08	7357570	100345255	58793408	76	39800											
GPR37	2861	broad.mit.edu	37	chr7	124404013	124404013	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctggaaggcattacctctaTatagggcacgatcttgcagg	10	10	11	10	1	2	0	0	0	2	0	2	2	2	1	2	4	2	3	2	4	5	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr7:124404013T>C	uc003vli.2	-	1	1669	c.1018A>G	c.(1018-1020)ATA>GTA	p.I340V		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	340	Helical; Name=3; (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						ATTACCTCTATATAGGGCACG	0.498													34	211					0	0	0	0	C	124404013	C	C	124404013	3	2	216	1	0	0	0	0	1	0	0	0	6729	1406	49	5	831	5	GPR37	7	124404013	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	24058758	124404013	34734650	77	39801											
POT1	25913	broad.mit.edu	37	chr7	124503478	124503479	+	Missense_Mutation	DNP	GC	AA	AA																															caggtcaaaatactgcattgGctgaacatcacacaatttta																										TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr7:124503478_124503479GC>AA	uc003vlm.2	-	8	1072_1073	c.471_472GC>TT	c.(469-474)CAGCCA>CATTCA	p.157_158QP>HS	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.26_27QP>HS|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	157_158					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						TACTGCATTGGCTGAACATCAC	0.406													11	79					0	0	0	0	AA	124503479	AA	AA	124503478	3	1	216	1	0	0	0	0	1	0	0	0	12315	1203	42	4	1480	4	POT1	7	124503478	Missense_Mutation	DNP	GC	TCGA-CV-7089-01A-11D-2012-08	99465	124503478	34635185	78	39802											
ATP6V0A4	50617	broad.mit.edu	37	chr7	138429966	138429966	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtagatcaaacccgtgtaGatggagaagatgcccataag	14	9	11	7	1	1	4	1	0	0	4	1	5	1	4	2	1	2	2	2	1	5	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr7:138429966G>C	uc003vuf.2	-	13	1618	c.1380C>G	c.(1378-1380)ATC>ATG	p.I460M	ATP6V0A4_uc003vug.2_Missense_Mutation_p.I460M|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.I460M	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	460	Helical; (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						AACCCGTGTAGATGGAGAAGA	0.488													9	88					0	0	0	0	C	138429966	C	C	138429966	3	2	216	1	0	0	0	0	1	0	0	0	1172	932	33	2	1178	2	ATP6V0A4	7	138429966	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	13926488	138429966	20708697	79	39803											
KCNB2	9312	broad.mit.edu	37	chr8	73849039	73849039	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacacaaaggactccgccgaCgataatcacctgtcgccaag	14	5	8	14	4	1	0	1	0	0	0	3	3	2	1	4	1	1	0	4	1	4	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr8:73849039C>T	uc003xzb.2	+	3	2037	c.1449C>T	c.(1447-1449)GAC>GAT	p.D483D		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	483	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			ACTCCGCCGACGATAATCACC	0.512													13	111					0	0	0	0	T	73849039	T	T	73849039	2	4	216	1	0	0	0	0	0	0	0	1	8052	535	19	1		1	KCNB2	8	73849039	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08		73849039	72514983	80	39804											
RBM12B	389677	broad.mit.edu	37	chr8	94746869	94746869	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgcctgaagtcctcctcagaAggccgcctgaagtcttcctc	7	9	9	16	2	2	3	1	2	1	1	6	3	5	3	6	1	0	0	6	1	3	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr8:94746869A>G	uc003yfz.2	-	3	1963	c.1770T>C	c.(1768-1770)CCT>CCC	p.P590P		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	590							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CCTCCTCAGAAGGCCGCCTGA	0.617													21	81					0	0	0	0	G	94746869	G	G	94746869	2	3	216	1	0	0	0	0	0	0	0	1	13179	59	3	5		5	RBM12B	8	94746869	Silent	SNP	A	TCGA-CV-7089-01A-11D-2012-08	20897830	94746869	51617153	81	39805											
ZC3H3	23144	broad.mit.edu	37	chr8	144620188	144620188	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaccttgtgctgctgcgtCtccggatgatcttggtgcgg	3	12	13	13	3	2	1	0	1	2	0	3	2	2	2	3	3	4	2	3	3	0	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr8:144620188C>T	uc003yyd.2	-	2	1378	c.1349G>A	c.(1348-1350)AGA>AAA	p.R450K		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	450					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			GCTGCTGCGTCTCCGGATGAT	0.617													9	85					0	0	0	0	T	144620188	T	T	144620188	3	4	216	1	0	0	0	0	1	0	0	0	17636	913	32	2	1541	2	ZC3H3	8	144620188	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	49873319	144620188	1743834	82	39806											
ZNF7	7553	broad.mit.edu	37	chr8	146067676	146067676	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctcaaattctaaaagcctCagacagtccaagccttgttg	13	10	7	11	0	3	1	2	0	1	1	4	1	4	1	3	0	3	2	3	0	4	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr8:146067676C>G	uc003zeg.3	+	5	1321	c.1184C>G	c.(1183-1185)TCA>TGA	p.S395*	ZNF7_uc010mge.2_Nonsense_Mutation_p.S406*|ZNF7_uc011lln.1_Nonsense_Mutation_p.S299*|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Nonsense_Mutation_p.S299*|COMMD5_uc003zel.1_Intron	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	395					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		CTAAAAGCCTCAGACAGTCCA	0.493													7	79					0	0	0	0	G	146067676	G	G	146067676	4	3	216	1	0	0	0	0	0	1	0	0	18169	838	29	2	1198	2	ZNF7	8	146067676	Nonsense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	1447488	146067676	296346	83	39807											
KANK1	23189	broad.mit.edu	37	chr9	711776	711776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagctggaacagctctcccGggcccgaagaagtggcgggg	8	4	16	13	3	1	1	0	0	1	1	2	3	1	2	3	5	3	2	3	5	3	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr9:711776G>A	uc003zgl.1	+	7	1659	c.1010G>A	c.(1009-1011)CGG>CAG	p.R337Q	KANK1_uc003zgm.2_Missense_Mutation_p.R337Q|KANK1_uc003zgn.1_Missense_Mutation_p.R337Q|KANK1_uc003zgo.1_Missense_Mutation_p.R337Q|KANK1_uc003zgp.1_Missense_Mutation_p.R337Q|KANK1_uc003zgq.2_Missense_Mutation_p.R179Q|KANK1_uc003zgr.1_Missense_Mutation_p.R179Q|KANK1_uc003zgs.1_Missense_Mutation_p.R179Q	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	337					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		CAGCTCTCCCGGGCCCGAAGA	0.537													8	91					0	0	0	0	A	711776	A	A	711776	3	1	216	1	0	0	0	0	1	0	0	0	8015	1116	39	1	1016	1	KANK1	9	711776	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08		711776	140501655	84	39808											
TAF1L	138474	broad.mit.edu	37	chr9	32632974	32632974	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgtgcgtttgaagtcagcGcagagctttagcctcttccg	6	12	11	12	3	2	2	1	1	1	1	3	2	3	2	3	0	4	3	3	0	2	4	rs146604611	byFrequency	TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr9:32632974G>A	uc003zrg.1	-	1	2694	c.2604C>T	c.(2602-2604)TGC>TGT	p.C868C	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	868					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TGAAGTCAGCGCAGAGCTTTA	0.468													20	154					0	0	0	0	A	32632974	A	A	32632974	2	1	216	1	0	0	0	0	0	0	0	1	15589	1079	38	1		1	TAF1L	9	32632974	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	31921198	32632974	108580457	85	39809											
UNC13B	10497	broad.mit.edu	37	chr9	35231142	35231142	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttaacacatatgtgaccctGaaagtacagaatgtgaagag	16	10	9	6	0	0	5	0	3	0	2	0	5	0	5	1	0	2	1	1	0	6	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr9:35231142G>A	uc003zwq.2	+	3	370	c.78G>A	c.(76-78)CTG>CTA	p.L26L	UNC13B_uc010mkl.1_Silent_p.L26L|UNC13B_uc003zwr.2_Silent_p.L26L	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	26	C2 1.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			ATGTGACCCTGAAAGTACAGA	0.393													5	33					0	0	0	0	A	35231142	A	A	35231142	2	1	216	1	0	0	0	0	0	0	0	1	17053	1277	45	2		2	UNC13B	9	35231142	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	2598168	35231142	105982289	86	39810											
ZNF782	158431	broad.mit.edu	37	chr9	99581236	99581236	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcccttatgtgaaccttctGatgtacactgaaagttgact	10	14	8	9	0	1	4	0	4	1	0	1	4	1	4	2	0	3	2	2	0	4	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr9:99581236G>A	uc004awp.1	-	6	1350	c.1069C>T	c.(1069-1071)CAG>TAG	p.Q357*	ZNF782_uc011lup.1_Nonsense_Mutation_p.Q225*	NM_001001662	NP_001001662	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	357	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				TGAACCTTCTGATGTACACTG	0.418													31	200					0	0	0	0	A	99581236	A	A	99581236	4	1	216	1	0	0	0	0	0	1	0	0	18222	1299	45	2	1034	2	ZNF782	9	99581236	Nonsense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	64350094	99581236	41632195	87	39811											
RABEPK	10244	broad.mit.edu	37	chr9	127990196	127990196	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttacttttctagacactctGacctggtcacagccagagac	10	12	7	12	0	3	3	1	1	2	2	3	4	3	3	2	1	2	0	2	1	2	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr9:127990196G>T	uc004bpi.2	+	7	707	c.534G>T	c.(532-534)CTG>CTT	p.L178L	RABEPK_uc004bpj.2_Silent_p.L127L|RABEPK_uc004bpk.2_Silent_p.L178L|RABEPK_uc004bpl.1_Silent_p.L127L|RABEPK_uc004bpm.2_Silent_p.L178L	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	178	Kelch 3.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						TAGACACTCTGACCTGGTCAC	0.483													10	68					9.70103e-10	1.95426e-09	1	0	T	127990196	T	T	127990196	2	4	216	1	0	0	0	0	0	0	0	1	13028	1277	45	2		2	RABEPK	9	127990196	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	28408960	127990196	13223235	88	39812											
SLC25A25	114789	broad.mit.edu	37	chr9	130863479	130863479	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctgaggctggtgtttaaGagtttggacaaaaagaatga	15	10	13	3	0	0	4	0	2	0	2	0	5	0	5	0	3	1	4	0	3	5	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr9:130863479G>C	uc004bte.2	+	2	293	c.264G>C	c.(262-264)AAG>AAC	p.K88N	SLC25A25_uc004btb.2_Missense_Mutation_p.K122N|SLC25A25_uc004btc.2_Missense_Mutation_p.K108N|SLC25A25_uc004btd.2_Missense_Mutation_p.K108N|SLC25A25_uc004btf.2_5'UTR	NM_052901	NP_443133	Q6KCM7	SCMC2_HUMAN	solute carrier family 25, member 25 isoform a	88	EF-hand 2.|Mitochondrial intermembrane (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding				0						TGGTGTTTAAGAGTTTGGACA	0.512													13	130					0	0	0	0	C	130863479	C	C	130863479	3	2	216	1	0	0	0	0	1	0	0	0	14552	933	33	2	758	2	SLC25A25	9	130863479	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	2873283	130863479	10349952	89	39813											
GFI1B	8328	broad.mit.edu	37	chr9	135862790	135862790	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caggaccagaacttggccagGatggccccggcaccaggtac	10	4	13	14	1	0	1	0	0	0	1	0	3	0	3	5	6	2	2	5	6	2	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr9:135862790G>C	uc004ccg.2	+	3	373	c.222G>C	c.(220-222)AGG>AGC	p.R74S	GFI1B_uc010mzy.2_Missense_Mutation_p.R74S	NM_004188	NP_004179	Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription	74					cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		ACTTGGCCAGGATGGCCCCGG	0.617													10	35					0	0	0	0	C	135862790	C	C	135862790	3	2	216	1	0	0	0	0	1	0	0	0	6377	1165	41	2	228	2	GFI1B	9	135862790	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	4999311	135862790	5350641	90	39814											
NOTCH1	4851	broad.mit.edu	37	chr9	139402819	139402820	+	Frame_Shift_Del	DEL	CA	-	-																															gttcttgcagggcgaggagtCacaccagtgcacaaggttct																										TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr9:139402819_139402820delCA	uc004chz.2	-	20	3189_3190	c.3189_3190delTG	c.(3187-3192)TGTGACfs	p.C1063fs	NOTCH1_uc004cia.1_Frame_Shift_Del_p.C293fs	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1063_1064	Extracellular (Potential).|EGF-like 28.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGCGAGGAGTCACACCAGTGCA	0.658			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---								-	139402820	-	-	139402819	7	5	216	1	0	1	0	1	0	0	0	0	10601	826	29	0	4537	0	NOTCH1	9	139402819	Frame_Shift_Del	DEL	CA	TCGA-CV-7089-01A-11D-2012-08	3540029	139402819	1810612	91	39815											
NOTCH1	4851	broad.mit.edu	37	chr9	139412690	139412690	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagggttggtgtcgcagttgGagccctcgttacaggggttg	5	11	17	8	2	0	0	0	0	0	0	2	1	0	1	1	5	2	5	1	5	1	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr9:139412690G>A	uc004chz.2	-	7	1154	c.1154C>T	c.(1153-1155)TCC>TTC	p.S385F		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	385	Extracellular (Potential).|EGF-like 10.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTCGCAGTTGGAGCCCTCGTT	0.672			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			7	9					0	0	0	0	A	139412690	A	A	139412690	3	1	216	1	0	0	0	0	1	0	0	0	10601	1174	41	2	6625	2	NOTCH1	9	139412690	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	9871	139412690	1800741	92	39816											
GPR158	57512	broad.mit.edu	37	chr10	25701358	25701358	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagccctgtgtatgctgctcGacttcgttagcatgctggtg	6	13	12	10	2	0	0	0	0	0	0	2	1	0	0	1	1	5	6	1	1	3	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr10:25701358G>A	uc001isj.2	+	4	1351	c.1291G>A	c.(1291-1293)GAC>AAC	p.D431N		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	431	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TATGCTGCTCGACTTCGTTAG	0.488													8	175					0	0	0	0	A	25701358	A	A	25701358	3	1	216	1	0	0	0	0	1	0	0	0	6701	1058	37	1	1305	1	GPR158	10	25701358	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08		25701358	109833389	93	39817											
ZNF33B	7582	broad.mit.edu	37	chr10	43089160	43089160	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcccacatgcattacactgaTagggtttctcccctgtatgt	8	14	7	12	0	1	1	0	1	1	0	3	1	2	1	3	1	2	3	3	1	3	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr10:43089160T>C	uc001jaf.1	-	5	1353	c.1238A>G	c.(1237-1239)TAT>TGT	p.Y413C	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.Y301C|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	413	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ATTACACTGATAGGGTTTCTC	0.423													3	105					0	0	0	0	C	43089160	C	C	43089160	3	2	216	1	0	0	0	0	1	0	0	0	17922	1406	49	5	1102	5	ZNF33B	10	43089160	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	17387802	43089160	92445587	94	39818											
PCDH15	65217	broad.mit.edu	37	chr10	55955577	55955577	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattgtaaaatatggactttGattgttttcatccagtattt	11	19	6	5	0	1	1	1	1	0	0	2	2	2	2	1	1	0	3	1	1	4	9			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr10:55955577G>C	uc001jju.1	-	11	1566	c.1171C>G	c.(1171-1173)CAA>GAA	p.Q391E	PCDH15_uc010qhq.1_Missense_Mutation_p.Q396E|PCDH15_uc010qhr.1_Missense_Mutation_p.Q391E|PCDH15_uc010qhs.1_Missense_Mutation_p.Q396E|PCDH15_uc010qht.1_Missense_Mutation_p.Q391E|PCDH15_uc010qhu.1_Missense_Mutation_p.Q391E|PCDH15_uc001jjv.1_Missense_Mutation_p.Q369E|PCDH15_uc010qhv.1_Missense_Mutation_p.Q391E|PCDH15_uc010qhw.1_Missense_Mutation_p.Q354E|PCDH15_uc010qhx.1_Missense_Mutation_p.Q391E|PCDH15_uc010qhy.1_Missense_Mutation_p.Q396E|PCDH15_uc010qhz.1_Missense_Mutation_p.Q391E|PCDH15_uc010qia.1_Missense_Mutation_p.Q369E|PCDH15_uc010qib.1_Missense_Mutation_p.Q369E|PCDH15_uc001jjw.2_Missense_Mutation_p.Q391E	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	391	Cadherin 3.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TATGGACTTTGATTGTTTTCA	0.393										HNSCC(58;0.16)			6	47					0	0	0	0	C	55955577	C	C	55955577	3	2	216	1	0	0	0	0	1	0	0	0	11565	1299	45	2	6432	2	PCDH15	10	55955577	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	12866417	55955577	79579170	95	39819											
ZWINT	11130	broad.mit.edu	37	chr10	58118574	58118574	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcccgaacttacctctgcagCttgtcccgctcctgttctgc	4	13	7	17	2	2	0	0	0	2	0	5	1	5	0	4	0	5	4	4	0	2	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr10:58118574C>G	uc001jjx.1	-	6	652	c.615G>C	c.(613-615)AAG>AAC	p.K205N	ZWINT_uc001jjy.1_Intron|ZWINT_uc001jka.1_Missense_Mutation_p.K205N|ZWINT_uc009xoy.1_RNA	NM_007057	NP_008988	O95229	ZWINT_HUMAN	ZW10 interactor isoform a	205	Potential.				cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding				0						ACCTCTGCAGCTTGTCCCGCT	0.517													20	138					0	0	0	0	G	58118574	G	G	58118574	3	3	216	1	0	0	0	0	1	0	0	0	18316	796	28	4	230	4	ZWINT	10	58118574	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	2162997	58118574	77416173	96	39820											
DLG5	9231	broad.mit.edu	37	chr10	79570931	79570931	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtcgatgacagatggatgctCcggggtggtggtgccactgc	6	9	17	9	2	0	2	0	1	0	1	2	4	1	3	2	5	3	1	2	5	0	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr10:79570931C>G	uc001jzk.2	-	23	4454	c.4384G>C	c.(4384-4386)GAG>CAG	p.E1462Q	DLG5_uc001jzi.2_Missense_Mutation_p.E217Q|DLG5_uc001jzj.2_Missense_Mutation_p.E877Q|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1462					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GATGGATGCTCCGGGGTGGTG	0.637													14	79					0	0	0	0	G	79570931	G	G	79570931	3	3	216	1	0	0	0	0	1	0	0	0	4580	864	30	2	1415	2	DLG5	10	79570931	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	21452357	79570931	55963816	97	39821											
GRID1	2894	broad.mit.edu	37	chr10	87966143	87966143	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactcgctgtcgtagaacatGacgaacttctgccagcgcag	10	9	10	12	4	1	2	0	1	1	1	3	3	1	2	1	0	5	3	1	0	4	3	rs61744114		TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr10:87966143G>T	uc001kdl.1	-	3	599	c.498C>A	c.(496-498)GTC>GTA	p.V166V	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	166	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CGTAGAACATGACGAACTTCT	0.622										Multiple Myeloma(13;0.14)			11	39					3.03607e-14	6.20609e-14	1	0	T	87966143	T	T	87966143	2	4	216	1	0	0	0	0	0	0	0	1	6810	1277	45	2		2	GRID1	10	87966143	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	8395212	87966143	47568604	98	39822											
SEC31B	25956	broad.mit.edu	37	chr10	102249138	102249138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtaattggtgctgggggCataaatgtctctggcagcta	9	11	14	7	0	1	0	0	0	1	0	2	0	1	0	0	4	2	6	0	4	4	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr10:102249138C>T	uc001krc.1	-	23	3144	c.3042G>A	c.(3040-3042)ATG>ATA	p.M1014I	SEC31B_uc010qpo.1_Missense_Mutation_p.M1013I|SEC31B_uc001krd.1_Missense_Mutation_p.M551I|SEC31B_uc001krf.1_Missense_Mutation_p.M446I|SEC31B_uc001kre.1_Missense_Mutation_p.M446I	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	1014	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		GTGCTGGGGGCATAAATGTCT	0.527													9	43					0	0	0	0	T	102249138	T	T	102249138	3	4	216	1	0	0	0	0	1	0	0	0	14064	710	25	4	513	4	SEC31B	10	102249138	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	14282995	102249138	33285609	99	39823											
RAG1	5896	broad.mit.edu	37	chr11	36597850	36597850	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acaccactggttgtacacctCcaaatacctccagaagttta	13	10	5	13	0	0	1	0	0	0	1	2	1	2	1	5	1	2	3	5	1	5	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr11:36597850C>G	uc001mwu.3	+	2	3120	c.2996C>G	c.(2995-2997)TCC>TGC	p.S999C	RAG1_uc001mwt.2_Intron	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	999					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				TTGTACACCTCCAAATACCTC	0.448									Familial_Hemophagocytic_Lymphohistiocytosis				14	73					0	0	0	0	G	36597850	G	G	36597850	3	3	216	1	0	0	0	0	1	0	0	0	13068	855	30	2	2998	2	RAG1	11	36597850	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08		36597850	98408666	100	39824											
OR5F1	338674	broad.mit.edu	37	chr11	55761664	55761664	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccctgcagcaaaagccccGgctgccatttttaggtagac	11	8	9	13	1	0	1	0	0	0	1	0	1	0	1	4	2	5	4	4	2	5	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr11:55761664G>A	uc010riv.1	-	1	438	c.438C>T	c.(436-438)GCC>GCT	p.A146A		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CAAAAGCCCCGGCTGCCATTT	0.502													7	53					0	0	0	0	A	55761664	A	A	55761664	2	1	216	1	0	0	0	0	0	0	0	1	11212	1103	39	1		1	OR5F1	11	55761664	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	19163814	55761664	79244852	101	39825											
FAM111B	374393	broad.mit.edu	37	chr11	58891901	58891901	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgagagtatctactcagccCtgagtgctaatgactatttc	10	12	9	10	1	2	3	1	2	1	1	3	4	2	3	1	0	3	2	1	0	4	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr11:58891901C>T	uc001nnl.2	+	4	574	c.331C>T	c.(331-333)CTG>TTG	p.L111L	FAM111B_uc001nnm.2_Silent_p.L81L|FAM111B_uc010rko.1_Silent_p.L81L	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	111							catalytic activity			ovary(2)	2						CTACTCAGCCCTGAGTGCTAA	0.343													9	48					0	0	0	0	T	58891901	T	T	58891901	2	4	216	1	0	0	0	0	0	0	0	1	5428	680	24	4		4	FAM111B	11	58891901	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	3130237	58891901	76114615	102	39826											
OR4D6	219983	broad.mit.edu	37	chr11	59224763	59224763	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccactttgctggtggggcAgatatttttttcctctctgt	4	19	9	9	0	1	1	0	0	1	1	4	1	3	1	2	3	1	2	2	3	1	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr11:59224763A>G	uc010rku.1	+	1	330	c.330A>G	c.(328-330)GCA>GCG	p.A110A		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTGGTGGGGCAGATATTTTTT	0.488													23	163					0	0	0	0	G	59224763	G	G	59224763	2	3	216	1	0	0	0	0	0	0	0	1	11112	175	7	5		5	OR4D6	11	59224763	Silent	SNP	A	TCGA-CV-7089-01A-11D-2012-08	332862	59224763	75781753	103	39827											
CPSF7	79869	broad.mit.edu	37	chr11	61196678	61196678	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgaactcctcgtcagcataTatatcaatcaagtccactcc	12	12	4	13	1	3	1	3	1	0	0	7	1	6	1	3	0	2	1	3	0	6	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr11:61196678T>C	uc001nrq.2	-	2	164	c.30A>G	c.(28-30)ATA>ATG	p.I10M	SDHAF2_uc001nrt.2_5'Flank|CPSF7_uc001nro.2_Missense_Mutation_p.I10M|CPSF7_uc001nrp.2_Missense_Mutation_p.I53M|CPSF7_uc001nrr.2_Missense_Mutation_p.I10M|CPSF7_uc001nrs.1_Translation_Start_Site|CPSF7_uc009ynp.2_Missense_Mutation_p.I10M	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	10					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						CGTCAGCATATATATCAATCA	0.483													30	162					0	0	0	0	C	61196678	C	C	61196678	3	2	216	1	0	0	0	0	1	0	0	0	3845	1396	49	5	1417	5	CPSF7	11	61196678	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	1971915	61196678	73809838	104	39828											
SCGB1D1	10648	broad.mit.edu	37	chr11	61957758	61957758	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagcagaataagccaccaTgaggctgtcggtgtgtctcc	10	8	11	12	1	1	2	0	1	1	1	3	2	1	2	3	2	2	2	3	2	2	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr11:61957758T>C	uc001nsz.1	+	1	49	c.2T>C	c.(1-3)ATG>ACG	p.M1T		NM_006552	NP_006543	O95968	SG1D1_HUMAN	lipophilin A precursor	1						extracellular space	binding			skin(1)	1						TAAGCCACCATGAGGCTGTCG	0.577													3	57					0	0	0	0	C	61957758	C	C	61957758	3	2	216	1	0	0	0	0	1	0	0	0	13961	1464	51	5	4	5	SCGB1D1	11	61957758	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	761080	61957758	73048758	105	39829											
NAALADL1	10004	broad.mit.edu	37	chr11	64813736	64813736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggaagctgcggagtgtctCactgtagtcactgactttga	9	11	12	9	1	2	2	2	2	1	0	3	4	2	4	0	2	2	2	0	2	2	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr11:64813736C>T	uc001ocn.2	-	15	1796	c.1780G>A	c.(1780-1782)GAG>AAG	p.E594K	NAALADL1_uc010rnw.1_Missense_Mutation_p.E70K|NAALADL1_uc009ypz.2_RNA	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	594	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						CGGAGTGTCTCACTGTAGTCA	0.612													12	50					0	0	0	0	T	64813736	T	T	64813736	3	4	216	1	0	0	0	0	1	0	0	0	10182	835	29	2	458	2	NAALADL1	11	64813736	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	2855978	64813736	70192780	106	39830											
ALDH3B2	222	broad.mit.edu	37	chr11	67431887	67431887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggctgctgttggagaaggCgtacagggccaggggcttct	6	9	17	9	1	1	1	0	0	1	1	1	2	1	1	1	6	2	5	1	6	2	3	rs147016371	byFrequency	TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr11:67431887C>T	uc001omr.2	-	8	1292	c.853G>A	c.(853-855)GCC>ACC	p.A285T	ALDH3B2_uc001oms.2_Missense_Mutation_p.A285T|ALDH3B2_uc009ysa.1_Missense_Mutation_p.A285T	NM_000695	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3B2	285					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			lung(1)|kidney(1)	2					NADH(DB00157)	TTGGAGAAGGCGTACAGGGCC	0.637													15	124					0	0	0	0	T	67431887	T	T	67431887	3	4	216	1	0	0	0	0	1	0	0	0	500	768	27	1	316	1	ALDH3B2	11	67431887	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	2618151	67431887	67574629	107	39831											
ETS1	2113	broad.mit.edu	37	chr11	128359290	128359290	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcagagggctgctccattcaTacagaacttctggaagtcta	11	10	10	10	0	3	2	1	0	2	2	4	3	4	3	1	2	3	3	1	2	4	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr11:128359290T>C	uc010sbs.1	-	3	614	c.298A>G	c.(298-300)ATG>GTG	p.M100V	ETS1_uc001qej.2_Missense_Mutation_p.M144V|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Missense_Mutation_p.M100V	NM_005238	NP_005229	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	100	PNT.				cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		GCTCCATTCATACAGAACTTC	0.532													18	139					0	0	0	0	C	128359290	C	C	128359290	3	2	216	1	0	0	0	0	1	0	0	0	5299	1406	49	5	1051	5	ETS1	11	128359290	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	60927403	128359290	6647226	108	39832											
NTM	50863	broad.mit.edu	37	chr11	132016253	132016253	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctatgctgggaatgacaagtGgtgcctggatcctcgcgtgg	7	10	15	9	2	0	1	0	1	0	0	2	3	1	3	2	4	2	1	2	4	3	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr11:132016253G>A	uc001qgp.2	+	2	909	c.245G>A	c.(244-246)TGG>TAG	p.W82*	NTM_uc001qgm.2_Nonsense_Mutation_p.W82*|NTM_uc010sch.1_Nonsense_Mutation_p.W73*|NTM_uc010sci.1_Nonsense_Mutation_p.W82*|NTM_uc010scj.1_Nonsense_Mutation_p.W41*|NTM_uc001qgo.2_Nonsense_Mutation_p.W82*|NTM_uc001qgq.2_Nonsense_Mutation_p.W82*	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	82	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						AATGACAAGTGGTGCCTGGAT	0.567													14	61					0	0	0	0	A	132016253	A	A	132016253	4	1	216	1	0	0	0	0	0	1	0	0	10753	1357	47	4	337	4	NTM	11	132016253	Nonsense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	3656963	132016253	2990263	109	39833											
HDAC7	51564	broad.mit.edu	37	chr12	48188581	48188581	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagcggggcctctggcctCaggctgcccatggcccagct	5	6	15	15	1	2	0	1	0	1	0	2	1	2	1	4	6	3	2	4	6	0	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr12:48188581C>T	uc010slo.1	-	12	1615	c.1420G>A	c.(1420-1422)GAG>AAG	p.E474K	HDAC7_uc009zku.2_5'Flank|HDAC7_uc001rqe.2_5'Flank|HDAC7_uc001rqj.3_Missense_Mutation_p.E437K|HDAC7_uc001rqk.3_Missense_Mutation_p.E457K	NM_015401	NP_056216	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7 isoform a	435	Transcription repression 2 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		CCTCTGGCCTCAGGCTGCCCA	0.657													11	68					0	0	0	0	T	48188581	T	T	48188581	3	4	216	1	0	0	0	0	1	0	0	0	7051	835	29	2	1615	2	HDAC7	12	48188581	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08		48188581	85663314	110	39834											
C12orf54	121273	broad.mit.edu	37	chr12	48888620	48888620	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccttgatgaccccaaagttGagaagattgcagttcagctc	11	11	9	10	0	1	4	1	3	0	2	3	5	2	4	3	0	2	4	3	0	2	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr12:48888620G>A	uc001rrr.2	+	7	339	c.282G>A	c.(280-282)TTG>TTA	p.L94L	C12orf54_uc009zky.1_RNA	NM_152319	NP_689532	Q6X4T0	CL054_HUMAN	hypothetical protein LOC121273	94											0						CCCCAAAGTTGAGAAGATTGC	0.483													11	120					0	0	0	0	A	48888620	A	A	48888620	2	1	216	1	0	0	0	0	0	0	0	1	1705	1281	45	2		2	C12orf54	12	48888620	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	700039	48888620	84963275	111	39835											
ADCY6	112	broad.mit.edu	37	chr12	49165584	49165584	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccacatagaactcagagaagTtggcaatggaggcaaacata	17	6	10	8	0	1	2	1	0	0	2	1	4	1	3	1	3	2	3	1	3	6	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr12:49165584T>C	uc001rsh.3	-	18	3620	c.2960A>G	c.(2959-2961)AAC>AGC	p.N987S	ADCY6_uc001rsj.3_Missense_Mutation_p.N987S|ADCY6_uc001rsi.3_Missense_Mutation_p.N934S|ADCY6_uc010slw.1_Missense_Mutation_p.N218S	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	987	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CTCAGAGAAGTTGGCAATGGA	0.537													9	56					0	0	0	0	C	49165584	C	C	49165584	3	2	216	1	0	0	0	0	1	0	0	0	298	1725	60	5	562	5	ADCY6	12	49165584	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	276964	49165584	84686311	112	39836											
ACVRL1	94	broad.mit.edu	37	chr12	52309043	52309043	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacatgacctcccgcaactcGagcacgcagctgtggctcat	9	7	10	15	3	1	1	1	1	0	0	3	3	2	1	2	1	3	5	2	1	1	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr12:52309043G>A	uc001rzj.2	+	7	1090	c.807G>A	c.(805-807)TCG>TCA	p.S269S	ACVRL1_uc001rzk.2_Silent_p.S269S|ACVRL1_uc010snm.1_Silent_p.S95S	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	269	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CCCGCAACTCGAGCACGCAGC	0.493									Hereditary_Hemorrhagic_Telangiectasia				9	68					0	0	0	0	A	52309043	A	A	52309043	2	1	216	1	0	0	0	0	0	0	0	1	225	1045	37	1		1	ACVRL1	12	52309043	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	3143459	52309043	81542852	113	39837											
CCT2	10576	broad.mit.edu	37	chr12	69987352	69987352	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgtcatggctattgagcAtgcagattttgcaggtgtgg	7	14	15	5	0	1	2	1	1	0	1	1	2	1	2	0	4	3	4	0	4	1	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr12:69987352A>T	uc001svb.1	+	10	1035	c.941A>T	c.(940-942)CAT>CTT	p.H314L	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Missense_Mutation_p.H314L|CCT2_uc010stl.1_Missense_Mutation_p.H267L	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	314					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			GCTATTGAGCATGCAGATTTT	0.318													9	45					0	0	0	0	T	69987352	T	T	69987352	3	4	216	1	0	0	0	0	1	0	0	0	2968	217	8	5	979	5	CCT2	12	69987352	Missense_Mutation	SNP	A	TCGA-CV-7089-01A-11D-2012-08	17678309	69987352	63864543	114	39838											
NAV3	89795	broad.mit.edu	37	chr12	78224975	78224976	+	5'Flank	INS	-	AG	AG																															agagagagagagagagagacINSagagagagagagagagagag																								rs77759134	by1000genomes	TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr12:78224975_78224976insAG	uc001syp.2	+						NAV3_uc001syo.2_5'Flank	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3							nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						gagagagagacagagagagaga	0.208										HNSCC(70;0.22)			---	---	---								AG	78224976	AG	AG	78224975	6	5	216	0	1	1	1	0	0	0	0	0	10238	493	17	0		0	NAV3	12	78224975	5'Flank	INS	-	TCGA-CV-7089-01A-11D-2012-08	8237623	78224975	55626920	115	39839											
FGD6	55785	broad.mit.edu	37	chr12	95603436	95603436	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttttgggcacacaaatgctGaaggtgatttctttctagac	10	14	10	7	0	2	3	0	2	2	1	2	3	2	3	0	2	1	3	0	2	3	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr12:95603436G>A	uc001tdp.3	-	2	1848	c.1624C>T	c.(1624-1626)CAG>TAG	p.Q542*	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	542					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						CACAAATGCTGAAGGTGATTT	0.423													10	89					0	0	0	0	A	95603436	A	A	95603436	4	1	216	1	0	0	0	0	0	1	0	0	5869	1299	45	2	2748	2	FGD6	12	95603436	Nonsense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	17378461	95603436	38248459	116	39840											
CRY1	1407	broad.mit.edu	37	chr12	107415889	107415889	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctgggaaacacatctgcTggttgtccacgaatcacaaa	13	8	9	11	1	2	0	1	0	1	0	3	2	3	1	2	2	3	2	2	2	3	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr12:107415889T>C	uc001tmi.3	-	2	1099	c.240A>G	c.(238-240)CCA>CCG	p.P80P		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	80	DNA photolyase.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						ACACATCTGCTGGTTGTCCAC	0.323													22	127					0	0	0	0	C	107415889	C	C	107415889	2	2	216	1	0	0	0	0	0	0	0	1	3918	1567	55	5		5	CRY1	12	107415889	Silent	SNP	T	TCGA-CV-7089-01A-11D-2012-08	11812453	107415889	26436006	117	39841											
RSRC2	65117	broad.mit.edu	37	chr12	122991393	122991393	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaactcaccttaatacccatCaatttcctaaatttgacatt	15	14	1	11	0	2	1	2	1	0	0	3	1	3	1	3	0	2	0	3	0	6	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr12:122991393C>T	uc001ucr.2	-	9	1259	c.1113G>A	c.(1111-1113)TTG>TTA	p.L371L	RSRC2_uc001uco.2_Silent_p.L140L|RSRC2_uc001ucp.2_Silent_p.L312L|RSRC2_uc001ucq.2_Silent_p.L139L|RSRC2_uc001ucs.2_Silent_p.L140L|RSRC2_uc001uct.2_Silent_p.L323L|RSRC2_uc001ucu.2_Silent_p.L372L	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	371										ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		TAATACCCATCAATTTCCTAA	0.289													12	116					0	0	0	0	T	122991393	T	T	122991393	2	4	216	1	0	0	0	0	0	0	0	1	13780	825	29	2		2	RSRC2	12	122991393	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	15575504	122991393	10860502	118	39842											
NCOR2	9612	broad.mit.edu	37	chr12	124832798	124832798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgcttgggggcggccgtctCatgggggggtcctgagctgc	2	8	20	11	3	1	1	1	1	1	0	3	1	2	1	2	6	2	2	2	6	0	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr12:124832798C>T	uc010tba.1	-	29	4048	c.3931G>A	c.(3931-3933)GAG>AAG	p.E1311K	NCOR2_uc010tay.1_Missense_Mutation_p.E1310K|NCOR2_uc010taz.1_Missense_Mutation_p.E1294K|NCOR2_uc010tbb.1_Missense_Mutation_p.E1303K|NCOR2_uc010tbc.1_Missense_Mutation_p.E1293K|NCOR2_uc001ugj.1_Missense_Mutation_p.E1311K	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1311					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCGGCCGTCTCATGGGGGGGT	0.622											OREG0022238	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	61					0	0	0	0	T	124832798	T	T	124832798	3	4	216	1	0	0	0	0	1	0	0	0	10290	835	29	2	3713	2	NCOR2	12	124832798	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	1841405	124832798	9019097	119	39843											
BRCA2	675	broad.mit.edu	37	chr13	32972546	32972546	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcacagaaggcatttcAgccaccaaggagttgtggca	11	7	13	10	0	1	1	1	0	0	1	1	2	1	2	2	4	2	5	2	4	2	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr13:32972546A>G	uc001uub.1	+	27	10123	c.9896A>G	c.(9895-9897)CAG>CGG	p.Q3299R		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3299					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAGGCATTTCAGCCACCAAGG	0.398			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			3	93					0	0	0	0	G	32972546	G	G	32972546	3	3	216	1	0	0	0	0	1	0	0	0	1504	188	7	5	9998	5	BRCA2	13	32972546	Missense_Mutation	SNP	A	TCGA-CV-7089-01A-11D-2012-08		32972546	82197332	120	39844											
NEK3	4752	broad.mit.edu	37	chr13	52709904	52709904	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtttgaaaagccaagctgaGatcagcattcttaaggatgt	13	12	10	6	0	2	2	1	2	1	1	2	4	2	3	1	1	3	3	1	1	4	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr13:52709904G>C	uc001vgi.2	-	16	1505	c.1270C>G	c.(1270-1272)CTC>GTC	p.L424V	NEK3_uc001vgg.2_Missense_Mutation_p.L401V|NEK3_uc001vgh.2_Missense_Mutation_p.L428V|NEK3_uc010tgx.1_RNA|NEK3_uc010tgy.1_Missense_Mutation_p.L407V	NM_152720	NP_689933	P51956	NEK3_HUMAN	NIMA-related kinase 3 isoform a	424					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		GCCAAGCTGAGATCAGCATTC	0.358													7	39					0	0	0	0	C	52709904	C	C	52709904	3	2	216	1	0	0	0	0	1	0	0	0	10379	942	33	2	262	2	NEK3	13	52709904	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	19737358	52709904	62459974	121	39845											
ZIC5	85416	broad.mit.edu	37	chr13	100617654	100617654	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtatcgtccgcacaacttCagggttcccgtaaatttcct	9	13	7	12	3	1	0	1	0	0	0	5	0	4	0	3	1	1	4	3	1	4	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr13:100617654C>T	uc001vom.1	-	2	2218	c.1969G>A	c.(1969-1971)GAA>AAA	p.E657K		NM_033132	NP_149123	Q96T25	ZIC5_HUMAN	zinc finger protein of the cerebellum 5	657					cell differentiation	nucleus	DNA binding|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CGCACAACTTCAGGGTTCCCG	0.478													13	69					0	0	0	0	T	100617654	T	T	100617654	3	4	216	1	0	0	0	0	1	0	0	0	17749	835	29	2	26	2	ZIC5	13	100617654	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	47907750	100617654	14552224	122	39846											
OR4K15	81127	broad.mit.edu	37	chr14	20443780	20443780	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaatcattctcgggtgacaGaatttgtgttgctgggactg	9	13	12	7	1	2	2	1	1	1	1	3	3	2	3	0	2	1	2	0	2	2	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr14:20443780G>A	uc010tkx.1	+	1	103	c.103G>A	c.(103-105)GAA>AAA	p.E35K		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	35	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCGGGTGACAGAATTTGTGTT	0.398													12	101					0	0	0	0	A	20443780	A	A	20443780	3	1	216	1	0	0	0	0	1	0	0	0	11124	943	33	2	105	2	OR4K15	14	20443780	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08		20443780	86905760	123	39847											
DAAM1	23002	broad.mit.edu	37	chr14	59792758	59792758	+	Frame_Shift_Del	DEL	T	-	-																															catagtgaagcttacccgcaTttcatgtccatcctgcacca																										TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr14:59792758delT	uc001xdz.1	+	10	1262	c.1137delT	c.(1135-1137)CATfs	p.H379fs	DAAM1_uc001xea.1_Frame_Shift_Del_p.H379fs|DAAM1_uc001xeb.1_Frame_Shift_Del_p.H379fs	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	379	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CTTACCCGCATTTCATGTCCA	0.443													---	---	---								-	59792758	-	-	59792758	7	5	216	1	0	1	0	1	0	0	0	0	4232	1490	52	0	1171	0	DAAM1	14	59792758	Frame_Shift_Del	DEL	T	TCGA-CV-7089-01A-11D-2012-08	39348978	59792758	47556782	124	39848											
SYNE2	23224	broad.mit.edu	37	chr14	64564717	64564717	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgagtttgaaccagagaaaAgaagacctgttggtggactt	13	10	12	6	0	0	5	0	2	0	3	0	7	0	6	2	2	1	2	2	2	4	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr14:64564717A>G	uc001xgm.2	+	62	12389	c.12159A>G	c.(12157-12159)AAA>AAG	p.K4053K	SYNE2_uc001xgl.2_Silent_p.K4053K|SYNE2_uc010apy.2_Silent_p.K438K|SYNE2_uc010apx.1_Silent_p.K445K|MIR548H-1_hsa-mir-548h-1|MI0006411_5'Flank|SYNE2_uc010apz.1_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4053	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ACCAGAGAAAAGAAGACCTGT	0.448													11	81					0	0	0	0	G	64564717	G	G	64564717	2	3	216	1	0	0	0	0	0	0	0	1	15512	69	3	5		5	SYNE2	14	64564717	Silent	SNP	A	TCGA-CV-7089-01A-11D-2012-08	4771959	64564717	42784823	125	39849											
CEP152	22995	broad.mit.edu	37	chr15	49054667	49054667	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccccttgatggctatgtccTtctcttgttctaagttttgc	4	18	7	12	0	2	1	0	1	2	0	4	1	3	1	3	1	1	3	3	1	2	8			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr15:49054667T>C	uc001zwy.2	-	18	2517	c.2483A>G	c.(2482-2484)AAG>AGG	p.K828R	CEP152_uc001zwz.2_Missense_Mutation_p.K828R|CEP152_uc001zxa.1_Missense_Mutation_p.K735R	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	828					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		GGCTATGTCCTTCTCTTGTTC	0.373													40	70					0	0	0	0	C	49054667	C	C	49054667	3	2	216	1	0	0	0	0	1	0	0	0	3263	1609	56	5	2517	5	CEP152	15	49054667	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08		49054667	53476725	126	39850											
PIGB	9488	broad.mit.edu	37	chr15	55622047	55622047	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggaaggttcaaagtctatGaacaggtaagaaaaattatt	17	12	9	3	0	2	2	1	1	1	1	2	3	2	3	0	3	1	2	0	3	8	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr15:55622047G>A	uc002act.2	+	5	964	c.648G>A	c.(646-648)ATG>ATA	p.M216I	PIGB_uc010ugg.1_Missense_Mutation_p.M21I	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	216					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		CAAAGTCTATGAACAGGTAAG	0.308													23	53					0	0	0	0	A	55622047	A	A	55622047	3	1	216	1	0	0	0	0	1	0	0	0	11940	1290	45	2	666	2	PIGB	15	55622047	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	6567380	55622047	46909345	127	39851											
VPS13C	54832	broad.mit.edu	37	chr15	62256970	62256970	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttagcaacacttatgctttGatcatcagatggaataatgg	13	13	8	7	0	2	2	2	1	0	1	2	3	2	3	0	2	3	2	0	2	5	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr15:62256970G>C	uc002agz.2	-	31	3216	c.3142C>G	c.(3142-3144)CAA>GAA	p.Q1048E	VPS13C_uc002aha.2_Missense_Mutation_p.Q1005E|VPS13C_uc002ahb.1_Missense_Mutation_p.Q1048E|VPS13C_uc002ahc.1_Missense_Mutation_p.Q1005E	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1048					protein localization					ovary(2)	2						CTTATGCTTTGATCATCAGAT	0.328													22	57					0	0	0	0	C	62256970	C	C	62256970	3	2	216	1	0	0	0	0	1	0	0	0	17259	1299	45	2	8367	2	VPS13C	15	62256970	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	6634923	62256970	40274422	128	39852											
HCN4	10021	broad.mit.edu	37	chr15	73614875	73614875	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcaggcctggccccaggttCcctctggggtccagcagtca	5	8	12	16	0	3	0	2	0	1	0	5	0	5	0	5	5	1	2	5	5	0	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr15:73614875C>T	uc002avp.2	-	8	4553	c.3559G>A	c.(3559-3561)GAA>AAA	p.E1187K		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	1187	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		GCCCCAGGTTCCCTCTGGGGT	0.493													5	15					0	0	0	0	T	73614875	T	T	73614875	3	4	216	1	0	0	0	0	1	0	0	0	7038	864	30	2	56	2	HCN4	15	73614875	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	11357905	73614875	28916517	129	39853											
TSC2	7249	broad.mit.edu	37	chr16	2098710	2098710	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccaaatcccaggtctgcaGagggtaaacagacggagttt	12	7	13	9	1	1	2	0	0	1	2	2	3	2	3	2	4	2	3	2	4	3	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr16:2098710G>C	uc002con.2	+	2	200	c.94G>C	c.(94-96)GAG>CAG	p.E32Q	NTHL1_uc002col.1_5'Flank|NTHL1_uc002com.1_5'Flank|TSC2_uc010uvu.1_Missense_Mutation_p.E32Q|TSC2_uc010bsd.2_Missense_Mutation_p.E32Q|TSC2_uc002coo.2_Missense_Mutation_p.E32Q|TSC2_uc010uvv.1_Missense_Mutation_p.E32Q|TSC2_uc010uvw.1_Intron|TSC2_uc002cop.2_5'UTR	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	32	Required for interaction with TSC1.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CAGGTCTGCAGAGGGTAAACA	0.502			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				9	89					0	0	0	0	C	2098710	C	C	2098710	3	2	216	1	0	0	0	0	1	0	0	0	16673	943	33	2	96	2	TSC2	16	2098710	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08		2098710	88256043	130	39854											
ZNF434	54925	broad.mit.edu	37	chr16	3434561	3434561	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaccatccacagtgccatCttctacctccgtgggttccc	6	11	7	17	1	2	0	0	0	2	0	5	0	5	0	6	1	3	2	6	1	1	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr16:3434561C>T	uc002cuz.2	-	5	1298	c.496G>A	c.(496-498)GAT>AAT	p.D166N	ZNF434_uc002cux.3_Missense_Mutation_p.D377N|ZNF434_uc010uwx.1_Missense_Mutation_p.D89N|ZNF434_uc002cuy.3_Missense_Mutation_p.D89N|ZNF434_uc010uwy.1_Missense_Mutation_p.D89N|ZNF434_uc010uwz.1_Missense_Mutation_p.D377N|ZNF434_uc010uxa.1_Missense_Mutation_p.D166N	NM_017810	NP_060280	Q9NX65	ZN434_HUMAN	zinc finger protein 434	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ACAGTGCCATCTTCTACCTCC	0.527													18	129					0	0	0	0	T	3434561	T	T	3434561	3	4	216	1	0	0	0	0	1	0	0	0	17975	913	32	2	969	2	ZNF434	16	3434561	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	1335851	3434561	86920192	131	39855											
PDXDC1	23042	broad.mit.edu	37	chr16	15130131	15130131	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaccggagagcttaagatGagactcattgtgtggtttga	11	11	14	5	1	1	4	1	2	0	3	1	7	1	5	1	3	1	2	1	3	1	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr16:15130131G>A	uc002dda.3	+	23	2590	c.2366G>A	c.(2365-2367)TGA>TAA	p.*789*	PDXDC1_uc010uzl.1_Silent_p.*774*|PDXDC1_uc010uzm.1_Silent_p.*698*|PDXDC1_uc002ddb.3_Silent_p.*762*|PDXDC1_uc010uzn.1_Silent_p.*761*|PDXDC1_uc002ddc.2_Intron	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	789					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	AGCTTAAGATGAGACTCATTG	0.478													11	85					0	0	0	0	A	15130131	A	A	15130131	2	1	216	1	0	0	0	0	0	0	0	1	11750	1285	45	2		2	PDXDC1	16	15130131	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	11695570	15130131	75224622	132	39856											
ITGAM	3684	broad.mit.edu	37	chr16	31282283	31282283	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccttccccagggtgtcctCaagaggatagtgacattgcc	8	9	10	14	0	1	2	1	1	0	1	3	3	3	3	6	2	1	0	6	2	2	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr16:31282283C>G	uc002ebq.2	+	6	534	c.436C>G	c.(436-438)CAA>GAA	p.Q146E	ITGAM_uc002ebr.2_Missense_Mutation_p.Q146E	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	146	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						AGGGTGTCCTCAAGAGGATAG	0.453													42	216					0	0	0	0	G	31282283	G	G	31282283	3	3	216	1	0	0	0	0	1	0	0	0	7926	827	29	2	458	2	ITGAM	16	31282283	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	16152152	31282283	59072470	133	39857											
ADCY7	113	broad.mit.edu	37	chr16	50348223	50348223	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagctggagcggcagcatgcCcacattggtgtcatggtgga	8	8	16	9	1	1	0	1	0	0	0	1	3	1	2	1	5	4	3	1	5	0	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr16:50348223C>A	uc002egd.1	+	23	3145	c.2877C>A	c.(2875-2877)GCC>GCA	p.A959A		NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	959	Cytoplasmic (Potential).|Guanylate cyclase 2.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	GGCAGCATGCCCACATTGGTG	0.622													5	37					0.00116845	0.00220471	1	0	A	50348223	A	A	50348223	2	1	216	1	0	0	0	0	0	0	0	1	299	610	22	4		4	ADCY7	16	50348223	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	19065940	50348223	40006530	134	39858											
USP6	9098	broad.mit.edu	37	chr17	5048731	5048731	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatctaagaagaaatagatCaattattgtggatttgttcc	14	14	7	6	0	2	3	1	0	1	3	3	4	3	4	2	1	0	1	2	1	6	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:5048731C>T	uc002gau.1	+	27	4254	c.2024C>T	c.(2023-2025)TCA>TTA	p.S675L	USP6_uc002gav.1_Missense_Mutation_p.S675L|USP6_uc010ckz.1_Missense_Mutation_p.S358L	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	675					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						AGAAATAGATCAATTATTGTG	0.358			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								9	62					0	0	0	0	T	5048731	T	T	5048731	3	4	216	1	0	0	0	0	1	0	0	0	17154	838	29	2	2094	2	USP6	17	5048731	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08		5048731	76146479	135	39859											
KIAA0753	9851	broad.mit.edu	37	chr17	6510503	6510503	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagaagcaaatatttacctCtgtttttgcatgctgtcaat	11	16	6	8	0	3	1	2	0	1	1	3	1	3	1	1	0	4	4	1	0	5	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:6510503C>G	uc002gde.3	-	11	2276	c.1917G>C	c.(1915-1917)CAG>CAC	p.Q639H	KIAA0753_uc010vtd.1_Missense_Mutation_p.Q95H|KIAA0753_uc010clo.2_Missense_Mutation_p.Q340H|KIAA0753_uc010vte.1_Missense_Mutation_p.Q340H	NM_014804	NP_055619	Q2KHM9	K0753_HUMAN	hypothetical protein LOC9851	639	Potential.					centrosome					0				COAD - Colon adenocarcinoma(228;0.157)		ATATTTACCTCTGTTTTTGCA	0.373													20	167					0	0	0	0	G	6510503	G	G	6510503	3	3	216	1	0	0	0	0	1	0	0	0	8230	912	32	2	1022	2	KIAA0753	17	6510503	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	1461772	6510503	74684707	136	39860											
BCL6B	255877	broad.mit.edu	37	chr17	6930392	6930392	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgttcgcatccacaccggaGagaagccttaccacgtgggt	10	7	11	13	4	0	1	0	0	0	1	2	3	1	2	4	2	2	2	4	2	2	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:6930392G>C	uc002geg.2	+	8	1366	c.1309G>C	c.(1309-1311)GAG>CAG	p.E437Q	BCL6B_uc010clt.1_Missense_Mutation_p.E438Q	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	437						nucleus	zinc ion binding			skin(1)	1						CCACACCGGAGAGAAGCCTTA	0.632													4	61					0	0	0	0	C	6930392	C	C	6930392	3	2	216	1	0	0	0	0	1	0	0	0	1379	943	33	2	1335	2	BCL6B	17	6930392	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	419889	6930392	74264818	137	39861											
TP53	7157	broad.mit.edu	37	chr17	7578442	7578442	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatgtgctgtgactgcttgTagatggccatggcgcggacg	6	11	15	9	3	1	2	1	1	0	1	1	3	1	3	1	3	2	3	1	3	1	2	rs148924904		TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:7578442T>C	uc002gim.2	-	5	682	c.488A>G	c.(487-489)TAC>TGC	p.Y163C	TP53_uc002gig.1_Missense_Mutation_p.Y163C|TP53_uc002gih.2_Missense_Mutation_p.Y163C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y31C|TP53_uc010cng.1_Missense_Mutation_p.Y31C|TP53_uc002gii.1_Missense_Mutation_p.Y31C|TP53_uc010cnh.1_Missense_Mutation_p.Y163C|TP53_uc010cni.1_Missense_Mutation_p.Y163C|TP53_uc002gij.2_Missense_Mutation_p.Y163C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y70C|TP53_uc002gio.2_Missense_Mutation_p.Y31C|TP53_uc010vug.1_Missense_Mutation_p.Y124C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	163	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y163C(95)|p.Y163N(17)|p.Y163H(17)|p.Y163*(7)|p.0?(7)|p.Y163S(4)|p.Y163Y(3)|p.Y163fs*1(2)|p.Y163D(2)|p.Y163fs*7(2)|p.V157_C176del20(1)|p.Y163_Q165delYKQ(1)|p.P151_V173del23(1)|p.Y163fs*14(1)|p.S149fs*72(1)|p.A159_Q167delAMAIYKQSQ(1)|p.Y163fs*18(1)|p.I162_Y163delIY(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGACTGCTTGTAGATGGCCAT	0.622		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	50					0	0	0	0	C	7578442	C	C	7578442	3	2	216	1	0	0	0	0	1	0	0	0	16448	1638	57	5	810	5	TP53	17	7578442	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	648050	7578442	73616768	138	39862											
ALOX12B	242	broad.mit.edu	37	chr17	7984278	7984278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cacatagctgggcaggccagGaagaaagactcgccagctgc	12	4	13	12	1	0	2	0	0	0	2	1	3	0	3	2	3	3	3	2	3	3	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:7984278G>A	uc002gjy.1	-	4	712	c.451C>T	c.(451-453)CCT>TCT	p.P151S	uc010cnq.1_RNA	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	151	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						GGCAGGCCAGGAAGAAAGACT	0.642										Multiple Myeloma(8;0.094)			6	66					0	0	0	0	A	7984278	A	A	7984278	3	1	216	1	0	0	0	0	1	0	0	0	537	1174	41	2	1702	2	ALOX12B	17	7984278	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	405836	7984278	73210932	139	39863											
MYH1	4619	broad.mit.edu	37	chr17	10408257	10408257	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caaattcttccttcatgttgGccatctccttctctgtctct	5	18	4	14	0	5	0	1	0	4	0	9	0	6	0	3	1	0	1	3	1	1	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:10408257G>T	uc002gmo.2	-	22	2655	c.2561C>A	c.(2560-2562)GCC>GAC	p.A854D	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	854	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CTTCATGTTGGCCATCTCCTT	0.443													18	98					0.000175454	0.000337163	1	0	T	10408257	T	T	10408257	3	4	216	1	0	0	0	0	1	0	0	0	10082	1203	42	4	3334	4	MYH1	17	10408257	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	2423979	10408257	70786953	140	39864											
AKAP10	11216	broad.mit.edu	37	chr17	19850729	19850729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcactgcttacctatgatgtCatttctcattgcttctgtaa	8	17	6	10	0	3	1	2	1	2	0	4	1	3	1	1	0	3	4	1	0	3	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:19850729C>T	uc002gwo.2	-	5	1104	c.967G>A	c.(967-969)GAC>AAC	p.D323N	AKAP10_uc002gwp.1_Missense_Mutation_p.D323N|AKAP10_uc010cqw.1_Missense_Mutation_p.D323N|AKAP10_uc010vze.1_Missense_Mutation_p.D244N	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	323	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					CCTATGATGTCATTTCTCATT	0.323													12	98					0	0	0	0	T	19850729	T	T	19850729	3	4	216	1	0	0	0	0	1	0	0	0	446	826	29	2	1065	2	AKAP10	17	19850729	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	9442472	19850729	61344481	141	39865											
PIP4K2B	8396	broad.mit.edu	37	chr17	36927505	36927505	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagcaggctgtagtccatGatcttcagctgtgccaagaa	11	9	10	11	0	2	2	1	1	1	1	3	2	3	2	3	1	3	4	3	1	3	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:36927505G>C	uc002hqs.2	-	8	1309	c.828C>G	c.(826-828)ATC>ATG	p.I276M	PIP4K2B_uc010cvp.2_5'Flank	NM_003559	NP_003550	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	276	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			ovary(1)	1						TGTAGTCCATGATCTTCAGCT	0.413													8	39					0	0	0	0	C	36927505	C	C	36927505	3	2	216	1	0	0	0	0	1	0	0	0	11992	1280	45	2	434	2	PIP4K2B	17	36927505	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	17076776	36927505	44267705	142	39866											
THRA	7067	broad.mit.edu	37	chr17	38241015	38241022	+	Frame_Shift_Del	DEL	CATCGCAG	-	-																															tccacattgccacagaggccCatcgcagcaccaatgcccag																								rs11545238		TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:38241015_38241022delCATCGCAG	uc002htw.2	+	6	1006_1013	c.523_530delCATCGCAG	c.(523-531)CATCGCAGCfs	p.H175fs	THRA_uc010cwp.1_Frame_Shift_Del_p.H175fs|THRA_uc002htv.2_Frame_Shift_Del_p.H175fs|THRA_uc002htx.2_Frame_Shift_Del_p.H175fs	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	175_177					negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	CACAGAGGCCCATCGCAGCACCAATGCC	0.601													---	---	---								-	38241022	-	-	38241015	7	5	216	1	0	1	0	1	0	0	0	0	15939	594	21	0	541	0	THRA	17	38241015	Frame_Shift_Del	DEL	CATCGCAG	TCGA-CV-7089-01A-11D-2012-08	1313510	38241015	42954195	143	39867											
KRT39	390792	broad.mit.edu	37	chr17	39122956	39122956	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctggtcccagggaattctGagaacgtggccagctggttg	7	9	14	11	1	1	1	0	1	1	1	2	3	2	2	3	4	2	2	3	4	2	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:39122956G>A	uc002hvo.1	-	1	189	c.153C>T	c.(151-153)CTC>CTT	p.L51L	KRT39_uc010wfm.1_5'UTR	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	51	Head.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				AGGGAATTCTGAGAACGTGGC	0.498													41	243					0	0	0	0	A	39122956	A	A	39122956	2	1	216	1	0	0	0	0	0	0	0	1	8515	1277	45	2		2	KRT39	17	39122956	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	881941	39122956	42072254	144	39868											
ITGA3	3675	broad.mit.edu	37	chr17	48148225	48148225	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggaaacagctacatgattCagcgcaaggagtgggactta	15	7	12	7	1	1	1	1	1	0	0	1	4	1	4	0	3	4	2	0	3	5	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:48148225C>T	uc010dbl.2	+	5	1146	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	ITGA3_uc010dbm.2_Nonsense_Mutation_p.Q228*	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	228	FG-GAP 3.|Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						CTACATGATTCAGCGCAAGGA	0.502													37	229					0	0	0	0	T	48148225	T	T	48148225	4	4	216	1	0	0	0	0	0	1	0	0	7916	827	29	2	700	2	ITGA3	17	48148225	Nonsense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	9025269	48148225	33046985	145	39869											
BZRAP1	9256	broad.mit.edu	37	chr17	56397485	56397485	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctacctgcatggaatccaaGgtagactgttgcaggaaagg	12	8	13	8	0	0	1	0	0	0	1	1	3	1	3	2	4	3	5	2	4	5	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:56397485G>T	uc002ivx.3	-	12	2350	c.1479C>A	c.(1477-1479)ACC>ACA	p.T493T	BZRAP1_uc010dcs.2_Silent_p.T433T|BZRAP1_uc010wnt.1_Silent_p.T493T	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	493						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGGAATCCAAGGTAGACTGTT	0.592													9	47					3.09899e-07	6.12453e-07	1	0	T	56397485	T	T	56397485	2	4	216	1	0	0	0	0	0	0	0	1	1582	987	35	4		4	BZRAP1	17	56397485	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	8249260	56397485	24797725	146	39870											
CCDC47	57003	broad.mit.edu	37	chr17	61838631	61838631	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacagcacactcgaccagAacaccacaggttatagatgt	14	7	7	13	1	1	2	1	0	0	2	2	3	1	2	2	1	2	2	2	1	3	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:61838631A>C	uc002jbs.3	-	5	964	c.628T>G	c.(628-630)TCT>GCT	p.S210A	CCDC47_uc010ddx.2_Missense_Mutation_p.S210A|CCDC47_uc002jbt.2_Missense_Mutation_p.S210A	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	210						integral to membrane	protein binding				0						ACTCGACCAGAACACCACAGG	0.433													17	96					0	0	0	0	C	61838631	C	C	61838631	3	2	216	1	0	0	0	0	1	0	0	0	2831	246	9	5	859	5	CCDC47	17	61838631	Missense_Mutation	SNP	A	TCGA-CV-7089-01A-11D-2012-08	5441146	61838631	19356579	147	39871											
CACNG5	27091	broad.mit.edu	37	chr17	64876761	64876761	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacaacatcggacacatccGtccccaccggacgatactgg	12	5	9	15	4	0	0	0	0	0	0	3	4	2	2	4	3	3	0	4	3	3	1	rs145214481		TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:64876761G>A	uc010wqi.1	+	4	608	c.371G>A	c.(370-372)CGT>CAT	p.R124H	CACNG5_uc002jfr.2_Missense_Mutation_p.R124H|CACNG5_uc010wqj.1_Missense_Mutation_p.R124H	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	124					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			GGACACATCCGTCCCCACCGG	0.453													20	129					0	0	0	0	A	64876761	A	A	64876761	3	1	216	1	0	0	0	0	1	0	0	0	2572	1145	40	1	381	1	CACNG5	17	64876761	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	3038130	64876761	16318449	148	39872											
RAC3	5881	broad.mit.edu	37	chr17	79991361	79991361	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccccacacgcccatcctcCtggtgggcaccaagctggac	7	5	10	19	1	0	0	0	0	0	0	2	1	2	1	6	3	1	2	6	3	1	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:79991361C>T	uc002kdf.2	+	5	440	c.334C>T	c.(334-336)CTG>TTG	p.L112L		NM_005052	NP_005043	P60763	RAC3_HUMAN	ras-related C3 botulinum toxin substrate 3 (rho	112					actin cytoskeleton organization|cell projection assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endomembrane system|filamentous actin|growth cone|lamellipodium|neuronal cell body|plasma membrane	GTP binding|GTPase activity|protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GCCCATCCTCCTGGTGGGCAC	0.672													4	47					0	0	0	0	T	79991361	T	T	79991361	2	4	216	1	0	0	0	0	0	0	0	1	13041	680	24	4		4	RAC3	17	79991361	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	15114600	79991361	1203849	149	39873											
RAC3	5881	broad.mit.edu	37	chr17	79991599	79991599	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgaaatacctggagtgctCagccctgacccagcggggcc	8	7	13	13	1	1	2	1	2	0	0	1	3	1	3	4	3	4	1	4	3	2	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr17:79991599C>G	uc002kdf.2	+	6	579	c.473C>G	c.(472-474)TCA>TGA	p.S158*		NM_005052	NP_005043	P60763	RAC3_HUMAN	ras-related C3 botulinum toxin substrate 3 (rho	158					actin cytoskeleton organization|cell projection assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endomembrane system|filamentous actin|growth cone|lamellipodium|neuronal cell body|plasma membrane	GTP binding|GTPase activity|protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CTGGAGTGCTCAGCCCTGACC	0.657													9	43					0	0	0	0	G	79991599	G	G	79991599	4	3	216	1	0	0	0	0	0	1	0	0	13041	838	29	2	495	2	RAC3	17	79991599	Nonsense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	238	79991599	1203611	150	39874											
CTAGE1	64693	broad.mit.edu	37	chr18	19995815	19995815	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagccagggccagttgcttCattttcagcggggagagatg	10	9	14	8	1	2	1	2	0	0	1	2	3	2	2	2	3	3	2	2	3	1	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr18:19995815C>T	uc002ktv.1	-	1	2064	c.1960G>A	c.(1960-1962)GAA>AAA	p.E654K		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	654						integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					CCAGTTGCTTCATTTTCAGCG	0.453													24	244					0	0	0	0	T	19995815	T	T	19995815	3	4	216	1	0	0	0	0	1	0	0	0	4009	835	29	2	281	2	CTAGE1	18	19995815	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08		19995815	58081433	151	39875											
AP3D1	8943	broad.mit.edu	37	chr19	2110168	2110168	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacagggtccccttgagcttCtgcgccatgacgatgctctg	6	10	12	13	2	2	2	0	2	2	0	3	4	3	2	3	1	3	2	3	1	0	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:2110168C>T	uc002luz.2	-	26	3268	c.3045G>A	c.(3043-3045)CAG>CAA	p.Q1015Q	AP3D1_uc010dsv.2_Silent_p.Q105Q|AP3D1_uc002luy.2_Silent_p.Q974Q|AP3D1_uc002lva.2_Silent_p.Q1077Q	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	1015					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTTGAGCTTCTGCGCCATGA	0.642													9	39					0	0	0	0	T	2110168	T	T	2110168	2	4	216	1	0	0	0	0	0	0	0	1	746	912	32	2		2	AP3D1	19	2110168	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08		2110168	57018815	152	39876											
ZNF77	58492	broad.mit.edu	37	chr19	2934164	2934164	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttacactgacagggtttctCtccagtgtgcgtcctcacgt	6	14	9	12	2	2	1	1	1	1	0	5	1	4	1	2	1	2	1	2	1	1	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:2934164C>G	uc002lws.3	-	4	1092	c.961G>C	c.(961-963)GAG>CAG	p.E321Q		NM_021217	NP_067040	Q15935	ZNF77_HUMAN	zinc finger protein 77	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGGTTTCTCTCCAGTGTGC	0.458													9	91					0	0	0	0	G	2934164	G	G	2934164	3	3	216	1	0	0	0	0	1	0	0	0	18209	922	32	2	680	2	ZNF77	19	2934164	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	823996	2934164	56194819	153	39877											
SAFB	6294	broad.mit.edu	37	chr19	5667066	5667066	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgatgtccagcattacccaGaacgccatggaggaccagag	12	6	12	11	1	0	3	0	1	0	2	1	5	1	5	4	2	3	1	4	2	2	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:5667066G>A	uc002mcf.2	+	18	2397	c.2344G>A	c.(2344-2346)GAA>AAA	p.E782K	SAFB_uc002mcg.2_Missense_Mutation_p.E782K|SAFB_uc002mce.3_Missense_Mutation_p.E781K|SAFB_uc010xir.1_Missense_Mutation_p.E781K|SAFB_uc010xis.1_Missense_Mutation_p.E713K|SAFB_uc010xit.1_Missense_Mutation_p.E624K|SAFB_uc010xiu.1_Missense_Mutation_p.E581K	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	782	Interaction with SAFB2.|Interaction with POLR2A.|Arg-rich.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		GCATTACCCAGAACGCCATGG	0.607													14	113					0	0	0	0	A	5667066	A	A	5667066	3	1	216	1	0	0	0	0	1	0	0	0	13871	943	33	2	2414	2	SAFB	19	5667066	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	2732902	5667066	53461917	154	39878											
CCDC151	115948	broad.mit.edu	37	chr19	11532486	11532486	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggatccagctcctttcccgcGaagcggccgtcctcctgcgg	4	8	12	17	5	0	0	0	0	0	0	5	2	5	1	6	3	3	1	6	3	1	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:11532486G>A	uc002mrs.2	-	11	1592	c.1449C>T	c.(1447-1449)TTC>TTT	p.F483F	CCDC151_uc002mrr.2_Silent_p.F418F|CCDC151_uc010dxz.2_Silent_p.F423F|RGL3_uc002mrn.2_5'Flank|RGL3_uc002mrm.2_5'Flank|RGL3_uc002mro.2_5'Flank|RGL3_uc002mrp.2_5'Flank|RGL3_uc002mrq.2_5'Flank	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	483										ovary(1)	1						CCTTTCCCGCGAAGCGGCCGT	0.662													11	65					0	0	0	0	A	11532486	A	A	11532486	2	1	216	1	0	0	0	0	0	0	0	1	2798	1049	37	1		1	CCDC151	19	11532486	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	5865420	11532486	47596497	155	39879											
MAST1	22983	broad.mit.edu	37	chr19	12951862	12951862	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caacacccccgcccacttctCgtttgcctcctcccgaaggt	6	9	6	20	3	1	0	0	0	1	0	4	1	3	0	6	1	2	1	6	1	2	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:12951862C>G	uc002mvm.2	+	3	358	c.230C>G	c.(229-231)TCG>TGG	p.S77W	MAST1_uc002mvk.2_Missense_Mutation_p.S73W|MAST1_uc002mvl.2_Missense_Mutation_p.S77W	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	77					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						GCCCACTTCTCGTTTGCCTCC	0.632													17	77					0	0	0	0	G	12951862	G	G	12951862	3	3	216	1	0	0	0	0	1	0	0	0	9377	893	31	3	240	3	MAST1	19	12951862	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	1419376	12951862	46177121	156	39880											
GADD45GIP1	90480	broad.mit.edu	37	chr19	13065144	13065144	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgcttgcgctccttcttctCtaggtcctggagcagctcct	3	13	10	15	2	2	0	0	0	2	0	6	1	5	1	3	2	3	4	3	2	1	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:13065144C>G	uc002mwb.2	-	2	571	c.547G>C	c.(547-549)GAG>CAG	p.E183Q		NM_052850	NP_443082	Q8TAE8	G45IP_HUMAN	growth arrest and DNA-damage-inducible, gamma	183	Potential.				cell cycle|interspecies interaction between organisms	nucleus	protein binding			ovary(1)|skin(1)	2						TCCTTCTTCTCTAGGTCCTGG	0.627													17	130					0	0	0	0	G	13065144	G	G	13065144	3	3	216	1	0	0	0	0	1	0	0	0	6218	922	32	2	125	2	GADD45GIP1	19	13065144	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	113282	13065144	46063839	157	39881											
CYP4F11	57834	broad.mit.edu	37	chr19	16025612	16025612	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgggagcacaaagtcctgCgtgcaacatcgggagatgac	11	7	13	10	2	1	2	0	1	1	1	3	4	2	3	1	2	4	2	1	2	2	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:16025612C>T	uc002nbu.2	-	10	1245	c.1209G>A	c.(1207-1209)ACG>ACA	p.T403T	CYP4F11_uc010eab.1_Silent_p.T403T|CYP4F11_uc002nbt.2_Silent_p.T403T	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	403					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						CAAAGTCCTGCGTGCAACATC	0.632													19	106					0	0	0	0	T	16025612	T	T	16025612	2	4	216	1	0	0	0	0	0	0	0	1	4203	755	27	1		1	CYP4F11	19	16025612	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	2960468	16025612	43103371	158	39882											
GATAD2A	54815	broad.mit.edu	37	chr19	19603492	19603492	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaaaagttgcggcagagtCaaatacaaaaggaagccacc	18	5	10	8	1	1	2	1	1	0	1	1	3	1	3	2	2	3	2	2	2	7	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:19603492C>G	uc010xqt.1	+	4	817	c.505C>G	c.(505-507)CAA>GAA	p.Q169E	GATAD2A_uc010xqu.1_Intron|GATAD2A_uc010xqv.1_Missense_Mutation_p.Q188E|GATAD2A_uc010xqw.1_Missense_Mutation_p.Q26E	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	169	Potential.				DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCGGCAGAGTCAAATACAAAA	0.517													5	54					0	0	0	0	G	19603492	G	G	19603492	3	3	216	1	0	0	0	0	1	0	0	0	6295	827	29	2	515	2	GATAD2A	19	19603492	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	3577880	19603492	39525491	159	39883											
ZNF91	7644	broad.mit.edu	37	chr19	23544684	23544684	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatgagttatcttatgattaGcaagggttgaggaattgcta	12	15	11	3	0	1	3	0	3	1	0	1	4	1	4	0	2	2	4	0	2	7	7			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:23544684G>T	uc002nre.2	-	4	1210	c.1097C>A	c.(1096-1098)GCT>GAT	p.A366D	ZNF91_uc010xrj.1_Missense_Mutation_p.A334D	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	366	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				CTTATGATTAGCAAGGGTTGA	0.348													11	42					6.40141e-05	0.000123583	1	0	T	23544684	T	T	23544684	3	4	216	1	0	0	0	0	1	0	0	0	18267	971	34	4	2482	4	ZNF91	19	23544684	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	3941192	23544684	35584299	160	39884											
ZNF568	374900	broad.mit.edu	37	chr19	37440746	37440746	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtaatcagtgtggacaagacTtcagtcataaatttgacctc	13	12	8	8	0	3	2	3	1	0	1	4	3	3	3	1	1	0	1	1	1	4	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:37440746T>G	uc002ofc.2	+	7	1206	c.691T>G	c.(691-693)TTC>GTC	p.F231V	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.F155V|ZNF568_uc010efe.2_Missense_Mutation_p.F155V|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	231	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGGACAAGACTTCAGTCATAA	0.388													10	57					0	0	0	0	G	37440746	G	G	37440746	3	3	216	1	0	0	0	0	1	0	0	0	18066	1609	56	5	709	5	ZNF568	19	37440746	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	13896062	37440746	21688237	161	39885											
SPINT2	10653	broad.mit.edu	37	chr19	38781203	38781203	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagaatcctcccctgcccCttggctcaaagggtaagtgg	9	8	12	12	0	1	1	1	0	0	1	3	2	3	1	5	4	1	2	5	4	3	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:38781203C>G	uc002ohr.1	+	6	911	c.580C>G	c.(580-582)CTT>GTT	p.L194V	SPINT2_uc002ohs.1_Missense_Mutation_p.L137V	NM_021102	NP_066925	O43291	SPIT2_HUMAN	serine protease inhibitor, Kunitz type, 2	194	Extracellular (Potential).				cellular component movement	cytoplasm|extracellular region|integral to membrane|soluble fraction	serine-type endopeptidase inhibitor activity				0	all_cancers(60;6.83e-07)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TCCCCTGCCCCTTGGCTCAAA	0.612													4	25					0	0	0	0	G	38781203	G	G	38781203	3	3	216	1	0	0	0	0	1	0	0	0	15135	681	24	4	602	4	SPINT2	19	38781203	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	1340457	38781203	20347780	162	39886											
FCGBP	8857	broad.mit.edu	37	chr19	40364331	40364331	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcatcgcagacacagccttCacggcaggccgactcacagc	11	4	10	16	3	2	1	2	0	0	1	3	2	2	1	2	2	3	3	2	2	0	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:40364331C>T	uc002omp.3	-	31	14319	c.14311G>A	c.(14311-14313)GAA>AAA	p.E4771K		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4771	TIL 11.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACACAGCCTTCACGGCAGGCC	0.652													10	71					0	0	0	0	T	40364331	T	T	40364331	3	4	216	1	0	0	0	0	1	0	0	0	5810	835	29	2	1930	2	FCGBP	19	40364331	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	1583128	40364331	18764652	163	39887											
FCGBP	8857	broad.mit.edu	37	chr19	40366539	40366539	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgtgcaggagcgagtccagCtggaaaggcagagccacgaa	12	3	16	10	3	0	1	0	0	0	1	1	5	1	3	2	3	4	3	2	3	2	0			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:40366539C>T	uc002omp.3	-	30	13703	c.13695G>A	c.(13693-13695)CAG>CAA	p.Q4565Q		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4565	VWFD 11.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCGAGTCCAGCTGGAAAGGCA	0.602													10	60					0	0	0	0	T	40366539	T	T	40366539	2	4	216	1	0	0	0	0	0	0	0	1	5810	796	28	4		4	FCGBP	19	40366539	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	2208	40366539	18762444	164	39888											
PLAUR	5329	broad.mit.edu	37	chr19	44160641	44160641	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggggctcaccttcttcaccTtcctggatccagtgggtcac	5	12	10	14	0	4	0	3	0	1	0	6	1	6	1	4	4	0	1	4	4	0	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:44160641T>C	uc002oxf.1	-	4	692	c.462A>G	c.(460-462)GAA>GAG	p.E154E	PLAUR_uc002oxd.1_Silent_p.E154E|PLAUR_uc002oxe.1_Silent_p.E149E|PLAUR_uc002oxg.1_Silent_p.E154E	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	154	UPAR/Ly6 2.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	CTTCTTCACCTTCCTGGATCC	0.493													23	119					0	0	0	0	C	44160641	C	C	44160641	2	2	216	1	0	0	0	0	0	0	0	1	12078	1606	56	5		5	PLAUR	19	44160641	Silent	SNP	T	TCGA-CV-7089-01A-11D-2012-08	3794102	44160641	14968342	165	39889											
ZNF610	162963	broad.mit.edu	37	chr19	52852486	52852486	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtcagggatggctcttcctCaggtaaagtgatattctcgg	9	12	12	8	1	4	1	2	1	2	0	6	2	5	2	1	4	0	2	1	4	3	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:52852486C>G	uc002pyx.3	+	3	467	c.61C>G	c.(61-63)CAG>GAG	p.Q21E	ZNF610_uc002pyy.3_Missense_Mutation_p.Q21E|ZNF610_uc002pyz.3_Missense_Mutation_p.Q21E|ZNF610_uc002pza.2_Missense_Mutation_p.Q21E	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GGCTCTTCCTCAGGTAAAGTG	0.448													6	34					0	0	0	0	G	52852486	G	G	52852486	3	3	216	1	0	0	0	0	1	0	0	0	18103	827	29	2	63	2	ZNF610	19	52852486	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	8691845	52852486	6276497	166	39890											
NCR1	9437	broad.mit.edu	37	chr19	55421380	55421380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttatctccttttccaggcGacattgagaacaccagcctt	9	13	6	13	1	1	1	0	1	1	1	3	3	2	1	4	1	2	0	4	1	2	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:55421380G>A	uc002qib.2	+	5	675	c.637G>A	c.(637-639)GAC>AAC	p.D213N	NCR1_uc002qic.2_Missense_Mutation_p.D213N|NCR1_uc002qie.2_Missense_Mutation_p.D213N|NCR1_uc002qid.2_Missense_Mutation_p.D118N|NCR1_uc002qif.2_Missense_Mutation_p.D118N|NCR1_uc010esj.2_Missense_Mutation_p.D106N	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	213	Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		TTTTCCAGGCGACATTGAGAA	0.398													23	169					0	0	0	0	A	55421380	A	A	55421380	3	1	216	1	0	0	0	0	1	0	0	0	10291	1058	37	1	655	1	NCR1	19	55421380	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	2568894	55421380	3707603	167	39891											
EPN1	29924	broad.mit.edu	37	chr19	56204351	56204351	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacacggagcccgacgagttCtctgactttgaccgactccg	8	8	11	14	5	1	2	0	2	1	0	3	7	2	3	3	1	1	1	3	1	0	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr19:56204351C>A	uc002qlw.2	+	9	1554	c.1212C>A	c.(1210-1212)TTC>TTA	p.F404L	EPN1_uc002qlv.2_Missense_Mutation_p.F378L|EPN1_uc010etd.2_Missense_Mutation_p.F403L|EPN1_uc002qlx.2_Missense_Mutation_p.F490L	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	404	[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif.|Ala/Gly/Pro-rich.			F->A: Reduces interaction with AP2B1.	endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		CCGACGAGTTCTCTGACTTTG	0.701													13	117					4.3838e-07	8.58237e-07	1	0	A	56204351	A	A	56204351	3	1	216	1	0	0	0	0	1	0	0	0	5209	912	32	2	1583	2	EPN1	19	56204351	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	782971	56204351	2924632	168	39892											
PSMF1	9491	broad.mit.edu	37	chr20	1115772	1115772	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcttcctgcaggacctacaAgaacagtgaggagcttcggt	10	9	12	10	1	0	2	0	1	0	1	2	4	1	4	2	3	5	3	2	3	3	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr20:1115772A>G	uc002wel.3	+	5	542	c.374A>G	c.(373-375)AAG>AGG	p.K125R	PSMF1_uc010zpo.1_Missense_Mutation_p.K37R|PSMF1_uc002wem.3_Missense_Mutation_p.K125R|PSMF1_uc010zpp.1_Intron|PSMF1_uc002wen.3_Missense_Mutation_p.K125R|PSMF1_uc002wep.3_Missense_Mutation_p.K76R	NM_178578	NP_848693	Q92530	PSMF1_HUMAN	proteasome inhibitor subunit 1	125					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding				0						AGGACCTACAAGAACAGTGAG	0.552													7	55					0	0	0	0	G	1115772	G	G	1115772	3	3	216	1	0	0	0	0	1	0	0	0	12772	72	3	5	388	5	PSMF1	20	1115772	Missense_Mutation	SNP	A	TCGA-CV-7089-01A-11D-2012-08		1115772	61909748	169	39893											
ASXL1	171023	broad.mit.edu	37	chr20	31022294	31022294	+	Frame_Shift_Del	DEL	A	-	-																															ggtcagcccacttaccagatAtgcccccggatcatccccac																										TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr20:31022294delA	uc002wxs.2	+	12	2205	c.1779delA	c.(1777-1779)ATAfs	p.I593fs	ASXL1_uc010geb.2_Frame_Shift_Del_p.I484fs	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	593					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.Q592fs*5(1)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CTTACCAGATATGCCCCCGGA	0.532			F|N|Mis		MDS|CMML								---	---	---								-	31022294	-	-	31022294	7	5	216	1	0	1	0	1	0	0	0	0	1068	439	16	0	1835	0	ASXL1	20	31022294	Frame_Shift_Del	DEL	A	TCGA-CV-7089-01A-11D-2012-08	29906522	31022294	32003226	170	39894											
BPIL1	80341	broad.mit.edu	37	chr20	31608358	31608358	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctctttcagggatgtccagCtcacggtggcctcctccaac	6	11	9	15	1	3	0	2	0	1	0	7	1	6	1	4	3	2	1	4	3	1	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr20:31608358C>A	uc002wyj.2	+	13	1353	c.1159C>A	c.(1159-1161)CTC>ATC	p.L387I		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	387						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						GGATGTCCAGCTCACGGTGGC	0.617													9	93					0.000673444	0.00128231	1	0	A	31608358	A	A	31608358	3	1	216	1	0	0	0	0	1	0	0	0	1496	797	28	4	1205	4	BPIL1	20	31608358	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	586064	31608358	31417162	171	39895											
PPP1R16B	26051	broad.mit.edu	37	chr20	37524339	37524339	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccacatcaacctggtgaaGatcctcgttcagtagtacgt	10	10	10	11	2	2	2	2	1	0	1	4	2	3	2	3	2	2	3	3	2	4	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr20:37524339G>C	uc002xje.2	+	4	642	c.453G>C	c.(451-453)AAG>AAC	p.K151N	PPP1R16B_uc010ggc.2_Missense_Mutation_p.K151N	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	151	ANK 2.				regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				ACCTGGTGAAGATCCTCGTTC	0.498													5	25					0	0	0	0	C	37524339	C	C	37524339	3	2	216	1	0	0	0	0	1	0	0	0	12426	933	33	2	463	2	PPP1R16B	20	37524339	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	5915981	37524339	25501181	172	39896											
ZNF512B	57473	broad.mit.edu	37	chr20	62597525	62597525	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actgttcctccctgtggcacGaggtgctttgttctccgacc	4	13	10	14	2	1	0	0	0	1	0	4	2	3	0	4	2	1	4	4	2	0	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr20:62597525G>A	uc002yhl.1	-	5	1057	c.1003C>T	c.(1003-1005)CGT>TGT	p.R335C		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CCTGTGGCACGAGGTGCTTTG	0.582													9	62					0	0	0	0	A	62597525	A	A	62597525	3	1	216	1	0	0	0	0	1	0	0	0	18024	1058	37	1	1727	1	ZNF512B	20	62597525	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	25073186	62597525	427995	173	39897											
CHEK2	11200	broad.mit.edu	37	chr22	29121060	29121060	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtatttacaaaggttccaTtgccactgtgatcttctatg	9	16	7	9	0	2	1	0	1	2	0	3	1	3	1	2	1	2	2	2	1	4	7			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:29121060T>C	uc003adu.1	-	4	569	c.497A>G	c.(496-498)AAT>AGT	p.N166S	CHEK2_uc003ads.1_Intron|CHEK2_uc010gvh.1_Intron|CHEK2_uc010gvi.1_Missense_Mutation_p.N166S|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.N209S|CHEK2_uc003adv.1_Missense_Mutation_p.N166S|CHEK2_uc003adw.1_Missense_Mutation_p.N166S|CHEK2_uc003adx.1_5'UTR|CHEK2_uc003ady.1_Missense_Mutation_p.N166S|CHEK2_uc003adz.1_Intron	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	166	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						AAAGGTTCCATTGCCACTGTG	0.353			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				6	76					0	0	0	0	C	29121060	C	C	29121060	3	2	216	1	0	0	0	0	1	0	0	0	3350	1493	52	5	1182	5	CHEK2	22	29121060	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08		29121060	22183506	174	39898											
PKDREJ	10343	broad.mit.edu	37	chr22	46652485	46652485	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acaaggtaaaccattttcttCccgttgatgtttctggtctt	8	17	7	9	1	3	1	0	1	3	0	4	1	4	1	2	2	1	3	2	2	3	7			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46652485C>T	uc003bhh.2	-	1	6735	c.6735G>A	c.(6733-6735)GGG>GGA	p.G2245G		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	2245	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CCATTTTCTTCCCGTTGATGT	0.473													10	94					0	0	0	0	T	46652485	T	T	46652485	2	4	216	1	0	0	0	0	0	0	0	1	12025	842	30	2		2	PKDREJ	22	46652485	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	17531425	46652485	4652081	175	39899			1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46653078	46653078	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaattatcctcataatgtGatctacctgagaaactgcat	15	12	5	9	0	2	2	1	2	1	1	3	3	3	2	2	0	3	1	2	0	6	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46653078G>C	uc003bhh.2	-	1	6142	c.6142C>G	c.(6142-6144)CAC>GAC	p.H2048D		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	2048	Helical; (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CTCATAATGTGATCTACCTGA	0.438													6	59					0	0	0	0	C	46653078	C	C	46653078	3	2	216	1	0	0	0	0	1	0	0	0	12025	1290	45	2	623	2	PKDREJ	22	46653078	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	593	46653078	4651488	176	39900			1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46653873	46653873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggattttagacgagctttCaggaagaaatgttggattca	14	12	11	4	1	2	2	2	0	0	2	2	6	2	5	0	3	1	2	0	3	4	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46653873C>T	uc003bhh.2	-	1	5347	c.5347G>A	c.(5347-5349)GAA>AAA	p.E1783K		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1783	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GACGAGCTTTCAGGAAGAAAT	0.423													19	172					0	0	0	0	T	46653873	T	T	46653873	3	4	216	1	0	0	0	0	1	0	0	0	12025	835	29	2	1418	2	PKDREJ	22	46653873	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	795	46653873	4650693	177	39901			1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46653935	46653935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagcacgctgtttagccatCtatagatgtcttccagctta	10	13	7	11	1	2	1	0	0	2	1	3	1	3	1	2	0	3	4	2	0	4	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46653935C>T	uc003bhh.2	-	1	5285	c.5285G>A	c.(5284-5286)AGA>AAA	p.R1762K		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1762	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GTTTAGCCATCTATAGATGTC	0.423													17	115					0	0	0	0	T	46653935	T	T	46653935	3	4	216	1	0	0	0	0	1	0	0	0	12025	913	32	2	1480	2	PKDREJ	22	46653935	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	62	46653935	4650631	178	39902			1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46654045	46654045	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtagtaagacgataaggatCaacagaagggctagaaagat	18	6	12	5	2	1	4	1	0	0	4	1	6	1	5	0	2	1	3	0	2	7	4			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46654045C>T	uc003bhh.2	-	1	5175	c.5175G>A	c.(5173-5175)TTG>TTA	p.L1725L		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1725	Helical; (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CGATAAGGATCAACAGAAGGG	0.383													8	52					0	0	0	0	T	46654045	T	T	46654045	2	4	216	1	0	0	0	0	0	0	0	1	12025	825	29	2		2	PKDREJ	22	46654045	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	110	46654045	4650521	179	39903			1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46654120	46654120	+	Silent	SNP	C	T	T																															gctcttctcttgatcctcttCtttcttttgaatattctgat																										TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46654120C>T	uc003bhh.2	-	1	5100	c.5100G>A	c.(5098-5100)AAG>AAA	p.K1700K		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1700	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TGATCCTCTTCTTTCTTTTGA	0.418													7	82					0	0	0	0	T	46654120	T	T	46654120	2	4	216	1	0	0	0	0	0	0	0	1	12025	912	32	2		2	PKDREJ	22	46654120	Silent	SNP	C	TCGA-CV-7089-01A-11D-2012-08	75	46654120	4650446	180	39904	81	2	1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46654124	46654124	+	Missense_Mutation	SNP	C	T	T																															ttctcttgatcctcttctttCttttgaatattctgatttca																										TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46654124C>T	uc003bhh.2	-	1	5096	c.5096G>A	c.(5095-5097)AGA>AAA	p.R1699K		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1699	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CCTCTTCTTTCTTTTGAATAT	0.418													7	87					0	0	0	0	T	46654124	T	T	46654124	3	4	216	1	0	0	0	0	1	0	0	0	12025	913	32	2	1669	2	PKDREJ	22	46654124	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	4	46654124	4650442	181	39905	81	2	1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46654251	46654251	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattccatccaacctgatctCagtatatttatacttggttg	10	16	5	10	0	1	1	1	1	1	0	4	1	3	1	3	1	2	2	3	1	5	8			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46654251C>T	uc003bhh.2	-	1	4969	c.4969G>A	c.(4969-4971)GAG>AAG	p.E1657K		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1657	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AACCTGATCTCAGTATATTTA	0.438													10	80					0	0	0	0	T	46654251	T	T	46654251	3	4	216	1	0	0	0	0	1	0	0	0	12025	835	29	2	1796	2	PKDREJ	22	46654251	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	127	46654251	4650315	182	39906			1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46654407	46654407	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagccattctattgacttgtCatagccgtaagtcagtccat	10	13	8	10	1	3	1	2	1	1	0	4	2	4	1	3	0	2	1	3	0	3	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46654407C>G	uc003bhh.2	-	1	4813	c.4813G>C	c.(4813-4815)GAC>CAC	p.D1605H		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1605	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATTGACTTGTCATAGCCGTAA	0.393													6	53					0	0	0	0	G	46654407	G	G	46654407	3	3	216	1	0	0	0	0	1	0	0	0	12025	826	29	2	1952	2	PKDREJ	22	46654407	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	156	46654407	4650159	183	39907			1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46654584	46654584	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaatggacatcctgatcatCttctatgttgttattggaat	10	16	9	6	0	3	1	1	1	2	0	4	4	4	4	1	3	0	2	1	3	4	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46654584C>T	uc003bhh.2	-	1	4636	c.4636G>A	c.(4636-4638)GAT>AAT	p.D1546N		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1546	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TCCTGATCATCTTCTATGTTG	0.483													33	233					0	0	0	0	T	46654584	T	T	46654584	3	4	216	1	0	0	0	0	1	0	0	0	12025	913	32	2	2129	2	PKDREJ	22	46654584	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	177	46654584	4649982	184	39908			1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46654926	46654926	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattgtaattaagacactttCaattcctatcatcattgatc	13	16	4	8	0	3	2	3	1	0	1	5	3	4	2	1	0	0	1	1	0	4	7			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46654926C>T	uc003bhh.2	-	1	4294	c.4294G>A	c.(4294-4296)GAA>AAA	p.E1432K		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1432	Helical; (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AAGACACTTTCAATTCCTATC	0.348													8	61					0	0	0	0	T	46654926	T	T	46654926	3	4	216	1	0	0	0	0	1	0	0	0	12025	835	29	2	2471	2	PKDREJ	22	46654926	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	342	46654926	4649640	185	39909			1	62		12	11	2464	N	G_C	2.047989e-25
PKDREJ	10343	broad.mit.edu	37	chr22	46654948	46654948	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcctatcatcattgatctCatgtatttcctctctcttga	8	19	3	11	0	5	2	3	2	3	0	9	2	7	2	2	0	0	1	2	0	2	6			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:46654948C>T	uc003bhh.2	-	1	4272	c.4272G>A	c.(4270-4272)ATG>ATA	p.M1424I		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1424	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TCATTGATCTCATGTATTTCC	0.348													8	60					0	0	0	0	T	46654948	T	T	46654948	3	4	216	1	0	0	0	0	1	0	0	0	12025	826	29	2	2493	2	PKDREJ	22	46654948	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	22	46654948	4649618	186	39910			1	62		12	11	2464	N	G_C	2.047989e-25
CPT1B	1375	broad.mit.edu	37	chr22	51010730	51010730	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgagagtgaaggatttgtCaaaccacctgcaggaagagt	15	8	12	6	0	1	3	1	2	0	2	1	6	1	5	2	2	2	1	2	2	4	1			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chr22:51010730C>G	uc003bmk.3	-	11	1522	c.1360G>C	c.(1360-1362)GAC>CAC	p.D454H	CPT1B_uc003bml.2_Missense_Mutation_p.D454H|CPT1B_uc003bmm.2_Missense_Mutation_p.D454H|CPT1B_uc003bmo.2_Missense_Mutation_p.D454H|CPT1B_uc011asa.1_Missense_Mutation_p.D420H|CPT1B_uc003bmn.2_Missense_Mutation_p.D454H|CPT1B_uc011asb.1_Missense_Mutation_p.D373H|CHKB-CPT1B_uc003bmp.2_Missense_Mutation_p.D251H|uc003bmr.1_RNA	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	454	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		AAGGATTTGTCAAACCACCTG	0.443													6	38					0	0	0	0	G	51010730	G	G	51010730	3	3	216	1	0	0	0	0	1	0	0	0	3847	826	29	2	990	2	CPT1B	22	51010730	Missense_Mutation	SNP	C	TCGA-CV-7089-01A-11D-2012-08	4355782	51010730	293836	187	39911											
ARSD	414	broad.mit.edu	37	chrX	2825395	2825395	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccacggcttccacaggaTgttgctcatggaaaactgct	10	9	10	12	1	1	0	1	0	0	0	2	2	2	2	2	3	4	4	2	3	2	2			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chrX:2825395T>C	uc004cqy.2	-	10	1775	c.1699A>G	c.(1699-1701)ATC>GTC	p.I567V	ARSD_uc004cqz.1_RNA	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	567						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTCCACAGGATGTTGCTCATG	0.617													6	27					0	0	0	0	C	2825395	C	C	2825395	3	2	216	1	0	0	0	0	1	0	0	0	991	1464	51	5	86	5	ARSD	23	2825395	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08		2825395	152445165	188	39912											
BEND2	139105	broad.mit.edu	37	chrX	18192280	18192280	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcattggctgaaacatccaAgaacagccttcaccaccatc	13	9	5	14	0	2	2	2	1	0	1	4	2	3	2	4	1	3	1	4	1	3	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chrX:18192280A>C	uc004cyj.3	-	12	2005	c.1851T>G	c.(1849-1851)TCT>TCG	p.S617S	BEND2_uc010nfb.2_Silent_p.S526S	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	617										ovary(3)|kidney(1)|central_nervous_system(1)	5						GAAACATCCAAGAACAGCCTT	0.438													25	58					0	0	0	0	C	18192280	C	C	18192280	2	2	216	1	0	0	0	0	0	0	0	1	1400	59	3	5		5	BEND2	23	18192280	Silent	SNP	A	TCGA-CV-7089-01A-11D-2012-08	15366885	18192280	137078280	189	39913											
SH3KBP1	30011	broad.mit.edu	37	chrX	19702122	19702122	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagtcacccccatcactcTcggagcctgtggtttccctt	5	13	8	15	1	3	1	2	1	1	0	5	2	4	2	4	2	1	1	4	2	0	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chrX:19702122T>A	uc004czm.2	-	6	861	c.545A>T	c.(544-546)GAG>GTG	p.E182V	SH3KBP1_uc004czl.2_Missense_Mutation_p.E145V	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	182					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						CCCATCACTCTCGGAGCCTGT	0.537													8	38					0	0	0	0	A	19702122	A	A	19702122	3	1	216	1	0	0	0	0	1	0	0	0	14320	1551	54	5	1520	5	SH3KBP1	23	19702122	Missense_Mutation	SNP	T	TCGA-CV-7089-01A-11D-2012-08	1509842	19702122	135568438	190	39914											
HUWE1	10075	broad.mit.edu	37	chrX	53617986	53617986	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aactcctcccatgattggagGagggtgggttaaaaggtact	11	10	13	7	0	0	1	0	1	0	0	2	3	2	3	2	5	2	2	2	5	4	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chrX:53617986G>A	uc004dsp.2	-	34	4471	c.4069C>T	c.(4069-4071)CCT>TCT	p.P1357S	HUWE1_uc004dsn.2_Missense_Mutation_p.P182S	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1357					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						ATGATTGGAGGAGGGTGGGTT	0.488													4	20					0	0	0	0	A	53617986	A	A	53617986	3	1	216	1	0	0	0	0	1	0	0	0	7500	1174	41	2	9259	2	HUWE1	23	53617986	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	33915864	53617986	101652574	191	39915											
HUWE1	10075	broad.mit.edu	37	chrX	53619384	53619384	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagttgttgctggttgacttGaggttcccggcgggagccac	5	11	15	10	2	0	2	0	2	0	0	1	3	1	3	2	4	2	5	2	4	0	5			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chrX:53619384G>C	uc004dsp.2	-	33	4348	c.3946C>G	c.(3946-3948)CAA>GAA	p.Q1316E	HUWE1_uc004dsn.2_Missense_Mutation_p.Q141E	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1316	UBA.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TGGTTGACTTGAGGTTCCCGG	0.537													18	52					0	0	0	0	C	53619384	C	C	53619384	3	2	216	1	0	0	0	0	1	0	0	0	7500	1299	45	2	9386	2	HUWE1	23	53619384	Missense_Mutation	SNP	G	TCGA-CV-7089-01A-11D-2012-08	1398	53619384	101651176	192	39916											
ZMAT1	84460	broad.mit.edu	37	chrX	101152892	101152892	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgatcatgttcctccattaAttgcttcagttttttagcat	8	19	5	9	0	2	1	2	1	0	0	4	1	4	1	2	0	2	4	2	0	2	7			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chrX:101152892A>T	uc011mrl.1	-	5	765	c.454T>A	c.(454-456)TTA>ATA	p.L152I	ZMAT1_uc004ein.2_5'UTR|ZMAT1_uc011mrm.1_5'UTR	NM_001011657	NP_001011657	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						nucleus	zinc ion binding			ovary(1)	1						TCCTCCATTAATTGCTTCAGT	0.403													10	27					0	0	0	0	T	101152892	T	T	101152892	3	4	216	1	0	0	0	0	1	0	0	0	17758	98	4	5	1474	5	ZMAT1	23	101152892	Missense_Mutation	SNP	A	TCGA-CV-7089-01A-11D-2012-08	47533508	101152892	54117668	193	39917											
TCEAL3	85012	broad.mit.edu	37	chrX	102864119	102864120	+	Frame_Shift_Ins	INS	-	A	A																															agacgtggaggggaagacagINSaatgcgagggaaagagagag																										TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chrX:102864119_102864120insA	uc004ekq.2	+	3	389_390	c.127_128insA	c.(127-129)GAAfs	p.E43fs	TCEAL3_uc004ekr.2_Frame_Shift_Ins_p.E43fs	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	43	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						ggggaagacagaatgcgaggga	0.149													---	---	---								A	102864120	A	A	102864119	7	5	216	1	0	1	1	0	0	0	0	0	15738	943	33	0	129	0	TCEAL3	23	102864119	Frame_Shift_Ins	INS	-	TCGA-CV-7089-01A-11D-2012-08	1711227	102864119	52406441	194	39918											
ARHGEF6	9459	broad.mit.edu	37	chrX	135862907	135862907	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagccaggcatgagtctgttGatcagtttgcacagaactac	11	10	11	9	0	2	3	1	2	1	1	2	4	2	3	1	1	4	4	1	1	2	3			TCGA-CV-7089-01A-11D-2012-08	TCGA-CV-7089-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	125ccb76-bf8d-4ce7-a04c-4424d6da0322	41d9b9bd-e0fd-4abc-ad29-41ca136e3e0a	g.chrX:135862907G>A	uc004fab.2	-	1	597	c.135C>T	c.(133-135)ATC>ATT	p.I45I		NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	45	CH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					TGAGTCTGTTGATCAGTTTGC	0.433													9	114					0	0	0	0	A	135862907	A	A	135862907	2	1	216	1	0	0	0	0	0	0	0	1	910	1280	45	2		2	ARHGEF6	23	135862907	Silent	SNP	G	TCGA-CV-7089-01A-11D-2012-08	32998788	135862907	19407653	195	39919											
ARID1A	8289	broad.mit.edu	37	chr1	27099013	27099013	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggatcaggatctatgcagggGccccagactccccagtcaac	10	6	11	14	0	3	1	2	0	1	1	4	3	4	3	4	4	2	1	4	4	2	1			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr1:27099013G>C	uc001bmv.1	+	13	3802	c.3429G>C	c.(3427-3429)GGG>GGC	p.G1143G	ARID1A_uc001bmt.1_Silent_p.G1143G|ARID1A_uc001bmu.1_Silent_p.G1143G|ARID1A_uc001bmw.1_Silent_p.G760G|ARID1A_uc001bmx.1_5'UTR|ARID1A_uc009vsm.1_5'Flank|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1143					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTATGCAGGGGCCCCAGACTC	0.527			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								12	48					0	0	0	0	C	27099013	C	C	27099013	2	2	217	1	0	0	0	0	0	0	0	1	913	1190	42	4		4	ARID1A	1	27099013	Silent	SNP	G	TCGA-CV-7090-01A-11D-2012-08		27099013	222151608	1	39920											
CYP2J2	1573	broad.mit.edu	37	chr1	60381634	60381634	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttcttaaagatatgttctcGcataggggtcacggggcggt	8	13	13	7	3	3	1	1	0	2	1	4	1	3	1	0	5	0	2	0	5	4	5			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr1:60381634G>A	uc001czq.2	-	2	354	c.349C>T	c.(349-351)CGA>TGA	p.R117*		NM_000775	NP_000766	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J,	117					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			ovary(1)	1	all_cancers(7;0.000396)					ATATGTTCTCGCATAGGGGTC	0.428													15	98					0	0	0	0	A	60381634	A	A	60381634	4	1	217	1	0	0	0	0	0	1	0	0	4189	1095	38	1	1191	1	CYP2J2	1	60381634	Nonsense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	33282621	60381634	188868987	2	39921											
INADL	10207	broad.mit.edu	37	chr1	62593753	62593753	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcggagtggccgcacggaCacagaagcttaaagtaaacg	14	5	13	9	4	0	1	0	0	0	1	0	3	0	3	1	3	3	3	1	3	6	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr1:62593753C>T	uc001dab.2	+	40	5267	c.5153C>T	c.(5152-5154)ACA>ATA	p.T1718I	INADL_uc001dac.2_RNA|INADL_uc009wag.2_Missense_Mutation_p.T502I	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1718	PDZ 10.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						GCCGCACGGACACAGAAGCTT	0.488													5	37					0	0	0	0	T	62593753	T	T	62593753	3	4	217	1	0	0	0	0	1	0	0	0	7770	478	17	4	5307	4	INADL	1	62593753	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08	2212119	62593753	186656868	3	39922											
C1orf103	55791	broad.mit.edu	37	chr1	111495258	111495258	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtggaagagctggaaatcTgagtctgaaaagtaacttga	14	11	12	4	0	2	4	0	3	2	1	2	6	2	6	0	2	2	2	0	2	5	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr1:111495258T>G	uc001eaa.2	-	2	504	c.248A>C	c.(247-249)CAG>CCG	p.Q83P	C1orf103_uc001dzz.2_5'UTR|C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	83					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		GCTGGAAATCTGAGTCTGAAA	0.378													11	35					0	0	0	0	G	111495258	G	G	111495258	3	3	217	1	0	0	0	0	1	0	0	0	1986	1580	55	5	2073	5	C1orf103	1	111495258	Missense_Mutation	SNP	T	TCGA-CV-7090-01A-11D-2012-08	48901505	111495258	137755363	4	39923											
C1orf129	80133	broad.mit.edu	37	chr1	170961470	170961470	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accaacttgatgcctttggcGgtaaataacacgatgagtgt	12	11	10	8	2	0	2	0	2	0	0	0	3	0	2	2	2	3	1	2	2	4	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr1:170961470G>A	uc001ghg.2	+	12	1324	c.1194G>A	c.(1192-1194)GCG>GCA	p.A398A	C1orf129_uc009wvy.2_Silent_p.A205A|C1orf129_uc010plz.1_Silent_p.A398A	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	398							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGCCTTTGGCGGTAAATAACA	0.413													6	77					0	0	0	0	A	170961470	A	A	170961470	2	1	217	1	0	0	0	0	0	0	0	1	2005	1130	39	1		1	C1orf129	1	170961470	Silent	SNP	G	TCGA-CV-7090-01A-11D-2012-08	59466212	170961470	78289151	5	39924											
KIAA1383	54627	broad.mit.edu	37	chr1	232940983	232940984	+	Frame_Shift_Ins	INS	-	A	A																															cttaatacaaggttggtggcINSaaaaaacggctcacaagtat																										TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr1:232940983_232940984insA	uc001hvh.2	+	1	346_347	c.214_215insA	c.(214-216)CAAfs	p.Q72fs		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	Error:Variant_position_missing_in_Q9P2G4_after_alignment										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				AGGTTGGTGGCAAAAAACGGCT	0.45													---	---	---								A	232940984	A	A	232940983	7	5	217	1	0	1	1	0	0	0	0	0	8267	711	25	0	216	0	KIAA1383	1	232940983	Frame_Shift_Ins	INS	-	TCGA-CV-7090-01A-11D-2012-08	61979513	232940983	16309638	6	39925											
PLCD1	5333	broad.mit.edu	37	chr3	38058058	38058058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccagcacccagtgctgggCatcagctggcgatggggcga	7	5	15	14	2	1	0	1	0	0	0	1	2	1	0	3	4	3	4	3	4	0	0			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr3:38058058C>T	uc003chn.2	-	3	476	c.352G>A	c.(352-354)GCC>ACC	p.A118T	PLCD1_uc003chm.2_Missense_Mutation_p.A139T	NM_006225	NP_006216	P51178	PLCD1_HUMAN	phospholipase C, delta 1 isoform 2	118	PH.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CAGTGCTGGGCATCAGCTGGC	0.587													6	22					0	0	0	0	T	38058058	T	T	38058058	3	4	217	1	0	0	0	0	1	0	0	0	12086	710	25	4	1970	4	PLCD1	3	38058058	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08		38058058	159964372	7	39926											
CADM2	253559	broad.mit.edu	37	chr3	86028420	86028420	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaccacatctgcaacaacCagcagcatcagaggtacagt	15	5	7	14	0	2	1	1	0	1	1	2	1	2	1	3	1	7	4	3	1	4	1			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr3:86028420C>A	uc003dqj.2	+	8	1676	c.1050C>A	c.(1048-1050)ACC>ACA	p.T350T	CADM2_uc003dqk.2_Intron|CADM2_uc003dql.2_Silent_p.T352T	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	350	Thr-rich.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CTGCAACAACCAGCAGCATCA	0.433													24	163					2.41591e-17	1.90589e-16	1	0	A	86028420	A	A	86028420	2	1	217	1	0	0	0	0	0	0	0	1	2579	581	21	4		4	CADM2	3	86028420	Silent	SNP	C	TCGA-CV-7090-01A-11D-2012-08	47970362	86028420	111994010	8	39927											
NR1I2	8856	broad.mit.edu	37	chr3	119531666	119531666	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctctgcagctgcggggggAggatggcagtgtctggaact	6	9	17	9	1	2	0	0	0	2	0	3	3	2	3	0	6	4	3	0	6	1	0			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr3:119531666A>G	uc003edj.2	+	5	2492	c.653A>G	c.(652-654)GAG>GGG	p.E218G	NR1I2_uc003edi.2_Missense_Mutation_p.E181G|NR1I2_uc003edk.2_Missense_Mutation_p.E257G|NR1I2_uc003edl.2_Missense_Mutation_p.E106G	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	218	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	CTGCGGGGGGAGGATGGCAGT	0.582													5	69					0	0	0	0	G	119531666	G	G	119531666	3	3	217	1	0	0	0	0	1	0	0	0	10674	304	11	5	788	5	NR1I2	3	119531666	Missense_Mutation	SNP	A	TCGA-CV-7090-01A-11D-2012-08	33503246	119531666	78490764	9	39928											
IFT80	57560	broad.mit.edu	37	chr3	160025459	160025459	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caagatgcttacgagaacacGtaacattgaagagacgttga	16	8	10	7	3	0	5	0	2	0	3	0	7	0	5	0	0	4	3	0	0	5	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr3:160025459G>A	uc011boy.1	-	10	1501	c.1068C>T	c.(1066-1068)TAC>TAT	p.Y356Y	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Silent_p.Y219Y|IFT80_uc003fdd.1_Silent_p.Y39Y|IFT80_uc003fde.1_Silent_p.Y219Y	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	356						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ACGAGAACACGTAACATTGAA	0.368													8	34					0	0	0	0	A	160025459	A	A	160025459	2	1	217	1	0	0	0	0	0	0	0	1	7603	1140	40	1		1	IFT80	3	160025459	Silent	SNP	G	TCGA-CV-7090-01A-11D-2012-08	40493793	160025459	37996971	10	39929											
ZNF141	7700	broad.mit.edu	37	chr4	367159	367159	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catactggagagaaaccctaCaaatgtgaagaatgtggcaa	17	7	10	7	0	0	3	0	1	0	2	0	5	0	4	1	2	3	1	1	2	7	2			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr4:367159C>T	uc003gaa.2	+	5	1111	c.933C>T	c.(931-933)TAC>TAT	p.Y311Y	ZNF141_uc003gab.2_Intron	NM_003441	NP_003432	Q15928	ZN141_HUMAN	zinc finger protein 141	311	C2H2-type 6.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0						AGAAACCCTACAAATGTGAAG	0.393													35	62					0	0	0	0	T	367159	T	T	367159	2	4	217	1	0	0	0	0	0	0	0	1	17797	489	17	4		4	ZNF141	4	367159	Silent	SNP	C	TCGA-CV-7090-01A-11D-2012-08		367159	190787117	11	39930											
AFAP1	60312	broad.mit.edu	37	chr4	7857195	7857195	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagggctggccactcacttGatgtgatgtattccggagct	7	11	13	10	1	1	2	1	2	0	0	2	3	2	3	2	3	1	4	2	3	1	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr4:7857195G>A	uc003gkg.1	-	4	605	c.332C>T	c.(331-333)TCA>TTA	p.S111L	AFAP1_uc011bwk.1_Missense_Mutation_p.S111L	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	111						actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						CCACTCACTTGATGTGATGTA	0.562													13	45					0	0	0	0	A	7857195	A	A	7857195	3	1	217	1	0	0	0	0	1	0	0	0	353	1294	45	2	2172	2	AFAP1	4	7857195	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	7490036	7857195	183297081	12	39931											
FGB	2244	broad.mit.edu	37	chr4	155489613	155489613	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagttctgtcaaaccgtatAgagtatactgtgacatgaat	14	12	8	7	1	2	3	1	2	1	1	2	3	2	3	1	0	2	3	1	0	6	5			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr4:155489613A>T	uc003ioa.3	+	5	838	c.799A>T	c.(799-801)AGA>TGA	p.R267*	FGB_uc003iob.3_Nonsense_Mutation_p.R264*|FGB_uc010ipv.2_Nonsense_Mutation_p.R205*|FGB_uc010ipw.2_Nonsense_Mutation_p.R264*|FGB_uc003ioc.3_Nonsense_Mutation_p.R48*	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	267	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CAAACCGTATAGAGTATACTG	0.373													6	80					0	0	0	0	T	155489613	T	T	155489613	4	4	217	1	0	0	0	0	0	1	0	0	5863	412	15	5	817	5	FGB	4	155489613	Nonsense_Mutation	SNP	A	TCGA-CV-7090-01A-11D-2012-08	147632418	155489613	35664663	13	39932											
AGXT2	64902	broad.mit.edu	37	chr5	35014142	35014142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccattcccaatccctttaGccatggtgacaatgtcaggc	10	10	8	13	0	1	1	1	1	0	0	3	1	3	1	4	2	2	0	4	2	3	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr5:35014142G>A	uc003jjf.2	-	10	1125	c.1046C>T	c.(1045-1047)GCT>GTT	p.A349V	AGXT2_uc003jje.1_Missense_Mutation_p.A2V|AGXT2_uc011com.1_Intron	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	349					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	AATCCCTTTAGCCATGGTGAC	0.527													48	63					0	0	0	0	A	35014142	A	A	35014142	3	1	217	1	0	0	0	0	1	0	0	0	405	971	34	4	518	4	AGXT2	5	35014142	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08		35014142	145901118	14	39933											
CATSPER3	347732	broad.mit.edu	37	chr5	134303694	134303694	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggaaaatgtctcaacacCgtcaccagcgccactcgaga	12	8	8	13	3	2	1	2	0	1	1	4	3	2	2	3	1	2	0	3	1	3	1	rs140980095	byFrequency	TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr5:134303694C>T	uc003lag.2	+	1	81	c.13C>T	c.(13-15)CGT>TGT	p.R5C	PCBD2_uc011cxw.1_3'UTR	NM_178019	NP_821138	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	5	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTCTCAACACCGTCACCAGCG	0.388													3	27					0	0	0	0	T	134303694	T	T	134303694	3	4	217	1	0	0	0	0	1	0	0	0	2701	652	23	1	15	1	CATSPER3	5	134303694	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08	99289552	134303694	46611566	15	39934											
EYA4	2070	broad.mit.edu	37	chr6	133783832	133783832	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtccccattacagagtggCtgcctcagttacagcccagg	9	8	10	14	0	1	1	1	0	0	1	2	1	2	1	4	2	4	2	4	2	2	2			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr6:133783832C>A	uc003qec.3	+	9	1112	c.654C>A	c.(652-654)GGC>GGA	p.G218G	EYA4_uc011ecq.1_Silent_p.G164G|EYA4_uc011ecr.1_Silent_p.G164G|EYA4_uc003qed.3_Silent_p.G218G|EYA4_uc003qee.3_Silent_p.G195G|EYA4_uc011ecs.1_Silent_p.G218G|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	218					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TACAGAGTGGCTGCCTCAGTT	0.473													9	44					7.48243e-07	5.5504e-06	1	0	A	133783832	A	A	133783832	2	1	217	1	0	0	0	0	0	0	0	1	5356	784	28	4		4	EYA4	6	133783832	Silent	SNP	C	TCGA-CV-7090-01A-11D-2012-08		133783832	37331235	16	39935											
ABCB5	340273	broad.mit.edu	37	chr7	20725391	20725391	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaagaccaactcacttcctCtgcactctgtgaagagcatc	12	9	7	13	0	3	3	1	1	2	2	5	4	4	3	2	0	3	2	2	0	3	1			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr7:20725391C>T	uc003suw.3	+	7	1153	c.607C>T	c.(607-609)CTG>TTG	p.L203L	ABCB5_uc010kuh.2_Silent_p.L648L	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	203	Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CTCACTTCCTCTGCACTCTGT	0.398													6	24					0	0	0	0	T	20725391	T	T	20725391	2	4	217	1	0	0	0	0	0	0	0	1	44	912	32	2		2	ABCB5	7	20725391	Silent	SNP	C	TCGA-CV-7090-01A-11D-2012-08		20725391	138413272	17	39936											
NT5C3	51251	broad.mit.edu	37	chr7	33057128	33057128	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcttgacgaataacttcctCtagtacatcgccgattccag	11	11	7	12	3	1	1	0	1	1	0	4	3	3	1	3	0	3	2	3	0	4	6			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr7:33057128C>G	uc003tdk.2	-	7	708	c.631G>C	c.(631-633)GAG>CAG	p.E211Q	AVL9_uc011kai.1_Intron|NT5C3_uc003tdi.2_Missense_Mutation_p.E172Q|NT5C3_uc003tdj.2_Missense_Mutation_p.E172Q	NM_001002010	NP_001002010	Q9H0P0	5NT3_HUMAN	5'-nucleotidase, cytosolic III isoform 1	211					nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1			GBM - Glioblastoma multiforme(11;0.0894)			ATAACTTCCTCTAGTACATCG	0.378													9	60					0	0	0	0	G	33057128	G	G	33057128	3	3	217	1	0	0	0	0	1	0	0	0	10742	922	32	2	391	2	NT5C3	7	33057128	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08	12331737	33057128	126081535	18	39937											
BBS9	27241	broad.mit.edu	37	chr7	33390925	33390925	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgctgttgtttcttattcCagaccaacaggtaaacatac	13	13	6	9	0	1	1	0	0	1	1	2	1	2	1	2	1	4	4	2	1	6	6			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr7:33390925C>G	uc003tdn.1	+	14	2040	c.1527C>G	c.(1525-1527)TCC>TCG	p.S509S	BBS9_uc003tdo.1_Intron|BBS9_uc003tdp.1_Silent_p.S509S|BBS9_uc003tdq.1_Intron|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Silent_p.S33S|BBS9_uc003tds.1_5'UTR|BBS9_uc011kao.1_Silent_p.S387S	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	509					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TTTCTTATTCCAGACCAACAG	0.323									Bardet-Biedl_syndrome				5	49					0	0	0	0	G	33390925	G	G	33390925	2	3	217	1	0	0	0	0	0	0	0	1	1344	581	21	4		4	BBS9	7	33390925	Silent	SNP	C	TCGA-CV-7090-01A-11D-2012-08	333797	33390925	125747738	19	39938											
GRM8	2918	broad.mit.edu	37	chr7	126249445	126249445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctgattggtccagtggcCgatgactttgtactctgtgc	7	13	12	9	1	1	2	0	2	1	0	2	3	2	2	2	2	3	2	2	2	2	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr7:126249445C>T	uc003vlr.2	-	7	1776	c.1465G>A	c.(1465-1467)GGC>AGC	p.G489S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.G489S|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	489	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GTCCAGTGGCCGATGACTTTG	0.378										HNSCC(24;0.065)			15	93					0	0	0	0	T	126249445	T	T	126249445	3	4	217	1	0	0	0	0	1	0	0	0	6842	652	23	1	1327	1	GRM8	7	126249445	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08	92858520	126249445	32889218	20	39939											
TRIM24	8805	broad.mit.edu	37	chr7	138252356	138252356	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acgacaagcaataaagccaaAccccctacagatggctttct	15	7	6	13	1	1	1	0	0	1	1	1	2	1	1	3	1	4	2	3	1	6	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr7:138252356A>C	uc003vuc.2	+	10	1876	c.1661A>C	c.(1660-1662)AAC>ACC	p.N554T	TRIM24_uc003vub.2_Missense_Mutation_p.N520T	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	554					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						ATAAAGCCAAACCCCCTACAG	0.423													10	52					0	0	0	0	C	138252356	C	C	138252356	3	2	217	1	0	0	0	0	1	0	0	0	16565	43	2	5	1699	5	TRIM24	7	138252356	Missense_Mutation	SNP	A	TCGA-CV-7090-01A-11D-2012-08	12002911	138252356	20886307	21	39940											
LSM1	27257	broad.mit.edu	37	chr8	38021331	38021331	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcaatggatacttgctggaGgggtgtgtcactctcctttt	6	16	11	8	0	3	0	2	0	1	0	4	2	3	2	1	4	2	1	1	4	2	5			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr8:38021331G>T	uc003xkw.2	-	4	447	c.259C>A	c.(259-261)CTC>ATC	p.L87I	LSM1_uc003xkx.2_RNA	NM_014462	NP_055277	O15116	LSM1_HUMAN	Lsm1 protein	87					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|mRNA processing|RNA splicing, via transesterification reactions	cytosol|nucleus|ribonucleoprotein complex	protein binding|RNA binding				0	Colorectal(12;0.000442)					ACTTGCTGGAGGGGTGTGTCA	0.458													8	84					5.18039e-06	3.78626e-05	1	0	T	38021331	T	T	38021331	3	4	217	1	0	0	0	0	1	0	0	0	9100	1000	35	4	146	4	LSM1	8	38021331	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08		38021331	108342691	22	39941											
BAG4	9530	broad.mit.edu	37	chr8	38067634	38067634	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtgaacaatgatgattcaGatcttttggattcccaagtc	12	13	8	8	0	2	4	1	3	1	1	4	5	3	5	1	1	1	0	1	1	3	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr8:38067634G>C	uc003xky.1	+	5	1279	c.997G>C	c.(997-999)GAT>CAT	p.D333H	BAG4_uc003xkz.1_Missense_Mutation_p.D297H	NM_004874	NP_004865	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	333					anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				TGATGATTCAGATCTTTTGGA	0.463													12	121					0	0	0	0	C	38067634	C	C	38067634	3	2	217	1	0	0	0	0	1	0	0	0	1291	942	33	2	1015	2	BAG4	8	38067634	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	46303	38067634	108296388	23	39942											
BAG4	9530	broad.mit.edu	37	chr8	38067849	38067849	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaatttgtaggaaaaaaGacagacaaagcatactggct	19	7	10	5	0	0	3	0	0	0	3	0	5	0	4	0	2	2	3	0	2	8	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr8:38067849G>C	uc003xky.1	+	5	1494	c.1212G>C	c.(1210-1212)AAG>AAC	p.K404N	BAG4_uc003xkz.1_Missense_Mutation_p.K368N	NM_004874	NP_004865	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	404	BAG.				anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				TAGGAAAAAAGACAGACAAAG	0.423													4	81					0	0	0	0	C	38067849	C	C	38067849	3	2	217	1	0	0	0	0	1	0	0	0	1291	933	33	2	1230	2	BAG4	8	38067849	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	215	38067849	108296173	24	39943											
ODF1	4956	broad.mit.edu	37	chr8	103564263	103564263	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agccatagaagatgagaagcGagagcttgccaagtaaaata	18	6	11	6	1	0	4	0	1	0	4	0	6	0	4	2	0	4	2	2	0	7	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr8:103564263G>A	uc003ykt.2	+	1	416	c.308G>A	c.(307-309)CGA>CAA	p.R103Q		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	103					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			GATGAGAAGCGAGAGCTTGCC	0.358													14	101					0	0	0	0	A	103564263	A	A	103564263	3	1	217	1	0	0	0	0	1	0	0	0	10880	1058	37	1	310	1	ODF1	8	103564263	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	65496414	103564263	42799759	25	39944											
COL14A1	7373	broad.mit.edu	37	chr8	121259909	121259909	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaatggtataaccggttgcGcattacgtgggaccccccat	9	9	12	11	3	0	0	0	0	0	0	0	2	0	2	4	4	3	3	4	4	4	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr8:121259909G>A	uc003yox.2	+	21	2802	c.2537G>A	c.(2536-2538)CGC>CAC	p.R846H	COL14A1_uc003yoy.2_Missense_Mutation_p.R524H	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	846	Fibronectin type-III 7.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AACCGGTTGCGCATTACGTGG	0.458													33	71					0	0	0	0	A	121259909	A	A	121259909	3	1	217	1	0	0	0	0	1	0	0	0	3686	1087	38	1	2615	1	COL14A1	8	121259909	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	17695646	121259909	25104113	26	39945											
TJP2	9414	broad.mit.edu	37	chr9	71851111	71851111	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaactggctggctgtgaggAttgggaacgagttggagaaa	11	8	17	5	1	0	2	0	1	0	1	0	6	0	4	0	5	2	4	0	5	3	2			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr9:71851111A>T	uc004ahe.2	+	13	2148	c.1948A>T	c.(1948-1950)ATT>TTT	p.I650F	TJP2_uc011lrs.1_Missense_Mutation_p.I627F|TJP2_uc011lrt.1_Missense_Mutation_p.I627F|TJP2_uc004ahd.2_Missense_Mutation_p.I650F|TJP2_uc004ahf.2_Missense_Mutation_p.I650F|TJP2_uc011lru.1_Missense_Mutation_p.I654F|TJP2_uc011lrv.1_Missense_Mutation_p.I672F	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	650	SH3.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						GGCTGTGAGGATTGGGAACGA	0.522													9	63					0	0	0	0	T	71851111	T	T	71851111	3	4	217	1	0	0	0	0	1	0	0	0	15996	333	12	5	2155	5	TJP2	9	71851111	Missense_Mutation	SNP	A	TCGA-CV-7090-01A-11D-2012-08		71851111	69362320	27	39946											
KIAA1984	84960	broad.mit.edu	37	chr9	139700965	139700965	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttctgcagcttcaagtcCgttgagaagaaaatgacaga	13	9	10	9	1	2	4	1	2	1	3	3	5	3	4	2	0	2	3	2	0	4	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr9:139700965C>T	uc004cjf.2	+	11	1167	c.1119C>T	c.(1117-1119)TCC>TCT	p.S373S	C9orf86_uc004cjm.2_5'Flank|C9orf86_uc004cjh.2_5'Flank|C9orf86_uc004cjj.1_5'Flank|C9orf86_uc004cjk.1_5'Flank|C9orf86_uc004cji.1_5'Flank|C9orf86_uc010nbr.1_5'Flank|LOC100131193_uc004cjg.1_RNA	NM_001039374	NP_001034463	Q5T5S1	K1984_HUMAN	hypothetical protein LOC84960	373	Potential.									ovary(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.33e-06)|Epithelial(140;0.000124)		GCTTCAAGTCCGTTGAGAAGA	0.582													4	34					0	0	0	0	T	139700965	T	T	139700965	2	4	217	1	0	0	0	0	0	0	0	1	8305	639	23	1		1	KIAA1984	9	139700965	Silent	SNP	C	TCGA-CV-7090-01A-11D-2012-08	67849854	139700965	1512466	28	39947											
DUSP5	1847	broad.mit.edu	37	chr10	112257918	112257918	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacgggcgccagctgcgcaaGatgctccgcaaggaggcggc	8	3	17	13	5	0	1	0	0	0	1	1	3	1	2	2	4	3	4	2	4	2	0			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr10:112257918G>C	uc001kzd.2	+	1	294	c.39G>C	c.(37-39)AAG>AAC	p.K13N		NM_004419	NP_004410	Q16690	DUS5_HUMAN	dual specificity phosphatase 5	13					endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1		Breast(234;0.0848)		Epithelial(162;0.000276)|all cancers(201;0.00465)|BRCA - Breast invasive adenocarcinoma(275;0.12)		AGCTGCGCAAGATGCTCCGCA	0.537													8	24					0	0	0	0	C	112257918	C	C	112257918	3	2	217	1	0	0	0	0	1	0	0	0	4850	933	33	2	41	2	DUSP5	10	112257918	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08		112257918	23276829	29	39948											
METT5D1	196074	broad.mit.edu	37	chr11	28318421	28318421	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatcgcttcagcaattgttCaggcacgcagcatctacccc	11	9	7	14	2	3	0	2	0	1	0	4	0	3	0	2	1	3	6	2	1	3	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr11:28318421C>T	uc001msh.2	+	6	1176	c.721C>T	c.(721-723)CAG>TAG	p.Q241*	METT5D1_uc001msg.2_Nonsense_Mutation_p.Q241*|METT5D1_uc001mse.2_Missense_Mutation_p.S226L|METT5D1_uc001msi.2_Nonsense_Mutation_p.Q38*	NM_001113528	NP_001107000	A6NJ78	MET15_HUMAN	methyltransferase 5 domain containing 1 isoform	241							methyltransferase activity				0						AGCAATTGTTCAGGCACGCAG	0.453													11	68					0	0	0	0	T	28318421	T	T	28318421	4	4	217	1	0	0	0	0	0	1	0	0	9545	827	29	2	735	2	METT5D1	11	28318421	Nonsense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08		28318421	106688095	30	39949											
MADD	8567	broad.mit.edu	37	chr11	47305994	47305994	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattgacgagctgcagaatCagaaggaagcagaagagcct	16	5	13	7	1	1	6	1	1	0	5	1	8	1	7	1	1	4	3	1	1	4	1			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr11:47305994C>A	uc001ner.1	+	12	2226	c.2035C>A	c.(2035-2037)CAG>AAG	p.Q679K	MADD_uc001neq.2_Missense_Mutation_p.Q679K|MADD_uc001nev.1_Missense_Mutation_p.Q679K|MADD_uc001nes.1_Missense_Mutation_p.Q679K|MADD_uc001net.1_Missense_Mutation_p.Q679K|MADD_uc009yln.1_Missense_Mutation_p.Q679K|MADD_uc001neu.1_Missense_Mutation_p.Q679K|MADD_uc001nex.2_Missense_Mutation_p.Q679K|MADD_uc001nez.2_Missense_Mutation_p.Q679K|MADD_uc001new.2_Missense_Mutation_p.Q679K	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	679					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		GCTGCAGAATCAGAAGGAAGC	0.592													28	40					8.58068e-18	6.87839e-17	1	0	A	47305994	A	A	47305994	3	1	217	1	0	0	0	0	1	0	0	0	9203	827	29	2	2077	2	MADD	11	47305994	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08	18987573	47305994	87700522	31	39950											
NUMA1	4926	broad.mit.edu	37	chr11	71715073	71715073	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccttctttgaggctccccGccgcagaaggctgttcccta	5	10	11	15	2	1	2	0	1	1	1	3	2	3	2	5	3	0	4	5	3	2	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr11:71715073G>A	uc001orl.1	-	26	6368	c.6196C>T	c.(6196-6198)CGG>TGG	p.R2066W	IL18BP_uc009ysu.1_Intron|NUMA1_uc001orj.2_Missense_Mutation_p.R248W|NUMA1_uc009ysw.1_Missense_Mutation_p.R1633W|NUMA1_uc001ork.1_Missense_Mutation_p.R930W|NUMA1_uc001orm.1_Missense_Mutation_p.R2052W	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	2066					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						GAGGCTCCCCGCCGCAGAAGG	0.647			T	RARA	APL								24	136					0	0	0	0	A	71715073	A	A	71715073	3	1	217	1	0	0	0	0	1	0	0	0	10804	1086	38	1	159	1	NUMA1	11	71715073	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	24409079	71715073	63291443	32	39951											
FAT3	120114	broad.mit.edu	37	chr11	92088363	92088363	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catctgtttcctttgttgagGtggaagtggtggatgtcaat	7	16	13	5	0	2	1	1	1	1	0	3	3	3	3	1	4	0	2	1	4	2	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr11:92088363G>T	uc001pdj.3	+	1	3102	c.3085G>T	c.(3085-3087)GTG>TTG	p.V1029L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1029	Cadherin 9.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTTTGTTGAGGTGGAAGTGGT	0.458										TCGA Ovarian(4;0.039)			7	38					8.12818e-05	0.000585465	1	0	T	92088363	T	T	92088363	3	4	217	1	0	0	0	0	1	0	0	0	5723	1261	44	4	3087	4	FAT3	11	92088363	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	20373290	92088363	42918153	33	39952											
PTPRB	5787	broad.mit.edu	37	chr12	70974931	70974931	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctgtatctgctggtctcActggagatgctttcattttt	7	17	9	8	0	3	1	2	0	2	1	4	2	3	1	0	2	3	4	0	2	2	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr12:70974931A>G	uc001swb.3	-	8	1839	c.1809T>C	c.(1807-1809)AGT>AGC	p.S603S	PTPRB_uc010sto.1_Silent_p.S603S|PTPRB_uc010stp.1_Silent_p.S513S|PTPRB_uc001swc.3_Silent_p.S821S|PTPRB_uc001swa.3_Silent_p.S821S|PTPRB_uc001swd.3_Silent_p.S820S|PTPRB_uc009zrr.1_Silent_p.S700S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	603	Fibronectin type-III 7.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGCTGGTCTCACTGGAGATGC	0.473													16	78					0	0	0	0	G	70974931	G	G	70974931	2	3	217	1	0	0	0	0	0	0	0	1	12861	156	6	5		5	PTPRB	12	70974931	Silent	SNP	A	TCGA-CV-7090-01A-11D-2012-08		70974931	62876964	34	39953											
DIAPH3	81624	broad.mit.edu	37	chr13	60584694	60584694	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttcccctacaatgcataccGcagagagaagtttaaccaca	14	8	6	13	1	0	2	0	0	0	2	1	3	1	2	4	0	4	3	4	0	5	5			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr13:60584694G>A	uc001vht.2	-	8	1100	c.881C>T	c.(880-882)GCG>GTG	p.A294V	DIAPH3_uc001vhu.2_Missense_Mutation_p.A31V|DIAPH3_uc001vhw.1_Missense_Mutation_p.A283V|DIAPH3_uc010aed.1_Missense_Mutation_p.A248V|DIAPH3_uc010aee.1_Missense_Mutation_p.A224V|uc001vhx.2_5'Flank|uc001vhy.2_5'Flank	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	294	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AATGCATACCGCAGAGAGAAG	0.368													7	23					0	0	0	0	A	60584694	A	A	60584694	3	1	217	1	0	0	0	0	1	0	0	0	4542	1087	38	1	2804	1	DIAPH3	13	60584694	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08		60584694	54585184	35	39954											
PCNX	22990	broad.mit.edu	37	chr14	71444780	71444780	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagcagttttgattcaagcCggcatagggactatgtttgc	9	13	11	8	1	1	1	1	1	0	0	1	2	1	2	1	2	3	4	1	2	4	7			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr14:71444780C>T	uc001xmo.2	+	6	2172	c.1726C>T	c.(1726-1728)CGG>TGG	p.R576W	PCNX_uc001xmn.3_Missense_Mutation_p.R576W|PCNX_uc010are.1_Missense_Mutation_p.R576W	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	576						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGATTCAAGCCGGCATAGGGA	0.473													5	135					0	0	0	0	T	71444780	T	T	71444780	3	4	217	1	0	0	0	0	1	0	0	0	11645	643	23	1	1748	1	PCNX	14	71444780	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08		71444780	35904760	36	39955											
KIAA1409	57578	broad.mit.edu	37	chr14	94069729	94069729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgtggaatccaagagggCgctctccctccctgagaccc	7	7	11	16	1	1	2	0	1	1	2	4	4	3	3	5	2	0	1	5	2	2	0			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr14:94069729C>T	uc001ybv.1	+	23	3271	c.3188C>T	c.(3187-3189)GCG>GTG	p.A1063V	KIAA1409_uc001ybs.1_Missense_Mutation_p.A1063V	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1240						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TCCAAGAGGGCGCTCTCCCTC	0.493													13	77					0	0	0	0	T	94069729	T	T	94069729	3	4	217	1	0	0	0	0	1	0	0	0	8269	768	27	1	3278	1	KIAA1409	14	94069729	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08	22624949	94069729	13279811	37	39956											
GABRB3	2562	broad.mit.edu	37	chr15	26812809	26812809	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgttatcagtatagagggcaTataagtctgaagaatgaagt	15	11	11	4	1	2	4	1	2	1	2	2	4	2	4	0	1	0	3	0	1	8	5			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr15:26812809T>C	uc001zaz.2	-	7	896	c.754A>G	c.(754-756)ATG>GTG	p.M252V	GABRB3_uc010uae.1_Missense_Mutation_p.M167V|GABRB3_uc001zba.2_Missense_Mutation_p.M252V|GABRB3_uc001zbb.2_Missense_Mutation_p.M308V	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	252	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATAGAGGGCATATAAGTCTGA	0.428													9	30					0	0	0	0	C	26812809	C	C	26812809	3	2	217	1	0	0	0	0	1	0	0	0	6202	1406	49	5	679	5	GABRB3	15	26812809	Missense_Mutation	SNP	T	TCGA-CV-7090-01A-11D-2012-08		26812809	75718583	38	39957											
TUBB3	10381	broad.mit.edu	37	chr16	90001360	90001360	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccgcatcatgaacaccttCagcgtcgtgccctcacccaa	10	7	7	17	3	3	1	3	1	0	0	4	2	3	1	4	0	3	1	4	0	2	1			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr16:90001360C>T	uc002fph.1	+	4	566	c.501C>T	c.(499-501)TTC>TTT	p.F167F	TUBB3_uc002fpf.2_Silent_p.F514F|TUBB3_uc010ciz.1_Silent_p.F95F|TUBB3_uc002fpg.1_Silent_p.F21F|TUBB3_uc002fpi.1_Silent_p.F95F|TUBB3_uc002fpj.1_Silent_p.F95F|TUBB3_uc010cjb.1_Silent_p.F21F|TUBB3_uc002fpk.1_Silent_p.F21F	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	167					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		TGAACACCTTCAGCGTCGTGC	0.627													19	123					0	0	0	0	T	90001360	T	T	90001360	2	4	217	1	0	0	0	0	0	0	0	1	16825	825	29	2		2	TUBB3	16	90001360	Silent	SNP	C	TCGA-CV-7090-01A-11D-2012-08		90001360	353393	39	39958											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	12	6	8	15	2	1	0	1	0	0	0	3	1	3	1	3	2	2	4	3	2	2	1	rs28934576	by1000genomes	TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	17					0	0	0	0	T	7577120	T	T	7577120	3	4	217	1	0	0	0	0	1	0	0	0	16448	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08		7577120	73618090	40	39959											
ADAP2	55803	broad.mit.edu	37	chr17	29261281	29261281	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagtttgtacttctggcaaGagaaggcctcctgaagtact	11	11	11	8	0	1	2	0	1	1	1	2	4	2	2	2	2	2	4	2	2	6	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr17:29261281G>C	uc002hfx.2	+	5	755	c.476G>C	c.(475-477)AGA>ACA	p.R159T	ADAP2_uc010csk.2_Missense_Mutation_p.R165T|ADAP2_uc002hfy.2_Missense_Mutation_p.R159T|ADAP2_uc010csl.2_RNA	NM_018404	NP_060874	Q9NPF8	ADAP2_HUMAN	centaurin-alpha 2 protein	159	PH 1.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		ovary(1)	1						CTTCTGGCAAGAGAAGGCCTC	0.483													13	11					0	0	0	0	C	29261281	C	C	29261281	3	2	217	1	0	0	0	0	1	0	0	0	280	942	33	2	494	2	ADAP2	17	29261281	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	21684161	29261281	51933929	41	39960											
ABCC3	8714	broad.mit.edu	37	chr17	48745371	48745371	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	taatcagcaacctgactcagGtaaccctgggtagggctggg	10	8	13	10	0	2	1	2	1	0	0	2	1	2	1	2	4	3	4	2	4	4	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr17:48745371G>A	uc002isl.2	+	13	1862	c.1782_splice	c.e13+1	p.Q594_splice		NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3						bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCTGACTCAGGTAACCCTGGG	0.527													16	34					0	0	0	0	A	48745371	A	A	48745371	5	1	217	1	0	0	0	0	0	0	1	0	54	1275	44	4	1917	4	ABCC3	17	48745371	Splice_Site	SNP	G	TCGA-CV-7090-01A-11D-2012-08	19484090	48745371	32449839	42	39961											
TUBD1	51174	broad.mit.edu	37	chr17	57968230	57968230	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaagaatctttctttgcaaGatgcttgatatgcctcattc	10	16	7	8	0	3	4	1	2	2	2	4	4	3	4	1	0	3	2	1	0	4	5			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr17:57968230G>C	uc002ixw.1	-	2	412	c.134C>G	c.(133-135)TCT>TGT	p.S45C	TUBD1_uc010ddf.1_Missense_Mutation_p.S45C|TUBD1_uc010ddg.1_Missense_Mutation_p.S10C|TUBD1_uc010ddh.1_Translation_Start_Site|TUBD1_uc010wok.1_Missense_Mutation_p.S45C|TUBD1_uc002ixx.1_Missense_Mutation_p.S45C|TUBD1_uc010wol.1_Intron|TUBD1_uc010ddi.1_Missense_Mutation_p.S45C|RPS6KB1_uc010ddj.1_5'Flank|RPS6KB1_uc002ixy.2_5'Flank|RPS6KB1_uc010wom.1_5'Flank|RPS6KB1_uc010won.1_5'Flank	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	45					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			TTCTTTGCAAGATGCTTGATA	0.353													36	76					0	0	0	0	C	57968230	C	C	57968230	3	2	217	1	0	0	0	0	1	0	0	0	16830	942	33	2	1259	2	TUBD1	17	57968230	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	9222859	57968230	23226980	43	39962											
ACE	1636	broad.mit.edu	37	chr17	61570945	61570945	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatgaggccattggggacGtgctagccctctcagtgtct	6	11	12	12	1	2	1	1	1	2	0	4	2	3	2	3	3	2	1	3	3	1	2			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr17:61570945G>A	uc002jau.1	+	20	3083	c.3061G>A	c.(3061-3063)GTG>ATG	p.V1021M	ACE_uc002jav.1_Missense_Mutation_p.V447M|ACE_uc010ddv.1_Missense_Mutation_p.V248M|ACE_uc010wpj.1_Missense_Mutation_p.V447M|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.V267M	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	1021	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CATTGGGGACGTGCTAGCCCT	0.597													6	40					0	0	0	0	A	61570945	A	A	61570945	3	1	217	1	0	0	0	0	1	0	0	0	136	1145	40	1	3342	1	ACE	17	61570945	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	3602715	61570945	19624265	44	39963											
CABLES1	91768	broad.mit.edu	37	chr18	20833870	20833870	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccaaaattggaagtgacctCaaaaaacacgaagtcaagca	19	5	8	9	1	2	1	2	1	0	0	2	3	2	2	2	1	2	1	2	1	8	1			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr18:20833870C>G	uc002kuc.2	+	9	1731	c.1731C>G	c.(1729-1731)CTC>CTG	p.L577L	C18orf45_uc010xaq.1_Intron|CABLES1_uc002kub.2_Silent_p.L80L|CABLES1_uc002kud.2_Silent_p.L312L	NM_001100619	NP_001094089	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1 isoform 2	577					blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)	1	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GAAGTGACCTCAAAAAACACG	0.493													5	37					0	0	0	0	G	20833870	G	G	20833870	2	3	217	1	0	0	0	0	0	0	0	1	2541	813	29	2		2	CABLES1	18	20833870	Silent	SNP	C	TCGA-CV-7090-01A-11D-2012-08		20833870	57243378	45	39964											
LONP1	9361	broad.mit.edu	37	chr19	5705940	5705940	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaggcccagctccttctTgatgatctttagctgctcct	5	14	7	15	0	2	2	0	2	2	0	5	2	5	2	4	1	3	3	4	1	1	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr19:5705940T>C	uc002mcx.2	-	8	1243	c.1210A>G	c.(1210-1212)AAG>GAG	p.K404E	LONP1_uc002mcy.2_Missense_Mutation_p.K340E|LONP1_uc010duh.2_Missense_Mutation_p.K145E|LONP1_uc010dui.2_Missense_Mutation_p.K388E|LONP1_uc002mcz.2_Missense_Mutation_p.K208E	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	404					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						AGCTCCTTCTTGATGATCTTT	0.592													3	103					0	0	0	0	C	5705940	C	C	5705940	3	2	217	1	0	0	0	0	1	0	0	0	8942	1821	63	5	1713	5	LONP1	19	5705940	Missense_Mutation	SNP	T	TCGA-CV-7090-01A-11D-2012-08		5705940	53423043	46	39965											
TYK2	7297	broad.mit.edu	37	chr19	10476499	10476499	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aggaacctgcggaagacgttCcgaaggcgcagccgggtcag	10	4	16	11	5	1	1	1	0	0	1	2	4	2	3	3	4	3	2	3	4	3	1			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr19:10476499C>G	uc002moc.3	-	7	1083	c.705G>C	c.(703-705)CGG>CGC	p.R235R	TYK2_uc010dxe.2_Silent_p.R50R|TYK2_uc002mod.2_Silent_p.R235R	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	235	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GGAAGACGTTCCGAAGGCGCA	0.612													4	22					0	0	0	0	G	10476499	G	G	10476499	2	3	217	1	0	0	0	0	0	0	0	1	16878	842	30	2		2	TYK2	19	10476499	Silent	SNP	C	TCGA-CV-7090-01A-11D-2012-08	4770559	10476499	48652484	47	39966											
ZNF676	163223	broad.mit.edu	37	chr19	22364284	22364284	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaactaatttttaagtgtaAattctcatgtccacatttgt	13	17	4	7	0	1	0	1	0	1	0	3	0	2	0	1	0	1	1	1	0	5	7			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr19:22364284A>T	uc002nqs.1	-	3	553	c.235T>A	c.(235-237)TTA>ATA	p.L79I		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	79					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TTTAAGTGTAAATTCTCATGT	0.338													5	54					0	0	0	0	T	22364284	T	T	22364284	3	4	217	1	0	0	0	0	1	0	0	0	18150	11	1	5	1535	5	ZNF676	19	22364284	Missense_Mutation	SNP	A	TCGA-CV-7090-01A-11D-2012-08	11887785	22364284	36764699	48	39967											
CHST8	64377	broad.mit.edu	37	chr19	34263279	34263279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccaccgcgtgctctactgcGaggtgcccaaggccggctgc	5	6	14	16	4	1	0	0	0	1	0	1	1	1	0	4	3	5	2	4	3	2	1			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr19:34263279G>A	uc002nus.3	+	5	1091	c.586G>A	c.(586-588)GAG>AAG	p.E196K	CHST8_uc002nut.3_Missense_Mutation_p.E196K|CHST8_uc002nuu.2_Missense_Mutation_p.E196K	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	196	Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					GCTCTACTGCGAGGTGCCCAA	0.692													18	46					0	0	0	0	A	34263279	A	A	34263279	3	1	217	1	0	0	0	0	1	0	0	0	3425	1059	37	1	596	1	CHST8	19	34263279	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	11898995	34263279	24865704	49	39968											
ZNF146	7705	broad.mit.edu	37	chr19	36727775	36727775	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggcaaatccaaccttactGagcatgagaaaatccatatt	15	10	7	9	0	0	2	0	2	0	1	2	3	2	2	3	1	3	2	3	1	6	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr19:36727775G>A	uc002odq.3	+	4	1956	c.433G>A	c.(433-435)GAG>AAG	p.E145K	ZNF146_uc010eet.2_Missense_Mutation_p.E145K|ZNF146_uc010eeu.2_Missense_Mutation_p.E145K	NM_007145	NP_009076	Q15072	OZF_HUMAN	zinc finger protein 146	145	C2H2-type 5.				regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding				0	Esophageal squamous(110;0.162)					CAACCTTACTGAGCATGAGAA	0.418													8	84					0	0	0	0	A	36727775	A	A	36727775	3	1	217	1	0	0	0	0	1	0	0	0	17800	1291	45	2	435	2	ZNF146	19	36727775	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	2464496	36727775	22401208	50	39969											
ZFP112	7771	broad.mit.edu	37	chr19	44833908	44833908	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attcctgcccaaacctggccGagggaattaccttgttcttg	8	12	9	12	1	1	0	0	0	1	0	2	2	2	1	5	2	3	1	5	2	3	5	rs147887844		TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr19:44833908G>A	uc010ejj.2	-	5	533	c.420C>T	c.(418-420)CTC>CTT	p.L140L	ZFP112_uc002ozc.3_Silent_p.L134L|ZFP112_uc010xwy.1_Silent_p.L157L|ZFP112_uc010xwz.1_Silent_p.L139L	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						AAACCTGGCCGAGGGAATTAC	0.403													9	46					0	0	0	0	A	44833908	A	A	44833908	2	1	217	1	0	0	0	0	0	0	0	1	17705	1045	37	1		1	ZFP112	19	44833908	Silent	SNP	G	TCGA-CV-7090-01A-11D-2012-08	8106133	44833908	14295075	51	39970											
BCAM	4059	broad.mit.edu	37	chr19	45317520	45317520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggacggcagccccagccCggagtatacgcttttccgcc	6	6	14	15	4	0	0	0	0	0	0	1	2	1	2	5	4	3	3	5	4	2	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr19:45317520C>T	uc002ozu.2	+	7	940	c.896C>T	c.(895-897)CCG>CTG	p.P299L	BCAM_uc002ozt.1_Missense_Mutation_p.P299L	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	299	Extracellular (Potential).|Ig-like C2-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				AGCCCCAGCCCGGAGTATACG	0.657													20	72					0	0	0	0	T	45317520	T	T	45317520	3	4	217	1	0	0	0	0	1	0	0	0	1346	652	23	1	922	1	BCAM	19	45317520	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08	483612	45317520	13811463	52	39971											
ZNF480	147657	broad.mit.edu	37	chr19	52825750	52825750	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaactttcaaatcttgcacGacatcgaagaattcatactg	14	12	5	10	2	4	1	3	0	1	1	5	3	4	1	0	0	3	1	0	0	5	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr19:52825750G>A	uc010ydl.1	+	5	1317	c.1247G>A	c.(1246-1248)CGA>CAA	p.R416Q	ZNF480_uc002pyv.2_Missense_Mutation_p.R339Q|ZNF480_uc010ydm.1_Missense_Mutation_p.R373Q|ZNF480_uc010epn.2_Missense_Mutation_p.R247Q|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	416	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		AATCTTGCACGACATCGAAGA	0.368													12	87					0	0	0	0	A	52825750	A	A	52825750	3	1	217	1	0	0	0	0	1	0	0	0	18002	1058	37	1	1261	1	ZNF480	19	52825750	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	7508230	52825750	6303233	53	39972											
PAK7	57144	broad.mit.edu	37	chr20	9546621	9546621	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtttccctgtgtgtttctcGgtggcgatgcatacgatgcc	4	15	12	10	3	1	0	0	0	1	0	3	2	2	0	2	2	3	3	2	2	1	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr20:9546621G>A	uc002wnl.2	-	6	1946	c.1401C>T	c.(1399-1401)ACC>ACT	p.T467T	PAK7_uc002wnk.2_Silent_p.T467T|PAK7_uc002wnj.2_Silent_p.T467T|PAK7_uc010gby.1_Silent_p.T467T	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	467	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TGTGTTTCTCGGTGGCGATGC	0.522													22	144					0	0	0	0	A	9546621	A	A	9546621	2	1	217	1	0	0	0	0	0	0	0	1	11459	1103	39	1		1	PAK7	20	9546621	Silent	SNP	G	TCGA-CV-7090-01A-11D-2012-08		9546621	53478899	54	39973											
RUNX1	861	broad.mit.edu	37	chr21	36171600	36171601	+	Frame_Shift_Ins	INS	-	A	A																															gttttcaagtggcttacttgINSagagtcgactggaaagttct																										TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr21:36171600_36171601insA	uc002yuh.2	-	5	2461_2462	c.883_884insT	c.(883-885)TCAfs	p.S295fs	RUNX1_uc002yui.2_Frame_Shift_Ins_p.S231fs|RUNX1_uc010gmu.2_Frame_Shift_Ins_p.S322fs|RUNX1_uc010gmv.2_Frame_Shift_Ins_p.S322fs|RUNX1_uc002yuj.3_Frame_Shift_Ins_p.S190fs|RUNX1_uc002yuk.3_Frame_Shift_Ins_p.S322fs|RUNX1_uc002yul.1_Frame_Shift_Ins_p.S87fs|RUNX1_uc002yum.1_Frame_Shift_Ins_p.S126fs	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	295	Interaction with MYST3.|Pro/Ser/Thr-rich.			Missing: No DNA-binding.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.S322fs*160(1)		haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						TGGCTTACTTGAGAGTCGACTG	0.52			T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				---	---	---								A	36171601	A	A	36171600	7	5	217	1	0	1	1	0	0	0	0	0	13811	1294	45	0	485	0	RUNX1	21	36171600	Frame_Shift_Ins	INS	-	TCGA-CV-7090-01A-11D-2012-08		36171600	11958295	55	39974											
ADRBK2	157	broad.mit.edu	37	chr22	26083560	26083560	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgttctctgagaaggagatgCggttttatgccactgaaatc	10	13	11	7	1	1	3	0	2	1	2	3	5	1	3	1	2	2	2	1	2	3	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chr22:26083560C>T	uc003abx.3	+	11	1030	c.883C>T	c.(883-885)CGG>TGG	p.R295W	ADRBK2_uc010gux.2_Missense_Mutation_p.R295W|ADRBK2_uc003abw.2_Missense_Mutation_p.R182W|ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	295	Protein kinase.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	GAAGGAGATGCGGTTTTATGC	0.418													8	52					0	0	0	0	T	26083560	T	T	26083560	3	4	217	1	0	0	0	0	1	0	0	0	344	759	27	1	925	1	ADRBK2	22	26083560	Missense_Mutation	SNP	C	TCGA-CV-7090-01A-11D-2012-08		26083560	25221006	56	39975											
TBX22	50945	broad.mit.edu	37	chrX	79282319	79282319	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggtgttaaaacattctcCtttaaagaaactgagttcac	15	12	7	7	0	2	2	1	1	1	1	3	3	2	2	1	1	2	2	1	1	6	5			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chrX:79282319C>A	uc010nmg.1	+	6	884	c.750C>A	c.(748-750)TCC>TCA	p.S250S	TBX22_uc004edi.1_Silent_p.S130S|TBX22_uc004edj.1_Silent_p.S250S	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	250	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						AAACATTCTCCTTTAAAGAAA	0.478													22	15					1.10513e-12	8.45002e-12	1	0	A	79282319	A	A	79282319	2	1	217	1	0	0	0	0	0	0	0	1	15724	668	24	4		4	TBX22	23	79282319	Silent	SNP	C	TCGA-CV-7090-01A-11D-2012-08		79282319	75988241	57	39976											
HPRT1	3251	broad.mit.edu	37	chrX	133609219	133609219	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatttctgtaggactgaacGtcttgctcgagatgtgatga	9	15	11	6	2	2	4	0	3	2	1	3	6	2	5	0	1	2	2	0	1	3	4			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chrX:133609219G>A	uc004exl.3	+	3	310	c.143G>A	c.(142-144)CGT>CAT	p.R48H	HPRT1_uc010nrs.2_RNA	NM_000194	NP_000185	P00492	HPRT_HUMAN	hypoxanthine phosphoribosyltransferase 1	48			R -> H (in GOUT-HPRT; AD and DD).		adenine salvage|central nervous system neuron development|cerebral cortex neuron differentiation|cytolysis|dendrite morphogenesis|GMP catabolic process|GMP salvage|grooming behavior|guanine salvage|hypoxanthine salvage|IMP salvage|lymphocyte proliferation|positive regulation of dopamine metabolic process|protein homotetramerization|purine ribonucleoside salvage|response to amphetamine|striatum development	cytosol	guanine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity|magnesium ion binding|nucleotide binding|protein homodimerization activity				0	Acute lymphoblastic leukemia(192;0.000127)				Mercaptopurine(DB01033)|Thioguanine(DB00352)	AGGACTGAACGTCTTGCTCGA	0.368													7	25					0	0	0	0	A	133609219	A	A	133609219	3	1	217	1	0	0	0	0	1	0	0	0	7377	1145	40	1	153	1	HPRT1	23	133609219	Missense_Mutation	SNP	G	TCGA-CV-7090-01A-11D-2012-08	54326900	133609219	21661341	58	39977											
MAGEA12	4111	broad.mit.edu	37	chrX	151896231	151896231	+	RNA	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctggtcggagtggctggAtagtgttggcccactccatt	5	12	15	9	1	0	0	0	0	0	0	2	2	1	2	2	6	0	3	2	6	1	3			TCGA-CV-7090-01A-11D-2012-08	TCGA-CV-7090-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	5c636c2d-f426-43a9-984d-b4455e4388e5	c956aeba-c031-410c-84af-af79863b044d	g.chrX:151896231A>G	uc004fgb.2	-	4		c.536T>C						P43365	MAGAC_HUMAN	Homo sapiens melanoma antigen family A, 12, mRNA (cDNA clone MGC:4914 IMAGE:3450217), complete cds.											skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTGGCTGGATAGTGTTGGC	0.517													5	33					0	0	0	0	G	151896231	G	G	151896231	1	3	217	0	1	0	0	0	0	0	0	0	9217	348	12	5		5	MAGEA12	23	151896231	RNA	SNP	A	TCGA-CV-7090-01A-11D-2012-08	18287012	151896231	3374329	59	39978											
PRDM16	63976	broad.mit.edu	37	chr1	3322204	3322204	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatccacagcacggtgaagcCtttcatatgtgagtggtcgc	9	11	11	10	2	1	2	1	2	0	0	3	2	2	2	2	2	2	1	2	2	3	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:3322204C>T	uc001akf.2	+	8	1258	c.1178C>T	c.(1177-1179)CCT>CTT	p.P393L	PRDM16_uc001akc.2_Missense_Mutation_p.P393L|PRDM16_uc001akd.2_Missense_Mutation_p.P393L|PRDM16_uc001ake.2_Missense_Mutation_p.P393L|PRDM16_uc009vlh.2_Missense_Mutation_p.P94L	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	393					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		ACGGTGAAGCCTTTCATATGT	0.701			T	EVI1	MDS|AML								14	76					0	0	0	0	T	3322204	T	T	3322204	3	4	218	1	0	0	0	0	1	0	0	0	12519	681	24	4	1208	4	PRDM16	1	3322204	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08		3322204	245928417	1	39979											
CASZ1	54897	broad.mit.edu	37	chr1	10719786	10719786	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagacggtccccgtggtgAtggagtctgttttggagaag	7	11	17	6	2	1	3	0	1	1	2	2	6	2	4	2	5	0	1	2	5	1	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:10719786A>T	uc001aro.2	-	6	1633	c.1313T>A	c.(1312-1314)ATC>AAC	p.I438N	CASZ1_uc001arp.1_Missense_Mutation_p.I438N|CASZ1_uc009vmx.2_Missense_Mutation_p.I462N|CASZ1_uc001arq.1_Missense_Mutation_p.I297N	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CCCCGTGGTGATGGAGTCTGT	0.632													13	60					0	0	0	0	T	10719786	T	T	10719786	3	4	218	1	0	0	0	0	1	0	0	0	2697	333	12	5	4034	5	CASZ1	1	10719786	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	7397582	10719786	238530835	2	39980											
RBBP4	5928	broad.mit.edu	37	chr1	33134662	33134664	+	In_Frame_Del	DEL	AGA	-	-																															acagggcatacggcagtagtAgaagatgtttcctggcatct																										TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:33134662_33134664delAGA	uc001bvr.2	+	6	849_851	c.690_692delAGA	c.(688-693)GTAGAA>GTA	p.E231del	RBBP4_uc001bvs.2_In_Frame_Del_p.E230del|RBBP4_uc010ohj.1_5'UTR|RBBP4_uc010ohk.1_In_Frame_Del_p.E196del	NM_005610	NP_005601	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4 isoform a	231	WD 3.				cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CGGCAGTAGTAGAAGATGTTTCC	0.433													---	---	---								-	33134664	-	-	33134662	7	5	218	1	0	1	0	1	0	0	0	0	13166	407	15	0	712	0	RBBP4	1	33134662	In_Frame_Del	DEL	AGA	TCGA-CV-7091-01A-11D-2012-08	22414876	33134662	216115959	3	39981											
RPF1	80135	broad.mit.edu	37	chr1	84946675	84946675	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaaaaaacttaaaaaagaaAgagaggctcttggcgataag	21	6	10	4	1	1	3	0	0	1	3	1	5	1	3	0	2	1	1	0	2	8	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:84946675A>G	uc001djv.3	+	2	310	c.265A>G	c.(265-267)AGA>GGA	p.R89G		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	89					rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						TAAAAAAGAAAGAGAGGCTCT	0.303													29	35					0	0	0	0	G	84946675	G	G	84946675	3	3	218	1	0	0	0	0	1	0	0	0	13611	64	3	5	271	5	RPF1	1	84946675	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	51812013	84946675	164303946	4	39982											
COL11A1	1301	broad.mit.edu	37	chr1	103480090	103480090	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcctgctgaagaatagcttGagcctgagcttcctgagcag	10	9	12	10	0	0	5	0	4	0	1	1	5	1	5	3	0	6	4	3	0	3	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:103480090G>C	uc001dul.2	-	13	1867	c.1549C>G	c.(1549-1551)CAA>GAA	p.Q517E	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.Q529E|COL11A1_uc001dun.2_Missense_Mutation_p.Q478E|COL11A1_uc009weh.2_Missense_Mutation_p.Q401E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	517	Telopeptide.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGAATAGCTTGAGCCTGAGCT	0.418													8	31					0	0	0	0	C	103480090	C	C	103480090	3	2	218	1	0	0	0	0	1	0	0	0	3682	1299	45	2	4091	2	COL11A1	1	103480090	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	18533415	103480090	145770531	5	39983											
PRPF38B	55119	broad.mit.edu	37	chr1	109241970	109241980	+	Frame_Shift_Del	DEL	GGGGTTAGAAC	-	-																															agatcccgaagtattgaccgGgggttagaacgcaggcgcag																								rs3210429		TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:109241970_109241980delGGGGTTAGAAC	uc001dvv.3	+	6	1251_1261	c.969_979delGGGGTTAGAAC	c.(967-981)CGGGGGTTAGAACGCfs	p.R323fs	PRPF38B_uc001dvw.3_Frame_Shift_Del_p.R212fs|PRPF38B_uc010ouz.1_Frame_Shift_Del_p.R126fs	NM_018061	NP_060531	Q5VTL8	PR38B_HUMAN	PRP38 pre-mRNA processing factor 38 (yeast)	323_327	Arg-rich.				mRNA processing|RNA splicing	spliceosomal complex					0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		GTATTGACCGGGGGTTAGAACGCAGGCGCAG	0.422													---	---	---								-	109241980	-	-	109241970	7	5	218	1	0	1	0	1	0	0	0	0	12630	1219	43	0	991	0	PRPF38B	1	109241970	Frame_Shift_Del	DEL	GGGGTTAGAAC	TCGA-CV-7091-01A-11D-2012-08	5761880	109241970	140008651	6	39984											
RPTN	126638	broad.mit.edu	37	chr1	152128471	152128471	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccttgtctgtttggttgActgtagtgggaaccctggcc	5	14	13	9	0	1	2	0	2	1	0	1	3	1	3	3	3	1	3	3	3	2	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:152128471A>T	uc001ezs.1	-	3	1169	c.1104T>A	c.(1102-1104)AGT>AGA	p.S368R		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	368	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						TGTTTGGTTGACTGTAGTGGG	0.463													146	756					0	0	0	0	T	152128471	T	T	152128471	3	4	218	1	0	0	0	0	1	0	0	0	13729	272	10	5	1254	5	RPTN	1	152128471	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	42886501	152128471	97122150	7	39985											
NUP210L	91181	broad.mit.edu	37	chr1	154029336	154029336	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tattttcttcccatcttgtcCttggcaatagccacaagtgt	8	16	6	11	0	2	0	0	0	2	0	4	0	4	0	3	1	1	1	3	1	4	7			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:154029336C>T	uc001fdw.2	-	23	3267	c.3195G>A	c.(3193-3195)AAG>AAA	p.K1065K	NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Silent_p.K1065K	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1065						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CCATCTTGTCCTTGGCAATAG	0.388													6	66					0	0	0	0	T	154029336	T	T	154029336	2	4	218	1	0	0	0	0	0	0	0	1	10815	680	24	4		4	NUP210L	1	154029336	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08	1900865	154029336	95221285	8	39986											
FCRL4	83417	broad.mit.edu	37	chr1	157557696	157557696	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatttgatctaaatacatcaTtctcgtctccatatccaatg	13	15	3	10	1	4	1	1	1	3	0	7	1	5	1	2	0	1	0	2	0	6	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:157557696T>A	uc001fqw.2	-	4	657	c.521A>T	c.(520-522)AAT>ATT	p.N174I	FCRL4_uc010phy.1_Intron	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	174	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				AAATACATCATTCTCGTCTCC	0.318													6	19					0	0	0	0	A	157557696	A	A	157557696	3	1	218	1	0	0	0	0	1	0	0	0	5829	1493	52	5	1062	5	FCRL4	1	157557696	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	3528360	157557696	91692925	9	39987											
KIRREL	55243	broad.mit.edu	37	chr1	158046036	158046036	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacgggctggccctgggcatGggccagggcctcaaaggtga	7	5	18	11	1	1	1	1	1	0	0	1	2	1	1	3	6	0	2	3	6	1	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:158046036G>C	uc001frn.3	+	2	590	c.186G>C	c.(184-186)ATG>ATC	p.M62I	KIRREL_uc010pib.1_Intron|KIRREL_uc009wsq.2_Missense_Mutation_p.M1I	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	62	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CCCTGGGCATGGGCCAGGGCC	0.602													40	98					0	0	0	0	C	158046036	C	C	158046036	3	2	218	1	0	0	0	0	1	0	0	0	8363	1348	47	4	192	4	KIRREL	1	158046036	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	488340	158046036	91204585	10	39988											
USP21	27005	broad.mit.edu	37	chr1	161130531	161130531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accatttgcccccagggcccGcagcaaggagcgcagaaacc	11	3	11	16	2	0	1	0	0	0	1	0	2	0	2	5	2	4	3	5	2	2	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:161130531G>A	uc010pke.1	+	3	478	c.101G>A	c.(100-102)CGC>CAC	p.R34H	USP21_uc010pkc.1_Missense_Mutation_p.R34H|USP21_uc010pkd.1_Missense_Mutation_p.R34H|USP21_uc010pkf.1_Missense_Mutation_p.R34H	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	34					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCCAGGGCCCGCAGCAAGGAG	0.632													43	88					0	0	0	0	A	161130531	A	A	161130531	3	1	218	1	0	0	0	0	1	0	0	0	17121	1087	38	1	103	1	USP21	1	161130531	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	3084495	161130531	88120090	11	39989											
PIK3C2B	5287	broad.mit.edu	37	chr1	204403072	204403072	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgaagacaaagggggcaCggtccctgagccaaggggaa	13	3	17	8	1	0	3	0	2	0	1	1	4	1	4	2	6	1	1	2	6	4	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:204403072C>T	uc001haw.2	-	26	4171	c.3692G>A	c.(3691-3693)CGT>CAT	p.R1231H	PIK3C2B_uc010pqv.1_Missense_Mutation_p.R1203H	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1231	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			AAAGGGGGCACGGTCCCTGAG	0.557													8	62					0	0	0	0	T	204403072	T	T	204403072	3	4	218	1	0	0	0	0	1	0	0	0	11965	536	19	1	1248	1	PIK3C2B	1	204403072	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	43272541	204403072	44847549	12	39990											
MTR	4548	broad.mit.edu	37	chr1	237060420	237060420	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaagatttccaaggatcaggTaagctagctgttgcattata	13	12	10	6	0	1	1	1	0	0	1	2	3	2	2	1	2	3	5	1	2	6	6			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr1:237060420T>C	uc001hyi.3	+	32	4134	c.3711_splice	c.e32+2	p.Q1237_splice	MTR_uc010pxw.1_Splice_Site_p.Q830_splice|MTR_uc010pxx.1_Splice_Site_p.Q1186_splice|MTR_uc010pxy.1_Splice_Site_p.Q1091_splice	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine						nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AAGGATCAGGTAAGCTAGCTG	0.403													19	99					0	0	0	0	C	237060420	C	C	237060420	5	2	218	1	0	0	0	0	0	0	1	0	10011	1652	57	5	3839	5	MTR	1	237060420	Splice_Site	SNP	T	TCGA-CV-7091-01A-11D-2012-08	32657348	237060420	12190201	13	39991											
LTBP1	4052	broad.mit.edu	37	chr2	33412051	33412051	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagcgtgcctaaactttatCagcattcccagcagccaggc	10	8	8	15	1	1	0	1	0	0	0	2	0	2	0	4	1	6	2	4	1	3	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:33412051C>T	uc002ros.2	+	6	1330	c.1330C>T	c.(1330-1332)CAG>TAG	p.Q444*	LTBP1_uc002rot.2_Nonsense_Mutation_p.Q118*|LTBP1_uc002rou.2_Nonsense_Mutation_p.Q118*|LTBP1_uc002rov.2_Nonsense_Mutation_p.Q118*|LTBP1_uc010ymz.1_Nonsense_Mutation_p.Q118*|LTBP1_uc010yna.1_Nonsense_Mutation_p.Q118*	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	444					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TAAACTTTATCAGCATTCCCA	0.512													18	50					0	0	0	0	T	33412051	T	T	33412051	4	4	218	1	0	0	0	0	0	1	0	0	9123	827	29	2	1407	2	LTBP1	2	33412051	Nonsense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08		33412051	209787322	14	39992											
CTNNA2	1496	broad.mit.edu	37	chr2	80097053	80097053	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttaactatgtagcagcaagaAgacaacaggtgggaaagatt	17	8	11	5	0	0	3	0	0	0	3	0	4	0	4	0	2	4	3	0	2	7	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:80097053A>G	uc010ysh.1	+	4	582	c.577A>G	c.(577-579)AGA>GGA	p.R193G	CTNNA2_uc010yse.1_Missense_Mutation_p.R193G|CTNNA2_uc010ysf.1_Missense_Mutation_p.R193G|CTNNA2_uc010ysg.1_Missense_Mutation_p.R193G	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	193					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AGCAGCAAGAAGACAACAGGT	0.403													16	68					0	0	0	0	G	80097053	G	G	80097053	3	3	218	1	0	0	0	0	1	0	0	0	4030	64	3	5	591	5	CTNNA2	2	80097053	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	46685002	80097053	163102320	15	39993											
NEB	4703	broad.mit.edu	37	chr2	152586143	152586143	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttacctctcccggcacctCttcgtaaaccacttcttctg	6	13	4	18	2	4	0	0	0	4	0	6	0	4	0	5	1	2	2	5	1	3	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:152586143C>T	uc010fnx.2	-	4	255	c.64G>A	c.(64-66)GAG>AAG	p.E22K		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	22					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCCGGCACCTCTTCGTAAACC	0.493													42	65					0	0	0	0	T	152586143	T	T	152586143	3	4	218	1	0	0	0	0	1	0	0	0	10356	922	32	2	26338	2	NEB	2	152586143	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	72489090	152586143	90613230	16	39994											
SCN9A	6335	broad.mit.edu	37	chr2	167060716	167060716	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatttgtcactaggtcaaatAtacatccttggattttgttc	10	17	7	7	0	2	0	2	0	0	0	4	2	3	1	1	2	1	1	1	2	4	8			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:167060716A>G	uc010fpl.2	-	26	4831	c.4490T>C	c.(4489-4491)ATA>ACA	p.I1497T	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1508						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TAGGTCAAATATACATCCTTG	0.318													17	24					0	0	0	0	G	167060716	G	G	167060716	3	3	218	1	0	0	0	0	1	0	0	0	13990	449	16	5	1451	5	SCN9A	2	167060716	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	14474573	167060716	76138657	17	39995											
TTN	7273	broad.mit.edu	37	chr2	179528604	179528604	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagggcactttctcttcgcgGataacctctttggaagcttc	8	13	9	11	2	2	0	0	0	2	0	5	2	2	2	1	3	2	2	1	3	3	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:179528604G>A	uc010zfk.1	-	15	1376	c.828C>T	c.(826-828)ATC>ATT	p.I276I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCTTCGCGGATAACCTCTT	0.423													84	202					0	0	0	0	A	179528604	A	A	179528604	2	1	218	1	0	0	0	0	0	0	0	1	16803	1189	41	2		2	TTN	2	179528604	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	12467888	179528604	63670769	18	39996											
COL5A2	1290	broad.mit.edu	37	chr2	189906418	189906418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaccaactgggcctggaggaCcctgcaagaaacaaagactg	14	4	12	11	0	0	2	0	0	0	2	0	5	0	4	3	3	3	1	3	3	4	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:189906418C>T	uc002uqk.2	-	50	3802	c.3527G>A	c.(3526-3528)GGT>GAT	p.G1176D	COL5A2_uc010frx.2_Missense_Mutation_p.G752D	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1176					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GCCTGGAGGACCCTGCAAGAA	0.448													29	74					0	0	0	0	T	189906418	T	T	189906418	3	4	218	1	0	0	0	0	1	0	0	0	3712	521	18	4	992	4	COL5A2	2	189906418	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	10377814	189906418	53292955	19	39997											
DNAH7	56171	broad.mit.edu	37	chr2	196718132	196718132	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggaaatgaggatatcccCagtcaagttgatgtacagct	13	9	12	7	0	1	2	1	2	0	0	2	5	2	5	2	3	2	3	2	3	4	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:196718132C>A	uc002utj.3	-	46	8817	c.8716G>T	c.(8716-8718)GGG>TGG	p.G2906W		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2906					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGGATATCCCCAGTCAAGTTG	0.507													22	23					1.28384e-07	2.5221e-07	1	0	A	196718132	A	A	196718132	3	1	218	1	0	0	0	0	1	0	0	0	4628	594	21	4	3438	4	DNAH7	2	196718132	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	6811714	196718132	46481241	20	39998											
MDH1B	130752	broad.mit.edu	37	chr2	207605810	207605810	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctagatttttttcttcatcaGggaccagatctttatgtcct	8	18	6	9	0	4	2	2	0	2	2	5	3	5	3	2	1	0	0	2	1	2	7			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr2:207605810G>A	uc002vbs.2	-	10	1482	c.1427C>T	c.(1426-1428)CCT>CTT	p.P476L	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.P476L|MDH1B_uc010fuj.2_Missense_Mutation_p.P378L|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	476					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TTCTTCATCAGGGACCAGATC	0.333													20	25					0	0	0	0	A	207605810	A	A	207605810	3	1	218	1	0	0	0	0	1	0	0	0	9462	1000	35	4	141	4	MDH1B	2	207605810	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	10887678	207605810	35593563	21	39999											
TBC1D5	9779	broad.mit.edu	37	chr3	17418038	17418038	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgggctgtgcagactcactgGcatgtagaaaagcttggtgg	9	10	15	7	0	1	2	1	0	0	2	1	2	1	2	0	4	2	5	0	4	3	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:17418038G>C	uc003cbf.2	-	10	2345	c.680C>G	c.(679-681)GCC>GGC	p.A227G	TBC1D5_uc010hev.2_Missense_Mutation_p.A227G|TBC1D5_uc003cbe.2_Missense_Mutation_p.A227G|TBC1D5_uc010hew.1_Missense_Mutation_p.A179G	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	227	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						AGACTCACTGGCATGTAGAAA	0.403													19	36					0	0	0	0	C	17418038	C	C	17418038	3	2	218	1	0	0	0	0	1	0	0	0	15689	1203	42	4	1829	4	TBC1D5	3	17418038	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08		17418038	180604392	22	40000											
AZI2	64343	broad.mit.edu	37	chr3	28365639	28365639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccccaaatgctgtctcaCttgatttaggaggacttgga	9	14	9	9	0	1	1	1	1	1	0	3	4	2	4	2	3	1	1	2	3	2	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:28365639C>T	uc003ceb.2	-	8	1605	c.1073G>A	c.(1072-1074)AGT>AAT	p.S358N	AZI2_uc003cec.2_Missense_Mutation_p.S246N|AZI2_uc003ced.2_3'UTR	NM_022461	NP_071906	Q9H6S1	AZI2_HUMAN	5-azacytidine induced 2 isoform a	358						mitochondrion|plasma membrane				ovary(2)	2						TGCTGTCTCACTTGATTTAGG	0.398													32	43					0	0	0	0	T	28365639	T	T	28365639	3	4	218	1	0	0	0	0	1	0	0	0	1243	565	20	4	109	4	AZI2	3	28365639	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	10947601	28365639	169656791	23	40001											
SEMA3B	7869	broad.mit.edu	37	chr3	50313227	50313227	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagccccgctcgctgcaggcGcgcgtggagtggactttcca	5	7	15	14	5	0	0	0	0	0	0	2	3	1	2	3	3	2	3	3	3	0	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:50313227G>A	uc003cyu.2	+	18	2039	c.1797G>A	c.(1795-1797)GCG>GCA	p.A599A	SEMA3B_uc003cyt.2_Silent_p.A598A|SEMA3B_uc003cyv.2_Silent_p.A486A|SEMA3B_uc003cyw.2_Silent_p.A322A|SEMA3B_uc010hli.2_Silent_p.A491A|SEMA3B_uc003cyx.2_Silent_p.A485A|SEMA3B_uc003cyy.2_Silent_p.A256A|SEMA3B_uc011bdo.1_Silent_p.A256A	NM_004636	NP_004627	Q13214	SEM3B_HUMAN	semaphorin 3B isoform 1 precursor	599	Ig-like C2-type.				axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			lung(2)|central_nervous_system(2)|kidney(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CGCTGCAGGCGCGCGTGGAGT	0.692													13	19					0	0	0	0	A	50313227	A	A	50313227	2	1	218	1	0	0	0	0	0	0	0	1	14090	1074	38	1		1	SEMA3B	3	50313227	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	21947588	50313227	147709203	24	40002											
IFRD2	7866	broad.mit.edu	37	chr3	50330076	50330076	+	5'Flank	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgccctgcgcgcgccccagcCccgcgtcgggaacaagtgca	6	4	13	18	6	0	0	0	0	0	0	1	1	0	1	5	1	5	1	5	1	2	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:50330076C>A	uc011bdp.1	-						IFRD2_uc003czb.2_Missense_Mutation_p.G77C	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2								binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCGCCCCAGCCCCGCGTCGGG	0.657													20	32					2.94398e-08	5.92365e-08	1	0	A	50330076	A	A	50330076	1	1	218	0	1	0	0	0	0	0	0	0	7593	638	22	4		4	IFRD2	3	50330076	5'Flank	SNP	C	TCGA-CV-7091-01A-11D-2012-08	16849	50330076	147692354	25	40003											
OR5H14	403273	broad.mit.edu	37	chr3	97868655	97868655	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atgaccaatggactgtgcatCcggctattaatcttgtcata	11	13	8	9	1	2	1	1	1	1	0	3	2	3	2	2	2	1	2	2	2	4	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:97868655C>G	uc003dsg.1	+	1	426	c.426C>G	c.(424-426)ATC>ATG	p.I142M		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	142	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GACTGTGCATCCGGCTATTAA	0.393													16	162					0	0	0	0	G	97868655	G	G	97868655	3	3	218	1	0	0	0	0	1	0	0	0	11214	845	30	2	428	2	OR5H14	3	97868655	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	47538579	97868655	100153775	26	40004											
ABI3BP	25890	broad.mit.edu	37	chr3	100493490	100493490	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggatcagtttctcttgttGggcttgagctaaagtcagtt	8	15	12	6	0	3	1	2	1	1	0	4	3	3	2	0	2	1	5	0	2	2	6			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:100493490G>T	uc003dun.2	-	28	2442	c.2357C>A	c.(2356-2358)CCA>CAA	p.P786Q	ABI3BP_uc003duj.2_Missense_Mutation_p.P366Q|ABI3BP_uc003duk.2_Missense_Mutation_p.P495Q|ABI3BP_uc003dul.2_Missense_Mutation_p.P616Q|ABI3BP_uc011bhd.1_Missense_Mutation_p.P740Q|ABI3BP_uc003dum.2_Missense_Mutation_p.P197Q	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	786						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						TTCTCTTGTTGGGCTTGAGCT	0.343													3	8					0.004672	0.00891439	1	0	T	100493490	T	T	100493490	3	4	218	1	0	0	0	0	1	0	0	0	91	1348	47	4	902	4	ABI3BP	3	100493490	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	2624835	100493490	97528940	27	40005											
ILDR1	286676	broad.mit.edu	37	chr3	121712107	121712107	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtggggagtgcgagccgcGgcggtgggcccgccagctct	3	6	20	12	5	1	0	0	0	1	0	1	2	1	1	3	5	3	1	3	5	0	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:121712107G>A	uc003ees.2	-	7	1595	c.1489C>T	c.(1489-1491)CGC>TGC	p.R497C	ILDR1_uc003eeq.2_Missense_Mutation_p.R465C|ILDR1_uc003eer.2_Missense_Mutation_p.R453C|ILDR1_uc010hrg.2_Missense_Mutation_p.R408C	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	497	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		TGCGAGCCGCGGCGGTGGGCC	0.632													10	27					0	0	0	0	A	121712107	A	A	121712107	3	1	218	1	0	0	0	0	1	0	0	0	7748	1116	39	1	159	1	ILDR1	3	121712107	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	21218617	121712107	76310323	28	40006											
SHOX2	6474	broad.mit.edu	37	chr3	157815817	157815817	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attggtgctggcgttggcgtCacagacccagggctgcggcg	5	8	17	11	4	1	1	1	0	0	1	1	1	1	1	1	5	2	3	1	5	0	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:157815817C>T	uc003fbr.2	-	5	1134	c.995G>A	c.(994-996)TGA>TAA	p.*332*	SHOX2_uc003fbs.2_Silent_p.*356*|SHOX2_uc010hvw.2_Silent_p.*320*	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	332					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			GCGTTGGCGTCACAGACCCAG	0.657													141	470					0	0	0	0	T	157815817	T	T	157815817	2	4	218	1	0	0	0	0	0	0	0	1	14354	837	29	2		2	SHOX2	3	157815817	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08	36103710	157815817	40206613	29	40007											
NLGN1	22871	broad.mit.edu	37	chr3	173996813	173996813	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagaagaagccttacaaagAacttgttgaccaagatattc	17	9	7	8	0	0	5	0	1	0	4	1	5	0	5	2	0	3	1	2	0	7	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:173996813A>T	uc003fio.1	+	6	1445	c.1022A>T	c.(1021-1023)GAA>GTA	p.E341V	NLGN1_uc010hww.1_Missense_Mutation_p.E381V|NLGN1_uc003fip.1_Missense_Mutation_p.E341V	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	358	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CCTTACAAAGAACTTGTTGAC	0.423													43	123					0	0	0	0	T	173996813	T	T	173996813	3	4	218	1	0	0	0	0	1	0	0	0	10515	246	9	5	1036	5	NLGN1	3	173996813	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	16180996	173996813	24025617	30	40008											
ATP13A3	79572	broad.mit.edu	37	chr3	194152587	194152587	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtagaatcattccacaatcTctggccacagagacagcagt	13	8	9	11	0	2	2	1	0	1	2	4	3	3	2	2	2	1	2	2	2	3	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:194152587T>A	uc003fty.3	-	21	2682	c.2280A>T	c.(2278-2280)AGA>AGT	p.R760S	ATP13A3_uc003ftz.1_Missense_Mutation_p.R466S	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	760					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TTCCACAATCTCTGGCCACAG	0.353													10	44					0	0	0	0	A	194152587	A	A	194152587	3	1	218	1	0	0	0	0	1	0	0	0	1127	1548	54	5	1448	5	ATP13A3	3	194152587	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	20155774	194152587	3869843	31	40009											
DLG1	1739	broad.mit.edu	37	chr3	197009585	197009585	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggctgcttggcagtgtctCtgaagtcacagtagagcttg	9	11	13	8	0	2	2	1	1	1	1	3	2	2	2	0	2	2	5	0	2	3	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr3:197009585C>G	uc003fxo.3	-	4	473	c.283G>C	c.(283-285)GAG>CAG	p.E95Q	DLG1_uc011bud.1_5'UTR|DLG1_uc003fxn.3_Missense_Mutation_p.E95Q|DLG1_uc011bue.1_Missense_Mutation_p.E95Q|DLG1_uc010ial.2_Missense_Mutation_p.E95Q|DLG1_uc011buf.1_RNA|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Missense_Mutation_p.E95Q	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	95					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GGCAGTGTCTCTGAAGTCACA	0.398													14	150					0	0	0	0	G	197009585	G	G	197009585	3	3	218	1	0	0	0	0	1	0	0	0	4576	922	32	2	2627	2	DLG1	3	197009585	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	2856998	197009585	1012845	32	40010											
TADA2B	93624	broad.mit.edu	37	chr4	7056447	7056447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagtcggcagagtacgaggCagcgcggcataaacgggaga	13	3	17	8	5	0	3	0	0	0	3	1	5	0	3	0	4	3	4	0	4	3	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr4:7056447C>T	uc003gjw.3	+	2	1080	c.929C>T	c.(928-930)GCA>GTA	p.A310V	TADA2B_uc010idi.2_Missense_Mutation_p.A235V	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0						GAGTACGAGGCAGCGCGGCAT	0.557													28	36					0	0	0	0	T	7056447	T	T	7056447	3	4	218	1	0	0	0	0	1	0	0	0	15577	710	25	4	935	4	TADA2B	4	7056447	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08		7056447	184097829	33	40011											
C4orf21	55345	broad.mit.edu	37	chr4	113540154	113540155	+	Frame_Shift_Del	DEL	TG	-	-																															tgggccttgggtttcctttcTgtatcattcccatctacagt																										TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr4:113540154_113540155delTG	uc003iau.2	-	6	1254_1255	c.1043_1044delCA	c.(1042-1044)ACAfs	p.T348fs	C4orf21_uc003iaw.2_Frame_Shift_Del_p.T348fs	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GTTTCCTTTCTGTATCATTCCC	0.366													---	---	---								-	113540155	-	-	113540154	7	5	218	1	0	1	0	1	0	0	0	0	2264	1567	55	0	5362	0	C4orf21	4	113540154	Frame_Shift_Del	DEL	TG	TCGA-CV-7091-01A-11D-2012-08	106483707	113540154	77614122	34	40012											
POU4F2	5458	broad.mit.edu	37	chr4	147560567	147560567	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggctatgcggagagcctgtcTtccaaccccaccggtgcgta	7	8	12	14	3	1	1	0	0	1	1	2	2	2	1	5	3	4	2	5	3	3	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr4:147560567T>A	uc003ikv.2	+	1	523	c.275T>A	c.(274-276)CTT>CAT	p.L92H		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	92					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					AGAGCCTGTCTTCCAACCCCA	0.308													14	22					0	0	0	0	A	147560567	A	A	147560567	3	1	218	1	0	0	0	0	1	0	0	0	12334	1609	56	5	277	5	POU4F2	4	147560567	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	34020413	147560567	43593709	35	40013											
TMEM192	201931	broad.mit.edu	37	chr4	166000814	166000814	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgaccgtgagcctctcacGttctacttggctgacagccc	7	10	9	15	2	2	3	1	3	2	0	3	3	2	3	3	1	3	2	3	1	1	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr4:166000814G>C	uc003iqz.3	-	6	911	c.812C>G	c.(811-813)ACG>AGG	p.T271R		NM_001100389	NP_001093859	Q8IY95	TM192_HUMAN	transmembrane protein 192	271	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|late endosome|lysosomal membrane|nucleus				skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0926)		AGCCTCTCACGTTCTACTTGG	0.527													6	17					0	0	0	0	C	166000814	C	C	166000814	3	2	218	1	0	0	0	0	1	0	0	0	16181	1145	40	3	7	3	TMEM192	4	166000814	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	18440247	166000814	25153462	36	40014											
FAT1	2195	broad.mit.edu	37	chr4	187627774	187627774	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccatctctaatggagtatcGgatctccccatctcttctgg	7	13	8	13	1	4	0	0	0	4	0	8	2	4	2	3	3	0	1	3	3	2	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr4:187627774G>A	uc003izf.2	-	2	3396	c.3208C>T	c.(3208-3210)CGA>TGA	p.R1070*	FAT1_uc010iso.1_Nonsense_Mutation_p.R1070*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1070	Extracellular (Potential).|Cadherin 9.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATGGAGTATCGGATCTCCCCA	0.443										HNSCC(5;0.00058)			49	70					0	0	0	0	A	187627774	A	A	187627774	4	1	218	1	0	0	0	0	0	1	0	0	5721	1124	39	1	10662	1	FAT1	4	187627774	Nonsense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	21626960	187627774	3526502	37	40015											
DNAH5	1767	broad.mit.edu	37	chr5	13719088	13719088	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaatgggaaactgcttatgAgcctcggtggtcatccagag	10	10	13	8	1	1	2	1	1	0	1	3	3	2	3	2	3	3	2	2	3	3	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:13719088A>G	uc003jfd.2	-	72	12444	c.12402T>C	c.(12400-12402)GCT>GCC	p.A4134A	DNAH5_uc003jfc.2_Silent_p.A302A	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4134	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACTGCTTATGAGCCTCGGTGG	0.468									Kartagener_syndrome				25	115					0	0	0	0	G	13719088	G	G	13719088	2	3	218	1	0	0	0	0	0	0	0	1	4626	291	11	5		5	DNAH5	5	13719088	Silent	SNP	A	TCGA-CV-7091-01A-11D-2012-08		13719088	167196172	38	40016											
TRIO	7204	broad.mit.edu	37	chr5	14387624	14387624	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcatgcccatgcggcagaGataaaaaaatgtgttactgc	13	8	12	8	1	0	1	0	0	0	1	0	2	0	1	1	2	4	3	1	2	5	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:14387624G>A	uc003jff.2	+	22	3654	c.3648G>A	c.(3646-3648)GAG>GAA	p.E1216E	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.E1167E|TRIO_uc003jfh.1_Silent_p.E865E	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1216	Spectrin 4.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					ATGCGGCAGAGATAAAAAAAT	0.438													5	137					0	0	0	0	A	14387624	A	A	14387624	2	1	218	1	0	0	0	0	0	0	0	1	16619	933	33	2		2	TRIO	5	14387624	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	668536	14387624	166527636	39	40017											
LMBRD2	92255	broad.mit.edu	37	chr5	36124341	36124341	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaatgggtgattatacttGatgctttcattcactttacg	9	17	7	8	1	3	2	3	2	0	0	3	2	3	2	0	1	3	1	0	1	4	7			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:36124341G>C	uc003jkb.1	-	7	1189	c.774C>G	c.(772-774)ATC>ATG	p.I258M		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	258	Cytoplasmic (Potential).|Potential.					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GATTATACTTGATGCTTTCAT	0.269													5	30					0	0	0	0	C	36124341	C	C	36124341	3	2	218	1	0	0	0	0	1	0	0	0	8885	1280	45	2	1361	2	LMBRD2	5	36124341	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	21736717	36124341	144790919	40	40018											
NIPBL	25836	broad.mit.edu	37	chr5	37057315	37057315	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acgtgactatgctcttgtatAtagcagacaatctagcctgt	11	13	8	9	1	2	2	0	1	2	1	2	2	2	2	1	0	3	3	1	0	6	6			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:37057315A>G	uc003jkl.3	+	43	7790	c.7291A>G	c.(7291-7293)ATA>GTA	p.I2431V	NIPBL_uc003jkk.3_Missense_Mutation_p.I2431V|NIPBL_uc003jkn.2_Missense_Mutation_p.I124V	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2431					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GCTCTTGTATATAGCAGACAA	0.358													13	49					0	0	0	0	G	37057315	G	G	37057315	3	3	218	1	0	0	0	0	1	0	0	0	10482	449	16	5	7457	5	NIPBL	5	37057315	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	932974	37057315	143857945	41	40019											
ADAMTS6	11174	broad.mit.edu	37	chr5	64521916	64521916	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtaaaatctgagcaaccttGcattctccattgatgcagat	13	12	7	9	0	2	3	0	2	2	1	3	3	2	3	2	0	4	4	2	0	3	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:64521916G>T	uc003jtp.2	-	16	2878	c.2064C>A	c.(2062-2064)TGC>TGA	p.C688*	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Nonsense_Mutation_p.C309*	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	688					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		GAGCAACCTTGCATTCTCCAT	0.373													14	14					9.05144e-12	1.85499e-11	1	0	T	64521916	T	T	64521916	4	4	218	1	0	0	0	0	0	1	0	0	270	1311	46	4	1329	4	ADAMTS6	5	64521916	Nonsense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	27464601	64521916	116393344	42	40020											
COL4A3BP	10087	broad.mit.edu	37	chr5	74696051	74696051	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttttggacaaatctatgtgtCcccacagaagaaaaggcatc	14	10	8	9	0	1	2	0	0	1	2	3	3	2	3	2	2	0	1	2	2	5	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:74696051C>G	uc011csu.1	-	10	1511	c.1089G>C	c.(1087-1089)GGG>GGC	p.G363G	COL4A3BP_uc003kds.2_Silent_p.G363G|COL4A3BP_uc003kdt.2_Silent_p.G491G|COL4A3BP_uc003kdu.2_Silent_p.G363G	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	363					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		ATCTATGTGTCCCCACAGAAG	0.348													7	10					0	0	0	0	G	74696051	G	G	74696051	2	3	218	1	0	0	0	0	0	0	0	1	3707	842	30	2		2	COL4A3BP	5	74696051	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08	10174135	74696051	106219209	43	40021											
PCDHA13	56136	broad.mit.edu	37	chr5	140263365	140263365	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggtgggcgagcgtgcgctGtcgagctacgtgtcggtgca	4	8	19	10	7	0	0	0	0	0	0	2	2	0	0	0	3	5	3	0	3	1	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:140263365G>A	uc003lif.2	+	1	1512	c.1512G>A	c.(1510-1512)CTG>CTA	p.L504L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.L504L|PCDHA13_uc003lid.2_Silent_p.L504L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	504	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGTGCGCTGTCGAGCTACG	0.672													37	61					0	0	0	0	A	140263365	A	A	140263365	2	1	218	1	0	0	0	0	0	0	0	1	11577	1364	48	4		4	PCDHA13	5	140263365	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	65567314	140263365	40651895	44	40022											
FCHSD1	89848	broad.mit.edu	37	chr5	141026991	141026991	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggttgtctgctccccgcggtGggcatgctccaggatgacct	4	10	14	13	2	1	1	0	1	1	0	3	2	3	2	4	4	2	4	4	4	0	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr5:141026991G>A	uc003llk.2	-	9	853	c.802C>T	c.(802-804)CAC>TAC	p.H268Y	FCHSD1_uc010jgg.2_5'UTR|FCHSD1_uc003llj.2_RNA	NM_033449	NP_258260	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	268									FCHSD1/BRAF(2)	skin(2)|ovary(1)|central_nervous_system(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCCGCGGTGGGCATGCTCC	0.622													9	10					0	0	0	0	A	141026991	A	A	141026991	3	1	218	1	0	0	0	0	1	0	0	0	5821	1348	47	4	1318	4	FCHSD1	5	141026991	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	763626	141026991	39888269	45	40023											
HLA-DOA	3111	broad.mit.edu	37	chr6	32975992	32975992	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtgaactggcccgaggcGccgtaagactggtagaaggc	9	6	17	9	3	0	3	0	1	0	2	0	4	0	3	2	5	1	2	2	5	4	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:32975992G>A	uc003ocr.2	-	2	205	c.129C>T	c.(127-129)GGC>GGT	p.G43G	HLA-DOA_uc010juj.2_Silent_p.G13G|HLA-DOA_uc010jui.2_Silent_p.G43G	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	43	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						GGCCCGAGGCGCCGTAAGACT	0.537													14	47					0	0	0	0	A	32975992	A	A	32975992	2	1	218	1	0	0	0	0	0	0	0	1	7239	1074	38	1		1	HLA-DOA	6	32975992	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08		32975992	138139075	46	40024											
ZNF318	24149	broad.mit.edu	37	chr6	43322436	43322436	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcacggttcttctcatcaGagatcttctctggattatat	10	15	7	9	1	5	1	2	0	4	1	7	3	5	2	0	2	1	2	0	2	3	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:43322436G>A	uc003oux.2	-	4	2714	c.2636C>T	c.(2635-2637)TCT>TTT	p.S879F	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	879	Potential.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTTCTCATCAGAGATCTTCTC	0.438													24	43					0	0	0	0	A	43322436	A	A	43322436	3	1	218	1	0	0	0	0	1	0	0	0	17903	942	33	2	4231	2	ZNF318	6	43322436	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	10346444	43322436	127792631	47	40025											
POLH	5429	broad.mit.edu	37	chr6	43582058	43582058	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaggaccaagtgccctgtGagaagtgtggctccctggta	8	9	14	10	0	0	2	0	2	0	1	1	4	1	3	3	3	1	2	3	3	3	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:43582058G>A	uc003ovq.3	+	11	2210	c.1906G>A	c.(1906-1908)GAG>AAG	p.E636K	POLH_uc010jyu.2_Missense_Mutation_p.E512K|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_Missense_Mutation_p.E537K	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	636					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			AGTGCCCTGTGAGAAGTGTGG	0.502								DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum				32	136					0	0	0	0	A	43582058	A	A	43582058	3	1	218	1	0	0	0	0	1	0	0	0	12257	1291	45	2	1944	2	POLH	6	43582058	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	259622	43582058	127533009	48	40026											
PGK2	5232	broad.mit.edu	37	chr6	49754449	49754449	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctagcttggaaagtgatgctCggaaggcttctattttatct	9	15	10	7	1	2	1	0	1	2	0	3	3	2	3	0	3	2	3	0	3	5	6			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:49754449C>T	uc003ozu.2	-	1	559	c.452G>A	c.(451-453)CGA>CAA	p.R151Q		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	151					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					AAGTGATGCTCGGAAGGCTTC	0.498													19	83					0	0	0	0	T	49754449	T	T	49754449	3	4	218	1	0	0	0	0	1	0	0	0	11846	884	31	1	805	1	PGK2	6	49754449	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	6172391	49754449	121360618	49	40027											
GCLC	2729	broad.mit.edu	37	chr6	53373486	53373486	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacacatagcctcggtaaaaGggagatgcagcactcaaagc	15	5	11	10	1	1	1	1	0	0	1	2	3	1	1	1	2	4	3	1	2	4	2	rs17879847	byFrequency	TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:53373486G>T	uc003pbw.1	-	8	1240	c.852C>A	c.(850-852)CCC>CCA	p.P284P	GCLC_uc003pbv.1_Silent_p.P8P	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	284					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	CTCGGTAAAAGGGAGATGCAG	0.443													13	95					3.27435e-08	6.50949e-08	1	0	T	53373486	T	T	53373486	2	4	218	1	0	0	0	0	0	0	0	1	6330	987	35	4		4	GCLC	6	53373486	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	3619037	53373486	117741581	50	40028											
ZBTB2	57621	broad.mit.edu	37	chr6	151686959	151686959	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accatggtgtaagtgtcgatGctctggttgaggcacacgtg	8	11	14	8	2	1	1	0	1	1	0	2	2	1	1	1	3	1	4	1	3	1	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr6:151686959G>C	uc003qoh.2	-	3	1377	c.1242C>G	c.(1240-1242)AGC>AGG	p.S414R		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		AAGTGTCGATGCTCTGGTTGA	0.512													7	49					0	0	0	0	C	151686959	C	C	151686959	3	2	218	1	0	0	0	0	1	0	0	0	17595	1310	46	4	306	4	ZBTB2	6	151686959	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	98313473	151686959	19428108	51	40029											
TMEM106B	54664	broad.mit.edu	37	chr7	12263954	12263954	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacgtgaaatacattggtgtAaaatcagcctatgtcagtta	14	12	9	6	1	2	1	2	1	0	0	2	2	2	1	1	1	2	2	1	1	6	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr7:12263954A>G	uc011jxk.1	+	5	784	c.384A>G	c.(382-384)GTA>GTG	p.V128V	TMEM106B_uc003ssh.2_Silent_p.V128V	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	128						integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		ACATTGGTGTAAAATCAGCCT	0.343													44	105					0	0	0	0	G	12263954	G	G	12263954	2	3	218	1	0	0	0	0	0	0	0	1	16087	349	13	5		5	TMEM106B	7	12263954	Silent	SNP	A	TCGA-CV-7091-01A-11D-2012-08		12263954	146874709	52	40030											
NPC1L1	29881	broad.mit.edu	37	chr7	44579405	44579406	+	Missense_Mutation	DNP	GC	AA	AA																															ttgagccagcgctgggcattGcaaagggcagagccatacac																										TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr7:44579405_44579406GC>AA	uc003tlb.2	-	2	646_647	c.590_591GC>TT	c.(589-591)TGC>TTT	p.C197F	NPC1L1_uc003tlc.2_Missense_Mutation_p.C197F|NPC1L1_uc011kbw.1_Missense_Mutation_p.C197F|NPC1L1_uc003tld.2_Missense_Mutation_p.C197F	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	197	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCTGGGCATTGCAAAGGGCAGA	0.634													25	66					0	0	0	0	AA	44579406	AA	AA	44579405	3	1	218	1	0	0	0	0	1	0	0	0	10625	1311	46	4	3564	4	NPC1L1	7	44579405	Missense_Mutation	DNP	GC	TCGA-CV-7091-01A-11D-2012-08	32315451	44579405	114559258	53	40031											
SLC25A13	10165	broad.mit.edu	37	chr7	95775995	95775995	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggatttgtgaaaatcaccTgggagcctccagcctaaaaa	15	8	9	9	0	1	1	1	1	0	0	2	3	2	3	4	2	2	0	4	2	6	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr7:95775995T>A	uc003uof.3	-	14	1516	c.1325A>T	c.(1324-1326)CAG>CTG	p.Q442L	SLC25A13_uc003uog.3_Missense_Mutation_p.Q443L|SLC25A13_uc011kik.1_Missense_Mutation_p.Q334L	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	442	Solcar 2.|Helical; Name=3; (Potential).				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	GAAAATCACCTGGGAGCCTCC	0.433													63	73					0	0	0	0	A	95775995	A	A	95775995	3	1	218	1	0	0	0	0	1	0	0	0	14539	1580	55	5	722	5	SLC25A13	7	95775995	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	51196590	95775995	63362668	54	40032											
MYOM2	9172	broad.mit.edu	37	chr8	2040177	2040177	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtctcctacgaaaagttgTcccttctgctccgggtcggg	5	13	11	12	3	2	0	0	0	2	0	6	1	4	0	3	2	2	2	3	2	3	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:2040177T>C	uc003wpx.3	+	16	1970	c.1832T>C	c.(1831-1833)GTC>GCC	p.V611A	MYOM2_uc011kwi.1_Missense_Mutation_p.V36A	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	611					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CGAAAAGTTGTCCCTTCTGCT	0.557													103	144					0	0	0	0	C	2040177	C	C	2040177	3	2	218	1	0	0	0	0	1	0	0	0	10145	1667	58	5	1890	5	MYOM2	8	2040177	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08		2040177	144323845	55	40033											
PRSS55	203074	broad.mit.edu	37	chr8	10388887	10388887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaggtcgccagcatcattCttcacaaagactttaagaga	14	9	9	9	1	3	2	2	0	1	2	4	4	3	3	1	2	1	1	1	2	2	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:10388887C>T	uc003wta.2	+	3	445	c.430C>T	c.(430-432)CTT>TTT	p.L144F	uc010lru.2_Intron|PRSS55_uc003wtb.2_RNA	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	hypothetical protein LOC203074 precursor	144	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			ovary(1)	1						CAGCATCATTCTTCACAAAGA	0.517													34	155					0	0	0	0	T	10388887	T	T	10388887	3	4	218	1	0	0	0	0	1	0	0	0	12696	913	32	2	440	2	PRSS55	8	10388887	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	8348710	10388887	135975135	56	40034											
WRN	7486	broad.mit.edu	37	chr8	30977842	30977842	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattacggtgctcctaaggaCatggaatcatattatcagga	13	11	9	8	1	2	0	2	0	0	0	3	3	3	3	1	4	2	1	1	4	5	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:30977842C>A	uc003xio.3	+	21	3320	c.2532C>A	c.(2530-2532)GAC>GAA	p.D844E	WRN_uc010lvk.2_Missense_Mutation_p.D311E	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	844	Helicase C-terminal.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CTCCTAAGGACATGGAATCAT	0.423			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				31	72					8.16721e-17	1.72708e-16	1	0	A	30977842	A	A	30977842	3	1	218	1	0	0	0	0	1	0	0	0	17470	477	17	4	2610	4	WRN	8	30977842	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	20588955	30977842	115386180	57	40035											
ARFGEF1	10565	broad.mit.edu	37	chr8	68150679	68150679	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaatgtatcgaggtttcactCcagttcctataagctgtgcc	10	13	8	10	1	1	0	1	0	0	0	4	1	3	0	3	1	2	4	3	1	4	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:68150679C>G	uc003xxo.1	-	22	3578	c.3188G>C	c.(3187-3189)GGA>GCA	p.G1063A	ARFGEF1_uc003xxl.1_Missense_Mutation_p.G517A|ARFGEF1_uc003xxn.1_Missense_Mutation_p.G46A	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1063					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AGGTTTCACTCCAGTTCCTAT	0.393													18	37					0	0	0	0	G	68150679	G	G	68150679	3	3	218	1	0	0	0	0	1	0	0	0	852	855	30	2	2433	2	ARFGEF1	8	68150679	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	37172837	68150679	78213343	58	40036											
KCNB2	9312	broad.mit.edu	37	chr8	73850088	73850088	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtggactccagcccaaattGctttgcagataagcctagtg	10	10	11	10	0	0	1	0	0	0	1	1	2	1	2	3	2	4	2	3	2	3	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:73850088G>C	uc003xzb.2	+	3	3086	c.2498G>C	c.(2497-2499)TGC>TCC	p.C833S		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	833	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGCCCAAATTGCTTTGCAGAT	0.537													21	51					0	0	0	0	C	73850088	C	C	73850088	3	2	218	1	0	0	0	0	1	0	0	0	8052	1319	46	4	2504	4	KCNB2	8	73850088	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	5699409	73850088	72513934	59	40037											
ZFHX4	79776	broad.mit.edu	37	chr8	77767248	77767248	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaaagccacattcgctctcgGcactggaatgaaggaaagca	14	6	11	10	2	1	1	0	1	1	0	3	4	1	3	1	3	2	3	1	3	4	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:77767248G>A	uc003yav.2	+	10	8343	c.7956G>A	c.(7954-7956)CGG>CGA	p.R2652R	ZFHX4_uc003yau.1_Silent_p.R2697R|ZFHX4_uc003yaw.1_Silent_p.R2652R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2652	C2H2-type 17.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTCGCTCTCGGCACTGGAATG	0.512										HNSCC(33;0.089)			17	60					0	0	0	0	A	77767248	A	A	77767248	2	1	218	1	0	0	0	0	0	0	0	1	17702	1190	42	4		4	ZFHX4	8	77767248	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	3917160	77767248	68596774	60	40038											
OSGIN2	734	broad.mit.edu	37	chr8	90926441	90926441	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catctttccattgttgatcaGgtattatttcttacatgtca	9	19	5	8	0	4	1	2	1	2	0	5	1	5	1	1	1	1	2	1	1	3	7			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:90926441G>A	uc003yeg.2	+	3	550	c.204G>A	c.(202-204)CAG>CAA	p.Q68Q	OSGIN2_uc003yeh.2_Silent_p.Q112Q	NM_004337	NP_004328	Q9Y236	OSGI2_HUMAN	oxidative stress induced growth inhibitor family	68					germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TTGTTGATCAGGTATTATTTC	0.274													9	29					0	0	0	0	A	90926441	A	A	90926441	2	1	218	1	0	0	0	0	0	0	0	1	11344	1014	35	4		4	OSGIN2	8	90926441	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	13159193	90926441	55437581	61	40039											
RNF19A	25897	broad.mit.edu	37	chr8	101299760	101299760	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctggacaccacctacaatCaggatctgcaacaagccacc	14	5	7	15	0	2	0	1	0	1	0	2	2	2	2	4	2	5	2	4	2	4	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:101299760C>T	uc003yjj.1	-	3	960	c.643G>A	c.(643-645)GAT>AAT	p.D215N	RNF19A_uc003yjk.1_Missense_Mutation_p.D215N|RNF19A_uc003yjl.1_Missense_Mutation_p.D215N	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	215	IBR-type.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			CACCTACAATCAGGATCTGCA	0.358													28	59					0	0	0	0	T	101299760	T	T	101299760	3	4	218	1	0	0	0	0	1	0	0	0	13535	826	29	2	1909	2	RNF19A	8	101299760	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	10373319	101299760	45064262	62	40040											
LRP12	29967	broad.mit.edu	37	chr8	105503080	105503081	+	Frame_Shift_Ins	INS	-	TGAG	TGAG																															ctaagcccttgtccttgatcINStgaggcaagatcaagaagag																										TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:105503080_105503081insTGAG	uc003yma.2	-	7	2495_2496	c.2400_2401insCTCA	c.(2398-2403)TCAGATfs	p.S800fs	LRP12_uc003ymb.2_Frame_Shift_Ins_p.S781fs|LRP12_uc003ylz.2_Frame_Shift_Ins_p.S206fs	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	800_801	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGTCCTTGATCTGAGGCAAGAT	0.441													---	---	---								TGAG	105503081	TGAG	TGAG	105503080	7	5	218	1	0	1	1	0	0	0	0	0	9004	913	32	0	182	0	LRP12	8	105503080	Frame_Shift_Ins	INS	-	TCGA-CV-7091-01A-11D-2012-08	4203320	105503080	40860942	63	40041											
CSMD3	114788	broad.mit.edu	37	chr8	113259327	113259328	+	Frame_Shift_Ins	INS	-	T	T																															gacccttggagaaggtgtccINSttttttgcaatggaactgta																								rs142018478		TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:113259327_113259328insT	uc003ynu.2	-	64	10302_10303	c.10143_10144insA	c.(10141-10146)AAAGGAfs	p.K3381fs	CSMD3_uc003yns.2_Frame_Shift_Ins_p.K2583fs|CSMD3_uc003ynt.2_Frame_Shift_Ins_p.K3341fs|CSMD3_uc011lhx.1_Frame_Shift_Ins_p.K3212fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3381_3382	Extracellular (Potential).|Sushi 27.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGAAGGTGTCCTTTTTTGCAAT	0.406										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---								T	113259328	T	T	113259327	7	5	218	1	0	1	1	0	0	0	0	0	3963	690	24	0	1011	0	CSMD3	8	113259327	Frame_Shift_Ins	INS	-	TCGA-CV-7091-01A-11D-2012-08	7756247	113259327	33104695	64	40042											
CSMD3	114788	broad.mit.edu	37	chr8	113267646	113267646	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggtataccagggtcaccAcaaaactttgctggaaatga	14	8	10	9	0	1	1	1	1	0	0	1	2	1	2	2	3	3	3	2	3	5	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:113267646A>T	uc003ynu.2	-	62	10032	c.9873T>A	c.(9871-9873)TGT>TGA	p.C3291*	CSMD3_uc003yns.2_Nonsense_Mutation_p.C2493*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.C3251*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.C3122*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3291	Extracellular (Potential).|Sushi 26.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CAGGGTCACCACAAAACTTTG	0.363										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	52					0	0	0	0	T	113267646	T	T	113267646	4	4	218	1	0	0	0	0	0	1	0	0	3963	157	6	5	1290	5	CSMD3	8	113267646	Nonsense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	8319	113267646	33096376	65	40043											
TRPS1	7227	broad.mit.edu	37	chr8	116631670	116631670	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgggtctgggttgtcattcaCcagtaagtcagttttggatt	7	15	12	7	1	4	0	3	0	1	0	4	1	4	1	1	3	0	3	1	3	1	6			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:116631670C>T	uc003ynz.2	-	2	1075	c.616G>A	c.(616-618)GTG>ATG	p.V206M	TRPS1_uc011lhy.1_Missense_Mutation_p.V210M|TRPS1_uc003yny.2_Missense_Mutation_p.V219M|TRPS1_uc010mcy.2_Missense_Mutation_p.V206M	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	206					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTGTCATTCACCAGTAAGTCA	0.468									Langer-Giedion_syndrome				29	121					0	0	0	0	T	116631670	T	T	116631670	3	4	218	1	0	0	0	0	1	0	0	0	16660	507	18	4	3249	4	TRPS1	8	116631670	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	3364024	116631670	29732352	66	40044											
COL22A1	169044	broad.mit.edu	37	chr8	139642988	139642988	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agctcctgcaattccatctgCcccctaaaaaagacaaggca	14	7	6	14	0	1	1	0	0	1	1	3	1	3	1	4	1	3	3	4	1	5	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr8:139642988C>A	uc003yvd.2	-	50	4060	c.3613G>T	c.(3613-3615)GCA>TCA	p.A1205S	COL22A1_uc011ljo.1_Missense_Mutation_p.A485S	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1205	Pro-rich.|Gly-rich.|Collagen-like 11.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ATTCCATCTGCCCCCTAAAAA	0.418										HNSCC(7;0.00092)			35	109					4.90274e-10	9.98595e-10	1	0	A	139642988	A	A	139642988	3	1	218	1	0	0	0	0	1	0	0	0	3696	739	26	4	1331	4	COL22A1	8	139642988	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	23011318	139642988	6721034	67	40045											
PIP5K1B	8395	broad.mit.edu	37	chr9	71555671	71555671	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttatacgtcaatgagcaCtatccacacgacaggcctac	12	9	6	14	2	1	1	1	1	0	0	3	2	3	1	3	1	3	1	3	1	5	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr9:71555671C>G	uc004agu.2	+	14	1772	c.1467C>G	c.(1465-1467)CAC>CAG	p.H489Q	PIP5K1B_uc011lrq.1_Missense_Mutation_p.H489Q|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	489						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		TCAATGAGCACTATCCACACG	0.478													33	56					0	0	0	0	G	71555671	G	G	71555671	3	3	218	1	0	0	0	0	1	0	0	0	11995	564	20	4	1509	4	PIP5K1B	9	71555671	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08		71555671	69657760	68	40046											
TEX10	54881	broad.mit.edu	37	chr9	103090242	103090242	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggataacactttactacgaTatcttagaaaggccaaagaa	17	9	8	7	1	1	2	0	0	1	2	1	4	1	3	1	2	3	0	1	2	8	6			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr9:103090242T>C	uc004bas.2	-	8	1843	c.1628A>G	c.(1627-1629)TAT>TGT	p.Y543C	TEX10_uc011lvf.1_Missense_Mutation_p.Y382C|TEX10_uc011lvg.1_Missense_Mutation_p.Y546C	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	543						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TTTACTACGATATCTTAGAAA	0.328													4	9					0	0	0	0	C	103090242	C	C	103090242	3	2	218	1	0	0	0	0	1	0	0	0	15838	1406	49	5	1193	5	TEX10	9	103090242	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	31534571	103090242	38123189	69	40047											
LHX6	26468	broad.mit.edu	37	chr9	124989225	124989225	+	Frame_Shift_Del	DEL	C	-	-																															ggcagagggcggtgagcagaCagatggcgtgctgggcgtac																										TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr9:124989225delC	uc010mvw.2	-	2	263	c.154delG	c.(154-156)GTCfs	p.V52fs	LHX6_uc004blx.3_Frame_Shift_Del_p.V81fs|LHX6_uc004bly.3_Frame_Shift_Del_p.V81fs	NM_014368	NP_055183	Q9UPM6	LHX6_HUMAN	LIM homeobox protein 6 isoform 1	52					cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGTGAGCAGACAGATGGCGTG	0.662													---	---	---								-	124989225	-	-	124989225	7	5	218	1	0	1	0	1	0	0	0	0	8816	478	17	0	1028	0	LHX6	9	124989225	Frame_Shift_Del	DEL	C	TCGA-CV-7091-01A-11D-2012-08	21898983	124989225	16224206	70	40048											
TUBB2C	10383	broad.mit.edu	37	chr9	140137973	140137973	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacagccgaggaggagggcGagttcgaggaggaggctgag	10	3	20	8	3	0	1	0	1	0	0	1	8	0	5	2	6	1	2	2	6	0	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr9:140137973G>A	uc004cmh.1	+	4	1405	c.1303G>A	c.(1303-1305)GAG>AAG	p.E435K	TUBB2C_uc004cmg.1_Missense_Mutation_p.E289K	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	435					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GGAGGAGGGCGAGTTCGAGGA	0.587													48	45					0	0	0	0	A	140137973	A	A	140137973	3	1	218	1	0	0	0	0	1	0	0	0	16824	1059	37	1	1317	1	TUBB2C	9	140137973	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	15148748	140137973	1075458	71	40049											
SVIL	6840	broad.mit.edu	37	chr10	29824982	29824982	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttctggagaaaccactcatGtttgggtttccctgtactat	8	16	8	9	0	2	1	1	0	1	1	3	2	3	1	2	2	2	3	2	2	3	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr10:29824982G>C	uc001iut.1	-	7	1597	c.844C>G	c.(844-846)CAT>GAT	p.H282D	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_Missense_Mutation_p.H282D	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	282					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AACCACTCATGTTTGGGTTTC	0.433											OREG0020098	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	49					0	0	0	0	C	29824982	C	C	29824982	3	2	218	1	0	0	0	0	1	0	0	0	15487	1377	48	4	5928	4	SVIL	10	29824982	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08		29824982	105709765	72	40050											
BLNK	29760	broad.mit.edu	37	chr10	97976475	97976475	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttcatcattatcttccacggGgaccacataatcagcctaac	12	11	5	13	1	4	0	3	0	1	0	5	1	5	1	3	2	2	0	3	2	3	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr10:97976475G>T	uc001kls.3	-	7	719	c.541C>A	c.(541-543)CCC>ACC	p.P181T	BLNK_uc001kme.3_Missense_Mutation_p.P99T|BLNK_uc001klt.3_Missense_Mutation_p.P95T|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Missense_Mutation_p.P99T|BLNK_uc001klv.3_Intron|BLNK_uc001klw.3_RNA|BLNK_uc001klx.3_Missense_Mutation_p.P181T|BLNK_uc001kly.3_Missense_Mutation_p.P181T|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Missense_Mutation_p.P181T|BLNK_uc001kmb.3_5'UTR|BLNK_uc001kmc.3_RNA|BLNK_uc001kmd.3_Missense_Mutation_p.P99T|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	181	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		TCTTCCACGGGGACCACATAA	0.368													8	27					0.000157383	0.000303786	1	0	T	97976475	T	T	97976475	3	4	218	1	0	0	0	0	1	0	0	0	1450	1232	43	4	873	4	BLNK	10	97976475	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	68151493	97976475	37558272	73	40051											
SEMA4G	57715	broad.mit.edu	37	chr10	102740948	102740948	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcactgatacaggacatagAgagaggaaatcgaggctgtg	15	6	14	6	1	0	3	0	1	0	2	1	7	0	5	0	3	2	2	0	3	3	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr10:102740948A>G	uc001krw.1	+	13	2051	c.1667A>G	c.(1666-1668)GAG>GGG	p.E556G	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krx.2_Missense_Mutation_p.E556G|MRPL43_uc001kry.1_Intron|MRPL43_uc010qpu.1_Intron	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	551	Extracellular (Potential).|PSI.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		CAGGACATAGAGAGAGGAAAT	0.483													7	56					0	0	0	0	G	102740948	G	G	102740948	3	3	218	1	0	0	0	0	1	0	0	0	14101	304	11	5	1717	5	SEMA4G	10	102740948	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	4764473	102740948	32793799	74	40052											
KCNQ1	3784	broad.mit.edu	37	chr11	2594162	2594162	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgagaaggacgcggtgaaCgagtcaggccgcgtggagtt	9	6	18	8	5	1	2	1	2	0	1	1	6	1	4	1	4	1	2	1	4	2	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:2594162C>T	uc001lwn.2	+	6	975	c.867C>T	c.(865-867)AAC>AAT	p.N289N	KCNQ1_uc009ydp.1_Silent_p.N73N|KCNQ1_uc001lwo.2_Silent_p.N162N	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	289	Extracellular (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	ACGCGGTGAACGAGTCAGGCC	0.597													15	19					0	0	0	0	T	2594162	T	T	2594162	2	4	218	1	0	0	0	0	0	0	0	1	8121	535	19	1		1	KCNQ1	11	2594162	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08		2594162	132412354	75	40053											
OR5M9	390162	broad.mit.edu	37	chr11	56230205	56230205	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccatcggcagagcgcatgcGtagcacagctactacaatga	12	6	11	12	3	0	2	0	1	0	1	1	2	0	2	1	1	6	5	1	1	4	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:56230205G>A	uc010rjj.1	-	1	673	c.673C>T	c.(673-675)CGC>TGC	p.R225C		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					GAGCGCATGCGTAGCACAGCT	0.478													7	10					0	0	0	0	A	56230205	A	A	56230205	3	1	218	1	0	0	0	0	1	0	0	0	11231	1145	40	1	261	1	OR5M9	11	56230205	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	53636043	56230205	78776311	76	40054											
MUS81	80198	broad.mit.edu	37	chr11	65631092	65631092	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcgggcacaggccggagctGctccgagagctacagcggct	7	4	17	13	4	0	1	0	0	0	1	1	3	1	2	2	5	5	5	2	5	1	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:65631092G>C	uc001ofv.3	+	9	1214	c.861G>C	c.(859-861)CTG>CTC	p.L287L	MUS81_uc001ofw.3_RNA|MUS81_uc001ofx.3_5'UTR	NM_025128	NP_079404	Q96NY9	MUS81_HUMAN	MUS81 endonuclease homolog	287	ERCC4.				DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding				0				READ - Rectum adenocarcinoma(159;0.166)		GGCCGGAGCTGCTCCGAGAGC	0.632								Homologous_recombination					3	28					0	0	0	0	C	65631092	C	C	65631092	2	2	218	1	0	0	0	0	0	0	0	1	10041	1306	46	4		4	MUS81	11	65631092	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	9400887	65631092	69375424	77	40055											
DPP3	10072	broad.mit.edu	37	chr11	66262860	66262860	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agagctggtatcggagcgggGagacctgggatagcaagttc	10	7	17	7	2	0	2	0	0	0	2	2	5	0	4	1	5	3	4	1	5	3	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:66262860G>C	uc001oig.1	+	14	1539	c.1477G>C	c.(1477-1479)GAG>CAG	p.E493Q	DPP3_uc001oif.1_Missense_Mutation_p.E493Q|DPP3_uc010rpe.1_Missense_Mutation_p.E482Q|DPP3_uc001oih.1_5'Flank	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	493					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						TCGGAGCGGGGAGACCTGGGA	0.622													4	27					0	0	0	0	C	66262860	C	C	66262860	3	2	218	1	0	0	0	0	1	0	0	0	4750	1175	41	2	1527	2	DPP3	11	66262860	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	631768	66262860	68743656	78	40056											
ACTN3	89	broad.mit.edu	37	chr11	66326764	66326764	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctttgctacaggaggtgcGggcgttgctgcggcgccacg	4	8	18	11	5	0	0	0	0	0	0	0	1	0	1	1	5	5	4	1	5	1	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:66326764G>T	uc001oio.1	+	12	1352	c.1334G>T	c.(1333-1335)CGG>CTG	p.R445L	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	445	Spectrin 2.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						CAGGAGGTGCGGGCGTTGCTG	0.647													9	44					1.76689e-08	3.57688e-08	1	0	T	66326764	T	T	66326764	3	4	218	1	0	0	0	0	1	0	0	0	206	1116	39	3	1380	3	ACTN3	11	66326764	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	63904	66326764	68679752	79	40057											
PC	5091	broad.mit.edu	37	chr11	66617734	66617734	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggttggcctccacataggccTtcttgacctccttgaacttg	6	13	9	13	0	1	2	0	2	1	0	3	2	3	2	5	3	1	1	5	3	2	6			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:66617734T>C	uc001ojn.1	-	17	2724	c.2675A>G	c.(2674-2676)AAG>AGG	p.K892R	PC_uc001ojo.1_Missense_Mutation_p.K892R|PC_uc001ojp.1_Missense_Mutation_p.K892R|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	892					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CACATAGGCCTTCTTGACCTC	0.602													11	41					0	0	0	0	C	66617734	C	C	66617734	3	2	218	1	0	0	0	0	1	0	0	0	11551	1609	56	5	881	5	PC	11	66617734	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	290970	66617734	68388782	80	40058											
CHKA	1119	broad.mit.edu	37	chr11	67821473	67821473	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtcacaccccaagcttcctCttctggtggaaataggcatc	10	10	8	13	0	3	0	1	0	2	0	5	1	4	1	3	3	1	2	3	3	3	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:67821473C>T	uc001onj.2	-	12	1570	c.1356G>A	c.(1354-1356)AAG>AAA	p.K452K	CHKA_uc001onk.2_Silent_p.K434K	NM_001277	NP_001268	P35790	CHKA_HUMAN	choline kinase alpha isoform a	452					lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2					Choline(DB00122)	CAAGCTTCCTCTTCTGGTGGA	0.577													5	16					0	0	0	0	T	67821473	T	T	67821473	2	4	218	1	0	0	0	0	0	0	0	1	3362	912	32	2		2	CHKA	11	67821473	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08	1203739	67821473	67185043	81	40059											
VPS11	55823	broad.mit.edu	37	chr11	118938701	118938701	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactgtctgcgactcaggccGagggagcctggtctttggag	6	9	15	11	2	3	0	1	0	2	0	3	4	3	2	2	4	2	0	2	4	0	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr11:118938701G>A	uc010ryx.1	+	1	209	c.167G>A	c.(166-168)CGA>CAA	p.R56Q	VPS11_uc010ryy.1_5'UTR	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	56					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GACTCAGGCCGAGGGAGCCTG	0.577													4	10					0	0	0	0	A	118938701	A	A	118938701	3	1	218	1	0	0	0	0	1	0	0	0	17256	1058	37	1	169	1	VPS11	11	118938701	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	51117228	118938701	16067815	82	40060											
ERC1	23085	broad.mit.edu	37	chr12	1289706	1289706	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatatttatgtacatttagAttgaaaatcttcaagagcag	17	14	6	4	0	2	3	1	1	1	2	2	3	2	3	0	0	2	2	0	0	8	8			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:1289706A>C	uc001qjb.2	+	9	1979	c.1738A>C	c.(1738-1740)ATT>CTT	p.I580L	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.I552L|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Missense_Mutation_p.I580L|ERC1_uc010sdv.1_Missense_Mutation_p.I328L|ERC1_uc009zdp.2_Missense_Mutation_p.I220L	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	580	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GTACATTTAGATTGAAAATCT	0.368													17	32					0	0	0	0	C	1289706	C	C	1289706	3	2	218	1	0	0	0	0	1	0	0	0	5234	347	12	5	1768	5	ERC1	12	1289706	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08		1289706	132562189	83	40061											
GDF3	9573	broad.mit.edu	37	chr12	7843292	7843292	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaattttctttgggtaaaGaaagaaacctagatgggaaa	17	10	11	3	0	1	3	0	0	1	3	1	5	1	5	1	3	1	1	1	3	7	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:7843292G>T	uc001qte.2	-	2	313	c.277C>A	c.(277-279)CTT>ATT	p.L93I		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	93					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						TTTGGGTAAAGAAAGAAACCT	0.403													28	56					4.87955e-14	1.01251e-13	1	0	T	7843292	T	T	7843292	3	4	218	1	0	0	0	0	1	0	0	0	6352	942	33	2	821	2	GDF3	12	7843292	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	6553586	7843292	126008603	84	40062											
SLCO1C1	53919	broad.mit.edu	37	chr12	20876088	20876088	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcctatatttatgtacaagCactgttcagttcaattctct	10	18	4	9	0	3	0	2	0	1	0	5	0	4	0	1	0	2	4	1	0	6	9			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:20876088C>A	uc001rej.3	+	10	1441	c.1086C>A	c.(1084-1086)AGC>AGA	p.S362R	SLCO1C1_uc010sii.1_Missense_Mutation_p.S362R|SLCO1C1_uc010sij.1_Missense_Mutation_p.S313R|SLCO1C1_uc009zip.2_Missense_Mutation_p.S196R|SLCO1C1_uc001rei.2_Missense_Mutation_p.S362R|SLCO1C1_uc010sik.1_Missense_Mutation_p.S244R	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	362	Helical; Name=7; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TATGTACAAGCACTGTTCAGT	0.378													28	71					4.87955e-14	1.01251e-13	1	0	A	20876088	A	A	20876088	3	1	218	1	0	0	0	0	1	0	0	0	14789	709	25	4	1116	4	SLCO1C1	12	20876088	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	13032796	20876088	112975807	85	40063											
SLC38A1	81539	broad.mit.edu	37	chr12	46592498	46592498	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgtcatctttactctgataTttgtgaaggaggtcggactg	9	15	11	6	1	3	2	1	2	2	0	4	4	3	4	0	3	1	0	0	3	3	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:46592498T>C	uc001rpa.2	-	14	1290	c.1032A>G	c.(1030-1032)AAA>AAG	p.K344K	SLC38A1_uc001rpb.2_Silent_p.K344K|SLC38A1_uc001rpc.2_Silent_p.K344K|SLC38A1_uc001rpd.2_Silent_p.K344K|SLC38A1_uc001rpe.2_Silent_p.K344K|SLC38A1_uc009zkj.1_Silent_p.K344K	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	344	Extracellular (Potential).				cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			TACTCTGATATTTGTGAAGGA	0.428													16	42					0	0	0	0	C	46592498	C	C	46592498	2	2	218	1	0	0	0	0	0	0	0	1	14665	1490	52	5		5	SLC38A1	12	46592498	Silent	SNP	T	TCGA-CV-7091-01A-11D-2012-08	25716410	46592498	87259397	86	40064											
SCN8A	6334	broad.mit.edu	37	chr12	52200796	52200796	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atggtgagcggggatcgcatCcactgcttggacatcctttt	7	12	12	10	2	0	1	0	1	0	0	3	3	2	3	2	4	2	2	2	4	0	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:52200796C>A	uc001ryw.2	+	27	5704	c.5526C>A	c.(5524-5526)ATC>ATA	p.I1842I	uc001rzb.1_5'Flank	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1842					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GGGATCGCATCCACTGCTTGG	0.567													43	110					7.63091e-17	1.62401e-16	1	0	A	52200796	A	A	52200796	2	1	218	1	0	0	0	0	0	0	0	1	13989	845	30	2		2	SCN8A	12	52200796	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08	5608298	52200796	81651099	87	40065											
CALCOCO1	57658	broad.mit.edu	37	chr12	54106918	54106918	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaaggcactgcccagttcagGaagcagtaagttggcctcct	10	8	12	11	0	1	0	1	0	0	0	2	2	2	1	3	3	2	5	3	3	3	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:54106918G>C	uc001sef.2	-	14	2008	c.1864C>G	c.(1864-1866)CCT>GCT	p.P622A	CALCOCO1_uc001see.2_Missense_Mutation_p.P123A|CALCOCO1_uc010som.1_Missense_Mutation_p.P537A|CALCOCO1_uc010son.1_Missense_Mutation_p.P499A|CALCOCO1_uc001seh.2_Missense_Mutation_p.P622A|CALCOCO1_uc009znd.2_Missense_Mutation_p.P621A|CALCOCO1_uc001seg.2_Missense_Mutation_p.P447A	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	622	C-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CCCAGTTCAGGAAGCAGTAAG	0.577													31	69					0	0	0	0	C	54106918	C	C	54106918	3	2	218	1	0	0	0	0	1	0	0	0	2589	1174	41	2	219	2	CALCOCO1	12	54106918	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	1906122	54106918	79744977	88	40066											
OR6C70	390327	broad.mit.edu	37	chr12	55863389	55863389	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgtaggataagagaaatGtcacaaatgaaatgatcaat	19	10	9	3	0	2	3	2	2	0	1	2	5	2	4	0	1	0	2	0	1	6	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:55863389G>A	uc010spn.1	-	1	534	c.534C>T	c.(532-534)GAC>GAT	p.D178D		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TAAGAGAAATGTCACAAATGA	0.348													32	94					0	0	0	0	A	55863389	A	A	55863389	2	1	218	1	0	0	0	0	0	0	0	1	11251	1368	48	4		4	OR6C70	12	55863389	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	1756471	55863389	77988506	89	40067											
LRP1	4035	broad.mit.edu	37	chr12	57592066	57592066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcaatggggcctatcggaCggtgctggtcagctctggcc	5	9	15	12	2	3	0	2	0	1	0	4	1	3	1	2	6	2	3	2	6	2	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:57592066C>T	uc001snd.2	+	59	9876	c.9410C>T	c.(9409-9411)ACG>ATG	p.T3137M		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3137	LDL-receptor class B 27.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCCTATCGGACGGTGCTGGTC	0.637													11	32					0	0	0	0	T	57592066	T	T	57592066	3	4	218	1	0	0	0	0	1	0	0	0	9001	536	19	1	9644	1	LRP1	12	57592066	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	1728677	57592066	76259829	90	40068											
CPSF6	11052	broad.mit.edu	37	chr12	69656338	69656338	+	Nonstop_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcgcgaatatcgtcatcgttAgaaggtgggtattccttgtt	8	14	12	7	4	1	1	1	0	0	1	4	2	2	1	1	2	0	3	1	2	5	6			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:69656338A>G	uc001sut.3	+	9	1765	c.1655A>G	c.(1654-1656)TAG>TGG	p.*552W	CPSF6_uc001suu.3_Nonstop_Mutation_p.*589W|CPSF6_uc010stk.1_Nonstop_Mutation_p.*184W	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	552					mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			CGTCATCGTTAGAAGGTGGGT	0.313													6	33					0	0	0	0	G	69656338	G	G	69656338	4	3	218	1	0	0	0	0	0	0	0	0	3844	433	15	5	1689	5	CPSF6	12	69656338	Nonstop_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	12064272	69656338	64195557	91	40069											
VEZT	55591	broad.mit.edu	37	chr12	95694417	95694417	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaggaagaacaaataataGaagaaaataaaaatgagata	26	5	9	1	0	0	4	0	1	0	4	0	7	0	6	0	2	1	0	0	2	12	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:95694417G>C	uc001tdz.2	+	12	2413	c.2308G>C	c.(2308-2310)GAA>CAA	p.E770Q	VEZT_uc009ztb.1_RNA|VEZT_uc009ztc.1_Missense_Mutation_p.E135Q|VEZT_uc001tdy.2_RNA	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	770						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						ACAAATAATAGAAGAAAATAA	0.383													3	32					0	0	0	0	C	95694417	C	C	95694417	3	2	218	1	0	0	0	0	1	0	0	0	17224	943	33	2	2354	2	VEZT	12	95694417	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	26038079	95694417	38157478	92	40070											
NAA25	80018	broad.mit.edu	37	chr12	112518864	112518864	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attctgaatgccatactcacTtgcataattaagctcatcac	13	13	4	11	0	4	1	3	1	1	0	4	1	4	1	1	0	4	2	1	0	4	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:112518864T>G	uc001ttm.2	-	5	497	c.477A>C	c.(475-477)CAA>CAC	p.Q159H	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.Q131H|NAA25_uc009zwa.1_Missense_Mutation_p.Q159H	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	159						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						CCATACTCACTTGCATAATTA	0.323													35	157					0	0	0	0	G	112518864	G	G	112518864	3	3	218	1	0	0	0	0	1	0	0	0	10174	1623	56	5	2521	5	NAA25	12	112518864	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	16824447	112518864	21333031	93	40071											
UBC	7316	broad.mit.edu	37	chr12	125397805	125397805	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acattctcgatggtgtcactGggctccacctcgagggtgat	7	11	12	11	2	2	1	1	1	1	0	5	3	3	1	2	3	0	1	2	3	0	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr12:125397805G>C	uc001ugs.3	-	2	961	c.513C>G	c.(511-513)CCC>CCG	p.P171P	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Silent_p.P171P|UBC_uc001ugt.2_Silent_p.P171P|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Silent_p.P19P	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	171	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGGTGTCACTGGGCTCCACCT	0.517													4	84					0	0	0	0	C	125397805	C	C	125397805	2	2	218	1	0	0	0	0	0	0	0	1	16910	1335	47	4		4	UBC	12	125397805	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	12878941	125397805	8454090	94	40072											
LCP1	3936	broad.mit.edu	37	chr13	46716545	46716545	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttccccaattctaccgcgtAgttacaattctcaagctgaa	11	12	5	13	2	2	1	1	1	2	0	4	1	3	1	3	0	3	3	3	0	7	6			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr13:46716545A>C	uc001vaz.3	-	13	1510	c.1384T>G	c.(1384-1386)TAC>GAC	p.Y462D	LCP1_uc010ack.2_Missense_Mutation_p.Y31D|LCP1_uc001vay.3_Missense_Mutation_p.Y59D|LCP1_uc001vba.3_Missense_Mutation_p.Y462D	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	462	Actin-binding 2.|CH 3.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TCTACCGCGTAGTTACAATTC	0.373			T	BCL6	NHL 								10	28					0	0	0	0	C	46716545	C	C	46716545	3	2	218	1	0	0	0	0	1	0	0	0	8731	420	15	5	515	5	LCP1	13	46716545	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08		46716545	68453333	95	40073											
KLHL1	57626	broad.mit.edu	37	chr13	70535472	70535472	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attggacaaggtcccagagaGcattggggtctatgccttcc	9	10	12	10	0	1	1	0	0	1	1	3	3	3	2	3	4	2	1	3	4	2	4	rs139916031		TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr13:70535472G>A	uc001vip.2	-	3	1579	c.785C>T	c.(784-786)GCT>GTT	p.A262V	KLHL1_uc010thm.1_Missense_Mutation_p.A201V	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	262	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GTCCCAGAGAGCATTGGGGTC	0.388													18	33					0	0	0	0	A	70535472	A	A	70535472	3	1	218	1	0	0	0	0	1	0	0	0	8404	971	34	4	1497	4	KLHL1	13	70535472	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	23818927	70535472	44634406	96	40074											
MYCBP2	23077	broad.mit.edu	37	chr13	77742684	77742684	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttcctgtggtgctatctgtcGactgattagggttgaaggca	7	14	13	7	1	1	2	0	2	1	0	3	3	2	2	1	3	1	3	1	3	3	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr13:77742684G>C	uc001vkf.2	-	41	5970	c.5879C>G	c.(5878-5880)TCG>TGG	p.S1960W	MYCBP2_uc010aev.2_Missense_Mutation_p.S1364W	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1960					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GCTATCTGTCGACTGATTAGG	0.493													18	72					0	0	0	0	C	77742684	C	C	77742684	3	2	218	1	0	0	0	0	1	0	0	0	10071	1059	37	3	8219	3	MYCBP2	13	77742684	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	7207212	77742684	37427194	97	40075											
CTAGE5	4253	broad.mit.edu	37	chr14	39769088	39769088	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttttgcaagaagctgaagtAtggaaagaacaagtgagtga	16	9	12	4	0	0	5	0	3	0	2	0	6	0	6	0	1	3	3	0	1	7	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr14:39769088A>T	uc001wvg.3	+	9	1029	c.693A>T	c.(691-693)GTA>GTT	p.V231V	CTAGE5_uc010tqe.1_Silent_p.V193V|CTAGE5_uc001wuz.3_Silent_p.V219V|CTAGE5_uc001wuy.3_Silent_p.V151V|CTAGE5_uc001wvb.3_Silent_p.V202V|CTAGE5_uc001wvc.3_Silent_p.V176V|CTAGE5_uc001wva.3_Silent_p.V202V|CTAGE5_uc001wve.1_Silent_p.V207V|CTAGE5_uc001wvh.3_Silent_p.V231V|CTAGE5_uc001wvf.3_Silent_p.V156V|CTAGE5_uc001wvi.3_Silent_p.V236V|CTAGE5_uc010amz.2_5'UTR|CTAGE5_uc001wvj.3_Silent_p.V202V	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	231	Potential.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		AAGCTGAAGTATGGAAAGAAC	0.318													8	75					0	0	0	0	T	39769088	T	T	39769088	2	4	218	1	0	0	0	0	0	0	0	1	4011	436	16	5		5	CTAGE5	14	39769088	Silent	SNP	A	TCGA-CV-7091-01A-11D-2012-08		39769088	67580452	98	40076											
PRKCH	5583	broad.mit.edu	37	chr14	61997130	61997130	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccccctttgcacagatcctCcaggaaatgctgtacgggcc	8	8	10	15	1	0	1	0	0	0	1	2	2	2	2	5	2	3	3	5	2	2	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr14:61997130C>A	uc001xfn.2	+	12	1883	c.1578C>A	c.(1576-1578)CTC>CTA	p.L526L	PRKCH_uc010tsa.1_Silent_p.L365L|PRKCH_uc010tsb.1_Silent_p.L94L	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	526	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		CACAGATCCTCCAGGAAATGC	0.483													30	138					3.99451e-17	8.55598e-17	1	0	A	61997130	A	A	61997130	2	1	218	1	0	0	0	0	0	0	0	1	12575	842	30	2		2	PRKCH	14	61997130	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08	22228042	61997130	45352410	99	40077											
SYT16	83851	broad.mit.edu	37	chr14	62541956	62541957	+	Frame_Shift_Ins	INS	-	A	A																															catgtgaaagaggggatgccINSaaacaccacggcacatctca																										TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr14:62541956_62541957insA	uc001xfu.1	+	3	1037_1038	c.840_841insA	c.(838-843)GCCAAAfs	p.A280fs	SYT16_uc010tsd.1_Frame_Shift_Ins_p.A280fs	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	280_281										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GAGGGGATGCCAAACACCACGG	0.545													---	---	---								A	62541957	A	A	62541956	7	5	218	1	0	1	1	0	0	0	0	0	15538	581	21	0	850	0	SYT16	14	62541956	Frame_Shift_Ins	INS	-	TCGA-CV-7091-01A-11D-2012-08	544826	62541956	44807584	100	40078											
RGS6	9628	broad.mit.edu	37	chr14	72925015	72925015	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggagccttatcgctgcccAgggctacatctttccaatct	7	11	10	13	1	2	0	0	0	2	0	4	1	3	1	3	3	3	2	3	3	3	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr14:72925015A>C	uc001xna.3	+	5	795	c.272A>C	c.(271-273)CAG>CCG	p.Q91P	RGS6_uc010ttn.1_Missense_Mutation_p.Q91P|RGS6_uc001xmx.3_Missense_Mutation_p.Q91P|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.Q91P|RGS6_uc010ttp.1_Missense_Mutation_p.Q22P|RGS6_uc001xmz.1_5'Flank|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	91	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		ATCGCTGCCCAGGGCTACATC	0.458													26	53					0	0	0	0	C	72925015	C	C	72925015	3	2	218	1	0	0	0	0	1	0	0	0	13374	188	7	5	286	5	RGS6	14	72925015	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	10383059	72925015	34424525	101	40079											
TECPR2	9895	broad.mit.edu	37	chr14	102931608	102931608	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcttccagcctggataatGattgagccacctgtccaggt	9	11	10	11	0	0	2	0	2	0	0	2	3	2	3	5	2	3	1	5	2	1	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr14:102931608G>C	uc001ylw.1	+	17	3919	c.3771G>C	c.(3769-3771)ATG>ATC	p.M1257I	TECPR2_uc010awl.2_Missense_Mutation_p.M1257I|TECPR2_uc010txx.1_Missense_Mutation_p.M420I	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1257	TECPR 4.						protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						CCTGGATAATGATTGAGCCAC	0.502													13	45					0	0	0	0	C	102931608	C	C	102931608	3	2	218	1	0	0	0	0	1	0	0	0	15810	1290	45	2	3833	2	TECPR2	14	102931608	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	30006593	102931608	4417932	102	40080											
RYR3	6263	broad.mit.edu	37	chr15	33955093	33955093	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctggggagaaggccggcaagGaggctcctgtcaaaggcttg	9	6	17	9	1	1	1	1	0	0	1	2	3	2	2	2	7	0	3	2	7	3	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr15:33955093G>T	uc001zhi.2	+	35	5432	c.5362G>T	c.(5362-5364)GAG>TAG	p.E1788*	RYR3_uc010bar.2_Nonsense_Mutation_p.E1788*	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1788	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGCCGGCAAGGAGGCTCCTGT	0.562													29	179					1.30897e-18	2.84038e-18	1	0	T	33955093	T	T	33955093	4	4	218	1	0	0	0	0	0	1	0	0	13835	1175	41	2	5500	2	RYR3	15	33955093	Nonsense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08		33955093	68576299	103	40081											
HERC1	8925	broad.mit.edu	37	chr15	63904544	63904544	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaacctcatgaaaagcaccCgctcctcattggagaactct	13	8	6	14	1	3	2	2	1	1	1	4	3	4	2	3	1	3	2	3	1	4	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr15:63904544C>T	uc002amp.2	-	77	14454	c.14306G>A	c.(14305-14307)CGG>CAG	p.R4769Q	HERC1_uc002amo.2_5'Flank	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4769	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GAAAAGCACCCGCTCCTCATT	0.493													6	44					0	0	0	0	T	63904544	T	T	63904544	3	4	218	1	0	0	0	0	1	0	0	0	7096	652	23	1	287	1	HERC1	15	63904544	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	29949451	63904544	38626848	104	40082											
ISL2	64843	broad.mit.edu	37	chr15	76629267	76629267	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atccttttctgggtgctatgGgtgatcattccaagagtaag	9	14	11	7	0	2	2	1	1	1	1	4	2	4	2	2	2	1	2	2	2	3	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr15:76629267G>A	uc002bbw.1	+	1	121	c.43G>A	c.(43-45)GGT>AGT	p.G15S		NM_145805	NP_665804	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	15						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGGTGCTATGGGTGATCATTC	0.443													52	330					0	0	0	0	A	76629267	A	A	76629267	3	1	218	1	0	0	0	0	1	0	0	0	7896	1232	43	4	45	4	ISL2	15	76629267	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	12724723	76629267	25902125	105	40083											
PRSS27	83886	broad.mit.edu	37	chr16	2762622	2762622	+	Nonstop_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcctggccccgggggtctCacttctggccgcccaacctc	3	8	11	19	2	2	0	1	0	2	0	5	0	3	0	6	4	1	1	6	4	1	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	68d635f1-65fb-4395-99c0-a34514289521	g.chr16:2762622C>G	uc002crf.2	-	6	1263	c.872G>C	c.(871-873)TGA>TCA	p.*291S	PRSS27_uc002cre.2_Nonstop_Mutation_p.*255S|PRSS27_uc002crg.2_Nonstop_Mutation_p.*189S	NM_031948	NP_114154	Q9BQR3	PRS27_HUMAN	marapsin precursor	291					proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						CCGGGGGTCTCACTTCTGGCC	0.652													2	3					0	0	0	0	G	2762622	G	G	2762622	4	3	218	1	0	0	0	0	0	0	0	0	12683	837	29	2	4	2	PRSS27	16	2762622	Nonstop_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08		2762622	87592131	106	40084											
SRRM2	23524	broad.mit.edu	37	chr16	2817671	2817671	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	attgtctggtgcaaacctcaCcagccccagggtgccccttt	7	10	9	15	0	2	0	1	0	1	0	2	0	2	0	6	2	4	1	6	2	1	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:2817671C>G	uc002crk.2	+	11	7691	c.7142C>G	c.(7141-7143)ACC>AGC	p.T2381S	SRRM2_uc002crj.1_Missense_Mutation_p.T2285S|SRRM2_uc002crl.1_Missense_Mutation_p.T2381S|SRRM2_uc010bsu.1_Missense_Mutation_p.T2285S	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2381	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCAAACCTCACCAGCCCCAGG	0.632													34	87					0	0	0	0	G	2817671	G	G	2817671	3	3	218	1	0	0	0	0	1	0	0	0	15235	507	18	4	7180	4	SRRM2	16	2817671	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	55049	2817671	87537082	107	40085											
C16orf88	400506	broad.mit.edu	37	chr16	19718478	19718478	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaagccacccataagtctGagaaatttcagtttttggtc	11	14	8	8	0	2	2	1	2	1	1	3	3	2	2	2	1	1	1	2	1	3	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:19718478G>C	uc002dgq.2	-	5	1146	c.1131C>G	c.(1129-1131)CTC>CTG	p.L377L		NM_001012991	NP_001013009	Q1ED39	CP088_HUMAN	hypothetical protein LOC400506	377	Interaction with ZFP106 (By similarity).					nucleolus					0						CCATAAGTCTGAGAAATTTCA	0.532													25	61					0	0	0	0	C	19718478	C	C	19718478	2	2	218	1	0	0	0	0	0	0	0	1	1847	1277	45	2		2	C16orf88	16	19718478	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	16900807	19718478	70636275	108	40086											
XPO6	23214	broad.mit.edu	37	chr16	28167615	28167615	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acagttctggctgctgccgtTaactgacgccatctttctgg	6	13	10	12	2	3	1	0	1	3	0	3	1	3	1	2	2	3	4	2	2	1	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:28167615T>C	uc002dpa.1	-	7	1378	c.877A>G	c.(877-879)AAC>GAC	p.N293D	XPO6_uc002dpb.1_Missense_Mutation_p.N279D|XPO6_uc010vcp.1_Missense_Mutation_p.N293D	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	293					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						CTGCTGCCGTTAACTGACGCC	0.577													29	67					0	0	0	0	C	28167615	C	C	28167615	3	2	218	1	0	0	0	0	1	0	0	0	17516	1754	61	5	2572	5	XPO6	16	28167615	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	8449137	28167615	62187138	109	40087											
APOB48R	55911	broad.mit.edu	37	chr16	28508717	28508717	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtgaagctttggaaggggtGcttgggcaaggctgggactc	7	9	19	6	0	0	1	0	1	0	0	1	3	0	3	0	7	2	4	0	7	3	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:28508717G>C	uc002dqb.1	+	3	2338	c.2328G>C	c.(2326-2328)GTG>GTC	p.V776V	uc010vct.1_Intron|APOB48R_uc010byg.1_Silent_p.V314V	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	776	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						TGGAAGGGGTGCTTGGGCAAG	0.587													11	24					0	0	0	0	C	28508717	C	C	28508717	2	2	218	1	0	0	0	0	0	0	0	1	786	1306	46	4		4	APOB48R	16	28508717	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	341102	28508717	61846036	110	40088											
SIAH1	6477	broad.mit.edu	37	chr16	48395697	48395697	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaattttcagcttgcttgcGtgttcctatcagctgtacga	9	15	8	9	2	2	0	2	0	0	0	3	1	3	0	1	0	5	5	1	0	4	7			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:48395697G>A	uc002efo.1	-	2	760	c.643C>T	c.(643-645)CGC>TGC	p.R215C	uc002efk.1_RNA|SIAH1_uc002efl.2_RNA|SIAH1_uc002efn.1_Missense_Mutation_p.R246C	NM_003031	NP_003022	Q8IUQ4	SIAH1_HUMAN	seven in absentia homolog 1 isoform a	215	SBD.			TR->AA: In mutant D; does not impair its ability to interact with CACYBP and degrade CTNNB1 and PML; when associated with A-124; A-231 and A-232.	axon guidance|cell cycle|neuron apoptosis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	beta-catenin destruction complex|cytosol|nucleus	protein C-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_cancers(37;0.157)|all_lung(18;0.11)|Breast(268;0.238)				GCTTGCTTGCGTGTTCCTATC	0.443													14	66					0	0	0	0	A	48395697	A	A	48395697	3	1	218	1	0	0	0	0	1	0	0	0	14364	1145	40	1	209	1	SIAH1	16	48395697	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	19886980	48395697	41959056	111	40089											
CX3CL1	6376	broad.mit.edu	37	chr16	57416529	57416529	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaggccagagaactctcTggagcgggaggagatgggtc	9	5	16	11	1	1	2	0	0	1	2	3	6	1	4	3	5	2	0	3	5	1	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:57416529T>A	uc002eli.2	+	3	846	c.779T>A	c.(778-780)CTG>CAG	p.L260Q		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	260	Mucin-like stalk.|Extracellular (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						GAGAACTCTCTGGAGCGGGAG	0.667													22	44					0	0	0	0	A	57416529	A	A	57416529	3	1	218	1	0	0	0	0	1	0	0	0	4091	1580	55	5	789	5	CX3CL1	16	57416529	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	9020832	57416529	32938224	112	40090											
COG4	25839	broad.mit.edu	37	chr16	70551611	70551611	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatcattccagccagctgcTttgcatctccctcaatcagc	8	12	6	15	0	4	1	3	1	1	0	6	1	5	1	3	0	5	3	3	0	1	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:70551611T>C	uc002ezc.2	-	3	298	c.287A>G	c.(286-288)AAG>AGG	p.K96R	COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.K96R|COG4_uc002eze.2_5'UTR	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	92	Interacts with STX5.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				AGCCAGCTGCTTTGCATCTCC	0.443													32	62					0	0	0	0	C	70551611	C	C	70551611	3	2	218	1	0	0	0	0	1	0	0	0	3675	1609	56	5	2150	5	COG4	16	70551611	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	13135082	70551611	19803142	113	40091											
HYDIN	54768	broad.mit.edu	37	chr16	71212876	71212876	+	Frame_Shift_Del	DEL	G	-	-																															ggaacttcatagacttcacaGggagtgtagttctgaaatat																										TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:71212876delG	uc002ezr.2	-	4	464	c.336delC	c.(334-336)CCCfs	p.P112fs	HYDIN_uc010cfz.1_5'UTR|HYDIN_uc002ezv.2_Frame_Shift_Del_p.P112fs|HYDIN_uc010vmc.1_Frame_Shift_Del_p.P129fs|HYDIN_uc010vmd.1_Frame_Shift_Del_p.P139fs|HYDIN_uc002ezw.3_Frame_Shift_Del_p.P129fs	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	112										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AGACTTCACAGGGAGTGTAGT	0.388													---	---	---								-	71212876	-	-	71212876	7	5	218	1	0	1	0	1	0	0	0	0	7506	987	35	0	15370	0	HYDIN	16	71212876	Frame_Shift_Del	DEL	G	TCGA-CV-7091-01A-11D-2012-08	661265	71212876	19141877	114	40092											
FBXO31	79791	broad.mit.edu	37	chr16	87365007	87365007	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtacaggctgaaggatttcaGctccagccagacgaacccga	12	6	11	12	2	1	2	1	1	0	1	2	5	2	3	3	2	4	3	3	2	3	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr16:87365007G>C	uc002fjw.2	-	9	1551	c.1507C>G	c.(1507-1509)CTG>GTG	p.L503V	FBXO31_uc010vot.1_Missense_Mutation_p.L331V|FBXO31_uc002fjv.2_Missense_Mutation_p.L395V	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	503					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		AAGGATTTCAGCTCCAGCCAG	0.622													13	24					0	0	0	0	C	87365007	C	C	87365007	3	2	218	1	0	0	0	0	1	0	0	0	5773	962	34	4	116	4	FBXO31	16	87365007	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	16152131	87365007	2989746	115	40093											
ATP1B2	482	broad.mit.edu	37	chr17	7557506	7557506	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acccagctgggcaactgctcCggcattggggactccaccca	8	6	11	16	1	0	0	0	0	0	0	2	1	2	1	4	4	3	4	4	4	1	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr17:7557506C>T	uc002gif.1	+	4	1066	c.483C>T	c.(481-483)TCC>TCT	p.S161S		NM_001678	NP_001669	P14415	AT1B2_HUMAN	Na+/K+ -ATPase beta 2 subunit	161	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		GCAACTGCTCCGGCATTGGGG	0.562													149	122					0	0	0	0	T	7557506	T	T	7557506	2	4	218	1	0	0	0	0	0	0	0	1	1135	639	23	1		1	ATP1B2	17	7557506	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08		7557506	73637704	116	40094											
TP53	7157	broad.mit.edu	37	chr17	7579718	7579718	+	Frame_Shift_Del	DEL	A	-	-																															accagaacgttgttttcaggAagtctgaaagacaagagcag																										TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr17:7579718delA	uc002gim.2	-	3	272	c.78delT	c.(76-78)CTTfs	p.L26fs	TP53_uc002gig.1_Frame_Shift_Del_p.L26fs|TP53_uc002gih.2_Frame_Shift_Del_p.L26fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.L26fs|TP53_uc010cni.1_Frame_Shift_Del_p.L26fs|TP53_uc002gij.2_Frame_Shift_Del_p.L26fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Frame_Shift_Del_p.L26fs|TP53_uc002gio.2_Intron|TP53_uc010vug.1_5'UTR|TP53_uc010cnk.1_Frame_Shift_Del_p.L41fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	26	Transcription activation (acidic).|Interaction with HRMT1L2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L26fs*18(1)|p.P13fs*18(1)|p.L26fs*11(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGTTTTCAGGAAGTCTGAAAG	0.408		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7579718	-	-	7579718	7	5	218	1	0	1	0	1	0	0	0	0	16448	233	9	0	1228	0	TP53	17	7579718	Frame_Shift_Del	DEL	A	TCGA-CV-7091-01A-11D-2012-08	22212	7579718	73615492	117	40095											
TNFRSF13B	23495	broad.mit.edu	37	chr17	16875383	16875383	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcctgctccggcccaggcCactcattactcaggatgctt	6	10	9	16	2	2	0	2	0	0	0	4	1	3	1	4	3	3	2	4	3	1	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr17:16875383C>A	uc002gqs.1	-	1	20	c.7G>T	c.(7-9)GGC>TGC	p.G3C	TNFRSF13B_uc010vwt.1_RNA|TNFRSF13B_uc002gqt.1_Missense_Mutation_p.G3C|TNFRSF13B_uc010vwu.1_Missense_Mutation_p.G3C	NM_012452	NP_036584	O14836	TR13B_HUMAN	tumor necrosis factor receptor 13B	3	Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity			kidney(2)	2						CGGCCCAGGCCACTCATTACT	0.582									IgA_Deficiency_Selective				13	43					9.31168e-06	1.81852e-05	1	0	A	16875383	A	A	16875383	3	1	218	1	0	0	0	0	1	0	0	0	16353	594	21	4	894	4	TNFRSF13B	17	16875383	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	9295665	16875383	64319827	118	40096											
NFE2L1	4779	broad.mit.edu	37	chr17	46128746	46128746	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctcctcagtcaggtgagggCcctggacaggttccaggtgc	6	8	15	12	0	2	1	2	1	0	0	4	2	4	2	3	5	1	2	3	5	0	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr17:46128746C>A	uc002imz.3	+	2	917	c.266C>A	c.(265-267)GCC>GAC	p.A89D	NFE2L1_uc002ina.3_Missense_Mutation_p.A89D|NFE2L1_uc002inb.3_Missense_Mutation_p.A89D|NFE2L1_uc002inc.1_Missense_Mutation_p.A89D	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	89					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						CAGGTGAGGGCCCTGGACAGG	0.582													25	94					3.08376e-08	6.16752e-08	1	0	A	46128746	A	A	46128746	3	1	218	1	0	0	0	0	1	0	0	0	10421	739	26	4	268	4	NFE2L1	17	46128746	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	29253363	46128746	35066464	119	40097											
BAHCC1	57597	broad.mit.edu	37	chr17	79410355	79410355	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctgggtggcctcaaggcCagctgcatccagcaggaagc	8	5	15	13	0	1	0	1	0	0	0	2	1	2	1	4	5	4	3	4	5	2	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr17:79410355C>T	uc002kaf.2	+	3	1980	c.1980C>T	c.(1978-1980)GCC>GCT	p.A660A	BAHCC1_uc002kae.2_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	660							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GCCTCAAGGCCAGCTGCATCC	0.642													6	14					0	0	0	0	T	79410355	T	T	79410355	2	4	218	1	0	0	0	0	0	0	0	1	1298	581	21	4		4	BAHCC1	17	79410355	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08	33281609	79410355	1784855	120	40098											
CDH7	1005	broad.mit.edu	37	chr18	63547834	63547834	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agacccggagggatgtgactCcagaaattcaattcctgagt	12	9	11	9	1	1	4	1	2	0	2	3	6	3	6	3	2	0	0	3	2	2	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr18:63547834C>T	uc002ljz.2	+	12	2387	c.2062C>T	c.(2062-2064)CCA>TCA	p.P688S	CDH7_uc002lkb.2_Missense_Mutation_p.P688S	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	688	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GGATGTGACTCCAGAAATTCA	0.478													13	42					0	0	0	0	T	63547834	T	T	63547834	3	4	218	1	0	0	0	0	1	0	0	0	3130	855	30	2	2104	2	CDH7	18	63547834	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08		63547834	14529414	121	40099											
DSEL	92126	broad.mit.edu	37	chr18	65180979	65180979	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctgggccagaaaaacataCtgtgtgacggatttagctgt	11	10	12	8	2	0	2	0	1	0	1	0	3	0	3	1	2	3	2	1	2	4	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr18:65180979C>G	uc002lke.1	-	2	2121	c.897G>C	c.(895-897)CAG>CAC	p.Q299H		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	289						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				GAAAAACATACTGTGTGACGG	0.388													14	69					0	0	0	0	G	65180979	G	G	65180979	3	3	218	1	0	0	0	0	1	0	0	0	4797	564	20	4	2775	4	DSEL	18	65180979	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	1633145	65180979	12896269	122	40100											
FBN3	84467	broad.mit.edu	37	chr19	8131097	8131097	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggcccaggtgtgagaggttCaggcccaaggtcagcagggc	8	5	17	11	1	2	1	2	1	0	1	2	2	2	1	2	6	1	2	2	6	1	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:8131097C>T	uc002mjf.2	-	63	8157	c.8136G>A	c.(8134-8136)CTG>CTA	p.L2712L	FBN3_uc002mje.2_Silent_p.L508L	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2712						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GTGAGAGGTTCAGGCCCAAGG	0.662													8	15					0	0	0	0	T	8131097	T	T	8131097	2	4	218	1	0	0	0	0	0	0	0	1	5736	813	29	2		2	FBN3	19	8131097	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08		8131097	50997886	123	40101											
FBN3	84467	broad.mit.edu	37	chr19	8188397	8188397	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgaagccccccgcacaggcGcagtggaagctgcccaccgt	8	3	13	17	4	0	0	0	0	0	0	0	2	0	1	5	2	3	3	5	2	2	0	rs145240162	byFrequency	TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:8188397G>A	uc002mjf.2	-	23	3054	c.3033C>T	c.(3031-3033)TGC>TGT	p.C1011C		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1011	EGF-like 12; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCGCACAGGCGCAGTGGAAGC	0.597													16	26					0	0	0	0	A	8188397	A	A	8188397	2	1	218	1	0	0	0	0	0	0	0	1	5736	1079	38	1		1	FBN3	19	8188397	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	57300	8188397	50940586	124	40102											
OR2Z1	284383	broad.mit.edu	37	chr19	8842012	8842012	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctcaggggtgctgatcctaAtgctccctctttccctcatc	5	13	7	16	0	3	1	2	1	1	0	7	1	6	1	4	2	2	2	4	2	1	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:8842012A>C	uc010xkg.1	+	1	622	c.622A>C	c.(622-624)ATG>CTG	p.M208L		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						GCTGATCCTAATGCTCCCTCT	0.582													34	51					0	0	0	0	C	8842012	C	C	8842012	3	2	218	1	0	0	0	0	1	0	0	0	11090	101	4	5	624	5	OR2Z1	19	8842012	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	653615	8842012	50286971	125	40103											
MUC16	94025	broad.mit.edu	37	chr19	9049680	9049680	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtgaccagtggggtcagtgCatctagttcactaggtgaga	10	10	14	7	0	3	2	2	2	1	1	3	3	3	2	1	3	1	2	1	3	2	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:9049680C>G	uc002mkp.2	-	5	32155	c.31951G>C	c.(31951-31953)GCA>CCA	p.A10651P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10653	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGGTCAGTGCATCTAGTTCA	0.473													14	63					0	0	0	0	G	9049680	G	G	9049680	3	3	218	1	0	0	0	0	1	0	0	0	10026	710	25	4	11892	4	MUC16	19	9049680	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	207668	9049680	50079303	126	40104											
SLC44A2	57153	broad.mit.edu	37	chr19	10753954	10753954	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgggacctctctccacaGtggaggacctggagaggaat	9	8	13	11	0	2	1	0	0	2	1	4	6	3	5	3	5	0	0	3	5	1	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:10753954G>A	uc002mpf.2	+	22	2154	c.2015_splice	c.e22-1	p.L672_splice	SLC44A2_uc002mpe.3_Splice_Site_p.L670_splice|SLC44A2_uc002mpg.1_3'UTR|SLC44A2_uc002mph.2_Splice_Site_p.L221_splice|SLC44A2_uc002mpi.2_Splice_Site	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1						positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	TCTCTCCACAGTGGAGGACCT	0.592													7	6					0	0	0	0	A	10753954	A	A	10753954	5	1	218	1	0	0	0	0	0	0	1	0	14700	1043	36	4	2135	4	SLC44A2	19	10753954	Splice_Site	SNP	G	TCGA-CV-7091-01A-11D-2012-08	1704274	10753954	48375029	127	40105											
ZNF844	284391	broad.mit.edu	37	chr19	12186456	12186456	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actctatgattgtaaagaatGtggaaaaaccttcatatccc	15	12	6	8	0	2	2	1	1	1	1	3	3	3	3	2	1	1	1	2	1	7	5			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:12186456G>A	uc002mtb.2	+	4	664	c.521G>A	c.(520-522)TGT>TAT	p.C174Y	ZNF844_uc010dym.1_Missense_Mutation_p.C17Y	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	174	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTAAAGAATGTGGAAAAACC	0.383													12	20					0	0	0	0	A	12186456	A	A	12186456	3	1	218	1	0	0	0	0	1	0	0	0	18257	1377	48	4	535	4	ZNF844	19	12186456	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	1432502	12186456	46942527	128	40106											
ZNF564	163050	broad.mit.edu	37	chr19	12639154	12639154	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatttttgtaccaatcttcaAtgctctggtcttcccatttt	7	19	5	10	0	4	0	1	0	3	0	5	1	5	0	2	1	2	2	2	1	3	7			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:12639154A>C	uc002mty.2	-	3	365	c.155T>G	c.(154-156)ATT>AGT	p.I52S	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCAATCTTCAATGCTCTGGTC	0.299													5	32					0	0	0	0	C	12639154	C	C	12639154	3	2	218	1	0	0	0	0	1	0	0	0	18062	101	4	5	1514	5	ZNF564	19	12639154	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	452698	12639154	46489829	129	40107											
CD97	976	broad.mit.edu	37	chr19	14513676	14513676	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagaccctcctgccaaggTctctgctcactctgctcact	8	10	7	16	0	4	1	2	0	2	1	6	2	5	1	3	1	3	2	3	1	2	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:14513676T>C	uc002myl.2	+	12	1572	c.1449_splice	c.e12+2	p.K483_splice	CD97_uc002mym.2_Splice_Site_p.K434_splice|CD97_uc002myn.2_Splice_Site_p.K390_splice	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor						cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						CCTGCCAAGGTCTCTGCTCAC	0.368													18	45					0	0	0	0	C	14513676	C	C	14513676	5	2	218	1	0	0	0	0	0	0	1	0	3064	1681	58	5	1497	5	CD97	19	14513676	Splice_Site	SNP	T	TCGA-CV-7091-01A-11D-2012-08	1874522	14513676	44615307	130	40108											
CYP4F2	8529	broad.mit.edu	37	chr19	15989681	15989681	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtcaggcaggacgcggaagCgcagcagcgtgagcgccagg	9	2	19	11	5	1	1	1	1	0	0	1	3	1	3	1	5	4	3	1	5	1	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:15989681C>T	uc002nbs.1	-	13	1513	c.1463G>A	c.(1462-1464)CGC>CAC	p.R488H	CYP4F2_uc010xot.1_Missense_Mutation_p.R339H	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	488					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						GACGCGGAAGCGCAGCAGCGT	0.677													9	68					0	0	0	0	T	15989681	T	T	15989681	3	4	218	1	0	0	0	0	1	0	0	0	4205	768	27	1	103	1	CYP4F2	19	15989681	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	1476005	15989681	43139302	131	40109											
KCNN1	3780	broad.mit.edu	37	chr19	18084991	18084991	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcctgggccaccggcgggcGctcttcgagaagcggaagcg	6	4	17	14	7	1	1	0	0	1	1	2	3	1	2	3	4	2	1	3	4	2	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:18084991G>C	uc002nht.2	+	3	604	c.294G>C	c.(292-294)GCG>GCC	p.A98A	KCNN1_uc010xqa.1_Silent_p.A98A	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	98					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						ACCGGCGGGCGCTCTTCGAGA	0.627													4	17					0	0	0	0	C	18084991	C	C	18084991	2	2	218	1	0	0	0	0	0	0	0	1	8117	1074	38	3		3	KCNN1	19	18084991	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	2095310	18084991	41043992	132	40110											
IL12RB1	3594	broad.mit.edu	37	chr19	18191667	18191667	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtagagctgcagggtcacCtcaggagacttctctgtctg	7	12	12	10	0	4	2	2	0	2	2	5	3	4	2	1	2	2	3	1	2	1	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:18191667C>T	uc002nhw.1	-	4	448	c.384G>A	c.(382-384)GAG>GAA	p.E128E	IL12RB1_uc010xqb.1_Silent_p.E128E|IL12RB1_uc002nhx.1_Silent_p.E168E|IL12RB1_uc002nhy.2_Silent_p.E128E	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	128	Extracellular (Potential).|Fibronectin type-III 1.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						GCAGGGTCACCTCAGGAGACT	0.582													14	76					0	0	0	0	T	18191667	T	T	18191667	2	4	218	1	0	0	0	0	0	0	0	1	7665	680	24	4		4	IL12RB1	19	18191667	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08	106676	18191667	40937316	133	40111											
ZNF45	7596	broad.mit.edu	37	chr19	44418581	44418582	+	Missense_Mutation	DNP	GC	AT	AT																															aactaaagctcttgccacatGcattgcatttgtatggtttc																										TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:44418581_44418582GC>AT	uc002oxu.1	-	4	1105_1106	c.1006_1007GC>AT	c.(1006-1008)GCA>ATA	p.A336I	ZNF45_uc002oxw.1_Missense_Mutation_p.A336I|ZNF45_uc002oxv.1_Missense_Mutation_p.A336I	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	336	C2H2-type 7.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CTTGCCACATGCATTGCATTTG	0.455													22	48					0	0	0	0	AT	44418582	AT	AT	44418581	3	1	218	1	0	0	0	0	1	0	0	0	17988	1319	46	4	1045	4	ZNF45	19	44418581	Missense_Mutation	DNP	GC	TCGA-CV-7091-01A-11D-2012-08	26226914	44418581	14710402	134	40112											
CEACAM20	125931	broad.mit.edu	37	chr19	45016078	45016078	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgcagcatcactcaccagTtcgactctgatccgtccctg	7	11	7	16	2	4	1	2	1	2	0	7	2	6	1	3	0	2	3	3	0	0	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:45016078T>A	uc010ejn.1	-	10	1588	c.1572A>T	c.(1570-1572)GAA>GAT	p.E524D	CEACAM20_uc010ejo.1_Missense_Mutation_p.E524D|CEACAM20_uc010ejp.1_Missense_Mutation_p.E431D|CEACAM20_uc010ejq.1_Missense_Mutation_p.E431D	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	524	Cytoplasmic (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				CACTCACCAGTTCGACTCTGA	0.488													3	10					0	0	0	0	A	45016078	A	A	45016078	3	1	218	1	0	0	0	0	1	0	0	0	3206	1722	60	5	234	5	CEACAM20	19	45016078	Missense_Mutation	SNP	T	TCGA-CV-7091-01A-11D-2012-08	597497	45016078	14112905	135	40113											
HAS1	3036	broad.mit.edu	37	chr19	52222698	52222698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacgtacgtggcggggtcctCgtcagcgaagacctcgcgga	7	6	15	13	7	1	1	1	0	0	1	4	3	2	2	2	4	2	1	2	4	2	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	68d635f1-65fb-4395-99c0-a34514289521	g.chr19:52222698C>T	uc002pxo.1	-	2	498	c.463G>A	c.(463-465)GAG>AAG	p.E155K	HAS1_uc010epc.1_5'Flank|HAS1_uc010epd.1_Missense_Mutation_p.E120K|HAS1_uc002pxn.1_Missense_Mutation_p.E162K|HAS1_uc002pxp.1_Missense_Mutation_p.E154K	NM_001523	NP_001514	Q92839	HAS1_HUMAN	hyaluronan synthase 1	155	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			ovary(1)|pancreas(1)	2		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GCGGGGTCCTCGTCAGCGAAG	0.572													3	3					0	0	0	0	T	52222698	T	T	52222698	3	4	218	1	0	0	0	0	1	0	0	0	7000	893	31	1	1289	1	HAS1	19	52222698	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	7206620	52222698	6906285	136	40114											
ZNF616	90317	broad.mit.edu	37	chr19	52618924	52618924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgactgaagaccttgccaCattcattgcatttgtaaggt	10	14	9	8	0	1	3	1	2	0	1	1	3	1	3	2	1	2	3	2	1	2	6			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:52618924C>T	uc002pym.2	-	4	1776	c.1493G>A	c.(1492-1494)TGT>TAT	p.C498Y	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	498	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		GACCTTGCCACATTCATTGCA	0.403													13	97					0	0	0	0	T	52618924	T	T	52618924	3	4	218	1	0	0	0	0	1	0	0	0	18108	478	17	4	856	4	ZNF616	19	52618924	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	396226	52618924	6510059	137	40115											
NLRP7	199713	broad.mit.edu	37	chr19	55441964	55441964	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actcaagtccaggtttgtgaGgctgcaggcttcttggagcg	7	11	14	9	1	2	1	1	1	1	0	3	2	3	2	1	4	2	4	1	4	1	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:55441964G>T	uc002qih.3	-	9	2789	c.2713C>A	c.(2713-2715)CTC>ATC	p.L905I	NLRP7_uc002qig.3_Missense_Mutation_p.L877I|NLRP7_uc002qii.3_Missense_Mutation_p.L905I|NLRP7_uc010esk.2_Missense_Mutation_p.L905I|NLRP7_uc010esl.2_Missense_Mutation_p.L933I	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	905	LRR 8.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AGGTTTGTGAGGCTGCAGGCT	0.463													50	66					3.31993e-32	7.25142e-32	1	0	T	55441964	T	T	55441964	3	4	218	1	0	0	0	0	1	0	0	0	10536	1000	35	4	412	4	NLRP7	19	55441964	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	2823040	55441964	3687019	138	40116											
ZNF470	388566	broad.mit.edu	37	chr19	57089845	57089845	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctatgagtgtaaagaatgtgGaaaagccttcaggcagagtg	14	9	13	5	0	1	3	1	1	0	2	1	4	1	4	1	2	1	2	1	2	6	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:57089845G>A	uc002qnl.3	+	6	2724	c.2048G>A	c.(2047-2049)GGA>GAA	p.G683E	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	683	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AAAGAATGTGGAAAAGCCTTC	0.343													11	47					0	0	0	0	A	57089845	A	A	57089845	3	1	218	1	0	0	0	0	1	0	0	0	17996	1174	41	2	2062	2	ZNF470	19	57089845	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	1647881	57089845	2039138	139	40117											
ZNF547	284306	broad.mit.edu	37	chr19	57879930	57879930	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggtcccctggcgatggcaGaaatgaaccctgcacaggtg	10	6	14	11	1	0	2	0	1	0	1	1	3	1	2	3	4	2	2	3	4	2	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:57879930G>A	uc002qol.2	+	2	200	c.7G>A	c.(7-9)GAA>AAA	p.E3K	ZNF547_uc010ygx.1_Missense_Mutation_p.E3K	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGCGATGGCAGAAATGAACCC	0.493													7	56					0	0	0	0	A	57879930	A	A	57879930	3	1	218	1	0	0	0	0	1	0	0	0	18046	943	33	2	9	2	ZNF547	19	57879930	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	790085	57879930	1249053	140	40118											
A1BG	1	broad.mit.edu	37	chr19	58862944	58862944	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttctccccgcgccgtagctgGaagtccactccactcagggg	6	8	11	16	3	2	0	1	0	1	0	5	1	4	1	5	3	1	2	5	3	2	2	rs117988784	by1000genomes	TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:58862944G>T	uc002qsd.3	-	5	785	c.723C>A	c.(721-723)TTC>TTA	p.F241L	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	241	Ig-like V-type 3.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		GCCGTAGCTGGAAGTCCACTC	0.637													15	23					1.62849e-17	3.51077e-17	1	0	T	58862944	T	T	58862944	3	4	218	1	0	0	0	0	1	0	0	0	1	1165	41	2	780	2	A1BG	19	58862944	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	983014	58862944	266039	141	40119											
SLC27A5	10998	broad.mit.edu	37	chr19	59011917	59011917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgcccagggccccgcagcGccccacatagttgactaagc	8	6	10	17	2	0	1	0	1	0	0	0	1	0	1	5	1	3	2	5	1	2	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr19:59011917G>A	uc002qtc.2	-	5	1449	c.1339C>T	c.(1339-1341)CGC>TGC	p.R447C	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	447	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		GCCCCGCAGCGCCCCACATAG	0.602													10	32					0	0	0	0	A	59011917	A	A	59011917	3	1	218	1	0	0	0	0	1	0	0	0	14593	1087	38	1	757	1	SLC27A5	19	59011917	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	148973	59011917	117066	142	40120											
C20orf54	113278	broad.mit.edu	37	chr20	745904	745904	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcttggtacgctgtctgatAtctcagtgacattgacgcag	8	12	12	9	2	2	3	1	3	2	0	3	3	2	3	0	2	1	4	0	2	2	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr20:745904A>G	uc002wed.3	-	2	854	c.515T>C	c.(514-516)ATA>ACA	p.I172T	C20orf54_uc002wee.2_Missense_Mutation_p.I172T	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	172					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						GCTGTCTGATATCTCAGTGAC	0.577													15	73					0	0	0	0	G	745904	G	G	745904	3	3	218	1	0	0	0	0	1	0	0	0	2124	449	16	5	910	5	C20orf54	20	745904	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08		745904	62279616	143	40121											
ITPA	3704	broad.mit.edu	37	chr20	3202541	3202541	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggctgggacccctgctttCagcctgatggatatgagcag	7	11	13	10	0	1	2	1	2	0	0	1	4	1	4	3	3	3	3	3	3	1	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr20:3202541C>T	uc002wid.2	+	7	608	c.466C>T	c.(466-468)CAG>TAG	p.Q156*	ITPA_uc002wie.2_Nonsense_Mutation_p.Q139*|ITPA_uc002wif.2_RNA	NM_033453	NP_258412	Q9BY32	ITPA_HUMAN	inosine triphosphatase isoform a	156					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			ovary(1)	1						CCCCTGCTTTCAGCCTGATGG	0.617													9	41					0	0	0	0	T	3202541	T	T	3202541	4	4	218	1	0	0	0	0	0	1	0	0	7954	827	29	2	492	2	ITPA	20	3202541	Nonsense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	2456637	3202541	59822979	144	40122											
PROCR	10544	broad.mit.edu	37	chr20	33764086	33764086	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgtgagtttccggccggaGagagccttgtggcaggcaga	7	10	16	8	2	0	3	0	1	0	2	1	5	1	4	3	4	1	3	3	4	0	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr20:33764086G>A	uc002xbt.2	+	3	622	c.438G>A	c.(436-438)GAG>GAA	p.E146E	EDEM2_uc010zuv.1_Intron|PROCR_uc010zuw.1_Silent_p.E183E	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	endothelial protein C receptor precursor	146	Extracellular (Potential).				antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity				0			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	TCCGGCCGGAGAGAGCCTTGT	0.607													40	76					0	0	0	0	A	33764086	A	A	33764086	2	1	218	1	0	0	0	0	0	0	0	1	12609	933	33	2		2	PROCR	20	33764086	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	30561545	33764086	29261434	145	40123											
CD40	958	broad.mit.edu	37	chr20	44756788	44756788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttctccaggtccccaggatCggctgagagccctggtggtg	5	10	14	12	1	1	1	0	1	1	1	4	3	2	2	4	5	1	1	4	5	0	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr20:44756788C>T	uc002xrg.1	+	7	648	c.571C>T	c.(571-573)CGG>TGG	p.R191W	CD40_uc002xrh.1_Missense_Mutation_p.S170L|CD40_uc002xri.1_Missense_Mutation_p.S204L|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA|CD40_uc002xrl.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	191	Extracellular (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	TCCCCAGGATCGGCTGAGAGC	0.547									Immune_Deficiency_with_Hyper-IgM		OREG0025991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	102					0	0	0	0	T	44756788	T	T	44756788	3	4	218	1	0	0	0	0	1	0	0	0	3030	893	31	1	597	1	CD40	20	44756788	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	10992702	44756788	18268732	146	40124											
SULF2	55959	broad.mit.edu	37	chr20	46301111	46301111	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatgcagcttcagcttcccCgtggcgtcctccacacactg	6	11	8	16	2	1	0	1	0	0	0	4	0	4	0	4	1	3	3	4	1	1	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr20:46301111C>A	uc002xto.2	-	11	1737	c.1407G>T	c.(1405-1407)ACG>ACT	p.T469T	SULF2_uc002xtr.2_Silent_p.T469T|SULF2_uc002xtq.2_Silent_p.T469T	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	469					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TCAGCTTCCCCGTGGCGTCCT	0.652													4	31					0.00024832	0.000476545	1	0	A	46301111	A	A	46301111	2	1	218	1	0	0	0	0	0	0	0	1	15437	639	23	3		3	SULF2	20	46301111	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08	1544323	46301111	16724409	147	40125											
COMT	1312	broad.mit.edu	37	chr22	19950331	19950331	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggccatgaacgtgggcgaCaagaaaggtggggtccgggc	9	5	19	8	3	0	2	0	1	0	1	1	3	1	2	2	6	1	0	2	6	3	0			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr22:19950331C>T	uc002zqu.2	+	3	531	c.282C>T	c.(280-282)GAC>GAT	p.D94D	COMT_uc002zqt.2_Silent_p.D94D|COMT_uc002zqv.2_Silent_p.D94D|COMT_uc002zqw.2_Silent_p.D94D|COMT_uc011ahd.1_Silent_p.D94D|COMT_uc002zqx.2_Silent_p.D94D	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	94					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	ACGTGGGCGACAAGAAAGGTG	0.612													7	35					0	0	0	0	T	19950331	T	T	19950331	2	4	218	1	0	0	0	0	0	0	0	1	3740	477	17	4		4	COMT	22	19950331	Silent	SNP	C	TCGA-CV-7091-01A-11D-2012-08		19950331	31354235	148	40126											
HIC2	23119	broad.mit.edu	37	chr22	21800083	21800083	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcttattctgagctgggggGcacccctgatgagcccatgg	6	10	13	12	0	2	3	0	3	2	0	2	3	2	3	3	4	2	2	3	4	1	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr22:21800083G>T	uc002zur.3	+	3	1129	c.899G>T	c.(898-900)GGC>GTC	p.G300V	HIC2_uc002zus.3_Missense_Mutation_p.G300V	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	300					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GAGCTGGGGGGCACCCCTGAT	0.677													15	41					8.60227e-14	1.77389e-13	1	0	T	21800083	T	T	21800083	3	4	218	1	0	0	0	0	1	0	0	0	7141	1203	42	4	905	4	HIC2	22	21800083	Missense_Mutation	SNP	G	TCGA-CV-7091-01A-11D-2012-08	1849752	21800083	29504483	149	40127											
RGL4	266747	broad.mit.edu	37	chr22	24034239	24034239	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaggaagctgctcacaaatCtgcctgcagctgcagtcttg	9	10	11	11	0	3	1	1	1	2	0	3	2	3	2	1	1	6	5	1	1	2	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chr22:24034239C>G	uc002zxn.2	+	1	1192	c.22C>G	c.(22-24)CTG>GTG	p.L8V	LOC91316_uc002zxh.3_RNA|LOC91316_uc002zxi.3_RNA|LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Missense_Mutation_p.L8V|RGL4_uc002zxp.1_Translation_Start_Site|RGL4_uc002zxq.2_Translation_Start_Site	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	8					small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						GCTCACAAATCTGCCTGCAGC	0.612													23	31					0	0	0	0	G	24034239	G	G	24034239	3	3	218	1	0	0	0	0	1	0	0	0	13344	912	32	2	24	2	RGL4	22	24034239	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	2234156	24034239	27270327	150	40128											
APOL5	80831	broad.mit.edu	37	chr22	36113815	36113816	+	5'Flank	INS	-	GA	GA																															aaaaagaaagaaaagaaaagINSaaaaaaaaataggtgaggac																								rs72568096		TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	68d635f1-65fb-4395-99c0-a34514289521	g.chr22:36113815_36113816insGA	uc003aof.2	+							NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5						lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						gaaaagaaaaGAAAAAAAAATA	0.153													---	---	---								GA	36113816	GA	GA	36113815	6	5	218	0	1	1	1	0	0	0	0	0	809	957	33	0		0	APOL5	22	36113815	5'Flank	INS	-	TCGA-CV-7091-01A-11D-2012-08	12079576	36113815	15190751	151	40129											
SLC25A6	293	broad.mit.edu	37	chrX	1508618	1508618	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atctgcttgctggcgtgctgGacctgggggacgcagagggt	5	9	18	9	2	1	1	0	0	1	1	1	3	1	3	1	5	3	4	1	5	0	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:1508618G>C	uc004cpt.2	-	2	210	c.114C>G	c.(112-114)GTC>GTG	p.V38V	SLC25A6_uc004cpu.2_RNA	NM_001636	NP_001627	P12236	ADT3_HUMAN	adenine nucleotide translocator 3	38	Solcar 1.|Helical; Name=1; (By similarity).				active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	TGGCGTGCTGGACCTGGGGGA	0.552													26	199					0	0	0	0	C	1508618	C	C	1508618	2	2	218	1	0	0	0	0	0	0	0	1	14577	1161	41	2		2	SLC25A6	23	1508618	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08		1508618	153761942	152	40130											
FRMPD4	9758	broad.mit.edu	37	chrX	12735807	12735807	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagagcagaccgagttcccGgcctccaagacccccgctgg	9	4	12	16	3	0	3	0	0	0	3	2	5	2	3	6	2	1	3	6	2	2	1			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:12735807G>A	uc004cuz.1	+	16	3368	c.2862G>A	c.(2860-2862)CCG>CCA	p.P954P	FRMPD4_uc011mij.1_Silent_p.P946P	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	954					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CCGAGTTCCCGGCCTCCAAGA	0.612													76	42					0	0	0	0	A	12735807	A	A	12735807	2	1	218	1	0	0	0	0	0	0	0	1	6093	1103	39	1		1	FRMPD4	23	12735807	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	11227189	12735807	142534753	153	40131											
ACOT9	23597	broad.mit.edu	37	chrX	23724804	23724804	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtcctctcctcagcgctgggGgccattttcagtaacgacgt	6	11	11	13	3	3	0	2	0	1	0	5	1	4	0	3	2	2	2	3	2	1	3			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:23724804G>A	uc004dap.2	-	10	902	c.756C>T	c.(754-756)GCC>GCT	p.A252A	ACOT9_uc004dan.2_Silent_p.A2A|ACOT9_uc004dao.2_Silent_p.A261A|ACOT9_uc004daq.2_Silent_p.A210A|ACOT9_uc004dar.2_Silent_p.A192A|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Silent_p.A192A	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	252					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						CAGCGCTGGGGGCCATTTTCA	0.488													16	44					0	0	0	0	A	23724804	A	A	23724804	2	1	218	1	0	0	0	0	0	0	0	1	157	1219	43	4		4	ACOT9	23	23724804	Silent	SNP	G	TCGA-CV-7091-01A-11D-2012-08	10988997	23724804	131545756	154	40132											
SAT1	6303	broad.mit.edu	37	chrX	23801827	23801827	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agtaatcttaactgaaaaagGtaattcaacagtggcgggac	16	9	10	6	1	2	1	1	1	1	0	2	2	2	2	0	3	2	2	0	3	6	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:23801827G>A	uc004dau.2	+	2	312	c.118_splice	c.e2+1	p.D40_splice	SAT1_uc010nfv.2_Splice_Site_p.D40_splice|SAT1_uc004dav.2_Splice_Site	NM_002970	NP_002961	P21673	SAT1_HUMAN	diamine N-acetyltransferase 1						angiogenesis|polyamine biosynthetic process	cytosol	diamine N-acetyltransferase activity|protein binding				0					Spermine(DB00127)	ACTGAAAAAGGTAATTCAACA	0.488													10	11					0	0	0	0	A	23801827	A	A	23801827	5	1	218	1	0	0	0	0	0	0	1	0	13916	1275	44	4	125	4	SAT1	23	23801827	Splice_Site	SNP	G	TCGA-CV-7091-01A-11D-2012-08	77023	23801827	131468733	155	40133											
MAGEB2	4113	broad.mit.edu	37	chrX	30237076	30237076	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttcctgttgtacaagtatAaaataaaaaagtccgttaca	17	12	6	6	1	0	0	0	0	0	0	2	0	2	0	2	0	2	5	2	0	9	7			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	68d635f1-65fb-4395-99c0-a34514289521	g.chrX:30237076A>G	uc004dbz.2	+	2	482	c.379A>G	c.(379-381)AAA>GAA	p.K127E		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	127	MAGE.						protein binding			ovary(1)	1						GTACAAGTATAAAATAAAAAA	0.473													5	2					0	0	0	0	G	30237076	G	G	30237076	3	3	218	1	0	0	0	0	1	0	0	0	9229	363	13	5	381	5	MAGEB2	23	30237076	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	6435249	30237076	125033484	156	40134											
TRO	7216	broad.mit.edu	37	chrX	54955857	54955857	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaccagtgtctgttttggTggctctcccagctccagtgg	5	12	12	12	0	2	0	0	0	2	0	4	0	3	0	3	3	2	4	3	3	0	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:54955857T>G	uc004dtq.2	+	12	2807	c.2700T>G	c.(2698-2700)GGT>GGG	p.G900G	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Silent_p.G431G|TRO_uc004dtw.2_Silent_p.G503G|TRO_uc004dtx.2_Silent_p.G283G	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	900	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						TCTGTTTTGGTGGCTCTCCCA	0.557													3	51					0	0	0	0	G	54955857	G	G	54955857	2	3	218	1	0	0	0	0	0	0	0	1	16641	1683	59	5		5	TRO	23	54955857	Silent	SNP	T	TCGA-CV-7091-01A-11D-2012-08	24718781	54955857	100314703	157	40135											
NAP1L3	4675	broad.mit.edu	37	chrX	92927031	92927031	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctggatttcaatttctcCagtagcagttgtgcgactct	7	15	10	9	1	3	0	1	0	2	0	4	2	3	1	1	2	2	4	1	2	2	4			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:92927031C>T	uc004efq.2	-	1	1578	c.1273G>A	c.(1273-1275)GGA>AGA	p.G425R	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	425					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						TCAATTTCTCCAGTAGCAGTT	0.443													6	4					0	0	0	0	T	92927031	T	T	92927031	3	4	218	1	0	0	0	0	1	0	0	0	10211	603	21	4	251	4	NAP1L3	23	92927031	Missense_Mutation	SNP	C	TCGA-CV-7091-01A-11D-2012-08	37971174	92927031	62343529	158	40136											
LUZP4	51213	broad.mit.edu	37	chrX	114540929	114540929	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcccgaaaccacttagagAgatctctttctcagtcagac	12	10	7	12	1	3	3	2	0	2	3	6	6	4	3	2	0	1	0	2	0	2	2			TCGA-CV-7091-01A-11D-2012-08	TCGA-CV-7091-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	563c5a89-6dad-467e-b2ea-e07677574a08	54461e7d-d574-467e-8ed5-fc6ba01cc173	g.chrX:114540929A>G	uc004eqa.2	+	4	536	c.502A>G	c.(502-504)AGA>GGA	p.R168G	LUZP4_uc004eqb.2_Missense_Mutation_p.R86G	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	168						nucleus				ovary(2)	2						CCACTTAGAGAGATCTCTTTC	0.448													41	18					0	0	0	0	G	114540929	G	G	114540929	3	3	218	1	0	0	0	0	1	0	0	0	9138	296	11	5	516	5	LUZP4	23	114540929	Missense_Mutation	SNP	A	TCGA-CV-7091-01A-11D-2012-08	21613898	114540929	40729631	159	40137											
SKI	6497	broad.mit.edu	37	chr1	2160913	2160913	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggctgctggtgcccgagctCtacagcagcccgagcgccgc	5	5	15	16	4	1	0	0	0	1	0	1	2	1	0	3	2	7	4	3	2	1	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:2160913C>T	uc001aja.3	+	1	780	c.708C>T	c.(706-708)CTC>CTT	p.L236L		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	236					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		TGCCCGAGCTCTACAGCAGCC	0.682													10	17					0	0	0	0	T	2160913	T	T	2160913	2	4	219	1	0	0	0	0	0	0	0	1	14422	900	32	2		2	SKI	1	2160913	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08		2160913	247089708	1	40138											
KIF1B	23095	broad.mit.edu	37	chr1	10384836	10384836	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagaggctggatttgatgcGagagatgtatgatagggcag	11	9	17	4	1	0	4	0	2	0	2	0	7	0	5	0	3	1	4	0	3	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:10384836G>A	uc001aqx.3	+	26	2760	c.2558G>A	c.(2557-2559)CGA>CAA	p.R853Q	KIF1B_uc001aqw.3_Missense_Mutation_p.R807Q|KIF1B_uc001aqy.2_Missense_Mutation_p.R827Q|KIF1B_uc001aqz.2_Missense_Mutation_p.R853Q|KIF1B_uc001ara.2_Missense_Mutation_p.R813Q|KIF1B_uc001arb.2_Missense_Mutation_p.R839Q	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	853	Potential.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding	p.C853F(1)		ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GATTTGATGCGAGAGATGTAT	0.463													20	53					0	0	0	0	A	10384836	A	A	10384836	3	1	219	1	0	0	0	0	1	0	0	0	8323	1058	37	1	3999	1	KIF1B	1	10384836	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	8223923	10384836	238865785	2	40139											
FAM46B	115572	broad.mit.edu	37	chr1	27332876	27332876	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggaggtggcagtacttgagGaggccaccacctcggatctc	9	7	14	11	1	1	1	0	1	1	0	3	4	1	4	3	6	1	2	3	6	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:27332876G>A	uc010ofj.1	-	2	1009	c.837C>T	c.(835-837)CTC>CTT	p.L279L		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	279										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		AGTACTTGAGGAGGCCACCAC	0.677													9	18					0	0	0	0	A	27332876	A	A	27332876	2	1	219	1	0	0	0	0	0	0	0	1	5598	1161	41	2		2	FAM46B	1	27332876	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	16948040	27332876	221917745	3	40140											
NCDN	23154	broad.mit.edu	37	chr1	36031042	36031042	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgccctggctggccccCgctgccctgcgctcccgctg	0	8	12	21	3	0	0	0	0	0	0	1	0	1	0	5	2	4	5	5	2	0	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:36031042C>T	uc001bza.2	+	8	2095	c.1968C>T	c.(1966-1968)CCC>CCT	p.P656P	NCDN_uc001bzb.2_Silent_p.P656P|NCDN_uc001bzc.2_Silent_p.P639P	NM_001014839	NP_001014839	Q9UBB6	NCDN_HUMAN	neurochondrin isoform 1	656					neuron projection development	cytosol|dendrite|neuronal cell body				large_intestine(2)|pancreas(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GGCTGGCCCCCGCTGCCCTGC	0.682													11	20					0	0	0	0	T	36031042	T	T	36031042	2	4	219	1	0	0	0	0	0	0	0	1	10268	639	23	1		1	NCDN	1	36031042	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	8698166	36031042	213219579	4	40141											
ELAVL4	1996	broad.mit.edu	37	chr1	50610702	50610702	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caatggaccctccagcaacaAcagaaactgtccttctccca	13	7	5	16	0	1	1	0	0	1	1	4	2	3	2	4	1	4	1	4	1	4	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:50610702A>G	uc001csb.2	+	2	351	c.83A>G	c.(82-84)AAC>AGC	p.N28S	ELAVL4_uc001cry.3_Missense_Mutation_p.N31S|ELAVL4_uc001crz.3_Missense_Mutation_p.N28S|ELAVL4_uc001csa.3_Missense_Mutation_p.N45S|ELAVL4_uc001csc.3_Missense_Mutation_p.N28S|ELAVL4_uc009vyu.2_Missense_Mutation_p.N33S|ELAVL4_uc010omz.1_Missense_Mutation_p.N33S	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	28					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						TCCAGCAACAACAGAAACTGT	0.418													12	25					0	0	0	0	G	50610702	G	G	50610702	3	3	219	1	0	0	0	0	1	0	0	0	5076	43	2	5	188	5	ELAVL4	1	50610702	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	14579660	50610702	198639919	5	40142											
FGGY	55277	broad.mit.edu	37	chr1	59812064	59812064	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccccgaaacttctgtggctGaaagaggtgagtgcataggg	10	8	15	8	1	1	3	0	2	1	1	1	4	1	3	2	3	2	2	2	3	3	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:59812064G>C	uc001czi.3	+	4	671	c.459G>C	c.(457-459)CTG>CTC	p.L153L	FGGY_uc001czg.2_Silent_p.L41L|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Silent_p.L153L|FGGY_uc001czj.3_Silent_p.L153L|FGGY_uc001czk.3_Silent_p.L41L|FGGY_uc001czl.3_Intron	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	153					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					TTCTGTGGCTGAAAGAGGTGA	0.498													9	19					0	0	0	0	C	59812064	C	C	59812064	2	2	219	1	0	0	0	0	0	0	0	1	5903	1277	45	2		2	FGGY	1	59812064	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	9201362	59812064	189438557	6	40143											
LEPR	3953	broad.mit.edu	37	chr1	66101886	66101886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttttagccagaaacgtttGagcatctttttatcaagcat	11	16	6	8	1	3	2	1	1	2	1	3	2	3	2	1	0	4	3	1	0	4	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:66101886G>C	uc001dci.2	+	20	2888	c.2686G>C	c.(2686-2688)GAG>CAG	p.E896Q	LEPR_uc009waq.2_Missense_Mutation_p.L169F	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	896	Cytoplasmic (Potential).|Required for JAK2 activation (By similarity).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		AGAAACGTTTGAGCATCTTTT	0.348													29	95					0	0	0	0	C	66101886	C	C	66101886	3	2	219	1	0	0	0	0	1	0	0	0	8768	1291	45	2	2986	2	LEPR	1	66101886	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	6289822	66101886	183148735	7	40144											
FAM40A	85369	broad.mit.edu	37	chr1	110590408	110590408	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccagattgccctcctgaaGatcctgttggctgcagcacc	7	10	9	15	0	0	3	0	1	0	2	3	3	3	3	5	1	3	4	5	1	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	4ed92ac0-e019-4e73-aa69-dacbfc8d2ee1	g.chr1:110590408G>A	uc001dza.1	+	15	1597	c.1578G>A	c.(1576-1578)AAG>AAA	p.K526K	FAM40A_uc001dyz.1_Silent_p.K431K|FAM40A_uc009wfp.1_Silent_p.K350K	NM_033088	NP_149079	Q5VSL9	FA40A_HUMAN	hypothetical protein LOC85369	526						nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)		CCCTCCTGAAGATCCTGTTGG	0.517													5	6					0	0	0	0	A	110590408	A	A	110590408	2	1	219	1	0	0	0	0	0	0	0	1	5592	933	33	2		2	FAM40A	1	110590408	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	44488522	110590408	138660213	8	40145											
HSD3B1	3283	broad.mit.edu	37	chr1	120057080	120057080	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaggccaatttacacctatCgaccgcccttcaaccgccac	10	8	5	18	3	2	0	2	0	0	0	3	1	2	0	6	1	2	0	6	1	4	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:120057080C>T	uc001ehv.1	+	4	1079	c.934C>T	c.(934-936)CGA>TGA	p.R312*	HSD3B1_uc001ehw.2_Nonsense_Mutation_p.R314*	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	312					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	TTACACCTATCGACCGCCCTT	0.473													40	118					0	0	0	0	T	120057080	T	T	120057080	4	4	219	1	0	0	0	0	0	1	0	0	7429	876	31	1	944	1	HSD3B1	1	120057080	Nonsense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	9466672	120057080	129193541	9	40146											
ZNF697	90874	broad.mit.edu	37	chr1	120165638	120165638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agttacgcccgaagcccttcCcgcactcgcggcacacgtag	8	6	10	17	6	0	0	0	0	0	0	2	1	1	0	3	1	2	4	3	1	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:120165638C>T	uc001ehy.1	-	3	1442	c.1328G>A	c.(1327-1329)GGG>GAG	p.G443E		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	443	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		GAAGCCCTTCCCGCACTCGCG	0.667													3	6					0	0	0	0	T	120165638	T	T	120165638	3	4	219	1	0	0	0	0	1	0	0	0	18167	623	22	4	313	4	ZNF697	1	120165638	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	108558	120165638	129084983	10	40147											
SETDB1	9869	broad.mit.edu	37	chr1	150900253	150900253	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctacagtggagtctgaagaGattgcagagctgcaacaggc	12	7	14	8	0	1	3	0	1	1	2	1	5	1	4	0	2	5	4	0	2	3	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:150900253G>A	uc001evu.2	+	2	253	c.63G>A	c.(61-63)GAG>GAA	p.E21E	SETDB1_uc009wmf.2_Silent_p.E21E|SETDB1_uc001evv.2_Silent_p.E21E|SETDB1_uc001evw.3_Silent_p.E21E|SETDB1_uc009wmg.1_Silent_p.E21E	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	21	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGTCTGAAGAGATTGCAGAGC	0.463													17	92					0	0	0	0	A	150900253	A	A	150900253	2	1	219	1	0	0	0	0	0	0	0	1	14203	933	33	2		2	SETDB1	1	150900253	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	30734615	150900253	98350368	11	40148											
FLG	2312	broad.mit.edu	37	chr1	152279854	152279854	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atcctgagtgcccatgggagGcatcagaccttccctgggat	8	9	12	12	0	1	2	1	1	0	1	3	4	3	4	4	3	1	1	4	3	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:152279854G>A	uc001ezu.1	-	3	7544	c.7508C>T	c.(7507-7509)GCC>GTC	p.A2503V		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2503	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCATGGGAGGCATCAGACCT	0.547									Ichthyosis				183	353					0	0	0	0	A	152279854	A	A	152279854	3	1	219	1	0	0	0	0	1	0	0	0	5954	1203	42	4	4681	4	FLG	1	152279854	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1379601	152279854	96970767	12	40149											
CD1D	912	broad.mit.edu	37	chr1	158152778	158152778	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgtatgggtgaagtggatgCggggtgagcaggagcagcag	9	7	20	5	1	0	2	0	2	0	0	0	4	0	4	0	5	4	4	0	5	2	1	rs139209490	by1000genomes	TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	4ed92ac0-e019-4e73-aa69-dacbfc8d2ee1	g.chr1:158152778C>T	uc001frr.2	+	5	1217	c.718C>T	c.(718-720)CGG>TGG	p.R240W	CD1D_uc009wss.2_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	240	Ig-like.|Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					GAAGTGGATGCGGGGTGAGCA	0.632													5	142					0	0	0	0	T	158152778	T	T	158152778	3	4	219	1	0	0	0	0	1	0	0	0	2992	759	27	1	732	1	CD1D	1	158152778	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	5872924	158152778	91097843	13	40150											
OR10R2	343406	broad.mit.edu	37	chr1	158450344	158450344	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attcatttgtggagttcttgTacttgtggttccctttctgt	4	21	9	7	0	3	0	1	0	2	0	4	1	4	1	1	2	1	3	1	2	1	8			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:158450344T>C	uc010pik.1	+	1	677	c.677T>C	c.(676-678)GTA>GCA	p.V226A	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	226	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					GGAGTTCTTGTACTTGTGGTT	0.413													26	87					0	0	0	0	C	158450344	C	C	158450344	3	2	219	1	0	0	0	0	1	0	0	0	10971	1638	57	5	679	5	OR10R2	1	158450344	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	297566	158450344	90800277	14	40151											
PAPPA2	60676	broad.mit.edu	37	chr1	176564443	176564443	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacatcagctggcagctgaGcgtccaccaggtccacaatt	11	7	9	14	1	1	1	1	1	0	0	3	1	3	1	3	2	4	3	3	2	2	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:176564443G>A	uc001gkz.2	+	3	2867	c.1703G>A	c.(1702-1704)AGC>AAC	p.S568N	PAPPA2_uc001gky.1_Missense_Mutation_p.S568N|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	568	Metalloprotease.			S -> N (in Ref. 2; AAL17780).	cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGGCAGCTGAGCGTCCACCAG	0.567													21	81					0	0	0	0	A	176564443	A	A	176564443	3	1	219	1	0	0	0	0	1	0	0	0	11487	971	34	4	1709	4	PAPPA2	1	176564443	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	18114099	176564443	72686178	15	40152											
CEP350	9857	broad.mit.edu	37	chr1	179989427	179989427	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctttgtccagcagaattGaaagtgaagccaagaaatta	15	11	8	7	0	1	4	0	2	1	2	2	4	2	4	2	0	2	1	2	0	6	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:179989427G>C	uc001gnt.2	+	12	2901	c.2518G>C	c.(2518-2520)GAA>CAA	p.E840Q	CEP350_uc009wxl.2_Missense_Mutation_p.E839Q|CEP350_uc001gnu.2_Missense_Mutation_p.E674Q	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	840						centrosome|nucleus|spindle				ovary(4)	4						CAGCAGAATTGAAAGTGAAGC	0.448													57	169					0	0	0	0	C	179989427	C	C	179989427	3	2	219	1	0	0	0	0	1	0	0	0	3269	1291	45	2	2560	2	CEP350	1	179989427	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	3424984	179989427	69261194	16	40153											
ACBD6	84320	broad.mit.edu	37	chr1	180471273	180471273	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagccttctcaaacagctcGgccaggcaactggtctcctc	8	8	9	16	1	2	0	1	0	2	0	6	0	2	0	3	3	4	3	3	3	2	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:180471273G>A	uc001gog.2	-	1	750	c.129C>T	c.(127-129)GCC>GCT	p.A43A		NM_032360	NP_115736	Q9BR61	ACBD6_HUMAN	acyl-coenzyme A binding domain containing 6	43	ACB.					cytoplasm|nucleus	fatty-acyl-CoA binding			ovary(1)	1						CAAACAGCTCGGCCAGGCAAC	0.612													9	33					0	0	0	0	A	180471273	A	A	180471273	2	1	219	1	0	0	0	0	0	0	0	1	126	1103	39	1		1	ACBD6	1	180471273	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	481846	180471273	68779348	17	40154											
GLT25D2	23127	broad.mit.edu	37	chr1	183938459	183938459	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcaaaggtccaggtgtagTcctggtgtggggggtagaaa	10	9	16	6	0	1	1	1	0	0	1	3	1	3	1	2	6	0	2	2	6	4	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:183938459T>G	uc001gqr.2	-	5	1148	c.776A>C	c.(775-777)GAC>GCC	p.D259A	GLT25D2_uc010poj.1_Missense_Mutation_p.D259A|GLT25D2_uc001gqs.2_Missense_Mutation_p.D139A	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	259					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						CCAGGTGTAGTCCTGGTGTGG	0.537													24	71					0	0	0	0	G	183938459	G	G	183938459	3	3	219	1	0	0	0	0	1	0	0	0	6504	1667	58	5	1136	5	GLT25D2	1	183938459	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	3467186	183938459	65312162	18	40155											
F13B	2165	broad.mit.edu	37	chr1	197024886	197024886	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accattttccttgttcgcaaCgagatatttttgatcccctc	8	16	5	12	2	0	2	0	1	0	1	4	3	2	2	4	0	1	2	4	0	2	7			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:197024886C>T	uc001gtt.1	-	8	1357	c.1313G>A	c.(1312-1314)CGT>CAT	p.R438H		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	438	Sushi 7.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTGTTCGCAACGAGATATTTT	0.413													11	53					0	0	0	0	T	197024886	T	T	197024886	3	4	219	1	0	0	0	0	1	0	0	0	5366	536	19	1	692	1	F13B	1	197024886	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	13086427	197024886	52225735	19	40156											
CNTN2	6900	broad.mit.edu	37	chr1	205039107	205039107	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgtccggccctacacgccCtttgaggtcaagatccgcag	8	7	11	15	4	1	2	1	1	0	1	3	2	3	2	4	2	2	1	4	2	2	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:205039107C>A	uc001hbr.2	+	18	2618	c.2349C>A	c.(2347-2349)CCC>CCA	p.P783P	CNTN2_uc001hbq.1_Silent_p.P674P|CNTN2_uc001hbs.2_Silent_p.P571P	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	783	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCTACACGCCCTTTGAGGTCA	0.667													21	82					1.50039e-11	1.65858e-11	1	0	A	205039107	A	A	205039107	2	1	219	1	0	0	0	0	0	0	0	1	3656	668	24	4		4	CNTN2	1	205039107	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	8014221	205039107	44211514	20	40157											
RPS6KC1	26750	broad.mit.edu	37	chr1	213277818	213277818	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatttgatgaaactgttatCgaagagagaagacaatgtgc	15	10	11	5	2	0	5	0	2	0	3	1	8	0	5	0	0	2	1	0	0	5	2	rs56056039	byFrequency	TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:213277818C>A	uc010ptr.1	+	4	444	c.285C>A	c.(283-285)ATC>ATA	p.I95I	RPS6KC1_uc001hkd.2_Silent_p.I83I|RPS6KC1_uc010pts.1_5'UTR|RPS6KC1_uc010ptt.1_5'UTR|RPS6KC1_uc010ptu.1_5'UTR|RPS6KC1_uc010ptv.1_5'UTR|RPS6KC1_uc001hke.2_5'UTR	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	95	PX.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		AAACTGTTATCGAAGAGAGAA	0.373													8	50					3.09899e-07	3.38249e-07	1	0	A	213277818	A	A	213277818	2	1	219	1	0	0	0	0	0	0	0	1	13723	874	31	3		3	RPS6KC1	1	213277818	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	8238711	213277818	35972803	21	40158											
LIN9	286826	broad.mit.edu	37	chr1	226421074	226421074	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taacaaaatagctgtaagccTggaaattaagtctgtcagat	16	11	8	6	0	2	1	1	0	1	1	2	2	2	2	1	1	3	2	1	1	7	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:226421074T>C	uc001hqa.2	-	13	1754	c.1444A>G	c.(1444-1446)AGG>GGG	p.R482G	LIN9_uc001hqb.2_Missense_Mutation_p.R447G|LIN9_uc001hqc.2_Missense_Mutation_p.R414G|LIN9_uc009xel.1_Missense_Mutation_p.R447G	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	466					cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		GCTGTAAGCCTGGAAATTAAG	0.368													3	146					0	0	0	0	C	226421074	C	C	226421074	3	2	219	1	0	0	0	0	1	0	0	0	8855	1579	55	5	244	5	LIN9	1	226421074	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	13143256	226421074	22829547	22	40159											
OBSCN	84033	broad.mit.edu	37	chr1	228495827	228495827	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcagagcctgaggtgaccaTtgtacgggggctggttgatg	7	10	16	8	1	1	4	1	3	0	1	1	4	1	4	2	4	2	3	2	4	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:228495827T>C	uc009xez.1	+	47	12526	c.12482T>C	c.(12481-12483)ATT>ACT	p.I4161T	OBSCN_uc001hsn.2_Missense_Mutation_p.I4161T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4161					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GAGGTGACCATTGTACGGGGG	0.612													14	68					0	0	0	0	C	228495827	C	C	228495827	3	2	219	1	0	0	0	0	1	0	0	0	10866	1493	52	5	12664	5	OBSCN	1	228495827	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	2074753	228495827	20754794	23	40160											
PCNXL2	80003	broad.mit.edu	37	chr1	233394516	233394516	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtagactcagtgggtctccGggttgagaagtatcgatgag	9	11	15	6	2	2	3	1	2	1	2	4	5	2	3	1	2	0	3	1	2	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:233394516G>A	uc001hvl.2	-	5	1327	c.1092C>T	c.(1090-1092)CCC>CCT	p.P364P	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	364						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GTGGGTCTCCGGGTTGAGAAG	0.517													29	119					0	0	0	0	A	233394516	A	A	233394516	2	1	219	1	0	0	0	0	0	0	0	1	11646	1103	39	1		1	PCNXL2	1	233394516	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	4898689	233394516	15856105	24	40161											
IRF2BP2	359948	broad.mit.edu	37	chr1	234745081	234745081	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgagctgccgcgccgtctCgatgacgaactcgacgcggt	6	8	13	14	8	1	2	0	2	1	0	3	5	1	2	2	1	3	1	2	1	1	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:234745081C>A	uc001hwg.2	-	1	191	c.160G>T	c.(160-162)GAG>TAG	p.E54*	IRF2BP2_uc009xfw.2_5'Flank|IRF2BP2_uc001hwf.2_Nonsense_Mutation_p.E54*	NM_182972	NP_892017	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			CGCGCCGTCTCGATGACGAAC	0.746													4	5					0.00116845	0.00125165	1	0	A	234745081	A	A	234745081	4	1	219	1	0	0	0	0	0	1	0	0	7869	893	31	3	1611	3	IRF2BP2	1	234745081	Nonsense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1350565	234745081	14505540	25	40162											
RBM34	23029	broad.mit.edu	37	chr1	235295270	235295270	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagttttctccccatgagttCagaattatttaatttcagag	11	16	7	7	0	3	3	2	1	1	2	4	4	3	3	2	0	0	2	2	0	3	7			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:235295270C>G	uc001hwn.2	-	11	1081	c.1051G>C	c.(1051-1053)GAA>CAA	p.E351Q	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	351	RRM 2.					nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			CCCATGAGTTCAGAATTATTT	0.318													12	43					0	0	0	0	G	235295270	G	G	235295270	3	3	219	1	0	0	0	0	1	0	0	0	13196	835	29	2	245	2	RBM34	1	235295270	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	550189	235295270	13955351	26	40163											
KIF26B	55083	broad.mit.edu	37	chr1	245772637	245772637	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcattccctgtgccatctCttggctcttcaagctcataa	8	14	5	14	0	5	0	3	0	2	0	7	0	6	0	2	1	2	2	2	1	2	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr1:245772637C>G	uc001ibf.1	+	8	2161	c.1721C>G	c.(1720-1722)TCT>TGT	p.S574C	KIF26B_uc010pyq.1_Missense_Mutation_p.S574C|KIF26B_uc001ibg.1_Missense_Mutation_p.S192C	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	574	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			TGTGCCATCTCTTGGCTCTTC	0.537													5	12					0	0	0	0	G	245772637	G	G	245772637	3	3	219	1	0	0	0	0	1	0	0	0	8334	913	32	2	1751	2	KIF26B	1	245772637	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	10477367	245772637	3477984	27	40164											
ALLC	55821	broad.mit.edu	37	chr2	3749215	3749215	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acaagtggaaaccactgcttCcagtgaccaaggttcgtgtg	11	9	11	10	1	0	1	0	1	0	0	2	2	1	2	3	2	2	2	3	2	3	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:3749215C>T	uc010ewt.2	+	11	1125	c.964C>T	c.(964-966)CCA>TCA	p.P322S	ALLC_uc002qyf.2_Missense_Mutation_p.P93S	NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	341							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		ACCACTGCTTCCAGTGACCAA	0.488										HNSCC(21;0.051)			6	13					0	0	0	0	T	3749215	T	T	3749215	3	4	219	1	0	0	0	0	1	0	0	0	534	855	30	2	1002	2	ALLC	2	3749215	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08		3749215	239450158	28	40165											
ZNF513	130557	broad.mit.edu	37	chr2	27601470	27601470	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggtacgctgatgccgcctCaggttgcccaggctgctgca	5	9	14	13	2	1	1	1	1	0	0	1	1	1	1	3	3	5	6	3	3	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:27601470C>T	uc002rkk.2	-	3	863	c.663G>A	c.(661-663)CTG>CTA	p.L221L	ZNF513_uc002rkj.2_Silent_p.L159L	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	221	C2H2-type 3.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATGCCGCCTCAGGTTGCCCA	0.682													15	46					0	0	0	0	T	27601470	T	T	27601470	2	4	219	1	0	0	0	0	0	0	0	1	18025	813	29	2		2	ZNF513	2	27601470	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	23852255	27601470	215597903	29	40166											
BIRC6	57448	broad.mit.edu	37	chr2	32724766	32724766	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaccactatatcacttgctCagacaaagtaatgtcaagaa	16	9	6	10	0	3	2	3	0	0	2	3	2	3	2	1	0	1	3	1	0	6	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:32724766C>G	uc010ezu.2	+	46	8755	c.8621C>G	c.(8620-8622)TCA>TGA	p.S2874*		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2874					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATCACTTGCTCAGACAAAGTA	0.433													44	123					0	0	0	0	G	32724766	G	G	32724766	4	3	219	1	0	0	0	0	0	1	0	0	1441	838	29	2	8803	2	BIRC6	2	32724766	Nonsense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	5123296	32724766	210474607	30	40167											
FANCL	55120	broad.mit.edu	37	chr2	58388764	58388764	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataacaaattccacaatccaTagtaaaatccttcaaaagaa	21	9	2	9	0	1	1	1	0	0	1	4	1	4	1	3	0	1	1	3	0	9	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:58388764T>C	uc002rzw.3	-	12	980	c.913A>G	c.(913-915)ATG>GTG	p.M305V	FANCL_uc002rzx.3_Missense_Mutation_p.M310V|FANCL_uc010fce.2_Missense_Mutation_p.M277V|FANCL_uc010fcf.1_Missense_Mutation_p.M246V	NM_018062	NP_060532	Q9NW38	FANCL_HUMAN	Fanconi anemia, complementation group L isoform	305					DNA repair	cytoplasm|nucleoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CCACAATCCATAGTAAAATCC	0.264								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				2	19					0	0	0	0	C	58388764	C	C	58388764	3	2	219	1	0	0	0	0	1	0	0	0	5702	1406	49	5	226	5	FANCL	2	58388764	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	25663998	58388764	184810609	31	40168											
POLR1A	25885	broad.mit.edu	37	chr2	86267597	86267597	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catctgggtggagggctctcCgatgctctgggcagccagca	6	8	15	12	1	3	0	0	0	3	0	4	2	3	1	2	4	3	4	2	4	0	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:86267597C>T	uc002sqs.2	-	25	4037	c.3658G>A	c.(3658-3660)GGA>AGA	p.G1220R	POLR1A_uc010ytb.1_Missense_Mutation_p.G586R|POLR1A_uc002sqt.1_Missense_Mutation_p.G243R	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1220					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GAGGGCTCTCCGATGCTCTGG	0.627													11	41					0	0	0	0	T	86267597	T	T	86267597	3	4	219	1	0	0	0	0	1	0	0	0	12264	661	23	1	1544	1	POLR1A	2	86267597	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	27878833	86267597	156931776	32	40169											
LONRF2	164832	broad.mit.edu	37	chr2	100916183	100916183	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaacagttcactgacctttCttgggaatttttccaggggc	10	13	9	9	0	2	1	1	1	1	0	3	2	3	2	2	3	1	1	2	3	3	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:100916183C>T	uc002tal.3	-	5	1903	c.1263G>A	c.(1261-1263)AAG>AAA	p.K421K	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	421					proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						ACTGACCTTTCTTGGGAATTT	0.398													22	68					0	0	0	0	T	100916183	T	T	100916183	2	4	219	1	0	0	0	0	0	0	0	1	8945	912	32	2		2	LONRF2	2	100916183	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	14648586	100916183	142283190	33	40170											
SLC5A7	60482	broad.mit.edu	37	chr2	108608589	108608589	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtcggaggagggtatatcaAtggcacagctgaagcagttt	11	9	15	6	1	1	1	1	1	0	0	2	3	1	3	0	5	2	5	0	5	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:108608589A>G	uc002tdv.2	+	3	482	c.206A>G	c.(205-207)AAT>AGT	p.N69S	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.N69S|SLC5A7_uc010ywn.1_5'UTR	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	69	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GGGTATATCAATGGCACAGCT	0.403													16	24					0	0	0	0	G	108608589	G	G	108608589	3	3	219	1	0	0	0	0	1	0	0	0	14734	101	4	5	212	5	SLC5A7	2	108608589	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	7692406	108608589	134590784	34	40171											
CCDC93	54520	broad.mit.edu	37	chr2	118758500	118758500	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaccgagacaattttttctGacagagctctgttcagaaaa	13	11	9	8	1	3	4	1	1	2	3	3	6	3	5	1	1	1	2	1	1	3	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:118758500G>C	uc002tlj.2	-	4	386	c.260C>G	c.(259-261)TCA>TGA	p.S87*	CCDC93_uc010fld.1_Nonsense_Mutation_p.S87*	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	87										large_intestine(1)|ovary(1)	2						AATTTTTTCTGACAGAGCTCT	0.463													14	29					0	0	0	0	C	118758500	C	C	118758500	4	2	219	1	0	0	0	0	0	1	0	0	2885	1294	45	2	1719	2	CCDC93	2	118758500	Nonsense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	10149911	118758500	124440873	35	40172											
LIMS2	55679	broad.mit.edu	37	chr2	128412466	128412466	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcgcagtacttccggcctTcaaactgcaaaggggtcgca	9	9	11	12	3	1	0	1	0	0	0	4	0	2	0	2	3	3	5	2	3	3	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:128412466T>C	uc002tpa.2	-	3	342	c.176A>G	c.(175-177)GAA>GGA	p.E59G	LIMS2_uc002tox.2_Missense_Mutation_p.E83G|LIMS2_uc010fmb.2_5'UTR|LIMS2_uc002toy.2_Missense_Mutation_p.E54G|LIMS2_uc010yzm.1_Missense_Mutation_p.E81G|LIMS2_uc002toz.2_Missense_Mutation_p.E54G|LIMS2_uc002tpb.2_Missense_Mutation_p.E54G	NM_001161403	NP_001154875	Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	59	LIM zinc-binding 1.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		CTTCCGGCCTTCAAACTGCAA	0.582													3	23					0	0	0	0	C	128412466	C	C	128412466	3	2	219	1	0	0	0	0	1	0	0	0	8845	1783	62	5	881	5	LIMS2	2	128412466	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	9653966	128412466	114786907	36	40173											
ACVR1C	130399	broad.mit.edu	37	chr2	158390507	158390507	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagttaggcgggccgctcCgttggcataccaacactcac	9	7	11	14	3	1	0	1	0	0	0	2	0	2	0	3	3	3	5	3	3	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:158390507C>T	uc002tzk.3	-	9	1648	c.1405G>A	c.(1405-1407)GGA>AGA	p.G469R	ACVR1C_uc002tzl.3_Missense_Mutation_p.G389R|ACVR1C_uc010fof.2_Missense_Mutation_p.G312R|ACVR1C_uc010foe.2_Missense_Mutation_p.G419R	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	469	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						CGGGCCGCTCCGTTGGCATAC	0.388													17	109					0	0	0	0	T	158390507	T	T	158390507	3	4	219	1	0	0	0	0	1	0	0	0	222	661	23	1	80	1	ACVR1C	2	158390507	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	29978041	158390507	84808866	37	40174											
TANC1	85461	broad.mit.edu	37	chr2	160086120	160086120	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctctggctgacctgcaaGaggctgtgaaactctgtccc	8	9	11	13	0	2	3	0	2	2	1	3	3	3	3	2	2	3	4	2	2	2	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:160086120G>A	uc002uag.2	+	27	4457	c.4183G>A	c.(4183-4185)GAG>AAG	p.E1395K	TANC1_uc010zcm.1_Silent_p.K1388K|TANC1_uc010fon.2_Missense_Mutation_p.E239K	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1395	TPR 3.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TGACCTGCAAGAGGCTGTGAA	0.473													9	40					0	0	0	0	A	160086120	A	A	160086120	3	1	219	1	0	0	0	0	1	0	0	0	15610	943	33	2	4286	2	TANC1	2	160086120	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1695613	160086120	83113253	38	40175											
LASS6	253782	broad.mit.edu	37	chr2	169417810	169417810	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaggagaagccaagcacgCtgacgaggttctgtgagagc	12	6	14	9	2	2	3	1	2	1	2	2	6	2	3	1	2	3	3	1	2	2	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:169417810C>G	uc002ueb.1	+	3	509	c.385C>G	c.(385-387)CTG>GTG	p.L129V	LASS6_uc002uec.1_Missense_Mutation_p.L129V	NM_203463	NP_982288	Q6ZMG9	CERS6_HUMAN	longevity assurance homolog 6	129	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			skin(1)	1						GCCAAGCACGCTGACGAGGTT	0.448													15	100					0	0	0	0	G	169417810	G	G	169417810	3	3	219	1	0	0	0	0	1	0	0	0	8683	796	28	4	395	4	LASS6	2	169417810	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	9331690	169417810	73781563	39	40176											
DCAF17	80067	broad.mit.edu	37	chr2	172314572	172314572	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagactctatagcttccaaaCcatcgctgaacaggtagaga	14	8	8	11	1	1	3	0	1	1	2	3	4	2	3	2	1	3	3	2	1	5	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:172314572C>A	uc002ugx.2	+	7	948	c.719C>A	c.(718-720)ACC>AAC	p.T240N	DCAF17_uc010zdq.1_RNA|DCAF17_uc010fqf.1_Missense_Mutation_p.T240N|DCAF17_uc010zdr.1_RNA|DCAF17_uc010fqg.2_Intron	NM_025000	NP_079276	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17 isoform 1	240	Helical; (Potential).					CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus					0						AGCTTCCAAACCATCGCTGAA	0.388													81	231					1.21826e-31	1.38657e-31	1	0	A	172314572	A	A	172314572	3	1	219	1	0	0	0	0	1	0	0	0	4286	507	18	4	745	4	DCAF17	2	172314572	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	2896762	172314572	70884801	40	40177											
TTN	7273	broad.mit.edu	37	chr2	179434801	179434801	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caatcagacgcttatggcatCttgtccatctaatgccttct	9	14	6	12	1	4	1	1	0	3	1	5	1	5	1	2	1	1	2	2	1	3	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:179434801C>G	uc010zfg.1	-	275	68578	c.68354G>C	c.(68353-68355)AGA>ACA	p.R22785T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16480T|TTN_uc010zfi.1_Missense_Mutation_p.R16413T|TTN_uc010zfj.1_Missense_Mutation_p.R16288T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23712							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTATGGCATCTTGTCCATCT	0.423													3	141					0	0	0	0	G	179434801	G	G	179434801	3	3	219	1	0	0	0	0	1	0	0	0	16803	913	32	2	32069	2	TTN	2	179434801	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	7120229	179434801	63764572	41	40178											
TTN	7273	broad.mit.edu	37	chr2	179474959	179474959	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagtttgttctcaccagaCatgactggtatatatgttct	10	15	8	8	0	2	2	1	1	2	1	3	3	2	2	1	1	0	4	1	1	3	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:179474959C>T	uc010zfg.1	-	220	43814	c.43590G>A	c.(43588-43590)ATG>ATA	p.M14530I	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.M8225I|TTN_uc010zfi.1_Missense_Mutation_p.M8158I|TTN_uc010zfj.1_Missense_Mutation_p.M8033I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15457							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCACCAGACATGACTGGTA	0.443													144	169					0	0	0	0	T	179474959	T	T	179474959	3	4	219	1	0	0	0	0	1	0	0	0	16803	478	17	4	56767	4	TTN	2	179474959	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	40158	179474959	63724414	42	40179											
TTN	7273	broad.mit.edu	37	chr2	179616442	179616442	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttaatctctaagctggaaGagtgatggtgtaaatcactc	12	14	9	6	0	2	2	1	1	1	1	4	3	2	3	0	2	1	2	0	2	5	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:179616442G>A	uc002unb.2	-	46	10909	c.10685C>T	c.(10684-10686)TCT>TTT	p.S3562F	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAGCTGGAAGAGTGATGGTG	0.423													41	101					0	0	0	0	A	179616442	A	A	179616442	3	1	219	1	0	0	0	0	1	0	0	0	16803	942	33	2	99612	2	TTN	2	179616442	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	141483	179616442	63582931	43	40180											
COL3A1	1281	broad.mit.edu	37	chr2	189864617	189864617	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcccagggaaagatggccCaagggtgagtattcccagtg	10	8	14	9	0	0	2	0	1	0	1	2	3	2	3	3	3	0	1	3	3	3	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:189864617C>G	uc002uqj.1	+	32	2396	c.2279C>G	c.(2278-2280)CCA>CGA	p.P760R		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	760	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AAAGATGGCCCAAGGGTGAGT	0.438													3	19					0	0	0	0	G	189864617	G	G	189864617	3	3	219	1	0	0	0	0	1	0	0	0	3703	594	21	4	2405	4	COL3A1	2	189864617	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	10248175	189864617	53334756	44	40181											
PMS1	5378	broad.mit.edu	37	chr2	190660652	190660653	+	Frame_Shift_Ins	INS	-	G	G																															ggttttcgtggagaagccttINSggggtcaatttgttgtatag																										TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:190660652_190660653insG	uc002urh.3	+	3	819_820	c.290_291insG	c.(289-291)TTGfs	p.L97fs	PMS1_uc010zga.1_Frame_Shift_Ins_p.L97fs|PMS1_uc010zgb.1_Intron|PMS1_uc002urk.3_Frame_Shift_Ins_p.L97fs|PMS1_uc002uri.3_Frame_Shift_Ins_p.L97fs|PMS1_uc010zgc.1_5'UTR|PMS1_uc010zgd.1_Intron|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Frame_Shift_Ins_p.L97fs|PMS1_uc010frz.2_Frame_Shift_Ins_p.L97fs|PMS1_uc010zfz.1_Frame_Shift_Ins_p.L97fs	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	97					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			GGAGAAGCCTTGGGGTCAATTT	0.342			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					---	---	---								G	190660653	G	G	190660652	7	5	219	1	0	1	1	0	0	0	0	0	12197	1821	63	0	296	0	PMS1	2	190660652	Frame_Shift_Ins	INS	-	TCGA-CV-7095-01A-21D-2012-08	796035	190660652	52538721	45	40182											
CASP8	841	broad.mit.edu	37	chr2	202149644	202149644	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatctaccaactcatggAccacagtaacatggactgct	15	8	7	11	0	2	0	1	0	1	0	2	3	2	2	2	2	4	2	2	2	5	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:202149644A>T	uc002uxr.1	+	9	1117	c.908A>T	c.(907-909)GAC>GTC	p.D303V	CASP8_uc002uxp.1_Missense_Mutation_p.D320V|CASP8_uc002uxq.1_Missense_Mutation_p.D288V|CASP8_uc002uxt.1_Missense_Mutation_p.D362V|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Missense_Mutation_p.D288V|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Missense_Mutation_p.D219V	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	303					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CAACTCATGGACCACAGTAAC	0.473										HNSCC(4;0.00038)			81	83					0	0	0	0	T	202149644	T	T	202149644	3	4	219	1	0	0	0	0	1	0	0	0	2689	275	10	5	1215	5	CASP8	2	202149644	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	11488992	202149644	41049729	46	40183											
MARCH4	57574	broad.mit.edu	37	chr2	217124226	217124226	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgcctgcggtctcctcttCcgaggaggggatattggcct	4	11	15	11	2	2	0	0	0	2	0	4	3	3	2	4	6	2	0	4	6	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr2:217124226C>A	uc002vgb.2	-	4	2809	c.1042G>T	c.(1042-1044)GAA>TAA	p.E348*		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	348						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GTCTCCTCTTCCGAGGAGGGG	0.622													18	27					5.35267e-07	5.80571e-07	1	0	A	217124226	A	A	217124226	4	1	219	1	0	0	0	0	0	1	0	0	9356	864	30	2	194	2	MARCH4	2	217124226	Nonsense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	14974582	217124226	26075147	47	40184											
KCNH8	131096	broad.mit.edu	37	chr3	19295208	19295208	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccccatagtctactgttccGatggcttctgcgagcttgct	5	14	9	13	2	2	0	0	0	2	0	4	2	4	0	3	1	4	4	3	1	2	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:19295208G>A	uc003cbk.1	+	2	334	c.139G>A	c.(139-141)GAT>AAT	p.D47N	KCNH8_uc011awe.1_Missense_Mutation_p.D47N|KCNH8_uc010hex.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	47	Cytoplasmic (Potential).|PAS.					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						CTACTGTTCCGATGGCTTCTG	0.453													12	103					0	0	0	0	A	19295208	A	A	19295208	3	1	219	1	0	0	0	0	1	0	0	0	8077	1058	37	1	145	1	KCNH8	3	19295208	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08		19295208	178727222	48	40185											
SLC6A20	54716	broad.mit.edu	37	chr3	45804560	45804560	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacagttgacaaggcacacCagacctgggggccacaagac	13	3	12	13	0	0	3	0	1	0	2	0	3	0	3	3	3	0	3	3	3	2	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:45804560C>G	uc011bai.1	-	9	1432	c.1308G>C	c.(1306-1308)CTG>CTC	p.L436L	SLC6A20_uc003cow.2_Silent_p.L86L|SLC6A20_uc011baj.1_Silent_p.L399L	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	436	Helical; Name=9; (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CAAGGCACACCAGACCTGGGG	0.592													13	55					0	0	0	0	G	45804560	G	G	45804560	2	3	219	1	0	0	0	0	0	0	0	1	14748	581	21	4		4	SLC6A20	3	45804560	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	26509352	45804560	152217870	49	40186											
CACNA1D	776	broad.mit.edu	37	chr3	53757958	53757958	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtttggcggcaagtttaatTttgatgaaacgcaaaccaag	13	12	10	6	2	0	2	0	2	0	0	0	2	0	2	1	2	2	4	1	2	5	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:53757958T>A	uc003dgv.3	+	14	2195	c.2032T>A	c.(2032-2034)TTT>ATT	p.F678I	CACNA1D_uc003dgu.3_Missense_Mutation_p.F698I|CACNA1D_uc003dgy.3_Missense_Mutation_p.F678I|CACNA1D_uc003dgw.3_Missense_Mutation_p.F345I	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	678	Extracellular (Potential).|II.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CAAGTTTAATTTTGATGAAAC	0.463													15	39					0	0	0	0	A	53757958	A	A	53757958	3	1	219	1	0	0	0	0	1	0	0	0	2553	1841	64	5	2258	5	CACNA1D	3	53757958	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	7953398	53757958	144264472	50	40187											
PARP14	54625	broad.mit.edu	37	chr3	122420364	122420364	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgccagatacagctgcccCgccaggtttaccaccagcag	9	6	9	17	1	0	1	0	0	0	1	0	1	0	1	7	1	6	3	7	1	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:122420364C>T	uc003efq.3	+	6	3022	c.2963C>T	c.(2962-2964)CCG>CTG	p.P988L	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.P705L|PARP14_uc003efs.1_Missense_Mutation_p.P705L	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	988					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		ACAGCTGCCCCGCCAGGTTTA	0.522													4	17					0	0	0	0	T	122420364	T	T	122420364	3	4	219	1	0	0	0	0	1	0	0	0	11512	652	23	1	2985	1	PARP14	3	122420364	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	68662406	122420364	75602066	51	40188											
ROPN1B	152015	broad.mit.edu	37	chr3	125694519	125694519	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgttaaagatcctgcattCtcaggtaagggccctgctgc	8	11	11	11	0	1	1	1	0	1	1	3	1	2	1	2	2	3	5	2	2	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:125694519C>G	uc003eih.2	+	3	458	c.230C>G	c.(229-231)TCT>TGT	p.S77C	ROPN1B_uc010hsb.2_Missense_Mutation_p.S77C|ROPN1B_uc010hsc.2_5'UTR|ROPN1B_uc011bkg.1_Missense_Mutation_p.S77C	NM_001012337	NP_001012337	Q9BZX4	ROP1B_HUMAN	ropporin, rhophilin associated protein 1B	77					acrosome reaction|cell-cell adhesion|cytokinesis|fusion of sperm to egg plasma membrane|Rho protein signal transduction|sperm motility|spermatogenesis	cytoplasm|flagellum	cAMP-dependent protein kinase regulator activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling complex scaffold activity				0				GBM - Glioblastoma multiforme(114;0.151)		ATCCTGCATTCTCAGGTAAGG	0.567													18	42					0	0	0	0	G	125694519	G	G	125694519	3	3	219	1	0	0	0	0	1	0	0	0	13589	913	32	2	236	2	ROPN1B	3	125694519	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	3274155	125694519	72327911	52	40189											
PLXNA1	5361	broad.mit.edu	37	chr3	126733043	126733043	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcacctctacaagtgccCggccctgcgcgagagctgcg	7	5	13	16	5	1	1	0	0	1	1	1	2	1	1	3	1	6	2	3	1	2	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:126733043C>T	uc003ejg.2	+	11	2364	c.2360C>T	c.(2359-2361)CCG>CTG	p.P787L		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	810	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		TACAAGTGCCCGGCCCTGCGC	0.736													6	25					0	0	0	0	T	126733043	T	T	126733043	3	4	219	1	0	0	0	0	1	0	0	0	12174	652	23	1	2471	1	PLXNA1	3	126733043	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1038524	126733043	71289387	53	40190											
ASTE1	28990	broad.mit.edu	37	chr3	130744130	130744130	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctatgatcttccacaaaactCattagtcctcggatacccat	12	12	4	13	1	2	1	1	1	1	0	5	2	4	2	3	1	2	0	3	1	5	4	rs139512239		TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:130744130C>G	uc003env.1	-	3	463	c.21G>C	c.(19-21)ATG>ATC	p.M7I	NEK11_uc003enx.2_5'Flank|NEK11_uc003eny.2_5'Flank|NEK11_uc003eoa.2_5'Flank|NEK11_uc003enz.2_5'Flank|NEK11_uc010htn.2_5'Flank|NEK11_uc011blk.1_5'Flank|NEK11_uc011bll.1_5'Flank|NEK11_uc003enw.1_5'Flank|NEK11_uc011blm.1_5'Flank|ASTE1_uc010htm.1_Missense_Mutation_p.M7I|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	7					DNA repair		nuclease activity				0						CCACAAAACTCATTAGTCCTC	0.378													22	57					0	0	0	0	G	130744130	G	G	130744130	3	3	219	1	0	0	0	0	1	0	0	0	1064	826	29	2	2034	2	ASTE1	3	130744130	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	4011087	130744130	67278300	54	40191											
GYG1	2992	broad.mit.edu	37	chr3	148712030	148712030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccaccaggaggctggtcGtgctcgccacccctcaggtc	6	6	13	16	2	1	0	1	0	0	0	4	2	1	2	5	5	1	2	5	5	0	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:148712030G>A	uc003ewn.2	+	2	162	c.109G>A	c.(109-111)GTG>ATG	p.V37M	GYG1_uc011bnp.1_Missense_Mutation_p.V37M|GYG1_uc003ewo.2_Missense_Mutation_p.V37M|GYG1_uc003ewp.2_Missense_Mutation_p.V37M	NM_004130	NP_004121	P46976	GLYG_HUMAN	glycogenin 1	37					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	glycogenin glucosyltransferase activity|metal ion binding|protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GAGGCTGGTCGTGCTCGCCAC	0.587													18	65					0	0	0	0	A	148712030	A	A	148712030	3	1	219	1	0	0	0	0	1	0	0	0	6944	1145	40	1	115	1	GYG1	3	148712030	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	17967900	148712030	49310400	55	40192											
TNIK	23043	broad.mit.edu	37	chr3	170802911	170802911	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcccttcttgcttacctgcGgctgatgattcctcatcctc	4	14	8	15	1	2	2	1	2	1	0	5	2	4	2	4	2	3	2	4	2	1	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:170802911G>A	uc003fhh.2	-	25	3339	c.2994C>T	c.(2992-2994)GCC>GCT	p.A998A	TNIK_uc003fhi.2_Silent_p.A943A|TNIK_uc003fhj.2_Silent_p.A969A|TNIK_uc003fhk.2_Silent_p.A990A|TNIK_uc003fhl.2_Silent_p.A914A|TNIK_uc003fhm.2_Silent_p.A935A|TNIK_uc003fhn.2_Silent_p.A961A|TNIK_uc003fho.2_Silent_p.A906A|TNIK_uc003fhg.2_Silent_p.A176A|TNIK_uc003fhp.2_5'Flank	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	998	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GCTTACCTGCGGCTGATGATT	0.483													3	8					0	0	0	0	A	170802911	A	A	170802911	2	1	219	1	0	0	0	0	0	0	0	1	16379	1103	39	1		1	TNIK	3	170802911	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	22090881	170802911	27219519	56	40193											
PARL	55486	broad.mit.edu	37	chr3	183551318	183551318	+	Frame_Shift_Del	DEL	A	-	-																															ccaagatgtgccgcatgatcAaaaaatttccatcccaggat																										TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:183551318delA	uc003fmd.2	-	9	1049	c.990delT	c.(988-990)TTTfs	p.F330fs	PARL_uc003fme.2_Frame_Shift_Del_p.F280fs	NM_018622	NP_061092	Q9H300	PARL_HUMAN	presenilin associated, rhomboid-like isoform 1	330	Mitochondrial matrix (Potential).				proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity				0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCGCATGATCAAAAAATTTCC	0.473													---	---	---								-	183551318	-	-	183551318	7	5	219	1	0	1	0	1	0	0	0	0	11505	127	5	0	157	0	PARL	3	183551318	Frame_Shift_Del	DEL	A	TCGA-CV-7095-01A-21D-2012-08	12748407	183551318	14471112	57	40194											
IQCG	84223	broad.mit.edu	37	chr3	197670906	197670906	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacttttggaggaaggtttgAgtcttccaggctgtctctaa	9	14	11	7	0	2	1	0	1	2	0	4	3	3	3	1	4	1	2	1	4	3	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr3:197670906A>G	uc003fyo.2	-	3	171	c.25T>C	c.(25-27)TCA>CCA	p.S9P	IQCG_uc003fyp.2_Missense_Mutation_p.S9P|IQCG_uc003fyq.3_Missense_Mutation_p.S9P	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	9											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		GGAAGGTTTGAGTCTTCCAGG	0.408													3	161					0	0	0	0	G	197670906	G	G	197670906	3	3	219	1	0	0	0	0	1	0	0	0	7849	304	11	5	1342	5	IQCG	3	197670906	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	14119588	197670906	351524	58	40195											
DGKQ	1609	broad.mit.edu	37	chr4	959304	959304	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggagtagatgtgactcacGgacaccacggtggctgcaaa	12	6	14	9	2	1	2	1	1	0	1	1	5	1	4	1	4	1	3	1	4	2	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr4:959304G>A	uc003gbw.2	-	14	1667	c.1593C>T	c.(1591-1593)TCC>TCT	p.S531S	DGKQ_uc010ibn.2_Intron	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	531					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TGTGACTCACGGACACCACGG	0.667													5	18					0	0	0	0	A	959304	A	A	959304	2	1	219	1	0	0	0	0	0	0	0	1	4495	1103	39	1		1	DGKQ	4	959304	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08		959304	190194972	59	40196											
IDUA	3425	broad.mit.edu	37	chr4	995557	995557	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccggcgactccttccacaCcccaccgcgatccccgctga	6	5	7	23	5	0	1	0	1	0	0	3	3	3	1	9	1	0	1	9	1	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr4:995557C>G	uc003gby.2	+	6	768	c.680C>G	c.(679-681)ACC>AGC	p.T227S	IDUA_uc003gbz.2_RNA|IDUA_uc003gca.2_Missense_Mutation_p.T180S	NM_000203	NP_000194	P35475	IDUA_HUMAN	alpha-L-iduronidase precursor	227					disaccharide metabolic process	lysosome	cation binding|L-iduronidase activity				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)		Laronidase(DB00090)	TCCTTCCACACCCCACCGCGA	0.711													3	16					0	0	0	0	G	995557	G	G	995557	3	3	219	1	0	0	0	0	1	0	0	0	7543	507	18	4	702	4	IDUA	4	995557	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	36253	995557	190158719	60	40197											
OTOP1	133060	broad.mit.edu	37	chr4	4199228	4199228	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggctctcggtgaatggattCaaagatgaagaggttctgga	12	10	14	5	1	3	4	1	2	2	2	4	6	3	6	0	5	0	2	0	5	3	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr4:4199228C>G	uc003ghp.1	-	5	1363	c.1333G>C	c.(1333-1335)GAA>CAA	p.E445Q		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	445					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGAATGGATTCAAAGATGAAG	0.542													10	62					0	0	0	0	G	4199228	G	G	4199228	3	3	219	1	0	0	0	0	1	0	0	0	11359	835	29	2	513	2	OTOP1	4	4199228	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	3203671	4199228	186955048	61	40198											
EPHA5	2044	broad.mit.edu	37	chr4	66356413	66356413	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aacatttgagatggcattccGaggagcagaggggggtcctg	10	8	16	7	1	0	2	0	1	0	2	2	5	2	3	2	5	2	2	2	5	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr4:66356413G>C	uc003hcy.2	-	5	1277	c.1084C>G	c.(1084-1086)CGG>GGG	p.R362G	EPHA5_uc003hcx.2_Missense_Mutation_p.R293G|EPHA5_uc003hcz.2_Missense_Mutation_p.R362G|EPHA5_uc011cah.1_Missense_Mutation_p.R362G|EPHA5_uc011cai.1_Missense_Mutation_p.R362G|EPHA5_uc003hda.2_Missense_Mutation_p.R362G	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	362	Fibronectin type-III 1.|Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						ATGGCATTCCGAGGAGCAGAG	0.393										TSP Lung(17;0.13)			13	37					0	0	0	0	C	66356413	C	C	66356413	3	2	219	1	0	0	0	0	1	0	0	0	5194	1057	37	3	2085	3	EPHA5	4	66356413	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	62157185	66356413	124797863	62	40199											
SHROOM3	57619	broad.mit.edu	37	chr4	77675521	77675521	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgccgctcttccaccatctCacccctcgttggggtggttc	3	12	9	17	2	2	0	1	0	2	0	6	0	3	0	5	3	1	3	5	3	0	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr4:77675521C>T	uc011cbx.1	+	7	4838	c.3885C>T	c.(3883-3885)CTC>CTT	p.L1295L	SHROOM3_uc003hkg.2_Silent_p.L1073L	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1295					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			TCCACCATCTCACCCCTCGTT	0.542													41	133					0	0	0	0	T	77675521	T	T	77675521	2	4	219	1	0	0	0	0	0	0	0	1	14360	813	29	2		2	SHROOM3	4	77675521	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	11319108	77675521	113478755	63	40200											
FRAS1	80144	broad.mit.edu	37	chr4	79403007	79403007	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtactgacctctctactttCgcatctgtctggtgtgcaac	6	14	9	12	1	3	1	0	1	3	0	5	1	3	1	1	2	4	3	1	2	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr4:79403007C>T	uc003hlb.2	+	57	8933	c.8493C>T	c.(8491-8493)TTC>TTT	p.F2831F		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2826	Calx-beta 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TCTCTACTTTCGCATCTGTCT	0.493													63	180					0	0	0	0	T	79403007	T	T	79403007	2	4	219	1	0	0	0	0	0	0	0	1	6076	883	31	1		1	FRAS1	4	79403007	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1727486	79403007	111751269	64	40201											
FAM190A	401145	broad.mit.edu	37	chr4	91230090	91230090	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagttacacagtaccaagagAgagaacctgtattagtaaga	18	8	9	6	0	0	3	0	0	0	3	0	5	0	3	2	0	3	4	2	0	8	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr4:91230090A>G	uc003hsv.3	+	2	995	c.655A>G	c.(655-657)AGA>GGA	p.R219G	FAM190A_uc003hsu.3_Missense_Mutation_p.R219G|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.R219G	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	219										large_intestine(1)|ovary(1)	2						GTACCAAGAGAGAGAACCTGT	0.408													12	30					0	0	0	0	G	91230090	G	G	91230090	3	3	219	1	0	0	0	0	1	0	0	0	5549	296	11	5	657	5	FAM190A	4	91230090	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	11827083	91230090	99924186	65	40202											
C4orf33	132321	broad.mit.edu	37	chr4	130023861	130023861	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgacagaggagtgatgatGgacattagtgctccattttt	10	13	13	5	0	0	4	0	3	0	1	1	6	1	6	1	3	1	1	1	3	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr4:130023861G>A	uc003igu.3	+	2	460	c.96G>A	c.(94-96)ATG>ATA	p.M32I	C4orf33_uc010ioc.1_Missense_Mutation_p.M32I|C4orf33_uc010iod.2_Missense_Mutation_p.M32I	NM_173487	NP_775758	Q8N1A6	CD033_HUMAN	hypothetical protein LOC132321	32										upper_aerodigestive_tract(1)	1						GAGTGATGATGGACATTAGTG	0.438													13	48					0	0	0	0	A	130023861	A	A	130023861	3	1	219	1	0	0	0	0	1	0	0	0	2273	1348	47	4	98	4	C4orf33	4	130023861	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	38793771	130023861	61130415	66	40203											
FBXW7	55294	broad.mit.edu	37	chr4	153332853	153332853	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgttcctcctctaccacacGattcatctgttcttcatcta	7	16	3	15	1	6	0	2	0	4	0	8	1	8	0	3	0	1	2	3	0	2	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr4:153332853G>A	uc003ims.2	-	2	252	c.103C>T	c.(103-105)CGT>TGT	p.R35C	FBXW7_uc011cii.1_Missense_Mutation_p.R35C|FBXW7_uc003imt.2_Missense_Mutation_p.R35C|FBXW7_uc003imu.2_Missense_Mutation_p.R35C	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	35					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TCTACCACACGATTCATCTGT	0.507			Mis|N|D|F		colorectal|endometrial|T-ALL								47	90					0	0	0	0	A	153332853	A	A	153332853	3	1	219	1	0	0	0	0	1	0	0	0	5801	1058	37	1	2480	1	FBXW7	4	153332853	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	23308992	153332853	37821423	67	40204											
FAT1	2195	broad.mit.edu	37	chr4	187539252	187539252	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcatcagatgccctgatctGaattactctacttccccctg	9	12	6	14	0	3	3	1	2	2	1	4	3	4	3	3	0	4	1	3	0	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr4:187539252G>A	uc003izf.2	-	10	8676	c.8488C>T	c.(8488-8490)CAG>TAG	p.Q2830*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2830	Extracellular (Potential).|Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCCCTGATCTGAATTACTCTA	0.438										HNSCC(5;0.00058)			35	72					0	0	0	0	A	187539252	A	A	187539252	4	1	219	1	0	0	0	0	0	1	0	0	5721	1299	45	2	5350	2	FAT1	4	187539252	Nonsense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	34206399	187539252	3615024	68	40205											
IRX1	79192	broad.mit.edu	37	chr5	3600291	3600291	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcaccttcctgcacctcCaccaccgcagccgccggtcg	5	6	7	23	4	1	0	1	0	0	0	4	0	3	0	9	1	2	2	9	1	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:3600291C>G	uc003jde.2	+	2	1281	c.1229C>G	c.(1228-1230)CCA>CGA	p.P410R		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	410	Poly-Pro.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						CCTGCACCTCCACCACCGCAG	0.701													15	69					0	0	0	0	G	3600291	G	G	3600291	3	3	219	1	0	0	0	0	1	0	0	0	7882	594	21	4	1235	4	IRX1	5	3600291	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08		3600291	177314969	69	40206											
TRIO	7204	broad.mit.edu	37	chr5	14406048	14406048	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaagggagccctgaaggAgcccattcacatccctaaga	12	6	10	13	0	1	3	1	2	0	1	2	5	2	5	4	2	2	0	4	2	3	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:14406048A>G	uc003jff.2	+	32	4814	c.4808A>G	c.(4807-4809)GAG>GGG	p.E1603G	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Missense_Mutation_p.E1252G	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1603					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GCCCTGAAGGAGCCCATTCAC	0.577													10	25					0	0	0	0	G	14406048	G	G	14406048	3	3	219	1	0	0	0	0	1	0	0	0	16619	304	11	5	4934	5	TRIO	5	14406048	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	10805757	14406048	166509212	70	40207											
ZNF622	90441	broad.mit.edu	37	chr5	16465329	16465329	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcctcctttgcaggcgctGggggcgccttcttgggagac	3	10	16	12	2	1	1	0	0	1	1	2	2	2	1	3	5	1	2	3	5	0	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:16465329G>A	uc003jfq.2	-	1	566	c.446C>T	c.(445-447)CCA>CTA	p.P149L		NM_033414	NP_219482	Q969S3	ZN622_HUMAN	zinc finger protein 622	149						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						TGCAGGCGCTGGGGGCGCCTT	0.652													65	92					0	0	0	0	A	16465329	A	A	16465329	3	1	219	1	0	0	0	0	1	0	0	0	18113	1348	47	4	1011	4	ZNF622	5	16465329	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	2059281	16465329	164449931	71	40208											
RANBP3L	202151	broad.mit.edu	37	chr5	36265595	36265595	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactactttgcacaagagctGatgtcataaaaacattgttt	14	13	6	8	0	1	2	1	1	0	1	1	2	1	2	0	0	4	3	0	0	5	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:36265595G>C	uc003jkh.2	-	5	789	c.296C>G	c.(295-297)TCA>TGA	p.S99*	RANBP3L_uc011cow.1_Nonsense_Mutation_p.S124*	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	99					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CACAAGAGCTGATGTCATAAA	0.299													6	32					0	0	0	0	C	36265595	C	C	36265595	4	2	219	1	0	0	0	0	0	1	0	0	13095	1294	45	2	1141	2	RANBP3L	5	36265595	Nonsense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	19800266	36265595	144649665	72	40209											
NIPBL	25836	broad.mit.edu	37	chr5	37048678	37048678	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatataataatattttatctGataagaactcctcagtcaat	16	16	3	6	0	3	2	2	1	1	1	4	2	4	2	1	0	1	0	1	0	9	8			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:37048678G>C	uc003jkl.3	+	39	7163	c.6664G>C	c.(6664-6666)GAT>CAT	p.D2222H	NIPBL_uc003jkk.3_Missense_Mutation_p.D2222H|NIPBL_uc003jkn.2_5'Flank	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2222					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TATTTTATCTGATAAGAACTC	0.363													13	37					0	0	0	0	C	37048678	C	C	37048678	3	2	219	1	0	0	0	0	1	0	0	0	10482	1290	45	2	6814	2	NIPBL	5	37048678	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	783083	37048678	143866582	73	40210											
C6	729	broad.mit.edu	37	chr5	41143093	41143093	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggggcaataggcagacaCatttggaagtggaggctgta	11	8	17	5	0	0	1	0	0	0	1	0	3	0	3	0	6	0	4	0	6	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:41143093C>G	uc003jmk.2	-	18	2849	c.2639G>C	c.(2638-2640)TGT>TCT	p.C880S	C6_uc003jml.1_Missense_Mutation_p.C880S	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	880	Complement control factor I module 2.|C5b-binding domain.|Kazal-like 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TAGGCAGACACATTTGGAAGT	0.458													12	53					0	0	0	0	G	41143093	G	G	41143093	3	3	219	1	0	0	0	0	1	0	0	0	2325	478	17	4	169	4	C6	5	41143093	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	4094415	41143093	139772167	74	40211											
ITGA2	3673	broad.mit.edu	37	chr5	52351412	52351412	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtgggcgacgaagtgctaCgaaagtaatggtagttgtaa	12	10	15	4	3	0	0	0	0	0	0	0	3	0	0	0	3	2	5	0	3	6	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:52351412C>T	uc003joy.2	+	8	967	c.824C>T	c.(823-825)ACG>ATG	p.T275M	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.T199M|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	275	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CGAAGTGCTACGAAAGTAATG	0.373													15	58					0	0	0	0	T	52351412	T	T	52351412	3	4	219	1	0	0	0	0	1	0	0	0	7914	536	19	1	854	1	ITGA2	5	52351412	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	11208319	52351412	128563848	75	40212											
SNCAIP	9627	broad.mit.edu	37	chr5	121761101	121761101	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgacgaaaatggaaacaatCtattacatattgcggcgtca	16	9	8	8	4	2	0	1	0	1	0	2	3	2	1	0	2	3	0	0	2	7	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:121761101C>G	uc003ksw.1	+	5	1263	c.1057C>G	c.(1057-1059)CTA>GTA	p.L353V	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.L353V|SNCAIP_uc003ksx.1_Missense_Mutation_p.L400V|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.L47V|SNCAIP_uc010jcx.1_Intron	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	353	ANK 1.				cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TGGAAACAATCTATTACATAT	0.428													55	54					0	0	0	0	G	121761101	G	G	121761101	3	3	219	1	0	0	0	0	1	0	0	0	14905	912	32	2	1071	2	SNCAIP	5	121761101	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	69409689	121761101	59154159	76	40213											
PCDHB2	56133	broad.mit.edu	37	chr5	140476460	140476460	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccgtctacctggtggtggcgTtggcctcggtgtcttcgctc	1	13	14	13	4	2	0	0	0	2	0	5	0	2	0	3	5	1	2	3	5	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:140476460T>C	uc003lil.2	+	1	2224	c.2086T>C	c.(2086-2088)TTG>CTG	p.L696L	PCDHB2_uc003lim.1_Silent_p.L357L	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	696	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGTGGCGTTGGCCTCGGT	0.697													52	166					0	0	0	0	C	140476460	C	C	140476460	2	2	219	1	0	0	0	0	0	0	0	1	11596	1722	60	5		5	PCDHB2	5	140476460	Silent	SNP	T	TCGA-CV-7095-01A-21D-2012-08	18715359	140476460	40438800	77	40214											
PCDHB3	56132	broad.mit.edu	37	chr5	140482313	140482313	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccgtctacctggtggtggcaTtggcctcggtgtcttcgctc	2	13	13	13	3	2	0	0	0	2	0	5	0	2	0	3	5	1	2	3	5	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:140482313T>C	uc003lio.2	+	1	2080	c.2080T>C	c.(2080-2082)TTG>CTG	p.L694L	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	694	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGTGGCATTGGCCTCGGT	0.687													10	67					0	0	0	0	C	140482313	C	C	140482313	2	2	219	1	0	0	0	0	0	0	0	1	11597	1490	52	5		5	PCDHB3	5	140482313	Silent	SNP	T	TCGA-CV-7095-01A-21D-2012-08	5853	140482313	40432947	78	40215											
PCDHB9	56127	broad.mit.edu	37	chr5	140568971	140568971	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccgtctacctggtggtggcgTtggcctcggtgtcttcgctc	1	13	14	13	4	2	0	0	0	2	0	5	0	2	0	3	5	1	2	3	5	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:140568971T>C	uc003liw.1	+	3	2080	c.2080T>C	c.(2080-2082)TTG>CTG	p.L694L	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	694	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGTGGCGTTGGCCTCGGT	0.706													7	179					0	0	0	0	C	140568971	C	C	140568971	2	2	219	1	0	0	0	0	0	0	0	1	11603	1712	60	5		5	PCDHB9	5	140568971	Silent	SNP	T	TCGA-CV-7095-01A-21D-2012-08	86658	140568971	40346289	79	40216											
PCDHB13	56123	broad.mit.edu	37	chr5	140595775	140595775	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccgtctacctggtggtggcgTtggcctcggtgtcttcgctc	1	13	14	13	4	2	0	0	0	2	0	5	0	2	0	3	5	1	2	3	5	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:140595775T>C	uc003lja.1	+	1	2267	c.2080T>C	c.(2080-2082)TTG>CTG	p.L694L		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	694	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGTGGCGTTGGCCTCGGT	0.682													5	227					0	0	0	0	C	140595775	C	C	140595775	2	2	219	1	0	0	0	0	0	0	0	1	11592	1722	60	5		5	PCDHB13	5	140595775	Silent	SNP	T	TCGA-CV-7095-01A-21D-2012-08	26804	140595775	40319485	80	40217											
ZNF300	91975	broad.mit.edu	37	chr5	150276445	150276445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttaaaatggagcacaatgaaCcatcccttgtgactcctttc	12	12	6	11	0	0	2	0	2	0	0	3	3	2	3	3	1	2	1	3	1	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:150276445C>T	uc003lsy.1	-	6	623	c.356G>A	c.(355-357)GGT>GAT	p.G119D	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCACAATGAACCATCCCTTGT	0.413													26	24					0	0	0	0	T	150276445	T	T	150276445	3	4	219	1	0	0	0	0	1	0	0	0	17898	507	18	4	1462	4	ZNF300	5	150276445	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	9680670	150276445	30638815	81	40218											
FLT4	2324	broad.mit.edu	37	chr5	180047255	180047255	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctcctccagaggcacctcCccggggtccatgatgatgga	7	8	12	14	1	0	3	0	2	0	1	4	4	4	4	6	4	1	2	6	4	0	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr5:180047255C>A	uc003mma.3	-	17	2539	c.2460G>T	c.(2458-2460)GGG>GGT	p.G820G	FLT4_uc003mlz.3_Silent_p.G820G|FLT4_uc003mmb.1_Silent_p.G353G	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	820	Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GAGGCACCTCCCCGGGGTCCA	0.652									Congenital_Hereditary_Lymphedema				49	48					1.86277e-20	2.11318e-20	1	0	A	180047255	A	A	180047255	2	1	219	1	0	0	0	0	0	0	0	1	5976	610	22	4		4	FLT4	5	180047255	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	29770810	180047255	868005	82	40219											
HIST1H2AA	221613	broad.mit.edu	37	chr6	25727627	25727628	+	5'Flank	INS	-	T	T																															gtagtttctaaccgtaagggINSttttttttttttttgaggcg																								rs61603783		TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:25727627_25727628insT	uc003nfc.2	-							NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa						nucleosome assembly	nucleosome|nucleus	DNA binding				0						AACCGTAAGGGttttttttttt	0.203													---	---	---								T	25727628	T	T	25727627	6	5	219	0	1	1	1	0	0	0	0	0	7167	1276	44	0		0	HIST1H2AA	6	25727627	5'Flank	INS	-	TCGA-CV-7095-01A-21D-2012-08		25727627	145387440	83	40220											
OR14J1	442191	broad.mit.edu	37	chr6	29274980	29274980	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctctgtgggaagagagtcAttcaccaattcttctgtgat	9	14	9	9	0	5	2	2	1	3	1	6	4	5	3	1	1	0	0	1	1	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:29274980A>G	uc011dln.1	+	1	514	c.514A>G	c.(514-516)ATT>GTT	p.I172V		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAAGAGAGTCATTCACCAATT	0.478													42	90					0	0	0	0	G	29274980	G	G	29274980	3	3	219	1	0	0	0	0	1	0	0	0	11002	217	8	5	516	5	OR14J1	6	29274980	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	3547353	29274980	141840087	84	40221											
HLA-G	3135	broad.mit.edu	37	chr6	29796372	29796372	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacctggggtccgacggacgCctcctccgcgggtatgaaca	7	6	14	14	5	0	1	0	1	0	0	3	4	3	2	5	4	1	1	5	4	2	1	rs141841160		TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:29796372C>T	uc003nnw.2	+	4	574	c.396C>T	c.(394-396)CGC>CGT	p.R132R	HLA-G_uc011dmb.1_Silent_p.R104R|HLA-G_uc003raj.3_Silent_p.R137R|HLA-G_uc003nnz.3_Intron|HLA-G_uc010jrn.2_Intron|HLA-G_uc003nny.3_Intron|HLA-G_uc003ran.1_5'Flank	NM_002127	NP_002118	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	132	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			ovary(3)|central_nervous_system(1)	4						CCGACGGACGCCTCCTCCGCG	0.672													23	83					0	0	0	0	T	29796372	T	T	29796372	2	4	219	1	0	0	0	0	0	0	0	1	7251	726	26	4		4	HLA-G	6	29796372	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	521392	29796372	141318695	85	40222											
TRIM26	7726	broad.mit.edu	37	chr6	30154334	30154334	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgggtccagggtgacgctCactgtggggacaagggaaaa	10	7	17	7	1	1	1	1	1	0	0	2	3	2	3	1	5	0	1	1	5	3	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:30154334C>T	uc003npr.2	-	9	1148	c.939G>A	c.(937-939)GTG>GTA	p.V313V	TRIM26_uc003nps.2_Silent_p.V313V|TRIM26_uc010jry.2_Silent_p.V43V|TRIM26_uc003npt.2_Silent_p.V313V	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	313	B30.2/SPRY.						DNA binding|zinc ion binding			ovary(2)|lung(1)	3						GGGTGACGCTCACTGTGGGGA	0.468													15	41					0	0	0	0	T	30154334	T	T	30154334	2	4	219	1	0	0	0	0	0	0	0	1	16567	840	29	2		2	TRIM26	6	30154334	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	357962	30154334	140960733	86	40223											
AGPAT1	10554	broad.mit.edu	37	chr6	32137994	32137994	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtttgaagggcagcatggagCcattgtggtttctcgttccc	6	13	13	9	1	1	1	0	1	1	0	3	2	2	2	2	3	2	5	2	3	1	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:32137994C>G	uc003oae.2	-	5	872	c.554G>C	c.(553-555)GGC>GCC	p.G185A	PPT2_uc003nzy.1_Intron|AGPAT1_uc011dpj.1_RNA|AGPAT1_uc011dpk.1_Missense_Mutation_p.G149A|AGPAT1_uc003oaf.2_Missense_Mutation_p.G185A|AGPAT1_uc003oag.2_Missense_Mutation_p.G75A|AGPAT1_uc003oah.2_Missense_Mutation_p.G185A|AGPAT1_uc003oai.1_Missense_Mutation_p.G185A|AGPAT1_uc011dpl.1_Missense_Mutation_p.G73A	NM_006411	NP_006402	Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	185					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)	1						CAGCATGGAGCCATTGTGGTT	0.537													7	12					0	0	0	0	G	32137994	G	G	32137994	3	3	219	1	0	0	0	0	1	0	0	0	386	739	26	4	309	4	AGPAT1	6	32137994	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1983660	32137994	138977073	87	40224											
FTSJD2	23070	broad.mit.edu	37	chr6	37411845	37411845	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagctctgactcttttgaCgatgcattcaaagcagactc	11	11	7	12	1	3	3	1	2	2	1	4	4	3	3	0	0	3	3	0	0	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:37411845C>T	uc003ons.2	+	3	457	c.204C>T	c.(202-204)GAC>GAT	p.D68D	FTSJD2_uc010jwu.2_Silent_p.D68D	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	68					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ACTCTTTTGACGATGCATTCA	0.433													40	52					0	0	0	0	T	37411845	T	T	37411845	2	4	219	1	0	0	0	0	0	0	0	1	6125	535	19	1		1	FTSJD2	6	37411845	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	5273851	37411845	133703222	88	40225											
TTBK1	84630	broad.mit.edu	37	chr6	43214425	43214425	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcctagcggccgcccttaaGgacgaaaccaacatgagtgg	11	6	12	12	3	0	1	0	1	0	0	0	3	0	2	4	3	4	0	4	3	4	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:43214425G>A	uc003ouq.1	+	2	306	c.27G>A	c.(25-27)AAG>AAA	p.K9K		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	9						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCGCCCTTAAGGACGAAACCA	0.672													10	34					0	0	0	0	A	43214425	A	A	43214425	2	1	219	1	0	0	0	0	0	0	0	1	16744	991	35	4		4	TTBK1	6	43214425	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	5802580	43214425	127900642	89	40226											
EYS	346007	broad.mit.edu	37	chr6	66204916	66204916	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagtgtgcattccttttaGtctgcagccaaaaagtaact	13	12	7	9	0	1	0	0	0	1	0	2	0	2	0	2	0	5	3	2	0	5	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:66204916G>T	uc011dxu.1	-	4	926	c.388C>A	c.(388-390)CTA>ATA	p.L130I	EYS_uc003peq.2_Missense_Mutation_p.L130I|EYS_uc003per.1_Missense_Mutation_p.L130I|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	130					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						ATTCCTTTTAGTCTGCAGCCA	0.393													11	23					6.40141e-05	6.89996e-05	1	0	T	66204916	T	T	66204916	3	4	219	1	0	0	0	0	1	0	0	0	5357	1020	36	4	9168	4	EYS	6	66204916	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	22990491	66204916	104910151	90	40227											
PHIP	55023	broad.mit.edu	37	chr6	79655871	79655871	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctgttttaccgtttatctGagcagcattgtgtcttggcg	5	18	10	8	2	3	1	0	1	3	0	3	1	3	1	1	1	3	4	1	1	2	7			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:79655871G>C	uc003pir.2	-	38	4703	c.4477C>G	c.(4477-4479)CAG>GAG	p.Q1493E	PHIP_uc003piq.2_Missense_Mutation_p.Q517E|PHIP_uc011dyp.1_Missense_Mutation_p.Q1492E|IRAK1BP1_uc010kbg.1_RNA|PHIP_uc003pio.3_Missense_Mutation_p.Q379E	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1493					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		CCGTTTATCTGAGCAGCATTG	0.433													7	89					0	0	0	0	C	79655871	C	C	79655871	3	2	219	1	0	0	0	0	1	0	0	0	11897	1299	45	2	1000	2	PHIP	6	79655871	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	13450955	79655871	91459196	91	40228											
LAMA4	3910	broad.mit.edu	37	chr6	112465999	112465999	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcttttcatcagttaccttGctggcaacacttctggtctg	6	16	8	11	0	5	0	2	0	3	0	5	0	5	0	1	2	3	3	1	2	2	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:112465999G>C	uc003pvu.2	-	19	2799	c.2490C>G	c.(2488-2490)AGC>AGG	p.S830R	LAMA4_uc003pvv.2_Missense_Mutation_p.S823R|LAMA4_uc003pvt.2_Missense_Mutation_p.S823R	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	830	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CAGTTACCTTGCTGGCAACAC	0.512													21	82					0	0	0	0	C	112465999	C	C	112465999	3	2	219	1	0	0	0	0	1	0	0	0	8648	1310	46	4	3065	4	LAMA4	6	112465999	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	32810128	112465999	58649068	92	40229											
LAMA2	3908	broad.mit.edu	37	chr6	129635848	129635848	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgccggcctggcaaattcGgactcgatgccaagaatcca	11	7	11	12	3	0	1	0	0	0	1	3	4	1	2	4	3	2	1	4	3	3	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:129635848G>A	uc003qbn.2	+	24	3565	c.3460G>A	c.(3460-3462)GGA>AGA	p.G1154R	LAMA2_uc003qbo.2_Missense_Mutation_p.G1154R	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1154	Laminin EGF-like 13.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGGCAAATTCGGACTCGATGC	0.527													9	37					0	0	0	0	A	129635848	A	A	129635848	3	1	219	1	0	0	0	0	1	0	0	0	8646	1117	39	1	3554	1	LAMA2	6	129635848	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	17169849	129635848	41479219	93	40230											
TCF21	6943	broad.mit.edu	37	chr6	134210544	134210544	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actcccccaaacatgtccacCggctccctcagcgatgtgga	9	7	8	17	2	1	0	1	0	0	0	4	2	4	1	5	2	2	1	5	2	1	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:134210544C>T	uc003qei.3	+	1	285	c.9C>T	c.(7-9)ACC>ACT	p.T3T	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Silent_p.T3T	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	3					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		ACATGTCCACCGGCTCCCTCA	0.338													14	91					0	0	0	0	T	134210544	T	T	134210544	2	4	219	1	0	0	0	0	0	0	0	1	15757	639	23	1		1	TCF21	6	134210544	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	4574696	134210544	36904523	94	40231											
BCLAF1	9774	broad.mit.edu	37	chr6	136582563	136582563	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccacgttgaaaagtaccaCgacctcttcctcttttggcc	8	12	7	14	2	2	1	0	1	2	0	3	2	3	1	5	1	2	2	5	1	3	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:136582563C>T	uc003qgx.1	-	12	2850	c.2597G>A	c.(2596-2598)CGT>CAT	p.R866H	BCLAF1_uc011edb.1_Missense_Mutation_p.R145H|BCLAF1_uc003qgw.1_Missense_Mutation_p.R693H|BCLAF1_uc003qgy.1_Missense_Mutation_p.R815H|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R864H	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	866					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AAAAGTACCACGACCTCTTCC	0.408													25	227					0	0	0	0	T	136582563	T	T	136582563	3	4	219	1	0	0	0	0	1	0	0	0	1385	536	19	1	173	1	BCLAF1	6	136582563	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	2372019	136582563	34532504	95	40232											
SHPRH	257218	broad.mit.edu	37	chr6	146245960	146245960	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtattacacttgctcatgTagtgctctcgcagctgtttg	6	16	9	10	1	2	0	1	0	1	0	3	0	2	0	0	0	4	7	0	0	3	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:146245960T>A	uc003qlf.2	-	17	3716	c.3317A>T	c.(3316-3318)TAC>TTC	p.Y1106F	SHPRH_uc003qld.2_Missense_Mutation_p.Y1115F|SHPRH_uc003qle.2_Missense_Mutation_p.Y1115F|SHPRH_uc003qlg.1_Missense_Mutation_p.Y662F|SHPRH_uc003qlh.2_Missense_Mutation_p.Y31F|SHPRH_uc003qli.1_Missense_Mutation_p.Y31F	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1106					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CTTGCTCATGTAGTGCTCTCG	0.408													23	59					0	0	0	0	A	146245960	A	A	146245960	3	1	219	1	0	0	0	0	1	0	0	0	14356	1638	57	5	1807	5	SHPRH	6	146245960	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	9663397	146245960	24869107	96	40233											
SYNE1	23345	broad.mit.edu	37	chr6	152763311	152763311	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggtcaggcagccccccttCtccctgctgcgcctgcgcga	3	8	11	19	4	2	0	1	0	1	0	4	1	2	0	5	2	4	2	5	2	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr6:152763311C>T	uc010kiw.2	-	31	4509	c.3907G>A	c.(3907-3909)GAA>AAA	p.E1303K	SYNE1_uc003qot.3_Missense_Mutation_p.E1310K|SYNE1_uc003qou.3_Missense_Mutation_p.E1303K|SYNE1_uc010kjb.1_Missense_Mutation_p.E1286K|SYNE1_uc003qow.2_Missense_Mutation_p.E598K|SYNE1_uc003qox.1_Missense_Mutation_p.E819K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1303	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGCCCCCCTTCTCCCTGCTGC	0.582										HNSCC(10;0.0054)			18	60					0	0	0	0	T	152763311	T	T	152763311	3	4	219	1	0	0	0	0	1	0	0	0	15511	922	32	2	23023	2	SYNE1	6	152763311	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	6517351	152763311	18351756	97	40234											
CYP2W1	54905	broad.mit.edu	37	chr7	1026752	1026752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcctctgcagggggatgacCccgagggcctgtttgctgag	5	8	16	12	2	1	2	0	2	1	0	1	4	1	3	4	3	2	3	4	3	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:1026752C>T	uc003sjq.1	+	6	842	c.829C>T	c.(829-831)CCC>TCC	p.P277S	CYP2W1_uc003sjr.1_Missense_Mutation_p.P277S	NM_017781	NP_060251	Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W,	277					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GGGGGATGACCCCGAGGGCCT	0.692													5	7					0	0	0	0	T	1026752	T	T	1026752	3	4	219	1	0	0	0	0	1	0	0	0	4193	623	22	4	851	4	CYP2W1	7	1026752	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08		1026752	158111911	98	40235											
RADIL	55698	broad.mit.edu	37	chr7	4856042	4856042	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgaggaccagctctcacggcGctccgtctggaatggcgggc	6	6	15	14	5	2	0	1	0	2	0	4	3	3	2	2	5	1	2	2	5	1	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:4856042G>A	uc003snj.1	-	8	1956	c.1783C>T	c.(1783-1785)CGC>TGC	p.R595C	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Missense_Mutation_p.R100C|RADIL_uc011jwc.1_Missense_Mutation_p.R355C|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	595	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CTCTCACGGCGCTCCGTCTGG	0.677													4	15					0	0	0	0	A	4856042	A	A	4856042	3	1	219	1	0	0	0	0	1	0	0	0	13062	1087	38	1	1476	1	RADIL	7	4856042	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	3829290	4856042	154282621	99	40236											
DNAH11	8701	broad.mit.edu	37	chr7	21646281	21646281	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggcaaagcaggcagagtTcagagagagattcagacact	15	6	12	8	0	3	4	3	0	0	4	3	6	3	4	0	2	1	4	0	2	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:21646281T>C	uc003svc.2	+	20	3813	c.3782T>C	c.(3781-3783)TTC>TCC	p.F1261S		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1261	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CAGGCAGAGTTCAGAGAGAGA	0.338									Kartagener_syndrome				3	10					0	0	0	0	C	21646281	C	C	21646281	3	2	219	1	0	0	0	0	1	0	0	0	4621	1783	62	5	3860	5	DNAH11	7	21646281	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	16790239	21646281	137492382	100	40237											
PCLO	27445	broad.mit.edu	37	chr7	82579179	82579179	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagatattgaggactttgTgtgtctgaatctgcttctgt	7	17	10	7	0	4	3	1	2	3	1	4	4	4	4	0	1	1	1	0	1	2	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:82579179T>A	uc003uhx.2	-	6	11014	c.10725A>T	c.(10723-10725)ACA>ACT	p.T3575T	PCLO_uc003uhv.2_Silent_p.T3575T|PCLO_uc010lec.2_Silent_p.T540T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3506					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GAGGACTTTGTGTGTCTGAAT	0.438													18	48					0	0	0	0	A	82579179	A	A	82579179	2	1	219	1	0	0	0	0	0	0	0	1	11637	1683	59	5		5	PCLO	7	82579179	Silent	SNP	T	TCGA-CV-7095-01A-21D-2012-08	60932898	82579179	76559484	101	40238											
LMTK2	22853	broad.mit.edu	37	chr7	97832936	97832936	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaggagaggcgtgcggcccGgacctgagcggcccagcccc	6	2	18	15	4	0	2	0	1	0	1	0	5	0	4	5	6	3	0	5	6	0	0	rs146973469	byFrequency	TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:97832936G>A	uc003upd.1	+	12	4451	c.4158G>A	c.(4156-4158)CCG>CCA	p.P1386P		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	1386					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CGTGCGGCCCGGACCTGAGCG	0.597													11	26					0	0	0	0	A	97832936	A	A	97832936	2	1	219	1	0	0	0	0	0	0	0	1	8901	1103	39	1		1	LMTK2	7	97832936	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	15253757	97832936	61305727	102	40239											
BAIAP2L1	55971	broad.mit.edu	37	chr7	97935815	97935815	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caacttcgtgtacgacgacgGgaaccaacccctcctaccgg	10	6	9	16	5	0	0	0	0	0	0	2	3	1	1	5	2	5	1	5	2	5	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:97935815G>A	uc003upj.2	-	11	1440	c.1177C>T	c.(1177-1179)CCG>TCG	p.P393S	uc003upk.1_5'Flank	NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	393	SH3.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			TACGACGACGGGAACCAACCC	0.572													25	71					0	0	0	0	A	97935815	A	A	97935815	3	1	219	1	0	0	0	0	1	0	0	0	1304	1232	43	4	374	4	BAIAP2L1	7	97935815	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	102879	97935815	61202848	103	40240											
PUS7	54517	broad.mit.edu	37	chr7	105098338	105098338	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcgtaagtagaagggggtaGagaaaaatccattttcagag	15	8	14	4	1	1	3	1	0	0	3	2	4	2	3	1	3	0	3	1	3	6	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:105098338G>C	uc003vcx.2	-	16	2104	c.1885C>G	c.(1885-1887)CTA>GTA	p.L629V	PUS7_uc010lji.2_Missense_Mutation_p.L635V|PUS7_uc003vcy.2_Missense_Mutation_p.L629V|PUS7_uc003vcz.1_Missense_Mutation_p.L629V	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	629					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						GAAGGGGGTAGAGAAAAATCC	0.473													32	88					0	0	0	0	C	105098338	C	C	105098338	3	2	219	1	0	0	0	0	1	0	0	0	12898	933	33	2	104	2	PUS7	7	105098338	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	7162523	105098338	54040325	104	40241											
COG5	10466	broad.mit.edu	37	chr7	107204296	107204296	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgcagccgctccagagcctcGagctccgaggccagctacag	8	5	12	16	3	0	1	0	0	0	1	3	3	2	1	5	1	6	4	5	1	1	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:107204296G>C	uc003ved.2	-	1	664	c.139C>G	c.(139-141)CGA>GGA	p.R47G	COG5_uc003vec.2_Missense_Mutation_p.R47G|COG5_uc003vee.2_Missense_Mutation_p.R47G|DUS4L_uc003veg.2_5'Flank|DUS4L_uc003veh.2_5'Flank|DUS4L_uc011klw.1_5'Flank|DUS4L_uc011klx.1_5'Flank	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	47					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						CCAGAGCCTCGAGCTCCGAGG	0.667													28	50					0	0	0	0	C	107204296	C	C	107204296	3	2	219	1	0	0	0	0	1	0	0	0	3676	1066	37	3	2535	3	COG5	7	107204296	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	2105958	107204296	51934367	105	40242											
CBLL1	79872	broad.mit.edu	37	chr7	107398754	107398754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgttacccgtgcttcacttGaaaatgttcatcctcctatt	8	16	5	12	1	2	1	2	1	0	0	4	1	4	1	3	0	2	3	3	0	4	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:107398754G>A	uc003veq.2	+	6	937	c.607G>A	c.(607-609)GAA>AAA	p.E203K	CBLL1_uc011kme.1_Missense_Mutation_p.E82K|CBLL1_uc011kmf.1_Missense_Mutation_p.E202K	NM_024814	NP_079090	Q75N03	HAKAI_HUMAN	Cas-Br-M (murine) ecotropic retroviral	203					cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|skin(2)|lung(1)	5						TGCTTCACTTGAAAATGTTCA	0.458													57	125					0	0	0	0	A	107398754	A	A	107398754	3	1	219	1	0	0	0	0	1	0	0	0	2715	1291	45	2	629	2	CBLL1	7	107398754	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	194458	107398754	51739909	106	40243											
CTTNBP2	83992	broad.mit.edu	37	chr7	117432019	117432019	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggagctatgcctggtgtttGagcggtgggaggggcagcgt	6	9	20	6	2	0	1	0	1	0	0	0	3	0	3	1	6	4	3	1	6	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:117432019G>C	uc003vjf.2	-	4	1323	c.1231C>G	c.(1231-1233)CAA>GAA	p.Q411E		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	411	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CCTGGTGTTTGAGCGGTGGGA	0.522													34	115					0	0	0	0	C	117432019	C	C	117432019	3	2	219	1	0	0	0	0	1	0	0	0	4062	1299	45	2	3840	2	CTTNBP2	7	117432019	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	10033265	117432019	41706644	107	40244											
TAS2R16	50833	broad.mit.edu	37	chr7	122635216	122635216	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtttcttggtagatgcTccatggtgagtaactgaatt	8	16	11	6	0	1	3	0	2	1	1	2	3	2	3	1	2	3	5	1	2	3	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:122635216T>C	uc003vkl.1	-	1	539	c.473A>G	c.(472-474)GAG>GGG	p.E158G		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	158	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						TGGTAGATGCTCCATGGTGAG	0.383													13	46					0	0	0	0	C	122635216	C	C	122635216	3	2	219	1	0	0	0	0	1	0	0	0	15635	1551	54	5	406	5	TAS2R16	7	122635216	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	5203197	122635216	36503447	108	40245											
JHDM1D	80853	broad.mit.edu	37	chr7	139796488	139796488	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttgcctttgtaaacacgtGgaatagtgcaaccctgccat	11	12	8	10	1	0	0	0	0	0	0	0	1	0	1	3	1	5	2	3	1	5	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:139796488G>A	uc003vvm.2	-	17	2245	c.2241C>T	c.(2239-2241)TCC>TCT	p.S747S	JHDM1D_uc010lng.2_RNA	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	747					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					GTAAACACGTGGAATAGTGCA	0.483													23	64					0	0	0	0	A	139796488	A	A	139796488	2	1	219	1	0	0	0	0	0	0	0	1	7987	1335	47	4		4	JHDM1D	7	139796488	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	17161272	139796488	19342175	109	40246											
OR9A4	130075	broad.mit.edu	37	chr7	141619579	141619579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ataaagtcatagaggcccttCgggatggggtgaaacgctgc	11	8	14	8	2	1	2	1	1	0	1	2	3	1	3	1	4	2	1	1	4	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:141619579C>T	uc003vwu.1	+	1	904	c.904C>T	c.(904-906)CGG>TGG	p.R302W		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					AGAGGCCCTTCGGGATGGGGT	0.423													21	70					0	0	0	0	T	141619579	T	T	141619579	3	4	219	1	0	0	0	0	1	0	0	0	11303	875	31	1	906	1	OR9A4	7	141619579	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1823091	141619579	17519084	110	40247											
EPHB6	2051	broad.mit.edu	37	chr7	142566409	142566409	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagcaccccaacatcctgcGgctggagggcgtggtcacca	8	5	12	16	2	1	0	1	0	0	0	2	1	2	1	5	4	3	2	5	4	1	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:142566409G>A	uc011kst.1	+	15	2985	c.2198G>A	c.(2197-2199)CGG>CAG	p.R733Q	EPHB6_uc011ksu.1_Missense_Mutation_p.R733Q|EPHB6_uc003wbs.2_Missense_Mutation_p.R441Q|EPHB6_uc003wbt.2_Missense_Mutation_p.R207Q|EPHB6_uc003wbu.2_Missense_Mutation_p.R441Q|EPHB6_uc003wbv.2_Missense_Mutation_p.R117Q	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	733	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					AACATCCTGCGGCTGGAGGGC	0.677													21	36					0	0	0	0	A	142566409	A	A	142566409	3	1	219	1	0	0	0	0	1	0	0	0	5202	1116	39	1	2240	1	EPHB6	7	142566409	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	946830	142566409	16572254	111	40248											
CNTNAP2	26047	broad.mit.edu	37	chr7	147336299	147336299	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacacagctcgtttacagcGcctccatggaccagataagt	11	9	9	12	2	0	2	0	1	0	1	2	3	1	3	3	1	3	2	3	1	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:147336299G>A	uc003weu.1	+	13	2515	c.1999G>A	c.(1999-2001)GCC>ACC	p.A667T		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	667	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.A667T(1)		ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CGTTTACAGCGCCTCCATGGA	0.502										HNSCC(39;0.1)			18	49					0	0	0	0	A	147336299	A	A	147336299	3	1	219	1	0	0	0	0	1	0	0	0	3662	1087	38	1	2049	1	CNTNAP2	7	147336299	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	4769890	147336299	11802364	112	40249											
C7orf33	202865	broad.mit.edu	37	chr7	148288041	148288041	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caagtggaagttcaaagcctCagccttgaagagtgtccctg	11	9	11	10	0	2	2	2	1	0	1	3	3	3	3	3	1	2	1	3	1	4	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr7:148288041C>G	uc003wew.2	+	1	385	c.24C>G	c.(22-24)CTC>CTG	p.L8L		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	8										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TTCAAAGCCTCAGCCTTGAAG	0.537													10	65					0	0	0	0	G	148288041	G	G	148288041	2	3	219	1	0	0	0	0	0	0	0	1	2399	813	29	2		2	C7orf33	7	148288041	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	951742	148288041	10850622	113	40250											
UNC5D	137970	broad.mit.edu	37	chr8	35583721	35583721	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagatctgacagtgagccGgacatacagcggacccatct	11	6	11	13	2	2	3	0	2	2	1	2	5	2	5	3	2	3	0	3	2	1	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr8:35583721G>A	uc003xjr.1	+	10	1683	c.1355G>A	c.(1354-1356)CGG>CAG	p.R452Q	UNC5D_uc003xjs.1_Missense_Mutation_p.R447Q|UNC5D_uc003xju.1_Missense_Mutation_p.R28Q|UNC5D_uc003xjt.1_Missense_Mutation_p.R210Q	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	452	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		ACAGTGAGCCGGACATACAGC	0.488													59	62					0	0	0	0	A	35583721	A	A	35583721	3	1	219	1	0	0	0	0	1	0	0	0	17063	1116	39	1	1393	1	UNC5D	8	35583721	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08		35583721	110780301	114	40251											
KCNU1	157855	broad.mit.edu	37	chr8	36671785	36671785	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagaatatatcatattttGagtcaatttacctggtcatg	13	15	6	7	0	3	2	3	1	0	1	3	2	3	2	1	1	1	0	1	1	6	7			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr8:36671785G>A	uc010lvw.2	+	8	880	c.793G>A	c.(793-795)GAG>AAG	p.E265K	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	265						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ATCATATTTTGAGTCAATTTA	0.418													17	18					0	0	0	0	A	36671785	A	A	36671785	3	1	219	1	0	0	0	0	1	0	0	0	8132	1291	45	2	823	2	KCNU1	8	36671785	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1088064	36671785	109692237	115	40252											
PLEKHA2	59339	broad.mit.edu	37	chr8	38810819	38810819	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttctttccaccaggaccGagaaccactgcgcaccatat	10	9	7	15	2	1	1	0	0	1	1	2	3	2	2	5	1	2	2	5	1	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr8:38810819G>T	uc003xmi.3	+	9	941	c.707G>T	c.(706-708)CGA>CTA	p.R236L	PLEKHA2_uc011lce.1_Missense_Mutation_p.R186L	NM_021623	NP_067636	Q9HB19	PKHA2_HUMAN	pleckstrin homology domain containing, family A	236	PH 2.				positive regulation of cell-matrix adhesion	cytoplasm|nucleus|plasma membrane|protein complex	fibronectin binding|laminin binding				0		all_lung(54;0.0413)|Lung NSC(58;0.115)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;4.68e-08)|COAD - Colon adenocarcinoma(9;0.235)			CACCAGGACCGAGAACCACTG	0.463													87	224					2.16659e-41	2.47406e-41	1	0	T	38810819	T	T	38810819	3	4	219	1	0	0	0	0	1	0	0	0	12111	1058	37	3	737	3	PLEKHA2	8	38810819	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	2139034	38810819	107553203	116	40253											
CPA6	57094	broad.mit.edu	37	chr8	68334861	68334861	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atatccagtgtcacgtagttCgaaagcaaatgcataaggta	15	10	9	7	2	1	0	1	0	0	0	3	1	2	0	1	1	2	5	1	1	6	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr8:68334861C>T	uc003xxq.3	-	11	1448	c.1192G>A	c.(1192-1194)GAA>AAA	p.E398K	CPA6_uc003xxr.3_Missense_Mutation_p.E154K	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	398		Nucleophile (By similarity).			proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			TCACGTAGTTCGAAAGCAAAT	0.383													38	94					0	0	0	0	T	68334861	T	T	68334861	3	4	219	1	0	0	0	0	1	0	0	0	3809	893	31	1	125	1	CPA6	8	68334861	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	29524042	68334861	78029161	117	40254											
COL14A1	7373	broad.mit.edu	37	chr8	121290786	121290786	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaagatcacaagatgatgtGaacaaaatctccagggagat	17	7	11	6	0	2	5	1	2	1	3	3	7	2	6	1	2	1	0	1	2	5	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr8:121290786G>C	uc003yox.2	+	28	3715	c.3450G>C	c.(3448-3450)GTG>GTC	p.V1150V	COL14A1_uc003yoz.2_Silent_p.V115V	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1150	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AAGATGATGTGAACAAAATCT	0.353													18	18					0	0	0	0	C	121290786	C	C	121290786	2	2	219	1	0	0	0	0	0	0	0	1	3686	1277	45	2		2	COL14A1	8	121290786	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	52955925	121290786	25073236	118	40255											
PLEC	5339	broad.mit.edu	37	chr8	144998292	144998292	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccttgccagcggccgccttCtcgaagctcgccttcagcgc	4	8	11	18	5	2	0	1	0	1	0	4	1	2	0	5	1	4	1	5	1	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr8:144998292C>T	uc003zaf.1	-	31	6386	c.6216G>A	c.(6214-6216)GAG>GAA	p.E2072E	PLEC_uc003zab.1_Silent_p.E1935E|PLEC_uc003zac.1_Silent_p.E1939E|PLEC_uc003zad.2_Silent_p.E1935E|PLEC_uc003zae.1_Silent_p.E1903E|PLEC_uc003zag.1_Silent_p.E1913E|PLEC_uc003zah.2_Silent_p.E1921E|PLEC_uc003zaj.2_Silent_p.E1962E	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2072	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGGCCGCCTTCTCGAAGCTCG	0.701													15	28					0	0	0	0	T	144998292	T	T	144998292	2	4	219	1	0	0	0	0	0	0	0	1	12107	912	32	2		2	PLEC	8	144998292	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	23707506	144998292	1365730	119	40256											
GLIS3	169792	broad.mit.edu	37	chr9	3937164	3937164	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttgagattttcaagccttGaaaaggccttctcgcaacct	10	13	7	11	1	3	2	1	2	2	1	4	3	3	2	3	1	2	1	3	1	4	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:3937164G>A	uc003zhw.1	-	4	1465	c.1271C>T	c.(1270-1272)TCA>TTA	p.S424L	GLIS3_uc003zhx.1_Missense_Mutation_p.S579L|GLIS3_uc010mhf.1_5'UTR|GLIS3_uc003zhv.1_RNA|GLIS3_uc003zhy.1_Missense_Mutation_p.S357L|GLIS3_uc003zhz.1_Missense_Mutation_p.S357L	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	424	C2H2-type 3.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		TTCAAGCCTTGAAAAGGCCTT	0.458													9	69					0	0	0	0	A	3937164	A	A	3937164	3	1	219	1	0	0	0	0	1	0	0	0	6484	1294	45	2	1084	2	GLIS3	9	3937164	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08		3937164	137276267	120	40257											
FREM1	158326	broad.mit.edu	37	chr9	14848678	14848678	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttacctgtattccaggataCacggggggcatttgtatctg	8	14	11	8	1	1	0	0	0	1	0	2	1	2	1	2	4	2	3	2	4	4	7			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:14848678C>A	uc003zlm.2	-	7	1836	c.1246G>T	c.(1246-1248)GTA>TTA	p.V416L	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	416	CSPG 2.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TTCCAGGATACACGGGGGGCA	0.373													19	42					1.28384e-07	1.40572e-07	1	0	A	14848678	A	A	14848678	3	1	219	1	0	0	0	0	1	0	0	0	6078	478	17	4	5467	4	FREM1	9	14848678	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	10911514	14848678	126364753	121	40258											
UNC13B	10497	broad.mit.edu	37	chr9	35385812	35385812	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tactttcttcagaatgaaggTaagaaatggactggggcttg	12	12	12	5	0	2	3	1	1	1	2	2	4	2	4	0	4	1	2	0	4	5	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:35385812T>C	uc003zwq.2	+	22	3010	c.2718_splice	c.e22+2	p.K906_splice	UNC13B_uc003zwr.2_Splice_Site_p.K906_splice	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like						excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			AGAATGAAGGTAAGAAATGGA	0.483													27	97					0	0	0	0	C	35385812	C	C	35385812	5	2	219	1	0	0	0	0	0	0	1	0	17053	1652	57	5	2806	5	UNC13B	9	35385812	Splice_Site	SNP	T	TCGA-CV-7095-01A-21D-2012-08	20537134	35385812	105827619	122	40259											
UNC13B	10497	broad.mit.edu	37	chr9	35403456	35403456	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtggctgccaatgacctCaagtggcagacagcgggtat	9	8	15	9	1	1	2	1	1	0	1	1	2	1	2	2	4	2	3	2	4	3	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:35403456C>T	uc003zwq.2	+	38	4642	c.4350C>T	c.(4348-4350)CTC>CTT	p.L1450L	UNC13B_uc003zwr.2_Silent_p.L1469L	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	1450	C2 3.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			CCAATGACCTCAAGTGGCAGA	0.532													27	47					0	0	0	0	T	35403456	T	T	35403456	2	4	219	1	0	0	0	0	0	0	0	1	17053	813	29	2		2	UNC13B	9	35403456	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	17644	35403456	105809975	123	40260											
RGP1	9827	broad.mit.edu	37	chr9	35750328	35750328	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctcctcctgactctagtCagccagatgtccagcccgac	7	9	8	17	1	2	2	1	1	1	1	5	3	5	2	6	0	3	0	6	0	1	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:35750328C>A	uc011lpf.1	+	3	346	c.205C>A	c.(205-207)CAG>AAG	p.Q69K	GBA2_uc011lpb.1_5'Flank|GBA2_uc003zxw.2_5'Flank|GBA2_uc011lpc.1_5'Flank|GBA2_uc011lpd.1_5'Flank|RGP1_uc011lpe.1_Missense_Mutation_p.Q109K	NM_001080496	NP_001073965	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog	69										ovary(1)	1	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGACTCTAGTCAGCCAGATGT	0.612													9	31					9.05144e-12	1.00378e-11	1	0	A	35750328	A	A	35750328	3	1	219	1	0	0	0	0	1	0	0	0	13349	827	29	2	339	2	RGP1	9	35750328	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	346872	35750328	105463103	124	40261											
VPS13A	23230	broad.mit.edu	37	chr9	79910535	79910535	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagctggaatggctgctacTggtgtaaaagaactcgcaca	12	8	12	9	1	0	1	0	0	0	1	1	2	0	2	0	3	4	6	0	3	5	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:79910535T>G	uc004akr.2	+	33	3845	c.3585T>G	c.(3583-3585)ACT>ACG	p.T1195T	VPS13A_uc004akp.3_Silent_p.T1195T|VPS13A_uc004akq.3_Silent_p.T1195T|VPS13A_uc004aks.2_Silent_p.T1156T|VPS13A_uc010mpo.1_5'UTR	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1195					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						TGGCTGCTACTGGTGTAAAAG	0.433													9	50					0	0	0	0	G	79910535	G	G	79910535	2	3	219	1	0	0	0	0	0	0	0	1	17257	1567	55	5		5	VPS13A	9	79910535	Silent	SNP	T	TCGA-CV-7095-01A-21D-2012-08	44160207	79910535	61302896	125	40262											
AGTPBP1	23287	broad.mit.edu	37	chr9	88307677	88307677	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattctgaaggctcagcattGatcttctccagttgagccag	9	12	10	10	0	4	3	1	3	3	0	5	4	4	3	2	1	2	3	2	1	1	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:88307677G>C	uc011ltd.1	-	2	117	c.84C>G	c.(82-84)ATC>ATG	p.I28M	AGTPBP1_uc010mqc.2_Missense_Mutation_p.I28M|AGTPBP1_uc011lte.1_Missense_Mutation_p.I80M	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	28					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						GCTCAGCATTGATCTTCTCCA	0.388													6	25					0	0	0	0	C	88307677	C	C	88307677	3	2	219	1	0	0	0	0	1	0	0	0	400	1280	45	2	3572	2	AGTPBP1	9	88307677	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	8397142	88307677	52905754	126	40263											
SLC31A1	1317	broad.mit.edu	37	chr9	116028637	116028637	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtagaactgatgattcaagAggctcttatgatcacagctg	12	11	10	8	1	3	5	2	3	1	2	3	5	3	5	0	1	2	3	0	1	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:116028637A>G	uc004bgv.3	+	6	716	c.530A>G	c.(529-531)GAG>GGG	p.E177G	FKBP15_uc010muu.1_Intron	NM_001859	NP_001850	O15431	COPT1_HUMAN	solute carrier family 31 (copper transporters),	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to plasma membrane	copper ion transmembrane transporter activity				0						ATGATTCAAGAGGCTCTTATG	0.333													4	5					0	0	0	0	G	116028637	G	G	116028637	3	3	219	1	0	0	0	0	1	0	0	0	14627	319	11	5		5	SLC31A1	9	116028637	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	27720960	116028637	25184794	127	40264											
AMBP	259	broad.mit.edu	37	chr9	116823771	116823771	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccgttgcccatgcagccGccgtactggaaagtctcaca	9	9	9	14	3	1	0	1	0	1	0	2	1	1	1	4	1	5	3	4	1	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:116823771G>A	uc004bie.3	-	8	1049	c.786C>T	c.(784-786)GGC>GGT	p.G262G	AMBP_uc011lxk.1_Silent_p.G203G|AMBP_uc010mvc.1_RNA	NM_001633	NP_001624	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin preproprotein	262	BPTI/Kunitz inhibitor 1.				cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			skin(1)	1					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	CCATGCAGCCGCCGTACTGGA	0.577													24	86					0	0	0	0	A	116823771	A	A	116823771	2	1	219	1	0	0	0	0	0	0	0	1	564	1074	38	1		1	AMBP	9	116823771	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	795134	116823771	24389660	128	40265											
DFNB31	25861	broad.mit.edu	37	chr9	117266938	117266938	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctccgcctcgctcagcagCgcggtcagcgcttggtgcag	4	7	14	16	6	2	0	2	0	0	0	4	0	3	0	2	2	4	5	2	2	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:117266938C>T	uc004biz.3	-	1	793	c.144G>A	c.(142-144)GCG>GCA	p.A48A	DFNB31_uc004biy.3_5'Flank|DFNB31_uc004bja.3_Silent_p.A48A|DFNB31_uc004bjb.2_Silent_p.A48A	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	48					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CGCTCAGCAGCGCGGTCAGCG	0.567													8	33					0	0	0	0	T	117266938	T	T	117266938	2	4	219	1	0	0	0	0	0	0	0	1	4477	755	27	1		1	DFNB31	9	117266938	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	443167	117266938	23946493	129	40266											
RABGAP1	23637	broad.mit.edu	37	chr9	125861042	125861042	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaaggcagaatctgagattAaaaaaaacagttctatcatt	19	10	6	6	0	3	2	1	1	2	2	3	3	3	2	0	1	1	2	0	1	7	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:125861042A>T	uc011lzh.1	+	23	2916	c.2782A>T	c.(2782-2784)AAA>TAA	p.K928*	RABGAP1_uc004bnl.3_RNA|RABGAP1_uc011lzj.1_Nonsense_Mutation_p.K267*	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	928	Potential.				cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						ATCTGAGATTAAAAAAAACAG	0.398													10	30					0	0	0	0	T	125861042	T	T	125861042	4	4	219	1	0	0	0	0	0	1	0	0	13029	363	13	5	2868	5	RABGAP1	9	125861042	Nonsense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	8594104	125861042	15352389	130	40267											
ZNF79	7633	broad.mit.edu	37	chr9	130206706	130206706	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcattcagcaccagaggattCacactggagagaagccttac	13	8	9	11	0	3	2	3	0	0	2	3	5	3	4	2	2	3	1	2	2	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:130206706C>T	uc004bqw.3	+	5	1141	c.727C>T	c.(727-729)CAC>TAC	p.H243Y	ZNF79_uc011maf.1_Missense_Mutation_p.H219Y|ZNF79_uc011mag.1_Missense_Mutation_p.H219Y	NM_007135	NP_009066	Q15937	ZNF79_HUMAN	zinc finger protein 79	243	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CCAGAGGATTCACACTGGAGA	0.537													15	59					0	0	0	0	T	130206706	T	T	130206706	3	4	219	1	0	0	0	0	1	0	0	0	18228	826	29	2	745	2	ZNF79	9	130206706	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	4345664	130206706	11006725	131	40268											
SLC27A4	10999	broad.mit.edu	37	chr9	131115719	131115719	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcctgtggtttcaatagccGcatcctgtccttcgtgtacc	5	13	10	13	2	1	0	1	0	0	0	4	0	3	0	5	2	2	3	5	2	3	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:131115719G>A	uc004but.2	+	9	1507	c.1223G>A	c.(1222-1224)CGC>CAC	p.R408H	SLC27A4_uc004buu.2_Intron	NM_005094	NP_005085	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid	408					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding				0						TTCAATAGCCGCATCCTGTCC	0.617													4	91					0	0	0	0	A	131115719	A	A	131115719	3	1	219	1	0	0	0	0	1	0	0	0	14592	1087	38	1	1253	1	SLC27A4	9	131115719	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	909013	131115719	10097712	132	40269											
RALGDS	5900	broad.mit.edu	37	chr9	135984211	135984211	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggttgacagaaatcctcCgagtactggtccagccaggt	10	8	13	10	1	0	2	0	1	0	1	3	4	3	3	4	4	2	2	4	4	2	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr9:135984211C>T	uc004cco.2	-	5	647	c.627G>A	c.(625-627)TCG>TCA	p.S209S	RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Silent_p.S197S|RALGDS_uc004ccr.2_Silent_p.S208S|RALGDS_uc011mcv.1_Silent_p.S180S|RALGDS_uc004ccs.2_Silent_p.S154S|RALGDS_uc011mcw.1_Silent_p.S280S|RALGDS_uc004ccv.1_5'UTR|RALGDS_uc004ccu.1_5'UTR	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	209	N-terminal Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		AGAAATCCTCCGAGTACTGGT	0.647			T	CIITA	PMBL|Hodgkin Lymphona|								5	33					0	0	0	0	T	135984211	T	T	135984211	2	4	219	1	0	0	0	0	0	0	0	1	13081	639	23	1		1	RALGDS	9	135984211	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	4868492	135984211	5229220	133	40270											
PFKP	5214	broad.mit.edu	37	chr10	3178029	3178029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaagaagcaaacggattttGagtaagttggctgggttccc	11	11	13	6	1	0	3	0	2	0	1	1	4	1	4	1	3	2	5	1	3	4	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr10:3178029G>C	uc001igp.2	+	21	2260	c.2224G>C	c.(2224-2226)GAG>CAG	p.E742Q	PFKP_uc001igq.2_Missense_Mutation_p.E734Q|PFKP_uc009xhr.2_Missense_Mutation_p.E704Q|PFKP_uc009xht.2_Missense_Mutation_p.E480Q|PFKP_uc009xhu.2_Missense_Mutation_p.E248Q	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	742					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		AACGGATTTTGAGTAAGTTGG	0.453													6	23					0	0	0	0	C	3178029	C	C	3178029	3	2	219	1	0	0	0	0	1	0	0	0	11821	1304	45	2	2306	2	PFKP	10	3178029	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08		3178029	132356718	134	40271											
YME1L1	10730	broad.mit.edu	37	chr10	27423860	27423860	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtatatttttggttttcatGagtttgtccaaactctcaac	9	18	7	7	0	2	1	2	1	1	0	4	1	3	1	1	2	2	3	1	2	4	7			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr10:27423860G>A	uc001iti.2	-	7	944	c.762C>T	c.(760-762)CTC>CTT	p.L254L	YME1L1_uc001itj.2_Silent_p.L197L|YME1L1_uc010qdl.1_Silent_p.L164L|YME1L1_uc009xkv.2_RNA	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	254					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						TGGTTTTCATGAGTTTGTCCA	0.393													14	37					0	0	0	0	A	27423860	A	A	27423860	2	1	219	1	0	0	0	0	0	0	0	1	17555	1277	45	2		2	YME1L1	10	27423860	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	24245831	27423860	108110887	135	40272											
NRG3	10718	broad.mit.edu	37	chr10	84745207	84745207	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattctgactgatgccagacGgtcagaagactacgaactgg	13	8	11	9	2	2	5	1	2	1	3	2	6	2	5	1	2	3	0	1	2	4	2	rs150401464	byFrequency	TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr10:84745207G>T	uc001kco.2	+	9	1964	c.1937G>T	c.(1936-1938)CGG>CTG	p.R646L	NRG3_uc010qlz.1_Missense_Mutation_p.R645L|NRG3_uc001kcp.2_Missense_Mutation_p.R449L|NRG3_uc001kcq.2_Missense_Mutation_p.R296L|NRG3_uc001kcr.2_Missense_Mutation_p.R320L	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	670	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GATGCCAGACGGTCAGAAGAC	0.483													15	29					2.32078e-09	2.5573e-09	1	0	T	84745207	T	T	84745207	3	4	219	1	0	0	0	0	1	0	0	0	10703	1116	39	3	2215	3	NRG3	10	84745207	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	57321347	84745207	50789540	136	40273											
PLCE1	51196	broad.mit.edu	37	chr10	95791019	95791019	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagcaacttgccaaagatTctctcaatagcgagggagaa	15	7	11	8	1	2	2	1	0	1	2	3	5	2	3	1	2	4	1	1	2	6	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr10:95791019T>C	uc001kjk.2	+	2	850	c.216T>C	c.(214-216)ATT>ATC	p.I72I	PLCE1_uc010qnx.1_Silent_p.I72I	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	72					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TGCCAAAGATTCTCTCAATAG	0.393													14	29					0	0	0	0	C	95791019	C	C	95791019	2	2	219	1	0	0	0	0	0	0	0	1	12089	1771	62	5		5	PLCE1	10	95791019	Silent	SNP	T	TCGA-CV-7095-01A-21D-2012-08	11045812	95791019	39743728	137	40274			1	63		4	4	813	N	T_G	6.542364e-08
PLCE1	51196	broad.mit.edu	37	chr10	95791437	95791437	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaaacttaattttagacGattgtggaaattgtgtacca	15	13	8	5	1	0	2	0	0	0	2	0	4	0	3	1	1	2	1	1	1	6	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr10:95791437G>T	uc001kjk.2	+	2	1268	c.634G>T	c.(634-636)GAT>TAT	p.D212Y	PLCE1_uc010qnx.1_Missense_Mutation_p.D212Y	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	212					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				AATTTTAGACGATTGTGGAAA	0.388													16	45					1.62849e-17	1.83537e-17	1	0	T	95791437	T	T	95791437	3	4	219	1	0	0	0	0	1	0	0	0	12089	1058	37	3	636	3	PLCE1	10	95791437	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	418	95791437	39743310	138	40275			1	63		4	4	813	N	T_G	6.542364e-08
PLCE1	51196	broad.mit.edu	37	chr10	95791784	95791784	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgatccactttgttagtcagGagattctgtaaaaatgacag	13	12	9	7	1	2	2	1	1	1	1	3	4	3	2	1	1	0	2	1	1	4	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr10:95791784G>C	uc001kjk.2	+	2	1615	c.981G>C	c.(979-981)AGG>AGC	p.R327S	PLCE1_uc010qnx.1_Missense_Mutation_p.R327S	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	327					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TGTTAGTCAGGAGATTCTGTA	0.403													13	60					0	0	0	0	C	95791784	C	C	95791784	3	2	219	1	0	0	0	0	1	0	0	0	12089	1165	41	2	983	2	PLCE1	10	95791784	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	347	95791784	39742963	139	40276			1	63		4	4	813	N	T_G	6.542364e-08
PLCE1	51196	broad.mit.edu	37	chr10	95791831	95791831	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	taagaaatctgtgtatactgGaacaagagcaattgtgagaa	17	10	10	4	0	1	3	0	1	1	3	1	5	1	4	0	1	3	2	0	1	8	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr10:95791831G>C	uc001kjk.2	+	2	1662	c.1028G>C	c.(1027-1029)GGA>GCA	p.G343A	PLCE1_uc010qnx.1_Missense_Mutation_p.G343A	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	343					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GTGTATACTGGAACAAGAGCA	0.423													9	39					0	0	0	0	C	95791831	C	C	95791831	3	2	219	1	0	0	0	0	1	0	0	0	12089	1174	41	2	1030	2	PLCE1	10	95791831	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	47	95791831	39742916	140	40277			1	63		4	4	813	N	T_G	6.542364e-08
APBB1	322	broad.mit.edu	37	chr11	6431880	6431880	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtcctctggggagccatagGaggggctgccctgggataag	7	8	17	9	0	1	0	0	0	1	0	2	3	2	3	3	6	2	1	3	6	2	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:6431880G>C	uc001mdb.1	-	2	798	c.698C>G	c.(697-699)TCC>TGC	p.S233C	APBB1_uc001mdc.1_Missense_Mutation_p.S233C|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	233					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GGAGCCATAGGAGGGGCTGCC	0.592													11	50					0	0	0	0	C	6431880	C	C	6431880	3	2	219	1	0	0	0	0	1	0	0	0	759	1174	41	2	1486	2	APBB1	11	6431880	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08		6431880	128574636	141	40278											
ST5	6764	broad.mit.edu	37	chr11	8736175	8736175	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctctcagtgatgctgtttCaatgctggacatagacaact	11	12	8	10	0	2	2	2	1	1	1	3	3	2	3	1	1	3	3	1	1	3	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:8736175C>T	uc001mgt.2	-	7	2110	c.1924G>A	c.(1924-1926)GAA>AAA	p.E642K	ST5_uc009yfr.2_Missense_Mutation_p.E222K|ST5_uc001mgu.2_Missense_Mutation_p.E222K|ST5_uc001mgv.2_Missense_Mutation_p.E642K|ST5_uc010rbq.1_RNA|ST5_uc010rbp.1_Missense_Mutation_p.E155K	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	642					positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		GATGCTGTTTCAATGCTGGAC	0.468													6	27					0	0	0	0	T	8736175	T	T	8736175	3	4	219	1	0	0	0	0	1	0	0	0	15286	835	29	2	1545	2	ST5	11	8736175	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	2304295	8736175	126270341	142	40279											
ABCC8	6833	broad.mit.edu	37	chr11	17418492	17418492	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggcgatgagggcattgaCgtgcttcagcaccggcttca	8	8	15	10	3	2	2	2	2	0	0	2	3	2	2	1	4	2	4	1	4	0	3	rs138642224	byFrequency	TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:17418492C>G	uc001mnc.2	-	33	4216	c.4090G>C	c.(4090-4092)GTC>CTC	p.V1364L		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1364	Cytoplasmic (By similarity).|ABC transporter 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGGGCATTGACGTGCTTCAGC	0.612													11	46					0	0	0	0	G	17418492	G	G	17418492	3	3	219	1	0	0	0	0	1	0	0	0	58	536	19	3	683	3	ABCC8	11	17418492	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	8682317	17418492	117588024	143	40280											
LDHC	3948	broad.mit.edu	37	chr11	18456337	18456337	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taagtggcttacctgtaactCgtgtaattggaagtggttgt	9	15	12	5	1	0	0	0	0	0	0	1	1	0	1	1	3	2	4	1	3	5	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:18456337C>T	uc001mon.3	+	5	581	c.469C>T	c.(469-471)CGT>TGT	p.R157C	LDHC_uc001mom.3_Missense_Mutation_p.R157C|LDHC_uc009yhp.2_Missense_Mutation_p.R157C|LDHC_uc001moo.3_Missense_Mutation_p.R41C|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_Missense_Mutation_p.R41C	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	157					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	ACCTGTAACTCGTGTAATTGG	0.368													40	75					0	0	0	0	T	18456337	T	T	18456337	3	4	219	1	0	0	0	0	1	0	0	0	8742	884	31	1	483	1	LDHC	11	18456337	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1037845	18456337	116550179	144	40281											
BDNF	627	broad.mit.edu	37	chr11	27679532	27679532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctatgcccctgcagccttCttttgtgtaacccatgggat	6	14	9	12	0	2	0	0	0	2	0	2	1	2	1	4	1	4	2	4	1	2	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:27679532C>T	uc010rdu.1	-	2	1431	c.580G>A	c.(580-582)GAA>AAA	p.E194K	BDNFOS_uc001mrm.2_Intron|BDNFOS_uc009yij.2_Intron|BDNFOS_uc009yik.2_Intron|BDNFOS_uc009yil.2_Intron|BDNFOS_uc001mrp.2_Intron|BDNFOS_uc009yim.2_Intron|BDNFOS_uc009yin.2_Intron|BDNFOS_uc009yio.2_Intron|BDNFOS_uc009yip.2_Intron|BDNFOS_uc001mrn.2_Intron|BDNFOS_uc009yiq.2_Intron|BDNFOS_uc001mro.2_Intron|BDNFOS_uc009yir.2_Intron|BDNFOS_uc009yis.2_Intron|BDNFOS_uc009yit.2_Intron|BDNFOS_uc009yiu.2_Intron|BDNFOS_uc009yiv.2_Intron|BDNFOS_uc009yiw.2_Intron|BDNFOS_uc009yix.2_Intron|BDNFOS_uc009yiy.2_Intron|BDNFOS_uc009yiz.2_Intron|BDNFOS_uc001mrq.3_Intron|BDNFOS_uc001mrr.3_Intron|BDNFOS_uc009yja.2_Intron|BDNFOS_uc009yjb.2_Intron|BDNF_uc010rdv.1_Missense_Mutation_p.E194K|BDNF_uc001mrt.2_Missense_Mutation_p.E209K|BDNF_uc010rdw.1_Missense_Mutation_p.E194K|BDNF_uc009yjd.2_Missense_Mutation_p.E194K|BDNF_uc001mru.2_Missense_Mutation_p.E194K|BDNF_uc010rdx.1_Missense_Mutation_p.E194K|BDNF_uc010rdy.1_Missense_Mutation_p.E194K|BDNF_uc009yjg.2_Missense_Mutation_p.E194K|BDNF_uc009yje.2_Missense_Mutation_p.E276K|BDNF_uc009yjf.2_Missense_Mutation_p.E223K|BDNF_uc001mrv.2_Missense_Mutation_p.E194K|BDNF_uc001mrw.3_Missense_Mutation_p.E194K|BDNF_uc001mrx.2_Missense_Mutation_p.E194K|BDNF_uc001mry.3_Missense_Mutation_p.E194K|BDNF_uc001mrz.3_Missense_Mutation_p.E194K|BDNF_uc001msa.2_Missense_Mutation_p.E202K	NM_001143816	NP_001137288	P23560	BDNF_HUMAN	brain-derived neurotrophic factor isoform a	194						extracellular region	growth factor activity				0						CTGCAGCCTTCTTTTGTGTAA	0.512													38	108					0	0	0	0	T	27679532	T	T	27679532	3	4	219	1	0	0	0	0	1	0	0	0	1396	922	32	2	167	2	BDNF	11	27679532	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	9223195	27679532	107326984	145	40282											
ELP4	26610	broad.mit.edu	37	chr11	31531473	31531473	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcggccctcgactggtgTccattgcgggcacgcgaccg	6	6	14	15	6	0	0	0	0	0	0	2	2	1	0	3	3	2	1	3	3	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:31531473T>C	uc001mtb.2	+	1	177	c.142T>C	c.(142-144)TCC>CCC	p.S48P	IMMP1L_uc001msy.1_5'Flank|IMMP1L_uc001msz.1_5'Flank|ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Missense_Mutation_p.S48P|ELP4_uc010rdz.1_Missense_Mutation_p.S48P|IMMP1L_uc009yjo.2_5'Flank|IMMP1L_uc009yjp.2_5'Flank	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	48					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					TCGACTGGTGTCCATTGCGGG	0.627													27	59					0	0	0	0	C	31531473	C	C	31531473	3	2	219	1	0	0	0	0	1	0	0	0	5106	1667	58	5	144	5	ELP4	11	31531473	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	3851941	31531473	103475043	146	40283											
PRR5L	79899	broad.mit.edu	37	chr11	36472865	36472865	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcggggaccgtagcttctCaggccccacgtacacgctgg	7	6	13	15	4	1	0	1	0	1	0	2	1	1	1	3	4	3	4	3	4	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:36472865C>G	uc001mwo.3	+	8	1081	c.692C>G	c.(691-693)TCA>TGA	p.S231*	PRR5L_uc001mwp.2_Nonsense_Mutation_p.S231*|PRR5L_uc009ykk.2_Nonsense_Mutation_p.S103*|PRR5L_uc010rfc.1_Intron	NM_001160167	NP_001153639	Q6MZQ0	PRR5L_HUMAN	protor-2 isoform a	231										ovary(1)	1						CGTAGCTTCTCAGGCCCCACG	0.537													13	37					0	0	0	0	G	36472865	G	G	36472865	4	3	219	1	0	0	0	0	0	1	0	0	12664	838	29	2	724	2	PRR5L	11	36472865	Nonsense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	4941392	36472865	98533651	147	40284											
MAPK8IP1	9479	broad.mit.edu	37	chr11	45926322	45926322	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aacccgccctccagctgtgtCctggagatcagcgtgcgggg	6	7	14	14	3	1	1	1	0	0	1	3	2	3	1	4	3	4	1	4	3	1	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:45926322C>G	uc001nbr.2	+	9	2000	c.1830C>G	c.(1828-1830)GTC>GTG	p.V610V		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	610	PID.				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		CCAGCTGTGTCCTGGAGATCA	0.607													28	86					0	0	0	0	G	45926322	G	G	45926322	2	3	219	1	0	0	0	0	0	0	0	1	9337	842	30	2		2	MAPK8IP1	11	45926322	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	9453457	45926322	89080194	148	40285											
FOLH1	2346	broad.mit.edu	37	chr11	49229949	49229949	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccgagtcggtttcgtgaaGgagattccacatctcggcgc	8	9	13	11	5	1	2	0	1	1	1	5	4	2	2	2	3	1	1	2	3	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:49229949G>A	uc001ngy.2	-	1	274	c.13C>T	c.(13-15)CTT>TTT	p.L5F	FOLH1_uc001ngz.2_Missense_Mutation_p.L5F|FOLH1_uc009yly.2_5'UTR|FOLH1_uc009ylz.2_5'UTR|FOLH1_uc009yma.2_5'UTR|FOLH1_uc001nha.2_5'UTR	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	5	Cytoplasmic (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GTTTCGTGAAGGAGATTCCAC	0.701													3	9					0	0	0	0	A	49229949	A	A	49229949	3	1	219	1	0	0	0	0	1	0	0	0	6011	1000	35	4	2315	4	FOLH1	11	49229949	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	3303627	49229949	85776567	149	40286											
TCN1	6947	broad.mit.edu	37	chr11	59631479	59631479	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggacaacacaacattgacagCgctggttcccctgttatagt	11	10	9	11	1	0	1	0	1	0	0	1	2	1	2	2	2	3	3	2	2	4	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:59631479C>T	uc001noj.2	-	2	258	c.160G>A	c.(160-162)GCT>ACT	p.A54T		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	54					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACATTGACAGCGCTGGTTCCC	0.418													45	150					0	0	0	0	T	59631479	T	T	59631479	3	4	219	1	0	0	0	0	1	0	0	0	15772	768	27	1	1173	1	TCN1	11	59631479	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	10401530	59631479	75375037	150	40287											
CPSF7	79869	broad.mit.edu	37	chr11	61188974	61188974	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagatggctcctggcgaacaGgaggaggtggttcagtgctg	8	8	18	7	1	1	1	1	0	0	1	2	5	2	3	1	6	2	3	1	6	1	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:61188974G>C	uc001nrq.2	-	3	295	c.161C>G	c.(160-162)CCT>CGT	p.P54R	CPSF7_uc001nro.2_Missense_Mutation_p.P54R|CPSF7_uc001nrp.2_Missense_Mutation_p.P97R|CPSF7_uc001nrr.2_Missense_Mutation_p.P54R|CPSF7_uc001nrs.1_5'UTR|CPSF7_uc009ynp.2_Missense_Mutation_p.P54R	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	54	Poly-Pro.				mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						CTGGCGAACAGGAGGAGGTGG	0.522													19	79					0	0	0	0	C	61188974	C	C	61188974	3	2	219	1	0	0	0	0	1	0	0	0	3845	1000	35	4	1282	4	CPSF7	11	61188974	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1557495	61188974	73817542	151	40288											
VEGFB	7423	broad.mit.edu	37	chr11	64005048	64005048	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagcgccctgacccccggAcctgccgctgccgctgccga	5	4	11	21	5	0	1	0	1	0	0	0	3	0	2	8	1	4	2	8	1	0	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:64005048A>C	uc001nyw.2	+	6	607	c.567A>C	c.(565-567)GGA>GGC	p.G189G	VEGFB_uc001nyx.2_Missense_Mutation_p.T156P	NM_003377	NP_003368	P49765	VEGFB_HUMAN	vascular endothelial growth factor B precursor	189					anti-apoptosis|induction of positive chemotaxis|negative regulation of gene expression|negative regulation of neuron apoptosis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular wound healing|vascular endothelial growth factor receptor signaling pathway	extracellular region|extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|heparin binding|vascular endothelial growth factor receptor 1 binding				0						TGACCCCCGGACCTGCCGCTG	0.711													5	6					0	0	0	0	C	64005048	C	C	64005048	2	2	219	1	0	0	0	0	0	0	0	1	17219	262	10	5		5	VEGFB	11	64005048	Silent	SNP	A	TCGA-CV-7095-01A-21D-2012-08	2816074	64005048	71001468	152	40289											
PYGM	5837	broad.mit.edu	37	chr11	64525340	64525340	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaactcgggccgggccttctCccaggggttgccgtagcgaa	6	7	15	13	4	1	0	0	0	1	0	3	2	1	0	4	4	3	2	4	4	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:64525340C>G	uc001oax.3	-	5	1388	c.571G>C	c.(571-573)GAG>CAG	p.E191Q	PYGM_uc001oay.3_Missense_Mutation_p.E103Q	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	191					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CGGGCCTTCTCCCAGGGGTTG	0.607													18	25					0	0	0	0	G	64525340	G	G	64525340	3	3	219	1	0	0	0	0	1	0	0	0	12927	864	30	2	2021	2	PYGM	11	64525340	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	520292	64525340	70481176	153	40290											
SPTBN2	6712	broad.mit.edu	37	chr11	66488701	66488701	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagtctgtgggtgacagcGtgctgctcatggtggtaggc	7	10	16	8	1	2	1	1	1	1	0	2	1	2	1	0	4	3	3	0	4	2	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:66488701G>A	uc001ojd.2	-	2	83	c.11C>T	c.(10-12)ACG>ATG	p.T4M		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	4	Actin-binding.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GGGTGACAGCGTGCTGCTCAT	0.602													20	125					0	0	0	0	A	66488701	A	A	66488701	3	1	219	1	0	0	0	0	1	0	0	0	15186	1145	40	1	7305	1	SPTBN2	11	66488701	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1963361	66488701	68517815	154	40291											
SSH3	54961	broad.mit.edu	37	chr11	67077772	67077772	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtcttctggagccctccttgGagctggagagcacctcagag	7	9	13	12	0	3	2	1	0	2	2	4	5	4	4	3	3	3	2	3	3	0	2	rs148598265		TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:67077772G>T	uc001okj.2	+	13	1823	c.1645G>T	c.(1645-1647)GAG>TAG	p.E549*	SSH3_uc001okk.2_RNA|SSH3_uc001okl.2_Nonsense_Mutation_p.E403*	NM_017857	NP_060327	Q8TE77	SSH3_HUMAN	slingshot homolog 3	549					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCCCTCCTTGGAGCTGGAGAG	0.632													13	188					4.3838e-07	4.7698e-07	1	0	T	67077772	T	T	67077772	4	4	219	1	0	0	0	0	0	1	0	0	15252	1175	41	2	1695	2	SSH3	11	67077772	Nonsense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	589071	67077772	67928744	155	40292											
PITPNM1	9600	broad.mit.edu	37	chr11	67267280	67267280	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatctccttggggaagaccTcctcactgtccgagaagcct	8	10	9	14	1	3	2	2	0	1	2	6	4	5	3	5	2	1	0	5	2	2	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:67267280T>C	uc001olx.2	-	7	1274	c.1085A>G	c.(1084-1086)GAG>GGG	p.E362G	PITPNM1_uc001olw.2_5'Flank|PITPNM1_uc001oly.2_Missense_Mutation_p.E362G|PITPNM1_uc001olz.2_Missense_Mutation_p.E362G	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	362					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						GGGGAAGACCTCCTCACTGTC	0.592													10	121					0	0	0	0	C	67267280	C	C	67267280	3	2	219	1	0	0	0	0	1	0	0	0	12005	1551	54	5	2717	5	PITPNM1	11	67267280	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	189508	67267280	67739236	156	40293											
TCIRG1	10312	broad.mit.edu	37	chr11	67816564	67816564	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcactttggccagaggCaccggctgctgctggagacg	7	6	15	13	2	0	2	0	0	0	2	0	3	0	2	3	5	2	5	3	5	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:67816564C>T	uc001one.2	+	15	1798	c.1690C>T	c.(1690-1692)CAC>TAC	p.H564Y	TCIRG1_uc001ong.2_Missense_Mutation_p.H348Y|TCIRG1_uc001onh.2_Missense_Mutation_p.H266Y|TCIRG1_uc001oni.2_Missense_Mutation_p.H68Y|TCIRG1_uc009ysd.2_5'Flank	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	564	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						TGGCCAGAGGCACCGGCTGCT	0.657													23	238					0	0	0	0	T	67816564	T	T	67816564	3	4	219	1	0	0	0	0	1	0	0	0	15769	710	25	4	1744	4	TCIRG1	11	67816564	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	549284	67816564	67189952	157	40294											
NCAPD3	23310	broad.mit.edu	37	chr11	134072795	134072795	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgtctgcctttggtaggAaaaagctttaaaaaaaaaat	18	11	8	4	0	1	1	0	0	1	1	1	2	1	2	1	2	2	2	1	2	8	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr11:134072795A>G	uc001qhd.1	-	13	2137	c.1531T>C	c.(1531-1533)TCC>CCC	p.S511P	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	511					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CTTTGGTAGGAAAAAGCTTTA	0.348													16	16					0	0	0	0	G	134072795	G	G	134072795	3	3	219	1	0	0	0	0	1	0	0	0	10260	246	9	5	3057	5	NCAPD3	11	134072795	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	66256231	134072795	933721	158	40295											
GDF3	9573	broad.mit.edu	37	chr12	7842822	7842822	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gggacagggatggctgctctCcttttccgagaagggtggca	7	9	16	9	1	1	1	0	0	1	1	3	4	2	3	2	5	1	3	2	5	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:7842822C>G	uc001qte.2	-	2	783	c.747G>C	c.(745-747)AGG>AGC	p.R249S		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	249					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						TGGCTGCTCTCCTTTTCCGAG	0.537													20	59					0	0	0	0	G	7842822	G	G	7842822	3	3	219	1	0	0	0	0	1	0	0	0	6352	854	30	2	351	2	GDF3	12	7842822	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08		7842822	126009073	159	40296											
SLC2A14	144195	broad.mit.edu	37	chr12	7980270	7980270	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcctgggtgccccacaaccGctggaggactggtgaaaaga	11	6	13	11	1	0	2	0	1	0	1	1	4	1	4	4	4	2	1	4	4	3	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:7980270G>A	uc001qtk.2	-	12	1547	c.754C>T	c.(754-756)CGG>TGG	p.R252W	SLC2A14_uc001qtl.2_Missense_Mutation_p.R229W|SLC2A14_uc001qtm.2_Missense_Mutation_p.R229W|SLC2A14_uc010sgg.1_Missense_Mutation_p.R143W|SLC2A14_uc001qtn.2_Missense_Mutation_p.R252W|SLC2A14_uc001qto.2_Intron|SLC2A14_uc010sgh.1_Missense_Mutation_p.R267W	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	252	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		CCCCACAACCGCTGGAGGACT	0.507													7	46					0	0	0	0	A	7980270	A	A	7980270	3	1	219	1	0	0	0	0	1	0	0	0	14607	1086	38	1	828	1	SLC2A14	12	7980270	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	137448	7980270	125871625	160	40297											
SLC2A3	6515	broad.mit.edu	37	chr12	8082459	8082459	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcctgggtgccccacaaccGctggaggactggtgaaaaga	11	6	13	11	1	0	2	0	1	0	1	1	4	1	4	4	4	2	1	4	4	3	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:8082459G>A	uc001qtr.2	-	6	944	c.682C>T	c.(682-684)CGG>TGG	p.R228W	SLC2A3_uc001qts.2_3'UTR	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	228	Cytoplasmic (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		CCCCACAACCGCTGGAGGACT	0.498													12	89					0	0	0	0	A	8082459	A	A	8082459	3	1	219	1	0	0	0	0	1	0	0	0	14609	1086	38	1	828	1	SLC2A3	12	8082459	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	102189	8082459	125769436	161	40298											
TAS2R20	259295	broad.mit.edu	37	chr12	11150362	11150362	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctgaggagatcttttgtCtcttgacccaggcaatgaaa	11	11	10	9	0	2	4	0	3	2	1	3	5	2	4	1	2	1	2	1	2	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:11150362C>T	uc001qzm.2	-	1	113	c.113G>A	c.(112-114)AGA>AAA	p.R38K	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176889	NP_795370	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	38	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						GATCTTTTGTCTCTTGACCCA	0.378													23	46					0	0	0	0	T	11150362	T	T	11150362	3	4	219	1	0	0	0	0	1	0	0	0	15637	913	32	2	820	2	TAS2R20	12	11150362	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	3067903	11150362	122701533	162	40299											
TAS2R31	259290	broad.mit.edu	37	chr12	11183044	11183044	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcctttcacccagtacctCacttgccgcaaaactgaaag	11	10	5	15	1	3	1	2	1	1	0	4	1	3	1	4	0	3	2	4	0	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:11183044C>G	uc001qzo.1	-	1	963	c.891G>C	c.(889-891)GTG>GTC	p.V297V	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	297	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						CCCAGTACCTCACTTGCCGCA	0.428													48	182					0	0	0	0	G	11183044	G	G	11183044	2	3	219	1	0	0	0	0	0	0	0	1	15640	813	29	2		2	TAS2R31	12	11183044	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	32682	11183044	122668851	163	40300											
PLCZ1	89869	broad.mit.edu	37	chr12	18889205	18889205	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaccgaatatctaatttttCaagtaacctctgagtttttt	11	17	5	8	1	3	1	1	1	2	0	3	2	3	1	2	0	1	3	2	0	5	8			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:18889205C>G	uc010sid.1	-	3	276	c.85G>C	c.(85-87)GAA>CAA	p.E29Q	PLCZ1_uc001rdv.3_5'UTR|PLCZ1_uc001rdw.3_5'UTR|CAPZA3_uc001rdy.2_5'Flank	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	29					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					TCTAATTTTTCAAGTAACCTC	0.353													8	26					0	0	0	0	G	18889205	G	G	18889205	3	3	219	1	0	0	0	0	1	0	0	0	12099	835	29	2	1793	2	PLCZ1	12	18889205	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	7706161	18889205	114962690	164	40301											
SENP1	29843	broad.mit.edu	37	chr12	48477537	48477537	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actttcccgcaaaactgtttGataatccactaaaaaaagag	17	10	5	9	1	0	2	0	1	0	1	2	2	2	2	2	0	1	2	2	0	7	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:48477537G>C	uc001rqx.2	-	6	835	c.389C>G	c.(388-390)TCA>TGA	p.S130*	SENP1_uc001rqw.2_Nonsense_Mutation_p.S130*|SENP1_uc001rqy.2_Translation_Start_Site|SENP1_uc001rqz.2_Translation_Start_Site|SENP1_uc009zkx.2_Nonsense_Mutation_p.S130*	NM_014554	NP_055369	Q9P0U3	SENP1_HUMAN	sentrin/SUMO-specific protease 1	130	Ser-rich.				activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			pancreas(2)|lung(1)	3		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				AAAACTGTTTGATAATCCACT	0.313													10	37					0	0	0	0	C	48477537	C	C	48477537	4	2	219	1	0	0	0	0	0	1	0	0	14111	1294	45	2	1594	2	SENP1	12	48477537	Nonsense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	29588332	48477537	85374358	165	40302											
PPP1R1A	5502	broad.mit.edu	37	chr12	54975892	54975892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctgctgttgccccaggtGatgttcaaccatcatctgga	7	13	10	11	0	3	1	2	1	1	0	3	2	3	2	3	2	4	4	3	2	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:54975892G>A	uc001sgg.2	-	5	442	c.271C>T	c.(271-273)CAC>TAC	p.H91Y		NM_006741	NP_006732	Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	91					glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity				0						TGCCCCAGGTGATGTTCAACC	0.592													12	27					0	0	0	0	A	54975892	A	A	54975892	3	1	219	1	0	0	0	0	1	0	0	0	12427	1290	45	2	256	2	PPP1R1A	12	54975892	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	6498355	54975892	78876003	166	40303											
LRP1	4035	broad.mit.edu	37	chr12	57538855	57538855	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaggatacctcctgcagccGgataaccgctcctgcaaggc	10	6	11	14	2	0	0	0	0	0	0	2	3	2	2	5	3	5	3	5	3	4	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:57538855G>A	uc001snd.2	+	5	1015	c.549G>A	c.(547-549)CCG>CCA	p.P183P	LRP1_uc010sre.1_Silent_p.P183P|LRP1_uc001snb.2_Silent_p.P183P|LRP1_uc001snc.1_Silent_p.P183P	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	183	EGF-like 2; calcium-binding (Potential).|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TCCTGCAGCCGGATAACCGCT	0.572													17	31					0	0	0	0	A	57538855	A	A	57538855	2	1	219	1	0	0	0	0	0	0	0	1	9001	1103	39	1		1	LRP1	12	57538855	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	2562963	57538855	76313040	167	40304											
CDK4	1019	broad.mit.edu	37	chr12	58145367	58145369	+	In_Frame_Del	DEL	CCT	-	-																															tgatgggaaggcctcctccaCctcctcctccattggggact																										TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:58145367_58145369delCCT	uc001spv.2	-	2	359_361	c.132_134delAGG	c.(130-135)GGAGGT>GGT	p.44_45GG>G	CDK4_uc010ssb.1_5'UTR|CDK4_uc001spw.2_RNA|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	44_45	Poly-Gly.|Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			GCCTCCTCCACCTCCTCCTCCAT	0.567			Mis			melanoma 			Hereditary_Melanoma				---	---	---								-	58145369	-	-	58145367	7	5	219	1	0	1	0	1	0	0	0	0	3156	507	18	0	805	0	CDK4	12	58145367	In_Frame_Del	DEL	CCT	TCGA-CV-7095-01A-21D-2012-08	606512	58145367	75706528	168	40305											
GRIP1	23426	broad.mit.edu	37	chr12	66990676	66990676	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctccatcaggcggctttgtCtggctggcggatttagtgta	5	13	14	9	2	2	0	1	0	1	0	3	1	3	1	1	5	0	4	1	5	2	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:66990676C>T	uc001stk.2	-	2	328	c.87G>A	c.(85-87)CAG>CAA	p.Q29Q	GRIP1_uc010sta.1_Intron|GRIP1_uc001stm.2_Silent_p.Q29Q	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	29					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		GCGGCTTTGTCTGGCTGGCGG	0.448													19	62					0	0	0	0	T	66990676	T	T	66990676	2	4	219	1	0	0	0	0	0	0	0	1	6826	912	32	2		2	GRIP1	12	66990676	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	8845309	66990676	66861219	169	40306											
TMCC3	57458	broad.mit.edu	37	chr12	94975422	94975422	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctttcctcttgcagggtcTgagaaataaaaccatattct	12	14	6	9	0	4	1	0	1	4	1	5	2	5	1	2	1	2	1	2	1	4	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:94975422T>A	uc001tdj.2	-	2	1089	c.971A>T	c.(970-972)CAG>CTG	p.Q324L	TMCC3_uc001tdi.2_Missense_Mutation_p.Q293L	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	324	Potential.					integral to membrane				ovary(1)|skin(1)	2						TTGCAGGGTCTGAGAAATAAA	0.348													15	50					0	0	0	0	A	94975422	A	A	94975422	3	1	219	1	0	0	0	0	1	0	0	0	16060	1580	55	5	474	5	TMCC3	12	94975422	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08	27984746	94975422	38876473	170	40307											
ANO4	121601	broad.mit.edu	37	chr12	101504254	101504254	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acttctggccttactgaataAcataattgaaattcgacttg	13	14	6	8	1	1	2	0	2	1	0	2	3	1	2	1	1	2	0	1	1	5	7			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	4ed92ac0-e019-4e73-aa69-dacbfc8d2ee1	g.chr12:101504254A>G	uc010svm.1	+	23	2794	c.2222A>G	c.(2221-2223)AAC>AGC	p.N741S	ANO4_uc001thw.2_Missense_Mutation_p.N706S|ANO4_uc001thx.2_Missense_Mutation_p.N741S|ANO4_uc001thy.2_Missense_Mutation_p.N261S	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	741	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTACTGAATAACATAATTGAA	0.398										HNSCC(74;0.22)			3	73					0	0	0	0	G	101504254	G	G	101504254	3	3	219	1	0	0	0	0	1	0	0	0	699	43	2	5	2199	5	ANO4	12	101504254	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	6528832	101504254	32347641	171	40308											
ACACB	32	broad.mit.edu	37	chr12	109673414	109673414	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggatttctttttgcagaaaGaatttcccaagtttttcaca	11	17	6	7	0	2	2	1	0	1	2	3	3	3	3	1	1	1	2	1	1	3	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:109673414G>C	uc001tob.2	+	33	4527	c.4408G>C	c.(4408-4410)GAA>CAA	p.E1470Q	ACACB_uc001toc.2_Missense_Mutation_p.E1470Q|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.E136Q	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1470					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TTTGCAGAAAGAATTTCCCAA	0.328													12	20					0	0	0	0	C	109673414	C	C	109673414	3	2	219	1	0	0	0	0	1	0	0	0	107	943	33	2	4534	2	ACACB	12	109673414	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	8169160	109673414	24178481	172	40309											
DTX1	1840	broad.mit.edu	37	chr12	113496163	113496163	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaacgtgctgaaggaggacGctcgcggttccgtggtcctg	7	8	16	10	5	0	2	0	1	0	1	3	4	2	4	2	4	2	3	2	4	2	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:113496163G>A	uc001tuk.1	+	1	502	c.166G>A	c.(166-168)GCT>ACT	p.A56T		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	56	WWE 1.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						GAAGGAGGACGCTCGCGGTTC	0.647													35	89					0	0	0	0	A	113496163	A	A	113496163	3	1	219	1	0	0	0	0	1	0	0	0	4815	1087	38	1	168	1	DTX1	12	113496163	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	3822749	113496163	20355732	173	40310											
MAP1LC3B2	643246	broad.mit.edu	37	chr12	117013807	117013807	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaacaaagagtagaagatgtCcgacttattcgagagcagca	16	7	11	7	2	0	4	0	0	0	4	2	7	1	4	1	0	3	3	1	0	5	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:117013807C>G	uc009zwk.1	+	2	214	c.60C>G	c.(58-60)GTC>GTG	p.V20V		NM_001085481	NP_001078950	A6NCE7	MP3B2_HUMAN	microtubule-associated protein 1 light chain 3	20					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule					0						TAGAAGATGTCCGACTTATTC	0.537													17	96					0	0	0	0	G	117013807	G	G	117013807	2	3	219	1	0	0	0	0	0	0	0	1	9285	842	30	2		2	MAP1LC3B2	12	117013807	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	3517644	117013807	16838088	174	40311											
DNAH10	196385	broad.mit.edu	37	chr12	124333280	124333280	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtctttcttcctaggccGtggggaagattttctctggc	5	15	11	10	1	3	1	0	0	3	1	5	2	4	2	2	4	0	0	2	4	2	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr12:124333280G>A	uc001uft.3	+	33	5624	c.5599G>A	c.(5599-5601)GTG>ATG	p.V1867M		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1867	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTCCTAGGCCGTGGGGAAGAT	0.443													4	25					0	0	0	0	A	124333280	A	A	124333280	3	1	219	1	0	0	0	0	1	0	0	0	4620	1145	40	1	5729	1	DNAH10	12	124333280	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	7319473	124333280	9518615	175	40312											
SACS	26278	broad.mit.edu	37	chr13	23913048	23913048	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtactactaacttcactcActtttgcttcctgttgagtt	8	17	5	11	1	2	1	2	1	0	0	3	1	3	1	1	0	4	4	1	0	3	9			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr13:23913048A>C	uc001uon.2	-	10	5556	c.4967T>G	c.(4966-4968)GTG>GGG	p.V1656G	SACS_uc001uoo.2_Missense_Mutation_p.V1509G|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1656					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AACTTCACTCACTTTTGCTTC	0.398													16	41					0	0	0	0	C	23913048	C	C	23913048	3	2	219	1	0	0	0	0	1	0	0	0	13869	159	6	5	8776	5	SACS	13	23913048	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08		23913048	91256830	176	40313											
KL	9365	broad.mit.edu	37	chr13	33590903	33590903	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagactcccggaacgccagtCtgccgttgggcgccccgtcg	5	6	14	16	6	1	1	0	0	1	1	3	3	2	2	5	2	2	1	5	2	1	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr13:33590903C>G	uc001uus.2	+	1	333	c.325C>G	c.(325-327)CTG>GTG	p.L109V	KL_uc001uur.1_Intron	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	109	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GAACGCCAGTCTGCCGTTGGG	0.711													4	23					0	0	0	0	G	33590903	G	G	33590903	3	3	219	1	0	0	0	0	1	0	0	0	8370	912	32	2	327	2	KL	13	33590903	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	9677855	33590903	81578975	177	40314											
FARP1	10160	broad.mit.edu	37	chr13	99092944	99092944	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcccctgatgaagccaccGcggctgaccaggagtcagag	10	5	13	13	2	1	4	1	3	0	1	2	5	2	5	5	2	1	1	5	2	1	0	rs145597966	byFrequency	TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr13:99092944G>A	uc001vnj.2	+	24	2986	c.2650G>A	c.(2650-2652)GCG>ACG	p.A884T	FARP1_uc001vnh.2_Missense_Mutation_p.A915T	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	884					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TGAAGCCACCGCGGCTGACCA	0.627													7	64					0	0	0	0	A	99092944	A	A	99092944	3	1	219	1	0	0	0	0	1	0	0	0	5708	1087	38	1	2963	1	FARP1	13	99092944	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	65502041	99092944	16076934	178	40315											
C13orf39	196541	broad.mit.edu	37	chr13	103338495	103338495	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaattcatagtcggtgctGaacctgaatttgtttgccca	12	13	8	8	1	1	2	1	2	0	0	2	2	1	2	2	1	3	2	2	1	5	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr13:103338495G>A	uc001vpj.2	-	4	687	c.681C>T	c.(679-681)TTC>TTT	p.F227F	C13orf39_uc001vpk.2_Silent_p.F227F	NM_001010977	NP_001010977	Q5VZV1	MT21C_HUMAN	hypothetical protein LOC196541	227							methyltransferase activity				0						AGTCGGTGCTGAACCTGAATT	0.443													12	42					0	0	0	0	A	103338495	A	A	103338495	2	1	219	1	0	0	0	0	0	0	0	1	1738	1281	45	2		2	C13orf39	13	103338495	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	4245551	103338495	11831383	179	40316											
MYH7	4625	broad.mit.edu	37	chr14	23887505	23887505	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acctccgagttggccttggaAaggacgcgctgcagctcggc	7	7	14	13	4	0	0	0	0	0	0	2	3	1	2	3	4	2	4	3	4	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	4ed92ac0-e019-4e73-aa69-dacbfc8d2ee1	g.chr14:23887505A>C	uc001wjx.2	-	30	4189	c.4083T>G	c.(4081-4083)CTT>CTG	p.L1361L	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1361	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGGCCTTGGAAAGGACGCGCT	0.652													5	100					0	0	0	0	C	23887505	C	C	23887505	2	2	219	1	0	0	0	0	0	0	0	1	10092	1	1	5		5	MYH7	14	23887505	Silent	SNP	A	TCGA-CV-7095-01A-21D-2012-08		23887505	83462035	180	40317											
COCH	1690	broad.mit.edu	37	chr14	31348691	31348691	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacagcacatccaccaacaGgtatgaactatgaaacctat	16	7	5	13	0	0	2	0	2	0	0	1	2	1	2	4	1	4	2	4	1	6	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr14:31348691G>C	uc001wqr.2	+	6	516	c.436G>C	c.(436-438)GGT>CGT	p.G146R	COCH_uc001wqp.2_Missense_Mutation_p.G146R|COCH_uc001wqq.3_Missense_Mutation_p.G146R|uc001wqs.2_Intron|COCH_uc001wqt.1_5'Flank	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	146					sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TCCACCAACAGGTATGAACTA	0.383													9	58					0	0	0	0	C	31348691	C	C	31348691	3	2	219	1	0	0	0	0	1	0	0	0	3671	1014	35	4	454	4	COCH	14	31348691	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	7461186	31348691	76000849	181	40318											
NIN	51199	broad.mit.edu	37	chr14	51224285	51224285	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcgtccctgtacttcccaGgtcccggacctcatcatctt	5	12	7	17	2	3	0	2	0	1	0	7	1	6	1	4	2	1	2	4	2	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr14:51224285G>A	uc001wym.2	-	18	3654	c.3463C>T	c.(3463-3465)CTG>TTG	p.L1155L	NIN_uc001wyi.2_Silent_p.L1155L|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Silent_p.L1161L|NIN_uc001wyo.2_Silent_p.L1155L	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1155					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GTACTTCCCAGGTCCCGGACC	0.478			T	PDGFRB	MPD								23	208					0	0	0	0	A	51224285	A	A	51224285	2	1	219	1	0	0	0	0	0	0	0	1	10471	991	35	4		4	NIN	14	51224285	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	19875594	51224285	56125255	182	40319											
SIX6	4990	broad.mit.edu	37	chr14	60976681	60976681	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaccgagcggctgcagccAagaacaggtcggtacctaga	11	4	15	11	3	0	2	0	0	0	2	1	4	0	3	3	4	5	3	3	4	4	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr14:60976681A>T	uc001xfa.3	+	1	744	c.565A>T	c.(565-567)AAG>TAG	p.K189*		NM_007374	NP_031400	O95475	SIX6_HUMAN	SIX homeobox 6	189					organ morphogenesis|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.088)		GGCTGCAGCCAAGAACAGGTC	0.647													6	12					0	0	0	0	T	60976681	T	T	60976681	4	4	219	1	0	0	0	0	0	1	0	0	14416	131	5	5	567	5	SIX6	14	60976681	Nonsense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	9752396	60976681	46372859	183	40320											
SIPA1L1	26037	broad.mit.edu	37	chr14	72055505	72055505	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcgcaatgccaaaggtgaaGaacttgggaagtcatcagat	14	8	12	7	1	2	3	2	1	0	2	2	4	2	4	1	2	3	1	1	2	5	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr14:72055505G>C	uc001xms.2	+	2	1264	c.916G>C	c.(916-918)GAA>CAA	p.E306Q	SIPA1L1_uc001xmt.2_Missense_Mutation_p.E306Q|SIPA1L1_uc001xmu.2_Missense_Mutation_p.E306Q|SIPA1L1_uc001xmv.2_Missense_Mutation_p.E306Q	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	306					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CAAAGGTGAAGAACTTGGGAA	0.433													13	47					0	0	0	0	C	72055505	C	C	72055505	3	2	219	1	0	0	0	0	1	0	0	0	14394	943	33	2	918	2	SIPA1L1	14	72055505	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	11078824	72055505	35294035	184	40321											
TRIP11	9321	broad.mit.edu	37	chr14	92461767	92461767	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgctttacttgttcctgaGagacagaaagctgcagcgca	11	10	10	10	1	0	3	0	1	0	2	1	4	1	3	1	0	5	5	1	0	2	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr14:92461767G>A	uc001xzy.2	-	14	5773	c.4985C>T	c.(4984-4986)TCT>TTT	p.S1662F	TRIP11_uc010auf.1_Missense_Mutation_p.S1398F	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1662	Potential.			QLSVSQEQ -> RFCLSGT (in Ref. 1; AAD09135).	transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTGTTCCTGAGAGACAGAAAG	0.458			T	PDGFRB	AML								24	23					0	0	0	0	A	92461767	A	A	92461767	3	1	219	1	0	0	0	0	1	0	0	0	16622	942	33	2	986	2	TRIP11	14	92461767	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	20406262	92461767	14887773	185	40322											
DLK1	8788	broad.mit.edu	37	chr14	101201194	101201194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccccgagaagatcgacatGaccaccttcagcaaggaggc	12	6	10	13	2	1	3	1	1	0	2	3	6	2	4	4	2	1	1	4	2	2	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr14:101201194G>A	uc001yhs.3	+	5	1266	c.1113G>A	c.(1111-1113)ATG>ATA	p.M371I	DLK1_uc001yhu.3_Missense_Mutation_p.M298I	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	371	Cytoplasmic (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				AGATCGACATGACCACCTTCA	0.562													35	97					0	0	0	0	A	101201194	A	A	101201194	3	1	219	1	0	0	0	0	1	0	0	0	4586	1290	45	2	1131	2	DLK1	14	101201194	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	8739427	101201194	6148346	186	40323											
NDN	4692	broad.mit.edu	37	chr15	23932088	23932088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caccagctgcgccggggctgGcggtgccgggcccggctggg	2	4	20	15	5	0	0	0	0	0	0	0	0	0	0	4	7	3	3	4	7	0	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:23932088G>A	uc001ywk.2	-	1	363	c.277C>T	c.(277-279)CCA>TCA	p.P93S		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	93					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		GCCGGGGCTGGCGGTGCCGGG	0.697									Prader-Willi_syndrome				8	31					0	0	0	0	A	23932088	A	A	23932088	3	1	219	1	0	0	0	0	1	0	0	0	10301	1203	42	4	692	4	NDN	15	23932088	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08		23932088	78599304	187	40324											
C15orf55	256646	broad.mit.edu	37	chr15	34649168	34649168	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcaggagtcttacacaactGggactcccaaagcaacatct	13	8	8	12	0	3	0	1	0	2	0	4	2	4	2	1	2	4	1	1	2	4	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:34649168G>T	uc001zif.2	+	7	3030	c.2875G>T	c.(2875-2877)GGG>TGG	p.G959W	C15orf55_uc010ucc.1_Missense_Mutation_p.G987W|C15orf55_uc010ucd.1_Missense_Mutation_p.G977W	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	959						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		TTACACAACTGGGACTCCCAA	0.483			T	BRD3|BRD4	lethal midline carcinoma								15	26					4.93089e-13	5.48581e-13	1	0	T	34649168	T	T	34649168	3	4	219	1	0	0	0	0	1	0	0	0	1809	1348	47	4	2901	4	C15orf55	15	34649168	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	10717080	34649168	67882224	188	40325											
MAP1A	4130	broad.mit.edu	37	chr15	43820775	43820775	+	Frame_Shift_Del	DEL	C	-	-																															ccaactgaaaccagccctaaCcccccaggccctgccccagc																										TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:43820775delC	uc001zrt.2	+	4	7571	c.7104delC	c.(7102-7104)AACfs	p.N2368fs		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2368						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCAGCCCTAACCCCCCAGGCC	0.642													---	---	---								-	43820775	-	-	43820775	7	5	219	1	0	1	0	1	0	0	0	0	9280	506	18	0	7106	0	MAP1A	15	43820775	Frame_Shift_Del	DEL	C	TCGA-CV-7095-01A-21D-2012-08	9171607	43820775	58710617	189	40326											
USP8	9101	broad.mit.edu	37	chr15	50774167	50774167	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgccaagaaatctgtagaaGatagggggaaaaggtgtcca	16	7	13	5	0	1	3	0	0	1	3	2	4	2	4	2	3	1	1	2	3	7	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:50774167G>C	uc001zym.3	+	12	2208	c.1708G>C	c.(1708-1710)GAT>CAT	p.D570H	USP8_uc001zyk.1_Missense_Mutation_p.D271H|USP8_uc001zyl.3_Missense_Mutation_p.D570H|USP8_uc001zyn.3_Missense_Mutation_p.D570H|USP8_uc010ufh.1_Missense_Mutation_p.D493H|USP8_uc010bev.1_Missense_Mutation_p.D199H	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	570					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		ATCTGTAGAAGATAGGGGGAA	0.313													10	29					0	0	0	0	C	50774167	C	C	50774167	3	2	219	1	0	0	0	0	1	0	0	0	17157	942	33	2	1746	2	USP8	15	50774167	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	6953392	50774167	51757225	190	40327											
USP8	9101	broad.mit.edu	37	chr15	50791262	50791262	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttatacttcattgggaccaCgagtaactgatgtagccaca	12	12	8	9	1	1	1	1	1	0	0	1	3	1	2	2	1	3	2	2	1	4	7	rs142928952		TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:50791262C>T	uc001zym.3	+	21	3834	c.3334C>T	c.(3334-3336)CGA>TGA	p.R1112*	USP8_uc001zyl.3_Nonsense_Mutation_p.R1112*|USP8_uc001zyn.3_Nonsense_Mutation_p.R1112*|USP8_uc010ufh.1_Nonsense_Mutation_p.R1006*|USP8_uc001zyp.3_Nonsense_Mutation_p.R279*	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	1112					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		ATTGGGACCACGAGTAACTGA	0.368													12	33					0	0	0	0	T	50791262	T	T	50791262	4	4	219	1	0	0	0	0	0	1	0	0	17157	528	19	1	3408	1	USP8	15	50791262	Nonsense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	17095	50791262	51740130	191	40328											
UNC13C	440279	broad.mit.edu	37	chr15	54916087	54916087	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaaccttggagacaagaaGagaaaacaaggcacaaaaac	21	2	8	10	0	0	3	0	0	0	3	0	5	0	3	2	2	3	1	2	2	8	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:54916087G>T	uc002ack.2	+	30	6294	c.6294G>T	c.(6292-6294)AAG>AAT	p.K2098N	UNC13C_uc002acm.2_Missense_Mutation_p.K19N	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	2098	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GAGACAAGAAGAGAAAACAAG	0.403													19	45					8.28177e-16	9.30355e-16	1	0	T	54916087	T	T	54916087	3	4	219	1	0	0	0	0	1	0	0	0	17054	933	33	2	6412	2	UNC13C	15	54916087	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	4124825	54916087	47615305	192	40329											
NEDD4	4734	broad.mit.edu	37	chr15	56207863	56207863	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccatttgttgtttcacaGtctaatgtagctgcttttcg	7	18	7	9	1	3	0	2	0	1	0	4	0	3	0	1	0	2	5	1	0	2	7			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:56207863G>A	uc002adj.2	-	1	1467	c.1167C>T	c.(1165-1167)GAC>GAT	p.D389D	NEDD4_uc002adl.2_Intron|NEDD4_uc002adi.2_Silent_p.D389D|NEDD4_uc010ugj.1_Silent_p.D389D|NEDD4_uc010bfm.2_Silent_p.D389D|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	389					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		TTGTTTCACAGTCTAATGTAG	0.363													17	38					0	0	0	0	A	56207863	A	A	56207863	2	1	219	1	0	0	0	0	0	0	0	1	10364	1020	36	4		4	NEDD4	15	56207863	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1291776	56207863	46323529	193	40330											
CCDC33	80125	broad.mit.edu	37	chr15	74559050	74559050	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtggtggacaacagaaaGaaacaggagttgttgtccta	15	8	13	5	0	0	2	0	0	0	2	1	4	1	4	1	4	2	2	1	4	5	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:74559050G>A	uc002axo.2	+	4	745	c.351G>A	c.(349-351)AAG>AAA	p.K117K	CCDC33_uc002axp.2_5'UTR	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	320	C2.						protein binding			ovary(3)|skin(2)	5						ACAACAGAAAGAAACAGGAGT	0.473													29	107					0	0	0	0	A	74559050	A	A	74559050	2	1	219	1	0	0	0	0	0	0	0	1	2819	933	33	2		2	CCDC33	15	74559050	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	18351187	74559050	27972342	194	40331											
C15orf27	123591	broad.mit.edu	37	chr15	76467994	76467994	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagcagctggagaggctgacGcagatctgtcaggagcaagg	11	5	17	8	1	2	3	1	1	1	2	2	6	2	4	0	4	3	5	0	4	1	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:76467994G>A	uc002bbq.2	+	8	902	c.747G>A	c.(745-747)ACG>ACA	p.T249T	C15orf27_uc010bkp.2_Silent_p.T65T|C15orf27_uc002bbr.2_Silent_p.T65T	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	249	Potential.					integral to membrane					0						AGAGGCTGACGCAGATCTGTC	0.512													14	55					0	0	0	0	A	76467994	A	A	76467994	2	1	219	1	0	0	0	0	0	0	0	1	1794	1074	38	1		1	C15orf27	15	76467994	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1908944	76467994	26063398	195	40332											
ADAMTS7	11173	broad.mit.edu	37	chr15	79067056	79067056	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacgtggcggaaggaggggcGgccagcagggcaggcctgca	8	2	21	10	3	0	0	0	0	0	0	0	3	0	2	2	8	2	3	2	8	1	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:79067056G>A	uc002bej.3	-	12	1997	c.1786C>T	c.(1786-1788)CGC>TGC	p.R596C	ADAMTS7_uc010und.1_Intron|ADAMTS7_uc002bek.1_Missense_Mutation_p.R596C	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	596	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						AAGGAGGGGCGGCCAGCAGGG	0.632													10	39					0	0	0	0	A	79067056	A	A	79067056	3	1	219	1	0	0	0	0	1	0	0	0	271	1116	39	1	3326	1	ADAMTS7	15	79067056	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	2599062	79067056	23464336	196	40333											
AP3B2	8120	broad.mit.edu	37	chr15	83335612	83335612	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgatgagctgccgggtgaagCgcgcccggtcgcgaatatca	8	6	15	12	7	1	2	1	2	0	0	2	4	1	2	2	2	3	1	2	2	3	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr15:83335612C>T	uc010uoh.1	-	15	1916	c.1739G>A	c.(1738-1740)CGC>CAC	p.R580H	AP3B2_uc010uoi.1_Missense_Mutation_p.R580H|AP3B2_uc010uoj.1_Missense_Mutation_p.R548H|AP3B2_uc010uog.1_Missense_Mutation_p.R216H	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	580					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			CCGGGTGAAGCGCGCCCGGTC	0.597													17	66					0	0	0	0	T	83335612	T	T	83335612	3	4	219	1	0	0	0	0	1	0	0	0	745	768	27	1	1557	1	AP3B2	15	83335612	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	4268556	83335612	19195780	197	40334											
TPSD1	23430	broad.mit.edu	37	chr16	1306640	1306640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatgcacttctgcgggggctCcctcatccacccccagtggg	5	8	12	16	1	2	0	1	0	1	0	4	1	4	0	4	3	2	2	4	3	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:1306640C>T	uc002clb.1	+	2	215	c.206C>T	c.(205-207)TCC>TTC	p.S69F	TPSD1_uc010brm.1_Missense_Mutation_p.S7F	NM_012217	NP_036349	Q9BZJ3	TRYD_HUMAN	tryptase delta 1 precursor	69	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				TGCGGGGGCTCCCTCATCCAC	0.687													22	57					0	0	0	0	T	1306640	T	T	1306640	3	4	219	1	0	0	0	0	1	0	0	0	16492	855	30	2	212	2	TPSD1	16	1306640	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08		1306640	89048113	198	40335											
MAPK8IP3	23162	broad.mit.edu	37	chr16	1812845	1812845	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctctggcagcttcagccGcctcttcagctcttcctcca	4	12	7	18	1	5	0	2	0	3	0	7	0	7	0	5	1	4	3	5	1	0	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:1812845G>A	uc002cmk.2	+	16	1853	c.1733G>A	c.(1732-1734)CGC>CAC	p.R578H	MAPK8IP3_uc002cml.2_Missense_Mutation_p.R572H|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.R579H	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	578					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						AGCTTCAGCCGCCTCTTCAGC	0.677													28	66					0	0	0	0	A	1812845	A	A	1812845	3	1	219	1	0	0	0	0	1	0	0	0	9339	1087	38	1	1811	1	MAPK8IP3	16	1812845	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	506205	1812845	88541908	199	40336											
CREBBP	1387	broad.mit.edu	37	chr16	3777767	3777767	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgtcccccgtggtgtccccGaccagggacagttcgctgga	5	8	14	14	3	0	0	0	0	0	0	3	3	2	2	5	3	0	2	5	3	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:3777767G>A	uc002cvv.2	-	31	7485	c.7281C>T	c.(7279-7281)GTC>GTT	p.V2427V	CREBBP_uc002cvw.2_Silent_p.V2389V	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	2427					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGGTGTCCCCGACCAGGGACA	0.562			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				36	131					0	0	0	0	A	3777767	A	A	3777767	2	1	219	1	0	0	0	0	0	0	0	1	3876	1045	37	1		1	CREBBP	16	3777767	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1964922	3777767	86576986	200	40337											
GRIN2A	2903	broad.mit.edu	37	chr16	9857127	9857127	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cataaggcataacatgctccGaaatatacacatcattgtgg	15	10	7	9	1	1	0	1	0	0	0	2	1	2	0	1	2	3	2	1	2	5	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:9857127G>C	uc002czo.3	-	13	4822	c.4274C>G	c.(4273-4275)TCG>TGG	p.S1425W	GRIN2A_uc010uym.1_Missense_Mutation_p.S1425W|GRIN2A_uc010uyn.1_3'UTR|GRIN2A_uc002czr.3_3'UTR	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1425	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.S1425L(1)		skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AACATGCTCCGAAATATACAC	0.473													17	34					0	0	0	0	C	9857127	C	C	9857127	3	2	219	1	0	0	0	0	1	0	0	0	6818	1059	37	3	124	3	GRIN2A	16	9857127	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	6079360	9857127	80497626	201	40338											
MYH11	4629	broad.mit.edu	37	chr16	15832485	15832485	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtaagattcttggccttttCttcctcttctgcaagatttg	6	18	8	9	0	4	2	0	0	4	2	5	2	5	2	2	2	1	2	2	2	2	8			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:15832485C>T	uc002ddy.2	-	24	3165	c.3058G>A	c.(3058-3060)GAA>AAA	p.E1020K	MYH11_uc002ddv.2_Missense_Mutation_p.E1027K|MYH11_uc002ddw.2_Missense_Mutation_p.E1020K|MYH11_uc002ddx.2_Missense_Mutation_p.E1027K|MYH11_uc010bvg.2_Missense_Mutation_p.E852K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1020	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TTGGCCTTTTCTTCCTCTTCT	0.358			T	CBFB	AML								12	71					0	0	0	0	T	15832485	T	T	15832485	3	4	219	1	0	0	0	0	1	0	0	0	10084	922	32	2	2967	2	MYH11	16	15832485	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	5975358	15832485	74522268	202	40339											
DNAH3	55567	broad.mit.edu	37	chr16	20981224	20981224	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctgcatcgacttcaccagcGagatgtcggccgggttcagg	7	9	13	12	4	3	1	2	0	1	1	5	3	3	1	2	3	2	2	2	3	0	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:20981224G>A	uc010vbe.1	-	52	8348	c.8348C>T	c.(8347-8349)TCG>TTG	p.S2783L	DNAH3_uc010vbd.1_Missense_Mutation_p.S218L	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2783	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTTCACCAGCGAGATGTCGGC	0.592													35	86					0	0	0	0	A	20981224	A	A	20981224	3	1	219	1	0	0	0	0	1	0	0	0	4625	1059	37	1	4045	1	DNAH3	16	20981224	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	5148739	20981224	69373529	203	40340											
CD19	930	broad.mit.edu	37	chr16	28948971	28948971	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttatgagaacgaggatgaaGagctgacccagccggtcgcc	11	6	13	11	3	0	4	0	3	0	2	1	7	0	5	3	2	3	1	3	2	3	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:28948971G>A	uc002drs.2	+	11	1461	c.1399G>A	c.(1399-1401)GAG>AAG	p.E467K	uc010vct.1_Intron|CD19_uc010byo.1_Missense_Mutation_p.E467K	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	467	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						CGAGGATGAAGAGCTGACCCA	0.567													19	35					0	0	0	0	A	28948971	A	A	28948971	3	1	219	1	0	0	0	0	1	0	0	0	2988	943	33	2	1441	2	CD19	16	28948971	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	7967747	28948971	61405782	204	40341											
KCTD13	253980	broad.mit.edu	37	chr16	29918300	29918300	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggttctcttcatcctcccCgcggccagccccaccagctc	4	9	7	21	3	2	0	1	0	1	0	7	0	4	0	7	2	2	2	7	2	0	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:29918300C>T	uc002duv.2	-	6	1074	c.883G>A	c.(883-885)GGG>AGG	p.G295R	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ASPHD1_uc002duu.3_Intron|ASPHD1_uc010bzi.2_Intron|KCTD13_uc010vee.1_RNA	NM_178863	NP_849194	Q8WZ19	BACD1_HUMAN	potassium channel tetramerisation domain	295					cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0						TCATCCTCCCCGCGGCCAGCC	0.637													33	80					0	0	0	0	T	29918300	T	T	29918300	3	4	219	1	0	0	0	0	1	0	0	0	8139	652	23	1	110	1	KCTD13	16	29918300	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	969329	29918300	60436453	205	40342											
SALL1	6299	broad.mit.edu	37	chr16	51174819	51174819	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctcatcggaagtacttttCgcttcaaaggcagtgacatt	10	12	9	10	2	2	1	2	1	0	0	4	2	2	2	1	2	1	3	1	2	3	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:51174819C>T	uc010vgs.1	-	2	1345	c.1314G>A	c.(1312-1314)GCG>GCA	p.A438A	SALL1_uc010vgr.1_Silent_p.A341A|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	438					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			AAGTACTTTTCGCTTCAAAGG	0.488													33	95					0	0	0	0	T	51174819	T	T	51174819	2	4	219	1	0	0	0	0	0	0	0	1	13875	871	31	1		1	SALL1	16	51174819	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	21256519	51174819	39179934	206	40343											
CKLF	51192	broad.mit.edu	37	chr16	66597116	66597116	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cacaacattgacagttggtgGaggggtaagtggaagtcttt	11	11	14	5	0	1	1	0	1	1	0	1	3	1	3	0	5	1	2	0	5	3	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:66597116G>A	uc002eow.2	+	3	476	c.329G>A	c.(328-330)GGA>GAA	p.G110E	CKLF_uc002eox.1_Missense_Mutation_p.G110E|CKLF_uc002eot.2_Intron|CKLF_uc002eou.2_Missense_Mutation_p.G57E|CKLF_uc002eov.2_Intron	NM_016951	NP_058647	Q9UBR5	CKLF_HUMAN	chemokine-like factor isoform a	110	Helical; (Potential).|MARVEL.				cell proliferation|lymphocyte chemotaxis|macrophage chemotaxis|neutrophil chemotaxis|secretion by cell	extracellular space|integral to membrane	chemokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0689)|Epithelial(162;0.217)		ACAGTTGGTGGAGGGGTAAGT	0.368													8	35					0	0	0	0	A	66597116	A	A	66597116	3	1	219	1	0	0	0	0	1	0	0	0	3462	1174	41	2	339	2	CKLF	16	66597116	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	15422297	66597116	23757637	207	40344											
DYNC1LI2	1783	broad.mit.edu	37	chr16	66766353	66766353	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtttttctcttctttcactGatgtgtaaatcaaggcagct	8	17	8	8	0	4	1	2	1	2	0	5	1	4	1	0	2	1	4	0	2	3	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:66766353G>C	uc002eqb.1	-	7	849	c.818C>G	c.(817-819)TCA>TGA	p.S273*	DYNC1LI2_uc010vis.1_Nonsense_Mutation_p.S196*|DYNC1LI2_uc010vit.1_Nonsense_Mutation_p.S273*|DYNC1LI2_uc010viu.1_Nonsense_Mutation_p.S234*	NM_006141	NP_006132	O43237	DC1L2_HUMAN	dynein, cytoplasmic, light intermediate	273					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|skin(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		TTCTTTCACTGATGTGTAAAT	0.378													11	17					0	0	0	0	C	66766353	C	C	66766353	4	2	219	1	0	0	0	0	0	1	0	0	4867	1294	45	2	688	2	DYNC1LI2	16	66766353	Nonsense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	169237	66766353	23588400	208	40345											
SLC12A4	6560	broad.mit.edu	37	chr16	67979293	67979293	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttaatgtgcaccagctccCggaaattgtcaggggcatgg	9	9	13	10	1	1	0	1	0	0	0	2	1	2	1	2	4	2	4	2	4	2	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:67979293C>G	uc002euz.2	-	22	3152	c.3011G>C	c.(3010-3012)CGG>CCG	p.R1004P	LCAT_uc002euy.1_5'Flank|SLC12A4_uc010ceu.2_Missense_Mutation_p.R998P|SLC12A4_uc010vkh.1_Missense_Mutation_p.R973P|SLC12A4_uc010vki.1_Missense_Mutation_p.R998P|SLC12A4_uc010vkj.1_Missense_Mutation_p.R1006P|SLC12A4_uc002eva.2_Missense_Mutation_p.R1004P	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	1004	Cytoplasmic (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CACCAGCTCCCGGAAATTGTC	0.572													28	58					0	0	0	0	G	67979293	G	G	67979293	3	3	219	1	0	0	0	0	1	0	0	0	14450	652	23	3	258	3	SLC12A4	16	67979293	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1212940	67979293	22375460	209	40346											
SLC7A6OS	84138	broad.mit.edu	37	chr16	68344297	68344297	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcgtggacaaggtctaacaActgaaagcccgagttcccgg	11	7	11	12	3	1	1	0	1	1	0	3	3	2	2	2	3	3	1	2	3	4	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr16:68344297A>G	uc002evw.1	-	2	431	c.412T>C	c.(412-414)TTG>CTG	p.L138L	PRMT7_uc002evx.1_5'Flank|PRMT7_uc002evy.1_5'Flank|PRMT7_uc010vlg.1_5'Flank	NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	138					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		AGGTCTAACAACTGAAAGCCC	0.627													10	12					0	0	0	0	G	68344297	G	G	68344297	2	3	219	1	0	0	0	0	0	0	0	1	14766	40	2	5		5	SLC7A6OS	16	68344297	Silent	SNP	A	TCGA-CV-7095-01A-21D-2012-08	365004	68344297	22010456	210	40347											
YWHAE	7531	broad.mit.edu	37	chr17	1303386	1303386	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcttcgcctggtacaccaGatcctctcgatcatccatag	9	10	7	15	2	2	1	1	0	1	1	6	2	4	1	4	1	2	2	4	1	2	3	rs11552915		TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:1303386G>C	uc002fsj.2	-	1	171	c.19C>G	c.(19-21)CTG>GTG	p.L7V	YWHAE_uc002fsk.2_Translation_Start_Site|YWHAE_uc010vqh.1_RNA|YWHAE_uc010vqi.1_RNA	NM_006761	NP_006752	P62258	1433E_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	7					apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding			lung(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)		TGGTACACCAGATCCTCTCGA	0.662													19	99					0	0	0	0	C	1303386	C	C	1303386	3	2	219	1	0	0	0	0	1	0	0	0	17570	933	33	2	772	2	YWHAE	17	1303386	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08		1303386	79891824	211	40348											
MNT	4335	broad.mit.edu	37	chr17	2298449	2298449	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgctgagtccgggggcgcCaaccagggccggctgacgag	8	4	17	12	4	0	2	0	2	0	0	1	3	1	2	4	4	2	2	4	4	2	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:2298449C>T	uc002fur.2	-	2	625	c.373G>A	c.(373-375)GGC>AGC	p.G125S		NM_020310	NP_064706	Q99583	MNT_HUMAN	MAX binding protein	125					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			skin(1)	1				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		CCGGGGGCGCCAACCAGGGCC	0.542													4	7					0	0	0	0	T	2298449	T	T	2298449	3	4	219	1	0	0	0	0	1	0	0	0	9731	594	21	4	1395	4	MNT	17	2298449	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	995063	2298449	78896761	212	40349											
ASPA	443	broad.mit.edu	37	chr17	3385074	3385074	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaataactttttaattcaGatgtttcattacattaaggt	14	17	6	4	0	2	1	2	0	0	1	2	2	2	2	0	2	2	1	0	2	5	8			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:3385074G>C	uc010ckg.2	+	3	505	c.414G>C	c.(412-414)CAG>CAC	p.Q138H	SPATA22_uc010vrg.1_Intron|ASPA_uc002fvq.2_Missense_Mutation_p.Q138H	NM_001128085	NP_001121557	P45381	ACY2_HUMAN	aspartoacylase	138					aspartate catabolic process	cytoplasm|nucleus	aminoacylase activity|aspartoacylase activity|hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	TTTTAATTCAGATGTTTCATT	0.318													3	22					0	0	0	0	C	3385074	C	C	3385074	3	2	219	1	0	0	0	0	1	0	0	0	1052	933	33	2	420	2	ASPA	17	3385074	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1086625	3385074	77810136	213	40350											
PITPNM3	83394	broad.mit.edu	37	chr17	6373604	6373604	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaggatgaaggccaccacGtctgtggactcccagtaact	10	8	10	13	1	2	1	1	1	1	0	3	3	3	3	3	3	1	1	3	3	2	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:6373604G>A	uc002gdd.3	-	13	1900	c.1749C>T	c.(1747-1749)GAC>GAT	p.D583D	PITPNM3_uc010cln.2_Silent_p.D547D|PITPNM3_uc010clm.2_Silent_p.D66D|PITPNM3_uc002gdc.3_Silent_p.D174D	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	583	DDHD.				phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		AGGCCACCACGTCTGTGGACT	0.652													5	16					0	0	0	0	A	6373604	A	A	6373604	2	1	219	1	0	0	0	0	0	0	0	1	12007	1136	40	1		1	PITPNM3	17	6373604	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	2988530	6373604	74821606	214	40351											
C17orf74	201243	broad.mit.edu	37	chr17	7329885	7329885	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggaggaggaggacaacctgcCcttcccgtatcccaagtacc	10	6	11	14	1	0	0	0	0	0	0	2	4	2	4	5	4	3	2	5	4	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:7329885C>T	uc002ggw.2	+	3	648	c.575C>T	c.(574-576)CCC>CTC	p.P192L	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	192						integral to membrane					0		Prostate(122;0.157)				GACAACCTGCCCTTCCCGTAT	0.597													33	157					0	0	0	0	T	7329885	T	T	7329885	3	4	219	1	0	0	0	0	1	0	0	0	1887	623	22	4	585	4	C17orf74	17	7329885	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	956281	7329885	73865325	215	40352											
C17orf74	201243	broad.mit.edu	37	chr17	7330746	7330746	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcagagccaggtccagctCactgccaccggcttccacct	8	6	10	17	1	1	1	1	0	0	1	3	2	3	1	6	2	4	3	6	2	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:7330746C>T	uc002ggw.2	+	3	1509	c.1436C>T	c.(1435-1437)TCA>TTA	p.S479L	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	479						integral to membrane					0		Prostate(122;0.157)				AGGTCCAGCTCACTGCCACCG	0.632													13	32					0	0	0	0	T	7330746	T	T	7330746	3	4	219	1	0	0	0	0	1	0	0	0	1887	838	29	2	1446	2	C17orf74	17	7330746	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	861	7330746	73864464	216	40353											
TP53	7157	broad.mit.edu	37	chr17	7578263	7578263	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgcaaatttccttccactcGgataagatgctgaggagggg	11	9	12	9	2	0	2	0	1	0	1	3	4	2	4	2	4	1	2	2	4	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:7578263G>A	uc002gim.2	-	6	780	c.586C>T	c.(586-588)CGA>TGA	p.R196*	TP53_uc002gig.1_Nonsense_Mutation_p.R196*|TP53_uc002gih.2_Nonsense_Mutation_p.R196*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R64*|TP53_uc010cng.1_Nonsense_Mutation_p.R64*|TP53_uc002gii.1_Nonsense_Mutation_p.R64*|TP53_uc010cnh.1_Nonsense_Mutation_p.R196*|TP53_uc010cni.1_Nonsense_Mutation_p.R196*|TP53_uc002gij.2_Nonsense_Mutation_p.R196*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R103*|TP53_uc002gio.2_Nonsense_Mutation_p.R64*|TP53_uc010vug.1_Nonsense_Mutation_p.R157*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(125)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.R196L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R64*(1)|p.I195fs*12(1)|p.R103*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	44					0	0	0	0	A	7578263	A	A	7578263	4	1	219	1	0	0	0	0	0	1	0	0	16448	1124	39	1	708	1	TP53	17	7578263	Nonsense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	247517	7578263	73616947	217	40354											
DNAH2	146754	broad.mit.edu	37	chr17	7696466	7696466	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccctggagctgatccgcctCtggattgactatggcttctg	5	12	11	13	1	2	2	0	2	2	0	3	4	3	4	4	3	1	2	4	3	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:7696466C>T	uc002giu.1	+	47	7526	c.7512C>T	c.(7510-7512)CTC>CTT	p.L2504L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2504	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGATCCGCCTCTGGATTGACT	0.517													22	84					0	0	0	0	T	7696466	T	T	7696466	2	4	219	1	0	0	0	0	0	0	0	1	4624	900	32	2		2	DNAH2	17	7696466	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	118203	7696466	73498744	218	40355											
ALOXE3	59344	broad.mit.edu	37	chr17	8021162	8021162	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtctcctttgtactcacCgatccaggggcgaagtccct	6	11	9	15	2	2	0	1	0	1	0	5	2	4	0	5	2	1	1	5	2	2	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:8021162C>T	uc010cnr.2	-	2	517	c.147G>A	c.(145-147)TCG>TCA	p.S49S	ALOXE3_uc002gka.2_Silent_p.S205S|ALOXE3_uc010vuo.1_Silent_p.S181S|ALOXE3_uc010vup.1_RNA	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	49	PLAT.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						TTGTACTCACCGATCCAGGGG	0.612													4	24					0	0	0	0	T	8021162	T	T	8021162	2	4	219	1	0	0	0	0	0	0	0	1	542	666	23	1		1	ALOXE3	17	8021162	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	324696	8021162	73174048	219	40356											
WDR16	146845	broad.mit.edu	37	chr17	9545105	9545105	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggaaggttccctgtctgggtCgataaatggcatggatatca	10	11	13	7	1	2	0	1	0	1	0	4	3	3	2	1	5	0	2	1	5	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:9545105C>G	uc002gly.2	+	13	1709	c.1640C>G	c.(1639-1641)TCG>TGG	p.S547W	WDR16_uc002glz.2_Missense_Mutation_p.S479W|WDR16_uc010coc.2_Missense_Mutation_p.S557W	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	547	WD 10.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CTGTCTGGGTCGATAAATGGC	0.458													20	71					0	0	0	0	G	9545105	G	G	9545105	3	3	219	1	0	0	0	0	1	0	0	0	17344	893	31	3	1690	3	WDR16	17	9545105	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1523943	9545105	71650105	220	40357											
MYH3	4621	broad.mit.edu	37	chr17	10547749	10547749	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatccagttgctggttaatGcgagtgaccatccacaagaa	12	10	10	9	1	0	2	0	1	0	1	2	3	2	2	3	1	2	4	3	1	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:10547749G>A	uc002gmq.1	-	13	1406	c.1329C>T	c.(1327-1329)CGC>CGT	p.R443R		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	443	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						GCTGGTTAATGCGAGTGACCA	0.398													22	68					0	0	0	0	A	10547749	A	A	10547749	2	1	219	1	0	0	0	0	0	0	0	1	10089	1306	46	4		4	MYH3	17	10547749	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1002644	10547749	70647461	221	40358											
MYOCD	93649	broad.mit.edu	37	chr17	12642624	12642624	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcccccccagcacccccatAgccgtgcatgctgctgtaaa	8	6	9	18	1	0	0	0	0	0	0	0	0	0	0	6	1	5	5	6	1	3	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:12642624A>T	uc002gnn.2	+	7	995	c.696A>T	c.(694-696)ATA>ATT	p.I232I	MYOCD_uc002gno.2_Silent_p.I232I|MYOCD_uc002gnp.1_Silent_p.I136I	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	232					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GCACCCCCATAGCCGTGCATG	0.587													32	39					0	0	0	0	T	12642624	T	T	12642624	2	4	219	1	0	0	0	0	0	0	0	1	10140	410	15	5		5	MYOCD	17	12642624	Silent	SNP	A	TCGA-CV-7095-01A-21D-2012-08	2094875	12642624	68552586	222	40359											
KCNJ12	3768	broad.mit.edu	37	chr17	21318895	21318895	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgtggacatccgctggCggtacatgctgctcatcttc	5	12	11	13	2	2	0	1	0	1	0	4	1	3	1	2	3	3	4	2	3	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:21318895C>T	uc002gyv.1	+	3	946	c.241C>T	c.(241-243)CGG>TGG	p.R81W		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	81	Helical; Name=M1; (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CATCCGCTGGCGGTACATGCT	0.577										Prostate(3;0.18)			9	89					0	0	0	0	T	21318895	T	T	21318895	3	4	219	1	0	0	0	0	1	0	0	0	8085	759	27	1	243	1	KCNJ12	17	21318895	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	8676271	21318895	59876315	223	40360											
WSB1	26118	broad.mit.edu	37	chr17	25628934	25628934	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atactttgcttggtcacaagGacatcgcacagtaaagcttg	12	11	9	9	1	1	0	1	0	0	0	2	1	1	1	0	2	3	4	0	2	4	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:25628934G>T	uc002gzd.1	+	2	477	c.161G>T	c.(160-162)GGA>GTA	p.G54V	WSB1_uc010vzy.1_Missense_Mutation_p.G54V|WSB1_uc010vzz.1_Missense_Mutation_p.G23V|WSB1_uc010crf.1_Intron|WSB1_uc002gze.1_Intron|WSB1_uc002gzf.1_RNA	NM_015626	NP_056441	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box-containing 1 isoform 1	54	WD 1.				intracellular signal transduction	intracellular	protein binding				0	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		TGGTCACAAGGACATCGCACA	0.413													35	201					3.76114e-14	4.19791e-14	1	0	T	25628934	T	T	25628934	3	4	219	1	0	0	0	0	1	0	0	0	17472	1174	41	2	167	2	WSB1	17	25628934	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	4310039	25628934	55566276	224	40361											
TMEM99	147184	broad.mit.edu	37	chr17	38991082	38991082	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgtctccttggtgttggctCgtggttgctcttcaacaact	4	17	10	10	1	3	0	1	0	2	0	5	0	3	0	1	3	3	4	1	3	2	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:38991082C>T	uc002hvj.1	+	3	621	c.314C>T	c.(313-315)TCG>TTG	p.S105L		NM_145274	NP_660317	Q8N816	TMM99_HUMAN	transmembrane protein 99 precursor	105	Helical; (Potential).					integral to membrane				skin(1)	1		Breast(137;0.000301)				GGTGTTGGCTCGTGGTTGCTC	0.468													62	129					0	0	0	0	T	38991082	T	T	38991082	3	4	219	1	0	0	0	0	1	0	0	0	16292	893	31	1	316	1	TMEM99	17	38991082	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	13362148	38991082	42204128	225	40362											
KCTD2	23510	broad.mit.edu	37	chr17	73049121	73049121	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttccaggtgtgctggaggAagcggagttttacaacatcg	9	11	14	7	2	0	0	0	0	0	0	2	3	1	3	1	4	4	3	1	4	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:73049121A>T	uc002jmp.2	+	3	528	c.461A>T	c.(460-462)GAA>GTA	p.E154V	KCTD2_uc010dfz.2_RNA|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	154	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					GTGCTGGAGGAAGCGGAGTTT	0.463													20	21					0	0	0	0	T	73049121	T	T	73049121	3	4	219	1	0	0	0	0	1	0	0	0	8146	246	9	5	471	5	KCTD2	17	73049121	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	34058039	73049121	8146089	226	40363											
TRIM65	201292	broad.mit.edu	37	chr17	73888194	73888194	+	Frame_Shift_Del	DEL	G	-	-																															caactgcttcaggtcacccaGctgttggtcttcatcccact																										TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:73888194delG	uc002jpx.2	-	4	853	c.817delC	c.(817-819)CTGfs	p.L273fs		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	273						intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGGTCACCCAGCTGTTGGTCT	0.632													---	---	---								-	73888194	-	-	73888194	7	5	219	1	0	1	0	1	0	0	0	0	16606	962	34	0	748	0	TRIM65	17	73888194	Frame_Shift_Del	DEL	G	TCGA-CV-7095-01A-21D-2012-08	839073	73888194	7307016	227	40364											
CANT1	124583	broad.mit.edu	37	chr17	76991155	76991155	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtagttggacacccagttCtcgtggtccacgctgccctt	5	13	10	13	2	1	0	0	0	1	0	3	1	2	1	3	2	1	4	3	2	1	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:76991155C>T	uc002jwn.2	-	5	1219	c.780G>A	c.(778-780)GAG>GAA	p.E260E	CANT1_uc002jwk.2_Silent_p.E260E|CANT1_uc002jwj.2_Silent_p.E260E|CANT1_uc002jwl.2_Intron|CANT1_uc002jwm.1_RNA	NM_001159772	NP_001153244	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	260	Lumenal (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity				0			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			ACACCCAGTTCTCGTGGTCCA	0.652			T	ETV4	prostate								6	13					0	0	0	0	T	76991155	T	T	76991155	2	4	219	1	0	0	0	0	0	0	0	1	2629	912	32	2		2	CANT1	17	76991155	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	3102961	76991155	4204055	228	40365											
SLC25A10	1468	broad.mit.edu	37	chr17	79673961	79673961	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaagaagatatccccatagCgaaagaacggacacatttca	17	6	9	9	2	1	3	1	0	0	3	2	6	2	5	2	2	2	0	2	2	6	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr17:79673961C>T	uc010wut.1	+	4	496	c.371C>T	c.(370-372)GCG>GTG	p.A124V	MRPL12_uc002kbh.1_Missense_Mutation_p.A124V	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier;	Error:Variant_position_missing_in_Q9UBX3_after_alignment					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	ATCCCCATAGCGAAAGAACGG	0.562													17	13					0	0	0	0	T	79673961	T	T	79673961	3	4	219	1	0	0	0	0	1	0	0	0	14536	768	27	1		1	SLC25A10	17	79673961	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	2682806	79673961	1521249	229	40366											
COLEC12	81035	broad.mit.edu	37	chr18	335145	335145	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggtccaggctcccccttCtctcctttctgtcccttgtt	1	16	8	16	0	2	0	0	0	2	0	7	0	6	0	5	3	0	2	5	3	0	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr18:335145C>A	uc002kkm.2	-	6	1628	c.1413G>T	c.(1411-1413)GAG>GAT	p.E471D		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	471	Collagen-like 1.|Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GCTCCCCCTTCTCTCCTTTCT	0.632													14	42					0.00185496	0.00198091	1	0	A	335145	A	A	335145	3	1	219	1	0	0	0	0	1	0	0	0	3727	912	32	2	835	2	COLEC12	18	335145	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08		335145	77742103	230	40367											
ZNF521	25925	broad.mit.edu	37	chr18	22806343	22806343	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatagcaatggggacaaaaGaatgcattactatctttagc	16	11	8	6	0	1	1	0	0	1	1	1	2	1	2	0	2	4	2	0	2	9	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr18:22806343G>C	uc002kvk.2	-	4	1786	c.1539C>G	c.(1537-1539)TTC>TTG	p.F513L	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.F513L|ZNF521_uc002kvl.2_Missense_Mutation_p.F293L	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	513	C2H2-type 12.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GGGGACAAAAGAATGCATTAC	0.458			T	PAX5	ALL								21	51					0	0	0	0	C	22806343	C	C	22806343	3	2	219	1	0	0	0	0	1	0	0	0	18032	933	33	2	2416	2	ZNF521	18	22806343	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	22471198	22806343	55270905	231	40368											
CXXC1	30827	broad.mit.edu	37	chr18	47810844	47810844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaggcactggggcagtgacGcagggtccttggcatcagcc	7	6	15	13	1	1	1	1	1	0	0	2	1	2	1	3	5	1	4	3	5	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr18:47810844G>A	uc002leq.3	-	9	1842	c.1109C>T	c.(1108-1110)GCG>GTG	p.A370V	MBD1_uc002leg.2_5'Flank|MBD1_uc010dow.1_5'Flank|MBD1_uc002leh.3_5'Flank|MBD1_uc002len.2_5'Flank|MBD1_uc002lei.3_5'Flank|MBD1_uc002lej.3_5'Flank|MBD1_uc002lek.3_5'Flank|MBD1_uc002lel.3_5'Flank|MBD1_uc002lem.3_5'Flank|MBD1_uc010xdj.1_5'Flank|MBD1_uc010xdk.1_5'Flank|MBD1_uc002leo.2_5'Flank|CXXC1_uc002lep.3_Missense_Mutation_p.A227V|CXXC1_uc002ler.3_Missense_Mutation_p.A374V|CXXC1_uc010doy.2_Missense_Mutation_p.A370V|CXXC1_uc002les.2_Missense_Mutation_p.A370V	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	370					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GGGCAGTGACGCAGGGTCCTT	0.597													13	120					0	0	0	0	A	47810844	A	A	47810844	3	1	219	1	0	0	0	0	1	0	0	0	4114	1087	38	1	889	1	CXXC1	18	47810844	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	25004501	47810844	30266404	232	40369											
ME2	4200	broad.mit.edu	37	chr18	48447048	48447048	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagggacagctgcagtagctCtagcaggtcttcttgcagca	9	9	12	11	0	3	0	0	0	3	0	3	1	3	1	0	2	6	7	0	2	2	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr18:48447048C>G	uc002ley.2	+	9	1118	c.862C>G	c.(862-864)CTA>GTA	p.L288V	ME2_uc010dpd.2_Missense_Mutation_p.L288V	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	288					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	TGCAGTAGCTCTAGCAGGTCT	0.348													40	50					0	0	0	0	G	48447048	G	G	48447048	3	3	219	1	0	0	0	0	1	0	0	0	9471	912	32	2	892	2	ME2	18	48447048	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	636204	48447048	29630200	233	40370											
ONECUT2	9480	broad.mit.edu	37	chr18	55143901	55143901	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctggagaagtggcaagaCgatctgagcacagggggctc	11	5	16	9	1	1	3	0	1	1	2	2	5	1	3	1	4	2	3	1	4	2	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr18:55143901C>T	uc002lgo.2	+	2	1493	c.1461C>T	c.(1459-1461)GAC>GAT	p.D487D		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	487					organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		AGTGGCAAGACGATCTGAGCA	0.572													7	35					0	0	0	0	T	55143901	T	T	55143901	2	4	219	1	0	0	0	0	0	0	0	1	10923	535	19	1		1	ONECUT2	18	55143901	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	6696853	55143901	22933347	234	40371											
DOK6	220164	broad.mit.edu	37	chr18	67365664	67365664	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attcaacgtgtatcttatgcCtacaccaaacctggatattt	12	14	5	10	1	2	0	1	0	1	0	2	1	2	1	3	1	4	1	3	1	6	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr18:67365664C>G	uc002lkl.2	+	5	624	c.434C>G	c.(433-435)CCT>CGT	p.P145R		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	145	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TATCTTATGCCTACACCAAAC	0.398													11	37					0	0	0	0	G	67365664	G	G	67365664	3	3	219	1	0	0	0	0	1	0	0	0	4723	681	24	4	452	4	DOK6	18	67365664	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	12221763	67365664	10711584	235	40372											
DUS3L	56931	broad.mit.edu	37	chr19	5785684	5785684	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgcgtgtccgagccccAgtgctccaggccgtagttgg	4	8	14	15	3	0	0	0	0	0	0	2	1	2	0	6	2	3	3	6	2	1	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:5785684A>T	uc002mdc.2	-	11	1778	c.1681T>A	c.(1681-1683)TGG>AGG	p.W561R	PRR22_uc002mdb.1_5'Flank|PRR22_uc010xiv.1_5'Flank|DUS3L_uc002mdd.2_Missense_Mutation_p.W319R|DUS3L_uc010duk.2_Missense_Mutation_p.W226R	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	561					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0						TCCGAGCCCCAGTGCTCCAGG	0.677													6	18					0	0	0	0	T	5785684	T	T	5785684	3	4	219	1	0	0	0	0	1	0	0	0	4829	188	7	5	283	5	DUS3L	19	5785684	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08		5785684	53343299	236	40373											
TUBB4	10382	broad.mit.edu	37	chr19	6495873	6495873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtggtcagcttgagggtgcGgaaacagatgtcgtagagtg	9	9	18	5	2	1	3	1	1	0	2	2	4	1	4	0	4	3	2	0	4	2	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:6495873G>A	uc002mfg.1	-	4	744	c.637C>T	c.(637-639)CGC>TGC	p.R213C	TUBB4_uc002mff.1_Missense_Mutation_p.R141C|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	213					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		TTGAGGGTGCGGAAACAGATG	0.627													31	105					0	0	0	0	A	6495873	A	A	6495873	3	1	219	1	0	0	0	0	1	0	0	0	16826	1116	39	1	701	1	TUBB4	19	6495873	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	710189	6495873	52633110	237	40374											
STXBP2	6813	broad.mit.edu	37	chr19	7708073	7708073	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctacgcacctgcatctagCagatgattgtatgaagcact	11	12	8	10	1	2	3	0	2	2	1	2	3	2	3	1	0	4	5	1	0	4	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:7708073C>G	uc002mha.3	+	13	1094	c.1049C>G	c.(1048-1050)GCA>GGA	p.A350G	STXBP2_uc002mhb.3_Missense_Mutation_p.A347G|STXBP2_uc010dvj.2_Intron|STXBP2_uc010xjr.1_Missense_Mutation_p.A361G|STXBP2_uc010dvk.2_Missense_Mutation_p.A318G|STXBP2_uc002mhc.3_Missense_Mutation_p.A118G|STXBP2_uc002mhe.1_5'Flank	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	350					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						CTGCATCTAGCAGATGATTGT	0.587													9	37					0	0	0	0	G	7708073	G	G	7708073	3	3	219	1	0	0	0	0	1	0	0	0	15419	710	25	4	1099	4	STXBP2	19	7708073	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1212200	7708073	51420910	238	40375											
ZNF443	10224	broad.mit.edu	37	chr19	12541320	12541320	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acattcatacggcttctctcCagagtgaattctttcatgta	10	15	6	10	1	4	2	2	1	2	1	6	2	5	2	1	1	1	2	1	1	3	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:12541320C>T	uc002mtu.2	-	4	1864	c.1666G>A	c.(1666-1668)GGA>AGA	p.G556R		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	556					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						GGCTTCTCTCCAGAGTGAATT	0.388													11	49					0	0	0	0	T	12541320	T	T	12541320	3	4	219	1	0	0	0	0	1	0	0	0	17983	603	21	4	353	4	ZNF443	19	12541320	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	4833247	12541320	46587663	239	40376											
DCAF15	90379	broad.mit.edu	37	chr19	14070284	14070284	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccggagaggggacggagccGgaggatggtgagcggggggc	7	3	24	7	4	0	2	0	1	0	1	1	7	1	6	2	10	2	0	2	10	0	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:14070284G>A	uc002mxt.2	+	7	1218	c.1212G>A	c.(1210-1212)CCG>CCA	p.P404P	DCAF15_uc002mxu.2_5'Flank	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	404										central_nervous_system(1)	1						GGACGGAGCCGGAGGATGGTG	0.687													25	49					0	0	0	0	A	14070284	A	A	14070284	2	1	219	1	0	0	0	0	0	0	0	1	4284	1103	39	1		1	DCAF15	19	14070284	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1528964	14070284	45058699	240	40377											
NOTCH3	4854	broad.mit.edu	37	chr19	15276316	15276316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaagtctgtagagcggtttCggatgagaatctaggacaga	12	9	13	7	2	2	3	0	1	2	3	3	6	2	5	1	3	1	2	1	3	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:15276316C>T	uc002nan.2	-	31	5754	c.5678G>A	c.(5677-5679)CGA>CAA	p.R1893Q		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1893	ANK 2.|Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			AGAGCGGTTTCGGATGAGAAT	0.592													6	22					0	0	0	0	T	15276316	T	T	15276316	3	4	219	1	0	0	0	0	1	0	0	0	10604	884	31	1	1299	1	NOTCH3	19	15276316	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1206032	15276316	43852667	241	40378											
CEBPG	1054	broad.mit.edu	37	chr19	33870422	33870422	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcacaagacacactgcagAgagtcaatcagctcaaagaa	19	4	8	10	0	3	3	3	0	0	3	3	4	3	3	0	0	3	3	0	0	5	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:33870422A>T	uc002nup.2	+	2	566	c.277A>T	c.(277-279)AGA>TGA	p.R93*		NM_001806	NP_001797	P53567	CEBPG_HUMAN	CCAAT/enhancer binding protein gamma	93					B cell differentiation|enucleate erythrocyte differentiation|liver development|natural killer cell mediated cytotoxicity|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of DNA binding|positive regulation of DNA repair|positive regulation of interferon-gamma biosynthetic process|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0	Esophageal squamous(110;0.137)					CACACTGCAGAGAGTCAATCA	0.438													9	12					0	0	0	0	T	33870422	T	T	33870422	4	4	219	1	0	0	0	0	0	1	0	0	3218	296	11	5	279	5	CEBPG	19	33870422	Nonsense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	18594106	33870422	25258561	242	40379											
SIPA1L3	23094	broad.mit.edu	37	chr19	38591744	38591744	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttgcaaggccggccagagctCcgaggaggagatgtacaaca	12	5	14	10	2	0	2	0	0	0	2	1	5	1	3	3	4	4	3	3	4	3	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:38591744C>G	uc002ohk.2	+	6	2416	c.1907C>G	c.(1906-1908)TCC>TGC	p.S636C		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	636	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GGCCAGAGCTCCGAGGAGGAG	0.607													8	28					0	0	0	0	G	38591744	G	G	38591744	3	3	219	1	0	0	0	0	1	0	0	0	14396	855	30	2	1921	2	SIPA1L3	19	38591744	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	4721322	38591744	20537239	243	40380											
LIPE	3991	broad.mit.edu	37	chr19	42912238	42912238	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagctcggggtcgatggcaaAgcggccgctggtgaagagag	9	5	18	9	4	0	2	0	1	0	1	2	4	0	2	1	5	2	3	1	5	2	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:42912238A>G	uc002otr.2	-	4	1823	c.1546T>C	c.(1546-1548)TTT>CTT	p.F516L	uc010eif.1_Intron|LIPE_uc002ots.1_Missense_Mutation_p.F261L	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	516					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TCGATGGCAAAGCGGCCGCTG	0.627													14	74					0	0	0	0	G	42912238	G	G	42912238	3	3	219	1	0	0	0	0	1	0	0	0	8863	72	3	5	1712	5	LIPE	19	42912238	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	4320494	42912238	16216745	244	40381											
PPFIA3	8541	broad.mit.edu	37	chr19	49636571	49636571	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagacgctgcagaaagcGgagaccttgcccgagataga	13	4	13	11	3	0	5	0	0	0	5	0	7	0	5	2	1	4	3	2	1	2	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:49636571G>A	uc002pmr.2	+	9	1436	c.1104G>A	c.(1102-1104)GCG>GCA	p.A368A	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010emt.2_Silent_p.A292A|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Silent_p.A236A	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	368	Potential.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		TGCAGAAAGCGGAGACCTTGC	0.677													8	44					0	0	0	0	A	49636571	A	A	49636571	2	1	219	1	0	0	0	0	0	0	0	1	12366	1103	39	1		1	PPFIA3	19	49636571	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	6724333	49636571	9492412	245	40382											
SPIB	6689	broad.mit.edu	37	chr19	50925756	50925756	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggcgtcttctatgacctGgacagctgcaagcattccag	9	10	11	11	1	2	1	0	1	2	0	3	3	3	2	2	2	3	3	2	2	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:50925756G>A	uc002psd.2	+	3	103	c.78G>A	c.(76-78)CTG>CTA	p.L26L	SPIB_uc002pse.2_Silent_p.L26L|SPIB_uc010ycc.1_Nonsense_Mutation_p.W7*	NM_003121	NP_003112	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	26	TAD1 (Acidic).				regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			lung(1)|kidney(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		TCTATGACCTGGACAGCTGCA	0.577													16	21					0	0	0	0	A	50925756	A	A	50925756	2	1	219	1	0	0	0	0	0	0	0	1	15116	1335	47	4		4	SPIB	19	50925756	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1289185	50925756	8203227	246	40383											
SIGLEC12	89858	broad.mit.edu	37	chr19	51994964	51994964	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcctgtgggtactgaggcctCgctttgtggaagctgaggga	6	11	16	8	1	0	2	0	2	0	0	2	4	1	4	2	4	2	3	2	4	2	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:51994964C>T	uc002pwx.1	-	8	1775	c.1719G>A	c.(1717-1719)GCG>GCA	p.A573A	SIGLEC12_uc002pww.1_Silent_p.A455A|SIGLEC12_uc010eoy.1_Silent_p.A300A	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	573	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ACTGAGGCCTCGCTTTGTGGA	0.597													16	159					0	0	0	0	T	51994964	T	T	51994964	2	4	219	1	0	0	0	0	0	0	0	1	14373	871	31	1		1	SIGLEC12	19	51994964	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	1069208	51994964	7134019	247	40384											
ZNF615	284370	broad.mit.edu	37	chr19	52497522	52497522	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttgagctgtgatttcttgagGaaggttttgtcacattcagt	8	17	11	5	0	3	3	2	3	1	0	3	4	3	4	0	2	1	2	0	2	1	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:52497522G>A	uc002pye.1	-	6	1099	c.807C>T	c.(805-807)TTC>TTT	p.F269F	ZNF615_uc002pyf.1_Silent_p.F280F|ZNF615_uc002pyg.1_Silent_p.F161F|ZNF615_uc002pyh.1_Silent_p.F280F|ZNF615_uc010epi.1_Silent_p.F276F|ZNF615_uc010ydg.1_Silent_p.F274F	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	269	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		ATTTCTTGAGGAAGGTTTTGT	0.413													24	220					0	0	0	0	A	52497522	A	A	52497522	2	1	219	1	0	0	0	0	0	0	0	1	18107	1165	41	2		2	ZNF615	19	52497522	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	502558	52497522	6631461	248	40385											
ZNF28	7576	broad.mit.edu	37	chr19	53303120	53303120	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attacacttgtaaggtttctCtccactatgaagcctatgat	11	15	6	9	0	1	2	0	2	1	0	3	2	2	2	2	1	2	2	2	1	5	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:53303120C>G	uc002qad.2	-	4	2098	c.1978G>C	c.(1978-1980)GAG>CAG	p.E660Q	ZNF28_uc002qac.2_Missense_Mutation_p.E607Q|ZNF28_uc010eqe.2_Missense_Mutation_p.E606Q	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	660					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TAAGGTTTCTCTCCACTATGA	0.423													26	231					0	0	0	0	G	53303120	G	G	53303120	3	3	219	1	0	0	0	0	1	0	0	0	17880	922	32	2	182	2	ZNF28	19	53303120	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	805598	53303120	5825863	249	40386											
ZNF415	55786	broad.mit.edu	37	chr19	53612314	53612314	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgccacactctttacatgtGtaaggtttctctccaatatg	9	16	6	10	0	2	0	0	0	2	0	4	0	3	0	2	1	2	2	2	1	4	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:53612314G>T	uc002qax.2	-	7	1477	c.1128C>A	c.(1126-1128)TAC>TAA	p.Y376*	ZNF415_uc002qat.2_Nonsense_Mutation_p.Y340*|ZNF415_uc002qaw.2_Nonsense_Mutation_p.Y328*|ZNF415_uc010yds.1_Nonsense_Mutation_p.Y328*|ZNF415_uc010ydt.1_Nonsense_Mutation_p.Y328*|ZNF415_uc002qau.2_Nonsense_Mutation_p.Y315*|ZNF415_uc002qav.2_Nonsense_Mutation_p.Y340*|ZNF415_uc002qba.2_Nonsense_Mutation_p.Y98*|ZNF415_uc002qay.2_Nonsense_Mutation_p.Y315*|ZNF415_uc002qaz.2_Nonsense_Mutation_p.Y376*	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	376	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		CTTTACATGTGTAAGGTTTCT	0.398													40	41					5.71845e-15	6.40318e-15	1	0	T	53612314	T	T	53612314	4	4	219	1	0	0	0	0	0	1	0	0	17959	1372	48	4	687	4	ZNF415	19	53612314	Nonsense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	309194	53612314	5516669	250	40387											
ZNF765	91661	broad.mit.edu	37	chr19	53912281	53912281	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catagacttcatactggacaGaaaccttacaaatgtgaaga	17	9	7	8	0	1	4	1	1	0	3	1	5	1	5	1	1	3	0	1	1	6	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr19:53912281G>A	uc010ydx.1	+	6	1800	c.1473G>A	c.(1471-1473)CAG>CAA	p.Q491Q	ZNF765_uc002qbm.2_Silent_p.Q491Q|ZNF765_uc002qbn.2_Intron	NM_001040185	NP_001035275	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00379)		ATACTGGACAGAAACCTTACA	0.378													13	98					0	0	0	0	A	53912281	A	A	53912281	2	1	219	1	0	0	0	0	0	0	0	1	18206	933	33	2		2	ZNF765	19	53912281	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	299967	53912281	5216702	251	40388											
SIGLEC1	6614	broad.mit.edu	37	chr20	3669239	3669239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggggcacaggttgaggtctCacatgtggctgcatcaggat	8	10	15	8	0	2	1	2	1	1	0	3	2	2	2	0	6	1	4	0	6	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr20:3669239C>T	uc002wja.2	-	21	5098	c.5098G>A	c.(5098-5100)GAG>AAG	p.E1700K	SIGLEC1_uc002wjb.1_3'UTR|SIGLEC1_uc002wiz.3_Silent_p.V1675V	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1700	Cytoplasmic (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GTTGAGGTCTCACATGTGGCT	0.612													5	18					0	0	0	0	T	3669239	T	T	3669239	3	4	219	1	0	0	0	0	1	0	0	0	14370	835	29	2	35	2	SIGLEC1	20	3669239	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08		3669239	59356281	252	40389											
BFSP1	631	broad.mit.edu	37	chr20	17475534	17475534	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgtaccagctttgtgtcttCcaaaccttttaatggtgcat	8	16	7	10	0	1	0	0	0	1	0	2	0	2	0	3	1	4	3	3	1	3	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr20:17475534C>G	uc002wpo.2	-	8	1222	c.1183G>C	c.(1183-1185)GAA>CAA	p.E395Q	BFSP1_uc002wpp.2_Missense_Mutation_p.E270Q|BFSP1_uc010zrn.1_Missense_Mutation_p.E256Q|BFSP1_uc010zro.1_Missense_Mutation_p.E256Q	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	395	Tail.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						TTTGTGTCTTCCAAACCTTTT	0.413													48	74					0	0	0	0	G	17475534	G	G	17475534	3	3	219	1	0	0	0	0	1	0	0	0	1418	864	30	2	818	2	BFSP1	20	17475534	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	13806295	17475534	45549986	253	40390											
SUN5	140732	broad.mit.edu	37	chr20	31590695	31590695	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggaggtgtcctctgccatCctgctggtgttccggcctcg	2	11	15	13	2	1	0	0	0	1	0	5	1	4	1	5	5	2	2	5	5	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr20:31590695C>T	uc002wyi.2	-	2	201	c.108G>A	c.(106-108)AGG>AGA	p.R36R		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	36					spermatogenesis					skin(1)	1						CCTCTGCCATCCTGCTGGTGT	0.403													19	49					0	0	0	0	T	31590695	T	T	31590695	2	4	219	1	0	0	0	0	0	0	0	1	15460	854	30	2		2	SUN5	20	31590695	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	14115161	31590695	31434825	254	40391											
BPIL1	80341	broad.mit.edu	37	chr20	31606867	31606867	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctggggtgctgatttcaGaggtcggatgacaacctgct	7	10	15	9	1	1	3	1	2	0	1	2	4	1	4	2	5	3	2	2	5	1	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr20:31606867G>A	uc002wyj.2	+	10	1050	c.856_splice	c.e10-1	p.R286_splice		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing							extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						GCTGATTTCAGAGGTCGGATG	0.572													44	83					0	0	0	0	A	31606867	A	A	31606867	5	1	219	1	0	0	0	0	0	0	1	0	1496	956	33	2	889	2	BPIL1	20	31606867	Splice_Site	SNP	G	TCGA-CV-7095-01A-21D-2012-08	16172	31606867	31418653	255	40392											
OSBPL2	9885	broad.mit.edu	37	chr20	60835072	60835072	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcttctggggaattttcaGaggcaaatcagaaagtcacg	13	10	10	8	1	5	2	3	0	2	2	5	3	5	3	0	3	0	1	0	3	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr20:60835072G>A	uc002yck.1	+	3	275	c.73G>A	c.(73-75)GAG>AAG	p.E25K	OSBPL2_uc002ycl.1_Splice_Site_p.E13_splice|OSBPL2_uc011aah.1_Intron	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	25					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GGAATTTTCAGAGGCAAATCA	0.423													23	55					0	0	0	0	A	60835072	A	A	60835072	3	1	219	1	0	0	0	0	1	0	0	0	11332	956	33	2	79	2	OSBPL2	20	60835072	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	29228205	60835072	2190448	256	40393											
NKAIN4	128414	broad.mit.edu	37	chr20	61873937	61873937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggatggcttttcattgacatGgtagagaggaaatggatcaa	13	11	13	4	0	2	2	2	1	0	1	2	6	2	5	0	5	0	2	0	5	3	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr20:61873937G>A	uc002yek.2	-	6	661	c.571C>T	c.(571-573)CAT>TAT	p.H191Y		NM_152864	NP_690603	Q8IVV8	NKAI4_HUMAN	Na+/K+ transporting ATPase interacting 4	191						integral to membrane|plasma membrane					0	all_cancers(38;2.72e-09)					TCATTGACATGGTAGAGAGGA	0.453													65	198					0	0	0	0	A	61873937	A	A	61873937	3	1	219	1	0	0	0	0	1	0	0	0	10492	1348	47	4	63	4	NKAIN4	20	61873937	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1038865	61873937	1151583	257	40394											
SFRS15	57466	broad.mit.edu	37	chr21	33057747	33057747	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggtggagtgtgaggaggagGaatggatactggtggagtta	10	10	20	1	0	0	1	0	1	0	0	0	7	0	7	0	8	1	1	0	8	3	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr21:33057747G>A	uc002ypd.2	-	18	2686	c.2260C>T	c.(2260-2262)CCT>TCT	p.P754S	SFRS15_uc002ype.2_Missense_Mutation_p.P754S|SFRS15_uc010glu.2_Missense_Mutation_p.P739S|SFRS15_uc002ypf.1_Missense_Mutation_p.P428S	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	754						nucleus	nucleotide binding|RNA binding				0						TGAGGAGGAGGAATGGATACT	0.453													12	63					0	0	0	0	A	33057747	A	A	33057747	3	1	219	1	0	0	0	0	1	0	0	0	14236	1174	41	2	1195	2	SFRS15	21	33057747	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08		33057747	15072148	258	40395											
KRTAP10-6	386674	broad.mit.edu	37	chr21	46011649	46011649	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcagagcaggtgggcacAcagcacacaggcacgcagca	12	3	12	14	1	1	1	1	0	0	1	2	1	2	1	1	3	3	6	1	3	0	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr21:46011649A>C	uc002zfm.2	-	1	738	c.717T>G	c.(715-717)TGT>TGG	p.C239W	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198688	NP_941961	P60371	KR106_HUMAN	keratin associated protein 10-6	239	21.|29 X 5 AA repeats of C-C-X(3).					keratin filament					0						AGGTGGGCACACAGCACACAG	0.657													70	197					0	0	0	0	C	46011649	C	C	46011649	3	2	219	1	0	0	0	0	1	0	0	0	8552	157	6	5	384	5	KRTAP10-6	21	46011649	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	12953902	46011649	2118246	259	40396											
SLC19A1	6573	broad.mit.edu	37	chr21	46957703	46957703	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctgctcccgcgtgaagttCttgtcgggccccaggaggta	5	9	14	13	3	1	1	0	1	1	0	3	2	2	2	4	3	1	3	4	3	2	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr21:46957703C>T	uc002zhl.1	-	2	290	c.171G>A	c.(169-171)AAG>AAA	p.K57K	SLC19A1_uc010gpy.1_Silent_p.K57K|SLC19A1_uc002zhm.1_Silent_p.K57K|SLC19A1_uc010gpz.1_5'UTR	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	57	Extracellular (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GCGTGAAGTTCTTGTCGGGCC	0.687													7	7					0	0	0	0	T	46957703	T	T	46957703	2	4	219	1	0	0	0	0	0	0	0	1	14493	912	32	2		2	SLC19A1	21	46957703	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	946054	46957703	1172192	260	40397											
MCM3AP	8888	broad.mit.edu	37	chr21	47697544	47697544	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agggagagcacacatggcccGaggccctcggagccctcgga	9	3	15	14	3	0	1	0	0	0	1	2	5	0	3	3	5	2	1	3	5	0	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr21:47697544G>A	uc002zir.1	-	5	1791	c.1755C>T	c.(1753-1755)CTC>CTT	p.L585L		NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	585					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					CACATGGCCCGAGGCCCTCGG	0.552													12	111					0	0	0	0	A	47697544	A	A	47697544	2	1	219	1	0	0	0	0	0	0	0	1	9441	1045	37	1		1	MCM3AP	21	47697544	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	739841	47697544	432351	261	40398											
CECR1	51816	broad.mit.edu	37	chr22	17662734	17662734	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagagttcatggccagctgtTtgagggtcctcaggtcagcc	7	11	13	10	0	3	2	3	1	0	1	4	2	4	2	3	3	2	3	3	3	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr22:17662734T>A	uc002zmk.1	-	8	1630	c.1418A>T	c.(1417-1419)AAA>ATA	p.K473I	CECR1_uc010gqu.1_Missense_Mutation_p.K473I|CECR1_uc011agi.1_Missense_Mutation_p.K431I|CECR1_uc002zmj.1_Missense_Mutation_p.K232I	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	473					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				GGCCAGCTGTTTGAGGGTCCT	0.547													26	50					0	0	0	0	A	17662734	A	A	17662734	3	1	219	1	0	0	0	0	1	0	0	0	3220	1841	64	5	125	5	CECR1	22	17662734	Missense_Mutation	SNP	T	TCGA-CV-7095-01A-21D-2012-08		17662734	33641832	262	40399											
IGLL1	3543	broad.mit.edu	37	chr22	23915612	23915612	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtttggagggcgtggtcatCtccacgccctgggtgatggg	4	11	17	9	2	2	1	1	1	1	0	3	2	2	2	2	5	0	1	2	5	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr22:23915612C>G	uc002zxd.2	-	3	601	c.483G>C	c.(481-483)GAG>GAC	p.E161D	IGLL1_uc002zxe.2_3'UTR	NM_020070	NP_064455	P15814	IGLL1_HUMAN	immunoglobulin lambda-like polypeptide 1 isoform	161	C region (By similarity to lambda light- chain).|Ig-like C1-type.				immune response	extracellular region|membrane					0						GCGTGGTCATCTCCACGCCCT	0.582													3	154					0	0	0	0	G	23915612	G	G	23915612	3	3	219	1	0	0	0	0	1	0	0	0	7632	912	32	2	162	2	IGLL1	22	23915612	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	6252878	23915612	27388954	263	40400											
MGAT3	4248	broad.mit.edu	37	chr22	39883764	39883764	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacggccggaggagaagcctGagggggccaacggctcctcg	8	3	18	12	4	0	2	0	1	0	1	2	5	1	3	4	6	2	1	4	6	2	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr22:39883764G>A	uc003axv.3	+	2	651	c.412G>A	c.(412-414)GAG>AAG	p.E138K	MGAT3_uc010gxy.2_Missense_Mutation_p.E138K	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	138	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					GGAGAAGCCTGAGGGGGCCAA	0.741													4	11					0	0	0	0	A	39883764	A	A	39883764	3	1	219	1	0	0	0	0	1	0	0	0	9597	1291	45	2	414	2	MGAT3	22	39883764	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	15968152	39883764	11420802	264	40401											
MKL1	57591	broad.mit.edu	37	chr22	40815316	40815316	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcttgataggctcgaaggcGctcaatcagctcagttttgg	8	12	12	9	2	4	1	3	1	1	0	5	2	4	1	0	3	1	4	0	3	3	4			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr22:40815316G>A	uc003ayv.1	-	9	1333	c.1126C>T	c.(1126-1128)CGC>TGC	p.R376C	MKL1_uc003ayw.1_Missense_Mutation_p.R376C|MKL1_uc010gye.1_Missense_Mutation_p.R376C|MKL1_uc010gyf.1_Missense_Mutation_p.R326C	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	376	SAP.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCTCGAAGGCGCTCAATCAGC	0.607			T	RBM15	acute megakaryocytic leukemia								8	26					0	0	0	0	A	40815316	A	A	40815316	3	1	219	1	0	0	0	0	1	0	0	0	9654	1087	38	1	1685	1	MKL1	22	40815316	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	931552	40815316	10489250	265	40402											
EP300	2033	broad.mit.edu	37	chr22	41573028	41573028	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcagcataccaagggttgCaaacggaaaaccaatggcgg	14	5	13	9	2	0	0	0	0	0	0	0	1	0	1	2	4	6	4	2	4	6	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr22:41573028C>A	uc003azl.3	+	31	5708	c.5313C>A	c.(5311-5313)TGC>TGA	p.C1771*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1771	Binding region for E1A adenovirus.|TAZ-type 2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CCAAGGGTTGCAAACGGAAAA	0.567			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				9	38					3.86212e-05	4.17592e-05	1	0	A	41573028	A	A	41573028	4	1	219	1	0	0	0	0	0	1	0	0	5172	718	25	4	5435	4	EP300	22	41573028	Nonsense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	757712	41573028	9731538	266	40403											
XRCC6	2547	broad.mit.edu	37	chr22	42033722	42033722	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggacctcagggttcactttGaggaatccagcaagctagaa	13	8	11	9	0	2	2	2	1	0	1	3	4	3	4	2	3	2	3	2	3	4	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr22:42033722G>C	uc003bao.1	+	6	770	c.700G>C	c.(700-702)GAG>CAG	p.E234Q	XRCC6_uc003bap.1_Missense_Mutation_p.E193Q|XRCC6_uc011apc.1_Missense_Mutation_p.E184Q|XRCC6_uc003baq.1_Missense_Mutation_p.E234Q|XRCC6_uc003bar.1_Missense_Mutation_p.E234Q|XRCC6_uc003bas.1_Missense_Mutation_p.E184Q	NM_001469	NP_001460	P12956	XRCC6_HUMAN	ATP-dependent DNA helicase II, 70 kDa subunit	234					DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			skin(2)|ovary(1)|lung(1)|kidney(1)	5						GGTTCACTTTGAGGAATCCAG	0.537								Direct_reversal_of_damage|NHEJ					3	18					0	0	0	0	C	42033722	C	C	42033722	3	2	219	1	0	0	0	0	1	0	0	0	17525	1291	45	2	718	2	XRCC6	22	42033722	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	460694	42033722	9270844	267	40404											
TRMU	55687	broad.mit.edu	37	chr22	46751462	46751462	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gatgatggagtgccacttccGattccgccaccagatggcac	9	8	11	13	2	0	2	0	1	0	1	2	5	2	3	5	2	1	1	5	2	0	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr22:46751462G>C	uc003bhp.2	+	9	1359	c.995G>C	c.(994-996)CGA>CCA	p.R332P	TRMU_uc003bhq.2_Missense_Mutation_p.R114P|TRMU_uc003bhs.2_Missense_Mutation_p.R332P|TRMU_uc003bhr.2_Missense_Mutation_p.R218P|TRMU_uc003bht.2_Missense_Mutation_p.R185P|TRMU_uc003bhu.2_Missense_Mutation_p.R114P|TRMU_uc003bhv.2_Missense_Mutation_p.R185P	NM_018006	NP_060476	O75648	MTU1_HUMAN	tRNA 5-methylaminomethyl-2-thiouridylate	332						mitochondrion	ATP binding|sulfurtransferase activity|tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity|tRNA binding			ovary(1)	1		Ovarian(80;0.00965)|Breast(42;0.0194)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00449)|LUAD - Lung adenocarcinoma(64;0.248)		TGCCACTTCCGATTCCGCCAC	0.642											OREG0026654	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	33					0	0	0	0	C	46751462	C	C	46751462	3	2	219	1	0	0	0	0	1	0	0	0	16638	1058	37	3	1029	3	TRMU	22	46751462	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	4717740	46751462	4553104	268	40405											
TRMU	55687	broad.mit.edu	37	chr22	46752850	46752850	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagagctgggatggccactGagagccccagtgacagccca	10	4	14	13	0	0	3	0	2	0	2	0	5	0	4	4	2	3	2	4	2	0	0			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chr22:46752850G>A	uc003bhp.2	+	11	1577	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K	TRMU_uc003bhq.2_Missense_Mutation_p.E187K|TRMU_uc003bhs.2_Silent_p.*377*|TRMU_uc003bhr.2_Missense_Mutation_p.E291K|TRMU_uc003bht.2_Missense_Mutation_p.E258K|TRMU_uc003bhu.2_Missense_Mutation_p.E187K|TRMU_uc003bhv.2_Silent_p.*230*	NM_018006	NP_060476	O75648	MTU1_HUMAN	tRNA 5-methylaminomethyl-2-thiouridylate	405						mitochondrion	ATP binding|sulfurtransferase activity|tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity|tRNA binding			ovary(1)	1		Ovarian(80;0.00965)|Breast(42;0.0194)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00449)|LUAD - Lung adenocarcinoma(64;0.248)		GATGGCCACTGAGAGCCCCAG	0.632													15	39					0	0	0	0	A	46752850	A	A	46752850	3	1	219	1	0	0	0	0	1	0	0	0	16638	1291	45	2	1255	2	TRMU	22	46752850	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	1388	46752850	4551716	269	40406											
MXRA5	25878	broad.mit.edu	37	chrX	3241681	3241681	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagagcctttgcacctgggCgtctgcctcttttggatggc	6	12	12	11	1	2	1	0	0	2	1	2	2	2	2	3	3	3	1	3	3	1	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:3241681C>T	uc004crg.3	-	5	2202	c.2045G>A	c.(2044-2046)CGC>CAC	p.R682H		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	682						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGCACCTGGGCGTCTGCCTCT	0.532													27	71					0	0	0	0	T	3241681	T	T	3241681	3	4	219	1	0	0	0	0	1	0	0	0	10056	768	27	1	6453	1	MXRA5	23	3241681	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08		3241681	152028879	270	40407											
KAL1	3730	broad.mit.edu	37	chrX	8522000	8522000	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgtttatgtaccttctgtCttcttccagtagactttaac	9	18	5	9	0	3	1	0	0	3	1	4	1	4	1	2	0	2	3	2	0	5	9			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:8522000C>G	uc004csf.2	-	9	1497	c.1347G>C	c.(1345-1347)AAG>AAC	p.K449N		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor	449	Fibronectin type-III 3.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4						TACCTTCTGTCTTCTTCCAGT	0.413													5	21					0	0	0	0	G	8522000	G	G	8522000	3	3	219	1	0	0	0	0	1	0	0	0	8013	912	32	2	719	2	KAL1	23	8522000	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	5280319	8522000	146748560	271	40408											
DMD	1756	broad.mit.edu	37	chrX	31986549	31986549	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatactggcatctgtttttGaggattgctgaattatttct	9	18	9	5	0	2	2	0	2	2	0	2	4	2	3	0	2	2	3	0	2	4	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:31986549G>C	uc004dda.1	-	45	6765	c.6521C>G	c.(6520-6522)TCA>TGA	p.S2174*	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Nonsense_Mutation_p.S830*|DMD_uc004dcx.2_Nonsense_Mutation_p.S833*|DMD_uc004dcz.2_Nonsense_Mutation_p.S2051*|DMD_uc004dcy.1_Nonsense_Mutation_p.S2170*|DMD_uc004ddb.1_Nonsense_Mutation_p.S2166*|DMD_uc010ngo.1_Nonsense_Mutation_p.S83*|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2174	Spectrin 15.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATCTGTTTTTGAGGATTGCTG	0.458													23	72					0	0	0	0	C	31986549	C	C	31986549	4	2	219	1	0	0	0	0	0	1	0	0	4602	1294	45	2	4824	2	DMD	23	31986549	Nonsense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	23464549	31986549	123284011	272	40409											
CFP	5199	broad.mit.edu	37	chrX	47486681	47486681	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgtggggtccaccgtggcAggaggctgagcagggggtcc	5	7	19	10	2	0	1	0	1	0	0	3	2	2	2	3	7	1	3	3	7	0	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:47486681A>G	uc004dig.3	-	5	751	c.625T>C	c.(625-627)TGC>CGC	p.C209R	CFP_uc004dih.2_Missense_Mutation_p.C209R|CFP_uc004dii.1_Missense_Mutation_p.C145R|CFP_uc010nhu.2_Missense_Mutation_p.C209R	NM_001145252	NP_001138724	P27918	PROP_HUMAN	complement factor properdin precursor	209	TSP type-1 3.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3						CCACCGTGGCAGGAGGCTGAG	0.667													3	14					0	0	0	0	G	47486681	G	G	47486681	3	3	219	1	0	0	0	0	1	0	0	0	3308	188	7	5	804	5	CFP	23	47486681	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	15500132	47486681	107783879	273	40410											
ZNF630	57232	broad.mit.edu	37	chrX	47918145	47918145	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctctccagtatgacctctCtgatgtagaatgagatgtga	10	14	9	8	0	2	5	0	4	2	2	5	6	3	5	2	0	0	2	2	0	3	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:47918145C>G	uc004div.3	-	5	1938	c.1686G>C	c.(1684-1686)CAG>CAC	p.Q562H	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.Q438H	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	562	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						TATGACCTCTCTGATGTAGAA	0.448													10	11					0	0	0	0	G	47918145	G	G	47918145	3	3	219	1	0	0	0	0	1	0	0	0	18121	912	32	2	291	2	ZNF630	23	47918145	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	431464	47918145	107352415	274	40411											
WAS	7454	broad.mit.edu	37	chrX	48542320	48542320	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagaacataccctccaccctCctccaggaccacgagaacca	13	4	5	19	1	0	2	0	0	0	2	3	4	3	3	7	1	3	0	7	1	3	1			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:48542320C>G	uc004dkm.3	+	1	135	c.78C>G	c.(76-78)CTC>CTG	p.L26L		NM_000377	NP_000368	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome protein	26					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			ovary(1)	1		all_lung(315;1.27e-10)				CCTCCACCCTCCTCCAGGACC	0.607			Mis|N|F|S			lymphoma			Wiskott-Aldrich_syndrome				16	50					0	0	0	0	G	48542320	G	G	48542320	2	3	219	1	0	0	0	0	0	0	0	1	17319	842	30	2		2	WAS	23	48542320	Silent	SNP	C	TCGA-CV-7095-01A-21D-2012-08	624175	48542320	106728240	275	40412											
BRWD3	254065	broad.mit.edu	37	chrX	79980467	79980467	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgaattttggtcccccggtCaaggtcccaaataaaaatgt	12	10	8	11	2	1	0	1	0	0	0	3	1	3	0	4	3	0	0	4	3	6	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:79980467C>T	uc004edt.2	-	15	1749	c.1486G>A	c.(1486-1488)GAC>AAC	p.D496N	BRWD3_uc004edo.2_Missense_Mutation_p.D92N|BRWD3_uc004edp.2_Missense_Mutation_p.D325N|BRWD3_uc004edq.2_Missense_Mutation_p.D92N|BRWD3_uc010nmj.1_Missense_Mutation_p.D92N|BRWD3_uc004edr.2_Missense_Mutation_p.D166N|BRWD3_uc004eds.2_Missense_Mutation_p.D92N|BRWD3_uc004edu.2_Missense_Mutation_p.D166N|BRWD3_uc004edv.2_Missense_Mutation_p.D92N|BRWD3_uc004edw.2_Missense_Mutation_p.D92N|BRWD3_uc004edx.2_Missense_Mutation_p.D92N|BRWD3_uc004edy.2_Missense_Mutation_p.D92N|BRWD3_uc004edz.2_Missense_Mutation_p.D166N|BRWD3_uc004eea.2_Missense_Mutation_p.D166N|BRWD3_uc004eeb.2_Missense_Mutation_p.D92N	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	496	WD 8.									ovary(4)	4						GTCCCCCGGTCAAGGTCCCAA	0.388													8	14					0	0	0	0	T	79980467	T	T	79980467	3	4	219	1	0	0	0	0	1	0	0	0	1531	826	29	2	4030	2	BRWD3	23	79980467	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	31438147	79980467	75290093	276	40413											
ZNF711	7552	broad.mit.edu	37	chrX	84525039	84525039	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggactcagcattagaaagcaGaagtagtacagcagcacagt	16	6	11	8	0	1	2	1	0	0	2	1	3	1	3	0	1	5	6	0	1	5	3			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:84525039G>C	uc004eeo.2	+	8	1342	c.995G>C	c.(994-996)AGA>ACA	p.R332T	ZNF711_uc004eep.2_Missense_Mutation_p.R332T|ZNF711_uc004eeq.2_Missense_Mutation_p.R378T|ZNF711_uc011mqy.1_5'UTR	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	332					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						TTAGAAAGCAGAAGTAGTACA	0.333													8	30					0	0	0	0	C	84525039	C	C	84525039	3	2	219	1	0	0	0	0	1	0	0	0	18183	942	33	2	1017	2	ZNF711	23	84525039	Missense_Mutation	SNP	G	TCGA-CV-7095-01A-21D-2012-08	4544572	84525039	70745521	277	40414											
ZNF449	203523	broad.mit.edu	37	chrX	134494925	134494925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagaagccatacaagtgtaCtcattgttctaaaagcttca	14	11	8	8	0	3	1	2	0	1	1	3	2	3	1	1	1	4	3	1	1	6	6			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:134494925C>T	uc004eys.2	+	5	1646	c.1481C>T	c.(1480-1482)ACT>ATT	p.T494I	ZNF449_uc004eyt.2_Missense_Mutation_p.T374I|ZNF449_uc004eyu.2_Missense_Mutation_p.T300I	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	494	C2H2-type 7.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TACAAGTGTACTCATTGTTCT	0.393													92	135					0	0	0	0	T	134494925	T	T	134494925	3	4	219	1	0	0	0	0	1	0	0	0	17987	565	20	4	1495	4	ZNF449	23	134494925	Missense_Mutation	SNP	C	TCGA-CV-7095-01A-21D-2012-08	49969886	134494925	20775635	278	40415											
GPR112	139378	broad.mit.edu	37	chrX	135431707	135431707	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctatgtcaggaattcttcctAaccatgggctttctgagaac	10	13	8	10	0	3	1	1	1	2	1	4	3	4	2	2	2	2	1	2	2	4	5			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:135431707A>T	uc004ezu.1	+	6	6133	c.5842A>T	c.(5842-5844)AAC>TAC	p.N1948Y	GPR112_uc010nsb.1_Missense_Mutation_p.N1743Y|GPR112_uc010nsc.1_Missense_Mutation_p.N1715Y	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1948	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AATTCTTCCTAACCATGGGCT	0.418													6	147					0	0	0	0	T	135431707	T	T	135431707	3	4	219	1	0	0	0	0	1	0	0	0	6667	362	13	5	5852	5	GPR112	23	135431707	Missense_Mutation	SNP	A	TCGA-CV-7095-01A-21D-2012-08	936782	135431707	19838853	279	40416											
MAGEC1	9947	broad.mit.edu	37	chrX	140995473	140995473	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttccccagagtttccctgaGagtcctcagagtcctcctga	7	11	8	15	0	1	4	1	2	0	3	6	5	6	4	6	0	0	1	6	0	0	2			TCGA-CV-7095-01A-21D-2012-08	TCGA-CV-7095-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4aba107-a048-46e5-b0aa-901f076b6f61	8b5bfd48-6872-43dc-8c75-4c56f159eed4	g.chrX:140995473G>A	uc004fbt.2	+	4	2569	c.2283G>A	c.(2281-2283)GAG>GAA	p.E761E	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	761							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GTTTCCCTGAGAGTCCTCAGA	0.542										HNSCC(15;0.026)			82	238					0	0	0	0	A	140995473	A	A	140995473	2	1	219	1	0	0	0	0	0	0	0	1	9233	933	33	2		2	MAGEC1	23	140995473	Silent	SNP	G	TCGA-CV-7095-01A-21D-2012-08	5563766	140995473	14275087	280	40417											
KIF17	57576	broad.mit.edu	37	chr1	21013938	21013938	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgtcctggccacggtggaGgagagtctggccagcttggc	5	9	16	11	1	2	1	0	0	2	1	3	3	3	2	3	6	1	1	3	6	0	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:21013938G>A	uc001bdr.3	-	8	1999	c.1881C>T	c.(1879-1881)TCC>TCT	p.S627S	KIF17_uc001bdp.3_5'Flank|KIF17_uc001bdq.3_5'Flank|KIF17_uc009vpx.2_Intron|KIF17_uc001bds.3_Silent_p.S627S	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	627					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CCACGGTGGAGGAGAGTCTGG	0.637													34	72					0	0	0	0	A	21013938	A	A	21013938	2	1	220	1	0	0	0	0	0	0	0	1	8318	987	35	4		4	KIF17	1	21013938	Silent	SNP	G	TCGA-CV-7097-01A-11D-2012-08		21013938	228236683	1	40418											
BMP8B	656	broad.mit.edu	37	chr1	40228830	40228830	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgggaaggagcactccccCtcacagtaataggccgagta	12	6	12	11	1	1	0	1	0	0	0	2	3	2	2	3	3	1	3	3	3	4	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:40228830C>A	uc001cdz.1	-	6	1369	c.993G>T	c.(991-993)GAG>GAT	p.E331D	PPIE_uc001cdv.2_Intron|PPIE_uc001cdw.2_Intron	NM_001720	NP_001711	P34820	BMP8B_HUMAN	bone morphogenetic protein 8B preproprotein	331					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity				0	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AGCACTCCCCCTCACAGTAAT	0.632													6	83					0.00198382	0.00477025	1	0	A	40228830	A	A	40228830	3	1	220	1	0	0	0	0	1	0	0	0	1470	680	24	4	223	4	BMP8B	1	40228830	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	19214892	40228830	209021791	2	40419											
C1orf168	199920	broad.mit.edu	37	chr1	57257788	57257788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggggctgcttgccgggCtcctctcaggaggtgggttt	3	10	18	10	1	1	0	1	0	1	0	3	1	2	1	2	7	2	5	2	7	0	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:57257788C>T	uc001cym.3	-	2	1104	c.698G>A	c.(697-699)AGC>AAC	p.S233N	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Missense_Mutation_p.S233N	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	233										ovary(3)|skin(2)	5						GCTTGCCGGGCTCCTCTCAGG	0.532													38	80					0	0	0	0	T	57257788	T	T	57257788	3	4	220	1	0	0	0	0	1	0	0	0	2021	797	28	4	1564	4	C1orf168	1	57257788	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	17028958	57257788	191992833	3	40420											
SERBP1	26135	broad.mit.edu	37	chr1	67889975	67889975	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagtcactgtaattataagaTatttgtttctgaatgtattt	13	19	6	3	0	2	2	1	1	1	1	2	2	2	2	0	0	0	3	0	0	7	8			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:67889975T>C	uc001ddv.2	-	5	866	c.726A>G	c.(724-726)ATA>ATG	p.I242M	SERBP1_uc001ddx.2_Missense_Mutation_p.I236M|SERBP1_uc001ddy.2_Intron|SERBP1_uc001ddw.2_Intron	NM_001018067	NP_001018077	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1 isoform 1	242					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			skin(1)	1						AATTATAAGATATTTGTTTCT	0.363													21	46					0	0	0	0	C	67889975	C	C	67889975	3	2	220	1	0	0	0	0	1	0	0	0	14140	1396	49	5	516	5	SERBP1	1	67889975	Missense_Mutation	SNP	T	TCGA-CV-7097-01A-11D-2012-08	10632187	67889975	181360646	4	40421											
AMY2B	280	broad.mit.edu	37	chr1	104115755	104115755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gagtgcaggaacaagcagtaCctgtggaagttacttcaacc	13	8	11	9	0	1	0	1	0	0	0	1	3	1	2	2	2	6	4	2	2	6	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:104115755C>T	uc001duq.2	+	5	1002	c.386C>T	c.(385-387)ACC>ATC	p.T129I	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.T129I|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	129					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		ACAAGCAGTACCTGTGGAAGT	0.403													117	411					0	0	0	0	T	104115755	T	T	104115755	3	4	220	1	0	0	0	0	1	0	0	0	595	507	18	4	396	4	AMY2B	1	104115755	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	36225780	104115755	145134866	5	40422											
HSD3B1	3283	broad.mit.edu	37	chr1	120050217	120050217	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtcttggacaaggccttcGgaccagaattgagagaggaa	12	7	15	7	1	1	3	0	1	1	2	2	7	1	6	2	5	0	0	2	5	3	3	rs141328314		TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:120050217G>A	uc001ehv.1	+	2	263	c.118G>A	c.(118-120)GGA>AGA	p.G40R	HSD3B1_uc001ehw.2_Missense_Mutation_p.G42R	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	40					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	CAAGGCCTTCGGACCAGAATT	0.507													23	71					0	0	0	0	A	120050217	A	A	120050217	3	1	220	1	0	0	0	0	1	0	0	0	7429	1117	39	1	120	1	HSD3B1	1	120050217	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	15934462	120050217	129200404	6	40423											
ARNT	405	broad.mit.edu	37	chr1	150795676	150795676	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtataatacatacttcacaTtggtgttggtacagatgatg	12	15	9	5	0	1	2	1	1	0	1	1	2	1	2	0	2	3	3	0	2	5	8			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:150795676T>C	uc001evr.1	-	14	1531	c.1388A>G	c.(1387-1389)AAT>AGT	p.N463S	ARNT_uc001evs.1_Missense_Mutation_p.N448S|ARNT_uc009wmb.1_Missense_Mutation_p.N449S|ARNT_uc009wmc.1_Missense_Mutation_p.N463S|ARNT_uc009wmd.1_Missense_Mutation_p.N448S|ARNT_uc009wme.1_Intron|ARNT_uc010pcl.1_Missense_Mutation_p.N447S	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	463	PAC.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			ATACTTCACATTGGTGTTGGT	0.279			T	ETV6	AML								4	52					0	0	0	0	C	150795676	C	C	150795676	3	2	220	1	0	0	0	0	1	0	0	0	967	1493	52	5	1017	5	ARNT	1	150795676	Missense_Mutation	SNP	T	TCGA-CV-7097-01A-11D-2012-08	30745459	150795676	98454945	7	40424											
FLG	2312	broad.mit.edu	37	chr1	152279921	152279921	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgtccagatctatctaccaAttgctcgtagtgggatccct	8	13	9	11	1	2	1	0	0	2	1	5	2	4	2	3	1	2	2	3	1	4	4			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:152279921A>G	uc001ezu.1	-	3	7477	c.7441T>C	c.(7441-7443)TTG>CTG	p.L2481L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2481	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTATCTACCAATTGCTCGTAG	0.567									Ichthyosis				5	534					0	0	0	0	G	152279921	G	G	152279921	2	3	220	1	0	0	0	0	0	0	0	1	5954	98	4	5		5	FLG	1	152279921	Silent	SNP	A	TCGA-CV-7097-01A-11D-2012-08	1484245	152279921	96970700	8	40425											
PEAR1	375033	broad.mit.edu	37	chr1	156874633	156874633	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgggagggcccccatacttgCccccagcccacgtgagtgct	6	7	12	16	1	0	1	0	1	0	0	0	2	0	2	5	2	4	1	5	2	1	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:156874633C>T	uc001fqj.1	+	3	311	c.195C>T	c.(193-195)TGC>TGT	p.C65C	PEAR1_uc009wsl.1_5'Flank|PEAR1_uc001fqk.1_5'Flank	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	65	EMI.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCCATACTTGCCCCCAGCCCA	0.657													12	54					0	0	0	0	T	156874633	T	T	156874633	2	4	220	1	0	0	0	0	0	0	0	1	11766	747	26	4		4	PEAR1	1	156874633	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08	4594712	156874633	92375988	9	40426											
LGR6	59352	broad.mit.edu	37	chr1	202249913	202249913	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttccttcccgtgcaggcatTtgcataacaaccgcatccag	9	11	7	14	2	0	0	0	0	0	0	3	0	3	0	4	1	4	4	4	1	2	4			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:202249913T>G	uc001gxu.2	+	6	649	c.649T>G	c.(649-651)TTG>GTG	p.L217V	LGR6_uc001gxv.2_Missense_Mutation_p.L165V|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Intron|LGR6_uc009xac.1_RNA	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	217	LRR 6.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						GTGCAGGCATTTGCATAACAA	0.562													30	64					0	0	0	0	G	202249913	G	G	202249913	3	3	220	1	0	0	0	0	1	0	0	0	8799	1838	64	5	818	5	LGR6	1	202249913	Missense_Mutation	SNP	T	TCGA-CV-7097-01A-11D-2012-08	45375280	202249913	47000708	10	40427											
TRAF5	7188	broad.mit.edu	37	chr1	211534067	211534067	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgaggaaaacttgtgtccTgaatacccagtattttgtcc	11	13	8	9	0	0	2	0	2	0	0	2	3	2	3	3	1	2	1	3	1	5	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:211534067T>C	uc001hih.2	+	6	627	c.567T>C	c.(565-567)CCT>CCC	p.P189P	TRAF5_uc001hii.2_Silent_p.P189P|TRAF5_uc010psx.1_Silent_p.P200P|TRAF5_uc010psy.1_Intron|TRAF5_uc001hij.2_Silent_p.P189P	NM_004619	NP_004610	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	189	TRAF-type 2.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(2)|ovary(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		ACTTGTGTCCTGAATACCCAG	0.373													3	40					0	0	0	0	C	211534067	C	C	211534067	2	2	220	1	0	0	0	0	0	0	0	1	16511	1567	55	5		5	TRAF5	1	211534067	Silent	SNP	T	TCGA-CV-7097-01A-11D-2012-08	9284154	211534067	37716554	11	40428											
ZNF124	7678	broad.mit.edu	37	chr1	247320151	247320151	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tacatggatagggttcttcaCcagcatgagcctttatatgt	10	14	9	8	0	2	1	1	1	1	0	2	2	2	2	2	2	3	2	2	2	4	7			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr1:247320151C>G	uc001ick.2	-	4	912	c.773G>C	c.(772-774)GGT>GCT	p.G258A	ZNF124_uc001ici.2_Intron|ZNF124_uc001icj.1_Missense_Mutation_p.G196A	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			GGGTTCTTCACCAGCATGAGC	0.438													32	68					0	0	0	0	G	247320151	G	G	247320151	3	3	220	1	0	0	0	0	1	0	0	0	17787	507	18	4	286	4	ZNF124	1	247320151	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	35786084	247320151	1930470	12	40429											
NCOA1	8648	broad.mit.edu	37	chr2	24929972	24929972	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taacatctttacagggtatgAatgaaggacccaataactcc	15	10	7	9	0	1	2	0	2	1	0	2	3	2	3	2	2	3	1	2	2	7	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr2:24929972A>G	uc002rfk.2	+	11	1891	c.1633A>G	c.(1633-1635)AAT>GAT	p.N545D	NCOA1_uc010eye.2_Missense_Mutation_p.N545D|NCOA1_uc002rfi.2_Missense_Mutation_p.N394D|NCOA1_uc002rfj.2_Missense_Mutation_p.N545D|NCOA1_uc002rfl.2_Missense_Mutation_p.N545D	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	545	Interaction with STAT3.|Ser-rich.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAGGGTATGAATGAAGGACC	0.423			T	PAX3	alveolar rhadomyosarcoma								9	38					0	0	0	0	G	24929972	G	G	24929972	3	3	220	1	0	0	0	0	1	0	0	0	10282	246	9	5	1667	5	NCOA1	2	24929972	Missense_Mutation	SNP	A	TCGA-CV-7097-01A-11D-2012-08		24929972	218269401	13	40430											
DNAH6	1768	broad.mit.edu	37	chr2	84784958	84784958	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgctttcaccagcccttatAttaacaacaaacttgaagga	15	11	5	10	0	1	1	1	1	0	0	1	2	1	2	2	1	5	1	2	1	6	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr2:84784958A>G	uc010fgb.2	+	11	1839	c.1702A>G	c.(1702-1704)ATT>GTT	p.I568V	DNAH6_uc002soo.2_Missense_Mutation_p.I147V|DNAH6_uc002sop.2_Missense_Mutation_p.I147V	NM_001370	NP_001361	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy polypeptide 6	568	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1						CAGCCCTTATATTAACAACAA	0.368													21	79					0	0	0	0	G	84784958	G	G	84784958	3	3	220	1	0	0	0	0	1	0	0	0	4627	449	16	5	1740	5	DNAH6	2	84784958	Missense_Mutation	SNP	A	TCGA-CV-7097-01A-11D-2012-08	59854986	84784958	158414415	14	40431											
FIGN	55137	broad.mit.edu	37	chr2	164466120	164466120	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatatcaagctccttttgaGatatgctaggctgaatcttg	11	14	8	8	0	2	2	1	2	1	1	3	3	3	2	1	1	2	3	1	1	5	6			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr2:164466120G>A	uc002uck.1	-	3	2533	c.2222C>T	c.(2221-2223)TCT>TTT	p.S741F		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	741						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CTCCTTTTGAGATATGCTAGG	0.393													42	64					0	0	0	0	A	164466120	A	A	164466120	3	1	220	1	0	0	0	0	1	0	0	0	5923	942	33	2	61	2	FIGN	2	164466120	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	79681162	164466120	78733253	15	40432											
TTN	7273	broad.mit.edu	37	chr2	179595727	179595727	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaagtatattctccactatCtttcttttctgtagaaataa	13	17	4	7	0	4	1	0	0	4	1	5	2	4	1	1	0	0	2	1	0	7	9			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr2:179595727C>T	uc010zfg.1	-	57	14157	c.13933G>A	c.(13933-13935)GAT>AAT	p.D4645N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D1306N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5572							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCCACTATCTTTCTTTTCT	0.378													87	179					0	0	0	0	T	179595727	T	T	179595727	3	4	220	1	0	0	0	0	1	0	0	0	16803	913	32	2	87076	2	TTN	2	179595727	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	15129607	179595727	63603646	16	40433											
HDAC4	9759	broad.mit.edu	37	chr2	239988450	239988450	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caaggcagaaacacatgcttCcgaggcgtcgcaaatggcgg	12	5	13	11	4	0	1	0	0	0	1	2	2	1	1	1	4	2	3	1	4	3	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr2:239988450C>A	uc002vyk.3	-	24	3748	c.2956G>T	c.(2956-2958)GAA>TAA	p.E986*	HDAC4_uc010fyy.2_Nonsense_Mutation_p.E943*	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	986	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		ACACATGCTTCCGAGGCGTCG	0.642													32	45					6.00712e-18	1.59012e-17	1	0	A	239988450	A	A	239988450	4	1	220	1	0	0	0	0	0	1	0	0	7048	864	30	2	314	2	HDAC4	2	239988450	Nonsense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	60392723	239988450	3210923	17	40434											
SLC22A14	9389	broad.mit.edu	37	chr3	38347632	38347632	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtctctggagatgctgttaCgcagattgagggctgtccac	7	11	14	9	1	1	3	0	1	1	2	3	4	2	3	1	3	2	4	1	3	1	2	rs142344011	byFrequency	TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr3:38347632C>T	uc010hhc.1	+	2	157	c.115C>T	c.(115-117)CGC>TGC	p.R39C	SLC22A14_uc003cia.2_Missense_Mutation_p.R39C|SLC22A14_uc003cib.2_Missense_Mutation_p.R39C|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	39	Cytoplasmic (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		GATGCTGTTACGCAGATTGAG	0.537													10	80					0	0	0	0	T	38347632	T	T	38347632	3	4	220	1	0	0	0	0	1	0	0	0	14510	536	19	1	117	1	SLC22A14	3	38347632	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08		38347632	159674798	18	40435											
XCR1	2829	broad.mit.edu	37	chr3	46062445	46062445	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccacaggcccctcagtagAaggaggcgccctcataggcg	9	4	13	15	3	2	1	2	0	0	1	2	2	2	2	4	4	0	1	4	4	3	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr3:46062445A>G	uc003cpe.2	-	3	1219	c.995T>C	c.(994-996)TTC>TCC	p.F332S	uc003cpd.1_5'Flank|XCR1_uc003cpf.2_Missense_Mutation_p.F332S	NM_005283	NP_005274	P46094	XCR1_HUMAN	XC chemokine receptor 1	332	Cytoplasmic (Potential).				chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		CCCTCAGTAGAAGGAGGCGCC	0.642													12	5					0	0	0	0	G	46062445	G	G	46062445	3	3	220	1	0	0	0	0	1	0	0	0	17493	246	9	5	10	5	XCR1	3	46062445	Missense_Mutation	SNP	A	TCGA-CV-7097-01A-11D-2012-08	7714813	46062445	151959985	19	40436											
HTR1F	3355	broad.mit.edu	37	chr3	88040372	88040372	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttttatctctatgcctcCtctattctggaggcaccaag	7	16	7	11	0	3	0	0	0	3	0	5	1	4	1	3	2	1	2	3	2	4	6			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr3:88040372C>T	uc003dqr.2	+	2	631	c.473C>T	c.(472-474)CCT>CTT	p.P158L		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	158	Helical; Name=4; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	TCTATGCCTCCTCTATTCTGG	0.408													23	23					0	0	0	0	T	88040372	T	T	88040372	3	4	220	1	0	0	0	0	1	0	0	0	7479	681	24	4	475	4	HTR1F	3	88040372	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	41977927	88040372	109982058	20	40437											
DPPA2	151871	broad.mit.edu	37	chr3	109028057	109028057	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagttgttgacaccagtccCgcaaagtgtcccgacacacc	10	7	9	15	3	0	1	0	1	0	0	2	3	2	1	4	0	0	3	4	0	1	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr3:109028057C>T	uc003dxo.2	-	4	549	c.302G>A	c.(301-303)CGG>CAG	p.R101Q		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	101	SAP.					nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						ACACCAGTCCCGCAAAGTGTC	0.453													42	182					0	0	0	0	T	109028057	T	T	109028057	3	4	220	1	0	0	0	0	1	0	0	0	4756	652	23	1	614	1	DPPA2	3	109028057	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	20987685	109028057	88994373	21	40438											
BTLA	151888	broad.mit.edu	37	chr3	112198458	112198458	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaacttgtttgtctatcttCaagttttacacatgttgttc	8	19	5	9	0	3	0	1	0	2	0	4	0	3	0	1	0	2	4	1	0	4	8			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr3:112198458C>A	uc003dza.3	-	2	450	c.247G>T	c.(247-249)GAA>TAA	p.E83*	BTLA_uc003dzb.3_Nonsense_Mutation_p.E83*	NM_181780	NP_861445	Q7Z6A9	BTLA_HUMAN	B and T lymphocyte associated isoform 1	83	Ig-like V-type.|Extracellular (Potential).				T cell costimulation		receptor activity				0		Acute lymphoblastic leukemia(4;1.34e-07)|all_hematologic(4;0.000361)				TGTCTATCTTCAAGTTTTACA	0.408													21	96					1.50039e-11	3.87396e-11	1	0	A	112198458	A	A	112198458	4	1	220	1	0	0	0	0	0	1	0	0	1563	835	29	2	638	2	BTLA	3	112198458	Nonsense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	3170401	112198458	85823972	22	40439											
STXBP5L	9515	broad.mit.edu	37	chr3	120998716	120998716	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacagaagacagtactgttaAgcatggggaccattgaccta	14	9	10	8	0	0	3	0	1	0	2	0	4	0	4	2	2	3	3	2	2	5	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr3:120998716A>G	uc003eec.3	+	19	2163	c.2023A>G	c.(2023-2025)AGC>GGC	p.S675G	STXBP5L_uc011bji.1_Missense_Mutation_p.S675G	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	675	WD 10.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AGTACTGTTAAGCATGGGGAC	0.398													27	46					0	0	0	0	G	120998716	G	G	120998716	3	3	220	1	0	0	0	0	1	0	0	0	15423	72	3	5	2093	5	STXBP5L	3	120998716	Missense_Mutation	SNP	A	TCGA-CV-7097-01A-11D-2012-08	8800258	120998716	77023714	23	40440											
PLXND1	23129	broad.mit.edu	37	chr3	129324754	129324754	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaggtcgccgcgcgtgtcCagggagcggatggcgatctc	5	6	17	13	6	1	0	0	0	1	0	4	3	2	2	3	4	1	0	3	4	0	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr3:129324754C>T	uc003emx.2	-	1	829	c.729G>A	c.(727-729)CTG>CTA	p.L243L		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	243	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CGCGCGTGTCCAGGGAGCGGA	0.647													12	18					0	0	0	0	T	129324754	T	T	129324754	2	4	220	1	0	0	0	0	0	0	0	1	12182	581	21	4		4	PLXND1	3	129324754	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08	8326038	129324754	68697676	24	40441											
CPNE4	131034	broad.mit.edu	37	chr3	131254048	131254048	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgtggggagttcatggtgcTagtgttctggaagattcata	8	14	15	4	0	3	1	2	0	1	1	3	3	3	3	0	4	1	3	0	4	3	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr3:131254048T>C	uc003eok.2	-	16	2100	c.1665A>G	c.(1663-1665)CTA>CTG	p.L555L	CPNE4_uc011blq.1_Silent_p.L573L|CPNE4_uc003eol.2_Silent_p.L573L|CPNE4_uc003eom.2_Silent_p.L555L|CPNE4_uc003eoj.2_Silent_p.L106L	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	555										upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTCATGGTGCTAGTGTTCTGG	0.368													16	47					0	0	0	0	C	131254048	C	C	131254048	2	2	220	1	0	0	0	0	0	0	0	1	3829	1509	53	5		5	CPNE4	3	131254048	Silent	SNP	T	TCGA-CV-7097-01A-11D-2012-08	1929294	131254048	66768382	25	40442											
PLD1	5337	broad.mit.edu	37	chr3	171379875	171379875	+	Frame_Shift_Del	DEL	T	-	-																															tatagatatagtgcctgctgTtctctatcacatggacgtaa																										TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr3:171379875delT	uc003fhs.2	-	20	2431	c.2315delA	c.(2314-2316)AACfs	p.N772fs	PLD1_uc003fht.2_Frame_Shift_Del_p.N734fs|PLD1_uc003fhu.3_Frame_Shift_Del_p.N66fs|PLD1_uc003fhv.1_Frame_Shift_Del_p.N97fs	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	772	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GTGCCTGCTGTTCTCTATCAC	0.458													---	---	---								-	171379875	-	-	171379875	7	5	220	1	0	1	0	1	0	0	0	0	12100	1725	60	0	941	0	PLD1	3	171379875	Frame_Shift_Del	DEL	T	TCGA-CV-7097-01A-11D-2012-08	40125827	171379875	26642555	26	40443											
PHF17	79960	broad.mit.edu	37	chr4	129776938	129776938	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggtccacgttagctgtgctCtgtggatccctgaggtacgt	5	12	14	10	2	1	1	0	1	1	0	3	2	3	2	2	3	3	4	2	3	2	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr4:129776938C>T	uc003igk.2	+	7	1130	c.850C>T	c.(850-852)CTG>TTG	p.L284L	PHF17_uc003igj.2_Silent_p.L284L|PHF17_uc003igl.2_Silent_p.L272L|PHF17_uc011cgy.1_Silent_p.L284L|PHF17_uc003igm.2_Silent_p.L284L	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	284					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						TAGCTGTGCTCTGTGGATCCC	0.363													8	32					0	0	0	0	T	129776938	T	T	129776938	2	4	220	1	0	0	0	0	0	0	0	1	11883	912	32	2		2	PHF17	4	129776938	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08		129776938	61377338	27	40444											
NAA15	80155	broad.mit.edu	37	chr4	140265372	140265372	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtggattatgaatatagTgaactactcttatatcagaa	16	13	8	4	0	2	3	1	2	1	1	2	4	2	4	0	2	2	0	0	2	10	6			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr4:140265372T>C	uc003ihu.1	+	6	826	c.570T>C	c.(568-570)AGT>AGC	p.S190S		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	190					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						ATGAATATAGTGAACTACTCT	0.333													3	43					0	0	0	0	C	140265372	C	C	140265372	2	2	220	1	0	0	0	0	0	0	0	1	10171	1693	59	5		5	NAA15	4	140265372	Silent	SNP	T	TCGA-CV-7097-01A-11D-2012-08	10488434	140265372	50888904	28	40445											
SMAD1	4086	broad.mit.edu	37	chr4	146435852	146435852	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcgatgaagaagaaaaatgGgcagagaaagctgttgatgc	16	6	15	4	1	0	5	0	2	0	3	0	7	0	5	0	2	2	3	0	2	5	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr4:146435852G>A	uc003ikc.2	+	2	503	c.87G>A	c.(85-87)TGG>TGA	p.W29*	SMAD1_uc003ikd.2_Nonsense_Mutation_p.W29*|SMAD1_uc010iov.2_Nonsense_Mutation_p.W29*|SMAD1_uc011cic.1_Nonsense_Mutation_p.W29*	NM_005900	NP_005891	Q15797	SMAD1_HUMAN	Sma- and Mad-related protein 1	29	MH1.				BMP signaling pathway|embryonic pattern specification|primary miRNA processing|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|nuclear inner membrane	co-SMAD binding|I-SMAD binding|identical protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			ovary(1)	1	all_hematologic(180;0.151)					AAGAAAAATGGGCAGAGAAAG	0.443													4	49					0	0	0	0	A	146435852	A	A	146435852	4	1	220	1	0	0	0	0	0	1	0	0	14821	1241	43	4	89	4	SMAD1	4	146435852	Nonsense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	6170480	146435852	44718424	29	40446											
GUCY1A3	2982	broad.mit.edu	37	chr4	156634710	156634710	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacactcgcttcgaccagcAgtgtggagagctggatgtct	8	10	13	10	2	1	1	0	0	1	1	3	4	1	2	1	2	3	4	1	2	1	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr4:156634710A>T	uc003iov.2	+	8	2083	c.1547A>T	c.(1546-1548)CAG>CTG	p.Q516L	GUCY1A3_uc010iqc.2_Missense_Mutation_p.Q516L|GUCY1A3_uc003iow.2_Missense_Mutation_p.Q516L|GUCY1A3_uc010iqd.2_Missense_Mutation_p.Q515L|GUCY1A3_uc003iox.2_Missense_Mutation_p.Q516L|GUCY1A3_uc003ioz.2_Missense_Mutation_p.Q281L|GUCY1A3_uc003ioy.2_Missense_Mutation_p.Q516L|GUCY1A3_uc010iqe.2_Missense_Mutation_p.Q281L|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.Q516L	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	516	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TTCGACCAGCAGTGTGGAGAG	0.522													6	37					0	0	0	0	T	156634710	T	T	156634710	3	4	220	1	0	0	0	0	1	0	0	0	6933	188	7	5	1580	5	GUCY1A3	4	156634710	Missense_Mutation	SNP	A	TCGA-CV-7097-01A-11D-2012-08	10198858	156634710	34519566	30	40447											
CBR4	84869	broad.mit.edu	37	chr4	169927998	169928000	+	Missense_Mutation	TNP	TGA	CTT	CTT																															ccaagaggttagtatgaagcTgagataccatatcttcagtt																										TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr4:169927998_169928000TGA>CTT	uc003iry.2	-	3	488_490	c.306_308TCA>AAG	c.(304-309)TCTCAG>TCAAGG	p.Q103R	CBR4_uc011cjy.1_RNA|CBR4_uc003irz.1_Missense_Mutation_p.Q103R	NM_032783	NP_116172	Q8N4T8	CBR4_HUMAN	carbonic reductase 4	103					fatty acid biosynthetic process|protein homotetramerization	mitochondrial matrix	NADPH binding|NADPH dehydrogenase (quinone) activity|protein binding|quinone binding				0		Prostate(90;0.00263)|Renal(120;0.0183)|Melanoma(52;0.123)		GBM - Glioblastoma multiforme(119;0.0321)		AGTATGAAGCTGAGATACCATAT	0.369													6	151					0	0	0	0	CTT	169928000	CTT	CTT	169927998	3	2	220	1	0	0	0	0	1	0	0	0	2722	1580	55	5	417	5	CBR4	4	169927998	Missense_Mutation	TNP	TGA	TCGA-CV-7097-01A-11D-2012-08	13293288	169927998	21226278	31	40448											
HMGB2	3148	broad.mit.edu	37	chr4	174254247	174254247	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttaggagcattggggtccTttttcttccccttcttatca	5	19	7	10	0	3	0	1	0	2	0	5	1	5	1	3	3	1	1	3	3	2	8			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr4:174254247T>C	uc011ckc.1	-	2	389	c.269A>G	c.(268-270)AAG>AGG	p.K90R	HMGB2_uc003ita.3_Missense_Mutation_p.K90R|HMGB2_uc003itb.2_Missense_Mutation_p.K90R|HMGB2_uc003itc.2_Missense_Mutation_p.K90R	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	90					base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		ATTGGGGTCCTTTTTCTTCCC	0.398													3	166					0	0	0	0	C	174254247	C	C	174254247	3	2	220	1	0	0	0	0	1	0	0	0	7265	1609	56	5	372	5	HMGB2	4	174254247	Missense_Mutation	SNP	T	TCGA-CV-7097-01A-11D-2012-08	4326249	174254247	16900029	32	40449											
FBXO8	26269	broad.mit.edu	37	chr4	175162340	175162340	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcctttggcgaatcatccagGatacccttggacataaagta	12	11	8	10	1	1	0	1	0	0	0	3	3	3	2	3	3	1	1	3	3	5	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr4:175162340G>T	uc003itp.2	-	4	1336	c.486C>A	c.(484-486)ATC>ATA	p.I162I	FBXO8_uc003itq.2_Silent_p.I121I	NM_012180	NP_036312	Q9NRD0	FBX8_HUMAN	F-box only protein 8	162	SEC7.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(2)	2		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		AATCATCCAGGATACCCTTGG	0.323													17	37					6.49762e-13	1.69153e-12	1	0	T	175162340	T	T	175162340	2	4	220	1	0	0	0	0	0	0	0	1	5793	1164	41	2		2	FBXO8	4	175162340	Silent	SNP	G	TCGA-CV-7097-01A-11D-2012-08	908093	175162340	15991936	33	40450											
PCDHA12	56137	broad.mit.edu	37	chr5	140256564	140256564	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcggcgggtgggcgagcacGcactgtcgagctacgtgtcg	6	6	18	11	7	0	0	0	0	0	0	2	2	0	0	0	3	4	3	0	3	1	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr5:140256564G>A	uc003lic.2	+	1	1634	c.1507G>A	c.(1507-1509)GCA>ACA	p.A503T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.A503T	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGAGCACGCACTGTCGAG	0.677													8	87					0	0	0	0	A	140256564	A	A	140256564	3	1	220	1	0	0	0	0	1	0	0	0	11576	1087	38	1	1509	1	PCDHA12	5	140256564	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08		140256564	40658696	34	40451											
KCNMB1	3779	broad.mit.edu	37	chr5	169810824	169810824	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctgatgttggtctcaatCaggtggcacttggattcctg	6	14	11	10	0	2	1	2	1	1	0	5	2	4	2	2	4	0	2	2	4	1	3	rs143181866		TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr5:169810824C>A	uc003maq.1	-	3	565	c.165G>T	c.(163-165)CTG>CTT	p.L55L	KCNIP1_uc003map.2_Intron|KCNMB1_uc003mar.2_Silent_p.L55L	NM_004137	NP_004128	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated	55	Extracellular (Potential).				platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			ovary(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		TGGTCTCAATCAGGTGGCACT	0.567													8	16					5.18039e-06	1.27486e-05	1	0	A	169810824	A	A	169810824	2	1	220	1	0	0	0	0	0	0	0	1	8113	813	29	2		2	KCNMB1	5	169810824	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08	29554260	169810824	11104436	35	40452											
HUS1B	135458	broad.mit.edu	37	chr6	656505	656505	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggaggcgcgcaggctgggcGgcaggcagtcccgccacact	6	3	17	15	5	0	0	0	0	0	0	1	1	1	1	2	6	0	4	2	6	0	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr6:656505G>A	uc003mtg.2	-	1	460	c.440C>T	c.(439-441)CCG>CTG	p.P147L	EXOC2_uc003mtd.2_Intron|EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_148959	NP_683762	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint protein B	147											0	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		CAGGCTGGGCGGCAGGCAGTC	0.716													22	40					0	0	0	0	A	656505	A	A	656505	3	1	220	1	0	0	0	0	1	0	0	0	7499	1116	39	1	400	1	HUS1B	6	656505	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08		656505	170458562	36	40453											
ABCF1	23	broad.mit.edu	37	chr6	30551996	30551997	+	Frame_Shift_Ins	INS	-	C	C																															gcagatgagacaccagcagtINSccaggctgttcttcgagctg																										TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr6:30551996_30551997insC	uc003nql.2	+	13	1225_1226	c.1130_1131insC	c.(1129-1131)GTCfs	p.V377fs	ABCF1_uc003nqk.2_Frame_Shift_Ins_p.V378fs|ABCF1_uc003nqm.2_Frame_Shift_Ins_p.V339fs|ABCF1_uc010jsb.2_Intron|MIR877_hsa-mir-877|MI0005561_5'Flank	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	377	ABC transporter 1.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						ACACCAGCAGTCCAGGCTGTTC	0.55													---	---	---								C	30551997	C	C	30551996	7	5	220	1	0	1	1	0	0	0	0	0	65	1667	58	0	1180	0	ABCF1	6	30551996	Frame_Shift_Ins	INS	-	TCGA-CV-7097-01A-11D-2012-08	29895491	30551996	140563071	37	40454											
HLA-DMA	3108	broad.mit.edu	37	chr6	32917064	32917064	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ataccacctgagcaaggcttCcggaagtagatgatgagaac	14	7	11	9	1	0	4	0	3	0	2	1	6	1	5	3	2	3	3	3	2	5	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr6:32917064C>T	uc003ocm.2	-	4	851	c.765G>A	c.(763-765)CGG>CGA	p.R255R		NM_006120	NP_006111	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM	255						integral to membrane|MHC class II protein complex					0						AGCAAGGCTTCCGGAAGTAGA	0.567													20	44					0	0	0	0	T	32917064	T	T	32917064	2	4	220	1	0	0	0	0	0	0	0	1	7237	842	30	2		2	HLA-DMA	6	32917064	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08	2365068	32917064	138198003	38	40455											
NCR2	9436	broad.mit.edu	37	chr6	41309847	41309847	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgttctgtggactcctcGtagccaagagcctggtgctg	5	12	13	11	1	1	1	0	0	1	1	3	2	2	2	3	2	3	3	3	2	2	2	rs149275592	byFrequency	TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr6:41309847G>A	uc003oqh.2	+	4	691	c.604G>A	c.(604-606)GTA>ATA	p.V202I	NCR2_uc003oqi.2_Missense_Mutation_p.V214I|NCR2_uc003oqj.2_Missense_Mutation_p.V202I	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	202	Helical; (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					TGGACTCCTCGTAGCCAAGAG	0.622													41	93					0	0	0	0	A	41309847	A	A	41309847	3	1	220	1	0	0	0	0	1	0	0	0	10292	1145	40	1	618	1	NCR2	6	41309847	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	8392783	41309847	129805220	39	40456											
ZNF318	24149	broad.mit.edu	37	chr6	43305058	43305058	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagggtcgccactgtcatcAtctacttgcagaattgccac	10	10	9	12	1	3	2	2	0	1	2	4	2	3	2	2	1	3	1	2	1	2	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr6:43305058A>G	uc003oux.2	-	10	6756	c.6678T>C	c.(6676-6678)GAT>GAC	p.D2226D	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2226					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CACTGTCATCATCTACTTGCA	0.493													16	37					0	0	0	0	G	43305058	G	G	43305058	2	3	220	1	0	0	0	0	0	0	0	1	17903	214	8	5		5	ZNF318	6	43305058	Silent	SNP	A	TCGA-CV-7097-01A-11D-2012-08	1995211	43305058	127810009	40	40457											
RFX6	222546	broad.mit.edu	37	chr6	117237221	117237221	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgccagtgtatcctggaCaatgcaattaatggaaactt	13	11	8	9	0	0	0	0	0	0	0	1	2	1	2	2	2	3	2	2	2	5	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr6:117237221C>A	uc003pxm.2	+	8	894	c.831C>A	c.(829-831)GAC>GAA	p.D277E		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	277					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GTATCCTGGACAATGCAATTA	0.343													13	52					5.50884e-06	1.34518e-05	1	0	A	117237221	A	A	117237221	3	1	220	1	0	0	0	0	1	0	0	0	13332	477	17	4	861	4	RFX6	6	117237221	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	73932163	117237221	53877846	41	40458											
SYNJ2	8871	broad.mit.edu	37	chr6	158517350	158517350	+	Frame_Shift_Del	DEL	A	-	-																															ggtgacaatcagtgaccaagAaaagaggacagcactgcagg																										TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr6:158517350delA	uc003qqx.1	+	27	4520	c.4445delA	c.(4444-4446)GAAfs	p.E1482fs	SYNJ2_uc003qqy.1_Frame_Shift_Del_p.E1195fs|SYNJ2_uc003qqz.1_Frame_Shift_Del_p.E1099fs|SYNJ2_uc003qra.1_Frame_Shift_Del_p.E825fs|SYNJ2_uc010kjp.1_Frame_Shift_Del_p.E365fs	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1482	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		AGTGACCAAGAAAAGAGGACA	0.507													---	---	---								-	158517350	-	-	158517350	7	5	220	1	0	1	0	1	0	0	0	0	15519	246	9	0	4551	0	SYNJ2	6	158517350	Frame_Shift_Del	DEL	A	TCGA-CV-7097-01A-11D-2012-08	41280129	158517350	12597717	42	40459											
T	6862	broad.mit.edu	37	chr6	166571825	166571825	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatggaaggtggcgacacaGgtgtccatgaggctatgagg	11	7	16	7	1	0	2	0	2	0	0	1	4	1	3	1	6	0	1	1	6	2	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr6:166571825G>T	uc003quu.1	-	9	1779	c.1286C>A	c.(1285-1287)CCT>CAT	p.P429H	T_uc003qut.1_Missense_Mutation_p.P430H|T_uc003quv.1_Missense_Mutation_p.P371H	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	429					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		TGGCGACACAGGTGTCCATGA	0.612									Chordoma_Familial_Clustering_of				14	158					1.05317e-09	2.67539e-09	1	0	T	166571825	T	T	166571825	3	4	220	1	0	0	0	0	1	0	0	0	15554	1000	35	4	25	4	T	6	166571825	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	8054475	166571825	4543242	43	40460											
DDC	1644	broad.mit.edu	37	chr7	50605594	50605594	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttctccagctttctcattCaaaaatgcctttggtagttc	8	16	5	12	0	3	0	2	0	2	0	6	0	3	0	3	1	2	3	3	1	3	6			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr7:50605594C>G	uc003tpf.3	-	4	485	c.399G>C	c.(397-399)TTG>TTC	p.L133F	DDC_uc010kza.2_Intron|DDC_uc003tpg.3_Missense_Mutation_p.L133F	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	133	2.|2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CTTTCTCATTCAAAAATGCCT	0.572													22	64					0	0	0	0	G	50605594	G	G	50605594	3	3	220	1	0	0	0	0	1	0	0	0	4342	825	29	2	1087	2	DDC	7	50605594	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08		50605594	108533069	44	40461											
WBSCR17	64409	broad.mit.edu	37	chr7	70597919	70597920	+	Frame_Shift_Del	DEL	CG	-	-																															cgccttccacgagatccggcCgcgcgccgaggtggccaacc																										TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr7:70597919_70597920delCG	uc003tvy.2	+	1	131_132	c.131_132delCG	c.(130-132)CCGfs	p.P44fs		NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	44	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GAGATCCGGCCGCGCGCCGAGG	0.678													---	---	---								-	70597920	-	-	70597919	7	5	220	1	0	1	0	1	0	0	0	0	17332	652	23	0	133	0	WBSCR17	7	70597919	Frame_Shift_Del	DEL	CG	TCGA-CV-7097-01A-11D-2012-08	19992325	70597919	88540744	45	40462											
ZNF804B	219578	broad.mit.edu	37	chr7	88963629	88963629	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaccactaccttttctcCacgttcaaagcaaggatggc	12	10	6	13	1	2	0	1	0	1	0	3	1	2	1	3	2	3	2	3	2	5	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr7:88963629C>G	uc011khi.1	+	4	1871	c.1333C>G	c.(1333-1335)CAC>GAC	p.H445D		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	445						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ACCTTTTCTCCACGTTCAAAG	0.398										HNSCC(36;0.09)			3	59					0	0	0	0	G	88963629	G	G	88963629	3	3	220	1	0	0	0	0	1	0	0	0	18238	594	21	4	1347	4	ZNF804B	7	88963629	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	18365710	88963629	70175034	46	40463											
MUC17	140453	broad.mit.edu	37	chr7	100677784	100677784	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctcctcccactgctgaaggTaccagcatgccaacctcaac	10	7	6	18	0	1	1	1	1	0	0	3	1	3	1	6	1	6	3	6	1	4	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr7:100677784T>C	uc003uxp.1	+	3	3140	c.3087T>C	c.(3085-3087)GGT>GGC	p.G1029G	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1029	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|15.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGCTGAAGGTACCAGCATGC	0.502													178	464					0	0	0	0	C	100677784	C	C	100677784	2	2	220	1	0	0	0	0	0	0	0	1	10027	1625	57	5		5	MUC17	7	100677784	Silent	SNP	T	TCGA-CV-7097-01A-11D-2012-08	11714155	100677784	58460879	47	40464											
TRPV6	55503	broad.mit.edu	37	chr7	142569486	142569486	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatattcccagctctcccCgtcctccagacccctgttga	6	11	6	18	1	1	3	0	2	1	1	5	3	4	3	7	0	1	2	7	0	1	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr7:142569486C>T	uc003wbx.1	-	15	2368	c.2152G>A	c.(2152-2154)GGG>AGG	p.G718R	TRPV6_uc003wbw.1_Missense_Mutation_p.G504R|TRPV6_uc010lou.1_Missense_Mutation_p.G589R	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	718	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CAGCTCTCCCCGTCCTCCAGA	0.527													26	76					0	0	0	0	T	142569486	T	T	142569486	3	4	220	1	0	0	0	0	1	0	0	0	16667	652	23	1	29	1	TRPV6	7	142569486	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	41891702	142569486	16569177	48	40465											
WDR60	55112	broad.mit.edu	37	chr7	158695196	158695196	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacaagaaattcaaagagctAttaatgcagaaaatgaaagg	21	8	8	4	0	1	4	1	1	0	3	1	4	1	4	0	1	3	2	0	1	9	4			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr7:158695196A>T	uc003woe.3	+	10	1425	c.1267A>T	c.(1267-1269)ATT>TTT	p.I423F	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_5'UTR	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	423	Potential.									ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TCAAAGAGCTATTAATGCAGA	0.368													19	67					0	0	0	0	T	158695196	T	T	158695196	3	4	220	1	0	0	0	0	1	0	0	0	17379	449	16	5	1305	5	WDR60	7	158695196	Missense_Mutation	SNP	A	TCGA-CV-7097-01A-11D-2012-08	16125710	158695196	443467	49	40466											
DMRT3	58524	broad.mit.edu	37	chr9	990054	990054	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttccagatttgactgaagaAcgacttggagacggcaagtc	12	10	11	8	2	0	5	0	2	0	3	2	7	1	5	1	2	1	1	1	2	3	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr9:990054A>G	uc003zgw.1	+	2	506	c.468A>G	c.(466-468)GAA>GAG	p.E156E		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	156					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		TGACTGAAGAACGACTTGGAG	0.478													10	79					0	0	0	0	G	990054	G	G	990054	2	3	220	1	0	0	0	0	0	0	0	1	4609	40	2	5		5	DMRT3	9	990054	Silent	SNP	A	TCGA-CV-7097-01A-11D-2012-08		990054	140223377	50	40467											
IFNA13	3447	broad.mit.edu	37	chr9	21367983	21367983	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagcaccaccagggccatCagtaaagcaaagggcgaggc	13	3	13	12	1	1	1	1	1	0	0	1	2	1	1	3	3	2	3	3	3	3	1	rs147549496	byFrequency	TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr9:21367983C>T	uc003zpa.2	-	1	93	c.27G>A	c.(25-27)CTG>CTA	p.L9L		NM_006900	NP_008831	P01562	IFNA1_HUMAN	interferon, alpha 13 precursor	8					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)	1				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)		CCAGGGCCATCAGTAAAGCAA	0.547													78	49					0	0	0	0	T	21367983	T	T	21367983	2	4	220	1	0	0	0	0	0	0	0	1	7572	813	29	2		2	IFNA13	9	21367983	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08	20377929	21367983	119845448	51	40468											
CEP110	11064	broad.mit.edu	37	chr9	123904513	123904513	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctgatgaagagaaggagAgaattctggcccaactccga	15	6	12	8	1	1	4	0	2	1	2	2	8	2	5	2	2	2	1	2	2	5	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr9:123904513A>C	uc004bkx.1	+	17	2867	c.2836A>C	c.(2836-2838)AGA>CGA	p.R946R	CEP110_uc004bky.1_Silent_p.R550R|CEP110_uc004bla.1_Silent_p.R394R|CEP110_uc010mvo.1_5'Flank	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	946	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AGAGAAGGAGAGAATTCTGGC	0.438													8	28					0	0	0	0	C	123904513	C	C	123904513	2	2	220	1	0	0	0	0	0	0	0	1	3260	296	11	5		5	CEP110	9	123904513	Silent	SNP	A	TCGA-CV-7097-01A-11D-2012-08	102536530	123904513	17308918	52	40469											
ODF2	4957	broad.mit.edu	37	chr9	131233667	131233667	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctggaggaggtggcccaCgaactggctgagactgagca	10	5	17	9	1	0	2	0	2	0	1	0	7	0	4	1	5	3	3	1	5	1	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr9:131233667C>T	uc011mbd.1	+	6	812	c.501C>T	c.(499-501)CAC>CAT	p.H167H	ODF2_uc011maz.1_Silent_p.H167H|ODF2_uc011mba.1_Intron|ODF2_uc010myb.2_Silent_p.H143H|ODF2_uc011mbb.1_Silent_p.H101H|ODF2_uc011mbc.1_Silent_p.H86H|ODF2_uc004bva.2_Silent_p.H120H|ODF2_uc004bvb.2_Silent_p.H143H|ODF2_uc011mbe.1_Silent_p.H162H|ODF2_uc004bvc.2_Silent_p.H143H|ODF2_uc010myc.2_Silent_p.H110H|ODF2_uc011mbf.1_Silent_p.H148H|ODF2_uc004bvd.3_Silent_p.H167H|ODF2_uc004bve.2_Silent_p.H148H	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	167	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						AGGTGGCCCACGAACTGGCTG	0.577													32	41					0	0	0	0	T	131233667	T	T	131233667	2	4	220	1	0	0	0	0	0	0	0	1	10881	535	19	1		1	ODF2	9	131233667	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08	7329154	131233667	9979764	53	40470											
SETX	23064	broad.mit.edu	37	chr9	135139785	135139786	+	Missense_Mutation	DNP	CG	AT	AT																															ctgtgacagagctcctcttcCgggtcatcacatttgctctg																										TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	30516b25-d2b1-44e1-8414-4b37a66167eb	g.chr9:135139785_135139786CG>AT	uc004cbk.2	-	26	8057_8058	c.7874_7875CG>AT	c.(7873-7875)CCG>CAT	p.P2625H	SETX_uc004cbj.2_Missense_Mutation_p.P2273H|SETX_uc010mzt.2_Missense_Mutation_p.P2211H	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2625					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GCTCCTCTTCCGGGTCATCACA	0.599													5	233					0	0	0	0	AT	135139786	AT	AT	135139785	3	1	220	1	0	0	0	0	1	0	0	0	14206	639	23	3	162	3	SETX	9	135139785	Missense_Mutation	DNP	CG	TCGA-CV-7097-01A-11D-2012-08	3906118	135139785	6073646	54	40471											
LCNL1	401562	broad.mit.edu	37	chr9	139879316	139879316	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agacccagacacccccgcttCgggtctgggatgtcacccct	7	7	10	17	2	2	2	1	0	1	2	3	3	2	3	5	2	0	1	5	2	0	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	30516b25-d2b1-44e1-8414-4b37a66167eb	g.chr9:139879316C>T	uc004ckh.1	+	3	942	c.348C>T	c.(346-348)TTC>TTT	p.F116F		NM_207510	NP_997393	Q6ZST4	LCNL1_HUMAN	lipocalin-like 1	116							binding				0						ACCCCCGCTTCGGGTCTGGGA	0.642													4	1					0	0	0	0	T	139879316	T	T	139879316	2	4	220	1	0	0	0	0	0	0	0	1	8728	883	31	1		1	LCNL1	9	139879316	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08	4739531	139879316	1334115	55	40472											
TSPAN14	81619	broad.mit.edu	37	chr10	82249069	82249069	+	Frame_Shift_Del	DEL	G	-	-																															cagctacaacatcatcttctGggtaagtggatgagagctgc																										TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr10:82249069delG	uc001kcj.3	+	2	187	c.80delG	c.(79-81)TGGfs	p.W27fs	TSPAN14_uc009xss.2_Frame_Shift_Del_p.W27fs|TSPAN14_uc001kci.3_Frame_Shift_Del_p.W27fs	NM_030927	NP_112189	Q8NG11	TSN14_HUMAN	tetraspanin 14 isoform 1	27	Helical; (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)			ATCATCTTCTGGGTAAGTGGA	0.308													---	---	---								-	82249069	-	-	82249069	7	5	220	1	0	1	0	1	0	0	0	0	16705	1362	47	0	82	0	TSPAN14	10	82249069	Frame_Shift_Del	DEL	G	TCGA-CV-7097-01A-11D-2012-08		82249069	53285678	56	40473											
OR52E2	119678	broad.mit.edu	37	chr11	5080067	5080067	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggcacatttcggccaaagCgatgagtcataaaggaaaag	15	6	13	7	2	1	1	1	1	0	0	2	3	1	2	1	4	1	1	1	4	5	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr11:5080067C>T	uc010qyw.1	-	1	791	c.791G>A	c.(790-792)TGC>TAC	p.C264Y		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		TCGGCCAAAGCGATGAGTCAT	0.473													6	75					0	0	0	0	T	5080067	T	T	5080067	3	4	220	1	0	0	0	0	1	0	0	0	11169	768	27	1	189	1	OR52E2	11	5080067	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08		5080067	129926449	57	40474											
OR51B2	79345	broad.mit.edu	37	chr11	5345445	5345445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acacataaacagcaaagaagGggatggagatccagtgatga	18	5	12	6	0	0	4	0	2	0	2	1	6	1	5	1	3	2	1	1	3	4	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr11:5345445G>A	uc001mao.1	-	1	138	c.83C>T	c.(82-84)CCC>CTC	p.P28L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCAAAGAAGGGGATGGAGAT	0.502											OREG0003719	type=REGULATORY REGION|Gene=OR51B2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	12	37					0	0	0	0	A	5345445	A	A	5345445	3	1	220	1	0	0	0	0	1	0	0	0	11143	1232	43	4	859	4	OR51B2	11	5345445	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	265378	5345445	129661071	58	40475											
OR52N1	79473	broad.mit.edu	37	chr11	5809698	5809698	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtccagggccatgagcatgaGcaccccagactccatccctg	9	6	10	16	0	0	3	0	2	0	1	3	3	3	3	6	1	2	2	6	1	0	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr11:5809698G>C	uc010qzo.1	-	1	349	c.349C>G	c.(349-351)CTC>GTC	p.L117V	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ATGAGCATGAGCACCCCAGAC	0.498													22	77					0	0	0	0	C	5809698	C	C	5809698	3	2	220	1	0	0	0	0	1	0	0	0	11181	971	34	4	616	4	OR52N1	11	5809698	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	464253	5809698	129196818	59	40476											
MRGPRX3	117195	broad.mit.edu	37	chr11	18158957	18158957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacatcctcaacctggtcGcggccgacttcctcttcctt	5	13	6	17	3	3	0	1	0	2	0	7	1	6	0	5	2	2	0	5	2	2	4	rs145864519		TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr11:18158957G>A	uc001mnu.2	+	3	569	c.208G>A	c.(208-210)GCG>ACG	p.A70T		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	70	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						CAACCTGGTCGCGGCCGACTT	0.567													44	76					0	0	0	0	A	18158957	A	A	18158957	3	1	220	1	0	0	0	0	1	0	0	0	9821	1087	38	1	210	1	MRGPRX3	11	18158957	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	12349259	18158957	116847559	60	40477											
SPRYD5	84767	broad.mit.edu	37	chr11	55653151	55653151	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccagaaaagccagcctcCggcaattccttagctctgag	10	9	9	13	1	1	2	0	1	1	1	3	2	3	2	5	1	4	2	5	1	4	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr11:55653151C>T	uc010rip.1	+	2	339	c.247C>T	c.(247-249)CGG>TGG	p.R83W	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	83						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				AGCCAGCCTCCGGCAATTCCT	0.483													7	14					0	0	0	0	T	55653151	T	T	55653151	3	4	220	1	0	0	0	0	1	0	0	0	15177	643	23	1	249	1	SPRYD5	11	55653151	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	37494194	55653151	79353365	61	40478											
MPZL3	196264	broad.mit.edu	37	chr11	118107898	118107898	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atagatgcatcccctttgtaTacatttccaacccaggaaat	13	12	5	11	0	0	1	0	0	0	1	2	2	2	2	4	1	3	2	4	1	5	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr11:118107898T>C	uc001psm.2	-	3	320	c.318A>G	c.(316-318)GTA>GTG	p.V106V	MPZL3_uc010rxy.1_Silent_p.V94V|MPZL3_uc010rxz.1_Intron|MPZL3_uc009yzy.2_Intron	NM_198275	NP_938016	Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3 precursor	106	Ig-like V-type.				cell adhesion	integral to membrane					0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		CCCCTTTGTATACATTTCCAA	0.428													61	71					0	0	0	0	C	118107898	C	C	118107898	2	2	220	1	0	0	0	0	0	0	0	1	9804	1393	49	5		5	MPZL3	11	118107898	Silent	SNP	T	TCGA-CV-7097-01A-11D-2012-08	62454747	118107898	16898618	62	40479											
OR8B2	26595	broad.mit.edu	37	chr11	124252465	124252465	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccagaagaatatttaatatAcatgaatgccgctgacccaa	16	10	6	9	1	0	4	0	2	0	2	1	4	1	4	3	0	2	1	3	0	8	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	30516b25-d2b1-44e1-8414-4b37a66167eb	g.chr11:124252465A>G	uc010sai.1	-	1	775	c.775T>C	c.(775-777)TAT>CAT	p.Y259H		NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TATTTAATATACATGAATGCC	0.403													3	68					0	0	0	0	G	124252465	G	G	124252465	3	3	220	1	0	0	0	0	1	0	0	0	11281	391	14	5	169	5	OR8B2	11	124252465	Missense_Mutation	SNP	A	TCGA-CV-7097-01A-11D-2012-08	6144567	124252465	10754051	63	40480											
ADAMTS20	80070	broad.mit.edu	37	chr12	43777690	43777690	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaacaaggtcgggtggactGatcacacatttcttcaacca	13	9	9	10	1	3	2	2	1	1	1	4	3	3	3	1	3	2	0	1	3	3	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr12:43777690G>A	uc010skx.1	-	30	4543	c.4543C>T	c.(4543-4545)CAG>TAG	p.Q1515*		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1515	TSP type-1 12.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CGGGTGGACTGATCACACATT	0.507													22	64					0	0	0	0	A	43777690	A	A	43777690	4	1	220	1	0	0	0	0	0	1	0	0	266	1299	45	2	1228	2	ADAMTS20	12	43777690	Nonsense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08		43777690	90074205	64	40481											
SPRYD3	84926	broad.mit.edu	37	chr12	53460181	53460181	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcctcttcctcttccccttCctggtgcaggtacatgacat	5	14	6	16	0	2	1	0	1	2	0	6	1	6	1	5	2	2	2	5	2	1	4			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr12:53460181C>T	uc001sbt.1	-	10	1132	c.1111G>A	c.(1111-1113)GAA>AAA	p.E371K		NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	371	Glu-rich.									central_nervous_system(1)	1						tcttccccttcctGGTGCAGG	0.428											OREG0021856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	54					0	0	0	0	T	53460181	T	T	53460181	3	4	220	1	0	0	0	0	1	0	0	0	15175	864	30	2	225	2	SPRYD3	12	53460181	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	9682491	53460181	80391714	65	40482											
SOAT2	8435	broad.mit.edu	37	chr12	53509227	53509227	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcggacagctgccattggCgctggtgacctgggtgccca	5	9	14	13	2	0	1	0	1	0	0	1	2	0	2	3	4	3	2	3	4	0	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr12:53509227C>T	uc001sbv.2	+	6	585	c.497C>T	c.(496-498)GCG>GTG	p.A166V	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	166	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						CTGCCATTGGCGCTGGTGACC	0.612													14	29					0	0	0	0	T	53509227	T	T	53509227	3	4	220	1	0	0	0	0	1	0	0	0	14975	768	27	1	519	1	SOAT2	12	53509227	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	49046	53509227	80342668	66	40483											
IL26	55801	broad.mit.edu	37	chr12	68595690	68595690	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccagttcactgatggcttTgtagattcctttgtttccaa	8	17	7	9	0	1	2	1	1	0	1	4	2	4	2	3	1	0	4	3	1	2	6			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr12:68595690T>G	uc001stx.1	-	5	486	c.451A>C	c.(451-453)AAA>CAA	p.K151Q		NM_018402	NP_060872	Q9NPH9	IL26_HUMAN	interleukin 26 precursor	151					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		CTGATGGCTTTGTAGATTCCT	0.274													9	37					0	0	0	0	G	68595690	G	G	68595690	3	3	220	1	0	0	0	0	1	0	0	0	7718	1821	63	5	68	5	IL26	12	68595690	Missense_Mutation	SNP	T	TCGA-CV-7097-01A-11D-2012-08	15086463	68595690	65256205	67	40484											
DCN	1634	broad.mit.edu	37	chr12	91550936	91550936	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagccccattttcaattcCtgagctcttcagcggattgg	9	12	9	11	1	3	1	2	1	1	0	4	3	4	2	3	2	3	1	3	2	2	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr12:91550936C>G	uc001tbs.2	-	4	662	c.568G>C	c.(568-570)GGA>CGA	p.G190R	DCN_uc001tbo.2_Missense_Mutation_p.G81R|DCN_uc001tbp.2_Intron|DCN_uc001tbq.2_Intron|DCN_uc001tbr.2_Intron|DCN_uc001tbt.2_Missense_Mutation_p.G190R|DCN_uc001tbu.2_Missense_Mutation_p.G190R	NM_133503	NP_598010	P07585	PGS2_HUMAN	decorin isoform a preproprotein	190	LRR 6.				organ morphogenesis	extracellular space				central_nervous_system(2)|ovary(1)|lung(1)	4						TTTTCAATTCCTGAGCTCTTC	0.413													9	96					0	0	0	0	G	91550936	G	G	91550936	3	3	220	1	0	0	0	0	1	0	0	0	4314	690	24	4	527	4	DCN	12	91550936	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	22955246	91550936	42300959	68	40485											
VEZT	55591	broad.mit.edu	37	chr12	95645720	95645720	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtgtctttttcagaattCtccactttaccaatacttac	9	19	3	10	0	3	1	1	0	2	1	4	1	3	1	2	0	3	0	2	0	5	8			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr12:95645720C>A	uc001tdz.2	+	2	146	c.41C>A	c.(40-42)TCT>TAT	p.S14Y	VEZT_uc009zsy.1_5'UTR|VEZT_uc001tdr.2_5'UTR|VEZT_uc001tds.2_5'UTR|VEZT_uc001tdt.2_5'UTR|VEZT_uc009zsz.1_Missense_Mutation_p.S14Y|VEZT_uc001tdv.2_5'UTR|VEZT_uc001tdw.1_5'UTR|VEZT_uc009zta.1_5'UTR	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	14						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						TTTCAGAATTCTCCACTTTAC	0.363													19	58					1.01871e-10	2.6089e-10	1	0	A	95645720	A	A	95645720	3	1	220	1	0	0	0	0	1	0	0	0	17224	913	32	2	47	2	VEZT	12	95645720	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	4094784	95645720	38206175	69	40486											
GAS2L3	283431	broad.mit.edu	37	chr12	101018469	101018469	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taccaaaacacaaactgcacCgaagtcagcacagactgtcg	16	5	7	13	2	1	1	1	0	0	1	2	2	1	1	2	0	5	2	2	0	5	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr12:101018469C>T	uc001thu.2	+	10	2112	c.1886C>T	c.(1885-1887)CCG>CTG	p.P629L	GAS2L3_uc009zty.2_Missense_Mutation_p.P629L|GAS2L3_uc001thv.2_Missense_Mutation_p.P525L	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	629					cell cycle arrest					skin(1)	1						CAAACTGCACCGAAGTCAGCA	0.527													20	56					0	0	0	0	T	101018469	T	T	101018469	3	4	220	1	0	0	0	0	1	0	0	0	6283	652	23	1	1916	1	GAS2L3	12	101018469	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	5372749	101018469	32833426	70	40487											
ACAD10	80724	broad.mit.edu	37	chr12	112165809	112165809	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatggagtactgcccaggtCtcatctacaaagacccttcc	10	10	8	13	0	2	2	1	1	2	1	4	3	3	3	3	2	3	1	3	2	3	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr12:112165809C>G	uc001tsq.2	+	9	1305	c.1105C>G	c.(1105-1107)CTC>GTC	p.L369V	ACAD10_uc001tsp.2_Missense_Mutation_p.L369V|ACAD10_uc009zvx.2_Missense_Mutation_p.L400V|ACAD10_uc001tss.1_Intron	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	369							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						CTGCCCAGGTCTCATCTACAA	0.522													45	141					0	0	0	0	G	112165809	G	G	112165809	3	3	220	1	0	0	0	0	1	0	0	0	108	913	32	2	1232	2	ACAD10	12	112165809	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	11147340	112165809	21686086	71	40488											
RPH3A	22895	broad.mit.edu	37	chr12	113307745	113307745	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaaactatgggcctcccGtgcgcagggcctccgaggca	8	5	15	13	3	0	0	0	0	0	0	2	3	2	1	4	4	2	2	4	4	2	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr12:113307745G>A	uc010syl.1	+	10	1059	c.697G>A	c.(697-699)GTG>ATG	p.V233M	RPH3A_uc001ttz.2_Missense_Mutation_p.V233M|RPH3A_uc001tty.2_Missense_Mutation_p.V229M|RPH3A_uc009zwe.1_Missense_Mutation_p.V229M|RPH3A_uc010sym.1_Missense_Mutation_p.V184M|RPH3A_uc001tua.2_Translation_Start_Site	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	233	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		TGGGCCTCCCGTGCGCAGGGC	0.612													24	63					0	0	0	0	A	113307745	A	A	113307745	3	1	220	1	0	0	0	0	1	0	0	0	13616	1145	40	1	727	1	RPH3A	12	113307745	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	1141936	113307745	20544150	72	40489											
DNAH10	196385	broad.mit.edu	37	chr12	124416356	124416356	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaacgcttcaacaagcttGtggtccggatgacgaagtct	10	10	12	9	3	2	1	1	1	1	0	3	4	3	3	1	3	3	2	1	3	4	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr12:124416356G>T	uc001uft.3	+	74	12761	c.12736G>T	c.(12736-12738)GTG>TTG	p.V4246L	DNAH10_uc001ufu.3_Missense_Mutation_p.V159L	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4246	Potential.				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAACAAGCTTGTGGTCCGGAT	0.542													33	84					7.72975e-29	2.08109e-28	1	0	T	124416356	T	T	124416356	3	4	220	1	0	0	0	0	1	0	0	0	4620	1377	48	4	13030	4	DNAH10	12	124416356	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	11108611	124416356	9435539	73	40490											
DACT1	51339	broad.mit.edu	37	chr14	59112758	59112758	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gttccgccattgggacagggGagtcccctaaggaaagcgct	9	7	14	11	2	0	0	0	0	0	0	2	3	2	3	4	4	1	2	4	4	2	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr14:59112758G>A	uc001xdw.2	+	4	1581	c.1417G>A	c.(1417-1419)GAG>AAG	p.E473K	DACT1_uc010trv.1_Missense_Mutation_p.E192K|DACT1_uc001xdx.2_Missense_Mutation_p.E436K|DACT1_uc010trw.1_Missense_Mutation_p.E192K	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	473					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						TGGGACAGGGGAGTCCCCTAA	0.612													26	68					0	0	0	0	A	59112758	A	A	59112758	3	1	220	1	0	0	0	0	1	0	0	0	4239	1175	41	2	1431	2	DACT1	14	59112758	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08		59112758	48236782	74	40491											
PTGR2	145482	broad.mit.edu	37	chr14	74327274	74327274	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atccagtggcagagaatttcCgaatggaagaagtctattta	14	11	10	6	1	1	2	0	0	1	2	3	5	3	3	2	2	0	1	2	2	6	4			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr14:74327274C>T	uc001xow.2	+	3	230	c.70C>T	c.(70-72)CGA>TGA	p.R24*	PTGR2_uc010tue.1_Nonsense_Mutation_p.R24*|PTGR2_uc001xox.2_Nonsense_Mutation_p.R24*|ZNF410_uc001xoy.1_RNA	NM_001146154	NP_001139626	Q8N8N7	PTGR2_HUMAN	prostaglandin reductase 2	24					prostaglandin metabolic process		15-oxoprostaglandin 13-oxidase activity|zinc ion binding				0						AGAGAATTTCCGAATGGAAGA	0.284													22	38					0	0	0	0	T	74327274	T	T	74327274	4	4	220	1	0	0	0	0	0	1	0	0	12817	644	23	1	76	1	PTGR2	14	74327274	Nonsense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	15214516	74327274	33022266	75	40492											
TECPR2	9895	broad.mit.edu	37	chr14	102874944	102874944	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaattgtttattcttctctGgatctagaccaggtaaaatt	13	16	6	6	0	3	1	0	0	3	1	4	2	3	2	1	2	0	2	1	2	6	8			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr14:102874944G>C	uc001ylw.1	+	4	616	c.468G>C	c.(466-468)CTG>CTC	p.L156L	TECPR2_uc010txw.1_Silent_p.L156L|TECPR2_uc010awl.2_Silent_p.L156L|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	156	WD 2.						protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						ATTCTTCTCTGGATCTAGACC	0.338													19	48					0	0	0	0	C	102874944	C	C	102874944	2	2	220	1	0	0	0	0	0	0	0	1	15810	1335	47	4		4	TECPR2	14	102874944	Silent	SNP	G	TCGA-CV-7097-01A-11D-2012-08	28547670	102874944	4474596	76	40493											
LTK	4058	broad.mit.edu	37	chr15	41797503	41797503	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaccagaggtgatggctggcCctgggtcaggcagagggggc	7	5	20	9	0	1	3	1	1	0	2	1	4	1	3	2	7	0	2	2	7	0	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr15:41797503C>T	uc001zoa.3	-	15	2006	c.1828G>A	c.(1828-1830)GGC>AGC	p.G610S	LTK_uc001zob.3_Missense_Mutation_p.G549S|LTK_uc010ucx.1_Missense_Mutation_p.G480S|LTK_uc010bcg.2_Missense_Mutation_p.G308S	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	610	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		GATGGCTGGCCCTGGGTCAGG	0.597										TSP Lung(18;0.14)			5	44					0	0	0	0	T	41797503	T	T	41797503	3	4	220	1	0	0	0	0	1	0	0	0	9130	637	22	4	790	4	LTK	15	41797503	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08		41797503	60733889	77	40494											
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42137429	42137429	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcacaagctctcagatcaacGggaggccctgagtcatggcc	10	7	11	13	1	4	2	4	1	1	1	5	3	4	3	2	3	2	1	2	3	2	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	30516b25-d2b1-44e1-8414-4b37a66167eb	g.chr15:42137429G>T	uc010bco.2	+	14	1369	c.1268G>T	c.(1267-1269)CGG>CTG	p.R423L	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.R654L|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.R654L|JMJD7-PLA2G4B_uc001zoq.3_Missense_Mutation_p.R124L|JMJD7-PLA2G4B_uc001zor.1_Missense_Mutation_p.R124L	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	423	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						TCAGATCAACGGGAGGCCCTG	0.582													4	34					0.00024832	0.000949576	1	0	T	42137429	T	T	42137429	3	4	220	1	0	0	0	0	1	0	0	0	7994	1116	39	3	2035	3	JMJD7-PLA2G4B	15	42137429	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	339926	42137429	60393963	78	40495											
PSTPIP1	9051	broad.mit.edu	37	chr15	77310547	77310547	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gctgcagcggcttctggatgGcaggaagatgtgcaaagaca	11	7	15	8	1	1	2	0	0	1	2	1	4	1	4	0	4	3	5	0	4	2	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	30516b25-d2b1-44e1-8414-4b37a66167eb	g.chr15:77310547G>A	uc002bcf.2	+	2	545	c.95G>A	c.(94-96)GGC>GAC	p.G32D	PSTPIP1_uc010bkt.1_RNA|PSTPIP1_uc010umo.1_5'UTR|PSTPIP1_uc010bku.1_Missense_Mutation_p.G23D|PSTPIP1_uc002bcg.2_Missense_Mutation_p.G32D|PSTPIP1_uc010bkv.1_RNA|PSTPIP1_uc010bkw.1_Missense_Mutation_p.G32D	NM_003978	NP_003969	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting	32	FCH.				cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			ovary(1)	1						CTTCTGGATGGCAGGAAGATG	0.627													4	6					0	0	0	0	A	77310547	A	A	77310547	3	1	220	1	0	0	0	0	1	0	0	0	12783	1203	42	4	101	4	PSTPIP1	15	77310547	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	35173118	77310547	25220845	79	40496											
SEMA4B	10509	broad.mit.edu	37	chr15	90771407	90771407	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaggacggggtggcagaccaAacagatgagggtggcagtgt	11	5	19	6	1	0	3	0	1	0	2	0	5	0	4	1	6	1	2	1	6	1	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr15:90771407A>T	uc002boy.2	+	15	2329	c.2046A>T	c.(2044-2046)CAA>CAT	p.Q682H	SEMA4B_uc002boz.2_Missense_Mutation_p.Q682H|SEMA4B_uc010uqd.1_Missense_Mutation_p.Q520H|SEMA4B_uc002bpa.2_Missense_Mutation_p.Q520H|SEMA4B_uc010bnv.1_Missense_Mutation_p.Q320H	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			TGGCAGACCAAACAGATGAGG	0.607													5	17					0	0	0	0	T	90771407	T	T	90771407	3	4	220	1	0	0	0	0	1	0	0	0	14097	11	1	5	2100	5	SEMA4B	15	90771407	Missense_Mutation	SNP	A	TCGA-CV-7097-01A-11D-2012-08	13460860	90771407	11759985	80	40497											
UBN1	29855	broad.mit.edu	37	chr16	4897141	4897141	+	5'Flank	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccgcgacctggagcgcataaAaaggcagctccagggccggc	10	3	14	14	4	0	0	0	0	0	0	1	2	1	1	4	4	2	3	4	4	3	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	30516b25-d2b1-44e1-8414-4b37a66167eb	g.chr16:4897141A>G	uc002cyb.2	+						GLYR1_uc002cxx.3_Intron|GLYR1_uc002cxy.2_Intron|GLYR1_uc002cxz.1_5'Flank|GLYR1_uc002cya.2_Intron|GLYR1_uc010uxv.1_Intron|UBN1_uc010uxw.1_5'UTR	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1						chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						GAGCGCATAAAAAGGCAGCTC	0.731													2	6					0	0	0	0	G	4897141	G	G	4897141	1	3	220	0	1	0	0	0	0	0	0	0	16960	29	1	5		5	UBN1	16	4897141	5'Flank	SNP	A	TCGA-CV-7097-01A-11D-2012-08		4897141	85457612	81	40498											
CIITA	4261	broad.mit.edu	37	chr16	11016081	11016081	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcttggctcgtgtgcttccGgacatggtgtccctccgggt	3	12	14	12	3	0	0	0	0	0	0	4	1	3	1	3	4	2	3	3	4	0	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr16:11016081G>A	uc002dai.3	+	17	3340	c.3207G>A	c.(3205-3207)CCG>CCA	p.P1069P	CIITA_uc002daj.3_Silent_p.P1070P|CIITA_uc002dak.3_Silent_p.P485P	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	1069					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						GTGTGCTTCCGGACATGGTGT	0.627			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								36	138					0	0	0	0	A	11016081	A	A	11016081	2	1	220	1	0	0	0	0	0	0	0	1	3443	1103	39	1		1	CIITA	16	11016081	Silent	SNP	G	TCGA-CV-7097-01A-11D-2012-08	6118940	11016081	79338672	82	40499											
NOL3	8996	broad.mit.edu	37	chr16	67208838	67208838	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgacttcgaggaaagggacGagtccgaaggtgtgagtccg	10	6	16	9	5	0	1	0	1	0	0	3	7	2	3	3	3	0	0	3	3	2	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr16:67208838G>A	uc010vjd.1	+	3	793	c.786G>A	c.(784-786)ACG>ACA	p.T262T	NOL3_uc010vjc.1_Missense_Mutation_p.E266K|NOL3_uc002erp.2_Missense_Mutation_p.E204K			O60936	NOL3_HUMAN	RecName: Full=Nucleolar protein 3; AltName: Full=Apoptosis repressor with CARD; AltName: Full=Muscle-enriched cytoplasmic protein;          Short=Myp; AltName: Full=Nucleolar protein of 30 kDa;          Short=Nop30;	200					anti-apoptosis|apoptosis|mRNA processing|RNA splicing	cytosol|nucleolus	identical protein binding|RNA binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		GGAAAGGGACGAGTCCGAAGG	0.363													22	36					0	0	0	0	A	67208838	A	A	67208838	2	1	220	1	0	0	0	0	0	0	0	1	10577	1059	37	1		1	NOL3	16	67208838	Silent	SNP	G	TCGA-CV-7097-01A-11D-2012-08	56192757	67208838	23145915	83	40500											
CHST4	10164	broad.mit.edu	37	chr16	71571103	71571103	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccgctcctacagccacgtgGtgctcaaggaggtgcgcttc	6	8	13	14	3	1	0	1	0	0	0	3	1	2	1	3	3	4	3	3	3	2	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr16:71571103G>C	uc002fan.2	+	2	704	c.523G>C	c.(523-525)GTG>CTG	p.V175L	CHST4_uc002fao.2_Missense_Mutation_p.V175L	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	175	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						CAGCCACGTGGTGCTCAAGGA	0.617													3	68					0	0	0	0	C	71571103	C	C	71571103	3	2	220	1	0	0	0	0	1	0	0	0	3421	1261	44	4	525	4	CHST4	16	71571103	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	4362265	71571103	18783650	84	40501											
CHST6	4166	broad.mit.edu	37	chr16	75513153	75513153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgatgcgtaggttgagcgCggggtcgctgagcagcgggt	6	7	19	9	6	0	2	0	2	0	0	1	3	0	2	0	4	4	4	0	4	1	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr16:75513153C>T	uc002fef.2	-	3	754	c.574G>A	c.(574-576)GCG>ACG	p.A192T	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.A192T	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	192	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGGTTGAGCGCGGGGTCGCTG	0.692													13	49					0	0	0	0	T	75513153	T	T	75513153	3	4	220	1	0	0	0	0	1	0	0	0	3423	768	27	1	617	1	CHST6	16	75513153	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	3942050	75513153	14841600	85	40502											
CDYL2	124359	broad.mit.edu	37	chr16	80718469	80718469	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagtgtagcgtgattcacGtcacattcacccatatcttg	9	12	8	12	2	4	1	3	1	1	0	4	1	4	1	2	0	1	1	2	0	2	5	rs149647231	byFrequency	TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr16:80718469G>A	uc002ffs.2	-	2	687	c.582C>T	c.(580-582)GAC>GAT	p.D194D		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	194						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						CGTGATTCACGTCACATTCAC	0.527													15	59					0	0	0	0	A	80718469	A	A	80718469	2	1	220	1	0	0	0	0	0	0	0	1	3201	1136	40	1		1	CDYL2	16	80718469	Silent	SNP	G	TCGA-CV-7097-01A-11D-2012-08	5205316	80718469	9636284	86	40503											
TP53	7157	broad.mit.edu	37	chr17	7576840	7576851	+	Splice_Site	DEL	CAAGACTTAGTA	-	-																															ttccacttgataagaggtccCaagacttagtacctgaaggg																								rs1800899	by1000genomes	TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr17:7576840_7576851delCAAGACTTAGTA	uc002gim.2	-	9	1187	c.993_splice	c.e9+1	p.Q331_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.Q331_splice|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_Splice_Site_p.Q199_splice|TP53_uc010cng.1_Splice_Site_p.Q199_splice|TP53_uc002gii.1_Splice_Site_p.Q199_splice|TP53_uc010cnh.1_Splice_Site_p.Q331_splice|TP53_uc010cni.1_Splice_Site_p.Q331_splice|TP53_uc002gij.2_Splice_Site_p.Q331_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(10)|p.0?(7)|p.I332fs*49(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TAAGAGGTCCCAAGACTTAGTACCTGAAGGGT	0.472		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7576851	-	-	7576840	8	5	220	1	0	1	0	1	0	0	1	0	16448	609	21	0		0	TP53	17	7576840	Splice_Site	DEL	CAAGACTTAGTA	TCGA-CV-7097-01A-11D-2012-08		7576840	73618370	87	40504											
MYH2	4620	broad.mit.edu	37	chr17	10440764	10440764	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctggaagttggcagacttGcccaggtgctggtcatacag	8	11	13	9	0	2	1	1	0	1	1	2	2	2	2	1	4	3	3	1	4	2	4			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr17:10440764G>C	uc010coi.2	-	16	1811	c.1683C>G	c.(1681-1683)GGC>GGG	p.G561G	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.G561G|MYH2_uc010coj.2_Silent_p.G561G	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	561	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TGGCAGACTTGCCCAGGTGCT	0.517													7	127					0	0	0	0	C	10440764	C	C	10440764	2	2	220	1	0	0	0	0	0	0	0	1	10088	1306	46	4		4	MYH2	17	10440764	Silent	SNP	G	TCGA-CV-7097-01A-11D-2012-08	2863924	10440764	70754446	88	40505											
BRCA1	672	broad.mit.edu	37	chr17	41228515	41228515	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttcttacctttccactcCtggttctttatttttactgg	4	22	5	10	0	2	0	0	0	2	0	4	0	4	0	3	2	2	2	3	2	3	9			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr17:41228515C>T	uc002icq.2	-	13	4706	c.4474G>A	c.(4474-4476)GGA>AGA	p.G1492R	BRCA1_uc010whp.1_Missense_Mutation_p.G341R|BRCA1_uc010whl.1_Missense_Mutation_p.G388R|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.G1421R|BRCA1_uc002icu.2_Missense_Mutation_p.G388R|BRCA1_uc010cyx.2_Missense_Mutation_p.G1445R|BRCA1_uc002ict.2_Missense_Mutation_p.G1513R|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Missense_Mutation_p.G221R|BRCA1_uc002idc.1_Missense_Mutation_p.G388R|BRCA1_uc010whr.1_Missense_Mutation_p.G342R	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1492					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTTTCCACTCCTGGTTCTTTA	0.358			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			17	49					0	0	0	0	T	41228515	T	T	41228515	3	4	220	1	0	0	0	0	1	0	0	0	1503	690	24	4	1161	4	BRCA1	17	41228515	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	30787751	41228515	39966695	89	40506											
BCAS3	54828	broad.mit.edu	37	chr17	59115269	59115269	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatcagtccaaacaagttgtAgttgagtccctgtacattat	12	13	8	8	0	1	1	1	1	0	0	3	2	3	1	2	0	2	4	2	0	5	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr17:59115269A>G	uc002iyv.3	+	19	1936	c.1827A>G	c.(1825-1827)GTA>GTG	p.V609V	BCAS3_uc010wow.1_Silent_p.V381V|BCAS3_uc002iyu.3_Silent_p.V594V|BCAS3_uc002iyw.3_Silent_p.V590V|BCAS3_uc002iyy.3_Silent_p.V365V|BCAS3_uc002iyz.3_Silent_p.V163V|BCAS3_uc002iza.3_Silent_p.V148V	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	609						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			AACAAGTTGTAGTTGAGTCCC	0.428													4	267					0	0	0	0	G	59115269	G	G	59115269	2	3	220	1	0	0	0	0	0	0	0	1	1354	407	15	5		5	BCAS3	17	59115269	Silent	SNP	A	TCGA-CV-7097-01A-11D-2012-08	17886754	59115269	22079941	90	40507											
DCAF7	10238	broad.mit.edu	37	chr17	61661062	61661062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acctggccaccatggccatgGatggaatggaggtgagcact	10	7	14	10	0	0	1	0	1	0	0	0	4	0	4	4	6	1	1	4	6	1	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr17:61661062G>A	uc002jbc.2	+	6	944	c.727G>A	c.(727-729)GAT>AAT	p.D243N	DCAF7_uc002jbb.2_RNA|DCAF7_uc010wpn.1_Intron	NM_005828	NP_005819	P61962	DCAF7_HUMAN	WD-repeat protein	243					multicellular organismal development	CUL4 RING ubiquitin ligase complex|cytoplasm|nucleus	protein binding			ovary(1)	1						CATGGCCATGGATGGAATGGA	0.488													13	38					0	0	0	0	A	61661062	A	A	61661062	3	1	220	1	0	0	0	0	1	0	0	0	4292	1174	41	2	746	2	DCAF7	17	61661062	Missense_Mutation	SNP	G	TCGA-CV-7097-01A-11D-2012-08	2545793	61661062	19534148	91	40508											
KIF19	124602	broad.mit.edu	37	chr17	72341019	72341019	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcgccagcgcagccgggtCaagaacatcttgcaggaggt	9	6	15	11	3	2	1	1	0	1	1	2	2	2	2	2	3	5	2	2	3	2	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr17:72341019C>T	uc002jkm.3	+	7	840	c.702C>T	c.(700-702)GTC>GTT	p.V234V	KIF19_uc002jkj.2_Silent_p.V234V|KIF19_uc002jkk.2_Silent_p.V192V|KIF19_uc002jkl.2_Silent_p.V192V	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	234	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GCAGCCGGGTCAAGAACATCT	0.697													10	26					0	0	0	0	T	72341019	T	T	72341019	2	4	220	1	0	0	0	0	0	0	0	1	8321	813	29	2		2	KIF19	17	72341019	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08	10679957	72341019	8854191	92	40509											
SMAD4	4089	broad.mit.edu	37	chr18	48603080	48603080	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaagctgcagcagctgccCaggcagcagccgtggcagga	10	3	14	14	1	0	0	0	0	0	0	0	1	0	1	2	3	7	7	2	3	1	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr18:48603080C>T	uc010xdp.1	+	11	1919	c.1381C>T	c.(1381-1383)CAG>TAG	p.Q461*	SMAD4_uc002lfb.3_Nonsense_Mutation_p.Q306*	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	461	Poly-Ala.|MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		AGCAGCTGCCCAGGCAGCAGC	0.468									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				12	23					0	0	0	0	T	48603080	T	T	48603080	4	4	220	1	0	0	0	0	0	1	0	0	14824	595	21	4	1419	4	SMAD4	18	48603080	Nonsense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08		48603080	29474168	93	40510											
DOT1L	84444	broad.mit.edu	37	chr19	2214510	2214510	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcagctggactgggccaCgctgtcgctggagaagctgt	6	8	16	11	2	0	1	0	0	0	1	1	3	0	2	1	3	3	6	1	3	1	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr19:2214510C>T	uc002lvb.3	+	19	1874	c.1838C>T	c.(1837-1839)ACG>ATG	p.T613M	DOT1L_uc002lvc.1_Translation_Start_Site|uc002lvd.1_RNA|DOT1L_uc002lve.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	613						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACTGGGCCACGCTGTCGCTG	0.647													14	25					0	0	0	0	T	2214510	T	T	2214510	3	4	220	1	0	0	0	0	1	0	0	0	4731	536	19	1	1912	1	DOT1L	19	2214510	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08		2214510	56914473	94	40511											
ANO8	57719	broad.mit.edu	37	chr19	17436103	17436103	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccagaatcatgctcccgccgGgcatggtgctctgcatggcg	6	8	13	14	3	2	1	1	0	1	1	3	1	3	1	3	3	3	4	3	3	1	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr19:17436103G>A	uc002ngf.2	-	17	2913	c.2754C>T	c.(2752-2754)GCC>GCT	p.A918A	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	918	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(3)	3						GCTCCCGCCGGGCATGGTGCT	0.697													15	32					0	0	0	0	A	17436103	A	A	17436103	2	1	220	1	0	0	0	0	0	0	0	1	703	1219	43	4		4	ANO8	19	17436103	Silent	SNP	G	TCGA-CV-7097-01A-11D-2012-08	15221593	17436103	41692880	95	40512											
ZNF708	7562	broad.mit.edu	37	chr19	21476934	21476934	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattcttcacatttgtagggTttctctccagtatgaactat	9	17	6	9	0	3	1	1	1	2	0	5	1	4	1	1	1	1	3	1	1	4	7			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr19:21476934T>G	uc002npq.1	-	4	1032	c.834A>C	c.(832-834)AAA>AAC	p.K278N	ZNF708_uc002npr.1_Missense_Mutation_p.K214N|ZNF708_uc010ecs.1_Missense_Mutation_p.K214N	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						ATTTGTAGGGTTTCTCTCCAG	0.373													23	54					0	0	0	0	G	21476934	G	G	21476934	3	3	220	1	0	0	0	0	1	0	0	0	18179	1722	60	5	861	5	ZNF708	19	21476934	Missense_Mutation	SNP	T	TCGA-CV-7097-01A-11D-2012-08	4040831	21476934	37652049	96	40513											
PAF1	54623	broad.mit.edu	37	chr19	39876966	39876966	+	Frame_Shift_Del	DEL	C	-	-																															ctcgtccctgtcaccttcctCccgttcactctcgctgcccg																										TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr19:39876966delC	uc002old.2	-	14	1436	c.1261delG	c.(1261-1263)GAGfs	p.E421fs	PAF1_uc002ole.1_Intron	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	421	Glu-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TCACCTTCCTCCCGTTCACTC	0.602													---	---	---								-	39876966	-	-	39876966	7	5	220	1	0	1	0	1	0	0	0	0	11437	864	30	0	338	0	PAF1	19	39876966	Frame_Shift_Del	DEL	C	TCGA-CV-7097-01A-11D-2012-08	18400032	39876966	19252017	97	40514											
ZNF224	7767	broad.mit.edu	37	chr19	44610697	44610697	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcagttctccaaagaaggTgatttcccctgccagactga	10	11	8	12	0	2	4	1	2	2	2	5	4	3	4	4	1	1	1	4	1	2	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr19:44610697T>A	uc002oyh.1	+	6	686	c.384T>A	c.(382-384)GGT>GGA	p.G128G	uc002oyi.2_RNA	NM_013398	NP_037530	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	128					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				CCAAAGAAGGTGATTTCCCCT	0.433													10	63					0	0	0	0	A	44610697	A	A	44610697	2	1	220	1	0	0	0	0	0	0	0	1	17845	1683	59	5		5	ZNF224	19	44610697	Silent	SNP	T	TCGA-CV-7097-01A-11D-2012-08	4733731	44610697	14518286	98	40515											
NAPA	8775	broad.mit.edu	37	chr19	47996389	47996390	+	Frame_Shift_Ins	INS	-	G	G																															ggctacctgttggactcctcINSgcctttgtagtagtctgcag																										TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr19:47996389_47996390insG	uc002pha.1	-	6	762_763	c.462_463insC	c.(460-465)GGCGAGfs	p.G154fs	uc002pgz.1_Intron|NAPA_uc002phb.1_Frame_Shift_Ins_p.G115fs|NAPA_uc002phc.1_Frame_Shift_Ins_p.G41fs|NAPA_uc002phd.1_Frame_Shift_Ins_p.G154fs|NAPA_uc010elf.1_Frame_Shift_Ins_p.A24fs	NM_003827	NP_003818	P54920	SNAA_HUMAN	N-ethylmaleimide-sensitive factor attachment	154_155					cellular membrane fusion|intra-Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport	cytosol					0		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000466)|all cancers(93;0.000739)|Epithelial(262;0.0168)|GBM - Glioblastoma multiforme(486;0.049)		TTGGACTCCTCGCCTTTGTAGT	0.649													---	---	---								G	47996390	G	G	47996389	7	5	220	1	0	1	1	0	0	0	0	0	10214	893	31	0	448	0	NAPA	19	47996389	Frame_Shift_Ins	INS	-	TCGA-CV-7097-01A-11D-2012-08	3385692	47996389	11132594	99	40516											
LILRB1	10859	broad.mit.edu	37	chr19	55144664	55144664	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggctgaattccccatgggtCctgtgacctcagcccatgcg	7	9	11	14	1	1	2	1	2	0	0	3	2	3	2	5	2	2	1	5	2	1	1			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr19:55144664C>T	uc002qgj.2	+	8	1496	c.1156C>T	c.(1156-1158)CCT>TCT	p.P386S	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.P386S|LILRB1_uc002qgk.2_Missense_Mutation_p.P386S|LILRB1_uc002qgm.2_Missense_Mutation_p.P386S|LILRB1_uc010erq.2_Missense_Mutation_p.P386S|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	386	Ig-like C2-type 4.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CCCCATGGGTCCTGTGACCTC	0.567										HNSCC(37;0.09)			32	105					0	0	0	0	T	55144664	T	T	55144664	3	4	220	1	0	0	0	0	1	0	0	0	8831	855	30	2	1178	2	LILRB1	19	55144664	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08	7148275	55144664	3984319	100	40517											
RIMS4	140730	broad.mit.edu	37	chr20	43386376	43386376	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggataatgtccacctccaacTgaccgttccgctcctgcaga	9	9	8	15	2	0	2	0	1	0	1	4	3	4	3	6	1	2	3	6	1	2	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr20:43386376T>A	uc002xms.2	-	4	386	c.386A>T	c.(385-387)CAG>CTG	p.Q129L	RIMS4_uc010ggu.2_Missense_Mutation_p.Q130L	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	129	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				CACCTCCAACTGACCGTTCCG	0.592													73	68					0	0	0	0	A	43386376	A	A	43386376	3	1	220	1	0	0	0	0	1	0	0	0	13435	1580	55	5	435	5	RIMS4	20	43386376	Missense_Mutation	SNP	T	TCGA-CV-7097-01A-11D-2012-08		43386376	19639144	101	40518											
RBPJL	11317	broad.mit.edu	37	chr20	43945404	43945404	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctggctgcgcgctcccatCacaatccccatgagcctggt	6	8	10	17	3	1	1	1	1	0	0	3	1	3	1	4	2	2	3	4	2	1	0			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr20:43945404C>A	uc002xns.2	+	12	1431	c.1359C>A	c.(1357-1359)ATC>ATA	p.I453I	RBPJL_uc002xnt.2_Missense_Mutation_p.H457N	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L	453	IPT/TIG.				signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GCGCTCCCATCACAATCCCCA	0.697													30	39					2.36697e-06	5.91743e-06	1	0	A	43945404	A	A	43945404	2	1	220	1	0	0	0	0	0	0	0	1	13227	816	29	2		2	RBPJL	20	43945404	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08	559028	43945404	19080116	102	40519											
DDX27	55661	broad.mit.edu	37	chr20	47855521	47855530	+	Frame_Shift_Del	DEL	ATGGAGAAAG	-	-																															tccgggacaagattgagaaaAtggagaaagatgtgtatgca																										TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr20:47855521_47855530delATGGAGAAAG	uc002xuh.2	+	15	1877_1886	c.1816_1825delATGGAGAAAG	c.(1816-1827)ATGGAGAAAGATfs	p.M606fs		NM_017895	NP_060365	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	606_609						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			kidney(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GATTGAGAAAATGGAGAAAGATGTGTATGC	0.405													---	---	---								-	47855530	-	-	47855521	7	5	220	1	0	1	0	1	0	0	0	0	4371	101	4	0	1874	0	DDX27	20	47855521	Frame_Shift_Del	DEL	ATGGAGAAAG	TCGA-CV-7097-01A-11D-2012-08	3910117	47855521	15169999	103	40520											
SLC17A9	63910	broad.mit.edu	37	chr20	61598792	61598792	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaacctggggctgtgcacCttcctggtgtttggacaggc	6	10	14	11	0	0	0	0	0	0	0	1	1	1	1	3	5	3	4	3	5	1	2			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr20:61598792C>A	uc002yea.3	+	13	1435	c.1251C>A	c.(1249-1251)ACC>ACA	p.T417T	SLC17A9_uc002ydz.3_Silent_p.T411T|SLC17A9_uc011aap.1_3'UTR	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	417	Helical; (Potential).				exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						GGCTGTGCACCTTCCTGGTGT	0.607													50	152					4.01344e-20	1.07138e-19	1	0	A	61598792	A	A	61598792	2	1	220	1	0	0	0	0	0	0	0	1	14489	668	24	4		4	SLC17A9	20	61598792	Silent	SNP	C	TCGA-CV-7097-01A-11D-2012-08	13743271	61598792	1426728	104	40521											
DONSON	29980	broad.mit.edu	37	chr21	34958441	34958441	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtccacaggtaactcagtaCtttttgaggacggaatatca	13	11	9	8	1	2	1	2	1	0	0	3	3	3	3	1	3	2	2	1	3	4	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr21:34958441C>T	uc002ysk.2	-	3	516	c.449G>A	c.(448-450)AGT>AAT	p.S150N	DONSON_uc002ysn.1_Missense_Mutation_p.S33N|DONSON_uc002ysi.1_5'UTR|DONSON_uc002ysj.2_5'UTR|DONSON_uc002ysl.2_Intron|DONSON_uc010gme.2_Missense_Mutation_p.S123N|DONSON_uc002ysm.2_Missense_Mutation_p.S150N	NM_017613	NP_060083	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	150					multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2						TAACTCAGTACTTTTTGAGGA	0.398											OREG0003565	type=REGULATORY REGION|Gene=DONSON|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	9	39					0	0	0	0	T	34958441	T	T	34958441	3	4	220	1	0	0	0	0	1	0	0	0	4728	565	20	4	1283	4	DONSON	21	34958441	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08		34958441	13171454	105	40522											
MCM3AP	8888	broad.mit.edu	37	chr21	47660924	47660924	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaggatgaaaaggctttaTtgccaaactgtaagtacatg	16	10	10	5	0	0	2	0	1	0	1	0	3	0	3	1	2	3	3	1	2	7	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chr21:47660924T>C	uc002zir.1	-	26	5470	c.5434A>G	c.(5434-5436)ATA>GTA	p.I1812V	MCM3APAS_uc002zim.2_RNA|MCM3APAS_uc002zin.2_Silent_p.Y115Y|MCM3AP_uc002zio.1_Missense_Mutation_p.I307V|MCM3AP_uc002zip.1_Missense_Mutation_p.I553V|MCM3AP_uc002ziq.1_Missense_Mutation_p.I739V|MCM3APAS_uc002zis.1_RNA	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	1812					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					AAAGGCTTTATTGCCAAACTG	0.388													46	86					0	0	0	0	C	47660924	C	C	47660924	3	2	220	1	0	0	0	0	1	0	0	0	9441	1493	52	5	520	5	MCM3AP	21	47660924	Missense_Mutation	SNP	T	TCGA-CV-7097-01A-11D-2012-08	12702483	47660924	468971	106	40523											
ZRSR2	8233	broad.mit.edu	37	chrX	15809058	15809058	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atatgtcttaatcttccagcCacaaaaagtacagggccgcc	13	9	7	12	1	2	0	0	0	2	0	3	0	3	0	4	1	2	1	4	1	5	4			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chrX:15809058C>A	uc004cxg.3	+	2	88	c.43C>A	c.(43-45)CAC>AAC	p.H15N		NM_005089	NP_005080	Q15696	U2AFM_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 2	15					spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)	3	Hepatocellular(33;0.183)					ATCTTCCAGCCACAAAAAGTA	0.512													12	18					3.07112e-06	7.61734e-06	1	0	A	15809058	A	A	15809058	3	1	220	1	0	0	0	0	1	0	0	0	18292	608	21	4	49	4	ZRSR2	23	15809058	Missense_Mutation	SNP	C	TCGA-CV-7097-01A-11D-2012-08		15809058	139461502	107	40524											
RGAG4	340526	broad.mit.edu	37	chrX	71350448	71350448	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagggagcgggataggctTgggaacgcgcacttttcttt	7	11	14	9	3	1	0	0	0	1	0	2	3	2	3	1	4	2	2	1	4	2	5			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chrX:71350448T>C	uc010nlh.1	-	1	1304	c.943A>G	c.(943-945)AAG>GAG	p.K315E	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	315								p.R315H(1)		ovary(2)|skin(1)	3	Renal(35;0.156)					GGGATAGGCTTGGGAACGCGC	0.468													3	87					0	0	0	0	C	71350448	C	C	71350448	3	2	220	1	0	0	0	0	1	0	0	0	13340	1821	63	5	770	5	RGAG4	23	71350448	Missense_Mutation	SNP	T	TCGA-CV-7097-01A-11D-2012-08	55541390	71350448	83920112	108	40525											
MAGEA3	4102	broad.mit.edu	37	chrX	151935540	151935540	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacagtcgccctctcttgcGattatggccaggacgattat	8	11	10	12	3	1	0	0	0	1	0	3	3	1	1	2	2	1	1	2	2	2	3			TCGA-CV-7097-01A-11D-2012-08	TCGA-CV-7097-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	23336d44-bb79-4361-b661-ce26eae06692	9f8bd5fe-ec7e-40e0-ba9d-063b2696aa1a	g.chrX:151935540G>A	uc004fgp.2	-	3	836	c.627C>T	c.(625-627)ATC>ATT	p.I209I		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	209	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCTCTTGCGATTATGGCCA	0.562													13	169					0	0	0	0	A	151935540	A	A	151935540	2	1	220	1	0	0	0	0	0	0	0	1	9218	1048	37	1		1	MAGEA3	23	151935540	Silent	SNP	G	TCGA-CV-7097-01A-11D-2012-08	80585092	151935540	3335020	109	40526											
NOC2L	26155	broad.mit.edu	37	chr1	886571	886571	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgagagcagcgtcagggcaCggatgcagtgcattcgcagc	9	5	15	12	4	1	1	1	0	0	1	2	3	1	2	1	2	5	5	1	2	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:886571C>A	uc001abz.3	-	12	1438	c.1379G>T	c.(1378-1380)CGT>CTT	p.R460L	NOC2L_uc001aby.3_Missense_Mutation_p.R257L|NOC2L_uc009vjq.2_Missense_Mutation_p.R460L	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	460						nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		CGTCAGGGCACGGATGCAGTG	0.687													3	6					0.004672	0.00646541	1	0	A	886571	A	A	886571	3	1	221	1	0	0	0	0	1	0	0	0	10567	536	19	3	902	3	NOC2L	1	886571	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08		886571	248364050	1	40527											
CCDC27	148870	broad.mit.edu	37	chr1	3683848	3683848	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcgggactgtgtcatctcaGagttggacaccaaggtcagc	10	8	13	10	1	3	1	3	0	1	1	4	3	3	3	1	3	2	1	1	3	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:3683848G>C	uc001akv.2	+	10	1663	c.1582G>C	c.(1582-1584)GAG>CAG	p.E528Q		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	528										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TGTCATCTCAGAGTTGGACAC	0.567													6	30					0	0	0	0	C	3683848	C	C	3683848	3	2	221	1	0	0	0	0	1	0	0	0	2814	943	33	2	1620	2	CCDC27	1	3683848	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	2797277	3683848	245566773	2	40528											
MTHFR	4524	broad.mit.edu	37	chr1	11851316	11851316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggtgggctggatgatctctCgcccagggaagatgccccaa	8	7	14	12	2	1	2	0	1	1	1	3	4	1	4	3	4	1	1	3	4	2	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:11851316C>T	uc001atc.1	-	11	1884	c.1700G>A	c.(1699-1701)CGA>CAA	p.R567Q	MTHFR_uc001atb.1_Missense_Mutation_p.R590Q	NM_005957	NP_005948	P42898	MTHR_HUMAN	5,10-methylenetetrahydrofolate reductase	567					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	GATGATCTCTCGCCCAGGGAA	0.602													18	30					0	0	0	0	T	11851316	T	T	11851316	3	4	221	1	0	0	0	0	1	0	0	0	9984	884	31	1	278	1	MTHFR	1	11851316	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	8167468	11851316	237399305	3	40529											
PRDM2	7799	broad.mit.edu	37	chr1	14108593	14108593	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagtacagaaagcaattcttCagaaaaacaaatctgcaaag	20	8	6	7	0	3	2	1	0	2	2	3	2	3	2	0	0	4	3	0	0	8	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:14108593C>T	uc001avi.2	+	8	5159	c.4303C>T	c.(4303-4305)CAG>TAG	p.Q1435*	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Nonsense_Mutation_p.Q1435*|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Nonsense_Mutation_p.Q1234*|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1435	Arg/Lys-rich (basic).					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		AGCAATTCTTCAGAAAAACAA	0.378													65	139					0	0	0	0	T	14108593	T	T	14108593	4	4	221	1	0	0	0	0	0	1	0	0	12520	827	29	2	4329	2	PRDM2	1	14108593	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2257277	14108593	235142028	4	40530			1	64		3	3	413	C		1.042307e-05
PRDM2	7799	broad.mit.edu	37	chr1	14108975	14108975	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaacgtcaagtttgcagcttCggtgaaatccaaaaaaccaa	16	8	8	9	2	1	1	1	1	0	0	3	2	2	1	2	1	4	3	2	1	7	2	rs61747666		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:14108975C>T	uc001avi.2	+	8	5541	c.4685C>T	c.(4684-4686)TCG>TTG	p.S1562L	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.S1562L|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Missense_Mutation_p.S1361L|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1562						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		TTTGCAGCTTCGGTGAAATCC	0.512													23	61					0	0	0	0	T	14108975	T	T	14108975	3	4	221	1	0	0	0	0	1	0	0	0	12520	893	31	1	4711	1	PRDM2	1	14108975	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	382	14108975	235141646	5	40531			1	64		3	3	413	C		1.042307e-05
PRDM2	7799	broad.mit.edu	37	chr1	14109005	14109005	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaaaaccaagctcctcctCtttaaggaactccagcccga	14	7	5	15	1	1	0	0	0	1	0	4	2	4	1	5	1	4	1	5	1	6	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:14109005C>G	uc001avi.2	+	8	5571	c.4715C>G	c.(4714-4716)TCT>TGT	p.S1572C	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.S1572C|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Missense_Mutation_p.S1371C|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1572						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		AGCTCCTCCTCTTTAAGGAAC	0.488													20	51					0	0	0	0	G	14109005	G	G	14109005	3	3	221	1	0	0	0	0	1	0	0	0	12520	913	32	2	4741	2	PRDM2	1	14109005	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	30	14109005	235141616	6	40532			1	64		3	3	413	C		1.042307e-05
UBR4	23352	broad.mit.edu	37	chr1	19505574	19505574	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttaaggcattctgggacGtcagggtcaccttgagcact	9	11	11	10	1	3	1	2	1	1	0	3	2	3	2	1	3	1	2	1	3	1	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:19505574G>A	uc001bbi.2	-	18	2329	c.2325C>T	c.(2323-2325)GAC>GAT	p.D775D	UBR4_uc001bbm.1_Translation_Start_Site	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	775					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ATTCTGGGACGTCAGGGTCAC	0.458													13	170					0	0	0	0	A	19505574	A	A	19505574	2	1	221	1	0	0	0	0	0	0	0	1	16972	1136	40	1		1	UBR4	1	19505574	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	5396569	19505574	229745047	7	40533											
SH2D5	400745	broad.mit.edu	37	chr1	21050978	21050978	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgatcacggccgaagggctCccgcaccaggcccccagagc	8	3	12	18	3	1	2	1	1	0	1	2	3	2	2	5	3	1	2	5	3	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:21050978C>T	uc001bdt.1	-	5	914	c.289G>A	c.(289-291)GAG>AAG	p.E97K	SH2D5_uc009vpy.1_Missense_Mutation_p.E181K|SH2D5_uc001bdu.1_RNA	NM_001103160	NP_001096630	Q6ZV89	SH2D5_HUMAN	SH2 domain containing 5 isoform 2	97											0		Colorectal(325;3.46e-05)|all_lung(284;5.32e-05)|Lung NSC(340;5.51e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|GBM - Glioblastoma multiforme(114;0.000465)|Kidney(64;0.000476)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(64;0.00634)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCGAAGGGCTCCCGCACCAGG	0.692													7	15					0	0	0	0	T	21050978	T	T	21050978	3	4	221	1	0	0	0	0	1	0	0	0	14302	864	30	2	750	2	SH2D5	1	21050978	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1545404	21050978	228199643	8	40534											
EPHA8	2046	broad.mit.edu	37	chr1	22927210	22927212	+	In_Frame_Del	DEL	CTC	-	-																															gccatcgccttccgcaccttCtcctcggccagcgacgtgtg																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:22927210_22927212delCTC	uc001bfx.1	+	14	2570_2572	c.2445_2447delCTC	c.(2443-2448)TTCTCC>TTC	p.S817del		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	817	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCCGCACCTTCTCCTCGGCCAGC	0.665													---	---	---								-	22927212	-	-	22927210	7	5	221	1	0	1	0	1	0	0	0	0	5197	912	32	0	2672	0	EPHA8	1	22927210	In_Frame_Del	DEL	CTC	TCGA-CV-7099-01A-41D-2012-08	1876232	22927210	226323411	9	40535											
SFN	2810	broad.mit.edu	37	chr1	27190444	27190444	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggctccccaggagccccaGagctgagtgttgcccgccac	7	5	13	16	1	0	2	0	1	0	1	1	4	1	3	6	2	3	3	6	2	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:27190444G>C	uc001bnc.1	+	1	812	c.741G>C	c.(739-741)CAG>CAC	p.Q247H	uc010ofi.1_RNA	NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	247					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		AGGAGCCCCAGAGCTGAGTGT	0.687													7	21					0	0	0	0	C	27190444	C	C	27190444	3	2	221	1	0	0	0	0	1	0	0	0	14224	933	33	2	743	2	SFN	1	27190444	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4263234	27190444	222060177	10	40536											
COL16A1	1307	broad.mit.edu	37	chr1	32134424	32134424	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctcccccttgtctccagtCaggcccgtgagacctcgctc	4	9	10	18	2	2	1	1	1	1	1	6	2	3	1	5	2	0	2	5	2	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:32134424C>T	uc001btk.1	-	50	3593	c.3228G>A	c.(3226-3228)CTG>CTA	p.L1076L	COL16A1_uc001bti.1_5'UTR|COL16A1_uc001btj.1_Silent_p.L874L	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	1076	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TGTCTCCAGTCAGGCCCGTGA	0.617													22	37					0	0	0	0	T	32134424	T	T	32134424	2	4	221	1	0	0	0	0	0	0	0	1	3688	813	29	2		2	COL16A1	1	32134424	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	4943980	32134424	217116197	11	40537											
KIAA1522	57648	broad.mit.edu	37	chr1	33237233	33237233	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtcagctccccggctgcttCgtcctcctcagctactgctt	3	13	8	17	2	2	0	2	0	0	0	6	0	5	0	4	1	5	5	4	1	1	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:33237233C>T	uc001bvv.2	+	6	2412	c.2276C>T	c.(2275-2277)TCG>TTG	p.S759L	KIAA1522_uc001bvu.1_Missense_Mutation_p.S818L|KIAA1522_uc010ohm.1_Missense_Mutation_p.S770L|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	759	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCGGCTGCTTCGTCCTCCTCA	0.652													19	42					0	0	0	0	T	33237233	T	T	33237233	3	4	221	1	0	0	0	0	1	0	0	0	8277	893	31	1	2475	1	KIAA1522	1	33237233	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1102809	33237233	216013388	12	40538											
CTPS	1503	broad.mit.edu	37	chr1	41454371	41454371	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgtaacatccacgtcagtCtagttccccaggtaagtaag	11	12	8	10	1	2	0	1	0	1	0	4	0	4	0	3	1	1	4	3	1	4	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:41454371C>G	uc001cgk.3	+	5	1052	c.544C>G	c.(544-546)CTA>GTA	p.L182V	CTPS_uc010ojo.1_Intron|CTPS_uc010ojp.1_Missense_Mutation_p.L189V|CTPS_uc001cgl.3_Missense_Mutation_p.L182V|CTPS_uc010ojq.1_Missense_Mutation_p.L26V	NM_001905	NP_001896	P17812	PYRG1_HUMAN	CTP synthase	182					CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)			L-Glutamine(DB00130)	CCACGTCAGTCTAGTTCCCCA	0.443													5	64					0	0	0	0	G	41454371	G	G	41454371	3	3	221	1	0	0	0	0	1	0	0	0	4039	912	32	2	558	2	CTPS	1	41454371	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	8217138	41454371	207796250	13	40539											
CCDC30	728621	broad.mit.edu	37	chr1	43047055	43047055	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggacctgcagcggaaattaGaacatgctcataaagtctgt	13	10	10	8	1	2	1	1	0	1	1	2	3	2	3	1	2	4	2	1	2	5	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:43047055G>C	uc009vwk.1	+	8	1200	c.1090G>C	c.(1090-1092)GAA>CAA	p.E364Q	CCDC30_uc001chm.2_Missense_Mutation_p.E62Q|CCDC30_uc001chn.2_Missense_Mutation_p.E153Q|CCDC30_uc010oju.1_RNA|CCDC30_uc001chp.2_Missense_Mutation_p.E178Q	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	364	Potential.										0						GCGGAAATTAGAACATGCTCA	0.338													17	71					0	0	0	0	C	43047055	C	C	43047055	3	2	221	1	0	0	0	0	1	0	0	0	2818	943	33	2	1116	2	CCDC30	1	43047055	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1592684	43047055	206203566	14	40540											
ZSWIM5	57643	broad.mit.edu	37	chr1	45485782	45485782	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accatcgtaccatctccctgCgtctccagttaagggttgat	8	12	8	13	2	2	1	0	1	2	0	5	1	2	1	4	1	2	3	4	1	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:45485782C>T	uc001cnd.2	-	13	2879	c.2651G>A	c.(2650-2652)CGC>CAC	p.R884H		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	884							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					CATCTCCCTGCGTCTCCAGTT	0.552													9	25					0	0	0	0	T	45485782	T	T	45485782	3	4	221	1	0	0	0	0	1	0	0	0	18311	768	27	1	914	1	ZSWIM5	1	45485782	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2438727	45485782	203764839	15	40541											
GBP1	2633	broad.mit.edu	37	chr1	89521738	89521738	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctcatagtactttttcttCaggtcttgtagcttctgaac	7	18	6	10	0	5	1	2	1	3	0	6	1	6	1	1	1	3	3	1	1	4	8			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:89521738C>T	uc001dmx.2	-	8	1549	c.1329G>A	c.(1327-1329)CTG>CTA	p.L443L		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	443					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		ACTTTTTCTTCAGGTCTTGTA	0.438													77	186					0	0	0	0	T	89521738	T	T	89521738	2	4	221	1	0	0	0	0	0	0	0	1	6308	813	29	2		2	GBP1	1	89521738	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	44035956	89521738	159728883	16	40542											
BTBD8	284697	broad.mit.edu	37	chr1	92613302	92613302	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctttgcaaatatacctcctGagattcagaaaagttgtctt	12	14	7	8	0	2	2	1	1	1	2	3	3	3	2	2	0	2	3	2	0	5	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:92613302G>C	uc001doo.2	+	9	1348	c.1081G>C	c.(1081-1083)GAG>CAG	p.E361Q	BTBD8_uc010otc.1_RNA	NM_183242	NP_899065	Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	361						nucleus				ovary(1)	1		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		TATACCTCCTGAGATTCAGAA	0.308													15	20					0	0	0	0	C	92613302	C	C	92613302	3	2	221	1	0	0	0	0	1	0	0	0	1552	1291	45	2	1115	2	BTBD8	1	92613302	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	3091564	92613302	156637319	17	40543											
CCDC76	54482	broad.mit.edu	37	chr1	100608709	100608709	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggtggatggaaaacacaGaaagaaaaattcagtgtttg	17	8	12	4	0	1	2	1	0	0	2	1	4	1	4	0	3	1	2	0	3	5	2	rs147022991		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:100608709G>A	uc001dsv.2	+	8	705	c.686G>A	c.(685-687)AGA>AAA	p.R229K	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Missense_Mutation_p.R229K	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	229					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		GGAAAACACAGAAAGAAAAAT	0.274													5	25					0	0	0	0	A	100608709	A	A	100608709	3	1	221	1	0	0	0	0	1	0	0	0	2863	942	33	2	716	2	CCDC76	1	100608709	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	7995407	100608709	148641912	18	40544											
AP4B1	10717	broad.mit.edu	37	chr1	114442970	114442970	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcactgcggggttggtagcGtagcagaaagttcaatactt	10	11	12	8	2	2	1	2	0	0	1	2	1	2	1	0	3	4	5	0	3	5	6	rs138216814		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:114442970G>A	uc001eeb.2	-	5	813	c.670C>T	c.(670-672)CGC>TGC	p.R224C	uc001edv.1_RNA|AP4B1_uc001eec.2_Missense_Mutation_p.R56C|AP4B1_uc001eed.2_Missense_Mutation_p.R224C|AP4B1_uc010owp.1_Missense_Mutation_p.R125C|AP4B1_uc001eea.1_Missense_Mutation_p.R18C|AP4B1_uc010owq.1_Missense_Mutation_p.R131C	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	224					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGTTGGTAGCGTAGCAGAAAG	0.428													14	39					0	0	0	0	A	114442970	A	A	114442970	3	1	221	1	0	0	0	0	1	0	0	0	751	1145	40	1	1573	1	AP4B1	1	114442970	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	13834261	114442970	134807651	19	40545											
DENND2C	163259	broad.mit.edu	37	chr1	115153710	115153710	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcactctttggcagatactcGgcatcactttcgttcccact	7	14	6	14	2	3	1	2	0	1	1	6	1	4	1	1	2	1	3	1	2	1	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:115153710G>C	uc001efd.1	-	9	2055	c.1353C>G	c.(1351-1353)GCC>GCG	p.A451A	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Silent_p.A394A	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	451										skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCAGATACTCGGCATCACTTT	0.458													5	75					0	0	0	0	C	115153710	C	C	115153710	2	2	221	1	0	0	0	0	0	0	0	1	4452	1103	39	3		3	DENND2C	1	115153710	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	710740	115153710	134096911	20	40546											
ACP6	51205	broad.mit.edu	37	chr1	147131131	147131131	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgggtggactccagattcCgaaaaatgttagtggaacga	14	8	12	7	3	0	1	0	0	0	1	2	5	2	3	2	3	2	1	2	3	5	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:147131131C>T	uc001epr.2	-	4	967	c.503G>A	c.(502-504)CGG>CAG	p.R168Q	ACP6_uc009wjj.1_Missense_Mutation_p.R125Q	NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	168					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					CTCCAGATTCCGAAAAATGTT	0.413													33	76					0	0	0	0	T	147131131	T	T	147131131	3	4	221	1	0	0	0	0	1	0	0	0	165	652	23	1	811	1	ACP6	1	147131131	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	31977421	147131131	102119490	21	40547											
MTMR11	10903	broad.mit.edu	37	chr1	149905304	149905305	+	Missense_Mutation	DNP	AG	TT	TT																															aaaggttattctcaccaggcAggcagagggccctcagcctc																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:149905304_149905305AG>TT	uc001etl.3	-	10	1230_1231	c.979_980CT>AA	c.(979-981)CTG>AAG	p.L327K	MTMR11_uc001etm.1_Missense_Mutation_p.L255K|MTMR11_uc010pbm.1_Missense_Mutation_p.L299K|MTMR11_uc010pbn.1_Missense_Mutation_p.L169K	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	327	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CTCACCAGGCAGGCAGAGGGCC	0.559													36	101					0	0	0	0	TT	149905305	TT	TT	149905304	3	4	221	1	0	0	0	0	1	0	0	0	9993	188	7	5	1220	5	MTMR11	1	149905304	Missense_Mutation	DNP	AG	TCGA-CV-7099-01A-41D-2012-08	2774173	149905304	99345317	22	40548											
FLG	2312	broad.mit.edu	37	chr1	152282919	152282919	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcctgaccgtcttgggaTgctgagtgcctagagctgtt	5	13	14	9	1	1	3	0	2	1	1	2	4	2	4	3	1	3	3	3	1	1	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:152282919T>C	uc001ezu.1	-	3	4479	c.4443A>G	c.(4441-4443)GCA>GCG	p.A1481A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1481	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGTCTTGGGATGCTGAGTGCC	0.567									Ichthyosis				16	356					0	0	0	0	C	152282919	C	C	152282919	2	2	221	1	0	0	0	0	0	0	0	1	5954	1451	51	5		5	FLG	1	152282919	Silent	SNP	T	TCGA-CV-7099-01A-41D-2012-08	2377615	152282919	96967702	23	40549											
FLG	2312	broad.mit.edu	37	chr1	152282956	152282956	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttcgtgcctgctcatggCgggatccttgtcttcctcca	3	15	10	13	2	2	0	1	0	1	0	6	1	5	1	4	2	2	2	4	2	0	3	rs145675213	byFrequency	TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:152282956C>T	uc001ezu.1	-	3	4442	c.4406G>A	c.(4405-4407)CGC>CAC	p.R1469H	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1469	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCTCATGGCGGGATCCTTG	0.577									Ichthyosis				24	255					0	0	0	0	T	152282956	T	T	152282956	3	4	221	1	0	0	0	0	1	0	0	0	5954	768	27	1	7783	1	FLG	1	152282956	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	37	152282956	96967665	24	40550											
UBE2Q1	55585	broad.mit.edu	37	chr1	154523963	154523963	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tctatggagtaggcactgctCcagccctgggtgaagggaag	9	8	15	9	0	1	1	0	1	1	0	2	3	2	3	2	4	2	3	2	4	4	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:154523963C>G	uc001fff.1	-	11	1171	c.1080G>C	c.(1078-1080)TGG>TGC	p.W360C		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	360							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGGCACTGCTCCAGCCCTGGG	0.537													42	65					0	0	0	0	G	154523963	G	G	154523963	3	3	221	1	0	0	0	0	1	0	0	0	16937	856	30	2	200	2	UBE2Q1	1	154523963	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2241007	154523963	94726658	25	40551											
KIAA0907	22889	broad.mit.edu	37	chr1	155887369	155887369	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgtgcctggggctgacttGggagtgggggctggggctgg	2	10	22	7	0	1	1	0	1	1	0	1	2	1	2	1	8	1	3	1	8	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:155887369G>C	uc001fmi.1	-	11	1385	c.1361C>G	c.(1360-1362)CCA>CGA	p.P454R	KIAA0907_uc001fmj.1_Missense_Mutation_p.P454R|KIAA0907_uc009wrk.1_Missense_Mutation_p.P311R|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	454	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			GGGCTGACTTGGGAGTGgggg	0.443													25	41					0	0	0	0	C	155887369	C	C	155887369	3	2	221	1	0	0	0	0	1	0	0	0	8238	1348	47	4	499	4	KIAA0907	1	155887369	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1363406	155887369	93363252	26	40552											
OR10X1	128367	broad.mit.edu	37	chr1	158548948	158548948	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaggccttctgcttgccctCagctgaagggatcctgagga	8	9	13	11	0	2	2	1	2	1	0	3	5	3	4	3	3	3	2	3	3	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:158548948C>T	uc010pin.1	-	1	742	c.742G>A	c.(742-744)GAG>AAG	p.E248K		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	248	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TGCTTGCCCTCAGCTGAAGGG	0.473													41	81					0	0	0	0	T	158548948	T	T	158548948	3	4	221	1	0	0	0	0	1	0	0	0	10976	835	29	2	233	2	OR10X1	1	158548948	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2661579	158548948	90701673	27	40553											
ATP1A4	480	broad.mit.edu	37	chr1	160156138	160156138	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgaaatcagaaaactcctCatccgtcagcacccggatgg	13	7	9	12	2	3	2	3	1	0	1	5	4	5	3	3	2	2	1	3	2	3	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:160156138C>T	uc001fve.3	+	21	3521	c.3042C>T	c.(3040-3042)CTC>CTT	p.L1014L	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Silent_p.L517L|ATP1A4_uc001fvh.2_Silent_p.L150L	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	1014	Cytoplasmic (Potential).			ITWWLCAIPYSILIFVYDEIRKLLIRQ -> WSFALTAQAG VKWRILGLLQPLPPRFK (in Ref. 6; BAC05228).	ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GAAAACTCCTCATCCGTCAGC	0.562													38	123					0	0	0	0	T	160156138	T	T	160156138	2	4	221	1	0	0	0	0	0	0	0	1	1133	813	29	2		2	ATP1A4	1	160156138	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1607190	160156138	89094483	28	40554											
COPA	1314	broad.mit.edu	37	chr1	160275281	160275281	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagataaataccccactctCatcccaggccccactcttga	12	9	4	16	0	2	2	1	1	2	1	4	2	3	2	5	1	1	0	5	1	4	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:160275281C>T	uc009wti.2	-	17	2003	c.1609G>A	c.(1609-1611)GAG>AAG	p.E537K	COPA_uc001fvv.3_Missense_Mutation_p.E546K|COPA_uc009wtj.1_Missense_Mutation_p.E483K	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	537					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACCCCACTCTCATCCCAGGCC	0.438													7	124					0	0	0	0	T	160275281	T	T	160275281	3	4	221	1	0	0	0	0	1	0	0	0	3742	835	29	2	2133	2	COPA	1	160275281	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	119143	160275281	88975340	29	40555											
RCSD1	92241	broad.mit.edu	37	chr1	167666869	167666872	+	Frame_Shift_Del	DEL	AAAG	-	-																															gaacatgacagccaagaaacAaagaagctggaggagggagc																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:167666869_167666872delAAAG	uc001gem.2	+	6	1195_1198	c.1008_1011delAAAG	c.(1006-1011)ACAAAGfs	p.T336fs	RCSD1_uc010pli.1_Frame_Shift_Del_p.T306fs	NM_052862	NP_443094	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	336_337										ovary(2)|central_nervous_system(2)|skin(1)	5	all_hematologic(923;0.215)					GCCAAGAAACAAAGAAGCTGGAGG	0.554													---	---	---								-	167666872	-	-	167666869	7	5	221	1	0	1	0	1	0	0	0	0	13250	117	5	0	1030	0	RCSD1	1	167666869	Frame_Shift_Del	DEL	AAAG	TCGA-CV-7099-01A-41D-2012-08	7391588	167666869	81583752	30	40556											
NPHS2	7827	broad.mit.edu	37	chr1	179533893	179533893	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggaaatgaggacaagaaGccactcacaggcccctaagc	15	3	11	12	0	1	2	1	1	0	1	1	4	1	4	3	3	2	0	3	3	4	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:179533893G>T	uc001gmq.3	-	2	395	c.310C>A	c.(310-312)CTT>ATT	p.L104I	NPHS2_uc009wxi.2_Missense_Mutation_p.L104I	NM_014625	NP_055440	Q9NP85	PODO_HUMAN	podocin	104					excretion	integral to plasma membrane	protein binding				0						AGGACAAGAAGCCACTCACAG	0.398													13	28					6.31663e-08	9.02831e-08	1	0	T	179533893	T	T	179533893	3	4	221	1	0	0	0	0	1	0	0	0	10637	971	34	4	869	4	NPHS2	1	179533893	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	11867024	179533893	69716728	31	40557											
CEP350	9857	broad.mit.edu	37	chr1	180012229	180012229	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actcatatctcagatgctgtCgtggcttcaggagctcccct	7	12	9	13	1	3	1	3	0	1	1	6	2	4	2	2	2	2	3	2	2	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:180012229C>T	uc001gnt.2	+	20	4784	c.4401C>T	c.(4399-4401)GTC>GTT	p.V1467V	CEP350_uc009wxl.2_Silent_p.V1466V	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1467						centrosome|nucleus|spindle				ovary(4)	4						CAGATGCTGTCGTGGCTTCAG	0.418													41	87					0	0	0	0	T	180012229	T	T	180012229	2	4	221	1	0	0	0	0	0	0	0	1	3269	871	31	1		1	CEP350	1	180012229	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	478336	180012229	69238392	32	40558											
XPR1	9213	broad.mit.edu	37	chr1	180601389	180601389	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcactcccgagtggaggaagCaatacatccagtatgaggta	13	8	11	9	1	1	1	1	1	0	0	3	4	3	3	2	3	2	3	2	3	5	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:180601389C>G	uc001goi.2	+	1	244	c.52C>G	c.(52-54)CAA>GAA	p.Q18E	XPR1_uc009wxm.2_Missense_Mutation_p.Q18E|XPR1_uc009wxn.2_Missense_Mutation_p.Q18E	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	18	SPX.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						GTGGAGGAAGCAATACATCCA	0.647													5	4					0	0	0	0	G	180601389	G	G	180601389	3	3	221	1	0	0	0	0	1	0	0	0	17519	711	25	4	54	4	XPR1	1	180601389	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	589160	180601389	68649232	33	40559											
IGFN1	91156	broad.mit.edu	37	chr1	201190818	201190818	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggtgacagcagttaatgaagGaggccagagccagcccagtg	12	5	15	9	0	0	3	0	2	0	1	0	4	0	4	3	3	3	2	3	3	2	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:201190818G>T	uc001gwc.2	+	8	2397	c.1625G>T	c.(1624-1626)GGA>GTA	p.G542V	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						GTTAATGAAGGAGGCCAGAGC	0.637													23	32					2.48779e-11	3.61049e-11	1	0	T	201190818	T	T	201190818	3	4	221	1	0	0	0	0	1	0	0	0	7629	1174	41	2	10215	2	IGFN1	1	201190818	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	20589429	201190818	48059803	34	40560											
NUAK2	81788	broad.mit.edu	37	chr1	205290541	205290541	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaccaggcgccccgagctCtcccgcgccttcttcacctt	4	9	7	21	4	4	0	2	0	2	0	5	1	4	0	6	1	1	1	6	1	0	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:205290541C>G	uc001hce.2	-	1	343	c.216G>C	c.(214-216)GAG>GAC	p.E72D		NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	72	Protein kinase.				actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCCCCGAGCTCTCCCGCGCCT	0.731													19	40					0	0	0	0	G	205290541	G	G	205290541	3	3	221	1	0	0	0	0	1	0	0	0	10767	912	32	2	1698	2	NUAK2	1	205290541	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	4099723	205290541	43960080	35	40561											
FAIM3	9214	broad.mit.edu	37	chr1	207085264	207085264	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggggaggagtggtgaactGgagggaccttgcccctttga	7	9	18	7	0	0	2	0	2	0	0	0	6	0	6	3	6	2	0	3	6	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:207085264G>A	uc001hey.2	-	4	700	c.521C>T	c.(520-522)CCA>CTA	p.P174L	FAIM3_uc010prz.1_Missense_Mutation_p.P62L|FAIM3_uc010psa.1_Missense_Mutation_p.P83L|FAIM3_uc010psb.1_Missense_Mutation_p.P174L	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	174	Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					GTGGTGAACTGGAGGGACCTT	0.473											OREG0014185	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	25					0	0	0	0	A	207085264	A	A	207085264	3	1	221	1	0	0	0	0	1	0	0	0	5405	1348	47	4	671	4	FAIM3	1	207085264	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1794723	207085264	42165357	36	40562											
PLXNA2	5362	broad.mit.edu	37	chr1	208257734	208257734	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgttttcttaccgagctgttCtgacactgaacgctggagct	7	13	10	11	3	2	2	0	2	2	0	2	4	2	3	1	1	4	5	1	1	2	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:208257734C>T	uc001hgz.2	-	10	3047	c.2289G>A	c.(2287-2289)CAG>CAA	p.Q763Q		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	763	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CCGAGCTGTTCTGACACTGAA	0.627													19	42					0	0	0	0	T	208257734	T	T	208257734	2	4	221	1	0	0	0	0	0	0	0	1	12175	912	32	2		2	PLXNA2	1	208257734	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1172470	208257734	40992887	37	40563											
RRP15	51018	broad.mit.edu	37	chr1	218504373	218504373	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatctatgaaagactgggaCaaggaaagtgatgggccaga	15	6	14	6	0	1	4	0	2	1	2	1	6	1	6	1	3	0	1	1	3	4	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:218504373C>A	uc001hlj.2	+	5	819	c.789C>A	c.(787-789)GAC>GAA	p.D263E	RRP15_uc001hlk.2_RNA	NM_016052	NP_057136	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog	263						mitochondrion|nucleolus	protein binding				0				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		AAGACTGGGACAAGGAAAGTG	0.408													8	18					1.12685e-05	1.60251e-05	1	0	A	218504373	A	A	218504373	3	1	221	1	0	0	0	0	1	0	0	0	13752	477	17	4	807	4	RRP15	1	218504373	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	10246639	218504373	30746248	38	40564											
OR2T11	127077	broad.mit.edu	37	chr1	248789544	248789544	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatacctttttaaatgcccCtatgacgtccttgtttctga	10	16	5	10	1	1	2	0	2	1	0	2	2	2	2	4	0	2	1	4	0	5	7			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:248789544C>T	uc001ier.1	-	1	886	c.886G>A	c.(886-888)GGG>AGG	p.G296R		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTAAATGCCCCTATGACGTCC	0.473													24	58					0	0	0	0	T	248789544	T	T	248789544	3	4	221	1	0	0	0	0	1	0	0	0	11072	681	24	4	68	4	OR2T11	1	248789544	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	30285171	248789544	461077	39	40565											
OR2T27	403239	broad.mit.edu	37	chr1	248813997	248813997	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccctgagggagagctggctGagcaggaagtacatgggggt	9	7	18	7	0	0	3	0	2	0	1	1	5	1	4	1	5	3	4	1	5	2	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr1:248813997G>A	uc010pzo.1	-	1	189	c.189C>T	c.(187-189)CTC>CTT	p.L63L		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGAGCTGGCTGAGCAGGAAGT	0.517													6	46					0	0	0	0	A	248813997	A	A	248813997	2	1	221	1	0	0	0	0	0	0	0	1	11075	1277	45	2		2	OR2T27	1	248813997	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	24453	248813997	436624	40	40566											
KIF3C	3797	broad.mit.edu	37	chr2	26204430	26204430	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctcaaaggcattcgggatGaccccgcgcagctcgggctc	7	7	13	14	4	1	1	1	1	0	0	4	2	1	2	2	3	2	5	2	3	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:26204430G>C	uc002rgu.2	-	1	1014	c.357C>G	c.(355-357)GTC>GTG	p.V119V	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Silent_p.V119V	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	119	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATTCGGGATGACCCCGCGCA	0.587													23	65					0	0	0	0	C	26204430	C	C	26204430	2	2	221	1	0	0	0	0	0	0	0	1	8341	1277	45	2		2	KIF3C	2	26204430	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08		26204430	216994943	41	40567											
C2orf16	84226	broad.mit.edu	37	chr2	27804899	27804899	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgtcacagtctcttggagagGagccatcgcagtccctctga	8	9	11	13	2	3	2	1	1	2	1	6	4	4	3	2	2	1	1	2	2	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:27804899G>C	uc002rkz.3	+	1	5511	c.5460G>C	c.(5458-5460)AGG>AGC	p.R1820S	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1820	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					TCTTGGAGAGGAGCCATCGCA	0.542													38	93					0	0	0	0	C	27804899	C	C	27804899	3	2	221	1	0	0	0	0	1	0	0	0	2167	1165	41	2	5462	2	C2orf16	2	27804899	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1600469	27804899	215394474	42	40568											
FOSL2	2355	broad.mit.edu	37	chr2	28634937	28634938	+	Frame_Shift_Ins	INS	-	CCAG	CCAG																															ccgaggagcgccgatcgcccINSccagcccctgggctgcagcc																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:28634937_28634938insCCAG	uc002rma.2	+	4	1412_1413	c.603_604insCCAG	c.(601-606)CCCCCAfs	p.P201fs	FOSL2_uc010ymi.1_Frame_Shift_Ins_p.P162fs	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	201_202					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					GCCGATCGCCCCCAGCCCCTGG	0.644													---	---	---								CCAG	28634938	CCAG	CCAG	28634937	7	5	221	1	0	1	1	0	0	0	0	0	6020	610	22	0	617	0	FOSL2	2	28634937	Frame_Shift_Ins	INS	-	TCGA-CV-7099-01A-41D-2012-08	830038	28634937	214564436	43	40569											
BIRC6	57448	broad.mit.edu	37	chr2	32667175	32667175	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttttcagaatttcatgaGaagcttgttaatactctttg	11	17	7	6	0	3	2	2	1	1	2	3	3	3	2	0	0	2	3	0	0	4	7			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:32667175G>A	uc010ezu.2	+	18	4121	c.3987G>A	c.(3985-3987)GAG>GAA	p.E1329E		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1329					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					AATTTCATGAGAAGCTTGTTA	0.378													16	59					0	0	0	0	A	32667175	A	A	32667175	2	1	221	1	0	0	0	0	0	0	0	1	1441	933	33	2		2	BIRC6	2	32667175	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4032238	32667175	210532198	44	40570											
SFRS7	6432	broad.mit.edu	37	chr2	38977291	38977291	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgaaagccctttctaactctCctttgccagcgccagttccc	7	12	6	16	1	2	1	0	1	2	0	4	1	3	1	5	0	4	1	5	0	2	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:38977291C>G	uc002rqz.2	-	2	312	c.74G>C	c.(73-75)GGA>GCA	p.G25A	SFRS7_uc002rra.2_RNA|SFRS7_uc010ynp.1_Missense_Mutation_p.G25A|GEMIN6_uc002rrb.2_5'Flank	NM_001031684	NP_001026854	Q16629	SRSF7_HUMAN	splicing factor, arginine/serine-rich 7	25	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding|zinc ion binding				0		all_hematologic(82;0.248)				TTCTAACTCTCCTTTGCCAGC	0.423													6	72					0	0	0	0	G	38977291	G	G	38977291	3	3	221	1	0	0	0	0	1	0	0	0	14247	855	30	2	670	2	SFRS7	2	38977291	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	6310116	38977291	204222082	45	40571											
MCFD2	90411	broad.mit.edu	37	chr2	47136232	47136232	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagctggctgcaggctcctCagccctggcgcctggggcac	5	6	15	15	1	1	0	1	0	0	0	2	1	2	0	3	5	3	5	3	5	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:47136232C>T	uc002rvk.2	-	2	173	c.79G>A	c.(79-81)GAG>AAG	p.E27K	MCFD2_uc002rvl.2_Intron|MCFD2_uc010fba.2_Missense_Mutation_p.E25K|MCFD2_uc010yof.1_Intron	NM_139279	NP_644808	Q8NI22	MCFD2_HUMAN	multiple coagulation factor deficiency 2	27					post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|vesicle-mediated transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	calcium ion binding			central_nervous_system(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)		Antihemophilic Factor(DB00025)	GCAGGCTCCTCAGCCCTGGCG	0.592													13	40					0	0	0	0	T	47136232	T	T	47136232	3	4	221	1	0	0	0	0	1	0	0	0	9434	835	29	2	373	2	MCFD2	2	47136232	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	8158941	47136232	196063141	46	40572											
SPTBN1	6711	broad.mit.edu	37	chr2	54856684	54856684	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacccttgacacgctgcacGaacaagccagcgccctcccc	9	4	7	21	3	0	1	0	1	0	0	1	2	1	1	6	0	4	2	6	0	2	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:54856684G>T	uc002rxu.2	+	14	2662	c.2413G>T	c.(2413-2415)GAA>TAA	p.E805*	SPTBN1_uc002rxv.1_Nonsense_Mutation_p.E805*|SPTBN1_uc002rxx.2_Nonsense_Mutation_p.E792*	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	805	Spectrin 5.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CACGCTGCACGAACAAGCCAG	0.607													18	55					1.67942e-08	2.41256e-08	1	0	T	54856684	T	T	54856684	4	4	221	1	0	0	0	0	0	1	0	0	15185	1059	37	3	2576	3	SPTBN1	2	54856684	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	7720452	54856684	188342689	47	40573											
C2orf63	130162	broad.mit.edu	37	chr2	55403114	55403114	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcatttatcataagactttCtactgcatctgtggggaaaa	13	14	7	7	0	4	1	2	0	2	1	4	2	4	2	0	2	2	1	0	2	5	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:55403114C>G	uc002ryi.2	-	13	1919	c.1573G>C	c.(1573-1575)GAA>CAA	p.E525Q	C2orf63_uc002ryh.2_Missense_Mutation_p.E76Q|C2orf63_uc002ryj.2_Missense_Mutation_p.E403Q	NM_152385	NP_689598	Q8NHS4	CB063_HUMAN	hypothetical protein LOC130162 isoform 1	525							binding			ovary(2)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(58;0.179)|Lung(47;0.189)			ATAAGACTTTCTACTGCATCT	0.299													9	27					0	0	0	0	G	55403114	G	G	55403114	3	3	221	1	0	0	0	0	1	0	0	0	2192	922	32	2	191	2	C2orf63	2	55403114	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	546430	55403114	187796259	48	40574											
PROKR1	10887	broad.mit.edu	37	chr2	68882429	68882429	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctatgctgggcgcccttctaCggcttcaccatcgtgcgcga	5	10	11	15	5	2	0	1	0	1	0	3	1	2	0	2	2	3	2	2	2	2	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:68882429C>T	uc010yqj.1	+	2	903	c.903C>T	c.(901-903)TAC>TAT	p.Y301Y	PROKR1_uc002ses.2_RNA	NM_138964	NP_620414	Q8TCW9	PKR1_HUMAN	G protein-coupled receptor 73	301	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(1)	1						CGCCCTTCTACGGCTTCACCA	0.587													18	45					0	0	0	0	T	68882429	T	T	68882429	2	4	221	1	0	0	0	0	0	0	0	1	12614	547	19	1		1	PROKR1	2	68882429	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	13479315	68882429	174316944	49	40575											
ZNF638	27332	broad.mit.edu	37	chr2	71576307	71576307	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatgaatgttcaggtaactCaacacagaactgatccaaga	17	8	8	8	0	2	4	2	2	0	2	3	5	3	4	1	1	3	2	1	1	6	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:71576307C>G	uc002shx.2	+	2	542	c.223C>G	c.(223-225)CAA>GAA	p.Q75E	ZNF638_uc010fec.2_Missense_Mutation_p.Q181E|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Missense_Mutation_p.Q75E|ZNF638_uc002shy.2_Missense_Mutation_p.Q75E|ZNF638_uc002shz.2_Missense_Mutation_p.Q75E|ZNF638_uc002sia.2_Missense_Mutation_p.Q75E|ZNF638_uc002sib.1_Missense_Mutation_p.Q75E	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	75					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TCAGGTAACTCAACACAGAAC	0.463													3	95					0	0	0	0	G	71576307	G	G	71576307	3	3	221	1	0	0	0	0	1	0	0	0	18122	827	29	2	225	2	ZNF638	2	71576307	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2693878	71576307	171623066	50	40576											
ALMS1	7840	broad.mit.edu	37	chr2	73676052	73676052	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctggaccagctgaccagAagactggcctaccaacagta	12	7	10	12	0	0	3	0	1	0	2	0	4	0	4	4	2	4	3	4	2	4	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:73676052A>G	uc002sje.1	+	10	2512	c.2401A>G	c.(2401-2403)AAG>GAG	p.K801E	ALMS1_uc002sjf.1_Missense_Mutation_p.K757E|ALMS1_uc002sjg.2_Missense_Mutation_p.K187E|ALMS1_uc002sjh.1_Missense_Mutation_p.K187E	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	799	6.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						AGCTGACCAGAAGACTGGCCT	0.488													54	119					0	0	0	0	G	73676052	G	G	73676052	3	3	221	1	0	0	0	0	1	0	0	0	535	247	9	5	2425	5	ALMS1	2	73676052	Missense_Mutation	SNP	A	TCGA-CV-7099-01A-41D-2012-08	2099745	73676052	169523321	51	40577											
TEKT4	150483	broad.mit.edu	37	chr2	95539303	95539303	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacattcaggagctgctgaaGagaaccatcatgcaagcagt	15	7	10	9	0	2	2	2	1	0	1	2	4	2	3	1	1	6	4	1	1	4	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:95539303G>C	uc002stw.1	+	2	630	c.537G>C	c.(535-537)AAG>AAC	p.K179N	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	179	Potential.				cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3						AGCTGCTGAAGAGAACCATCA	0.612													9	36					0	0	0	0	C	95539303	C	C	95539303	3	2	221	1	0	0	0	0	1	0	0	0	15821	933	33	2	543	2	TEKT4	2	95539303	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	21863251	95539303	147660070	52	40578											
CNNM3	26505	broad.mit.edu	37	chr2	97483071	97483071	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acacgcgcatcccggtgtacGaggaggagcgctccaacatc	10	5	12	14	5	0	0	0	0	0	0	3	3	2	2	2	3	3	3	2	3	2	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:97483071G>C	uc002swy.2	+	1	1081	c.1057G>C	c.(1057-1059)GAG>CAG	p.E353Q	CNNM3_uc002swz.2_Missense_Mutation_p.E353Q	NM_017623	NP_060093	Q8NE01	CNNM3_HUMAN	cyclin M3 isoform 1	353	CBS 1.				ion transport	integral to membrane|plasma membrane	protein binding			ovary(1)	1						CCCGGTGTACGAGGAGGAGCG	0.617													21	43					0	0	0	0	C	97483071	C	C	97483071	3	2	221	1	0	0	0	0	1	0	0	0	3629	1059	37	3	1059	3	CNNM3	2	97483071	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1943768	97483071	145716302	53	40579											
ST6GAL2	84620	broad.mit.edu	37	chr2	107460077	107460077	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggtagaaagcactttgagaTtttctccccacctgggatga	10	11	11	9	0	1	3	0	2	1	2	2	5	1	4	3	2	1	2	3	2	2	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:107460077T>G	uc002tdq.2	-	2	476	c.357A>C	c.(355-357)AAA>AAC	p.K119N	ST6GAL2_uc002tdr.2_Missense_Mutation_p.K119N|ST6GAL2_uc002tds.3_Missense_Mutation_p.K119N	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	119	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CACTTTGAGATTTTCTCCCCA	0.532													13	130					0	0	0	0	G	107460077	G	G	107460077	3	3	221	1	0	0	0	0	1	0	0	0	15288	1490	52	5	1339	5	ST6GAL2	2	107460077	Missense_Mutation	SNP	T	TCGA-CV-7099-01A-41D-2012-08	9977006	107460077	135739296	54	40580											
IL1F8	27177	broad.mit.edu	37	chr2	113780314	113780314	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatctttgtccttcttcctGagatggtgatgttgaaagga	10	15	10	6	0	2	3	0	3	2	1	4	5	4	4	2	2	0	1	2	2	2	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:113780314G>A	uc002tiq.1	-	6	536	c.432C>T	c.(430-432)CTC>CTT	p.L144L		NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	144					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						CCTTCTTCCTGAGATGGTGAT	0.433													30	53					0	0	0	0	A	113780314	A	A	113780314	2	1	221	1	0	0	0	0	0	0	0	1	7695	1277	45	2		2	IL1F8	2	113780314	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	6320237	113780314	129419059	55	40581											
PSD4	23550	broad.mit.edu	37	chr2	113940969	113940969	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgggggacggcgctgctatCagtgggcattgtacccctcc	5	10	14	12	2	1	0	1	0	0	0	2	1	2	1	3	4	2	4	3	4	2	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:113940969C>T	uc002tjc.2	+	2	1119	c.936C>T	c.(934-936)ATC>ATT	p.I312I	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Silent_p.I311I|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	312					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						GCGCTGCTATCAGTGGGCATT	0.617													9	30					0	0	0	0	T	113940969	T	T	113940969	2	4	221	1	0	0	0	0	0	0	0	1	12711	816	29	2		2	PSD4	2	113940969	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	160655	113940969	129258404	56	40582											
TMEM37	140738	broad.mit.edu	37	chr2	120194890	120194890	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgggttttgtgatcctcctCaggaaccaagtcacactcat	9	12	8	12	0	3	1	3	1	0	0	5	2	5	2	3	2	1	1	3	2	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:120194890C>G	uc002tly.2	+	2	481	c.447C>G	c.(445-447)CTC>CTG	p.L149L		NM_183240	NP_899063	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	149	Helical; (Potential).					integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)	1						TGATCCTCCTCAGGAACCAAG	0.547													80	214					0	0	0	0	G	120194890	G	G	120194890	2	3	221	1	0	0	0	0	0	0	0	1	16224	813	29	2		2	TMEM37	2	120194890	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	6253921	120194890	123004483	57	40583											
NEB	4703	broad.mit.edu	37	chr2	152512709	152512709	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctggtcagctcaatgttCattgcatctggaaggaggat	9	13	11	8	0	4	0	3	0	1	0	5	3	5	3	1	4	2	3	1	4	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:152512709C>T	uc010fnx.2	-	49	6644	c.6453G>A	c.(6451-6453)ATG>ATA	p.M2151I		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2151	Nebulin 57.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCTCAATGTTCATTGCATCTG	0.468													98	280					0	0	0	0	T	152512709	T	T	152512709	3	4	221	1	0	0	0	0	1	0	0	0	10356	826	29	2	19769	2	NEB	2	152512709	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	32317819	152512709	90686664	58	40584											
TANK	10010	broad.mit.edu	37	chr2	162060088	162060088	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctaaaatctcagttacttCttgtgaattccactcaaggt	12	14	6	9	0	3	1	2	1	2	0	5	1	4	1	1	1	2	2	1	1	5	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:162060088C>T	uc002ubr.1	+	3	348	c.190C>T	c.(190-192)CTT>TTT	p.L64F	TANK_uc002ubq.1_Missense_Mutation_p.L64F|TANK_uc002ubs.2_Missense_Mutation_p.L64F	NM_004180	NP_004171	Q92844	TANK_HUMAN	TRAF interacting protein TANK isoform a	64						cytosol	metal ion binding|protein binding			ovary(1)	1						TCAGTTACTTCTTGTGAATTC	0.343													15	29					0	0	0	0	T	162060088	T	T	162060088	3	4	221	1	0	0	0	0	1	0	0	0	15612	913	32	2	196	2	TANK	2	162060088	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	9547379	162060088	81139285	59	40585											
TBR1	10716	broad.mit.edu	37	chr2	162273175	162273175	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagagaagtaaactctctcCtgtcttggacggggtctctg	8	11	11	11	1	3	1	0	0	3	1	6	3	4	2	2	3	1	1	2	3	3	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:162273175C>T	uc002ubw.1	+	1	556	c.254C>T	c.(253-255)CCT>CTT	p.P85L	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	85						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						AAACTCTCTCCTGTCTTGGAC	0.522													11	142					0	0	0	0	T	162273175	T	T	162273175	3	4	221	1	0	0	0	0	1	0	0	0	15713	681	24	4	256	4	TBR1	2	162273175	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	213087	162273175	80926198	60	40586											
KCNH7	90134	broad.mit.edu	37	chr2	163693250	163693250	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatggcacagttctgcactCtggcatttgcaatgataaat	11	13	9	8	0	2	2	0	2	2	0	2	2	2	2	0	2	2	5	0	2	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:163693250C>T	uc002uch.1	-	2	316	c.104G>A	c.(103-105)AGA>AAA	p.R35K	KCNH7_uc002uci.2_Missense_Mutation_p.R35K	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	35	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	GTTCTGCACTCTGGCATTTGC	0.403													10	16					0	0	0	0	T	163693250	T	T	163693250	3	4	221	1	0	0	0	0	1	0	0	0	8076	913	32	2	3612	2	KCNH7	2	163693250	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1420075	163693250	79506123	61	40587											
KBTBD10	10324	broad.mit.edu	37	chr2	170366343	170366343	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctttaccaatccacccttCttcaggatggtctaaaagat	11	12	7	11	0	3	1	1	0	2	1	4	2	4	2	3	3	1	1	3	3	4	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:170366343C>T	uc002ueu.1	+	1	132	c.55C>T	c.(55-57)CTT>TTT	p.L19F	KBTBD10_uc010zdh.1_Intron	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	19					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						ATCCACCCTTCTTCAGGATGG	0.468													34	55					0	0	0	0	T	170366343	T	T	170366343	3	4	221	1	0	0	0	0	1	0	0	0	8029	913	32	2	57	2	KBTBD10	2	170366343	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	6673093	170366343	72833030	62	40588											
NFE2L2	4780	broad.mit.edu	37	chr2	178098810	178098810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggagaaattcacctgtctCttcatctagttgtaactgag	10	14	9	8	0	4	2	2	1	2	1	5	3	4	2	1	1	1	2	1	1	3	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:178098810C>T	uc002ulh.3	-	2	790	c.235G>A	c.(235-237)GAG>AAG	p.E79K	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63K|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63K|NFE2L2_uc002uli.3_Missense_Mutation_p.E63K|NFE2L2_uc010fra.2_Missense_Mutation_p.E63K|NFE2L2_uc010frb.2_Missense_Mutation_p.E63K	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			6	59					0	0	0	0	T	178098810	T	T	178098810	3	4	221	1	0	0	0	0	1	0	0	0	10422	922	32	2	1598	2	NFE2L2	2	178098810	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	7732467	178098810	65100563	63	40589											
SATB2	23314	broad.mit.edu	37	chr2	200137185	200137185	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtttggggagatccagctGagccgaaagagtgtggatgg	9	9	18	5	1	0	3	0	1	0	2	1	6	1	4	2	4	2	2	2	4	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:200137185G>A	uc002uuy.1	-	11	2768	c.1951C>T	c.(1951-1953)CAG>TAG	p.Q651*	SATB2_uc010fsq.1_Nonsense_Mutation_p.Q533*|SATB2_uc002uuz.1_Nonsense_Mutation_p.Q651*|SATB2_uc002uva.1_Nonsense_Mutation_p.Q651*	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	651	Homeobox.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGATCCAGCTGAGCCGAAAGA	0.542													26	57					0	0	0	0	A	200137185	A	A	200137185	4	1	221	1	0	0	0	0	0	1	0	0	13919	1299	45	2	254	2	SATB2	2	200137185	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	22038375	200137185	43062188	64	40590											
CASP8	841	broad.mit.edu	37	chr2	202151270	202151270	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatggggaaacagatgcctCagcctactttcacactaaga	14	8	8	11	0	2	2	2	0	0	2	2	3	2	3	2	2	4	0	2	2	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:202151270C>T	uc002uxr.1	+	10	1602	c.1393C>T	c.(1393-1395)CAG>TAG	p.Q465*	CASP8_uc002uxp.1_Nonsense_Mutation_p.Q482*|CASP8_uc002uxq.1_Nonsense_Mutation_p.Q450*|CASP8_uc002uxt.1_Nonsense_Mutation_p.Q524*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.Q450*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.Q381*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	465					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						ACAGATGCCTCAGCCTACTTT	0.313										HNSCC(4;0.00038)			10	19					0	0	0	0	T	202151270	T	T	202151270	4	4	221	1	0	0	0	0	0	1	0	0	2689	827	29	2	1704	2	CASP8	2	202151270	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2014085	202151270	41048103	65	40591											
INO80D	54891	broad.mit.edu	37	chr2	206869474	206869474	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgagaaggttgctaaatggaGaggggtctccaaggttgaca	12	8	15	6	1	1	3	0	1	1	2	2	5	1	3	1	5	1	3	1	5	4	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:206869474G>C	uc002vaz.3	-	11	3107	c.2702C>G	c.(2701-2703)TCT>TGT	p.S901C		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GCTAAATGGAGAGGGGTCTCC	0.567													20	39					0	0	0	0	C	206869474	C	C	206869474	3	2	221	1	0	0	0	0	1	0	0	0	7788	942	33	2	385	2	INO80D	2	206869474	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4718204	206869474	36329899	66	40592											
SEPT2	4735	broad.mit.edu	37	chr2	242282467	242282467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttacctgatgcagaatcaGatgaagatgaagattttaaa	17	11	8	5	0	1	7	1	3	0	4	1	7	1	7	1	0	2	1	1	0	6	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr2:242282467G>A	uc002wbc.2	+	9	1076	c.655G>A	c.(655-657)GAT>AAT	p.D219N	SEPT2_uc002wbd.2_Missense_Mutation_p.D219N|SEPT2_uc002wbf.2_Missense_Mutation_p.D219N|SEPT2_uc002wbg.2_Missense_Mutation_p.D219N|SEPT2_uc002wbh.2_Missense_Mutation_p.D229N|SEPT2_uc010zop.1_Missense_Mutation_p.D254N	NM_001008491	NP_001008491	Q15019	SEPT2_HUMAN	septin 2	219					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(1)	1		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		TGCAGAATCAGATGAAGATGA	0.358													45	107					0	0	0	0	A	242282467	A	A	242282467	3	1	221	1	0	0	0	0	1	0	0	0	14129	942	33	2	681	2	SEPT2	2	242282467	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	35412993	242282467	916906	67	40593											
CNTN4	152330	broad.mit.edu	37	chr3	2777987	2777987	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggagaaaaaagtgaagctCaattgtgaagttaaaggaaa	20	7	12	2	0	1	3	1	2	0	1	1	6	1	4	0	2	1	2	0	2	9	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:2777987C>G	uc003bpc.2	+	4	365	c.144C>G	c.(142-144)CTC>CTG	p.L48L	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Silent_p.L48L	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	48	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AAGTGAAGCTCAATTGTGAAG	0.348													9	84					0	0	0	0	G	2777987	G	G	2777987	2	3	221	1	0	0	0	0	0	0	0	1	3658	813	29	2		2	CNTN4	3	2777987	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08		2777987	195244443	68	40594											
RPUSD3	285367	broad.mit.edu	37	chr3	9879867	9879867	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagggggtcaggtggaggcGtctgaggagggcttcatcca	7	7	20	7	1	3	1	2	1	1	0	4	4	4	4	1	8	0	1	1	8	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:9879867G>A	uc011atk.1	-	9	893	c.889C>T	c.(889-891)CGC>TGC	p.R297C	ARPC4_uc003btc.1_Intron|RPUSD3_uc011atl.1_Missense_Mutation_p.R282C	NM_173659	NP_775930	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	297					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(1)	1	Medulloblastoma(99;0.227)					AGGTGGAGGCGTCTGAGGAGG	0.622													7	40					0	0	0	0	A	9879867	A	A	9879867	3	1	221	1	0	0	0	0	1	0	0	0	13733	1145	40	1	170	1	RPUSD3	3	9879867	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	7101880	9879867	188142563	69	40595											
MST1R	4486	broad.mit.edu	37	chr3	49932708	49932708	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcccttagctggatggactCtttccgcagcagtggcacac	7	10	11	13	1	1	0	0	0	1	0	3	2	3	2	2	3	2	4	2	3	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:49932708C>T	uc003cxy.3	-	14	3427	c.3163G>A	c.(3163-3165)GAG>AAG	p.E1055K	MST1R_uc011bdc.1_5'UTR	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1055	Cytoplasmic (Potential).				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGGATGGACTCTTTCCGCAGC	0.552													59	84					0	0	0	0	T	49932708	T	T	49932708	3	4	221	1	0	0	0	0	1	0	0	0	9944	922	32	2	1067	2	MST1R	3	49932708	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	40052841	49932708	148089722	70	40596											
CD96	10225	broad.mit.edu	37	chr3	111304196	111304196	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagaaatccctgtgattgtgGaaaataactccacggatgtc	13	10	9	9	1	0	2	0	1	0	1	3	4	2	4	2	2	1	0	2	2	4	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:111304196G>A	uc003dxw.2	+	6	996	c.826G>A	c.(826-828)GAA>AAA	p.E276K	CD96_uc003dxv.2_Missense_Mutation_p.E260K|CD96_uc003dxx.2_Missense_Mutation_p.E260K|CD96_uc010hpy.1_Missense_Mutation_p.E260K	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	276	Extracellular (Potential).|Ig-like C2-type.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						TGTGATTGTGGAAAATAACTC	0.413									Opitz_Trigonocephaly_syndrome				6	30					0	0	0	0	A	111304196	A	A	111304196	3	1	221	1	0	0	0	0	1	0	0	0	3063	1175	41	2	848	2	CD96	3	111304196	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	61371488	111304196	86718234	71	40597											
POLQ	10721	broad.mit.edu	37	chr3	121158907	121158907	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgccttcccaaaatggtctGaacaaatccgtctcttttac	11	12	5	13	2	2	1	0	1	2	0	5	1	4	1	3	1	2	0	3	1	5	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:121158907G>C	uc003eee.3	-	27	7450	c.7321C>G	c.(7321-7323)CAG>GAG	p.Q2441E	POLQ_uc003eed.2_Missense_Mutation_p.Q1613E	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2441					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AAAATGGTCTGAACAAATCCG	0.323								DNA_polymerases_(catalytic_subunits)					16	43					0	0	0	0	C	121158907	C	C	121158907	3	2	221	1	0	0	0	0	1	0	0	0	12263	1299	45	2	467	2	POLQ	3	121158907	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	9854711	121158907	76863523	72	40598											
ALDH1L1	10840	broad.mit.edu	37	chr3	125872405	125872405	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcctgaagtgttcagcgttGagttgaaaaatgtcagtttc	10	13	12	6	1	2	3	2	3	0	0	3	3	2	3	1	1	1	4	1	1	3	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:125872405G>C	uc003eim.1	-	7	930	c.740C>G	c.(739-741)TCA>TGA	p.S247*	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Nonsense_Mutation_p.S146*|ALDH1L1_uc003eio.2_5'UTR|ALDH1L1_uc010hsf.1_Nonsense_Mutation_p.S273*|ALDH1L1_uc003eip.1_Nonsense_Mutation_p.S154*|ALDH1L1_uc011bkj.1_Nonsense_Mutation_p.S72*	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	247					10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GTTCAGCGTTGAGTTGAAAAA	0.567													18	33					0	0	0	0	C	125872405	C	C	125872405	4	2	221	1	0	0	0	0	0	1	0	0	494	1294	45	2	2036	2	ALDH1L1	3	125872405	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4713498	125872405	72150025	73	40599											
TPRA1	131601	broad.mit.edu	37	chr3	127294643	127294643	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgggaaggatgaccaccaGagagtagacctacagagaca	15	5	12	9	0	0	4	0	1	0	3	0	8	0	6	3	2	1	1	3	2	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:127294643G>A	uc003ejl.2	-	7	910	c.619C>T	c.(619-621)CTG>TTG	p.L207L	TPRA1_uc003ejm.2_Intron|TPRA1_uc003ejo.2_Silent_p.L207L|TPRA1_uc010hsk.2_Intron|TPRA1_uc003ejn.2_Silent_p.L207L	NM_016372	NP_057456	Q86W33	TPRA1_HUMAN	G protein-coupled receptor 175 isoform 1	207	Helical; Name=5; (Potential).				aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity				0						ATGACCACCAGAGAGTAGACC	0.642													15	52					0	0	0	0	A	127294643	A	A	127294643	2	1	221	1	0	0	0	0	0	0	0	1	16484	933	33	2		2	TPRA1	3	127294643	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1422238	127294643	70727787	74	40600											
RPN1	6184	broad.mit.edu	37	chr3	128348837	128348837	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cttgggaggttgtagccaacGatgtaatgggtcttccaccc	8	11	12	10	1	1	0	0	0	1	0	2	2	2	1	3	3	2	3	3	3	3	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:128348837G>C	uc003ekr.1	-	5	1069	c.993C>G	c.(991-993)ATC>ATG	p.I331M	RPN1_uc011bkq.1_Missense_Mutation_p.I159M	NM_002950	NP_002941	P04843	RPN1_HUMAN	ribophorin I precursor	331	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|melanosome|oligosaccharyltransferase complex|rough microsome	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(114;0.189)		TGTAGCCAACGATGTAATGGG	0.433			T	EVI1	AML								11	30					0	0	0	0	C	128348837	C	C	128348837	3	2	221	1	0	0	0	0	1	0	0	0	13672	1048	37	3	854	3	RPN1	3	128348837	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1054194	128348837	69673593	75	40601											
NCK1	4690	broad.mit.edu	37	chr3	136667114	136667114	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttttagccaaatgatttctCagtatcactaaaagcacaag	15	12	5	9	0	2	1	2	1	1	0	3	1	2	1	1	0	2	2	1	0	6	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:136667114C>G	uc003erh.2	+	4	1060	c.953C>G	c.(952-954)TCA>TGA	p.S318*	NCK1_uc011bme.1_Nonsense_Mutation_p.S254*	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	318	SH2.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1						AATGATTTCTCAGTATCACTA	0.299													3	40					0	0	0	0	G	136667114	G	G	136667114	4	3	221	1	0	0	0	0	0	1	0	0	10273	838	29	2	963	2	NCK1	3	136667114	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	8318277	136667114	61355316	76	40602											
SLC25A36	55186	broad.mit.edu	37	chr3	140692589	140692589	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggcgaatgggtgcttttGaatgtgttcgtaaagtgtat	11	14	13	3	2	0	1	0	1	0	0	1	2	0	1	0	2	1	4	0	2	6	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:140692589G>A	uc003etr.2	+	6	719	c.484G>A	c.(484-486)GAA>AAA	p.E162K	SLC25A36_uc003ets.2_Missense_Mutation_p.E162K|SLC25A36_uc003etq.2_Missense_Mutation_p.E5K|SLC25A36_uc011bmz.1_Missense_Mutation_p.E136K	NM_001104647	NP_001098117	Q96CQ1	S2536_HUMAN	solute carrier family 25, member 36 isoform a	162	Solcar 2.				response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						GGGTGCTTTTGAATGTGTTCG	0.353													11	23					0	0	0	0	A	140692589	A	A	140692589	3	1	221	1	0	0	0	0	1	0	0	0	14564	1291	45	2	506	2	SLC25A36	3	140692589	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4025475	140692589	57329841	77	40603											
RNF13	11342	broad.mit.edu	37	chr3	149589832	149589832	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagggttttttgattaactCaaaaccagagaatgcctgtg	12	13	9	7	0	2	2	2	1	0	1	2	3	2	2	2	1	3	1	2	1	4	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:149589832C>G	uc003exn.3	+	5	996	c.212C>G	c.(211-213)TCA>TGA	p.S71*	RNF13_uc003exp.3_Nonsense_Mutation_p.S71*|RNF13_uc010hvh.2_5'UTR	NM_007282	NP_009213	O43567	RNF13_HUMAN	ring finger protein 13	71	PA.|Lumenal (Potential).				protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			TTGATTAACTCAAAACCAGAG	0.328													6	33					0	0	0	0	G	149589832	G	G	149589832	4	3	221	1	0	0	0	0	0	1	0	0	13502	838	29	2	222	2	RNF13	3	149589832	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	8897243	149589832	48432598	78	40604											
MED12L	116931	broad.mit.edu	37	chr3	150840608	150840608	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcatattagctgagaaactGaagcttaacactttccagga	15	10	8	8	0	0	2	0	2	0	1	1	4	1	3	1	1	5	3	1	1	5	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:150840608G>A	uc003eyp.2	+	3	281	c.243G>A	c.(241-243)CTG>CTA	p.L81L	MED12L_uc011bnz.1_Silent_p.L81L|MED12L_uc003eym.1_Silent_p.L81L|MED12L_uc003eyn.2_Silent_p.L81L|MED12L_uc003eyo.2_Silent_p.L81L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	81					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTGAGAAACTGAAGCTTAACA	0.378													5	14					0	0	0	0	A	150840608	A	A	150840608	2	1	221	1	0	0	0	0	0	0	0	1	9482	1277	45	2		2	MED12L	3	150840608	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1250776	150840608	47181822	79	40605											
MECOM	2122	broad.mit.edu	37	chr3	168833803	168833803	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagggcttactttgtctttGaacattttaccattttcttt	8	20	6	7	0	2	2	0	1	2	1	2	2	2	2	1	1	3	1	1	1	3	8			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:168833803G>A	uc003ffi.3	-	7	1562	c.1293C>T	c.(1291-1293)TTC>TTT	p.F431F	MECOM_uc010hwk.1_Silent_p.F454F|MECOM_uc003ffj.3_Silent_p.F496F|MECOM_uc011bpi.1_Silent_p.F432F|MECOM_uc003ffn.3_Silent_p.F431F|MECOM_uc003ffk.2_Silent_p.F431F|MECOM_uc003ffl.2_Silent_p.F591F|MECOM_uc011bpj.1_Silent_p.F619F|MECOM_uc011bpk.1_Silent_p.F421F|MECOM_uc010hwn.2_Silent_p.F619F	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	431	Nuclear localization signal (Potential).				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CTTTGTCTTTGAACATTTTAC	0.378													20	45					0	0	0	0	A	168833803	A	A	168833803	2	1	221	1	0	0	0	0	0	0	0	1	9475	1281	45	2		2	MECOM	3	168833803	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	17993195	168833803	29188627	80	40606											
TNIK	23043	broad.mit.edu	37	chr3	170819256	170819256	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcagtctgggtatgtcgCtgacagccactgtcccatca	9	10	9	13	1	3	1	2	1	1	0	5	1	4	1	2	1	1	2	2	1	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:170819256C>G	uc003fhh.2	-	22	2918	c.2573G>C	c.(2572-2574)AGC>ACC	p.S858T	TNIK_uc003fhi.2_Missense_Mutation_p.S803T|TNIK_uc003fhj.2_Missense_Mutation_p.S829T|TNIK_uc003fhk.2_Missense_Mutation_p.S850T|TNIK_uc003fhl.2_Missense_Mutation_p.S774T|TNIK_uc003fhm.2_Missense_Mutation_p.S795T|TNIK_uc003fhn.2_Missense_Mutation_p.S821T|TNIK_uc003fho.2_Missense_Mutation_p.S766T|TNIK_uc003fhg.2_Missense_Mutation_p.S36T	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	858	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGGTATGTCGCTGACAGCCAC	0.453													109	245					0	0	0	0	G	170819256	G	G	170819256	3	3	221	1	0	0	0	0	1	0	0	0	16379	797	28	4	1557	4	TNIK	3	170819256	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1985453	170819256	27203174	81	40607											
FXR1	8087	broad.mit.edu	37	chr3	180685989	180685989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaagaggcagaagtgtttCagggggtcgaggtcgtggtg	9	8	20	4	2	1	2	1	0	0	2	3	4	1	3	0	6	0	2	0	6	2	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:180685989C>T	uc003fkq.2	+	14	1371	c.1349C>T	c.(1348-1350)TCA>TTA	p.S450L	FXR1_uc003fkp.2_Missense_Mutation_p.S365L|FXR1_uc003fkr.2_Missense_Mutation_p.S450L|FXR1_uc011bqj.1_Missense_Mutation_p.S364L|FXR1_uc003fks.2_Missense_Mutation_p.S393L|FXR1_uc011bqk.1_Missense_Mutation_p.S401L|FXR1_uc011bql.1_Missense_Mutation_p.S437L	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	450	RNA-binding RGG-box.				apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			AGAAGTGTTTCAGGGGGTCGA	0.512													18	38					0	0	0	0	T	180685989	T	T	180685989	3	4	221	1	0	0	0	0	1	0	0	0	6149	838	29	2	1403	2	FXR1	3	180685989	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	9866733	180685989	17336441	82	40608											
CLCN2	1181	broad.mit.edu	37	chr3	184079208	184079221	+	Frame_Shift_Del	DEL	GGTCTGCTCGTACT	-	-																															agctcagcttcacttaccagGgtctgctcgtactgcagcgc																								rs143436017		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr3:184079208_184079221delGGTCTGCTCGTACT	uc003foi.2	-	1	171_184	c.47_60delAGTACGAGCAGACC	c.(46-60)CAGTACGAGCAGACCfs	p.Q16fs	CLCN2_uc010hya.1_Frame_Shift_Del_p.Q16fs|CLCN2_uc011brl.1_Frame_Shift_Del_p.Q16fs|CLCN2_uc011brm.1_Frame_Shift_Del_p.Q16fs|CLCN2_uc011brn.1_Frame_Shift_Del_p.Q16fs|POLR2H_uc003foj.1_5'Flank|POLR2H_uc003fok.1_5'Flank	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	16_20	Cytoplasmic (By similarity).					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	CACTTACCAGGGTCTGCTCGTACTGCAGCGCCCG	0.692													---	---	---								-	184079221	-	-	184079208	7	5	221	1	0	1	0	1	0	0	0	0	3478	1219	43	0	2732	0	CLCN2	3	184079208	Frame_Shift_Del	DEL	GGTCTGCTCGTACT	TCGA-CV-7099-01A-41D-2012-08	3393219	184079208	13943222	83	40609											
EVC2	132884	broad.mit.edu	37	chr4	5586467	5586467	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggtgtaggccgacagagtCtcggtcacccgggacgcctt	6	7	15	13	5	2	1	1	0	1	1	3	3	2	2	3	4	0	1	3	4	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:5586467C>G	uc003gij.2	-	17	2994	c.2940G>C	c.(2938-2940)GAG>GAC	p.E980D	EVC2_uc011bwb.1_Missense_Mutation_p.E420D|EVC2_uc003gik.2_Missense_Mutation_p.E900D	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	980						integral to membrane				large_intestine(3)|ovary(2)	5						CCGACAGAGTCTCGGTCACCC	0.602													22	34					0	0	0	0	G	5586467	G	G	5586467	3	3	221	1	0	0	0	0	1	0	0	0	5310	912	32	2	1010	2	EVC2	4	5586467	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08		5586467	185567809	84	40610											
N4BP2	55728	broad.mit.edu	37	chr4	40122465	40122465	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taagtgagcccaacctagaaAttggaacaaatgacaaaatg	19	7	8	7	0	0	3	0	2	0	1	0	4	0	4	2	1	3	0	2	1	8	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:40122465A>G	uc003guy.3	+	9	3072	c.2734A>G	c.(2734-2736)ATT>GTT	p.I912V	N4BP2_uc010ifq.2_Missense_Mutation_p.I832V|N4BP2_uc010ifr.2_Missense_Mutation_p.I832V	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	912						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						CAACCTAGAAATTGGAACAAA	0.413													16	43					0	0	0	0	G	40122465	G	G	40122465	3	3	221	1	0	0	0	0	1	0	0	0	10163	101	4	5	2760	5	N4BP2	4	40122465	Missense_Mutation	SNP	A	TCGA-CV-7099-01A-41D-2012-08	34535998	40122465	151031811	85	40611											
DCAF4L1	285429	broad.mit.edu	37	chr4	41984001	41984001	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggtccaaattcggagcttGgatccctcctctttggcgag	8	11	11	11	2	1	0	0	0	1	0	5	3	4	2	3	4	1	1	3	4	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:41984001G>C	uc003gwk.2	+	1	289	c.192G>C	c.(190-192)TTG>TTC	p.L64F		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	64										skin(1)	1						TTCGGAGCTTGGATCCCTCCT	0.532													3	62					0	0	0	0	C	41984001	C	C	41984001	3	2	221	1	0	0	0	0	1	0	0	0	4288	1339	47	4	194	4	DCAF4L1	4	41984001	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1861536	41984001	149170275	86	40612											
ATP8A1	10396	broad.mit.edu	37	chr4	42571206	42571206	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggagagcagccataatcctCaggttcagggacatggcttc	11	8	12	10	0	2	1	2	0	0	1	4	3	3	2	2	4	2	3	2	4	1	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:42571206C>G	uc003gwr.2	-	15	1544	c.1312G>C	c.(1312-1314)GAG>CAG	p.E438Q	ATP8A1_uc003gws.2_Intron|ATP8A1_uc011byz.1_Intron	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	438	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	CCATAATCCTCAGGTTCAGGG	0.408													14	41					0	0	0	0	G	42571206	G	G	42571206	3	3	221	1	0	0	0	0	1	0	0	0	1194	835	29	2	2274	2	ATP8A1	4	42571206	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	587205	42571206	148583070	87	40613											
DCK	1633	broad.mit.edu	37	chr4	71859630	71859630	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgcatcaagaaaatctccatCgaagggaacatcggtaagga	16	6	10	9	3	2	1	1	0	1	1	5	4	2	3	1	3	1	2	1	3	6	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:71859630C>G	uc003hfx.2	+	1	366	c.78C>G	c.(76-78)ATC>ATG	p.I26M	DCK_uc011cbb.1_Translation_Start_Site	NM_000788	NP_000779	P27707	DCK_HUMAN	deoxycytidine kinase	26					purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			ovary(1)	1			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)	AAATCTCCATCGAAGGGAACA	0.602													7	15					0	0	0	0	G	71859630	G	G	71859630	3	3	221	1	0	0	0	0	1	0	0	0	4307	874	31	3	80	3	DCK	4	71859630	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	29288424	71859630	119294646	88	40614											
SLC4A4	8671	broad.mit.edu	37	chr4	72423435	72423435	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctttcctccccagttcatgGatcgtctgaagctgcttctg	5	15	8	13	1	4	1	1	1	3	0	7	2	6	2	3	1	2	3	3	1	1	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:72423435G>T	uc003hfy.2	+	22	2887	c.2770G>T	c.(2770-2772)GAT>TAT	p.D924Y	SLC4A4_uc010iic.2_Missense_Mutation_p.D924Y|SLC4A4_uc010iib.2_Missense_Mutation_p.D840Y|SLC4A4_uc003hfz.2_Missense_Mutation_p.D924Y|SLC4A4_uc003hgc.3_Missense_Mutation_p.D880Y|SLC4A4_uc010iid.2_Missense_Mutation_p.D128Y	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	924	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CCAGTTCATGGATCGTCTGAA	0.443													5	49					3.59834e-05	5.07895e-05	1	0	T	72423435	T	T	72423435	3	4	221	1	0	0	0	0	1	0	0	0	14720	1174	41	2	2973	2	SLC4A4	4	72423435	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	563805	72423435	118730841	89	40615											
FRAS1	80144	broad.mit.edu	37	chr4	79387417	79387417	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgccatggcaccatcgagcGaaccagcaatgggcagcatt	12	5	11	13	3	0	0	0	0	0	0	1	2	0	0	3	2	4	4	3	2	2	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:79387417G>A	uc003hlb.2	+	50	7525	c.7085G>A	c.(7084-7086)CGA>CAA	p.R2362Q		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2361	CSPG 11.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ACCATCGAGCGAACCAGCAAT	0.557													19	63					0	0	0	0	A	79387417	A	A	79387417	3	1	221	1	0	0	0	0	1	0	0	0	6076	1058	37	1	7358	1	FRAS1	4	79387417	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	6963982	79387417	111766859	90	40616											
BMP2K	55589	broad.mit.edu	37	chr4	79780824	79780824	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aatttgccaaaaaggattgtCcagtctccaacatcaatgta	15	11	6	9	0	2	0	1	0	1	0	4	1	3	1	3	1	2	1	3	1	6	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:79780824C>G	uc003hlk.2	+	8	1136	c.970C>G	c.(970-972)CCA>GCA	p.P324A	BMP2K_uc010ijl.1_RNA|BMP2K_uc003hlj.2_Missense_Mutation_p.P324A	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	324						nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						AAAGGATTGTCCAGTCTCCAA	0.303													10	34					0	0	0	0	G	79780824	G	G	79780824	3	3	221	1	0	0	0	0	1	0	0	0	1463	855	30	2	1000	2	BMP2K	4	79780824	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	393407	79780824	111373452	91	40617											
HERC5	51191	broad.mit.edu	37	chr4	89426907	89426907	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgtcctgaaagttggaatGaaagagaccctataagagca	15	8	11	7	0	0	4	0	2	0	2	1	6	1	5	2	1	1	3	2	1	5	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:89426907G>A	uc003hrt.2	+	23	3106	c.2953G>A	c.(2953-2955)GAA>AAA	p.E985K	HERC5_uc011cdm.1_Missense_Mutation_p.E623K	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	985	HECT.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		AAGTTGGAATGAAAGAGACCC	0.338													6	19					0	0	0	0	A	89426907	A	A	89426907	3	1	221	1	0	0	0	0	1	0	0	0	7100	1291	45	2	3043	2	HERC5	4	89426907	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	9646083	89426907	101727369	92	40618											
COL25A1	84570	broad.mit.edu	37	chr4	110222950	110222950	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggtatcaggcagcagatGaatggaaggggcccctttgg	10	7	16	8	0	1	2	1	1	0	1	1	3	1	3	2	6	1	3	2	6	3	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:110222950G>A	uc003hze.1	-	2	757	c.226C>T	c.(226-228)CAT>TAT	p.H76Y	COL25A1_uc003hzg.2_Missense_Mutation_p.H76Y|COL25A1_uc003hzh.1_Missense_Mutation_p.H76Y	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	76	Extracellular (Potential).					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		GGCAGCAGATGAATGGAAGGG	0.572													44	96					0	0	0	0	A	110222950	A	A	110222950	3	1	221	1	0	0	0	0	1	0	0	0	3699	1290	45	2	1966	2	COL25A1	4	110222950	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	20796043	110222950	80931326	93	40619											
GRIA2	2891	broad.mit.edu	37	chr4	158233953	158233953	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtaccgatcactttttcaaGatctggagttaaaaaaggaa	15	12	8	6	1	3	1	2	0	1	1	3	4	3	3	1	2	1	2	1	2	6	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:158233953G>C	uc003ipm.3	+	4	1051	c.592G>C	c.(592-594)GAT>CAT	p.D198H	GRIA2_uc011cit.1_Missense_Mutation_p.D151H|GRIA2_uc003ipl.3_Missense_Mutation_p.D198H|GRIA2_uc003ipk.3_Missense_Mutation_p.D151H|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	198	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	ACTTTTTCAAGATCTGGAGTT	0.388													22	67					0	0	0	0	C	158233953	C	C	158233953	3	2	221	1	0	0	0	0	1	0	0	0	6807	942	33	2	606	2	GRIA2	4	158233953	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	48011003	158233953	32920323	94	40620											
GRIA2	2891	broad.mit.edu	37	chr4	158284166	158284166	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttataaggaaggttacaaCgtatatggcatcgaaagtgt	15	11	10	5	2	0	0	0	0	0	0	1	2	0	1	0	3	2	3	0	3	8	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:158284166C>T	uc003ipm.3	+	15	3081	c.2622C>T	c.(2620-2622)AAC>AAT	p.N874N	GRIA2_uc011cit.1_Silent_p.N827N|GRIA2_uc003ipl.3_Silent_p.N874N|GRIA2_uc003ipk.3_Silent_p.N827N|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_3'UTR|GRIA2_uc011ciy.1_3'UTR|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	874	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AAGGTTACAACGTATATGGCA	0.408													7	92					0	0	0	0	T	158284166	T	T	158284166	2	4	221	1	0	0	0	0	0	0	0	1	6807	535	19	1		1	GRIA2	4	158284166	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	50213	158284166	32870110	95	40621											
KLHL2	11275	broad.mit.edu	37	chr4	166184408	166184408	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgaagaagacttgttgtgaAtttttggaatcccagcttca	11	14	10	6	0	1	4	1	2	0	2	2	5	2	5	1	1	1	2	1	1	4	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:166184408A>G	uc003irb.2	+	5	700	c.441A>G	c.(439-441)GAA>GAG	p.E147E	KLHL2_uc011cjm.1_Silent_p.E151E|KLHL2_uc003irc.2_Silent_p.E59E|KLHL2_uc010ira.2_5'UTR	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	147					intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		CTTGTTGTGAATTTTTGGAAT	0.463													32	61					0	0	0	0	G	166184408	G	G	166184408	2	3	221	1	0	0	0	0	0	0	0	1	8413	98	4	5		5	KLHL2	4	166184408	Silent	SNP	A	TCGA-CV-7099-01A-41D-2012-08	7900242	166184408	24969868	96	40622											
CCDC110	256309	broad.mit.edu	37	chr4	186380966	186380966	+	Missense_Mutation	SNP	C	T	T																															ttcatttgtaagtgccacttCcccatcatgtgacttttgaa																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:186380966C>T	uc003ixu.3	-	6	851	c.775G>A	c.(775-777)GAA>AAA	p.E259K	CCDC110_uc003ixv.3_Missense_Mutation_p.E222K|CCDC110_uc011ckt.1_Missense_Mutation_p.E259K	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	259						nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		AGTGCCACTTCCCCATCATGT	0.363													6	114					0	0	0	0	T	186380966	T	T	186380966	3	4	221	1	0	0	0	0	1	0	0	0	2759	864	30	2	1734	2	CCDC110	4	186380966	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	20196558	186380966	4773310	97	40623	82	2									
CCDC110	256309	broad.mit.edu	37	chr4	186380971	186380971	+	Missense_Mutation	SNP	T	A	A																															ttgtaagtgccacttccccaTcatgtgacttttgaagctct																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:186380971T>A	uc003ixu.3	-	6	846	c.770A>T	c.(769-771)GAT>GTT	p.D257V	CCDC110_uc003ixv.3_Missense_Mutation_p.D220V|CCDC110_uc011ckt.1_Missense_Mutation_p.D257V	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	257						nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		CACTTCCCCATCATGTGACTT	0.358													6	110					0	0	0	0	A	186380971	A	A	186380971	3	1	221	1	0	0	0	0	1	0	0	0	2759	1435	50	5	1739	5	CCDC110	4	186380971	Missense_Mutation	SNP	T	TCGA-CV-7099-01A-41D-2012-08	5	186380971	4773305	98	40624	82	2									
FAT1	2195	broad.mit.edu	37	chr4	187525001	187525001	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttcccaatgacgccacctGagtattcttctccagaagag	10	11	7	13	1	3	4	0	2	3	2	5	4	4	4	4	0	0	1	4	0	3	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:187525001G>C	uc003izf.2	-	19	10867	c.10679C>G	c.(10678-10680)TCA>TGA	p.S3560*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3560	Extracellular (Potential).|Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GACGCCACCTGAGTATTCTTC	0.473										HNSCC(5;0.00058)			12	28					0	0	0	0	C	187525001	C	C	187525001	4	2	221	1	0	0	0	0	0	1	0	0	5721	1294	45	2	3123	2	FAT1	4	187525001	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1144030	187525001	3629275	99	40625											
FAT1	2195	broad.mit.edu	37	chr4	187525110	187525110	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtatgtcaaagatgacaactGaggctttccattatctgcca	12	12	8	9	0	2	3	1	2	1	1	3	3	3	3	2	1	2	2	2	1	4	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr4:187525110G>A	uc003izf.2	-	19	10758	c.10570C>T	c.(10570-10572)CAG>TAG	p.Q3524*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3524	Extracellular (Potential).|Cadherin 32.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GATGACAACTGAGGCTTTCCA	0.378										HNSCC(5;0.00058)			10	25					0	0	0	0	A	187525110	A	A	187525110	4	1	221	1	0	0	0	0	0	1	0	0	5721	1299	45	2	3232	2	FAT1	4	187525110	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	109	187525110	3629166	100	40626											
CEP72	55722	broad.mit.edu	37	chr5	644450	644450	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttagataaatctttggaaGagaacagtaggttaaaatcg	17	12	9	3	1	1	2	0	0	1	2	2	4	1	3	0	2	1	2	0	2	8	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:644450G>C	uc003jbf.2	+	10	1648	c.1576G>C	c.(1576-1578)GAG>CAG	p.E526Q		NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	526	Potential.				G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			ATCTTTGGAAGAGAACAGTAG	0.368													4	107					0	0	0	0	C	644450	C	C	644450	3	2	221	1	0	0	0	0	1	0	0	0	3275	943	33	2	1614	2	CEP72	5	644450	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08		644450	180270810	101	40627											
SLC6A3	6531	broad.mit.edu	37	chr5	1409145	1409145	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcccccggactcaccataGaaccaggccactccgatggc	9	6	8	18	2	1	1	1	0	0	1	3	3	3	2	6	3	1	0	6	3	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:1409145G>A	uc003jck.2	-	11	1615	c.1494C>T	c.(1492-1494)TTC>TTT	p.F498F		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	498	Helical; Name=10; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	ACTCACCATAGAACCAGGCCA	0.582													8	8					0	0	0	0	A	1409145	A	A	1409145	2	1	221	1	0	0	0	0	0	0	0	1	14749	933	33	2		2	SLC6A3	5	1409145	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	764695	1409145	179506115	102	40628											
ADAMTS16	170690	broad.mit.edu	37	chr5	5242298	5242298	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgagtgctccgtgtcctgcGgagggggtaggtgccttcca	4	10	16	11	2	0	1	0	1	0	0	3	2	3	2	4	4	3	2	4	4	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:5242298G>A	uc003jdl.2	+	17	2794	c.2656G>A	c.(2656-2658)GGA>AGA	p.G886R	ADAMTS16_uc003jdk.1_Missense_Mutation_p.G886R	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	886	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CGTGTCCTGCGGAGGGGGTAG	0.612													20	46					0	0	0	0	A	5242298	A	A	5242298	3	1	221	1	0	0	0	0	1	0	0	0	261	1117	39	1	2722	1	ADAMTS16	5	5242298	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	3833153	5242298	175672962	103	40629											
ADCY2	108	broad.mit.edu	37	chr5	7766894	7766894	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatcaggtggcgattctgcGtgcgcagaatttatttttcc	8	15	10	8	3	2	1	1	0	1	1	3	2	3	1	1	2	2	1	1	2	3	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:7766894G>A	uc003jdz.1	+	17	2256	c.2189G>A	c.(2188-2190)CGT>CAT	p.R730H	ADCY2_uc011cmo.1_Missense_Mutation_p.R550H	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	730					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GCGATTCTGCGTGCGCAGAAT	0.428													11	114					0	0	0	0	A	7766894	A	A	7766894	3	1	221	1	0	0	0	0	1	0	0	0	294	1145	40	1	2255	1	ADCY2	5	7766894	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	2524596	7766894	173148366	104	40630											
FASTKD3	79072	broad.mit.edu	37	chr5	7868022	7868022	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaactttttacaatgggcatGatggaatttgaccccgaaag	14	11	9	7	1	0	2	0	2	0	0	0	4	0	3	2	2	2	1	2	2	5	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:7868022G>C	uc003jeb.2	-	2	312	c.175C>G	c.(175-177)CAT>GAT	p.H59D	FASTKD3_uc011cmp.1_Intron|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	59					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						CAATGGGCATGATGGAATTTG	0.438													23	53					0	0	0	0	C	7868022	C	C	7868022	3	2	221	1	0	0	0	0	1	0	0	0	5719	1290	45	2	1837	2	FASTKD3	5	7868022	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	101128	7868022	173047238	105	40631											
TRIO	7204	broad.mit.edu	37	chr5	14381332	14381332	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacccaggagctcctgaaaGagcacgaggagttccagata	14	5	11	11	1	0	3	0	1	0	2	2	6	2	5	3	2	2	3	3	2	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:14381332G>C	uc003jff.2	+	21	3547	c.3541G>C	c.(3541-3543)GAG>CAG	p.E1181Q	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.E1132Q|TRIO_uc003jfh.1_Missense_Mutation_p.E830Q	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1181	Spectrin 4.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GCTCCTGAAAGAGCACGAGGA	0.473													18	45					0	0	0	0	C	14381332	C	C	14381332	3	2	221	1	0	0	0	0	1	0	0	0	16619	943	33	2	3623	2	TRIO	5	14381332	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	6513310	14381332	166533928	106	40632											
TRIO	7204	broad.mit.edu	37	chr5	14387879	14387879	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatatcattccagccagtatCcctggctcagaggtgaaact	11	10	9	11	0	2	2	2	1	0	1	4	3	4	2	3	2	2	2	3	2	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:14387879C>T	uc003jff.2	+	23	3810	c.3804C>T	c.(3802-3804)ATC>ATT	p.I1268I	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.I1219I|TRIO_uc003jfh.1_Silent_p.I917I	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1268					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CAGCCAGTATCCCTGGCTCAG	0.443													4	53					0	0	0	0	T	14387879	T	T	14387879	2	4	221	1	0	0	0	0	0	0	0	1	16619	845	30	2		2	TRIO	5	14387879	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	6547	14387879	166527381	107	40633											
IL7R	3575	broad.mit.edu	37	chr5	35875625	35875625	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatttcaggattaagcctaTcgtatggcccagtctccccg	8	12	9	12	2	2	1	1	1	1	0	4	2	2	2	4	2	1	1	4	2	3	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:35875625T>A	uc003jjs.2	+	7	901	c.812T>A	c.(811-813)ATC>AAC	p.I271N	IL7R_uc011coo.1_Missense_Mutation_p.S240T|IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	271	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ATTAAGCCTATCGTATGGCCC	0.393													13	27					0	0	0	0	A	35875625	A	A	35875625	3	1	221	1	0	0	0	0	1	0	0	0	7744	1435	50	5	838	5	IL7R	5	35875625	Missense_Mutation	SNP	T	TCGA-CV-7099-01A-41D-2012-08	21487746	35875625	145039635	108	40634											
IPO11	51194	broad.mit.edu	37	chr5	61747671	61747671	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttaaagtccaggatgatcttCgacagcacagagcattactt	13	11	8	9	1	1	2	0	1	1	1	3	4	2	3	1	1	3	2	1	1	3	4	rs138490998		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:61747671C>T	uc003jtc.2	+	5	617	c.427C>T	c.(427-429)CGA>TGA	p.R143*	IPO11_uc011cqr.1_Nonsense_Mutation_p.R183*|IPO11_uc003jtb.1_Nonsense_Mutation_p.R143*	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	143	HEAT 1.					cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		GGATGATCTTCGACAGCACAG	0.403													20	55					0	0	0	0	T	61747671	T	T	61747671	4	4	221	1	0	0	0	0	0	1	0	0	7832	876	31	1	565	1	IPO11	5	61747671	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	25872046	61747671	119167589	109	40635											
GPR98	84059	broad.mit.edu	37	chr5	90050870	90050870	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggatattgccattcacttGagagctcaacccaatttctt	10	13	8	10	0	3	1	2	1	1	1	3	3	3	2	2	2	3	1	2	2	3	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:90050870G>C	uc003kju.2	+	55	11544	c.11448G>C	c.(11446-11448)TTG>TTC	p.L3816F	GPR98_uc003kjt.2_Missense_Mutation_p.L1522F|GPR98_uc003kjv.2_Missense_Mutation_p.L1416F	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3816	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCATTCACTTGAGAGCTCAAC	0.358													29	69					0	0	0	0	C	90050870	C	C	90050870	3	2	221	1	0	0	0	0	1	0	0	0	6760	1281	45	2	11666	2	GPR98	5	90050870	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	28303199	90050870	90864390	110	40636											
ERAP2	64167	broad.mit.edu	37	chr5	96248384	96248384	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtgtattctgtgggtgctCagacaacagcaggatggaat	10	12	13	6	0	2	1	1	0	1	1	2	3	2	3	0	3	3	3	0	3	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:96248384C>T	uc003kmq.2	+	16	3108	c.2398C>T	c.(2398-2400)CAG>TAG	p.Q800*	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Nonsense_Mutation_p.Q800*|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Nonsense_Mutation_p.Q749*|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	800	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		TGTGGGTGCTCAGACAACAGC	0.328													16	42					0	0	0	0	T	96248384	T	T	96248384	4	4	221	1	0	0	0	0	0	1	0	0	5228	827	29	2	2456	2	ERAP2	5	96248384	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	6197514	96248384	84666876	111	40637											
SRFBP1	153443	broad.mit.edu	37	chr5	121309963	121309963	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacttgtcaggagtgttggcCgactgaagtcaaaaaagtta	14	10	11	6	1	2	1	2	1	0	0	2	3	2	2	1	2	1	2	1	2	6	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:121309963C>T	uc003kst.1	+	2	181	c.109C>T	c.(109-111)CGA>TGA	p.R37*		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	37					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		GAGTGTTGGCCGACTGAAGTC	0.313													8	16					0	0	0	0	T	121309963	T	T	121309963	4	4	221	1	0	0	0	0	0	1	0	0	15210	644	23	1	115	1	SRFBP1	5	121309963	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	25061579	121309963	59605297	112	40638											
PCDHGA3	56112	broad.mit.edu	37	chr5	140724426	140724426	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacgagggattcaatgctCaagtgtcttatattctagat	11	14	9	7	1	4	2	2	1	2	1	4	4	4	3	0	1	1	1	0	1	5	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:140724426C>A	uc003ljm.1	+	1	826	c.826C>A	c.(826-828)CAA>AAA	p.Q276K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.Q36K|PCDHGA3_uc011dap.1_Missense_Mutation_p.Q276K	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	276	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCAATGCTCAAGTGTCTTA	0.448													16	33					0.000422831	0.00059092	1	0	A	140724426	A	A	140724426	3	1	221	1	0	0	0	0	1	0	0	0	11609	827	29	2	828	2	PCDHGA3	5	140724426	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	19414463	140724426	40190834	113	40639											
PCDHGA10	56106	broad.mit.edu	37	chr5	140794543	140794543	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtggtggcggtggacagaGactccggccagaacgcctgg	8	5	18	10	3	0	2	0	0	0	2	1	4	1	3	3	7	1	0	3	7	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:140794543G>A	uc003lkl.1	+	1	1801	c.1801G>A	c.(1801-1803)GAC>AAC	p.D601N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.D601N|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	601	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGACAGAGACTCCGGCCA	0.716													38	108					0	0	0	0	A	140794543	A	A	140794543	3	1	221	1	0	0	0	0	1	0	0	0	11605	942	33	2	1803	2	PCDHGA10	5	140794543	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	70117	140794543	40120717	114	40640											
NR3C1	2908	broad.mit.edu	37	chr5	142780147	142780147	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctctcccatatacagtccCattgagagtgaaactgcttt	10	13	7	11	0	1	2	0	2	1	1	4	3	3	2	2	0	3	1	2	0	3	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:142780147C>G	uc003lmz.2	-	2	750	c.258G>C	c.(256-258)ATG>ATC	p.M86I	NR3C1_uc003lmy.2_Missense_Mutation_p.M86I|NR3C1_uc003lna.2_Missense_Mutation_p.M86I|NR3C1_uc003lnb.2_Missense_Mutation_p.M86I|NR3C1_uc011dbk.1_Intron|NR3C1_uc003lnc.2_Missense_Mutation_p.M86I|NR3C1_uc003lnd.2_Missense_Mutation_p.M86I|NR3C1_uc003lne.2_Missense_Mutation_p.M86I|NR3C1_uc003lnf.2_Missense_Mutation_p.M86I|NR3C1_uc003lng.2_Missense_Mutation_p.M86I|NR3C1_uc003lnh.2_Missense_Mutation_p.M86I|NR3C1_uc003lni.2_Missense_Mutation_p.M86I	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	86	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	TATACAGTCCCATTGAGAGTG	0.473													4	169					0	0	0	0	G	142780147	G	G	142780147	3	3	221	1	0	0	0	0	1	0	0	0	10684	594	21	4	2162	4	NR3C1	5	142780147	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1985604	142780147	38135113	115	40641											
SLC36A3	285641	broad.mit.edu	37	chr5	150660632	150660632	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacaaacagtgcccagctctCtgacacttgggagatggcaa	12	8	10	11	0	1	2	0	1	1	1	2	3	1	2	1	2	4	2	1	2	3	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:150660632C>T	uc003ltw.2	-	9	1506	c.1087G>A	c.(1087-1089)GAG>AAG	p.E363K	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Missense_Mutation_p.E348K|SLC36A3_uc003ltx.2_Missense_Mutation_p.E404K	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	363	Cytoplasmic (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCCCAGCTCTCTGACACTTGG	0.507													23	43					0	0	0	0	T	150660632	T	T	150660632	3	4	221	1	0	0	0	0	1	0	0	0	14659	922	32	2	333	2	SLC36A3	5	150660632	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	7880485	150660632	30254628	116	40642											
CLINT1	9685	broad.mit.edu	37	chr5	157218825	157218825	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagcccataagatcaaacagGtctgaagaatttgaggcagc	15	7	11	8	0	2	4	1	2	1	2	2	5	2	4	1	2	3	1	1	2	4	2	rs150043675	by1000genomes	TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:157218825G>A	uc003lxj.1	-	10	1456	c.1266C>T	c.(1264-1266)GAC>GAT	p.D422D	CLINT1_uc003lxg.1_5'Flank|CLINT1_uc003lxh.1_5'UTR|CLINT1_uc003lxi.1_Silent_p.D404D|CLINT1_uc011ddv.1_Silent_p.D422D	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	422				D->R: Strongly decreases clathrin binding.	endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GATCAAACAGGTCTGAAGAAT	0.502													8	92					0	0	0	0	A	157218825	A	A	157218825	2	1	221	1	0	0	0	0	0	0	0	1	3546	1252	44	4		4	CLINT1	5	157218825	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	6558193	157218825	23696435	117	40643											
STK10	6793	broad.mit.edu	37	chr5	171534828	171534828	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcgtttctgtagagtcttCagattcttggcagacacacc	8	14	8	11	1	5	3	1	0	4	3	6	3	5	3	1	1	0	3	1	1	1	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:171534828C>G	uc003mbo.1	-	5	849	c.549G>C	c.(547-549)CTG>CTC	p.L183L		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	183	Protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GTAGAGTCTTCAGATTCTTGG	0.478											OREG0017039	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	33					0	0	0	0	G	171534828	G	G	171534828	2	3	221	1	0	0	0	0	0	0	0	1	15352	813	29	2		2	STK10	5	171534828	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	14316003	171534828	9380432	118	40644											
FGFR4	2264	broad.mit.edu	37	chr5	176523644	176523644	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctatgggagatcttcaccctCgggggctccccgtatcctgg	5	10	12	14	2	2	1	1	0	1	1	5	2	4	1	4	4	0	2	4	4	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr5:176523644C>T	uc003mfl.2	+	16	2222	c.2055C>T	c.(2053-2055)CTC>CTT	p.L685L	FGFR4_uc003mfm.2_Silent_p.L685L|FGFR4_uc011dfu.1_Silent_p.L617L|FGFR4_uc003mfo.2_Silent_p.L645L	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	685	Protein kinase.|Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	TCTTCACCCTCGGGGGCTCCC	0.667										TSP Lung(9;0.080)			13	33					0	0	0	0	T	176523644	T	T	176523644	2	4	221	1	0	0	0	0	0	0	0	1	5900	871	31	1		1	FGFR4	5	176523644	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	4988816	176523644	4391616	119	40645											
DSP	1832	broad.mit.edu	37	chr6	7586033	7586033	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggtcccgcagtgggtcccgGagaggaagctttgacgccac	7	6	16	12	3	0	2	0	1	0	1	2	4	2	3	3	4	1	2	3	4	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:7586033G>A	uc003mxp.1	+	24	8817	c.8538G>A	c.(8536-8538)CGG>CGA	p.R2846R	DSP_uc003mxq.1_Silent_p.R2247R	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2846	6 X 4 AA tandem repeats of G-S-R-[SR].|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GTGGGTCCCGGAGAGGAAGCT	0.373													39	119					0	0	0	0	A	7586033	A	A	7586033	2	1	221	1	0	0	0	0	0	0	0	1	4803	1161	41	2		2	DSP	6	7586033	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08		7586033	163529034	120	40646											
NHLRC1	378884	broad.mit.edu	37	chr6	18122513	18122513	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgagggctccgggggcgcTgggggcggcgcgatgggcgg	2	4	26	9	6	0	1	0	1	0	0	1	2	1	1	1	9	0	2	1	9	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:18122513T>A	uc003ncl.1	-	1	339	c.325A>T	c.(325-327)AGC>TGC	p.S109C		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	109					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			CCGGGGGCGCTGGGGGCGGCG	0.731													7	20					0	0	0	0	A	18122513	A	A	18122513	3	1	221	1	0	0	0	0	1	0	0	0	10459	1580	55	5	866	5	NHLRC1	6	18122513	Missense_Mutation	SNP	T	TCGA-CV-7099-01A-41D-2012-08	10536480	18122513	152992554	121	40647											
NHLRC1	378884	broad.mit.edu	37	chr6	18122525	18122525	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggggcgctgggggcggcgcGatgggcggccggggactggc	2	3	26	10	6	0	0	0	0	0	0	0	2	0	1	1	10	0	1	1	10	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:18122525G>A	uc003ncl.1	-	1	327	c.313C>T	c.(313-315)CGC>TGC	p.R105C		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	105					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			GGGGCGGCGCGATGGGCGGCC	0.726													5	15					0	0	0	0	A	18122525	A	A	18122525	3	1	221	1	0	0	0	0	1	0	0	0	10459	1058	37	1	878	1	NHLRC1	6	18122525	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	12	18122525	152992542	122	40648											
HIST1H2BB	3018	broad.mit.edu	37	chr6	26043802	26043802	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcggctgcgcttacgcttCttaccatccttcttctgcgc	3	15	8	15	4	3	0	0	0	3	0	4	0	4	0	2	1	5	3	2	1	2	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:26043802C>T	uc003nfu.2	-	1	84	c.84G>A	c.(82-84)AAG>AAA	p.K28K	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	28					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCTTACGCTTCTTACCATCCT	0.507													45	128					0	0	0	0	T	26043802	T	T	26043802	2	4	221	1	0	0	0	0	0	0	0	1	7180	912	32	2		2	HIST1H2BB	6	26043802	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	7921277	26043802	145071265	123	40649											
HIST1H3I	8354	broad.mit.edu	37	chr6	27839926	27839926	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attagcagctcggtcgacttCtggtagcggcggatctcgcg	6	10	14	11	6	2	0	0	0	2	0	5	2	2	1	0	4	3	3	0	4	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:27839926C>T	uc003njy.2	-	1	174	c.168G>A	c.(166-168)CAG>CAA	p.Q56Q		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	56					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						CGGTCGACTTCTGGTAGCGGC	0.657													37	68					0	0	0	0	T	27839926	T	T	27839926	2	4	221	1	0	0	0	0	0	0	0	1	7202	912	32	2		2	HIST1H3I	6	27839926	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1796124	27839926	143275141	124	40650											
HLA-A	3105	broad.mit.edu	37	chr6	29910684	29910684	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggagccgcgggcgccgtGgatagagcaggaggggccgg	7	3	22	9	5	0	1	0	0	0	1	0	5	0	4	3	7	2	1	3	7	1	1	rs41542016		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:29910684G>A	uc003nol.2	+	2	224	c.224G>A	c.(223-225)TGG>TAG	p.W75*	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Nonsense_Mutation_p.W75*|HLA-A_uc003noo.2_Nonsense_Mutation_p.W75*|HLA-A_uc010jrr.2_Nonsense_Mutation_p.W75*|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_Nonsense_Mutation_p.W47*|HLA-A_uc011dmc.1_5'UTR|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	75	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CGGGCGCCGTGGATAGAGCAG	0.677									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			3	17					0	0	0	0	A	29910684	A	A	29910684	4	1	221	1	0	0	0	0	0	1	0	0	7234	1357	47	4	230	4	HLA-A	6	29910684	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	2070758	29910684	141204383	125	40651											
MDC1	9656	broad.mit.edu	37	chr6	30671427	30671427	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctggcttctctgcagtatCttcttcctcttccttgataa	5	17	5	14	0	4	1	0	1	4	0	7	1	6	1	3	1	1	3	3	1	2	7			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:30671427C>T	uc003nrg.3	-	10	5973	c.5533G>A	c.(5533-5535)GAT>AAT	p.D1845N	MDC1_uc003nrf.3_Missense_Mutation_p.D476N|MDC1_uc011dmp.1_Missense_Mutation_p.D1452N	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1845	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TCTGCAGTATCTTCTTCCTCT	0.483								Other_conserved_DNA_damage_response_genes					59	143					0	0	0	0	T	30671427	T	T	30671427	3	4	221	1	0	0	0	0	1	0	0	0	9456	913	32	2	760	2	MDC1	6	30671427	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	760743	30671427	140443640	126	40652											
MUC21	394263	broad.mit.edu	37	chr6	30954680	30954680	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccagcacagccaccaactCtgagtccagcacaccctcca	11	4	7	19	0	1	1	0	1	1	0	3	1	3	1	6	1	4	2	6	1	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:30954680C>G	uc003nsh.2	+	2	979	c.728C>G	c.(727-729)TCT>TGT	p.S243C	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	243	Ser-rich.|28 X 15 AA approximate tandem repeats.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GCCACCAACTCTGAGTCCAGC	0.642													7	305					0	0	0	0	G	30954680	G	G	30954680	3	3	221	1	0	0	0	0	1	0	0	0	10030	913	32	2	734	2	MUC21	6	30954680	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	283253	30954680	140160387	127	40653											
HLA-B	3106	broad.mit.edu	37	chr6	31323241	31323241	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccacaagctcagtgtcctGagtttggtcctcgccatccc	6	11	8	16	1	1	1	1	1	0	0	6	1	5	1	5	1	1	2	5	1	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:31323241G>C	uc003nth.2	-	4	802	c.748C>G	c.(748-750)CAG>GAG	p.Q250E	HLA-C_uc003ntb.2_RNA|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_RNA|HLA-B_uc011dnk.1_RNA|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Missense_Mutation_p.Q129E|HLA-B_uc003nti.1_RNA|HLA-B_uc010jsn.1_RNA	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	250	Alpha-3.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						TCAGTGTCCTGAGTTTGGTCC	0.587									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				29	65					0	0	0	0	C	31323241	C	C	31323241	3	2	221	1	0	0	0	0	1	0	0	0	7235	1299	45	2	356	2	HLA-B	6	31323241	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	368561	31323241	139791826	128	40654											
HLA-B	3106	broad.mit.edu	37	chr6	31324637	31324637	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcgtcgctgtcgaacctcacGaactgggtgtcgtccacgta	7	9	12	13	6	1	0	1	0	0	0	5	2	2	0	2	1	2	2	2	1	3	1	rs41546213		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:31324637G>C	uc003nth.2	-	2	225	c.171C>G	c.(169-171)TTC>TTG	p.F57L	HLA-C_uc003ntb.2_5'Flank|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_5'Flank|HLA-B_uc011dnk.1_5'Flank|HLA-B_uc003ntf.2_Missense_Mutation_p.F57L|HLA-B_uc003ntg.1_5'Flank|HLA-B_uc003nti.1_5'Flank|HLA-B_uc010jsn.1_5'Flank|HLA-B_uc010jso.2_Missense_Mutation_p.F29L	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	57	Alpha-1.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						CGAACCTCACGAACTGGGTGT	0.657									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				11	18					0	0	0	0	C	31324637	C	C	31324637	3	2	221	1	0	0	0	0	1	0	0	0	7235	1049	37	3	941	3	HLA-B	6	31324637	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1396	31324637	139790430	129	40655											
PACSIN1	29993	broad.mit.edu	37	chr6	34498110	34498110	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccgcagcaccagtggcccCggcatgcccatgaactggcc	7	6	11	17	2	0	1	0	1	0	0	1	1	1	1	6	3	3	3	6	3	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:34498110C>T	uc003ojo.2	+	7	1085	c.879C>T	c.(877-879)CCC>CCT	p.P293P	PACSIN1_uc003ojp.2_Silent_p.P293P	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	293					endocytosis		protein kinase activity				0						CCAGTGGCCCCGGCATGCCCA	0.617													16	27					0	0	0	0	T	34498110	T	T	34498110	2	4	221	1	0	0	0	0	0	0	0	1	11428	639	23	1		1	PACSIN1	6	34498110	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	3173473	34498110	136616957	130	40656											
LRFN2	57497	broad.mit.edu	37	chr6	40359796	40359796	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acagagaggctgcgcttcgtCcagatgttcgagaccttccg	8	9	12	12	4	0	3	0	0	0	3	4	5	2	3	3	1	1	3	3	1	0	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:40359796C>G	uc003oph.1	-	3	2721	c.2256G>C	c.(2254-2256)TGG>TGC	p.W752C		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	752	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGCGCTTCGTCCAGATGTTCG	0.642													11	24					0	0	0	0	G	40359796	G	G	40359796	3	3	221	1	0	0	0	0	1	0	0	0	8988	856	30	2	117	2	LRFN2	6	40359796	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	5861686	40359796	130755271	131	40657											
GPR115	221393	broad.mit.edu	37	chr6	47680160	47680160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctgcatattctagactttcGagctccagagaccattgaga	11	12	8	10	1	2	3	0	1	2	3	4	6	3	3	2	0	2	2	2	0	2	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:47680160G>A	uc003oza.1	+	5	626	c.368G>A	c.(367-369)CGA>CAA	p.R123Q	GPR115_uc003oyz.1_Missense_Mutation_p.R180Q|GPR115_uc003ozb.1_Missense_Mutation_p.R121Q	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	123	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						CTAGACTTTCGAGCTCCAGAG	0.418													30	74					0	0	0	0	A	47680160	A	A	47680160	3	1	221	1	0	0	0	0	1	0	0	0	6670	1058	37	1	382	1	GPR115	6	47680160	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	7320364	47680160	123434907	132	40658											
SMAP1	60682	broad.mit.edu	37	chr6	71442124	71442124	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attggtgtgtttatttgcatCagatgtgctggaattcatag	9	17	11	4	0	2	1	2	0	0	1	2	2	2	2	0	2	2	3	0	2	3	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:71442124C>T	uc003pfr.2	+	2	410	c.162C>T	c.(160-162)ATC>ATT	p.I54I	SMAP1_uc011dxy.1_RNA|SMAP1_uc003pfs.2_Silent_p.I54I|SMAP1_uc010kao.2_Silent_p.I54I|SMAP1_uc010kap.2_Silent_p.I44I	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	stromal membrane-associated GTPase-activating	54	C4-type.|Arf-GAP.				regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding				0						TTATTTGCATCAGATGTGCTG	0.363													12	54					0	0	0	0	T	71442124	T	T	71442124	2	4	221	1	0	0	0	0	0	0	0	1	14830	816	29	2		2	SMAP1	6	71442124	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	23761964	71442124	99672943	133	40659											
IMPG1	3617	broad.mit.edu	37	chr6	76660391	76660391	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaagaacactaccagctctCggcccttgggggcaatggtc	9	8	12	12	1	1	2	0	1	1	1	3	2	1	2	2	4	3	2	2	4	4	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:76660391C>T	uc003pik.1	-	13	1842	c.1712G>A	c.(1711-1713)CGA>CAA	p.R571Q		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	571	SEA 2.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TACCAGCTCTCGGCCCTTGGG	0.488													8	56					0	0	0	0	T	76660391	T	T	76660391	3	4	221	1	0	0	0	0	1	0	0	0	7767	884	31	1	701	1	IMPG1	6	76660391	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	5218267	76660391	94454676	134	40660											
WASF1	8936	broad.mit.edu	37	chr6	110423089	110423089	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtggatgaactggtacagtCtcacatactggggcagctct	10	10	12	9	0	2	1	1	1	2	0	3	2	2	2	0	4	4	3	0	4	3	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:110423089C>T	uc003ptv.1	-	10	2061	c.1224G>A	c.(1222-1224)GAG>GAA	p.E408E	WASF1_uc003ptw.1_Silent_p.E408E|WASF1_uc003ptx.1_Silent_p.E408E|WASF1_uc003pty.1_Silent_p.E408E	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	408					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		CTGGTACAGTCTCACATACTG	0.577													13	44					0	0	0	0	T	110423089	T	T	110423089	2	4	221	1	0	0	0	0	0	0	0	1	17320	912	32	2		2	WASF1	6	110423089	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	33762698	110423089	60691978	135	40661											
OLIG3	167826	broad.mit.edu	37	chr6	137815023	137815023	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctaggttcaggtcgtgcatCcgcttgcgttcgcgtccgtt	3	13	13	12	6	1	0	1	0	0	0	5	0	3	0	2	2	2	6	2	2	1	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:137815023C>T	uc003qhp.1	-	1	509	c.285G>A	c.(283-285)CGG>CGA	p.R95R		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	95	Basic motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		GGTCGTGCATCCGCTTGCGTT	0.607													36	58					0	0	0	0	T	137815023	T	T	137815023	2	4	221	1	0	0	0	0	0	0	0	1	10916	842	30	2		2	OLIG3	6	137815023	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	27391934	137815023	33300044	136	40662											
RAET1E	135250	broad.mit.edu	37	chr6	150210518	150210518	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgcctcccagtgccctaaGaattccctgagccagtgatc	9	10	8	14	0	0	3	0	2	0	1	3	3	2	3	5	0	3	0	5	0	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:150210518G>A	uc003qnl.1	-	3	648	c.588C>T	c.(586-588)TTC>TTT	p.F196F	uc003qni.1_Intron|RAET1E_uc003qnj.2_Silent_p.F196F|RAET1E_uc003qnk.1_Silent_p.F160F|RAET1E_uc010kih.1_RNA	NM_139165	NP_631904	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E precursor	196	Extracellular (Potential).|MHC class I alpha-2 like.				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		AGTGCCCTAAGAATTCCCTGA	0.512													5	66					0	0	0	0	A	150210518	A	A	150210518	2	1	221	1	0	0	0	0	0	0	0	1	13064	933	33	2		2	RAET1E	6	150210518	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	12395495	150210518	20904549	137	40663											
RAET1E	135250	broad.mit.edu	37	chr6	150210686	150210686	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatttctctccattggtggcGaactgccaggatgcaccagt	8	11	11	11	1	1	0	0	0	1	0	3	3	2	1	3	3	3	1	3	3	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr6:150210686G>A	uc003qnl.1	-	3	480	c.420C>T	c.(418-420)TTC>TTT	p.F140F	uc003qni.1_Intron|RAET1E_uc003qnj.2_Silent_p.F140F|RAET1E_uc003qnk.1_Silent_p.F104F|RAET1E_uc010kih.1_RNA	NM_139165	NP_631904	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E precursor	140	Extracellular (Potential).|MHC class I alpha-2 like.				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		CATTGGTGGCGAACTGCCAGG	0.468													5	75					0	0	0	0	A	150210686	A	A	150210686	2	1	221	1	0	0	0	0	0	0	0	1	13064	1049	37	1		1	RAET1E	6	150210686	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	168	150210686	20904381	138	40664											
PSMG3	84262	broad.mit.edu	37	chr7	1608785	1608785	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgccccagaaggacttttGtggtgagcacaggcttgctg	7	10	13	11	0	0	2	0	1	0	1	0	3	0	3	3	3	3	3	3	3	1	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:1608785G>C	uc003skx.2	-	1	845	c.191C>G	c.(190-192)ACA>AGA	p.T64R	PSMG3_uc011jvx.1_Missense_Mutation_p.T64R|KIAA1908_uc003sla.2_5'Flank|KIAA1908_uc003sky.1_5'Flank|KIAA1908_uc003skz.1_5'Flank	NM_032302	NP_115678	Q9BT73	PSMG3_HUMAN	proteasome assembling chaperone 3	64											0		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.63e-15)		AAGGACTTTTGTGGTGAGCAC	0.403													29	69					0	0	0	0	C	1608785	C	C	1608785	3	2	221	1	0	0	0	0	1	0	0	0	12775	1377	48	4	185	4	PSMG3	7	1608785	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08		1608785	157529878	139	40665											
THSD7A	221981	broad.mit.edu	37	chr7	11485796	11485796	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgatgtctccttgtacttTcattcccagcaacacttcca	8	15	4	14	0	2	1	1	1	1	0	5	1	4	1	3	0	3	2	3	0	2	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:11485796T>C	uc003ssf.3	-	13	3208	c.2956A>G	c.(2956-2958)AAA>GAA	p.K986E		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	986	TSP type-1 10.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCTTGTACTTTCATTCCCAGC	0.433										HNSCC(18;0.044)			3	187					0	0	0	0	C	11485796	C	C	11485796	3	2	221	1	0	0	0	0	1	0	0	0	15945	1792	62	5	2077	5	THSD7A	7	11485796	Missense_Mutation	SNP	T	TCGA-CV-7099-01A-41D-2012-08	9877011	11485796	147652867	140	40666											
ETV1	2115	broad.mit.edu	37	chr7	13975358	13975358	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccatggggtagctgctatCtggtatggactgcgatggag	7	11	16	7	1	1	0	0	0	1	0	2	3	2	2	1	5	3	4	1	5	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:13975358C>A	uc011jxq.1	-	8	1268	c.529G>T	c.(529-531)GAT>TAT	p.D177Y	ETV1_uc011jxn.1_Missense_Mutation_p.D137Y|ETV1_uc011jxo.1_Intron|ETV1_uc011jxp.1_Missense_Mutation_p.D119Y|ETV1_uc003ssw.3_Missense_Mutation_p.D177Y|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.D159Y|ETV1_uc011jxs.1_Missense_Mutation_p.D159Y|ETV1_uc010ktv.2_Missense_Mutation_p.D46Y	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	177					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						TAGCTGCTATCTGGTATGGAC	0.478			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								12	168					6.72482e-11	9.73466e-11	1	0	A	13975358	A	A	13975358	3	1	221	1	0	0	0	0	1	0	0	0	5301	913	32	2	932	2	ETV1	7	13975358	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2489562	13975358	145163305	141	40667											
HOXA11	3207	broad.mit.edu	37	chr7	27222479	27222479	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taatttttttttccttcattCtcctgttctgaaaccagatt	8	21	3	9	0	3	2	1	1	2	1	5	2	4	2	3	0	1	1	3	0	2	9			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:27222479C>T	uc003syx.2	-	2	950	c.878G>A	c.(877-879)AGA>AAA	p.R293K	HOXA10_uc003syw.3_5'Flank|HOXA11_uc003syy.2_RNA|HOXA11AS_uc003syz.1_5'Flank	NM_005523	NP_005514	P31270	HXA11_HUMAN	homeobox A11	293	Homeobox.				branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)	2						TTCCTTCATTCTCCTGTTCTG	0.453			T	NUP98	CML								27	64					0	0	0	0	T	27222479	T	T	27222479	3	4	221	1	0	0	0	0	1	0	0	0	7329	913	32	2	67	2	HOXA11	7	27222479	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	13247121	27222479	131916184	142	40668											
ABCA13	154664	broad.mit.edu	37	chr7	48318519	48318519	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgaaagaaatagctactttAaaaaaaatagatcatttcac	20	11	5	5	0	2	3	2	1	0	2	2	3	2	3	0	0	2	1	0	0	9	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:48318519A>T	uc003toq.2	+	18	7753	c.7728A>T	c.(7726-7728)TTA>TTT	p.L2576F	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2576					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TAGCTACTTTAAAAAAAATAG	0.313													42	75					0	0	0	0	T	48318519	T	T	48318519	3	4	221	1	0	0	0	0	1	0	0	0	31	359	13	5	7627	5	ABCA13	7	48318519	Missense_Mutation	SNP	A	TCGA-CV-7099-01A-41D-2012-08	21096040	48318519	110820144	143	40669											
IKZF1	10320	broad.mit.edu	37	chr7	50467665	50467665	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacagcagcgccagctacgaGaaggagaacgaaatgatgaa	17	3	13	8	3	0	4	0	2	0	2	0	8	0	4	1	1	5	2	1	1	5	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:50467665G>A	uc003tow.3	+	9	1068	c.900G>A	c.(898-900)GAG>GAA	p.E300E	IKZF1_uc003tox.3_Silent_p.E258E|IKZF1_uc003toy.3_Silent_p.E258E|IKZF1_uc011kck.1_Silent_p.E213E|IKZF1_uc003toz.3_Silent_p.E270E|IKZF1_uc010kyx.2_Silent_p.E40E|IKZF1_uc003tpa.3_Silent_p.E42E	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	300					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CCAGCTACGAGAAGGAGAACG	0.637			D		ALL								4	20					0	0	0	0	A	50467665	A	A	50467665	2	1	221	1	0	0	0	0	0	0	0	1	7653	933	33	2		2	IKZF1	7	50467665	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	2149146	50467665	108670998	144	40670											
ABCB1	5243	broad.mit.edu	37	chr7	87179526	87179526	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tagagcctctgcatcagctgGactgttgtgctcttcccaca	7	12	9	13	0	3	1	1	0	2	1	4	2	4	2	2	1	4	4	2	1	1	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:87179526G>C	uc003uiz.1	-	13	1729	c.1311C>G	c.(1309-1311)GTC>GTG	p.V437V	ABCB1_uc011khc.1_Silent_p.V373V	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	437	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GCATCAGCTGGACTGTTGTGC	0.557													3	48					0	0	0	0	C	87179526	C	C	87179526	2	2	221	1	0	0	0	0	0	0	0	1	40	1161	41	2		2	ABCB1	7	87179526	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	36711861	87179526	71959137	145	40671											
MCM7	4176	broad.mit.edu	37	chr7	99693502	99693502	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgctccaggctgcggcgaGggttgtagcgcccgtaggca	5	8	16	12	4	1	0	0	0	1	0	2	1	2	0	2	4	3	6	2	4	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:99693502G>C	uc003usw.1	-	11	2000	c.1490C>G	c.(1489-1491)CCT>CGT	p.P497R	MCM7_uc003usv.1_Missense_Mutation_p.P321R|MCM7_uc003usx.1_Missense_Mutation_p.P321R|uc003usy.1_5'Flank|MIR25_hsa-mir-25|MI0000082_5'Flank|uc003usz.1_5'Flank|MIR93_hsa-mir-93|MI0000095_5'Flank|uc003uta.1_5'Flank|MIR106B_hsa-mir-106b|MI0000734_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	497	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	GCTGCGGCGAGGGTTGTAGCG	0.622													34	67					0	0	0	0	C	99693502	C	C	99693502	3	2	221	1	0	0	0	0	1	0	0	0	9445	1000	35	4	689	4	MCM7	7	99693502	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	12513976	99693502	59445161	146	40672											
C7orf51	222950	broad.mit.edu	37	chr7	100085946	100085946	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgcctcactagggggtcccGagtagctggggaccctgatg	6	7	16	12	2	1	1	1	1	0	0	2	3	2	2	3	4	1	2	3	4	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:100085946G>A	uc003uvd.1	+	4	761	c.602G>A	c.(601-603)CGA>CAA	p.R201Q	C7orf51_uc003uve.1_5'UTR	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	201										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGGGGGTCCCGAGTAGCTGGG	0.632													34	83					0	0	0	0	A	100085946	A	A	100085946	3	1	221	1	0	0	0	0	1	0	0	0	2411	1058	37	1	612	1	C7orf51	7	100085946	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	392444	100085946	59052717	147	40673											
ACTL6B	51412	broad.mit.edu	37	chr7	100253069	100253069	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccattcttgaggggcgacatGacctccgctccatcccgagg	7	8	11	15	3	1	2	0	2	1	0	4	4	4	2	5	3	0	1	5	3	0	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:100253069G>A	uc003uvy.2	-	3	350	c.243C>T	c.(241-243)GTC>GTT	p.V81V	ACTL6B_uc003uvz.2_RNA|uc003uwa.1_5'Flank	NM_016188	NP_057272	O94805	ACL6B_HUMAN	actin-like 6B	81	Essential for mediating its function in dendritic development; may contribute to neuronal-specific targeting (By similarity).				chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			ovary(1)	1	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GGGGCGACATGACCTCCGCTC	0.612													29	74					0	0	0	0	A	100253069	A	A	100253069	2	1	221	1	0	0	0	0	0	0	0	1	199	1277	45	2		2	ACTL6B	7	100253069	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	167123	100253069	58885594	148	40674											
CUL1	8454	broad.mit.edu	37	chr7	148427271	148427271	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcagattggcctggaccaGatctgggacgacctcagagc	11	6	13	11	1	2	3	1	0	1	3	2	6	2	5	3	3	2	1	3	3	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:148427271G>A	uc010lpg.2	+	2	583	c.57G>A	c.(55-57)CAG>CAA	p.Q19Q	CUL1_uc003wey.2_Silent_p.Q19Q|CUL1_uc003wez.2_5'UTR	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	19					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GCCTGGACCAGATCTGGGACG	0.562													23	59					0	0	0	0	A	148427271	A	A	148427271	2	1	221	1	0	0	0	0	0	0	0	1	4071	933	33	2		2	CUL1	7	148427271	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	48174202	148427271	10711392	149	40675											
CUL1	8454	broad.mit.edu	37	chr7	148484186	148484186	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acagtgcaagtgacgatgccGaagccagcatgatctccaag	13	6	11	11	2	1	2	0	2	1	0	2	4	1	2	3	0	4	2	3	0	3	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:148484186G>A	uc010lpg.2	+	13	1979	c.1453G>A	c.(1453-1455)GAA>AAA	p.E485K	CUL1_uc003wey.2_Missense_Mutation_p.E485K|CUL1_uc003wez.2_Missense_Mutation_p.E375K|CUL1_uc003wfa.2_Missense_Mutation_p.E146K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	485					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TGACGATGCCGAAGCCAGCAT	0.398													66	17					0	0	0	0	A	148484186	A	A	148484186	3	1	221	1	0	0	0	0	1	0	0	0	4071	1059	37	1	1499	1	CUL1	7	148484186	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	56915	148484186	10654477	150	40676											
PRKAG2	51422	broad.mit.edu	37	chr7	151262822	151262822	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacctgactcatccacaacAggcagagctgatattcgtct	13	9	7	12	1	2	3	1	2	1	1	4	3	3	3	2	1	3	2	2	1	3	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:151262822A>T	uc003wkk.2	-	12	1994	c.1383T>A	c.(1381-1383)CCT>CCA	p.P461P	PRKAG2_uc003wki.2_Silent_p.P220P|PRKAG2_uc011kvl.1_Silent_p.P336P|PRKAG2_uc003wkj.2_Silent_p.P417P|PRKAG2_uc003wkl.2_Intron	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	461	CBS 3.				ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CATCCACAACAGGCAGAGCTG	0.433													24	73					0	0	0	0	T	151262822	T	T	151262822	2	4	221	1	0	0	0	0	0	0	0	1	12563	175	7	5		5	PRKAG2	7	151262822	Silent	SNP	A	TCGA-CV-7099-01A-41D-2012-08	2778636	151262822	7875841	151	40677											
WDR60	55112	broad.mit.edu	37	chr7	158679719	158679719	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttgctttccaggcatgctGagaatttagtaaggaatcat	11	14	10	6	0	1	1	1	1	0	1	2	3	2	2	1	2	2	5	1	2	4	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr7:158679719G>C	uc003woe.3	+	7	1101	c.943G>C	c.(943-945)GAG>CAG	p.E315Q	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_5'UTR	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	315										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		CAGGCATGCTGAGAATTTAGT	0.313													34	13					0	0	0	0	C	158679719	C	C	158679719	3	2	221	1	0	0	0	0	1	0	0	0	17379	1291	45	2	969	2	WDR60	7	158679719	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	7416897	158679719	458944	152	40678											
NEIL2	252969	broad.mit.edu	37	chr8	11637314	11637314	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagggcgaggatgattctGagtatttggagagagacgcc	10	8	15	8	2	1	4	0	2	1	2	1	8	1	5	2	3	0	1	2	3	1	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:11637314G>C	uc003wug.2	+	3	1021	c.346G>C	c.(346-348)GAG>CAG	p.E116Q	NEIL2_uc003wue.2_Missense_Mutation_p.E116Q|NEIL2_uc003wuf.2_Missense_Mutation_p.E55Q|NEIL2_uc011kxd.1_Intron	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	116					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		GGATGATTCTGAGTATTTGGA	0.602								BER_DNA_glycosylases					31	48					0	0	0	0	C	11637314	C	C	11637314	3	2	221	1	0	0	0	0	1	0	0	0	10373	1291	45	2	357	2	NEIL2	8	11637314	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08		11637314	134726708	153	40679											
TEX15	56154	broad.mit.edu	37	chr8	30699749	30699749	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagctgtaaaatcttccttCtgttatacagcatttggcat	10	16	6	9	0	3	0	1	0	2	0	4	0	4	0	1	1	3	5	1	1	4	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:30699749C>T	uc003xil.2	-	1	6785	c.6785G>A	c.(6784-6786)AGA>AAA	p.R2262K		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2262										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AATCTTCCTTCTGTTATACAG	0.303													23	52					0	0	0	0	T	30699749	T	T	30699749	3	4	221	1	0	0	0	0	1	0	0	0	15845	913	32	2	1600	2	TEX15	8	30699749	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	19062435	30699749	115664273	154	40680											
GPR124	25960	broad.mit.edu	37	chr8	37696479	37696479	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgccctttcccaggagctGagcgcctttcccagggaggt	5	9	12	15	1	0	1	0	1	0	0	2	3	2	3	5	3	3	1	5	3	0	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:37696479G>C	uc003xkj.2	+	15	2628	c.2265G>C	c.(2263-2265)CTG>CTC	p.L755L	GPR124_uc010lvy.2_Silent_p.L538L	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	755	GPS.|Extracellular (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CCCAGGAGCTGAGCGCCTTTC	0.677													14	57					0	0	0	0	C	37696479	C	C	37696479	2	2	221	1	0	0	0	0	0	0	0	1	6676	1277	45	2		2	GPR124	8	37696479	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	6996730	37696479	108667543	155	40681											
DNAJC5B	85479	broad.mit.edu	37	chr8	66992626	66992626	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctaggccctgtttgtcatCgttggcctcttgacgggctg	3	13	12	13	2	2	1	1	1	1	0	3	1	2	1	3	3	0	3	3	3	1	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:66992626C>T	uc003xvs.1	+	5	639	c.348C>T	c.(346-348)ATC>ATT	p.I116I	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	116					protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			TGTTTGTCATCGTTGGCCTCT	0.423													24	58					0	0	0	0	T	66992626	T	T	66992626	2	4	221	1	0	0	0	0	0	0	0	1	4673	874	31	1		1	DNAJC5B	8	66992626	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	29296147	66992626	79371396	156	40682											
CNGB3	54714	broad.mit.edu	37	chr8	87623893	87623893	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcataaatcatctgtgtatCacaaccctatataaaaagaa	18	11	4	8	0	4	1	3	0	1	1	4	1	4	1	1	0	1	1	1	0	10	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:87623893C>G	uc003ydx.2	-	14	1631	c.1585G>C	c.(1585-1587)GAT>CAT	p.D529H	CNGB3_uc010maj.2_Missense_Mutation_p.D391H	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	529	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						ATCTGTGTATCACAACCCTAT	0.294													10	34					0	0	0	0	G	87623893	G	G	87623893	3	3	221	1	0	0	0	0	1	0	0	0	3616	826	29	2	864	2	CNGB3	8	87623893	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	20631267	87623893	58740129	157	40683											
NECAB1	64168	broad.mit.edu	37	chr8	91940500	91940500	+	Silent	SNP	G	A	A																															acccagataaatagactccaGaaattaattgatagactgga																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:91940500G>A	uc011lgg.1	+	8	860	c.666G>A	c.(664-666)CAG>CAA	p.Q222Q		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	222	Potential.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			ATAGACTCCAGAAATTAATTG	0.383													32	52					0	0	0	0	A	91940500	A	A	91940500	2	1	221	1	0	0	0	0	0	0	0	1	10358	933	33	2		2	NECAB1	8	91940500	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4316607	91940500	54423522	158	40684	83	2									
NECAB1	64168	broad.mit.edu	37	chr8	91940510	91940510	+	Missense_Mutation	SNP	G	C	C																															atagactccagaaattaattGatagactggaaaagaaggta																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:91940510G>C	uc011lgg.1	+	8	870	c.676G>C	c.(676-678)GAT>CAT	p.D226H		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	226	Potential.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			GAAATTAATTGATAGACTGGA	0.383													29	51					0	0	0	0	C	91940510	C	C	91940510	3	2	221	1	0	0	0	0	1	0	0	0	10358	1290	45	2	706	2	NECAB1	8	91940510	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	10	91940510	54423512	159	40685	83	2									
MATN2	4147	broad.mit.edu	37	chr8	98943558	98943558	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgtgacagatgggagacctCaggactccgtggccgaggtg	8	7	16	10	3	1	3	1	1	0	2	3	6	2	4	3	4	0	0	3	4	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:98943558C>T	uc003yic.2	+	3	751	c.520C>T	c.(520-522)CAG>TAG	p.Q174*	MATN2_uc003yib.1_Nonsense_Mutation_p.Q174*|MATN2_uc010mbh.1_Nonsense_Mutation_p.Q174*|MATN2_uc003yid.2_Nonsense_Mutation_p.Q174*|MATN2_uc003yie.1_Nonsense_Mutation_p.Q174*|MATN2_uc010mbi.1_Nonsense_Mutation_p.Q48*	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	174	VWFA 1.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TGGGAGACCTCAGGACTCCGT	0.577													5	39					0	0	0	0	T	98943558	T	T	98943558	4	4	221	1	0	0	0	0	0	1	0	0	9387	827	29	2	526	2	MATN2	8	98943558	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	7003048	98943558	47420464	160	40686											
RGS22	26166	broad.mit.edu	37	chr8	101016160	101016160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttatgtccctcaccttgaaGaatgagtctcaagaaactga	13	11	8	9	0	2	5	2	3	1	2	4	5	3	5	2	0	1	1	2	0	5	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:101016160G>A	uc003yjb.1	-	17	2816	c.2621C>T	c.(2620-2622)TCT>TTT	p.S874F	RGS22_uc003yja.1_Missense_Mutation_p.S693F|RGS22_uc003yjc.1_Missense_Mutation_p.S862F|RGS22_uc011lgz.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	874	RGS 1.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TCACCTTGAAGAATGAGTCTC	0.328													14	29					0	0	0	0	A	101016160	A	A	101016160	3	1	221	1	0	0	0	0	1	0	0	0	13370	942	33	2	1217	2	RGS22	8	101016160	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	2072602	101016160	45347862	161	40687											
AZIN1	51582	broad.mit.edu	37	chr8	103848575	103848575	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaaacttcatgttaccctCttcacctccaatattatctt	10	15	2	14	0	4	0	2	0	2	0	5	0	5	0	4	0	2	1	4	0	5	6	rs142265787		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:103848575C>T	uc003ykx.2	-	7	1235	c.493G>A	c.(493-495)GAG>AAG	p.E165K	AZIN1_uc003yky.2_Missense_Mutation_p.E165K	NM_015878	NP_056962	O14977	AZIN1_HUMAN	ornithine decarboxylase antizyme inhibitor	165					polyamine biosynthetic process|regulation of cellular amino acid metabolic process	cytosol	catalytic activity|protein binding				0	Lung NSC(17;0.000143)|all_lung(17;0.000294)		OV - Ovarian serous cystadenocarcinoma(57;0.000196)|STAD - Stomach adenocarcinoma(118;0.0414)			ATGTTACCCTCTTCACCTCCA	0.413													31	69					0	0	0	0	T	103848575	T	T	103848575	3	4	221	1	0	0	0	0	1	0	0	0	1244	922	32	2	881	2	AZIN1	8	103848575	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2832415	103848575	42515447	162	40688											
TG	7038	broad.mit.edu	37	chr8	133898883	133898883	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttgtggactctgggcttctCcgcccaatggtggagggaca	6	11	14	10	1	2	0	0	0	2	0	3	3	2	3	2	5	0	1	2	5	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:133898883C>G	uc003ytw.2	+	9	1307	c.1266C>G	c.(1264-1266)CTC>CTG	p.L422L		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	422					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTGGGCTTCTCCGCCCAATGG	0.537													8	228					0	0	0	0	G	133898883	G	G	133898883	2	3	221	1	0	0	0	0	0	0	0	1	15879	842	30	2		2	TG	8	133898883	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	30050308	133898883	12465139	163	40689											
EPPK1	83481	broad.mit.edu	37	chr8	144943655	144943655	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgatgctggccttggccccaGagggctgtagcagcacaccg	7	6	14	14	2	0	1	0	0	0	1	0	2	0	1	4	3	3	5	4	3	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:144943655G>A	uc003zaa.1	-	1	3780	c.3767C>T	c.(3766-3768)TCT>TTT	p.S1256F		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1256	Plectin 21.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTTGGCCCCAGAGGGCTGTAG	0.716													10	12					0	0	0	0	A	144943655	A	A	144943655	3	1	221	1	0	0	0	0	1	0	0	0	5214	942	33	2	3499	2	EPPK1	8	144943655	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	11044772	144943655	1420367	164	40690											
PLEC	5339	broad.mit.edu	37	chr8	144990624	144990624	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagccccgtgccctcctcCaccatgctgcggtccagcgc	4	6	10	21	4	0	0	0	0	0	0	3	0	3	0	7	1	5	2	7	1	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr8:144990624C>T	uc003zaf.1	-	32	13946	c.13776G>A	c.(13774-13776)GTG>GTA	p.V4592V	PLEC_uc003zab.1_Silent_p.V4455V|PLEC_uc003zac.1_Silent_p.V4459V|PLEC_uc003zad.2_Silent_p.V4455V|PLEC_uc003zae.1_Silent_p.V4423V|PLEC_uc003zag.1_Silent_p.V4433V|PLEC_uc003zah.2_Silent_p.V4441V|PLEC_uc003zaj.2_Silent_p.V4482V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4592	Globular 2.|Plectin 33.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TGCCCTCCTCCACCATGCTGC	0.647													5	148					0	0	0	0	T	144990624	T	T	144990624	2	4	221	1	0	0	0	0	0	0	0	1	12107	581	21	4		4	PLEC	8	144990624	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	46969	144990624	1373398	165	40691											
IFNA17	3451	broad.mit.edu	37	chr9	21227646	21227646	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgcaagtttgttgaaaaaGagagagatctcatgatttct	13	15	9	4	0	2	4	1	2	2	2	3	6	2	4	0	0	1	3	0	0	3	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:21227646G>C	uc003zos.1	-	1	576	c.527C>G	c.(526-528)TCT>TGT	p.S176C	IFNA14_uc003zoo.1_Intron	NM_021268	NP_067091	P01571	IFN17_HUMAN	interferon, alpha 17 precursor	176					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding				0				Lung(24;2.13e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TGTTGAAAAAGAGAGAGATCT	0.373													78	278					0	0	0	0	C	21227646	C	C	21227646	3	2	221	1	0	0	0	0	1	0	0	0	7575	942	33	2	46	2	IFNA17	9	21227646	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08		21227646	119985785	166	40692											
KIF24	347240	broad.mit.edu	37	chr9	34256601	34256601	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaggtgtggtgactgtgtCtctttggtctggggatccag	5	13	16	7	0	2	2	0	1	2	1	4	3	3	3	1	5	0	0	1	5	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:34256601C>T	uc003zua.3	-	11	3124	c.3004G>A	c.(3004-3006)GAC>AAC	p.D1002N	KIF24_uc010mkb.2_Intron	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	1002					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			GTGACTGTGTCTCTTTGGTCT	0.537													56	81					0	0	0	0	T	34256601	T	T	34256601	3	4	221	1	0	0	0	0	1	0	0	0	8331	913	32	2	1114	2	KIF24	9	34256601	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	13028955	34256601	106956830	167	40693											
SIGMAR1	10280	broad.mit.edu	37	chr9	34635731	34635731	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaagtcctgggtgctgaaGacagtgtcggccagcgcgaa	10	6	16	9	3	0	2	0	1	0	1	2	4	1	3	2	3	2	1	2	3	3	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:34635731G>T	uc003zvb.2	-	4	644	c.570C>A	c.(568-570)GTC>GTA	p.V190V	SIGMAR1_uc003zva.3_Silent_p.V170V|SIGMAR1_uc003zuz.2_Silent_p.V101V|SIGMAR1_uc003zvc.2_Silent_p.V159V|SIGMAR1_uc003zvd.2_RNA|SIGMAR1_uc011loo.1_Intron	NM_005866	NP_005857	Q99720	SGMR1_HUMAN	sigma non-opioid intracellular receptor 1	190	Cytoplasmic (Potential).				ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding				0					Dextromethorphan(DB00514)	GGGTGCTGAAGACAGTGTCGG	0.617													14	55					0.000151284	0.000212474	1	0	T	34635731	T	T	34635731	2	4	221	1	0	0	0	0	0	0	0	1	14381	929	33	2		2	SIGMAR1	9	34635731	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	379130	34635731	106577700	168	40694											
FRMPD1	22844	broad.mit.edu	37	chr9	37740340	37740340	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggctacaggaccagtggctcGagtgagtccatggacgctct	8	8	14	11	2	1	1	0	1	1	0	3	4	2	3	2	4	1	3	2	4	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:37740340G>C	uc004aag.1	+	15	1859	c.1815G>C	c.(1813-1815)TCG>TCC	p.S605S	FRMPD1_uc004aah.1_Silent_p.S605S|FRMPD1_uc011lqm.1_Silent_p.S427S|FRMPD1_uc011lqn.1_Silent_p.S474S	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	605						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CCAGTGGCTCGAGTGAGTCCA	0.637													22	25					0	0	0	0	C	37740340	C	C	37740340	2	2	221	1	0	0	0	0	0	0	0	1	6091	1045	37	3		3	FRMPD1	9	37740340	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	3104609	37740340	103473091	169	40695											
IARS	3376	broad.mit.edu	37	chr9	95036734	95036734	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtaaggagcttggtggaCaacccctgtgccttcttctt	8	12	11	10	0	2	0	0	0	2	0	2	3	2	2	3	3	3	2	3	3	3	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:95036734C>G	uc004art.1	-	10	1221	c.964G>C	c.(964-966)GTC>CTC	p.V322L	IARS_uc004ars.1_Missense_Mutation_p.V167L|IARS_uc004aru.3_Missense_Mutation_p.V322L|IARS_uc010mqr.2_Missense_Mutation_p.V212L|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	322					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	GCTTGGTGGACAACCCCTGTG	0.473													3	129					0	0	0	0	G	95036734	G	G	95036734	3	3	221	1	0	0	0	0	1	0	0	0	7512	478	17	4	2924	4	IARS	9	95036734	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	57296394	95036734	46176697	170	40696											
SMC2	10592	broad.mit.edu	37	chr9	106864358	106864358	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccaaagtacgctcagctgagGaattaaaagaaatgcaagat	18	7	9	7	1	1	3	1	1	0	2	1	4	1	4	1	1	3	4	1	1	7	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:106864358G>C	uc004bbv.2	+	8	1042	c.754G>C	c.(754-756)GAA>CAA	p.E252Q	SMC2_uc004bbu.1_Missense_Mutation_p.E252Q|SMC2_uc004bbw.2_Missense_Mutation_p.E252Q|SMC2_uc011lvl.1_Missense_Mutation_p.E252Q|SMC2_uc010mtg.1_Missense_Mutation_p.E107Q|SMC2_uc010mth.1_Missense_Mutation_p.E202Q|SMC2_uc004bbx.2_Missense_Mutation_p.E252Q	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	252	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						CTCAGCTGAGGAATTAAAAGA	0.313													16	117					0	0	0	0	C	106864358	C	C	106864358	3	2	221	1	0	0	0	0	1	0	0	0	14847	1175	41	2	780	2	SMC2	9	106864358	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	11827624	106864358	34349073	171	40697											
OR13C4	138804	broad.mit.edu	37	chr9	107288808	107288808	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcttcctgtggccgagttcGttcgcaagatggtgtagagg	6	12	15	8	3	1	2	0	0	1	2	4	3	2	2	2	3	0	4	2	3	2	4	rs139144967		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:107288808G>A	uc011lvn.1	-	1	683	c.683C>T	c.(682-684)ACG>ATG	p.T228M		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGCCGAGTTCGTTCGCAAGAT	0.403													66	71					0	0	0	0	A	107288808	A	A	107288808	3	1	221	1	0	0	0	0	1	0	0	0	10990	1145	40	1	275	1	OR13C4	9	107288808	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	424450	107288808	33924623	172	40698											
CTNNAL1	8727	broad.mit.edu	37	chr9	111705270	111705270	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagtttataacaaagtgaaaGaagttggactaagagagcca	18	8	10	5	0	0	3	0	1	0	2	0	5	0	4	1	1	2	2	1	1	6	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:111705270G>C	uc004bdo.1	-	18	2152	c.2110C>G	c.(2110-2112)CTT>GTT	p.L704V	CTNNAL1_uc010mts.1_Missense_Mutation_p.L356V|CTNNAL1_uc010mtt.1_Missense_Mutation_p.L666V|CTNNAL1_uc004bdp.1_Missense_Mutation_p.L704V|CTNNAL1_uc004bdq.1_Missense_Mutation_p.L190V	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	704					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		CAAAGTGAAAGAAGTTGGACT	0.303													19	20					0	0	0	0	C	111705270	C	C	111705270	3	2	221	1	0	0	0	0	1	0	0	0	4032	942	33	2	102	2	CTNNAL1	9	111705270	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4416462	111705270	29508161	173	40699											
GARNL3	84253	broad.mit.edu	37	chr9	130116626	130116626	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgctctgcaaaagggccttGaggggaagcaggctgggaag	10	6	18	7	0	1	1	0	1	1	0	1	3	1	3	1	5	3	4	1	5	4	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:130116626G>C	uc011mae.1	+	19	2097	c.1696G>C	c.(1696-1698)GAG>CAG	p.E566Q	GARNL3_uc011mad.1_Missense_Mutation_p.E544Q|GARNL3_uc010mxi.2_5'Flank	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	566	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AAAGGGCCTTGAGGGGAAGCA	0.443													25	43					0	0	0	0	C	130116626	C	C	130116626	3	2	221	1	0	0	0	0	1	0	0	0	6276	1291	45	2	1770	2	GARNL3	9	130116626	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	18411356	130116626	11096805	174	40700											
PPAPDC3	84814	broad.mit.edu	37	chr9	134165521	134165521	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaaaggcctcgggcccatCagcacagcccccacctgctg	9	4	10	18	1	1	1	1	0	0	1	2	1	1	1	5	2	3	2	5	2	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:134165521C>G	uc004cal.2	+	1	441	c.137C>G	c.(136-138)TCA>TGA	p.S46*		NM_032728	NP_116117	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain	46	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(1)	1	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)		TCGGGCCCATCAGCACAGCCC	0.682													9	23					0	0	0	0	G	134165521	G	G	134165521	4	3	221	1	0	0	0	0	0	1	0	0	12351	838	29	2	139	2	PPAPDC3	9	134165521	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	4048895	134165521	7047910	175	40701											
GBGT1	26301	broad.mit.edu	37	chr9	136031310	136031310	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgctccagcagcttgggctGagggtactgtgacctgcaac	7	9	14	11	0	0	2	0	2	0	0	1	2	1	2	2	2	6	6	2	2	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:136031310G>A	uc004ccw.2	-	5	483	c.202C>T	c.(202-204)CAG>TAG	p.Q68*	RALGDS_uc011mcw.1_Missense_Mutation_p.S80L|GBGT1_uc004ccx.2_Nonsense_Mutation_p.Q21*|GBGT1_uc010nab.2_Nonsense_Mutation_p.Q68*|GBGT1_uc011mcx.1_Nonsense_Mutation_p.Q51*|GBGT1_uc010nac.1_5'UTR|GBGT1_uc004ccy.1_Nonsense_Mutation_p.Q68*	NM_021996	NP_068836	Q8N5D6	GBGT1_HUMAN	globoside	68	Lumenal (Potential).				carbohydrate metabolic process|glycolipid biosynthetic process	Golgi membrane|integral to membrane	metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;3.49e-06)|Epithelial(140;2.59e-05)		AGCTTGGGCTGAGGGTACTGT	0.557													53	61					0	0	0	0	A	136031310	A	A	136031310	4	1	221	1	0	0	0	0	0	1	0	0	6307	1299	45	2	853	2	GBGT1	9	136031310	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1865789	136031310	5182121	176	40702											
NOTCH1	4851	broad.mit.edu	37	chr9	139401042	139401042	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggcgcaggtgcccccattCttgcagggcttgcctttgca	5	10	12	14	2	1	0	0	0	1	0	1	0	1	0	3	3	4	4	3	3	0	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:139401042C>G	uc004chz.2	-	24	3951	c.3951G>C	c.(3949-3951)AAG>AAC	p.K1317N	NOTCH1_uc004cia.1_Missense_Mutation_p.K547N	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1317	Extracellular (Potential).|EGF-like 34.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		TGCCCCCATTCTTGCAGGGCT	0.687			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			3	17					0	0	0	0	G	139401042	G	G	139401042	3	3	221	1	0	0	0	0	1	0	0	0	10601	912	32	2	3760	2	NOTCH1	9	139401042	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	3369732	139401042	1812389	177	40703											
NDOR1	27158	broad.mit.edu	37	chr9	140109353	140109353	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgccgctccttcttcgaactCctggcctgtctatccctcca	4	12	6	19	3	2	0	0	0	2	0	7	1	6	0	6	1	1	1	6	1	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:140109353C>T	uc004clw.2	+	8	1059	c.948C>T	c.(946-948)CTC>CTT	p.L316L	NDOR1_uc004clx.2_Silent_p.L316L|NDOR1_uc011mes.1_Silent_p.L316L|NDOR1_uc004cly.2_Silent_p.L282L	NM_014434	NP_055249	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	316	FAD-binding FR-type.				cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TCTTCGAACTCCTGGCCTGTC	0.637													67	47					0	0	0	0	T	140109353	T	T	140109353	2	4	221	1	0	0	0	0	0	0	0	1	10303	842	30	2		2	NDOR1	9	140109353	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	708311	140109353	1104078	178	40704											
EHMT1	79813	broad.mit.edu	37	chr9	140728824	140728824	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggaggtttactgcatcgaCgcgcggttctacgggaacgt	7	9	16	9	6	1	0	0	0	1	0	2	3	1	2	0	5	4	3	0	5	3	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr9:140728824C>T	uc011mfc.1	+	26	3601	c.3564C>T	c.(3562-3564)GAC>GAT	p.D1188D	EHMT1_uc004coe.2_Silent_p.D93D	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1188	SET.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		ACTGCATCGACGCGCGGTTCT	0.672													12	37					0	0	0	0	T	140728824	T	T	140728824	2	4	221	1	0	0	0	0	0	0	0	1	5005	535	19	1		1	EHMT1	9	140728824	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	619471	140728824	484607	179	40705											
GTPBP4	23560	broad.mit.edu	37	chr10	1045024	1045024	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcacatggattataagtatCtacgttggcaggtgagagtc	11	11	13	6	1	1	1	0	1	1	1	2	3	1	2	0	4	1	4	0	4	4	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:1045024C>G	uc001ift.2	+	6	714	c.643C>G	c.(643-645)CTA>GTA	p.L215V	GTPBP4_uc010qac.1_Missense_Mutation_p.L6V|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Missense_Mutation_p.L99V|GTPBP4_uc010qae.1_Missense_Mutation_p.L168V	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	215					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		TTATAAGTATCTACGTTGGCA	0.303													13	28					0	0	0	0	G	1045024	G	G	1045024	3	3	221	1	0	0	0	0	1	0	0	0	6921	912	32	2	665	2	GTPBP4	10	1045024	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08		1045024	134489723	180	40706											
CUBN	8029	broad.mit.edu	37	chr10	16957859	16957859	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatctccacgaagtctttttCacagccagaagaattctgaa	13	11	7	10	1	4	3	1	1	3	2	5	5	4	3	2	0	1	0	2	0	4	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:16957859C>G	uc001ioo.2	-	46	7223	c.7171G>C	c.(7171-7173)GAA>CAA	p.E2391Q		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2391	CUB 17.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAGTCTTTTTCACAGCCAGAA	0.413													18	39					0	0	0	0	G	16957859	G	G	16957859	3	3	221	1	0	0	0	0	1	0	0	0	4068	835	29	2	3788	2	CUBN	10	16957859	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	15912835	16957859	118576888	181	40707											
KIAA1217	56243	broad.mit.edu	37	chr10	24669819	24669819	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaggagccccaaactgtctCacagtcctcaaccacccagt	12	6	6	17	0	2	0	2	0	1	0	4	1	3	1	5	1	3	0	5	1	3	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:24669819C>T	uc001iru.3	+	3	779	c.376C>T	c.(376-378)CAC>TAC	p.H126Y	KIAA1217_uc001irs.2_Missense_Mutation_p.H46Y|KIAA1217_uc001irt.3_Missense_Mutation_p.H126Y|KIAA1217_uc010qcy.1_Missense_Mutation_p.H126Y|KIAA1217_uc010qcz.1_Missense_Mutation_p.H126Y|KIAA1217_uc001irv.1_5'UTR|KIAA1217_uc010qda.1_RNA	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	126					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CAAACTGTCTCACAGTCCTCA	0.468													17	45					0	0	0	0	T	24669819	T	T	24669819	3	4	221	1	0	0	0	0	1	0	0	0	8255	826	29	2	386	2	KIAA1217	10	24669819	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	7711960	24669819	110864928	182	40708											
BAMBI	25805	broad.mit.edu	37	chr10	28971090	28971090	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcttcgaagtgaaaataaGaggctgcaggatcagcggca	14	7	13	7	2	1	2	1	1	0	1	2	4	1	3	0	3	3	4	0	3	4	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:28971090G>C	uc001iuj.1	+	3	946	c.543G>C	c.(541-543)AAG>AAC	p.K181N	BAMBI_uc001iui.2_3'UTR	NM_012342	NP_036474	Q13145	BAMBI_HUMAN	BMP and activin membrane-bound inhibitor	181	Cytoplasmic (Potential).				cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of protein binding|positive regulation of transcription, DNA-dependent|regulation of cell shape	cytoplasm|integral to membrane|plasma membrane	frizzled binding|type II transforming growth factor beta receptor binding			central_nervous_system(4)	4						GTGAAAATAAGAGGCTGCAGG	0.507													18	46					0	0	0	0	C	28971090	C	C	28971090	3	2	221	1	0	0	0	0	1	0	0	0	1308	933	33	2	553	2	BAMBI	10	28971090	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4301271	28971090	106563657	183	40709											
PCDH15	65217	broad.mit.edu	37	chr10	55582664	55582664	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattccagtgttttcattttCagctttctgcctggtgcctt	4	19	8	10	0	3	0	2	0	1	0	4	1	4	0	3	1	3	2	3	1	0	7			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:55582664C>T	uc001jju.1	-	33	5217	c.4822G>A	c.(4822-4824)GAA>AAA	p.E1608K	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.E1605K|PCDH15_uc010qhw.1_Missense_Mutation_p.E1568K|PCDH15_uc010qhx.1_Missense_Mutation_p.E1539K|PCDH15_uc010qhy.1_Missense_Mutation_p.E1615K|PCDH15_uc010qhz.1_Missense_Mutation_p.E1610K|PCDH15_uc010qia.1_Missense_Mutation_p.E1588K|PCDH15_uc010qib.1_Missense_Mutation_p.E1585K	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1608	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTTTCATTTTCAGCTTTCTGC	0.443										HNSCC(58;0.16)			75	85					0	0	0	0	T	55582664	T	T	55582664	3	4	221	1	0	0	0	0	1	0	0	0	11565	835	29	2	2655	2	PCDH15	10	55582664	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	26611574	55582664	79952083	184	40710											
PHYHIPL	84457	broad.mit.edu	37	chr10	60936718	60936718	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcagctgtgcgaccgggaCggtaagagcggccgggaccg	8	5	17	11	6	1	1	1	0	0	1	1	4	1	3	3	4	3	2	3	4	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:60936718C>T	uc001jkk.3	+	1	371	c.105C>T	c.(103-105)GAC>GAT	p.D35D	PHYHIPL_uc001jkl.3_Translation_Start_Site|PHYHIPL_uc001jkm.3_5'Flank	NM_032439	NP_115815	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting	35											0						GCGACCGGGACGGTAAGAGCG	0.697													6	18					0	0	0	0	T	60936718	T	T	60936718	2	4	221	1	0	0	0	0	0	0	0	1	11922	550	19	1		1	PHYHIPL	10	60936718	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	5354054	60936718	74598029	185	40711											
DDX21	9188	broad.mit.edu	37	chr10	70737400	70737400	+	Frame_Shift_Del	DEL	G	-	-																															cagcactggcccatatttcaGgtgccacgtccgtagaccag																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:70737400delG	uc001jov.1	+	12	1948	c.1858delG	c.(1858-1860)GGTfs	p.G620fs	DDX21_uc001jow.1_Frame_Shift_Del_p.G552fs	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	620						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						CCATATTTCAGGTGCCACGTC	0.502													---	---	---								-	70737400	-	-	70737400	7	5	221	1	0	1	0	1	0	0	0	0	4366	1000	35	0	1904	0	DDX21	10	70737400	Frame_Shift_Del	DEL	G	TCGA-CV-7099-01A-41D-2012-08	9800682	70737400	64797347	186	40712											
ZNF503	84858	broad.mit.edu	37	chr10	77158680	77158680	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcgcgtggtgggggctgcGcagcgccagcgtcccagggc	4	4	19	14	5	0	0	0	0	0	0	1	0	1	0	2	4	4	2	2	4	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:77158680G>C	uc001jxg.2	-	2	2104	c.1768C>G	c.(1768-1770)CGC>GGC	p.R590G	C10orf41_uc010qlf.1_5'Flank	NM_032772	NP_116161	Q96F45	ZN503_HUMAN	zinc finger protein 503	590					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1	all_cancers(46;0.105)|all_epithelial(25;0.00449)|Prostate(51;0.0112)|Ovarian(15;0.088)					TGGGGGCTGCGCAGCGCCAGC	0.751													5	9					0	0	0	0	C	77158680	C	C	77158680	3	2	221	1	0	0	0	0	1	0	0	0	18018	1087	38	3	176	3	ZNF503	10	77158680	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	6421280	77158680	58376067	187	40713											
WAPAL	23063	broad.mit.edu	37	chr10	88277758	88277758	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagtccgtttgttggaaaaGacttcatcgaattttgaact	11	15	9	6	2	1	2	1	1	0	1	3	4	2	3	1	1	1	3	1	1	5	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:88277758G>C	uc001kdo.2	-	2	511	c.69C>G	c.(67-69)GTC>GTG	p.V23V	WAPAL_uc001kdn.2_Silent_p.V66V|WAPAL_uc009xsw.2_Silent_p.V23V|WAPAL_uc010qmh.1_Silent_p.V23V|WAPAL_uc010qmi.1_Silent_p.V60V|WAPAL_uc010qmj.1_Silent_p.V23V	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	23	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						TGTTGGAAAAGACTTCATCGA	0.398													4	49					0	0	0	0	C	88277758	C	C	88277758	2	2	221	1	0	0	0	0	0	0	0	1	17316	929	33	2		2	WAPAL	10	88277758	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	11119078	88277758	47256989	188	40714											
LCOR	84458	broad.mit.edu	37	chr10	98714869	98714869	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagattagtgaagaactactGagcagaaaccaattgtccac	16	8	8	9	0	0	5	0	2	0	3	1	5	1	5	2	0	4	1	2	0	6	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:98714869G>A	uc001kms.1	+	8	1013	c.492G>A	c.(490-492)CTG>CTA	p.L164L	LCOR_uc001kmr.2_Silent_p.L164L|C10orf12_uc009xvg.1_Intron|LCOR_uc001kmt.1_Silent_p.L164L|LCOR_uc001kmu.1_Silent_p.L164L	NM_032440	NP_115816	Q96JN0	LCOR_HUMAN	ligand dependent nuclear receptor corepressor	164						nucleus	DNA binding			ovary(3)	3		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		AAGAACTACTGAGCAGAAACC	0.478													21	31					0	0	0	0	A	98714869	A	A	98714869	2	1	221	1	0	0	0	0	0	0	0	1	8729	1277	45	2		2	LCOR	10	98714869	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	10437111	98714869	36819878	189	40715											
KNDC1	85442	broad.mit.edu	37	chr10	135015069	135015069	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctcacccacctcggtgtcGgatgtggactcggacgcact	6	9	12	14	4	1	0	1	0	0	0	4	3	1	3	2	4	1	2	2	4	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:135015069G>A	uc001llz.1	+	17	3055	c.3054G>A	c.(3052-3054)TCG>TCA	p.S1018S	KNDC1_uc001lma.1_Silent_p.S953S|KNDC1_uc001lmb.1_Silent_p.S430S	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1018					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CCTCGGTGTCGGATGTGGACT	0.617													36	68					0	0	0	0	A	135015069	A	A	135015069	2	1	221	1	0	0	0	0	0	0	0	1	8465	1103	39	1		1	KNDC1	10	135015069	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	36300200	135015069	519678	190	40716											
KNDC1	85442	broad.mit.edu	37	chr10	135015189	135015189	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggacagacggccagctggCggggcctcagacgtggaggc	8	3	19	11	3	1	2	1	0	0	2	1	5	1	4	2	7	1	1	2	7	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr10:135015189C>T	uc001llz.1	+	17	3175	c.3174C>T	c.(3172-3174)GGC>GGT	p.G1058G	KNDC1_uc001lma.1_Silent_p.G993G|KNDC1_uc001lmb.1_Silent_p.G470G	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1058					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GGCCAGCTGGCGGGGCCTCAG	0.682													11	34					0	0	0	0	T	135015189	T	T	135015189	2	4	221	1	0	0	0	0	0	0	0	1	8465	755	27	1		1	KNDC1	10	135015189	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	120	135015189	519558	191	40717											
EPS8L2	64787	broad.mit.edu	37	chr11	721618	721618	+	Silent	SNP	G	A	A																															tggtttgtggcccggctgcaGaaggcagccgaggctttcaa																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:721618G>A	uc001lqt.2	+	10	1069	c.822G>A	c.(820-822)CAG>CAA	p.Q274Q	EPS8L2_uc010qwj.1_Silent_p.Q290Q|EPS8L2_uc001lqu.2_Silent_p.Q274Q|EPS8L2_uc010qwk.1_Silent_p.Q290Q|EPS8L2_uc001lqv.2_Silent_p.Q229Q|EPS8L2_uc001lqw.2_5'UTR|EPS8L2_uc001lqx.2_5'Flank|EPS8L2_uc001lqy.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	274						cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCCGGCTGCAGAAGGCAGCCG	0.557													29	54					0	0	0	0	A	721618	A	A	721618	2	1	221	1	0	0	0	0	0	0	0	1	5220	933	33	2		2	EPS8L2	11	721618	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08		721618	134284898	192	40718	84	2									
EPS8L2	64787	broad.mit.edu	37	chr11	721628	721628	+	Missense_Mutation	SNP	G	A	A																															cccggctgcagaaggcagccGaggctttcaagcagctgaac																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:721628G>A	uc001lqt.2	+	10	1079	c.832G>A	c.(832-834)GAG>AAG	p.E278K	EPS8L2_uc010qwj.1_Missense_Mutation_p.E294K|EPS8L2_uc001lqu.2_Missense_Mutation_p.E278K|EPS8L2_uc010qwk.1_Missense_Mutation_p.E294K|EPS8L2_uc001lqv.2_Missense_Mutation_p.E233K|EPS8L2_uc001lqw.2_5'UTR|EPS8L2_uc001lqx.2_5'Flank|EPS8L2_uc001lqy.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	278						cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAAGGCAGCCGAGGCTTTCAA	0.517													27	50					0	0	0	0	A	721628	A	A	721628	3	1	221	1	0	0	0	0	1	0	0	0	5220	1059	37	1	866	1	EPS8L2	11	721628	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	10	721628	134284888	193	40719	84	2									
NUP98	4928	broad.mit.edu	37	chr11	3740767	3740767	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcacatctccttcaaaataGattgaaccataacctataaa	17	12	2	10	0	3	2	2	1	1	1	4	2	3	2	3	0	2	0	3	0	8	7			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:3740767G>C	uc001lyh.2	-	18	2565	c.2274C>G	c.(2272-2274)ATC>ATG	p.I758M	NUP98_uc001lyi.2_Missense_Mutation_p.I758M|NUP98_uc001lyj.1_Missense_Mutation_p.I758M|NUP98_uc001lyk.1_Missense_Mutation_p.I775M	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	775	Peptidase S59.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CTTCAAAATAGATTGAACCAT	0.308			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								9	23					0	0	0	0	C	3740767	C	C	3740767	3	2	221	1	0	0	0	0	1	0	0	0	10827	932	33	2	3213	2	NUP98	11	3740767	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	3019139	3740767	131265749	194	40720											
SYT9	143425	broad.mit.edu	37	chr11	7334938	7334938	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcttcctgatcggaaaacAaaacaccagactaaagttca	16	9	6	10	1	1	2	1	1	0	1	3	3	2	3	2	1	3	2	2	1	6	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:7334938A>G	uc001mfe.2	+	3	1047	c.810A>G	c.(808-810)ACA>ACG	p.T270T	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	270	Cytoplasmic (Potential).|C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		ATCGGAAAACAAAACACCAGA	0.423													9	184					0	0	0	0	G	7334938	G	G	7334938	2	3	221	1	0	0	0	0	0	0	0	1	15547	117	5	5		5	SYT9	11	7334938	Silent	SNP	A	TCGA-CV-7099-01A-41D-2012-08	3594171	7334938	127671578	195	40721											
ST5	6764	broad.mit.edu	37	chr11	8724164	8724164	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccggcgctccagcagcagtGaggcaaagattcggatgagc	10	5	14	12	3	0	3	0	2	0	1	2	4	1	4	2	3	3	4	2	3	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:8724164G>C	uc001mgt.2	-	14	2861	c.2675C>G	c.(2674-2676)TCA>TGA	p.S892*	ST5_uc009yfr.2_Nonsense_Mutation_p.S472*|ST5_uc001mgu.2_Nonsense_Mutation_p.S472*|ST5_uc001mgv.2_Nonsense_Mutation_p.S892*|ST5_uc010rbp.1_Nonsense_Mutation_p.S405*|ST5_uc009yfs.2_RNA	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	892	DENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CAGCAGCAGTGAGGCAAAGAT	0.592													16	55					0	0	0	0	C	8724164	C	C	8724164	4	2	221	1	0	0	0	0	0	1	0	0	15286	1294	45	2	766	2	ST5	11	8724164	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1389226	8724164	126282352	196	40722											
ARNTL	406	broad.mit.edu	37	chr11	13397291	13397291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagtagaatatattgtctCaactaacactgttgttttgt	12	16	8	5	0	1	1	1	0	1	1	2	2	1	2	0	1	2	3	0	1	7	8			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:13397291C>T	uc001mkr.2	+	15	1715	c.1307C>T	c.(1306-1308)TCA>TTA	p.S436L	ARNTL_uc001mko.2_Missense_Mutation_p.S392L|ARNTL_uc001mkp.2_Missense_Mutation_p.S435L|ARNTL_uc001mkq.2_Missense_Mutation_p.S435L|ARNTL_uc001mks.2_Missense_Mutation_p.S393L|ARNTL_uc001mkt.2_Missense_Mutation_p.S436L|ARNTL_uc001mku.2_RNA|ARNTL_uc009ygm.1_Missense_Mutation_p.S275L|ARNTL_uc001mkw.2_Missense_Mutation_p.S393L|ARNTL_uc001mkx.2_Missense_Mutation_p.S434L|ARNTL_uc001mky.2_5'UTR	NM_001178	NP_001169	O00327	BMAL1_HUMAN	aryl hydrocarbon receptor nuclear	436	PAC.				circadian rhythm|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	aryl hydrocarbon receptor binding|DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity				0				Epithelial(150;0.0243)		TATATTGTCTCAACTAACACT	0.403													12	21					0	0	0	0	T	13397291	T	T	13397291	3	4	221	1	0	0	0	0	1	0	0	0	969	838	29	2	1361	2	ARNTL	11	13397291	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	4673127	13397291	121609225	197	40723											
MYBPC3	4607	broad.mit.edu	37	chr11	47353698	47353698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagacatagatgcccccgtCaaaggggcagggctttctaa	11	7	12	11	1	2	2	1	0	1	2	2	2	2	2	2	3	1	3	2	3	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:47353698C>T	uc001nfa.3	-	32	3794	c.3739G>A	c.(3739-3741)GAC>AAC	p.D1247N		NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	1246	Ig-like C2-type 7.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		ATGCCCCCGTCAAAGGGGCAG	0.627													28	48					0	0	0	0	T	47353698	T	T	47353698	3	4	221	1	0	0	0	0	1	0	0	0	10066	826	29	2	93	2	MYBPC3	11	47353698	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	33956407	47353698	87652818	198	40724											
OR4S2	219431	broad.mit.edu	37	chr11	55418944	55418944	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgaaacttgcctgcacaGaaacatacattgttggtgtt	11	14	9	7	0	0	2	0	1	0	1	0	2	0	2	1	1	5	4	1	1	3	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:55418944G>T	uc001nhs.1	+	1	565	c.565G>T	c.(565-567)GAA>TAA	p.E189*		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				TGCCTGCACAGAAACATACAT	0.438													35	170					9.17885e-22	1.34941e-21	1	0	T	55418944	T	T	55418944	4	4	221	1	0	0	0	0	0	1	0	0	11137	943	33	2	567	2	OR4S2	11	55418944	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	8065246	55418944	79587572	199	40725											
SMTNL1	219537	broad.mit.edu	37	chr11	57310335	57310335	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggggaagcaaatggattaGatgaggtcaaagtggaatct	15	8	15	3	0	2	2	1	1	1	1	2	5	2	5	0	5	1	1	0	5	5	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:57310335G>C	uc009ymh.1	+	2	274	c.274G>C	c.(274-276)GAT>CAT	p.D92H		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	74										ovary(1)	1						AAATGGATTAGATGAGGTCAA	0.542													3	8					0	0	0	0	C	57310335	C	C	57310335	3	2	221	1	0	0	0	0	1	0	0	0	14879	942	33	2	280	2	SMTNL1	11	57310335	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1891391	57310335	77696181	200	40726											
OSBP	5007	broad.mit.edu	37	chr11	59377944	59377944	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttctgaactagctttcaGatggtaggtctgagcacccc	10	11	9	11	0	3	3	1	2	2	1	3	3	3	3	2	2	4	3	2	2	4	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:59377944G>A	uc001noc.1	-	2	961	c.481C>T	c.(481-483)CTG>TTG	p.L161L		NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	161	PH.				lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CTAGCTTTCAGATGGTAGGTC	0.557													28	75					0	0	0	0	A	59377944	A	A	59377944	2	1	221	1	0	0	0	0	0	0	0	1	11327	933	33	2		2	OSBP	11	59377944	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	2067609	59377944	75628572	201	40727											
CABP4	57010	broad.mit.edu	37	chr11	67223246	67223246	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catacgggcccctgctcaatCgagtcttcgggaaggttagg	8	9	13	11	3	2	0	1	0	1	0	4	2	2	1	2	4	2	2	2	4	4	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:67223246C>T	uc001olo.2	+	1	429	c.352C>T	c.(352-354)CGA>TGA	p.R118*	CABP4_uc001oln.2_5'UTR	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	118					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CCTGCTCAATCGAGTCTTCGG	0.662													6	11					0	0	0	0	T	67223246	T	T	67223246	4	4	221	1	0	0	0	0	0	1	0	0	2545	876	31	1	354	1	CABP4	11	67223246	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	7845302	67223246	67783270	202	40728											
MTL5	9633	broad.mit.edu	37	chr11	68514686	68514686	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcataattaccattgggttgGaatctttcttaagagaacag	13	13	9	6	0	2	1	0	0	2	1	2	3	2	2	1	2	2	2	1	2	5	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:68514686G>T	uc001ooc.2	-	3	760	c.620C>A	c.(619-621)TCC>TAC	p.S207Y	MTL5_uc001ood.1_Missense_Mutation_p.S207Y|MTL5_uc009ysi.1_Missense_Mutation_p.S207Y|MTL5_uc001ooe.2_Missense_Mutation_p.S207Y	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	207					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			CATTGGGTTGGAATCTTTCTT	0.418													11	31					1.61879e-10	2.33734e-10	1	0	T	68514686	T	T	68514686	3	4	221	1	0	0	0	0	1	0	0	0	9989	1174	41	2	942	2	MTL5	11	68514686	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1291440	68514686	66491830	203	40729											
GDPD5	81544	broad.mit.edu	37	chr11	75148046	75148046	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggcgcaccgcagcactcAgcatgatctgctcagggttg	7	8	12	14	3	3	1	2	1	1	0	4	1	4	1	2	2	3	6	2	2	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:75148046A>G	uc001owo.3	-	17	2141	c.1604T>C	c.(1603-1605)CTG>CCG	p.L535P	GDPD5_uc001owp.3_Missense_Mutation_p.L535P|GDPD5_uc001own.3_Missense_Mutation_p.L290P|GDPD5_uc009yuc.2_Missense_Mutation_p.L397P|GDPD5_uc009yud.2_Missense_Mutation_p.L416P	NM_030792	NP_110419	Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain	535	Cytoplasmic (Potential).				glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			ovary(1)	1						CGCAGCACTCAGCATGATCTG	0.622													13	33					0	0	0	0	G	75148046	G	G	75148046	3	3	221	1	0	0	0	0	1	0	0	0	6364	188	7	5	221	5	GDPD5	11	75148046	Missense_Mutation	SNP	A	TCGA-CV-7099-01A-41D-2012-08	6633360	75148046	59858470	204	40730											
SERPINH1	871	broad.mit.edu	37	chr11	75277820	75277820	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggacccagctcagtgagcttCgctgatgacttcgtgcgcag	7	9	13	12	3	1	3	1	3	0	0	3	4	1	4	1	1	3	4	1	1	0	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:75277820C>T	uc001owr.2	+	2	655	c.426C>T	c.(424-426)TTC>TTT	p.F142F	SERPINH1_uc009yuf.2_Silent_p.F142F|SERPINH1_uc009yug.2_Silent_p.F142F|SERPINH1_uc001ows.2_Silent_p.F142F|SERPINH1_uc001owt.2_5'Flank	NM_001235	NP_001226	P50454	SERPH_HUMAN	serine (or cysteine) proteinase inhibitor, clade	142					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			ovary(2)	2	Ovarian(111;0.11)					CAGTGAGCTTCGCTGATGACT	0.627													8	38					0	0	0	0	T	75277820	T	T	75277820	2	4	221	1	0	0	0	0	0	0	0	1	14182	883	31	1		1	SERPINH1	11	75277820	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	129774	75277820	59728696	205	40731											
THRSP	7069	broad.mit.edu	37	chr11	77775068	77775068	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagctgagtgggcctgggggCcaggcccaggctgaggcccc	5	4	18	14	0	0	2	0	2	0	0	0	2	0	2	5	6	1	2	5	6	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:77775068C>G	uc001oyx.2	+	1	162	c.141C>G	c.(139-141)GGC>GGG	p.G47G		NM_003251	NP_003242	Q92748	THRSP_HUMAN	thyroid hormone-responsive protein	47					lipid biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus				breast(1)	1	all_cancers(14;2.23e-19)|all_epithelial(13;7.49e-22)|Breast(9;6.38e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;2.15e-25)			GGCCTGGGGGCCAGGCCCAGG	0.637													19	105					0	0	0	0	G	77775068	G	G	77775068	2	3	221	1	0	0	0	0	0	0	0	1	15942	726	26	4		4	THRSP	11	77775068	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2497248	77775068	57231448	206	40732											
DSCAML1	57453	broad.mit.edu	37	chr11	117308639	117308639	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggtcttggcctcgatgatCtcgctgatgcgcccagagcc	5	10	13	13	3	2	3	0	2	2	1	4	4	2	3	3	2	2	1	3	2	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr11:117308639C>G	uc001prh.1	-	25	4586	c.4584G>C	c.(4582-4584)GAG>GAC	p.E1528D		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1468	Fibronectin type-III 5.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCTCGATGATCTCGCTGATGC	0.662													3	27					0	0	0	0	G	117308639	G	G	117308639	3	3	221	1	0	0	0	0	1	0	0	0	4791	912	32	2	1793	2	DSCAML1	11	117308639	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	39533571	117308639	17697877	207	40733											
CHD4	1108	broad.mit.edu	37	chr12	6709458	6709459	+	Missense_Mutation	DNP	GG	TA	TA																															cagaccatgtggtaagcacgGggacaggtatcacacaggat																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:6709458_6709459GG>TA	uc001qpo.2	-	9	1330_1331	c.1166_1167CC>TA	c.(1165-1167)CCC>CTA	p.P389L	CHD4_uc001qpn.2_Missense_Mutation_p.P382L|CHD4_uc001qpp.2_Missense_Mutation_p.P386L	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	389	PHD-type 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GGTAAGCACGGGGACAGGTATC	0.594													15	99					0	0	0	0	TA	6709459	TA	TA	6709458	3	4	221	1	0	0	0	0	1	0	0	0	3342	1219	43	4	4699	4	CHD4	12	6709458	Missense_Mutation	DNP	GG	TCGA-CV-7099-01A-41D-2012-08		6709458	127142437	208	40734											
PTPN6	5777	broad.mit.edu	37	chr12	7069304	7069304	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccagatggtgcgggcgcagCgctcgggcatggtgcagacg	6	6	18	11	5	0	2	0	0	0	2	2	2	1	2	1	4	3	4	1	4	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:7069304C>T	uc001qsb.2	+	13	1725	c.1483C>T	c.(1483-1485)CGC>TGC	p.R495C	PTPN6_uc001qsa.1_Missense_Mutation_p.R497C|PTPN6_uc010sfr.1_Missense_Mutation_p.R456C|PTPN6_uc009zfl.1_Missense_Mutation_p.R495C|PTPN6_uc010sfs.1_Missense_Mutation_p.R483C	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	495	Tyrosine-protein phosphatase.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						GCGGGCGCAGCGCTCGGGCAT	0.592													10	42					0	0	0	0	T	7069304	T	T	7069304	3	4	221	1	0	0	0	0	1	0	0	0	12857	768	27	1	1551	1	PTPN6	12	7069304	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	359846	7069304	126782591	209	40735											
TAS2R14	50840	broad.mit.edu	37	chr12	11091369	11091369	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttatatggatgtttatcagTgcaatatttaaaaacaagaa	17	15	6	3	0	1	1	1	0	0	1	1	2	1	2	0	1	2	2	0	1	10	8			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:11091369T>C	uc010shi.1	-	1	438	c.438A>G	c.(436-438)GCA>GCG	p.A146A	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_023922	NP_076411	Q9NYV8	T2R14_HUMAN	taste receptor, type 2, member 14	146	Helical; Name=4; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste		bitter taste receptor activity				0						TGTTTATCAGTGCAATATTTA	0.343													16	37					0	0	0	0	C	11091369	C	C	11091369	2	2	221	1	0	0	0	0	0	0	0	1	15634	1683	59	5		5	TAS2R14	12	11091369	Silent	SNP	T	TCGA-CV-7099-01A-41D-2012-08	4022065	11091369	122760526	210	40736											
SLC4A8	9498	broad.mit.edu	37	chr12	51868959	51868959	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctcaagcaccttaaagaCgtttaagacgagccgttatt	12	11	7	11	3	1	2	1	0	1	2	2	3	1	2	3	0	2	3	3	0	5	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:51868959C>T	uc001rys.1	+	16	2319	c.2141C>T	c.(2140-2142)ACG>ATG	p.T714M	SLC4A8_uc001rym.2_Missense_Mutation_p.T661M|SLC4A8_uc001ryn.2_Missense_Mutation_p.T661M|SLC4A8_uc001ryo.2_Missense_Mutation_p.T661M|SLC4A8_uc010snj.1_Missense_Mutation_p.T741M|SLC4A8_uc001ryr.2_Missense_Mutation_p.T714M|SLC4A8_uc010snk.1_Missense_Mutation_p.T661M	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	714	Cytoplasmic (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		ACCTTAAAGACGTTTAAGACG	0.443													5	80					0	0	0	0	T	51868959	T	T	51868959	3	4	221	1	0	0	0	0	1	0	0	0	14723	536	19	1	2203	1	SLC4A8	12	51868959	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	40777590	51868959	81982936	211	40737											
KRT6A	3853	broad.mit.edu	37	chr12	52882219	52882220	+	Frame_Shift_Ins	INS	-	T	T																															tcagcagccgggccaggtccINStgcttggccttctgcagggc																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:52882219_52882220insT	uc001sam.2	-	7	1525_1526	c.1316_1317insA	c.(1315-1317)CAGfs	p.Q439fs		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	439	Rod.|Coil 2.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		GGGCCAGGTCCTGCTTGGCCTT	0.624													---	---	---								T	52882220	T	T	52882219	7	5	221	1	0	1	1	0	0	0	0	0	8519	680	24	0	389	0	KRT6A	12	52882219	Frame_Shift_Ins	INS	-	TCGA-CV-7099-01A-41D-2012-08	1013260	52882219	80969676	212	40738											
KRT1	3848	broad.mit.edu	37	chr12	53071509	53071509	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgaaggtccaccttggtCatataagcaccatccacatc	11	9	7	14	0	1	1	1	1	0	0	4	1	3	1	5	2	1	1	5	2	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:53071509C>A	uc001sau.1	-	4	947	c.888G>T	c.(886-888)ATG>ATT	p.M296I	KRT1_uc001sav.1_Missense_Mutation_p.M296I	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	296	Coil 1B.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						CCACCTTGGTCATATAAGCAC	0.478													25	60					7.92952e-12	1.15376e-11	1	0	A	53071509	A	A	53071509	3	1	221	1	0	0	0	0	1	0	0	0	8486	826	29	2	1070	2	KRT1	12	53071509	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	189290	53071509	80780386	213	40739											
ERBB3	2065	broad.mit.edu	37	chr12	56477581	56477581	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgtgaccggcgatgctgaGaaccaataccagacactgta	13	7	11	10	2	0	3	0	2	0	2	0	5	0	3	3	1	3	2	3	1	4	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:56477581G>A	uc001sjh.2	+	2	322	c.129G>A	c.(127-129)GAG>GAA	p.E43E	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_5'UTR|ERBB3_uc001sjg.2_Silent_p.E43E	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	43	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GCGATGCTGAGAACCAATACC	0.547													51	138					0	0	0	0	A	56477581	A	A	56477581	2	1	221	1	0	0	0	0	0	0	0	1	5232	933	33	2		2	ERBB3	12	56477581	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	3406072	56477581	77374314	214	40740											
ERBB3	2065	broad.mit.edu	37	chr12	56481620	56481620	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcagtgtaatggtcactgcTttgggcccaaccccaaccag	9	9	9	14	0	2	0	2	0	0	0	2	0	2	0	4	2	3	2	4	2	3	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:56481620T>C	uc001sjh.2	+	6	848	c.655T>C	c.(655-657)TTT>CTT	p.F219L	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.F160L|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	219	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TGGTCACTGCTTTGGGCCCAA	0.547													26	89					0	0	0	0	C	56481620	C	C	56481620	3	2	221	1	0	0	0	0	1	0	0	0	5232	1609	56	5	808	5	ERBB3	12	56481620	Missense_Mutation	SNP	T	TCGA-CV-7099-01A-41D-2012-08	4039	56481620	77370275	215	40741											
CAND1	55832	broad.mit.edu	37	chr12	67706416	67706416	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcagtaaagcaggagtttGaaaaacaagatgaattaaag	20	8	9	4	0	1	3	1	2	0	1	1	4	1	4	0	1	2	3	0	1	8	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:67706416G>C	uc001stn.2	+	15	3936	c.3499G>C	c.(3499-3501)GAA>CAA	p.E1167Q	CAND1_uc001sto.2_Missense_Mutation_p.E677Q	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	1167	HEAT 27.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		GCAGGAGTTTGAAAAACAAGA	0.393													9	18					0	0	0	0	C	67706416	C	C	67706416	3	2	221	1	0	0	0	0	1	0	0	0	2627	1291	45	2	3557	2	CAND1	12	67706416	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	11224796	67706416	66145479	216	40742											
LRRIQ1	84125	broad.mit.edu	37	chr12	85434273	85434273	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattcaaatttttaggattcAgttgaattaccagaatcagt	14	16	6	5	0	3	2	3	1	0	1	3	3	3	3	1	1	1	1	1	1	6	8			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:85434273A>G	uc001tac.2	+	3	249	c.138A>G	c.(136-138)TCA>TCG	p.S46S	LRRIQ1_uc001tab.1_Silent_p.S46S|LRRIQ1_uc001taa.1_Silent_p.S46S|LRRIQ1_uc001tad.2_5'UTR	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	46										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TTTAGGATTCAGTTGAATTAC	0.328													22	53					0	0	0	0	G	85434273	G	G	85434273	2	3	221	1	0	0	0	0	0	0	0	1	9079	175	7	5		5	LRRIQ1	12	85434273	Silent	SNP	A	TCGA-CV-7099-01A-41D-2012-08	17727857	85434273	48417622	217	40743											
STAB2	55576	broad.mit.edu	37	chr12	104063327	104063327	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtttttcagattccaaaGtgctgcaaaggcttctatgg	9	16	9	7	0	2	1	1	0	1	1	3	1	3	1	1	2	2	4	1	2	3	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:104063327G>A	uc001tjw.2	+	21	2367	c.2181G>A	c.(2179-2181)AAG>AAA	p.K727K		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	727	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AGATTCCAAAGTGCTGCAAAG	0.438													4	79					0	0	0	0	A	104063327	A	A	104063327	2	1	221	1	0	0	0	0	0	0	0	1	15304	1020	36	4		4	STAB2	12	104063327	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	18629054	104063327	29788568	218	40744											
HCFC2	29915	broad.mit.edu	37	chr12	104461751	104461751	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgttggttatggaaaaaagtGaaaccccatccccctccttc	11	10	7	13	1	0	1	0	1	0	0	3	2	2	2	5	2	1	2	5	2	5	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:104461751G>C	uc001tkj.3	+	3	442	c.339G>C	c.(337-339)GTG>GTC	p.V113V	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	113	Kelch 2.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						GGAAAAAAGTGAAACCCCATC	0.408													53	119					0	0	0	0	C	104461751	C	C	104461751	2	2	221	1	0	0	0	0	0	0	0	1	7032	1277	45	2		2	HCFC2	12	104461751	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	398424	104461751	29390144	219	40745											
ACAD10	80724	broad.mit.edu	37	chr12	112183993	112183993	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaccttttcctacccttaGaggctgatcccgagaaaaaa	13	9	8	11	1	0	3	0	1	0	2	2	5	2	4	4	2	2	1	4	2	6	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:112183993G>C	uc001tsq.2	+	14	2361	c.2161G>C	c.(2161-2163)GAG>CAG	p.E721Q	ACAD10_uc001tsp.2_Missense_Mutation_p.E721Q|ACAD10_uc009zvx.2_Missense_Mutation_p.E752Q|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	721							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						CCTACCCTTAGAGGCTGATCC	0.468													21	44					0	0	0	0	C	112183993	C	C	112183993	3	2	221	1	0	0	0	0	1	0	0	0	108	943	33	2	2308	2	ACAD10	12	112183993	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	7722242	112183993	21667902	220	40746											
KNTC1	9735	broad.mit.edu	37	chr12	123102942	123102942	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatacagataccactgctttCaggtatttcgctctctgaaa	11	13	7	10	1	2	2	1	1	1	1	4	3	2	2	1	1	3	3	1	1	4	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:123102942C>G	uc001ucv.2	+	58	6246	c.6083C>G	c.(6082-6084)TCA>TGA	p.S2028*	KNTC1_uc010taf.1_Nonsense_Mutation_p.S953*	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	2028					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CCACTGCTTTCAGGTATTTCG	0.393													11	24					0	0	0	0	G	123102942	G	G	123102942	4	3	221	1	0	0	0	0	0	1	0	0	8467	838	29	2	6309	2	KNTC1	12	123102942	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	10918949	123102942	10748953	221	40747											
GPR81	27198	broad.mit.edu	37	chr12	123214171	123214171	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccagaggaaatagagtctaGcagacacgctgggcaggtag	13	6	14	8	1	1	3	0	0	1	3	2	4	2	4	1	3	1	4	1	3	4	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:123214171G>A	uc001ucz.2	-	1	959	c.716C>T	c.(715-717)GCT>GTT	p.A239V	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	239	Helical; Name=6; (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		ATAGAGTCTAGCAGACACGCT	0.572													23	45					0	0	0	0	A	123214171	A	A	123214171	3	1	221	1	0	0	0	0	1	0	0	0	6749	971	34	4	328	4	GPR81	12	123214171	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	111229	123214171	10637724	222	40748											
DDX55	57696	broad.mit.edu	37	chr12	124092179	124092179	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gatcggaggcaggaatcctgGagaagatgttgagaggttta	12	9	16	4	1	0	3	0	1	0	3	2	8	1	5	1	5	0	3	1	5	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr12:124092179G>A	uc001ufi.2	+	5	395	c.371G>A	c.(370-372)GGA>GAA	p.G124E	DDX55_uc001ufh.2_5'UTR|DDX55_uc001ufj.1_Intron|DDX55_uc001ufk.2_5'UTR	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	124	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		AGGAATCCTGGAGAAGATGTT	0.443													42	129					0	0	0	0	A	124092179	A	A	124092179	3	1	221	1	0	0	0	0	1	0	0	0	4390	1174	41	2	389	2	DDX55	12	124092179	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	878008	124092179	9759716	223	40749											
IFT88	8100	broad.mit.edu	37	chr13	21172820	21172820	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atttggccagtcagtattcaGttaatgaaatgtatgccgaa	13	13	9	6	1	2	1	2	1	0	0	2	2	2	1	2	1	1	3	2	1	5	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr13:21172820G>T	uc001unh.2	+	12	1048	c.652G>T	c.(652-654)GTT>TTT	p.V218F	IFT88_uc001uni.2_Missense_Mutation_p.V209F|IFT88_uc001unj.2_Missense_Mutation_p.V208F|IFT88_uc010tcq.1_Missense_Mutation_p.V189F|IFT88_uc001unk.2_5'UTR	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	218	TPR 1.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TCAGTATTCAGTTAATGAAAT	0.323													9	81					2.80697e-09	4.04261e-09	1	0	T	21172820	T	T	21172820	3	4	221	1	0	0	0	0	1	0	0	0	7605	1029	36	4	690	4	IFT88	13	21172820	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08		21172820	93997058	224	40750											
SLC7A1	6541	broad.mit.edu	37	chr13	30091803	30091803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttttcaaagagaacatctCtgcctctggtaaaaagccca	13	10	8	10	0	3	1	1	0	2	1	4	2	3	1	2	2	3	2	2	2	5	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr13:30091803C>T	uc001uso.2	-	10	1804	c.1417G>A	c.(1417-1419)GAG>AAG	p.E473K		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	473	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GAGAACATCTCTGCCTCTGGT	0.453													10	88					0	0	0	0	T	30091803	T	T	30091803	3	4	221	1	0	0	0	0	1	0	0	0	14756	922	32	2	488	2	SLC7A1	13	30091803	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	8918983	30091803	85078075	225	40751											
SERPINE3	647174	broad.mit.edu	37	chr13	51922447	51922447	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgctgccccgtgacaaaGacacccccctgagccacatc	9	6	9	17	1	0	3	0	2	0	1	1	3	0	3	6	1	3	1	6	1	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr13:51922447G>C	uc001vfh.2	+	4	859	c.799G>C	c.(799-801)GAC>CAC	p.D267H	SERPINE3_uc010tgp.1_Missense_Mutation_p.D267H	NM_001101320	NP_001094790	A8MV23	SERP3_HUMAN	nexin-related serine protease inhibitor	267					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)	2						CCGTGACAAAGACACCCCCCT	0.612													16	22					0	0	0	0	C	51922447	C	C	51922447	3	2	221	1	0	0	0	0	1	0	0	0	14178	942	33	2	813	2	SERPINE3	13	51922447	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	21830644	51922447	63247431	226	40752											
MYCBP2	23077	broad.mit.edu	37	chr13	77667369	77667369	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttgcatcaggagttactGatatatacggggcaggtaca	12	10	12	7	1	1	1	1	1	0	0	1	3	1	2	0	4	4	4	0	4	5	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr13:77667369G>A	uc001vkf.2	-	60	10275	c.10184C>T	c.(10183-10185)TCA>TTA	p.S3395L	MYCBP2_uc010aev.2_Missense_Mutation_p.S2799L|MYCBP2_uc001vke.2_Missense_Mutation_p.S15L	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGGAGTTACTGATATATACGG	0.393													5	80					0	0	0	0	A	77667369	A	A	77667369	3	1	221	1	0	0	0	0	1	0	0	0	10071	1294	45	2	3838	2	MYCBP2	13	77667369	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	25744922	77667369	37502509	227	40753											
KDELC1	79070	broad.mit.edu	37	chr13	103450951	103450951	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccgggctcagctgcctttCtccgccggtctcggcgagtg	2	10	13	16	5	3	0	1	0	2	0	6	1	4	0	4	3	2	2	4	3	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr13:103450951C>G	uc001vpq.3	-	1	454	c.70G>C	c.(70-72)GAA>CAA	p.E24Q	KDELC1_uc001vpr.3_5'UTR|BIVM_uc001vps.2_5'Flank|BIVM_uc010agc.2_5'Flank	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	24	Filamin.					endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AGCTGCCTTTCTCCGCCGGTC	0.532													20	28					0	0	0	0	G	103450951	G	G	103450951	3	3	221	1	0	0	0	0	1	0	0	0	8156	922	32	2	1478	2	KDELC1	13	103450951	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	25783582	103450951	11718927	228	40754											
C13orf16	121793	broad.mit.edu	37	chr13	111996452	111996452	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagggacaataacagaagcCgaagaaactgaggactgact	18	4	11	8	1	0	4	0	2	0	2	0	7	0	6	1	2	3	0	1	2	5	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr13:111996452C>T	uc001vsa.2	+	6	567	c.438C>T	c.(436-438)GCC>GCT	p.A146A		NM_152324	NP_689537	Q8N6K0	CM016_HUMAN	hypothetical protein LOC121793	146	Cytoplasmic (Potential).					integral to membrane					0	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		all cancers(43;0.113)|GBM - Glioblastoma multiforme(44;0.174)|BRCA - Breast invasive adenocarcinoma(86;0.188)			TAACAGAAGCCGAAGAAACTG	0.383													17	27					0	0	0	0	T	111996452	T	T	111996452	2	4	221	1	0	0	0	0	0	0	0	1	1725	639	23	1		1	C13orf16	13	111996452	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	8545501	111996452	3173426	229	40755											
SOX1	6656	broad.mit.edu	37	chr13	112722212	112722212	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaagatgcacaactcggaGatcagcaagcgcctgggggc	11	4	13	13	2	1	2	1	0	0	2	2	3	1	2	2	3	4	2	2	3	3	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr13:112722212G>A	uc001vsb.1	+	1	300	c.240G>A	c.(238-240)GAG>GAA	p.E80E		NM_005986	NP_005977	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	80	HMG box.				chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		ACAACTCGGAGATCAGCAAGC	0.657													22	23					0	0	0	0	A	112722212	A	A	112722212	2	1	221	1	0	0	0	0	0	0	0	1	15004	933	33	2		2	SOX1	13	112722212	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	725760	112722212	2447666	230	40756											
JUB	84962	broad.mit.edu	37	chr14	23444286	23444286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatcggaaacagcctggatGataggacttccccattgctt	10	10	10	11	1	0	1	0	1	0	0	2	4	1	4	3	3	3	2	3	3	2	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr14:23444286G>A	uc001whz.2	-	5	1643	c.1267C>T	c.(1267-1269)CAT>TAT	p.H423Y	JUB_uc001why.2_Missense_Mutation_p.H6Y	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	423	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CAGCCTGGATGATAGGACTTC	0.512													21	52					0	0	0	0	A	23444286	A	A	23444286	3	1	221	1	0	0	0	0	1	0	0	0	8007	1290	45	2	365	2	JUB	14	23444286	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08		23444286	83905254	231	40757											
CDH24	64403	broad.mit.edu	37	chr14	23518917	23518917	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctactgttgccaacttcatCtctgtccagggcccggatga	7	11	10	13	1	2	1	1	1	1	0	4	2	3	2	3	2	3	2	3	2	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr14:23518917C>G	uc001wil.2	-	11	1890	c.1630G>C	c.(1630-1632)GAT>CAT	p.D544H	CDH24_uc001wik.3_RNA|CDH24_uc010akf.2_Missense_Mutation_p.D506H	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	544	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CCAACTTCATCTCTGTCCAGG	0.582													8	16					0	0	0	0	G	23518917	G	G	23518917	3	3	221	1	0	0	0	0	1	0	0	0	3124	913	32	2	841	2	CDH24	14	23518917	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	74631	23518917	83830623	232	40758											
PRKD1	5587	broad.mit.edu	37	chr14	30046490	30046490	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctttcatttctgtttctTcagtctcaggagtgtcactg	5	17	10	9	0	6	0	4	0	3	0	7	1	6	1	0	2	0	2	0	2	0	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr14:30046490T>A	uc001wqh.2	-	18	2874	c.2693A>T	c.(2692-2694)GAA>GTA	p.E898V		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	898					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TTCTGTTTCTTCAGTCTCAGG	0.493													13	79					0	0	0	0	A	30046490	A	A	30046490	3	1	221	1	0	0	0	0	1	0	0	0	12580	1783	62	5	49	5	PRKD1	14	30046490	Missense_Mutation	SNP	T	TCGA-CV-7099-01A-41D-2012-08	6527573	30046490	77303050	233	40759											
HEATR5A	25938	broad.mit.edu	37	chr14	31813139	31813139	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctagacaagttgacatgtCgtggagcaaacatatgaagc	14	8	12	7	1	0	3	0	2	0	1	1	4	0	4	0	2	3	3	0	2	5	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr14:31813139C>T	uc001wrf.3	-	15	2389	c.2312G>A	c.(2311-2313)CGA>CAA	p.R771Q	HEATR5A_uc010ami.2_Missense_Mutation_p.R669Q|HEATR5A_uc001wrg.1_Missense_Mutation_p.R653Q|HEATR5A_uc010tpk.1_Missense_Mutation_p.R1064Q	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1058							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		GTTGACATGTCGTGGAGCAAA	0.428													16	46					0	0	0	0	T	31813139	T	T	31813139	3	4	221	1	0	0	0	0	1	0	0	0	7070	884	31	1	3013	1	HEATR5A	14	31813139	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1766649	31813139	75536401	234	40760											
ATP6V1D	51382	broad.mit.edu	37	chr14	67815782	67815782	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatctttcttcgctcgaatCttcacttgcgctttattgac	6	19	5	11	3	4	1	1	1	3	0	6	2	4	1	0	0	1	2	0	0	3	8			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr14:67815782C>G	uc001xjf.2	-	4	455	c.279G>C	c.(277-279)AAG>AAC	p.K93N	ATP6V1D_uc001xje.2_RNA	NM_015994	NP_057078	Q9Y5K8	VATD_HUMAN	H(+)-transporting two-sector ATPase	93					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain|vacuolar proton-transporting V-type ATPase complex	protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)|lung(1)	2				all cancers(60;0.000739)|OV - Ovarian serous cystadenocarcinoma(108;0.00597)|BRCA - Breast invasive adenocarcinoma(234;0.00957)		TCGCTCGAATCTTCACTTGCG	0.368													13	26					0	0	0	0	G	67815782	G	G	67815782	3	3	221	1	0	0	0	0	1	0	0	0	1184	912	32	2	488	2	ATP6V1D	14	67815782	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	36002643	67815782	39533758	235	40761											
PLEKHH1	57475	broad.mit.edu	37	chr14	68022580	68022580	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggctgctggaggcagagcaGagagcagagaacgctgagac	13	3	17	8	1	0	4	0	1	0	4	0	8	0	5	0	3	4	6	0	3	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr14:68022580G>C	uc001xjl.1	+	3	307	c.165G>C	c.(163-165)CAG>CAC	p.Q55H		NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	55	Potential.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		AGGCAGAGCAGAGAGCAGAGA	0.607													4	23					0	0	0	0	C	68022580	C	C	68022580	3	2	221	1	0	0	0	0	1	0	0	0	12131	933	33	2	171	2	PLEKHH1	14	68022580	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	206798	68022580	39326960	236	40762											
ATXN3	4287	broad.mit.edu	37	chr14	92549555	92549555	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcatctgcaggagttggtCagcttcgcaatctggcagat	10	11	11	9	1	4	1	2	0	2	1	5	2	4	2	0	3	2	5	0	3	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr14:92549555C>T	uc001yac.3	-	7	592	c.523G>A	c.(523-525)GAC>AAC	p.D175N	ATXN3_uc010aug.2_Missense_Mutation_p.D160N|ATXN3_uc001yad.3_Missense_Mutation_p.D120N|ATXN3_uc010auh.2_Missense_Mutation_p.D109N|ATXN3_uc001yae.3_Missense_Mutation_p.D77N|ATXN3_uc010twl.1_RNA	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	175	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		AGGAGTTGGTCAGCTTCGCAA	0.373													42	61					0	0	0	0	T	92549555	T	T	92549555	3	4	221	1	0	0	0	0	1	0	0	0	1215	826	29	2	582	2	ATXN3	14	92549555	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	24526975	92549555	14799985	237	40763											
LGMN	5641	broad.mit.edu	37	chr14	93199105	93199105	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaatgcccagggccacactGaggaatacagctactttcca	12	7	8	14	0	0	1	0	1	0	0	1	2	1	2	4	2	4	1	4	2	4	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr14:93199105G>A	uc001yav.2	-	3	353	c.27C>T	c.(25-27)CTC>CTT	p.L9L	LGMN_uc001yat.2_Silent_p.L9L|LGMN_uc001yau.2_Silent_p.L9L|LGMN_uc001yaw.2_Silent_p.L9L|LGMN_uc010aul.2_5'UTR|LGMN_uc001yax.2_Silent_p.L9L|LGMN_uc001yay.2_Silent_p.L9L	NM_001008530	NP_001008530	Q99538	LGMN_HUMAN	legumain preproprotein	9					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			skin(1)	1		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		GGGCCACACTGAGGAATACAG	0.478													22	65					0	0	0	0	A	93199105	A	A	93199105	2	1	221	1	0	0	0	0	0	0	0	1	8796	1277	45	2		2	LGMN	14	93199105	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	649550	93199105	14150435	238	40764											
KIAA1409	57578	broad.mit.edu	37	chr14	94083611	94083611	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccctaaagcctcacatccgGcagatgtggttgaaggcctt	9	10	10	12	1	1	2	1	1	0	1	3	2	3	2	4	3	1	2	4	3	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr14:94083611G>A	uc001ybv.1	+	26	3803	c.3720G>A	c.(3718-3720)CGG>CGA	p.R1240R	KIAA1409_uc001ybs.1_Silent_p.R1218R	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1395						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CTCACATCCGGCAGATGTGGT	0.498													8	92					0	0	0	0	A	94083611	A	A	94083611	2	1	221	1	0	0	0	0	0	0	0	1	8269	1190	42	4		4	KIAA1409	14	94083611	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	884506	94083611	13265929	239	40765											
MAGEL2	54551	broad.mit.edu	37	chr15	23890608	23890608	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctcgcgcagctgacactGccttgggagcacagaaggtg	8	7	15	11	2	0	2	0	1	0	1	1	3	0	3	1	2	4	4	1	2	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr15:23890608G>T	uc001ywj.3	-	1	568	c.473C>A	c.(472-474)GCA>GAA	p.A158E		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		AGCTGACACTGCCTTGGGAGC	0.612													4	40					0.00024832	0.000347894	1	0	T	23890608	T	T	23890608	3	4	221	1	0	0	0	0	1	0	0	0	9242	1319	46	4	1471	4	MAGEL2	15	23890608	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08		23890608	78640784	240	40766											
DISP2	85455	broad.mit.edu	37	chr15	40662125	40662125	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagccccagcccactctcCtaaggccaaggctgcagatc	11	5	9	16	0	1	2	0	0	1	2	3	2	1	2	5	2	3	2	5	2	3	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr15:40662125C>T	uc001zlk.1	+	8	3901	c.3812C>T	c.(3811-3813)CCT>CTT	p.P1271L		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	1271					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		GCCCACTCTCCTAAGGCCAAG	0.647													15	42					0	0	0	0	T	40662125	T	T	40662125	3	4	221	1	0	0	0	0	1	0	0	0	4562	681	24	4	3842	4	DISP2	15	40662125	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	16771517	40662125	61869267	241	40767											
LTK	4058	broad.mit.edu	37	chr15	41804949	41804949	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgccacagctgcacgcctctCagctgcccggcggcccccac	5	4	10	22	4	1	0	1	0	1	0	2	0	1	0	5	2	4	3	5	2	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr15:41804949C>T	uc001zoa.3	-	3	493	c.315G>A	c.(313-315)CTG>CTA	p.L105L	LTK_uc001zob.3_Silent_p.L105L|LTK_uc010ucx.1_Silent_p.L105L|LTK_uc010bcg.2_Intron	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	105	Extracellular (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		GCACGCCTCTCAGCTGCCCGG	0.697										TSP Lung(18;0.14)			7	15					0	0	0	0	T	41804949	T	T	41804949	2	4	221	1	0	0	0	0	0	0	0	1	9130	813	29	2		2	LTK	15	41804949	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1142824	41804949	60726443	242	40768											
B2M	567	broad.mit.edu	37	chr15	45007631	45007632	+	Frame_Shift_Ins	INS	-	A	A																															attcctcaggtactccaaagINSattcaggtttactcacgtca																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr15:45007631_45007632insA	uc001zuc.2	+	2	138_139	c.78_79insA	c.(76-81)AAGATTfs	p.K26fs	B2M_uc010uek.1_Frame_Shift_Ins_p.K26fs|B2M_uc010bdx.1_Frame_Shift_Ins_p.K26fs	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	26_27	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GTACTCCAAAGATTCAGGTTTA	0.421													---	---	---								A	45007632	A	A	45007631	7	5	221	1	0	1	1	0	0	0	0	0	1246	933	33	0	84	0	B2M	15	45007631	Frame_Shift_Ins	INS	-	TCGA-CV-7099-01A-41D-2012-08	3202682	45007631	57523761	243	40769											
ANKDD1A	348094	broad.mit.edu	37	chr15	65219178	65219178	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctcgtgggctctggctgtGaccacaatgtcaaagacaag	10	9	11	11	1	2	2	1	1	1	1	4	2	3	2	2	2	0	2	2	2	3	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr15:65219178G>C	uc002aoa.2	+	6	579	c.550G>C	c.(550-552)GAC>CAC	p.D184H	ANKDD1A_uc002anx.1_Missense_Mutation_p.D180H|ANKDD1A_uc002any.2_Missense_Mutation_p.D93H|ANKDD1A_uc002anz.2_Missense_Mutation_p.D93H|ANKDD1A_uc002aob.2_Intron|ANKDD1A_uc002aoc.2_RNA|ANKDD1A_uc010bha.2_Missense_Mutation_p.D93H	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	184	ANK 5.				signal transduction					ovary(1)	1						CTCTGGCTGTGACCACAATGT	0.617													4	81					0	0	0	0	C	65219178	C	C	65219178	3	2	221	1	0	0	0	0	1	0	0	0	624	1290	45	2	572	2	ANKDD1A	15	65219178	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	20211547	65219178	37312214	244	40770											
MTFMT	123263	broad.mit.edu	37	chr15	65319319	65319319	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcactggcagtccttttggtGatggggaaggcattgtgacc	7	12	14	8	0	1	2	1	2	0	0	2	3	2	3	2	5	0	2	2	5	1	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr15:65319319G>C	uc002aof.3	-	2	295	c.269C>G	c.(268-270)TCA>TGA	p.S90*		NM_139242	NP_640335	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	90						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			ovary(2)	2					Tetrahydrofolic acid(DB00116)	TCCTTTTGGTGATGGGGAAGG	0.443													12	43					0	0	0	0	C	65319319	C	C	65319319	4	2	221	1	0	0	0	0	0	1	0	0	9977	1294	45	2	932	2	MTFMT	15	65319319	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	100141	65319319	37212073	245	40771											
GOLGA6A	342096	broad.mit.edu	37	chr15	74372982	74372982	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caggtgagtggcaaccaccgGaagtggttgtctcagggcta	9	8	15	9	1	1	1	1	1	1	0	2	2	1	2	2	5	1	3	2	5	3	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr15:74372982G>C	uc002axa.1	-	2	220	c.179C>G	c.(178-180)TCC>TGC	p.S60C		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	60	Potential.										0						GCAACCACCGGAAGTGGTTGT	0.463													18	136					0	0	0	0	C	74372982	C	C	74372982	3	2	221	1	0	0	0	0	1	0	0	0	6594	1174	41	2	1970	2	GOLGA6A	15	74372982	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	9053663	74372982	28158410	246	40772											
WDR90	197335	broad.mit.edu	37	chr16	712044	712044	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcttcttgtcctgggaggcgGatgacggtggcattggtgag	5	11	18	7	2	1	2	0	2	1	0	2	4	2	4	1	6	0	2	1	6	0	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:712044G>A	uc002cii.1	+	32	4072	c.4018G>A	c.(4018-4020)GAT>AAT	p.D1340N	WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Missense_Mutation_p.D867N|WDR90_uc002cil.1_RNA|WDR90_uc002cim.1_Missense_Mutation_p.D514N|WDR90_uc002cin.1_5'UTR|WDR90_uc010uul.1_5'Flank|WDR90_uc002cio.1_5'Flank|WDR90_uc010bqx.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1340	WD 16.									ovary(1)	1		Hepatocellular(780;0.0218)				CTGGGAGGCGGATGACGGTGG	0.652													10	30					0	0	0	0	A	712044	A	A	712044	3	1	221	1	0	0	0	0	1	0	0	0	17405	1174	41	2	4144	2	WDR90	16	712044	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08		712044	89642709	247	40773											
C1QTNF8	390664	broad.mit.edu	37	chr16	1143809	1143809	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggaagcggcccgcggccaGgtcgaaggcgccgtccaggt	7	3	18	13	6	0	0	0	0	0	0	2	3	1	1	4	6	1	0	4	6	2	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:1143809G>A	uc010uuw.1	-	4	725	c.451C>T	c.(451-453)CTG>TTG	p.L151L		NM_207419	NP_997302	P60827	C1QT8_HUMAN	C1q and tumor necrosis factor related protein 8	151	C1q.					collagen				skin(1)	1		Hepatocellular(780;0.00369)				CCCGCGGCCAGGTCGAAGGCG	0.667													4	48					0	0	0	0	A	1143809	A	A	1143809	2	1	221	1	0	0	0	0	0	0	0	1	1978	991	35	4		4	C1QTNF8	16	1143809	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	431765	1143809	89210944	248	40774											
CASKIN1	57524	broad.mit.edu	37	chr16	2234836	2234836	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctccccatagacctgcccgGcgtgggccactggaggctgg	5	6	15	15	2	0	1	0	0	0	1	1	2	1	2	5	5	1	2	5	5	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:2234836G>A	uc010bsg.1	-	14	1390	c.1358C>T	c.(1357-1359)GCC>GTC	p.A453V		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	453	CASK-binding (By similarity).				signal transduction	cytoplasm				skin(2)	2						GACCTGCCCGGCGTGGGCCAC	0.687													7	29					0	0	0	0	A	2234836	A	A	2234836	3	1	221	1	0	0	0	0	1	0	0	0	2678	1203	42	4	2965	4	CASKIN1	16	2234836	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1091027	2234836	88119917	249	40775											
BTBD12	84464	broad.mit.edu	37	chr16	3639184	3639184	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttctcttgcaatttcctCtgggtagtgcagcttcctcg	5	15	9	12	1	2	0	0	0	2	0	6	1	4	0	2	1	3	4	2	1	2	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:3639184C>T	uc002cvp.2	-	12	5082	c.4455G>A	c.(4453-4455)CAG>CAA	p.Q1485Q		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1485	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						GCAATTTCCTCTGGGTAGTGC	0.647								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				69	139					0	0	0	0	T	3639184	T	T	3639184	2	4	221	1	0	0	0	0	0	0	0	1	1545	912	32	2		2	BTBD12	16	3639184	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1404348	3639184	86715569	250	40776											
UBN1	29855	broad.mit.edu	37	chr16	4924969	4924969	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gacagcggccaaaggccaggGcttccatccctctgcaccag	9	5	11	16	1	1	0	0	0	1	0	3	1	3	0	5	3	2	2	5	3	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:4924969G>A	uc002cyb.2	+	15	2897	c.2558G>A	c.(2557-2559)GGC>GAC	p.G853D	UBN1_uc010uxw.1_Missense_Mutation_p.G853D|UBN1_uc002cyc.2_Missense_Mutation_p.G853D	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	853					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						AAAGGCCAGGGCTTCCATCCC	0.592													5	84					0	0	0	0	A	4924969	A	A	4924969	3	1	221	1	0	0	0	0	1	0	0	0	16960	1203	42	4	2612	4	UBN1	16	4924969	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1285785	4924969	85429784	251	40777											
ERCC4	2072	broad.mit.edu	37	chr16	14015908	14015908	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtattttatcaatcagctGaagatagaaggagttgaaca	16	11	10	4	0	2	4	2	2	0	2	2	6	2	5	0	1	2	3	0	1	7	5	rs61760162		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:14015908G>A	uc002dce.2	+	2	237	c.228G>A	c.(226-228)CTG>CTA	p.L76L	ERCC4_uc010bva.2_Silent_p.L76L	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	76					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						TCAATCAGCTGAAGATAGAAG	0.353			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				5	17					0	0	0	0	A	14015908	A	A	14015908	2	1	221	1	0	0	0	0	0	0	0	1	5239	1277	45	2		2	ERCC4	16	14015908	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	9090939	14015908	76338845	252	40778											
C16orf45	89927	broad.mit.edu	37	chr16	15661909	15661909	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgcagaacttggtcgccatCccaggtaaccatttgcaact	10	10	8	13	1	0	1	0	0	0	1	2	1	1	1	3	2	5	3	3	2	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:15661909C>T	uc002ddo.2	+	3	486	c.300C>T	c.(298-300)ATC>ATT	p.I100I	C16orf45_uc002ddp.2_Silent_p.I83I	NM_033201	NP_149978	Q96MC5	CP045_HUMAN	hypothetical protein LOC89927 isoform 1	100										ovary(1)	1						TGGTCGCCATCCCAGGTAACC	0.552													6	14					0	0	0	0	T	15661909	T	T	15661909	2	4	221	1	0	0	0	0	0	0	0	1	1820	845	30	2		2	C16orf45	16	15661909	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1646001	15661909	74692844	253	40779											
CD19	930	broad.mit.edu	37	chr16	28944612	28944612	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtggggtaccccctgactCtgtgtccaggggccccctct	3	10	12	16	0	2	1	0	1	2	0	3	1	3	1	5	4	1	1	5	4	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:28944612C>G	uc002drs.2	+	4	679	c.617C>G	c.(616-618)TCT>TGT	p.S206C	uc010vct.1_Intron|CD19_uc010byo.1_Missense_Mutation_p.S206C	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	206	Extracellular (Potential).|Ig-like C2-type 2.				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						CCCCCTGACTCTGTGTCCAGG	0.612													14	25					0	0	0	0	G	28944612	G	G	28944612	3	3	221	1	0	0	0	0	1	0	0	0	2988	913	32	2	631	2	CD19	16	28944612	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	13282703	28944612	61410141	254	40780											
ZNF646	9726	broad.mit.edu	37	chr16	31092645	31092645	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggaggacaagcggtgacgtCcatggcggctgaggacaagg	10	4	19	8	3	0	2	0	2	0	0	1	5	1	5	1	7	1	1	1	7	2	0	rs80281572	byFrequency	TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:31092645C>T	uc002eap.2	+	2	5289	c.5000C>T	c.(4999-5001)TCC>TTC	p.S1667F		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1667					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						GCGGTGACGTCCATGGCGGCT	0.662													11	50					0	0	0	0	T	31092645	T	T	31092645	3	4	221	1	0	0	0	0	1	0	0	0	18129	855	30	2	5002	2	ZNF646	16	31092645	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2148033	31092645	59262108	255	40781											
NLRC5	84166	broad.mit.edu	37	chr16	57060491	57060491	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatgttaccctccattccCgctgggtacagcggaccaaa	10	9	9	13	2	0	0	0	0	0	0	2	1	2	1	4	2	3	4	4	2	4	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:57060491C>T	uc002ekk.1	+	6	1861	c.1636C>T	c.(1636-1638)CGC>TGC	p.R546C	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.R351C|NLRC5_uc002ekl.2_Missense_Mutation_p.R351C|NLRC5_uc002ekm.2_Missense_Mutation_p.R351C|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	546					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CCTCCATTCCCGCTGGGTACA	0.612													74	84					0	0	0	0	T	57060491	T	T	57060491	3	4	221	1	0	0	0	0	1	0	0	0	10524	652	23	1	1650	1	NLRC5	16	57060491	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	25967846	57060491	33294262	256	40782											
COG4	25839	broad.mit.edu	37	chr16	70515274	70515274	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacctacccgctccagattGaggatggtggccatctggga	8	8	12	13	1	1	2	0	1	1	1	2	4	2	4	5	4	1	1	5	4	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:70515274G>C	uc002ezc.2	-	18	2234	c.2223C>G	c.(2221-2223)CTC>CTG	p.L741L	COG4_uc002eza.2_Silent_p.L78L|COG4_uc002ezb.2_Silent_p.L197L|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Silent_p.L720L|COG4_uc002eze.2_Silent_p.L435L	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	737	D domain.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				GCTCCAGATTGAGGATGGTGG	0.592													6	166					0	0	0	0	C	70515274	C	C	70515274	2	2	221	1	0	0	0	0	0	0	0	1	3675	1277	45	2		2	COG4	16	70515274	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	13454783	70515274	19839479	257	40783											
ZFHX3	463	broad.mit.edu	37	chr16	72992559	72992559	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttcctcatccaactcgcttgGaaagagtcctttgcaaccct	9	12	6	14	1	1	1	1	0	0	1	5	2	4	2	4	1	3	2	4	1	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:72992559G>A	uc002fck.2	-	2	2159	c.1486C>T	c.(1486-1488)CCA>TCA	p.P496S	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	496					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				AACTCGCTTGGAAAGAGTCCT	0.323													32	48					0	0	0	0	A	72992559	A	A	72992559	3	1	221	1	0	0	0	0	1	0	0	0	17701	1174	41	2	9661	2	ZFHX3	16	72992559	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	2477285	72992559	17362194	258	40784											
KARS	3735	broad.mit.edu	37	chr16	75665700	75665700	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcaaatcaatcccctcattCcggaactggcgtccaatttc	10	11	6	14	2	3	0	3	0	0	0	7	1	6	1	4	2	1	0	4	2	4	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:75665700C>T	uc002feq.2	-	8	1017	c.969G>A	c.(967-969)CGG>CGA	p.R323R	KARS_uc002fer.2_Silent_p.R351R|KARS_uc002fes.2_Silent_p.R167R	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	323	ATP.				interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	TCCCCTCATTCCGGAACTGGC	0.463													72	100					0	0	0	0	T	75665700	T	T	75665700	2	4	221	1	0	0	0	0	0	0	0	1	8019	842	30	2		2	KARS	16	75665700	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2673141	75665700	14689053	259	40785											
PLCG2	5336	broad.mit.edu	37	chr16	81968079	81968079	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaaccagtccatcgccatcGagctctctgacctggttgtc	8	10	9	14	2	1	2	0	1	1	1	6	3	2	2	4	1	2	2	4	1	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr16:81968079G>A	uc002fgt.2	+	26	2937	c.2785G>A	c.(2785-2787)GAG>AAG	p.E929K		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	929					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						CATCGCCATCGAGCTCTCTGA	0.478													18	30					0	0	0	0	A	81968079	A	A	81968079	3	1	221	1	0	0	0	0	1	0	0	0	12091	1059	37	1	2883	1	PLCG2	16	81968079	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	6302379	81968079	8386674	260	40786											
PRPF8	10594	broad.mit.edu	37	chr17	1582167	1582167	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcattcccaaaacgagatttCtttctttcctggagaagatg	11	13	8	9	1	2	3	0	0	2	3	4	5	4	3	2	1	1	1	2	1	3	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:1582167C>G	uc002fte.2	-	12	1722	c.1608G>C	c.(1606-1608)AAG>AAC	p.K536N		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	536						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		AACGAGATTTCTTTCTTTCCT	0.468													6	43					0	0	0	0	G	1582167	G	G	1582167	3	3	221	1	0	0	0	0	1	0	0	0	12637	912	32	2	5527	2	PRPF8	17	1582167	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08		1582167	79613043	261	40787											
PRPF8	10594	broad.mit.edu	37	chr17	1582626	1582626	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccgatgcttcagggcattCagcacatagtacttaagcag	11	9	11	10	1	2	0	2	0	0	0	2	1	2	0	1	2	4	5	1	2	3	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:1582626C>G	uc002fte.2	-	10	1482	c.1368G>C	c.(1366-1368)CTG>CTC	p.L456L		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	456						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCAGGGCATTCAGCACATAGT	0.542													8	66					0	0	0	0	G	1582626	G	G	1582626	2	3	221	1	0	0	0	0	0	0	0	1	12637	813	29	2		2	PRPF8	17	1582626	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	459	1582626	79612584	262	40788											
TP53	7157	broad.mit.edu	37	chr17	7577085	7577085	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgcggagattctcttcctCtgtgcgccggtctctcccag	3	13	10	15	3	3	1	0	0	3	1	7	2	5	1	3	2	2	0	3	2	0	3	rs112431538		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:7577085C>T	uc002gim.2	-	8	1047	c.853G>A	c.(853-855)GAG>AAG	p.E285K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E285K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E153K|TP53_uc010cng.1_Missense_Mutation_p.E153K|TP53_uc002gii.1_Missense_Mutation_p.E153K|TP53_uc010cnh.1_Missense_Mutation_p.E285K|TP53_uc010cni.1_Missense_Mutation_p.E285K|TP53_uc002gij.2_Missense_Mutation_p.E285K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	285	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(95)|p.E285*(16)|p.E285V(13)|p.0?(7)|p.E285Q(4)|p.E285E(3)|p.E285G(3)|p.E285A(2)|p.?(2)|p.R283fs*16(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.C275fs*20(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	23					0	0	0	0	T	7577085	T	T	7577085	3	4	221	1	0	0	0	0	1	0	0	0	16448	922	32	2	433	2	TP53	17	7577085	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	5994459	7577085	73618125	263	40789											
MYH10	4628	broad.mit.edu	37	chr17	8422110	8422110	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaattctaaagcccggatCtaagagagaaagagtttatt	15	11	8	7	1	2	3	0	0	2	3	3	5	3	4	2	1	1	1	2	1	6	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:8422110C>G	uc002gll.2	-	19	2347	c.2251_splice	c.e19-1	p.I751_splice	MYH10_uc002glm.2_Splice_Site_p.I782_splice|MYH10_uc010cnx.2_Splice_Site_p.I760_splice	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle						actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						AAGCCCGGATCTAAGAGAGAA	0.353													3	46					0	0	0	0	G	8422110	G	G	8422110	5	3	221	1	0	0	0	0	0	0	1	0	10083	927	32	2	3772	2	MYH10	17	8422110	Splice_Site	SNP	C	TCGA-CV-7099-01A-41D-2012-08	845025	8422110	72773100	264	40790											
MYH2	4620	broad.mit.edu	37	chr17	10442663	10442663	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggccagagcacctactgcGttggacaccttaaaagacaa	13	8	9	11	1	0	2	0	0	0	2	0	3	0	3	3	2	3	2	3	2	4	4	rs151000841	by1000genomes	TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:10442663G>A	uc010coi.2	-	14	1403	c.1275C>T	c.(1273-1275)AAC>AAT	p.N425N	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.N425N|MYH2_uc010coj.2_Silent_p.N425N	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	425	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CACCTACTGCGTTGGACACCT	0.468													18	118					0	0	0	0	A	10442663	A	A	10442663	2	1	221	1	0	0	0	0	0	0	0	1	10088	1136	40	1		1	MYH2	17	10442663	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	2020553	10442663	70752547	265	40791											
ATPAF2	91647	broad.mit.edu	37	chr17	17942267	17942267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catagaagcgctggggccacCcgccggccgattcaggagac	9	4	14	14	4	1	2	1	0	0	2	1	4	1	2	4	4	1	1	4	4	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:17942267C>T	uc002gse.1	-	1	214	c.61G>A	c.(61-63)GGT>AGT	p.G21S	C17orf39_uc002gsg.1_5'Flank|ATPAF2_uc002gsd.1_RNA|ATPAF2_uc002gsf.1_RNA|ATPAF2_uc010vxf.1_Missense_Mutation_p.G21S	NM_145691	NP_663729	Q8N5M1	ATPF2_HUMAN	ATP synthase mitochondrial F1 complex assembly	21					proton-transporting ATP synthase complex assembly	mitochondrion|nuclear speck	protein binding				0	all_neural(463;0.228)					CTGGGGCCACCCGCCGGCCGA	0.667													12	7					0	0	0	0	T	17942267	T	T	17942267	3	4	221	1	0	0	0	0	1	0	0	0	1203	623	22	4	840	4	ATPAF2	17	17942267	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	7499604	17942267	63252943	266	40792											
MYO15A	51168	broad.mit.edu	37	chr17	18039062	18039062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcctcagtggtgagtgcccGagagatccaggccgtggcag	7	6	17	11	2	1	2	1	1	0	1	2	4	2	2	4	4	1	1	4	4	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:18039062G>A	uc010vxh.1	+	12	4858	c.4520G>A	c.(4519-4521)CGA>CAA	p.R1507Q		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1507	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GTGAGTGCCCGAGAGATCCAG	0.522													7	24					0	0	0	0	A	18039062	A	A	18039062	3	1	221	1	0	0	0	0	1	0	0	0	10116	1058	37	1	4562	1	MYO15A	17	18039062	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	96795	18039062	63156148	267	40793											
CRYBA1	1411	broad.mit.edu	37	chr17	27581304	27581307	+	Frame_Shift_Del	DEL	GAGA	-	-																															ggaggagactataaacattgGagagagtggggctctcatgc																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:27581304_27581307delGAGA	uc002hdw.2	+	6	592_595	c.585_588delGAGA	c.(583-588)TGGAGAfs	p.W195fs		NM_005208	NP_005199	P05813	CRBA1_HUMAN	crystallin, beta A3	195_196	Beta/gamma crystallin 'Greek key' 4.				visual perception	soluble fraction	structural constituent of eye lens				0			BRCA - Breast invasive adenocarcinoma(11;3.3e-05)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			ATAAACATTGGAGAGAGTGGGGCT	0.441													---	---	---								-	27581307	-	-	27581304	7	5	221	1	0	1	0	1	0	0	0	0	3922	1183	41	0	607	0	CRYBA1	17	27581304	Frame_Shift_Del	DEL	GAGA	TCGA-CV-7099-01A-41D-2012-08	9542242	27581304	53613906	268	40794											
TTC25	83538	broad.mit.edu	37	chr17	40087031	40087031	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctttccctcttatatggccGaaggcgagcggctctacctg	6	11	10	14	3	2	0	0	0	2	0	3	2	3	0	4	3	2	1	4	3	4	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:40087031G>A	uc002hyj.3	+	1	144	c.55G>A	c.(55-57)GAA>AAA	p.E19K	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Missense_Mutation_p.E19K	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	19	TPR 1.					cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				TTATATGGCCGAAGGCGAGCG	0.542													5	8					0	0	0	0	A	40087031	A	A	40087031	3	1	221	1	0	0	0	0	1	0	0	0	16761	1059	37	1	57	1	TTC25	17	40087031	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	12505727	40087031	41108179	269	40795											
BRCA1	672	broad.mit.edu	37	chr17	41246860	41246860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtatttgttacatccgtctCagaaaattcacaagcagctg	13	12	7	9	1	2	1	2	0	1	1	4	1	3	1	1	0	3	4	1	0	5	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:41246860C>G	uc002icq.2	-	10	920	c.688G>C	c.(688-690)GAG>CAG	p.E230Q	BRCA1_uc010whp.1_Missense_Mutation_p.E183Q|BRCA1_uc010whl.1_Missense_Mutation_p.E230Q|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.E159Q|BRCA1_uc002icu.2_Missense_Mutation_p.E230Q|BRCA1_uc010cyx.2_Missense_Mutation_p.E183Q|BRCA1_uc002ict.2_Missense_Mutation_p.E230Q|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Missense_Mutation_p.E62Q|BRCA1_uc002idc.1_Missense_Mutation_p.E229Q|BRCA1_uc010whr.1_Missense_Mutation_p.E183Q|BRCA1_uc002idd.2_Missense_Mutation_p.E230Q|BRCA1_uc002ide.1_Missense_Mutation_p.E61Q|BRCA1_uc010cyy.1_Missense_Mutation_p.E230Q|BRCA1_uc010whs.1_Missense_Mutation_p.E230Q|BRCA1_uc010cyz.2_Missense_Mutation_p.E183Q|BRCA1_uc010cza.2_Missense_Mutation_p.E204Q|BRCA1_uc010wht.1_5'UTR	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	230					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ACATCCGTCTCAGAAAATTCA	0.368			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			9	15					0	0	0	0	G	41246860	G	G	41246860	3	3	221	1	0	0	0	0	1	0	0	0	1503	835	29	2	5029	2	BRCA1	17	41246860	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1159829	41246860	39948350	270	40796											
SP6	80320	broad.mit.edu	37	chr17	45924944	45924944	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagaagagccagttgcacacGaagggacggtcgccgctgtg	10	5	15	11	4	0	2	0	0	0	2	1	4	0	3	2	2	2	3	2	2	2	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:45924944G>A	uc002img.1	-	2	1184	c.852C>T	c.(850-852)TTC>TTT	p.F284F	SP6_uc002imh.1_Silent_p.F284F	NM_199262	NP_954871	Q3SY56	SP6_HUMAN	Sp6 transcription factor	284	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						AGTTGCACACGAAGGGACGGT	0.652													14	35					0	0	0	0	A	45924944	A	A	45924944	2	1	221	1	0	0	0	0	0	0	0	1	15032	1049	37	1		1	SP6	17	45924944	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4678084	45924944	35270266	271	40797											
HOXB5	3215	broad.mit.edu	37	chr17	46670537	46670537	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatttgcggagtctgcccctCgggcgcggctgtggaggtgg	3	10	18	10	4	1	0	0	0	1	0	2	2	1	2	2	6	2	1	2	6	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:46670537C>T	uc002inr.2	-	1	567	c.508G>A	c.(508-510)GAG>AAG	p.E170K	HOXB3_uc010wlm.1_5'Flank|HOXB3_uc010dbf.2_5'Flank|HOXB3_uc010dbg.2_5'Flank	NM_002147	NP_002138	P09067	HXB5_HUMAN	homeobox B5	170						nucleus	sequence-specific DNA binding				0						GTCTGCCCCTCGGGCGCGGCT	0.607													16	45					0	0	0	0	T	46670537	T	T	46670537	3	4	221	1	0	0	0	0	1	0	0	0	7343	893	31	1	309	1	HOXB5	17	46670537	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	745593	46670537	34524673	272	40798											
EPN3	55040	broad.mit.edu	37	chr17	48615544	48615544	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggccctcgccatgagccgtGaggaggcagagaaggtgagg	9	5	18	9	2	0	4	0	3	0	1	1	6	0	5	3	5	1	1	3	5	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:48615544G>A	uc002ira.3	+	3	1102	c.667G>A	c.(667-669)GAG>AAG	p.E223K	EPN3_uc010wms.1_Missense_Mutation_p.E278K|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.E223K	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	223	UIM 1.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CATGAGCCGTGAGGAGGCAGA	0.667													7	24					0	0	0	0	A	48615544	A	A	48615544	3	1	221	1	0	0	0	0	1	0	0	0	5211	1291	45	2	673	2	EPN3	17	48615544	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1945007	48615544	32579666	273	40799											
HELZ	9931	broad.mit.edu	37	chr17	65105306	65105306	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gatgtgaaggaagaatggggCcgggttgtgcaatggctctc	9	9	17	6	1	1	2	0	1	1	1	2	4	1	3	1	5	1	3	1	5	4	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:65105306C>T	uc010wqk.1	-	29	4605	c.4418G>A	c.(4417-4419)GGC>GAC	p.G1473D	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.G1472D|HELZ_uc010der.2_Missense_Mutation_p.G16D	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AAGAATGGGGCCGGGTTGTGC	0.532													5	69					0	0	0	0	T	65105306	T	T	65105306	3	4	221	1	0	0	0	0	1	0	0	0	7088	739	26	4	1433	4	HELZ	17	65105306	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	16489762	65105306	16089904	274	40800											
BTBD17	388419	broad.mit.edu	37	chr17	72353305	72353305	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagttgcggggcaggaaggCgctgccgttgacgtcgaaga	8	7	18	8	5	0	2	0	1	0	1	1	4	0	3	1	4	2	5	1	4	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:72353305C>T	uc002jkn.2	-	3	928	c.928G>A	c.(928-930)GCC>ACC	p.A310T		NM_001080466	NP_001073935	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17 precursor	310						extracellular region					0						GGCAGGAAGGCGCTGCCGTTG	0.716													5	11					0	0	0	0	T	72353305	T	T	72353305	3	4	221	1	0	0	0	0	1	0	0	0	1547	768	27	1	512	1	BTBD17	17	72353305	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	7247999	72353305	8841905	275	40801											
RAB37	326624	broad.mit.edu	37	chr17	72741479	72741479	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggccgggcatcaggcggatGagcccagcttccagatccga	8	5	15	13	3	1	2	1	1	0	1	3	4	3	3	4	4	2	2	4	4	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:72741479G>A	uc002jlk.2	+	9	657	c.601G>A	c.(601-603)GAG>AAG	p.E201K	RAB37_uc002jlc.2_3'UTR|RAB37_uc010dfu.2_Missense_Mutation_p.E194K|RAB37_uc002jld.2_3'UTR|RAB37_uc010wrb.1_Missense_Mutation_p.E169K|RAB37_uc010wrc.1_Missense_Mutation_p.E206K|RAB37_uc010wrd.1_Missense_Mutation_p.E169K|RAB37_uc010wre.1_Missense_Mutation_p.E164K|RAB37_uc002jll.3_RNA	NM_001006638	NP_001006639	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family isoform 2	201					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			ovary(1)	1						TCAGGCGGATGAGCCCAGCTT	0.507											OREG0024716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	49					0	0	0	0	A	72741479	A	A	72741479	3	1	221	1	0	0	0	0	1	0	0	0	12992	1291	45	2	938	2	RAB37	17	72741479	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	388174	72741479	8453731	276	40802											
FOXJ1	2302	broad.mit.edu	37	chr17	74136166	74136166	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcggggggtggggcctgcAgccccgggggcgcgctccgc	1	4	21	15	6	0	0	0	0	0	0	2	0	1	0	4	7	2	2	4	7	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:74136166A>C	uc002jqw.2	-	1	401	c.311T>G	c.(310-312)CTG>CGG	p.L104R	FOXJ1_uc002jqx.2_Missense_Mutation_p.L104R|uc002jqy.1_5'Flank	NM_001454	NP_001445	Q92949	FOXJ1_HUMAN	forkhead box J1	104					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			pancreas(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			TGGGGCCTGCAGCCCCGGGGG	0.736													4	24					0	0	0	0	C	74136166	C	C	74136166	3	2	221	1	0	0	0	0	1	0	0	0	6045	188	7	5	962	5	FOXJ1	17	74136166	Missense_Mutation	SNP	A	TCGA-CV-7099-01A-41D-2012-08	1394687	74136166	7059044	277	40803											
C1QTNF1	114897	broad.mit.edu	37	chr17	77043984	77043984	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacgaggaggaggtggtgatCttgttcgcgcaggtgggcga	8	8	19	6	4	1	1	0	1	1	0	2	5	1	3	0	6	1	2	0	6	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr17:77043984C>G	uc002jwp.2	+	4	1000	c.660C>G	c.(658-660)ATC>ATG	p.I220M	C1QTNF1_uc002jwq.2_Missense_Mutation_p.I138M|C1QTNF1_uc002jwr.3_Missense_Mutation_p.I230M|C1QTNF1_uc002jws.2_Missense_Mutation_p.I220M|C1QTNF1_uc002jwt.2_Missense_Mutation_p.I318M	NM_030968	NP_112230	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	220	C1q.					collagen				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			AGGTGGTGATCTTGTTCGCGC	0.597													29	54					0	0	0	0	G	77043984	G	G	77043984	3	3	221	1	0	0	0	0	1	0	0	0	1971	903	32	2	670	2	C1QTNF1	17	77043984	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2907818	77043984	4151226	278	40804											
COLEC12	81035	broad.mit.edu	37	chr18	346549	346549	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagattgctggtcagcgtcCgcaggtggtgggctgtgtaa	6	12	16	7	2	1	1	1	0	0	1	2	1	2	1	1	4	2	4	1	4	2	3	rs140999458		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr18:346549C>T	uc002kkm.2	-	5	1288	c.1073G>A	c.(1072-1074)CGG>CAG	p.R358Q		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	358	Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GGTCAGCGTCCGCAGGTGGTG	0.473													18	46					0	0	0	0	T	346549	T	T	346549	3	4	221	1	0	0	0	0	1	0	0	0	3727	652	23	1	1179	1	COLEC12	18	346549	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08		346549	77730699	279	40805											
LAMA3	3909	broad.mit.edu	37	chr18	21293932	21293932	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aagaccccaggaaagcacatCctgtcaccaatgccatcgat	14	6	7	14	1	1	1	1	0	0	1	3	3	2	2	5	1	2	1	5	1	3	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr18:21293932C>G	uc002kuq.2	+	2	429	c.343C>G	c.(343-345)CCT>GCT	p.P115A	LAMA3_uc010dlv.1_Missense_Mutation_p.P115A|LAMA3_uc002kur.2_Missense_Mutation_p.P115A	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	115	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAAAGCACATCCTGTCACCAA	0.438													10	26					0	0	0	0	G	21293932	G	G	21293932	3	3	221	1	0	0	0	0	1	0	0	0	8647	855	30	2	349	2	LAMA3	18	21293932	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	20947383	21293932	56783316	280	40806											
DCC	1630	broad.mit.edu	37	chr18	50278591	50278591	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctggccttgggaatggatGaaaggaagcagcaactttca	13	9	12	7	0	2	1	1	1	1	0	2	4	2	4	1	4	3	2	1	4	4	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr18:50278591G>A	uc002lfe.1	+	2	846	c.259G>A	c.(259-261)GAA>AAA	p.E87K	DCC_uc010xdr.1_5'UTR	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	87	Extracellular (Potential).|Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GGGAATGGATGAAAGGAAGCA	0.498													25	58					0	0	0	0	A	50278591	A	A	50278591	3	1	221	1	0	0	0	0	1	0	0	0	4299	1291	45	2	265	2	DCC	18	50278591	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	28984659	50278591	27798657	281	40807											
WDR7	23335	broad.mit.edu	37	chr18	54483274	54483274	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttttagctggagtcacatCagaagccgcgcagactatca	11	10	10	10	2	3	2	3	0	0	2	3	3	3	3	1	1	2	3	1	1	3	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr18:54483274C>G	uc002lgk.1	+	20	3414	c.3203C>G	c.(3202-3204)TCA>TGA	p.S1068*	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Nonsense_Mutation_p.S1035*	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1068										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GGAGTCACATCAGAAGCCGCG	0.418													12	21					0	0	0	0	G	54483274	G	G	54483274	4	3	221	1	0	0	0	0	0	1	0	0	17388	838	29	2	3277	2	WDR7	18	54483274	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	4204683	54483274	23593974	282	40808											
NFATC1	4772	broad.mit.edu	37	chr18	77193713	77193713	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccggggggccgtgaaggcgtCggccggaggacaccccatcg	6	3	18	14	6	0	1	0	1	0	0	2	3	0	3	5	7	0	0	5	7	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr18:77193713C>T	uc010xfg.1	+	3	1814	c.1361C>T	c.(1360-1362)TCG>TTG	p.S454L	NFATC1_uc002lnc.1_Missense_Mutation_p.S454L|NFATC1_uc010xff.1_Missense_Mutation_p.S454L|NFATC1_uc002lnd.2_Missense_Mutation_p.S454L|NFATC1_uc002lne.2_5'UTR|NFATC1_uc010xfh.1_Missense_Mutation_p.S454L|NFATC1_uc010xfi.1_Missense_Mutation_p.S441L|NFATC1_uc010xfj.1_5'UTR|NFATC1_uc002lnf.2_Missense_Mutation_p.S441L|NFATC1_uc002lng.2_Missense_Mutation_p.S441L|NFATC1_uc010xfk.1_Missense_Mutation_p.S441L	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	454	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GTGAAGGCGTCGGCCGGAGGA	0.622													29	72					0	0	0	0	T	77193713	T	T	77193713	3	4	221	1	0	0	0	0	1	0	0	0	10415	893	31	1	1463	1	NFATC1	18	77193713	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	22710439	77193713	883535	283	40809											
S1PR4	8698	broad.mit.edu	37	chr19	3179318	3179318	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggctgctggccgcgctgctGgggatgctgcctttgctggg	1	11	18	11	2	0	0	0	0	0	0	0	1	0	1	2	5	5	6	2	5	0	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:3179318G>A	uc002lxg.2	+	1	553	c.528G>A	c.(526-528)CTG>CTA	p.L176L		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	176	Helical; Name=4; (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						CCGCGCTGCTGGGGATGCTGC	0.667													12	134					0	0	0	0	A	3179318	A	A	3179318	2	1	221	1	0	0	0	0	0	0	0	1	13861	1335	47	4		4	S1PR4	19	3179318	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08		3179318	55949665	284	40810											
C3	718	broad.mit.edu	37	chr19	6684804	6684804	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accgacaaggtgccttggccTtttccttcagctgtgactgt	6	13	10	12	1	1	1	1	1	0	0	2	2	2	1	4	2	2	1	4	2	1	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:6684804T>C	uc002mfm.2	-	31	4073	c.4011A>G	c.(4009-4011)AAA>AAG	p.K1337K	C3_uc002mfl.2_Silent_p.K73K	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1337					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGCCTTGGCCTTTTCCTTCAG	0.537													3	137					0	0	0	0	C	6684804	C	C	6684804	2	2	221	1	0	0	0	0	0	0	0	1	2214	1606	56	5		5	C3	19	6684804	Silent	SNP	T	TCGA-CV-7099-01A-41D-2012-08	3505486	6684804	52444179	285	40811											
EMR1	2015	broad.mit.edu	37	chr19	6916361	6916361	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatcgggtgttccacaattGaggaatctgaatccacaggt	12	10	11	8	1	1	3	0	2	1	1	4	4	3	4	2	3	0	1	2	3	3	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:6916361G>C	uc002mfw.2	+	12	1440	c.1402G>C	c.(1402-1404)GAG>CAG	p.E468Q	EMR1_uc010dvc.2_Missense_Mutation_p.E468Q|EMR1_uc010dvb.2_Missense_Mutation_p.E416Q|EMR1_uc010xji.1_Missense_Mutation_p.E327Q|EMR1_uc010xjj.1_Missense_Mutation_p.E291Q	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	468	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TTCCACAATTGAGGAATCTGA	0.348													38	81					0	0	0	0	C	6916361	C	C	6916361	3	2	221	1	0	0	0	0	1	0	0	0	5128	1291	45	2	1448	2	EMR1	19	6916361	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	231557	6916361	52212622	286	40812											
MCOLN1	57192	broad.mit.edu	37	chr19	7593497	7593497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcaggagacaacagcttcCggctcctgtttgacgtggtg	7	9	13	12	3	0	2	0	1	0	1	2	3	2	2	3	3	2	4	3	3	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:7593497C>T	uc002mgo.2	+	8	1017	c.892C>T	c.(892-894)CGG>TGG	p.R298W	MCOLN1_uc002mgp.2_Missense_Mutation_p.R263W	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	298	Helical; (Potential).				calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						CAACAGCTTCCGGCTCCTGTT	0.632													10	30					0	0	0	0	T	7593497	T	T	7593497	3	4	221	1	0	0	0	0	1	0	0	0	9448	643	23	1	922	1	MCOLN1	19	7593497	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	677136	7593497	51535486	287	40813											
NOTCH3	4854	broad.mit.edu	37	chr19	15291045	15291045	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacactgcccacccgcctgAcacagctgctccagccgcac	9	4	7	21	2	0	1	0	1	0	0	1	1	1	1	5	0	4	3	5	0	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:15291045A>G	uc002nan.2	-	20	3241	c.3165T>C	c.(3163-3165)TGT>TGC	p.C1055C	NOTCH3_uc002nao.1_Silent_p.C1003C	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1055	Extracellular (Potential).|EGF-like 27.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CACCCGCCTGACACAGCTGCT	0.597													3	44					0	0	0	0	G	15291045	G	G	15291045	2	3	221	1	0	0	0	0	0	0	0	1	10604	273	10	5		5	NOTCH3	19	15291045	Silent	SNP	A	TCGA-CV-7099-01A-41D-2012-08	7697548	15291045	43837938	288	40814											
DDA1	79016	broad.mit.edu	37	chr19	17430407	17430407	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggagctggaaggcgagagctCcgcacctccccgcaaggtgg	8	4	16	13	3	0	1	0	0	0	1	2	4	2	3	4	5	2	4	4	5	2	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:17430407C>G	uc002ngd.2	+	5	378	c.251C>G	c.(250-252)TCC>TGC	p.S84C	DDA1_uc002nge.2_Silent_p.L22L	NM_024050	NP_076955	Q9BW61	DDA1_HUMAN	DET1 and DDB1 associated 1	84										ovary(1)	1						GGCGAGAGCTCCGCACCTCCC	0.587													3	9					0	0	0	0	G	17430407	G	G	17430407	3	3	221	1	0	0	0	0	1	0	0	0	4337	855	30	2	269	2	DDA1	19	17430407	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2139362	17430407	41698576	289	40815											
SLC27A1	376497	broad.mit.edu	37	chr19	17615340	17615340	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acctcagaccggctcttcttCctggacctgaagcagggcca	8	8	10	15	1	3	2	1	1	2	1	4	3	4	3	5	3	1	2	5	3	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:17615340C>T	uc002ngu.1	+	12	1910	c.1860C>T	c.(1858-1860)TTC>TTT	p.F620F	SLC27A1_uc010xpp.1_Silent_p.F441F|SLC27A1_uc002ngv.1_Silent_p.F222F	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	620	Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0						GGCTCTTCTTCCTGGACCTGA	0.597													24	65					0	0	0	0	T	17615340	T	T	17615340	2	4	221	1	0	0	0	0	0	0	0	1	14589	854	30	2		2	SLC27A1	19	17615340	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	184933	17615340	41513643	290	40816											
PDE4C	5143	broad.mit.edu	37	chr19	18324232	18324232	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaccgaggcttgtcaccttCttggtctccaccatggtctt	6	13	8	14	1	4	0	1	0	3	0	5	1	4	0	4	3	0	1	4	3	0	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:18324232C>G	uc010xqc.1	-	13	2034	c.1554G>C	c.(1552-1554)AAG>AAC	p.K518N	PDE4C_uc002nik.3_Missense_Mutation_p.K518N|PDE4C_uc002nil.3_Missense_Mutation_p.K518N|PDE4C_uc002nif.3_Missense_Mutation_p.K287N|PDE4C_uc002nig.3_Missense_Mutation_p.K233N|PDE4C_uc002nih.3_Missense_Mutation_p.K288N|PDE4C_uc010ebk.2_Missense_Mutation_p.K412N|PDE4C_uc002nii.3_Missense_Mutation_p.K486N|PDE4C_uc010ebl.2_Missense_Mutation_p.K232N	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	518					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	TTGTCACCTTCTTGGTCTCCA	0.542													15	19					0	0	0	0	G	18324232	G	G	18324232	3	3	221	1	0	0	0	0	1	0	0	0	11695	912	32	2	596	2	PDE4C	19	18324232	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	708892	18324232	40804751	291	40817											
LSR	51599	broad.mit.edu	37	chr19	35739867	35739867	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctggccttggtgcgcgcCgcgccccctaaggtactttg	3	10	12	16	4	0	0	0	0	0	0	1	0	1	0	5	3	2	1	5	3	2	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:35739867C>G	uc002nyl.2	+	1	309	c.86C>G	c.(85-87)CCG>CGG	p.P29R	LSR_uc002nym.2_Missense_Mutation_p.P29R|LSR_uc002nyn.2_Missense_Mutation_p.P29R|LSR_uc002nyo.2_Missense_Mutation_p.P29R|LSR_uc010xsr.1_Missense_Mutation_p.P29R|LSR_uc002nyp.2_Missense_Mutation_p.P29R	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	29	Extracellular (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TGGTGCGCGCCGCGCCCCCTA	0.662													4	27					0	0	0	0	G	35739867	G	G	35739867	3	3	221	1	0	0	0	0	1	0	0	0	9114	652	23	3	88	3	LSR	19	35739867	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	17415635	35739867	23389116	292	40818											
KIRREL2	84063	broad.mit.edu	37	chr19	36352524	36352524	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagtgtctggttttcgcctCtcccgccccagatgccgtgg	3	11	11	16	3	2	1	0	0	2	1	4	1	2	1	6	2	1	1	6	2	0	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:36352524C>T	uc002ocb.3	+	10	1483	c.1271C>T	c.(1270-1272)TCT>TTT	p.S424F	KIRREL2_uc002obz.3_Missense_Mutation_p.S424F|KIRREL2_uc002oca.3_Missense_Mutation_p.S374F|KIRREL2_uc002occ.3_Missense_Mutation_p.S371F|KIRREL2_uc002ocd.3_Missense_Mutation_p.S421F	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	424	Ig-like C2-type 5.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTTTTCGCCTCTCCCGCCCCA	0.642													38	104					0	0	0	0	T	36352524	T	T	36352524	3	4	221	1	0	0	0	0	1	0	0	0	8364	913	32	2	1309	2	KIRREL2	19	36352524	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	612657	36352524	22776459	293	40819											
ZFP14	57677	broad.mit.edu	37	chr19	36853091	36853091	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcaggatccaggaattccCattcttcctgtgagaagtct	10	11	10	10	0	2	1	0	1	2	1	5	5	5	3	3	2	1	1	3	2	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:36853091C>T	uc002odx.1	-	2	152	c.59G>A	c.(58-60)TGG>TAG	p.W20*	ZFP14_uc010xtd.1_Nonsense_Mutation_p.W20*|ZFP14_uc010eex.1_Nonsense_Mutation_p.W20*	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					CAGGAATTCCCATTCTTCCTG	0.378													5	49					0	0	0	0	T	36853091	T	T	36853091	4	4	221	1	0	0	0	0	0	1	0	0	17706	595	21	4	1554	4	ZFP14	19	36853091	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	500567	36853091	22275892	294	40820											
ZNF540	163255	broad.mit.edu	37	chr19	38103198	38103198	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggaaagcttttagtgtatgCggacaacttacccgtcatca	11	11	10	9	2	2	0	2	0	0	0	2	2	2	2	1	2	4	2	1	2	5	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:38103198C>T	uc002ogq.2	+	5	1349	c.1017C>T	c.(1015-1017)TGC>TGT	p.C339C	ZNF540_uc002ogu.2_Silent_p.C339C|ZNF540_uc010efq.2_Silent_p.C307C	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	339	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTAGTGTATGCGGACAACTTA	0.353													5	58					0	0	0	0	T	38103198	T	T	38103198	2	4	221	1	0	0	0	0	0	0	0	1	18042	776	27	1		1	ZNF540	19	38103198	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1250107	38103198	21025785	295	40821											
RYR1	6261	broad.mit.edu	37	chr19	39017636	39017636	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggctctgtctccccagaaaGacacagatgaggaggtccgg	10	7	13	11	1	2	4	0	1	2	3	4	5	3	5	3	4	0	1	3	4	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:39017636G>C	uc002oit.2	+	72	10760	c.10630G>C	c.(10630-10632)GAC>CAC	p.D3544H	RYR1_uc002oiu.2_Missense_Mutation_p.D3539H|RYR1_uc002oiv.1_Missense_Mutation_p.D459H|RYR1_uc010xuf.1_Missense_Mutation_p.D464H	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3544					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCCCCAGAAAGACACAGATGA	0.542													10	43					0	0	0	0	C	39017636	C	C	39017636	3	2	221	1	0	0	0	0	1	0	0	0	13833	942	33	2	10916	2	RYR1	19	39017636	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	914438	39017636	20111347	296	40822											
CYP2A13	1553	broad.mit.edu	37	chr19	41596383	41596383	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccattgtctttggggacCgctttgactatgaggacaaa	9	12	11	9	1	1	2	0	2	1	0	2	4	2	4	2	3	0	2	2	3	2	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:41596383C>T	uc002opt.2	+	4	577	c.568C>T	c.(568-570)CGC>TGC	p.R190C		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	190					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	CTTTGGGGACCGCTTTGACTA	0.567													30	74					0	0	0	0	T	41596383	T	T	41596383	3	4	221	1	0	0	0	0	1	0	0	0	4178	652	23	1	582	1	CYP2A13	19	41596383	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	2578747	41596383	17532600	297	40823											
ATP1A3	478	broad.mit.edu	37	chr19	42485787	42485787	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcatccccagccacatccCtctgcaaggagaaagggttg	11	6	10	14	1	1	1	0	0	1	1	3	2	3	1	4	2	2	3	4	2	2	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:42485787C>T	uc002osg.2	-	11	1458	c.1304G>A	c.(1303-1305)AGG>AAG	p.R435K	ATP1A3_uc010xwf.1_Missense_Mutation_p.R446K|ATP1A3_uc010xwg.1_Missense_Mutation_p.R405K|ATP1A3_uc010xwh.1_Missense_Mutation_p.R448K|ATP1A3_uc002osh.2_Missense_Mutation_p.R435K	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	435	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						AGCCACATCCCTCTGCAAGGA	0.592													5	32					0	0	0	0	T	42485787	T	T	42485787	3	4	221	1	0	0	0	0	1	0	0	0	1132	695	24	4	1789	4	ATP1A3	19	42485787	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	889404	42485787	16643196	298	40824											
CIC	23152	broad.mit.edu	37	chr19	42794752	42794752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgtgggtggcctggagcCaccaggcccctcagtcatcg	7	7	14	13	1	2	0	2	0	0	0	3	1	2	1	5	4	1	0	5	4	1	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:42794752C>T	uc002otf.1	+	10	1872	c.1832C>T	c.(1831-1833)CCA>CTA	p.P611L		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	611	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				GGCCTGGAGCCACCAGGCCCC	0.657			T	DUX4	soft tissue sarcoma								8	103					0	0	0	0	T	42794752	T	T	42794752	3	4	221	1	0	0	0	0	1	0	0	0	3439	594	21	4	1870	4	CIC	19	42794752	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	308965	42794752	16334231	299	40825											
ZNF155	7711	broad.mit.edu	37	chr19	44500612	44500612	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagagagtccacgtgggagaGaaactctttatgtgtgatgt	11	11	13	6	1	1	3	0	1	1	2	2	6	2	4	1	1	1	0	1	1	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:44500612G>C	uc002oxy.1	+	5	808	c.603G>C	c.(601-603)GAG>GAC	p.E201D	ZNF155_uc002oxz.1_Missense_Mutation_p.E201D|ZNF155_uc010xwt.1_Missense_Mutation_p.E212D	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	201						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				ACGTGGGAGAGAAACTCTTTA	0.413													35	135					0	0	0	0	C	44500612	C	C	44500612	3	2	221	1	0	0	0	0	1	0	0	0	17803	933	33	2	617	2	ZNF155	19	44500612	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1705860	44500612	14628371	300	40826											
CD3EAP	10849	broad.mit.edu	37	chr19	45910389	45910389	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtccccccaactttaccgcGaagcccccagcctcagagtc	8	7	7	19	2	1	1	1	0	0	1	3	2	2	1	7	0	4	0	7	0	3	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:45910389G>A	uc002pbq.1	+	2	548	c.60G>A	c.(58-60)GCG>GCA	p.A20A	PPP1R13L_uc002pbn.2_5'Flank|PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Silent_p.A22A	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	20					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		ACTTTACCGCGAAGCCCCCAG	0.612													30	76					0	0	0	0	A	45910389	A	A	45910389	2	1	221	1	0	0	0	0	0	0	0	1	3027	1045	37	1		1	CD3EAP	19	45910389	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1409777	45910389	13218594	301	40827											
PRRG2	5639	broad.mit.edu	37	chr19	50087180	50087180	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccctcaaggagcgcttttGggagagctacatctacaatg	10	9	10	12	1	2	1	1	0	1	1	2	3	2	2	2	2	4	2	2	2	4	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:50087180G>T	uc002pon.3	+	4	437	c.272G>T	c.(271-273)TGG>TTG	p.W91L	PRRG2_uc010yaz.1_Missense_Mutation_p.W68L	NM_000951	NP_000942	O14669	TMG2_HUMAN	proline rich Gla (G-carboxyglutamic acid) 2	91	Gla.|Extracellular (Potential).					extracellular region|integral to plasma membrane	calcium ion binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0121)		GAGCGCTTTTGGGAGAGCTAC	0.527													6	82					0.00198382	0.00275882	1	0	T	50087180	T	T	50087180	3	4	221	1	0	0	0	0	1	0	0	0	12668	1357	47	4	282	4	PRRG2	19	50087180	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4176791	50087180	9041803	302	40828											
ZNF836	162962	broad.mit.edu	37	chr19	52659522	52659522	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccttgccacattcattgcAtttgtaaggtttctctccag	8	15	7	11	0	2	0	1	0	1	0	4	1	3	0	3	1	2	3	3	1	1	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:52659522A>G	uc010ydi.1	-	5	1788	c.1414T>C	c.(1414-1416)TGC>CGC	p.C472R	ZNF836_uc010ydj.1_Missense_Mutation_p.C472R	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	472	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATTCATTGCATTTGTAAGGT	0.418													11	131					0	0	0	0	G	52659522	G	G	52659522	3	3	221	1	0	0	0	0	1	0	0	0	18254	217	8	5	1398	5	ZNF836	19	52659522	Missense_Mutation	SNP	A	TCGA-CV-7099-01A-41D-2012-08	2572342	52659522	6469461	303	40829											
ZNF415	55786	broad.mit.edu	37	chr19	53612343	53612343	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctccaatatgagttttctGatgtagtgcaaggcatgaat	11	14	9	7	0	2	3	0	3	2	0	3	3	2	3	1	1	1	4	1	1	5	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:53612343G>A	uc002qax.2	-	7	1448	c.1099C>T	c.(1099-1101)CAG>TAG	p.Q367*	ZNF415_uc002qat.2_Nonsense_Mutation_p.Q331*|ZNF415_uc002qaw.2_Nonsense_Mutation_p.Q319*|ZNF415_uc010yds.1_Nonsense_Mutation_p.Q319*|ZNF415_uc010ydt.1_Nonsense_Mutation_p.Q319*|ZNF415_uc002qau.2_Nonsense_Mutation_p.Q306*|ZNF415_uc002qav.2_Nonsense_Mutation_p.Q331*|ZNF415_uc002qba.2_Nonsense_Mutation_p.Q89*|ZNF415_uc002qay.2_Nonsense_Mutation_p.Q306*|ZNF415_uc002qaz.2_Nonsense_Mutation_p.Q367*	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	367	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		TGAGTTTTCTGATGTAGTGCA	0.418													21	44					0	0	0	0	A	53612343	A	A	53612343	4	1	221	1	0	0	0	0	0	1	0	0	17959	1299	45	2	716	2	ZNF415	19	53612343	Nonsense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	952821	53612343	5516640	304	40830											
ZNF582	147948	broad.mit.edu	37	chr19	56896256	56896256	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttttgccagaagtcttttCtacatttattatacccaaaa	12	16	3	10	0	2	1	0	0	2	1	2	1	2	1	3	0	3	0	3	0	7	9			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:56896256C>G	uc002qmz.1	-	5	689	c.530G>C	c.(529-531)AGA>ACA	p.R177T	ZNF582_uc002qmy.2_Missense_Mutation_p.R208T	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	177	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		GAAGTCTTTTCTACATTTATT	0.328													27	47					0	0	0	0	G	56896256	G	G	56896256	3	3	221	1	0	0	0	0	1	0	0	0	18081	913	32	2	1027	2	ZNF582	19	56896256	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	3283913	56896256	2232727	305	40831											
ZNF274	10782	broad.mit.edu	37	chr19	58721350	58721350	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcctgcaggacaacctgccGagggcaccacctgctgcctc	7	7	10	17	1	0	0	0	0	0	0	2	2	1	1	6	2	5	3	6	2	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:58721350G>A	uc002qrq.1	+	8	1222	c.763G>A	c.(763-765)GAG>AAG	p.E255K	ZNF274_uc010yhu.1_RNA|ZNF274_uc010yhv.1_RNA|ZNF274_uc002qrr.1_Missense_Mutation_p.E223K|ZNF274_uc002qrs.1_Missense_Mutation_p.E150K|ZNF274_uc010eum.1_Missense_Mutation_p.E14K	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	255					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		ACAACCTGCCGAGGGCACCAC	0.637													10	27					0	0	0	0	A	58721350	A	A	58721350	3	1	221	1	0	0	0	0	1	0	0	0	17876	1059	37	1	780	1	ZNF274	19	58721350	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1825094	58721350	407633	306	40832											
ZNF584	201514	broad.mit.edu	37	chr19	58928446	58928446	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattctgaagagagacccttCagatgcccaacaggcagaag	14	6	10	11	0	2	5	1	1	1	4	2	6	2	5	2	1	2	1	2	1	3	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:58928446C>T	uc002qsp.2	+	4	1013	c.561C>T	c.(559-561)TTC>TTT	p.F187F	ZNF584_uc010yia.1_RNA|ZNF584_uc002qsr.2_Silent_p.F142F|ZNF584_uc010yib.1_3'UTR	NM_173548	NP_775819	Q8IVC4	ZN584_HUMAN	zinc finger protein 584	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;5.3e-17)|all_epithelial(17;3.71e-12)|Lung NSC(17;8.3e-05)|Colorectal(82;0.000147)|all_lung(17;0.000386)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0271)		AGAGACCCTTCAGATGCCCAA	0.468													10	31					0	0	0	0	T	58928446	T	T	58928446	2	4	221	1	0	0	0	0	0	0	0	1	18083	825	29	2		2	ZNF584	19	58928446	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	207096	58928446	200537	307	40833											
ZNF324B	388569	broad.mit.edu	37	chr19	58967529	58967529	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgctctgcggtgctgccttCagccagggctcctcgctctt	2	11	12	16	3	3	0	1	0	2	0	5	0	4	0	3	2	4	4	3	2	0	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr19:58967529C>T	uc002qsv.1	+	4	1325	c.1218C>T	c.(1216-1218)TTC>TTT	p.F406F	ZNF324B_uc002qsu.1_Silent_p.F396F|ZNF324B_uc010euq.1_Silent_p.F406F	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	406	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GTGCTGCCTTCAGCCAGGGCT	0.662													5	58					0	0	0	0	T	58967529	T	T	58967529	2	4	221	1	0	0	0	0	0	0	0	1	17912	825	29	2		2	ZNF324B	19	58967529	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	39083	58967529	161454	308	40834											
RALGAPA2	57186	broad.mit.edu	37	chr20	20453517	20453517	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacttcacagccctgctggcGttgatgcacgtggcacatac	8	9	10	14	2	1	1	1	1	0	0	1	1	1	1	1	2	4	4	1	2	1	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr20:20453517G>A	uc002wrz.2	-	37	5594	c.5451C>T	c.(5449-5451)AAC>AAT	p.N1817N	RALGAPA2_uc010gcx.2_Silent_p.N1521N|RALGAPA2_uc010zsg.1_Silent_p.N1265N|RALGAPA2_uc002wsa.1_Silent_p.N589N	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1817	Rap-GAP.				activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						CCCTGCTGGCGTTGATGCACG	0.468													15	36					0	0	0	0	A	20453517	A	A	20453517	2	1	221	1	0	0	0	0	0	0	0	1	13079	1136	40	1		1	RALGAPA2	20	20453517	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08		20453517	42572003	309	40835											
CST1	1469	broad.mit.edu	37	chr20	23729656	23729656	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcatcaggaacgtaccttCtgcagttctggctgttcatg	7	13	10	11	1	4	0	2	0	2	0	4	1	4	1	1	2	4	6	1	2	2	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr20:23729656C>G	uc002wtp.2	-	2	410	c.339G>C	c.(337-339)CAG>CAC	p.Q113H		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	113						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					AACGTACCTTCTGCAGTTCTG	0.532													8	165					0	0	0	0	G	23729656	G	G	23729656	3	3	221	1	0	0	0	0	1	0	0	0	3987	912	32	2	94	2	CST1	20	23729656	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	3276139	23729656	39295864	310	40836											
ACSS1	84532	broad.mit.edu	37	chr20	25011402	25011402	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccacctcctcaccatcattGatcctcccagccaaggactc	9	8	4	20	0	2	1	2	1	0	0	6	2	5	2	7	1	1	0	7	1	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr20:25011402G>A	uc002wub.2	-	3	1502	c.624C>T	c.(622-624)ATC>ATT	p.I208I	ACSS1_uc002wuc.2_Silent_p.I208I|ACSS1_uc010gdc.2_Silent_p.I208I|ACSS1_uc002wua.2_Silent_p.I125I	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	208					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CACCATCATTGATCCTCCCAG	0.592													24	43					0	0	0	0	A	25011402	A	A	25011402	2	1	221	1	0	0	0	0	0	0	0	1	188	1280	45	2		2	ACSS1	20	25011402	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1281746	25011402	38014118	311	40837											
C20orf152	140894	broad.mit.edu	37	chr20	34575417	34575417	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgggcagctgatctcaaaaGattttggagagtcacccttc	11	11	10	9	0	2	3	2	1	1	2	4	4	2	3	1	2	1	2	1	2	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr20:34575417G>C	uc002xes.1	+	7	973	c.817G>C	c.(817-819)GAT>CAT	p.D273H	C20orf152_uc002xer.1_Missense_Mutation_p.D273H|C20orf152_uc010gfp.1_Intron			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	273											0	Breast(12;0.00631)					GATCTCAAAAGATTTTGGAGA	0.493													10	27					0	0	0	0	C	34575417	C	C	34575417	3	2	221	1	0	0	0	0	1	0	0	0	2102	942	33	2	843	2	C20orf152	20	34575417	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	9564015	34575417	28450103	312	40838											
RALGAPB	57148	broad.mit.edu	37	chr20	37174953	37174953	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccttgtagtcttgtgaatGagaccactttgattaaatac	11	15	7	8	0	1	3	0	3	1	1	2	4	2	3	2	0	1	1	2	0	5	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr20:37174953G>C	uc002xiw.2	+	19	3039	c.2782G>C	c.(2782-2784)GAG>CAG	p.E928Q	RALGAPB_uc002xix.2_Missense_Mutation_p.E924Q|RALGAPB_uc002xiy.1_Missense_Mutation_p.E928Q|RALGAPB_uc002xiz.2_Missense_Mutation_p.E706Q|RALGAPB_uc002xja.1_Missense_Mutation_p.E655Q	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	928					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TCTTGTGAATGAGACCACTTT	0.438													26	74					0	0	0	0	C	37174953	C	C	37174953	3	2	221	1	0	0	0	0	1	0	0	0	13080	1291	45	2	2852	2	RALGAPB	20	37174953	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	2599536	37174953	25850567	313	40839											
ZNF335	63925	broad.mit.edu	37	chr20	44578159	44578159	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcagggaccacaacatattCctgggggagcaggtgctgga	10	8	14	9	0	1	0	1	0	0	0	2	3	2	3	2	5	3	2	2	5	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr20:44578159C>T	uc002xqw.2	-	25	3841	c.3718G>A	c.(3718-3720)GAA>AAA	p.E1240K	ZNF335_uc002xqv.2_Missense_Mutation_p.E352K|ZNF335_uc010zxk.1_Missense_Mutation_p.E1085K	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1240	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				ACAACATATTCCTGGGGGAGC	0.617													10	26					0	0	0	0	T	44578159	T	T	44578159	3	4	221	1	0	0	0	0	1	0	0	0	17919	864	30	2	326	2	ZNF335	20	44578159	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	7403206	44578159	18447361	314	40840											
ELMO2	63916	broad.mit.edu	37	chr20	45000282	45000282	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagagccggttcaggcgctgCtgcttgatcagctcaaggat	8	9	13	11	2	3	2	3	1	0	1	3	3	3	3	1	3	4	5	1	3	1	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr20:45000282C>G	uc002xrt.1	-	18	1839	c.1629G>C	c.(1627-1629)CAG>CAC	p.Q543H	ELMO2_uc010zxq.1_Missense_Mutation_p.Q275H|ELMO2_uc002xrs.1_Missense_Mutation_p.Q290H|ELMO2_uc002xru.1_Missense_Mutation_p.Q543H|ELMO2_uc010zxr.1_Missense_Mutation_p.Q555H|ELMO2_uc010zxs.1_Missense_Mutation_p.Q360H|ELMO2_uc002xrv.1_Missense_Mutation_p.Q262H	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	543					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TCAGGCGCTGCTGCTTGATCA	0.612													12	32					0	0	0	0	G	45000282	G	G	45000282	3	3	221	1	0	0	0	0	1	0	0	0	5090	796	28	4	553	4	ELMO2	20	45000282	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	422123	45000282	18025238	315	40841											
PPP1R3D	5509	broad.mit.edu	37	chr20	58514571	58514571	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggctgctgcagcacaggtccGagttgattgcgagccgcgac	7	7	15	12	4	0	1	0	1	0	0	1	4	1	1	2	2	5	5	2	2	0	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr20:58514571G>C	uc002ybb.2	-	1	782	c.416C>G	c.(415-417)TCG>TGG	p.S139W	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	139					glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			GCACAGGTCCGAGTTGATTGC	0.682													13	29					0	0	0	0	C	58514571	C	C	58514571	3	2	221	1	0	0	0	0	1	0	0	0	12434	1059	37	3	487	3	PPP1R3D	20	58514571	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	13514289	58514571	4510949	316	40842											
DIDO1	11083	broad.mit.edu	37	chr20	61527745	61527745	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtcatcgctgtcattgactCtgaacagaataaaaaaaagg	17	9	8	7	1	3	3	2	2	1	1	4	3	3	3	0	1	1	1	0	1	6	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr20:61527745C>G	uc002ydr.1	-	8	2319	c.2055_splice	c.e8-1	p.R685_splice	DIDO1_uc002yds.1_Splice_Site_p.R685_splice|DIDO1_uc002ydt.1_Splice_Site_p.R685_splice|DIDO1_uc002ydu.1_Splice_Site_p.R685_splice	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c						apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GTCATTGACTCTGAACAGAAT	0.363													11	33					0	0	0	0	G	61527745	G	G	61527745	5	3	221	1	0	0	0	0	0	0	1	0	4544	927	32	2	4733	2	DIDO1	20	61527745	Splice_Site	SNP	C	TCGA-CV-7099-01A-41D-2012-08	3013174	61527745	1497775	317	40843											
KRTAP11-1	337880	broad.mit.edu	37	chr21	32253855	32253855	+	Translation_Start_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggacatgatgtcagacaGagggctgcaggtagcttgct	11	8	15	7	0	1	3	1	1	0	2	1	5	1	4	0	3	3	5	0	3	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr21:32253855G>T	uc002yov.2	-	1	20	c.-11C>A	c.(-13--9)CTCTG>CTATG			NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1							keratin filament	structural molecule activity			pancreas(1)	1						ATGTCAGACAGAGGGCTGCAG	0.517													26	70					4.43304e-23	6.53411e-23	1	0	T	32253855	T	T	32253855	1	4	221	1	0	0	0	0	0	0	0	0	8556	957	33	2		2	KRTAP11-1	21	32253855	Translation_Start_Site	SNP	G	TCGA-CV-7099-01A-41D-2012-08		32253855	15876040	318	40844											
DSCAM	1826	broad.mit.edu	37	chr21	41496216	41496216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacaaagaccatggaggctGaggccgccgctgccttcaca	11	5	11	14	2	1	2	1	1	0	1	1	3	1	3	4	3	1	2	4	3	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr21:41496216G>A	uc002yyq.1	-	20	4054	c.3602C>T	c.(3601-3603)TCA>TTA	p.S1201L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1201	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CATGGAGGCTGAGGCCGCCGC	0.592													36	89					0	0	0	0	A	41496216	A	A	41496216	3	1	221	1	0	0	0	0	1	0	0	0	4790	1294	45	2	2492	2	DSCAM	21	41496216	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	9242361	41496216	6633679	319	40845											
KRTAP10-10	353333	broad.mit.edu	37	chr21	46057496	46057496	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtccagcccctgctgccaGacggcctgtgagcccagcgc	5	6	13	17	2	0	2	0	1	0	1	1	2	1	2	6	1	5	1	6	1	0	0			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr21:46057496G>A	uc002zfq.2	+	1	224	c.162G>A	c.(160-162)CAG>CAA	p.Q54Q	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	54	3.|15 X 5 AA repeats of C-C-X(3).					keratin filament					0						CCTGCTGCCAGACGGCCTGTG	0.657													32	70					0	0	0	0	A	46057496	A	A	46057496	2	1	221	1	0	0	0	0	0	0	0	1	8545	933	33	2		2	KRTAP10-10	21	46057496	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4561280	46057496	2072399	320	40846											
TXNRD2	10587	broad.mit.edu	37	chr22	19864723	19864723	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatgtgggatggatacccaCggtccgcatcacctgcgcat	8	8	12	13	3	1	0	1	0	0	0	2	2	2	2	3	3	2	3	3	3	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr22:19864723C>T	uc011ahc.1	-	17	1513	c.1480G>A	c.(1480-1482)GTG>ATG	p.V494M	TXNRD2_uc002zql.1_Missense_Mutation_p.V248M|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Missense_Mutation_p.V493M|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_Missense_Mutation_p.V144M	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	494					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					TGGATACCCACGGTCCGCATC	0.657													8	24					0	0	0	0	T	19864723	T	T	19864723	3	4	221	1	0	0	0	0	1	0	0	0	16876	536	19	1	98	1	TXNRD2	22	19864723	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08		19864723	31439843	321	40847											
LRP5L	91355	broad.mit.edu	37	chr22	25755871	25755871	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcttgtgggaggtgctgttGaggcacgtcacctcgatgtg	6	12	15	8	2	2	1	1	1	1	0	3	3	2	2	1	3	1	3	1	3	0	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr22:25755871G>C	uc003abs.2	-	1	2654	c.189C>G	c.(187-189)CTC>CTG	p.L63L	LRP5L_uc011ajz.1_Silent_p.L63L|LRP5L_uc010guw.1_Silent_p.L63L	NM_182492	NP_872298	A4QPB2	LRP5L_HUMAN	low density lipoprotein receptor-related protein	63	LDL-receptor class B 2.										0						AGGTGCTGTTGAGGCACGTCA	0.597													18	80					0	0	0	0	C	25755871	C	C	25755871	2	2	221	1	0	0	0	0	0	0	0	1	9011	1277	45	2		2	LRP5L	22	25755871	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	5891148	25755871	25548695	322	40848											
TRIOBP	11078	broad.mit.edu	37	chr22	38168710	38168710	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcagctgaaggagcacctgCgtcttgccatggccgccctc	7	7	12	15	2	1	1	0	1	1	0	2	2	1	2	4	2	5	3	4	2	1	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr22:38168710C>T	uc003atr.2	+	23	7310	c.7039C>T	c.(7039-7041)CGT>TGT	p.R2347C	TRIOBP_uc003atu.2_Missense_Mutation_p.R2175C|TRIOBP_uc003atw.2_Missense_Mutation_p.R634C|TRIOBP_uc003atx.1_3'UTR|TRIOBP_uc010gxh.2_Missense_Mutation_p.R235C	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	2347	Potential.				actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GGAGCACCTGCGTCTTGCCAT	0.627													7	141					0	0	0	0	T	38168710	T	T	38168710	3	4	221	1	0	0	0	0	1	0	0	0	16620	768	27	1	7423	1	TRIOBP	22	38168710	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	12412839	38168710	13135856	323	40849											
PARVG	64098	broad.mit.edu	37	chr22	44583758	44583758	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcctacaccacctattcCgtaagtggctgtttctgggg	7	13	9	12	1	2	0	1	0	1	0	4	0	4	0	4	3	1	3	4	3	3	5	rs147016590		TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr22:44583758C>T	uc011aqe.1	+	5	671	c.247C>T	c.(247-249)CAG>TAG	p.Q83*	PARVG_uc010gzo.2_3'UTR|PARVG_uc010gzp.2_RNA|PARVG_uc003bep.2_Nonsense_Mutation_p.Q83*|PARVG_uc010gzr.1_RNA|PARVG_uc011aqf.1_Nonsense_Mutation_p.Q83*|PARVG_uc003beq.2_RNA|PARVG_uc003ber.2_RNA	NM_001137605	NP_001131077	Q9HBI0	PARVG_HUMAN	parvin, gamma	83	CH 1.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding				0		Ovarian(80;0.024)|all_neural(38;0.0299)				CCACCTATTCCGTAAGTGGCT	0.562													13	34					0	0	0	0	T	44583758	T	T	44583758	4	4	221	1	0	0	0	0	0	1	0	0	11524	666	23	1	257	1	PARVG	22	44583758	Nonsense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	6415048	44583758	6720808	324	40850											
SBF1	6305	broad.mit.edu	37	chr22	50906317	50906317	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaaggtcggtggattcctCtcgggacacagctgccaccc	9	7	12	13	2	1	1	0	0	1	1	4	3	2	3	3	4	2	1	3	4	2	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chr22:50906317C>G	uc003blh.2	-	3	372	c.177G>C	c.(175-177)GAG>GAC	p.E59D	SBF1_uc011arx.1_5'Flank|SBF1_uc003bli.2_Missense_Mutation_p.E59D	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	59	UDENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GTGGATTCCTCTCGGGACACA	0.632													20	34					0	0	0	0	G	50906317	G	G	50906317	3	3	221	1	0	0	0	0	1	0	0	0	13923	912	32	2	5660	2	SBF1	22	50906317	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	6322559	50906317	398249	325	40851											
SYAP1	94056	broad.mit.edu	37	chrX	16774794	16774794	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcacttcttagaggcagtaCggcccaaaacgccacccgtt	10	8	8	15	3	2	1	1	0	1	1	2	1	2	1	3	2	2	3	3	2	4	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:16774794C>T	uc004cxp.2	+	7	826	c.733C>T	c.(733-735)CGG>TGG	p.R245W	SYAP1_uc004cxo.2_Missense_Mutation_p.R245W|SYAP1_uc011miv.1_Missense_Mutation_p.R211W	NM_032796	NP_116185	Q96A49	SYAP1_HUMAN	SYAP1 protein	245										skin(1)	1	Hepatocellular(33;0.0997)					AGAGGCAGTACGGCCCAAAAC	0.343													12	33					0	0	0	0	T	16774794	T	T	16774794	3	4	221	1	0	0	0	0	1	0	0	0	15492	527	19	1	759	1	SYAP1	23	16774794	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08		16774794	138495766	326	40852											
MED14	9282	broad.mit.edu	37	chrX	40534538	40534538	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catatctcctcctataggagAagggggattatcgtcctcat	10	12	9	10	1	2	1	1	0	1	1	6	3	4	2	3	3	0	0	3	3	5	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:40534538A>T	uc004dex.3	-	22	3096	c.2956T>A	c.(2956-2958)TCT>ACT	p.S986T		NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	986					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						CCTATAGGAGAAGGGGGATTA	0.423													14	39					0	0	0	0	T	40534538	T	T	40534538	3	4	221	1	0	0	0	0	1	0	0	0	9485	246	9	5	1448	5	MED14	23	40534538	Missense_Mutation	SNP	A	TCGA-CV-7099-01A-41D-2012-08	23759744	40534538	114736022	327	40853											
CACNA1F	778	broad.mit.edu	37	chrX	49067781	49067781	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgtgaggaaatggttctcaCcaggaaggcacagagcatga	13	8	13	7	0	1	3	1	2	1	1	2	5	1	5	1	4	1	3	1	4	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:49067781C>A	uc004dnb.2	-	36	4355	c.4293_splice	c.e36+1	p.L1431_splice	CACNA1F_uc010nip.2_Splice_Site_p.L1420_splice	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,						axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	ATGGTTCTCACCAGGAAGGCA	0.552													9	31					0.000442599	0.000617023	1	0	A	49067781	A	A	49067781	5	1	221	1	0	0	0	0	0	0	1	0	2555	521	18	4	1691	4	CACNA1F	23	49067781	Splice_Site	SNP	C	TCGA-CV-7099-01A-41D-2012-08	8533243	49067781	106202779	328	40854											
AKAP4	8852	broad.mit.edu	37	chrX	49958650	49958650	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcttttaccttccaacttCtccttgatttccttatgggc	5	19	5	12	0	1	1	0	1	1	0	4	1	3	1	4	1	3	1	4	1	3	8			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:49958650C>T	uc004dow.1	-	5	838	c.714G>A	c.(712-714)GAG>GAA	p.E238E	AKAP4_uc004dov.1_Intron|AKAP4_uc010njp.1_Silent_p.E60E|AKAP4_uc004dou.1_Silent_p.E229E	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	238					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					CTTCCAACTTCTCCTTGATTT	0.448													30	90					0	0	0	0	T	49958650	T	T	49958650	2	4	221	1	0	0	0	0	0	0	0	1	453	912	32	2		2	AKAP4	23	49958650	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	890869	49958650	105311910	329	40855											
DGAT2L6	347516	broad.mit.edu	37	chrX	69424816	69424816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcatagttggggaaccccttCcaattcccaggattaagagg	11	10	10	10	0	1	1	1	0	0	1	3	3	3	3	4	4	1	1	4	4	4	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:69424816C>T	uc004dxx.1	+	7	971	c.874C>T	c.(874-876)CCA>TCA	p.P292S		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	292					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						GGAACCCCTTCCAATTCCCAG	0.463													10	26					0	0	0	0	T	69424816	T	T	69424816	3	4	221	1	0	0	0	0	1	0	0	0	4481	855	30	2	900	2	DGAT2L6	23	69424816	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	19466166	69424816	85845744	330	40856											
P2RY10	27334	broad.mit.edu	37	chrX	78216842	78216842	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtaaaggaaaccatcattagCagttgtcccgttgtccgaat	12	11	9	9	2	1	0	1	0	0	0	3	2	3	1	3	1	2	4	3	1	5	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:78216842C>A	uc004ede.2	+	4	1194	c.825C>A	c.(823-825)AGC>AGA	p.S275R	P2RY10_uc004edf.2_Missense_Mutation_p.S275R	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	275	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CCATCATTAGCAGTTGTCCCG	0.423													80	161					3.37217e-29	4.98341e-29	1	0	A	78216842	A	A	78216842	3	1	221	1	0	0	0	0	1	0	0	0	11401	709	25	4	827	4	P2RY10	23	78216842	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	8792026	78216842	77053718	331	40857											
BRWD3	254065	broad.mit.edu	37	chrX	79975138	79975138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctgcccaattacctgttCtactacctcaccatcacctt	8	14	3	16	0	3	0	2	0	1	0	3	0	3	0	5	0	5	2	5	0	4	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:79975138C>T	uc004edt.2	-	18	2157	c.1894G>A	c.(1894-1896)GAA>AAA	p.E632K	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.E228K|BRWD3_uc004edp.2_Missense_Mutation_p.E461K|BRWD3_uc004edq.2_Missense_Mutation_p.E228K|BRWD3_uc010nmj.1_Missense_Mutation_p.E228K|BRWD3_uc004edr.2_Missense_Mutation_p.E302K|BRWD3_uc004eds.2_Missense_Mutation_p.E228K|BRWD3_uc004edu.2_Missense_Mutation_p.E302K|BRWD3_uc004edv.2_Missense_Mutation_p.E228K|BRWD3_uc004edw.2_Missense_Mutation_p.E228K|BRWD3_uc004edx.2_Missense_Mutation_p.E228K|BRWD3_uc004edy.2_Missense_Mutation_p.E228K|BRWD3_uc004edz.2_Missense_Mutation_p.E302K|BRWD3_uc004eea.2_Missense_Mutation_p.E302K|BRWD3_uc004eeb.2_Missense_Mutation_p.E228K	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	632										ovary(4)	4						ATTACCTGTTCTACTACCTCA	0.358													30	86					0	0	0	0	T	79975138	T	T	79975138	3	4	221	1	0	0	0	0	1	0	0	0	1531	922	32	2	3610	2	BRWD3	23	79975138	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1758296	79975138	75295422	332	40858											
NAP1L3	4675	broad.mit.edu	37	chrX	92927775	92927775	+	Frame_Shift_Del	DEL	C	-	-																															actaggggtgttatcctgcaCctcctcatcactgctgaact																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:92927775delC	uc004efq.2	-	1	834	c.529delG	c.(529-531)GTGfs	p.V177fs	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	177	Glu-rich.				nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						TTATCCTGCACCTCCTCATCA	0.453													---	---	---								-	92927775	-	-	92927775	7	5	221	1	0	1	0	1	0	0	0	0	10211	507	18	0	995	0	NAP1L3	23	92927775	Frame_Shift_Del	DEL	C	TCGA-CV-7099-01A-41D-2012-08	12952637	92927775	62342785	333	40859											
DIAPH2	1730	broad.mit.edu	37	chrX	96204003	96204003	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagagatgagaaaatcaaaGaacttgaagcagaaatccag	22	5	9	5	0	1	5	1	2	0	4	2	7	2	5	1	0	2	1	1	0	7	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:96204003G>A	uc004efu.3	+	15	1975	c.1579G>A	c.(1579-1581)GAA>AAA	p.E527K	DIAPH2_uc004eft.3_Missense_Mutation_p.E527K	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	527	Potential.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						GAAAATCAAAGAACTTGAAGC	0.373													11	30					0	0	0	0	A	96204003	A	A	96204003	3	1	221	1	0	0	0	0	1	0	0	0	4541	943	33	2	1637	2	DIAPH2	23	96204003	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	3276228	96204003	59066557	334	40860											
XKRX	402415	broad.mit.edu	37	chrX	100169570	100169570	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtaacactttcactccaaaGaacttaaaaaccaagaccat	19	8	3	11	0	1	2	1	0	0	2	2	2	2	2	3	0	3	1	3	0	7	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:100169570G>C	uc004egn.2	-	3	1712	c.1107C>G	c.(1105-1107)TTC>TTG	p.F369L	XKRX_uc011mre.1_Missense_Mutation_p.F165L	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	369	Helical; (Potential).					integral to membrane|plasma membrane				breast(1)	1						TCACTCCAAAGAACTTAAAAA	0.428													51	114					0	0	0	0	C	100169570	C	C	100169570	3	2	221	1	0	0	0	0	1	0	0	0	17507	933	33	2	246	2	XKRX	23	100169570	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	3965567	100169570	55100990	335	40861											
COL4A5	1287	broad.mit.edu	37	chrX	107925060	107925060	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gatgctggtcctccaggaatCcctggccagcctgggctaaa	8	8	12	13	0	0	0	0	0	0	0	3	2	3	1	5	4	2	2	5	4	3	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:107925060C>G	uc004enz.1	+	46	4360	c.4158C>G	c.(4156-4158)ATC>ATG	p.I1386M	COL4A5_uc011mso.1_Missense_Mutation_p.I1383M|COL4A5_uc011msp.1_Missense_Mutation_p.I62M	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1380	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						CTCCAGGAATCCCTGGCCAGC	0.443									Alport_syndrome_with_Diffuse_Leiomyomatosis				13	58					0	0	0	0	G	107925060	G	G	107925060	3	3	221	1	0	0	0	0	1	0	0	0	3709	845	30	2	4329	2	COL4A5	23	107925060	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	7755490	107925060	47345500	336	40862											
DOCK11	139818	broad.mit.edu	37	chrX	117707777	117707778	+	Frame_Shift_Ins	INS	-	T	T																															ttcattcccaggttgagcccINSttttttatcaatcttgcctt																										TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:117707777_117707778insT	uc004eqp.2	+	12	1248_1249	c.1185_1186insT	c.(1183-1188)CCCTTTfs	p.P395fs	DOCK11_uc004eqq.2_Frame_Shift_Ins_p.P161fs	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	395_396					blood coagulation	cytosol	GTP binding			ovary(3)	3						AGGTTGAGCCCTTTTTTATCAA	0.411													---	---	---								T	117707778	T	T	117707777	7	5	221	1	0	1	1	0	0	0	0	0	4708	668	24	0	1231	0	DOCK11	23	117707777	Frame_Shift_Ins	INS	-	TCGA-CV-7099-01A-41D-2012-08	9782717	117707777	37562783	337	40863											
SLC25A43	203427	broad.mit.edu	37	chrX	118586986	118586986	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacgagaattaaagaagttCttcaaaacgagaaaaccgaa	20	8	7	6	3	2	3	1	0	1	3	2	6	2	3	1	0	3	1	1	0	10	4			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:118586986C>A	uc004erd.2	+	5	1328	c.984C>A	c.(982-984)TTC>TTA	p.F328L	SLC25A43_uc011mtt.1_3'UTR	NM_145305	NP_660348	Q8WUT9	S2543_HUMAN	mitochondrial solute carrier protein	328					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			skin(1)	1						TAAAGAAGTTCTTCAAAACGA	0.388													36	82					1.06647e-15	1.55975e-15	1	0	A	118586986	A	A	118586986	3	1	221	1	0	0	0	0	1	0	0	0	14572	912	32	2	1002	2	SLC25A43	23	118586986	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	879209	118586986	36683574	338	40864											
SEPT6	23157	broad.mit.edu	37	chrX	118763373	118763373	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccgccgtctttctttgcttGaaagcattcacttcatcatc	7	15	6	13	2	5	1	3	1	2	0	6	1	5	1	2	0	2	2	2	0	1	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:118763373G>A	uc004erv.2	-	9	1453	c.1188C>T	c.(1186-1188)TTC>TTT	p.F396F	SEPT6_uc010nqk.2_RNA|SEPT6_uc004ers.2_Silent_p.F396F|SEPT6_uc004ert.2_Silent_p.F396F|SEPT6_uc004eru.2_Silent_p.F396F|SEPT6_uc004erw.2_Silent_p.F338F|SEPT6_uc011mtv.1_Silent_p.F338F|SEPT6_uc011mtw.1_Silent_p.F426F	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	396	Potential.				cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4						TTCTTTGCTTGAAAGCATTCA	0.493													67	101					0	0	0	0	A	118763373	A	A	118763373	2	1	221	1	0	0	0	0	0	0	0	1	14133	1281	45	2		2	SEPT6	23	118763373	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	176387	118763373	36507187	339	40865											
ELF4	2000	broad.mit.edu	37	chrX	129203540	129203540	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtggggctgctgtggcttCgctgctctcatcctcatctt	3	14	12	12	1	3	0	2	0	2	0	6	0	4	0	1	4	2	5	1	4	0	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:129203540C>T	uc004evd.3	-	8	1307	c.922G>A	c.(922-924)GAA>AAA	p.E308K	ELF4_uc004eve.3_Missense_Mutation_p.E308K	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	308					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCTGTGGCTTCGCTGCTCTCA	0.602			T	ERG	AML								11	123					0	0	0	0	T	129203540	T	T	129203540	3	4	221	1	0	0	0	0	1	0	0	0	5080	893	31	1	1077	1	ELF4	23	129203540	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	10440167	129203540	26067020	340	40866											
SAGE1	55511	broad.mit.edu	37	chrX	134989482	134989482	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgttttccagattccaccgtCcctcacaatgtctgtgaaga	9	13	7	12	1	2	3	1	1	1	2	5	3	5	3	4	0	0	1	4	0	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:134989482C>T	uc004ezh.2	+	9	1055	c.888C>T	c.(886-888)GTC>GTT	p.V296V	SAGE1_uc010nry.1_Silent_p.V265V|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	296										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					ATTCCACCGTCCCTCACAATG	0.418													5	82					0	0	0	0	T	134989482	T	T	134989482	2	4	221	1	0	0	0	0	0	0	0	1	13874	842	30	2		2	SAGE1	23	134989482	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	5785942	134989482	20281078	341	40867											
SAGE1	55511	broad.mit.edu	37	chrX	134991057	134991057	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagtgttcgtgaagagaaGatggaaagtggcaaacccca	15	6	12	8	1	0	3	0	1	0	2	1	5	0	4	2	2	1	2	2	2	4	1			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:134991057G>A	uc004ezh.2	+	13	1643	c.1476G>A	c.(1474-1476)AAG>AAA	p.K492K	SAGE1_uc010nry.1_Silent_p.K461K|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	492										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GTGAAGAGAAGATGGAAAGTG	0.468													32	61					0	0	0	0	A	134991057	A	A	134991057	2	1	221	1	0	0	0	0	0	0	0	1	13874	933	33	2		2	SAGE1	23	134991057	Silent	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1575	134991057	20279503	342	40868											
ZIC3	7547	broad.mit.edu	37	chrX	136652129	136652129	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactccacccgctatagcttCtgcaaacagtaaagatacca	14	8	5	14	1	1	1	0	0	1	1	2	1	2	1	3	0	4	4	3	0	6	5			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:136652129C>A	uc004fak.2	+	3	1809	c.1304C>A	c.(1303-1305)TCT>TAT	p.S435Y		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	435					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GCTATAGCTTCTGCAAACAGT	0.438													82	146					3.37217e-29	4.98341e-29	1	0	A	136652129	A	A	136652129	3	1	221	1	0	0	0	0	1	0	0	0	17747	913	32	2	1314	2	ZIC3	23	136652129	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1661072	136652129	18618431	343	40869											
F9	2158	broad.mit.edu	37	chrX	138619217	138619217	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattctgaatcggccaaagaGgtataattcaggtaaattgg	15	11	10	5	1	2	2	1	1	1	1	3	2	2	2	1	4	0	2	1	4	7	6			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:138619217G>A	uc004fas.1	+	2	166	c.137G>A	c.(136-138)AGG>AAG	p.R46K	F9_uc004fat.1_Missense_Mutation_p.R46K	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	46			R -> T (in HEMB; severe).|R -> S (in HEMB; severe; Cambridge).		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	CGGCCAAAGAGGTATAATTCA	0.323													8	173					0	0	0	0	A	138619217	A	A	138619217	3	1	221	1	0	0	0	0	1	0	0	0	5379	1000	35	4	143	4	F9	23	138619217	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	1967088	138619217	16651343	344	40870											
SPANXN2	494119	broad.mit.edu	37	chrX	142795394	142795394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcttcgtcctcctgtgaaGatccttcagctgagtctagg	6	13	11	11	1	3	3	1	2	2	1	7	3	6	3	3	2	1	1	3	2	2	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:142795394G>A	uc004fbz.2	-	2	1038	c.284C>T	c.(283-285)TCT>TTT	p.S95F		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	95										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCTGTGAAGATCCTTCAGC	0.502													164	354					0	0	0	0	A	142795394	A	A	142795394	3	1	221	1	0	0	0	0	1	0	0	0	15057	942	33	2	262	2	SPANXN2	23	142795394	Missense_Mutation	SNP	G	TCGA-CV-7099-01A-41D-2012-08	4176177	142795394	12475166	345	40871											
GABRE	2564	broad.mit.edu	37	chrX	151123391	151123391	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagaggctgcggggaccctCagggctacctgggctagggg	6	5	19	11	1	1	1	1	0	0	1	1	2	1	2	2	7	2	4	2	7	2	2			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:151123391C>G	uc004ffi.2	-	9	1357	c.1303G>C	c.(1303-1305)GAG>CAG	p.E435Q	GABRE_uc011myd.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	435	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CGGGGACCCTCAGGGCTACCT	0.592													8	19					0	0	0	0	G	151123391	G	G	151123391	3	3	221	1	0	0	0	0	1	0	0	0	6204	835	29	2	221	2	GABRE	23	151123391	Missense_Mutation	SNP	C	TCGA-CV-7099-01A-41D-2012-08	8327997	151123391	4147169	346	40872											
ATP2B3	492	broad.mit.edu	37	chrX	152845456	152845456	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atccgggtggtgaaagcgttCcgtagctcgctctatgaagg	8	10	14	9	4	1	2	0	2	1	0	4	2	3	2	2	3	2	4	2	3	4	3			TCGA-CV-7099-01A-41D-2012-08	TCGA-CV-7099-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	12a04e68-c814-4a18-a469-d7edc76e362d	2fa45425-c966-45cb-9f21-e4e135882e5a	g.chrX:152845456C>T	uc004fht.1	+	20	3489	c.3363C>T	c.(3361-3363)TTC>TTT	p.F1121F	ATP2B3_uc004fhs.1_Missense_Mutation_p.P1173S|ATP2B3_uc010nuf.1_Silent_p.F258F|ATP2B3_uc004fhu.1_Silent_p.F73F	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	1121	Calmodulin-binding subdomain B (By similarity).|Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGAAAGCGTTCCGTAGCTCGC	0.463													51	70					0	0	0	0	T	152845456	T	T	152845456	2	4	221	1	0	0	0	0	0	0	0	1	1143	855	30	2		2	ATP2B3	23	152845456	Silent	SNP	C	TCGA-CV-7099-01A-41D-2012-08	1722065	152845456	2425104	347	40873											
UBR4	23352	broad.mit.edu	37	chr1	19451143	19451143	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcctcagtaccatttctgtTagaagctgagtataggcctc	10	12	9	10	0	2	2	1	1	1	1	3	2	2	2	3	1	3	4	3	1	5	5			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr1:19451143T>G	uc001bbi.2	-	65	9484	c.9480A>C	c.(9478-9480)CTA>CTC	p.L3160L	UBR4_uc001bbk.1_Silent_p.L807L	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3160					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCATTTCTGTTAGAAGCTGAG	0.423													14	44					0	0	0	0	G	19451143	G	G	19451143	2	3	222	1	0	0	0	0	0	0	0	1	16972	1741	61	5		5	UBR4	1	19451143	Silent	SNP	T	TCGA-CV-7100-01A-11D-2012-08		19451143	229799478	1	40874											
GPBP1L1	60313	broad.mit.edu	37	chr1	46099783	46099784	+	Frame_Shift_Ins	INS	-	A	A																															tcacctctttgggagaactcINSagagctgcaccactagccag																										TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr1:46099783_46099784insA	uc001coq.2	-	9	2230_2231	c.869_870insT	c.(868-870)CTGfs	p.L290fs	GPBP1L1_uc001coo.2_Frame_Shift_Ins_p.L34fs	NM_021639	NP_067652	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGGGAGAACTCAGAGCTGCACC	0.465													---	---	---								A	46099784	A	A	46099783	7	5	222	1	0	1	1	0	0	0	0	0	6634	813	29	0	574	0	GPBP1L1	1	46099783	Frame_Shift_Ins	INS	-	TCGA-CV-7100-01A-11D-2012-08	26648640	46099783	203150838	2	40875											
ALK	238	broad.mit.edu	37	chr2	29451771	29451772	+	Frame_Shift_Del	DEL	CA	-	-																															tatatatcctccgcctcctcCacctgaggagcacccccctc																										TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr2:29451771_29451772delCA	uc002rmy.2	-	16	3700_3701	c.2793_2794delTG	c.(2791-2796)GGTGGAfs	p.G931fs		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	931_932	Gly-rich.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCGCCTCCTCCACCTGAGGAGC	0.545			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				---	---	---								-	29451772	-	-	29451771	7	5	222	1	0	1	0	1	0	0	0	0	525	603	21	0	2124	0	ALK	2	29451771	Frame_Shift_Del	DEL	CA	TCGA-CV-7100-01A-11D-2012-08		29451771	213747602	3	40876											
C3orf1	51300	broad.mit.edu	37	chr3	119219666	119219667	+	Frame_Shift_Ins	INS	-	AG	AG																															taaacaacaatacattgagcINSagagccaggcagaaatttat																										TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:119219666_119219667insAG	uc003ecn.2	+	2	532_533	c.319_320insAG	c.(319-321)CAGfs	p.Q107fs	C3orf1_uc003eco.2_RNA|C3orf1_uc003ecp.2_RNA	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300	107						integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		ATACATTGAGCAGAGCCAGGCA	0.421													---	---	---								AG	119219667	AG	AG	119219666	7	5	222	1	0	1	1	0	0	0	0	0	2216	711	25	0	325	0	C3orf1	3	119219666	Frame_Shift_Ins	INS	-	TCGA-CV-7100-01A-11D-2012-08		119219666	78802764	4	40877											
PRR23A	729627	broad.mit.edu	37	chr3	138724434	138724434	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggagaggtgagctggggAcaggctccagaaggcggaat	10	6	19	6	1	0	3	0	1	0	2	1	6	1	5	1	7	1	3	1	7	2	1			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:138724434A>G	uc011bms.1	-	1	677	c.677T>C	c.(676-678)GTC>GCC	p.V226A		NM_001134659	NP_001128131	A6NEV1	PR23A_HUMAN	proline rich 23A	226	Pro-rich.										0						TGAGCTGGGGACAGGCTCCAG	0.682													6	17					0	0	0	0	G	138724434	G	G	138724434	3	3	222	1	0	0	0	0	1	0	0	0	12656	275	10	5	127	5	PRR23A	3	138724434	Missense_Mutation	SNP	A	TCGA-CV-7100-01A-11D-2012-08	19504768	138724434	59297996	5	40878											
KPNA4	3840	broad.mit.edu	37	chr3	160239585	160239585	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acctgaactttaacttcctgGtggctgagcagaggaaccaa	12	9	10	10	0	0	3	0	2	0	1	1	4	1	4	3	3	4	2	3	3	4	3			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:160239585G>A	uc003fdn.2	-	11	1191	c.885C>T	c.(883-885)CAC>CAT	p.H295H		NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4	295	ARM 6.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			TAACTTCCTGGTGGCTGAGCA	0.388													53	79					0	0	0	0	A	160239585	A	A	160239585	2	1	222	1	0	0	0	0	0	0	0	1	8471	1252	44	4		4	KPNA4	3	160239585	Silent	SNP	G	TCGA-CV-7100-01A-11D-2012-08	21515151	160239585	37782845	6	40879											
NAALADL2	254827	broad.mit.edu	37	chr3	174974236	174974236	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagttatggaatggcagatGatttaaaaaggattaggaaa	17	11	12	1	0	0	3	0	2	0	1	0	6	0	6	0	4	0	2	0	4	7	4			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:174974236G>A	uc003fit.2	+	4	943	c.856G>A	c.(856-858)GAT>AAT	p.D286N	NAALADL2_uc003fiu.1_Missense_Mutation_p.D279N|NAALADL2_uc010hwy.1_Missense_Mutation_p.D108N|NAALADL2_uc010hwz.1_5'UTR	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	286	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		AATGGCAGATGATTTAAAAAG	0.363													14	78					0	0	0	0	A	174974236	A	A	174974236	3	1	222	1	0	0	0	0	1	0	0	0	10183	1290	45	2	870	2	NAALADL2	3	174974236	Missense_Mutation	SNP	G	TCGA-CV-7100-01A-11D-2012-08	14734651	174974236	23048194	7	40880											
SLC4A4	8671	broad.mit.edu	37	chr4	72319250	72319250	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taaagacataaagaggaaagCgccattttttgccagtgatt	15	11	9	6	1	0	3	0	1	0	2	0	4	0	4	2	1	2	0	2	1	5	6	rs138493429	byFrequency	TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr4:72319250C>G	uc003hfy.2	+	12	1478	c.1361C>G	c.(1360-1362)GCG>GGG	p.A454G	SLC4A4_uc010iic.2_Missense_Mutation_p.A454G|SLC4A4_uc010iib.2_Missense_Mutation_p.A454G|SLC4A4_uc003hfz.2_Missense_Mutation_p.A454G|SLC4A4_uc003hgc.3_Missense_Mutation_p.A410G|SLC4A4_uc010iid.2_Intron|SLC4A4_uc003hga.2_Missense_Mutation_p.A332G|SLC4A4_uc003hgb.3_Missense_Mutation_p.A410G	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	454	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AAGAGGAAAGCGCCATTTTTT	0.343													28	113					0	0	0	0	G	72319250	G	G	72319250	3	3	222	1	0	0	0	0	1	0	0	0	14720	768	27	3	1524	3	SLC4A4	4	72319250	Missense_Mutation	SNP	C	TCGA-CV-7100-01A-11D-2012-08		72319250	118835026	8	40881											
FSTL5	56884	broad.mit.edu	37	chr4	162307557	162307558	+	Frame_Shift_Ins	INS	-	T	T																															tgacatggtttcaagatcaaINSttttttgtagtgcagcttca																										TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr4:162307557_162307558insT	uc003iqh.2	-	16	2321_2322	c.1885_1886insA	c.(1885-1887)ATTfs	p.I629fs	FSTL5_uc003iqi.2_Frame_Shift_Ins_p.I628fs|FSTL5_uc010iqv.2_Frame_Shift_Ins_p.I619fs|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	629						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTCAAGATCAATTTTTTGTAGT	0.361													---	---	---								T	162307558	T	T	162307557	7	5	222	1	0	1	1	0	0	0	0	0	6114	101	4	0	661	0	FSTL5	4	162307557	Frame_Shift_Ins	INS	-	TCGA-CV-7100-01A-11D-2012-08	89988307	162307557	28846719	9	40882											
ACSL1	2180	broad.mit.edu	37	chr4	185684332	185684332	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcactcacctcgccctcgcCctcggcagccatgtaattca	7	10	6	18	3	3	0	3	0	0	0	6	0	3	0	4	1	1	2	4	1	1	3			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr4:185684332C>T	uc003iww.2	-	16	1804	c.1510G>A	c.(1510-1512)GGC>AGC	p.G504S	ACSL1_uc011ckm.1_Missense_Mutation_p.G333S|ACSL1_uc003iwt.1_Missense_Mutation_p.G504S|ACSL1_uc003iwu.1_Missense_Mutation_p.G504S|ACSL1_uc011ckn.1_Missense_Mutation_p.G470S|ACSL1_uc003iws.1_Missense_Mutation_p.G74S	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	504	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCGCCCTCGCCCTCGGCAGCC	0.488													10	28					0	0	0	0	T	185684332	T	T	185684332	3	4	222	1	0	0	0	0	1	0	0	0	177	623	22	4	610	4	ACSL1	4	185684332	Missense_Mutation	SNP	C	TCGA-CV-7100-01A-11D-2012-08	23376775	185684332	5469944	10	40883											
ARSI	340075	broad.mit.edu	37	chr5	149676844	149676844	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcgaagcttgcaaatcttgCattttttcttgcgacgaccc	9	14	7	11	3	2	0	0	0	2	0	3	3	2	0	1	0	4	3	1	0	2	6			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr5:149676844C>A	uc003lrv.2	-	2	2232	c.1643G>T	c.(1642-1644)TGC>TTC	p.C548F		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	548						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAAATCTTGCATTTTTTCTT	0.527													48	84					6.61955e-31	3.56195e-30	1	0	A	149676844	A	A	149676844	3	1	222	1	0	0	0	0	1	0	0	0	996	710	25	4	70	4	ARSI	5	149676844	Missense_Mutation	SNP	C	TCGA-CV-7100-01A-11D-2012-08		149676844	31238416	11	40884											
C8orf80	389643	broad.mit.edu	37	chr8	27925899	27925899	+	Frame_Shift_Del	DEL	A	-	-																															cagccccagtgcttccaaatAatgcaatgtagattgggtcc																										TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr8:27925899delA	uc003xgm.3	-	5	457	c.314delT	c.(313-315)TTAfs	p.L105fs		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	105						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		GCTTCCAAATAATGCAATGTA	0.433													---	---	---								-	27925899	-	-	27925899	7	5	222	1	0	1	0	1	0	0	0	0	2451	372	13	0	2136	0	C8orf80	8	27925899	Frame_Shift_Del	DEL	A	TCGA-CV-7100-01A-11D-2012-08		27925899	118438123	12	40885											
SLC30A8	169026	broad.mit.edu	37	chr8	118170064	118170064	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgatcatcgtttccagctgcGcagtggcggccaacattgtg	7	11	12	11	3	1	1	1	1	0	0	3	1	2	1	2	2	3	3	2	2	1	2			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr8:118170064G>A	uc003yoh.2	+	4	783	c.553G>A	c.(553-555)GCA>ACA	p.A185T	SLC30A8_uc010mcz.2_Missense_Mutation_p.A136T|SLC30A8_uc011lia.1_Missense_Mutation_p.A136T|SLC30A8_uc003yog.2_Missense_Mutation_p.A136T	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	185	Helical; (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TTCCAGCTGCGCAGTGGCGGC	0.527													37	69					0	0	0	0	A	118170064	A	A	118170064	3	1	222	1	0	0	0	0	1	0	0	0	14625	1087	38	1	567	1	SLC30A8	8	118170064	Missense_Mutation	SNP	G	TCGA-CV-7100-01A-11D-2012-08	90244165	118170064	28193958	13	40886											
ALPK3	57538	broad.mit.edu	37	chr15	85383922	85383922	+	Frame_Shift_Del	DEL	C	-	-																															ccagcccacacactccttgaCcccccagccgactaggcctt																								rs143709902	byFrequency	TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr15:85383922delC	uc002ble.2	+	5	2185	c.2018delC	c.(2017-2019)ACCfs	p.T673fs		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	673					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CACTCCTTGACCCCCCAGCCG	0.617													---	---	---								-	85383922	-	-	85383922	7	5	222	1	0	1	0	1	0	0	0	0	546	507	18	0	2036	0	ALPK3	15	85383922	Frame_Shift_Del	DEL	C	TCGA-CV-7100-01A-11D-2012-08		85383922	17147470	14	40887											
IL34	146433	broad.mit.edu	37	chr16	70693992	70693993	+	Frame_Shift_Ins	INS	-	AGCTG	AGCTG																															attgcagtatgcggccacccINSagctgtaccctccgcccccg																										TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr16:70693992_70693993insAGCTG	uc002ezh.1	+	6	1014_1015	c.631_632insAGCTG	c.(631-633)CAGfs	p.Q211fs	IL34_uc002ezi.1_Frame_Shift_Ins_p.Q210fs	NM_152456	NP_689669	Q6ZMJ4	IL34_HUMAN	interleukin 34 precursor	211					positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			central_nervous_system(1)|skin(1)	2						TGCGGCCACCCAGCTGTACCCT	0.649													---	---	---								AGCTG	70693993	AGCTG	AGCTG	70693992	7	5	222	1	0	1	1	0	0	0	0	0	7733	595	21	0	653	0	IL34	16	70693992	Frame_Shift_Ins	INS	-	TCGA-CV-7100-01A-11D-2012-08		70693992	19660761	15	40888											
LDHD	197257	broad.mit.edu	37	chr16	75146279	75146279	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactttgcctggattcatgAggccttgggggtctagcacg	6	11	14	10	1	2	1	1	1	1	0	2	2	2	2	2	4	2	2	2	4	1	4			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr16:75146279A>G	uc002fdm.2	-	11	1546	c.1499T>C	c.(1498-1500)CTC>CCC	p.L500P	LDHD_uc002fdn.2_Missense_Mutation_p.L477P	NM_153486	NP_705690	Q86WU2	LDHD_HUMAN	D-lactate dehydrogenase isoform 1 precursor	500							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding				0						TGGATTCATGAGGCCTTGGGG	0.622													3	37					0	0	0	0	G	75146279	G	G	75146279	3	3	222	1	0	0	0	0	1	0	0	0	8743	304	11	5	28	5	LDHD	16	75146279	Missense_Mutation	SNP	A	TCGA-CV-7100-01A-11D-2012-08	4452287	75146279	15208474	16	40889											
MYO1D	4642	broad.mit.edu	37	chr17	30821787	30821787	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccgcggggcgtcagttcccgGgcacgctgaggatgaagccc	6	5	16	14	5	1	2	1	2	0	0	2	3	2	3	3	4	1	3	3	4	1	1			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr17:30821787G>T	uc002hho.1	-	22	3023	c.3011C>A	c.(3010-3012)CCC>CAC	p.P1004H		NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	1004						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			TCAGTTCCCGGGCACGCTGAG	0.682													7	11					0.00198382	0.00974658	1	0	T	30821787	T	T	30821787	3	4	222	1	0	0	0	0	1	0	0	0	10124	1232	43	4	13	4	MYO1D	17	30821787	Missense_Mutation	SNP	G	TCGA-CV-7100-01A-11D-2012-08		30821787	50373423	17	40890											
PDYN	5173	broad.mit.edu	37	chr20	1961249	1961249	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggggtcctcctcagcgagaTagagtgtgccagtctccatg	7	10	13	11	1	2	2	1	0	1	2	5	3	4	2	4	2	2	0	4	2	1	1			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr20:1961249T>G	uc010gaj.2	-	3	727	c.485A>C	c.(484-486)TAT>TCT	p.Y162S	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.Y162S|PDYN_uc010zpt.1_Missense_Mutation_p.Y7S	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	162					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTCAGCGAGATAGAGTGTGCC	0.597													5	94					0	0	0	0	G	1961249	G	G	1961249	3	3	222	1	0	0	0	0	1	0	0	0	11753	1406	49	5	283	5	PDYN	20	1961249	Missense_Mutation	SNP	T	TCGA-CV-7100-01A-11D-2012-08		1961249	61064271	18	40891											
PLCB1	23236	broad.mit.edu	37	chr20	8678323	8678323	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgtatcgccaagtgctcCtgtctggttgtcgctgtgtg	5	14	13	9	2	1	1	0	0	1	1	4	1	2	1	2	1	1	4	2	1	2	2			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr20:8678323C>T	uc002wnb.2	+	11	1063	c.1060C>T	c.(1060-1062)CTG>TTG	p.L354L	PLCB1_uc010zrb.1_Silent_p.L253L|PLCB1_uc002wna.2_Silent_p.L354L|PLCB1_uc002wnc.1_Silent_p.L253L	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	354	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CCAAGTGCTCCTGTCTGGTTG	0.502													38	86					0	0	0	0	T	8678323	T	T	8678323	2	4	222	1	0	0	0	0	0	0	0	1	12082	680	24	4		4	PLCB1	20	8678323	Silent	SNP	C	TCGA-CV-7100-01A-11D-2012-08	6717074	8678323	54347197	19	40892											
EP300	2033	broad.mit.edu	37	chr22	41565529	41565529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtatacatatcttacctcGatagtgttcatttcttccgt	9	17	6	9	2	3	0	1	0	2	0	5	2	4	0	2	0	2	2	2	0	5	8			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr22:41565529G>A	uc003azl.3	+	26	4590	c.4195G>A	c.(4195-4197)GAT>AAT	p.D1399N		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1399				D->Y: Does not interact with TFAP2A and inhibits transcriptional coactivation of TFAP2A by CITED2. Does not inhibit interaction with CITED2, DNA-binding of TFAP2A or nuclear localization of TFAP2A or CITED2.	apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.D1399Y(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ATCTTACCTCGATAGTGTTCA	0.338			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				32	24					0	0	0	0	A	41565529	A	A	41565529	3	1	222	1	0	0	0	0	1	0	0	0	5172	1058	37	1	4297	1	EP300	22	41565529	Missense_Mutation	SNP	G	TCGA-CV-7100-01A-11D-2012-08		41565529	9739037	20	40893											
CLCN4	1183	broad.mit.edu	37	chrX	10201603	10201603	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatggcaaaccaggacccCgaatccatcatgtttaatta	14	9	7	11	1	1	1	1	0	0	1	2	3	2	2	4	2	1	2	4	2	4	3			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chrX:10201603C>T	uc004csy.3	+	13	2692	c.2262C>T	c.(2260-2262)CCC>CCT	p.P754P	CLCN4_uc011mid.1_Silent_p.P660P	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	754	CBS 2.|Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						ACCAGGACCCCGAATCCATCA	0.363													4	40					0	0	0	0	T	10201603	T	T	10201603	2	4	222	1	0	0	0	0	0	0	0	1	3480	639	23	1		1	CLCN4	23	10201603	Silent	SNP	C	TCGA-CV-7100-01A-11D-2012-08		10201603	145068957	21	40894											
HTR6	3362	broad.mit.edu	37	chr1	20005114	20005126	+	Frame_Shift_Del	DEL	ACGAAGCACAGCA	-	-																															ctgacagcaggcgtctagccAcgaagcacagcaggaaggcc																								rs143893286	byFrequency	TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:20005114_20005126delACGAAGCACAGCA	uc001bcl.2	+	2	1236_1248	c.769_781delACGAAGCACAGCA	c.(769-783)ACGAAGCACAGCAGGfs	p.T257fs		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	257_261	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	GCGTCTAGCCACGAAGCACAGCAGGAAGGCCCT	0.615													---	---	---								-	20005126	-	-	20005114	7	5	223	1	0	1	0	1	0	0	0	0	7490	159	6	0	775	0	HTR6	1	20005114	Frame_Shift_Del	DEL	ACGAAGCACAGCA	TCGA-CV-7101-01A-11D-2012-08		20005114	229245507	1	40895											
KTI12	112970	broad.mit.edu	37	chr1	52498549	52498549	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaggaagcgtgagcaagtcCccggggacagcgctcttctg	8	6	14	13	3	2	1	0	1	2	0	3	3	3	3	3	3	3	2	3	3	2	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:52498549C>A	uc001ctj.1	-	1	924	c.885G>T	c.(883-885)GGG>GGT	p.G295G	TXNDC12_uc001cti.2_Intron	NM_138417	NP_612426	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated	295							ATP binding			central_nervous_system(2)	2						TGAGCAAGTCCCCGGGGACAG	0.597													58	45					2.12129e-23	4.67055e-23	1	0	A	52498549	A	A	52498549	2	1	223	1	0	0	0	0	0	0	0	1	8624	610	22	4		4	KTI12	1	52498549	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	32493435	52498549	196752072	2	40896											
DPYD	1806	broad.mit.edu	37	chr1	97771778	97771778	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacaatatcagtgacatttgGggtcagcttggcaaaaaaag	15	9	10	7	0	2	1	2	1	0	0	2	1	2	1	0	3	1	2	0	3	5	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:97771778G>C	uc001drv.2	-	17	2271	c.2134C>G	c.(2134-2136)CCA>GCA	p.P712A		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	712					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GTGACATTTGGGGTCAGCTTG	0.448													34	146					0	0	0	0	C	97771778	C	C	97771778	3	2	223	1	0	0	0	0	1	0	0	0	4767	1232	43	4	971	4	DPYD	1	97771778	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	45273229	97771778	151478843	3	40897											
AMY2A	279	broad.mit.edu	37	chr1	104160645	104160645	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtgggaaagataccaaccaGttagctataaattatgcaca	16	9	9	7	0	0	1	0	0	0	1	0	2	0	2	2	2	4	3	2	2	8	5			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:104160645G>T	uc001dut.2	+	2	302	c.238G>T	c.(238-240)GTT>TTT	p.V80F	AMY2A_uc010ouq.1_Missense_Mutation_p.V80F	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	80					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	ATACCAACCAGTTAGCTATAA	0.353													54	76					2.27459e-33	5.05241e-33	1	0	T	104160645	T	T	104160645	3	4	223	1	0	0	0	0	1	0	0	0	594	1029	36	4	244	4	AMY2A	1	104160645	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	6388867	104160645	145089976	4	40898											
YY1AP1	55249	broad.mit.edu	37	chr1	155629472	155629472	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaatccactgatttcctcTgtagcatcttcaggttccat	10	14	6	11	0	3	2	1	1	2	1	6	2	6	2	3	1	1	3	3	1	2	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:155629472T>A	uc001fln.2	-	11	2391	c.2367A>T	c.(2365-2367)ACA>ACT	p.T789T	YY1AP1_uc001flg.2_Silent_p.T528T|YY1AP1_uc010pgg.1_Silent_p.T628T|YY1AP1_uc010pgh.1_Silent_p.T732T|YY1AP1_uc010pgi.1_Silent_p.T881T|YY1AP1_uc001flh.2_Silent_p.T861T|YY1AP1_uc009wqt.2_Silent_p.T712T|YY1AP1_uc001flk.2_Silent_p.T732T|YY1AP1_uc001fll.2_Silent_p.T743T|YY1AP1_uc009wqv.2_Silent_p.T460T|YY1AP1_uc001flm.2_Silent_p.T732T|YY1AP1_uc001fli.2_Silent_p.T743T|YY1AP1_uc009wqu.2_Silent_p.T576T|YY1AP1_uc001flj.2_Silent_p.T723T|YY1AP1_uc009wqw.2_Silent_p.T712T|YY1AP1_uc001flo.2_Silent_p.T677T|YY1AP1_uc001flp.2_Silent_p.T743T	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	789					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TGATTTCCTCTGTAGCATCTT	0.378													7	213					0	0	0	0	A	155629472	A	A	155629472	2	1	223	1	0	0	0	0	0	0	0	1	17576	1567	55	5		5	YY1AP1	1	155629472	Silent	SNP	T	TCGA-CV-7101-01A-11D-2012-08	51468827	155629472	93621149	5	40899											
SEMA4A	64218	broad.mit.edu	37	chr1	156142765	156142765	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gacagcccagggccttgatgGgcacagccatcttgtcatgt	8	9	12	12	0	2	1	1	1	1	0	2	2	2	1	3	2	2	1	3	2	0	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:156142765G>A	uc001fnl.2	+	11	1387	c.1283G>A	c.(1282-1284)GGG>GAG	p.G428E	SEMA4A_uc009wrq.2_Missense_Mutation_p.G428E|SEMA4A_uc001fnm.2_Missense_Mutation_p.G428E|SEMA4A_uc001fnn.2_Missense_Mutation_p.G296E|SEMA4A_uc001fno.2_Missense_Mutation_p.G428E	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	428	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					GGCCTTGATGGGCACAGCCAT	0.577													11	41					0	0	0	0	A	156142765	A	A	156142765	3	1	223	1	0	0	0	0	1	0	0	0	14096	1232	43	4	1321	4	SEMA4A	1	156142765	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	513293	156142765	93107856	6	40900											
UCK2	7371	broad.mit.edu	37	chr1	165860556	165860556	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtatgactttgtctcccattCccggtaagtgagctgttctg	6	15	10	10	1	2	2	0	2	2	0	4	2	3	2	2	1	1	4	2	1	2	5			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:165860556C>G	uc001gdp.2	+	3	534	c.353C>G	c.(352-354)TCC>TGC	p.S118C	UCK2_uc010plb.1_Missense_Mutation_p.P28A	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	118					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					GTCTCCCATTCCCGGTAAGTG	0.502													7	20					0	0	0	0	G	165860556	G	G	165860556	3	3	223	1	0	0	0	0	1	0	0	0	16992	855	30	2	363	2	UCK2	1	165860556	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	9717791	165860556	83390065	7	40901											
HMCN1	83872	broad.mit.edu	37	chr1	186158872	186158872	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgaaaacctgaaaggagtGgtgtatacaacacgaccact	16	7	10	8	1	0	2	0	2	0	0	0	5	0	3	2	2	3	1	2	2	6	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:186158872G>A	uc001grq.1	+	107	16999	c.16770G>A	c.(16768-16770)GTG>GTA	p.V5590V	HMCN1_uc001grs.1_Silent_p.V1042V	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5590					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGAAAGGAGTGGTGTATACAA	0.493													19	32					0	0	0	0	A	186158872	A	A	186158872	2	1	223	1	0	0	0	0	0	0	0	1	7259	1335	47	4		4	HMCN1	1	186158872	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	20298316	186158872	63091749	8	40902											
USH2A	7399	broad.mit.edu	37	chr1	215847971	215847971	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacacactagctgtgcaacCtccattcgtgcaggctacaa	11	9	8	13	1	0	1	0	1	0	0	2	1	1	1	2	1	5	4	2	1	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:215847971C>T	uc001hku.1	-	63	13669	c.13282G>A	c.(13282-13284)GGT>AGT	p.G4428S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4428	Extracellular (Potential).|Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCTGTGCAACCTCCATTCGTG	0.512										HNSCC(13;0.011)			4	53					0	0	0	0	T	215847971	T	T	215847971	3	4	223	1	0	0	0	0	1	0	0	0	17104	681	24	4	2366	4	USH2A	1	215847971	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	29689099	215847971	33402650	9	40903											
TGFB2	7042	broad.mit.edu	37	chr1	218520300	218520300	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaaggcgagccggagggCggccgcctgcgagcgcgaga	8	1	21	11	7	0	2	0	0	0	2	0	7	0	3	3	5	3	0	3	5	1	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:218520300C>T	uc001hlm.2	+	1	910	c.257C>T	c.(256-258)GCG>GTG	p.A86V	TGFB2_uc001hll.2_Missense_Mutation_p.A86V|TGFB2_uc001hln.2_Missense_Mutation_p.A86V|TGFB2_uc010pue.1_RNA|TGFB2_uc001hlo.2_RNA	NM_003238	NP_003229	P61812	TGFB2_HUMAN	transforming growth factor, beta 2 isoform 2	86					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding				0				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		AGCCGGAGGGCGGCCGCCTGC	0.587													13	21					0	0	0	0	T	218520300	T	T	218520300	3	4	223	1	0	0	0	0	1	0	0	0	15884	768	27	1	259	1	TGFB2	1	218520300	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	2672329	218520300	30730321	10	40904											
EPHX1	2052	broad.mit.edu	37	chr1	226033041	226033041	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttcctgtcggtgctggagcGgcaatgacccacccctctcc	5	9	11	16	2	1	1	0	1	1	0	4	2	2	2	5	3	2	3	5	3	1	1	rs2234701		TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:226033041G>A	uc001hpk.2	+	9	1441	c.1361G>A	c.(1360-1362)CGG>CAG	p.R454Q	EPHX1_uc001hpl.2_Missense_Mutation_p.R454Q	NM_001136018	NP_001129490	P07099	HYEP_HUMAN	epoxide hydrolase 1	454					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			ovary(3)|lung(1)	4	Breast(184;0.197)					GTGCTGGAGCGGCAATGACCC	0.607													11	23					0	0	0	0	A	226033041	A	A	226033041	3	1	223	1	0	0	0	0	1	0	0	0	5203	1116	39	1	1391	1	EPHX1	1	226033041	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	7512741	226033041	23217580	11	40905											
ACTN2	88	broad.mit.edu	37	chr1	236911018	236911018	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatgatcggtgccagaaaatTtgtgaccagtgggaccgact	12	9	12	8	2	0	3	0	2	0	1	1	5	0	4	3	2	1	0	3	2	3	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:236911018T>C	uc001hyf.2	+	13	1662	c.1458T>C	c.(1456-1458)ATT>ATC	p.I486I	ACTN2_uc001hyg.2_Silent_p.I278I|ACTN2_uc009xgi.1_Silent_p.I486I|ACTN2_uc010pxu.1_Silent_p.I175I|ACTN2_uc001hyh.2_Silent_p.I174I	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	486	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GCCAGAAAATTTGTGACCAGT	0.408													3	29					0	0	0	0	C	236911018	C	C	236911018	2	2	223	1	0	0	0	0	0	0	0	1	205	1829	64	5		5	ACTN2	1	236911018	Silent	SNP	T	TCGA-CV-7101-01A-11D-2012-08	10877977	236911018	12339603	12	40906											
RYR2	6262	broad.mit.edu	37	chr1	237675051	237675051	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctccaagctgcctgaacagGagcgcaattacaacttacaa	14	8	7	12	1	1	1	0	1	1	0	2	2	1	2	2	1	7	2	2	1	7	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:237675051G>A	uc001hyl.1	+	24	2902	c.2782G>A	c.(2782-2784)GAG>AAG	p.E928K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	928	Cytoplasmic (By similarity).|1.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCCTGAACAGGAGCGCAATTA	0.403													3	12					0	0	0	0	A	237675051	A	A	237675051	3	1	223	1	0	0	0	0	1	0	0	0	13834	1175	41	2	2876	2	RYR2	1	237675051	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	764033	237675051	11575570	13	40907											
RYR2	6262	broad.mit.edu	37	chr1	237813233	237813233	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcggtacctttgcacagcCgtcttgccattgttaacaag	10	12	8	11	2	1	0	0	0	1	0	2	0	1	0	3	1	5	3	3	1	4	5			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:237813233C>T	uc001hyl.1	+	50	7689	c.7569C>T	c.(7567-7569)GCC>GCT	p.A2523A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2523	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTGCACAGCCGTCTTGCCAT	0.463													41	118					0	0	0	0	T	237813233	T	T	237813233	2	4	223	1	0	0	0	0	0	0	0	1	13834	639	23	1		1	RYR2	1	237813233	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	138182	237813233	11437388	14	40908											
ZP4	57829	broad.mit.edu	37	chr1	238050710	238050710	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caggaagtaaatggaaactgGaacagaacaaaagcttgtgt	18	7	11	5	0	0	1	0	0	0	1	0	4	0	4	0	3	4	2	0	3	8	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:238050710G>C	uc001hym.2	-	5	705	c.705C>G	c.(703-705)TTC>TTG	p.F235L	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	235	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ATGGAAACTGGAACAGAACAA	0.522													12	170					0	0	0	0	C	238050710	C	C	238050710	3	2	223	1	0	0	0	0	1	0	0	0	18285	1165	41	2	949	2	ZP4	1	238050710	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	237477	238050710	11199911	15	40909											
CHRM3	1131	broad.mit.edu	37	chr1	240071149	240071149	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacctacatcatcatgaatcGatgggccttagggaacttgg	11	10	11	9	1	2	1	2	1	0	0	3	4	2	2	2	3	2	0	2	3	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:240071149G>A	uc001hyp.2	+	5	1177	c.398G>A	c.(397-399)CGA>CAA	p.R133Q		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	133	Extracellular (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	ATCATGAATCGATGGGCCTTA	0.473													25	63					0	0	0	0	A	240071149	A	A	240071149	3	1	223	1	0	0	0	0	1	0	0	0	3393	1058	37	1	400	1	CHRM3	1	240071149	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	2020439	240071149	9179472	16	40910											
PLD5	200150	broad.mit.edu	37	chr1	242451674	242451674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtagcttacctgacatgctGatggatgagtgtggttgaga	9	13	14	5	0	0	4	0	4	0	1	0	6	0	5	1	2	3	4	1	2	2	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:242451674G>A	uc001hzn.1	-	3	612	c.485C>T	c.(484-486)TCA>TTA	p.S162L	PLD5_uc001hzl.3_Missense_Mutation_p.S100L|PLD5_uc001hzm.3_Intron|PLD5_uc001hzo.1_Missense_Mutation_p.S70L			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	162						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CTGACATGCTGATGGATGAGT	0.428													12	64					0	0	0	0	A	242451674	A	A	242451674	3	1	223	1	0	0	0	0	1	0	0	0	12104	1294	45	2	1157	2	PLD5	1	242451674	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	2380525	242451674	6798947	17	40911											
CNST	163882	broad.mit.edu	37	chr1	246810610	246810610	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctctgcagcgctgaagcCacgttagcgctccacaccca	8	7	9	17	3	1	1	0	1	1	0	2	1	2	1	3	0	5	5	3	0	2	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:246810610C>T	uc001ibp.2	+	9	1485	c.1107C>T	c.(1105-1107)GCC>GCT	p.A369A	CNST_uc001ibo.3_Silent_p.A369A	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	369					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						GCGCTGAAGCCACGTTAGCGC	0.587											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	97					0	0	0	0	T	246810610	T	T	246810610	2	4	223	1	0	0	0	0	0	0	0	1	3649	581	21	4		4	CNST	1	246810610	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	4358936	246810610	2440011	18	40912											
OR2B11	127623	broad.mit.edu	37	chr1	247614634	247614634	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagccataggagagaaggatGagagccaggggcaccaacac	16	2	14	9	0	0	2	0	1	0	2	0	6	0	4	3	4	3	1	3	4	4	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:247614634G>A	uc010pyx.1	-	1	651	c.651C>T	c.(649-651)CTC>CTT	p.L217L		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AGAGAAGGATGAGAGCCAGGG	0.582													7	50					0	0	0	0	A	247614634	A	A	247614634	2	1	223	1	0	0	0	0	0	0	0	1	11042	1277	45	2		2	OR2B11	1	247614634	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	804024	247614634	1635987	19	40913											
OR2W3	343171	broad.mit.edu	37	chr1	248059699	248059699	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccagttcttcccaggaccagGgcatgttcctcatgctcttc	6	12	8	15	0	3	0	1	0	2	0	6	1	5	1	4	2	1	4	4	2	0	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr1:248059699G>A	uc001idp.1	+	3	1080	c.811G>A	c.(811-813)GGC>AGC	p.G271S	OR2W3_uc010pzb.1_Missense_Mutation_p.G271S	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCAGGACCAGGGCATGTTCCT	0.532													24	80					0	0	0	0	A	248059699	A	A	248059699	3	1	223	1	0	0	0	0	1	0	0	0	11087	1232	43	4	813	4	OR2W3	1	248059699	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	445065	248059699	1190922	20	40914											
TPO	7173	broad.mit.edu	37	chr2	1497685	1497685	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caagatcctggacttgtacaAgcatcctgacaacatcgatg	13	9	8	11	1	0	2	0	1	0	1	3	4	2	3	2	1	3	2	2	1	4	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr2:1497685A>G	uc002qww.2	+	11	1971	c.1880A>G	c.(1879-1881)AAG>AGG	p.K627R	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.K570R|TPO_uc002qwr.2_Missense_Mutation_p.K627R|TPO_uc002qwx.2_Missense_Mutation_p.K570R|TPO_uc010yio.1_Missense_Mutation_p.K454R|TPO_uc010yip.1_Missense_Mutation_p.K627R|TPO_uc002qwy.1_5'UTR|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	627	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GACTTGTACAAGCATCCTGAC	0.612													12	33					0	0	0	0	G	1497685	G	G	1497685	3	3	223	1	0	0	0	0	1	0	0	0	16477	72	3	5	1918	5	TPO	2	1497685	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08		1497685	241701688	21	40915											
NLRC4	58484	broad.mit.edu	37	chr2	32475056	32475056	+	Frame_Shift_Del	DEL	T	-	-																															cacctgtgtcttctgcagccTtttcccatgaagccatagct																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr2:32475056delT	uc002roi.2	-	4	2123	c.1877delA	c.(1876-1878)AAGfs	p.K626fs	NLRC4_uc002roj.1_Frame_Shift_Del_p.K626fs|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	626					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTCTGCAGCCTTTTCCCATGA	0.458													---	---	---								-	32475056	-	-	32475056	7	5	223	1	0	1	0	1	0	0	0	0	10523	1609	56	0	1221	0	NLRC4	2	32475056	Frame_Shift_Del	DEL	T	TCGA-CV-7101-01A-11D-2012-08	30977371	32475056	210724317	22	40916											
SNRNP200	23020	broad.mit.edu	37	chr2	96953231	96953231	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggggaaattcttcttctCaatcttcttcactacttcct	10	16	4	11	0	6	0	2	0	5	0	8	1	7	1	1	2	1	0	1	2	4	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr2:96953231C>T	uc002svu.2	-	26	3516	c.3430G>A	c.(3430-3432)GAG>AAG	p.E1144K	SNRNP200_uc002svt.2_5'Flank|SNRNP200_uc010yuj.1_5'Flank|SNRNP200_uc002svv.1_5'Flank|SNRNP200_uc002svw.1_Missense_Mutation_p.E216K	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1144	SEC63 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						TTCTTCTTCTCAATCTTCTTC	0.517													31	55					0	0	0	0	T	96953231	T	T	96953231	3	4	223	1	0	0	0	0	1	0	0	0	14916	835	29	2	3060	2	SNRNP200	2	96953231	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	64478175	96953231	146246142	23	40917											
TTN	7273	broad.mit.edu	37	chr2	179571656	179571657	+	Missense_Mutation	DNP	GG	TT	TT																															ccatctaccgcagctttcttGgttgctggggccacagctgg																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr2:179571656_179571657GG>TT	uc010zfg.1	-	98	25558_25559	c.25334_25335CC>AA	c.(25333-25335)ACC>AAA	p.T8445K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T5106K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9372							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTTTCTTGGTTGCTGGGGC	0.396													5	13					0	0	0	0	TT	179571657	TT	TT	179571656	3	4	223	1	0	0	0	0	1	0	0	0	16803	1335	47	4	75510	4	TTN	2	179571656	Missense_Mutation	DNP	GG	TCGA-CV-7101-01A-11D-2012-08	82618425	179571656	63627717	24	40918											
CDK15	65061	broad.mit.edu	37	chr2	202744779	202744779	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggttcctgaagctgaagacCtggcctcccagatgctaaaa	11	8	11	11	0	0	4	0	2	0	2	2	4	2	4	4	2	2	3	4	2	4	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr2:202744779C>A	uc002uyt.2	+	12	1136	c.1087C>A	c.(1087-1089)CTG>ATG	p.L363M	CDK15_uc002uys.2_Missense_Mutation_p.L312M|CDK15_uc010ftn.1_Missense_Mutation_p.L312M|CDK15_uc002uyu.1_RNA	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	363	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	AGCTGAAGACCTGGCCTCCCA	0.507													8	29					1.11149e-13	2.3543e-13	1	0	A	202744779	A	A	202744779	3	1	223	1	0	0	0	0	1	0	0	0	3146	680	24	4	976	4	CDK15	2	202744779	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	23173123	202744779	40454594	25	40919											
RNF25	64320	broad.mit.edu	37	chr2	219528721	219528721	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggcccagggactccctccGagtaccaggccggtatgctc	7	6	12	16	2	0	0	0	0	0	0	3	2	2	1	5	4	2	3	5	4	2	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr2:219528721G>A	uc002vit.2	-	10	1427	c.1339C>T	c.(1339-1341)CGG>TGG	p.R447W	RNF25_uc010fvw.2_Missense_Mutation_p.R335W	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	447					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GACTCCCTCCGAGTACCAGGC	0.607													9	95					0	0	0	0	A	219528721	A	A	219528721	3	1	223	1	0	0	0	0	1	0	0	0	13550	1057	37	1	44	1	RNF25	2	219528721	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	16783942	219528721	23670652	26	40920											
COL4A4	1286	broad.mit.edu	37	chr2	227924130	227924130	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccctcataccttcagcccCtggacatcccggatcacctc	8	8	6	19	1	3	0	3	0	0	0	5	2	4	2	6	2	3	0	6	2	1	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr2:227924130C>G	uc010zlt.1	-	28	3028	c.2374G>C	c.(2374-2376)GGG>CGG	p.G792R		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	792	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCTTCAGCCCCTGGACATCCC	0.537													4	151					0	0	0	0	G	227924130	G	G	227924130	3	3	223	1	0	0	0	0	1	0	0	0	3708	681	24	4	2782	4	COL4A4	2	227924130	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	8395409	227924130	15275243	27	40921											
DIS3L2	129563	broad.mit.edu	37	chr2	233198650	233198650	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacttcacctcgcccatccGccgctttgccgacgtcctgg	5	9	8	19	5	1	0	1	0	0	0	4	1	3	0	6	1	1	1	6	1	0	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr2:233198650G>A	uc010fxz.2	+	17	2387	c.2111G>A	c.(2110-2112)CGC>CAC	p.R704H	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA|DIS3L2_uc002vsp.1_5'Flank	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	704							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		TCGCCCATCCGCCGCTTTGCC	0.667													10	94					0	0	0	0	A	233198650	A	A	233198650	3	1	223	1	0	0	0	0	1	0	0	0	4559	1087	38	1	2173	1	DIS3L2	2	233198650	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	5274520	233198650	10000723	28	40922											
MTERFD2	130916	broad.mit.edu	37	chr2	242035433	242035433	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctattcctcctcgtcgtcgtCctcatcctcatcattgtcct	4	16	4	17	3	3	0	3	0	0	0	11	0	8	0	5	0	0	0	5	0	1	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr2:242035433C>T	uc002wan.1	-	3	1706	c.1213G>A	c.(1213-1215)GAC>AAC	p.D405N	MTERFD2_uc010zoj.1_Missense_Mutation_p.D188N	NM_182501	NP_872307	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	376										ovary(1)	1		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		tcgtcgtcgtcctcatcctca	0.199													5	68					0	0	0	0	T	242035433	T	T	242035433	3	4	223	1	0	0	0	0	1	0	0	0	9973	855	30	2	23	2	MTERFD2	2	242035433	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	8836783	242035433	1163940	29	40923											
GNL3	26354	broad.mit.edu	37	chr3	52723170	52723170	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatgtcctcaggtagaagaGgccattgtccagagtggaca	12	8	13	8	0	1	4	1	0	0	4	3	5	3	5	3	3	0	1	3	3	2	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:52723170G>A	uc003dfd.2	+	6	662	c.489G>A	c.(487-489)GAG>GAA	p.E163E	GNL3_uc011beh.1_RNA|GNL3_uc003dfe.2_Silent_p.E151E|GNL3_uc003dff.2_Silent_p.E151E|SNORD19_uc003dfg.1_5'Flank|SNORD19B_uc010hml.1_5'Flank	NM_014366	NP_055181	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3	163					regulation of cell proliferation	nucleolus	GTP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		AGGTAGAAGAGGCCATTGTCC	0.448													13	83					0	0	0	0	A	52723170	A	A	52723170	2	1	223	1	0	0	0	0	0	0	0	1	6574	991	35	4		4	GNL3	3	52723170	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08		52723170	145299260	30	40924											
ZNF654	55279	broad.mit.edu	37	chr3	88188518	88188518	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaggcatgcccaggctcatCagaaaaaaggcagttttgca	14	8	10	9	0	2	1	2	0	0	1	2	1	2	1	1	3	2	5	1	3	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:88188518C>T	uc003dqv.2	+	1	257	c.58C>T	c.(58-60)CAG>TAG	p.Q20*	CGGBP1_uc003dqu.2_Intron	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		CCAGGCTCATCAGAAAAAAGG	0.383													10	21					0	0	0	0	T	88188518	T	T	88188518	4	4	223	1	0	0	0	0	0	1	0	0	18134	827	29	2	60	2	ZNF654	3	88188518	Nonsense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	35465348	88188518	109833912	31	40925											
CEP97	79598	broad.mit.edu	37	chr3	101476483	101476483	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgattcttctagaacccGtcattcaagtgaattcttgg	9	16	8	8	1	5	3	2	2	3	1	5	3	5	3	1	1	1	1	1	1	4	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:101476483G>A	uc003dvk.1	+	9	1060	c.1033G>A	c.(1033-1035)GTC>ATC	p.V345I	CEP97_uc010hpm.1_Missense_Mutation_p.V311I|CEP97_uc011bhf.1_Intron|CEP97_uc003dvl.1_Missense_Mutation_p.V41I|CEP97_uc003dvm.1_Missense_Mutation_p.V183I	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	345	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						TCTAGAACCCGTCATTCAAGT	0.323													10	45					0	0	0	0	A	101476483	A	A	101476483	3	1	223	1	0	0	0	0	1	0	0	0	3278	1145	40	1	1067	1	CEP97	3	101476483	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	13287965	101476483	96545947	32	40926											
CD200R1	131450	broad.mit.edu	37	chr3	112648206	112648206	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtacagttggtttccttggtCtcatttgtttctttcttgta	4	22	8	7	0	3	0	1	0	3	0	5	0	4	0	1	2	1	5	1	2	2	9			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:112648206C>G	uc003dzk.1	-	3	515	c.282G>C	c.(280-282)GAG>GAC	p.E94D	CD200R1_uc003dzj.1_Missense_Mutation_p.E117D|CD200R1_uc011bhx.1_Missense_Mutation_p.E72D|CD200R1_uc003dzl.1_Missense_Mutation_p.E117D|CD200R1_uc003dzm.1_Missense_Mutation_p.E94D	NM_170780	NP_740750	Q8TD46	MO2R1_HUMAN	CD200 receptor 1 isoform d	94	Ig-like V-type.|Extracellular (Potential).				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(2)|pancreas(1)	3						TTTCCTTGGTCTCATTTGTTT	0.448													8	109					0	0	0	0	G	112648206	G	G	112648206	3	3	223	1	0	0	0	0	1	0	0	0	2996	912	32	2	762	2	CD200R1	3	112648206	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	11171723	112648206	85374224	33	40927											
KIAA2018	205717	broad.mit.edu	37	chr3	113375488	113375488	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatccccattctctgctctgAattagaagatgtctttccaa	10	15	5	11	0	3	3	0	1	3	2	6	3	5	3	3	0	1	1	3	0	5	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:113375488A>G	uc003eam.2	-	7	5452	c.5041T>C	c.(5041-5043)TCA>CCA	p.S1681P	KIAA2018_uc003eal.2_Missense_Mutation_p.S1625P	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1681					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						CTCTGCTCTGAATTAGAAGAT	0.413													100	38					0	0	0	0	G	113375488	G	G	113375488	3	3	223	1	0	0	0	0	1	0	0	0	8307	246	9	5	1700	5	KIAA2018	3	113375488	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08	727282	113375488	84646942	34	40928											
EAF2	55840	broad.mit.edu	37	chr3	121563320	121563320	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgacttcaaacctgcttctAttgacacttcttctgaagga	11	14	6	10	0	4	3	1	3	3	0	4	4	4	4	1	1	2	1	1	1	3	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:121563320A>G	uc003een.2	+	2	226	c.127A>G	c.(127-129)ATT>GTT	p.I43V	EAF2_uc003eeo.2_5'UTR	NM_018456	NP_060926	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	43	Necessary for interaction with ELL.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding				0				GBM - Glioblastoma multiforme(114;0.0972)		ACCTGCTTCTATTGACACTTC	0.318													12	85					0	0	0	0	G	121563320	G	G	121563320	3	3	223	1	0	0	0	0	1	0	0	0	4898	449	16	5	133	5	EAF2	3	121563320	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08	8187832	121563320	76459110	35	40929											
PARP15	165631	broad.mit.edu	37	chr3	122345843	122345843	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaaagagacctctctgcAtcactgaactttcagtccac	15	9	5	12	0	3	2	2	1	1	1	5	3	4	2	2	0	2	1	2	0	4	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:122345843A>G	uc003efm.2	+	9	1467	c.1401A>G	c.(1399-1401)GCA>GCG	p.A467A	PARP15_uc003efn.2_Intron|PARP15_uc003efo.1_Silent_p.A214A|PARP15_uc003efp.1_Silent_p.A233A|PARP15_uc011bjt.1_Intron	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		ACCTCTCTGCATCACTGAACT	0.353													8	47					0	0	0	0	G	122345843	G	G	122345843	2	3	223	1	0	0	0	0	0	0	0	1	11513	204	8	5		5	PARP15	3	122345843	Silent	SNP	A	TCGA-CV-7101-01A-11D-2012-08	782523	122345843	75676587	36	40930											
STAG1	10274	broad.mit.edu	37	chr3	136221571	136221571	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctgggtattatcctgatGaatactgaggtttaaggcaa	11	14	10	6	0	1	3	0	3	1	0	3	3	2	3	1	3	1	3	1	3	6	5			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:136221571G>T	uc003era.1	-	8	1019	c.727C>A	c.(727-729)CAT>AAT	p.H243N	STAG1_uc003erb.1_Missense_Mutation_p.H243N|STAG1_uc003erc.1_Missense_Mutation_p.H17N|STAG1_uc010hua.1_Missense_Mutation_p.H106N|STAG1_uc003erd.2_Missense_Mutation_p.H146N	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	243					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						TTATCCTGATGAATACTGAGG	0.363													9	60					5.4927e-09	1.13006e-08	1	0	T	136221571	T	T	136221571	3	4	223	1	0	0	0	0	1	0	0	0	15308	1290	45	2	3157	2	STAG1	3	136221571	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	13875728	136221571	61800859	37	40931											
DBR1	51163	broad.mit.edu	37	chr3	137889026	137889034	+	In_Frame_Del	DEL	CAAAATGAC	-	-																															tgaattataaggggggcactCaaaatgaccttagattgaag																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:137889026_137889034delCAAAATGAC	uc003erv.2	-	4	540_548	c.404_412delGTCATTTTG	c.(403-414)GGTCATTTTGAG>GAG	p.GHF135del	DBR1_uc003eru.2_In_Frame_Del_p.GHF84del	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	135_137						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						GGGGGGCACTCAAAATGACCTTAGATTGA	0.316													---	---	---								-	137889034	-	-	137889026	7	5	223	1	0	1	0	1	0	0	0	0	4274	835	29	0	1242	0	DBR1	3	137889026	In_Frame_Del	DEL	CAAAATGAC	TCGA-CV-7101-01A-11D-2012-08	1667455	137889026	60133404	38	40932											
ATR	545	broad.mit.edu	37	chr3	142278147	142278147	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccttatcaatggttgcctCcaggtccagtttctgaacag	9	12	8	12	0	2	1	1	1	1	0	4	1	4	1	4	2	2	2	4	2	3	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:142278147C>T	uc003eux.3	-	7	1800	c.1678G>A	c.(1678-1680)GAG>AAG	p.E560K		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	560					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						ATGGTTGCCTCCAGGTCCAGT	0.348								Other_conserved_DNA_damage_response_genes					7	47					0	0	0	0	T	142278147	T	T	142278147	3	4	223	1	0	0	0	0	1	0	0	0	1206	864	30	2	6420	2	ATR	3	142278147	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	4389121	142278147	55744283	39	40933											
PLD1	5337	broad.mit.edu	37	chr3	171451288	171451288	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtatctttgtcaagtaatcTtccagttgtttctgtaatgc	9	18	7	7	0	4	0	1	0	3	0	5	0	5	0	1	0	1	5	1	0	4	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:171451288T>C	uc003fhs.2	-	6	668	c.552A>G	c.(550-552)GAA>GAG	p.E184E	PLD1_uc003fht.2_Silent_p.E184E	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	184	PX.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TCAAGTAATCTTCCAGTTGTT	0.284													4	37					0	0	0	0	C	171451288	C	C	171451288	2	2	223	1	0	0	0	0	0	0	0	1	12100	1606	56	5		5	PLD1	3	171451288	Silent	SNP	T	TCGA-CV-7101-01A-11D-2012-08	29173141	171451288	26571142	40	40934											
MFN1	55669	broad.mit.edu	37	chr3	179082171	179082171	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttgttttggtcgcaaactCtgaatcaacactaatgaata	13	14	6	8	1	2	2	1	2	1	0	3	2	2	2	0	1	2	2	0	1	6	5			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:179082171C>G	uc003fjs.2	+	6	749	c.623C>G	c.(622-624)TCT>TGT	p.S208C	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.S236C|MFN1_uc010hxc.2_Missense_Mutation_p.S61C	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	208	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			GTCGCAAACTCTGAATCAACA	0.373													3	36					0	0	0	0	G	179082171	G	G	179082171	3	3	223	1	0	0	0	0	1	0	0	0	9576	913	32	2	641	2	MFN1	3	179082171	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	7630883	179082171	18940259	41	40935											
LAMP3	27074	broad.mit.edu	37	chr3	182871533	182871533	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttatacagagtctgcttccGtttagaacctgataaattcc	11	15	6	9	1	1	3	0	1	1	2	3	3	3	3	3	0	3	2	3	0	6	8	rs140803277	by1000genomes	TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:182871533G>A	uc003flh.3	-	2	920	c.696C>T	c.(694-696)AAC>AAT	p.N232N		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	232	Lumenal (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			GTCTGCTTCCGTTTAGAACCT	0.502													12	121					0	0	0	0	A	182871533	A	A	182871533	2	1	223	1	0	0	0	0	0	0	0	1	8659	1136	40	1		1	LAMP3	3	182871533	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	3789362	182871533	15150897	42	40936											
EIF4G1	1981	broad.mit.edu	37	chr3	184046477	184046477	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgacatcccccacgtgtggCtctacctagcggaactggta	8	10	10	13	2	1	1	0	1	1	0	2	2	2	2	3	3	3	2	3	3	4	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:184046477C>T	uc003fnp.2	+	27	4210	c.4012C>T	c.(4012-4014)CTC>TTC	p.L1338F	EIF4G1_uc003fnt.2_Missense_Mutation_p.L1049F|EIF4G1_uc003fnq.2_Missense_Mutation_p.L1251F|EIF4G1_uc003fnr.2_Missense_Mutation_p.L1174F|EIF4G1_uc010hxx.2_Missense_Mutation_p.L1345F|EIF4G1_uc003fns.2_Missense_Mutation_p.L1298F|EIF4G1_uc010hxy.2_Missense_Mutation_p.L1345F|EIF4G1_uc003fnv.3_Missense_Mutation_p.L1339F|EIF4G1_uc003fnu.3_Missense_Mutation_p.L1338F|EIF4G1_uc003fnw.2_Missense_Mutation_p.L1345F|EIF4G1_uc003fnx.2_Missense_Mutation_p.L1143F|EIF4G1_uc003fny.3_Missense_Mutation_p.L1142F|EIF4G1_uc003foa.2_Missense_Mutation_p.L10F	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1338	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCACGTGTGGCTCTACCTAGC	0.532													8	189					0	0	0	0	T	184046477	T	T	184046477	3	4	223	1	0	0	0	0	1	0	0	0	5060	797	28	4	4110	4	EIF4G1	3	184046477	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	1174944	184046477	13975953	43	40937											
FGF12	2257	broad.mit.edu	37	chr3	191888366	191888366	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggcctgattcttgctggCggtacagtgtggaagaatag	8	11	14	8	2	1	2	0	1	1	1	2	3	1	3	1	4	2	2	1	4	4	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:191888366C>T	uc003fsx.2	-	4	1320	c.494G>A	c.(493-495)CGC>CAC	p.R165H	FGF12_uc003fsy.2_Missense_Mutation_p.R103H	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	165					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TTCTTGCTGGCGGTACAGTGT	0.393													13	293					0	0	0	0	T	191888366	T	T	191888366	3	4	223	1	0	0	0	0	1	0	0	0	5873	768	27	1	245	1	FGF12	3	191888366	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	7841889	191888366	6134064	44	40938											
ZDHHC19	131540	broad.mit.edu	37	chr3	195925231	195925231	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttggggctggggggttgaGagcagagggggacattggag	7	7	24	3	0	0	2	0	1	0	2	0	5	0	4	0	9	1	4	0	9	0	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:195925231G>A	uc003fwc.2	-	7	979	c.865C>T	c.(865-867)CTC>TTC	p.L289F	ZDHHC19_uc010hzz.2_RNA|ZDHHC19_uc010iaa.2_RNA|ZDHHC19_uc010iab.2_Intron	NM_001039617	NP_001034706	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC domain containing 19	289						integral to membrane	acyltransferase activity|zinc ion binding			ovary(3)	3	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		GGGGGGTTGAGAGCAGAGGGG	0.632													9	50					0	0	0	0	A	195925231	A	A	195925231	3	1	223	1	0	0	0	0	1	0	0	0	17676	942	33	2	68	2	ZDHHC19	3	195925231	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	4036865	195925231	2097199	45	40939											
SENP5	205564	broad.mit.edu	37	chr3	196612534	196612534	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacagacctaggacagaccCacaaccttctgactttccca	12	8	5	16	0	2	3	1	1	1	2	3	4	3	4	4	1	1	0	4	1	2	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr3:196612534C>T	uc003fwz.3	+	2	731	c.482C>T	c.(481-483)CCA>CTA	p.P161L	SENP5_uc011bty.1_Missense_Mutation_p.P161L	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	161					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AGGACAGACCCACAACCTTCT	0.468													5	61					0	0	0	0	T	196612534	T	T	196612534	3	4	223	1	0	0	0	0	1	0	0	0	14114	594	21	4	484	4	SENP5	3	196612534	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	687303	196612534	1409896	46	40940											
WFS1	7466	broad.mit.edu	37	chr4	6302536	6302536	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcgtcagcaacctcaccatCgacttcttcgccttcttcat	8	13	4	16	3	5	0	3	0	2	0	8	1	5	0	3	0	2	1	3	0	1	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr4:6302536C>T	uc003giy.2	+	8	1180	c.1014C>T	c.(1012-1014)ATC>ATT	p.I338I	WFS1_uc003gix.2_Silent_p.I338I|WFS1_uc003giz.2_Silent_p.I156I	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	338					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		ACCTCACCATCGACTTCTTCG	0.562													22	55					0	0	0	0	T	6302536	T	T	6302536	2	4	223	1	0	0	0	0	0	0	0	1	17428	874	31	1		1	WFS1	4	6302536	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08		6302536	184851740	47	40941											
FAM13A	10144	broad.mit.edu	37	chr4	89827587	89827587	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagcctcttgttaaaaggatGggcagggagttcttataata	13	12	11	5	0	2	0	0	0	2	0	2	2	2	2	1	3	1	3	1	3	6	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr4:89827587G>C	uc003hse.1	-	6	994	c.786C>G	c.(784-786)CCC>CCG	p.P262P	FAM13A_uc003hsf.1_Silent_p.P53P|FAM13A_uc003hsh.1_Silent_p.P76P	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	262					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						TTAAAAGGATGGGCAGGGAGT	0.368													20	258					0	0	0	0	C	89827587	C	C	89827587	2	2	223	1	0	0	0	0	0	0	0	1	5480	1335	47	4		4	FAM13A	4	89827587	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	83525051	89827587	101326689	48	40942											
GRID2	2895	broad.mit.edu	37	chr4	94145828	94145828	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgcttttcataagaagctgGaggaccgaaagtggcacagc	13	8	12	8	1	1	1	1	0	0	1	1	4	1	3	1	3	3	3	1	3	3	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr4:94145828G>A	uc011cdt.1	+	7	1285	c.1027G>A	c.(1027-1029)GAG>AAG	p.E343K	GRID2_uc011cdu.1_Missense_Mutation_p.E248K|GRID2_uc010ikz.1_Missense_Mutation_p.E24K	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	343	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TAAGAAGCTGGAGGACCGAAA	0.443													10	18					0	0	0	0	A	94145828	A	A	94145828	3	1	223	1	0	0	0	0	1	0	0	0	6811	1175	41	2	1053	2	GRID2	4	94145828	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	4318241	94145828	97008448	49	40943											
QRFPR	84109	broad.mit.edu	37	chr4	122250599	122250599	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgccatcactgaatgctTctcctttggtttcctccact	5	17	6	13	0	2	1	1	1	1	0	5	1	4	1	4	1	2	3	4	1	1	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr4:122250599T>G	uc010inj.1	-	6	1545	c.1166A>C	c.(1165-1167)GAA>GCA	p.E389A	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_3'UTR	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	389	Cytoplasmic (Potential).					plasma membrane	neuropeptide Y receptor activity				0						ACTGAATGCTTCTCCTTTGGT	0.428													13	143					0	0	0	0	G	122250599	G	G	122250599	3	3	223	1	0	0	0	0	1	0	0	0	12943	1783	62	5	133	5	QRFPR	4	122250599	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	28104771	122250599	68903677	50	40944											
SETD7	80854	broad.mit.edu	37	chr4	140439120	140439120	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acttggatacgtggttatagGgctcaggcacatcaatgacc	11	10	11	9	1	2	1	2	1	0	0	2	2	2	2	1	4	1	3	1	4	4	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr4:140439120G>C	uc003ihw.2	-	7	1125	c.839C>G	c.(838-840)CCC>CGC	p.P280R		NM_030648	NP_085151	Q8WTS6	SETD7_HUMAN	SET domain-containing protein 7	280	SET.				peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.156)					GTGGTTATAGGGCTCAGGCAC	0.493													7	84					0	0	0	0	C	140439120	C	C	140439120	3	2	223	1	0	0	0	0	1	0	0	0	14201	1232	43	4	269	4	SETD7	4	140439120	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	18188521	140439120	50715156	51	40945											
TIGD4	201798	broad.mit.edu	37	chr4	153692050	153692050	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caatctctgcttttttcttgCcactttccactgcatttatg	6	19	4	12	0	2	0	0	0	2	0	4	0	3	0	2	0	3	2	2	0	2	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr4:153692050C>T	uc003imy.2	-	2	889	c.107G>A	c.(106-108)GGC>GAC	p.G36D		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	36	HTH psq-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					TTTTTTCTTGCCACTTTCCAC	0.363													5	62					0	0	0	0	T	153692050	T	T	153692050	3	4	223	1	0	0	0	0	1	0	0	0	15964	739	26	4	1435	4	TIGD4	4	153692050	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	13252930	153692050	37462226	52	40946											
KIAA0947	23379	broad.mit.edu	37	chr5	5465121	5465121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggaaagaagttgttctagtCcagccgtcagtgcagtttca	11	11	11	8	1	3	1	2	0	1	1	4	2	4	2	2	1	2	4	2	1	3	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:5465121C>T	uc003jdm.3	+	13	5896	c.5674C>T	c.(5674-5676)CCA>TCA	p.P1892S		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1892										ovary(1)|central_nervous_system(1)	2						TTGTTCTAGTCCAGCCGTCAG	0.468													6	27					0	0	0	0	T	5465121	T	T	5465121	3	4	223	1	0	0	0	0	1	0	0	0	8241	855	30	2	5724	2	KIAA0947	5	5465121	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08		5465121	175450139	53	40947											
CDH10	1008	broad.mit.edu	37	chr5	24593411	24593411	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatcctgtatattcttcaagTaagaaaaattgattccacat	15	14	5	7	0	2	2	1	1	1	1	4	3	4	2	2	0	0	2	2	0	6	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:24593411T>G	uc003jgr.1	-	2	521	c.189A>C	c.(187-189)TTA>TTC	p.L63F	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	63	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ATTCTTCAAGTAAGAAAAATT	0.363										HNSCC(23;0.051)			16	94					0	0	0	0	G	24593411	G	G	24593411	3	3	223	1	0	0	0	0	1	0	0	0	3111	1635	57	5	2221	5	CDH10	5	24593411	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	19128290	24593411	156321849	54	40948											
DEPDC1B	55789	broad.mit.edu	37	chr5	59894929	59894929	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtttcttctttttctctttGttggagagtttggcatctgt	4	22	9	6	0	4	1	0	0	4	1	5	2	4	1	0	2	0	4	0	2	0	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:59894929G>T	uc003jsh.2	-	10	1474	c.1401C>A	c.(1399-1401)AAC>AAA	p.N467K	DEPDC1B_uc011cqm.1_Intron|DEPDC1B_uc011cqn.1_Intron	NM_018369	NP_060839	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B isoform 1	467					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)	1		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				TTTTCTCTTTGTTGGAGAGTT	0.338													8	13					0.000157383	0.000303871	1	0	T	59894929	T	T	59894929	3	4	223	1	0	0	0	0	1	0	0	0	4462	1368	48	4	196	4	DEPDC1B	5	59894929	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	35301518	59894929	121020331	55	40949											
APC	324	broad.mit.edu	37	chr5	112176386	112176386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaaggcagaagtacagatGaggctcaaggaggaaaaacc	18	3	13	7	0	1	4	1	1	0	3	1	6	1	6	1	4	2	3	1	4	6	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:112176386G>A	uc010jby.2	+	16	5475	c.5095G>A	c.(5095-5097)GAG>AAG	p.E1699K	APC_uc011cvt.1_Missense_Mutation_p.E1681K|APC_uc003kpz.3_Missense_Mutation_p.E1699K|APC_uc003kpy.3_Missense_Mutation_p.E1699K|APC_uc010jbz.2_Missense_Mutation_p.E1416K|APC_uc010jca.2_Missense_Mutation_p.E999K	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1699	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AAGTACAGATGAGGCTCAAGG	0.423		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			6	22					0	0	0	0	A	112176386	A	A	112176386	3	1	223	1	0	0	0	0	1	0	0	0	763	1291	45	2	5153	2	APC	5	112176386	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	52281457	112176386	68738874	56	40950											
SLC27A6	28965	broad.mit.edu	37	chr5	128359396	128359397	+	Frame_Shift_Ins	INS	-	A	A																															agggttggtgtattcatgtgINSaaaaaaggtaagacttctat																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:128359396_128359397insA	uc003kuy.2	+	7	1644_1645	c.1248_1249insA	c.(1246-1251)GTGAAAfs	p.V416fs	SLC27A6_uc003kuz.2_Frame_Shift_Ins_p.V416fs	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	416_417					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GTATTCATGTGAAAAAAGGTAA	0.277													---	---	---								A	128359397	A	A	128359396	7	5	223	1	0	1	1	0	0	0	0	0	14594	1277	45	0	1270	0	SLC27A6	5	128359396	Frame_Shift_Ins	INS	-	TCGA-CV-7101-01A-11D-2012-08	16183010	128359396	52555864	57	40951											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139876609	139876609	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgagcaacagtctccacCatcggcagaacagattgatt	13	9	9	10	1	1	5	0	3	1	2	3	5	1	5	2	1	3	2	2	1	2	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:139876609C>G	uc003lfs.1	+	15	2874	c.2750C>G	c.(2749-2751)CCA>CGA	p.P917R	ANKHD1_uc003lfq.1_Missense_Mutation_p.P936R|ANKHD1_uc003lfr.2_Missense_Mutation_p.P917R|ANKHD1_uc003lft.1_Intron|ANKHD1_uc003lfu.1_Missense_Mutation_p.P397R|ANKHD1_uc003lfv.1_Intron	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	917						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTCTCCACCATCGGCAGAA	0.413													32	44					0	0	0	0	G	139876609	G	G	139876609	3	3	223	1	0	0	0	0	1	0	0	0	629	594	21	4	2808	4	ANKHD1-EIF4EBP3	5	139876609	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	11517213	139876609	41038651	58	40952											
PCDHA5	56143	broad.mit.edu	37	chr5	140201942	140201942	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgaactttttagagctggtTttgaggaaatccttagatag	12	14	10	5	1	0	3	0	1	0	2	1	5	1	4	1	2	2	2	1	2	5	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:140201942T>G	uc003lhl.2	+	1	582	c.582T>G	c.(580-582)GTT>GTG	p.V194V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.V194V|PCDHA5_uc003lhj.1_Silent_p.V194V	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	194	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGAGCTGGTTTTGAGGAAAT	0.353													24	38					0	0	0	0	G	140201942	G	G	140201942	2	3	223	1	0	0	0	0	0	0	0	1	11581	1828	64	5		5	PCDHA5	5	140201942	Silent	SNP	T	TCGA-CV-7101-01A-11D-2012-08	325333	140201942	40713318	59	40953											
PCDHB7	56129	broad.mit.edu	37	chr5	140553578	140553578	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtgtgctccatccaggacGatgtccccttcatcctgaag	8	10	9	14	1	1	1	1	1	0	0	5	3	5	2	5	1	1	1	5	1	1	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:140553578G>A	uc003lit.2	+	1	1336	c.1162G>A	c.(1162-1164)GAT>AAT	p.D388N		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	388	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATCCAGGACGATGTCCCCTT	0.468													5	35					0	0	0	0	A	140553578	A	A	140553578	3	1	223	1	0	0	0	0	1	0	0	0	11601	1058	37	1	1164	1	PCDHB7	5	140553578	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	351636	140553578	40361682	60	40954											
PCDHGB5	56101	broad.mit.edu	37	chr5	140778379	140778379	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taagcggcaccactgagctcCggatccaggtaaccgacgcc	10	5	11	15	4	0	1	0	1	0	0	2	3	2	2	5	3	3	3	5	3	2	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:140778379C>T	uc003lkf.1	+	1	685	c.685C>T	c.(685-687)CGG>TGG	p.R229W	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.R229W	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	229	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACTGAGCTCCGGATCCAGGT	0.547													50	59					0	0	0	0	T	140778379	T	T	140778379	3	4	223	1	0	0	0	0	1	0	0	0	11620	643	23	1	687	1	PCDHGB5	5	140778379	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	224801	140778379	40136881	61	40955											
CYFIP2	26999	broad.mit.edu	37	chr5	156786087	156786087	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacctcatttcaagactatCtgcagactcctgggttatca	10	12	6	13	0	4	2	3	0	1	2	5	2	5	2	3	1	1	2	3	1	3	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:156786087C>A	uc003lwq.2	+	26	2886	c.2748C>A	c.(2746-2748)ATC>ATA	p.I916I	CYFIP2_uc011ddn.1_Silent_p.I890I|CYFIP2_uc011ddo.1_Silent_p.I720I|CYFIP2_uc003lwr.2_Silent_p.I916I|CYFIP2_uc003lws.2_Silent_p.I916I|CYFIP2_uc003lwt.2_Silent_p.I819I|CYFIP2_uc011ddp.1_Silent_p.I650I	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	941					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCAAGACTATCTGCAGACTCC	0.488													51	73					4.01344e-20	8.68425e-20	1	0	A	156786087	A	A	156786087	2	1	223	1	0	0	0	0	0	0	0	1	4155	903	32	2		2	CYFIP2	5	156786087	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	16007708	156786087	24129173	62	40956											
RNF145	153830	broad.mit.edu	37	chr5	158588301	158588301	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagatggcacaaatatcattGtgtttctcaagctgctcttt	10	15	7	9	0	3	1	2	0	2	1	4	1	3	1	0	1	2	4	0	1	3	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:158588301G>T	uc003lxp.2	-	10	1912	c.1599C>A	c.(1597-1599)CAC>CAA	p.H533Q	RNF145_uc011ddy.1_Missense_Mutation_p.H547Q|RNF145_uc003lxo.1_Missense_Mutation_p.H561Q|RNF145_uc011ddz.1_Missense_Mutation_p.H550Q|RNF145_uc010jiq.1_Missense_Mutation_p.H563Q	NM_144726	NP_653327	Q96MT1	RN145_HUMAN	ring finger protein 145	533						integral to membrane	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAATATCATTGTGTTTCTCAA	0.433													6	39					2.7689e-08	5.65035e-08	1	0	T	158588301	T	T	158588301	3	4	223	1	0	0	0	0	1	0	0	0	13512	1368	48	4	400	4	RNF145	5	158588301	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	1802214	158588301	22326959	63	40957											
UIMC1	51720	broad.mit.edu	37	chr5	176395738	176395738	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttttctcactagcctgctCtccttggccacattcattct	6	17	4	14	0	4	0	2	0	3	0	6	0	4	0	3	1	2	1	3	1	1	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr5:176395738C>G	uc011dfp.1	-	6	1185	c.1018G>C	c.(1018-1020)GAG>CAG	p.E340Q	UIMC1_uc003mfc.1_Missense_Mutation_p.E217Q|UIMC1_uc003mfd.1_Intron|UIMC1_uc003mfg.1_Intron|UIMC1_uc003mff.1_Intron	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	340	AIR.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTAGCCTGCTCTCCTTGGCCA	0.463													43	49					0	0	0	0	G	176395738	G	G	176395738	3	3	223	1	0	0	0	0	1	0	0	0	17039	922	32	2	1181	2	UIMC1	5	176395738	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	17807437	176395738	4519522	64	40958											
GMDS	2762	broad.mit.edu	37	chr6	1742785	1742785	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtagctataacgaagtcCtccggctcatcattctgcaa	11	10	7	13	2	3	0	2	0	1	0	5	1	5	0	3	1	3	4	3	1	5	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:1742785C>A	uc003mtq.2	-	8	997	c.807G>T	c.(805-807)GAG>GAT	p.E269D		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	269					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		TAACGAAGTCCTCCGGCTCAT	0.448													21	36					3.62473e-10	7.51907e-10	1	0	A	1742785	A	A	1742785	3	1	223	1	0	0	0	0	1	0	0	0	6523	680	24	4	327	4	GMDS	6	1742785	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08		1742785	169372282	65	40959											
KDM1B	221656	broad.mit.edu	37	chr6	18217997	18217997	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacaaagtattttgtcactCggtggagcacagacccatgg	11	9	10	11	1	1	1	1	0	0	1	2	2	1	2	2	3	1	2	2	3	2	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:18217997C>T	uc003nco.1	+	14	1732	c.1657C>T	c.(1657-1659)CGG>TGG	p.R553W	KDM1B_uc003ncn.1_Missense_Mutation_p.R524W|KDM1B_uc003ncp.1_Missense_Mutation_p.R109W|KDM1B_uc003ncq.1_Missense_Mutation_p.R109W	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	756					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						TTTTGTCACTCGGTGGAGCAC	0.418													32	39					0	0	0	0	T	18217997	T	T	18217997	3	4	223	1	0	0	0	0	1	0	0	0	8162	875	31	1	1628	1	KDM1B	6	18217997	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	16475212	18217997	152897070	66	40960											
C6orf62	81688	broad.mit.edu	37	chr6	24706378	24706378	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtactctactctggcataTaaggacggaggtgatcctct	10	11	10	10	1	3	1	0	1	3	0	4	3	4	3	1	4	2	2	1	4	4	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:24706378T>C	uc003nel.2	-	5	1184	c.677A>G	c.(676-678)TAT>TGT	p.Y226C		NM_030939	NP_112201	Q9GZU0	CF062_HUMAN	hypothetical protein LOC81688	226						intracellular					0						CTCTGGCATATAAGGACGGAG	0.443													25	21					0	0	0	0	C	24706378	C	C	24706378	3	2	223	1	0	0	0	0	1	0	0	0	2378	1406	49	5	16	5	C6orf62	6	24706378	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	6488381	24706378	146408689	67	40961											
SCGN	10590	broad.mit.edu	37	chr6	25701545	25701545	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gagctggctttgtgtcttggGctgaaaatcaacccataatc	10	12	10	9	0	2	1	1	1	1	0	3	2	2	1	1	2	2	3	1	2	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:25701545G>T	uc003nfb.2	+	11	1016	c.813G>T	c.(811-813)GGG>GGT	p.G271G	SCGN_uc010jpz.2_Silent_p.G162G	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	271	EF-hand 6.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						TGTGTCTTGGGCTGAAAATCA	0.463													24	34					7.87624e-14	1.6825e-13	1	0	T	25701545	T	T	25701545	2	4	223	1	0	0	0	0	0	0	0	1	13968	1190	42	4		4	SCGN	6	25701545	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	995167	25701545	145413522	68	40962											
HIST1H2AK	8330	broad.mit.edu	37	chr6	27805943	27805943	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccaggatctcggcggttaGgtactccaacaccgccgcca	8	8	10	15	4	1	0	0	0	1	0	4	1	3	1	5	4	2	2	5	4	3	3	rs144042626		TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:27805943G>C	uc003njs.2	-	1	175	c.175C>G	c.(175-177)CTA>GTA	p.L59V	HIST1H2BN_uc003njt.1_5'Flank|HIST1H2BN_uc003nju.1_5'Flank|HIST1H2BN_uc003njv.2_5'Flank	NM_003510	NP_003501	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	59					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			upper_aerodigestive_tract(1)	1						TCGGCGGTTAGGTACTCCAAC	0.667													12	91					0	0	0	0	C	27805943	C	C	27805943	3	2	223	1	0	0	0	0	1	0	0	0	7176	991	35	4	221	4	HIST1H2AK	6	27805943	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	2104398	27805943	143309124	69	40963											
TNXB	7148	broad.mit.edu	37	chr6	32020624	32020624	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtactgcacagtgaaggagtCgaagcggccctgggggatgg	9	6	18	8	2	0	1	0	1	0	0	1	4	0	3	1	5	3	2	1	5	3	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:32020624C>T	uc003nzl.2	-	26	9134	c.8932G>A	c.(8932-8934)GAC>AAC	p.D2978N		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3025	Fibronectin type-III 22.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GTGAAGGAGTCGAAGCGGCCC	0.701													29	20					0	0	0	0	T	32020624	T	T	32020624	3	4	223	1	0	0	0	0	1	0	0	0	16412	884	31	1	5857	1	TNXB	6	32020624	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	4214681	32020624	139094443	70	40964											
ENPP4	22875	broad.mit.edu	37	chr6	46107712	46107712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttcaggaaaacagatcaaGtgctgctgctatgtggcctg	10	10	12	9	0	2	1	2	0	0	1	2	2	2	2	1	2	4	4	1	2	4	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:46107712G>A	uc003oxy.2	+	2	651	c.392G>A	c.(391-393)AGT>AAT	p.S131N		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	131	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						AACAGATCAAGTGCTGCTGCT	0.413													37	54					0	0	0	0	A	46107712	A	A	46107712	3	1	223	1	0	0	0	0	1	0	0	0	5156	1029	36	4	394	4	ENPP4	6	46107712	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	14087088	46107712	125007355	71	40965											
KIAA1586	57691	broad.mit.edu	37	chr6	56917579	56917579	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagaaaataatgaagtgagCaaaaatcactgcagattgtc	19	8	8	6	0	1	4	1	2	0	2	2	4	1	4	0	0	2	2	0	0	6	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:56917579C>T	uc003pdj.2	+	4	452	c.282C>T	c.(280-282)AGC>AGT	p.S94S	KIAA1586_uc011dxm.1_Silent_p.S67S	NM_020931	NP_065982	Q9HCI6	K1586_HUMAN	hypothetical protein LOC57691	94							nucleic acid binding				0	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ATGAAGTGAGCAAAAATCACT	0.338													10	42					0	0	0	0	T	56917579	T	T	56917579	2	4	223	1	0	0	0	0	0	0	0	1	8284	709	25	4		4	KIAA1586	6	56917579	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	10809867	56917579	114197488	72	40966											
LGSN	51557	broad.mit.edu	37	chr6	63990178	63990178	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctatgaagtccatctaagccGgcagcaacagttgcagccag	12	7	10	12	1	1	1	0	1	1	0	2	1	2	1	3	1	5	4	3	1	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:63990178G>A	uc003peh.2	-	4	1312	c.1278C>T	c.(1276-1278)GCC>GCT	p.A426A	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	426					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	CATCTAAGCCGGCAGCAACAG	0.453													14	53					0	0	0	0	A	63990178	A	A	63990178	2	1	223	1	0	0	0	0	0	0	0	1	8800	1103	39	1		1	LGSN	6	63990178	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	7072599	63990178	107124889	73	40967											
HTR1E	3354	broad.mit.edu	37	chr6	87725635	87725635	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgggtgcgttttatatccccTtgactttgatactgattctc	6	18	8	9	1	1	3	0	3	1	0	3	3	2	3	2	1	2	1	2	1	3	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:87725635T>A	uc003pli.2	+	2	1286	c.583T>A	c.(583-585)TTG>ATG	p.L195M		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	195	Helical; Name=5; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TTATATCCCCTTGACTTTGAT	0.507													9	34					0	0	0	0	A	87725635	A	A	87725635	3	1	223	1	0	0	0	0	1	0	0	0	7478	1606	56	5	585	5	HTR1E	6	87725635	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	23735457	87725635	83389432	74	40968											
SIM1	6492	broad.mit.edu	37	chr6	100838914	100838914	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcggtcacctgattcactggCcgacccagggtctggagaac	8	8	12	13	2	3	2	2	1	1	1	4	4	3	2	3	4	1	0	3	4	1	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:100838914C>T	uc003pqj.3	-	11	1831	c.1624G>A	c.(1624-1626)GCC>ACC	p.A542T	SIM1_uc010kcu.2_Missense_Mutation_p.A542T	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	542	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GATTCACTGGCCGACCCAGGG	0.438													4	55					0	0	0	0	T	100838914	T	T	100838914	3	4	223	1	0	0	0	0	1	0	0	0	14388	739	26	4	680	4	SIM1	6	100838914	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	13113279	100838914	70276153	75	40969											
SLC16A10	117247	broad.mit.edu	37	chr6	111498539	111498558	+	Frame_Shift_Del	DEL	ATTGTCACTGCTGGCAGCAG	-	-																															gccttggactggtgaatggcAttgtcactgctggcagcagt																								rs116051634	by1000genomes	TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:111498539_111498558delATTGTCACTGCTGGCAGCAG	uc003pus.2	+	3	788_807	c.613_632delATTGTCACTGCTGGCAGCAG	c.(613-633)ATTGTCACTGCTGGCAGCAGTfs	p.I205fs	SLC16A10_uc003pur.3_Frame_Shift_Del_p.I205fs|SLC16A10_uc003put.2_5'UTR	NM_018593	NP_061063	Q8TF71	MOT10_HUMAN	solute carrier family 16, member 10	205_211	Helical; (Potential).				aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity				0		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		GGTGAATGGCATTGTCACTGCTGGCAGCAGTGTCTTCACA	0.482													---	---	---								-	111498558	-	-	111498539	7	5	223	1	0	1	0	1	0	0	0	0	14468	217	8	0	623	0	SLC16A10	6	111498539	Frame_Shift_Del	DEL	ATTGTCACTGCTGGCAGCAG	TCGA-CV-7101-01A-11D-2012-08	10659625	111498539	59616528	76	40970											
LAMA4	3910	broad.mit.edu	37	chr6	112510314	112510314	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgtactgttatttttacttAtggttgggcagtccatgcct	7	18	9	7	0	0	0	0	0	0	0	1	0	1	0	2	2	3	4	2	2	4	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:112510314A>G	uc003pvu.2	-	7	1121	c.812T>C	c.(811-813)ATA>ACA	p.I271T	LAMA4_uc003pvv.2_Intron|LAMA4_uc003pvt.2_Intron	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	271	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		ATTTTTACTTATGGTTGGGCA	0.468													4	21					0	0	0	0	G	112510314	G	G	112510314	3	3	223	1	0	0	0	0	1	0	0	0	8648	449	16	5	4791	5	LAMA4	6	112510314	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08	1011775	112510314	58604753	77	40971											
C6orf204	387119	broad.mit.edu	37	chr6	118887417	118887417	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agacggcatcacatgggcagTaggaagagtaatcaatgatt	15	8	12	6	1	2	3	2	1	0	2	2	4	2	4	0	3	0	4	0	3	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:118887417T>C	uc003pxz.1	-	3	883	c.295A>G	c.(295-297)ACT>GCT	p.T99A	C6orf204_uc003pya.1_Missense_Mutation_p.T102A|C6orf204_uc003pyb.2_Missense_Mutation_p.T99A|C6orf204_uc011ebj.1_5'UTR|C6orf204_uc003pyc.2_Missense_Mutation_p.T102A|C6orf204_uc011ebl.1_5'UTR	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	99						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		ACATGGGCAGTAGGAAGAGTA	0.383													6	27					0	0	0	0	C	118887417	C	C	118887417	3	2	223	1	0	0	0	0	1	0	0	0	2363	1638	57	5	2220	5	C6orf204	6	118887417	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	6377103	118887417	52227650	78	40972											
OLIG3	167826	broad.mit.edu	37	chr6	137815177	137815177	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctgcatcatatcgcccTgcgtggacgagaccgagttg	7	11	11	12	4	3	1	1	0	2	1	4	4	3	2	2	1	2	2	2	1	1	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:137815177T>C	uc003qhp.1	-	1	355	c.131A>G	c.(130-132)CAG>CGG	p.Q44R		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	44					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		CATATCGCCCTGCGTGGACGA	0.512													35	63					0	0	0	0	C	137815177	C	C	137815177	3	2	223	1	0	0	0	0	1	0	0	0	10916	1580	55	5	691	5	OLIG3	6	137815177	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	18927760	137815177	33299890	79	40973											
ECT2L	345930	broad.mit.edu	37	chr6	139167765	139167769	+	Frame_Shift_Del	DEL	CTCTC	-	-																															tgatgacagatcttcatatgCtctccggccacacttcatgt																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr6:139167765_139167769delCTCTC	uc003qif.1	+	6	957_961	c.854_858delCTCTC	c.(853-858)GCTCTCfs	p.A285fs	ECT2L_uc011edq.1_Frame_Shift_Del_p.A216fs	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	285_286					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TCTTCATATGCTCTCCGGCCACACT	0.376													---	---	---								-	139167769	-	-	139167765	7	5	223	1	0	1	0	1	0	0	0	0	4924	797	28	0	876	0	ECT2L	6	139167765	Frame_Shift_Del	DEL	CTCTC	TCGA-CV-7101-01A-11D-2012-08	1352588	139167765	31947302	80	40974											
CDCA7L	55536	broad.mit.edu	37	chr7	21947962	21947962	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagaactgtttttatctggtTtgttggccagcttcttggtg	6	18	11	6	0	2	1	0	0	2	1	2	1	2	1	1	3	2	4	1	3	3	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:21947962T>G	uc010kuk.2	-	4	587	c.467A>C	c.(466-468)AAA>ACA	p.K156T	CDCA7L_uc003sve.3_Missense_Mutation_p.K122T|CDCA7L_uc010kul.2_Missense_Mutation_p.K110T|CDCA7L_uc003svf.3_Missense_Mutation_p.K155T|CDCA7L_uc011jyk.1_Missense_Mutation_p.K156T	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	156					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						TTTATCTGGTTTGTTGGCCAG	0.423													4	59					0	0	0	0	G	21947962	G	G	21947962	3	3	223	1	0	0	0	0	1	0	0	0	3106	1841	64	5	925	5	CDCA7L	7	21947962	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08		21947962	137190701	81	40975											
STK31	56164	broad.mit.edu	37	chr7	23809341	23809341	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcctagagaagactgagtCaagtgtctgcaaagagctgg	14	8	12	7	0	2	4	1	1	1	3	3	5	3	4	1	1	2	2	1	1	5	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:23809341C>A	uc003sws.3	+	13	1746	c.1679C>A	c.(1678-1680)TCA>TAA	p.S560*	STK31_uc003swt.3_Nonsense_Mutation_p.S537*|STK31_uc011jze.1_Nonsense_Mutation_p.S560*|STK31_uc010kuq.2_Nonsense_Mutation_p.S537*	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	560							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						AAGACTGAGTCAAGTGTCTGC	0.378													36	96					3.21399e-22	7.04553e-22	1	0	A	23809341	A	A	23809341	4	1	223	1	0	0	0	0	0	1	0	0	15362	838	29	2	1729	2	STK31	7	23809341	Nonsense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	1861379	23809341	135329322	82	40976											
HECW1	23072	broad.mit.edu	37	chr7	43590145	43590145	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaagtggcgggtggagcgCggcgtggtacagcagaccga	8	5	20	8	5	0	2	0	1	0	1	0	4	0	3	1	5	3	2	1	5	2	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:43590145C>T	uc003tid.1	+	27	4955	c.4350C>T	c.(4348-4350)CGC>CGT	p.R1450R	HECW1_uc011kbi.1_Silent_p.R1416R	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1450	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GGGTGGAGCGCGGCGTGGTAC	0.627													8	6					0	0	0	0	T	43590145	T	T	43590145	2	4	223	1	0	0	0	0	0	0	0	1	7081	755	27	1		1	HECW1	7	43590145	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	19780804	43590145	115548518	83	40977											
YWHAG	7532	broad.mit.edu	37	chr7	75990616	75990617	+	5'Flank	INS	-	A	A																															acagaaaaagactccgtctcINSaaaaaaaaaaaaaaaaaaag																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	44de281e-3382-4bfc-a40b-45f8797b9570	g.chr7:75990616_75990617insA	uc011kgj.1	-							NM_012479	NP_036611	P61981	1433G_HUMAN	tyrosine 3-monooxygenase/tryptophan						G2/M transition of mitotic cell cycle|regulation of neuron differentiation|regulation of signal transduction|regulation of synaptic plasticity	cytosol	insulin-like growth factor receptor binding|protein kinase C binding|protein kinase C inhibitor activity			ovary(1)|lung(1)	2						gactccgtctcaaaaaaaaaaa	0.243													---	---	---								A	75990617	A	A	75990616	6	5	223	0	1	1	1	0	0	0	0	0	17571	841	29	0		0	YWHAG	7	75990616	5'Flank	INS	-	TCGA-CV-7101-01A-11D-2012-08	32400471	75990616	83148047	84	40978											
SEMA3C	10512	broad.mit.edu	37	chr7	80432017	80432017	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtttctgggccgtcttcatCtgttaccgagcacaccagcc	6	12	9	14	2	4	0	1	0	3	0	4	1	4	0	4	1	3	3	4	1	1	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:80432017C>T	uc003uhj.2	-	9	1442	c.880G>A	c.(880-882)GAT>AAT	p.D294N	SEMA3C_uc011kgw.1_Missense_Mutation_p.D312N|SEMA3C_uc011kgx.1_Missense_Mutation_p.D146N	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	294	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						CCGTCTTCATCTGTTACCGAG	0.383													6	69					0	0	0	0	T	80432017	T	T	80432017	3	4	223	1	0	0	0	0	1	0	0	0	14091	913	32	2	1415	2	SEMA3C	7	80432017	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	4441401	80432017	78706646	85	40979											
PCLO	27445	broad.mit.edu	37	chr7	82784624	82784624	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctggaatctttcctggccCaggctgctgaactggagtct	7	11	12	11	0	2	1	0	1	2	0	3	3	3	3	2	4	3	3	2	4	2	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:82784624C>A	uc003uhx.2	-	2	1622	c.1333G>T	c.(1333-1335)GGG>TGG	p.G445W	PCLO_uc003uhv.2_Missense_Mutation_p.G445W	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	396	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTCCTGGCCCAGGCTGCTGA	0.577													46	87					1.8453e-21	4.02756e-21	1	0	A	82784624	A	A	82784624	3	1	223	1	0	0	0	0	1	0	0	0	11637	594	21	4	14208	4	PCLO	7	82784624	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	2352607	82784624	76354039	86	40980											
AKAP9	10142	broad.mit.edu	37	chr7	91691800	91691800	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcaggcccagttgaacaaCgtaagtattttcagaatttg	13	11	10	7	1	1	2	1	1	0	1	1	2	1	2	1	2	2	4	1	2	5	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:91691800C>T	uc003ulg.2	+	24	6202	c.5977C>T	c.(5977-5979)CAA>TAA	p.Q1993*	AKAP9_uc003ulf.2_Nonsense_Mutation_p.Q1993*|AKAP9_uc003uli.2_Nonsense_Mutation_p.Q1616*	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2005	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGTTGAACAACGTAAGTATTT	0.393			T	BRAF	papillary thyroid								5	56					0	0	0	0	T	91691800	T	T	91691800	4	4	223	1	0	0	0	0	0	1	0	0	459	550	19	1	6071	1	AKAP9	7	91691800	Nonsense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	8907176	91691800	67446863	87	40981											
COL1A2	1278	broad.mit.edu	37	chr7	94054509	94054509	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgggtagtcctggagtcaaCggtgctcctggtgaagctgg	6	10	17	8	1	1	1	1	1	0	0	3	2	3	2	2	5	3	3	2	5	3	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:94054509C>T	uc003ung.1	+	42	3225	c.2754C>T	c.(2752-2754)AAC>AAT	p.N918N	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	918					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CTGGAGTCAACGGTGCTCCTG	0.522										HNSCC(75;0.22)			4	43					0	0	0	0	T	94054509	T	T	94054509	2	4	223	1	0	0	0	0	0	0	0	1	3693	535	19	1		1	COL1A2	7	94054509	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	2362709	94054509	65084154	88	40982											
TRRAP	8295	broad.mit.edu	37	chr7	98567840	98567840	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctggccgatagccacgacCgtgccgccttcgccatggtc	6	7	11	17	5	0	0	0	0	0	0	2	2	0	0	7	2	2	0	7	2	1	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:98567840C>T	uc003upp.2	+	51	7806	c.7597C>T	c.(7597-7599)CGT>TGT	p.R2533C	TRRAP_uc011kis.1_Missense_Mutation_p.R2515C|TRRAP_uc003upr.2_Missense_Mutation_p.R2232C	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2533					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TAGCCACGACCGTGCCGCCTT	0.632													22	74					0	0	0	0	T	98567840	T	T	98567840	3	4	223	1	0	0	0	0	1	0	0	0	16668	652	23	1	7737	1	TRRAP	7	98567840	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	4513331	98567840	60570823	89	40983											
ZKSCAN5	23660	broad.mit.edu	37	chr7	99128782	99128782	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtgttaagaagaaaatttCagaatattcagaagcagaca	20	9	8	4	0	2	5	2	0	0	5	2	5	2	5	0	0	1	2	0	0	8	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:99128782C>G	uc003uqv.2	+	7	1554	c.1430C>G	c.(1429-1431)TCA>TGA	p.S477*	ZKSCAN5_uc010lfx.2_Nonsense_Mutation_p.S477*|ZKSCAN5_uc003uqw.2_Nonsense_Mutation_p.S477*|ZKSCAN5_uc003uqx.2_Nonsense_Mutation_p.S404*|ZKSCAN5_uc003uqy.2_Nonsense_Mutation_p.S213*	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	477					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AAGAAAATTTCAGAATATTCA	0.318													11	145					0	0	0	0	G	99128782	G	G	99128782	4	3	223	1	0	0	0	0	0	1	0	0	17757	838	29	2	1452	2	ZKSCAN5	7	99128782	Nonsense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	560942	99128782	60009881	90	40984											
ACHE	43	broad.mit.edu	37	chr7	100491265	100491265	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acccacattgcccggggcctCtcggctccccggcagggcca	5	5	12	19	3	1	0	0	0	1	0	3	0	2	0	6	5	1	2	6	5	0	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:100491265C>G	uc003uxd.2	-	1	745	c.589G>C	c.(589-591)GAG>CAG	p.E197Q	ACHE_uc003uxe.2_Missense_Mutation_p.E197Q|ACHE_uc003uxf.2_Missense_Mutation_p.E197Q|ACHE_uc003uxg.2_Missense_Mutation_p.E197Q|ACHE_uc003uxh.2_Missense_Mutation_p.E197Q|ACHE_uc003uxi.2_Missense_Mutation_p.E197Q|ACHE_uc003uxj.1_Missense_Mutation_p.E316Q	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	197					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	CCCGGGGCCTCTCGGCTCCCC	0.652													20	86					0	0	0	0	G	100491265	G	G	100491265	3	3	223	1	0	0	0	0	1	0	0	0	141	922	32	2	1406	2	ACHE	7	100491265	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	1362483	100491265	58647398	91	40985											
RAB19	401409	broad.mit.edu	37	chr7	140125753	140125753	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcacactggctgagaagtacGgcctcctggccgttttggag	7	9	14	11	2	0	1	0	1	0	1	1	3	1	2	3	4	1	4	3	4	2	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:140125753G>T	uc010lni.2	+	4	655	c.457G>T	c.(457-459)GGC>TGC	p.G153C	RAB19_uc011krc.1_Missense_Mutation_p.G153C	NM_001008749	NP_001008749	A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	153					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0	Melanoma(164;0.0142)					TGAGAAGTACGGCCTCCTGGC	0.522													42	87					1.62957e-23	3.60372e-23	1	0	T	140125753	T	T	140125753	3	4	223	1	0	0	0	0	1	0	0	0	12969	1116	39	3	467	3	RAB19	7	140125753	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	39634488	140125753	19012910	92	40986											
DPP6	1804	broad.mit.edu	37	chr7	154561126	154561126	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctactctgttttcccttaGaggagattttgaagacacac	10	14	7	10	0	2	4	0	1	2	3	3	5	3	4	1	1	1	1	1	1	3	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr7:154561126G>C	uc003wlk.2	+	9	1013	c.884_splice	c.e9-1	p.E295_splice	DPP6_uc003wli.2_Splice_Site_p.E231_splice|DPP6_uc003wlm.2_Splice_Site_p.E233_splice|DPP6_uc011kvq.1_Splice_Site_p.E188_splice	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1						cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TTTTCCCTTAGAGGAGATTTT	0.512													8	71					0	0	0	0	C	154561126	C	C	154561126	5	2	223	1	0	0	0	0	0	0	1	0	4752	956	33	2	1033	2	DPP6	7	154561126	Splice_Site	SNP	G	TCGA-CV-7101-01A-11D-2012-08	14435373	154561126	4577537	93	40987											
CLN8	2055	broad.mit.edu	37	chr8	1719415	1719415	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agagagaaggtcttctgggaCctggcggccacgcgtgcagt	8	7	16	10	3	2	2	0	0	2	2	2	4	2	3	2	4	1	1	2	4	1	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:1719415C>T	uc003wpo.3	+	2	500	c.195C>T	c.(193-195)GAC>GAT	p.D65D		NM_018941	NP_061764	Q9UBY8	CLN8_HUMAN	ceroid-lipofuscinosis, neuronal 8	65	TLC.|Helical; (Potential).				cell death|ceramide biosynthetic process|cholesterol metabolic process|lipid transport|negative regulation of proteolysis|phospholipid metabolic process	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.67e-05)|READ - Rectum adenocarcinoma(644;0.0913)		TCTTCTGGGACCTGGCGGCCA	0.612													11	42					0	0	0	0	T	1719415	T	T	1719415	2	4	223	1	0	0	0	0	0	0	0	1	3561	506	18	4		4	CLN8	8	1719415	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08		1719415	144644607	94	40988											
MYOM2	9172	broad.mit.edu	37	chr8	2044180	2044180	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgaaattcagtggtggctCgcccatcctgggctactacc	7	9	10	15	2	1	0	1	0	0	0	3	1	2	0	4	3	2	2	4	3	3	3	rs149624495	byFrequency	TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:2044180C>T	uc003wpx.3	+	18	2357	c.2219C>T	c.(2218-2220)TCG>TTG	p.S740L	MYOM2_uc011kwi.1_Missense_Mutation_p.S165L	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	740	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AGTGGTGGCTCGCCCATCCTG	0.557													36	46					0	0	0	0	T	2044180	T	T	2044180	3	4	223	1	0	0	0	0	1	0	0	0	10145	893	31	1	2285	1	MYOM2	8	2044180	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	324765	2044180	144319842	95	40989											
CSMD1	64478	broad.mit.edu	37	chr8	4494992	4494992	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccgtgatgatgatccaggtGcagttggcatagttcggata	9	11	13	8	2	0	3	0	3	0	0	2	4	1	4	2	3	1	4	2	3	2	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:4494992G>A	uc011kwk.1	-	2	564	c.174C>T	c.(172-174)TGC>TGT	p.C58C		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	58	Extracellular (Potential).|CUB 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGATCCAGGTGCAGTTGGCAT	0.478													5	79					0	0	0	0	A	4494992	A	A	4494992	2	1	223	1	0	0	0	0	0	0	0	1	3961	1311	46	4		4	CSMD1	8	4494992	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	2450812	4494992	141869030	96	40990											
SLC18A1	6570	broad.mit.edu	37	chr8	20008242	20008242	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtaggacacactggcaggCaagaaagctagacctgtgga	14	5	14	8	0	0	2	0	0	0	2	0	4	0	4	1	5	1	4	1	5	4	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:20008242C>A	uc011kyq.1	-	12	1500	c.1029G>T	c.(1027-1029)TTG>TTT	p.L343F	SLC18A1_uc003wzl.2_Missense_Mutation_p.L130F|SLC18A1_uc003wzm.2_Missense_Mutation_p.L343F|SLC18A1_uc011kyr.1_Missense_Mutation_p.L343F|SLC18A1_uc003wzn.2_Missense_Mutation_p.L311F|SLC18A1_uc010ltf.2_RNA|SLC18A1_uc003wzo.2_Missense_Mutation_p.L311F	NM_001135691	NP_001129163	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine),	343	Helical; (Potential).				neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			ovary(2)	2				Colorectal(74;0.0747)		CACTGGCAGGCAAGAAAGCTA	0.498													20	70					1.56452e-12	3.29996e-12	1	0	A	20008242	A	A	20008242	3	1	223	1	0	0	0	0	1	0	0	0	14490	709	25	4	572	4	SLC18A1	8	20008242	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	15513250	20008242	126355780	97	40991											
ENTPD4	9583	broad.mit.edu	37	chr8	23302048	23302048	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgcccgtggcacatgctCtgcagcaaagttcaaaagtg	10	11	10	10	1	2	0	1	0	1	0	2	0	2	0	1	1	4	5	1	1	3	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:23302048C>G	uc003xdl.2	-	5	648	c.484G>C	c.(484-486)GAG>CAG	p.E162Q	ENTPD4_uc011kzu.1_Missense_Mutation_p.E162Q|ENTPD4_uc003xdm.2_Missense_Mutation_p.E162Q|ENTPD4_uc011kzv.1_Missense_Mutation_p.E162Q|ENTPD4_uc011kzw.1_Missense_Mutation_p.E128Q	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	162	Lumenal (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		GGCACATGCTCTGCAGCAAAG	0.453													4	68					0	0	0	0	G	23302048	G	G	23302048	3	3	223	1	0	0	0	0	1	0	0	0	5165	922	32	2	1402	2	ENTPD4	8	23302048	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	3293806	23302048	123061974	98	40992											
STAR	6770	broad.mit.edu	37	chr8	38005823	38005823	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccagctcctggtcactgtaGagagtctcttctagccgaga	8	10	11	12	1	3	2	1	0	2	2	5	4	4	2	3	1	2	2	3	1	2	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:38005823G>C	uc003xkv.1	-	3	465	c.201C>G	c.(199-201)CTC>CTG	p.L67L	STAR_uc010lwc.1_Silent_p.L29L	NM_001007243	NP_001007244	P49675	STAR_HUMAN	steroidogenic acute regulatory protein isoform	67	START.				C21-steroid hormone biosynthetic process	mitochondrial intermembrane space	cholesterol transporter activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.0151)|Lung NSC(58;0.0295)		READ - Rectum adenocarcinoma(644;0.188)		GGTCACTGTAGAGAGTCTCTT	0.582													3	24					0	0	0	0	C	38005823	C	C	38005823	2	2	223	1	0	0	0	0	0	0	0	1	15320	929	33	2		2	STAR	8	38005823	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	14703775	38005823	108358199	99	40993											
BAG4	9530	broad.mit.edu	37	chr8	38066593	38066593	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcgtagtgttccacaatcAggaccgactgtacgaccaca	13	8	8	12	3	1	0	1	0	0	0	3	3	2	1	3	1	1	3	3	1	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:38066593A>G	uc003xky.1	+	4	978	c.696A>G	c.(694-696)TCA>TCG	p.S232S	BAG4_uc003xkz.1_Silent_p.S196S	NM_004874	NP_004865	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	232					anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				TTCCACAATCAGGACCGACTG	0.498													6	26					0	0	0	0	G	38066593	G	G	38066593	2	3	223	1	0	0	0	0	0	0	0	1	1291	175	7	5		5	BAG4	8	38066593	Silent	SNP	A	TCGA-CV-7101-01A-11D-2012-08	60770	38066593	108297429	100	40994											
YTHDF3	253943	broad.mit.edu	37	chr8	64099527	64099527	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgcaaagccaactgcctCaacagcagcctcaaccacca	13	5	7	16	0	2	0	2	0	0	0	2	0	2	0	5	1	8	2	5	1	4	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:64099527C>T	uc003xuy.2	+	5	1274	c.958C>T	c.(958-960)CAA>TAA	p.Q320*	YTHDF3_uc010lys.2_Nonsense_Mutation_p.Q264*|YTHDF3_uc003xuz.2_Nonsense_Mutation_p.Q264*|YTHDF3_uc003xva.2_Nonsense_Mutation_p.Q264*|YTHDF3_uc011len.1_Nonsense_Mutation_p.Q264*	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	320											0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			CCAACTGCCTCAACAGCAGCC	0.547													8	24					0	0	0	0	T	64099527	T	T	64099527	4	4	223	1	0	0	0	0	0	1	0	0	17568	813	29	2	971	2	YTHDF3	8	64099527	Nonsense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	26032934	64099527	82264495	101	40995											
CSMD3	114788	broad.mit.edu	37	chr8	113585856	113585856	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagtaaaagcacctagtaGatgagtcgttttatcttttc	12	14	7	8	1	1	2	0	1	1	1	3	2	1	2	2	0	1	4	2	0	5	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:113585856G>A	uc003ynu.2	-	24	4075	c.3916C>T	c.(3916-3918)CTA>TTA	p.L1306L	CSMD3_uc003yns.2_Silent_p.L578L|CSMD3_uc003ynt.2_Silent_p.L1266L|CSMD3_uc011lhx.1_Silent_p.L1202L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1306	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GCACCTAGTAGATGAGTCGTT	0.333										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	43					0	0	0	0	A	113585856	A	A	113585856	2	1	223	1	0	0	0	0	0	0	0	1	3963	933	33	2		2	CSMD3	8	113585856	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	49486329	113585856	32778166	102	40996											
COL14A1	7373	broad.mit.edu	37	chr8	121282288	121282288	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcagtatgtaaggcggccAaggctgacctggtatttatg	9	12	12	8	1	1	1	1	1	0	0	1	1	1	1	2	4	0	4	2	4	5	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:121282288A>G	uc003yox.2	+	26	3353	c.3088A>G	c.(3088-3090)AAG>GAG	p.K1030E	COL14A1_uc003yoz.2_5'UTR	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1030					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TAAGGCGGCCAAGGCTGACCT	0.403													5	55					0	0	0	0	G	121282288	G	G	121282288	3	3	223	1	0	0	0	0	1	0	0	0	3686	131	5	5	3186	5	COL14A1	8	121282288	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08	7696432	121282288	25081734	103	40997											
TRMT12	55039	broad.mit.edu	37	chr8	125463521	125463521	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtcgctgggtggagggtcGgggagtcaagtggtcagccg	6	7	21	7	3	2	0	2	0	0	0	4	3	2	2	1	6	1	1	1	6	1	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:125463521G>T	uc003yra.3	+	1	474	c.353G>T	c.(352-354)CGG>CTG	p.R118L		NM_017956	NP_060426	Q53H54	TYW2_HUMAN	homolog of yeast tRNA methyltransferase 12	118					tRNA processing		methyltransferase activity			upper_aerodigestive_tract(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GTGGAGGGTCGGGGAGTCAAG	0.557													5	94					0.00116845	0.00220511	1	0	T	125463521	T	T	125463521	3	4	223	1	0	0	0	0	1	0	0	0	16631	1116	39	3	355	3	TRMT12	8	125463521	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	4181233	125463521	20900501	104	40998											
KHDRBS3	10656	broad.mit.edu	37	chr8	136594129	136594129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcttggttacaggggaagggGaggagttacagcccggccag	9	7	17	8	1	1	0	0	0	1	0	1	3	1	3	2	7	3	2	2	7	3	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr8:136594129G>A	uc003yuv.2	+	6	1014	c.620G>A	c.(619-621)GGA>GAA	p.G207E	KHDRBS3_uc003yuw.2_Missense_Mutation_p.G207E|KHDRBS3_uc010mek.2_RNA	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	207					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			AGGGGAAGGGGAGGAGTTACA	0.483													25	72					0	0	0	0	A	136594129	A	A	136594129	3	1	223	1	0	0	0	0	1	0	0	0	8187	1174	41	2	642	2	KHDRBS3	8	136594129	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	11130608	136594129	9769893	105	40999											
MPDZ	8777	broad.mit.edu	37	chr9	13216781	13216781	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgtaacttactgctataaTttggtctccaatttggattc	9	18	7	7	0	1	0	0	0	1	0	3	1	1	1	1	2	3	2	1	2	5	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:13216781T>C	uc010mia.1	-	9	1339	c.1282A>G	c.(1282-1284)ATT>GTT	p.I428V	MPDZ_uc010mhy.2_Missense_Mutation_p.I428V|MPDZ_uc010mhz.2_Missense_Mutation_p.I428V|MPDZ_uc011lmn.1_Missense_Mutation_p.I428V|MPDZ_uc003zlb.3_Missense_Mutation_p.I428V	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	428	PDZ 3.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		ACTGCTATAATTTGGTCTCCA	0.323													10	12					0	0	0	0	C	13216781	C	C	13216781	3	2	223	1	0	0	0	0	1	0	0	0	9775	1493	52	5	4991	5	MPDZ	9	13216781	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08		13216781	127996650	106	41000											
CDKN2A	1029	broad.mit.edu	37	chr9	21971028	21971028	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggtccacgggcagacggccCcaggcatcgcgcacgtccag	8	3	14	16	5	0	1	0	0	0	1	3	1	2	1	4	4	0	3	4	4	0	0	rs121913389		TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:21971028C>T	uc003zpk.2	-	2	542	c.330G>A	c.(328-330)TGG>TGA	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.G166R	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGACGGCCCCAGGCATCGC	0.736		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			11	15					0	0	0	0	T	21971028	T	T	21971028	4	4	223	1	0	0	0	0	0	1	0	0	3176	624	22	4	148	4	CDKN2A	9	21971028	Nonsense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	8754247	21971028	119242403	107	41001											
UBAP2	55833	broad.mit.edu	37	chr9	33927875	33927875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccagacagaggctgttcgcgGtgttcatgctactggacagg	8	9	14	10	2	1	2	1	0	0	2	2	3	1	3	1	4	2	4	1	4	1	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:33927875G>A	uc003ztq.1	-	20	2404	c.2291C>T	c.(2290-2292)ACC>ATC	p.T764I	UBAP2_uc011loc.1_Missense_Mutation_p.T673I|UBAP2_uc011lod.1_Missense_Mutation_p.T497I|UBAP2_uc011loe.1_Missense_Mutation_p.T519I|UBAP2_uc011lof.1_Missense_Mutation_p.T689I|UBAP2_uc011log.1_3'UTR|UBAP2_uc003ztn.1_Missense_Mutation_p.T3I|UBAP2_uc003zto.1_Missense_Mutation_p.T3I|UBAP2_uc003ztp.1_Missense_Mutation_p.T3I	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	764										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GCTGTTCGCGGTGTTCATGCT	0.637													30	44					0	0	0	0	A	33927875	A	A	33927875	3	1	223	1	0	0	0	0	1	0	0	0	16905	1261	44	4	1108	4	UBAP2	9	33927875	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	11956847	33927875	107285556	108	41002											
KIF24	347240	broad.mit.edu	37	chr9	34310897	34310897	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcattcagaattcctgtttTtgtatggtactgggaatcat	9	16	10	6	0	2	1	2	0	0	1	3	2	3	2	1	3	1	4	1	3	4	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:34310897T>C	uc003zua.3	-	2	568	c.448A>G	c.(448-450)AAA>GAA	p.K150E	KIF24_uc010mkb.2_Missense_Mutation_p.K181E	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	150					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			ATTCCTGTTTTTGTATGGTAC	0.403													28	124					0	0	0	0	C	34310897	C	C	34310897	3	2	223	1	0	0	0	0	1	0	0	0	8331	1850	64	5	3706	5	KIF24	9	34310897	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	383022	34310897	106902534	109	41003											
S1PR3	1903	broad.mit.edu	37	chr9	91617076	91617076	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaactgcctggtcaggggaCggggggcccgcgcctcaccc	5	4	16	16	3	2	0	2	0	0	0	2	1	2	1	4	6	2	1	4	6	1	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:91617076C>T	uc004aqe.2	+	2	1357	c.961C>T	c.(961-963)CGG>TGG	p.R321W		NM_005226	NP_005217	Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	321	Cytoplasmic (By similarity).				anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)|central_nervous_system(1)|skin(1)	5						GGTCAGGGGACGGGGGGCCCG	0.612													19	29					0	0	0	0	T	91617076	T	T	91617076	3	4	223	1	0	0	0	0	1	0	0	0	13860	527	19	1	963	1	S1PR3	9	91617076	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	57306179	91617076	49596355	110	41004											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112900082	112900082	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaattcactggctgatttttCtctgccccagacaccacaaa	12	11	5	13	0	2	2	1	1	1	1	3	2	2	2	3	1	1	1	3	1	2	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:112900082C>G	uc004bei.2	+	9	3146	c.2954C>G	c.(2953-2955)TCT>TGT	p.S985C	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.S753C|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.S753C|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.S563C|AKAP2_uc011lwi.1_Missense_Mutation_p.S611C|AKAP2_uc004bem.2_Missense_Mutation_p.S611C|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.S571C|AKAP2_uc011lwj.1_Missense_Mutation_p.S522C|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.S522C	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	522							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						GCTGATTTTTCTCTGCCCCAG	0.507													6	101					0	0	0	0	G	112900082	G	G	112900082	3	3	223	1	0	0	0	0	1	0	0	0	11464	913	32	2	2288	2	PALM2-AKAP2	9	112900082	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	21283006	112900082	28313349	111	41005											
ZNF618	114991	broad.mit.edu	37	chr9	116810994	116810994	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcggcagaacatcgcagAgcggctgttgagggtcatgt	9	7	17	8	3	1	3	1	1	0	2	2	4	1	4	0	4	3	4	0	4	1	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:116810994A>G	uc004bid.2	+	15	1511	c.1412A>G	c.(1411-1413)GAG>GGG	p.E471G	ZNF618_uc004bic.2_Missense_Mutation_p.E378G|ZNF618_uc011lxi.1_Missense_Mutation_p.E438G|ZNF618_uc011lxj.1_Missense_Mutation_p.E439G|ZNF618_uc010mvb.2_Missense_Mutation_p.E61G	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	471					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AACATCGCAGAGCGGCTGTTG	0.557													25	63					0	0	0	0	G	116810994	G	G	116810994	3	3	223	1	0	0	0	0	1	0	0	0	18109	304	11	5	1187	5	ZNF618	9	116810994	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08	3910912	116810994	24402437	112	41006											
ASTN2	23245	broad.mit.edu	37	chr9	119495733	119495733	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaccccccggcactgctcCtccaccggcagcgggatcac	7	4	11	19	3	1	0	1	0	0	0	3	2	3	2	6	4	2	3	6	4	0	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:119495733C>T	uc004bjs.1	-	14	2567	c.2466G>A	c.(2464-2466)GAG>GAA	p.E822E	ASTN2_uc004bjr.1_Silent_p.E818E|ASTN2_uc004bjt.1_Silent_p.E771E	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	822	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GGCACTGCTCCTCCACCGGCA	0.602													33	84					0	0	0	0	T	119495733	T	T	119495733	2	4	223	1	0	0	0	0	0	0	0	1	1067	680	24	4		4	ASTN2	9	119495733	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	2684739	119495733	21717698	113	41007											
CRB2	286204	broad.mit.edu	37	chr9	126132410	126132410	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgacatgtgaggaagatgtgGatgaatgcctgtcggatccc	10	9	14	8	2	0	3	0	2	0	1	2	7	1	6	2	3	1	0	2	3	2	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:126132410G>A	uc004bnx.1	+	7	1170	c.1078G>A	c.(1078-1080)GAT>AAT	p.D360N	CRB2_uc004bnw.1_Missense_Mutation_p.D360N	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	360	Extracellular (Potential).|EGF-like 8; calcium-binding (Potential).					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						GGAAGATGTGGATGAATGCCT	0.572													23	75					0	0	0	0	A	126132410	A	A	126132410	3	1	223	1	0	0	0	0	1	0	0	0	3864	1174	41	2	1104	2	CRB2	9	126132410	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	6636677	126132410	15081021	114	41008											
NUP214	8021	broad.mit.edu	37	chr9	134073597	134073597	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggctaccccagccaccacGggggtccctgatgccaggac	8	4	13	16	1	0	1	0	1	0	0	1	3	1	2	6	4	3	1	6	4	1	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:134073597G>T	uc004cag.2	+	29	4827	c.4716G>T	c.(4714-4716)ACG>ACT	p.T1572T	NUP214_uc004cah.2_Silent_p.T1562T|NUP214_uc004cai.2_Silent_p.T1002T|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Silent_p.T398T|NUP214_uc011mcf.1_Silent_p.T349T|NUP214_uc010mzh.1_Silent_p.T86T|NUP214_uc010mzi.1_Silent_p.T86T	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1572	Pro/Ser/Thr-rich.|11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		CAGCCACCACGGGGGTCCCTG	0.577			T	DEK|SET|ABL1	AML|T-ALL								6	113					0.00116845	0.00220511	1	0	T	134073597	T	T	134073597	2	4	223	1	0	0	0	0	0	0	0	1	10816	1103	39	3		3	NUP214	9	134073597	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	7941187	134073597	7139834	115	41009											
COL5A1	1289	broad.mit.edu	37	chr9	137593123	137593123	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagcgaccaccccatgatcGacatcaatggcatcatcgtg	11	7	9	14	3	2	1	2	1	0	0	4	3	2	1	3	1	1	2	3	1	1	0	rs142890619	byFrequency	TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:137593123G>A	uc004cfe.2	+	4	980	c.598G>A	c.(598-600)GAC>AAC	p.D200N		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	200	TSP N-terminal.|Laminin G-like.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCCCATGATCGACATCAATGG	0.542													4	22					0	0	0	0	A	137593123	A	A	137593123	3	1	223	1	0	0	0	0	1	0	0	0	3711	1058	37	1	612	1	COL5A1	9	137593123	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	3519526	137593123	3620308	116	41010											
NOTCH1	4851	broad.mit.edu	37	chr9	139393659	139393659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccaggatcagtggcgtcGtgccatcatgcatgcgggca	8	7	14	12	3	2	0	2	0	0	0	3	1	2	1	2	3	4	2	2	3	0	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr9:139393659G>A	uc004chz.2	-	32	5987	c.5987C>T	c.(5986-5988)ACG>ATG	p.T1996M		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1996	ANK 3.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.T1997M(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CAGTGGCGTCGTGCCATCATG	0.647			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			6	51					0	0	0	0	A	139393659	A	A	139393659	3	1	223	1	0	0	0	0	1	0	0	0	10601	1145	40	1	1692	1	NOTCH1	9	139393659	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	1800536	139393659	1819772	117	41011											
CUBN	8029	broad.mit.edu	37	chr10	17127720	17127720	+	Frame_Shift_Del	DEL	C	-	-																															gagaaagtggtgcagaacttCccaagaagggggtcctgata																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr10:17127720delC	uc001ioo.2	-	16	2038	c.1986delG	c.(1984-1986)GGGfs	p.G662fs		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	662	CUB 2.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGCAGAACTTCCCAAGAAGGG	0.458													---	---	---								-	17127720	-	-	17127720	7	5	223	1	0	1	0	1	0	0	0	0	4068	842	30	0	9093	0	CUBN	10	17127720	Frame_Shift_Del	DEL	C	TCGA-CV-7101-01A-11D-2012-08		17127720	118407027	118	41012											
MYO3A	53904	broad.mit.edu	37	chr10	26243891	26243891	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagattctatgggatatactTtaagaaggataaagtaaatg	17	12	9	3	0	1	2	0	0	1	2	1	4	1	4	0	2	1	1	0	2	9	8			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr10:26243891T>A	uc001isn.2	+	4	617	c.257T>A	c.(256-258)TTT>TAT	p.F86Y	MYO3A_uc009xko.1_Missense_Mutation_p.F86Y|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.F86Y|MYO3A_uc001ism.2_Missense_Mutation_p.F86Y	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	86	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GGGATATACTTTAAGAAGGAT	0.373													6	82					0	0	0	0	A	26243891	A	A	26243891	3	1	223	1	0	0	0	0	1	0	0	0	10129	1841	64	5	263	5	MYO3A	10	26243891	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	9116171	26243891	109290856	119	41013											
ZEB1	6935	broad.mit.edu	37	chr10	31810429	31810429	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacagggttacttgtacacAgctgagggtgcacaagaaga	14	7	12	8	0	0	3	0	1	0	2	0	3	0	3	0	2	4	4	0	2	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr10:31810429A>G	uc001ivs.3	+	7	2229	c.2166A>G	c.(2164-2166)ACA>ACG	p.T722T	ZEB1_uc001ivr.3_Silent_p.T504T|ZEB1_uc010qee.1_Silent_p.T504T|ZEB1_uc010qef.1_Silent_p.T504T|ZEB1_uc009xlj.1_Silent_p.T648T|ZEB1_uc010qeg.1_Silent_p.T581T|ZEB1_uc009xlk.1_Silent_p.T504T|ZEB1_uc001ivt.3_Silent_p.T504T|ZEB1_uc001ivu.3_Silent_p.T723T|ZEB1_uc001ivv.3_Silent_p.T702T|ZEB1_uc010qeh.1_Silent_p.T655T|ZEB1_uc009xlo.1_Silent_p.T705T|ZEB1_uc009xlp.2_Silent_p.T706T	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	722					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				ACTTGTACACAGCTGAGGGTG	0.438													7	41					0	0	0	0	G	31810429	G	G	31810429	2	3	223	1	0	0	0	0	0	0	0	1	17690	175	7	5		5	ZEB1	10	31810429	Silent	SNP	A	TCGA-CV-7101-01A-11D-2012-08	5566538	31810429	103724318	120	41014											
DKK1	22943	broad.mit.edu	37	chr10	54074846	54074846	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgggaattactgcaaaaatgGtgagtcctgaaagctccctt	12	10	10	9	1	0	2	0	2	0	0	2	3	2	3	2	2	3	2	2	2	5	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr10:54074846G>T	uc001jjr.2	+	2	560	c.406_splice	c.e2+1	p.G136_splice	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor						negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TGCAAAAATGGTGAGTCCTGA	0.587													6	37					3.59834e-05	7.08378e-05	1	0	T	54074846	T	T	54074846	5	4	223	1	0	0	0	0	0	0	1	0	4566	1275	44	4	413	4	DKK1	10	54074846	Splice_Site	SNP	G	TCGA-CV-7101-01A-11D-2012-08	22264417	54074846	81459901	121	41015											
EGR2	1959	broad.mit.edu	37	chr10	64573002	64573003	+	Frame_Shift_Del	DEL	GC	-	-																															ccgagaggagcaaggggcgaGcggccctccgccaagactgc																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr10:64573002_64573003delGC	uc010qim.1	-	3	1549_1550	c.1395_1396delGC	c.(1393-1398)CCGCTCfs	p.P465fs	EGR2_uc010qin.1_Frame_Shift_Del_p.P415fs|EGR2_uc001jmi.2_Frame_Shift_Del_p.P465fs|EGR2_uc010qio.1_Frame_Shift_Del_p.P478fs|EGR2_uc009xph.2_Frame_Shift_Del_p.P465fs	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	465_466					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					CAAGGGGCGAGCGGCCCTCCGC	0.653													---	---	---								-	64573003	-	-	64573002	7	5	223	1	0	1	0	1	0	0	0	0	4994	971	34	0	38	0	EGR2	10	64573002	Frame_Shift_Del	DEL	GC	TCGA-CV-7101-01A-11D-2012-08	10498156	64573002	70961745	122	41016											
GRID1	2894	broad.mit.edu	37	chr10	87407143	87407143	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccacttgtttggacaggTcctggaaagtcctgaaatgc	9	13	10	9	0	0	1	0	1	0	0	3	3	3	3	3	3	1	1	3	3	2	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr10:87407143T>G	uc001kdl.1	-	13	2110	c.2009A>C	c.(2008-2010)GAC>GCC	p.D670A	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.D241A|uc001kdm.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	670	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TTTGGACAGGTCCTGGAAAGT	0.522										Multiple Myeloma(13;0.14)			14	153					0	0	0	0	G	87407143	G	G	87407143	3	3	223	1	0	0	0	0	1	0	0	0	6810	1667	58	5	1036	5	GRID1	10	87407143	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	22834141	87407143	48127604	123	41017											
IFIT5	24138	broad.mit.edu	37	chr10	91177111	91177111	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taccacaaaatctagacttgCtctttataacctattggcct	12	14	4	11	0	2	1	0	0	2	1	2	1	2	1	3	1	3	1	3	1	7	8			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr10:91177111C>T	uc010qnh.1	+	2	386	c.155C>T	c.(154-156)GCT>GTT	p.A52V	LIPA_uc001kgb.3_5'Flank|LIPA_uc001kgc.3_5'Flank|IFIT5_uc010qng.1_Missense_Mutation_p.A52V	NM_012420	NP_036552	Q13325	IFIT5_HUMAN	interferon-induced protein with	52	TPR 1.						binding				0						TCTAGACTTGCTCTTTATAAC	0.373													8	60					0	0	0	0	T	91177111	T	T	91177111	3	4	223	1	0	0	0	0	1	0	0	0	7564	797	28	4	161	4	IFIT5	10	91177111	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	3769968	91177111	44357636	124	41018											
NLRP6	171389	broad.mit.edu	37	chr11	281335	281335	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacactcctgcgtggggacgCccagccgcacagccacttgg	7	5	13	16	3	0	0	0	0	0	0	1	2	1	1	4	3	3	1	4	3	0	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:281335C>A	uc010qvs.1	+	4	1601	c.1601C>A	c.(1600-1602)GCC>GAC	p.A534D	NLRP6_uc010qvt.1_Missense_Mutation_p.A534D	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	534						cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGTGGGGACGCCCAGCCGCAC	0.687													12	16					1.5842e-08	3.24599e-08	1	0	A	281335	A	A	281335	3	1	223	1	0	0	0	0	1	0	0	0	10535	739	26	4	1615	4	NLRP6	11	281335	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08		281335	134725181	125	41019											
SLC25A22	79751	broad.mit.edu	37	chr11	792580	792580	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcgtggccccgagtcccttgTagagaccggcaatgccacgg	7	6	14	14	4	0	1	0	0	0	1	1	3	1	1	5	3	1	2	5	3	2	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:792580T>C	uc001lri.2	-	7	902	c.560A>G	c.(559-561)TAC>TGC	p.Y187C	CEND1_uc001lrh.1_5'Flank|SLC25A22_uc009yci.2_Missense_Mutation_p.Y187C|SLC25A22_uc001lrj.2_Missense_Mutation_p.Y187C	NM_024698	NP_078974	Q9H936	GHC1_HUMAN	mitochondrial glutamate carrier 1	187	Solcar 2.					integral to membrane|mitochondrial inner membrane|nucleus	L-glutamate transmembrane transporter activity|protein binding|symporter activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	L-Glutamic Acid(DB00142)	GAGTCCCTTGTAGAGACCGGC	0.731													7	19					0	0	0	0	C	792580	C	C	792580	3	2	223	1	0	0	0	0	1	0	0	0	14549	1638	57	5	427	5	SLC25A22	11	792580	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	511245	792580	134213936	126	41020											
C11orf16	56673	broad.mit.edu	37	chr11	8947244	8947244	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agcgtgcattgctactttctCctctttaggaccttccaggg	6	14	9	12	1	2	0	0	0	2	0	4	1	3	1	3	2	4	2	3	2	2	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:8947244C>G	uc001mhb.3	-	5	1094	c.970G>C	c.(970-972)GAG>CAG	p.E324Q	C11orf16_uc001mhc.3_Missense_Mutation_p.E324Q	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	324										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		GCTACTTTCTCCTCTTTAGGA	0.552													13	55					0	0	0	0	G	8947244	G	G	8947244	3	3	223	1	0	0	0	0	1	0	0	0	1637	864	30	2	441	2	C11orf16	11	8947244	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	8154664	8947244	126059272	127	41021											
C11orf16	56673	broad.mit.edu	37	chr11	8948556	8948556	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atactgctgttggcctggctCccagagtgccagcaccttat	7	11	10	13	0	0	1	0	0	0	1	1	1	1	1	4	2	4	4	4	2	2	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:8948556C>G	uc001mhb.3	-	4	614	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	C11orf16_uc001mhc.3_Missense_Mutation_p.E164Q	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	164										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		TGGCCTGGCTCCCAGAGTGCC	0.547													9	40					0	0	0	0	G	8948556	G	G	8948556	3	3	223	1	0	0	0	0	1	0	0	0	1637	864	30	2	925	2	C11orf16	11	8948556	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	1312	8948556	126057960	128	41022											
SBF2	81846	broad.mit.edu	37	chr11	10064472	10064472	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtctgtcaggacaaccacAaagaacgttggctgcttcct	11	10	9	11	1	2	1	1	0	1	1	3	2	3	2	2	2	3	3	2	2	3	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:10064472A>G	uc001mib.2	-	3	336	c.198T>C	c.(196-198)TTT>TTC	p.F66F	SBF2_uc001mif.3_5'UTR|SBF2_uc001mij.2_RNA	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	66	UDENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GGACAACCACAAAGAACGTTG	0.403													23	29					0	0	0	0	G	10064472	G	G	10064472	2	3	223	1	0	0	0	0	0	0	0	1	13924	127	5	5		5	SBF2	11	10064472	Silent	SNP	A	TCGA-CV-7101-01A-11D-2012-08	1115916	10064472	124942044	129	41023											
MYOD1	4654	broad.mit.edu	37	chr11	17741386	17741386	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacggcccccgacggctcTctctgctcctttgccacaac	5	9	8	19	3	2	1	0	1	2	0	4	2	3	1	4	2	3	2	4	2	1	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:17741386T>G	uc001mni.2	+	1	277	c.57T>G	c.(55-57)TCT>TCG	p.S19S		NM_002478	NP_002469	P15172	MYOD1_HUMAN	myogenic differentiation 1	19					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|ovary(1)	3						CCGACGGCTCTCTCTGCTCCT	0.652													23	40					0	0	0	0	G	17741386	G	G	17741386	2	3	223	1	0	0	0	0	0	0	0	1	10141	1538	54	5		5	MYOD1	11	17741386	Silent	SNP	T	TCGA-CV-7101-01A-11D-2012-08	7676914	17741386	117265130	130	41024											
DPF2	5977	broad.mit.edu	37	chr11	65108938	65108938	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtagtttagaggctctgttgCgcactgaccccctggagaag	8	10	13	10	1	1	3	0	1	1	2	1	4	1	3	2	2	1	5	2	2	3	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:65108938C>T	uc001odm.2	+	4	382	c.370C>T	c.(370-372)CGC>TGC	p.R124C	DPF2_uc001odn.2_Missense_Mutation_p.R124C|DPF2_uc010roe.1_Missense_Mutation_p.R124C	NM_006268	NP_006259	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	124					apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						GGCTCTGTTGCGCACTGACCC	0.567													10	40					0	0	0	0	T	65108938	T	T	65108938	3	4	223	1	0	0	0	0	1	0	0	0	4739	768	27	1	384	1	DPF2	11	65108938	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	47367552	65108938	69897578	131	41025											
PPFIA1	8500	broad.mit.edu	37	chr11	70176348	70176348	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacgctacctcgctgcacagCgtgaagccacatctgtgcat	10	8	9	14	3	1	1	0	1	1	0	2	1	1	1	2	0	6	4	2	0	3	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:70176348C>T	uc001opo.2	+	8	1198	c.1000C>T	c.(1000-1002)CGT>TGT	p.R334C	PPFIA1_uc001opn.1_Missense_Mutation_p.R334C|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	334	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CGCTGCACAGCGTGAAGCCAC	0.398													23	42					0	0	0	0	T	70176348	T	T	70176348	3	4	223	1	0	0	0	0	1	0	0	0	12364	768	27	1	1026	1	PPFIA1	11	70176348	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	5067410	70176348	64830168	132	41026											
NUMA1	4926	broad.mit.edu	37	chr11	71727303	71727306	+	Frame_Shift_Del	DEL	CCAG	-	-																															tgcctcttgcttcaaggtttCcagctggtggtataaagaga																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:71727303_71727306delCCAG	uc001orl.1	-	15	1415_1418	c.1243_1246delCTGG	c.(1243-1248)CTGGAAfs	p.L415fs	NUMA1_uc009ysw.1_5'UTR|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Frame_Shift_Del_p.L415fs|NUMA1_uc001orn.2_5'UTR|NUMA1_uc009ysx.1_Frame_Shift_Del_p.L415fs|NUMA1_uc001oro.1_Frame_Shift_Del_p.L415fs	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	415_416	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						TTCAAGGTTTCCAGCTGGTGGTAT	0.51			T	RARA	APL						OREG0021187	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	71727306	-	-	71727303	7	5	223	1	0	1	0	1	0	0	0	0	10804	864	30	0	5153	0	NUMA1	11	71727303	Frame_Shift_Del	DEL	CCAG	TCGA-CV-7101-01A-11D-2012-08	1550955	71727303	63279213	133	41027											
MLL	4297	broad.mit.edu	37	chr11	118392789	118392789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcgtaagatctaccgaggaGaggaactcacttacgactat	13	9	10	9	3	2	2	1	0	1	2	2	6	2	3	1	2	4	1	1	2	5	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:118392789G>A	uc001pta.2	+	36	11835	c.11812G>A	c.(11812-11814)GAG>AAG	p.E3938K	MLL_uc001ptb.2_Missense_Mutation_p.E3941K|MLL_uc001ptf.2_5'Flank	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3938	SET.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CTACCGAGGAGAGGAACTCAC	0.478			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								12	70					0	0	0	0	A	118392789	A	A	118392789	3	1	223	1	0	0	0	0	1	0	0	0	9673	943	33	2	11954	2	MLL	11	118392789	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	46665486	118392789	16613727	134	41028											
SRPR	6734	broad.mit.edu	37	chr11	126136385	126136385	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttaccaggttgatgtcctCagacaaggcagcctcagggg	9	9	12	11	0	3	2	2	1	1	1	4	2	4	2	3	4	2	2	3	4	2	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr11:126136385C>T	uc001qdh.2	-	6	877	c.826G>A	c.(826-828)GAG>AAG	p.E276K	SRPR_uc010sbm.1_Missense_Mutation_p.E248K|FOXRED1_uc001qdi.2_5'Flank|FOXRED1_uc010sbn.1_5'Flank|FOXRED1_uc010sbo.1_5'Flank|FOXRED1_uc010sbp.1_5'Flank|FOXRED1_uc010sbq.1_5'Flank|FOXRED1_uc001qdj.2_5'Flank|FOXRED1_uc010sbr.1_5'Flank	NM_003139	NP_003130	P08240	SRPR_HUMAN	signal recognition particle receptor	276					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding				0	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		TTGATGTCCTCAGACAAGGCA	0.488													15	71					0	0	0	0	T	126136385	T	T	126136385	3	4	223	1	0	0	0	0	1	0	0	0	15228	835	29	2	1126	2	SRPR	11	126136385	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	7743596	126136385	8870131	135	41029											
CD163	9332	broad.mit.edu	37	chr12	7636160	7636160	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagttgttgacacaccaccTgagcatcgtccaagtcccaa	12	8	7	14	1	0	2	0	2	0	0	3	2	2	2	4	0	1	3	4	0	3	2	rs141756075	by1000genomes	TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr12:7636160T>G	uc001qsz.3	-	12	3019	c.2891A>C	c.(2890-2892)CAG>CCG	p.Q964P	CD163_uc001qta.3_Missense_Mutation_p.Q964P|CD163_uc009zfw.2_Missense_Mutation_p.Q997P	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	964	SRCR 9.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						ACACACCACCTGAGCATCGTC	0.522													10	69					0	0	0	0	G	7636160	G	G	7636160	3	3	223	1	0	0	0	0	1	0	0	0	2982	1580	55	5	599	5	CD163	12	7636160	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08		7636160	126215735	136	41030											
DENND5B	160518	broad.mit.edu	37	chr12	31552693	31552693	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctgaacagtggtcagcttcCccaagttctggcactgtagg	8	11	11	11	0	3	1	1	1	2	0	4	1	4	1	2	3	2	4	2	3	3	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr12:31552693C>T	uc001rki.1	-	16	3149	c.2963G>A	c.(2962-2964)GGG>GAG	p.G988E	DENND5B_uc001rkh.1_Missense_Mutation_p.G1023E|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	988	PLAT.					integral to membrane				ovary(1)|central_nervous_system(1)	2						GGTCAGCTTCCCCAAGTTCTG	0.443													10	20					0	0	0	0	T	31552693	T	T	31552693	3	4	223	1	0	0	0	0	1	0	0	0	4459	623	22	4	885	4	DENND5B	12	31552693	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	23916533	31552693	102299202	137	41031											
TROAP	10024	broad.mit.edu	37	chr12	49722756	49722756	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccctgcccctgtggcccAgcccttgcctggccatgtgg	2	9	11	19	0	0	0	0	0	0	0	1	0	1	0	8	3	3	0	8	3	0	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr12:49722756A>G	uc001rtx.3	+	9	1105	c.938A>G	c.(937-939)CAG>CGG	p.Q313R	TROAP_uc009zlh.2_Missense_Mutation_p.Q313R|TROAP_uc001rty.2_Missense_Mutation_p.Q21R	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	313					cell adhesion	cytoplasm				ovary(1)	1						CCTGTGGCCCAGCCCTTGCCT	0.572													29	57					0	0	0	0	G	49722756	G	G	49722756	3	3	223	1	0	0	0	0	1	0	0	0	16642	188	7	5	1070	5	TROAP	12	49722756	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08	18170063	49722756	84129139	138	41032											
PPFIA2	8499	broad.mit.edu	37	chr12	81661805	81661805	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaagtatattatttgcataTtctcgaagtccaattgcttg	11	17	6	7	1	2	0	1	0	1	0	4	1	3	0	1	0	2	3	1	0	7	8			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr12:81661805T>C	uc001szo.1	-	29	3533	c.3372A>G	c.(3370-3372)GAA>GAG	p.E1124E	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	1023										ovary(3)|lung(2)|pancreas(1)	6						TATTTGCATATTCTCGAAGTC	0.393													4	8					0	0	0	0	C	81661805	C	C	81661805	2	2	223	1	0	0	0	0	0	0	0	1	12365	1490	52	5		5	PPFIA2	12	81661805	Silent	SNP	T	TCGA-CV-7101-01A-11D-2012-08	31939049	81661805	52190090	139	41033											
TXNRD1	7296	broad.mit.edu	37	chr12	104720144	104720144	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgatgctggcaataggaaGagatgcttgcacaagaaaaa	16	7	13	5	0	0	3	0	1	0	2	0	5	0	4	0	3	3	4	0	3	6	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr12:104720144G>C	uc010swk.1	+	12	1350	c.1328G>C	c.(1327-1329)AGA>ACA	p.R443T	TXNRD1_uc010swl.1_Missense_Mutation_p.R293T|TXNRD1_uc010swm.1_Missense_Mutation_p.R345T|TXNRD1_uc010swn.1_Missense_Mutation_p.R293T|TXNRD1_uc010swo.1_Missense_Mutation_p.R293T|TXNRD1_uc010swp.1_Missense_Mutation_p.R255T|TXNRD1_uc010swq.1_Missense_Mutation_p.R343T|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.R359T	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	443					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						GCAATAGGAAGAGATGCTTGC	0.289													2	1					0	0	0	0	C	104720144	C	C	104720144	3	2	223	1	0	0	0	0	1	0	0	0	16875	942	33	2	1388	2	TXNRD1	12	104720144	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	23058339	104720144	29131751	140	41034											
SPPL3	121665	broad.mit.edu	37	chr12	121221519	121221519	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgttaaatactggcacatcGggaggagaagaaaagcaaaa	18	7	11	5	1	0	2	0	0	0	2	1	4	0	3	0	3	2	3	0	3	8	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr12:121221519G>C	uc001tzd.2	-	5	828	c.347C>G	c.(346-348)CCG>CGG	p.P116R	SPPL3_uc009zwz.2_Missense_Mutation_p.P116R	NM_139015	NP_620584	Q8TCT6	PSL4_HUMAN	signal peptide peptidase 3	117	Helical; (Potential).					integral to membrane	aspartic-type endopeptidase activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CTGGCACATCGGGAGGAGAAG	0.323													15	13					0	0	0	0	C	121221519	C	C	121221519	3	2	223	1	0	0	0	0	1	0	0	0	15156	1116	39	3	835	3	SPPL3	12	121221519	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	16501375	121221519	12630376	141	41035											
TMEM132D	121256	broad.mit.edu	37	chr12	129563188	129563188	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccctgtcaccagctgcaccCcgaggtctgtgatggtcacc	6	8	11	16	1	3	1	2	1	1	0	3	2	3	1	5	2	2	2	5	2	0	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr12:129563188C>A	uc009zyl.1	-	8	2334	c.2006G>T	c.(2005-2007)GGG>GTG	p.G669V	TMEM132D_uc001uia.2_Missense_Mutation_p.G207V	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	669	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CAGCTGCACCCCGAGGTCTGT	0.582													34	56					1.61788e-16	3.47083e-16	1	0	A	129563188	A	A	129563188	3	1	223	1	0	0	0	0	1	0	0	0	16113	623	22	4	1301	4	TMEM132D	12	129563188	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	8341669	129563188	4288707	142	41036											
NBEA	26960	broad.mit.edu	37	chr13	36229091	36229091	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtaacagcagataatcgctAtattcttatctgtggattct	11	15	8	7	1	3	1	0	0	3	1	4	2	3	2	0	2	2	3	0	2	5	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr13:36229091A>T	uc001uvb.2	+	53	8278	c.8072A>T	c.(8071-8073)TAT>TTT	p.Y2691F	NBEA_uc010abi.2_Missense_Mutation_p.Y1347F|NBEA_uc010tef.1_Missense_Mutation_p.Y484F|NBEA_uc001uvd.2_Missense_Mutation_p.Y269F	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2691						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GATAATCGCTATATTCTTATC	0.368													13	21					0	0	0	0	T	36229091	T	T	36229091	3	4	223	1	0	0	0	0	1	0	0	0	10240	449	16	5	8282	5	NBEA	13	36229091	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08		36229091	78940787	143	41037											
SLITRK5	26050	broad.mit.edu	37	chr13	88330022	88330023	+	Missense_Mutation	DNP	GC	AA	AA																															agcagcaaccaccacctgcaGcagcagcagcagccgccgcc																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr13:88330022_88330023GC>AA	uc001vln.2	+	2	2598_2599	c.2379_2380GC>AA	c.(2377-2382)CAGCAG>CAAAAG	p.Q794K	SLITRK5_uc010tic.1_Missense_Mutation_p.Q553K	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	794	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ACCACCTgcagcagcagcagca	0.376													12	18					0	0	0	0	AA	88330023	AA	AA	88330022	3	1	223	1	0	0	0	0	1	0	0	0	14810	962	34	4	2381	4	SLITRK5	13	88330022	Missense_Mutation	DNP	GC	TCGA-CV-7101-01A-11D-2012-08	52100931	88330022	26839856	144	41038											
FARP1	10160	broad.mit.edu	37	chr13	99043103	99043103	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggttctcgactatgttaaaGaaggaggacataagaaggtg	15	9	13	4	1	1	2	0	0	1	2	2	5	1	4	0	4	0	2	0	4	6	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr13:99043103G>C	uc001vnj.2	+	11	1393	c.1057G>C	c.(1057-1059)GAA>CAA	p.E353Q	FARP1_uc001vnh.2_Missense_Mutation_p.E353Q	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	353					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CTATGTTAAAGAAGGAGGACA	0.453													20	71					0	0	0	0	C	99043103	C	C	99043103	3	2	223	1	0	0	0	0	1	0	0	0	5708	943	33	2	1318	2	FARP1	13	99043103	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	10713081	99043103	16126775	145	41039											
ZIC5	85416	broad.mit.edu	37	chr13	100622499	100622499	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgcggatgtggttgatgagCttgtatttggccttgaaggg	7	13	16	5	2	0	3	0	3	0	0	0	4	0	4	1	4	1	3	1	4	2	5			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr13:100622499C>G	uc001vom.1	-	1	1680	c.1431G>C	c.(1429-1431)AAG>AAC	p.K477N		NM_033132	NP_149123	Q96T25	ZIC5_HUMAN	zinc finger protein of the cerebellum 5	477	C2H2-type 1; atypical.				cell differentiation	nucleus	DNA binding|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GGTTGATGAGCTTGTATTTGG	0.642													5	113					0	0	0	0	G	100622499	G	G	100622499	3	3	223	1	0	0	0	0	1	0	0	0	17749	796	28	4	568	4	ZIC5	13	100622499	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	1579396	100622499	14547379	146	41040											
MCF2L	23263	broad.mit.edu	37	chr13	113678963	113678963	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtctctccccaggtgggCgggggcaggacggaagcccg	5	5	18	13	3	1	0	0	0	1	0	3	2	2	2	3	7	1	1	3	7	1	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr13:113678963C>T	uc001vsu.2	+	3	362	c.340C>T	c.(340-342)CGG>TGG	p.R114W	MCF2L_uc001vsq.2_Missense_Mutation_p.R114W|MCF2L_uc010tjr.1_Missense_Mutation_p.R57W|MCF2L_uc001vsr.2_Missense_Mutation_p.R61W|MCF2L_uc001vss.3_Missense_Mutation_p.R55W|MCF2L_uc010tjs.1_Missense_Mutation_p.R55W	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	87	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CCCAGGTGGGCGGGGGCAGGA	0.612													7	77					0	0	0	0	T	113678963	T	T	113678963	3	4	223	1	0	0	0	0	1	0	0	0	9432	759	27	1	445	1	MCF2L	13	113678963	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	13056464	113678963	1490915	147	41041											
TPPP2	122664	broad.mit.edu	37	chr14	21499312	21499312	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggcaaagacccagccacCactggcgctactgtgagtga	11	5	13	12	1	0	3	0	2	0	1	0	4	0	3	3	2	2	2	3	2	2	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr14:21499312C>A	uc001vzh.2	+	3	503	c.315C>A	c.(313-315)ACC>ACA	p.T105T	NDRG2_uc010tll.1_Intron	NM_173846	NP_776245	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family	105						cytoplasm					0	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		ACCCAGCCACCACTGGCGCTA	0.537													11	47					3.07112e-06	6.1668e-06	1	0	A	21499312	A	A	21499312	2	1	223	1	0	0	0	0	0	0	0	1	16481	581	21	4		4	TPPP2	14	21499312	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08		21499312	85850228	148	41042											
SLC7A7	9056	broad.mit.edu	37	chr14	23243254	23243254	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccgatgagggagttgatagtAtcactgtaaagtggaacagc	13	9	13	6	1	1	2	1	2	0	0	1	5	1	4	1	2	2	3	1	2	5	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr14:23243254A>G	uc001wgr.3	-	9	1455	c.1317T>C	c.(1315-1317)GAT>GAC	p.D439D	SLC7A7_uc001wgs.3_Silent_p.D439D|SLC7A7_uc001wgt.3_Silent_p.D439D|SLC7A7_uc001wgu.3_Silent_p.D439D|SLC7A7_uc001wgv.3_Silent_p.D439D	NM_003982	NP_003973	Q9UM01	YLAT1_HUMAN	solute carrier family 7 member 7	439					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			ovary(1)|breast(1)	2	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		AGTTGATAGTATCACTGTAAA	0.507													34	60					0	0	0	0	G	23243254	G	G	23243254	2	3	223	1	0	0	0	0	0	0	0	1	14767	446	16	5		5	SLC7A7	14	23243254	Silent	SNP	A	TCGA-CV-7101-01A-11D-2012-08	1743942	23243254	84106286	149	41043											
NYNRIN	57523	broad.mit.edu	37	chr14	24885013	24885013	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccttacacgccaacctatgCccacctggcagccgtggcct	7	7	8	19	2	0	0	0	0	0	0	0	0	0	0	7	2	4	1	7	2	3	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr14:24885013C>T	uc001wpf.3	+	9	4376	c.4058C>T	c.(4057-4059)GCC>GTC	p.A1353V		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1353					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						CCAACCTATGCCCACCTGGCA	0.607													16	131					0	0	0	0	T	24885013	T	T	24885013	3	4	223	1	0	0	0	0	1	0	0	0	10850	739	26	4	4088	4	NYNRIN	14	24885013	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	1641759	24885013	82464527	150	41044											
GZMB	3002	broad.mit.edu	37	chr14	25100420	25100420	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagagggcctccagagtcccCctgtgaatagagagtggaag	12	6	14	9	0	0	4	0	1	0	3	2	6	2	5	4	2	0	0	4	2	4	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr14:25100420C>G	uc001wps.2	-	5	667	c.601G>C	c.(601-603)GGG>CGG	p.G201R	GZMB_uc010ama.2_Missense_Mutation_p.G189R|GZMB_uc010amb.2_RNA	NM_004131	NP_004122	P10144	GRAB_HUMAN	granzyme B precursor	201	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.028)		CCAGAGTCCCCCTGTGAATAG	0.557													5	68					0	0	0	0	G	25100420	G	G	25100420	3	3	223	1	0	0	0	0	1	0	0	0	6955	637	22	4	146	4	GZMB	14	25100420	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	215407	25100420	82249120	151	41045											
KIAA0317	9870	broad.mit.edu	37	chr14	75140809	75140809	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtagaactccttcactgaGaattgctggaggaccaacag	13	8	11	9	0	1	2	1	1	0	2	2	5	2	4	2	3	3	2	2	3	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr14:75140809G>T	uc001xqb.2	-	9	1591	c.1086C>A	c.(1084-1086)TTC>TTA	p.F362L	KIAA0317_uc010tut.1_Missense_Mutation_p.F201L|KIAA0317_uc001xqc.2_Missense_Mutation_p.F362L	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	362					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		CCTTCACTGAGAATTGCTGGA	0.403													25	25					9.39395e-14	1.9982e-13	1	0	T	75140809	T	T	75140809	3	4	223	1	0	0	0	0	1	0	0	0	8206	933	33	2	1433	2	KIAA0317	14	75140809	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	50040389	75140809	32208731	152	41046											
ASPG	374569	broad.mit.edu	37	chr14	104570801	104570801	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcctccagggggctgtgaCcacagactatgcagctggca	8	7	13	13	0	0	2	0	1	0	1	1	2	1	2	3	3	3	4	3	3	1	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr14:104570801C>T	uc001yoq.1	+	8	974	c.914C>T	c.(913-915)ACC>ATC	p.T305I	ASPG_uc001yoo.1_Missense_Mutation_p.T333I|ASPG_uc001yop.1_Missense_Mutation_p.T305I|ASPG_uc001yor.1_Missense_Mutation_p.T305I	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	305	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						GGGGCTGTGACCACAGACTAT	0.672													8	43					0	0	0	0	T	104570801	T	T	104570801	3	4	223	1	0	0	0	0	1	0	0	0	1054	507	18	4	944	4	ASPG	14	104570801	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	29429992	104570801	2778739	153	41047											
MTA1	9112	broad.mit.edu	37	chr14	105920571	105920571	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctacgacccacagcagaaGaccctgctggcagataaagg	13	5	11	12	1	1	3	0	0	1	3	1	4	1	3	2	2	3	3	2	2	4	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr14:105920571G>A	uc001yqx.2	+	7	661	c.474G>A	c.(472-474)AAG>AAA	p.K158K	MTA1_uc001yqy.2_RNA|MTA1_uc001yqz.1_Silent_p.K72K|MTA1_uc001yra.1_Silent_p.K72K	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	158	BAH.				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CACAGCAGAAGACCCTGCTGG	0.537													10	49					0	0	0	0	A	105920571	A	A	105920571	2	1	223	1	0	0	0	0	0	0	0	1	9961	933	33	2		2	MTA1	14	105920571	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	1349770	105920571	1428969	154	41048											
CYFIP1	23191	broad.mit.edu	37	chr15	22935896	22935896	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtacctgatggatgggagtGtcagtaacatctataagttg	11	13	12	5	0	2	1	1	1	1	0	2	3	2	3	1	2	2	3	1	2	4	5			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr15:22935896G>A	uc001yus.2	+	9	936	c.832G>A	c.(832-834)GTC>ATC	p.V278I	CYFIP1_uc001yut.2_Missense_Mutation_p.V278I|CYFIP1_uc010aya.1_Missense_Mutation_p.V306I	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	278					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GGATGGGAGTGTCAGTAACAT	0.373													6	30					0	0	0	0	A	22935896	A	A	22935896	3	1	223	1	0	0	0	0	1	0	0	0	4154	1377	48	4	862	4	CYFIP1	15	22935896	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08		22935896	79595496	155	41049											
HERC2	8924	broad.mit.edu	37	chr15	28386588	28386588	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctcttaccttcccatcaGccgtcacagcaaagagggtc	10	8	9	14	1	3	1	2	0	1	1	5	2	4	1	3	1	4	2	3	1	2	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr15:28386588G>T	uc001zbj.2	-	78	12111	c.12005C>A	c.(12004-12006)GCT>GAT	p.A4002D		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4002	RCC1 13.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTTCCCATCAGCCGTCACAGC	0.517													30	21					8.88839e-20	1.91501e-19	1	0	T	28386588	T	T	28386588	3	4	223	1	0	0	0	0	1	0	0	0	7097	971	34	4	2563	4	HERC2	15	28386588	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	5450692	28386588	74144804	156	41050											
NDNL2	56160	broad.mit.edu	37	chr15	29561491	29561491	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttcaagttccaccagcttaTacccgaagacgtactggagg	11	9	10	11	2	1	1	1	0	0	1	2	3	2	2	3	2	3	4	3	2	5	5			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr15:29561491T>C	uc001zco.2	-	1	527	c.419A>G	c.(418-420)TAT>TGT	p.Y140C	FAM189A1_uc010azk.1_Intron	NM_138704	NP_619649	Q96MG7	MAGG1_HUMAN	necdin-like 2	140	MAGE.				regulation of growth	cytoplasm|nucleus					0		all_lung(180;4.69e-11)|Breast(32;0.0013)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00736)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CACCAGCTTATACCCGAAGAC	0.577													3	89					0	0	0	0	C	29561491	C	C	29561491	3	2	223	1	0	0	0	0	1	0	0	0	10302	1406	49	5	499	5	NDNL2	15	29561491	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	1174903	29561491	72969901	157	41051											
CEP152	22995	broad.mit.edu	37	chr15	49054851	49054851	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccactccttttcaagctgttGaatgagtttttctttgatct	7	19	6	9	0	3	3	1	3	2	0	4	3	4	3	2	0	1	3	2	0	2	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr15:49054851G>C	uc001zwy.2	-	18	2333	c.2299C>G	c.(2299-2301)CAA>GAA	p.Q767E	CEP152_uc001zwz.2_Missense_Mutation_p.Q767E|CEP152_uc001zxa.1_Missense_Mutation_p.Q674E	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	767	Potential.				centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TCAAGCTGTTGAATGAGTTTT	0.348													39	31					0	0	0	0	C	49054851	C	C	49054851	3	2	223	1	0	0	0	0	1	0	0	0	3263	1299	45	2	2701	2	CEP152	15	49054851	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	19493360	49054851	53476541	158	41052											
VPS13C	54832	broad.mit.edu	37	chr15	62165605	62165612	+	Splice_Site	DEL	CCACCTAT	-	-																															gagatacaactcctgctgcaCcacctatcaaagacaaggga																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr15:62165605_62165612delCCACCTAT	uc002agz.2	-	78	10489	c.10415_splice	c.e78-1	p.G3472_splice	VPS13C_uc002aha.2_Splice_Site_p.G3429_splice|VPS13C_uc002ahb.1_Splice_Site_p.G3472_splice|VPS13C_uc002ahc.1_Splice_Site_p.G3429_splice	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A						protein localization					ovary(2)	2						TCCTGCTGCaccacctatcaaagacaag	0.207													---	---	---								-	62165612	-	-	62165605	8	5	223	1	0	1	0	1	0	0	1	0	17259	507	18	0	903	0	VPS13C	15	62165605	Splice_Site	DEL	CCACCTAT	TCGA-CV-7101-01A-11D-2012-08	13110754	62165605	40365787	159	41053											
RPS27L	51065	broad.mit.edu	37	chr15	63447855	63447855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttcctcctgtaggctggCacaacactgttgaacaacct	9	11	7	14	0	0	1	0	1	0	0	2	1	2	1	4	2	3	4	4	2	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr15:63447855C>T	uc002aly.2	-	3	328	c.191G>A	c.(190-192)TGC>TAC	p.C64Y	RPS27L_uc002alx.2_RNA	NM_015920	NP_057004	Q71UM5	RS27L_HUMAN	ribosomal protein S27-like	64					DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of anti-apoptosis|translation	nucleus|ribosome	caspase activator activity|metal ion binding|structural constituent of ribosome|translation activator activity				0						TGTAGGCTGGCACAACACTGT	0.413													5	66					0	0	0	0	T	63447855	T	T	63447855	3	4	223	1	0	0	0	0	1	0	0	0	13705	710	25	4	71	4	RPS27L	15	63447855	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	1282250	63447855	39083537	160	41054											
WHAMM	123720	broad.mit.edu	37	chr15	83478538	83478538	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccggtccgggagggcctcttCgccgagcccgagaggcaccg	5	4	16	16	6	1	1	0	0	1	1	3	4	2	2	6	4	1	1	6	4	0	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr15:83478538C>T	uc002bje.2	+	1	566	c.60C>T	c.(58-60)TTC>TTT	p.F20F		NM_001080435	NP_001073904	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi	20						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding				0						AGGGCCTCTTCGCCGAGCCCG	0.731													12	20					0	0	0	0	T	83478538	T	T	83478538	2	4	223	1	0	0	0	0	0	0	0	1	17429	883	31	1		1	WHAMM	15	83478538	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	20030683	83478538	19052854	161	41055											
SLC28A1	9154	broad.mit.edu	37	chr15	85487997	85487997	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccctctacagggatcctctaCatgcccaggggggctgaagt	8	8	12	13	0	2	1	0	1	2	0	3	2	3	2	3	4	3	1	3	4	3	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr15:85487997C>T	uc002blg.2	+	18	1975	c.1773C>T	c.(1771-1773)TAC>TAT	p.Y591Y	SLC28A1_uc010bnb.2_Silent_p.Y591Y|SLC28A1_uc010upe.1_Silent_p.Y425Y|SLC28A1_uc010upf.1_Silent_p.Y591Y|SLC28A1_uc010upg.1_Intron	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	591	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGATCCTCTACATGCCCAGGG	0.597													49	42					0	0	0	0	T	85487997	T	T	85487997	2	4	223	1	0	0	0	0	0	0	0	1	14595	489	17	4		4	SLC28A1	15	85487997	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	2009459	85487997	17043395	162	41056											
HBA2	3040	broad.mit.edu	37	chr16	223537	223537	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgagttcacccctgcggtgCacgcctccctggacaagttc	6	8	10	17	3	1	0	1	0	0	0	3	2	2	1	5	2	2	3	5	2	1	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:223537C>T	uc002cfv.3	+	3	433	c.367C>T	c.(367-369)CAC>TAC	p.H123Y	HBA2_uc002cfw.2_Intron	NM_000517	NP_000508	P69905	HBA_HUMAN	alpha 2 globin	123			H -> Q (in Westmead).		hydrogen peroxide catabolic process|positive regulation of cell death|protein heterooligomerization	cytosolic small ribosomal subunit|haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity|protein binding				0		all_cancers(16;2.03e-06)|all_epithelial(16;5.16e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0138)|all_lung(18;0.0306)			Amodiaquine(DB00613)|Chloroquine(DB00608)|Iron Dextran(DB00893)|Mefloquine(DB00358)|Primaquine(DB01087)|Quinine(DB00468)	CCCTGCGGTGCACGCCTCCCT	0.662											OREG0003686	type=REGULATORY REGION|Gene=SERPINB9|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	5	23					0	0	0	0	T	223537	T	T	223537	3	4	223	1	0	0	0	0	1	0	0	0	7016	710	25	4	377	4	HBA2	16	223537	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08		223537	90131216	163	41057											
CORO7	79585	broad.mit.edu	37	chr16	4408429	4408429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgacgcagccgcaggcacCgcatcagctccacttcccgc	8	5	9	19	4	1	1	1	1	0	0	3	1	3	1	4	1	2	5	4	1	0	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:4408429C>T	uc002cwh.3	-	24	2516	c.2396G>A	c.(2395-2397)CGG>CAG	p.R799Q	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.R799Q|CORO7_uc002cwg.3_Missense_Mutation_p.R579Q|CORO7_uc010uxh.1_Missense_Mutation_p.R781Q|CORO7_uc010uxi.1_Missense_Mutation_p.R714Q|CORO7_uc002cwi.1_Missense_Mutation_p.R579Q	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	799						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						CCGCAGGCACCGCATCAGCTC	0.697													5	33					0	0	0	0	T	4408429	T	T	4408429	3	4	223	1	0	0	0	0	1	0	0	0	3774	652	23	1	401	1	CORO7	16	4408429	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	4184892	4408429	85946324	164	41058											
MYH11	4629	broad.mit.edu	37	chr16	15820749	15820749	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagctccgcccgggcccgctCcccatcgctgcacttggact	4	7	11	19	4	0	0	0	0	0	0	3	2	2	1	5	2	2	4	5	2	0	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:15820749C>T	uc002ddy.2	-	28	3921	c.3814G>A	c.(3814-3816)GAG>AAG	p.E1272K	MYH11_uc002ddv.2_Missense_Mutation_p.E1279K|MYH11_uc002ddw.2_Missense_Mutation_p.E1272K|MYH11_uc002ddx.2_Missense_Mutation_p.E1279K|MYH11_uc010bvg.2_Missense_Mutation_p.E1104K|MYH11_uc010bvh.2_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1272	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CGGGCCCGCTCCCCATCGCTG	0.647			T	CBFB	AML								6	150					0	0	0	0	T	15820749	T	T	15820749	3	4	223	1	0	0	0	0	1	0	0	0	10084	864	30	2	2195	2	MYH11	16	15820749	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	11412320	15820749	74534004	165	41059											
C16orf62	57020	broad.mit.edu	37	chr16	19586419	19586419	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaattttatgtctctgcaGaatctgtttatgggatctga	10	17	9	5	0	3	3	0	2	3	1	4	4	3	4	0	1	1	2	0	1	4	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:19586419G>A	uc002dgn.1	+	5	421	c.409_splice	c.e5-1	p.N137_splice	C16orf62_uc002dgo.1_Splice_Site_p.N137_splice|C16orf62_uc010vas.1_Splice_Site|C16orf62_uc002dgm.1_Splice_Site_p.N137_splice	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020							integral to membrane				ovary(1)	1						TGTCTCTGCAGAATCTGTTTA	0.294													5	33					0	0	0	0	A	19586419	A	A	19586419	5	1	223	1	0	0	0	0	0	0	1	0	1831	956	33	2	426	2	C16orf62	16	19586419	Splice_Site	SNP	G	TCGA-CV-7101-01A-11D-2012-08	3765670	19586419	70768334	166	41060											
EEF2K	29904	broad.mit.edu	37	chr16	22271782	22271782	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtctgtttctccctgcccaGattggccagtgttcagtgac	5	14	10	12	0	3	2	1	1	2	1	4	2	3	2	3	1	1	2	3	1	0	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:22271782G>C	uc002dki.2	+	11	1717	c.1232_splice	c.e11-1	p.H411_splice	EEF2K_uc002dkh.2_Splice_Site	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase						insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		TCCCTGCCCAGATTGGCCAGT	0.547													5	115					0	0	0	0	C	22271782	C	C	22271782	5	2	223	1	0	0	0	0	0	0	1	0	4952	956	33	2	1269	2	EEF2K	16	22271782	Splice_Site	SNP	G	TCGA-CV-7101-01A-11D-2012-08	2685363	22271782	68082971	167	41061											
SH2B1	25970	broad.mit.edu	37	chr16	28877954	28877954	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggaccgttgaccctccctCctccgctgggcccctggaga	4	7	13	17	2	0	2	0	1	0	1	3	4	3	3	7	4	0	2	7	4	0	1	rs144107554		TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:28877954C>T	uc002dri.2	+	4	978	c.539C>T	c.(538-540)TCC>TTC	p.S180F	uc010vct.1_Intron|SH2B1_uc010vdc.1_Intron|SH2B1_uc002drj.2_Missense_Mutation_p.S180F|SH2B1_uc002drk.2_Missense_Mutation_p.S180F|SH2B1_uc002drl.2_Missense_Mutation_p.S180F|SH2B1_uc010vdd.1_Intron|SH2B1_uc010vde.1_Missense_Mutation_p.S180F|SH2B1_uc002drm.2_Missense_Mutation_p.S180F	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	180	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Interaction with RAC1 (By similarity).|Required for NGF signaling (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						GACCCTCCCTCCTCCGCTGGG	0.652													19	46					0	0	0	0	T	28877954	T	T	28877954	3	4	223	1	0	0	0	0	1	0	0	0	14292	855	30	2	541	2	SH2B1	16	28877954	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	6606172	28877954	61476799	168	41062											
CES1	1066	broad.mit.edu	37	chr16	55862770	55862770	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtccaagaggcggcttggCaaaagggattcccaggaaaa	13	5	15	8	1	0	1	0	0	0	1	2	3	2	3	2	6	0	2	2	6	5	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:55862770C>A	uc002eim.2	-	2	274	c.166G>T	c.(166-168)GCC>TCC	p.A56S	CES1_uc002eil.2_Missense_Mutation_p.A57S|CES1_uc002ein.2_Missense_Mutation_p.A56S	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	56				A -> G (in Ref. 2; AAA16036/AAA35711).	response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	GGCGGCTTGGCAAAAGGGATT	0.557													11	64					3.86212e-05	7.57338e-05	1	0	A	55862770	A	A	55862770	3	1	223	1	0	0	0	0	1	0	0	0	3284	710	25	4	1589	4	CES1	16	55862770	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	26984816	55862770	34491983	169	41063											
RSPRY1	89970	broad.mit.edu	37	chr16	57238809	57238809	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggagccaaccacgggaccCtgttcggccaccaaggaggg	11	3	14	13	2	0	0	0	0	0	0	1	3	0	3	5	5	2	1	5	5	3	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:57238809C>A	uc002elb.2	+	2	517	c.239C>A	c.(238-240)CCT>CAT	p.P80H	RSPRY1_uc002elc.2_Missense_Mutation_p.P80H|RSPRY1_uc002eld.2_Missense_Mutation_p.P80H|RSPRY1_uc002ele.1_Missense_Mutation_p.P80H	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	80						extracellular region	zinc ion binding			ovary(1)	1						CCACGGGACCCTGTTCGGCCA	0.547													7	67					0.000157383	0.000303871	1	0	A	57238809	A	A	57238809	3	1	223	1	0	0	0	0	1	0	0	0	13778	681	24	4	241	4	RSPRY1	16	57238809	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	1376039	57238809	33115944	170	41064											
CDH11	1009	broad.mit.edu	37	chr16	64984742	64984742	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccggcgttcagaatgtaggCctctgcgttgcaggagagca	8	8	15	10	3	2	2	1	0	1	2	2	3	2	2	2	3	3	5	2	3	2	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:64984742C>A	uc002eoi.2	-	12	2256	c.1822G>T	c.(1822-1824)GCC>TCC	p.A608S	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Missense_Mutation_p.A608S|CDH11_uc010vin.1_Missense_Mutation_p.A482S	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	608	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AGAATGTAGGCCTCTGCGTTG	0.637			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			17	26					4.7546e-09	9.82227e-09	1	0	A	64984742	A	A	64984742	3	1	223	1	0	0	0	0	1	0	0	0	3112	739	26	4	576	4	CDH11	16	64984742	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	7745933	64984742	25370011	171	41065											
RLTPR	146206	broad.mit.edu	37	chr16	67683451	67683451	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctgaccgcgctggatatCagcggcaacgccatggggga	10	5	14	12	4	1	1	1	1	0	0	1	3	1	3	3	4	3	2	3	4	3	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:67683451C>T	uc002etn.2	+	20	1968	c.1848C>T	c.(1846-1848)ATC>ATT	p.I616I	RLTPR_uc010cel.1_Silent_p.I609I|RLTPR_uc010vjr.1_Silent_p.I580I	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	616	Tropomodulin-like.|LRR 14.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CGCTGGATATCAGCGGCAACG	0.672													10	46					0	0	0	0	T	67683451	T	T	67683451	2	4	223	1	0	0	0	0	0	0	0	1	13459	816	29	2		2	RLTPR	16	67683451	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	2698709	67683451	22671302	172	41066											
CENPT	80152	broad.mit.edu	37	chr16	67862656	67862656	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatagtggctcagtccagcCttgtggggatcttgccgggg	6	10	15	10	1	2	0	1	0	1	0	3	1	3	1	3	5	2	1	3	5	1	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:67862656C>G	uc002eun.3	-	14	1920	c.1371G>C	c.(1369-1371)AAG>AAC	p.K457N	CENPT_uc002eum.3_Missense_Mutation_p.K402N|CENPT_uc010vkc.1_Missense_Mutation_p.K215N|CENPT_uc010vkd.1_Missense_Mutation_p.K210N	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	457					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		TCAGTCCAGCCTTGTGGGGAT	0.587													12	171					0	0	0	0	G	67862656	G	G	67862656	3	3	223	1	0	0	0	0	1	0	0	0	3257	680	24	4	326	4	CENPT	16	67862656	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	179205	67862656	22492097	173	41067											
EDC4	23644	broad.mit.edu	37	chr16	67917557	67917557	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttgggcagccaccctgcccGctctcccagcctgtgctcct	3	10	9	19	1	1	0	0	0	1	0	3	0	2	0	6	1	4	3	6	1	0	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:67917557G>A	uc002eur.2	+	28	4102	c.3936G>A	c.(3934-3936)CCG>CCA	p.P1312P	EDC4_uc010cer.2_Silent_p.P931P|EDC4_uc002eus.2_Silent_p.P1042P|EDC4_uc002eut.1_3'UTR|NRN1L_uc002euu.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	1312					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CACCCTGCCCGCTCTCCCAGC	0.587											OREG0023890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	186					0	0	0	0	A	67917557	A	A	67917557	2	1	223	1	0	0	0	0	0	0	0	1	4930	1074	38	1		1	EDC4	16	67917557	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	54901	67917557	22437196	174	41068											
BCAR1	9564	broad.mit.edu	37	chr16	75276926	75276926	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgtcatgatgtcacccttGcggaaggagagctcatccgg	9	8	12	12	3	3	2	3	1	0	1	4	4	4	3	3	3	2	1	3	3	1	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:75276926G>T	uc002fdv.2	-	2	198	c.75C>A	c.(73-75)CGC>CGA	p.R25R	BCAR1_uc010cgu.2_5'UTR|BCAR1_uc010vna.1_Silent_p.R23R|BCAR1_uc010vnb.1_Silent_p.R71R|BCAR1_uc002fdw.2_Silent_p.R25R|BCAR1_uc010vnc.1_Silent_p.R25R|BCAR1_uc010vnd.1_Silent_p.R43R|BCAR1_uc002fdx.2_Silent_p.R43R	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	25	SH3.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGTCACCCTTGCGGAAGGAGA	0.627													7	44					2.0095e-06	4.05128e-06	1	0	T	75276926	T	T	75276926	2	4	223	1	0	0	0	0	0	0	0	1	1350	1306	46	4		4	BCAR1	16	75276926	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	7359369	75276926	15077827	175	41069											
PKD1L2	114780	broad.mit.edu	37	chr16	81253869	81253869	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaattcatagcaagcatctCtgaaggccacctggctgtta	12	10	8	11	0	2	1	1	1	1	0	3	1	2	1	2	2	2	4	2	2	5	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr16:81253869C>T	uc002fgh.1	-	1	107	c.107G>A	c.(106-108)AGA>AAA	p.R36K	PKD1L2_uc002fgj.2_Missense_Mutation_p.R36K	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	36	Extracellular (Potential).|C-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCAAGCATCTCTGAAGGCCAC	0.562													15	70					0	0	0	0	T	81253869	T	T	81253869	3	4	223	1	0	0	0	0	1	0	0	0	12020	913	32	2	7513	2	PKD1L2	16	81253869	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	5976943	81253869	9100884	176	41070											
RPH3AL	9501	broad.mit.edu	37	chr17	171088	171088	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctctgctgctccaggacgtCgagccgctctgccctctgga	4	10	11	16	3	3	0	0	0	3	0	6	3	4	2	3	2	4	3	3	2	0	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:171088C>T	uc002frd.1	-	2	240	c.196G>A	c.(196-198)GAC>AAC	p.D66N	RPH3AL_uc010vpy.1_Missense_Mutation_p.D66N|RPH3AL_uc002fre.1_Missense_Mutation_p.D66N|RPH3AL_uc002frf.1_Missense_Mutation_p.D66N|RPH3AL_uc010cjl.1_Missense_Mutation_p.D66N	NM_006987	NP_008918	Q9UNE2	RPH3L_HUMAN	rabphilin 3A-like (without C2 domains)	66	RabBD.				exocytosis|intracellular protein transport	transport vesicle membrane	cytoskeletal protein binding|Rab GTPase binding|zinc ion binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.023)|all cancers(1;4.96e-06)|Epithelial(1;2.86e-05)|BRCA - Breast invasive adenocarcinoma(1;0.00453)|OV - Ovarian serous cystadenocarcinoma(1;0.0716)|LUAD - Lung adenocarcinoma(1115;0.102)|COAD - Colon adenocarcinoma(4;0.107)		TCCAGGACGTCGAGCCGCTCT	0.682													29	75					0	0	0	0	T	171088	T	T	171088	3	4	223	1	0	0	0	0	1	0	0	0	13617	884	31	1	779	1	RPH3AL	17	171088	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08		171088	81024122	177	41071											
MYO1C	4641	broad.mit.edu	37	chr17	1375450	1375450	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcattgggtttgatgcagcGgacgtaggcgggctccttag	7	11	15	8	3	1	1	1	1	0	0	2	2	2	2	1	4	2	4	1	4	2	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:1375450G>A	uc002fsp.2	-	18	2090	c.1870C>T	c.(1870-1872)CGC>TGC	p.R624C	MYO1C_uc002fsn.2_Missense_Mutation_p.R605C|MYO1C_uc002fso.2_Missense_Mutation_p.R589C|MYO1C_uc010vqj.1_Missense_Mutation_p.R589C|MYO1C_uc010vqk.1_Missense_Mutation_p.R600C	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	624	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TTGATGCAGCGGACGTAGGCG	0.657													5	112					0	0	0	0	A	1375450	A	A	1375450	3	1	223	1	0	0	0	0	1	0	0	0	10123	1116	39	1	1381	1	MYO1C	17	1375450	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	1204362	1375450	79819760	178	41072											
TP53	7157	broad.mit.edu	37	chr17	7578419	7578420	+	Nonsense_Mutation	DNP	CC	AA	AA																															ggggcagcgcctcacaacctCcgtcatgtgctgtgactgct																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:7578419_7578420CC>AA	uc002gim.2	-	5	704_705	c.510_511GG>TT	c.(508-513)ACGGAG>ACTTAG	p.E171*	TP53_uc002gig.1_Nonsense_Mutation_p.E171*|TP53_uc002gih.2_Nonsense_Mutation_p.E171*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E39*|TP53_uc010cng.1_Nonsense_Mutation_p.E39*|TP53_uc002gii.1_Nonsense_Mutation_p.E39*|TP53_uc010cnh.1_Nonsense_Mutation_p.E171*|TP53_uc010cni.1_Nonsense_Mutation_p.E171*|TP53_uc002gij.2_Nonsense_Mutation_p.E171*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.E78*|TP53_uc002gio.2_Nonsense_Mutation_p.E39*|TP53_uc010vug.1_Nonsense_Mutation_p.E132*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	171	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E171*(10)|p.E171K(8)|p.0?(7)|p.T170T(7)|p.E171G(3)|p.E171Q(3)|p.E171fs*10(3)|p.E171fs*3(2)|p.E171V(2)|p.E171D(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.E171fs*9(1)|p.T170fs*2(1)|p.E171fs*1(1)|p.T170fs*8(1)|p.E171_V172delEV(1)|p.H168fs*69(1)|p.T170_E171insXX(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.E171A(1)|p.H168fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCACAACCTCCGTCATGTGCT	0.658		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	26					0	0	0	0	AA	7578420	AA	AA	7578419	4	1	223	1	0	0	0	0	0	1	0	0	16448	864	30	2	787	2	TP53	17	7578419	Nonsense_Mutation	DNP	CC	TCGA-CV-7101-01A-11D-2012-08	6202969	7578419	73616791	179	41073											
MAPK7	5598	broad.mit.edu	37	chr17	19286398	19286398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttcccctgcagccaggcaGattcagcctctctctcagcc	6	9	7	19	0	3	1	2	0	2	1	6	1	4	1	6	1	4	2	6	1	0	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:19286398G>A	uc002gvn.2	+	7	2691	c.2305G>A	c.(2305-2307)GAT>AAT	p.D769N	MAPK7_uc002gvo.2_Missense_Mutation_p.D630N|MAPK7_uc002gvq.2_Missense_Mutation_p.D769N|MAPK7_uc002gvp.2_Missense_Mutation_p.D769N|uc010vyt.1_5'Flank	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	769	May not be required for kinase activity; required to stimulate MEF2C activity (By similarity).				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					CAGCCAGGCAGATTCAGCCTC	0.597													28	78					0	0	0	0	A	19286398	A	A	19286398	3	1	223	1	0	0	0	0	1	0	0	0	9335	942	33	2	2327	2	MAPK7	17	19286398	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	11707979	19286398	61908812	180	41074											
SLC47A2	146802	broad.mit.edu	37	chr17	19610064	19610064	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccccagtcctgcaggcactgGctggaccaacctggaaacag	10	5	11	15	0	0	0	0	0	0	0	1	2	1	2	5	4	3	3	5	4	2	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:19610064G>A	uc002gwe.3	-	9	1021	c.846C>T	c.(844-846)AGC>AGT	p.S282S	SLC47A2_uc002gwg.3_Silent_p.S246S|SLC47A2_uc002gwf.3_Silent_p.S246S|SLC47A2_uc002gwh.3_RNA|SLC47A2_uc002gwi.2_RNA|SLC47A2_uc010cqs.1_RNA|SLC47A2_uc010cqt.1_RNA	NM_152908	NP_690872	Q86VL8	S47A2_HUMAN	solute carrier family 47, member 2 isoform 1	282	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					GCAGGCACTGGCTGGACCAAC	0.612													19	53					0	0	0	0	A	19610064	A	A	19610064	2	1	223	1	0	0	0	0	0	0	0	1	14712	1194	42	4		4	SLC47A2	17	19610064	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	323666	19610064	61585146	181	41075											
CDK12	51755	broad.mit.edu	37	chr17	37673784	37673784	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaccgaagaagcaatatcgaAggcgtctacgagaagaattc	17	6	10	8	4	1	3	0	0	1	3	3	6	1	3	1	1	3	1	1	1	9	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:37673784A>G	uc010cvv.2	+	10	3524	c.2938A>G	c.(2938-2940)AGG>GGG	p.R980G	CDK12_uc010wef.1_Missense_Mutation_p.R979G|CDK12_uc002hrw.3_Missense_Mutation_p.R980G	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	980	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GCAATATCGAAGGCGTCTACG	0.473										TCGA Ovarian(9;0.13)			26	88					0	0	0	0	G	37673784	G	G	37673784	3	3	223	1	0	0	0	0	1	0	0	0	3143	63	3	5	2976	5	CDK12	17	37673784	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08	18063720	37673784	43521426	182	41076											
KRTAP9-9	81870	broad.mit.edu	37	chr17	39412084	39412084	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctgctgtgagaccacctgCtgcaggaccacttgcttcca	7	9	10	15	0	0	1	0	1	0	1	1	3	1	2	5	1	4	4	5	1	0	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:39412084C>A	uc010wfq.1	+	3	404	c.402C>A	c.(400-402)TGC>TGA	p.C134*		NM_030975	NP_112237	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	149						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			AGACCACCTGCTGCAGGACCA	0.602													78	170					3.54697e-40	7.91368e-40	1	0	A	39412084	A	A	39412084	4	1	223	1	0	0	0	0	0	1	0	0	8617	805	28	4	449	4	KRTAP9-9	17	39412084	Nonsense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	1738300	39412084	41783126	183	41077											
KRT36	8689	broad.mit.edu	37	chr17	39644611	39644611	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctacgcaggccgttgatgtCggcctccactagctgccgca	6	8	11	16	4	0	1	0	1	0	0	2	1	1	1	5	2	3	4	5	2	2	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:39644611C>T	uc002hwt.2	-	3	583	c.583G>A	c.(583-585)GAC>AAC	p.D195N		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	195	Rod.|Coil 1B.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				CCGTTGATGTCGGCCTCCACT	0.592													40	70					0	0	0	0	T	39644611	T	T	39644611	3	4	223	1	0	0	0	0	1	0	0	0	8512	884	31	1	840	1	KRT36	17	39644611	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	232527	39644611	41550599	184	41078											
CNTNAP1	8506	broad.mit.edu	37	chr17	40847632	40847632	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagttctcccacatgctgaGccggccagtgccaggctatg	7	8	13	13	1	1	1	0	1	1	0	2	2	1	2	4	3	3	3	4	3	1	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:40847632G>T	uc002iay.2	+	19	3302	c.3086G>T	c.(3085-3087)AGC>ATC	p.S1029I	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	1029	Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		CACATGCTGAGCCGGCCAGTG	0.617													9	84					0.000274275	0.00052552	1	0	T	40847632	T	T	40847632	3	4	223	1	0	0	0	0	1	0	0	0	3661	971	34	4	3160	4	CNTNAP1	17	40847632	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	1203021	40847632	40347578	185	41079											
GPATCH8	23131	broad.mit.edu	37	chr17	42478140	42478140	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcttgggagaactgcctttTttactctctggggcattctt	5	16	11	9	0	2	1	0	0	2	1	3	2	2	1	1	4	3	2	1	4	2	6	rs143765658	byFrequency	TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:42478140T>G	uc002igw.1	-	8	1369	c.1305A>C	c.(1303-1305)AAA>AAC	p.K435N	GPATCH8_uc002igv.1_Missense_Mutation_p.K357N|GPATCH8_uc010wiz.1_Missense_Mutation_p.K357N	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	435						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		AACTGCCTTTTTTACTCTCTG	0.443											OREG0024461	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	181					0	0	0	0	G	42478140	G	G	42478140	3	3	223	1	0	0	0	0	1	0	0	0	6632	1838	64	5	3207	5	GPATCH8	17	42478140	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	1630508	42478140	38717070	186	41080											
CBX1	10951	broad.mit.edu	37	chr17	46153470	46153470	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctcatgtgctgttttctGtgactgcagaaactcagcaa	9	14	9	9	0	3	2	2	1	2	1	4	2	3	2	0	0	4	4	0	0	2	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:46153470G>A	uc002ind.3	-	3	692	c.211C>T	c.(211-213)CAG>TAG	p.Q71*	CBX1_uc002ine.3_Nonsense_Mutation_p.Q71*	NM_006807	NP_006798	P83916	CBX1_HUMAN	heterochromatin protein 1-beta	71	Chromo 1.					nuclear heterochromatin|nucleoplasm|spindle	chromatin binding|enzyme binding				0						GCTGTTTTCTGTGACTGCAGA	0.403													15	74					0	0	0	0	A	46153470	A	A	46153470	4	1	223	1	0	0	0	0	0	1	0	0	2729	1386	48	4	358	4	CBX1	17	46153470	Nonsense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	3675330	46153470	35041740	187	41081											
TBCD	6904	broad.mit.edu	37	chr17	80865685	80865685	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagtgcagggcctgaagcaGattcaccagcaggtttgtgt	9	9	14	9	0	1	2	1	1	0	1	1	2	1	2	2	2	3	5	2	2	1	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr17:80865685G>A	uc002kfz.2	+	21	2101	c.1971G>A	c.(1969-1971)CAG>CAA	p.Q657Q	TBCD_uc002kfx.1_Silent_p.Q640Q|TBCD_uc002kfy.1_Silent_p.Q657Q|TBCD_uc002kgb.1_5'UTR	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	657					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			GCCTGAAGCAGATTCACCAGC	0.617													4	13					0	0	0	0	A	80865685	A	A	80865685	2	1	223	1	0	0	0	0	0	0	0	1	15699	933	33	2		2	TBCD	17	80865685	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	34712215	80865685	329525	188	41082											
ZFP161	7541	broad.mit.edu	37	chr18	5291434	5291434	+	Missense_Mutation	SNP	G	C	C																															acttcatgtcactggcggctGttgtccagcctggtgtctgt																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr18:5291434G>C	uc002kmq.2	-	4	934	c.773C>G	c.(772-774)ACA>AGA	p.T258R	ZFP161_uc002kmr.2_Missense_Mutation_p.T258R|ZFP161_uc010dkp.2_Missense_Mutation_p.T258R	NM_003409	NP_003400	O43829	ZF161_HUMAN	zinc finger protein 161 homolog	258					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACTGGCGGCTGTTGTCCAGCC	0.493													32	110					0	0	0	0	C	5291434	C	C	5291434	3	2	223	1	0	0	0	0	1	0	0	0	17707	1377	48	4	580	4	ZFP161	18	5291434	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08		5291434	72785814	189	41083	85	2									
ZFP161	7541	broad.mit.edu	37	chr18	5291439	5291439	+	Missense_Mutation	SNP	C	G	G																															atgtcactggcggctgttgtCcagcctggtgtctgttcatc																										TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr18:5291439C>G	uc002kmq.2	-	4	929	c.768G>C	c.(766-768)TGG>TGC	p.W256C	ZFP161_uc002kmr.2_Missense_Mutation_p.W256C|ZFP161_uc010dkp.2_Missense_Mutation_p.W256C	NM_003409	NP_003400	O43829	ZF161_HUMAN	zinc finger protein 161 homolog	256					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CGGCTGTTGTCCAGCCTGGTG	0.493													33	115					0	0	0	0	G	5291439	G	G	5291439	3	3	223	1	0	0	0	0	1	0	0	0	17707	856	30	2	585	2	ZFP161	18	5291439	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	5	5291439	72785809	190	41084	85	2									
EPB41L3	23136	broad.mit.edu	37	chr18	5394794	5394794	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taattgcctgagccagcgccTatccccgggaaatcacagaa	12	7	9	13	2	1	2	1	1	0	1	2	3	2	3	5	1	3	0	5	1	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr18:5394794T>A	uc002kmt.1	-	22	3240	c.3154_splice	c.e22-1	p.A1052_splice	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Splice_Site_p.A830_splice|EPB41L3_uc010dkq.1_Splice_Site_p.A721_splice|EPB41L3_uc002kms.1_Splice_Site_p.A287_splice|EPB41L3_uc010wze.1_Splice_Site_p.A357_splice|EPB41L3_uc010wzf.1_Splice_Site_p.A349_splice|EPB41L3_uc010wzg.1_Splice_Site_p.A324_splice|EPB41L3_uc010dkr.2_Splice_Site_p.A444_splice	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3						cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						AGCCAGCGCCTATCCCCGGGA	0.473													62	64					0	0	0	0	A	5394794	A	A	5394794	5	1	223	1	0	0	0	0	0	0	1	0	5178	1536	53	5	115	5	EPB41L3	18	5394794	Splice_Site	SNP	T	TCGA-CV-7101-01A-11D-2012-08	103355	5394794	72682454	191	41085											
CELF4	56853	broad.mit.edu	37	chr18	34855109	34855109	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcgggcccgcgcaggatGgtgcactcctcgatgttccc	4	8	13	16	5	0	0	0	0	0	0	4	2	2	1	4	3	1	3	4	3	0	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr18:34855109G>T	uc002lae.2	-	4	942	c.546C>A	c.(544-546)ACC>ACA	p.T182T	CELF4_uc010dnd.1_Silent_p.T181T|CELF4_uc002lag.2_Silent_p.T172T|CELF4_uc002laf.2_Silent_p.T177T|CELF4_uc002lai.2_Silent_p.T167T|CELF4_uc002lah.1_5'Flank|CELF4_uc002laj.1_5'Flank	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	182	Sufficient for RNA-binding and MSE- dependent splicing activity.|RRM 2.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						CGCGCAGGATGGTGCACTCCT	0.662													8	81					1.12685e-05	2.23589e-05	1	0	T	34855109	T	T	34855109	2	4	223	1	0	0	0	0	0	0	0	1	3233	1335	47	4		4	CELF4	18	34855109	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	29460315	34855109	43222139	192	41086											
ZCCHC2	54877	broad.mit.edu	37	chr18	60242731	60242731	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgttacaattgtggtgtaagCggacactatgcacaggactg	11	11	12	7	1	0	0	0	0	0	0	0	2	0	2	0	3	3	3	0	3	4	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr18:60242731C>T	uc002lip.3	+	13	3417	c.3417C>T	c.(3415-3417)AGC>AGT	p.S1139S	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Silent_p.S609S	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	1139	CCHC-type.				cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						GTGGTGTAAGCGGACACTATG	0.458													9	25					0	0	0	0	T	60242731	T	T	60242731	2	4	223	1	0	0	0	0	0	0	0	1	17654	767	27	1		1	ZCCHC2	18	60242731	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	25387622	60242731	17834517	193	41087											
PARD6G	84552	broad.mit.edu	37	chr18	77917833	77917833	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaggctgcctgcgggcgCgcccggggtctgggggggac	3	4	23	11	4	1	1	0	0	1	1	1	3	1	2	2	8	2	1	2	8	0	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	44de281e-3382-4bfc-a40b-45f8797b9570	g.chr18:77917833C>T	uc002lny.2	-	3	1118	c.952G>A	c.(952-954)GCG>ACG	p.A318T	LOC100130522_uc002lnx.2_Intron|LOC100130522_uc010xfn.1_Intron|LOC100130522_uc010xfo.1_Intron	NM_032510	NP_115899	Q9BYG4	PAR6G_HUMAN	PAR-6 gamma protein	318					cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding				0		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)		CCTGCGGGCGCGCCCGGGGTC	0.731													3	5					0	0	0	0	T	77917833	T	T	77917833	3	4	223	1	0	0	0	0	1	0	0	0	11501	768	27	1	182	1	PARD6G	18	77917833	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	17675102	77917833	159415	194	41088											
XAB2	56949	broad.mit.edu	37	chr19	7685195	7685195	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcccgagaccttgagcatCtgcgaggccatgaagttgac	9	8	12	12	2	1	4	0	3	1	1	1	6	1	4	3	1	3	2	3	1	1	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:7685195C>A	uc002mgx.2	-	16	2258	c.2232G>T	c.(2230-2232)CAG>CAT	p.Q744H		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	744					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						CCTTGAGCATCTGCGAGGCCA	0.627								Direct_reversal_of_damage|NER					6	43					3.59834e-05	7.08378e-05	1	0	A	7685195	A	A	7685195	3	1	223	1	0	0	0	0	1	0	0	0	17486	912	32	2	351	2	XAB2	19	7685195	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08		7685195	51443788	195	41089											
TIMM44	10469	broad.mit.edu	37	chr19	7997752	7997752	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcggtgaccttgtccgtaaGggcccgggatgcccggatga	6	8	16	11	4	0	2	0	2	0	0	2	4	1	4	4	4	1	1	4	4	1	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:7997752G>A	uc002miz.2	-	8	837	c.835C>T	c.(835-837)CTT>TTT	p.L279F	TIMM44_uc002mja.2_Missense_Mutation_p.L19F|TIMM44_uc010dvx.1_RNA	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	279					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						TTGTCCGTAAGGGCCCGGGAT	0.632													4	84					0	0	0	0	A	7997752	A	A	7997752	3	1	223	1	0	0	0	0	1	0	0	0	15978	1000	35	4	547	4	TIMM44	19	7997752	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	312557	7997752	51131231	196	41090											
FBN3	84467	broad.mit.edu	37	chr19	8148207	8148207	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaggagccaaggctgttgatGcactccccatgagcacacag	12	6	11	12	0	0	2	0	2	0	0	1	3	1	3	3	2	3	4	3	2	2	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:8148207G>T	uc002mjf.2	-	56	7158	c.7137C>A	c.(7135-7137)TGC>TGA	p.C2379*	FBN3_uc002mje.2_Nonsense_Mutation_p.C218*	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2379	EGF-like 38; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGCTGTTGATGCACTCCCCAT	0.597													16	64					1.5739e-10	3.27841e-10	1	0	T	8148207	T	T	8148207	4	4	223	1	0	0	0	0	0	1	0	0	5736	1311	46	4	1324	4	FBN3	19	8148207	Nonsense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	150455	8148207	50980776	197	41091											
OR7D2	162998	broad.mit.edu	37	chr19	9296822	9296822	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaccgtgatggcctatgaccGgtttgtggctgtctgccacc	5	11	13	12	2	1	2	0	2	1	0	1	3	1	2	5	3	1	2	5	3	1	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:9296822G>A	uc002mkz.1	+	1	553	c.365G>A	c.(364-366)CGG>CAG	p.R122Q		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	122	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						GCCTATGACCGGTTTGTGGCT	0.502													11	140					0	0	0	0	A	9296822	A	A	9296822	3	1	223	1	0	0	0	0	1	0	0	0	11273	1116	39	1	367	1	OR7D2	19	9296822	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	1148615	9296822	49832161	198	41092											
TMEM161A	54929	broad.mit.edu	37	chr19	19243544	19243544	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagacagtggcttctcctCactaaggccattggcccacc	9	8	8	16	0	2	1	1	0	1	1	3	1	2	1	4	3	0	1	4	3	1	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:19243544C>T	uc002nlg.2	-	4	238	c.208G>A	c.(208-210)GAG>AAG	p.E70K	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Missense_Mutation_p.E70K|TMEM161A_uc002nli.2_Missense_Mutation_p.E70K|TMEM161A_uc002nlj.2_5'UTR	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	70	Extracellular (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			GGCTTCTCCTCACTAAGGCCA	0.627													4	27					0	0	0	0	T	19243544	T	T	19243544	3	4	223	1	0	0	0	0	1	0	0	0	16142	835	29	2	1267	2	TMEM161A	19	19243544	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	9946722	19243544	39885439	199	41093											
ZNF100	163227	broad.mit.edu	37	chr19	21909734	21909734	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaggctttgccacattcGtcacatttgtagggtttctc	8	16	8	9	1	2	0	1	0	1	0	4	0	2	0	1	2	1	3	1	2	3	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:21909734G>T	uc002nqi.2	-	5	1579	c.1380C>A	c.(1378-1380)GAC>GAA	p.D460E	ZNF100_uc002nqh.2_Missense_Mutation_p.D396E	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	460	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCCACATTCGTCACATTTGT	0.408													11	89					6.40141e-05	0.000125039	1	0	T	21909734	T	T	21909734	3	4	223	1	0	0	0	0	1	0	0	0	17780	1136	40	3	252	3	ZNF100	19	21909734	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	2666190	21909734	37219249	200	41094											
ZNF208	7757	broad.mit.edu	37	chr19	22156525	22156525	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttatgttccataaggtttgaGgaccagttgaaagctttgcc	10	14	10	7	0	0	2	0	2	0	0	1	3	1	3	3	2	2	4	3	2	3	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:22156525G>A	uc002nqp.2	-	4	1460	c.1311C>T	c.(1309-1311)TCC>TCT	p.S437S	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAAGGTTTGAGGACCAGTTGA	0.378													24	75					0	0	0	0	A	22156525	A	A	22156525	2	1	223	1	0	0	0	0	0	0	0	1	17833	987	35	4		4	ZNF208	19	22156525	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	246791	22156525	36972458	201	41095											
ZNF208	7757	broad.mit.edu	37	chr19	22156838	22156838	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttctctccagcatgaattGccttatgtgtaataagggtt	9	15	9	8	0	1	1	0	1	1	0	3	1	2	1	2	1	2	4	2	1	4	6			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:22156838G>A	uc002nqp.2	-	4	1147	c.998C>T	c.(997-999)GCA>GTA	p.A333V	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGCATGAATTGCCTTATGTGT	0.393													42	59					0	0	0	0	A	22156838	A	A	22156838	3	1	223	1	0	0	0	0	1	0	0	0	17833	1319	46	4	2848	4	ZNF208	19	22156838	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	313	22156838	36972145	202	41096											
ZNF254	9534	broad.mit.edu	37	chr19	24310294	24310294	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtgaagaatgtggcaaaTcttttagccaatcctcaacc	14	11	7	9	0	2	2	1	1	1	1	3	2	3	2	3	1	2	1	3	1	7	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:24310294T>G	uc002nru.2	+	4	1626	c.1492T>G	c.(1492-1494)TCT>GCT	p.S498A	ZNF254_uc010xrk.1_Missense_Mutation_p.S413A	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	498	C2H2-type 11.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATGTGGCAAATCTTTTAGCCA	0.408													3	72					0	0	0	0	G	24310294	G	G	24310294	3	3	223	1	0	0	0	0	1	0	0	0	17865	1435	50	5	1506	5	ZNF254	19	24310294	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08	2153456	24310294	34818689	203	41097											
PLEKHF1	79156	broad.mit.edu	37	chr19	30165036	30165036	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccggagacgctgcaggccaAgaaccgctggatgatcaaga	12	4	14	11	3	1	4	1	1	0	3	1	6	1	5	3	3	2	3	3	3	3	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:30165036A>C	uc002nsh.3	+	2	392	c.290A>C	c.(289-291)AAG>ACG	p.K97T	PLEKHF1_uc002nsi.3_Missense_Mutation_p.K182T	NM_024310	NP_077286	Q96S99	PKHF1_HUMAN	apoptosis-inducing protein D	97	PH.				apoptosis	lysosome|nucleus|perinuclear region of cytoplasm	metal ion binding				0	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			CTGCAGGCCAAGAACCGCTGG	0.602													22	27					0	0	0	0	C	30165036	C	C	30165036	3	2	223	1	0	0	0	0	1	0	0	0	12121	72	3	5	292	5	PLEKHF1	19	30165036	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08	5854742	30165036	28963947	204	41098											
ZNF536	9745	broad.mit.edu	37	chr19	31039643	31039643	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaccatcggggtcacagtCaactgcaaagaccaagcccg	14	4	9	14	2	2	1	2	0	0	1	3	1	2	1	3	2	4	1	3	2	4	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:31039643C>A	uc002nsu.1	+	4	3255	c.3117C>A	c.(3115-3117)GTC>GTA	p.V1039V	ZNF536_uc010edd.1_Silent_p.V1039V	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1039					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGGTCACAGTCAACTGCAAAG	0.542													17	45					3.52763e-06	7.05526e-06	1	0	A	31039643	A	A	31039643	2	1	223	1	0	0	0	0	0	0	0	1	18041	813	29	2		2	ZNF536	19	31039643	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	874607	31039643	28089340	205	41099											
DMPK	1760	broad.mit.edu	37	chr19	46280797	46280797	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcaaccgctgaatgaagtCtcgagcctcctcagggaccc	10	6	10	15	2	2	2	1	2	1	0	4	4	3	3	4	1	3	2	4	1	3	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:46280797C>T	uc002pdd.1	-	7	1508	c.964G>A	c.(964-966)GAC>AAC	p.D322N	DMPK_uc010xxs.1_Missense_Mutation_p.D223N|DMPK_uc002pde.1_Missense_Mutation_p.D322N|DMPK_uc002pdf.1_Missense_Mutation_p.D312N|DMPK_uc002pdg.1_Missense_Mutation_p.D312N|DMPK_uc002pdh.1_Missense_Mutation_p.D312N|DMPK_uc002pdi.1_Missense_Mutation_p.D338N|DMPK_uc010xxt.1_Missense_Mutation_p.D312N	NM_001081563	NP_001075032	Q09013	DMPK_HUMAN	myotonic dystrophy protein kinase isoform 1	322	Protein kinase.				regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)	3		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		TGAATGAAGTCTCGAGCCTCC	0.652													11	59					0	0	0	0	T	46280797	T	T	46280797	3	4	223	1	0	0	0	0	1	0	0	0	4606	913	32	2	994	2	DMPK	19	46280797	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	15241154	46280797	12848186	206	41100											
LHB	3972	broad.mit.edu	37	chr19	49519449	49519449	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agctgagagccacagggaagGagaccacggggtccacacca	13	2	14	12	1	0	2	0	1	0	2	1	5	1	3	4	4	2	1	4	4	1	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:49519449G>A	uc002plt.2	-	3	311	c.302C>T	c.(301-303)TCC>TTC	p.S101F		NM_000894	NP_000885	P01229	LSHB_HUMAN	luteinizing hormone beta subunit precursor	101					cell-cell signaling|cellular nitrogen compound metabolic process|male gonad development|peptide hormone processing|progesterone biosynthetic process|signal transduction	extracellular region|soluble fraction	hormone activity				0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Lutropin alfa(DB00044)|Menotropins(DB00032)	CACAGGGAAGGAGACCACGGG	0.672													5	104					0	0	0	0	A	49519449	A	A	49519449	3	1	223	1	0	0	0	0	1	0	0	0	8802	1174	41	2	127	2	LHB	19	49519449	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	3238652	49519449	9609534	207	41101											
CPT1C	126129	broad.mit.edu	37	chr19	50209265	50209265	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaaacagcctgctttcccCgagagccctggagcagcagt	9	6	11	15	2	0	1	0	0	0	1	1	4	1	2	5	1	6	3	5	1	1	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:50209265C>A	uc002ppj.2	+	10	1269	c.1064C>A	c.(1063-1065)CCG>CAG	p.P355Q	CPT1C_uc002ppl.3_Missense_Mutation_p.P321Q|CPT1C_uc002ppi.2_Missense_Mutation_p.P272Q|CPT1C_uc002ppk.2_Missense_Mutation_p.P344Q|CPT1C_uc010eng.2_Missense_Mutation_p.P355Q|CPT1C_uc010enh.2_Missense_Mutation_p.P355Q|CPT1C_uc010ybc.1_Missense_Mutation_p.P226Q|CPT1C_uc010eni.1_Missense_Mutation_p.P12Q	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	355	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CTGCTTTCCCCGAGAGCCCTG	0.612													4	69					0.00024832	0.000477612	1	0	A	50209265	A	A	50209265	3	1	223	1	0	0	0	0	1	0	0	0	3848	652	23	3	1098	3	CPT1C	19	50209265	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	689816	50209265	8919718	208	41102											
ZNF701	55762	broad.mit.edu	37	chr19	53086647	53086647	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtgtaatgaatgtggcaaGgtttttaatcgaaaatcaaa	17	12	9	3	1	1	1	1	1	0	0	2	2	1	1	0	2	0	3	0	2	8	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:53086647G>T	uc002pzs.1	+	4	1462	c.1335G>T	c.(1333-1335)AAG>AAT	p.K445N	ZNF701_uc010ydn.1_Missense_Mutation_p.K511N	NM_018260	NP_060730	Q9NV72	ZN701_HUMAN	zinc finger protein 701	445	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		AATGTGGCAAGGTTTTTAATC	0.348													17	33					5.03518e-11	1.05319e-10	1	0	T	53086647	T	T	53086647	3	4	223	1	0	0	0	0	1	0	0	0	18172	991	35	4	1547	4	ZNF701	19	53086647	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	2877382	53086647	6042336	209	41103											
LILRA5	353514	broad.mit.edu	37	chr19	54823182	54823182	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggctctgaccagcctgcagGgctgtagtagtaacagcggt	8	8	15	10	1	1	1	0	1	1	0	1	1	1	1	2	3	4	6	2	3	3	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:54823182G>A	uc002qfe.2	-	4	481	c.361C>T	c.(361-363)CCT>TCT	p.P121S	LILRA5_uc002qff.2_Missense_Mutation_p.P109S|LILRA5_uc010yev.1_Missense_Mutation_p.P121S|LILRA5_uc010yew.1_Missense_Mutation_p.P109S|LILRA5_uc002qfh.1_Missense_Mutation_p.P109S|LILRA5_uc002qfg.1_Missense_Mutation_p.P121S	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	121	Extracellular (Potential).|Ig-like C2-type 1.				innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGCCTGCAGGGCTGTAGTAG	0.612													48	141					0	0	0	0	A	54823182	A	A	54823182	3	1	223	1	0	0	0	0	1	0	0	0	8829	1232	43	4	640	4	LILRA5	19	54823182	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	1736535	54823182	4305801	210	41104											
KIR2DL1	3802	broad.mit.edu	37	chr19	55286879	55286879	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccatacgagtggtcaaaGtcaagtgacccactgcttgt	10	11	9	11	1	3	1	2	1	1	0	4	2	3	1	2	1	2	1	2	1	3	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:55286879G>T	uc002qhb.1	+	4	671	c.633G>T	c.(631-633)AAG>AAT	p.K211N	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_RNA|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.K211N	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	211	Extracellular (Potential).				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		AGTGGTCAAAGTCAAGTGACC	0.547													14	188					0.000308642	0.000589119	1	0	T	55286879	T	T	55286879	3	4	223	1	0	0	0	0	1	0	0	0	8355	1020	36	4	647	4	KIR2DL1	19	55286879	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	463697	55286879	3842104	211	41105											
FCAR	2204	broad.mit.edu	37	chr19	55399565	55399565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctttgggtcctgtggacCtcaatgtctcagggatctac	6	14	10	11	0	4	0	2	0	3	0	7	2	5	2	2	3	1	0	2	3	2	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:55399565C>T	uc002qhr.1	+	4	750	c.553C>T	c.(553-555)CTC>TTC	p.L185F	FCAR_uc002qhq.2_Missense_Mutation_p.L185F|FCAR_uc002qhs.1_Intron|FCAR_uc002qht.1_Missense_Mutation_p.L158F|FCAR_uc010esi.1_Intron|FCAR_uc002qhu.1_Intron|FCAR_uc002qhv.1_Missense_Mutation_p.L185F|FCAR_uc002qhw.1_Missense_Mutation_p.L173F|FCAR_uc002qhx.1_Intron|FCAR_uc002qhy.1_Missense_Mutation_p.L173F|FCAR_uc002qhz.1_Missense_Mutation_p.L173F|FCAR_uc002qia.1_Missense_Mutation_p.L76F	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	185	Ig-like C2-type 2.|Extracellular (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		TCCTGTGGACCTCAATGTCTC	0.537													8	17					0	0	0	0	T	55399565	T	T	55399565	3	4	223	1	0	0	0	0	1	0	0	0	5805	681	24	4	567	4	FCAR	19	55399565	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	112686	55399565	3729418	212	41106											
NLRP2	55655	broad.mit.edu	37	chr19	55501499	55501499	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgacaatgagcttctggatGagggtgctaagttgctgtac	9	11	13	8	1	1	2	0	2	1	0	1	4	1	3	1	2	4	5	1	2	3	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:55501499G>T	uc002qij.2	+	9	2562	c.2476G>T	c.(2476-2478)GAG>TAG	p.E826*	NLRP2_uc010yfp.1_Nonsense_Mutation_p.E803*|NLRP2_uc010esn.2_Nonsense_Mutation_p.E802*|NLRP2_uc010eso.2_Nonsense_Mutation_p.E823*|NLRP2_uc010esp.2_Nonsense_Mutation_p.E804*	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	826	LRR 1.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GCTTCTGGATGAGGGTGCTAA	0.517													19	65					3.70931e-20	8.06094e-20	1	0	T	55501499	T	T	55501499	4	4	223	1	0	0	0	0	0	1	0	0	10531	1291	45	2	2506	2	NLRP2	19	55501499	Nonsense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	101934	55501499	3627484	213	41107											
NLRP9	338321	broad.mit.edu	37	chr19	56220313	56220313	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgatcttgtattcctcgtCaatccaaggtccatgtgaaa	10	13	7	11	1	2	2	1	2	1	0	6	2	5	2	4	1	0	1	4	1	4	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:56220313C>G	uc002qly.2	-	9	2969	c.2941G>C	c.(2941-2943)GAC>CAC	p.D981H		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	981						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TATTCCTCGTCAATCCAAGGT	0.488													9	72					0	0	0	0	G	56220313	G	G	56220313	3	3	223	1	0	0	0	0	1	0	0	0	10538	826	29	2	38	2	NLRP9	19	56220313	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	718814	56220313	2908670	214	41108											
PEG3	5178	broad.mit.edu	37	chr19	57327825	57327825	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaataaaggtttcctcaCacactttacccttgttttca	11	14	5	11	0	2	0	2	0	0	0	3	1	3	1	2	2	1	2	2	2	4	7			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr19:57327825C>A	uc002qnu.2	-	7	2336	c.1985G>T	c.(1984-1986)TGT>TTT	p.C662F	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.C633F|PEG3_uc002qnv.2_Missense_Mutation_p.C662F|PEG3_uc002qnw.2_Missense_Mutation_p.C538F|PEG3_uc002qnx.2_Missense_Mutation_p.C536F|PEG3_uc010etr.2_Missense_Mutation_p.C662F	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	662					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GGTTTCCTCACACACTTTACC	0.438													27	91					1.26454e-06	2.55968e-06	1	0	A	57327825	A	A	57327825	3	1	223	1	0	0	0	0	1	0	0	0	11774	478	17	4	2785	4	PEG3	19	57327825	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	1107512	57327825	1801158	215	41109											
THBD	7056	broad.mit.edu	37	chr20	23029759	23029759	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggccgcagaggggagccccaTtgaggtcgagccgtgcccac	7	4	16	14	3	0	2	0	1	0	1	1	4	0	3	5	4	3	1	5	4	0	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr20:23029759T>C	uc002wss.2	-	1	543	c.383A>G	c.(382-384)AAT>AGT	p.N128S	THBD_uc002wst.1_5'Flank|THBD_uc002wsu.1_Missense_Mutation_p.N69S	NM_000361	NP_000352	P07204	TRBM_HUMAN	thrombomodulin precursor	128	C-type lectin.|Extracellular (Potential).				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity				0	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	GGGAGCCCCATTGAGGTCGAG	0.677													3	8					0	0	0	0	C	23029759	C	C	23029759	3	2	223	1	0	0	0	0	1	0	0	0	15918	1493	52	5	1348	5	THBD	20	23029759	Missense_Mutation	SNP	T	TCGA-CV-7101-01A-11D-2012-08		23029759	39995761	216	41110											
ACSS2	55902	broad.mit.edu	37	chr20	33470765	33470765	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgaaatgtccatgagaaaaAgcttggagataaagttgctt	15	11	10	5	1	0	2	0	1	0	2	2	5	1	2	1	1	2	3	1	1	5	4			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr20:33470765A>T	uc002xbd.2	+	2	468	c.347A>T	c.(346-348)AAG>ATG	p.K116M	ACSS2_uc002xbc.2_Missense_Mutation_p.K21M|ACSS2_uc010zum.1_RNA|ACSS2_uc010gey.2_Missense_Mutation_p.K116M|ACSS2_uc002xbe.2_Translation_Start_Site|ACSS2_uc002xbf.2_Missense_Mutation_p.K116M	NM_018677	NP_061147	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	116					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding				0					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CATGAGAAAAAGCTTGGAGAT	0.294													4	22					0	0	0	0	T	33470765	T	T	33470765	3	4	223	1	0	0	0	0	1	0	0	0	189	72	3	5	353	5	ACSS2	20	33470765	Missense_Mutation	SNP	A	TCGA-CV-7101-01A-11D-2012-08	10441006	33470765	29554755	217	41111											
CPNE1	8904	broad.mit.edu	37	chr20	34214297	34214297	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtctgtgccaatgcctcccGaggggcctgccaagaaaagg	9	6	14	12	1	1	1	0	0	1	1	2	2	2	1	5	4	3	0	5	4	4	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr20:34214297G>A	uc002xdf.2	-	18	1843	c.1480C>T	c.(1480-1482)CGG>TGG	p.R494W	CPNE1_uc002xdc.2_Missense_Mutation_p.R156W|CPNE1_uc010zvj.1_Missense_Mutation_p.R499W|CPNE1_uc002xde.2_Missense_Mutation_p.R470W|CPNE1_uc002xdg.2_Missense_Mutation_p.R438W|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Missense_Mutation_p.R494W|CPNE1_uc002xdi.2_Missense_Mutation_p.R494W|CPNE1_uc002xdj.2_Missense_Mutation_p.R494W|CPNE1_uc002xdk.2_Missense_Mutation_p.R494W|CPNE1_uc002xdl.2_Missense_Mutation_p.R494W|CPNE1_uc002xdm.2_Missense_Mutation_p.R494W	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	494	VWFA.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			AATGCCTCCCGAGGGGCCTGC	0.572													27	67					0	0	0	0	A	34214297	A	A	34214297	3	1	223	1	0	0	0	0	1	0	0	0	3826	1057	37	1	137	1	CPNE1	20	34214297	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	743532	34214297	28811223	218	41112											
MATN4	8785	broad.mit.edu	37	chr20	43929779	43929779	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggctgcaagtcatggccCtctctgcagtggcaccgtgg	6	9	13	13	1	3	0	2	0	1	0	4	0	3	0	2	4	2	4	2	4	1	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr20:43929779C>T	uc002xnn.2	-	5	1039	c.852G>A	c.(850-852)GAG>GAA	p.E284E	MATN4_uc002xno.2_Silent_p.E243E|MATN4_uc002xnp.2_Intron|MATN4_uc010zwr.1_Silent_p.E232E|MATN4_uc002xnr.1_Silent_p.E284E	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	325	EGF-like 3.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				AGTCATGGCCCTCTCTGCAGT	0.582											OREG0025977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	51					0	0	0	0	T	43929779	T	T	43929779	2	4	223	1	0	0	0	0	0	0	0	1	9389	680	24	4		4	MATN4	20	43929779	Silent	SNP	C	TCGA-CV-7101-01A-11D-2012-08	9715482	43929779	19095741	219	41113											
DOPEY2	9980	broad.mit.edu	37	chr21	37617523	37617523	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgagaagtacccgctgcgagGcgagctgagcgaggaagagc	11	3	17	10	5	0	3	0	1	0	2	0	8	0	4	1	2	5	3	1	2	3	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr21:37617523G>A	uc002yvg.2	+	19	3324	c.3245G>A	c.(3244-3246)GGC>GAC	p.G1082D	DOPEY2_uc011aeb.1_Missense_Mutation_p.G1031D|DOPEY2_uc002yvh.2_5'UTR	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1082					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CCGCTGCGAGGCGAGCTGAGC	0.632													4	34					0	0	0	0	A	37617523	A	A	37617523	3	1	223	1	0	0	0	0	1	0	0	0	4730	1203	42	4	3315	4	DOPEY2	21	37617523	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08		37617523	10512372	220	41114											
MICAL3	57553	broad.mit.edu	37	chr22	18384651	18384651	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagaccaataccttccaaGgtgttcctccgaccatcccc	10	8	5	18	1	0	1	0	0	0	1	4	2	4	1	8	1	1	1	8	1	3	3			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr22:18384651G>A	uc002zng.3	-	5	1037	c.684C>T	c.(682-684)ACC>ACT	p.T228T	MICAL3_uc011agl.1_Silent_p.T228T|MICAL3_uc002znh.2_Silent_p.T228T|MICAL3_uc002znj.1_5'UTR|MICAL3_uc002znk.1_Silent_p.T228T|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Silent_p.T228T|MICAL3_uc011agm.1_Silent_p.T228T	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	228						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		TACCTTCCAAGGTGTTCCTCC	0.562													6	29					0	0	0	0	A	18384651	A	A	18384651	2	1	223	1	0	0	0	0	0	0	0	1	9624	987	35	4		4	MICAL3	22	18384651	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08		18384651	32919915	221	41115											
HIRA	7290	broad.mit.edu	37	chr22	19344526	19344526	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggagacggcgaccacaggtGgagaacactgacagcatcct	13	4	13	11	2	0	3	0	1	0	2	1	6	1	3	2	4	2	1	2	4	1	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr22:19344526G>T	uc002zpf.1	-	19	2503	c.2283C>A	c.(2281-2283)TCC>TCA	p.S761S	HIRA_uc011agx.1_Silent_p.S627S|HIRA_uc010grn.1_Intron|HIRA_uc010gro.1_Silent_p.S717S|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	761	Interaction with PAX3 (By similarity).|Interaction with histone H2B.|Interaction with histone H4.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					GACCACAGGTGGAGAACACTG	0.592													15	166					1.15088e-07	2.33903e-07	1	0	T	19344526	T	T	19344526	2	4	223	1	0	0	0	0	0	0	0	1	7159	1335	47	4		4	HIRA	22	19344526	Silent	SNP	G	TCGA-CV-7101-01A-11D-2012-08	959875	19344526	31960040	222	41116											
GGT5	2687	broad.mit.edu	37	chr22	24640644	24640644	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caatgacagccagcgccagcCccagacccagcaggactagg	12	2	11	16	1	0	2	0	1	0	1	0	3	0	3	5	2	4	1	5	2	2	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr22:24640644C>G	uc002zzo.3	-	1	467	c.50G>C	c.(49-51)GGG>GCG	p.G17A	GGT5_uc002zzp.3_Missense_Mutation_p.G17A|GGT5_uc002zzr.3_Missense_Mutation_p.G17A|GGT5_uc002zzq.3_Missense_Mutation_p.G17A|GGT5_uc011ajm.1_Missense_Mutation_p.G17A|GGT5_uc011ajn.1_RNA	NM_004121	NP_004112	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5 isoform b	17	Helical; Signal-anchor for type II membrane protein; (Potential).				glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(2)|skin(1)	3						CAGCGCCAGCCCCAGACCCAG	0.662													3	34					0	0	0	0	G	24640644	G	G	24640644	3	3	223	1	0	0	0	0	1	0	0	0	6399	623	22	4	1761	4	GGT5	22	24640644	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	5296118	24640644	26663922	223	41117											
DEPDC5	9681	broad.mit.edu	37	chr22	32198787	32198787	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtctttgaagtggaccgcctActcatgatcctgaccaagca	10	10	9	12	1	2	3	1	3	1	0	3	4	3	4	4	1	2	1	4	1	3	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr22:32198787A>T	uc003als.2	+	15	1186	c.1044A>T	c.(1042-1044)CTA>CTT	p.L348L	DEPDC5_uc011als.1_Silent_p.L348L|DEPDC5_uc011alu.1_Silent_p.L348L|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Silent_p.L348L|DEPDC5_uc003alr.1_Silent_p.L348L|DEPDC5_uc011alt.1_Silent_p.L320L	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	348					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						TGGACCGCCTACTCATGATCC	0.502													21	56					0	0	0	0	T	32198787	T	T	32198787	2	4	223	1	0	0	0	0	0	0	0	1	4464	378	14	5		5	DEPDC5	22	32198787	Silent	SNP	A	TCGA-CV-7101-01A-11D-2012-08	7558143	32198787	19105779	224	41118											
MEI1	150365	broad.mit.edu	37	chr22	42128529	42128529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtgcagagatgctggccGtgccctccaagaagcagtta	10	8	12	11	1	0	2	0	0	0	2	1	3	1	2	3	1	4	4	3	1	3	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr22:42128529G>A	uc003baz.1	+	11	1278	c.1253G>A	c.(1252-1254)CGT>CAT	p.R418H	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc003bay.3_Missense_Mutation_p.R418H|MEI1_uc011apd.1_RNA	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	418							binding			central_nervous_system(1)|skin(1)	2						GATGCTGGCCGTGCCCTCCAA	0.552													23	39					0	0	0	0	A	42128529	A	A	42128529	3	1	223	1	0	0	0	0	1	0	0	0	9518	1145	40	1	1295	1	MEI1	22	42128529	Missense_Mutation	SNP	G	TCGA-CV-7101-01A-11D-2012-08	9929742	42128529	9176037	225	41119											
PLXNB2	23654	broad.mit.edu	37	chr22	50727541	50727541	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagcgggtagggcaggtgctCcgagccacatgggaagctct	8	6	16	11	2	1	0	0	0	1	0	2	2	2	1	2	4	4	4	2	4	2	1			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chr22:50727541C>T	uc003bkv.3	-	4	1205	c.1099G>A	c.(1099-1101)GAG>AAG	p.E367K		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	367	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGCAGGTGCTCCGAGCCACAT	0.692													7	9					0	0	0	0	T	50727541	T	T	50727541	3	4	223	1	0	0	0	0	1	0	0	0	12179	864	30	2	4553	2	PLXNB2	22	50727541	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	8599012	50727541	577025	226	41120											
ARSF	416	broad.mit.edu	37	chrX	3021856	3021856	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgcgtcccaggaattgtcCgatggcctggaaaggtacca	9	8	12	12	3	0	0	0	0	0	0	3	3	3	2	5	4	1	1	5	4	3	2			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chrX:3021856C>T	uc004cre.1	+	9	1377	c.1156C>T	c.(1156-1158)CGA>TGA	p.R386*	ARSF_uc004crf.1_Nonsense_Mutation_p.R386*	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	386						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGGAATTGTCCGATGGCCTGG	0.458													12	11					0	0	0	0	T	3021856	T	T	3021856	4	4	223	1	0	0	0	0	0	1	0	0	993	644	23	1	1186	1	ARSF	23	3021856	Nonsense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08		3021856	152248704	227	41121											
MID1	4281	broad.mit.edu	37	chrX	10437743	10437743	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgagatactcactaacgaCgttggcttgtccggtgaata	11	11	10	9	3	1	2	1	2	0	1	2	4	2	2	1	2	2	2	1	2	4	5			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chrX:10437743C>T	uc004cte.3	-	7	1470	c.1279G>A	c.(1279-1281)GTC>ATC	p.V427I	MID1_uc004ctd.3_Missense_Mutation_p.V138I|MID1_uc004ctg.3_Missense_Mutation_p.V427I|MID1_uc004cth.3_Missense_Mutation_p.V389I|MID1_uc004ctk.3_Missense_Mutation_p.V427I|MID1_uc004cti.3_Missense_Mutation_p.V427I|MID1_uc004ctj.3_Missense_Mutation_p.V427I|MID1_uc011mie.1_RNA|MID1_uc004ctm.1_Missense_Mutation_p.V478I|MID1_uc004ctn.1_Missense_Mutation_p.V427I|MID1_uc004cto.1_Missense_Mutation_p.V389I|MID1_uc004csz.3_Missense_Mutation_p.V99I|MID1_uc004cta.3_Missense_Mutation_p.V183I|MID1_uc004ctb.3_Missense_Mutation_p.V87I|MID1_uc004ctc.3_Missense_Mutation_p.V194I|MID1_uc004ctl.1_Missense_Mutation_p.V183I	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	427	Fibronectin type-III.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						TCACTAACGACGTTGGCTTGT	0.443													21	37					0	0	0	0	T	10437743	T	T	10437743	3	4	223	1	0	0	0	0	1	0	0	0	9629	536	19	1	740	1	MID1	23	10437743	Missense_Mutation	SNP	C	TCGA-CV-7101-01A-11D-2012-08	7415887	10437743	144832817	228	41122											
MAGEA1	4100	broad.mit.edu	37	chrX	152483002	152483002	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgcagactcctctgctcAagagacatgatgactctcgt	10	10	9	12	1	3	4	1	2	2	2	5	5	4	4	1	0	2	2	1	0	1	0			TCGA-CV-7101-01A-11D-2012-08	TCGA-CV-7101-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	511c3fa8-476b-4ee8-8e93-1ab46bc40dbe	d4851311-cced-411f-bd9c-3179c2580e42	g.chrX:152483002A>T	uc004fhf.2	-	3	229	c.9T>A	c.(7-9)CTT>CTA	p.L3L		NM_004988	NP_004979	P43355	MAGA1_HUMAN	melanoma antigen family A, 1	3						cytoplasm|plasma membrane				central_nervous_system(7)|ovary(1)|lung(1)|breast(1)	10	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCTGCTCAAGAGACATGA	0.622													36	18					0	0	0	0	T	152483002	T	T	152483002	2	4	223	1	0	0	0	0	0	0	0	1	9214	117	5	5		5	MAGEA1	23	152483002	Silent	SNP	A	TCGA-CV-7101-01A-11D-2012-08	142045259	152483002	2787558	229	41123											
VPS13D	55187	broad.mit.edu	37	chr1	12443108	12443108	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacacttccatggagctttTggggccagttccacctgaac	8	11	10	12	0	0	2	0	2	0	0	2	3	2	3	4	3	2	2	4	3	1	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:12443108T>G	uc001atv.2	+	58	11405	c.11264T>G	c.(11263-11265)TTG>TGG	p.L3755W	VPS13D_uc001atw.2_Missense_Mutation_p.L3730W|VPS13D_uc001atx.2_Missense_Mutation_p.L2942W|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3754					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ATGGAGCTTTTGGGGCCAGTT	0.433													49	102					0	0	0	0	G	12443108	G	G	12443108	3	3	224	1	0	0	0	0	1	0	0	0	17260	1821	63	5	11490	5	VPS13D	1	12443108	Missense_Mutation	SNP	T	TCGA-CV-7102-01A-11D-2012-08		12443108	236807513	1	41124											
EIF4G3	8672	broad.mit.edu	37	chr1	21186878	21186878	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtggattccggcctcacCtggtcttctcttctctttgg	2	16	10	13	1	4	0	1	0	3	0	7	1	5	1	3	5	0	0	3	5	0	4	rs10916883		TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:21186878C>A	uc001bec.2	-	19	3332	c.3076G>T	c.(3076-3078)GGT>TGT	p.G1026C	EIF4G3_uc010odi.1_Missense_Mutation_p.G630C|EIF4G3_uc010odj.1_Missense_Mutation_p.G1025C|EIF4G3_uc009vpz.2_Missense_Mutation_p.G746C|EIF4G3_uc001bed.2_Missense_Mutation_p.G1026C|EIF4G3_uc001bef.2_Missense_Mutation_p.G1062C|EIF4G3_uc001bee.2_Missense_Mutation_p.G1032C	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1026					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CCGGCCTCACCTGGTCTTCTC	0.393													39	108					2.47872e-24	5.52277e-24	1	0	A	21186878	A	A	21186878	3	1	224	1	0	0	0	0	1	0	0	0	5062	695	24	4	1737	4	EIF4G3	1	21186878	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	8743770	21186878	228063743	2	41125											
KIAA0319L	79932	broad.mit.edu	37	chr1	35919263	35919264	+	Missense_Mutation	DNP	GC	CG	CG																															tcagctctttatctgggcctGcatctgcctgaggaggctta																										TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:35919263_35919264GC>CG	uc001byx.2	-	12	2065_2066	c.1807_1808GC>CG	c.(1807-1809)GCA>CGA	p.A603R	KIAA0319L_uc001byw.2_Missense_Mutation_p.A40R|KIAA0319L_uc010ohv.1_Missense_Mutation_p.A245R	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	603	PKD 4.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATCTGGGCCTGCATCTGCCTGA	0.475													8	39					0	0	0	0	CG	35919264	CG	CG	35919263	3	2	224	1	0	0	0	0	1	0	0	0	8208	1319	46	4	1381	4	KIAA0319L	1	35919263	Missense_Mutation	DNP	GC	TCGA-CV-7102-01A-11D-2012-08	14732385	35919263	213331358	3	41126											
SLC2A1	6513	broad.mit.edu	37	chr1	43396789	43396789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacagaaaagatggccactGagagggaccagagcgtggtg	14	4	15	8	1	0	4	0	1	0	4	0	6	0	5	2	3	2	0	2	3	3	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:43396789G>A	uc001cik.2	-	3	728	c.203C>T	c.(202-204)TCA>TTA	p.S68L		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	68	Helical; Name=2; (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	GATGGCCACTGAGAGGGACCA	0.592											OREG0013425	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	55					0	0	0	0	A	43396789	A	A	43396789	3	1	224	1	0	0	0	0	1	0	0	0	14602	1294	45	2	1307	2	SLC2A1	1	43396789	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	7477526	43396789	205853832	4	41127											
C8A	731	broad.mit.edu	37	chr1	57378266	57378266	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtgccgcctgggtagctTgggtgctgcctgtgagcaaa	6	9	15	11	1	0	1	0	1	0	0	0	1	0	1	4	2	5	4	4	2	2	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:57378266T>G	uc001cyo.2	+	10	1703	c.1571T>G	c.(1570-1572)TTG>TGG	p.L524W		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	524	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						CTGGGTAGCTTGGGTGCTGCC	0.592													11	82					0	0	0	0	G	57378266	G	G	57378266	3	3	224	1	0	0	0	0	1	0	0	0	2427	1821	63	5	1609	5	C8A	1	57378266	Missense_Mutation	SNP	T	TCGA-CV-7102-01A-11D-2012-08	13981477	57378266	191872355	5	41128											
SYDE2	84144	broad.mit.edu	37	chr1	85656306	85656307	+	Frame_Shift_Ins	INS	-	A	A																															aggcctcagagtactctgatINSatagccaattgcgtttcttt																										TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:85656306_85656307insA	uc009wcm.2	-	2	923_924	c.874_875insT	c.(874-876)TATfs	p.Y292fs	SYDE2_uc001dku.3_Frame_Shift_Ins_p.Y292fs	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	292					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		AGTACTCTGATATAGCCAATTG	0.381													---	---	---								A	85656307	A	A	85656306	7	5	224	1	0	1	1	0	0	0	0	0	15502	1406	49	0	2733	0	SYDE2	1	85656306	Frame_Shift_Ins	INS	-	TCGA-CV-7102-01A-11D-2012-08	28278040	85656306	163594315	6	41129											
GBP7	388646	broad.mit.edu	37	chr1	89616203	89616203	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcacttctgttttggaaaGaaatgcctgatccactccct	11	12	7	11	0	1	2	0	1	1	1	3	3	3	3	3	1	2	2	3	1	3	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:89616203G>T	uc001dna.2	-	6	820	c.681C>A	c.(679-681)TTC>TTA	p.F227L	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	227						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		GTTTTGGAAAGAAATGCCTGA	0.393													37	50					8.73648e-17	1.92405e-16	1	0	T	89616203	T	T	89616203	3	4	224	1	0	0	0	0	1	0	0	0	6314	933	33	2	1259	2	GBP7	1	89616203	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	3959897	89616203	159634418	7	41130											
CLK2	1196	broad.mit.edu	37	chr1	155234561	155234561	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcttcacactgcgctcatctCgcttctaggagcagaggaga	9	10	10	12	2	5	2	2	0	3	2	6	4	5	3	0	2	2	3	0	2	1	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:155234561C>T	uc001fjy.2	-	9	1228	c.938G>A	c.(937-939)CGA>CAA	p.R313Q	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjs.2_5'Flank|SCAMP3_uc001fju.2_5'Flank|SCAMP3_uc001fjv.2_5'Flank|SCAMP3_uc001fjt.2_5'Flank|CLK2_uc001fjw.2_Missense_Mutation_p.R312Q|CLK2_uc001fjx.2_Missense_Mutation_p.R85Q|CLK2_uc009wqm.2_Missense_Mutation_p.R313Q	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	313	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCGCTCATCTCGCTTCTAGGA	0.507								Other_conserved_DNA_damage_response_genes					27	31					0	0	0	0	T	155234561	T	T	155234561	3	4	224	1	0	0	0	0	1	0	0	0	3552	884	31	1	581	1	CLK2	1	155234561	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	65618358	155234561	94016060	8	41131											
ETV3L	440695	broad.mit.edu	37	chr1	157062482	157062482	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactgctttgaggttctccaGattgggggaagtaaggcttt	8	13	13	7	0	1	2	0	1	1	1	2	3	1	3	1	4	1	4	1	4	2	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:157062482G>C	uc001fqq.1	-	5	1330	c.1045C>G	c.(1045-1047)CTG>GTG	p.L349V		NM_001004341	NP_001004341	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	349						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Hepatocellular(266;0.158)	Prostate(1639;0.184)				AGGTTCTCCAGATTGGGGGAA	0.562													5	53					0	0	0	0	C	157062482	C	C	157062482	3	2	224	1	0	0	0	0	1	0	0	0	5304	933	33	2	44	2	ETV3L	1	157062482	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	1827921	157062482	92188139	9	41132											
MNDA	4332	broad.mit.edu	37	chr1	158817523	158817523	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatcttcttttgcagaaaagCgtacacaagaagaacacaat	18	9	6	8	1	2	3	0	0	2	3	2	3	2	3	0	0	4	2	0	0	8	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:158817523C>T	uc001fsz.1	+	6	1193	c.993C>T	c.(991-993)AGC>AGT	p.S331S		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	331	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TGCAGAAAAGCGTACACAAGA	0.368													9	40					0	0	0	0	T	158817523	T	T	158817523	2	4	224	1	0	0	0	0	0	0	0	1	9729	767	27	1		1	MNDA	1	158817523	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	1755041	158817523	90433098	10	41133											
ASPM	259266	broad.mit.edu	37	chr1	197115515	197115515	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccccgcgggcggcctcCgctcggtcgggctcacttcc	2	6	14	19	6	1	0	1	0	0	0	5	0	3	0	5	4	1	3	5	4	0	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:197115515C>T	uc001gtu.2	-	1	310	c.53G>A	c.(52-54)CGG>CAG	p.R18Q	ASPM_uc001gtv.2_Missense_Mutation_p.R18Q|ASPM_uc001gtw.3_5'UTR	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	18					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						gggcggcctccgctcggtcgg	0.154													10	44					0	0	0	0	T	197115515	T	T	197115515	3	4	224	1	0	0	0	0	1	0	0	0	1058	652	23	1	10492	1	ASPM	1	197115515	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	38297992	197115515	52135106	11	41134											
ELF3	1999	broad.mit.edu	37	chr1	201981088	201981088	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgcctggcccttgcagagaAggccagctggttgggggaac	7	7	16	11	0	0	1	0	0	0	1	0	3	0	2	3	5	4	3	3	5	2	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:201981088A>G	uc001gxg.3	+	2	3359	c.167A>G	c.(166-168)AAG>AGG	p.K56R	ELF3_uc001gxi.3_Missense_Mutation_p.K56R|ELF3_uc001gxh.3_Missense_Mutation_p.K56R	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	56	PNT.			EK -> GE (in Ref. 7; CAD29859).	epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						CTTGCAGAGAAGGCCAGCTGG	0.498													70	110					0	0	0	0	G	201981088	G	G	201981088	3	3	224	1	0	0	0	0	1	0	0	0	5079	72	3	5	173	5	ELF3	1	201981088	Missense_Mutation	SNP	A	TCGA-CV-7102-01A-11D-2012-08	4865573	201981088	47269533	12	41135											
PTPN7	5778	broad.mit.edu	37	chr1	202121757	202121757	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgcagcaggggcccagctGattctggtgtctgatggtct	5	10	16	10	1	3	2	0	2	3	0	3	2	3	2	1	5	2	3	1	5	0	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr1:202121757G>A	uc001gxm.1	-	8	919	c.788C>T	c.(787-789)TCA>TTA	p.S263L	PTPN7_uc001gxl.1_Missense_Mutation_p.S302L|PTPN7_uc001gxn.1_Missense_Mutation_p.S263L|PTPN7_uc010ppv.1_Missense_Mutation_p.S82L|PTPN7_uc010ppw.1_Missense_Mutation_p.S211L|PTPN7_uc010ppx.1_Missense_Mutation_p.S337L|PTPN7_uc010ppy.1_RNA|PTPN7_uc001gxo.1_Missense_Mutation_p.S215L	NM_002832	NP_002823	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type	263	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			skin(1)	1						GGGCCCAGCTGATTCTGGTGT	0.622													23	45					0	0	0	0	A	202121757	A	A	202121757	3	1	224	1	0	0	0	0	1	0	0	0	12858	1294	45	2	306	2	PTPN7	1	202121757	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	140669	202121757	47128864	13	41136											
C2orf16	84226	broad.mit.edu	37	chr2	27803074	27803074	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaagcttccaagagtcctaCttccacaatagatttgcagt	12	12	6	11	0	1	2	1	0	0	2	4	2	4	2	3	0	3	2	3	0	5	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:27803074C>T	uc002rkz.3	+	1	3686	c.3635C>T	c.(3634-3636)ACT>ATT	p.T1212I	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1212										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					AAGAGTCCTACTTCCACAATA	0.468													20	107					0	0	0	0	T	27803074	T	T	27803074	3	4	224	1	0	0	0	0	1	0	0	0	2167	565	20	4	3637	4	C2orf16	2	27803074	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08		27803074	215396299	14	41137											
LRPPRC	10128	broad.mit.edu	37	chr2	44209427	44209427	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtagaagcttctttggaatgCggccagttcttcgaacagaa	11	11	11	8	2	2	2	0	0	2	2	3	4	2	3	1	2	3	3	1	2	5	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:44209427C>T	uc002rtr.2	-	2	354	c.296G>A	c.(295-297)CGC>CAC	p.R99H	LRPPRC_uc010yob.1_Intron|LRPPRC_uc010faw.1_Missense_Mutation_p.R73H	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	99					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CTTTGGAATGCGGCCAGTTCT	0.338													9	44					0	0	0	0	T	44209427	T	T	44209427	3	4	224	1	0	0	0	0	1	0	0	0	9015	768	27	1	4036	1	LRPPRC	2	44209427	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	16406353	44209427	198989946	15	41138											
XPO1	7514	broad.mit.edu	37	chr2	61711150	61711150	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagtttaaactgtgtaggtgGaatagcaaggaatgctggga	14	10	14	3	0	0	0	0	0	0	0	0	3	0	3	0	4	3	4	0	4	8	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:61711150G>A	uc002sbj.2	-	21	3327	c.2599C>T	c.(2599-2601)CCA>TCA	p.P867S	XPO1_uc010fcl.2_Missense_Mutation_p.P863S|XPO1_uc010ypn.1_Missense_Mutation_p.P863S|XPO1_uc002sbk.2_Missense_Mutation_p.P428S|XPO1_uc002sbg.2_Missense_Mutation_p.P64S|XPO1_uc002sbh.2_Missense_Mutation_p.P514S	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	867					intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			TGTGTAGGTGGAATAGCAAGG	0.348													13	71					0	0	0	0	A	61711150	A	A	61711150	3	1	224	1	0	0	0	0	1	0	0	0	17513	1174	41	2	636	2	XPO1	2	61711150	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	17501723	61711150	181488223	16	41139											
ITPRIPL1	150771	broad.mit.edu	37	chr2	96993068	96993068	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaccctccatgagacccaGaaatttgatatcctggtgcc	11	9	9	12	0	0	3	0	2	0	2	2	5	2	4	5	2	2	0	5	2	3	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:96993068G>C	uc002svx.2	+	3	1034	c.699G>C	c.(697-699)CAG>CAC	p.Q233H	ITPRIPL1_uc010yuk.1_Missense_Mutation_p.Q225H|ITPRIPL1_uc002svy.2_Missense_Mutation_p.Q241H|ITPRIPL1_uc010yul.1_Missense_Mutation_p.Q225H	NM_001008949	NP_001008949	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-triphosphate receptor interacting	233	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(2)|ovary(1)	3						ATGAGACCCAGAAATTTGATA	0.612													18	48					0	0	0	0	C	96993068	C	C	96993068	3	2	224	1	0	0	0	0	1	0	0	0	7963	933	33	2	739	2	ITPRIPL1	2	96993068	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	35281918	96993068	146206305	17	41140											
FOXD4L1	200350	broad.mit.edu	37	chr2	114257054	114257054	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgcttccccgagagcacaTcgagggcggcggcccgagcg	6	4	16	15	7	0	1	0	0	0	1	2	4	1	1	3	3	3	2	3	3	0	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:114257054T>A	uc002tjw.3	+	1	394	c.221T>A	c.(220-222)ATC>AAC	p.I74N		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	74					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CGAGAGCACATCGAGGGCGGC	0.647													19	41					0	0	0	0	A	114257054	A	A	114257054	3	1	224	1	0	0	0	0	1	0	0	0	6032	1435	50	5	223	5	FOXD4L1	2	114257054	Missense_Mutation	SNP	T	TCGA-CV-7102-01A-11D-2012-08	17263986	114257054	128942319	18	41141											
TFCP2L1	29842	broad.mit.edu	37	chr2	122038715	122038715	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccttggttgaggtaggtcagCgtctcttcatgcagcttcac	6	13	11	11	1	4	1	3	1	1	0	5	1	4	1	1	3	3	4	1	3	1	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:122038715C>T	uc002tmx.2	-	2	288	c.195G>A	c.(193-195)ACG>ACA	p.T65T	TFCP2L1_uc010flr.2_Silent_p.T65T	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	65					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					GGTAGGTCAGCGTCTCTTCAT	0.627													12	69					0	0	0	0	T	122038715	T	T	122038715	2	4	224	1	0	0	0	0	0	0	0	1	15862	755	27	1		1	TFCP2L1	2	122038715	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	7781661	122038715	121160658	19	41142											
TANC1	85461	broad.mit.edu	37	chr2	160085398	160085399	+	Frame_Shift_Ins	INS	-	A	A																															gccagagcaagagcgaagagINSaaatagcaggtaccgtctgt																										TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:160085398_160085399insA	uc002uag.2	+	26	4416_4417	c.4142_4143insA	c.(4141-4143)AGAfs	p.R1381fs	TANC1_uc010zcm.1_Frame_Shift_Ins_p.R1373fs|TANC1_uc010fon.2_Frame_Shift_Ins_p.R225fs	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1381	TPR 3.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						AGAGCGAAGAGAAATAGCAGGT	0.47													---	---	---								A	160085399	A	A	160085398	7	5	224	1	0	1	1	0	0	0	0	0	15610	942	33	0	4236	0	TANC1	2	160085398	Frame_Shift_Ins	INS	-	TCGA-CV-7102-01A-11D-2012-08	38046683	160085398	83113975	20	41143											
DPP4	1803	broad.mit.edu	37	chr2	162902113	162902113	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ataatcattgatagaatgtcCaaactcatcctgtcaaacaa	17	11	4	9	0	3	2	3	1	0	1	5	2	5	2	2	0	2	0	2	0	6	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:162902113C>G	uc002ubz.2	-	5	856	c.295G>C	c.(295-297)GGA>CGA	p.G99R	DPP4_uc010fpb.2_5'UTR|DPP4_uc002uca.1_RNA|DPP4_uc002ucb.1_RNA	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	99	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	ATAGAATGTCCAAACTCATCC	0.343													12	46					0	0	0	0	G	162902113	G	G	162902113	3	3	224	1	0	0	0	0	1	0	0	0	4751	603	21	4	2093	4	DPP4	2	162902113	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	2816715	162902113	80297260	21	41144											
TTN	7273	broad.mit.edu	37	chr2	179424503	179424503	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctggcttactccacaagaCattgggtactggtcttcctc	7	13	9	12	0	2	1	0	0	2	1	5	1	4	1	2	3	2	2	2	3	3	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:179424503C>G	uc010zfg.1	-	275	78876	c.78652G>C	c.(78652-78654)GTC>CTC	p.V26218L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V19913L|TTN_uc010zfi.1_Missense_Mutation_p.V19846L|TTN_uc010zfj.1_Missense_Mutation_p.V19721L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27145							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCACAAGACATTGGGTACT	0.438													38	93					0	0	0	0	G	179424503	G	G	179424503	3	3	224	1	0	0	0	0	1	0	0	0	16803	478	17	4	21771	4	TTN	2	179424503	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	16522390	179424503	63774870	22	41145											
TTN	7273	broad.mit.edu	37	chr2	179456614	179456614	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caggtccttgggtggccctgGgggatcttttcaaagaagaa	9	10	14	8	0	2	2	1	0	1	2	3	3	3	3	2	5	0	0	2	5	3	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:179456614G>C	uc010zfg.1	-	252	52452	c.52228C>G	c.(52228-52230)CCA>GCA	p.P17410A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P11105A|TTN_uc010zfi.1_Missense_Mutation_p.P11038A|TTN_uc010zfj.1_Missense_Mutation_p.P10913A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18337							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGGCCCTGGGGGATCTTTT	0.428													3	65					0	0	0	0	C	179456614	C	C	179456614	3	2	224	1	0	0	0	0	1	0	0	0	16803	1232	43	4	48287	4	TTN	2	179456614	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	32111	179456614	63742759	23	41146											
DES	1674	broad.mit.edu	37	chr2	220286275	220286275	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggaagctgctggagggagagGagagccggtgaggggccagg	9	3	23	6	1	0	3	0	1	0	2	0	7	0	5	2	8	3	2	2	8	1	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr2:220286275G>T	uc002vll.2	+	6	1323	c.1237G>T	c.(1237-1239)GAG>TAG	p.E413*		NM_001927	NP_001918	P17661	DESM_HUMAN	desmin	413	Tail.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			central_nervous_system(2)	2		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		GGAGGGAGAGGAGAGCCGGTG	0.622													14	44					7.93312e-07	1.5908e-06	1	0	T	220286275	T	T	220286275	4	4	224	1	0	0	0	0	0	1	0	0	4471	1175	41	2	1259	2	DES	2	220286275	Nonsense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	40829661	220286275	22913098	24	41147											
ABHD5	51099	broad.mit.edu	37	chr3	43753250	43753250	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggtttccctgaacgaccaGaccttgctgatcaagacaga	11	8	11	11	1	1	5	1	2	0	3	2	6	2	5	3	2	2	2	3	2	2	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:43753250G>C	uc003cmx.2	+	4	666	c.556G>C	c.(556-558)GAC>CAC	p.D186H		NM_016006	NP_057090	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	186					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			ovary(1)	1		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		TGAACGACCAGACCTTGCTGA	0.453													11	54					0	0	0	0	C	43753250	C	C	43753250	3	2	224	1	0	0	0	0	1	0	0	0	85	942	33	2	570	2	ABHD5	3	43753250	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		43753250	154269180	25	41148											
RHOA	387	broad.mit.edu	37	chr3	49412905	49412905	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatctgccacatagttctCaaacactgtgggcacataca	13	10	7	11	0	2	0	1	0	2	0	3	1	2	0	1	1	3	2	1	1	4	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:49412905C>G	uc003cwu.2	-	2	394	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	40	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATAGTTCTCAAACACTGTG	0.438													24	103					0	0	0	0	G	49412905	G	G	49412905	3	3	224	1	0	0	0	0	1	0	0	0	13396	835	29	2	479	2	RHOA	3	49412905	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	5659655	49412905	148609525	26	41149											
PLCXD2	257068	broad.mit.edu	37	chr3	111426919	111426919	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagaacctgacatttcgaGaacagctggaagctgggatc	12	8	11	10	1	1	3	1	1	0	2	3	6	1	5	1	2	4	2	1	2	3	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:111426919G>C	uc003dya.2	+	2	896	c.310G>C	c.(310-312)GAA>CAA	p.E104Q	PLCXD2_uc003dyb.2_Missense_Mutation_p.E104Q|PLCXD2_uc003dxz.2_Missense_Mutation_p.E104Q	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	104	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						GACATTTCGAGAACAGCTGGA	0.522													11	83					0	0	0	0	C	111426919	C	C	111426919	3	2	224	1	0	0	0	0	1	0	0	0	12097	943	33	2	316	2	PLCXD2	3	111426919	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	62014014	111426919	86595511	27	41150											
KALRN	8997	broad.mit.edu	37	chr3	124165030	124165030	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctgagtgagctcctgcaGagggagaatcgcgtgctgca	9	8	14	10	2	0	4	0	2	0	2	3	5	2	4	2	1	4	4	2	1	1	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:124165030G>T	uc003ehg.2	+	20	3457	c.3330G>T	c.(3328-3330)CAG>CAT	p.Q1110H	KALRN_uc010hrv.1_Missense_Mutation_p.Q1101H|KALRN_uc003ehf.1_Missense_Mutation_p.Q1110H|KALRN_uc011bjy.1_Missense_Mutation_p.Q1101H|KALRN_uc003ehh.1_Missense_Mutation_p.Q456H	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1110					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AGCTCCTGCAGAGGGAGAATC	0.577													12	60					2.27111e-07	4.60262e-07	1	0	T	124165030	T	T	124165030	3	4	224	1	0	0	0	0	1	0	0	0	8014	933	33	2	3408	2	KALRN	3	124165030	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	12738111	124165030	73857400	28	41151											
ABTB1	80325	broad.mit.edu	37	chr3	127395886	127395886	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgccagctgtgggacctgctCagcgacctggaggccaagtg	7	7	15	12	1	1	0	1	0	0	0	1	3	1	2	4	3	4	2	4	3	1	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:127395886C>T	uc003ejt.2	+	7	691	c.603C>T	c.(601-603)CTC>CTT	p.L201L	ABTB1_uc003ejr.2_Silent_p.L59L|ABTB1_uc003ejs.2_Silent_p.L176L|ABTB1_uc003eju.2_Silent_p.L59L|ABTB1_uc010hsm.2_5'UTR	NM_172027	NP_742024	Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	201						cytoplasm|nucleolus|plasma membrane	translation elongation factor activity				0						GGGACCTGCTCAGCGACCTGG	0.667													12	43					0	0	0	0	T	127395886	T	T	127395886	2	4	224	1	0	0	0	0	0	0	0	1	102	813	29	2		2	ABTB1	3	127395886	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	3230856	127395886	70626544	29	41152											
ARMC8	25852	broad.mit.edu	37	chr3	138003316	138003316	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcggatgggacaacagcaaAagatcttattatgaccaatg	16	8	10	7	1	1	2	0	1	1	1	1	4	1	4	1	2	3	1	1	2	6	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:138003316A>G	uc003esa.1	+	20	2094	c.1727A>G	c.(1726-1728)AAA>AGA	p.K576R	TXNDC6_uc003esd.1_Intron|TXNDC6_uc010huf.1_Intron|TXNDC6_uc003ese.1_Intron|ARMC8_uc011bmf.1_Missense_Mutation_p.K559R|ARMC8_uc011bmg.1_Missense_Mutation_p.K523R|ARMC8_uc011bmh.1_Missense_Mutation_p.K517R|ARMC8_uc003esb.1_Missense_Mutation_p.K548R|ARMC8_uc003esc.1_Missense_Mutation_p.K348R|ARMC8_uc003esf.1_Missense_Mutation_p.K159R	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	590	ARM 13.						binding				0						ACAACAGCAAAAGATCTTATT	0.443													77	156					0	0	0	0	G	138003316	G	G	138003316	3	3	224	1	0	0	0	0	1	0	0	0	959	14	1	5	1867	5	ARMC8	3	138003316	Missense_Mutation	SNP	A	TCGA-CV-7102-01A-11D-2012-08	10607430	138003316	60019114	30	41153											
RBP2	5948	broad.mit.edu	37	chr3	139173605	139173605	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccctcaatccactgcttcCagccgcggttctccttctcc	4	11	5	21	2	3	0	1	0	2	0	7	0	5	0	7	1	2	2	7	1	1	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:139173605C>T	uc003eth.2	-	3	371	c.320G>A	c.(319-321)TGG>TAG	p.W107*		NM_004164	NP_004155	P50120	RET2_HUMAN	retinol binding protein 2, cellular	107					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			skin(1)	1					Vitamin A(DB00162)	CCACTGCTTCCAGCCGCGGTT	0.532													31	160					0	0	0	0	T	139173605	T	T	139173605	4	4	224	1	0	0	0	0	0	1	0	0	13221	595	21	4	92	4	RBP2	3	139173605	Nonsense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	1170289	139173605	58848825	31	41154											
GFM1	85476	broad.mit.edu	37	chr3	158363454	158363454	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccgatggtcttcatcagggGtgattcctaatgaaaaaata	13	11	10	7	1	3	2	2	2	1	0	4	3	4	2	2	3	0	0	2	3	5	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:158363454G>A	uc003fce.2	+	2	225	c.118G>A	c.(118-120)GTG>ATG	p.V40M	GFM1_uc003fcd.2_Missense_Mutation_p.V40M|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_5'Flank	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	40					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TTCATCAGGGGTGATTCCTAA	0.373													10	49					0	0	0	0	A	158363454	A	A	158363454	3	1	224	1	0	0	0	0	1	0	0	0	6378	1261	44	4	124	4	GFM1	3	158363454	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	19189849	158363454	39658976	32	41155											
HTR3E	285242	broad.mit.edu	37	chr3	183824397	183824397	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggttgcagttcagccaCgcgatggacgccatgctctt	6	11	12	12	3	2	0	1	0	1	0	2	2	2	1	2	2	3	4	2	2	0	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:183824397C>T	uc010hxq.2	+	9	1753	c.1287C>T	c.(1285-1287)CAC>CAT	p.H429H	HTR3E_uc003fml.3_Silent_p.H414H|HTR3E_uc003fmm.2_Silent_p.H444H|HTR3E_uc010hxr.2_Silent_p.H455H|HTR3E_uc003fmn.2_Silent_p.H429H	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	429	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGTTCAGCCACGCGATGGACG	0.607													22	97					0	0	0	0	T	183824397	T	T	183824397	2	4	224	1	0	0	0	0	0	0	0	1	7487	535	19	1		1	HTR3E	3	183824397	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	25460943	183824397	14198033	33	41156											
KIAA0226	9711	broad.mit.edu	37	chr3	197427812	197427812	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatcacctggggaatcattCtggctgctgacccaggatgc	8	9	12	12	0	3	1	2	1	1	0	3	3	3	3	2	4	2	3	2	4	1	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr3:197427812C>G	uc003fyc.2	-	7	1116	c.933G>C	c.(931-933)CAG>CAC	p.Q311H	KIAA0226_uc003fyd.3_Missense_Mutation_p.Q251H|KIAA0226_uc003fye.1_Missense_Mutation_p.Q18H|KIAA0226_uc003fyf.2_Missense_Mutation_p.Q144H|KIAA0226_uc003fyg.2_Missense_Mutation_p.Q304H	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	311	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		GGGAATCATTCTGGCTGCTGA	0.577													9	61					0	0	0	0	G	197427812	G	G	197427812	3	3	224	1	0	0	0	0	1	0	0	0	8201	912	32	2	2090	2	KIAA0226	3	197427812	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	13603415	197427812	594618	34	41157											
ADD1	118	broad.mit.edu	37	chr4	2877732	2877732	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacttcgaccgagtagatgaGaacaacccagagtacttgag	14	8	10	9	2	0	4	0	2	0	3	1	7	0	4	2	0	4	2	2	0	5	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:2877732G>C	uc003gfr.2	+	2	278	c.90G>C	c.(88-90)GAG>GAC	p.E30D	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Missense_Mutation_p.E30D|ADD1_uc003gfo.2_Missense_Mutation_p.E30D|ADD1_uc003gfp.2_Missense_Mutation_p.E30D|ADD1_uc003gfq.2_Missense_Mutation_p.E30D|ADD1_uc003gfs.2_Missense_Mutation_p.E30D|ADD1_uc003gft.3_Missense_Mutation_p.E30D	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	30					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GAGTAGATGAGAACAACCCAG	0.517													27	98					0	0	0	0	C	2877732	C	C	2877732	3	2	224	1	0	0	0	0	1	0	0	0	304	933	33	2	92	2	ADD1	4	2877732	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		2877732	188276544	35	41158											
ABLIM2	84448	broad.mit.edu	37	chr4	8021358	8021358	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgtaccatgctgtctgtaGatagggggtttcctatagat	9	13	11	8	1	1	2	0	0	1	2	2	2	2	2	3	2	2	4	3	2	5	6			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:8021358G>C	uc003gko.2	-	13	1454	c.1311C>G	c.(1309-1311)ATC>ATG	p.I437M	ABLIM2_uc003gkk.2_Missense_Mutation_p.I100M|ABLIM2_uc003gkl.2_Missense_Mutation_p.I164M|ABLIM2_uc003gkj.3_Missense_Mutation_p.I470M|ABLIM2_uc003gkm.3_Intron|ABLIM2_uc003gkp.2_Intron|ABLIM2_uc003gkq.2_Missense_Mutation_p.I437M|ABLIM2_uc003gkr.2_Intron|ABLIM2_uc003gks.3_Intron	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	437					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3						GCTGTCTGTAGATAGGGGGTT	0.473													13	55					0	0	0	0	C	8021358	C	C	8021358	3	2	224	1	0	0	0	0	1	0	0	0	95	932	33	2	576	2	ABLIM2	4	8021358	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	5143626	8021358	183132918	36	41159											
SLIT2	9353	broad.mit.edu	37	chr4	20541203	20541203	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atactctccattctttatctActctgtaagtatgaaaaata	14	16	3	8	0	4	1	0	1	4	0	5	1	4	1	1	0	2	2	1	0	8	8			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:20541203A>G	uc003gpr.1	+	19	2176	c.1972A>G	c.(1972-1974)ACT>GCT	p.T658A	SLIT2_uc003gps.1_Missense_Mutation_p.T650A	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	658					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TTCTTTATCTACTCTGTAAGT	0.289													9	33					0	0	0	0	G	20541203	G	G	20541203	3	3	224	1	0	0	0	0	1	0	0	0	14804	391	14	5	2046	5	SLIT2	4	20541203	Missense_Mutation	SNP	A	TCGA-CV-7102-01A-11D-2012-08	12519845	20541203	170613073	37	41160											
KCTD8	386617	broad.mit.edu	37	chr4	44177085	44177085	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttaaagtgttaggttggtGagctgttgcctgctgggcac	6	14	15	6	0	0	1	0	1	0	0	0	1	0	1	1	3	3	7	1	3	3	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:44177085G>A	uc003gwu.2	-	2	1428	c.1144C>T	c.(1144-1146)CAC>TAC	p.H382Y		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	382						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TTAGGTTGGTGAGCTGTTGCC	0.507										HNSCC(17;0.042)			22	140					0	0	0	0	A	44177085	A	A	44177085	3	1	224	1	0	0	0	0	1	0	0	0	8154	1290	45	2	281	2	KCTD8	4	44177085	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	23635882	44177085	146977191	38	41161											
UGT2A1	10941	broad.mit.edu	37	chr4	70513058	70513058	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatagaatctccaaatggttGaaggagatggtctattttcc	12	13	10	6	0	2	3	0	1	2	2	4	5	3	3	2	3	0	1	2	3	5	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:70513058G>A	uc003hem.3	-	1	368	c.305C>T	c.(304-306)TCA>TTA	p.S102L	UGT2A1_uc011caq.1_Missense_Mutation_p.S102L|UGT2A1_uc010ihu.2_Missense_Mutation_p.S102L|UGT2A1_uc010iht.2_Missense_Mutation_p.S102L	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	102	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						CCAAATGGTTGAAGGAGATGG	0.413													11	60					0	0	0	0	A	70513058	A	A	70513058	3	1	224	1	0	0	0	0	1	0	0	0	17021	1294	45	2	1302	2	UGT2A1	4	70513058	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	26335973	70513058	120641218	39	41162											
MMRN1	22915	broad.mit.edu	37	chr4	90857719	90857719	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaacttcttcagaaaggtcTaacagaatttgtggaaccaa	15	11	7	8	0	4	2	2	0	2	2	4	3	4	3	1	2	3	0	1	2	6	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:90857719T>C	uc003hst.2	+	6	2959	c.2888T>C	c.(2887-2889)CTA>CCA	p.L963P	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.L705P	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	963					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CAGAAAGGTCTAACAGAATTT	0.378													18	37					0	0	0	0	C	90857719	C	C	90857719	3	2	224	1	0	0	0	0	1	0	0	0	9723	1522	53	5	2910	5	MMRN1	4	90857719	Missense_Mutation	SNP	T	TCGA-CV-7102-01A-11D-2012-08	20344661	90857719	100296557	40	41163											
ALPK1	80216	broad.mit.edu	37	chr4	113353568	113353568	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcctatctgaattccagtggGagttcttgggtttcattgcc	6	16	10	9	0	3	1	1	1	2	0	5	2	5	2	3	2	1	2	3	2	2	6			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:113353568G>C	uc003iap.3	+	11	3144	c.2865G>C	c.(2863-2865)GGG>GGC	p.G955G	ALPK1_uc003ian.3_Silent_p.G955G|ALPK1_uc011cfx.1_Silent_p.G877G|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Silent_p.G783G	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	955	Ser-rich.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		ATTCCAGTGGGAGTTCTTGGG	0.512													13	68					0	0	0	0	C	113353568	C	C	113353568	2	2	224	1	0	0	0	0	0	0	0	1	544	1161	41	2		2	ALPK1	4	113353568	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08	22495849	113353568	77800708	41	41164											
QRFPR	84109	broad.mit.edu	37	chr4	122257976	122257976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctacctcaagttgttgcaCgtgccacatgggtgatccta	8	12	10	11	1	2	1	1	1	1	0	3	1	3	1	3	1	3	3	3	1	3	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:122257976C>T	uc010inj.1	-	3	926	c.547G>A	c.(547-549)GTG>ATG	p.V183M	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_Missense_Mutation_p.V183M	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	183	Helical; Name=4; (Potential).					plasma membrane	neuropeptide Y receptor activity				0						AGTTGTTGCACGTGCCACATG	0.423													97	223					0	0	0	0	T	122257976	T	T	122257976	3	4	224	1	0	0	0	0	1	0	0	0	12943	536	19	1	764	1	QRFPR	4	122257976	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	8904408	122257976	68896300	42	41165											
HSPA4L	22824	broad.mit.edu	37	chr4	128753927	128753927	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaagctaatagtgaacaCaatggcccaatggatggaca	17	6	9	9	0	0	1	0	1	0	0	0	3	0	3	2	3	2	1	2	3	7	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:128753927C>G	uc003ifm.2	+	19	2671	c.2418C>G	c.(2416-2418)CAC>CAG	p.H806Q	HSPA4L_uc011cgr.1_Missense_Mutation_p.H773Q	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	806				H -> R (in Ref. 1; BAA75063).	protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						ATAGTGAACACAATGGCCCAA	0.408													12	61					0	0	0	0	G	128753927	G	G	128753927	3	3	224	1	0	0	0	0	1	0	0	0	7452	477	17	4	2492	4	HSPA4L	4	128753927	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	6495951	128753927	62400349	43	41166											
LRBA	987	broad.mit.edu	37	chr4	151388836	151388836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaattaccttggacaaatCtctgaagttggtgggcaagg	13	10	12	6	0	1	2	0	1	1	1	2	3	1	3	1	4	1	2	1	4	5	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:151388836C>T	uc010ipj.2	-	45	7276	c.6802G>A	c.(6802-6804)GAT>AAT	p.D2268N	LRBA_uc010ipi.2_5'UTR|LRBA_uc003ils.3_Missense_Mutation_p.D158N|LRBA_uc003ilt.3_Missense_Mutation_p.D916N|LRBA_uc003ilu.3_Missense_Mutation_p.D2257N	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2268	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TTGGACAAATCTCTGAAGTTG	0.313													8	54					0	0	0	0	T	151388836	T	T	151388836	3	4	224	1	0	0	0	0	1	0	0	0	8981	913	32	2	1845	2	LRBA	4	151388836	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	22634909	151388836	39765440	44	41167											
PALLD	23022	broad.mit.edu	37	chr4	169611844	169611844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctgcaggtccagtggtttCggcaagggagtgaaatccaa	10	9	13	9	1	1	1	0	1	1	0	4	2	3	2	2	4	1	3	2	4	3	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:169611844C>T	uc011cjx.1	+	7	1637	c.1426C>T	c.(1426-1428)CGG>TGG	p.R476W	PALLD_uc003iru.2_Missense_Mutation_p.R476W|PALLD_uc003irv.2_Missense_Mutation_p.R94W	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	476	Ig-like C2-type 2.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CCAGTGGTTTCGGCAAGGGAG	0.527									Pancreatic_Cancer_Familial_Clustering_of				28	131					0	0	0	0	T	169611844	T	T	169611844	3	4	224	1	0	0	0	0	1	0	0	0	11461	875	31	1	1448	1	PALLD	4	169611844	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	18223008	169611844	21542432	45	41168											
ADAM29	11086	broad.mit.edu	37	chr4	175897744	175897744	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcacaacctagatgcataatGcatgaaggcaacccaccaat	16	7	6	12	0	1	2	1	1	0	1	1	2	1	2	3	1	4	3	3	1	6	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:175897744G>A	uc003iuc.2	+	5	1738	c.1068G>A	c.(1066-1068)ATG>ATA	p.M356I	ADAM29_uc003iud.2_Missense_Mutation_p.M356I|ADAM29_uc010irr.2_Missense_Mutation_p.M356I|ADAM29_uc011cki.1_Missense_Mutation_p.M356I	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	356	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GATGCATAATGCATGAAGGCA	0.388													19	107					0	0	0	0	A	175897744	A	A	175897744	3	1	224	1	0	0	0	0	1	0	0	0	247	1319	46	4	1070	4	ADAM29	4	175897744	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	6285900	175897744	15256532	46	41169											
CCDC110	256309	broad.mit.edu	37	chr4	186382220	186382220	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccaaatccttttcaatgcGcgtgccaaacaccagatttt	12	12	5	12	2	1	1	1	0	0	1	2	1	2	1	4	0	4	0	4	0	4	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:186382220G>A	uc003ixu.3	-	5	407	c.331C>T	c.(331-333)CGC>TGC	p.R111C	CCDC110_uc003ixv.3_Intron|CCDC110_uc011ckt.1_Missense_Mutation_p.R111C	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	111						nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTTTCAATGCGCGTGCCAAAC	0.338													20	95					0	0	0	0	A	186382220	A	A	186382220	3	1	224	1	0	0	0	0	1	0	0	0	2759	1087	38	1	2182	1	CCDC110	4	186382220	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	10484476	186382220	4772056	47	41170											
SORBS2	8470	broad.mit.edu	37	chr4	186545017	186545017	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttggcatggatttggacttCtggatcagcttttcgaattc	7	17	10	7	1	2	0	1	0	1	0	4	4	2	3	0	4	1	2	0	4	1	6			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr4:186545017C>G	uc003iyl.2	-	13	2412	c.1554G>C	c.(1552-1554)CAG>CAC	p.Q518H	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.Q618H|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.Q422H|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.Q632H|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	518						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		ATTTGGACTTCTGGATCAGCT	0.562													16	79					0	0	0	0	G	186545017	G	G	186545017	3	3	224	1	0	0	0	0	1	0	0	0	14992	912	32	2	1784	2	SORBS2	4	186545017	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	162797	186545017	4609259	48	41171											
MTRR	4552	broad.mit.edu	37	chr5	7885832	7885832	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaatacagacttttcctatCagcctggagatgccttcagc	11	11	8	11	0	2	3	2	0	0	3	3	4	3	3	3	1	4	0	3	1	3	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:7885832C>T	uc003jed.2	+	7	1033	c.1003C>T	c.(1003-1005)CAG>TAG	p.Q335*	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Nonsense_Mutation_p.Q308*|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	335	FAD-binding FR-type.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CTTTTCCTATCAGCCTGGAGA	0.383													10	84					0	0	0	0	T	7885832	T	T	7885832	4	4	224	1	0	0	0	0	0	1	0	0	10014	827	29	2	1029	2	MTRR	5	7885832	Nonsense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08		7885832	173029428	49	41172											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139838838	139838838	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctgaagttgcagactttCttattaaggcaggggctgat	9	15	11	6	0	2	3	0	2	2	1	2	3	2	3	0	3	1	4	0	3	3	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:139838838C>G	uc003lfs.1	+	9	1694	c.1570C>G	c.(1570-1572)CTT>GTT	p.L524V	ANKHD1_uc003lfq.1_Missense_Mutation_p.L524V|ANKHD1_uc003lfr.2_Missense_Mutation_p.L524V|ANKHD1_uc003lft.1_5'UTR|ANKHD1_uc003lfu.1_5'UTR|ANKHD1_uc003lfp.2_Missense_Mutation_p.L513V|ANKHD1_uc003lfo.2_Missense_Mutation_p.L524V|ANKHD1_uc010jfk.2_Missense_Mutation_p.L524V	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	524						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGACTTTCTTATTAAGGC	0.443													15	60					0	0	0	0	G	139838838	G	G	139838838	3	3	224	1	0	0	0	0	1	0	0	0	629	913	32	2	1604	2	ANKHD1-EIF4EBP3	5	139838838	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	131953006	139838838	41076422	50	41173											
PCDHB11	56125	broad.mit.edu	37	chr5	140580954	140580954	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcgtgggcgccacagaccGcggctccccggctttgagca	5	5	14	17	6	0	2	0	1	0	1	1	2	1	2	5	3	1	3	5	3	0	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:140580954G>A	uc003liy.2	+	1	1607	c.1607G>A	c.(1606-1608)CGC>CAC	p.R536H	PCDHB11_uc011daj.1_Missense_Mutation_p.R171H	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	536	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCACAGACCGCGGCTCCCCG	0.667													48	88					0	0	0	0	A	140580954	A	A	140580954	3	1	224	1	0	0	0	0	1	0	0	0	11590	1087	38	1	1609	1	PCDHB11	5	140580954	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	742116	140580954	40334306	51	41174											
PCDHB12	56124	broad.mit.edu	37	chr5	140589638	140589638	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agatggtttgttctatcccgGaggacatcccattcgtgcta	8	13	10	10	2	1	1	0	0	1	1	4	3	3	3	2	3	1	3	2	3	2	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:140589638G>A	uc003liz.2	+	1	1348	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	PCDHB12_uc011dak.1_Missense_Mutation_p.E50K	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	387	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCTATCCCGGAGGACATCCC	0.468													12	45					0	0	0	0	A	140589638	A	A	140589638	3	1	224	1	0	0	0	0	1	0	0	0	11591	1175	41	2	1161	2	PCDHB12	5	140589638	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	8684	140589638	40325622	52	41175											
PCDHB12	56124	broad.mit.edu	37	chr5	140589962	140589962	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actcgctgctgccgtcccagGacccgcacctgcccctcgcc	4	6	9	22	4	0	0	0	0	0	0	3	1	1	1	7	1	3	3	7	1	0	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:140589962G>A	uc003liz.2	+	1	1672	c.1483G>A	c.(1483-1485)GAC>AAC	p.D495N	PCDHB12_uc011dak.1_Missense_Mutation_p.D158N	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	495	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCGTCCCAGGACCCGCACCT	0.662													22	159					0	0	0	0	A	140589962	A	A	140589962	3	1	224	1	0	0	0	0	1	0	0	0	11591	1174	41	2	1485	2	PCDHB12	5	140589962	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	324	140589962	40325298	53	41176											
EBF1	1879	broad.mit.edu	37	chr5	158524010	158524010	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctccacgaaccccacaaacGctgtcctctcgatctccacg	9	8	5	19	4	3	0	0	0	3	0	7	2	4	0	5	0	2	1	5	0	2	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:158524010G>T	uc010jip.2	-	2	565	c.263C>A	c.(262-264)GCG>GAG	p.A88E	EBF1_uc011ddw.1_5'Flank|EBF1_uc011ddx.1_Missense_Mutation_p.A88E|EBF1_uc003lxl.3_Missense_Mutation_p.A88E	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	88					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCCACAAACGCTGTCCTCTC	0.637			T	HMGA2	lipoma								12	23					1.61879e-10	3.35195e-10	1	0	T	158524010	T	T	158524010	3	4	224	1	0	0	0	0	1	0	0	0	4902	1087	38	3	1572	3	EBF1	5	158524010	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	17934048	158524010	22391250	54	41177											
GABRB2	2561	broad.mit.edu	37	chr5	160973365	160973365	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agacgaatgtcatagcctttCaggagtctatccaccgtctc	10	11	8	12	2	4	1	2	0	2	1	6	3	5	2	3	1	1	0	3	1	3	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:160973365C>G	uc003lys.1	-	3	350	c.132G>C	c.(130-132)CTG>CTC	p.L44L	GABRB2_uc011deh.1_Intron|GABRB2_uc003lyr.1_Silent_p.L44L|GABRB2_uc003lyt.1_Silent_p.L44L|GABRB2_uc010jiu.1_Intron|GABRB2_uc011dei.1_Silent_p.L44L	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	44	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CATAGCCTTTCAGGAGTCTAT	0.453													6	35					0	0	0	0	G	160973365	G	G	160973365	2	3	224	1	0	0	0	0	0	0	0	1	6201	813	29	2		2	GABRB2	5	160973365	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	2449355	160973365	19941895	55	41178											
GABRG2	2566	broad.mit.edu	37	chr5	161531032	161531032	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtagtgaagacaacttccGgtaagatgcactggcaaaga	16	7	11	7	1	0	4	0	1	0	3	1	4	1	4	1	2	2	4	1	2	6	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:161531032G>T	uc003lyz.3	+	6	1127	c.769G>T	c.(769-771)GGA>TGA	p.G257*	GABRG2_uc010jjc.2_Nonsense_Mutation_p.G297*|GABRG2_uc003lyy.3_Nonsense_Mutation_p.G257*|GABRG2_uc011dej.1_Nonsense_Mutation_p.G162*	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	257	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GACAACTTCCGGTAAGATGCA	0.383													16	34					2.5808e-16	5.65106e-16	1	0	T	161531032	T	T	161531032	4	4	224	1	0	0	0	0	0	1	0	0	6206	1130	39	3	915	3	GABRG2	5	161531032	Nonsense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	557667	161531032	19384228	56	41179											
DDX41	51428	broad.mit.edu	37	chr5	176943153	176943153	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacactctccaggatcttctCttcttccttcagctgcttct	6	16	4	15	0	6	0	1	0	5	0	9	1	7	1	2	1	3	2	2	1	1	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:176943153C>A	uc003mho.2	-	4	361	c.340G>T	c.(340-342)GAG>TAG	p.E114*	DDX41_uc003mhm.2_5'Flank|DDX41_uc003mhn.2_5'UTR|DDX41_uc003mhp.2_5'UTR|DDX41_uc003mhq.1_5'UTR	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	114					apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			AGGATCTTCTCTTCTTCCTTC	0.522													39	205					6.45866e-13	1.35953e-12	1	0	A	176943153	A	A	176943153	4	1	224	1	0	0	0	0	0	1	0	0	4378	922	32	2	1584	2	DDX41	5	176943153	Nonsense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	15412121	176943153	3972107	57	41180											
ZFP2	80108	broad.mit.edu	37	chr5	178358852	178358852	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttactgtccatcaacgaactCacaccggagagaaaccctat	14	8	6	13	2	2	1	2	0	0	1	3	4	3	2	3	1	4	0	3	1	5	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr5:178358852C>A	uc003mjn.1	+	5	1047	c.538C>A	c.(538-540)CAC>AAC	p.H180N	ZFP2_uc010jky.2_Missense_Mutation_p.H180N|ZFP2_uc010jkx.1_Missense_Mutation_p.H180N	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	180	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		TCAACGAACTCACACCGGAGA	0.398													8	37					1.12685e-05	2.23609e-05	1	0	A	178358852	A	A	178358852	3	1	224	1	0	0	0	0	1	0	0	0	17708	826	29	2	540	2	ZFP2	5	178358852	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	1415699	178358852	2556408	58	41181											
EHMT2	10919	broad.mit.edu	37	chr6	31860266	31860266	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccaccaccgtctcccacTcctccagggacccggggtcc	6	5	8	22	2	1	0	0	0	1	0	5	1	4	1	8	3	0	0	8	3	0	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:31860266T>C	uc003nxz.1	-	7	792	c.782A>G	c.(781-783)GAG>GGG	p.E261G	EHMT2_uc003nxy.1_Missense_Mutation_p.E52G|EHMT2_uc011don.1_Missense_Mutation_p.E318G|EHMT2_uc003nya.1_Missense_Mutation_p.E261G	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	261					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CGTCTCCCACTCCTCCAGGGA	0.547													15	61					0	0	0	0	C	31860266	C	C	31860266	3	2	224	1	0	0	0	0	1	0	0	0	5006	1551	54	5	2938	5	EHMT2	6	31860266	Missense_Mutation	SNP	T	TCGA-CV-7102-01A-11D-2012-08		31860266	139254801	59	41182											
PSMB8	5696	broad.mit.edu	37	chr6	32808747	32808747	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccaccattattgattggCttcccggtactggtgcagca	8	11	9	13	1	0	1	0	1	0	0	1	1	1	1	4	3	3	4	4	3	2	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:32808747C>A	uc003oce.2	-	6	863	c.820G>T	c.(820-822)GCC>TCC	p.A274S	TAP2_uc011dqf.1_5'Flank|TAP2_uc003ocb.1_5'Flank|TAP2_uc003occ.2_5'Flank|TAP2_uc003ocd.2_5'Flank|PSMB8_uc003ocf.2_Missense_Mutation_p.A270S	NM_148919	NP_683720	P28062	PSB8_HUMAN	proteasome beta 8 subunit isoform E2 proprotein	274					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			skin(1)	1						TATTGATTGGCTTCCCGGTAC	0.512													16	46					2.23348e-06	4.45527e-06	1	0	A	32808747	A	A	32808747	3	1	224	1	0	0	0	0	1	0	0	0	12745	797	28	4	14	4	PSMB8	6	32808747	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	948481	32808747	138306320	60	41183											
PHF3	23469	broad.mit.edu	37	chr6	64423243	64423243	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taataggggtaaaggggaccGccagagattttatagtgatt	13	11	13	4	1	0	2	0	1	0	1	0	4	0	3	2	4	0	1	2	4	6	7			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:64423243G>A	uc003pep.1	+	15	5785	c.5759G>A	c.(5758-5760)CGC>CAC	p.R1920H	PHF3_uc003pen.2_Missense_Mutation_p.R1832H|PHF3_uc011dxs.1_Missense_Mutation_p.R1189H	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1920					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AAAGGGGACCGCCAGAGATTT	0.418													47	81					0	0	0	0	A	64423243	A	A	64423243	3	1	224	1	0	0	0	0	1	0	0	0	11891	1087	38	1	5817	1	PHF3	6	64423243	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	31614496	64423243	106691824	61	41184											
MANEA	79694	broad.mit.edu	37	chr6	96052716	96052716	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttttaggttacttttcacaTagaaccatatagcaatcgag	13	14	7	7	1	1	1	1	0	0	1	2	2	1	1	1	1	3	3	1	1	7	8			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:96052716T>G	uc003poo.1	+	4	808	c.668T>G	c.(667-669)ATA>AGA	p.I223R		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	223	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		ACTTTTCACATAGAACCATAT	0.224													3	15					0	0	0	0	G	96052716	G	G	96052716	3	3	224	1	0	0	0	0	1	0	0	0	9274	1406	49	5	678	5	MANEA	6	96052716	Missense_Mutation	SNP	T	TCGA-CV-7102-01A-11D-2012-08	31629473	96052716	75062351	62	41185											
FIG4	9896	broad.mit.edu	37	chr6	110112620	110112620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctgtattacagcggaaaaCggcagccagcgccccgccgc	10	4	12	15	5	0	0	0	0	0	0	0	1	0	1	4	2	6	3	4	2	4	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:110112620C>T	uc003ptt.2	+	20	2437	c.2222C>T	c.(2221-2223)ACG>ATG	p.T741M	FIG4_uc011eau.1_Missense_Mutation_p.T464M	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	741					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CAGCGGAAAACGGCAGCCAGC	0.507													14	127					0	0	0	0	T	110112620	T	T	110112620	3	4	224	1	0	0	0	0	1	0	0	0	5920	536	19	1	2300	1	FIG4	6	110112620	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	14059904	110112620	61002447	63	41186											
LAMA2	3908	broad.mit.edu	37	chr6	129470160	129470160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgagcataacacatgtggcGatagctgtgatcagtgctgt	10	11	13	7	1	1	2	1	2	0	0	1	3	1	2	0	1	4	3	0	1	2	2	rs141340479	byFrequency	TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr6:129470160G>A	uc003qbn.2	+	7	1051	c.946G>A	c.(946-948)GAT>AAT	p.D316N	LAMA2_uc003qbo.2_Missense_Mutation_p.D316N	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	316	Laminin EGF-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CACATGTGGCGATAGCTGTGA	0.428													16	91					0	0	0	0	A	129470160	A	A	129470160	3	1	224	1	0	0	0	0	1	0	0	0	8646	1058	37	1	972	1	LAMA2	6	129470160	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	19357540	129470160	41644907	64	41187											
HOXA1	3198	broad.mit.edu	37	chr7	27134145	27134145	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggacttctctgaggattcctCggccttctcgtcgtttcctg	3	15	10	13	3	2	1	0	1	2	0	8	3	4	3	3	3	0	1	3	3	0	4	rs41311760		TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:27134145C>T	uc003sye.2	-	2	1016	c.922G>A	c.(922-924)GAG>AAG	p.E308K	HOXA1_uc003syd.2_3'UTR|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	308						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						GAGGATTCCTCGGCCTTCTCG	0.597													11	47					0	0	0	0	T	27134145	T	T	27134145	3	4	224	1	0	0	0	0	1	0	0	0	7327	893	31	1	89	1	HOXA1	7	27134145	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08		27134145	132004518	65	41188											
TARP	445347	broad.mit.edu	37	chr7	38305106	38305106	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtcttcatggtgttcccctCctgggatcccagaatcgtgt	6	13	10	12	1	2	1	1	0	1	1	6	2	5	2	4	2	0	1	4	2	1	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:38305106C>A	uc003tge.1	-	5	978	c.601G>T	c.(601-603)GAG>TAG	p.E201*	uc003tfz.1_Intron|TARP_uc003tgb.2_5'UTR|TARP_uc003tgc.1_5'UTR|TARP_uc003tgd.1_5'UTR|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						GTGTTCCCCTCCTGGGATCCC	0.418													41	143					2.47872e-24	5.52277e-24	1	0	A	38305106	A	A	38305106	4	1	224	1	0	0	0	0	0	1	0	0	15624	854	30	2	358	2	TARP	7	38305106	Nonsense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	11170961	38305106	120833557	66	41189											
BLVRA	644	broad.mit.edu	37	chr7	43843400	43843400	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttggaagagcgaaaggaaGatcagtatatgaaaatgaca	18	8	11	4	1	1	4	1	2	0	2	1	7	1	6	0	2	1	1	0	2	7	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:43843400G>C	uc003tir.2	+	7	669	c.586G>C	c.(586-588)GAT>CAT	p.D196H	BLVRA_uc010kxv.2_Missense_Mutation_p.D196H	NM_000712	NP_000703	P53004	BIEA_HUMAN	biliverdin reductase A precursor	196					heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			ovary(1)	1					NADH(DB00157)	GCGAAAGGAAGATCAGTATAT	0.478													28	145					0	0	0	0	C	43843400	C	C	43843400	3	2	224	1	0	0	0	0	1	0	0	0	1454	942	33	2	608	2	BLVRA	7	43843400	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	5538294	43843400	115295263	67	41190											
EGFR	1956	broad.mit.edu	37	chr7	55233026	55233026	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgacggcccccactgcgtCaagacctgcccggcaggagt	8	6	12	15	3	1	2	1	1	0	1	1	3	1	3	4	3	2	1	4	3	1	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:55233026C>T	uc003tqk.2	+	15	2022	c.1776C>T	c.(1774-1776)GTC>GTT	p.V592V	EGFR_uc003tqi.2_Silent_p.V592V|EGFR_uc003tqj.2_Silent_p.V592V|EGFR_uc010kzg.1_Silent_p.V547V|EGFR_uc011kco.1_Silent_p.V539V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	592	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCCACTGCGTCAAGACCTGCC	0.547		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			23	607					0	0	0	0	T	55233026	T	T	55233026	2	4	224	1	0	0	0	0	0	0	0	1	4989	813	29	2		2	EGFR	7	55233026	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	11389626	55233026	103905637	68	41191											
SBDS	51119	broad.mit.edu	37	chr7	66456261	66456261	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgttctatcttcattttctCttttaactgctttatcactt	7	22	2	10	1	5	0	2	0	3	0	6	0	5	0	0	0	2	2	0	0	3	10			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:66456261C>G	uc003tvm.1	-	4	671	c.487G>C	c.(487-489)GAG>CAG	p.E163Q		NM_016038	NP_057122	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome protein	163					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1						TTCATTTTCTCTTTTAACTGC	0.368			Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				8	26					0	0	0	0	G	66456261	G	G	66456261	3	3	224	1	0	0	0	0	1	0	0	0	13922	922	32	2	273	2	SBDS	7	66456261	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	11223235	66456261	92682402	69	41192											
NSUN5	55695	broad.mit.edu	37	chr7	72717906	72717906	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agggagcacgtggagtagacGagccgctgcagggaagggaa	12	3	19	7	3	0	1	0	0	0	1	0	6	0	5	1	4	3	4	1	4	3	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:72717906G>A	uc003txw.2	-	8	1098	c.1062C>T	c.(1060-1062)CTC>CTT	p.L354L	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Silent_p.L354L|NSUN5_uc003txx.2_Silent_p.L316L|NSUN5_uc011kev.1_Silent_p.L354L	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	354							methyltransferase activity				0		Lung NSC(55;0.163)				TGGAGTAGACGAGCCGCTGCA	0.677													7	19					0	0	0	0	A	72717906	A	A	72717906	2	1	224	1	0	0	0	0	0	0	0	1	10735	1045	37	1		1	NSUN5	7	72717906	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08	6261645	72717906	86420757	70	41193											
HIP1	3092	broad.mit.edu	37	chr7	75172176	75172176	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggaaaggctacctgtctCttcgatctgtgatttgccgg	6	15	11	9	2	2	1	0	1	2	0	4	3	2	2	2	3	2	1	2	3	2	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:75172176C>A	uc003uds.1	-	28	2925	c.2884G>T	c.(2884-2886)GAG>TAG	p.E962*	HIP1_uc011kfz.1_Nonsense_Mutation_p.E788*	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	962	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						CTACCTGTCTCTTCGATCTGT	0.572			T	PDGFRB	CMML								13	49					7.03913e-09	1.44189e-08	1	0	A	75172176	A	A	75172176	4	1	224	1	0	0	0	0	0	1	0	0	7153	922	32	2	245	2	HIP1	7	75172176	Nonsense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	2454270	75172176	83966487	71	41194											
SLC26A3	1811	broad.mit.edu	37	chr7	107408304	107408304	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaaaaatattgagcttttCacttcaccatcaaaaaattc	18	12	3	8	0	3	2	3	1	0	1	4	2	3	2	1	0	1	1	1	0	7	6			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:107408304C>T	uc003ver.2	-	19	2323	c.2112G>A	c.(2110-2112)GTG>GTA	p.V704V	SLC26A3_uc003ves.2_Silent_p.V591V	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	704	Helical; (Potential).|STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						TTGAGCTTTTCACTTCACCAT	0.328													11	29					0	0	0	0	T	107408304	T	T	107408304	2	4	224	1	0	0	0	0	0	0	0	1	14582	813	29	2		2	SLC26A3	7	107408304	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	32236128	107408304	51730359	72	41195											
SLC4A2	6522	broad.mit.edu	37	chr7	150772740	150772740	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggcagatccccctggccGtgctctttggaattttcctg	4	13	10	14	2	1	1	0	0	1	1	4	2	4	2	5	3	1	2	5	3	1	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr7:150772740G>T	uc003wit.3	+	21	3605	c.3349G>T	c.(3349-3351)GTG>TTG	p.V1117L	SLC4A2_uc011kve.1_Missense_Mutation_p.V1108L|SLC4A2_uc003wiu.3_Missense_Mutation_p.V1103L|SLC4A2_uc003wiv.3_Missense_Mutation_p.V311L|uc011kvf.1_Intron	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	1117	Membrane (anion exchange).|Helical; (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCCCTGGCCGTGCTCTTTGG	0.607													9	56					5.68852e-11	1.18433e-10	1	0	T	150772740	T	T	150772740	3	4	224	1	0	0	0	0	1	0	0	0	14718	1145	40	3	3427	3	SLC4A2	7	150772740	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	43364436	150772740	8365923	73	41196											
MSR1	4481	broad.mit.edu	37	chr8	16026358	16026358	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aactaactgagcaattcttcGtttcccacttcaggagttga	11	13	7	10	1	2	2	1	2	1	0	4	3	3	3	1	1	3	3	1	1	3	6			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr8:16026358G>A	uc003wwz.2	-	4	437	c.239C>T	c.(238-240)ACG>ATG	p.T80M	MSR1_uc010lsu.2_Missense_Mutation_p.T98M|MSR1_uc003wxa.2_Missense_Mutation_p.T80M|MSR1_uc003wxb.2_Missense_Mutation_p.T80M|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	80	Spacer (Probable).|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		GCAATTCTTCGTTTCCCACTT	0.338													30	40					0	0	0	0	A	16026358	A	A	16026358	3	1	224	1	0	0	0	0	1	0	0	0	9939	1145	40	1	1192	1	MSR1	8	16026358	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		16026358	130337664	74	41197											
ABRA	137735	broad.mit.edu	37	chr8	107782160	107782160	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtccatctccatgtccttCtggcaggcggggtggcgact	4	12	13	12	2	2	0	0	0	2	0	5	1	4	0	3	5	0	1	3	5	0	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr8:107782160C>T	uc003ymm.3	-	1	313	c.259G>A	c.(259-261)GAA>AAA	p.E87K		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	87					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CCATGTCCTTCTGGCAGGCGG	0.532													18	124					0	0	0	0	T	107782160	T	T	107782160	3	4	224	1	0	0	0	0	1	0	0	0	100	922	32	2	894	2	ABRA	8	107782160	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	91755802	107782160	38581862	75	41198											
KCNV1	27012	broad.mit.edu	37	chr8	110986443	110986443	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcgcgtgtgcgggaagcAggacagcgcctgctgcgaga	9	4	18	10	5	0	1	0	0	0	1	0	4	0	3	1	3	5	2	1	3	2	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr8:110986443A>T	uc003ynr.3	-	1	517	c.175T>A	c.(175-177)TGC>AGC	p.C59S	KCNV1_uc010mcw.2_Missense_Mutation_p.C59S	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	59	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TGCGGGAAGCAGGACAGCGCC	0.711													3	5					0	0	0	0	T	110986443	T	T	110986443	3	4	224	1	0	0	0	0	1	0	0	0	8133	188	7	5	1339	5	KCNV1	8	110986443	Missense_Mutation	SNP	A	TCGA-CV-7102-01A-11D-2012-08	3204283	110986443	35377579	76	41199											
UNC13B	10497	broad.mit.edu	37	chr9	35380621	35380621	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctaagtggcgagatggacGtctggtacaacttgggtgag	9	9	15	8	2	1	2	0	1	1	1	1	4	1	3	1	4	2	1	1	4	3	3	rs138199360		TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr9:35380621G>A	uc003zwq.2	+	17	2405	c.2113G>A	c.(2113-2115)GTC>ATC	p.V705I	UNC13B_uc003zwr.2_Missense_Mutation_p.V705I	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	705					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			CGAGATGGACGTCTGGTACAA	0.493													22	62					0	0	0	0	A	35380621	A	A	35380621	3	1	224	1	0	0	0	0	1	0	0	0	17053	1145	40	1	2179	1	UNC13B	9	35380621	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		35380621	105832810	77	41200											
C9orf3	84909	broad.mit.edu	37	chr9	97522394	97522394	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaggtgaaaaagatacttCtgataaagatggtaaccatg	18	10	9	4	0	1	4	0	2	1	2	1	4	1	4	1	2	2	1	1	2	8	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr9:97522394C>T	uc004ava.2	+	1	464	c.329C>T	c.(328-330)TCT>TTT	p.S110F	C9orf3_uc011lui.1_RNA|C9orf3_uc004aux.1_Missense_Mutation_p.S110F|C9orf3_uc004auy.2_Missense_Mutation_p.S110F|C9orf3_uc004auz.1_Missense_Mutation_p.S110F	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	110					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AAAGATACTTCTGATAAAGAT	0.408													29	97					0	0	0	0	T	97522394	T	T	97522394	3	4	224	1	0	0	0	0	1	0	0	0	2489	913	32	2	331	2	C9orf3	9	97522394	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	62141773	97522394	43691037	78	41201											
SLC31A1	1317	broad.mit.edu	37	chr9	116022567	116022567	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccaggcaacagatgctgagCtttcctcacctcctgcaaac	10	9	7	15	0	1	2	1	1	0	1	4	2	4	2	4	1	5	4	4	1	2	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr9:116022567C>T	uc004bgu.2	+	5	573	c.387C>T	c.(385-387)AGC>AGT	p.S129S	FKBP15_uc010muu.1_Intron|SLC31A1_uc004bgv.3_Silent_p.S129S	NM_001859	NP_001850	O15431	COPT1_HUMAN	solute carrier family 31 (copper transporters),	129	Cytoplasmic (Potential).					integral to plasma membrane	copper ion transmembrane transporter activity				0						AGATGCTGAGCTTTCCTCACC	0.498													20	84					0	0	0	0	T	116022567	T	T	116022567	2	4	224	1	0	0	0	0	0	0	0	1	14627	796	28	4		4	SLC31A1	9	116022567	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	18500173	116022567	25190864	79	41202											
CUBN	8029	broad.mit.edu	37	chr10	16911693	16911693	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctgaaatgaatctgtcttGaacaccaggagcatactatt	13	12	8	8	0	3	3	0	3	3	0	3	4	3	4	1	1	3	1	1	1	5	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr10:16911693G>A	uc001ioo.2	-	59	9448	c.9396C>T	c.(9394-9396)TTC>TTT	p.F3132F	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Silent_p.F488F	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3132	CUB 23.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AATCTGTCTTGAACACCAGGA	0.453													37	147					0	0	0	0	A	16911693	A	A	16911693	2	1	224	1	0	0	0	0	0	0	0	1	4068	1281	45	2		2	CUBN	10	16911693	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08		16911693	118623054	80	41203											
C11orf41	25758	broad.mit.edu	37	chr11	33667250	33667250	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agactgagcctgaaatcataGaggaaaccaacattgacaga	18	6	9	8	0	1	6	1	3	0	3	1	7	1	7	2	1	3	0	2	1	4	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr11:33667250G>A	uc001mup.3	+	16	4679	c.4555G>A	c.(4555-4557)GAG>AAG	p.E1519K		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1513						integral to membrane				ovary(2)	2						TGAAATCATAGAGGAAACCAA	0.463													27	84					0	0	0	0	A	33667250	A	A	33667250	3	1	224	1	0	0	0	0	1	0	0	0	1646	943	33	2	4617	2	C11orf41	11	33667250	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		33667250	101339266	81	41204											
RASGRP2	10235	broad.mit.edu	37	chr11	64508539	64508539	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaaactccgctgggaaggcGgagatccagtacctggagga	11	6	14	10	2	1	1	1	0	0	1	3	5	3	4	3	5	2	2	3	5	3	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr11:64508539G>A	uc009ypu.2	-	5	479	c.252C>T	c.(250-252)TCC>TCT	p.S84S	RASGRP2_uc001oat.2_5'Flank|RASGRP2_uc001oau.2_5'UTR|RASGRP2_uc009ypv.2_Silent_p.S84S|RASGRP2_uc009ypw.2_Silent_p.S84S	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	84	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						CTGGGAAGGCGGAGATCCAGT	0.572											OREG0004006	type=REGULATORY REGION|Gene=RASGRP2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	24					0	0	0	0	A	64508539	A	A	64508539	2	1	224	1	0	0	0	0	0	0	0	1	13140	1103	39	1		1	RASGRP2	11	64508539	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08	30841289	64508539	70497977	82	41205											
CDC42BPG	55561	broad.mit.edu	37	chr11	64606237	64606237	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccgctcccagtccacgccTtcgaagaaaggatggttccg	9	7	11	14	4	0	1	0	0	0	1	4	3	3	2	5	2	1	2	5	2	2	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr11:64606237T>C	uc001obs.3	-	8	1014	c.1014A>G	c.(1012-1014)GAA>GAG	p.E338E		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	338	AGC-kinase C-terminal.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						AGTCCACGCCTTCGAAGAAAG	0.637													29	66					0	0	0	0	C	64606237	C	C	64606237	2	2	224	1	0	0	0	0	0	0	0	1	3089	1606	56	5		5	CDC42BPG	11	64606237	Silent	SNP	T	TCGA-CV-7102-01A-11D-2012-08	97698	64606237	70400279	83	41206											
OMP	4975	broad.mit.edu	37	chr11	76813990	76813990	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggagagcctgaagcagcgCggggagaagcgccaggatgg	10	3	20	8	3	0	3	0	1	0	2	0	6	0	4	2	5	4	1	2	5	2	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr11:76813990C>T	uc010rsk.1	+	1	105	c.105C>T	c.(103-105)CGC>CGT	p.R35R	CAPN5_uc001oxx.2_Intron|CAPN5_uc009yup.2_Intron|CAPN5_uc009yuq.2_Intron|CAPN5_uc001oxy.2_Intron	NM_006189	NP_006180	P47874	OMP_HUMAN	olfactory marker protein	35					sensory perception of smell|synaptic transmission						0						TGAAGCAGCGCGGGGAGAAGC	0.672													17	27					0	0	0	0	T	76813990	T	T	76813990	2	4	224	1	0	0	0	0	0	0	0	1	10921	755	27	1		1	OMP	11	76813990	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	12207753	76813990	58192526	84	41207											
CDKN1B	1027	broad.mit.edu	37	chr12	12870859	12870859	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaccccaagccctcggcctGcaggaacctcttcggcccgg	6	5	11	19	3	1	0	0	0	1	0	3	1	1	1	6	4	3	2	6	4	2	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:12870859G>T	uc001rat.2	+	1	558	c.86G>T	c.(85-87)TGC>TTC	p.C29F		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	29					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		CCCTCGGCCTGCAGGAACCTC	0.617									Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				37	71					1.90571e-15	4.149e-15	1	0	T	12870859	T	T	12870859	3	4	224	1	0	0	0	0	1	0	0	0	3174	1319	46	4	88	4	CDKN1B	12	12870859	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		12870859	120981036	85	41208											
SLCO1B3	28234	broad.mit.edu	37	chr12	21032551	21032551	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatcagttgccggcctaacCttgacctatgatgggtttgt	9	13	10	9	1	1	2	1	2	0	0	1	2	1	2	4	2	2	2	4	2	3	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:21032551C>T	uc001rek.2	+	10	1443	c.1317C>T	c.(1315-1317)ACC>ACT	p.T439T	SLCO1B3_uc001rel.2_Silent_p.T439T|SLCO1B3_uc010sil.1_Silent_p.T439T|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Silent_p.T264T	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	439	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CCGGCCTAACCTTGACCTATG	0.313													18	47					0	0	0	0	T	21032551	T	T	21032551	2	4	224	1	0	0	0	0	0	0	0	1	14788	668	24	4		4	SLCO1B3	12	21032551	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	8161692	21032551	112819344	86	41209											
GYS2	2998	broad.mit.edu	37	chr12	21693480	21693480	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcaagaatcatctggagaaCggaaccgcctgtcaacgatg	13	7	11	10	3	3	2	2	0	1	2	3	5	3	3	2	2	4	1	2	2	5	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:21693480C>T	uc001rfb.2	-	14	1928	c.1673G>A	c.(1672-1674)CGT>CAT	p.R558H		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	558					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						ATCTGGAGAACGGAACCGCCT	0.418													16	101					0	0	0	0	T	21693480	T	T	21693480	3	4	224	1	0	0	0	0	1	0	0	0	6952	536	19	1	450	1	GYS2	12	21693480	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	660929	21693480	112158415	87	41210											
CNTN1	1272	broad.mit.edu	37	chr12	41421672	41421672	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcacagctcctagccagccTccaaggatcatcagttcagt	10	10	7	14	0	4	0	4	0	0	0	6	1	6	1	4	1	3	2	4	1	2	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:41421672T>A	uc001rmm.1	+	22	2837	c.2724T>A	c.(2722-2724)CCT>CCA	p.P908P	CNTN1_uc001rmn.1_Silent_p.P897P	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	908	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CTAGCCAGCCTCCAAGGATCA	0.408													20	31					0	0	0	0	A	41421672	A	A	41421672	2	1	224	1	0	0	0	0	0	0	0	1	3655	1538	54	5		5	CNTN1	12	41421672	Silent	SNP	T	TCGA-CV-7102-01A-11D-2012-08	19728192	41421672	92430223	88	41211											
CALCOCO1	57658	broad.mit.edu	37	chr12	54115808	54115808	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctacctggcccagctcccaCcttgtactgttccatcagct	6	11	6	18	0	1	0	1	0	0	0	3	0	3	0	6	1	4	4	6	1	2	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:54115808C>T	uc001sef.2	-	5	753	c.609_splice	c.e5+1	p.K203_splice	CALCOCO1_uc010som.1_Splice_Site_p.K170_splice|CALCOCO1_uc010son.1_Splice_Site_p.K80_splice|CALCOCO1_uc001seh.2_Splice_Site_p.K203_splice|CALCOCO1_uc009znd.2_Splice_Site_p.K203_splice|CALCOCO1_uc001seg.2_Splice_Site_p.K80_splice|CALCOCO1_uc010soo.1_Splice_Site_p.K196_splice	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform						steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CCAGCTCCCACCTTGTACTGT	0.597													8	68					0	0	0	0	T	54115808	T	T	54115808	5	4	224	1	0	0	0	0	0	0	1	0	2589	521	18	4	1509	4	CALCOCO1	12	54115808	Splice_Site	SNP	C	TCGA-CV-7102-01A-11D-2012-08	12694136	54115808	79736087	89	41212											
CALCOCO1	57658	broad.mit.edu	37	chr12	54117433	54117433	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcagagcccccatcagcctCctccagggtcaccagttcat	8	8	8	17	0	4	1	4	0	0	1	6	1	6	1	6	1	2	1	6	1	0	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:54117433C>T	uc001sef.2	-	4	538	c.394G>A	c.(394-396)GAG>AAG	p.E132K	CALCOCO1_uc010som.1_Missense_Mutation_p.E99K|CALCOCO1_uc010son.1_Missense_Mutation_p.E9K|CALCOCO1_uc001seh.2_Missense_Mutation_p.E132K|CALCOCO1_uc009znd.2_Missense_Mutation_p.E132K|CALCOCO1_uc001seg.2_Missense_Mutation_p.E9K|CALCOCO1_uc010soo.1_Missense_Mutation_p.E125K	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	132	N-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CCATCAGCCTCCTCCAGGGTC	0.577													8	66					0	0	0	0	T	54117433	T	T	54117433	3	4	224	1	0	0	0	0	1	0	0	0	2589	864	30	2	1729	2	CALCOCO1	12	54117433	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	1625	54117433	79734462	90	41213											
TRHDE	29953	broad.mit.edu	37	chr12	72680609	72680609	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatgccagtggaaacttccGtgtttgaggaagatggatgg	11	11	14	5	1	0	2	0	1	0	1	1	5	1	5	2	4	2	1	2	4	3	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:72680609G>A	uc001sxa.2	+	2	958	c.928G>A	c.(928-930)GTG>ATG	p.V310M		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	310	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GGAAACTTCCGTGTTTGAGGA	0.403													56	85					0	0	0	0	A	72680609	A	A	72680609	3	1	224	1	0	0	0	0	1	0	0	0	16546	1145	40	1	934	1	TRHDE	12	72680609	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	18563176	72680609	61171286	91	41214											
CIT	11113	broad.mit.edu	37	chr12	120172977	120172977	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccttacttgcttctggctGgtaagctgcatctctcgttc	4	16	8	13	1	2	0	0	0	2	0	6	0	3	0	1	2	4	6	1	2	2	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:120172977G>A	uc001txi.1	-	24	3071	c.3018C>T	c.(3016-3018)ACC>ACT	p.T1006T	CIT_uc001txh.1_Silent_p.T540T|CIT_uc001txj.1_Silent_p.T1048T	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1006	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GCTTCTGGCTGGTAAGCTGCA	0.522													16	79					0	0	0	0	A	120172977	A	A	120172977	2	1	224	1	0	0	0	0	0	0	0	1	3453	1335	47	4		4	CIT	12	120172977	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08	47492368	120172977	13678918	92	41215											
CAMKK2	10645	broad.mit.edu	37	chr12	121691083	121691083	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcccaagcttaccttcccaGagaagatcttgcgggtctca	9	9	10	13	1	2	2	1	0	2	2	4	3	3	2	3	2	3	1	3	2	3	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:121691083G>C	uc001tzu.2	-	10	1224	c.1100C>G	c.(1099-1101)TCT>TGT	p.S367C	CAMKK2_uc001tzt.2_Missense_Mutation_p.S367C|CAMKK2_uc001tzv.2_Missense_Mutation_p.S367C|CAMKK2_uc001tzw.2_Missense_Mutation_p.S367C|CAMKK2_uc001tzx.2_Missense_Mutation_p.S367C|CAMKK2_uc001tzy.2_Missense_Mutation_p.S367C|CAMKK2_uc001tzz.1_Missense_Mutation_p.S154C|CAMKK2_uc001uaa.1_Missense_Mutation_p.S367C|CAMKK2_uc001uab.2_Missense_Mutation_p.S367C|CAMKK2_uc001uac.2_Missense_Mutation_p.S367C	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase	367	Protein kinase.				calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TACCTTCCCAGAGAAGATCTT	0.433													4	56					0	0	0	0	C	121691083	C	C	121691083	3	2	224	1	0	0	0	0	1	0	0	0	2619	942	33	2	708	2	CAMKK2	12	121691083	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	1518106	121691083	12160812	93	41216											
DNAH10	196385	broad.mit.edu	37	chr12	124413860	124413860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgggctgaaactcaacatGagggcaacttacttcaagat	15	9	9	8	0	2	3	2	2	0	1	2	3	2	3	0	2	4	2	0	2	6	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr12:124413860G>A	uc001uft.3	+	70	12016	c.11991G>A	c.(11989-11991)ATG>ATA	p.M3997I	DNAH10_uc001ufu.3_5'UTR	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3997	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AACTCAACATGAGGGCAACTT	0.537													4	16					0	0	0	0	A	124413860	A	A	124413860	3	1	224	1	0	0	0	0	1	0	0	0	4620	1290	45	2	12269	2	DNAH10	12	124413860	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	2722777	124413860	9438035	94	41217											
C13orf28	122258	broad.mit.edu	37	chr13	113030784	113030784	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagctccggccgagaaccGtgattccaggtagggcccca	8	6	13	14	3	0	3	0	2	0	1	2	4	2	3	6	3	2	2	6	3	2	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr13:113030784G>A	uc001vsd.1	+	1	116	c.85G>A	c.(85-87)GTG>ATG	p.V29M		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor	29						extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)					GCCGAGAACCGTGATTCCAGG	0.592													17	10					0	0	0	0	A	113030784	A	A	113030784	3	1	224	1	0	0	0	0	1	0	0	0	1730	1145	40	1	87	1	C13orf28	13	113030784	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		113030784	2139094	95	41218											
OR4M1	441670	broad.mit.edu	37	chr14	20248671	20248671	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctcctatgtatttcctgttgGctaatctggccctccttgat	5	17	7	12	0	1	1	0	1	1	0	4	1	4	1	4	2	0	3	4	2	3	6	rs114064896	byFrequency	TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:20248671G>T	uc010tku.1	+	1	190	c.190G>T	c.(190-192)GCT>TCT	p.A64S		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTCCTGTTGGCTAATCTGGC	0.408													28	442					2.61193e-14	5.59071e-14	1	0	T	20248671	T	T	20248671	3	4	224	1	0	0	0	0	1	0	0	0	11129	1203	42	4	192	4	OR4M1	14	20248671	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		20248671	87100869	96	41219											
METT11D1	64745	broad.mit.edu	37	chr14	21464085	21464085	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagaagtcacctttggaccCtcgacctggttttgtctttg	7	14	10	10	1	2	1	1	0	1	1	3	4	2	2	3	2	0	1	3	2	1	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:21464085C>A	uc001vyn.2	+	11	1168	c.971C>A	c.(970-972)CCT>CAT	p.P324H	METT11D1_uc001vym.2_Missense_Mutation_p.P324H|METT11D1_uc001vyo.2_Missense_Mutation_p.P324H|METT11D1_uc001vyp.2_Missense_Mutation_p.P166H|METT11D1_uc001vyq.2_Missense_Mutation_p.P166H	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	324					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		CCTTTGGACCCTCGACCTGGT	0.453													15	454					1.99824e-07	4.07127e-07	1	0	A	21464085	A	A	21464085	3	1	224	1	0	0	0	0	1	0	0	0	9544	681	24	4	1013	4	METT11D1	14	21464085	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	1215414	21464085	85885455	97	41220											
NID2	22795	broad.mit.edu	37	chr14	52481133	52481133	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggaggggtcacatctggccGgggcgtgggccggaccatgg	5	6	20	10	3	2	0	1	0	1	0	2	2	2	2	3	9	0	0	3	9	0	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:52481133G>T	uc001wzo.2	-	16	3526	c.3292C>A	c.(3292-3294)CGG>AGG	p.R1098R	NID2_uc010tqs.1_Silent_p.R1050R|NID2_uc010tqt.1_Silent_p.R1098R|NID2_uc001wzp.2_Silent_p.R1098R	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1098						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					ACATCTGGCCGGGGCGTGGGC	0.617											OREG0022678	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	30					2.37509e-13	5.05536e-13	1	0	T	52481133	T	T	52481133	2	4	224	1	0	0	0	0	0	0	0	1	10469	1115	39	3		3	NID2	14	52481133	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08	31017048	52481133	54868407	98	41221											
DAAM1	23002	broad.mit.edu	37	chr14	59791160	59791160	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attaagggaacacgaaaattCaacattagataggtaagtca	19	9	8	5	1	2	1	2	0	0	1	2	3	2	2	0	2	2	1	0	2	8	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:59791160C>G	uc001xdz.1	+	8	1102	c.977C>G	c.(976-978)TCA>TGA	p.S326*	DAAM1_uc001xea.1_Nonsense_Mutation_p.S326*|DAAM1_uc001xeb.1_Nonsense_Mutation_p.S326*	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	326	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CACGAAAATTCAACATTAGAT	0.308													3	49					0	0	0	0	G	59791160	G	G	59791160	4	3	224	1	0	0	0	0	0	1	0	0	4232	838	29	2	1003	2	DAAM1	14	59791160	Nonsense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	7310027	59791160	47558380	99	41222											
DCAF4	26094	broad.mit.edu	37	chr14	73408452	73408452	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttttttgtaataaatataGattgccaggatgggatttaa	13	17	8	3	0	1	1	0	0	1	1	1	3	1	3	1	2	1	1	1	2	6	10			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:73408452G>C	uc001xng.2	+	5	572	c.352_splice	c.e5-1	p.I118_splice	DCAF4_uc001xnj.2_Splice_Site_p.I118_splice|DCAF4_uc010ttr.1_Splice_Site_p.I96_splice|DCAF4_uc001xnh.2_Splice_Site_p.I18_splice|DCAF4_uc010tts.1_Intron|DCAF4_uc010ttt.1_Splice_Site|DCAF4_uc001xni.2_Intron|DCAF4_uc001xnk.2_Splice_Site_p.I118_splice	NM_015604	NP_056419	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4 isoform 1							CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)|skin(1)	3						AATAAATATAGATTGCCAGGA	0.368													39	75					0	0	0	0	C	73408452	C	C	73408452	5	2	224	1	0	0	0	0	0	0	1	0	4287	956	33	2	365	2	DCAF4	14	73408452	Splice_Site	SNP	G	TCGA-CV-7102-01A-11D-2012-08	13617292	73408452	33941088	100	41223											
OTUB2	78990	broad.mit.edu	37	chr14	94511065	94511065	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcggccttcatcaggaaccGagcagacttcttccggcact	8	9	10	14	3	3	1	2	0	1	1	5	3	4	2	3	3	2	2	3	3	1	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:94511065G>A	uc001yci.2	+	5	597	c.437G>A	c.(436-438)CGA>CAA	p.R146Q		NM_023112	NP_075601	Q96DC9	OTUB2_HUMAN	OTU domain, ubiquitin aldehyde binding 2	146	OTU.				cellular amino acid metabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination		omega peptidase activity|protein binding|ubiquitin-specific protease activity				0		all_cancers(154;0.12)		Epithelial(152;0.124)|all cancers(159;0.21)|COAD - Colon adenocarcinoma(157;0.215)		ATCAGGAACCGAGCAGACTTC	0.587													19	25					0	0	0	0	A	94511065	A	A	94511065	3	1	224	1	0	0	0	0	1	0	0	0	11366	1058	37	1	455	1	OTUB2	14	94511065	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	21102613	94511065	12838475	101	41224											
TCL1A	8115	broad.mit.edu	37	chr14	96178699	96178699	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggacgacgtcttcccgaCgcaagagcacccgtaactgt	10	6	10	15	5	1	1	0	0	1	1	2	4	2	2	3	1	2	3	3	1	2	2	rs146705048	byFrequency	TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr14:96178699C>T	uc001yfc.3	-	2	285	c.155G>A	c.(154-156)CGT>CAT	p.R52H	TCL1A_uc001yfb.3_Missense_Mutation_p.R52H	NM_001098725	NP_001092195	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	52					multicellular organismal development	endoplasmic reticulum|microsome				lung(1)	1		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		GTCTTCCCGACGCAAGAGCAC	0.567			T	TRA@	T-CLL								21	96					0	0	0	0	T	96178699	T	T	96178699	3	4	224	1	0	0	0	0	1	0	0	0	15770	536	19	1	197	1	TCL1A	14	96178699	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	1667634	96178699	11170841	102	41225											
DUOX1	53905	broad.mit.edu	37	chr15	45433157	45433157	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctagagctgctccctggggGactcctggagagccaccggg	6	6	16	13	1	0	2	0	0	0	2	2	4	2	3	4	4	3	3	4	4	1	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:45433157G>A	uc001zus.1	+	14	1800	c.1454G>A	c.(1453-1455)GGA>GAA	p.G485E	DUOX1_uc001zut.1_Missense_Mutation_p.G485E|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	485	Peroxidase-like; mediates peroxidase activity.|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CTCCCTGGGGGACTCCTGGAG	0.572													27	79					0	0	0	0	A	45433157	A	A	45433157	3	1	224	1	0	0	0	0	1	0	0	0	4822	1174	41	2	1500	2	DUOX1	15	45433157	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		45433157	57098235	103	41226											
MYO5A	4644	broad.mit.edu	37	chr15	52632529	52632529	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggctctggatctccccaCggagggcctcggcctcattc	5	9	11	16	2	4	0	2	0	2	0	7	2	4	2	4	5	0	1	4	5	0	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:52632529C>A	uc002aby.2	-	32	4347	c.4103G>T	c.(4102-4104)CGT>CTT	p.R1368L	MYO5A_uc002abx.3_Missense_Mutation_p.R1341L|MYO5A_uc010ugd.1_Missense_Mutation_p.R90L|MYO5A_uc002abz.1_RNA|MYO5A_uc002aca.1_Missense_Mutation_p.R120L|MYO5A_uc002acb.1_Missense_Mutation_p.R93L|MYO5A_uc002acc.1_Missense_Mutation_p.R117L	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1368	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GATCTCCCCACGGAGGGCCTC	0.637													19	82					5.03518e-11	1.05407e-10	1	0	A	52632529	A	A	52632529	3	1	224	1	0	0	0	0	1	0	0	0	10131	536	19	3	1504	3	MYO5A	15	52632529	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	7199372	52632529	49898863	104	41227											
HERC1	8925	broad.mit.edu	37	chr15	63978604	63978604	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcctgtagatgccaatccaTatcctttccctccactgccg	7	12	5	17	1	0	1	0	0	0	1	5	1	5	1	7	0	2	1	7	0	3	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:63978604T>C	uc002amp.2	-	34	6327	c.6179A>G	c.(6178-6180)TAT>TGT	p.Y2060C		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2060	B30.2/SPRY.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TGCCAATCCATATCCTTTCCC	0.408													80	143					0	0	0	0	C	63978604	C	C	63978604	3	2	224	1	0	0	0	0	1	0	0	0	7096	1406	49	5	8586	5	HERC1	15	63978604	Missense_Mutation	SNP	T	TCGA-CV-7102-01A-11D-2012-08	11346075	63978604	38552788	105	41228											
C15orf44	81556	broad.mit.edu	37	chr15	65888131	65888131	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactgggggacttgaaatatCagctatatcaataaatccca	16	10	7	8	0	2	1	2	1	0	0	3	2	3	2	1	2	2	1	1	2	8	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:65888131C>T	uc002apd.2	-	7	1117	c.781G>A	c.(781-783)GAT>AAT	p.D261N	C15orf44_uc010uix.1_Missense_Mutation_p.D297N|C15orf44_uc010uiz.1_Missense_Mutation_p.D225N|C15orf44_uc010uja.1_Missense_Mutation_p.D212N|C15orf44_uc010ujb.1_Missense_Mutation_p.D182N|C15orf44_uc002ape.3_Missense_Mutation_p.D261N|C15orf44_uc010uiy.1_Missense_Mutation_p.D182N	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2	261										ovary(1)	1						CTTGAAATATCAGCTATATCA	0.353													7	32					0	0	0	0	T	65888131	T	T	65888131	3	4	224	1	0	0	0	0	1	0	0	0	1804	826	29	2	799	2	C15orf44	15	65888131	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	1909527	65888131	36643261	106	41229											
MYO9A	4649	broad.mit.edu	37	chr15	72244166	72244166	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatctctaagctcctctggtGgactgggtgttggagaaagc	9	11	13	8	0	2	1	0	0	2	1	4	3	3	2	1	4	2	2	1	4	3	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:72244166G>A	uc002atl.3	-	15	2727	c.2254C>T	c.(2254-2256)CAC>TAC	p.H752Y	MYO9A_uc010biq.2_Missense_Mutation_p.H347Y|MYO9A_uc002atn.1_Missense_Mutation_p.H733Y	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	752					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						CTCCTCTGGTGGACTGGGTGT	0.373													24	134					0	0	0	0	A	72244166	A	A	72244166	3	1	224	1	0	0	0	0	1	0	0	0	10137	1348	47	4	5504	4	MYO9A	15	72244166	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	6356035	72244166	30287226	107	41230											
PKM2	5315	broad.mit.edu	37	chr15	72509817	72509817	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttaatcatctccttcaacGtctccactgatcgggaagct	10	12	6	13	2	4	1	2	1	2	0	7	2	4	2	2	1	2	1	2	1	3	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:72509817G>A	uc002atx.1	-	3	420	c.179C>T	c.(178-180)ACG>ATG	p.T60M	PKM2_uc010bit.1_Missense_Mutation_p.T65M|PKM2_uc010uki.1_Missense_Mutation_p.T134M|PKM2_uc002atv.1_Missense_Mutation_p.T95M|PKM2_uc002atw.1_Missense_Mutation_p.T60M|PKM2_uc002aty.1_Missense_Mutation_p.T60M|PKM2_uc010ukj.1_Intron|PKM2_uc010ukk.1_Intron|PKM2_uc010biu.1_Missense_Mutation_p.T81M|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	60					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	CTCCTTCAACGTCTCCACTGA	0.408													13	69					0	0	0	0	A	72509817	A	A	72509817	3	1	224	1	0	0	0	0	1	0	0	0	12032	1145	40	1	1623	1	PKM2	15	72509817	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	265651	72509817	30021575	108	41231											
ARIH1	25820	broad.mit.edu	37	chr15	72873104	72873104	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccctgcagaggtacctgttCtactgtaatcgctatatgaa	10	12	9	10	1	1	2	0	1	1	1	2	2	1	2	2	1	3	5	2	1	6	6			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr15:72873104C>G	uc002aut.3	+	12	1562	c.1248C>G	c.(1246-1248)TTC>TTG	p.F416L		NM_005744	NP_005735	Q9Y4X5	ARI1_HUMAN	ariadne ubiquitin-conjugating enzyme E2 binding	416					ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding				0						GGTACCTGTTCTACTGTAATC	0.413													7	43					0	0	0	0	G	72873104	G	G	72873104	3	3	224	1	0	0	0	0	1	0	0	0	923	912	32	2	1294	2	ARIH1	15	72873104	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	363287	72873104	29658288	109	41232											
TSC2	7249	broad.mit.edu	37	chr16	2121792	2121792	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgcttctgcagggagccaGagagaggctctgagaagaag	11	7	15	8	0	2	4	0	1	2	4	2	7	2	5	1	2	3	3	1	2	2	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:2121792G>C	uc002con.2	+	19	2060	c.1954G>C	c.(1954-1956)GAG>CAG	p.E652Q	TSC2_uc010bsd.2_Missense_Mutation_p.E652Q|TSC2_uc002coo.2_Missense_Mutation_p.E652Q|TSC2_uc010uvv.1_Missense_Mutation_p.E615Q|TSC2_uc010uvw.1_Missense_Mutation_p.E603Q|TSC2_uc002cop.2_Missense_Mutation_p.E452Q	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	652					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CAGGGAGCCAGAGAGAGGCTC	0.662			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				3	13					0	0	0	0	C	2121792	C	C	2121792	3	2	224	1	0	0	0	0	1	0	0	0	16673	943	33	2	2024	2	TSC2	16	2121792	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		2121792	88232961	110	41233											
TRAF7	84231	broad.mit.edu	37	chr16	2218133	2218133	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acaccctcctcctccagcacCcttgcctactccccgcggga	6	7	6	22	2	0	0	0	0	0	0	4	1	4	1	8	1	3	1	8	1	1	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:2218133C>T	uc002cow.2	+	4	294	c.195C>T	c.(193-195)ACC>ACT	p.T65T		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	65					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						CCTCCAGCACCCTTGCCTACT	0.672													5	17					0	0	0	0	T	2218133	T	T	2218133	2	4	224	1	0	0	0	0	0	0	0	1	16513	610	22	4		4	TRAF7	16	2218133	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	96341	2218133	88136620	111	41234											
TAOK2	9344	broad.mit.edu	37	chr16	30002132	30002132	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgatgagacccaggaggcaGagttccaggcccttcggcag	9	7	14	11	1	0	3	0	2	0	2	2	5	1	4	3	4	0	3	3	4	0	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:30002132G>A	uc002dvc.1	+	18	3256	c.2473G>A	c.(2473-2475)GAG>AAG	p.E825K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron	NM_004783	NP_004774	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 1	704	Potential.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CCAGGAGGCAGAGTTCCAGGC	0.602													9	54					0	0	0	0	A	30002132	A	A	30002132	3	1	224	1	0	0	0	0	1	0	0	0	15614	943	33	2	4015	2	TAOK2	16	30002132	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	27783999	30002132	60352621	112	41235											
CTCF	10664	broad.mit.edu	37	chr16	67660529	67660529	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttactgtgatgctgtgtttCatgagcgctatgccctcatc	6	15	10	10	1	2	2	2	2	0	0	3	2	2	2	1	0	4	4	1	0	2	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:67660529C>T	uc002etl.2	+	8	1719	c.1429C>T	c.(1429-1431)CAT>TAT	p.H477Y	CTCF_uc010cek.2_Missense_Mutation_p.H149Y|CTCF_uc002etm.1_5'Flank	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	477	C2H2-type 8.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		TGCTGTGTTTCATGAGCGCTA	0.463													11	48					0	0	0	0	T	67660529	T	T	67660529	3	4	224	1	0	0	0	0	1	0	0	0	4017	826	29	2	1451	2	CTCF	16	67660529	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	37658397	67660529	22694224	113	41236											
CDH13	1012	broad.mit.edu	37	chr16	83159053	83159053	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agaggtccattgtggtatctCccattttaattccagagaat	11	14	8	8	0	1	2	0	0	1	2	4	3	3	2	3	2	0	1	3	2	3	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:83159053C>T	uc002fgx.2	+	4	550	c.430C>T	c.(430-432)CCC>TCC	p.P144S	CDH13_uc010chh.2_Missense_Mutation_p.P144S|CDH13_uc010vns.1_Missense_Mutation_p.P191S|CDH13_uc010vnt.1_5'UTR|CDH13_uc010vnu.1_Intron	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	144	Cadherin 1.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TGTGGTATCTCCCATTTTAAT	0.363													14	28					0	0	0	0	T	83159053	T	T	83159053	3	4	224	1	0	0	0	0	1	0	0	0	3114	855	30	2	444	2	CDH13	16	83159053	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	15498524	83159053	7195700	114	41237											
FBXO31	79791	broad.mit.edu	37	chr16	87365041	87365041	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacccgaagcggtcctcatcGaagaggatgaagaccccggg	12	4	13	12	4	1	3	1	1	0	2	3	6	2	4	4	3	2	0	4	3	4	0	rs141426651		TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr16:87365041G>A	uc002fjw.2	-	9	1517	c.1473C>T	c.(1471-1473)TTC>TTT	p.F491F	FBXO31_uc010vot.1_Silent_p.F319F|FBXO31_uc002fjv.2_Silent_p.F383F	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	491					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		GGTCCTCATCGAAGAGGATGA	0.612													11	24					0	0	0	0	A	87365041	A	A	87365041	2	1	224	1	0	0	0	0	0	0	0	1	5773	1049	37	1		1	FBXO31	16	87365041	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08	4205988	87365041	2989712	115	41238											
ASGR1	432	broad.mit.edu	37	chr17	7077514	7077514	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctccagccggcagtagttGtcggcgtcagcccaggcctt	5	9	12	15	3	1	0	1	0	0	0	4	0	3	0	5	3	2	3	5	3	1	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:7077514G>T	uc002ges.3	-	7	947	c.537C>A	c.(535-537)GAC>GAA	p.D179E	ASGR1_uc010clx.1_Missense_Mutation_p.D78E	NM_001671	NP_001662	P07306	ASGR1_HUMAN	asialoglycoprotein receptor 1	179	Extracellular (Probable).|C-type lectin.				receptor-mediated endocytosis	integral to plasma membrane	asialoglycoprotein receptor activity|metal ion binding|sugar binding			breast(1)|central_nervous_system(1)	2						GGCAGTAGTTGTCGGCGTCAG	0.677													42	60					4.44401e-20	9.844e-20	1	0	T	7077514	T	T	7077514	3	4	224	1	0	0	0	0	1	0	0	0	1041	1368	48	4	350	4	ASGR1	17	7077514	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		7077514	74117696	116	41239											
TP53	7157	broad.mit.edu	37	chr17	7577141	7577141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcacctcaaagctgttccgtCccagtagattaccactactc	10	10	6	15	1	1	1	1	0	0	1	4	1	3	1	4	0	3	4	4	0	4	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:7577141C>T	uc002gim.2	-	8	991	c.797G>A	c.(796-798)GGA>GAA	p.G266E	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.G266E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G134E|TP53_uc010cng.1_Missense_Mutation_p.G134E|TP53_uc002gii.1_Missense_Mutation_p.G134E|TP53_uc010cnh.1_Missense_Mutation_p.G266E|TP53_uc010cni.1_Missense_Mutation_p.G266E|TP53_uc002gij.2_Missense_Mutation_p.G266E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	266	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G266E(45)|p.G266R(42)|p.G266V(32)|p.G266*(12)|p.0?(7)|p.G266fs*79(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266G(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.G266T(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.G266fs*9(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTGTTCCGTCCCAGTAGATT	0.517		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	10					0	0	0	0	T	7577141	T	T	7577141	3	4	224	1	0	0	0	0	1	0	0	0	16448	855	30	2	489	2	TP53	17	7577141	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	499627	7577141	73618069	117	41240											
AURKB	9212	broad.mit.edu	37	chr17	8108663	8108663	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtgcatgcgcccctcaatCatctctgggggcaggtagtc	6	11	12	12	1	3	0	2	0	1	0	5	0	3	0	2	3	2	3	2	3	2	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:8108663C>T	uc002gkm.2	-	8	793	c.732G>A	c.(730-732)ATG>ATA	p.M244I	AURKB_uc010cnu.2_Missense_Mutation_p.M64I|AURKB_uc002gkn.2_Missense_Mutation_p.M245I|AURKB_uc010vuu.1_Missense_Mutation_p.M203I|AURKB_uc002gko.2_RNA	NM_004217	NP_004208	Q96GD4	AURKB_HUMAN	aurora kinase B	244	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic prometaphase|protein localization to kinetochore	chromosome passenger complex|condensed nuclear chromosome, centromeric region|cytosol|spindle	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(1)|central_nervous_system(1)	4						GCCCCTCAATCATCTCTGGGG	0.562													14	64					0	0	0	0	T	8108663	T	T	8108663	3	4	224	1	0	0	0	0	1	0	0	0	1225	826	29	2	310	2	AURKB	17	8108663	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	531522	8108663	73086547	118	41241											
GOSR1	9527	broad.mit.edu	37	chr17	28811740	28811740	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgcaggtgtcccctccttGaatgcagccctgatgcatac	8	10	10	13	0	0	2	0	2	0	0	2	2	2	2	4	1	5	3	4	1	2	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:28811740G>C	uc002hfe.2	+	4	326	c.300G>C	c.(298-300)TTG>TTC	p.L100F	GOSR1_uc002hfd.2_Missense_Mutation_p.L98F|GOSR1_uc002hff.2_Missense_Mutation_p.L35F|GOSR1_uc002hfc.1_Missense_Mutation_p.L100F	NM_004871	NP_004862	O95249	GOSR1_HUMAN	golgi SNAP receptor complex member 1 isoform 1	100	Cytoplasmic (Potential).				intra-Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|SNARE complex	SNAP receptor activity				0						TCCCCTCCTTGAATGCAGCCC	0.363													7	44					0	0	0	0	C	28811740	C	C	28811740	3	2	224	1	0	0	0	0	1	0	0	0	6614	1281	45	2	314	2	GOSR1	17	28811740	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	20703077	28811740	52383470	119	41242											
PIP4K2B	8396	broad.mit.edu	37	chr17	36927374	36927374	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggctgtccggaggtgtgccaTaggagcagagtaggttgcca	8	8	17	8	1	0	1	0	0	0	1	1	3	1	3	3	5	3	4	3	5	2	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:36927374T>A	uc002hqs.2	-	8	1440	c.959A>T	c.(958-960)TAT>TTT	p.Y320F	PIP4K2B_uc010cvp.2_5'Flank	NM_003559	NP_003550	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	320	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			ovary(1)	1						AGGTGTGCCATAGGAGCAGAG	0.448													19	47					0	0	0	0	A	36927374	A	A	36927374	3	1	224	1	0	0	0	0	1	0	0	0	11992	1406	49	5	303	5	PIP4K2B	17	36927374	Missense_Mutation	SNP	T	TCGA-CV-7102-01A-11D-2012-08	8115634	36927374	44267836	120	41243											
KRT23	25984	broad.mit.edu	37	chr17	39086308	39086308	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttcggaggccctcgacttCaatttccaagtctttcttaa	8	14	6	13	2	3	0	1	0	2	0	6	2	4	1	3	2	0	0	3	2	3	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:39086308C>G	uc002hvm.1	-	4	1109	c.520G>C	c.(520-522)GAA>CAA	p.E174Q	KRT23_uc010wfl.1_Missense_Mutation_p.E37Q|KRT23_uc010cxf.1_Intron|KRT23_uc010cxg.2_Missense_Mutation_p.E174Q|KRT23_uc002hvn.1_Missense_Mutation_p.E174Q	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	keratin 23	174	Rod.|Coil 1B.					intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)				CCCTCGACTTCAATTTCCAAG	0.443													21	95					0	0	0	0	G	39086308	G	G	39086308	3	3	224	1	0	0	0	0	1	0	0	0	8499	835	29	2	772	2	KRT23	17	39086308	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	2158934	39086308	42108902	121	41244											
DUSP3	1845	broad.mit.edu	37	chr17	41847077	41847077	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcacggttctgcctcacgAtgctcagggcagacttgacg	7	10	11	13	3	4	2	3	1	2	1	5	3	4	2	1	2	2	3	1	2	0	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:41847077A>G	uc002ied.3	-	3	534	c.458T>C	c.(457-459)ATC>ACC	p.I153T	DUSP3_uc002iee.3_3'UTR|DUSP3_uc002ief.1_Missense_Mutation_p.I110T	NM_004090	NP_004081	P51452	DUS3_HUMAN	dual specificity phosphatase 3	153	Tyrosine-protein phosphatase.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of JNK cascade|negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|immunological synapse|nucleoplasm	MAP kinase phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		Breast(137;0.00725)		BRCA - Breast invasive adenocarcinoma(366;0.116)		CTGCCTCACGATGCTCAGGGC	0.582													9	53					0	0	0	0	G	41847077	G	G	41847077	3	3	224	1	0	0	0	0	1	0	0	0	4848	333	12	5	103	5	DUSP3	17	41847077	Missense_Mutation	SNP	A	TCGA-CV-7102-01A-11D-2012-08	2760769	41847077	39348133	122	41245											
LRRC37A2	474170	broad.mit.edu	37	chr17	44626223	44626223	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaagccttccttcacccaaGagcataaggcagcagtctct	11	8	7	15	0	2	1	1	0	1	1	4	1	3	1	4	1	3	3	4	1	3	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:44626223G>C	uc002ikn.1	+	9	3721	c.3718G>C	c.(3718-3720)GAG>CAG	p.E1240Q	ARL17A_uc002iko.3_Intron|LRRC37A2_uc002ikq.1_Missense_Mutation_p.E201Q|LRRC37A2_uc010dax.1_Missense_Mutation_p.E170Q	NM_001006607	NP_001006608	A6NM11	L37A2_HUMAN	c114 SLIT-like testicular protein precursor	1240	Extracellular (Potential).					integral to membrane					0		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		CTTCACCCAAGAGCATAAGGC	0.592													17	223					0	0	0	0	C	44626223	C	C	44626223	3	2	224	1	0	0	0	0	1	0	0	0	9042	943	33	2	3752	2	LRRC37A2	17	44626223	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	2779146	44626223	36568987	123	41246											
CCDC46	201134	broad.mit.edu	37	chr17	63847958	63847958	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgtctcagcagcatgagtCtttttcagctctattttcat	7	18	6	10	0	6	1	3	1	4	0	7	1	6	1	0	0	3	3	0	0	1	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:63847958C>G	uc002jfl.2	-	21	2577	c.2358G>C	c.(2356-2358)AAG>AAC	p.K786N	CCDC46_uc010deo.2_Missense_Mutation_p.K528N|CCDC46_uc002jfm.2_Missense_Mutation_p.K786N|CCDC46_uc010dep.2_Missense_Mutation_p.K744N	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	786	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			CAGCATGAGTCTTTTTCAGCT	0.373													24	150					0	0	0	0	G	63847958	G	G	63847958	3	3	224	1	0	0	0	0	1	0	0	0	2830	912	32	2	703	2	CCDC46	17	63847958	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	19221735	63847958	17347252	124	41247											
MRPS7	51081	broad.mit.edu	37	chr17	73258060	73258060	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggcgggctgtcttgcagcttCcagggtgagagggtggcgag	5	8	20	8	2	1	1	0	1	1	1	2	3	2	1	1	5	2	3	1	5	0	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr17:73258060C>G	uc002jnm.3	+	1	312	c.79C>G	c.(79-81)CCA>GCA	p.P27A	GGA3_uc002jni.1_5'Flank|GGA3_uc002jnj.1_5'Flank|GGA3_uc010wrw.1_Intron|GGA3_uc002jnk.1_5'Flank|GGA3_uc010wrx.1_5'Flank|GGA3_uc010wry.1_Intron|GGA3_uc010wrz.1_5'Flank|MRPS7_uc002jnl.2_Missense_Mutation_p.P27A|MRPS7_uc002jnn.3_5'UTR	NM_015971	NP_057055	Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7 precursor	27					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome			central_nervous_system(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			CTTGCAGCTTCCAGGGTGAGA	0.592													10	61					0	0	0	0	G	73258060	G	G	73258060	3	3	224	1	0	0	0	0	1	0	0	0	9901	855	30	2	81	2	MRPS7	17	73258060	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	9410102	73258060	7937150	125	41248											
DTNA	1837	broad.mit.edu	37	chr18	32457760	32457760	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctatgtcctctcttgtgaaaGagctgaattctggtgagttc	8	15	10	8	0	2	4	0	3	2	1	5	4	3	4	1	1	1	2	1	1	3	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr18:32457760G>C	uc010dmn.1	+	18	1901	c.1900G>C	c.(1900-1902)GAG>CAG	p.E634Q	DTNA_uc002kxw.2_Missense_Mutation_p.E577Q|DTNA_uc010dmj.2_Missense_Mutation_p.E574Q|DTNA_uc002kxz.2_Missense_Mutation_p.E581Q|DTNA_uc002kxy.2_Missense_Mutation_p.E574Q|DTNA_uc010xby.1_Missense_Mutation_p.E324Q|DTNA_uc010xbz.1_Missense_Mutation_p.E343Q|DTNA_uc010xca.1_Missense_Mutation_p.E286Q|DTNA_uc002kye.2_Missense_Mutation_p.E282Q	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	634					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						TCTTGTGAAAGAGCTGAATTC	0.423													6	27					0	0	0	0	C	32457760	C	C	32457760	3	2	224	1	0	0	0	0	1	0	0	0	4810	943	33	2	2060	2	DTNA	18	32457760	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		32457760	45619488	126	41249											
LIPG	9388	broad.mit.edu	37	chr18	47107900	47107900	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcactgactccaatcgcttCaaaaaggggatctgtctgag	11	10	10	10	1	3	2	1	2	2	0	5	3	4	3	1	2	1	2	1	2	3	1	rs75308718		TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr18:47107900C>T	uc002ldv.2	+	6	1161	c.909C>T	c.(907-909)TTC>TTT	p.F303F	LIPG_uc002ldu.1_Silent_p.F303F|LIPG_uc010xdh.1_Silent_p.F229F	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	303					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						CCAATCGCTTCAAAAAGGGGA	0.468													17	116					0	0	0	0	T	47107900	T	T	47107900	2	4	224	1	0	0	0	0	0	0	0	1	8865	825	29	2		2	LIPG	18	47107900	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	14650140	47107900	30969348	127	41250											
WDR7	23335	broad.mit.edu	37	chr18	54358527	54358527	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaccgggggggactttgtCtcatcagataaagtcatcat	10	11	12	8	1	4	1	4	0	1	1	5	3	4	3	1	4	0	0	1	4	2	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr18:54358527C>G	uc002lgk.1	+	8	1009	c.798C>G	c.(796-798)GTC>GTG	p.V266V	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Silent_p.V266V	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	266										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GGGACTTTGTCTCATCAGATA	0.418													35	58					0	0	0	0	G	54358527	G	G	54358527	2	3	224	1	0	0	0	0	0	0	0	1	17388	900	32	2		2	WDR7	18	54358527	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	7250627	54358527	23718721	128	41251											
NFIC	4782	broad.mit.edu	37	chr19	3452481	3452481	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttcccactgtctccgcaggGatcgcccggagcccacaccc	6	6	9	20	3	1	0	0	0	1	0	4	2	2	2	5	2	1	1	5	2	0	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:3452481G>T	uc010xhi.1	+	8	1148	c.1086G>T	c.(1084-1086)GGG>GGT	p.G362G	NFIC_uc002lxo.2_Silent_p.G353G|NFIC_uc010xhh.1_Silent_p.G353G|NFIC_uc002lxp.2_Silent_p.G362G|NFIC_uc010xhj.1_Silent_p.G362G	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	362					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		TCTCCGCAGGGATCGCCCGGA	0.647													52	181					1.46156e-29	3.29499e-29	1	0	T	3452481	T	T	3452481	2	4	224	1	0	0	0	0	0	0	0	1	10426	1188	41	2		2	NFIC	19	3452481	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08		3452481	55676502	129	41252											
GIPC3	126326	broad.mit.edu	37	chr19	3586841	3586841	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaaggcagtatcatcaaccgGatcgaggcagtgtgcgtggg	10	7	16	8	3	2	0	2	0	0	0	3	3	2	1	1	4	2	3	1	4	3	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:3586841G>A	uc002lyd.3	+	3	468	c.441G>A	c.(439-441)CGG>CGA	p.R147R		NM_133261	NP_573568	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	147	PDZ.									breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		TCATCAACCGGATCGAGGCAG	0.622											OREG0025154	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	15					0	0	0	0	A	3586841	A	A	3586841	2	1	224	1	0	0	0	0	0	0	0	1	6431	1161	41	2		2	GIPC3	19	3586841	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08	134360	3586841	55542142	130	41253											
SEMA6B	10501	broad.mit.edu	37	chr19	4552583	4552583	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcaggaaggacgtccactgCttctccagcacgcgggggga	8	7	14	12	3	2	0	1	0	1	0	4	3	3	3	2	5	2	2	2	5	1	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:4552583C>T	uc010duc.1	-	9	878	c.840G>A	c.(838-840)AAG>AAA	p.K280K	SEMA6B_uc010dud.2_Silent_p.K280K|SEMA6B_uc010xih.1_Silent_p.K280K	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	280	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGTCCACTGCTTCTCCAGCA	0.657													10	12					0	0	0	0	T	4552583	T	T	4552583	2	4	224	1	0	0	0	0	0	0	0	1	14105	796	28	4		4	SEMA6B	19	4552583	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	965742	4552583	54576400	131	41254											
LRRC8E	80131	broad.mit.edu	37	chr19	7964812	7964812	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggagctcagcttgctcCactcgcccgccaggctaccc	6	7	10	18	2	1	0	1	0	0	0	3	1	2	1	4	2	5	5	4	2	1	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:7964812C>T	uc002mir.2	+	3	1506	c.1405C>T	c.(1405-1407)CAC>TAC	p.H469Y		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	469						integral to membrane				lung(1)|pancreas(1)	2						CAGCTTGCTCCACTCGCCCGC	0.632													9	22					0	0	0	0	T	7964812	T	T	7964812	3	4	224	1	0	0	0	0	1	0	0	0	9075	594	21	4	1411	4	LRRC8E	19	7964812	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	3412229	7964812	51164171	132	41255											
DAND5	199699	broad.mit.edu	37	chr19	13080346	13080346	+	5'Flank	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atgcctcccaggctatccagGaggggccaagagattaaaag	13	6	12	10	0	0	1	0	0	0	1	2	3	2	2	4	4	1	1	4	4	4	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:13080346G>C	uc002mwc.1	+						DAND5_uc010dyz.1_5'UTR	NM_152654	NP_689867	Q8N907	DAND5_HUMAN	dante precursor							extracellular region				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			GGCTATCCAGGAGGGGCCAAG	0.542													4	10					0	0	0	0	C	13080346	C	C	13080346	1	2	224	0	1	0	0	0	0	0	0	0	4247	1189	41	2		2	DAND5	19	13080346	5'Flank	SNP	G	TCGA-CV-7102-01A-11D-2012-08	5115534	13080346	46048637	133	41256											
UNC13A	23025	broad.mit.edu	37	chr19	17737530	17737530	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggctggcacattgcctgTgcccttaacctggctaagga	8	10	11	12	0	0	0	0	0	0	0	0	1	0	1	3	4	3	3	3	4	2	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:17737530T>C	uc002nhd.2	-	34	4249	c.4249A>G	c.(4249-4251)ACA>GCA	p.T1417A		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1329					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						ACATTGCCTGTGCCCTTAACC	0.592													8	12					0	0	0	0	C	17737530	C	C	17737530	3	2	224	1	0	0	0	0	1	0	0	0	17052	1696	59	5	1166	5	UNC13A	19	17737530	Missense_Mutation	SNP	T	TCGA-CV-7102-01A-11D-2012-08	4657184	17737530	41391453	134	41257											
KLHL26	55295	broad.mit.edu	37	chr19	18778789	18778789	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accttccggcacttcctgcaGatcgccgaggaggaggattt	8	9	12	12	3	0	1	0	0	0	1	3	5	2	4	4	4	1	2	4	4	0	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:18778789G>C	uc002njz.1	+	3	609	c.582G>C	c.(580-582)CAG>CAC	p.Q194H		NM_018316	NP_060786	Q53HC5	KLH26_HUMAN	kelch-like 26	194	BACK.									ovary(1)	1						ACTTCCTGCAGATCGCCGAGG	0.637													9	50					0	0	0	0	C	18778789	C	C	18778789	3	2	224	1	0	0	0	0	1	0	0	0	8420	933	33	2	592	2	KLHL26	19	18778789	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	1041259	18778789	40350194	135	41258											
ZNF101	94039	broad.mit.edu	37	chr19	19790800	19790800	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgaaagagctcacactggAgaaagaccttatgaatgtaa	17	8	9	7	0	1	5	1	2	0	3	1	6	1	5	1	1	1	2	1	1	5	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:19790800A>T	uc002nni.1	+	4	1112	c.1002A>T	c.(1000-1002)GGA>GGT	p.G334G	ZNF101_uc010ecg.1_Silent_p.G214G|ZNF101_uc002nnj.1_Silent_p.G214G	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTCACACTGGAGAAAGACCTT	0.368													6	31					0	0	0	0	T	19790800	T	T	19790800	2	4	224	1	0	0	0	0	0	0	0	1	17781	291	11	5		5	ZNF101	19	19790800	Silent	SNP	A	TCGA-CV-7102-01A-11D-2012-08	1012011	19790800	39338183	136	41259											
ZNF430	80264	broad.mit.edu	37	chr19	21239886	21239886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagaagaattcatactggaGagaaaccctacaaatgtgaa	19	7	8	7	0	1	4	1	1	0	3	1	6	1	5	1	1	3	0	1	1	7	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:21239886G>C	uc002npj.2	+	5	882	c.772G>C	c.(772-774)GAG>CAG	p.E258Q	ZNF430_uc002npk.2_Missense_Mutation_p.E257Q	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						TCATACTGGAGAGAAACCCTA	0.368													5	50					0	0	0	0	C	21239886	C	C	21239886	3	2	224	1	0	0	0	0	1	0	0	0	17971	943	33	2	790	2	ZNF430	19	21239886	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	1449086	21239886	37889097	137	41260											
FCGBP	8857	broad.mit.edu	37	chr19	40408042	40408042	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagccctcagcacacccaTcctggcactgtggaggggca	8	5	13	15	0	1	0	1	0	0	0	2	1	2	1	3	5	2	4	3	5	0	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:40408042T>A	uc002omp.3	-	9	4687	c.4679A>T	c.(4678-4680)GAT>GTT	p.D1560V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1560	TIL 3.|Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGCACACCCATCCTGGCACTG	0.617													12	40					0	0	0	0	A	40408042	A	A	40408042	3	1	224	1	0	0	0	0	1	0	0	0	5810	1435	50	5	11650	5	FCGBP	19	40408042	Missense_Mutation	SNP	T	TCGA-CV-7102-01A-11D-2012-08	19168156	40408042	18720941	138	41261											
HIF3A	64344	broad.mit.edu	37	chr19	46808523	46808523	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagtggaaccaggtgggagCagggggagaaccactggatg	11	4	20	6	0	0	1	0	0	0	1	0	6	0	5	2	7	3	1	2	7	2	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:46808523C>G	uc002peh.2	+	3	268	c.239C>G	c.(238-240)GCA>GGA	p.A80G	HIF3A_uc002pef.1_Missense_Mutation_p.A80G|HIF3A_uc002peg.3_Missense_Mutation_p.A80G|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Missense_Mutation_p.A24G|HIF3A_uc002pej.1_Intron|HIF3A_uc002pek.2_Missense_Mutation_p.A24G|HIF3A_uc010xxy.1_Intron|HIF3A_uc002pel.2_Missense_Mutation_p.A78G|HIF3A_uc010xxz.1_Intron	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CAGGTGGGAGCAGGGGGAGAA	0.617													18	81					0	0	0	0	G	46808523	G	G	46808523	3	3	224	1	0	0	0	0	1	0	0	0	7144	710	25	4	273	4	HIF3A	19	46808523	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	6400481	46808523	12320460	139	41262											
LENG8	114823	broad.mit.edu	37	chr19	54968931	54968931	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttccctttttcaggttttGaaaaagtcgctgtgcatggt	8	16	10	7	1	1	1	1	1	0	0	3	1	2	1	1	2	1	4	1	2	2	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:54968931G>C	uc002qfv.1	+	11	1770	c.1626G>C	c.(1624-1626)TTG>TTC	p.L542F	LENG8_uc002qfw.2_Missense_Mutation_p.L579F			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	542							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		TTCAGGTTTTGAAAAAGTCGC	0.493													11	87					0	0	0	0	C	54968931	C	C	54968931	3	2	224	1	0	0	0	0	1	0	0	0	8764	1281	45	2	1779	2	LENG8	19	54968931	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	8160408	54968931	4160052	140	41263											
ZNF264	9422	broad.mit.edu	37	chr19	57705330	57705330	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctcagcggaccctgtaccagGaggtgatgctggaaaactgt	10	8	13	10	1	1	1	1	1	0	0	1	4	1	4	2	4	4	2	2	4	3	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:57705330G>C	uc002qob.2	+	2	534	c.121G>C	c.(121-123)GAG>CAG	p.E41Q		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		CCTGTACCAGGAGGTGATGCT	0.557													23	107					0	0	0	0	C	57705330	C	C	57705330	3	2	224	1	0	0	0	0	1	0	0	0	17871	1175	41	2	127	2	ZNF264	19	57705330	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	2736399	57705330	1423653	141	41264											
ZNF418	147686	broad.mit.edu	37	chr19	58438232	58438232	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctgatgctgaatgaggttGccctttcgactaaaagattt	10	13	10	8	2	0	4	0	3	0	1	1	5	0	4	1	1	2	3	1	1	3	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr19:58438232G>T	uc002qqs.1	-	4	1609	c.1317C>A	c.(1315-1317)GGC>GGA	p.G439G	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Silent_p.G354G	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	439	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		GAATGAGGTTGCCCTTTCGAC	0.473													41	149					1.59361e-14	3.4498e-14	1	0	T	58438232	T	T	58438232	2	4	224	1	0	0	0	0	0	0	0	1	17962	1306	46	4		4	ZNF418	19	58438232	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08	732902	58438232	690751	142	41265											
SEL1L2	80343	broad.mit.edu	37	chr20	13839936	13839936	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctaagccgtgttcatacAtataagccagattgaacatg	13	11	8	9	1	1	2	1	1	0	1	1	2	1	2	3	0	5	1	3	0	5	6			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr20:13839936A>T	uc010gcf.2	-	18	1872	c.1790T>A	c.(1789-1791)ATG>AAG	p.M597K	SEL1L2_uc002woq.3_Missense_Mutation_p.M458K|SEL1L2_uc010zrl.1_Intron|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	597	Extracellular (Potential).|Sel1-like 11.					integral to membrane	binding			ovary(2)	2						GTGTTCATACATATAAGCCAG	0.413													8	31					0	0	0	0	T	13839936	T	T	13839936	3	4	224	1	0	0	0	0	1	0	0	0	14076	217	8	5	288	5	SEL1L2	20	13839936	Missense_Mutation	SNP	A	TCGA-CV-7102-01A-11D-2012-08		13839936	49185584	143	41266											
C21orf63	59271	broad.mit.edu	37	chr21	33876236	33876236	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgcatttttcatgaaacagGtataaacttcgacccaagcg	13	12	7	9	2	1	1	1	1	0	0	2	2	1	1	1	1	4	2	1	1	5	6			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr21:33876236G>A	uc002ypr.1	+	7	1270	c.860G>A	c.(859-861)GGT>GAT	p.G287D	C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Missense_Mutation_p.G284D|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Missense_Mutation_p.G192D|C21orf63_uc011adq.1_5'UTR	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	287	Extracellular (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3						CATGAAACAGGTATAAACTTC	0.458													38	92					0	0	0	0	A	33876236	A	A	33876236	3	1	224	1	0	0	0	0	1	0	0	0	2141	1275	44	4	886	4	C21orf63	21	33876236	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08		33876236	14253659	144	41267											
U2AF1	7307	broad.mit.edu	37	chr21	44521518	44521518	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcactgttttggggattacGatagatgttttgaatcaaga	11	15	11	4	1	1	3	1	1	0	2	1	5	1	4	0	2	2	3	0	2	4	6			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr21:44521518G>A	uc002zda.1	-	3	241	c.157C>T	c.(157-159)CGT>TGT	p.R53C	U2AF1_uc002zcy.1_Intron|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Intron|U2AF1_uc010gpi.1_Intron|U2AF1_uc002zdc.1_Missense_Mutation_p.R53C	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	53					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						TGGGGATTACGATAGATGTTT	0.398													79	314					0	0	0	0	A	44521518	A	A	44521518	3	1	224	1	0	0	0	0	1	0	0	0	16889	1058	37	1	660	1	U2AF1	21	44521518	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	10645282	44521518	3608377	145	41268											
AIRE	326	broad.mit.edu	37	chr21	45709685	45709685	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcccagggcgctgccccCgtaagcacctgaccttccct	6	6	11	18	2	0	1	0	1	0	0	1	2	1	2	6	2	3	3	6	2	1	2	rs41277550	byFrequency	TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr21:45709685C>T	uc002zei.2	+	6	925	c.798C>T	c.(796-798)CCC>CCT	p.P266P	AIRE_uc010gpq.2_5'Flank|AIRE_uc002zej.2_5'Flank|AIRE_uc010gpr.2_5'Flank	NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	266	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		GCGCTGCCCCCGTAAGCACCT	0.682									Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				18	34					0	0	0	0	T	45709685	T	T	45709685	2	4	224	1	0	0	0	0	0	0	0	1	437	666	23	1		1	AIRE	21	45709685	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	1188167	45709685	2420210	146	41269											
KLHL22	84861	broad.mit.edu	37	chr22	20800823	20800823	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccatgccgtgccaggcgcgCcgcacaggcccatcagccag	7	3	13	18	4	1	0	1	0	0	0	1	0	1	0	6	2	3	1	6	2	0	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr22:20800823C>T	uc002zsl.1	-	6	1555	c.1446G>A	c.(1444-1446)CGG>CGA	p.R482R	KLHL22_uc011ahr.1_Silent_p.R339R	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	482	Kelch 4.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCCAGGCGCGCCGCACAGGCC	0.602													19	93					0	0	0	0	T	20800823	T	T	20800823	2	4	224	1	0	0	0	0	0	0	0	1	8416	726	26	4		4	KLHL22	22	20800823	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08		20800823	30503743	147	41270											
APOBEC3D	140564	broad.mit.edu	37	chr22	39421243	39421243	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctgagcaccccaatgtcAccctgaccatctctgccgcc	7	8	8	18	1	2	2	1	2	1	0	3	2	2	2	6	1	2	2	6	1	1	0			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr22:39421243A>C	uc011aoe.1	+	3	433	c.379A>C	c.(379-381)ACC>CCC	p.T127P	APOBEC3D_uc011aod.1_Missense_Mutation_p.T127P|APOBEC3D_uc011aof.1_Intron|APOBEC3D_uc003awu.3_Intron|APOBEC3D_uc003awt.3_Missense_Mutation_p.T127P|APOBEC3D_uc010gxu.2_Intron	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	127					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					CCCCAATGTCACCCTGACCAT	0.572													13	80					0	0	0	0	C	39421243	C	C	39421243	3	2	224	1	0	0	0	0	1	0	0	0	792	159	6	5	389	5	APOBEC3D	22	39421243	Missense_Mutation	SNP	A	TCGA-CV-7102-01A-11D-2012-08	18620420	39421243	11883323	148	41271											
CSDC2	27254	broad.mit.edu	37	chr22	41969737	41969737	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcacagggccatggcttcatCacccccgagaacgggtccga	9	6	11	15	3	3	1	3	0	0	1	4	3	4	1	4	3	1	1	4	3	1	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chr22:41969737C>T	uc003bak.1	+	3	552	c.255C>T	c.(253-255)ATC>ATT	p.I85I		NM_014460	NP_055275	Q9Y534	CSDC2_HUMAN	RNA-binding protein pippin	85	CSD.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|RNA binding				0						ATGGCTTCATCACCCCCGAGA	0.607													11	84					0	0	0	0	T	41969737	T	T	41969737	2	4	224	1	0	0	0	0	0	0	0	1	3945	816	29	2		2	CSDC2	22	41969737	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	2548494	41969737	9334829	149	41272											
RAI2	10742	broad.mit.edu	37	chrX	17819548	17819549	+	Missense_Mutation	DNP	GG	TT	TT																															tgggggcccgagagtgccctGggagggaaacaaattctgga																										TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:17819548_17819549GG>TT	uc004cyf.2	-	3	1152_1153	c.582_583CC>AA	c.(580-585)TCCCAG>TCAAAG	p.Q195K	RAI2_uc004cyg.2_Missense_Mutation_p.Q195K|RAI2_uc010nfa.2_Missense_Mutation_p.Q195K|RAI2_uc004cyh.3_Missense_Mutation_p.Q195K|RAI2_uc011miy.1_Missense_Mutation_p.Q145K	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	195					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					AGAGTGCCCTGGGAGGGAAACA	0.658													9	42					0	0	0	0	TT	17819549	TT	TT	17819548	3	4	224	1	0	0	0	0	1	0	0	0	13074	1357	47	4	1013	4	RAI2	23	17819548	Missense_Mutation	DNP	GG	TCGA-CV-7102-01A-11D-2012-08		17819548	137451012	150	41273											
CXorf23	256643	broad.mit.edu	37	chrX	19983783	19983783	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacgtctttaggtctttttGatgtgtgtccatattttctg	5	20	8	8	1	3	1	0	1	3	0	4	1	4	1	2	1	0	0	2	1	2	7			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:19983783G>C	uc004czp.2	-	3	653	c.653C>G	c.(652-654)TCA>TGA	p.S218*	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_Translation_Start_Site|CXorf23_uc004czo.2_Nonsense_Mutation_p.S168*	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	218						mitochondrion				lung(1)|skin(1)	2						AGGTCTTTTTGATGTGTGTCC	0.438													22	101					0	0	0	0	C	19983783	C	C	19983783	4	2	224	1	0	0	0	0	0	1	0	0	4120	1294	45	2	1431	2	CXorf23	23	19983783	Nonsense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	2164235	19983783	135286777	151	41274											
DMD	1756	broad.mit.edu	37	chrX	31947740	31947740	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactggagatttgtctgcttGagcttattttcaagtttatc	8	18	8	7	0	2	2	1	1	1	1	3	3	2	2	0	1	2	3	0	1	3	7			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:31947740G>C	uc004dda.1	-	47	7129	c.6885C>G	c.(6883-6885)CTC>CTG	p.L2295L	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Silent_p.L951L|DMD_uc004dcx.2_Silent_p.L954L|DMD_uc004dcz.2_Silent_p.L2172L|DMD_uc004dcy.1_Silent_p.L2291L|DMD_uc004ddb.1_Silent_p.L2287L|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2295	Spectrin 16.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTGTCTGCTTGAGCTTATTTT	0.403													16	84					0	0	0	0	C	31947740	C	C	31947740	2	2	224	1	0	0	0	0	0	0	0	1	4602	1277	45	2		2	DMD	23	31947740	Silent	SNP	G	TCGA-CV-7102-01A-11D-2012-08	11963957	31947740	123322820	152	41275											
MAGEH1	28986	broad.mit.edu	37	chrX	55479236	55479236	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagaagagtttgtgcgcagAgggtacctgatttataaacc	13	10	11	7	1	0	4	0	1	0	3	0	4	0	4	2	1	3	3	2	1	5	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:55479236A>G	uc004dum.2	+	1	699	c.429A>G	c.(427-429)AGA>AGG	p.R143R		NM_014061	NP_054780	Q9H213	MAGH1_HUMAN	melanoma antigen, family H, 1 protein	143	MAGE.				apoptosis					ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TTGTGCGCAGAGGGTACCTGA	0.532													18	60					0	0	0	0	G	55479236	G	G	55479236	2	3	224	1	0	0	0	0	0	0	0	1	9241	301	11	5		5	MAGEH1	23	55479236	Silent	SNP	A	TCGA-CV-7102-01A-11D-2012-08	23531496	55479236	99791324	153	41276											
MED12	9968	broad.mit.edu	37	chrX	70347742	70347742	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctttcctccatccctgcaGcgacttttgctcaaaggtga	7	13	7	14	1	1	1	1	1	0	0	5	2	5	1	4	1	3	2	4	1	1	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:70347742G>T	uc004dyy.2	+	22	3181	c.2982_splice	c.e22-1	p.S994_splice	MED12_uc011mpq.1_Splice_Site_p.S994_splice|MED12_uc004dyz.2_Splice_Site_p.S994_splice|MED12_uc004dza.2_Splice_Site_p.S841_splice|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12						androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CATCCCTGCAGCGACTTTTGC	0.493													11	24					2.80697e-09	5.78085e-09	1	0	T	70347742	T	T	70347742	5	4	224	1	0	0	0	0	0	0	1	0	9481	985	34	4	3067	4	MED12	23	70347742	Splice_Site	SNP	G	TCGA-CV-7102-01A-11D-2012-08	14868506	70347742	84922818	154	41277											
HDAC8	55869	broad.mit.edu	37	chrX	71681889	71681889	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagaggatagtgttttccCtaggatgaccccggtcaagt	9	11	11	10	1	2	2	2	1	0	1	3	4	3	4	3	3	0	1	3	3	3	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:71681889C>G	uc004eau.2	-	9	1012	c.970G>C	c.(970-972)GGG>CGG	p.G324R	HDAC8_uc011mqe.1_Missense_Mutation_p.G181R|HDAC8_uc011mqf.1_Missense_Mutation_p.G129R|HDAC8_uc011mqg.1_Missense_Mutation_p.G233R	NM_018486	NP_060956	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	324	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding				0	Renal(35;0.156)				Vorinostat(DB02546)	AGTGTTTTCCCTAGGATGACC	0.463													18	101					0	0	0	0	G	71681889	G	G	71681889	3	3	224	1	0	0	0	0	1	0	0	0	7052	681	24	4	175	4	HDAC8	23	71681889	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	1334147	71681889	83588671	155	41278											
XKRX	402415	broad.mit.edu	37	chrX	100183244	100183244	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacatcttcctccagagatGaaaccggatccacatttggc	11	10	8	12	1	1	3	0	2	1	1	4	5	4	4	4	2	1	0	4	2	1	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:100183244G>A	uc004egn.2	-	1	655	c.50C>T	c.(49-51)TCA>TTA	p.S17L	XKRX_uc011mre.1_5'UTR	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	17						integral to membrane|plasma membrane				breast(1)	1						CTCCAGAGATGAAACCGGATC	0.468													67	182					0	0	0	0	A	100183244	A	A	100183244	3	1	224	1	0	0	0	0	1	0	0	0	17507	1294	45	2	1311	2	XKRX	23	100183244	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	28501355	100183244	55087316	156	41279											
H2BFWT	158983	broad.mit.edu	37	chrX	103267977	103267977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacctgcttcagcacccggcGgaaataggtggcgaagctgt	10	7	13	11	3	1	0	1	0	0	0	1	2	1	1	2	4	4	3	2	4	4	2			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:103267977G>A	uc004elr.2	-	1	280	c.256C>T	c.(256-258)CGC>TGC	p.R86C		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	86					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						AGCACCCGGCGGAAATAGGTG	0.622													11	102					0	0	0	0	A	103267977	A	A	103267977	3	1	224	1	0	0	0	0	1	0	0	0	6971	1116	39	1	279	1	H2BFWT	23	103267977	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	3084733	103267977	52002583	157	41280											
KIAA1210	57481	broad.mit.edu	37	chrX	118220797	118220797	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacatcatcctgattggataGgtttgcatgctggttattat	10	16	9	6	0	1	1	1	1	0	0	2	2	2	2	1	3	3	4	1	3	4	5			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:118220797G>T	uc004era.3	-	11	4396	c.4396C>A	c.(4396-4398)CTA>ATA	p.L1466I		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1466										ovary(4)|skin(1)	5						TGATTGGATAGGTTTGCATGC	0.433													11	80					6.42651e-13	1.35953e-12	1	0	T	118220797	T	T	118220797	3	4	224	1	0	0	0	0	1	0	0	0	8253	991	35	4	749	4	KIAA1210	23	118220797	Missense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	14952820	118220797	37049763	158	41281											
ENOX2	10495	broad.mit.edu	37	chrX	129799651	129799651	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accacacgctgatgttcttcCgctgggcttttgtgaagtgg	6	13	12	10	2	1	2	0	2	1	0	2	2	2	2	2	2	0	4	2	2	1	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:129799651C>T	uc004evw.2	-	10	1485	c.1067G>A	c.(1066-1068)CGG>CAG	p.R356Q	ENOX2_uc004evx.2_Missense_Mutation_p.R327Q|ENOX2_uc004evy.2_Missense_Mutation_p.R327Q|ENOX2_uc004evv.2_Missense_Mutation_p.R183Q	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	356					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						GATGTTCTTCCGCTGGGCTTT	0.483													4	22					0	0	0	0	T	129799651	T	T	129799651	3	4	224	1	0	0	0	0	1	0	0	0	5151	652	23	1	793	1	ENOX2	23	129799651	Missense_Mutation	SNP	C	TCGA-CV-7102-01A-11D-2012-08	11578854	129799651	25470909	159	41282											
OR13H1	347468	broad.mit.edu	37	chrX	130678614	130678614	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcattaagctgacctgttcTgataccagcctcaatgaatt	11	13	6	11	0	3	3	2	3	1	0	3	3	3	3	3	0	3	2	3	0	4	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:130678614T>G	uc011muw.1	+	1	567	c.567T>G	c.(565-567)TCT>TCG	p.S189S	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					TGACCTGTTCTGATACCAGCC	0.463													49	246					0	0	0	0	G	130678614	G	G	130678614	2	3	224	1	0	0	0	0	0	0	0	1	10997	1567	55	5		5	OR13H1	23	130678614	Silent	SNP	T	TCGA-CV-7102-01A-11D-2012-08	878963	130678614	24591946	160	41283											
GPR112	139378	broad.mit.edu	37	chrX	135431895	135431895	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacccattctgacatggctCttatctagtctcccttctgg	6	15	6	14	0	6	1	1	1	5	0	7	1	6	1	2	2	0	1	2	2	2	4			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:135431895C>G	uc004ezu.1	+	6	6321	c.6030C>G	c.(6028-6030)CTC>CTG	p.L2010L	GPR112_uc010nsb.1_Silent_p.L1805L|GPR112_uc010nsc.1_Silent_p.L1777L	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2010	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TGACATGGCTCTTATCTAGTC	0.453													19	138					0	0	0	0	G	135431895	G	G	135431895	2	3	224	1	0	0	0	0	0	0	0	1	6667	900	32	2		2	GPR112	23	135431895	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	4753281	135431895	19838665	161	41284											
ZIC3	7547	broad.mit.edu	37	chrX	136649666	136649666	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagagctgcgaccggaccttCagcaccatgcatgagctggt	10	7	12	12	2	1	2	1	1	0	1	1	4	1	3	3	2	5	4	3	2	1	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:136649666C>T	uc004fak.2	+	1	1321	c.816C>T	c.(814-816)TTC>TTT	p.F272F		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	272	C2H2-type 1; atypical.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					ACCGGACCTTCAGCACCATGC	0.612													9	94					0	0	0	0	T	136649666	T	T	136649666	2	4	224	1	0	0	0	0	0	0	0	1	17747	825	29	2		2	ZIC3	23	136649666	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	1217771	136649666	18620894	162	41285											
UBE2NL	389898	broad.mit.edu	37	chrX	142967283	142967283	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggcatcaaagcagaaccAgatgaaagcaacgcccgtta	15	5	9	12	2	1	3	1	1	0	2	1	3	1	3	3	1	4	4	3	1	5	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:142967283A>G	uc004fca.2	+	1	111	c.81A>G	c.(79-81)CCA>CCG	p.P27P		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	27							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCAGAACCAGATGAAAGCA	0.512													44	111					0	0	0	0	G	142967283	G	G	142967283	2	3	224	1	0	0	0	0	0	0	0	1	16935	175	7	5		5	UBE2NL	23	142967283	Silent	SNP	A	TCGA-CV-7102-01A-11D-2012-08	6317617	142967283	12303277	163	41286											
CD99L2	83692	broad.mit.edu	37	chrX	149963727	149963727	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccatcatctcgatcatttcGatcatccagggcatcagcca	10	10	7	14	2	5	0	4	0	1	0	8	2	6	0	3	1	1	1	3	1	0	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:149963727G>A	uc004fel.2	-	6	500	c.382C>T	c.(382-384)CGA>TGA	p.R128*	CD99L2_uc004fek.2_RNA|CD99L2_uc004fem.2_Nonsense_Mutation_p.R79*|CD99L2_uc004fen.2_Nonsense_Mutation_p.R56*|CD99L2_uc004feo.2_RNA|CD99L2_uc011myb.1_Intron	NM_031462	NP_113650	Q8TCZ2	C99L2_HUMAN	CD99 antigen-like 2 isoform E3'-E4'-E3-E4	128	Extracellular (Potential).			R -> Q (in Ref. 4; BAG54124).	cell adhesion	cell junction|integral to membrane				large_intestine(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CGATCATTTCGATCATCCAGG	0.448													32	205					0	0	0	0	A	149963727	A	A	149963727	4	1	224	1	0	0	0	0	0	1	0	0	3066	1066	37	1	430	1	CD99L2	23	149963727	Nonsense_Mutation	SNP	G	TCGA-CV-7102-01A-11D-2012-08	6996444	149963727	5306833	164	41287											
MAGEA3	4102	broad.mit.edu	37	chrX	151935346	151935346	+	Frame_Shift_Del	DEL	C	-	-																															tttcaacgagggcccttggaCcccacaggaattcataacat																										TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:151935346delC	uc004fgp.2	-	3	1030	c.821delG	c.(820-822)GGTfs	p.G274fs		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	274	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCCTTGGACCCCACAGGAA	0.532													---	---	---								-	151935346	-	-	151935346	7	5	224	1	0	1	0	1	0	0	0	0	9218	507	18	0	127	0	MAGEA3	23	151935346	Frame_Shift_Del	DEL	C	TCGA-CV-7102-01A-11D-2012-08	1971619	151935346	3335214	165	41288											
FAM3A	60343	broad.mit.edu	37	chrX	153736911	153736911	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctggggcaggccacacttgtActtcctggcccgtggcgctg	4	9	14	14	2	0	0	0	0	0	0	1	0	1	0	3	5	1	3	3	5	1	3			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:153736911A>T	uc004fls.1	-	4	446	c.169T>A	c.(169-171)TAC>AAC	p.Y57N	FAM3A_uc004flt.1_Missense_Mutation_p.Y71N|FAM3A_uc011mzp.1_Missense_Mutation_p.Y57N|FAM3A_uc004flu.1_Missense_Mutation_p.Y71N|FAM3A_uc011mzq.1_Missense_Mutation_p.Y57N|FAM3A_uc004flw.1_Missense_Mutation_p.Y57N	NM_021806	NP_068578	P98173	FAM3A_HUMAN	family 3, member A protein precursor	57						extracellular region				large_intestine(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCACACTTGTACTTCCTGGCC	0.647													6	11					0	0	0	0	T	153736911	T	T	153736911	3	4	224	1	0	0	0	0	1	0	0	0	5588	391	14	5	547	5	FAM3A	23	153736911	Missense_Mutation	SNP	A	TCGA-CV-7102-01A-11D-2012-08	1801565	153736911	1533649	166	41289											
MPP1	4354	broad.mit.edu	37	chrX	154033634	154033634	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccccactctcgccctcgctCgccttgagggtcatctcgca	4	9	8	20	4	3	1	1	1	2	0	7	1	3	1	4	1	0	2	4	1	0	1			TCGA-CV-7102-01A-11D-2012-08	TCGA-CV-7102-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	eda5514f-3aa1-447c-ad07-55ec307c26e3	ef91ddf9-e769-44cd-9991-37dae71bc012	g.chrX:154033634C>T	uc004fmp.1	-	1	130	c.15G>A	c.(13-15)GCG>GCA	p.A5A	MPP1_uc010nvg.1_Silent_p.A5A|MPP1_uc011mzv.1_5'UTR|MPP1_uc004fmq.1_5'UTR|MPP1_uc011mzw.1_Silent_p.A5A|MPP1_uc010nvh.1_Silent_p.A5A	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	5					regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGCCCTCGCTCGCCTTGAGGG	0.672													4	25					0	0	0	0	T	154033634	T	T	154033634	2	4	224	1	0	0	0	0	0	0	0	1	9786	871	31	1		1	MPP1	23	154033634	Silent	SNP	C	TCGA-CV-7102-01A-11D-2012-08	296723	154033634	1236926	167	41290											
CASZ1	54897	broad.mit.edu	37	chr1	10714479	10714479	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accaggctcccgcttacctgCagtggaagtgcgtggtcttc	6	10	12	13	2	1	0	0	0	1	0	3	1	2	1	3	3	3	3	3	3	2	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr1:10714479C>T	uc001aro.2	-	10	2155	c.1835G>A	c.(1834-1836)TGC>TAC	p.C612Y	CASZ1_uc001arp.1_Missense_Mutation_p.C612Y|CASZ1_uc009vmx.2_Missense_Mutation_p.C636Y	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	612	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CGCTTACCTGCAGTGGAAGTG	0.652													24	51					0	0	0	0	T	10714479	T	T	10714479	3	4	225	1	0	0	0	0	1	0	0	0	2697	710	25	4	3496	4	CASZ1	1	10714479	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08		10714479	238536142	1	41291											
LOC440563	440563	broad.mit.edu	37	chr1	13183372	13183373	+	Missense_Mutation	DNP	CC	AA	AA																															tttccagacttggaagatccCcgctttccactcttagaatt																										TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr1:13183372_13183373CC>AA	uc010obg.1	-	1	595_596	c.500_501GG>TT	c.(499-501)CGG>CTT	p.R167L		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	167						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						TGGAAGATCCCCGCTTTCCACT	0.495													17	813					0	0	0	0	AA	13183373	AA	AA	13183372	3	1	225	1	0	0	0	0	1	0	0	0	8928	610	22	4	384	4	LOC440563	1	13183372	Missense_Mutation	DNP	CC	TCGA-CV-7103-01A-21D-2012-08	2468893	13183372	236067249	2	41292											
RAD54L	8438	broad.mit.edu	37	chr1	46726555	46726556	+	Frame_Shift_Ins	INS	-	AC	AC																															agagtgcaagccagaaattgINSacaaggcagtggtggtgtcg																										TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr1:46726555_46726556insAC	uc009vye.2	+	8	748_749	c.634_635insAC	c.(634-636)GACfs	p.D212fs	RAD54L_uc001cpl.2_Frame_Shift_Ins_p.D212fs|RAD54L_uc001cpm.1_Frame_Shift_Ins_p.D32fs	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	212	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		GCCAGAAATTGACAAGGCAGTG	0.535								Direct_reversal_of_damage|Homologous_recombination					---	---	---								AC	46726556	AC	AC	46726555	7	5	225	1	0	1	1	0	0	0	0	0	13058	1290	45	0	660	0	RAD54L	1	46726555	Frame_Shift_Ins	INS	-	TCGA-CV-7103-01A-21D-2012-08	33543183	46726555	202524066	3	41293											
SERBP1	26135	broad.mit.edu	37	chr1	67895933	67895933	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcgtcgtcaaataactggtcGaatcggttggtgaccacgca	10	10	11	10	5	1	1	1	1	0	0	5	2	1	1	1	3	1	2	1	3	3	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr1:67895933G>C	uc001ddv.2	-	1	191	c.51C>G	c.(49-51)TTC>TTG	p.F17L	SERBP1_uc001ddx.2_Missense_Mutation_p.F17L|SERBP1_uc001ddy.2_Missense_Mutation_p.F17L|SERBP1_uc001ddw.2_Missense_Mutation_p.F17L	NM_001018067	NP_001018077	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1 isoform 1	17					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			skin(1)	1						ATAACTGGTCGAATCGGTTGG	0.642													51	42					0	0	0	0	C	67895933	C	C	67895933	3	2	225	1	0	0	0	0	1	0	0	0	14140	1049	37	3	1207	3	SERBP1	1	67895933	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08	21169378	67895933	181354688	4	41294											
PLEKHO1	51177	broad.mit.edu	37	chr1	150129105	150129105	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caggaatcttcccctcacagGcacccaacctgatcttcctg	9	9	6	17	0	3	1	1	1	2	0	5	2	5	2	5	2	1	1	5	2	2	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr1:150129105G>T	uc001ett.2	+	4	597	c.319G>T	c.(319-321)GCA>TCA	p.A107S	PLEKHO1_uc001etr.2_5'UTR|PLEKHO1_uc001ets.2_5'UTR|PLEKHO1_uc001etu.2_5'UTR	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	107	PH.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCCCTCACAGGCACCCAACCT	0.478													10	64					3.07112e-06	3.97684e-05	1	0	T	150129105	T	T	150129105	3	4	225	1	0	0	0	0	1	0	0	0	12139	1217	42	4	333	4	PLEKHO1	1	150129105	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08	82233172	150129105	99121516	5	41295											
PRKD3	23683	broad.mit.edu	37	chr2	37505102	37505102	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgatggattgtacaaccctCattagcggaatattattgct	11	15	8	7	1	1	1	1	1	0	0	1	3	1	3	1	2	4	2	1	2	6	7			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr2:37505102C>T	uc002rqd.2	-	8	1758	c.1203G>A	c.(1201-1203)ATG>ATA	p.M401I	PRKD3_uc002rqe.1_Missense_Mutation_p.M1I|PRKD3_uc002rqf.1_Missense_Mutation_p.M401I	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	401					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				GTACAACCCTCATTAGCGGAA	0.363													15	99					0	0	0	0	T	37505102	T	T	37505102	3	4	225	1	0	0	0	0	1	0	0	0	12582	826	29	2	1513	2	PRKD3	2	37505102	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08		37505102	205694271	6	41296											
NXPH2	11249	broad.mit.edu	37	chr2	139429083	139429083	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgcgtacgccatggggccGggcttgggcaccggagactg	5	7	17	12	4	1	1	0	0	1	1	1	2	1	1	3	5	2	3	3	5	1	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr2:139429083G>A	uc002tvi.2	-	2	204	c.204C>T	c.(202-204)CCC>CCT	p.P68P		NM_007226	NP_009157	O95156	NXPH2_HUMAN	neurexophilin 2 precursor	68	II.				neuropeptide signaling pathway	extracellular region				ovary(3)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(221;0.101)		CCATGGGGCCGGGCTTGGGCA	0.552													52	107					0	0	0	0	A	139429083	A	A	139429083	2	1	225	1	0	0	0	0	0	0	0	1	10845	1103	39	1		1	NXPH2	2	139429083	Silent	SNP	G	TCGA-CV-7103-01A-21D-2012-08	101923981	139429083	103770290	7	41297											
IKZF2	22807	broad.mit.edu	37	chr2	213878609	213878609	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaaaaggcaccagagaaatAttgttgtccataataggctc	15	10	8	8	0	1	1	1	0	0	1	3	2	2	1	2	2	0	3	2	2	6	5			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr2:213878609A>C	uc002vem.2	-	7	931	c.762T>G	c.(760-762)AAT>AAG	p.N254K	IKZF2_uc010fuu.2_Missense_Mutation_p.N109K|IKZF2_uc002vej.2_Missense_Mutation_p.N201K|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Intron|IKZF2_uc002vel.2_Missense_Mutation_p.N175K|IKZF2_uc010fuw.2_Missense_Mutation_p.N28K|IKZF2_uc010fux.2_Missense_Mutation_p.N28K|IKZF2_uc010fuy.2_Missense_Mutation_p.N182K|IKZF2_uc002ven.2_Missense_Mutation_p.N228K|IKZF2_uc002vei.2_Missense_Mutation_p.N32K	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CCAGAGAAATATTGTTGTCCA	0.393													12	61					0	0	0	0	C	213878609	C	C	213878609	3	2	225	1	0	0	0	0	1	0	0	0	7654	446	16	5	826	5	IKZF2	2	213878609	Missense_Mutation	SNP	A	TCGA-CV-7103-01A-21D-2012-08	74449526	213878609	29320764	8	41298											
DIRC2	84925	broad.mit.edu	37	chr3	122598138	122598139	+	Missense_Mutation	DNP	CG	AT	AT																															tggttcaactggtgccttccCgggtcgtgtttgctcagtct																										TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:122598138_122598139CG>AT	uc003efw.3	+	9	1489_1490	c.1350_1351CG>AT	c.(1348-1353)CCCGGG>CCATGG	p.G451W	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Missense_Mutation_p.G289W|uc003efx.1_RNA	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	451	Helical; (Potential).				transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		GGTGCCTTCCCGGGTCGTGTTT	0.455													11	675					0	0	0	0	AT	122598139	AT	AT	122598138	3	1	225	1	0	0	0	0	1	0	0	0	4556	639	23	3	1384	3	DIRC2	3	122598138	Missense_Mutation	DNP	CG	TCGA-CV-7103-01A-21D-2012-08		122598138	75424292	9	41299											
ATR	545	broad.mit.edu	37	chr3	142176456	142176456	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggtgattacctcattaaagGctctcgctgatcacgcatca	11	11	8	11	2	4	2	3	2	1	0	5	2	4	2	1	2	1	3	1	2	3	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:142176456G>T	uc003eux.3	-	45	7767	c.7645C>A	c.(7645-7647)CCT>ACT	p.P2549T	ATR_uc003euy.1_Missense_Mutation_p.P435T	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2549	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CTCATTAAAGGCTCTCGCTGA	0.373								Other_conserved_DNA_damage_response_genes					40	38					1.22674e-20	1.70406e-19	1	0	T	142176456	T	T	142176456	3	4	225	1	0	0	0	0	1	0	0	0	1206	1203	42	4	301	4	ATR	3	142176456	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08	19578318	142176456	55845974	10	41300											
B3GNT5	84002	broad.mit.edu	37	chr3	182987673	182987674	+	Frame_Shift_Ins	INS	-	T	T																															gttttttagcgagcctcatgINStttttttgggaaccaatcga																										TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	781ad94b-11bb-408a-879a-5ce9defc3d2a	g.chr3:182987673_182987674insT	uc003flk.2	+	2	617_618	c.87_88insT	c.(85-90)ATGTTTfs	p.M29fs	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Frame_Shift_Ins_p.M29fs|B3GNT5_uc003flm.2_Frame_Shift_Ins_p.M29fs	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	29_30	Helical; Signal-anchor for type II membrane protein; (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CGAGCCTCATGTTTTTTTGGGA	0.356													---	---	---								T	182987674	T	T	182987673	7	5	225	1	0	1	1	0	0	0	0	0	1262	1377	48	0	89	0	B3GNT5	3	182987673	Frame_Shift_Ins	INS	-	TCGA-CV-7103-01A-21D-2012-08	40811217	182987673	15034757	11	41301											
ALG3	10195	broad.mit.edu	37	chr3	183960340	183960340	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgttgggtgctcttggggaAaggctgcgggcccagccaga	6	8	18	9	1	1	1	0	0	1	1	1	2	1	2	2	5	3	3	2	5	1	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:183960340A>G	uc003fne.2	-	9	1310	c.1279T>C	c.(1279-1281)TTC>CTC	p.F427L	ALG3_uc011brc.1_Missense_Mutation_p.F392L|ALG3_uc011brd.1_Missense_Mutation_p.F371L|ALG3_uc011bre.1_Missense_Mutation_p.F379L	NM_005787	NP_005778	Q92685	ALG3_HUMAN	alpha-1,3-mannosyltransferase ALG3 isoform a	427	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity				0	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTCTTGGGGAAAGGCTGCGGG	0.597													44	154					0	0	0	0	G	183960340	G	G	183960340	3	3	225	1	0	0	0	0	1	0	0	0	520	14	1	5	41	5	ALG3	3	183960340	Missense_Mutation	SNP	A	TCGA-CV-7103-01A-21D-2012-08	972667	183960340	14062090	12	41302											
TMEM41A	90407	broad.mit.edu	37	chr3	185212517	185212518	+	Frame_Shift_Ins	INS	-	A	A																															aaagtctcaaaaacaataagINSaaaaaaaacaagctgtttct																								rs150885877	byFrequency	TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:185212517_185212518insA	uc003fpj.2	-	4	563_564	c.467_468insT	c.(466-468)TTCfs	p.F156fs	TMEM41A_uc003fpk.2_Intron|TMEM41A_uc003fpl.2_3'UTR	NM_080652	NP_542383	Q96HV5	TM41A_HUMAN	transmembrane protein 41A precursor	156	Helical; (Potential).					integral to membrane					0	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAAACAATAAGAAAAAAAACAA	0.396													---	---	---								A	185212518	A	A	185212517	7	5	225	1	0	1	1	0	0	0	0	0	16230	933	33	0	334	0	TMEM41A	3	185212517	Frame_Shift_Ins	INS	-	TCGA-CV-7103-01A-21D-2012-08	1252177	185212517	12809913	13	41303											
IGF2BP2	10644	broad.mit.edu	37	chr3	185363333	185363333	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcctcacttgctgcgctGtgaggcgactccctgagggt	5	9	15	12	2	1	2	1	2	0	0	2	4	2	3	2	3	3	2	2	3	0	1			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr3:185363333G>A	uc003fpo.2	-	16	1865	c.1786C>T	c.(1786-1788)CAG>TAG	p.Q596*	IGF2BP2_uc010hyi.2_Nonsense_Mutation_p.Q539*|IGF2BP2_uc010hyj.2_Nonsense_Mutation_p.Q533*|IGF2BP2_uc010hyk.2_Nonsense_Mutation_p.Q460*|IGF2BP2_uc010hyl.2_Nonsense_Mutation_p.Q490*|IGF2BP2_uc003fpp.2_Nonsense_Mutation_p.Q553*|IGF2BP2_uc003fpq.2_Nonsense_Mutation_p.Q601*	NM_006548	NP_006539	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding	596					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity				0	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TTGCTGCGCTGTGAGGCGACT	0.547													100	46					0	0	0	0	A	185363333	A	A	185363333	4	1	225	1	0	0	0	0	0	1	0	0	7613	1386	48	4	17	4	IGF2BP2	3	185363333	Nonsense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08	150816	185363333	12659097	14	41304											
PCGF3	10336	broad.mit.edu	37	chr4	755159	755159	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggcgaccgtcttgcatctGaagaagttcatcgccaaaaa	13	8	9	11	3	3	2	1	1	2	1	4	3	3	2	2	1	1	2	2	1	4	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr4:755159G>A	uc011bva.1	+	10	1030	c.555G>A	c.(553-555)CTG>CTA	p.L185L	PCGF3_uc003gbd.1_RNA|PCGF3_uc003gbe.2_Silent_p.L185L|PCGF3_uc010ibh.2_Silent_p.L185L|PCGF3_uc003gbg.1_Silent_p.L151L|PCGF3_uc003gbh.2_Silent_p.L151L	NM_006315	NP_006306	Q3KNV8	PCGF3_HUMAN	ring finger protein 3	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	zinc ion binding				0						TCTTGCATCTGAAGAAGTTCA	0.498													6	67					0	0	0	0	A	755159	A	A	755159	2	1	225	1	0	0	0	0	0	0	0	1	11630	1277	45	2		2	PCGF3	4	755159	Silent	SNP	G	TCGA-CV-7103-01A-21D-2012-08		755159	190399117	15	41305											
GABRA2	2555	broad.mit.edu	37	chr4	46388201	46388201	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcttggatgttagccagcAccaacctaaacagataattt	13	12	6	10	0	1	1	0	0	1	1	1	2	1	2	3	1	4	2	3	1	5	6			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr4:46388201A>G	uc003gxc.3	-	2	750	c.77T>C	c.(76-78)GTG>GCG	p.V26A	GABRA2_uc010igc.2_Missense_Mutation_p.V26A|GABRA2_uc011bzc.1_5'UTR|GABRA2_uc003gxe.2_Missense_Mutation_p.V26A|GABRA2_uc010igd.1_Missense_Mutation_p.V26A	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	26					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTTAGCCAGCACCAACCTAAA	0.343													9	18					0	0	0	0	G	46388201	G	G	46388201	3	3	225	1	0	0	0	0	1	0	0	0	6195	159	6	5	1310	5	GABRA2	4	46388201	Missense_Mutation	SNP	A	TCGA-CV-7103-01A-21D-2012-08	45633042	46388201	144766075	16	41306											
POLR2B	5431	broad.mit.edu	37	chr4	57896547	57896547	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catacatatgaatgcaggggCtgccgcaataaaacccaggt	14	7	10	10	1	0	1	0	1	0	0	0	1	0	1	2	3	4	3	2	3	6	3			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr4:57896547C>T	uc003hcl.1	+	24	3460	c.3417C>T	c.(3415-3417)GGC>GGT	p.G1139G	POLR2B_uc011cae.1_Silent_p.G1132G|POLR2B_uc011caf.1_Silent_p.G1064G|POLR2B_uc003hcm.1_Silent_p.G632G	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	1139	C4-type.				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					AATGCAGGGGCTGCCGCAATA	0.433													17	20					0	0	0	0	T	57896547	T	T	57896547	2	4	225	1	0	0	0	0	0	0	0	1	12270	784	28	4		4	POLR2B	4	57896547	Silent	SNP	C	TCGA-CV-7103-01A-21D-2012-08	11508346	57896547	133257729	17	41307											
ETFDH	2110	broad.mit.edu	37	chr4	159620266	159620266	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atacggagccagagctctcaAtgaaggtggctttcaggtaa	12	9	12	8	1	2	2	2	1	1	1	3	3	2	3	1	4	3	3	1	4	4	3			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr4:159620266A>G	uc003iqb.2	+	9	1432	c.1100A>G	c.(1099-1101)AAT>AGT	p.N367S	ETFDH_uc011cjg.1_Missense_Mutation_p.N320S|ETFDH_uc010iqr.2_Intron|ETFDH_uc011cjh.1_Missense_Mutation_p.N306S|ETFDH_uc010iqs.2_Missense_Mutation_p.N289S	NM_004453	NP_004444	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	367					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			large_intestine(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		AGAGCTCTCAATGAAGGTGGC	0.378													16	14					0	0	0	0	G	159620266	G	G	159620266	3	3	225	1	0	0	0	0	1	0	0	0	5295	101	4	5	1134	5	ETFDH	4	159620266	Missense_Mutation	SNP	A	TCGA-CV-7103-01A-21D-2012-08	101723719	159620266	31534010	18	41308											
FAT1	2195	broad.mit.edu	37	chr4	187517826	187517826	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggtgcccgtgcacagactCggggttaaaagtgctgaatt	9	10	13	9	3	0	2	0	1	0	1	2	2	0	2	1	3	3	3	1	3	3	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr4:187517826C>A	uc003izf.2	-	25	13056	c.12868G>T	c.(12868-12870)GAG>TAG	p.E4290*	FAT1_uc010isn.2_5'Flank|FAT1_uc003ize.2_Nonsense_Mutation_p.E181*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4290	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGCACAGACTCGGGGTTAAAA	0.557										HNSCC(5;0.00058)			22	12					8.10497e-08	1.06762e-06	1	0	A	187517826	A	A	187517826	4	1	225	1	0	0	0	0	0	1	0	0	5721	893	31	3	910	3	FAT1	4	187517826	Nonsense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08	27897560	187517826	3636450	19	41309											
ANKH	56172	broad.mit.edu	37	chr5	14716943	14716944	+	Frame_Shift_Ins	INS	-	G	G																															ccaaaacatcacgaaacagaINSgctggggagaaagacatcaa																										TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr5:14716943_14716944insG	uc003jfm.3	-	9	1343_1344	c.1012_1013insC	c.(1012-1014)CTCfs	p.L338fs	ANKH_uc003jfl.3_Frame_Shift_Ins_p.L51fs	NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	338	Helical; (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						CACGAAACAGAGCTGGGGAGAA	0.455													---	---	---								G	14716944	G	G	14716943	7	5	225	1	0	1	1	0	0	0	0	0	627	318	11	0	481	0	ANKH	5	14716943	Frame_Shift_Ins	INS	-	TCGA-CV-7103-01A-21D-2012-08		14716943	166198317	20	41310											
EGFLAM	133584	broad.mit.edu	37	chr5	38464067	38464067	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccgtggatgggaaaaacatCaacacttgtggagccaagta	14	7	12	8	1	1	0	1	0	0	0	1	3	1	3	2	3	3	1	2	3	5	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr5:38464067C>G	uc003jlc.1	+	23	3357	c.3033C>G	c.(3031-3033)ATC>ATG	p.I1011M	EGFLAM_uc003jlb.1_Missense_Mutation_p.I1003M|EGFLAM_uc003jle.1_Missense_Mutation_p.I769M|EGFLAM_uc003jlf.1_Missense_Mutation_p.I369M|EGFLAM_uc003jlg.1_Missense_Mutation_p.I146M|EGFLAM_uc003jlh.1_Missense_Mutation_p.I93M	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	1011	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					GGAAAAACATCAACACTTGTG	0.527													7	94					0	0	0	0	G	38464067	G	G	38464067	3	3	225	1	0	0	0	0	1	0	0	0	4988	816	29	2	3109	2	EGFLAM	5	38464067	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08	23747124	38464067	142451193	21	41311											
KIF3A	11127	broad.mit.edu	37	chr5	132037805	132037805	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcccgaggtataaagttatCaataataagcatctgaagtc	16	11	7	7	1	2	1	1	1	1	0	4	2	3	1	1	1	1	3	1	1	8	5			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr5:132037805C>G	uc003kxo.2	-	13	1931	c.1777G>C	c.(1777-1779)GAT>CAT	p.D593H	KIF3A_uc003kxm.2_Missense_Mutation_p.D175H|KIF3A_uc003kxn.2_Missense_Mutation_p.D578H|KIF3A_uc011cxf.1_Missense_Mutation_p.D620H|KIF3A_uc003kxp.2_Missense_Mutation_p.D596H	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	593					blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATAAAGTTATCAATAATAAGC	0.413													26	22					0	0	0	0	G	132037805	G	G	132037805	3	3	225	1	0	0	0	0	1	0	0	0	8339	826	29	2	342	2	KIF3A	5	132037805	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08	93573738	132037805	48877455	22	41312											
BTNL8	79908	broad.mit.edu	37	chr5	180335857	180335857	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggaaaacattactgtgttGgatgctggcctctatgggtg	8	13	13	7	0	1	0	0	0	1	0	1	2	1	2	1	4	3	2	1	4	4	3			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr5:180335857G>T	uc003mmp.2	+	2	555	c.321G>T	c.(319-321)TTG>TTT	p.L107F	BTNL8_uc003mmq.2_Missense_Mutation_p.L107F|BTNL8_uc011dhg.1_Intron|BTNL8_uc010jll.2_Missense_Mutation_p.L107F|BTNL8_uc010jlm.2_Intron|BTNL8_uc011dhh.1_5'Flank	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	107	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTACTGTGTTGGATGCTGGCC	0.473													13	207					1.49906e-05	0.00019088	1	0	T	180335857	T	T	180335857	3	4	225	1	0	0	0	0	1	0	0	0	1572	1339	47	4	353	4	BTNL8	5	180335857	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08	48298052	180335857	579403	23	41313			1	65		2	2	18	G		3.020298e-05
BTNL8	79908	broad.mit.edu	37	chr5	180335874	180335874	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttggatgctggcctctatgGgtgcaggattagttcccagt	6	13	14	8	0	1	0	0	0	1	0	2	2	2	2	2	4	2	4	2	4	2	4			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr5:180335874G>T	uc003mmp.2	+	2	572	c.338G>T	c.(337-339)GGG>GTG	p.G113V	BTNL8_uc003mmq.2_Missense_Mutation_p.G113V|BTNL8_uc011dhg.1_Intron|BTNL8_uc010jll.2_Missense_Mutation_p.G113V|BTNL8_uc010jlm.2_Intron|BTNL8_uc011dhh.1_5'Flank	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	113	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCCTCTATGGGTGCAGGATT	0.478													12	209					0.000151284	0.00189478	1	0	T	180335874	T	T	180335874	3	4	225	1	0	0	0	0	1	0	0	0	1572	1232	43	4	370	4	BTNL8	5	180335874	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08	17	180335874	579386	24	41314			1	65		2	2	18	G		3.020298e-05
PHACTR1	221692	broad.mit.edu	37	chr6	13230292	13230292	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctggccatgaaggtctgcAggaaggactccttagccatc	9	8	11	13	0	1	1	0	1	1	0	3	3	2	3	4	4	2	1	4	4	3	1			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr6:13230292A>C	uc010jpc.2	+	10	1590	c.1258A>C	c.(1258-1260)AGG>CGG	p.R420R	PHACTR1_uc011dir.1_Silent_p.R489R|PHACTR1_uc003nag.1_Silent_p.R420R|PHACTR1_uc003nah.1_Silent_p.R420R	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	420						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GAAGGTCTGCAGGAAGGACTC	0.547													4	6					0	0	0	0	C	13230292	C	C	13230292	2	2	225	1	0	0	0	0	0	0	0	1	11864	179	7	5		5	PHACTR1	6	13230292	Silent	SNP	A	TCGA-CV-7103-01A-21D-2012-08		13230292	157884775	25	41315											
DOPEY1	23033	broad.mit.edu	37	chr6	83866921	83866941	+	In_Frame_Del	DEL	CGTTTGCCACAGGTGCCAACT	-	-																															agagattggttgagagtctcCgtttgccacaggtgccaact																										TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr6:83866921_83866941delCGTTTGCCACAGGTGCCAACT	uc003pjs.1	+	35	6885_6905	c.6625_6645delCGTTTGCCACAGGTGCCAACT	c.(6625-6645)CGTTTGCCACAGGTGCCAACTdel	p.RLPQVPT2209del	DOPEY1_uc011dyy.1_In_Frame_Del_p.RLPQVPT2200del|DOPEY1_uc010kbl.1_In_Frame_Del_p.RLPQVPT2200del|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	2209_2215					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TGAGAGTCTCCGTTTGCCACAGGTGCCAACTCTCCATTCTC	0.371													---	---	---								-	83866941	-	-	83866921	7	5	225	1	0	1	0	1	0	0	0	0	4729	652	23	0	6755	0	DOPEY1	6	83866921	In_Frame_Del	DEL	CGTTTGCCACAGGTGCCAACT	TCGA-CV-7103-01A-21D-2012-08	70636629	83866921	87248146	26	41316											
OGDH	4967	broad.mit.edu	37	chr7	44747333	44747333	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcagccgcgccaagcccgtCtggtaaggcttcagtccctg	7	8	11	15	3	3	0	2	0	1	0	4	0	4	0	4	2	2	2	4	2	2	2	rs1135689		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr7:44747333C>G	uc003tln.2	+	22	3058	c.2949C>G	c.(2947-2949)GTC>GTG	p.V983V	OGDH_uc011kbx.1_Silent_p.V979V|OGDH_uc011kby.1_Silent_p.V833V|OGDH_uc003tlp.2_Silent_p.V994V|OGDH_uc011kbz.1_Silent_p.V778V	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	983					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	CCAAGCCCGTCTGGTAAGGCT	0.612													29	52					0	0	0	0	G	44747333	G	G	44747333	2	3	225	1	0	0	0	0	0	0	0	1	10893	900	32	2		2	OGDH	7	44747333	Silent	SNP	C	TCGA-CV-7103-01A-21D-2012-08		44747333	114391330	27	41317											
EGFR	1956	broad.mit.edu	37	chr7	55210002	55210002	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccaaggcacgagtaacaagCtcacgcagttgggcactttt	11	8	11	11	2	1	0	1	0	0	0	1	1	1	0	1	2	2	6	1	2	3	4			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr7:55210002C>G	uc003tqk.2	+	2	358	c.112C>G	c.(112-114)CTC>GTC	p.L38V	EGFR_uc003tqh.2_Missense_Mutation_p.L38V|EGFR_uc003tqi.2_Missense_Mutation_p.L38V|EGFR_uc003tqj.2_Missense_Mutation_p.L38V|EGFR_uc010kzg.1_Missense_Mutation_p.L38V|EGFR_uc011kco.1_5'UTR	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	38	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GAGTAACAAGCTCACGCAGTT	0.408		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			33	62					0	0	0	0	G	55210002	G	G	55210002	3	3	225	1	0	0	0	0	1	0	0	0	4989	797	28	4	118	4	EGFR	7	55210002	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08	10462669	55210002	103928661	28	41318											
TEX15	56154	broad.mit.edu	37	chr8	30705568	30705568	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccattccaatgctagatgAtctagttcatccttatcctt	9	16	5	11	0	2	2	1	1	1	1	5	2	5	2	4	0	2	2	4	0	4	6			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr8:30705568A>T	uc003xil.2	-	1	966	c.966T>A	c.(964-966)GAT>GAA	p.D322E		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	322										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATGCTAGATGATCTAGTTCAT	0.343													13	29					0	0	0	0	T	30705568	T	T	30705568	3	4	225	1	0	0	0	0	1	0	0	0	15845	330	12	5	7419	5	TEX15	8	30705568	Missense_Mutation	SNP	A	TCGA-CV-7103-01A-21D-2012-08		30705568	115658454	29	41319											
ABO	28	broad.mit.edu	37	chr9	136132874	136132874	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggatgtcgatgttgaatGtgccctcccagacaatggga	10	10	13	8	1	0	3	0	2	0	1	2	6	1	5	2	2	1	1	2	2	2	1			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr9:136132874G>A	uc004cda.1	-	7	321	c.296C>T	c.(295-297)ACA>ATA	p.T99I	ABO_uc010naf.1_5'UTR|ABO_uc011mcz.1_Intron|ABO_uc010nag.1_5'UTR	NM_020469	NP_065202	P16442	BGAT_HUMAN	ABO blood group (alpha	99	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		GATGTTGAATGTGCCCTCCCA	0.557													33	38					0	0	0	0	A	136132874	A	A	136132874	3	1	225	1	0	0	0	0	1	0	0	0	97	1377	48	4	776	4	ABO	9	136132874	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08		136132874	5080557	30	41320											
USP6NL	9712	broad.mit.edu	37	chr10	11505354	11505354	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgcacgtttgacacccgcaCctcggcaggacctgggacgg	7	5	13	16	5	0	1	0	1	0	0	1	3	0	3	4	4	0	4	4	4	0	1			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr10:11505354C>T	uc001ikt.3	-	15	1894	c.1573G>A	c.(1573-1575)GTG>ATG	p.V525M	USP6NL_uc001iks.1_Missense_Mutation_p.V542M	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	525						intracellular	Rab GTPase activator activity				0						GACACCCGCACCTCGGCAGGA	0.622													50	131					0	0	0	0	T	11505354	T	T	11505354	3	4	225	1	0	0	0	0	1	0	0	0	17155	507	18	4	917	4	USP6NL	10	11505354	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08		11505354	124029393	31	41321											
BLNK	29760	broad.mit.edu	37	chr10	97987176	97987176	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggacctcacctatatactcGcctctggcgaagggcagggc	8	7	13	13	2	2	0	1	0	1	0	3	2	2	1	3	4	1	1	3	4	4	3			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr10:97987176G>A	uc001kls.3	-	5	529	c.351C>T	c.(349-351)GGC>GGT	p.G117G	BLNK_uc001kme.3_Silent_p.G35G|BLNK_uc001klt.3_Splice_Site_p.D35_splice|BLNK_uc009xvc.2_Intron|BLNK_uc001klu.3_Silent_p.G35G|BLNK_uc001klv.3_Splice_Site_p.G117_splice|BLNK_uc001klw.3_RNA|BLNK_uc001klx.3_Silent_p.G117G|BLNK_uc001kly.3_Silent_p.G117G|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Silent_p.G117G|BLNK_uc001kmb.3_Splice_Site|BLNK_uc001kmc.3_RNA|BLNK_uc001kmd.3_Silent_p.G35G|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	117	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		CTATATACTCGCCTCTGGCGA	0.652													35	61					0	0	0	0	A	97987176	A	A	97987176	2	1	225	1	0	0	0	0	0	0	0	1	1450	1074	38	1		1	BLNK	10	97987176	Silent	SNP	G	TCGA-CV-7103-01A-21D-2012-08	86481822	97987176	37547571	32	41322											
NRAP	4892	broad.mit.edu	37	chr10	115391662	115391662	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggcggccagcagagacatgGcatccagcttcatctcaaat	11	8	10	12	1	2	1	2	0	1	1	4	2	3	1	2	3	2	3	2	3	1	1			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr10:115391662G>A	uc001laj.2	-	17	1858	c.1694C>T	c.(1693-1695)GCC>GTC	p.A565V	NRAP_uc009xyb.2_5'Flank|NRAP_uc001lak.2_Missense_Mutation_p.A530V|NRAP_uc001lal.3_Missense_Mutation_p.A565V	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	565	Nebulin 13.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CAGAGACATGGCATCCAGCTT	0.448													53	74					0	0	0	0	A	115391662	A	A	115391662	3	1	225	1	0	0	0	0	1	0	0	0	10692	1203	42	4	3602	4	NRAP	10	115391662	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08	17404486	115391662	20143085	33	41323											
PCNXL3	399909	broad.mit.edu	37	chr11	65402557	65402557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcttcaccgcgttgtggCgcctggggttcgcatggccc	2	10	14	15	4	1	0	1	0	0	0	2	0	1	0	4	4	1	4	4	4	0	3			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr11:65402557C>T	uc001oey.2	+	30	4919	c.4919C>T	c.(4918-4920)GCG>GTG	p.A1640V	PCNXL3_uc001oez.2_Missense_Mutation_p.A527V	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1640						integral to membrane					0						CGCGTTGTGGCGCCTGGGGTT	0.647													10	26					0	0	0	0	T	65402557	T	T	65402557	3	4	225	1	0	0	0	0	1	0	0	0	11647	768	27	1	5037	1	PCNXL3	11	65402557	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08		65402557	69603959	34	41324											
HEPACAM	220296	broad.mit.edu	37	chr11	124794765	124794765	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aaagagtcggatacggtctcGatagtcaggccgcagggtgc	10	7	15	9	4	2	1	1	0	1	1	4	3	2	2	1	4	2	1	1	4	3	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr11:124794765G>C	uc001qbk.2	-	2	692	c.286C>G	c.(286-288)CGA>GGA	p.R96G	HEPACAM_uc009zbj.2_5'Flank|HEPACAM_uc001qbl.1_Missense_Mutation_p.R96G	NM_152722	NP_689935	Q14CZ8	HECAM_HUMAN	hepatocyte cell adhesion molecule precursor	96	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		ATACGGTCTCGATAGTCAGGC	0.592													45	74					0	0	0	0	C	124794765	C	C	124794765	3	2	225	1	0	0	0	0	1	0	0	0	7091	1066	37	3	988	3	HEPACAM	11	124794765	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08	59392208	124794765	10211751	35	41325											
ENO2	2026	broad.mit.edu	37	chr12	7025014	7025014	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcatgtccatagagaagatCtgggcccgggagatcctgga	11	8	13	9	1	2	3	1	0	1	3	4	6	4	4	3	3	0	0	3	3	2	1			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr12:7025014C>T	uc001qru.1	+	2	240	c.18C>T	c.(16-18)ATC>ATT	p.I6I	ENO2_uc009zfi.1_Silent_p.I6I|ENO2_uc010sfq.1_Silent_p.I6I|ENO2_uc001qrv.1_Silent_p.I6I	NM_001975	NP_001966	P09104	ENOG_HUMAN	enolase 2	6					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex|plasma membrane	magnesium ion binding|phosphopyruvate hydratase activity				0						TAGAGAAGATCTGGGCCCGGG	0.577													64	282					0	0	0	0	T	7025014	T	T	7025014	2	4	225	1	0	0	0	0	0	0	0	1	5146	903	32	2		2	ENO2	12	7025014	Silent	SNP	C	TCGA-CV-7103-01A-21D-2012-08		7025014	126826881	36	41326											
ADCY6	112	broad.mit.edu	37	chr12	49176996	49176996	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttgcccttgcctgggccGcccctccggatgaaggcgtc	3	9	12	17	3	0	1	0	1	0	0	3	2	2	2	7	3	2	0	7	3	1	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr12:49176996G>A	uc001rsh.3	-	1	882	c.222C>T	c.(220-222)GGC>GGT	p.G74G	ADCY6_uc001rsj.3_Silent_p.G74G|ADCY6_uc001rsi.3_Silent_p.G74G	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	74	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						TGCCTGGGCCGCCCCTCCGGA	0.721													22	35					0	0	0	0	A	49176996	A	A	49176996	2	1	225	1	0	0	0	0	0	0	0	1	298	1074	38	1		1	ADCY6	12	49176996	Silent	SNP	G	TCGA-CV-7103-01A-21D-2012-08	42151982	49176996	84674899	37	41327											
DNAJC14	85406	broad.mit.edu	37	chr12	56182870	56182870	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctacattacctttctggagaTtgaagagacattcaaaccaa	15	11	6	9	0	2	3	1	1	1	2	2	5	2	3	2	1	3	0	2	1	5	5	rs138765992		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr12:56182870T>C	uc001shu.1	-	14	2595	c.2539A>G	c.(2539-2541)ATC>GTC	p.I847V	SARNP_uc009zoa.2_RNA|SARNP_uc001shs.3_RNA|SARNP_uc001sht.2_Missense_Mutation_p.I164V	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	Error:Variant_position_missing_in_Q6Y2X3_after_alignment					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						TTTCTGGAGATTGAAGAGACA	0.368													30	70					0	0	0	0	C	56182870	C	C	56182870	3	2	225	1	0	0	0	0	1	0	0	0	4655	1493	52	5		5	DNAJC14	12	56182870	Missense_Mutation	SNP	T	TCGA-CV-7103-01A-21D-2012-08	7005874	56182870	77669025	38	41328											
UBE3B	89910	broad.mit.edu	37	chr12	109972570	109972570	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acgccatcagcatgaacacgGgctttgaactctcctagctc	10	9	8	14	2	2	2	1	2	1	0	4	2	2	2	2	1	4	3	2	1	3	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr12:109972570G>T	uc001top.2	+	28	3793	c.3190G>T	c.(3190-3192)GGC>TGC	p.G1064C	UBE3B_uc001toq.2_Missense_Mutation_p.G1064C|UBE3B_uc001tos.2_Missense_Mutation_p.G491C|UBE3B_uc001tot.2_Missense_Mutation_p.G182C|UBE3B_uc010sxp.1_3'UTR	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	1064	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CATGAACACGGGCTTTGAACT	0.617													5	91					0.000602214	0.00742084	1	0	T	109972570	T	T	109972570	3	4	225	1	0	0	0	0	1	0	0	0	16948	1232	43	4	3292	4	UBE3B	12	109972570	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08	53789700	109972570	23879325	39	41329											
FREM2	341640	broad.mit.edu	37	chr13	39262438	39262438	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgagaacactgcacccaaGcccagtttcgtggccatgat	10	7	10	14	2	0	2	0	1	0	1	1	3	0	2	4	1	3	2	4	1	2	1			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr13:39262438G>A	uc001uwv.2	+	1	1266	c.957G>A	c.(955-957)AAG>AAA	p.K319K		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	319	CSPG 1.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CTGCACCCAAGCCCAGTTTCG	0.607													20	22					0	0	0	0	A	39262438	A	A	39262438	2	1	225	1	0	0	0	0	0	0	0	1	6079	962	34	4		4	FREM2	13	39262438	Silent	SNP	G	TCGA-CV-7103-01A-21D-2012-08		39262438	75907440	40	41330											
PKM2	5315	broad.mit.edu	37	chr15	72501133	72501133	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatcctggatgtccttctccGacacagcaggcaagtccaca	10	8	9	14	1	1	0	0	0	1	0	5	3	4	1	4	2	1	2	4	2	1	1	rs143294717		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr15:72501133G>A	uc002atx.1	-	6	906	c.665C>T	c.(664-666)TCG>TTG	p.S222L	PKM2_uc002ats.1_5'Flank|PKM2_uc002att.1_5'UTR|PKM2_uc002atu.1_5'UTR|PKM2_uc010bit.1_Missense_Mutation_p.S227L|PKM2_uc010uki.1_Missense_Mutation_p.S296L|PKM2_uc002atv.1_Missense_Mutation_p.S257L|PKM2_uc002atw.1_Missense_Mutation_p.S222L|PKM2_uc002aty.1_Missense_Mutation_p.S222L|PKM2_uc010ukj.1_Missense_Mutation_p.S207L|PKM2_uc010ukk.1_Missense_Mutation_p.S148L|PKM2_uc010biu.1_Missense_Mutation_p.S243L|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	222					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	GTCCTTCTCCGACACAGCAGG	0.547													36	78					0	0	0	0	A	72501133	A	A	72501133	3	1	225	1	0	0	0	0	1	0	0	0	12032	1059	37	1	1125	1	PKM2	15	72501133	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08		72501133	30030259	41	41331											
PRSS22	64063	broad.mit.edu	37	chr16	2905603	2905603	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgctcccccagcctgaGatccagcagtgggtgtttgg	6	10	14	11	0	0	1	0	1	0	1	2	3	2	2	4	3	3	3	4	3	0	1			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr16:2905603G>T	uc002cry.1	-	4	597	c.531C>A	c.(529-531)ATC>ATA	p.I177I	PRSS22_uc002crz.1_Intron	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	177	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						CCCAGCCTGAGATCCAGCAGT	0.602													14	48					2.61681e-11	3.57008e-10	1	0	T	2905603	T	T	2905603	2	4	225	1	0	0	0	0	0	0	0	1	12681	932	33	2		2	PRSS22	16	2905603	Silent	SNP	G	TCGA-CV-7103-01A-21D-2012-08		2905603	87449150	42	41332											
TP53	7157	broad.mit.edu	37	chr17	7578471	7578478	+	Frame_Shift_Del	DEL	GGGCGGGG	-	-																															atggcgcggacgcgggtgccGggcgggggtgtggaatcaac																								rs137852791		TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr17:7578471_7578478delGGGCGGGG	uc002gim.2	-	5	646_653	c.452_459delCCCCGCCC	c.(451-459)CCCCCGCCCfs	p.P151fs	TP53_uc002gig.1_Frame_Shift_Del_p.P151fs|TP53_uc002gih.2_Frame_Shift_Del_p.P151fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.P19fs|TP53_uc010cng.1_Frame_Shift_Del_p.P19fs|TP53_uc002gii.1_Frame_Shift_Del_p.P19fs|TP53_uc010cnh.1_Frame_Shift_Del_p.P151fs|TP53_uc010cni.1_Frame_Shift_Del_p.P151fs|TP53_uc002gij.2_Frame_Shift_Del_p.P151fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.P58fs|TP53_uc002gio.2_Frame_Shift_Del_p.P19fs|TP53_uc010vug.1_Frame_Shift_Del_p.P112fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	151_153	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> T (in sporadic cancers; somatic mutation).|P -> R (in a sporadic cancer; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> H (in a sporadic cancer; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|P -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.P152L(57)|p.P151H(25)|p.P152S(21)|p.P151T(13)|p.P151P(12)|p.P153fs*28(10)|p.P153S(8)|p.P151A(8)|p.P152T(7)|p.0?(7)|p.P153P(7)|p.P151fs*30(7)|p.P151L(6)|p.P152fs*18(6)|p.P151R(6)|p.P153L(6)|p.P152fs*29(5)|p.P152P(5)|p.P152Q(4)|p.P152fs*14(4)|p.P152R(3)|p.P153T(3)|p.G154fs*27(3)|p.T150fs*16(3)|p.G154fs*16(2)|p.P152A(2)|p.P152fs*28(2)|p.P153fs*26(2)|p.P153fs*22(2)|p.P153fs*16(1)|p.P151_V173del23(1)|p.T150_P153delTPPP(1)|p.P152_P153del(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.P153fs*20(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P152_P153insXXX(1)|p.P153_G154insX(1)|p.P153F(1)|p.P153A(1)|p.T150_P151delTP(1)|p.P153H(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGCGGGTGCCGGGCGGGGGTGTGGAATC	0.606		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578478	-	-	7578471	7	5	225	1	0	1	0	1	0	0	0	0	16448	1103	39	0	839	0	TP53	17	7578471	Frame_Shift_Del	DEL	GGGCGGGG	TCGA-CV-7103-01A-21D-2012-08		7578471	73616739	43	41333											
STAC2	342667	broad.mit.edu	37	chr17	37371437	37371437	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatcagtgccagggaggtGccatagcgcagggtctcgta	8	9	14	10	2	3	0	2	0	1	0	4	1	3	1	2	3	3	2	2	3	2	3			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr17:37371437G>A	uc002hrs.2	-	5	852	c.633C>T	c.(631-633)GGC>GGT	p.G211G	STAC2_uc010cvt.2_Silent_p.G69G	NM_198993	NP_945344	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	211					intracellular signal transduction		metal ion binding			pancreas(1)	1						CCAGGGAGGTGCCATAGCGCA	0.592													32	59					0	0	0	0	A	37371437	A	A	37371437	2	1	225	1	0	0	0	0	0	0	0	1	15306	1306	46	4		4	STAC2	17	37371437	Silent	SNP	G	TCGA-CV-7103-01A-21D-2012-08	29792966	37371437	43823773	44	41334											
LIPG	9388	broad.mit.edu	37	chr18	47101893	47101893	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtgggccacattgacatctaCcccaatgggggtgacttcca	9	9	11	12	0	1	2	0	2	1	0	2	2	2	2	4	3	1	0	4	3	2	3			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr18:47101893C>T	uc002ldv.2	+	5	978	c.726C>T	c.(724-726)TAC>TAT	p.Y242Y	LIPG_uc002ldu.1_Silent_p.Y242Y|LIPG_uc010xdh.1_Intron	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	242					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						TTGACATCTACCCCAATGGGG	0.507													8	85					0	0	0	0	T	47101893	T	T	47101893	2	4	225	1	0	0	0	0	0	0	0	1	8865	518	18	4		4	LIPG	18	47101893	Silent	SNP	C	TCGA-CV-7103-01A-21D-2012-08		47101893	30975355	45	41335											
RPL36	25873	broad.mit.edu	37	chr19	5691333	5691333	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccctttcccccctagcgtCtgaccaaacacaccaagttc	9	8	5	19	1	1	1	0	1	1	0	3	1	2	1	7	0	2	1	7	0	3	3			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:5691333C>G	uc002mcv.2	+	3	166	c.97C>G	c.(97-99)CTG>GTG	p.L33V	RPL36_uc002mcw.2_Missense_Mutation_p.L33V	NM_033643	NP_378669	Q9Y3U8	RL36_HUMAN	ribosomal protein L36	33					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|structural constituent of ribosome				0						CCCCTAGCGTCTGACCAAACA	0.602											OREG0025183	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	68					0	0	0	0	G	5691333	G	G	5691333	3	3	225	1	0	0	0	0	1	0	0	0	13651	912	32	2	103	2	RPL36	19	5691333	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08		5691333	53437650	46	41336											
MUC16	94025	broad.mit.edu	37	chr19	9074800	9074800	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctcaaattgggaggtaaacTtgtgccaggttccaagctta	11	11	11	8	0	1	0	1	0	0	0	2	1	2	1	2	3	3	4	2	3	5	5			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:9074800T>G	uc002mkp.2	-	3	12850	c.12646A>C	c.(12646-12648)AGT>CGT	p.S4216R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4218	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAGGTAAACTTGTGCCAGGT	0.498													11	62					0	0	0	0	G	9074800	G	G	9074800	3	3	225	1	0	0	0	0	1	0	0	0	10026	1609	56	5	31205	5	MUC16	19	9074800	Missense_Mutation	SNP	T	TCGA-CV-7103-01A-21D-2012-08	3383467	9074800	50054183	47	41337											
COL5A3	50509	broad.mit.edu	37	chr19	10077031	10077032	+	Missense_Mutation	DNP	CC	TT	TT																															atagaggcaggtctctcctcCcgccgtgaagttgcaaaaaa																										TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:10077031_10077032CC>TT	uc002mmq.1	-	64	4826_4827	c.4740_4741GG>AA	c.(4738-4743)GCGGGA>GCAAGA	p.G1581R		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1581	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GTCTCTCCTCCCGCCGTGAAGT	0.599													19	26					0	0	0	0	TT	10077032	TT	TT	10077031	3	4	225	1	0	0	0	0	1	0	0	0	3713	632	22	4	512	4	COL5A3	19	10077031	Missense_Mutation	DNP	CC	TCGA-CV-7103-01A-21D-2012-08	1002231	10077031	49051952	48	41338											
NWD1	284434	broad.mit.edu	37	chr19	16902349	16902349	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcaacatatgtccagcatCaaagaagaaacacctacctg	18	6	6	11	0	1	2	1	0	0	2	2	2	2	2	3	0	5	2	3	0	7	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:16902349C>G	uc002neu.3	+	14	3551	c.3129C>G	c.(3127-3129)ATC>ATG	p.I1043M	NWD1_uc002net.3_Missense_Mutation_p.I908M|NWD1_uc002nev.3_Missense_Mutation_p.I837M			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	1043							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						TGTCCAGCATCAAAGAAGAAA	0.517													34	69					0	0	0	0	G	16902349	G	G	16902349	3	3	225	1	0	0	0	0	1	0	0	0	10835	816	29	2	2762	2	NWD1	19	16902349	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08	6825318	16902349	42226634	49	41339											
ZNF737	100129842	broad.mit.edu	37	chr19	20728546	20728546	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttgaatttgaaaatttatGaatgactttcacatatttat	14	19	5	3	0	1	4	1	4	0	0	1	4	1	4	0	0	0	1	0	0	7	8			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:20728546G>C	uc002npa.2	-	4	643	c.463C>G	c.(463-465)CAT>GAT	p.H155D		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	155					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GAAAATTTATGAATGACTTTC	0.308													17	29					0	0	0	0	C	20728546	C	C	20728546	3	2	225	1	0	0	0	0	1	0	0	0	18193	1290	45	2	1151	2	ZNF737	19	20728546	Missense_Mutation	SNP	G	TCGA-CV-7103-01A-21D-2012-08	3826197	20728546	38400437	50	41340											
ZNF383	163087	broad.mit.edu	37	chr19	37733547	37733547	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgggatatccaaatgggCattttagtcaagaaatattc	15	12	8	6	0	1	1	1	0	0	1	3	2	2	2	1	2	1	1	1	2	7	5			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:37733547C>G	uc002oft.1	+	8	989	c.409C>G	c.(409-411)CAT>GAT	p.H137D	ZNF383_uc002ofs.1_Missense_Mutation_p.H72D|ZNF383_uc002ofu.1_Missense_Mutation_p.H137D	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCCAAATGGGCATTTTAGTCA	0.373													49	109					0	0	0	0	G	37733547	G	G	37733547	3	3	225	1	0	0	0	0	1	0	0	0	17941	710	25	4	423	4	ZNF383	19	37733547	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08	17005001	37733547	21395436	51	41341											
ZSCAN5A	79149	broad.mit.edu	37	chr19	56732960	56732960	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatcactgagaagtagctTctggatgtgttttctggtgg	8	14	13	6	0	3	1	1	1	2	1	3	3	3	2	0	3	1	4	0	3	3	4			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chr19:56732960T>G	uc002qmq.2	-	5	1641	c.1475A>C	c.(1474-1476)GAA>GCA	p.E492A	ZSCAN5A_uc010ygi.1_Missense_Mutation_p.E375A|ZSCAN5A_uc002qmr.2_Missense_Mutation_p.E492A|ZSCAN5A_uc002qms.1_Missense_Mutation_p.E491A	NM_024303	NP_077279	Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	492					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						AGAAGTAGCTTCTGGATGTGT	0.433													30	50					0	0	0	0	G	56732960	G	G	56732960	3	3	225	1	0	0	0	0	1	0	0	0	18305	1783	62	5	19	5	ZSCAN5A	19	56732960	Missense_Mutation	SNP	T	TCGA-CV-7103-01A-21D-2012-08	18999413	56732960	2396023	52	41342											
ARMCX2	9823	broad.mit.edu	37	chrX	100911661	100911661	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagcccatccccagttcgTctacttcaactttgcttttc	7	14	6	14	1	2	0	1	0	1	0	5	1	3	1	3	1	4	2	3	1	3	6			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chrX:100911661T>C	uc004eid.2	-	3	1269	c.914A>G	c.(913-915)GAC>GGC	p.D305G	ARMCX2_uc004eie.3_Missense_Mutation_p.D305G|ARMCX2_uc004eif.3_Missense_Mutation_p.D305G|ARMCX2_uc004eig.3_Missense_Mutation_p.D305G|ARMCX2_uc010nnt.2_Missense_Mutation_p.D305G	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	305						integral to membrane	binding	p.D305D(1)		ovary(6)	6						CCCCAGTTCGTCTACTTCAAC	0.587													64	27					0	0	0	0	C	100911661	C	C	100911661	3	2	225	1	0	0	0	0	1	0	0	0	962	1667	58	5	988	5	ARMCX2	23	100911661	Missense_Mutation	SNP	T	TCGA-CV-7103-01A-21D-2012-08		100911661	54358899	53	41343											
ZNF449	203523	broad.mit.edu	37	chrX	134483238	134483238	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcagaactttctggacccTggtaaggcaagggtttctct	8	13	11	9	0	3	1	1	0	2	1	4	2	3	2	1	4	1	3	1	4	3	3			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chrX:134483238T>G	uc004eys.2	+	3	723	c.558T>G	c.(556-558)CCT>CCG	p.P186P	ZNF449_uc004eyq.1_3'UTR|ZNF449_uc004eyt.2_Silent_p.P66P	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	186					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCTGGACCCTGGTAAGGCAA	0.512													16	39					0	0	0	0	G	134483238	G	G	134483238	2	3	225	1	0	0	0	0	0	0	0	1	17987	1594	55	5		5	ZNF449	23	134483238	Silent	SNP	T	TCGA-CV-7103-01A-21D-2012-08	33571577	134483238	20787322	54	41344											
OPN1LW	5956	broad.mit.edu	37	chrX	153420103	153420103	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagacgtgttcagcggcagCtcgtaccccggggtgcagtc	6	7	14	14	4	1	1	1	0	0	1	3	1	1	1	3	3	4	5	3	3	1	2			TCGA-CV-7103-01A-21D-2012-08	TCGA-CV-7103-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e04f3556-ae16-410d-bc03-1057ae308329	7c493e26-33c4-495d-ad0c-a9fb423124fa	g.chrX:153420103C>A	uc004fjz.3	+	4	666	c.633C>A	c.(631-633)AGC>AGA	p.S211R		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	211	Extracellular.				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCAGCGGCAGCTCGTACCCCG	0.607													45	16					2.69953e-25	3.81934e-24	1	0	A	153420103	A	A	153420103	3	1	225	1	0	0	0	0	1	0	0	0	10931	796	28	4	647	4	OPN1LW	23	153420103	Missense_Mutation	SNP	C	TCGA-CV-7103-01A-21D-2012-08	18936865	153420103	1850457	55	41345											
CLSTN1	22883	broad.mit.edu	37	chr1	9804038	9804038	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccggcacccgtggacataGagggagtagtggtgccgatt	9	7	16	9	3	0	1	0	0	0	1	0	4	0	3	3	4	2	2	3	4	2	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:9804038G>C	uc001aqh.2	-	9	2019	c.1260C>G	c.(1258-1260)CTC>CTG	p.L420L	CLSTN1_uc001aqi.2_Silent_p.L410L|CLSTN1_uc010oag.1_Silent_p.L420L	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	calsyntenin 1 isoform 1	420	Extracellular (Potential).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		CGTGGACATAGAGGGAGTAGT	0.458													34	72					0	0	0	0	C	9804038	C	C	9804038	2	2	226	1	0	0	0	0	0	0	0	1	3576	929	33	2		2	CLSTN1	1	9804038	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08		9804038	239446583	1	41346											
EPHA2	1969	broad.mit.edu	37	chr1	16475417	16475418	+	Frame_Shift_Ins	INS	-	CGCT	CGCT																															acttgagctcaatgaagataINScgctcagcctctcctcggta																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:16475417_16475418insCGCT	uc001aya.1	-	3	415_416	c.278_279insAGCG	c.(277-279)CGTfs	p.R93fs	EPHA2_uc010oca.1_Frame_Shift_Ins_p.R93fs	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	93	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CAATGAAGATACGCTCAGCCTC	0.545													---	---	---								CGCT	16475418	CGCT	CGCT	16475417	7	5	226	1	0	1	1	0	0	0	0	0	5191	378	14	0	2711	0	EPHA2	1	16475417	Frame_Shift_Ins	INS	-	TCGA-CV-7104-01A-11D-2012-08	6671379	16475417	232775204	2	41347											
KIAA1522	57648	broad.mit.edu	37	chr1	33237578	33237578	+	Frame_Shift_Del	DEL	C	-	-																															ctcctcagggctccatgctgCggtccgactcaaggcctgca																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:33237578delC	uc001bvv.2	+	6	2757	c.2621delC	c.(2620-2622)GCGfs	p.A874fs	KIAA1522_uc001bvu.1_Frame_Shift_Del_p.A933fs|KIAA1522_uc010ohm.1_Frame_Shift_Del_p.A885fs|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	874	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CTCCATGCTGCGGTCCGACTC	0.706													---	---	---								-	33237578	-	-	33237578	7	5	226	1	0	1	0	1	0	0	0	0	8277	768	27	0	2820	0	KIAA1522	1	33237578	Frame_Shift_Del	DEL	C	TCGA-CV-7104-01A-11D-2012-08	16762161	33237578	216013043	3	41348											
ZMYM1	79830	broad.mit.edu	37	chr1	35578796	35578798	+	In_Frame_Del	DEL	TAT	-	-																															gttaaaggtaaatcacgaagTattaaaaaatcttgttgtgc																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:35578796_35578798delTAT	uc001bym.2	+	11	1513_1515	c.1365_1367delTAT	c.(1363-1368)AGTATT>AGT	p.I456del	ZMYM1_uc001byn.2_In_Frame_Del_p.I456del|ZMYM1_uc010ohu.1_In_Frame_Del_p.I437del|ZMYM1_uc001byo.2_In_Frame_Del_p.I96del|ZMYM1_uc009vut.2_In_Frame_Del_p.I381del	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	456	TTF-type.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AATCACGAAGTATTAAAAAATCT	0.3													---	---	---								-	35578798	-	-	35578796	7	5	226	1	0	1	0	1	0	0	0	0	17766	1635	57	0	1399	0	ZMYM1	1	35578796	In_Frame_Del	DEL	TAT	TCGA-CV-7104-01A-11D-2012-08	2341218	35578796	213671825	4	41349											
CAP1	10487	broad.mit.edu	37	chr1	40525048	40525048	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcaaaatctggtagaaagAttggagagggcagtgggccg	13	7	16	5	1	1	3	0	0	1	3	1	4	1	3	1	4	1	3	1	4	4	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:40525048A>T	uc001cfa.3	+	2	259	c.30A>T	c.(28-30)AGA>AGT	p.R10S	CAP1_uc010ojd.1_RNA|CAP1_uc001cey.3_Missense_Mutation_p.R10S|CAP1_uc001cez.3_Missense_Mutation_p.R10S|CAP1_uc009vvz.2_Missense_Mutation_p.R10S|CAP1_uc010oje.1_5'UTR	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	10					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGGTAGAAAGATTGGAGAGGG	0.453													27	69					0	0	0	0	T	40525048	T	T	40525048	3	4	226	1	0	0	0	0	1	0	0	0	2631	330	12	5	32	5	CAP1	1	40525048	Missense_Mutation	SNP	A	TCGA-CV-7104-01A-11D-2012-08	4946252	40525048	208725573	5	41350											
RLF	6018	broad.mit.edu	37	chr1	40661333	40661334	+	Missense_Mutation	DNP	GA	AT	AT																															gatgcattattggaatttggGaataataacctacaaatatt																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:40661333_40661334GA>AT	uc001cfc.3	+	4	535_536	c.504_505GA>AT	c.(502-507)GGGAAT>GGATAT	p.N169Y		NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	169					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TGGAATTTGGGAATAATAACCT	0.356													11	29					0	0	0	0	AT	40661334	AT	AT	40661333	3	1	226	1	0	0	0	0	1	0	0	0	13454	1161	41	2	518	2	RLF	1	40661333	Missense_Mutation	DNP	GA	TCGA-CV-7104-01A-11D-2012-08	136285	40661333	208589288	6	41351											
POMGNT1	55624	broad.mit.edu	37	chr1	46658985	46658985	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctatgcagtacctgagacaCgcgggcattcttgatgctga	9	10	11	11	2	1	3	0	3	1	1	1	4	1	3	2	1	3	4	2	1	2	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:46658985C>T	uc001cpe.2	-	12	1266	c.1102G>A	c.(1102-1104)GTG>ATG	p.V368M	POMGNT1_uc010olx.1_Missense_Mutation_p.V346M|POMGNT1_uc010oly.1_RNA|POMGNT1_uc010olz.1_Missense_Mutation_p.V225M|POMGNT1_uc001cpg.2_Missense_Mutation_p.V368M|POMGNT1_uc001cpf.2_Missense_Mutation_p.V35M|POMGNT1_uc001cph.1_5'Flank|POMGNT1_uc001cpi.1_Missense_Mutation_p.V35M	NM_017739	NP_060209	Q8WZA1	PMGT1_HUMAN	O-linked mannose	368	Lumenal (Potential).				protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACCTGAGACACGCGGGCATTC	0.587													13	23					0	0	0	0	T	46658985	T	T	46658985	3	4	226	1	0	0	0	0	1	0	0	0	12298	536	19	1	924	1	POMGNT1	1	46658985	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	5997652	46658985	202591636	7	41352											
AK5	26289	broad.mit.edu	37	chr1	77984359	77984359	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaactggcatcagaatctGaaagaagcaaattgatcaga	18	7	10	6	0	3	5	2	2	1	3	3	6	3	6	0	2	2	2	0	2	5	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:77984359G>T	uc001dhn.2	+	11	1515	c.1258G>T	c.(1258-1260)GAA>TAA	p.E420*	AK5_uc001dho.2_Nonsense_Mutation_p.E394*	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	420					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						ATCAGAATCTGAAAGAAGCAA	0.488													19	49					1.56452e-12	9.15491e-12	1	0	T	77984359	T	T	77984359	4	4	226	1	0	0	0	0	0	1	0	0	443	1291	45	2	1300	2	AK5	1	77984359	Nonsense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	31325374	77984359	171266262	8	41353											
CSDE1	7812	broad.mit.edu	37	chr1	115267850	115267850	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaatttattacctgagtgtGttttgttcactttttctgca	8	20	6	7	0	2	1	1	1	1	0	2	1	2	1	1	0	2	3	1	0	3	8			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:115267850G>A	uc001efk.2	-	15	2211	c.1745C>T	c.(1744-1746)ACA>ATA	p.T582I	CSDE1_uc001efi.2_Missense_Mutation_p.T628I|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.T551I|CSDE1_uc001efm.2_Missense_Mutation_p.T597I|CSDE1_uc009wgv.2_Missense_Mutation_p.T582I|CSDE1_uc001efn.2_Missense_Mutation_p.T551I	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	582					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACCTGAGTGTGTTTTGTTCAC	0.423													44	121					0	0	0	0	A	115267850	A	A	115267850	3	1	226	1	0	0	0	0	1	0	0	0	3946	1377	48	4	675	4	CSDE1	1	115267850	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	37283491	115267850	133982771	9	41354											
S100A11	6282	broad.mit.edu	37	chr1	152005278	152005278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcttcatcatgcggtcaaGgacaccagggtccttctggt	7	13	10	11	1	5	0	3	0	2	0	6	1	6	1	2	4	1	0	2	4	1	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:152005278G>A	uc001ezn.2	-	3	298	c.178C>T	c.(178-180)CTT>TTT	p.L60F	uc001ezm.1_Intron	NM_005620	NP_005611	P31949	S10AB_HUMAN	S100 calcium binding protein A11	60	EF-hand 2.				negative regulation of cell proliferation|negative regulation of DNA replication|signal transduction	cytoplasm|nucleus|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|S100 beta binding				0	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			ATGCGGTCAAGGACACCAGGG	0.308													10	54					0	0	0	0	A	152005278	A	A	152005278	3	1	226	1	0	0	0	0	1	0	0	0	13838	1000	35	4	143	4	S100A11	1	152005278	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	36737428	152005278	97245343	10	41355											
DENND4B	9909	broad.mit.edu	37	chr1	153905172	153905172	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agagcaaggcagagccttcgGtcactgagcacagggccagg	11	4	15	11	1	1	3	1	1	0	2	2	3	1	3	2	4	3	3	2	4	1	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:153905172G>A	uc001fdd.1	-	23	4106	c.3705C>T	c.(3703-3705)GAC>GAT	p.D1235D	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1235										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AGAGCCTTCGGTCACTGAGCA	0.627													22	62					0	0	0	0	A	153905172	A	A	153905172	2	1	226	1	0	0	0	0	0	0	0	1	4456	1252	44	4		4	DENND4B	1	153905172	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	1899894	153905172	95345449	11	41356											
BLZF1	8548	broad.mit.edu	37	chr1	169345895	169345895	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcatcatagtcttcagaGtccatggaagaaagcagttc	15	9	9	8	0	3	2	2	0	1	2	5	3	4	3	1	1	2	3	1	1	4	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:169345895G>C	uc001gfx.1	+	3	583	c.146G>C	c.(145-147)AGT>ACT	p.S49T	BLZF1_uc001gfw.2_Missense_Mutation_p.S49T|BLZF1_uc001gfy.2_Missense_Mutation_p.S49T|BLZF1_uc009wvp.1_Missense_Mutation_p.S26T	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	49					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					AGTCTTCAGAGTCCATGGAAG	0.438													15	54					0	0	0	0	C	169345895	C	C	169345895	3	2	226	1	0	0	0	0	1	0	0	0	1456	1029	36	4	152	4	BLZF1	1	169345895	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	15440723	169345895	79904726	12	41357											
PIGC	5279	broad.mit.edu	37	chr1	172411603	172411603	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggatcaccacactggactCaaataccacagcccaatatt	14	8	5	14	0	2	0	2	0	0	0	2	2	2	2	3	2	2	0	3	2	4	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:172411603C>T	uc001gil.2	-	2	441	c.160G>A	c.(160-162)GAG>AAG	p.E54K	PIGC_uc001gii.1_Intron|PIGC_uc001gij.1_Intron|C1orf105_uc001gik.2_Intron|PIGC_uc001gin.2_Missense_Mutation_p.E54K|PIGC_uc001gio.2_Missense_Mutation_p.E54K	NM_153747	NP_714969	Q92535	PIGC_HUMAN	phosphatidylinositol glycan, class C	54	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			lung(1)	1						ACACTGGACTCAAATACCACA	0.498													32	109					0	0	0	0	T	172411603	T	T	172411603	3	4	226	1	0	0	0	0	1	0	0	0	11941	835	29	2	737	2	PIGC	1	172411603	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	3065708	172411603	76839018	13	41358											
USH2A	7399	broad.mit.edu	37	chr1	216462695	216462695	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtttgcaaacatctatggccGaaggatctgcaccaacttgt	11	11	9	10	1	2	0	0	0	2	0	2	2	2	1	2	2	4	3	2	2	4	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:216462695G>C	uc001hku.1	-	11	2285	c.1898C>G	c.(1897-1899)TCG>TGG	p.S633W	USH2A_uc001hkv.2_Missense_Mutation_p.S633W	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	633	Laminin EGF-like 2.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATCTATGGCCGAAGGATCTGC	0.408										HNSCC(13;0.011)			17	54					0	0	0	0	C	216462695	C	C	216462695	3	2	226	1	0	0	0	0	1	0	0	0	17104	1059	37	3	13972	3	USH2A	1	216462695	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	44051092	216462695	32787926	14	41359											
FMN2	56776	broad.mit.edu	37	chr1	240492663	240492663	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctttatgaactgtcactaatCcccaacttttcagagcgagt	11	13	6	11	1	2	2	2	1	0	1	3	3	3	2	2	0	3	0	2	0	4	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr1:240492663C>A	uc010pyd.1	+	10	4557	c.4332C>A	c.(4330-4332)ATC>ATA	p.I1444I	FMN2_uc010pye.1_Silent_p.I1448I|FMN2_uc010pyf.1_Silent_p.I90I|FMN2_uc010pyg.1_Silent_p.I40I	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1444	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TGTCACTAATCCCCAACTTTT	0.358													16	64					1.3612e-06	7.44191e-06	1	0	A	240492663	A	A	240492663	2	1	226	1	0	0	0	0	0	0	0	1	5982	845	30	2		2	FMN2	1	240492663	Silent	SNP	C	TCGA-CV-7104-01A-11D-2012-08	24029968	240492663	8757958	15	41360											
FOSL2	2355	broad.mit.edu	37	chr2	28634924	28634925	+	Frame_Shift_Ins	INS	-	GC	GC																															tgcaagattagccccgaggaINSgcgccgatcgcccccagccc																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr2:28634924_28634925insGC	uc002rma.2	+	4	1399_1400	c.590_591insGC	c.(589-591)GAGfs	p.E197fs	FOSL2_uc010ymi.1_Frame_Shift_Ins_p.E158fs	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	197					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					AGCCCCGAGGAGCGCCGATCGC	0.639													---	---	---								GC	28634925	GC	GC	28634924	7	5	226	1	0	1	1	0	0	0	0	0	6020	304	11	0	604	0	FOSL2	2	28634924	Frame_Shift_Ins	INS	-	TCGA-CV-7104-01A-11D-2012-08		28634924	214564449	16	41361											
ST6GAL2	84620	broad.mit.edu	37	chr2	107459965	107459965	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaagccccctcccgtgggcCtggctccccgggggaaggga	7	4	15	15	2	0	0	0	0	0	0	2	2	2	2	6	5	1	1	6	5	3	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr2:107459965C>T	uc002tdq.2	-	2	588	c.469G>A	c.(469-471)GGC>AGC	p.G157S	ST6GAL2_uc002tdr.2_Missense_Mutation_p.G157S|ST6GAL2_uc002tds.3_Missense_Mutation_p.G157S	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	157	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						TCCCGTGGGCCTGGCTCCCCG	0.632													52	129					0	0	0	0	T	107459965	T	T	107459965	3	4	226	1	0	0	0	0	1	0	0	0	15288	681	24	4	1227	4	ST6GAL2	2	107459965	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	78825041	107459965	135739408	17	41362											
KCNJ3	3760	broad.mit.edu	37	chr2	155711297	155711297	+	Frame_Shift_Del	DEL	T	-	-																															gaagttctttggggtcatcgTttttttcctgtaatttcctt																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr2:155711297delT	uc002tyv.1	+	3	1173	c.978delT	c.(976-978)CGTfs	p.R326fs	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	326	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	GGGGTCATCGTTTTTTTCCTG	0.383													---	---	---								-	155711297	-	-	155711297	7	5	226	1	0	1	0	1	0	0	0	0	8091	1712	60	0	988	0	KCNJ3	2	155711297	Frame_Shift_Del	DEL	T	TCGA-CV-7104-01A-11D-2012-08	48251332	155711297	87488076	18	41363											
TTN	7273	broad.mit.edu	37	chr2	179616392	179616392	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actattaattgctagtaaccTataacttccagaatctctgt	13	15	4	9	0	1	1	0	0	1	1	3	1	2	1	2	0	3	2	2	0	7	8			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr2:179616392T>C	uc002unb.2	-	46	10959	c.10735A>G	c.(10735-10737)AGG>GGG	p.R3579G	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTAGTAACCTATAACTTCCA	0.373													3	129					0	0	0	0	C	179616392	C	C	179616392	3	2	226	1	0	0	0	0	1	0	0	0	16803	1521	53	5	99562	5	TTN	2	179616392	Missense_Mutation	SNP	T	TCGA-CV-7104-01A-11D-2012-08	23905095	179616392	63582981	19	41364											
PARD3B	117583	broad.mit.edu	37	chr2	206265816	206265816	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggtggcctgagagaagaaGagctggagaaaatgaaagaa	18	5	15	3	0	0	7	0	2	0	5	0	9	0	7	1	3	1	1	1	3	6	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr2:206265816G>C	uc002var.1	+	19	2917	c.2710G>C	c.(2710-2712)GAG>CAG	p.E904Q	PARD3B_uc002vao.1_Missense_Mutation_p.E904Q|PARD3B_uc002vap.1_Missense_Mutation_p.E842Q|PARD3B_uc002vaq.1_Missense_Mutation_p.E835Q	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	904					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GAGAGAAGAAGAGCTGGAGAA	0.428													3	13					0	0	0	0	C	206265816	C	C	206265816	3	2	226	1	0	0	0	0	1	0	0	0	11498	943	33	2	2784	2	PARD3B	2	206265816	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	26649424	206265816	36933557	20	41365											
MAP2	4133	broad.mit.edu	37	chr2	210518097	210518097	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggtcacagggcacctattCaaataccaaagagaatggga	15	7	11	8	0	2	1	2	0	0	1	2	3	2	2	2	3	1	1	2	3	5	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr2:210518097C>G	uc002vde.1	+	4	451	c.203C>G	c.(202-204)TCA>TGA	p.S68*	MAP2_uc002vdc.1_Nonsense_Mutation_p.S68*|MAP2_uc002vdd.1_Nonsense_Mutation_p.S68*|MAP2_uc002vdf.1_Nonsense_Mutation_p.S68*|MAP2_uc002vdg.1_Nonsense_Mutation_p.S68*|MAP2_uc002vdh.1_Nonsense_Mutation_p.S68*|MAP2_uc002vdi.1_Nonsense_Mutation_p.S68*	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	68					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GGCACCTATTCAAATACCAAA	0.532													23	52					0	0	0	0	G	210518097	G	G	210518097	4	3	226	1	0	0	0	0	0	1	0	0	9288	838	29	2	205	2	MAP2	2	210518097	Nonsense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	4252281	210518097	32681276	21	41366											
TATDN2	9797	broad.mit.edu	37	chr3	10291089	10291089	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgtggcttgctcgcggaggTtatcctggggctcatcccgc	4	11	14	12	3	1	0	1	0	0	0	4	1	3	1	2	5	1	4	2	5	1	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr3:10291089T>G	uc003bvg.2	+	2	786	c.205T>G	c.(205-207)TTA>GTA	p.L69V	TATDN2_uc003bvf.2_Missense_Mutation_p.L69V|TATDN2_uc011atr.1_Missense_Mutation_p.L69V|TATDN2_uc011ats.1_RNA|TATDN2_uc011att.1_RNA	NM_014760	NP_055575	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	69						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			pancreas(2)	2						CTCGCGGAGGTTATCCTGGGG	0.652													7	104					0	0	0	0	G	10291089	G	G	10291089	3	3	226	1	0	0	0	0	1	0	0	0	15658	1722	60	5	207	5	TATDN2	3	10291089	Missense_Mutation	SNP	T	TCGA-CV-7104-01A-11D-2012-08		10291089	187731341	22	41367											
HYAL2	8692	broad.mit.edu	37	chr3	50356381	50356389	+	Splice_Site	DEL	GCTTACCGT	-	-																															gctctggcaggctgggtctcGcttaccgtgcttgtggtgta																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr3:50356381_50356389delGCTTACCGT	uc003czu.2	-	3	1231	c.1011_splice	c.e3+1	p.T337_splice	HYAL2_uc003czx.2_Splice_Site_p.T337_splice|HYAL2_uc003czv.2_Splice_Site_p.T337_splice|HYAL2_uc003czw.2_Splice_Site_p.T337_splice|HYAL2_uc010hlj.2_In_Frame_Del_p.TVS337del	NM_033158	NP_149348	Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2 precursor							anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	GCTGGGTCTCGCTTACCGTGCTTGTGGTG	0.584													---	---	---								-	50356389	-	-	50356381	8	5	226	1	0	1	0	1	0	0	1	0	7503	1102	38	0		0	HYAL2	3	50356381	Splice_Site	DEL	GCTTACCGT	TCGA-CV-7104-01A-11D-2012-08	40065292	50356381	147666049	23	41368											
DNAJC13	23317	broad.mit.edu	37	chr3	132166224	132166224	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggacaaggaacggagttCaacctcacatttcgtaaagg	16	7	10	8	2	2	0	2	0	0	0	3	3	2	3	1	4	2	2	1	4	6	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr3:132166224C>T	uc003eor.2	+	4	269	c.204C>T	c.(202-204)TTC>TTT	p.F68F	DNAJC13_uc010htq.1_Silent_p.F68F	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	68							heat shock protein binding			ovary(1)|breast(1)	2						GAACGGAGTTCAACCTCACAT	0.368													13	69					0	0	0	0	T	132166224	T	T	132166224	2	4	226	1	0	0	0	0	0	0	0	1	4654	825	29	2		2	DNAJC13	3	132166224	Silent	SNP	C	TCGA-CV-7104-01A-11D-2012-08	81809843	132166224	65856206	24	41369											
GFM1	85476	broad.mit.edu	37	chr3	158363475	158363475	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgattcctaatgaaaaaataCgaaatattggaatctcagct	17	12	6	6	1	1	2	1	2	1	0	3	4	2	3	1	1	2	1	1	1	8	5	rs119470019		TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr3:158363475C>T	uc003fce.2	+	2	246	c.139C>T	c.(139-141)CGA>TGA	p.R47*	GFM1_uc003fcd.2_Nonsense_Mutation_p.R47*|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_5'Flank	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	47					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TGAAAAAATACGAAATATTGG	0.383													27	53					0	0	0	0	T	158363475	T	T	158363475	4	4	226	1	0	0	0	0	0	1	0	0	6378	528	19	1	145	1	GFM1	3	158363475	Nonsense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	26197251	158363475	39658955	25	41370											
SERPINI2	5276	broad.mit.edu	37	chr3	167183380	167183380	+	Missense_Mutation	SNP	C	A	A																															tgaatttctgtttccaatctCctttgaaataaatagcattc																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr3:167183380C>A	uc003fer.1	-	3	618	c.560G>T	c.(559-561)GGA>GTA	p.G187V	SERPINI2_uc003fes.1_Missense_Mutation_p.G197V|SERPINI2_uc003fet.1_Missense_Mutation_p.G187V	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	187					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						TTTCCAATCTCCTTTGAAATA	0.388													15	35					3.27435e-08	1.81666e-07	1	0	A	167183380	A	A	167183380	3	1	226	1	0	0	0	0	1	0	0	0	14184	855	30	2	681	2	SERPINI2	3	167183380	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	8819905	167183380	30839050	26	41371	86	2									
SERPINI2	5276	broad.mit.edu	37	chr3	167183382	167183382	+	Silent	SNP	T	C	C																															aatttctgtttccaatctccTttgaaataaatagcattcac																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr3:167183382T>C	uc003fer.1	-	3	616	c.558A>G	c.(556-558)AAA>AAG	p.K186K	SERPINI2_uc003fes.1_Silent_p.K196K|SERPINI2_uc003fet.1_Silent_p.K186K	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	186					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						TCCAATCTCCTTTGAAATAAA	0.393													16	34					0	0	0	0	C	167183382	C	C	167183382	2	2	226	1	0	0	0	0	0	0	0	1	14184	1606	56	5		5	SERPINI2	3	167183382	Silent	SNP	T	TCGA-CV-7104-01A-11D-2012-08	2	167183382	30839048	27	41372	86	2									
MECOM	2122	broad.mit.edu	37	chr3	168838947	168838947	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgcatgggcccgggcaccGacatgctgagagcgaatgtg	9	6	15	11	3	0	1	0	1	0	1	0	4	0	1	2	2	3	3	2	2	1	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr3:168838947G>T	uc003ffi.3	-	6	734	c.465C>A	c.(463-465)GTC>GTA	p.V155V	MECOM_uc010hwk.1_Silent_p.V178V|MECOM_uc003ffj.3_Silent_p.V220V|MECOM_uc011bpi.1_Silent_p.V156V|MECOM_uc003ffn.3_Silent_p.V155V|MECOM_uc003ffk.2_Silent_p.V155V|MECOM_uc003ffl.2_Silent_p.V315V|MECOM_uc011bpj.1_Silent_p.V343V|MECOM_uc011bpk.1_Silent_p.V145V|MECOM_uc010hwn.2_Silent_p.V343V	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	155	Interaction with MAPK9, SMAD3 and probably SUV39H1.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CCCGGGCACCGACATGCTGAG	0.522													16	42					9.16793e-09	5.12446e-08	1	0	T	168838947	T	T	168838947	2	4	226	1	0	0	0	0	0	0	0	1	9475	1045	37	3		3	MECOM	3	168838947	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	1655565	168838947	29183483	28	41373											
CHRD	8646	broad.mit.edu	37	chr3	184104380	184104380	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccggatacagcctctgctgCgccgcctgtggtgcctggtc	3	10	13	15	3	1	0	0	0	1	0	3	1	2	1	5	3	5	1	5	3	1	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr3:184104380C>T	uc003fov.2	+	16	2279	c.2033C>T	c.(2032-2034)GCG>GTG	p.A678V	CHRD_uc003fow.2_Missense_Mutation_p.A308V|CHRD_uc003fox.2_Missense_Mutation_p.A678V|CHRD_uc003foy.2_Missense_Mutation_p.A308V|CHRD_uc010hyc.2_Missense_Mutation_p.A268V|CHRD_uc011brr.1_Intron	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	678					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCCTCTGCTGCGCCGCCTGTG	0.711													5	17					0	0	0	0	T	184104380	T	T	184104380	3	4	226	1	0	0	0	0	1	0	0	0	3387	768	27	1	2095	1	CHRD	3	184104380	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	15265433	184104380	13918050	29	41374											
NCBP2	22916	broad.mit.edu	37	chr3	196664503	196664503	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgcatggcgttttccgcatCtgcgcgtgagtaatatctta	7	13	10	11	5	2	1	0	1	2	0	3	1	3	1	2	1	1	4	2	1	3	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr3:196664503C>G	uc003fxd.1	-	3	367	c.277G>C	c.(277-279)GAT>CAT	p.D93H	NCBP2_uc003fxb.1_Missense_Mutation_p.D23H|NCBP2_uc011btz.1_Missense_Mutation_p.D75H|NCBP2_uc003fxc.1_RNA|NCBP2_uc003fxe.1_Splice_Site_p.Y40_splice|NCBP2_uc003fxf.2_3'UTR	NM_007362	NP_031388	P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	93	RRM.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding				0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		TTTTCCGCATCTGCGCGTGAG	0.448													21	77					0	0	0	0	G	196664503	G	G	196664503	3	3	226	1	0	0	0	0	1	0	0	0	10266	927	32	2	201	2	NCBP2	3	196664503	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	12560123	196664503	1357927	30	41375											
MFSD10	10227	broad.mit.edu	37	chr4	2934445	2934445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggaaggccgcaaagctcCgagaggtggcccagactgca	11	3	14	13	2	0	2	0	0	0	2	1	4	1	3	4	4	2	3	4	4	2	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr4:2934445C>T	uc003gfw.2	-	4	727	c.413G>A	c.(412-414)CGG>CAG	p.R138Q	MFSD10_uc003gfv.2_5'Flank|MFSD10_uc003gfx.2_Intron|MFSD10_uc003gfz.2_Missense_Mutation_p.R138Q|MFSD10_uc003gfy.2_RNA|MFSD10_uc003gga.2_Missense_Mutation_p.R138Q|MFSD10_uc003ggb.1_Missense_Mutation_p.R138Q|MFSD10_uc003ggc.2_Missense_Mutation_p.R138Q|C4orf10_uc003ggd.1_5'Flank|C4orf10_uc003gge.1_5'Flank|C4orf10_uc003ggg.1_5'Flank|C4orf10_uc003ggh.2_5'Flank	NM_001120	NP_001111	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing	138					apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CGCAAAGCTCCGAGAGGTGGC	0.652													15	64					0	0	0	0	T	2934445	T	T	2934445	3	4	226	1	0	0	0	0	1	0	0	0	9581	652	23	1	990	1	MFSD10	4	2934445	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08		2934445	188219831	31	41376											
ATP8A1	10396	broad.mit.edu	37	chr4	42445599	42445599	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tacctctcctgacatatcagGggccatcggaatggcaggcc	9	8	11	13	1	2	1	1	1	1	0	4	2	2	2	4	5	1	1	4	5	3	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr4:42445599G>T	uc003gwr.2	-	33	3338	c.3106C>A	c.(3106-3108)CCT>ACT	p.P1036T	ATP8A1_uc003gwq.2_Missense_Mutation_p.P262T|ATP8A1_uc003gws.2_Missense_Mutation_p.P1021T	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	1036	Extracellular (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	GACATATCAGGGGCCATCGGA	0.433													11	28					4.36969e-10	2.47947e-09	1	0	T	42445599	T	T	42445599	3	4	226	1	0	0	0	0	1	0	0	0	1194	1232	43	4	408	4	ATP8A1	4	42445599	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	39511154	42445599	148708677	32	41377											
CORIN	10699	broad.mit.edu	37	chr4	47605597	47605597	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggggatgcaggatgatggTcttcacaaagcgtgtctgca	9	9	15	8	2	3	1	1	1	2	0	3	3	3	3	0	4	3	2	0	4	1	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr4:47605597T>C	uc003gxm.2	-	20	2722	c.2629A>G	c.(2629-2631)ACC>GCC	p.T877A	CORIN_uc011bzf.1_Missense_Mutation_p.T738A|CORIN_uc011bzg.1_Missense_Mutation_p.T810A	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	877	Extracellular (Potential).|Peptidase S1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						AGGATGATGGTCTTCACAAAG	0.488													3	50					0	0	0	0	C	47605597	C	C	47605597	3	2	226	1	0	0	0	0	1	0	0	0	3767	1667	58	5	511	5	CORIN	4	47605597	Missense_Mutation	SNP	T	TCGA-CV-7104-01A-11D-2012-08	5159998	47605597	143548679	33	41378											
ADCY2	108	broad.mit.edu	37	chr5	7396480	7396480	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcggcgggcggcggagAcgggctgccgcggtcccggg	3	2	24	12	8	0	1	0	0	0	1	1	3	1	2	2	9	1	1	2	9	0	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr5:7396480A>T	uc003jdz.1	+	1	138	c.71A>T	c.(70-72)GAC>GTC	p.D24V		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	24	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGCGGCGGAGACGGGCTGCCG	0.652													16	22					0	0	0	0	T	7396480	T	T	7396480	3	4	226	1	0	0	0	0	1	0	0	0	294	275	10	5	73	5	ADCY2	5	7396480	Missense_Mutation	SNP	A	TCGA-CV-7104-01A-11D-2012-08		7396480	173518780	34	41379											
CDH12	1010	broad.mit.edu	37	chr5	21752115	21752115	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtctgtgttatcttccatggGtggtctctgacgaggtaaac	7	14	12	8	1	3	1	0	1	3	0	5	2	4	1	1	3	1	2	1	3	3	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr5:21752115G>T	uc010iuc.2	-	12	2574	c.2116C>A	c.(2116-2118)CCC>ACC	p.P706T	CDH12_uc011cno.1_Missense_Mutation_p.P666T|CDH12_uc003jgk.2_Missense_Mutation_p.P706T|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	706	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TCTTCCATGGGTGGTCTCTGA	0.448										HNSCC(59;0.17)			23	92					1.64293e-13	9.68943e-13	1	0	T	21752115	T	T	21752115	3	4	226	1	0	0	0	0	1	0	0	0	3113	1261	44	4	272	4	CDH12	5	21752115	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	14355635	21752115	159163145	35	41380											
CDH9	1007	broad.mit.edu	37	chr5	26881690	26881690	+	Frame_Shift_Del	DEL	T	-	-																															ttgaaattatcagaggttccTtttttctttgcctcttcaat																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr5:26881690delT	uc003jgs.1	-	12	2094	c.1925delA	c.(1924-1926)AAGfs	p.K642fs	CDH9_uc011cnv.1_Frame_Shift_Del_p.K235fs	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	642	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CAGAGGTTCCTTTTTTCTTTG	0.398													---	---	---								-	26881690	-	-	26881690	7	5	226	1	0	1	0	1	0	0	0	0	3132	1609	56	0	448	0	CDH9	5	26881690	Frame_Shift_Del	DEL	T	TCGA-CV-7104-01A-11D-2012-08	5129575	26881690	154033570	36	41381											
ADAMTS12	81792	broad.mit.edu	37	chr5	33576387	33576387	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtctcctcccagagggagCagagtgttggctggcttttc	5	12	14	10	0	1	2	0	0	1	2	4	3	2	3	2	4	1	4	2	4	0	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr5:33576387C>A	uc003jia.1	-	19	3907	c.3744G>T	c.(3742-3744)CTG>CTT	p.L1248L	ADAMTS12_uc010iuq.1_Silent_p.L1163L	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1248	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CCAGAGGGAGCAGAGTGTTGG	0.522										HNSCC(64;0.19)			56	177					1.46156e-29	9.27717e-29	1	0	A	33576387	A	A	33576387	2	1	226	1	0	0	0	0	0	0	0	1	257	697	25	4		4	ADAMTS12	5	33576387	Silent	SNP	C	TCGA-CV-7104-01A-11D-2012-08	6694697	33576387	147338873	37	41382											
UGT3A2	167127	broad.mit.edu	37	chr5	36066838	36066838	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attttggcagcctctgagagCaggaccccagggagaaggaa	12	6	14	9	0	1	2	0	1	1	2	1	6	1	4	3	4	2	2	3	4	2	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr5:36066838C>A	uc003jjz.1	-	1	147	c.54G>T	c.(52-54)CTG>CTT	p.L18L	UGT3A2_uc011cos.1_Silent_p.L18L|UGT3A2_uc011cot.1_5'UTR	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	18						integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCTCTGAGAGCAGGACCCCAG	0.607													97	131					3.57987e-33	2.29173e-32	1	0	A	36066838	A	A	36066838	2	1	226	1	0	0	0	0	0	0	0	1	17032	697	25	4		4	UGT3A2	5	36066838	Silent	SNP	C	TCGA-CV-7104-01A-11D-2012-08	2490451	36066838	144848422	38	41383											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139781714	139781714	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggaggccgggccagcgtcGggagtcggcagcagcggcgg	5	2	23	11	6	0	0	0	0	0	0	2	2	0	2	2	8	3	2	2	8	0	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr5:139781714G>A	uc003lfs.1	+	1	286	c.162G>A	c.(160-162)TCG>TCA	p.S54S	ANKHD1_uc003lfq.1_Silent_p.S54S|ANKHD1_uc003lfr.2_Silent_p.S54S|uc003lfn.2_5'Flank|ANKHD1_uc003lfp.2_Silent_p.S54S|ANKHD1_uc003lfo.2_Silent_p.S54S|ANKHD1_uc010jfk.2_Silent_p.S54S	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	54						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCAGCGTCGGGAGTcggca	0.622													16	9					0	0	0	0	A	139781714	A	A	139781714	2	1	226	1	0	0	0	0	0	0	0	1	629	1103	39	1		1	ANKHD1-EIF4EBP3	5	139781714	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	103714876	139781714	41133546	39	41384											
PCDHGB6	56100	broad.mit.edu	37	chr5	140789785	140789785	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaacttgcaagagatactGccagacctcagcgaccgccc	12	5	9	15	2	1	2	1	0	0	2	1	5	1	2	4	0	5	1	4	0	3	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr5:140789785G>A	uc003lkj.1	+	1	2016	c.2016G>A	c.(2014-2016)CTG>CTA	p.L672L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.L672L|PCDHGA10_uc011day.1_5'Flank|PCDHGA10_uc003lkl.1_5'Flank	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	672	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAGATACTGCCAGACCTCA	0.607													66	54					0	0	0	0	A	140789785	A	A	140789785	2	1	226	1	0	0	0	0	0	0	0	1	11621	1306	46	4		4	PCDHGB6	5	140789785	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	1008071	140789785	40125475	40	41385											
NR3C1	2908	broad.mit.edu	37	chr5	142675046	142675046	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaagagagaagcagtaaggTtttcatacagagatactctt	15	11	10	5	0	2	4	1	1	1	3	2	6	2	4	0	1	3	3	0	1	5	6			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr5:142675046T>G	uc003lmz.2	-	7	2494	c.2002A>C	c.(2002-2004)ACC>CCC	p.T668P	NR3C1_uc003lmy.2_Missense_Mutation_p.T669P|NR3C1_uc003lna.2_Missense_Mutation_p.T668P|NR3C1_uc003lnb.2_Missense_Mutation_p.T668P|NR3C1_uc011dbk.1_Missense_Mutation_p.T271P|NR3C1_uc003lnc.2_Missense_Mutation_p.T668P|NR3C1_uc003lnd.2_Missense_Mutation_p.T668P|NR3C1_uc003lne.2_Missense_Mutation_p.T668P|NR3C1_uc003lnf.2_Missense_Mutation_p.T669P	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	668	Steroid-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	AGCAGTAAGGTTTTCATACAG	0.378													9	38					0	0	0	0	G	142675046	G	G	142675046	3	3	226	1	0	0	0	0	1	0	0	0	10684	1725	60	5	395	5	NR3C1	5	142675046	Missense_Mutation	SNP	T	TCGA-CV-7104-01A-11D-2012-08	1885261	142675046	38240214	41	41386											
FAT2	2196	broad.mit.edu	37	chr5	150929062	150929062	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgataggtatttcctggtctCggacctatgggcccaaaggg	8	11	13	9	1	1	1	0	1	1	0	3	2	2	2	3	5	0	1	3	5	4	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr5:150929062C>T	uc003lue.3	-	8	4596	c.4583G>A	c.(4582-4584)CGA>CAA	p.R1528Q	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1528	Extracellular (Potential).|Cadherin 13.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCCTGGTCTCGGACCTATGG	0.483													26	12					0	0	0	0	T	150929062	T	T	150929062	3	4	226	1	0	0	0	0	1	0	0	0	5722	884	31	1	8530	1	FAT2	5	150929062	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	8254016	150929062	29986198	42	41387											
WWC1	23286	broad.mit.edu	37	chr5	167850580	167850580	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcctcaggcagcagcccCggatccctcacgtccagccg	6	6	10	19	3	2	0	2	0	0	0	5	1	5	1	6	2	3	2	6	2	0	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr5:167850580C>G	uc003lzu.2	+	11	1410	c.1317C>G	c.(1315-1317)CCC>CCG	p.P439P	WWC1_uc003lzv.2_Silent_p.P439P|WWC1_uc011den.1_Silent_p.P439P|WWC1_uc003lzw.2_Silent_p.P238P	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	439					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GCAGCAGCCCCGGATCCCTCA	0.617													32	111					0	0	0	0	G	167850580	G	G	167850580	2	3	226	1	0	0	0	0	0	0	0	1	17479	639	23	3		3	WWC1	5	167850580	Silent	SNP	C	TCGA-CV-7104-01A-11D-2012-08	16921518	167850580	13064680	43	41388											
LSM2	57819	broad.mit.edu	37	chr6	31765655	31765655	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatgaagcagttcttcactGataactagacaaagatggac	16	9	9	7	0	2	4	1	2	1	2	2	6	2	5	0	1	2	2	0	1	5	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr6:31765655G>A	uc003nxg.2	-	5	376	c.167C>T	c.(166-168)TCA>TTA	p.S56L	VARS_uc003nxe.2_5'Flank|VARS_uc011doi.1_5'Flank	NM_021177	NP_067000	Q9Y333	LSM2_HUMAN	LSM2 homolog, U6 small nuclear RNA associated	56					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytosol|nucleoplasm	U6 snRNA binding				0						GTTCTTCACTGATAACTAGAC	0.493													47	154					0	0	0	0	A	31765655	A	A	31765655	3	1	226	1	0	0	0	0	1	0	0	0	9106	1294	45	2	124	2	LSM2	6	31765655	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08		31765655	139349412	44	41389											
DNAH8	1769	broad.mit.edu	37	chr6	38843598	38843598	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtatgagttttatgttactGattatggtaagcccactgaa	11	16	9	5	0	0	3	0	3	0	0	0	3	0	3	1	1	2	4	1	1	6	6			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr6:38843598G>A	uc003ooe.1	+	51	7801	c.7201G>A	c.(7201-7203)GAT>AAT	p.D2401N		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTATGTTACTGATTATGGTAA	0.328													10	16					0	0	0	0	A	38843598	A	A	38843598	3	1	226	1	0	0	0	0	1	0	0	0	4629	1290	45	2	7395	2	DNAH8	6	38843598	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	7077943	38843598	132271469	45	41390											
ZNF451	26036	broad.mit.edu	37	chr6	56993596	56993596	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcgaggacattctgatacaGaagcagcaagactgtgtgtg	12	10	12	7	1	1	3	0	1	1	2	2	5	1	4	0	1	3	2	0	1	3	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr6:56993596G>A	uc003pdm.1	+	5	606	c.382G>A	c.(382-384)GAA>AAA	p.E128K	ZNF451_uc003pdl.2_Missense_Mutation_p.E128K|ZNF451_uc003pdn.1_Missense_Mutation_p.E128K|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.E128K	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TTCTGATACAGAAGCAGCAAG	0.373													24	48					0	0	0	0	A	56993596	A	A	56993596	3	1	226	1	0	0	0	0	1	0	0	0	17989	943	33	2	400	2	ZNF451	6	56993596	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	18149998	56993596	114121471	46	41391											
SGK1	6446	broad.mit.edu	37	chr6	134495871	134495871	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaagattcctgcactcaccGatgagaattgccaccatgcc	11	8	8	14	1	1	2	1	1	0	2	2	4	2	2	5	0	3	2	5	0	2	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr6:134495871G>A	uc003qen.3	-	1	164	c.75C>T	c.(73-75)ATC>ATT	p.I25I	SGK1_uc003qeo.3_Intron|SGK1_uc011ect.1_5'UTR|SGK1_uc011ecu.1_Silent_p.I25I|SGK1_uc011ecv.1_Intron|SGK1_uc011ecw.1_Intron	NM_005627	NP_005618	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1 isoform	25	Necessary for localization to the cytoplasm.				apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(3)|stomach(1)|lung(1)|central_nervous_system(1)	6	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		TGCACTCACCGATGAGAATTG	0.542											OREG0017675	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	113					0	0	0	0	A	134495871	A	A	134495871	2	1	226	1	0	0	0	0	0	0	0	1	14272	1072	37	1		1	SGK1	6	134495871	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	77502275	134495871	36619196	47	41392											
TARP	445347	broad.mit.edu	37	chr7	38357071	38357071	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccaaggactgccagcgttGatgtgtggagcagtgacagc	9	7	14	11	1	0	2	0	2	0	0	0	4	0	4	3	2	4	2	3	2	1	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr7:38357071G>C	uc003tge.1	-	2	400	c.23C>G	c.(22-24)TCA>TGA	p.S8*	uc003tfz.1_5'Flank|TARP_uc003tgf.1_5'Flank|TARP_uc003tgj.1_5'Flank|TARP_uc003tgh.1_5'Flank|TARP_uc003tgi.1_5'Flank|TARP_uc003tgg.1_5'Flank			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						TGCCAGCGTTGATGTGTGGAG	0.468													4	12					0	0	0	0	C	38357071	C	C	38357071	4	2	226	1	0	0	0	0	0	1	0	0	15624	1305	45	2		2	TARP	7	38357071	Nonsense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08		38357071	120781592	48	41393											
BAZ1B	9031	broad.mit.edu	37	chr7	72884760	72884760	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcctggaaagctttctcagCagctgctttgtgcttccgta	6	15	9	11	1	1	0	1	0	1	0	4	1	3	1	2	1	5	6	2	1	2	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr7:72884760C>A	uc003tyc.2	-	8	2992	c.2647G>T	c.(2647-2649)GCT>TCT	p.A883S		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	883	Potential.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				GCTTTCTCAGCAGCTGCTTTG	0.428													34	55					3.11337e-16	1.89587e-15	1	0	A	72884760	A	A	72884760	3	1	226	1	0	0	0	0	1	0	0	0	1332	710	25	4	1852	4	BAZ1B	7	72884760	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	34527689	72884760	86253903	49	41394											
TAS2R38	5726	broad.mit.edu	37	chr7	141673457	141673457	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatgtactcctgacttcataGgacacagtgcggatgcgagt	11	10	11	9	2	1	1	1	1	0	0	2	4	2	3	1	2	3	1	1	2	3	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr7:141673457G>C	uc003vwx.1	-	1	117	c.33C>G	c.(31-33)TCC>TCG	p.S11S		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	11	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					TGACTTCATAGGACACAGTGC	0.433													19	68					0	0	0	0	C	141673457	C	C	141673457	2	2	226	1	0	0	0	0	0	0	0	1	15641	987	35	4		4	TAS2R38	7	141673457	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	68788697	141673457	17465206	50	41395											
ARHGEF5	7984	broad.mit.edu	37	chr7	144075958	144075958	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgactcagcagagcagtgaCggtaagcgggagcatgcgtg	10	6	17	8	3	1	3	1	2	0	1	1	4	1	4	0	2	5	4	0	2	1	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr7:144075958C>A	uc003wel.2	+	14	4753	c.4635C>A	c.(4633-4635)GAC>GAA	p.D1545E	ARHGEF5_uc003wem.2_Missense_Mutation_p.D346E	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1545	SH3.				intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					AGAGCAGTGACGGTAAGCGGG	0.493													35	96					6.84511e-11	3.91373e-10	1	0	A	144075958	A	A	144075958	3	1	226	1	0	0	0	0	1	0	0	0	909	550	19	3	4685	3	ARHGEF5	7	144075958	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	2402501	144075958	15062705	51	41396											
NOS3	4846	broad.mit.edu	37	chr7	150693876	150693876	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctcccaggcccacgaacagCggcttcaagaggtggaagcc	10	4	13	14	2	1	1	1	0	0	1	2	3	2	2	3	4	3	2	3	4	3	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr7:150693876C>T	uc003wif.2	+	5	741	c.445C>T	c.(445-447)CGG>TGG	p.R149W	NOS3_uc011kuy.1_Intron|NOS3_uc011kuz.1_Missense_Mutation_p.R149W|NOS3_uc011kva.1_Missense_Mutation_p.R149W|NOS3_uc011kvb.1_Missense_Mutation_p.R149W	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	149	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCACGAACAGCGGCTTCAAGA	0.657													5	21					0	0	0	0	T	150693876	T	T	150693876	3	4	226	1	0	0	0	0	1	0	0	0	10598	759	27	1	459	1	NOS3	7	150693876	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	6617918	150693876	8444787	52	41397											
ZNF596	169270	broad.mit.edu	37	chr8	196070	196070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaatcttctgacctcagacGacatgagagaactcacactg	13	9	8	11	1	4	5	2	3	2	2	4	7	4	5	1	0	1	0	1	0	2	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr8:196070G>A	uc003wot.2	+	6	1511	c.1223G>A	c.(1222-1224)CGA>CAA	p.R408Q	ZNF596_uc003wou.2_Missense_Mutation_p.R307Q|ZNF596_uc003wov.2_Missense_Mutation_p.R408Q|ZNF596_uc003wow.2_Missense_Mutation_p.R408Q	NM_173539	NP_775810	Q8TC21	ZN596_HUMAN	zinc finger protein 596	408	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)		GACCTCAGACGACATGAGAGA	0.438													20	38					0	0	0	0	A	196070	A	A	196070	3	1	226	1	0	0	0	0	1	0	0	0	18093	1058	37	1	1241	1	ZNF596	8	196070	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08		196070	146167952	53	41398											
SDCBP	6386	broad.mit.edu	37	chr8	59494271	59494271	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accaagcattatgaaaagccTaatggaccacaccattcctg	15	8	6	12	0	0	1	0	1	0	0	1	2	1	2	5	1	2	1	5	1	5	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr8:59494271T>C	uc003xtn.2	+	9	1019	c.869T>C	c.(868-870)CTA>CCA	p.L290P	SDCBP_uc003xto.2_Missense_Mutation_p.L289P|SDCBP_uc003xtr.2_Missense_Mutation_p.L289P|SDCBP_uc003xtp.2_Missense_Mutation_p.L284P|SDCBP_uc003xtq.2_Missense_Mutation_p.L290P|SDCBP_uc003xts.2_Missense_Mutation_p.L296P|SDCBP_uc011led.1_Missense_Mutation_p.L231P	NM_005625	NP_005616	O00560	SDCB1_HUMAN	syntenin isoform 1	290					actin cytoskeleton organization|axon guidance|positive regulation of phosphorylation|protein targeting to membrane|substrate-dependent cell migration, cell extension|synaptic transmission	cytoskeleton|cytosol|endoplasmic reticulum membrane|focal adhesion|interleukin-5 receptor complex|melanosome|nucleus	cytoskeletal adaptor activity|frizzled binding|interleukin-5 receptor binding|protein heterodimerization activity|protein N-terminus binding|syndecan binding				0		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				ATGAAAAGCCTAATGGACCAC	0.388													3	129					0	0	0	0	C	59494271	C	C	59494271	3	2	226	1	0	0	0	0	1	0	0	0	14020	1522	53	5	899	5	SDCBP	8	59494271	Missense_Mutation	SNP	T	TCGA-CV-7104-01A-11D-2012-08	59298201	59494271	86869751	54	41399											
ARMC1	55156	broad.mit.edu	37	chr8	66539564	66539564	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttaacggatctgctgctaGatcccgtaactggttaacta	10	13	9	9	2	1	1	0	0	1	1	2	2	2	2	1	2	5	5	1	2	5	6			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr8:66539564G>C	uc003xvl.2	-	2	305	c.70C>G	c.(70-72)CTA>GTA	p.L24V	ARMC1_uc011leo.1_Translation_Start_Site	NM_018120	NP_060590	Q9NVT9	ARMC1_HUMAN	armadillo repeat-containing protein	24					metal ion transport		metal ion binding			skin(1)	1			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			TCTGCTGCTAGATCCCGTAAC	0.463													32	168					0	0	0	0	C	66539564	C	C	66539564	3	2	226	1	0	0	0	0	1	0	0	0	951	933	33	2	802	2	ARMC1	8	66539564	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	7045293	66539564	79824458	55	41400											
SULF1	23213	broad.mit.edu	37	chr8	70570762	70570762	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gacagttatgggatggatggGaaggttaatcagccccgtct	10	10	14	7	1	2	0	1	0	1	0	2	4	2	3	2	4	1	2	2	4	3	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr8:70570762G>T	uc010lza.1	+	23	3325	c.2608G>T	c.(2608-2610)GAA>TAA	p.E870*	SULF1_uc003xyd.2_Nonsense_Mutation_p.E870*|SULF1_uc003xye.2_Nonsense_Mutation_p.E870*|SULF1_uc003xyf.2_Nonsense_Mutation_p.E870*|SULF1_uc003xyg.2_Nonsense_Mutation_p.E870*|SULF1_uc003xyh.1_RNA|SULF1_uc003xyi.1_Silent_p.G16G|SULF1_uc003xyj.1_Silent_p.G16G	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	870					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GGATGGATGGGAAGGTTAATC	0.433													40	45					8.04919e-23	5.06625e-22	1	0	T	70570762	T	T	70570762	4	4	226	1	0	0	0	0	0	1	0	0	15436	1175	41	2	2682	2	SULF1	8	70570762	Nonsense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	4031198	70570762	75793260	56	41401											
LRRCC1	85444	broad.mit.edu	37	chr8	86035688	86035688	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgttcttgagaaagaccccaGaccaaaaagagacacagata	18	5	8	10	1	1	5	0	1	1	5	1	7	1	5	3	0	0	1	3	0	4	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr8:86035688G>A	uc003ycw.2	+	7	1125	c.971G>A	c.(970-972)AGA>AAA	p.R324K	LRRCC1_uc010lzz.1_Intron|LRRCC1_uc010maa.1_Missense_Mutation_p.R25K|LRRCC1_uc003ycx.2_Missense_Mutation_p.R231K|LRRCC1_uc003ycy.2_Missense_Mutation_p.R304K	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	324					cell division|mitosis	centriole|nucleus					0						AAAGACCCCAGACCAAAAAGA	0.308													4	155					0	0	0	0	A	86035688	A	A	86035688	3	1	226	1	0	0	0	0	1	0	0	0	9076	942	33	2	997	2	LRRCC1	8	86035688	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	15464926	86035688	60328334	57	41402											
ESRP1	54845	broad.mit.edu	37	chr8	95677422	95677423	+	Missense_Mutation	DNP	GT	TA	TA																															agatttccttaaaattgctgGtggtaagtgccttttacata																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr8:95677422_95677423GT>TA	uc003ygq.3	+	9	1112_1113	c.929_930GT>TA	c.(928-930)GGT>GTA	p.G310V	ESRP1_uc003ygr.3_Missense_Mutation_p.G310V|ESRP1_uc003ygs.3_Missense_Mutation_p.G310V|ESRP1_uc003ygt.3_Missense_Mutation_p.G310V|ESRP1_uc003ygu.3_Missense_Mutation_p.G310V|ESRP1_uc003ygv.2_Missense_Mutation_p.G150V|ESRP1_uc003ygw.2_Missense_Mutation_p.G150V	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	310					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						AAAATTGCTGGTGGTAAGTGCC	0.347													9	26					0	0	0	0	TA	95677423	TA	TA	95677422	3	4	226	1	0	0	0	0	1	0	0	0	5282	1261	44	4	963	4	ESRP1	8	95677422	Missense_Mutation	DNP	GT	TCGA-CV-7104-01A-11D-2012-08	9641734	95677422	50686600	58	41403											
TRPS1	7227	broad.mit.edu	37	chr8	116631947	116631947	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccccagcagctggagatgaGaaagccaacatatttctgtc	12	8	9	12	0	1	2	0	1	1	2	2	4	1	2	3	1	4	2	3	1	3	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr8:116631947G>C	uc003ynz.2	-	2	798	c.339C>G	c.(337-339)TTC>TTG	p.F113L	TRPS1_uc011lhy.1_Missense_Mutation_p.F117L|TRPS1_uc003yny.2_Missense_Mutation_p.F126L|TRPS1_uc010mcy.2_Missense_Mutation_p.F113L	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	113					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTGGAGATGAGAAAGCCAACA	0.527									Langer-Giedion_syndrome				28	116					0	0	0	0	C	116631947	C	C	116631947	3	2	226	1	0	0	0	0	1	0	0	0	16660	933	33	2	3526	2	TRPS1	8	116631947	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	20954525	116631947	29732075	59	41404											
RECQL4	9401	broad.mit.edu	37	chr8	145737407	145737407	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcctggtgctgcgctcctCatcctgctgctccaggcagg	4	9	13	15	1	1	0	1	0	0	0	4	1	4	0	4	3	5	5	4	3	0	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr8:145737407C>T	uc003zdj.2	-	20	3312	c.3280G>A	c.(3280-3282)GAG>AAG	p.E1094K		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	1094					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CTGCGCTCCTCATCCTGCTGC	0.682			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				5	29					0	0	0	0	T	145737407	T	T	145737407	3	4	226	1	0	0	0	0	1	0	0	0	13267	835	29	2	358	2	RECQL4	8	145737407	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	29105460	145737407	626615	60	41405											
TAF1L	138474	broad.mit.edu	37	chr9	32633291	32633291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcacgaaaaaggttgttctCaagtgcctgcagtaattggc	12	10	11	8	1	1	0	1	0	1	0	2	1	1	0	1	2	3	5	1	2	4	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr9:32633291C>T	uc003zrg.1	-	1	2377	c.2287G>A	c.(2287-2289)GAG>AAG	p.E763K	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	763					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGGTTGTTCTCAAGTGCCTGC	0.433													8	99					0	0	0	0	T	32633291	T	T	32633291	3	4	226	1	0	0	0	0	1	0	0	0	15589	835	29	2	3197	2	TAF1L	9	32633291	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08		32633291	108580140	61	41406											
APBA1	320	broad.mit.edu	37	chr9	72047505	72047505	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctcgtggggggtggccaCgacgctctgtccattgattt	4	13	13	11	3	2	1	0	1	2	0	4	2	3	1	2	4	0	1	2	4	0	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr9:72047505C>T	uc004ahh.2	-	12	2665	c.2389G>A	c.(2389-2391)GTG>ATG	p.V797M		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	797	PDZ 2.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GGGGTGGCCACGACGCTCTGT	0.607													20	38					0	0	0	0	T	72047505	T	T	72047505	3	4	226	1	0	0	0	0	1	0	0	0	756	536	19	1	132	1	APBA1	9	72047505	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	39414214	72047505	69165926	62	41407											
TMEM2	23670	broad.mit.edu	37	chr9	74347385	74347385	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagaattccaacctcagctCtcatgtctacaccgtctatg	11	12	5	13	1	4	1	2	0	3	1	6	1	5	1	3	0	3	1	3	0	5	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr9:74347385C>T	uc011lsa.1	-	7	1985	c.1445G>A	c.(1444-1446)AGA>AAA	p.R482K	TMEM2_uc010mos.2_Missense_Mutation_p.R419K|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	482						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AACCTCAGCTCTCATGTCTAC	0.408													5	38					0	0	0	0	T	74347385	T	T	74347385	3	4	226	1	0	0	0	0	1	0	0	0	16187	913	32	2	2778	2	TMEM2	9	74347385	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	2299880	74347385	66866046	63	41408											
ANKS6	203286	broad.mit.edu	37	chr9	101552849	101552849	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcattgacatcagccccGtgatccaacaggaggtgtgc	9	8	13	11	1	1	2	1	2	0	0	2	3	2	3	3	3	3	1	3	3	1	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr9:101552849G>A	uc004ayu.2	-	2	420	c.399C>T	c.(397-399)CAC>CAT	p.H133H	ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	133	ANK 3.									ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				CATCAGCCCCGTGATCCAACA	0.597													11	29					0	0	0	0	A	101552849	A	A	101552849	2	1	226	1	0	0	0	0	0	0	0	1	692	1136	40	1		1	ANKS6	9	101552849	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	27205464	101552849	39660582	64	41409											
ALG2	85365	broad.mit.edu	37	chr9	101980890	101980890	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggacatcagggtctatgtGagacagggacttgaatgttt	11	11	14	5	0	2	2	1	2	1	1	2	6	2	4	0	3	0	1	0	3	2	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr9:101980890G>C	uc004azf.2	-	2	647	c.577C>G	c.(577-579)CAC>GAC	p.H193D	ALG2_uc004azg.2_Missense_Mutation_p.H100D	NM_033087	NP_149078	Q9H553	ALG2_HUMAN	alpha-1,3-mannosyltransferase ALG2	193					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding	p.H193P(1)		ovary(2)	2		Acute lymphoblastic leukemia(62;0.0559)				GGGTCTATGTGAGACAGGGAC	0.453													13	97					0	0	0	0	C	101980890	C	C	101980890	3	2	226	1	0	0	0	0	1	0	0	0	519	1290	45	2	677	2	ALG2	9	101980890	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	428041	101980890	39232541	65	41410											
AMBP	259	broad.mit.edu	37	chr9	116840403	116840403	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttgaagttttcctgcacttgGatgttgtcgggcggcgttgg	4	15	15	7	3	0	1	0	1	0	0	2	2	1	2	1	4	1	4	1	4	1	6			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr9:116840403G>C	uc004bie.3	-	1	350	c.87C>G	c.(85-87)ATC>ATG	p.I29M	AMBP_uc011lxk.1_5'Flank|AMBP_uc010mvc.1_RNA	NM_001633	NP_001624	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin preproprotein	29					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			skin(1)	1					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	CCTGCACTTGGATGTTGTCGG	0.637													14	105					0	0	0	0	C	116840403	C	C	116840403	3	2	226	1	0	0	0	0	1	0	0	0	564	1164	41	2	1011	2	AMBP	9	116840403	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	14859513	116840403	24373028	66	41411											
OR1N2	138882	broad.mit.edu	37	chr9	125316206	125316206	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atctcctggagggagatggaAggccttctctacctgtggtt	7	12	13	9	0	2	1	0	0	2	1	4	4	2	3	3	5	1	1	3	5	2	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr9:125316206A>C	uc011lyx.1	+	1	758	c.758A>C	c.(757-759)AAG>ACG	p.K253T		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	253	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						GGGAGATGGAAGGCCTTCTCT	0.498													54	125					0	0	0	0	C	125316206	C	C	125316206	3	2	226	1	0	0	0	0	1	0	0	0	11024	72	3	5	760	5	OR1N2	9	125316206	Missense_Mutation	SNP	A	TCGA-CV-7104-01A-11D-2012-08	8475803	125316206	15897225	67	41412											
FAM129B	64855	broad.mit.edu	37	chr9	130269539	130269539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttttccgagagggtggctGactccggggtgctggggctg	3	10	19	9	2	0	2	0	1	0	1	2	3	2	2	2	6	1	4	2	6	0	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr9:130269539G>A	uc004brh.2	-	14	2028	c.1826C>T	c.(1825-1827)TCA>TTA	p.S609L	FAM129B_uc004bri.2_Missense_Mutation_p.S596L|FAM129B_uc004brj.3_3'UTR	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	609							protein binding				0						GAGGGTGGCTGACTCCGGGGT	0.697													5	52					0	0	0	0	A	130269539	A	A	130269539	3	1	226	1	0	0	0	0	1	0	0	0	5465	1294	45	2	418	2	FAM129B	9	130269539	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	4953333	130269539	10943892	68	41413											
FPGS	2356	broad.mit.edu	37	chr9	130572339	130572339	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggttcgagtcttgctcttcaAtgctaccggggaccgggacc	6	10	13	12	3	3	0	1	0	2	0	4	3	3	2	3	4	3	3	3	4	2	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr9:130572339A>G	uc004bsg.1	+	13	1291	c.1241A>G	c.(1240-1242)AAT>AGT	p.N414S	FPGS_uc004bsh.1_Missense_Mutation_p.N231S|FPGS_uc011mal.1_Missense_Mutation_p.N388S|FPGS_uc004bsi.1_Missense_Mutation_p.N364S	NM_004957	NP_004948	Q05932	FOLC_HUMAN	folylpolyglutamate synthase isoform a precursor	414					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity				0					L-Glutamic Acid(DB00142)	TTGCTCTTCAATGCTACCGGG	0.637													8	22					0	0	0	0	G	130572339	G	G	130572339	3	3	226	1	0	0	0	0	1	0	0	0	6070	101	4	5	1291	5	FPGS	9	130572339	Missense_Mutation	SNP	A	TCGA-CV-7104-01A-11D-2012-08	302800	130572339	10641092	69	41414											
RBP3	5949	broad.mit.edu	37	chr10	48388506	48388506	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagagcagcgggatggccGtggagtagctgccagggttg	8	6	19	8	2	0	1	0	0	0	1	0	3	0	3	2	4	5	5	2	4	1	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr10:48388506G>A	uc001jez.2	-	1	2486	c.2372C>T	c.(2371-2373)ACG>ATG	p.T791M		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	791	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CGGGATGGCCGTGGAGTAGCT	0.622													8	17					0	0	0	0	A	48388506	A	A	48388506	3	1	226	1	0	0	0	0	1	0	0	0	13222	1145	40	1	1387	1	RBP3	10	48388506	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08		48388506	87146241	70	41415											
JMJD1C	221037	broad.mit.edu	37	chr10	64966567	64966567	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttcagagccagattcataaGttcttttggcttttctcctg	7	18	7	9	0	4	2	2	0	2	2	5	2	4	2	2	1	1	2	2	1	1	8			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr10:64966567G>A	uc001jmn.2	-	10	5162	c.4862C>T	c.(4861-4863)ACT>ATT	p.T1621I	JMJD1C_uc001jml.2_Missense_Mutation_p.T1402I|JMJD1C_uc001jmm.2_Missense_Mutation_p.T1333I|JMJD1C_uc010qiq.1_Missense_Mutation_p.T1439I|JMJD1C_uc009xpi.2_Missense_Mutation_p.T1439I|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.T658I	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1621					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGATTCATAAGTTCTTTTGGC	0.348													24	71					0	0	0	0	A	64966567	A	A	64966567	3	1	226	1	0	0	0	0	1	0	0	0	7989	1029	36	4	2828	4	JMJD1C	10	64966567	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	16578061	64966567	70568180	71	41416											
HKDC1	80201	broad.mit.edu	37	chr10	70992576	70992576	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaagttccgagtgctgaagGtgcaagtcgctgaagagggg	10	7	16	8	2	0	3	0	2	0	1	2	4	1	3	2	3	2	4	2	3	4	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr10:70992576G>T	uc001jpf.3	+	3	416	c.283G>T	c.(283-285)GTG>TTG	p.V95L	HKDC1_uc010qje.1_5'Flank	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	95					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						AGTGCTGAAGGTGCAAGTCGC	0.458													37	100					1.42033e-22	8.86524e-22	1	0	T	70992576	T	T	70992576	3	4	226	1	0	0	0	0	1	0	0	0	7232	1261	44	4	293	4	HKDC1	10	70992576	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	6026009	70992576	64542171	72	41417											
STAMBPL1	57559	broad.mit.edu	37	chr10	90665316	90665316	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaagacatcactccacgAcgttactttaggtctggagt	11	11	10	9	2	2	2	1	1	1	1	3	4	3	3	1	2	1	1	1	2	3	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr10:90665316A>G	uc001kfk.2	+	3	570	c.147A>G	c.(145-147)CGA>CGG	p.R49R	STAMBPL1_uc010qmx.1_Silent_p.R49R|STAMBPL1_uc009xto.2_RNA|STAMBPL1_uc001kfl.2_Silent_p.R49R|STAMBPL1_uc001kfm.2_5'Flank	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	49							metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TCACTCCACGACGTTACTTTA	0.423													27	58					0	0	0	0	G	90665316	G	G	90665316	2	3	226	1	0	0	0	0	0	0	0	1	15317	262	10	5		5	STAMBPL1	10	90665316	Silent	SNP	A	TCGA-CV-7104-01A-11D-2012-08	19672740	90665316	44869431	73	41418											
TNKS2	80351	broad.mit.edu	37	chr10	93619309	93619309	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggagctggcatttattttgCtgaaaactcttccaaaagca	12	13	8	8	0	1	1	0	1	1	0	2	2	2	2	1	2	4	4	1	2	5	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr10:93619309C>T	uc001khp.2	+	25	3482	c.3185C>T	c.(3184-3186)GCT>GTT	p.A1062V		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1062	PARP catalytic.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				ATTTATTTTGCTGAAAACTCT	0.403													25	62					0	0	0	0	T	93619309	T	T	93619309	3	4	226	1	0	0	0	0	1	0	0	0	16387	797	28	4	3283	4	TNKS2	10	93619309	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	2953993	93619309	41915438	74	41419											
MMS19	64210	broad.mit.edu	37	chr10	99228076	99228076	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgacagagtcacaggccCgggcagatgcacctgcagct	9	6	14	12	1	1	3	1	1	0	2	1	3	1	3	2	3	3	4	2	3	0	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr10:99228076C>T	uc001kns.3	-	13	1376	c.1151G>A	c.(1150-1152)CGG>CAG	p.R384Q	MMS19_uc009xvs.2_5'Flank|MMS19_uc009xvt.2_Intron|MMS19_uc001knr.2_Missense_Mutation_p.R226Q|MMS19_uc010qox.1_Missense_Mutation_p.R362Q|MMS19_uc001knt.2_Missense_Mutation_p.R384Q|MMS19_uc001knu.1_RNA	NM_022362	NP_071757	Q96T76	MMS19_HUMAN	MMS19 nucleotide excision repair homolog	384					chromosome segregation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent|two-component signal transduction system (phosphorelay)	cytoplasm|holo TFIIH complex|MMXD complex	estrogen receptor binding|protein binding, bridging|receptor signaling complex scaffold activity|transcription coactivator activity				0		Colorectal(252;0.0846)		Epithelial(162;3.33e-10)|all cancers(201;2.74e-08)		GTCACAGGCCCGGGCAGATGC	0.552								Direct_reversal_of_damage|NER					22	74					0	0	0	0	T	99228076	T	T	99228076	3	4	226	1	0	0	0	0	1	0	0	0	9725	652	23	1	2017	1	MMS19	10	99228076	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	5608767	99228076	36306671	75	41420											
ADAM12	8038	broad.mit.edu	37	chr10	127724751	127724751	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggcttggctggcaggggTctggcagggacgctaggtgc	5	7	20	9	1	1	0	0	0	1	0	1	1	1	1	0	8	1	6	0	8	1	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr10:127724751T>G	uc001ljk.2	-	21	2915	c.2502A>C	c.(2500-2502)AGA>AGC	p.R834S	ADAM12_uc010qul.1_Missense_Mutation_p.R785S	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	834	SH3-binding; class II (By similarity).|SH3-binding; class I (By similarity).|Cytoplasmic (Potential).				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CTGGCAGGGGTCTGGCAGGGA	0.502													10	48					0	0	0	0	G	127724751	G	G	127724751	3	3	226	1	0	0	0	0	1	0	0	0	236	1664	58	5	239	5	ADAM12	10	127724751	Missense_Mutation	SNP	T	TCGA-CV-7104-01A-11D-2012-08	28496675	127724751	7809996	76	41421											
TNNT3	7140	broad.mit.edu	37	chr11	1956071	1956071	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccccagggacaaggccaaGgagctctgggagaccctgca	10	4	14	13	0	1	1	0	0	1	1	1	4	1	3	4	4	3	2	4	4	2	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr11:1956071G>A	uc001luu.3	+	14	815	c.603G>A	c.(601-603)AAG>AAA	p.K201K	TNNT3_uc001lun.2_Silent_p.K97K|TNNT3_uc001luw.3_Silent_p.K193K|TNNT3_uc001luo.3_Silent_p.K193K|TNNT3_uc001lup.3_Silent_p.K199K|TNNT3_uc001luq.3_Silent_p.K193K|TNNT3_uc001lur.2_Silent_p.K193K|TNNT3_uc010qxf.1_Silent_p.K199K|TNNT3_uc010qxg.1_Silent_p.K133K	NM_006757	NP_006748	P45378	TNNT3_HUMAN	troponin T3, skeletal, fast isoform 1	212					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		ACAAGGCCAAGGAGCTCTGGG	0.612													46	149					0	0	0	0	A	1956071	A	A	1956071	2	1	226	1	0	0	0	0	0	0	0	1	16398	991	35	4		4	TNNT3	11	1956071	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08		1956071	133050445	77	41422											
ART1	417	broad.mit.edu	37	chr11	3681420	3681420	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcttcggcatctggacctGccttggggcccctatcaagg	5	11	11	14	1	3	0	1	0	2	0	4	1	3	1	4	5	1	1	4	5	2	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr11:3681420G>T	uc001lye.1	+	3	772	c.671G>T	c.(670-672)TGC>TTC	p.C224F	ART1_uc009yeb.1_Missense_Mutation_p.C224F	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	224					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	ATCTGGACCTGCCTTGGGGCC	0.602													20	55					8.28177e-16	5.00246e-15	1	0	T	3681420	T	T	3681420	3	4	226	1	0	0	0	0	1	0	0	0	999	1319	46	4	677	4	ART1	11	3681420	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	1725349	3681420	131325096	78	41423											
DCDC1	341019	broad.mit.edu	37	chr11	31312208	31312208	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattacctttttcattgtttCttttcccactgtaatctcat	8	21	2	10	0	3	0	2	0	2	0	5	0	4	0	2	0	1	2	2	0	3	8			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr11:31312208C>A	uc001msv.2	-	7	1148	c.946G>T	c.(946-948)GAA>TAA	p.E316*	DCDC1_uc001msu.1_Intron	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	316					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					TTCATTGTTTCTTTTCCCACT	0.323													12	38					5.16669e-11	2.97681e-10	1	0	A	31312208	A	A	31312208	4	1	226	1	0	0	0	0	0	1	0	0	4301	922	32	2	130	2	DCDC1	11	31312208	Nonsense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	27630788	31312208	103694308	79	41424											
PHF21A	51317	broad.mit.edu	37	chr11	45967551	45967551	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcattgtattttggaggaCgacctatataccaagagaag	13	11	10	7	1	0	1	0	0	0	1	0	5	0	3	2	2	2	2	2	2	6	7			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr11:45967551C>T	uc001ncc.3	-	14	1913	c.1289G>A	c.(1288-1290)CGT>CAT	p.R430H	PHF21A_uc001ncb.3_Intron|PHF21A_uc009ykx.2_Intron|PHF21A_uc001nce.2_Missense_Mutation_p.R431H|PHF21A_uc001nca.1_Missense_Mutation_p.R166H	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	430	A.T hook.				blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						TTTTGGAGGACGACCTATATA	0.488													20	72					0	0	0	0	T	45967551	T	T	45967551	3	4	226	1	0	0	0	0	1	0	0	0	11888	536	19	1	773	1	PHF21A	11	45967551	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	14655343	45967551	89038965	80	41425											
OR5D13	390142	broad.mit.edu	37	chr11	55540981	55540981	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgggtttttcagaataccCagaaatccaggttccactct	10	13	7	11	0	2	2	1	0	1	2	4	2	4	2	3	2	1	2	3	2	3	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr11:55540981C>T	uc010ril.1	+	1	68	c.68C>T	c.(67-69)CCA>CTA	p.P23L		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	23	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TCAGAATACCCAGAAATCCAG	0.373													9	120					0	0	0	0	T	55540981	T	T	55540981	3	4	226	1	0	0	0	0	1	0	0	0	11208	594	21	4	70	4	OR5D13	11	55540981	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	9573430	55540981	79465535	81	41426											
PCNXL3	399909	broad.mit.edu	37	chr11	65396095	65396095	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgctgtacaagctgcgtttCgtgctgacctacatcgcgcc	6	12	10	13	4	0	1	0	1	0	0	2	1	0	1	2	0	6	5	2	0	3	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr11:65396095C>T	uc001oey.2	+	23	3732	c.3732C>T	c.(3730-3732)TTC>TTT	p.F1244F	PCNXL3_uc001oez.2_Silent_p.F131F	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1244	Helical; (Potential).					integral to membrane					0						AGCTGCGTTTCGTGCTGACCT	0.602													20	52					0	0	0	0	T	65396095	T	T	65396095	2	4	226	1	0	0	0	0	0	0	0	1	11647	883	31	1		1	PCNXL3	11	65396095	Silent	SNP	C	TCGA-CV-7104-01A-11D-2012-08	9855114	65396095	69610421	82	41427											
WNK1	65125	broad.mit.edu	37	chr12	993920	993920	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagacgtgcccaaatgacagAaggacccaacacagcacctc	15	4	8	14	1	0	3	0	1	0	2	1	4	0	4	3	1	3	1	3	1	4	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr12:993920A>G	uc001qio.3	+	19	4457	c.3950A>G	c.(3949-3951)GAA>GGA	p.E1317G	WNK1_uc001qip.3_Missense_Mutation_p.E1070G|WNK1_uc001qir.3_Missense_Mutation_p.E490G	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1317					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CAAATGACAGAAGGACCCAAC	0.478													37	71					0	0	0	0	G	993920	G	G	993920	3	3	226	1	0	0	0	0	1	0	0	0	17445	246	9	5	5526	5	WNK1	12	993920	Missense_Mutation	SNP	A	TCGA-CV-7104-01A-11D-2012-08		993920	132857975	83	41428											
TAS2R7	50837	broad.mit.edu	37	chr12	10954441	10954443	+	In_Frame_Del	DEL	GAG	-	-																															gacaaatagtaggcaataaaGaggagaaggaaggaaatgac																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr12:10954441_10954443delGAG	uc001qyv.2	-	1	784_786	c.727_729delCTC	c.(727-729)CTCdel	p.L243del		NM_023919	NP_076408	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	243	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						AGGCAATAAAGAGGAGAAGGAAG	0.483													---	---	---								-	10954443	-	-	10954441	7	5	226	1	0	1	0	1	0	0	0	0	15652	929	33	0	231	0	TAS2R7	12	10954441	In_Frame_Del	DEL	GAG	TCGA-CV-7104-01A-11D-2012-08	9960521	10954441	122897454	84	41429											
ADAMTS20	80070	broad.mit.edu	37	chr12	43826562	43826562	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaatggatgtccaaggttcTatatccttgaccacattggg	10	12	10	9	0	1	1	0	1	1	0	3	2	3	2	3	3	0	2	3	3	4	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr12:43826562T>C	uc010skx.1	-	20	2773	c.2773A>G	c.(2773-2775)AGA>GGA	p.R925G	ADAMTS20_uc001rno.1_Missense_Mutation_p.R79G|ADAMTS20_uc001rnp.1_Missense_Mutation_p.R79G	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	925	TSP type-1 3.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCCAAGGTTCTATATCCTTGA	0.383													3	176					0	0	0	0	C	43826562	C	C	43826562	3	2	226	1	0	0	0	0	1	0	0	0	266	1530	53	5	3038	5	ADAMTS20	12	43826562	Missense_Mutation	SNP	T	TCGA-CV-7104-01A-11D-2012-08	32872121	43826562	90025333	85	41430											
SLC26A10	65012	broad.mit.edu	37	chr12	58014188	58014189	+	Missense_Mutation	DNP	CC	AA	AA																															actctacacttctttcttccCcgtcctcatctacagcttgc																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr12:58014188_58014189CC>AA	uc001spe.2	+	1	496_497	c.185_186CC>AA	c.(184-186)CCC>CAA	p.P62Q	uc001spc.2_5'Flank|SLC26A10_uc001spf.2_RNA	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	62	Helical; (Potential).					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					TCTTTCTTCCCCGTCCTCATCT	0.54													10	624					0	0	0	0	AA	58014189	AA	AA	58014188	3	1	226	1	0	0	0	0	1	0	0	0	14579	623	22	4	187	4	SLC26A10	12	58014188	Missense_Mutation	DNP	CC	TCGA-CV-7104-01A-11D-2012-08	14187626	58014188	75837707	86	41431											
B4GALNT1	2583	broad.mit.edu	37	chr12	58021971	58021971	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcgtccgcgccgtgaagacGaagtcgtcgtccacccacag	8	5	12	16	8	0	2	0	1	0	1	4	3	2	2	4	0	0	0	4	0	2	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr12:58021971G>A	uc001spg.1	-	9	1509	c.1077C>T	c.(1075-1077)TTC>TTT	p.F359F	B4GALNT1_uc010sru.1_Silent_p.F304F	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	359	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CCGTGAAGACGAAGTCGTCGT	0.652													17	75					0	0	0	0	A	58021971	A	A	58021971	2	1	226	1	0	0	0	0	0	0	0	1	1268	1049	37	1		1	B4GALNT1	12	58021971	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	7783	58021971	75829924	87	41432											
WSCD2	9671	broad.mit.edu	37	chr12	108618515	108618515	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttctctctggctcttcaGatggaagtgcagtgttccgg	5	14	11	11	1	5	1	1	0	4	1	7	2	6	2	1	3	1	3	1	3	1	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr12:108618515G>T	uc001tms.2	+	5	1427	c.683_splice	c.e5-1	p.Y228_splice	WSCD2_uc001tmt.2_Splice_Site_p.Y228_splice|WSCD2_uc001tmu.2_5'Flank	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2							integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						TGGCTCTTCAGATGGAAGTGC	0.448													22	86					9.95505e-16	5.96507e-15	1	0	T	108618515	T	T	108618515	5	4	226	1	0	0	0	0	0	0	1	0	17475	956	33	2	696	2	WSCD2	12	108618515	Splice_Site	SNP	G	TCGA-CV-7104-01A-11D-2012-08	50596544	108618515	25233380	88	41433											
FAM101A	144347	broad.mit.edu	37	chr12	124798965	124798965	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggagcactttccggaccaCcctgcactgcagcctgggcc	7	6	11	17	1	0	0	0	0	0	0	1	2	1	2	5	3	4	3	5	3	0	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr12:124798965C>A	uc001ugd.1	+	3	545	c.302C>A	c.(301-303)ACC>AAC	p.T101N	FAM101A_uc001uge.1_Missense_Mutation_p.T101N	NM_181709	NP_859060	Q6ZTI6	F101A_HUMAN	hypothetical protein LOC144347	182											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		TTCCGGACCACCCTGCACTGC	0.706													26	59					7.33532e-06	3.98127e-05	1	0	A	124798965	A	A	124798965	3	1	226	1	0	0	0	0	1	0	0	0	5408	507	18	4	308	4	FAM101A	12	124798965	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	16180450	124798965	9052930	89	41434											
POTEG	404785	broad.mit.edu	37	chr14	19553628	19553628	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgccgccactgcttcccctGgtgcagggggagcagcaaga	7	6	15	13	1	0	1	0	0	0	1	1	2	1	2	4	3	5	4	4	3	1	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr14:19553628G>T	uc001vuz.1	+	1	264	c.212G>T	c.(211-213)TGG>TTG	p.W71L	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	71										ovary(1)	1						TGCTTCCCCTGGTGCAGGGGG	0.587													80	698					5.80444e-35	3.78045e-34	1	0	T	19553628	T	T	19553628	3	4	226	1	0	0	0	0	1	0	0	0	12321	1357	47	4	214	4	POTEG	14	19553628	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08		19553628	87795912	90	41435											
HEATR5A	25938	broad.mit.edu	37	chr14	31814337	31814337	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taataagggcattcaaacagCgaccaaggctttggtgaact	14	9	10	8	1	1	1	1	1	0	0	1	2	1	1	1	3	3	2	1	3	5	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr14:31814337C>T	uc001wrf.3	-	14	2212	c.2135G>A	c.(2134-2136)CGC>CAC	p.R712H	HEATR5A_uc010ami.2_Missense_Mutation_p.R610H|HEATR5A_uc001wrg.1_Missense_Mutation_p.R594H|HEATR5A_uc010tpk.1_Missense_Mutation_p.R1005H	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	999							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		ATTCAAACAGCGACCAAGGCT	0.388													35	111					0	0	0	0	T	31814337	T	T	31814337	3	4	226	1	0	0	0	0	1	0	0	0	7070	768	27	1	3194	1	HEATR5A	14	31814337	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	12260709	31814337	75535203	91	41436											
TXNDC16	57544	broad.mit.edu	37	chr14	53010231	53010231	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtaaaaaatgcacattatGacaaaagagatcccaactct	19	9	5	8	0	1	2	0	1	1	1	2	3	2	2	1	0	2	2	1	0	7	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr14:53010231G>C	uc001wzs.2	-	3	494	c.45C>G	c.(43-45)GTC>GTG	p.V15V	TXNDC16_uc010tqu.1_Silent_p.V15V|TXNDC16_uc010aoe.2_RNA	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1	15					cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					TGCACATTATGACAAAAGAGA	0.318													16	50					0	0	0	0	C	53010231	C	C	53010231	2	2	226	1	0	0	0	0	0	0	0	1	16863	1277	45	2		2	TXNDC16	14	53010231	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	21195894	53010231	54339309	92	41437											
OR4N4	283694	broad.mit.edu	37	chr15	22382574	22382574	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtgctgatcttaattttCtaccttatcatcctccctgg	6	19	5	11	0	3	1	1	1	2	0	5	1	5	1	3	1	2	1	3	1	3	6			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr15:22382574C>A	uc001yuc.1	+	7	1083	c.102C>A	c.(100-102)TTC>TTA	p.F34L	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.F34L	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	34	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTTAATTTTCTACCTTATCA	0.423													67	98					2.36135e-34	1.5247e-33	1	0	A	22382574	A	A	22382574	3	1	226	1	0	0	0	0	1	0	0	0	11132	912	32	2	104	2	OR4N4	15	22382574	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08		22382574	80148818	93	41438											
TRIM69	140691	broad.mit.edu	37	chr15	45047401	45047401	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaagttggtagagaagattAagaagttacccttactcaag	16	10	9	6	0	1	3	1	0	0	3	1	4	1	3	1	1	2	3	1	1	8	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr15:45047401A>T	uc001zuf.2	+	3	1205	c.310A>T	c.(310-312)AAG>TAG	p.K104*	TRIM69_uc001zui.1_Intron|TRIM69_uc010bdy.1_Intron|TRIM69_uc001zug.1_Nonsense_Mutation_p.K104*|TRIM69_uc001zuh.1_Intron	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	104	Necessary for nuclear localization (By similarity).				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		AGAGAAGATTAAGAAGTTACC	0.438													23	33					0	0	0	0	T	45047401	T	T	45047401	4	4	226	1	0	0	0	0	0	1	0	0	16609	363	13	5	316	5	TRIM69	15	45047401	Nonsense_Mutation	SNP	A	TCGA-CV-7104-01A-11D-2012-08	22664827	45047401	57483991	94	41439											
FAM81A	145773	broad.mit.edu	37	chr15	59806519	59806519	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttgaggaactcagtaacCagatattatctgcacggagt	13	10	10	8	1	2	2	1	1	1	1	2	4	2	4	1	2	3	3	1	2	4	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr15:59806519C>A	uc002agc.2	+	7	869	c.682C>A	c.(682-684)CAG>AAG	p.Q228K		NM_152450	NP_689663	Q8TBF8	FA81A_HUMAN	hypothetical protein LOC145773	228										ovary(1)	1						ACTCAGTAACCAGATATTATC	0.279													16	28					0.000308642	0.00163952	1	0	A	59806519	A	A	59806519	3	1	226	1	0	0	0	0	1	0	0	0	5660	595	21	4	704	4	FAM81A	15	59806519	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	14759118	59806519	42724873	95	41440											
POLG	5428	broad.mit.edu	37	chr15	89864134	89864134	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagatgcggccgtagttgaaGattttggcatgctcacggct	8	12	13	8	3	1	3	1	1	0	2	1	3	1	3	1	3	2	5	1	3	3	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr15:89864134G>A	uc002bns.3	-	18	3126	c.2844C>T	c.(2842-2844)ATC>ATT	p.I948I	POLG_uc002bnr.3_Silent_p.I948I	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	948					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			CGTAGTTGAAGATTTTGGCAT	0.557								DNA_polymerases_(catalytic_subunits)					14	32					0	0	0	0	A	89864134	A	A	89864134	2	1	226	1	0	0	0	0	0	0	0	1	12255	932	33	2		2	POLG	15	89864134	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	30057615	89864134	12667258	96	41441											
OR2C1	4993	broad.mit.edu	37	chr16	3406177	3406177	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcgctactagttcagtcccCcaaatgctgatcaatttatg	10	14	6	11	1	2	1	2	1	0	0	4	1	3	1	2	0	2	3	2	0	5	6			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr16:3406177C>G	uc002cuw.1	+	1	289	c.237C>G	c.(235-237)CCC>CCG	p.P79P		NM_012368	NP_036500	O95371	OR2C1_HUMAN	olfactory receptor, family 2, subfamily C,	79	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GTTCAGTCCCCCAAATGCTGA	0.547													56	44					0	0	0	0	G	3406177	G	G	3406177	2	3	226	1	0	0	0	0	0	0	0	1	11046	610	22	4		4	OR2C1	16	3406177	Silent	SNP	C	TCGA-CV-7104-01A-11D-2012-08		3406177	86948576	97	41442											
PAPD5	64282	broad.mit.edu	37	chr16	50259097	50259097	+	Frame_Shift_Del	DEL	T	-	-																															aatgaagcccttggaaaatgTagaagtaaaacctcggaatc																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr16:50259097delT	uc010vgo.1	+	11	1691	c.1656delT	c.(1654-1656)TGTfs	p.C552fs	PAPD5_uc010cbi.2_RNA|PAPD5_uc002efz.2_Intron|PAPD5_uc002ega.2_Frame_Shift_Del_p.C343fs	NM_001040284	NP_001035374	Q8NDF8	PAPD5_HUMAN	PAP associated domain containing 5 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell division|DNA replication|histone mRNA catabolic process|mitosis	cytoplasm|nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding				0		all_cancers(37;0.0452)		BRCA - Breast invasive adenocarcinoma(181;0.0843)|GBM - Glioblastoma multiforme(240;0.231)		TTGGAAAATGTAGAAGTAAAA	0.393													---	---	---								-	50259097	-	-	50259097	7	5	226	1	0	1	0	1	0	0	0	0	11479	1644	57	0	1698	0	PAPD5	16	50259097	Frame_Shift_Del	DEL	T	TCGA-CV-7104-01A-11D-2012-08	46852920	50259097	40095656	98	41443											
SETD6	79918	broad.mit.edu	37	chr16	58552079	58552079	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttgaaccatatcctgacaAcacagatgacacagctgaca	15	8	7	11	0	0	5	0	4	0	1	1	5	1	5	2	0	3	2	2	0	3	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr16:58552079A>G	uc002ens.2	+	6	976	c.917A>G	c.(916-918)AAC>AGC	p.N306S	SETD6_uc002enr.2_Missense_Mutation_p.N282S|SETD6_uc010cdm.2_RNA	NM_001160305	NP_001153777	Q8TBK2	SETD6_HUMAN	SET domain containing 6 isoform a	306					negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			ovary(1)	1						TATCCTGACAACACAGATGAC	0.428													17	49					0	0	0	0	G	58552079	G	G	58552079	3	3	226	1	0	0	0	0	1	0	0	0	14200	43	2	5	939	5	SETD6	16	58552079	Missense_Mutation	SNP	A	TCGA-CV-7104-01A-11D-2012-08	8292982	58552079	31802674	99	41444											
HP	3240	broad.mit.edu	37	chr16	72094489	72094489	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcctgtggctgaccaagaCcaatgcataaggcattatga	12	9	10	10	0	0	3	0	2	0	1	0	3	0	3	3	2	2	3	3	2	4	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr16:72094489C>T	uc002fbr.3	+	7	965	c.921C>T	c.(919-921)GAC>GAT	p.D307D	TXNL4B_uc010cgl.2_Intron|HP_uc010cgm.2_Silent_p.D248D|HP_uc002fbt.3_Silent_p.D248D|HP_uc002fbu.1_Silent_p.D45D|HP_uc002fbv.3_Silent_p.D218D|HP_uc002fbw.3_Silent_p.D129D|HP_uc002fbx.3_Silent_p.D129D|HPR_uc002fby.2_5'Flank	NM_005143	NP_005134	P00738	HPT_HUMAN	haptoglobin isoform 1 preproprotein	307	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity				0		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		CTGACCAAGACCAATGCATAA	0.493													15	42					0	0	0	0	T	72094489	T	T	72094489	2	4	226	1	0	0	0	0	0	0	0	1	7366	506	18	4		4	HP	16	72094489	Silent	SNP	C	TCGA-CV-7104-01A-11D-2012-08	13542410	72094489	18260264	100	41445											
ZFHX3	463	broad.mit.edu	37	chr16	72821365	72821365	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggaagcggaggagggggCggcggccgacgggggagggg	6	0	29	6	5	0	0	0	0	0	0	0	5	0	4	1	12	1	0	1	12	1	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr16:72821365C>T	uc002fck.2	-	10	11483	c.10810G>A	c.(10810-10812)GCC>ACC	p.A3604T	uc002fcj.1_Intron|ZFHX3_uc002fcl.2_Missense_Mutation_p.A2690T	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3604					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GAGGAGGGGGCGGCGGCCGAC	0.652													9	35					0	0	0	0	T	72821365	T	T	72821365	3	4	226	1	0	0	0	0	1	0	0	0	17701	768	27	1	305	1	ZFHX3	16	72821365	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	726876	72821365	17533388	101	41446											
MBTPS1	8720	broad.mit.edu	37	chr16	84088086	84088086	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtctttggcgggtgaacctGctgcatgagctgcgggcgct	4	10	17	10	3	1	2	0	2	1	0	1	2	1	2	1	4	5	4	1	4	1	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr16:84088086G>T	uc002fhi.2	-	23	3629	c.3127C>A	c.(3127-3129)CAG>AAG	p.Q1043K	MBTPS1_uc002fhh.2_Missense_Mutation_p.Q547K	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	1043	Arg/Lys/Pro-rich (basic).|Cytoplasmic (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						GGGTGAACCTGCTGCATGAGC	0.642													7	26					0.000274275	0.00146737	1	0	T	84088086	T	T	84088086	3	4	226	1	0	0	0	0	1	0	0	0	9414	1328	46	4	35	4	MBTPS1	16	84088086	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	11266721	84088086	6266667	102	41447											
SMG6	23293	broad.mit.edu	37	chr17	2200598	2200598	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtagtcttccagtttgaacTtgtaagtaacctgcagcttc	9	15	8	9	0	1	1	0	1	1	0	3	1	2	1	2	0	4	6	2	0	4	7	rs143802482		TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr17:2200598T>A	uc002fub.1	-	4	2145	c.2090A>T	c.(2089-2091)AAG>ATG	p.K697M		NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	697					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						CAGTTTGAACTTGTAAGTAAC	0.348													34	93					0	0	0	0	A	2200598	A	A	2200598	3	1	226	1	0	0	0	0	1	0	0	0	14861	1609	56	5	2233	5	SMG6	17	2200598	Missense_Mutation	SNP	T	TCGA-CV-7104-01A-11D-2012-08		2200598	78994612	103	41448											
GPR172B	55065	broad.mit.edu	37	chr17	4937188	4937188	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaccagaagggcagtcagtGcccagaagaaggtgctggca	12	5	15	9	0	1	4	1	1	0	3	1	4	1	4	2	3	2	3	2	3	3	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr17:4937188G>T	uc002gap.3	-	3	1309	c.596C>A	c.(595-597)GCA>GAA	p.A199E	GPR172B_uc002gao.3_Missense_Mutation_p.A199E|GPR172B_uc010ckw.2_Missense_Mutation_p.A77E|GPR172B_uc010ckx.2_Missense_Mutation_p.A199E	NM_001104577	NP_001098047	Q9NWF4	RFT_HUMAN	G protein-coupled receptor 172B precursor	199	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0						GGCAGTCAGTGCCCAGAAGAA	0.637													31	81					9.04072e-19	5.59628e-18	1	0	T	4937188	T	T	4937188	3	4	226	1	0	0	0	0	1	0	0	0	6708	1319	46	4	762	4	GPR172B	17	4937188	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	2736590	4937188	76258022	104	41449											
TP53	7157	broad.mit.edu	37	chr17	7577609	7577609	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtacagtcagagccaacCtaggagataacacaggccca	14	5	11	11	0	1	2	1	0	0	2	1	3	1	2	3	3	4	1	3	3	4	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr17:7577609C>T	uc002gim.2	-	7	867	c.673_splice	c.e7-1	p.V225_splice	TP53_uc002gig.1_Splice_Site_p.V225_splice|TP53_uc002gih.2_Splice_Site_p.V225_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.V93_splice|TP53_uc010cng.1_Splice_Site_p.V93_splice|TP53_uc002gii.1_Splice_Site_p.V93_splice|TP53_uc010cnh.1_Splice_Site_p.V225_splice|TP53_uc010cni.1_Splice_Site_p.V225_splice|TP53_uc002gij.2_Splice_Site_p.V225_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(12)|p.0?(7)|p.V225fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGAGCCAACCTAGGAGATAA	0.488		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	49					0	0	0	0	T	7577609	T	T	7577609	5	4	226	1	0	0	0	0	0	0	1	0	16448	695	24	4	618	4	TP53	17	7577609	Splice_Site	SNP	C	TCGA-CV-7104-01A-11D-2012-08	2640421	7577609	73617601	105	41450											
TP53	7157	broad.mit.edu	37	chr17	7579575	7579575	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcaaatcatccattgcttGggacggcaagggggactgta	11	9	12	9	1	2	0	2	0	0	0	3	2	3	2	1	4	1	3	1	4	3	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr17:7579575G>A	uc002gim.2	-	4	306	c.112C>T	c.(112-114)CAA>TAA	p.Q38*	TP53_uc002gig.1_Nonsense_Mutation_p.Q38*|TP53_uc002gih.2_Nonsense_Mutation_p.Q38*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.Q38*|TP53_uc010cni.1_Nonsense_Mutation_p.Q38*|TP53_uc002gij.2_Nonsense_Mutation_p.Q38*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_5'UTR|TP53_uc010cnk.1_Nonsense_Mutation_p.Q53*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	38	Transcription activation (acidic).|Interaction with HRMT1L2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.Q38*(2)|p.?(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.S37fs*79(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCATTGCTTGGGACGGCAAG	0.418		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			51	180					0	0	0	0	A	7579575	A	A	7579575	4	1	226	1	0	0	0	0	0	1	0	0	16448	1357	47	4	1190	4	TP53	17	7579575	Nonsense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	1966	7579575	73615635	106	41451											
MYH4	4622	broad.mit.edu	37	chr17	10362627	10362627	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagtcaatgaactcccactCgatgccttccttcttgtact	9	13	6	13	1	2	1	1	1	1	0	5	3	4	1	3	0	3	1	3	0	4	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr17:10362627C>T	uc002gmn.2	-	15	1639	c.1528G>A	c.(1528-1530)GAG>AAG	p.E510K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	510	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AACTCCCACTCGATGCCTTCC	0.473													26	103					0	0	0	0	T	10362627	T	T	10362627	3	4	226	1	0	0	0	0	1	0	0	0	10090	893	31	1	4395	1	MYH4	17	10362627	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	2783052	10362627	70832583	107	41452											
GGNBP2	79893	broad.mit.edu	37	chr17	34945780	34945780	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaatttaataaatactgccGgttaaatgatcacaagaggc	17	10	8	6	1	1	2	1	1	0	1	1	3	1	2	1	2	2	1	1	2	8	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr17:34945780G>A	uc002hnb.2	+	14	2282	c.2033G>A	c.(2032-2034)CGG>CAG	p.R678Q	DHRS11_uc002hnd.2_5'Flank	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	678					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		AAATACTGCCGGTTAAATGAT	0.373													55	129					0	0	0	0	A	34945780	A	A	34945780	3	1	226	1	0	0	0	0	1	0	0	0	6396	1116	39	1	2083	1	GGNBP2	17	34945780	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	24583153	34945780	46249430	108	41453											
TADA2A	6871	broad.mit.edu	37	chr17	35800747	35800747	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagcaaaaactgctgacacAgccattccatttcactgtaa	15	9	6	11	0	1	1	1	1	0	0	2	2	2	1	2	0	4	3	2	0	4	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr17:35800747A>G	uc002hnt.2	+	6	583	c.426A>G	c.(424-426)ACA>ACG	p.T142T	TADA2A_uc002hnu.1_Silent_p.T142T|TADA2A_uc002hnv.2_Silent_p.T142T|TADA2A_uc010wdd.1_Silent_p.T142T|TADA2A_uc002hnw.2_Silent_p.T41T|TADA2A_uc010cvb.2_5'UTR	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	142					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						CTGCTGACACAGCCATTCCAT	0.423													5	37					0	0	0	0	G	35800747	G	G	35800747	2	3	226	1	0	0	0	0	0	0	0	1	15576	175	7	5		5	TADA2A	17	35800747	Silent	SNP	A	TCGA-CV-7104-01A-11D-2012-08	854967	35800747	45394463	109	41454											
STARD3	10948	broad.mit.edu	37	chr17	37817129	37817129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaggggctgcgggcggcGtggtctccccaaggtgagtc	4	7	18	12	3	1	1	0	1	1	0	3	1	1	1	2	6	2	2	2	6	1	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr17:37817129G>A	uc002hsd.2	+	12	1145	c.1021G>A	c.(1021-1023)GTG>ATG	p.V341M	STARD3_uc010weh.1_RNA|STARD3_uc002hse.2_Missense_Mutation_p.V323M|STARD3_uc010wei.1_Missense_Mutation_p.V341M|STARD3_uc002hsf.2_Missense_Mutation_p.V207M|STARD3_uc002hsg.2_Missense_Mutation_p.V174M	NM_006804	NP_006795	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain	341	START.|Cytoplasmic (Potential).				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TGCGGGCGGCGTGGTCTCCCC	0.607													40	95					0	0	0	0	A	37817129	A	A	37817129	3	1	226	1	0	0	0	0	1	0	0	0	15323	1145	40	1	1076	1	STARD3	17	37817129	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	2016382	37817129	43378081	110	41455											
BPTF	2186	broad.mit.edu	37	chr17	65914934	65914934	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcggccaaggctcctccagGaggagggactacacggacag	10	3	16	12	2	0	0	0	0	0	0	2	4	2	4	3	7	1	1	3	7	2	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr17:65914934G>T	uc002jgf.2	+	12	5469	c.5408G>T	c.(5407-5409)GGA>GTA	p.G1803V	BPTF_uc002jge.2_Missense_Mutation_p.G1929V	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1929					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GCTCCTCCAGGAGGAGGGACT	0.398													33	73					8.16721e-17	5.01413e-16	1	0	T	65914934	T	T	65914934	3	4	226	1	0	0	0	0	1	0	0	0	1500	1174	41	2	5840	2	BPTF	17	65914934	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	28097805	65914934	15280276	111	41456											
THOP1	7064	broad.mit.edu	37	chr19	2810358	2810358	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggactttgtggaggcgccGtcgcagatgctggagaactg	7	8	17	9	4	0	2	0	0	0	2	1	5	0	4	1	4	2	2	1	4	1	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr19:2810358G>A	uc002lwj.2	+	10	1667	c.1512G>A	c.(1510-1512)CCG>CCA	p.P504P	THOP1_uc010xgz.1_Silent_p.P383P|THOP1_uc002lwk.2_Silent_p.P15P	NM_003249	NP_003240	P52888	THOP1_HUMAN	thimet oligopeptidase 1	504					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGAGGCGCCGTCGCAGATGC	0.682													17	25					0	0	0	0	A	2810358	A	A	2810358	2	1	226	1	0	0	0	0	0	0	0	1	15937	1132	40	1		1	THOP1	19	2810358	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08		2810358	56318625	112	41457											
ARRDC5	645432	broad.mit.edu	37	chr19	4903031	4903032	+	5'Flank	INS	-	TCACTGGTTCTTTT	TCACTGGTTCTTTT																															gattgggaaacctgtagtccINStcactggttctttttttttt																								rs144459964	by1000genomes	TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr19:4903031_4903032insTCACTGGTTCTTTT	uc002mbm.2	-							NM_001080523	NP_001073992	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5						signal transduction						0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		ACCTGTAGTCCTCACTGGttct	0.302													---	---	---								TCACTGGTTCTTTT	4903032	TCACTGGTTCTTTT	TCACTGGTTCTTTT	4903031	6	5	226	0	1	1	1	0	0	0	0	0	988	696	24	0		0	ARRDC5	19	4903031	5'Flank	INS	-	TCGA-CV-7104-01A-11D-2012-08	2092673	4903031	54225952	113	41458											
MUC16	94025	broad.mit.edu	37	chr19	9048464	9048464	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagaatcagagttggaataCttgtactgtttactccacta	14	13	7	7	0	1	2	1	0	0	2	2	3	2	3	1	1	3	3	1	1	7	7			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr19:9048464C>A	uc002mkp.2	-	5	33371	c.33167G>T	c.(33166-33168)AGT>ATT	p.S11056I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11058	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTTGGAATACTTGTACTGTT	0.498													30	118					7.26314e-15	4.31753e-14	1	0	A	9048464	A	A	9048464	3	1	226	1	0	0	0	0	1	0	0	0	10026	565	20	4	10676	4	MUC16	19	9048464	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	4145433	9048464	50080519	114	41459											
ZNF699	374879	broad.mit.edu	37	chr19	9415943	9415946	+	5'Flank	DEL	ACAC	-	-																															caactcccctcaaaacacatAcacacacacacacacacaca																										TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr19:9415943_9415946delACAC	uc002mlc.1	-							NM_198535	NP_940937	Q32M78	ZN699_HUMAN	zinc finger protein 699						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAAAacacatacacacacacacac	0.377													---	---	---								-	9415946	-	-	9415943	6	5	226	0	1	1	0	1	0	0	0	0	18168	406	14	0		0	ZNF699	19	9415943	5'Flank	DEL	ACAC	TCGA-CV-7104-01A-11D-2012-08	367479	9415943	49713040	115	41460											
ZNF791	163049	broad.mit.edu	37	chr19	12734543	12734543	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttttgaggatgtgtctgtGagcttcagccaggaggagtg	7	12	16	6	0	2	2	1	2	1	0	2	5	2	5	1	3	2	2	1	3	0	3			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr19:12734543G>C	uc002mua.2	+	2	195	c.33G>C	c.(31-33)GTG>GTC	p.V11V	ZNF791_uc010xml.1_5'UTR|ZNF791_uc010dyu.1_5'UTR|ZNF791_uc010xmm.1_Intron	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	11	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ATGTGTCTGTGAGCTTCAGCC	0.443													4	132					0	0	0	0	C	12734543	C	C	12734543	2	2	226	1	0	0	0	0	0	0	0	1	18230	1277	45	2		2	ZNF791	19	12734543	Silent	SNP	G	TCGA-CV-7104-01A-11D-2012-08	3318600	12734543	46394440	116	41461											
TNPO2	30000	broad.mit.edu	37	chr19	12822400	12822400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtcaatttccgagtacttCatcccattcaccaagatggg	11	12	7	11	1	3	1	3	0	0	1	5	2	5	1	3	1	1	1	3	1	3	4			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr19:12822400C>T	uc002muo.2	-	10	1103	c.918G>A	c.(916-918)ATG>ATA	p.M306I	TNPO2_uc002mup.2_Missense_Mutation_p.M398I|TNPO2_uc002muq.2_Missense_Mutation_p.M306I|TNPO2_uc002mur.2_Missense_Mutation_p.M306I	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	306	HEAT 5.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						CCGAGTACTTCATCCCATTCA	0.592													7	25					0	0	0	0	T	12822400	T	T	12822400	3	4	226	1	0	0	0	0	1	0	0	0	16402	826	29	2	1835	2	TNPO2	19	12822400	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	87857	12822400	46306583	117	41462											
ZNF790	388536	broad.mit.edu	37	chr19	37309438	37309438	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tattctggtgttgagcaaagTttgactcatgactaaaggtg	11	14	11	5	0	2	3	1	3	1	0	2	3	2	3	0	2	1	3	0	2	4	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr19:37309438T>A	uc002oew.2	-	5	1927	c.1808A>T	c.(1807-1809)AAC>ATC	p.N603I	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	603					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TTGAGCAAAGTTTGACTCATG	0.323													34	94					0	0	0	0	A	37309438	A	A	37309438	3	1	226	1	0	0	0	0	1	0	0	0	18229	1725	60	5	106	5	ZNF790	19	37309438	Missense_Mutation	SNP	T	TCGA-CV-7104-01A-11D-2012-08	24487038	37309438	21819545	118	41463											
GRIN2D	2906	broad.mit.edu	37	chr19	48945466	48945466	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctgccacaatgacaaaatcGaggtgatgagcagcaagctg	14	7	11	9	1	1	3	0	3	1	0	2	4	1	3	1	1	4	3	1	1	4	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr19:48945466G>A	uc002pjc.3	+	12	2588	c.2500G>A	c.(2500-2502)GAG>AAG	p.E834K	GRIN2D_uc010elx.2_Missense_Mutation_p.E69K	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	834	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	TGACAAAATCGAGGTGATGAG	0.577													49	124					0	0	0	0	A	48945466	A	A	48945466	3	1	226	1	0	0	0	0	1	0	0	0	6821	1059	37	1	2542	1	GRIN2D	19	48945466	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	11636028	48945466	10183517	119	41464											
ZBTB45	84878	broad.mit.edu	37	chr19	59028060	59028060	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggggaagagtgcaacgggCggccctggggtcttcacacc	9	5	16	11	2	2	1	1	0	1	1	2	2	2	2	2	6	2	1	2	6	3	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr19:59028060C>T	uc002qtd.2	-	2	1273	c.981G>A	c.(979-981)CCG>CCA	p.P327P	ZBTB45_uc002qte.2_Silent_p.P327P|ZBTB45_uc002qtf.2_Silent_p.P327P	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	327	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		GTGCAACGGGCGGCCCTGGGG	0.692													12	20					0	0	0	0	T	59028060	T	T	59028060	2	4	226	1	0	0	0	0	0	0	0	1	17613	755	27	1		1	ZBTB45	19	59028060	Silent	SNP	C	TCGA-CV-7104-01A-11D-2012-08	10082594	59028060	100923	120	41465											
ITPA	3704	broad.mit.edu	37	chr20	3193868	3193868	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttggtggcacagaaaatTgaccgtatgtctctgttttg	9	15	10	7	1	1	2	0	1	1	1	2	2	1	2	1	2	0	3	1	2	3	5			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr20:3193868T>G	uc002wid.2	+	2	262	c.120T>G	c.(118-120)ATT>ATG	p.I40M	ITPA_uc002wie.2_Missense_Mutation_p.I23M|ITPA_uc002wif.2_Intron	NM_033453	NP_258412	Q9BY32	ITPA_HUMAN	inosine triphosphatase isoform a	40					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			ovary(1)	1						CACAGAAAATTGACCGTATGT	0.403													25	51					0	0	0	0	G	3193868	G	G	3193868	3	3	226	1	0	0	0	0	1	0	0	0	7954	1800	63	5	126	5	ITPA	20	3193868	Missense_Mutation	SNP	T	TCGA-CV-7104-01A-11D-2012-08		3193868	59831652	121	41466											
SLC32A1	140679	broad.mit.edu	37	chr20	37357005	37357005	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaagtcctgggggctgaCgctgcgctgcgcgctcgtcg	3	8	16	14	6	0	2	0	2	0	0	3	2	1	2	2	2	2	4	2	2	1	0			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr20:37357005C>T	uc002xjc.2	+	2	1564	c.1301C>T	c.(1300-1302)ACG>ATG	p.T434M		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	434	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TGGGGGCTGACGCTGCGCTGC	0.682													14	41					0	0	0	0	T	37357005	T	T	37357005	3	4	226	1	0	0	0	0	1	0	0	0	14629	536	19	1	1307	1	SLC32A1	20	37357005	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08	34163137	37357005	25668515	122	41467											
INPP5J	27124	broad.mit.edu	37	chr22	31520883	31520883	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaacgcagccctaggaccctCggaaccaaggttggctctgg	9	6	13	13	2	1	0	0	0	1	0	2	3	1	2	3	5	3	3	3	5	4	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr22:31520883C>T	uc003aju.3	+	2	250	c.158C>T	c.(157-159)TCG>TTG	p.S53L	INPP5J_uc010gwf.2_Missense_Mutation_p.S53L|INPP5J_uc003ajv.3_5'UTR|INPP5J_uc003ajs.3_5'UTR|INPP5J_uc011alk.1_5'UTR|INPP5J_uc010gwg.2_Intron|INPP5J_uc003ajw.2_Intron|INPP5J_uc003ajt.3_Missense_Mutation_p.S53L|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	53						cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						CTAGGACCCTCGGAACCAAGG	0.572													11	34					0	0	0	0	T	31520883	T	T	31520883	3	4	226	1	0	0	0	0	1	0	0	0	7798	893	31	1	164	1	INPP5J	22	31520883	Missense_Mutation	SNP	C	TCGA-CV-7104-01A-11D-2012-08		31520883	19783683	123	41468											
EIF3L	51386	broad.mit.edu	37	chr22	38258977	38258977	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctcttgttttctttacaggGgggaccttccttggagcaga	6	15	11	9	0	2	1	0	0	2	1	4	3	3	3	2	4	2	2	2	4	1	7			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chr22:38258977G>A	uc003auf.2	+	6	524	c.437G>A	c.(436-438)GGG>GAG	p.G146E	EIF3L_uc003aue.1_Missense_Mutation_p.G146E|EIF3L_uc011ann.1_Intron|EIF3L_uc003aug.2_Missense_Mutation_p.G38E	NM_016091	NP_057175	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3	146						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1						TCTTTACAGGGGGGACCTTCC	0.383													19	48					0	0	0	0	A	38258977	A	A	38258977	3	1	226	1	0	0	0	0	1	0	0	0	5046	1246	43	4	459	4	EIF3L	22	38258977	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	6738094	38258977	13045589	124	41469											
BCOR	54880	broad.mit.edu	37	chrX	39932420	39932420	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgtgtgtggtatcaacatggGatgcaccatgcccaacccca	10	8	10	13	1	1	0	1	0	0	0	1	1	1	1	4	2	4	2	4	2	3	1			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chrX:39932420G>T	uc004den.3	-	4	2471	c.2179C>A	c.(2179-2181)CCC>ACC	p.P727T	BCOR_uc004dep.3_Missense_Mutation_p.P727T|BCOR_uc004deo.3_Missense_Mutation_p.P727T|BCOR_uc004dem.3_Missense_Mutation_p.P727T|BCOR_uc004deq.3_Missense_Mutation_p.P727T	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	727					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						ATCAACATGGGATGCACCATG	0.582													30	56					6.38683e-12	3.70832e-11	1	0	T	39932420	T	T	39932420	3	4	226	1	0	0	0	0	1	0	0	0	1388	1174	41	2	3136	2	BCOR	23	39932420	Missense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08		39932420	115338140	125	41470											
DGKK	139189	broad.mit.edu	37	chrX	50119800	50119800	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgagctaagtgctgcatctGggcatactcctcgtcagaga	9	9	11	12	2	2	1	1	0	1	1	4	3	3	1	2	1	4	4	2	1	2	2			TCGA-CV-7104-01A-11D-2012-08	TCGA-CV-7104-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f429401-f71e-4908-9663-2e66bacbebdd	b0f2c7dd-277a-4b14-af9d-0d07c789508a	g.chrX:50119800G>A	uc010njr.1	-	24	3289	c.3229C>T	c.(3229-3231)CAG>TAG	p.Q1077*		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	1077					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TGCTGCATCTGGGCATACTCC	0.502													8	10					0	0	0	0	A	50119800	A	A	50119800	4	1	226	1	0	0	0	0	0	1	0	0	4494	1357	47	4	610	4	DGKK	23	50119800	Nonsense_Mutation	SNP	G	TCGA-CV-7104-01A-11D-2012-08	10187380	50119800	105150760	126	41471											
UTS2	10911	broad.mit.edu	37	chr1	7913185	7913185	+	5'Flank	DEL	A	-	-																															gacctgacatcatcctctccAaaaaaaaaaaaaaaatgaat																								rs34962249		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:7913185delA	uc001aor.2	-						UTS2_uc001aoq.2_Intron|UTS2_uc001aos.2_Intron	NM_006786	NP_006777	O95399	UTS2_HUMAN	urotensin 2 isoform b preproprotein						muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity				0	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		CATCCTCTCCAAAAAAAAAAA	0.338													---	---	---								-	7913185	-	-	7913185	6	5	227	0	1	1	0	1	0	0	0	0	17172	145	5	0		0	UTS2	1	7913185	5'Flank	DEL	A	TCGA-CV-7177-01A-11D-2012-08		7913185	241337436	1	41472											
AADACL4	343066	broad.mit.edu	37	chr1	12726525	12726525	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagatgatgaggtcatcgctCagcttcctgaggccttcctg	7	11	11	12	1	2	4	2	3	0	1	5	4	4	4	3	2	1	2	3	2	0	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:12726525C>G	uc001auf.2	+	4	1003	c.1003C>G	c.(1003-1005)CAG>GAG	p.Q335E		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	335	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GGTCATCGCTCAGCTTCCTGA	0.517													10	106					0	0	0	0	G	12726525	G	G	12726525	3	3	227	1	0	0	0	0	1	0	0	0	13	827	29	2	1017	2	AADACL4	1	12726525	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	4813340	12726525	236524096	2	41473											
PRAMEF12	390999	broad.mit.edu	37	chr1	12837210	12837210	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgaatgcctgctgtcagagtCggacctgaagcatctctctt	8	11	10	12	2	3	2	1	1	2	1	5	4	3	3	2	1	3	2	2	1	2	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:12837210C>G	uc001aui.2	+	3	947	c.920C>G	c.(919-921)TCG>TGG	p.S307W		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	307										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGTCAGAGTCGGACCTGAAG	0.557													45	127					0	0	0	0	G	12837210	G	G	12837210	3	3	227	1	0	0	0	0	1	0	0	0	12488	893	31	3	930	3	PRAMEF12	1	12837210	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	110685	12837210	236413411	3	41474											
PDPN	10630	broad.mit.edu	37	chr1	13936917	13936917	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagtgtaacaggcattcgCatcgaggatctgccaacttc	12	9	9	11	2	1	0	0	0	1	0	4	2	1	1	1	2	4	3	1	2	3	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:13936917C>A	uc001avd.2	+	3	514	c.465C>A	c.(463-465)CGC>CGA	p.R155R	PDPN_uc001avc.2_Silent_p.R155R|PDPN_uc009vob.2_Silent_p.R37R|PDPN_uc009voc.2_Silent_p.R37R|PDPN_uc001ave.2_Silent_p.R37R|PDPN_uc001avf.2_Silent_p.R37R	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	79	Extracellular (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		CAGGCATTCGCATCGAGGATC	0.473													4	66					0.00909568	0.00986433	1	0	A	13936917	A	A	13936917	2	1	227	1	0	0	0	0	0	0	0	1	11742	697	25	4		4	PDPN	1	13936917	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	1099707	13936917	235313704	4	41475											
PEF1	553115	broad.mit.edu	37	chr1	32098207	32098207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctgagaagccgtagacatCgatgcggcctgacttggtct	8	9	14	10	3	1	3	0	2	1	2	2	5	1	3	2	3	2	2	2	3	2	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:32098207C>T	uc001bth.1	-	4	526	c.514G>A	c.(514-516)GAT>AAT	p.D172N	PEF1_uc001bte.1_Missense_Mutation_p.D11N|PEF1_uc001btf.1_Missense_Mutation_p.D11N|PEF1_uc001btg.1_Missense_Mutation_p.D102N	NM_012392	NP_036524	Q9UBV8	PEF1_HUMAN	penta-EF-hand domain containing 1	172	EF-hand 2.				response to calcium ion	cytoplasm|membrane	calcium ion binding|protein heterodimerization activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)|all_neural(195;0.186)		STAD - Stomach adenocarcinoma(196;0.0546)		CCGTAGACATCGATGCGGCCT	0.557													14	32					0	0	0	0	T	32098207	T	T	32098207	3	4	227	1	0	0	0	0	1	0	0	0	11772	884	31	1	348	1	PEF1	1	32098207	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	18161290	32098207	217152414	5	41476											
SYDE2	84144	broad.mit.edu	37	chr1	85666170	85666170	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcctggcggtctcctttGccactgcgtatcacagagga	6	11	10	14	2	2	1	1	0	1	1	4	2	3	2	4	3	2	1	4	3	1	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:85666170G>A	uc009wcm.2	-	1	559	c.510C>T	c.(508-510)GGC>GGT	p.G170G	SYDE2_uc001dku.3_Silent_p.G170G	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	170					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		GGTCTCCTTTGCCACTGCGTA	0.642													31	51					0	0	0	0	A	85666170	A	A	85666170	2	1	227	1	0	0	0	0	0	0	0	1	15502	1306	46	4		4	SYDE2	1	85666170	Silent	SNP	G	TCGA-CV-7177-01A-11D-2012-08	53567963	85666170	163584451	6	41477											
DENND2D	79961	broad.mit.edu	37	chr1	111730992	111730992	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctcgttgatttgttctgcaGctgcaggagatataaaggcc	9	12	12	8	1	1	2	0	1	1	1	2	3	1	2	1	2	3	6	1	2	3	5			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:111730992G>C	uc001eak.1	-	11	1300	c.1100C>G	c.(1099-1101)ACT>AGT	p.T367S	DENND2D_uc001eal.1_Missense_Mutation_p.T364S	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	367										ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		TTGTTCTGCAGCTGCAGGAGA	0.483													20	44					0	0	0	0	C	111730992	C	C	111730992	3	2	227	1	0	0	0	0	1	0	0	0	4453	985	34	4	323	4	DENND2D	1	111730992	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	26064822	111730992	137519629	7	41478											
LINGO4	339398	broad.mit.edu	37	chr1	151774300	151774300	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaccagggggctgagccttCgggctgggatggctgagatg	6	7	19	9	1	0	2	0	2	0	1	1	4	0	3	2	5	1	4	2	5	0	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:151774300C>T	uc001ezf.1	-	2	1071	c.881G>A	c.(880-882)CGA>CAA	p.R294Q		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	294	Extracellular (Potential).|LRR 9.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCTGAGCCTTCGGGCTGGGAT	0.622													22	56					0	0	0	0	T	151774300	T	T	151774300	3	4	227	1	0	0	0	0	1	0	0	0	8859	884	31	1	904	1	LINGO4	1	151774300	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	40043308	151774300	97476321	8	41479											
FLG	2312	broad.mit.edu	37	chr1	152285104	152285104	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgtctgagtcttctgaaTgtccctcactgtcagtggcc	5	14	11	11	0	5	2	2	2	3	0	6	2	6	2	2	1	0	0	2	1	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:152285104T>A	uc001ezu.1	-	3	2294	c.2258A>T	c.(2257-2259)CAT>CTT	p.H753L	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	753	Filaggrin 4.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCTTCTGAATGTCCCTCACT	0.582									Ichthyosis				15	785					0	0	0	0	A	152285104	A	A	152285104	3	1	227	1	0	0	0	0	1	0	0	0	5954	1464	51	5	9931	5	FLG	1	152285104	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	510804	152285104	96965517	9	41480											
IQGAP3	128239	broad.mit.edu	37	chr1	156532415	156532415	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgccctggatttcagcctGagttaggtagtggtcataga	9	13	12	7	0	2	2	2	1	0	1	2	3	2	3	2	3	2	2	2	3	3	5			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:156532415G>C	uc001fpf.2	-	9	916	c.841C>G	c.(841-843)CAG>GAG	p.Q281E	IQGAP3_uc009wsb.1_Missense_Mutation_p.Q238E	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	281					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATTTCAGCCTGAGTTAGGTAG	0.507													49	135					0	0	0	0	C	156532415	C	C	156532415	3	2	227	1	0	0	0	0	1	0	0	0	7855	1299	45	2	4174	2	IQGAP3	1	156532415	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	4247311	156532415	92718206	10	41481											
OR10X1	128367	broad.mit.edu	37	chr1	158548862	158548862	+	Frame_Shift_Del	DEL	C	-	-																															tctcctgaggcttctggcttCaaataaacaatagatgcaaa																										TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:158548862delC	uc010pin.1	-	1	828	c.828delG	c.(826-828)TTGfs	p.L276fs		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	276	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CTTCTGGCTTCAAATAAACAA	0.493													---	---	---								-	158548862	-	-	158548862	7	5	227	1	0	1	0	1	0	0	0	0	10976	825	29	0	147	0	OR10X1	1	158548862	Frame_Shift_Del	DEL	C	TCGA-CV-7177-01A-11D-2012-08	2016447	158548862	90701759	11	41482											
ATP2B4	493	broad.mit.edu	37	chr1	203678644	203678644	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcttccgtatgtacagcaaGggcgcctctgagatcatctt	8	11	11	11	2	3	1	1	1	2	1	4	2	4	1	2	2	2	4	2	2	3	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:203678644G>C	uc001gzw.2	+	11	2657	c.1773G>C	c.(1771-1773)AAG>AAC	p.K591N	ATP2B4_uc001gzv.2_Missense_Mutation_p.K591N|ATP2B4_uc009xaq.2_Missense_Mutation_p.K591N	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	591	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGTACAGCAAGGGCGCCTCTG	0.557													7	74					0	0	0	0	C	203678644	C	C	203678644	3	2	227	1	0	0	0	0	1	0	0	0	1144	991	35	4	1811	4	ATP2B4	1	203678644	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	45129782	203678644	45571977	12	41483											
LYST	1130	broad.mit.edu	37	chr1	235972380	235972385	+	In_Frame_Del	DEL	TGTTAT	-	-																															catacaacagcatattccaaTgttatgaacacccgatagga																										TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:235972380_235972385delTGTTAT	uc001hxj.2	-	5	1908_1913	c.1733_1738delATAACA	c.(1732-1740)CATAACATT>CTT	p.578_580HNI>L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_In_Frame_Del_p.578_580HNI>L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	578_580					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CATATTCCAATGTTATGAACACCCGA	0.442									Chediak-Higashi_syndrome				---	---	---								-	235972385	-	-	235972380	7	5	227	1	0	1	0	1	0	0	0	0	9179	1464	51	0	9863	0	LYST	1	235972380	In_Frame_Del	DEL	TGTTAT	TCGA-CV-7177-01A-11D-2012-08	32293736	235972380	13278241	13	41484											
OR2L2	26246	broad.mit.edu	37	chr1	248201955	248201955	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggccatttgctttcctcTccactatcccatccgtataa	7	15	5	14	1	1	0	0	0	1	0	5	0	4	0	5	1	1	2	5	1	3	5			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:248201955T>C	uc001idw.2	+	1	482	c.386T>C	c.(385-387)CTC>CCC	p.L129P	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGCTTTCCTCTCCACTATCCC	0.408													6	179					0	0	0	0	C	248201955	C	C	248201955	3	2	227	1	0	0	0	0	1	0	0	0	11061	1551	54	5	388	5	OR2L2	1	248201955	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	12229575	248201955	1048666	14	41485											
EPAS1	2034	broad.mit.edu	37	chr2	46605175	46605175	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accgtgccccaggcagctgcCccgggcagcaccacccccag	7	2	11	21	2	0	0	0	0	0	0	0	0	0	0	8	2	4	4	8	2	0	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:46605175C>T	uc002ruv.2	+	10	1880	c.1392C>T	c.(1390-1392)GCC>GCT	p.A464A	EPAS1_uc002ruw.2_5'Flank	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	464					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			AGGCAGCTGCCCCGGGCAGCA	0.682													3	11					0	0	0	0	T	46605175	T	T	46605175	2	4	227	1	0	0	0	0	0	0	0	1	5174	610	22	4		4	EPAS1	2	46605175	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08		46605175	196594198	15	41486											
CCDC88A	55704	broad.mit.edu	37	chr2	55528370	55528370	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgatcccgtactagaatcAtcactaacaccttgtggact	11	12	6	12	1	2	2	2	1	0	1	3	3	3	3	2	1	2	1	2	1	4	5			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:55528370A>T	uc002ryv.2	-	28	5555	c.4713T>A	c.(4711-4713)GAT>GAA	p.D1571E	CCDC88A_uc010yoz.1_Missense_Mutation_p.D1544E|CCDC88A_uc010ypa.1_Missense_Mutation_p.D1571E|CCDC88A_uc010fbw.2_Missense_Mutation_p.D100E|CCDC88A_uc002ryu.2_Missense_Mutation_p.D826E|CCDC88A_uc002rys.2_Missense_Mutation_p.D529E|CCDC88A_uc002ryw.2_Missense_Mutation_p.D855E|CCDC88A_uc010fby.1_Missense_Mutation_p.D423E	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1572					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TACTAGAATCATCACTAACAC	0.308													7	24					0	0	0	0	T	55528370	T	T	55528370	3	4	227	1	0	0	0	0	1	0	0	0	2876	214	8	5	919	5	CCDC88A	2	55528370	Missense_Mutation	SNP	A	TCGA-CV-7177-01A-11D-2012-08	8923195	55528370	187671003	16	41487											
FBXO48	554251	broad.mit.edu	37	chr2	68691399	68691400	+	Frame_Shift_Del	DEL	AT	-	-																															tatctgcatccattgggtacAtgattttttctggtaggcta																										TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:68691399_68691400delAT	uc002seo.2	-	4	817_818	c.409_410delAT	c.(409-411)ATGfs	p.M137fs		NM_001024680	NP_001019851	Q5FWF7	FBX48_HUMAN	F-box protein 48	137											0						CATTGGGTACATGATTTTTTCT	0.391													---	---	---								-	68691400	-	-	68691399	7	5	227	1	0	1	0	1	0	0	0	0	5789	217	8	0	61	0	FBXO48	2	68691399	Frame_Shift_Del	DEL	AT	TCGA-CV-7177-01A-11D-2012-08	13163029	68691399	174507974	17	41488											
INPP4A	3631	broad.mit.edu	37	chr2	99156130	99156130	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctcctactagaggaagaTgcagccaggtgaggccacat	13	6	12	10	0	0	3	0	1	0	2	1	4	1	4	3	3	4	2	3	3	4	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:99156130T>A	uc002syy.2	+	10	1203	c.810T>A	c.(808-810)GAT>GAA	p.D270E	INPP4A_uc010yvj.1_Missense_Mutation_p.D270E|INPP4A_uc010yvk.1_Missense_Mutation_p.D270E|INPP4A_uc002syx.2_Missense_Mutation_p.D270E|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	270					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						TAGAGGAAGATGCAGCCAGGT	0.483													3	46					0	0	0	0	A	99156130	A	A	99156130	3	1	227	1	0	0	0	0	1	0	0	0	7791	1461	51	5	840	5	INPP4A	2	99156130	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	30464731	99156130	144043243	18	41489											
SCN3A	6328	broad.mit.edu	37	chr2	166032739	166032739	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tggaaggttctttccagcttCcaagtcactatttggctttg	7	16	9	9	0	2	0	1	0	1	0	4	1	4	1	2	3	1	3	2	3	3	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:166032739C>G	uc002ucx.2	-	3	658	c.166G>C	c.(166-168)GAA>CAA	p.E56Q	SCN3A_uc002ucy.2_Missense_Mutation_p.E56Q|SCN3A_uc002ucz.2_Missense_Mutation_p.E56Q	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	56						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTTCCAGCTTCCAAGTCACTA	0.428													4	119					0	0	0	0	G	166032739	G	G	166032739	3	3	227	1	0	0	0	0	1	0	0	0	13983	864	30	2	6036	2	SCN3A	2	166032739	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	66876609	166032739	77166634	19	41490											
NFE2L2	4780	broad.mit.edu	37	chr2	178098810	178098810	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggagaaattcacctgtctCttcatctagttgtaactgag	10	14	9	8	0	4	2	2	1	2	1	5	3	4	2	1	1	1	2	1	1	3	5			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:178098810C>G	uc002ulh.3	-	2	790	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63Q|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63Q|NFE2L2_uc002uli.3_Missense_Mutation_p.E63Q|NFE2L2_uc010fra.2_Missense_Mutation_p.E63Q|NFE2L2_uc010frb.2_Missense_Mutation_p.E63Q	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			20	43					0	0	0	0	G	178098810	G	G	178098810	3	3	227	1	0	0	0	0	1	0	0	0	10422	922	32	2	1598	2	NFE2L2	2	178098810	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	12066071	178098810	65100563	20	41491											
GRM7	2917	broad.mit.edu	37	chr3	6903352	6903352	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggaccagatcaacagtgatCccaacctactgcccaacgtg	12	7	8	14	1	1	2	1	1	0	1	2	3	2	3	4	1	5	0	4	1	4	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:6903352C>T	uc003bqm.2	+	1	551	c.277C>T	c.(277-279)CCC>TCC	p.P93S	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.P93S|GRM7_uc003bql.2_Missense_Mutation_p.P93S	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	93	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CAACAGTGATCCCAACCTACT	0.607													11	7					0	0	0	0	T	6903352	T	T	6903352	3	4	227	1	0	0	0	0	1	0	0	0	6841	855	30	2	279	2	GRM7	3	6903352	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08		6903352	191119078	21	41492											
USP19	10869	broad.mit.edu	37	chr3	49148936	49148936	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttcactggatcttaccttCgggtcgggacaccctctcgc	5	12	9	15	3	3	0	1	0	2	0	6	2	3	2	2	3	1	0	2	3	1	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:49148936C>T	uc003cwd.1	-	20	3066	c.2905G>A	c.(2905-2907)GAA>AAA	p.E969K	USP19_uc003cwa.2_Missense_Mutation_p.E777K|USP19_uc003cvz.3_Missense_Mutation_p.E1072K|USP19_uc011bcg.1_Missense_Mutation_p.E1060K|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_Missense_Mutation_p.E727K|USP19_uc011bch.1_Missense_Mutation_p.E1070K	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	969	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATCTTACCTTCGGGTCGGGAC	0.607													17	17					0	0	0	0	T	49148936	T	T	49148936	3	4	227	1	0	0	0	0	1	0	0	0	17118	893	31	1	1079	1	USP19	3	49148936	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	42245584	49148936	148873494	22	41493											
BBX	56987	broad.mit.edu	37	chr3	107497345	107497345	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agactggaaatgtgtcctcaGaaccgactaaaaccagcaaa	17	6	8	10	1	1	2	1	0	0	2	2	4	2	3	3	1	3	1	3	1	5	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:107497345G>T	uc010hpr.2	+	13	2509	c.2182G>T	c.(2182-2184)GAA>TAA	p.E728*	BBX_uc003dwk.3_Nonsense_Mutation_p.E728*|BBX_uc003dwl.3_Missense_Mutation_p.Q391H|BBX_uc003dwm.3_Nonsense_Mutation_p.E728*|BBX_uc003dwo.3_Missense_Mutation_p.Q77H	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	728	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			TGTGTCCTCAGAACCGACTAA	0.438													5	71					3.59834e-05	4.10477e-05	1	0	T	107497345	T	T	107497345	4	4	227	1	0	0	0	0	0	1	0	0	1345	943	33	2	2220	2	BBX	3	107497345	Nonsense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	58348409	107497345	90525085	23	41494											
ADCY5	111	broad.mit.edu	37	chr3	123167254	123167254	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagccgcgggcagagccccCgggggcatgggggtagccat	6	3	20	12	3	0	1	0	0	0	1	0	2	0	2	4	6	3	3	4	6	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr3:123167254C>G	uc003egh.1	-	1	139	c.139G>C	c.(139-141)GGG>CGG	p.G47R		NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	47	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GCAGAGCCCCCGGGGGCATGG	0.632													5	7					0	0	0	0	G	123167254	G	G	123167254	3	3	227	1	0	0	0	0	1	0	0	0	297	652	23	3	3730	3	ADCY5	3	123167254	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	15669909	123167254	74855176	24	41495											
PLXND1	23129	broad.mit.edu	37	chr3	129281955	129281955	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acccggggcttggcctcgatGttctcccgcagcagccactc	5	8	11	17	3	1	0	0	0	1	0	4	1	1	0	4	3	2	4	4	3	0	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:129281955G>T	uc003emx.2	-	26	4750	c.4650C>A	c.(4648-4650)AAC>AAA	p.N1550K	PLXND1_uc011blb.1_Missense_Mutation_p.N218K	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1550	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGGCCTCGATGTTCTCCCGCA	0.637													17	23					3.45872e-05	4.00483e-05	1	0	T	129281955	T	T	129281955	3	4	227	1	0	0	0	0	1	0	0	0	12182	1368	48	4	1171	4	PLXND1	3	129281955	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	6114701	129281955	68740475	25	41496											
AADAC	13	broad.mit.edu	37	chr3	151545495	151545495	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctatttctatccaaatcactCatggtcagattctggagtga	11	14	7	9	0	5	2	3	1	2	1	6	3	6	3	1	2	0	0	1	2	3	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:151545495C>G	uc003eze.2	+	5	825	c.735C>G	c.(733-735)CTC>CTG	p.L245L		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	245	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CCAAATCACTCATGGTCAGAT	0.363													19	58					0	0	0	0	G	151545495	G	G	151545495	2	3	227	1	0	0	0	0	0	0	0	1	10	813	29	2		2	AADAC	3	151545495	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	22263540	151545495	46476935	26	41497											
PLCH1	23007	broad.mit.edu	37	chr3	155200527	155200527	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttttccttgattttcacAccatgcagatcttgtgtggg	6	16	8	11	0	2	2	1	1	1	1	3	2	3	2	3	1	1	1	3	1	0	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:155200527A>G	uc011bok.1	-	23	3589	c.3312T>C	c.(3310-3312)GGT>GGC	p.G1104G	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.G1066G	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1104					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGATTTTCACACCATGCAGAT	0.473													49	170					0	0	0	0	G	155200527	G	G	155200527	2	3	227	1	0	0	0	0	0	0	0	1	12092	146	6	5		5	PLCH1	3	155200527	Silent	SNP	A	TCGA-CV-7177-01A-11D-2012-08	3655032	155200527	42821903	27	41498											
NLGN1	22871	broad.mit.edu	37	chr3	173997073	173997073	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttatatggatatcctgaaGgcaaagatgttttgagagaa	15	13	10	3	0	0	4	0	2	0	2	1	6	1	5	1	2	0	2	1	2	6	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:173997073G>C	uc003fio.1	+	6	1705	c.1282G>C	c.(1282-1284)GGC>CGC	p.G428R	NLGN1_uc010hww.1_Missense_Mutation_p.G468R|NLGN1_uc003fip.1_Missense_Mutation_p.G428R	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	445	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			ATATCCTGAAGGCAAAGATGT	0.343													6	90					0	0	0	0	C	173997073	C	C	173997073	3	2	227	1	0	0	0	0	1	0	0	0	10515	1000	35	4	1296	4	NLGN1	3	173997073	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	18796546	173997073	24025357	28	41499											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	65					0	0	0	0	A	178936091	A	A	178936091	3	1	227	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	4939018	178936091	19086339	29	41500											
WDFY3	23001	broad.mit.edu	37	chr4	85752750	85752750	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaacaaaactgcacagtttCactaagatctaaaaaataaa	22	8	4	7	0	2	1	1	0	1	1	2	2	2	1	0	0	3	2	0	0	9	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr4:85752750C>T	uc003hpd.2	-	8	993	c.585G>A	c.(583-585)GTG>GTA	p.V195V	WDFY3_uc003hpf.2_Silent_p.V195V	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	195						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TGCACAGTTTCactaagatct	0.249													18	41					0	0	0	0	T	85752750	T	T	85752750	2	4	227	1	0	0	0	0	0	0	0	1	17338	813	29	2		2	WDFY3	4	85752750	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08		85752750	105401526	30	41501											
SLC39A8	64116	broad.mit.edu	37	chr4	103226195	103226195	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcattctttcaaaaaagaaaAgtaggtaaaatccaccaaac	20	8	5	8	0	2	1	1	0	1	1	3	1	3	1	2	1	1	3	2	1	9	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr4:103226195A>T	uc003hwb.1	-	4	1155	c.626T>A	c.(625-627)CTT>CAT	p.L209H	SLC39A8_uc011ceo.1_Missense_Mutation_p.L209H|SLC39A8_uc003hwa.1_Missense_Mutation_p.L142H|SLC39A8_uc003hwc.2_Missense_Mutation_p.L209H	NM_022154	NP_071437	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter),	209	Helical; (Potential).					integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		AAAAAAGAAAAGTAGGTAAAA	0.348													6	32					0	0	0	0	T	103226195	T	T	103226195	3	4	227	1	0	0	0	0	1	0	0	0	14688	72	3	5	853	5	SLC39A8	4	103226195	Missense_Mutation	SNP	A	TCGA-CV-7177-01A-11D-2012-08	17473445	103226195	87928081	31	41502											
ARSJ	79642	broad.mit.edu	37	chr4	114823767	114823767	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccatacacttttgccagttGacaaggtgatccgttcattg	9	13	9	10	1	1	2	1	2	0	0	2	2	2	2	3	1	2	2	3	1	2	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr4:114823767G>C	uc003ibq.1	-	2	2351	c.1463C>G	c.(1462-1464)TCA>TGA	p.S488*	ARSJ_uc010imu.1_Nonsense_Mutation_p.S488*|ARSJ_uc010imv.1_Nonsense_Mutation_p.S316*	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	488						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		TTTGCCAGTTGACAAGGTGAT	0.512													33	61					0	0	0	0	C	114823767	C	C	114823767	4	2	227	1	0	0	0	0	0	1	0	0	997	1294	45	2	340	2	ARSJ	4	114823767	Nonsense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	11597572	114823767	76330509	32	41503											
ADAM29	11086	broad.mit.edu	37	chr4	175897109	175897109	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccctagcattttctaccacgTttgaacatctggtatacaag	11	13	6	11	1	2	1	0	1	2	0	2	1	2	1	2	1	4	3	2	1	6	7			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr4:175897109T>A	uc003iuc.2	+	5	1103	c.433T>A	c.(433-435)TTT>ATT	p.F145I	ADAM29_uc003iud.2_Missense_Mutation_p.F145I|ADAM29_uc010irr.2_Missense_Mutation_p.F145I|ADAM29_uc011cki.1_Missense_Mutation_p.F145I	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	145					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TTCTACCACGTTTGAACATCT	0.383													16	44					0	0	0	0	A	175897109	A	A	175897109	3	1	227	1	0	0	0	0	1	0	0	0	247	1725	60	5	435	5	ADAM29	4	175897109	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	61073342	175897109	15257167	33	41504											
TTC23L	153657	broad.mit.edu	37	chr5	34845770	34845770	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagtagctcagctgattaagGaaaaaatggtaaaacaaaaa	22	7	8	4	0	1	1	1	1	0	0	1	2	1	2	0	2	3	4	0	2	10	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr5:34845770G>A	uc003jiu.2	+	3	350	c.247G>A	c.(247-249)GAA>AAA	p.E83K		NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	83	Potential.						binding			central_nervous_system(1)	1						GCTGATTAAGGAAAAAATGGT	0.358													3	28					0	0	0	0	A	34845770	A	A	34845770	3	1	227	1	0	0	0	0	1	0	0	0	16759	1175	41	2	253	2	TTC23L	5	34845770	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08		34845770	146069490	34	41505											
PWWP2A	114825	broad.mit.edu	37	chr5	159520157	159520157	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggcttgggtgccatcttGccactccgcattttctcaag	5	13	11	12	1	2	0	1	0	2	0	4	0	3	0	3	3	2	2	3	3	1	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr5:159520157G>C	uc011ded.1	-	2	1557	c.1500C>G	c.(1498-1500)GGC>GGG	p.G500G	PWWP2A_uc003lxv.3_Silent_p.G500G|PWWP2A_uc011dec.1_Silent_p.G500G	NM_001130864	NP_001124336	Q96N64	PWP2A_HUMAN	PWWP domain containing 2A isoform b	500											0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTGCCATCTTGCCACTCCGCA	0.537													5	21					0	0	0	0	C	159520157	C	C	159520157	2	2	227	1	0	0	0	0	0	0	0	1	12910	1306	46	4		4	PWWP2A	5	159520157	Silent	SNP	G	TCGA-CV-7177-01A-11D-2012-08	124674387	159520157	21395103	35	41506											
JARID2	3720	broad.mit.edu	37	chr6	15501599	15501599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggtcaaggaagaggaggagGacaaaggcgtcctcaatgac	14	5	15	7	1	2	2	2	1	0	1	3	6	3	6	1	6	0	0	1	6	4	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:15501599G>A	uc003nbj.2	+	8	2651	c.2407G>A	c.(2407-2409)GAC>AAC	p.D803N	JARID2_uc011div.1_Missense_Mutation_p.D631N|JARID2_uc011diw.1_Missense_Mutation_p.D765N	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	803					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGAGGAGGAGGACAAAGGCGT	0.587													5	27					0	0	0	0	A	15501599	A	A	15501599	3	1	227	1	0	0	0	0	1	0	0	0	7984	1174	41	2	2437	2	JARID2	6	15501599	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08		15501599	155613468	36	41507											
HIST1H3B	8358	broad.mit.edu	37	chr6	26032187	26032187	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtgaggctttttcacgccGccggtagccggcgcgctctt	3	10	14	14	7	2	1	1	1	1	0	2	1	2	1	3	4	1	3	3	4	1	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:26032187G>T	uc003nfs.1	-	1	102	c.102C>A	c.(100-102)GGC>GGA	p.G34G		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	34					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						TTTTCACGCCGCCGGTAGCCG	0.627													16	138					4.7546e-09	5.85767e-09	1	0	T	26032187	T	T	26032187	2	4	227	1	0	0	0	0	0	0	0	1	7195	1074	38	3		3	HIST1H3B	6	26032187	Silent	SNP	G	TCGA-CV-7177-01A-11D-2012-08	10530588	26032187	145082880	37	41508											
SCAND3	114821	broad.mit.edu	37	chr6	28554410	28554410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcccaagtgtggtcttcttCtttaacctttactttgataa	9	18	5	9	0	3	1	0	1	3	0	4	1	4	1	2	1	2	0	2	1	4	8			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:28554410C>T	uc003nlo.2	-	1	703	c.85G>A	c.(85-87)GAA>AAA	p.E29K	uc003nlp.1_5'Flank	NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	29					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGGTCTTCTTCTTTAACCTTT	0.502													18	45					0	0	0	0	T	28554410	T	T	28554410	3	4	227	1	0	0	0	0	1	0	0	0	13941	922	32	2	3908	2	SCAND3	6	28554410	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	2522223	28554410	142560657	38	41509											
PAQR8	85315	broad.mit.edu	37	chr6	52268776	52268776	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	accctccagatcctcttcttCctggttagcgcttatttctt	5	17	5	14	1	3	1	0	0	3	1	6	1	6	1	4	1	1	2	4	1	2	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:52268776C>T	uc003pao.3	+	2	939	c.765C>T	c.(763-765)TTC>TTT	p.F255F		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	255	Helical; Name=5; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					TCCTCTTCTTCCTGGTTAGCG	0.577													23	52					0	0	0	0	T	52268776	T	T	52268776	2	4	227	1	0	0	0	0	0	0	0	1	11495	854	30	2		2	PAQR8	6	52268776	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	23714366	52268776	118846291	39	41510											
FAM184A	79632	broad.mit.edu	37	chr6	119341142	119341142	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggagtgtccattactttttaCcttctccagttctagaatct	8	17	6	10	0	3	1	0	0	3	1	5	2	4	2	3	1	2	1	3	1	4	7			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:119341142C>T	uc003pyj.2	-	4	1680	c.1332_splice	c.e4+1	p.K444_splice	FAM184A_uc003pyk.3_Splice_Site_p.K324_splice|FAM184A_uc003pyl.3_Splice_Site_p.K324_splice	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1											ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TTACTTTTTACCTTCTCCAGT	0.398													7	60					0	0	0	0	T	119341142	T	T	119341142	5	4	227	1	0	0	0	0	0	0	1	0	5539	521	18	4	2149	4	FAM184A	6	119341142	Splice_Site	SNP	C	TCGA-CV-7177-01A-11D-2012-08	67072366	119341142	51773925	40	41511											
TPD52L1	7164	broad.mit.edu	37	chr6	125541335	125541345	+	Splice_Site	DEL	TTCAGGTATGT	-	-																															agagttaaaagcagagttagTtcaggtatgtttagtaatct																								rs111553148		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:125541335_125541345delTTCAGGTATGT	uc003pzu.1	+	2	354	c.135_splice	c.e2+1	p.Q45_splice	TPD52L1_uc003pzv.1_Splice_Site_p.Q45_splice|TPD52L1_uc003pzw.1_Splice_Site_p.Q45_splice|TPD52L1_uc003pzx.1_Splice_Site_p.Q16_splice|TPD52L1_uc003pzy.1_Splice_Site_p.Q16_splice|TPD52L1_uc003pzz.1_Splice_Site_p.Q16_splice	NM_003287	NP_003278	Q16890	TPD53_HUMAN	tumor protein D52-like 1 isoform 1						DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		GCAGAGTTAGTTCAGGTATGTTTAGTAATCT	0.355													---	---	---								-	125541345	-	-	125541335	8	5	227	1	0	1	0	1	0	0	1	0	16465	1725	60	0	137	0	TPD52L1	6	125541335	Splice_Site	DEL	TTCAGGTATGT	TCGA-CV-7177-01A-11D-2012-08	6200193	125541335	45573732	41	41512											
LAMA2	3908	broad.mit.edu	37	chr6	129724979	129724979	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccaccagaatccttgatgagGctaaaaacatctccttcaat	14	10	5	12	0	2	3	1	2	1	1	4	3	3	3	4	1	1	1	4	1	5	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:129724979G>T	uc003qbn.2	+	40	5845	c.5740G>T	c.(5740-5742)GCT>TCT	p.A1914S	LAMA2_uc003qbo.2_Missense_Mutation_p.A1914S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1914	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CCTTGATGAGGCTAAAAACAT	0.398													12	26					2.31682e-05	2.70296e-05	1	0	T	129724979	T	T	129724979	3	4	227	1	0	0	0	0	1	0	0	0	8646	1203	42	4	5898	4	LAMA2	6	129724979	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	4183644	129724979	41390088	42	41513											
MAP3K4	4216	broad.mit.edu	37	chr6	161470492	161470492	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgcaggcactctgtttgtgGttaaacatcacaaaagactt	12	12	9	8	0	2	1	1	0	1	1	2	1	2	1	0	2	2	4	0	2	4	3	rs111941258		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:161470492G>C	uc003qtn.2	+	3	1330	c.1188G>C	c.(1186-1188)TGG>TGC	p.W396C	MAP3K4_uc010kkc.1_Missense_Mutation_p.W396C|MAP3K4_uc003qto.2_Missense_Mutation_p.W396C|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	396					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TCTGTTTGTGGTTAAACATCA	0.403													10	54					0	0	0	0	C	161470492	C	C	161470492	3	2	227	1	0	0	0	0	1	0	0	0	9305	1270	44	4	1198	4	MAP3K4	6	161470492	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	31745513	161470492	9644575	43	41514											
MIOS	54468	broad.mit.edu	37	chr7	7613368	7613368	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttagctggaaatgaagatcCacagctcaagtcactctggt	12	11	9	9	0	3	2	2	1	1	1	4	3	4	3	1	2	2	2	1	2	4	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:7613368C>T	uc003srf.2	+	4	1570	c.1262C>T	c.(1261-1263)CCA>CTA	p.P421L	MIOS_uc010ktp.1_Missense_Mutation_p.P421L	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	421	WD 6.										0						AATGAAGATCCACAGCTCAAG	0.408													19	81					0	0	0	0	T	7613368	T	T	7613368	3	4	227	1	0	0	0	0	1	0	0	0	9642	594	21	4	1264	4	MIOS	7	7613368	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08		7613368	151525295	44	41515											
ADCY1	107	broad.mit.edu	37	chr7	45725669	45725669	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgccctgcgagtctacaCaccatgccctgctctgctgc	5	9	8	19	1	2	0	0	0	2	0	2	1	2	0	4	0	7	2	4	0	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:45725669C>T	uc003tne.3	+	13	2200	c.2182C>T	c.(2182-2184)CAC>TAC	p.H728Y		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	728	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CGAGTCTACACACCATGCCCT	0.637													16	61					0	0	0	0	T	45725669	T	T	45725669	3	4	227	1	0	0	0	0	1	0	0	0	292	478	17	4	2232	4	ADCY1	7	45725669	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	38112301	45725669	113412994	45	41516											
DDC	1644	broad.mit.edu	37	chr7	50611693	50611693	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtacccgggctccacgtcagGgtagacctggcgtccctcaa	7	7	12	15	3	2	1	2	0	0	1	4	1	4	1	4	3	1	3	4	3	3	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:50611693G>T	uc003tpf.3	-	2	177	c.91C>A	c.(91-93)CCT>ACT	p.P31T	DDC_uc010kza.2_Missense_Mutation_p.P31T|DDC_uc003tpg.3_Missense_Mutation_p.P31T	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	31					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	TCCACGTCAGGGTAGACCTGG	0.567													28	253					1.61788e-16	2.0093e-16	1	0	T	50611693	T	T	50611693	3	4	227	1	0	0	0	0	1	0	0	0	4342	1232	43	4	1403	4	DDC	7	50611693	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	4886024	50611693	108526970	46	41517											
PDAP1	11333	broad.mit.edu	37	chr7	99002548	99002548	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagggcttgtatactgcctCgcccggcctttgtggcctcc	3	12	11	15	2	1	0	1	0	0	0	3	0	2	0	5	3	2	2	5	3	2	4	rs139029496		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:99002548C>A	uc003uqe.2	-	2	163	c.42G>T	c.(40-42)GCG>GCT	p.A14A		NM_014891	NP_055706	Q13442	HAP28_HUMAN	PDGFA associated protein 1	14					cell proliferation|signal transduction						0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)		Becaplermin(DB00102)	TATACTGCCTCGCCCGGCCTT	0.632													16	56					0.000422831	0.000468461	1	0	A	99002548	A	A	99002548	2	1	227	1	0	0	0	0	0	0	0	1	11667	871	31	3		3	PDAP1	7	99002548	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	48390855	99002548	60136115	47	41518											
OR2A2	442361	broad.mit.edu	37	chr7	143806750	143806750	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggtccagcactggcgattctCctctgtggactcttctctgt	4	14	10	13	1	4	0	0	0	4	0	7	2	5	1	2	3	1	1	2	3	0	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:143806750C>G	uc011ktz.1	+	1	75	c.75C>G	c.(73-75)CTC>CTG	p.L25L		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	25	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					TGGCGATTCTCCTCTGTGGAC	0.517													8	168					0	0	0	0	G	143806750	G	G	143806750	2	3	227	1	0	0	0	0	0	0	0	1	11031	842	30	2		2	OR2A2	7	143806750	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	44804202	143806750	15331913	48	41519											
BRF2	55290	broad.mit.edu	37	chr8	37702008	37702008	+	Nonstop_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctcccagtggatatccaTcagggagggttagggacact	9	9	14	9	0	1	0	1	0	0	0	3	3	3	3	2	4	1	2	2	4	2	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr8:37702008T>C	uc003xkk.2	-	4	1370	c.1260A>G	c.(1258-1260)TGA>TGG	p.*420W		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	420					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			TGGATATCCATCAGGGAGGGT	0.488													15	44					0	0	0	0	C	37702008	C	C	37702008	4	2	227	1	0	0	0	0	0	0	0	0	1516	1448	50	5	3	5	BRF2	8	37702008	Nonstop_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08		37702008	108662014	49	41520											
DEPDC6	64798	broad.mit.edu	37	chr8	120977486	120977486	+	Frame_Shift_Del	DEL	A	-	-																															tcccaggctgatgagccctgAaaacacactcctgcagccca																								rs35198895		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr8:120977486delA	uc003yow.3	+	4	627	c.440delA	c.(439-441)GAAfs	p.E147fs	DEPDC6_uc011lid.1_Frame_Shift_Del_p.E46fs	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	147	DEP 2.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATGAGCCCTGAAAACACACTC	0.468													---	---	---								-	120977486	-	-	120977486	7	5	227	1	0	1	0	1	0	0	0	0	4465	246	9	0	454	0	DEPDC6	8	120977486	Frame_Shift_Del	DEL	A	TCGA-CV-7177-01A-11D-2012-08	83275478	120977486	25386536	50	41521											
KHDRBS3	10656	broad.mit.edu	37	chr8	136554958	136554958	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgaagcgtttacaagaagAaaccttgacaaaaatgtcca	17	9	7	8	1	1	4	0	2	1	2	2	4	2	4	2	0	3	1	2	0	7	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr8:136554958A>T	uc003yuv.2	+	3	663	c.269A>T	c.(268-270)GAA>GTA	p.E90V	KHDRBS3_uc003yuw.2_Missense_Mutation_p.E90V	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	90	KH.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			TTACAAGAAGAAACCTTGACA	0.363													6	63					0	0	0	0	T	136554958	T	T	136554958	3	4	227	1	0	0	0	0	1	0	0	0	8187	246	9	5	279	5	KHDRBS3	8	136554958	Missense_Mutation	SNP	A	TCGA-CV-7177-01A-11D-2012-08	15577472	136554958	9809064	51	41522											
APBA1	320	broad.mit.edu	37	chr9	72082878	72082878	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agtcttcggggtcgcagggtCccggaactgtaacacataga	10	8	13	10	3	1	1	0	0	1	1	4	2	2	2	1	4	2	2	1	4	3	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:72082878C>T	uc004ahh.2	-	5	1619	c.1343G>A	c.(1342-1344)GGA>GAA	p.G448E		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	448	Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GTCGCAGGGTCCCGGAACTGT	0.557													65	154					0	0	0	0	T	72082878	T	T	72082878	3	4	227	1	0	0	0	0	1	0	0	0	756	855	30	2	1206	2	APBA1	9	72082878	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08		72082878	69130553	52	41523											
OR13C5	138799	broad.mit.edu	37	chr9	107361898	107361899	+	5'Flank	INS	-	GAAT	GAAT																															atgaatggagagagggaaggINSgaatgaatgaatgaatgaat																								rs139149858	by1000genomes	TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:107361898_107361899insGAAT	uc011lvp.1	-							NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						gagagggaagggaatgaatgaa	0.03													---	---	---								GAAT	107361899	GAAT	GAAT	107361898	6	5	227	0	1	1	1	0	0	0	0	0	10991	1247	43	0		0	OR13C5	9	107361898	5'Flank	INS	-	TCGA-CV-7177-01A-11D-2012-08	35279020	107361898	33851533	53	41524											
TNC	3371	broad.mit.edu	37	chr9	117808854	117808854	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgctttttggtatctctgaTtttgagaacaaaattgtcga	10	17	8	6	1	1	2	0	2	1	1	3	4	1	2	0	1	2	2	0	1	4	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:117808854T>G	uc004bjj.3	-	17	5322	c.4960A>C	c.(4960-4962)ATC>CTC	p.I1654L	TNC_uc010mvf.2_Intron	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1654	Fibronectin type-III 12.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GTATCTCTGATTTTGAGAACA	0.493													43	135					0	0	0	0	G	117808854	G	G	117808854	3	3	227	1	0	0	0	0	1	0	0	0	16336	1493	52	5	1693	5	TNC	9	117808854	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	10446956	117808854	23404577	54	41525											
PHF19	26147	broad.mit.edu	37	chr9	123632758	123632758	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagatgaggatctcattcagCggccctgatgtcttccctag	8	11	10	12	1	3	3	2	2	2	1	5	4	4	4	2	2	1	0	2	2	1	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:123632758C>T	uc004bks.1	-	4	580	c.327G>A	c.(325-327)CCG>CCA	p.P109P	PHF19_uc011lyf.1_5'Flank|PHF19_uc004bkr.2_5'Flank|PHF19_uc004bkt.2_Silent_p.P109P|PHF19_uc010mvk.2_Silent_p.P109P	NM_015651	NP_056466	Q5T6S3	PHF19_HUMAN	PHD finger protein 19 isoform a	109	PHD-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|breast(1)	2						TCTCATTCAGCGGCCCTGATG	0.627													24	183					0	0	0	0	T	123632758	T	T	123632758	2	4	227	1	0	0	0	0	0	0	0	1	11884	755	27	1		1	PHF19	9	123632758	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	5823904	123632758	17580673	55	41526											
LCN1	3933	broad.mit.edu	37	chr9	138415134	138415134	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggagaaaactgacgagccggGaaaatacacggccggtgagt	14	4	15	8	4	0	3	0	2	0	1	0	6	0	4	2	4	3	0	2	4	5	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:138415134G>A	uc004cfz.1	+	3	336	c.278G>A	c.(277-279)GGA>GAA	p.G93E	LCN1_uc004cga.1_Missense_Mutation_p.G93E	NM_002297	NP_002288	P31025	LCN1_HUMAN	lipocalin 1 precursor	93					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		GACGAGCCGGGAAAATACACG	0.632													5	45					0	0	0	0	A	138415134	A	A	138415134	3	1	227	1	0	0	0	0	1	0	0	0	8720	1174	41	2	288	2	LCN1	9	138415134	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	14782376	138415134	2798297	56	41527											
LRRTM3	347731	broad.mit.edu	37	chr10	68687181	68687181	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catttacggtctaactccctGagaaccatccctgtgcgaat	10	11	7	13	2	1	1	0	1	1	1	3	3	3	1	3	1	4	0	3	1	4	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr10:68687181G>A	uc001jmz.1	+	2	1057	c.507G>A	c.(505-507)CTG>CTA	p.L169L	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Silent_p.L169L	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	169	Extracellular (Potential).|LRR 5.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTAACTCCCTGAGAACCATCC	0.488													27	90					0	0	0	0	A	68687181	A	A	68687181	2	1	227	1	0	0	0	0	0	0	0	1	9091	1277	45	2		2	LRRTM3	10	68687181	Silent	SNP	G	TCGA-CV-7177-01A-11D-2012-08		68687181	66847566	57	41528											
PSAP	5660	broad.mit.edu	37	chr10	73590951	73590951	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatctccttgcatgaagcagAcatgttcggtttcggaagcc	9	12	10	10	2	1	2	0	1	1	1	4	3	1	3	2	2	3	4	2	2	3	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr10:73590951A>C	uc001jsm.2	-	4	411	c.307T>G	c.(307-309)TCT>GCT	p.S103A		NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	103	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						CATGAAGCAGACATGTTCGGT	0.483													30	62					0	0	0	0	C	73590951	C	C	73590951	3	2	227	1	0	0	0	0	1	0	0	0	12705	275	10	5	1327	5	PSAP	10	73590951	Missense_Mutation	SNP	A	TCGA-CV-7177-01A-11D-2012-08	4903770	73590951	61943796	58	41529											
COMTD1	118881	broad.mit.edu	37	chr10	76993922	76993922	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggatgcgttcgtttaggtttCgcacacactcggccgccacg	6	10	12	13	6	0	0	0	0	0	0	3	1	0	1	2	3	1	4	2	3	1	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr10:76993922C>T	uc001jxb.2	-	7	782	c.698G>A	c.(697-699)CGA>CAA	p.R233Q	COMTD1_uc001jxc.1_Silent_p.A324A	NM_144589	NP_653190	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing	233						integral to membrane	O-methyltransferase activity				0	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					GTTTAGGTTTCGCACACACTC	0.682													23	58					0	0	0	0	T	76993922	T	T	76993922	3	4	227	1	0	0	0	0	1	0	0	0	3741	884	31	1	94	1	COMTD1	10	76993922	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	3402971	76993922	58540825	59	41530											
LDB3	11155	broad.mit.edu	37	chr10	88451696	88451696	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtagacagcgcctctcccGtctaccaggctgtgattaag	8	9	10	14	3	2	2	0	1	2	1	3	2	2	2	4	1	2	2	4	1	3	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr10:88451696G>A	uc001kdv.2	+	5	756	c.733G>A	c.(733-735)GTC>ATC	p.V245I	LDB3_uc010qml.1_Missense_Mutation_p.V245I|LDB3_uc010qmm.1_Missense_Mutation_p.V313I|LDB3_uc001kdu.2_Missense_Mutation_p.V198I|LDB3_uc009xsz.2_Intron|LDB3_uc001kdr.2_Missense_Mutation_p.V198I|LDB3_uc009xsy.2_Missense_Mutation_p.V313I|LDB3_uc001kds.2_Missense_Mutation_p.V245I|LDB3_uc001kdt.2_RNA	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1	245						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						CGCCTCTCCCGTCTACCAGGC	0.602													6	107					0	0	0	0	A	88451696	A	A	88451696	3	1	227	1	0	0	0	0	1	0	0	0	8737	1145	40	1	986	1	LDB3	10	88451696	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	11457774	88451696	47083051	60	41531											
MUC6	4588	broad.mit.edu	37	chr11	1026050	1026050	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaatacgaagcgctggccgtCgaaggtgatgacgtggccct	9	7	15	10	5	0	2	0	2	0	0	1	5	0	2	2	3	2	1	2	3	4	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:1026050C>G	uc001lsw.2	-	21	2689	c.2638G>C	c.(2638-2640)GAC>CAC	p.D880H		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	880	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGCTGGCCGTCGAAGGTGATG	0.677													3	7					0	0	0	0	G	1026050	G	G	1026050	3	3	227	1	0	0	0	0	1	0	0	0	10033	884	31	3	4733	3	MUC6	11	1026050	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08		1026050	133980466	61	41532											
TRIM21	6737	broad.mit.edu	37	chr11	4406682	4406684	+	In_Frame_Del	DEL	AGA	-	-																															gccatggtcagtgatgttgtAgaaggagaccatgccagcct																										TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:4406682_4406684delAGA	uc001lyy.1	-	7	1372_1374	c.1259_1261delTCT	c.(1258-1263)TTCTAC>TAC	p.F420del		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	420	B30.2/SPRY.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		GTGATGTTGTAGAAGGAGACCAT	0.532													---	---	---								-	4406684	-	-	4406682	7	5	227	1	0	1	0	1	0	0	0	0	16562	420	15	0	170	0	TRIM21	11	4406682	In_Frame_Del	DEL	AGA	TCGA-CV-7177-01A-11D-2012-08	3380632	4406682	130599834	62	41533											
INSC	387755	broad.mit.edu	37	chr11	15222416	15222416	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttgccggcaggacagttTccggtgcttgtacccccagg	5	10	14	12	2	0	0	0	0	0	0	1	1	1	1	4	5	3	5	4	5	1	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:15222416T>G	uc001mly.2	+	7	927	c.881T>G	c.(880-882)TTC>TGC	p.F294C	INSC_uc001mlz.2_Missense_Mutation_p.F247C|INSC_uc001mma.2_Missense_Mutation_p.F247C|INSC_uc010rcs.1_Missense_Mutation_p.F282C|INSC_uc001mmb.2_Missense_Mutation_p.F247C|INSC_uc001mmc.2_Intron	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	294					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CAGGACAGTTTCCGGTGCTTG	0.587													3	45					0	0	0	0	G	15222416	G	G	15222416	3	3	227	1	0	0	0	0	1	0	0	0	7803	1783	62	5	907	5	INSC	11	15222416	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	10815734	15222416	119784100	63	41534											
KCNA4	3739	broad.mit.edu	37	chr11	30033979	30033979	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccgctgtcgcctcctcctccGactaccccggctgctctgag	3	9	9	20	4	1	1	0	1	1	0	5	2	4	1	7	1	2	3	7	1	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:30033979G>C	uc001msk.2	-	2	1399	c.247C>G	c.(247-249)CGG>GGG	p.R83G		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	83						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTCCTCCTCCGACTACCCCGG	0.632													4	81					0	0	0	0	C	30033979	C	C	30033979	3	2	227	1	0	0	0	0	1	0	0	0	8044	1057	37	3	1718	3	KCNA4	11	30033979	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	14811563	30033979	104972537	64	41535											
LRRC4C	57689	broad.mit.edu	37	chr11	40137416	40137416	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttagacaagtatacaaaagCtccattcgggatggtagtaa	15	11	9	6	1	0	1	0	0	0	1	2	2	1	2	1	2	2	4	1	2	8	7			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:40137416C>T	uc001mxa.1	-	2	2391	c.427G>A	c.(427-429)GCT>ACT	p.A143T	LRRC4C_uc001mxc.1_Missense_Mutation_p.A139T|LRRC4C_uc001mxd.1_Missense_Mutation_p.A139T|LRRC4C_uc001mxb.1_Missense_Mutation_p.A139T	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	143	LRR 3.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TATACAAAAGCTCCATTCGGG	0.438													23	53					0	0	0	0	T	40137416	T	T	40137416	3	4	227	1	0	0	0	0	1	0	0	0	9058	797	28	4	1499	4	LRRC4C	11	40137416	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	10103437	40137416	94869100	65	41536											
OR5M11	219487	broad.mit.edu	37	chr11	56310877	56310878	+	5'Flank	INS	-	TT	TT																															ttctgggtactaccataaacINStggttttggtaattatggta																								rs137998724	by1000genomes	TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:56310877_56310878insTT	uc010rjl.1	-							NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTACCATAAACTGGTTTTGGTA	0.287													---	---	---								TT	56310878	TT	TT	56310877	6	5	227	0	1	1	1	0	0	0	0	0	11228	580	20	0		0	OR5M11	11	56310877	5'Flank	INS	-	TCGA-CV-7177-01A-11D-2012-08	16173461	56310877	78695639	66	41537											
VPS37C	55048	broad.mit.edu	37	chr11	60899313	60899313	+	Frame_Shift_Del	DEL	C	-	-																															taatacccaggccaggcaggCcccggcggtggtgggaaccc																										TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:60899313delC	uc001nqv.1	-	5	1107	c.1047delG	c.(1045-1047)GGGfs	p.G349fs		NM_017966	NP_060436	A5D8V6	VP37C_HUMAN	vacuolar protein sorting 37C	349	Pro-rich.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0						GCCAGGCAGGCCCCGGCGGTG	0.697													---	---	---								-	60899313	-	-	60899313	7	5	227	1	0	1	0	1	0	0	0	0	17275	726	26	0	24	0	VPS37C	11	60899313	Frame_Shift_Del	DEL	C	TCGA-CV-7177-01A-11D-2012-08	4588436	60899313	74107203	67	41538											
SLC22A12	116085	broad.mit.edu	37	chr11	64359366	64359366	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctggagcgaggccgacaCggagccgtgtgtggatggct	7	6	18	10	4	0	0	0	0	0	0	0	5	0	3	2	5	3	2	2	5	0	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:64359366C>T	uc001oam.1	+	1	1085	c.338C>T	c.(337-339)ACG>ATG	p.T113M	SLC22A12_uc009ypr.1_Missense_Mutation_p.T113M|SLC22A12_uc001oal.1_Translation_Start_Site|SLC22A12_uc009yps.1_Missense_Mutation_p.T113M|SLC22A12_uc001oan.1_Missense_Mutation_p.T113M|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	113					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						GAGGCCGACACGGAGCCGTGT	0.672													18	27					0	0	0	0	T	64359366	T	T	64359366	3	4	227	1	0	0	0	0	1	0	0	0	14508	536	19	1	340	1	SLC22A12	11	64359366	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	3460053	64359366	70647150	68	41539											
ZNF202	7753	broad.mit.edu	37	chr11	123597653	123597653	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtgtatatcctccaaactCagatcttcctgctccagaca	10	12	5	14	0	2	2	1	0	1	2	6	2	6	2	4	0	2	2	4	0	3	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:123597653C>G	uc001pzd.1	-	9	1399	c.999G>C	c.(997-999)CTG>CTC	p.L333L	ZNF202_uc001pzc.1_Silent_p.L109L|ZNF202_uc001pze.1_Silent_p.L333L|ZNF202_uc001pzf.1_Silent_p.L333L	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	333					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CCTCCAAACTCAGATCTTCCT	0.463													9	226					0	0	0	0	G	123597653	G	G	123597653	2	3	227	1	0	0	0	0	0	0	0	1	17830	813	29	2		2	ZNF202	11	123597653	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	59238287	123597653	11408863	69	41540											
SLCO1C1	53919	broad.mit.edu	37	chr12	20885884	20885884	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcccttggaatattctctGgggggatagttatgaaaaaa	12	12	12	5	0	1	1	0	1	1	0	2	3	1	3	1	5	0	1	1	5	7	5			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:20885884G>T	uc001rej.3	+	11	1583	c.1228G>T	c.(1228-1230)GGG>TGG	p.G410W	SLCO1C1_uc010sii.1_Missense_Mutation_p.G410W|SLCO1C1_uc010sij.1_Missense_Mutation_p.G361W|SLCO1C1_uc009zip.2_Missense_Mutation_p.G244W|SLCO1C1_uc001rei.2_Missense_Mutation_p.G410W|SLCO1C1_uc010sik.1_Missense_Mutation_p.G292W	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	410	Helical; Name=8; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					AATATTCTCTGGGGGGATAGT	0.383													16	74					3.52763e-06	4.24418e-06	1	0	T	20885884	T	T	20885884	3	4	227	1	0	0	0	0	1	0	0	0	14789	1348	47	4	1262	4	SLCO1C1	12	20885884	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08		20885884	112966011	70	41541											
PPFIBP1	8496	broad.mit.edu	37	chr12	27824450	27824450	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgaaaaatcaaagttgacTcctaagccagagacttcatt	15	11	6	9	0	3	3	2	2	1	1	4	4	4	3	2	0	1	1	2	0	4	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:27824450T>G	uc001ric.1	+	14	1661	c.1284T>G	c.(1282-1284)ACT>ACG	p.T428T	PPFIBP1_uc010sjr.1_Silent_p.T259T|PPFIBP1_uc001rib.1_Silent_p.T411T|PPFIBP1_uc001ria.2_Silent_p.T397T|PPFIBP1_uc001rid.1_Silent_p.T275T	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	428					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					CAAAGTTGACTCCTAAGCCAG	0.343													7	71					0	0	0	0	G	27824450	G	G	27824450	2	3	227	1	0	0	0	0	0	0	0	1	12368	1538	54	5		5	PPFIBP1	12	27824450	Silent	SNP	T	TCGA-CV-7177-01A-11D-2012-08	6938566	27824450	106027445	71	41542											
KRT73	319101	broad.mit.edu	37	chr12	53007615	53007616	+	Frame_Shift_Del	DEL	GG	-	-																															gatggacgtgtcgctgatgtGggactggatctgagcagtct																										TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:53007615_53007616delGG	uc001sas.2	-	5	875_876	c.840_841delCC	c.(838-843)TCCCACfs	p.S280fs		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	280_281	Rod.|Linker 12.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCGCTGATGTGGGACTGGATCT	0.559													---	---	---								-	53007616	-	-	53007615	7	5	227	1	0	1	0	1	0	0	0	0	8525	1348	47	0	801	0	KRT73	12	53007615	Frame_Shift_Del	DEL	GG	TCGA-CV-7177-01A-11D-2012-08	25183165	53007615	80844280	72	41543											
STAC3	246329	broad.mit.edu	37	chr12	57640658	57640659	+	Frame_Shift_Del	DEL	AC	-	-																															cccagtgcgcagggtttcaaAcacaggatcattgcgattgg																										TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:57640658_57640659delAC	uc001snp.2	-	6	726_727	c.531_532delGT	c.(529-534)GTGTTTfs	p.V177fs	STAC3_uc009zpl.2_5'UTR|STAC3_uc001snq.2_Frame_Shift_Del_p.V138fs|STAC3_uc010srm.1_5'UTR	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	177_178					intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						AGGGTTTCAAACACAGGATCAT	0.51													---	---	---								-	57640659	-	-	57640658	7	5	227	1	0	1	0	1	0	0	0	0	15307	43	2	0	590	0	STAC3	12	57640658	Frame_Shift_Del	DEL	AC	TCGA-CV-7177-01A-11D-2012-08	4633043	57640658	76211237	73	41544											
KIF5A	3798	broad.mit.edu	37	chr12	57975223	57975223	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccgtccggcctggccactaCccagcatcctcacccaccaa	8	5	6	22	2	1	0	1	0	0	0	3	0	3	0	8	2	2	1	8	2	2	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:57975223C>T	uc001sor.1	+	25	2989	c.2781C>T	c.(2779-2781)TAC>TAT	p.Y927Y	KIF5A_uc010srr.1_Silent_p.Y838Y	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	927	Globular.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						CTGGCCACTACCCAGCATCCT	0.547													9	72					0	0	0	0	T	57975223	T	T	57975223	2	4	227	1	0	0	0	0	0	0	0	1	8344	518	18	4		4	KIF5A	12	57975223	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	334565	57975223	75876672	74	41545											
BEST3	144453	broad.mit.edu	37	chr12	70048856	70048856	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caattaaaagagctggctgaGagctcatggggtctggactt	11	10	13	7	0	2	2	1	1	1	2	2	4	2	3	0	4	2	3	0	4	3	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:70048856G>C	uc001svg.2	-	10	2065	c.1838C>G	c.(1837-1839)TCT>TGT	p.S613C	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.S400C|BEST3_uc010stm.1_Missense_Mutation_p.S507C	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	613	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			AGCTGGCTGAGAGCTCATGGG	0.488													18	32					0	0	0	0	C	70048856	C	C	70048856	3	2	227	1	0	0	0	0	1	0	0	0	1408	942	33	2	172	2	BEST3	12	70048856	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	12073633	70048856	63803039	75	41546											
BTBD11	121551	broad.mit.edu	37	chr12	108006645	108006645	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagctgacctgaatgtggAggtgagggtgcagaggccag	9	6	19	7	1	0	4	0	3	0	1	0	6	0	6	2	5	2	2	2	5	1	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:108006645A>G	uc001tmk.1	+	6	2419	c.1898A>G	c.(1897-1899)GAG>GGG	p.E633G	BTBD11_uc009zut.1_Missense_Mutation_p.E633G|BTBD11_uc001tmj.2_Missense_Mutation_p.E633G|BTBD11_uc001tml.1_Missense_Mutation_p.E170G	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	633						integral to membrane	DNA binding			skin(2)|ovary(1)	3						CTGAATGTGGAGGTGAGGGTG	0.632													6	5					0	0	0	0	G	108006645	G	G	108006645	3	3	227	1	0	0	0	0	1	0	0	0	1544	318	11	5	2025	5	BTBD11	12	108006645	Missense_Mutation	SNP	A	TCGA-CV-7177-01A-11D-2012-08	37957789	108006645	25845250	76	41547											
JUB	84962	broad.mit.edu	37	chr14	23450563	23450563	+	Frame_Shift_Del	DEL	C	-	-																															ctcctccagacccgacggctCaatccccgagggttctccgc																										TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr14:23450563delC	uc001whz.2	-	1	1289	c.913delG	c.(913-915)GAGfs	p.E305fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	305	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CCCGACGGCTCAATCCCCGAG	0.697													---	---	---								-	23450563	-	-	23450563	7	5	227	1	0	1	0	1	0	0	0	0	8007	835	29	0	735	0	JUB	14	23450563	Frame_Shift_Del	DEL	C	TCGA-CV-7177-01A-11D-2012-08		23450563	83898977	77	41548											
JPH4	84502	broad.mit.edu	37	chr14	24040391	24040391	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcccttgcatcccagcctCatcctcagcctcatagccag	7	9	7	18	0	3	0	3	0	0	0	5	0	5	0	6	1	4	1	6	1	1	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr14:24040391C>G	uc001wkq.2	-	6	2467	c.1549G>C	c.(1549-1551)GAG>CAG	p.E517Q	JPH4_uc010tnr.1_Missense_Mutation_p.E182Q|JPH4_uc001wkr.2_Missense_Mutation_p.E517Q	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	517	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		ATCCCAGCCTCATCCTCAGCC	0.647													18	164					0	0	0	0	G	24040391	G	G	24040391	3	3	227	1	0	0	0	0	1	0	0	0	8002	835	29	2	345	2	JPH4	14	24040391	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	589828	24040391	83309149	78	41549											
SERPINA9	327657	broad.mit.edu	37	chr14	94931144	94931144	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcgggaggatggtttccagaTtgtaggaggcagaaatggaa	12	9	16	4	1	0	2	0	0	0	2	2	6	1	6	1	6	0	3	1	6	3	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr14:94931144T>C	uc001ydf.2	-	4	1165	c.1004A>G	c.(1003-1005)AAT>AGT	p.N335S	SERPINA9_uc001yde.2_Missense_Mutation_p.N235S|SERPINA9_uc010avc.2_Missense_Mutation_p.N186S|SERPINA9_uc001ydg.2_Missense_Mutation_p.N299S|SERPINA9_uc001ydh.1_Missense_Mutation_p.N335S|SERPINA9_uc001ydi.1_Missense_Mutation_p.N299S	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	317					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GGTTTCCAGATTGTAGGAGGC	0.448													24	45					0	0	0	0	C	94931144	C	C	94931144	3	2	227	1	0	0	0	0	1	0	0	0	14160	1493	52	5	311	5	SERPINA9	14	94931144	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	70890753	94931144	12418396	79	41550											
AHNAK2	113146	broad.mit.edu	37	chr14	105408273	105408273	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cggaggtcagtggtcttgagGtccccctgcatggagggaat	7	9	16	9	1	2	1	1	1	1	0	3	4	3	4	2	6	1	1	2	6	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr14:105408273G>T	uc010axc.1	-	7	13635	c.13515C>A	c.(13513-13515)GAC>GAA	p.D4505E	AHNAK2_uc001ypx.2_Missense_Mutation_p.D4405E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4505						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGGTCTTGAGGTCCCCCTGCA	0.612													7	264					8.12818e-05	9.20397e-05	1	0	T	105408273	T	T	105408273	3	4	227	1	0	0	0	0	1	0	0	0	415	1252	44	4	3876	4	AHNAK2	14	105408273	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	10477129	105408273	1941267	80	41551											
JAG2	3714	broad.mit.edu	37	chr14	105609208	105609208	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcaccgcggcccagatcctCgtcctcctcatcctccctga	5	9	6	21	3	2	2	2	1	0	1	8	2	7	2	7	1	0	0	7	1	0	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr14:105609208C>T	uc001yqg.2	-	26	3945	c.3541G>A	c.(3541-3543)GAG>AAG	p.E1181K	JAG2_uc010axf.2_Silent_p.T4T|JAG2_uc001yqf.2_Missense_Mutation_p.E585K|JAG2_uc001yqh.2_Missense_Mutation_p.E1143K	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	1181	Cytoplasmic (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CCCAGATCCTCGTCCTCCTCA	0.443													19	13					0	0	0	0	T	105609208	T	T	105609208	3	4	227	1	0	0	0	0	1	0	0	0	7974	893	31	1	179	1	JAG2	14	105609208	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	200935	105609208	1740332	81	41552											
TJP1	7082	broad.mit.edu	37	chr15	30011211	30011211	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgctggcttgtttctctacGtatgggagttggggttcata	5	16	13	7	1	2	0	1	0	1	0	3	1	2	1	0	4	2	6	0	4	3	7			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr15:30011211G>A	uc001zcr.2	-	21	3610	c.3135C>T	c.(3133-3135)TAC>TAT	p.Y1045Y	TJP1_uc010azl.2_Silent_p.Y1033Y|TJP1_uc001zcq.2_Silent_p.Y969Y|TJP1_uc001zcs.2_Silent_p.Y965Y	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1045					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GTTTCTCTACGTATGGGAGTT	0.502													73	172					0	0	0	0	A	30011211	A	A	30011211	2	1	227	1	0	0	0	0	0	0	0	1	15995	1140	40	1		1	TJP1	15	30011211	Silent	SNP	G	TCGA-CV-7177-01A-11D-2012-08		30011211	72520181	82	41553											
TRPM1	4308	broad.mit.edu	37	chr15	31294599	31294599	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttggtttcttccaggggaTaggaaatagtgccttctata	9	16	10	6	0	2	0	0	0	2	0	3	2	3	2	2	4	1	1	2	4	5	9			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr15:31294599T>C	uc001zfm.2	-	27	4366	c.4238A>G	c.(4237-4239)TAT>TGT	p.Y1413C	TRPM1_uc010azy.2_Missense_Mutation_p.Y1320C|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1413	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTCCAGGGGATAGGAAATAGT	0.393													37	74					0	0	0	0	C	31294599	C	C	31294599	3	2	227	1	0	0	0	0	1	0	0	0	16652	1406	49	5	577	5	TRPM1	15	31294599	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	1283388	31294599	71236793	83	41554											
ZSCAN2	54993	broad.mit.edu	37	chr15	85164140	85164140	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccggaaatcccacctcatCacacacgagaggacccacac	14	3	7	17	2	2	1	2	0	0	1	3	4	3	3	4	2	1	0	4	2	1	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr15:85164140C>T	uc002bkr.2	+	3	940	c.714C>T	c.(712-714)ATC>ATT	p.I238I	ZSCAN2_uc010bmz.1_Silent_p.I236I|ZSCAN2_uc010bna.2_Silent_p.I88I|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	238	C2H2-type 1.				cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		CCCACCTCATCACACACGAGA	0.493													10	74					0	0	0	0	T	85164140	T	T	85164140	2	4	227	1	0	0	0	0	0	0	0	1	18298	816	29	2		2	ZSCAN2	15	85164140	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	53869541	85164140	17367252	84	41555											
VPS33B	26276	broad.mit.edu	37	chr15	91544674	91544674	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcttggccagagaactgAaggcatcagtaatctttcct	10	12	8	11	0	3	2	1	1	2	1	5	3	5	2	3	2	1	2	3	2	3	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr15:91544674A>C	uc002bqp.1	-	19	1778	c.1424T>G	c.(1423-1425)TTC>TGC	p.F475C	VPS33B_uc002bqq.1_Missense_Mutation_p.F384C|VPS33B_uc010uqu.1_Missense_Mutation_p.F448C	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	475					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					CAGAGAACTGAAGGCATCAGT	0.463													7	65					0	0	0	0	C	91544674	C	C	91544674	3	2	227	1	0	0	0	0	1	0	0	0	17270	246	9	5	449	5	VPS33B	15	91544674	Missense_Mutation	SNP	A	TCGA-CV-7177-01A-11D-2012-08	6380534	91544674	10986718	85	41556											
NSMCE1	197370	broad.mit.edu	37	chr16	27237111	27237111	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggttcagcattcgactggaaGtacttggccacgcagggtaa	10	9	13	9	2	1	0	1	0	0	0	2	2	1	1	1	4	2	5	1	4	3	5			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:27237111G>A	uc002doi.1	-	7	755	c.657C>T	c.(655-657)TAC>TAT	p.Y219Y	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	219	NSE1-type.				DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0						TCGACTGGAAGTACTTGGCCA	0.612													20	48					0	0	0	0	A	27237111	A	A	27237111	2	1	227	1	0	0	0	0	0	0	0	1	10729	1024	36	4		4	NSMCE1	16	27237111	Silent	SNP	G	TCGA-CV-7177-01A-11D-2012-08		27237111	63117642	86	41557											
MMP2	4313	broad.mit.edu	37	chr16	55539340	55539340	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaagcatcaaatccgacTggctaggctgctgagctggc	9	9	13	10	1	1	1	1	1	0	0	2	3	2	2	1	4	3	5	1	4	3	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:55539340T>C	uc002ehz.3	+	13	2280	c.1969T>C	c.(1969-1971)TGG>CGG	p.W657R	MMP2_uc010vhd.1_Missense_Mutation_p.W581R|MMP2_uc010ccc.2_Missense_Mutation_p.W607R|MMP2_uc002eia.3_Missense_Mutation_p.W154R	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	657	Required for inhibitor TIMP2 binding.|Hemopexin-like 4.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CAAATCCGACTGGCTAGGCTG	0.567													8	175					0	0	0	0	C	55539340	C	C	55539340	3	2	227	1	0	0	0	0	1	0	0	0	9711	1580	55	5	2026	5	MMP2	16	55539340	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	28302229	55539340	34815413	87	41558											
NOB1	28987	broad.mit.edu	37	chr16	69782153	69782153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttgaaacagccatggcagCgcaagatgtagctccgggcc	11	6	12	12	2	0	2	0	1	0	1	1	2	1	2	3	2	4	4	3	2	3	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:69782153C>T	uc002exs.2	-	7	822	c.806G>A	c.(805-807)CGC>CAC	p.R269H		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	269						nucleus	metal ion binding|protein binding				0						GCCATGGCAGCGCAAGATGTA	0.473													5	41					0	0	0	0	T	69782153	T	T	69782153	3	4	227	1	0	0	0	0	1	0	0	0	10565	768	27	1	444	1	NOB1	16	69782153	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	14242813	69782153	20572600	88	41559											
CNTNAP4	85445	broad.mit.edu	37	chr16	76572217	76572217	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttttacaaagaatacctttCtgtgatcattgccaaaaatg	14	14	5	8	0	2	2	1	1	1	1	2	2	2	2	2	0	3	0	2	0	6	5	rs35153994		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:76572217C>G	uc002feu.1	+	21	3585	c.3200C>G	c.(3199-3201)TCT>TGT	p.S1067C	CNTNAP4_uc002fev.1_Missense_Mutation_p.S931C|CNTNAP4_uc010chb.1_Missense_Mutation_p.S994C|CNTNAP4_uc002fex.1_Missense_Mutation_p.S1070C	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1067	Extracellular (Potential).|Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GAATACCTTTCTGTGATCATT	0.358													17	125					0	0	0	0	G	76572217	G	G	76572217	3	3	227	1	0	0	0	0	1	0	0	0	3664	913	32	2	3287	2	CNTNAP4	16	76572217	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	6790064	76572217	13782536	89	41560											
JPH3	57338	broad.mit.edu	37	chr16	87724057	87724057	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcgttgggacttgaccttCtccccgccccagaaatcctt	6	11	8	16	2	1	2	0	1	1	1	3	3	2	3	6	1	1	1	6	1	1	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:87724057C>T	uc002fkd.2	+	4	2345	c.2091C>T	c.(2089-2091)TTC>TTT	p.F697F	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	697	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		ACTTGACCTTCTCCCCGCCCC	0.672													8	6					0	0	0	0	T	87724057	T	T	87724057	2	4	227	1	0	0	0	0	0	0	0	1	8001	912	32	2		2	JPH3	16	87724057	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	11151840	87724057	2630696	90	41561											
TP53	7157	broad.mit.edu	37	chr17	7578478	7578478	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggacgcgggtgccgggcgggGgtgtggaatcaacccacagc	7	4	19	11	4	1	0	1	0	0	0	1	2	1	2	2	6	3	0	2	6	2	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:7578478G>T	uc002gim.2	-	5	646	c.452C>A	c.(451-453)CCC>CAC	p.P151H	TP53_uc002gig.1_Missense_Mutation_p.P151H|TP53_uc002gih.2_Missense_Mutation_p.P151H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P19H|TP53_uc010cng.1_Missense_Mutation_p.P19H|TP53_uc002gii.1_Missense_Mutation_p.P19H|TP53_uc010cnh.1_Missense_Mutation_p.P151H|TP53_uc010cni.1_Missense_Mutation_p.P151H|TP53_uc002gij.2_Missense_Mutation_p.P151H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P58H|TP53_uc002gio.2_Missense_Mutation_p.P19H|TP53_uc010vug.1_Missense_Mutation_p.P112H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	151	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.P151H(25)|p.P151T(13)|p.P151P(12)|p.P151A(8)|p.0?(7)|p.P151fs*30(7)|p.P151L(6)|p.P151R(6)|p.T150fs*16(3)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P153fs*28(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P152fs*14(1)|p.T150_P151delTP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGGGCGGGGGTGTGGAATC	0.607		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			39	24					4.07013e-28	5.13771e-28	1	0	T	7578478	T	T	7578478	3	4	227	1	0	0	0	0	1	0	0	0	16448	1232	43	4	846	4	TP53	17	7578478	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08		7578478	73616732	91	41562											
MYH8	4626	broad.mit.edu	37	chr17	10298660	10298660	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttcagctggtcaatttcCtcatccttttctgcgatttt	5	19	5	12	1	5	0	3	0	2	0	7	1	7	0	2	1	2	1	2	1	1	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:10298660C>G	uc002gmm.2	-	34	4847	c.4752G>C	c.(4750-4752)GAG>GAC	p.E1584D	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1584	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GGTCAATTTCCTCATCCTTTT	0.433									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				10	58					0	0	0	0	G	10298660	G	G	10298660	3	3	227	1	0	0	0	0	1	0	0	0	10094	680	24	4	1089	4	MYH8	17	10298660	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	2720182	10298660	70896550	92	41563											
CCL23	6368	broad.mit.edu	37	chr17	34340342	34340342	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacgtcgccccttcttggtGaggaagctagggaacaaggg	11	7	14	9	2	1	1	0	1	1	0	2	3	1	3	2	4	3	1	2	4	5	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:34340342G>T	uc002hkt.1	-	4	329	c.258C>A	c.(256-258)CTC>CTA	p.L86L	CCL23_uc002hks.1_Silent_p.L103L	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	86					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	CCTTCTTGGTGAGGAAGCTAG	0.542													9	15					7.48243e-07	9.07318e-07	1	0	T	34340342	T	T	34340342	2	4	227	1	0	0	0	0	0	0	0	1	2908	1277	45	2		2	CCL23	17	34340342	Silent	SNP	G	TCGA-CV-7177-01A-11D-2012-08	24041682	34340342	46854868	93	41564											
TTC25	83538	broad.mit.edu	37	chr17	40093075	40093075	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttacaccccaccaagggaGagcccaagtggaaggcctcg	11	5	11	14	1	1	1	0	0	1	1	2	3	1	2	5	3	2	0	5	3	4	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:40093075G>A	uc002hyj.3	+	5	609	c.520G>A	c.(520-522)GAG>AAG	p.E174K	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Missense_Mutation_p.E174K	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	174						cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				CACCAAGGGAGAGCCCAAGTG	0.522													26	68					0	0	0	0	A	40093075	A	A	40093075	3	1	227	1	0	0	0	0	1	0	0	0	16761	943	33	2	538	2	TTC25	17	40093075	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	5752733	40093075	41102135	94	41565											
TBX21	30009	broad.mit.edu	37	chr17	45820480	45820480	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gactcccccaacacaggagcGcactggatgcgccaggaagt	11	4	12	14	2	0	0	0	0	0	0	1	4	1	3	3	3	3	1	3	3	2	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:45820480G>A	uc002ilv.1	+	3	901	c.690G>A	c.(688-690)GCG>GCA	p.A230A		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	230	T-box.				lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						ACACAGGAGCGCACTGGATGC	0.552													34	56					0	0	0	0	A	45820480	A	A	45820480	2	1	227	1	0	0	0	0	0	0	0	1	15723	1074	38	1		1	TBX21	17	45820480	Silent	SNP	G	TCGA-CV-7177-01A-11D-2012-08	5727405	45820480	35374730	95	41566											
TUBD1	51174	broad.mit.edu	37	chr17	57958324	57958324	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtactgatcttctaaattCtgtgtaacgaaagctcctaa	13	13	7	8	1	3	1	0	1	3	0	4	3	4	1	1	0	3	3	1	0	6	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:57958324C>T	uc002ixw.1	-	4	746	c.468G>A	c.(466-468)CAG>CAA	p.Q156Q	TUBD1_uc010ddf.1_Silent_p.Q156Q|TUBD1_uc010ddg.1_Silent_p.Q121Q|TUBD1_uc010ddh.1_Silent_p.Q37Q|TUBD1_uc010wok.1_Silent_p.Q156Q|TUBD1_uc002ixx.1_Silent_p.Q156Q|TUBD1_uc010wol.1_Intron|TUBD1_uc010ddi.1_Intron	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	156					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			CTTCTAAATTCTGTGTAACGA	0.383													21	93					0	0	0	0	T	57958324	T	T	57958324	2	4	227	1	0	0	0	0	0	0	0	1	16830	912	32	2		2	TUBD1	17	57958324	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	12137844	57958324	23236886	96	41567											
CASKIN2	57513	broad.mit.edu	37	chr17	73498721	73498721	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcccttcggcctccccctCagcatccccctctgtggggc	2	9	10	20	1	2	0	1	0	1	0	5	0	4	0	6	4	1	1	6	4	0	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:73498721C>T	uc002joc.2	-	18	2984	c.2434G>A	c.(2434-2436)GAG>AAG	p.E812K	CASKIN2_uc010wsc.1_Missense_Mutation_p.E730K	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	812	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCTCCCCCTCAGCATCCCCC	0.692													10	3					0	0	0	0	T	73498721	T	T	73498721	3	4	227	1	0	0	0	0	1	0	0	0	2679	835	29	2	1186	2	CASKIN2	17	73498721	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	15540397	73498721	7696489	97	41568											
TMC8	147138	broad.mit.edu	37	chr17	76134756	76134756	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcccgcccattggccagcGtgccctccactacctgggct	4	8	10	19	2	0	0	0	0	0	0	2	0	2	0	6	2	3	2	6	2	1	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:76134756G>C	uc002jup.2	+	14	2148	c.1766G>C	c.(1765-1767)CGT>CCT	p.R589P	TMC8_uc002juq.2_Missense_Mutation_p.R366P|TMC8_uc002jur.1_Missense_Mutation_p.V39L	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	589	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			ATTGGCCAGCGTGCCCTCCAC	0.667									Epidermodysplasia_Verruciformis_Familial_Clustering_of				7	65					0	0	0	0	C	76134756	C	C	76134756	3	2	227	1	0	0	0	0	1	0	0	0	16057	1145	40	3	1816	3	TMC8	17	76134756	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	2636035	76134756	5060454	98	41569											
CBX2	84733	broad.mit.edu	37	chr17	77753183	77753183	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ataacagctgggagccggagGagaacatcctggacccgagg	12	4	15	10	2	0	1	0	0	0	1	1	6	1	4	3	5	4	1	3	5	2	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:77753183G>T	uc002jxc.2	+	3	181	c.139G>T	c.(139-141)GAG>TAG	p.E47*	CBX2_uc002jxb.1_Nonsense_Mutation_p.E47*	NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	47	Chromo.				cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGAGCCGGAGGAGAACATCCT	0.632													19	12					8.00594e-06	9.55748e-06	1	0	T	77753183	T	T	77753183	4	4	227	1	0	0	0	0	0	1	0	0	2730	1175	41	2	149	2	CBX2	17	77753183	Nonsense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	1618427	77753183	3442027	99	41570											
RNF213	57674	broad.mit.edu	37	chr17	78348328	78348328	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgaatacaaggctctccGtgatgctgtggccaaagctg	10	9	12	10	2	1	2	0	2	1	0	2	3	1	2	2	2	3	3	2	2	4	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:78348328G>A	uc002jyh.1	+	25	7455	c.7232G>A	c.(7231-7233)CGT>CAT	p.R2411H	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.R793H	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AAGGCTCTCCGTGATGCTGTG	0.577													41	28					0	0	0	0	A	78348328	A	A	78348328	3	1	227	1	0	0	0	0	1	0	0	0	13542	1145	40	1	13526	1	RNF213	17	78348328	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	595145	78348328	2846882	100	41571											
DSG4	147409	broad.mit.edu	37	chr18	28968849	28968849	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttccacagatctattgccggGctctgaattcacggggtgaa	9	11	11	10	2	3	3	1	2	2	1	4	3	4	3	2	3	1	1	2	3	3	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr18:28968849G>A	uc002kwq.2	+	5	520	c.385G>A	c.(385-387)GCT>ACT	p.A129T	DSG4_uc002kwr.2_Missense_Mutation_p.A129T	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	129	Cadherin 1.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTATTGCCGGGCTCTGAATTC	0.368													32	71					0	0	0	0	A	28968849	A	A	28968849	3	1	227	1	0	0	0	0	1	0	0	0	4801	1203	42	4	403	4	DSG4	18	28968849	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08		28968849	49108399	101	41572											
ANGPTL4	51129	broad.mit.edu	37	chr19	8436124	8436124	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtggcctctcccactccaGgcgagttctggctgggtctg	4	10	14	13	1	3	0	0	0	3	0	5	2	4	0	3	4	0	2	3	4	0	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:8436124G>A	uc002mjq.1	+	6	953	c.758_splice	c.e6-1	p.G253_splice	ANGPTL4_uc002mjr.1_Splice_Site_p.G215_splice|ANGPTL4_uc010xkc.1_Splice_Site_p.G86_splice	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor						angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						TCCCACTCCAGGCGAGTTCTG	0.647													17	39					0	0	0	0	A	8436124	A	A	8436124	5	1	227	1	0	0	0	0	0	0	1	0	616	1014	35	4	779	4	ANGPTL4	19	8436124	Splice_Site	SNP	G	TCGA-CV-7177-01A-11D-2012-08		8436124	50692859	102	41573											
DOCK6	57572	broad.mit.edu	37	chr19	11313343	11313343	+	Frame_Shift_Del	DEL	G	-	-																															ctcatccaggtcaccgaagtGggcgccgtagaagcccacgc																										TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:11313343delG	uc002mqs.3	-	42	5319	c.5278delC	c.(5278-5280)CACfs	p.H1760fs	DOCK6_uc002mqr.3_Frame_Shift_Del_p.H160fs|DOCK6_uc010xlq.1_Frame_Shift_Del_p.H1099fs	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1760	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TCACCGAAGTGGGCGCCGTAG	0.617													---	---	---								-	11313343	-	-	11313343	7	5	227	1	0	1	0	1	0	0	0	0	4713	1348	47	0	893	0	DOCK6	19	11313343	Frame_Shift_Del	DEL	G	TCGA-CV-7177-01A-11D-2012-08	2877219	11313343	47815640	103	41574											
NOTCH3	4854	broad.mit.edu	37	chr19	15272483	15272483	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacagcagcttggcagcctCatagctgccctcgcgggcgg	7	6	13	15	3	1	0	1	0	0	0	2	0	1	0	2	3	6	4	2	3	2	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:15272483C>A	uc002nan.2	-	33	6032	c.5956G>T	c.(5956-5958)GAG>TAG	p.E1986*		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1986	ANK 5.|Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TTGGCAGCCTCATAGCTGCCC	0.627													3	13					0.004672	0.00510275	1	0	A	15272483	A	A	15272483	4	1	227	1	0	0	0	0	0	1	0	0	10604	835	29	2	1013	2	NOTCH3	19	15272483	Nonsense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	3959140	15272483	43856500	104	41575											
ZNF626	199777	broad.mit.edu	37	chr19	20807482	20807482	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttaaaagctttgccacattCttcacatttgtagggtttct	9	17	6	9	0	3	0	1	0	2	0	3	0	3	0	1	1	2	3	1	1	3	7			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:20807482C>A	uc002npb.1	-	4	1351	c.1201G>T	c.(1201-1203)GAA>TAA	p.E401*	ZNF626_uc002npc.1_Nonsense_Mutation_p.E325*	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	401	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTGCCACATTCTTCACATTTG	0.398													22	70					2.27731e-05	2.67714e-05	1	0	A	20807482	A	A	20807482	4	1	227	1	0	0	0	0	0	1	0	0	18117	922	32	2	389	2	ZNF626	19	20807482	Nonsense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	5534999	20807482	38321501	105	41576											
ZNF208	7757	broad.mit.edu	37	chr19	22154781	22154781	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccagtgtgaattttcttatGttccataaggtttgatgacc	9	17	8	7	0	1	3	0	3	1	0	3	3	3	3	3	1	0	2	3	1	3	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:22154781G>T	uc002nqp.2	-	6	2820	c.2671C>A	c.(2671-2673)CAT>AAT	p.H891N	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATTTTCTTATGTTCCATAAGG	0.408													20	62					5.35267e-07	6.54215e-07	1	0	T	22154781	T	T	22154781	3	4	227	1	0	0	0	0	1	0	0	0	17833	1377	48	4	791	4	ZNF208	19	22154781	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	1347299	22154781	36974202	106	41577											
EID2	163126	broad.mit.edu	37	chr19	40030624	40030624	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctgtgccggggccggctcCcgcctcccgcggcctacctc	1	6	14	20	5	0	0	0	0	0	0	3	0	2	0	7	5	2	2	7	5	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:40030624C>T	uc002oma.2	-	1	215	c.96G>A	c.(94-96)CGG>CGA	p.R32R		NM_153232	NP_694964	Q8N6I1	EID2_HUMAN	CREBBP/EP300 inhibitor 2	32					cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding				0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			GGGCCGGCTCCCGCCTCCCGC	0.502													15	23					0	0	0	0	T	40030624	T	T	40030624	2	4	227	1	0	0	0	0	0	0	0	1	5009	610	22	4		4	EID2	19	40030624	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	17875843	40030624	19098359	107	41578											
ZNF574	64763	broad.mit.edu	37	chr19	42584413	42584413	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacaggagagcggccctaccGgtgtggggactgtggcaagg	8	5	18	10	2	0	1	0	0	0	1	0	3	0	2	2	7	2	1	2	7	2	1	rs147085110		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:42584413G>A	uc002osm.3	+	2	1824	c.1655G>A	c.(1654-1656)CGG>CAG	p.R552Q	ZNF574_uc002osk.3_Missense_Mutation_p.R642Q	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	552	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CGGCCCTACCGGTGTGGGGAC	0.657													51	87					0	0	0	0	A	42584413	A	A	42584413	3	1	227	1	0	0	0	0	1	0	0	0	18073	1116	39	1	1657	1	ZNF574	19	42584413	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	2553789	42584413	16544570	108	41579											
TMEM145	284339	broad.mit.edu	37	chr19	42819348	42819348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccaaatcggcagggatcctgGagacagatgtgaccttcctc	10	8	11	12	1	0	3	0	1	0	2	4	5	2	4	4	3	0	1	4	3	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:42819348G>A	uc002otk.1	+	7	566	c.514G>A	c.(514-516)GAG>AAG	p.E172K		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	172						integral to membrane					0		Prostate(69;0.00682)				AGGGATCCTGGAGACAGATGT	0.448													18	40					0	0	0	0	A	42819348	A	A	42819348	3	1	227	1	0	0	0	0	1	0	0	0	16125	1175	41	2	540	2	TMEM145	19	42819348	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	234935	42819348	16309635	109	41580											
ZNF845	91664	broad.mit.edu	37	chr19	53855637	53855637	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagcacttatttaccatcAagcaatccatggtataggga	13	11	8	9	0	2	0	2	0	0	0	3	1	3	1	2	2	3	3	2	2	6	5			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:53855637A>G	uc010ydv.1	+	4	1826	c.1709A>G	c.(1708-1710)CAA>CGA	p.Q570R	ZNF845_uc010ydw.1_Missense_Mutation_p.Q570R	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	570	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTACCATCAAGCAATCCAT	0.398													4	41					0	0	0	0	G	53855637	G	G	53855637	3	3	227	1	0	0	0	0	1	0	0	0	18258	130	5	5	1719	5	ZNF845	19	53855637	Missense_Mutation	SNP	A	TCGA-CV-7177-01A-11D-2012-08	11036289	53855637	5273346	110	41581											
MBOAT7	79143	broad.mit.edu	37	chr19	54678113	54678113	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtaggcgctcagcagcatGgtccaggcgctcctgaggag	8	6	15	12	2	1	1	1	1	0	0	3	2	3	2	2	4	2	5	2	4	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:54678113G>A	uc002qdq.2	-	9	1310	c.1044C>T	c.(1042-1044)ACC>ACT	p.T348T	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Silent_p.T32T|MBOAT7_uc010yem.1_Silent_p.T330T|MBOAT7_uc002qdr.2_Silent_p.T348T|MBOAT7_uc002qds.2_Silent_p.T275T|MBOAT7_uc010yen.1_Silent_p.T275T	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	348					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCAGCAGCATGGTCCAGGCGC	0.488													11	25					0	0	0	0	A	54678113	A	A	54678113	2	1	227	1	0	0	0	0	0	0	0	1	9411	1335	47	4		4	MBOAT7	19	54678113	Silent	SNP	G	TCGA-CV-7177-01A-11D-2012-08	822476	54678113	4450870	111	41582											
NLRP13	126204	broad.mit.edu	37	chr19	56424476	56424476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcttcccaacccctgccCtccccaccaagactatcgtc	7	9	5	20	1	1	1	0	0	1	1	5	1	3	1	7	1	2	0	7	1	3	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:56424476C>T	uc010ygg.1	-	5	732	c.707G>A	c.(706-708)AGG>AAG	p.R236K		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	236	NACHT.|ATP (Potential).						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		AACCCCTGCCCTCCCCACCAA	0.507													4	130					0	0	0	0	T	56424476	T	T	56424476	3	4	227	1	0	0	0	0	1	0	0	0	10529	681	24	4	2450	4	NLRP13	19	56424476	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	1746363	56424476	2704507	112	41583											
ATRN	8455	broad.mit.edu	37	chr20	3575209	3575209	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaagggcgtcaagggggacGagtgccagctgtgagtacca	10	5	16	10	2	1	1	1	1	0	0	1	3	1	2	3	3	3	2	3	3	3	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:3575209G>A	uc002wim.2	+	20	3496	c.3406G>A	c.(3406-3408)GAG>AAG	p.E1136K	ATRN_uc002wil.2_Missense_Mutation_p.E1136K	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1136	Extracellular (Potential).|Laminin EGF-like 2.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						CAAGGGGGACGAGTGCCAGCT	0.597													14	57					0	0	0	0	A	3575209	A	A	3575209	3	1	227	1	0	0	0	0	1	0	0	0	1208	1059	37	1	3484	1	ATRN	20	3575209	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08		3575209	59450311	113	41584											
ATRN	8455	broad.mit.edu	37	chr20	3605205	3605205	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atggacctggtacagttcttCgtgactttcttcaggtaatt	8	16	9	8	1	3	1	1	1	2	0	4	2	3	2	1	3	1	3	1	3	2	7			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:3605205C>T	uc002wim.2	+	25	3939	c.3849C>T	c.(3847-3849)TTC>TTT	p.F1283F		NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1283	Helical; (Potential).				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						TACAGTTCTTCGTGACTTTCT	0.388													34	197					0	0	0	0	T	3605205	T	T	3605205	2	4	227	1	0	0	0	0	0	0	0	1	1208	883	31	1		1	ATRN	20	3605205	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	29996	3605205	59420315	114	41585											
ASXL1	171023	broad.mit.edu	37	chr20	31023531	31023531	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggatacagcctctgactttGaaggtcacctcacggaggac	10	8	11	12	2	3	2	2	2	1	0	3	5	3	5	2	4	2	0	2	4	2	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:31023531G>T	uc002wxs.2	+	12	3442	c.3016G>T	c.(3016-3018)GAA>TAA	p.E1006*	ASXL1_uc010geb.2_Nonsense_Mutation_p.E897*	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1006					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CTCTGACTTTGAAGGTCACCT	0.502			F|N|Mis		MDS|CMML								32	53					8.16721e-17	1.02256e-16	1	0	T	31023531	T	T	31023531	4	4	227	1	0	0	0	0	0	1	0	0	1068	1291	45	2	3072	2	ASXL1	20	31023531	Nonsense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	27418326	31023531	32001989	115	41586											
MYH7B	57644	broad.mit.edu	37	chr20	33589835	33589835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggagcgggcagacatggcgGaaacccaggccaacaagctg	13	2	15	11	2	0	1	0	0	0	1	0	3	0	3	2	5	4	2	2	5	3	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:33589835G>A	uc002xbi.1	+	42	5979	c.5887G>A	c.(5887-5889)GAA>AAA	p.E1963K		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1921	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGACATGGCGGAAACCCAGGC	0.672													14	62					0	0	0	0	A	33589835	A	A	33589835	3	1	227	1	0	0	0	0	1	0	0	0	10093	1175	41	2	6053	2	MYH7B	20	33589835	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	2566304	33589835	29435685	116	41587											
RALGAPB	57148	broad.mit.edu	37	chr20	37202933	37202933	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggatgattgtcagcaggcGagctcttggtaaggtcttca	8	12	14	7	1	4	1	2	1	2	0	4	3	4	2	0	4	2	3	0	4	1	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:37202933G>A	uc002xiw.2	+	29	4540	c.4283G>A	c.(4282-4284)CGA>CAA	p.R1428Q	RALGAPB_uc002xix.2_Missense_Mutation_p.R1425Q|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Missense_Mutation_p.R1207Q	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1428					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						GTCAGCAGGCGAGCTCTTGGT	0.358													9	154					0	0	0	0	A	37202933	A	A	37202933	3	1	227	1	0	0	0	0	1	0	0	0	13080	1058	37	1	4393	1	RALGAPB	20	37202933	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	3613098	37202933	25822587	117	41588											
OSBPL2	9885	broad.mit.edu	37	chr20	60835171	60835171	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctcaagagaacggaattCagaaacacaggtatgttctc	14	9	8	10	1	3	2	2	0	2	2	5	4	3	3	1	2	2	2	1	2	5	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:60835171C>G	uc002yck.1	+	3	374	c.172C>G	c.(172-174)CAG>GAG	p.Q58E	OSBPL2_uc002ycl.1_Missense_Mutation_p.Q46E|OSBPL2_uc011aah.1_Intron	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	58					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GAACGGAATTCAGAAACACAG	0.453													18	58					0	0	0	0	G	60835171	G	G	60835171	3	3	227	1	0	0	0	0	1	0	0	0	11332	827	29	2	178	2	OSBPL2	20	60835171	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	23632238	60835171	2190349	118	41589											
SLC17A9	63910	broad.mit.edu	37	chr20	61594660	61594660	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggtgtcctggcccaaagcCggccggtgtccaggcacaac	7	6	14	14	2	0	0	0	0	0	0	2	0	2	0	5	5	2	1	5	5	2	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:61594660C>T	uc002yea.3	+	6	848	c.664C>T	c.(664-666)CGG>TGG	p.R222W	SLC17A9_uc002ydz.3_Missense_Mutation_p.R216W|SLC17A9_uc011aap.1_Missense_Mutation_p.R242W	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	222					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						GGCCCAAAGCCGGCCGGTGTC	0.637													19	42					0	0	0	0	T	61594660	T	T	61594660	3	4	227	1	0	0	0	0	1	0	0	0	14489	643	23	1	686	1	SLC17A9	20	61594660	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	759489	61594660	1430860	119	41590											
WDR4	10785	broad.mit.edu	37	chr21	44299570	44299570	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgccccgcaccaccaacgtCtgcccgcacaacgccagtcc	8	3	7	23	5	1	0	0	0	1	0	2	0	2	0	8	0	3	2	8	0	2	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr21:44299570C>G	uc002zci.2	-	1	109	c.36G>C	c.(34-36)CAG>CAC	p.Q12H	WDR4_uc002zck.1_Missense_Mutation_p.Q12H|WDR4_uc002zcl.1_Intron|WDR4_uc010gpg.1_Missense_Mutation_p.Q12H|WDR4_uc011aew.1_Intron|WDR4_uc010gph.1_5'UTR	NM_033661	NP_387510	P57081	WDR4_HUMAN	WD repeat domain 4 protein	12					tRNA modification	cytoplasm|nucleoplasm	protein binding			ovary(1)	1				Colorectal(79;0.0165)|Lung(125;0.0484)|STAD - Stomach adenocarcinoma(101;0.0624)|COAD - Colon adenocarcinoma(84;0.128)|LUSC - Lung squamous cell carcinoma(216;0.244)		CCACCAACGTCTGCCCGCACA	0.682													37	60					0	0	0	0	G	44299570	G	G	44299570	3	3	227	1	0	0	0	0	1	0	0	0	17361	912	32	2	1246	2	WDR4	21	44299570	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08		44299570	3830325	120	41591											
TSSK2	23617	broad.mit.edu	37	chr22	19118994	19118994	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcctacgcaaaagtcaaaTctgcctactctgagcgcctc	10	10	7	14	2	3	1	1	1	2	0	5	1	4	1	3	0	4	2	3	0	5	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr22:19118994T>C	uc002zow.2	+	1	674	c.82T>C	c.(82-84)TCT>CCT	p.S28P	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	28	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					AAAAGTCAAATCTGCCTACTC	0.507													14	34					0	0	0	0	C	19118994	C	C	19118994	3	2	227	1	0	0	0	0	1	0	0	0	16736	1435	50	5	84	5	TSSK2	22	19118994	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08		19118994	32185572	121	41592											
TUBGCP6	85378	broad.mit.edu	37	chr22	50671941	50671941	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtcaggtaaggctcctctCtgtggccaggggggctgcga	5	8	16	12	2	2	0	1	0	1	0	4	1	3	0	3	6	1	3	3	6	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr22:50671941C>T	uc003bkb.1	-	3	1432	c.920G>A	c.(919-921)AGA>AAA	p.R307K	TUBGCP6_uc010har.1_Missense_Mutation_p.R307K|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	307					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGGCTCCTCTCTGTGGCCAGG	0.637													3	12					0	0	0	0	T	50671941	T	T	50671941	3	4	227	1	0	0	0	0	1	0	0	0	16838	913	32	2	4631	2	TUBGCP6	22	50671941	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	31552947	50671941	632625	122	41593											
SBF1	6305	broad.mit.edu	37	chr22	50897810	50897810	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccaggctactcgagtccgCctgggactggcctgggggag	5	7	16	13	2	0	0	0	0	0	0	3	3	2	2	4	5	1	1	4	5	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr22:50897810C>A	uc003blh.2	-	28	3895	c.3700G>T	c.(3700-3702)GCG>TCG	p.A1234S	SBF1_uc011arx.1_Missense_Mutation_p.A898S	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1234	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CTCGAGTCCGCCTGGGACTGG	0.512													16	18					0.00316338	0.00347972	1	0	A	50897810	A	A	50897810	3	1	227	1	0	0	0	0	1	0	0	0	13923	739	26	4	2037	4	SBF1	22	50897810	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	225869	50897810	406756	123	41594											
FRMPD4	9758	broad.mit.edu	37	chrX	12734834	12734834	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgacgcggaggacgaggaCgaggtgagctgcgaggagga	11	3	21	6	5	0	2	0	2	0	0	0	11	0	7	0	6	2	1	0	6	0	0			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:12734834C>T	uc004cuz.1	+	15	2762	c.2256C>T	c.(2254-2256)GAC>GAT	p.D752D	FRMPD4_uc011mij.1_Silent_p.D744D	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	752					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGGACGAGGACGAGGTGAGCT	0.582													6	142					0	0	0	0	T	12734834	T	T	12734834	2	4	227	1	0	0	0	0	0	0	0	1	6093	535	19	1		1	FRMPD4	23	12734834	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08		12734834	142535726	124	41595											
KDM6A	7403	broad.mit.edu	37	chrX	44949094	44949094	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgacctggagatttggtcTggataaatgcaggcactgtt	10	11	13	7	1	1	1	0	0	1	1	1	4	1	2	1	4	2	3	1	4	2	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:44949094T>A	uc004dge.3	+	25	4030	c.3655T>A	c.(3655-3657)TGG>AGG	p.W1219R	KDM6A_uc011mkz.1_Missense_Mutation_p.W1271R|KDM6A_uc011mla.1_Missense_Mutation_p.W1174R|KDM6A_uc011mlb.1_Missense_Mutation_p.W1226R|KDM6A_uc011mlc.1_Missense_Mutation_p.W923R|KDM6A_uc011mld.1_Missense_Mutation_p.W858R	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1219	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AGATTTGGTCTGGATAAATGC	0.408			D|N|F|S		renal|oesophageal SCC|MM								7	34					0	0	0	0	A	44949094	A	A	44949094	3	1	227	1	0	0	0	0	1	0	0	0	8176	1580	55	5	3753	5	KDM6A	23	44949094	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	32214260	44949094	110321466	125	41596											
CCDC120	90060	broad.mit.edu	37	chrX	48921913	48921913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaacaggagctggctcttGaggccctggaacgcgaggtg	8	6	15	12	2	1	1	0	1	1	0	1	4	1	3	2	5	3	2	2	5	2	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:48921913G>A	uc010nik.2	+	6	844	c.337G>A	c.(337-339)GAG>AAG	p.E113K	CCDC120_uc011mmq.1_Missense_Mutation_p.E101K|CCDC120_uc004dmf.2_Missense_Mutation_p.E113K|CCDC120_uc010nil.2_Missense_Mutation_p.E113K|CCDC120_uc011mmr.1_Missense_Mutation_p.E113K|CCDC120_uc011mms.1_Missense_Mutation_p.E101K	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	113	Potential.						protein binding			pancreas(1)	1						GCTGGCTCTTGAGGCCCTGGA	0.677													4	1					0	0	0	0	A	48921913	A	A	48921913	3	1	227	1	0	0	0	0	1	0	0	0	2768	1291	45	2	351	2	CCDC120	23	48921913	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	3972819	48921913	106348647	126	41597											
CLCN5	1184	broad.mit.edu	37	chrX	49854987	49854987	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcataagaccctggcaatGgatgtgatgaaaccccggag	12	7	12	10	1	1	3	1	2	0	1	1	5	1	5	3	3	1	2	3	3	3	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:49854987G>A	uc004dos.1	+	10	1997	c.1749G>A	c.(1747-1749)ATG>ATA	p.M583I	CLCN5_uc004dor.1_Missense_Mutation_p.M653I|CLCN5_uc004doq.1_Missense_Mutation_p.M653I|CLCN5_uc004dot.1_Missense_Mutation_p.M583I	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	583	Cytoplasmic (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					CCCTGGCAATGGATGTGATGA	0.468													4	65					0	0	0	0	A	49854987	A	A	49854987	3	1	227	1	0	0	0	0	1	0	0	0	3481	1348	47	4	2001	4	CLCN5	23	49854987	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	933074	49854987	105415573	127	41598											
CHIC1	53344	broad.mit.edu	37	chrX	72797282	72797282	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgatactgaatttccctcCgttctaacagggaaggtaag	11	13	9	8	1	1	2	0	2	1	0	3	3	3	3	2	2	2	2	2	2	5	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:72797282C>G	uc004ebk.3	+	2	473	c.336C>G	c.(334-336)TCC>TCG	p.S112S	CHIC1_uc010nlo.2_RNA|CHIC1_uc011mql.1_Silent_p.S112S|CHIC1_uc004ebl.3_Silent_p.S112S	NM_001039840	NP_001034929	Q5VXU3	CHIC1_HUMAN	cysteine-rich hydrophobic domain 1	112						cytoplasmic membrane-bounded vesicle|plasma membrane					0	Renal(35;0.156)					AATTTCCCTCCGTTCTAACAG	0.343													18	138					0	0	0	0	G	72797282	G	G	72797282	2	3	227	1	0	0	0	0	0	0	0	1	3358	639	23	3		3	CHIC1	23	72797282	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	22942295	72797282	82473278	128	41599											
RPS6KA6	27330	broad.mit.edu	37	chrX	83442984	83442986	+	5'Flank	DEL	CCG	-	-																															atcctgtctattgaactggcCcgccgccgccgccgccgccg																								rs111507044		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:83442984_83442986delCCG	uc004eej.1	-						RPS6KA6_uc011mqt.1_5'Flank|RPS6KA6_uc011mqu.1_5'Flank	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6						axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TTGAACTGGCccgccgccgccgc	0.567													---	---	---								-	83442986	-	-	83442984	6	5	227	0	1	1	0	1	0	0	0	0	13720	638	22	0		0	RPS6KA6	23	83442984	5'Flank	DEL	CCG	TCGA-CV-7177-01A-11D-2012-08	10645702	83442984	71827576	129	41600											
KLHL4	56062	broad.mit.edu	37	chrX	86888820	86888820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagctatctaaatactgtaGaaagatgggaccctgaggga	14	8	13	6	0	1	3	0	1	1	2	1	6	1	6	1	3	2	2	1	3	6	4			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:86888820G>A	uc004efb.2	+	8	1803	c.1621G>A	c.(1621-1623)GAA>AAA	p.E541K	KLHL4_uc004efa.2_Missense_Mutation_p.E541K	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	541	Kelch 3.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AAATACTGTAGAAAGATGGGA	0.413													4	59					0	0	0	0	A	86888820	A	A	86888820	3	1	227	1	0	0	0	0	1	0	0	0	8430	943	33	2	1651	2	KLHL4	23	86888820	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	3445836	86888820	68381740	130	41601											
GPRASP2	114928	broad.mit.edu	37	chrX	101971267	101971267	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatcctccaggccccaaacCtgggacgaggtcactgttga	9	7	11	14	1	1	1	1	1	0	0	3	3	3	2	5	3	1	2	5	3	1	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:101971267C>T	uc004ejk.2	+	4	2804	c.1470C>T	c.(1468-1470)ACC>ACT	p.T490T	GPRASP2_uc004ejl.2_Silent_p.T490T|GPRASP2_uc004ejm.2_Silent_p.T490T|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	490						cytoplasm	protein binding			ovary(1)	1						GGCCCCAAACCTGGGACGAGG	0.507													30	121					0	0	0	0	T	101971267	T	T	101971267	2	4	227	1	0	0	0	0	0	0	0	1	6762	668	24	4		4	GPRASP2	23	101971267	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	15082447	101971267	53299293	131	41602											
PRPS1	5631	broad.mit.edu	37	chrX	106888430	106888430	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctccattgcagacaggcTgaatgtggactttgccttga	9	11	11	10	0	0	3	0	2	0	1	1	5	1	4	3	2	2	2	3	2	1	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:106888430T>C	uc004ene.3	+	5	759	c.554T>C	c.(553-555)CTG>CCG	p.L185P	PRPS1_uc010npg.2_Missense_Mutation_p.L152P|PRPS1_uc011msj.1_5'UTR	NM_002764	NP_002755	P60891	PRPS1_HUMAN	phosphoribosyl pyrophosphate synthetase 1	185					5-phosphoribose 1-diphosphate biosynthetic process|hypoxanthine biosynthetic process|nervous system development|nucleoside metabolic process|purine nucleotide biosynthetic process|pyrimidine nucleotide biosynthetic process|ribonucleoside monophosphate biosynthetic process|urate biosynthetic process	cytosol	ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(3)|large_intestine(1)	4						GCAGACAGGCTGAATGTGGAC	0.438													9	286					0	0	0	0	C	106888430	C	C	106888430	3	2	227	1	0	0	0	0	1	0	0	0	12640	1580	55	5	572	5	PRPS1	23	106888430	Missense_Mutation	SNP	T	TCGA-CV-7177-01A-11D-2012-08	4917163	106888430	48382130	132	41603											
IRS4	8471	broad.mit.edu	37	chrX	107978579	107978579	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggctctgtattcgtctgcAcacaaggctctcatcttctc	6	13	8	14	2	5	0	1	0	5	0	8	0	5	0	0	2	1	4	0	2	2	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:107978579A>G	uc004eoc.2	-	1	1029	c.996T>C	c.(994-996)TGT>TGC	p.C332C		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	332	IRS-type PTB.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						ATTCGTCTGCACACAAGGCTC	0.587													100	199					0	0	0	0	G	107978579	G	G	107978579	2	3	227	1	0	0	0	0	0	0	0	1	7881	157	6	5		5	IRS4	23	107978579	Silent	SNP	A	TCGA-CV-7177-01A-11D-2012-08	1090149	107978579	47291981	133	41604											
DCX	1641	broad.mit.edu	37	chrX	110644290	110644290	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggcttctgtgatatcagtGaggacttgctcaaaagagtg	11	12	12	6	0	3	3	2	2	1	1	3	4	3	4	0	2	1	2	0	2	3	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:110644290G>C	uc004epd.2	-	3	1048	c.876C>G	c.(874-876)CTC>CTG	p.L292L	DCX_uc011msv.1_Silent_p.L292L|DCX_uc004epe.2_Silent_p.L211L|DCX_uc004epf.2_Silent_p.L211L|DCX_uc004epg.2_Silent_p.L211L	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	292	Doublecortin 2.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						TGATATCAGTGAGGACTTGCT	0.493													62	100					0	0	0	0	C	110644290	C	C	110644290	2	2	227	1	0	0	0	0	0	0	0	1	4335	1277	45	2		2	DCX	23	110644290	Silent	SNP	G	TCGA-CV-7177-01A-11D-2012-08	2665711	110644290	44626270	134	41605											
ALG13	79868	broad.mit.edu	37	chrX	110979971	110979971	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatattgcagcagttgcagcTtcctgtgccaataatgttcc	10	13	8	10	0	0	0	0	0	0	0	2	0	2	0	3	0	5	6	3	0	4	6			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:110979971T>C	uc011msy.1	+	23	2593	c.2559T>C	c.(2557-2559)GCT>GCC	p.A853A	ALG13_uc011msx.1_Silent_p.A749A|ALG13_uc011msz.1_Silent_p.A775A|ALG13_uc011mta.1_Silent_p.A749A|ALG13_uc011mtb.1_Silent_p.A749A			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	853					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						CAGTTGCAGCTTCCTGTGCCA	0.403													21	171					0	0	0	0	C	110979971	C	C	110979971	2	2	227	1	0	0	0	0	0	0	0	1	515	1596	56	5		5	ALG13	23	110979971	Silent	SNP	T	TCGA-CV-7177-01A-11D-2012-08	335681	110979971	44290589	135	41606											
AKAP14	158798	broad.mit.edu	37	chrX	119054501	119054501	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gttcgctttcgagaaaactgGcagaagaatcttactgatgc	12	11	10	8	2	1	4	0	1	1	3	3	5	1	4	0	1	3	3	0	1	5	3			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:119054501G>T	uc004ese.2	+	7	663	c.525G>T	c.(523-525)TGG>TGT	p.W175C	AKAP14_uc004esf.2_Missense_Mutation_p.W115C	NM_178813	NP_848928	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14 isoform a	175						cytoplasm					0						GAGAAAACTGGCAGAAGAATC	0.338													19	39					1.15919e-05	1.37319e-05	1	0	T	119054501	T	T	119054501	3	4	227	1	0	0	0	0	1	0	0	0	450	1212	42	4	552	4	AKAP14	23	119054501	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	8074530	119054501	36216059	136	41607											
CUL4B	8450	broad.mit.edu	37	chrX	119666336	119666336	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtttatgtttgaaatcatCattacaaatgaacttgtcac	15	15	5	6	0	3	2	3	2	0	0	3	2	3	2	0	0	2	2	0	0	6	5			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:119666336C>G	uc004esw.2	-	20	2871	c.2434G>C	c.(2434-2436)GAT>CAT	p.D812H	CUL4B_uc010nqq.2_Missense_Mutation_p.D513H|CUL4B_uc004esv.2_Missense_Mutation_p.D794H	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	812					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						TTGAAATCATCATTACAAATG	0.368													15	45					0	0	0	0	G	119666336	G	G	119666336	3	3	227	1	0	0	0	0	1	0	0	0	4075	826	29	2	319	2	CUL4B	23	119666336	Missense_Mutation	SNP	C	TCGA-CV-7177-01A-11D-2012-08	611835	119666336	35604224	137	41608											
GRIA3	2892	broad.mit.edu	37	chrX	122459926	122459926	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcagcagtgcaaaacaactgGcaagtaacagcaaggtctgt	15	6	11	9	0	1	0	0	0	1	0	1	0	1	0	0	2	6	6	0	2	6	1			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:122459926G>T	uc004etq.3	+	5	851	c.558G>T	c.(556-558)TGG>TGT	p.W186C	GRIA3_uc004etr.3_Missense_Mutation_p.W186C|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.W170C	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	186	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	AAAACAACTGGCAAGTAACAG	0.418													15	46					0.000308642	0.000344427	1	0	T	122459926	T	T	122459926	3	4	227	1	0	0	0	0	1	0	0	0	6808	1212	42	4	572	4	GRIA3	23	122459926	Missense_Mutation	SNP	G	TCGA-CV-7177-01A-11D-2012-08	2793590	122459926	32810634	138	41609											
PLXNA3	55558	broad.mit.edu	37	chrX	153698126	153698126	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acccgctccctcagccgctaCggtaggtgtcctcagtgtgg	5	9	12	15	3	2	0	2	0	0	0	4	0	4	0	4	3	2	3	4	3	2	2			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:153698126C>T	uc004flm.2	+	28	4967	c.4794C>T	c.(4792-4794)TAC>TAT	p.Y1598Y		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1598	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCAGCCGCTACGGTAGGTGTC	0.582													17	49					0	0	0	0	T	153698126	T	T	153698126	2	4	227	1	0	0	0	0	0	0	0	1	12176	550	19	1		1	PLXNA3	23	153698126	Silent	SNP	C	TCGA-CV-7177-01A-11D-2012-08	31238200	153698126	1572434	139	41610											
LIN28A	79727	broad.mit.edu	37	chr1	26752814	26752814	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaagtgccacttctgccaGagcatcagccatatggtagc	12	8	10	11	0	2	2	1	0	1	2	2	2	2	2	3	1	5	2	3	1	4	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:26752814G>C	uc001bmj.2	+	4	609	c.495G>C	c.(493-495)CAG>CAC	p.Q165H	LIN28A_uc001bmi.1_RNA	NM_024674	NP_078950	Q9H9Z2	LN28A_HUMAN	lin-28 homolog	165	CCHC-type 2.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)	1						ACTTCTGCCAGAGCATCAGCC	0.532													9	54					0	0	0	0	C	26752814	C	C	26752814	3	2	228	1	0	0	0	0	1	0	0	0	8847	933	33	2	509	2	LIN28A	1	26752814	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08		26752814	222497807	1	41611											
COL9A2	1298	broad.mit.edu	37	chr1	40771397	40771397	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcatttacctctttcccaGggggaccagagaatccagga	10	8	12	11	0	1	1	0	0	1	1	3	4	3	3	4	4	1	1	4	4	2	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:40771397G>A	uc001cfh.1	-	21	1167	c.1097C>T	c.(1096-1098)CCT>CTT	p.P366L	COL9A2_uc001cfi.1_Missense_Mutation_p.P185L	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	366	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CTCTTTCCCAGGGGGACCAGA	0.557													11	43					0	0	0	0	A	40771397	A	A	40771397	3	1	228	1	0	0	0	0	1	0	0	0	3723	1000	35	4	1020	4	COL9A2	1	40771397	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	14018583	40771397	208479224	2	41612											
IL12RB2	3595	broad.mit.edu	37	chr1	67861599	67861599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctacttaccctccaacataGatgacctcccctcacatgag	11	9	5	16	0	1	3	1	2	0	1	3	3	3	3	5	0	3	1	5	0	4	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:67861599G>A	uc001ddu.2	+	16	3056	c.2416G>A	c.(2416-2418)GAT>AAT	p.D806N	IL12RB2_uc010oqi.1_3'UTR|IL12RB2_uc010oqj.1_3'UTR|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.D720N|IL12RB2_uc010oqm.1_3'UTR|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	806	Cytoplasmic (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						CTCCAACATAGATGACCTCCC	0.577													62	175					0	0	0	0	A	67861599	A	A	67861599	3	1	228	1	0	0	0	0	1	0	0	0	7666	942	33	2	2474	2	IL12RB2	1	67861599	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	27090202	67861599	181389022	3	41613											
ZNF644	84146	broad.mit.edu	37	chr1	91403926	91403926	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctggtgatacaacatgacgGgcttcatagcttaatcctgc	10	12	9	10	1	2	2	1	2	1	0	3	2	3	2	1	2	4	2	1	2	4	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:91403926G>A	uc001dnw.2	-	3	3127	c.2985C>T	c.(2983-2985)GCC>GCT	p.A995A	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Silent_p.A995A	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	995					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		CAACATGACGGGCTTCATAGC	0.428													17	56					0	0	0	0	A	91403926	A	A	91403926	2	1	228	1	0	0	0	0	0	0	0	1	18127	1219	43	4		4	ZNF644	1	91403926	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08	23542327	91403926	157846695	4	41614											
ZNF644	84146	broad.mit.edu	37	chr1	91405606	91405606	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agatggcgaaagtgactattCccatctaaatgatacatcat	15	11	7	8	1	2	3	1	2	1	1	3	4	3	3	1	1	1	0	1	1	5	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:91405606C>T	uc001dnw.2	-	3	1447	c.1305G>A	c.(1303-1305)GGG>GGA	p.G435G	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Silent_p.G435G	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AGTGACTATTCCCATCTAAAT	0.413													20	56					0	0	0	0	T	91405606	T	T	91405606	2	4	228	1	0	0	0	0	0	0	0	1	18127	842	30	2		2	ZNF644	1	91405606	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	1680	91405606	157845015	5	41615											
DPYD	1806	broad.mit.edu	37	chr1	97770874	97770874	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctggccaaggtgtgccaTcagattttaatcccatcaga	10	11	9	11	0	2	2	2	0	0	2	3	2	3	2	3	2	2	1	3	2	2	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:97770874T>A	uc001drv.2	-	18	2377	c.2240A>T	c.(2239-2241)GAT>GTT	p.D747V		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	747					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AGGTGTGCCATCAGATTTTAA	0.478													23	66					0	0	0	0	A	97770874	A	A	97770874	3	1	228	1	0	0	0	0	1	0	0	0	4767	1435	50	5	861	5	DPYD	1	97770874	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	6365268	97770874	151479747	6	41616											
EPS8L3	79574	broad.mit.edu	37	chr1	110294748	110294748	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagttggggtccccaggctGagggtcatggttgtgtgtct	4	12	18	7	0	2	1	1	1	1	0	3	2	3	2	2	6	0	3	2	6	0	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:110294748G>A	uc001dyr.1	-	15	1448	c.1303C>T	c.(1303-1305)CAG>TAG	p.Q435*	EPS8L3_uc001dys.1_Intron|EPS8L3_uc001dyq.1_Nonsense_Mutation_p.Q436*|EPS8L3_uc009wfm.1_Intron|EPS8L3_uc009wfn.1_Intron	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	435						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		TCCCCAGGCTGAGGGTCATGG	0.562													36	133					0	0	0	0	A	110294748	A	A	110294748	4	1	228	1	0	0	0	0	0	1	0	0	5221	1299	45	2	498	2	EPS8L3	1	110294748	Nonsense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	12523874	110294748	138955873	7	41617											
NOTCH2	4853	broad.mit.edu	37	chr1	120539638	120539638	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctggaaggcagttgcactCaaaagtgaagtcaccagtct	13	8	10	10	0	3	1	2	1	1	0	3	2	3	2	2	2	1	3	2	2	4	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:120539638C>A	uc001eik.2	-	4	989	c.733G>T	c.(733-735)GAG>TAG	p.E245*	NOTCH2_uc001eil.2_Nonsense_Mutation_p.E245*|NOTCH2_uc001eim.3_Nonsense_Mutation_p.E162*	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	245	EGF-like 6.|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGTTGCACTCAAAAGTGAAG	0.547			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				7	31					0.000157383	0.00031575	1	0	A	120539638	A	A	120539638	4	1	228	1	0	0	0	0	0	1	0	0	10602	835	29	2	6806	2	NOTCH2	1	120539638	Nonsense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	10244890	120539638	128710983	8	41618											
ACP6	51205	broad.mit.edu	37	chr1	147131783	147131783	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcagggtggtctcatggtaTtgagagtcgtaaggagaata	11	12	14	4	1	2	2	2	1	1	2	4	4	2	2	0	4	0	2	0	4	4	5			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:147131783T>C	uc001epr.2	-	2	791	c.327A>G	c.(325-327)CAA>CAG	p.Q109Q	ACP6_uc009wjj.1_Intron	NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	109					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					TCTCATGGTATTGAGAGTCGT	0.517													12	89					0	0	0	0	C	147131783	C	C	147131783	2	2	228	1	0	0	0	0	0	0	0	1	165	1490	52	5		5	ACP6	1	147131783	Silent	SNP	T	TCGA-CV-7178-01A-21D-2012-08	26592145	147131783	102118838	9	41619											
ANP32E	81611	broad.mit.edu	37	chr1	150199019	150199019	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacctgcttcatcttcaTcttcatcctcatcctcatcc	7	15	2	17	0	7	1	5	1	2	0	10	1	10	1	4	0	2	1	4	0	1	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:150199019T>C	uc001etw.2	-	5	972	c.602A>G	c.(601-603)GAT>GGT	p.D201G	ANP32E_uc010pbt.1_RNA|ANP32E_uc010pbu.1_Missense_Mutation_p.D153G|ANP32E_uc010pbv.1_Missense_Mutation_p.D160G|ANP32E_uc001etv.3_Missense_Mutation_p.D201G|ANP32E_uc010pbw.1_Missense_Mutation_p.M146V	NM_030920	NP_112182	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	201	Asp/Glu-rich (highly acidic).					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity				0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ttcatcttcatcttcatcctc	0.308													29	65					0	0	0	0	C	150199019	C	C	150199019	3	2	228	1	0	0	0	0	1	0	0	0	709	1435	50	5	216	5	ANP32E	1	150199019	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	3067236	150199019	99051602	10	41620											
OR10J1	26476	broad.mit.edu	37	chr1	159410091	159410091	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcaggttacccttctgtgcTagaaaggtgccccacttctt	7	14	8	12	0	3	1	1	0	2	1	3	1	3	1	3	2	3	2	3	2	3	6			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:159410091T>C	uc010piv.1	+	1	543	c.543T>C	c.(541-543)GCT>GCC	p.A181A	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	181	Extracellular (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					CCTTCTGTGCTAGAAAGGTGC	0.493													64	154					0	0	0	0	C	159410091	C	C	159410091	2	2	228	1	0	0	0	0	0	0	0	1	10964	1509	53	5		5	OR10J1	1	159410091	Silent	SNP	T	TCGA-CV-7178-01A-21D-2012-08	9211072	159410091	89840530	11	41621											
PVRL4	81607	broad.mit.edu	37	chr1	161047483	161047483	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggaggctgccagggtcaggcCctggccctcttctagtgctg	4	9	15	13	0	3	0	1	0	2	0	3	1	3	1	3	5	2	2	3	5	1	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:161047483C>A	uc001fxo.2	-	3	789	c.490G>T	c.(490-492)GGC>TGC	p.G164C	PVRL4_uc010pjz.1_5'Flank	NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	164	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			AGGGTCAGGCCCTGGCCCTCT	0.627													12	57					6.40141e-05	0.000130882	1	0	A	161047483	A	A	161047483	3	1	228	1	0	0	0	0	1	0	0	0	12907	623	22	4	1070	4	PVRL4	1	161047483	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	1637392	161047483	88203138	12	41622											
KLHDC9	126823	broad.mit.edu	37	chr1	161069390	161069390	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctttctttctccccaaggaGgaaccacctgttgctcctca	7	12	6	16	0	3	0	1	0	2	0	5	2	4	2	6	2	2	2	6	2	2	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:161069390G>A	uc001fxr.2	+	3	862	c.690G>A	c.(688-690)GAG>GAA	p.E230E	KLHDC9_uc001fxq.2_5'UTR|KLHDC9_uc001fxs.2_Missense_Mutation_p.G237R	NM_152366	NP_689579	Q8NEP7	KLDC9_HUMAN	kelch/ankyrin repeat containing cyclin A1	230											0	all_cancers(52;1.28e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TCCCCAAGGAGGAACCACCTG	0.512													293	246					0	0	0	0	A	161069390	A	A	161069390	2	1	228	1	0	0	0	0	0	0	0	1	8403	1001	35	4		4	KLHDC9	1	161069390	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08	21907	161069390	88181231	13	41623											
ASPM	259266	broad.mit.edu	37	chr1	197070918	197070918	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtacatcctgaaagtagccTgaatgagaactgcagccctt	12	10	9	10	0	0	3	0	3	0	1	1	4	1	3	3	0	5	3	3	0	5	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:197070918T>G	uc001gtu.2	-	18	7720	c.7463A>C	c.(7462-7464)CAG>CCG	p.Q2488P	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.Q336P	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2488	IQ 26.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GAAAGTAGCCTGAATGAGAAC	0.363													15	112					0	0	0	0	G	197070918	G	G	197070918	3	3	228	1	0	0	0	0	1	0	0	0	1058	1580	55	5	3014	5	ASPM	1	197070918	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	36001528	197070918	52179703	14	41624											
KIF21B	23046	broad.mit.edu	37	chr1	200944027	200944027	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgcacacccagtccttgtgCgcattggggatttgctgtga	6	11	13	11	2	0	1	0	1	0	0	1	2	1	2	2	2	2	3	2	2	0	3	rs140999969		TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:200944027C>T	uc001gvs.1	-	34	4946	c.4629G>A	c.(4627-4629)GCG>GCA	p.A1543A	KIF21B_uc001gvr.1_Silent_p.A1530A|KIF21B_uc009wzl.1_Silent_p.A1543A|KIF21B_uc010ppn.1_Silent_p.A1530A	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1543	WD 6.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						AGTCCTTGTGCGCATTGGGGA	0.642													16	131					0	0	0	0	T	200944027	T	T	200944027	2	4	228	1	0	0	0	0	0	0	0	1	8328	755	27	1		1	KIF21B	1	200944027	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	3873109	200944027	48306594	15	41625											
CNTN2	6900	broad.mit.edu	37	chr1	205034931	205034931	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgcagaaggagaccattggGgatctgaccatcctgaacgc	11	7	13	10	1	1	4	0	2	1	2	2	6	2	5	3	3	2	1	3	3	2	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:205034931G>A	uc001hbr.2	+	14	1979	c.1710G>A	c.(1708-1710)GGG>GGA	p.G570G	CNTN2_uc001hbq.1_Silent_p.G461G|CNTN2_uc001hbs.2_Silent_p.G358G	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	570	Ig-like C2-type 6.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGACCATTGGGGATCTGACCA	0.642													9	71					0	0	0	0	A	205034931	A	A	205034931	2	1	228	1	0	0	0	0	0	0	0	1	3656	1219	43	4		4	CNTN2	1	205034931	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08	4090904	205034931	44215690	16	41626											
DSTYK	25778	broad.mit.edu	37	chr1	205130494	205130494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcttccgttttctctaaccGgcctgagtggccagcttcca	6	13	8	14	2	2	1	0	1	2	0	5	1	4	1	5	2	2	2	5	2	1	5			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:205130494G>A	uc001hbw.2	-	7	1904	c.1840C>T	c.(1840-1842)CGG>TGG	p.R614W	DSTYK_uc001hbx.2_Missense_Mutation_p.R614W|DSTYK_uc001hby.1_Missense_Mutation_p.R75W	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	614						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						TTCTCTAACCGGCCTGAGTGG	0.383													26	76					0	0	0	0	A	205130494	A	A	205130494	3	1	228	1	0	0	0	0	1	0	0	0	4807	1115	39	1	977	1	DSTYK	1	205130494	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	95563	205130494	44120127	17	41627											
DISP1	84976	broad.mit.edu	37	chr1	223177961	223177961	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgagaaggcaaagtgatcttCtctctgagtcgcgtgggctc	8	10	13	10	3	3	3	0	2	3	1	6	4	3	3	0	2	0	2	0	2	2	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:223177961C>T	uc001hnu.1	+	8	3369	c.3222C>T	c.(3220-3222)TTC>TTT	p.F1074F		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1074					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AAGTGATCTTCTCTCTGAGTC	0.587													24	78					0	0	0	0	T	223177961	T	T	223177961	2	4	228	1	0	0	0	0	0	0	0	1	4561	912	32	2		2	DISP1	1	223177961	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	18047467	223177961	26072660	18	41628											
WNT3A	89780	broad.mit.edu	37	chr1	228210572	228210572	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaactgcaccaccgtccaCgacagcctggccatcttcgg	8	7	10	16	3	1	0	0	0	1	0	3	2	2	1	5	3	3	1	5	3	1	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:228210572C>T	uc001hrq.1	+	2	354	c.276C>T	c.(274-276)CAC>CAT	p.H92H	WNT3A_uc001hrp.1_Silent_p.H92H	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	92					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)				CCACCGTCCACGACAGCCTGG	0.652													14	77					0	0	0	0	T	228210572	T	T	228210572	2	4	228	1	0	0	0	0	0	0	0	1	17457	535	19	1		1	WNT3A	1	228210572	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	5032611	228210572	21040049	19	41629											
FMN2	56776	broad.mit.edu	37	chr1	240555811	240555811	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttattttcttgcactttcagCcaaaattgaccaagaggcag	12	13	7	9	0	2	2	1	1	1	1	2	2	2	2	2	1	2	2	2	1	4	6			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr1:240555811C>A	uc010pyd.1	+	15	5084	c.4859C>A	c.(4858-4860)GCC>GAC	p.A1620D	FMN2_uc010pye.1_Missense_Mutation_p.A1624D|FMN2_uc010pyf.1_Missense_Mutation_p.A235D|FMN2_uc010pyg.1_Missense_Mutation_p.A216D	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1620	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCACTTTCAGCCAAAATTGAC	0.328													29	100					1.16021e-09	2.49951e-09	1	0	A	240555811	A	A	240555811	3	1	228	1	0	0	0	0	1	0	0	0	5982	753	26	4	4917	4	FMN2	1	240555811	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	12345239	240555811	8694810	20	41630											
CAD	790	broad.mit.edu	37	chr2	27457394	27457394	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctctgccccaggatgaccaGctgaaagttattgaatgcaa	12	10	9	10	0	1	3	0	3	1	0	2	4	1	4	3	1	3	3	3	1	4	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:27457394G>A	uc002rji.2	+	23	3789	c.3627G>A	c.(3625-3627)CAG>CAA	p.Q1209Q	CAD_uc010eyw.2_Silent_p.Q1146Q	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1209	CPSase B.|ATP-grasp 2.|CPSase (Carbamoyl-phosphate synthase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	AGGATGACCAGCTGAAAGTTA	0.383													35	158					0	0	0	0	A	27457394	A	A	27457394	2	1	228	1	0	0	0	0	0	0	0	1	2577	962	34	4		4	CAD	2	27457394	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08		27457394	215741979	21	41631											
SPRED2	200734	broad.mit.edu	37	chr2	65541019	65541019	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgacttgccccgggagggCtgcgtcttgatcacgctgcc	4	8	14	15	5	2	1	1	1	1	0	2	3	2	2	3	2	3	2	3	2	0	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:65541019C>T	uc002sdr.3	-	6	1408	c.873G>A	c.(871-873)CAG>CAA	p.Q291Q	SPRED2_uc010fcw.2_Silent_p.Q288Q	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	291					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CCCGGGAGGGCTGCGTCTTGA	0.662													21	96					0	0	0	0	T	65541019	T	T	65541019	2	4	228	1	0	0	0	0	0	0	0	1	15159	796	28	4		4	SPRED2	2	65541019	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	38083625	65541019	177658354	22	41632											
AUP1	550	broad.mit.edu	37	chr2	74755571	74755571	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accaggggtctctgaacttgCagggtaagaggttgtaccac	10	9	13	9	0	1	2	0	1	1	1	2	2	1	2	2	4	3	4	2	4	3	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:74755571C>A	uc010yrx.1	-	4	867	c.741G>T	c.(739-741)CTG>CTT	p.L247L	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_Silent_p.L190L|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Silent_p.L99L|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ57204, highly similar to Homo sapiens ancient ubiquitous protein 1 (AUP1), transcript variant 2, mRNA;	256	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						TCTGAACTTGCAGGGTAAGAG	0.527													17	44					9.7654e-05	0.000197151	1	0	A	74755571	A	A	74755571	2	1	228	1	0	0	0	0	0	0	0	1	1222	697	25	4		4	AUP1	2	74755571	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	9214552	74755571	168443802	23	41633											
ADRA2B	151	broad.mit.edu	37	chr2	96780623	96780623	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctggttgaagatggtgtaGataacagggttcagtgagct	10	12	14	5	0	1	4	1	2	0	2	2	4	2	4	1	3	2	4	1	3	3	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:96780623G>C	uc002svi.2	-	3	1275	c.1275C>G	c.(1273-1275)ATC>ATG	p.I425M		NM_000682	NP_000673	P18089	ADA2B_HUMAN	alpha-2B-adrenergic receptor	425	Helical; Name=7; (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			ovary(2)|lung(1)	3					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	AGATGGTGTAGATAACAGGGT	0.627													5	30					0	0	0	0	C	96780623	C	C	96780623	3	2	228	1	0	0	0	0	1	0	0	0	338	932	33	2	81	2	ADRA2B	2	96780623	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	22025052	96780623	146418750	24	41634											
FOXD4L1	200350	broad.mit.edu	37	chr2	114257536	114257536	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaacccccgcccaggccctCtgcttggggcccctgccctg	4	6	10	21	1	1	0	0	0	1	0	1	0	1	0	7	3	3	1	7	3	1	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:114257536C>G	uc002tjw.3	+	1	876	c.703C>G	c.(703-705)CTG>GTG	p.L235V		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	235	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CCCAGGCCCTCTGCTTGGGGC	0.726													28	113					0	0	0	0	G	114257536	G	G	114257536	3	3	228	1	0	0	0	0	1	0	0	0	6032	912	32	2	705	2	FOXD4L1	2	114257536	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	17476913	114257536	128941837	25	41635											
TTN	7273	broad.mit.edu	37	chr2	179427268	179427268	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttactcttccaggtgggaggGgtggttcagacactttaacg	8	12	13	8	1	2	1	1	0	1	1	3	2	3	2	1	5	2	1	1	5	2	5			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:179427268G>T	uc010zfg.1	-	275	76111	c.75887C>A	c.(75886-75888)CCC>CAC	p.P25296H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P18991H|TTN_uc010zfi.1_Missense_Mutation_p.P18924H|TTN_uc010zfj.1_Missense_Mutation_p.P18799H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26223							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGTGGGAGGGGTGGTTCAGA	0.448													12	55					3.07112e-06	6.40148e-06	1	0	T	179427268	T	T	179427268	3	4	228	1	0	0	0	0	1	0	0	0	16803	1232	43	4	24536	4	TTN	2	179427268	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	65169732	179427268	63772105	26	41636											
TTN	7273	broad.mit.edu	37	chr2	179638736	179638736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggccgtctttcatccagaCgccttccacactttccaagg	7	12	7	15	2	2	1	1	0	1	1	5	1	5	1	5	2	0	0	5	2	1	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:179638736C>T	uc010zfg.1	-	31	7383	c.7159G>A	c.(7159-7161)GTC>ATC	p.V2387I	TTN_uc010zfh.1_Missense_Mutation_p.V2341I|TTN_uc010zfi.1_Missense_Mutation_p.V2341I|TTN_uc010zfj.1_Missense_Mutation_p.V2341I|TTN_uc002unb.2_Missense_Mutation_p.V2387I|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2387							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATCCAGACGCCTTCCACA	0.463													21	107					0	0	0	0	T	179638736	T	T	179638736	3	4	228	1	0	0	0	0	1	0	0	0	16803	536	19	1	104157	1	TTN	2	179638736	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	211468	179638736	63560637	27	41637											
SF3B1	23451	broad.mit.edu	37	chr2	198272767	198272767	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaattcctcatcagaaagTgggcgatttctctcatcaat	11	14	6	10	1	6	1	4	0	2	1	8	2	7	1	1	1	0	0	1	1	3	3	rs71422649	byFrequency	TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:198272767T>C	uc002uue.2	-	9	1242	c.1194A>G	c.(1192-1194)CCA>CCG	p.P398P		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	398	Interaction with PPP1R8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CATCAGAAAGTGGGCGATTTC	0.358													12	32					0	0	0	0	C	198272767	C	C	198272767	2	2	228	1	0	0	0	0	0	0	0	1	14214	1683	59	5		5	SF3B1	2	198272767	Silent	SNP	T	TCGA-CV-7178-01A-21D-2012-08	18634031	198272767	44926606	28	41638											
TUBA4A	7277	broad.mit.edu	37	chr2	220116737	220116737	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttcctctcaccaatgacCgtaggctccagatccacaaa	12	8	5	16	1	1	2	1	1	1	1	5	2	4	2	5	1	0	2	5	1	3	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:220116737C>T	uc002vkt.1	-	2	277	c.219G>A	c.(217-219)ACG>ACA	p.T73T	TUBA4A_uc010zkz.1_Silent_p.T58T|TUBA4B_uc002vku.2_5'Flank|TUBA4B_uc002vkv.1_5'Flank	NM_006000	NP_005991	P68366	TBA4A_HUMAN	tubulin, alpha 4a	73					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)	3		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACCAATGACCGTAGGCTCCA	0.527													9	29					0	0	0	0	T	220116737	T	T	220116737	2	4	228	1	0	0	0	0	0	0	0	1	16817	639	23	1		1	TUBA4A	2	220116737	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	21843970	220116737	23082636	29	41639											
INHA	3623	broad.mit.edu	37	chr2	220439871	220439871	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgatgtcctggccttggTctccctctgctctgcgcctg	1	13	10	17	1	3	1	0	1	3	0	5	1	4	1	5	2	2	1	5	2	0	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:220439871T>A	uc002vmk.1	+	2	868	c.724T>A	c.(724-726)TCT>ACT	p.S242T		NM_002191	NP_002182	P05111	INHA_HUMAN	inhibin alpha subunit precursor	242					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CTGGCCTTGGTCTCCCTCTGC	0.657													9	38					0	0	0	0	A	220439871	A	A	220439871	3	1	228	1	0	0	0	0	1	0	0	0	7779	1667	58	5	730	5	INHA	2	220439871	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	323134	220439871	22759502	30	41640											
CHRNG	1146	broad.mit.edu	37	chr2	233406237	233406237	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaactgctcccttatcttCcagtgaggccatttattggg	8	13	9	11	0	1	2	0	1	1	1	3	2	3	2	3	2	2	1	3	2	3	5			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr2:233406237C>A	uc002vsx.1	+	5	525	c.504C>A	c.(502-504)TTC>TTA	p.F168L	CHRNG_uc010fyd.2_Missense_Mutation_p.F168L|CHRNG_uc010fye.1_Intron	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	168	Extracellular (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CCCTTATCTTCCAGTGAGGCC	0.582													35	102					6.05902e-23	1.34134e-22	1	0	A	233406237	A	A	233406237	3	1	228	1	0	0	0	0	1	0	0	0	3411	854	30	2	522	2	CHRNG	2	233406237	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	12966366	233406237	9793136	31	41641											
ATP2B2	491	broad.mit.edu	37	chr3	10417306	10417306	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagagcaccaggatgatcacCgtgatggctgacatcaccaa	13	7	10	11	1	2	4	2	3	0	1	2	5	2	5	3	2	1	2	3	2	2	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr3:10417306C>T	uc003bvt.2	-	11	1663	c.1224G>A	c.(1222-1224)ACG>ACA	p.T408T	ATP2B2_uc003bvv.2_Silent_p.T363T|ATP2B2_uc003bvw.2_Silent_p.T363T|ATP2B2_uc010hdo.2_Silent_p.T113T	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	408	Helical; (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GGATGATCACCGTGATGGCTG	0.557													14	11					0	0	0	0	T	10417306	T	T	10417306	2	4	228	1	0	0	0	0	0	0	0	1	1142	639	23	1		1	ATP2B2	3	10417306	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08		10417306	187605124	32	41642											
ZNF621	285268	broad.mit.edu	37	chr3	40573572	40573572	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttataaagcaggaagcctCtgaagaaacagagttgcaca	17	7	10	7	0	1	3	0	1	1	2	1	4	1	4	1	1	4	4	1	1	6	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr3:40573572C>G	uc003ckm.2	+	5	527	c.311C>G	c.(310-312)TCT>TGT	p.S104C	ZNF621_uc003ckn.2_Missense_Mutation_p.S104C|ZNF621_uc003cko.2_Missense_Mutation_p.S69C|ZNF621_uc011aze.1_Missense_Mutation_p.S96C	NM_001098414	NP_001091884	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		CAGGAAGCCTCTGAAGAAACA	0.423													18	38					0	0	0	0	G	40573572	G	G	40573572	3	3	228	1	0	0	0	0	1	0	0	0	18112	913	32	2	325	2	ZNF621	3	40573572	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	30156266	40573572	157448858	33	41643											
ALG1L2	644974	broad.mit.edu	37	chr3	129813348	129813348	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagggccgaggactaccccCgcttctaggtgagaggccag	8	5	16	12	2	1	1	0	1	1	1	1	5	1	3	4	5	1	1	4	5	2	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr3:129813348C>T	uc011bld.1	+	5	602	c.416C>T	c.(415-417)CCG>CTG	p.P139L	ALG1L2_uc010hth.2_Intron	NM_001136152	NP_001129624	C9J202	AG1L2_HUMAN	asparagine-linked glycosylation 1-like 2	139					biosynthetic process		transferase activity, transferring glycosyl groups				0						GGACTACCCCCGCTTCTAGGT	0.617													6	20					0	0	0	0	T	129813348	T	T	129813348	3	4	228	1	0	0	0	0	1	0	0	0	518	652	23	1	434	1	ALG1L2	3	129813348	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	89239776	129813348	68209082	34	41644											
ABCC5	10057	broad.mit.edu	37	chr3	183681281	183681281	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaaggcactgagggggtcGtccaggatgtagatgctcct	8	10	14	9	1	1	2	0	1	1	1	4	3	3	3	2	4	1	3	2	4	2	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr3:183681281G>A	uc003fmg.2	-	15	2292	c.2127C>T	c.(2125-2127)GAC>GAT	p.D709D	ABCC5_uc011bqt.1_Silent_p.D237D|ABCC5_uc010hxl.2_Silent_p.D709D	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	709	ABC transporter 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGAGGGGGTCGTCCAGGATGT	0.547													21	119					0	0	0	0	A	183681281	A	A	183681281	2	1	228	1	0	0	0	0	0	0	0	1	56	1136	40	1		1	ABCC5	3	183681281	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08	53867933	183681281	14341149	35	41645											
KIAA1530	57654	broad.mit.edu	37	chr4	1379683	1379683	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcggagggtagtggcagcCatgaaccggatggaccagaa	11	5	17	8	2	0	2	0	1	0	1	0	5	0	5	3	5	3	2	3	5	3	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr4:1379683C>T	uc003gde.3	+	14	2511	c.2064C>T	c.(2062-2064)GCC>GCT	p.A688A	KIAA1530_uc010ibv.2_Silent_p.A239A	NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	688											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			TAGTGGCAGCCATGAACCGGA	0.592													45	42					0	0	0	0	T	1379683	T	T	1379683	2	4	228	1	0	0	0	0	0	0	0	1	8280	581	21	4		4	KIAA1530	4	1379683	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08		1379683	189774593	36	41646											
MFSD10	10227	broad.mit.edu	37	chr4	2932838	2932838	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggccagagcacctaggctgCgcagtgtacccatgaccgtg	8	7	13	13	2	0	2	0	1	0	1	0	2	0	2	4	2	3	4	4	2	2	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr4:2932838C>T	uc003gfw.2	-	11	1516	c.1202G>A	c.(1201-1203)CGC>CAC	p.R401H	MFSD10_uc003gfv.2_Missense_Mutation_p.R91H|MFSD10_uc003gfx.2_Missense_Mutation_p.R225H|MFSD10_uc003gfz.2_Missense_Mutation_p.R401H|MFSD10_uc003gfy.2_RNA|MFSD10_uc003gga.2_Missense_Mutation_p.A365T|MFSD10_uc003ggb.1_Missense_Mutation_p.R401H|MFSD10_uc003ggc.2_Missense_Mutation_p.A355T	NM_001120	NP_001111	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing	401					apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		ACCTAGGCTGCGCAGTGTACC	0.706													5	5					0	0	0	0	T	2932838	T	T	2932838	3	4	228	1	0	0	0	0	1	0	0	0	9581	768	27	1	173	1	MFSD10	4	2932838	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	1553155	2932838	188221438	37	41647											
TRAM1L1	133022	broad.mit.edu	37	chr4	118005444	118005444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgcgcttgcaaagattatGaagatttctctttcctcttt	10	17	6	8	1	2	3	0	1	2	2	4	3	3	3	1	0	2	2	1	0	4	5			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr4:118005444G>A	uc003ibv.3	-	1	1293	c.1106C>T	c.(1105-1107)TCA>TTA	p.S369L		NM_152402	NP_689615	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like	369	Cytoplasmic (Potential).				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)	1						CAAAGATTATGAAGATTTCTC	0.378													48	62					0	0	0	0	A	118005444	A	A	118005444	3	1	228	1	0	0	0	0	1	0	0	0	16519	1294	45	2	7	2	TRAM1L1	4	118005444	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	115072606	118005444	73148832	38	41648											
KLKB1	3818	broad.mit.edu	37	chr4	187175918	187175918	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggctcctttgaattacactgGtatgtagcatatgtaagaag	12	13	10	6	0	0	2	0	1	0	1	1	2	1	2	1	2	2	5	1	2	7	6			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr4:187175918G>A	uc003iyy.2	+	12	1560	c.1489_splice	c.e12+1	p.E497_splice	KLKB1_uc011clc.1_Splice_Site_p.E295_splice|KLKB1_uc011cld.1_Splice_Site_p.E459_splice	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor						blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		AATTACACTGGTATGTAGCAT	0.383													8	16					0	0	0	0	A	187175918	A	A	187175918	5	1	228	1	0	0	0	0	0	0	1	0	8451	1275	44	4	1532	4	KLKB1	4	187175918	Splice_Site	SNP	G	TCGA-CV-7178-01A-21D-2012-08	69170474	187175918	3978358	39	41649											
F11	2160	broad.mit.edu	37	chr4	187201215	187201215	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggattgcccagtacacgcAttaaaaagagcaaagctctt	14	9	9	9	1	1	1	0	0	1	1	1	2	1	2	1	1	4	4	1	1	5	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr4:187201215A>T	uc003iza.1	+	8	1138	c.805A>T	c.(805-807)ATT>TTT	p.I269F		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	269	Apple 3.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	CAGTACACGCATTAAAAAGAG	0.398													14	41					0	0	0	0	T	187201215	T	T	187201215	3	4	228	1	0	0	0	0	1	0	0	0	5362	217	8	5	831	5	F11	4	187201215	Missense_Mutation	SNP	A	TCGA-CV-7178-01A-21D-2012-08	25297	187201215	3953061	40	41650											
MYO10	4651	broad.mit.edu	37	chr5	16682098	16682098	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgcagcacccggttggcCgtgatgatcacaaacgagtt	10	8	12	11	3	1	2	1	2	0	0	1	3	1	2	2	2	3	4	2	2	1	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr5:16682098C>T	uc003jft.3	-	31	4539	c.4071G>A	c.(4069-4071)ACG>ACA	p.T1357T	MYO10_uc011cnb.1_5'UTR|MYO10_uc011cnc.1_Silent_p.T236T|MYO10_uc011cnd.1_Silent_p.T714T|MYO10_uc011cne.1_Silent_p.T714T|MYO10_uc010itx.2_Silent_p.T979T	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1357					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CCCGGTTGGCCGTGATGATCA	0.582													26	183					0	0	0	0	T	16682098	T	T	16682098	2	4	228	1	0	0	0	0	0	0	0	1	10115	639	23	1		1	MYO10	5	16682098	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08		16682098	164233162	41	41651											
CDH6	1004	broad.mit.edu	37	chr5	31305351	31305351	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatccttatgttgagccacGatttctctacttggggcctt	7	15	8	11	1	1	1	0	1	1	0	3	2	2	1	3	2	2	1	3	2	3	6			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr5:31305351G>T	uc003jhe.1	+	7	1396	c.1070G>T	c.(1069-1071)CGA>CTA	p.R357L	CDH6_uc003jhd.1_Missense_Mutation_p.R357L	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	357	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						GTTGAGCCACGATTTCTCTAC	0.468													46	61					8.20599e-20	1.80419e-19	1	0	T	31305351	T	T	31305351	3	4	228	1	0	0	0	0	1	0	0	0	3129	1058	37	3	1092	3	CDH6	5	31305351	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	14623253	31305351	149609909	42	41652											
ZNF354A	6940	broad.mit.edu	37	chr5	178140587	178140587	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgaagagtcttgtgtttGcgttgactttgtggttttat	8	19	11	3	1	1	3	0	2	1	1	1	3	1	3	0	1	1	3	0	1	3	6			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr5:178140587G>C	uc003mjj.2	-	5	490	c.292C>G	c.(292-294)CAA>GAA	p.Q98E		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	98					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		TCTTGTGTTTGCGTTGACTTT	0.368													37	47					0	0	0	0	C	178140587	C	C	178140587	3	2	228	1	0	0	0	0	1	0	0	0	17931	1328	46	4	1529	4	ZNF354A	5	178140587	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	146835236	178140587	2774673	43	41653											
ZNF184	7738	broad.mit.edu	37	chr6	27420986	27420986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctggagatagctcttcttCagaaatgtcaggctctgggg	8	12	12	9	0	6	2	2	0	4	2	6	3	6	2	0	4	1	2	0	4	2	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr6:27420986C>T	uc003njj.2	-	5	1163	c.352G>A	c.(352-354)GAA>AAA	p.E118K	ZNF184_uc010jqv.2_Missense_Mutation_p.E118K|ZNF184_uc003nji.2_Missense_Mutation_p.E118K	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	118					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGCTCTTCTTCAGAAATGTCA	0.378													43	43					0	0	0	0	T	27420986	T	T	27420986	3	4	228	1	0	0	0	0	1	0	0	0	17818	835	29	2	1907	2	ZNF184	6	27420986	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08		27420986	143694081	44	41654											
MOG	4340	broad.mit.edu	37	chr6	29633938	29633938	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgcctttcagatcctttctActgggtgagccctggagtgc	5	13	11	12	0	2	2	1	1	1	1	3	3	3	3	3	2	4	0	3	2	1	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr6:29633938A>G	uc003nnf.2	+	3	624	c.446A>G	c.(445-447)TAC>TGC	p.Y149C	MOG_uc003nmy.1_Missense_Mutation_p.Y149C|MOG_uc003nmz.2_3'UTR|MOG_uc011dlt.1_Missense_Mutation_p.Y79C|MOG_uc003nna.2_Missense_Mutation_p.Y33C|MOG_uc011dlu.1_Missense_Mutation_p.Y33C|MOG_uc011dlv.1_Missense_Mutation_p.Y33C|MOG_uc003nnd.2_3'UTR|MOG_uc003nne.2_Missense_Mutation_p.Y149C|MOG_uc003nng.2_Missense_Mutation_p.Y149C|MOG_uc003nnh.2_Missense_Mutation_p.Y149C|MOG_uc003nni.2_Missense_Mutation_p.Y149C|MOG_uc003nnj.2_Missense_Mutation_p.Y149C|MOG_uc003nnk.2_Missense_Mutation_p.Y149C	NM_206809	NP_996532	Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein isoform	149	Extracellular (Potential).				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)	1						gatcctttctactgggTGAGC	0.303													52	57					0	0	0	0	G	29633938	G	G	29633938	3	3	228	1	0	0	0	0	1	0	0	0	9746	391	14	5	540	5	MOG	6	29633938	Missense_Mutation	SNP	A	TCGA-CV-7178-01A-21D-2012-08	2212952	29633938	141481129	45	41655											
HLA-DRA	3122	broad.mit.edu	37	chr6	32410230	32410230	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttcttgcctttcagaagaaCatgtgatcatccaggccgag	10	12	9	10	1	3	3	2	1	1	2	4	4	4	3	3	1	2	0	3	1	2	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr6:32410230C>T	uc003obh.2	+	2	169	c.88C>T	c.(88-90)CAT>TAT	p.H30Y	HLA-DRA_uc003obi.2_Missense_Mutation_p.H30Y	NM_019111	NP_061984	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR	30	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			ovary(1)|skin(1)	2						TTCAGAAGAACATGTGATCAT	0.433									T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Kaposi_Sarcoma_Familial_Clustering_of				51	161					0	0	0	0	T	32410230	T	T	32410230	3	4	228	1	0	0	0	0	1	0	0	0	7246	478	17	4	94	4	HLA-DRA	6	32410230	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	2776292	32410230	138704837	46	41656											
TAP1	6890	broad.mit.edu	37	chr6	32816769	32816769	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggtggagggacctcacctCcacagcctgggtgaactgca	10	6	13	12	0	1	1	1	1	0	0	2	3	2	3	4	4	3	1	4	4	2	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr6:32816769C>T	uc003ocg.2	-	6	1710	c.1555G>A	c.(1555-1557)GAG>AAG	p.E519K	TAP1_uc011dqi.1_Missense_Mutation_p.E258K	NM_000593	NP_000584	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family	519	Involved in peptide-binding site.|Helical; Name=10; (Potential).|ABC transmembrane type-1.				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1						GACCTCACCTCCACAGCCTGG	0.532													12	29					0	0	0	0	T	32816769	T	T	32816769	3	4	228	1	0	0	0	0	1	0	0	0	15616	864	30	2	895	2	TAP1	6	32816769	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	406539	32816769	138298298	47	41657											
C6orf72	116254	broad.mit.edu	37	chr6	149893688	149893688	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggacaggtgtatgtaaatGacttacctgtaaatagtggt	12	13	12	4	0	0	1	0	1	0	0	0	2	0	2	1	3	1	3	1	3	7	5			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr6:149893688G>C	uc003qmq.1	+	3	253	c.226G>C	c.(226-228)GAC>CAC	p.D76H	C6orf72_uc010kie.1_Intron	NM_138785	NP_620140	Q9NU53	CF072_HUMAN	hypothetical protein LOC116254 precursor	76	Extracellular (Potential).					integral to membrane					0		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;9.66e-12)|GBM - Glioblastoma multiforme(68;0.171)		GTATGTAAATGACTTACCTGT	0.308													15	39					0	0	0	0	C	149893688	C	C	149893688	3	2	228	1	0	0	0	0	1	0	0	0	2381	1290	45	2	236	2	C6orf72	6	149893688	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	117076919	149893688	21221379	48	41658											
RSPH3	83861	broad.mit.edu	37	chr6	159401883	159401883	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagaaggtcagccaggtaaCgctgtgcaaatgctcgggcg	10	6	16	9	3	1	1	1	0	0	1	2	2	1	1	1	4	4	4	1	4	3	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr6:159401883C>T	uc003qrx.2	-	6	1398	c.1208G>A	c.(1207-1209)CGT>CAT	p.R403H	RSPH3_uc010kju.2_Missense_Mutation_p.R307H	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	403										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		AGCCAGGTAACGCTGTGCAAA	0.463													12	40					0	0	0	0	T	159401883	T	T	159401883	3	4	228	1	0	0	0	0	1	0	0	0	13770	536	19	1	486	1	RSPH3	6	159401883	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	9508195	159401883	11713184	49	41659											
ANLN	54443	broad.mit.edu	37	chr7	36459871	36459871	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccaaagaactcgtgtccctCgagctgaatctggtgatagc	10	10	10	11	2	1	3	0	2	1	1	5	4	3	3	2	1	3	1	2	1	4	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:36459871C>T	uc003tff.2	+	11	2167	c.1963C>T	c.(1963-1965)CGA>TGA	p.R655*	ANLN_uc011kaz.1_Nonsense_Mutation_p.R567*|ANLN_uc003tfg.2_Nonsense_Mutation_p.R618*|ANLN_uc010kxe.2_Nonsense_Mutation_p.R617*	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	655	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						TCGTGTCCCTCGAGCTGAATC	0.443													20	156					0	0	0	0	T	36459871	T	T	36459871	4	4	228	1	0	0	0	0	0	1	0	0	694	876	31	1	2005	1	ANLN	7	36459871	Nonsense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08		36459871	122678792	50	41660											
SFRP4	6424	broad.mit.edu	37	chr7	37956018	37956018	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcaggtggttgggcatcCgcgtgatgttccagggcatg	5	10	18	8	2	0	1	0	1	0	0	2	1	2	1	2	5	1	5	2	5	0	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:37956018C>A	uc003tfo.3	-	1	508	c.122G>T	c.(121-123)CGG>CTG	p.R41L		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	41	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						GTTGGGCATCCGCGTGATGTT	0.692													5	147					0.000602214	0.00120069	1	0	A	37956018	A	A	37956018	3	1	228	1	0	0	0	0	1	0	0	0	14228	652	23	3	942	3	SFRP4	7	37956018	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	1496147	37956018	121182645	51	41661											
AEBP1	165	broad.mit.edu	37	chr7	44153489	44153489	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcgggcacagatgcggctgCggcgcctcaacgccaccacc	7	5	12	17	5	1	1	1	0	0	1	2	1	1	1	4	3	3	2	4	3	1	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:44153489C>T	uc003tkb.2	+	21	3411	c.3106C>T	c.(3106-3108)CGG>TGG	p.R1036W	AEBP1_uc003tkc.3_Missense_Mutation_p.R611W|AEBP1_uc003tkd.2_Missense_Mutation_p.R286W	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	1036	Required for transcriptional repression (By similarity).|Interaction with MAPK1 and MAPK3 (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GATGCGGCTGCGGCGCCTCAA	0.692													12	38					0	0	0	0	T	44153489	T	T	44153489	3	4	228	1	0	0	0	0	1	0	0	0	349	759	27	1	3188	1	AEBP1	7	44153489	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	6197471	44153489	114985174	52	41662											
ZMIZ2	83637	broad.mit.edu	37	chr7	44797689	44797689	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccactgccccgacagggggtCaagagaacctactctgaggt	10	6	12	13	1	2	2	1	1	1	1	2	4	2	2	4	3	3	0	4	3	3	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:44797689C>G	uc003tlr.2	+	6	918	c.795C>G	c.(793-795)GTC>GTG	p.V265V	ZMIZ2_uc003tlq.2_Silent_p.V233V|ZMIZ2_uc003tls.2_Silent_p.V265V|ZMIZ2_uc003tlt.2_5'Flank|ZMIZ2_uc010kyj.2_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	265	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						GACAGGGGGTCAAGAGAACCT	0.607													14	72					0	0	0	0	G	44797689	G	G	44797689	2	3	228	1	0	0	0	0	0	0	0	1	17764	813	29	2		2	ZMIZ2	7	44797689	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	644200	44797689	114340974	53	41663											
ZNF735	730291	broad.mit.edu	37	chr7	63680527	63680527	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacctttaactgctcctcAactgtaaaggcacataagag	15	9	7	10	0	1	2	1	0	0	2	2	2	2	2	2	1	4	3	2	1	6	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:63680527A>G	uc011kdn.1	+	4	1098	c.1098A>G	c.(1096-1098)TCA>TCG	p.S366S		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	366	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTGCTCCTCAACTGTAAAGG	0.383													4	43					0	0	0	0	G	63680527	G	G	63680527	2	3	228	1	0	0	0	0	0	0	0	1	18191	117	5	5		5	ZNF735	7	63680527	Silent	SNP	A	TCGA-CV-7178-01A-21D-2012-08	18882838	63680527	95458136	54	41664											
AUTS2	26053	broad.mit.edu	37	chr7	70255917	70255917	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tctctcccagaaggacgactCctctgtccgcagagataagg	10	8	10	13	2	2	2	0	0	2	2	6	5	5	3	3	2	0	1	3	2	2	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:70255917C>G	uc003tvw.3	+	19	4458	c.3715C>G	c.(3715-3717)CCT>GCT	p.P1239A	AUTS2_uc003tvx.3_Missense_Mutation_p.P1215A|AUTS2_uc011keg.1_Missense_Mutation_p.P691A	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1239										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		AAGGACGACTCCTCTGTCCGC	0.627													13	36					0	0	0	0	G	70255917	G	G	70255917	3	3	228	1	0	0	0	0	1	0	0	0	1227	855	30	2	3934	2	AUTS2	7	70255917	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	6575390	70255917	88882746	55	41665											
MUC17	140453	broad.mit.edu	37	chr7	100677537	100677537	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctagaacactttcagcaaCtcctgttgacaccagcacac	12	8	7	14	0	1	2	1	1	0	1	2	2	2	2	2	1	4	4	2	1	3	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:100677537C>G	uc003uxp.1	+	3	2893	c.2840C>G	c.(2839-2841)ACT>AGT	p.T947S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	947	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|13.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTTTCAGCAACTCCTGTTGAC	0.507													177	412					0	0	0	0	G	100677537	G	G	100677537	3	3	228	1	0	0	0	0	1	0	0	0	10027	565	20	4	2850	4	MUC17	7	100677537	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	30421620	100677537	58461126	56	41666											
CTTNBP2	83992	broad.mit.edu	37	chr7	117501264	117501264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actcctgtgtcgtccttaccCgcagggcctcgatgacaagg	7	9	11	14	3	0	1	0	1	0	0	4	2	2	1	4	2	1	1	4	2	2	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:117501264C>T	uc003vjf.2	-	2	280	c.188G>A	c.(187-189)CGG>CAG	p.R63Q		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	63										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CGTCCTTACCCGCAGGGCCTC	0.483													7	25					0	0	0	0	T	117501264	T	T	117501264	3	4	228	1	0	0	0	0	1	0	0	0	4062	666	23	1	4891	1	CTTNBP2	7	117501264	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	16823727	117501264	41637399	57	41667											
KCND2	3751	broad.mit.edu	37	chr7	120386013	120386013	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaatgtatcaggaagccaTcaaggtagtatacaagaact	16	8	9	8	0	2	1	2	0	0	1	2	2	2	2	2	2	3	3	2	2	9	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:120386013T>C	uc003vjj.1	+	5	2612	c.1647T>C	c.(1645-1647)CAT>CAC	p.H549H		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	549	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					CAGGAAGCCATCAAGGTAGTA	0.448													15	104					0	0	0	0	C	120386013	C	C	120386013	2	2	228	1	0	0	0	0	0	0	0	1	8058	1432	50	5		5	KCND2	7	120386013	Silent	SNP	T	TCGA-CV-7178-01A-21D-2012-08	2884749	120386013	38752650	58	41668											
FEZF1	389549	broad.mit.edu	37	chr7	121944307	121944307	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agttgagatgcagagagtgcTtgggttcccccttgggtaag	8	11	15	7	0	0	2	0	1	0	2	1	4	1	2	2	2	2	5	2	2	1	5			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:121944307T>C	uc003vkd.2	-	1	259	c.185A>G	c.(184-186)AAG>AGG	p.K62R	FEZF1_uc003vkc.2_Missense_Mutation_p.K62R|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	62					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						CAGAGAGTGCTTGGGTTCCCC	0.627													23	107					0	0	0	0	C	121944307	C	C	121944307	3	2	228	1	0	0	0	0	1	0	0	0	5857	1609	56	5	1258	5	FEZF1	7	121944307	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	1558294	121944307	37194356	59	41669											
PRSS1	5644	broad.mit.edu	37	chr7	142459768	142459768	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgttaatcaagctctcctCacgtgcagtaatcaacgccc	11	10	6	14	2	4	0	3	0	1	0	5	0	4	0	2	0	3	4	2	0	4	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr7:142459768C>G	uc003wak.2	+	3	361	c.344C>G	c.(343-345)TCA>TGA	p.S115*	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Nonsense_Mutation_p.S55*	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	115	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			AAGCTCTCCTCACGTGCAGTA	0.562									Hereditary_Pancreatitis				28	149					0	0	0	0	G	142459768	G	G	142459768	4	3	228	1	0	0	0	0	0	1	0	0	12676	838	29	2	354	2	PRSS1	7	142459768	Nonsense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	20515461	142459768	16678895	60	41670											
LYN	4067	broad.mit.edu	37	chr8	56912010	56912010	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattaagtggacggctccagAagcaatcaactttggatgtt	12	12	10	7	1	1	1	1	0	0	1	2	3	2	3	1	3	2	3	1	3	5	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr8:56912010A>G	uc003xsk.3	+	12	1520	c.1238A>G	c.(1237-1239)GAA>GGA	p.E413G	LYN_uc003xsl.3_Missense_Mutation_p.E392G	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	413	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			ACGGCTCCAGAAGCAATCAAC	0.393													11	88					0	0	0	0	G	56912010	G	G	56912010	3	3	228	1	0	0	0	0	1	0	0	0	9158	246	9	5	1280	5	LYN	8	56912010	Missense_Mutation	SNP	A	TCGA-CV-7178-01A-21D-2012-08		56912010	89452012	61	41671											
CDH17	1015	broad.mit.edu	37	chr8	95182707	95182707	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcattaatatctttaactttTacatgaatttccagcggata	13	17	4	7	1	2	1	1	1	1	0	3	2	3	2	1	1	3	0	1	1	6	8			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr8:95182707T>C	uc003ygh.2	-	9	1109	c.984A>G	c.(982-984)GTA>GTG	p.V328V	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Silent_p.V328V	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	328	Extracellular (Potential).|Cadherin 3.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CTTTAACTTTTACATGAATTT	0.398													22	94					0	0	0	0	C	95182707	C	C	95182707	2	2	228	1	0	0	0	0	0	0	0	1	3117	1741	61	5		5	CDH17	8	95182707	Silent	SNP	T	TCGA-CV-7178-01A-21D-2012-08	38270697	95182707	51181315	62	41672											
TNFRSF11B	4982	broad.mit.edu	37	chr8	119936942	119936942	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catcaagctacgaagctgctCgaaggtgaggttagcatgtc	11	9	12	9	2	1	1	1	1	0	0	3	3	1	1	0	2	5	5	0	2	5	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr8:119936942C>T	uc003yon.3	-	5	1200	c.877G>A	c.(877-879)GAG>AAG	p.E293K		NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	293	Death 2.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			CGAAGCTGCTCGAAGGTGAGG	0.448													16	111					0	0	0	0	T	119936942	T	T	119936942	3	4	228	1	0	0	0	0	1	0	0	0	16351	893	31	1	332	1	TNFRSF11B	8	119936942	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	24754235	119936942	26427080	63	41673											
HAS2	3037	broad.mit.edu	37	chr8	122626402	122626402	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcttccgcctgccacactTattgatgagaactacataca	11	12	5	13	1	1	2	0	2	1	1	2	3	2	2	3	0	4	0	3	0	4	6			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr8:122626402T>C	uc003yph.2	-	4	2144	c.1606A>G	c.(1606-1608)AAG>GAG	p.K536E		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	536	Extracellular (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			CTGCCACACTTATTGATGAGA	0.423													62	100					0	0	0	0	C	122626402	C	C	122626402	3	2	228	1	0	0	0	0	1	0	0	0	7001	1763	61	5	56	5	HAS2	8	122626402	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	2689460	122626402	23737620	64	41674											
C8orf76	84933	broad.mit.edu	37	chr8	124250097	124250097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caggtgagccagacaccgagCctgaccttcctggacatccc	9	6	10	16	1	0	3	0	2	0	1	2	5	2	4	6	2	2	0	6	2	0	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr8:124250097C>T	uc003yqc.1	-	3	329	c.298G>A	c.(298-300)GCT>ACT	p.A100T	C8orf76_uc003yqd.2_Missense_Mutation_p.A68T	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	100							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			AGACACCGAGCCTGACCTTCC	0.428													40	36					0	0	0	0	T	124250097	T	T	124250097	3	4	228	1	0	0	0	0	1	0	0	0	2449	739	26	4	860	4	C8orf76	8	124250097	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	1623695	124250097	22113925	65	41675											
ATAD2	29028	broad.mit.edu	37	chr8	124348766	124348766	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttattacagtgacataatCaggaacctaaaattcaagca	17	11	5	8	0	2	1	2	1	0	0	2	2	2	2	1	1	3	1	1	1	7	6			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr8:124348766C>G	uc003yqh.3	-	22	3166	c.3058G>C	c.(3058-3060)GAT>CAT	p.D1020H	ATAD2_uc011lii.1_Missense_Mutation_p.D811H|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1020	Bromo.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GTGACATAATCAGGAACCTAA	0.328													16	158					0	0	0	0	G	124348766	G	G	124348766	3	3	228	1	0	0	0	0	1	0	0	0	1073	826	29	2	1142	2	ATAD2	8	124348766	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	98669	124348766	22015256	66	41676											
ARHGAP39	80728	broad.mit.edu	37	chr8	145770919	145770919	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctggatcagcttgaagagCtcgcaggcctccttcttcac	8	11	9	13	1	4	2	2	1	2	1	6	3	5	3	2	2	2	3	2	2	1	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr8:145770919C>T	uc003zdt.1	-	7	2790	c.2235G>A	c.(2233-2235)GAG>GAA	p.E745E	ARHGAP39_uc011llk.1_Silent_p.E745E|ARHGAP39_uc003zds.1_Silent_p.E745E	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	745	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						GCTTGAAGAGCTCGCAGGCCT	0.632													31	51					0	0	0	0	T	145770919	T	T	145770919	2	4	228	1	0	0	0	0	0	0	0	1	884	796	28	4		4	ARHGAP39	8	145770919	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	21422153	145770919	593103	67	41677											
CDKN2A	1029	broad.mit.edu	37	chr9	21971132	21971133	+	Frame_Shift_Ins	INS	-	G	G																															acgggtcgggtgagagtggcINSggggtcggcgcagttgggct																										TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr9:21971132_21971133insG	uc003zpk.2	-	2	437_438	c.225_226insC	c.(223-228)CCCGCCfs	p.P75fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Frame_Shift_Ins_p.R131fs	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	75_76					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.P75L(2)|p.A76fs*70(2)|p.P75H(1)|p.E61_L94del(1)|p.A76fs*64(1)|p.L65fs*38(1)|p.A68fs*3(1)|p.P75fs*71(1)|p.A76T(1)|p.P75S(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GTGAGAGTGGCGGGGTCGGCGC	0.708		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---								G	21971133	G	G	21971132	7	5	228	1	0	1	1	0	0	0	0	0	3176	768	27	0	252	0	CDKN2A	9	21971132	Frame_Shift_Ins	INS	-	TCGA-CV-7178-01A-21D-2012-08		21971132	119242299	68	41678											
FBXO10	26267	broad.mit.edu	37	chr9	37521758	37521758	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaatactgccactccatacaGgccattgtagctgacgtggt	11	10	9	11	1	0	1	0	1	0	0	1	1	1	1	3	2	4	2	3	2	4	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr9:37521758G>A	uc004aab.2	-	8	2057	c.2008C>T	c.(2008-2010)CTG>TTG	p.L670L	FBXO10_uc004aac.2_Silent_p.L686L|FBXO10_uc004aad.2_Silent_p.L220L	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	670	PbH1 12.					ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		ACTCCATACAGGCCATTGTAG	0.572													13	18					0	0	0	0	A	37521758	A	A	37521758	2	1	228	1	0	0	0	0	0	0	0	1	5758	991	35	4		4	FBXO10	9	37521758	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08	15550626	37521758	103691673	69	41679											
ASTN2	23245	broad.mit.edu	37	chr9	120176823	120176823	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccaggtcgtcctgcaccgCgatgcgccccggcagctcgt	4	7	13	17	6	0	0	0	0	0	0	4	1	2	0	5	2	3	3	5	2	0	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr9:120176823C>T	uc004bjs.1	-	1	495	c.394G>A	c.(394-396)GCG>ACG	p.A132T	ASTN2_uc004bjr.1_Missense_Mutation_p.A132T|ASTN2_uc004bjt.1_Missense_Mutation_p.A132T	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	132	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TCCTGCACCGCGATGCGCCCC	0.716													13	35					0	0	0	0	T	120176823	T	T	120176823	3	4	228	1	0	0	0	0	1	0	0	0	1067	768	27	1	3792	1	ASTN2	9	120176823	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	82655065	120176823	21036608	70	41680											
ZBTB43	23099	broad.mit.edu	37	chr9	129595076	129595076	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggacgtctagtaatgccCgctccagaaattgttagtta	12	11	9	9	2	1	1	0	0	1	1	2	2	2	2	2	1	1	4	2	1	5	5			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr9:129595076C>T	uc004bql.2	+	3	561	c.288C>T	c.(286-288)CCC>CCT	p.P96P	ZBTB43_uc010mxf.2_Silent_p.P96P	NM_014007	NP_054726	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	96	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAGTAATGCCCGCTCCAGAAA	0.443													18	44					0	0	0	0	T	129595076	T	T	129595076	2	4	228	1	0	0	0	0	0	0	0	1	17611	639	23	1		1	ZBTB43	9	129595076	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	9418253	129595076	11618355	71	41681											
SETX	23064	broad.mit.edu	37	chr9	135221775	135221775	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccattattgtctactatataTaactcatcatcatctccaat	13	16	1	11	0	5	0	3	0	2	0	6	0	5	0	2	0	2	0	2	0	7	7			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr9:135221775T>A	uc004cbk.2	-	4	444	c.261A>T	c.(259-261)TTA>TTT	p.L87F		NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	87					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CTACTATATATAACTCATCAT	0.338													8	23					0	0	0	0	A	135221775	A	A	135221775	3	1	228	1	0	0	0	0	1	0	0	0	14206	1403	49	5	7864	5	SETX	9	135221775	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	5626699	135221775	5991656	72	41682											
GPR158	57512	broad.mit.edu	37	chr10	25887168	25887168	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgaggctgagtccacggaGtcggtgccgttggtgtgcaa	7	8	17	9	4	0	1	0	1	0	0	2	3	1	2	2	4	3	3	2	4	1	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr10:25887168G>T	uc001isj.2	+	11	2673	c.2613G>T	c.(2611-2613)GAG>GAT	p.E871D	GPR158_uc001isk.2_Missense_Mutation_p.E246D	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	871	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AGTCCACGGAGTCGGTGCCGT	0.498													28	78					5.61819e-17	1.22683e-16	1	0	T	25887168	T	T	25887168	3	4	228	1	0	0	0	0	1	0	0	0	6701	1020	36	4	2655	4	GPR158	10	25887168	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08		25887168	109647579	73	41683											
DNA2	1763	broad.mit.edu	37	chr10	70225525	70225525	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctttttgaaacacctcatgGagaaccgtaccaattagcat	13	11	7	10	1	1	2	1	1	0	1	1	3	1	2	3	1	4	3	3	1	5	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr10:70225525G>A	uc001jof.2	-	4	744	c.744C>T	c.(742-744)CTC>CTT	p.L248L	DNA2_uc001jog.1_Silent_p.L162L|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	162					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						ACACCTCATGGAGAACCGTAC	0.358													6	25					0	0	0	0	A	70225525	A	A	70225525	2	1	228	1	0	0	0	0	0	0	0	1	4618	1161	41	2		2	DNA2	10	70225525	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08	44338357	70225525	65309222	74	41684											
PKD2L1	9033	broad.mit.edu	37	chr10	102048805	102048805	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcgggtgcttccaaatagcTtgttccttctgttggaagaa	8	14	11	8	1	1	1	0	0	1	1	3	2	3	2	2	2	3	4	2	2	4	6			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr10:102048805T>A	uc001kqx.1	-	15	2642	c.2259A>T	c.(2257-2259)CAA>CAT	p.Q753H	BLOC1S2_uc001kqv.1_5'Flank|BLOC1S2_uc001kqw.1_5'Flank|PKD2L1_uc009xwm.1_Missense_Mutation_p.Q706H	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	753	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TCCAAATAGCTTGTTCCTTCT	0.502													27	31					0	0	0	0	A	102048805	A	A	102048805	3	1	228	1	0	0	0	0	1	0	0	0	12022	1606	56	5	166	5	PKD2L1	10	102048805	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	31823280	102048805	33485942	75	41685											
TDRD1	56165	broad.mit.edu	37	chr10	115985910	115985910	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaaaccctgcctctttgcaGagtgcaaccaatcacctcta	11	10	6	14	0	3	2	1	1	2	1	3	2	3	2	4	0	5	2	4	0	4	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr10:115985910G>A	uc001lbg.1	+	22	3263	c.3110G>A	c.(3109-3111)AGA>AAA	p.R1037K	TDRD1_uc001lbf.2_Missense_Mutation_p.R914K|TDRD1_uc001lbh.1_Missense_Mutation_p.R1024K|TDRD1_uc001lbi.1_Missense_Mutation_p.R1028K|TDRD1_uc010qsc.1_Missense_Mutation_p.R641K|TDRD1_uc001lbj.2_Missense_Mutation_p.R746K	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	1037	Tudor 4.				DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		CCTCTTTGCAGAGTGCAACCA	0.438													13	44					0	0	0	0	A	115985910	A	A	115985910	3	1	228	1	0	0	0	0	1	0	0	0	15796	942	33	2	3192	2	TDRD1	10	115985910	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	13937105	115985910	19548837	76	41686											
OR51A4	401666	broad.mit.edu	37	chr11	4967807	4967807	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagtaggaatgggataatTggtttttcttgcaatatctc	11	15	10	5	0	2	0	0	0	2	0	3	3	2	2	0	3	1	3	0	3	5	7			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr11:4967807T>C	uc010qys.1	-	1	524	c.524A>G	c.(523-525)CAA>CGA	p.Q175R		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGGGATAATTGGTTTTTCTT	0.413													48	73					0	0	0	0	C	4967807	C	C	4967807	3	2	228	1	0	0	0	0	1	0	0	0	11141	1812	63	5	419	5	OR51A4	11	4967807	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08		4967807	130038709	77	41687											
ST5	6764	broad.mit.edu	37	chr11	8752059	8752059	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgggctcactccggcccaGccgtttctccagccggtaga	5	8	12	16	3	2	1	1	0	1	1	4	1	3	1	5	3	2	4	5	3	1	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	ead25229-da3f-49c0-9e0d-f76fcac9d337	g.chr11:8752059G>T	uc001mgt.2	-	3	964	c.778C>A	c.(778-780)CTG>ATG	p.L260M	ST5_uc009yfr.2_Intron|ST5_uc001mgu.2_Intron|ST5_uc001mgv.2_Missense_Mutation_p.L260M|ST5_uc010rbq.1_Intron|ST5_uc001mgw.1_Missense_Mutation_p.L260M	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	260					positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CTCCGGCCCAGCCGTTTCTCC	0.612													9	94					9.31168e-06	1.73453e-05	1	0	T	8752059	T	T	8752059	3	4	228	1	0	0	0	0	1	0	0	0	15286	962	34	4	2707	4	ST5	11	8752059	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	3784252	8752059	126254457	78	41688											
NRIP3	56675	broad.mit.edu	37	chr11	9009124	9009124	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccacacaggccaaagagatGagattatataggcagcctgt	14	8	10	9	0	0	2	0	1	0	2	1	4	1	2	3	2	1	1	3	2	4	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr11:9009124G>A	uc001mhg.2	-	3	507	c.393C>T	c.(391-393)CTC>CTT	p.L131L	NRIP3_uc010rbu.1_Silent_p.L131L	NM_020645	NP_065696	Q9NQ35	NRIP3_HUMAN	nuclear receptor interacting protein 3	131					proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)		CCAAAGAGATGAGATTATATA	0.453													18	82					0	0	0	0	A	9009124	A	A	9009124	2	1	228	1	0	0	0	0	0	0	0	1	10708	1277	45	2		2	NRIP3	11	9009124	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08	257065	9009124	125997392	79	41689											
TRMT112	51504	broad.mit.edu	37	chr11	64084793	64084793	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttaggtatcatacgcgccacGaagttggggttgaattccac	10	11	11	9	3	1	1	1	1	0	0	2	2	2	1	2	3	1	3	2	3	5	6			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr11:64084793G>A	uc001nzt.2	-	2	158	c.123C>T	c.(121-123)TTC>TTT	p.F41F	PRDX5_uc001nzu.2_5'Flank|PRDX5_uc001nzv.2_5'Flank|PRDX5_uc001nzw.2_5'Flank|PRDX5_uc001nzx.2_5'Flank	NM_016404	NP_057488	Q9UI30	TR112_HUMAN	tRNA methyltransferase 11-2 homolog	41	TRM112.				peptidyl-glutamine methylation	protein complex	protein binding|protein methyltransferase activity				0						TACGCGCCACGAAGTTGGGGT	0.632													35	44					0	0	0	0	A	64084793	A	A	64084793	2	1	228	1	0	0	0	0	0	0	0	1	16630	1049	37	1		1	TRMT112	11	64084793	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08	55075669	64084793	70921723	80	41690											
P2RY2	5029	broad.mit.edu	37	chr11	72946234	72946234	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcctgcgcagatccgacagaActgacatgcagaggatagaa	14	5	12	10	2	0	5	0	1	0	4	1	7	1	6	2	1	3	2	2	1	3	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr11:72946234A>G	uc001otj.2	+	3	1363	c.1030A>G	c.(1030-1032)ACT>GCT	p.T344A	P2RY2_uc001otk.2_Missense_Mutation_p.T344A|P2RY2_uc001otl.2_Missense_Mutation_p.T344A	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	344	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	ATCCGACAGAACTGACATGCA	0.632													18	153					0	0	0	0	G	72946234	G	G	72946234	3	3	228	1	0	0	0	0	1	0	0	0	11406	43	2	5	1032	5	P2RY2	11	72946234	Missense_Mutation	SNP	A	TCGA-CV-7178-01A-21D-2012-08	8861441	72946234	62060282	81	41691											
ZC3H12C	85463	broad.mit.edu	37	chr11	110035195	110035195	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agccaaaactgcaaacgaagGaggactggtgaaaagcaaca	19	3	11	8	1	0	1	0	1	0	0	0	4	0	3	1	3	6	2	1	3	7	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr11:110035195G>A	uc009yxw.2	+	6	1436	c.1385G>A	c.(1384-1386)GGA>GAA	p.G462E	ZC3H12C_uc010rwc.1_Missense_Mutation_p.G463E|ZC3H12C_uc010rwd.1_Missense_Mutation_p.G463E|ZC3H12C_uc001pkr.3_Missense_Mutation_p.G431E	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	462							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		GCAAACGAAGGAGGACTGGTG	0.493													25	30					0	0	0	0	A	110035195	A	A	110035195	3	1	228	1	0	0	0	0	1	0	0	0	17630	1174	41	2	1407	2	ZC3H12C	11	110035195	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	37088961	110035195	24971321	82	41692											
KCNJ5	3762	broad.mit.edu	37	chr11	128781799	128781799	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaacgcagtcatctccatgCgggacgagaagctgtgcctc	10	7	11	13	3	2	1	1	0	1	1	4	3	2	2	2	1	4	2	2	1	2	0	rs143790141		TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr11:128781799C>T	uc001qet.2	+	2	945	c.631C>T	c.(631-633)CGG>TGG	p.R211W	KCNJ5_uc009zck.2_Missense_Mutation_p.R211W|KCNJ5_uc001qew.2_Missense_Mutation_p.R211W	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	211	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CATCTCCATGCGGGACGAGAA	0.587													18	65					0	0	0	0	T	128781799	T	T	128781799	3	4	228	1	0	0	0	0	1	0	0	0	8093	759	27	1	633	1	KCNJ5	11	128781799	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	18746604	128781799	6224717	83	41693											
APLP2	334	broad.mit.edu	37	chr11	129979472	129979472	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgctttgaaacaaaagAagaagttcttcagtactgtc	14	11	9	7	0	2	3	1	1	1	2	3	4	2	3	0	0	4	4	0	0	6	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr11:129979472A>T	uc010sby.1	+	2	411	c.254A>T	c.(253-255)GAA>GTA	p.E85V	APLP2_uc001qfp.2_Missense_Mutation_p.E85V|APLP2_uc001qfq.2_Missense_Mutation_p.E85V|APLP2_uc010sbz.1_Intron|APLP2_uc001qfr.2_Intron|APLP2_uc001qfs.2_Missense_Mutation_p.E85V|APLP2_uc001qfv.2_Missense_Mutation_p.E32V	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	85	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		GAAACAAAAGAAGAAGTTCTT	0.403													14	21					0	0	0	0	T	129979472	T	T	129979472	3	4	228	1	0	0	0	0	1	0	0	0	779	246	9	5	260	5	APLP2	11	129979472	Missense_Mutation	SNP	A	TCGA-CV-7178-01A-21D-2012-08	1197673	129979472	5027044	84	41694											
CACNA2D4	93589	broad.mit.edu	37	chr12	2027520	2027520	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaaggcccaggccacgggCattggctggaggggaatcca	11	4	15	11	1	0	0	0	0	0	0	1	2	1	2	3	7	0	2	3	7	2	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr12:2027520C>A	uc001qjp.2	-	1	351	c.120G>T	c.(118-120)ATG>ATT	p.M40I	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.M40I	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	40	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AGGCCACGGGCATTGGCTGGA	0.657													8	14					5.18039e-06	1.07284e-05	1	0	A	2027520	A	A	2027520	3	1	228	1	0	0	0	0	1	0	0	0	2563	710	25	4	3445	4	CACNA2D4	12	2027520	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08		2027520	131824375	85	41695											
LRRK2	120892	broad.mit.edu	37	chr12	40646775	40646775	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcttcatcaaaggaagttttCcaggcatctgcgaatgcatt	11	13	8	9	1	4	0	2	0	2	0	5	2	5	1	1	2	2	3	1	2	3	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr12:40646775C>T	uc001rmg.3	+	11	1366	c.1245C>T	c.(1243-1245)TTC>TTT	p.F415F	LRRK2_uc001rmh.1_Silent_p.F37F	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	415					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGGAAGTTTTCCAGGCATCTG	0.363													13	28					0	0	0	0	T	40646775	T	T	40646775	2	4	228	1	0	0	0	0	0	0	0	1	9083	854	30	2		2	LRRK2	12	40646775	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	38619255	40646775	93205120	86	41696											
MLL2	8085	broad.mit.edu	37	chr12	49423208	49423208	+	Frame_Shift_Del	DEL	G	-	-																															catcctcagtctgattgtgaGggggtgtaggcaaggcagcc																										TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr12:49423208delG	uc001rta.3	-	43	14051	c.14051delC	c.(14050-14052)CCTfs	p.P4684fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4684					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTGATTGTGAGGGGGTGTAGG	0.562			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								-	49423208	-	-	49423208	7	5	228	1	0	1	0	1	0	0	0	0	9674	1000	35	0	2610	0	MLL2	12	49423208	Frame_Shift_Del	DEL	G	TCGA-CV-7178-01A-21D-2012-08	8776433	49423208	84428687	87	41697											
APAF1	317	broad.mit.edu	37	chr12	99060002	99060002	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggacatggaaactgaagAagttgaagacatactgcagg	15	7	13	6	0	0	4	0	2	0	2	0	6	0	6	0	3	3	2	0	3	5	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr12:99060002A>T	uc001tfz.2	+	9	1806	c.1229A>T	c.(1228-1230)GAA>GTA	p.E410V	APAF1_uc001tfy.2_Missense_Mutation_p.E399V|APAF1_uc001tga.2_Missense_Mutation_p.E399V|APAF1_uc001tgb.2_Missense_Mutation_p.E410V|APAF1_uc001tgc.2_Intron	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	410	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	GAAACTGAAGAAGTTGAAGAC	0.348													19	68					0	0	0	0	T	99060002	T	T	99060002	3	4	228	1	0	0	0	0	1	0	0	0	755	246	9	5	1259	5	APAF1	12	99060002	Missense_Mutation	SNP	A	TCGA-CV-7178-01A-21D-2012-08	49636794	99060002	34791893	88	41698											
FLT1	2321	broad.mit.edu	37	chr13	28959102	28959102	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattagcatgacagtctaaaGtggtggaactgctgatggcc	11	10	12	8	0	1	2	0	2	1	0	1	3	1	3	1	3	3	2	1	3	4	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr13:28959102G>T	uc001usb.3	-	14	2321	c.2036C>A	c.(2035-2037)ACT>AAT	p.T679N	FLT1_uc010aar.1_Missense_Mutation_p.T679N	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	679	Ig-like C2-type 7.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	ACAGTCTAAAGTGGTGGAACT	0.448													21	82					2.27731e-05	4.68599e-05	1	0	T	28959102	T	T	28959102	3	4	228	1	0	0	0	0	1	0	0	0	5973	1029	36	4	2138	4	FLT1	13	28959102	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08		28959102	86210776	89	41699											
SLITRK5	26050	broad.mit.edu	37	chr13	88327768	88327768	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgtgtgcagaaaccatcgAttattatggggaaatctgtg	11	13	11	6	2	1	1	0	0	1	1	3	3	1	2	1	2	2	1	1	2	4	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr13:88327768A>T	uc001vln.2	+	2	344	c.125A>T	c.(124-126)GAT>GTT	p.D42V	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	42	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GAAACCATCGATTATTATGGG	0.453													23	133					0	0	0	0	T	88327768	T	T	88327768	3	4	228	1	0	0	0	0	1	0	0	0	14810	333	12	5	127	5	SLITRK5	13	88327768	Missense_Mutation	SNP	A	TCGA-CV-7178-01A-21D-2012-08	59368666	88327768	26842110	90	41700											
OR4M1	441670	broad.mit.edu	37	chr14	20248700	20248700	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccctccttgatatttggtaCtcttccattacagcccctaa	8	14	5	14	0	1	1	0	1	1	0	3	1	3	1	5	1	3	1	5	1	4	7			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr14:20248700C>G	uc010tku.1	+	1	219	c.219C>G	c.(217-219)TAC>TAG	p.Y73*		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATATTTGGTACTCTTCCATTA	0.423													111	356					0	0	0	0	G	20248700	G	G	20248700	4	3	228	1	0	0	0	0	0	1	0	0	11129	576	20	4	221	4	OR4M1	14	20248700	Nonsense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08		20248700	87100840	91	41701											
DHRS4	10901	broad.mit.edu	37	chr14	24438079	24438079	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaaccccgtcccgcctctGaggaccgggagacagcccac	9	3	12	17	3	1	2	0	1	1	1	2	5	2	4	6	3	2	0	6	3	1	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr14:24438079G>C	uc001wla.2	+	8	869	c.836G>C	c.(835-837)TGA>TCA	p.*279S	DHRS4_uc001wlb.2_Nonstop_Mutation_p.*245S|DHRS4_uc010akz.2_Nonstop_Mutation_p.*200S|DHRS4_uc001wlc.3_Intron|DHRS4L2_uc001wld.3_Intron|DHRS4L2_uc001wle.3_Intron|uc001wlf.2_5'Flank|DHRS4L2_uc001wlg.3_5'Flank|DHRS4L2_uc001wlh.3_5'Flank	NM_021004	NP_066284	Q9BTZ2	DHRS4_HUMAN	peroxisomal short-chain alcohol dehydrogenase	279						mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	TCCCGCCTCTGAGGACCGGGA	0.597													8	19					0	0	0	0	C	24438079	C	C	24438079	4	2	228	1	0	0	0	0	0	0	0	0	4514	1285	45	2	866	2	DHRS4	14	24438079	Nonstop_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	4189379	24438079	82911461	92	41702											
C14orf106	55320	broad.mit.edu	37	chr14	45679706	45679706	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggcagaatatcatcatcaTcttcactgtcctggaaactt	11	14	6	10	0	5	1	4	0	1	1	6	2	6	2	1	2	1	1	1	2	3	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr14:45679706T>A	uc001wwf.2	-	14	3488	c.3029A>T	c.(3028-3030)GAT>GTT	p.D1010V		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	1010	Poly-Asp.				cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						ATCATCATCATCTTCACTGTC	0.363													29	62					0	0	0	0	A	45679706	A	A	45679706	3	1	228	1	0	0	0	0	1	0	0	0	1744	1435	50	5	385	5	C14orf106	14	45679706	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	21241627	45679706	61669834	93	41703											
SIPA1L1	26037	broad.mit.edu	37	chr14	72191487	72191487	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacctccaagtccaccattGaagaagatctaaagaaacta	18	7	5	11	0	1	4	0	1	1	3	3	4	3	4	4	0	2	0	4	0	8	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr14:72191487G>A	uc001xms.2	+	17	4960	c.4612G>A	c.(4612-4614)GAA>AAA	p.E1538K	SIPA1L1_uc001xmt.2_Missense_Mutation_p.E1517K|SIPA1L1_uc001xmu.2_Missense_Mutation_p.E1517K|SIPA1L1_uc001xmv.2_Missense_Mutation_p.E1538K|SIPA1L1_uc010ttm.1_Missense_Mutation_p.E992K|SIPA1L1_uc001xmw.2_Missense_Mutation_p.E303K	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1538					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GTCCACCATTGAAGAAGATCT	0.478													13	57					0	0	0	0	A	72191487	A	A	72191487	3	1	228	1	0	0	0	0	1	0	0	0	14394	1291	45	2	4674	2	SIPA1L1	14	72191487	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	26511781	72191487	35158053	94	41704											
ESRRB	2103	broad.mit.edu	37	chr14	76948418	76948418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaagcgacggctggactcaGagagcagcccatacctgagc	12	4	12	13	2	1	2	1	1	0	1	1	5	1	3	2	2	5	2	2	2	2	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr14:76948418G>A	uc001xsq.1	+	4	641	c.574G>A	c.(574-576)GAG>AAG	p.E192K	ESRRB_uc001xsr.2_Missense_Mutation_p.E192K|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	192						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		GCTGGACTCAGAGAGCAGCCC	0.527													5	59					0	0	0	0	A	76948418	A	A	76948418	3	1	228	1	0	0	0	0	1	0	0	0	5285	943	33	2	584	2	ESRRB	14	76948418	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	4756931	76948418	30401122	95	41705											
EIF2AK4	440275	broad.mit.edu	37	chr15	40268785	40268785	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcggcacgagcggccggcGggaccggggacgccgccccc	5	0	19	17	8	0	0	0	0	0	0	0	4	0	2	5	6	2	1	5	6	0	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr15:40268785G>A	uc001zkm.1	+	12	2039	c.1989G>A	c.(1987-1989)GCG>GCA	p.A663A	EIF2AK4_uc010bbj.1_Silent_p.A392A	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	663	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AGCGGCCGGCGGGACCGGGGA	0.692													8	29					0	0	0	0	A	40268785	A	A	40268785	2	1	228	1	0	0	0	0	0	0	0	1	5021	1103	39	1		1	EIF2AK4	15	40268785	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08		40268785	62262607	96	41706											
PLCB2	5330	broad.mit.edu	37	chr15	40581116	40581116	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctgccagcgcctccttctGgaactgtggagacagcaagg	8	8	12	13	1	2	1	0	0	2	1	3	3	3	2	3	3	4	1	3	3	2	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr15:40581116G>A	uc001zld.2	-	32	3659	c.3358C>T	c.(3358-3360)CAG>TAG	p.Q1120*	PLCB2_uc001zlc.2_Nonsense_Mutation_p.Q104*|PLCB2_uc010bbo.2_Nonsense_Mutation_p.Q1116*|PLCB2_uc010ucm.1_Nonsense_Mutation_p.Q1105*	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	1120	Potential.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GCCTCCTTCTGGAACTGTGGA	0.632													5	58					0	0	0	0	A	40581116	A	A	40581116	4	1	228	1	0	0	0	0	0	1	0	0	12083	1357	47	4	203	4	PLCB2	15	40581116	Nonsense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	312331	40581116	61950276	97	41707											
SLC12A1	6557	broad.mit.edu	37	chr15	48500135	48500135	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggagtgctatgacaatttCctccaaagtggagaaactgc	13	9	10	9	0	0	2	0	1	0	1	2	4	2	3	2	2	3	1	2	2	4	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr15:48500135C>A	uc001zwn.3	+	2	435	c.219C>A	c.(217-219)TTC>TTA	p.F73L	SLC12A1_uc010uew.1_Intron|SLC12A1_uc010bem.2_Missense_Mutation_p.F73L|SLC12A1_uc010uex.1_Missense_Mutation_p.F73L	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	73	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	ATGACAATTTCCTCCAAAGTG	0.428													13	58					2.61681e-11	5.67566e-11	1	0	A	48500135	A	A	48500135	3	1	228	1	0	0	0	0	1	0	0	0	14447	854	30	2	221	2	SLC12A1	15	48500135	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	7919019	48500135	54031257	98	41708											
PRTG	283659	broad.mit.edu	37	chr15	55931883	55931883	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcattctgcaggccaacagGattacagcggatggtgtagt	11	9	13	8	1	1	0	0	0	1	0	1	2	1	2	1	4	5	3	1	4	3	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr15:55931883G>T	uc002adg.2	-	13	2329	c.2281C>A	c.(2281-2283)CCT>ACT	p.P761T		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	761	Fibronectin type-III 4.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		AGGCCAACAGGATTACAGCGG	0.478													16	82					3.32936e-07	7.03108e-07	1	0	T	55931883	T	T	55931883	3	4	228	1	0	0	0	0	1	0	0	0	12700	1174	41	2	1203	2	PRTG	15	55931883	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	7431748	55931883	46599509	99	41709											
SLTM	79811	broad.mit.edu	37	chr15	59185178	59185178	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttccttcatcttttcaaaagGcaagatctctttccttctgt	8	18	4	11	0	5	1	2	0	3	1	8	1	7	1	2	1	0	1	2	1	3	6			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr15:59185178G>A	uc002afp.2	-	14	1904	c.1816C>T	c.(1816-1818)CCT>TCT	p.P606S	SLTM_uc002afn.2_Missense_Mutation_p.P148S|SLTM_uc002afo.2_Missense_Mutation_p.P588S|SLTM_uc002afq.2_Missense_Mutation_p.P175S|SLTM_uc010bgd.2_Missense_Mutation_p.P175S	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	606	Arg/Glu-rich.			P -> S (in Ref. 3; AAH14944).	apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TTTTCAAAAGGCAAGATCTCT	0.368													12	38					0	0	0	0	A	59185178	A	A	59185178	3	1	228	1	0	0	0	0	1	0	0	0	14818	1203	42	4	1320	4	SLTM	15	59185178	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	3253295	59185178	43346214	100	41710											
LARP6	55323	broad.mit.edu	37	chr15	71124564	71124564	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctcggcttggcgacgccTccggacccaggggctgccag	5	6	14	16	4	1	0	0	0	1	0	3	2	2	1	4	5	1	2	4	5	0	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr15:71124564T>A	uc002ass.2	-	3	1374	c.1303A>T	c.(1303-1305)AGG>TGG	p.R435W		NM_018357	NP_060827	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	435					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0						TGGCGACGCCTCCGGACCCAG	0.612													44	80					0	0	0	0	A	71124564	A	A	71124564	3	1	228	1	0	0	0	0	1	0	0	0	8672	1550	54	5	176	5	LARP6	15	71124564	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	11939386	71124564	31406828	101	41711											
ISLR	3671	broad.mit.edu	37	chr15	74467616	74467616	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgaccttcatcccccgCgacgccttccgcagcctccg	5	7	9	20	5	1	1	1	1	0	0	4	3	4	1	7	0	2	2	7	0	0	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr15:74467616C>T	uc002axg.1	+	2	699	c.417C>T	c.(415-417)CGC>CGT	p.R139R	ISLR_uc002axh.1_Silent_p.R139R	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	139	LRR 4.				cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TCATCCCCCGCGACGCCTTCC	0.612													18	63					0	0	0	0	T	74467616	T	T	74467616	2	4	228	1	0	0	0	0	0	0	0	1	7897	755	27	1		1	ISLR	15	74467616	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	3343052	74467616	28063776	102	41712											
SPATA8	145946	broad.mit.edu	37	chr15	97327425	97327425	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaagccatgacatgtccctgCggctggaggcctttcaaggg	8	8	14	11	1	1	1	1	1	0	0	2	3	2	2	3	4	2	1	3	4	2	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr15:97327425C>T	uc002bue.2	+	2	342	c.132C>T	c.(130-132)TGC>TGT	p.C44C	uc010urp.1_5'Flank|uc002bud.1_5'Flank	NM_173499	NP_775770	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	44										ovary(1)|skin(1)	2	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			CATGTCCCTGCGGCTGGAGGC	0.587													17	96					0	0	0	0	T	97327425	T	T	97327425	2	4	228	1	0	0	0	0	0	0	0	1	15081	776	27	1		1	SPATA8	15	97327425	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	22859809	97327425	5203967	103	41713											
SOX8	30812	broad.mit.edu	37	chr16	1033825	1033825	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgactacaagtaccagccaCggcgcaggaagagcgccaaa	14	2	11	14	4	0	1	0	0	0	1	0	3	0	2	4	2	4	2	4	2	5	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr16:1033825C>T	uc002ckn.2	+	2	635	c.520C>T	c.(520-522)CGG>TGG	p.R174W	LMF1_uc002ckk.2_5'Flank|uc002ckm.1_5'Flank	NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	174					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				GTACCAGCCACGGCGCAGGAA	0.677													11	40					0	0	0	0	T	1033825	T	T	1033825	3	4	228	1	0	0	0	0	1	0	0	0	15021	527	19	1	526	1	SOX8	16	1033825	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08		1033825	89320928	104	41714											
ERN2	10595	broad.mit.edu	37	chr16	23706682	23706682	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcggaggagccgcttgaCagccactgcccgtccctcaa	7	6	11	17	4	1	1	1	1	0	0	3	3	2	3	4	2	3	1	4	2	1	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr16:23706682C>T	uc002dma.3	-	15	1952	c.1783G>A	c.(1783-1785)GTC>ATC	p.V595I	ERN2_uc010bxp.2_Missense_Mutation_p.V543I	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	547	Protein kinase.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AGCCGCTTGACAGCCACTGCC	0.582													4	15					0	0	0	0	T	23706682	T	T	23706682	3	4	228	1	0	0	0	0	1	0	0	0	5262	478	17	4	1173	4	ERN2	16	23706682	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	22672857	23706682	66648071	105	41715											
TOX3	27324	broad.mit.edu	37	chr16	52473856	52473857	+	Missense_Mutation	DNP	GG	CT	CT																															ctgaacagaacggatggtctGggcttctgctgactcagcag																										TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr16:52473856_52473857GG>CT	uc002egw.2	-	7	1182_1183	c.1011_1012CC>AG	c.(1009-1014)GCCCAG>GCAGAG	p.Q338E	TOX3_uc010vgt.1_Missense_Mutation_p.Q333E|TOX3_uc010vgu.1_Missense_Mutation_p.Q338E	NM_001080430	NP_001073899	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	338					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity				0						CGGATGGTCTGGGCTTCTGCTG	0.436													13	56					0	0	0	0	CT	52473857	CT	CT	52473856	3	2	228	1	0	0	0	0	1	0	0	0	16446	1357	47	4	722	4	TOX3	16	52473856	Missense_Mutation	DNP	GG	TCGA-CV-7178-01A-21D-2012-08	28767174	52473856	37880897	106	41716											
MON1B	22879	broad.mit.edu	37	chr16	77229484	77229484	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggagcggcagcggctgtcgGacctgtaccaccgcctgcat	7	6	14	14	4	0	0	0	0	0	0	1	2	0	2	4	4	4	4	4	4	1	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr16:77229484G>T	uc002fez.2	+	5	1678	c.1348G>T	c.(1348-1350)GAC>TAC	p.D450Y	MON1B_uc010vnf.1_Missense_Mutation_p.D341Y|MON1B_uc010vng.1_Missense_Mutation_p.D304Y|MON1B_uc002ffa.2_Missense_Mutation_p.D330Y	NM_014940	NP_055755	Q7L1V2	MON1B_HUMAN	MON1 homolog B	450							protein binding				0						GCGGCTGTCGGACCTGTACCA	0.627													7	40					5.4927e-09	1.17544e-08	1	0	T	77229484	T	T	77229484	3	4	228	1	0	0	0	0	1	0	0	0	9752	1174	41	2	1362	2	MON1B	16	77229484	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	24755628	77229484	13125269	107	41717											
WWOX	51741	broad.mit.edu	37	chr16	78198111	78198111	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaagtcttttgccctccaTggtgcacatgtgatcttggc	6	13	10	12	0	2	1	0	1	2	0	3	1	3	1	3	2	2	1	3	2	1	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr16:78198111T>G	uc002ffk.2	+	5	566	c.441T>G	c.(439-441)CAT>CAG	p.H147Q	WWOX_uc010vnk.1_Missense_Mutation_p.H34Q|WWOX_uc002ffl.2_Missense_Mutation_p.H147Q|WWOX_uc010che.2_Intron|WWOX_uc002ffj.1_Missense_Mutation_p.H147Q	NM_016373	NP_057457	Q9NZC7	WWOX_HUMAN	WW domain-containing oxidoreductase isoform 1	147	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity				0		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TTGCCCTCCATGGTGCACATG	0.443													15	34					0	0	0	0	G	78198111	G	G	78198111	3	3	228	1	0	0	0	0	1	0	0	0	17482	1461	51	5	463	5	WWOX	16	78198111	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	968627	78198111	12156642	108	41718											
TUBB3	10381	broad.mit.edu	37	chr16	89986186	89986186	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatctgggtggccagtgtcGtcttcagcacgctcttcatc	5	12	10	14	2	5	0	2	0	3	0	7	0	5	0	2	2	1	2	2	2	0	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr16:89986186G>A	uc002fpf.2	+	1	928	c.520G>A	c.(520-522)GTC>ATC	p.V174I	MC1R_uc002fpe.3_Missense_Mutation_p.V174I|TUBB3_uc010ciz.1_5'Flank	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	Error:Variant_position_missing_in_Q13509_after_alignment					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGCCAGTGTCGTCTTCAGCAC	0.632													12	58					0	0	0	0	A	89986186	A	A	89986186	3	1	228	1	0	0	0	0	1	0	0	0	16825	1145	40	1		1	TUBB3	16	89986186	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	11788075	89986186	368567	109	41719											
CYB5D2	124936	broad.mit.edu	37	chr17	4053285	4053285	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgagatgctgacacttcaCaattggctttcattctatga	10	14	8	9	0	3	3	2	3	1	1	3	4	3	3	0	1	1	3	0	1	2	5			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr17:4053285C>T	uc002fxm.3	+	2	939	c.351C>T	c.(349-351)CAC>CAT	p.H117H	CYB5D2_uc010cko.2_Silent_p.H5H|CYB5D2_uc002fxl.3_Silent_p.H5H	NM_144611	NP_653212	Q8WUJ1	NEUFC_HUMAN	cytochrome b5 domain containing 2	117	Cytochrome b5 heme-binding.				nervous system development	extracellular region	heme binding			large_intestine(2)|ovary(1)	3						TGACACTTCACAATTGGCTTT	0.493													32	36					0	0	0	0	T	4053285	T	T	4053285	2	4	228	1	0	0	0	0	0	0	0	1	4142	477	17	4		4	CYB5D2	17	4053285	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08		4053285	77141925	110	41720											
NLGN2	57555	broad.mit.edu	37	chr17	7318427	7318427	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggagtgtctgcgccggaagCcctcccgggagctggtggac	5	7	17	12	3	1	0	0	0	1	0	2	4	2	4	3	5	3	1	3	5	1	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr17:7318427C>G	uc002ggt.1	+	5	1070	c.997C>G	c.(997-999)CCC>GCC	p.P333A		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	333	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				GCGCCGGAAGCCCTCCCGGGA	0.652													26	36					0	0	0	0	G	7318427	G	G	7318427	3	3	228	1	0	0	0	0	1	0	0	0	10516	739	26	4	1015	4	NLGN2	17	7318427	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	3265142	7318427	73876783	111	41721											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577137	+	In_Frame_Del	DEL	CGCACCTCAAAGCTGTTC	-	-																															tcccaggacaggcacaaacaCgcacctcaaagctgttccgt																								rs28934576	by1000genomes	TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr17:7577120_7577137delCGCACCTCAAAGCTGTTC	uc002gim.2	-	8	995_1012	c.801_818delGAACAGCTTTGAGGTGCG	c.(799-819)CGGAACAGCTTTGAGGTGCGT>CGT	p.267_273RNSFEVR>R	TP53_uc002gig.1_Intron|TP53_uc002gih.2_In_Frame_Del_p.267_273RNSFEVR>R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.135_141RNSFEVR>R|TP53_uc010cng.1_In_Frame_Del_p.135_141RNSFEVR>R|TP53_uc002gii.1_In_Frame_Del_p.135_141RNSFEVR>R|TP53_uc010cnh.1_In_Frame_Del_p.267_273RNSFEVR>R|TP53_uc010cni.1_In_Frame_Del_p.267_273RNSFEVR>R|TP53_uc002gij.2_In_Frame_Del_p.267_273RNSFEVR>R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	267_273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(396)|p.R273L(83)|p.V272M(67)|p.R273P(24)|p.V272L(24)|p.F270L(22)|p.E271K(22)|p.R267W(20)|p.F270C(15)|p.E271*(14)|p.R267P(13)|p.R273S(11)|p.R273G(9)|p.F270V(8)|p.V272E(8)|p.F270S(7)|p.R267Q(7)|p.V272A(7)|p.0?(7)|p.E271V(5)|p.R267R(5)|p.F270Y(5)|p.S269C(4)|p.S269N(4)|p.V272G(4)|p.V272fs*73(4)|p.R273fs*72(3)|p.N268H(3)|p.?(3)|p.F270I(3)|p.S269G(3)|p.E271Q(3)|p.S269S(3)|p.V272V(3)|p.E271G(3)|p.E271D(3)|p.G262_F270delGNLLGRNSF(2)|p.R273fs*33(2)|p.G266_E271delGRNSFE(2)|p.N268fs*77(2)|p.N268N(2)|p.G262_S269delGNLLGRNS(2)|p.S269T(2)|p.E271E(2)|p.E271fs*73(1)|p.S269fs*75(1)|p.G266_N268delGRN(1)|p.R273_C275delRVC(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.R267L(1)|p.G262fs*2(1)|p.S269R(1)|p.E271_R273delEVR(1)|p.F270fs*72(1)|p.S269>XXXXX(1)|p.N268F(1)|p.N268fs*8(1)|p.S269fs*21(1)|p.G266fs*4(1)|p.L265_K305del41(1)|p.N268I(1)|p.S269_F270insX(1)|p.R267G(1)|p.F270_D281del12(1)|p.L265_R267delLGR(1)|p.R267fs*78(1)|p.V272_K292del21(1)|p.S269fs*76(1)|p.S269fs*3(1)|p.V272fs*34(1)|p.E271P(1)|p.E271del(1)|p.N268S(1)|p.V272fs*74(1)|p.S269fs*34(1)|p.E271fs*34(1)|p.E271fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAAGCTGTTCCGTCCCAGTA	0.537	R273C(SH10TC_STOMACH)|R273H(NCIH1793_LUNG)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273H(NCIH1975_LUNG)|R273C(SW1710_URINARY_TRACT)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RH30_SOFT_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(TT2609C02_THYROID)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273C(NCIH1048_LUNG)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273C(MFE319_ENDOMETRIUM)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273H(HT29_LARGE_INTESTINE)|R273C(SJRH30_SOFT_TISSUE)|R273C(EFO27_OVARY)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7577137	-	-	7577120	7	5	228	1	0	1	0	1	0	0	0	0	16448	536	19	0	468	0	TP53	17	7577120	In_Frame_Del	DEL	CGCACCTCAAAGCTGTTC	TCGA-CV-7178-01A-21D-2012-08	258693	7577120	73618090	112	41722											
SMCR8	140775	broad.mit.edu	37	chr17	18219330	18219330	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaacccttactgaccatccCcaatgacaccaaagtttttg	12	10	4	15	0	0	2	0	2	0	0	1	2	1	2	6	0	2	1	6	0	4	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr17:18219330C>A	uc002gsy.3	+	1	737	c.227C>A	c.(226-228)CCC>CAC	p.P76H		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	76										central_nervous_system(1)	1						CTGACCATCCCCAATGACACC	0.502													6	166					8.12818e-05	0.000165136	1	0	A	18219330	A	A	18219330	3	1	228	1	0	0	0	0	1	0	0	0	14856	623	22	4	229	4	SMCR8	17	18219330	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	10642210	18219330	62975880	113	41723											
PRPSAP2	5636	broad.mit.edu	37	chr17	18781170	18781170	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctaaattgctggcttccatGatgtgcaaagctggtaagaa	12	12	10	7	0	1	2	0	1	1	1	2	2	2	2	1	2	3	5	1	2	5	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr17:18781170G>C	uc002gup.1	+	6	610	c.399G>C	c.(397-399)ATG>ATC	p.M133I	PRPSAP2_uc002guo.1_Missense_Mutation_p.M47I|PRPSAP2_uc010vyi.1_Missense_Mutation_p.M81I|PRPSAP2_uc010vyj.1_Missense_Mutation_p.M47I|PRPSAP2_uc010vyk.1_Missense_Mutation_p.M121I	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	133					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1						TGGCTTCCATGATGTGCAAAG	0.363													21	64					0	0	0	0	C	18781170	C	C	18781170	3	2	228	1	0	0	0	0	1	0	0	0	12644	1290	45	2	413	2	PRPSAP2	17	18781170	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	561840	18781170	62414040	114	41724											
SRCIN1	80725	broad.mit.edu	37	chr17	36734745	36734745	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccgggagcccactcacctGctctcgcatcctgtcctgct	5	9	9	18	2	2	0	1	0	1	0	5	1	4	1	5	1	4	3	5	1	0	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr17:36734745G>C	uc002hqd.2	-	2	547	c.322C>G	c.(322-324)CAG>GAG	p.Q108E	SRCIN1_uc002hqh.1_Missense_Mutation_p.Q142E	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						CCACTCACCTGCTCTCGCATC	0.701													6	21					0	0	0	0	C	36734745	C	C	36734745	3	2	228	1	0	0	0	0	1	0	0	0	15202	1328	46	4	3301	4	SRCIN1	17	36734745	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	17953575	36734745	44460465	115	41725											
VAT1	10493	broad.mit.edu	37	chr17	41174211	41174213	+	In_Frame_Del	DEL	GGC	-	-																															cagcgcagcagtggcggcgaGgcggcggcggcggcggcccc																										TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr17:41174211_41174213delGGC	uc002icm.1	-	1	247_249	c.127_129delGCC	c.(127-129)GCCdel	p.A43del	VAT1_uc010cyw.1_5'Flank|VAT1_uc010whk.1_In_Frame_Del_p.A43del	NM_006373	NP_006364	Q99536	VAT1_HUMAN	vesicle amine transport protein 1	43						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		gtggcggcgaggcggcggcggcg	0.453													---	---	---								-	41174213	-	-	41174211	7	5	228	1	0	1	0	1	0	0	0	0	17197	987	35	0	1076	0	VAT1	17	41174211	In_Frame_Del	DEL	GGC	TCGA-CV-7178-01A-21D-2012-08	4439466	41174211	40020999	116	41726											
ERN1	2081	broad.mit.edu	37	chr17	62207374	62207376	+	In_Frame_Del	DEL	GCC	-	-																															cagcgtcagcagcagcagcaGccgccgggccggcatggcga																										TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr17:62207374_62207376delGCC	uc002jdz.2	-	1	127_129	c.14_16delGGC	c.(13-18)CGGCTG>CTG	p.R5del		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	5					activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						agcagcagcagcCGCCGGGCCGG	0.685													---	---	---								-	62207376	-	-	62207374	7	5	228	1	0	1	0	1	0	0	0	0	5261	962	34	0	3005	0	ERN1	17	62207374	In_Frame_Del	DEL	GCC	TCGA-CV-7178-01A-21D-2012-08	21033163	62207374	18987836	117	41727											
TNFSF9	8744	broad.mit.edu	37	chr19	6532808	6532808	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttttaacagggcatgtttgcGcagctggtggcccaaaatgg	9	11	13	8	1	0	0	0	0	0	0	0	0	0	0	1	4	3	4	1	4	3	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr19:6532808G>A	uc002mfh.2	+	2	317	c.279G>A	c.(277-279)GCG>GCA	p.A93A		NM_003811	NP_003802	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily,	93	Extracellular (Potential).				apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						GCATGTTTGCGCAGCTGGTGG	0.577													56	71					0	0	0	0	A	6532808	A	A	6532808	2	1	228	1	0	0	0	0	0	0	0	1	16378	1074	38	1		1	TNFSF9	19	6532808	Silent	SNP	G	TCGA-CV-7178-01A-21D-2012-08		6532808	52596175	118	41728											
AP1M1	8907	broad.mit.edu	37	chr19	16319879	16319879	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacaagctggaaacaggggCcccgcggccaccagccaccg	10	1	12	18	3	0	0	0	0	0	0	0	1	0	1	7	4	3	1	7	4	2	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr19:16319879C>T	uc002ndu.2	+	5	610	c.437C>T	c.(436-438)GCC>GTC	p.A146V	AP1M1_uc002ndv.2_Missense_Mutation_p.A146V|AP1M1_uc010xpd.1_Missense_Mutation_p.A146V	NM_032493	NP_115882	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	146					cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(3)|breast(1)	4						GAAACAGGGGCCCCGCGGCCA	0.612													27	49					0	0	0	0	T	16319879	T	T	16319879	3	4	228	1	0	0	0	0	1	0	0	0	734	739	26	4	455	4	AP1M1	19	16319879	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	9787071	16319879	42809104	119	41729											
NCAN	1463	broad.mit.edu	37	chr19	19330033	19330033	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caacgccacgctacttctggGgccactgagggccagtgact	8	7	12	14	2	1	2	0	2	1	0	1	2	1	2	3	3	2	1	3	3	2	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr19:19330033G>A	uc002nlz.2	+	3	482	c.383G>A	c.(382-384)GGG>GAG	p.G128E		NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	128	Ig-like V-type.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CTACTTCTGGGGCCACTGAGG	0.642													9	12					0	0	0	0	A	19330033	A	A	19330033	3	1	228	1	0	0	0	0	1	0	0	0	10258	1232	43	4	389	4	NCAN	19	19330033	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	3010154	19330033	39798950	120	41730											
ZNF100	163227	broad.mit.edu	37	chr19	21910770	21910770	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgctctgcccaaaggtctTggggaaaatgagaacatata	13	9	10	9	0	2	1	0	1	2	1	2	3	2	2	2	3	3	1	2	3	6	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr19:21910770T>A	uc002nqi.2	-	5	543	c.344A>T	c.(343-345)CAA>CTA	p.Q115L	ZNF100_uc002nqh.2_Missense_Mutation_p.Q51L	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCAAAGGTCTTGGGGAAAATG	0.303													7	29					0	0	0	0	A	21910770	A	A	21910770	3	1	228	1	0	0	0	0	1	0	0	0	17780	1812	63	5	1288	5	ZNF100	19	21910770	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	2580737	21910770	37218213	121	41731											
NKPD1	284353	broad.mit.edu	37	chr19	45655923	45655923	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggattcgccgcgccgcctcgTcgtcgatgcggccctgcccg	2	7	14	18	9	0	0	0	0	0	0	4	2	0	1	5	2	2	0	5	2	0	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	ead25229-da3f-49c0-9e0d-f76fcac9d337	g.chr19:45655923T>G	uc010xxi.1	-	4	1772	c.1772A>C	c.(1771-1773)GAC>GCC	p.D591A		NM_198478	NP_940880			NTPase, KAP family P-loop domain containing 1												0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		CGCCGCCTCGTCGTCGATGCG	0.741													3	4					0	0	0	0	G	45655923	G	G	45655923	3	3	228	1	0	0	0	0	1	0	0	0	10500	1667	58	5	730	5	NKPD1	19	45655923	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	23745153	45655923	13473060	122	41732											
PRKCG	5582	broad.mit.edu	37	chr19	54401269	54401269	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccttcccctagtcccacCgaccccaagcgctgcttctt	5	10	5	21	2	1	0	0	0	1	0	4	1	4	0	8	0	2	2	8	0	2	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr19:54401269C>T	uc002qcq.1	+	10	1278	c.996C>T	c.(994-996)ACC>ACT	p.T332T	PRKCG_uc010yef.1_Missense_Mutation_p.P303L|PRKCG_uc010yeg.1_Silent_p.T332T|PRKCG_uc010yeh.1_Silent_p.T219T	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	332					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		cTAGTCCCACCGACCCCAAGC	0.473													11	81					0	0	0	0	T	54401269	T	T	54401269	2	4	228	1	0	0	0	0	0	0	0	1	12574	639	23	1		1	PRKCG	19	54401269	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	8745346	54401269	4727714	123	41733											
NLRP2	55655	broad.mit.edu	37	chr19	55495011	55495011	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgcgtcaagcactgtcgaAacctgcagaaaatgtcactg	12	9	9	11	2	3	1	2	0	1	1	4	2	3	1	1	0	4	2	1	0	4	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr19:55495011A>G	uc002qij.2	+	6	2031	c.1945A>G	c.(1945-1947)AAC>GAC	p.N649D	NLRP2_uc010yfp.1_Missense_Mutation_p.N626D|NLRP2_uc010esn.2_Missense_Mutation_p.N625D|NLRP2_uc010eso.2_Missense_Mutation_p.N646D|NLRP2_uc010esp.2_Missense_Mutation_p.N627D	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	649					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GCACTGTCGAAACCTGCAGAA	0.483													10	46					0	0	0	0	G	55495011	G	G	55495011	3	3	228	1	0	0	0	0	1	0	0	0	10531	14	1	5	1963	5	NLRP2	19	55495011	Missense_Mutation	SNP	A	TCGA-CV-7178-01A-21D-2012-08	1093742	55495011	3633972	124	41734											
FIZ1	84922	broad.mit.edu	37	chr19	56104200	56104200	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctcctccaaggcggccagCgccgcgtacagagccccgca	7	4	12	18	5	0	1	0	0	0	1	2	1	2	1	6	2	4	3	6	2	2	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr19:56104200C>T	uc002qli.3	-	3	1197	c.1107G>A	c.(1105-1107)GCG>GCA	p.A369A	FIZ1_uc002qlj.3_Silent_p.A369A	NM_032836	NP_116225	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	369	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		AGGCGGCCAGCGCCGCGTACA	0.766													4	7					0	0	0	0	T	56104200	T	T	56104200	2	4	228	1	0	0	0	0	0	0	0	1	5932	755	27	1		1	FIZ1	19	56104200	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08	609189	56104200	3024783	125	41735											
ZNF304	57343	broad.mit.edu	37	chr19	57868268	57868268	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagtgaatgtggaaaagcctAcagcagaagctcccaccttg	13	7	10	11	0	0	2	0	1	0	1	1	3	1	3	3	1	4	2	3	1	5	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr19:57868268A>G	uc010ygw.1	+	3	1419	c.1031A>G	c.(1030-1032)TAC>TGC	p.Y344C	ZNF304_uc010etw.2_Missense_Mutation_p.Y391C|ZNF304_uc010etx.2_Missense_Mutation_p.Y302C	NM_020657	NP_065708	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	344	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		GGAAAAGCCTACAGCAGAAGC	0.473													16	37					0	0	0	0	G	57868268	G	G	57868268	3	3	228	1	0	0	0	0	1	0	0	0	17900	391	14	5	1041	5	ZNF304	19	57868268	Missense_Mutation	SNP	A	TCGA-CV-7178-01A-21D-2012-08	1764068	57868268	1260715	126	41736											
TRIB3	57761	broad.mit.edu	37	chr20	368670	368670	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagatgcgagccacccctCtggctgctcctgcgggttcc	5	8	11	17	2	1	1	0	0	1	1	3	2	3	1	6	2	4	3	6	2	0	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr20:368670C>T	uc002wdm.2	+	2	522	c.16C>T	c.(16-18)CTG>TTG	p.L6L	TRIB3_uc002wdn.2_Silent_p.L33L	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	6					apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		AGCCACCCCTCTGGCTGCTCC	0.498													19	76					0	0	0	0	T	368670	T	T	368670	2	4	228	1	0	0	0	0	0	0	0	1	16551	912	32	2		2	TRIB3	20	368670	Silent	SNP	C	TCGA-CV-7178-01A-21D-2012-08		368670	62656850	127	41737											
SNPH	9751	broad.mit.edu	37	chr20	1285638	1285638	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggaggcccgaaaggagaTcaagcagctcaagcaggtca	15	3	14	9	1	3	1	3	0	0	1	3	5	3	2	1	4	3	3	1	4	4	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr20:1285638T>A	uc002wes.2	+	6	661	c.425T>A	c.(424-426)ATC>AAC	p.I142N	SNPH_uc002wet.2_Missense_Mutation_p.I186N	NM_014723	NP_055538	O15079	SNPH_HUMAN	syntaphilin	142	Potential.				synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			ovary(2)	2						CGAAAGGAGATCAAGCAGCTC	0.562													34	94					0	0	0	0	A	1285638	A	A	1285638	3	1	228	1	0	0	0	0	1	0	0	0	14914	1435	50	5	439	5	SNPH	20	1285638	Missense_Mutation	SNP	T	TCGA-CV-7178-01A-21D-2012-08	916968	1285638	61739882	128	41738											
ProSAPiP1	9762	broad.mit.edu	37	chr20	3146664	3146664	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaggtcctggtagcccgAccccccaccgctgctgccgc	4	5	10	22	3	0	0	0	0	0	0	1	1	1	0	9	2	3	3	9	2	1	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr20:3146664A>C	uc002wia.1	-	2	2200	c.802T>G	c.(802-804)TCG>GCG	p.S268A	ProSAPiP1_uc002wib.1_Missense_Mutation_p.S268A	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	268						cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						TGGTAGCCCGACCCCCCACCG	0.662													7	45					0	0	0	0	C	3146664	C	C	3146664	3	2	228	1	0	0	0	0	1	0	0	0	12935	275	10	5	1227	5	ProSAPiP1	20	3146664	Missense_Mutation	SNP	A	TCGA-CV-7178-01A-21D-2012-08	1861026	3146664	59878856	129	41739											
CDS2	8760	broad.mit.edu	37	chr20	5169722	5169722	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actcttctcagaaaacggtcCggatgtaccccttccagatt	10	11	7	13	2	2	2	1	0	2	2	5	3	4	3	4	2	2	1	4	2	3	4			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr20:5169722C>T	uc002wls.2	+	11	1248	c.991C>T	c.(991-993)CGG>TGG	p.R331W	CDS2_uc010zqt.1_RNA|CDS2_uc002wlu.2_Silent_p.S282S|CDS2_uc010zqu.1_Missense_Mutation_p.R211W|CDS2_uc002wlv.2_Missense_Mutation_p.R233W|CDS2_uc010zqv.1_Missense_Mutation_p.R101W	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2	331					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0						GAAAACGGTCCGGATGTACCC	0.383													29	109					0	0	0	0	T	5169722	T	T	5169722	3	4	228	1	0	0	0	0	1	0	0	0	3193	643	23	1	1033	1	CDS2	20	5169722	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	2023058	5169722	57855798	130	41740											
PLCB1	23236	broad.mit.edu	37	chr20	8608996	8608996	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catcgggcgcctggagcagcGcatgatcacagtggtgtatg	8	8	15	10	3	1	1	1	1	0	0	2	2	1	2	1	3	2	3	1	3	1	1			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr20:8608996G>A	uc002wnb.2	+	4	305	c.302G>A	c.(301-303)CGC>CAC	p.R101H	PLCB1_uc010zrb.1_5'UTR|PLCB1_uc010gbv.1_Missense_Mutation_p.R101H|PLCB1_uc002wmz.1_Missense_Mutation_p.R101H|PLCB1_uc002wna.2_Missense_Mutation_p.R101H|PLCB1_uc002wnc.1_5'UTR	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	101					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CTGGAGCAGCGCATGATCACA	0.453													31	75					0	0	0	0	A	8608996	A	A	8608996	3	1	228	1	0	0	0	0	1	0	0	0	12082	1087	38	1	316	1	PLCB1	20	8608996	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	3439274	8608996	54416524	131	41741											
FLRT3	23767	broad.mit.edu	37	chr20	14307545	14307545	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttccatctagaaccaggCgttttagactagtgagacct	10	12	10	9	1	1	3	0	1	1	3	2	4	2	3	3	2	1	2	3	2	4	5			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr20:14307545C>T	uc002wov.1	-	3	1075	c.608G>A	c.(607-609)CGC>CAC	p.R203H	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.R203H	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	203	Extracellular (Potential).|LRR 7.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TAGAACCAGGCGTTTTAGACT	0.438													33	64					0	0	0	0	T	14307545	T	T	14307545	3	4	228	1	0	0	0	0	1	0	0	0	5972	768	27	1	1345	1	FLRT3	20	14307545	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	5698549	14307545	48717975	132	41742											
EPB41L1	2036	broad.mit.edu	37	chr20	34797434	34797434	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagggctgagggagggctccGaggagaaagtcaaaccacca	13	3	15	10	1	1	2	1	1	0	1	2	5	2	3	3	4	1	2	3	4	2	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr20:34797434G>A	uc002xfb.2	+	15	1864	c.1693G>A	c.(1693-1695)GAG>AAG	p.E565K	EPB41L1_uc002xeu.2_Missense_Mutation_p.E491K|EPB41L1_uc010zvo.1_Missense_Mutation_p.E565K|EPB41L1_uc002xev.2_Missense_Mutation_p.E565K|EPB41L1_uc002xew.2_Missense_Mutation_p.E456K|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Missense_Mutation_p.E491K|EPB41L1_uc010gfq.2_Missense_Mutation_p.E664K	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	565					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					GGAGGGCTCCGAGGAGAAAGT	0.552													6	32					0	0	0	0	A	34797434	A	A	34797434	3	1	228	1	0	0	0	0	1	0	0	0	5176	1059	37	1	1747	1	EPB41L1	20	34797434	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	20489889	34797434	28228086	133	41743											
EP300	2033	broad.mit.edu	37	chr22	41489079	41489079	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actctcatctccggccctctCggcgtccgccagcgatggca	5	8	10	18	5	3	0	1	0	3	0	7	1	4	0	4	3	1	1	4	3	0	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr22:41489079C>A	uc003azl.3	+	1	466	c.71C>A	c.(70-72)TCG>TAG	p.S24*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	24	Interaction with ALX1.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CCGGCCCTCTCGGCGTCCGCC	0.542			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				19	105					1.67942e-08	3.57015e-08	1	0	A	41489079	A	A	41489079	4	1	228	1	0	0	0	0	0	1	0	0	5172	893	31	3	73	3	EP300	22	41489079	Nonsense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08		41489079	9815487	134	41744											
SHANK3	85358	broad.mit.edu	37	chr22	51143288	51143288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacgggagacttcctcatcGaggtgaggtcgttctggccg	6	9	15	11	4	2	2	1	1	1	1	5	4	3	2	2	4	0	2	2	4	0	2			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chr22:51143288G>A	uc003bne.1	+	16	1942	c.1942G>A	c.(1942-1944)GAG>AAG	p.E648K	SHANK3_uc003bnf.1_Missense_Mutation_p.E103K	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	648										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CTTCCTCATCGAGGTGAGGTC	0.692													9	47					0	0	0	0	A	51143288	A	A	51143288	3	1	228	1	0	0	0	0	1	0	0	0	14331	1059	37	1	2004	1	SHANK3	22	51143288	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08	9654209	51143288	161278	135	41745											
ZXDB	158586	broad.mit.edu	37	chrX	57619097	57619097	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgctcctgcccagcagcccGggtgtctgatcgccccgcaa	5	6	11	19	4	1	1	0	1	1	0	3	1	2	1	6	1	3	3	6	1	1	0			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chrX:57619097G>A	uc004dvd.2	+	1	829	c.616G>A	c.(616-618)GGG>AGG	p.G206R		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						CCAGCAGCCCGGGTGTCTGAT	0.711													3	24					0	0	0	0	A	57619097	A	A	57619097	3	1	228	1	0	0	0	0	1	0	0	0	18318	1116	39	1	618	1	ZXDB	23	57619097	Missense_Mutation	SNP	G	TCGA-CV-7178-01A-21D-2012-08		57619097	97651463	136	41746											
ZCCHC5	203430	broad.mit.edu	37	chrX	77912862	77912862	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atccagagagtgctttcatcCcagttcagctcttgagcaat	10	12	8	11	0	3	2	2	1	1	1	5	3	5	2	2	0	3	4	2	0	1	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chrX:77912862C>G	uc004edc.1	-	2	1352	c.1056G>C	c.(1054-1056)TGG>TGC	p.W352C		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	352							nucleic acid binding|zinc ion binding			ovary(1)	1						TGCTTTCATCCCAGTTCAGCT	0.478													18	40					0	0	0	0	G	77912862	G	G	77912862	3	3	228	1	0	0	0	0	1	0	0	0	17658	624	22	4	375	4	ZCCHC5	23	77912862	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	20293765	77912862	77357698	137	41747											
FRMD7	90167	broad.mit.edu	37	chrX	131212552	131212553	+	Frame_Shift_Ins	INS	-	A	A																															ctggggtggcttgtccacatINSaaaaaaagacctggggaggc																										TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chrX:131212552_131212553insA	uc004ewn.2	-	12	1670_1671	c.1492_1493insT	c.(1492-1494)TATfs	p.Y498fs	FRMD7_uc011muy.1_Frame_Shift_Ins_p.Y483fs	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	498					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					CTTGTCCACATAAAAAAAGACC	0.5													---	---	---								A	131212553	A	A	131212552	7	5	228	1	0	1	1	0	0	0	0	0	6089	1406	49	0	655	0	FRMD7	23	131212552	Frame_Shift_Ins	INS	-	TCGA-CV-7178-01A-21D-2012-08	53299690	131212552	24058008	138	41748											
SPANXN2	494119	broad.mit.edu	37	chrX	142795518	142795518	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcttcctgtagtaatacaCtattattgttagatattcta	12	18	5	6	0	1	1	0	0	1	1	2	1	2	1	1	0	2	4	1	0	8	11			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	2c4a9e5c-8325-492c-98f2-e9ed96514b8c	g.chrX:142795518C>A	uc004fbz.2	-	2	914	c.160G>T	c.(160-162)GTG>TTG	p.V54L		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	54										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TAGTAATACACTATTATTGTT	0.433													52	88					1.19451e-25	2.66277e-25	1	0	A	142795518	A	A	142795518	3	1	228	1	0	0	0	0	1	0	0	0	15057	565	20	4	386	4	SPANXN2	23	142795518	Missense_Mutation	SNP	C	TCGA-CV-7178-01A-21D-2012-08	11582966	142795518	12475042	139	41749											
MAGEA12	4111	broad.mit.edu	37	chrX	151896231	151896231	+	RNA	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctggtcggagtggctggAtagtgttggcccactccatt	5	12	15	9	1	0	0	0	0	0	0	2	2	1	2	2	6	0	3	2	6	1	3			TCGA-CV-7178-01A-21D-2012-08	TCGA-CV-7178-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f30774f-2b8c-4057-abd1-a9dd1e49ec78	ead25229-da3f-49c0-9e0d-f76fcac9d337	g.chrX:151896231A>G	uc004fgb.2	-	4		c.536T>C						P43365	MAGAC_HUMAN	Homo sapiens melanoma antigen family A, 12, mRNA (cDNA clone MGC:4914 IMAGE:3450217), complete cds.											skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTGGCTGGATAGTGTTGGC	0.517													8	33					0	0	0	0	G	151896231	G	G	151896231	1	3	228	0	1	0	0	0	0	0	0	0	9217	348	12	5		5	MAGEA12	23	151896231	RNA	SNP	A	TCGA-CV-7178-01A-21D-2012-08	9100713	151896231	3374329	140	41750											
VPS13D	55187	broad.mit.edu	37	chr1	12331121	12331121	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacaatataacaagctgaaGatgcagaccaaggcagaaat	20	5	9	7	0	0	5	0	1	0	4	0	5	0	5	1	1	3	3	1	1	7	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:12331121G>A	uc001atv.2	+	17	2184	c.2043G>A	c.(2041-2043)AAG>AAA	p.K681K	VPS13D_uc001atw.2_Silent_p.K681K	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	681					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACAAGCTGAAGATGCAGACCA	0.458													4	52					0	0	0	0	A	12331121	A	A	12331121	2	1	229	1	0	0	0	0	0	0	0	1	17260	933	33	2		2	VPS13D	1	12331121	Silent	SNP	G	TCGA-CV-7180-01A-11D-2012-08		12331121	236919500	1	41751											
NFYC	4802	broad.mit.edu	37	chr1	41228713	41228713	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacaggagagatccagcagAtcccggtgagtcctgccctg	10	6	12	13	1	0	3	0	1	0	2	3	5	3	4	4	2	2	1	4	2	0	0			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:41228713A>T	uc001cge.2	+	6	723	c.715A>T	c.(715-717)ATC>TTC	p.I239F	NFYC_uc010ojm.1_Missense_Mutation_p.I145F|NFYC_uc001cfx.3_Missense_Mutation_p.I239F|NFYC_uc009vwd.2_Missense_Mutation_p.I239F|NFYC_uc001cfz.2_Missense_Mutation_p.I239F|NFYC_uc010ojn.1_Missense_Mutation_p.I201F|NFYC_uc001cfy.3_Missense_Mutation_p.I239F|NFYC_uc001cgc.2_Missense_Mutation_p.I205F|NFYC_uc001cgb.2_Missense_Mutation_p.I239F|NFYC_uc001cgd.3_Missense_Mutation_p.I239F	NM_001142588	NP_001136060	Q13952	NFYC_HUMAN	nuclear transcription factor Y, gamma isoform 1	239					protein folding|regulation of transcription from RNA polymerase II promoter	CCAAT-binding factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|kidney(1)	3	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.72e-17)			GATCCAGCAGATCCCGGTGAG	0.433													8	11					0	0	0	0	T	41228713	T	T	41228713	3	4	229	1	0	0	0	0	1	0	0	0	10445	333	12	5	737	5	NFYC	1	41228713	Missense_Mutation	SNP	A	TCGA-CV-7180-01A-11D-2012-08	28897592	41228713	208021908	2	41752											
KIAA0467	23334	broad.mit.edu	37	chr1	43912750	43912750	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggtgcccatctggtgctgcGgcacggctaccacctcacca	7	7	11	16	2	2	0	1	0	1	0	2	0	2	0	4	4	4	3	4	4	1	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:43912750G>A	uc001cjk.1	+	51	6962	c.6500G>A	c.(6499-6501)CGG>CAG	p.R2167Q	KIAA0467_uc001cjl.1_Missense_Mutation_p.R155Q	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	3066						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGGTGCTGCGGCACGGCTAC	0.597													3	31					0	0	0	0	A	43912750	A	A	43912750	3	1	229	1	0	0	0	0	1	0	0	0	8217	1116	39	1	6694	1	KIAA0467	1	43912750	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	2684037	43912750	205337871	3	41753											
ACOT11	26027	broad.mit.edu	37	chr1	55058224	55058224	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctttcctctccccagtgttgGacaagtggtgaatatcaagg	9	12	10	10	0	2	1	1	1	1	0	4	2	3	2	3	3	0	1	3	3	4	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:55058224G>T	uc001cxm.1	+	4	399	c.317G>T	c.(316-318)GGA>GTA	p.G106V	ACOT11_uc001cxj.1_5'UTR|ACOT11_uc001cxk.2_Missense_Mutation_p.G72V|ACOT11_uc001cxl.1_Missense_Mutation_p.G106V	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	106	Acyl coenzyme A hydrolase 1.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						CCCAGTGTTGGACAAGTGGTG	0.607													13	53					4.36969e-10	5.69719e-10	1	0	T	55058224	T	T	55058224	3	4	229	1	0	0	0	0	1	0	0	0	149	1174	41	2	331	2	ACOT11	1	55058224	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	11145474	55058224	194192397	4	41754											
CCDC18	343099	broad.mit.edu	37	chr1	93680428	93680428	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagaagctgaaaattctgatTtgaaggttaacatggctcac	14	12	9	6	0	2	4	1	3	1	1	2	4	2	4	0	2	2	3	0	2	6	4			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:93680428T>A	uc001dpq.2	+	12	2146	c.1978T>A	c.(1978-1980)TTG>ATG	p.L660M	CCDC18_uc009wdl.1_Missense_Mutation_p.L221M	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	541	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AAATTCTGATTTGAAGGTTAA	0.378													3	27					0	0	0	0	A	93680428	A	A	93680428	3	1	229	1	0	0	0	0	1	0	0	0	2807	1838	64	5	2024	5	CCDC18	1	93680428	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	38622204	93680428	155570193	5	41755											
VPS72	6944	broad.mit.edu	37	chr1	151149264	151149264	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtaagcctcacgaatgatCttgaaggctcgagcagtggc	10	10	12	9	2	2	2	1	2	1	0	3	4	2	2	1	2	2	3	1	2	3	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:151149264C>T	uc001exe.1	-	6	994	c.951G>A	c.(949-951)AAG>AAA	p.K317K	TMOD4_uc001exd.2_5'Flank|TMOD4_uc001exc.3_5'Flank|TMOD4_uc010pct.1_5'Flank	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	317					chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CACGAATGATCTTGAAGGCTC	0.597													8	88					0	0	0	0	T	151149264	T	T	151149264	2	4	229	1	0	0	0	0	0	0	0	1	17285	912	32	2		2	VPS72	1	151149264	Silent	SNP	C	TCGA-CV-7180-01A-11D-2012-08	57468836	151149264	98101357	6	41756											
LINGO4	339398	broad.mit.edu	37	chr1	151774040	151774040	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagcacaggcagggggggAcatgccaaagtccaggtggc	10	3	17	11	0	0	0	0	0	0	0	1	1	1	1	3	6	2	2	3	6	1	0			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:151774040A>G	uc001ezf.1	-	2	1331	c.1141T>C	c.(1141-1143)TCC>CCC	p.S381P		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	381	Extracellular (Potential).|LRRCT.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCAGGGGGGGACATGCCAAAG	0.622													10	55					0	0	0	0	G	151774040	G	G	151774040	3	3	229	1	0	0	0	0	1	0	0	0	8859	275	10	5	644	5	LINGO4	1	151774040	Missense_Mutation	SNP	A	TCGA-CV-7180-01A-11D-2012-08	624776	151774040	97476581	7	41757											
PAPPA2	60676	broad.mit.edu	37	chr1	176661264	176661264	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttttttgtctccacagatGataactgcactgacaacttc	10	14	5	12	0	1	3	0	2	1	1	3	3	1	3	2	0	3	1	2	0	2	5			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:176661264G>A	uc001gkz.2	+	6	3598	c.2434G>A	c.(2434-2436)GAT>AAT	p.D812N	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	812					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CTCCACAGATGATAACTGCAC	0.458											OREG0014001	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	76					0	0	0	0	A	176661264	A	A	176661264	3	1	229	1	0	0	0	0	1	0	0	0	11487	1290	45	2	2505	2	PAPPA2	1	176661264	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	24887224	176661264	72589357	8	41758											
CFHR2	3080	broad.mit.edu	37	chr1	196918742	196918742	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttggactcgcataacgtgCgcagaagaaggatggtcacc	11	9	12	9	3	1	2	1	0	0	2	2	4	1	4	1	3	2	2	1	3	3	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:196918742C>T	uc001gtq.1	+	2	293	c.216C>T	c.(214-216)TGC>TGT	p.C72C	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	72	Sushi 1.					extracellular region				skin(2)|ovary(1)	3						GCATAACGTGCGCAGAAGAAG	0.408													9	21					0	0	0	0	T	196918742	T	T	196918742	2	4	229	1	0	0	0	0	0	0	0	1	3300	776	27	1		1	CFHR2	1	196918742	Silent	SNP	C	TCGA-CV-7180-01A-11D-2012-08	20257478	196918742	52331879	9	41759											
NFASC	23114	broad.mit.edu	37	chr1	204978741	204978741	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggttcattgggcttatgTgcgccatcgccctcctggtg	3	13	13	12	2	1	0	1	0	0	0	3	0	2	0	3	3	1	3	3	3	1	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:204978741T>G	uc001hbj.2	+	28	3674	c.3346T>G	c.(3346-3348)TGC>GGC	p.C1116G	NFASC_uc010pra.1_Missense_Mutation_p.C1050G|NFASC_uc001hbi.2_Missense_Mutation_p.C1045G|NFASC_uc010prb.1_Missense_Mutation_p.C1065G|NFASC_uc010prc.1_Missense_Mutation_p.C616G|NFASC_uc001hbl.1_Missense_Mutation_p.C192G|NFASC_uc001hbm.1_Missense_Mutation_p.C139G|NFASC_uc009xbh.1_5'UTR	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	1223	Helical; (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGGGCTTATGTGCGCCATCGC	0.592													7	49					0	0	0	0	G	204978741	G	G	204978741	3	3	229	1	0	0	0	0	1	0	0	0	10413	1696	59	5	3861	5	NFASC	1	204978741	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	8059999	204978741	44271880	10	41760											
VASH2	79805	broad.mit.edu	37	chr1	213147325	213147325	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgcaagtgcccactctcCgacccaagtgagaagccggg	10	5	11	15	2	1	1	0	1	1	1	2	3	1	1	5	1	3	1	5	1	3	0			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:213147325C>T	uc001hjy.2	+	6	1112	c.908C>T	c.(907-909)CCG>CTG	p.P303L	VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Missense_Mutation_p.P238L|VASH2_uc010ptn.1_Missense_Mutation_p.P199L|VASH2_uc001hjw.2_Missense_Mutation_p.P259L	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3	303					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		GCCCACTCTCCGACCCAAGTG	0.567													4	58					0	0	0	0	T	213147325	T	T	213147325	3	4	229	1	0	0	0	0	1	0	0	0	17194	652	23	1	930	1	VASH2	1	213147325	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	8168584	213147325	36103296	11	41761											
DISP1	84976	broad.mit.edu	37	chr1	223178539	223178539	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgtgtcacttcttctctcTgaatcagagatgtagctgcc	7	14	9	11	1	5	2	2	1	3	1	6	3	5	2	1	0	2	2	1	0	2	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:223178539T>C	uc001hnu.1	+	8	3947	c.3800T>C	c.(3799-3801)CTG>CCG	p.L1267P		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1267					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TTCTTCTCTCTGAATCAGAGA	0.517													3	149					0	0	0	0	C	223178539	C	C	223178539	3	2	229	1	0	0	0	0	1	0	0	0	4561	1580	55	5	3826	5	DISP1	1	223178539	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	10031214	223178539	26072082	12	41762											
OBSCN	84033	broad.mit.edu	37	chr1	228467143	228467143	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgcccgcctggtggtctCaggtgagcactcccgccccg	3	8	12	18	3	2	1	1	1	2	0	4	1	3	1	5	3	2	1	5	3	0	0			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr1:228467143C>T	uc009xez.1	+	27	7438	c.7394C>T	c.(7393-7395)TCA>TTA	p.S2465L	OBSCN_uc001hsn.2_Missense_Mutation_p.S2465L|OBSCN_uc001hsp.1_Missense_Mutation_p.S164L|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2465					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTGGTGGTCTCAGGTGAGCAC	0.682													4	38					0	0	0	0	T	228467143	T	T	228467143	3	4	229	1	0	0	0	0	1	0	0	0	10866	838	29	2	7496	2	OBSCN	1	228467143	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	5288604	228467143	20783478	13	41763											
SLC30A3	7781	broad.mit.edu	37	chr2	27480853	27480853	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tagtcgctgtgcagcaggcgGacgaaggccaggtacaggag	10	5	17	9	3	0	0	0	0	0	0	1	3	0	2	1	5	3	4	1	5	3	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:27480853G>T	uc002rjk.2	-	4	684	c.498C>A	c.(496-498)GTC>GTA	p.V166V	SLC30A3_uc002rjj.2_5'UTR|SLC30A3_uc010ylh.1_Silent_p.V161V	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	166	Helical; (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCAGCAGGCGGACGAAGGCCA	0.627													13	42					1.61879e-10	2.13764e-10	1	0	T	27480853	T	T	27480853	2	4	229	1	0	0	0	0	0	0	0	1	14620	1161	41	2		2	SLC30A3	2	27480853	Silent	SNP	G	TCGA-CV-7180-01A-11D-2012-08		27480853	215718520	14	41764											
SLC30A6	55676	broad.mit.edu	37	chr2	32422829	32422829	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccttccccgaatgaatcCatttgttttgattgatcttg	7	18	6	10	1	1	3	0	3	1	0	4	4	4	3	4	0	0	1	4	0	2	7			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:32422829C>A	uc002roe.1	+	10	636	c.599C>A	c.(598-600)CCA>CAA	p.P200Q	SLC30A6_uc002rof.1_Missense_Mutation_p.P240Q|SLC30A6_uc010ymw.1_Missense_Mutation_p.P171Q|SLC30A6_uc010ezr.1_Missense_Mutation_p.P200Q|SLC30A6_uc002rog.1_Missense_Mutation_p.P3Q|SLC30A6_uc010ezs.1_Missense_Mutation_p.P126Q|SLC30A6_uc002roh.1_Missense_Mutation_p.P3Q	NM_017964	NP_060434	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter),	200	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CGAATGAATCCATTTGTTTTG	0.338													23	77					1.37657e-19	1.86561e-19	1	0	A	32422829	A	A	32422829	3	1	229	1	0	0	0	0	1	0	0	0	14623	594	21	4	637	4	SLC30A6	2	32422829	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	4941976	32422829	210776544	15	41765											
BCL11A	53335	broad.mit.edu	37	chr2	60688312	60688312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaagtgtccctgtggccctCggcctcggccaggtggccgc	3	7	15	16	3	0	0	0	0	0	0	3	0	1	0	5	5	0	1	5	5	1	0			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:60688312C>T	uc002sae.1	-	4	1963	c.1735G>A	c.(1735-1737)GAG>AAG	p.E579K	BCL11A_uc002sab.2_Missense_Mutation_p.E579K|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.E248K|BCL11A_uc010ypj.1_Missense_Mutation_p.E545K|BCL11A_uc002sad.1_Missense_Mutation_p.E427K|BCL11A_uc002saf.1_Missense_Mutation_p.E545K	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	579					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CTGTGGCCCTCGGCCTCGGCC	0.667			T	IGH@	B-CLL								5	39					0	0	0	0	T	60688312	T	T	60688312	3	4	229	1	0	0	0	0	1	0	0	0	1365	893	31	1	882	1	BCL11A	2	60688312	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	28265483	60688312	182511061	16	41766											
GPAT2	150763	broad.mit.edu	37	chr2	96689170	96689170	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcgccctgtgtcacaggCtggccgggagcctggggtct	3	9	16	13	2	2	0	1	0	1	0	3	1	2	1	3	5	1	1	3	5	0	0			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:96689170C>A	uc002svf.2	-	18	2138	c.1915G>T	c.(1915-1917)GCC>TCC	p.A639S	GPAT2_uc002svd.2_Missense_Mutation_p.A458S|GPAT2_uc002sve.2_Missense_Mutation_p.A441S|GPAT2_uc002svg.2_Missense_Mutation_p.A518S|GPAT2_uc010yuh.1_Missense_Mutation_p.A568S|GPAT2_uc002svh.2_Intron	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	639					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						GTGTCACAGGCTGGCCGGGAG	0.587													5	47					3.59834e-05	4.30963e-05	1	0	A	96689170	A	A	96689170	3	1	229	1	0	0	0	0	1	0	0	0	6627	797	28	4	492	4	GPAT2	2	96689170	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	36000858	96689170	146510203	17	41767											
NMS	129521	broad.mit.edu	37	chr2	101096979	101096979	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctcggggactgctgcagtgGacttcaccaagaaggtacac	10	7	13	11	1	1	1	1	0	0	1	2	3	1	3	1	4	3	4	1	4	3	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:101096979G>T	uc002tan.1	+	7	365	c.358G>T	c.(358-360)GAC>TAC	p.D120Y		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	120					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						TGCTGCAGTGGACTTCACCAA	0.557													11	48					2.62699e-14	3.51402e-14	1	0	T	101096979	T	T	101096979	3	4	229	1	0	0	0	0	1	0	0	0	10556	1174	41	2	384	2	NMS	2	101096979	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	4407809	101096979	142102394	18	41768											
NEB	4703	broad.mit.edu	37	chr2	152534283	152534283	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtagtcttccttgtagacGttctacagcaatggagaaaa	12	13	9	7	1	2	2	0	0	2	2	3	3	3	2	1	1	2	4	1	1	6	7			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:152534283G>A	uc010fnx.2	-	34	3761	c.3570C>T	c.(3568-3570)AAC>AAT	p.N1190N		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1190	Nebulin 29.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCTTGTAGACGTTCTACAGCA	0.463													43	166					0	0	0	0	A	152534283	A	A	152534283	2	1	229	1	0	0	0	0	0	0	0	1	10356	1136	40	1		1	NEB	2	152534283	Silent	SNP	G	TCGA-CV-7180-01A-11D-2012-08	51437304	152534283	90665090	19	41769											
PLA2R1	22925	broad.mit.edu	37	chr2	160825846	160825846	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctgtgtcccagttctggtaTatcactggtgttccatctct	5	16	8	12	0	3	0	1	0	2	0	6	0	5	0	3	2	0	3	3	2	2	4			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:160825846T>C	uc002ube.1	-	19	2892	c.2685A>G	c.(2683-2685)ATA>ATG	p.I895M	PLA2R1_uc010zcp.1_Missense_Mutation_p.I895M|PLA2R1_uc002ubf.2_Missense_Mutation_p.I895M	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	895	Extracellular (Potential).|C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						AGTTCTGGTATATCACTGGTG	0.393													8	41					0	0	0	0	C	160825846	C	C	160825846	3	2	229	1	0	0	0	0	1	0	0	0	12065	1396	49	5	1762	5	PLA2R1	2	160825846	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	8291563	160825846	82373527	20	41770											
UGT1A10	54575	broad.mit.edu	37	chr2	234545236	234545236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	actgctgacctgtggctttgCcgaggcagggaagctgctgg	6	9	16	10	1	0	1	0	1	0	0	0	3	0	2	2	4	4	5	2	4	1	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr2:234545236C>T	uc002vur.2	+	1	114	c.68C>T	c.(67-69)GCC>GTC	p.A23V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Missense_Mutation_p.A23V	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	23				MARAGWTSPVPLCVCLLLTCGFA -> MAPRRVDQPRSFMC VSTADLWLC (in Ref. 1).	flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGTGGCTTTGCCGAGGCAGGG	0.592													4	101					0	0	0	0	T	234545236	T	T	234545236	3	4	229	1	0	0	0	0	1	0	0	0	17013	739	26	4	70	4	UGT1A10	2	234545236	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	73719390	234545236	8654137	21	41771											
BSN	8927	broad.mit.edu	37	chr3	49688471	49688471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacctgccacccctgtcGtcaaggctgttccagaagcc	8	8	9	16	1	1	2	1	1	0	1	3	2	2	2	6	1	3	2	6	1	3	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr3:49688471G>A	uc003cxe.3	+	4	2059	c.1945G>A	c.(1945-1947)GTC>ATC	p.V649I		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	649					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CACCCCTGTCGTCAAGGCTGT	0.592													9	55					0	0	0	0	A	49688471	A	A	49688471	3	1	229	1	0	0	0	0	1	0	0	0	1535	1145	40	1	1959	1	BSN	3	49688471	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08		49688471	148333959	22	41772											
HTT	3064	broad.mit.edu	37	chr4	3156043	3156043	+	Frame_Shift_Del	DEL	C	-	-																															gccttgccttctctaacaaaCcccccttctctaagtcccat																										TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr4:3156043delC	uc011bvq.1	+	28	3673	c.3528delC	c.(3526-3528)AACfs	p.N1176fs		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1174					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CTCTAACAAACCCCCCTTCTC	0.383													---	---	---								-	3156043	-	-	3156043	7	5	229	1	0	1	0	1	0	0	0	0	7496	506	18	0	3628	0	HTT	4	3156043	Frame_Shift_Del	DEL	C	TCGA-CV-7180-01A-11D-2012-08		3156043	187998233	23	41773											
UGT2B10	7365	broad.mit.edu	37	chr4	69885860	69885860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	taaagatgtaggataaacttCgagtttaagagtggatgagt	15	12	12	2	1	0	3	0	1	0	2	1	6	0	5	0	2	1	2	0	2	6	6			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr4:69885860C>G	uc011cao.1	-	2	245	c.109G>C	c.(109-111)GAA>CAA	p.E37Q	UGT2B10_uc011can.1_Missense_Mutation_p.E37Q			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	74					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GGATAAACTTCGAGTTTAAGA	0.358													22	55					0	0	0	0	G	69885860	G	G	69885860	3	3	229	1	0	0	0	0	1	0	0	0	17024	893	31	3	2981	3	UGT2B10	4	69885860	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	66729817	69885860	121268416	24	41774											
EMCN	51705	broad.mit.edu	37	chr4	101386581	101386581	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaaatcctcatacttactCttgggtttggaactttgtaa	11	15	6	9	0	2	0	1	0	1	0	3	1	3	1	1	2	3	2	1	2	5	6			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr4:101386581C>A	uc003hvr.2	-	4	554	c.375G>T	c.(373-375)AAG>AAT	p.K125N	EMCN_uc011cel.1_Missense_Mutation_p.K125N|EMCN_uc011cem.1_Missense_Mutation_p.K125N	NM_016242	NP_057326	Q9ULC0	MUCEN_HUMAN	endomucin isoform 1	125	Thr-rich.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(123;2.49e-08)		CATACTTACTCTTGGGTTTGG	0.373													16	48					4.7546e-09	6.12155e-09	1	0	A	101386581	A	A	101386581	3	1	229	1	0	0	0	0	1	0	0	0	5110	927	32	2	442	2	EMCN	4	101386581	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	31500721	101386581	89767695	25	41775											
TBCK	93627	broad.mit.edu	37	chr4	107170083	107170083	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agattaatgacaaacctttaTaatgtccaaacaaccatgct	17	11	4	9	0	0	2	0	1	0	1	1	2	1	2	3	0	4	1	3	0	6	4			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr4:107170083T>C	uc010ilv.2	-	8	1080	c.715A>G	c.(715-717)ATA>GTA	p.I239V	TBCK_uc003hyb.2_5'Flank|TBCK_uc003hye.2_Missense_Mutation_p.I200V|TBCK_uc003hyc.2_Missense_Mutation_p.I176V|TBCK_uc003hyd.2_Missense_Mutation_p.I67V|TBCK_uc003hyf.2_Missense_Mutation_p.I239V	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	239	Protein kinase.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						CAAACCTTTATAATGTCCAAA	0.179													7	19					0	0	0	0	C	107170083	C	C	107170083	3	2	229	1	0	0	0	0	1	0	0	0	15702	1406	49	5	2042	5	TBCK	4	107170083	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	5783502	107170083	83984193	26	41776											
CDH18	1016	broad.mit.edu	37	chr5	19721469	19721469	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactaacctgttttagggtcGacggagaagtagggttgtcc	9	11	13	8	2	0	1	0	0	0	1	2	3	1	1	2	3	1	3	2	3	4	5			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr5:19721469G>A	uc003jgc.2	-	4	1007	c.630C>T	c.(628-630)GTC>GTT	p.V210V	CDH18_uc003jgd.2_Silent_p.V210V|CDH18_uc011cnm.1_Silent_p.V210V	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	210	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TTTTAGGGTCGACGGAGAAGT	0.453													22	70					0	0	0	0	A	19721469	A	A	19721469	2	1	229	1	0	0	0	0	0	0	0	1	3118	1045	37	1		1	CDH18	5	19721469	Silent	SNP	G	TCGA-CV-7180-01A-11D-2012-08		19721469	161193791	27	41777											
PDE4D	5144	broad.mit.edu	37	chr5	58270507	58270507	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actgttacgtgtcaggagaaCgatcatctatgacacaggct	12	10	10	9	2	3	2	2	1	1	1	3	4	3	2	0	2	2	2	0	2	3	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr5:58270507C>T	uc003jsa.2	-	15	2586	c.2414G>A	c.(2413-2415)CGT>CAT	p.R805H	PDE4D_uc003jrx.2_Missense_Mutation_p.R669H|PDE4D_uc003jry.2_Missense_Mutation_p.R503H|PDE4D_uc003jrz.2_Missense_Mutation_p.R741H|PDE4D_uc003jsb.2_Missense_Mutation_p.R744H|PDE4D_uc003jrt.2_Missense_Mutation_p.R503H|PDE4D_uc003jru.2_Missense_Mutation_p.R581H|PDE4D_uc003jrv.2_Missense_Mutation_p.R675H|PDE4D_uc003jrw.2_Missense_Mutation_p.R683H|PDE4D_uc003jrs.2_Missense_Mutation_p.R514H	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	805					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GTCAGGAGAACGATCATCTAT	0.433													29	140					0	0	0	0	T	58270507	T	T	58270507	3	4	229	1	0	0	0	0	1	0	0	0	11696	536	19	1	19	1	PDE4D	5	58270507	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	38549038	58270507	122644753	28	41778											
CARTPT	9607	broad.mit.edu	37	chr5	71016344	71016344	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgttgtttcagtgtgacgccGgtgagcagtgtgcagtgagg	6	12	17	6	2	1	3	1	3	0	0	1	3	1	3	1	2	2	4	1	2	0	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr5:71016344G>A	uc003kbv.1	+	3	380	c.253G>A	c.(253-255)GGT>AGT	p.G85S		NM_004291	NP_004282	Q16568	CART_HUMAN	cocaine- and amphetamine-regulated transcript	85					activation of MAPKK activity|adult feeding behavior|cellular glucose homeostasis|cellular response to starvation|circadian regulation of gene expression|negative regulation of appetite|negative regulation of bone resorption|negative regulation of osteoclast differentiation|neuropeptide signaling pathway|positive regulation of blood pressure|positive regulation of epinephrine secretion|positive regulation of transmission of nerve impulse|synaptic transmission	extracellular space				ovary(1)	1		Lung NSC(167;0.00153)|Ovarian(174;0.0175)|Prostate(74;0.11)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;8.4e-56)	Amphetamine(DB00182)	GTGTGACGCCGGTGAGCAGTG	0.507													6	8					0	0	0	0	A	71016344	A	A	71016344	3	1	229	1	0	0	0	0	1	0	0	0	2671	1116	39	1	263	1	CARTPT	5	71016344	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	12745837	71016344	109898916	29	41779											
PCDH12	51294	broad.mit.edu	37	chr5	141334957	141334957	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcagcgtcctgtacagggtCggggtgaggtggaagggggc	6	6	21	8	3	0	1	0	1	0	0	2	2	1	2	1	7	2	2	1	7	2	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr5:141334957C>T	uc003llx.2	-	1	3671	c.2460G>A	c.(2458-2460)CCG>CCA	p.P820P		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	820	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTACAGGGTCGGGGTGAGGT	0.612													12	34					0	0	0	0	T	141334957	T	T	141334957	2	4	229	1	0	0	0	0	0	0	0	1	11564	871	31	1		1	PCDH12	5	141334957	Silent	SNP	C	TCGA-CV-7180-01A-11D-2012-08	70318613	141334957	39580303	30	41780											
PRICKLE4	29964	broad.mit.edu	37	chr6	41753268	41753268	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcgcccgcgctgcccggCttgtgaccaggtacagcctg	4	7	14	16	4	0	1	0	1	0	0	0	1	0	1	4	2	4	4	4	2	1	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr6:41753268C>T	uc011duf.1	+	6	820	c.572C>T	c.(571-573)GCT>GTT	p.A191V	PRICKLE4_uc003ord.2_RNA|TOMM6_uc003org.2_5'Flank|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	over-expressed breast tumor protein	151	LIM zinc-binding 2.					nucleus	zinc ion binding				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CGCTGCCCGGCTTGTGACCAG	0.602													4	28					0	0	0	0	T	41753268	T	T	41753268	3	4	229	1	0	0	0	0	1	0	0	0	12551	797	28	4	586	4	PRICKLE4	6	41753268	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08		41753268	129361799	31	41781											
C6orf170	221322	broad.mit.edu	37	chr6	121401926	121401926	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtctcatgatctatgtgctCtgcagtctaatgttccgcat	7	16	8	10	1	4	1	1	1	4	0	6	1	5	1	1	0	2	4	1	0	2	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr6:121401926C>G	uc003pyo.1	-	32	3833	c.3765G>C	c.(3763-3765)CAG>CAC	p.Q1255H		NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	1255					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		TCTATGTGCTCTGCAGTCTAA	0.378													6	41					0	0	0	0	G	121401926	G	G	121401926	3	3	229	1	0	0	0	0	1	0	0	0	2354	912	32	2	12	2	C6orf170	6	121401926	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	79648658	121401926	49713141	32	41782											
TIAM2	26230	broad.mit.edu	37	chr6	155450592	155450592	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccttacgcatcgagactcGgtggccccacatgcaaggtc	9	7	11	14	3	0	1	0	0	0	1	3	2	0	1	3	3	3	2	3	3	2	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr6:155450592G>A	uc003qqb.2	+	6	1508	c.235G>A	c.(235-237)GGT>AGT	p.G79S	TIAM2_uc003qqe.2_Missense_Mutation_p.G79S	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	79					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		ATCGAGACTCGGTGGCCCCAC	0.562													8	33					0	0	0	0	A	155450592	A	A	155450592	3	1	229	1	0	0	0	0	1	0	0	0	15957	1116	39	1	237	1	TIAM2	6	155450592	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	34048666	155450592	15664475	33	41783											
NOD1	10392	broad.mit.edu	37	chr7	30485828	30485828	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctccttcacttgttattttGttttttcccagtctgcagag	5	19	6	11	0	2	1	1	0	1	1	4	1	4	1	3	0	1	3	3	0	1	8			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr7:30485828G>A	uc003tav.2	-	9	2905	c.2382C>T	c.(2380-2382)AAC>AAT	p.N794N		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	794	LRR 5.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						TTGTTATTTTGTTTTTTCCCA	0.522													13	147					0	0	0	0	A	30485828	A	A	30485828	2	1	229	1	0	0	0	0	0	0	0	1	10570	1368	48	4		4	NOD1	7	30485828	Silent	SNP	G	TCGA-CV-7180-01A-11D-2012-08		30485828	128652835	34	41784											
CCDC132	55610	broad.mit.edu	37	chr7	92987685	92987685	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttgcctgggatcccatatCaataagaaagcaagacaaaa	17	8	8	8	0	1	2	1	0	0	2	2	3	2	3	2	1	2	2	2	1	7	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr7:92987685C>T	uc003umo.2	+	28	2960	c.2832C>T	c.(2830-2832)ATC>ATT	p.I944I	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Silent_p.I914I|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Silent_p.I664I	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	944											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			GATCCCATATCAATAAGAAAG	0.383													7	53					0	0	0	0	T	92987685	T	T	92987685	2	4	229	1	0	0	0	0	0	0	0	1	2779	816	29	2		2	CCDC132	7	92987685	Silent	SNP	C	TCGA-CV-7180-01A-11D-2012-08	62501857	92987685	66150978	35	41785											
CNTNAP2	26047	broad.mit.edu	37	chr7	146829390	146829390	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acggtgcctgtctttttcaaCgctacaagttacctggaggt	8	13	10	10	2	2	0	1	0	1	0	2	1	2	1	2	3	4	2	2	3	4	4	rs78543192	byFrequency	TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr7:146829390C>T	uc003weu.1	+	8	1653	c.1137C>T	c.(1135-1137)AAC>AAT	p.N379N		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	379	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCTTTTTCAACGCTACAAGTT	0.458										HNSCC(39;0.1)			12	89					0	0	0	0	T	146829390	T	T	146829390	2	4	229	1	0	0	0	0	0	0	0	1	3662	535	19	1		1	CNTNAP2	7	146829390	Silent	SNP	C	TCGA-CV-7180-01A-11D-2012-08	53841705	146829390	12309273	36	41786											
CSMD1	64478	broad.mit.edu	37	chr8	2796121	2796121	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagggctataccactgtacAgactgtgttcagagttgtgt	9	13	12	7	0	1	3	1	1	0	2	1	3	1	3	1	1	2	4	1	1	3	5			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr8:2796121A>G	uc011kwk.1	-	70	11074	c.10684T>C	c.(10684-10686)TGT>CGT	p.C3562R	CSMD1_uc011kwj.1_Missense_Mutation_p.C2876R|CSMD1_uc010lrg.2_Missense_Mutation_p.C1453R	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3562	Cytoplasmic (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACCACTGTACAGACTGTGTTC	0.468													5	19					0	0	0	0	G	2796121	G	G	2796121	3	3	229	1	0	0	0	0	1	0	0	0	3961	188	7	5	17	5	CSMD1	8	2796121	Missense_Mutation	SNP	A	TCGA-CV-7180-01A-11D-2012-08		2796121	143567901	37	41787											
SGK223	157285	broad.mit.edu	37	chr8	8185602	8185602	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagccgcctctgttgcccGccagccctgctgccggaagc	4	6	12	19	4	1	0	0	0	1	0	1	1	1	1	6	1	6	3	6	1	1	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr8:8185602G>A	uc003wsh.3	-	4	2690	c.2690C>T	c.(2689-2691)GCG>GTG	p.A897V		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	897							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TCTGTTGCCCGCCAGCCCTGC	0.662													31	139					0	0	0	0	A	8185602	A	A	8185602	3	1	229	1	0	0	0	0	1	0	0	0	14275	1087	38	1	1526	1	SGK223	8	8185602	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	5389481	8185602	138178420	38	41788											
FAM150A	389658	broad.mit.edu	37	chr8	53452412	53452412	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctggcgttgagcactcccTggtattgtaatagagtcggt	8	12	13	8	2	0	2	0	1	0	1	2	2	1	2	1	3	2	5	1	3	3	5			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr8:53452412T>C	uc003xrd.2	-	3	509	c.304A>G	c.(304-306)AGG>GGG	p.R102G	FAM150A_uc011ldt.1_Missense_Mutation_p.R102G	NM_207413	NP_997296	Q6UXT8	F150A_HUMAN	hypothetical protein LOC389658 precursor	102						extracellular region					0		Lung NSC(129;0.0919)|all_epithelial(80;0.125)|all_lung(136;0.17)				GAGCACTCCCTGGTATTGTAA	0.373													3	51					0	0	0	0	C	53452412	C	C	53452412	3	2	229	1	0	0	0	0	1	0	0	0	5484	1579	55	5	93	5	FAM150A	8	53452412	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	45266810	53452412	92911610	39	41789											
PLEC	5339	broad.mit.edu	37	chr8	144997709	144997709	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctgcagccgcctgtgcctGagcccgggcctgtgcctgct	2	9	13	17	2	1	1	0	1	1	0	1	1	1	1	6	1	6	2	6	1	0	0			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr8:144997709G>C	uc003zaf.1	-	31	6969	c.6799C>G	c.(6799-6801)CAG>GAG	p.Q2267E	PLEC_uc003zab.1_Missense_Mutation_p.Q2130E|PLEC_uc003zac.1_Missense_Mutation_p.Q2134E|PLEC_uc003zad.2_Missense_Mutation_p.Q2130E|PLEC_uc003zae.1_Missense_Mutation_p.Q2098E|PLEC_uc003zag.1_Missense_Mutation_p.Q2108E|PLEC_uc003zah.2_Missense_Mutation_p.Q2116E|PLEC_uc003zaj.2_Missense_Mutation_p.Q2157E	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2267	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCTGTGCCTGAGCCCGGGCC	0.746													3	25					0	0	0	0	C	144997709	C	C	144997709	3	2	229	1	0	0	0	0	1	0	0	0	12107	1299	45	2	7263	2	PLEC	8	144997709	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	91545297	144997709	1366313	40	41790											
CDKN2A	1029	broad.mit.edu	37	chr9	21974684	21974684	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accctctacccacctggatcGgcctccgaccgtaactattc	8	9	6	18	3	1	0	0	0	1	0	4	2	2	1	6	2	2	1	6	2	3	4			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr9:21974684G>A	uc003zpk.2	-	1	355	c.143C>T	c.(142-144)CCG>CTG	p.P48L	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Missense_Mutation_p.P48L|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	48	ANK 2.		P -> L (in CMM2 and a head and neck tumor; somatic mutation).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(25)|p.P48L(9)|p.P48P(1)|p.P48R(1)|p.V28_V51del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CACCTGGATCGGCCTCCGACC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			53	141					0	0	0	0	A	21974684	A	A	21974684	3	1	229	1	0	0	0	0	1	0	0	0	3176	1116	39	1	540	1	CDKN2A	9	21974684	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08		21974684	119238747	41	41791											
LINGO2	158038	broad.mit.edu	37	chr9	27949442	27949442	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttcttttcacggattttggGttttttgcaggtaaagtaaa	9	18	9	5	1	2	0	1	0	1	0	2	1	2	1	0	3	1	4	0	3	4	10			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr9:27949442G>T	uc003zqu.1	-	2	1422	c.1228C>A	c.(1228-1230)CCC>ACC	p.P410T	LINGO2_uc010mjf.1_Missense_Mutation_p.P410T|LINGO2_uc003zqv.1_Missense_Mutation_p.P410T	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	410	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CGGATTTTGGGTTTTTTGCAG	0.488													12	50					3.07112e-06	3.76577e-06	1	0	T	27949442	T	T	27949442	3	4	229	1	0	0	0	0	1	0	0	0	8857	1261	44	4	596	4	LINGO2	9	27949442	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	5974758	27949442	113263989	42	41792											
PHF2	5253	broad.mit.edu	37	chr9	96418259	96418259	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgtggactgcctggccttCgcgggacatttcctccacag	5	10	11	15	2	0	0	0	0	0	0	3	2	2	2	5	3	1	0	5	3	0	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr9:96418259C>T	uc004aub.2	+	8	1143	c.996C>T	c.(994-996)TTC>TTT	p.F332F	PHF2_uc011lug.1_Silent_p.F215F	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	332	JmjC.				liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		GCCTGGCCTTCGCGGGACATT	0.637													3	16					0	0	0	0	T	96418259	T	T	96418259	2	4	229	1	0	0	0	0	0	0	0	1	11885	883	31	1		1	PHF2	9	96418259	Silent	SNP	C	TCGA-CV-7180-01A-11D-2012-08	68468817	96418259	44795172	43	41793											
SLC44A1	23446	broad.mit.edu	37	chr9	108097866	108097866	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtattctttttggatccaTgcaacctggacttgataaac	11	15	7	8	0	1	1	0	1	1	0	2	3	2	3	2	2	3	2	2	2	4	6			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr9:108097866T>C	uc004bcn.2	+	4	513	c.292T>C	c.(292-294)TGC>CGC	p.C98R	SLC44A1_uc010mtk.1_Missense_Mutation_p.C98R	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	98	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	TTTGGATCCATGCAACCTGGA	0.403													9	81					0	0	0	0	C	108097866	C	C	108097866	3	2	229	1	0	0	0	0	1	0	0	0	14699	1464	51	5	306	5	SLC44A1	9	108097866	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	11679607	108097866	33115565	44	41794											
ZNF22	7570	broad.mit.edu	37	chr10	45498926	45498926	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcagaagtggggcatgactaTtcgatttgactcaagcttca	11	11	11	8	1	2	3	2	2	0	1	3	4	2	3	0	2	1	3	0	2	3	4			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr10:45498926T>C	uc001jbw.2	+	2	353	c.110T>C	c.(109-111)ATT>ACT	p.I37T	C10orf25_uc010qff.1_5'Flank|C10orf25_uc001jbv.1_5'Flank|uc001jbx.1_RNA	NM_006963	NP_008894	P17026	ZNF22_HUMAN	zinc finger protein 22 (KOX 15)	37					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			breast(1)|kidney(1)	2		Prostate(175;0.0352)|all_neural(218;0.202)				GGCATGACTATTCGATTTGAC	0.463													14	52					0	0	0	0	C	45498926	C	C	45498926	3	2	229	1	0	0	0	0	1	0	0	0	17841	1493	52	5	112	5	ZNF22	10	45498926	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08		45498926	90035821	45	41795											
DYDC2	84332	broad.mit.edu	37	chr10	82126492	82126492	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agaagaccatattcatgcagGaggacacaaacccccttgag	15	6	9	11	0	1	3	1	1	0	2	1	5	1	5	3	2	2	1	3	2	3	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr10:82126492G>A	uc001kca.1	+	5	699	c.319G>A	c.(319-321)GAG>AAG	p.E107K	DYDC2_uc001kbz.1_RNA|DYDC2_uc001kcb.1_Missense_Mutation_p.E107K	NM_032372	NP_115748	Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	107							protein binding				0			Colorectal(32;0.229)			ATTCATGCAGGAGGACACAAA	0.438													33	115					0	0	0	0	A	82126492	A	A	82126492	3	1	229	1	0	0	0	0	1	0	0	0	4861	1175	41	2	329	2	DYDC2	10	82126492	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	36627566	82126492	53408255	46	41796											
HELLS	3070	broad.mit.edu	37	chr10	96350210	96350210	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctactggtcgaccaaaacGacgaactagaaaatcaataa	18	7	6	10	3	1	1	1	0	0	1	3	4	2	1	2	1	3	0	2	1	9	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr10:96350210G>T	uc001kjt.2	+	14	1634	c.1529G>T	c.(1528-1530)CGA>CTA	p.R510L	HELLS_uc001kjs.2_Missense_Mutation_p.R494L|HELLS_uc009xul.2_Missense_Mutation_p.R412L|HELLS_uc009xum.2_Missense_Mutation_p.R380L|HELLS_uc009xun.2_Missense_Mutation_p.R386L|HELLS_uc009xuo.2_Missense_Mutation_p.R556L|HELLS_uc001kju.2_Missense_Mutation_p.R149L|HELLS_uc009xup.2_RNA|HELLS_uc009xuq.2_Missense_Mutation_p.R372L|HELLS_uc009xur.2_RNA	NM_018063	NP_060533	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	510					cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		CGACCAAAACGACGAACTAGA	0.343													12	46					2.27111e-07	2.81837e-07	1	0	T	96350210	T	T	96350210	3	4	229	1	0	0	0	0	1	0	0	0	7085	1058	37	3	1583	3	HELLS	10	96350210	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	14223718	96350210	39184537	47	41797											
PTPRE	5791	broad.mit.edu	37	chr10	129839235	129839235	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagaccactgccgacagcaaCgagacaaccacgacctcagg	14	2	10	15	3	1	2	1	0	0	2	1	6	1	2	4	1	4	1	4	1	2	0	rs144835853		TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr10:129839235C>T	uc001lkb.2	+	3	369	c.90C>T	c.(88-90)AAC>AAT	p.N30N	PTPRE_uc009yat.2_Silent_p.N41N|PTPRE_uc010qup.1_RNA|PTPRE_uc009yau.2_Silent_p.N30N|PTPRE_uc001lkc.1_RNA	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	30	Extracellular (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				CCGACAGCAACGAGACAACCA	0.607													4	23					0	0	0	0	T	129839235	T	T	129839235	2	4	229	1	0	0	0	0	0	0	0	1	12865	535	19	1		1	PTPRE	10	129839235	Silent	SNP	C	TCGA-CV-7180-01A-11D-2012-08	33489025	129839235	5695512	48	41798											
LGR4	55366	broad.mit.edu	37	chr11	27395209	27395209	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taggaaaggaagttaattcaTtgaaacttacatctctaaaa	18	12	6	5	0	2	1	1	1	1	0	3	3	2	3	0	2	2	1	0	2	8	6			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr11:27395209T>A	uc001mrj.3	-	15	1753	c.1268A>T	c.(1267-1269)AAT>ATT	p.N423I	LGR4_uc001mrk.3_Missense_Mutation_p.N399I	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	423	LRR 15.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						AGTTAATTCATTGAAACTTAC	0.333													18	25					0	0	0	0	A	27395209	A	A	27395209	3	1	229	1	0	0	0	0	1	0	0	0	8797	1493	52	5	1603	5	LGR4	11	27395209	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08		27395209	107611307	49	41799											
OR4D10	390197	broad.mit.edu	37	chr11	59245249	59245249	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtggatgtattttctctttCggtgatggcattggatcgat	6	17	13	5	2	1	1	0	1	1	0	4	4	1	3	0	5	0	2	0	5	1	5			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr11:59245249C>T	uc001nnz.1	+	1	347	c.347C>T	c.(346-348)TCG>TTG	p.S116L		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TTTTCTCTTTCGGTGATGGCA	0.478													25	68					0	0	0	0	T	59245249	T	T	59245249	3	4	229	1	0	0	0	0	1	0	0	0	11108	893	31	1	349	1	OR4D10	11	59245249	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	31850040	59245249	75761267	50	41800											
FAM118B	79607	broad.mit.edu	37	chr11	126126642	126126642	+	Frame_Shift_Del	DEL	A	-	-																															tcaaaaagcttcgagaaaacAtgctggacaaggggattaaa																										TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr11:126126642delA	uc001qdf.2	+	7	1060	c.877delA	c.(877-879)ATGfs	p.M293fs	FAM118B_uc009zca.2_Frame_Shift_Del_p.M297fs|FAM118B_uc001qdg.2_Frame_Shift_Del_p.M293fs	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	293											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		TCGAGAAAACATGCTGGACAA	0.453													---	---	---								-	126126642	-	-	126126642	7	5	229	1	0	1	0	1	0	0	0	0	5440	217	8	0	895	0	FAM118B	11	126126642	Frame_Shift_Del	DEL	A	TCGA-CV-7180-01A-11D-2012-08	66881393	126126642	8879874	51	41801											
ADAMTS8	11095	broad.mit.edu	37	chr11	130275560	130275560	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccctgcactctacagttcGcctctgccagccggccccgc	4	8	9	20	3	2	0	0	0	2	0	4	0	3	0	6	1	4	2	6	1	1	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr11:130275560G>A	uc001qgg.3	-	9	2921	c.2563C>T	c.(2563-2565)CGA>TGA	p.R855*	ADAMTS8_uc001qgf.2_Nonsense_Mutation_p.R336*	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	855	TSP type-1 2.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TCTACAGTTCGCCTCTGCCAG	0.652													5	86					0	0	0	0	A	130275560	A	A	130275560	4	1	229	1	0	0	0	0	0	1	0	0	272	1095	38	1	110	1	ADAMTS8	11	130275560	Nonsense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	4148918	130275560	4730956	52	41802											
SRGAP1	57522	broad.mit.edu	37	chr12	64456755	64456755	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctaagaacatatctgtctgCggagtacaaccttgaaacct	13	10	7	11	1	2	2	0	1	2	1	2	3	2	3	3	1	5	1	3	1	6	4			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr12:64456755C>G	uc010ssp.1	+	7	916	c.860C>G	c.(859-861)GCG>GGG	p.A287G	SRGAP1_uc001srt.2_Missense_Mutation_p.A287G|SRGAP1_uc001srv.2_Missense_Mutation_p.A247G	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	287					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		TATCTGTCTGCGGAGTACAAC	0.373													7	30					0	0	0	0	G	64456755	G	G	64456755	3	3	229	1	0	0	0	0	1	0	0	0	15211	768	27	3	886	3	SRGAP1	12	64456755	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08		64456755	69395140	53	41803											
ACACB	32	broad.mit.edu	37	chr12	109696115	109696115	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtgattgctgtggagacacgGactgtggaggtggcagtccc	7	9	17	8	1	0	2	0	1	0	1	1	5	1	4	1	5	1	2	1	5	0	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr12:109696115G>T	uc001tob.2	+	46	6425	c.6306G>T	c.(6304-6306)CGG>CGT	p.R2102R	ACACB_uc001toc.2_Silent_p.R2102R|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.R768R	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2102	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TGGAGACACGGACTGTGGAGG	0.632													9	32					2.17888e-05	2.64029e-05	1	0	T	109696115	T	T	109696115	2	4	229	1	0	0	0	0	0	0	0	1	107	1161	41	2		2	ACACB	12	109696115	Silent	SNP	G	TCGA-CV-7180-01A-11D-2012-08	45239360	109696115	24155780	54	41804											
MED13L	23389	broad.mit.edu	37	chr12	116408480	116408480	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgttgggaacaccaagaTgtgtgtacaagaagcatctt	13	11	11	6	0	1	3	0	1	1	2	1	4	1	4	1	1	3	3	1	1	5	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr12:116408480T>C	uc001tvw.2	-	27	6041	c.5986A>G	c.(5986-5988)ATC>GTC	p.I1996V		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1996					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		AACACCAAGATGTGTGTACAA	0.478													11	47					0	0	0	0	C	116408480	C	C	116408480	3	2	229	1	0	0	0	0	1	0	0	0	9484	1464	51	5	666	5	MED13L	12	116408480	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	6712365	116408480	17443415	55	41805											
SPATA13	221178	broad.mit.edu	37	chr13	24876816	24876816	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcactatgcccacaagcGtcccccagcagcaggtcttt	10	8	7	16	1	2	0	1	0	1	0	3	0	3	0	3	1	4	2	3	1	2	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr13:24876816G>A	uc001upg.1	+	12	2271	c.1864G>A	c.(1864-1866)GTC>ATC	p.V622I	SPATA13_uc001upd.1_Missense_Mutation_p.V1247I|C1QTNF9_uc001upe.2_Intron|SPATA13_uc010tcy.1_Missense_Mutation_p.R569H|SPATA13_uc010tcz.1_Missense_Mutation_p.V506I|SPATA13_uc010tda.1_Missense_Mutation_p.V566I|SPATA13_uc001uph.2_Missense_Mutation_p.V544I|SPATA13_uc010tdb.1_Missense_Mutation_p.V482I|SPATA13_uc009zzz.1_Missense_Mutation_p.R179H	NM_153023	NP_694568	Q96N96	SPT13_HUMAN	spermatogenesis associated 13	622	C-terminal tail.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GCCCACAAGCGTCCCCCAGCA	0.622													29	102					0	0	0	0	A	24876816	A	A	24876816	3	1	229	1	0	0	0	0	1	0	0	0	15066	1145	40	1	3785	1	SPATA13	13	24876816	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08		24876816	90293062	56	41806											
DOCK9	23348	broad.mit.edu	37	chr13	99449739	99449739	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catatgctagtgggccagcaTtgacctagacaaagagcaaa	15	7	10	9	0	0	3	0	1	0	2	0	3	0	3	2	1	3	3	2	1	5	4			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr13:99449739T>C	uc001vnt.2	-	53	6021	c.5966A>G	c.(5965-5967)AAT>AGT	p.N1989S	DOCK9_uc001vnw.2_Missense_Mutation_p.N1988S|DOCK9_uc001vnq.2_Missense_Mutation_p.N536S|DOCK9_uc001vnr.2_Missense_Mutation_p.N618S|DOCK9_uc010tin.1_Missense_Mutation_p.N607S|DOCK9_uc001vns.2_Missense_Mutation_p.N524S|DOCK9_uc010tio.1_Missense_Mutation_p.N644S|DOCK9_uc010tip.1_Missense_Mutation_p.N685S	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1989	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGGGCCAGCATTGACCTAGAC	0.428													4	18					0	0	0	0	C	99449739	C	C	99449739	3	2	229	1	0	0	0	0	1	0	0	0	4716	1493	52	5	259	5	DOCK9	13	99449739	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	74572923	99449739	15720139	57	41807											
MNAT1	4331	broad.mit.edu	37	chr14	61201602	61201602	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggacgatcagggttgccctCggtgtaagaccaccaaatat	11	9	11	10	2	1	1	1	0	0	1	2	3	1	2	3	3	1	2	3	3	3	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr14:61201602C>T	uc001xfd.2	+	1	133	c.22C>T	c.(22-24)CGG>TGG	p.R8W	MNAT1_uc010apq.1_Missense_Mutation_p.R8W|MNAT1_uc001xfe.2_Missense_Mutation_p.R8W	NM_002431	NP_002422	P51948	MAT1_HUMAN	menage a trois 1 (CAK assembly factor)	8	RING-type.				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein complex assembly|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cytoplasm|holo TFIIH complex	protein N-terminus binding|zinc ion binding			ovary(1)|lung(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.0174)		GGGTTGCCCTCGGTGTAAGAC	0.592								Direct_reversal_of_damage|NER					6	65					0	0	0	0	T	61201602	T	T	61201602	3	4	229	1	0	0	0	0	1	0	0	0	9727	875	31	1	24	1	MNAT1	14	61201602	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08		61201602	46147938	58	41808											
EIF2B2	8892	broad.mit.edu	37	chr14	75469994	75469994	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaggggagctgatggagctGatccgcagagagggcaggag	10	5	20	6	1	0	3	0	2	0	1	1	7	1	6	1	5	2	5	1	5	1	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr14:75469994G>T	uc001xrc.1	+	2	262	c.180G>T	c.(178-180)CTG>CTT	p.L60L		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	60					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		TGATGGAGCTGATCCGCAGAG	0.582													8	23					1.06961e-07	1.34354e-07	1	0	T	75469994	T	T	75469994	2	4	229	1	0	0	0	0	0	0	0	1	5023	1277	45	2		2	EIF2B2	14	75469994	Silent	SNP	G	TCGA-CV-7180-01A-11D-2012-08	14268392	75469994	31879546	59	41809											
LCMT2	9836	broad.mit.edu	37	chr15	43622318	43622318	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcgtctctccaatcctttCtgctttgcgccgcgccacgt	3	13	9	16	5	2	0	0	0	2	0	5	0	4	0	4	1	2	1	4	1	1	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr15:43622318C>G	uc001zrg.2	-	1	574	c.370G>C	c.(370-372)GAA>CAA	p.E124Q	LCMT2_uc010udn.1_Intron|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	124					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	CCAATCCTTTCTGCTTTGCGC	0.627													3	99					0	0	0	0	G	43622318	G	G	43622318	3	3	229	1	0	0	0	0	1	0	0	0	8719	922	32	2	1694	2	LCMT2	15	43622318	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08		43622318	58909074	60	41810											
MTHFS	10588	broad.mit.edu	37	chr15	80181637	80181637	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttctgtctcaatttcatcTtgcatgctcagaaagatgga	10	15	7	9	0	6	2	3	0	4	2	7	3	6	3	0	1	2	2	0	1	2	3	rs142942013		TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr15:80181637T>C	uc002bex.3	-	2	217	c.177A>G	c.(175-177)CAA>CAG	p.Q59Q		NM_006441	NP_006432	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase	59					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding				0				all cancers(203;0.00467)		CAATTTCATCTTGCATGCTCA	0.398													12	61					0	0	0	0	C	80181637	C	C	80181637	2	2	229	1	0	0	0	0	0	0	0	1	9985	1606	56	5		5	MTHFS	15	80181637	Silent	SNP	T	TCGA-CV-7180-01A-11D-2012-08	36559319	80181637	22349755	61	41811											
C15orf42	90381	broad.mit.edu	37	chr15	90168446	90168446	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctcccacagcacacctggCaagagcagggggcaaaccta	12	4	10	15	0	1	1	0	0	1	1	2	1	1	1	3	3	3	4	3	3	3	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr15:90168446C>A	uc002boe.2	+	20	4905	c.4905C>A	c.(4903-4905)GGC>GGA	p.G1635G	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1635					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GCACACCTGGCAAGAGCAGGG	0.612													8	54					0.000274275	0.000321027	1	0	A	90168446	A	A	90168446	2	1	229	1	0	0	0	0	0	0	0	1	1802	697	25	4		4	C15orf42	15	90168446	Silent	SNP	C	TCGA-CV-7180-01A-11D-2012-08	9986809	90168446	12362946	62	41812											
PTX4	390667	broad.mit.edu	37	chr16	1537325	1537325	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtacttactctctcctGgcacctggggggaccatgcc	5	11	12	13	0	1	0	0	0	1	0	3	1	2	1	4	5	3	2	4	5	2	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr16:1537325G>C	uc010uvf.1	-	2	773	c.773C>G	c.(772-774)CCA>CGA	p.P258R		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	263						extracellular region	metal ion binding				0						ACTCTCTCCTGGCACCTGGGG	0.587													9	45					0	0	0	0	C	1537325	C	C	1537325	3	2	229	1	0	0	0	0	1	0	0	0	12888	1348	47	4	655	4	PTX4	16	1537325	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08		1537325	88817428	63	41813											
AARS	16	broad.mit.edu	37	chr16	70295032	70295032	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacataccctcctcggaccTgagcattcttcactgtaaac	10	10	6	15	1	2	1	1	1	1	0	4	2	3	2	3	1	3	3	3	1	3	4			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr16:70295032T>C	uc002eyn.1	-	13	1810	c.1700A>G	c.(1699-1701)CAG>CGG	p.Q567R	AARS_uc010vlu.1_Missense_Mutation_p.Q397R	NM_001605	NP_001596	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	567					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			pancreas(1)	1		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	TCCTCGGACCTGAGCATTCTT	0.398													3	70					0	0	0	0	C	70295032	C	C	70295032	3	2	229	1	0	0	0	0	1	0	0	0	19	1580	55	5	1242	5	AARS	16	70295032	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	68757707	70295032	20059721	64	41814											
ADAMTS18	170692	broad.mit.edu	37	chr16	77325275	77325275	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatttggtttcttaatattaCggcatcttcgctctgggaaa	9	16	9	7	2	3	0	0	0	3	0	4	2	3	1	0	3	1	3	0	3	4	6	rs150975249	byFrequency	TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr16:77325275C>T	uc002ffc.3	-	21	3709	c.3290G>A	c.(3289-3291)CGT>CAT	p.R1097H		NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1097	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CTTAATATTACGGCATCTTCG	0.502													23	234					0	0	0	0	T	77325275	T	T	77325275	3	4	229	1	0	0	0	0	1	0	0	0	263	536	19	1	387	1	ADAMTS18	16	77325275	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08	7030243	77325275	13029478	65	41815											
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	6	8	16	11	2	1	1	1	1	0	0	2	3	2	2	4	5	2	2	4	5	0	1	rs121912651		TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	33					0	0	0	0	A	7577539	A	A	7577539	3	1	229	1	0	0	0	0	1	0	0	0	16448	1115	39	1	548	1	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08		7577539	73617671	66	41816											
TMEM104	54868	broad.mit.edu	37	chr17	72791738	72791738	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	actgaccggtgctgggggccCctgcgccgagtggacgccta	5	6	16	14	4	0	1	0	1	0	0	0	3	0	2	5	4	2	1	5	4	1	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr17:72791738C>T	uc002jls.3	+	8	765	c.603C>T	c.(601-603)CCC>CCT	p.P201P	TMEM104_uc010wrf.1_Silent_p.P201P|TMEM104_uc010wrg.1_Silent_p.P214P|TMEM104_uc010dfx.2_Silent_p.P201P	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	201	Extracellular (Potential).					integral to membrane					0	all_lung(278;0.23)					GCTGGGGGCCCCTGCGCCGAG	0.607													9	30					0	0	0	0	T	72791738	T	T	72791738	2	4	229	1	0	0	0	0	0	0	0	1	16084	610	22	4		4	TMEM104	17	72791738	Silent	SNP	C	TCGA-CV-7180-01A-11D-2012-08	65214199	72791738	8403472	67	41817											
L3MBTL4	91133	broad.mit.edu	37	chr18	6264018	6264018	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcccaagaccatgctccCtgtgcagccgctgaagggac	9	6	10	16	1	0	2	0	1	0	1	2	3	2	3	4	1	3	3	4	1	2	0			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr18:6264018C>A	uc002kmz.3	-	5	307	c.147G>T	c.(145-147)CAG>CAT	p.Q49H	L3MBTL4_uc010dkt.2_Missense_Mutation_p.Q49H	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	49					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				ACCATGCTCCCTGTGCAGCCG	0.423													8	81					0.00448238	0.00507346	1	0	A	6264018	A	A	6264018	3	1	229	1	0	0	0	0	1	0	0	0	8634	680	24	4	1788	4	L3MBTL4	18	6264018	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08		6264018	71813230	68	41818											
ALPK2	115701	broad.mit.edu	37	chr18	56171233	56171233	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctggaaggtgcaacatttCtgaccagcttctgattctct	8	14	9	10	0	3	2	0	2	3	0	4	3	3	3	1	2	4	3	1	2	2	3			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr18:56171233C>T	uc002lhj.3	-	11	6391	c.6177G>A	c.(6175-6177)CAG>CAA	p.Q2059Q		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	2059	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TGCAACATTTCTGACCAGCTT	0.488													8	116					0	0	0	0	T	56171233	T	T	56171233	2	4	229	1	0	0	0	0	0	0	0	1	545	912	32	2		2	ALPK2	18	56171233	Silent	SNP	C	TCGA-CV-7180-01A-11D-2012-08	49907215	56171233	21906015	69	41819											
FZR1	51343	broad.mit.edu	37	chr19	3526259	3526259	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcttggtgcccgcagacGgcctggcctactctgccctg	3	10	13	15	2	1	1	0	0	1	1	1	1	1	1	4	3	4	2	4	3	1	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr19:3526259G>A	uc010dtk.2	+	4	296	c.262G>A	c.(262-264)GGC>AGC	p.G88S	FZR1_uc002lxt.2_Missense_Mutation_p.G88S|FZR1_uc002lxv.2_Missense_Mutation_p.G88S	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	88					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCGCAGACGGCCTGGCCTA	0.677													6	19					0	0	0	0	A	3526259	A	A	3526259	3	1	229	1	0	0	0	0	1	0	0	0	6172	1116	39	1	276	1	FZR1	19	3526259	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08		3526259	55602724	70	41820											
NCR1	9437	broad.mit.edu	37	chr19	55421380	55421380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttatctccttttccaggcGacattgagaacaccagcctt	9	13	6	13	1	1	1	0	1	1	1	3	3	2	1	4	1	2	0	4	1	2	6			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr19:55421380G>A	uc002qib.2	+	5	675	c.637G>A	c.(637-639)GAC>AAC	p.D213N	NCR1_uc002qic.2_Missense_Mutation_p.D213N|NCR1_uc002qie.2_Missense_Mutation_p.D213N|NCR1_uc002qid.2_Missense_Mutation_p.D118N|NCR1_uc002qif.2_Missense_Mutation_p.D118N|NCR1_uc010esj.2_Missense_Mutation_p.D106N	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	213	Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		TTTTCCAGGCGACATTGAGAA	0.398													4	144					0	0	0	0	A	55421380	A	A	55421380	3	1	229	1	0	0	0	0	1	0	0	0	10291	1058	37	1	655	1	NCR1	19	55421380	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	51895121	55421380	3707603	71	41821											
ZNF324	25799	broad.mit.edu	37	chr19	58983227	58983227	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcggcccttccgctgcgtGgactgtggcaaggccttcgc	4	8	15	14	4	0	0	0	0	0	0	2	2	1	1	3	4	2	2	3	4	1	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr19:58983227G>A	uc002qsw.1	+	4	1462	c.1368G>A	c.(1366-1368)GTG>GTA	p.V456V	ZNF324_uc002qsx.1_Silent_p.V233V	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	456	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TCCGCTGCGTGGACTGTGGCA	0.692													21	66					0	0	0	0	A	58983227	A	A	58983227	2	1	229	1	0	0	0	0	0	0	0	1	17911	1335	47	4		4	ZNF324	19	58983227	Silent	SNP	G	TCGA-CV-7180-01A-11D-2012-08	3561847	58983227	145756	72	41822											
MAVS	57506	broad.mit.edu	37	chr20	3845265	3845265	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccaagttgccaactagcTcaaagccccctggtgcagtg	9	8	9	15	0	1	0	1	0	0	0	2	0	2	0	5	1	5	3	5	1	4	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr20:3845265T>C	uc002wjw.3	+	6	1157	c.988T>C	c.(988-990)TCA>CCA	p.S330P	MAVS_uc002wjx.3_Missense_Mutation_p.S189P|MAVS_uc002wjy.3_Missense_Mutation_p.S28P	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	330	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						GCCAACTAGCTCAAAGCCCCC	0.552													4	113					0	0	0	0	C	3845265	C	C	3845265	3	2	229	1	0	0	0	0	1	0	0	0	9391	1551	54	5	1006	5	MAVS	20	3845265	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08		3845265	59180255	73	41823											
BMP2	650	broad.mit.edu	37	chr20	6758934	6758934	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacgagtgggaaaacaacccGgagattcttctttaatttaa	15	11	8	7	2	2	1	0	0	2	1	2	4	2	2	1	2	3	0	1	2	6	6			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr20:6758934G>T	uc002wmu.1	+	3	1174	c.389G>T	c.(388-390)CGG>CTG	p.R130L		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	130					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	AAAACAACCCGGAGATTCTTC	0.393													5	41					1.024e-07	1.30212e-07	1	0	T	6758934	T	T	6758934	3	4	229	1	0	0	0	0	1	0	0	0	1462	1116	39	3	395	3	BMP2	20	6758934	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08	2913669	6758934	56266586	74	41824											
ADRBK2	157	broad.mit.edu	37	chr22	26114347	26114347	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaggagagggagagtcccGggtaagtctaaggcagcctc	11	5	17	8	1	1	3	0	0	1	3	3	6	2	3	2	4	1	2	2	4	2	2			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chr22:26114347G>A	uc003abx.3	+	19	1937	c.1790G>A	c.(1789-1791)CGG>CAG	p.R597Q	ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	597	PH.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	GGAGAGTCCCGGGTAAGTCTA	0.453													13	72					0	0	0	0	A	26114347	A	A	26114347	3	1	229	1	0	0	0	0	1	0	0	0	344	1130	39	1	1864	1	ADRBK2	22	26114347	Missense_Mutation	SNP	G	TCGA-CV-7180-01A-11D-2012-08		26114347	25190219	75	41825											
ZCCHC5	203430	broad.mit.edu	37	chrX	77913257	77913257	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcctgtggaaactctgaagCtgctgatgtctccacaacta	10	10	10	11	0	2	2	0	2	2	0	3	3	2	3	2	2	4	2	2	2	4	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chrX:77913257C>A	uc004edc.1	-	2	957	c.661G>T	c.(661-663)GCT>TCT	p.A221S		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	221							nucleic acid binding|zinc ion binding			ovary(1)	1						AACTCTGAAGCTGCTGATGTC	0.517													5	26					0.000602214	0.000696945	1	0	A	77913257	A	A	77913257	3	1	229	1	0	0	0	0	1	0	0	0	17658	797	28	4	770	4	ZCCHC5	23	77913257	Missense_Mutation	SNP	C	TCGA-CV-7180-01A-11D-2012-08		77913257	77357303	76	41826											
FMR1NB	158521	broad.mit.edu	37	chrX	147084786	147084786	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaaaatgctcatggccaaTctctggaagaagattccgca	13	9	10	9	1	2	3	1	1	1	2	4	4	3	4	2	2	1	2	2	2	5	1			TCGA-CV-7180-01A-11D-2012-08	TCGA-CV-7180-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4233a363-ba28-495c-8590-644199c33d64	06b27da1-e2ad-4177-ba32-e23374a18309	g.chrX:147084786T>A	uc004fcm.2	+	2	417	c.343T>A	c.(343-345)TCT>ACT	p.S115T		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	115	Extracellular (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCATGGCCAATCTCTGGAAGA	0.363													23	40					0	0	0	0	A	147084786	A	A	147084786	3	1	229	1	0	0	0	0	1	0	0	0	5993	1435	50	5	349	5	FMR1NB	23	147084786	Missense_Mutation	SNP	T	TCGA-CV-7180-01A-11D-2012-08	69171529	147084786	8185774	77	41827											
AJAP1	55966	broad.mit.edu	37	chr1	4829977	4829977	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggtcatagctgctctcatCacaactcttgtcttaaaaaa	13	13	5	10	0	5	0	3	0	3	0	6	0	5	0	0	1	3	2	0	1	5	3			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:4829977C>T	uc001alm.1	+	3	1275	c.894C>T	c.(892-894)ATC>ATT	p.I298I	AJAP1_uc001aln.2_Silent_p.I298I	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	298	Helical; Signal-anchor for type III membrane protein; (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CTGCTCTCATCACAACTCTTG	0.537													40	149					0	0	0	0	T	4829977	T	T	4829977	2	4	230	1	0	0	0	0	0	0	0	1	438	816	29	2		2	AJAP1	1	4829977	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08		4829977	244420644	1	41828											
EXTL1	2134	broad.mit.edu	37	chr1	26360245	26360245	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggatggtgggcttcctgaCgtcgagccatttctgggacg	5	10	16	10	4	1	1	0	1	1	0	3	4	2	3	2	4	1	1	2	4	0	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:26360245C>T	uc001blf.2	+	9	2444	c.1577C>T	c.(1576-1578)ACG>ATG	p.T526M		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	526	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		GGCTTCCTGACGTCGAGCCAT	0.582													36	94					0	0	0	0	T	26360245	T	T	26360245	3	4	230	1	0	0	0	0	1	0	0	0	5350	536	19	1	1611	1	EXTL1	1	26360245	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	21530268	26360245	222890376	2	41829											
WDTC1	23038	broad.mit.edu	37	chr1	27614251	27614252	+	Frame_Shift_Ins	INS	-	AT	AT																															acctgacagtaaaggagaccINSatccacatgtttggagacca																										TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:27614251_27614252insAT	uc009vst.2	+	6	913_914	c.378_379insAT	c.(376-381)ACCATCfs	p.T126fs	WDTC1_uc001bno.2_Frame_Shift_Ins_p.T126fs|WDTC1_uc001bnp.1_RNA	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	126_127	WD 2.						protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		TAAAGGAGACCATCCACATGTT	0.564													---	---	---								AT	27614252	AT	AT	27614251	7	5	230	1	0	1	1	0	0	0	0	0	17410	581	21	0	396	0	WDTC1	1	27614251	Frame_Shift_Ins	INS	-	TCGA-CV-7183-01A-11D-2012-08	1254006	27614251	221636370	3	41830											
MACF1	23499	broad.mit.edu	37	chr1	39908232	39908232	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattgaagttgagctcgcaaAgcaccatgtaagtattttca	13	12	8	8	1	1	2	1	2	0	0	2	2	1	2	1	0	2	6	1	0	4	6			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:39908232A>T	uc010oiu.1	+	42	14557	c.14426A>T	c.(14425-14427)AAG>ATG	p.K4809M	MACF1_uc010ois.1_Missense_Mutation_p.K4307M	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAGCTCGCAAAGCACCATGTA	0.403													24	39					0	0	0	0	T	39908232	T	T	39908232	3	4	230	1	0	0	0	0	1	0	0	0	9195	72	3	5	19361	5	MACF1	1	39908232	Missense_Mutation	SNP	A	TCGA-CV-7183-01A-11D-2012-08	12293981	39908232	209342389	4	41831											
CRNN	49860	broad.mit.edu	37	chr1	152383314	152383314	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttgaaacaggcctgggCaactttaaacactaagacca	14	9	8	10	0	1	2	0	1	1	1	1	2	1	2	2	2	3	1	2	2	5	4			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:152383314C>A	uc001ezx.2	-	3	318	c.244G>T	c.(244-246)GCC>TCC	p.A82S		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	82	EF-hand.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGGCCTGGGCAACTTTAAAC	0.567													22	128					0.000175454	0.000203054	1	0	A	152383314	A	A	152383314	3	1	230	1	0	0	0	0	1	0	0	0	3907	710	25	4	1247	4	CRNN	1	152383314	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	112475082	152383314	96867307	5	41832											
CD48	962	broad.mit.edu	37	chr1	160650998	160650998	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggatccttcttacccagggTacagggtggactgaggcaga	9	8	15	9	0	1	2	0	1	1	1	2	4	2	4	2	5	2	2	2	5	2	3			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:160650998T>C	uc001fwn.2	-	3	678	c.646A>G	c.(646-648)ACC>GCC	p.T216A	CD48_uc001fwo.1_Missense_Mutation_p.T216A	NM_001778	NP_001769	P09326	CD48_HUMAN	CD48 molecule precursor	216					blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding				0	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TTACCCAGGGTACAGGGTGGA	0.522													13	51					0	0	0	0	C	160650998	C	C	160650998	3	2	230	1	0	0	0	0	1	0	0	0	3035	1638	57	5	93	5	CD48	1	160650998	Missense_Mutation	SNP	T	TCGA-CV-7183-01A-11D-2012-08	8267684	160650998	88599623	6	41833											
PAPPA2	60676	broad.mit.edu	37	chr1	176738863	176738863	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caaacttctcctgctcagagGgaaccaaatttctgaaacgc	13	9	7	12	1	3	2	1	1	2	1	4	3	3	3	2	1	4	1	2	1	4	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:176738863G>A	uc001gkz.2	+	16	5608	c.4444G>A	c.(4444-4446)GGA>AGA	p.G1482R	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1482	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CTGCTCAGAGGGAACCAAATT	0.522													15	139					0	0	0	0	A	176738863	A	A	176738863	3	1	230	1	0	0	0	0	1	0	0	0	11487	1233	43	4	4555	4	PAPPA2	1	176738863	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	16087865	176738863	72511758	7	41834											
PIGR	5284	broad.mit.edu	37	chr1	207109003	207109003	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tactgggccttaacccacccCtcgctgtccaccagcagggg	7	7	10	17	1	0	0	0	0	0	0	2	0	1	0	6	3	3	2	6	3	2	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:207109003C>T	uc001hez.2	-	5	1390	c.1206G>A	c.(1204-1206)GAG>GAA	p.E402E	PIGR_uc009xbz.2_Silent_p.E402E	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	402	Ig-like V-type 4.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TAACCCACCCCTCGCTGTCCA	0.627											OREG0014186	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	37					0	0	0	0	T	207109003	T	T	207109003	2	4	230	1	0	0	0	0	0	0	0	1	11952	680	24	4		4	PIGR	1	207109003	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08	30370140	207109003	42141618	8	41835											
YOD1	55432	broad.mit.edu	37	chr1	207222672	207222672	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatcttccccaaaacgaTcaattcttactgtctgtgta	10	14	5	12	1	4	0	1	0	3	0	5	1	5	0	2	0	3	2	2	0	5	4			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:207222672T>C	uc001hfe.1	-	2	787	c.740A>G	c.(739-741)GAT>GGT	p.D247G	PFKFB2_uc010psc.1_Intron|YOD1_uc001hff.1_Missense_Mutation_p.D203G	NM_018566	NP_061036	Q5VVQ6	OTU1_HUMAN	YOD1 OTU deubiquinating enzyme 1 homolog	247	OTU.				cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1	Prostate(682;0.19)					CCCAAAACGATCAATTCTTAC	0.403													47	119					0	0	0	0	C	207222672	C	C	207222672	3	2	230	1	0	0	0	0	1	0	0	0	17556	1435	50	5	310	5	YOD1	1	207222672	Missense_Mutation	SNP	T	TCGA-CV-7183-01A-11D-2012-08	113669	207222672	42027949	9	41836											
FH	2271	broad.mit.edu	37	chr1	241680611	241680611	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tctatccggaaggaattttgGcttgcctaaagacaagaata	14	11	9	7	1	1	2	0	0	1	2	2	4	2	4	2	3	1	1	2	3	8	6			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:241680611G>C	uc001hyx.2	-	2	170	c.138C>G	c.(136-138)AGC>AGG	p.S46R		NM_000143	NP_000134	P07954	FUMH_HUMAN	fumarate hydratase precursor	46					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		AGGAATTTTGGCTTGCCTAAA	0.378			Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				11	36					0	0	0	0	C	241680611	C	C	241680611	3	2	230	1	0	0	0	0	1	0	0	0	5907	1194	42	4	1430	4	FH	1	241680611	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	34457939	241680611	7570010	10	41837											
OR2T34	127068	broad.mit.edu	37	chr1	248737781	248737781	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acggggaaatggtatcatctCcagtgacctggcccacaagc	11	7	11	12	1	2	1	1	1	1	0	3	2	2	2	3	4	1	1	3	4	3	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr1:248737781C>T	uc001iep.1	-	1	278	c.278G>A	c.(277-279)GGA>GAA	p.G93E		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGTATCATCTCCAGTGACCTG	0.562													17	57					0	0	0	0	T	248737781	T	T	248737781	3	4	230	1	0	0	0	0	1	0	0	0	11079	855	30	2	682	2	OR2T34	1	248737781	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	7057170	248737781	512840	11	41838											
NBAS	51594	broad.mit.edu	37	chr2	15468389	15468389	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacccttgtttctctagatcTtcattggctgtagttccgat	6	17	7	11	1	3	1	1	0	2	1	5	2	4	1	2	1	0	4	2	1	2	7			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	450dc2ac-7819-416e-94ad-5017cf537354	g.chr2:15468389T>C	uc002rcc.1	-	37	4421	c.4395A>G	c.(4393-4395)GAA>GAG	p.E1465E	NBAS_uc010exl.1_Silent_p.E537E|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1465										ovary(2)|liver(1)|skin(1)	4						TCTCTAGATCTTCATTGGCTG	0.308													3	155					0	0	0	0	C	15468389	C	C	15468389	2	2	230	1	0	0	0	0	0	0	0	1	10239	1606	56	5		5	NBAS	2	15468389	Silent	SNP	T	TCGA-CV-7183-01A-11D-2012-08		15468389	227730984	12	41839											
HECW2	57520	broad.mit.edu	37	chr2	197183966	197183966	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctctgggccgccttcacCttcctctggggctgggcctg	2	10	14	15	1	3	0	1	0	2	0	4	0	4	0	5	5	0	2	5	5	0	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr2:197183966C>T	uc002utm.1	-	9	1831	c.1648G>A	c.(1648-1650)GGT>AGT	p.G550S	HECW2_uc002utl.1_Missense_Mutation_p.G194S	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	550					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CCGCCTTCACCTTCCTCTGGG	0.582													13	41					0	0	0	0	T	197183966	T	T	197183966	3	4	230	1	0	0	0	0	1	0	0	0	7082	681	24	4	3154	4	HECW2	2	197183966	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	181715577	197183966	46015407	13	41840											
KCNE4	23704	broad.mit.edu	37	chr2	223918016	223918016	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctcggagacgcccctcaaCgagagcagcgaagggtcctc	10	4	12	15	4	1	2	1	0	0	2	4	5	2	2	4	2	3	1	4	2	2	0			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr2:223918016C>T	uc002vnl.3	+	2	622	c.468C>T	c.(466-468)AAC>AAT	p.N156N		NM_080671	NP_542402	Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related	156	Cytoplasmic (Potential).					integral to membrane	voltage-gated potassium channel activity			ovary(1)	1		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		CGCCCCTCAACGAGAGCAGCG	0.627													10	40					0	0	0	0	T	223918016	T	T	223918016	2	4	230	1	0	0	0	0	0	0	0	1	8064	535	19	1		1	KCNE4	2	223918016	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08	26734050	223918016	19281357	14	41841											
ZNF860	344787	broad.mit.edu	37	chr3	32032156	32032156	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcaacccttgcacgtcatCatagacttcatactggagag	13	9	8	11	1	3	2	3	0	0	2	3	3	3	2	1	1	4	2	1	1	4	4			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr3:32032156C>T	uc011axg.1	+	2	2134	c.1585C>T	c.(1585-1587)CAT>TAT	p.H529Y		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	529	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGCACGTCATCATAGACTTCA	0.383													19	41					0	0	0	0	T	32032156	T	T	32032156	3	4	230	1	0	0	0	0	1	0	0	0	18261	826	29	2	1587	2	ZNF860	3	32032156	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08		32032156	165990274	15	41842											
PLXNA1	5361	broad.mit.edu	37	chr3	126733334	126733334	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcagctgtcccccgagaCgggcccgaggcagggcggca	6	3	15	17	4	1	1	1	0	0	1	2	3	2	1	4	4	1	3	4	4	0	0			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr3:126733334C>T	uc003ejg.2	+	12	2553	c.2549C>T	c.(2548-2550)ACG>ATG	p.T850M		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	873	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		TCCCCCGAGACGGGCCCGAGG	0.706													9	33					0	0	0	0	T	126733334	T	T	126733334	3	4	230	1	0	0	0	0	1	0	0	0	12174	536	19	1	2664	1	PLXNA1	3	126733334	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	94701178	126733334	71289096	16	41843											
LRRC15	131578	broad.mit.edu	37	chr3	194080356	194080356	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggacatggacgcttggaaCagcaacgttgacattgatga	12	8	14	7	2	0	3	0	3	0	0	0	6	0	6	0	4	3	3	0	4	2	3			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr3:194080356C>A	uc003ftu.2	-	2	1503	c.1417G>T	c.(1417-1419)GTT>TTT	p.V473F	LRRC15_uc003ftt.2_Missense_Mutation_p.V479F	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	473	LRRCT.|Extracellular (Potential).					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		ACGCTTGGAACAGCAACGTTG	0.542													6	25					8.12818e-05	9.51367e-05	1	0	A	194080356	A	A	194080356	3	1	230	1	0	0	0	0	1	0	0	0	9020	478	17	4	332	4	LRRC15	3	194080356	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	67347022	194080356	3942074	17	41844											
PDS5A	23244	broad.mit.edu	37	chr4	39978105	39978105	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtgatcttgtcggtgatCtcttttacccccggagggta	5	14	13	9	2	2	2	0	2	2	0	4	3	2	3	2	4	1	1	2	4	2	4			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr4:39978105C>T	uc003guv.3	-	2	633	c.93G>A	c.(91-93)GAG>GAA	p.E31E	PDS5A_uc010ifo.2_5'UTR|PDS5A_uc003guw.3_Silent_p.E31E	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	31					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						TGTCGGTGATCTCTTTTACCC	0.567											OREG0016159	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	107					0	0	0	0	T	39978105	T	T	39978105	2	4	230	1	0	0	0	0	0	0	0	1	11745	912	32	2		2	PDS5A	4	39978105	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08		39978105	151176171	18	41845											
HNRNPD	3184	broad.mit.edu	37	chr4	83280734	83280735	+	Frame_Shift_Ins	INS	-	C	C																															acttcaccaaatttggaaaaINSgtagtccttcagatctttct																										TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr4:83280734_83280735insC	uc003hmm.1	-	3	666_667	c.348_349insG	c.(346-351)TACTTTfs	p.Y116fs	HNRNPD_uc003hml.1_RNA|HNRNPD_uc003hmn.1_Frame_Shift_Ins_p.Y97fs|HNRNPD_uc003hmo.1_Frame_Shift_Ins_p.Y116fs|HNRNPD_uc003hmp.1_Frame_Shift_Ins_p.Y97fs|HNRNPD_uc010ijr.1_Frame_Shift_Ins_p.Y97fs|HNRNPD_uc011cci.1_Intron	NM_031370	NP_112738	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D	116_117	RRM 1.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding				0						AATTTGGAAAAGTAGTCCTTCA	0.376													---	---	---								C	83280735	C	C	83280734	7	5	230	1	0	1	1	0	0	0	0	0	7303	72	3	0	742	0	HNRNPD	4	83280734	Frame_Shift_Ins	INS	-	TCGA-CV-7183-01A-11D-2012-08	43302629	83280734	107873542	19	41846											
ALPK1	80216	broad.mit.edu	37	chr4	113347690	113347690	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatttggcacttcctcagccGgataaaaaggtggtttgtct	9	14	10	8	1	2	0	1	0	1	0	3	1	3	1	2	4	1	2	2	4	4	5			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr4:113347690G>T	uc003iap.3	+	8	969	c.690G>T	c.(688-690)CCG>CCT	p.P230P	ALPK1_uc003ian.3_Silent_p.P230P|ALPK1_uc011cfx.1_Silent_p.P152P|ALPK1_uc003iao.3_RNA|ALPK1_uc010imo.2_Silent_p.P58P	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	230							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TTCCTCAGCCGGATAAAAAGG	0.423													19	64					8.10497e-08	1.01806e-07	1	0	T	113347690	T	T	113347690	2	4	230	1	0	0	0	0	0	0	0	1	544	1103	39	3		3	ALPK1	4	113347690	Silent	SNP	G	TCGA-CV-7183-01A-11D-2012-08	30066956	113347690	77806586	20	41847											
FAT4	79633	broad.mit.edu	37	chr4	126373729	126373729	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttatgcaagtgtctgccagGatatgcgggtagctggtgtg	7	12	15	7	1	1	0	0	0	1	0	1	1	1	1	1	3	4	3	1	3	4	3			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr4:126373729G>T	uc003ifj.3	+	9	11558	c.11558G>T	c.(11557-11559)GGA>GTA	p.G3853V	FAT4_uc011cgp.1_Missense_Mutation_p.G2151V|FAT4_uc003ifi.1_Missense_Mutation_p.G1331V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3853	Extracellular (Potential).|EGF-like 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGTCTGCCAGGATATGCGGGT	0.463													11	46					7.03913e-09	8.95099e-09	1	0	T	126373729	T	T	126373729	3	4	230	1	0	0	0	0	1	0	0	0	5724	1174	41	2	11592	2	FAT4	4	126373729	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	13026039	126373729	64780547	21	41848											
PCDH10	57575	broad.mit.edu	37	chr4	134071537	134071537	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgaacgagaaaatagaccGcgaacaaatctgcaaacaga	19	4	9	9	4	1	4	0	1	1	3	1	6	1	4	1	0	4	1	1	0	7	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr4:134071537G>A	uc003iha.2	+	1	1068	c.242G>A	c.(241-243)CGC>CAC	p.R81H	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.R81H	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	81	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		AAAATAGACCGCGAACAAATC	0.567													27	90					0	0	0	0	A	134071537	A	A	134071537	3	1	230	1	0	0	0	0	1	0	0	0	11561	1087	38	1	244	1	PCDH10	4	134071537	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	7697808	134071537	57082739	22	41849											
SCOC	60592	broad.mit.edu	37	chr4	141300319	141300319	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caaggcccaaaagtttgttaCccaagatgatgaatgctgac	14	9	9	9	0	0	4	0	3	0	1	0	4	0	4	2	1	2	3	2	1	6	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr4:141300319C>A	uc003iif.2	+	2	253	c.226C>A	c.(226-228)CCC>ACC	p.P76T	SCOC_uc003iib.2_Missense_Mutation_p.P39T|SCOC_uc011che.1_Missense_Mutation_p.P39T|SCOC_uc003iid.2_Missense_Mutation_p.P39T|SCOC_uc011chf.1_Missense_Mutation_p.P39T|SCOC_uc011chg.1_Missense_Mutation_p.P39T|SCOC_uc011chh.1_Missense_Mutation_p.P76T|SCOC_uc003iig.2_Missense_Mutation_p.P76T	NM_001153484	NP_001146956	Q9UIL1	SCOC_HUMAN	short coiled-coil protein isoform 1	76						Golgi apparatus|nucleus	protein binding				0	all_hematologic(180;0.162)					AAGTTTGTTACCCAAGATGAT	0.343													23	113					5.61819e-17	7.51524e-17	1	0	A	141300319	A	A	141300319	3	1	230	1	0	0	0	0	1	0	0	0	13998	507	18	4	306	4	SCOC	4	141300319	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	7228782	141300319	49853957	23	41850											
ZNF827	152485	broad.mit.edu	37	chr4	146770712	146770712	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtttccttgtagctttcCgctgcaagtaggtgaatgaa	8	15	11	7	1	0	2	0	2	0	0	2	2	2	2	2	1	2	6	2	1	5	5			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr4:146770712C>T	uc003ikn.2	-	6	2031	c.1983G>A	c.(1981-1983)GCG>GCA	p.A661A	ZNF827_uc003ikm.2_Silent_p.A661A|ZNF827_uc010iox.2_Silent_p.A311A	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	661					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					TGTAGCTTTCCGCTGCAAGTA	0.438													21	84					0	0	0	0	T	146770712	T	T	146770712	2	4	230	1	0	0	0	0	0	0	0	1	18247	666	23	1		1	ZNF827	4	146770712	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08	5470393	146770712	44383564	24	41851											
FAT1	2195	broad.mit.edu	37	chr4	187629108	187629108	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattagcgatcgctttaatGacaatacccccgagttgggg	10	10	10	11	3	0	1	0	1	0	0	1	3	0	1	3	2	2	2	3	2	4	5			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr4:187629108G>T	uc003izf.2	-	2	2062	c.1874C>A	c.(1873-1875)TCA>TAA	p.S625*	FAT1_uc010iso.1_Nonsense_Mutation_p.S625*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	625	Extracellular (Potential).|Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TCGCTTTAATGACAATACCCC	0.408										HNSCC(5;0.00058)			18	45					1.00905e-13	1.33246e-13	1	0	T	187629108	T	T	187629108	4	4	230	1	0	0	0	0	0	1	0	0	5721	1294	45	2	11996	2	FAT1	4	187629108	Nonsense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	40858396	187629108	3525168	25	41852											
SDHA	6389	broad.mit.edu	37	chr5	225544	225544	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgtttccagggaggaatcaAtgctgctctggggaacatgg	9	10	15	7	0	2	0	1	0	1	0	3	3	3	3	1	5	3	3	1	5	3	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr5:225544A>G	uc003jao.3	+	4	438	c.323A>G	c.(322-324)AAT>AGT	p.N108S	SDHA_uc003jan.2_Missense_Mutation_p.N108S|SDHA_uc011clv.1_Missense_Mutation_p.N108S|SDHA_uc011clw.1_Intron|SDHA_uc003jap.3_Missense_Mutation_p.N108S|SDHA_uc003jaq.3_5'Flank	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	108					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	GGAGGAATCAATGCTGCTCTG	0.572									Familial_Paragangliomas				4	97					0	0	0	0	G	225544	G	G	225544	3	3	230	1	0	0	0	0	1	0	0	0	14028	101	4	5	337	5	SDHA	5	225544	Missense_Mutation	SNP	A	TCGA-CV-7183-01A-11D-2012-08		225544	180689716	26	41853											
PCDHA13	56136	broad.mit.edu	37	chr5	140263259	140263259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcgtgaaggaaaacaatcCgccgggctgccacatcttca	11	8	10	12	3	2	1	1	1	1	0	4	2	3	2	3	2	2	2	3	2	4	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr5:140263259C>T	uc003lif.2	+	1	1406	c.1406C>T	c.(1405-1407)CCG>CTG	p.P469L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.P469L|PCDHA13_uc003lid.2_Missense_Mutation_p.P469L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	469	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAACAATCCGCCGGGCTGC	0.677													44	121					0	0	0	0	T	140263259	T	T	140263259	3	4	230	1	0	0	0	0	1	0	0	0	11577	652	23	1	1408	1	PCDHA13	5	140263259	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	140037715	140263259	40652001	27	41854											
HAVCR2	84868	broad.mit.edu	37	chr5	156533761	156533761	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatggtcagggacacatctcCtttgcggaaatccccattta	10	12	8	11	1	2	0	1	0	1	0	4	2	3	2	3	3	1	0	3	3	3	4			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr5:156533761C>T	uc003lwk.1	-	2	415	c.271G>A	c.(271-273)GGA>AGA	p.G91R	HAVCR2_uc003lwl.2_Missense_Mutation_p.G91R	NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	91	Ig-like V-type.|Extracellular (Potential).					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GACACATCTCCTTTGCGGAAA	0.453													4	133					0	0	0	0	T	156533761	T	T	156533761	3	4	230	1	0	0	0	0	1	0	0	0	7013	690	24	4	658	4	HAVCR2	5	156533761	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	16270502	156533761	24381499	28	41855											
ODZ2	57451	broad.mit.edu	37	chr5	167545383	167545383	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggaaaggtgcagagtgcGacgtgcccatgaatcagtgc	10	7	15	9	2	1	2	1	1	0	1	1	4	1	3	1	2	4	2	1	2	2	0			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr5:167545383G>T	uc010jjd.2	+	10	1900	c.1900G>T	c.(1900-1902)GAC>TAC	p.D634Y	ODZ2_uc003lzq.2_Missense_Mutation_p.D513Y|ODZ2_uc003lzr.3_Missense_Mutation_p.D402Y|ODZ2_uc003lzt.3_5'UTR|uc003lzs.1_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TGCAGAGTGCGACGTGCCCAT	0.572													49	179					3.86236e-30	5.37599e-30	1	0	T	167545383	T	T	167545383	3	4	230	1	0	0	0	0	1	0	0	0	10889	1058	37	3	1938	3	ODZ2	5	167545383	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	11011622	167545383	13369877	29	41856											
DRD1	1812	broad.mit.edu	37	chr5	174869350	174869350	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttccggttgagaacattcGacaggctttccattacctgt	8	14	8	11	2	0	1	0	1	0	1	3	3	2	1	3	2	2	2	3	2	2	5	rs147169569		TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr5:174869350G>A	uc003mcz.2	-	2	1698	c.753C>T	c.(751-753)GTC>GTT	p.V251V		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	251	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	GAGAACATTCGACAGGCTTTC	0.478													26	82					0	0	0	0	A	174869350	A	A	174869350	2	1	230	1	0	0	0	0	0	0	0	1	4778	1045	37	1		1	DRD1	5	174869350	Silent	SNP	G	TCGA-CV-7183-01A-11D-2012-08	7323967	174869350	6045910	30	41857											
HIST1H3G	8355	broad.mit.edu	37	chr6	26271609	26271609	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcagtctgcttggtgcgggCcatctcagactacctgaaag	8	10	12	11	1	2	2	1	1	2	1	3	2	2	2	2	2	4	2	2	2	2	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr6:26271609C>A	uc003nhi.2	-	1	4	c.4G>T	c.(4-6)GCC>TCC	p.A2S	uc003nhj.2_5'Flank|HIST1H2BI_uc003nhk.2_5'Flank	NM_003534	NP_003525	P68431	H31_HUMAN	H3 histone family, member H	2					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						TTGGTGCGGGCCATCTCAGAC	0.552													11	44					3.86212e-05	4.62556e-05	1	0	A	26271609	A	A	26271609	3	1	230	1	0	0	0	0	1	0	0	0	7200	739	26	4	410	4	HIST1H3G	6	26271609	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08		26271609	144843458	31	41858											
KCNK5	8645	broad.mit.edu	37	chr6	39159505	39159505	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgaagtagcggtacagggCgtggtagttggcgctggggt	7	8	19	7	4	0	0	0	0	0	0	0	1	0	0	0	6	2	5	0	6	4	4			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr6:39159505C>A	uc003oon.2	-	5	1025	c.661G>T	c.(661-663)GCC>TCC	p.A221S		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	221					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						CGGTACAGGGCGTGGTAGTTG	0.567													42	109					6.5261e-18	8.96252e-18	1	0	A	39159505	A	A	39159505	3	1	230	1	0	0	0	0	1	0	0	0	8108	768	27	3	842	3	KCNK5	6	39159505	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	12887896	39159505	131955562	32	41859											
USP49	25862	broad.mit.edu	37	chr6	41774580	41774580	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcgtggtcctcaatatagcGgccgcaggccacgtgggagc	7	6	16	12	4	1	0	1	0	0	0	2	1	2	1	3	5	2	1	3	5	3	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr6:41774580G>A	uc003ori.2	-	4	364	c.142C>T	c.(142-144)CGC>TGC	p.R48C		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	48	UBP-type.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TCAATATAGCGGCCGCAGGCC	0.592													5	132					0	0	0	0	A	41774580	A	A	41774580	3	1	230	1	0	0	0	0	1	0	0	0	17148	1116	39	1	1796	1	USP49	6	41774580	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	2615075	41774580	129340487	33	41860											
KIAA0240	23506	broad.mit.edu	37	chr6	42796801	42796801	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tattaaagggcagcgggcagCaagccccatcaaatgtgagt	13	7	12	9	1	1	1	1	1	0	0	1	1	1	1	2	2	3	3	2	2	5	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr6:42796801C>T	uc003osn.1	+	6	881	c.730C>T	c.(730-732)CAA>TAA	p.Q244*	KIAA0240_uc003osm.1_Nonsense_Mutation_p.Q244*|KIAA0240_uc011duw.1_Nonsense_Mutation_p.Q244*|KIAA0240_uc003oso.1_Nonsense_Mutation_p.Q244*|KIAA0240_uc003osp.1_Nonsense_Mutation_p.Q244*	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	244										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			CAGCGGGCAGCAAGCCCCATC	0.448													16	47					0	0	0	0	T	42796801	T	T	42796801	4	4	230	1	0	0	0	0	0	1	0	0	8203	711	25	4	744	4	KIAA0240	6	42796801	Nonsense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	1022221	42796801	128318266	34	41861											
NR2E1	7101	broad.mit.edu	37	chr6	108508599	108508599	+	Frame_Shift_Del	DEL	A	-	-																															ctatagaagaagtgtttttcAaaaaaaccatcggcaatgtg																										TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr6:108508599delA	uc003psg.2	+	9	1845	c.1090delA	c.(1090-1092)AAAfs	p.K364fs		NM_003269	NP_003260	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	364	Required for transcriptional repression (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		AGTGTTTTTCAAAAAAACCAT	0.408													---	---	---								-	108508599	-	-	108508599	7	5	230	1	0	1	0	1	0	0	0	0	10679	131	5	0	1124	0	NR2E1	6	108508599	Frame_Shift_Del	DEL	A	TCGA-CV-7183-01A-11D-2012-08	65711798	108508599	62606468	35	41862											
CHRM2	1129	broad.mit.edu	37	chr7	136699801	136699801	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcaacaattactttttattCagcttggcctgtgctgacct	8	16	7	10	0	2	1	2	1	0	0	2	1	2	1	2	1	4	2	2	1	4	6			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr7:136699801C>T	uc003vtf.1	+	4	812	c.189C>T	c.(187-189)TTC>TTT	p.F63F	CHRM2_uc003vtg.1_Silent_p.F63F|CHRM2_uc003vtj.1_Silent_p.F63F|CHRM2_uc003vtk.1_Silent_p.F63F|CHRM2_uc003vtl.1_Silent_p.F63F|CHRM2_uc003vtm.1_Silent_p.F63F|CHRM2_uc003vti.1_Silent_p.F63F|CHRM2_uc003vto.1_Silent_p.F63F|CHRM2_uc003vtn.1_Silent_p.F63F|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	63	Helical; Name=2; (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ACTTTTTATTCAGCTTGGCCT	0.468													33	94					0	0	0	0	T	136699801	T	T	136699801	2	4	230	1	0	0	0	0	0	0	0	1	3392	825	29	2		2	CHRM2	7	136699801	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08		136699801	22438862	36	41863											
MCM4	4173	broad.mit.edu	37	chr8	48883929	48883929	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catctgtcagctcaatgcgcGcacctctgtcctggcagcag	7	9	10	15	2	4	0	2	0	2	0	5	0	5	0	2	1	3	4	2	1	1	0	rs151044076		TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr8:48883929G>T	uc003xqk.1	+	13	1924	c.1829G>T	c.(1828-1830)CGC>CTC	p.R610L	MCM4_uc003xql.1_Missense_Mutation_p.R610L|MCM4_uc011ldi.1_Missense_Mutation_p.R597L	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	610	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				CTCAATGCGCGCACCTCTGTC	0.493													7	32					0.000274275	0.000313893	1	0	T	48883929	T	T	48883929	3	4	230	1	0	0	0	0	1	0	0	0	9442	1087	38	3	1875	3	MCM4	8	48883929	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08		48883929	97480093	37	41864											
PKHD1L1	93035	broad.mit.edu	37	chr8	110503288	110503288	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgtatttgggacagatggaTtggacatagatgacaacatc	13	11	12	5	0	0	3	0	1	0	2	1	6	0	6	0	3	1	1	0	3	3	4			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr8:110503288T>A	uc003yne.2	+	61	10176	c.10072T>A	c.(10072-10074)TTG>ATG	p.L3358M		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3358	Extracellular (Potential).|PbH1 6.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GACAGATGGATTGGACATAGA	0.378										HNSCC(38;0.096)			26	58					0	0	0	0	A	110503288	A	A	110503288	3	1	230	1	0	0	0	0	1	0	0	0	12027	1490	52	5	10314	5	PKHD1L1	8	110503288	Missense_Mutation	SNP	T	TCGA-CV-7183-01A-11D-2012-08	61619359	110503288	35860734	38	41865											
FAM135B	51059	broad.mit.edu	37	chr8	139164609	139164609	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcactgggcaactccagagcCctgcttcgggcctctgacca	7	8	10	16	1	2	2	1	1	1	1	4	2	3	2	4	2	3	2	4	2	1	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr8:139164609C>A	uc003yuy.2	-	13	2280	c.2109G>T	c.(2107-2109)AGG>AGT	p.R703S	FAM135B_uc003yux.2_Missense_Mutation_p.R604S|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.R265S|FAM135B_uc003yvb.2_Missense_Mutation_p.R265S	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	703										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACTCCAGAGCCCTGCTTCGGG	0.547										HNSCC(54;0.14)			12	52					1.08611e-07	1.34782e-07	1	0	A	139164609	A	A	139164609	3	1	230	1	0	0	0	0	1	0	0	0	5477	622	22	4	2143	4	FAM135B	8	139164609	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	28661321	139164609	7199413	39	41866											
ARHGAP39	80728	broad.mit.edu	37	chr8	145771119	145771119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgtgaaagtggggaagaCgcagctggagctgggaacgc	11	4	18	8	3	0	2	0	1	0	1	0	5	0	5	0	4	4	3	0	4	3	0	rs141083413		TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr8:145771119C>T	uc003zdt.1	-	7	2590	c.2035G>A	c.(2035-2037)GTC>ATC	p.V679I	ARHGAP39_uc011llk.1_Missense_Mutation_p.V679I|ARHGAP39_uc003zds.1_Missense_Mutation_p.V679I	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	679					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						GTGGGGAAGACGCAGCTGGAG	0.647													9	40					0	0	0	0	T	145771119	T	T	145771119	3	4	230	1	0	0	0	0	1	0	0	0	884	536	19	1	1337	1	ARHGAP39	8	145771119	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	6606510	145771119	592903	40	41867											
UBAP1	51271	broad.mit.edu	37	chr9	34241766	34241766	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caactgtgaaaagatgtcacTgtcttccaaagtgtccctcc	11	11	7	12	0	2	2	1	1	1	1	5	2	5	2	3	0	1	0	3	0	4	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr9:34241766T>C	uc003ztx.2	+	4	978	c.743T>C	c.(742-744)CTG>CCG	p.L248P	UBAP1_uc010mka.1_Missense_Mutation_p.L284P|UBAP1_uc003zty.2_Missense_Mutation_p.L248P|UBAP1_uc011loi.1_Missense_Mutation_p.L284P|UBAP1_uc011loj.1_Missense_Mutation_p.L312P|KIF24_uc010mkb.2_Intron|UBAP1_uc003ztz.2_Missense_Mutation_p.L248P	NM_016525	NP_057609	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	248						cytoplasm					0			LUSC - Lung squamous cell carcinoma(29;0.00272)			AAGATGTCACTGTCTTCCAAA	0.468													18	34					0	0	0	0	C	34241766	C	C	34241766	3	2	230	1	0	0	0	0	1	0	0	0	16904	1580	55	5	990	5	UBAP1	9	34241766	Missense_Mutation	SNP	T	TCGA-CV-7183-01A-11D-2012-08		34241766	106971665	41	41868											
FGD3	89846	broad.mit.edu	37	chr9	95776270	95776270	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcaccccccaggaccgccAcctcttcctggtgagcctgg	5	6	11	19	2	1	1	0	1	1	0	2	2	2	2	8	4	1	1	8	4	0	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr9:95776270A>C	uc004asw.2	+	9	1800	c.1172A>C	c.(1171-1173)CAC>CCC	p.H391P	FGD3_uc004asx.2_Missense_Mutation_p.H391P|FGD3_uc004asz.2_Missense_Mutation_p.H391P|FGD3_uc004ata.2_Missense_Mutation_p.H194P|FGD3_uc011luc.1_5'Flank	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	391	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						CAGGACCGCCACCTCTTCCTG	0.632													10	109					0	0	0	0	C	95776270	C	C	95776270	3	2	230	1	0	0	0	0	1	0	0	0	5866	159	6	5	1198	5	FGD3	9	95776270	Missense_Mutation	SNP	A	TCGA-CV-7183-01A-11D-2012-08	61534504	95776270	45437161	42	41869											
CRB2	286204	broad.mit.edu	37	chr9	126133118	126133118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctgctgcctgaggatctcGgtgagaacgtcctcctgggc	5	10	13	13	2	1	2	0	2	1	1	5	4	4	3	4	3	3	1	4	3	1	0			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr9:126133118G>A	uc004bnx.1	+	7	1878	c.1786G>A	c.(1786-1788)GGT>AGT	p.G596S	CRB2_uc004bnw.1_Missense_Mutation_p.G596S	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	596	Extracellular (Potential).|Laminin G-like 1.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						TGAGGATCTCGGTGAGAACGT	0.652													3	68					0	0	0	0	A	126133118	A	A	126133118	3	1	230	1	0	0	0	0	1	0	0	0	3864	1116	39	1	1812	1	CRB2	9	126133118	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	30356848	126133118	15080313	43	41870											
FAM78A	286336	broad.mit.edu	37	chr9	134136553	134136553	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgctctcgctgacgggcaCggcccatgtgacgctggggt	4	9	16	12	4	1	2	0	2	1	0	2	2	1	2	1	4	1	5	1	4	0	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr9:134136553C>T	uc004cak.2	-	2	848	c.508G>A	c.(508-510)GTG>ATG	p.V170M	FAM78A_uc004caj.2_Missense_Mutation_p.V167M	NM_033387	NP_203745	Q5JUQ0	FA78A_HUMAN	hypothetical protein LOC286336	170										ovary(1)	1	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		CTGACGGGCACGGCCCATGTG	0.577													26	70					0	0	0	0	T	134136553	T	T	134136553	3	4	230	1	0	0	0	0	1	0	0	0	5658	536	19	1	347	1	FAM78A	9	134136553	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	8003435	134136553	7076878	44	41871											
SETX	23064	broad.mit.edu	37	chr9	135147149	135147149	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acacgtaacaataacacaatCcttctgccgaccctggaatg	14	8	6	13	2	1	0	0	0	1	0	2	2	2	1	3	1	3	1	3	1	5	3			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr9:135147149C>T	uc004cbk.2	-	24	7330	c.7147G>A	c.(7147-7149)GAT>AAT	p.D2383N	SETX_uc004cbj.2_Missense_Mutation_p.D2002N|SETX_uc010mzt.2_Intron	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2383					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ATAACACAATCCTTCTGCCGA	0.368													7	177					0	0	0	0	T	135147149	T	T	135147149	3	4	230	1	0	0	0	0	1	0	0	0	14206	855	30	2	898	2	SETX	9	135147149	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	1010596	135147149	6066282	45	41872											
C9orf96	169436	broad.mit.edu	37	chr9	136253278	136253278	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggagttcaatgagctcagCttccaggaggtcattgagga	11	10	13	7	0	3	2	3	2	0	0	4	5	4	5	1	4	2	3	1	4	1	3			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr9:136253278C>A	uc004cdk.2	+	5	403	c.342C>A	c.(340-342)AGC>AGA	p.S114R	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	114	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		ATGAGCTCAGCTTCCAGGAGG	0.567													20	63					5.49717e-05	6.50814e-05	1	0	A	136253278	A	A	136253278	3	1	230	1	0	0	0	0	1	0	0	0	2520	796	28	4	360	4	C9orf96	9	136253278	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	1106129	136253278	4960153	46	41873											
PRLHR	2834	broad.mit.edu	37	chr10	120353933	120353933	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaccagcaagcagaaggtgCgccggcgccgagcgcggtcc	8	2	15	16	6	0	1	0	0	0	1	1	2	1	1	5	3	4	2	5	3	2	0			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr10:120353933C>A	uc001ldp.1	-	2	963	c.824G>T	c.(823-825)CGC>CTC	p.R275L		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	275	Cytoplasmic (Potential).				female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GCAGAAGGTGCGCCGGCGCCG	0.687													7	25					2.0095e-06	2.43504e-06	1	0	A	120353933	A	A	120353933	3	1	230	1	0	0	0	0	1	0	0	0	12592	768	27	3	292	3	PRLHR	10	120353933	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08		120353933	15180814	47	41874											
HRAS	3265	broad.mit.edu	37	chr11	534289	534289	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcactcttgcccacaccgcCggcgcccaccaccaccagct	7	4	7	23	4	1	0	0	0	1	0	1	0	1	0	7	1	2	2	7	1	0	1	rs104894229		TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr11:534289C>A	uc001lpv.2	-	2	222	c.34G>T	c.(34-36)GGC>TGC	p.G12C	HRAS_uc010qvw.1_Missense_Mutation_p.G12C|HRAS_uc010qvx.1_Missense_Mutation_p.G12C|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	12	GTP.		G -> S (in FCSS, OSCC and CMEMS).|G -> E (in FCSS).|G -> C (in FCSS).|G -> A (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12V(250)|p.G12S(54)|p.G12D(39)|p.G12C(23)|p.G12R(12)|p.G12A(7)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CCCACACCGCCGGCGCCCACC	0.647		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			7	44					2.0095e-06	2.43504e-06	1	0	A	534289	A	A	534289	3	1	230	1	0	0	0	0	1	0	0	0	7387	652	23	3	618	3	HRAS	11	534289	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08		534289	134472227	48	41875											
MRVI1	10335	broad.mit.edu	37	chr11	10650331	10650331	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gactgtaagtgagttgctccGagaggatgtaggagaagcgc	11	8	16	6	2	0	3	0	1	0	2	1	7	1	4	1	2	2	4	1	2	3	3			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr11:10650331G>A	uc010rcc.1	-	6	1005	c.619C>T	c.(619-621)CGG>TGG	p.R207W	MRVI1_uc001miw.2_Missense_Mutation_p.R198W|MRVI1_uc010rcb.1_Missense_Mutation_p.R198W|MRVI1_uc009ygb.1_5'UTR|MRVI1_uc001mix.2_5'UTR|MRVI1_uc001miz.2_Missense_Mutation_p.R116W|MRVI1_uc009ygc.1_Missense_Mutation_p.R116W|MRVI1_uc010rcd.1_Missense_Mutation_p.R207W|MRVI1_uc009ygd.1_5'UTR|MRVI1_uc010rce.1_RNA	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	198					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		GAGTTGCTCCGAGAGGATGTA	0.597													4	2					0	0	0	0	A	10650331	A	A	10650331	3	1	230	1	0	0	0	0	1	0	0	0	9906	1057	37	1	2183	1	MRVI1	11	10650331	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	10116042	10650331	124356185	49	41876											
CAT	847	broad.mit.edu	37	chr11	34485744	34485744	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccaatattctggagaagtgCggagattcaacactgccaat	13	10	9	9	1	2	2	1	0	1	2	3	4	3	2	2	2	3	0	2	2	5	3	rs139875365	by1000genomes	TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr11:34485744C>T	uc001mvm.2	+	10	1371	c.1288C>T	c.(1288-1290)CGG>TGG	p.R430W	CAT_uc009ykc.1_RNA|CAT_uc001mvn.2_Missense_Mutation_p.R39W	NM_001752	NP_001743	P04040	CATA_HUMAN	catalase	430					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)	TGGAGAAGTGCGGAGATTCAA	0.463													25	77					0	0	0	0	T	34485744	T	T	34485744	3	4	230	1	0	0	0	0	1	0	0	0	2698	759	27	1	1326	1	CAT	11	34485744	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	23835413	34485744	100520772	50	41877											
FAT3	120114	broad.mit.edu	37	chr11	92615997	92615997	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttcctctgcaactgcacGccgggctacgtgggccagta	6	9	11	15	3	1	0	0	0	1	0	3	0	3	0	4	2	4	4	4	2	3	3			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	450dc2ac-7819-416e-94ad-5017cf537354	g.chr11:92615997G>T	uc001pdj.3	+	23	12392	c.12375G>T	c.(12373-12375)ACG>ACT	p.T4125T	FAT3_uc001pdi.3_Silent_p.T565T	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4125	Extracellular (Potential).|EGF-like 4; calcium-binding (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCAACTGCACGCCGGGCTACG	0.632										TCGA Ovarian(4;0.039)			4	22					1.23904e-05	1.52135e-05	1	0	T	92615997	T	T	92615997	2	4	230	1	0	0	0	0	0	0	0	1	5723	1074	38	3		3	FAT3	11	92615997	Silent	SNP	G	TCGA-CV-7183-01A-11D-2012-08	58130253	92615997	42390519	51	41878											
ALG10	84920	broad.mit.edu	37	chr12	34179455	34179455	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagtttggaaattcacttatGctcataaatacttgctagca	13	15	6	7	0	2	0	2	0	0	0	2	1	2	1	0	1	4	4	0	1	7	8			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr12:34179455G>C	uc001rlm.2	+	3	1346	c.1027G>C	c.(1027-1029)GCT>CCT	p.A343P		NM_032834	NP_116223	Q5BKT4	AG10A_HUMAN	asparagine-linked glycosylation 10 homolog	343	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			skin(1)	1	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				ATTCACTTATGCTCATAAATA	0.303													22	87					0	0	0	0	C	34179455	C	C	34179455	3	2	230	1	0	0	0	0	1	0	0	0	511	1319	46	4	1037	4	ALG10	12	34179455	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08		34179455	99672440	52	41879											
MLL2	8085	broad.mit.edu	37	chr12	49415846	49415846	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctctcctttggggattcGccggctggagatgatgatga	6	12	13	10	2	1	4	0	3	1	1	4	6	2	5	3	4	0	1	3	4	0	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr12:49415846G>A	uc001rta.3	-	53	16501	c.16501C>T	c.(16501-16503)CGA>TGA	p.R5501*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5501	SET.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding	p.R5231*(1)		kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTGGGGATTCGCCGGCTGGAG	0.512			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			45	127					0	0	0	0	A	49415846	A	A	49415846	4	1	230	1	0	0	0	0	0	1	0	0	9674	1095	38	1	120	1	MLL2	12	49415846	Nonsense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	15236391	49415846	84436049	53	41880											
KLHL1	57626	broad.mit.edu	37	chr13	70549904	70549904	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggagtccaaatcactttgAggtgtcattgaatggccggt	9	12	12	8	1	2	2	2	2	0	0	3	3	3	3	2	4	0	0	2	4	2	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr13:70549904A>C	uc001vip.2	-	2	1322	c.528T>G	c.(526-528)CCT>CCG	p.P176P	KLHL1_uc010thm.1_Intron	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	176					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AATCACTTTGAGGTGTCATTG	0.338													14	42					0	0	0	0	C	70549904	C	C	70549904	2	2	230	1	0	0	0	0	0	0	0	1	8404	291	11	5		5	KLHL1	13	70549904	Silent	SNP	A	TCGA-CV-7183-01A-11D-2012-08		70549904	44619974	54	41881											
RNF113B	140432	broad.mit.edu	37	chr13	98828825	98828825	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcccgttcaatctcccacccGagcttgtaatcggaacggtc	8	10	8	15	4	2	0	1	0	1	0	6	2	3	1	3	2	2	3	3	2	3	3			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr13:98828825G>A	uc001vnk.2	-	1	697	c.666C>T	c.(664-666)CTC>CTT	p.L222L	FARP1_uc001vnh.2_Intron|FARP1_uc001vni.2_Intron|FARP1_uc001vnj.2_Intron	NM_178861	NP_849192	Q8IZP6	R113B_HUMAN	ring finger protein 113B	222							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			TCTCCCACCCGAGCTTGTAAT	0.532													32	93					0	0	0	0	A	98828825	A	A	98828825	2	1	230	1	0	0	0	0	0	0	0	1	13493	1045	37	1		1	RNF113B	13	98828825	Silent	SNP	G	TCGA-CV-7183-01A-11D-2012-08	28278921	98828825	16341053	55	41882											
CHD8	57680	broad.mit.edu	37	chr14	21863099	21863099	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctcccgccgtgcaatttCtttcagcttgaaggctgctt	5	16	8	12	2	3	1	1	1	2	0	4	1	3	1	2	1	3	4	2	1	2	5			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr14:21863099C>A	uc001was.1	-	30	4619	c.4525G>T	c.(4525-4527)GAA>TAA	p.E1509*	CHD8_uc001war.1_Nonsense_Mutation_p.E1405*|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1788					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CGTGCAATTTCTTTCAGCTTG	0.493													24	62					5.61819e-17	7.51524e-17	1	0	A	21863099	A	A	21863099	4	1	230	1	0	0	0	0	0	1	0	0	3346	922	32	2	2419	2	CHD8	14	21863099	Nonsense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08		21863099	85486441	56	41883											
PSMC6	5706	broad.mit.edu	37	chr14	53175510	53175510	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagctaccaatggaccaagAtatgttgtgggttgtcgtcg	11	11	12	7	2	0	1	0	0	0	1	2	2	0	2	2	2	2	3	2	2	5	4			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr14:53175510A>T	uc010tqx.1	+	4	276	c.276A>T	c.(274-276)AGA>AGT	p.R92S	PSMC6_uc010tqv.1_Missense_Mutation_p.R92S|PSMC6_uc010tqw.1_Missense_Mutation_p.R58S	NM_002806	NP_002797	P62333	PRS10_HUMAN	proteasome 26S ATPase subunit 6	78					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			lung(1)	1	Breast(41;0.176)					ATGGACCAAGATATGTTGTGG	0.219													15	42					0	0	0	0	T	53175510	T	T	53175510	3	4	230	1	0	0	0	0	1	0	0	0	12753	330	12	5	290	5	PSMC6	14	53175510	Missense_Mutation	SNP	A	TCGA-CV-7183-01A-11D-2012-08	31312411	53175510	54174030	57	41884											
MAPKBP1	23005	broad.mit.edu	37	chr15	42109605	42109605	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagtgatgggcaagtccgCatgatcagctgtggagcaga	10	7	15	9	1	1	3	1	2	0	1	2	4	2	4	2	2	2	4	2	2	1	0			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr15:42109605C>T	uc001zok.3	+	16	2035	c.1749C>T	c.(1747-1749)CGC>CGT	p.R583R	MAPKBP1_uc001zoj.3_Silent_p.R577R|MAPKBP1_uc010bcj.2_Silent_p.R84R|MAPKBP1_uc010bci.2_Silent_p.R577R|MAPKBP1_uc010udb.1_Silent_p.R416R|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Silent_p.R84R	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	583	WD 9.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GGCAAGTCCGCATGATCAGCT	0.612													18	52					0	0	0	0	T	42109605	T	T	42109605	2	4	230	1	0	0	0	0	0	0	0	1	9345	697	25	4		4	MAPKBP1	15	42109605	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08		42109605	60421787	58	41885											
TP53BP1	7158	broad.mit.edu	37	chr15	43771645	43771645	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgtacatccttactgggCtgtgctgtcacagggatgtc	8	12	11	10	0	1	0	1	0	0	0	3	1	2	1	1	2	3	3	1	2	2	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr15:43771645C>T	uc001zrs.2	-	7	871	c.723G>A	c.(721-723)CAG>CAA	p.Q241Q	TP53BP1_uc010udp.1_Silent_p.Q241Q|TP53BP1_uc001zrq.3_Silent_p.Q246Q|TP53BP1_uc001zrr.3_Silent_p.Q246Q|TP53BP1_uc010udq.1_Silent_p.Q246Q	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	241					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CCTTACTGGGCTGTGCTGTCA	0.418								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					29	61					0	0	0	0	T	43771645	T	T	43771645	2	4	230	1	0	0	0	0	0	0	0	1	16450	796	28	4		4	TP53BP1	15	43771645	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08	1662040	43771645	58759747	59	41886											
GTF3C1	2975	broad.mit.edu	37	chr16	27504019	27504019	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgaaggttctccaccacCgaaaaaatgtaacgcctaga	14	8	7	12	2	2	2	0	1	2	1	3	3	2	2	4	1	1	2	4	1	6	3			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr16:27504019C>T	uc002dov.1	-	18	2932	c.2892G>A	c.(2890-2892)TCG>TCA	p.S964S	GTF3C1_uc002dou.2_Silent_p.S964S	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	964						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TCTCCACCACCGAAAAAATGT	0.557													32	74					0	0	0	0	T	27504019	T	T	27504019	2	4	230	1	0	0	0	0	0	0	0	1	6911	639	23	1		1	GTF3C1	16	27504019	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08		27504019	62850734	60	41887											
SRCAP	10847	broad.mit.edu	37	chr16	30749849	30749850	+	Frame_Shift_Ins	INS	-	A	A																															gcccttcattgctcgccgtcINSacattgagctgggggtgact																										TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr16:30749849_30749850insA	uc002dze.1	+	34	8873_8874	c.8488_8489insA	c.(8488-8490)CACfs	p.H2830fs	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Frame_Shift_Ins_p.H2625fs	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2830	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGCTCGCCGTCACATTGAGCTG	0.644													---	---	---								A	30749850	A	A	30749849	7	5	230	1	0	1	1	0	0	0	0	0	15201	826	29	0	8614	0	SRCAP	16	30749849	Frame_Shift_Ins	INS	-	TCGA-CV-7183-01A-11D-2012-08	3245830	30749849	59604904	61	41888											
FHOD1	29109	broad.mit.edu	37	chr16	67264614	67264614	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggccagctcatgcttggcCaagctccgcaggctctcctc	5	8	12	16	1	2	0	1	0	1	0	5	0	3	0	4	4	3	5	4	4	1	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr16:67264614C>T	uc002esl.2	-	18	2860	c.2748G>A	c.(2746-2748)TTG>TTA	p.L916L	FHOD1_uc002esk.2_5'UTR|FHOD1_uc010ced.2_Silent_p.L723L	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	916	Potential.|FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		CATGCTTGGCCAAGCTCCGCA	0.662													41	150					0	0	0	0	T	67264614	T	T	67264614	2	4	230	1	0	0	0	0	0	0	0	1	5914	593	21	4		4	FHOD1	16	67264614	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08	36514765	67264614	23090139	62	41889											
MYH4	4622	broad.mit.edu	37	chr17	10369888	10369888	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcggtcttggctgtcacctTccccccttccctgctctgca	2	14	7	18	1	3	0	1	0	2	0	6	0	5	0	5	2	2	3	5	2	0	4			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr17:10369888T>C	uc002gmn.2	-	3	286	c.175A>G	c.(175-177)AAG>GAG	p.K59E	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	59	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GCTGTCACCTTCCCCCCTTCC	0.463													3	235					0	0	0	0	C	10369888	C	C	10369888	3	2	230	1	0	0	0	0	1	0	0	0	10090	1792	62	5	5796	5	MYH4	17	10369888	Missense_Mutation	SNP	T	TCGA-CV-7183-01A-11D-2012-08		10369888	70825322	63	41890											
KSR1	8844	broad.mit.edu	37	chr17	25936285	25936286	+	Frame_Shift_Del	DEL	TA	-	-																															tcaaatctaagaacgtcttcTatgacaacggcaaggtggtc																										TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr17:25936285_25936286delTA	uc010crg.2	+	17	2255_2256	c.1810_1811delTA	c.(1810-1812)TATfs	p.Y604fs	KSR1_uc002gzm.2_Frame_Shift_Del_p.Y383fs|KSR1_uc002gzn.2_5'Flank	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	739	Protein kinase.				Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GAACGTCTTCTATGACAACGGC	0.525													---	---	---								-	25936286	-	-	25936285	7	5	230	1	0	1	0	1	0	0	0	0	8621	1522	53	0	1864	0	KSR1	17	25936285	Frame_Shift_Del	DEL	TA	TCGA-CV-7183-01A-11D-2012-08	15566397	25936285	55258925	64	41891											
NUFIP2	57532	broad.mit.edu	37	chr17	27613086	27613087	+	Frame_Shift_Del	DEL	TC	-	-																															ctttctaggcctctctggtaTctctgttctttggcagagcc																										TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr17:27613086_27613087delTC	uc002hdy.3	-	2	2014_2015	c.1925_1926delGA	c.(1924-1926)AGAfs	p.R642fs	NUFIP2_uc002hdx.3_Intron	NM_020772	NP_065823	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein	642						nucleus|polysomal ribosome	protein binding|RNA binding			skin(2)|ovary(1)|breast(1)	4			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			CTCTCTGGTATCTCTGTTCTTT	0.426													---	---	---								-	27613087	-	-	27613086	7	5	230	1	0	1	0	1	0	0	0	0	10803	1432	50	0	173	0	NUFIP2	17	27613086	Frame_Shift_Del	DEL	TC	TCGA-CV-7183-01A-11D-2012-08	1676801	27613086	53582124	65	41892											
ADAM11	4185	broad.mit.edu	37	chr17	42855361	42855361	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcatctgtcagccagactgGacaggcaaagactgcagtat	12	8	11	10	0	2	2	1	0	1	2	2	3	2	3	1	2	3	4	1	2	2	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr17:42855361G>A	uc002ihh.2	+	24	2112	c.2112G>A	c.(2110-2112)TGG>TGA	p.W704*	ADAM11_uc010wjd.1_Nonsense_Mutation_p.W504*|ADAM11_uc002ihi.2_Missense_Mutation_p.G57E	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	704	EGF-like.|Extracellular (Potential).				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				AGCCAGACTGGACAGGCAAAG	0.612													37	127					0	0	0	0	A	42855361	A	A	42855361	4	1	230	1	0	0	0	0	0	1	0	0	235	1183	41	2	2206	2	ADAM11	17	42855361	Nonsense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	15242275	42855361	38339849	66	41893											
CA4	762	broad.mit.edu	37	chr17	58234830	58234830	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggccagcatttctggaggagGactgcctgccccataccagg	8	7	13	13	0	1	0	0	0	1	0	1	3	1	3	5	5	4	1	5	5	1	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr17:58234830G>A	uc002iym.3	+	4	405	c.311G>A	c.(310-312)GGA>GAA	p.G104E	CA4_uc010wou.1_Intron	NM_000717	NP_000708	P22748	CAH4_HUMAN	carbonic anhydrase IV precursor	104					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TCTGGAGGAGGACTGCCTGCC	0.587													23	92					0	0	0	0	A	58234830	A	A	58234830	3	1	230	1	0	0	0	0	1	0	0	0	2530	1174	41	2	325	2	CA4	17	58234830	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	15379469	58234830	22960380	67	41894											
TNRC6C	57690	broad.mit.edu	37	chr17	76082938	76082938	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtctctgcctgccaggttgCgcgcacaatcactaatctgc	7	11	9	14	2	3	0	1	0	2	0	4	0	3	0	2	1	4	2	2	1	2	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr17:76082938C>T	uc002jud.2	+	14	4166	c.3566C>T	c.(3565-3567)GCG>GTG	p.A1189V	TNRC6C_uc002juf.2_Missense_Mutation_p.A1186V	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1189	Potential.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TGCCAGGTTGCGCGCACAATC	0.592													5	166					0	0	0	0	T	76082938	T	T	76082938	3	4	230	1	0	0	0	0	1	0	0	0	16408	768	27	1	3608	1	TNRC6C	17	76082938	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	17848108	76082938	5112272	68	41895											
FBN3	84467	broad.mit.edu	37	chr19	8174522	8174522	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatggactcacccacgcaGcccactccgctggggttcag	8	6	11	16	2	2	0	2	0	0	0	3	1	3	1	3	3	2	4	3	3	0	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr19:8174522G>T	uc002mjf.2	-	34	4470	c.4449C>A	c.(4447-4449)GGC>GGA	p.G1483G		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1483	EGF-like 23; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CACCCACGCAGCCCACTCCGC	0.582													24	79					5.35356e-11	6.89271e-11	1	0	T	8174522	T	T	8174522	2	4	230	1	0	0	0	0	0	0	0	1	5736	958	34	4		4	FBN3	19	8174522	Silent	SNP	G	TCGA-CV-7183-01A-11D-2012-08		8174522	50954461	69	41896											
MAST1	22983	broad.mit.edu	37	chr19	12958457	12958457	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccccctcctcctacgacaacGagatcgtgatgatgaatcac	11	8	7	15	3	1	4	1	3	0	1	4	6	3	4	4	0	2	0	4	0	3	1			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr19:12958457G>C	uc002mvm.2	+	6	648	c.520G>C	c.(520-522)GAG>CAG	p.E174Q	MAST1_uc002mvk.2_Missense_Mutation_p.E170Q|MAST1_uc002mvl.2_Silent_p.T147T	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	174					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CTACGACAACGAGATCGTGAT	0.652											OREG0025277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	54					0	0	0	0	C	12958457	C	C	12958457	3	2	230	1	0	0	0	0	1	0	0	0	9377	1059	37	3	542	3	MAST1	19	12958457	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	4783935	12958457	46170526	70	41897											
SYMPK	8189	broad.mit.edu	37	chr19	46318949	46318949	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caaggtcagcccgcccgctgCcgtctcctggtgaccgggga	5	6	14	16	4	2	1	1	1	1	0	3	2	2	2	5	4	2	1	5	4	1	0			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr19:46318949C>T	uc002pdn.2	-	27	3939	c.3694G>A	c.(3694-3696)GCA>ACA	p.A1232T	RSPH6A_uc002pdm.2_5'Flank	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	1232					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CCGCCCGCTGCCGTCTCCTGG	0.701													4	13					0	0	0	0	T	46318949	T	T	46318949	3	4	230	1	0	0	0	0	1	0	0	0	15505	739	26	4	134	4	SYMPK	19	46318949	Missense_Mutation	SNP	C	TCGA-CV-7183-01A-11D-2012-08	33360492	46318949	12810034	71	41898											
IRF2BP1	26145	broad.mit.edu	37	chr19	46388435	46388436	+	Frame_Shift_Del	DEL	TC	-	-																															gtccgcattcctctgctgctTctctttctcgaaatcggagc																										TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr19:46388435_46388436delTC	uc002pds.1	-	1	941_942	c.597_598delGA	c.(595-600)GAGAAGfs	p.E199fs		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	199_200	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CTCTGCTGCTTCTCTTTCTCGA	0.644													---	---	---								-	46388436	-	-	46388435	7	5	230	1	0	1	0	1	0	0	0	0	7868	1792	62	0	1160	0	IRF2BP1	19	46388435	Frame_Shift_Del	DEL	TC	TCGA-CV-7183-01A-11D-2012-08	69486	46388435	12740548	72	41899											
KLK4	9622	broad.mit.edu	37	chr19	51413946	51413946	+	Frame_Shift_Del	DEL	G	-	-																															tcagatacctgcgacaccaaGgatgaggtaccccaggaacc																										TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr19:51413946delG	uc002pua.1	-	1	49	c.49delC	c.(49-51)CTTfs	p.L17fs	KLK4_uc002pty.1_5'Flank|KLK4_uc002ptz.1_5'Flank|KLK4_uc002pub.1_5'UTR|KLK4_uc002puc.1_RNA|KLK4_uc010eoi.1_5'Flank|KLK4_uc002pud.1_5'Flank	NM_004917	NP_004908	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4 preproprotein	17					proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		GCGACACCAAGGATGAGGTAC	0.552													---	---	---								-	51413946	-	-	51413946	7	5	230	1	0	1	0	1	0	0	0	0	8445	1000	35	0	735	0	KLK4	19	51413946	Frame_Shift_Del	DEL	G	TCGA-CV-7183-01A-11D-2012-08	5025511	51413946	7715037	73	41900											
LILRA1	11024	broad.mit.edu	37	chr19	55107315	55107315	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccctgtgagccgctcctaCgggggccagtacagatgctc	6	7	14	14	2	0	2	0	1	0	1	2	2	1	2	4	3	4	3	4	3	2	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr19:55107315C>T	uc002qgh.1	+	6	1055	c.873C>T	c.(871-873)TAC>TAT	p.Y291Y	LILRA2_uc010yfg.1_Silent_p.Y289Y|LILRA1_uc010yfh.1_Silent_p.Y291Y	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	291	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GCCGCTCCTACGGGGGCCAGT	0.662													28	70					0	0	0	0	T	55107315	T	T	55107315	2	4	230	1	0	0	0	0	0	0	0	1	8825	547	19	1		1	LILRA1	19	55107315	Silent	SNP	C	TCGA-CV-7183-01A-11D-2012-08	3693369	55107315	4021668	74	41901											
VPS16	64601	broad.mit.edu	37	chr20	2844656	2844656	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattaaccagaagctgggggAcacgcctggtgtctcttact	9	10	11	11	1	1	1	0	0	1	1	2	2	1	2	2	3	3	1	2	3	3	2			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr20:2844656A>G	uc002whe.2	+	16	1586	c.1538A>G	c.(1537-1539)GAC>GGC	p.D513G	VPS16_uc002whh.2_RNA|PTPRA_uc002whj.2_5'Flank|VPS16_uc002whf.2_Missense_Mutation_p.D369G|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Missense_Mutation_p.D199G|VPS16_uc002whi.2_5'UTR	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	513					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						AAGCTGGGGGACACGCCTGGT	0.582													5	64					0	0	0	0	G	2844656	G	G	2844656	3	3	230	1	0	0	0	0	1	0	0	0	17261	275	10	5	1600	5	VPS16	20	2844656	Missense_Mutation	SNP	A	TCGA-CV-7183-01A-11D-2012-08		2844656	60180864	75	41902											
NINL	22981	broad.mit.edu	37	chr20	25460831	25460831	+	Frame_Shift_Del	DEL	T	-	-																															gggtcctgaggtcttggtaaTgctcctttacctgctccatc																										TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr20:25460831delT	uc002wux.1	-	15	1957	c.1883delA	c.(1882-1884)CATfs	p.H628fs	NINL_uc010gdn.1_Frame_Shift_Del_p.H628fs|NINL_uc010gdo.1_Frame_Shift_Del_p.H411fs	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	628	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GTCTTGGTAATGCTCCTTTAC	0.532													---	---	---								-	25460831	-	-	25460831	7	5	230	1	0	1	0	1	0	0	0	0	10474	1464	51	0	2305	0	NINL	20	25460831	Frame_Shift_Del	DEL	T	TCGA-CV-7183-01A-11D-2012-08	22616175	25460831	37564689	76	41903											
PHACTR3	116154	broad.mit.edu	37	chr20	58318189	58318189	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccaaacgcccccggcgcGtcctgaatatctggtctcag	8	7	11	15	4	2	1	1	1	2	0	4	2	3	2	4	3	1	0	4	3	3	1	rs143288140		TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr20:58318189G>A	uc002yau.2	+	2	613	c.146G>A	c.(145-147)CGT>CAT	p.R49H	PHACTR3_uc002yat.2_Missense_Mutation_p.R46H|PHACTR3_uc010zzw.1_Missense_Mutation_p.R8H|PHACTR3_uc002yav.2_Missense_Mutation_p.R8H|PHACTR3_uc002yaw.2_Missense_Mutation_p.R8H|PHACTR3_uc002yax.2_Missense_Mutation_p.R8H	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	49						nuclear matrix	actin binding|protein phosphatase inhibitor activity	p.R49H(1)		ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CCCCCGGCGCGTCCTGAATAT	0.567													24	86					0	0	0	0	A	58318189	A	A	58318189	3	1	230	1	0	0	0	0	1	0	0	0	11866	1145	40	1	152	1	PHACTR3	20	58318189	Missense_Mutation	SNP	G	TCGA-CV-7183-01A-11D-2012-08	32857358	58318189	4707331	77	41904											
SFRS15	57466	broad.mit.edu	37	chr21	33065610	33065610	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tataaaggttgagttaccacTtgcagtttccggtttcactt	9	16	8	8	1	1	1	1	1	0	0	2	1	2	1	2	2	2	5	2	2	4	8			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chr21:33065610T>A	uc002ypd.2	-	12	1936	c.1510A>T	c.(1510-1512)AGT>TGT	p.S504C	SFRS15_uc002ype.2_Missense_Mutation_p.S504C|SFRS15_uc010glu.2_Missense_Mutation_p.S489C|SFRS15_uc002ypf.1_Missense_Mutation_p.S178C	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	504						nucleus	nucleotide binding|RNA binding				0						GAGTTACCACTTGCAGTTTCC	0.388													20	58					0	0	0	0	A	33065610	A	A	33065610	3	1	230	1	0	0	0	0	1	0	0	0	14236	1609	56	5	1969	5	SFRS15	21	33065610	Missense_Mutation	SNP	T	TCGA-CV-7183-01A-11D-2012-08		33065610	15064285	78	41905											
MAGEA12	4111	broad.mit.edu	37	chrX	151896244	151896244	+	RNA	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctggatagtgttggcccActccattcctcaggtttttt	5	16	10	10	0	1	0	1	0	0	0	3	1	3	1	3	4	0	3	3	4	1	6			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chrX:151896244A>C	uc004fgb.2	-	4		c.523T>G						P43365	MAGAC_HUMAN	Homo sapiens melanoma antigen family A, 12, mRNA (cDNA clone MGC:4914 IMAGE:3450217), complete cds.											skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GTGTTGGCCCACTCCATTCCT	0.522													11	41					0	0	0	0	C	151896244	C	C	151896244	1	2	230	0	1	0	0	0	0	0	0	0	9217	174	6	5		5	MAGEA12	23	151896244	RNA	SNP	A	TCGA-CV-7183-01A-11D-2012-08		151896244	3374316	79	41906											
IRAK1	3654	broad.mit.edu	37	chrX	153278841	153278841	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcctccgaatgcccgggcAcccccgccaccactgcctgc	5	4	10	22	4	0	0	0	0	0	0	1	1	1	0	8	2	3	1	8	2	1	0			TCGA-CV-7183-01A-11D-2012-08	TCGA-CV-7183-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	172e7b30-829e-40b2-976e-4971cd1724a9	207e1907-6829-4ac9-8e37-606e14db40a3	g.chrX:153278841A>C	uc004fjs.1	-	12	1662	c.1583T>G	c.(1582-1584)GTG>GGG	p.V528G	IRAK1_uc004fjr.1_Intron|IRAK1_uc004fjt.1_Missense_Mutation_p.V449G|IRAK1_uc010nur.2_Intron	NM_001569	NP_001560	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	528					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ATGCCCGGGCACCCCCGCCAC	0.662													6	21					0	0	0	0	C	153278841	C	C	153278841	3	2	230	1	0	0	0	0	1	0	0	0	7860	159	6	5	567	5	IRAK1	23	153278841	Missense_Mutation	SNP	A	TCGA-CV-7183-01A-11D-2012-08	1382597	153278841	1991719	80	41907											
RER1	11079	broad.mit.edu	37	chr1	2327276	2327276	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atccgtccatgggaaaccttCggtggtgtacagatttttca	9	13	10	9	2	1	1	1	0	0	1	4	2	3	2	3	3	2	1	3	3	2	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:2327276C>T	uc001aje.1	+	2	238	c.47C>T	c.(46-48)TCG>TTG	p.S16L	RER1_uc001ajf.1_Missense_Mutation_p.S16L	NM_007033	NP_008964	O15258	RER1_HUMAN	RER1 retention in endoplasmic reticulum 1	16					retrograde vesicle-mediated transport, Golgi to ER	integral to Golgi membrane					0	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.28e-37)|OV - Ovarian serous cystadenocarcinoma(86;8.29e-23)|GBM - Glioblastoma multiforme(42;4.71e-08)|Colorectal(212;4.73e-05)|COAD - Colon adenocarcinoma(227;0.00021)|Kidney(185;0.00116)|BRCA - Breast invasive adenocarcinoma(365;0.00459)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0182)|Lung(427;0.204)		GGGAAACCTTCGGTGGTGTAC	0.413													14	60					0	0	0	0	T	2327276	T	T	2327276	3	4	231	1	0	0	0	0	1	0	0	0	13295	893	31	1	49	1	RER1	1	2327276	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08		2327276	246923345	1	41908											
PRAMEF16	654348	broad.mit.edu	37	chr1	13495995	13495995	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacttcaagtgctggatttgCgggatgttgatgggaatttc	9	14	13	5	1	1	1	1	1	0	0	2	4	1	4	0	3	3	2	0	3	3	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:13495995C>A	uc001aux.2	+	2	346	c.316C>A	c.(316-318)CGG>AGG	p.R106R		NM_001045480	NP_001038945	Q5VWM1	PRA16_HUMAN	PRAME family member 16	106											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGGATTTGCGGGATGTTGA	0.522													59	54					3.33908e-46	5.24712e-46	1	0	A	13495995	A	A	13495995	2	1	231	1	0	0	0	0	0	0	0	1	12491	759	27	3		3	PRAMEF16	1	13495995	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	11168719	13495995	235754626	2	41909											
PADI1	29943	broad.mit.edu	37	chr1	17552556	17552556	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacatgtccccaatgctgctGagctgcaatggccccgacaa	10	7	10	14	1	0	1	0	1	0	0	1	3	1	1	4	1	4	4	4	1	3	0			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:17552556G>C	uc001bah.1	+	6	647	c.555G>C	c.(553-555)CTG>CTC	p.L185L		NM_013358	NP_037490	Q9ULC6	PADI1_HUMAN	peptidylarginine deiminase type I	185					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity				0		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	CAATGCTGCTGAGCTGCAATG	0.567													10	62					0	0	0	0	C	17552556	C	C	17552556	2	2	231	1	0	0	0	0	0	0	0	1	11431	1277	45	2		2	PADI1	1	17552556	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	4056561	17552556	231698065	3	41910											
ARID1A	8289	broad.mit.edu	37	chr1	27106940	27106940	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggacagcctggcagctcgtgCcattgcagtgcagaagggca	9	6	15	11	1	0	1	0	0	0	1	1	2	0	2	2	3	5	5	2	3	1	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:27106940C>T	uc001bmv.1	+	20	6924	c.6551C>T	c.(6550-6552)GCC>GTC	p.A2184V	ARID1A_uc001bmu.1_Missense_Mutation_p.A1967V|ARID1A_uc001bmx.1_Missense_Mutation_p.A1030V|ARID1A_uc009vsm.1_Missense_Mutation_p.A512V|ARID1A_uc009vsn.1_Missense_Mutation_p.A426V	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2184					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCAGCTCGTGCCATTGCAGTG	0.632			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								4	81					0	0	0	0	T	27106940	T	T	27106940	3	4	231	1	0	0	0	0	1	0	0	0	913	739	26	4	6629	4	ARID1A	1	27106940	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	9554384	27106940	222143681	4	41911											
PSMB2	5690	broad.mit.edu	37	chr1	36068938	36068938	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgtcaatgattcgaacaCtgaaggttggcagattcagg	11	13	11	6	1	2	3	2	2	0	1	3	4	2	3	0	3	1	2	0	3	3	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:36068938C>G	uc001bzf.1	-	6	646	c.536G>C	c.(535-537)AGT>ACT	p.S179T	PSMB2_uc001bzd.1_Intron|PSMB2_uc010ohz.1_Missense_Mutation_p.S154T|PSMB2_uc001bzg.1_Missense_Mutation_p.S179T	NM_002794	NP_002785	P49721	PSB2_HUMAN	proteasome beta 2 subunit	179					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)			Bortezomib(DB00188)	GATTCGAACACTGAAGGTTGG	0.388													15	74					0	0	0	0	G	36068938	G	G	36068938	3	3	231	1	0	0	0	0	1	0	0	0	12739	565	20	4	73	4	PSMB2	1	36068938	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	8961998	36068938	213181683	5	41912											
KDM4A	9682	broad.mit.edu	37	chr1	44156525	44156525	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttccccttaggttgaatttGgaggctttaatcagaactgt	9	16	9	7	0	1	2	1	1	0	1	2	3	2	3	2	3	1	2	2	3	4	6			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:44156525G>T	uc001cjx.2	+	14	2213	c.2047G>T	c.(2047-2049)GGA>TGA	p.G683*	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	683					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						GGTTGAATTTGGAGGCTTTAA	0.478													7	663					0.00621372	0.00821705	1	0	T	44156525	T	T	44156525	4	4	231	1	0	0	0	0	0	1	0	0	8167	1349	47	4	2097	4	KDM4A	1	44156525	Nonsense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	8087587	44156525	205094096	6	41913											
CDKN2C	1031	broad.mit.edu	37	chr1	51439744	51439744	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aacatcgaggataatgaaggGaacctgcccttgcacttggc	12	8	11	10	1	0	1	0	1	0	0	1	4	0	3	2	3	4	1	2	3	4	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:51439744G>C	uc001csf.2	+	3	1525	c.309G>C	c.(307-309)GGG>GGC	p.G103G	CDKN2C_uc001csg.2_Silent_p.G103G	NM_001262	NP_001253	P42773	CDN2C_HUMAN	cyclin-dependent kinase inhibitor 2C	103	ANK 4.				cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0?(4)|p.?(1)		central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(5)|ovary(2)|thyroid(1)|lung(1)|kidney(1)	17				GBM - Glioblastoma multiforme(3;3.61e-13)|all cancers(3;0.00151)		ATAATGAAGGGAACCTGCCCT	0.532			D		glioma|MM				Multiple_Endocrine_Neoplasia_type_1				6	59					0	0	0	0	C	51439744	C	C	51439744	2	2	231	1	0	0	0	0	0	0	0	1	3180	1161	41	2		2	CDKN2C	1	51439744	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	7283219	51439744	197810877	7	41914											
NBPF9	400818	broad.mit.edu	37	chr1	144619350	144619350	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acattttgtatttatagaaaAtgacgaagatgaggatgaag	17	12	10	2	1	0	5	0	3	0	2	0	7	0	6	0	1	0	1	0	1	7	6			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:144619350A>G	uc009wig.1	+	7	573	c.497A>G	c.(496-498)AAT>AGT	p.N166S	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.N166S|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.N97S|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Missense_Mutation_p.N97S|NBPF9_uc010oyg.1_Missense_Mutation_p.N131S|NBPF9_uc009wii.1_Intron	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	166	NBPF 1.					cytoplasm					0						TTTATAGAAAATGACGAAGAT	0.423													137	253					0	0	0	0	G	144619350	G	G	144619350	3	3	231	1	0	0	0	0	1	0	0	0	10253	101	4	5	509	5	NBPF9	1	144619350	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	93179606	144619350	104631271	8	41915											
SV2A	9900	broad.mit.edu	37	chr1	149884914	149884914	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccactggaagcggccgtggCcacactcccgtaggatggct	7	7	13	14	3	0	0	0	0	0	0	2	2	2	2	4	5	1	2	4	5	2	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:149884914C>T	uc001etg.2	-	2	970	c.479G>A	c.(478-480)GGC>GAC	p.G160D	SV2A_uc001eth.2_Missense_Mutation_p.G160D	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	160	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	GCGGCCGTGGCCACACTCCCG	0.617													57	63					0	0	0	0	T	149884914	T	T	149884914	3	4	231	1	0	0	0	0	1	0	0	0	15483	739	26	4	1797	4	SV2A	1	149884914	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	5265564	149884914	99365707	9	41916											
TCHH	7062	broad.mit.edu	37	chr1	152085381	152085381	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtaacaggctctcctttccGtcacaccgggctcgcttctc	5	12	8	16	3	3	0	1	0	2	0	7	0	4	0	3	2	1	4	3	2	1	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:152085381G>A	uc001ezp.2	-	2	312	c.312C>T	c.(310-312)GAC>GAT	p.D104D	TCHH_uc009wne.1_Silent_p.D104D	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	104					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTCCTTTCCGTCACACCGGG	0.527													135	97					0	0	0	0	A	152085381	A	A	152085381	2	1	231	1	0	0	0	0	0	0	0	1	15766	1136	40	1		1	TCHH	1	152085381	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	2200467	152085381	97165240	10	41917											
LCE2A	353139	broad.mit.edu	37	chr1	152671632	152671632	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcaccggcaccagagcccCgattgttgtgagtgtgaacc	8	7	13	13	3	0	3	0	2	0	1	0	4	0	3	5	2	2	3	5	2	1	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:152671632C>T	uc001faj.2	+	2	306	c.255C>T	c.(253-255)CCC>CCT	p.P85P		NM_178428	NP_848515	Q5TA79	LCE2A_HUMAN	late cornified envelope 2A	85	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCAGAGCCCCGATTGTTGTG	0.657													120	82					0	0	0	0	T	152671632	T	T	152671632	2	4	231	1	0	0	0	0	0	0	0	1	8705	639	23	1		1	LCE2A	1	152671632	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	586251	152671632	96578989	11	41918											
GON4L	54856	broad.mit.edu	37	chr1	155744943	155744943	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaagggcgatggagctttGagcaaaggttcccagctctt	9	10	14	8	1	1	2	0	2	1	0	2	4	2	3	1	3	3	4	1	3	2	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:155744943G>A	uc001flz.2	-	17	2297	c.2200C>T	c.(2200-2202)CAA>TAA	p.Q734*	GON4L_uc001fly.1_Nonsense_Mutation_p.Q734*|GON4L_uc009wrh.1_Nonsense_Mutation_p.Q734*|GON4L_uc001fma.1_Nonsense_Mutation_p.Q734*|GON4L_uc001fmb.3_5'UTR|GON4L_uc001fmc.2_Nonsense_Mutation_p.Q734*|GON4L_uc001fmd.3_Nonsense_Mutation_p.Q734*|GON4L_uc009wri.2_Nonsense_Mutation_p.Q320*|GON4L_uc009wrj.1_Nonsense_Mutation_p.Q220*|GON4L_uc001fme.2_Nonsense_Mutation_p.Q562*	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	734					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					ATGGAGCTTTGAGCAAAGGTT	0.438													17	129					0	0	0	0	A	155744943	A	A	155744943	4	1	231	1	0	0	0	0	0	1	0	0	6609	1299	45	2	4703	2	GON4L	1	155744943	Nonsense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	3073311	155744943	93505678	12	41919											
FCRLA	84824	broad.mit.edu	37	chr1	161677051	161677051	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggagacctaaacacagtCaccatgaagctgggctgtgt	12	7	12	10	0	1	2	1	1	0	1	1	3	1	2	2	2	2	3	2	2	3	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:161677051C>T	uc001gbe.2	+	1	290	c.48C>T	c.(46-48)GTC>GTT	p.V16V	FCRLA_uc001gbd.2_Silent_p.V16V|FCRLA_uc001gbf.2_Silent_p.V16V|FCRLA_uc001gbg.2_Silent_p.V16V|FCRLA_uc009wuo.2_Silent_p.V16V|FCRLA_uc009wup.2_Silent_p.V16V|FCRLA_uc009wuq.2_Silent_p.V16V	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	Error:Variant_position_missing_in_Q7L513_after_alignment					cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			TAAACACAGTCACCATGAAGC	0.463													6	33					0	0	0	0	T	161677051	T	T	161677051	2	4	231	1	0	0	0	0	0	0	0	1	5832	813	29	2		2	FCRLA	1	161677051	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	5932108	161677051	87573570	13	41920											
DUSP27	92235	broad.mit.edu	37	chr1	167088559	167088559	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaatgctgcgcatggcaccGgcgtttacactggccccgaa	8	8	12	13	4	0	1	0	1	0	0	0	2	0	1	3	3	3	4	3	3	3	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:167088559G>A	uc001geb.1	+	4	511	c.511G>A	c.(511-513)GGC>AGC	p.G171S		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	171					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GCATGGCACCGGCGTTTACAC	0.567													4	37					0	0	0	0	A	167088559	A	A	167088559	3	1	231	1	0	0	0	0	1	0	0	0	4846	1116	39	1	525	1	DUSP27	1	167088559	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	5411508	167088559	82162062	14	41921											
F5	2153	broad.mit.edu	37	chr1	169510609	169510609	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatggctgaggtctggagaaAgggttgtatggctgaggtct	8	12	17	4	0	2	3	0	2	2	1	2	4	2	3	0	6	0	4	0	6	3	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:169510609A>G	uc001ggg.1	-	13	3864	c.3719T>C	c.(3718-3720)CTT>CCT	p.L1240P		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1240	2-7.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTCTGGAGAAAGGGTTGTATG	0.527													4	346					0	0	0	0	G	169510609	G	G	169510609	3	3	231	1	0	0	0	0	1	0	0	0	5373	72	3	5	3007	5	F5	1	169510609	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	2422050	169510609	79740012	15	41922											
TNN	63923	broad.mit.edu	37	chr1	175097245	175097245	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacctaccctgtctccctTgttgcctttaagggtggtcg	4	13	10	14	1	1	0	0	0	1	0	3	0	1	0	5	2	2	1	5	2	2	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:175097245T>G	uc001gkl.1	+	14	3236	c.3123T>G	c.(3121-3123)CTT>CTG	p.L1041L		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1041	Fibronectin type-III 9.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CTGTCTCCCTTGTTGCCTTTA	0.537													8	57					0	0	0	0	G	175097245	G	G	175097245	2	3	231	1	0	0	0	0	0	0	0	1	16389	1799	63	5		5	TNN	1	175097245	Silent	SNP	T	TCGA-CV-7235-01A-11D-2012-08	5586636	175097245	74153376	16	41923											
UCHL5	51377	broad.mit.edu	37	chr1	192985497	192985497	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcttcatttggtttcctgaGctttctttgcgttctgtttt	3	23	7	8	1	4	1	1	1	3	0	5	1	5	1	1	1	2	4	1	1	0	8			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:192985497G>C	uc001gsm.2	-	11	1105	c.974C>G	c.(973-975)GCT>GGT	p.A325G	UCHL5_uc001gsn.2_RNA|UCHL5_uc001gso.2_Missense_Mutation_p.A324G|UCHL5_uc010pov.1_RNA	NM_015984	NP_057068	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	325	Interaction with ADRM1.				DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3						GGTTTCCTGAGCTTTCTTTGC	0.289													12	121					0	0	0	0	C	192985497	C	C	192985497	3	2	231	1	0	0	0	0	1	0	0	0	16990	971	34	4	19	4	UCHL5	1	192985497	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	17888252	192985497	56265124	17	41924											
KCNT2	343450	broad.mit.edu	37	chr1	196295872	196295872	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atccaatagcagtactatggGattaagttctttctttggtc	10	16	8	7	0	2	0	0	0	2	0	4	1	3	1	1	2	2	3	1	2	5	7			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:196295872G>C	uc001gtd.1	-	19	2311	c.2251C>G	c.(2251-2253)CCC>GCC	p.P751A	KCNT2_uc009wyt.1_Intron|KCNT2_uc001gte.1_Missense_Mutation_p.P701A|KCNT2_uc001gtf.1_Missense_Mutation_p.P751A|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.P751A|KCNT2_uc001gth.1_Missense_Mutation_p.P272A	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	751	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity	p.P751P(1)		ovary(5)|breast(1)|skin(1)	7						AGTACTATGGGATTAAGTTCT	0.284													3	38					0	0	0	0	C	196295872	C	C	196295872	3	2	231	1	0	0	0	0	1	0	0	0	8131	1174	41	2	1196	2	KCNT2	1	196295872	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	3310375	196295872	52954749	18	41925											
KDM5B	10765	broad.mit.edu	37	chr1	202733221	202733221	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacccattcgacgtctcagaTtatgagttctggcttccgtt	8	14	8	11	3	2	2	1	1	2	1	5	3	3	2	2	1	1	3	2	1	2	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:202733221T>C	uc001gyf.2	-	6	880	c.764A>G	c.(763-765)AAT>AGT	p.N255S	KDM5B_uc009xag.2_Missense_Mutation_p.N291S|KDM5B_uc001gyg.1_Missense_Mutation_p.N97S	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	255					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						ACGTCTCAGATTATGAGTTCT	0.303													11	42					0	0	0	0	C	202733221	C	C	202733221	3	2	231	1	0	0	0	0	1	0	0	0	8173	1493	52	5	3958	5	KDM5B	1	202733221	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08	6437349	202733221	46517400	19	41926											
RYR2	6262	broad.mit.edu	37	chr1	237969513	237969513	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttttttttgccgctcaccTtctcgacattgctatgggat	5	18	7	11	2	2	0	1	0	1	0	3	2	2	1	2	1	2	2	2	1	1	7			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:237969513T>C	uc001hyl.1	+	99	14348	c.14228T>C	c.(14227-14229)CTT>CCT	p.L4743P	RYR2_uc010pyb.1_Missense_Mutation_p.L176P	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4743					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCCGCTCACCTTCTCGACATT	0.408													24	35					0	0	0	0	C	237969513	C	C	237969513	3	2	231	1	0	0	0	0	1	0	0	0	13834	1609	56	5	14622	5	RYR2	1	237969513	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08	35236292	237969513	11281108	20	41927											
OR2T2	401992	broad.mit.edu	37	chr1	248616736	248616736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgctgcttatccctctatCtgtcatctctgtctcctaca	6	16	5	14	0	5	0	1	0	4	0	8	1	6	0	2	0	3	2	2	0	3	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr1:248616736C>T	uc001iek.1	+	1	638	c.638C>T	c.(637-639)TCT>TTT	p.S213F		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATCCCTCTATCTGTCATCTCT	0.537													9	143					0	0	0	0	T	248616736	T	T	248616736	3	4	231	1	0	0	0	0	1	0	0	0	11074	913	32	2	640	2	OR2T2	1	248616736	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	10647223	248616736	633885	21	41928											
APOB	338	broad.mit.edu	37	chr2	21224635	21224635	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtaagttctcctggagcaagCttcatgtaggggttcatgac	9	12	12	8	0	3	1	2	1	1	0	4	2	3	2	1	3	2	6	1	3	3	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:21224635C>G	uc002red.2	-	29	13787	c.13659G>C	c.(13657-13659)AAG>AAC	p.K4553N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4553					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTGGAGCAAGCTTCATGTAGG	0.348													14	76					0	0	0	0	G	21224635	G	G	21224635	3	3	231	1	0	0	0	0	1	0	0	0	785	796	28	4	36	4	APOB	2	21224635	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08		21224635	221974738	22	41929											
AFF3	3899	broad.mit.edu	37	chr2	100209981	100209984	+	Frame_Shift_Del	DEL	GTTG	-	-																															gccctaggaccactgcccccGttggcagcggcctccttcag																										TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:100209981_100209984delGTTG	uc002tag.2	-	14	2375_2378	c.2139_2142delCAAC	c.(2137-2142)GCCAACfs	p.A713fs	AFF3_uc002taf.2_Frame_Shift_Del_p.A738fs|AFF3_uc010fiq.1_Frame_Shift_Del_p.A713fs|AFF3_uc010yvr.1_Frame_Shift_Del_p.A866fs|AFF3_uc002tah.1_Frame_Shift_Del_p.A738fs	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	713_714					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CACTGCCCCCGTTGGCAGCGGCCT	0.627													---	---	---								-	100209984	-	-	100209981	7	5	231	1	0	1	0	1	0	0	0	0	358	1136	40	0	1582	0	AFF3	2	100209981	Frame_Shift_Del	DEL	GTTG	TCGA-CV-7235-01A-11D-2012-08	78985346	100209981	142989392	23	41930											
NMS	129521	broad.mit.edu	37	chr2	101097599	101097599	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgttgcaggatcacactgcGacctggggacgacccttttt	8	11	11	11	2	1	0	1	0	0	0	1	4	1	2	2	3	2	2	2	3	0	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:101097599G>A	uc002tan.1	+	8	391	c.384G>A	c.(382-384)GCG>GCA	p.A128A		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	128					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						ATCACACTGCGACCTGGGGAC	0.393													18	94					0	0	0	0	A	101097599	A	A	101097599	2	1	231	1	0	0	0	0	0	0	0	1	10556	1045	37	1		1	NMS	2	101097599	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	887618	101097599	142101774	24	41931											
GCC2	9648	broad.mit.edu	37	chr2	109086566	109086566	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agttgatgtgccagattgaaGcatcagctaaggaacatgaa	15	9	11	6	0	1	4	1	3	0	1	1	5	1	5	1	1	4	3	1	1	4	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:109086566G>C	uc002tec.2	+	6	935	c.781G>C	c.(781-783)GCA>CCA	p.A261P	GCC2_uc002ted.2_Missense_Mutation_p.A160P	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	261	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						CCAGATTGAAGCATCAGCTAA	0.358													26	91					0	0	0	0	C	109086566	C	C	109086566	3	2	231	1	0	0	0	0	1	0	0	0	6321	971	34	4	803	4	GCC2	2	109086566	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	7988967	109086566	134112807	25	41932											
GTDC1	79712	broad.mit.edu	37	chr2	144764954	144764954	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtatcaaggccacagtgtgTatcacactctgaattaaaat	15	11	7	8	0	3	1	2	1	1	0	3	1	3	1	1	1	0	2	1	1	6	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:144764954T>A	uc002tvp.2	-	7	949	c.670A>T	c.(670-672)ACA>TCA	p.T224S	GTDC1_uc002tvo.2_Missense_Mutation_p.T224S|GTDC1_uc002tvq.2_Intron|GTDC1_uc002tvr.2_Missense_Mutation_p.T224S|GTDC1_uc010fnn.2_Missense_Mutation_p.T224S|GTDC1_uc002tvs.2_Missense_Mutation_p.T192S|GTDC1_uc010fno.2_Missense_Mutation_p.T95S|GTDC1_uc002tvt.1_Missense_Mutation_p.T224S	NM_001006636	NP_001006637	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	224					biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)		CCACAGTGTGTATCACACTCT	0.418													34	33					0	0	0	0	A	144764954	A	A	144764954	3	1	231	1	0	0	0	0	1	0	0	0	6890	1638	57	5	730	5	GTDC1	2	144764954	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08	35678388	144764954	98434419	26	41933											
RIF1	55183	broad.mit.edu	37	chr2	152285383	152285383	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggagcacccatgattaaaaAgatagcttttattgcttgga	13	13	9	6	0	0	2	0	1	0	1	0	4	0	4	1	2	3	3	1	2	5	6			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:152285383A>C	uc002txm.2	+	9	1002	c.872A>C	c.(871-873)AAG>ACG	p.K291T	RIF1_uc002txl.2_Missense_Mutation_p.K291T|RIF1_uc010fnv.1_Missense_Mutation_p.K255T|RIF1_uc002txn.2_Missense_Mutation_p.K291T|RIF1_uc002txo.2_Missense_Mutation_p.K291T|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	291					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		ATGATTAAAAAGATAGCTTTT	0.323													8	24					0	0	0	0	C	152285383	C	C	152285383	3	2	231	1	0	0	0	0	1	0	0	0	13424	72	3	5	902	5	RIF1	2	152285383	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	7520429	152285383	90913990	27	41934											
TANC1	85461	broad.mit.edu	37	chr2	160006935	160006935	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccacactaacaagcagcaccGcatctcctagcaccgatagc	13	5	6	17	2	1	0	0	0	1	0	2	1	1	0	4	0	5	4	4	0	4	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:160006935G>T	uc002uag.2	+	7	824	c.550G>T	c.(550-552)GCA>TCA	p.A184S	TANC1_uc010fol.1_Intron|TANC1_uc010zcm.1_Missense_Mutation_p.A183S|TANC1_uc010fom.1_Intron|TANC1_uc002uah.1_3'UTR	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	184	Ser-rich.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						AAGCAGCACCGCATCTCCTAG	0.527													16	13					1.67942e-08	2.3629e-08	1	0	T	160006935	T	T	160006935	3	4	231	1	0	0	0	0	1	0	0	0	15610	1087	38	3	568	3	TANC1	2	160006935	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	7721552	160006935	83192438	28	41935											
SCN1A	6323	broad.mit.edu	37	chr2	166894613	166894613	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	attagcatatttaacgttggCcaagattttgccaacttgaa	13	14	7	7	1	0	2	0	1	0	1	0	2	0	2	2	1	4	2	2	1	6	8			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:166894613C>A	uc010zcz.1	-	15	2604	c.2586G>T	c.(2584-2586)TGG>TGT	p.W862C	SCN1A_uc002udo.3_Missense_Mutation_p.W742C|SCN1A_uc010fpk.2_Missense_Mutation_p.W714C	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	873	Helical; Voltage-sensor; Name=S4 of repeat II; (By similarity).|II.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTAACGTTGGCCAAGATTTTG	0.373													11	75					2.80697e-09	4.04338e-09	1	0	A	166894613	A	A	166894613	3	1	231	1	0	0	0	0	1	0	0	0	13979	740	26	4	3458	4	SCN1A	2	166894613	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	6887678	166894613	76304760	29	41936											
TTN	7273	broad.mit.edu	37	chr2	179552943	179552943	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagtaactccattcctcctCtgcagatactttaaaagata	13	13	5	10	0	1	3	0	1	1	2	4	3	4	3	3	0	3	2	3	0	5	6			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:179552943C>G	uc010zfg.1	-	124	28698	c.28474G>C	c.(28474-28476)GAG>CAG	p.E9492Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E6153Q|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10419							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTCCTCCTCTGCAGATACT	0.398													19	190					0	0	0	0	G	179552943	G	G	179552943	3	3	231	1	0	0	0	0	1	0	0	0	16803	922	32	2	72267	2	TTN	2	179552943	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	12658330	179552943	63646430	30	41937											
STAT1	6772	broad.mit.edu	37	chr2	191862724	191862724	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcaactctattattttgtGaactacttcctaaaggcaat	13	14	5	9	0	1	1	0	1	1	0	2	1	2	1	1	1	4	2	1	1	8	7			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:191862724G>A	uc002usj.2	-	9	1031	c.643C>T	c.(643-645)CAC>TAC	p.H215Y	STAT1_uc010fse.1_Missense_Mutation_p.H215Y|STAT1_uc002usk.2_Missense_Mutation_p.H215Y|STAT1_uc002usl.2_Missense_Mutation_p.H217Y|STAT1_uc010fsf.1_Missense_Mutation_p.H27Y	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	215					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	ATTATTTTGTGAACTACTTCC	0.328													7	72					0	0	0	0	A	191862724	A	A	191862724	3	1	231	1	0	0	0	0	1	0	0	0	15330	1290	45	2	1681	2	STAT1	2	191862724	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	12309781	191862724	51336649	31	41938											
OBFC2A	64859	broad.mit.edu	37	chr2	192548983	192548983	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaacagaagaataattccAtgaatagtaatatgggtaca	18	10	9	4	0	0	4	0	2	0	2	1	4	1	4	1	1	2	2	1	1	9	6			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:192548983A>G	uc002usx.2	+	5	886	c.406A>G	c.(406-408)ATG>GTG	p.M136V	OBFC2A_uc002usw.2_Missense_Mutation_p.M56V|OBFC2A_uc002usy.2_RNA|OBFC2A_uc002usz.2_RNA|OBFC2A_uc002uta.2_Missense_Mutation_p.M56V	NM_001031716	NP_001026886	Q96AH0	SOSB2_HUMAN	oligonucleotide/oligosaccharide-binding fold	136					double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	single-stranded DNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.061)|Epithelial(96;0.244)			GAATAATTCCATGAATAGTAA	0.299													25	83					0	0	0	0	G	192548983	G	G	192548983	3	3	231	1	0	0	0	0	1	0	0	0	10862	217	8	5	424	5	OBFC2A	2	192548983	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	686259	192548983	50650390	32	41939											
SPATS2L	26010	broad.mit.edu	37	chr2	201303979	201303979	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caagcaagcctaaggcaaaaAcatctcctgttaagtccaat	16	8	6	11	0	1	0	0	0	1	0	3	0	2	0	3	1	3	3	3	1	7	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:201303979A>T	uc002uvn.3	+	7	932	c.580A>T	c.(580-582)ACA>TCA	p.T194S	SPATS2L_uc010fst.2_Missense_Mutation_p.T194S|SPATS2L_uc002uvo.3_Missense_Mutation_p.T134S|SPATS2L_uc002uvp.3_Missense_Mutation_p.T194S|SPATS2L_uc002uvq.3_Intron|SPATS2L_uc002uvr.3_Missense_Mutation_p.T194S|SPATS2L_uc010zhc.1_Missense_Mutation_p.T224S	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	194						cytoplasm|nucleolus				ovary(2)|pancreas(1)	3						TAAGGCAAAAACATCTCCTGT	0.443													25	21					0	0	0	0	T	201303979	T	T	201303979	3	4	231	1	0	0	0	0	1	0	0	0	15086	43	2	5	598	5	SPATS2L	2	201303979	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	8754996	201303979	41895394	33	41940											
VWC2L	402117	broad.mit.edu	37	chr2	215440475	215440475	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgtaacatctgtcattgTcacaacggggactggtggaa	12	10	12	7	1	3	0	2	0	1	0	3	3	3	2	0	4	2	1	0	4	4	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:215440475T>C	uc002vet.2	+	4	730	c.600T>C	c.(598-600)TGT>TGC	p.C200C	VWC2L_uc010zjl.1_3'UTR	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	200						extracellular region					0						TCTGTCATTGTCACAACGGGG	0.468													3	163					0	0	0	0	C	215440475	C	C	215440475	2	2	231	1	0	0	0	0	0	0	0	1	17312	1673	58	5		5	VWC2L	2	215440475	Silent	SNP	T	TCGA-CV-7235-01A-11D-2012-08	14136496	215440475	27758898	34	41941											
ANKMY1	51281	broad.mit.edu	37	chr2	241492385	241492385	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tagccttctcggtggctgagGtaaaatgtgcccgtgaaact	9	11	12	9	2	1	2	0	2	1	0	2	2	1	2	2	3	3	2	2	3	4	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr2:241492385G>A	uc002vyz.1	-	3	388	c.159C>T	c.(157-159)TAC>TAT	p.Y53Y	ANKMY1_uc002vza.1_Silent_p.Y142Y|ANKMY1_uc010fzd.1_Silent_p.Y142Y|ANKMY1_uc002vzb.1_Silent_p.Y142Y|ANKMY1_uc002vzc.1_Silent_p.Y142Y|ANKMY1_uc002vzd.1_Silent_p.Y142Y|ANKMY1_uc010fze.1_Intron|ANKMY1_uc002vze.2_Silent_p.Y44Y|ANKMY1_uc002vzf.2_Silent_p.Y44Y	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	53							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GGTGGCTGAGGTAAAATGTGC	0.567													36	56					0	0	0	0	A	241492385	A	A	241492385	2	1	231	1	0	0	0	0	0	0	0	1	634	1256	44	4		4	ANKMY1	2	241492385	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	26051910	241492385	1706988	35	41942											
CMTM8	152189	broad.mit.edu	37	chr3	32398887	32398887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggggctgctggtatggaCgcttattgctggaactgagt	6	13	15	7	1	1	1	0	1	1	0	1	3	1	3	0	5	3	5	0	5	3	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr3:32398887C>T	uc003cex.2	+	2	464	c.170C>T	c.(169-171)ACG>ATG	p.T57M	CMTM8_uc010hfu.2_Intron	NM_178868	NP_849199	Q8IZV2	CKLF8_HUMAN	CKLF-like MARVEL transmembrane domain containing	57	Helical; (Potential).|MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0						CTGGTATGGACGCTTATTGCT	0.483													22	60					0	0	0	0	T	32398887	T	T	32398887	3	4	231	1	0	0	0	0	1	0	0	0	3604	536	19	1	176	1	CMTM8	3	32398887	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08		32398887	165623543	36	41943											
ADAMTS9	56999	broad.mit.edu	37	chr3	64641512	64641512	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttcacaataacaatattaaTtaaatttccaatacttgggt	16	15	4	6	0	1	0	1	0	0	0	2	0	2	0	1	1	2	1	1	1	9	8			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr3:64641512T>G	uc003dmg.2	-	5	1041	c.1009A>C	c.(1009-1011)ATT>CTT	p.I337L	ADAMTS9_uc011bfo.1_Intron|ADAMTS9_uc003dmh.1_Missense_Mutation_p.I166L|ADAMTS9_uc003dmk.1_Missense_Mutation_p.I337L	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	337	Peptidase M12B.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ACAATATTAATTAAATTTCCA	0.294													18	6					0	0	0	0	G	64641512	G	G	64641512	3	3	231	1	0	0	0	0	1	0	0	0	273	1493	52	5	4938	5	ADAMTS9	3	64641512	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08	32242625	64641512	133380918	37	41944											
ABLIM2	84448	broad.mit.edu	37	chr4	8009911	8009911	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatcccccttgagcatcAgccagctgctcttctgctga	6	11	8	16	0	3	2	1	2	2	0	4	2	4	2	3	0	6	5	3	0	0	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr4:8009911A>G	uc003gko.2	-	15	1534	c.1391T>C	c.(1390-1392)CTG>CCG	p.L464P	ABLIM2_uc003gkk.2_Missense_Mutation_p.L128P|ABLIM2_uc003gkl.2_Missense_Mutation_p.L192P|ABLIM2_uc003gkj.3_Missense_Mutation_p.L498P|ABLIM2_uc003gkm.3_Missense_Mutation_p.L412P|ABLIM2_uc003gkp.2_Missense_Mutation_p.L423P|ABLIM2_uc003gkq.2_Missense_Mutation_p.L464P|ABLIM2_uc003gkr.2_Missense_Mutation_p.L413P|ABLIM2_uc003gks.3_Missense_Mutation_p.L424P|MIR95_hsa-mir-95|MI0000097_5'Flank	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	464					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3						CTTGAGCATCAGCCAGCTGCT	0.527													3	73					0	0	0	0	G	8009911	G	G	8009911	3	3	231	1	0	0	0	0	1	0	0	0	95	188	7	5	485	5	ABLIM2	4	8009911	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08		8009911	183144365	38	41945											
HERC3	8916	broad.mit.edu	37	chr4	89583677	89583677	+	Silent	SNP	C	T	T																															gcagtttggagacaaaaactCtcagaacacaacaatgcaaa																										TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr4:89583677C>T	uc003hrw.1	+	11	1408	c.1242C>T	c.(1240-1242)CTC>CTT	p.L414L	HERC3_uc011cdn.1_Silent_p.L296L|HERC3_uc011cdo.1_Intron	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	414					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		GACAAAAACTCTCAGAACACA	0.343													5	32					0	0	0	0	T	89583677	T	T	89583677	2	4	231	1	0	0	0	0	0	0	0	1	7098	900	32	2		2	HERC3	4	89583677	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	81573766	89583677	101570599	39	41946	87	2									
HERC3	8916	broad.mit.edu	37	chr4	89583679	89583679	+	Missense_Mutation	SNP	C	T	T																															agtttggagacaaaaactctCagaacacaacaatgcaaata																										TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr4:89583679C>T	uc003hrw.1	+	11	1410	c.1244C>T	c.(1243-1245)TCA>TTA	p.S415L	HERC3_uc011cdn.1_Missense_Mutation_p.S297L|HERC3_uc011cdo.1_Intron	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	415					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		CAAAAACTCTCAGAACACAAC	0.348													5	33					0	0	0	0	T	89583679	T	T	89583679	3	4	231	1	0	0	0	0	1	0	0	0	7098	838	29	2	1278	2	HERC3	4	89583679	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	2	89583679	101570597	40	41947	87	2									
UNC5C	8633	broad.mit.edu	37	chr4	96140364	96140364	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtggatccagaattggagaGttggtcattgggattttgtc	9	14	14	4	0	1	2	1	0	0	2	3	5	2	4	1	4	0	1	1	4	1	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr4:96140364G>C	uc003htp.1	-	9	1555	c.1401C>G	c.(1399-1401)AAC>AAG	p.N467K	UNC5C_uc010ilc.1_Missense_Mutation_p.N486K|UNC5C_uc003htq.2_Missense_Mutation_p.N486K	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	467	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GAATTGGAGAGTTGGTCATTG	0.522													56	259					0	0	0	0	C	96140364	C	C	96140364	3	2	231	1	0	0	0	0	1	0	0	0	17061	1020	36	4	1426	4	UNC5C	4	96140364	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	6556685	96140364	95013912	41	41948											
ELOVL6	79071	broad.mit.edu	37	chr4	110980841	110980841	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaaaccctggtcacaaacTgactgcttcaggcctttggt	11	11	8	11	0	2	1	2	1	0	0	2	1	2	1	2	3	3	1	2	3	4	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr4:110980841T>G	uc003hzz.2	-	4	417	c.291A>C	c.(289-291)TCA>TCC	p.S97S	ELOVL6_uc003iaa.2_Silent_p.S97S	NM_001130721	NP_001124193	Q9H5J4	ELOV6_HUMAN	elongation of very long chain fatty acids-like	97					fatty acid elongation, saturated fatty acid|long-chain fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process		fatty acid elongase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00462)		GGTCACAAACTGACTGCTTCA	0.413													10	40					0	0	0	0	G	110980841	G	G	110980841	2	3	231	1	0	0	0	0	0	0	0	1	5102	1567	55	5		5	ELOVL6	4	110980841	Silent	SNP	T	TCGA-CV-7235-01A-11D-2012-08	14840477	110980841	80173435	42	41949											
ANK2	287	broad.mit.edu	37	chr4	114095604	114095604	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaagcttcctccgtgctgcCagagcaggcaacctggacaa	10	6	11	14	1	0	1	0	0	0	1	2	2	2	2	4	2	5	5	4	2	3	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr4:114095604C>A	uc003ibe.3	+	2	217	c.117C>A	c.(115-117)GCC>GCA	p.A39A	ANK2_uc003ibd.3_Silent_p.A18A|ANK2_uc003ibf.3_Silent_p.A39A|ANK2_uc003ibc.2_Silent_p.A15A|ANK2_uc011cgb.1_Silent_p.A54A	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	39	ANK 1.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCCGTGCTGCCAGAGCAGGCA	0.433													6	31					0.000157383	0.000212775	1	0	A	114095604	A	A	114095604	2	1	231	1	0	0	0	0	0	0	0	1	621	581	21	4		4	ANK2	4	114095604	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	3114763	114095604	77058672	43	41950											
PDE5A	8654	broad.mit.edu	37	chr4	120427082	120427082	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taagttcaaaaaattctcctCgcctcctacaatgtttaaaa	15	13	3	10	1	2	0	1	0	1	0	5	0	3	0	3	0	1	2	3	0	8	6			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr4:120427082C>T	uc003idh.2	-	17	2350	c.2195G>A	c.(2194-2196)CGA>CAA	p.R732Q	uc003ide.3_Intron|PDE5A_uc003idf.2_Missense_Mutation_p.R690Q|PDE5A_uc003idg.2_Missense_Mutation_p.R680Q	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	732	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	AAATTCTCCTCGCCTCCTACA	0.318													6	39					0	0	0	0	T	120427082	T	T	120427082	3	4	231	1	0	0	0	0	1	0	0	0	11698	884	31	1	452	1	PDE5A	4	120427082	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	6331478	120427082	70727194	44	41951											
PLEKHG4B	153478	broad.mit.edu	37	chr5	140744	140744	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcccaccactcagcaggcTccaggcctgggggccaccta	7	5	10	19	0	1	0	1	0	0	0	3	0	3	0	7	4	1	2	7	4	1	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr5:140744T>C	uc003jak.2	+	1	372	c.322T>C	c.(322-324)TCC>CCC	p.S108P		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	108					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CTCAGCAGGCTCCAGGCCTGG	0.647													10	63					0	0	0	0	C	140744	C	C	140744	3	2	231	1	0	0	0	0	1	0	0	0	12127	1551	54	5	324	5	PLEKHG4B	5	140744	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08		140744	180774516	45	41952											
ADCY2	108	broad.mit.edu	37	chr5	7757570	7757570	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcttctcctagcaatgcagCaaaaaagcctctcccctgct	10	10	5	16	0	3	0	0	0	3	0	5	0	3	0	4	0	5	4	4	0	5	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr5:7757570C>A	uc003jdz.1	+	16	2032	c.1965C>A	c.(1963-1965)AGC>AGA	p.S655R	ADCY2_uc011cmo.1_Missense_Mutation_p.S475R	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	655					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AGCAATGCAGCAAAAAAGCCT	0.488													73	98					2.40655e-23	3.75733e-23	1	0	A	7757570	A	A	7757570	3	1	231	1	0	0	0	0	1	0	0	0	294	709	25	4	2027	4	ADCY2	5	7757570	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	7616826	7757570	173157690	46	41953											
SEMA5A	9037	broad.mit.edu	37	chr5	9066619	9066619	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccagcaaattcggatcaGccaggcgggctttgcatgtg	8	10	12	11	2	1	0	1	0	0	0	3	1	2	1	2	3	3	3	2	3	1	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr5:9066619G>T	uc003jek.2	-	17	2925	c.2213C>A	c.(2212-2214)GCT>GAT	p.A738D		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	738	TSP type-1 4.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						ATTCGGATCAGCCAGGCGGGC	0.542													32	150					9.78306e-22	1.51763e-21	1	0	T	9066619	T	T	9066619	3	4	231	1	0	0	0	0	1	0	0	0	14102	971	34	4	1039	4	SEMA5A	5	9066619	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	1309049	9066619	171848641	47	41954											
ANKH	56172	broad.mit.edu	37	chr5	14758660	14758660	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttgctccccaccgactcgtCcacatggtgcagtttattga	7	12	8	14	2	0	1	0	1	0	0	3	2	2	1	4	1	2	3	4	1	1	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr5:14758660C>T	uc003jfm.3	-	3	692	c.361G>A	c.(361-363)GAC>AAC	p.D121N		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	121	Extracellular (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						ACCGACTCGTCCACATGGTGC	0.433													12	63					0	0	0	0	T	14758660	T	T	14758660	3	4	231	1	0	0	0	0	1	0	0	0	627	855	30	2	1157	2	ANKH	5	14758660	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	5692041	14758660	166156600	48	41955											
ITGA1	3672	broad.mit.edu	37	chr5	52201636	52201636	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttcttctggagatgtgctCtatattgctggacagcctcg	6	14	11	10	1	3	1	0	0	3	1	4	3	3	2	1	2	3	3	1	2	2	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr5:52201636C>G	uc003jou.2	+	12	1405	c.1353C>G	c.(1351-1353)CTC>CTG	p.L451L	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_5'UTR	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	451	FG-GAP 4.|Extracellular (Potential).				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GAGATGTGCTCTATATTGCTG	0.433													14	37					0	0	0	0	G	52201636	G	G	52201636	2	3	231	1	0	0	0	0	0	0	0	1	7911	900	32	2		2	ITGA1	5	52201636	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	37442976	52201636	128713624	49	41956											
MAST4	375449	broad.mit.edu	37	chr5	66459360	66459360	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtccgaggagaagctgtcGccctcttacggcagtgacaa	10	7	12	12	3	1	2	0	1	1	1	3	4	2	2	2	2	2	2	2	2	3	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr5:66459360G>A	uc003jut.1	+	28	3854	c.3786G>A	c.(3784-3786)TCG>TCA	p.S1262S	MAST4_uc003juw.2_Silent_p.S1190S|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1454						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGAAGCTGTCGCCCTCTTACG	0.667													10	12					0	0	0	0	A	66459360	A	A	66459360	2	1	231	1	0	0	0	0	0	0	0	1	9380	1074	38	1		1	MAST4	5	66459360	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	14257724	66459360	114455900	50	41957											
TGFBI	7045	broad.mit.edu	37	chr5	135388800	135388801	+	Frame_Shift_Del	DEL	CA	-	-																															cattgatgagctactcatccCagactcaggtaggccaggcc																										TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr5:135388800_135388801delCA	uc003lbf.3	+	8	1279_1280	c.1118_1119delCA	c.(1117-1119)CCAfs	p.P373fs	TGFBI_uc003lbg.3_Frame_Shift_Del_p.P106fs|TGFBI_uc003lbh.3_Frame_Shift_Del_p.P199fs|TGFBI_uc011cyb.1_Frame_Shift_Del_p.P199fs|TGFBI_uc010jed.2_Frame_Shift_Del_p.P106fs	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	373					angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTACTCATCCCAGACTCAGGTA	0.569													---	---	---								-	135388801	-	-	135388800	7	5	231	1	0	1	0	1	0	0	0	0	15886	594	21	0	1148	0	TGFBI	5	135388800	Frame_Shift_Del	DEL	CA	TCGA-CV-7235-01A-11D-2012-08	68929440	135388800	45526460	51	41958											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139903729	139903729	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agagaaaaaagaaaaaagagGaacagaaaaggaaacaggaa	28	0	11	2	0	0	4	0	0	0	4	0	8	0	7	0	3	2	0	0	3	11	0			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr5:139903729G>T	uc003lfs.1	+	25	4520	c.4396G>T	c.(4396-4398)GAA>TAA	p.E1466*	ANKHD1_uc003lfq.1_Nonsense_Mutation_p.E1485*|ANKHD1_uc003lfr.2_Nonsense_Mutation_p.E1466*|ANKHD1_uc003lft.1_Nonsense_Mutation_p.E677*|ANKHD1_uc003lfu.1_Nonsense_Mutation_p.E946*|ANKHD1_uc003lfv.1_Nonsense_Mutation_p.E543*|ANKHD1-EIF4EBP3_uc011czh.1_Nonsense_Mutation_p.E205*|ANKHD1_uc003lfw.2_Nonsense_Mutation_p.E104*|ANKHD1_uc010jfl.2_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1466						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			gaaaaaagaggaacagaaaag	0.299													9	14					1.76689e-08	2.47161e-08	1	0	T	139903729	T	T	139903729	4	4	231	1	0	0	0	0	0	1	0	0	629	1175	41	2	4494	2	ANKHD1-EIF4EBP3	5	139903729	Nonsense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	4514929	139903729	41011531	52	41959											
MSX2	4488	broad.mit.edu	37	chr5	174156337	174156337	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacctcacagagacccaGgtcaaaatctggttccagaa	14	7	8	12	0	3	3	2	1	1	2	4	4	4	3	3	2	1	1	3	2	4	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr5:174156337G>T	uc003mcy.2	+	2	643	c.555G>T	c.(553-555)CAG>CAT	p.Q185H		NM_002449	NP_002440	P35548	MSX2_HUMAN	msh homeobox 2	185	Homeobox.				cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CAGAGACCCAGGTCAAAATCT	0.547													13	58					4.36969e-10	6.37027e-10	1	0	T	174156337	T	T	174156337	3	4	231	1	0	0	0	0	1	0	0	0	9949	991	35	4	561	4	MSX2	5	174156337	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	34252608	174156337	6758923	53	41960											
DSP	1832	broad.mit.edu	37	chr6	7585071	7585071	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtagatagaaagacaggcAgtcagtatgatattcaagat	16	10	11	4	0	2	5	2	1	0	4	2	5	2	5	0	2	0	3	0	2	6	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:7585071A>G	uc003mxp.1	+	24	7855	c.7576A>G	c.(7576-7578)AGT>GGT	p.S2526G	DSP_uc003mxq.1_Missense_Mutation_p.S1927G	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2526	Plectin 13.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAAGACAGGCAGTCAGTATGA	0.473													24	90					0	0	0	0	G	7585071	G	G	7585071	3	3	231	1	0	0	0	0	1	0	0	0	4803	188	7	5	7670	5	DSP	6	7585071	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08		7585071	163529996	54	41961											
GCNT2	2651	broad.mit.edu	37	chr6	10529730	10529730	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acacctgcgggcaagactttCccctgaaaaccaacagggaa	14	5	9	13	1	0	2	0	1	0	1	1	3	1	3	4	2	3	1	4	2	5	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:10529730C>T	uc010joo.2	+	3	1137	c.586C>T	c.(586-588)CCC>TCC	p.P196S	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Missense_Mutation_p.P195S|GCNT2_uc010jon.2_Missense_Mutation_p.P195S	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	196	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		GCAAGACTTTCCCCTGAAAAC	0.532													38	34					0	0	0	0	T	10529730	T	T	10529730	3	4	231	1	0	0	0	0	1	0	0	0	6336	855	30	2	588	2	GCNT2	6	10529730	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	2944659	10529730	160585337	55	41962											
BTN1A1	696	broad.mit.edu	37	chr6	26505323	26505323	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcctgatgaagaaggtttgTtcactgtggctgcttcagtg	8	14	12	7	0	2	3	2	2	0	1	3	3	3	3	1	2	1	4	1	2	2	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:26505323T>C	uc003nif.3	+	3	618	c.598T>C	c.(598-600)TTC>CTC	p.F200L		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	200	Extracellular (Potential).|Ig-like V-type 2.					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						AGAAGGTTTGTTCACTGTGGC	0.478													12	71					0	0	0	0	C	26505323	C	C	26505323	3	2	231	1	0	0	0	0	1	0	0	0	1564	1725	60	5	608	5	BTN1A1	6	26505323	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08	15975593	26505323	144609744	56	41963											
ZNF322A	79692	broad.mit.edu	37	chr6	26638669	26638669	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actggtatatatgaccatctAtctgaataatctcatgcata	14	14	5	8	0	3	2	1	2	3	0	4	2	3	2	1	1	1	2	1	1	7	6			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:26638669A>G	uc003nil.3	-	4	742	c.113T>C	c.(112-114)ATA>ACA	p.I38T	ZNF322A_uc003nij.2_5'Flank	NM_024639	NP_078915	Q6U7Q0	Z322A_HUMAN	zinc finger protein 322A	38					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0						ATGACCATCTATCTGAATAAT	0.343													37	179					0	0	0	0	G	26638669	G	G	26638669	3	3	231	1	0	0	0	0	1	0	0	0	17908	449	16	5	1099	5	ZNF322A	6	26638669	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	133346	26638669	144476398	57	41964											
PGBD1	84547	broad.mit.edu	37	chr6	28251760	28251760	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgctaccaggaggctcacgGaccccaggaagctctggccc	8	5	12	16	1	2	0	1	0	1	0	2	3	2	3	4	5	3	3	4	5	2	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:28251760G>A	uc003nky.2	+	2	540	c.170G>A	c.(169-171)GGA>GAA	p.G57E	PGBD1_uc003nkz.2_Missense_Mutation_p.G57E	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	57	SCAN box.				viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						GAGGCTCACGGACCCCAGGAA	0.587													53	52					0	0	0	0	A	28251760	A	A	28251760	3	1	231	1	0	0	0	0	1	0	0	0	11835	1174	41	2	172	2	PGBD1	6	28251760	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	1613091	28251760	142863307	58	41965											
HLA-G	3135	broad.mit.edu	37	chr6	29796426	29796426	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaaggattacctcgccctGaacgaggacctgcgctcctg	8	7	12	14	3	0	1	0	1	0	0	2	4	1	3	4	3	3	2	4	3	3	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:29796426G>T	uc003nnw.2	+	4	628	c.450G>T	c.(448-450)CTG>CTT	p.L150L	HLA-G_uc011dmb.1_Silent_p.L122L|HLA-G_uc003raj.3_Silent_p.L155L|HLA-G_uc003nnz.3_Intron|HLA-G_uc010jrn.2_Intron|HLA-G_uc003nny.3_Intron|HLA-G_uc003ran.1_5'Flank	NM_002127	NP_002118	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	150	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			ovary(3)|central_nervous_system(1)	4						ACCTCGCCCTGAACGAGGACC	0.617													22	94					3.8784e-16	5.97818e-16	1	0	T	29796426	T	T	29796426	2	4	231	1	0	0	0	0	0	0	0	1	7251	1277	45	2		2	HLA-G	6	29796426	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	1544666	29796426	141318641	59	41966											
FLOT1	10211	broad.mit.edu	37	chr6	30698343	30698343	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctcagcttccccacgcatCtgagggttaaggatgcttgt	7	11	11	12	1	2	1	1	1	1	0	3	2	3	2	3	2	2	4	3	2	1	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:30698343C>G	uc003nrm.2	-	11	1116	c.952_splice	c.e11-1	p.M318_splice	FLOT1_uc011dmr.1_Splice_Site_p.M270_splice	NM_005803	NP_005794	O75955	FLOT1_HUMAN	flotillin 1							centriolar satellite|endosome|integral to membrane|melanosome|membrane fraction					0						CCCCACGCATCTGAGGGTTAA	0.562													43	183					0	0	0	0	G	30698343	G	G	30698343	5	3	231	1	0	0	0	0	0	0	1	0	5968	927	32	2	344	2	FLOT1	6	30698343	Splice_Site	SNP	C	TCGA-CV-7235-01A-11D-2012-08	901917	30698343	140416724	60	41967											
GRM4	2914	broad.mit.edu	37	chr6	34101096	34101096	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcttgccctctgagccccGgccatgcaccgggaacaggc	6	5	14	16	2	1	1	0	1	1	0	1	2	1	2	5	4	4	2	5	4	1	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:34101096G>A	uc003oir.3	-	1	348	c.178C>T	c.(178-180)CGG>TGG	p.R60W	GRM4_uc011dsn.1_Missense_Mutation_p.R60W|GRM4_uc010jvh.2_Missense_Mutation_p.R60W|GRM4_uc010jvi.2_5'UTR|GRM4_uc010jvk.1_5'UTR	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	60	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	TCTGAGCCCCGGCCATGCACC	0.597													6	40					0	0	0	0	A	34101096	A	A	34101096	3	1	231	1	0	0	0	0	1	0	0	0	6838	1115	39	1	2600	1	GRM4	6	34101096	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	3402753	34101096	137013971	61	41968											
RPL10A	4736	broad.mit.edu	37	chr6	35436736	35436736	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctcgaaggttcctggagacGgtggagttgcagatcagctt	8	11	14	8	2	2	2	1	0	1	2	4	5	3	3	1	4	2	4	1	4	1	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:35436736G>T	uc003okp.1	+	3	127	c.93G>T	c.(91-93)ACG>ACT	p.T31T	RPL10A_uc003okq.1_5'UTR|RPL10A_uc003okr.1_5'UTR|RPL10A_uc003oks.1_5'UTR	NM_007104	NP_009035	P62906	RL10A_HUMAN	ribosomal protein L10a	31					anatomical structure morphogenesis|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	RNA binding|structural constituent of ribosome			ovary(1)	1						TCCTGGAGACGGTGGAGTTGC	0.647													18	19					1.01871e-10	1.50322e-10	1	0	T	35436736	T	T	35436736	2	4	231	1	0	0	0	0	0	0	0	1	13620	1103	39	3		3	RPL10A	6	35436736	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	1335640	35436736	135678331	62	41969											
BRPF3	27154	broad.mit.edu	37	chr6	36175199	36175199	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattgagctgattcggaagaGagagaagctcaaacgagagc	15	6	14	6	2	1	5	1	2	0	3	2	10	1	6	0	1	4	2	0	1	3	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:36175199G>A	uc003olv.3	+	4	1939	c.1715G>A	c.(1714-1716)AGA>AAA	p.R572K	BRPF3_uc010jwb.2_Missense_Mutation_p.R572K|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Missense_Mutation_p.R572K	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	572					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						ATTCGGAAGAGAGAGAAGCTC	0.537													5	35					0	0	0	0	A	36175199	A	A	36175199	3	1	231	1	0	0	0	0	1	0	0	0	1526	942	33	2	1725	2	BRPF3	6	36175199	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	738463	36175199	134939868	63	41970											
LMBRD1	55788	broad.mit.edu	37	chr6	70386390	70386390	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagcagcactgaagaaccaGaacttgtgaaggaataggta	17	7	11	6	0	0	4	0	2	0	2	0	5	0	5	1	2	4	3	1	2	8	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:70386390G>A	uc003pfa.2	-	15	1576	c.1461C>T	c.(1459-1461)TTC>TTT	p.F487F	LMBRD1_uc003pey.2_Silent_p.F283F|LMBRD1_uc003pez.2_Silent_p.F414F|LMBRD1_uc010kal.2_Silent_p.F414F|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	487	Helical; Name=9; (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						TGAAGAACCAGAACTTGTGAA	0.383													4	24					0	0	0	0	A	70386390	A	A	70386390	2	1	231	1	0	0	0	0	0	0	0	1	8884	933	33	2		2	LMBRD1	6	70386390	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	34211191	70386390	100728677	64	41971											
ROS1	6098	broad.mit.edu	37	chr6	117641132	117641132	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttcccagcaagagacgcaGagtcagtttttcccgaggga	11	8	11	11	2	1	2	1	0	0	2	3	5	3	3	2	1	1	3	2	1	1	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:117641132G>C	uc003pxp.1	-	36	6038	c.5839C>G	c.(5839-5841)CTG>GTG	p.L1947V	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Missense_Mutation_p.L273V	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1947	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AAGAGACGCAGAGTCAGTTTT	0.463			T	GOPC|ROS1	glioblastoma|NSCLC								17	35					0	0	0	0	C	117641132	C	C	117641132	3	2	231	1	0	0	0	0	1	0	0	0	13596	933	33	2	1236	2	ROS1	6	117641132	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	47254742	117641132	53473935	65	41972											
LRP11	84918	broad.mit.edu	37	chr6	150174187	150174187	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcagtgcccactcatactgGacgatggcgtggtcatctgt	8	10	12	11	2	3	0	2	0	1	0	3	2	3	1	1	3	3	1	1	3	1	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:150174187G>A	uc003qng.2	-	2	1047	c.723C>T	c.(721-723)GTC>GTT	p.V241V	LRP11_uc003qnh.1_Silent_p.V241V	NM_032832	NP_116221	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein	241	PKD.|Extracellular (Potential).					integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		ACTCATACTGGACGATGGCGT	0.562													20	39					0	0	0	0	A	150174187	A	A	150174187	2	1	231	1	0	0	0	0	0	0	0	1	9003	1161	41	2		2	LRP11	6	150174187	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	32533055	150174187	20940880	66	41973											
ZBTB2	57621	broad.mit.edu	37	chr6	151694704	151694704	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgcaaccgtgcagtcacaCaggaaaccaaactctcgctg	13	7	8	13	2	2	0	1	0	1	0	3	1	2	1	2	1	5	3	2	1	3	1	rs142578824		TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:151694704C>T	uc003qoh.2	-	2	204	c.69G>A	c.(67-69)CTG>CTA	p.L23L		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	23					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		TGCAGTCACACAGGAAACCAA	0.388													7	32					0	0	0	0	T	151694704	T	T	151694704	2	4	231	1	0	0	0	0	0	0	0	1	17595	465	17	4		4	ZBTB2	6	151694704	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	1520517	151694704	19420363	67	41974											
PHF10	55274	broad.mit.edu	37	chr6	170112526	170112526	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcatcacctcgaccatcttCgccatcatctgaatcaccat	10	11	3	17	2	6	1	4	1	2	0	8	2	6	1	4	0	0	0	4	0	1	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr6:170112526C>T	uc011egy.1	-	8	992	c.913G>A	c.(913-915)GAA>AAA	p.E305K	PHF10_uc011egz.1_Missense_Mutation_p.E303K|PHF10_uc011eha.1_Missense_Mutation_p.E156K	NM_018288	NP_060758	Q8WUB8	PHF10_HUMAN	PHD finger protein 10 isoform a	305	Essential to induce neural progenitor proliferation (By similarity).				nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	npBAF complex	zinc ion binding			urinary_tract(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.4e-21)|BRCA - Breast invasive adenocarcinoma(81;1.4e-07)|GBM - Glioblastoma multiforme(31;0.00176)		CGACCATCTTCGCCATCATCT	0.458													18	57					0	0	0	0	T	170112526	T	T	170112526	3	4	231	1	0	0	0	0	1	0	0	0	11876	893	31	1	603	1	PHF10	6	170112526	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	18417822	170112526	1002541	68	41975											
CYP2W1	54905	broad.mit.edu	37	chr7	1026395	1026395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtgtgcccgggggaccccGtgtgcagctatgtggacgcc	5	7	16	13	4	0	0	0	0	0	0	0	2	0	2	4	3	3	2	4	3	1	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:1026395G>A	uc003sjq.1	+	5	794	c.781G>A	c.(781-783)GTG>ATG	p.V261M	CYP2W1_uc003sjr.1_Missense_Mutation_p.V261M	NM_017781	NP_060251	Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W,	261					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GGGGGACCCCGTGTGCAGCTA	0.682													7	28					0	0	0	0	A	1026395	A	A	1026395	3	1	231	1	0	0	0	0	1	0	0	0	4193	1145	40	1	799	1	CYP2W1	7	1026395	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08		1026395	158112268	69	41976											
TRA2A	29896	broad.mit.edu	37	chr7	23561386	23561386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggaaacccttgatggactaCgagatcctgacctgctctcc	9	10	9	13	1	1	3	0	2	1	1	3	6	2	5	4	2	3	1	4	2	2	2	rs142235949		TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:23561386C>T	uc003swi.2	-	2	324	c.110G>A	c.(109-111)CGT>CAT	p.R37H	TRA2A_uc011jzb.1_RNA|TRA2A_uc011jzc.1_5'UTR|TRA2A_uc011jzd.1_5'UTR|TRA2A_uc010kuo.1_RNA	NM_013293	NP_037425	Q13595	TRA2A_HUMAN	transformer-2 alpha	37	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TGATGGACTACGAGATCCTGA	0.413													28	44					0	0	0	0	T	23561386	T	T	23561386	3	4	231	1	0	0	0	0	1	0	0	0	16500	536	19	1	766	1	TRA2A	7	23561386	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	22534991	23561386	135577277	70	41977											
PCLO	27445	broad.mit.edu	37	chr7	82545296	82545296	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactattgtacttactaccAagatgggaaacagcaaatgt	17	10	7	7	0	0	1	0	0	0	1	0	2	0	2	1	1	6	2	1	1	8	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:82545296A>G	uc003uhx.2	-	7	12295	c.12006T>C	c.(12004-12006)CTT>CTC	p.L4002L	PCLO_uc003uhv.2_Silent_p.L4002L|PCLO_uc010lec.2_Silent_p.L967L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3933					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACTTACTACCAAGATGGGAAA	0.398													141	174					0	0	0	0	G	82545296	G	G	82545296	2	3	231	1	0	0	0	0	0	0	0	1	11637	117	5	5		5	PCLO	7	82545296	Silent	SNP	A	TCGA-CV-7235-01A-11D-2012-08	58983910	82545296	76593367	71	41978											
STEAP2	261729	broad.mit.edu	37	chr7	89854672	89854672	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaaatataatatttgttgcTatacacagagaacattatac	18	13	4	6	0	0	1	0	0	0	1	0	2	0	1	0	0	4	2	0	0	9	9			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:89854672T>C	uc003ujz.2	+	2	669	c.276T>C	c.(274-276)GCT>GCC	p.A92A	STEAP2_uc003ujy.2_Silent_p.A134A|STEAP2_uc010len.2_Silent_p.A92A|STEAP2_uc003uka.2_Silent_p.A92A|STEAP2_uc003ukb.2_Silent_p.A92A|STEAP2_uc003ukc.2_Silent_p.A92A|STEAP2_uc003ukd.2_Silent_p.A92A	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	92					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					TATTTGTTGCTATACACAGAG	0.378													55	59					0	0	0	0	C	89854672	C	C	89854672	2	2	231	1	0	0	0	0	0	0	0	1	15344	1509	53	5		5	STEAP2	7	89854672	Silent	SNP	T	TCGA-CV-7235-01A-11D-2012-08	7309376	89854672	69283991	72	41979											
CDK14	5218	broad.mit.edu	37	chr7	90547015	90547015	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	accttctgatcagtgacacgGgggagttaaagctggcagat	11	9	13	8	1	2	3	1	2	1	1	2	4	2	4	1	3	1	3	1	3	2	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:90547015G>T	uc003uky.2	+	8	1024	c.802G>T	c.(802-804)GGG>TGG	p.G268W	CDK14_uc003ukz.1_Missense_Mutation_p.G250W|CDK14_uc010les.1_Missense_Mutation_p.G222W|CDK14_uc011khl.1_Missense_Mutation_p.G139W	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	268	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						CAGTGACACGGGGGAGTTAAA	0.443													18	95					2.35188e-11	3.49175e-11	1	0	T	90547015	T	T	90547015	3	4	231	1	0	0	0	0	1	0	0	0	3145	1232	43	4	774	4	CDK14	7	90547015	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	692343	90547015	68591648	73	41980											
SAMD9L	219285	broad.mit.edu	37	chr7	92761382	92761382	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagaaaagttctgtgtatttCctgaaacaacgactgacttt	13	13	7	8	1	1	3	0	2	1	1	2	4	2	3	1	0	2	2	1	0	5	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:92761382C>T	uc003umh.1	-	5	5119	c.3903G>A	c.(3901-3903)AGG>AGA	p.R1301R	SAMD9L_uc003umj.1_Silent_p.R1301R|SAMD9L_uc003umi.1_Silent_p.R1301R|SAMD9L_uc010lfb.1_Silent_p.R1301R|SAMD9L_uc003umk.1_Silent_p.R1301R|SAMD9L_uc010lfc.1_Silent_p.R1301R|SAMD9L_uc010lfd.1_Silent_p.R1301R|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1301										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CTGTGTATTTCCTGAAACAAC	0.343													23	51					0	0	0	0	T	92761382	T	T	92761382	2	4	231	1	0	0	0	0	0	0	0	1	13892	854	30	2		2	SAMD9L	7	92761382	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	2214367	92761382	66377281	74	41981											
ARPC1B	10095	broad.mit.edu	37	chr7	98984357	98984357	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcatatctatgaaaagagCggtgccaaatggaccaaggt	14	8	12	7	1	1	2	0	1	1	1	1	3	1	3	2	3	3	1	2	3	6	2	rs144704984		TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:98984357C>T	uc003upz.2	+	3	203	c.114C>T	c.(112-114)AGC>AGT	p.S38S	ARPC1A_uc011kit.1_RNA|ARPC1B_uc003uqa.2_Silent_p.S38S|ARPC1B_uc003uqb.2_Silent_p.S38S|ARPC1B_uc003uqc.2_Silent_p.S38S	NM_005720	NP_005711	O15143	ARC1B_HUMAN	actin related protein 2/3 complex subunit 1B	38	WD 1.				cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			ATGAAAAGAGCGGTGCCAAAT	0.572													26	156					0	0	0	0	T	98984357	T	T	98984357	2	4	231	1	0	0	0	0	0	0	0	1	972	767	27	1		1	ARPC1B	7	98984357	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	6222975	98984357	60154306	75	41982											
ZNF655	79027	broad.mit.edu	37	chr7	99170398	99170398	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgtgggaaaattttccatCagagctcagcccttactaga	12	12	8	9	0	2	2	2	0	0	2	3	3	3	3	2	1	3	1	2	1	5	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:99170398C>G	uc003urh.2	+	3	1060	c.667C>G	c.(667-669)CAG>GAG	p.Q223E	ZNF655_uc010lga.2_Missense_Mutation_p.Q258E|ZNF655_uc010lgc.2_Missense_Mutation_p.Q258E|ZNF655_uc003urj.2_Missense_Mutation_p.Q223E|ZNF655_uc003urk.2_Missense_Mutation_p.Q60E|ZNF655_uc010lgd.2_Missense_Mutation_p.Q60E	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	223	C2H2-type 1.				G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					AATTTTCCATCAGAGCTCAGC	0.393													5	38					0	0	0	0	G	99170398	G	G	99170398	3	3	231	1	0	0	0	0	1	0	0	0	18135	827	29	2	1204	2	ZNF655	7	99170398	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	186041	99170398	59968265	76	41983											
ZAN	7455	broad.mit.edu	37	chr7	100361512	100361512	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggccagggttctgtggacGgctggtcgacactcatggcc	5	8	17	11	2	2	0	1	0	1	0	3	2	2	1	2	7	0	2	2	7	0	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:100361512G>C	uc003uwj.2	+	21	4235	c.4070G>C	c.(4069-4071)CGG>CCG	p.R1357P	ZAN_uc003uwk.2_Missense_Mutation_p.R1357P|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Intron	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1357	VWFD 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTCTGTGGACGGCTGGTCGAC	0.602													68	79					0	0	0	0	C	100361512	C	C	100361512	3	2	231	1	0	0	0	0	1	0	0	0	17581	1116	39	3	4148	3	ZAN	7	100361512	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	1191114	100361512	58777151	77	41984											
TSGA14	95681	broad.mit.edu	37	chr7	130039885	130039885	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaaaagatcttactaggaTgatctgcaggcccttgctcc	10	11	9	11	0	3	2	1	1	2	1	4	3	4	3	2	2	3	2	2	2	4	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:130039885T>C	uc003vpz.2	-	10	1015	c.968A>G	c.(967-969)CAT>CGT	p.H323R	TSGA14_uc003vpy.2_Missense_Mutation_p.H85R|TSGA14_uc010lmf.2_Missense_Mutation_p.H120R|TSGA14_uc003vqa.2_Intron|TSGA14_uc011kpg.1_Intron	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	323					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					CTTACTAGGATGATCTGCAGG	0.368													22	100					0	0	0	0	C	130039885	C	C	130039885	3	2	231	1	0	0	0	0	1	0	0	0	16687	1464	51	5	161	5	TSGA14	7	130039885	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08	29678373	130039885	29098778	78	41985											
EPHB6	2051	broad.mit.edu	37	chr7	142564288	142564288	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccgggcatccaacagcatCacggtgtcctggccgcagcc	8	5	12	16	3	1	0	1	0	0	0	3	0	3	0	5	3	4	3	5	3	1	0			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr7:142564288C>T	uc011kst.1	+	10	2299	c.1512C>T	c.(1510-1512)ATC>ATT	p.I504I	EPHB6_uc011ksu.1_Silent_p.I504I|EPHB6_uc003wbs.2_Silent_p.I212I|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Silent_p.I212I|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	504	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CCAACAGCATCACGGTGTCCT	0.592													34	46					0	0	0	0	T	142564288	T	T	142564288	2	4	231	1	0	0	0	0	0	0	0	1	5202	816	29	2		2	EPHB6	7	142564288	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	12524403	142564288	16574375	79	41986											
TEX15	56154	broad.mit.edu	37	chr8	30695359	30695359	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttcttcatgctatttaaaTtttcctgttgtccactgaag	8	20	5	8	0	2	1	1	1	1	0	4	1	4	1	2	0	1	2	2	0	4	9			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr8:30695359T>G	uc003xil.2	-	3	7292	c.7292A>C	c.(7291-7293)AAT>ACT	p.N2431T		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2431										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GCTATTTAAATTTTCCTGTTG	0.358													47	121					0	0	0	0	G	30695359	G	G	30695359	3	3	231	1	0	0	0	0	1	0	0	0	15845	1493	52	5	1085	5	TEX15	8	30695359	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08		30695359	115668663	80	41987											
EYA1	2138	broad.mit.edu	37	chr8	72229804	72229804	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaccttgcatctggtagctgTatggtgcctgtccaggttga	6	13	13	9	0	1	1	0	1	1	0	2	2	2	1	3	3	3	5	3	3	2	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr8:72229804T>C	uc003xys.3	-	6	826	c.539A>G	c.(538-540)TAC>TGC	p.Y180C	EYA1_uc003xyr.3_Missense_Mutation_p.Y175C|EYA1_uc003xyt.3_Missense_Mutation_p.Y147C|EYA1_uc010lzf.2_Missense_Mutation_p.Y107C|EYA1_uc003xyu.2_Missense_Mutation_p.Y180C|EYA1_uc011lfe.1_Missense_Mutation_p.Y174C|EYA1_uc003xyv.2_Missense_Mutation_p.Y58C	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	180					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CTGGTAGCTGTATGGTGCCTG	0.438													45	94					0	0	0	0	C	72229804	C	C	72229804	3	2	231	1	0	0	0	0	1	0	0	0	5353	1638	57	5	1287	5	EYA1	8	72229804	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08	41534445	72229804	74134218	81	41988											
WWP1	11059	broad.mit.edu	37	chr8	87454892	87454892	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaagttttgaacccaatgtAttgcttatttgagtatgcgg	10	16	10	5	1	0	3	0	3	0	0	0	3	0	3	1	1	3	4	1	1	6	7			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr8:87454892A>G	uc003ydt.2	+	18	2163	c.1883A>G	c.(1882-1884)TAT>TGT	p.Y628C	WWP1_uc010mai.2_Missense_Mutation_p.Y404C	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	628	HECT.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						AACCCAATGTATTGCTTATTT	0.318													18	36					0	0	0	0	G	87454892	G	G	87454892	3	3	231	1	0	0	0	0	1	0	0	0	17483	449	16	5	1945	5	WWP1	8	87454892	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	15225088	87454892	58909130	82	41989											
RUNX1T1	862	broad.mit.edu	37	chr8	92972727	92972727	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaggtttcactcgctttacGgccacaattccagcaactct	9	11	7	14	2	2	0	1	0	1	0	4	0	3	0	2	2	3	4	2	2	3	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr8:92972727G>T	uc003yfd.2	-	11	1642	c.1558C>A	c.(1558-1560)CGT>AGT	p.R520S	RUNX1T1_uc003yfc.1_Missense_Mutation_p.R493S|RUNX1T1_uc003yfe.1_Missense_Mutation_p.R483S|RUNX1T1_uc010mao.2_Missense_Mutation_p.R493S|RUNX1T1_uc011lgi.1_Missense_Mutation_p.R531S|uc010mam.2_5'Flank|RUNX1T1_uc010man.1_Missense_Mutation_p.R145S|RUNX1T1_uc003yfb.1_Missense_Mutation_p.R483S	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	520	MYND-type.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CTCGCTTTACGGCCACAATTC	0.458													22	50					1.50039e-11	2.24132e-11	1	0	T	92972727	T	T	92972727	3	4	231	1	0	0	0	0	1	0	0	0	13812	1116	39	3	260	3	RUNX1T1	8	92972727	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	5517835	92972727	53391295	83	41990											
KIAA1429	25962	broad.mit.edu	37	chr8	95531705	95531705	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgatgactgtgaagatatCtgtggaagagttaattgata	14	13	12	2	0	1	6	0	4	1	2	1	7	1	7	0	1	0	1	0	1	5	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr8:95531705C>G	uc003ygo.1	-	9	2035	c.2022_splice	c.e9-1	p.R674_splice	KIAA1429_uc003ygp.2_Splice_Site_p.R674_splice|KIAA1429_uc010maz.1_Splice_Site	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1						mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GTGAAGATATCTGTGGAAGAG	0.373													10	57					0	0	0	0	G	95531705	G	G	95531705	5	3	231	1	0	0	0	0	0	0	1	0	8270	927	32	2	3535	2	KIAA1429	8	95531705	Splice_Site	SNP	C	TCGA-CV-7235-01A-11D-2012-08	2558978	95531705	50832317	84	41991											
CSMD3	114788	broad.mit.edu	37	chr8	113599348	113599348	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctggctgaaatattgattcCctttcctgcttgaacctgaa	9	15	7	10	0	1	4	0	4	1	0	3	4	3	4	3	1	2	2	3	1	4	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr8:113599348C>G	uc003ynu.2	-	23	3991	c.3832G>C	c.(3832-3834)GGA>CGA	p.G1278R	CSMD3_uc003yns.2_Missense_Mutation_p.G550R|CSMD3_uc003ynt.2_Missense_Mutation_p.G1238R|CSMD3_uc011lhx.1_Missense_Mutation_p.G1174R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1278	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATATTGATTCCCTTTCCTGCT	0.338										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			24	46					0	0	0	0	G	113599348	G	G	113599348	3	3	231	1	0	0	0	0	1	0	0	0	3963	632	22	4	7487	4	CSMD3	8	113599348	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	18067643	113599348	32764674	85	41992											
SCRIB	23513	broad.mit.edu	37	chr8	144891191	144891191	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcctctgcgaaatgcaccGtgggctgtgcggacaaaagg	9	7	14	11	4	1	0	0	0	1	0	2	2	2	1	2	3	3	2	2	3	3	0			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr8:144891191G>A	uc003yzp.1	-	15	1710	c.1703C>T	c.(1702-1704)ACG>ATG	p.T568M	SCRIB_uc003yzo.1_Missense_Mutation_p.T568M	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	568	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GAAATGCACCGTGGGCTGTGC	0.657													18	70					0	0	0	0	A	144891191	A	A	144891191	3	1	231	1	0	0	0	0	1	0	0	0	14002	1145	40	1	3356	1	SCRIB	8	144891191	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	31291843	144891191	1472831	86	41993											
RORB	6096	broad.mit.edu	37	chr9	77286707	77286707	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactctttctttcatcagacCgagcctggcttatagaacca	10	12	6	13	1	4	2	2	0	2	2	4	3	4	2	3	1	2	1	3	1	3	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr9:77286707C>A	uc004aji.2	+	9	1196	c.1147C>A	c.(1147-1149)CGA>AGA	p.R383R	RORB_uc004ajh.2_Silent_p.R372R	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	383	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						TTCATCAGACCGAGCCTGGCT	0.403													23	19					3.01185e-09	4.31282e-09	1	0	A	77286707	A	A	77286707	2	1	231	1	0	0	0	0	0	0	0	1	13594	644	23	3		3	RORB	9	77286707	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08		77286707	63926724	87	41994											
VPS13A	23230	broad.mit.edu	37	chr9	79917956	79917956	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttccttgttttaatgtaaAtgctcagctgaaaccaatgg	12	14	8	7	0	1	1	1	1	0	0	2	1	2	1	2	1	3	5	2	1	5	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr9:79917956A>G	uc004akr.2	+	34	4198	c.3938A>G	c.(3937-3939)AAT>AGT	p.N1313S	VPS13A_uc004akp.3_Missense_Mutation_p.N1313S|VPS13A_uc004akq.3_Missense_Mutation_p.N1313S|VPS13A_uc004aks.2_Missense_Mutation_p.N1274S|VPS13A_uc010mpo.1_5'UTR	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1313	TPR 5.				Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						TTTAATGTAAATGCTCAGCTG	0.378													76	37					0	0	0	0	G	79917956	G	G	79917956	3	3	231	1	0	0	0	0	1	0	0	0	17257	101	4	5	4072	5	VPS13A	9	79917956	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	2631249	79917956	61295475	88	41995											
HDHD3	81932	broad.mit.edu	37	chr9	116136605	116136605	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtccttcacatcccacgtCagcagtcgtatctgcagccg	7	10	9	15	3	3	0	2	0	1	0	6	0	5	0	3	0	3	3	3	0	1	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr9:116136605C>T	uc004bhi.1	-	2	814	c.30G>A	c.(28-30)CTG>CTA	p.L10L	HDHD3_uc004bhj.2_Silent_p.L10L|HDHD3_uc004bhk.2_Silent_p.L10L	NM_031219	NP_112496	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain	10							phosphoglycolate phosphatase activity|protein binding				0						CATCCCACGTCAGCAGTCGTA	0.657													7	40					0	0	0	0	T	116136605	T	T	116136605	2	4	231	1	0	0	0	0	0	0	0	1	7063	813	29	2		2	HDHD3	9	116136605	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	36218649	116136605	25076826	89	41996											
COL27A1	85301	broad.mit.edu	37	chr9	117044557	117044557	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtccctcctctctcttcagGgtcctgaaggaaaatcaggg	8	11	10	12	0	4	1	2	1	2	0	8	2	7	2	3	3	0	0	3	3	3	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr9:117044557G>C	uc011lxl.1	+	38	3718	c.3718G>C	c.(3718-3720)GGT>CGT	p.G1240R	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1240	Collagen-like 10.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CTCTCTTCAGGGTCCTGAAGG	0.468													70	40					0	0	0	0	C	117044557	C	C	117044557	3	2	231	1	0	0	0	0	1	0	0	0	3700	1246	43	4	3868	4	COL27A1	9	117044557	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	907952	117044557	24168874	90	41997											
TRIM32	22954	broad.mit.edu	37	chr9	119461761	119461761	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttccgctgcattgctggCatgtgtgtggatgctcgtgg	4	14	15	8	2	0	0	0	0	0	0	2	2	1	1	1	3	3	5	1	3	0	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr9:119461761C>T	uc004bjx.2	+	2	1898	c.1740C>T	c.(1738-1740)GGC>GGT	p.G580G	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Silent_p.G580G	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	580	NHL 4.				fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						GCATTGCTGGCATGTGTGTGG	0.527									Bardet-Biedl_syndrome				52	28					0	0	0	0	T	119461761	T	T	119461761	2	4	231	1	0	0	0	0	0	0	0	1	16573	697	25	4		4	TRIM32	9	119461761	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	2417204	119461761	21751670	91	41998											
PIP5KL1	138429	broad.mit.edu	37	chr9	130684360	130684360	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agccggcggttttgggctctCgactcttccgggctctgtgc	2	12	14	13	4	3	0	0	0	3	0	5	1	4	0	2	4	2	3	2	4	0	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr9:130684360C>G	uc011mao.1	-	10	996	c.951G>C	c.(949-951)TCG>TCC	p.S317S	PIP5KL1_uc004bsu.2_Silent_p.S114S	NM_001135219	NP_001128691	Q5T9C9	PI5L1_HUMAN	phosphatidylinositol-4-phosphate 5-kinase-like 1	317	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			lung(1)|kidney(1)	2						TTTGGGCTCTCGACTCTTCCG	0.677													2	7					0	0	0	0	G	130684360	G	G	130684360	2	3	231	1	0	0	0	0	0	0	0	1	11997	871	31	3		3	PIP5KL1	9	130684360	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	11222599	130684360	10529071	92	41999											
TUBB2C	10383	broad.mit.edu	37	chr9	140137606	140137606	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgccatggccgctacctgacGgttgccgccgtgttcagggg	4	8	15	14	5	1	1	1	1	0	0	1	1	1	1	5	4	2	3	5	4	1	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr9:140137606G>A	uc004cmh.1	+	4	1038	c.936G>A	c.(934-936)ACG>ACA	p.T312T	TUBB2C_uc004cmg.1_Silent_p.T166T	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	312					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GCTACCTGACGGTTGCCGCCG	0.567													4	116					0	0	0	0	A	140137606	A	A	140137606	2	1	231	1	0	0	0	0	0	0	0	1	16824	1103	39	1		1	TUBB2C	9	140137606	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	9453246	140137606	1075825	93	42000											
ANKRD26	22852	broad.mit.edu	37	chr10	27303483	27303483	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttctagatagagttgcttaTatttttccagttcggtttta	8	20	7	6	1	1	2	0	0	1	2	3	2	2	2	1	1	1	4	1	1	5	11			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr10:27303483T>C	uc001ith.2	-	31	4833	c.4661A>G	c.(4660-4662)TAT>TGT	p.Y1554C	ANKRD26_uc001itg.2_Missense_Mutation_p.Y1241C|ANKRD26_uc009xku.1_Missense_Mutation_p.Y1555C	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1554	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						GAGTTGCTTATATTTTTCCAG	0.284													17	13					0	0	0	0	C	27303483	C	C	27303483	3	2	231	1	0	0	0	0	1	0	0	0	654	1406	49	5	484	5	ANKRD26	10	27303483	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08		27303483	108231264	94	42001											
CCDC109A	90550	broad.mit.edu	37	chr10	74620189	74620189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaattttcacagatggtgttCgcgttgctgcttcaacagga	10	13	10	8	2	2	1	2	0	0	1	3	2	2	2	0	2	3	4	0	2	2	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr10:74620189C>T	uc001jtc.2	+	4	421	c.400C>T	c.(400-402)CGC>TGC	p.R134C	CCDC109A_uc009xqp.1_RNA|CCDC109A_uc009xqq.1_RNA|CCDC109A_uc010qjy.1_RNA|CCDC109A_uc009xqr.2_Missense_Mutation_p.R134C|CCDC109A_uc001jtd.2_Missense_Mutation_p.R85C	NM_138357	NP_612366	Q8NE86	MCU_HUMAN	coiled-coil domain containing 109A	134	Mitochondrial matrix (Potential).				elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding				0	Prostate(51;0.0198)					AGATGGTGTTCGCGTTGCTGC	0.358													18	77					0	0	0	0	T	74620189	T	T	74620189	3	4	231	1	0	0	0	0	1	0	0	0	2756	884	31	1	414	1	CCDC109A	10	74620189	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	47316706	74620189	60914558	95	42002											
KIAA0913	23053	broad.mit.edu	37	chr10	75553701	75553701	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaggcggccttcctgttgAcagtgctaagtgagcgtcca	8	9	13	11	2	0	2	0	2	0	0	2	2	2	2	3	2	2	3	3	2	2	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr10:75553701A>C	uc009xrl.2	+	12	2556	c.2524A>C	c.(2524-2526)ACA>CCA	p.T842P	KIAA0913_uc001jve.2_Missense_Mutation_p.T842P|KIAA0913_uc001jvf.2_Missense_Mutation_p.T842P|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.T265P|KIAA0913_uc010qkr.1_Missense_Mutation_p.T265P|KIAA0913_uc001jvj.2_Missense_Mutation_p.T265P	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	842							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					CTTCCTGTTGACAGTGCTAAG	0.562													7	20					0	0	0	0	C	75553701	C	C	75553701	3	2	231	1	0	0	0	0	1	0	0	0	8239	275	10	5	2570	5	KIAA0913	10	75553701	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	933512	75553701	59981046	96	42003											
NRG3	10718	broad.mit.edu	37	chr10	84625186	84625186	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagaccacttggggattgaAttcatgggtaagactaaaca	14	9	11	7	0	1	3	1	1	0	2	1	4	1	4	1	3	1	2	1	3	4	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr10:84625186A>T	uc001kco.2	+	4	1074	c.1047A>T	c.(1045-1047)GAA>GAT	p.E349D	NRG3_uc010qlz.1_Missense_Mutation_p.E348D|NRG3_uc001kcp.2_Missense_Mutation_p.E128D|NRG3_uc001kcq.2_5'UTR|NRG3_uc001kcr.2_5'UTR	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	349	Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TGGGGATTGAATTCATGGGTA	0.373													12	50					0	0	0	0	T	84625186	T	T	84625186	3	4	231	1	0	0	0	0	1	0	0	0	10703	98	4	5	1229	5	NRG3	10	84625186	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	9071485	84625186	50909561	97	42004											
CDHR1	92211	broad.mit.edu	37	chr10	85972970	85972970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggctcaagaattccatcCgctccctggatgccctgcac	7	10	8	16	1	2	1	1	0	1	1	5	2	5	2	4	2	2	3	4	2	2	1	rs148280890	byFrequency	TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr10:85972970C>T	uc001kcv.2	+	16	1906	c.1906C>T	c.(1906-1908)CGC>TGC	p.R636C	CDHR1_uc001kcw.2_Missense_Mutation_p.R636C|CDHR1_uc009xst.2_Missense_Mutation_p.R340C|CDHR1_uc001kcx.2_5'UTR	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	636	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						GAATTCCATCCGCTCCCTGGA	0.587													25	74					0	0	0	0	T	85972970	T	T	85972970	3	4	231	1	0	0	0	0	1	0	0	0	3133	652	23	1	1968	1	CDHR1	10	85972970	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	1347784	85972970	49561777	98	42005											
DMBT1	1755	broad.mit.edu	37	chr10	124402660	124402660	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgagggatgacacctacGgaccctactcctcgccatct	8	8	10	15	3	1	2	0	2	1	0	3	4	2	4	4	2	2	0	4	2	2	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr10:124402660G>A	uc001lgk.1	+	53	7094	c.6988G>A	c.(6988-6990)GGA>AGA	p.G2330R	DMBT1_uc001lgl.1_Missense_Mutation_p.G2320R|DMBT1_uc001lgm.1_Missense_Mutation_p.G1702R|DMBT1_uc009xzz.1_Missense_Mutation_p.G2329R|DMBT1_uc010qtx.1_Missense_Mutation_p.G1050R|DMBT1_uc009yab.1_Missense_Mutation_p.G1033R|DMBT1_uc009yac.1_Missense_Mutation_p.G624R	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2330	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGACACCTACGGACCCTACTC	0.552													16	89					0	0	0	0	A	124402660	A	A	124402660	3	1	231	1	0	0	0	0	1	0	0	0	4599	1117	39	1	7198	1	DMBT1	10	124402660	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	38429690	124402660	11132087	99	42006											
ELP4	26610	broad.mit.edu	37	chr11	31616423	31616423	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taagatgaaaatagcttggcGttaccagttattacccaaga	15	11	8	7	1	0	3	0	1	0	2	0	3	0	3	2	1	3	3	2	1	8	6			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr11:31616423G>A	uc001mtb.2	+	4	523	c.488G>A	c.(487-489)CGT>CAT	p.R163H	ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Missense_Mutation_p.R163H|ELP4_uc010rdz.1_Missense_Mutation_p.R163H	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	163					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					ATAGCTTGGCGTTACCAGTTA	0.318													6	22					0	0	0	0	A	31616423	A	A	31616423	3	1	231	1	0	0	0	0	1	0	0	0	5106	1145	40	1	502	1	ELP4	11	31616423	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08		31616423	103390093	100	42007											
SPRYD5	84767	broad.mit.edu	37	chr11	55653123	55653123	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacatttgtttgaagaacatGgctttcattgccagaaaagc	13	12	9	7	0	1	3	1	1	0	2	1	4	1	3	1	1	3	2	1	1	4	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr11:55653123G>A	uc010rip.1	+	2	311	c.219G>A	c.(217-219)ATG>ATA	p.M73I	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	73						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TGAAGAACATGGCTTTCATTG	0.478													11	13					0	0	0	0	A	55653123	A	A	55653123	3	1	231	1	0	0	0	0	1	0	0	0	15177	1348	47	4	221	4	SPRYD5	11	55653123	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	24036700	55653123	79353393	101	42008											
OR5T2	219464	broad.mit.edu	37	chr11	55999656	55999656	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttttcattgagtcttttaCatctttgttcctcaaactgt	7	22	4	8	0	4	1	2	1	2	0	5	1	5	1	1	0	2	1	1	0	2	8			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr11:55999656C>A	uc010rjc.1	-	1	1006	c.1006G>T	c.(1006-1008)GTA>TTA	p.V336L		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	336	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAGTCTTTTACATCTTTGTTC	0.328													17	49					1.5739e-10	2.30838e-10	1	0	A	55999656	A	A	55999656	3	1	231	1	0	0	0	0	1	0	0	0	11236	478	17	4	72	4	OR5T2	11	55999656	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	346533	55999656	79006860	102	42009											
NXF1	10482	broad.mit.edu	37	chr11	62564806	62564806	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaccttgcagggcggtaacGtcgtgggggcttcaacatca	8	9	13	11	3	2	0	2	0	0	0	3	0	2	0	1	4	4	3	1	4	3	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr11:62564806G>A	uc001nvf.1	-	12	1242	c.1106C>T	c.(1105-1107)ACG>ATG	p.T369M	NXF1_uc001nvg.1_3'UTR|NXF1_uc009yog.1_Missense_Mutation_p.T412M	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	369	Interaction with THOC4.|LRR 4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						GGGCGGTAACGTCGTGGGGGC	0.438													12	76					0	0	0	0	A	62564806	A	A	62564806	3	1	231	1	0	0	0	0	1	0	0	0	10836	1145	40	1	793	1	NXF1	11	62564806	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	6565150	62564806	72441710	103	42010											
MAP4K2	5871	broad.mit.edu	37	chr11	64563761	64563761	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgacctggggatgatgcgctGggtgaggcggttggtgggga	5	9	22	5	2	0	3	0	3	0	0	0	5	0	5	1	8	1	2	1	8	0	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr11:64563761G>T	uc001obh.2	-	24	1827	c.1735C>A	c.(1735-1737)CAG>AAG	p.Q579K	MAP4K2_uc001obg.2_RNA|MAP4K2_uc001obi.2_Missense_Mutation_p.Q571K	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	579	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						ATGATGCGCTGGGTGAGGCGG	0.413													18	44					9.16793e-09	1.29745e-08	1	0	T	64563761	T	T	64563761	3	4	231	1	0	0	0	0	1	0	0	0	9313	1357	47	4	763	4	MAP4K2	11	64563761	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	1998955	64563761	70442755	104	42011											
PACS1	55690	broad.mit.edu	37	chr11	65960978	65960978	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctattcagcttgaccctgaaGaaactcgtcatgctaaaaga	14	10	7	10	1	2	4	2	2	0	2	3	4	2	4	1	0	3	2	1	0	5	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr11:65960978G>C	uc001oha.1	+	2	512	c.378G>C	c.(376-378)AAG>AAC	p.K126N	PACS1_uc001ogz.1_Missense_Mutation_p.K126N	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	126					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						TGACCCTGAAGAAACTCGTCA	0.458													7	27					0	0	0	0	C	65960978	C	C	65960978	3	2	231	1	0	0	0	0	1	0	0	0	11426	933	33	2	384	2	PACS1	11	65960978	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	1397217	65960978	69045538	105	42012											
SHANK2	22941	broad.mit.edu	37	chr11	70333123	70333123	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcctcctggcttccagcCgcttctcacggtcgcggacg	4	10	11	16	5	1	0	1	0	1	0	6	1	4	1	4	3	1	3	4	3	0	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr11:70333123C>T	uc001oqc.2	-	21	3353	c.3275G>A	c.(3274-3276)CGG>CAG	p.R1092Q	SHANK2_uc010rqn.1_Missense_Mutation_p.R504Q|SHANK2_uc001opz.2_Missense_Mutation_p.R497Q|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	713					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGCTTCCAGCCGCTTCTCACG	0.721													13	347					0	0	0	0	T	70333123	T	T	70333123	3	4	231	1	0	0	0	0	1	0	0	0	14330	652	23	1	2282	1	SHANK2	11	70333123	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	4372145	70333123	64673393	106	42013											
MMP1	4312	broad.mit.edu	37	chr11	102666294	102666294	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtagaatgggagagtccaaGagaatggccgagttcatgag	14	7	15	5	1	1	4	1	1	0	3	2	7	2	4	2	2	0	2	2	2	4	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr11:102666294G>C	uc001phi.2	-	5	813	c.670C>G	c.(670-672)CTT>GTT	p.L224V	uc001phh.1_Intron|MMP1_uc010ruv.1_Missense_Mutation_p.L158V	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	224	Metalloprotease.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		GAGAGTCCAAGAGAATGGCCG	0.423													26	338					0	0	0	0	C	102666294	C	C	102666294	3	2	231	1	0	0	0	0	1	0	0	0	9701	942	33	2	763	2	MMP1	11	102666294	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	32333171	102666294	32340222	107	42014											
BCL9L	283149	broad.mit.edu	37	chr11	118773004	118773004	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggcacttcatgctccagcGgggggccccctaggctctgt	5	8	13	15	1	2	0	1	0	1	0	3	0	3	0	3	5	2	3	3	5	1	2	rs147951163	byFrequency	TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr11:118773004G>A	uc001pug.2	-	6	2413	c.1448C>T	c.(1447-1449)CCG>CTG	p.P483L	BCL9L_uc009zal.2_Missense_Mutation_p.P478L	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	483	Pro-rich.|Necessary for interaction with CTNNB1 (By similarity).				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		ATGCTCCAGCGGGGGGCCCCC	0.642													84	81					0	0	0	0	A	118773004	A	A	118773004	3	1	231	1	0	0	0	0	1	0	0	0	1384	1116	39	1	3063	1	BCL9L	11	118773004	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	16106710	118773004	16233512	108	42015											
CCDC15	80071	broad.mit.edu	37	chr11	124908334	124908334	+	Frame_Shift_Del	DEL	A	-	-																															attttattttcagaattaagAaaaagagagagcaagaatgt																										TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr11:124908334delA	uc001qbm.3	+	14	2678	c.2419delA	c.(2419-2421)AAAfs	p.K807fs		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	807	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CAGAATTAAGAAAAAGAGAGA	0.313													---	---	---								-	124908334	-	-	124908334	7	5	231	1	0	1	0	1	0	0	0	0	2796	247	9	0	2469	0	CCDC15	11	124908334	Frame_Shift_Del	DEL	A	TCGA-CV-7235-01A-11D-2012-08	6135330	124908334	10098182	109	42016											
CLEC4E	26253	broad.mit.edu	37	chr12	8693386	8693386	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtttcagatgatttagatGaattcattttttctctctct	8	21	6	6	0	4	4	2	2	2	2	6	4	4	4	0	0	0	1	0	0	2	7			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:8693386G>T	uc001quo.1	-	1	173	c.8C>A	c.(7-9)TCA>TAA	p.S3*		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	3	Cytoplasmic (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					TGATTTAGATGAATTCATTTT	0.269													12	43					0.00185496	0.00249389	1	0	T	8693386	T	T	8693386	4	4	231	1	0	0	0	0	0	1	0	0	3530	1294	45	2	675	2	CLEC4E	12	8693386	Nonsense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08		8693386	125158509	110	42017											
PRB2	653247	broad.mit.edu	37	chr12	11546907	11546907	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggggtgctccttgtggAtttcctggagaacaaagaga	9	11	15	6	0	0	2	0	0	0	2	2	5	2	3	2	4	2	1	2	4	2	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:11546907A>C	uc010shk.1	-	3	140	c.105T>G	c.(103-105)AAT>AAG	p.N35K		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTCCTTGTGGATTTCCTGGAG	0.488													46	97					0	0	0	0	C	11546907	C	C	11546907	3	2	231	1	0	0	0	0	1	0	0	0	12505	330	12	5	1149	5	PRB2	12	11546907	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	2853521	11546907	122304988	111	42018											
MANSC1	54682	broad.mit.edu	37	chr12	12483163	12483163	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cactgccctgggaggaactgCctggactggcctccctacct	6	8	11	16	0	0	0	0	0	0	0	1	3	1	3	5	4	4	0	5	4	2	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:12483163C>A	uc001rai.1	-	4	1352	c.1094G>T	c.(1093-1095)GGC>GTC	p.G365V	MANSC1_uc010shm.1_Missense_Mutation_p.G299V|MANSC1_uc001raj.1_Missense_Mutation_p.G331V|MANSC1_uc009zht.1_Missense_Mutation_p.G284V	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	365	Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		GGAGGAACTGCCTGGACTGGC	0.488													18	48					1.99824e-07	2.77916e-07	1	0	A	12483163	A	A	12483163	3	1	231	1	0	0	0	0	1	0	0	0	9277	739	26	4	205	4	MANSC1	12	12483163	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	936256	12483163	121368732	112	42019											
GSG1	83445	broad.mit.edu	37	chr12	13243618	13243618	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gccagacctttctcgcacagGggcttgggcaccttctgtgt	5	11	12	13	1	2	1	0	0	2	1	3	1	2	1	3	3	0	3	3	3	0	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:13243618G>A	uc001rbn.2	-	2	356	c.183C>T	c.(181-183)CCC>CCT	p.P61P	GSG1_uc001rbj.2_Silent_p.P48P|GSG1_uc001rbk.2_Silent_p.P48P|GSG1_uc001rbl.2_Silent_p.P48P|GSG1_uc001rbm.2_Silent_p.P48P|GSG1_uc001rbo.2_Silent_p.P61P|GSG1_uc001rbp.2_Silent_p.P61P|GSG1_uc001rbq.1_Silent_p.P61P	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	48						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		TCTCGCACAGGGGCTTGGGCA	0.542													25	69					0	0	0	0	A	13243618	A	A	13243618	2	1	231	1	0	0	0	0	0	0	0	1	6859	1219	43	4		4	GSG1	12	13243618	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	760455	13243618	120608277	113	42020											
PFKM	5213	broad.mit.edu	37	chr12	48526750	48526750	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagcgtgggatcaccaatCtctgtgtcattgggggtgat	8	12	14	7	1	3	2	2	2	1	0	4	3	3	3	1	3	1	0	1	3	2	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:48526750C>A	uc001rrc.2	+	5	507	c.337C>A	c.(337-339)CTC>ATC	p.L113I	PFKM_uc001rra.1_5'UTR|PFKM_uc001rrb.1_Missense_Mutation_p.L184I|PFKM_uc001rrd.2_5'UTR|PFKM_uc001rre.1_Missense_Mutation_p.L113I|PFKM_uc001rrg.1_Missense_Mutation_p.L113I	NM_000289	NP_000280	P08237	K6PF_HUMAN	phosphofructokinase, muscle	113					fructose 6-phosphate metabolic process|glycolysis|muscle cell homeostasis	6-phosphofructokinase complex|apical plasma membrane	6-phosphofructokinase activity|ATP binding|identical protein binding|kinase binding|metal ion binding|protein C-terminus binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4						GATCACCAATCTCTGTGTCAT	0.567													14	60					0.00244969	0.00327528	1	0	A	48526750	A	A	48526750	3	1	231	1	0	0	0	0	1	0	0	0	11820	913	32	2	572	2	PFKM	12	48526750	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	35283132	48526750	85325145	114	42021											
HSD17B6	8630	broad.mit.edu	37	chr12	57167654	57167654	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actatgtggctctacctggcGgccttcgtgggcctgtacta	5	12	12	12	2	1	0	0	0	1	0	2	0	1	0	3	4	2	2	3	4	4	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:57167654G>A	uc001smg.1	+	2	128	c.18G>A	c.(16-18)GCG>GCA	p.A6A		NM_003725	NP_003716	O14756	H17B6_HUMAN	hydroxysteroid (17-beta) dehydrogenase 6	6					androgen biosynthetic process|androgen catabolic process	early endosome membrane|endoplasmic reticulum|microsome	binding|electron carrier activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			upper_aerodigestive_tract(1)|pancreas(1)	2					Succinic acid(DB00139)	TCTACCTGGCGGCCTTCGTGG	0.438													14	65					0	0	0	0	A	57167654	A	A	57167654	2	1	231	1	0	0	0	0	0	0	0	1	7426	1103	39	1		1	HSD17B6	12	57167654	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	8640904	57167654	76684241	115	42022											
LRP1	4035	broad.mit.edu	37	chr12	57560805	57560805	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgacgactgtggggacCgctctgatgagtctgcttcg	6	11	15	9	3	2	3	0	3	2	0	3	6	2	5	1	3	1	2	1	3	0	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:57560805C>G	uc001snd.2	+	18	3356	c.2890C>G	c.(2890-2892)CGC>GGC	p.R964G	LRP1_uc009zph.1_5'Flank|LRP1_uc009zpi.1_5'Flank	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	964	LDL-receptor class A 5.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTGTGGGGACCGCTCTGATGA	0.657													20	87					0	0	0	0	G	57560805	G	G	57560805	3	3	231	1	0	0	0	0	1	0	0	0	9001	652	23	3	2960	3	LRP1	12	57560805	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	393151	57560805	76291090	116	42023											
WIF1	11197	broad.mit.edu	37	chr12	65461539	65461539	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcgtctttcattacaaaaGcctccatttcggcacccgcc	9	11	6	15	3	2	0	1	0	1	0	4	0	3	0	4	1	3	1	4	1	3	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:65461539G>C	uc001ssk.2	-	5	715	c.570C>G	c.(568-570)GGC>GGG	p.G190G		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	190	EGF-like 1.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		CATTACAAAAGCCTCCATTTC	0.507			T	HMGA2	pleomorphic salivary gland adenoma								9	26					0	0	0	0	C	65461539	C	C	65461539	2	2	231	1	0	0	0	0	0	0	0	1	17434	958	34	4		4	WIF1	12	65461539	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	7900734	65461539	68390356	117	42024											
GNPTAB	79158	broad.mit.edu	37	chr12	102159938	102159938	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttggtcacagaacttatcagCgagccaggaattcgcacatc	12	9	9	11	2	2	1	2	0	0	1	4	3	2	2	1	2	3	1	1	2	3	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:102159938C>G	uc001tit.2	-	12	1722	c.1543G>C	c.(1543-1545)GCT>CCT	p.A515P		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	515	LNR 2.				cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						AACTTATCAGCGAGCCAGGAA	0.483													31	114					0	0	0	0	G	102159938	G	G	102159938	3	3	231	1	0	0	0	0	1	0	0	0	6582	768	27	3	2267	3	GNPTAB	12	102159938	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	36698399	102159938	31691957	118	42025											
STAB2	55576	broad.mit.edu	37	chr12	104063402	104063402	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatccatgctcaggaaatggAcaggtgaatactgaagactg	15	8	11	7	0	1	3	1	2	0	1	2	5	2	5	1	3	2	1	1	3	5	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:104063402A>G	uc001tjw.2	+	21	2442	c.2256A>G	c.(2254-2256)GGA>GGG	p.G752G		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	752	Extracellular (Potential).|EGF-like 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CAGGAAATGGACAGGTGAATA	0.413													13	67					0	0	0	0	G	104063402	G	G	104063402	2	3	231	1	0	0	0	0	0	0	0	1	15304	262	10	5		5	STAB2	12	104063402	Silent	SNP	A	TCGA-CV-7235-01A-11D-2012-08	1903464	104063402	29788493	119	42026											
SVOP	55530	broad.mit.edu	37	chr12	109328032	109328032	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaactaacccgtagtaagaGaatgcattggaaaacctgcc	16	7	9	9	1	0	2	0	0	0	2	0	4	0	3	3	1	5	3	3	1	7	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:109328032G>C	uc010sxh.1	-	10	1159	c.987C>G	c.(985-987)TTC>TTG	p.F329L		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	329	Helical; (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						CGTAGTAAGAGAATGCATTGG	0.493													4	10					0	0	0	0	C	109328032	C	C	109328032	3	2	231	1	0	0	0	0	1	0	0	0	15489	933	33	2	683	2	SVOP	12	109328032	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	5264630	109328032	24523863	120	42027											
GPR109B	8843	broad.mit.edu	37	chr12	123200718	123200718	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggaggaacatagcttcGtgccaccggaaggtatggca	11	7	13	10	2	0	0	0	0	0	0	2	3	1	3	3	5	3	3	3	5	4	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:123200718G>A	uc001ucy.3	-	1	722	c.567C>T	c.(565-567)CAC>CAT	p.H189H	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	189	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	ACATAGCTTCGTGCCACCGGA	0.537													17	66					0	0	0	0	A	123200718	A	A	123200718	2	1	231	1	0	0	0	0	0	0	0	1	6664	1136	40	1		1	GPR109B	12	123200718	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	13872686	123200718	10651177	121	42028											
PUS1	80324	broad.mit.edu	37	chr12	132425944	132425944	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcacaaggaccgggacgttCaggatgagacctaccgcctg	10	5	13	13	4	1	1	1	1	0	1	1	5	1	4	4	3	1	2	4	3	2	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr12:132425944C>G	uc001ujf.2	+	5	1131	c.652C>G	c.(652-654)CAG>GAG	p.Q218E	PUS1_uc001ujg.2_Missense_Mutation_p.Q190E|PUS1_uc001ujh.2_Missense_Mutation_p.Q190E|PUS1_uc001uji.2_Missense_Mutation_p.Q165E	NM_025215	NP_079491	Q9Y606	TRUA_HUMAN	pseudouridine synthase 1 isoform 1	218						mitochondrion	pseudouridine synthase activity|pseudouridylate synthase activity|RNA binding			breast(1)|central_nervous_system(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.05e-08)|Epithelial(86;2.51e-07)|all cancers(50;2.94e-07)		CCGGGACGTTCAGGATGAGAC	0.592													8	48					0	0	0	0	G	132425944	G	G	132425944	3	3	231	1	0	0	0	0	1	0	0	0	12895	827	29	2	670	2	PUS1	12	132425944	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	9225226	132425944	1425951	122	42029											
LIG4	3981	broad.mit.edu	37	chr13	108862659	108862659	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagatttgtatatctgcttTgaatgcattatgaatgaatg	13	16	8	4	0	1	4	0	3	1	1	1	4	1	4	0	0	2	3	0	0	6	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr13:108862659T>G	uc001vqn.2	-	2	1231	c.958A>C	c.(958-960)AAA>CAA	p.K320Q	LIG4_uc001vqo.2_Missense_Mutation_p.K320Q|LIG4_uc010agg.1_Missense_Mutation_p.K253Q|LIG4_uc010agf.2_Missense_Mutation_p.K320Q|LIG4_uc001vqp.2_Missense_Mutation_p.K320Q	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	320					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					ATATCTGCTTTGAATGCATTA	0.338								NHEJ					35	30					0	0	0	0	G	108862659	G	G	108862659	3	3	231	1	0	0	0	0	1	0	0	0	8824	1821	63	5	1781	5	LIG4	13	108862659	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08		108862659	6307219	123	42030											
ARHGEF7	8874	broad.mit.edu	37	chr13	111953845	111953845	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagtcttgtggataccgtatAtgcattaaaggatgaagttc	12	13	11	5	1	1	1	0	1	1	0	2	4	1	3	1	2	2	3	1	2	6	6			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr13:111953845A>G	uc010tjo.1	+	19	2061	c.2009A>G	c.(2008-2010)TAT>TGT	p.Y670C	ARHGEF7_uc001vrv.3_Missense_Mutation_p.Y595C|ARHGEF7_uc001vrw.3_Missense_Mutation_p.Y595C|ARHGEF7_uc001vrx.3_Missense_Mutation_p.Y595C	NM_003899	NP_003890	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform a	Error:Variant_position_missing_in_Q14155_after_alignment					apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			GATACCGTATATGCATTAAAG	0.368													39	37					0	0	0	0	G	111953845	G	G	111953845	3	3	231	1	0	0	0	0	1	0	0	0	911	449	16	5	2619	5	ARHGEF7	13	111953845	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	3091186	111953845	3216033	124	42031											
LRP10	26020	broad.mit.edu	37	chr14	23346653	23346653	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcagtcctggccctggaaGatgaggacgatgtgctactg	9	8	14	10	1	0	2	0	1	0	1	1	5	1	4	2	3	3	2	2	3	2	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr14:23346653G>C	uc001whd.2	+	7	2612	c.2059G>C	c.(2059-2061)GAT>CAT	p.D687H	LRP10_uc001whe.2_Intron	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	687	Cytoplasmic (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		GGCCCTGGAAGATGAGGACGA	0.682													12	46					0	0	0	0	C	23346653	C	C	23346653	3	2	231	1	0	0	0	0	1	0	0	0	9002	942	33	2	2085	2	LRP10	14	23346653	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08		23346653	84002887	125	42032											
COCH	1690	broad.mit.edu	37	chr14	31346874	31346874	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccctcttgaggaattctCtgtgtatgggaacatagtat	9	14	10	8	0	2	1	0	1	2	0	3	3	2	3	1	2	2	2	1	2	5	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr14:31346874C>G	uc001wqr.2	+	4	259	c.179C>G	c.(178-180)TCT>TGT	p.S60C	COCH_uc001wqp.2_Missense_Mutation_p.S60C|COCH_uc001wqq.3_Missense_Mutation_p.S60C|uc001wqs.2_Intron|COCH_uc001wqt.1_5'Flank	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	60	LCCL.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		GAGGAATTCTCTGTGTATGGG	0.507													9	34					0	0	0	0	G	31346874	G	G	31346874	3	3	231	1	0	0	0	0	1	0	0	0	3671	913	32	2	189	2	COCH	14	31346874	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	8000221	31346874	76002666	126	42033											
AHNAK2	113146	broad.mit.edu	37	chr14	105415341	105415341	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcattttgaacttgctgtcTttggtagtcaggtccttgtt	5	18	11	7	0	2	1	1	1	1	0	3	1	3	1	1	3	2	4	1	3	2	7			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr14:105415341T>A	uc010axc.1	-	7	6567	c.6447A>T	c.(6445-6447)AAA>AAT	p.K2149N	AHNAK2_uc001ypx.2_Missense_Mutation_p.K2049N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2149						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACTTGCTGTCTTTGGTAGTCA	0.592													195	598					0	0	0	0	A	105415341	A	A	105415341	3	1	231	1	0	0	0	0	1	0	0	0	415	1606	56	5	10944	5	AHNAK2	14	105415341	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08	74068467	105415341	1934199	127	42034											
NIPA2	81614	broad.mit.edu	37	chr15	23006379	23006379	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttcgaaaagacacaggcaGacttgctagactaaagctga	15	9	9	8	1	0	4	0	1	0	3	1	5	0	4	0	1	2	3	0	1	5	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr15:23006379G>A	uc001yux.2	-	8	1538	c.925C>T	c.(925-927)CTG>TTG	p.L309L	NIPA2_uc001yuy.2_Silent_p.L309L|NIPA2_uc001yuz.2_Silent_p.L309L|NIPA2_uc001yva.2_Silent_p.L290L|NIPA2_uc001yvb.2_Silent_p.L309L|NIPA2_uc010ayb.2_Silent_p.L290L	NM_030922	NP_112184	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome	309	Cytoplasmic (Potential).					early endosome|integral to membrane|plasma membrane				haematopoietic_and_lymphoid_tissue(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		GACACAGGCAGACTTGCTAGA	0.373													20	30					0	0	0	0	A	23006379	A	A	23006379	2	1	231	1	0	0	0	0	0	0	0	1	10477	933	33	2		2	NIPA2	15	23006379	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08		23006379	79525013	128	42035											
SEMA6D	80031	broad.mit.edu	37	chr15	48060874	48060874	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagacctaaactgacaagctCtcggaaatttgtagttcaag	14	10	9	8	1	2	2	1	1	1	1	3	4	2	3	1	1	2	3	1	1	6	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr15:48060874C>G	uc010bek.2	+	18	2222	c.1862C>G	c.(1861-1863)TCT>TGT	p.S621C	SEMA6D_uc001zvw.2_Intron|SEMA6D_uc001zvy.2_Missense_Mutation_p.S621C|SEMA6D_uc001zvz.2_Intron|SEMA6D_uc001zwa.2_Intron|SEMA6D_uc001zwb.2_Intron|SEMA6D_uc001zwc.2_Intron	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	621	Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CTGACAAGCTCTCGGAAATTT	0.428													35	55					0	0	0	0	G	48060874	G	G	48060874	3	3	231	1	0	0	0	0	1	0	0	0	14107	913	32	2	1971	2	SEMA6D	15	48060874	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	25054495	48060874	54470518	129	42036											
LIPC	3990	broad.mit.edu	37	chr15	58840724	58840724	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccgccaggagccgcggagcaAgagcaagaggctcttcctcg	9	4	14	14	4	1	2	0	0	1	2	3	4	2	4	4	3	3	3	4	3	2	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr15:58840724A>G	uc010bga.1	+	8	1612	c.1004A>G	c.(1003-1005)AAG>AGG	p.K335R	LIPC_uc010bfz.1_Missense_Mutation_p.K335R|LIPC_uc002afa.1_Missense_Mutation_p.K335R|LIPC_uc010bgb.1_Missense_Mutation_p.K233R|LIPC_uc010ugy.1_Missense_Mutation_p.K274R	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	335					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		CCGCGGAGCAAGAGCAAGAGG	0.627													8	17					0	0	0	0	G	58840724	G	G	58840724	3	3	231	1	0	0	0	0	1	0	0	0	8862	72	3	5	1026	5	LIPC	15	58840724	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	10779850	58840724	43690668	130	42037											
CELF6	60677	broad.mit.edu	37	chr15	72608204	72608204	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acccctggcagggtcttctgCtcgtgcagtgcactctgggc	4	10	13	14	1	3	0	0	0	3	0	4	0	3	0	2	3	3	4	2	3	0	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	587d051a-9514-43de-a582-8cfd48c7355d	g.chr15:72608204C>T	uc002auh.2	-	2	637	c.327G>A	c.(325-327)GAG>GAA	p.E109E	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010ukm.1_Silent_p.E109E|CELF6_uc002aui.2_Missense_Mutation_p.A232T|CELF6_uc002auj.2_5'UTR	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	109	RRM 1.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						GGGTCTTCTGCTCGTGCAGTG	0.632													3	12					0	0	0	0	T	72608204	T	T	72608204	2	4	231	1	0	0	0	0	0	0	0	1	3235	796	28	4		4	CELF6	15	72608204	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	13767480	72608204	29923188	131	42038											
STOML1	9399	broad.mit.edu	37	chr15	74284510	74284510	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagccgaagctcgactgctGgaagcggtcaaaatcaccca	14	5	10	12	3	2	0	2	0	0	0	3	3	2	1	2	2	4	2	2	2	5	0			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr15:74284510G>A	uc002awe.2	-	1	126	c.55C>T	c.(55-57)CAG>TAG	p.Q19*	PML_uc002awm.2_5'Flank|PML_uc002awl.2_5'Flank|PML_uc002awj.1_5'Flank|PML_uc002awk.2_5'Flank|PML_uc002awn.2_5'Flank|PML_uc002awo.2_5'Flank|PML_uc002awp.2_5'Flank|PML_uc002awq.2_5'Flank|PML_uc002awr.2_5'Flank|PML_uc002aws.2_5'Flank|PML_uc002awt.2_5'Flank|PML_uc002awu.2_5'Flank|PML_uc002awv.2_5'Flank|PML_uc010ule.1_5'Flank|STOML1_uc002awf.2_Nonsense_Mutation_p.Q19*|STOML1_uc010bje.2_Nonsense_Mutation_p.Q19*|STOML1_uc010uld.1_5'UTR|STOML1_uc002awh.2_Nonsense_Mutation_p.Q19*|STOML1_uc002awg.2_Nonsense_Mutation_p.Q19*|STOML1_uc002awi.2_Intron	NM_004809	NP_004800	Q9UBI4	STML1_HUMAN	stomatin (EPB72)-like 1	19						integral to membrane	sterol binding			skin(1)	1						CTCGACTGCTGGAAGCGGTCA	0.716													7	55					0	0	0	0	A	74284510	A	A	74284510	4	1	231	1	0	0	0	0	0	1	0	0	15379	1357	47	4	1169	4	STOML1	15	74284510	Nonsense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	1676306	74284510	28246882	132	42039											
ADAMTS7	11173	broad.mit.edu	37	chr15	79059275	79059275	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccaggggccaccgacagAgtggcagagagcaggtgact	10	4	16	11	1	0	3	0	1	0	2	0	5	0	3	3	4	2	2	3	4	0	0			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr15:79059275A>G	uc002bej.3	-	19	3189	c.2978T>C	c.(2977-2979)CTC>CCC	p.L993P	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	993	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CCACCGACAGAGTGGCAGAGA	0.652													3	68					0	0	0	0	G	79059275	G	G	79059275	3	3	231	1	0	0	0	0	1	0	0	0	271	304	11	5	2106	5	ADAMTS7	15	79059275	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	4774765	79059275	23472117	133	42040											
PRR25	388199	broad.mit.edu	37	chr16	855768	855768	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcagtgtgcgaggtacagaCcgttccagggcctggcctgc	6	8	15	12	2	0	1	0	0	0	1	1	2	1	1	4	3	4	3	4	3	1	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr16:855768C>T	uc010uut.1	+	1	326	c.326C>T	c.(325-327)ACC>ATC	p.T109I		NM_001013638	NP_001013660	Q96S07	PRR25_HUMAN	proline rich 25	109										large_intestine(1)	1						GAGGTACAGACCGTTCCAGGG	0.667													6	20					0	0	0	0	T	855768	T	T	855768	3	4	231	1	0	0	0	0	1	0	0	0	12659	507	18	4	328	4	PRR25	16	855768	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08		855768	89498985	134	42041											
UBN1	29855	broad.mit.edu	37	chr16	4903155	4903155	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaaggtaaaaggccttcaGcctggagataaggtacaccc	13	6	13	9	0	1	1	1	0	0	1	1	3	1	2	3	5	2	2	3	5	5	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr16:4903155G>C	uc002cyb.2	+	2	576	c.237G>C	c.(235-237)CAG>CAC	p.Q79H	UBN1_uc010uxw.1_Missense_Mutation_p.Q79H|UBN1_uc002cyc.2_Missense_Mutation_p.Q79H	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	79	Sufficient for interaction with HIRA.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						AAGGCCTTCAGCCTGGAGATA	0.537													11	38					0	0	0	0	C	4903155	C	C	4903155	3	2	231	1	0	0	0	0	1	0	0	0	16960	962	34	4	239	4	UBN1	16	4903155	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	4047387	4903155	85451598	135	42042											
TP53	7157	broad.mit.edu	37	chr17	7577580	7577580	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aactgttacacatgtagttgTagtggatggtggtacagtca	11	13	12	5	0	1	0	1	0	0	0	1	1	1	1	0	3	3	5	0	3	5	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr17:7577580T>C	uc002gim.2	-	7	895	c.701A>G	c.(700-702)TAC>TGC	p.Y234C	TP53_uc002gig.1_Missense_Mutation_p.Y234C|TP53_uc002gih.2_Missense_Mutation_p.Y234C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y102C|TP53_uc010cng.1_Missense_Mutation_p.Y102C|TP53_uc002gii.1_Missense_Mutation_p.Y102C|TP53_uc010cnh.1_Missense_Mutation_p.Y234C|TP53_uc010cni.1_Missense_Mutation_p.Y234C|TP53_uc002gij.2_Missense_Mutation_p.Y234C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y141C|TP53_uc002gio.2_Missense_Mutation_p.Y102C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	234	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> F (in a sporadic cancer; somatic mutation).|Y -> K (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|Y -> N (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> Q (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y234C(70)|p.Y234H(13)|p.Y234N(11)|p.0?(7)|p.Y234S(6)|p.Y234*(4)|p.Y234D(3)|p.Y234del(3)|p.Y234fs*2(1)|p.V225fs*23(1)|p.Y234fs*6(1)|p.Y234fs*5(1)|p.Y234fs*4(1)|p.Y234R(1)|p.Y234Y(1)|p.H233_C242del10(1)|p.D228fs*12(1)|p.Y234F(1)|p.I232_Y236delIHYNY(1)|p.Y141S(1)|p.T230_Y234delTTIHY(1)|p.H233fs*6(1)|p.Y234_N235insX(1)|p.I232fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGTAGTTGTAGTGGATGGT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			45	25					0	0	0	0	C	7577580	C	C	7577580	3	2	231	1	0	0	0	0	1	0	0	0	16448	1638	57	5	589	5	TP53	17	7577580	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08		7577580	73617630	136	42043											
MYH8	4626	broad.mit.edu	37	chr17	10303758	10303758	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaggtcatcagtctccatCttcagctcactcttctcctt	6	15	5	15	0	8	1	4	1	4	0	10	1	8	1	2	1	1	1	2	1	0	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr17:10303758C>A	uc002gmm.2	-	27	3779	c.3684G>T	c.(3682-3684)AAG>AAT	p.K1228N	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1228	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CAGTCTCCATCTTCAGCTCAC	0.488									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				28	137					2.12542e-12	3.19472e-12	1	0	A	10303758	A	A	10303758	3	1	231	1	0	0	0	0	1	0	0	0	10094	912	32	2	2185	2	MYH8	17	10303758	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	2726178	10303758	70891452	137	42044											
HEXIM2	124790	broad.mit.edu	37	chr17	43246702	43246702	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggcctcccgggtccgcgaAgagatgttcgccaaaggcca	9	5	14	13	4	0	1	0	0	0	1	3	3	2	1	5	3	0	1	5	3	2	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr17:43246702A>G	uc002iih.1	+	4	626	c.387A>G	c.(385-387)GAA>GAG	p.E129E	HEXIM2_uc010daf.1_Silent_p.E151E|HEXIM2_uc002iii.1_Silent_p.E129E|HEXIM2_uc002iij.1_Silent_p.E129E|uc002iik.1_RNA	NM_144608	NP_653209	Q96MH2	HEXI2_HUMAN	hexamthylene bis-acetamide inducible 2	129					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding				0						GGGTCCGCGAAGAGATGTTCG	0.627													7	41					0	0	0	0	G	43246702	G	G	43246702	2	3	231	1	0	0	0	0	0	0	0	1	7116	69	3	5		5	HEXIM2	17	43246702	Silent	SNP	A	TCGA-CV-7235-01A-11D-2012-08	32942944	43246702	37948508	138	42045											
GH2	2689	broad.mit.edu	37	chr17	61958488	61958488	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaatgaatacttctgctcCttcaggatataggcttcttc	10	14	8	9	0	3	1	1	1	2	0	5	3	4	3	1	3	2	2	1	3	5	7			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr17:61958488C>T	uc002jco.1	-	3	254	c.192G>A	c.(190-192)AAG>AAA	p.K64K	GH2_uc002jcj.2_Silent_p.K64K|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_Silent_p.K64K|GH2_uc002jcm.1_Silent_p.K64K|GH2_uc002jcn.1_Intron	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	64						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						ACTTCTGCTCCTTCAGGATAT	0.507													106	79					0	0	0	0	T	61958488	T	T	61958488	2	4	231	1	0	0	0	0	0	0	0	1	6405	680	24	4		4	GH2	17	61958488	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08	18711786	61958488	19236722	139	42046											
CSNK1D	1453	broad.mit.edu	37	chr17	80211118	80211118	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaatgtattcgatgcgactGatctgtgagcagagcaaggg	11	10	14	6	2	1	4	0	3	1	1	2	6	1	4	0	1	3	3	0	1	3	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr17:80211118G>A	uc002kej.2	-	4	655	c.339C>T	c.(337-339)ATC>ATT	p.I113I	SLC16A3_uc002kee.2_Intron|CSNK1D_uc002kef.2_Silent_p.I113I|CSNK1D_uc002kei.2_Silent_p.I113I|CSNK1D_uc010wvj.1_Intron|CSNK1D_uc010dil.2_5'Flank|CSNK1D_uc002keh.2_5'UTR|CSNK1D_uc010dim.1_5'Flank	NM_001893	NP_001884	P48730	KC1D_HUMAN	casein kinase 1, delta isoform 1	113	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)	2	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			CGATGCGACTGATCTGTGAGC	0.552													55	40					0	0	0	0	A	80211118	A	A	80211118	2	1	231	1	0	0	0	0	0	0	0	1	3969	1280	45	2		2	CSNK1D	17	80211118	Silent	SNP	G	TCGA-CV-7235-01A-11D-2012-08	18252630	80211118	984092	140	42047											
DSC1	1823	broad.mit.edu	37	chr18	28713884	28713884	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacagaacccaacaccatagCaagaatagcccatcttccaa	17	6	4	14	0	1	2	0	0	1	2	2	2	2	2	4	0	5	1	4	0	8	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr18:28713884C>A	uc002kwn.2	-	13	2348	c.2086G>T	c.(2086-2088)GCT>TCT	p.A696S	DSC1_uc002kwm.2_Missense_Mutation_p.A696S	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	696	Helical; (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			AACACCATAGCAAGAATAGCC	0.318													24	23					3.10358e-05	4.21947e-05	1	0	A	28713884	A	A	28713884	3	1	231	1	0	0	0	0	1	0	0	0	4787	710	25	4	654	4	DSC1	18	28713884	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08		28713884	49363364	141	42048											
SETBP1	26040	broad.mit.edu	37	chr18	42530735	42530735	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatagagaatgagtccccctCagttggccttgaaactggtg	10	10	12	9	0	1	3	1	2	0	1	2	5	2	3	3	2	1	1	3	2	3	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr18:42530735C>A	uc010dni.2	+	4	1726	c.1430C>A	c.(1429-1431)TCA>TAA	p.S477*		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	477						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GAGTCCCCCTCAGTTGGCCTT	0.488									Schinzel-Giedion_syndrome				19	56					4.35082e-09	6.19352e-09	1	0	A	42530735	A	A	42530735	4	1	231	1	0	0	0	0	0	1	0	0	14194	838	29	2	1633	2	SETBP1	18	42530735	Nonsense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	13816851	42530735	35546513	142	42049											
DYM	54808	broad.mit.edu	37	chr18	46889584	46889584	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcacagcaattcttccaaAagatcttctgagtcagaacc	14	9	6	12	0	4	3	1	1	3	2	5	3	5	3	2	0	3	2	2	0	4	3			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr18:46889584A>T	uc002ldi.1	-	6	806	c.441T>A	c.(439-441)CTT>CTA	p.L147L	DYM_uc010xdf.1_Intron	NM_017653	NP_060123	Q7RTS9	DYM_HUMAN	dymeclin	147						Golgi apparatus					0						ATTCTTCCAAAAGATCTTCTG	0.348													6	27					0	0	0	0	T	46889584	T	T	46889584	2	4	231	1	0	0	0	0	0	0	0	1	4862	1	1	5		5	DYM	18	46889584	Silent	SNP	A	TCGA-CV-7235-01A-11D-2012-08	4358849	46889584	31187664	143	42050											
PNPLA6	10908	broad.mit.edu	37	chr19	7619913	7619913	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtgctcggggcacctgcaCctgcgctgtccgcgccgcct	2	8	14	17	5	0	0	0	0	0	0	2	0	1	0	5	3	3	4	5	3	0	0			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr19:7619913C>T	uc010xjq.1	+	24	2994	c.2799C>T	c.(2797-2799)CAC>CAT	p.H933H	PNPLA6_uc002mgq.1_Silent_p.H885H|PNPLA6_uc010xjp.1_Silent_p.H858H|PNPLA6_uc002mgr.1_Silent_p.H885H|PNPLA6_uc002mgs.2_Silent_p.H923H|PNPLA6_uc002mgt.1_RNA	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	924	Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						GGCACCTGCACCTGCGCTGTC	0.711													16	10					0	0	0	0	T	7619913	T	T	7619913	2	4	231	1	0	0	0	0	0	0	0	1	12224	506	18	4		4	PNPLA6	19	7619913	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08		7619913	51509070	144	42051											
PRDX2	7001	broad.mit.edu	37	chr19	12912075	12912075	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcgcgttaccggaggccaTgactgaaagctgagaccccc	9	5	13	14	4	0	3	0	3	0	1	0	5	0	4	4	2	2	2	4	2	2	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr19:12912075T>A	uc002mvd.2	-	2	151	c.1A>T	c.(1-3)ATG>TTG	p.M1L	PRDX2_uc002mve.1_Missense_Mutation_p.M1L	NM_005809	NP_005800	P32119	PRDX2_HUMAN	peroxiredoxin 2 isoform a	1					anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity				0						CCGGAGGCCATGACTGAAAGC	0.617													5	5					0	0	0	0	A	12912075	A	A	12912075	3	1	231	1	0	0	0	0	1	0	0	0	12527	1464	51	5	787	5	PRDX2	19	12912075	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08	5292162	12912075	46216908	145	42052											
CPAMD8	27151	broad.mit.edu	37	chr19	17088187	17088189	+	In_Frame_Del	DEL	GAA	-	-																															cgatgctctacctggttttcGaagaaggtctcgactgcaaa																										TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr19:17088187_17088189delGAA	uc002nfb.2	-	15	1920_1922	c.1888_1890delTTC	c.(1888-1890)TTCdel	p.F630del		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	583						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CCTGGTTTTCGAAGAAGGTCTCG	0.611													---	---	---								-	17088189	-	-	17088187	7	5	231	1	0	1	0	1	0	0	0	0	3810	1049	37	0	4020	0	CPAMD8	19	17088187	In_Frame_Del	DEL	GAA	TCGA-CV-7235-01A-11D-2012-08	4176112	17088187	42040796	146	42053											
CPAMD8	27151	broad.mit.edu	37	chr19	17122306	17122306	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcctcagatttggagagaCggtgaagatgcttatgagca	12	9	14	6	1	1	5	1	2	0	3	1	7	1	6	1	3	2	2	1	3	2	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr19:17122306C>T	uc002nfb.2	-	5	627	c.595G>A	c.(595-597)GTC>ATC	p.V199I		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	152						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TTTGGAGAGACGGTGAAGATG	0.587													20	65					0	0	0	0	T	17122306	T	T	17122306	3	4	231	1	0	0	0	0	1	0	0	0	3810	536	19	1	5355	1	CPAMD8	19	17122306	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	34119	17122306	42006677	147	42054											
ZNF181	339318	broad.mit.edu	37	chr19	35232698	35232698	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatatgtgggaaagcctttaGtcataggtcatccctgcttc	9	14	9	9	0	2	0	2	0	0	0	4	1	3	1	2	2	2	1	2	2	5	6			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr19:35232698G>T	uc002nvu.3	+	4	1875	c.1412G>T	c.(1411-1413)AGT>ATT	p.S471I	ZNF181_uc010xsa.1_Missense_Mutation_p.S470I|ZNF181_uc010xsb.1_Missense_Mutation_p.S470I|ZNF181_uc010xsc.1_Missense_Mutation_p.S406I	NM_001029997	NP_001025168	Q2M3W8	ZN181_HUMAN	zinc finger protein 181 isoform 1	471	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			AAAGCCTTTAGTCATAGGTCA	0.388													23	56					6.32553e-13	9.56737e-13	1	0	T	35232698	T	T	35232698	3	4	231	1	0	0	0	0	1	0	0	0	17816	1029	36	4	1426	4	ZNF181	19	35232698	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	18110392	35232698	23896285	148	42055											
PSG8	440533	broad.mit.edu	37	chr19	43259226	43259226	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtcctgtttcatttctcGtgacactgggtagaatgagg	8	13	13	7	1	2	3	1	2	1	1	4	3	3	3	1	3	0	2	1	3	2	3	rs150991804		TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr19:43259226G>C	uc002ouo.2	-	4	1000	c.902C>G	c.(901-903)ACG>AGG	p.T301R	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_Intron|PSG8_uc002oui.2_Missense_Mutation_p.T140R|PSG8_uc002ouh.2_Missense_Mutation_p.T301R|PSG8_uc010ein.2_Missense_Mutation_p.T179R|PSG8_uc002ouj.3_Missense_Mutation_p.T83R|PSG8_uc002ouk.3_Missense_Mutation_p.T140R|PSG8_uc002oul.3_Missense_Mutation_p.T301R|PSG8_uc002oum.3_Missense_Mutation_p.T208R|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.T208R	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	301	Ig-like C2-type 2.					extracellular region					0		Prostate(69;0.00899)				TTCATTTCTCGTGACACTGGG	0.478													92	77					0	0	0	0	C	43259226	C	C	43259226	3	2	231	1	0	0	0	0	1	0	0	0	12723	1145	40	3	407	3	PSG8	19	43259226	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	8026528	43259226	15869757	149	42056											
CALM3	808	broad.mit.edu	37	chr19	47111573	47111573	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgaagcagagctgcaggatAtgatcaatgaggtggatgca	13	8	14	6	0	1	4	1	3	0	1	1	6	1	6	0	3	4	4	0	3	3	1			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr19:47111573A>G	uc002pew.2	+	3	334	c.154A>G	c.(154-156)ATG>GTG	p.M52V	CALM3_uc010ekp.2_Missense_Mutation_p.M16V|CALM3_uc010xyc.1_Missense_Mutation_p.M52V	NM_005184	NP_005175	P62158	CALM_HUMAN	calmodulin 3	52	EF-hand 2.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			ovary(1)	1		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000683)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0341)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	GCTGCAGGATATGATCAATGA	0.582													28	20					0	0	0	0	G	47111573	G	G	47111573	3	3	231	1	0	0	0	0	1	0	0	0	2598	449	16	5	164	5	CALM3	19	47111573	Missense_Mutation	SNP	A	TCGA-CV-7235-01A-11D-2012-08	3852347	47111573	12017410	150	42057											
ZNF8	7554	broad.mit.edu	37	chr19	58806142	58806142	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaatgtgggaagtctttctGccatagtacacaccttaccg	10	11	9	11	2	2	0	0	0	2	0	2	2	2	1	3	1	3	1	3	1	5	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr19:58806142G>T	uc002qry.1	+	4	1098	c.968G>T	c.(967-969)TGC>TTC	p.C323F	ZNF8_uc002qrz.2_RNA	NM_021089	NP_066575	P17098	ZNF8_HUMAN	zinc finger protein 8	323	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		AAGTCTTTCTGCCATAGTACA	0.557													25	23					2.39556e-15	3.66916e-15	1	0	T	58806142	T	T	58806142	3	4	231	1	0	0	0	0	1	0	0	0	18234	1319	46	4	982	4	ZNF8	19	58806142	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	11694569	58806142	322841	151	42058											
PRNP	5621	broad.mit.edu	37	chr20	4680247	4680247	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtggggggccttggcggCtacatgctgggaagtgccat	5	9	19	8	1	0	0	0	0	0	0	0	1	0	1	2	7	3	2	2	7	2	2	rs11538754		TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr20:4680247C>A	uc002wku.2	+	2	744	c.381C>A	c.(379-381)GGC>GGA	p.G127G	PRNP_uc002wkv.2_Silent_p.G127G|PRNP_uc002wkw.2_Silent_p.G127G|PRNP_uc002wkx.2_Silent_p.G127G|PRNP_uc002wkt.1_Silent_p.G97G|PRNP_uc002wky.2_Silent_p.G127G|PRNP_uc010gbe.1_Silent_p.G127G	NM_001080122	NP_001073591	P04156	PRIO_HUMAN	prion protein preproprotein	127	Interaction with GRB2, ERI3 and SYN1 (By similarity).				axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(1)	1					Tetracycline(DB00759)	GCCTTGGCGGCTACATGCTGG	0.557													32	37					7.65355e-07	1.05838e-06	1	0	A	4680247	A	A	4680247	2	1	231	1	0	0	0	0	0	0	0	1	12606	784	28	4		4	PRNP	20	4680247	Silent	SNP	C	TCGA-CV-7235-01A-11D-2012-08		4680247	58345273	152	42059											
PCSK2	5126	broad.mit.edu	37	chr20	17462446	17462446	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgactccaaggtgggctttGacaagtggcctttcatgacc	9	10	11	11	1	1	2	1	2	0	0	2	3	2	2	3	3	0	1	3	3	2	2			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr20:17462446G>C	uc002wpm.2	+	12	1968	c.1648G>C	c.(1648-1650)GAC>CAC	p.D550H	PCSK2_uc002wpl.2_Missense_Mutation_p.D531H|PCSK2_uc010zrm.1_Missense_Mutation_p.D515H|PCSK2_uc002wpn.2_Missense_Mutation_p.D204H	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	550					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGTGGGCTTTGACAAGTGGCC	0.597													11	31					0	0	0	0	C	17462446	C	C	17462446	3	2	231	1	0	0	0	0	1	0	0	0	11655	1290	45	2	1694	2	PCSK2	20	17462446	Missense_Mutation	SNP	G	TCGA-CV-7235-01A-11D-2012-08	12782199	17462446	45563074	153	42060											
SON	6651	broad.mit.edu	37	chr21	34926744	34926744	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagcagatttagtgagacCgttacttcctaaggacatgg	12	11	11	7	1	0	3	0	2	0	2	1	5	1	4	2	2	2	2	2	2	4	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr21:34926744C>T	uc002yse.1	+	3	5256	c.5207C>T	c.(5206-5208)CCG>CTG	p.P1736L	SON_uc002ysb.1_Missense_Mutation_p.P1736L|SON_uc002ysc.2_Missense_Mutation_p.P1736L|SON_uc002ysd.2_Missense_Mutation_p.P727L|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.P727L	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1736					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TTAGTGAGACCGTTACTTCCT	0.453													21	77					0	0	0	0	T	34926744	T	T	34926744	3	4	231	1	0	0	0	0	1	0	0	0	14990	652	23	1	5217	1	SON	21	34926744	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08		34926744	13203151	154	42061											
SMTN	6525	broad.mit.edu	37	chr22	31485785	31485785	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccacagtgacactcctgcTgcgagccccacctgggagca	9	5	11	16	1	0	1	0	1	0	0	1	4	1	2	5	1	4	2	5	1	0	0			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr22:31485785T>C	uc003ajl.1	+	7	790	c.572T>C	c.(571-573)CTG>CCG	p.L191P	SMTN_uc003ajk.1_Missense_Mutation_p.L191P|SMTN_uc003ajm.1_Missense_Mutation_p.L191P|SMTN_uc011ale.1_Missense_Mutation_p.L245P|SMTN_uc011alf.1_Missense_Mutation_p.L247P|SMTN_uc003ajn.1_Missense_Mutation_p.L183P|SMTN_uc011alg.1_5'Flank	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	191					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						ACACTCCTGCTGCGAGCCCCA	0.637													14	51					0	0	0	0	C	31485785	C	C	31485785	3	2	231	1	0	0	0	0	1	0	0	0	14878	1580	55	5	594	5	SMTN	22	31485785	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08		31485785	19818781	155	42062											
CACNG2	10369	broad.mit.edu	37	chr22	37098605	37098605	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttaaaagcatttgaacacctCgatcaaacagccccataatt	16	10	4	11	1	1	1	1	1	0	0	2	2	1	1	3	0	4	1	3	0	5	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chr22:37098605C>G	uc003aps.1	-	1	299	c.17G>C	c.(16-18)CGA>CCA	p.R6P	uc003apt.1_5'Flank	NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	6					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						TTGAACACCTCGATCAAACAG	0.468													13	85					0	0	0	0	G	37098605	G	G	37098605	3	3	231	1	0	0	0	0	1	0	0	0	2569	884	31	3	970	3	CACNG2	22	37098605	Missense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08	5612820	37098605	14205961	156	42063											
FAM47A	158724	broad.mit.edu	37	chrX	34148619	34148619	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagagtcagaaacgcactCttttgtgcttggtgtatctt	10	14	10	7	1	3	2	1	0	2	2	3	3	3	2	0	1	2	3	0	1	3	5			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chrX:34148619C>A	uc004ddg.2	-	1	1810	c.1777G>T	c.(1777-1779)GAG>TAG	p.E593*		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	593										ovary(4)|central_nervous_system(1)	5						GAAACGCACTCTTTTGTGCTT	0.468													15	17					1.3612e-06	1.87165e-06	1	0	A	34148619	A	A	34148619	4	1	231	1	0	0	0	0	0	1	0	0	5601	922	32	2	602	2	FAM47A	23	34148619	Nonsense_Mutation	SNP	C	TCGA-CV-7235-01A-11D-2012-08		34148619	121121941	157	42064											
CXorf57	55086	broad.mit.edu	37	chrX	105868408	105868408	+	Frame_Shift_Del	DEL	T	-	-																															gtggtataaaagtttgcgggTtggtttagttcttctgcttc																										TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chrX:105868408delT	uc004emi.3	+	3	1026	c.875delT	c.(874-876)GTTfs	p.V292fs	CXorf57_uc004emj.3_Frame_Shift_Del_p.V292fs|CXorf57_uc004emh.2_Frame_Shift_Del_p.V292fs	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	292										ovary(1)|lung(1)|breast(1)	3						AGTTTGCGGGTTGGTTTAGTT	0.408													---	---	---								-	105868408	-	-	105868408	7	5	231	1	0	1	0	1	0	0	0	0	4130	1725	60	0	885	0	CXorf57	23	105868408	Frame_Shift_Del	DEL	T	TCGA-CV-7235-01A-11D-2012-08	71719789	105868408	49402152	158	42065											
NKRF	55922	broad.mit.edu	37	chrX	118723979	118723979	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaggcctgtcatcctttcaTagacatactcaactgtcatt	10	13	7	11	0	4	1	4	0	0	1	5	2	5	2	2	2	2	0	2	2	3	4			TCGA-CV-7235-01A-11D-2012-08	TCGA-CV-7235-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	1758147b-cb09-430b-a8cb-6a144744a79f	42d49395-457d-4661-a6ce-ec6f888b7570	g.chrX:118723979T>C	uc004erq.2	-	2	2062	c.1409A>G	c.(1408-1410)TAT>TGT	p.Y470C	NKRF_uc004err.2_Missense_Mutation_p.Y470C	NM_017544	NP_060014	O15226	NKRF_HUMAN	transcription factor NRF	470					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			ovary(1)|central_nervous_system(1)	2						CATCCTTTCATAGACATACTC	0.408													3	81					0	0	0	0	C	118723979	C	C	118723979	3	2	231	1	0	0	0	0	1	0	0	0	10501	1406	49	5	667	5	NKRF	23	118723979	Missense_Mutation	SNP	T	TCGA-CV-7235-01A-11D-2012-08	12855571	118723979	36546581	159	42066											
UBE2J2	118424	broad.mit.edu	37	chr1	1191442	1191443	+	Frame_Shift_Del	DEL	AT	-	-																															tacctccacgacttcaggaaAtaattcacaaaagactttat																										TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:1191442_1191443delAT	uc001adn.2	-	6	787_788	c.477_478delAT	c.(475-480)TTATTTfs	p.L159fs	UBE2J2_uc001adm.2_Frame_Shift_Del_p.L124fs|UBE2J2_uc001ado.2_Frame_Shift_Del_p.L175fs|UBE2J2_uc001adp.2_Frame_Shift_Del_p.L159fs|UBE2J2_uc001adq.2_Frame_Shift_Del_p.L107fs|UBE2J2_uc001adr.2_Frame_Shift_Del_p.L107fs|UBE2J2_uc001ads.2_Frame_Shift_Del_p.L107fs	NM_194458	NP_919440	Q8N2K1	UB2J2_HUMAN	ubiquitin conjugating enzyme E2, J2 isoform 3	159_160	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		ACTTCAGGAAATAATTCACAAA	0.401													---	---	---								-	1191443	-	-	1191442	7	5	232	1	0	1	0	1	0	0	0	0	16929	101	4	0	309	0	UBE2J2	1	1191442	Frame_Shift_Del	DEL	AT	TCGA-CV-7236-01A-11D-2012-08		1191442	248059179	1	42067											
IPO13	9670	broad.mit.edu	37	chr1	44433123	44433123	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctggtttcccctctgcccGcctcagccctgaacagaagg	7	8	9	17	1	2	2	1	1	1	1	3	2	3	2	6	2	3	1	6	2	2	1			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:44433123G>A	uc001ckx.2	+	19	3545	c.2750G>A	c.(2749-2751)CGC>CAC	p.R917H	IPO13_uc001cky.2_Missense_Mutation_p.R135H	NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	917					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CCCTCTGCCCGCCTCAGCCCT	0.617													8	55					0	0	0	0	A	44433123	A	A	44433123	3	1	232	1	0	0	0	0	1	0	0	0	7833	1087	38	1	2824	1	IPO13	1	44433123	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	43241681	44433123	204817498	2	42068											
ODF2L	57489	broad.mit.edu	37	chr1	86850380	86850382	+	In_Frame_Del	DEL	AAG	-	-																															tgtttgtagtctctctttctAagaagatgttctaaagctag																										TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:86850380_86850382delAAG	uc001dll.1	-	4	689_691	c.349_351delCTT	c.(349-351)CTTdel	p.L117del	ODF2L_uc001dlm.1_In_Frame_Del_p.L117del|ODF2L_uc001dln.2_In_Frame_Del_p.L117del|ODF2L_uc001dlo.2_5'UTR|ODF2L_uc001dlp.2_In_Frame_Del_p.L117del|ODF2L_uc010osg.1_In_Frame_Del_p.L117del|ODF2L_uc001dlq.1_Intron|ODF2L_uc009wcr.1_Intron	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	117						centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		CTCTCTTTCTAAGAAGATGTTCT	0.286													---	---	---								-	86850382	-	-	86850380	7	5	232	1	0	1	0	1	0	0	0	0	10882	349	13	0	1795	0	ODF2L	1	86850380	In_Frame_Del	DEL	AAG	TCGA-CV-7236-01A-11D-2012-08	42417257	86850380	162400241	3	42069											
HRNR	388697	broad.mit.edu	37	chr1	152188024	152188024	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctccatgttggccacagctCgatgactgtcctgatgcaga	8	10	11	12	1	0	3	0	2	0	1	3	4	2	3	3	1	2	4	3	1	0	1	rs142170860		TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:152188024C>T	uc001ezt.1	-	3	6157	c.6081G>A	c.(6079-6081)TCG>TCA	p.S2027S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2027	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCACAGCTCGATGACTGTC	0.562													56	618					0	0	0	0	T	152188024	T	T	152188024	2	4	232	1	0	0	0	0	0	0	0	1	7398	871	31	1		1	HRNR	1	152188024	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08	65337644	152188024	97062597	4	42070											
SPTA1	6708	broad.mit.edu	37	chr1	158621162	158621162	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggagccttagttacctgccGgatttgagctccttctggtg	5	13	13	10	1	1	1	0	1	1	0	2	3	2	3	4	3	4	2	4	3	2	4			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:158621162G>A	uc001fst.1	-	24	3671	c.3472C>T	c.(3472-3474)CGG>TGG	p.R1158W		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1158	Spectrin 11.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GTTACCTGCCGGATTTGAGCT	0.458													21	194					0	0	0	0	A	158621162	A	A	158621162	3	1	232	1	0	0	0	0	1	0	0	0	15182	1115	39	1	3903	1	SPTA1	1	158621162	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	6433138	158621162	90629459	5	42071											
USH2A	7399	broad.mit.edu	37	chr1	215847770	215847770	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggggtgagagtaaaatcacGatagcgtgtttccaagcctg	11	10	13	7	2	1	1	1	1	0	1	2	3	2	1	2	2	2	2	2	2	4	3			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr1:215847770G>A	uc001hku.1	-	63	13870	c.13483C>T	c.(13483-13485)CGT>TGT	p.R4495C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4495	Fibronectin type-III 30.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTAAAATCACGATAGCGTGTT	0.458										HNSCC(13;0.011)			28	165					0	0	0	0	A	215847770	A	A	215847770	3	1	232	1	0	0	0	0	1	0	0	0	17104	1058	37	1	2165	1	USH2A	1	215847770	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	57226608	215847770	33402851	6	42072											
FAM98A	25940	broad.mit.edu	37	chr2	33820638	33820638	+	Frame_Shift_Del	DEL	G	-	-																															gcacagagtttggtaaactcGggggaactggctccagcaga																										TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr2:33820638delG	uc002rpa.1	-	2	194	c.120delC	c.(118-120)CCCfs	p.P40fs	FAM98A_uc010yne.1_5'UTR	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	40										ovary(1)	1	all_hematologic(175;0.115)					TGGTAAACTCGGGGGAACTGG	0.448													---	---	---								-	33820638	-	-	33820638	7	5	232	1	0	1	0	1	0	0	0	0	5688	1103	39	0	1464	0	FAM98A	2	33820638	Frame_Shift_Del	DEL	G	TCGA-CV-7236-01A-11D-2012-08		33820638	209378735	7	42073											
BAZ2B	29994	broad.mit.edu	37	chr2	160206265	160206265	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaagccaacaggattctgaGcagaagatccaagaggagct	15	7	11	8	0	1	4	0	1	1	3	2	6	2	6	2	2	4	2	2	2	4	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr2:160206265G>A	uc002uao.2	-	28	5169	c.4817C>T	c.(4816-4818)GCT>GTT	p.A1606V	BAZ2B_uc002uap.2_Missense_Mutation_p.A1570V	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1606					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AGGATTCTGAGCAGAAGATCC	0.423													3	62					0	0	0	0	A	160206265	A	A	160206265	3	1	232	1	0	0	0	0	1	0	0	0	1334	971	34	4	1729	4	BAZ2B	2	160206265	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	126385627	160206265	82993108	8	42074											
EVX2	344191	broad.mit.edu	37	chr2	176947144	176947144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagcccgacgccgacgtcGtggtgccggcagccgagccg	5	4	16	16	8	0	1	0	1	0	0	1	4	0	1	5	2	4	1	5	2	0	0			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr2:176947144G>A	uc010zeu.1	-	2	647	c.461C>T	c.(460-462)ACG>ATG	p.T154M		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	154						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CGCCGACGTCGTGGTGCCGGC	0.711													4	30					0	0	0	0	A	176947144	A	A	176947144	3	1	232	1	0	0	0	0	1	0	0	0	5319	1145	40	1	975	1	EVX2	2	176947144	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	16740879	176947144	66252229	9	42075											
TTN	7273	broad.mit.edu	37	chr2	179411521	179411521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctacctcactgactggcttaCgctctatgatgtagcccaca	9	11	7	14	1	2	2	1	2	1	0	2	2	2	2	2	1	3	3	2	1	4	4			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr2:179411521C>T	uc010zfg.1	-	290	87154	c.86930G>A	c.(86929-86931)CGT>CAT	p.R28977H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R22672H|TTN_uc010zfi.1_Missense_Mutation_p.R22605H|TTN_uc010zfj.1_Missense_Mutation_p.R22480H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29904							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTGGCTTACGCTCTATGAT	0.498													12	59					0	0	0	0	T	179411521	T	T	179411521	3	4	232	1	0	0	0	0	1	0	0	0	16803	536	19	1	13433	1	TTN	2	179411521	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08	2464377	179411521	63787852	10	42076											
CHL1	10752	broad.mit.edu	37	chr3	369940	369940	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaacattcaggatcccaaaCgaggggcacatatctcactt	13	8	9	11	1	2	0	2	0	1	0	4	3	3	2	1	4	2	1	1	4	3	3			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr3:369940C>T	uc003bou.2	+	5	559	c.288C>T	c.(286-288)AAC>AAT	p.N96N	CHL1_uc003bot.2_Silent_p.N96N|CHL1_uc003bow.1_Silent_p.N96N|CHL1_uc011asi.1_Silent_p.N96N	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	96	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GGATCCCAAACGAGGGGCACA	0.388													14	80					0	0	0	0	T	369940	T	T	369940	2	4	232	1	0	0	0	0	0	0	0	1	3364	535	19	1		1	CHL1	3	369940	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08		369940	197652490	11	42077											
FGD5	152273	broad.mit.edu	37	chr3	14942543	14942543	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctccaaagtcacagaccGtgccaacgacagcatggagc	13	5	9	14	2	2	1	1	0	1	1	3	3	2	2	3	1	4	1	3	1	2	0			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr3:14942543G>A	uc003bzc.2	+	9	3349	c.3239G>A	c.(3238-3240)CGT>CAT	p.R1080H	FGD5_uc011avk.1_Missense_Mutation_p.R1080H|FGD5_uc003bzd.2_Missense_Mutation_p.R158H	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1080	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						GTCACAGACCGTGCCAACGAC	0.607													22	101					0	0	0	0	A	14942543	A	A	14942543	3	1	232	1	0	0	0	0	1	0	0	0	5868	1145	40	1	3273	1	FGD5	3	14942543	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	14572603	14942543	183079887	12	42078											
WDR49	151790	broad.mit.edu	37	chr3	167240197	167240197	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaaataaagaaatttcctTttgaatctcactttccacta	16	14	3	8	0	1	3	1	1	1	2	4	3	3	3	2	0	0	0	2	0	7	6			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr3:167240197T>A	uc003fev.1	-	12	1930	c.1624A>T	c.(1624-1626)AAG>TAG	p.K542*	WDR49_uc003feu.1_Nonsense_Mutation_p.K367*|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	542										large_intestine(1)|ovary(1)|skin(1)	3						GAAATTTCCTTTTGAATCTCA	0.318													21	40					0	0	0	0	A	167240197	A	A	167240197	4	1	232	1	0	0	0	0	0	1	0	0	17370	1850	64	5	485	5	WDR49	3	167240197	Nonsense_Mutation	SNP	T	TCGA-CV-7236-01A-11D-2012-08	152297654	167240197	30782233	13	42079											
ENPEP	2028	broad.mit.edu	37	chr4	111398075	111398075	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtacaaaaagcaggagtacGtggtggtcgaggcggaggaa	14	5	17	5	3	0	0	0	0	0	0	1	4	0	3	0	6	3	3	0	6	5	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr4:111398075G>A	uc003iab.3	+	1	847	c.505G>A	c.(505-507)GTG>ATG	p.V169M		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	169	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GCAGGAGTACGTGGTGGTCGA	0.632													31	165					0	0	0	0	A	111398075	A	A	111398075	3	1	232	1	0	0	0	0	1	0	0	0	5152	1145	40	1	507	1	ENPEP	4	111398075	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08		111398075	79756201	14	42080											
RAPGEF2	9693	broad.mit.edu	37	chr4	160251524	160251524	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaatgcatttggtggaagaGcattcagtagtagatccaac	14	10	10	7	0	1	2	1	0	0	2	2	3	2	3	1	2	3	4	1	2	5	4			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr4:160251524G>A	uc003iqg.3	+	7	1168	c.858G>A	c.(856-858)GAG>GAA	p.E286E		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	286	N-terminal Ras-GEF.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TGGTGGAAGAGCATTCAGTAG	0.313													17	88					0	0	0	0	A	160251524	A	A	160251524	2	1	232	1	0	0	0	0	0	0	0	1	13109	962	34	4		4	RAPGEF2	4	160251524	Silent	SNP	G	TCGA-CV-7236-01A-11D-2012-08	48853449	160251524	30902752	15	42081											
HAND2	9464	broad.mit.edu	37	chr4	174449919	174449919	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttctcctctttcacgtcGgtcttcttgatctctgcctt	2	19	5	15	2	7	1	1	1	6	0	10	1	7	1	2	1	1	0	2	1	0	5			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr4:174449919G>A	uc003ith.1	-	1	1460	c.522C>T	c.(520-522)ACC>ACT	p.T174T	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Nonsense_Mutation_p.R140*|HAND2_uc010ire.1_Silent_p.T174T	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	174					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CTTTCACGTCGGTCTTCTTGA	0.627													14	34					0	0	0	0	A	174449919	A	A	174449919	2	1	232	1	0	0	0	0	0	0	0	1	6989	1103	39	1		1	HAND2	4	174449919	Silent	SNP	G	TCGA-CV-7236-01A-11D-2012-08	14198395	174449919	16704357	16	42082											
HIST1H2BK	85236	broad.mit.edu	37	chr6	27114571	27114571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggagcggacttcgctggttCcggcatgttgaaggcgaact	7	9	16	9	4	0	1	0	1	0	0	2	4	1	3	1	5	2	4	1	5	2	3			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr6:27114571C>T	uc003nix.1	-	1	49	c.7G>A	c.(7-9)GAA>AAA	p.E3K	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	3					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						TTCGCTGGTTCCGGCATGTTG	0.567													8	84					0	0	0	0	T	27114571	T	T	27114571	3	4	232	1	0	0	0	0	1	0	0	0	7189	864	30	2	377	2	HIST1H2BK	6	27114571	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08		27114571	144000496	17	42083											
EPDR1	54749	broad.mit.edu	37	chr7	37988614	37988614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctcaggagcagatcaccGtccaggagtggtcggacaga	10	5	15	11	2	2	2	2	0	0	2	4	5	3	5	3	5	1	1	3	5	0	0			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr7:37988614G>A	uc003tfp.2	+	2	821	c.802G>A	c.(802-804)GTC>ATC	p.V268I	EPDR1_uc003tfq.2_Intron|EPDR1_uc010kxh.2_Missense_Mutation_p.V87I	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	148					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						GCAGATCACCGTCCAGGAGTG	0.493													7	85					0	0	0	0	A	37988614	A	A	37988614	3	1	232	1	0	0	0	0	1	0	0	0	5187	1145	40	1	808	1	EPDR1	7	37988614	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08		37988614	121150049	18	42084											
EGFR	1956	broad.mit.edu	37	chr7	55221819	55221831	+	Frame_Shift_Del	DEL	GTGCCACCTGCGT	-	-																															cgagggcaaatacagctttgGtgccacctgcgtgaagaagt																								rs149840192		TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr7:55221819_55221831delGTGCCACCTGCGT	uc003tqk.2	+	7	1109_1121	c.863_875delGTGCCACCTGCGT	c.(862-876)GGTGCCACCTGCGTGfs	p.G288fs	EGFR_uc003tqh.2_Frame_Shift_Del_p.G288fs|EGFR_uc003tqi.2_Frame_Shift_Del_p.G288fs|EGFR_uc003tqj.2_Frame_Shift_Del_p.G288fs|EGFR_uc010kzg.1_Frame_Shift_Del_p.G243fs|EGFR_uc011kco.1_Frame_Shift_Del_p.G235fs|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	288_292	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289T(3)|p.A289D(3)|p.V292L(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TACAGCTTTGGTGCCACCTGCGTGAAGAAGTGT	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			---	---	---								-	55221831	-	-	55221819	7	5	232	1	0	1	0	1	0	0	0	0	4989	1261	44	0	889	0	EGFR	7	55221819	Frame_Shift_Del	DEL	GTGCCACCTGCGT	TCGA-CV-7236-01A-11D-2012-08	17233205	55221819	103916844	19	42085											
POM121	9883	broad.mit.edu	37	chr7	72418901	72418901	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccagcaagaacacagcccGaggaagggacccaataacct	16	2	9	14	1	0	1	0	0	0	1	0	4	0	3	4	2	4	1	4	2	5	1			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr7:72418901G>A	uc010lam.1	+	16	3933	c.2892G>A	c.(2890-2892)CCG>CCA	p.P964P	NSUN5P2_uc003twl.2_RNA|NSUN5P2_uc003twm.2_3'UTR|NSUN5P2_uc003twn.2_3'UTR|NSUN5P2_uc003two.2_3'UTR|NSUN5P2_uc003twq.2_3'UTR|NSUN5P2_uc010lan.1_3'UTR|NSUN5P2_uc003twp.2_3'UTR	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1003	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				AACACAGCCCGAGGAAGGGAC	0.488													14	85					0	0	0	0	A	72418901	A	A	72418901	2	1	232	1	0	0	0	0	0	0	0	1	12294	1073	37	1		1	POM121	7	72418901	Silent	SNP	G	TCGA-CV-7236-01A-11D-2012-08	17197082	72418901	86719762	20	42086											
ZNF777	27153	broad.mit.edu	37	chr7	149152729	149152729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggagcttcaggggagtgaaCgggggcttcctggtggtggg	6	8	21	6	1	1	1	1	1	0	0	2	3	2	3	1	8	2	2	1	8	1	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr7:149152729C>T	uc003wfv.2	-	2	548	c.385G>A	c.(385-387)GTT>ATT	p.V129I		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGGGAGTGAACGGGGGCTTCC	0.617													23	174					0	0	0	0	T	149152729	T	T	149152729	3	4	232	1	0	0	0	0	1	0	0	0	18217	536	19	1	2130	1	ZNF777	7	149152729	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08	76733828	149152729	9985934	21	42087											
ZNF775	285971	broad.mit.edu	37	chr7	150094922	150094922	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagttcatctgcaacgagtgCggcaagagcttctcgtggtg	8	10	13	10	3	3	1	1	0	2	1	4	2	3	1	0	2	4	4	0	2	2	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr7:150094922C>T	uc003whf.1	+	3	1478	c.1353C>T	c.(1351-1353)TGC>TGT	p.C451C	LOC728743_uc003whg.2_5'Flank	NM_173680	NP_775951	Q96BV0	ZN775_HUMAN	zinc finger protein 775	451	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCAACGAGTGCGGCAAGAGCT	0.731													5	14					0	0	0	0	T	150094922	T	T	150094922	2	4	232	1	0	0	0	0	0	0	0	1	18215	776	27	1		1	ZNF775	7	150094922	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08	942193	150094922	9043741	22	42088											
SLCO5A1	81796	broad.mit.edu	37	chr8	70585202	70585202	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccccgggtaggtctgtgctgCgcactggatccctttttgca	4	12	12	13	2	1	0	0	0	1	0	2	1	2	1	3	3	3	4	3	3	1	3			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr8:70585202C>T	uc003xyl.2	-	10	3156	c.2449G>A	c.(2449-2451)GCA>ACA	p.A817T	SLCO5A1_uc010lzb.2_Missense_Mutation_p.A762T|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	817						integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GTCTGTGCTGCGCACTGGATC	0.617													11	79					0	0	0	0	T	70585202	T	T	70585202	3	4	232	1	0	0	0	0	1	0	0	0	14795	768	27	1	101	1	SLCO5A1	8	70585202	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08		70585202	75778820	23	42089											
HNF4G	3174	broad.mit.edu	37	chr8	76471035	76471035	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctctcttattcctttgttaGatgcaaaagggctaagcgat	10	14	8	9	1	1	1	0	0	1	1	3	2	2	1	2	1	2	3	2	1	5	5			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr8:76471035G>A	uc003yaq.2	+	9	1016	c.746_splice	c.e9-1	p.D249_splice	HNF4G_uc003yar.2_Splice_Site_p.D286_splice	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma						endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TCCTTTGTTAGATGCAAAAGG	0.353													13	28					0	0	0	0	A	76471035	A	A	76471035	5	1	232	1	0	0	0	0	0	0	1	0	7293	956	33	2	886	2	HNF4G	8	76471035	Splice_Site	SNP	G	TCGA-CV-7236-01A-11D-2012-08	5885833	76471035	69892987	24	42090											
COL22A1	169044	broad.mit.edu	37	chr8	139824126	139824127	+	In_Frame_Ins	INS	-	GGTGGA	GGTGGA																															tgggaggccgctggggtgggINSggtggaggtggaggctctgt																										TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr8:139824126_139824127insGGTGGA	uc003yvd.2	-	9	1811_1812	c.1364_1365insTCCACC	c.(1363-1365)CCC>CCTCCACCC	p.455_455P>PPP		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	455	Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GCTGGGGTGGGGGTGGAGGTGG	0.599										HNSCC(7;0.00092)			---	---	---								GGTGGA	139824127	GGTGGA	GGTGGA	139824126	7	5	232	1	0	1	1	0	0	0	0	0	3696	1219	43	0	3743	0	COL22A1	8	139824126	In_Frame_Ins	INS	-	TCGA-CV-7236-01A-11D-2012-08	63353091	139824126	6539896	25	42091											
PLEC	5339	broad.mit.edu	37	chr8	144993755	144993755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caccacgcccgccttcacggCctcgtggacatacaggcgct	7	6	10	18	5	1	0	1	0	0	0	2	1	1	1	4	3	1	1	4	3	1	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr8:144993755C>T	uc003zaf.1	-	32	10815	c.10645G>A	c.(10645-10647)GCC>ACC	p.A3549T	PLEC_uc003zab.1_Missense_Mutation_p.A3412T|PLEC_uc003zac.1_Missense_Mutation_p.A3416T|PLEC_uc003zad.2_Missense_Mutation_p.A3412T|PLEC_uc003zae.1_Missense_Mutation_p.A3380T|PLEC_uc003zag.1_Missense_Mutation_p.A3390T|PLEC_uc003zah.2_Missense_Mutation_p.A3398T|PLEC_uc003zaj.2_Missense_Mutation_p.A3439T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3549	Plectin 13.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCTTCACGGCCTCGTGGACA	0.687													13	38					0	0	0	0	T	144993755	T	T	144993755	3	4	232	1	0	0	0	0	1	0	0	0	12107	739	26	4	3413	4	PLEC	8	144993755	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08	5169629	144993755	1370267	26	42092											
ZNF510	22869	broad.mit.edu	37	chr9	99521423	99521423	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctctcccgtgtgagttttCtgatgttgaatgagatgatc	7	17	10	7	1	2	5	0	5	2	1	5	6	3	5	1	0	0	2	1	0	1	4			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr9:99521423C>T	uc004awn.1	-	6	1878	c.1689G>A	c.(1687-1689)CAG>CAA	p.Q563Q	ZNF510_uc004awo.1_Silent_p.Q563Q	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	563	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				TGTGAGTTTTCTGATGTTGAA	0.423													9	120					0	0	0	0	T	99521423	T	T	99521423	2	4	232	1	0	0	0	0	0	0	0	1	18021	912	32	2		2	ZNF510	9	99521423	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08		99521423	41692008	27	42093											
GOLGA2	2801	broad.mit.edu	37	chr9	131019939	131019939	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcctccttctcccggtgccGctccttcagcactgccctct	2	12	6	21	2	3	0	1	0	2	0	7	0	6	0	6	1	3	2	6	1	0	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr9:131019939G>T	uc011maw.1	-	24	2591	c.2578C>A	c.(2578-2580)CGG>AGG	p.R860R	GOLGA2_uc010mxw.2_Silent_p.R183R|GOLGA2_uc004buh.2_Intron	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	860	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						TCCCGGTGCCGCTCCTTCAGC	0.622													19	202					1.33834e-09	1.70005e-09	1	0	T	131019939	T	T	131019939	2	4	232	1	0	0	0	0	0	0	0	1	6589	1086	38	3		3	GOLGA2	9	131019939	Silent	SNP	G	TCGA-CV-7236-01A-11D-2012-08	31498516	131019939	10193492	28	42094											
RAPGEF1	2889	broad.mit.edu	37	chr9	134458080	134458080	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcgatcagtgtgcagtactCggccaggccctggcaggaca	8	7	14	12	2	1	0	1	0	0	0	3	2	1	1	2	4	2	3	2	4	1	1			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr9:134458080C>T	uc004cbc.2	-	22	2996	c.2866G>A	c.(2866-2868)GAG>AAG	p.E956K	RAPGEF1_uc004cbb.2_Missense_Mutation_p.E974K	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	956	Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GTGCAGTACTCGGCCAGGCCC	0.562													19	90					0	0	0	0	T	134458080	T	T	134458080	3	4	232	1	0	0	0	0	1	0	0	0	13108	893	31	1	379	1	RAPGEF1	9	134458080	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08	3438141	134458080	6755351	29	42095											
NOTCH1	4851	broad.mit.edu	37	chr9	139412252	139412252	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatctggtccaggcaggtggCgtcgttctggcacgggttcg	5	10	16	10	4	2	0	0	0	2	0	5	0	3	0	1	6	0	4	1	6	1	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr9:139412252C>T	uc004chz.2	-	8	1393	c.1393G>A	c.(1393-1395)GCC>ACC	p.A465T		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	465	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGGCAGGTGGCGTCGTTCTGG	0.672			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			20	74					0	0	0	0	T	139412252	T	T	139412252	3	4	232	1	0	0	0	0	1	0	0	0	10601	768	27	1	6382	1	NOTCH1	9	139412252	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08	4954172	139412252	1801179	30	42096											
PLCE1	51196	broad.mit.edu	37	chr10	96014690	96014690	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccaaaccccctcccttcCagaagagcccactctttgac	9	8	4	20	0	1	3	0	1	1	2	4	3	4	3	7	0	2	0	7	0	2	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr10:96014690C>A	uc001kjk.2	+	11	4072	c.3438C>A	c.(3436-3438)TCC>TCA	p.S1146S	PLCE1_uc010qnx.1_Silent_p.S1146S|PLCE1_uc001kjm.2_Silent_p.S838S	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1146					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				CCCTCCCTTCCAGAAGAGCCC	0.532													21	200					2.70639e-06	3.34738e-06	1	0	A	96014690	A	A	96014690	2	1	232	1	0	0	0	0	0	0	0	1	12089	581	21	4		4	PLCE1	10	96014690	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08		96014690	39520057	31	42097											
MUC5B	727897	broad.mit.edu	37	chr11	1262890	1262890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctacaactacaggatcCgggtcctctgctgcagtgac	8	10	11	12	1	1	1	0	1	1	0	3	2	3	2	2	2	6	3	2	2	3	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr11:1262890C>T	uc009ycr.1	+	47	6985	c.6859C>T	c.(6859-6861)CGG>TGG	p.R2287W	MUC5B_uc001ltb.2_Missense_Mutation_p.R1597W	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1594	7 X Cys-rich subdomain repeats.|Cys-rich subdomain 2.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTACAGGATCCGGGTCCTCTG	0.637													4	27					0	0	0	0	T	1262890	T	T	1262890	3	4	232	1	0	0	0	0	1	0	0	0	10032	643	23	1	4911	1	MUC5B	11	1262890	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08		1262890	133743626	32	42098											
ZNF215	7762	broad.mit.edu	37	chr11	6977595	6977595	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttggaaacaatttctatCaatgtgttaactgtggaaaa	15	15	7	4	0	2	0	1	0	1	0	2	2	2	2	0	2	2	1	0	2	7	5			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr11:6977595C>T	uc001mey.2	+	7	1975	c.1387C>T	c.(1387-1389)CAA>TAA	p.Q463*	ZNF215_uc010raw.1_3'UTR|ZNF215_uc010rax.1_Nonsense_Mutation_p.Q225*|ZNF215_uc001mez.1_Intron	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	463	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CAATTTCTATCAATGTGTTAA	0.398													5	65					0	0	0	0	T	6977595	T	T	6977595	4	4	232	1	0	0	0	0	0	1	0	0	17838	827	29	2	1405	2	ZNF215	11	6977595	Nonsense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08	5714705	6977595	128028921	33	42099											
FSHB	2488	broad.mit.edu	37	chr11	30255210	30255210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagtgagagtgcccggctgtGctcaccatgcagattccttg	7	10	12	12	1	1	2	1	1	0	2	2	3	2	2	3	1	3	3	3	1	0	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr11:30255210G>A	uc001msl.2	+	3	322	c.253G>A	c.(253-255)GCT>ACT	p.A85T	FSHB_uc001msm.2_Missense_Mutation_p.A85T|FSHB_uc001msn.2_Missense_Mutation_p.A85T	NM_000510	NP_000501	P01225	FSHB_HUMAN	follicle stimulating hormone, beta polypeptide	85					cellular nitrogen compound metabolic process|female gamete generation|female pregnancy|ovarian follicle development|peptide hormone processing|progesterone biosynthetic process|spermatogenesis|transforming growth factor beta receptor signaling pathway	cytoplasm|extracellular region|soluble fraction	follicle-stimulating hormone activity|protein heterodimerization activity			ovary(3)	3					Follitropin beta(DB00066)|Thyrotropin Alfa(DB00024)|Urofollitropin(DB00094)	GCCCGGCTGTGCTCACCATGC	0.527													6	63					0	0	0	0	A	30255210	A	A	30255210	3	1	232	1	0	0	0	0	1	0	0	0	6106	1319	46	4	259	4	FSHB	11	30255210	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	23277615	30255210	104751306	34	42100											
OR1S1	219959	broad.mit.edu	37	chr11	57982768	57982768	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caattgctcttctgtaaccaCaacactctcccacacttctt	10	13	2	16	0	4	0	0	0	4	0	5	0	4	0	2	0	3	2	2	0	3	5			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr11:57982768C>A	uc010rkc.1	+	1	552	c.552C>A	c.(550-552)CAC>CAA	p.H184Q		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				TCTGTAACCACAACACTCTCC	0.438													35	117					1.22384e-17	1.5759e-17	1	0	A	57982768	A	A	57982768	3	1	232	1	0	0	0	0	1	0	0	0	11026	477	17	4	554	4	OR1S1	11	57982768	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08	27727558	57982768	77023748	35	42101											
MEN1	4221	broad.mit.edu	37	chr11	64572117	64572117	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtcctgacactgcaccctGgccggtgcccaggcccttgt	4	8	13	16	1	0	1	0	1	0	0	1	1	1	1	5	4	2	1	5	4	0	1			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr11:64572117G>A	uc001obj.2	-	10	1610	c.1537C>T	c.(1537-1539)CAG>TAG	p.Q513*	MAP4K2_uc001obh.2_5'Flank|MAP4K2_uc001obi.2_5'Flank|MAP4K2_uc010rnp.1_5'Flank|MEN1_uc001obk.2_Nonsense_Mutation_p.Q513*|MEN1_uc001obl.2_Nonsense_Mutation_p.Q473*|MEN1_uc001obm.2_Nonsense_Mutation_p.Q508*|MEN1_uc001obn.2_Nonsense_Mutation_p.Q513*|MEN1_uc001obo.2_Nonsense_Mutation_p.Q513*|MEN1_uc001obp.2_Nonsense_Mutation_p.Q508*|MEN1_uc001obq.2_Nonsense_Mutation_p.Q513*|MEN1_uc001obr.2_Nonsense_Mutation_p.Q513*	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	513					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						ACTGCACCCTGGCCGGTGCCC	0.736			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				3	32					0	0	0	0	A	64572117	A	A	64572117	4	1	232	1	0	0	0	0	0	1	0	0	9525	1357	47	4	314	4	MEN1	11	64572117	Nonsense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	6589349	64572117	70434399	36	42102											
RASSF8	11228	broad.mit.edu	37	chr12	26217656	26217656	+	Frame_Shift_Del	DEL	C	-	-																															gcagagtctgccccccttagCtaaactgaggcctcagattg																										TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr12:26217656delC	uc001rgx.2	+	3	550	c.329delC	c.(328-330)GCTfs	p.A110fs	RASSF8_uc001rgy.2_Frame_Shift_Del_p.A110fs|RASSF8_uc001rgz.2_Frame_Shift_Del_p.A110fs|RASSF8_uc009zjd.1_Frame_Shift_Del_p.A110fs|RASSF8_uc009zje.1_Frame_Shift_Del_p.A110fs	NM_007211	NP_009142	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family	110					signal transduction						0	Colorectal(261;0.0847)					CCCCCCTTAGCTAAACTGAGG	0.468													---	---	---								-	26217656	-	-	26217656	7	5	232	1	0	1	0	1	0	0	0	0	13157	797	28	0	335	0	RASSF8	12	26217656	Frame_Shift_Del	DEL	C	TCGA-CV-7236-01A-11D-2012-08		26217656	107634239	37	42103											
NCKAP5L	57701	broad.mit.edu	37	chr12	50191005	50191005	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcccctggcctggaggcCgccagggggtggcaggtgag	5	4	20	12	1	0	1	0	1	0	0	0	2	0	2	5	8	0	1	5	8	0	0	rs78047311		TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr12:50191005C>A	uc009zlk.2	-	8	840	c.638G>T	c.(637-639)CGG>CTG	p.R213L	NCKAP5L_uc001rvc.3_5'Flank|NCKAP5L_uc001rvb.2_5'UTR	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	209	Pro-rich.									central_nervous_system(1)	1						GCCTGGAGGCCGCCAGGGGGT	0.667													5	55					1.23904e-05	1.51259e-05	1	0	A	50191005	A	A	50191005	3	1	232	1	0	0	0	0	1	0	0	0	10278	652	23	3	3390	3	NCKAP5L	12	50191005	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08	23973349	50191005	83660890	38	42104											
C12orf56	115749	broad.mit.edu	37	chr12	64661051	64661051	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagccttttctgcaaggctGgcatgtgaataaagtacctg	10	11	12	8	0	1	1	0	1	1	0	1	2	1	2	2	3	3	4	2	3	5	4			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr12:64661051G>A	uc001ssa.3	-	11	1301	c.1301C>T	c.(1300-1302)CCA>CTA	p.P434L	uc001srx.2_Intron|C12orf56_uc001sry.2_Missense_Mutation_p.P176L|C12orf56_uc001srz.2_Missense_Mutation_p.P76L	NM_001099676	NP_001093146	Q8IXR9	CL056_HUMAN	hypothetical protein LOC115749	597											0			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		CTGCAAGGCTGGCATGTGAAT	0.353													4	17					0	0	0	0	A	64661051	A	A	64661051	3	1	232	1	0	0	0	0	1	0	0	0	1706	1348	47	4	91	4	C12orf56	12	64661051	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	14470046	64661051	69190844	39	42105											
MYBPC1	4604	broad.mit.edu	37	chr12	101988804	101988804	+	Translation_Start_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtttctgtcaactagtcGtggagggaaggagactcttt	8	12	15	6	1	3	1	1	0	2	1	4	4	3	3	0	5	1	1	0	5	3	3			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr12:101988804G>A	uc001tii.2	+	1	58	c.-44G>A	c.(-46--42)TCGTG>TCATG		MYBPC1_uc001tif.1_Translation_Start_Site|MYBPC1_uc001tig.2_Translation_Start_Site|MYBPC1_uc010svq.1_Translation_Start_Site|MYBPC1_uc001tih.2_Translation_Start_Site|MYBPC1_uc001tij.2_Translation_Start_Site|MYBPC1_uc010svr.1_Translation_Start_Site|MYBPC1_uc010svs.1_Translation_Start_Site|MYBPC1_uc010svt.1_Translation_Start_Site|MYBPC1_uc010svu.1_Translation_Start_Site|MYBPC1_uc001tik.2_Translation_Start_Site	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3						cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						TCAACTAGTCGTGGAGGGAAG	0.458													3	27					0	0	0	0	A	101988804	A	A	101988804	1	1	232	1	0	0	0	0	0	0	0	0	10064	1160	40	1		1	MYBPC1	12	101988804	Translation_Start_Site	SNP	G	TCGA-CV-7236-01A-11D-2012-08	37327753	101988804	31863091	40	42106											
SFRS9	8683	broad.mit.edu	37	chr12	120901793	120901793	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgtcatccagtttacgcaggGcatattccatgtcttctttt	7	17	7	10	1	3	0	1	0	2	0	5	0	5	0	2	1	1	3	2	1	2	7			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr12:120901793G>A	uc001tyi.2	-	3	628	c.482C>T	c.(481-483)GCC>GTC	p.A161V		NM_003769	NP_003760	Q13242	SRSF9_HUMAN	splicing factor, arginine/serine-rich 9	161	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|RNA binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTTACGCAGGGCATATTCCAT	0.488													5	192					0	0	0	0	A	120901793	A	A	120901793	3	1	232	1	0	0	0	0	1	0	0	0	14249	1203	42	4	191	4	SFRS9	12	120901793	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	18912989	120901793	12950102	41	42107											
NUPL1	9818	broad.mit.edu	37	chr13	25875965	25875965	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggctccaccaccgtggcCgccggcgggaccagcacagg	6	3	15	17	4	0	0	0	0	0	0	1	1	1	1	6	5	1	2	6	5	0	0			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr13:25875965C>T	uc001uqi.2	+	1	300	c.54C>T	c.(52-54)GCC>GCT	p.A18A	NUPL1_uc001uqg.1_Silent_p.A18A|NUPL1_uc001uqj.2_Silent_p.A18A	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	18	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		CCACCGTGGCCGCCGGCGGGA	0.667													4	34					0	0	0	0	T	25875965	T	T	25875965	2	4	232	1	0	0	0	0	0	0	0	1	10828	639	23	1		1	NUPL1	13	25875965	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08		25875965	89293913	42	42108											
GPC5	2262	broad.mit.edu	37	chr13	92346021	92346021	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccggtcgttggaagaactCtcggatgcaatgcatggaac	11	9	12	9	3	1	1	0	0	1	1	4	4	2	4	1	4	4	3	1	4	4	1			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr13:92346021C>T	uc010tif.1	+	3	1272	c.906C>T	c.(904-906)CTC>CTT	p.L302L		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	302						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TGGAAGAACTCTCGGATGCAA	0.493													17	76					0	0	0	0	T	92346021	T	T	92346021	2	4	232	1	0	0	0	0	0	0	0	1	6639	900	32	2		2	GPC5	13	92346021	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08	66470056	92346021	22823857	43	42109											
OR4N2	390429	broad.mit.edu	37	chr14	20296100	20296100	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggtggtcctcatcctcCgcttgcctttttgtggccca	3	14	9	15	1	1	0	1	0	0	0	5	0	5	0	6	3	1	1	6	3	0	3			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr14:20296100C>T	uc010tkv.1	+	1	493	c.493C>T	c.(493-495)CGC>TGC	p.R165C		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCTCATCCTCCGCTTGCCTTT	0.517													14	239					0	0	0	0	T	20296100	T	T	20296100	3	4	232	1	0	0	0	0	1	0	0	0	11131	652	23	1	495	1	OR4N2	14	20296100	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08		20296100	87053440	44	42110											
MYH7	4625	broad.mit.edu	37	chr14	23891477	23891477	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggtcgccctccagcttccGcttcgctcgctccaggtcca	4	9	9	19	4	0	0	0	0	0	0	7	0	4	0	5	2	1	4	5	2	0	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr14:23891477G>A	uc001wjx.2	-	25	3263	c.3157C>T	c.(3157-3159)CGG>TGG	p.R1053W		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1053	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCAGCTTCCGCTTCGCTCGC	0.582													9	61					0	0	0	0	A	23891477	A	A	23891477	3	1	232	1	0	0	0	0	1	0	0	0	10092	1086	38	1	2714	1	MYH7	14	23891477	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	3595377	23891477	83458063	45	42111											
PRKCH	5583	broad.mit.edu	37	chr14	61952305	61952305	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgtcgttttgatgaagcacGagctcgcttctatgctgcag	7	13	11	10	4	1	2	0	2	1	0	4	3	1	2	0	0	4	6	0	0	2	4			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr14:61952305G>A	uc001xfn.2	+	10	1669	c.1364G>A	c.(1363-1365)CGA>CAA	p.R455Q	PRKCH_uc010tsa.1_Missense_Mutation_p.R294Q|PRKCH_uc010tsb.1_Missense_Mutation_p.R23Q	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	455	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		GATGAAGCACGAGCTCGCTTC	0.433													40	215					0	0	0	0	A	61952305	A	A	61952305	3	1	232	1	0	0	0	0	1	0	0	0	12575	1058	37	1	1402	1	PRKCH	14	61952305	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	38060828	61952305	45397235	46	42112											
ABCD4	5826	broad.mit.edu	37	chr14	74757040	74757040	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaacccggagcaaggaggtCttgccagtgcccgtgttgcc	8	7	14	12	2	1	1	0	0	1	1	1	3	1	3	4	3	5	2	4	3	2	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr14:74757040C>T	uc001xpr.2	-	12	1433	c.1281G>A	c.(1279-1281)AAG>AAA	p.K427K	ABCD4_uc001xps.2_Silent_p.K268K|ABCD4_uc001xpt.2_Silent_p.K268K|ABCD4_uc010tur.1_Silent_p.K323K|ABCD4_uc001xpu.2_Silent_p.K164K	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	427	ABC transporter.|ATP (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		GCAAGGAGGTCTTGCCAGTGC	0.627											OREG0022800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	128					0	0	0	0	T	74757040	T	T	74757040	2	4	232	1	0	0	0	0	0	0	0	1	63	912	32	2		2	ABCD4	14	74757040	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08	12804735	74757040	32592500	47	42113											
CASC5	57082	broad.mit.edu	37	chr15	40954309	40954309	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattctatctaaagtgccaCtggagaacaactacctgaag	14	9	7	11	0	2	2	0	1	2	1	2	3	2	2	3	1	4	0	3	1	7	4			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr15:40954309C>T	uc010bbs.1	+	27	7113	c.6952C>T	c.(6952-6954)CTG>TTG	p.L2318L	CASC5_uc010bbt.1_Silent_p.L2292L	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	2318					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TAAAGTGCCACTGGAGAACAA	0.328													17	84					0	0	0	0	T	40954309	T	T	40954309	2	4	232	1	0	0	0	0	0	0	0	1	2675	564	20	4		4	CASC5	15	40954309	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08		40954309	61577083	48	42114											
ABHD2	11057	broad.mit.edu	37	chr15	89698752	89698752	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgaattgacctcgccacgCatgttcacctatggtaagca	11	11	8	11	2	1	2	1	2	0	0	2	2	1	2	3	1	1	4	3	1	3	5			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr15:89698752C>T	uc002bnj.2	+	10	1442	c.525C>T	c.(523-525)CGC>CGT	p.R175R	ABHD2_uc002bnk.2_Silent_p.R175R	NM_007011	NP_008942	P08910	ABHD2_HUMAN	alpha/beta hydrolase domain containing protein	175						integral to membrane	carboxylesterase activity			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					CCTCGCCACGCATGTTCACCT	0.483													27	96					0	0	0	0	T	89698752	T	T	89698752	2	4	232	1	0	0	0	0	0	0	0	1	82	697	25	4		4	ABHD2	15	89698752	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08	48744443	89698752	12832640	49	42115											
TP53	7157	broad.mit.edu	37	chr17	7578503	7578503	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatcaacccacagctgcaCagggcaggtcttggccagtt	10	7	12	12	0	2	0	1	0	1	0	2	1	2	1	2	4	3	4	2	4	2	2			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr17:7578503C>T	uc002gim.2	-	5	621	c.427G>A	c.(427-429)GTG>ATG	p.V143M	TP53_uc002gig.1_Missense_Mutation_p.V143M|TP53_uc002gih.2_Missense_Mutation_p.V143M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V11M|TP53_uc010cng.1_Missense_Mutation_p.V11M|TP53_uc002gii.1_Missense_Mutation_p.V11M|TP53_uc010cnh.1_Missense_Mutation_p.V143M|TP53_uc010cni.1_Missense_Mutation_p.V143M|TP53_uc002gij.2_Missense_Mutation_p.V143M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V50M|TP53_uc002gio.2_Missense_Mutation_p.V11M|TP53_uc010vug.1_Missense_Mutation_p.V104M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	143	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius).|V -> E (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V143M(16)|p.V143A(14)|p.0?(7)|p.V143E(4)|p.V143L(4)|p.V143V(2)|p.V143fs*27(2)|p.L137_W146del10(1)|p.V143fs*29(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.A138_V143delAKTCPV(1)|p.V143G(1)|p.V143_S149del(1)|p.C141fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACAGCTGCACAGGGCAGGTC	0.587		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	46					0	0	0	0	T	7578503	T	T	7578503	3	4	232	1	0	0	0	0	1	0	0	0	16448	478	17	4	871	4	TP53	17	7578503	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08		7578503	73616707	50	42116											
TBC1D3B	414059	broad.mit.edu	37	chr17	34497333	34497333	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatagaggaggaacaaggCggcgatgtggctcaggtccc	13	5	15	8	2	1	1	1	0	0	1	2	4	2	3	1	6	1	1	1	6	5	1			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr17:34497333C>T	uc002hky.2	-	9	733	c.583G>A	c.(583-585)GCC>ACC	p.A195T	uc002khr.2_5'Flank|uc002hlc.2_5'Flank	NM_001001417	NP_001001417	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3B	195	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGAACAAGGCGGCGATGTGG	0.602													12	191					0	0	0	0	T	34497333	T	T	34497333	3	4	232	1	0	0	0	0	1	0	0	0	15686	768	27	1	1090	1	TBC1D3B	17	34497333	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08	26918830	34497333	46697877	51	42117											
GRIN2C	2905	broad.mit.edu	37	chr17	72851194	72851194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcccaggcaccgaagagcGaggtgagcaacagggccggc	10	2	16	13	3	0	2	0	1	0	1	0	4	0	2	3	4	4	2	3	4	2	0			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr17:72851194G>A	uc002jlt.1	-	2	194	c.38C>T	c.(37-39)TCG>TTG	p.S13L	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.S13L|GRIN2C_uc002jlv.1_Missense_Mutation_p.S13L	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	13					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	ACCGAAGAGCGAGGTGAGCAA	0.682													12	35					0	0	0	0	A	72851194	A	A	72851194	3	1	232	1	0	0	0	0	1	0	0	0	6820	1059	37	1	3711	1	GRIN2C	17	72851194	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	38353861	72851194	8344016	52	42118											
NETO1	81832	broad.mit.edu	37	chr18	70532113	70532113	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgggagaggtaaagataccTccctctgcatgttttgtcca	9	13	10	9	0	1	2	0	0	1	2	3	3	3	2	3	2	2	3	3	2	3	5			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr18:70532113T>C	uc002lkw.2	-	3	434	c.150A>G	c.(148-150)GGA>GGG	p.G50G	NETO1_uc002lkx.1_Silent_p.G49G|NETO1_uc002lky.1_Silent_p.G50G|NETO1_uc002lkz.2_Silent_p.G49G	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	50	CUB 1.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TAAAGATACCTCCCTCTGCAT	0.423													8	40					0	0	0	0	C	70532113	C	C	70532113	2	2	232	1	0	0	0	0	0	0	0	1	10393	1538	54	5		5	NETO1	18	70532113	Silent	SNP	T	TCGA-CV-7236-01A-11D-2012-08		70532113	7545135	53	42119											
MED16	10025	broad.mit.edu	37	chr19	873494	873494	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tacagcacgaagtcgcccacCcactgcaagagctgctgcag	11	5	10	15	2	0	1	0	0	0	1	1	2	0	1	2	0	6	5	2	0	3	1			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:873494C>G	uc002lqd.1	-	11	2011	c.1860G>C	c.(1858-1860)TGG>TGC	p.W620C	MED16_uc010drw.1_Missense_Mutation_p.W445C|MED16_uc002lqe.2_Missense_Mutation_p.W609C|MED16_uc002lqf.2_Missense_Mutation_p.W609C|MED16_uc010xfv.1_RNA|MED16_uc010xfw.1_Missense_Mutation_p.W540C|MED16_uc010xfx.1_Missense_Mutation_p.W465C|MED16_uc010xfy.1_Missense_Mutation_p.W197C	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	620					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCGCCCACCCACTGCAAGA	0.597													4	84					0	0	0	0	G	873494	G	G	873494	3	3	232	1	0	0	0	0	1	0	0	0	9487	624	22	4	797	4	MED16	19	873494	Missense_Mutation	SNP	C	TCGA-CV-7236-01A-11D-2012-08		873494	58255489	54	42120											
BEST2	54831	broad.mit.edu	37	chr19	12866479	12866479	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggcttgcctcattggtcgCcagttcctggacccggctca	4	11	11	15	2	2	0	2	0	0	0	4	1	3	1	4	4	1	3	4	4	0	3			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:12866479C>T	uc002mux.2	+	6	765	c.765C>T	c.(763-765)CGC>CGT	p.R255R		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	255	Extracellular (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						TCATTGGTCGCCAGTTCCTGG	0.607													16	88					0	0	0	0	T	12866479	T	T	12866479	2	4	232	1	0	0	0	0	0	0	0	1	1407	726	26	4		4	BEST2	19	12866479	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08	11992985	12866479	46262504	55	42121											
MEGF8	1954	broad.mit.edu	37	chr19	42847639	42847639	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcccctaggccgagcagcGcctcccagtggtcggtactc	6	8	11	16	3	0	0	0	0	0	0	4	1	2	0	5	3	3	2	5	3	2	3			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:42847639G>A	uc002otl.3	+	9	2159	c.1524G>A	c.(1522-1524)GCG>GCA	p.A508A	MEGF8_uc002otm.3_Silent_p.A49A	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	508	Extracellular (Potential).|Kelch 5.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GCCGAGCAGCGCCTCCCAGTG	0.642													7	59					0	0	0	0	A	42847639	A	A	42847639	2	1	232	1	0	0	0	0	0	0	0	1	9516	1074	38	1		1	MEGF8	19	42847639	Silent	SNP	G	TCGA-CV-7236-01A-11D-2012-08	29981160	42847639	16281344	56	42122											
LIPE	3991	broad.mit.edu	37	chr19	42914528	42914528	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tactcccggaggaagtcggcGgtgagcccctcgtcgccctc	5	7	13	16	5	0	1	0	1	0	0	5	3	1	3	4	4	2	0	4	4	2	1	rs151324837	byFrequency	TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:42914528G>C	uc002otr.2	-	2	1627	c.1350C>G	c.(1348-1350)ACC>ACG	p.T450T	uc010eif.1_Intron|LIPE_uc002ots.1_Silent_p.T195T	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	450					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				GGAAGTCGGCGGTGAGCCCCT	0.667													3	26					0	0	0	0	C	42914528	C	C	42914528	2	2	232	1	0	0	0	0	0	0	0	1	8863	1103	39	3		3	LIPE	19	42914528	Silent	SNP	G	TCGA-CV-7236-01A-11D-2012-08	66889	42914528	16214455	57	42123											
MARK4	57787	broad.mit.edu	37	chr19	45762439	45762439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggctcggcacatcctcactGgtcgggaggtgagtatgggc	6	9	16	10	2	1	1	1	1	0	0	4	2	2	2	1	6	0	3	1	6	1	1			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:45762439G>A	uc002pbb.1	+	2	249	c.244G>A	c.(244-246)GGT>AGT	p.G82S	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Missense_Mutation_p.G82S			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	82	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CATCCTCACTGGTCGGGAGGT	0.617													3	27					0	0	0	0	A	45762439	A	A	45762439	3	1	232	1	0	0	0	0	1	0	0	0	9368	1348	47	4	250	4	MARK4	19	45762439	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	2847911	45762439	13366544	58	42124											
MYH14	79784	broad.mit.edu	37	chr19	50805052	50805052	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggatgctggggcccgtgcCcgccacaagatgaccattgc	8	6	14	13	2	0	2	0	1	0	1	0	4	0	3	4	3	3	1	4	3	1	1			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:50805052C>T	uc002prr.1	+	38	5528	c.5481C>T	c.(5479-5481)GCC>GCT	p.A1827A	MYH14_uc010enu.1_Silent_p.A1868A|MYH14_uc002prq.1_Silent_p.A1835A|MYH14_uc010ycb.1_Silent_p.A178A|MYH14_uc002prs.1_Silent_p.A178A	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1827	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GGGCCCGTGCCCGCCACAAGA	0.637													6	33					0	0	0	0	T	50805052	T	T	50805052	2	4	232	1	0	0	0	0	0	0	0	1	10086	610	22	4		4	MYH14	19	50805052	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08	5042613	50805052	8323931	59	42125											
C19orf51	352909	broad.mit.edu	37	chr19	55670685	55670685	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgcccagagctgattcctgGgacttgcagaaacgtgcgaa	10	9	12	10	2	0	3	0	1	0	2	1	5	1	4	2	1	5	2	2	1	2	3			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr19:55670685G>A	uc002qji.1	-	12	1405	c.1371C>T	c.(1369-1371)TCC>TCT	p.S457S	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Silent_p.S272S|C19orf51_uc002qjj.1_Silent_p.S504S|C19orf51_uc002qjk.1_Silent_p.S403S|C19orf51_uc002qjl.1_Silent_p.S524S			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	457											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CTGATTCCTGGGACTTGCAGA	0.612													9	51					0	0	0	0	A	55670685	A	A	55670685	2	1	232	1	0	0	0	0	0	0	0	1	1942	1219	43	4		4	C19orf51	19	55670685	Silent	SNP	G	TCGA-CV-7236-01A-11D-2012-08	4865633	55670685	3458298	60	42126											
DNMT3B	1789	broad.mit.edu	37	chr20	31385069	31385069	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgtgtgctgcgagggccGagagctgctgctttgcagca	6	9	15	11	2	0	1	0	0	0	1	0	3	0	1	1	1	7	6	1	1	0	1			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr20:31385069G>T	uc002wyc.2	+	14	1775	c.1454G>T	c.(1453-1455)CGA>CTA	p.R485L	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Missense_Mutation_p.R465L|DNMT3B_uc002wye.2_Missense_Mutation_p.R465L|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.R423L|DNMT3B_uc010zua.1_Missense_Mutation_p.R389L|DNMT3B_uc002wyf.2_Missense_Mutation_p.R477L|DNMT3B_uc002wyg.2_Missense_Mutation_p.R184L	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	485	PHD-type; atypical.|Interaction with the PRC2/EED-EZH2 complex (By similarity).|ADD.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						TGCGAGGGCCGAGAGCTGCTG	0.587													16	117					1.3612e-06	1.70604e-06	1	0	T	31385069	T	T	31385069	3	4	232	1	0	0	0	0	1	0	0	0	4699	1058	37	3	1544	3	DNMT3B	20	31385069	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08		31385069	31640451	61	42127											
ZMYND8	23613	broad.mit.edu	37	chr20	45839455	45839455	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcgggaggaggctcttcGtgctggtactggtgttgtga	4	14	16	7	2	1	1	0	1	1	0	3	3	1	3	0	5	2	4	0	5	1	4	rs146133202		TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr20:45839455G>A	uc002xta.1	-	22	3766	c.3512C>T	c.(3511-3513)ACG>ATG	p.T1171M	ZMYND8_uc010ghq.1_Nonsense_Mutation_p.R808*|ZMYND8_uc010ghr.1_Missense_Mutation_p.T1101M|ZMYND8_uc002xst.1_Missense_Mutation_p.T1053M|ZMYND8_uc002xsu.1_Missense_Mutation_p.T1072M|ZMYND8_uc002xsv.1_Missense_Mutation_p.T1099M|ZMYND8_uc002xsw.1_Missense_Mutation_p.T905M|ZMYND8_uc002xsx.1_Missense_Mutation_p.T877M|ZMYND8_uc002xsy.1_Missense_Mutation_p.T1128M|ZMYND8_uc002xsz.1_Missense_Mutation_p.T1090M|ZMYND8_uc010zxy.1_Missense_Mutation_p.T1226M|ZMYND8_uc002xtb.1_Missense_Mutation_p.T1173M|ZMYND8_uc002xss.2_Missense_Mutation_p.T1171M|ZMYND8_uc010zxz.1_Missense_Mutation_p.T1039M|ZMYND8_uc002xtc.1_Missense_Mutation_p.T1145M|ZMYND8_uc002xtd.1_Missense_Mutation_p.T1120M|ZMYND8_uc002xte.1_Missense_Mutation_p.T1153M|ZMYND8_uc010zya.1_Missense_Mutation_p.T1199M|ZMYND8_uc002xtf.1_Missense_Mutation_p.T1219M|ZMYND8_uc002xsr.1_Missense_Mutation_p.T270M	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	1171	Interacts with PRKCB1.						protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GAGGCTCTTCGTGCTGGTACT	0.542													10	89					0	0	0	0	A	45839455	A	A	45839455	3	1	232	1	0	0	0	0	1	0	0	0	17778	1145	40	1	52	1	ZMYND8	20	45839455	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	14454386	45839455	17186065	62	42128											
HIC2	23119	broad.mit.edu	37	chr22	21799898	21799898	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcagcaccaacgggagcagCgggggctgcgagcaggagct	10	2	18	11	3	0	0	0	0	0	0	0	3	0	2	1	4	8	6	1	4	1	0			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr22:21799898C>T	uc002zur.3	+	3	944	c.714C>T	c.(712-714)AGC>AGT	p.S238S	HIC2_uc002zus.3_Silent_p.S238S	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	238					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				ACGGGAGCAGCGGGGGCTGCG	0.697													6	34					0	0	0	0	T	21799898	T	T	21799898	2	4	232	1	0	0	0	0	0	0	0	1	7141	767	27	1		1	HIC2	22	21799898	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08		21799898	29504668	63	42129											
C22orf36	388886	broad.mit.edu	37	chr22	24982181	24982181	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagctgggtgaggcggggCagcgcccacaggctgggcag	7	3	21	10	2	0	1	0	1	0	0	0	2	0	2	1	7	2	4	1	7	0	0	rs111248278		TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chr22:24982181C>T	uc003aaq.2	-	4	650	c.621G>A	c.(619-621)CTG>CTA	p.L207L	GGT1_uc003aan.1_Intron|C22orf36_uc003aao.2_RNA|C22orf36_uc003aap.2_RNA	NM_207644	NP_997527	Q2VPJ9	LRC6X_HUMAN	hypothetical protein LOC388886	207	LRR 2.										0						TGAGGCGGGGCAGCGCCCACA	0.652													27	95					0	0	0	0	T	24982181	T	T	24982181	2	4	232	1	0	0	0	0	0	0	0	1	2156	697	25	4		4	C22orf36	22	24982181	Silent	SNP	C	TCGA-CV-7236-01A-11D-2012-08	3182283	24982181	26322385	64	42130											
WNK3	65267	broad.mit.edu	37	chrX	54263432	54263434	+	In_Frame_Del	DEL	CAC	-	-																															ctctatttctgattcatcatCactgctcattggggaagatg																										TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chrX:54263432_54263434delCAC	uc004dtd.1	-	20	4863_4865	c.4424_4426delGTG	c.(4423-4428)AGTGAT>AAT	p.1475_1476SD>N	WNK3_uc004dtc.1_In_Frame_Del_p.1522_1523SD>N	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1475_1476					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GATTCATCATCACTGCTCATTGG	0.433													---	---	---								-	54263434	-	-	54263432	7	5	232	1	0	1	0	1	0	0	0	0	17447	826	29	0	855	0	WNK3	23	54263432	In_Frame_Del	DEL	CAC	TCGA-CV-7236-01A-11D-2012-08		54263432	101007128	65	42131											
P2RY10	27334	broad.mit.edu	37	chrX	78217018	78217018	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cctcatgagcaaggagagtgGttcatcaatgattggctaaa	13	10	11	7	0	3	3	3	2	0	1	3	4	3	3	1	3	1	3	1	3	4	3			TCGA-CV-7236-01A-11D-2012-08	TCGA-CV-7236-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc220a9d-1f16-4fe3-8196-d837a909f038	360144da-2c0b-4e18-81b5-5dde9d7a3682	g.chrX:78217018G>C	uc004ede.2	+	4	1370	c.1001G>C	c.(1000-1002)GGT>GCT	p.G334A	P2RY10_uc004edf.2_Missense_Mutation_p.G334A	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	334	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						AAGGAGAGTGGTTCATCAATG	0.418													18	133					0	0	0	0	C	78217018	C	C	78217018	3	2	232	1	0	0	0	0	1	0	0	0	11401	1261	44	4	1003	4	P2RY10	23	78217018	Missense_Mutation	SNP	G	TCGA-CV-7236-01A-11D-2012-08	23953586	78217018	77053542	66	42132											
MASP2	10747	broad.mit.edu	37	chr1	11087433	11087433	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcaaagccagcatcatgagTataaccttcatgtataaaaa	17	10	6	8	0	3	1	3	1	0	0	3	1	3	1	2	0	3	3	2	0	7	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr1:11087433T>C	uc001aru.2	-	11	1591	c.1570A>G	c.(1570-1572)ACT>GCT	p.T524A		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	524	Peptidase S1.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		GCATCATGAGTATAACCTTCA	0.398													15	154					0	0	0	0	C	11087433	C	C	11087433	3	2	233	1	0	0	0	0	1	0	0	0	9376	1638	57	5	494	5	MASP2	1	11087433	Missense_Mutation	SNP	T	TCGA-CV-7238-01A-11D-2012-08		11087433	238163188	1	42133											
PTCHD2	57540	broad.mit.edu	37	chr1	11580836	11580836	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactcttccggcctgataccAacatccaggtgctgctggac	8	10	9	14	1	1	1	0	1	1	0	3	2	3	2	4	3	5	2	4	3	3	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr1:11580836A>G	uc001ash.3	+	10	2431	c.2293A>G	c.(2293-2295)AAC>GAC	p.N765D	PTCHD2_uc001asi.1_Missense_Mutation_p.N765D	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	765	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GCCTGATACCAACATCCAGGT	0.642													3	20					0	0	0	0	G	11580836	G	G	11580836	3	3	233	1	0	0	0	0	1	0	0	0	12795	130	5	5	2327	5	PTCHD2	1	11580836	Missense_Mutation	SNP	A	TCGA-CV-7238-01A-11D-2012-08	493403	11580836	237669785	2	42134											
ARID1A	8289	broad.mit.edu	37	chr1	27100152	27100152	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgccttccaacccagactcGgggatgtattctcctagccg	8	10	9	14	2	1	1	0	0	1	1	4	2	2	2	5	2	3	1	5	2	3	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr1:27100152G>A	uc001bmv.1	+	16	4321	c.3948G>A	c.(3946-3948)TCG>TCA	p.S1316S	ARID1A_uc001bmt.1_Silent_p.S1315S|ARID1A_uc001bmu.1_Silent_p.S1316S|ARID1A_uc001bmw.1_Silent_p.S933S|ARID1A_uc001bmx.1_Silent_p.S162S|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1316					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.M1318fs*163(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ACCCAGACTCGGGGATGTATT	0.507			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								11	52					0	0	0	0	A	27100152	A	A	27100152	2	1	233	1	0	0	0	0	0	0	0	1	913	1103	39	1		1	ARID1A	1	27100152	Silent	SNP	G	TCGA-CV-7238-01A-11D-2012-08	15519316	27100152	222150469	3	42135											
CSF3R	1441	broad.mit.edu	37	chr1	36937036	36937036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgccagccccctttacctCtgctttctgagaagaccacc	7	10	7	17	0	2	2	0	1	2	2	2	3	2	2	6	0	4	2	6	0	2	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr1:36937036C>T	uc001caw.1	-	10	1461	c.1283G>A	c.(1282-1284)AGA>AAA	p.R428K	CSF3R_uc001cat.1_5'Flank|CSF3R_uc009vvc.1_5'UTR|CSF3R_uc001cau.1_5'UTR|CSF3R_uc001cav.1_Missense_Mutation_p.R428K|CSF3R_uc001cax.1_Missense_Mutation_p.R428K|CSF3R_uc001cay.1_Missense_Mutation_p.R428K	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	428	Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CCCTTTACCTCTGCTTTCTGA	0.368													15	146					0	0	0	0	T	36937036	T	T	36937036	3	4	233	1	0	0	0	0	1	0	0	0	3954	913	32	2	1449	2	CSF3R	1	36937036	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	9836884	36937036	212313585	4	42136											
ZNHIT6	54680	broad.mit.edu	37	chr1	86173364	86173364	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgggtgatttatcggaggctCttctttcacctttgtatcat	6	17	9	9	2	4	1	2	1	2	0	5	2	4	2	1	3	0	2	1	3	2	6			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr1:86173364C>T	uc001dlh.2	-	1	738	c.604G>A	c.(604-606)GAG>AAG	p.E202K	ZNHIT6_uc010osc.1_Missense_Mutation_p.E163K	NM_017953	NP_060423	Q9NWK9	BCD1_HUMAN	zinc finger, HIT type 6	202	Glu-rich.				box C/D snoRNP assembly|ribosome biogenesis	pre-snoRNP complex	identical protein binding|metal ion binding			large_intestine(1)	1						ATCGGAGGCTCTTCTTTCACC	0.463													8	153					0	0	0	0	T	86173364	T	T	86173364	3	4	233	1	0	0	0	0	1	0	0	0	18276	922	32	2	848	2	ZNHIT6	1	86173364	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	49236328	86173364	163077257	5	42137											
RPRD2	23248	broad.mit.edu	37	chr1	150416840	150416840	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtgcagcacagaaactctCaaatgcttaaaaggtaatgc	15	9	9	8	0	1	1	1	0	1	1	2	1	1	1	0	1	5	4	0	1	5	2			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr1:150416840C>G	uc009wlr.2	+	6	882	c.681C>G	c.(679-681)CTC>CTG	p.L227L	RPRD2_uc010pcc.1_Silent_p.L201L|RPRD2_uc001eup.3_Silent_p.L201L	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	227							protein binding			ovary(1)	1						CAGAAACTCTCAAATGCTTAA	0.383													3	60					0	0	0	0	G	150416840	G	G	150416840	2	3	233	1	0	0	0	0	0	0	0	1	13682	813	29	2		2	RPRD2	1	150416840	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08	64243476	150416840	98833781	6	42138											
C2orf16	84226	broad.mit.edu	37	chr2	27801709	27801709	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggaggactttgggattctgGgatacaggaagtatccagag	12	9	15	5	0	1	1	0	0	1	1	2	6	2	6	1	5	1	1	1	5	3	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr2:27801709G>A	uc002rkz.3	+	1	2321	c.2270G>A	c.(2269-2271)GGG>GAG	p.G757E		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	757										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					TGGGATTCTGGGATACAGGAA	0.418													11	144					0	0	0	0	A	27801709	A	A	27801709	3	1	233	1	0	0	0	0	1	0	0	0	2167	1232	43	4	2272	4	C2orf16	2	27801709	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08		27801709	215397664	7	42139											
NMS	129521	broad.mit.edu	37	chr2	101097598	101097598	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatgttgcaggatcacactgCgacctggggacgaccctttt	8	11	11	11	2	1	0	1	0	0	0	1	4	1	2	2	3	2	2	2	3	1	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr2:101097598C>T	uc002tan.1	+	8	390	c.383C>T	c.(382-384)GCG>GTG	p.A128V		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	128					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						GATCACACTGCGACCTGGGGA	0.393													9	142					0	0	0	0	T	101097598	T	T	101097598	3	4	233	1	0	0	0	0	1	0	0	0	10556	768	27	1	413	1	NMS	2	101097598	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	73295889	101097598	142101775	8	42140											
SCN9A	6335	broad.mit.edu	37	chr2	167142859	167142859	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtacctgattgggggtaGacaacctcttttcatgtgct	7	14	12	8	0	2	2	1	1	1	1	2	2	2	2	2	3	3	3	2	3	3	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr2:167142859G>A	uc010fpl.2	-	11	1930	c.1589C>T	c.(1588-1590)TCT>TTT	p.S530F	uc002udp.2_Intron|SCN9A_uc002udr.1_Missense_Mutation_p.S401F|SCN9A_uc002uds.1_Missense_Mutation_p.S401F|SCN9A_uc002udt.1_Missense_Mutation_p.S401F	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	530						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	ATTGGGGGTAGACAACCTCTT	0.448													23	277					0	0	0	0	A	167142859	A	A	167142859	3	1	233	1	0	0	0	0	1	0	0	0	13990	942	33	2	4412	2	SCN9A	2	167142859	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	66045261	167142859	76056514	9	42141											
CASP10	843	broad.mit.edu	37	chr2	202093772	202093772	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catctctgcgcagacacctcGaccccccatgcgcaggtgga	8	6	10	17	3	1	1	0	0	1	1	3	3	1	2	4	2	2	2	4	2	0	0	rs151011448		TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr2:202093772G>A	uc002uxl.1	+	10	1950	c.1532G>A	c.(1531-1533)CGA>CAA	p.R511Q	CASP10_uc002uxm.1_Missense_Mutation_p.R468Q	NM_032974	NP_116756	Q92851	CASPA_HUMAN	caspase 10 isoform b preproprotein	511					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			skin(3)|ovary(1)|pancreas(1)|breast(1)	6						CAGACACCTCGACCCCCCATG	0.567													11	147					0	0	0	0	A	202093772	A	A	202093772	3	1	233	1	0	0	0	0	1	0	0	0	2681	1058	37	1	1724	1	CASP10	2	202093772	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	34950913	202093772	41105601	10	42142											
CADPS	8618	broad.mit.edu	37	chr3	62578331	62578331	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgcccaagctccttgtccTccaacgccaggacgcctgtg	6	7	9	19	3	0	0	0	0	0	0	3	1	3	1	7	1	2	1	7	1	2	1			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr3:62578331T>C	uc003dll.2	-	7	1778	c.1418A>G	c.(1417-1419)GAG>GGG	p.E473G	CADPS_uc003dlm.2_Missense_Mutation_p.E473G|CADPS_uc003dln.2_Missense_Mutation_p.E473G	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	473	C2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CTCCTTGTCCTCCAACGCCAG	0.562													3	86					0	0	0	0	C	62578331	C	C	62578331	3	2	233	1	0	0	0	0	1	0	0	0	2582	1551	54	5	2812	5	CADPS	3	62578331	Missense_Mutation	SNP	T	TCGA-CV-7238-01A-11D-2012-08		62578331	135444099	11	42143											
ADAMTS9	56999	broad.mit.edu	37	chr3	64582598	64582598	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctctccacacagtcgtttgCggtgtatccattttcatcct	6	16	6	13	2	2	0	1	0	1	0	7	0	5	0	3	1	1	2	3	1	1	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr3:64582598C>T	uc003dmg.2	-	27	4119	c.4087G>A	c.(4087-4089)GCA>ACA	p.A1363T	ADAMTS9_uc011bfo.1_Missense_Mutation_p.A1335T|ADAMTS9_uc003dmh.1_Missense_Mutation_p.A1192T|ADAMTS9_uc011bfp.1_Missense_Mutation_p.A274T	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1363	TSP type-1 9.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CAGTCGTTTGCGGTGTATCCA	0.507													12	69					0	0	0	0	T	64582598	T	T	64582598	3	4	233	1	0	0	0	0	1	0	0	0	273	768	27	1	1772	1	ADAMTS9	3	64582598	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	2004267	64582598	133439832	12	42144											
CNTN3	5067	broad.mit.edu	37	chr3	74350658	74350658	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acccatgggtttaactcaacTacagtggctgtgtgcgtctt	8	13	10	10	1	2	0	1	0	1	0	2	0	2	0	1	2	4	2	1	2	3	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr3:74350658T>A	uc003dpm.1	-	15	2066	c.1986A>T	c.(1984-1986)GTA>GTT	p.V662V		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	662	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TTAACTCAACTACAGTGGCTG	0.433													8	76					0	0	0	0	A	74350658	A	A	74350658	2	1	233	1	0	0	0	0	0	0	0	1	3657	1509	53	5		5	CNTN3	3	74350658	Silent	SNP	T	TCGA-CV-7238-01A-11D-2012-08	9768060	74350658	123671772	13	42145											
TRH	7200	broad.mit.edu	37	chr3	129695951	129695951	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggagcctatggtcaagcgggCcttctgctggggctcctgga	5	9	16	11	1	2	0	1	0	1	0	3	2	3	2	3	6	3	2	3	6	2	2			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr3:129695951C>T	uc003enc.2	+	3	1182	c.621C>T	c.(619-621)GGC>GGT	p.G207G		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	207					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						GTCAAGCGGGCCTTCTGCTGG	0.622													6	37					0	0	0	0	T	129695951	T	T	129695951	2	4	233	1	0	0	0	0	0	0	0	1	16545	726	26	4		4	TRH	3	129695951	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08	55345293	129695951	68326479	14	42146											
COL6A6	131873	broad.mit.edu	37	chr3	130281957	130281957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttggtggacagctctgatcGcctgggatccaagtccttcc	6	12	11	12	1	1	1	0	1	1	0	5	3	4	3	4	3	1	1	4	3	1	2			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr3:130281957G>A	uc010htl.2	+	2	141	c.110G>A	c.(109-111)CGC>CAC	p.R37H		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	37	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AGCTCTGATCGCCTGGGATCC	0.458													14	180					0	0	0	0	A	130281957	A	A	130281957	3	1	233	1	0	0	0	0	1	0	0	0	3718	1087	38	1	116	1	COL6A6	3	130281957	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	586006	130281957	67740473	15	42147											
COPB2	9276	broad.mit.edu	37	chr3	139078167	139078167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggcagcttctggcagccGtccagttctaattaagagct	10	10	11	10	1	2	1	0	0	2	1	3	2	3	1	2	2	3	5	2	2	3	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr3:139078167G>A	uc003etf.3	-	18	2378	c.2248C>T	c.(2248-2250)CGG>TGG	p.R750W	COPB2_uc011bmv.1_Missense_Mutation_p.R721W|COPB2_uc010hui.2_Missense_Mutation_p.R721W	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	750	WD 9.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						TCTGGCAGCCGTCCAGTTCTA	0.393													15	113					0	0	0	0	A	139078167	A	A	139078167	3	1	233	1	0	0	0	0	1	0	0	0	3744	1144	40	1	492	1	COPB2	3	139078167	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	8796210	139078167	58944263	16	42148											
GFM1	85476	broad.mit.edu	37	chr3	158402350	158402350	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgagaagggccctctttctgGtcacaagctctctgggctcc	6	10	11	14	1	4	1	1	0	3	1	6	2	5	1	2	3	1	2	2	3	2	1			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr3:158402350G>C	uc003fce.2	+	15	1909	c.1802G>C	c.(1801-1803)GGT>GCT	p.G601A	GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Missense_Mutation_p.G532A	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	601					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CCTCTTTCTGGTCACAAGCTC	0.458													11	80					0	0	0	0	C	158402350	C	C	158402350	3	2	233	1	0	0	0	0	1	0	0	0	6378	1261	44	4	1860	4	GFM1	3	158402350	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	19324183	158402350	39620080	17	42149											
KIAA0226	9711	broad.mit.edu	37	chr3	197402348	197402348	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagatgatgtcatcctcattCtgacagaactcacagatgaa	15	10	7	9	0	4	6	3	3	1	3	5	6	5	6	1	0	1	0	1	0	3	1			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr3:197402348C>T	uc003fyc.2	-	19	2868	c.2685G>A	c.(2683-2685)CAG>CAA	p.Q895Q	KIAA0226_uc003fyd.3_Silent_p.Q850Q|MIR922_hsa-mir-922|MI0005714_5'Flank	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	895	Cys-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		CATCCTCATTCTGACAGAACT	0.547													21	188					0	0	0	0	T	197402348	T	T	197402348	2	4	233	1	0	0	0	0	0	0	0	1	8201	912	32	2		2	KIAA0226	3	197402348	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08	38999998	197402348	620082	18	42150											
NEK1	4750	broad.mit.edu	37	chr4	170523716	170523716	+	Frame_Shift_Del	DEL	T	-	-																															tgtctgccatcttctgtagaTttaacaagaatggcttttcc																										TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr4:170523716delT	uc003isb.1	-	2	558	c.66delA	c.(64-66)AAAfs	p.K22fs	NEK1_uc003isc.1_Frame_Shift_Del_p.K22fs|NEK1_uc003isd.1_Frame_Shift_Del_p.K22fs|NEK1_uc003ise.1_Frame_Shift_Del_p.K22fs|NEK1_uc003isf.1_Frame_Shift_Del_p.K22fs	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	22	Protein kinase.				cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		CTTCTGTAGATTTAACAAGAA	0.318													---	---	---								-	170523716	-	-	170523716	7	5	233	1	0	1	0	1	0	0	0	0	10375	1490	52	0	3842	0	NEK1	4	170523716	Frame_Shift_Del	DEL	T	TCGA-CV-7238-01A-11D-2012-08		170523716	20630560	19	42151											
SORBS2	8470	broad.mit.edu	37	chr4	186545502	186545502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccgggccatttgccagcCgttcttgaaactaatggctc	7	12	10	12	2	1	1	0	1	1	0	2	1	1	1	4	2	4	2	4	2	2	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr4:186545502C>T	uc003iyl.2	-	13	1927	c.1069G>A	c.(1069-1071)GGC>AGC	p.G357S	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.G457S|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.G261S|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.G471S|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	357						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		ATTTGCCAGCCGTTCTTGAAA	0.517													5	71					0	0	0	0	T	186545502	T	T	186545502	3	4	233	1	0	0	0	0	1	0	0	0	14992	652	23	1	2269	1	SORBS2	4	186545502	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	16021786	186545502	4608774	20	42152											
FYB	2533	broad.mit.edu	37	chr5	39134377	39134377	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atcttcaataggtcttgaagGggcaccaagagagtcttttt	11	13	10	7	0	4	2	1	1	3	1	4	3	4	2	1	3	0	1	1	3	4	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr5:39134377G>T	uc003jls.2	-	8	1817	c.1750C>A	c.(1750-1752)CCT>ACT	p.P584T	FYB_uc003jlt.2_Missense_Mutation_p.P584T|FYB_uc003jlu.2_Missense_Mutation_p.P584T|FYB_uc011cpl.1_Missense_Mutation_p.P594T	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	584					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding	p.P584L(1)		ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			GGTCTTGAAGGGGCACCAAGA	0.358													20	142					2.27731e-05	0.000337294	1	0	T	39134377	T	T	39134377	3	4	233	1	0	0	0	0	1	0	0	0	6158	1232	43	4	783	4	FYB	5	39134377	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08		39134377	141780883	21	42153											
SPATA9	83890	broad.mit.edu	37	chr5	95018550	95018550	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catatccacccaacaggtttGattggcatggtgagttcttg	9	13	10	9	0	1	2	0	2	1	0	2	2	2	2	2	3	1	3	2	3	2	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr5:95018550G>C	uc003klj.1	-	1	165	c.9C>G	c.(7-9)ATC>ATG	p.I3M	SPATA9_uc010jbh.1_RNA|SPATA9_uc003klh.1_RNA|SPATA9_uc003kli.1_RNA	NM_031952	NP_114158	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	3					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane					0		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		CAACAGGTTTGATTGGCATGG	0.463													7	60					0	0	0	0	C	95018550	C	C	95018550	3	2	233	1	0	0	0	0	1	0	0	0	15082	1280	45	2	775	2	SPATA9	5	95018550	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	55884173	95018550	85896710	22	42154											
C5orf30	90355	broad.mit.edu	37	chr5	102612013	102612013	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaggcgaaggcggatgccAagctcaggagacaagtgcac	13	3	16	9	2	1	1	1	0	0	1	1	5	1	3	1	5	3	2	1	5	3	0			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr5:102612013A>G	uc003kog.1	+	3	662	c.393A>G	c.(391-393)CCA>CCG	p.P131P	C5orf30_uc003koh.1_Silent_p.P131P	NM_033211	NP_149988	Q96GV9	CE030_HUMAN	hypothetical protein LOC90355	131											0		all_cancers(142;2.22e-05)|all_epithelial(76;9.54e-08)|Prostate(80;0.0174)|Colorectal(57;0.0551)|Ovarian(225;0.11)|Lung NSC(167;0.136)|all_lung(232;0.18)		Epithelial(69;2.84e-14)|COAD - Colon adenocarcinoma(37;0.00762)		GGCGGATGCCAAGCTCAGGAG	0.498													3	46					0	0	0	0	G	102612013	G	G	102612013	2	3	233	1	0	0	0	0	0	0	0	1	2300	117	5	5		5	C5orf30	5	102612013	Silent	SNP	A	TCGA-CV-7238-01A-11D-2012-08	7593463	102612013	78303247	23	42155											
FAT2	2196	broad.mit.edu	37	chr5	150924339	150924339	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccaagataggggtcaattcGgaaatatgtgtaatcttctg	12	12	10	7	1	3	1	1	0	2	1	4	2	3	2	1	3	0	1	1	3	6	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr5:150924339G>A	uc003lue.3	-	9	6362	c.6349C>T	c.(6349-6351)CGA>TGA	p.R2117*	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2117	Extracellular (Potential).|Cadherin 18.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGTCAATTCGGAAATATGTG	0.428													10	114					0	0	0	0	A	150924339	A	A	150924339	4	1	233	1	0	0	0	0	0	1	0	0	5722	1124	39	1	6760	1	FAT2	5	150924339	Nonsense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	48312326	150924339	29990921	24	42156											
STK10	6793	broad.mit.edu	37	chr5	171520515	171520515	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcagaggctgctgcagtcCgagtccctcttggaaggccc	6	8	14	13	1	1	1	0	0	1	1	3	3	3	2	3	3	3	4	3	3	1	1			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr5:171520515C>T	uc003mbo.1	-	9	1755	c.1455G>A	c.(1453-1455)TCG>TCA	p.S485S		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	485							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGCTGCAGTCCGAGTCCCTCT	0.607													13	134					0	0	0	0	T	171520515	T	T	171520515	2	4	233	1	0	0	0	0	0	0	0	1	15352	639	23	1		1	STK10	5	171520515	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08	20596176	171520515	9394745	25	42157											
KIAA0319	9856	broad.mit.edu	37	chr6	24596202	24596202	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcggcaagggaagcaacaCacttctctcagggagttttg	11	9	12	9	1	2	0	1	0	1	0	4	2	2	2	0	3	2	3	0	3	3	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr6:24596202C>G	uc011djo.1	-	3	937	c.700G>C	c.(700-702)GTG>CTG	p.V234L	KIAA0319_uc011djp.1_Missense_Mutation_p.V189L|KIAA0319_uc003neh.1_Missense_Mutation_p.V234L|KIAA0319_uc011djq.1_Missense_Mutation_p.V225L|KIAA0319_uc011djr.1_Missense_Mutation_p.V234L	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	234	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						GGAAGCAACACACTTCTCTCA	0.542													3	69					0	0	0	0	G	24596202	G	G	24596202	3	3	233	1	0	0	0	0	1	0	0	0	8207	478	17	4	2594	4	KIAA0319	6	24596202	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08		24596202	146518865	26	42158											
TNXB	7148	broad.mit.edu	37	chr6	32032668	32032668	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgtacaggttcatcttgtaCttgtggtctggctccaggcc	5	13	11	12	1	3	0	1	0	2	0	4	0	4	0	3	4	2	4	3	4	2	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr6:32032668C>T	uc003nzl.2	-	19	6973	c.6771G>A	c.(6769-6771)AAG>AAA	p.K2257K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2329	Fibronectin type-III 15.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCATCTTGTACTTGTGGTCTG	0.627													4	38					0	0	0	0	T	32032668	T	T	32032668	2	4	233	1	0	0	0	0	0	0	0	1	16412	564	20	4		4	TNXB	6	32032668	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08	7436466	32032668	139082399	27	42159											
PKHD1	5314	broad.mit.edu	37	chr6	51920457	51920457	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acaaggtgtcgaggctgacgGaggctgaacctgccacagaa	12	5	14	10	2	0	3	0	2	0	1	1	5	0	4	2	4	2	2	2	4	3	0			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr6:51920457G>A	uc003pah.1	-	19	2040	c.1764C>T	c.(1762-1764)CTC>CTT	p.L588L	PKHD1_uc003pai.2_Silent_p.L588L	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	588	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GAGGCTGACGGAGGCTGAACC	0.552													4	49					0	0	0	0	A	51920457	A	A	51920457	2	1	233	1	0	0	0	0	0	0	0	1	12026	1161	41	2		2	PKHD1	6	51920457	Silent	SNP	G	TCGA-CV-7238-01A-11D-2012-08	19887789	51920457	119194610	28	42160											
C6orf204	387119	broad.mit.edu	37	chr6	118812962	118812962	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcttttgctcaaattcccCttgttgggaatgggaaactg	10	13	10	8	0	1	0	1	0	0	0	2	2	2	2	2	2	3	3	2	2	4	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr6:118812962C>G	uc003pxz.1	-	6	1912	c.1324G>C	c.(1324-1326)GGG>CGG	p.G442R	C6orf204_uc003pya.1_Missense_Mutation_p.G445R|C6orf204_uc003pyb.2_Missense_Mutation_p.G442R|C6orf204_uc011ebj.1_Missense_Mutation_p.G340R|C6orf204_uc003pyc.2_Missense_Mutation_p.G445R	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	442	Potential.					centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		TCAAATTCCCCTTGTTGGGAA	0.373													4	47					0	0	0	0	G	118812962	G	G	118812962	3	3	233	1	0	0	0	0	1	0	0	0	2363	681	24	4	1179	4	C6orf204	6	118812962	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	66892505	118812962	52302105	29	42161											
LAMA2	3908	broad.mit.edu	37	chr6	129641784	129641784	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgattgtcccctgggctattCtggcctgtcctgtgaggtaa	5	14	12	10	0	1	2	0	2	1	0	3	2	3	2	4	3	0	2	4	3	2	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr6:129641784C>T	uc003qbn.2	+	28	4265	c.4160C>T	c.(4159-4161)TCT>TTT	p.S1387F	LAMA2_uc003qbo.2_Missense_Mutation_p.S1387F	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1387	Laminin EGF-like 14; second part.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTGGGCTATTCTGGCCTGTCC	0.443													4	31					0	0	0	0	T	129641784	T	T	129641784	3	4	233	1	0	0	0	0	1	0	0	0	8646	913	32	2	4270	2	LAMA2	6	129641784	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	10828822	129641784	41473283	30	42162											
BBS9	27241	broad.mit.edu	37	chr7	33185888	33185888	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctttatttaaagcccgtgaTtggtggtctactattctggg	7	17	10	7	1	3	1	0	1	3	0	3	1	3	1	1	3	2	0	1	3	5	8			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr7:33185888T>C	uc003tdn.1	+	2	537	c.24T>C	c.(22-24)GAT>GAC	p.D8D	BBS9_uc003tdo.1_Silent_p.D8D|BBS9_uc003tdp.1_Silent_p.D8D|BBS9_uc003tdq.1_Silent_p.D8D|BBS9_uc010kwn.1_RNA|BBS9_uc011kan.1_Silent_p.D8D	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	8					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			AAGCCCGTGATTGGTGGTCTA	0.323									Bardet-Biedl_syndrome				7	56					0	0	0	0	C	33185888	C	C	33185888	2	2	233	1	0	0	0	0	0	0	0	1	1344	1490	52	5		5	BBS9	7	33185888	Silent	SNP	T	TCGA-CV-7238-01A-11D-2012-08		33185888	125952775	31	42163											
ADCY1	107	broad.mit.edu	37	chr7	45717468	45717468	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatttccatgatggctccagCggagggcattaagaacagcc	11	9	11	10	1	0	2	0	1	0	1	2	3	2	3	3	3	3	2	3	3	3	3	rs143601874		TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr7:45717468C>T	uc003tne.3	+	9	1624	c.1606C>T	c.(1606-1608)CGG>TGG	p.R536W		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	536	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	ATGGCTCCAGCGGAGGGCATT	0.502													11	82					0	0	0	0	T	45717468	T	T	45717468	3	4	233	1	0	0	0	0	1	0	0	0	292	782	27	1	1640	1	ADCY1	7	45717468	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	12531580	45717468	113421195	32	42164											
PION	54103	broad.mit.edu	37	chr7	76940734	76940734	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcctctacaaattctgcatCcacattgtcatgtccttcaa	10	15	3	13	0	4	0	2	0	2	0	7	0	7	0	3	0	2	1	3	0	3	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr7:76940734C>T	uc003ugf.2	-	31	2585	c.2506G>A	c.(2506-2508)GAT>AAT	p.D836N	PION_uc011kgo.1_Missense_Mutation_p.D157N|PION_uc003ugd.2_Missense_Mutation_p.D230N	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	836					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						AATTCTGCATCCACATTGTCA	0.428													5	53					0	0	0	0	T	76940734	T	T	76940734	3	4	233	1	0	0	0	0	1	0	0	0	11989	855	30	2	62	2	PION	7	76940734	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	31223266	76940734	82197929	33	42165											
C7orf63	79846	broad.mit.edu	37	chr7	89915641	89915641	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctaatgaaaaggaagaagcCattgttttggaaatccagtc	15	10	9	7	0	0	2	0	1	0	1	2	4	1	4	3	2	1	1	3	2	6	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr7:89915641C>G	uc010lep.2	+	14	1835	c.1584C>G	c.(1582-1584)GCC>GCG	p.A528A	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_Silent_p.A203A|C7orf63_uc011khj.1_Silent_p.A510A|C7orf63_uc011khk.1_Silent_p.A90A	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	528							binding			ovary(1)	1						AGGAAGAAGCCATTGTTTTGG	0.318													5	52					0	0	0	0	G	89915641	G	G	89915641	2	3	233	1	0	0	0	0	0	0	0	1	2420	581	21	4		4	C7orf63	7	89915641	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08	12974907	89915641	69223022	34	42166											
SAMD9	54809	broad.mit.edu	37	chr7	92731813	92731813	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaaagcccaacttctatctCtccttgataaccagctatat	12	13	4	12	0	2	1	0	1	2	0	4	1	3	1	3	0	4	2	3	0	7	7			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr7:92731813C>T	uc003umf.2	-	3	3854	c.3598G>A	c.(3598-3600)GAG>AAG	p.E1200K	SAMD9_uc003umg.2_Missense_Mutation_p.E1200K	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1200						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			ACTTCTATCTCTCCTTGATAA	0.338													17	125					0	0	0	0	T	92731813	T	T	92731813	3	4	233	1	0	0	0	0	1	0	0	0	13891	922	32	2	1175	2	SAMD9	7	92731813	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	2816172	92731813	66406850	35	42167											
TAS2R40	259286	broad.mit.edu	37	chr7	142919246	142919246	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accttcactttggtggtctcCggaatagagtgcatcactgg	8	12	11	10	1	3	1	2	0	1	1	4	2	3	2	2	4	1	1	2	4	2	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr7:142919246C>T	uc011ksx.1	+	1	75	c.75C>T	c.(73-75)TCC>TCT	p.S25S		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	25	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					TGGTGGTCTCCGGAATAGAGT	0.517													11	80					0	0	0	0	T	142919246	T	T	142919246	2	4	233	1	0	0	0	0	0	0	0	1	15644	639	23	1		1	TAS2R40	7	142919246	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08	50187433	142919246	16219417	36	42168											
CSPP1	79848	broad.mit.edu	37	chr8	68007559	68007559	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagaaataaaaaacctattgGtcaagttaagcctgatctaa	18	10	7	6	0	2	2	1	1	1	1	2	3	2	2	2	1	2	1	2	1	8	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr8:68007559G>A	uc003xxi.2	+	8	678	c.647G>A	c.(646-648)GGT>GAT	p.G216D	CSPP1_uc003xxg.1_Missense_Mutation_p.G208D|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.G181D|CSPP1_uc003xxk.2_5'UTR	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	216						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAACCTATTGGTCAAGTTAAG	0.328													14	71					0	0	0	0	A	68007559	A	A	68007559	3	1	233	1	0	0	0	0	1	0	0	0	3979	1261	44	4	677	4	CSPP1	8	68007559	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08		68007559	78356463	37	42169											
TMEM70	54968	broad.mit.edu	37	chr8	74893475	74893475	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaaataatgctatttctgaAagtgtgcctctgcctattca	12	14	6	9	0	3	1	1	1	2	0	3	1	3	1	2	0	3	1	2	0	6	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr8:74893475A>C	uc003yab.2	+	3	489	c.402A>C	c.(400-402)GAA>GAC	p.E134D	TMEM70_uc003yac.2_3'UTR	NM_017866	NP_060336	Q9BUB7	TMM70_HUMAN	transmembrane protein 70 isoform a	134					mitochondrial proton-transporting ATP synthase complex assembly	integral to mitochondrial membrane|mitochondrial inner membrane				ovary(1)	1	Breast(64;0.0311)		Epithelial(68;0.0186)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0564)			CTATTTCTGAAAGTGTGCCTC	0.373													26	83					0	0	0	0	C	74893475	C	C	74893475	3	2	233	1	0	0	0	0	1	0	0	0	16265	11	1	5	420	5	TMEM70	8	74893475	Missense_Mutation	SNP	A	TCGA-CV-7238-01A-11D-2012-08	6885916	74893475	71470547	38	42170											
KCNQ3	3786	broad.mit.edu	37	chr8	133152401	133152401	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccatagcccctgtcttccGccatggggtcacctgtcccg	4	10	9	18	2	2	0	1	0	1	0	5	0	5	0	7	2	1	0	7	2	1	2			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr8:133152401G>A	uc003ytj.2	-	11	1715	c.1490C>T	c.(1489-1491)GCG>GTG	p.A497V	KCNQ3_uc010mdt.2_Missense_Mutation_p.A497V	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	497					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CCTGTCTTCCGCCATGGGGTC	0.612													13	31					0	0	0	0	A	133152401	A	A	133152401	3	1	233	1	0	0	0	0	1	0	0	0	8123	1087	38	1	1148	1	KCNQ3	8	133152401	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	58258926	133152401	13211621	39	42171											
DBC1	1620	broad.mit.edu	37	chr9	121929389	121929389	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttggctgtcatctggtcCgactgtttgaggatctccgt	5	15	12	9	2	3	1	1	1	2	0	5	3	4	2	2	3	0	3	2	3	0	2			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr9:121929389C>T	uc004bkc.2	-	8	2715	c.2259G>A	c.(2257-2259)TCG>TCA	p.S753S		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	753					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TCATCTGGTCCGACTGTTTGA	0.438													27	155					0	0	0	0	T	121929389	T	T	121929389	2	4	233	1	0	0	0	0	0	0	0	1	4264	639	23	1		1	DBC1	9	121929389	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08		121929389	19284042	40	42172											
NOTCH1	4851	broad.mit.edu	37	chr9	139407533	139407533	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcgtcaatacacgtgccctGgttcagacatgggttggacg	8	10	13	10	3	2	1	2	0	0	1	3	2	2	2	1	3	2	2	1	3	2	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr9:139407533G>A	uc004chz.2	-	15	2407	c.2407C>T	c.(2407-2409)CAG>TAG	p.Q803*	NOTCH1_uc004cia.1_Nonsense_Mutation_p.Q33*	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	803	Extracellular (Potential).|EGF-like 21; calcium-binding (Potential).			Q -> K (in Ref. 1; AAG33848 and 3; AAA60614).	aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CACGTGCCCTGGTTCAGACAT	0.637			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			11	36					0	0	0	0	A	139407533	A	A	139407533	4	1	233	1	0	0	0	0	0	1	0	0	10601	1357	47	4	5340	4	NOTCH1	9	139407533	Nonsense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	17478144	139407533	1805898	41	42173											
EHMT1	79813	broad.mit.edu	37	chr9	140611325	140611325	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcaaaaccacgtcactgcCgacgactttgtgcagacttc	12	8	8	13	3	1	1	1	0	0	1	2	3	1	1	2	0	4	2	2	0	3	2			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr9:140611325C>T	uc011mfc.1	+	3	370	c.333C>T	c.(331-333)GCC>GCT	p.A111A	EHMT1_uc004coa.2_Silent_p.A111A|EHMT1_uc004cob.1_Silent_p.A80A	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	111					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		ACGTCACTGCCGACGACTTTG	0.542													7	99					0	0	0	0	T	140611325	T	T	140611325	2	4	233	1	0	0	0	0	0	0	0	1	5005	639	23	1		1	EHMT1	9	140611325	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08	1203792	140611325	602106	42	42174											
IDI1	3422	broad.mit.edu	37	chr10	1087328	1087328	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctcattgggatctggattCaaagttacattcttcctcac	10	15	6	10	0	5	0	3	0	3	0	7	2	6	2	1	2	1	1	1	2	2	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr10:1087328C>G	uc001iga.2	-	5	772	c.654G>C	c.(652-654)TTG>TTC	p.L218F	C10orf110_uc010qaf.1_Intron|C10orf110_uc001ifx.3_Intron|C10orf110_uc001ifw.3_Intron|C10orf110_uc001ify.3_Intron|IDI1_uc001ifz.2_Missense_Mutation_p.L162F|IDI1_uc001igb.2_RNA|IDI1_uc001igc.2_Missense_Mutation_p.L162F	NM_004508	NP_004499	Q13907	IDI1_HUMAN	isopentenyl-diphosphate delta isomerase	161	Nudix hydrolase.				carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding				0		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.221)	Epithelial(11;0.0972)		GATCTGGATTCAAAGTTACAT	0.343													20	50					0	0	0	0	G	1087328	G	G	1087328	3	3	233	1	0	0	0	0	1	0	0	0	7538	825	29	2	204	2	IDI1	10	1087328	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08		1087328	134447419	43	42175											
C10orf71	118461	broad.mit.edu	37	chr10	50531131	50531131	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaaattcgctcctcttccaGaaaacagtgtcaacttctgc	11	11	5	14	1	3	1	1	0	2	1	6	1	5	1	3	0	3	1	3	0	4	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr10:50531131G>C	uc010qgp.1	+	3	880	c.541G>C	c.(541-543)GAA>CAA	p.E181Q		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	181											0						TCCTCTTCCAGAAAACAGTGT	0.532													11	28					0	0	0	0	C	50531131	C	C	50531131	3	2	233	1	0	0	0	0	1	0	0	0	1620	943	33	2	543	2	C10orf71	10	50531131	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	49443803	50531131	85003616	44	42176											
PTEN	5728	broad.mit.edu	37	chr10	89692805	89692805	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaagaccataacccaccaCagctagaacttatcaaaccc	16	7	4	14	0	1	3	1	1	0	2	1	3	1	3	4	0	4	1	4	0	6	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr10:89692805C>T	uc001kfb.2	+	6	1320	c.289C>T	c.(289-291)CAG>TAG	p.Q97*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	97	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.H93fs*5(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TAACCCACCACAGCTAGAACT	0.363		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			28	64					0	0	0	0	T	89692805	T	T	89692805	4	4	233	1	0	0	0	0	0	1	0	0	12800	479	17	4	307	4	PTEN	10	89692805	Nonsense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	39161674	89692805	45841942	45	42177											
APOA5	116519	broad.mit.edu	37	chr11	116661095	116661095	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggcggaaagcctgaagtcGctggcgcacctcctcggaga	8	6	14	13	4	0	2	0	1	0	1	3	4	1	3	3	4	1	2	3	4	2	0			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr11:116661095G>A	uc001ppr.2	-	3	858	c.850C>T	c.(850-852)CGA>TGA	p.R284*	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Nonsense_Mutation_p.R284*|APOA5_uc009yzf.2_Nonsense_Mutation_p.R284*|APOA5_uc009yzg.2_Nonsense_Mutation_p.R310*	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	284					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		GCCTGAAGTCGCTGGCGCACC	0.662													8	61					0	0	0	0	A	116661095	A	A	116661095	4	1	233	1	0	0	0	0	0	1	0	0	784	1095	38	1	254	1	APOA5	11	116661095	Nonsense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08		116661095	18345421	46	42178											
MLL	4297	broad.mit.edu	37	chr11	118375875	118375875	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgttaaccagaacatgcagCcactttatgttctccaaact	12	13	5	11	0	1	1	0	0	1	1	2	1	1	1	3	0	5	3	3	0	4	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr11:118375875C>T	uc001pta.2	+	27	9282	c.9259C>T	c.(9259-9261)CCA>TCA	p.P3087S	MLL_uc001ptb.2_Missense_Mutation_p.P3090S	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3087					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GAACATGCAGCCACTTTATGT	0.468			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								17	137					0	0	0	0	T	118375875	T	T	118375875	3	4	233	1	0	0	0	0	1	0	0	0	9673	739	26	4	9365	4	MLL	11	118375875	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	1714780	118375875	16630641	47	42179											
NCAPD3	23310	broad.mit.edu	37	chr11	134038398	134038398	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagattttggaagtgatgttGaatcgctgttcatctgtgaa	10	15	11	5	1	2	4	1	3	1	1	3	5	2	5	0	1	0	3	0	1	3	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr11:134038398G>A	uc001qhd.1	-	26	3945	c.3339C>T	c.(3337-3339)TTC>TTT	p.F1113F	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA|NCAPD3_uc001qhc.1_Silent_p.F63F	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1113					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		AAGTGATGTTGAATCGCTGTT	0.403													5	59					0	0	0	0	A	134038398	A	A	134038398	2	1	233	1	0	0	0	0	0	0	0	1	10260	1281	45	2		2	NCAPD3	11	134038398	Silent	SNP	G	TCGA-CV-7238-01A-11D-2012-08	15662523	134038398	968118	48	42180											
AVPR1A	552	broad.mit.edu	37	chr12	63541189	63541189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttggaagatttaggcgagtCcttccacatacccgtactgt	9	12	9	11	2	0	1	0	0	0	1	2	3	2	2	3	2	2	1	3	2	4	6			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr12:63541189C>T	uc001sro.1	-	2	3181	c.1207G>A	c.(1207-1209)GAC>AAC	p.D403N		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	403	Cytoplasmic (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	TTAGGCGAGTCCTTCCACATA	0.383													7	104					0	0	0	0	T	63541189	T	T	63541189	3	4	233	1	0	0	0	0	1	0	0	0	1233	855	30	2	53	2	AVPR1A	12	63541189	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08		63541189	70310706	49	42181											
NAV3	89795	broad.mit.edu	37	chr12	78224975	78224976	+	5'Flank	INS	-	AG	AG																															agagagagagagagagagacINSagagagagagagagagagag																								rs77759134	by1000genomes	TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	55adfb2c-fd21-4dd9-b934-203e8d99eebb	g.chr12:78224975_78224976insAG	uc001syp.2	+						NAV3_uc001syo.2_5'Flank	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3							nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						gagagagagacagagagagaga	0.208										HNSCC(70;0.22)			---	---	---								AG	78224976	AG	AG	78224975	6	5	233	0	1	1	1	0	0	0	0	0	10238	493	17	0		0	NAV3	12	78224975	5'Flank	INS	-	TCGA-CV-7238-01A-11D-2012-08	14683786	78224975	55626920	50	42182											
SETD8	387893	broad.mit.edu	37	chr12	123875278	123875278	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagagaactcagttacacaTcacgaagtcaaatgccaggg	16	6	10	9	1	3	1	3	0	0	1	3	4	3	1	1	1	3	1	1	1	5	1			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr12:123875278T>G	uc001uew.2	+	3	276	c.234T>G	c.(232-234)CAT>CAG	p.H78Q	SETD8_uc001uex.2_Missense_Mutation_p.H13Q	NM_020382	NP_065115	Q9NQR1	SETD8_HUMAN	SET domain-containing 8	119					cell division|mitosis|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding|transcription corepressor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.00101)|Epithelial(86;0.00425)		CAGTTACACATCACGAAGTCA	0.478													4	48					0	0	0	0	G	123875278	G	G	123875278	3	3	233	1	0	0	0	0	1	0	0	0	14202	1432	50	5	244	5	SETD8	12	123875278	Missense_Mutation	SNP	T	TCGA-CV-7238-01A-11D-2012-08	45650303	123875278	9976617	51	42183											
ATP11A	23250	broad.mit.edu	37	chr13	113479843	113479843	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggcagagtgagccctttcgGgatgagccgtggtataatca	9	10	14	8	2	1	3	1	2	0	1	2	4	1	4	2	3	2	2	2	3	2	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr13:113479843G>A	uc001vsi.3	+	11	1060	c.972G>A	c.(970-972)CGG>CGA	p.R324R	ATP11A_uc001vsj.3_Silent_p.R324R|ATP11A_uc001vsm.1_Silent_p.R200R	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	324	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				AGCCCTTTCGGGATGAGCCGT	0.488													11	43					0	0	0	0	A	113479843	A	A	113479843	2	1	233	1	0	0	0	0	0	0	0	1	1121	1219	43	4		4	ATP11A	13	113479843	Silent	SNP	G	TCGA-CV-7238-01A-11D-2012-08		113479843	1690035	52	42184											
FOXG1	2290	broad.mit.edu	37	chr14	29237514	29237514	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caccccatgccctacagctcCgtgttgactcagaactcgct	8	9	7	17	2	1	2	1	1	0	1	3	2	2	2	4	0	4	3	4	0	2	2			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr14:29237514C>T	uc001wqe.2	+	1	1228	c.1029C>T	c.(1027-1029)TCC>TCT	p.S343S		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	343					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CCTACAGCTCCGTGTTGACTC	0.652													18	125					0	0	0	0	T	29237514	T	T	29237514	2	4	233	1	0	0	0	0	0	0	0	1	6041	639	23	1		1	FOXG1	14	29237514	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08		29237514	78112026	53	42185											
FAM71D	161142	broad.mit.edu	37	chr14	67671543	67671543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgttcacagccatcctgaccCcgtacatgtatgcaggtaca	10	9	8	14	2	1	1	1	1	0	0	2	1	2	1	4	1	4	5	4	1	3	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr14:67671543C>T	uc001xja.1	+	5	903	c.649C>T	c.(649-651)CCG>TCG	p.P217S	FAM71D_uc010aqn.1_RNA	NM_173526	NP_775797	Q8N9W8	FA71D_HUMAN	hypothetical protein LOC161142	217										ovary(1)	1		all_hematologic(31;0.0116)		all cancers(60;0.00107)|BRCA - Breast invasive adenocarcinoma(234;0.00993)|OV - Ovarian serous cystadenocarcinoma(108;0.012)		CATCCTGACCCCGTACATGTA	0.498													5	113					0	0	0	0	T	67671543	T	T	67671543	3	4	233	1	0	0	0	0	1	0	0	0	5642	623	22	4	659	4	FAM71D	14	67671543	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	38434029	67671543	39677997	54	42186											
AP4E1	23431	broad.mit.edu	37	chr15	51223158	51223158	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactgggacttctaggaaaaGatgatcaaaggtaaactatt	16	11	9	5	0	2	2	1	1	1	1	2	4	2	4	0	3	2	1	0	3	8	6			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr15:51223158G>C	uc001zyx.1	+	7	889	c.859G>C	c.(859-861)GAT>CAT	p.D287H	AP4E1_uc010ufi.1_Missense_Mutation_p.D287H|AP4E1_uc010ufj.1_RNA|AP4E1_uc010ufk.1_RNA	NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	287					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		TCTAGGAAAAGATGATCAAAG	0.388													3	104					0	0	0	0	C	51223158	C	C	51223158	3	2	233	1	0	0	0	0	1	0	0	0	752	942	33	2	885	2	AP4E1	15	51223158	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08		51223158	51308234	55	42187											
HERC1	8925	broad.mit.edu	37	chr15	63978682	63978682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagctttctccgggtcaaagGatacttcttggataggaaga	11	11	12	7	1	3	1	1	0	2	1	4	5	3	4	1	4	2	1	1	4	4	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr15:63978682G>A	uc002amp.2	-	34	6249	c.6101C>T	c.(6100-6102)TCC>TTC	p.S2034F		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2034	B30.2/SPRY.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CGGGTCAAAGGATACTTCTTG	0.453													23	173					0	0	0	0	A	63978682	A	A	63978682	3	1	233	1	0	0	0	0	1	0	0	0	7096	1174	41	2	8664	2	HERC1	15	63978682	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	12755524	63978682	38552710	56	42188											
C15orf27	123591	broad.mit.edu	37	chr15	76449066	76449066	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtggtgattctcctgactCtggaacttctaatagatata	10	15	9	7	0	3	3	0	2	3	1	4	4	3	4	1	3	1	0	1	3	5	6			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr15:76449066C>G	uc002bbq.2	+	4	504	c.349C>G	c.(349-351)CTG>GTG	p.L117V	C15orf27_uc010bkp.2_Intron|C15orf27_uc002bbr.2_Intron	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	117	Helical; (Potential).					integral to membrane					0						TCTCCTGACTCTGGAACTTCT	0.423													4	43					0	0	0	0	G	76449066	G	G	76449066	3	3	233	1	0	0	0	0	1	0	0	0	1794	912	32	2	359	2	C15orf27	15	76449066	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	12470384	76449066	26082326	57	42189											
VWA3A	146177	broad.mit.edu	37	chr16	22161162	22161162	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcatggcaggacacgctggtGgagaccacagatgcagcgtg	10	6	15	10	2	1	2	1	0	0	2	1	4	1	3	1	4	2	3	1	4	0	0			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr16:22161162G>A	uc010vbq.1	+	29	3135	c.3039G>A	c.(3037-3039)GTG>GTA	p.V1013V	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_Silent_p.V91V|VWA3A_uc010bxe.1_Silent_p.V115V	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1013	VWFA 2.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		ACACGCTGGTGGAGACCACAG	0.557													5	14					0	0	0	0	A	22161162	A	A	22161162	2	1	233	1	0	0	0	0	0	0	0	1	17308	1335	47	4		4	VWA3A	16	22161162	Silent	SNP	G	TCGA-CV-7238-01A-11D-2012-08		22161162	68193591	58	42190											
ATP2C2	9914	broad.mit.edu	37	chr16	84492766	84492766	+	Frame_Shift_Del	DEL	A	-	-																															agggtattttttacaacatcAaaaactttgtccgattccag																										TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr16:84492766delA	uc002fhx.2	+	22	2277	c.2188delA	c.(2188-2190)AAAfs	p.K730fs	ATP2C2_uc010chj.2_Frame_Shift_Del_p.K730fs|ATP2C2_uc002fhy.2_Frame_Shift_Del_p.K747fs|ATP2C2_uc002fhz.2_Frame_Shift_Del_p.K579fs|ATP2C2_uc002fia.2_5'Flank	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	730	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						TTACAACATCAAAAACTTTGT	0.557													---	---	---								-	84492766	-	-	84492766	7	5	233	1	0	1	0	1	0	0	0	0	1146	131	5	0	2274	0	ATP2C2	16	84492766	Frame_Shift_Del	DEL	A	TCGA-CV-7238-01A-11D-2012-08	62331604	84492766	5861987	59	42191											
TP53	7157	broad.mit.edu	37	chr17	7578263	7578263	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgcaaatttccttccactcGgataagatgctgaggagggg	11	9	12	9	2	0	2	0	1	0	1	3	4	2	4	2	4	1	2	2	4	2	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr17:7578263G>A	uc002gim.2	-	6	780	c.586C>T	c.(586-588)CGA>TGA	p.R196*	TP53_uc002gig.1_Nonsense_Mutation_p.R196*|TP53_uc002gih.2_Nonsense_Mutation_p.R196*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R64*|TP53_uc010cng.1_Nonsense_Mutation_p.R64*|TP53_uc002gii.1_Nonsense_Mutation_p.R64*|TP53_uc010cnh.1_Nonsense_Mutation_p.R196*|TP53_uc010cni.1_Nonsense_Mutation_p.R196*|TP53_uc002gij.2_Nonsense_Mutation_p.R196*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R103*|TP53_uc002gio.2_Nonsense_Mutation_p.R64*|TP53_uc010vug.1_Nonsense_Mutation_p.R157*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(125)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.R196L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R64*(1)|p.I195fs*12(1)|p.R103*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	34					0	0	0	0	A	7578263	A	A	7578263	4	1	233	1	0	0	0	0	0	1	0	0	16448	1124	39	1	708	1	TP53	17	7578263	Nonsense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08		7578263	73616947	60	42192											
DNAH9	1770	broad.mit.edu	37	chr17	11757554	11757554	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcaggccgtatctgcaagacCccgagttcaatcctgagttt	9	11	9	12	2	3	2	2	1	1	1	4	3	4	2	4	1	1	4	4	1	3	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr17:11757554C>T	uc002gne.2	+	50	9810	c.9742C>T	c.(9742-9744)CCC>TCC	p.P3248S	DNAH9_uc010coo.2_Missense_Mutation_p.P2542S	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3248	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TCTGCAAGACCCCGAGTTCAA	0.488													13	157					0	0	0	0	T	11757554	T	T	11757554	3	4	233	1	0	0	0	0	1	0	0	0	4630	623	22	4	9940	4	DNAH9	17	11757554	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	4179291	11757554	69437656	61	42193											
SSH2	85464	broad.mit.edu	37	chr17	27958010	27958010	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtccctgggtctgtagcAcgggaaggcctccttcagaa	8	8	13	12	1	2	1	1	0	1	1	4	2	4	2	3	3	1	3	3	3	3	2			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr17:27958010A>T	uc002heo.1	-	15	4121	c.4121T>A	c.(4120-4122)GTG>GAG	p.V1374E	SSH2_uc010wbh.1_Missense_Mutation_p.V1401E	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	1374					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						GGTCTGTAGCACGGGAAGGCC	0.567													10	70					0	0	0	0	T	27958010	T	T	27958010	3	4	233	1	0	0	0	0	1	0	0	0	15251	159	6	5	154	5	SSH2	17	27958010	Missense_Mutation	SNP	A	TCGA-CV-7238-01A-11D-2012-08	16200456	27958010	53237200	62	42194											
BECN1	8678	broad.mit.edu	37	chr17	40968043	40968043	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catccagctccagctgctgtCgtttaaattcactgtattct	8	15	6	12	1	2	0	1	0	1	0	5	0	4	0	2	0	3	5	2	0	3	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr17:40968043C>T	uc002ibo.3	-	8	848	c.713G>A	c.(712-714)CGA>CAA	p.R238Q	BECN1_uc010whb.1_Missense_Mutation_p.R151Q|BECN1_uc010whc.1_Missense_Mutation_p.R162Q|BECN1_uc002ibn.2_Missense_Mutation_p.R238Q	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	238	Potential.				anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		CAGCTGCTGTCGTTTAAATTC	0.473													7	90					0	0	0	0	T	40968043	T	T	40968043	3	4	233	1	0	0	0	0	1	0	0	0	1398	884	31	1	659	1	BECN1	17	40968043	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	13010033	40968043	40227167	63	42195											
MAP3K14	9020	broad.mit.edu	37	chr17	43351864	43351864	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catgaagatgttgacccaagGcccttctctcacagctccat	10	10	7	14	0	2	3	1	2	1	1	4	3	3	3	3	1	1	2	3	1	2	2			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr17:43351864G>A	uc002iiw.1	-	8	1496	c.1387C>T	c.(1387-1389)CCT>TCT	p.P463S	MAP3K14_uc002iiu.1_5'Flank|MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_Missense_Mutation_p.P47S	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	463	Interaction with ZFP91.|Protein kinase.				cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						TTGACCCAAGGCCCTTCTCTC	0.547													5	29					0	0	0	0	A	43351864	A	A	43351864	3	1	233	1	0	0	0	0	1	0	0	0	9301	1203	42	4	1496	4	MAP3K14	17	43351864	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	2383821	43351864	37843346	64	42196											
SPATA20	64847	broad.mit.edu	37	chr17	48631733	48631733	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctattgaccgccttttcCgagcgcatgcgtcgtgtccc	4	12	10	15	5	0	1	0	1	0	0	3	2	2	1	5	0	3	1	5	0	1	4	rs147637130	byFrequency	TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr17:48631733C>T	uc002irf.2	+	14	2172	c.2031C>T	c.(2029-2031)TCC>TCT	p.S677S	SPATA20_uc002irc.2_Silent_p.S344S|SPATA20_uc002ire.2_Silent_p.S633S|SPATA20_uc002ird.2_Silent_p.S693S|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	677					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			CCGCCTTTTCCGAGCGCATGC	0.647													11	99					0	0	0	0	T	48631733	T	T	48631733	2	4	233	1	0	0	0	0	0	0	0	1	15072	639	23	1		1	SPATA20	17	48631733	Silent	SNP	C	TCGA-CV-7238-01A-11D-2012-08	5279869	48631733	32563477	65	42197											
MFSD11	79157	broad.mit.edu	37	chr17	74740437	74740437	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacagtgtttattgccctaaCggtgattagccttgtgggga	9	13	12	7	1	0	1	0	1	0	0	0	2	0	2	2	3	4	1	2	3	4	6			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr17:74740437C>T	uc002jta.2	+	8	1503	c.530C>T	c.(529-531)ACG>ATG	p.T177M	MFSD11_uc002jtb.2_Missense_Mutation_p.T177M|MFSD11_uc010dha.2_Missense_Mutation_p.T125M|MFSD11_uc002jtc.2_Missense_Mutation_p.T177M|MFSD11_uc002jtd.3_Missense_Mutation_p.T177M|MFSD11_uc010dhb.2_Missense_Mutation_p.T125M|MFSD11_uc002jte.2_Missense_Mutation_p.T177M	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	177	Helical; (Potential).					integral to membrane				ovary(1)	1						ATTGCCCTAACGGTGATTAGC	0.413													10	80					0	0	0	0	T	74740437	T	T	74740437	3	4	233	1	0	0	0	0	1	0	0	0	9582	536	19	1	556	1	MFSD11	17	74740437	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	26108704	74740437	6454773	66	42198											
ANKRD30B	374860	broad.mit.edu	37	chr18	14799113	14799113	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttagagtctcctgataaTgatggtcttctgaaggtaat	10	16	9	6	0	3	4	0	3	3	1	4	4	3	4	1	2	0	1	1	2	4	5			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr18:14799113T>A	uc010dlo.2	+	21	2223	c.2043T>A	c.(2041-2043)AAT>AAA	p.N681K	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(1)|skin(1)	2						CTCCTGATAATGATGGTCTTC	0.284													4	35					0	0	0	0	A	14799113	A	A	14799113	3	1	233	1	0	0	0	0	1	0	0	0	659	1461	51	5	2125	5	ANKRD30B	18	14799113	Missense_Mutation	SNP	T	TCGA-CV-7238-01A-11D-2012-08		14799113	63278135	67	42199											
KEAP1	9817	broad.mit.edu	37	chr19	10610205	10610205	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggaagtcactgcaggcacGgacaacgctgtcgatctggt	10	7	13	11	3	2	0	1	0	1	0	3	3	2	2	0	4	2	3	0	4	2	0			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr19:10610205G>A	uc002moq.1	-	2	661	c.505C>T	c.(505-507)CGT>TGT	p.R169C	KEAP1_uc002mor.1_Missense_Mutation_p.R169C	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CTGCAGGCACGGACAACGCTG	0.582													6	64					0	0	0	0	A	10610205	A	A	10610205	3	1	233	1	0	0	0	0	1	0	0	0	8180	1116	39	1	1389	1	KEAP1	19	10610205	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08		10610205	48518778	68	42200											
FXYD5	53827	broad.mit.edu	37	chr19	35660502	35660502	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagctgtcccggttatgccGgaatcgttgcaggtgagtcc	6	10	14	11	3	0	1	0	1	0	0	3	2	2	2	3	3	3	5	3	3	2	2			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr19:35660502G>T	uc002nyg.1	+	9	607	c.521G>T	c.(520-522)CGG>CTG	p.R174L	FXYD5_uc002nyh.1_Missense_Mutation_p.R174L|FXYD5_uc002nyi.1_Missense_Mutation_p.R111L|FXYD5_uc002nyj.1_RNA	NM_014164	NP_054883	Q96DB9	FXYD5_HUMAN	FXYD domain-containing ion transport regulator 5	174	Cytoplasmic (Potential).				microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity				0	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CGGTTATGCCGGAATCGTTGC	0.562													6	33					1.06961e-07	1.62022e-06	1	0	T	35660502	T	T	35660502	3	4	233	1	0	0	0	0	1	0	0	0	6155	1116	39	3	551	3	FXYD5	19	35660502	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	25050297	35660502	23468481	69	42201											
ZNF845	91664	broad.mit.edu	37	chr19	53855452	53855452	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagctttcagtttcaaatcAaaccttgaaagacataggat	16	11	7	7	0	3	2	3	1	0	1	3	4	3	3	1	1	2	2	1	1	5	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr19:53855452A>G	uc010ydv.1	+	4	1641	c.1524A>G	c.(1522-1524)TCA>TCG	p.S508S	ZNF845_uc010ydw.1_Silent_p.S508S	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	508	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTTTCAAATCAAACCTTGAAA	0.388													4	65					0	0	0	0	G	53855452	G	G	53855452	2	3	233	1	0	0	0	0	0	0	0	1	18258	117	5	5		5	ZNF845	19	53855452	Silent	SNP	A	TCGA-CV-7238-01A-11D-2012-08	18194950	53855452	5273531	70	42202											
LILRB2	10288	broad.mit.edu	37	chr19	54783667	54783667	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtcatcaccagcaccagggGgtcactgagctcagaccacc	10	6	10	15	0	4	2	4	1	0	1	4	2	4	2	4	2	2	2	4	2	0	0			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr19:54783667G>A	uc002qfb.2	-	4	600	c.334C>T	c.(334-336)CCC>TCC	p.P112S	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.P112S|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.P112S|LILRB2_uc010yet.1_5'UTR|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	112	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGCACCAGGGGGTCACTGAGC	0.607													5	76					0	0	0	0	A	54783667	A	A	54783667	3	1	233	1	0	0	0	0	1	0	0	0	8832	1232	43	4	1506	4	LILRB2	19	54783667	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	928215	54783667	4345316	71	42203											
SULF2	55959	broad.mit.edu	37	chr20	46291926	46291926	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcaccagtacgtgttattgTtggcgctggtgcaggcacag	7	11	14	9	2	0	0	0	0	0	0	0	0	0	0	1	3	3	7	1	3	2	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr20:46291926T>C	uc002xto.2	-	17	2588	c.2258A>G	c.(2257-2259)AAC>AGC	p.N753S	SULF2_uc002xtr.2_Missense_Mutation_p.N753S|SULF2_uc002xtq.2_Missense_Mutation_p.N753S|SULF2_uc010zyd.1_Missense_Mutation_p.N32S	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	753					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CGTGTTATTGTTGGCGCTGGT	0.517											OREG0026005	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	53					0	0	0	0	C	46291926	C	C	46291926	3	2	233	1	0	0	0	0	1	0	0	0	15437	1725	60	5	374	5	SULF2	20	46291926	Missense_Mutation	SNP	T	TCGA-CV-7238-01A-11D-2012-08		46291926	16733594	72	42204											
MRPL39	54148	broad.mit.edu	37	chr21	26961175	26961175	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatctttccaatagcttaTcccatattgtaaaatgtgcc	12	14	6	9	0	1	1	0	0	1	1	3	2	3	1	3	0	2	2	3	0	6	6			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr21:26961175T>C	uc002ylo.2	-	9	955	c.941A>G	c.(940-942)GAT>GGT	p.D314G	MRPL39_uc002yln.2_Missense_Mutation_p.D314G	NM_017446	NP_059142	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39 isoform a	314						mitochondrial ribosome	nucleotide binding				0						CAATAGCTTATCCCATATTGT	0.303													14	226					0	0	0	0	C	26961175	C	C	26961175	3	2	233	1	0	0	0	0	1	0	0	0	9855	1435	50	5	176	5	MRPL39	21	26961175	Missense_Mutation	SNP	T	TCGA-CV-7238-01A-11D-2012-08		26961175	21168720	73	42205											
C21orf29	54084	broad.mit.edu	37	chr21	45948404	45948404	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccggctggcatcaaaccagaActgggcgtcttccacctcgg	8	7	11	15	3	2	1	1	0	1	1	4	1	3	1	4	4	2	2	4	4	2	1			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chr21:45948404A>G	uc002zfe.1	-	6	919	c.853T>C	c.(853-855)TTC>CTC	p.F285L	C21orf29_uc010gpv.1_Missense_Mutation_p.F217L	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	285					cell adhesion	extracellular region	structural molecule activity				0						TCAAACCAGAACTGGGCGTCT	0.602													13	66					0	0	0	0	G	45948404	G	G	45948404	3	3	233	1	0	0	0	0	1	0	0	0	2134	43	2	5	1184	5	C21orf29	21	45948404	Missense_Mutation	SNP	A	TCGA-CV-7238-01A-11D-2012-08	18987229	45948404	2181491	74	42206											
DMD	1756	broad.mit.edu	37	chrX	32380923	32380923	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctttccagtcttaattctGtgtgaaatggctgcaaatcg	10	14	8	9	1	2	1	0	1	2	0	4	1	3	1	2	1	1	2	2	1	3	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chrX:32380923G>T	uc004dda.1	-	37	5551	c.5307C>A	c.(5305-5307)CAC>CAA	p.H1769Q	DMD_uc004dcw.2_Missense_Mutation_p.H425Q|DMD_uc004dcx.2_Missense_Mutation_p.H428Q|DMD_uc004dcz.2_Missense_Mutation_p.H1646Q|DMD_uc004dcy.1_Missense_Mutation_p.H1765Q|DMD_uc004ddb.1_Missense_Mutation_p.H1761Q|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1769	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTTAATTCTGTGTGAAATGG	0.473													14	140					3.32936e-07	4.98656e-06	1	0	T	32380923	T	T	32380923	3	4	233	1	0	0	0	0	1	0	0	0	4602	1368	48	4	6070	4	DMD	23	32380923	Missense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08		32380923	122889637	75	42207											
FAM123B	139285	broad.mit.edu	37	chrX	63410343	63410343	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagggaaaggggactgtctcGgctccattctccttcttcct	6	12	11	12	1	3	0	0	0	3	0	7	3	5	2	3	4	0	1	3	4	1	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chrX:63410343G>A	uc004dvo.2	-	2	3097	c.2824C>T	c.(2824-2826)CGA>TGA	p.R942*		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	942					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GGACTGTCTCGGCTCCATTCT	0.587													7	49					0	0	0	0	A	63410343	A	A	63410343	4	1	233	1	0	0	0	0	0	1	0	0	5451	1124	39	1	587	1	FAM123B	23	63410343	Nonsense_Mutation	SNP	G	TCGA-CV-7238-01A-11D-2012-08	31029420	63410343	91860217	76	42208											
KIF4A	24137	broad.mit.edu	37	chrX	69510347	69510347	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaattcccgtaagagtggcGctgcgttgtcgccctctggt	5	11	14	11	4	1	1	0	0	1	1	3	2	2	2	2	3	1	3	2	3	2	3			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chrX:69510347G>A	uc004dyg.2	+	2	166	c.39G>A	c.(37-39)GCG>GCA	p.A13A	KIF4A_uc010nkw.2_Silent_p.A13A|PDZD11_uc004dyd.1_5'Flank|PDZD11_uc004dye.1_5'Flank|KIF4A_uc004dyf.1_Silent_p.A13A	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	13	Kinesin-motor.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						TAAGAGTGGCGCTGCGTTGTC	0.557													9	50					0	0	0	0	A	69510347	A	A	69510347	2	1	233	1	0	0	0	0	0	0	0	1	8342	1074	38	1		1	KIF4A	23	69510347	Silent	SNP	G	TCGA-CV-7238-01A-11D-2012-08	6100004	69510347	85760213	77	42209											
RLIM	51132	broad.mit.edu	37	chrX	73812879	73812879	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagtcaccattagacacatCatctgaagagtctcctcctg	12	10	7	12	0	4	4	2	1	2	3	6	4	5	4	3	0	0	0	3	0	2	1			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chrX:73812879C>T	uc004ebu.2	-	5	561	c.271G>A	c.(271-273)GAT>AAT	p.D91N	RLIM_uc004ebw.2_Missense_Mutation_p.D91N	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	91					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TTAGACACATCATCTGAAGAG	0.418													7	70					0	0	0	0	T	73812879	T	T	73812879	3	4	233	1	0	0	0	0	1	0	0	0	13455	826	29	2	1607	2	RLIM	23	73812879	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	4302532	73812879	81457681	78	42210											
SRPX2	27286	broad.mit.edu	37	chrX	99925827	99925827	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atttcagcgcctcactcgctCctacttcaacatggtgttga	8	13	7	13	2	3	1	3	1	0	0	5	1	4	1	2	1	3	2	2	1	2	4			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chrX:99925827C>G	uc004egb.2	+	11	1721	c.1241C>G	c.(1240-1242)TCC>TGC	p.S414C		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	414					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						CTCACTCGCTCCTACTTCAAC	0.517											OREG0019890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	101					0	0	0	0	G	99925827	G	G	99925827	3	3	233	1	0	0	0	0	1	0	0	0	15231	855	30	2	1279	2	SRPX2	23	99925827	Missense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	26112948	99925827	55344733	79	42211											
ARHGEF6	9459	broad.mit.edu	37	chrX	135754234	135754234	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcaatgatgagtttctCttcctcagggagtaggactt	8	16	9	8	0	4	2	2	2	2	0	6	4	5	4	1	2	0	2	1	2	2	6			TCGA-CV-7238-01A-11D-2012-08	TCGA-CV-7238-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9619e49-7185-4158-9e8b-45d446960b60	89cd05d8-c8df-41e1-8df6-5d108fabd7f6	g.chrX:135754234C>A	uc004fab.2	-	20	2542	c.2080G>T	c.(2080-2082)GAG>TAG	p.E694*	ARHGEF6_uc011mwd.1_Nonsense_Mutation_p.E567*|ARHGEF6_uc011mwe.1_Nonsense_Mutation_p.E540*	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	694					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					ATGAGTTTCTCTTCCTCAGGG	0.473													13	159					0.000219431	0.00317937	1	0	A	135754234	A	A	135754234	4	1	233	1	0	0	0	0	0	1	0	0	910	922	32	2	262	2	ARHGEF6	23	135754234	Nonsense_Mutation	SNP	C	TCGA-CV-7238-01A-11D-2012-08	35828407	135754234	19516326	80	42212											
ACTRT2	140625	broad.mit.edu	37	chr1	2939112	2939112	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagcagcatcaccaagtgtGataccgacatccagaagatc	14	6	8	13	1	1	3	1	1	0	2	3	4	2	3	4	0	3	2	4	0	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:2939112G>A	uc001ajz.2	+	1	1067	c.862G>A	c.(862-864)GAT>AAT	p.D288N		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	288						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		CACCAAGTGTGATACCGACAT	0.632													29	98					0	0	0	0	A	2939112	A	A	2939112	3	1	234	1	0	0	0	0	1	0	0	0	219	1290	45	2	864	2	ACTRT2	1	2939112	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08		2939112	246311509	1	42213											
CAMTA1	23261	broad.mit.edu	37	chr1	7737775	7737775	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctcccttcctcccagcacGactggctgtcgttggacggt	4	10	11	16	4	0	0	0	0	0	0	4	2	3	1	3	3	1	4	3	3	0	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:7737775G>T	uc001aoi.2	+	11	3103	c.2896G>T	c.(2896-2898)GAC>TAC	p.D966Y	CAMTA1_uc010nzv.1_Missense_Mutation_p.D53Y|CAMTA1_uc001aok.3_5'Flank	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	966					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CTCCCAGCACGACTGGCTGTC	0.557													21	52					2.32416e-17	5.83036e-17	1	0	T	7737775	T	T	7737775	3	4	234	1	0	0	0	0	1	0	0	0	2625	1058	37	3	2938	3	CAMTA1	1	7737775	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	4798663	7737775	241512846	2	42214											
PRAMEF2	65122	broad.mit.edu	37	chr1	12921146	12921146	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaagaggacttgaagtgtCtctcccagttcccaagcctc	10	10	9	12	0	1	3	0	1	1	2	5	4	3	4	3	1	1	1	3	1	4	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:12921146C>A	uc001aum.1	+	4	1024	c.937C>A	c.(937-939)CTC>ATC	p.L313I		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	313											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTTGAAGTGTCTCTCCCAGTT	0.493													42	175					2.47872e-24	6.55605e-24	1	0	A	12921146	A	A	12921146	3	1	234	1	0	0	0	0	1	0	0	0	12495	913	32	2	947	2	PRAMEF2	1	12921146	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	5183371	12921146	236329475	3	42215											
C1orf63	57035	broad.mit.edu	37	chr1	25573429	25573429	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcctgcggcgagcccggcCacatgtcgttcacgtagttg	5	10	12	14	5	2	0	1	0	1	0	4	1	2	0	3	2	2	3	3	2	1	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:25573429C>A	uc001bjw.2	-	2	278	c.26G>T	c.(25-27)TGG>TTG	p.W9L		NM_020317	NP_064713	Q9BUV0	CA063_HUMAN	hypothetical protein LOC57035	9										pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.9e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000333)|BRCA - Breast invasive adenocarcinoma(304;0.000443)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000932)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CGAGCCCGGCCACATGTCGTT	0.607													22	89					8.24728e-16	2.03396e-15	1	0	A	25573429	A	A	25573429	3	1	234	1	0	0	0	0	1	0	0	0	2063	595	21	4	862	4	C1orf63	1	25573429	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	12652283	25573429	223677192	4	42216											
MPL	4352	broad.mit.edu	37	chr1	43803901	43803901	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgctgtatgcctacccgCggtaggtgctggactgtgcc	5	10	14	12	2	0	0	0	0	0	0	0	1	0	1	3	3	6	5	3	3	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:43803901C>A	uc001ciw.2	+	2	256	c.211C>A	c.(211-213)CGG>AGG	p.R71R	MPL_uc001civ.2_Silent_p.R71R|MPL_uc009vwr.2_Silent_p.R64R	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	71	Extracellular (Potential).				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity	p.R71W(1)		haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGCCTACCCGCGGTAGGTGCT	0.577			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						7	36					0.00448238	0.00832605	1	0	A	43803901	A	A	43803901	2	1	234	1	0	0	0	0	0	0	0	1	9783	782	27	3		3	MPL	1	43803901	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	18230472	43803901	205446720	5	42217											
KIAA0467	23334	broad.mit.edu	37	chr1	43903291	43903291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagagacatcctgcagtgacCggccatggaaaggggatgcg	11	6	15	9	2	0	2	0	1	0	1	1	5	1	4	3	4	2	1	3	4	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:43903291C>T	uc001cjk.1	+	30	4081	c.3619C>T	c.(3619-3621)CGG>TGG	p.R1207W		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2106						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGCAGTGACCGGCCATGGAA	0.577													13	41					0	0	0	0	T	43903291	T	T	43903291	3	4	234	1	0	0	0	0	1	0	0	0	8217	643	23	1	3729	1	KIAA0467	1	43903291	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	99390	43903291	205347330	6	42218											
RNF11	26994	broad.mit.edu	37	chr1	51735628	51735628	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tctatattttaatattttagGaacaagttccagttccagtc	12	17	5	7	0	1	0	0	0	1	0	4	1	3	1	2	1	1	2	2	1	7	9			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:51735628G>C	uc001csi.3	+	2	608	c.124G>C	c.(124-126)GAA>CAA	p.E42Q		NM_014372	NP_055187	Q9Y3C5	RNF11_HUMAN	ring finger protein 11	42					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	DNA binding|protein binding|zinc ion binding				0						AATATTTTAGGAACAAGTTCC	0.413													7	33					0	0	0	0	C	51735628	C	C	51735628	3	2	234	1	0	0	0	0	1	0	0	0	13489	1188	41	2	130	2	RNF11	1	51735628	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	7832337	51735628	197514993	7	42219											
TMEM61	199964	broad.mit.edu	37	chr1	55451924	55451924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccccacccacggagtatcCggtgcctgagggccccagcc	6	4	13	18	2	0	1	0	1	0	0	1	2	1	2	8	4	2	1	8	4	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:55451924C>T	uc001cyd.2	+	2	444	c.170C>T	c.(169-171)CCG>CTG	p.P57L		NM_182532	NP_872338	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	57						integral to membrane					0						ACGGAGTATCCGGTGCCTGAG	0.682													27	79					0	0	0	0	T	55451924	T	T	55451924	3	4	234	1	0	0	0	0	1	0	0	0	16254	652	23	1	176	1	TMEM61	1	55451924	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	3716296	55451924	193798697	8	42220											
GBP1	2633	broad.mit.edu	37	chr1	89523674	89523674	+	Splice_Site	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtactaggaaggggacttaCgaggcccgttgacctggatg	10	8	15	8	2	0	1	0	1	0	0	0	5	0	4	2	5	2	2	2	5	4	4	rs139189718	byFrequency	TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:89523674C>A	uc001dmx.2	-	6	1094	c.874_splice	c.e6+1	p.R292_splice		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,						interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		AGGGGACTTACGAGGCCCGTT	0.423													28	63					3.65163e-15	8.91535e-15	1	0	A	89523674	A	A	89523674	5	1	234	1	0	0	0	0	0	0	1	0	6308	550	19	3	927	3	GBP1	1	89523674	Splice_Site	SNP	C	TCGA-CV-7242-01A-11D-2012-08	34071750	89523674	159726947	9	42221											
DBT	1629	broad.mit.edu	37	chr1	100701061	100701061	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaactgaacaacctgtccaCggagagcttcaaagacaaat	16	7	8	10	1	1	4	1	2	0	2	2	5	2	4	2	1	4	1	2	1	5	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:100701061C>A	uc001dta.2	-	3	215	c.182G>T	c.(181-183)CGT>CTT	p.R61L	DBT_uc010oug.1_5'UTR	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	61					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		AACCTGTCCACGGAGAGCTTC	0.333													9	22					5.4927e-09	1.17932e-08	1	0	A	100701061	A	A	100701061	3	1	234	1	0	0	0	0	1	0	0	0	4275	536	19	3	1302	3	DBT	1	100701061	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	11177387	100701061	148549560	10	42222											
WDR77	79084	broad.mit.edu	37	chr1	111991351	111991351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttcgttgggggcggcacagGggtccttaaaaagccagagg	9	7	16	9	2	0	1	0	0	0	1	2	1	1	1	2	6	1	2	2	6	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:111991351G>A	uc001ebb.2	-	2	230	c.191C>T	c.(190-192)CCC>CTC	p.P64L	WDR77_uc010owd.1_RNA|WDR77_uc010owe.1_Missense_Mutation_p.P64L|ATP5F1_uc009wgf.1_5'Flank|ATP5F1_uc001ebc.2_5'Flank|ATP5F1_uc001ebd.3_5'Flank	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	64					ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		GGCGGCACAGGGGTCCTTAAA	0.652													3	11					0	0	0	0	A	111991351	A	A	111991351	3	1	234	1	0	0	0	0	1	0	0	0	17395	1232	43	4	873	4	WDR77	1	111991351	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	11290290	111991351	137259270	11	42223											
PDE4DIP	9659	broad.mit.edu	37	chr1	145039590	145039590	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggaaacagcccacctacCtcgtccaggtctgctccatt	10	8	8	15	1	1	0	0	0	1	0	4	2	3	1	5	2	4	1	5	2	3	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:145039590C>G	uc001elx.3	-	1	355	c.20G>C	c.(19-21)AGA>ACA	p.R7T	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elm.3_5'UTR|PDE4DIP_uc001eln.3_Missense_Mutation_p.R7T|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001emh.2_Intron	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:Variant_position_missing_in_Q5VU43_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCCCACCTACCTCGTCCAGGT	0.627			T	PDGFRB	MPD								3	53					0	0	0	0	G	145039590	G	G	145039590	3	3	234	1	0	0	0	0	1	0	0	0	11697	696	24	4		4	PDE4DIP	1	145039590	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	33048239	145039590	104211031	12	42224											
TUFT1	7286	broad.mit.edu	37	chr1	151553494	151553494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caacttcagcacccaggcccGggccaagacagagaacccgg	12	2	11	16	2	1	2	1	0	0	2	1	3	1	2	4	3	3	1	4	3	3	1	rs150712835		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:151553494G>A	uc001eyl.2	+	12	1147	c.1085G>A	c.(1084-1086)CGG>CAG	p.R362Q	TUFT1_uc001eym.2_Missense_Mutation_p.R337Q|TUFT1_uc010pdf.1_Missense_Mutation_p.R381Q|TUFT1_uc010pdg.1_Missense_Mutation_p.R310Q	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1	362					bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACCCAGGCCCGGGCCAAGACA	0.522													16	48					0	0	0	0	A	151553494	A	A	151553494	3	1	234	1	0	0	0	0	1	0	0	0	16840	1116	39	1	1131	1	TUFT1	1	151553494	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	6513904	151553494	97697127	13	42225											
FCRL5	83416	broad.mit.edu	37	chr1	157514694	157514694	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatccagtacagcgatatgcAccattgtccttgagacatgc	11	11	8	11	1	0	1	0	1	0	1	2	3	2	1	3	0	4	2	3	0	3	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:157514694A>C	uc001fqu.2	-	4	644	c.486T>G	c.(484-486)GGT>GGG	p.G162G	FCRL5_uc009wsm.2_Silent_p.G162G|FCRL5_uc010phv.1_Silent_p.G162G|FCRL5_uc010phw.1_Silent_p.G77G|FCRL5_uc001fqv.1_Silent_p.G162G|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	162	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AGCGATATGCACCATTGTCCT	0.363													13	98					0	0	0	0	C	157514694	C	C	157514694	2	2	234	1	0	0	0	0	0	0	0	1	5830	146	6	5		5	FCRL5	1	157514694	Silent	SNP	A	TCGA-CV-7242-01A-11D-2012-08	5961200	157514694	91735927	14	42226											
ILDR2	387597	broad.mit.edu	37	chr1	166904662	166904662	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggagtaagggccggggacAccggagacagagggagggta	12	3	20	6	2	0	2	0	0	0	2	0	6	0	5	2	7	0	2	2	7	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:166904662A>T	uc001gdx.1	-	6	812	c.756T>A	c.(754-756)GGT>GGA	p.G252G		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	252	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						GGCCGGGGACACCGGAGACAG	0.602													15	39					0	0	0	0	T	166904662	T	T	166904662	2	4	234	1	0	0	0	0	0	0	0	1	7749	146	6	5		5	ILDR2	1	166904662	Silent	SNP	A	TCGA-CV-7242-01A-11D-2012-08	9389968	166904662	82345959	15	42227											
MAEL	84944	broad.mit.edu	37	chr1	166961962	166961962	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttattttttgaacatttttaGccatggcgagctacctcctc	8	17	6	10	1	0	1	0	1	0	0	2	2	1	1	3	1	4	1	3	1	4	8			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:166961962G>T	uc001gdy.1	+	4	436	c.365G>T	c.(364-366)AGC>ATC	p.S122I	MAEL_uc001gdz.1_Missense_Mutation_p.S91I|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	122					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						AACATTTTTAGCCATGGCGAG	0.363													34	35					3.62531e-18	9.12577e-18	1	0	T	166961962	T	T	166961962	3	4	234	1	0	0	0	0	1	0	0	0	9205	971	34	4	379	4	MAEL	1	166961962	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	57300	166961962	82288659	16	42228											
DUSP27	92235	broad.mit.edu	37	chr1	167097477	167097477	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caagttcccgagaggagagcCcagagccctacttcttccgc	9	7	10	15	2	1	3	0	0	1	3	3	5	3	3	4	1	3	1	4	1	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:167097477C>T	uc001geb.1	+	5	3109	c.3109C>T	c.(3109-3111)CCA>TCA	p.P1037S		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1037					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						AGAGGAGAGCCCAGAGCCCTA	0.587													19	23					0	0	0	0	T	167097477	T	T	167097477	3	4	234	1	0	0	0	0	1	0	0	0	4846	623	22	4	3127	4	DUSP27	1	167097477	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	135515	167097477	82153144	17	42229											
PRRX1	5396	broad.mit.edu	37	chr1	170633230	170633231	+	5'Flank	DEL	CT	-	-																															ccttccctccctcttcctccCtctctctctctctctctcca																								rs72437070		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	f50dc054-f0b0-4b11-be76-09ae612abc8e	g.chr1:170633230_170633231delCT	uc001ghf.2	+						PRRX1_uc001ghe.2_5'Flank	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ctcttcctccctctctctctct	0.46													---	---	---								-	170633231	-	-	170633230	6	5	234	0	1	1	0	1	0	0	0	0	12674	696	24	0		0	PRRX1	1	170633230	5'Flank	DEL	CT	TCGA-CV-7242-01A-11D-2012-08	3535753	170633230	78617391	18	42230											
TNR	7143	broad.mit.edu	37	chr1	175325503	175325503	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actggtgagaggtccattggTggcatacatggtggcagtat	9	11	15	6	0	0	1	0	1	0	1	1	2	1	1	1	6	1	3	1	6	2	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:175325503T>C	uc001gkp.1	-	14	3151	c.3070A>G	c.(3070-3072)ACC>GCC	p.T1024A	TNR_uc009wwu.1_Missense_Mutation_p.T1024A	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1024	Fibronectin type-III 8.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GGTCCATTGGTGGCATACATG	0.507													11	75					0	0	0	0	C	175325503	C	C	175325503	3	2	234	1	0	0	0	0	1	0	0	0	16404	1696	59	5	1038	5	TNR	1	175325503	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	4692273	175325503	73925118	19	42231											
PAPPA2	60676	broad.mit.edu	37	chr1	176640251	176640251	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggacgctgtcactcacctgGgtaagtgaaatgaagaccaa	14	7	11	9	1	2	3	2	2	0	1	2	4	2	4	2	2	0	2	2	2	4	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:176640251G>A	uc001gkz.2	+	4	3301	c.2137G>A	c.(2137-2139)GGT>AGT	p.G713S	PAPPA2_uc001gky.1_Missense_Mutation_p.G713S|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	713	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CACTCACCTGGGTAAGTGAAA	0.433													27	71					0	0	0	0	A	176640251	A	A	176640251	3	1	234	1	0	0	0	0	1	0	0	0	11487	1246	43	4	2147	4	PAPPA2	1	176640251	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	1314748	176640251	72610370	20	42232											
KIAA1614	57710	broad.mit.edu	37	chr1	180885313	180885313	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcccaagacagggagtggaaCagccagccccgtggagggga	11	2	17	11	1	0	1	0	0	0	1	0	5	0	5	4	5	3	0	4	5	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:180885313C>G	uc001gok.2	+	2	141	c.74C>G	c.(73-75)ACA>AGA	p.T25R		NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	25										ovary(3)|skin(1)	4						GGGAGTGGAACAGCCAGCCCC	0.617													3	41					0	0	0	0	G	180885313	G	G	180885313	3	3	234	1	0	0	0	0	1	0	0	0	8287	478	17	4	80	4	KIAA1614	1	180885313	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	4245062	180885313	68365308	21	42233											
CFH	3075	broad.mit.edu	37	chr1	196712681	196712681	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagagtacgttatcaatgtaGgagcccttatgaaatgtttg	12	13	11	5	1	1	2	1	1	0	1	1	4	1	3	1	1	2	4	1	1	6	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:196712681G>T	uc001gtj.3	+	20	3473	c.3233G>T	c.(3232-3234)AGG>ATG	p.R1078M		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1078	Sushi 18.		R -> S (associated with basal laminar drusen).		complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TATCAATGTAGGAGCCCTTAT	0.398													19	72					2.94398e-08	6.26562e-08	1	0	T	196712681	T	T	196712681	3	4	234	1	0	0	0	0	1	0	0	0	3298	1000	35	4	3329	4	CFH	1	196712681	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	15827368	196712681	52537940	22	42234											
CRB1	23418	broad.mit.edu	37	chr1	197396759	197396759	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatatccgtgtctggctagaGcgcggcagactagcaatgct	9	10	12	10	3	1	2	0	0	1	2	2	2	2	2	1	2	3	4	1	2	5	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:197396759G>A	uc001gtz.2	+	7	2439	c.2304G>A	c.(2302-2304)GAG>GAA	p.E768E	CRB1_uc010poz.1_Silent_p.E699E|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.E656E|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Silent_p.E249E|CRB1_uc001gub.1_Silent_p.E417E	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	768	Extracellular (Potential).|Laminin G-like 2.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TCTGGCTAGAGCGCGGCAGAC	0.418													20	19					0	0	0	0	A	197396759	A	A	197396759	2	1	234	1	0	0	0	0	0	0	0	1	3863	962	34	4		4	CRB1	1	197396759	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	684078	197396759	51853862	23	42235											
OPTC	26254	broad.mit.edu	37	chr1	203472812	203472812	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcttccccagcgcctacttCtgcctgcctcggctccccat	3	11	6	21	2	2	0	0	0	2	0	5	0	4	0	7	1	4	1	7	1	1	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:203472812C>T	uc001gzu.1	+	7	1079	c.963C>T	c.(961-963)TTC>TTT	p.F321F		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	321						proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCGCCTACTTCTGCCTGCCTC	0.632													31	62					0	0	0	0	T	203472812	T	T	203472812	2	4	234	1	0	0	0	0	0	0	0	1	10942	912	32	2		2	OPTC	1	203472812	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	6076053	203472812	45777809	24	42236											
PROX1	5629	broad.mit.edu	37	chr1	214171294	214171294	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtcgcctctctctgccacCacgggcttcaccacgtccac	6	8	7	20	3	3	0	1	0	2	0	6	0	4	0	5	1	1	1	5	1	0	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:214171294C>A	uc001hkh.2	+	2	1688	c.1416C>A	c.(1414-1416)ACC>ACA	p.T472T	PROX1_uc001hkg.1_Silent_p.T472T	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	472					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TCTCTGCCACCACGGGCTTCA	0.647													59	65					9.77497e-20	2.51258e-19	1	0	A	214171294	A	A	214171294	2	1	234	1	0	0	0	0	0	0	0	1	12622	581	21	4		4	PROX1	1	214171294	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	10698482	214171294	35079327	25	42237											
USH2A	7399	broad.mit.edu	37	chr1	216591996	216591996	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtttgaacacaatctgccCatctactgtcttttctataa	12	15	4	10	0	4	1	0	1	4	0	4	1	4	1	1	0	3	1	1	0	6	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:216591996C>T	uc001hku.1	-	3	898	c.511G>A	c.(511-513)GGG>AGG	p.G171R	USH2A_uc001hkv.2_Missense_Mutation_p.G171R	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	171	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAATCTGCCCATCTACTGTC	0.388										HNSCC(13;0.011)			7	57					0	0	0	0	T	216591996	T	T	216591996	3	4	234	1	0	0	0	0	1	0	0	0	17104	594	21	4	15391	4	USH2A	1	216591996	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	2420702	216591996	32658625	26	42238											
CEP170	9859	broad.mit.edu	37	chr1	243362455	243362455	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atcatccccccaccatgacgGctgcccatataatggagtac	11	8	7	15	1	1	1	1	1	0	0	2	2	2	2	5	2	2	2	5	2	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:243362455G>C	uc001hzs.2	-	7	946	c.538C>G	c.(538-540)CCG>GCG	p.P180A	CEP170_uc001hzt.2_Missense_Mutation_p.P180A|CEP170_uc001hzu.2_Missense_Mutation_p.P180A	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	180						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CACCATGACGGCTGCCCATAT	0.418													12	16					0	0	0	0	C	243362455	C	C	243362455	3	2	234	1	0	0	0	0	1	0	0	0	3265	1203	42	4	4302	4	CEP170	1	243362455	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	26770459	243362455	5888166	27	42239											
OR2T1	26696	broad.mit.edu	37	chr1	248569884	248569884	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgttggatgattatagcaGgttcctggtttgggggctct	5	16	14	6	0	2	1	0	1	2	0	3	2	3	2	1	5	1	5	1	5	2	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr1:248569884G>T	uc010pzm.1	+	1	589	c.589G>T	c.(589-591)GGT>TGT	p.G197C		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	197	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATTATAGCAGGTTCCTGGTT	0.542													49	49					8.04919e-23	2.09854e-22	1	0	T	248569884	T	T	248569884	3	4	234	1	0	0	0	0	1	0	0	0	11070	1000	35	4	591	4	OR2T1	1	248569884	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	5207429	248569884	680737	28	42240											
MYT1L	23040	broad.mit.edu	37	chr2	1796146	1796146	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcagagactggctcaggtTcgccagctcgtggaggagag	9	7	16	9	2	2	2	2	0	0	2	4	6	2	3	1	4	1	3	1	4	0	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:1796146T>C	uc002qxe.2	-	24	4194	c.3367A>G	c.(3367-3369)AAC>GAC	p.N1123D	MYT1L_uc002qxd.2_Missense_Mutation_p.N1121D|MYT1L_uc010ewk.2_Missense_Mutation_p.N121D	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1123	Potential.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TGGCTCAGGTTCGCCAGCTCG	0.547													5	12					0	0	0	0	C	1796146	C	C	1796146	3	2	234	1	0	0	0	0	1	0	0	0	10160	1783	62	5	201	5	MYT1L	2	1796146	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08		1796146	241403227	29	42241											
RHOB	388	broad.mit.edu	37	chr2	20647664	20647664	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcacggatgacggccgcgcCatggccgtgcgcatccaagc	7	4	14	16	7	0	1	0	1	0	0	1	2	1	2	4	3	2	2	4	3	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:20647664C>A	uc002rdv.2	+	1	830	c.438C>A	c.(436-438)GCC>GCA	p.A146A		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	146					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		ACGGCCGCGCCATGGCCGTGC	0.662													44	94					9.39024e-22	2.43946e-21	1	0	A	20647664	A	A	20647664	2	1	234	1	0	0	0	0	0	0	0	1	13397	581	21	4		4	RHOB	2	20647664	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	18851518	20647664	222551709	30	42242											
APOB	338	broad.mit.edu	37	chr2	21231924	21231924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaaggtagctttctgaagagCctgaagactgacttcaaagg	13	9	12	7	0	2	5	1	3	1	2	2	6	2	5	1	2	2	2	1	2	5	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:21231924C>T	uc002red.2	-	26	7944	c.7816G>A	c.(7816-7818)GCT>ACT	p.A2606T		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2606					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCTGAAGAGCCTGAAGACTG	0.418													28	65					0	0	0	0	T	21231924	T	T	21231924	3	4	234	1	0	0	0	0	1	0	0	0	785	739	26	4	5891	4	APOB	2	21231924	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	584260	21231924	221967449	31	42243											
MAP4K3	8491	broad.mit.edu	37	chr2	39505576	39505576	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgatgtttcatgaagttcaTtaagattgagggtataaatc	13	16	9	3	0	2	4	2	3	0	1	3	4	2	4	0	1	0	3	0	1	5	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:39505576T>C	uc002rro.2	-	24	1857	c.1766A>G	c.(1765-1767)AAT>AGT	p.N589S	MAP4K3_uc002rrp.2_Missense_Mutation_p.N568S|MAP4K3_uc010yns.1_Missense_Mutation_p.N142S	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	589	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				ATGAAGTTCATTAAGATTGAG	0.254													3	22					0	0	0	0	C	39505576	C	C	39505576	3	2	234	1	0	0	0	0	1	0	0	0	9314	1493	52	5	962	5	MAP4K3	2	39505576	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	18273652	39505576	203693797	32	42244											
COX7A2L	9167	broad.mit.edu	37	chr2	42580403	42580403	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttttcccagcataatcataCactgtggaatcggaggtcag	11	12	9	9	1	2	0	2	0	0	0	4	2	3	2	1	3	2	1	1	3	3	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:42580403C>A	uc002rsk.2	-	2	208	c.153G>T	c.(151-153)GTG>GTT	p.V51V	COX7A2L_uc002rsl.2_RNA	NM_004718	NP_004709	O14548	COX7R_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 2	51					respiratory electron transport chain	mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0						CATAATCATACACTGTGGAAT	0.403													16	57					2.23348e-06	4.54163e-06	1	0	A	42580403	A	A	42580403	2	1	234	1	0	0	0	0	0	0	0	1	3796	465	17	4		4	COX7A2L	2	42580403	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	3074827	42580403	200618970	33	42245											
ABCG8	64241	broad.mit.edu	37	chr2	44104829	44104829	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgcggtctcaggagataaagTaagcggggaaggcctcgggt	10	6	17	8	4	1	1	1	0	1	1	3	3	1	2	1	6	1	1	1	6	4	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:44104829T>A	uc002rtq.2	+	12	1974	c.1884_splice	c.e12+2	p.K628_splice	ABCG8_uc010yoa.1_Splice_Site_p.K627_splice	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8						cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GGAGATAAAGTAAGCGGGGAA	0.507											OREG0014582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	81					0	0	0	0	A	44104829	A	A	44104829	5	1	234	1	0	0	0	0	0	0	1	0	72	1652	57	5	1932	5	ABCG8	2	44104829	Splice_Site	SNP	T	TCGA-CV-7242-01A-11D-2012-08	1524426	44104829	199094544	34	42246											
FSHR	2492	broad.mit.edu	37	chr2	49189901	49189901	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctaaatgacttagagggaCaagtatgtaagtggaaccac	15	8	12	6	0	0	2	0	1	0	1	0	4	0	4	1	3	1	3	1	3	7	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:49189901C>G	uc002rww.2	-	10	2133	c.2059G>C	c.(2059-2061)GTC>CTC	p.V687L	FSHR_uc002rwx.2_Missense_Mutation_p.V625L|FSHR_uc010fbn.2_Missense_Mutation_p.V661L	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	687	Cytoplasmic (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	CTTAGAGGGACAAGTATGTAA	0.343									Gonadal_Dysgenesis_46_XX				13	44					0	0	0	0	G	49189901	G	G	49189901	3	3	234	1	0	0	0	0	1	0	0	0	6107	478	17	4	32	4	FSHR	2	49189901	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	5085072	49189901	194009472	35	42247											
FSHR	2492	broad.mit.edu	37	chr2	49381534	49381534	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagctcaggaatgccagcAaagagaccaggagcagggcc	14	2	13	12	0	1	1	1	0	0	1	1	4	1	3	4	3	4	3	4	3	3	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:49381534A>G	uc002rww.2	-	1	97	c.23T>C	c.(22-24)TTG>TCG	p.L8S	FSHR_uc002rwx.2_Missense_Mutation_p.L8S|FSHR_uc010fbn.2_Missense_Mutation_p.L8S|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	8					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GAATGCCAGCAAAGAGACCAG	0.488									Gonadal_Dysgenesis_46_XX				9	45					0	0	0	0	G	49381534	G	G	49381534	3	3	234	1	0	0	0	0	1	0	0	0	6107	131	5	5	2104	5	FSHR	2	49381534	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	191633	49381534	193817839	36	42248											
NRXN1	9378	broad.mit.edu	37	chr2	50780107	50780107	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatcttcatcttaggatcTccttgcttggcaagtcgaga	8	14	10	9	1	4	1	1	0	3	1	6	4	4	3	1	3	1	2	1	3	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:50780107T>A	uc010fbq.2	-	9	2974	c.1497A>T	c.(1495-1497)GGA>GGT	p.G499G	NRXN1_uc002rxb.3_Silent_p.G131G|NRXN1_uc002rxe.3_Silent_p.G459G|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TCTTAGGATCTCCTTGCTTGG	0.408													36	130					0	0	0	0	A	50780107	A	A	50780107	2	1	234	1	0	0	0	0	0	0	0	1	10719	1538	54	5		5	NRXN1	2	50780107	Silent	SNP	T	TCGA-CV-7242-01A-11D-2012-08	1398573	50780107	192419266	37	42249											
NRXN1	9378	broad.mit.edu	37	chr2	50780123	50780123	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatctccttgcttggcaagtCgagataattccagcctcaca	10	11	8	12	1	2	1	1	0	1	1	5	3	3	1	3	1	2	2	3	1	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:50780123C>A	uc010fbq.2	-	9	2958	c.1481G>T	c.(1480-1482)CGA>CTA	p.R494L	NRXN1_uc002rxb.3_Missense_Mutation_p.R126L|NRXN1_uc002rxe.3_Missense_Mutation_p.R454L|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CTTGGCAAGTCGAGATAATTC	0.403													32	137					6.84511e-11	1.56644e-10	1	0	A	50780123	A	A	50780123	3	1	234	1	0	0	0	0	1	0	0	0	10719	884	31	3	3485	3	NRXN1	2	50780123	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	16	50780123	192419250	38	42250											
DYSF	8291	broad.mit.edu	37	chr2	71795363	71795363	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cacaacgggcctcacctaccCcaagttttctgacgtcacgg	9	8	8	16	3	3	1	2	1	1	0	3	1	3	1	4	2	2	1	4	2	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:71795363C>A	uc002sie.2	+	26	3081	c.2705C>A	c.(2704-2706)CCC>CAC	p.P902H	DYSF_uc010feg.2_Missense_Mutation_p.P933H|DYSF_uc010feh.2_Missense_Mutation_p.P888H|DYSF_uc002sig.3_Missense_Mutation_p.P888H|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.P902H|DYSF_uc010fef.2_Missense_Mutation_p.P919H|DYSF_uc010fei.2_Missense_Mutation_p.P919H|DYSF_uc010fek.2_Missense_Mutation_p.P920H|DYSF_uc010fej.2_Missense_Mutation_p.P889H|DYSF_uc010fel.2_Missense_Mutation_p.P889H|DYSF_uc010feo.2_Missense_Mutation_p.P934H|DYSF_uc010fem.2_Missense_Mutation_p.P903H|DYSF_uc010fen.2_Missense_Mutation_p.P920H|DYSF_uc002sif.2_Missense_Mutation_p.P903H	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	902	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CTCACCTACCCCAAGTTTTCT	0.607													67	227					2.01871e-26	5.35876e-26	1	0	A	71795363	A	A	71795363	3	1	234	1	0	0	0	0	1	0	0	0	4881	623	22	4	2999	4	DYSF	2	71795363	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	21015240	71795363	171404010	39	42251											
CYP26B1	56603	broad.mit.edu	37	chr2	72361997	72361997	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcactgcagcttctcccGgatggccttctccagcccct	4	11	9	17	1	2	0	0	0	2	0	4	1	2	1	5	2	4	3	5	2	0	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:72361997G>A	uc002sih.1	-	4	754	c.754C>T	c.(754-756)CGG>TGG	p.R252W	CYP26B1_uc010yra.1_Missense_Mutation_p.R235W|CYP26B1_uc010yrb.1_Missense_Mutation_p.R177W	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	252					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2						AGCTTCTCCCGGATGGCCTTC	0.602													18	36					0	0	0	0	A	72361997	A	A	72361997	3	1	234	1	0	0	0	0	1	0	0	0	4173	1115	39	1	796	1	CYP26B1	2	72361997	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	566634	72361997	170837376	40	42252											
ALMS1	7840	broad.mit.edu	37	chr2	73777441	73777441	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagctcaggtgctaggcAcaagagatgatgacctctca	11	8	10	12	0	2	3	2	2	1	1	4	4	3	3	2	2	2	3	2	2	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:73777441A>C	uc002sje.1	+	15	10069	c.9958A>C	c.(9958-9960)ACA>CCA	p.T3320P	ALMS1_uc002sjf.1_Missense_Mutation_p.T3276P|ALMS1_uc002sjg.2_Missense_Mutation_p.T2706P|ALMS1_uc002sjh.1_Missense_Mutation_p.T2706P|ALMS1_uc010fev.1_Intron	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3318					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GGTGCTAGGCACAAGAGATGA	0.438													16	60					0	0	0	0	C	73777441	C	C	73777441	3	2	234	1	0	0	0	0	1	0	0	0	535	159	6	5	10002	5	ALMS1	2	73777441	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	1415444	73777441	169421932	41	42253											
REG1B	5968	broad.mit.edu	37	chr2	79312665	79312665	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccagcattagcactgctcGgggatccagtgtcccaggac	9	7	12	13	1	0	0	0	0	0	0	3	2	2	2	3	3	4	3	3	3	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:79312665G>C	uc002sny.2	-	5	498	c.386C>G	c.(385-387)CCG>CGG	p.P129R		NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	129	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						AGCACTGCTCGGGGATCCAGT	0.557													15	51					0	0	0	0	C	79312665	C	C	79312665	3	2	234	1	0	0	0	0	1	0	0	0	13276	1116	39	3	122	3	REG1B	2	79312665	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	5535224	79312665	163886708	42	42254											
TGOLN2	10618	broad.mit.edu	37	chr2	85554620	85554620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccgacttgttgggggtgtCttctggggtctgcgcctccg	2	12	15	12	3	3	0	0	0	3	0	4	1	4	0	3	4	1	1	3	4	0	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:85554620C>T	uc010fgd.1	-	2	524	c.235G>A	c.(235-237)GAC>AAC	p.D79N	TGOLN2_uc002soz.2_Missense_Mutation_p.D79N|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_Missense_Mutation_p.D79N|TGOLN2_uc002spc.1_Missense_Mutation_p.D79N	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	79	Extracellular (Potential).|14 X 14 AA tandem repeats.|2.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						TTGGGGGTGTCTTCTGGGGTC	0.592													127	378					0	0	0	0	T	85554620	T	T	85554620	3	4	234	1	0	0	0	0	1	0	0	0	15902	913	32	2	1090	2	TGOLN2	2	85554620	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	6241955	85554620	157644753	43	42255											
FER1L5	90342	broad.mit.edu	37	chr2	97361322	97361322	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaattcggggaagagtcccTgaggacagaacccatcaggg	12	5	15	9	1	1	3	1	1	0	2	3	6	2	6	2	5	1	0	2	5	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:97361322T>A	uc010fia.2	+	34	3899	c.3899T>A	c.(3898-3900)CTG>CAG	p.L1300Q	FER1L5_uc002sws.3_Missense_Mutation_p.L18Q|FER1L5_uc010fib.1_RNA|FER1L5_uc002swt.3_Missense_Mutation_p.L18Q|FER1L5_uc010yus.1_Missense_Mutation_p.L18Q	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1300						integral to membrane				ovary(1)	1						GAAGAGTCCCTGAGGACAGAA	0.592													4	10					0	0	0	0	A	97361322	A	A	97361322	3	1	234	1	0	0	0	0	1	0	0	0	5846	1580	55	5	4033	5	FER1L5	2	97361322	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	11806702	97361322	145838051	44	42256											
CKAP2L	150468	broad.mit.edu	37	chr2	113514482	113514482	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatttaccatttccttgatCtgttaactgctgctttgtag	8	18	6	9	0	1	1	0	1	1	0	2	1	2	1	2	0	4	4	2	0	3	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:113514482C>A	uc002tie.2	-	4	545	c.466G>T	c.(466-468)GAT>TAT	p.D156Y	CKAP2L_uc002tif.2_5'UTR|CKAP2L_uc010yxp.1_5'UTR|CKAP2L_uc010yxq.1_5'UTR	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	156						centrosome					0						TTTCCTTGATCTGTTAACTGC	0.353													15	68					0.000219431	0.00042377	1	0	A	113514482	A	A	113514482	3	1	234	1	0	0	0	0	1	0	0	0	3458	913	32	2	1795	2	CKAP2L	2	113514482	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	16153160	113514482	129684891	45	42257											
ERCC3	2071	broad.mit.edu	37	chr2	128036885	128036885	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggggttcatggtgtacagcaAgattcgtttcttggttttga	7	16	13	5	1	2	2	1	1	1	1	3	2	2	2	0	4	2	5	0	4	2	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:128036885A>G	uc002toh.1	-	10	1689	c.1594T>C	c.(1594-1596)TTG>CTG	p.L532L	ERCC3_uc002toe.1_Silent_p.L287L|ERCC3_uc002tof.1_Silent_p.L468L|ERCC3_uc002tog.1_Silent_p.L468L	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	532					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		GTGTACAGCAAGATTCGTTTC	0.403			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				10	38					0	0	0	0	G	128036885	G	G	128036885	2	3	234	1	0	0	0	0	0	0	0	1	5238	69	3	5		5	ERCC3	2	128036885	Silent	SNP	A	TCGA-CV-7242-01A-11D-2012-08	14522403	128036885	115162488	46	42258											
THSD7B	80731	broad.mit.edu	37	chr2	137814036	137814036	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtcccggaggagtccaGagtcgggcagtgtggtgttt	5	11	18	7	2	0	1	0	0	0	1	3	3	2	3	2	5	0	2	2	5	0	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:137814036G>T	uc002tva.1	+	2	93	c.93G>T	c.(91-93)CAG>CAT	p.Q31H	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_5'UTR	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GAGGAGTCCAGAGTCGGGCAG	0.498													14	51					8.60227e-14	2.03885e-13	1	0	T	137814036	T	T	137814036	3	4	234	1	0	0	0	0	1	0	0	0	15946	933	33	2	99	2	THSD7B	2	137814036	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	9777151	137814036	105385337	47	42259											
THSD7B	80731	broad.mit.edu	37	chr2	137852609	137852609	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaacgtgaagcacatggctAttggaggtggaaaggagtgt	12	8	17	4	1	0	1	0	1	0	0	0	5	0	5	0	6	2	2	0	6	4	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:137852609A>G	uc002tva.1	+	3	1024	c.1024A>G	c.(1024-1026)ATT>GTT	p.I342V	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.I232V	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCACATGGCTATTGGAGGTGG	0.537													12	41					0	0	0	0	G	137852609	G	G	137852609	3	3	234	1	0	0	0	0	1	0	0	0	15946	449	16	5	1034	5	THSD7B	2	137852609	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	38573	137852609	105346764	48	42260											
ERMN	57471	broad.mit.edu	37	chr2	158178042	158178042	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attctatcactcgaacttcaTcttcatcattattgcaatta	12	17	2	10	1	6	0	4	0	2	0	7	1	6	0	0	0	2	1	0	0	5	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:158178042T>C	uc002tzh.2	-	3	858	c.596A>G	c.(595-597)GAT>GGT	p.D199G	ERMN_uc010zcj.1_Missense_Mutation_p.D93G|ERMN_uc010zck.1_Missense_Mutation_p.D179G|ERMN_uc002tzi.2_Missense_Mutation_p.D212G	NM_020711	NP_065762	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein isoform b	199						cytoplasm|cytoskeleton				ovary(1)|skin(1)	2						TCGAACTtcatcttcatcatt	0.323													6	110					0	0	0	0	C	158178042	C	C	158178042	3	2	234	1	0	0	0	0	1	0	0	0	5259	1435	50	5	262	5	ERMN	2	158178042	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	20325433	158178042	85021331	49	42261											
ACVR1	90	broad.mit.edu	37	chr2	158594062	158594062	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcaacagtcagttttcaatTtgtcgagggaattatcaatt	12	15	8	6	1	4	0	4	0	0	0	5	2	4	1	0	1	1	1	0	1	5	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:158594062T>A	uc002tzm.3	-	12	1850	c.1511A>T	c.(1510-1512)AAA>ATA	p.K504I	ACVR1_uc002tzn.3_Missense_Mutation_p.K504I|ACVR1_uc010fog.2_Missense_Mutation_p.K504I	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	504	Cytoplasmic (Potential).				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	AGTTTTCAATTTGTCGAGGGA	0.418													8	46					0	0	0	0	A	158594062	A	A	158594062	3	1	234	1	0	0	0	0	1	0	0	0	220	1841	64	5	22	5	ACVR1	2	158594062	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	416020	158594062	84605311	50	42262											
BAZ2B	29994	broad.mit.edu	37	chr2	160206241	160206241	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagaggtgataaagcaaatGgatttaagccaacaggattc	17	8	11	5	0	0	2	0	1	0	1	1	5	0	4	1	3	3	1	1	3	6	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:160206241G>A	uc002uao.2	-	28	5193	c.4841C>T	c.(4840-4842)CCA>CTA	p.P1614L	BAZ2B_uc002uap.2_Missense_Mutation_p.P1578L	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1614					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TAAAGCAAATGGATTTAAGCC	0.433													7	36					0	0	0	0	A	160206241	A	A	160206241	3	1	234	1	0	0	0	0	1	0	0	0	1334	1348	47	4	1705	4	BAZ2B	2	160206241	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	1612179	160206241	82993132	51	42263											
TTN	7273	broad.mit.edu	37	chr2	179411788	179411788	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggccttgctaacacctgcAgcattgagtgcataagttct	9	12	9	11	0	1	1	0	1	1	0	1	1	1	1	2	1	5	5	2	1	2	5	rs138888307	by1000genomes	TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:179411788A>T	uc010zfg.1	-	289	86984	c.86760T>A	c.(86758-86760)GCT>GCA	p.A28920A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.A22615A|TTN_uc010zfi.1_Silent_p.A22548A|TTN_uc010zfj.1_Silent_p.A22423A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29847							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACACCTGCAGCATTGAGTG	0.393													52	191					0	0	0	0	T	179411788	T	T	179411788	2	4	234	1	0	0	0	0	0	0	0	1	16803	175	7	5		5	TTN	2	179411788	Silent	SNP	A	TCGA-CV-7242-01A-11D-2012-08	19205547	179411788	63787585	52	42264											
TTN	7273	broad.mit.edu	37	chr2	179458745	179458745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtactgttctccacaaccaCacagtatttgccggaatctg	10	12	7	12	1	2	0	0	0	2	0	3	1	2	1	3	1	3	3	3	1	4	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:179458745C>T	uc010zfg.1	-	246	50895	c.50671G>A	c.(50671-50673)GTG>ATG	p.V16891M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V10586M|TTN_uc010zfi.1_Missense_Mutation_p.V10519M|TTN_uc010zfj.1_Missense_Mutation_p.V10394M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17818							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCACAACCACACAGTATTTG	0.403													43	147					0	0	0	0	T	179458745	T	T	179458745	3	4	234	1	0	0	0	0	1	0	0	0	16803	478	17	4	49868	4	TTN	2	179458745	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	46957	179458745	63740628	53	42265											
TTN	7273	broad.mit.edu	37	chr2	179571433	179571433	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taacatttgggattgggtcaCctccaacttttgcaatgaag	11	13	9	8	0	1	1	1	1	0	0	2	2	2	2	2	2	3	1	2	2	4	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:179571433C>A	uc010zfg.1	-	99	25660	c.25436G>T	c.(25435-25437)GGT>GTT	p.G8479V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G5140V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9406							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTGGGTCACCTCCAACTTT	0.368													31	98					2.85442e-18	7.21012e-18	1	0	A	179571433	A	A	179571433	3	1	234	1	0	0	0	0	1	0	0	0	16803	507	18	4	75405	4	TTN	2	179571433	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	112688	179571433	63627940	54	42266											
TTN	7273	broad.mit.edu	37	chr2	179581892	179581892	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcatagcaggtgtactgcccGgcatcgcctttgcctacttt	6	12	10	13	2	0	0	0	0	0	0	1	0	0	0	3	2	5	4	3	2	3	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:179581892G>T	uc010zfg.1	-	85	22061	c.21837C>A	c.(21835-21837)GCC>GCA	p.A7279A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.A3940A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8206							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTACTGCCCGGCATCGCCTT	0.483													19	41					5.35267e-07	1.11323e-06	1	0	T	179581892	T	T	179581892	2	4	234	1	0	0	0	0	0	0	0	1	16803	1103	39	3		3	TTN	2	179581892	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	10459	179581892	63617481	55	42267											
TTN	7273	broad.mit.edu	37	chr2	179595724	179595724	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcgaaagtatattctccacTatctttcttttctgtagaaa	11	17	4	9	1	4	1	0	0	4	1	6	2	4	1	1	0	0	2	1	0	6	8			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:179595724T>A	uc010zfg.1	-	57	14160	c.13936A>T	c.(13936-13938)AGT>TGT	p.S4646C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S1307C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5573							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTCTCCACTATCTTTCTTT	0.378													58	168					0	0	0	0	A	179595724	A	A	179595724	3	1	234	1	0	0	0	0	1	0	0	0	16803	1522	53	5	87073	5	TTN	2	179595724	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	13832	179595724	63603649	56	42268											
FRZB	2487	broad.mit.edu	37	chr2	183723523	183723523	+	Frame_Shift_Del	DEL	C	-	-																															gatatactcaccactgcttgCccctctacagtttccgttac																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:183723523delC	uc002upa.1	-	2	735	c.517delG	c.(517-519)GCAfs	p.A173fs		NM_001463	NP_001454	Q92765	SFRP3_HUMAN	frizzled-related protein precursor	173					brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			CCACTGCTTGCCCCTCTACAG	0.348													---	---	---								-	183723523	-	-	183723523	7	5	234	1	0	1	0	1	0	0	0	0	6099	739	26	0	480	0	FRZB	2	183723523	Frame_Shift_Del	DEL	C	TCGA-CV-7242-01A-11D-2012-08	4127799	183723523	59475850	57	42269											
GTF3C3	9330	broad.mit.edu	37	chr2	197650199	197650199	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catactgtttgttagaaataTatagttcagctgctatgtta	12	17	7	5	0	1	1	1	0	0	1	1	1	1	1	0	0	3	6	0	0	8	9	rs138093114		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:197650199T>C	uc002uts.2	-	7	1097	c.1007A>G	c.(1006-1008)TAT>TGT	p.Y336C	GTF3C3_uc010zgu.1_Missense_Mutation_p.Y336C|GTF3C3_uc002utu.2_Missense_Mutation_p.Y336C|GTF3C3_uc002utt.3_Missense_Mutation_p.Y11C	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	336	TPR 6.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						GTTAGAAATATATAGTTCAGC	0.358													8	33					0	0	0	0	C	197650199	C	C	197650199	3	2	234	1	0	0	0	0	1	0	0	0	6913	1406	49	5	1701	5	GTF3C3	2	197650199	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	13926676	197650199	45549174	58	42270											
WDR12	55759	broad.mit.edu	37	chr2	203747437	203747437	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactaataaattcttaccccTgtgtctgtccagtctacact	11	14	4	12	0	3	0	0	0	3	0	4	0	4	0	3	0	3	0	3	0	6	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:203747437T>C	uc002uzl.2	-	12	1941	c.1191A>G	c.(1189-1191)ACA>ACG	p.T397T	WDR12_uc010ftt.2_Intron	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	397	Sufficient for nucleolar localization.|WD 7.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						TTCTTACCCCTGTGTCTGTCC	0.308													3	103					0	0	0	0	C	203747437	C	C	203747437	2	2	234	1	0	0	0	0	0	0	0	1	17342	1567	55	5		5	WDR12	2	203747437	Silent	SNP	T	TCGA-CV-7242-01A-11D-2012-08	6097238	203747437	39451936	59	42271											
INO80D	54891	broad.mit.edu	37	chr2	206869167	206869167	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgttactgtgaagcctgtAggaggggctatagagctgtg	8	11	15	7	0	0	2	0	1	0	1	0	3	0	3	2	3	3	4	2	3	5	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:206869167A>G	uc002vaz.3	-	11	3414	c.3009T>C	c.(3007-3009)CCT>CCC	p.P1003P		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	Error:Variant_position_missing_in_Q53TQ3_after_alignment					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						TGAAGCCTGTAGGAGGGGCTA	0.547													3	11					0	0	0	0	G	206869167	G	G	206869167	2	3	234	1	0	0	0	0	0	0	0	1	7788	407	15	5		5	INO80D	2	206869167	Silent	SNP	A	TCGA-CV-7242-01A-11D-2012-08	3121730	206869167	36330206	60	42272											
MDH1B	130752	broad.mit.edu	37	chr2	207620218	207620218	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaattaggttgtagcaggcaGgagcagaggcactgataaaa	15	7	14	5	0	0	2	0	1	0	1	0	4	0	3	0	4	2	6	0	4	5	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:207620218G>A	uc002vbs.2	-	5	480	c.425C>T	c.(424-426)CCT>CTT	p.P142L	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Missense_Mutation_p.P142L|MDH1B_uc010fuj.2_Missense_Mutation_p.P44L|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	142					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		GTAGCAGGCAGGAGCAGAGGC	0.398													21	51					0	0	0	0	A	207620218	A	A	207620218	3	1	234	1	0	0	0	0	1	0	0	0	9462	1000	35	4	1163	4	MDH1B	2	207620218	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	751051	207620218	35579155	61	42273											
CPO	130749	broad.mit.edu	37	chr2	207834010	207834010	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgttctgccagaagctcaGatccagcccacctgtgagga	9	10	10	12	0	2	3	1	1	1	2	3	4	3	4	4	1	3	2	4	1	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:207834010G>T	uc002vby.2	+	9	1021	c.975G>T	c.(973-975)CAG>CAT	p.Q325H		NM_173077	NP_775100	Q8IVL8	CBPO_HUMAN	carboxypeptidase O precursor	325					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		CAGAAGCTCAGATCCAGCCCA	0.527													12	48					1.08611e-07	2.2915e-07	1	0	T	207834010	T	T	207834010	3	4	234	1	0	0	0	0	1	0	0	0	3835	933	33	2	1009	2	CPO	2	207834010	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	213792	207834010	35365363	62	42274											
SLC4A3	6508	broad.mit.edu	37	chr2	220501488	220501488	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgtccttgccctggtggcCgccgaaggcagcttcctggt	3	11	13	14	3	0	0	0	0	0	0	3	1	2	0	5	4	2	2	5	4	1	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:220501488C>T	uc002vmp.3	+	16	2696	c.2427C>T	c.(2425-2427)GCC>GCT	p.A809A	SLC4A3_uc002vmo.3_Silent_p.A836A|SLC4A3_uc010fwm.2_Silent_p.A359A|SLC4A3_uc010fwn.1_Silent_p.A318A	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	809	Helical; (Potential).|Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCTGGTGGCCGCCGAAGGCA	0.582													31	97					0	0	0	0	T	220501488	T	T	220501488	2	4	234	1	0	0	0	0	0	0	0	1	14719	639	23	1		1	SLC4A3	2	220501488	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	12667478	220501488	22697885	63	42275											
NMUR1	10316	broad.mit.edu	37	chr2	232390111	232390111	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgtggaacggggcccagcaGatgccaaacaccacgaccag	12	2	13	14	3	0	1	0	0	0	1	0	3	0	2	4	3	4	1	4	3	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:232390111G>C	uc002vry.3	-	3	1034	c.924C>G	c.(922-924)ATC>ATG	p.I308M		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	308	Helical; Name=6; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		GGGCCCAGCAGATGCCAAACA	0.657													7	36					0	0	0	0	C	232390111	C	C	232390111	3	2	234	1	0	0	0	0	1	0	0	0	10560	932	33	2	360	2	NMUR1	2	232390111	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	11888623	232390111	10809262	64	42276											
ALPP	250	broad.mit.edu	37	chr2	233246046	233246046	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctatgtgctcaaggacggCgcccggccggatgttaccga	7	7	15	12	5	1	0	1	0	0	0	1	3	1	2	3	5	2	3	3	5	3	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:233246046C>T	uc002vsq.2	+	10	1443	c.1278C>T	c.(1276-1278)GGC>GGT	p.G426G	ALPP_uc002vsr.2_RNA	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	426						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		TCAAGGACGGCGCCCGGCCGG	0.697													10	33					0	0	0	0	T	233246046	T	T	233246046	2	4	234	1	0	0	0	0	0	0	0	1	548	755	27	1		1	ALPP	2	233246046	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	855935	233246046	9953327	65	42277											
UGT1A8	54576	broad.mit.edu	37	chr2	234526223	234526224	+	5'Flank	INS	-	T	T																															atcattggcagtgagtgtgaINSttttttttttttttatgaca																								rs34872923		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	f50dc054-f0b0-4b11-be76-09ae612abc8e	g.chr2:234526223_234526224insT	uc002vup.2	+						UGT1A8_uc010zmv.1_5'Flank	NM_019076	NP_061949	Q9HAW9	UD18_HUMAN	UDP glycosyltransferase 1 family, polypeptide A8						drug metabolic process|fatty acid metabolic process|flavone metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme inhibitor activity|fatty acid binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|steroid binding			ovary(2)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGTGAGTGTGATTTTTTTTTTT	0.361											OREG0003838	type=REGULATORY REGION|Gene=UGT1A8|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---								T	234526224	T	T	234526223	6	5	234	0	1	1	1	0	0	0	0	0	17019	348	12	0		0	UGT1A8	2	234526223	5'Flank	INS	-	TCGA-CV-7242-01A-11D-2012-08	1280177	234526223	8673150	66	42278											
C2orf54	79919	broad.mit.edu	37	chr2	241831032	241831032	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagctgccctcagggaatccGggcatctgctgcaccccctc	7	7	10	17	1	2	0	1	0	1	0	4	1	3	1	4	2	4	4	4	2	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr2:241831032G>T	uc002wae.3	-	2	822	c.663C>A	c.(661-663)CCC>CCA	p.P221P	C2orf54_uc002wac.2_Silent_p.P53P|C2orf54_uc002wad.2_Silent_p.P72P	NM_001085437	NP_001078906	Q08AI8	CB054_HUMAN	hypothetical protein LOC79919 isoform 1	221											0		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		CAGGGAATCCGGGCATCTGCT	0.657													32	93					9.04072e-19	2.3076e-18	1	0	T	241831032	T	T	241831032	2	4	234	1	0	0	0	0	0	0	0	1	2185	1103	39	3		3	C2orf54	2	241831032	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	7304809	241831032	1368341	67	42279											
C3orf20	84077	broad.mit.edu	37	chr3	14769945	14769945	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcagcatcttctgttaacaGgtctgtttaccattgaatat	11	15	7	8	0	3	1	0	1	3	0	3	1	3	1	1	1	4	4	1	1	4	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr3:14769945G>T	uc003byy.2	+	12	2095	c.1691_splice	c.e12-1	p.G564_splice	C3orf20_uc003byz.2_Splice_Site_p.G442_splice|C3orf20_uc003bza.2_Splice_Site_p.G442_splice|C3orf20_uc003bzb.1_Splice_Site_p.G65_splice	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077							cytoplasm|integral to membrane				ovary(3)|skin(1)	4						TCTGTTAACAGGTCTGTTTAC	0.507													19	35					1.33834e-09	2.96956e-09	1	0	T	14769945	T	T	14769945	5	4	234	1	0	0	0	0	0	0	1	0	2223	1014	35	4	1728	4	C3orf20	3	14769945	Splice_Site	SNP	G	TCGA-CV-7242-01A-11D-2012-08		14769945	183252485	68	42280											
EPHA6	285220	broad.mit.edu	37	chr3	96533514	96533514	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggagctccccggcgccgcAggcagcgtcctcctccgaag	6	4	14	17	5	0	0	0	0	0	0	4	3	4	1	6	3	2	3	6	3	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr3:96533514A>T	uc010how.1	+	1	90	c.47A>T	c.(46-48)CAG>CTG	p.Q16L	EPHA6_uc003drp.1_Missense_Mutation_p.Q16L	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	Error:Variant_position_missing_in_Q9UF33_after_alignment						integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CCGGCGCCGCAGGCAGCGTCC	0.711													14	24					0	0	0	0	T	96533514	T	T	96533514	3	4	234	1	0	0	0	0	1	0	0	0	5195	188	7	5	49	5	EPHA6	3	96533514	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	81763569	96533514	101488916	69	42281											
EPHA6	285220	broad.mit.edu	37	chr3	97439201	97439201	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagctatggcattgtcatgTgggaggtcatgtcctatgga	8	12	15	6	0	2	0	2	0	0	0	3	3	3	3	1	5	1	2	1	5	2	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr3:97439201T>A	uc010how.1	+	15	2924	c.2881T>A	c.(2881-2883)TGG>AGG	p.W961R	EPHA6_uc003drt.2_Missense_Mutation_p.W353R|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	866	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CATTGTCATGTGGGAGGTCAT	0.463													16	60					0	0	0	0	A	97439201	A	A	97439201	3	1	234	1	0	0	0	0	1	0	0	0	5195	1696	59	5	3056	5	EPHA6	3	97439201	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	905687	97439201	100583229	70	42282											
DPPA4	55211	broad.mit.edu	37	chr3	109049491	109049491	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaactgtattaactccctCaaggagagcagtggaatttt	13	11	8	9	0	1	1	1	0	0	1	2	3	2	2	1	2	3	2	1	2	5	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr3:109049491C>A	uc003dxq.3	-	5	614	c.559G>T	c.(559-561)GAG>TAG	p.E187*	DPPA4_uc011bho.1_Intron|DPPA4_uc011bhp.1_Nonsense_Mutation_p.E187*	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	187						nucleus	protein binding			upper_aerodigestive_tract(1)	1						TTAACTCCCTCAAGGAGAGCA	0.577													20	75					8.00594e-06	1.61001e-05	1	0	A	109049491	A	A	109049491	4	1	234	1	0	0	0	0	0	1	0	0	4758	835	29	2	367	2	DPPA4	3	109049491	Nonsense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	11610290	109049491	88972939	71	42283											
POLQ	10721	broad.mit.edu	37	chr3	121208845	121208845	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaacatgtctgatgttctTgattcccattctggaaatta	10	16	8	7	0	3	2	0	2	3	0	4	4	4	4	1	2	1	1	1	2	3	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr3:121208845T>C	uc003eee.3	-	16	3062	c.2933A>G	c.(2932-2934)CAA>CGA	p.Q978R	POLQ_uc003eed.2_Missense_Mutation_p.Q150R	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	978					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CTGATGTTCTTGATTCCCATT	0.353								DNA_polymerases_(catalytic_subunits)					16	44					0	0	0	0	C	121208845	C	C	121208845	3	2	234	1	0	0	0	0	1	0	0	0	12263	1812	63	5	4899	5	POLQ	3	121208845	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	12159354	121208845	76813585	72	42284											
COL6A6	131873	broad.mit.edu	37	chr3	130287207	130287207	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaccaagggcgcccggccCaacatcagaaagtttctcat	11	6	8	16	2	2	1	2	0	1	1	3	1	2	1	4	2	1	1	4	2	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr3:130287207C>A	uc010htl.2	+	5	2191	c.2160C>A	c.(2158-2160)CCC>CCA	p.P720P		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	720	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GCGCCCGGCCCAACATCAGAA	0.498													32	95					1.61788e-16	4.03089e-16	1	0	A	130287207	A	A	130287207	2	1	234	1	0	0	0	0	0	0	0	1	3718	581	21	4		4	COL6A6	3	130287207	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	9078362	130287207	67735223	73	42285											
ATR	545	broad.mit.edu	37	chr3	142184024	142184024	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acatcatgatgtagaactttCcatctgagccttttaaagaa	14	13	6	8	0	2	4	1	2	1	2	3	4	3	4	2	0	2	1	2	0	5	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr3:142184024C>T	uc003eux.3	-	41	7078	c.6956G>A	c.(6955-6957)GGA>GAA	p.G2319E	ATR_uc003euy.1_Missense_Mutation_p.G205E	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2319					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						GTAGAACTTTCCATCTGAGCC	0.333								Other_conserved_DNA_damage_response_genes					8	24					0	0	0	0	T	142184024	T	T	142184024	3	4	234	1	0	0	0	0	1	0	0	0	1206	855	30	2	1006	2	ATR	3	142184024	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	11896817	142184024	55838406	74	42286											
NLGN1	22871	broad.mit.edu	37	chr3	173997383	173997383	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccttgcaatttctccaaaaAtgatgtgatgctgagtgcag	11	13	9	8	0	1	3	0	3	1	0	3	3	2	3	2	0	3	3	2	0	3	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr3:173997383A>G	uc003fio.1	+	6	2015	c.1592A>G	c.(1591-1593)AAT>AGT	p.N531S	NLGN1_uc010hww.1_Missense_Mutation_p.N571S|NLGN1_uc003fip.1_Missense_Mutation_p.N531S	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	548	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TTCTCCAAAAATGATGTGATG	0.403													11	62					0	0	0	0	G	173997383	G	G	173997383	3	3	234	1	0	0	0	0	1	0	0	0	10515	101	4	5	1606	5	NLGN1	3	173997383	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	31813359	173997383	24025047	75	42287											
LSG1	55341	broad.mit.edu	37	chr3	194365325	194365325	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atggaaaaaagttttgtcaaCgatattttcaatctgctttg	13	16	7	5	1	3	0	2	0	1	0	3	2	3	1	0	1	2	2	0	1	6	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr3:194365325C>T	uc003fui.2	-	13	2089	c.1774G>A	c.(1774-1776)GTT>ATT	p.V592I		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	592					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		GTTTTGTCAACGATATTTTCA	0.328													9	42					0	0	0	0	T	194365325	T	T	194365325	3	4	234	1	0	0	0	0	1	0	0	0	9099	536	19	1	210	1	LSG1	3	194365325	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	20367942	194365325	3657105	76	42288											
WHSC1	7468	broad.mit.edu	37	chr4	1936943	1936943	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagatgctgaagctgaggAcacacccaggaaaagactca	17	4	11	9	0	1	5	1	2	0	3	1	7	1	7	1	2	2	2	1	2	4	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:1936943A>T	uc003gdz.3	+	7	1804	c.1628A>T	c.(1627-1629)GAC>GTC	p.D543V	WHSC1_uc003geb.3_Missense_Mutation_p.D543V|WHSC1_uc003gec.3_Missense_Mutation_p.D543V|WHSC1_uc003ged.3_Missense_Mutation_p.D543V|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdy.1_Missense_Mutation_p.D543V|WHSC1_uc010icd.1_Missense_Mutation_p.D543V|WHSC1_uc003gea.1_Missense_Mutation_p.D543V|WHSC1_uc010ice.1_Missense_Mutation_p.D543V|WHSC1_uc003geh.1_Missense_Mutation_p.D543V	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	543					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GAAGCTGAGGACACACCCAGG	0.458			T	IGH@	MM								15	39					0	0	0	0	T	1936943	T	T	1936943	3	4	234	1	0	0	0	0	1	0	0	0	17430	275	10	5	1650	5	WHSC1	4	1936943	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08		1936943	189217333	77	42289											
ABLIM2	84448	broad.mit.edu	37	chr4	8037890	8037890	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatacctcgccgtagctctGcctgtcccctgcagagtggc	5	9	10	17	2	1	1	0	0	1	1	3	1	2	1	6	1	4	3	6	1	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:8037890G>A	uc003gko.2	-	10	1176	c.1033C>T	c.(1033-1035)CAG>TAG	p.Q345*	ABLIM2_uc003gkl.2_Nonsense_Mutation_p.Q95*|ABLIM2_uc003gkj.3_Nonsense_Mutation_p.Q345*|ABLIM2_uc003gkm.3_Nonsense_Mutation_p.Q345*|ABLIM2_uc003gkp.2_Nonsense_Mutation_p.Q345*|ABLIM2_uc003gkq.2_Nonsense_Mutation_p.Q345*|ABLIM2_uc003gkr.2_Nonsense_Mutation_p.Q345*|ABLIM2_uc003gks.3_Nonsense_Mutation_p.Q345*|ABLIM2_uc011bwl.1_Nonsense_Mutation_p.Q350*	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	345					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3						CCGTAGCTCTGCCTGTCCCCT	0.592													4	13					0	0	0	0	A	8037890	A	A	8037890	4	1	234	1	0	0	0	0	0	1	0	0	95	1328	46	4	1006	4	ABLIM2	4	8037890	Nonsense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	6100947	8037890	183116386	78	42290											
DCAF16	54876	broad.mit.edu	37	chr4	17805350	17805350	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgctccatttagagtggCatgatctctagagagccggc	9	10	12	10	1	1	3	0	1	1	2	3	4	2	3	2	2	2	2	2	2	2	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:17805350C>A	uc003gpn.2	-	3	1476	c.415G>T	c.(415-417)GCC>TCC	p.A139S	DCAF16_uc003gpo.2_RNA	NM_017741	NP_060211	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	139						CUL4 RING ubiquitin ligase complex				ovary(1)	1						TTTAGAGTGGCATGATCTCTA	0.488													38	105					1.47197e-15	3.61797e-15	1	0	A	17805350	A	A	17805350	3	1	234	1	0	0	0	0	1	0	0	0	4285	710	25	4	239	4	DCAF16	4	17805350	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	9767460	17805350	173348926	79	42291											
SGCB	6443	broad.mit.edu	37	chr4	52895030	52895030	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgcatgccgatgtcacttgTaatagaagttttgttgtttt	8	18	9	6	1	1	1	1	0	0	1	1	2	1	1	1	0	2	5	1	0	3	8	rs116157710	by1000genomes	TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:52895030T>C	uc003gzj.2	-	4	547	c.487A>G	c.(487-489)ACA>GCA	p.T163A	SGCB_uc011bzp.1_Missense_Mutation_p.T93A	NM_000232	NP_000223	Q16585	SGCB_HUMAN	sarcoglycan, beta	163	Extracellular (Potential).|Cys-rich.				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma					0			GBM - Glioblastoma multiforme(4;7.63e-12)|LUSC - Lung squamous cell carcinoma(32;0.00204)			ATGTCACTTGTAATAGAAGTT	0.343													3	49					0	0	0	0	C	52895030	C	C	52895030	3	2	234	1	0	0	0	0	1	0	0	0	14265	1638	57	5	481	5	SGCB	4	52895030	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	35089680	52895030	138259246	80	42292											
KIAA1211	57482	broad.mit.edu	37	chr4	57190366	57190366	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagagaagaggcccgagactGcagtgtccaggcttgagcgc	11	5	15	10	2	0	4	0	1	0	3	1	6	1	4	2	2	2	2	2	2	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:57190366G>A	uc003hbk.2	+	10	3866	c.3475G>A	c.(3475-3477)GCA>ACA	p.A1159T	KIAA1211_uc010iha.2_Missense_Mutation_p.A1152T	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	1159										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GCCCGAGACTGCAGTGTCCAG	0.547													19	60					0	0	0	0	A	57190366	A	A	57190366	3	1	234	1	0	0	0	0	1	0	0	0	8254	1319	46	4	3501	4	KIAA1211	4	57190366	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	4295336	57190366	133963910	81	42293											
CCDC158	339965	broad.mit.edu	37	chr4	77303790	77303790	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttccatttgactctggataCtattggcttggcttcgagca	7	16	9	9	1	1	1	0	1	1	0	3	3	2	2	1	3	2	3	1	3	2	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:77303790C>A	uc003hkb.3	-	7	1040	c.887G>T	c.(886-888)AGT>ATT	p.S296I	CCDC158_uc003hkd.2_Missense_Mutation_p.S296I	NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	296	Potential.									skin(3)|ovary(2)|pancreas(1)	6						ACTCTGGATACTATTGGCTTG	0.333													12	38					0.00010058	0.000195796	1	0	A	77303790	A	A	77303790	3	1	234	1	0	0	0	0	1	0	0	0	2803	565	20	4	2526	4	CCDC158	4	77303790	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	20113424	77303790	113850486	82	42294											
HERC5	51191	broad.mit.edu	37	chr4	89414186	89414186	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcatttagtggagaaattggGtatgacctcggaggagtcaa	12	11	13	5	1	2	2	2	1	0	1	3	5	2	4	1	4	0	1	1	4	4	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:89414186G>A	uc003hrt.2	+	17	2310	c.2157G>A	c.(2155-2157)GGG>GGA	p.G719G	HERC5_uc011cdm.1_Silent_p.G357G	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	719	HECT.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		GAGAAATTGGGTATGACCTCG	0.398													12	50					0	0	0	0	A	89414186	A	A	89414186	2	1	234	1	0	0	0	0	0	0	0	1	7100	1248	44	4		4	HERC5	4	89414186	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	12110396	89414186	101740090	83	42295											
MMRN1	22915	broad.mit.edu	37	chr4	90856410	90856410	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttatcaactgaacaggtaTcagaccagaagaatgctcca	15	10	7	9	0	2	4	2	1	0	3	3	4	3	4	2	1	3	2	2	1	6	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:90856410T>A	uc003hst.2	+	6	1650	c.1579T>A	c.(1579-1581)TCA>ACA	p.S527T	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.S269T	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	527					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TGAACAGGTATCAGACCAGAA	0.363													18	62					0	0	0	0	A	90856410	A	A	90856410	3	1	234	1	0	0	0	0	1	0	0	0	9723	1435	50	5	1601	5	MMRN1	4	90856410	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	1442224	90856410	100297866	84	42296											
UNC5C	8633	broad.mit.edu	37	chr4	96140416	96140416	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagggcatagacaggtcctCtgtacatggctgcagctgac	9	8	13	11	0	1	2	0	1	1	1	2	2	2	2	1	3	3	6	1	3	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:96140416C>G	uc003htp.1	-	9	1503	c.1349G>C	c.(1348-1350)AGA>ACA	p.R450T	UNC5C_uc010ilc.1_Missense_Mutation_p.R469T|UNC5C_uc003htq.2_Missense_Mutation_p.R469T	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	450	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GACAGGTCCTCTGTACATGGC	0.493													84	224					0	0	0	0	G	96140416	G	G	96140416	3	3	234	1	0	0	0	0	1	0	0	0	17061	913	32	2	1478	2	UNC5C	4	96140416	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	5284006	96140416	95013860	85	42297											
ADH7	131	broad.mit.edu	37	chr4	100349102	100349102	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggactggtttgcccttgcatGtaaatctggtggtgccatca	7	13	12	9	0	2	0	1	0	1	0	2	1	2	1	2	4	3	3	2	4	2	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:100349102G>T	uc003huv.1	-	5	527	c.428C>A	c.(427-429)ACA>AAA	p.T143K		NM_000673	NP_000664	P40394	ADH7_HUMAN	class IV alcohol dehydrogenase, mu or sigma	143					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			lung(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	GCCCTTGCATGTAAATCTGGT	0.403													26	90					7.26314e-15	1.75566e-14	1	0	T	100349102	T	T	100349102	3	4	234	1	0	0	0	0	1	0	0	0	313	1377	48	4	752	4	ADH7	4	100349102	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	4208686	100349102	90805174	86	42298											
ALPK1	80216	broad.mit.edu	37	chr4	113351810	113351811	+	Frame_Shift_Ins	INS	-	G	G																															cagtgcacagaaggctccatINSggggagacagggacggtcca																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:113351810_113351811insG	uc003iap.3	+	11	1386_1387	c.1107_1108insG	c.(1105-1110)CATGGGfs	p.H369fs	ALPK1_uc003ian.3_Frame_Shift_Ins_p.H369fs|ALPK1_uc011cfx.1_Frame_Shift_Ins_p.H291fs|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Frame_Shift_Ins_p.H197fs	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	369_370							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		GAAGGCTCCATGGGGAGACAGG	0.515													---	---	---								G	113351811	G	G	113351810	7	5	234	1	0	1	1	0	0	0	0	0	544	1461	51	0	1141	0	ALPK1	4	113351810	Frame_Shift_Ins	INS	-	TCGA-CV-7242-01A-11D-2012-08	13002708	113351810	77802466	87	42299											
C4orf31	79625	broad.mit.edu	37	chr4	121957963	121957963	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcccatctcttctcactTggatttggacagcatccaga	8	14	7	12	0	2	1	1	0	2	1	6	3	4	3	2	2	1	2	2	2	0	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:121957963T>A	uc003idq.1	-	4	1690	c.1163A>T	c.(1162-1164)CAA>CTA	p.Q388L		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	388											0						TCTTCTCACTTGGATTTGGAC	0.428													29	71					0	0	0	0	A	121957963	A	A	121957963	3	1	234	1	0	0	0	0	1	0	0	0	2271	1812	63	5	547	5	C4orf31	4	121957963	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	8606153	121957963	69196313	88	42300											
GRIA2	2891	broad.mit.edu	37	chr4	158281238	158281238	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgcgacaccatgaaagttgGtggaaacctggattccaaag	13	9	11	8	1	0	1	0	1	0	0	1	4	1	3	3	3	2	1	3	3	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:158281238G>T	uc003ipm.3	+	13	2693	c.2234G>T	c.(2233-2235)GGT>GTT	p.G745V	GRIA2_uc011cit.1_Missense_Mutation_p.G698V|GRIA2_uc003ipl.3_Missense_Mutation_p.G745V|GRIA2_uc003ipk.3_Missense_Mutation_p.G698V|GRIA2_uc010iqh.1_RNA|GRIA2_uc011ciu.1_Missense_Mutation_p.G55V|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_Missense_Mutation_p.G55V|GRIA2_uc011ciy.1_Missense_Mutation_p.G55V|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	745	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	ATGAAAGTTGGTGGAAACCTG	0.438													14	56					2.31682e-05	4.60839e-05	1	0	T	158281238	T	T	158281238	3	4	234	1	0	0	0	0	1	0	0	0	6807	1261	44	4	2284	4	GRIA2	4	158281238	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	36323275	158281238	32873038	89	42301											
FSTL5	56884	broad.mit.edu	37	chr4	162380450	162380450	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtcatagtgtaatttaactgGgacagggtctgtgctcactg	9	13	12	7	0	3	0	2	0	1	0	3	1	3	1	0	2	2	2	0	2	3	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:162380450G>C	uc003iqh.2	-	14	2066	c.1630C>G	c.(1630-1632)CCA>GCA	p.P544A	FSTL5_uc003iqi.2_Missense_Mutation_p.P543A|FSTL5_uc010iqv.2_Missense_Mutation_p.P534A	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	544						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		AATTTAACTGGGACAGGGTCT	0.378													10	56					0	0	0	0	C	162380450	C	C	162380450	3	2	234	1	0	0	0	0	1	0	0	0	6114	1232	43	4	925	4	FSTL5	4	162380450	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	4099212	162380450	28773826	90	42302											
TKTL2	84076	broad.mit.edu	37	chr4	164393884	164393884	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacaataactctttcatttgCacggcccagtttagccagag	12	11	7	11	1	2	1	1	0	1	1	2	1	2	1	2	1	4	2	2	1	4	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:164393884C>A	uc003iqp.3	-	1	1164	c.1003G>T	c.(1003-1005)GCA>TCA	p.A335S		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	335						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ctttcatttgcacggcccagt	0.189													32	105					1.62565e-12	3.81583e-12	1	0	A	164393884	A	A	164393884	3	1	234	1	0	0	0	0	1	0	0	0	16002	710	25	4	881	4	TKTL2	4	164393884	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	2013434	164393884	26760392	91	42303											
CYP4V2	285440	broad.mit.edu	37	chr4	187120147	187120147	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcgaagaataaagatgccCtggctttggcttgatctctg	9	14	10	8	1	1	3	0	1	1	2	3	4	1	3	1	2	1	2	1	2	4	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:187120147C>T	uc003iyw.3	+	6	1015	c.711C>T	c.(709-711)CCC>CCT	p.P237P		NM_207352	NP_997235	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily v,	237					response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		TAAAGATGCCCTGGCTTTGGC	0.368													15	55					0	0	0	0	T	187120147	T	T	187120147	2	4	234	1	0	0	0	0	0	0	0	1	4209	668	24	4		4	CYP4V2	4	187120147	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	22726263	187120147	4034129	92	42304											
FAT1	2195	broad.mit.edu	37	chr4	187629394	187629394	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagtataaacccgaggcaTcagttcgtagtccaggtttt	11	11	10	9	2	1	1	1	0	0	1	3	2	2	1	2	2	1	5	2	2	4	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr4:187629394T>A	uc003izf.2	-	2	1776	c.1588A>T	c.(1588-1590)ATG>TTG	p.M530L	FAT1_uc010iso.1_Missense_Mutation_p.M530L	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	530	Extracellular (Potential).|Cadherin 4.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACCCGAGGCATCAGTTCGTAG	0.473										HNSCC(5;0.00058)			24	65					0	0	0	0	A	187629394	A	A	187629394	3	1	234	1	0	0	0	0	1	0	0	0	5721	1435	50	5	12282	5	FAT1	4	187629394	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	509247	187629394	3524882	93	42305											
CTNND2	1501	broad.mit.edu	37	chr5	11082934	11082934	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcctttctcttttcggaCagcggctcggatatatactg	7	13	10	11	3	1	0	0	0	1	0	4	2	1	2	1	4	2	1	1	4	3	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr5:11082934C>G	uc003jfa.1	-	16	2807	c.2662G>C	c.(2662-2664)GTC>CTC	p.V888L	CTNND2_uc010itt.2_Missense_Mutation_p.V797L|CTNND2_uc011cmy.1_Missense_Mutation_p.V551L|CTNND2_uc011cmz.1_Missense_Mutation_p.V455L|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.V480L	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	888	ARM 8.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TCTTTTCGGACAGCGGCTCGG	0.532													30	22					0	0	0	0	G	11082934	G	G	11082934	3	3	234	1	0	0	0	0	1	0	0	0	4037	478	17	4	1043	4	CTNND2	5	11082934	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08		11082934	169832326	94	42306											
FGF10	2255	broad.mit.edu	37	chr5	44310549	44310549	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagccatagagtttcccctTcttgttcatggctaagtaat	9	15	8	9	0	2	2	1	1	1	1	3	2	3	2	3	1	1	4	3	1	3	7	rs104893887		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr5:44310549T>C	uc003jog.1	-	2	409	c.409A>G	c.(409-411)AAG>GAG	p.K137E		NM_004465	NP_004456	O15520	FGF10_HUMAN	fibroblast growth factor 10 precursor	137					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			lung(3)	3	Lung NSC(6;1.12e-06)					AGTTTCCCCTTCTTGTTCATG	0.388													9	38					0	0	0	0	C	44310549	C	C	44310549	3	2	234	1	0	0	0	0	1	0	0	0	5871	1792	62	5	225	5	FGF10	5	44310549	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	33227615	44310549	136604711	95	42307											
NLN	57486	broad.mit.edu	37	chr5	65118660	65118660	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacctgggggatctctggacGgcatggacatgctccacaat	10	8	12	11	1	1	0	0	0	1	0	3	3	2	3	2	5	2	2	2	5	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr5:65118660G>T	uc003juf.2	+	13	2148	c.2032G>T	c.(2032-2034)GGC>TGC	p.G678C	NLN_uc003jug.2_Missense_Mutation_p.G507C|NLN_uc010iww.2_Missense_Mutation_p.G355C	NM_020726	NP_065777	Q9BYT8	NEUL_HUMAN	neurolysin precursor	678					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		ATCTCTGGACGGCATGGACAT	0.413													28	42					7.26314e-15	1.75566e-14	1	0	T	65118660	T	T	65118660	3	4	234	1	0	0	0	0	1	0	0	0	10521	1116	39	3	2082	3	NLN	5	65118660	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	20808111	65118660	115796600	96	42308											
CAMK4	814	broad.mit.edu	37	chr5	110819999	110819999	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccccaaaatggtgcccaaGgcagtggaggatgggataaa	13	5	14	9	0	0	0	0	0	0	0	0	3	0	3	3	5	1	1	3	5	5	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr5:110819999G>A	uc011cvj.1	+	12	1356	c.1257G>A	c.(1255-1257)AAG>AAA	p.K419K	CAMK4_uc003kpf.2_Silent_p.K419K|CAMK4_uc010jbv.2_Silent_p.K222K|CAMK4_uc003kpg.2_Silent_p.K110K	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	419					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		TGGTGCCCAAGGCAGTGGAGG	0.537													15	35					0	0	0	0	A	110819999	A	A	110819999	2	1	234	1	0	0	0	0	0	0	0	1	2617	991	35	4		4	CAMK4	5	110819999	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	45701339	110819999	70095261	97	42309											
PCDHA1	56147	broad.mit.edu	37	chr5	140168241	140168241	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagaaagaaatgaacaacCagaagcaaatttggatcttt	18	9	8	6	0	2	4	1	1	1	3	2	5	2	5	1	1	3	1	1	1	6	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr5:140168241C>G	uc003lhb.2	+	1	2366	c.2366C>G	c.(2365-2367)CCA>CGA	p.P789R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.P789R	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	789	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGAACAACCAGAAGCAAAT	0.413													5	13					0	0	0	0	G	140168241	G	G	140168241	3	3	234	1	0	0	0	0	1	0	0	0	11573	594	21	4	2368	4	PCDHA1	5	140168241	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	29348242	140168241	40747019	98	42310											
PCDHA6	56142	broad.mit.edu	37	chr5	140207985	140207985	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggcggagcgcggagtgcagCatccacctggaggtgatcgt	7	6	18	10	4	0	1	0	1	0	0	2	4	1	4	2	5	3	2	2	5	0	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr5:140207985C>T	uc003lho.2	+	1	336	c.309C>T	c.(307-309)AGC>AGT	p.S103S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.S103S|PCDHA6_uc011dab.1_Silent_p.S103S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	103	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGAGTGCAGCATCCACCTGG	0.587													58	152					0	0	0	0	T	140207985	T	T	140207985	2	4	234	1	0	0	0	0	0	0	0	1	11582	709	25	4		4	PCDHA6	5	140207985	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	39744	140207985	40707275	99	42311											
PCDHAC2	56134	broad.mit.edu	37	chr5	140346945	140346945	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttcgagctggaccttaaGcccctgcaggagaacagtaa	12	7	10	12	1	0	1	0	0	0	1	1	4	0	2	3	2	4	3	3	2	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr5:140346945G>A	uc003lii.2	+	1	834	c.594G>A	c.(592-594)AAG>AAA	p.K198K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Silent_p.K198K	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	198	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACCTTAAGCCCCTGCAGG	0.612													5	16					0	0	0	0	A	140346945	A	A	140346945	2	1	234	1	0	0	0	0	0	0	0	1	11587	962	34	4		4	PCDHAC2	5	140346945	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	138960	140346945	40568315	100	42312											
PCDHGA2	56113	broad.mit.edu	37	chr5	140719217	140719217	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgctatctggcacctccCgcatctgcgtgaaggtcctg	6	10	11	14	2	2	1	0	1	2	0	4	1	4	1	3	2	2	3	3	2	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr5:140719217C>T	uc003ljk.1	+	1	864	c.679C>T	c.(679-681)CGC>TGC	p.R227C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.R227C	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	227	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCACCTCCCGCATCTGCGT	0.597													14	47					0	0	0	0	T	140719217	T	T	140719217	3	4	234	1	0	0	0	0	1	0	0	0	11608	652	23	1	681	1	PCDHGA2	5	140719217	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	372272	140719217	40196043	101	42313											
SH3TC2	79628	broad.mit.edu	37	chr5	148407522	148407522	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agggcacctgccttttccaaCagggcggagcctttatgtct	7	11	11	12	1	1	0	0	0	1	0	2	1	2	1	4	3	3	1	4	3	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr5:148407522C>A	uc003lpu.2	-	11	1925	c.1773G>T	c.(1771-1773)CTG>CTT	p.L591L	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Silent_p.L235L|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Silent_p.L138L|SH3TC2_uc010jgx.2_Silent_p.L584L|SH3TC2_uc003lpv.1_Silent_p.L138L|SH3TC2_uc011dbz.1_Silent_p.L476L	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	591							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTTTTCCAACAGGGCGGAGC	0.562													20	37					1.64113e-05	3.2733e-05	1	0	A	148407522	A	A	148407522	2	1	234	1	0	0	0	0	0	0	0	1	14327	465	17	4		4	SH3TC2	5	148407522	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	7688305	148407522	32507738	102	42314											
NSD1	64324	broad.mit.edu	37	chr5	176710803	176710803	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctaggaccgaatcattgatGctggtcccaaaggaaactat	13	10	9	9	1	2	1	1	1	1	0	3	4	3	3	2	3	2	1	2	3	5	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr5:176710803G>A	uc003mfr.3	+	20	6163	c.6025G>A	c.(6025-6027)GCT>ACT	p.A2009T	NSD1_uc003mft.3_Missense_Mutation_p.A1740T|NSD1_uc011dfx.1_Missense_Mutation_p.A1657T	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2009	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AATCATTGATGCTGGTCCCAA	0.443			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			26	72					0	0	0	0	A	176710803	A	A	176710803	3	1	234	1	0	0	0	0	1	0	0	0	10723	1319	46	4	6099	4	NSD1	5	176710803	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	28303281	176710803	4204457	103	42315											
TMEM170B	100113407	broad.mit.edu	37	chr6	11565999	11565999	+	Frame_Shift_Del	DEL	G	-	-																															atgctgcagaggcataggcaGggaagagtcatctctgtcat																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:11565999delG	uc010jpa.2	+	2	198	c.198delG	c.(196-198)CAGfs	p.Q66fs		NM_001100829	NP_001094299	Q5T4T1	T170B_HUMAN	transmembrane protein 170B	66	Cytoplasmic (Potential).					integral to membrane					0						GGCATAGGCAGGGAAGAGTCA	0.463													---	---	---								-	11565999	-	-	11565999	7	5	234	1	0	1	0	1	0	0	0	0	16153	991	35	0	204	0	TMEM170B	6	11565999	Frame_Shift_Del	DEL	G	TCGA-CV-7242-01A-11D-2012-08		11565999	159549068	104	42316											
OR2B2	81697	broad.mit.edu	37	chr6	27879226	27879226	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttacctctttgttcctaagtGtatatataaggggattcagc	10	16	8	7	0	2	0	1	0	1	0	3	1	3	1	2	2	2	2	2	2	6	9			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:27879226G>A	uc011dkw.1	-	1	872	c.872C>T	c.(871-873)ACA>ATA	p.T291I		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	291	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTTCCTAAGTGTATATATAAG	0.398													10	44					0	0	0	0	A	27879226	A	A	27879226	3	1	234	1	0	0	0	0	1	0	0	0	11043	1377	48	4	205	4	OR2B2	6	27879226	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	16313227	27879226	143235841	105	42317											
SCAND3	114821	broad.mit.edu	37	chr6	28543800	28543800	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtaaccttgctaagcttcTgaagaacttttctctcatgt	10	15	6	10	0	3	2	1	1	2	1	4	2	3	2	1	0	4	3	1	0	4	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:28543800T>A	uc003nlo.2	-	3	1300	c.682A>T	c.(682-684)AGA>TGA	p.R228*		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	228					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCTAAGCTTCTGAAGAACTTT	0.348													8	50					0	0	0	0	A	28543800	A	A	28543800	4	1	234	1	0	0	0	0	0	1	0	0	13941	1588	55	5	3303	5	SCAND3	6	28543800	Nonsense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	664574	28543800	142571267	106	42318											
HLA-DPA1	3113	broad.mit.edu	37	chr6	33041402	33041402	+	5'Flank	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaacagtgatgaggaactgAggccgagtggaggcagatga	13	5	18	5	1	0	5	0	4	0	1	0	9	0	8	1	5	2	1	1	5	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:33041402A>T	uc003ocs.1	-						HLA-DPA1_uc010juk.2_5'UTR|HLA-DPA1_uc003oct.1_5'UTR|HLA-DPB1_uc011dqn.1_5'Flank|HLA-DPB1_uc003ocu.1_5'Flank|HLA-DPB1_uc011dqo.1_5'Flank|HLA-DPB1_uc011dqp.1_5'Flank	NM_033554	NP_291032	P20036	DPA1_HUMAN	major histocompatibility complex, class II, DP						antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			skin(1)	1						TGAGGAACTGAGGCCGAGTGG	0.493													12	24					0	0	0	0	T	33041402	T	T	33041402	1	4	234	0	1	0	0	0	0	0	0	0	7241	319	11	5		5	HLA-DPA1	6	33041402	5'Flank	SNP	A	TCGA-CV-7242-01A-11D-2012-08	4497602	33041402	138073665	107	42319											
C6orf222	389384	broad.mit.edu	37	chr6	36294357	36294357	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aagctggacttcttgggtggCcaggcctctggactggaaac	8	9	14	10	0	2	0	0	0	2	0	2	3	2	3	2	6	2	1	2	6	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:36294357C>T	uc003oly.2	-	5	1144	c.966G>A	c.(964-966)TGG>TGA	p.W322*		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	322										skin(2)|ovary(1)|breast(1)	4						TCTTGGGTGGCCAGGCCTCTG	0.572													16	100					0	0	0	0	T	36294357	T	T	36294357	4	4	234	1	0	0	0	0	0	1	0	0	2366	740	26	4	1024	4	C6orf222	6	36294357	Nonsense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	3252955	36294357	134820710	108	42320											
DNAH8	1769	broad.mit.edu	37	chr6	38854730	38854730	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgtttaaaaagacaatttaCtgtgtttaattgtacattgc	14	16	6	5	1	0	1	0	0	0	1	0	1	0	1	0	0	3	3	0	0	7	9			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:38854730C>A	uc003ooe.1	+	55	8372	c.7772C>A	c.(7771-7773)ACT>AAT	p.T2591N		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGACAATTTACTGTGTTTAAT	0.338													12	25					4.36969e-10	9.78489e-10	1	0	A	38854730	A	A	38854730	3	1	234	1	0	0	0	0	1	0	0	0	4629	565	20	4	7982	4	DNAH8	6	38854730	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	2560373	38854730	132260337	109	42321											
POLH	5429	broad.mit.edu	37	chr6	43581937	43581937	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagcaactcctgcagagatGgatttggcccacaacagcca	14	6	9	12	0	0	1	0	0	0	1	1	3	1	2	3	2	5	2	3	2	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:43581937G>T	uc003ovq.3	+	11	2089	c.1785G>T	c.(1783-1785)ATG>ATT	p.M595I	POLH_uc010jyu.2_Missense_Mutation_p.M471I|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_Missense_Mutation_p.M496I	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	595					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			CTGCAGAGATGGATTTGGCCC	0.488								DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum				12	53					1.61879e-10	3.69287e-10	1	0	T	43581937	T	T	43581937	3	4	234	1	0	0	0	0	1	0	0	0	12257	1348	47	4	1823	4	POLH	6	43581937	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	4727207	43581937	127533130	110	42322											
PHF3	23469	broad.mit.edu	37	chr6	64422632	64422632	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttcagcagagtgacaatttAaaagttgcacaaaactcacc	16	9	7	9	0	2	2	2	1	0	1	2	2	2	2	1	0	3	4	1	0	5	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:64422632A>T	uc003pep.1	+	15	5174	c.5148A>T	c.(5146-5148)TTA>TTT	p.L1716F	PHF3_uc003pen.2_Missense_Mutation_p.L1628F|PHF3_uc011dxs.1_Missense_Mutation_p.L985F	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1716					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			GTGACAATTTAAAAGTTGCAC	0.373													9	27					0	0	0	0	T	64422632	T	T	64422632	3	4	234	1	0	0	0	0	1	0	0	0	11891	359	13	5	5206	5	PHF3	6	64422632	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	20840695	64422632	106692435	111	42323											
COL19A1	1310	broad.mit.edu	37	chr6	70861308	70861308	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gattgcacttcctctcttggGagacatcggtgctttgctca	6	14	10	11	1	2	1	1	0	1	1	5	3	3	1	1	2	3	3	1	2	0	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:70861308G>C	uc003pfc.1	+	31	2174	c.2057G>C	c.(2056-2058)GGA>GCA	p.G686A	COL19A1_uc010kam.1_Missense_Mutation_p.G582A	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	686	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						CCTCTCTTGGGAGACATCGGT	0.308													16	64					0	0	0	0	C	70861308	C	C	70861308	3	2	234	1	0	0	0	0	1	0	0	0	3691	1174	41	2	2175	2	COL19A1	6	70861308	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	6438676	70861308	100253759	112	42324											
SNAP91	9892	broad.mit.edu	37	chr6	84375158	84375158	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaagtttacttagtttacCtcatttccatgcaccatgag	12	14	6	9	0	1	1	1	1	0	0	2	2	2	1	3	0	3	3	3	0	5	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:84375158C>A	uc011dze.1	-	3	590	c.273G>T	c.(271-273)GAG>GAT	p.E91D	SNAP91_uc003pkb.2_Missense_Mutation_p.E56D|SNAP91_uc003pkc.2_Missense_Mutation_p.E91D|SNAP91_uc003pkd.2_Missense_Mutation_p.E91D|SNAP91_uc003pka.2_Missense_Mutation_p.E91D|SNAP91_uc011dzf.1_Intron	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	91	ENTH.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		CTTAGTTTACCTCATTTCCAT	0.408													53	136					2.84144e-21	7.35549e-21	1	0	A	84375158	A	A	84375158	3	1	234	1	0	0	0	0	1	0	0	0	14897	695	24	4	2554	4	SNAP91	6	84375158	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	13513850	84375158	86739909	113	42325											
HTR1E	3354	broad.mit.edu	37	chr6	87725251	87725251	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatctgttctctggccgtgAcggacctcctggtggcagtg	5	12	13	11	2	2	1	0	1	2	0	4	2	3	2	3	4	0	2	3	4	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:87725251A>G	uc003pli.2	+	2	902	c.199A>G	c.(199-201)ACG>GCG	p.T67A		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	67	Helical; Name=2; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TCTGGCCGTGACGGACCTCCT	0.557													29	83					0	0	0	0	G	87725251	G	G	87725251	3	3	234	1	0	0	0	0	1	0	0	0	7478	275	10	5	201	5	HTR1E	6	87725251	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	3350093	87725251	83389816	114	42326											
CASP8AP2	9994	broad.mit.edu	37	chr6	90572117	90572117	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taatggtgtttggtcacgttCtcattatcaggttggcgagg	7	15	13	6	2	3	0	3	0	1	0	4	1	3	0	0	5	0	3	0	5	2	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:90572117C>G	uc003pnr.2	+	7	885	c.689C>G	c.(688-690)TCT>TGT	p.S230C	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.S230C|CASP8AP2_uc011dzz.1_Missense_Mutation_p.S230C	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	230					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TGGTCACGTTCTCATTATCAG	0.393													72	173					0	0	0	0	G	90572117	G	G	90572117	3	3	234	1	0	0	0	0	1	0	0	0	2690	913	32	2	711	2	CASP8AP2	6	90572117	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	2846866	90572117	80542950	115	42327											
FUT9	10690	broad.mit.edu	37	chr6	96652001	96652001	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actggaggaaggatttcactGtaaatcttccacgattttgg	11	13	10	7	1	2	0	1	0	1	0	3	4	3	3	1	4	0	1	1	4	3	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:96652001G>C	uc003pop.3	+	3	1311	c.970G>C	c.(970-972)GTA>CTA	p.V324L		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	324	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GGATTTCACTGTAAATCTTCC	0.363													15	29					0	0	0	0	C	96652001	C	C	96652001	3	2	234	1	0	0	0	0	1	0	0	0	6145	1377	48	4	972	4	FUT9	6	96652001	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	6079884	96652001	74463066	116	42328											
LAMA2	3908	broad.mit.edu	37	chr6	129802530	129802530	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtccggcatcattcttttGggaagtggagggacaccagc	9	9	14	9	1	2	0	1	0	1	0	3	4	3	3	2	4	1	1	2	4	1	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:129802530G>A	uc003qbn.2	+	54	7800	c.7695G>A	c.(7693-7695)TTG>TTA	p.L2565L	LAMA2_uc003qbo.2_Silent_p.L2561L|uc003qbq.2_RNA	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2565	Laminin G-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCATTCTTTTGGGAAGTGGAG	0.478													13	66					0	0	0	0	A	129802530	A	A	129802530	2	1	234	1	0	0	0	0	0	0	0	1	8646	1339	47	4		4	LAMA2	6	129802530	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	33150529	129802530	41312537	117	42329											
VNN1	8876	broad.mit.edu	37	chr6	133013716	133013716	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaattgggtgcatagatGccacttcctggaagtaataa	14	10	11	6	0	0	2	0	0	0	2	1	4	1	3	2	2	2	2	2	2	6	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:133013716G>T	uc003qdo.2	-	5	854	c.834C>A	c.(832-834)GGC>GGA	p.G278G		NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	278	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		GTGCATAGATGCCACTTCCTG	0.358													9	20					1.58986e-06	3.27853e-06	1	0	T	133013716	T	T	133013716	2	4	234	1	0	0	0	0	0	0	0	1	17250	1306	46	4		4	VNN1	6	133013716	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	3211186	133013716	38101351	118	42330											
AHI1	54806	broad.mit.edu	37	chr6	135639745	135639745	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatctcaggaggcagttctTgatacagtgctgaaattgga	11	13	11	6	0	2	2	1	2	2	0	3	4	2	4	0	3	2	3	0	3	3	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:135639745T>G	uc003qgi.2	-	26	3722	c.3338A>C	c.(3337-3339)CAA>CCA	p.Q1113P	AHI1_uc003qgf.2_RNA|AHI1_uc003qgg.2_Missense_Mutation_p.Q563P|AHI1_uc003qgh.2_Missense_Mutation_p.Q1113P|AHI1_uc003qgj.2_Missense_Mutation_p.Q1113P|AHI1_uc003qgk.3_RNA	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	1113						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		AGGCAGTTCTTGATACAGTGC	0.393													3	9					0	0	0	0	G	135639745	G	G	135639745	3	3	234	1	0	0	0	0	1	0	0	0	413	1812	63	5	268	5	AHI1	6	135639745	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	2626029	135639745	35475322	119	42331											
BCLAF1	9774	broad.mit.edu	37	chr6	136590672	136590672	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagcccttggaatctccccGttctttacttctttcttttc	4	18	6	13	1	4	0	0	0	4	0	6	2	4	2	3	2	2	1	3	2	2	8	rs140624845		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:136590672G>C	uc003qgx.1	-	9	2375	c.2122C>G	c.(2122-2124)CGG>GGG	p.R708G	BCLAF1_uc011edb.1_5'Flank|BCLAF1_uc003qgw.1_Missense_Mutation_p.R535G|BCLAF1_uc003qgy.1_Missense_Mutation_p.R706G|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R706G	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	708					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GAATCTCCCCGTTCTTTACTT	0.388													10	74					0	0	0	0	C	136590672	C	C	136590672	3	2	234	1	0	0	0	0	1	0	0	0	1385	1144	40	3	660	3	BCLAF1	6	136590672	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	950927	136590672	34524395	120	42332											
SHPRH	257218	broad.mit.edu	37	chr6	146262922	146262922	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgacataatttaattctgaaCgcagtacatcataggtaatg	15	12	7	7	2	2	1	1	1	1	0	2	2	2	1	0	1	2	3	0	1	6	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:146262922C>A	uc003qlf.2	-	10	2726	c.2327G>T	c.(2326-2328)CGT>CTT	p.R776L	SHPRH_uc003qld.2_Missense_Mutation_p.R776L|SHPRH_uc003qle.2_Missense_Mutation_p.R776L|SHPRH_uc003qlg.1_Missense_Mutation_p.R332L|SHPRH_uc003qlj.1_Missense_Mutation_p.R665L	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	776	Helicase ATP-binding; second part.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TAATTCTGAACGCAGTACATC	0.418													6	50					8.12818e-05	0.000159077	1	0	A	146262922	A	A	146262922	3	1	234	1	0	0	0	0	1	0	0	0	14356	536	19	3	2852	3	SHPRH	6	146262922	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	9672250	146262922	24852145	121	42333											
SHPRH	257218	broad.mit.edu	37	chr6	146263002	146263002	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagccatctttcttcactccTtgatatacctaggaaataat	13	14	4	10	0	3	1	1	1	2	0	4	2	4	2	3	1	2	0	3	1	6	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:146263002T>G	uc003qlf.2	-	10	2646	c.2247A>C	c.(2245-2247)CAA>CAC	p.Q749H	SHPRH_uc003qld.2_Missense_Mutation_p.Q749H|SHPRH_uc003qle.2_Missense_Mutation_p.Q749H|SHPRH_uc003qlg.1_Missense_Mutation_p.Q305H|SHPRH_uc003qlj.1_Missense_Mutation_p.Q638H	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	749	Helicase ATP-binding; second part.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TCTTCACTCCTTGATATACCT	0.343													3	30					0	0	0	0	G	146263002	G	G	146263002	3	3	234	1	0	0	0	0	1	0	0	0	14356	1606	56	5	2932	5	SHPRH	6	146263002	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	80	146263002	24852065	122	42334											
GRM1	2911	broad.mit.edu	37	chr6	146720036	146720036	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgtactgtaccgggacacaCcagtggtcaaatcctccagt	10	10	9	12	1	1	0	1	0	0	0	3	1	3	1	4	2	2	2	4	2	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:146720036C>A	uc010khw.1	+	8	2331	c.1861C>A	c.(1861-1863)CCA>ACA	p.P621T	GRM1_uc010khv.1_Missense_Mutation_p.P621T|GRM1_uc003qll.2_Missense_Mutation_p.P621T|GRM1_uc011edz.1_Missense_Mutation_p.P621T|GRM1_uc011eea.1_Missense_Mutation_p.P621T	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	621	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCGGGACACACCAGTGGTCAA	0.483													42	195					2.40579e-17	6.01448e-17	1	0	A	146720036	A	A	146720036	3	1	234	1	0	0	0	0	1	0	0	0	6835	507	18	4	1887	4	GRM1	6	146720036	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	457034	146720036	24395031	123	42335											
AKAP12	9590	broad.mit.edu	37	chr6	151673477	151673477	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagctgaatgtaaaaaggaTgatgctcttgaactgcagag	15	9	12	5	0	1	4	0	3	1	1	1	6	1	5	0	1	4	4	0	1	6	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr6:151673477T>A	uc011eep.1	+	4	4191	c.3951T>A	c.(3949-3951)GAT>GAA	p.D1317E	AKAP12_uc003qoe.2_Missense_Mutation_p.D1317E|AKAP12_uc003qof.2_Missense_Mutation_p.D1219E|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.D1212E	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1317					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GTAAAAAGGATGATGCTCTTG	0.478													23	77					0	0	0	0	A	151673477	A	A	151673477	3	1	234	1	0	0	0	0	1	0	0	0	448	1461	51	5	3990	5	AKAP12	6	151673477	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	4953441	151673477	19441590	124	42336											
INTS1	26173	broad.mit.edu	37	chr7	1515969	1515969	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcaggggcagccgggcctgGatgaggctgcaggcggctgt	6	5	20	10	2	0	1	0	1	0	0	0	2	0	2	2	7	3	5	2	7	0	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:1515969G>A	uc003skn.2	-	38	5375	c.5274C>T	c.(5272-5274)ATC>ATT	p.I1758I	INTS1_uc003skm.1_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1758					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GCCGGGCCTGGATGAGGCTGC	0.687													4	6					0	0	0	0	A	1515969	A	A	1515969	2	1	234	1	0	0	0	0	0	0	0	1	7814	1164	41	2		2	INTS1	7	1515969	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08		1515969	157622694	125	42337											
SFRP4	6424	broad.mit.edu	37	chr7	37953821	37953821	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagacgacttaccatagcTgtagtttttgctgagatacg	12	12	9	8	2	0	2	0	1	0	2	0	4	0	2	1	0	5	4	1	0	5	6	rs112054297		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:37953821T>C	uc003tfo.3	-	3	972	c.586A>G	c.(586-588)AGC>GGC	p.S196G		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	196	NTR.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						TTACCATAGCTGTAGTTTTTG	0.398													16	32					0	0	0	0	C	37953821	C	C	37953821	3	2	234	1	0	0	0	0	1	0	0	0	14228	1580	55	5	470	5	SFRP4	7	37953821	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	36437852	37953821	121184842	126	42338											
ABCB4	5244	broad.mit.edu	37	chr7	87053332	87053332	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgttttattcagtttcaGgaccttcagaaaggacactg	10	15	8	8	0	4	1	3	0	1	1	4	3	4	3	1	2	0	2	1	2	2	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:87053332G>T	uc003uiv.1	-	17	2177	c.2101C>A	c.(2101-2103)CTG>ATG	p.L701M	ABCB4_uc003uiw.1_Missense_Mutation_p.L701M|ABCB4_uc003uix.1_Missense_Mutation_p.L701M	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	701	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTCAGTTTCAGGACCTTCAGA	0.413													20	73					5.03518e-11	1.15588e-10	1	0	T	87053332	T	T	87053332	3	4	234	1	0	0	0	0	1	0	0	0	43	991	35	4	1807	4	ABCB4	7	87053332	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	49099511	87053332	72085331	127	42339											
ZNF804B	219578	broad.mit.edu	37	chr7	88966279	88966279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agatttttgccatcattcttGctctagccagatgcaacagc	10	13	7	11	0	3	2	1	0	2	2	3	2	3	2	2	0	6	2	2	0	2	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:88966279G>A	uc011khi.1	+	4	4521	c.3983G>A	c.(3982-3984)TGC>TAC	p.C1328Y		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1328						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CATCATTCTTGCTCTAGCCAG	0.393										HNSCC(36;0.09)			16	58					0	0	0	0	A	88966279	A	A	88966279	3	1	234	1	0	0	0	0	1	0	0	0	18238	1319	46	4	3997	4	ZNF804B	7	88966279	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	1912947	88966279	70172384	128	42340											
CLDN12	9069	broad.mit.edu	37	chr7	90042423	90042423	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctatttttcctggcaggtActgtgagcctctccccatct	5	15	8	13	0	2	1	0	1	2	0	4	1	3	1	4	2	3	3	4	2	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:90042423A>T	uc003ukp.2	+	5	1069	c.433A>T	c.(433-435)ACT>TCT	p.T145S	CLDN12_uc003ukq.2_Missense_Mutation_p.T145S|CLDN12_uc010leq.2_Missense_Mutation_p.T145S|CLDN12_uc003ukr.2_Missense_Mutation_p.T145S|CLDN12_uc003uks.2_Missense_Mutation_p.T145S	NM_012129	NP_036261	P56749	CLD12_HUMAN	claudin 12	145	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						CCTGGCAGGTACTGTGAGCCT	0.488													10	110					0	0	0	0	T	90042423	T	T	90042423	3	4	234	1	0	0	0	0	1	0	0	0	3489	391	14	5	435	5	CLDN12	7	90042423	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	1076144	90042423	69096240	129	42341											
AKAP9	10142	broad.mit.edu	37	chr7	91724387	91724387	+	Nonsense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatttgcttaatgacacatTagcaagtgaacagaaaaaat	19	10	6	6	0	0	3	0	2	0	1	0	3	0	3	0	0	3	2	0	0	7	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:91724387T>G	uc003ulg.2	+	40	9854	c.9629T>G	c.(9628-9630)TTA>TGA	p.L3210*	AKAP9_uc003ulf.2_Nonsense_Mutation_p.L3202*|AKAP9_uc003uli.2_Nonsense_Mutation_p.L2833*|AKAP9_uc003ulj.2_Nonsense_Mutation_p.L980*|AKAP9_uc003ull.2_Nonsense_Mutation_p.L106*	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3214	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AATGACACATTAGCAAGTGAA	0.388			T	BRAF	papillary thyroid								4	45					0	0	0	0	G	91724387	G	G	91724387	4	3	234	1	0	0	0	0	0	1	0	0	459	1764	61	5	9787	5	AKAP9	7	91724387	Nonsense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	1681964	91724387	67414276	130	42342											
SGCE	8910	broad.mit.edu	37	chr7	94259126	94259126	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgggtatacattccgatcgGagtgtaccttggagaaaata	13	11	11	6	2	0	1	0	0	0	1	2	4	1	2	2	3	2	2	2	3	6	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:94259126G>T	uc003unl.2	-	2	248	c.137C>A	c.(136-138)TCC>TAC	p.S46Y	SGCE_uc003unm.2_Missense_Mutation_p.S46Y|SGCE_uc003unn.2_Missense_Mutation_p.S46Y|SGCE_uc011kic.1_Intron|SGCE_uc011kid.1_Missense_Mutation_p.S82Y	NM_003919	NP_003910	O43556	SGCE_HUMAN	sarcoglycan, epsilon isoform 2	46	Extracellular (Potential).				cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			ATTCCGATCGGAGTGTACCTT	0.398													10	81					0.000442599	0.000845805	1	0	T	94259126	T	T	94259126	3	4	234	1	0	0	0	0	1	0	0	0	14267	1174	41	2	1368	2	SGCE	7	94259126	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2534739	94259126	64879537	131	42343											
CYP3A4	1576	broad.mit.edu	37	chr7	99358513	99358513	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaagtttcatgttcatgaGagcaaacctcatgccaatgc	13	10	8	10	0	3	1	3	1	0	1	3	2	3	1	2	0	5	4	2	0	3	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:99358513G>T	uc003urv.1	-	12	1449	c.1345C>A	c.(1345-1347)CTC>ATC	p.L449I	CYP3A4_uc003urw.1_Missense_Mutation_p.L448I|CYP3A4_uc011kiz.1_Missense_Mutation_p.L408I|CYP3A4_uc011kja.1_Missense_Mutation_p.L400I|CYP3A4_uc011kjb.1_Missense_Mutation_p.L299I	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	449					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	ATGTTCATGAGAGCAAACCTC	0.383													36	85					6.05902e-23	1.58533e-22	1	0	T	99358513	T	T	99358513	3	4	234	1	0	0	0	0	1	0	0	0	4195	942	33	2	174	2	CYP3A4	7	99358513	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	5099387	99358513	59780150	132	42344											
RELN	5649	broad.mit.edu	37	chr7	103270558	103270558	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctctgggaagaatgatacGgttgccaccatctgaactga	11	10	10	10	1	2	4	0	3	2	1	3	5	2	5	2	2	3	1	2	2	4	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:103270558G>C	uc003vca.2	-	20	2691	c.2531C>G	c.(2530-2532)CCG>CGG	p.P844R	RELN_uc010liz.2_Missense_Mutation_p.P844R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	844					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGAATGATACGGTTGCCACCA	0.363													11	69					0	0	0	0	C	103270558	C	C	103270558	3	2	234	1	0	0	0	0	1	0	0	0	13285	1116	39	3	8035	3	RELN	7	103270558	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	3912045	103270558	55868105	133	42345											
AASS	10157	broad.mit.edu	37	chr7	121756934	121756934	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatctcctgtcccttaccTccagtttgggaaacttcttt	6	16	6	13	0	3	0	1	0	2	0	6	1	5	1	4	1	2	1	4	1	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:121756934T>A	uc003vka.2	-	6	861	c.765A>T	c.(763-765)GGA>GGT	p.G255G	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Silent_p.G255G|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	255	Lysine-ketoglutarate reductase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	GTCCCTTACCTCCAGTTTGGG	0.328													31	70					0	0	0	0	A	121756934	A	A	121756934	2	1	234	1	0	0	0	0	0	0	0	1	24	1565	54	5		5	AASS	7	121756934	Silent	SNP	T	TCGA-CV-7242-01A-11D-2012-08	18486376	121756934	37381729	134	42346											
CADPS2	93664	broad.mit.edu	37	chr7	122221318	122221318	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccacaggccgaggatgggtgGtggtgaaatctccttgagtc	8	9	15	9	1	1	2	0	2	1	0	3	4	1	3	3	5	0	0	3	5	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:122221318G>T	uc010lkp.2	-	7	1413	c.1250C>A	c.(1249-1251)ACC>AAC	p.T417N	CADPS2_uc003vkg.3_Missense_Mutation_p.T117N|CADPS2_uc010lkq.2_Missense_Mutation_p.T417N	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	417	C2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						AGGATGGGTGGTGGTGAAATC	0.443													16	101					3.41278e-10	7.66563e-10	1	0	T	122221318	T	T	122221318	3	4	234	1	0	0	0	0	1	0	0	0	2583	1261	44	4	2780	4	CADPS2	7	122221318	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	464384	122221318	36917345	135	42347											
IQUB	154865	broad.mit.edu	37	chr7	123143292	123143292	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agttatgatttgagagacatCagttaatccatctattcttc	12	16	6	7	0	3	3	1	2	2	1	5	4	4	3	1	0	0	2	1	0	3	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:123143292C>G	uc003vkn.2	-	4	1235	c.658G>C	c.(658-660)GAT>CAT	p.D220H	IQUB_uc003vko.2_Missense_Mutation_p.D220H|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Missense_Mutation_p.D220H|IQUB_uc003vkq.2_Missense_Mutation_p.D220H	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	220										ovary(3)|large_intestine(1)	4						TGAGAGACATCAGTTAATCCA	0.358													25	84					0	0	0	0	G	123143292	G	G	123143292	3	3	234	1	0	0	0	0	1	0	0	0	7859	826	29	2	1757	2	IQUB	7	123143292	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	921974	123143292	35995371	136	42348											
CNTNAP2	26047	broad.mit.edu	37	chr7	146829568	146829568	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgttcacatcaacatcacaCagaccaagatgagccaaatc	16	7	6	12	0	3	3	3	1	0	2	4	3	3	3	2	0	2	1	2	0	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:146829568C>T	uc003weu.1	+	8	1831	c.1315C>T	c.(1315-1317)CAG>TAG	p.Q439*		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	439	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAACATCACACAGACCAAGAT	0.423										HNSCC(39;0.1)			4	32					0	0	0	0	T	146829568	T	T	146829568	4	4	234	1	0	0	0	0	0	1	0	0	3662	479	17	4	1345	4	CNTNAP2	7	146829568	Nonsense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	23686276	146829568	12309095	137	42349											
CRYGN	155051	broad.mit.edu	37	chr7	151127188	151127188	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgctggttttgtggtggcCtcttccggtccttgatctga	2	17	13	9	1	2	2	0	2	2	0	4	2	4	2	3	4	1	3	3	4	0	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:151127188C>G	uc003wke.2	-	4	591	c.495G>C	c.(493-495)GAG>GAC	p.E165D	CRYGN_uc003wkf.2_3'UTR|CRYGN_uc003wkg.2_RNA	NM_144727	NP_653328	Q8WXF5	CRGN_HUMAN	gammaN-crystallin	165											0			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTGTGGTGGCCTCTTCCGGTC	0.532													18	63					0	0	0	0	G	151127188	G	G	151127188	3	3	234	1	0	0	0	0	1	0	0	0	3933	680	24	4	57	4	CRYGN	7	151127188	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	4297620	151127188	8011475	138	42350											
GALNT11	63917	broad.mit.edu	37	chr7	151797963	151797963	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaatatgcttatcagtgacCgcttgggctaccacagagat	11	12	9	9	1	1	2	1	1	0	1	1	3	1	2	2	1	2	3	2	1	4	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:151797963C>T	uc010lqg.1	+	3	606	c.376C>T	c.(376-378)CGC>TGC	p.R126C	GALNT11_uc011kvm.1_Missense_Mutation_p.R45C|GALNT11_uc003wku.2_Missense_Mutation_p.R126C|GALNT11_uc003wkv.1_Missense_Mutation_p.R126C|GALNT11_uc011kvn.1_Intron	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	126	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		TATCAGTGACCGCTTGGGCTA	0.408													20	79					0	0	0	0	T	151797963	T	T	151797963	3	4	234	1	0	0	0	0	1	0	0	0	6244	652	23	1	382	1	GALNT11	7	151797963	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	670775	151797963	7340700	139	42351											
MLL3	58508	broad.mit.edu	37	chr7	151845956	151845956	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcttccatttcattcctctCcattttttattgagcggcct	5	20	4	12	1	3	1	1	1	2	0	6	1	5	1	4	1	1	0	4	1	1	8			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr7:151845956C>T	uc003wla.2	-	52	13275	c.13056G>A	c.(13054-13056)TGG>TGA	p.W4352*	MLL3_uc003wkz.2_Nonsense_Mutation_p.W3470*|MLL3_uc003wkx.2_Nonsense_Mutation_p.W510*|MLL3_uc003wky.2_Nonsense_Mutation_p.W1916*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4352					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCATTCCTCTCCATTTTTTAT	0.433			N		medulloblastoma								11	41					0	0	0	0	T	151845956	T	T	151845956	4	4	234	1	0	0	0	0	0	1	0	0	9675	856	30	2	1711	2	MLL3	7	151845956	Nonsense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	47993	151845956	7292707	140	42352											
CSMD1	64478	broad.mit.edu	37	chr8	2823313	2823313	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaacctttgcagacaggtttGctcggattccacctgccgtc	8	11	9	13	2	0	1	0	0	0	1	3	2	1	2	4	2	4	3	4	2	1	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr8:2823313G>T	uc011kwk.1	-	59	9657	c.9267C>A	c.(9265-9267)AGC>AGA	p.S3089R	CSMD1_uc011kwj.1_Missense_Mutation_p.S2418R|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3089	Extracellular (Potential).|Sushi 24.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGACAGGTTTGCTCGGATTCC	0.403													7	10					0.000274275	0.000526897	1	0	T	2823313	T	T	2823313	3	4	234	1	0	0	0	0	1	0	0	0	3961	1310	46	4	1478	4	CSMD1	8	2823313	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08		2823313	143540709	141	42353											
LZTS1	11178	broad.mit.edu	37	chr8	20107319	20107319	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccccggcgctgtccccacGtgccagctgctgcagggcct	3	7	12	19	3	0	0	0	0	0	0	2	0	2	0	6	2	4	4	6	2	0	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr8:20107319G>A	uc003wzr.2	-	3	1816	c.1705C>T	c.(1705-1707)CGT>TGT	p.R569C	LZTS1_uc010ltg.1_Missense_Mutation_p.R510C	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	569					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		CTGTCCCCACGTGCCAGCTGC	0.617													18	104					0	0	0	0	A	20107319	A	A	20107319	3	1	234	1	0	0	0	0	1	0	0	0	9189	1145	40	1	89	1	LZTS1	8	20107319	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	17284006	20107319	126256703	142	42354											
TEX15	56154	broad.mit.edu	37	chr8	30703870	30703870	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaacatctgcttccatcatcTattgttgtgacattagaagg	12	14	7	8	0	3	2	1	1	2	1	4	2	4	2	1	1	2	2	1	1	4	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr8:30703870T>C	uc003xil.2	-	1	2664	c.2664A>G	c.(2662-2664)ATA>ATG	p.I888M		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	888										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTCCATCATCTATTGTTGTGA	0.328													15	53					0	0	0	0	C	30703870	C	C	30703870	3	2	234	1	0	0	0	0	1	0	0	0	15845	1512	53	5	5721	5	TEX15	8	30703870	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	10596551	30703870	115660152	143	42355											
TACC1	6867	broad.mit.edu	37	chr8	38699961	38699961	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggtgttctggaagggttcaAgaaggtagagtgttttttcc	9	14	14	4	0	2	2	1	0	1	2	3	3	3	3	1	4	0	4	1	4	4	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr8:38699961A>C	uc010lwp.2	+	10	2496	c.2117A>C	c.(2116-2118)AAG>ACG	p.K706T	TACC1_uc003xma.2_Missense_Mutation_p.K144T|TACC1_uc003xlz.2_Missense_Mutation_p.K511T|TACC1_uc003xmc.3_Missense_Mutation_p.K510T|TACC1_uc011lbz.1_Missense_Mutation_p.K693T|TACC1_uc003xmb.3_Missense_Mutation_p.K632T|TACC1_uc003xmf.3_Missense_Mutation_p.K296T|TACC1_uc011lca.1_Missense_Mutation_p.K689T|TACC1_uc011lcb.1_Missense_Mutation_p.K482T|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_Missense_Mutation_p.K523T|TACC1_uc010lwq.2_Missense_Mutation_p.K522T	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	706	|Interaction with CH-TOG.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			GAAGGGTTCAAGAAGGTAGAG	0.453													24	63					0	0	0	0	C	38699961	C	C	38699961	3	2	234	1	0	0	0	0	1	0	0	0	15567	72	3	5	2155	5	TACC1	8	38699961	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	7996091	38699961	107664061	144	42356											
KIAA1429	25962	broad.mit.edu	37	chr8	95500951	95500951	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttttatcgtgtaaaggagcGtacatgacgacctctaccac	11	12	8	10	3	1	1	0	1	1	0	2	3	1	2	2	1	3	2	2	1	5	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr8:95500951G>A	uc003ygo.1	-	24	5435	c.5422C>T	c.(5422-5424)CGC>TGC	p.R1808C	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1808					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GTAAAGGAGCGTACATGACGA	0.438													28	77					0	0	0	0	A	95500951	A	A	95500951	3	1	234	1	0	0	0	0	1	0	0	0	8270	1145	40	1	20	1	KIAA1429	8	95500951	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	56800990	95500951	50863071	145	42357											
CSMD3	114788	broad.mit.edu	37	chr8	113353910	113353910	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaatttacaaactggagatGtacacctgaagaagaaaaca	21	7	7	6	0	0	4	0	1	0	3	0	5	0	4	1	1	4	1	1	1	9	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr8:113353910G>T	uc003ynu.2	-	42	6607	c.6448C>A	c.(6448-6450)CAT>AAT	p.H2150N	CSMD3_uc003yns.2_Missense_Mutation_p.H1352N|CSMD3_uc003ynt.2_Missense_Mutation_p.H2110N|CSMD3_uc011lhx.1_Missense_Mutation_p.H2046N	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2150	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AACTGGAGATGTACACCTGAA	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			20	14					5.03518e-11	1.15588e-10	1	0	T	113353910	T	T	113353910	3	4	234	1	0	0	0	0	1	0	0	0	3963	1377	48	4	4795	4	CSMD3	8	113353910	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	17852959	113353910	33010112	146	42358											
NDUFB9	4715	broad.mit.edu	37	chr8	125555397	125555397	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cataagaatgaaaaggatatGgcgaaggccacccagctgct	15	6	11	9	1	0	2	0	1	0	1	0	4	0	3	2	3	2	2	2	3	6	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr8:125555397G>A	uc003yrg.3	+	2	256	c.171G>A	c.(169-171)ATG>ATA	p.M57I	NDUFB9_uc011lim.1_Missense_Mutation_p.M57I	NM_005005	NP_004996	Q9Y6M9	NDUB9_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	57					mitochondrial electron transport, NADH to ubiquinone|sensory perception of sound|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)|skin(1)	2	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)		NADH(DB00157)	AAAAGGATATGGCGAAGGCCA	0.463													29	24					0	0	0	0	A	125555397	A	A	125555397	3	1	234	1	0	0	0	0	1	0	0	0	10342	1348	47	4	177	4	NDUFB9	8	125555397	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	12201487	125555397	20808625	147	42359											
SLC45A4	57210	broad.mit.edu	37	chr8	142231850	142231850	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaccaggtgaggctgtagtActgctccggaaggcctgcaa	10	7	14	10	1	0	1	0	1	0	0	1	3	1	2	3	4	4	5	3	4	5	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr8:142231850A>G	uc003ywd.1	-	2	411	c.103T>C	c.(103-105)TAC>CAC	p.Y35H	SLC45A4_uc003ywc.1_Missense_Mutation_p.Y35H|SLC45A4_uc010meq.1_Missense_Mutation_p.Y33H	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	86	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			AGGCTGTAGTACTGCTCCGGA	0.662													37	28					0	0	0	0	G	142231850	G	G	142231850	3	3	234	1	0	0	0	0	1	0	0	0	14707	391	14	5	2321	5	SLC45A4	8	142231850	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	16676453	142231850	4132172	148	42360											
RHPN1	114822	broad.mit.edu	37	chr8	144459586	144459586	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatgatccccctgggcctGaaggagaccaaggagctgga	10	5	13	13	0	0	3	0	2	0	1	1	6	1	5	5	4	1	1	5	4	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr8:144459586G>T	uc003yyb.2	+	4	475	c.342G>T	c.(340-342)CTG>CTT	p.L114L		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	114	BRO1.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CCCTGGGCCTGAAGGAGACCA	0.577													21	20					0.000295444	0.000566073	1	0	T	144459586	T	T	144459586	2	4	234	1	0	0	0	0	0	0	0	1	13415	1277	45	2		2	RHPN1	8	144459586	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2227736	144459586	1904436	149	42361											
EPPK1	83481	broad.mit.edu	37	chr8	144940823	144940823	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtgctccgtcccgtttccAggtcctggagcatttcctcc	3	13	9	16	3	0	0	0	0	0	0	7	1	6	1	6	2	2	3	6	2	0	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr8:144940823A>G	uc003zaa.1	-	1	6612	c.6599T>C	c.(6598-6600)CTG>CCG	p.L2200P		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2200						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCCCGTTTCCAGGTCCTGGAG	0.592													5	291					0	0	0	0	G	144940823	G	G	144940823	3	3	234	1	0	0	0	0	1	0	0	0	5214	188	7	5	667	5	EPPK1	8	144940823	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	481237	144940823	1423199	150	42362											
PRUNE2	158471	broad.mit.edu	37	chr9	79321004	79321004	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaggcgcggcagaggccagCtgcccaccctcttgaaagtt	8	7	12	14	2	2	2	1	1	1	1	2	2	2	2	3	3	2	3	3	3	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr9:79321004C>A	uc010mpk.2	-	8	6310	c.6186G>T	c.(6184-6186)CAG>CAT	p.Q2062H	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2062					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CAGAGGCCAGCTGCCCACCCT	0.522													38	114					2.04263e-09	4.49133e-09	1	0	A	79321004	A	A	79321004	3	1	234	1	0	0	0	0	1	0	0	0	12703	796	28	4	3128	4	PRUNE2	9	79321004	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08		79321004	61892427	151	42363											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112899643	112899643	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaatccgagaccaccttctGtcgggggacctccagaagac	10	7	10	14	2	1	3	0	0	1	3	4	5	3	4	5	2	0	0	5	2	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr9:112899643G>C	uc004bei.2	+	9	2707	c.2515G>C	c.(2515-2517)GTC>CTC	p.V839L	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.V607L|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.V607L|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.V417L|AKAP2_uc011lwi.1_Missense_Mutation_p.V465L|AKAP2_uc004bem.2_Missense_Mutation_p.V465L|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.V425L|AKAP2_uc011lwj.1_Missense_Mutation_p.V376L|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.V376L	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	376							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						ACCACCTTCTGTCGGGGGACC	0.607													64	57					0	0	0	0	C	112899643	C	C	112899643	3	2	234	1	0	0	0	0	1	0	0	0	11464	1377	48	4	1849	4	PALM2-AKAP2	9	112899643	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	33578639	112899643	28313788	152	42364											
DBC1	1620	broad.mit.edu	37	chr9	121929752	121929752	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacggggccctggccagtCtcatttcgcagtagggtagg	6	9	14	12	2	1	0	1	0	1	0	4	0	2	0	3	5	0	3	3	5	2	3	rs112348256	byFrequency	TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr9:121929752C>A	uc004bkc.2	-	8	2352	c.1896G>T	c.(1894-1896)GAG>GAT	p.E632D		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	632					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CCTGGCCAGTCTCATTTCGCA	0.537													91	97					6.03982e-29	1.60915e-28	1	0	A	121929752	A	A	121929752	3	1	234	1	0	0	0	0	1	0	0	0	4264	912	32	2	393	2	DBC1	9	121929752	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	9030109	121929752	19283679	153	42365											
USP6NL	9712	broad.mit.edu	37	chr10	11505159	11505159	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggactagaacttggctcagCgtgctttctcgggctaggag	7	11	14	9	2	2	1	1	0	1	1	3	3	2	3	0	4	3	3	0	4	3	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:11505159C>T	uc001ikt.3	-	15	2089	c.1768G>A	c.(1768-1770)GCT>ACT	p.A590T	USP6NL_uc001iks.1_Missense_Mutation_p.A607T	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	590						intracellular	Rab GTPase activator activity				0						CTTGGCTCAGCGTGCTTTCTC	0.562													18	24					0	0	0	0	T	11505159	T	T	11505159	3	4	234	1	0	0	0	0	1	0	0	0	17155	768	27	1	722	1	USP6NL	10	11505159	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08		11505159	124029588	154	42366											
DCLRE1C	64421	broad.mit.edu	37	chr10	14976392	14976392	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatacctggactcctaatTcttcactaaggttggtgaac	11	12	7	11	0	2	1	1	1	1	0	3	2	3	2	3	3	2	1	3	3	4	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:14976392T>A	uc001inn.2	-	8	750	c.665A>T	c.(664-666)GAA>GTA	p.E222V	DCLRE1C_uc010qbx.1_Missense_Mutation_p.E222V|DCLRE1C_uc001inl.2_Missense_Mutation_p.E102V|DCLRE1C_uc009xji.2_Missense_Mutation_p.E107V|DCLRE1C_uc001inm.2_Missense_Mutation_p.E102V|DCLRE1C_uc001ino.2_Missense_Mutation_p.E107V|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_Missense_Mutation_p.E102V|DCLRE1C_uc001inq.2_Missense_Mutation_p.E102V|DCLRE1C_uc001inr.2_Missense_Mutation_p.E107V|DCLRE1C_uc009xjj.1_RNA	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	222					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						GACTCCTAATTCTTCACTAAG	0.323								Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					28	108					0	0	0	0	A	14976392	A	A	14976392	3	1	234	1	0	0	0	0	1	0	0	0	4313	1783	62	5	1441	5	DCLRE1C	10	14976392	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	3471233	14976392	120558355	155	42367											
GPR158	57512	broad.mit.edu	37	chr10	25887011	25887011	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcactcaagaaatcccacaGcacttatgaccacgtgagag	14	7	7	13	1	2	3	2	2	0	2	3	4	3	3	2	0	1	1	2	0	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:25887011G>T	uc001isj.2	+	11	2516	c.2456G>T	c.(2455-2457)AGC>ATC	p.S819I	GPR158_uc001isk.2_Missense_Mutation_p.S194I	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	819	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AAATCCCACAGCACTTATGAC	0.512													22	135					2.08468e-23	5.47415e-23	1	0	T	25887011	T	T	25887011	3	4	234	1	0	0	0	0	1	0	0	0	6701	971	34	4	2498	4	GPR158	10	25887011	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	10910619	25887011	109647736	156	42368											
APBB1IP	54518	broad.mit.edu	37	chr10	26802519	26802519	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagtcttatcagactggaCaagagacacagaaaataaaa	20	7	8	6	0	2	4	1	1	1	3	2	6	2	5	0	1	0	0	0	1	7	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:26802519C>G	uc001iss.2	+	8	1064	c.743C>G	c.(742-744)ACA>AGA	p.T248R	APBB1IP_uc009xks.1_Missense_Mutation_p.T248R	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	248	Ras-associating.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						TCAGACTGGACAAGAGACACA	0.343													13	62					0	0	0	0	G	26802519	G	G	26802519	3	3	234	1	0	0	0	0	1	0	0	0	760	478	17	4	765	4	APBB1IP	10	26802519	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	915508	26802519	108732228	157	42369											
NCOA4	8031	broad.mit.edu	37	chr10	51585571	51585571	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagttatcttctggagaagAcaagtggctgcttcgaaaga	12	10	11	8	1	2	3	0	0	2	3	3	5	2	3	1	2	1	3	1	2	4	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:51585571A>T	uc001jis.3	+	8	1873	c.1670A>T	c.(1669-1671)GAC>GTC	p.D557V	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Missense_Mutation_p.D573V|NCOA4_uc010qhd.1_Missense_Mutation_p.D573V|NCOA4_uc010qhe.1_Missense_Mutation_p.D457V|NCOA4_uc010qhf.1_Missense_Mutation_p.D391V|NCOA4_uc001jit.2_Missense_Mutation_p.D557V|NCOA4_uc009xoo.2_Missense_Mutation_p.D557V	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	557					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						TCTGGAGAAGACAAGTGGCTG	0.388			T	RET	papillary thyroid 								30	60					0	0	0	0	T	51585571	T	T	51585571	3	4	234	1	0	0	0	0	1	0	0	0	10285	275	10	5	1748	5	NCOA4	10	51585571	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	24783052	51585571	83949176	158	42370											
RHOBTB1	9886	broad.mit.edu	37	chr10	62648688	62648688	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccccatggaaggacactcTggaattttgatgaccggtgg	9	10	13	9	1	1	2	0	2	1	0	2	5	2	5	3	5	0	0	3	5	2	2	rs148015761		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:62648688T>A	uc001jli.2	-	7	1176	c.738A>T	c.(736-738)CCA>CCT	p.P246P	RHOBTB1_uc001jlh.2_Silent_p.P246P|RHOBTB1_uc001jlj.2_Silent_p.P246P|RHOBTB1_uc001jlk.2_Silent_p.P246P|RHOBTB1_uc009xpe.1_Silent_p.P184P|RHOBTB1_uc001jll.2_5'UTR	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	246					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					AAGGACACTCTGGAATTTTGA	0.478													41	137					0	0	0	0	A	62648688	A	A	62648688	2	1	234	1	0	0	0	0	0	0	0	1	13398	1567	55	5		5	RHOBTB1	10	62648688	Silent	SNP	T	TCGA-CV-7242-01A-11D-2012-08	11063117	62648688	72886059	159	42371											
USP54	159195	broad.mit.edu	37	chr10	75276690	75276690	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggaggcttagaatcagaaGgggaagagttcttccttaga	14	9	13	5	0	2	4	1	0	1	4	3	6	3	6	1	4	0	2	1	4	6	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:75276690G>A	uc001juo.2	-	18	3511	c.3494C>T	c.(3493-3495)CCT>CTT	p.P1165L	USP54_uc010qkk.1_Missense_Mutation_p.P347L|USP54_uc001juk.2_Missense_Mutation_p.P253L|USP54_uc001jul.2_Missense_Mutation_p.P253L|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	1165					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					AGAATCAGAAGGGGAAGAGTT	0.507													49	115					0	0	0	0	A	75276690	A	A	75276690	3	1	234	1	0	0	0	0	1	0	0	0	17153	1000	35	4	1580	4	USP54	10	75276690	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	12628002	75276690	60258057	160	42372											
KCNMA1	3778	broad.mit.edu	37	chr10	79163662	79163662	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcggatatcatcaccccCgcccagtccttcacggaggt	7	8	11	15	3	3	0	3	0	0	0	4	2	4	2	4	4	0	0	4	4	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:79163662C>A	uc001jxn.2	-	2	675	c.498G>T	c.(496-498)GCG>GCT	p.A166A	KCNMA1_uc001jxj.2_Silent_p.A166A|KCNMA1_uc001jxo.2_Silent_p.A166A|KCNMA1_uc001jxm.2_Silent_p.A166A|KCNMA1_uc001jxq.2_Silent_p.A166A	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	166	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TCATCACCCCCGCCCAGTCCT	0.607													7	27					0.00198382	0.00372285	1	0	A	79163662	A	A	79163662	2	1	234	1	0	0	0	0	0	0	0	1	8112	639	23	3		3	KCNMA1	10	79163662	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	3886972	79163662	56371085	161	42373											
PKD2L1	9033	broad.mit.edu	37	chr10	102089669	102089669	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggcagcagctggacacctgGgtcctgtatgccgtctcctg	6	9	13	13	1	1	0	0	0	1	0	3	1	2	1	4	3	3	4	4	3	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:102089669G>T	uc001kqx.1	-	1	575	c.192C>A	c.(190-192)ACC>ACA	p.T64T	PKD2L1_uc009xwm.1_Missense_Mutation_p.P10H	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	64	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TGGACACCTGGGTCCTGTATG	0.567													9	60					7.48243e-07	1.55175e-06	1	0	T	102089669	T	T	102089669	2	4	234	1	0	0	0	0	0	0	0	1	12022	1219	43	4		4	PKD2L1	10	102089669	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	22926007	102089669	33445078	162	42374											
PSD	5662	broad.mit.edu	37	chr10	104173584	104173584	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgagtggcagggactaggggGctccctccctggggccagct	5	7	17	12	0	0	1	0	1	0	0	2	2	2	2	3	6	1	3	3	6	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:104173584G>T	uc001kvg.1	-	5	2022	c.1495C>A	c.(1495-1497)CCC>ACC	p.P499T	PSD_uc001kvh.1_Missense_Mutation_p.P120T|PSD_uc009xxd.1_Missense_Mutation_p.P499T	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	499					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GGACTAGGGGGCTCCCTCCCT	0.632													9	33					1.33987e-11	3.09527e-11	1	0	T	104173584	T	T	104173584	3	4	234	1	0	0	0	0	1	0	0	0	12708	1203	42	4	1631	4	PSD	10	104173584	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2083915	104173584	31361163	163	42375											
SMC3	9126	broad.mit.edu	37	chr10	112328765	112328765	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcagttcaaaacataatGtgattggtaagtgttcttgg	11	15	9	6	0	3	1	2	1	1	0	3	1	3	1	1	2	1	3	1	2	4	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:112328765G>A	uc001kze.2	+	2	211	c.85G>A	c.(85-87)GTG>ATG	p.V29M		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	29					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		AAAACATAATGTGATTGGTAA	0.328													32	28					0	0	0	0	A	112328765	A	A	112328765	3	1	234	1	0	0	0	0	1	0	0	0	14848	1377	48	4	91	4	SMC3	10	112328765	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	8155181	112328765	23205982	164	42376											
WDR11	55717	broad.mit.edu	37	chr10	122624702	122624702	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggtgtgattgcaatagaacGcacaggagttccatttttac	11	12	11	7	1	0	2	0	1	0	1	1	3	1	3	1	2	3	3	1	2	4	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:122624702G>T	uc010qtf.1	+	6	1095	c.857G>T	c.(856-858)CGC>CTC	p.R286L	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	286						integral to membrane					0						GCAATAGAACGCACAGGAGTT	0.358													20	47					2.4624e-09	5.39805e-09	1	0	T	122624702	T	T	122624702	3	4	234	1	0	0	0	0	1	0	0	0	17341	1087	38	3	879	3	WDR11	10	122624702	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	10295937	122624702	12910045	165	42377											
DMBT1	1755	broad.mit.edu	37	chr10	124339338	124339338	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctgctcaggacatgagtcCtacctgtggagctgccccca	7	8	11	15	1	1	1	1	1	0	0	2	3	2	3	4	2	4	3	4	2	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:124339338C>T	uc001lgk.1	+	10	1030	c.924C>T	c.(922-924)TCC>TCT	p.S308S	DMBT1_uc001lgl.1_Silent_p.S308S|DMBT1_uc001lgm.1_Silent_p.S308S|DMBT1_uc009xzz.1_Silent_p.S308S|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Silent_p.S160S	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	308	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GACATGAGTCCTACCTGTGGA	0.597													59	131					0	0	0	0	T	124339338	T	T	124339338	2	4	234	1	0	0	0	0	0	0	0	1	4599	668	24	4		4	DMBT1	10	124339338	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1714636	124339338	11195409	166	42378											
DMBT1	1755	broad.mit.edu	37	chr10	124358568	124358568	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccccacaatggctggctcTcccacaactgtggccatagt	8	8	9	16	0	1	0	0	0	1	0	2	0	1	0	4	3	1	2	4	3	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr10:124358568T>A	uc001lgk.1	+	26	3341	c.3235T>A	c.(3235-3237)TCC>ACC	p.S1079T	DMBT1_uc001lgl.1_Missense_Mutation_p.S1069T|DMBT1_uc001lgm.1_Missense_Mutation_p.S580T|DMBT1_uc009xzz.1_Missense_Mutation_p.S1079T|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Missense_Mutation_p.S40T	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1079	SRCR 8.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGGCTGGCTCTCCCACAACTG	0.572													7	180					0	0	0	0	A	124358568	A	A	124358568	3	1	234	1	0	0	0	0	1	0	0	0	4599	1551	54	5	3337	5	DMBT1	10	124358568	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	19230	124358568	11176179	167	42379											
OR51G2	81282	broad.mit.edu	37	chr11	4935987	4935987	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtcactcgatcccggatctGtttggtcttcacactgtaga	7	13	9	12	3	4	1	2	0	2	1	6	3	5	2	1	2	0	2	1	2	1	3	rs150667862	by1000genomes	TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:4935987G>A	uc001lzr.1	-	1	907	c.907C>T	c.(907-909)CAG>TAG	p.Q303*		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	303	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCCCGGATCTGTTTGGTCTTC	0.478													12	19					0	0	0	0	A	4935987	A	A	4935987	4	1	234	1	0	0	0	0	0	1	0	0	11153	1386	48	4	41	4	OR51G2	11	4935987	Nonsense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08		4935987	130070529	168	42380											
OR52D1	390066	broad.mit.edu	37	chr11	5510098	5510098	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcctggtcattgccatGgacaatgctcttcatgcacc	8	12	7	14	0	4	0	3	0	1	0	5	1	5	1	3	2	3	2	3	2	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:5510098G>C	uc010qzg.1	+	1	162	c.162G>C	c.(160-162)ATG>ATC	p.M54I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCATTGCCATGGACAATGCTC	0.527													31	99					0	0	0	0	C	5510098	C	C	5510098	3	2	234	1	0	0	0	0	1	0	0	0	11168	1348	47	4	164	4	OR52D1	11	5510098	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	574111	5510098	129496418	169	42381											
UBQLN3	50613	broad.mit.edu	37	chr11	5530436	5530436	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtaaatggagcttggctgaGggagtgatccaggacttggg	9	9	18	5	0	0	2	0	2	0	0	1	5	1	5	1	6	1	3	1	6	2	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:5530436G>T	uc001may.1	-	2	439	c.353C>A	c.(352-354)CCT>CAT	p.P118H	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	118										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTTGGCTGAGGGAGTGATCC	0.607													14	36					4.3838e-07	9.16955e-07	1	0	T	5530436	T	T	5530436	3	4	234	1	0	0	0	0	1	0	0	0	16966	1000	35	4	1618	4	UBQLN3	11	5530436	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	20338	5530436	129476080	170	42382											
OR56A3	390083	broad.mit.edu	37	chr11	5968729	5968729	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaacaccaccctcctgatGaccatctggctggaggcctc	8	7	9	17	0	1	2	0	2	1	0	3	3	2	3	6	3	1	1	6	3	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:5968729G>T	uc010qzt.1	+	1	153	c.153G>T	c.(151-153)ATG>ATT	p.M51I		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCTCCTGATGACCATCTGGC	0.607													26	105					1.5548e-18	3.94099e-18	1	0	T	5968729	T	T	5968729	3	4	234	1	0	0	0	0	1	0	0	0	11188	1290	45	2	155	2	OR56A3	11	5968729	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	438293	5968729	129037787	171	42383											
OR56A1	120796	broad.mit.edu	37	chr11	6048387	6048387	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaagttggcacagatgcagTtctcaatgacattttcccca	12	11	7	11	0	1	2	1	1	1	1	3	2	2	2	2	1	1	4	2	1	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:6048387T>A	uc010qzw.1	-	1	548	c.548A>T	c.(547-549)AAC>ATC	p.N183I		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACAGATGCAGTTCTCAATGAC	0.478													37	77					0	0	0	0	A	6048387	A	A	6048387	3	1	234	1	0	0	0	0	1	0	0	0	11187	1725	60	5	412	5	OR56A1	11	6048387	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	79658	6048387	128958129	172	42384											
TRIM3	10612	broad.mit.edu	37	chr11	6477901	6477901	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcctgtgcgcaccaaccgcCcgtccttgtctttggtagtg	4	12	11	14	3	1	0	0	0	1	0	2	0	2	0	5	1	3	2	5	1	2	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:6477901C>G	uc001mdh.2	-	7	1442	c.1055G>C	c.(1054-1056)GGG>GCG	p.G352A	TRIM3_uc001mdi.2_Missense_Mutation_p.G352A|TRIM3_uc010raj.1_Missense_Mutation_p.G233A|TRIM3_uc009yfd.2_Missense_Mutation_p.G352A|TRIM3_uc010rak.1_Missense_Mutation_p.G352A|TRIM3_uc001mdj.2_Missense_Mutation_p.G233A	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	352	Filamin.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACCAACCGCCCGTCCTTGTC	0.672													18	57					0	0	0	0	G	6477901	G	G	6477901	3	3	234	1	0	0	0	0	1	0	0	0	16571	623	22	4	1207	4	TRIM3	11	6477901	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	429514	6477901	128528615	173	42385											
OR10A5	144124	broad.mit.edu	37	chr11	6867169	6867169	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccaaaatgctggggaccCtgcttgcccaggacacaacc	10	6	10	15	0	0	0	0	0	0	0	0	2	0	2	4	3	5	2	4	3	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:6867169C>A	uc001met.1	+	1	256	c.256C>A	c.(256-258)CTG>ATG	p.L86M		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCTGGGGACCCTGCTTGCCCA	0.498													25	128					4.87955e-14	1.16028e-13	1	0	A	6867169	A	A	6867169	3	1	234	1	0	0	0	0	1	0	0	0	10947	680	24	4	258	4	OR10A5	11	6867169	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	389268	6867169	128139347	174	42386											
OR10A3	26496	broad.mit.edu	37	chr11	7960256	7960256	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagccaatgagatcagtttcTtggtttcgggtgagtagcca	10	12	12	7	1	2	2	1	2	1	1	3	3	2	2	2	2	2	3	2	2	3	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:7960256T>C	uc010rbi.1	-	1	812	c.812A>G	c.(811-813)AAG>AGG	p.K271R		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GATCAGTTTCTTGGTTTCGGG	0.443													11	56					0	0	0	0	C	7960256	C	C	7960256	3	2	234	1	0	0	0	0	1	0	0	0	10945	1609	56	5	135	5	OR10A3	11	7960256	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	1093087	7960256	127046260	175	42387											
FSHB	2488	broad.mit.edu	37	chr11	30253578	30253578	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgcataagcatcaacacCacttggtgtgctggctactg	9	12	9	11	0	2	0	1	0	1	0	2	0	2	0	1	2	5	4	1	2	3	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:30253578C>T	uc001msl.2	+	2	198	c.129C>T	c.(127-129)ACC>ACT	p.T43T	FSHB_uc001msm.2_Silent_p.T43T|FSHB_uc001msn.2_Silent_p.T43T	NM_000510	NP_000501	P01225	FSHB_HUMAN	follicle stimulating hormone, beta polypeptide	43					cellular nitrogen compound metabolic process|female gamete generation|female pregnancy|ovarian follicle development|peptide hormone processing|progesterone biosynthetic process|spermatogenesis|transforming growth factor beta receptor signaling pathway	cytoplasm|extracellular region|soluble fraction	follicle-stimulating hormone activity|protein heterodimerization activity			ovary(3)	3					Follitropin beta(DB00066)|Thyrotropin Alfa(DB00024)|Urofollitropin(DB00094)	GCATCAACACCACTTGGTGTG	0.458													15	51					0	0	0	0	T	30253578	T	T	30253578	2	4	234	1	0	0	0	0	0	0	0	1	6106	581	21	4		4	FSHB	11	30253578	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	22293322	30253578	104752938	176	42388											
LRRC4C	57689	broad.mit.edu	37	chr11	40136707	40136707	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatacagatgtcagggatGtggaggcccgacatttcagc	12	8	13	8	1	2	2	2	0	0	2	2	5	2	4	1	3	2	0	1	3	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:40136707G>T	uc001mxa.1	-	2	3100	c.1136C>A	c.(1135-1137)ACA>AAA	p.T379K	LRRC4C_uc001mxc.1_Missense_Mutation_p.T375K|LRRC4C_uc001mxd.1_Missense_Mutation_p.T375K|LRRC4C_uc001mxb.1_Missense_Mutation_p.T375K	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	379	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TGTCAGGGATGTGGAGGCCCG	0.498													21	80					2.70639e-06	5.48796e-06	1	0	T	40136707	T	T	40136707	3	4	234	1	0	0	0	0	1	0	0	0	9058	1377	48	4	790	4	LRRC4C	11	40136707	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	9883129	40136707	94869809	177	42389											
OR8H2	390151	broad.mit.edu	37	chr11	55872323	55872323	+	5'Flank	DEL	G	-	-																															taaacagaaagtttttttttGtttgttttttgttttttgag																								rs113669153		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	f50dc054-f0b0-4b11-be76-09ae612abc8e	g.chr11:55872323delG	uc010riy.1	+							NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					Gtttttttttgtttgtttttt	0.109										HNSCC(53;0.14)			---	---	---								-	55872323	-	-	55872323	6	5	234	0	1	1	0	1	0	0	0	0	11292	1392	48	0		0	OR8H2	11	55872323	5'Flank	DEL	G	TCGA-CV-7242-01A-11D-2012-08	15735616	55872323	79134193	178	42390											
OR9G9	504191	broad.mit.edu	37	chr11	56468409	56468409	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttctgtgatttgcttccCttggtggagctggcctgtgg	2	18	13	8	0	1	1	0	1	1	0	2	2	2	2	2	4	2	2	2	4	0	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:56468409C>T	uc010rjn.1	+	1	546	c.546C>T	c.(544-546)CCC>CCT	p.P182P		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATTTGCTTCCCTTGGTGGAGC	0.468													28	105					0	0	0	0	T	56468409	T	T	56468409	2	4	234	1	0	0	0	0	0	0	0	1	11306	668	24	4		4	OR9G9	11	56468409	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	596086	56468409	78538107	179	42391											
AHNAK	79026	broad.mit.edu	37	chr11	62284353	62284353	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccactcccctgtaacttgcCtgtctcatcatcgctcccag	6	11	5	19	1	2	0	2	0	1	0	6	0	4	0	5	0	2	2	5	0	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:62284353C>A	uc001ntl.2	-	5	17836	c.17536G>T	c.(17536-17538)GGC>TGC	p.G5846C	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5846					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGTAACTTGCCTGTCTCATCA	0.512													32	106					3.90053e-15	9.49128e-15	1	0	A	62284353	A	A	62284353	3	1	234	1	0	0	0	0	1	0	0	0	414	681	24	4	256	4	AHNAK	11	62284353	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	5815944	62284353	72722163	180	42392											
DPF2	5977	broad.mit.edu	37	chr11	65113793	65113793	+	Frame_Shift_Del	DEL	G	-	-																															ccgctggcagtgcatcgagtGcaaatgttgcaatatctgcg																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:65113793delG	uc001odm.2	+	9	992	c.980delG	c.(979-981)TGCfs	p.C327fs	DPF2_uc001odn.2_Frame_Shift_Del_p.C341fs|DPF2_uc010roe.1_Intron	NM_006268	NP_006259	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	327	PHD-type 1.|PHD-type 2.				apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						TGCATCGAGTGCAAATGTTGC	0.552													---	---	---								-	65113793	-	-	65113793	7	5	234	1	0	1	0	1	0	0	0	0	4739	1319	46	0	1014	0	DPF2	11	65113793	Frame_Shift_Del	DEL	G	TCGA-CV-7242-01A-11D-2012-08	2829440	65113793	69892723	181	42393											
CDK2AP2	10263	broad.mit.edu	37	chr11	67275066	67275066	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctttggccccactcacctgCacgtagcccatggaaggcgg	7	7	12	15	2	1	0	1	0	0	0	1	1	1	1	4	4	2	3	4	4	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:67275066C>A	uc001oma.2	-	2	726	c.177G>T	c.(175-177)GTG>GTT	p.V59V	PITPNM1_uc001oly.2_5'Flank|PITPNM1_uc001olz.2_5'Flank|CDK2AP2_uc009yry.2_RNA|CDK2AP2_uc001omb.2_Silent_p.V68V	NM_005851	NP_005842	O75956	CDKA2_HUMAN	cyclin-dependent kinase 2 associated protein 2	59											0						CACTCACCTGCACGTAGCCCA	0.627													9	39					5.4927e-09	1.17932e-08	1	0	A	67275066	A	A	67275066	2	1	234	1	0	0	0	0	0	0	0	1	3154	697	25	4		4	CDK2AP2	11	67275066	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	2161273	67275066	67731450	182	42394											
NAALAD2	10003	broad.mit.edu	37	chr11	89902135	89902135	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggagagaagcattgcttaTatcaactcggattcatctat	13	12	8	8	1	3	1	2	0	1	1	4	4	3	3	0	2	3	2	0	2	5	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:89902135T>A	uc001pdf.3	+	12	1426	c.1317T>A	c.(1315-1317)TAT>TAA	p.Y439*	NAALAD2_uc009yvx.2_Nonsense_Mutation_p.Y406*|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	439	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GCATTGCTTATATCAACTCGG	0.284													16	34					0	0	0	0	A	89902135	A	A	89902135	4	1	234	1	0	0	0	0	0	1	0	0	10181	1413	49	5	1363	5	NAALAD2	11	89902135	Nonsense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	22627069	89902135	45104381	183	42395											
EXPH5	23086	broad.mit.edu	37	chr11	108383615	108383615	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagatctaaagaatcacaCgaggtcttgtggccaggagt	13	8	12	8	1	3	2	1	0	2	2	3	5	3	3	1	3	0	0	1	3	3	2	rs114840330	byFrequency	TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:108383615C>A	uc001pkk.2	-	6	2730	c.2619G>T	c.(2617-2619)TCG>TCT	p.S873S	EXPH5_uc010rvy.1_Silent_p.S685S|EXPH5_uc010rvz.1_Silent_p.S717S|EXPH5_uc010rwa.1_Silent_p.S797S	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	873					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AAGAATCACACGAGGTCTTGT	0.413													34	96					1.36161e-19	3.48764e-19	1	0	A	108383615	A	A	108383615	2	1	234	1	0	0	0	0	0	0	0	1	5347	523	19	3		3	EXPH5	11	108383615	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	18481480	108383615	26622901	184	42396											
ZW10	9183	broad.mit.edu	37	chr11	113630936	113630936	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaggtcagcagcaccttttGatggtgggaacttccataca	10	11	11	9	0	1	2	1	2	0	0	2	3	2	3	2	3	4	2	2	3	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:113630936G>C	uc001poe.2	-	5	612	c.575C>G	c.(574-576)TCA>TGA	p.S192*	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	192	Interaction with RINT1.				cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		AGCACCTTTTGATGGTGGGAA	0.423													15	35					0	0	0	0	C	113630936	C	C	113630936	4	2	234	1	0	0	0	0	0	1	0	0	18314	1294	45	2	1812	2	ZW10	11	113630936	Nonsense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	5247321	113630936	21375580	185	42397											
IL10RA	3587	broad.mit.edu	37	chr11	117869498	117869498	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagagacccaagacaccatCcacccgcttgatgaggaggc	12	4	10	15	1	0	4	0	2	0	2	1	6	1	5	5	2	0	1	5	2	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:117869498C>A	uc001prv.2	+	7	956	c.879C>A	c.(877-879)ATC>ATA	p.I293I	IL10RA_uc010rxl.1_Silent_p.I273I|IL10RA_uc010rxm.1_Silent_p.I273I|IL10RA_uc010rxn.1_Silent_p.I144I|IL10RA_uc001prw.2_Silent_p.I144I	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	293	Cytoplasmic (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		AAGACACCATCCACCCGCTTG	0.577													13	45					0.00136819	0.00258083	1	0	A	117869498	A	A	117869498	2	1	234	1	0	0	0	0	0	0	0	1	7659	845	30	2		2	IL10RA	11	117869498	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	4238562	117869498	17137018	186	42398											
MPZL3	196264	broad.mit.edu	37	chr11	118122936	118122937	+	Splice_Site	DEL	CC	-	-																															gtagccagccggagcactcaCcctggaagaacaggacgccc																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:118122936_118122937delCC	uc001psm.2	-	1	75	c.73_splice	c.e1+1	p.G25_splice	MPZL3_uc010rxy.1_Splice_Site_p.D25_splice|MPZL3_uc010rxz.1_Splice_Site|MPZL3_uc009yzy.2_Splice_Site	NM_198275	NP_938016	Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3 precursor						cell adhesion	integral to membrane					0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GGAGCACTCACCCTGGAAGAAC	0.644													---	---	---								-	118122937	-	-	118122936	8	5	234	1	0	1	0	1	0	0	1	0	9804	521	18	0	657	0	MPZL3	11	118122936	Splice_Site	DEL	CC	TCGA-CV-7242-01A-11D-2012-08	253438	118122936	16883580	187	42399											
FOXR1	283150	broad.mit.edu	37	chr11	118850289	118850289	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggaggctctggtcccggccCcctctcaattacttccacct	5	10	9	17	1	2	0	1	0	2	0	5	1	4	1	5	4	1	1	5	4	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:118850289C>G	uc001pui.2	+	4	747	c.522C>G	c.(520-522)CCC>CCG	p.P174P	FOXR1_uc001puj.2_RNA|FOXR1_uc001puk.2_Intron	NM_181721	NP_859072	Q6PIV2	FOXR1_HUMAN	forkhead box R1	174	Fork-head.				embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GGTCCCGGCCCCCTCTCAATT	0.597													15	85					0	0	0	0	G	118850289	G	G	118850289	2	3	234	1	0	0	0	0	0	0	0	1	6065	610	22	4		4	FOXR1	11	118850289	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	727353	118850289	16156227	188	42400											
OR10G8	219869	broad.mit.edu	37	chr11	123901012	123901012	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgttccatcctgcggatccGcacctcagaggggaagcaca	9	7	11	14	2	1	1	1	0	0	1	4	3	4	3	4	3	2	3	4	3	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:123901012G>T	uc001pzp.1	+	1	683	c.683G>T	c.(682-684)CGC>CTC	p.R228L		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTGCGGATCCGCACCTCAGAG	0.527													29	80					2.12542e-12	4.97293e-12	1	0	T	123901012	T	T	123901012	3	4	234	1	0	0	0	0	1	0	0	0	10957	1087	38	3	685	3	OR10G8	11	123901012	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	5050723	123901012	11105504	189	42401											
OR10G8	219869	broad.mit.edu	37	chr11	123901065	123901065	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgcctcccactgtatcGtggtcctttgcttctttggc	2	16	9	14	1	1	0	0	0	1	0	4	0	3	0	4	2	2	2	4	2	1	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:123901065G>A	uc001pzp.1	+	1	736	c.736G>A	c.(736-738)GTG>ATG	p.V246M		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CCACTGTATCGTGGTCCTTTG	0.542													18	95					0	0	0	0	A	123901065	A	A	123901065	3	1	234	1	0	0	0	0	1	0	0	0	10957	1145	40	1	738	1	OR10G8	11	123901065	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	53	123901065	11105451	190	42402											
SPATA19	219938	broad.mit.edu	37	chr11	133714155	133714155	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccttacctccatcttatgaaCtggattcgtgttctctcctc	6	16	5	14	1	2	1	0	1	2	0	7	2	4	2	4	1	2	1	4	1	3	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:133714155C>G	uc001qgv.1	-	4	396	c.345G>C	c.(343-345)CAG>CAC	p.Q115H		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	115					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		ATCTTATGAACTGGATTCGTG	0.537													38	65					0	0	0	0	G	133714155	G	G	133714155	3	3	234	1	0	0	0	0	1	0	0	0	15070	564	20	4	170	4	SPATA19	11	133714155	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	9813090	133714155	1292361	191	42403											
GLB1L2	89944	broad.mit.edu	37	chr11	134240963	134240963	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcaatgggggaaatggacAgtccttcgggtacattctct	10	11	12	8	1	2	0	1	0	1	0	5	2	3	2	1	4	1	1	1	4	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr11:134240963A>T	uc001qhp.2	+	13	1465	c.1277A>T	c.(1276-1278)CAG>CTG	p.Q426L	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	426					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		GGAAATGGACAGTCCTTCGGG	0.537													26	105					0	0	0	0	T	134240963	T	T	134240963	3	4	234	1	0	0	0	0	1	0	0	0	6466	188	7	5	1327	5	GLB1L2	11	134240963	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	526808	134240963	765553	192	42404											
SLC6A12	6539	broad.mit.edu	37	chr12	309926	309926	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccaggtcatggatgcccGaggtgatgcccagaactcgt	9	7	13	12	2	1	2	1	1	0	1	2	4	1	3	3	3	4	0	3	3	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:309926G>T	uc001qhz.2	-	8	1145	c.602C>A	c.(601-603)TCG>TAG	p.S201*	SLC6A12_uc001qhx.2_5'Flank|SLC6A12_uc001qhy.2_5'Flank|SLC6A12_uc001qia.2_Nonsense_Mutation_p.S201*|SLC6A12_uc001qib.2_Nonsense_Mutation_p.S201*|SLC6A12_uc009zdh.1_Nonsense_Mutation_p.S201*|SLC6A12_uc009zdi.1_RNA	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	201	Extracellular (Potential).				cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			ATGGATGCCCGAGGTGATGCC	0.567													29	82					5.45727e-16	1.35044e-15	1	0	T	309926	T	T	309926	4	4	234	1	0	0	0	0	0	1	0	0	14739	1059	37	3	1282	3	SLC6A12	12	309926	Nonsense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08		309926	133541969	193	42405											
CLEC7A	64581	broad.mit.edu	37	chr12	10279171	10279171	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttaactatgcccttgccTgtggttttgacagctttggt	5	17	9	10	0	0	1	0	1	0	0	0	1	0	1	3	2	4	2	3	2	2	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:10279171T>A	uc001qxg.2	-	3	526	c.339A>T	c.(337-339)ACA>ACT	p.T113T	CLEC7A_uc001qxe.3_RNA|CLEC7A_uc001qxf.2_Intron|CLEC7A_uc001qxh.2_Intron|CLEC7A_uc001qxi.2_Silent_p.T113T|CLEC7A_uc001qxj.2_Intron|CLEC7A_uc009zhg.1_Intron|CLEC7A_uc001qxk.1_RNA|CLEC7A_uc001qxl.1_Silent_p.T113T|CLEC7A_uc010sgy.1_Intron|CLEC7A_uc001qxm.1_Intron	NM_197947	NP_922938	Q9BXN2	CLC7A_HUMAN	dendritic cell-associated C-type lectin 1	113	Extracellular (Potential).				carbohydrate mediated signaling|defense response to protozoan|inflammatory response|innate immune response|phagocytosis, recognition|T cell activation	cytoplasm|integral to membrane	metal ion binding|MHC protein binding|sugar binding			central_nervous_system(1)	1						TGCCCTTGCCTGTGGTTTTGA	0.423													31	89					0	0	0	0	A	10279171	A	A	10279171	2	1	234	1	0	0	0	0	0	0	0	1	3536	1594	55	5		5	CLEC7A	12	10279171	Silent	SNP	T	TCGA-CV-7242-01A-11D-2012-08	9969245	10279171	123572724	194	42406											
OLR1	4973	broad.mit.edu	37	chr12	10319426	10319426	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaagggtttctatcatttcCttgagttcgttttctgactc	6	18	8	9	1	3	2	1	2	2	0	6	2	4	2	1	1	0	4	1	1	2	7	rs146929021		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:10319426C>T	uc001qxo.1	-	3	423	c.309G>A	c.(307-309)AAG>AAA	p.K103K	OLR1_uc010sgz.1_5'UTR|OLR1_uc010sha.1_Silent_p.K103K	NM_002543	NP_002534	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like)	103	Extracellular (Potential).|Neck.|Potential.				blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			ovary(1)	1						CTATCATTTCCTTGAGTTCGT	0.448													36	132					0	0	0	0	T	10319426	T	T	10319426	2	4	234	1	0	0	0	0	0	0	0	1	10917	680	24	4		4	OLR1	12	10319426	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	40255	10319426	123532469	195	42407											
SLCO1A2	6579	broad.mit.edu	37	chr12	21457428	21457428	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaatacccaaaggcaggatGggagtttcacccattccacg	13	7	10	11	1	1	0	1	0	0	0	2	3	2	2	3	3	1	2	3	3	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:21457428G>T	uc001rer.2	-	5	773	c.522C>A	c.(520-522)CCC>CCA	p.P174P	SLCO1A2_uc001res.2_Silent_p.P174P|SLCO1A2_uc010siq.1_Silent_p.P42P|SLCO1A2_uc010sio.1_Silent_p.P42P|SLCO1A2_uc010sip.1_Silent_p.P42P|SLCO1A2_uc001ret.2_Silent_p.P172P|SLCO1A2_uc001reu.2_Silent_p.P154P	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	174	Helical; Name=4; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						AAGGCAGGATGGGAGTTTCAC	0.343													20	36					2.39187e-15	5.85929e-15	1	0	T	21457428	T	T	21457428	2	4	234	1	0	0	0	0	0	0	0	1	14786	1335	47	4		4	SLCO1A2	12	21457428	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	11138002	21457428	112394467	196	42408											
LRRK2	120892	broad.mit.edu	37	chr12	40714839	40714839	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccttttgcctttagtttGtctgaccacaggcctgtgat	5	17	9	10	0	1	2	0	2	1	0	2	2	2	2	4	1	1	1	4	1	1	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:40714839G>T	uc001rmg.3	+	35	5140	c.5019G>T	c.(5017-5019)TTG>TTT	p.L1673F	LRRK2_uc009zjw.2_Missense_Mutation_p.L511F|LRRK2_uc001rmi.2_Missense_Mutation_p.L506F	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1673					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CCTTTAGTTTGTCTGACCACA	0.388													27	118					1.75199e-13	4.13899e-13	1	0	T	40714839	T	T	40714839	3	4	234	1	0	0	0	0	1	0	0	0	9083	1368	48	4	5157	4	LRRK2	12	40714839	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	19257411	40714839	93137056	197	42409											
LRRK2	120892	broad.mit.edu	37	chr12	40728910	40728910	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaggacaaagccagcctcActagaaccctacagcacagg	15	3	9	14	0	1	1	1	0	0	1	1	2	1	2	3	2	6	2	3	2	4	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:40728910A>T	uc001rmg.3	+	40	6020	c.5899A>T	c.(5899-5901)ACT>TCT	p.T1967S	LRRK2_uc009zjw.2_Missense_Mutation_p.T805S|LRRK2_uc001rmi.2_Missense_Mutation_p.T800S	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1967	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGCCAGCCTCACTAGAACCCT	0.507													24	58					0	0	0	0	T	40728910	T	T	40728910	3	4	234	1	0	0	0	0	1	0	0	0	9083	159	6	5	6057	5	LRRK2	12	40728910	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	14071	40728910	93122985	198	42410											
DBX2	440097	broad.mit.edu	37	chr12	45429852	45429852	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaggacccaccgcagcacGccgagtagaatggcggggtg	10	3	16	12	4	0	1	0	0	0	1	0	4	0	2	3	4	1	3	3	4	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:45429852G>T	uc001rok.1	-	2	621	c.449C>A	c.(448-450)GCG>GAG	p.A150E		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	150						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		accgcagcacgccgagtagaa	0.06													5	27					2.0095e-06	4.09758e-06	1	0	T	45429852	T	T	45429852	3	4	234	1	0	0	0	0	1	0	0	0	4277	1087	38	3	582	3	DBX2	12	45429852	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	4700942	45429852	88422043	199	42411											
SCN8A	6334	broad.mit.edu	37	chr12	52115638	52115638	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acggtggactgcaacggcgtGgtgtccctcatcggcggccc	5	7	15	14	5	1	0	1	0	0	0	3	1	2	1	2	6	2	1	2	6	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:52115638G>T	uc001ryw.2	+	12	2122	c.1944G>T	c.(1942-1944)GTG>GTT	p.V648V	SCN8A_uc010snl.1_Silent_p.V513V|SCN8A_uc001ryx.1_Silent_p.V513V|SCN8A_uc001ryz.1_Silent_p.V513V|SCN8A_uc001ryy.2_Silent_p.V513V	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	648					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GCAACGGCGTGGTGTCCCTCA	0.577													18	69					4.35082e-09	9.45267e-09	1	0	T	52115638	T	T	52115638	2	4	234	1	0	0	0	0	0	0	0	1	13989	1335	47	4		4	SCN8A	12	52115638	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	6685786	52115638	81736257	200	42412											
CALCOCO1	57658	broad.mit.edu	37	chr12	54115880	54115880	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctctcgagctcctgcactcGgctcctcagctctgtcacct	4	11	7	19	2	4	0	2	0	2	0	8	1	6	0	4	1	3	4	4	1	0	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:54115880G>A	uc001sef.2	-	5	682	c.538C>T	c.(538-540)CGA>TGA	p.R180*	CALCOCO1_uc010som.1_Nonsense_Mutation_p.R147*|CALCOCO1_uc010son.1_Nonsense_Mutation_p.R57*|CALCOCO1_uc001seh.2_Nonsense_Mutation_p.R180*|CALCOCO1_uc009znd.2_Nonsense_Mutation_p.R180*|CALCOCO1_uc001seg.2_Nonsense_Mutation_p.R57*|CALCOCO1_uc010soo.1_Nonsense_Mutation_p.R173*	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	180	Potential.|N-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						TCCTGCACTCGGCTCCTCAGC	0.607													32	81					0	0	0	0	A	54115880	A	A	54115880	4	1	234	1	0	0	0	0	0	1	0	0	2589	1124	39	1	1581	1	CALCOCO1	12	54115880	Nonsense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2000242	54115880	79736015	201	42413											
OR10A7	121364	broad.mit.edu	37	chr12	55615418	55615418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaagcacttgcctccacaCtcctgtttatcatgtttccc	7	14	5	15	0	1	0	1	0	0	0	4	0	4	0	4	0	3	4	4	0	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:55615418C>T	uc010spf.1	+	1	610	c.610C>T	c.(610-612)CTC>TTC	p.L204F		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						TGCCTCCACACTCCTGTTTAT	0.463													25	63					0	0	0	0	T	55615418	T	T	55615418	3	4	234	1	0	0	0	0	1	0	0	0	10949	565	20	4	612	4	OR10A7	12	55615418	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1499538	55615418	78236477	202	42414											
SLC16A7	9194	broad.mit.edu	37	chr12	60169129	60169129	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtattttttggccttggattTgggagtgttagcagtgttct	5	19	13	4	0	1	0	0	0	1	0	1	2	1	2	1	3	1	4	1	3	2	8			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:60169129T>C	uc001sqs.2	+	5	1352	c.1053T>C	c.(1051-1053)TTT>TTC	p.F351F	SLC16A7_uc001sqt.2_Silent_p.F351F|SLC16A7_uc001squ.2_Silent_p.F351F|SLC16A7_uc009zqi.2_Silent_p.F252F|SLC16A7_uc010ssi.1_Silent_p.F252F	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	351	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	GCCTTGGATTTGGGAGTGTTA	0.478													4	169					0	0	0	0	C	60169129	C	C	60169129	2	2	234	1	0	0	0	0	0	0	0	1	14478	1809	63	5		5	SLC16A7	12	60169129	Silent	SNP	T	TCGA-CV-7242-01A-11D-2012-08	4553711	60169129	73682766	203	42415											
RASSF3	283349	broad.mit.edu	37	chr12	65085357	65085357	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcgtgaacatgaaattggaGaggtaagttattgttcacta	13	14	10	4	1	1	3	1	2	0	1	2	4	1	3	0	2	1	3	0	2	5	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:65085357G>A	uc001ssd.2	+	4	685	c.565G>A	c.(565-567)GAG>AAG	p.E189K	RASSF3_uc009zqn.2_RNA|RASSF3_uc001sse.2_Missense_Mutation_p.E119K	NM_178169	NP_835463	Q86WH2	RASF3_HUMAN	Ras association (RalGDS/AF-6) domain family	189	SARAH.				signal transduction	cytoplasm|microtubule	identical protein binding				0			Lung(2;0.00133)|LUAD - Lung adenocarcinoma(6;0.0665)|LUSC - Lung squamous cell carcinoma(43;0.132)	GBM - Glioblastoma multiforme(28;0.0611)		TGAAATTGGAGAGGTAAGTTA	0.413													6	23					0	0	0	0	A	65085357	A	A	65085357	3	1	234	1	0	0	0	0	1	0	0	0	13152	943	33	2	579	2	RASSF3	12	65085357	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	4916228	65085357	68766538	204	42416											
NAV3	89795	broad.mit.edu	37	chr12	78400711	78400711	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ataaaaagtctttgctacagCcaaaggaaaaagaagaaaag	22	6	8	5	0	1	2	0	0	1	2	1	3	1	3	1	1	3	1	1	1	10	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:78400711C>A	uc001syp.2	+	8	1566	c.1393C>A	c.(1393-1395)CCA>ACA	p.P465T	NAV3_uc001syo.2_Missense_Mutation_p.P465T	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	465						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TTTGCTACAGCCAAAGGAAAA	0.408										HNSCC(70;0.22)			12	56					2.80697e-09	6.135e-09	1	0	A	78400711	A	A	78400711	3	1	234	1	0	0	0	0	1	0	0	0	10238	739	26	4	1423	4	NAV3	12	78400711	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	13315354	78400711	55451184	205	42417											
CEP290	80184	broad.mit.edu	37	chr12	88487640	88487640	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attttttgacaatgttcagcCcgctgcctttcatttaattc	8	18	5	10	1	2	1	2	1	0	0	3	1	2	1	2	0	2	2	2	0	2	8			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:88487640C>A	uc001tar.2	-	28	3560	c.3216G>T	c.(3214-3216)CGG>CGT	p.R1072R	CEP290_uc001taq.2_Silent_p.R132R|CEP290_uc001tat.2_Silent_p.R865R	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1072	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						AATGTTCAGCCCGCTGCCTTT	0.348													14	28					4.3838e-07	9.16955e-07	1	0	A	88487640	A	A	88487640	2	1	234	1	0	0	0	0	0	0	0	1	3268	610	22	4		4	CEP290	12	88487640	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	10086929	88487640	45364255	206	42418											
ANKS1B	56899	broad.mit.edu	37	chr12	99793503	99793503	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtaaagcttgtgcacccTgtagatgtgttgatttcaaa	11	13	10	7	0	1	2	1	1	0	1	1	2	1	2	1	0	2	6	1	0	4	5	rs34594552		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:99793503T>A	uc001tge.1	-	12	2079	c.1662A>T	c.(1660-1662)ACA>ACT	p.T554T	ANKS1B_uc001tgf.1_Silent_p.T134T|ANKS1B_uc009ztt.1_Silent_p.T520T	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	554						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TTGTGCACCCTGTAGATGTGT	0.428													24	69					0	0	0	0	A	99793503	A	A	99793503	2	1	234	1	0	0	0	0	0	0	0	1	689	1567	55	5		5	ANKS1B	12	99793503	Silent	SNP	T	TCGA-CV-7242-01A-11D-2012-08	11305863	99793503	34058392	207	42419											
DEPDC4	120863	broad.mit.edu	37	chr12	100657483	100657483	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaacccctttaagacaagAgatgtcattgctacttaggc	13	11	8	9	0	1	3	1	1	0	2	1	4	1	3	2	1	3	1	2	1	5	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:100657483A>G	uc001thi.2	-	2	349	c.346T>C	c.(346-348)TCT>CCT	p.S116P	DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Intron|DEPDC4_uc009ztv.1_Missense_Mutation_p.S116P|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	116	DEP.				intracellular signal transduction						0						TTAAGACAAGAGATGTCATTG	0.363													23	77					0	0	0	0	G	100657483	G	G	100657483	3	3	234	1	0	0	0	0	1	0	0	0	4463	304	11	5	554	5	DEPDC4	12	100657483	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	863980	100657483	33194412	208	42420											
ANO4	121601	broad.mit.edu	37	chr12	101442142	101442142	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccacctttttgacaatggAgccactgtcttctttgctgt	7	15	7	12	0	2	1	0	1	2	0	2	2	2	2	3	1	2	1	3	1	1	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:101442142A>T	uc010svm.1	+	14	1847	c.1275A>T	c.(1273-1275)GGA>GGT	p.G425G	ANO4_uc001thw.2_Silent_p.G390G|ANO4_uc001thx.2_Silent_p.G425G|ANO4_uc001thy.2_5'UTR	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	425	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTGACAATGGAGCCACTGTCT	0.348										HNSCC(74;0.22)			13	42					0	0	0	0	T	101442142	T	T	101442142	2	4	234	1	0	0	0	0	0	0	0	1	699	291	11	5		5	ANO4	12	101442142	Silent	SNP	A	TCGA-CV-7242-01A-11D-2012-08	784659	101442142	32409753	209	42421											
CCDC53	51019	broad.mit.edu	37	chr12	102433723	102433723	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttctgctgatacttcacTttcctgtagtccagagtctt	7	18	6	10	0	3	2	1	1	2	1	5	2	5	2	2	0	2	2	2	0	2	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:102433723T>C	uc010svw.1	-	5	517	c.358A>G	c.(358-360)AGT>GGT	p.S120G	CCDC53_uc010svx.1_RNA|CCDC53_uc010svy.1_RNA|CCDC53_uc010svz.1_Missense_Mutation_p.S119G	NM_016053	NP_057137	Q9Y3C0	CCD53_HUMAN	coiled-coil domain containing 53	120						WASH complex	protein binding				0						GATACTTCACTTTCCTGTAGT	0.373													37	130					0	0	0	0	C	102433723	C	C	102433723	3	2	234	1	0	0	0	0	1	0	0	0	2836	1609	56	5	169	5	CCDC53	12	102433723	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	991581	102433723	31418172	210	42422											
SLC41A2	84102	broad.mit.edu	37	chr12	105260336	105260336	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaaaaatacaccaactaatGgagaaatgtagtaataggtc	20	8	8	5	0	0	2	0	0	0	2	1	3	0	2	1	2	2	2	1	2	9	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:105260336G>A	uc001tla.2	-	6	1216	c.1049C>T	c.(1048-1050)CCA>CTA	p.P350L		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	350	Helical; (Potential).					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						ACCAACTAATGGAGAAATGTA	0.343													16	73					0	0	0	0	A	105260336	A	A	105260336	3	1	234	1	0	0	0	0	1	0	0	0	14694	1348	47	4	692	4	SLC41A2	12	105260336	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2826613	105260336	28591559	211	42423											
C12orf51	283450	broad.mit.edu	37	chr12	112605241	112605241	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcaggaggtccaggggcagCgggacgtctgcccgaattgc	7	5	18	11	3	1	0	0	0	1	0	2	3	2	2	2	6	3	2	2	6	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:112605241C>G	uc009zwc.2	-	65	11166	c.11148G>C	c.(11146-11148)CCG>CCC	p.P3716P		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CCAGGGGCAGCGGGACGTCTG	0.622													17	57					0	0	0	0	G	112605241	G	G	112605241	2	3	234	1	0	0	0	0	0	0	0	1	1702	755	27	3		3	C12orf51	12	112605241	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	7344905	112605241	21246654	212	42424											
RASAL1	8437	broad.mit.edu	37	chr12	113541858	113541858	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctggccttgcgcaaggccGagagccactggttgagctca	7	7	14	13	3	1	2	1	1	0	1	1	3	1	2	3	3	3	4	3	3	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:113541858G>T	uc001tum.1	-	19	2287	c.1994C>A	c.(1993-1995)TCG>TAG	p.S665*	RASAL1_uc010syp.1_Nonsense_Mutation_p.S666*|RASAL1_uc001tul.2_Nonsense_Mutation_p.S637*|RASAL1_uc001tun.1_Nonsense_Mutation_p.S667*|RASAL1_uc010syq.1_Nonsense_Mutation_p.S666*|RASAL1_uc001tuo.3_Nonsense_Mutation_p.S666*	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	665	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						GCGCAAGGCCGAGAGCCACTG	0.711													3	15					6.4e-05	0.00012627	1	0	T	113541858	T	T	113541858	4	4	234	1	0	0	0	0	0	1	0	0	13128	1059	37	3	436	3	RASAL1	12	113541858	Nonsense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	936617	113541858	20310037	213	42425											
WDR66	144406	broad.mit.edu	37	chr12	122396265	122396265	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagttatttgtagagcccaaGgatgccatttgtgccatctc	10	13	9	9	0	1	1	0	0	1	1	2	2	1	2	3	1	3	2	3	1	4	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:122396265G>A	uc009zxk.2	+	12	1960	c.1818G>A	c.(1816-1818)AAG>AAA	p.K606K		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	606	WD 6.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		TAGAGCCCAAGGATGCCATTT	0.448													40	134					0	0	0	0	A	122396265	A	A	122396265	2	1	234	1	0	0	0	0	0	0	0	1	17385	991	35	4		4	WDR66	12	122396265	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	8854407	122396265	11455630	214	42426											
CHFR	55743	broad.mit.edu	37	chr12	133435715	133435715	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcgtctcctccatcttgtCtggcttcccagccgctgctc	3	12	8	18	2	3	0	0	0	3	0	7	0	5	0	4	1	3	3	4	1	0	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:133435715C>T	uc001ulf.2	-	8	970	c.886G>A	c.(886-888)GAC>AAC	p.D296N	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Missense_Mutation_p.D284N|CHFR_uc010tbs.1_Missense_Mutation_p.D296N|CHFR_uc001uld.2_Missense_Mutation_p.D255N|CHFR_uc010tbt.1_Missense_Mutation_p.D204N	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	296					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TCCATCTTGTCTGGCTTCCCA	0.597													13	42					0	0	0	0	T	133435715	T	T	133435715	3	4	234	1	0	0	0	0	1	0	0	0	3352	913	32	2	1152	2	CHFR	12	133435715	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	11039450	133435715	416180	215	42427											
ZNF140	7699	broad.mit.edu	37	chr12	133682776	133682776	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaccttatgaatgcattGaatgtgggaaggcatttcgc	13	11	11	6	1	0	3	0	2	0	1	1	4	0	4	1	2	2	2	1	2	5	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr12:133682776G>T	uc001ulo.2	+	5	1583	c.913G>T	c.(913-915)GAA>TAA	p.E305*	ZNF140_uc001ulp.2_Nonsense_Mutation_p.E202*|ZNF140_uc010tbu.1_Nonsense_Mutation_p.E202*	NM_003440	NP_003431	P52738	ZN140_HUMAN	zinc finger protein 140	305	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.114)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TGAATGCATTGAATGTGGGAA	0.408													20	48					2.94398e-08	6.26562e-08	1	0	T	133682776	T	T	133682776	4	4	234	1	0	0	0	0	0	1	0	0	17796	1291	45	2	927	2	ZNF140	12	133682776	Nonsense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	247061	133682776	169119	216	42428											
TNFRSF19	55504	broad.mit.edu	37	chr13	24200851	24200851	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcctttctcttctagattttAtaggaagacgaaacttgtcg	10	16	7	8	2	2	2	0	0	2	2	5	4	3	3	1	1	1	0	1	1	5	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr13:24200851A>G	uc001uov.1	+	5	429	c.365A>G	c.(364-366)TAT>TGT	p.Y122C	TNFRSF19_uc001uot.2_Missense_Mutation_p.Y122C|TNFRSF19_uc010tcu.1_5'UTR|TNFRSF19_uc001uow.2_Missense_Mutation_p.Y122C	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	122	Extracellular (Potential).|TNFR-Cys 3.				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TCTAGATTTTATAGGAAGACG	0.443													14	33					0	0	0	0	G	24200851	G	G	24200851	3	3	234	1	0	0	0	0	1	0	0	0	16358	449	16	5	379	5	TNFRSF19	13	24200851	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08		24200851	90969027	217	42429											
HSPH1	10808	broad.mit.edu	37	chr13	31711555	31711555	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttttgtcttctaaatctTcttcctttttatcaatattt	7	25	2	7	0	5	0	1	0	4	0	6	0	6	0	1	0	0	1	1	0	5	11			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr13:31711555T>C	uc001utj.2	-	18	2875	c.2477A>G	c.(2476-2478)GAA>GGA	p.E826G	HSPH1_uc001utk.2_Missense_Mutation_p.E782G|HSPH1_uc010aaw.2_Missense_Mutation_p.E785G|HSPH1_uc001utl.2_Missense_Mutation_p.E828G|HSPH1_uc010tds.1_Missense_Mutation_p.E750G	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	826					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TTCTAAATCTTCTTCCTTTTT	0.363													19	47					0	0	0	0	C	31711555	C	C	31711555	3	2	234	1	0	0	0	0	1	0	0	0	7470	1783	62	5	103	5	HSPH1	13	31711555	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	7510704	31711555	83458323	218	42430											
CPB2	1361	broad.mit.edu	37	chr13	46661882	46661882	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattagggagaaattacctCatatgttgtagtaagattct	15	14	8	4	0	2	2	1	0	1	2	2	3	2	2	1	1	1	3	1	1	7	7			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr13:46661882C>A	uc001vaw.2	-	2	215	c.148G>T	c.(148-150)GAG>TAG	p.E50*	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Nonsense_Mutation_p.E50*	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	50					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		GAAATTACCTCATATGTTGTA	0.378													28	37					2.61193e-14	6.27207e-14	1	0	A	46661882	A	A	46661882	4	1	234	1	0	0	0	0	0	1	0	0	3812	835	29	2	1163	2	CPB2	13	46661882	Nonsense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	14950327	46661882	68507996	219	42431											
TEP1	7011	broad.mit.edu	37	chr14	20874489	20874489	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctccacctcctcctcctctCccaagctcagactataagaa	10	9	3	19	0	2	2	1	0	1	2	7	2	6	2	7	0	1	1	7	0	4	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr14:20874489C>T	uc001vxe.2	-	3	678	c.638G>A	c.(637-639)GGA>GAA	p.G213E	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.G213E	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	213					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CTCCTCCTCTCCCAAGCTCAG	0.502													25	82					0	0	0	0	T	20874489	T	T	20874489	3	4	234	1	0	0	0	0	1	0	0	0	15825	855	30	2	7457	2	TEP1	14	20874489	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08		20874489	86475051	220	42432											
CPNE6	9362	broad.mit.edu	37	chr14	24543809	24543809	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggaccaaagtgatcagctgGtctggagaactgaggttggt	11	9	15	6	0	2	3	1	2	1	1	2	5	2	4	1	5	2	2	1	5	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr14:24543809G>C	uc001wll.2	+	6	667	c.568G>C	c.(568-570)GTC>CTC	p.V190L	CPNE6_uc010tnv.1_Missense_Mutation_p.V245L|CPNE6_uc001wlm.2_Missense_Mutation_p.V15L|CPNE6_uc001wln.2_5'Flank	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	190	C2 2.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		TGATCAGCTGGTCTGGAGAAC	0.517													8	60					0	0	0	0	C	24543809	C	C	24543809	3	2	234	1	0	0	0	0	1	0	0	0	3831	1261	44	4	586	4	CPNE6	14	24543809	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	3669320	24543809	82805731	221	42433											
CFL2	1073	broad.mit.edu	37	chr14	35183682	35183682	+	5'Flank	DEL	G	-	-																															aaaatggcggcctcactcccGgggccgtgcggggggctttt																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr14:35183682delG	uc001wsg.3	-						CFL2_uc010tpn.1_5'UTR|CFL2_uc001wsh.3_Intron|CFL2_uc001wsi.3_Intron|CFL2_uc001wsj.3_Intron	NM_021914	NP_068733	Q9Y281	COF2_HUMAN	cofilin 2							cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(2)	2	Breast(36;0.0361)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;6.07e-06)|Lung(238;2.23e-05)|Epithelial(34;0.0387)|all cancers(34;0.0814)	GBM - Glioblastoma multiforme(112;0.0424)		CCTCACTCCCGGGGCCGTGCG	0.716													---	---	---								-	35183682	-	-	35183682	6	5	234	0	1	1	0	1	0	0	0	0	3306	1131	39	0		0	CFL2	14	35183682	5'Flank	DEL	G	TCGA-CV-7242-01A-11D-2012-08	10639873	35183682	72165858	222	42434											
SYT16	83851	broad.mit.edu	37	chr14	62547693	62547693	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagggcacagggcctcccaGataaggaccgaagtggtgtc	10	6	15	10	1	0	2	0	1	0	1	2	4	1	3	3	4	0	1	3	4	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr14:62547693G>C	uc001xfu.1	+	4	1332	c.1135G>C	c.(1135-1137)GAT>CAT	p.D379H	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_5'UTR	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	379	C2 1.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GGGCCTCCCAGATAAGGACCG	0.537													5	18					0	0	0	0	C	62547693	C	C	62547693	3	2	234	1	0	0	0	0	1	0	0	0	15538	942	33	2	1149	2	SYT16	14	62547693	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	27364011	62547693	44801847	223	42435											
AHSA1	10598	broad.mit.edu	37	chr14	77929012	77929012	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgagccttgccaaagatgagCctgacacaaatctcgtggcc	11	8	10	12	1	1	4	0	3	1	1	2	4	1	4	4	1	3	0	4	1	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr14:77929012C>T	uc001xtw.2	+	4	542	c.382C>T	c.(382-384)CCT>TCT	p.P128S	AHSA1_uc010tvk.1_Missense_Mutation_p.P128S	NM_012111	NP_036243	O95433	AHSA1_HUMAN	activator of heat shock 90kDa protein ATPase	128					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		CAAAGATGAGCCTGACACAAA	0.463													19	63					0	0	0	0	T	77929012	T	T	77929012	3	4	234	1	0	0	0	0	1	0	0	0	418	739	26	4	396	4	AHSA1	14	77929012	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	15381319	77929012	29420528	224	42436											
GALC	2581	broad.mit.edu	37	chr14	88401201	88401201	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccacagagacttgtcattcaGcatgccagaggtgaaatgac	13	8	10	10	0	2	4	2	2	0	2	2	5	2	4	2	1	2	1	2	1	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr14:88401201G>C	uc001xvt.2	-	17	2332	c.1933C>G	c.(1933-1935)CTG>GTG	p.L645V	GALC_uc010tvw.1_Intron|GALC_uc010tvx.1_Missense_Mutation_p.L619V|GALC_uc010tvy.1_Missense_Mutation_p.L622V|GALC_uc010tvz.1_Intron	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	645			L -> R (in GLD; adult).		carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						TTGTCATTCAGCATGCCAGAG	0.428													10	30					0	0	0	0	C	88401201	C	C	88401201	3	2	234	1	0	0	0	0	1	0	0	0	6236	962	34	4	128	4	GALC	14	88401201	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	10472189	88401201	18948339	225	42437											
TTC7B	145567	broad.mit.edu	37	chr14	91084371	91084371	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggcagagtgactgcaacttCactttggaaaacagtagtct	12	10	10	9	1	2	2	1	1	1	1	2	3	2	3	0	2	3	3	0	2	4	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr14:91084371C>T	uc001xyp.2	-	16	1892	c.1770G>A	c.(1768-1770)GTG>GTA	p.V590V	TTC7B_uc001xyo.2_Silent_p.V17V|TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	590							binding			ovary(2)	2		Melanoma(154;0.222)				ACTGCAACTTCACTTTGGAAA	0.542													19	38					0	0	0	0	T	91084371	T	T	91084371	2	4	234	1	0	0	0	0	0	0	0	1	16781	813	29	2		2	TTC7B	14	91084371	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	2683170	91084371	16265169	226	42438											
RIN3	79890	broad.mit.edu	37	chr14	93125658	93125658	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccaccaccaccactgacCtaggtgtgaccaccagcgtg	9	6	10	16	1	0	2	0	2	0	0	0	2	0	2	7	2	1	0	7	2	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr14:93125658C>G	uc001yap.2	+	7	2331	c.2179C>G	c.(2179-2181)CTA>GTA	p.L727V	RIN3_uc010auk.2_Missense_Mutation_p.L389V|RIN3_uc001yaq.2_Missense_Mutation_p.L652V|RIN3_uc001yar.1_Missense_Mutation_p.L389V|RIN3_uc001yas.1_Missense_Mutation_p.L389V	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	727	Interaction with RAB5B.|VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CACCACTGACCTAGGTGTGAC	0.552													33	102					0	0	0	0	G	93125658	G	G	93125658	3	3	234	1	0	0	0	0	1	0	0	0	13438	680	24	4	2205	4	RIN3	14	93125658	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	2041287	93125658	14223882	227	42439											
AHNAK2	113146	broad.mit.edu	37	chr14	105410214	105410214	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgagcttggaccgtcaggtcGgcagaatggggctgaatgct	8	8	16	9	3	1	2	1	1	0	1	2	4	1	3	1	5	2	4	1	5	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr14:105410214G>A	uc010axc.1	-	7	11694	c.11574C>T	c.(11572-11574)GCC>GCT	p.A3858A	AHNAK2_uc001ypx.2_Silent_p.A3758A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3858						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCGTCAGGTCGGCAGAATGGG	0.632													60	193					0	0	0	0	A	105410214	A	A	105410214	2	1	234	1	0	0	0	0	0	0	0	1	415	1103	39	1		1	AHNAK2	14	105410214	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	12284556	105410214	1939326	228	42440											
NIPA1	123606	broad.mit.edu	37	chr15	23049038	23049038	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgacgtagtagatggcccCgaacaccgaggagtcgaagc	12	4	13	12	5	0	1	0	0	0	1	1	6	0	2	3	2	2	2	3	2	4	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:23049038C>A	uc001yvc.2	-	5	806	c.781G>T	c.(781-783)GGG>TGG	p.G261W	NIPA1_uc001yvd.2_Missense_Mutation_p.G91W|NIPA1_uc001yve.2_Missense_Mutation_p.G186W	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	261	Helical; (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		TAGATGGCCCCGAACACCGAG	0.607													12	21					0.00010058	0.000195796	1	0	A	23049038	A	A	23049038	3	1	234	1	0	0	0	0	1	0	0	0	10476	652	23	3	212	3	NIPA1	15	23049038	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08		23049038	79482354	229	42441											
MKRN3	7681	broad.mit.edu	37	chr15	23811310	23811310	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttctggtcggaagatggcCactgagggtggcgtttcgcc	5	11	15	10	3	1	2	0	1	1	1	3	3	1	3	2	5	0	1	2	5	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:23811310C>G	uc001ywh.3	+	1	857	c.381C>G	c.(379-381)GCC>GCG	p.A127A	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Silent_p.A127A	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	127						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GGAAGATGGCCACTGAGGGTG	0.607													23	34					0	0	0	0	G	23811310	G	G	23811310	2	3	234	1	0	0	0	0	0	0	0	1	9661	581	21	4		4	MKRN3	15	23811310	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	762272	23811310	78720082	230	42442											
GABRA5	2558	broad.mit.edu	37	chr15	27185148	27185148	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatccagacctaccttccCtgcataatgaccgtgatctt	9	12	6	14	1	2	3	1	2	1	1	4	3	4	3	5	0	2	1	5	0	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:27185148C>G	uc001zbd.1	+	10	1140	c.801C>G	c.(799-801)CCC>CCG	p.P267P	GABRB3_uc001zbb.2_5'Flank	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	267	Helical; (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CCTACCTTCCCTGCATAATGA	0.493													11	16					0	0	0	0	G	27185148	G	G	27185148	2	3	234	1	0	0	0	0	0	0	0	1	6198	668	24	4		4	GABRA5	15	27185148	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	3373838	27185148	75346244	231	42443											
MTMR10	54893	broad.mit.edu	37	chr15	31253125	31253125	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcgttaatagaacaaactctCcacccggaagcacctgtcct	12	9	6	14	2	1	1	0	0	1	1	4	2	2	2	4	1	3	2	4	1	5	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:31253125C>A	uc001zfh.1	-	7	815	c.717G>T	c.(715-717)TGG>TGT	p.W239C	MTMR10_uc010azx.1_5'UTR|MTMR10_uc001zfi.1_5'UTR|MTMR10_uc001zfj.2_Missense_Mutation_p.W157C|MTMR10_uc001zfk.2_5'UTR|MTMR10_uc010ubl.1_RNA	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	239	Myotubularin phosphatase.						phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		AACAAACTCTCCACCCGGAAG	0.418													7	15					1.12685e-05	2.2537e-05	1	0	A	31253125	A	A	31253125	3	1	234	1	0	0	0	0	1	0	0	0	9992	856	30	2	1656	2	MTMR10	15	31253125	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	4067977	31253125	71278267	232	42444											
CHRNA7	1139	broad.mit.edu	37	chr15	32460234	32460234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggcctgccagcacaagcagCggcgctgcagcctggccagt	7	4	14	16	3	0	0	0	0	0	0	0	0	0	0	4	3	6	4	4	3	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:32460234C>T	uc001zft.2	+	10	1156	c.1084C>T	c.(1084-1086)CGG>TGG	p.R362W	uc001zfv.1_Intron|CHRNA7_uc010baf.2_Missense_Mutation_p.R181W|CHRNA7_uc010bak.2_Missense_Mutation_p.R277W	NM_000746	NP_000737	P36544	ACHA7_HUMAN	cholinergic receptor, nicotinic, alpha 7	362	Cytoplasmic (Potential).				activation of MAPK activity|calcium ion transport|cellular calcium ion homeostasis|memory|negative regulation of tumor necrosis factor production|positive regulation of angiogenesis|positive regulation of cell proliferation|response to hypoxia|response to nicotine	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|beta-amyloid binding|chloride channel regulator activity|nicotinic acetylcholine-activated cation-selective channel activity|protein homodimerization activity|toxin binding			ovary(1)	1		all_lung(180;6.35e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)	Nicotine(DB00184)|Varenicline(DB01273)	GCACAAGCAGCGGCGCTGCAG	0.687													17	43					0	0	0	0	T	32460234	T	T	32460234	3	4	234	1	0	0	0	0	1	0	0	0	3403	759	27	1	1122	1	CHRNA7	15	32460234	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1207109	32460234	70071158	233	42445											
C15orf55	256646	broad.mit.edu	37	chr15	34646693	34646693	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagacacgggccccccgccgGcgtcagcgtaaagcccagag	10	2	13	16	5	1	2	1	0	0	2	1	2	1	2	5	2	2	1	5	2	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:34646693G>C	uc001zif.2	+	5	1193	c.1038G>C	c.(1036-1038)CGG>CGC	p.R346R	C15orf55_uc010ucc.1_Silent_p.R374R|C15orf55_uc010ucd.1_Silent_p.R364R	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	346						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CCCCCCGCCGGCGTCAGCGTA	0.557			T	BRD3|BRD4	lethal midline carcinoma								23	62					0	0	0	0	C	34646693	C	C	34646693	2	2	234	1	0	0	0	0	0	0	0	1	1809	1190	42	4		4	C15orf55	15	34646693	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2186459	34646693	67884699	234	42446											
LCMT2	9836	broad.mit.edu	37	chr15	43621835	43621835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcaatattttccacccgccGgcgttcttctgcgggaagaa	8	12	9	12	4	3	1	1	0	2	1	4	2	4	2	3	2	1	1	3	2	4	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:43621835G>A	uc001zrg.2	-	1	1057	c.853C>T	c.(853-855)CGG>TGG	p.R285W	LCMT2_uc010udn.1_5'UTR|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	285					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	TCCACCCGCCGGCGTTCTTCT	0.557													14	34					0	0	0	0	A	43621835	A	A	43621835	3	1	234	1	0	0	0	0	1	0	0	0	8719	1115	39	1	1211	1	LCMT2	15	43621835	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	8975142	43621835	58909557	235	42447											
CATSPER2	117155	broad.mit.edu	37	chr15	43928002	43928002	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atctcctcattcagctctttCctgatattctgaaagttagt	9	17	5	10	0	5	2	2	2	3	0	7	2	6	2	2	0	1	2	2	0	3	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:43928002C>A	uc001zsh.2	-	9	1259	c.1044G>T	c.(1042-1044)AGG>AGT	p.R348S	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Missense_Mutation_p.R348S|CATSPER2_uc001zsj.2_Missense_Mutation_p.R348S	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	348	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TCAGCTCTTTCCTGATATTCT	0.512													13	20					0.00244969	0.00458533	1	0	A	43928002	A	A	43928002	3	1	234	1	0	0	0	0	1	0	0	0	2700	854	30	2	568	2	CATSPER2	15	43928002	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	306167	43928002	58603390	236	42448											
TEX9	374618	broad.mit.edu	37	chr15	56683602	56683602	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tattttttctggtgttagtaAtgacattggaacaggtagat	11	17	10	3	0	1	2	0	1	1	1	1	3	1	3	0	3	1	3	0	3	5	8			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:56683602A>T	uc002adp.2	+	7	562	c.557A>T	c.(556-558)AAT>ATT	p.N186I	TEX9_uc002ado.1_Missense_Mutation_p.N186I|TEX9_uc010ugl.1_Missense_Mutation_p.N111I|TEX9_uc002adq.1_Missense_Mutation_p.N111I	NM_198524	NP_940926	Q8N6V9	TEX9_HUMAN	testis expressed 9	186											0				all cancers(107;0.0394)|GBM - Glioblastoma multiforme(80;0.056)		GGTGTTAGTAATGACATTGGA	0.313													11	27					0	0	0	0	T	56683602	T	T	56683602	3	4	234	1	0	0	0	0	1	0	0	0	15850	101	4	5	583	5	TEX9	15	56683602	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	12755600	56683602	45847790	237	42449											
VPS13C	54832	broad.mit.edu	37	chr15	62242607	62242607	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttttaaattctggtccatCactgtctgcctacaaatagt	11	15	6	9	0	3	0	1	0	2	0	4	0	4	0	2	1	2	1	2	1	5	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:62242607C>A	uc002agz.2	-	41	4620	c.4546G>T	c.(4546-4548)GAT>TAT	p.D1516Y	VPS13C_uc002aha.2_Missense_Mutation_p.D1473Y|VPS13C_uc002ahb.1_Missense_Mutation_p.D1516Y|VPS13C_uc002ahc.1_Missense_Mutation_p.D1473Y	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1516					protein localization					ovary(2)	2						TCTGGTCCATCACTGTCTGCC	0.313													5	15					0.000602214	0.00114483	1	0	A	62242607	A	A	62242607	3	1	234	1	0	0	0	0	1	0	0	0	17259	826	29	2	6923	2	VPS13C	15	62242607	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	5559005	62242607	40288785	238	42450											
MEGF11	84465	broad.mit.edu	37	chr15	66249955	66249955	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgccattctgacaggtgcaaGgcagctggcagccatcgcca	9	6	12	14	2	1	1	0	1	1	0	2	1	1	1	3	3	3	4	3	3	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:66249955G>T	uc002apm.2	-	10	1358	c.1217C>A	c.(1216-1218)CCT>CAT	p.P406H	MEGF11_uc002apl.2_Missense_Mutation_p.P331H|MEGF11_uc002apn.1_Missense_Mutation_p.P406H	NM_032445	NP_115821	A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11 precursor	406	EGF-like 7.					basolateral plasma membrane|integral to membrane				pancreas(1)	1						ACAGGTGCAAGGCAGCTGGCA	0.612													9	19					1.12685e-05	2.2537e-05	1	0	T	66249955	T	T	66249955	3	4	234	1	0	0	0	0	1	0	0	0	9514	1000	35	4	1973	4	MEGF11	15	66249955	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	4007348	66249955	36281437	239	42451											
SGK269	79834	broad.mit.edu	37	chr15	77425541	77425541	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtttcttcaaggcatctgTatgaaggcttcggattttac	9	15	9	8	1	3	1	1	1	2	0	4	2	3	2	0	3	1	4	0	3	4	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:77425541T>A	uc002bcm.2	-	5	4191	c.3883A>T	c.(3883-3885)ACA>TCA	p.T1295S		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1295					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		AAGGCATCTGTATGAAGGCTT	0.507													41	110					0	0	0	0	A	77425541	A	A	77425541	3	1	234	1	0	0	0	0	1	0	0	0	14276	1638	57	5	1365	5	SGK269	15	77425541	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	11175586	77425541	25105851	240	42452											
NTRK3	4916	broad.mit.edu	37	chr15	88669548	88669548	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatatttgttgatcatgacGaagagaaccaccaacaggac	15	8	8	10	1	1	3	1	2	0	1	1	6	1	4	3	1	2	1	3	1	4	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:88669548G>A	uc002bme.1	-	12	1512	c.1350C>T	c.(1348-1350)TTC>TTT	p.F450F	NTRK3_uc002bmh.2_Silent_p.F442F|NTRK3_uc002bmf.1_Silent_p.F450F|NTRK3_uc010upl.1_Silent_p.F352F|NTRK3_uc010bnh.1_Silent_p.F442F|NTRK3_uc002bmg.2_Silent_p.F450F	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	450	Helical; (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGATCATGACGAAGAGAACCA	0.453			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			12	27					0	0	0	0	A	88669548	A	A	88669548	2	1	234	1	0	0	0	0	0	0	0	1	10762	1049	37	1		1	NTRK3	15	88669548	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	11244007	88669548	13861844	241	42453											
IGF1R	3480	broad.mit.edu	37	chr15	99251053	99251053	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaactacgccctggtcatCttcgagatgaccaatctcaa	12	10	6	13	2	3	2	2	1	2	1	5	3	3	2	2	1	3	0	2	1	5	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr15:99251053C>A	uc002bul.2	+	2	407	c.357C>A	c.(355-357)ATC>ATA	p.I119I	IGF1R_uc010urq.1_Silent_p.I119I|IGF1R_uc010bon.2_Silent_p.I119I	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	119					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CCCTGGTCATCTTCGAGATGA	0.532													32	28					2.81731e-10	6.3673e-10	1	0	A	99251053	A	A	99251053	2	1	234	1	0	0	0	0	0	0	0	1	7610	903	32	2		2	IGF1R	15	99251053	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	10581505	99251053	3280339	242	42454											
ABAT	18	broad.mit.edu	37	chr16	8851634	8851634	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttacagccaccccgccctgCtgaaactcatccaacagcct	10	7	6	18	1	1	1	1	1	0	0	2	1	2	1	6	0	6	2	6	0	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:8851634C>G	uc002czc.3	+	6	503	c.337C>G	c.(337-339)CTG>GTG	p.L113V	ABAT_uc002czd.3_Missense_Mutation_p.L113V|ABAT_uc010buh.2_Missense_Mutation_p.L55V|ABAT_uc010bui.2_Missense_Mutation_p.L113V	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	113				L -> V (in Ref. 1; AAA74449).	behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	CCCCGCCCTGCTGAAACTCAT	0.522													11	43					0	0	0	0	G	8851634	G	G	8851634	3	3	234	1	0	0	0	0	1	0	0	0	27	796	28	4	355	4	ABAT	16	8851634	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08		8851634	81503119	243	42455											
ANKS4B	257629	broad.mit.edu	37	chr16	21261971	21261971	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcacctggaagaattcctgCctatcttcaagagagagcag	13	8	10	10	0	2	3	1	0	1	3	3	5	3	4	3	1	3	2	3	1	4	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:21261971C>T	uc010bwp.1	+	2	1127	c.1084C>T	c.(1084-1086)CCT>TCT	p.P362S	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	362	SAM.									ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		AGAATTCCTGCCTATCTTCAA	0.522													17	40					0	0	0	0	T	21261971	T	T	21261971	3	4	234	1	0	0	0	0	1	0	0	0	691	739	26	4	1090	4	ANKS4B	16	21261971	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	12410337	21261971	69092782	244	42456											
SRCAP	10847	broad.mit.edu	37	chr16	30745886	30745886	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catccgtgccctctgcccctGaagaggaggaagagactgtg	9	7	13	12	1	1	3	0	1	1	2	2	6	2	5	4	2	2	0	4	2	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:30745886G>A	uc002dze.1	+	31	7064	c.6679G>A	c.(6679-6681)GAA>AAA	p.E2227K	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.E2022K	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2227	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CTCTGCCCCTGAAGAGGAGGA	0.498													35	93					0	0	0	0	A	30745886	A	A	30745886	3	1	234	1	0	0	0	0	1	0	0	0	15201	1291	45	2	6793	2	SRCAP	16	30745886	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	9483915	30745886	59608867	245	42457											
PYDC1	260434	broad.mit.edu	37	chr16	31228118	31228118	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgcggcctcctccaacaTgcgcatgtcgcgcagcacgg	6	6	12	17	6	0	0	0	0	0	0	3	0	2	0	4	2	4	3	4	2	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:31228118T>C	uc002ebo.2	-	1	281	c.232A>G	c.(232-234)ATG>GTG	p.M78V	TRIM72_uc002ebn.1_Intron	NM_152901	NP_690865	Q8WXC3	PYDC1_HUMAN	pyrin domain containing 1	78	DAPIN.				innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|positive regulation of interleukin-1 beta secretion|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex|nucleus	cysteine-type endopeptidase activity|protein binding				0						TCCTCCAACATGCGCATGTCG	0.662													16	53					0	0	0	0	C	31228118	C	C	31228118	3	2	234	1	0	0	0	0	1	0	0	0	12923	1464	51	5	41	5	PYDC1	16	31228118	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	482232	31228118	59126635	246	42458											
ITGAM	3684	broad.mit.edu	37	chr16	31340609	31340609	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagaataccagtcgggtcatGcagcatcaatatcaggtggg	12	8	13	8	1	3	1	3	0	0	1	4	2	3	1	1	3	3	2	1	3	4	2	rs61758333		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:31340609G>T	uc002ebq.2	+	24	2951	c.2853G>T	c.(2851-2853)ATG>ATT	p.M951I	ITGAM_uc002ebr.2_Missense_Mutation_p.M952I|ITGAM_uc010can.2_Missense_Mutation_p.M357I	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	951	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GTCGGGTCATGCAGCATCAAT	0.502													7	16					1.06961e-07	2.26324e-07	1	0	T	31340609	T	T	31340609	3	4	234	1	0	0	0	0	1	0	0	0	7926	1319	46	4	2950	4	ITGAM	16	31340609	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	112491	31340609	59014144	247	42459											
PRSS54	221191	broad.mit.edu	37	chr16	58325037	58325037	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggaagctttctggacgccaCaacctgcggagcaggtgcgg	8	6	15	12	4	1	0	0	0	1	0	1	3	1	3	2	5	5	2	2	5	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:58325037C>T	uc002enf.2	-	4	484	c.89G>A	c.(88-90)TGT>TAT	p.C30Y	PRSS54_uc002eng.2_Missense_Mutation_p.C30Y|PRSS54_uc010vie.1_Intron	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	30					proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CTGGACGCCACAACCTGCGGA	0.622													11	24					0	0	0	0	T	58325037	T	T	58325037	3	4	234	1	0	0	0	0	1	0	0	0	12695	478	17	4	1114	4	PRSS54	16	58325037	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	26984428	58325037	32029716	248	42460											
CNOT1	23019	broad.mit.edu	37	chr16	58568212	58568212	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgctcagcctgagcacGgtaactgatttcaacacaca	11	9	8	13	1	2	2	2	2	0	0	2	2	2	2	1	1	6	4	1	1	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:58568212G>A	uc002env.2	-	40	6027	c.5734C>T	c.(5734-5736)CGT>TGT	p.R1912C	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.R1907C|CNOT1_uc002ent.2_5'Flank|CNOT1_uc010vik.1_Missense_Mutation_p.R869C	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1912					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GCCTGAGCACGGTAACTGATT	0.478													9	37					0	0	0	0	A	58568212	A	A	58568212	3	1	234	1	0	0	0	0	1	0	0	0	3632	1116	39	1	1436	1	CNOT1	16	58568212	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	243175	58568212	31786541	249	42461											
CTCF	10664	broad.mit.edu	37	chr16	67660581	67660581	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcacacaagaatgagaagcGctttaagtgtgaccagtgtg	13	9	12	7	1	1	3	1	2	0	2	1	4	1	3	1	0	1	1	1	0	4	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:67660581G>T	uc002etl.2	+	8	1771	c.1481G>T	c.(1480-1482)CGC>CTC	p.R494L	CTCF_uc010cek.2_Missense_Mutation_p.R166L|CTCF_uc002etm.1_5'Flank	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	494					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		AATGAGAAGCGCTTTAAGTGT	0.453													10	38					4.68919e-08	9.9509e-08	1	0	T	67660581	T	T	67660581	3	4	234	1	0	0	0	0	1	0	0	0	4017	1087	38	3	1503	3	CTCF	16	67660581	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	9092369	67660581	22694172	250	42462											
CHST6	4166	broad.mit.edu	37	chr16	75513529	75513529	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgggctccattaggtagaaGacgtcggggtgctggttgaa	8	9	17	7	3	0	3	0	1	0	2	2	3	1	3	1	5	1	4	1	5	4	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:75513529G>C	uc002fef.2	-	3	378	c.198C>G	c.(196-198)GTC>GTG	p.V66V	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.V66V	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	66	Lumenal (Potential).		V -> L (in MCD).		keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						TTAGGTAGAAGACGTCGGGGT	0.687													14	37					0	0	0	0	C	75513529	C	C	75513529	2	2	234	1	0	0	0	0	0	0	0	1	3423	929	33	2		2	CHST6	16	75513529	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	7852948	75513529	14841224	251	42463											
ADAMTS18	170692	broad.mit.edu	37	chr16	77353779	77353779	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctcatttgtgggccctggCgcgtacagacgttccgggcg	4	10	15	12	5	1	1	1	0	1	1	3	1	2	1	2	3	1	2	2	3	1	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:77353779C>G	uc002ffc.3	-	16	2918	c.2499G>C	c.(2497-2499)GCG>GCC	p.A833A	ADAMTS18_uc010chc.1_Silent_p.A421A|ADAMTS18_uc002ffe.1_Silent_p.A529A	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	833	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TGGGCCCTGGCGCGTACAGAC	0.542													17	74					0	0	0	0	G	77353779	G	G	77353779	2	3	234	1	0	0	0	0	0	0	0	1	263	755	27	3		3	ADAMTS18	16	77353779	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1840250	77353779	13000974	252	42464											
CMIP	80790	broad.mit.edu	37	chr16	81712034	81712034	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggctcaagtcggtggtcGtggcctccagtgagatccac	6	8	13	14	3	1	1	1	1	0	1	5	2	3	1	4	4	0	1	4	4	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:81712034G>C	uc002fgp.2	+	10	1261	c.1189G>C	c.(1189-1191)GTG>CTG	p.V397L	CMIP_uc002fgq.1_Missense_Mutation_p.V303L|CMIP_uc010vnq.1_Missense_Mutation_p.V210L|CMIP_uc002fgr.1_Missense_Mutation_p.V244L	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	363						cytoplasm|nucleus					0						GTCGGTGGTCGTGGCCTCCAG	0.662													6	7					0	0	0	0	C	81712034	C	C	81712034	3	2	234	1	0	0	0	0	1	0	0	0	3593	1145	40	3	1249	3	CMIP	16	81712034	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	4358255	81712034	8642719	253	42465											
ZC3H18	124245	broad.mit.edu	37	chr16	88688786	88688786	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctcgtcagcctctgcctctAattcctccaggtaaggaggg	7	10	10	14	1	3	0	1	0	2	0	6	1	5	1	5	3	2	1	5	3	2	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:88688786A>T	uc002fky.2	+	9	1857	c.1657A>T	c.(1657-1659)AAT>TAT	p.N553Y	ZC3H18_uc010voz.1_Missense_Mutation_p.N577Y|ZC3H18_uc010chw.2_RNA	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	553	Ser-rich.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CTCTGCCTCTAATTCCTCCAG	0.622													4	21					0	0	0	0	T	88688786	T	T	88688786	3	4	234	1	0	0	0	0	1	0	0	0	17635	362	13	5	1687	5	ZC3H18	16	88688786	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	6976752	88688786	1665967	254	42466											
GALNS	2588	broad.mit.edu	37	chr16	88884501	88884501	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgaccgaggtgatcctgcTgagggcctcctggtactcgg	6	8	15	12	3	0	2	0	2	0	0	3	5	2	2	4	4	2	2	4	4	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr16:88884501T>A	uc002fly.3	-	13	1485	c.1396A>T	c.(1396-1398)AGC>TGC	p.S466C	GALNS_uc002flx.2_RNA|GALNS_uc010cid.2_Missense_Mutation_p.S472C|GALNS_uc002flz.3_Missense_Mutation_p.S149C	NM_000512	NP_000503	P34059	GALNS_HUMAN	galactosamine (N-acetyl)-6-sulfate sulfatase	466						lysosome	metal ion binding|N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity			large_intestine(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	GTGATCCTGCTGAGGGCCTCC	0.667													3	14					0	0	0	0	A	88884501	A	A	88884501	3	1	234	1	0	0	0	0	1	0	0	0	6241	1580	55	5	180	5	GALNS	16	88884501	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	195715	88884501	1470252	255	42467											
TP53	7157	broad.mit.edu	37	chr17	7578413	7578413	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggtgggggcagcgcctcaCaacctccgtcatgtgctgtg	6	9	14	12	2	2	0	2	0	0	0	3	0	3	0	3	3	3	2	3	3	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:7578413C>T	uc002gim.2	-	5	711	c.517G>A	c.(517-519)GTG>ATG	p.V173M	TP53_uc002gig.1_Missense_Mutation_p.V173M|TP53_uc002gih.2_Missense_Mutation_p.V173M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V41M|TP53_uc010cng.1_Missense_Mutation_p.V41M|TP53_uc002gii.1_Missense_Mutation_p.V41M|TP53_uc010cnh.1_Missense_Mutation_p.V173M|TP53_uc010cni.1_Missense_Mutation_p.V173M|TP53_uc002gij.2_Missense_Mutation_p.V173M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V80M|TP53_uc002gio.2_Missense_Mutation_p.V41M|TP53_uc010vug.1_Missense_Mutation_p.V134M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(54)|p.V173M(40)|p.V173A(8)|p.V173V(8)|p.0?(7)|p.V173G(6)|p.V173fs*1(4)|p.V80L(2)|p.V173fs*59(2)|p.V41L(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.V173E(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.V80M(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.V41M(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	51					0	0	0	0	T	7578413	T	T	7578413	3	4	234	1	0	0	0	0	1	0	0	0	16448	478	17	4	781	4	TP53	17	7578413	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08		7578413	73616797	256	42468											
DHRS7C	201140	broad.mit.edu	37	chr17	9676237	9676237	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctgcgtgcttggaggcagCgtctgcgagacaaaccatcc	8	7	14	12	3	1	1	0	0	1	1	2	3	2	2	2	3	5	3	2	3	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:9676237C>A	uc010vvb.1	-	5	577	c.577G>T	c.(577-579)GCT>TCT	p.A193S	DHRS7C_uc010cof.2_Missense_Mutation_p.A192S	NM_001105571	NP_001099041	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	193						extracellular region	binding|oxidoreductase activity				0						TTGGAGGCAGCGTCTGCGAGA	0.617													7	23					2.0095e-06	4.09758e-06	1	0	A	9676237	A	A	9676237	3	1	234	1	0	0	0	0	1	0	0	0	4519	768	27	3	369	3	DHRS7C	17	9676237	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	2097824	9676237	71518973	257	42469											
RNF135	84282	broad.mit.edu	37	chr17	29326072	29326072	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttgaggagggaaagcttGccttctattcagtggacaat	11	11	11	8	0	2	1	1	1	1	0	2	4	2	4	2	3	2	1	2	3	3	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:29326072G>T	uc002hfz.2	+	5	1298	c.1162G>T	c.(1162-1164)GCC>TCC	p.A388S	RNF135_uc002hga.2_3'UTR|RNF135_uc010csm.2_3'UTR|RNF135_uc002hgb.2_3'UTR	NM_032322	NP_115698	Q8IUD6	RN135_HUMAN	ring finger protein 135 isoform 1	388	B30.2/SPRY.				innate immune response|negative regulation of type I interferon production|positive regulation of interferon-beta production|regulation of innate immune response	cytosol	protein binding|ribonucleoprotein binding|ubiquitin-protein ligase activity|zinc ion binding	p.?(1)		skin(2)	2		all_cancers(10;8.65e-08)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Myeloproliferative disorder(56;0.0255)				GGGAAAGCTTGCCTTCTATTC	0.527													7	96					2.0095e-06	4.09758e-06	1	0	T	29326072	T	T	29326072	3	4	234	1	0	0	0	0	1	0	0	0	13505	1319	46	4	1249	4	RNF135	17	29326072	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	19649835	29326072	51869138	258	42470											
NF1	4763	broad.mit.edu	37	chr17	29553550	29553550	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttctgtggaaccctgacaCtgaagctgttctggttgcca	7	13	11	10	0	2	2	0	2	2	0	2	3	2	3	2	2	3	4	2	2	2	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	f50dc054-f0b0-4b11-be76-09ae612abc8e	g.chr17:29553550C>G	uc002hgg.2	+	18	2432	c.2099C>G	c.(2098-2100)ACT>AGT	p.T700S	NF1_uc002hgh.2_Missense_Mutation_p.T700S|NF1_uc010csn.1_Missense_Mutation_p.T560S|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	700					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AACCCTGACACTGAAGCTGTT	0.552			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			3	107					0	0	0	0	G	29553550	G	G	29553550	3	3	234	1	0	0	0	0	1	0	0	0	10410	565	20	4	2230	4	NF1	17	29553550	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	227478	29553550	51641660	259	42471											
SRCIN1	80725	broad.mit.edu	37	chr17	36720486	36720486	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgactcggcggaggcgtaggAcagctttgccgcctggtctg	5	8	16	12	5	1	0	0	0	1	0	2	3	1	2	2	5	2	2	2	5	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:36720486A>G	uc002hqd.2	-	4	634	c.409T>C	c.(409-411)TCC>CCC	p.S137P	SRCIN1_uc002hqf.1_5'Flank|SRCIN1_uc002hqe.2_5'UTR|SRCIN1_uc002hqh.1_Missense_Mutation_p.S197P	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						GAGGCGTAGGACAGCTTTGCC	0.687													3	5					0	0	0	0	G	36720486	G	G	36720486	3	3	234	1	0	0	0	0	1	0	0	0	15202	275	10	5	3206	5	SRCIN1	17	36720486	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	7166936	36720486	44474724	260	42472											
ERBB2	2064	broad.mit.edu	37	chr17	37884229	37884229	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caccagagcggggggctccaCccagcaccttcaaagggaca	11	3	12	15	1	1	1	1	0	0	1	2	2	2	2	4	4	2	2	4	4	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:37884229C>T	uc002hso.2	+	27	3938	c.3700C>T	c.(3700-3702)CCC>TCC	p.P1234S	ERBB2_uc002hsm.2_Missense_Mutation_p.P1204S|ERBB2_uc010cwa.2_Missense_Mutation_p.P1219S|ERBB2_uc002hsp.2_Missense_Mutation_p.P1037S|ERBB2_uc010cwb.2_3'UTR|ERBB2_uc010wek.1_Missense_Mutation_p.P958S	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	1234	Cytoplasmic (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GGGGGCTCCACCCAGCACCTT	0.632		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			12	68					0	0	0	0	T	37884229	T	T	37884229	3	4	234	1	0	0	0	0	1	0	0	0	5230	507	18	4	3806	4	ERBB2	17	37884229	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1163743	37884229	43310981	261	42473											
RARA	5914	broad.mit.edu	37	chr17	38508182	38508184	+	In_Frame_Del	DEL	AAG	-	-																															ctgtgagaaacgaccgaaacAagaagaagaaggaggtgccc																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:38508182_38508184delAAG	uc002huk.1	+	5	945_947	c.490_492delAAG	c.(490-492)AAGdel	p.K167del	RARA_uc002hul.3_In_Frame_Del_p.K167del|RARA_uc010wfe.1_In_Frame_Del_p.K70del|RARA_uc002hun.1_In_Frame_Del_p.K162del	NM_000964	NP_000955	P10276	RARA_HUMAN	retinoic acid receptor, alpha isoform 1	167	Hinge.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	CGACCGAAACAAGAAGAAGAAGG	0.616			T	PML|ZNF145|TIF1|NUMA1|NPM1	APL								---	---	---								-	38508184	-	-	38508182	7	5	234	1	0	1	0	1	0	0	0	0	13117	131	5	0	671	0	RARA	17	38508182	In_Frame_Del	DEL	AAG	TCGA-CV-7242-01A-11D-2012-08	623953	38508182	42687028	262	42474											
WNK4	65266	broad.mit.edu	37	chr17	40933194	40933194	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaggaagaaaaggaggacAtggagacccaggctgtggca	15	3	16	7	0	0	2	0	0	0	2	0	6	0	5	1	6	1	3	1	6	3	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:40933194A>G	uc002ibj.2	+	1	499	c.478A>G	c.(478-480)ATG>GTG	p.M160V	WNK4_uc010wgx.1_5'UTR|WNK4_uc002ibk.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	160					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		AAAGGAGGACATGGAGACCCA	0.627													19	49					0	0	0	0	G	40933194	G	G	40933194	3	3	234	1	0	0	0	0	1	0	0	0	17448	217	8	5	480	5	WNK4	17	40933194	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	2425012	40933194	40262016	263	42475											
IMP5	162540	broad.mit.edu	37	chr17	43922897	43922897	+	Frame_Shift_Del	DEL	G	-	-																															gctactgggccggcctgaccGaagccaaccggctacagcgg																								rs929223		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:43922897delG	uc010wka.1	+	1	625	c.625delG	c.(625-627)GAAfs	p.E209fs	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	209	Cytoplasmic (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		CGGCCTGACCGAAGCCAACCG	0.647													---	---	---								-	43922897	-	-	43922897	7	5	234	1	0	1	0	1	0	0	0	0	7760	1059	37	0	627	0	IMP5	17	43922897	Frame_Shift_Del	DEL	G	TCGA-CV-7242-01A-11D-2012-08	2989703	43922897	37272313	264	42476											
MRPL10	124995	broad.mit.edu	37	chr17	45901757	45901757	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctccccctgcaccaggggCaggctggggagcttggagta	7	6	16	12	0	0	0	0	0	0	0	1	2	1	2	3	6	3	6	3	6	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:45901757C>T	uc002ilz.2	-	5	626	c.600G>A	c.(598-600)CTG>CTA	p.L200L	OSBPL7_uc002ilx.1_5'Flank|MRPL10_uc010wky.1_Silent_p.L161L|MRPL10_uc002ily.2_Silent_p.L210L	NM_145255	NP_660298	Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10 precursor	200					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			ovary(1)	1						GCACCAGGGGCAGGCTGGGGA	0.617													21	41					0	0	0	0	T	45901757	T	T	45901757	2	4	234	1	0	0	0	0	0	0	0	1	9828	697	25	4		4	MRPL10	17	45901757	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1978860	45901757	35293453	265	42477											
COL1A1	1277	broad.mit.edu	37	chr17	48268775	48268775	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taggccctggaagaccagctGcaccacgttcaccaggcatt	10	7	10	14	1	1	1	1	0	0	1	1	2	1	2	4	3	2	4	4	3	2	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:48268775G>A	uc002iqm.2	-	32	2330	c.2204C>T	c.(2203-2205)GCA>GTA	p.A735V		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	735	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	AAGACCAGCTGCACCACGTTC	0.597			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						25	67					0	0	0	0	A	48268775	A	A	48268775	3	1	234	1	0	0	0	0	1	0	0	0	3692	1319	46	4	2270	4	COL1A1	17	48268775	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2367018	48268775	32926435	266	42478											
KIF2B	84643	broad.mit.edu	37	chr17	51901021	51901021	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atctcagtcctggagcccccGcaagaacatcgcatctgcgt	9	8	9	15	3	2	1	1	0	2	1	5	2	3	2	3	1	3	2	3	1	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:51901021G>C	uc002iua.2	+	1	783	c.627G>C	c.(625-627)CCG>CCC	p.P209P	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	209					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TGGAGCCCCCGCAAGAACATC	0.537													10	58					0	0	0	0	C	51901021	C	C	51901021	2	2	234	1	0	0	0	0	0	0	0	1	8337	1074	38	3		3	KIF2B	17	51901021	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	3632246	51901021	29294189	267	42479											
ABCA10	10349	broad.mit.edu	37	chr17	67218001	67218001	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagccagtactttgccaagtAacaaaaaatttcaccatgca	16	10	5	10	0	1	0	1	0	0	0	1	0	1	0	3	0	5	3	3	0	7	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:67218001A>G	uc010dfa.1	-	6	1114	c.235T>C	c.(235-237)TAC>CAC	p.Y79H	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfc.1_Intron	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	79					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TTTGCCAAGTAACAAAAAATT	0.338													7	14					0	0	0	0	G	67218001	G	G	67218001	3	3	234	1	0	0	0	0	1	0	0	0	29	362	13	5	4536	5	ABCA10	17	67218001	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	15316980	67218001	13977209	268	42480											
CCDC40	55036	broad.mit.edu	37	chr17	78011950	78011950	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggaagatggatcggcttctGagggagagaaggaagggaat	13	6	18	4	2	1	3	0	1	1	2	2	9	1	8	0	6	0	1	0	6	4	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:78011950G>C	uc010dht.2	+	2	85	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	TBC1D16_uc002jxj.2_5'Flank|CCDC40_uc010wub.1_Missense_Mutation_p.E20Q	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	20					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			ATCGGCTTCTGAGGGAGAGAA	0.418													5	35					0	0	0	0	C	78011950	C	C	78011950	3	2	234	1	0	0	0	0	1	0	0	0	2825	1291	45	2	64	2	CCDC40	17	78011950	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	10793949	78011950	3183260	269	42481											
NPLOC4	55666	broad.mit.edu	37	chr17	79564324	79564324	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtatcttctgagacgaggtCtgtaaatatccagccaacct	11	11	9	10	1	3	1	0	1	3	1	4	3	4	1	3	2	2	2	3	2	5	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:79564324C>A	uc002kat.3	-	10	1122	c.940G>T	c.(940-942)GAC>TAC	p.D314Y	NPLOC4_uc002kau.3_Missense_Mutation_p.D314Y|NPLOC4_uc010wur.1_Missense_Mutation_p.D153Y	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	314					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GAGACGAGGTCTGTAAATATC	0.388													16	74					3.52763e-06	7.13344e-06	1	0	A	79564324	A	A	79564324	3	1	234	1	0	0	0	0	1	0	0	0	10640	913	32	2	918	2	NPLOC4	17	79564324	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1552374	79564324	1630886	270	42482											
NPLOC4	55666	broad.mit.edu	37	chr17	79589283	79589283	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccgagaagccattattttGgaagccaaactcctttgcaa	14	10	7	10	1	0	1	0	0	0	1	1	3	1	2	4	1	5	1	4	1	6	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr17:79589283G>A	uc002kat.3	-	3	300	c.118C>T	c.(118-120)CAA>TAA	p.Q40*	NPLOC4_uc002kau.3_Nonsense_Mutation_p.Q40*|NPLOC4_uc010wur.1_5'UTR	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	40					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CCATTATTTTGGAAGCCAAAC	0.388													9	77					0	0	0	0	A	79589283	A	A	79589283	4	1	234	1	0	0	0	0	0	1	0	0	10640	1357	47	4	1768	4	NPLOC4	17	79589283	Nonsense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	24959	79589283	1605927	271	42483											
LPIN2	9663	broad.mit.edu	37	chr18	2937737	2937737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagctgccggtttggattctGagggcgcctccgctaaggct	5	11	14	11	3	1	1	0	1	1	0	2	2	2	2	3	4	2	4	3	4	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr18:2937737G>A	uc002klo.2	-	7	1360	c.1121C>T	c.(1120-1122)TCA>TTA	p.S374L		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	374					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		TTTGGATTCTGAGGGCGCCTC	0.463													20	74					0	0	0	0	A	2937737	A	A	2937737	3	1	234	1	0	0	0	0	1	0	0	0	8969	1294	45	2	1625	2	LPIN2	18	2937737	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08		2937737	75139511	272	42484											
TMEM200C	645369	broad.mit.edu	37	chr18	5890361	5890361	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagctctgctccgcacccaGaacgggggcggccacagcag	8	3	14	16	4	1	1	0	0	1	1	2	2	2	1	3	3	4	4	3	3	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr18:5890361G>T	uc002kmx.1	-	1	1743	c.1702C>A	c.(1702-1704)CTG>ATG	p.L568M		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	568						integral to membrane					0						TCCGCACCCAGAACGGGGGCG	0.652													14	47					7.93312e-07	1.64056e-06	1	0	T	5890361	T	T	5890361	3	4	234	1	0	0	0	0	1	0	0	0	16191	933	33	2	167	2	TMEM200C	18	5890361	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2952624	5890361	72186887	273	42485											
OSBPL1A	114876	broad.mit.edu	37	chr18	21751402	21751402	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaatgtagccttcaactttGtgtaattccttaccaaaaag	13	14	6	8	0	1	1	1	1	0	0	2	1	2	1	3	0	3	2	3	0	7	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr18:21751402G>C	uc002kve.2	-	23	2436	c.2262C>G	c.(2260-2262)CAC>CAG	p.H754Q	OSBPL1A_uc002kvd.2_Missense_Mutation_p.H241Q|OSBPL1A_uc010xbc.1_Missense_Mutation_p.H372Q	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	754					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					CTTCAACTTTGTGTAATTCCT	0.294													31	71					0	0	0	0	C	21751402	C	C	21751402	3	2	234	1	0	0	0	0	1	0	0	0	11331	1368	48	4	614	4	OSBPL1A	18	21751402	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	15861041	21751402	56325846	274	42486											
ASXL3	80816	broad.mit.edu	37	chr18	31226289	31226289	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggtacagatatggccgaGgcaaatgcccatggagaaga	14	6	14	7	1	0	3	0	0	0	3	0	6	0	3	2	4	2	2	2	4	4	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr18:31226289G>A	uc010dmg.1	+	4	382	c.327G>A	c.(325-327)GAG>GAA	p.E109E	ASXL3_uc002kxq.2_5'UTR	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ATATGGCCGAGGCAAATGCCC	0.383													17	45					0	0	0	0	A	31226289	A	A	31226289	2	1	234	1	0	0	0	0	0	0	0	1	1070	991	35	4		4	ASXL3	18	31226289	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	9474887	31226289	46850959	275	42487											
MAPK4	5596	broad.mit.edu	37	chr18	48190452	48190452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtcggccgtggacagccggGcctgccggaaggtcgctgtg	4	7	18	12	5	0	0	0	0	0	0	2	2	0	2	4	5	2	1	4	5	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr18:48190452G>A	uc002lev.2	+	2	1124	c.124G>A	c.(124-126)GCC>ACC	p.A42T	MAPK4_uc010xdm.1_Intron|MAPK4_uc010doz.2_Missense_Mutation_p.A42T	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	42	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GGACAGCCGGGCCTGCCGGAA	0.612													14	48					0	0	0	0	A	48190452	A	A	48190452	3	1	234	1	0	0	0	0	1	0	0	0	9333	1203	42	4	126	4	MAPK4	18	48190452	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	16964163	48190452	29886796	276	42488											
DOK6	220164	broad.mit.edu	37	chr18	67406203	67406203	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatctctattctcacagaaTgtgtgacacaggagaaggac	13	10	9	9	0	2	3	1	1	2	2	4	5	2	4	0	2	0	0	0	2	4	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr18:67406203T>C	uc002lkl.2	+	6	792	c.602T>C	c.(601-603)ATG>ACG	p.M201T		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	201	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TCTCACAGAATGTGTGACACA	0.453													30	77					0	0	0	0	C	67406203	C	C	67406203	3	2	234	1	0	0	0	0	1	0	0	0	4723	1464	51	5	624	5	DOK6	18	67406203	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	19215751	67406203	10671045	277	42489											
ABCA7	10347	broad.mit.edu	37	chr19	1058907	1058912	+	In_Frame_Del	DEL	GGGGAT	-	-																															tggtccaaggagccacccagGgggatgtgttggtgctgagg																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:1058907_1058912delGGGGAT	uc002lqw.3	+	39	5599_5604	c.5368_5373delGGGGAT	c.(5368-5373)GGGGATdel	p.GD1790del	ABCA7_uc002lqy.2_In_Frame_Del_p.GD243del|ABCA7_uc010dsc.2_RNA	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1790_1791					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCCACCCAGGGGGATGTGTTGGTGC	0.626													---	---	---								-	1058912	-	-	1058907	7	5	234	1	0	1	0	1	0	0	0	0	37	1232	43	0	5518	0	ABCA7	19	1058907	In_Frame_Del	DEL	GGGGAT	TCGA-CV-7242-01A-11D-2012-08		1058907	58070076	278	42490											
C19orf35	374872	broad.mit.edu	37	chr19	2276353	2276353	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcggctgccagcgccactgCgcctctccagggcgccccgg	3	5	13	20	5	1	0	0	0	1	0	3	0	1	0	6	3	3	1	6	3	0	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:2276353C>T	uc002lvn.2	-	4	848	c.748G>A	c.(748-750)GCA>ACA	p.A250T	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	250										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCGCCACTGCGCCTCTCCAG	0.711													7	16					0	0	0	0	T	2276353	T	T	2276353	3	4	234	1	0	0	0	0	1	0	0	0	1929	768	27	1	677	1	C19orf35	19	2276353	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1217446	2276353	56852630	279	42491											
MRPL54	116541	broad.mit.edu	37	chr19	3762721	3762721	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcgaccaaacgccttttcgGggctacccggacgtgggccg	6	6	15	14	6	0	0	0	0	0	0	1	2	0	1	4	5	2	1	4	5	2	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:3762721G>T	uc002lyq.3	+	1	57	c.23G>T	c.(22-24)GGG>GTG	p.G8V	APBA3_uc002lyp.1_5'Flank	NM_172251	NP_758455	Q6P161	RM54_HUMAN	mitochondrial ribosomal protein L54 precursor	8						mitochondrion|ribosome					0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCTTTTCGGGGCTACCCGG	0.627													22	92					4.26978e-12	9.92655e-12	1	0	T	3762721	T	T	3762721	3	4	234	1	0	0	0	0	1	0	0	0	9871	1232	43	4	25	4	MRPL54	19	3762721	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	1486368	3762721	55366262	280	42492											
MATK	4145	broad.mit.edu	37	chr19	3784203	3784203	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcagcccctcctgtccaCtggtgtggtgcttgacgcgg	4	9	13	15	2	0	1	0	1	0	0	2	1	2	1	5	3	3	2	5	3	0	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:3784203C>A	uc002lyt.2	-	5	681	c.281G>T	c.(280-282)AGT>ATT	p.S94I	MATK_uc002lyv.2_Missense_Mutation_p.S95I|MATK_uc002lyu.2_Missense_Mutation_p.S53I|MATK_uc010dtq.2_Missense_Mutation_p.S94I	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	94	SH3.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCTGTCCACTGGTGTGGTG	0.692													23	57					4.26978e-12	9.92655e-12	1	0	A	3784203	A	A	3784203	3	1	234	1	0	0	0	0	1	0	0	0	9385	565	20	4	1282	4	MATK	19	3784203	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	21482	3784203	55344780	281	42493											
PTPRS	5802	broad.mit.edu	37	chr19	5222178	5222178	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtcagggaactcccagcTgagcagaactgatgtcttca	10	10	11	10	0	3	3	2	2	1	1	4	4	4	4	1	1	4	3	1	1	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:5222178T>A	uc002mbv.2	-	19	3391	c.3157A>T	c.(3157-3159)AGC>TGC	p.S1053C	PTPRS_uc002mbu.1_Missense_Mutation_p.S622C|PTPRS_uc010xin.1_Missense_Mutation_p.S622C|PTPRS_uc002mbw.2_Missense_Mutation_p.S1031C|PTPRS_uc002mbx.2_Missense_Mutation_p.S626C|PTPRS_uc002mby.2_Missense_Mutation_p.S622C	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1053	Extracellular (Potential).|Fibronectin type-III 8.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		AACTCCCAGCTGAGCAGAACT	0.507													26	71					0	0	0	0	A	5222178	A	A	5222178	3	1	234	1	0	0	0	0	1	0	0	0	12876	1580	55	5	2769	5	PTPRS	19	5222178	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	1437975	5222178	53906805	282	42494											
DUS3L	56931	broad.mit.edu	37	chr19	5787365	5787365	+	Frame_Shift_Del	DEL	C	-	-																															agcgattcatgagggcacagCccccaccctggaagagacag																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:5787365delC	uc002mdc.2	-	7	1317	c.1220delG	c.(1219-1221)GGCfs	p.G407fs	PRR22_uc002mdb.1_5'Flank|PRR22_uc010xiv.1_5'Flank|DUS3L_uc002mdd.2_Frame_Shift_Del_p.G165fs|DUS3L_uc010duk.2_Frame_Shift_Del_p.G72fs	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	407					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0						GAGGGCACAGCCCCCACCCTG	0.662													---	---	---								-	5787365	-	-	5787365	7	5	234	1	0	1	0	1	0	0	0	0	4829	739	26	0	760	0	DUS3L	19	5787365	Frame_Shift_Del	DEL	C	TCGA-CV-7242-01A-11D-2012-08	565187	5787365	53341618	283	42495											
ARHGEF18	23370	broad.mit.edu	37	chr19	7518437	7518437	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggacgccaaggtcagtgAgtgtgagaagggccagcgcc	10	5	17	9	2	1	2	1	2	0	1	1	4	1	3	3	3	1	0	3	3	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:7518437A>T	uc002mgi.2	+	7	1629	c.1376A>T	c.(1375-1377)GAG>GTG	p.E459V	ARHGEF18_uc010xjm.1_Missense_Mutation_p.E301V|ARHGEF18_uc002mgh.2_Missense_Mutation_p.E301V|ARHGEF18_uc002mgj.1_Missense_Mutation_p.E102V	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	459					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				AAGGTCAGTGAGTGTGAGAAG	0.542													27	76					0	0	0	0	T	7518437	T	T	7518437	3	4	234	1	0	0	0	0	1	0	0	0	901	304	11	5	1402	5	ARHGEF18	19	7518437	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	1731072	7518437	51610546	284	42496											
CARM1	10498	broad.mit.edu	37	chr19	11032327	11032328	+	Missense_Mutation	DNP	CG	TT	TT																															gggcagtggtggtggcagcaCgagtgcccactatgcagtca																								rs139191688	byFrequency	TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:11032327_11032328CG>TT	uc002mpz.2	+	16	1847_1848	c.1721_1722CG>TT	c.(1720-1722)ACG>ATT	p.T574I	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_Missense_Mutation_p.T334I	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	574	Transactivation domain (By similarity).				cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						GGTGGCAGCACGAGTGCCCACT	0.673													19	62					0	0	0	0	TT	11032328	TT	TT	11032327	3	4	234	1	0	0	0	0	1	0	0	0	2667	536	19	1	1783	1	CARM1	19	11032327	Missense_Mutation	DNP	CG	TCGA-CV-7242-01A-11D-2012-08	3513890	11032327	48096656	285	42497											
ZNF44	51710	broad.mit.edu	37	chr19	12384496	12384496	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttataaggtccatctccacCttttactaccatatgtcttc	9	17	3	12	0	2	0	0	0	2	0	5	0	3	0	4	1	2	0	4	1	5	8			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:12384496C>A	uc010xmj.1	-	5	923	c.718G>T	c.(718-720)GGT>TGT	p.G240C	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.G192C	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		CCATCTCCACCTTTTACTACC	0.403													28	60					4.87955e-14	1.16028e-13	1	0	A	12384496	A	A	12384496	3	1	234	1	0	0	0	0	1	0	0	0	17979	681	24	4	1277	4	ZNF44	19	12384496	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1352169	12384496	46744487	286	42498											
DNASE2	1777	broad.mit.edu	37	chr19	12991695	12991695	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtagagcaggaaggcgagCtgcgggcggataaacggagg	11	5	19	6	4	0	1	0	0	0	1	0	5	0	4	0	6	4	3	0	6	4	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:12991695C>G	uc002mvn.1	-	3	414	c.268_splice	c.e3-1	p.L90_splice	DNASE2_uc010xmr.1_Splice_Site_p.L90_splice	NM_001375	NP_001366	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal precursor						apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding				0						GGAAGGCGAGCTGCGGGCGGA	0.632								Direct_reversal_of_damage					14	72					0	0	0	0	G	12991695	G	G	12991695	5	3	234	1	0	0	0	0	0	0	1	0	4686	811	28	4	831	4	DNASE2	19	12991695	Splice_Site	SNP	C	TCGA-CV-7242-01A-11D-2012-08	607199	12991695	46137288	287	42499											
CYP4F3	4051	broad.mit.edu	37	chr19	15770178	15770178	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agggcggactttggctgcggGtggagcccctgagctgagtt	5	9	18	9	2	0	2	0	2	0	0	0	4	0	4	2	5	3	3	2	5	0	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:15770178G>C	uc002nbj.2	+	13	1596	c.1546G>C	c.(1546-1548)GTG>CTG	p.V516L	CYP4F3_uc010xok.1_Missense_Mutation_p.V516L|CYP4F3_uc010xol.1_Missense_Mutation_p.V516L|CYP4F3_uc010xom.1_Missense_Mutation_p.V367L|CYP4F3_uc002nbk.2_Missense_Mutation_p.V516L|CYP4F3_uc010xon.1_Missense_Mutation_p.V226L	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	516					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TTGGCTGCGGGTGGAGCCCCT	0.532													6	25					0	0	0	0	C	15770178	C	C	15770178	3	2	234	1	0	0	0	0	1	0	0	0	4207	1261	44	4	1592	4	CYP4F3	19	15770178	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2778483	15770178	43358805	288	42500											
MED26	9441	broad.mit.edu	37	chr19	16687968	16687968	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggtgtgcggtcgcacggCgttgacggggatcttgccac	4	9	17	11	5	1	1	0	1	1	0	2	2	1	2	1	5	2	3	1	5	0	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:16687968C>T	uc002nen.1	-	3	934	c.673G>A	c.(673-675)GCC>ACC	p.A225T	MED26_uc002nee.2_RNA	NM_004831	NP_004822	O95402	MED26_HUMAN	mediator complex subunit 26	225					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			ovary(2)	2						GGTCGCACGGCGTTGACGGGG	0.672													16	48					0	0	0	0	T	16687968	T	T	16687968	3	4	234	1	0	0	0	0	1	0	0	0	9497	768	27	1	1133	1	MED26	19	16687968	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	917790	16687968	42441015	289	42501											
CRLF1	9244	broad.mit.edu	37	chr19	18707506	18707506	+	Frame_Shift_Del	DEL	C	-	-																															ctttcttggagccatagatgCcaaaggggttgcagcgcact																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:18707506delC	uc010ebt.1	-	6	1144	c.950delG	c.(949-951)GGCfs	p.G317fs		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	317	Fibronectin type-III 2.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						GCCATAGATGCCAAAGGGGTT	0.642													---	---	---								-	18707506	-	-	18707506	7	5	234	1	0	1	0	1	0	0	0	0	3901	739	26	0	334	0	CRLF1	19	18707506	Frame_Shift_Del	DEL	C	TCGA-CV-7242-01A-11D-2012-08	2019538	18707506	40421477	290	42502											
ZNF253	56242	broad.mit.edu	37	chr19	20002921	20002922	+	Frame_Shift_Del	DEL	TG	-	-																															aaccctacaaatgtgaagaaTgtggcaaagcctttaagcac																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:20002921_20002922delTG	uc002noj.2	+	4	957_958	c.865_866delTG	c.(865-867)TGTfs	p.C289fs	ZNF253_uc002nok.2_Frame_Shift_Del_p.C213fs|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	289	C2H2-type 5.			Missing (in Ref. 1; AAC26844).|Missing (in Ref. 2; BAC11185).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGTGAAGAATGTGGCAAAGCC	0.411													---	---	---								-	20002922	-	-	20002921	7	5	234	1	0	1	0	1	0	0	0	0	17864	1464	51	0	879	0	ZNF253	19	20002921	Frame_Shift_Del	DEL	TG	TCGA-CV-7242-01A-11D-2012-08	1295415	20002921	39126062	291	42503											
SLC7A9	11136	broad.mit.edu	37	chr19	33353084	33353084	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggctcccacagacagcTgggcgccctcgaaagaatta	11	7	11	12	2	0	3	0	1	0	2	2	4	1	3	2	2	1	2	2	2	3	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:33353084T>C	uc002ntv.3	-	6	761	c.644A>G	c.(643-645)CAG>CGG	p.Q215R	SLC7A9_uc002ntt.3_Intron|SLC7A9_uc002ntu.3_Missense_Mutation_p.Q215R|SLC7A9_uc002ntw.3_Intron	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	215	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	CACAGACAGCTGGGCGCCCTC	0.537													16	71					0	0	0	0	C	33353084	C	C	33353084	3	2	234	1	0	0	0	0	1	0	0	0	14769	1580	55	5	851	5	SLC7A9	19	33353084	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	13350163	33353084	25775899	292	42504											
ZNF792	126375	broad.mit.edu	37	chr19	35449469	35449469	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggctggcaatgtggctgaaGaatttcccacattcgttaca	11	11	10	9	1	0	2	0	1	0	1	2	2	1	2	1	3	1	4	1	3	4	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:35449469G>C	uc002nxh.1	-	4	1677	c.1290C>G	c.(1288-1290)TTC>TTG	p.F430L		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	430	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGTGGCTGAAGAATTTCCCAC	0.483													29	71					0	0	0	0	C	35449469	C	C	35449469	3	2	234	1	0	0	0	0	1	0	0	0	18231	933	33	2	612	2	ZNF792	19	35449469	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2096385	35449469	23679514	293	42505											
HAUS5	23354	broad.mit.edu	37	chr19	36111009	36111009	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agcgctgagccacaagctggGgctgcctccagggaaggtga	9	5	16	11	1	0	2	0	2	0	0	1	3	1	3	3	4	4	3	3	4	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:36111009G>T	uc002oam.1	+	16	1553	c.1502G>T	c.(1501-1503)GGG>GTG	p.G501V		NM_015302	NP_056117	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	501					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle					0						CACAAGCTGGGGCTGCCTCCA	0.677													42	83					1.62957e-23	4.29454e-23	1	0	T	36111009	T	T	36111009	3	4	234	1	0	0	0	0	1	0	0	0	7008	1232	43	4	1564	4	HAUS5	19	36111009	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	661540	36111009	23017974	294	42506											
CLIP3	25999	broad.mit.edu	37	chr19	36515346	36515346	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccaggcgcaagcccagtgcGctaagcatgagattgcctgg	9	6	13	13	2	0	1	0	1	0	1	0	2	0	1	3	2	4	3	3	2	2	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:36515346G>T	uc010eeq.1	-	6	1152	c.870C>A	c.(868-870)AGC>AGA	p.S290R	uc002ocy.2_Intron|CLIP3_uc002ocz.1_Missense_Mutation_p.S290R	NM_015526	NP_056341	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	290					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AGCCCAGTGCGCTAAGCATGA	0.622													22	47					3.8784e-16	9.63005e-16	1	0	T	36515346	T	T	36515346	3	4	234	1	0	0	0	0	1	0	0	0	3549	1078	38	3	805	3	CLIP3	19	36515346	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	404337	36515346	22613637	295	42507											
HKR1	284459	broad.mit.edu	37	chr19	37838218	37838218	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ataaccatctggtctcactgGgtaagaatggcctcccttgg	9	11	10	11	0	2	1	1	0	2	1	4	1	3	1	3	4	1	1	3	4	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:37838218G>C	uc002ogb.2	+	4	486	c.217G>C	c.(217-219)GAA>CAA	p.E73Q	HKR1_uc002ofx.2_5'UTR|HKR1_uc002ofy.2_Intron|HKR1_uc002ofz.2_Missense_Mutation_p.E54Q|HKR1_uc002oga.2_Missense_Mutation_p.E54Q|HKR1_uc010xto.1_Missense_Mutation_p.E54Q|HKR1_uc002ogc.2_Missense_Mutation_p.E54Q|HKR1_uc010xtp.1_Missense_Mutation_p.E12Q|HKR1_uc002ogd.2_Missense_Mutation_p.E12Q	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	73	KRAB.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGTCTCACTGGGTAAGAATGG	0.522													21	40					0	0	0	0	C	37838218	C	C	37838218	3	2	234	1	0	0	0	0	1	0	0	0	7233	1246	43	4	223	4	HKR1	19	37838218	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	1322872	37838218	21290765	296	42508											
PLEKHG2	64857	broad.mit.edu	37	chr19	39913657	39913658	+	Missense_Mutation	DNP	CG	TT	TT																															gtgaaattcccgaaggttctCgccttcctagtctctctgac																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:39913657_39913658CG>TT	uc010xuz.1	+	18	2288_2289	c.1963_1964CG>TT	c.(1963-1965)CGC>TTC	p.R655F	PLEKHG2_uc010xuy.1_Missense_Mutation_p.R596F|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.R433F	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	655					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGAAGGTTCTCGCCTTCCTAGT	0.53													46	125					0	0	0	0	TT	39913658	TT	TT	39913657	3	4	234	1	0	0	0	0	1	0	0	0	12124	884	31	1	2029	1	PLEKHG2	19	39913657	Missense_Mutation	DNP	CG	TCGA-CV-7242-01A-11D-2012-08	2075439	39913657	19215326	297	42509											
CEACAM3	1084	broad.mit.edu	37	chr19	42312886	42312886	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttcctgtgggggccgtcGccggcatcgtgaccggggtc	2	8	17	14	5	0	1	0	1	0	0	4	1	1	1	5	5	0	1	5	5	0	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:42312886G>A	uc002orn.1	+	3	536	c.460G>A	c.(460-462)GCC>ACC	p.A154T	CEACAM3_uc010eia.1_Missense_Mutation_p.A154T|CEACAM3_uc002oro.1_RNA	NM_001815	NP_001806	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion	154	Extracellular (Potential).					integral to membrane				skin(1)	1						GGGGGCCGTCGCCGGCATCGT	0.607													7	250					0	0	0	0	A	42312886	A	A	42312886	3	1	234	1	0	0	0	0	1	0	0	0	3208	1087	38	1	470	1	CEACAM3	19	42312886	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	2399229	42312886	16816097	298	42510											
PSG11	5680	broad.mit.edu	37	chr19	43519501	43519501	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagaggtgactgaagggaaaAttctggggaggtctggacca	13	7	16	5	0	2	3	0	2	2	1	2	6	2	6	1	6	0	0	1	6	4	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:43519501A>T	uc002ovm.1	-	4	838	c.731T>A	c.(730-732)ATT>AAT	p.I244N	PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG11_uc002ovn.1_Missense_Mutation_p.I250N|PSG11_uc002ovo.1_Missense_Mutation_p.I122N|PSG11_uc002ovp.1_Missense_Mutation_p.I122N	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	244	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TGAAGGGAAAATTCTGGGGAG	0.478													28	132					0	0	0	0	T	43519501	T	T	43519501	3	4	234	1	0	0	0	0	1	0	0	0	12716	101	4	5	284	5	PSG11	19	43519501	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	1206615	43519501	15609482	299	42511											
KLC3	147700	broad.mit.edu	37	chr19	45852823	45852823	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctatgaggcactgggcgggcCccatgaccccaacgtggcca	8	5	13	15	2	0	2	0	2	0	0	0	2	0	2	5	4	1	1	5	4	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:45852823C>A	uc002pbf.1	+	8	1221	c.1106C>A	c.(1105-1107)CCC>CAC	p.P369H	KLC3_uc010ejy.1_Missense_Mutation_p.P368H|KLC3_uc002pbg.1_Missense_Mutation_p.P383H	NM_177417	NP_803136	Q6P597	KLC3_HUMAN	kinesin light chain 3	369						cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CTGGGCGGGCCCCATGACCCC	0.647													13	33					4.7546e-09	1.02688e-08	1	0	A	45852823	A	A	45852823	3	1	234	1	0	0	0	0	1	0	0	0	8374	623	22	4	1132	4	KLC3	19	45852823	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	2333322	45852823	13276160	300	42512											
TBC1D17	79735	broad.mit.edu	37	chr19	50390975	50390975	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctctgtcccgcaccctcagGtgctgtggacagggctccct	4	9	11	17	1	2	0	1	0	1	0	4	1	4	1	4	3	1	3	4	3	0	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:50390975G>T	uc002pqo.2	+	15	1695	c.1543G>T	c.(1543-1545)GTG>TTG	p.V515L	TBC1D17_uc010ybg.1_Missense_Mutation_p.V482L|TBC1D17_uc002pqp.2_Missense_Mutation_p.V166L|TBC1D17_uc002pqr.2_Missense_Mutation_p.V166L|TBC1D17_uc002pqs.2_RNA|IL4I1_uc002pqv.1_3'UTR|IL4I1_uc010eno.1_3'UTR|IL4I1_uc002pqw.1_3'UTR	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	515	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		GCACCCTCAGGTGCTGTGGAC	0.682													8	23					0.000157383	0.000304747	1	0	T	50390975	T	T	50390975	3	4	234	1	0	0	0	0	1	0	0	0	15672	1275	44	4	1601	4	TBC1D17	19	50390975	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	4538152	50390975	8738008	301	42513											
SHANK1	50944	broad.mit.edu	37	chr19	51172432	51172432	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtgctgtagggaggctccgGtggggacgtggtgggtggcg	3	9	23	6	3	0	0	0	0	0	0	1	2	1	2	1	8	1	3	1	8	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:51172432G>T	uc002psx.1	-	22	2804	c.2785C>A	c.(2785-2787)CCG>ACG	p.P929T	SHANK1_uc002psw.1_Missense_Mutation_p.P313T	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	929					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GGAGGCTCCGGTGGGGACGTG	0.667											OREG0025642	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	10					3.59834e-05	7.138e-05	1	0	T	51172432	T	T	51172432	3	4	234	1	0	0	0	0	1	0	0	0	14329	1261	44	4	3708	4	SHANK1	19	51172432	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	781457	51172432	7956551	302	42514											
SIGLEC7	27036	broad.mit.edu	37	chr19	51650065	51650065	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggcggtcgggggagctggagCcacagccctggtcttcctct	4	8	16	13	2	2	0	0	0	2	0	4	2	3	2	3	6	3	1	3	6	0	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:51650065C>A	uc002pvv.1	+	5	1151	c.1082C>A	c.(1081-1083)GCC>GAC	p.A361D	SIGLEC7_uc002pvw.1_Missense_Mutation_p.A268D|SIGLEC7_uc010eoq.1_Intron|SIGLEC7_uc010eor.1_Intron	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	361	Helical; (Potential).				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		GGAGCTGGAGCCACAGCCCTG	0.577													24	85					4.4004e-07	9.17798e-07	1	0	A	51650065	A	A	51650065	3	1	234	1	0	0	0	0	1	0	0	0	14378	739	26	4	1100	4	SIGLEC7	19	51650065	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	477633	51650065	7478918	303	42515											
ZNF808	388558	broad.mit.edu	37	chr19	53058333	53058333	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcagtaacaggtcatccCttgtatgccatcgtagaatt	10	13	7	11	1	2	1	2	0	0	1	4	1	3	1	3	1	2	3	3	1	4	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:53058333C>A	uc010epq.1	+	5	2341	c.2164C>A	c.(2164-2166)CTT>ATT	p.L722I	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	722	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CAGGTCATCCCTTGTATGCCA	0.443													7	265					0.00307968	0.00574978	1	0	A	53058333	A	A	53058333	3	1	234	1	0	0	0	0	1	0	0	0	18240	681	24	4	2174	4	ZNF808	19	53058333	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1408268	53058333	6070650	304	42516											
NLRP12	91662	broad.mit.edu	37	chr19	54313274	54313275	+	Missense_Mutation	DNP	CG	TC	TC																															cctttcagaaaacgcgtactCggtcaacagcctggtcacgt																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:54313274_54313275CG>TC	uc002qch.3	-	3	1858_1859	c.1638_1639CG>GA	c.(1636-1641)ACCGAG>ACGAAG	p.E547K	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.E547K|NLRP12_uc002qcj.3_Missense_Mutation_p.E547K|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.E547K	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	547					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AACGCGTACTCGGTCAACAGCC	0.569													44	86					0	0	0	0	TC	54313275	TC	TC	54313274	3	4	234	1	0	0	0	0	1	0	0	0	10528	893	31	1	1674	1	NLRP12	19	54313274	Missense_Mutation	DNP	CG	TCGA-CV-7242-01A-11D-2012-08	1254941	54313274	4815709	305	42517											
CACNG6	59285	broad.mit.edu	37	chr19	54515287	54515287	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcagcccggagcctcccccGgccccacgcctcacctacga	6	4	9	22	4	2	0	2	0	0	0	3	2	3	1	8	2	3	0	8	2	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:54515287G>T	uc002qct.2	+	4	1217	c.627G>T	c.(625-627)CCG>CCT	p.P209P	CACNG6_uc002qcu.2_Silent_p.P163P|CACNG6_uc002qcv.2_Silent_p.P138P	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	209						voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		AGCCTCCCCCGGCCCCACGCC	0.692													15	60					3.41278e-10	7.66563e-10	1	0	T	54515287	T	T	54515287	2	4	234	1	0	0	0	0	0	0	0	1	2573	1103	39	3		3	CACNG6	19	54515287	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	202013	54515287	4613696	306	42518											
CNOT3	4849	broad.mit.edu	37	chr19	54646740	54646740	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggacaagcgcaaactccaagGtactagactgacttcctgct	12	8	9	12	1	0	2	0	1	0	1	2	3	2	3	2	2	4	3	2	2	5	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:54646740G>T	uc002qdj.1	+	2	336	c.25_splice	c.e2+1	p.G9_splice	CNOT3_uc010yel.1_Splice_Site_p.G9_splice|CNOT3_uc002qdi.2_Splice_Site|CNOT3_uc002qdk.1_Splice_Site_p.G9_splice|CNOT3_uc010ere.1_5'Flank	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					AAACTCCAAGGTACTAGACTG	0.537													20	81					1.96292e-10	4.46397e-10	1	0	T	54646740	T	T	54646740	5	4	234	1	0	0	0	0	0	0	1	0	3635	1275	44	4	28	4	CNOT3	19	54646740	Splice_Site	SNP	G	TCGA-CV-7242-01A-11D-2012-08	131453	54646740	4482243	307	42519											
PEG3	5178	broad.mit.edu	37	chr19	57328850	57328850	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaactgcgtgacacatcCttgatgaatttttccattat	10	16	7	8	1	0	3	0	3	0	0	2	4	2	4	2	1	2	0	2	1	3	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr19:57328850C>G	uc002qnu.2	-	7	1311	c.960G>C	c.(958-960)AAG>AAC	p.K320N	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.K291N|PEG3_uc002qnv.2_Missense_Mutation_p.K320N|PEG3_uc002qnw.2_Missense_Mutation_p.K196N|PEG3_uc002qnx.2_Missense_Mutation_p.K194N|PEG3_uc010etr.2_Missense_Mutation_p.K320N	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	320					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTGACACATCCTTGATGAATT	0.463													37	92					0	0	0	0	G	57328850	G	G	57328850	3	3	234	1	0	0	0	0	1	0	0	0	11774	680	24	4	3810	4	PEG3	19	57328850	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	2682110	57328850	1800133	308	42520											
SRXN1	140809	broad.mit.edu	37	chr20	629443	629443	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttggcggggatggtctctCgctgcagttgctggtaggcc	3	11	17	10	2	1	0	0	0	1	0	3	1	1	1	1	6	2	6	1	6	1	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:629443C>A	uc002wea.2	-	2	390	c.329G>T	c.(328-330)CGA>CTA	p.R110L	SRXN1_uc002web.2_RNA	NM_080725	NP_542763	Q9BYN0	SRXN1_HUMAN	sulfiredoxin 1 homolog	110					response to oxidative stress	cytosol	antioxidant activity|ATP binding|DNA binding|sulfiredoxin activity			ovary(1)	1						GATGGTCTCTCGCTGCAGTTG	0.607													27	77					2.44723e-14	5.89597e-14	1	0	A	629443	A	A	629443	3	1	234	1	0	0	0	0	1	0	0	0	15239	884	31	3	88	3	SRXN1	20	629443	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08		629443	62396077	309	42521											
SNPH	9751	broad.mit.edu	37	chr20	1285985	1285985	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgagccggacggacgcgCtggaagccagcagcctgctg	8	4	15	14	4	0	1	0	1	0	0	0	4	0	4	3	3	5	3	3	3	1	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:1285985C>A	uc002wes.2	+	6	1008	c.772C>A	c.(772-774)CTG>ATG	p.L258M	SNPH_uc002wet.2_Missense_Mutation_p.L302M	NM_014723	NP_055538	O15079	SNPH_HUMAN	syntaphilin	258					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			ovary(2)	2						GACGGACGCGCTGGAAGCCAG	0.682													23	49					1.85244e-09	4.08544e-09	1	0	A	1285985	A	A	1285985	3	1	234	1	0	0	0	0	1	0	0	0	14914	796	28	4	786	4	SNPH	20	1285985	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	656542	1285985	61739535	310	42522											
TGM3	7053	broad.mit.edu	37	chr20	2312716	2312716	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacccaacacgccatttgccGcgacgtcttcaatgggtttg	9	10	9	13	4	2	0	1	0	1	0	2	1	2	0	3	1	3	1	3	1	3	3			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:2312716G>A	uc002wfx.3	+	10	1499	c.1402G>A	c.(1402-1404)GCG>ACG	p.A468T		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	468		Cleavage; by CTSL.			cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	GCCATTTGCCGCGACGTCTTC	0.517													6	60					0	0	0	0	A	2312716	A	A	2312716	3	1	234	1	0	0	0	0	1	0	0	0	15897	1087	38	1	1440	1	TGM3	20	2312716	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	1026731	2312716	60712804	311	42523											
TGM3	7053	broad.mit.edu	37	chr20	2321165	2321165	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcaccaagcaactgctcgccGacttctcctgcaacaagttc	10	8	7	16	2	1	0	0	0	1	0	4	1	1	0	3	0	5	5	3	0	4	2	rs140423684		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:2321165G>C	uc002wfx.3	+	13	2117	c.2020G>C	c.(2020-2022)GAC>CAC	p.D674H		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	674				D -> G (in Ref. 2; BAF84040).	cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	ACTGCTCGCCGACTTCTCCTG	0.602													29	72					0	0	0	0	C	2321165	C	C	2321165	3	2	234	1	0	0	0	0	1	0	0	0	15897	1058	37	3	2070	3	TGM3	20	2321165	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	8449	2321165	60704355	312	42524											
IDH3B	3420	broad.mit.edu	37	chr20	2640691	2640691	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcaccgtctcaaagactgcGtattctgcactatagctctc	9	12	6	14	2	4	1	2	0	3	1	6	1	4	1	1	0	3	3	1	0	4	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:2640691G>A	uc002wgp.2	-	9	909	c.900C>T	c.(898-900)TAC>TAT	p.Y300Y	IDH3B_uc002wgq.2_Silent_p.Y300Y|IDH3B_uc002wgr.2_Silent_p.Y148Y	NM_006899	NP_008830	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3, beta subunit isoform	300					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	CAAAGACTGCGTATTCTGCAC	0.532													28	109					0	0	0	0	A	2640691	A	A	2640691	2	1	234	1	0	0	0	0	0	0	0	1	7536	1140	40	1		1	IDH3B	20	2640691	Silent	SNP	G	TCGA-CV-7242-01A-11D-2012-08	319526	2640691	60384829	313	42525											
MAVS	57506	broad.mit.edu	37	chr20	3841990	3841990	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctctagggacctcggacCgtcccccagacccactggag	7	6	11	17	2	1	1	0	0	1	1	4	4	3	4	6	3	0	0	6	3	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:3841990C>T	uc002wjw.3	+	4	473	c.304C>T	c.(304-306)CGT>TGT	p.R102C	MAVS_uc010zqn.1_Intron|MAVS_uc002wjx.3_5'UTR|MAVS_uc002wjy.3_Intron	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	102	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						GACCTCGGACCGTCCCCCAGA	0.453													22	64					0	0	0	0	T	3841990	T	T	3841990	3	4	234	1	0	0	0	0	1	0	0	0	9391	652	23	1	314	1	MAVS	20	3841990	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1201299	3841990	59183530	314	42526											
PLCB1	23236	broad.mit.edu	37	chr20	8737765	8737765	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagaaaatggggtgaatCacactacaaccctgacaccc	15	5	8	13	0	1	3	1	2	0	1	1	3	1	3	2	2	3	1	2	2	5	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:8737765C>A	uc002wnb.2	+	24	2599	c.2596C>A	c.(2596-2598)CAC>AAC	p.H866N	PLCB1_uc010zrb.1_Missense_Mutation_p.H765N|PLCB1_uc002wna.2_Missense_Mutation_p.H866N|PLCB1_uc002wnc.1_Missense_Mutation_p.H765N|PLCB1_uc002wnd.1_Missense_Mutation_p.H443N	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	866					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TGGGGTGAATCACACTACAAC	0.498													24	34					1.85244e-09	4.08544e-09	1	0	A	8737765	A	A	8737765	3	1	234	1	0	0	0	0	1	0	0	0	12082	826	29	2	2690	2	PLCB1	20	8737765	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	4895775	8737765	54287755	315	42527											
GZF1	64412	broad.mit.edu	37	chr20	23345471	23345471	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagagtctcaggaggtggagGtgagcagtggctcccaagtt	9	8	16	8	0	1	2	1	1	1	1	3	4	2	4	1	5	1	3	1	5	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:23345471G>T	uc010gdb.2	+	3	625	c.451G>T	c.(451-453)GTG>TTG	p.V151L	GZF1_uc002wsy.2_Missense_Mutation_p.V151L|GZF1_uc010zsq.1_Intron|GZF1_uc010zsr.1_Intron|GZF1_uc002wsz.2_Missense_Mutation_p.V151L	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	151					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					GGAGGTGGAGGTGAGCAGTGG	0.493													19	58					6.94344e-10	1.55007e-09	1	0	T	23345471	T	T	23345471	3	4	234	1	0	0	0	0	1	0	0	0	6953	1261	44	4	453	4	GZF1	20	23345471	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	14607706	23345471	39680049	316	42528											
TMEM90B	79953	broad.mit.edu	37	chr20	24524045	24524045	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctgcgctcctggggggaCggtgtggccgccgactgctg	2	8	19	12	4	0	0	0	0	0	0	1	2	1	1	3	5	3	3	3	5	0	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:24524045C>A	uc002wtw.1	+	2	945	c.312C>A	c.(310-312)GAC>GAA	p.D104E		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	104	Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						CCTGGGGGGACGGTGTGGCCG	0.632													25	61					2.79863e-10	6.34473e-10	1	0	A	24524045	A	A	24524045	3	1	234	1	0	0	0	0	1	0	0	0	16285	535	19	3	314	3	TMEM90B	20	24524045	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1178574	24524045	38501475	317	42529											
CHD6	84181	broad.mit.edu	37	chr20	40118659	40118659	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catcagccaaaatacagtttTttctgcagagagtgagaaat	15	11	8	7	0	2	2	1	1	1	2	2	4	2	2	1	0	3	2	1	0	4	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:40118659T>C	uc002xka.1	-	12	1617	c.1439A>G	c.(1438-1440)AAA>AGA	p.K480R	CHD6_uc002xkd.2_Missense_Mutation_p.K458R	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	480	Helicase ATP-binding.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				AATACAGTTTTTTCTGCAGAG	0.378													51	112					0	0	0	0	C	40118659	C	C	40118659	3	2	234	1	0	0	0	0	1	0	0	0	3344	1841	64	5	6812	5	CHD6	20	40118659	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	15594614	40118659	22906861	318	42530											
NFATC2	4773	broad.mit.edu	37	chr20	50140492	50140492	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcttggccgcgctcagaaaCttctgcggccctaccctatc	6	9	10	16	3	2	1	1	0	1	1	3	1	2	1	3	3	3	2	3	3	3	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:50140492C>G	uc002xwd.2	-	2	508	c.288G>C	c.(286-288)AAG>AAC	p.K96N	NFATC2_uc002xwc.2_Missense_Mutation_p.K96N|NFATC2_uc010zyv.1_Intron|NFATC2_uc010zyw.1_Intron|NFATC2_uc010zyx.1_Missense_Mutation_p.K76N|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Missense_Mutation_p.K76N	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	96					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					CGCTCAGAAACTTCTGCGGCC	0.657													13	57					0	0	0	0	G	50140492	G	G	50140492	3	3	234	1	0	0	0	0	1	0	0	0	10416	564	20	4	2573	4	NFATC2	20	50140492	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	10021833	50140492	12885028	319	42531											
SPO11	23626	broad.mit.edu	37	chr20	55909825	55909825	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttatctacatcaaaaggttTaattgctggcaacttaagat	14	14	7	6	0	2	1	1	0	1	1	2	1	2	1	0	2	3	4	0	2	7	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr20:55909825T>C	uc002xye.2	+	6	623	c.530T>C	c.(529-531)TTA>TCA	p.L177S	SPO11_uc002xyf.2_Missense_Mutation_p.L139S	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	177					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			TCAAAAGGTTTAATTGCTGGC	0.363								Editing_and_processing_nucleases					8	23					0	0	0	0	C	55909825	C	C	55909825	3	2	234	1	0	0	0	0	1	0	0	0	15143	1764	61	5	552	5	SPO11	20	55909825	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	5769333	55909825	7115695	320	42532											
KRTAP13-1	140258	broad.mit.edu	37	chr21	31768471	31768471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggctacctgcactacccaGcctcctcctgtggcttttcc	4	12	8	17	0	0	0	0	0	0	0	3	0	3	0	6	2	4	3	6	2	2	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr21:31768471G>A	uc002yoa.2	+	1	80	c.67G>A	c.(67-69)GCC>ACC	p.A23T		NM_181599	NP_853630	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	23						intermediate filament				ovary(1)	1						GCACTACCCAGCCTCCTCCTG	0.567													60	95					0	0	0	0	A	31768471	A	A	31768471	3	1	234	1	0	0	0	0	1	0	0	0	8561	971	34	4	69	4	KRTAP13-1	21	31768471	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08		31768471	16361424	321	42533											
SON	6651	broad.mit.edu	37	chr21	34927512	34927512	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcacccctagccgtcggaGccgcaccccaagccgccgga	7	2	11	21	6	0	0	0	0	0	0	1	2	0	2	9	2	3	2	9	2	2	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr21:34927512G>A	uc002yse.1	+	3	6024	c.5975G>A	c.(5974-5976)AGC>AAC	p.S1992N	SON_uc002ysb.1_Missense_Mutation_p.S1992N|SON_uc002ysc.2_Missense_Mutation_p.S1992N|SON_uc002ysd.2_Missense_Mutation_p.S983N|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.S983N	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1992	2-7.|2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V- V-R-R-R-S-F-S-I-S.|7 X 7 AA repeats of P-S-R-R-S-R-[TS].				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						agccgtcggagccgcacccca	0.179													16	39					0	0	0	0	A	34927512	A	A	34927512	3	1	234	1	0	0	0	0	1	0	0	0	14990	971	34	4	5985	4	SON	21	34927512	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	3159041	34927512	13202383	322	42534											
XPNPEP3	63929	broad.mit.edu	37	chr22	41265101	41265101	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agcccagcccctttacacacCcacacctcctcagaccaggt	10	6	5	20	0	1	1	1	0	0	1	2	1	2	1	7	1	3	0	7	1	1	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr22:41265101C>T	uc003azh.2	+	2	255	c.163C>T	c.(163-165)CCA>TCA	p.P55S	XPNPEP3_uc011aox.1_Missense_Mutation_p.P55S|XPNPEP3_uc003azi.2_5'UTR|XPNPEP3_uc011aoy.1_RNA|XPNPEP3_uc010gyh.1_RNA	NM_022098	NP_071381	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3,	55					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity				0						CTTTACACACCCACACCTCCT	0.423													27	92					0	0	0	0	T	41265101	T	T	41265101	3	4	234	1	0	0	0	0	1	0	0	0	17512	623	22	4	169	4	XPNPEP3	22	41265101	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08		41265101	10039465	323	42535											
RBX1	9978	broad.mit.edu	37	chr22	41349628	41349628	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccatctgcaggaaccacattAtggatctttgtaagtaattg	12	13	8	8	0	2	0	0	0	2	0	2	2	2	2	2	2	2	3	2	2	4	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr22:41349628A>G	uc003azk.2	+	2	166	c.148A>G	c.(148-150)ATG>GTG	p.M50V	XPNPEP3_uc011aoy.1_RNA	NM_014248	NP_055063	P62877	RBX1_HUMAN	ring-box 1	50					DNA repair|interspecies interaction between organisms|protein neddylation|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	Cul3-RING ubiquitin ligase complex|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytosol|nucleus|SCF ubiquitin ligase complex	NEDD8 ligase activity|protein binding|zinc ion binding			skin(1)	1						GAACCACATTATGGATCTTTG	0.453													22	86					0	0	0	0	G	41349628	G	G	41349628	3	3	234	1	0	0	0	0	1	0	0	0	13230	449	16	5	154	5	RBX1	22	41349628	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	84527	41349628	9954938	324	42536											
UPK3A	7380	broad.mit.edu	37	chr22	45689060	45689060	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgggctgcatcccaccacAgtcaccccatactcgacgat	10	6	7	18	3	1	0	1	0	0	0	3	2	2	0	5	1	2	2	5	1	1	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chr22:45689060A>T	uc003bfy.2	+	5	578	c.572_splice	c.e5-2	p.L191_splice	UPK3A_uc010gzy.2_Splice_Site_p.V70_splice	NM_006953	NP_008884	O75631	UPK3A_HUMAN	uroplakin 3A precursor						epithelial cell differentiation	endoplasmic reticulum membrane|integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		ATCCCACCACAGTCACCCCAT	0.657													11	34					0	0	0	0	T	45689060	T	T	45689060	5	4	234	1	0	0	0	0	0	0	1	0	17078	202	7	5	588	5	UPK3A	22	45689060	Splice_Site	SNP	A	TCGA-CV-7242-01A-11D-2012-08	4339432	45689060	5615506	325	42537											
MXRA5	25878	broad.mit.edu	37	chrX	3229299	3229299	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tagtctccttcctccctcatCcccacttcgttaaagtagag	8	13	5	15	1	2	1	1	0	1	1	7	1	5	1	5	0	0	2	5	0	4	5			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:3229299C>T	uc004crg.3	-	7	7102	c.6945G>A	c.(6943-6945)GGG>GGA	p.G2315G		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2315	Ig-like C2-type 7.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCTCCCTCATCCCCACTTCGT	0.547													46	87					0	0	0	0	T	3229299	T	T	3229299	2	4	234	1	0	0	0	0	0	0	0	1	10056	842	30	2		2	MXRA5	23	3229299	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08		3229299	152041261	326	42538											
FRMPD4	9758	broad.mit.edu	37	chrX	12734346	12734346	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagacagcaccatgtgtccaAaagagcaccggcacttgtac	13	6	9	13	1	0	2	0	0	0	2	1	2	1	2	3	1	3	4	3	1	3	2			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:12734346A>G	uc004cuz.1	+	15	2274	c.1768A>G	c.(1768-1770)AAA>GAA	p.K590E	FRMPD4_uc011mij.1_Missense_Mutation_p.K582E	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	590					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CATGTGTCCAAAAGAGCACCG	0.507													30	67					0	0	0	0	G	12734346	G	G	12734346	3	3	234	1	0	0	0	0	1	0	0	0	6093	15	1	5	1826	5	FRMPD4	23	12734346	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	9505047	12734346	142536214	327	42539											
TLR8	51311	broad.mit.edu	37	chrX	12939289	12939289	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgatagcctatctgacttTacatcttcccttcggacact	9	14	5	13	1	2	2	0	2	2	0	4	3	3	3	2	1	2	0	2	1	3	6			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:12939289T>C	uc004cve.2	+	2	2198	c.2130T>C	c.(2128-2130)TTT>TTC	p.F710F	TLR8_uc004cvd.2_Silent_p.F728F	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	710	LRR 21.|Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TATCTGACTTTACATCTTCCC	0.428													40	98					0	0	0	0	C	12939289	C	C	12939289	2	2	234	1	0	0	0	0	0	0	0	1	16023	1751	61	5		5	TLR8	23	12939289	Silent	SNP	T	TCGA-CV-7242-01A-11D-2012-08	204943	12939289	142331271	328	42540											
MAGEB6	158809	broad.mit.edu	37	chrX	26212351	26212351	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatatgatgtggctgccaacGgccaagatgagaaaagtcca	15	7	11	8	1	0	3	0	2	0	2	1	4	1	3	3	2	2	1	3	2	6	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:26212351G>T	uc004dbr.2	+	2	537	c.388G>T	c.(388-390)GGC>TGC	p.G130C	MAGEB6_uc010ngc.1_Intron	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	130	Ser-rich.									ovary(3)	3						GGCTGCCAACGGCCAAGATGA	0.557													36	51					3.03874e-20	7.83844e-20	1	0	T	26212351	T	T	26212351	3	4	234	1	0	0	0	0	1	0	0	0	9232	1116	39	3	390	3	MAGEB6	23	26212351	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	13273062	26212351	129058209	329	42541											
DCAF8L2	347442	broad.mit.edu	37	chrX	27766814	27766814	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggactggagaagtggtgaagCtgaatttccagatgaagaat	14	9	14	4	0	0	6	0	3	0	3	1	8	1	7	1	3	1	1	1	3	5	1			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:27766814C>G	uc011mjy.1	+	1	1889	c.1802C>G	c.(1801-1803)GCT>GGT	p.A601G		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						AGTGGTGAAGCTGAATTTCCA	0.537													5	11					0	0	0	0	G	27766814	G	G	27766814	3	3	234	1	0	0	0	0	1	0	0	0	4295	797	28	4	1804	4	DCAF8L2	23	27766814	Missense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	1554463	27766814	127503746	330	42542											
FAM47B	170062	broad.mit.edu	37	chrX	34960984	34960984	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacaggaccggccaaggtcCcaaggcatggactccaagcc	11	3	11	16	1	0	0	0	0	0	0	2	2	2	2	6	5	1	1	6	5	3	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:34960984C>A	uc004ddi.1	+	1	54	c.36C>A	c.(34-36)TCC>TCA	p.S12S		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	12										ovary(3)|breast(1)	4						GGCCAAGGTCCCAAGGCATGG	0.632													7	15					0.000157383	0.000304747	1	0	A	34960984	A	A	34960984	2	1	234	1	0	0	0	0	0	0	0	1	5602	610	22	4		4	FAM47B	23	34960984	Silent	SNP	C	TCGA-CV-7242-01A-11D-2012-08	7194170	34960984	120309576	331	42543											
DGKK	139189	broad.mit.edu	37	chrX	50119165	50119165	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgctcaggtcattaagtCtgtaataaagcaaggacaga	14	11	9	7	0	4	1	2	0	2	1	4	2	4	2	0	2	2	3	0	2	5	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:50119165C>A	uc010njr.1	-	25	3333	c.3273_splice	c.e25-1	p.K1091_splice		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					GTCATTAAGTCTGTAATAAAG	0.478													13	24					4.7546e-09	1.02688e-08	1	0	A	50119165	A	A	50119165	5	1	234	1	0	0	0	0	0	0	1	0	4494	927	32	2	563	2	DGKK	23	50119165	Splice_Site	SNP	C	TCGA-CV-7242-01A-11D-2012-08	15158181	50119165	105151395	332	42544											
AR	367	broad.mit.edu	37	chrX	66765161	66765161	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccagtttgctgctgctgcAgcagcagcagcagcagcagc	8	6	13	14	1	0	0	0	0	0	0	0	0	0	0	1	0	11	11	1	0	0	1	rs5902610		TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:66765161A>T	uc004dwu.1	+	1	1288	c.173A>T	c.(172-174)CAG>CTG	p.Q58L	AR_uc011mpd.1_Missense_Mutation_p.Q58L|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.Q58L	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	58	Modulating.|Poly-Gln.|Gln-rich.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CTGCTGCTgcagcagcagcag	0.328									Androgen_Insensitivity_Syndrome				4	37					0	0	0	0	T	66765161	T	T	66765161	3	4	234	1	0	0	0	0	1	0	0	0	836	188	7	5	175	5	AR	23	66765161	Missense_Mutation	SNP	A	TCGA-CV-7242-01A-11D-2012-08	16645996	66765161	88505399	333	42545											
ITM2A	9452	broad.mit.edu	37	chrX	78616913	78616913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccaaggttactaacatcacGaatttcctccacagcaacta	14	9	5	13	1	1	0	1	0	0	0	3	1	3	0	3	1	4	2	3	1	6	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:78616913G>A	uc004edh.2	-	5	951	c.616C>T	c.(616-618)CGT>TGT	p.R206C	ITM2A_uc011mqr.1_Missense_Mutation_p.R162C	NM_004867	NP_004858	O43736	ITM2A_HUMAN	integral membrane protein 2A	206	BRICHOS.					integral to membrane	protein binding			lung(2)	2						CTAACATCACGAATTTCCTCC	0.398													22	41					0	0	0	0	A	78616913	A	A	78616913	3	1	234	1	0	0	0	0	1	0	0	0	7951	1058	37	1	183	1	ITM2A	23	78616913	Missense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	11851752	78616913	76653647	334	42546											
TGIF2LX	90316	broad.mit.edu	37	chrX	89177112	89177112	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctgcggacggcccggctGagacccaaagcccggtggaa	8	3	15	15	5	0	1	0	1	0	1	0	4	0	3	4	5	2	2	4	5	2	0			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:89177112G>T	uc004efe.2	+	2	77	c.28G>T	c.(28-30)GAG>TAG	p.E10*		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	10						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CGGCCCGGCTGAGACCCAAAG	0.522													26	47					4.87955e-14	1.16028e-13	1	0	T	89177112	T	T	89177112	4	4	234	1	0	0	0	0	0	1	0	0	15893	1291	45	2	30	2	TGIF2LX	23	89177112	Nonsense_Mutation	SNP	G	TCGA-CV-7242-01A-11D-2012-08	10560199	89177112	66093448	335	42547											
DOCK11	139818	broad.mit.edu	37	chrX	117817178	117817178	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatctgacattatccatgagCaggcaagtattagggtgact	12	12	10	7	0	1	3	0	3	1	0	2	3	2	3	1	2	1	3	1	2	5	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:117817178C>T	uc004eqp.2	+	52	6163	c.6100C>T	c.(6100-6102)CAG>TAG	p.Q2034*	DOCK11_uc004eqq.2_Nonsense_Mutation_p.Q1813*	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	2034					blood coagulation	cytosol	GTP binding			ovary(3)	3						TATCCATGAGCAGGCAAGTAT	0.358													29	43					0	0	0	0	T	117817178	T	T	117817178	4	4	234	1	0	0	0	0	0	1	0	0	4708	711	25	4	6306	4	DOCK11	23	117817178	Nonsense_Mutation	SNP	C	TCGA-CV-7242-01A-11D-2012-08	28640066	117817178	37453382	336	42548											
CUL4B	8450	broad.mit.edu	37	chrX	119677600	119677600	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgggtggtctgatctaagTaagtaataagtctgtctgct	10	14	11	6	0	4	1	0	1	4	0	4	1	4	1	0	2	1	3	0	2	4	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:119677600T>G	uc004esw.2	-	10	1729	c.1292A>C	c.(1291-1293)TAC>TCC	p.Y431S	CUL4B_uc010nqq.2_Missense_Mutation_p.Y130S|CUL4B_uc004esv.2_Missense_Mutation_p.Y413S	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	431					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						CTGATCTAAGTAAGTAATAAG	0.348													24	42					0	0	0	0	G	119677600	G	G	119677600	3	3	234	1	0	0	0	0	1	0	0	0	4075	1638	57	5	1501	5	CUL4B	23	119677600	Missense_Mutation	SNP	T	TCGA-CV-7242-01A-11D-2012-08	1860422	119677600	35592960	337	42549											
FRMD7	90167	broad.mit.edu	37	chrX	131212467	131212468	+	Missense_Mutation	DNP	AG	GT	GT																															ctttcagctggcttcattgcAgtgggctctacatagctatg																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:131212467_131212468AG>GT	uc004ewn.2	-	12	1755_1756	c.1577_1578CT>AC	c.(1576-1578)ACT>AAC	p.T526N	FRMD7_uc011muy.1_Missense_Mutation_p.T511N	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	526					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GCTTCATTGCAGTGGGCTCTAC	0.495													68	129					0	0	0	0	GT	131212468	GT	GT	131212467	3	3	234	1	0	0	0	0	1	0	0	0	6089	175	7	5	570	5	FRMD7	23	131212467	Missense_Mutation	DNP	AG	TCGA-CV-7242-01A-11D-2012-08	11534867	131212467	24058093	338	42550											
MAGEC1	9947	broad.mit.edu	37	chrX	140995218	140995219	+	Missense_Mutation	DNP	CC	AA	AA																															atgcactcccaatctcctctCcagagtcctgagagtgctcc																										TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:140995218_140995219CC>AA	uc004fbt.2	+	4	2314_2315	c.2028_2029CC>AA	c.(2026-2031)CTCCAG>CTAAAG	p.Q677K	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	677							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AATCTCCTCTCCAGAGTCCTGA	0.564										HNSCC(15;0.026)			51	98					0	0	0	0	AA	140995219	AA	AA	140995218	3	1	234	1	0	0	0	0	1	0	0	0	9233	842	30	2	2034	2	MAGEC1	23	140995218	Missense_Mutation	DNP	CC	TCGA-CV-7242-01A-11D-2012-08	9782751	140995218	14275342	339	42551											
TKTL1	8277	broad.mit.edu	37	chrX	153533683	153533683	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcatgtagcagttcttcTgagatcatgtctgtgctgtt	8	16	9	8	0	5	1	2	1	3	1	5	2	5	1	0	0	2	5	0	0	1	4			TCGA-CV-7242-01A-11D-2012-08	TCGA-CV-7242-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9e07a1bc-f7c7-4cb4-b3b1-92162a79de0e	b097d6fa-5fbe-46ca-867e-17d5cb86e299	g.chrX:153533683T>A	uc004fkg.2	+	2	348	c.162T>A	c.(160-162)TCT>TCA	p.S54S	TKTL1_uc011mzl.1_Silent_p.S48S|TKTL1_uc011mzm.1_Silent_p.S54S|TKTL1_uc004fkh.2_5'UTR	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	54					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCAGTTCTTCTGAGATCATGT	0.498													21	43					0	0	0	0	A	153533683	A	A	153533683	2	1	234	1	0	0	0	0	0	0	0	1	16001	1567	55	5		5	TKTL1	23	153533683	Silent	SNP	T	TCGA-CV-7242-01A-11D-2012-08	12538465	153533683	1736877	340	42552											
VPS13D	55187	broad.mit.edu	37	chr1	12428620	12428620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acacagatcagttacctcctCctttccgaattgacaacttt	11	13	4	13	1	1	2	1	1	0	1	4	3	4	2	4	0	2	1	4	0	3	4			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr1:12428620C>T	uc001atv.2	+	53	10687	c.10546C>T	c.(10546-10548)CCT>TCT	p.P3516S	VPS13D_uc001atw.2_Missense_Mutation_p.P3491S|VPS13D_uc001atx.2_Missense_Mutation_p.P2703S|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3515					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GTTACCTCCTCCTTTCCGAAT	0.463													38	76					0	0	0	0	T	12428620	T	T	12428620	3	4	235	1	0	0	0	0	1	0	0	0	17260	855	30	2	10752	2	VPS13D	1	12428620	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08		12428620	236822001	1	42553											
KIAA0467	23334	broad.mit.edu	37	chr1	43905594	43905594	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgattggatgtgtgggaaaAggggaacattagtattgtgc	11	12	15	3	1	0	0	0	0	0	0	1	4	0	3	0	4	2	1	0	4	5	4			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr1:43905594A>G	uc001cjk.1	+	36	4850	c.4388A>G	c.(4387-4389)AAG>AGG	p.K1463R		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2362						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GTGTGGGAAAAGGGGAACATT	0.577													3	84					0	0	0	0	G	43905594	G	G	43905594	3	3	235	1	0	0	0	0	1	0	0	0	8217	72	3	5	4522	5	KIAA0467	1	43905594	Missense_Mutation	SNP	A	TCGA-CV-7243-01A-11D-2012-08	31476974	43905594	205345027	2	42554											
CKS1B	1163	broad.mit.edu	37	chr1	154947264	154947264	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attcggacaaatacgacgacGaggagtttgagtatcggtta	13	10	12	6	5	0	1	0	1	0	0	2	6	0	3	0	3	1	3	0	3	4	5			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr1:154947264G>A	uc001fgb.2	+	1	147	c.43G>A	c.(43-45)GAG>AAG	p.E15K	SHC1_uc001ffx.2_5'Flank|SHC1_uc001ffy.2_5'Flank|CKS1B_uc001fga.2_RNA|hsa-mir-4258|MI0015857_5'Flank	NM_001826	NP_001817	P61024	CKS1_HUMAN	CDC28 protein kinase 1B	15					cell division|cell proliferation|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	nucleoplasm	cyclin-dependent protein kinase regulator activity|protein binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ATACGACGACGAGGAGTTTGA	0.547													6	34					0	0	0	0	A	154947264	A	A	154947264	3	1	235	1	0	0	0	0	1	0	0	0	3467	1059	37	1	45	1	CKS1B	1	154947264	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	111041670	154947264	94303357	3	42555											
PAPPA2	60676	broad.mit.edu	37	chr1	176659381	176659381	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgtctttaaaggagtcaGtgaaagagaatcctgcaatg	14	10	10	7	0	2	2	1	1	1	1	3	4	3	3	2	1	1	1	2	1	5	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr1:176659381G>T	uc001gkz.2	+	5	3410	c.2246G>T	c.(2245-2247)AGT>ATT	p.S749I	PAPPA2_uc001gky.1_Missense_Mutation_p.S749I|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	749	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AAAGGAGTCAGTGAAAGAGAA	0.547													19	147					5.03518e-11	4.8114e-10	1	0	T	176659381	T	T	176659381	3	4	235	1	0	0	0	0	1	0	0	0	11487	1029	36	4	2260	4	PAPPA2	1	176659381	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	21712117	176659381	72591240	4	42556											
SOX11	6664	broad.mit.edu	37	chr2	5833121	5833121	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggcaagcgctggaaaatgCtgaaggacagcgagaagatc	14	5	15	7	2	0	3	0	1	0	2	1	6	0	5	0	3	3	3	0	3	5	0			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr2:5833121C>T	uc002qyj.2	+	1	323	c.268C>T	c.(268-270)CTG>TTG	p.L90L		NM_003108	NP_003099	P35716	SOX11_HUMAN	SRY-box 11	90	HMG box.				cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(3)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		CTGGAAAATGCTGAAGGACAG	0.587													15	48					0	0	0	0	T	5833121	T	T	5833121	2	4	235	1	0	0	0	0	0	0	0	1	15006	796	28	4		4	SOX11	2	5833121	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08		5833121	237366252	5	42557											
ZNF512	84450	broad.mit.edu	37	chr2	27830785	27830785	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agagtcaaagagtgggggccGagttcagagacgttctgcca	11	7	15	8	2	3	3	2	0	1	3	3	5	3	3	2	2	1	2	2	2	1	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr2:27830785G>A	uc002rla.2	+	10	1097	c.1010G>A	c.(1009-1011)CGA>CAA	p.R337Q	ZNF512_uc010ylv.1_Missense_Mutation_p.R258Q|ZNF512_uc010ylw.1_Missense_Mutation_p.R308Q|ZNF512_uc002rlb.2_Missense_Mutation_p.R258Q|ZNF512_uc010ylx.1_Missense_Mutation_p.R258Q|ZNF512_uc002rlc.2_Missense_Mutation_p.R258Q|ZNF512_uc010yly.1_RNA|ZNF512_uc010ylz.1_Missense_Mutation_p.R230Q	NM_032434	NP_115810	Q96ME7	ZN512_HUMAN	zinc finger protein 512	337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					AGTGGGGGCCGAGTTCAGAGA	0.512													12	49					0	0	0	0	A	27830785	A	A	27830785	3	1	235	1	0	0	0	0	1	0	0	0	18023	1058	37	1	1048	1	ZNF512	2	27830785	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	21997664	27830785	215368588	6	42558											
CCDC88A	55704	broad.mit.edu	37	chr2	55571557	55571557	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagttctctttttctaattCatgtaatttatcagaacgag	12	18	5	6	1	4	1	2	0	2	1	5	2	4	1	0	0	1	2	0	0	5	9			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr2:55571557C>T	uc002ryv.2	-	11	1977	c.1135G>A	c.(1135-1137)GAA>AAA	p.E379K	CCDC88A_uc010yoz.1_Missense_Mutation_p.E379K|CCDC88A_uc010ypa.1_Missense_Mutation_p.E379K|CCDC88A_uc010ypb.1_Missense_Mutation_p.E281K	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	379	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TTTTCTAATTCATGTAATTTA	0.318													8	58					0	0	0	0	T	55571557	T	T	55571557	3	4	235	1	0	0	0	0	1	0	0	0	2876	835	29	2	4568	2	CCDC88A	2	55571557	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	27740772	55571557	187627816	7	42559											
OBSL1	23363	broad.mit.edu	37	chr2	220432935	220432935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcagccgctggtcctcaCggaaccaggccgtggggatg	7	5	16	13	3	1	0	1	0	0	0	2	2	2	2	4	5	3	3	4	5	1	0			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr2:220432935C>T	uc010fwk.2	-	2	1181	c.1124G>A	c.(1123-1125)CGT>CAT	p.R375H	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Missense_Mutation_p.R375H|OBSL1_uc002vmj.2_Translation_Start_Site	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	375	Ig-like 4.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CTGGTCCTCACGGAACCAGGC	0.637											OREG0003988	type=REGULATORY REGION|Gene=OBSL1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	9	31					0	0	0	0	T	220432935	T	T	220432935	3	4	235	1	0	0	0	0	1	0	0	0	10867	536	19	1	4798	1	OBSL1	2	220432935	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	164861378	220432935	22766438	8	42560											
SLC6A6	6533	broad.mit.edu	37	chr3	14499524	14499524	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaaatgggacctcgctctCtgccttcttttagtctggct	5	15	9	12	1	3	1	0	1	3	0	5	2	3	2	2	2	1	2	2	2	2	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr3:14499524C>T	uc010heg.2	+	13	957	c.666C>T	c.(664-666)CTC>CTT	p.L222L	SLC6A6_uc010hef.1_RNA|SLC6A6_uc003byq.2_Silent_p.L222L|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	222	Helical; Name=4; (Potential).				cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						ACCTCGCTCTCTGCCTTCTTT	0.547													25	101					0	0	0	0	T	14499524	T	T	14499524	2	4	235	1	0	0	0	0	0	0	0	1	14752	900	32	2		2	SLC6A6	3	14499524	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08		14499524	183522906	9	42561											
IL17RB	55540	broad.mit.edu	37	chr3	53883814	53883814	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatgtaagctgggtactccGggcagatggtaagtttgcat	10	11	14	6	1	0	1	0	0	0	1	1	2	1	1	1	3	3	7	1	3	4	4	rs145364776	by1000genomes	TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr3:53883814G>A	uc003dha.2	+	3	257	c.218G>A	c.(217-219)CGG>CAG	p.R73Q		NM_018725	NP_061195	Q9NRM6	I17RB_HUMAN	interleukin 17B receptor precursor	73	Extracellular (Potential).				defense response|regulation of cell growth	extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)		TGGGTACTCCGGGCAGATGGT	0.333													44	70					0	0	0	0	A	53883814	A	A	53883814	3	1	235	1	0	0	0	0	1	0	0	0	7679	1116	39	1	228	1	IL17RB	3	53883814	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	39384290	53883814	144138616	10	42562											
OR5H15	403274	broad.mit.edu	37	chr3	97887689	97887689	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttggtctgattgctgtcaTctggaaagaccctcaccttc	7	14	8	12	0	5	2	2	1	3	1	6	3	5	3	2	2	1	1	2	2	1	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr3:97887689T>C	uc011bgu.1	+	1	146	c.146T>C	c.(145-147)ATC>ACC	p.I49T		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	49	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATTGCTGTCATCTGGAAAGAC	0.423													87	146					0	0	0	0	C	97887689	C	C	97887689	3	2	235	1	0	0	0	0	1	0	0	0	11215	1435	50	5	148	5	OR5H15	3	97887689	Missense_Mutation	SNP	T	TCGA-CV-7243-01A-11D-2012-08	44003875	97887689	100134741	11	42563											
UCHL1	7345	broad.mit.edu	37	chr4	41265298	41265298	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacaacgtggatggccacctCtatgaacttggtatgtttta	11	13	9	8	1	1	1	0	1	1	0	1	2	1	2	2	3	3	2	2	3	6	5			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr4:41265298C>T	uc003gvo.2	+	7	612	c.516C>T	c.(514-516)CTC>CTT	p.L172L	UCHL1_uc003gvp.2_Silent_p.L91L|UCHL1_uc003gvq.2_Silent_p.L91L|UCHL1_uc003gvr.2_Silent_p.L91L|UCHL1_uc003gvs.2_Silent_p.L91L	NM_004181	NP_004172	P09936	UCHL1_HUMAN	ubiquitin carboxyl-terminal esterase L1	172					cell death|negative regulation of MAP kinase activity|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus|plasma membrane	alpha-2A adrenergic receptor binding|cysteine-type endopeptidase activity|ligase activity|omega peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity			central_nervous_system(1)|skin(1)	2						ATGGCCACCTCTATGAACTTG	0.343													12	90					0	0	0	0	T	41265298	T	T	41265298	2	4	235	1	0	0	0	0	0	0	0	1	16988	900	32	2		2	UCHL1	4	41265298	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08		41265298	149888978	12	42564											
C4orf31	79625	broad.mit.edu	37	chr4	121958733	121958733	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatataaaatactcaacatcAttgcctttgtaggagaataa	17	12	6	6	0	2	1	2	0	0	1	2	3	2	1	1	1	3	1	1	1	8	7			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr4:121958733A>G	uc003idq.1	-	4	920	c.393T>C	c.(391-393)AAT>AAC	p.N131N		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	131											0						ACTCAACATCATTGCCTTTGT	0.403													15	63					0	0	0	0	G	121958733	G	G	121958733	2	3	235	1	0	0	0	0	0	0	0	1	2271	214	8	5		5	C4orf31	4	121958733	Silent	SNP	A	TCGA-CV-7243-01A-11D-2012-08	80693435	121958733	69195543	13	42565											
PCDH10	57575	broad.mit.edu	37	chr4	134072411	134072411	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggtgagtgagggcgcggcGcccggcactgtggtggccct	3	6	20	12	5	0	2	0	2	0	0	0	2	0	2	2	6	0	1	2	6	0	0			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr4:134072411G>A	uc003iha.2	+	1	1942	c.1116G>A	c.(1114-1116)GCG>GCA	p.A372A	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.A372A	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	372	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		AGGGCGCGGCGCCCGGCACTG	0.617													13	95					0	0	0	0	A	134072411	A	A	134072411	2	1	235	1	0	0	0	0	0	0	0	1	11561	1074	38	1		1	PCDH10	4	134072411	Silent	SNP	G	TCGA-CV-7243-01A-11D-2012-08	12113678	134072411	57081865	14	42566											
CCRN4L	25819	broad.mit.edu	37	chr4	139965866	139965866	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggaagaaaggaaatgtctCatcctggaagaaatcctggc	14	8	12	7	0	1	2	1	0	1	2	4	5	3	5	2	4	0	0	2	4	5	0			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr4:139965866C>T	uc003ihl.2	+	3	727	c.534C>T	c.(532-534)CTC>CTT	p.L178L		NM_012118	NP_036250	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like	178					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_hematologic(180;0.162)					GGAAATGTCTCATCCTGGAAG	0.463													21	74					0	0	0	0	T	139965866	T	T	139965866	2	4	235	1	0	0	0	0	0	0	0	1	2966	813	29	2		2	CCRN4L	4	139965866	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08	5893455	139965866	51188410	15	42567											
NR3C2	4306	broad.mit.edu	37	chr4	149356634	149356634	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatagtctttatcatccataAaggaaaaatacgagccatcc	17	10	5	9	1	2	0	1	0	1	0	4	2	4	1	3	1	2	0	3	1	8	5			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr4:149356634A>T	uc003ilj.3	-	2	1713	c.1379T>A	c.(1378-1380)TTT>TAT	p.F460Y	NR3C2_uc003ilk.3_Missense_Mutation_p.F460Y|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	460	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	ATCATCCATAAAGGAAAAATA	0.418													10	52					0	0	0	0	T	149356634	T	T	149356634	3	4	235	1	0	0	0	0	1	0	0	0	10685	14	1	5	1607	5	NR3C2	4	149356634	Missense_Mutation	SNP	A	TCGA-CV-7243-01A-11D-2012-08	9390768	149356634	41797642	16	42568											
TRIML2	205860	broad.mit.edu	37	chr4	189012783	189012783	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcagaggggggaagaccCagagagtccactcggtcccc	9	7	13	12	1	1	3	1	0	0	3	4	5	3	4	4	4	0	0	4	4	1	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr4:189012783C>A	uc003izl.2	-	7	944	c.908G>T	c.(907-909)TGG>TTG	p.W303L	TRIML2_uc003izj.1_Missense_Mutation_p.W131L|TRIML2_uc003izk.1_Missense_Mutation_p.W111L|TRIML2_uc011cle.1_Missense_Mutation_p.W378L	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	303	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GGGGAAGACCCAGAGAGTCCA	0.552													35	124					8.4185e-14	8.21021e-13	1	0	A	189012783	A	A	189012783	3	1	235	1	0	0	0	0	1	0	0	0	16618	595	21	4	259	4	TRIML2	4	189012783	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	39656149	189012783	2141493	17	42569											
RASA1	5921	broad.mit.edu	37	chr5	86674234	86674234	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagccactaccctatttcGagccacaacacttgcaagca	13	8	6	14	1	0	1	0	1	0	0	1	2	0	1	3	0	6	2	3	0	5	4			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr5:86674234G>T	uc003kiw.2	+	18	2484	c.2366G>T	c.(2365-2367)CGA>CTA	p.R789L	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.R612L|RASA1_uc011ctv.1_Missense_Mutation_p.R622L|RASA1_uc011ctw.1_Missense_Mutation_p.R623L|RASA1_uc010jaw.2_Missense_Mutation_p.R611L	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	789	Ras-GAP.			R -> A (in Ref. 4; AA sequence).	cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		ACCCTATTTCGAGCCACAACA	0.353													16	25					1.67942e-08	1.58873e-07	1	0	T	86674234	T	T	86674234	3	4	235	1	0	0	0	0	1	0	0	0	13125	1058	37	3	2448	3	RASA1	5	86674234	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08		86674234	94241026	18	42570											
PCDHA3	56145	broad.mit.edu	37	chr5	140182317	140182317	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctacgtgtcggtacacgCggagagcggcaaggtgtacg	9	6	17	9	6	0	1	0	0	0	1	1	3	0	1	0	4	5	4	0	4	4	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr5:140182317C>T	uc003lhf.2	+	1	1535	c.1535C>T	c.(1534-1536)GCG>GTG	p.A512V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.A512V	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	512	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGTACACGCGGAGAGCGGC	0.706													7	124					0	0	0	0	T	140182317	T	T	140182317	3	4	235	1	0	0	0	0	1	0	0	0	11579	768	27	1	1537	1	PCDHA3	5	140182317	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	53508083	140182317	40732943	19	42571											
HIST1H2BK	85236	broad.mit.edu	37	chr6	27114379	27114379	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgttcgaagatgtcgttgaCgaaggagttcatgattccca	10	11	12	8	4	1	3	1	2	0	1	4	6	2	4	1	1	0	3	1	1	2	4			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr6:27114379C>T	uc003nix.1	-	1	241	c.199G>A	c.(199-201)GTC>ATC	p.V67I	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	67					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						ATGTCGTTGACGAAGGAGTTC	0.592													18	254					0	0	0	0	T	27114379	T	T	27114379	3	4	235	1	0	0	0	0	1	0	0	0	7189	536	19	1	185	1	HIST1H2BK	6	27114379	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08		27114379	144000688	20	42572											
HSP90AB1	3326	broad.mit.edu	37	chr6	44221057	44221058	+	Missense_Mutation	DNP	CC	AA	AA																															ctgctatcttctggcttttcCcttgaggatccccagaccca																										TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr6:44221057_44221058CC>AA	uc003oxa.1	+	11	2091_2092	c.2007_2008CC>AA	c.(2005-2010)TCCCTT>TCAATT	p.L670I	HSP90AB1_uc011dvr.1_Missense_Mutation_p.L660I|HSP90AB1_uc003oxb.1_Missense_Mutation_p.L670I|HSP90AB1_uc011dvs.1_Missense_Mutation_p.L490I|HSP90AB1_uc003oxc.1_Missense_Mutation_p.L308I	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	670					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTGGCTTTTCCCTTGAGGATCC	0.525													10	608					0	0	0	0	AA	44221058	AA	AA	44221057	3	1	235	1	0	0	0	0	1	0	0	0	7441	610	22	4	2045	4	HSP90AB1	6	44221057	Missense_Mutation	DNP	CC	TCGA-CV-7243-01A-11D-2012-08	17106678	44221057	126894010	21	42573											
HIVEP2	3097	broad.mit.edu	37	chr6	143092672	143092672	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctccctggacggtgatacCgtggaggctgctgctcccga	5	9	13	14	3	1	1	0	1	1	0	3	4	2	3	3	4	3	3	3	4	1	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr6:143092672C>T	uc003qjd.2	-	5	3947	c.3204G>A	c.(3202-3204)ACG>ACA	p.T1068T		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1068					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		ACGGTGATACCGTGGAGGCTG	0.557													9	35					0	0	0	0	T	143092672	T	T	143092672	2	4	235	1	0	0	0	0	0	0	0	1	7226	639	23	1		1	HIVEP2	6	143092672	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08	98871615	143092672	28022395	22	42574											
UTRN	7402	broad.mit.edu	37	chr6	144769778	144769778	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggggatgtctcagattcctCagaaggaccttttggagact	9	12	12	8	0	2	3	2	0	1	3	4	6	3	5	2	4	0	0	2	4	1	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr6:144769778C>T	uc003qkt.2	+	16	2037	c.1945C>T	c.(1945-1947)CAG>TAG	p.Q649*	UTRN_uc010khq.1_Nonsense_Mutation_p.Q649*	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	649	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TCAGATTCCTCAGAAGGACCT	0.378													10	78					0	0	0	0	T	144769778	T	T	144769778	4	4	235	1	0	0	0	0	0	1	0	0	17171	827	29	2	2007	2	UTRN	6	144769778	Nonsense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	1677106	144769778	26345289	23	42575											
STYXL1	51657	broad.mit.edu	37	chr7	75634686	75634686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgaagaccttccctggcaCgatttcaatggggtatggct	10	10	11	10	2	1	1	1	0	0	1	2	3	2	1	2	4	1	3	2	4	4	3	rs147059565		TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr7:75634686C>T	uc003uej.3	-	6	663	c.490G>A	c.(490-492)GTG>ATG	p.V164M	STYXL1_uc003uef.2_Translation_Start_Site|STYXL1_uc011kgf.1_Missense_Mutation_p.V26M|STYXL1_uc011kgg.1_Missense_Mutation_p.V16M|STYXL1_uc003ueh.2_Missense_Mutation_p.V26M|STYXL1_uc003uek.3_Missense_Mutation_p.V68M|STYXL1_uc003uel.2_Missense_Mutation_p.V164M|STYXL1_uc003uem.2_Missense_Mutation_p.V164M|STYXL1_uc010ldg.1_RNA|STYXL1_uc010ldh.1_Missense_Mutation_p.V164M|STYXL1_uc003uen.1_Missense_Mutation_p.V164M	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	164	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						TTCCCTGGCACGATTTCAATG	0.478													19	49					0	0	0	0	T	75634686	T	T	75634686	3	4	235	1	0	0	0	0	1	0	0	0	15427	536	19	1	467	1	STYXL1	7	75634686	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08		75634686	83503977	24	42576											
PCLO	27445	broad.mit.edu	37	chr7	82584839	82584839	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagctcgaagttcatctttGtctttctttgattttttact	6	22	6	7	1	4	2	1	2	3	0	5	3	4	2	0	0	2	2	0	0	2	7			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr7:82584839G>T	uc003uhx.2	-	5	5719	c.5430C>A	c.(5428-5430)GAC>GAA	p.D1810E	PCLO_uc003uhv.2_Missense_Mutation_p.D1810E	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1741					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTTCATCTTTGTCTTTCTTTG	0.393													32	145					5.60225e-13	5.40789e-12	1	0	T	82584839	T	T	82584839	3	4	235	1	0	0	0	0	1	0	0	0	11637	1368	48	4	10099	4	PCLO	7	82584839	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	6950153	82584839	76553824	25	42577											
DPP6	1804	broad.mit.edu	37	chr7	154681011	154681011	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtagcccatcgagtctccgcGctggaagaacagcagttcct	9	8	11	13	3	1	1	0	0	1	1	4	3	2	2	3	1	3	4	3	1	3	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr7:154681011G>A	uc003wlk.2	+	24	2463	c.2334G>A	c.(2332-2334)GCG>GCA	p.A778A	DPP6_uc003wli.2_Silent_p.A714A|DPP6_uc003wlm.2_Silent_p.A716A|DPP6_uc011kvq.1_Silent_p.A671A	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	778	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GAGTCTCCGCGCTGGAAGAAC	0.537													5	17					0	0	0	0	A	154681011	A	A	154681011	2	1	235	1	0	0	0	0	0	0	0	1	4752	1074	38	1		1	DPP6	7	154681011	Silent	SNP	G	TCGA-CV-7243-01A-11D-2012-08	72096172	154681011	4457652	26	42578											
IKBKB	3551	broad.mit.edu	37	chr8	42175203	42175203	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccacacattggacatggAtcttgtttttctctttgaca	8	15	9	9	0	2	1	0	1	2	0	3	3	2	3	1	3	0	1	1	3	0	5			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr8:42175203A>T	uc003xow.1	+	12	1331	c.1154A>T	c.(1153-1155)GAT>GTT	p.D385V	IKBKB_uc010lxh.1_Missense_Mutation_p.D280V|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.D162V|IKBKB_uc003xox.1_Missense_Mutation_p.D106V|IKBKB_uc011lcp.1_Intron|IKBKB_uc011lcq.1_Missense_Mutation_p.D383V|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.D326V	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	385					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	TTGGACATGGATCTTGTTTTT	0.413													13	49					0	0	0	0	T	42175203	T	T	42175203	3	4	235	1	0	0	0	0	1	0	0	0	7650	333	12	5	1196	5	IKBKB	8	42175203	Missense_Mutation	SNP	A	TCGA-CV-7243-01A-11D-2012-08		42175203	104188819	27	42579											
CDKN2A	1029	broad.mit.edu	37	chr9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcagctccgccactcGggcgctgcccatcatcatga	8	6	10	17	3	2	1	2	1	0	0	4	1	3	1	3	1	4	4	3	1	0	0	rs121913387		TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	7					0	0	0	0	A	21971186	A	A	21971186	4	1	235	1	0	0	0	0	0	1	0	0	3176	1125	39	1	306	1	CDKN2A	9	21971186	Nonsense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08		21971186	119242245	28	42580											
SIRT1	23411	broad.mit.edu	37	chr10	69644867	69644869	+	In_Frame_Del	DEL	GAG	-	-																															aagacgacgacgacgagggcGaggaggaggaagaggcggcg																										TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr10:69644867_69644869delGAG	uc001jnd.2	+	1	441_443	c.388_390delGAG	c.(388-390)GAGdel	p.E134del	SIRT1_uc010qis.1_5'Flank|SIRT1_uc009xpp.2_5'Flank	NM_012238	NP_036370	Q96EB6	SIRT1_HUMAN	sirtuin 1 isoform a	134	Interaction with HIST1H1E.|Poly-Glu.				apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding				0						cgacgagggcgaggaggaggaag	0.507													---	---	---								-	69644869	-	-	69644867	7	5	235	1	0	1	0	1	0	0	0	0	14402	1059	37	0	390	0	SIRT1	10	69644867	In_Frame_Del	DEL	GAG	TCGA-CV-7243-01A-11D-2012-08		69644867	65889880	29	42581											
MGMT	4255	broad.mit.edu	37	chr10	131565233	131565233	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caagggagcgggagctacctCgggctccccgcctgctggcc	5	5	15	16	3	0	0	0	0	0	0	2	2	1	2	5	4	4	3	5	4	2	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr10:131565233C>T	uc001lkh.2	+	5	715	c.689C>T	c.(688-690)TCG>TTG	p.S230L		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	199										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		GGAGCTACCTCGGGCTCCCCG	0.632								Direct_reversal_of_damage					6	26					0	0	0	0	T	131565233	T	T	131565233	3	4	235	1	0	0	0	0	1	0	0	0	9610	893	31	1	707	1	MGMT	10	131565233	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	61920366	131565233	3969514	30	42582											
OR8J3	81168	broad.mit.edu	37	chr11	55904668	55904671	+	Frame_Shift_Del	DEL	TGAT	-	-																															gtgcaatatcacagtaaaaaTgattgattatattagaagag																										TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr11:55904668_55904671delTGAT	uc010riz.1	-	1	524_527	c.524_527delATCA	c.(523-528)AATCATfs	p.N175fs		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	175_176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					ACAGTAAAAATGATTGATTATATT	0.358													---	---	---								-	55904671	-	-	55904668	7	5	235	1	0	1	0	1	0	0	0	0	11296	1464	51	0	422	0	OR8J3	11	55904668	Frame_Shift_Del	DEL	TGAT	TCGA-CV-7243-01A-11D-2012-08		55904668	79101848	31	42583											
OR5AR1	219493	broad.mit.edu	37	chr11	56431686	56431686	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggttccaatatcatcaaTcatttcttctgcgaaatccc	10	15	5	11	1	5	0	3	0	2	0	7	1	7	0	2	1	1	1	2	1	4	4			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr11:56431686T>G	uc010rjm.1	+	1	525	c.525T>G	c.(523-525)AAT>AAG	p.N175K		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATATCATCAATCATTTCTTCT	0.483													39	246					0	0	0	0	G	56431686	G	G	56431686	3	3	235	1	0	0	0	0	1	0	0	0	11199	1432	50	5	527	5	OR5AR1	11	56431686	Missense_Mutation	SNP	T	TCGA-CV-7243-01A-11D-2012-08	527018	56431686	78574830	32	42584											
OR6Q1	219952	broad.mit.edu	37	chr11	57798843	57798843	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccactatggggcttttgTgtcctggggcacctgcatcc	4	13	11	13	0	1	0	0	0	1	0	4	0	3	0	4	4	1	3	4	4	1	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr11:57798843T>G	uc010rjz.1	+	1	419	c.419T>G	c.(418-420)GTG>GGG	p.V140G	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	140	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				GGGGCTTTTGTGTCCTGGGGC	0.507													20	124					0	0	0	0	G	57798843	G	G	57798843	3	3	235	1	0	0	0	0	1	0	0	0	11262	1696	59	5	421	5	OR6Q1	11	57798843	Missense_Mutation	SNP	T	TCGA-CV-7243-01A-11D-2012-08	1367157	57798843	77207673	33	42585											
ARHGEF12	23365	broad.mit.edu	37	chr11	120348886	120348886	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagagatttgggattagaatCtaccttaatatcgtcaaaac	15	12	7	7	1	2	2	1	0	1	2	3	4	2	3	1	1	2	0	1	1	7	5			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr11:120348886C>G	uc001pxl.1	+	37	3561	c.3554C>G	c.(3553-3555)TCT>TGT	p.S1185C	ARHGEF12_uc009zat.2_Missense_Mutation_p.S1166C|ARHGEF12_uc009zau.1_Missense_Mutation_p.S1082C	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1185					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		GGATTAGAATCTACCTTAATA	0.383			T	MLL	AML								8	42					0	0	0	0	G	120348886	G	G	120348886	3	3	235	1	0	0	0	0	1	0	0	0	897	913	32	2	3700	2	ARHGEF12	11	120348886	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	62550043	120348886	14657630	34	42586											
GLS2	27165	broad.mit.edu	37	chr12	56866515	56866515	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccactataggcagcaaataaCaggttgaccacagtcttgtt	13	10	8	10	0	1	1	0	1	1	0	1	1	1	1	2	2	2	4	2	2	4	6			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr12:56866515C>G	uc001slj.2	-	15	1749	c.1470G>C	c.(1468-1470)CTG>CTC	p.L490L	GLS2_uc009zos.2_RNA|GLS2_uc001slk.2_Silent_p.L225L|GLS2_uc009zot.2_Silent_p.L151L	NM_013267	NP_037399	Q9UI32	GLSL_HUMAN	glutaminase 2 precursor	490					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			ovary(1)|central_nervous_system(1)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CAGCAAATAACAGGTTGACCA	0.438													3	84					0	0	0	0	G	56866515	G	G	56866515	2	3	235	1	0	0	0	0	0	0	0	1	6501	465	17	4		4	GLS2	12	56866515	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08		56866515	76985380	35	42587											
TPH2	121278	broad.mit.edu	37	chr12	72335511	72335511	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaaagcactgaggctctttCaggtgaatgtgaaatatcat	14	12	9	6	0	3	3	2	3	1	0	3	3	3	3	0	2	1	2	0	2	5	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr12:72335511C>G	uc009zrw.1	+	2	394	c.253C>G	c.(253-255)CAG>GAG	p.Q85E	TPH2_uc001swy.2_5'UTR	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	85	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	GAGGCTCTTTCAGGTGAATGT	0.398													13	76					0	0	0	0	G	72335511	G	G	72335511	3	3	235	1	0	0	0	0	1	0	0	0	16469	827	29	2	259	2	TPH2	12	72335511	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	15468996	72335511	61516384	36	42588											
EEA1	8411	broad.mit.edu	37	chr12	93205154	93205158	+	Frame_Shift_Del	DEL	CTTGT	-	-																															agctgactgcaatgttcttgCttgtcttgtaactttgcagt																										TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr12:93205154_93205158delCTTGT	uc001tck.2	-	17	2361_2365	c.2096_2100delACAAG	c.(2095-2100)GACAAGfs	p.D699fs		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	699_700	Gln/Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						AATGTTCTTGCTTGTCTTGTAACTT	0.337													---	---	---								-	93205158	-	-	93205154	7	5	235	1	0	1	0	1	0	0	0	0	4943	796	28	0	2187	0	EEA1	12	93205154	Frame_Shift_Del	DEL	CTTGT	TCGA-CV-7243-01A-11D-2012-08	20869643	93205154	40646741	37	42589											
APPL2	55198	broad.mit.edu	37	chr12	105589401	105589401	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctctcagcctggaggattaTtcccctgaaacaaaagtgtc	11	10	9	11	0	1	1	1	1	1	0	4	3	2	3	3	2	2	1	3	2	4	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr12:105589401T>C	uc001tlf.1	-	12	1275	c.1057A>G	c.(1057-1059)ATA>GTA	p.I353V	APPL2_uc010swt.1_Missense_Mutation_p.I310V|APPL2_uc001tlg.1_Missense_Mutation_p.I107V|APPL2_uc010swu.1_Missense_Mutation_p.I359V|APPL2_uc009zuq.2_Missense_Mutation_p.I310V	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	353	Required for RAB5A binding (By similarity).|PH.				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						TGGAGGATTATTCCCCTGAAA	0.408													15	59					0	0	0	0	C	105589401	C	C	105589401	3	2	235	1	0	0	0	0	1	0	0	0	818	1493	52	5	977	5	APPL2	12	105589401	Missense_Mutation	SNP	T	TCGA-CV-7243-01A-11D-2012-08	12384247	105589401	28262494	38	42590											
TRPV4	59341	broad.mit.edu	37	chr12	110236702	110236702	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggttggtgcaggcagccagcGacaggggcagctcccctgcg	6	5	17	13	2	0	0	0	0	0	0	1	1	1	0	3	5	5	5	3	5	0	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr12:110236702G>A	uc001tpj.1	-	5	964	c.869C>T	c.(868-870)TCG>TTG	p.S290L	TRPV4_uc001tpg.1_Missense_Mutation_p.S256L|TRPV4_uc001tph.1_Missense_Mutation_p.S243L|TRPV4_uc001tpi.1_Missense_Mutation_p.S243L|TRPV4_uc001tpk.1_Missense_Mutation_p.S290L|TRPV4_uc001tpl.1_Missense_Mutation_p.S290L	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	290	Cytoplasmic (Potential).|ANK 2.				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GGCAGCCAGCGACAGGGGCAG	0.677													13	58					0	0	0	0	A	110236702	A	A	110236702	3	1	235	1	0	0	0	0	1	0	0	0	16665	1059	37	1	1790	1	TRPV4	12	110236702	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	4647301	110236702	23615193	39	42591											
GCN1L1	10985	broad.mit.edu	37	chr12	120582810	120582810	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagcaagtcctcaaagcacGactcccccatgcccttcacc	10	6	6	19	1	2	0	2	0	0	0	4	1	4	0	5	0	3	3	5	0	2	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr12:120582810G>A	uc001txo.2	-	40	5085	c.5072C>T	c.(5071-5073)TCG>TTG	p.S1691L		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1691					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCAAAGCACGACTCCCCCAT	0.592													10	91					0	0	0	0	A	120582810	A	A	120582810	3	1	235	1	0	0	0	0	1	0	0	0	6334	1059	37	1	3019	1	GCN1L1	12	120582810	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	10346108	120582810	13269085	40	42592											
RSRC2	65117	broad.mit.edu	37	chr12	123001845	123001845	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gatcttgagcgggaacgagaCctgatccgccgttttctttc	7	12	11	11	4	2	3	0	2	2	1	4	6	3	4	3	1	2	1	3	1	1	4			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr12:123001845C>A	uc001ucr.2	-	5	677	c.531G>T	c.(529-531)AGG>AGT	p.R177S	RSRC2_uc001uco.2_5'UTR|RSRC2_uc001ucp.2_Missense_Mutation_p.R118S|RSRC2_uc001ucq.2_5'UTR|RSRC2_uc001ucs.2_5'UTR|RSRC2_uc001uct.2_Missense_Mutation_p.R129S|RSRC2_uc001ucu.2_Missense_Mutation_p.R177S	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	177	Ser-rich.									ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		GGGAACGAGACCTGATCCGCC	0.493													23	123					3.5997e-14	3.5472e-13	1	0	A	123001845	A	A	123001845	3	1	235	1	0	0	0	0	1	0	0	0	13780	506	18	4	797	4	RSRC2	12	123001845	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	2419035	123001845	10850050	41	42593											
TM9SF2	9375	broad.mit.edu	37	chr13	100206567	100206570	+	Frame_Shift_Del	DEL	CACC	-	-																															ttttactgaaggccattgaaCacccagttcgaaccaatcag																										TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr13:100206567_100206570delCACC	uc001voj.1	+	14	1631_1634	c.1498_1501delCACC	c.(1498-1503)CACCCAfs	p.H500fs	TM9SF2_uc010afz.1_Frame_Shift_Del_p.H335fs	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	500_501	Cytoplasmic (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					GGCCATTGAACACCCAGTTCGAAC	0.417													---	---	---								-	100206570	-	-	100206567	7	5	235	1	0	1	0	1	0	0	0	0	16044	478	17	0	1552	0	TM9SF2	13	100206567	Frame_Shift_Del	DEL	CACC	TCGA-CV-7243-01A-11D-2012-08		100206567	14963311	42	42594											
OR4M1	441670	broad.mit.edu	37	chr14	20248681	20248681	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttcctgttggctaatctggCcctccttgatatttggtact	5	18	8	10	0	1	1	0	1	1	0	3	1	3	1	3	3	1	3	3	3	3	7			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr14:20248681C>T	uc010tku.1	+	1	200	c.200C>T	c.(199-201)GCC>GTC	p.A67V		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCTAATCTGGCCCTCCTTGAT	0.418													9	718					0	0	0	0	T	20248681	T	T	20248681	3	4	235	1	0	0	0	0	1	0	0	0	11129	739	26	4	202	4	OR4M1	14	20248681	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08		20248681	87100859	43	42595											
HOMEZ	57594	broad.mit.edu	37	chr14	23746122	23746122	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ataccacagcggaggcgctgGgccataaaccaagtcttgac	12	6	11	12	2	1	1	0	1	1	0	1	2	1	2	3	3	3	1	3	3	4	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr14:23746122G>A	uc001wja.2	-	2	463	c.315C>T	c.(313-315)GCC>GCT	p.A105A	HOMEZ_uc001wjb.2_Silent_p.A107A	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	105	Homeobox 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GGAGGCGCTGGGCCATAAACC	0.502													33	201					0	0	0	0	A	23746122	A	A	23746122	2	1	235	1	0	0	0	0	0	0	0	1	7320	1219	43	4		4	HOMEZ	14	23746122	Silent	SNP	G	TCGA-CV-7243-01A-11D-2012-08	3497441	23746122	83603418	44	42596											
MUDENG	55745	broad.mit.edu	37	chr14	57747048	57747048	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgacttctagtagtattGatgcaatggatgactctgca	10	15	9	7	0	3	3	0	3	3	0	3	4	3	4	0	1	2	4	0	1	4	6			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr14:57747048G>A	uc001xcv.2	+	3	1283	c.856G>A	c.(856-858)GAT>AAT	p.D286N	MUDENG_uc010tri.1_Missense_Mutation_p.D40N|MUDENG_uc010trj.1_Missense_Mutation_p.D183N	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	286	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1						TAGTAGTATTGATGCAATGGA	0.423													56	127					0	0	0	0	A	57747048	A	A	57747048	3	1	235	1	0	0	0	0	1	0	0	0	10036	1290	45	2	866	2	MUDENG	14	57747048	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	34000926	57747048	49602492	45	42597											
KIAA0586	9786	broad.mit.edu	37	chr14	58917303	58917303	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttctgttaaagcaccttTaaaagaagttgaagatacga	16	13	7	5	1	1	3	0	1	1	2	1	4	1	3	1	0	2	3	1	0	7	7			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr14:58917303T>C	uc001xdv.3	+	8	1241	c.968T>C	c.(967-969)TTA>TCA	p.L323S	KIAA0586_uc010trr.1_Missense_Mutation_p.L364S|KIAA0586_uc001xdt.3_Missense_Mutation_p.L279S|KIAA0586_uc001xdu.3_Missense_Mutation_p.L308S|KIAA0586_uc010trs.1_Missense_Mutation_p.L238S|KIAA0586_uc010trt.1_Missense_Mutation_p.L183S|KIAA0586_uc010tru.1_Missense_Mutation_p.L183S	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	323										ovary(1)	1						AAAGCACCTTTAAAAGAAGTT	0.308													11	38					0	0	0	0	C	58917303	C	C	58917303	3	2	235	1	0	0	0	0	1	0	0	0	8225	1764	61	5	998	5	KIAA0586	14	58917303	Missense_Mutation	SNP	T	TCGA-CV-7243-01A-11D-2012-08	1170255	58917303	48432237	46	42598											
C14orf49	161176	broad.mit.edu	37	chr14	95921755	95921755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caccagctcgtcctcggtccCcgctttcgccgcaggctgca	4	8	10	19	5	0	0	0	0	0	0	5	0	2	0	5	2	2	5	5	2	0	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr14:95921755C>T	uc001yei.3	-	5	1111	c.1096G>A	c.(1096-1098)GGG>AGG	p.G366R	C14orf49_uc010avi.2_Missense_Mutation_p.G366R|C14orf49_uc001yej.1_Missense_Mutation_p.G366R	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	366	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		TCCTCGGTCCCCGCTTTCGCC	0.652													17	55					0	0	0	0	T	95921755	T	T	95921755	3	4	235	1	0	0	0	0	1	0	0	0	1782	623	22	4	1883	4	C14orf49	14	95921755	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	37004452	95921755	11427785	47	42599											
MAP1A	4130	broad.mit.edu	37	chr15	43820775	43820775	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccaactgaaaccagccctaaCcccccaggccctgccccagc	10	3	6	22	0	0	1	0	1	0	0	0	1	0	1	9	1	6	0	9	1	3	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr15:43820775C>T	uc001zrt.2	+	4	7571	c.7104C>T	c.(7102-7104)AAC>AAT	p.N2368N		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2368						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCAGCCCTAACCCCCCAGGCC	0.642													7	29					0	0	0	0	T	43820775	T	T	43820775	2	4	235	1	0	0	0	0	0	0	0	1	9280	506	18	4		4	MAP1A	15	43820775	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08		43820775	58710617	48	42600											
TEX9	374618	broad.mit.edu	37	chr15	56719929	56719929	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aattaattgatgttttaaaaAggcaaaaggtgagtctatca	17	13	8	3	0	2	2	1	2	1	0	2	2	2	2	0	2	0	2	0	2	8	5			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr15:56719929A>G	uc002adp.2	+	11	1095	c.1090A>G	c.(1090-1092)AGG>GGG	p.R364G	TEX9_uc010ugl.1_Missense_Mutation_p.R289G	NM_198524	NP_940926	Q8N6V9	TEX9_HUMAN	testis expressed 9	364											0				all cancers(107;0.0394)|GBM - Glioblastoma multiforme(80;0.056)		TGTTTTAAAAAGGCAAAAGGT	0.244													3	165					0	0	0	0	G	56719929	G	G	56719929	3	3	235	1	0	0	0	0	1	0	0	0	15850	63	3	5	1132	5	TEX9	15	56719929	Missense_Mutation	SNP	A	TCGA-CV-7243-01A-11D-2012-08	12899154	56719929	45811463	49	42601											
PKD1	5310	broad.mit.edu	37	chr16	2158447	2158447	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctggatgctctgtgtcaGtggcgtgtccccaaatgaca	7	10	13	11	1	2	1	1	1	1	0	3	2	3	2	3	3	1	1	3	3	1	0			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr16:2158447G>C	uc002cos.1	-	15	6930	c.6721C>G	c.(6721-6723)CTG>GTG	p.L2241V	PKD1_uc002cot.1_Missense_Mutation_p.L2241V	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2241	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CTCTGTGTCAGTGGCGTGTCC	0.652													13	61					0	0	0	0	C	2158447	C	C	2158447	3	2	235	1	0	0	0	0	1	0	0	0	12018	1020	36	4	6318	4	PKD1	16	2158447	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08		2158447	88196306	50	42602											
MMP15	4324	broad.mit.edu	37	chr16	58074525	58074525	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaccccaatgccatcatggCgccgttctaccagtggaagg	10	7	10	14	2	2	0	1	0	1	0	2	1	2	1	5	3	3	1	5	3	4	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr16:58074525C>T	uc002ena.2	+	5	1806	c.833C>T	c.(832-834)GCG>GTG	p.A278V		NM_002428	NP_002419	P51511	MMP15_HUMAN	matrix metalloproteinase 15 preproprotein	278	Extracellular (Potential).				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			central_nervous_system(2)|breast(1)	3						GCCATCATGGCGCCGTTCTAC	0.612													33	72					0	0	0	0	T	58074525	T	T	58074525	3	4	235	1	0	0	0	0	1	0	0	0	9707	768	27	1	851	1	MMP15	16	58074525	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	55916078	58074525	32280228	51	42603											
SF3B3	23450	broad.mit.edu	37	chr16	70597896	70597896	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccttattatcattgaaacGgaccacaatgcctacactga	15	10	5	11	1	1	2	1	2	0	0	1	3	1	3	3	1	4	0	3	1	6	4			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr16:70597896G>A	uc002ezf.2	+	18	2617	c.2406G>A	c.(2404-2406)ACG>ACA	p.T802T		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	802					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				TCATTGAAACGGACCACAATG	0.463													14	89					0	0	0	0	A	70597896	A	A	70597896	2	1	235	1	0	0	0	0	0	0	0	1	14217	1103	39	1		1	SF3B3	16	70597896	Silent	SNP	G	TCGA-CV-7243-01A-11D-2012-08	12523371	70597896	19756857	52	42604											
MTSS1L	92154	broad.mit.edu	37	chr16	70698642	70698642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccatggccaggtcactggCggcgggggacacctcctcac	7	5	13	16	2	2	0	2	0	0	0	3	1	3	1	4	6	0	0	4	6	0	0	rs149700961		TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr16:70698642C>T	uc002ezj.2	-	14	1590	c.1330G>A	c.(1330-1332)GCC>ACC	p.A444T		NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	444					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						AGGTCACTGGCGGCGGGGGAC	0.672													7	19					0	0	0	0	T	70698642	T	T	70698642	3	4	235	1	0	0	0	0	1	0	0	0	10016	768	27	1	921	1	MTSS1L	16	70698642	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	100746	70698642	19656111	53	42605											
KCNG4	93107	broad.mit.edu	37	chr16	84270386	84270386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctgacacacaggctgaCggctgtggtggccacgaaga	9	6	16	10	2	0	3	0	2	0	1	0	4	0	3	1	5	1	3	1	5	1	0	rs138891680	byFrequency	TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr16:84270386C>T	uc010voc.1	-	2	827	c.706G>A	c.(706-708)GTC>ATC	p.V236I	KCNG4_uc002fhu.1_Missense_Mutation_p.V236I	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	236						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						CACAGGCTGACGGCTGTGGTG	0.602													19	21					0	0	0	0	T	84270386	T	T	84270386	3	4	235	1	0	0	0	0	1	0	0	0	8069	536	19	1	859	1	KCNG4	16	84270386	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	13571744	84270386	6084367	54	42606											
TP53	7157	broad.mit.edu	37	chr17	7578446	7578466	+	In_Frame_Del	DEL	TGGCCATGGCGCGGACGCGGG	-	-																															gtgctgtgactgcttgtagaTggccatggcgcggacgcggg																								rs139200646		TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr17:7578446_7578466delTGGCCATGGCGCGGACGCGGG	uc002gim.2	-	5	658_678	c.464_484delCCCGCGTCCGCGCCATGGCCA	c.(463-486)ACCCGCGTCCGCGCCATGGCCATC>ATC	p.TRVRAMA155del	TP53_uc002gig.1_In_Frame_Del_p.TRVRAMA155del|TP53_uc002gih.2_In_Frame_Del_p.TRVRAMA155del|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.TRVRAMA23del|TP53_uc010cng.1_In_Frame_Del_p.TRVRAMA23del|TP53_uc002gii.1_In_Frame_Del_p.TRVRAMA23del|TP53_uc010cnh.1_In_Frame_Del_p.TRVRAMA155del|TP53_uc010cni.1_In_Frame_Del_p.TRVRAMA155del|TP53_uc002gij.2_In_Frame_Del_p.TRVRAMA155del|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_In_Frame_Del_p.TRVRAMA62del|TP53_uc002gio.2_In_Frame_Del_p.TRVRAMA23del|TP53_uc010vug.1_In_Frame_Del_p.TRVRAMA116del	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	155_161	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		MA -> IP (in a sporadic cancer; somatic mutation).|MA -> IS (in sporadic cancers; somatic mutation).|MA -> IT (in a sporadic cancer; somatic mutation).|A -> G (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V157F(139)|p.R158H(58)|p.R158L(55)|p.A161T(44)|p.A159V(30)|p.R156P(24)|p.T155N(19)|p.R158C(17)|p.T155P(14)|p.A159P(13)|p.V157I(10)|p.R156H(10)|p.T155I(10)|p.R158G(10)|p.R158P(9)|p.I162F(8)|p.V157D(8)|p.A159A(8)|p.A161D(8)|p.R156fs*14(8)|p.V157G(7)|p.A159T(7)|p.A159D(7)|p.A161V(7)|p.T155A(7)|p.0?(7)|p.V157L(6)|p.M160I(6)|p.R158R(6)|p.V157V(5)|p.A159fs*11(5)|p.I162V(5)|p.R158fs*12(5)|p.A161A(5)|p.T155T(5)|p.A159S(4)|p.R158_A159insX(4)|p.M160K(4)|p.M160V(4)|p.R156S(3)|p.R156R(3)|p.R156fs*25(3)|p.R156G(3)|p.M160fs*10(3)|p.A161fs*9(3)|p.R156L(3)|p.M160L(3)|p.P152fs*14(3)|p.V157fs*13(3)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.R158fs*11(2)|p.R156C(2)|p.G154fs*14(2)|p.R156_I162delRVRAMAI(2)|p.A159fs*21(2)|p.V157fs*22(2)|p.V157fs*24(2)|p.R158_A159delRA(2)|p.I162fs*19(2)|p.P153fs*22(2)|p.T155S(2)|p.V157A(1)|p.G154_R156delGTR(1)|p.T155fs*25(1)|p.M160_A161>IS(1)|p.V157_R158delVR(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.A161S(1)|p.A161P(1)|p.A161F(1)|p.A161G(1)|p.V157_C176del20(1)|p.A161fs*19(1)|p.R156_A161delRVRAMA(1)|p.M160T(1)|p.R156del(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.D148_T155delDSTPPPGT(1)|p.A161fs*20(1)|p.A161fs*8(1)|p.S149fs*72(1)|p.V157_M160delVRAM(1)|p.A161fs*7(1)|p.T155fs*15(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.V157fs*25(1)|p.R158fs*24(1)|p.T155fs*26(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.A161fs*10(1)|p.I162_Y163delIY(1)|p.T155_R156delTR(1)|p.A159_Q167delAMAIYKQSQ(1)|p.R158fs*8(1)|p.P151_V173del23(1)|p.I162fs*8(1)|p.R156_A161del(1)|p.D148fs*23(1)|p.R158F(1)|p.R158_A159insXX(1)|p.G154fs*22(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTGTAGATGGCCATGGCGCGGACGCGGGTGCCGGGCGG	0.62		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578466	-	-	7578446	7	5	235	1	0	1	0	1	0	0	0	0	16448	1464	51	0	814	0	TP53	17	7578446	In_Frame_Del	DEL	TGGCCATGGCGCGGACGCGGG	TCGA-CV-7243-01A-11D-2012-08		7578446	73616764	55	42607											
KCNJ12	3768	broad.mit.edu	37	chr17	21318845	21318845	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgccaacatggacgagaagtCacagcgctacctggctgaca	12	5	11	13	3	1	2	1	1	0	1	1	4	1	3	2	2	3	2	2	2	3	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr17:21318845C>T	uc002gyv.1	+	3	896	c.191C>T	c.(190-192)TCA>TTA	p.S64L		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	64	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	GACGAGAAGTCACAGCGCTAC	0.592										Prostate(3;0.18)			5	66					0	0	0	0	T	21318845	T	T	21318845	3	4	235	1	0	0	0	0	1	0	0	0	8085	838	29	2	193	2	KCNJ12	17	21318845	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	13740399	21318845	59876365	56	42608											
DDX52	11056	broad.mit.edu	37	chr17	35981216	35981216	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agctagttggaaagtcatagTtgatcaccaagttcacacct	13	11	8	9	0	3	1	3	1	0	0	3	2	3	2	2	1	1	4	2	1	4	5			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr17:35981216T>C	uc002hoi.1	-	11	1495	c.1457A>G	c.(1456-1458)AAC>AGC	p.N486S	DDX52_uc002hoh.1_Missense_Mutation_p.N378S	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a	486	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				AAAGTCATAGTTGATCACCAA	0.433													17	26					0	0	0	0	C	35981216	C	C	35981216	3	2	235	1	0	0	0	0	1	0	0	0	4387	1725	60	5	362	5	DDX52	17	35981216	Missense_Mutation	SNP	T	TCGA-CV-7243-01A-11D-2012-08	14662371	35981216	45213994	57	42609											
CNTNAP1	8506	broad.mit.edu	37	chr17	40847683	40847683	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catcccgggctatgatactcCgggctatgtgcctggctacc	6	10	11	14	2	0	1	0	1	0	0	2	1	2	1	4	3	3	3	4	3	4	4			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr17:40847683C>T	uc002iay.2	+	19	3353	c.3137C>T	c.(3136-3138)CCG>CTG	p.P1046L	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	1046	Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		TATGATACTCCGGGCTATGTG	0.657													15	56					0	0	0	0	T	40847683	T	T	40847683	3	4	235	1	0	0	0	0	1	0	0	0	3661	652	23	1	3211	1	CNTNAP1	17	40847683	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	4866467	40847683	40347527	58	42610											
C17orf71	55181	broad.mit.edu	37	chr17	57287434	57287434	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggctggtcccgtgagcttgCgagaccttctaatgggagca	7	10	14	10	2	1	2	0	1	1	1	2	4	2	3	2	3	3	3	2	3	1	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr17:57287434C>T	uc002ixi.2	+	1	64	c.22C>T	c.(22-24)CGA>TGA	p.R8*		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	8					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					CGTGAGCTTGCGAGACCTTCT	0.597													9	13					0	0	0	0	T	57287434	T	T	57287434	4	4	235	1	0	0	0	0	0	1	0	0	1885	760	27	1	24	1	C17orf71	17	57287434	Nonsense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	16439751	57287434	23907776	59	42611											
RPTOR	57521	broad.mit.edu	37	chr17	78516455	78516456	+	5'Flank	INS	-	A	A																															aataaaactgtaaaaactgcINSaaaaaaaaaaaaatgcagat																								rs112348092		TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr17:78516455_78516456insA	uc002jyt.1	+						RPTOR_uc002jys.2_5'Flank|RPTOR_uc010wuf.1_5'Flank|RPTOR_uc010wug.1_5'Flank|RPTOR_uc002jyr.1_5'Flank	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1						cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						GTAAAAACTGCAAAAAAAaaaa	0.228													---	---	---								A	78516456	A	A	78516455	6	5	235	0	1	1	1	0	0	0	0	0	13730	725	25	0		0	RPTOR	17	78516455	5'Flank	INS	-	TCGA-CV-7243-01A-11D-2012-08	21229021	78516455	2678755	60	42612											
PTPRM	5797	broad.mit.edu	37	chr18	8379226	8379226	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcatcgcactgttgccccGgaaccatgagaaaaaccggt	12	6	10	13	3	0	1	0	1	0	1	1	3	0	2	4	2	4	3	4	2	3	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr18:8379226G>A	uc002knn.3	+	26	4138	c.3635G>A	c.(3634-3636)CGG>CAG	p.R1212Q	PTPRM_uc010dkv.2_Missense_Mutation_p.R1225Q|PTPRM_uc010wzl.1_Missense_Mutation_p.R999Q	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1212	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CTGTTGCCCCGGAACCATGAG	0.547													18	102					0	0	0	0	A	8379226	A	A	8379226	3	1	235	1	0	0	0	0	1	0	0	0	12871	1116	39	1	3784	1	PTPRM	18	8379226	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08		8379226	69698022	61	42613											
KIAA1632	57724	broad.mit.edu	37	chr18	43467768	43467768	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgccttgttgggggatgaCgctgcgtctcatcgctgacg	5	11	14	11	4	1	2	1	2	1	0	3	3	1	3	1	2	2	3	1	2	0	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr18:43467768C>T	uc002lbm.2	-	29	5157	c.5057G>A	c.(5056-5058)CGT>CAT	p.R1686H	KIAA1632_uc010xcq.1_Missense_Mutation_p.R240H|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.R561H	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1686					autophagy						0						TGGGGGATGACGCTGCGTCTC	0.448													16	79					0	0	0	0	T	43467768	T	T	43467768	3	4	235	1	0	0	0	0	1	0	0	0	8288	536	19	1	2746	1	KIAA1632	18	43467768	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	35088542	43467768	34609480	62	42614											
ELAC1	55520	broad.mit.edu	37	chr18	48500811	48500811	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cattcctggggacgggtgcaGcatacccatctccaacccgg	8	7	11	15	2	1	0	0	0	1	0	3	1	2	1	4	4	4	2	4	4	2	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr18:48500811G>A	uc002lez.2	+	2	143	c.37G>A	c.(37-39)GCA>ACA	p.A13T	ELAC1_uc010dpe.2_Missense_Mutation_p.A13T|SMAD4_uc010xdo.1_RNA	NM_018696	NP_061166	Q9H777	RNZ1_HUMAN	elaC homolog 1	13					tRNA 3'-trailer cleavage	nucleus	endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0		Colorectal(6;0.0269)|all_epithelial(6;0.0729)		Colorectal(21;0.000943)|COAD - Colon adenocarcinoma(17;0.0398)|READ - Rectum adenocarcinoma(32;0.0894)|STAD - Stomach adenocarcinoma(97;0.18)		GACGGGTGCAGCATACCCATC	0.507													9	50					0	0	0	0	A	48500811	A	A	48500811	3	1	235	1	0	0	0	0	1	0	0	0	5070	971	34	4	39	4	ELAC1	18	48500811	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	5033043	48500811	29576437	63	42615											
ATP5D	513	broad.mit.edu	37	chr19	1244103	1244103	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccattcccccagtgagcagCggttccatcgcagtgaacgc	8	7	10	16	3	0	2	0	2	0	0	3	2	2	2	4	1	3	3	4	1	1	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:1244103C>T	uc002lrn.2	+	3	404	c.303C>T	c.(301-303)AGC>AGT	p.S101S	ATP5D_uc002lro.2_Silent_p.S101S	NM_001001975	NP_001001975	P30049	ATPD_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	101					mitochondrial ATP synthesis coupled proton transport|oxidative phosphorylation|respiratory electron transport chain|response to copper ion	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CAGTGAGCAGCGGTTCCATCG	0.647											OREG0025113	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	5					0	0	0	0	T	1244103	T	T	1244103	2	4	235	1	0	0	0	0	0	0	0	1	1152	767	27	1		1	ATP5D	19	1244103	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08		1244103	57884880	64	42616											
PLEKHJ1	55111	broad.mit.edu	37	chr19	2234193	2234193	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cactcctgacactgctcctcGctgctgcactcaaagtgata	9	10	7	15	1	1	2	1	2	0	0	4	2	3	2	2	0	3	4	2	0	2	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:2234193G>A	uc002lvf.1	-	4	357	c.276C>T	c.(274-276)AGC>AGT	p.S92S	MIR1227_hsa-mir-1227|MI0006316_5'Flank|SF3A2_uc002lvg.2_5'Flank	NM_018049	NP_060519	Q9NW61	PKHJ1_HUMAN	pleckstrin homology domain containing, family J	92	PH.						protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTGCTCCTCGCTGCTGCACT	0.632													13	60					0	0	0	0	A	2234193	A	A	2234193	2	1	235	1	0	0	0	0	0	0	0	1	12134	1078	38	1		1	PLEKHJ1	19	2234193	Silent	SNP	G	TCGA-CV-7243-01A-11D-2012-08	990090	2234193	56894790	65	42617											
MUC16	94025	broad.mit.edu	37	chr19	9088852	9088852	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcagagagagaagtggcaGaggttgaaacagtggttgtt	13	9	16	3	0	0	4	0	1	0	3	0	6	0	4	0	3	2	5	0	3	3	4			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:9088852G>T	uc002mkp.2	-	1	3167	c.2963C>A	c.(2962-2964)TCT>TAT	p.S988Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	988	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGAAGTGGCAGAGGTTGAAAC	0.463													55	241					1.19403e-26	1.18901e-25	1	0	T	9088852	T	T	9088852	3	4	235	1	0	0	0	0	1	0	0	0	10026	942	33	2	40896	2	MUC16	19	9088852	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	6854659	9088852	50040131	66	42618											
CACNA1A	773	broad.mit.edu	37	chr19	13395974	13395974	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttcctcctcctccttcttCtcttcctctttttttggcag	1	21	3	16	0	4	0	0	0	4	0	10	0	9	0	5	1	0	1	5	1	0	7			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:13395974C>T	uc010dze.2	-	21	3839	c.3603G>A	c.(3601-3603)GAG>GAA	p.E1201E	CACNA1A_uc010dzc.2_Silent_p.E726E|CACNA1A_uc002mwy.3_Silent_p.E1200E|CACNA1A_uc010xne.1_Silent_p.E729E	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1201	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	cctccttcttctcttcctctt	0.443													28	43					0	0	0	0	T	13395974	T	T	13395974	2	4	235	1	0	0	0	0	0	0	0	1	2550	912	32	2		2	CACNA1A	19	13395974	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08	4307122	13395974	45733009	67	42619											
TMEM59L	25789	broad.mit.edu	37	chr19	18729231	18729231	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcctgctgcctcttcctcTccgtgctggtgatgctgtgg	1	14	13	13	1	2	1	0	1	2	0	4	1	3	1	4	3	4	3	4	3	0	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:18729231T>C	uc002njy.3	+	7	916	c.829T>C	c.(829-831)TCC>CCC	p.S277P		NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	277	Helical; (Potential).					Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						CCTCTTCCTCTCCGTGCTGGT	0.697													3	26					0	0	0	0	C	18729231	C	C	18729231	3	2	235	1	0	0	0	0	1	0	0	0	16252	1551	54	5	855	5	TMEM59L	19	18729231	Missense_Mutation	SNP	T	TCGA-CV-7243-01A-11D-2012-08	5333257	18729231	40399752	68	42620											
RYR1	6261	broad.mit.edu	37	chr19	38980889	38980889	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagactgcaagacgtacccgCgagttccgctccccacccca	9	5	9	18	4	0	2	0	0	0	2	2	4	2	2	6	0	2	4	6	0	2	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:38980889C>T	uc002oit.2	+	36	6118	c.5988C>T	c.(5986-5988)CGC>CGT	p.R1996R	RYR1_uc002oiu.2_Silent_p.R1996R	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1996	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GACGTACCCGCGAGTTCCGCT	0.572													14	29					0	0	0	0	T	38980889	T	T	38980889	2	4	235	1	0	0	0	0	0	0	0	1	13833	755	27	1		1	RYR1	19	38980889	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08	20251658	38980889	20148094	69	42621											
PSG8	440533	broad.mit.edu	37	chr19	43258661	43258661	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgccggtgggttagagtccGcagaacaggacaagtagagg	11	6	17	7	2	0	3	0	0	0	3	1	4	1	4	2	4	2	3	2	4	4	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:43258661G>A	uc002ouo.2	-	5	1165	c.1067C>T	c.(1066-1068)GCG>GTG	p.A356V	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Missense_Mutation_p.A195V|PSG8_uc002ouh.2_Missense_Mutation_p.A356V|PSG8_uc010ein.2_Missense_Mutation_p.A234V|PSG8_uc002ouj.3_Missense_Mutation_p.A138V|PSG8_uc002ouk.3_Missense_Mutation_p.A195V|PSG8_uc002oul.3_Missense_Mutation_p.A356V|PSG8_uc002oum.3_Missense_Mutation_p.A263V|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.A263V	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	356	Ig-like C2-type 3.					extracellular region					0		Prostate(69;0.00899)				GTTAGAGTCCGCAGAACAGGA	0.453													53	237					0	0	0	0	A	43258661	A	A	43258661	3	1	235	1	0	0	0	0	1	0	0	0	12723	1087	38	1	238	1	PSG8	19	43258661	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	4277772	43258661	15870322	70	42622											
GLTSCR1	29998	broad.mit.edu	37	chr19	48183863	48183863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctactgcctggcgccccggCggtccagctcccgcagcagc	4	5	12	20	4	0	0	0	0	0	0	2	0	2	0	6	3	5	3	6	3	1	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:48183863C>T	uc002phh.3	+	6	1630	c.1436C>T	c.(1435-1437)GCG>GTG	p.A479V	GLTSCR1_uc002phi.3_Missense_Mutation_p.A237V	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	479							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		GGCGCCCCGGCGGTCCAGCTC	0.697													11	23					0	0	0	0	T	48183863	T	T	48183863	3	4	235	1	0	0	0	0	1	0	0	0	6511	768	27	1	1450	1	GLTSCR1	19	48183863	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	4925202	48183863	10945120	71	42623											
BAX	581	broad.mit.edu	37	chr19	49458947	49458947	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccatccccactctagtttCatccaggatcgagcagggcg	8	9	9	15	2	2	0	1	0	1	0	6	2	5	1	4	2	1	2	4	2	1	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:49458947C>T	uc002plk.2	+	3	159	c.90C>T	c.(88-90)TTC>TTT	p.F30F	BAX_uc002plf.1_Silent_p.F30F|BAX_uc002plg.1_5'UTR|BAX_uc002plh.1_Intron|BAX_uc010xzx.1_RNA|BAX_uc002plj.2_Silent_p.F30F|BAX_uc002pll.2_Intron|BAX_uc002plm.2_Intron	NM_138761	NP_620116	Q07812	BAX_HUMAN	BCL2-associated X protein isoform alpha	30					activation of caspase activity by cytochrome c|activation of pro-apoptotic gene products|B cell apoptosis|cleavage of lamin|DNA fragmentation involved in apoptotic nuclear change|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|induction of retinal programmed cell death|mitochondrial fragmentation involved in apoptosis|mitochondrial fusion|negative regulation of protein binding|negative regulation of survival gene product expression|nuclear fragmentation involved in apoptotic nuclear change|positive regulation of neuron apoptosis|protein homooligomerization|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria|release of matrix enzymes from mitochondria|response to toxin|transformed cell apoptosis	cytosol|endoplasmic reticulum membrane|mitochondrial outer membrane|mitochondrial permeability transition pore complex|nucleus	BH3 domain binding|channel activity|lipid binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000159)|all cancers(93;0.00047)|GBM - Glioblastoma multiforme(486;0.018)|Epithelial(262;0.0279)		ACTCTAGTTTCATCCAGGATC	0.582													11	75					0	0	0	0	T	49458947	T	T	49458947	2	4	235	1	0	0	0	0	0	0	0	1	1330	825	29	2		2	BAX	19	49458947	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08	1275084	49458947	9670036	72	42624											
ALDH16A1	126133	broad.mit.edu	37	chr19	49962338	49962338	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcgtccgggcccagcacctGaccaggtgatgcagctgagg	7	6	15	13	2	0	3	0	3	0	0	2	3	1	3	4	3	3	3	4	3	0	0			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:49962338G>A	uc002pnt.2	+	3	431	c.315G>A	c.(313-315)CTG>CTA	p.L105L	ALDH16A1_uc010yar.1_Silent_p.L105L|ALDH16A1_uc010yas.1_Intron|ALDH16A1_uc010yat.1_Intron	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	105							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CCCAGCACCTGACCAGGTGAT	0.642													14	94					0	0	0	0	A	49962338	A	A	49962338	2	1	235	1	0	0	0	0	0	0	0	1	488	1277	45	2		2	ALDH16A1	19	49962338	Silent	SNP	G	TCGA-CV-7243-01A-11D-2012-08	503391	49962338	9166645	73	42625											
PRR12	57479	broad.mit.edu	37	chr19	50100303	50100305	+	In_Frame_Del	DEL	CGG	-	-																															tggcgtaggcccaccaaactCggagggcaaggatcccgcag																										TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:50100303_50100305delCGG	uc002poo.3	+	4	2711_2713	c.2711_2713delCGG	c.(2710-2715)TCGGAG>TAG	p.904_905SE>*		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	83_84	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CCACCAAACTCGGAGGGCAAGGA	0.69													---	---	---								-	50100305	-	-	50100303	7	5	235	1	0	1	0	1	0	0	0	0	12646	893	31	0	2725	0	PRR12	19	50100303	In_Frame_Del	DEL	CGG	TCGA-CV-7243-01A-11D-2012-08	137965	50100303	9028680	74	42626											
ZNF610	162963	broad.mit.edu	37	chr19	52869877	52869877	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgggcgcaaattatacctaAccaaccatcagagaattcat	15	10	6	10	1	2	1	2	0	0	1	2	2	2	1	3	1	3	1	3	1	6	5			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:52869877A>T	uc002pyx.3	+	6	1652	c.1246A>T	c.(1246-1248)ACC>TCC	p.T416S	ZNF610_uc002pyy.3_Missense_Mutation_p.T416S|ZNF610_uc002pyz.3_Missense_Mutation_p.T373S|ZNF610_uc002pza.2_Missense_Mutation_p.T416S	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	416	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		ATTATACCTAACCAACCATCA	0.423													11	53					0	0	0	0	T	52869877	T	T	52869877	3	4	235	1	0	0	0	0	1	0	0	0	18103	43	2	5	1260	5	ZNF610	19	52869877	Missense_Mutation	SNP	A	TCGA-CV-7243-01A-11D-2012-08	2769574	52869877	6259106	75	42627											
CACNG7	59284	broad.mit.edu	37	chr19	54416119	54416119	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagccgcgccctgaccctgCtgagcagcgtgtttggtgcg	4	8	15	14	4	0	2	0	2	0	0	0	2	0	2	3	1	5	4	3	1	0	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:54416119C>T	uc002qcr.1	+	1	49	c.34C>T	c.(34-36)CTG>TTG	p.L12L	CACNG7_uc010era.1_Silent_p.L12L	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	12	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		CCTGACCCTGCTGAGCAGCGT	0.632													7	41					0	0	0	0	T	54416119	T	T	54416119	2	4	235	1	0	0	0	0	0	0	0	1	2574	796	28	4		4	CACNG7	19	54416119	Silent	SNP	C	TCGA-CV-7243-01A-11D-2012-08	1546242	54416119	4712864	76	42628											
NLRP11	204801	broad.mit.edu	37	chr19	56300195	56300195	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactaccttaagtacacaatCtgggctgatcaagctctcaa	14	10	6	11	0	3	1	2	1	2	0	4	1	3	1	1	1	4	3	1	1	7	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:56300195C>G	uc010ygf.1	-	11	3544	c.2833G>C	c.(2833-2835)GAT>CAT	p.D945H	NLRP11_uc002qlz.2_Missense_Mutation_p.D792H|NLRP11_uc002qmb.2_Missense_Mutation_p.D846H|NLRP11_uc002qmc.2_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	945							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		AGTACACAATCTGGGCTGATC	0.318													11	50					0	0	0	0	G	56300195	G	G	56300195	3	3	235	1	0	0	0	0	1	0	0	0	10527	913	32	2	276	2	NLRP11	19	56300195	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08	1884076	56300195	2828788	77	42629											
ZNF329	79673	broad.mit.edu	37	chr19	58639337	58639337	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttccacactgaggacaccGgctgggaccctccctgctat	7	10	9	15	1	0	1	0	1	0	0	2	3	2	3	4	3	1	2	4	3	1	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr19:58639337G>A	uc002qrn.2	-	4	1771	c.1534C>T	c.(1534-1536)CGG>TGG	p.R512W	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	512	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TGAGGACACCGGCTGGGACCC	0.507													63	106					0	0	0	0	A	58639337	A	A	58639337	3	1	235	1	0	0	0	0	1	0	0	0	17914	1115	39	1	95	1	ZNF329	19	58639337	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	2339142	58639337	489646	78	42630											
SIRPB1	10326	broad.mit.edu	37	chr20	1551696	1551696	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accaggtcagctgtagtcccCgggggtagaaattgctcacc	9	8	12	12	1	2	1	2	0	0	1	3	1	3	1	4	3	2	4	4	3	3	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr20:1551696C>T	uc010gai.2	-	4	938	c.839G>A	c.(838-840)CGG>CAG	p.R280Q	SIRPB1_uc002wfk.3_Intron	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	280	Ig-like C1-type 2.|Extracellular (Potential).				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						CTGTAGTCCCCGGGGGTAGAA	0.537													38	68					0	0	0	0	T	1551696	T	T	1551696	3	4	235	1	0	0	0	0	1	0	0	0	14398	652	23	1	365	1	SIRPB1	20	1551696	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08		1551696	61473824	79	42631											
PAX1	5075	broad.mit.edu	37	chr20	21687285	21687285	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccattctgcccggggccatcGgggggagcaagccccgcgtc	5	5	15	16	4	1	0	0	0	1	0	3	1	1	1	5	5	3	1	5	5	1	1			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr20:21687285G>A	uc002wsj.2	+	2	550	c.496G>A	c.(496-498)GGG>AGG	p.G166R	PAX1_uc010zsl.1_Missense_Mutation_p.G166R|PAX1_uc010zsm.1_Missense_Mutation_p.G142R	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	166	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						CGGGGCCATCGGGGGGAGCAA	0.647													18	89					0	0	0	0	A	21687285	A	A	21687285	3	1	235	1	0	0	0	0	1	0	0	0	11532	1116	39	1	502	1	PAX1	20	21687285	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	20135589	21687285	41338235	80	42632											
C20orf4	25980	broad.mit.edu	37	chr20	34827959	34827959	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatccctccaggcatccacTtcctccactacagctctgtg	7	11	6	17	0	1	1	0	1	1	0	6	1	6	1	5	1	2	2	5	1	1	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr20:34827959T>G	uc002xfc.1	+	2	262	c.169T>G	c.(169-171)TTC>GTC	p.F57V	C20orf4_uc002xfd.1_Missense_Mutation_p.F57V|C20orf4_uc002xfe.1_Missense_Mutation_p.F57V	NM_015511	NP_056326	Q9Y312	CT004_HUMAN	hypothetical protein LOC25980	57											0	Breast(12;0.0162)	Myeloproliferative disorder(115;0.0393)				AGGCATCCACTTCCTCCACTA	0.572													7	81					0	0	0	0	G	34827959	G	G	34827959	3	3	235	1	0	0	0	0	1	0	0	0	2121	1609	56	5	171	5	C20orf4	20	34827959	Missense_Mutation	SNP	T	TCGA-CV-7243-01A-11D-2012-08	13140674	34827959	28197561	81	42633											
NCAM2	4685	broad.mit.edu	37	chr21	22804480	22804480	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atagagctgtcgcagaccacGgccaaggtttccttcaacaa	12	8	9	12	2	1	2	1	0	0	2	3	2	2	2	3	2	2	3	3	2	4	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr21:22804480G>A	uc002yld.1	+	12	1782	c.1533G>A	c.(1531-1533)ACG>ACA	p.T511T	NCAM2_uc011acb.1_Silent_p.T369T	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	511	Fibronectin type-III 1.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CGCAGACCACGGCCAAGGTTT	0.448													6	48					0	0	0	0	A	22804480	A	A	22804480	2	1	235	1	0	0	0	0	0	0	0	1	10257	1103	39	1		1	NCAM2	21	22804480	Silent	SNP	G	TCGA-CV-7243-01A-11D-2012-08		22804480	25325415	82	42634											
HPS4	89781	broad.mit.edu	37	chr22	26849348	26849348	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggatggggttgcaacaggCgtacacagccgtggaggcat	9	7	16	9	2	0	0	0	0	0	0	0	2	0	2	1	6	4	4	1	6	2	2			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chr22:26849348C>T	uc003acl.2	-	14	2637	c.1978G>A	c.(1978-1980)GCC>ACC	p.A660T	HPS4_uc003aci.2_Missense_Mutation_p.A655T|HPS4_uc003acj.2_Missense_Mutation_p.A524T|HPS4_uc003ack.2_Missense_Mutation_p.A451T|HPS4_uc003acn.2_Missense_Mutation_p.A506T|HPS4_uc003ach.2_Missense_Mutation_p.A395T	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	660					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						TTGCAACAGGCGTACACAGCC	0.562									Hermansky-Pudlak_syndrome				16	105					0	0	0	0	T	26849348	T	T	26849348	3	4	235	1	0	0	0	0	1	0	0	0	7380	768	27	1	152	1	HPS4	22	26849348	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08		26849348	24455218	83	42635											
NOX1	27035	broad.mit.edu	37	chrX	100099014	100099014	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatatcggtgacagcatttgCgcaggctctttgccaaagtc	10	11	10	10	2	1	1	0	1	1	0	3	1	1	1	1	2	3	3	1	2	3	3			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chrX:100099014C>T	uc004egj.2	-	13	1828	c.1622G>A	c.(1621-1623)CGC>CAC	p.R541H	NOX1_uc004egl.3_Missense_Mutation_p.R492H|NOX1_uc010nne.2_Missense_Mutation_p.R504H	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	541	Cytoplasmic (Potential).				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						ACAGCATTTGCGCAGGCTCTT	0.428													5	18					0	0	0	0	T	100099014	T	T	100099014	3	4	235	1	0	0	0	0	1	0	0	0	10610	768	27	1	76	1	NOX1	23	100099014	Missense_Mutation	SNP	C	TCGA-CV-7243-01A-11D-2012-08		100099014	55171546	84	42636											
GPR112	139378	broad.mit.edu	37	chrX	135487937	135487937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgaatctctccatgttctGcactgttcttgttcaactga	8	16	6	11	0	4	2	1	2	3	0	6	2	5	2	1	0	2	4	1	0	2	4			TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chrX:135487937G>A	uc004ezu.1	+	23	9032	c.8741G>A	c.(8740-8742)TGC>TAC	p.C2914Y	GPR112_uc010nsb.1_Missense_Mutation_p.C2709Y	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2914	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TCCATGTTCTGCACTGTTCTT	0.398													24	65					0	0	0	0	A	135487937	A	A	135487937	3	1	235	1	0	0	0	0	1	0	0	0	6667	1319	46	4	8819	4	GPR112	23	135487937	Missense_Mutation	SNP	G	TCGA-CV-7243-01A-11D-2012-08	35388923	135487937	19782623	85	42637											
TKTL1	8277	broad.mit.edu	37	chrX	153524304	153524305	+	Frame_Shift_Ins	INS	-	GC	GC																															caagatatggccagccgcttINSgcgaatccattccatcaggg																										TCGA-CV-7243-01A-11D-2012-08	TCGA-CV-7243-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc6a2b7c-8a6c-4084-8551-8d1db9072ec2	b3d9813d-2810-4073-b4b8-5675f7105d87	g.chrX:153524304_153524305insGC	uc004fkg.2	+	1	278_279	c.92_93insGC	c.(91-93)TTGfs	p.L31fs	TEX28_uc004fke.2_5'Flank|TEX28_uc004fkf.2_5'Flank|TEX28_uc010nut.1_5'Flank|TKTL1_uc011mzl.1_Frame_Shift_Ins_p.L31fs|TKTL1_uc011mzm.1_Frame_Shift_Ins_p.L31fs	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	31					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCAGCCGCTTGCGAATCCATT	0.614													---	---	---								GC	153524305	GC	GC	153524304	7	5	235	1	0	1	1	0	0	0	0	0	16001	1821	63	0	94	0	TKTL1	23	153524304	Frame_Shift_Ins	INS	-	TCGA-CV-7243-01A-11D-2012-08	18036367	153524304	1746256	86	42638											
VPS13D	55187	broad.mit.edu	37	chr1	12418560	12418560	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attcatccagaaggcatgccGggctggtgtcagggcttctc	7	10	13	11	1	3	1	2	0	1	1	5	1	4	1	2	4	1	3	2	4	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:12418560G>T	uc001atv.2	+	50	10185	c.10044G>T	c.(10042-10044)CCG>CCT	p.P3348P	VPS13D_uc001atw.2_Silent_p.P3323P|VPS13D_uc001atx.2_Silent_p.P2535P	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3347					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AAGGCATGCCGGGCTGGTGTC	0.512													39	17					3.54909e-21	7.05507e-21	1	0	T	12418560	T	T	12418560	2	4	236	1	0	0	0	0	0	0	0	1	17260	1103	39	3		3	VPS13D	1	12418560	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08		12418560	236832061	1	42639											
KLHDC7A	127707	broad.mit.edu	37	chr1	18808770	18808770	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacaggtccgcctggatcTgggcaattgctatgaggtgc	7	9	13	12	1	1	1	0	1	1	0	2	2	2	2	3	4	2	2	3	4	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:18808770T>C	uc001bax.2	+	1	1347	c.1295T>C	c.(1294-1296)CTG>CCG	p.L432P	KLHDC7A_uc009vpg.2_Missense_Mutation_p.L214P	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	432						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CGCCTGGATCTGGGCAATTGC	0.612													72	40					0	0	0	0	C	18808770	C	C	18808770	3	2	236	1	0	0	0	0	1	0	0	0	8399	1580	55	5	1297	5	KLHDC7A	1	18808770	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	6390210	18808770	230441851	2	42640											
HSPG2	3339	broad.mit.edu	37	chr1	22179293	22179293	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgcctgagtcggccggggtCacctggtgcagccgcagcag	5	6	16	14	4	1	1	1	1	0	0	3	1	1	1	4	4	3	3	4	4	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:22179293C>T	uc001bfj.2	-	52	6664	c.6624G>A	c.(6622-6624)GTG>GTA	p.V2208V	HSPG2_uc009vqd.2_Silent_p.V2209V	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2208	Ig-like C2-type 7.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGGCCGGGGTCACCTGGTGCA	0.657													19	44					0	0	0	0	T	22179293	T	T	22179293	2	4	236	1	0	0	0	0	0	0	0	1	7469	813	29	2		2	HSPG2	1	22179293	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3370523	22179293	227071328	3	42641											
SEPN1	57190	broad.mit.edu	37	chr1	26138256	26138256	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcagcatgatcgacagccaCctgccttcaggggagcccct	8	6	12	15	1	1	1	1	1	0	0	2	3	1	2	5	3	4	2	5	3	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:26138256C>T	uc010oer.1	+	11	1222	c.1167C>T	c.(1165-1167)CAC>CAT	p.H389H	SEPN1_uc010oes.1_Silent_p.H355H	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor	389						endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		TCGACAGCCACCTGCCTTCAG	0.647													4	17					0	0	0	0	T	26138256	T	T	26138256	2	4	236	1	0	0	0	0	0	0	0	1	14121	506	18	4		4	SEPN1	1	26138256	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3958963	26138256	223112365	4	42642											
FGR	2268	broad.mit.edu	37	chr1	27949593	27949593	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctcgcccttggtgaaggTgaggtcatcctcagttcgag	6	12	12	11	2	3	2	2	2	1	0	6	3	4	2	2	3	0	1	2	3	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:27949593T>A	uc001boj.2	-	2	435	c.289A>T	c.(289-291)ACC>TCC	p.T97S	FGR_uc001bok.2_Missense_Mutation_p.T97S|FGR_uc001bol.2_Missense_Mutation_p.T97S|FGR_uc001bom.2_Missense_Mutation_p.T97S	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	97	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TTGGTGAAGGTGAGGTCATCC	0.463													16	60					0	0	0	0	A	27949593	A	A	27949593	3	1	236	1	0	0	0	0	1	0	0	0	5906	1696	59	5	1340	5	FGR	1	27949593	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	1811337	27949593	221301028	5	42643											
PTPRF	5792	broad.mit.edu	37	chr1	44054597	44054597	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagctcagcaatgtcgtacGctctgccaactacacctgtg	9	9	10	13	2	2	0	1	0	1	0	3	1	2	1	2	1	6	4	2	1	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:44054597G>T	uc001cjr.2	+	8	1215	c.875G>T	c.(874-876)CGC>CTC	p.R292L	PTPRF_uc001cjs.2_Missense_Mutation_p.R292L|PTPRF_uc001cju.2_5'Flank|PTPRF_uc009vwt.2_5'Flank|PTPRF_uc001cjv.2_5'Flank	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	292	Extracellular (Potential).|Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AATGTCGTACGCTCTGCCAAC	0.597													5	16					4.096e-09	6.94693e-09	1	0	T	44054597	T	T	44054597	3	4	236	1	0	0	0	0	1	0	0	0	12866	1087	38	3	897	3	PTPRF	1	44054597	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	16105004	44054597	205196024	6	42644											
PTPRF	5792	broad.mit.edu	37	chr1	44058190	44058190	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacctgaagcctgacacactCtaccgcttccagctggctgc	8	8	9	16	1	1	2	0	2	1	0	2	3	2	2	4	1	4	3	4	1	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:44058190C>G	uc001cjr.2	+	11	2071	c.1731C>G	c.(1729-1731)CTC>CTG	p.L577L	PTPRF_uc001cjs.2_Silent_p.L577L|PTPRF_uc001cju.2_Silent_p.L148L|PTPRF_uc009vwt.2_Silent_p.L148L|PTPRF_uc001cjv.2_Silent_p.L148L	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	577	Extracellular (Potential).|Fibronectin type-III 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CTGACACACTCTACCGCTTCC	0.602													72	37					0	0	0	0	G	44058190	G	G	44058190	2	3	236	1	0	0	0	0	0	0	0	1	12866	900	32	2		2	PTPRF	1	44058190	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3593	44058190	205192431	7	42645											
PTPRF	5792	broad.mit.edu	37	chr1	44058210	44058210	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctaccgcttccagctggctgCacgctcggatatgggggtgg	5	9	15	12	3	0	0	0	0	0	0	2	1	1	1	2	5	3	5	2	5	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:44058210C>T	uc001cjr.2	+	11	2091	c.1751C>T	c.(1750-1752)GCA>GTA	p.A584V	PTPRF_uc001cjs.2_Missense_Mutation_p.A584V|PTPRF_uc001cju.2_Missense_Mutation_p.A155V|PTPRF_uc009vwt.2_Missense_Mutation_p.A155V|PTPRF_uc001cjv.2_Missense_Mutation_p.A155V	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	584	Extracellular (Potential).|Fibronectin type-III 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CAGCTGGCTGCACGCTCGGAT	0.612													50	32					0	0	0	0	T	44058210	T	T	44058210	3	4	236	1	0	0	0	0	1	0	0	0	12866	710	25	4	1785	4	PTPRF	1	44058210	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	20	44058210	205192411	8	42646											
SPATA6	54558	broad.mit.edu	37	chr1	48764465	48764465	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcttgtccatgctgttctCaaagatgggtcggtgggatt	7	14	12	8	1	2	1	1	0	2	1	5	2	3	2	1	3	1	2	1	3	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:48764465C>A	uc001crr.1	-	13	1552	c.1387G>T	c.(1387-1389)GAG>TAG	p.E463*	SPATA6_uc001crs.1_Nonsense_Mutation_p.E447*|SPATA6_uc010omv.1_Nonsense_Mutation_p.E449*	NM_019073	NP_061946	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6 precursor	463					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				ovary(1)	1						ATGCTGTTCTCAAAGATGGGT	0.468													36	85					1.06647e-15	2.02568e-15	1	0	A	48764465	A	A	48764465	4	1	236	1	0	0	0	0	0	1	0	0	15079	835	29	2	83	2	SPATA6	1	48764465	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4706255	48764465	200486156	9	42647											
LRRIQ3	127255	broad.mit.edu	37	chr1	74506982	74506982	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatcaggcttttctcttttaGgacagcctcattcttctcca	8	16	5	12	0	5	0	2	0	3	0	7	1	5	1	2	2	1	1	2	2	2	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:74506982G>C	uc001dfy.3	-	7	1825	c.1633C>G	c.(1633-1635)CTA>GTA	p.L545V	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	545										ovary(2)	2						TTCTCTTTTAGGACAGCCTCA	0.328													16	48					0	0	0	0	C	74506982	C	C	74506982	3	2	236	1	0	0	0	0	1	0	0	0	9080	991	35	4	249	4	LRRIQ3	1	74506982	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	25742517	74506982	174743639	10	42648											
MSH4	4438	broad.mit.edu	37	chr1	76365339	76365339	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtgtcatcacttccaccatCaattgtcttggatgccaagg	9	12	9	11	0	4	0	3	0	1	0	5	1	5	1	3	3	1	0	3	3	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:76365339C>G	uc001dhd.1	+	19	2608	c.2567C>G	c.(2566-2568)TCA>TGA	p.S856*		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	856					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						CTTCCACCATCAATTGTCTTG	0.303								MMR					16	41					0	0	0	0	G	76365339	G	G	76365339	4	3	236	1	0	0	0	0	0	1	0	0	9925	838	29	2	2641	2	MSH4	1	76365339	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1858357	76365339	172885282	11	42649											
VCAM1	7412	broad.mit.edu	37	chr1	101200228	101200228	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatagatggcgcctataccAtccgaaaggcccagttgaag	12	8	10	11	2	0	2	0	1	0	1	1	3	1	2	4	2	1	1	4	2	6	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:101200228A>G	uc001dti.2	+	8	2083	c.1963A>G	c.(1963-1965)ATC>GTC	p.I655V	VCAM1_uc001dtj.2_Missense_Mutation_p.I563V|VCAM1_uc010ouj.1_Missense_Mutation_p.I593V	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	655	Ig-like C2-type 7.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CGCCTATACCATCCGAAAGGC	0.398													23	17					0	0	0	0	G	101200228	G	G	101200228	3	3	236	1	0	0	0	0	1	0	0	0	17205	217	8	5	1993	5	VCAM1	1	101200228	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	24834889	101200228	148050393	12	42650											
COL11A1	1301	broad.mit.edu	37	chr1	103444450	103444450	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcccagtgggacctcttgcaCctcttgaacctcgaggaccc	7	9	9	16	1	2	1	0	1	2	0	4	4	3	3	5	2	2	1	5	2	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:103444450C>A	uc001dul.2	-	34	2993	c.2675G>T	c.(2674-2676)GGT>GTT	p.G892V	COL11A1_uc001duk.2_Missense_Mutation_p.G88V|COL11A1_uc001dum.2_Missense_Mutation_p.G904V|COL11A1_uc001dun.2_Missense_Mutation_p.G853V|COL11A1_uc009weh.2_Missense_Mutation_p.G776V	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	892	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACCTCTTGCACCTCTTGAACC	0.403													38	25					8.69298e-16	1.65436e-15	1	0	A	103444450	A	A	103444450	3	1	236	1	0	0	0	0	1	0	0	0	3682	507	18	4	2881	4	COL11A1	1	103444450	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2244222	103444450	145806171	13	42651											
C1orf103	55791	broad.mit.edu	37	chr1	111492660	111492660	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcactcttcagatgtaatGccttattacttcttccttga	9	17	4	11	0	4	2	2	1	2	1	5	2	5	2	2	0	2	1	2	0	3	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:111492660G>T	uc001eaa.2	-	3	1938	c.1682C>A	c.(1681-1683)GCA>GAA	p.A561E	C1orf103_uc001dzz.2_Missense_Mutation_p.A25E|C1orf103_uc001eab.2_Missense_Mutation_p.A25E|C1orf103_uc001eac.1_Missense_Mutation_p.A25E	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	561					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		CAGATGTAATGCCTTATTACT	0.378													13	24					5.50884e-06	8.64166e-06	1	0	T	111492660	T	T	111492660	3	4	236	1	0	0	0	0	1	0	0	0	1986	1319	46	4	635	4	C1orf103	1	111492660	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	8048210	111492660	137757961	14	42652											
TBX15	6913	broad.mit.edu	37	chr1	119474274	119474274	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatgatcatttcagttccAatatcatggaaccgcttcca	11	13	7	10	1	3	2	3	2	0	0	5	3	5	3	3	1	1	2	3	1	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:119474274A>C	uc001ehl.1	-	2	384	c.69T>G	c.(67-69)ATT>ATG	p.I23M		NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	129	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		TTTCAGTTCCAATATCATGGA	0.493													9	40					0	0	0	0	C	119474274	C	C	119474274	3	2	236	1	0	0	0	0	1	0	0	0	15718	126	5	5	1449	5	TBX15	1	119474274	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	7981614	119474274	129776347	15	42653											
NBPF10	100132406	broad.mit.edu	37	chr1	145368633	145368633	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aataggttttttactttgacGgtgacaagtctccacctggt	9	15	9	8	1	1	2	0	2	1	0	2	2	1	2	2	3	1	1	2	3	4	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:145368633G>T	uc001end.3	+	86	10871	c.10836G>T	c.(10834-10836)ACG>ACT	p.T3612T	NBPF9_uc010oye.1_Silent_p.T896T|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Silent_p.T465T|NBPF10_uc010oyk.1_Silent_p.T253T|NBPF10_uc010oyl.1_Silent_p.T253T	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3537											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTACTTTGACGGTGACAAGTC	0.458													7	521					1.64113e-05	2.54596e-05	1	0	T	145368633	T	T	145368633	2	4	236	1	0	0	0	0	0	0	0	1	10246	1103	39	3		3	NBPF10	1	145368633	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	25894359	145368633	103881988	16	42654											
GJA8	2703	broad.mit.edu	37	chr1	147380375	147380375	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacgtggggcacgcggtgcActacgtccgcatggaggaga	8	6	17	10	5	0	1	0	0	0	1	1	3	1	2	1	5	3	4	1	5	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:147380375A>T	uc001epu.1	+	2	356	c.293A>T	c.(292-294)CAC>CTC	p.H98L		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	98	Helical; (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					CACGCGGTGCACTACGTCCGC	0.652													17	57					0	0	0	0	T	147380375	T	T	147380375	3	4	236	1	0	0	0	0	1	0	0	0	6442	159	6	5	295	5	GJA8	1	147380375	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	2011742	147380375	101870246	17	42655											
ECM1	1893	broad.mit.edu	37	chr1	150480696	150480696	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccccaggatggggaccaCagccagagcagccttggtct	8	7	13	13	0	1	1	0	0	1	1	1	3	1	3	5	4	4	1	5	4	0	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:150480696C>G	uc001eus.2	+	1	210	c.11C>G	c.(10-12)ACA>AGA	p.T4R	ECM1_uc010pce.1_5'UTR|ECM1_uc010pcf.1_5'UTR|ECM1_uc001eut.2_Missense_Mutation_p.T4R|ECM1_uc001euu.2_Missense_Mutation_p.T4R|ECM1_uc001euv.2_Missense_Mutation_p.T4R|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	4					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			ATGGGGACCACAGCCAGAGCA	0.597													28	55					0	0	0	0	G	150480696	G	G	150480696	3	3	236	1	0	0	0	0	1	0	0	0	4919	478	17	4	13	4	ECM1	1	150480696	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3100321	150480696	98769925	18	42656											
HRNR	388697	broad.mit.edu	37	chr1	152188242	152188242	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agactgcccagaaccagaccCatgtcggccacggctagggc	10	4	12	15	2	0	3	0	0	0	3	1	3	0	3	4	3	2	1	4	3	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:152188242C>A	uc001ezt.1	-	3	5939	c.5863G>T	c.(5863-5865)GGG>TGG	p.G1955W		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1955	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAACCAGACCCATGTCGGCCA	0.617													9	761					0.00621372	0.00910727	1	0	A	152188242	A	A	152188242	3	1	236	1	0	0	0	0	1	0	0	0	7398	594	21	4	2693	4	HRNR	1	152188242	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1707546	152188242	97062379	19	42657											
FLG	2312	broad.mit.edu	37	chr1	152275869	152275869	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcctgagtggaagcttcAtggtgacgcgaccctgagtg	8	9	14	10	2	2	3	2	3	0	0	2	5	2	4	2	2	2	1	2	2	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:152275869A>T	uc001ezu.1	-	3	11529	c.11493T>A	c.(11491-11493)CAT>CAA	p.H3831Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3831	Filaggrin 23.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGAAGCTTCATGGTGACGCG	0.587									Ichthyosis				100	340					0	0	0	0	T	152275869	T	T	152275869	3	4	236	1	0	0	0	0	1	0	0	0	5954	214	8	5	696	5	FLG	1	152275869	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	87627	152275869	96974752	20	42658											
S100A7	6278	broad.mit.edu	37	chr1	153430420	153430420	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctttttctcaaagacatcGgcgaggtaatttgtgccctt	8	15	8	10	2	1	1	1	0	1	1	4	2	2	1	2	2	1	1	2	2	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:153430420G>T	uc001fbv.1	-	3	239	c.168C>A	c.(166-168)GCC>GCA	p.A56A		NM_002963	NP_002954	P31151	S10A7_HUMAN	S100 calcium binding protein A7	56	EF-hand 2.				angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			skin(1)	1	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAAAGACATCGGCGAGGTAAT	0.413													19	51					3.51602e-12	6.26629e-12	1	0	T	153430420	T	T	153430420	2	4	236	1	0	0	0	0	0	0	0	1	13848	1103	39	3		3	S100A7	1	153430420	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1154551	153430420	95820201	21	42659											
FMO3	2328	broad.mit.edu	37	chr1	171077253	171077253	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaaggcaaatgcttccacaGcagggactataaagaaccag	17	6	9	9	0	0	1	0	0	0	1	1	2	1	2	2	2	3	3	2	2	7	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:171077253G>T	uc001ghi.2	+	5	629	c.518G>T	c.(517-519)AGC>ATC	p.S173I	FMO3_uc001ghh.2_Missense_Mutation_p.S173I|FMO3_uc010pmb.1_Missense_Mutation_p.S153I|FMO3_uc010pmc.1_Missense_Mutation_p.S110I	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	173					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGCTTCCACAGCAGGGACTAT	0.438													29	57					3.73148e-12	6.63824e-12	1	0	T	171077253	T	T	171077253	3	4	236	1	0	0	0	0	1	0	0	0	5988	971	34	4	532	4	FMO3	1	171077253	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	17646833	171077253	78173368	22	42660											
FMO2	2327	broad.mit.edu	37	chr1	171168602	171168602	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcaggctcagatattgctgTtgagctgagtaagaatgctg	10	12	12	7	0	2	4	2	2	0	2	2	4	2	4	0	1	3	6	0	1	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:171168602T>G	uc001ghk.1	+	5	719	c.602T>G	c.(601-603)GTT>GGT	p.V201G	FMO2_uc010pmd.1_Intron	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	201					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GATATTGCTGTTGAGCTGAGT	0.498													15	89					0	0	0	0	G	171168602	G	G	171168602	3	3	236	1	0	0	0	0	1	0	0	0	5987	1725	60	5	616	5	FMO2	1	171168602	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	91349	171168602	78082019	23	42661											
TDRD5	163589	broad.mit.edu	37	chr1	179620116	179620116	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaacatttttttgtgtgacAcatcctcaaacgaagatgtc	12	15	6	8	1	1	2	1	1	0	1	3	3	2	2	1	0	2	0	1	0	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:179620116A>G	uc001gnf.1	+	12	2165	c.1915A>G	c.(1915-1917)ACA>GCA	p.T639A	TDRD5_uc010pnp.1_Missense_Mutation_p.T639A|TDRD5_uc001gnh.1_Missense_Mutation_p.T194A	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	639					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						TTTGTGTGACACATCCTCAAA	0.418													23	67					0	0	0	0	G	179620116	G	G	179620116	3	3	236	1	0	0	0	0	1	0	0	0	15799	159	6	5	1957	5	TDRD5	1	179620116	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	8451514	179620116	69630505	24	42662											
FAM5C	339479	broad.mit.edu	37	chr1	190250824	190250824	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gggcaagaggcagaggagagCcaaggaaatttcttctctca	13	7	13	8	0	3	3	1	0	2	3	4	5	3	4	1	4	1	2	1	4	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:190250824C>A	uc001gse.1	-	3	525	c.293G>T	c.(292-294)GGC>GTC	p.G98V	FAM5C_uc010pot.1_Intron	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	98						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CAGAGGAGAGCCAAGGAAATT	0.393													20	23					4.96729e-08	8.23966e-08	1	0	A	190250824	A	A	190250824	3	1	236	1	0	0	0	0	1	0	0	0	5626	739	26	4	2031	4	FAM5C	1	190250824	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	10630708	190250824	58999797	25	42663											
PIGR	5284	broad.mit.edu	37	chr1	207105832	207105832	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtgccgggctctggccacCcccacagccacggctcccac	5	5	10	21	2	1	0	0	0	1	0	2	0	2	0	6	3	2	2	6	3	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:207105832C>A	uc001hez.2	-	8	2161	c.1977G>T	c.(1975-1977)GGG>GGT	p.G659G	PIGR_uc009xbz.2_Silent_p.G659G	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	659	Helical; (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CTCTGGCCACCCCCACAGCCA	0.647													19	82					2.35188e-11	4.13897e-11	1	0	A	207105832	A	A	207105832	2	1	236	1	0	0	0	0	0	0	0	1	11952	610	22	4		4	PIGR	1	207105832	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	16855008	207105832	42144789	26	42664											
CR2	1380	broad.mit.edu	37	chr1	207648236	207648236	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcatgatggcagaaaacttTctatatggaaatgaagtctc	14	11	10	6	0	2	3	0	2	2	1	3	4	2	4	0	3	1	2	0	3	6	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:207648236T>A	uc001hfw.2	+	13	2308	c.2214T>A	c.(2212-2214)TTT>TTA	p.F738L	CR2_uc001hfv.2_Missense_Mutation_p.F797L|CR2_uc009xch.2_Missense_Mutation_p.F738L	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	738	Sushi 12.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						CAGAAAACTTTCTATATGGAA	0.418													24	83					0	0	0	0	A	207648236	A	A	207648236	3	1	236	1	0	0	0	0	1	0	0	0	3857	1780	62	5	2445	5	CR2	1	207648236	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	542404	207648236	41602385	27	42665											
FAM71A	149647	broad.mit.edu	37	chr1	212799980	212799980	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacaccggacatcatggaGacagtgacctttgaagccca	13	7	10	11	1	1	4	1	3	0	1	1	6	1	5	3	2	1	0	3	2	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:212799980G>T	uc001hjk.2	+	1	2165	c.1761G>T	c.(1759-1761)GAG>GAT	p.E587D	uc010pth.1_RNA	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	587										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		ACATCATGGAGACAGTGACCT	0.567													27	112					3.65163e-15	6.92258e-15	1	0	T	212799980	T	T	212799980	3	4	236	1	0	0	0	0	1	0	0	0	5639	933	33	2	1763	2	FAM71A	1	212799980	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	5151744	212799980	36450641	28	42666											
USH2A	7399	broad.mit.edu	37	chr1	216062110	216062110	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gagaacagctctggacttggGatcccttccggtgcccctgg	6	9	13	13	1	1	1	0	0	1	1	3	4	3	3	4	4	3	1	4	4	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:216062110G>C	uc001hku.1	-	41	8268	c.7881C>G	c.(7879-7881)ATC>ATG	p.I2627M		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2627	Extracellular (Potential).|Fibronectin type-III 13.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTGGACTTGGGATCCCTTCCG	0.498										HNSCC(13;0.011)			17	52					0	0	0	0	C	216062110	C	C	216062110	3	2	236	1	0	0	0	0	1	0	0	0	17104	1164	41	2	7855	2	USH2A	1	216062110	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3262130	216062110	33188511	29	42667											
OBSCN	84033	broad.mit.edu	37	chr1	228554824	228554824	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgagccacccgctggtcacgGggctgctggaccagtttgag	6	8	15	12	2	1	2	1	2	0	0	1	3	1	3	3	4	2	4	3	4	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:228554824G>T	uc009xez.1	+	86	19620	c.19576G>T	c.(19576-19578)GGG>TGG	p.G6526W	OBSCN_uc001hsr.1_Missense_Mutation_p.G1155W	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6526	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCTGGTCACGGGGCTGCTGGA	0.652													4	15					3.59834e-05	5.52984e-05	1	0	T	228554824	T	T	228554824	3	4	236	1	0	0	0	0	1	0	0	0	10866	1232	43	4	21124	4	OBSCN	1	228554824	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	12492714	228554824	20695797	30	42668											
C1orf57	84284	broad.mit.edu	37	chr1	233086326	233086326	+	5'Flank	DEL	C	-	-																															cggtgcttccggtcaaagcaCcgcttgggggcggggcctgc																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:233086326delC	uc001hvj.1	+						C1orf57_uc001hvi.2_5'Flank|C1orf57_uc009xft.1_5'Flank	NM_032324	NP_115700	Q9BSD7	NTPCR_HUMAN	nucleoside-triphosphatase C1orf57								ATP binding|nucleoside-triphosphatase activity|nucleotide phosphatase activity|transferase activity				0		all_cancers(173;0.0818)|Prostate(94;0.137)				GGTCAAAGCACCGCTTGGGGG	0.701													---	---	---								-	233086326	-	-	233086326	6	5	236	0	1	1	0	1	0	0	0	0	2059	522	18	0		0	C1orf57	1	233086326	5'Flank	DEL	C	TCGA-CV-7245-01A-11D-2012-08	4531502	233086326	16164295	31	42669											
KIAA1804	84451	broad.mit.edu	37	chr1	233482322	233482322	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctatgcctggatggcccccGaagtgatcaagtcttccttg	7	11	10	13	1	2	1	1	1	1	0	3	3	3	2	5	2	1	0	5	2	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:233482322G>A	uc001hvt.3	+	2	1201	c.940G>A	c.(940-942)GAA>AAA	p.E314K	KIAA1804_uc001hvs.1_Missense_Mutation_p.E314K	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	314	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				GATGGCCCCCGAAGTGATCAA	0.473													5	26					0	0	0	0	A	233482322	A	A	233482322	3	1	236	1	0	0	0	0	1	0	0	0	8298	1059	37	1	946	1	KIAA1804	1	233482322	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	395996	233482322	15768299	32	42670											
RYR2	6262	broad.mit.edu	37	chr1	237796940	237796940	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctctgttacttctgtcgtatAagtaggcagaatcaaaaagc	13	12	8	8	1	3	1	1	0	2	1	4	1	3	1	0	1	2	4	0	1	7	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:237796940A>T	uc001hyl.1	+	43	6738	c.6618A>T	c.(6616-6618)ATA>ATT	p.I2206I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2206	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTGTCGTATAAGTAGGCAGA	0.373													49	125					0	0	0	0	T	237796940	T	T	237796940	2	4	236	1	0	0	0	0	0	0	0	1	13834	352	13	5		5	RYR2	1	237796940	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	4314618	237796940	11453681	33	42671											
FMN2	56776	broad.mit.edu	37	chr1	240255040	240255040	+	5'Flank	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagaggaaacgtttttcgcGcccaggttcagcgaggagcc	10	8	13	10	4	1	1	1	0	0	1	2	4	1	3	2	3	3	2	2	3	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:240255040G>T	uc010pyd.1	+						FMN2_uc010pye.1_5'Flank	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2						actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CGTTTTTCGCGCCCAGGTTCA	0.473													9	19					0.00448238	0.00657952	1	0	T	240255040	T	T	240255040	1	4	236	0	1	0	0	0	0	0	0	0	5982	1102	38	3		3	FMN2	1	240255040	5'Flank	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2458100	240255040	8995581	34	42672											
KIF26B	55083	broad.mit.edu	37	chr1	245530230	245530230	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacaaccgctgtgacatttGcgccactcacctgaaccagt	10	8	9	14	2	1	2	1	2	0	0	1	3	1	3	4	1	3	1	4	1	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:245530230G>C	uc001ibf.1	+	3	1000	c.560G>C	c.(559-561)TGC>TCC	p.C187S	KIF26B_uc010pyq.1_Missense_Mutation_p.C187S|KIF26B_uc010pyr.1_5'UTR	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	187					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			TGTGACATTTGCGCCACTCAC	0.602													8	34					0	0	0	0	C	245530230	C	C	245530230	3	2	236	1	0	0	0	0	1	0	0	0	8334	1319	46	4	570	4	KIF26B	1	245530230	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	5275190	245530230	3720391	35	42673											
ZNF670	93474	broad.mit.edu	37	chr1	247200823	247200823	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctttaccacatttcttacaTtcatagggtttttctccagt	8	18	5	10	0	3	0	1	0	2	0	4	0	3	0	2	1	2	2	2	1	3	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:247200823T>A	uc001icd.1	-	4	1269	c.1098A>T	c.(1096-1098)GAA>GAT	p.E366D	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	366	C2H2-type 9; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			ATTTCTTACATTCATAGGGTT	0.403													28	68					0	0	0	0	A	247200823	A	A	247200823	3	1	236	1	0	0	0	0	1	0	0	0	18144	1490	52	5	75	5	ZNF670	1	247200823	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	1670593	247200823	2049798	36	42674											
NLRP3	114548	broad.mit.edu	37	chr1	247587342	247587342	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accaagacgtgtgagagcccCgtgagtcccattaagatgga	12	7	12	10	2	0	4	0	2	0	3	1	6	1	5	4	1	1	0	4	1	2	1	rs3806267		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr1:247587342C>T	uc001icr.2	+	5	735	c.597C>T	c.(595-597)CCC>CCT	p.P199P	NLRP3_uc001ics.2_Silent_p.P199P|NLRP3_uc001icu.2_Silent_p.P199P|NLRP3_uc001icw.2_Silent_p.P199P|NLRP3_uc001icv.2_Silent_p.P199P|NLRP3_uc010pyw.1_Silent_p.P197P|NLRP3_uc001ict.1_Silent_p.P197P	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	199					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GTGAGAGCCCCGTGAGTCCCA	0.582													21	26					0	0	0	0	T	247587342	T	T	247587342	2	4	236	1	0	0	0	0	0	0	0	1	10532	639	23	1		1	NLRP3	1	247587342	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	386519	247587342	1663279	37	42675											
MSGN1	343930	broad.mit.edu	37	chr2	17998364	17998364	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcccagagcccagagcgcGtgagctccatccggggaaac	10	3	14	14	3	0	3	0	1	0	2	2	5	2	4	4	2	5	1	4	2	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:17998364G>A	uc010yjt.1	+	1	579	c.579G>A	c.(577-579)GCG>GCA	p.A193A		NM_001105569	NP_001099039	A6NI15	MSGN1_HUMAN	mesogenin 1	193					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CCCAGAGCGCGTGAGCTCCAT	0.542													24	21					0	0	0	0	A	17998364	A	A	17998364	2	1	236	1	0	0	0	0	0	0	0	1	9922	1132	40	1		1	MSGN1	2	17998364	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08		17998364	225201009	38	42676											
RASGRP3	25780	broad.mit.edu	37	chr2	33740206	33740206	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacaacggctaaataaccatGggatcaagtggccttgggaa	14	7	12	8	1	1	0	1	0	0	0	1	3	1	2	2	4	2	1	2	4	6	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:33740206G>C	uc002rox.2	+	4	630	c.3G>C	c.(1-3)ATG>ATC	p.M1I	RASGRP3_uc010ync.1_Missense_Mutation_p.M1I|RASGRP3_uc002roy.2_Missense_Mutation_p.M1I	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	1					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					AAATAACCATGGGATCAAGTG	0.428													20	89					0	0	0	0	C	33740206	C	C	33740206	3	2	236	1	0	0	0	0	1	0	0	0	13141	1348	47	4	5	4	RASGRP3	2	33740206	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	15741842	33740206	209459167	39	42677											
CRIM1	51232	broad.mit.edu	37	chr2	36583743	36583743	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatggcgactccctcaccgAgtacgaagcgggcgtttgcg	8	7	13	13	6	1	0	1	0	0	0	2	3	2	0	2	2	3	2	2	2	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:36583743A>G	uc002rpd.2	+	1	347	c.308A>G	c.(307-309)GAG>GGG	p.E103G		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	103	IGFBP N-terminal.|Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				TCCCTCACCGAGTACGAAGCG	0.687													11	53					0	0	0	0	G	36583743	G	G	36583743	3	3	236	1	0	0	0	0	1	0	0	0	3888	304	11	5	310	5	CRIM1	2	36583743	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	2843537	36583743	206615630	40	42678											
HEATR5B	54497	broad.mit.edu	37	chr2	37235842	37235842	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccacaggcgactgagtgtTggtagttcaggttgtaccag	10	10	13	8	1	1	1	1	1	0	0	1	2	1	1	2	3	2	5	2	3	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:37235842T>C	uc002rpp.1	-	28	4530	c.4434A>G	c.(4432-4434)CCA>CCG	p.P1478P	HEATR5B_uc010ezy.1_Silent_p.P62P|HEATR5B_uc002rpq.3_Silent_p.P62P	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1478							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				GACTGAGTGTTGGTAGTTCAG	0.413													12	79					0	0	0	0	C	37235842	C	C	37235842	2	2	236	1	0	0	0	0	0	0	0	1	7071	1799	63	5		5	HEATR5B	2	37235842	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	652099	37235842	205963531	41	42679											
EPAS1	2034	broad.mit.edu	37	chr2	46607729	46607729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagatccaatacccagtggCccccagatccaccattacat	12	7	6	16	0	0	2	0	0	0	2	2	2	2	2	6	1	2	1	6	1	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:46607729C>T	uc002ruv.2	+	12	2406	c.1918C>T	c.(1918-1920)CCC>TCC	p.P640S	EPAS1_uc002ruw.2_Missense_Mutation_p.P106S	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	640					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			TACCCAGTGGCCCCCAGATCC	0.617													52	100					0	0	0	0	T	46607729	T	T	46607729	3	4	236	1	0	0	0	0	1	0	0	0	5174	739	26	4	1964	4	EPAS1	2	46607729	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	9371887	46607729	196591644	42	42680											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48874155	48874155	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaccaagaaatatagaggaaCccagcaacatacctgtatca	19	6	6	10	0	1	2	1	0	0	2	1	3	1	3	3	1	5	2	3	1	9	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:48874155C>T	uc010yol.1	+	5	2970	c.2923C>T	c.(2923-2925)CCC>TCC	p.P975S	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.P1022S|GTF2A1L_uc002rws.1_Missense_Mutation_p.P318S|GTF2A1L_uc010yom.1_Missense_Mutation_p.P284S|GTF2A1L_uc002rwt.2_Missense_Mutation_p.P318S	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	975					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TATAGAGGAACCCAGCAACAT	0.413													7	25					0	0	0	0	T	48874155	T	T	48874155	3	4	236	1	0	0	0	0	1	0	0	0	15383	507	18	4	3090	4	STON1-GTF2A1L	2	48874155	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2266426	48874155	194325218	43	42681											
FSHR	2492	broad.mit.edu	37	chr2	49190015	49190015	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctataaatttgggcttgcaTttcatagcagccacacttgc	10	13	7	11	0	1	0	1	0	0	0	1	0	1	0	2	1	4	3	2	1	4	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:49190015T>A	uc002rww.2	-	10	2019	c.1945A>T	c.(1945-1947)ATG>TTG	p.M649L	FSHR_uc002rwx.2_Missense_Mutation_p.M587L|FSHR_uc010fbn.2_Missense_Mutation_p.M623L	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	649	Cytoplasmic (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TGGGCTTGCATTTCATAGCAG	0.483									Gonadal_Dysgenesis_46_XX				13	40					0	0	0	0	A	49190015	A	A	49190015	3	1	236	1	0	0	0	0	1	0	0	0	6107	1493	52	5	146	5	FSHR	2	49190015	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	315860	49190015	194009358	44	42682											
NRXN1	9378	broad.mit.edu	37	chr2	50724827	50724827	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctatgttatggaactccagCctagtatgatcacctgccat	10	13	7	11	0	2	1	1	1	1	0	3	2	3	2	4	1	3	2	4	1	5	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:50724827C>A	uc010fbq.2	-	14	4120	c.2643G>T	c.(2641-2643)AGG>AGT	p.R881S	NRXN1_uc002rxb.3_Missense_Mutation_p.R513S|NRXN1_uc002rxe.3_Missense_Mutation_p.R841S|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGAACTCCAGCCTAGTATGAT	0.388													12	46					7.93312e-07	1.2771e-06	1	0	A	50724827	A	A	50724827	3	1	236	1	0	0	0	0	1	0	0	0	10719	738	26	4	2303	4	NRXN1	2	50724827	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1534812	50724827	192474546	45	42683											
PSME4	23198	broad.mit.edu	37	chr2	54137242	54137242	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtatacaactttgtctCttccaaggacaccatacttg	11	13	5	12	0	1	0	0	0	1	0	4	1	3	1	3	1	3	1	3	1	5	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:54137242C>A	uc002rxp.2	-	21	2598	c.2542G>T	c.(2542-2544)GAG>TAG	p.E848*	PSME4_uc010yop.1_Nonsense_Mutation_p.E734*|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Nonsense_Mutation_p.E223*|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	848					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AACTTTGTCTCTTCCAAGGAC	0.333													91	105					1.09269e-41	2.30262e-41	1	0	A	54137242	A	A	54137242	4	1	236	1	0	0	0	0	0	1	0	0	12771	922	32	2	3093	2	PSME4	2	54137242	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3412415	54137242	189062131	46	42684											
ARHGAP25	9938	broad.mit.edu	37	chr2	69043495	69043495	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctcctgagctacatctgcagGtgagaggcccctggtatcaa	9	9	11	12	0	2	2	1	2	1	1	3	3	3	2	3	3	3	3	3	3	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:69043495G>T	uc002seu.2	+	7	1242	c.878_splice	c.e7+1	p.R293_splice	ARHGAP25_uc010fdg.2_Splice_Site_p.R294_splice|ARHGAP25_uc010yql.1_Splice_Site_p.R254_splice|ARHGAP25_uc002sev.2_Splice_Site_p.R287_splice|ARHGAP25_uc002sew.2_Splice_Site_p.R286_splice|ARHGAP25_uc002sex.2_Splice_Site_p.R287_splice|ARHGAP25_uc010fdh.1_Splice_Site|ARHGAP25_uc002sey.2_Splice_Site_p.R20_splice	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						ACATCTGCAGGTGAGAGGCCC	0.488													13	50					7.93312e-07	1.2771e-06	1	0	T	69043495	T	T	69043495	5	4	236	1	0	0	0	0	0	0	1	0	874	1275	44	4	948	4	ARHGAP25	2	69043495	Splice_Site	SNP	G	TCGA-CV-7245-01A-11D-2012-08	14906253	69043495	174155878	47	42685											
EXOC6B	23233	broad.mit.edu	37	chr2	72722617	72722617	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gataaattctttaatttggtTgtaaacttttggcacaaatt	13	18	6	4	0	1	0	0	0	1	0	1	1	1	0	0	2	1	3	0	2	6	10			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:72722617T>A	uc010fep.2	-	15	1633	c.1495A>T	c.(1495-1497)AAC>TAC	p.N499Y	EXOC6B_uc002sij.2_Missense_Mutation_p.N499Y	NM_015189	NP_056004	Q9Y2D4	EXC6B_HUMAN	SEC15-like 2	499					protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2						TTAATTTGGTTGTAAACTTTT	0.313													3	19					0	0	0	0	A	72722617	A	A	72722617	3	1	236	1	0	0	0	0	1	0	0	0	5333	1812	63	5	972	5	EXOC6B	2	72722617	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	3679122	72722617	170476756	48	42686											
DQX1	165545	broad.mit.edu	37	chr2	74750470	74750470	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtcctgagtcgatgacatgTtggatggaagggagggagaa	12	8	17	4	1	0	3	0	2	0	1	2	8	1	6	1	4	0	1	1	4	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:74750470T>A	uc010yrw.1	-	5	1176	c.1011A>T	c.(1009-1011)CAA>CAT	p.Q337H	DQX1_uc002smc.2_5'UTR	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	337	Helicase C-terminal.					nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						CGATGACATGTTGGATGGAAG	0.542													50	236					0	0	0	0	A	74750470	A	A	74750470	3	1	236	1	0	0	0	0	1	0	0	0	4773	1722	60	5	1174	5	DQX1	2	74750470	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2027853	74750470	168448903	49	42687											
C2orf65	130951	broad.mit.edu	37	chr2	74867187	74867187	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagggaggatgcactcatgCtgatcttgtaccatgtataa	13	11	10	7	0	2	1	1	1	1	0	2	3	2	3	1	2	3	4	1	2	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:74867187C>T	uc002smy.2	-	2	333	c.216G>A	c.(214-216)CAG>CAA	p.Q72Q	C2orf65_uc010ysa.1_Silent_p.Q72Q|C2orf65_uc002smz.2_Silent_p.Q72Q	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	72					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						TGCACTCATGCTGATCTTGTA	0.333													27	26					0	0	0	0	T	74867187	T	T	74867187	2	4	236	1	0	0	0	0	0	0	0	1	2194	796	28	4		4	C2orf65	2	74867187	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	116717	74867187	168332186	50	42688											
LRRTM4	80059	broad.mit.edu	37	chr2	77745762	77745762	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatactcttgctctgcgccAggaatctgaaaccctgggga	9	10	10	12	1	4	1	1	1	3	0	4	3	4	3	2	3	4	1	2	3	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:77745762A>T	uc002snr.2	-	3	1648	c.1233T>A	c.(1231-1233)CCT>CCA	p.P411P	LRRTM4_uc002snq.2_Silent_p.P411P|LRRTM4_uc002sns.2_Silent_p.P411P|LRRTM4_uc002snt.2_Silent_p.P412P	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	411	Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GCTCTGCGCCAGGAATCTGAA	0.483													12	62					0	0	0	0	T	77745762	T	T	77745762	2	4	236	1	0	0	0	0	0	0	0	1	9092	175	7	5		5	LRRTM4	2	77745762	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	2878575	77745762	165453611	51	42689											
REG1A	5967	broad.mit.edu	37	chr2	79348716	79348716	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccagacagagttgccccaGgcccggatcagctgcccaga	9	4	12	16	1	1	3	1	0	0	3	1	4	1	4	5	2	3	2	5	2	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:79348716G>T	uc002snz.2	+	3	196	c.93G>T	c.(91-93)CAG>CAT	p.Q31H	REG1A_uc010ffx.1_Missense_Mutation_p.Q31H|REG1A_uc010ysd.1_Missense_Mutation_p.Q31H	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	31					positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						AGTTGCCCCAGGCCCGGATCA	0.517													101	219					4.18329e-38	8.74041e-38	1	0	T	79348716	T	T	79348716	3	4	236	1	0	0	0	0	1	0	0	0	13275	991	35	4	99	4	REG1A	2	79348716	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1602954	79348716	163850657	52	42690											
LRRTM1	347730	broad.mit.edu	37	chr2	80530349	80530349	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaaagagttgcgcgccagaCtcttgagctgattgtatccg	9	10	12	10	4	1	4	0	2	1	2	2	5	2	4	2	0	2	3	2	0	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:80530349C>A	uc002sok.1	-	2	866	c.596G>T	c.(595-597)AGT>ATT	p.S199I	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	199	LRR 5.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GCGCGCCAGACTCTTGAGCTG	0.582										HNSCC(69;0.2)			33	88					3.90053e-15	7.38019e-15	1	0	A	80530349	A	A	80530349	3	1	236	1	0	0	0	0	1	0	0	0	9089	565	20	4	976	4	LRRTM1	2	80530349	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1181633	80530349	162669024	53	42691											
ACTR1B	10120	broad.mit.edu	37	chr2	98275915	98275915	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgccgtgctccatggggtagCggatggtcagcagcccccgg	5	6	16	14	4	1	0	1	0	0	0	2	1	2	1	4	5	4	3	4	5	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:98275915C>T	uc002syb.2	-	4	423	c.215G>A	c.(214-216)CGC>CAC	p.R72H		NM_005735	NP_005726	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B,	72						centrosome|dynactin complex	ATP binding|protein binding			skin(1)	1						CATGGGGTAGCGGATGGTCAG	0.647													58	139					0	0	0	0	T	98275915	T	T	98275915	3	4	236	1	0	0	0	0	1	0	0	0	210	768	27	1	947	1	ACTR1B	2	98275915	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	17745566	98275915	144923458	54	42692											
INPP4A	3631	broad.mit.edu	37	chr2	99155434	99155434	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcattgcgaaaggacactttGctgaaatcgggtaaacagct	13	10	10	8	2	1	1	1	1	0	0	2	3	1	2	0	2	4	3	0	2	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:99155434G>A	uc002syy.2	+	9	1053	c.660G>A	c.(658-660)TTG>TTA	p.L220L	INPP4A_uc010yvj.1_Silent_p.L220L|INPP4A_uc010yvk.1_Silent_p.L220L|INPP4A_uc002syx.2_Silent_p.L220L|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	220					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						AGGACACTTTGCTGAAATCGG	0.488													7	9					0	0	0	0	A	99155434	A	A	99155434	2	1	236	1	0	0	0	0	0	0	0	1	7791	1310	46	4		4	INPP4A	2	99155434	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	879519	99155434	144043939	55	42693											
AFF3	3899	broad.mit.edu	37	chr2	100199351	100199351	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaactgttgccattaggtCggctggaagaagttaagtcc	12	10	11	8	1	0	1	0	0	0	1	2	2	1	2	2	3	2	3	2	3	5	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:100199351C>A	uc002tag.2	-	16	2938	c.2702G>T	c.(2701-2703)CGA>CTA	p.R901L	AFF3_uc002taf.2_Missense_Mutation_p.R926L|AFF3_uc010fiq.1_Missense_Mutation_p.R901L|AFF3_uc010yvr.1_Missense_Mutation_p.R1054L|AFF3_uc002tah.1_Missense_Mutation_p.R926L	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	901					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GCCATTAGGTCGGCTGGAAGA	0.483													29	42					7.38237e-10	1.26739e-09	1	0	A	100199351	A	A	100199351	3	1	236	1	0	0	0	0	1	0	0	0	358	884	31	3	1014	3	AFF3	2	100199351	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1043917	100199351	143000022	56	42694											
TGFBRAP1	9392	broad.mit.edu	37	chr2	105889341	105889341	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtggactcggtataaatcaGatttctggagcagccgccgc	10	9	12	10	3	2	1	1	0	1	1	3	3	2	3	2	3	2	2	2	3	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:105889341G>C	uc002tcq.2	-	10	2027	c.1943C>G	c.(1942-1944)TCT>TGT	p.S648C	TGFBRAP1_uc010fjc.2_Missense_Mutation_p.S417C|TGFBRAP1_uc002tcr.3_Missense_Mutation_p.S648C	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	648					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						GTATAAATCAGATTTCTGGAG	0.557													19	46					0	0	0	0	C	105889341	C	C	105889341	3	2	236	1	0	0	0	0	1	0	0	0	15890	942	33	2	651	2	TGFBRAP1	2	105889341	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	5689990	105889341	137310032	57	42695											
FBLN7	129804	broad.mit.edu	37	chr2	112942839	112942839	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaccacatgcatcaacacCggtggaagcttccagtgtgt	10	8	12	11	1	1	0	1	0	0	0	2	2	2	2	3	3	3	2	3	3	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:112942839C>T	uc002tho.1	+	7	1141	c.870C>T	c.(868-870)ACC>ACT	p.T290T	FBLN7_uc002thn.2_Silent_p.T290T|FBLN7_uc010fki.1_Silent_p.T244T|FBLN7_uc010fkj.1_Silent_p.T156T	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	290	EGF-like 3; calcium-binding (Potential).				cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						GCATCAACACCGGTGGAAGCT	0.582													20	89					0	0	0	0	T	112942839	T	T	112942839	2	4	236	1	0	0	0	0	0	0	0	1	5733	639	23	1		1	FBLN7	2	112942839	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	7053498	112942839	130256534	58	42696											
POLR1B	84172	broad.mit.edu	37	chr2	113316883	113316883	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tattaaggtcttggcctcctAcaagattctggactttgtgt	8	16	9	8	0	2	1	0	0	2	1	3	2	3	2	2	3	1	0	2	3	4	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:113316883A>G	uc002thw.2	+	9	1924	c.1344A>G	c.(1342-1344)CTA>CTG	p.L448L	POLR1B_uc010fkn.2_Silent_p.L392L|POLR1B_uc002thx.2_Silent_p.L309L|POLR1B_uc010fko.2_Intron|POLR1B_uc010fkp.2_Intron|POLR1B_uc010yxn.1_Silent_p.L486L|POLR1B_uc002thy.2_Silent_p.L309L|POLR1B_uc010yxo.1_Silent_p.L225L	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	448					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						TTGGCCTCCTACAAGATTCTG	0.433													62	215					0	0	0	0	G	113316883	G	G	113316883	2	3	236	1	0	0	0	0	0	0	0	1	12265	378	14	5		5	POLR1B	2	113316883	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	374044	113316883	129882490	59	42697											
LRP1B	53353	broad.mit.edu	37	chr2	141458106	141458106	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttctgccaaatatccatggGcacaagcacaagttctccgg	11	9	8	13	1	2	0	0	0	2	0	4	0	3	0	3	2	2	3	3	2	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:141458106G>T	uc002tvj.1	-	41	7484	c.6512C>A	c.(6511-6513)GCC>GAC	p.A2171D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2171	Extracellular (Potential).|EGF-like 5.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATATCCATGGGCACAAGCACA	0.408										TSP Lung(27;0.18)			14	91					2.62699e-14	4.86736e-14	1	0	T	141458106	T	T	141458106	3	4	236	1	0	0	0	0	1	0	0	0	9005	1203	42	4	7491	4	LRP1B	2	141458106	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	28141223	141458106	101741267	60	42698											
LRP1B	53353	broad.mit.edu	37	chr2	142004851	142004851	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaggtagccttccacacaaCtgcaagtgtaggatccatgt	11	11	9	10	0	0	0	0	0	0	0	2	1	2	1	3	2	3	3	3	2	5	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:142004851C>G	uc002tvj.1	-	5	1508	c.536G>C	c.(535-537)AGT>ACT	p.S179T	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	179	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCCACACAACTGCAAGTGTA	0.388										TSP Lung(27;0.18)			27	66					0	0	0	0	G	142004851	G	G	142004851	3	3	236	1	0	0	0	0	1	0	0	0	9005	565	20	4	13611	4	LRP1B	2	142004851	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	546745	142004851	101194522	61	42699											
NMI	9111	broad.mit.edu	37	chr2	152138463	152138463	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaataattaagagagtaccTggaattctttggtagcctct	14	13	8	6	0	2	1	0	0	2	1	2	3	2	2	2	2	2	2	2	2	7	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:152138463T>C	uc002txi.2	-	3	506	c.176A>G	c.(175-177)CAG>CGG	p.Q59R	NMI_uc010zbx.1_Missense_Mutation_p.Q59R|NMI_uc002txj.2_Intron	NM_004688	NP_004679	Q13287	NMI_HUMAN	N-myc and STAT interactor	59					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity				0				BRCA - Breast invasive adenocarcinoma(221;0.0571)		AGAGAGTACCTGGAATTCTTT	0.284													14	53					0	0	0	0	C	152138463	C	C	152138463	3	2	236	1	0	0	0	0	1	0	0	0	10551	1594	55	5	771	5	NMI	2	152138463	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	10133612	152138463	91060910	62	42700											
KCNJ3	3760	broad.mit.edu	37	chr2	155566132	155566132	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagtctcggcagacacctgaGggtgagttccttccccttga	7	11	11	12	1	1	4	0	3	1	1	4	4	3	4	4	2	0	2	4	2	1	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:155566132G>A	uc002tyv.1	+	2	915	c.720G>A	c.(718-720)GAG>GAA	p.E240E	KCNJ3_uc010zce.1_Intron	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	240	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	AGACACCTGAGGGTGAGTTCC	0.448													25	70					0	0	0	0	A	155566132	A	A	155566132	2	1	236	1	0	0	0	0	0	0	0	1	8091	991	35	4		4	KCNJ3	2	155566132	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3427669	155566132	87633241	63	42701											
DPP4	1803	broad.mit.edu	37	chr2	162876781	162876781	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctatcccgatgacttcccagGtgccttttgtaataaatgtg	9	14	8	10	1	0	1	0	1	0	0	2	2	2	1	3	1	1	1	3	1	4	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:162876781G>T	uc002ubz.2	-	14	1763	c.1202C>A	c.(1201-1203)ACC>AAC	p.T401N	DPP4_uc010fpb.2_Missense_Mutation_p.T77N	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	401	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	GACTTCCCAGGTGCCTTTTGT	0.333													14	48					4.93089e-13	8.98355e-13	1	0	T	162876781	T	T	162876781	3	4	236	1	0	0	0	0	1	0	0	0	4751	1261	44	4	1150	4	DPP4	2	162876781	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	7310649	162876781	80322592	64	42702											
SCN1A	6323	broad.mit.edu	37	chr2	166892851	166892851	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcaagtggtttaatttcatCtaaaatcttttgtttcctaa	12	19	4	6	0	4	0	2	0	2	0	5	0	5	0	1	1	0	2	1	1	5	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:166892851C>G	uc010zcz.1	-	16	3121	c.3103G>C	c.(3103-3105)GAT>CAT	p.D1035H	SCN1A_uc002udo.3_Missense_Mutation_p.D915H|SCN1A_uc010fpk.2_Missense_Mutation_p.D887H	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1046						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTAATTTCATCTAAAATCTTT	0.318													26	25					0	0	0	0	G	166892851	G	G	166892851	3	3	236	1	0	0	0	0	1	0	0	0	13979	913	32	2	2937	2	SCN1A	2	166892851	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4016070	166892851	76306522	65	42703											
XIRP2	129446	broad.mit.edu	37	chr2	168107290	168107290	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatcacaatagaatctactGcccgacgaacagaaaaccct	16	8	5	12	2	2	2	1	0	1	2	2	4	2	2	2	0	4	0	2	0	8	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:168107290G>T	uc002udx.2	+	8	9406	c.9388G>T	c.(9388-9390)GCC>TCC	p.A3130S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.A2955S|XIRP2_uc010fpq.2_Missense_Mutation_p.A2908S|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2955					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGAATCTACTGCCCGACGAAC	0.438													41	42					1.30998e-17	2.54733e-17	1	0	T	168107290	T	T	168107290	3	4	236	1	0	0	0	0	1	0	0	0	17498	1319	46	4	9418	4	XIRP2	2	168107290	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1214439	168107290	75092083	66	42704											
LRP2	4036	broad.mit.edu	37	chr2	170028586	170028586	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcacactgccaacgaagAgggatgcagtggtgattttt	11	10	11	9	1	1	2	1	1	0	1	1	4	1	3	2	2	3	1	2	2	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:170028586A>G	uc002ues.2	-	58	11415	c.11202T>C	c.(11200-11202)CCT>CCC	p.P3734P		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3734	LDL-receptor class A 31.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GCCAACGAAGAGGGATGCAGT	0.473													41	45					0	0	0	0	G	170028586	G	G	170028586	2	3	236	1	0	0	0	0	0	0	0	1	9006	291	11	5		5	LRP2	2	170028586	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	1921296	170028586	73170787	67	42705											
TTN	7273	broad.mit.edu	37	chr2	179395060	179395060	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtctgaagaaacagttgtatCctgcaacccagtaacaatta	15	10	7	9	0	1	2	0	1	1	1	2	2	2	2	2	0	4	4	2	0	7	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:179395060C>G	uc010zfg.1	-	307	98802	c.98578G>C	c.(98578-98580)GAT>CAT	p.D32860H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D26555H|TTN_uc010zfi.1_Missense_Mutation_p.D26488H|TTN_uc010zfj.1_Missense_Mutation_p.D26363H|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33787							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGTTGTATCCTGCAACCCA	0.428													27	123					0	0	0	0	G	179395060	G	G	179395060	3	3	236	1	0	0	0	0	1	0	0	0	16803	855	30	2	1717	2	TTN	2	179395060	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	9366474	179395060	63804313	68	42706											
TTN	7273	broad.mit.edu	37	chr2	179419418	179419418	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctggaggccgccagagaagGgtgatcttctcagcagttac	9	8	14	10	1	2	2	1	1	2	1	3	4	2	3	2	3	2	3	2	3	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:179419418G>T	uc010zfg.1	-	281	81176	c.80952C>A	c.(80950-80952)ACC>ACA	p.T26984T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T20679T|TTN_uc010zfi.1_Silent_p.T20612T|TTN_uc010zfj.1_Silent_p.T20487T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27911							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCAGAGAAGGGTGATCTTCT	0.473													61	82					3.84483e-29	7.96546e-29	1	0	T	179419418	T	T	179419418	2	4	236	1	0	0	0	0	0	0	0	1	16803	1219	43	4		4	TTN	2	179419418	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	24358	179419418	63779955	69	42707											
TTN	7273	broad.mit.edu	37	chr2	179442239	179442239	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacaattgttggtgcctcTgcaaagaaaaaaatacattt	16	11	8	6	0	1	1	0	0	1	1	1	2	1	2	1	2	3	2	1	2	6	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:179442239T>C	uc010zfg.1	-	273	61345	c.61121_splice	c.e273-1	p.E20374_splice	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Splice_Site_p.E14069_splice|TTN_uc010zfi.1_Splice_Site_p.E14002_splice|TTN_uc010zfj.1_Splice_Site_p.E13877_splice|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGTGCCTCTGCAAAGAAAA	0.343													13	34					0	0	0	0	C	179442239	C	C	179442239	5	2	236	1	0	0	0	0	0	0	1	0	16803	1594	55	5	39312	5	TTN	2	179442239	Splice_Site	SNP	T	TCGA-CV-7245-01A-11D-2012-08	22821	179442239	63757134	70	42708											
TTN	7273	broad.mit.edu	37	chr2	179490067	179490067	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggacttccccagcatcttcTaactttacatccctcagagt	9	13	5	14	0	3	1	1	0	2	1	5	2	5	2	3	1	3	1	3	1	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:179490067T>C	uc010zfg.1	-	190	37001	c.36777A>G	c.(36775-36777)TTA>TTG	p.L12259L	TTN_uc010zfh.1_Silent_p.L5954L|TTN_uc010zfi.1_Silent_p.L5887L|TTN_uc010zfj.1_Silent_p.L5762L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13186							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCATCTTCTAACTTTACAT	0.353													119	90					0	0	0	0	C	179490067	C	C	179490067	2	2	236	1	0	0	0	0	0	0	0	1	16803	1519	53	5		5	TTN	2	179490067	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	47828	179490067	63709306	71	42709											
TTN	7273	broad.mit.edu	37	chr2	179578835	179578835	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtgccagctactgtacaCtccaaggtacaggtgtctcc	8	9	12	12	0	1	0	0	0	1	0	3	0	2	0	3	4	5	3	3	4	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:179578835C>T	uc010zfg.1	-	89	23042	c.22818G>A	c.(22816-22818)GAG>GAA	p.E7606E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.E4267E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8533							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTACTGTACACTCCAAGGTAC	0.388													8	36					0	0	0	0	T	179578835	T	T	179578835	2	4	236	1	0	0	0	0	0	0	0	1	16803	564	20	4		4	TTN	2	179578835	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	88768	179578835	63620538	72	42710											
TTN	7273	broad.mit.edu	37	chr2	179612696	179612696	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacatcacctctgtggtCttccaaagtggcatctgtat	9	13	8	11	0	4	1	1	1	3	0	5	1	5	1	2	2	1	2	2	2	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:179612696C>A	uc002unb.2	-	46	14655	c.14431G>T	c.(14431-14433)GAC>TAC	p.D4811Y	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCTGTGGTCTTCCAAAGTG	0.483													9	52					0.000274275	0.000410576	1	0	A	179612696	A	A	179612696	3	1	236	1	0	0	0	0	1	0	0	0	16803	913	32	2	95866	2	TTN	2	179612696	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	33861	179612696	63586677	73	42711											
TTN	7273	broad.mit.edu	37	chr2	179617888	179617888	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcttgttcaatcctctcAtgcaaaattgattcaggagc	11	14	6	10	0	4	1	3	1	2	0	7	2	5	2	1	1	2	2	1	1	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:179617888A>G	uc010zfg.1	-	45	10547	c.10323T>C	c.(10321-10323)CAT>CAC	p.H3441H	TTN_uc010zfh.1_Silent_p.H3587H|TTN_uc010zfi.1_Silent_p.H3520H|TTN_uc010zfj.1_Silent_p.H3395H|TTN_uc002umz.1_Silent_p.H102H|TTN_uc002unb.2_Silent_p.H3441H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAATCCTCTCATGCAAAATTG	0.284													7	30					0	0	0	0	G	179617888	G	G	179617888	2	3	236	1	0	0	0	0	0	0	0	1	16803	214	8	5		5	TTN	2	179617888	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	5192	179617888	63581485	74	42712											
ZNF804A	91752	broad.mit.edu	37	chr2	185801353	185801353	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgaagaggttaacataacTatacataagaaaacaaattt	21	10	5	5	0	0	3	0	1	0	2	0	3	0	3	0	1	4	1	0	1	9	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:185801353T>A	uc002uph.2	+	4	1824	c.1230T>A	c.(1228-1230)ACT>ACA	p.T410T		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	410						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TTAACATAACTATACATAAGA	0.383													34	106					0	0	0	0	A	185801353	A	A	185801353	2	1	236	1	0	0	0	0	0	0	0	1	18237	1509	53	5		5	ZNF804A	2	185801353	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	6183465	185801353	57398020	75	42713											
ZNF804A	91752	broad.mit.edu	37	chr2	185803105	185803105	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaactgagtggctgcgttaTaattcaggaatccttaacac	12	11	8	10	1	1	1	1	1	0	0	2	2	2	2	2	2	3	2	2	2	5	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:185803105T>A	uc002uph.2	+	4	3576	c.2982T>A	c.(2980-2982)TAT>TAA	p.Y994*		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	994						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GGCTGCGTTATAATTCAGGAA	0.433													44	47					0	0	0	0	A	185803105	A	A	185803105	4	1	236	1	0	0	0	0	0	1	0	0	18237	1413	49	5	2996	5	ZNF804A	2	185803105	Nonsense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	1752	185803105	57396268	76	42714											
COL3A1	1281	broad.mit.edu	37	chr2	189868759	189868759	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccaggcaaggatgggcccCcaggtcctgcgggtaacact	8	6	13	14	1	0	0	0	0	0	0	2	1	2	1	4	5	2	2	4	5	2	1	rs112640146		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:189868759C>A	uc002uqj.1	+	39	2830	c.2713C>A	c.(2713-2715)CCA>ACA	p.P905T		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	905	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGATGGGCCCCCAGGTCCTGC	0.527													6	27					0.00116845	0.00173325	1	0	A	189868759	A	A	189868759	3	1	236	1	0	0	0	0	1	0	0	0	3703	623	22	4	2867	4	COL3A1	2	189868759	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4065654	189868759	53330614	77	42715											
DNAH7	56171	broad.mit.edu	37	chr2	196753557	196753557	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacttctaaatccattggcTcaaaaattagattcatttgt	14	15	4	8	0	3	1	2	0	1	1	4	1	4	1	1	1	1	1	1	1	6	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:196753557T>A	uc002utj.3	-	32	5296	c.5195A>T	c.(5194-5196)GAG>GTG	p.E1732V		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1732	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATCCATTGGCTCAAAAATTAG	0.343													10	33					0	0	0	0	A	196753557	A	A	196753557	3	1	236	1	0	0	0	0	1	0	0	0	4628	1551	54	5	7015	5	DNAH7	2	196753557	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	6884798	196753557	46445816	78	42716											
SF3B1	23451	broad.mit.edu	37	chr2	198263271	198263271	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgggggtgagtctaggcagCagatctttaattggtggagt	9	12	16	4	0	2	2	0	1	2	1	2	3	2	3	0	5	1	2	0	5	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:198263271C>G	uc002uue.2	-	21	3096	c.3048G>C	c.(3046-3048)CTG>CTC	p.L1016L		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	1016	HEAT 8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTCTAGGCAGCAGATCTTTAA	0.353													31	75					0	0	0	0	G	198263271	G	G	198263271	2	3	236	1	0	0	0	0	0	0	0	1	14214	697	25	4		4	SF3B1	2	198263271	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1509714	198263271	44936102	79	42717											
BOLL	66037	broad.mit.edu	37	chr2	198646475	198646475	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aattcctcctacaaagatgcGattagggatcactgttccat	12	12	7	10	1	1	1	1	0	0	1	4	3	4	2	3	1	2	1	3	1	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:198646475G>A	uc002uus.2	-	2	410	c.100C>T	c.(100-102)CGC>TGC	p.R34C	BOLL_uc002uur.2_Missense_Mutation_p.R40C|BOLL_uc002uut.2_Missense_Mutation_p.R46C|BOLL_uc010zha.1_5'UTR|BOLL_uc002uuu.1_Missense_Mutation_p.R40C	NM_033030	NP_149019	Q8N9W6	BOLL_HUMAN	boule isoform 2	34	RRM.				cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2						ACAAAGATGCGATTAGGGATC	0.363													27	98					0	0	0	0	A	198646475	A	A	198646475	3	1	236	1	0	0	0	0	1	0	0	0	1492	1058	37	1	791	1	BOLL	2	198646475	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	383204	198646475	44552898	80	42718											
FAM126B	285172	broad.mit.edu	37	chr2	201846100	201846100	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcgccagcttgacctagccGgtcttcctgcagactgacag	7	10	10	14	2	1	3	0	2	1	1	3	3	2	3	4	1	3	2	4	1	1	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:201846100G>T	uc002uws.3	-	12	1674	c.1486C>A	c.(1486-1488)CGG>AGG	p.R496R	FAM126B_uc002uwu.2_Silent_p.R470R|FAM126B_uc002uwv.2_Silent_p.R496R	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	496						intracellular				ovary(1)	1						TGACCTAGCCGGTCTTCCTGC	0.512													4	45					0.00024832	0.000373431	1	0	T	201846100	T	T	201846100	2	4	236	1	0	0	0	0	0	0	0	1	5458	1115	39	3		3	FAM126B	2	201846100	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3199625	201846100	41353273	81	42719											
ALS2CR4	65062	broad.mit.edu	37	chr2	202494493	202494493	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtgccacatctctggtggtCcaggaaggcttcacgtccat	8	10	11	12	1	2	0	1	0	1	0	5	1	4	1	3	4	1	1	3	4	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:202494493C>A	uc002uyh.1	-	9	737	c.636G>T	c.(634-636)TGG>TGT	p.W212C	ALS2CR4_uc002uyg.1_Missense_Mutation_p.W204C|ALS2CR4_uc010zho.1_Missense_Mutation_p.W7C|ALS2CR4_uc010zhp.1_RNA	NM_001044385	NP_001037850	Q96Q45	TM237_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	236						integral to membrane	protein binding				0						CTCTGGTGGTCCAGGAAGGCT	0.428													26	78					2.44723e-14	4.55148e-14	1	0	A	202494493	A	A	202494493	3	1	236	1	0	0	0	0	1	0	0	0	554	856	30	2	614	2	ALS2CR4	2	202494493	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	648393	202494493	40704880	82	42720											
PTH2R	5746	broad.mit.edu	37	chr2	209302279	209302279	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaaggtaattgtttccctGaatgggatggactcatttgt	10	15	11	5	0	1	2	1	1	0	1	2	4	2	4	1	3	0	2	1	3	4	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:209302279G>T	uc002vdb.2	+	3	409	c.196G>T	c.(196-198)GAA>TAA	p.E66*	PTH2R_uc010zjb.1_Nonsense_Mutation_p.E77*	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	66	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TTGTTTCCCTGAATGGGATGG	0.343													23	26					7.87624e-14	1.45385e-13	1	0	T	209302279	T	T	209302279	4	4	236	1	0	0	0	0	0	1	0	0	12823	1291	45	2	206	2	PTH2R	2	209302279	Nonsense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	6807786	209302279	33897094	83	42721											
VWC2L	402117	broad.mit.edu	37	chr2	215301351	215301351	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctaattttagatttgttcctAgccctctccatgtgaatggt	8	17	7	9	0	1	2	0	1	1	1	3	2	2	2	3	1	1	1	3	1	4	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:215301351A>T	uc002vet.2	+	3	521	c.391_splice	c.e3-2	p.P131_splice	VWC2L_uc010zjl.1_Intron	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing							extracellular region					0						ATTTGTTCCTAGCCCTCTCCA	0.428													33	24					0	0	0	0	T	215301351	T	T	215301351	5	4	236	1	0	0	0	0	0	0	1	0	17312	434	15	5	395	5	VWC2L	2	215301351	Splice_Site	SNP	A	TCGA-CV-7245-01A-11D-2012-08	5999072	215301351	27898022	84	42722											
CXCR1	3577	broad.mit.edu	37	chr2	219029140	219029140	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgggtcctcatgagggtGtctgccagcaggaccaggtt	7	9	14	11	0	2	1	1	1	1	0	3	2	3	2	4	4	2	2	4	4	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:219029140G>T	uc002vhc.2	-	2	914	c.795C>A	c.(793-795)GAC>GAA	p.D265E		NM_000634	NP_000625	P25024	CXCR1_HUMAN	interleukin 8 receptor alpha	265	Extracellular (Potential).				dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			lung(2)	2						TCATGAGGGTGTCTGCCAGCA	0.592													31	98					1.75199e-13	3.20979e-13	1	0	T	219029140	T	T	219029140	3	4	236	1	0	0	0	0	1	0	0	0	4107	1368	48	4	261	4	CXCR1	2	219029140	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3727789	219029140	24170233	85	42723											
RHBDD1	84236	broad.mit.edu	37	chr2	227731999	227731999	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccgaacagatttgcttgttgGgtcgaacttgtggctattca	8	14	11	8	2	1	1	1	0	0	1	2	3	1	1	1	2	3	3	1	2	3	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:227731999G>T	uc002voi.2	+	3	652	c.531G>T	c.(529-531)TGG>TGT	p.W177C	RHBDD1_uc010fxc.2_Missense_Mutation_p.W177C	NM_032276	NP_115652	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	177						integral to membrane	serine-type endopeptidase activity			ovary(1)	1		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		TTGCTTGTTGGGTCGAACTTG	0.398													80	79					9.11151e-29	1.88369e-28	1	0	T	227731999	T	T	227731999	3	4	236	1	0	0	0	0	1	0	0	0	13381	1241	43	4	537	4	RHBDD1	2	227731999	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	8702859	227731999	15467374	86	42724											
ALPP	250	broad.mit.edu	37	chr2	233244620	233244620	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgccaggacatcgctacgCagctcatctccaacatggac	10	7	10	14	2	2	0	1	0	1	0	4	2	2	2	2	3	4	3	2	3	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:233244620C>A	uc002vsq.2	+	5	796	c.631C>A	c.(631-633)CAG>AAG	p.Q211K	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	211						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		CATCGCTACGCAGCTCATCTC	0.672													16	85					4.96729e-08	8.23966e-08	1	0	A	233244620	A	A	233244620	3	1	236	1	0	0	0	0	1	0	0	0	548	711	25	4	649	4	ALPP	2	233244620	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5512621	233244620	9954753	87	42725											
ALPPL2	251	broad.mit.edu	37	chr2	233272622	233272622	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagccggcgcctacgcccaCacggtgaaccgcaactggta	9	4	11	17	5	0	1	0	1	0	0	0	1	0	1	5	3	4	2	5	3	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:233272622C>A	uc002vss.3	+	5	596	c.543C>A	c.(541-543)CAC>CAA	p.H181Q		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	181					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CCTACGCCCACACGGTGAACC	0.627													25	91					9.57634e-11	1.67629e-10	1	0	A	233272622	A	A	233272622	3	1	236	1	0	0	0	0	1	0	0	0	549	477	17	4	561	4	ALPPL2	2	233272622	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	28002	233272622	9926751	88	42726											
INPP5D	3635	broad.mit.edu	37	chr2	234112790	234112790	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcccagtgacctggggaaGaacgcaggggacacgctgcc	10	3	16	12	2	0	2	0	1	0	1	0	4	0	4	3	5	2	2	3	5	2	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:234112790G>C	uc010zmo.1	+	25	3147	c.2994G>C	c.(2992-2994)AAG>AAC	p.K998N	INPP5D_uc010zmp.1_Missense_Mutation_p.K997N	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	998	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		ACCTGGGGAAGAACGCAGGGG	0.473													4	11					0	0	0	0	C	234112790	C	C	234112790	3	2	236	1	0	0	0	0	1	0	0	0	7795	933	33	2	2604	2	INPP5D	2	234112790	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	840168	234112790	9086583	89	42727											
TRPM8	79054	broad.mit.edu	37	chr2	234862641	234862641	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgaaattgtgagcaatgcCatctcctacgctctatacaa	13	11	7	10	1	2	2	0	2	2	0	3	3	2	2	2	0	4	2	2	0	6	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:234862641C>T	uc002vvh.2	+	10	1261	c.1221C>T	c.(1219-1221)GCC>GCT	p.A407A	TRPM8_uc010fyj.2_Silent_p.A95A	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	407	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TGAGCAATGCCATCTCCTACG	0.368													24	8					0	0	0	0	T	234862641	T	T	234862641	2	4	236	1	0	0	0	0	0	0	0	1	16659	581	21	4		4	TRPM8	2	234862641	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	749851	234862641	8336732	90	42728											
ING5	84289	broad.mit.edu	37	chr2	242648716	242648716	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaccagcgcgtggagcgcctGcagaagatccagaacgccta	11	4	13	13	4	0	3	0	0	0	3	1	5	1	4	4	1	4	1	4	1	3	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr2:242648716G>T	uc002wcd.2	+	3	220	c.195G>T	c.(193-195)CTG>CTT	p.L65L	ING5_uc002wcc.1_Silent_p.L65L	NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	65					DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		TGGAGCGCCTGCAGAAGATCC	0.567													58	206					4.1673e-28	8.56128e-28	1	0	T	242648716	T	T	242648716	2	4	236	1	0	0	0	0	0	0	0	1	7778	1306	46	4		4	ING5	2	242648716	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	7786075	242648716	550657	91	42729											
CHL1	10752	broad.mit.edu	37	chr3	367721	367721	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtattttcaaattgaatgTgaagctaaaggaaatccaga	17	11	9	4	0	1	3	1	2	0	1	2	5	2	4	1	1	1	2	1	1	7	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:367721T>A	uc003bou.2	+	4	442	c.171T>A	c.(169-171)TGT>TGA	p.C57*	CHL1_uc003bot.2_Nonsense_Mutation_p.C57*|CHL1_uc003bow.1_Nonsense_Mutation_p.C57*|CHL1_uc011asi.1_Nonsense_Mutation_p.C57*	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	57	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AAATTGAATGTGAAGCTAAAG	0.348													18	16					0	0	0	0	A	367721	A	A	367721	4	1	236	1	0	0	0	0	0	1	0	0	3364	1702	59	5	177	5	CHL1	3	367721	Nonsense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08		367721	197654709	92	42730											
CHL1	10752	broad.mit.edu	37	chr3	433478	433478	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctatcttttgcaatatcagaTaagtaagtagaaatttgaat	16	15	6	4	0	2	3	1	1	1	2	2	3	2	3	0	0	1	3	0	0	8	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:433478T>A	uc003bou.2	+	22	3135	c.2864T>A	c.(2863-2865)ATA>AAA	p.I955K	CHL1_uc003bot.2_Missense_Mutation_p.I971K|CHL1_uc003bow.1_Missense_Mutation_p.I955K|CHL1_uc011asi.1_Missense_Mutation_p.I971K	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	955	Fibronectin type-III 4.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAATATCAGATAAGTAAGTAG	0.333													9	24					0	0	0	0	A	433478	A	A	433478	3	1	236	1	0	0	0	0	1	0	0	0	3364	1406	49	5	2994	5	CHL1	3	433478	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	65757	433478	197588952	93	42731											
LRRN1	57633	broad.mit.edu	37	chr3	3886778	3886778	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cttcaagaactctacatcaaCcacaaccaaattagcactat	17	9	2	13	0	3	1	2	0	1	1	3	1	3	1	2	0	5	1	2	0	8	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:3886778C>G	uc003bpt.3	+	2	1214	c.453C>G	c.(451-453)AAC>AAG	p.N151K	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	151	LRR 4.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TCTACATCAACCACAACCAAA	0.398													10	29					0	0	0	0	G	3886778	G	G	3886778	3	3	236	1	0	0	0	0	1	0	0	0	9084	506	18	4	455	4	LRRN1	3	3886778	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3453300	3886778	194135652	94	42732											
SLC6A11	6538	broad.mit.edu	37	chr3	10960130	10960130	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtacccattgctgaggtggCagagtcaggtaagttcgcca	9	9	14	9	1	1	2	1	1	0	1	2	2	1	2	2	4	2	5	2	4	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:10960130C>T	uc003bvz.2	+	8	1146	c.1112C>T	c.(1111-1113)GCA>GTA	p.A371V		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	371					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		GCTGAGGTGGCAGAGTCAGGT	0.567													17	8					0	0	0	0	T	10960130	T	T	10960130	3	4	236	1	0	0	0	0	1	0	0	0	14738	710	25	4	1142	4	SLC6A11	3	10960130	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	7073352	10960130	187062300	95	42733											
KCNH8	131096	broad.mit.edu	37	chr3	19554594	19554594	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacaaggggatcttcttcgCgcaacaagaaggttggaagc	12	7	13	9	2	2	1	0	0	2	1	3	3	2	3	0	4	2	3	0	4	5	3	rs138619397		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:19554594C>T	uc003cbk.1	+	13	2407	c.2212C>T	c.(2212-2214)CGC>TGC	p.R738C	KCNH8_uc010hex.1_Missense_Mutation_p.R199C	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	738	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity	p.R738L(1)		lung(4)|ovary(1)	5						ATCTTCTTCGCGCAACAAGAA	0.428													15	48					0	0	0	0	T	19554594	T	T	19554594	3	4	236	1	0	0	0	0	1	0	0	0	8077	768	27	1	2262	1	KCNH8	3	19554594	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	8594464	19554594	178467836	96	42734											
ZCWPW2	152098	broad.mit.edu	37	chr3	28562532	28562532	+	Frame_Shift_Del	DEL	G	-	-																															gagctggagcaaatgctgcaGcaagcactgcaacccacagc																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:28562532delG	uc003ceh.2	+	9	1002	c.834delG	c.(832-834)CAGfs	p.Q278fs	ZCWPW2_uc003cei.2_Frame_Shift_Del_p.Q278fs|ZCWPW2_uc010hfo.2_Frame_Shift_Del_p.Q83fs	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	278							zinc ion binding			ovary(2)	2						AAATGCTGCAGCAAGCACTGC	0.373													---	---	---								-	28562532	-	-	28562532	7	5	236	1	0	1	0	1	0	0	0	0	17665	962	34	0	860	0	ZCWPW2	3	28562532	Frame_Shift_Del	DEL	G	TCGA-CV-7245-01A-11D-2012-08	9007938	28562532	169459898	97	42735											
TRIM71	131405	broad.mit.edu	37	chr3	32932010	32932010	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggcccgagaccggatgctGgcccaggtgcaggagctgaa	8	5	16	12	2	0	2	0	1	0	1	0	5	0	4	3	5	3	3	3	5	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:32932010G>T	uc003cff.2	+	4	1377	c.1314G>T	c.(1312-1314)CTG>CTT	p.L438L		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	438					multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						ACCGGATGCTGGCCCAGGTGC	0.617													47	22					3.76604e-16	7.18106e-16	1	0	T	32932010	T	T	32932010	2	4	236	1	0	0	0	0	0	0	0	1	16611	1335	47	4		4	TRIM71	3	32932010	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4369478	32932010	165090420	98	42736											
SCN10A	6336	broad.mit.edu	37	chr3	38793848	38793848	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggccagcacccccaccCagcagcagagagccccgatg	9	3	11	18	1	0	1	0	0	0	1	0	3	0	1	6	1	5	4	6	1	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:38793848C>G	uc003ciq.2	-	11	1617	c.1617G>C	c.(1615-1617)CTG>CTC	p.L539L		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	539					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CACCCCCACCCAGCAGCAGAG	0.607													24	20					0	0	0	0	G	38793848	G	G	38793848	2	3	236	1	0	0	0	0	0	0	0	1	13977	581	21	4		4	SCN10A	3	38793848	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5861838	38793848	159228582	99	42737											
TGM4	7047	broad.mit.edu	37	chr3	44952882	44952882	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctgggcatctcctcactaCagacctctgaccatgggtga	8	9	10	14	0	3	3	1	2	2	1	4	3	3	3	4	2	1	1	4	2	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:44952882C>A	uc003coc.3	+	13	1970	c.1897C>A	c.(1897-1899)CAG>AAG	p.Q633K		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	633					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	CTCCTCACTACAGACCTCTGA	0.363													29	69					1.80694e-10	3.14613e-10	1	0	A	44952882	A	A	44952882	3	1	236	1	0	0	0	0	1	0	0	0	15898	479	17	4	1947	4	TGM4	3	44952882	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	6159034	44952882	153069548	100	42738											
GLYCTK	132158	broad.mit.edu	37	chr3	52325847	52325847	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactagactgctggcagcccGtggagccaccatccaggagt	9	6	12	14	1	0	1	0	0	0	1	1	3	1	3	4	3	3	2	4	3	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:52325847G>T	uc003ddo.2	+	4	710	c.614G>T	c.(613-615)CGT>CTT	p.R205L	GLYCTK_uc003ddq.2_Intron|GLYCTK_uc003ddm.2_RNA|GLYCTK_uc003ddn.2_Intron|GLYCTK_uc003ddp.1_Missense_Mutation_p.R205L|GLYCTK_uc003ddr.2_5'Flank	NM_145262	NP_660305	Q8IVS8	GLCTK_HUMAN	glycerate kinase isoform 1	205					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		CTGGCAGCCCGTGGAGCCACC	0.622											OREG0015611	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	41					2.42023e-17	4.66013e-17	1	0	T	52325847	T	T	52325847	3	4	236	1	0	0	0	0	1	0	0	0	6519	1145	40	3	624	3	GLYCTK	3	52325847	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	7372965	52325847	145696583	101	42739											
ZPLD1	131368	broad.mit.edu	37	chr3	102196426	102196426	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggaagggacccacaagtttAgtgttgaatggcataagaaa	16	8	12	5	0	0	2	0	1	0	1	0	4	0	4	1	3	0	3	1	3	6	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:102196426A>G	uc003dvs.1	+	18	2094	c.1212A>G	c.(1210-1212)TTA>TTG	p.L404L	ZPLD1_uc003dvt.1_Silent_p.L420L|ZPLD1_uc011bhg.1_Silent_p.L404L	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	404	Cytoplasmic (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						CCACAAGTTTAGTGTTGAATG	0.473													38	112					0	0	0	0	G	102196426	G	G	102196426	2	3	236	1	0	0	0	0	0	0	0	1	18288	417	15	5		5	ZPLD1	3	102196426	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	49870579	102196426	95826004	102	42740											
PVRL3	25945	broad.mit.edu	37	chr3	110837676	110837676	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttttccaaatgaaacggcaAcgattatcagccagtacaag	15	9	7	10	2	1	1	1	1	0	0	2	2	2	1	2	1	4	2	2	1	6	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:110837676A>G	uc003dxt.1	+	3	676	c.676A>G	c.(676-678)ACG>GCG	p.T226A	PVRL3_uc003dxu.1_Missense_Mutation_p.T203A	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	226	Extracellular (Potential).|Ig-like C2-type 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						TGAAACGGCAACGATTATCAG	0.433													10	58					0	0	0	0	G	110837676	G	G	110837676	3	3	236	1	0	0	0	0	1	0	0	0	12906	43	2	5	686	5	PVRL3	3	110837676	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	8641250	110837676	87184754	103	42741											
PVRL3	25945	broad.mit.edu	37	chr3	110837725	110837725	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccagatttgctagaggaaGgcgaattacttgtgttgtaa	13	12	11	5	1	0	2	0	0	0	2	0	4	0	3	1	2	3	3	1	2	6	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:110837725G>T	uc003dxt.1	+	3	725	c.725G>T	c.(724-726)AGG>ATG	p.R242M	PVRL3_uc003dxu.1_Missense_Mutation_p.R219M	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	242	Extracellular (Potential).|Ig-like C2-type 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						GCTAGAGGAAGGCGAATTACT	0.373													14	59					7.93312e-07	1.2771e-06	1	0	T	110837725	T	T	110837725	3	4	236	1	0	0	0	0	1	0	0	0	12906	1000	35	4	735	4	PVRL3	3	110837725	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	49	110837725	87184705	104	42742											
KIAA1407	57577	broad.mit.edu	37	chr3	113724674	113724674	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggtcttgtgctgcttatTgccaggtgcactcagagaga	8	11	13	9	0	2	2	1	0	1	2	2	3	2	2	1	2	4	3	1	2	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:113724674T>G	uc003eax.2	-	10	1696	c.1549A>C	c.(1549-1551)AAT>CAT	p.N517H	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.N495H|KIAA1407_uc011bip.1_Missense_Mutation_p.N504H	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	517										ovary(2)	2						TGCTGCTTATTGCCAGGTGCA	0.542													46	217					0	0	0	0	G	113724674	G	G	113724674	3	3	236	1	0	0	0	0	1	0	0	0	8268	1812	63	5	1293	5	KIAA1407	3	113724674	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2886949	113724674	84297756	105	42743											
LSAMP	4045	broad.mit.edu	37	chr3	115560725	115560725	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggcattggtgacccccaGcttgttggcagccacacagg	7	8	13	13	0	0	1	0	1	0	0	0	1	0	1	3	4	2	5	3	4	0	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:115560725G>C	uc003ebt.2	-	6	1386	c.886C>G	c.(886-888)CTG>GTG	p.L296V	LSAMP_uc011bis.1_Missense_Mutation_p.L296V	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	296	Ig-like C2-type 3.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GTGACCCCCAGCTTGTTGGCA	0.502													12	91					0	0	0	0	C	115560725	C	C	115560725	3	2	236	1	0	0	0	0	1	0	0	0	9098	962	34	4	138	4	LSAMP	3	115560725	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1836051	115560725	82461705	106	42744											
C3orf1	51300	broad.mit.edu	37	chr3	119236160	119236160	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgagctaaaactggaagaGtggtaaggaacatgttgagc	15	8	13	5	0	0	3	0	2	0	1	0	5	0	5	0	3	4	3	0	3	5	3	rs150396264	byFrequency	TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:119236160G>A	uc003ecn.2	+	6	918	c.705G>A	c.(703-705)GAG>GAA	p.E235E	C3orf1_uc003eco.2_RNA|C3orf1_uc003ecp.2_RNA	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300	235						integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		AACTGGAAGAGTGGTAAGGAA	0.458													90	73					0	0	0	0	A	119236160	A	A	119236160	2	1	236	1	0	0	0	0	0	0	0	1	2216	1020	36	4		4	C3orf1	3	119236160	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3675435	119236160	78786270	107	42745											
MYLK	4638	broad.mit.edu	37	chr3	123471326	123471326	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccagcaggaagcggcccccGctggtgatgggttgcccgtt	5	8	15	13	3	0	1	0	1	0	0	1	2	1	2	4	4	3	4	4	4	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:123471326G>T	uc003ego.2	-	5	507	c.225C>A	c.(223-225)AGC>AGA	p.S75R	MYLK_uc011bjw.1_Missense_Mutation_p.S75R|MYLK_uc003egp.2_Missense_Mutation_p.S75R|MYLK_uc003egq.2_Missense_Mutation_p.S75R|MYLK_uc003egr.2_Missense_Mutation_p.S75R|MYLK_uc003egs.2_Intron|MYLK_uc010hrs.1_Missense_Mutation_p.S75R|MYLK_uc003egu.1_Missense_Mutation_p.S85R	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	75	Ig-like C2-type 1.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		AGCGGCCCCCGCTGGTGATGG	0.517													24	28					5.45024e-15	1.02926e-14	1	0	T	123471326	T	T	123471326	3	4	236	1	0	0	0	0	1	0	0	0	10109	1078	38	3	5639	3	MYLK	3	123471326	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4235166	123471326	74551104	108	42746											
RAB7A	7879	broad.mit.edu	37	chr3	128514247	128514247	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgttgctgaaggttatcAtcctgggagattctgggtaa	10	13	13	5	0	2	2	1	1	1	1	3	3	3	2	1	3	1	4	1	3	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:128514247A>T	uc003eks.1	+	2	269	c.37A>T	c.(37-39)ATC>TTC	p.I13F	RAB7A_uc010hsv.1_Missense_Mutation_p.I13F|RAB7A_uc003ekt.2_5'Flank	NM_004637	NP_004628	P51149	RAB7A_HUMAN	RAB7, member RAS oncogene family	13					endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding				0				GBM - Glioblastoma multiforme(114;0.231)		GAAGGTTATCATCCTGGGAGA	0.458											OREG0015781	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	48					0	0	0	0	T	128514247	T	T	128514247	3	4	236	1	0	0	0	0	1	0	0	0	13019	217	8	5	39	5	RAB7A	3	128514247	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	5042921	128514247	69508183	109	42747											
DZIP1L	199221	broad.mit.edu	37	chr3	137803000	137803000	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctagcttgttcctgcagctgGgcacggagggtgctgatctg	5	11	15	10	1	1	1	0	1	1	0	2	2	2	2	1	3	4	6	1	3	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:137803000G>A	uc003erq.2	-	8	1521	c.1158C>T	c.(1156-1158)GCC>GCT	p.A386A	DZIP1L_uc003err.1_Silent_p.A386A	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	386	Potential.					intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						CCTGCAGCTGGGCACGGAGGG	0.607													25	132					0	0	0	0	A	137803000	A	A	137803000	2	1	236	1	0	0	0	0	0	0	0	1	4886	1219	43	4		4	DZIP1L	3	137803000	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	9288753	137803000	60219430	110	42748											
FAM194A	131831	broad.mit.edu	37	chr3	150421899	150421900	+	5'Flank	INS	-	C	C																															cagacttctttctgtccctgINSctcttcagcgtctctgaaac																								rs148177227	by1000genomes	TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:150421899_150421900insC	uc003eyg.2	-						FAM194A_uc003eyh.2_5'Flank	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831											skin(2)|ovary(1)	3						TTCTGTCCCTGCTCTTCAGCGT	0.545													---	---	---								C	150421900	C	C	150421899	6	5	236	0	1	1	1	0	0	0	0	0	5554	1334	46	0		0	FAM194A	3	150421899	5'Flank	INS	-	TCGA-CV-7245-01A-11D-2012-08	12618899	150421899	47600531	111	42749											
SSR3	6747	broad.mit.edu	37	chr3	156272987	156272987	+	5'Flank	DEL	G	-	-																															cgctaacgacccgtcagcgcGgcgcgcggaggcgggacccg																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:156272987delG	uc003fau.2	-						SSR3_uc011bop.1_5'Flank	NM_007107	NP_009038	Q9UNL2	SSRG_HUMAN	signal sequence receptor gamma subunit						cotranslational protein targeting to membrane	integral to endoplasmic reticulum membrane|microsome|Sec61 translocon complex	protein binding|signal sequence binding				0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CCGTCAGCGCGGCGCGCGGAG	0.697													---	---	---								-	156272987	-	-	156272987	6	5	236	0	1	1	0	1	0	0	0	0	15258	1131	39	0		0	SSR3	3	156272987	5'Flank	DEL	G	TCGA-CV-7245-01A-11D-2012-08	5851088	156272987	41749443	112	42750											
VEPH1	79674	broad.mit.edu	37	chr3	157082158	157082158	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gactatatcttctgatagagCcaggggtattgctccctgca	9	12	10	10	0	2	2	0	1	2	1	3	3	3	2	2	2	3	3	2	2	4	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:157082158C>A	uc003fbj.1	-	8	1588	c.1271G>T	c.(1270-1272)GGC>GTC	p.G424V	VEPH1_uc003fbk.1_Missense_Mutation_p.G424V|VEPH1_uc010hvu.1_Missense_Mutation_p.G424V	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	424						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TCTGATAGAGCCAGGGGTATT	0.348													22	106					7.45023e-12	1.3206e-11	1	0	A	157082158	A	A	157082158	3	1	236	1	0	0	0	0	1	0	0	0	17222	739	26	4	1258	4	VEPH1	3	157082158	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	809171	157082158	40940272	113	42751											
SHOX2	6474	broad.mit.edu	37	chr3	157823782	157823782	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcactttctggtcaaaaGacttggagacgaacgccgta	11	10	9	11	3	3	2	2	0	1	2	3	4	3	2	2	2	1	1	2	2	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:157823782G>T	uc003fbr.2	-	1	171	c.32C>A	c.(31-33)TCT>TAT	p.S11Y	SHOX2_uc003fbs.2_Missense_Mutation_p.S11Y|SHOX2_uc010hvw.2_Missense_Mutation_p.S11Y	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	11					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CTGGTCAAAAGACTTGGAGAC	0.617													15	62					1.3612e-06	2.1735e-06	1	0	T	157823782	T	T	157823782	3	4	236	1	0	0	0	0	1	0	0	0	14354	942	33	2	1059	2	SHOX2	3	157823782	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	741624	157823782	40198648	114	42752											
SCHIP1	29970	broad.mit.edu	37	chr3	158980399	158980399	+	Frame_Shift_Del	DEL	C	-	-																															cctggggaagaggagcccgtCcccaccctctgtctcctcag																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:158980399delC	uc003fcq.1	+	4	323	c.218delC	c.(217-219)TCCfs	p.S73fs	SCHIP1_uc003fcr.1_5'UTR|IQCJ_uc003fco.2_Frame_Shift_Del_p.S73fs|IQCJ_uc010hvy.1_Frame_Shift_Del_p.S46fs|IQCJ_uc003fcp.1_Frame_Shift_Del_p.S73fs	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	Error:Variant_position_missing_in_Q9P0W5_after_alignment						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			AGGAGCCCGTCCCCACCCTCT	0.522													---	---	---								-	158980399	-	-	158980399	7	5	236	1	0	1	0	1	0	0	0	0	13969	855	30	0		0	SCHIP1	3	158980399	Frame_Shift_Del	DEL	C	TCGA-CV-7245-01A-11D-2012-08	1156617	158980399	39042031	115	42753											
WDR49	151790	broad.mit.edu	37	chr3	167196746	167196746	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatgatgcagaatttcctTgggaaacaggtttttctcat	10	16	8	7	0	2	2	2	1	1	1	4	3	3	3	1	2	2	2	1	2	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:167196746T>G	uc003fev.1	-	15	2320	c.2014A>C	c.(2014-2016)AAG>CAG	p.K672Q	WDR49_uc003feu.1_Missense_Mutation_p.K497Q|WDR49_uc011bpd.1_Missense_Mutation_p.K637Q|WDR49_uc003few.1_3'UTR	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	672										large_intestine(1)|ovary(1)|skin(1)	3						AGAATTTCCTTGGGAAACAGG	0.308													22	46					0	0	0	0	G	167196746	G	G	167196746	3	3	236	1	0	0	0	0	1	0	0	0	17370	1821	63	5	83	5	WDR49	3	167196746	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	8216347	167196746	30825684	116	42754											
WDR49	151790	broad.mit.edu	37	chr3	167250747	167250747	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctattgttccatagaacaAtttctccatcataactccct	11	15	3	12	0	2	1	1	0	1	1	5	1	4	1	3	0	3	2	3	0	5	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:167250747A>T	uc003fev.1	-	8	1223	c.917T>A	c.(916-918)ATT>AAT	p.I306N	WDR49_uc003feu.1_Missense_Mutation_p.I131N|WDR49_uc011bpd.1_Missense_Mutation_p.I370N|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	306	WD 5.									large_intestine(1)|ovary(1)|skin(1)	3						CCATAGAACAATTTCTCCATC	0.373													12	54					0	0	0	0	T	167250747	T	T	167250747	3	4	236	1	0	0	0	0	1	0	0	0	17370	101	4	5	1208	5	WDR49	3	167250747	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	54001	167250747	30771683	117	42755											
LRRC34	151827	broad.mit.edu	37	chr3	169514002	169514002	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaatataaaaccatactaacGctttaagactcctgttgtgt	15	13	5	8	1	0	1	0	0	0	1	1	1	1	1	2	0	3	2	2	0	7	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:169514002G>C	uc003ffx.2	-	8	944	c.929C>G	c.(928-930)GCG>GGG	p.A310G	LRRC34_uc003ffy.2_Missense_Mutation_p.A342G|LRRC34_uc011bpn.1_Missense_Mutation_p.A342G|LRRC34_uc003ffz.2_Missense_Mutation_p.A294G|LRRC34_uc003fga.3_Missense_Mutation_p.A294G	NM_153353	NP_699184	Q8IZ02	LRC34_HUMAN	leucine rich repeat containing 34	310											0	all_cancers(22;4.12e-22)|all_epithelial(15;7.54e-27)|all_lung(20;1.63e-16)|Lung NSC(18;6.92e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			CCATACTAACGCTTTAAGACT	0.303													46	50					0	0	0	0	C	169514002	C	C	169514002	3	2	236	1	0	0	0	0	1	0	0	0	9039	1101	38	3	364	3	LRRC34	3	169514002	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2263255	169514002	28508428	118	42756											
TNIK	23043	broad.mit.edu	37	chr3	170789099	170789099	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcaatcaccaaaaatttgatCctttcatatttaactgtaat	15	15	3	8	0	2	1	2	1	0	0	3	1	3	1	2	0	1	2	2	0	6	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:170789099C>T	uc003fhh.2	-	29	3807	c.3462G>A	c.(3460-3462)AGG>AGA	p.R1154R	TNIK_uc003fhi.2_Silent_p.R1099R|TNIK_uc003fhj.2_Silent_p.R1125R|TNIK_uc003fhk.2_Silent_p.R1146R|TNIK_uc003fhl.2_Silent_p.R1070R|TNIK_uc003fhm.2_Silent_p.R1091R|TNIK_uc003fhn.2_Silent_p.R1117R|TNIK_uc003fho.2_Silent_p.R1062R|TNIK_uc003fhg.2_Silent_p.R332R|TNIK_uc003fhp.2_Silent_p.R86R	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1154	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			AAAATTTGATCCTTTCATATT	0.294													11	17					0	0	0	0	T	170789099	T	T	170789099	2	4	236	1	0	0	0	0	0	0	0	1	16379	854	30	2		2	TNIK	3	170789099	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1275097	170789099	27233331	119	42757											
SPATA16	83893	broad.mit.edu	37	chr3	172835472	172835472	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttggaacaagctgatcatgaTagatcctattcactgcattc	12	13	7	9	0	2	3	2	2	0	1	4	4	3	4	1	1	3	2	1	1	4	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:172835472T>C	uc003fin.3	-	2	208	c.50A>G	c.(49-51)TAT>TGT	p.Y17C		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	17					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			CTGATCATGATAGATCCTATT	0.433													104	160					0	0	0	0	C	172835472	C	C	172835472	3	2	236	1	0	0	0	0	1	0	0	0	15067	1406	49	5	1699	5	SPATA16	3	172835472	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2046373	172835472	25186958	120	42758											
MFN1	55669	broad.mit.edu	37	chr3	179107824	179107824	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttttgctcgcctgtgccAacaagttgatattactcaaa	11	13	6	11	1	1	1	1	1	0	0	2	1	1	1	2	0	4	2	2	0	5	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:179107824A>T	uc003fjs.2	+	17	2171	c.2045A>T	c.(2044-2046)CAA>CTA	p.Q682L	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.Q710L|MFN1_uc010hxc.2_Missense_Mutation_p.Q424L	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	682	Cytoplasmic (Potential).|Potential.				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CGCCTGTGCCAACAAGTTGAT	0.308													15	80					0	0	0	0	T	179107824	T	T	179107824	3	4	236	1	0	0	0	0	1	0	0	0	9576	130	5	5	2107	5	MFN1	3	179107824	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	6272352	179107824	18914606	121	42759											
EIF2B5	8893	broad.mit.edu	37	chr3	183855540	183855540	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgctctgactttcttctggtGtatggggatgtcatctcaaa	7	15	10	9	1	5	1	2	1	4	0	6	2	5	2	0	3	0	2	0	3	2	3	rs113994052		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:183855540G>A	uc003fmp.2	+	3	817	c.453G>A	c.(451-453)GTG>GTA	p.V151V	EIF2B5_uc003fmq.2_5'UTR	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,	151					astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TTCTTCTGGTGTATGGGGATG	0.473													53	95					0	0	0	0	A	183855540	A	A	183855540	2	1	236	1	0	0	0	0	0	0	0	1	5026	1364	48	4		4	EIF2B5	3	183855540	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4747716	183855540	14166890	122	42760											
UTS2D	257313	broad.mit.edu	37	chr3	190995894	190995894	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctttggaaatcaaaattttTattcagtagagccagcaata	15	14	6	6	0	3	1	2	0	1	1	3	2	3	2	1	1	2	2	1	1	7	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:190995894T>C	uc003fsu.2	-	6	956	c.169A>G	c.(169-171)AAA>GAA	p.K57E		NM_198152	NP_937795	Q765I0	UTS2B_HUMAN	urotensin 2 domain containing precursor	57						extracellular region	hormone activity				0	all_cancers(143;1.77e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000214)		TCAAAATTTTTATTCAGTAGA	0.279													17	15					0	0	0	0	C	190995894	C	C	190995894	3	2	236	1	0	0	0	0	1	0	0	0	17173	1763	61	5	206	5	UTS2D	3	190995894	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	7140354	190995894	7026536	123	42761											
TFRC	7037	broad.mit.edu	37	chr3	195782076	195782076	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacgaactgaccagcgacctCtgcagctgctcgtgccactt	8	8	9	16	3	1	1	0	1	1	0	2	3	1	1	3	0	6	3	3	0	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:195782076C>T	uc003fvz.3	-	17	2057	c.1774G>A	c.(1774-1776)GAG>AAG	p.E592K	TFRC_uc003fwa.3_Missense_Mutation_p.E592K|TFRC_uc010hzy.2_Missense_Mutation_p.E511K|TFRC_uc011btr.1_Missense_Mutation_p.E310K	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	592	Extracellular (Potential).|Ligand-binding.				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		CCAGCGACCTCTGCAGCTGCT	0.458			T	BCL6	NHL								45	200					0	0	0	0	T	195782076	T	T	195782076	3	4	236	1	0	0	0	0	1	0	0	0	15878	922	32	2	520	2	TFRC	3	195782076	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4786182	195782076	2240354	124	42762											
UBXN7	26043	broad.mit.edu	37	chr3	196096339	196096339	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggggaaatcccctaacttaTaaaactgtatgtatctctga	14	12	7	8	0	1	1	0	1	1	0	3	2	2	2	2	2	2	2	2	2	7	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:196096339T>C	uc003fwm.3	-	7	734	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	UBXN7_uc003fwn.3_Missense_Mutation_p.Y72C|UBXN7_uc010iae.2_Missense_Mutation_p.Y58C	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	220							protein binding			ovary(2)|pancreas(1)	3						CCCTAACTTATAAAACTGTAT	0.353													15	65					0	0	0	0	C	196096339	C	C	196096339	3	2	236	1	0	0	0	0	1	0	0	0	16986	1406	49	5	830	5	UBXN7	3	196096339	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	314263	196096339	1926091	125	42763											
LRRC33	375387	broad.mit.edu	37	chr3	196388450	196388450	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggactgcaagtgggagcggCtggacctgggcctgctctac	6	7	17	11	1	1	0	0	0	1	0	1	3	1	3	2	5	4	3	2	5	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr3:196388450C>A	uc003fwv.2	+	3	2040	c.1936C>A	c.(1936-1938)CTG>ATG	p.L646M		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	646	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		GTGGGAGCGGCTGGACCTGGG	0.637													53	167					4.25531e-23	8.56295e-23	1	0	A	196388450	A	A	196388450	3	1	236	1	0	0	0	0	1	0	0	0	9038	796	28	4	1942	4	LRRC33	3	196388450	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	292111	196388450	1633980	126	42764											
ZNF518B	85460	broad.mit.edu	37	chr4	10445495	10445495	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taaaggctgtaagtctgagtCcgcctgtctcacagggcaaa	11	9	11	10	1	2	1	1	1	2	0	4	1	3	1	2	2	0	3	2	2	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:10445495C>A	uc003gmn.2	-	3	2945	c.2458G>T	c.(2458-2460)GAC>TAC	p.D820Y		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	820					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						AAGTCTGAGTCCGCCTGTCTC	0.468													21	58					2.21704e-12	3.98013e-12	1	0	A	10445495	A	A	10445495	3	1	236	1	0	0	0	0	1	0	0	0	18030	855	30	2	770	2	ZNF518B	4	10445495	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08		10445495	180708781	127	42765											
LDB2	9079	broad.mit.edu	37	chr4	16513685	16513685	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaggttgtaagttttatGtctcgacatcagttcctgca	9	15	9	8	1	2	1	1	1	1	0	4	2	3	1	1	1	1	5	1	1	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:16513685G>A	uc003goz.2	-	6	974	c.658C>T	c.(658-660)CAT>TAT	p.H220Y	LDB2_uc003gpa.2_Missense_Mutation_p.H220Y|LDB2_uc003gpb.2_Missense_Mutation_p.H220Y|LDB2_uc011bxh.1_Missense_Mutation_p.H192Y|LDB2_uc010iee.2_Missense_Mutation_p.H220Y|LDB2_uc003goy.2_Missense_Mutation_p.H96Y|LDB2_uc011bxi.1_Missense_Mutation_p.H96Y	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	220							LIM domain binding|transcription cofactor activity				0						TAAGTTTTATGTCTCGACATC	0.443													16	24					0	0	0	0	A	16513685	A	A	16513685	3	1	236	1	0	0	0	0	1	0	0	0	8736	1377	48	4	584	4	LDB2	4	16513685	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	6068190	16513685	174640591	128	42766											
LCORL	254251	broad.mit.edu	37	chr4	18023432	18023444	+	5'Flank	DEL	GGCGCGAGCCCTC	-	-																															cagcgcaggcacgaggcaggGgcgcgagccctcggcgcgag																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	bdc58b10-1756-45bf-a34f-fa4095429476	g.chr4:18023432_18023444delGGCGCGAGCCCTC	uc003gpq.2	-						LCORL_uc011bxk.1_5'Flank	NM_153686	NP_710153	Q8N3X6	LCORL_HUMAN	ligand dependent nuclear receptor						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						ACGAGGCAGGGGCGCGAGCCCTCGGCGCGAGCC	0.629													---	---	---								-	18023444	-	-	18023432	6	5	236	0	1	1	0	1	0	0	0	0	8730	1247	43	0		0	LCORL	4	18023432	5'Flank	DEL	GGCGCGAGCCCTC	TCGA-CV-7245-01A-11D-2012-08	1509747	18023432	173130844	129	42767											
UGT2B7	7364	broad.mit.edu	37	chr4	69973976	69973976	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggggagcagctgttagagtgGacttcaacacaatgtcgagt	11	9	14	7	1	1	1	1	0	0	1	2	4	1	3	0	3	3	3	0	3	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:69973976G>A	uc003heg.3	+	5	1292	c.1246G>A	c.(1246-1248)GAC>AAC	p.D416N	UGT2B7_uc010ihq.2_Intron	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	416					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TGTTAGAGTGGACTTCAACAC	0.433													38	163					0	0	0	0	A	69973976	A	A	69973976	3	1	236	1	0	0	0	0	1	0	0	0	17030	1174	41	2	1264	2	UGT2B7	4	69973976	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	51950544	69973976	121180300	130	42768											
UGT2B4	7363	broad.mit.edu	37	chr4	70346550	70346550	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcgcatgacaaattcaatCcagaagactgctcgatcaag	14	8	9	10	2	2	3	2	1	0	2	4	4	3	3	1	1	1	2	1	1	4	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:70346550C>A	uc003hek.3	-	6	1436	c.1389G>T	c.(1387-1389)TGG>TGT	p.W463C	UGT2B4_uc011cap.1_Missense_Mutation_p.W327C|UGT2B4_uc003hel.3_3'UTR	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	463					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CAAATTCAATCCAGAAGACTG	0.448													74	131					6.72169e-28	1.37802e-27	1	0	A	70346550	A	A	70346550	3	1	236	1	0	0	0	0	1	0	0	0	17029	856	30	2	201	2	UGT2B4	4	70346550	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	372574	70346550	120807726	131	42769											
RCHY1	25898	broad.mit.edu	37	chr4	76415818	76415818	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatgttctgatattctgaTggcataggagtctgtgctac	8	15	11	7	0	4	2	1	2	3	0	4	3	4	3	0	2	2	3	0	2	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:76415818T>C	uc003hik.2	-	8	762	c.630A>G	c.(628-630)CCA>CCG	p.P210P	RCHY1_uc010iio.2_Silent_p.P106P|RCHY1_uc003hij.2_3'UTR|RCHY1_uc003hil.2_Silent_p.P201P|RCHY1_uc010iip.2_3'UTR|RCHY1_uc010iiq.2_RNA|RCHY1_uc010iir.2_Silent_p.P170P	NM_015436	NP_056251	Q96PM5	ZN363_HUMAN	ring finger and CHY zinc finger domain	210					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein autoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nuclear speck|ubiquitin ligase complex	electron carrier activity|p53 binding|protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			GATATTCTGATGGCATAGGAG	0.408													7	62					0	0	0	0	C	76415818	C	C	76415818	2	2	236	1	0	0	0	0	0	0	0	1	13242	1451	51	5		5	RCHY1	4	76415818	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	6069268	76415818	114738458	132	42770											
WDFY3	23001	broad.mit.edu	37	chr4	85654614	85654614	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catttcgcaccatctttttcCtcatcctgcagggcccttct	5	15	5	16	1	3	0	1	0	2	0	6	0	5	0	4	1	1	2	4	1	0	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:85654614C>G	uc003hpd.2	-	44	7550	c.7142G>C	c.(7141-7143)AGG>ACG	p.R2381T	WDFY3_uc003hpe.1_Missense_Mutation_p.R9T	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2381						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CATCTTTTTCCTCATCCTGCA	0.527													51	260					0	0	0	0	G	85654614	G	G	85654614	3	3	236	1	0	0	0	0	1	0	0	0	17338	681	24	4	3538	4	WDFY3	4	85654614	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	9238796	85654614	105499662	133	42771											
WDFY3	23001	broad.mit.edu	37	chr4	85657475	85657475	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgacttatgcatttcttttCatgggctattaaaaaatcaa	13	16	5	7	1	3	0	2	0	1	0	4	1	3	0	0	1	1	2	0	1	6	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:85657475C>A	uc003hpd.2	-	42	7171	c.6763G>T	c.(6763-6765)GAA>TAA	p.E2255*	WDFY3_uc003hpe.1_5'Flank	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2255						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CATTTCTTTTCATGGGCTATT	0.353													14	25					9.31168e-06	1.45375e-05	1	0	A	85657475	A	A	85657475	4	1	236	1	0	0	0	0	0	1	0	0	17338	835	29	2	3925	2	WDFY3	4	85657475	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2861	85657475	105496801	134	42772											
PTPN13	5783	broad.mit.edu	37	chr4	87728986	87728986	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcaacagacttcgactggCtcttgtgagaatgcagcagc	11	8	11	11	1	1	2	0	1	1	2	2	4	1	2	0	1	5	4	0	1	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:87728986C>G	uc003hpz.2	+	45	7499	c.7019C>G	c.(7018-7020)GCT>GGT	p.A2340G	PTPN13_uc003hpy.2_Missense_Mutation_p.A2345G|PTPN13_uc003hqa.2_Missense_Mutation_p.A2321G|PTPN13_uc003hqb.2_Missense_Mutation_p.A2149G	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2340	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CTTCGACTGGCTCTTGTGAGA	0.448													24	90					0	0	0	0	G	87728986	G	G	87728986	3	3	236	1	0	0	0	0	1	0	0	0	12845	797	28	4	7208	4	PTPN13	4	87728986	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2071511	87728986	103425290	135	42773											
UNC5C	8633	broad.mit.edu	37	chr4	96222797	96222797	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccggctctttgtggtaccCgcggagctccaggccacaca	6	9	11	15	3	1	0	0	0	1	0	3	1	3	1	4	4	2	3	4	4	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:96222797C>A	uc003htp.1	-	3	604	c.450G>T	c.(448-450)GCG>GCT	p.A150A	UNC5C_uc010ilc.1_Silent_p.A150A|UNC5C_uc003htq.2_Silent_p.A150A	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	150	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TTGTGGTACCCGCGGAGCTCC	0.502													26	24					0.000586117	0.000873394	1	0	A	96222797	A	A	96222797	2	1	236	1	0	0	0	0	0	0	0	1	17061	639	23	3		3	UNC5C	4	96222797	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	8493811	96222797	94931479	136	42774											
UNC5C	8633	broad.mit.edu	37	chr4	96469982	96469982	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcccagtccgcagcgggcCgctgtcgcccgcagaccttt	5	7	12	17	5	0	1	0	0	0	1	3	1	2	1	5	1	1	3	5	1	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:96469982C>T	uc003htp.1	-	1	181	c.27G>A	c.(25-27)GCG>GCA	p.A9A	UNC5C_uc010ilc.1_Silent_p.A9A|UNC5C_uc003htq.2_Silent_p.A9A	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	9					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CGCAGCGGGCCGCTGTCGCCC	0.667													60	49					0	0	0	0	T	96469982	T	T	96469982	2	4	236	1	0	0	0	0	0	0	0	1	17061	639	23	1		1	UNC5C	4	96469982	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	247185	96469982	94684294	137	42775											
ANK2	287	broad.mit.edu	37	chr4	114278239	114278239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcactcatgaaaaagacaCagagggagaagagcttgatg	17	5	13	6	0	1	6	1	2	0	4	1	7	1	6	0	2	1	2	0	2	3	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:114278239C>T	uc003ibe.3	+	38	8565	c.8465C>T	c.(8464-8466)ACA>ATA	p.T2822I	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.T124I|ANK2_uc011cgb.1_Missense_Mutation_p.T2837I	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2789					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAAAAAGACACAGAGGGAGAA	0.438													62	51					0	0	0	0	T	114278239	T	T	114278239	3	4	236	1	0	0	0	0	1	0	0	0	621	478	17	4	8680	4	ANK2	4	114278239	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	17808257	114278239	76876037	138	42776											
NDST3	9348	broad.mit.edu	37	chr4	118975167	118975167	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atttctgcttactacctgtaCagtggctacaaacaggaaaa	14	11	7	9	0	1	0	0	0	1	0	1	1	1	1	1	2	6	3	1	2	7	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:118975167C>T	uc003ibx.2	+	2	505	c.102C>T	c.(100-102)TAC>TAT	p.Y34Y	NDST3_uc011cgf.1_Silent_p.Y34Y|NDST3_uc003ibw.2_Silent_p.Y34Y	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	34	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						ACTACCTGTACAGTGGCTACA	0.413													23	94					0	0	0	0	T	118975167	T	T	118975167	2	4	236	1	0	0	0	0	0	0	0	1	10311	489	17	4		4	NDST3	4	118975167	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4696928	118975167	72179109	139	42777											
NDST3	9348	broad.mit.edu	37	chr4	118975575	118975575	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccacaaaactagtgagaaGagtgtacagagctttcagtt	14	11	9	7	0	1	3	1	1	0	3	2	4	2	3	1	0	3	3	1	0	5	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:118975575G>T	uc003ibx.2	+	2	913	c.510G>T	c.(508-510)AAG>AAT	p.K170N	NDST3_uc011cgf.1_Missense_Mutation_p.K170N|NDST3_uc003ibw.2_Missense_Mutation_p.K170N	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	170	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						CTAGTGAGAAGAGTGTACAGA	0.348													23	36					1.10923e-09	1.89767e-09	1	0	T	118975575	T	T	118975575	3	4	236	1	0	0	0	0	1	0	0	0	10311	933	33	2	512	2	NDST3	4	118975575	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	408	118975575	72178701	140	42778											
HSPA4L	22824	broad.mit.edu	37	chr4	128726265	128726265	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attagtagtatagaaattgtAggaggagcaacacgaattcc	16	10	10	5	1	0	1	0	0	0	1	1	4	1	3	1	2	2	4	1	2	8	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:128726265A>T	uc003ifm.2	+	9	1276	c.1023A>T	c.(1021-1023)GTA>GTT	p.V341V	HSPA4L_uc010iny.1_Silent_p.V300V|HSPA4L_uc011cgr.1_Silent_p.V308V	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	341					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TAGAAATTGTAGGAGGAGCAA	0.328													20	15					0	0	0	0	T	128726265	T	T	128726265	2	4	236	1	0	0	0	0	0	0	0	1	7452	407	15	5		5	HSPA4L	4	128726265	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	9750690	128726265	62428011	141	42779											
RNF150	57484	broad.mit.edu	37	chr4	141847144	141847144	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgcttaccgggatccctaggGctttaagaatgttcatcttg	8	14	10	9	1	2	1	1	0	1	1	3	2	3	2	2	2	2	3	2	2	4	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:141847144G>T	uc003iio.1	-	5	1628	c.974C>A	c.(973-975)GCC>GAC	p.A325D	RNF150_uc010iok.1_Missense_Mutation_p.A283D|RNF150_uc003iip.1_Missense_Mutation_p.A325D	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	325	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					GATCCCTAGGGCTTTAAGAAT	0.468													10	99					2.80697e-09	4.77721e-09	1	0	T	141847144	T	T	141847144	3	4	236	1	0	0	0	0	1	0	0	0	13516	1203	42	4	354	4	RNF150	4	141847144	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	13120879	141847144	49307132	142	42780											
DCLK2	166614	broad.mit.edu	37	chr4	151142904	151142904	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggaaaggtcattggtgatgGcaattttgcagtagtcaaag	12	12	13	4	0	2	1	2	1	0	0	2	2	2	2	0	4	1	3	0	4	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:151142904G>T	uc003ilm.3	+	7	1308	c.1208G>T	c.(1207-1209)GGC>GTC	p.G403V	DCLK2_uc003iln.3_Missense_Mutation_p.G402V|DCLK2_uc003ilo.3_Missense_Mutation_p.G420V|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	403	ATP (By similarity).|Protein kinase.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					ATTGGTGATGGCAATTTTGCA	0.338													7	29					0.000157383	0.00023777	1	0	T	151142904	T	T	151142904	3	4	236	1	0	0	0	0	1	0	0	0	4309	1203	42	4	1234	4	DCLK2	4	151142904	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	9295760	151142904	40011372	143	42781											
TMEM154	201799	broad.mit.edu	37	chr4	153565566	153565566	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaagcagcagggaaaacttaCactttcacgttttcacttcc	12	11	7	11	1	2	0	2	0	0	0	3	2	3	1	1	1	4	3	1	1	4	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:153565566C>T	uc003imw.1	-	4	498	c.392_splice	c.e4+1	p.V131_splice		NM_152680	NP_689893	Q6P9G4	TM154_HUMAN	transmembrane protein 154 precursor							integral to membrane					0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				GGAAAACTTACACTTTCACGT	0.413													9	23					0	0	0	0	T	153565566	T	T	153565566	5	4	236	1	0	0	0	0	0	0	1	0	16137	492	17	4	174	4	TMEM154	4	153565566	Splice_Site	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2422662	153565566	37588710	144	42782											
DCHS2	54798	broad.mit.edu	37	chr4	155219268	155219268	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagttccattgggccccaaGtccaggtcatcagctctcac	9	9	8	15	0	3	0	3	0	1	0	6	0	5	0	4	2	1	2	4	2	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:155219268G>T	uc003inw.2	-	18	4833	c.4833C>A	c.(4831-4833)GAC>GAA	p.D1611E		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1611	Cadherin 14.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGGCCCCAAGTCCAGGTCAT	0.418													36	30					1.07637e-12	1.95377e-12	1	0	T	155219268	T	T	155219268	3	4	236	1	0	0	0	0	1	0	0	0	4305	1020	36	4	3949	4	DCHS2	4	155219268	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1653702	155219268	35935008	145	42783											
DCHS2	54798	broad.mit.edu	37	chr4	155226261	155226261	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcccttacctcgaagggtgaAgacttcttgaatttctctgt	8	15	8	10	1	2	3	0	2	2	1	5	4	3	3	2	1	1	0	2	1	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:155226261A>G	uc003inw.2	-	16	4018	c.4018T>C	c.(4018-4020)TTC>CTC	p.F1340L		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1340	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CGAAGGGTGAAGACTTCTTGA	0.323													18	18					0	0	0	0	G	155226261	G	G	155226261	3	3	236	1	0	0	0	0	1	0	0	0	4305	72	3	5	4772	5	DCHS2	4	155226261	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	6993	155226261	35928015	146	42784											
CLCN3	1182	broad.mit.edu	37	chr4	170608837	170608837	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaaaagaaagaatcagcatGggaaatgacaaaaagtttgt	21	7	9	4	0	1	3	1	1	0	2	1	4	1	4	0	1	1	2	0	1	7	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:170608837G>T	uc003isi.2	+	4	856	c.347G>T	c.(346-348)TGG>TTG	p.W116L	CLCN3_uc003ish.2_Missense_Mutation_p.W116L|CLCN3_uc011cjz.1_Missense_Mutation_p.W99L|CLCN3_uc011cka.1_Missense_Mutation_p.W116L|CLCN3_uc003isj.1_Missense_Mutation_p.W89L	NM_001829	NP_001820	P51790	CLCN3_HUMAN	chloride channel 3 isoform b	116	Cytoplasmic (By similarity).				endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(2)|ovary(1)	3		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		GAATCAGCATGGGAAATGACA	0.343													12	9					0.000308642	0.000461319	1	0	T	170608837	T	T	170608837	3	4	236	1	0	0	0	0	1	0	0	0	3479	1357	47	4	357	4	CLCN3	4	170608837	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	15382576	170608837	20545439	147	42785											
GALNTL6	442117	broad.mit.edu	37	chr4	173873273	173873273	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtacaggcatctctccaCgggggacatctctgcccaga	9	7	12	13	1	2	1	0	0	2	1	5	3	3	3	2	4	2	2	2	4	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:173873273C>G	uc003isv.2	+	10	1971	c.1235C>G	c.(1234-1236)ACG>AGG	p.T412R		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	412	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						CATCTCTCCACGGGGGACATC	0.557													14	65					0	0	0	0	G	173873273	G	G	173873273	3	3	236	1	0	0	0	0	1	0	0	0	6260	536	19	3	1269	3	GALNTL6	4	173873273	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3264436	173873273	17281003	148	42786											
VEGFC	7424	broad.mit.edu	37	chr4	177605117	177605117	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttccaatatgaagggacaCaacgacacacttcttcacta	14	11	5	11	1	2	1	1	1	1	0	3	3	3	2	1	1	1	0	1	1	5	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:177605117C>G	uc003ius.1	-	7	1653	c.1223G>C	c.(1222-1224)TGT>TCT	p.C408S		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	408					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		TGAAGGGACACAACGACACAC	0.418													43	38					0	0	0	0	G	177605117	G	G	177605117	3	3	236	1	0	0	0	0	1	0	0	0	17220	478	17	4	43	4	VEGFC	4	177605117	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3731844	177605117	13549159	149	42787											
VEGFC	7424	broad.mit.edu	37	chr4	177649124	177649124	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccactcattatcaataccTgtcaagtcatagggaaatca	14	11	5	11	0	5	0	5	0	0	0	6	1	6	1	2	1	1	0	2	1	6	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:177649124T>A	uc003ius.1	-	3	792	c.362_splice	c.e3-1	p.S121_splice		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C						angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		TATCAATACCTGTCAAGTCAT	0.413													18	45					0	0	0	0	A	177649124	A	A	177649124	5	1	236	1	0	0	0	0	0	0	1	0	17220	1594	55	5	922	5	VEGFC	4	177649124	Splice_Site	SNP	T	TCGA-CV-7245-01A-11D-2012-08	44007	177649124	13505152	150	42788											
ZFP42	132625	broad.mit.edu	37	chr4	188924027	188924027	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctgggtggaagagccccCagtggggctaagcccaggca	8	4	17	12	0	0	1	0	0	0	1	0	2	0	2	4	6	2	2	4	6	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr4:188924027C>A	uc003izg.1	+	3	311	c.66C>A	c.(64-66)CCC>CCA	p.P22P	ZFP42_uc003izh.1_Silent_p.P22P|ZFP42_uc003izi.1_Silent_p.P22P	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	22					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GAAGAGCCCCCAGTGGGGCTA	0.552													16	88					3.52763e-06	5.56935e-06	1	0	A	188924027	A	A	188924027	2	1	236	1	0	0	0	0	0	0	0	1	17717	581	21	4		4	ZFP42	4	188924027	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	11274903	188924027	2230249	151	42789											
SLC6A18	348932	broad.mit.edu	37	chr5	1244767	1244767	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaccgggaggcggcccagccCctactggcggctgacctgga	6	4	16	15	3	0	1	0	1	0	0	0	4	0	3	5	6	2	1	5	6	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:1244767C>A	uc003jby.1	+	11	1664	c.1541C>A	c.(1540-1542)CCC>CAC	p.P514H		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	514	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CGGCCCAGCCCCTACTGGCGG	0.602													17	127					7.07596e-05	0.00010773	1	0	A	1244767	A	A	1244767	3	1	236	1	0	0	0	0	1	0	0	0	14745	623	22	4	1583	4	SLC6A18	5	1244767	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08		1244767	179670493	152	42790											
C5orf38	153571	broad.mit.edu	37	chr5	2752749	2752749	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttcagatttgtgttgtcaAaacactggggggatgattgt	9	15	12	5	0	2	2	2	1	0	1	2	3	2	3	0	3	1	1	0	3	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:2752749A>T	uc003jdc.2	+	2	331	c.214A>T	c.(214-216)AAA>TAA	p.K72*	C5orf38_uc011cmg.1_Nonsense_Mutation_p.K72*|C5orf38_uc011cmh.1_Intron|C5orf38_uc011cmi.1_Intron|C5orf38_uc011cmj.1_Intron	NM_178569	NP_848664	Q86SI9	CEI_HUMAN	hypothetical protein LOC153571 precursor	72						extracellular region					0				GBM - Glioblastoma multiforme(108;0.205)		TGTGTTGTCAAAACACTGGGG	0.507													42	169					0	0	0	0	T	2752749	T	T	2752749	4	4	236	1	0	0	0	0	0	1	0	0	2306	15	1	5	220	5	C5orf38	5	2752749	Nonsense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	1507982	2752749	178162511	153	42791											
CTNND2	1501	broad.mit.edu	37	chr5	11159792	11159793	+	Missense_Mutation	DNP	CG	TT	TT																															cctgagtgggggataatcacCgcgttggtcagtactgctag																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:11159792_11159793CG>TT	uc003jfa.1	-	12	2199_2200	c.2054_2055CG>AA	c.(2053-2055)GCG>GAA	p.A685E	CTNND2_uc010itt.2_Missense_Mutation_p.A594E|CTNND2_uc011cmy.1_Missense_Mutation_p.A348E|CTNND2_uc011cmz.1_Missense_Mutation_p.A252E|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.A252E	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	685	ARM 5.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding	p.A685V(1)		large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GGATAATCACCGCGTTGGTCAG	0.52													21	169					0	0	0	0	TT	11159793	TT	TT	11159792	3	4	236	1	0	0	0	0	1	0	0	0	4037	639	23	1	1666	1	CTNND2	5	11159792	Missense_Mutation	DNP	CG	TCGA-CV-7245-01A-11D-2012-08	8407043	11159792	169755468	154	42792											
CTNND2	1501	broad.mit.edu	37	chr5	11236908	11236908	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatctgaatcacttccggCagttccgggtctctccatcc	8	11	7	15	2	3	1	1	1	2	0	8	1	7	1	4	2	1	2	4	2	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:11236908C>A	uc003jfa.1	-	10	1801	c.1656G>T	c.(1654-1656)CTG>CTT	p.L552L	CTNND2_uc010itt.2_Silent_p.L461L|CTNND2_uc011cmy.1_Silent_p.L215L|CTNND2_uc011cmz.1_Silent_p.L119L|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.L119L	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	552	ARM 2.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TCACTTCCGGCAGTTCCGGGT	0.473													42	123					2.66277e-13	4.86029e-13	1	0	A	11236908	A	A	11236908	2	1	236	1	0	0	0	0	0	0	0	1	4037	697	25	4		4	CTNND2	5	11236908	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	77116	11236908	169678352	155	42793											
DNAH5	1767	broad.mit.edu	37	chr5	13807803	13807803	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctttaattattactgttttgGctgttccttgttcaccaatt	7	21	5	8	0	1	0	1	0	0	0	2	0	2	0	2	1	1	4	2	1	4	10			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:13807803G>T	uc003jfd.2	-	47	7826	c.7784C>A	c.(7783-7785)GCC>GAC	p.A2595D		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2595	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TACTGTTTTGGCTGTTCCTTG	0.289									Kartagener_syndrome				7	18					5.18039e-06	8.13943e-06	1	0	T	13807803	T	T	13807803	3	4	236	1	0	0	0	0	1	0	0	0	4626	1203	42	4	6222	4	DNAH5	5	13807803	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2570895	13807803	167107457	156	42794											
DNAH5	1767	broad.mit.edu	37	chr5	13839501	13839501	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttattacaagcctgtcagtgCagcctaaaaattcattctgg	12	13	7	9	0	3	0	2	0	1	0	3	0	3	0	2	1	4	1	2	1	6	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:13839501C>A	uc003jfd.2	-	35	5888	c.5846G>T	c.(5845-5847)TGC>TTC	p.C1949F		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1949	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCTGTCAGTGCAGCCTAAAAA	0.423									Kartagener_syndrome				27	140					7.26314e-15	1.36636e-14	1	0	A	13839501	A	A	13839501	3	1	236	1	0	0	0	0	1	0	0	0	4626	710	25	4	8208	4	DNAH5	5	13839501	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	31698	13839501	167075759	157	42795											
FBXL7	23194	broad.mit.edu	37	chr5	15937116	15937116	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcttcaacctcaagcggCtcagcctcaagtcctgcgag	9	8	9	15	2	4	0	4	0	0	0	5	1	5	0	3	1	5	2	3	1	3	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:15937116C>A	uc003jfn.1	+	4	1778	c.1297C>A	c.(1297-1299)CTC>ATC	p.L433I		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	433	LRR 10.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CCTCAAGCGGCTCAGCCTCAA	0.587													5	81					3.59834e-05	5.52984e-05	1	0	A	15937116	A	A	15937116	3	1	236	1	0	0	0	0	1	0	0	0	5756	797	28	4	1311	4	FBXL7	5	15937116	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2097615	15937116	164978144	158	42796											
PRDM9	56979	broad.mit.edu	37	chr5	23522987	23522987	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcagccaacaatggatactCctggctggtaagaagagcct	12	7	12	10	0	0	2	0	0	0	2	1	3	1	3	3	4	4	3	3	4	5	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:23522987C>A	uc003jgo.2	+	8	1057	c.875C>A	c.(874-876)TCC>TAC	p.S292Y		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	292	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AATGGATACTCCTGGCTGGTA	0.502										HNSCC(3;0.000094)			17	141					0.000132079	0.000200157	1	0	A	23522987	A	A	23522987	3	1	236	1	0	0	0	0	1	0	0	0	12525	855	30	2	901	2	PRDM9	5	23522987	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	7585871	23522987	157392273	159	42797											
ADAMTS12	81792	broad.mit.edu	37	chr5	33684161	33684161	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggagatgttaacactgtCtaaacagtaaacagaagaca	17	8	9	7	0	1	3	0	0	1	3	1	4	1	3	0	1	3	2	0	1	6	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:33684161C>A	uc003jia.1	-	4	798	c.635_splice	c.e4-1	p.D212_splice	ADAMTS12_uc010iuq.1_Splice_Site_p.D212_splice	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TTAACACTGTCTAAACAGTAA	0.413										HNSCC(64;0.19)			7	37					2.74318e-10	4.76779e-10	1	0	A	33684161	A	A	33684161	5	1	236	1	0	0	0	0	0	0	1	0	257	927	32	2	4234	2	ADAMTS12	5	33684161	Splice_Site	SNP	C	TCGA-CV-7245-01A-11D-2012-08	10161174	33684161	147231099	160	42798											
SPEF2	79925	broad.mit.edu	37	chr5	35641597	35641597	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacttaaccttctgggtgtgCagtttgatcagaatgtggcc	8	13	11	9	0	2	2	1	1	1	1	2	2	2	2	2	2	2	2	2	2	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:35641597C>T	uc003jjo.2	+	3	337	c.226C>T	c.(226-228)CAG>TAG	p.Q76*	SPEF2_uc003jjn.1_Nonsense_Mutation_p.Q76*|SPEF2_uc003jjq.3_Nonsense_Mutation_p.Q76*	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	76	CH.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCTGGGTGTGCAGTTTGATCA	0.388													10	94					0	0	0	0	T	35641597	T	T	35641597	4	4	236	1	0	0	0	0	0	1	0	0	15101	711	25	4	236	4	SPEF2	5	35641597	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1957436	35641597	145273663	161	42799											
RANBP3L	202151	broad.mit.edu	37	chr5	36253851	36253851	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcatttgggcccagagtttGctgttgaggatcagccttag	7	14	12	8	0	2	2	2	1	0	1	2	3	2	3	2	2	2	3	2	2	1	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:36253851G>T	uc003jkh.2	-	12	1558	c.1065C>A	c.(1063-1065)AGC>AGA	p.S355R	RANBP3L_uc011cow.1_Missense_Mutation_p.S380R	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	355	RanBD1.				intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CCCAGAGTTTGCTGTTGAGGA	0.388													14	120					8.60227e-14	1.58488e-13	1	0	T	36253851	T	T	36253851	3	4	236	1	0	0	0	0	1	0	0	0	13095	1310	46	4	344	4	RANBP3L	5	36253851	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	612254	36253851	144661409	162	42800											
NUP155	9631	broad.mit.edu	37	chr5	37331833	37331833	+	Frame_Shift_Del	DEL	A	-	-																															tctcttctccatctcctcccAcattactcacaagtagatgc																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:37331833delA	uc003jku.1	-	14	1701	c.1583delT	c.(1582-1584)GTGfs	p.V528fs	NUP155_uc003jkt.1_Frame_Shift_Del_p.V469fs|NUP155_uc010iuz.1_Frame_Shift_Del_p.V528fs	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	528					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATCTCCTCCCACATTACTCAC	0.328													---	---	---								-	37331833	-	-	37331833	7	5	236	1	0	1	0	1	0	0	0	0	10810	159	6	0	2680	0	NUP155	5	37331833	Frame_Shift_Del	DEL	A	TCGA-CV-7245-01A-11D-2012-08	1077982	37331833	143583427	163	42801											
MRPS30	10884	broad.mit.edu	37	chr5	44809461	44809461	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcccgagcccgaacccgaaCctgaacctgcgctggacctc	9	4	10	18	4	0	1	0	1	0	0	1	5	0	2	6	1	6	1	6	1	3	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:44809461C>T	uc003joh.2	+	1	435	c.397C>T	c.(397-399)CCT>TCT	p.P133S	MRPS30_uc003joi.1_5'Flank	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	133					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					cgaacccgaacctgaaccTGC	0.572													4	24					0	0	0	0	T	44809461	T	T	44809461	3	4	236	1	0	0	0	0	1	0	0	0	9893	507	18	4	399	4	MRPS30	5	44809461	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	7477628	44809461	136105799	164	42802											
MRPS30	10884	broad.mit.edu	37	chr5	44815101	44815101	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttttcctttttctgctacCagctaaatactttggcactg	8	17	5	11	0	1	0	0	0	1	0	2	0	2	0	2	1	4	3	2	1	4	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:44815101C>T	uc003joh.2	+	5	1155	c.1117C>T	c.(1117-1119)CAG>TAG	p.Q373*		NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	373					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					TTTCTGCTACCAGCTAAATAC	0.388													27	153					0	0	0	0	T	44815101	T	T	44815101	4	4	236	1	0	0	0	0	0	1	0	0	9893	595	21	4	1135	4	MRPS30	5	44815101	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5640	44815101	136100159	165	42803											
MAP3K1	4214	broad.mit.edu	37	chr5	56168720	56168720	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcagcaaaccgtacagcAgcagcctttggctggatcac	12	6	10	13	1	1	0	1	0	0	0	1	1	1	1	2	2	7	6	2	2	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:56168720A>T	uc003jqw.3	+	9	2075	c.1574A>T	c.(1573-1575)CAG>CTG	p.Q525L		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	525					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		ACCGTACAGCAGCAGCCTTTG	0.433													20	17					0	0	0	0	T	56168720	T	T	56168720	3	4	236	1	0	0	0	0	1	0	0	0	9296	188	7	5	1608	5	MAP3K1	5	56168720	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	11353619	56168720	124746540	166	42804											
ERBB2IP	55914	broad.mit.edu	37	chr5	65349325	65349325	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaagctcatgataaaaaaGattttaacttacctgaatat	18	13	4	6	0	2	3	2	2	0	1	2	3	2	3	1	0	3	1	1	0	8	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:65349325G>C	uc003juk.1	+	21	2487	c.2179G>C	c.(2179-2181)GAT>CAT	p.D727H	ERBB2IP_uc003jui.1_Missense_Mutation_p.D727H|ERBB2IP_uc003juj.1_Missense_Mutation_p.D727H|ERBB2IP_uc011cqx.1_Missense_Mutation_p.D727H|ERBB2IP_uc011cqy.1_Missense_Mutation_p.D727H|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.D723H|ERBB2IP_uc003jul.1_Missense_Mutation_p.D723H	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	727					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TGATAAAAAAGATTTTAACTT	0.308													22	67					0	0	0	0	C	65349325	C	C	65349325	3	2	236	1	0	0	0	0	1	0	0	0	5231	942	33	2	2253	2	ERBB2IP	5	65349325	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	9180605	65349325	115565935	167	42805											
BDP1	55814	broad.mit.edu	37	chr5	70835391	70835391	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttcctcacaaggtaccaaTgatggaagcaccgaagctgc	13	8	9	11	1	1	1	1	1	0	0	2	3	2	2	3	2	4	3	3	2	5	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:70835391T>C	uc003kbp.1	+	28	6200	c.5937T>C	c.(5935-5937)AAT>AAC	p.N1979N	BDP1_uc003kbo.2_Silent_p.N1979N|BDP1_uc003kbq.1_RNA|BDP1_uc003kbr.1_Intron	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1979					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AAGGTACCAATGATGGAAGCA	0.348													10	23					0	0	0	0	C	70835391	C	C	70835391	2	2	236	1	0	0	0	0	0	0	0	1	1397	1461	51	5		5	BDP1	5	70835391	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	5486066	70835391	110079869	168	42806											
GPR98	84059	broad.mit.edu	37	chr5	90015959	90015959	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aactggaggtgctagactagGggtgcatgttcaaaccctga	11	9	13	8	0	1	2	1	1	0	1	1	3	1	3	1	4	4	3	1	4	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:90015959G>C	uc003kju.2	+	44	9638	c.9542G>C	c.(9541-9543)GGG>GCG	p.G3181A	GPR98_uc003kjt.2_Missense_Mutation_p.G887A|GPR98_uc003kjv.2_Missense_Mutation_p.G781A	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3181	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCTAGACTAGGGGTGCATGTT	0.413													19	51					0	0	0	0	C	90015959	C	C	90015959	3	2	236	1	0	0	0	0	1	0	0	0	6760	1232	43	4	9716	4	GPR98	5	90015959	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	19180568	90015959	90899301	169	42807											
SLCO6A1	133482	broad.mit.edu	37	chr5	101709176	101709176	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcaatagtagtgaagatgatAgtgcatagtttgcaaagaaa	17	10	11	3	0	0	4	0	2	0	2	0	4	0	4	0	0	2	5	0	0	8	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:101709176A>T	uc003knn.2	-	13	2212	c.2040T>A	c.(2038-2040)ACT>ACA	p.T680T	SLCO6A1_uc003kno.2_Silent_p.T427T|SLCO6A1_uc003knp.2_Silent_p.T680T|SLCO6A1_uc003knq.2_Silent_p.T618T	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	680	Helical; Name=12; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TGAAGATGATAGTGCATAGTT	0.303													10	42					0	0	0	0	T	101709176	T	T	101709176	2	4	236	1	0	0	0	0	0	0	0	1	14796	407	15	5		5	SLCO6A1	5	101709176	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	11693217	101709176	79206084	170	42808											
PPIP5K2	23262	broad.mit.edu	37	chr5	102493935	102493935	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttacttttggttctaaaatgGggaggtgaattaactcctgc	10	15	10	6	0	1	1	0	1	1	0	2	2	2	2	1	4	3	1	1	4	5	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:102493935G>T	uc003kod.3	+	15	2052	c.1533G>T	c.(1531-1533)TGG>TGT	p.W511C	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.W511C	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	511					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						TTCTAAAATGGGGAGGTGAAT	0.388													8	11					5.18039e-06	8.13943e-06	1	0	T	102493935	T	T	102493935	3	4	236	1	0	0	0	0	1	0	0	0	12393	1241	43	4	1587	4	PPIP5K2	5	102493935	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	784759	102493935	78421325	171	42809											
MEGF10	84466	broad.mit.edu	37	chr5	126738373	126738373	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtccaggatacacaggggaaCggtaagggatgcccttgtat	11	8	14	8	1	0	0	0	0	0	0	1	3	1	3	2	5	3	2	2	5	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:126738373C>T	uc003kuh.3	+	9	1278	c.916C>T	c.(916-918)CGG>TGG	p.R306W	MEGF10_uc010jdc.1_Missense_Mutation_p.R306W|MEGF10_uc010jdd.1_Missense_Mutation_p.R306W|MEGF10_uc003kui.3_Missense_Mutation_p.R306W	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	306	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EGF-like 5.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CACAGGGGAACGGTAAGGGAT	0.478													33	26					0	0	0	0	T	126738373	T	T	126738373	3	4	236	1	0	0	0	0	1	0	0	0	9513	550	19	1	942	1	MEGF10	5	126738373	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	24244438	126738373	54176887	172	42810											
SEC24A	10802	broad.mit.edu	37	chr5	134029560	134029560	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctgtctttcaaacacaactCccaactcttggagtgggagc	10	11	8	12	0	4	0	1	0	3	0	5	2	5	2	1	2	4	0	1	2	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:134029560C>A	uc003kzs.2	+	13	2211	c.1923C>A	c.(1921-1923)CTC>CTA	p.L641L	SEC24A_uc011cxu.1_Silent_p.L405L	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	641					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAACACAACTCCCAACTCTTG	0.498													15	37					1.67942e-08	2.79998e-08	1	0	A	134029560	A	A	134029560	2	1	236	1	0	0	0	0	0	0	0	1	14059	842	30	2		2	SEC24A	5	134029560	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	7291187	134029560	46885700	173	42811											
IK	3550	broad.mit.edu	37	chr5	140033549	140033549	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcagctgcagagaagagaaGacagttgatccaggagtcca	15	6	12	8	0	1	4	1	1	0	3	3	7	3	5	2	1	2	3	2	1	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:140033549G>A	uc003lgq.2	+	6	541	c.431G>A	c.(430-432)AGA>AAA	p.R144K	IK_uc011czk.1_Missense_Mutation_p.R144K	NM_006083	NP_006074	Q13123	RED_HUMAN	RED protein	144					cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAAGAGAAGACAGTTGATC	0.368													14	9					0	0	0	0	A	140033549	A	A	140033549	3	1	236	1	0	0	0	0	1	0	0	0	7647	942	33	2	453	2	IK	5	140033549	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	6003989	140033549	40881711	174	42812											
PCDHA3	56145	broad.mit.edu	37	chr5	140180929	140180929	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accttcgtgggccgcatcgcGcaggacctggggctggagct	5	7	16	13	4	0	0	0	0	0	0	2	2	0	2	3	5	1	4	3	5	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:140180929G>T	uc003lhf.2	+	1	147	c.147G>T	c.(145-147)GCG>GCT	p.A49A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.A49A	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	49	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGCATCGCGCAGGACCTGG	0.647													35	86					2.42023e-17	4.66013e-17	1	0	T	140180929	T	T	140180929	2	4	236	1	0	0	0	0	0	0	0	1	11579	1074	38	3		3	PCDHA3	5	140180929	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	147380	140180929	40734331	175	42813											
PCDHB2	56133	broad.mit.edu	37	chr5	140475671	140475671	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgacttcgggacacccaggCtgaaaaccgagcacaacata	14	4	9	14	3	0	1	0	1	0	0	1	4	0	2	3	2	3	2	3	2	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:140475671C>A	uc003lil.2	+	1	1435	c.1297C>A	c.(1297-1299)CTG>ATG	p.L433M	PCDHB2_uc003lim.1_Missense_Mutation_p.L94M	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	433	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACACCCAGGCTGAAAACCGA	0.557													79	51					3.00167e-28	6.17954e-28	1	0	A	140475671	A	A	140475671	3	1	236	1	0	0	0	0	1	0	0	0	11596	796	28	4	1299	4	PCDHB2	5	140475671	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	294742	140475671	40439589	176	42814											
PCDHB8	56128	broad.mit.edu	37	chr5	140558615	140558615	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcttttctggaaaatgcaccGttctgattcaagtgatagat	11	14	9	7	1	3	3	1	2	2	1	3	4	3	4	1	1	1	3	1	1	4	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:140558615G>A	uc011dai.1	+	1	1186	c.1000G>A	c.(1000-1002)GTT>ATT	p.V334I	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	334	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAATGCACCGTTCTGATTCA	0.433													38	352					0	0	0	0	A	140558615	A	A	140558615	3	1	236	1	0	0	0	0	1	0	0	0	11602	1145	40	1	1002	1	PCDHB8	5	140558615	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	82944	140558615	40356645	177	42815											
PCDHB12	56124	broad.mit.edu	37	chr5	140589218	140589218	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgagtttgagcaggcttttTatgaggtgaagattctggag	9	14	14	4	0	1	5	0	4	1	1	1	6	1	6	0	3	1	3	0	3	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:140589218T>G	uc003liz.2	+	1	928	c.739T>G	c.(739-741)TAT>GAT	p.Y247D	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	247	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGGCTTTTTATGAGGTGAA	0.502													97	56					0	0	0	0	G	140589218	G	G	140589218	3	3	236	1	0	0	0	0	1	0	0	0	11591	1754	61	5	741	5	PCDHB12	5	140589218	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	30603	140589218	40326042	178	42816											
PCDHB12	56124	broad.mit.edu	37	chr5	140590088	140590088	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgggcgccacagaccacGgctccccggctttgagcagc	6	5	14	16	4	0	2	0	1	0	1	1	2	1	2	4	3	2	3	4	3	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:140590088G>T	uc003liz.2	+	1	1798	c.1609G>T	c.(1609-1611)GGC>TGC	p.G537C	PCDHB12_uc011dak.1_Missense_Mutation_p.G200C	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	537	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACAGACCACGGCTCCCCGGC	0.677													49	29					5.34276e-22	1.06422e-21	1	0	T	140590088	T	T	140590088	3	4	236	1	0	0	0	0	1	0	0	0	11591	1116	39	3	1611	3	PCDHB12	5	140590088	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	870	140590088	40325172	179	42817											
HMHB1	57824	broad.mit.edu	37	chr5	143200051	143200051	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcttttctataggttctcTgcatgtttggaagtcggaat	8	18	9	6	1	3	0	0	0	3	0	5	2	3	2	0	3	1	3	0	3	4	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:143200051T>C	uc003lnj.2	+	2	151	c.44T>C	c.(43-45)CTG>CCG	p.L15P		NM_021182	NP_067005	O97980	HMHB1_HUMAN	minor histocompatibility antigen HB-1	15	Loss of recognition by cytotoxic T lymphocyte (CTL).			L->A: Complete loss of CTL recognition.							0		Acute lymphoblastic leukemia(2;0.0236)|all_hematologic(2;0.041)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			ATAGGTTCTCTGCATGTTTGG	0.393													34	73					0	0	0	0	C	143200051	C	C	143200051	3	2	236	1	0	0	0	0	1	0	0	0	7280	1580	55	5	50	5	HMHB1	5	143200051	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2609963	143200051	37715209	180	42818											
PLAC8L1	153770	broad.mit.edu	37	chr5	145477757	145477757	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agacactgaagagaccggtgCtccagcccccgccagtctgg	9	5	12	15	2	1	3	0	1	1	2	2	4	2	3	5	2	2	1	5	2	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:145477757C>A	uc003lnv.2	-	2	290	c.218G>T	c.(217-219)AGC>ATC	p.S73I	PLAC8L1_uc011dbp.1_RNA	NM_001029869	NP_001025040	A1L4L8	PL8L1_HUMAN	PLAC8-like 1	73											0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGACCGGTGCTCCAGCCCCC	0.512													26	13					2.79863e-10	4.84701e-10	1	0	A	145477757	A	A	145477757	3	1	236	1	0	0	0	0	1	0	0	0	12071	797	28	4	327	4	PLAC8L1	5	145477757	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2277706	145477757	35437503	181	42819											
SLC36A2	153201	broad.mit.edu	37	chr5	150722462	150722462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggttaccttccccagtgagCgtgattctggagccaggcgt	7	10	13	11	2	1	2	0	2	1	0	2	3	2	3	4	3	3	1	4	3	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:150722462C>T	uc003lty.2	-	4	557	c.427G>A	c.(427-429)GCT>ACT	p.A143T	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_5'UTR|SLC36A2_uc010jhv.2_Missense_Mutation_p.A143T|SLC36A2_uc011dct.1_Missense_Mutation_p.A143T	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	143	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCCAGTGAGCGTGATTCTGG	0.537													23	26					0	0	0	0	T	150722462	T	T	150722462	3	4	236	1	0	0	0	0	1	0	0	0	14658	768	27	1	1052	1	SLC36A2	5	150722462	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5244705	150722462	30192798	182	42820											
ITK	3702	broad.mit.edu	37	chr5	156671418	156671418	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgctgcagagaccctgcTgggcatgtgtctggatgtgt	5	14	14	8	0	1	1	0	0	1	1	1	3	1	2	1	2	3	4	1	2	0	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:156671418T>A	uc003lwo.1	+	13	1461	c.1379T>A	c.(1378-1380)CTG>CAG	p.L460Q		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	460	Protein kinase.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAGACCCTGCTGGGCATGTGT	0.572			T	SYK	peripheral T-cell lymphoma								17	25					0	0	0	0	A	156671418	A	A	156671418	3	1	236	1	0	0	0	0	1	0	0	0	7948	1580	55	5	1429	5	ITK	5	156671418	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	5948956	156671418	24243842	183	42821											
FABP6	2172	broad.mit.edu	37	chr5	159659189	159659189	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgggcaggacttcacttggtCccagcactactccgggggcc	6	8	13	14	1	1	0	1	0	0	0	3	1	3	1	3	5	2	2	3	5	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:159659189C>A	uc003lya.1	+	2	280	c.152C>A	c.(151-153)TCC>TAC	p.S51Y	FABP6_uc003lxx.1_Missense_Mutation_p.S100Y|FABP6_uc003lxz.1_Missense_Mutation_p.S100Y	NM_001445	NP_001436	P51161	FABP6_HUMAN	gastrotropin isoform 2	51					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCACTTGGTCCCAGCACTAC	0.562													9	8					0.000442599	0.000660536	1	0	A	159659189	A	A	159659189	3	1	236	1	0	0	0	0	1	0	0	0	5389	855	30	2	313	2	FABP6	5	159659189	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2987771	159659189	21256071	184	42822											
GABRA6	2559	broad.mit.edu	37	chr5	161115970	161115971	+	Frame_Shift_Ins	INS	-	T	T																															ttaggagtatacgatggatgINStttttttccgccagacctgg																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:161115970_161115971insT	uc003lyu.2	+	4	579_580	c.241_242insT	c.(241-243)GTTfs	p.V81fs	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	81	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TACGATGGATGTTTTTTTCCGC	0.401										TCGA Ovarian(5;0.080)			---	---	---								T	161115971	T	T	161115970	7	5	236	1	0	1	1	0	0	0	0	0	6199	1377	48	0	255	0	GABRA6	5	161115970	Frame_Shift_Ins	INS	-	TCGA-CV-7245-01A-11D-2012-08	1456781	161115970	19799290	185	42823											
GABRA1	2554	broad.mit.edu	37	chr5	161302615	161302615	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atttggaggacttccctatgGatgcccatgcttgcccacta	8	12	9	12	0	0	0	0	0	0	0	1	3	1	3	3	3	3	1	3	3	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:161302615G>T	uc010jiw.2	+	7	994	c.526G>T	c.(526-528)GAT>TAT	p.D176Y	GABRA1_uc010jix.2_Missense_Mutation_p.D176Y|GABRA1_uc010jiy.2_Missense_Mutation_p.D176Y|GABRA1_uc003lyx.3_Missense_Mutation_p.D176Y|GABRA1_uc010jiz.2_Missense_Mutation_p.D176Y|GABRA1_uc010jja.2_Missense_Mutation_p.D176Y|GABRA1_uc010jjb.2_Missense_Mutation_p.D176Y	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	176	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CTTCCCTATGGATGCCCATGC	0.383													17	52					2.35188e-11	4.13897e-11	1	0	T	161302615	T	T	161302615	3	4	236	1	0	0	0	0	1	0	0	0	6194	1174	41	2	544	2	GABRA1	5	161302615	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	186645	161302615	19612645	186	42824											
GABRP	2568	broad.mit.edu	37	chr5	170239158	170239158	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggattgttgattatttcAcaattcaaaaccccagtaat	14	13	6	8	0	2	1	2	1	0	0	2	2	2	2	2	1	1	3	2	1	5	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:170239158A>G	uc003mau.2	+	10	1417	c.1219A>G	c.(1219-1221)ACA>GCA	p.T407A	GABRP_uc011dev.1_3'UTR	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	407	Cytoplasmic (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGATTATTTCACAATTCAAAA	0.373													13	33					0	0	0	0	G	170239158	G	G	170239158	3	3	236	1	0	0	0	0	1	0	0	0	6208	159	6	5	1253	5	GABRP	5	170239158	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	8936543	170239158	10676102	187	42825											
NSD1	64324	broad.mit.edu	37	chr5	176675284	176675284	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctaaaaaaatgcagggtGaacgcggtggaggagctgca	13	6	14	8	2	1	1	0	1	1	0	1	3	1	3	1	4	4	3	1	4	5	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:176675284G>T	uc003mfr.3	+	11	4738	c.4600G>T	c.(4600-4602)GAA>TAA	p.E1534*	NSD1_uc003mft.3_Nonsense_Mutation_p.E1265*|NSD1_uc003mfs.1_Nonsense_Mutation_p.E1431*|NSD1_uc011dfx.1_Nonsense_Mutation_p.E1182*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1534					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AATGCAGGGTGAACGCGGTGG	0.498			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			15	5					3.27435e-08	5.44985e-08	1	0	T	176675284	T	T	176675284	4	4	236	1	0	0	0	0	0	1	0	0	10723	1291	45	2	4638	2	NSD1	5	176675284	Nonsense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	6436126	176675284	4239976	188	42826											
MAML1	9794	broad.mit.edu	37	chr5	179192840	179192840	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtttaatgaggacttcgagGagaagaaggacccagagtct	13	9	13	6	1	1	4	0	1	1	3	2	8	1	6	1	3	0	1	1	3	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr5:179192840G>T	uc003mkm.2	+	2	1092	c.829G>T	c.(829-831)GAG>TAG	p.E277*	MAML1_uc003mkn.1_Nonsense_Mutation_p.E277*	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	277					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGACTTCGAGGAGAAGAAGGA	0.512													26	69					7.68411e-24	1.55584e-23	1	0	T	179192840	T	T	179192840	4	4	236	1	0	0	0	0	0	1	0	0	9258	1175	41	2	835	2	MAML1	5	179192840	Nonsense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2517556	179192840	1722420	189	42827											
DSP	1832	broad.mit.edu	37	chr6	7583613	7583613	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggccaagagaaagaaattaAtcagcccagaatccacagtc	18	5	8	10	0	1	3	1	0	0	3	3	4	2	3	3	1	1	0	3	1	5	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:7583613A>G	uc003mxp.1	+	24	6397	c.6118A>G	c.(6118-6120)ATC>GTC	p.I2040V	DSP_uc003mxq.1_Missense_Mutation_p.I1441V	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2040	Plectin 1.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAAGAAATTAATCAGCCCAGA	0.488													40	41					0	0	0	0	G	7583613	G	G	7583613	3	3	236	1	0	0	0	0	1	0	0	0	4803	101	4	5	6212	5	DSP	6	7583613	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08		7583613	163531454	190	42828											
SCGN	10590	broad.mit.edu	37	chr6	25670229	25670229	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttctcttggcgccacagaaCttcctccgagacctctttct	6	13	6	16	2	3	2	0	0	3	2	6	3	5	2	4	1	1	0	4	1	1	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:25670229C>A	uc003nfb.2	+	6	599	c.396C>A	c.(394-396)AAC>AAA	p.N132K	SCGN_uc010jpz.2_Missense_Mutation_p.T42N	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	132	EF-hand 3.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						CGCCACAGAACTTCCTCCGAG	0.378													42	170					1.41504e-22	2.83007e-22	1	0	A	25670229	A	A	25670229	3	1	236	1	0	0	0	0	1	0	0	0	13968	564	20	4	418	4	SCGN	6	25670229	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	18086616	25670229	145444838	191	42829											
HIST1H2BI	8346	broad.mit.edu	37	chr6	26273408	26273408	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttatgaactccttcgtcaacGacattttcgagcgcattgca	10	13	7	11	4	1	1	1	1	0	0	4	3	2	1	1	0	4	2	1	0	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:26273408G>A	uc003nhk.2	+	1	205	c.205G>A	c.(205-207)GAC>AAC	p.D69N	HIST1H3G_uc003nhi.2_5'Flank	NM_003525	NP_003516	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	69					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CTTCGTCAACGACATTTTCGA	0.567													63	189					0	0	0	0	A	26273408	A	A	26273408	3	1	236	1	0	0	0	0	1	0	0	0	7187	1058	37	1	207	1	HIST1H2BI	6	26273408	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	603179	26273408	144841659	192	42830											
ABT1	29777	broad.mit.edu	37	chr6	26598238	26598238	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagggatgggtggagttccGtgacaagcgcatagccaagc	10	6	16	9	3	0	1	0	1	0	0	1	4	1	3	2	3	3	2	2	3	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:26598238G>A	uc003nii.2	+	2	369	c.338G>A	c.(337-339)CGT>CAT	p.R113H		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	113	RRM.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1						GTGGAGTTCCGTGACAAGCGC	0.597													11	44					0	0	0	0	A	26598238	A	A	26598238	3	1	236	1	0	0	0	0	1	0	0	0	101	1145	40	1	344	1	ABT1	6	26598238	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	324830	26598238	144516829	193	42831											
ZNF184	7738	broad.mit.edu	37	chr6	27419371	27419371	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgttgatgctgagttagaTgggagctctggctaaaggtc	8	13	14	6	1	1	3	0	2	1	1	3	4	1	4	0	3	2	5	0	3	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:27419371T>A	uc003njj.2	-	5	2778	c.1967A>T	c.(1966-1968)CAT>CTT	p.H656L	ZNF184_uc010jqv.2_Missense_Mutation_p.H656L|ZNF184_uc003nji.2_Missense_Mutation_p.H656L	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	656	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTGAGTTAGATGGGAGCTCTG	0.423													18	79					0	0	0	0	A	27419371	A	A	27419371	3	1	236	1	0	0	0	0	1	0	0	0	17818	1464	51	5	292	5	ZNF184	6	27419371	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	821133	27419371	143695696	194	42832											
UBD	10537	broad.mit.edu	37	chr6	29524075	29524075	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatttttttcacgctgtcaTatgggttggcatcaaaggtc	8	16	10	7	1	3	1	3	1	0	0	4	1	3	1	0	3	0	3	0	3	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:29524075T>C	uc003nmo.2	-	2	304	c.80A>G	c.(79-81)TAT>TGT	p.Y27C	GABBR1_uc003nmp.3_3'UTR	NM_006398	NP_006389	O15205	UBD_HUMAN	ubiquitin D	27	Ubiquitin 1.				aggresome assembly|myeloid dendritic cell differentiation|negative regulation of mitotic prometaphase|positive regulation of apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	aggresome|cytoplasm|nucleus	proteasome binding				0						CACGCTGTCATATGGGTTGGC	0.488													20	50					0	0	0	0	C	29524075	C	C	29524075	3	2	236	1	0	0	0	0	1	0	0	0	16911	1406	49	5	421	5	UBD	6	29524075	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2104704	29524075	141590992	195	42833											
MSH5	4439	broad.mit.edu	37	chr6	31726375	31726375	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcttcacagtcctccccaaCatagatcctgaaattgatga	12	10	6	13	1	1	4	1	3	0	1	4	4	4	4	4	0	1	1	4	0	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:31726375C>A	uc003nwv.1	+	14	1273	c.1194C>A	c.(1192-1194)AAC>AAA	p.N398K	MSH5_uc003nwt.1_Missense_Mutation_p.N415K|MSH5_uc003nwu.1_Missense_Mutation_p.N398K|MSH5_uc003nww.1_Missense_Mutation_p.N398K|MSH5_uc003nwx.1_Missense_Mutation_p.N415K|MSH5_uc011dof.1_Missense_Mutation_p.N97K|MSH5_uc003nwy.1_Missense_Mutation_p.N72K|MSH5_uc003nwz.3_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	398					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						TCCTCCCCAACATAGATCCTG	0.532								Direct_reversal_of_damage|MMR					19	39					8.34094e-07	1.33837e-06	1	0	A	31726375	A	A	31726375	3	1	236	1	0	0	0	0	1	0	0	0	9926	477	17	4	1295	4	MSH5	6	31726375	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2202300	31726375	139388692	196	42834											
EHMT2	10919	broad.mit.edu	37	chr6	31854582	31854582	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acacagccaccacgctgcacCatgtaacgggctacctccag	11	5	8	17	2	0	0	0	0	0	0	1	0	1	0	5	1	4	4	5	1	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:31854582C>T	uc003nxz.1	-	17	2221	c.2211G>A	c.(2209-2211)ATG>ATA	p.M737I	EHMT2_uc003nxv.1_5'Flank|EHMT2_uc003nxw.1_5'Flank|EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Missense_Mutation_p.M528I|EHMT2_uc011don.1_Missense_Mutation_p.M760I|EHMT2_uc003nya.1_Missense_Mutation_p.M703I	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	737	ANK 3.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CACGCTGCACCATGTAACGGG	0.622													35	158					0	0	0	0	T	31854582	T	T	31854582	3	4	236	1	0	0	0	0	1	0	0	0	5006	594	21	4	1469	4	EHMT2	6	31854582	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	128207	31854582	139260485	197	42835											
C4A	720	broad.mit.edu	37	chr6	31962428	31962428	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtctctgaaggtggtggctCgagggtccttcgaattccct	5	13	13	10	2	1	1	0	1	1	0	6	3	3	1	2	4	0	1	2	4	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:31962428C>T	uc011doy.1	+	21	2797	c.2746C>T	c.(2746-2748)CGA>TGA	p.R916*	C4A_uc011doz.1_Nonsense_Mutation_p.R916*	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	916					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						GGTGGTGGCTCGAGGGTCCTT	0.637													23	71					0	0	0	0	T	31962428	T	T	31962428	4	4	236	1	0	0	0	0	0	1	0	0	2257	876	31	1	2828	1	C4A	6	31962428	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	107846	31962428	139152639	198	42836											
FANCE	2178	broad.mit.edu	37	chr6	35425701	35425701	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgtctccccaggggttagaGggattggaggatgccccccc	6	9	14	12	0	1	1	0	0	1	1	2	4	1	4	5	5	1	1	5	5	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:35425701G>A	uc003oko.1	+	4	1094	c.909G>A	c.(907-909)GAG>GAA	p.E303E	FANCE_uc010jvw.1_Silent_p.E303E	NM_021922	NP_068741	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	303	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			ovary(1)|lung(1)|skin(1)	3						AGGGGTTAGAGGGATTGGAGG	0.562			N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				42	53					0	0	0	0	A	35425701	A	A	35425701	2	1	236	1	0	0	0	0	0	0	0	1	5698	991	35	4		4	FANCE	6	35425701	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3463273	35425701	135689366	199	42837											
KIF6	221458	broad.mit.edu	37	chr6	39507828	39507828	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccccaaaatgctgaagtcCtgggcctgtgagggagctga	9	9	13	10	0	0	3	0	3	0	0	2	4	2	4	4	2	2	2	4	2	3	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:39507828C>A	uc003oot.2	-	13	1691	c.1596G>T	c.(1594-1596)CAG>CAT	p.Q532H	KIF6_uc010jwz.1_Translation_Start_Site|KIF6_uc010jxa.1_Missense_Mutation_p.Q323H|KIF6_uc011dua.1_Missense_Mutation_p.Q532H|KIF6_uc010jxb.1_Intron	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	532					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TGCTGAAGTCCTGGGCCTGTG	0.458													103	114					3.01496e-42	6.36707e-42	1	0	A	39507828	A	A	39507828	3	1	236	1	0	0	0	0	1	0	0	0	8347	680	24	4	892	4	KIF6	6	39507828	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4082127	39507828	131607239	200	42838											
DAAM2	23500	broad.mit.edu	37	chr6	39841095	39841095	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acacggaggcctacccctgcCtgctctctgtgctgcaccac	6	8	9	18	1	1	0	0	0	1	0	2	1	1	1	5	2	5	3	5	2	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:39841095C>G	uc003oow.2	+	10	1282	c.1126C>G	c.(1126-1128)CTG>GTG	p.L376V	DAAM2_uc010jxc.2_Missense_Mutation_p.L376V|DAAM2_uc003oox.2_Missense_Mutation_p.L376V	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	376	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CTACCCCTGCCTGCTCTCTGT	0.562													3	19					0	0	0	0	G	39841095	G	G	39841095	3	3	236	1	0	0	0	0	1	0	0	0	4233	680	24	4	1160	4	DAAM2	6	39841095	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	333267	39841095	131273972	201	42839											
TREML2	79865	broad.mit.edu	37	chr6	41165984	41165984	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttggcctgggcatcgtccTgcagcaagtagcggggccct	5	8	14	14	2	0	0	0	0	0	0	2	0	1	0	4	4	3	4	4	4	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:41165984T>C	uc010jxm.1	-	2	418	c.239A>G	c.(238-240)CAG>CGG	p.Q80R		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	80	Ig-like V-type.|Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGCATCGTCCTGCAGCAAGTA	0.582													22	108					0	0	0	0	C	41165984	C	C	41165984	3	2	236	1	0	0	0	0	1	0	0	0	16540	1580	55	5	742	5	TREML2	6	41165984	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	1324889	41165984	129949083	202	42840											
CUL7	9820	broad.mit.edu	37	chr6	43013126	43013126	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctctaacccccgaatgcgCgtatcaatgccaccctgaaa	12	8	6	15	3	2	1	1	1	1	0	3	2	2	1	4	0	3	1	4	0	5	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:43013126C>G	uc003otq.2	-	15	3180	c.2877G>C	c.(2875-2877)ACG>ACC	p.T959T	CUL7_uc010jyg.2_Silent_p.T238T|CUL7_uc011dvb.1_Silent_p.T1043T|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	959	DOC.				interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCCGAATGCGCGTATCAATGC	0.597													38	105					0	0	0	0	G	43013126	G	G	43013126	2	3	236	1	0	0	0	0	0	0	0	1	4077	755	27	3		3	CUL7	6	43013126	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1847142	43013126	128101941	203	42841											
CRISP3	10321	broad.mit.edu	37	chr6	49698934	49698935	+	Frame_Shift_Ins	INS	-	G	G																															aaggtgctccttgttcataaINSgggacatatagtctattagc																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:49698934_49698935insG	uc003ozs.2	-	7	566_567	c.551_552insC	c.(550-552)CCTfs	p.P184fs		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	184					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTTGTTCATAAGGGACATATAG	0.322													---	---	---								G	49698935	G	G	49698934	7	5	236	1	0	1	1	0	0	0	0	0	3896	59	3	0	193	0	CRISP3	6	49698934	Frame_Shift_Ins	INS	-	TCGA-CV-7245-01A-11D-2012-08	6685808	49698934	121416133	204	42842											
TFAP2B	7021	broad.mit.edu	37	chr6	50803949	50803949	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gttcagagacggctgtcgccCcctgaatgcctcaatgcatc	8	9	10	14	2	2	2	2	1	0	1	4	3	2	2	3	1	2	3	3	1	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:50803949C>G	uc003pag.2	+	4	943	c.777C>G	c.(775-777)CCC>CCG	p.P259P		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	259					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					GGCTGTCGCCCCCTGAATGCC	0.468													25	26					0	0	0	0	G	50803949	G	G	50803949	2	3	236	1	0	0	0	0	0	0	0	1	15854	610	22	4		4	TFAP2B	6	50803949	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1105015	50803949	120311118	205	42843											
PKHD1	5314	broad.mit.edu	37	chr6	51890545	51890545	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agcctccagactgtgaagagGgatggagcatccagacaggc	12	5	14	10	0	0	4	0	1	0	3	2	6	2	6	3	3	2	1	3	3	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:51890545G>A	uc003pah.1	-	32	4339	c.4063C>T	c.(4063-4065)CCT>TCT	p.P1355S	PKHD1_uc003pai.2_Missense_Mutation_p.P1355S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1355	IPT/TIG 8; atypical.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTGTGAAGAGGGATGGAGCAT	0.502													15	51					0	0	0	0	A	51890545	A	A	51890545	3	1	236	1	0	0	0	0	1	0	0	0	12026	1232	43	4	8344	4	PKHD1	6	51890545	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1086596	51890545	119224522	206	42844											
EYS	346007	broad.mit.edu	37	chr6	66044978	66044978	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccagcccatctgagaaaaCatagataccgatattcctga	14	9	7	11	1	1	3	0	2	1	2	2	5	2	3	4	0	4	0	4	0	5	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:66044978C>G	uc011dxu.1	-	11	2199	c.1661G>C	c.(1660-1662)TGT>TCT	p.C554S	EYS_uc003peq.2_Missense_Mutation_p.C554S|EYS_uc003per.1_Missense_Mutation_p.C554S	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	554					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TCTGAGAAAACATAGATACCG	0.348													14	33					0	0	0	0	G	66044978	G	G	66044978	3	3	236	1	0	0	0	0	1	0	0	0	5357	478	17	4	7867	4	EYS	6	66044978	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	14154433	66044978	105070089	207	42845											
COL12A1	1303	broad.mit.edu	37	chr6	75843070	75843070	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtataaacgggaactacagtCacagtgtatgaggtatctgg	13	10	12	6	1	2	1	1	1	1	0	2	2	2	2	0	3	3	3	0	3	7	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:75843070C>A	uc003phs.2	-	34	5899	c.5733G>T	c.(5731-5733)GTG>GTT	p.V1911V	COL12A1_uc003pht.2_Silent_p.V747V	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1911	Fibronectin type-III 14.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GAACTACAGTCACAGTGTATG	0.378													13	44					2.31682e-05	3.57162e-05	1	0	A	75843070	A	A	75843070	2	1	236	1	0	0	0	0	0	0	0	1	3684	813	29	2		2	COL12A1	6	75843070	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	9798092	75843070	95271997	208	42846											
IBTK	25998	broad.mit.edu	37	chr6	82911176	82911176	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaaagatccttcaaaacaCcatcgcttaaaacatcaaga	19	7	4	11	1	2	3	2	0	0	3	4	3	3	3	2	0	2	1	2	0	6	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:82911176C>G	uc003pjl.1	-	19	3280	c.2753G>C	c.(2752-2754)GGT>GCT	p.G918A	IBTK_uc011dyu.1_5'UTR|IBTK_uc011dyv.1_Missense_Mutation_p.G918A|IBTK_uc011dyw.1_Missense_Mutation_p.G717A|IBTK_uc010kbi.1_Missense_Mutation_p.G612A|IBTK_uc003pjm.2_Missense_Mutation_p.G918A	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	918					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		CTTCAAAACACCATCGCTTAA	0.318													11	13					0	0	0	0	G	82911176	G	G	82911176	3	3	236	1	0	0	0	0	1	0	0	0	7515	507	18	4	1352	4	IBTK	6	82911176	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	7068106	82911176	88203891	209	42847											
DOPEY1	23033	broad.mit.edu	37	chr6	83850121	83850121	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tattaatcttggagctacaaAggttagacaattcatattta	15	15	6	5	0	2	1	1	0	1	1	2	2	2	2	0	2	2	2	0	2	8	9			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:83850121A>G	uc003pjs.1	+	23	5674	c.5414A>G	c.(5413-5415)AAG>AGG	p.K1805R	DOPEY1_uc011dyy.1_Missense_Mutation_p.K1796R|DOPEY1_uc010kbl.1_Missense_Mutation_p.K1796R|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1805					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		GGAGCTACAAAGGTTAGACAA	0.378													15	41					0	0	0	0	G	83850121	G	G	83850121	3	3	236	1	0	0	0	0	1	0	0	0	4729	86	3	5	5496	5	DOPEY1	6	83850121	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	938945	83850121	87264946	210	42848											
GABRR2	2570	broad.mit.edu	37	chr6	89975369	89975369	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcacagctctgcggtcgatCcagaaggacacccaggacag	11	4	13	13	2	1	1	0	0	1	1	3	4	2	3	2	4	2	2	2	4	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:89975369C>A	uc003pnb.2	-	7	935	c.927G>T	c.(925-927)TGG>TGT	p.W309C	GABRR2_uc011dzx.1_Missense_Mutation_p.W185C	NM_002043	NP_002034	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 2	309					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		TGCGGTCGATCCAGAAGGACA	0.453													22	37					4.4004e-07	7.16616e-07	1	0	A	89975369	A	A	89975369	3	1	236	1	0	0	0	0	1	0	0	0	6211	856	30	2	557	2	GABRR2	6	89975369	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	6125248	89975369	81139698	211	42849											
FUT9	10690	broad.mit.edu	37	chr6	96651163	96651163	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagtccaatggaatcagcCagctctgtgctgaaaatgaa	13	10	9	9	0	3	2	2	2	1	0	4	3	4	3	2	1	3	2	2	1	5	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:96651163C>A	uc003pop.3	+	3	473	c.132C>A	c.(130-132)GCC>GCA	p.A44A		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	44	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		TGGAATCAGCCAGCTCTGTGC	0.403													32	34					1.62565e-12	2.92915e-12	1	0	A	96651163	A	A	96651163	2	1	236	1	0	0	0	0	0	0	0	1	6145	581	21	4		4	FUT9	6	96651163	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	6675794	96651163	74463904	212	42850											
KLHL32	114792	broad.mit.edu	37	chr6	97562042	97562042	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccatgcctgtgggaaggagCcaccattgtgtggcagtcat	8	9	13	11	0	1	0	1	0	0	0	1	2	1	2	4	3	2	1	4	3	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:97562042C>T	uc010kcm.1	+	7	1483	c.1011C>T	c.(1009-1011)AGC>AGT	p.S337S	KLHL32_uc003poy.2_Silent_p.S337S|KLHL32_uc011ead.1_Silent_p.S301S|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Silent_p.S268S|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	337	Kelch 1.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		TGGGAAGGAGCCACCATTGTG	0.562													16	70					0	0	0	0	T	97562042	T	T	97562042	2	4	236	1	0	0	0	0	0	0	0	1	8425	738	26	4		4	KLHL32	6	97562042	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	910879	97562042	73553025	213	42851											
POPDC3	64208	broad.mit.edu	37	chr6	105609578	105609578	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcagctgcacagacatctacCcaagcccagacagcagaaca	15	4	7	15	0	2	3	1	0	1	3	2	3	2	3	2	0	6	3	2	0	3	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:105609578C>G	uc003prb.2	-	2	609	c.207G>C	c.(205-207)TGG>TGC	p.W69C	uc003pqz.2_Intron|POPDC3_uc003pra.2_Intron	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	69	Helical; (Potential).					integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				AGACATCTACCCAAGCCCAGA	0.428													33	118					0	0	0	0	G	105609578	G	G	105609578	3	3	236	1	0	0	0	0	1	0	0	0	12311	624	22	4	680	4	POPDC3	6	105609578	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	8047536	105609578	65505489	214	42852											
PREP	5550	broad.mit.edu	37	chr6	105821390	105821390	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgaacttgattgtcaccCagtctgagccactggcactc	9	11	8	13	0	3	3	2	3	1	0	4	3	3	3	2	1	2	1	2	1	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:105821390C>A	uc003prc.2	-	5	652	c.449G>T	c.(448-450)TGG>TTG	p.W150L		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	150					proteolysis		serine-type endopeptidase activity	p.W150*(1)		ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	GATTGTCACCCAGTCTGAGCC	0.473													15	47					0.00244969	0.00361201	1	0	A	105821390	A	A	105821390	3	1	236	1	0	0	0	0	1	0	0	0	12536	595	21	4	1727	4	PREP	6	105821390	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	211812	105821390	65293677	215	42853											
LAMA4	3910	broad.mit.edu	37	chr6	112457395	112457395	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgcacagggccaccgctgAatccaaaatcatagaacaca	16	5	8	12	1	1	2	1	1	0	1	2	3	2	2	3	1	2	2	3	1	5	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:112457395A>C	uc003pvu.2	-	25	3653	c.3344T>G	c.(3343-3345)TTC>TGC	p.F1115C	LAMA4_uc003pvv.2_Missense_Mutation_p.F1108C|LAMA4_uc003pvt.2_Missense_Mutation_p.F1108C	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1115	Laminin G-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GCCACCGCTGAATCCAAAATC	0.378													3	45					0	0	0	0	C	112457395	C	C	112457395	3	2	236	1	0	0	0	0	1	0	0	0	8648	246	9	5	2187	5	LAMA4	6	112457395	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	6636005	112457395	58657672	216	42854											
LAMA4	3910	broad.mit.edu	37	chr6	112486448	112486448	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagagacatgttcaccacttCcatttgttccctcactcttt	8	15	4	14	0	3	1	2	0	1	1	5	2	5	1	3	0	0	2	3	0	0	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:112486448C>T	uc003pvu.2	-	13	1891	c.1582G>A	c.(1582-1584)GAA>AAA	p.E528K	LAMA4_uc003pvv.2_Missense_Mutation_p.E521K|LAMA4_uc003pvt.2_Missense_Mutation_p.E521K	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	528	Potential.|Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTCACCACTTCCATTTGTTCC	0.453													19	64					0	0	0	0	T	112486448	T	T	112486448	3	4	236	1	0	0	0	0	1	0	0	0	8648	864	30	2	3997	2	LAMA4	6	112486448	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	29053	112486448	58628619	217	42855											
ROS1	6098	broad.mit.edu	37	chr6	117680986	117680986	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatacctcagagctagagcGattgtgcaagtgcagaagaa	16	7	11	7	1	1	4	1	0	0	4	1	5	1	4	1	0	5	3	1	0	6	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:117680986G>T	uc003pxp.1	-	23	3833	c.3634C>A	c.(3634-3636)CGC>AGC	p.R1212S	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1212	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GAGCTAGAGCGATTGTGCAAG	0.393			T	GOPC|ROS1	glioblastoma|NSCLC								29	39					1.88708e-17	3.66229e-17	1	0	T	117680986	T	T	117680986	3	4	236	1	0	0	0	0	1	0	0	0	13596	1058	37	3	3493	3	ROS1	6	117680986	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	5194538	117680986	53434081	218	42856											
C6orf170	221322	broad.mit.edu	37	chr6	121562642	121562642	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcaatgccacctgctgcTgttgatgccactcgtgtaac	8	11	10	12	1	0	1	0	1	0	0	1	1	0	1	3	0	6	5	3	0	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:121562642T>A	uc003pyo.1	-	19	2282	c.2214A>T	c.(2212-2214)ACA>ACT	p.T738T	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_Silent_p.T257T	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	738					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		CACCTGCTGCTGTTGATGCCA	0.333													8	28					0	0	0	0	A	121562642	A	A	121562642	2	1	236	1	0	0	0	0	0	0	0	1	2354	1567	55	5		5	C6orf170	6	121562642	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	3881656	121562642	49552425	219	42857											
TRDN	10345	broad.mit.edu	37	chr6	123869599	123869599	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatctctatgttctttgtacCtttatcagtatcttcgtcac	7	20	4	10	1	5	0	2	0	3	0	7	0	5	0	1	0	1	3	1	0	5	9			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:123869599C>G	uc003pzj.1	-	3	413	c.391G>C	c.(391-393)GGA>CGA	p.G131R	TRDN_uc003pzk.1_Missense_Mutation_p.G131R|TRDN_uc003pzl.1_Missense_Mutation_p.G131R|TRDN_uc010ken.2_Missense_Mutation_p.G131R|TRDN_uc010keo.1_Missense_Mutation_p.G131R	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	131	Lumenal.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		TTCTTTGTACCTTTATCAGTA	0.368													3	6					0	0	0	0	G	123869599	G	G	123869599	3	3	236	1	0	0	0	0	1	0	0	0	16535	695	24	4	1954	4	TRDN	6	123869599	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2306957	123869599	47245468	220	42858											
EYA4	2070	broad.mit.edu	37	chr6	133836544	133836544	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattcctggctaacaaatgcActtaagtctttatcaattat	13	15	5	8	0	2	0	1	0	1	0	3	1	3	0	1	1	2	2	1	1	6	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:133836544A>T	uc003qec.3	+	17	2045	c.1587A>T	c.(1585-1587)GCA>GCT	p.A529A	EYA4_uc011ecq.1_Silent_p.A475A|EYA4_uc011ecr.1_Silent_p.A481A|EYA4_uc003qed.3_Silent_p.A529A|EYA4_uc003qee.3_Silent_p.A506A|EYA4_uc011ecs.1_Silent_p.A535A|uc003qeg.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	529					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TAACAAATGCACTTAAGTCTT	0.393													35	121					0	0	0	0	T	133836544	T	T	133836544	2	4	236	1	0	0	0	0	0	0	0	1	5356	146	6	5		5	EYA4	6	133836544	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	9966945	133836544	37278523	221	42859											
C6orf97	80129	broad.mit.edu	37	chr6	151917620	151917620	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccatcaggaacttgcagAagaaggtggagaggctgcag	13	7	14	7	0	1	3	1	0	0	3	1	5	1	4	1	4	4	3	1	4	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:151917620A>C	uc003qol.2	+	9	1707	c.1618A>C	c.(1618-1620)AAG>CAG	p.K540Q		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	540	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		GAACTTGCAGAAGAAGGTGGA	0.562													21	74					0	0	0	0	C	151917620	C	C	151917620	3	2	236	1	0	0	0	0	1	0	0	0	2385	247	9	5	1652	5	C6orf97	6	151917620	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	18081076	151917620	19197447	222	42860											
SYNE1	23345	broad.mit.edu	37	chr6	152443676	152443676	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcctctgacattggtacaagGcaggcaagcccgatgaggag	11	7	13	10	1	1	2	0	2	1	0	2	4	2	3	2	4	2	3	2	4	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:152443676G>T	uc010kiw.2	-	146	26891	c.26289C>A	c.(26287-26289)TGC>TGA	p.C8763*	SYNE1_uc010kiv.2_Nonsense_Mutation_p.C3287*|SYNE1_uc003qos.3_Nonsense_Mutation_p.C3287*|SYNE1_uc003qot.3_Nonsense_Mutation_p.C8715*|SYNE1_uc003qou.3_Nonsense_Mutation_p.C8763*|SYNE1_uc003qop.3_Nonsense_Mutation_p.C948*|SYNE1_uc011eez.1_3'UTR|SYNE1_uc003qoq.3_3'UTR|SYNE1_uc003qor.3_3'UTR	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8763	Helical; Anchor for type IV membrane protein; (Potential).|KASH.			Missing: Abolishes the nuclear envelope targeting, induces a cytoplasmic localization.	cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTGGTACAAGGCAGGCAAGCC	0.602										HNSCC(10;0.0054)			14	60					9.31168e-06	1.45375e-05	1	0	T	152443676	T	T	152443676	4	4	236	1	0	0	0	0	0	1	0	0	15511	1195	42	4	108	4	SYNE1	6	152443676	Nonsense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	526056	152443676	18671391	223	42861											
SYNE1	23345	broad.mit.edu	37	chr6	152456317	152456317	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatttcatttttccttctGtcaatgttctccagcataag	10	17	4	10	0	4	0	2	0	2	0	6	0	5	0	2	0	1	2	2	0	3	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:152456317G>T	uc010kiw.2	-	142	26312	c.25710C>A	c.(25708-25710)GAC>GAA	p.D8570E	SYNE1_uc010kiv.2_Missense_Mutation_p.D3094E|SYNE1_uc003qos.3_Missense_Mutation_p.D3094E|SYNE1_uc003qot.3_Missense_Mutation_p.D8522E|SYNE1_uc003qou.3_Missense_Mutation_p.D8570E|SYNE1_uc003qop.3_Missense_Mutation_p.D755E|SYNE1_uc011eez.1_Missense_Mutation_p.D772E|SYNE1_uc003qoq.3_Missense_Mutation_p.D772E|SYNE1_uc003qor.3_Missense_Mutation_p.D1493E	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8570	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTTCCTTCTGTCAATGTTCT	0.353										HNSCC(10;0.0054)			16	21					6.31663e-08	1.04426e-07	1	0	T	152456317	T	T	152456317	3	4	236	1	0	0	0	0	1	0	0	0	15511	1368	48	4	703	4	SYNE1	6	152456317	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	12641	152456317	18658750	224	42862											
SLC22A1	6580	broad.mit.edu	37	chr6	160557345	160557345	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcgctcaaaagaatgggaaGttgcctcctgctgatttaaa	13	11	9	8	1	1	2	1	1	0	1	3	3	2	3	2	1	2	3	2	1	6	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr6:160557345G>A	uc003qtc.2	+	5	1038	c.933G>A	c.(931-933)AAG>AAA	p.K311K	SLC22A1_uc003qtd.2_Silent_p.K311K	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	311	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		AGAATGGGAAGTTGCCTCCTG	0.498													22	40					0	0	0	0	A	160557345	A	A	160557345	2	1	236	1	0	0	0	0	0	0	0	1	14505	1020	36	4		4	SLC22A1	6	160557345	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	8101028	160557345	10557722	225	42863											
UNCX	340260	broad.mit.edu	37	chr7	1273324	1273324	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctagacctggtcgagtcccGagttcaggtaaagacccggc	9	7	12	13	3	1	2	1	0	0	2	3	4	2	2	4	3	0	2	4	3	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:1273324G>T	uc011jvw.1	+	2	443	c.443G>T	c.(442-444)CGA>CTA	p.R148L		NM_001080461	NP_001073930	A6NJT0	UNC4_HUMAN	UNC homeobox	148	Homeobox.				cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GTCGAGTCCCGAGTTCAGGTA	0.657													21	41					6.33239e-15	1.19355e-14	1	0	T	1273324	T	T	1273324	3	4	236	1	0	0	0	0	1	0	0	0	17066	1058	37	3	449	3	UNCX	7	1273324	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08		1273324	157865339	226	42864											
MAD1L1	8379	broad.mit.edu	37	chr7	1937910	1937910	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggttctccgtggtgatgtCgatctggtagccggtgagcg	4	12	16	9	4	2	2	0	2	2	0	4	3	2	2	2	4	2	2	2	4	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:1937910C>T	uc003slh.1	-	18	2190	c.1924G>A	c.(1924-1926)GAC>AAC	p.D642N	MAD1L1_uc003sle.1_Missense_Mutation_p.D371N|MAD1L1_uc003slf.1_Missense_Mutation_p.D642N|MAD1L1_uc003slg.1_Missense_Mutation_p.D642N|MAD1L1_uc010ksh.1_Missense_Mutation_p.D642N|MAD1L1_uc003sli.1_Missense_Mutation_p.D550N|MAD1L1_uc010ksi.1_Missense_Mutation_p.D595N|MAD1L1_uc010ksj.2_Missense_Mutation_p.D642N|MAD1L1_uc003sld.1_Missense_Mutation_p.D98N	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	642					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		GTGGTGATGTCGATCTGGTAG	0.612													18	38					0	0	0	0	T	1937910	T	T	1937910	3	4	236	1	0	0	0	0	1	0	0	0	9198	884	31	1	240	1	MAD1L1	7	1937910	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	664586	1937910	157200753	227	42865											
THSD7A	221981	broad.mit.edu	37	chr7	11486919	11486919	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cattgcatgaagaaaacttgGaccagctggtcaattgacag	14	9	10	8	0	1	3	1	2	0	1	1	4	1	4	1	2	3	2	1	2	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:11486919G>T	uc003ssf.3	-	12	2990	c.2738C>A	c.(2737-2739)TCC>TAC	p.S913Y		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	913	TSP type-1 9.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		AGAAAACTTGGACCAGCTGGT	0.522										HNSCC(18;0.044)			12	27					7.03913e-09	1.18566e-08	1	0	T	11486919	T	T	11486919	3	4	236	1	0	0	0	0	1	0	0	0	15945	1174	41	2	2299	2	THSD7A	7	11486919	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	9549009	11486919	147651744	228	42866											
THSD7A	221981	broad.mit.edu	37	chr7	11676130	11676130	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgccaccacatgacgcgtccGgtgctggagcccgctgccgc	5	5	13	18	6	0	1	0	1	0	0	1	2	1	2	5	2	3	2	5	2	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:11676130G>T	uc003ssf.3	-	2	901	c.649C>A	c.(649-651)CGG>AGG	p.R217R		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	217	Extracellular (Potential).|TSP type-1 2.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TGACGCGTCCGGTGCTGGAGC	0.617										HNSCC(18;0.044)			5	30					1.23904e-05	1.92522e-05	1	0	T	11676130	T	T	11676130	2	4	236	1	0	0	0	0	0	0	0	1	15945	1115	39	3		3	THSD7A	7	11676130	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	189211	11676130	147462533	229	42867											
CREB5	9586	broad.mit.edu	37	chr7	28844011	28844011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaccagcacccagcacacCatcctcaccctcaaccccat	12	4	3	22	0	2	0	2	0	0	0	3	0	3	0	7	0	4	3	7	0	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:28844011C>T	uc003szq.2	+	8	1288	c.898C>T	c.(898-900)CAT>TAT	p.H300Y	CREB5_uc003szo.2_Missense_Mutation_p.H267Y|CREB5_uc003szr.2_Missense_Mutation_p.H293Y|CREB5_uc003szs.2_Missense_Mutation_p.H161Y	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	300					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						cccagcacaccatcctcaccc	0.114													22	22					0	0	0	0	T	28844011	T	T	28844011	3	4	236	1	0	0	0	0	1	0	0	0	3875	594	21	4	979	4	CREB5	7	28844011	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	17167881	28844011	130294652	230	42868											
KIAA0895	23366	broad.mit.edu	37	chr7	36397151	36397151	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatcaatgaatcttctgcaTttagaatagacttcttagca	13	15	6	7	0	4	4	1	2	3	2	4	4	4	4	0	0	2	2	0	0	6	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:36397151T>C	uc003tfd.2	-	3	278	c.227A>G	c.(226-228)AAT>AGT	p.N76S	KIAA0895_uc003tfc.2_Missense_Mutation_p.N63S|KIAA0895_uc011kaw.1_5'UTR|KIAA0895_uc003tfb.2_Missense_Mutation_p.N25S|KIAA0895_uc011kax.1_Missense_Mutation_p.N25S|KIAA0895_uc003tfe.2_Missense_Mutation_p.N63S|KIAA0895_uc011kay.1_Missense_Mutation_p.N25S	NM_001100425	NP_001093895	Q8NCT3	K0895_HUMAN	hypothetical protein LOC23366 isoform 1	76											0						ATCTTCTGCATTTAGAATAGA	0.343													9	23					0	0	0	0	C	36397151	C	C	36397151	3	2	236	1	0	0	0	0	1	0	0	0	8236	1493	52	5	1355	5	KIAA0895	7	36397151	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	7553140	36397151	122741512	231	42869											
ELMO1	9844	broad.mit.edu	37	chr7	36895281	36895281	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccatgctgagcagggtgtCcaggtcattccgcgtcaggt	6	11	13	11	2	2	1	2	1	0	0	5	1	5	1	3	3	2	2	3	3	0	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:36895281C>A	uc003tfk.1	-	22	2366	c.2059G>T	c.(2059-2061)GAC>TAC	p.D687Y	ELMO1_uc003tfi.1_Missense_Mutation_p.D207Y|ELMO1_uc003tfj.1_Missense_Mutation_p.D207Y|ELMO1_uc011kbb.1_RNA|ELMO1_uc011kbc.1_Missense_Mutation_p.D591Y|ELMO1_uc010kxg.1_Missense_Mutation_p.D687Y	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	687					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						AGCAGGGTGTCCAGGTCATTC	0.577													39	99					2.59497e-14	4.81713e-14	1	0	A	36895281	A	A	36895281	3	1	236	1	0	0	0	0	1	0	0	0	5089	855	30	2	128	2	ELMO1	7	36895281	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	498130	36895281	122243382	232	42870											
PKD1L1	168507	broad.mit.edu	37	chr7	47898472	47898472	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaggatgagaaccgcactCataaagcctagctgcatgaa	14	8	10	9	1	1	3	1	3	0	1	1	5	1	4	2	1	4	3	2	1	5	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:47898472C>G	uc003tny.1	-	27	4161	c.4161G>C	c.(4159-4161)ATG>ATC	p.M1387I		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1387	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GAACCGCACTCATAAAGCCTA	0.498													9	26					0	0	0	0	G	47898472	G	G	47898472	3	3	236	1	0	0	0	0	1	0	0	0	12019	826	29	2	4512	2	PKD1L1	7	47898472	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	11003191	47898472	111240191	233	42871											
FIGNL1	63979	broad.mit.edu	37	chr7	50514817	50514817	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatattttttgaacagttTggtagcacagacctgggaaa	12	13	10	6	0	0	2	0	1	0	1	0	3	0	3	1	2	3	4	1	2	4	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:50514817T>A	uc003tpc.2	-	4	546	c.169A>T	c.(169-171)AAA>TAA	p.K57*	FIGNL1_uc003tpb.2_Intron|FIGNL1_uc003tpd.2_Nonsense_Mutation_p.K57*|FIGNL1_uc003tpe.2_Nonsense_Mutation_p.K57*|FIGNL1_uc010kyy.2_Nonsense_Mutation_p.K57*	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	57					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				TTGAACAGTTTGGTAGCACAG	0.393													15	42					0	0	0	0	A	50514817	A	A	50514817	4	1	236	1	0	0	0	0	0	1	0	0	5924	1821	63	5	1859	5	FIGNL1	7	50514817	Nonsense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2616345	50514817	108623846	234	42872											
WBSCR17	64409	broad.mit.edu	37	chr7	70853353	70853353	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgcccacacacctgctgaaGgaaatcattctggtggatga	12	8	10	11	1	2	2	1	2	1	0	2	4	2	4	2	3	1	1	2	3	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:70853353G>A	uc003tvy.2	+	3	555	c.555G>A	c.(553-555)AAG>AAA	p.K185K	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	185	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				ACCTGCTGAAGGAAATCATTC	0.542													17	27					0	0	0	0	A	70853353	A	A	70853353	2	1	236	1	0	0	0	0	0	0	0	1	17332	991	35	4		4	WBSCR17	7	70853353	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	20338536	70853353	88285310	235	42873											
LAT2	7462	broad.mit.edu	37	chr7	73638999	73638999	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagaagcatcccctggccCggtgggaagcccagacgagg	10	3	16	12	2	0	2	0	0	0	2	1	6	1	3	4	4	2	1	4	4	2	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:73638999C>T	uc003uag.2	+	13	1209	c.659C>T	c.(658-660)CCG>CTG	p.P220L	RFC2_uc011kfa.1_Intron|LAT2_uc003uah.2_Missense_Mutation_p.P220L|LAT2_uc003uai.2_Missense_Mutation_p.P220L|LAT2_uc010lbo.2_RNA	NM_032464	NP_115853	Q9GZY6	NTAL_HUMAN	linker for activation of T cells family member	220	Cytoplasmic (Potential).				B cell activation|B cell receptor signaling pathway|calcium-mediated signaling|mast cell degranulation	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding				0						TCCCCTGGCCCGGTGGGAAGC	0.612													6	6					0	0	0	0	T	73638999	T	T	73638999	3	4	236	1	0	0	0	0	1	0	0	0	8685	652	23	1	701	1	LAT2	7	73638999	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2785646	73638999	85499664	236	42874											
SEMA3C	10512	broad.mit.edu	37	chr7	80394488	80394488	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaccttaaagacttccagctCctccagaatgagctcgccac	12	8	6	15	1	0	3	0	1	0	2	4	3	3	3	5	0	3	2	5	0	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:80394488C>G	uc003uhj.2	-	13	1988	c.1426G>C	c.(1426-1428)GAG>CAG	p.E476Q	SEMA3C_uc011kgw.1_Missense_Mutation_p.E494Q	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	476	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						ACTTCCAGCTCCTCCAGAATG	0.388													23	49					0	0	0	0	G	80394488	G	G	80394488	3	3	236	1	0	0	0	0	1	0	0	0	14091	864	30	2	853	2	SEMA3C	7	80394488	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	6755489	80394488	78744175	237	42875											
HGF	3082	broad.mit.edu	37	chr7	81388078	81388078	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttgacatgctattgaagggGaaccagaggcattgttttct	10	13	11	7	0	1	3	0	2	1	1	1	4	1	4	1	3	2	3	1	3	3	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:81388078G>T	uc003uhl.2	-	3	462	c.297C>A	c.(295-297)TTC>TTA	p.F99L	HGF_uc003uhm.2_Missense_Mutation_p.F99L|HGF_uc003uhn.1_Missense_Mutation_p.F99L|HGF_uc003uho.1_Missense_Mutation_p.F99L|HGF_uc003uhp.2_Missense_Mutation_p.F99L	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	99	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						TATTGAAGGGGAACCAGAGGC	0.318													36	59					6.5261e-18	1.27662e-17	1	0	T	81388078	T	T	81388078	3	4	236	1	0	0	0	0	1	0	0	0	7124	1165	41	2	1973	2	HGF	7	81388078	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	993590	81388078	77750585	238	42876											
GRM3	2913	broad.mit.edu	37	chr7	86394734	86394734	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgctaccaggagtgaagttGggtgttcacattttggatac	9	14	12	6	0	1	1	1	1	0	0	1	3	1	3	1	3	3	3	1	3	3	7	rs150518450		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:86394734G>C	uc003uid.2	+	2	1372	c.273G>C	c.(271-273)TTG>TTC	p.L91F	GRM3_uc010lef.2_Missense_Mutation_p.L89F|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	91	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GAGTGAAGTTGGGTGTTCACA	0.433													31	126					0	0	0	0	C	86394734	C	C	86394734	3	2	236	1	0	0	0	0	1	0	0	0	6837	1339	47	4	275	4	GRM3	7	86394734	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	5006656	86394734	72743929	239	42877											
AKAP9	10142	broad.mit.edu	37	chr7	91631454	91631454	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaaagaaaagggtacactTgaacaagaagttcaagaatt	21	7	9	4	0	1	4	1	1	0	3	1	5	1	4	0	1	2	2	0	1	10	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:91631454T>G	uc003ulg.2	+	8	2448	c.2223T>G	c.(2221-2223)CTT>CTG	p.L741L	AKAP9_uc003ule.2_Silent_p.L753L|AKAP9_uc003ulf.2_Silent_p.L741L|AKAP9_uc003uli.2_Silent_p.L366L	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	753	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGGGTACACTTGAACAAGAAG	0.294			T	BRAF	papillary thyroid								10	53					0	0	0	0	G	91631454	G	G	91631454	2	3	236	1	0	0	0	0	0	0	0	1	459	1799	63	5		5	AKAP9	7	91631454	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	5236720	91631454	67507209	240	42878											
DYNC1I1	1780	broad.mit.edu	37	chr7	95668588	95668588	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcatgtgtgctcttcctacaGcaaagcaggtattggtgagg	9	12	12	8	0	2	1	1	1	1	0	3	1	3	1	1	3	4	4	1	3	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:95668588G>T	uc003uoc.3	+	14	1693	c.1416_splice	c.e14-1	p.S472_splice	DYNC1I1_uc003uod.3_Splice_Site_p.S455_splice|DYNC1I1_uc003uob.2_Splice_Site_p.S435_splice|DYNC1I1_uc003uoe.3_Splice_Site_p.S452_splice|DYNC1I1_uc010lfl.2_Splice_Site_p.S461_splice	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1						vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TCTTCCTACAGCAAAGCAGGT	0.448													33	161					2.49991e-28	5.15739e-28	1	0	T	95668588	T	T	95668588	5	4	236	1	0	0	0	0	0	0	1	0	4864	985	34	4	1465	4	DYNC1I1	7	95668588	Splice_Site	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4037134	95668588	63470075	241	42879											
MUC17	140453	broad.mit.edu	37	chr7	100677500	100677500	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtatgcctgacagcaccacgCcggtagtcagttctgaggct	8	9	12	12	2	2	2	1	2	1	0	2	2	2	2	3	2	2	5	3	2	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:100677500C>A	uc003uxp.1	+	3	2856	c.2803C>A	c.(2803-2805)CCG>ACG	p.P935T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	935	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|13.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGCACCACGCCGGTAGTCAG	0.517													130	553					1.03418e-33	2.15162e-33	1	0	A	100677500	A	A	100677500	3	1	236	1	0	0	0	0	1	0	0	0	10027	739	26	4	2813	4	MUC17	7	100677500	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5008912	100677500	58461163	242	42880											
RELN	5649	broad.mit.edu	37	chr7	103130227	103130227	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgcagatggcaccggtcGtgcagtatccgtgcccgctg	7	8	14	12	4	0	2	0	0	0	2	2	2	1	2	3	2	3	5	3	2	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:103130227G>T	uc003vca.2	-	60	9885	c.9725C>A	c.(9724-9726)ACG>AAG	p.T3242K	RELN_uc010liz.2_Missense_Mutation_p.T3242K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3242	EGF-like 8.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGCACCGGTCGTGCAGTATCC	0.458													10	36					7.48243e-07	1.2125e-06	1	0	T	103130227	T	T	103130227	3	4	236	1	0	0	0	0	1	0	0	0	13285	1145	40	3	681	3	RELN	7	103130227	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2452727	103130227	56008436	243	42881											
RINT1	60561	broad.mit.edu	37	chr7	105177012	105177012	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgttattcttttgttgtagGtgacataaatgttacagttc	9	20	8	4	0	1	1	0	1	1	0	2	1	1	1	0	1	1	5	0	1	5	10			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:105177012G>A	uc003vda.1	+	3	320	c.89G>A	c.(88-90)AGT>AAT	p.S30N	RINT1_uc010ljj.1_Translation_Start_Site	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	30					cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						TTTGTTGTAGGTGACATAAAT	0.318													43	52					0	0	0	0	A	105177012	A	A	105177012	3	1	236	1	0	0	0	0	1	0	0	0	13441	1275	44	4	99	4	RINT1	7	105177012	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2046785	105177012	53961651	244	42882											
PIK3CG	5294	broad.mit.edu	37	chr7	106508711	106508711	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagccagaccattaaggtCtcacccgacgacacccccgg	11	4	8	18	3	1	1	1	0	1	1	2	3	1	1	6	2	1	0	6	2	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:106508711C>G	uc003vdv.3	+	2	790	c.705C>G	c.(703-705)GTC>GTG	p.V235V	PIK3CG_uc003vdu.2_Silent_p.V235V|PIK3CG_uc003vdw.2_Silent_p.V235V	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	235					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CCATTAAGGTCTCACCCGACG	0.547													35	84					0	0	0	0	G	106508711	G	G	106508711	2	3	236	1	0	0	0	0	0	0	0	1	11971	900	32	2		2	PIK3CG	7	106508711	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1331699	106508711	52629952	245	42883											
LAMB1	3912	broad.mit.edu	37	chr7	107599899	107599899	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggattgcagaaggcattgaCagatccttgcagatggcact	11	9	13	8	0	0	4	0	1	0	3	1	5	1	5	1	3	2	4	1	3	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:107599899C>A	uc003vew.2	-	20	2820	c.2485G>T	c.(2485-2487)GTC>TTC	p.V829F	LAMB1_uc003vev.2_Missense_Mutation_p.V853F	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	829	Laminin EGF-like 7.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAGGCATTGACAGATCCTTGC	0.507													17	59					1.67942e-08	2.79998e-08	1	0	A	107599899	A	A	107599899	3	1	236	1	0	0	0	0	1	0	0	0	8650	478	17	4	2935	4	LAMB1	7	107599899	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1091188	107599899	51538764	246	42884											
RNF148	378925	broad.mit.edu	37	chr7	122342350	122342350	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggttgcttatcatcaccGcgactatattttccgtcccc	7	14	6	14	3	3	0	3	0	0	0	5	1	5	0	4	1	1	2	4	1	3	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:122342350G>A	uc003vkk.1	-	1	672	c.455C>T	c.(454-456)GCG>GTG	p.A152V	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron|RNF148_uc010lkr.1_Missense_Mutation_p.A54V	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	ring finger protein 148 precursor	152	PA.					integral to membrane	zinc ion binding				0						TATCATCACCGCGACTATATT	0.463													117	264					0	0	0	0	A	122342350	A	A	122342350	3	1	236	1	0	0	0	0	1	0	0	0	13514	1087	38	1	466	1	RNF148	7	122342350	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	14742451	122342350	36796313	247	42885											
PLXNA4	91584	broad.mit.edu	37	chr7	131866875	131866875	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cattgatgtgctccttccctCcatgcttggcacggatctgg	5	13	10	13	1	1	1	0	1	1	0	4	2	4	2	3	3	2	3	3	3	0	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:131866875C>T	uc003vra.3	-	17	3462	c.3233G>A	c.(3232-3234)GGA>GAA	p.G1078E		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1078	Extracellular (Potential).|IPT/TIG 3.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CTCCTTCCCTCCATGCTTGGC	0.557													24	37					0	0	0	0	T	131866875	T	T	131866875	3	4	236	1	0	0	0	0	1	0	0	0	12177	855	30	2	2515	2	PLXNA4	7	131866875	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	9524525	131866875	27271788	248	42886											
DGKI	9162	broad.mit.edu	37	chr7	137148340	137148340	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcgtttccgcagggcaggaTtccaccagtctgagatcctg	7	10	12	12	2	1	1	0	1	1	1	4	3	4	2	4	2	1	3	4	2	0	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:137148340T>C	uc003vtt.2	-	28	2655	c.2654A>G	c.(2653-2655)AAT>AGT	p.N885S	DGKI_uc003vtu.2_Intron	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	885					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CAGGGCAGGATTCCACCAGTC	0.502													24	30					0	0	0	0	C	137148340	C	C	137148340	3	2	236	1	0	0	0	0	1	0	0	0	4493	1493	52	5	571	5	DGKI	7	137148340	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	5281465	137148340	21990323	249	42887											
UBN2	254048	broad.mit.edu	37	chr7	138944065	138944065	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaagcggaagcggaaagAggaaggggaaaaggagaaga	20	0	19	2	2	0	4	0	0	0	4	0	10	0	8	0	6	2	0	0	6	8	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:138944065A>G	uc011kqr.1	+	5	854	c.854A>G	c.(853-855)GAG>GGG	p.E285G	UBN2_uc003vuv.2_Missense_Mutation_p.E8G	NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	285	Lys-rich.									ovary(1)|skin(1)	2						AAGCGGAAAGAGGAAGGGGAA	0.388													10	63					0	0	0	0	G	138944065	G	G	138944065	3	3	236	1	0	0	0	0	1	0	0	0	16961	304	11	5	872	5	UBN2	7	138944065	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	1795725	138944065	20194598	250	42888											
BRAF	673	broad.mit.edu	37	chr7	140482832	140482832	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactcttaccattcgattccTgtcttctgaggatgaagatg	9	15	8	9	1	3	3	0	2	3	1	5	5	4	4	2	1	2	0	2	1	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:140482832T>G	uc003vwc.3	-	10	1364	c.1303A>C	c.(1303-1305)AGG>CGG	p.R435R		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	435					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	ATTCGATTCCTGTCTTCTGAG	0.388		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				16	30					0	0	0	0	G	140482832	G	G	140482832	2	3	236	1	0	0	0	0	0	0	0	1	1501	1579	55	5		5	BRAF	7	140482832	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	1538767	140482832	18655831	251	42889											
TRPV5	56302	broad.mit.edu	37	chr7	142625329	142625329	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatcaggtgctggaacaTctgagagaccaccaggatga	12	7	12	10	0	2	3	1	2	1	1	2	6	2	5	2	3	3	2	2	3	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:142625329T>C	uc003wby.1	-	7	1027	c.763A>G	c.(763-765)ATG>GTG	p.M255V	TRPV5_uc003wbz.2_Missense_Mutation_p.M255V	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	255	ANK 5.|Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					TGCTGGAACATCTGAGAGACC	0.567													13	93					0	0	0	0	C	142625329	C	C	142625329	3	2	236	1	0	0	0	0	1	0	0	0	16666	1449	50	5	1462	5	TRPV5	7	142625329	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2142497	142625329	16513334	252	42890											
KEL	3792	broad.mit.edu	37	chr7	142640671	142640671	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	taagcattgacgtcccaaggGgacaccttccacctgtggga	10	8	11	12	1	0	1	0	1	0	0	2	3	2	3	4	3	1	1	4	3	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:142640671G>T	uc003wcb.2	-	15	1815	c.1605C>A	c.(1603-1605)TCC>TCA	p.S535S		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	535	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					CGTCCCAAGGGGACACCTTCC	0.552													13	57					2.68362e-12	4.80021e-12	1	0	T	142640671	T	T	142640671	2	4	236	1	0	0	0	0	0	0	0	1	8181	1219	43	4		4	KEL	7	142640671	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	15342	142640671	16497992	253	42891											
TAS2R41	259287	broad.mit.edu	37	chr7	143175187	143175187	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactactctgcccagaaggtCgagtactctgggggtctcgg	7	10	13	11	2	3	1	0	0	3	1	5	2	3	1	1	4	4	1	1	4	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:143175187C>A	uc003wdc.1	+	1	222	c.222C>A	c.(220-222)GTC>GTA	p.V74V	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	74	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					CCCAGAAGGTCGAGTACTCTG	0.552													25	110					2.21704e-12	3.98013e-12	1	0	A	143175187	A	A	143175187	2	1	236	1	0	0	0	0	0	0	0	1	15645	871	31	3		3	TAS2R41	7	143175187	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	534516	143175187	15963476	254	42892											
OR2F1	26211	broad.mit.edu	37	chr7	143657334	143657334	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttcttgcagaacataaaGccatcccattccagagctgt	12	12	6	11	0	1	2	0	0	1	2	3	2	3	2	3	0	4	2	3	0	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:143657334G>T	uc003wds.1	+	1	315	c.271G>T	c.(271-273)GCC>TCC	p.A91S		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					AGAACATAAAGCCATCCCATT	0.502													49	178					7.77372e-23	1.5611e-22	1	0	T	143657334	T	T	143657334	3	4	236	1	0	0	0	0	1	0	0	0	11050	971	34	4	273	4	OR2F1	7	143657334	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	482147	143657334	15481329	255	42893											
VIPR2	7434	broad.mit.edu	37	chr7	158835786	158835786	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggagtagagaacgtcgtcCttgaccagcactgagatggc	10	8	13	10	2	0	3	0	2	0	2	2	6	1	4	2	2	2	2	2	2	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr7:158835786C>A	uc003woh.2	-	6	723	c.537G>T	c.(535-537)AAG>AAT	p.K179N	VIPR2_uc010lqx.2_RNA|VIPR2_uc010lqy.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	179	Extracellular (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		GAACGTCGTCCTTGACCAGCA	0.527													13	40					0.000151284	0.000228908	1	0	A	158835786	A	A	158835786	3	1	236	1	0	0	0	0	1	0	0	0	17238	680	24	4	811	4	VIPR2	7	158835786	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	15178452	158835786	302877	256	42894											
MYOM2	9172	broad.mit.edu	37	chr8	2044190	2044190	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtggtggctcgcccatcctGggctactacctggacaagcg	7	8	13	13	2	0	0	0	0	0	0	2	1	1	1	3	4	3	2	3	4	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:2044190G>T	uc003wpx.3	+	18	2367	c.2229G>T	c.(2227-2229)CTG>CTT	p.L743L	MYOM2_uc011kwi.1_Silent_p.L168L	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	743	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CGCCCATCCTGGGCTACTACC	0.532													13	60					1.5842e-08	2.65929e-08	1	0	T	2044190	T	T	2044190	2	4	236	1	0	0	0	0	0	0	0	1	10145	1335	47	4		4	MYOM2	8	2044190	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08		2044190	144319832	257	42895											
DLC1	10395	broad.mit.edu	37	chr8	13356615	13356615	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgggtggccagggtctcCtttaattgtaaacactgcat	8	13	10	10	0	1	0	0	0	1	0	3	0	2	0	3	3	2	2	3	3	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:13356615C>T	uc003wwm.2	-	2	1410	c.966G>A	c.(964-966)AAG>AAA	p.K322K	DLC1_uc003wwn.2_Silent_p.K322K|DLC1_uc011kxy.1_Silent_p.K322K	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	322					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CCAGGGTCTCCTTTAATTGTA	0.428													16	44					0	0	0	0	T	13356615	T	T	13356615	2	4	236	1	0	0	0	0	0	0	0	1	4572	680	24	4		4	DLC1	8	13356615	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	11312425	13356615	133007407	258	42896											
NUDT18	79873	broad.mit.edu	37	chr8	21965720	21965720	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagcagtgtctcgggctcAcagtgcagccccgcctcctc	6	7	11	17	2	2	0	1	0	1	0	5	1	3	0	4	1	3	3	4	1	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:21965720A>T	uc003xaq.1	-	5	419	c.300T>A	c.(298-300)TGT>TGA	p.C100*	NUDT18_uc003xar.1_3'UTR	NM_024815	NP_079091	Q6ZVK8	NUD18_HUMAN	nudix (nucleoside diphosphate linked moiety	100	Nudix hydrolase.						hydrolase activity|metal ion binding|protein binding				0				Colorectal(74;0.00185)|COAD - Colon adenocarcinoma(73;0.0608)|READ - Rectum adenocarcinoma(5;0.0986)		TCTCGGGCTCACAGTGCAGCC	0.697													3	22					0	0	0	0	T	21965720	T	T	21965720	4	4	236	1	0	0	0	0	0	1	0	0	10789	157	6	5	679	5	NUDT18	8	21965720	Nonsense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	8609105	21965720	124398302	259	42897											
DUSP4	1846	broad.mit.edu	37	chr8	29207392	29207392	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcagatgtcggtgcgctcgGcgttgcggcgcagcgcctgc	3	7	18	13	7	0	1	0	0	0	1	2	1	0	1	1	4	4	4	1	4	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:29207392G>A	uc003xhm.2	-	1	794	c.404C>T	c.(403-405)GCC>GTC	p.A135V	DUSP4_uc003xhl.2_5'Flank	NM_001394	NP_001385	Q13115	DUS4_HUMAN	dual specificity phosphatase 4 isoform 1	135	Rhodanese.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		GGTGCGCTCGGCGTTGCGGCG	0.687													13	16					0	0	0	0	A	29207392	A	A	29207392	3	1	236	1	0	0	0	0	1	0	0	0	4849	1203	42	4	960	4	DUSP4	8	29207392	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	7241672	29207392	117156630	260	42898											
ADAM2	2515	broad.mit.edu	37	chr8	39682336	39682336	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaagagatcataaaaaacatAcctgaaaatcttggtcaagt	20	9	6	6	0	3	2	2	1	1	1	3	3	3	2	1	1	2	0	1	1	8	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:39682336A>T	uc003xnj.2	-	4	342	c.267_splice	c.e4+1	p.Q89_splice	ADAM2_uc003xnk.2_Splice_Site_p.Q89_splice|ADAM2_uc011lck.1_Splice_Site_p.Q89_splice|ADAM2_uc003xnl.2_Splice_Site_p.Q89_splice	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein						cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TAAAAAACATACCTGAAAATC	0.318													6	30					0	0	0	0	T	39682336	T	T	39682336	5	4	236	1	0	0	0	0	0	0	1	0	241	405	14	5	2006	5	ADAM2	8	39682336	Splice_Site	SNP	A	TCGA-CV-7245-01A-11D-2012-08	10474944	39682336	106681686	261	42899											
ADAM2	2515	broad.mit.edu	37	chr8	39682401	39682401	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taactgtaaactctaaaattAtggggtaaaaagtttctgta	16	14	7	4	0	2	0	0	0	2	0	2	0	2	0	0	2	2	4	0	2	10	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:39682401A>T	uc003xnj.2	-	4	279	c.204T>A	c.(202-204)CAT>CAA	p.H68Q	ADAM2_uc003xnk.2_Missense_Mutation_p.H68Q|ADAM2_uc011lck.1_Missense_Mutation_p.H68Q|ADAM2_uc003xnl.2_Missense_Mutation_p.H68Q	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	68					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTCTAAAATTATGGGGTAAAA	0.269													13	33					0	0	0	0	T	39682401	T	T	39682401	3	4	236	1	0	0	0	0	1	0	0	0	241	446	16	5	2071	5	ADAM2	8	39682401	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	65	39682401	106681621	262	42900											
SNTG1	54212	broad.mit.edu	37	chr8	51449264	51449264	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatcatgctcgtcgtggccGacgtctccaggcttgaggtg	5	12	13	11	4	2	1	1	1	1	0	5	2	2	1	2	3	1	2	2	3	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:51449264G>T	uc010lxy.1	+	12	947	c.576G>T	c.(574-576)CCG>CCT	p.P192P	SNTG1_uc003xqs.1_Silent_p.P192P|SNTG1_uc010lxz.1_Silent_p.P192P|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	192					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CGTCGTGGCCGACGTCTCCAG	0.463													35	131					5.43694e-19	1.06781e-18	1	0	T	51449264	T	T	51449264	2	4	236	1	0	0	0	0	0	0	0	1	14938	1045	37	3		3	SNTG1	8	51449264	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	11766863	51449264	94914758	263	42901											
ST18	9705	broad.mit.edu	37	chr8	53045843	53045843	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcacgtgccccgagccatcGcagcctggggttggacacct	6	7	13	15	3	1	0	1	0	0	0	2	2	1	1	5	3	3	2	5	3	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:53045843G>A	uc003xqz.2	-	15	2475	c.2319C>T	c.(2317-2319)TGC>TGT	p.C773C	ST18_uc011ldq.1_Silent_p.C420C|ST18_uc011ldr.1_Silent_p.C738C|ST18_uc011lds.1_Silent_p.C678C|ST18_uc003xra.2_Silent_p.C773C	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	773	C2HC-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCGAGCCATCGCAGCCTGGGG	0.522													16	70					0	0	0	0	A	53045843	A	A	53045843	2	1	236	1	0	0	0	0	0	0	0	1	15278	1079	38	1		1	ST18	8	53045843	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1596579	53045843	93318179	264	42902											
RP1	6101	broad.mit.edu	37	chr8	55538431	55538431	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccaaaaaatgaaaagaaGattttgtcatctgttgccag	15	12	7	7	0	2	3	1	1	1	2	3	3	3	3	2	0	1	1	2	0	6	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:55538431G>T	uc003xsd.1	+	4	2137	c.1989G>T	c.(1987-1989)AAG>AAT	p.K663N	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	663			K -> N (in RP1; uncertain pathogenicity).		axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATGAAAAGAAGATTTTGTCAT	0.363													8	33					1.06961e-07	1.7594e-07	1	0	T	55538431	T	T	55538431	3	4	236	1	0	0	0	0	1	0	0	0	13597	933	33	2	1999	2	RP1	8	55538431	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2492588	55538431	90825591	265	42903											
ADHFE1	137872	broad.mit.edu	37	chr8	67357536	67357536	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggctctaccatggacacctGtaaggctgctaatctgtatg	9	12	10	10	0	2	0	0	0	2	0	2	1	2	1	2	3	2	5	2	3	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:67357536G>A	uc003xwb.3	+	6	471	c.437G>A	c.(436-438)TGT>TAT	p.C146Y	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Missense_Mutation_p.C98Y|ADHFE1_uc003xwe.3_RNA|ADHFE1_uc003xwf.3_Intron|ADHFE1_uc011les.1_Missense_Mutation_p.C76Y|ADHFE1_uc011leq.1_Intron|ADHFE1_uc011ler.1_Intron	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	146					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			ATGGACACCTGTAAGGCTGCT	0.478													35	116					0	0	0	0	A	67357536	A	A	67357536	3	1	236	1	0	0	0	0	1	0	0	0	314	1377	48	4	459	4	ADHFE1	8	67357536	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	11819105	67357536	79006486	266	42904											
LRRCC1	85444	broad.mit.edu	37	chr8	86042283	86042283	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacttcttgcattgaaagaaCaggaacacaggtaaatgaaa	19	8	8	6	0	1	3	0	2	1	1	1	4	1	4	0	2	4	2	0	2	7	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:86042283C>A	uc003ycw.2	+	11	1910	c.1756C>A	c.(1756-1758)CAG>AAG	p.Q586K	LRRCC1_uc010lzz.1_RNA|LRRCC1_uc010maa.1_Missense_Mutation_p.Q287K|LRRCC1_uc003ycx.2_Missense_Mutation_p.Q493K|LRRCC1_uc003ycy.2_Missense_Mutation_p.Q566K	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	586	Potential.				cell division|mitosis	centriole|nucleus					0						ATTGAAAGAACAGGAACACAG	0.348													13	49					4.36969e-10	7.52813e-10	1	0	A	86042283	A	A	86042283	3	1	236	1	0	0	0	0	1	0	0	0	9076	479	17	4	1798	4	LRRCC1	8	86042283	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	18684747	86042283	60321739	267	42905											
CA3	761	broad.mit.edu	37	chr8	86351950	86351950	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatttcctaggtcctgaccActggcatgaacttttcccaa	9	14	6	12	0	0	2	0	2	0	0	3	2	3	2	4	2	1	1	4	2	4	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:86351950A>T	uc003ydj.2	+	2	127	c.44A>T	c.(43-45)CAC>CTC	p.H15L	CA13_uc003ydf.1_RNA|CA3_uc011lfv.1_RNA	NM_005181	NP_005172	P07451	CAH3_HUMAN	carbonic anhydrase III	15					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0						GGTCCTGACCACTGGCATGAA	0.473													9	25					0	0	0	0	T	86351950	T	T	86351950	3	4	236	1	0	0	0	0	1	0	0	0	2529	159	6	5	50	5	CA3	8	86351950	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	309667	86351950	60012072	268	42906											
ATP6V1C1	528	broad.mit.edu	37	chr8	104054596	104054596	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggatgtcttggttggctTgtcagatgaactggctaaac	8	14	13	6	0	2	2	1	1	1	1	2	3	2	3	0	4	2	4	0	4	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:104054596T>G	uc003ykz.3	+	3	406	c.161T>G	c.(160-162)TTG>TGG	p.L54W	ATP6V1C1_uc010mbz.2_5'UTR|ATP6V1C1_uc003yla.2_Missense_Mutation_p.L54W|ATP6V1C1_uc011lhl.1_Intron	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	54					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			TTGGTTGGCTTGTCAGATGAA	0.363													75	45					0	0	0	0	G	104054596	G	G	104054596	3	3	236	1	0	0	0	0	1	0	0	0	1182	1821	63	5	167	5	ATP6V1C1	8	104054596	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	17702646	104054596	42309426	269	42907											
PKHD1L1	93035	broad.mit.edu	37	chr8	110509197	110509197	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacaatgaagcccatggaggTttatatgggatctatatgaa	14	11	11	5	0	1	2	0	2	1	0	1	5	1	4	1	3	1	1	1	3	7	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:110509197T>A	uc003yne.2	+	64	10481	c.10377T>A	c.(10375-10377)GGT>GGA	p.G3459G		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3459	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCCATGGAGGTTTATATGGGA	0.388										HNSCC(38;0.096)			38	93					0	0	0	0	A	110509197	A	A	110509197	2	1	236	1	0	0	0	0	0	0	0	1	12027	1712	60	5		5	PKHD1L1	8	110509197	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	6454601	110509197	35854825	270	42908											
CSMD3	114788	broad.mit.edu	37	chr8	113694687	113694687	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttacctccacattttggaatCagtccactccacattacttt	10	15	3	13	0	1	0	1	0	0	0	4	1	4	1	4	1	2	0	4	1	3	5	rs147640061		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:113694687C>T	uc003ynu.2	-	16	2820	c.2661G>A	c.(2659-2661)CTG>CTA	p.L887L	CSMD3_uc003yns.2_Silent_p.L159L|CSMD3_uc003ynt.2_Silent_p.L847L|CSMD3_uc011lhx.1_Silent_p.L783L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	887	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATTTTGGAATCAGTCCACTCC	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			36	88					0	0	0	0	T	113694687	T	T	113694687	2	4	236	1	0	0	0	0	0	0	0	1	3963	813	29	2		2	CSMD3	8	113694687	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3185490	113694687	32669335	271	42909											
CSMD3	114788	broad.mit.edu	37	chr8	114111075	114111075	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atatgagtgaaattgtgtccCcaggctctgctacaatggtc	10	12	10	9	0	1	2	0	2	1	0	3	2	2	2	2	2	2	2	2	2	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:114111075C>T	uc003ynu.2	-	5	986	c.827G>A	c.(826-828)GGG>GAG	p.G276E	CSMD3_uc003ynt.2_Missense_Mutation_p.G236E|CSMD3_uc011lhx.1_Missense_Mutation_p.G276E|CSMD3_uc010mcx.1_Missense_Mutation_p.G276E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	276	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATTGTGTCCCCAGGCTCTGC	0.393										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	24					0	0	0	0	T	114111075	T	T	114111075	3	4	236	1	0	0	0	0	1	0	0	0	3963	623	22	4	10564	4	CSMD3	8	114111075	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	416388	114111075	32252947	272	42910											
COL14A1	7373	broad.mit.edu	37	chr8	121290348	121290348	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaatacaccttctctctccAggttgcaatggttcagttca	9	14	7	11	0	4	1	2	1	2	0	6	1	4	1	2	2	2	4	2	2	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:121290348A>T	uc003yox.2	+	27	3479	c.3214_splice	c.e27-2	p.V1072_splice	COL14A1_uc003yoz.2_Splice_Site_p.V37_splice	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor						cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TTCTCTCTCCAGGTTGCAATG	0.373													28	126					0	0	0	0	T	121290348	T	T	121290348	5	4	236	1	0	0	0	0	0	0	1	0	3686	202	7	5	3314	5	COL14A1	8	121290348	Splice_Site	SNP	A	TCGA-CV-7245-01A-11D-2012-08	7179273	121290348	25073674	273	42911											
MTBP	27085	broad.mit.edu	37	chr8	121475942	121475942	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttagtacagaggattgacaAacagtaccaaacagaattct	17	9	7	8	0	1	3	0	1	1	2	1	4	1	4	1	1	4	2	1	1	6	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:121475942A>G	uc003ypc.1	+	10	1033	c.988A>G	c.(988-990)AAC>GAC	p.N330D	MTBP_uc011lie.1_RNA	NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	330					cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AGGATTGACAAACAGTACCAA	0.353													25	132					0	0	0	0	G	121475942	G	G	121475942	3	3	236	1	0	0	0	0	1	0	0	0	9965	14	1	5	1026	5	MTBP	8	121475942	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	185594	121475942	24888080	274	42912											
MYC	4609	broad.mit.edu	37	chr8	128753114	128753114	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtccgtccaagcagaggaGcaaaagctcatttctgaaga	13	8	10	10	1	2	3	1	1	1	2	4	4	4	4	2	1	3	3	2	1	4	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:128753114G>A	uc003ysi.2	+	3	1800	c.1275G>A	c.(1273-1275)GAG>GAA	p.E425E		NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	410					branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		AAGCAGAGGAGCAAAAGCTCA	0.458		3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL								42	282					0	0	0	0	A	128753114	A	A	128753114	2	1	236	1	0	0	0	0	0	0	0	1	10069	962	34	4		4	MYC	8	128753114	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	7277172	128753114	17610908	275	42913											
TG	7038	broad.mit.edu	37	chr8	134107379	134107379	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggaggtcagttgccccaTgtcatccagccaagaagtgg	12	7	12	10	0	2	1	2	0	0	1	3	2	3	2	4	3	2	1	4	3	3	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:134107379T>C	uc003ytw.2	+	42	7372	c.7331T>C	c.(7330-7332)ATG>ACG	p.M2444T	TG_uc010mdw.2_Missense_Mutation_p.M1203T|TG_uc011ljb.1_Missense_Mutation_p.M813T|TG_uc011ljc.1_Missense_Mutation_p.M577T|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2444					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGTTGCCCCATGTCATCCAGC	0.587													124	110					0	0	0	0	C	134107379	C	C	134107379	3	2	236	1	0	0	0	0	1	0	0	0	15879	1464	51	5	7497	5	TG	8	134107379	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	5354265	134107379	12256643	276	42914											
COL22A1	169044	broad.mit.edu	37	chr8	139824102	139824102	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacccaatctgttcactgccTggggtgggaggccgctgggg	6	8	16	11	1	2	0	1	0	1	0	2	1	2	1	3	6	2	2	3	6	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:139824102T>A	uc003yvd.2	-	9	1836	c.1389A>T	c.(1387-1389)CCA>CCT	p.P463P		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	463	Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GTTCACTGCCTGGGGTGGGAG	0.602										HNSCC(7;0.00092)			8	30					0	0	0	0	A	139824102	A	A	139824102	2	1	236	1	0	0	0	0	0	0	0	1	3696	1567	55	5		5	COL22A1	8	139824102	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	5716723	139824102	6539920	277	42915											
GPR20	2843	broad.mit.edu	37	chr8	142367609	142367609	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagatgcaggtgaggaagaGgatggagcagtgcatgttga	12	7	18	4	0	0	4	0	2	0	2	0	7	0	7	0	4	3	5	0	4	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:142367609G>A	uc003ywf.2	-	2	504	c.415C>T	c.(415-417)CTC>TTC	p.L139F		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	139	Helical; Name=3; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			GTGAGGAAGAGGATGGAGCAG	0.687													13	58					0	0	0	0	A	142367609	A	A	142367609	3	1	236	1	0	0	0	0	1	0	0	0	6718	1000	35	4	665	4	GPR20	8	142367609	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2543507	142367609	3996413	278	42916											
PLEC	5339	broad.mit.edu	37	chr8	144996134	144996134	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctttgtggcagccacctGcgaggcagtgacctcctctg	5	10	13	13	1	2	1	0	1	2	0	3	2	3	1	4	3	2	2	4	3	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr8:144996134G>T	uc003zaf.1	-	32	8436	c.8266C>A	c.(8266-8268)CAG>AAG	p.Q2756K	PLEC_uc003zab.1_Missense_Mutation_p.Q2619K|PLEC_uc003zac.1_Missense_Mutation_p.Q2623K|PLEC_uc003zad.2_Missense_Mutation_p.Q2619K|PLEC_uc003zae.1_Missense_Mutation_p.Q2587K|PLEC_uc003zag.1_Missense_Mutation_p.Q2597K|PLEC_uc003zah.2_Missense_Mutation_p.Q2605K|PLEC_uc003zaj.2_Missense_Mutation_p.Q2646K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2756	Globular 2.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCAGCCACCTGCGAGGCAGTG	0.682													20	34					3.51602e-12	6.26629e-12	1	0	T	144996134	T	T	144996134	3	4	236	1	0	0	0	0	1	0	0	0	12107	1328	46	4	5792	4	PLEC	8	144996134	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2628525	144996134	1367888	279	42917											
BNC2	54796	broad.mit.edu	37	chr9	16437438	16437438	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaatggatttggtttctcCaaaccgcagaaactgctgaa	13	10	8	10	1	1	2	0	1	1	1	2	3	1	3	2	2	3	3	2	2	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:16437438C>T	uc003zml.2	-	6	894	c.754G>A	c.(754-756)GGA>AGA	p.G252R	BNC2_uc011lmw.1_Missense_Mutation_p.G157R|BNC2_uc003zmm.2_Missense_Mutation_p.G210R|BNC2_uc003zmq.1_Missense_Mutation_p.G266R|BNC2_uc003zmr.1_Missense_Mutation_p.G289R|BNC2_uc003zmp.1_Missense_Mutation_p.G280R|BNC2_uc010mij.1_Missense_Mutation_p.G174R|BNC2_uc011lmv.1_Missense_Mutation_p.G78R|BNC2_uc003zmo.1_Missense_Mutation_p.G174R|BNC2_uc003zmj.2_Missense_Mutation_p.G17R|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.G17R|BNC2_uc003zmn.1_Missense_Mutation_p.G17R	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		TTGGTTTCTCCAAACCGCAGA	0.502													23	65					0	0	0	0	T	16437438	T	T	16437438	3	4	236	1	0	0	0	0	1	0	0	0	1478	603	21	4	2553	4	BNC2	9	16437438	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08		16437438	124775993	280	42918											
CDKN2A	1029	broad.mit.edu	37	chr9	21974763	21974763	+	Frame_Shift_Del	DEL	G	-	-																															cacctcctctacccgaccccGggccgcggccgtggccagcc																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:21974763delG	uc003zpk.2	-	1	276	c.64delC	c.(64-66)CGGfs	p.R22fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Frame_Shift_Del_p.R22fs|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	22	ANK 1.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(23)|p.R22P(1)|p.R22fs*14(1)|p.S12fs*20(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		ACCCGACCCCGGGCCGCGGCC	0.736		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---								-	21974763	-	-	21974763	7	5	236	1	0	1	0	1	0	0	0	0	3176	1115	39	0	619	0	CDKN2A	9	21974763	Frame_Shift_Del	DEL	G	TCGA-CV-7245-01A-11D-2012-08	5537325	21974763	119238668	281	42919											
PLAA	9373	broad.mit.edu	37	chr9	26925866	26925866	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgtcgagcacacagcagcAccatatagactgagctggaa	14	7	10	10	1	0	2	0	1	0	1	1	4	0	3	1	1	4	4	1	1	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:26925866A>G	uc003zqd.2	-	6	1251	c.826T>C	c.(826-828)TGC>CGC	p.C276R	PLAA_uc003zqe.2_Missense_Mutation_p.C276R	NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	276	WD 7.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		ACACAGCAGCACCATATAGAC	0.418													21	13					0	0	0	0	G	26925866	G	G	26925866	3	3	236	1	0	0	0	0	1	0	0	0	12066	159	6	5	1597	5	PLAA	9	26925866	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	4951103	26925866	114287565	282	42920											
DDX58	23586	broad.mit.edu	37	chr9	32493895	32493895	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actcctccaacttttcaattTttttgaaatcccaactttca	11	17	1	12	0	2	1	2	1	0	0	5	1	5	1	3	0	2	0	3	0	4	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:32493895T>G	uc003zra.2	-	3	445	c.287A>C	c.(286-288)AAA>ACA	p.K96T	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Missense_Mutation_p.K51T|DDX58_uc011lnr.1_5'UTR|DDX58_uc010mji.2_Missense_Mutation_p.K25T	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	96	CARD 2.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		CTTTTCAATTTTTTTGAAATC	0.294													19	5					0	0	0	0	G	32493895	G	G	32493895	3	3	236	1	0	0	0	0	1	0	0	0	4392	1841	64	5	2554	5	DDX58	9	32493895	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	5568029	32493895	108719536	283	42921											
APBA1	320	broad.mit.edu	37	chr9	72073080	72073080	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtactgcaccttcttccTgcttttggctaatttctggg	4	19	8	10	0	2	0	0	0	2	0	3	0	3	0	2	2	3	4	2	2	2	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:72073080T>C	uc004ahh.2	-	6	1783	c.1507A>G	c.(1507-1509)AGG>GGG	p.R503G		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	503	PID.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						ACCTTCTTCCTGCTTTTGGCT	0.368													8	54					0	0	0	0	C	72073080	C	C	72073080	3	2	236	1	0	0	0	0	1	0	0	0	756	1579	55	5	1038	5	APBA1	9	72073080	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	39579185	72073080	69140351	284	42922											
DAPK1	1612	broad.mit.edu	37	chr9	90321930	90321930	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcggaggaaactgagtcGcctgctggacccgcccgacc	8	5	12	16	4	0	1	0	1	0	0	2	5	0	4	4	3	2	1	4	3	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:90321930G>A	uc004apc.2	+	26	4082	c.3944G>A	c.(3943-3945)CGC>CAC	p.R1315H	DAPK1_uc004apd.2_Missense_Mutation_p.R1315H|DAPK1_uc011ltg.1_Missense_Mutation_p.R1249H|DAPK1_uc011lth.1_Missense_Mutation_p.R1052H|DAPK1_uc004apg.2_Missense_Mutation_p.R292H	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	1315	Death.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						AAACTGAGTCGCCTGCTGGAC	0.597									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				44	66					0	0	0	0	A	90321930	A	A	90321930	3	1	236	1	0	0	0	0	1	0	0	0	4252	1087	38	1	4042	1	DAPK1	9	90321930	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	18248850	90321930	50891501	285	42923											
FAM75C1	441452	broad.mit.edu	37	chr9	90535519	90535519	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcctgctctccacctcctCcgaaaggcttcactcctcct	5	11	6	19	1	2	0	1	0	1	0	7	1	6	0	7	2	1	2	7	2	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:90535519C>A	uc010mqi.2	+	4	726	c.697C>A	c.(697-699)CCG>ACG	p.P233T	FAM75C1_uc004apq.3_Missense_Mutation_p.P216T	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						TCCACCTCCTCCGAAAGGCTT	0.587													149	231					8.49357e-55	1.80534e-54	1	0	A	90535519	A	A	90535519	3	1	236	1	0	0	0	0	1	0	0	0	5655	855	30	2	711	2	FAM75C1	9	90535519	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	213589	90535519	50677912	286	42924											
KIAA1529	57653	broad.mit.edu	37	chr9	100070394	100070394	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccgaatgggaaagcctacCagcagatcttccaggctgag	11	8	11	11	1	1	2	0	1	1	1	3	4	3	3	4	2	3	2	4	2	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:100070394C>T	uc011lut.1	+	14	1371	c.598C>T	c.(598-600)CAG>TAG	p.Q200*	KIAA1529_uc004axe.1_Nonsense_Mutation_p.Q200*|KIAA1529_uc004axg.1_Nonsense_Mutation_p.Q61*|KIAA1529_uc011lus.1_Nonsense_Mutation_p.Q61*|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Nonsense_Mutation_p.Q61*|KIAA1529_uc011luv.1_Nonsense_Mutation_p.Q61*	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				GAAAGCCTACCAGCAGATCTT	0.617													30	47					0	0	0	0	T	100070394	T	T	100070394	4	4	236	1	0	0	0	0	0	1	0	0	8279	595	21	4	616	4	KIAA1529	9	100070394	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	9534875	100070394	41143037	287	42925											
RNF20	56254	broad.mit.edu	37	chr9	104314536	104314536	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagagaagcccagtctgacCtgaacaaggtaaccagaggg	14	5	13	9	0	1	5	0	3	1	2	1	6	1	5	3	2	3	1	3	2	4	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:104314536C>G	uc004bbn.2	+	12	1612	c.1522C>G	c.(1522-1524)CTG>GTG	p.L508V		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	508	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		CCAGTCTGACCTGAACAAGGT	0.443													26	116					0	0	0	0	G	104314536	G	G	104314536	3	3	236	1	0	0	0	0	1	0	0	0	13538	680	24	4	1564	4	RNF20	9	104314536	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4244142	104314536	36898895	288	42926											
OR13C2	392376	broad.mit.edu	37	chr9	107367190	107367190	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagtcagatgggctgaacagGtagaggaagctttgcttctc	10	10	13	8	0	2	3	1	1	1	2	3	4	2	4	0	3	3	4	0	3	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:107367190G>C	uc011lvq.1	-	1	719	c.719C>G	c.(718-720)ACC>AGC	p.T240S		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGCTGAACAGGTAGAGGAAGC	0.403													21	90					0	0	0	0	C	107367190	C	C	107367190	3	2	236	1	0	0	0	0	1	0	0	0	10988	1261	44	4	240	4	OR13C2	9	107367190	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3052654	107367190	33846241	289	42927											
ZNF462	58499	broad.mit.edu	37	chr9	109687822	109687822	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgcagcagcaacagccaccGcagccaccaccaccgccgcc	10	2	8	21	3	0	0	0	0	0	0	0	0	0	0	8	0	6	4	8	0	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:109687822G>C	uc004bcz.2	+	3	1918	c.1629G>C	c.(1627-1629)CCG>CCC	p.P543P	ZNF462_uc010mto.2_Silent_p.P391P|ZNF462_uc004bda.2_Silent_p.P391P	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	543					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						AACAGccaccgcagccaccac	0.433													5	32					0	0	0	0	C	109687822	C	C	109687822	2	2	236	1	0	0	0	0	0	0	0	1	17993	1074	38	3		3	ZNF462	9	109687822	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2320632	109687822	31525609	290	42928											
ZNF462	58499	broad.mit.edu	37	chr9	109691031	109691031	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttttcccagtcgccccCgaagctgccagtccccctcg	4	10	8	19	3	1	0	0	0	1	0	5	1	3	0	6	0	2	1	6	0	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:109691031C>T	uc004bcz.2	+	3	5127	c.4838C>T	c.(4837-4839)CCG>CTG	p.P1613L	ZNF462_uc010mto.2_Missense_Mutation_p.P1461L|ZNF462_uc004bda.2_Missense_Mutation_p.P1461L	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1613					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CAGTCGCCCCCGAAGCTGCCA	0.537													24	123					0	0	0	0	T	109691031	T	T	109691031	3	4	236	1	0	0	0	0	1	0	0	0	17993	652	23	1	4844	1	ZNF462	9	109691031	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3209	109691031	31522400	291	42929											
CTNNAL1	8727	broad.mit.edu	37	chr9	111735078	111735078	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatcagcatggtattttaaTagatctgctgccagctgtgt	9	15	10	7	0	2	2	1	1	1	1	2	2	2	2	1	1	4	4	1	1	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:111735078T>C	uc004bdo.1	-	9	1266	c.1224A>G	c.(1222-1224)CTA>CTG	p.L408L	CTNNAL1_uc010mts.1_Intron|CTNNAL1_uc010mtt.1_Silent_p.L408L|CTNNAL1_uc004bdp.1_Silent_p.L408L|CTNNAL1_uc004bdq.1_5'UTR	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	408					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		GGTATTTTAATAGATCTGCTG	0.453													27	69					0	0	0	0	C	111735078	C	C	111735078	2	2	236	1	0	0	0	0	0	0	0	1	4032	1393	49	5		5	CTNNAL1	9	111735078	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2044047	111735078	29478353	292	42930											
AKAP2	11217	broad.mit.edu	37	chr9	112811016	112811033	+	In_Frame_Del	DEL	CCCCCGGAGTCTCCTGGA	-	-																															ccggggctgccgctcgccttCccccggagtctcctggaccc																								rs72207945		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	bdc58b10-1756-45bf-a34f-fa4095429476	g.chr9:112811016_112811033delCCCCCGGAGTCTCCTGGA	uc011lwi.1	+	1	41_58	c.37_54delCCCCCGGAGTCTCCTGGA	c.(37-54)CCCCCGGAGTCTCCTGGAdel	p.PPESPG19del	PALM2-AKAP2_uc004bei.2_Intron|PALM2-AKAP2_uc004bek.3_Intron|PALM2-AKAP2_uc004bej.3_Intron|PALM2-AKAP2_uc004bel.1_Intron|AKAP2_uc004bem.2_In_Frame_Del_p.PPESPG19del	NM_001004065	NP_001004065	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 1	373_378							enzyme binding			ovary(2)	2						CGCTCGCCTTCCCCCGGAGTCTCCTGGACCCCCGGAGT	0.789													---	---	---								-	112811033	-	-	112811016	7	5	236	1	0	1	0	1	0	0	0	0	451	855	30	0	39	0	AKAP2	9	112811016	In_Frame_Del	DEL	CCCCCGGAGTCTCCTGGA	TCGA-CV-7245-01A-11D-2012-08	1075938	112811016	28402415	293	42931											
ZNF883	169834	broad.mit.edu	37	chr9	115760475	115760475	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcagggatgcaagacaagtgTagcctttcccacattcagta	12	10	9	10	0	2	1	2	0	0	1	3	2	3	2	2	1	2	3	2	1	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:115760475T>C	uc011lwy.1	-	5	1304	c.65A>G	c.(64-66)TAC>TGC	p.Y22C		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	22	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGACAAGTGTAGCCTTTCCC	0.368													42	67					0	0	0	0	C	115760475	C	C	115760475	3	2	236	1	0	0	0	0	1	0	0	0	18265	1638	57	5	1076	5	ZNF883	9	115760475	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2949459	115760475	25452956	294	42932											
TLR4	7099	broad.mit.edu	37	chr9	120476305	120476305	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtcagatgaataagaccatCattggtgtgtcggtcctcag	10	12	11	8	1	3	3	3	1	0	2	5	3	4	3	2	2	0	0	2	2	2	2	rs140661916		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:120476305C>T	uc004bjz.2	+	3	2190	c.1899C>T	c.(1897-1899)ATC>ATT	p.I633I	TLR4_uc004bka.2_Silent_p.I593I|TLR4_uc004bkb.2_Silent_p.I433I	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	633	Helical; (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ATAAGACCATCATTGGTGTGT	0.438													6	35					0	0	0	0	T	120476305	T	T	120476305	2	4	236	1	0	0	0	0	0	0	0	1	16019	816	29	2		2	TLR4	9	120476305	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4715830	120476305	20737126	295	42933											
VAV2	7410	broad.mit.edu	37	chr9	136635537	136635537	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccctggaggccgaacgttcCcgggacttgtaggggtactt	6	9	15	11	3	0	0	0	0	0	0	1	3	1	2	3	5	2	3	3	5	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:136635537C>A	uc004ces.2	-	27	2356	c.2310G>T	c.(2308-2310)CGG>CGT	p.R770R	VAV2_uc004cer.2_Silent_p.R760R|VAV2_uc004cet.1_Silent_p.R309R	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	770					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CCGAACGTTCCCGGGACTTGT	0.647													12	74					1.08611e-07	1.7776e-07	1	0	A	136635537	A	A	136635537	2	1	236	1	0	0	0	0	0	0	0	1	17200	610	22	4		4	VAV2	9	136635537	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	16159232	136635537	4577894	296	42934											
SNAPC4	6621	broad.mit.edu	37	chr9	139290116	139290116	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcttctcctggatgaccTcctggtagaccatgttcagc	7	11	9	14	0	2	2	1	1	1	1	4	3	3	3	5	2	2	3	5	2	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:139290116T>A	uc004chh.2	-	3	293	c.284A>T	c.(283-285)GAG>GTG	p.E95V		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	95	SNAPC5-binding.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CTGGATGACCTCCTGGTAGAC	0.632													88	152					0	0	0	0	A	139290116	A	A	139290116	3	1	236	1	0	0	0	0	1	0	0	0	14901	1551	54	5	4205	5	SNAPC4	9	139290116	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2654579	139290116	1923315	297	42935											
ENTPD8	377841	broad.mit.edu	37	chr9	140329398	140329407	+	Frame_Shift_Del	DEL	CAGCCCCCAC	-	-																															ccagaagagctggaccaaggCagcccccaccaccgccacca																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:140329398_140329407delCAGCCCCCAC	uc004cmw.2	-	10	1631_1640	c.1447_1456delGTGGGGGCTG	c.(1447-1458)GTGGGGGCTGCCfs	p.V483fs	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Frame_Shift_Del_p.V446fs	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	483_486	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		TGGACCAAGGCAGCCCCCACCACCGCCACC	0.681													---	---	---								-	140329407	-	-	140329398	7	5	236	1	0	1	0	1	0	0	0	0	5169	710	25	0	35	0	ENTPD8	9	140329398	Frame_Shift_Del	DEL	CAGCCCCCAC	TCGA-CV-7245-01A-11D-2012-08	1039282	140329398	884033	298	42936											
PNPLA7	375775	broad.mit.edu	37	chr9	140357226	140357226	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggtgaggtccgtctcatCtcggctgcccacgtcaatgg	5	11	13	12	3	3	1	2	1	2	0	6	1	4	1	2	4	1	2	2	4	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr9:140357226C>A	uc004cnf.2	-	29	3665	c.3328G>T	c.(3328-3330)GAT>TAT	p.D1110Y	C9orf167_uc011mew.1_Intron|PNPLA7_uc004cnd.1_Missense_Mutation_p.D376Y|PNPLA7_uc004cne.1_Missense_Mutation_p.D376Y|PNPLA7_uc011mfa.1_Missense_Mutation_p.D518Y|PNPLA7_uc010ncj.1_Missense_Mutation_p.D1135Y	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1110					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TCCGTCTCATCTCGGCTGCCC	0.617													29	60					2.68265e-12	4.80021e-12	1	0	A	140357226	A	A	140357226	3	1	236	1	0	0	0	0	1	0	0	0	12225	913	32	2	649	2	PNPLA7	9	140357226	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	27828	140357226	856205	299	42937											
SFMBT2	57713	broad.mit.edu	37	chr10	7409710	7409710	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaagtcggccctgcggtcctCcccgtaaccgcagtagcgca	7	6	12	16	5	0	0	0	0	0	0	3	1	2	0	5	2	3	4	5	2	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:7409710C>T	uc009xio.1	-	4	428	c.337G>A	c.(337-339)GAG>AAG	p.E113K	SFMBT2_uc001ijn.1_Missense_Mutation_p.E113K|SFMBT2_uc010qay.1_Missense_Mutation_p.E113K|SFMBT2_uc001ijo.1_Missense_Mutation_p.E113K	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	113	MBT 1.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						CTGCGGTCCTCCCCGTAACCG	0.597													11	26					0	0	0	0	T	7409710	T	T	7409710	3	4	236	1	0	0	0	0	1	0	0	0	14223	864	30	2	2419	2	SFMBT2	10	7409710	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08		7409710	128125037	300	42938											
SFMBT2	57713	broad.mit.edu	37	chr10	7409747	7409747	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcagaagcagcagctgcccGcacgtggtaatgatcgtggc	9	6	14	12	4	0	2	0	1	0	1	1	2	0	2	1	2	4	6	1	2	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:7409747G>C	uc009xio.1	-	4	391	c.300C>G	c.(298-300)TGC>TGG	p.C100W	SFMBT2_uc001ijn.1_Missense_Mutation_p.C100W|SFMBT2_uc010qay.1_Missense_Mutation_p.C100W|SFMBT2_uc001ijo.1_Missense_Mutation_p.C100W	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	100	MBT 1.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						GCAGCTGCCCGCACGTGGTAA	0.567													6	26					0	0	0	0	C	7409747	C	C	7409747	3	2	236	1	0	0	0	0	1	0	0	0	14223	1079	38	3	2456	3	SFMBT2	10	7409747	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	37	7409747	128125000	301	42939											
ZNF33B	7582	broad.mit.edu	37	chr10	43089499	43089499	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactttcaccacaatcatagTgtttcacaggtaccccatca	12	11	4	14	0	4	0	4	0	0	0	4	0	4	0	3	1	1	2	3	1	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:43089499T>C	uc001jaf.1	-	5	1014	c.899A>G	c.(898-900)CAC>CGC	p.H300R	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.H188R|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	300						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACAATCATAGTGTTTCACAGG	0.383													23	57					0	0	0	0	C	43089499	C	C	43089499	3	2	236	1	0	0	0	0	1	0	0	0	17922	1696	59	5	1441	5	ZNF33B	10	43089499	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	35679752	43089499	92445248	302	42940											
ANUBL1	93550	broad.mit.edu	37	chr10	46121668	46121668	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aataacatcagatcttttccCaagtgaatcaactttaacac	16	12	3	10	0	3	2	2	1	1	1	4	2	4	2	1	0	3	0	1	0	6	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:46121668C>A	uc001jcp.3	-	7	1845	c.1603G>T	c.(1603-1605)GGG>TGG	p.G535W	ANUBL1_uc001jcl.3_Missense_Mutation_p.G55W|ANUBL1_uc001jcm.3_Missense_Mutation_p.G535W|ANUBL1_uc009xmu.2_Missense_Mutation_p.G461W|ANUBL1_uc001jcn.3_Missense_Mutation_p.G461W|ANUBL1_uc001jco.3_Intron	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	535							zinc ion binding				0						GATCTTTTCCCAAGTGAATCA	0.388													20	72					8.34094e-07	1.33837e-06	1	0	A	46121668	A	A	46121668	3	1	236	1	0	0	0	0	1	0	0	0	713	594	21	4	596	4	ANUBL1	10	46121668	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3032169	46121668	89413079	303	42941											
PPYR1	5540	broad.mit.edu	37	chr10	47087815	47087815	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgacttgccagcagagcgcCcccctggaggagtcggagca	8	5	14	14	2	0	2	0	1	0	1	1	5	0	5	4	3	4	2	4	3	0	1	rs142467576		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:47087815C>G	uc001jee.2	+	3	1451	c.1032C>G	c.(1030-1032)GCC>GCG	p.A344A	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.A344A	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	344	Cytoplasmic (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						AGCAGAGCGCCCCCCTGGAGG	0.562													17	82					0	0	0	0	G	47087815	G	G	47087815	2	3	236	1	0	0	0	0	0	0	0	1	12476	610	22	4		4	PPYR1	10	47087815	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	966147	47087815	88446932	304	42942											
PCDH15	65217	broad.mit.edu	37	chr10	55568470	55568470	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttcaaagtgctgtgttgtaAccttcagagtttgctcctgg	7	16	10	8	0	2	1	2	0	0	1	3	1	3	1	2	1	3	5	2	1	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:55568470A>T	uc010qhs.1	-	37	5750	c.5355T>A	c.(5353-5355)GGT>GGA	p.G1785G	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Silent_p.G1778G|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTGTGTTGTAACCTTCAGAGT	0.483										HNSCC(58;0.16)			6	19					0	0	0	0	T	55568470	T	T	55568470	2	4	236	1	0	0	0	0	0	0	0	1	11565	30	2	5		5	PCDH15	10	55568470	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	8480655	55568470	79966277	305	42943											
ANK3	288	broad.mit.edu	37	chr10	61830610	61830610	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaagctttgggtttttctttTtgttcatcgtccacttcctt	4	21	7	9	1	2	0	1	0	1	0	5	1	4	0	2	1	1	3	2	1	1	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:61830610T>C	uc001jky.2	-	37	10221	c.10029A>G	c.(10027-10029)CAA>CAG	p.Q3343Q	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3343					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTTTTTCTTTTTGTTCATCGT	0.403													43	85					0	0	0	0	C	61830610	C	C	61830610	2	2	236	1	0	0	0	0	0	0	0	1	622	1838	64	5		5	ANK3	10	61830610	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	6262140	61830610	73704137	306	42944											
ARID5B	84159	broad.mit.edu	37	chr10	63851213	63851213	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caaagacaaagacctgactgGgcccatgaacgagaaccatg	16	4	10	11	1	0	5	0	2	0	3	0	6	0	5	3	1	2	0	3	1	4	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:63851213G>T	uc001jlt.1	+	10	2017	c.1991G>T	c.(1990-1992)GGG>GTG	p.G664V		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	664					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GACCTGACTGGGCCCATGAAC	0.532													8	31					0.00307968	0.00452731	1	0	T	63851213	T	T	63851213	3	4	236	1	0	0	0	0	1	0	0	0	922	1232	43	4	2029	4	ARID5B	10	63851213	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2020603	63851213	71683534	307	42945											
JMJD1C	221037	broad.mit.edu	37	chr10	64960389	64960389	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggattccccagtttgcttcAgcttcttgactttacgccaa	8	14	7	12	1	2	1	1	1	1	0	3	2	3	2	3	1	3	3	3	1	2	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:64960389A>C	uc001jmn.2	-	11	5423	c.5123T>G	c.(5122-5124)CTG>CGG	p.L1708R	JMJD1C_uc001jml.2_Missense_Mutation_p.L1489R|JMJD1C_uc001jmm.2_Missense_Mutation_p.L1420R|JMJD1C_uc010qiq.1_Missense_Mutation_p.L1526R|JMJD1C_uc009xpi.2_Missense_Mutation_p.L1526R|JMJD1C_uc009xpj.1_Intron|JMJD1C_uc009xpk.1_Intron	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1708					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGTTTGCTTCAGCTTCTTGAC	0.373													3	16					0	0	0	0	C	64960389	C	C	64960389	3	2	236	1	0	0	0	0	1	0	0	0	7989	188	7	5	2563	5	JMJD1C	10	64960389	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	1109176	64960389	70574358	308	42946											
LRRTM3	347731	broad.mit.edu	37	chr10	68687888	68687888	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggtgggagccacagagcccgGcccagagaccgatgctgacg	9	3	16	13	3	0	3	0	1	0	2	0	6	0	4	4	3	3	1	4	3	0	0	rs150432500		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:68687888G>T	uc001jmz.1	+	2	1764	c.1214G>T	c.(1213-1215)GGC>GTC	p.G405V	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.G405V	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	405	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						ACAGAGCCCGGCCCAGAGACC	0.617													23	56					3.5997e-14	6.65707e-14	1	0	T	68687888	T	T	68687888	3	4	236	1	0	0	0	0	1	0	0	0	9091	1203	42	4	1220	4	LRRTM3	10	68687888	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3727499	68687888	66846859	309	42947											
DNAJC12	56521	broad.mit.edu	37	chr10	69571401	69571401	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagaatctcctttgccttctGcagtttctgaaaagtctcca	9	14	6	12	0	4	2	0	1	4	1	6	2	4	2	3	0	2	2	3	0	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:69571401G>A	uc001jnb.2	-	3	346	c.178C>T	c.(178-180)CAG>TAG	p.Q60*	DNAJC12_uc001jnc.2_Nonsense_Mutation_p.Q60*	NM_021800	NP_068572	Q9UKB3	DJC12_HUMAN	J domain containing protein 1 isoform a	60	J.				protein folding		heat shock protein binding|unfolded protein binding			breast(1)	1						TTTGCCTTCTGCAGTTTCTGA	0.458													23	69					0	0	0	0	A	69571401	A	A	69571401	4	1	236	1	0	0	0	0	0	1	0	0	4653	1328	46	4	457	4	DNAJC12	10	69571401	Nonsense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	883513	69571401	65963346	310	42948											
ZMIZ1	57178	broad.mit.edu	37	chr10	81050778	81050778	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcggcaaccccatggcGtcgggcatgaccaccagcaa	10	3	12	16	3	0	1	0	1	0	0	1	1	0	1	5	4	2	3	5	4	2	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:81050778G>C	uc001kaf.2	+	10	1175	c.603G>C	c.(601-603)GCG>GCC	p.A201A	ZMIZ1_uc001kag.2_Silent_p.A77A|ZMIZ1_uc001kah.1_Silent_p.A77A	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	201					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			ACCCCATGGCGTCGGGCATGA	0.617													12	110					0	0	0	0	C	81050778	C	C	81050778	2	2	236	1	0	0	0	0	0	0	0	1	17763	1132	40	3		3	ZMIZ1	10	81050778	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	11479377	81050778	54483969	311	42949											
ANXA11	311	broad.mit.edu	37	chr10	81928966	81928966	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtttcctcctgggggtGgatacatcccatagggagga	7	10	16	8	0	0	0	0	0	0	0	3	3	3	3	3	6	1	1	3	6	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:81928966G>C	uc001kbq.1	-	6	1145	c.320C>G	c.(319-321)CCA>CGA	p.P107R	ANXA11_uc010qlx.1_Missense_Mutation_p.P207R|ANXA11_uc001kbr.1_Missense_Mutation_p.P107R|ANXA11_uc001kbs.1_Missense_Mutation_p.P107R|ANXA11_uc001kbt.1_Missense_Mutation_p.P107R|ANXA11_uc010qly.1_Missense_Mutation_p.P74R|ANXA11_uc009xsq.1_Missense_Mutation_p.P107R|ANXA11_uc001kbu.1_Missense_Mutation_p.P107R	NM_145869	NP_665876	P50995	ANX11_HUMAN	annexin A11	107					cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding			ovary(1)	1	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			TCCTGGGGGTGGATACATCCC	0.701													15	20					0	0	0	0	C	81928966	C	C	81928966	3	2	236	1	0	0	0	0	1	0	0	0	716	1348	47	4	1245	4	ANXA11	10	81928966	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	878188	81928966	53605781	312	42950											
NRG3	10718	broad.mit.edu	37	chr10	84498357	84498357	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaagaaggctaccaaggagtCcgttgtgatcaatttctgcc	12	10	10	9	1	2	2	1	1	1	1	3	3	3	3	3	2	2	2	3	2	5	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:84498357C>A	uc001kco.2	+	3	1005	c.978C>A	c.(976-978)GTC>GTA	p.V326V	NRG3_uc010qlz.1_Silent_p.V326V|NRG3_uc001kcp.2_Silent_p.V105V|NRG3_uc001kcq.2_5'UTR	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	326	EGF-like.|Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		ACCAAGGAGTCCGTTGTGATC	0.388													11	36					0.00010058	0.000152658	1	0	A	84498357	A	A	84498357	2	1	236	1	0	0	0	0	0	0	0	1	10703	842	30	2		2	NRG3	10	84498357	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2569391	84498357	51036390	313	42951											
LRIT1	26103	broad.mit.edu	37	chr10	85992290	85992290	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcctctgagggtcctgccCgcccatcagagagctctccc	5	8	11	17	1	3	2	1	1	2	1	5	3	4	2	5	1	3	1	5	1	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:85992290C>T	uc001kcz.1	-	4	1287	c.1265G>A	c.(1264-1266)CGG>CAG	p.R422Q		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	422	Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						GGGTCCTGCCCGCCCATCAGA	0.617													20	64					0	0	0	0	T	85992290	T	T	85992290	3	4	236	1	0	0	0	0	1	0	0	0	8997	652	23	1	610	1	LRIT1	10	85992290	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1493933	85992290	49542457	314	42952											
KIF20B	9585	broad.mit.edu	37	chr10	91497825	91497825	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctcttccaaaaaaagtcAtcagattgaggaactggaac	15	8	9	9	0	3	2	2	1	1	1	4	4	4	4	2	3	2	0	2	3	5	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:91497825A>C	uc001kgs.1	+	20	3299	c.3227A>C	c.(3226-3228)CAT>CCT	p.H1076P	KIF20B_uc001kgr.1_Missense_Mutation_p.H1036P|KIF20B_uc001kgt.1_Missense_Mutation_p.H287P|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1076					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						AAAAAAAGTCATCAGATTGAG	0.358													19	45					0	0	0	0	C	91497825	C	C	91497825	3	2	236	1	0	0	0	0	1	0	0	0	8326	217	8	5	3181	5	KIF20B	10	91497825	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	5505535	91497825	44036922	315	42953											
SLIT1	6585	broad.mit.edu	37	chr10	98803255	98803255	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgtggatgcagctgatgcgGttgttccgcagcattctggg	5	13	15	8	2	1	1	0	1	1	0	2	2	2	2	1	3	4	6	1	3	0	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:98803255G>T	uc001kmw.2	-	19	2121	c.1869C>A	c.(1867-1869)AAC>AAA	p.N623K	SLIT1_uc009xvh.1_Missense_Mutation_p.N633K	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	623	LRR 15.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		AGCTGATGCGGTTGTTCCGCA	0.652													13	21					9.05144e-12	1.59865e-11	1	0	T	98803255	T	T	98803255	3	4	236	1	0	0	0	0	1	0	0	0	14803	1252	44	4	2811	4	SLIT1	10	98803255	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	7305430	98803255	36731492	316	42954											
C10orf2	56652	broad.mit.edu	37	chr10	102749399	102749399	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctgttccaccccactgcAgggccaacaggcagtggaaa	10	6	12	13	0	1	0	0	0	1	0	2	1	2	1	4	4	2	3	4	4	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:102749399A>T	uc001ksf.2	+	2	1919	c.1244_splice	c.e2-2	p.G415_splice	MRPL43_uc001kry.1_5'Flank|MRPL43_uc010qpu.1_5'Flank|MRPL43_uc001krz.1_5'Flank|MRPL43_uc001ksa.1_5'Flank|MRPL43_uc001ksb.1_5'Flank|MRPL43_uc001ksd.1_5'Flank|MRPL43_uc001ksc.2_5'Flank|MRPL43_uc001kse.2_5'Flank|C10orf2_uc001ksg.2_Splice_Site_p.G415_splice|C10orf2_uc001ksi.2_Splice_Site|C10orf2_uc010qpv.1_Splice_Site|C10orf2_uc001ksh.2_Splice_Site	NM_021830	NP_068602	Q96RR1	PEO1_HUMAN	twinkle isoform A						cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			ovary(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		ACCCCACTGCAGGGCCAACAG	0.537													18	62					0	0	0	0	T	102749399	T	T	102749399	5	4	236	1	0	0	0	0	0	0	1	0	1603	202	7	5	1248	5	C10orf2	10	102749399	Splice_Site	SNP	A	TCGA-CV-7245-01A-11D-2012-08	3946144	102749399	32785348	317	42955											
LZTS2	84445	broad.mit.edu	37	chr10	102763890	102763890	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcttcagcagctgcgggaCagtctggacgagaatgaggc	10	6	16	9	2	2	2	1	1	1	1	2	6	2	4	0	3	4	3	0	3	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:102763890C>A	uc001ksj.2	+	3	1104	c.1035C>A	c.(1033-1035)GAC>GAA	p.D345E	LZTS2_uc010qpw.1_Missense_Mutation_p.D345E|LZTS2_uc001ksk.2_Missense_Mutation_p.D345E|LZTS2_uc001ksl.2_Missense_Mutation_p.D345E|LZTS2_uc001ksm.2_RNA	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	345	Potential.				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				ovary(2)|large_intestine(1)|breast(1)	4				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		AGCTGCGGGACAGTCTGGACG	0.632													11	40					6.40141e-05	9.77634e-05	1	0	A	102763890	A	A	102763890	3	1	236	1	0	0	0	0	1	0	0	0	9190	477	17	4	1041	4	LZTS2	10	102763890	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	14491	102763890	32770857	318	42956											
SLK	9748	broad.mit.edu	37	chr10	105762811	105762811	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagcaataaacagttcagaGaacataatggacatcaatga	20	7	7	7	0	2	2	2	1	0	1	2	4	2	3	0	1	3	2	0	1	7	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:105762811G>T	uc001kxo.1	+	9	1909	c.1875G>T	c.(1873-1875)GAG>GAT	p.E625D	SLK_uc001kxp.1_Missense_Mutation_p.E625D	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	625	Glu-rich.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		ACAGTTCAGAGAACATAATGG	0.388													10	24					3.86212e-05	5.90748e-05	1	0	T	105762811	T	T	105762811	3	4	236	1	0	0	0	0	1	0	0	0	14812	933	33	2	1909	2	SLK	10	105762811	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2998921	105762811	29771936	319	42957											
ATRNL1	26033	broad.mit.edu	37	chr10	116930892	116930892	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acatagtcagtcatggagtaCaaaaactcctactgttcttg	13	12	7	9	0	3	0	2	0	1	0	4	1	4	1	1	1	3	2	1	1	5	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:116930892C>G	uc001lcg.2	+	8	1576	c.1190C>G	c.(1189-1191)ACA>AGA	p.T397R	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Missense_Mutation_p.T397R|ATRNL1_uc009xyq.2_Missense_Mutation_p.Q368E	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	397	Kelch 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TCATGGAGTACAAAAACTCCT	0.383													42	41					0	0	0	0	G	116930892	G	G	116930892	3	3	236	1	0	0	0	0	1	0	0	0	1209	478	17	4	1220	4	ATRNL1	10	116930892	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	11168081	116930892	18603855	320	42958											
ADAM12	8038	broad.mit.edu	37	chr10	127738229	127738229	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaagcagatcccaggggcaGgtttagcacctgaaacagaa	15	5	11	10	0	0	3	0	1	0	2	1	3	1	3	2	3	3	4	2	3	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:127738229G>C	uc001ljk.2	-	15	2041	c.1628C>G	c.(1627-1629)CCT>CGT	p.P543R	ADAM12_uc010qul.1_Missense_Mutation_p.P494R|ADAM12_uc001ljm.2_Missense_Mutation_p.P543R|ADAM12_uc001ljn.2_Missense_Mutation_p.P540R|ADAM12_uc001ljl.3_Missense_Mutation_p.P540R	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	543	Extracellular (Potential).|Cys-rich.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CCCAGGGGCAGGTTTAGCACC	0.473													32	36					0	0	0	0	C	127738229	C	C	127738229	3	2	236	1	0	0	0	0	1	0	0	0	236	1000	35	4	1245	4	ADAM12	10	127738229	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	10807337	127738229	7796518	321	42959											
EBF3	253738	broad.mit.edu	37	chr10	131639253	131639253	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggggagtactgctggggacGtagcctcgcggggacacgct	6	7	18	10	4	0	0	0	0	0	0	1	3	0	3	1	6	3	4	1	6	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:131639253G>T	uc001lki.1	-	14	1448	c.1389C>A	c.(1387-1389)TAC>TAA	p.Y463*		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	472	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		TGCTGGGGACGTAGCCTCGCG	0.547													41	80					2.40579e-17	4.65057e-17	1	0	T	131639253	T	T	131639253	4	4	236	1	0	0	0	0	0	1	0	0	4904	1140	40	3	278	3	EBF3	10	131639253	Nonsense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3901024	131639253	3895494	322	42960											
CYP2E1	1571	broad.mit.edu	37	chr10	135350720	135350720	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgccccatgaagcaacccGagacaccattttcagaggat	12	7	8	14	1	1	3	1	1	0	2	1	5	1	4	5	1	3	1	5	1	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr10:135350720G>T	uc001lnj.1	+	7	1154	c.1121G>T	c.(1120-1122)CGA>CTA	p.R374L	CYP2E1_uc001lnk.1_Missense_Mutation_p.R237L|CYP2E1_uc009ybl.1_Missense_Mutation_p.R175L|CYP2E1_uc009ybm.1_Missense_Mutation_p.R28L|CYP2E1_uc001lnl.1_Missense_Mutation_p.R175L	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	374					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	GAAGCAACCCGAGACACCATT	0.527									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				14	67					6.72482e-11	1.17925e-10	1	0	T	135350720	T	T	135350720	3	4	236	1	0	0	0	0	1	0	0	0	4187	1058	37	3	1147	3	CYP2E1	10	135350720	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3711467	135350720	184027	323	42961											
ART1	417	broad.mit.edu	37	chr11	3681167	3681167	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccgtgcgtgaggcgggcCgctcccgggcccactacctc	4	5	14	18	5	0	1	0	1	0	0	2	1	1	1	5	3	3	1	5	3	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:3681167C>T	uc001lye.1	+	3	519	c.418C>T	c.(418-420)CGC>TGC	p.R140C	ART1_uc009yeb.1_Missense_Mutation_p.R140C	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	140					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	TGAGGCGGGCCGCTCCCGGGC	0.667													13	33					0	0	0	0	T	3681167	T	T	3681167	3	4	236	1	0	0	0	0	1	0	0	0	999	652	23	1	424	1	ART1	11	3681167	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08		3681167	131325349	324	42962											
OR52A1	23538	broad.mit.edu	37	chr11	5172865	5172865	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaagacacagatgtgagcAatgcaggtattgaatgcttt	14	10	12	5	0	0	4	0	2	0	2	0	5	0	5	0	2	3	4	0	2	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:5172865A>G	uc010qyy.1	-	1	735	c.735T>C	c.(733-735)ATT>ATC	p.I245I		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGATGTGAGCAATGCAGGTAT	0.428													13	43					0	0	0	0	G	5172865	G	G	5172865	2	3	236	1	0	0	0	0	0	0	0	1	11162	126	5	5		5	OR52A1	11	5172865	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	1491698	5172865	129833651	325	42963											
OR51B5	282763	broad.mit.edu	37	chr11	5364185	5364185	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtacagtcggttgaaggtGgtatcagcacaggcgagttt	9	10	16	6	2	1	1	1	1	0	0	2	2	1	1	0	5	2	5	0	5	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:5364185G>T	uc001map.1	-	1	570	c.570C>A	c.(568-570)ACC>ACA	p.T190T	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Silent_p.T190T	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGTTGAAGGTGGTATCAGCAC	0.428													48	71					2.59344e-38	5.4302e-38	1	0	T	5364185	T	T	5364185	2	4	236	1	0	0	0	0	0	0	0	1	11145	1335	47	4		4	OR51B5	11	5364185	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	191320	5364185	129642331	326	42964											
OR56A4	120793	broad.mit.edu	37	chr11	6023944	6023944	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggctgggaagctgatcgaCctgaggtcaaaccagaagat	13	6	13	9	1	1	4	1	2	0	2	2	6	1	5	2	3	2	2	2	3	3	0	rs144089765		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:6023944C>A	uc010qzv.1	-	1	435	c.435G>T	c.(433-435)AGG>AGT	p.R145S		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCTGATCGACCTGAGGTCAA	0.547													27	61					2.79863e-10	4.84701e-10	1	0	A	6023944	A	A	6023944	3	1	236	1	0	0	0	0	1	0	0	0	11189	506	18	4	664	4	OR56A4	11	6023944	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	659759	6023944	128982572	327	42965											
IPO7	10527	broad.mit.edu	37	chr11	9466672	9466672	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgattgagaagcatggaggAtacaaattcagtgctccagt	14	10	11	6	0	1	2	1	2	0	1	2	5	2	4	1	2	3	2	1	2	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:9466672A>C	uc001mho.2	+	25	3190	c.3048A>C	c.(3046-3048)GGA>GGC	p.G1016G		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	1016					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		AGCATGGAGGATACAAATTCA	0.378													15	46					0	0	0	0	C	9466672	C	C	9466672	2	2	236	1	0	0	0	0	0	0	0	1	7836	320	12	5		5	IPO7	11	9466672	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	3442728	9466672	125539844	328	42966											
MRGPRX2	117194	broad.mit.edu	37	chr11	19077157	19077157	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttaagagatgacaggacaaCtgaaactggatgaatatgac	17	8	11	5	0	0	5	0	4	0	1	0	8	0	7	0	2	2	1	0	2	5	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:19077157C>A	uc001mph.2	-	2	881	c.793G>T	c.(793-795)GTT>TTT	p.V265F		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	265	Helical; Name=7; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						GACAGGACAACTGAAACTGGA	0.478													26	37					7.33532e-06	1.14885e-05	1	0	A	19077157	A	A	19077157	3	1	236	1	0	0	0	0	1	0	0	0	9820	565	20	4	203	4	MRGPRX2	11	19077157	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	9610485	19077157	115929359	329	42967											
PAX6	5080	broad.mit.edu	37	chr11	31823216	31823216	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atactgggctattttgcttaCaacttctggagtcgctactc	8	15	8	10	1	1	0	0	0	1	0	3	1	1	1	0	2	5	3	0	2	5	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:31823216C>A	uc001mtd.3	-	5	1140	c.250G>T	c.(250-252)GTA>TTA	p.V84L	PAX6_uc001mte.3_Missense_Mutation_p.V84L|PAX6_uc001mtg.3_Missense_Mutation_p.V98L|PAX6_uc001mtf.3_Missense_Mutation_p.V84L|PAX6_uc001mth.3_Missense_Mutation_p.V84L|PAX6_uc009yjr.2_Missense_Mutation_p.V84L	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	84	Paired.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					ATTTTGCTTACAACTTCTGGA	0.502									Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				23	59					1.87028e-06	2.96707e-06	1	0	A	31823216	A	A	31823216	3	1	236	1	0	0	0	0	1	0	0	0	11537	478	17	4	1050	4	PAX6	11	31823216	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	12746059	31823216	103183300	330	42968											
CRY2	1408	broad.mit.edu	37	chr11	45892072	45892072	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttaccagcagctttcgcgctAccggggactctgtaaggaga	9	9	12	11	3	1	1	0	0	1	1	2	3	1	2	2	3	4	4	2	3	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:45892072A>T	uc010rgn.1	+	9	1623	c.1601A>T	c.(1600-1602)TAC>TTC	p.Y534F	CRY2_uc009ykw.2_Missense_Mutation_p.Y452F|CRY2_uc010rgo.1_Missense_Mutation_p.Y256F	NM_021117	NP_066940	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like) isoform 1	513					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			central_nervous_system(1)	1						CTTTCGCGCTACCGGGGACTC	0.542													8	29					0	0	0	0	T	45892072	T	T	45892072	3	4	236	1	0	0	0	0	1	0	0	0	3919	391	14	5	1671	5	CRY2	11	45892072	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	14068856	45892072	89114444	331	42969											
PTPRJ	5795	broad.mit.edu	37	chr11	48168496	48168496	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgactgtgggaggcttcAtcttctggagaaagaagagg	10	11	15	5	0	3	4	1	1	2	3	3	6	3	5	0	4	0	1	0	4	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:48168496A>G	uc001ngp.3	+	15	3335	c.2980A>G	c.(2980-2982)ATC>GTC	p.I994V		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	994	Helical; (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						GGGAGGCTTCATCTTCTGGAG	0.398													96	115					0	0	0	0	G	48168496	G	G	48168496	3	3	236	1	0	0	0	0	1	0	0	0	12869	217	8	5	3047	5	PTPRJ	11	48168496	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	2276424	48168496	86838020	332	42970											
OR4C12	283093	broad.mit.edu	37	chr11	50003578	50003578	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagagaatctgaatagttgCatgaagaaatcctcccaccc	16	8	7	10	0	1	4	0	2	1	2	3	5	3	4	3	0	1	2	3	0	6	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:50003578C>T	uc010ria.1	-	1	460	c.460G>A	c.(460-462)GCA>ACA	p.A154T		NM_001005270	NP_001005270	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TGAATAGTTGCATGAAGAAAT	0.478													42	162					0	0	0	0	T	50003578	T	T	50003578	3	4	236	1	0	0	0	0	1	0	0	0	11100	710	25	4	473	4	OR4C12	11	50003578	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1835082	50003578	85002938	333	42971											
OR4C46	119749	broad.mit.edu	37	chr11	51515337	51515337	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggggcttacagagaatcCaaagatgcagaaaatcatat	16	8	10	7	0	1	3	1	0	0	3	2	4	2	3	1	2	2	3	1	2	6	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:51515337C>A	uc010ric.1	+	1	56	c.56C>A	c.(55-57)CCA>CAA	p.P19Q		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACAGAGAATCCAAAGATGCAG	0.363													20	98					0.000175454	0.000264664	1	0	A	51515337	A	A	51515337	3	1	236	1	0	0	0	0	1	0	0	0	11105	594	21	4	58	4	OR4C46	11	51515337	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1511759	51515337	83491179	334	42972											
TRIM48	79097	broad.mit.edu	37	chr11	55035843	55035843	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caggcttttggagacatattAtacaggtgagtatgtacctg	11	13	11	6	0	0	2	0	1	0	1	0	3	0	2	1	3	2	3	1	3	5	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:55035843A>T	uc010rid.1	+	4	659	c.573A>T	c.(571-573)TTA>TTT	p.L191F		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	175						intracellular	zinc ion binding				0						GAGACATATTATACAGGTGAG	0.338													12	46					0	0	0	0	T	55035843	T	T	55035843	3	4	236	1	0	0	0	0	1	0	0	0	16590	446	16	5	587	5	TRIM48	11	55035843	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	3520506	55035843	79970673	335	42973											
OR5I1	10798	broad.mit.edu	37	chr11	55703379	55703379	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgtcacaatatttcagaatAaaggcaaaggatgtgtgaac	16	11	9	5	0	2	2	2	1	0	1	2	3	2	3	0	2	1	1	0	2	7	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:55703379A>G	uc010ris.1	-	1	498	c.498T>C	c.(496-498)TTT>TTC	p.F166F		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATTTCAGAATAAAGGCAAAGG	0.413													28	28					0	0	0	0	G	55703379	G	G	55703379	2	3	236	1	0	0	0	0	0	0	0	1	11218	359	13	5		5	OR5I1	11	55703379	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	667536	55703379	79303137	336	42974											
OR5I1	10798	broad.mit.edu	37	chr11	55703773	55703773	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaattatagcatacaatGtcagaaacatgaggaacagg	18	8	9	6	0	2	3	2	1	0	2	2	4	2	4	0	2	4	1	0	2	7	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:55703773G>A	uc010ris.1	-	1	104	c.104C>T	c.(103-105)ACA>ATA	p.T35I		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGCATACAATGTCAGAAACAT	0.393													8	28					0	0	0	0	A	55703773	A	A	55703773	3	1	236	1	0	0	0	0	1	0	0	0	11218	1377	48	4	843	4	OR5I1	11	55703773	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	394	55703773	79302743	337	42975											
OR5T3	390154	broad.mit.edu	37	chr11	56020200	56020200	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagtctatgtgccactcatCactgcttcctacgttgctgg	7	13	9	12	1	3	1	2	0	1	1	4	1	4	1	2	1	4	3	2	1	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:56020200C>T	uc010rjd.1	+	1	525	c.525C>T	c.(523-525)ATC>ATT	p.I175I		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	175	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TGCCACTCATCACTGCTTCCT	0.433													99	120					0	0	0	0	T	56020200	T	T	56020200	2	4	236	1	0	0	0	0	0	0	0	1	11237	816	29	2		2	OR5T3	11	56020200	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	316427	56020200	78986316	338	42976											
OR8J1	219477	broad.mit.edu	37	chr11	56127929	56127929	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgcaacatctggctctcatTaatcttggtaactctactgt	9	15	6	11	0	4	0	1	0	4	0	5	0	4	0	0	2	4	3	0	2	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:56127929T>C	uc010rjh.1	+	1	207	c.207T>C	c.(205-207)ATT>ATC	p.I69I		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGGCTCTCATTAATCTTGGTA	0.453													27	108					0	0	0	0	C	56127929	C	C	56127929	2	2	236	1	0	0	0	0	0	0	0	1	11295	1742	61	5		5	OR8J1	11	56127929	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	107729	56127929	78878587	339	42977											
OR5M11	219487	broad.mit.edu	37	chr11	56309852	56309852	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcaaggcctgcttcacatcTttattcctcagactgtagat	9	15	6	11	0	4	2	3	0	1	2	5	2	5	2	2	1	1	2	2	1	3	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:56309852T>C	uc010rjl.1	-	1	882	c.882A>G	c.(880-882)AAA>AAG	p.K294K		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTTCACATCTTTATTCCTCA	0.373													11	40					0	0	0	0	C	56309852	C	C	56309852	2	2	236	1	0	0	0	0	0	0	0	1	11228	1606	56	5		5	OR5M11	11	56309852	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	181923	56309852	78696664	340	42978											
OR5M1	390168	broad.mit.edu	37	chr11	56380575	56380575	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagatgttcttggacatcCtggaactgtaatgcaaaggg	12	10	11	8	0	1	1	0	0	1	1	2	3	2	3	1	3	2	3	1	3	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:56380575C>A	uc001nja.1	-	1	404	c.404G>T	c.(403-405)AGG>ATG	p.R135M		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						CTTGGACATCCTGGAACTGTA	0.453													34	50					9.65963e-10	1.65546e-09	1	0	A	56380575	A	A	56380575	3	1	236	1	0	0	0	0	1	0	0	0	11226	681	24	4	547	4	OR5M1	11	56380575	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	70723	56380575	78625941	341	42979											
SMTNL1	219537	broad.mit.edu	37	chr11	57313764	57313764	+	Frame_Shift_Del	DEL	G	-	-																															aggcagccggggcagccattGgtggtgtcaagaacatgctc																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:57313764delG	uc009ymh.1	+	6	1186	c.1186delG	c.(1186-1188)GGTfs	p.G396fs		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	378										ovary(1)	1						GGCAGCCATTGGTGGTGTCAA	0.637													---	---	---								-	57313764	-	-	57313764	7	5	236	1	0	1	0	1	0	0	0	0	14879	1348	47	0	1208	0	SMTNL1	11	57313764	Frame_Shift_Del	DEL	G	TCGA-CV-7245-01A-11D-2012-08	933189	57313764	77692752	342	42980											
OR5B3	441608	broad.mit.edu	37	chr11	58170806	58170806	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agatgaaggggaacgttataAagaggggaacctgcagttct	14	8	14	5	1	1	3	0	1	1	2	1	5	1	5	1	4	3	3	1	4	6	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:58170806A>G	uc010rkf.1	-	1	77	c.77T>C	c.(76-78)TTT>TCT	p.F26S		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GAACGTTATAAAGAGGGGAAC	0.413													24	68					0	0	0	0	G	58170806	G	G	58170806	3	3	236	1	0	0	0	0	1	0	0	0	11206	14	1	5	869	5	OR5B3	11	58170806	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	857042	58170806	76835710	343	42981											
TUT1	64852	broad.mit.edu	37	chr11	62343587	62343587	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagattcagggggccaaggCgcagaccctcccagagatta	11	5	14	11	1	1	3	1	0	0	3	2	5	2	3	3	4	0	1	3	4	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:62343587C>T	uc001nto.2	-	9	1756	c.1718G>A	c.(1717-1719)CGC>CAC	p.R573H	EEF1G_uc001ntm.1_5'Flank|EEF1G_uc010rlw.1_5'Flank|TUT1_uc001ntp.1_Missense_Mutation_p.R69H	NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	535	PAP-associated.				mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						GGGGCCAAGGCGCAGACCCTC	0.622													11	39					0	0	0	0	T	62343587	T	T	62343587	3	4	236	1	0	0	0	0	1	0	0	0	16848	768	27	1	1024	1	TUT1	11	62343587	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4172781	62343587	72662929	344	42982											
SLC22A11	55867	broad.mit.edu	37	chr11	64335111	64335111	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actatgggctggtcttcgacCtgcagagcctgggccgtgac	6	9	14	12	2	1	2	0	1	1	1	2	3	1	2	3	3	2	2	3	3	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:64335111C>A	uc001oai.2	+	7	1473	c.1099C>A	c.(1099-1101)CTG>ATG	p.L367M	SLC22A11_uc001oaj.2_Missense_Mutation_p.L367M|SLC22A11_uc009ypq.2_Intron	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	367	Helical; (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	GGTCTTCGACCTGCAGAGCCT	0.632													80	80					5.95195e-44	1.25966e-43	1	0	A	64335111	A	A	64335111	3	1	236	1	0	0	0	0	1	0	0	0	14507	680	24	4	1125	4	SLC22A11	11	64335111	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1991524	64335111	70671405	345	42983											
SLC22A12	116085	broad.mit.edu	37	chr11	64367324	64367324	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgcatccctgttgctggCagggctctgcattctggcca	4	10	13	14	1	2	0	0	0	2	0	3	0	3	0	3	4	2	6	3	4	0	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:64367324C>T	uc001oam.1	+	7	1994	c.1247C>T	c.(1246-1248)GCA>GTA	p.A416V	SLC22A12_uc001oal.1_Missense_Mutation_p.A195V|SLC22A12_uc009yps.1_Missense_Mutation_p.A382V|SLC22A12_uc001oan.1_Missense_Mutation_p.A308V|SLC22A12_uc009ypt.2_Missense_Mutation_p.A234V	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	416	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CTGTTGCTGGCAGGGCTCTGC	0.657													8	33					0	0	0	0	T	64367324	T	T	64367324	3	4	236	1	0	0	0	0	1	0	0	0	14508	710	25	4	1273	4	SLC22A12	11	64367324	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	32213	64367324	70639192	346	42984											
RHOD	29984	broad.mit.edu	37	chr11	66834226	66834226	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggcaagatgactatgacCgcctgcggcccctgttctac	8	8	11	14	2	1	3	0	2	1	1	1	3	1	3	4	2	2	2	4	2	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:66834226C>T	uc001ojv.2	+	3	323	c.238C>T	c.(238-240)CGC>TGC	p.R80C		NM_014578	NP_055393	O00212	RHOD_HUMAN	ras homolog D precursor	80					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0						TGACTATGACCGCCTGCGGCC	0.592													31	115					0	0	0	0	T	66834226	T	T	66834226	3	4	236	1	0	0	0	0	1	0	0	0	13402	652	23	1	248	1	RHOD	11	66834226	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2466902	66834226	68172290	347	42985											
LRP5	4041	broad.mit.edu	37	chr11	68177399	68177399	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaccatcagccgcgccttCatgaacgggagctcggtgga	9	6	13	13	4	2	2	2	1	0	1	3	4	2	4	3	3	3	1	3	3	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:68177399C>T	uc001ont.2	+	10	2184	c.2109C>T	c.(2107-2109)TTC>TTT	p.F703F	LRP5_uc009ysg.2_Silent_p.F113F	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	703	LDL-receptor class B 11.|Beta-propeller 3.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GCCGCGCCTTCATGAACGGGA	0.488													24	59					0	0	0	0	T	68177399	T	T	68177399	2	4	236	1	0	0	0	0	0	0	0	1	9010	825	29	2		2	LRP5	11	68177399	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1343173	68177399	66829117	348	42986											
CPT1A	1374	broad.mit.edu	37	chr11	68540781	68540781	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcacaaaggcgtctgggctCgtgcgacatttcttgatgat	8	12	12	9	3	2	2	0	2	2	0	3	3	2	2	0	2	2	2	0	2	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:68540781C>T	uc001oog.3	-	14	1862	c.1692G>A	c.(1690-1692)ACG>ACA	p.T564T	CPT1A_uc001oof.3_Silent_p.T564T|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	564	Cytoplasmic (Potential).|Coenzyme A binding (By similarity).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CGTCTGGGCTCGTGCGACATT	0.527													11	47					0	0	0	0	T	68540781	T	T	68540781	2	4	236	1	0	0	0	0	0	0	0	1	3846	871	31	1		1	CPT1A	11	68540781	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	363382	68540781	66465735	349	42987											
GDPD5	81544	broad.mit.edu	37	chr11	75150960	75150960	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgcccacgatgagggtgaagGagaccaggtcggcagtgacc	10	5	16	10	2	0	4	0	3	0	1	1	6	0	4	3	4	1	1	3	4	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:75150960G>T	uc001owo.3	-	16	2057	c.1520C>A	c.(1519-1521)TCC>TAC	p.S507Y	GDPD5_uc001owp.3_Missense_Mutation_p.S507Y|GDPD5_uc001own.3_Missense_Mutation_p.S262Y|GDPD5_uc009yuc.2_Missense_Mutation_p.S369Y|GDPD5_uc009yud.2_Missense_Mutation_p.S388Y	NM_030792	NP_110419	Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain	507	Helical; (Potential).				glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			ovary(1)	1						GAGGGTGAAGGAGACCAGGTC	0.627													18	57					6.49762e-13	1.1816e-12	1	0	T	75150960	T	T	75150960	3	4	236	1	0	0	0	0	1	0	0	0	6364	1174	41	2	309	2	GDPD5	11	75150960	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	6610179	75150960	59855556	350	42988											
AMOTL1	154810	broad.mit.edu	37	chr11	94533100	94533100	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggacaggcgcataaggacgaGgcgctgaaggaactgaagca	14	3	16	8	3	0	2	0	2	0	0	0	6	0	5	0	5	2	3	0	5	4	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:94533100G>T	uc001pfb.2	+	3	914	c.744G>T	c.(742-744)GAG>GAT	p.E248D	AMOTL1_uc001pfc.2_Missense_Mutation_p.E198D	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	248						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				ATAAGGACGAGGCGCTGAAGG	0.612													11	47					1.08611e-07	1.7776e-07	1	0	T	94533100	T	T	94533100	3	4	236	1	0	0	0	0	1	0	0	0	583	991	35	4	754	4	AMOTL1	11	94533100	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	19382140	94533100	40473416	351	42989											
KIAA1377	57562	broad.mit.edu	37	chr11	101834402	101834402	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accatcactgccatcatattGttcttcagagtgccaaactt	11	13	5	12	0	4	1	3	0	1	1	4	1	4	1	3	0	3	1	3	0	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:101834402G>C	uc001pgm.2	+	6	2906	c.2636G>C	c.(2635-2637)TGT>TCT	p.C879S	KIAA1377_uc001pgn.2_Missense_Mutation_p.C835S|KIAA1377_uc010run.1_Missense_Mutation_p.C680S|KIAA1377_uc009yxa.1_Missense_Mutation_p.C680S	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	879							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CCATCATATTGTTCTTCAGAG	0.418													24	18					0	0	0	0	C	101834402	C	C	101834402	3	2	236	1	0	0	0	0	1	0	0	0	8266	1377	48	4	2658	4	KIAA1377	11	101834402	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	7301302	101834402	33172114	352	42990											
CASP4	837	broad.mit.edu	37	chr11	104819393	104819393	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagtctctgacccacagttcCccacggtttgctatggagac	8	10	10	13	1	1	2	0	1	1	1	3	4	2	2	3	2	1	3	3	2	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:104819393C>A	uc001pid.1	-	6	865	c.792G>T	c.(790-792)GGG>GGT	p.G264G	CASP4_uc001pib.1_Silent_p.G208G|CASP4_uc009yxg.1_Silent_p.G173G	NM_001225	NP_001216	P49662	CASP4_HUMAN	caspase 4 isoform alpha precursor	264					apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			lung(2)|ovary(1)|skin(1)	4		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		CCCACAGTTCCCCACGGTTTG	0.493													18	44					1.67942e-08	2.79998e-08	1	0	A	104819393	A	A	104819393	2	1	236	1	0	0	0	0	0	0	0	1	2685	610	22	4		4	CASP4	11	104819393	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2984991	104819393	30187123	353	42991											
GRIA4	2893	broad.mit.edu	37	chr11	105774688	105774688	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggggccagggaattgacaTggagaggacactcaaacagg	14	5	15	7	0	1	2	1	1	0	1	1	5	1	4	1	6	1	0	1	6	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:105774688T>C	uc001pix.2	+	8	1480	c.1034T>C	c.(1033-1035)ATG>ACG	p.M345T	GRIA4_uc001piu.1_Missense_Mutation_p.M345T|GRIA4_uc001piw.2_Missense_Mutation_p.M345T|GRIA4_uc009yxk.1_Missense_Mutation_p.M345T	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	345	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	GGAATTGACATGGAGAGGACA	0.398													18	76					0	0	0	0	C	105774688	C	C	105774688	3	2	236	1	0	0	0	0	1	0	0	0	6809	1464	51	5	1060	5	GRIA4	11	105774688	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	955295	105774688	29231828	354	42992											
AASDHPPT	60496	broad.mit.edu	37	chr11	105950303	105950303	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagttcttgcaaaggactCatcgaatccttacccgaatt	12	11	6	12	2	2	0	1	0	1	0	4	3	3	1	3	1	2	2	3	1	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:105950303C>G	uc001pjc.1	+	2	439	c.293C>G	c.(292-294)TCA>TGA	p.S98*	KBTBD3_uc001pja.2_5'Flank|KBTBD3_uc001pjb.2_5'Flank|KBTBD3_uc009yxm.2_5'Flank|AASDHPPT_uc010rvn.1_RNA	NM_015423	NP_056238	Q9NRN7	ADPPT_HUMAN	aminoadipate-semialdehyde	98					macromolecule biosynthetic process|pantothenate metabolic process	cytosol	holo-[acyl-carrier-protein] synthase activity|magnesium ion binding|protein binding				0		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.78e-05)|Epithelial(105;0.00622)|all cancers(92;0.041)		GCAAAGGACTCATCGAATCCT	0.388													14	42					0	0	0	0	G	105950303	G	G	105950303	4	3	236	1	0	0	0	0	0	1	0	0	23	838	29	2	299	2	AASDHPPT	11	105950303	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	175615	105950303	29056213	355	42993											
ARHGAP20	57569	broad.mit.edu	37	chr11	110485323	110485323	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccttggcgaagattttgaGgggaatgctcttcgggtagt	7	13	15	6	2	1	2	0	1	1	1	3	4	2	3	1	4	1	2	1	4	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:110485323G>C	uc001pkz.1	-	7	877	c.592C>G	c.(592-594)CTC>GTC	p.L198V	ARHGAP20_uc001pky.1_Missense_Mutation_p.L175V|ARHGAP20_uc009yyb.1_Missense_Mutation_p.L162V|ARHGAP20_uc001pla.1_Missense_Mutation_p.L162V	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	198	Ras-associating.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		AAGATTTTGAGGGGAATGCTC	0.413													10	35					0	0	0	0	C	110485323	C	C	110485323	3	2	236	1	0	0	0	0	1	0	0	0	870	1000	35	4	3023	4	ARHGAP20	11	110485323	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4535020	110485323	24521193	356	42994											
BCL9L	283149	broad.mit.edu	37	chr11	118772310	118772310	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaggatccatctgtcggtgCgcctgcatcatccgctccat	6	10	10	15	3	2	0	1	0	1	0	6	1	5	1	4	2	2	3	4	2	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:118772310C>A	uc001pug.2	-	6	3107	c.2142G>T	c.(2140-2142)GCG>GCT	p.A714A	BCL9L_uc009zal.2_Silent_p.A709A	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	714	Met-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TCTGTCGGTGCGCCTGCATCA	0.662													20	54					5.35267e-07	8.70251e-07	1	0	A	118772310	A	A	118772310	2	1	236	1	0	0	0	0	0	0	0	1	1384	755	27	3		3	BCL9L	11	118772310	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	8286987	118772310	16234206	357	42995											
VPS11	55823	broad.mit.edu	37	chr11	118944567	118944567	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accttgccaagagccagcatCtggacagtgatgggctggcc	9	7	13	12	0	1	2	0	1	1	1	1	3	1	3	4	3	3	2	4	3	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:118944567C>G	uc010ryx.1	+	8	1186	c.1144C>G	c.(1144-1146)CTG>GTG	p.L382V	VPS11_uc010ryy.1_Missense_Mutation_p.L228V	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	382					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GAGCCAGCATCTGGACAGTGA	0.478													7	24					0	0	0	0	G	118944567	G	G	118944567	3	3	236	1	0	0	0	0	1	0	0	0	17256	912	32	2	1169	2	VPS11	11	118944567	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	172257	118944567	16061949	358	42996											
ST3GAL4	6484	broad.mit.edu	37	chr11	126283417	126283417	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagaagcccaccacgggcctGttggccatcacgctggccct	7	6	11	17	2	1	1	1	0	0	1	1	1	1	1	5	3	1	2	5	3	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:126283417G>C	uc001qds.2	+	10	1008	c.789G>C	c.(787-789)CTG>CTC	p.L263L	ST3GAL4_uc001qdt.2_Silent_p.L259L|ST3GAL4_uc009zcc.2_Silent_p.L99L|ST3GAL4_uc009zcd.2_Silent_p.L252L|ST3GAL4_uc001qdu.2_Silent_p.L259L|ST3GAL4_uc001qdv.2_Silent_p.L263L|ST3GAL4_uc009zce.2_Silent_p.L259L|ST3GAL4_uc001qdw.2_Silent_p.L252L|ST3GAL4_uc001qdx.1_Intron|ST3GAL4_uc001qdy.2_Silent_p.L99L|ST3GAL4_uc001qdz.2_Silent_p.L99L	NM_006278	NP_006269	Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	263	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		CCACGGGCCTGTTGGCCATCA	0.527													13	27					0	0	0	0	C	126283417	C	C	126283417	2	2	236	1	0	0	0	0	0	0	0	1	15283	1364	48	4		4	ST3GAL4	11	126283417	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	7338850	126283417	8723099	359	42997											
NFRKB	4798	broad.mit.edu	37	chr11	129758530	129758530	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgcagagggtttccaaagCggaagttctccccactgaac	10	9	11	11	1	1	2	0	1	1	1	3	3	2	3	3	2	3	3	3	2	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr11:129758530C>A	uc001qfi.2	-	4	497	c.296G>T	c.(295-297)CGC>CTC	p.R99L	NFRKB_uc001qfg.2_Missense_Mutation_p.R112L|NFRKB_uc001qfh.2_Missense_Mutation_p.R122L|NFRKB_uc010sbw.1_Missense_Mutation_p.R99L	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	99					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GTTTCCAAAGCGGAAGTTCTC	0.502													19	43					2.27731e-05	3.52175e-05	1	0	A	129758530	A	A	129758530	3	1	236	1	0	0	0	0	1	0	0	0	10438	768	27	3	3735	3	NFRKB	11	129758530	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3475113	129758530	5247986	360	42998											
GALNT8	26290	broad.mit.edu	37	chr12	4835951	4835951	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tacaacgcgtacctcagcaaCcagctgcctctcaatcgcac	11	7	6	17	3	2	0	2	0	1	0	4	0	2	0	3	0	7	4	3	0	5	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:4835951C>T	uc001qne.1	+	2	557	c.465C>T	c.(463-465)AAC>AAT	p.N155N		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	155	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						ACCTCAGCAACCAGCTGCCTC	0.567													37	76					0	0	0	0	T	4835951	T	T	4835951	2	4	236	1	0	0	0	0	0	0	0	1	6254	506	18	4		4	GALNT8	12	4835951	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08		4835951	129015944	361	42999											
KCNA1	3736	broad.mit.edu	37	chr12	5021762	5021762	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgccctgcccgtacctgtCattgtgtccaatttcaacta	8	14	6	13	1	2	0	2	0	0	0	3	0	3	0	4	0	4	1	4	0	4	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:5021762C>T	uc001qnh.2	+	2	2323	c.1218C>T	c.(1216-1218)GTC>GTT	p.V406V		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	406	Helical; Name=Segment S6; (Potential).				synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CCGTACCTGTCATTGTGTCCA	0.517													170	304					0	0	0	0	T	5021762	T	T	5021762	2	4	236	1	0	0	0	0	0	0	0	1	8040	813	29	2		2	KCNA1	12	5021762	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	185811	5021762	128830133	362	43000											
CD163	9332	broad.mit.edu	37	chr12	7636247	7636247	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacgtccagaacaggaagtgGgtccttcctgaagtcttatc	10	10	10	11	1	1	2	0	1	1	1	5	3	4	3	3	2	1	0	3	2	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:7636247G>C	uc001qsz.3	-	12	2932	c.2804C>G	c.(2803-2805)CCC>CGC	p.P935R	CD163_uc001qta.3_Missense_Mutation_p.P935R|CD163_uc009zfw.2_Missense_Mutation_p.P968R	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	935	SRCR 9.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						ACAGGAAGTGGGTCCTTCCTG	0.468													23	55					0	0	0	0	C	7636247	C	C	7636247	3	2	236	1	0	0	0	0	1	0	0	0	2982	1232	43	4	686	4	CD163	12	7636247	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2614485	7636247	126215648	363	43001											
A2M	2	broad.mit.edu	37	chr12	9230012	9230012	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtcacttcatcttctactCctccctgtgaatacgagaga	9	12	8	12	1	4	2	2	1	2	1	6	4	6	2	2	1	2	0	2	1	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:9230012C>A	uc001qvk.1	-	27	3394	c.3281G>T	c.(3280-3282)GGA>GTA	p.G1094V	A2M_uc001qvj.1_Missense_Mutation_p.G136V|A2M_uc009zgk.1_Missense_Mutation_p.G944V	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1094					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	ATCTTCTACTCCTCCCTGTGA	0.453													7	24					7.48243e-07	1.2125e-06	1	0	A	9230012	A	A	9230012	3	1	236	1	0	0	0	0	1	0	0	0	4	855	30	2	1183	2	A2M	12	9230012	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1593765	9230012	124621883	364	43002											
CLEC1B	51266	broad.mit.edu	37	chr12	10147807	10147807	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttctggcgagataatccGacccaacgaattaaatgagt	14	9	9	9	3	1	2	0	1	1	1	2	6	2	2	2	1	1	0	2	1	5	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:10147807G>T	uc001qwu.2	-	5	677	c.477C>A	c.(475-477)GTC>GTA	p.V159V	CLEC1B_uc009zhd.2_Silent_p.V126V	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	159	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						GAGATAATCCGACCCAACGAA	0.433													73	406					1.75807e-36	3.66544e-36	1	0	T	10147807	T	T	10147807	2	4	236	1	0	0	0	0	0	0	0	1	3521	1045	37	3		3	CLEC1B	12	10147807	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	917795	10147807	123704088	365	43003											
PDE3A	5139	broad.mit.edu	37	chr12	20769241	20769241	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaccacctcggccacaggTctacccaccttggagcctgc	8	6	8	19	1	1	0	0	0	1	0	2	1	1	1	7	3	3	0	7	3	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:20769241T>C	uc001reh.1	+	4	1369	c.1347T>C	c.(1345-1347)GGT>GGC	p.G449G		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	449					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CGGCCACAGGTCTACCCACCT	0.562													35	82					0	0	0	0	C	20769241	C	C	20769241	2	2	236	1	0	0	0	0	0	0	0	1	11691	1654	58	5		5	PDE3A	12	20769241	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	10621434	20769241	113082654	366	43004											
SLCO1C1	53919	broad.mit.edu	37	chr12	20874784	20874784	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccccagtgggtaggagcctgGtggcttggctatctaatagc	7	10	14	10	0	1	0	0	0	1	0	1	1	1	1	3	5	2	3	3	5	4	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:20874784G>T	uc001rej.3	+	9	1177	c.822G>T	c.(820-822)TGG>TGT	p.W274C	SLCO1C1_uc010sii.1_Missense_Mutation_p.W274C|SLCO1C1_uc010sij.1_Missense_Mutation_p.W225C|SLCO1C1_uc009zip.2_Missense_Mutation_p.W108C|SLCO1C1_uc001rei.2_Missense_Mutation_p.W274C|SLCO1C1_uc010sik.1_Missense_Mutation_p.W156C	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	274	Helical; Name=6; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TAGGAGCCTGGTGGCTTGGCT	0.423													18	32					2.4624e-09	4.19804e-09	1	0	T	20874784	T	T	20874784	3	4	236	1	0	0	0	0	1	0	0	0	14789	1270	44	4	848	4	SLCO1C1	12	20874784	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	105543	20874784	112977111	367	43005											
OVCH1	341350	broad.mit.edu	37	chr12	29630038	29630038	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attcctcagttgcctaccttTataatgtgcttctctggagc	7	16	7	11	0	2	0	1	0	1	0	4	1	3	1	3	1	4	2	3	1	3	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:29630038T>C	uc001rix.1	-	12	1374	c.1374A>G	c.(1372-1374)ATA>ATG	p.I458M		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	458	CUB 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TGCCTACCTTTATAATGTGCT	0.393													8	20					0	0	0	0	C	29630038	C	C	29630038	3	2	236	1	0	0	0	0	1	0	0	0	11377	1744	61	5	2098	5	OVCH1	12	29630038	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	8755254	29630038	104221857	368	43006											
KIF21A	55605	broad.mit.edu	37	chr12	39716684	39716684	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtggtggttctccttcgggCctagtcaaagaatggaagga	10	10	14	7	1	2	1	1	0	1	1	4	3	2	3	2	5	0	1	2	5	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:39716684C>A	uc001rly.2	-	27	3603	c.3457G>T	c.(3457-3459)GCC>TCC	p.A1153S	KIF21A_uc001rlv.2_Missense_Mutation_p.A158S|KIF21A_uc001rlw.2_Missense_Mutation_p.A470S|KIF21A_uc001rlx.2_Missense_Mutation_p.A1140S|KIF21A_uc001rlz.2_Missense_Mutation_p.A1117S|KIF21A_uc010skl.1_Missense_Mutation_p.A1133S	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1153					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CTCCTTCGGGCCTAGTCAAAG	0.433													23	73					3.62473e-10	6.25569e-10	1	0	A	39716684	A	A	39716684	3	1	236	1	0	0	0	0	1	0	0	0	8327	753	26	4	1615	4	KIF21A	12	39716684	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	10086646	39716684	94135211	369	43007											
KIF21A	55605	broad.mit.edu	37	chr12	39724658	39724658	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cactggttatttctgtttgtTtgagtcgaccttccagtact	6	18	8	9	1	1	1	0	1	1	0	3	2	2	1	2	1	1	4	2	1	2	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:39724658T>G	uc001rly.2	-	23	3355	c.3209A>C	c.(3208-3210)AAA>ACA	p.K1070T	KIF21A_uc001rlv.2_Missense_Mutation_p.K82T|KIF21A_uc001rlw.2_Missense_Mutation_p.K387T|KIF21A_uc001rlx.2_Missense_Mutation_p.K1057T|KIF21A_uc001rlz.2_Missense_Mutation_p.K1034T|KIF21A_uc010skl.1_Missense_Mutation_p.K1057T	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1070	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TTCTGTTTGTTTGAGTCGACC	0.403													14	55					0	0	0	0	G	39724658	G	G	39724658	3	3	236	1	0	0	0	0	1	0	0	0	8327	1841	64	5	1879	5	KIF21A	12	39724658	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	7974	39724658	94127237	370	43008											
CNTN1	1272	broad.mit.edu	37	chr12	41418967	41418967	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagattcggtattgggctGcccatgacaaagaagaagct	12	9	12	8	1	0	4	0	1	0	3	1	4	0	4	1	2	3	4	1	2	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:41418967G>A	uc001rmm.1	+	21	2652	c.2539G>A	c.(2539-2541)GCC>ACC	p.A847T	CNTN1_uc001rmn.1_Missense_Mutation_p.A836T	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	847	Fibronectin type-III 3.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GTATTGGGCTGCCCATGACAA	0.433													37	174					0	0	0	0	A	41418967	A	A	41418967	3	1	236	1	0	0	0	0	1	0	0	0	3655	1319	46	4	2617	4	CNTN1	12	41418967	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1694309	41418967	92432928	371	43009											
FAM113B	91523	broad.mit.edu	37	chr12	47629873	47629873	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccccagatgcctgttttTcctcagaccatactttccag	7	13	6	15	0	1	2	1	0	0	2	4	2	4	2	6	0	2	1	6	0	1	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:47629873T>C	uc001rpn.2	+	4	1758	c.1027T>C	c.(1027-1029)TCC>CCC	p.S343P	FAM113B_uc001rpq.2_Missense_Mutation_p.S343P	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	343	Pro-rich.						hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					TGCCTGTTTTTCCTCAGACCA	0.393													13	207					0	0	0	0	C	47629873	C	C	47629873	3	2	236	1	0	0	0	0	1	0	0	0	5430	1783	62	5	1029	5	FAM113B	12	47629873	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	6210906	47629873	86222022	372	43010											
ACVRL1	94	broad.mit.edu	37	chr12	52312877	52312877	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcagacccccaccatccCtaaccggctggctgcagacc	9	5	8	19	1	1	2	1	0	0	2	2	2	2	2	6	2	3	4	6	2	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:52312877C>A	uc001rzj.2	+	9	1638	c.1355C>A	c.(1354-1356)CCT>CAT	p.P452H	ACVRL1_uc001rzk.2_Missense_Mutation_p.P452H|ACVRL1_uc010snm.1_Missense_Mutation_p.P278H	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	452	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CCCACCATCCCTAACCGGCTG	0.587									Hereditary_Hemorrhagic_Telangiectasia				19	62					1.56452e-12	2.8294e-12	1	0	A	52312877	A	A	52312877	3	1	236	1	0	0	0	0	1	0	0	0	225	681	24	4	1385	4	ACVRL1	12	52312877	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4683004	52312877	81539018	373	43011											
KRT85	3891	broad.mit.edu	37	chr12	52756641	52756641	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcctccacagaccccacctgGcacttggcattctcaatctc	8	10	5	18	0	2	1	1	0	2	1	6	1	4	1	5	2	0	2	5	2	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:52756641G>T	uc001sag.2	-	6	1194	c.1074C>A	c.(1072-1074)TGC>TGA	p.C358*		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	358	Rod.|Coil 2.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		ACCCCACCTGGCACTTGGCAT	0.597													57	97					3.89483e-19	7.66477e-19	1	0	T	52756641	T	T	52756641	4	4	236	1	0	0	0	0	0	1	0	0	8538	1195	42	4	465	4	KRT85	12	52756641	Nonsense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	443764	52756641	81095254	374	43012											
OR10A7	121364	broad.mit.edu	37	chr12	55614811	55614811	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaaactcatctaagatatGatctgtgaaaatcacaccag	17	9	7	8	0	4	4	2	2	2	2	4	5	4	4	1	0	1	0	1	0	5	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:55614811G>C	uc010spf.1	+	1	3	c.3G>C	c.(1-3)ATG>ATC	p.M1I		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						TCTAAGATATGATCTGTGAAA	0.313													24	108					0	0	0	0	C	55614811	C	C	55614811	3	2	236	1	0	0	0	0	1	0	0	0	10949	1290	45	2	5	2	OR10A7	12	55614811	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2858170	55614811	78237084	375	43013											
LRP1	4035	broad.mit.edu	37	chr12	57578167	57578167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgagcggtctcggctagatGgcacggagcgtgtggtgctg	5	10	18	8	4	1	2	0	1	1	1	2	3	1	3	0	5	3	3	0	5	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:57578167G>A	uc001snd.2	+	38	6584	c.6118G>A	c.(6118-6120)GGC>AGC	p.G2040S		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2040	LDL-receptor class B 19.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TCGGCTAGATGGCACGGAGCG	0.597													27	49					0	0	0	0	A	57578167	A	A	57578167	3	1	236	1	0	0	0	0	1	0	0	0	9001	1348	47	4	6268	4	LRP1	12	57578167	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1963356	57578167	76273728	376	43014											
KIF5A	3798	broad.mit.edu	37	chr12	57969038	57969038	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgggagctctcatcctgcCagctcctcatctctcaggtg	5	10	11	15	1	4	0	3	0	2	0	8	1	6	1	3	3	3	2	3	3	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:57969038C>G	uc001sor.1	+	16	2096	c.1888C>G	c.(1888-1890)CAG>GAG	p.Q630E	KIF5A_uc010srr.1_Missense_Mutation_p.Q541E	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	630					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						CTCATCCTGCCAGCTCCTCAT	0.552													3	20					0	0	0	0	G	57969038	G	G	57969038	3	3	236	1	0	0	0	0	1	0	0	0	8344	595	21	4	1950	4	KIF5A	12	57969038	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	390871	57969038	75882857	377	43015											
FAM19A2	338811	broad.mit.edu	37	chr12	62147483	62147483	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttacattcttctccctctaGacatggctgcatatggcacc	8	14	6	13	0	3	1	0	0	3	1	4	1	3	1	2	2	2	3	2	2	3	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:62147483G>T	uc001sqw.2	-	4	1817	c.304C>A	c.(304-306)CTA>ATA	p.L102I	FAM19A2_uc001sqv.2_RNA|FAM19A2_uc001sqx.2_Missense_Mutation_p.L102I|FAM19A2_uc001sqy.2_RNA	NM_178539	NP_848634	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine	102						cytoplasm				ovary(1)	1			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		TCTCCCTCTAGACATGGCTGC	0.403													37	79					6.03168e-27	1.23142e-26	1	0	T	62147483	T	T	62147483	3	4	236	1	0	0	0	0	1	0	0	0	5560	933	33	2	99	2	FAM19A2	12	62147483	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4178445	62147483	71704412	378	43016											
C12orf66	144577	broad.mit.edu	37	chr12	64587735	64587735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctctcagatttctttgactCaaaaatgatgacaatggtaa	14	14	6	7	0	4	4	2	3	2	1	5	4	4	4	0	1	0	1	0	1	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:64587735C>T	uc001srw.3	-	3	1284	c.1225G>A	c.(1225-1227)GAG>AAG	p.E409K	C12orf66_uc009zql.2_Missense_Mutation_p.E356K	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	409										ovary(1)	1						TTCTTTGACTCAAAAATGATG	0.443													55	112					0	0	0	0	T	64587735	T	T	64587735	3	4	236	1	0	0	0	0	1	0	0	0	1715	835	29	2	116	2	C12orf66	12	64587735	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2440252	64587735	69264160	379	43017											
IFNG	3458	broad.mit.edu	37	chr12	68551716	68551716	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataattagtcagcttttcgaAgtcatctcgtttctttttgt	8	20	6	7	2	4	0	2	0	2	0	6	1	4	0	0	0	1	2	0	0	3	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:68551716A>T	uc001stw.1	-	3	469	c.343T>A	c.(343-345)TTC>ATC	p.F115I		NM_000619	NP_000610	P01579	IFNG_HUMAN	interferon, gamma precursor	115					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	AGCTTTTCGAAGTCATCTCGT	0.368													24	94					0	0	0	0	T	68551716	T	T	68551716	3	4	236	1	0	0	0	0	1	0	0	0	7587	72	3	5	165	5	IFNG	12	68551716	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	3963981	68551716	65300179	380	43018											
IL26	55801	broad.mit.edu	37	chr12	68595635	68595635	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggctttggtttactgactgCtttccaataattttttaatc	8	20	6	7	0	0	1	0	1	0	0	2	1	1	1	1	2	2	3	1	2	4	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:68595635C>T	uc001stx.1	-	5	541	c.506G>A	c.(505-507)AGC>AAC	p.S169N		NM_018402	NP_060872	Q9NPH9	IL26_HUMAN	interleukin 26 precursor	169					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		TTACTGACTGCTTTCCAATAA	0.294													19	30					0	0	0	0	T	68595635	T	T	68595635	3	4	236	1	0	0	0	0	1	0	0	0	7718	797	28	4	13	4	IL26	12	68595635	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	43919	68595635	65256260	381	43019											
TPH2	121278	broad.mit.edu	37	chr12	72425354	72425354	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatacttcaatccctacaCacagagtattgaaattctga	15	12	5	9	0	2	3	1	2	1	1	3	3	3	3	1	0	2	2	1	0	6	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:72425354C>T	uc009zrw.1	+	11	1493	c.1352C>T	c.(1351-1353)ACA>ATA	p.T451I	TPH2_uc001swy.2_Missense_Mutation_p.T361I	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	451					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	AATCCCTACACACAGAGTATT	0.408													15	72					0	0	0	0	T	72425354	T	T	72425354	3	4	236	1	0	0	0	0	1	0	0	0	16469	478	17	4	1394	4	TPH2	12	72425354	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3829719	72425354	61426541	382	43020											
TRHDE	29953	broad.mit.edu	37	chr12	72771839	72771839	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggactatgctctccatataaCaaagagattaatagaatttt	16	13	6	6	0	1	2	0	0	1	2	2	4	1	3	1	1	2	1	1	1	7	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:72771839C>G	uc001sxa.2	+	3	1148	c.1118C>G	c.(1117-1119)ACA>AGA	p.T373R		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	373	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CTCCATATAACAAAGAGATTA	0.333													21	88					0	0	0	0	G	72771839	G	G	72771839	3	3	236	1	0	0	0	0	1	0	0	0	16546	478	17	4	1128	4	TRHDE	12	72771839	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	346485	72771839	61080056	383	43021											
TMTC2	160335	broad.mit.edu	37	chr12	83251085	83251085	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgatgtttgcttctcaccCcattcacacggaggcagtgg	7	12	10	12	1	2	1	2	1	1	0	3	2	2	2	2	3	1	3	2	3	0	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:83251085C>G	uc001szt.2	+	2	812	c.380C>G	c.(379-381)CCC>CGC	p.P127R	TMTC2_uc001szr.1_Missense_Mutation_p.P127R|TMTC2_uc001szs.1_Missense_Mutation_p.P127R|TMTC2_uc010suk.1_Intron	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	127	Helical; (Potential).					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						GCTTCTCACCCCATTCACACG	0.517													18	69					0	0	0	0	G	83251085	G	G	83251085	3	3	236	1	0	0	0	0	1	0	0	0	16327	623	22	4	386	4	TMTC2	12	83251085	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	10479246	83251085	50600810	384	43022											
CEP290	80184	broad.mit.edu	37	chr12	88478552	88478552	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggcaggcaatcgaagcctCagttcattgattactttgtc	9	13	10	9	1	2	1	2	1	0	0	4	2	2	1	1	2	2	3	1	2	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:88478552C>G	uc001tar.2	-	35	4859	c.4515G>C	c.(4513-4515)CTG>CTC	p.L1505L	CEP290_uc001taq.2_Silent_p.L565L	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1505					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						ATCGAAGCCTCAGTTCATTGA	0.363													20	56					0	0	0	0	G	88478552	G	G	88478552	2	3	236	1	0	0	0	0	0	0	0	1	3268	813	29	2		2	CEP290	12	88478552	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5227467	88478552	45373343	385	43023											
C12orf74	338809	broad.mit.edu	37	chr12	93101490	93101490	+	Nonstop_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggtgctatgacatctgttGactatttactattagatttt	9	18	7	7	1	1	3	0	2	1	1	1	3	1	3	1	1	2	2	1	1	5	9			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:93101490G>T	uc001tch.1	+	3	802	c.572G>T	c.(571-573)TGA>TTA	p.*191L	C12orf74_uc001tci.2_3'UTR	NM_001037671	NP_001032760	Q32Q52	CL074_HUMAN	hypothetical protein LOC338809	191											0						GACATCTGTTGACTATTTACT	0.363													6	32					0.00198382	0.00292949	1	0	T	93101490	T	T	93101490	4	4	236	1	0	0	0	0	0	0	0	0	1720	1285	45	2	593	2	C12orf74	12	93101490	Nonstop_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4622938	93101490	40750405	386	43024											
ELK3	2004	broad.mit.edu	37	chr12	96641260	96641260	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtccctgtcccccaactcAcccctcccttctgaacacag	7	8	4	22	1	2	1	1	1	1	0	5	1	5	1	7	0	2	0	7	0	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:96641260A>C	uc001teo.1	+	3	1029	c.750A>C	c.(748-750)TCA>TCC	p.S250S		NM_005230	NP_005221	P41970	ELK3_HUMAN	ELK3 protein	250					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	all_cancers(2;0.00173)					CCCCCAACTCACCCCTCCCTT	0.582													6	136					0	0	0	0	C	96641260	C	C	96641260	2	2	236	1	0	0	0	0	0	0	0	1	5084	146	6	5		5	ELK3	12	96641260	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	3539770	96641260	37210635	387	43025											
SSH1	54434	broad.mit.edu	37	chr12	109182593	109182593	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttgggtgacgattcttccTttattaccacttctgtgctg	5	18	8	10	1	3	1	0	1	3	0	4	2	4	1	2	1	2	1	2	1	2	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:109182593T>C	uc001tnm.2	-	15	2408	c.2321A>G	c.(2320-2322)AAG>AGG	p.K774R	SSH1_uc001tnl.2_Missense_Mutation_p.K462R	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	774					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						CGATTCTTCCTTTATTACCAC	0.468													65	89					0	0	0	0	C	109182593	C	C	109182593	3	2	236	1	0	0	0	0	1	0	0	0	15250	1609	56	5	832	5	SSH1	12	109182593	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	12541333	109182593	24669302	388	43026											
TRPV4	59341	broad.mit.edu	37	chr12	110230484	110230484	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatgatgctataggtcccCgtcagcttcagcccacgggt	8	10	10	13	2	3	1	3	1	0	0	4	1	4	1	3	2	3	2	3	2	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:110230484C>A	uc001tpj.1	-	10	1892	c.1797G>T	c.(1795-1797)ACG>ACT	p.T599T	TRPV4_uc001tpg.1_Silent_p.T565T|TRPV4_uc001tph.1_Silent_p.T552T|TRPV4_uc001tpi.1_Silent_p.T492T|TRPV4_uc001tpk.1_Silent_p.T599T|TRPV4_uc001tpl.1_Silent_p.T539T	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	599	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TATAGGTCCCCGTCAGCTTCA	0.577													22	41					1.87028e-06	2.96707e-06	1	0	A	110230484	A	A	110230484	2	1	236	1	0	0	0	0	0	0	0	1	16665	639	23	3		3	TRPV4	12	110230484	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1047891	110230484	23621411	389	43027											
HVCN1	84329	broad.mit.edu	37	chr12	111089187	111089187	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaactccaggcggaagaCaaataatttaaagatgatct	19	8	8	6	1	1	4	0	1	1	3	2	5	2	5	1	2	1	0	1	2	7	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:111089187C>G	uc001trs.1	-	6	643	c.478G>C	c.(478-480)GTC>CTC	p.V160L	HVCN1_uc001trq.1_Missense_Mutation_p.V160L|HVCN1_uc001trt.1_Missense_Mutation_p.V160L|HVCN1_uc010syd.1_Missense_Mutation_p.V140L	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	160	Cytoplasmic (Potential).				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						AGGCGGAAGACAAATAATTTA	0.468													32	54					0	0	0	0	G	111089187	G	G	111089187	3	3	236	1	0	0	0	0	1	0	0	0	7501	478	17	4	355	4	HVCN1	12	111089187	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	858703	111089187	22762708	390	43028											
FBXO21	23014	broad.mit.edu	37	chr12	117628083	117628083	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcacagctcgcgcagccgcCggcaggtgctggagacacgg	7	3	17	14	5	0	1	0	0	0	1	1	2	0	1	2	5	3	5	2	5	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	bdc58b10-1756-45bf-a34f-fa4095429476	g.chr12:117628083C>A	uc001twk.2	-	1	218	c.179G>T	c.(178-180)CGG>CTG	p.R60L	FBXO21_uc001twj.2_Missense_Mutation_p.R60L|FBXO21_uc009zwq.2_Missense_Mutation_p.R60L	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	60	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		GCGCAGCCGCCGGCAGGTGCT	0.572													5	12					5.9392e-07	9.10215e-07	1	0	A	117628083	A	A	117628083	3	1	236	1	0	0	0	0	1	0	0	0	5765	652	23	3	1755	3	FBXO21	12	117628083	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	6538896	117628083	16223812	391	43029											
NOS1	4842	broad.mit.edu	37	chr12	117662875	117662875	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagcttcggaaaggggcaaTgccggtgcctggtccaacga	10	6	15	10	3	0	0	0	0	0	0	2	3	1	1	3	5	4	2	3	5	4	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:117662875T>C	uc001twm.1	-	25	4458	c.3772A>G	c.(3772-3774)ATT>GTT	p.I1258V		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1258	NADP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AAAGGGGCAATGCCGGTGCCT	0.602													86	133					0	0	0	0	C	117662875	C	C	117662875	3	2	236	1	0	0	0	0	1	0	0	0	10595	1464	51	5	552	5	NOS1	12	117662875	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	34792	117662875	16189020	392	43030											
CLIP1	6249	broad.mit.edu	37	chr12	122825885	122825885	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtctccagtttggacttccaTagagctatcacatctgagtt	9	14	8	10	0	3	2	1	1	2	1	5	3	4	3	2	1	1	3	2	1	2	5	rs150031777		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:122825885T>A	uc001ucg.1	-	10	1972	c.1866A>T	c.(1864-1866)CTA>CTT	p.L622L	CLIP1_uc001uch.1_Silent_p.L611L|CLIP1_uc001uci.1_Silent_p.L576L|CLIP1_uc001ucj.1_Silent_p.L312L|CLIP1_uc009zxo.1_Silent_p.L178L	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	622	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TGGACTTCCATAGAGCTATCA	0.488													76	105					0	0	0	0	A	122825885	A	A	122825885	2	1	236	1	0	0	0	0	0	0	0	1	3547	1393	49	5		5	CLIP1	12	122825885	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	5163010	122825885	11026010	393	43031											
TMEM132B	114795	broad.mit.edu	37	chr12	126004094	126004094	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggtggagtacccgattgagGactccatgagtgagctggtc	9	9	15	8	1	0	3	0	3	0	0	2	6	1	5	2	4	2	2	2	4	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:126004094G>T	uc001uhe.1	+	4	1209	c.1201G>T	c.(1201-1203)GAC>TAC	p.D401Y		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	401	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCCGATTGAGGACTCCATGAG	0.532													15	98					2.31682e-05	3.57162e-05	1	0	T	126004094	T	T	126004094	3	4	236	1	0	0	0	0	1	0	0	0	16112	1174	41	2	1215	2	TMEM132B	12	126004094	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3178209	126004094	7847801	394	43032											
EP400	57634	broad.mit.edu	37	chr12	132491392	132491392	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtaaaacagtgcagatcattGctttttttgcccacctagct	10	14	7	10	0	1	1	1	0	0	1	1	1	1	1	2	0	5	4	2	0	3	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr12:132491392G>A	uc001ujn.2	+	14	3309	c.3274G>A	c.(3274-3276)GCT>ACT	p.A1092T	EP400_uc001ujl.2_Missense_Mutation_p.A1091T|EP400_uc001ujm.2_Missense_Mutation_p.A1092T	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1128	Interactions with RUVBL1 and RUVBL2.|Helicase ATP-binding.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GCAGATCATTGCTTTTTTTGC	0.428													24	36					0	0	0	0	A	132491392	A	A	132491392	3	1	236	1	0	0	0	0	1	0	0	0	5173	1319	46	4	3325	4	EP400	12	132491392	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	6487298	132491392	1360503	395	43033											
CENPJ	55835	broad.mit.edu	37	chr13	25479525	25479525	+	Frame_Shift_Del	DEL	C	-	-																															tgtttaacttgagttcatttCccaagtgtgaatctgacttt																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr13:25479525delC	uc001upt.3	-	7	2904	c.2651delG	c.(2650-2652)GGAfs	p.G884fs	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA|CENPJ_uc001upu.2_5'Flank	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	884					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		GAGTTCATTTCCCAAGTGTGA	0.373													---	---	---								-	25479525	-	-	25479525	7	5	236	1	0	1	0	1	0	0	0	0	3249	855	30	0	1409	0	CENPJ	13	25479525	Frame_Shift_Del	DEL	C	TCGA-CV-7245-01A-11D-2012-08		25479525	89690353	396	43034											
ELF1	1997	broad.mit.edu	37	chr13	41515109	41515109	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcctgcatggtactggttcTagctgcttctccctctggga	5	14	10	12	0	3	0	0	0	3	0	5	1	4	1	2	3	4	5	2	3	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr13:41515109T>C	uc001uxs.2	-	8	1577	c.1204A>G	c.(1204-1206)AGA>GGA	p.R402G	ELF1_uc010tfc.1_Missense_Mutation_p.R378G|ELF1_uc010acd.2_Missense_Mutation_p.R295G	NM_172373	NP_758961	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription	402					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		GTACTGGTTCTAGCTGCTTCT	0.468													60	24					0	0	0	0	C	41515109	C	C	41515109	3	2	236	1	0	0	0	0	1	0	0	0	5077	1530	53	5	663	5	ELF1	13	41515109	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	16035584	41515109	73654769	397	43035											
GTF2F2	2963	broad.mit.edu	37	chr13	45725938	45725938	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagtgttggaggacagacAttaacagtatttactgagag	15	10	11	5	0	0	2	0	1	0	2	0	5	0	4	0	2	2	2	0	2	4	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr13:45725938A>G	uc001uzw.2	+	4	436	c.276A>G	c.(274-276)ACA>ACG	p.T92T	GTF2F2_uc001uzv.2_Silent_p.T92T	NM_004128	NP_004119	P13984	T2FB_HUMAN	general transcription factor IIF, polypeptide 2,	92					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	microtubule cytoskeleton|transcription factor TFIIF complex	ATP binding|ATP-dependent helicase activity|DNA binding|protein binding				0		Lung NSC(96;0.00115)|Prostate(109;0.00578)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000647)		GAGGACAGACATTAACAGTAT	0.373													58	20					0	0	0	0	G	45725938	G	G	45725938	2	3	236	1	0	0	0	0	0	0	0	1	6898	204	8	5		5	GTF2F2	13	45725938	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	4210829	45725938	69443940	398	43036											
PCDH20	64881	broad.mit.edu	37	chr13	61987508	61987508	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcgataggtctgtaccccatTaatgcctacatctgggtcca	9	11	9	12	1	2	0	0	0	2	0	3	1	3	0	4	2	3	1	4	2	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr13:61987508T>C	uc001vid.3	-	2	1088	c.724A>G	c.(724-726)AAT>GAT	p.N242D	PCDH20_uc010thj.1_Missense_Mutation_p.N242D	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	215	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TGTACCCCATTAATGCCTACA	0.532													50	45					0	0	0	0	C	61987508	C	C	61987508	3	2	236	1	0	0	0	0	1	0	0	0	11569	1754	61	5	2135	5	PCDH20	13	61987508	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	16261570	61987508	53182370	399	43037											
TM9SF2	9375	broad.mit.edu	37	chr13	100193874	100193874	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtagctatgattatgttaCggacactgcacaaagatatt	13	13	9	6	1	0	2	0	1	0	1	0	3	0	3	0	2	3	4	0	2	6	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr13:100193874C>A	uc001voj.1	+	9	1103	c.970C>A	c.(970-972)CGG>AGG	p.R324R	TM9SF2_uc010afz.1_Silent_p.R159R	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	324	Cytoplasmic (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					GATTATGTTACGGACACTGCA	0.358													24	45					1.1804e-14	2.2079e-14	1	0	A	100193874	A	A	100193874	2	1	236	1	0	0	0	0	0	0	0	1	16044	527	19	3		3	TM9SF2	13	100193874	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	38206366	100193874	14976004	400	43038											
OR4L1	122742	broad.mit.edu	37	chr14	20528889	20528889	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcagtgtaccaaaaaaatCatcacatgggctctccaagg	14	8	9	10	0	4	0	3	0	1	0	5	0	4	0	2	3	1	2	2	3	5	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:20528889C>T	uc001vwn.1	+	1	686	c.686C>T	c.(685-687)TCA>TTA	p.S229L		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		CCAAAAAAATCATCACATGGG	0.438													77	78					0	0	0	0	T	20528889	T	T	20528889	3	4	236	1	0	0	0	0	1	0	0	0	11128	838	29	2	688	2	OR4L1	14	20528889	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08		20528889	86820651	401	43039											
TEP1	7011	broad.mit.edu	37	chr14	20871907	20871907	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggggtggccggcgggggTgtctcttggcccggtgcttc	1	9	20	11	4	1	0	0	0	1	0	3	0	1	0	2	8	2	1	2	8	0	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:20871907T>A	uc001vxe.2	-	6	1209	c.1169A>T	c.(1168-1170)CAC>CTC	p.H390L	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Intron	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	390	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CCGGCGGGGGTGTCTCTTGGC	0.627													37	79					0	0	0	0	A	20871907	A	A	20871907	3	1	236	1	0	0	0	0	1	0	0	0	15825	1696	59	5	6914	5	TEP1	14	20871907	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	343018	20871907	86477633	402	43040											
RNASE4	6038	broad.mit.edu	37	chr14	21167532	21167532	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcacctctaagatactgaTggctctgcagaggacccatt	11	9	10	11	0	2	3	0	1	2	2	2	4	2	4	2	3	2	3	2	3	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:21167532T>A	uc001vxy.3	+	2	565	c.2T>A	c.(1-3)ATG>AAG	p.M1K	RNASE4_uc001vxx.3_RNA|RNASE4_uc001vya.2_Missense_Mutation_p.M1K	NM_002937	NP_002928	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4 precursor	1					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)	1	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		AAGATACTGATGGCTCTGCAG	0.532													32	100					0	0	0	0	A	21167532	A	A	21167532	3	1	236	1	0	0	0	0	1	0	0	0	13471	1464	51	5	4	5	RNASE4	14	21167532	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	295625	21167532	86182008	403	43041											
TOX4	9878	broad.mit.edu	37	chr14	21961060	21961062	+	In_Frame_Del	DEL	GCT	-	-																															cagtgttgcaggcagcagcaGctgctgctgctgctgcttct																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	bdc58b10-1756-45bf-a34f-fa4095429476	g.chr14:21961060_21961062delGCT	uc001waz.2	+	7	1388_1390	c.1285_1287delGCT	c.(1285-1287)GCTdel	p.A434del	TOX4_uc001way.2_In_Frame_Del_p.A304del|TOX4_uc001wba.2_Splice_Site|TOX4_uc010tlu.1_In_Frame_Del_p.A411del|TOX4_uc010tlv.1_In_Frame_Del_p.A304del	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	434	Gln/Pro-rich.|Poly-Ala.					chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		GGCAGCAGCAGCTGCTGCTGCTG	0.581													---	---	---								-	21961062	-	-	21961060	7	5	236	1	0	1	0	1	0	0	0	0	16447	971	34	0	1311	0	TOX4	14	21961060	In_Frame_Del	DEL	GCT	TCGA-CV-7245-01A-11D-2012-08	793528	21961060	85388480	404	43042											
PSMB11	122706	broad.mit.edu	37	chr14	23512042	23512042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcacccaggaagcctacgCcctggctcgctgcgccgtgg	6	5	14	16	4	0	0	0	0	0	0	1	2	0	1	4	3	4	3	4	3	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:23512042C>T	uc010ake.1	+	1	667	c.608C>T	c.(607-609)GCC>GTC	p.A203V		NM_001099780	NP_001093250	A5LHX3	PSB11_HUMAN	proteasome beta 11 subunit precursor	203					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)		GAAGCCTACGCCCTGGCTCGC	0.627													28	36					0	0	0	0	T	23512042	T	T	23512042	3	4	236	1	0	0	0	0	1	0	0	0	12738	739	26	4	610	4	PSMB11	14	23512042	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1550982	23512042	83837498	405	43043											
MYH6	4624	broad.mit.edu	37	chr14	23862578	23862578	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgctgctccagcttgacCttagacttggacaggctgtt	7	12	10	12	0	0	2	0	1	0	1	1	3	1	3	3	2	3	5	3	2	1	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:23862578C>A	uc001wjv.2	-	23	3145	c.3078G>T	c.(3076-3078)AAG>AAT	p.K1026N		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1026	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCAGCTTGACCTTAGACTTGG	0.517													36	145					2.20474e-14	4.11607e-14	1	0	A	23862578	A	A	23862578	3	1	236	1	0	0	0	0	1	0	0	0	10091	680	24	4	2809	4	MYH6	14	23862578	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	350536	23862578	83486962	406	43044											
DHRS2	10202	broad.mit.edu	37	chr14	24108190	24108190	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctggctaaccgggtagcCgtggtcacggggtccaccag	6	7	15	13	3	1	0	1	0	0	0	3	0	3	0	5	5	2	2	5	5	2	2	rs146713514	byFrequency	TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:24108190C>A	uc001wkt.3	+	2	564	c.117C>A	c.(115-117)GCC>GCA	p.A39A	DHRS2_uc010aku.1_Silent_p.A39A|DHRS2_uc001wku.3_Silent_p.A39A|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Silent_p.A39A	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	17					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		ACCGGGTAGCCGTGGTCACGG	0.612													50	84					4.25531e-23	8.56295e-23	1	0	A	24108190	A	A	24108190	2	1	236	1	0	0	0	0	0	0	0	1	4512	639	23	3		3	DHRS2	14	24108190	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	245612	24108190	83241350	407	43045											
REC8	9985	broad.mit.edu	37	chr14	24641797	24641797	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgtgcttcagcgccacacCggctgctttgccaccatctg	7	9	9	16	3	2	0	1	0	1	0	2	0	2	0	4	1	5	3	4	1	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:24641797C>T	uc001wmr.2	+	2	463	c.36C>T	c.(34-36)ACC>ACT	p.T12T	REC8_uc001wms.2_Silent_p.T12T	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	12					mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		AGCGCCACACCGGCTGCTTTG	0.612													8	44					0	0	0	0	T	24641797	T	T	24641797	2	4	236	1	0	0	0	0	0	0	0	1	13264	639	23	1		1	REC8	14	24641797	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	533607	24641797	82707743	408	43046											
RALGAPA1	253959	broad.mit.edu	37	chr14	36217975	36217975	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttctgtagttctgtctgttTtatcagcattatcatttttg	6	22	7	6	0	5	0	2	0	3	0	5	0	5	0	0	0	1	5	0	0	3	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:36217975T>C	uc001wti.2	-	10	1458	c.1067A>G	c.(1066-1068)AAA>AGA	p.K356R	RALGAPA1_uc001wtj.2_Missense_Mutation_p.K356R|RALGAPA1_uc010tpv.1_Missense_Mutation_p.K356R|RALGAPA1_uc010tpw.1_Missense_Mutation_p.K356R|RALGAPA1_uc001wtk.1_Missense_Mutation_p.K207R	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	356					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TCTGTCTGTTTTATCAGCATT	0.353													16	84					0	0	0	0	C	36217975	C	C	36217975	3	2	236	1	0	0	0	0	1	0	0	0	13078	1841	64	5	5320	5	RALGAPA1	14	36217975	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	11576178	36217975	71131565	409	43047											
MDGA2	161357	broad.mit.edu	37	chr14	47504488	47504488	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggtgatttttcctgtggAacagtcagattgggtggaac	10	13	13	5	0	1	2	1	1	0	1	2	4	2	4	1	4	2	0	1	4	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:47504488A>T	uc001wwj.3	-	8	1534	c.1338T>A	c.(1336-1338)GTT>GTA	p.V446V	MDGA2_uc001wwi.3_Silent_p.V217V|MDGA2_uc010ani.2_Intron	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	446	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TTTCCTGTGGAACAGTCAGAT	0.373													41	56					0	0	0	0	T	47504488	T	T	47504488	2	4	236	1	0	0	0	0	0	0	0	1	9460	233	9	5		5	MDGA2	14	47504488	Silent	SNP	A	TCGA-CV-7245-01A-11D-2012-08	11286513	47504488	59845052	410	43048											
SOS2	6655	broad.mit.edu	37	chr14	50596694	50596694	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttacttgaatgtggcaaaaGcactggagcaaagatgctat	14	10	10	7	0	0	2	0	1	0	1	0	3	0	3	0	2	4	4	0	2	6	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:50596694G>C	uc001wxs.3	-	21	3462	c.3364C>G	c.(3364-3366)CTT>GTT	p.L1122V	SOS2_uc010ans.2_5'UTR|SOS2_uc010tql.1_Missense_Mutation_p.L1089V	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1122					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					TGTGGCAAAAGCACTGGAGCA	0.274													6	33					0	0	0	0	C	50596694	C	C	50596694	3	2	236	1	0	0	0	0	1	0	0	0	15001	971	34	4	646	4	SOS2	14	50596694	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3092206	50596694	56752846	411	43049											
SLC35F4	341880	broad.mit.edu	37	chr14	58048102	58048102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagggagcagttcttttaaGaaagagtttcagcgtcagac	14	10	11	6	1	3	3	2	0	1	3	3	4	3	4	0	1	2	3	0	1	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:58048102G>A	uc001xdb.1	-	4	745	c.745C>T	c.(745-747)CTT>TTT	p.L249F	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.L90F	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						GTTCTTTTAAGAAAGAGTTTC	0.413													6	30					0	0	0	0	A	58048102	A	A	58048102	3	1	236	1	0	0	0	0	1	0	0	0	14655	942	33	2	840	2	SLC35F4	14	58048102	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	7451408	58048102	49301438	412	43050											
C14orf39	317761	broad.mit.edu	37	chr14	60903645	60903645	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtattgaattttgacccTgtccaaatgaaaatggaaaa	17	11	8	5	0	0	3	0	3	0	0	1	4	1	4	2	2	0	1	2	2	8	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:60903645T>C	uc001xez.3	-	18	1792	c.1682A>G	c.(1681-1683)CAG>CGG	p.Q561R	C14orf39_uc010apo.2_Missense_Mutation_p.Q272R	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	561								p.Q561E(1)		ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		ATTTTGACCCTGTCCAAATGA	0.323													65	195					0	0	0	0	C	60903645	C	C	60903645	3	2	236	1	0	0	0	0	1	0	0	0	1778	1580	55	5	85	5	C14orf39	14	60903645	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2855543	60903645	46445895	413	43051											
TMED10	10972	broad.mit.edu	37	chr14	75614419	75614419	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgtctaggatcacgagtTggtcaggtatccgccctgtt	7	13	11	10	2	4	0	3	0	1	0	5	2	5	1	2	3	0	3	2	3	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:75614419T>G	uc001xrm.1	-	3	426	c.359A>C	c.(358-360)CAA>CCA	p.Q120P	TMED10_uc010ash.1_RNA|TMED10_uc010asg.1_RNA|TMED10_uc010tuz.1_5'UTR	NM_006827	NP_006818	P49755	TMEDA_HUMAN	transmembrane emp24 domain-containing protein 10	120	Lumenal (Potential).|GOLD.				protein transport|regulated secretory pathway|vesicle targeting, to, from or within Golgi	cis-Golgi network|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|melanosome|microsome|zymogen granule membrane	protein binding				0				BRCA - Breast invasive adenocarcinoma(234;0.0126)		GATCACGAGTTGGTCAGGTAT	0.493													55	218					0	0	0	0	G	75614419	G	G	75614419	3	3	236	1	0	0	0	0	1	0	0	0	16069	1812	63	5	312	5	TMED10	14	75614419	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	14710774	75614419	31735121	414	43052											
ANGEL1	23357	broad.mit.edu	37	chr14	77274328	77274328	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatagttccaattgaggatGtctggatggcaatgtagata	12	12	12	5	1	1	2	0	1	1	1	2	5	2	4	1	3	0	3	1	3	5	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:77274328G>A	uc001xsv.2	-	3	926	c.813C>T	c.(811-813)GAC>GAT	p.D271D	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	271										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		AATTGAGGATGTCTGGATGGC	0.498													6	54					0	0	0	0	A	77274328	A	A	77274328	2	1	236	1	0	0	0	0	0	0	0	1	608	1368	48	4		4	ANGEL1	14	77274328	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1659909	77274328	30075212	415	43053											
C14orf102	55051	broad.mit.edu	37	chr14	90769079	90769079	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttaccaaacatggcctcttCcgtgccaggcaacgcagggt	9	8	10	14	2	1	0	0	0	1	0	2	0	2	0	4	3	4	2	4	3	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:90769079C>T	uc001xyi.1	-	6	1427	c.1396G>A	c.(1396-1398)GAA>AAA	p.E466K	C14orf102_uc010atp.1_Intron|C14orf102_uc001xyj.1_Missense_Mutation_p.E235K	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	466							protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		ATGGCCTCTTCCGTGCCAGGC	0.413													8	44					0	0	0	0	T	90769079	T	T	90769079	3	4	236	1	0	0	0	0	1	0	0	0	1741	864	30	2	2134	2	C14orf102	14	90769079	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	13494751	90769079	16580461	416	43054											
KIAA1409	57578	broad.mit.edu	37	chr14	94044388	94044388	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctaaattgtttcatcctcatGtttgatcttctcctgaagca	9	17	5	10	0	4	2	2	2	2	0	6	2	5	2	2	0	1	3	2	0	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:94044388G>T	uc001ybv.1	+	15	1964	c.1881G>T	c.(1879-1881)ATG>ATT	p.M627I	KIAA1409_uc001ybs.1_Missense_Mutation_p.M627I	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	804						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TCATCCTCATGTTTGATCTTC	0.403													6	68					0.00198382	0.00292949	1	0	T	94044388	T	T	94044388	3	4	236	1	0	0	0	0	1	0	0	0	8269	1377	48	4	1939	4	KIAA1409	14	94044388	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3275309	94044388	13305152	417	43055											
KIAA1409	57578	broad.mit.edu	37	chr14	94088986	94088986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	accccacagaaagtgagaagCctgataccagtgcagaatct	15	6	9	11	0	1	4	0	2	1	3	1	5	1	4	4	0	3	1	4	0	4	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:94088986C>T	uc001ybv.1	+	28	5025	c.4942C>T	c.(4942-4944)CCT>TCT	p.P1648S	KIAA1409_uc001ybs.1_Missense_Mutation_p.P1626S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1803						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AAGTGAGAAGCCTGATACCAG	0.498													9	52					0	0	0	0	T	94088986	T	T	94088986	3	4	236	1	0	0	0	0	1	0	0	0	8269	739	26	4	4982	4	KIAA1409	14	94088986	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	44598	94088986	13260554	418	43056											
SERPINA11	256394	broad.mit.edu	37	chr14	94914815	94914815	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgaatcccaggccctccagGatcagagctgaggtgttagc	9	9	12	11	0	1	3	1	2	0	1	3	4	3	4	3	3	2	2	3	3	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:94914815G>T	uc001ydd.1	-	2	357	c.297C>A	c.(295-297)ATC>ATA	p.I99I		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	99					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		GGCCCTCCAGGATCAGAGCTG	0.622													24	142					2.89027e-11	5.07736e-11	1	0	T	94914815	T	T	94914815	2	4	236	1	0	0	0	0	0	0	0	1	14153	1164	41	2		2	SERPINA11	14	94914815	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	825829	94914815	12434725	419	43057											
SERPINA9	327657	broad.mit.edu	37	chr14	94936102	94936102	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgggggtatgcactgggggCattggccggggacacacagt	7	6	19	9	2	0	0	0	0	0	0	0	1	0	1	1	7	1	3	1	7	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:94936102C>A	uc001ydf.2	-	2	291	c.130G>T	c.(130-132)GCC>TCC	p.A44S	SERPINA9_uc001yde.2_Missense_Mutation_p.A44S|SERPINA9_uc010avc.2_Intron|SERPINA9_uc001ydg.2_Intron|SERPINA9_uc001ydh.1_Missense_Mutation_p.A44S|SERPINA9_uc001ydi.1_Intron	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	26					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GCACTGGGGGCATTGGCCGGG	0.532													15	91					4.7546e-09	8.03618e-09	1	0	A	94936102	A	A	94936102	3	1	236	1	0	0	0	0	1	0	0	0	14160	710	25	4	1193	4	SERPINA9	14	94936102	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	21287	94936102	12413438	420	43058											
CLMN	79789	broad.mit.edu	37	chr14	95670290	95670290	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttttcctcagcaacctcaaCtgccaagacatgtccatcct	10	11	4	16	0	2	1	2	0	0	1	5	1	5	1	5	0	4	1	5	0	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:95670290C>G	uc001yef.2	-	9	1512	c.1396G>C	c.(1396-1398)GTT>CTT	p.V466L		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	466						integral to membrane	actin binding				0				Epithelial(152;0.193)		GCAACCTCAACTGCCAAGACA	0.488													13	74					0	0	0	0	G	95670290	G	G	95670290	3	3	236	1	0	0	0	0	1	0	0	0	3557	565	20	4	1632	4	CLMN	14	95670290	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	734188	95670290	11679250	421	43059											
BCL11B	64919	broad.mit.edu	37	chr14	99641175	99641175	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcttgcgcgggaagagcccGgggaagggctcggtgcctgg	5	5	21	10	4	0	1	0	0	0	1	1	3	0	3	2	7	3	2	2	7	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:99641175G>A	uc001yga.2	-	4	2265	c.1998C>T	c.(1996-1998)CCC>CCT	p.P666P	BCL11B_uc001ygb.2_Silent_p.P595P	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	666						nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GGAAGAGCCCGGGGAAGGGCT	0.478			T	TLX3	T-ALL								3	11					0	0	0	0	A	99641175	A	A	99641175	2	1	236	1	0	0	0	0	0	0	0	1	1366	1103	39	1		1	BCL11B	14	99641175	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3970885	99641175	7708365	422	43060											
DYNC1H1	1778	broad.mit.edu	37	chr14	102500485	102500485	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagatgcgtcagaacttgtTcactacctggtcccatcacc	9	10	8	14	1	3	2	3	0	0	2	4	2	4	2	3	1	3	2	3	1	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:102500485T>G	uc001yks.2	+	55	10750	c.10586T>G	c.(10585-10587)TTC>TGC	p.F3529C		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3529					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CAGAACTTGTTCACTACCTGG	0.507													41	219					0	0	0	0	G	102500485	G	G	102500485	3	3	236	1	0	0	0	0	1	0	0	0	4863	1783	62	5	10804	5	DYNC1H1	14	102500485	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2859310	102500485	4849055	423	43061											
CDC42BPB	9578	broad.mit.edu	37	chr14	103416154	103416154	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctgggtggattttccttCaggcagatcatacaggaaga	11	10	13	7	0	2	2	2	0	0	2	3	4	3	4	1	5	1	2	1	5	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:103416154C>A	uc001ymi.1	-	26	3629	c.3397G>T	c.(3397-3399)GAA>TAA	p.E1133*	CDC42BPB_uc001ymj.1_Nonsense_Mutation_p.E235*	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1133	PH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GATTTTCCTTCAGGCAGATCA	0.527													52	90					8.78508e-14	1.61553e-13	1	0	A	103416154	A	A	103416154	4	1	236	1	0	0	0	0	0	1	0	0	3088	835	29	2	1786	2	CDC42BPB	14	103416154	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	915669	103416154	3933386	424	43062											
GPR132	29933	broad.mit.edu	37	chr14	105521755	105521755	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttcagtagcattgggcaCattcacattcttctgcaacc	9	15	6	11	0	4	0	2	0	2	0	4	0	4	0	1	1	3	4	1	1	2	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr14:105521755C>A	uc001yqd.2	-	3	902	c.3G>T	c.(1-3)ATG>ATT	p.M1I	GPR132_uc001yqc.2_5'UTR|GPR132_uc001yqe.2_Intron|GPR132_uc010axe.1_RNA	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	1	Extracellular (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		gcattgggcacattcacattc	0.015													51	96					9.90819e-18	1.93436e-17	1	0	A	105521755	A	A	105521755	3	1	236	1	0	0	0	0	1	0	0	0	6680	478	17	4	1147	4	GPR132	14	105521755	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2105601	105521755	1827785	425	43063											
OR4N4	283694	broad.mit.edu	37	chr15	22383249	22383249	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgctatcttcatctacatGtgccctttcagggccttacc	6	14	6	15	0	4	0	2	0	2	0	4	0	4	0	4	1	4	1	4	1	3	5	rs112081824	byFrequency	TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:22383249G>T	uc001yuc.1	+	7	1758	c.777G>T	c.(775-777)ATG>ATT	p.M259I	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Missense_Mutation_p.M259I	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCATCTACATGTGCCCTTTCA	0.453													41	208					3.43241e-23	6.93546e-23	1	0	T	22383249	T	T	22383249	3	4	236	1	0	0	0	0	1	0	0	0	11132	1377	48	4	779	4	OR4N4	15	22383249	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08		22383249	80148143	426	43064											
MAGEL2	54551	broad.mit.edu	37	chr15	23890840	23890840	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggcggtgcctgccaggaagGctggagcggcagtgtgggca	7	5	20	9	2	0	0	0	0	0	0	0	2	0	2	2	7	3	3	2	7	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:23890840G>A	uc001ywj.3	-	1	336	c.241C>T	c.(241-243)CCT>TCT	p.P81S		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TGCCAGGAAGGCTGGAGCGGC	0.667													6	9					0	0	0	0	A	23890840	A	A	23890840	3	1	236	1	0	0	0	0	1	0	0	0	9242	1203	42	4	1703	4	MAGEL2	15	23890840	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1507591	23890840	78640552	427	43065											
C15orf2	23742	broad.mit.edu	37	chr15	24922500	24922500	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcagcgcctctcacttctGaccccccaacacctcctagc	8	7	6	20	1	2	1	1	1	2	0	4	2	3	1	6	0	4	1	6	0	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:24922500G>T	uc001ywo.2	+	1	1960	c.1486G>T	c.(1486-1488)GAC>TAC	p.D496Y		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	496	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TCTCACTTCTGACCCCCCAAC	0.522													43	191					9.73076e-26	1.97839e-25	1	0	T	24922500	T	T	24922500	3	4	236	1	0	0	0	0	1	0	0	0	1790	1290	45	2	1488	2	C15orf2	15	24922500	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1031660	24922500	77608892	428	43066											
ATP10A	57194	broad.mit.edu	37	chr15	26026179	26026179	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacttacaagctccgagaagCcgcggaccacctgccgccgc	9	4	10	18	5	0	1	0	0	0	1	1	3	1	2	6	1	4	1	6	1	3	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:26026179C>G	uc010ayu.2	-	2	747	c.641G>C	c.(640-642)GGC>GCC	p.G214A		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	214	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CTCCGAGAAGCCGCGGACCAC	0.612													13	68					0	0	0	0	G	26026179	G	G	26026179	3	3	236	1	0	0	0	0	1	0	0	0	1118	739	26	4	3938	4	ATP10A	15	26026179	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1103679	26026179	76505213	429	43067											
SPTBN5	51332	broad.mit.edu	37	chr15	42167082	42167082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttccaggatggccggggagGcggccatgccatgggccatg	6	6	17	12	2	0	0	0	0	0	0	1	2	1	2	5	7	1	0	5	7	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:42167082G>A	uc001zos.2	-	23	4688	c.4355C>T	c.(4354-4356)GCC>GTC	p.A1452V		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1487	Spectrin 11.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GGCCGGGGAGGCGGCCATGCC	0.637													8	44					0	0	0	0	A	42167082	A	A	42167082	3	1	236	1	0	0	0	0	1	0	0	0	15188	1203	42	4	6748	4	SPTBN5	15	42167082	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	16140903	42167082	60364310	430	43068											
EPB42	2038	broad.mit.edu	37	chr15	43507460	43507460	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaccactgcactccaccacTttcggtcccccagactggaa	9	7	6	19	1	0	1	0	0	0	1	3	2	2	2	6	2	1	1	6	2	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:43507460T>C	uc001zra.3	-	3	563	c.263A>G	c.(262-264)AAG>AGG	p.K88R	EPB42_uc010bde.2_5'UTR|EPB42_uc001zrb.3_Missense_Mutation_p.K118R|EPB42_uc010udm.1_Intron	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	88					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		ACTCCACCACTTTCGGTCCCC	0.562													29	88					0	0	0	0	C	43507460	C	C	43507460	3	2	236	1	0	0	0	0	1	0	0	0	5182	1609	56	5	1856	5	EPB42	15	43507460	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	1340378	43507460	59023932	431	43069											
GATM	2628	broad.mit.edu	37	chr15	45660362	45660362	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgataattgacctgtacgctCggtactcaaagaagcgtgaa	13	10	10	8	3	1	4	1	3	0	1	2	4	1	4	1	1	3	3	1	1	6	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:45660362C>T	uc001zvc.2	-	4	910	c.581G>A	c.(580-582)CGA>CAA	p.R194Q	GATM_uc001zvb.2_Missense_Mutation_p.R65Q|GATM_uc010uev.1_Missense_Mutation_p.R247Q	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	194					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	CCTGTACGCTCGGTACTCAAA	0.493													11	43					0	0	0	0	T	45660362	T	T	45660362	3	4	236	1	0	0	0	0	1	0	0	0	6298	884	31	1	714	1	GATM	15	45660362	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2152902	45660362	56871030	432	43070											
PRTG	283659	broad.mit.edu	37	chr15	55965629	55965629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tactgatgactctcccagccCcactctggtggcagcagtaa	9	9	9	14	0	2	2	0	2	2	0	3	2	2	2	3	2	3	3	3	2	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:55965629C>T	uc002adg.2	-	10	1840	c.1792G>A	c.(1792-1794)GGG>AGG	p.G598R	PRTG_uc002adh.2_Missense_Mutation_p.G100R	NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	598	Fibronectin type-III 2.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TCTCCCAGCCCCACTCTGGTG	0.488													18	70					0	0	0	0	T	55965629	T	T	55965629	3	4	236	1	0	0	0	0	1	0	0	0	12700	623	22	4	1704	4	PRTG	15	55965629	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	10305267	55965629	46565763	433	43071											
AQP9	366	broad.mit.edu	37	chr15	58458911	58458911	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgcccaagctattctcagtCgaggacgttttggaggggtc	7	12	13	9	2	1	0	1	0	1	0	4	3	1	2	1	4	2	2	1	4	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:58458911C>T	uc002aez.2	+	2	508	c.151C>T	c.(151-153)CGA>TGA	p.R51*	ALDH1A2_uc010ugw.1_Intron|AQP9_uc010ugx.1_5'UTR	NM_020980	NP_066190	O43315	AQP9_HUMAN	aquaporin 9	51	Extracellular (Potential).				cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			ovary(1)	1				GBM - Glioblastoma multiforme(80;0.16)		TATTCTCAGTCGAGGACGTTT	0.468													51	186					0	0	0	0	T	58458911	T	T	58458911	4	4	236	1	0	0	0	0	0	1	0	0	833	876	31	1	157	1	AQP9	15	58458911	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2493282	58458911	44072481	434	43072											
CA12	771	broad.mit.edu	37	chr15	63632630	63632630	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaatgttgaatcccgggaCgaatgcttcctggcctagag	9	11	11	10	2	1	2	1	1	0	1	3	4	3	3	3	2	1	2	3	2	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:63632630C>T	uc002amc.2	-	7	760	c.604G>A	c.(604-606)GTC>ATC	p.V202I	CA12_uc002amd.2_Missense_Mutation_p.V202I|CA12_uc002ame.2_Missense_Mutation_p.V142I	NM_001218	NP_001209	O43570	CAH12_HUMAN	carbonic anhydrase XII isoform 1 precursor	202	Extracellular (Potential).				one-carbon metabolic process	integral to membrane	carbonate dehydratase activity|zinc ion binding			ovary(1)	1					Acetazolamide(DB00819)	AATCCCGGGACGAATGCTTCC	0.562													12	49					0	0	0	0	T	63632630	T	T	63632630	3	4	236	1	0	0	0	0	1	0	0	0	2525	536	19	1	480	1	CA12	15	63632630	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5173719	63632630	38898762	435	43073											
IQCH	64799	broad.mit.edu	37	chr15	67757586	67757586	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctggaagtgccccgctttgTtccaaaggaaaggaagaaaa	14	7	11	9	1	0	1	0	0	0	1	1	4	1	4	4	3	1	2	4	3	6	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:67757586T>G	uc002aqo.1	+	17	2674	c.2627T>G	c.(2626-2628)GTT>GGT	p.V876G	IQCH_uc002aqq.1_Missense_Mutation_p.V533G|IQCH_uc002aqp.1_Missense_Mutation_p.V537G|uc002aqr.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	876										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		CCCCGCTTTGTTCCAAAGGAA	0.517													45	48					0	0	0	0	G	67757586	G	G	67757586	3	3	236	1	0	0	0	0	1	0	0	0	7850	1725	60	5	2821	5	IQCH	15	67757586	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	4124956	67757586	34773806	436	43074											
FAM108C1	58489	broad.mit.edu	37	chr15	80988172	80988172	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgccctccagccgctacacGctgctcttctcgcacggcaa	6	7	9	19	5	2	0	0	0	2	0	4	0	3	0	3	1	3	5	3	1	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:80988172G>T	uc002bfu.2	+	1	521	c.402G>T	c.(400-402)ACG>ACT	p.T134T	FAM108C1_uc002bft.2_Silent_p.T127T	NM_021214	NP_067037	Q6PCB6	F108C_HUMAN	hypothetical protein LOC58489	134							hydrolase activity				0						GCCGCTACACGCTGCTCTTCT	0.652													5	9					0.000602214	0.000896022	1	0	T	80988172	T	T	80988172	2	4	236	1	0	0	0	0	0	0	0	1	5421	1074	38	3		3	FAM108C1	15	80988172	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	13230586	80988172	21543220	437	43075											
ACAN	176	broad.mit.edu	37	chr15	89403596	89403596	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaggagccctgtggagctgGgacctgcaaggagacagagg	11	4	18	8	0	0	3	0	0	0	3	0	7	0	6	2	5	3	2	2	5	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:89403596G>T	uc010upo.1	+	13	7246	c.6872G>T	c.(6871-6873)GGG>GTG	p.G2291V	ACAN_uc010upp.1_Intron|ACAN_uc002bna.2_Intron	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2291					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGTGGAGCTGGGACCTGCAAG	0.617													20	18					1.00905e-13	1.85212e-13	1	0	T	89403596	T	T	89403596	3	4	236	1	0	0	0	0	1	0	0	0	117	1232	43	4	6918	4	ACAN	15	89403596	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	8415424	89403596	13127796	438	43076											
C15orf58	390637	broad.mit.edu	37	chr15	90784840	90784840	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gactgcccgtggagcaggcgCcaagcgagcccctggaccct	7	4	14	16	3	0	0	0	0	0	0	0	4	0	2	5	3	4	1	5	3	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:90784840C>A	uc002bpc.2	+	4	879	c.700C>A	c.(700-702)CCA>ACA	p.P234T		NM_001013657	NP_001013679	Q6ZNW5	VTC2_HUMAN	hypothetical protein LOC390637	234					glucose metabolic process	cytoplasm	GDP-D-glucose phosphorylase activity				0						GGAGCAGGCGCCAAGCGAGCC	0.632													20	64					2.37509e-13	4.34328e-13	1	0	A	90784840	A	A	90784840	3	1	236	1	0	0	0	0	1	0	0	0	1812	739	26	4	702	4	C15orf58	15	90784840	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1381244	90784840	11746552	439	43077											
ARRDC4	91947	broad.mit.edu	37	chr15	98513117	98513117	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttttggcttattaggtatAcattcacattcctggtgcta	8	19	7	7	0	1	0	1	0	0	0	2	0	2	0	1	3	2	3	1	3	5	10			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr15:98513117A>G	uc010bom.2	+	6	1046	c.887A>G	c.(886-888)TAC>TGC	p.Y296C	ARRDC4_uc002bui.3_Missense_Mutation_p.Y209C	NM_183376	NP_899232	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	296					signal transduction						0	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			TATTAGGTATACATTCACATT	0.353													10	37					0	0	0	0	G	98513117	G	G	98513117	3	3	236	1	0	0	0	0	1	0	0	0	987	391	14	5	909	5	ARRDC4	15	98513117	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	7728277	98513117	4018275	440	43078											
WDR24	84219	broad.mit.edu	37	chr16	737322	737322	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcacacgggccaccgaggCgatggtctgcacacagtgca	9	6	12	14	3	2	0	1	0	1	0	2	2	2	0	2	3	2	2	2	3	0	1	rs145838196	byFrequency	TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:737322C>T	uc002ciz.1	-	3	1514	c.754G>A	c.(754-756)GCC>ACC	p.A252T	JMJD8_uc002ciw.1_5'Flank|JMJD8_uc002cix.1_5'Flank|JMJD8_uc002ciy.1_5'Flank	NM_032259	NP_115635	Q96S15	WDR24_HUMAN	WD repeat domain 24	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(1)|central_nervous_system(1)	2		Hepatocellular(780;0.0218)				GCCACCGAGGCGATGGTCTGC	0.637													21	59					0	0	0	0	T	737322	T	T	737322	3	4	236	1	0	0	0	0	1	0	0	0	17349	768	27	1	1646	1	WDR24	16	737322	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08		737322	89617431	441	43079											
SOX8	30812	broad.mit.edu	37	chr16	1035270	1035270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaccagtacccctgcttcCactcgccgcgccggccctac	5	8	7	21	4	1	0	0	0	1	0	3	0	2	0	7	1	4	2	7	1	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:1035270C>T	uc002ckn.2	+	3	1340	c.1225C>T	c.(1225-1227)CAC>TAC	p.H409Y		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	409					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				CCCCTGCTTCCACTCGCCGCG	0.692													10	40					0	0	0	0	T	1035270	T	T	1035270	3	4	236	1	0	0	0	0	1	0	0	0	15021	594	21	4	1235	4	SOX8	16	1035270	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	297948	1035270	89319483	442	43080											
GLYR1	84656	broad.mit.edu	37	chr16	4861228	4861228	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accgcatcacccagcgcaatGgctaagcggagatccttctg	10	7	10	14	3	2	1	1	0	1	1	3	2	3	1	3	2	2	3	3	2	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:4861228G>T	uc002cxx.3	-	15	1567	c.1530C>A	c.(1528-1530)GCC>GCA	p.A510A	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Silent_p.A424A|GLYR1_uc002cya.2_Silent_p.A504A|GLYR1_uc010uxv.1_Silent_p.A429A	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	510					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						CCAGCGCAATGGCTAAGCGGA	0.493													35	119					4.62619e-21	9.17761e-21	1	0	T	4861228	T	T	4861228	2	4	236	1	0	0	0	0	0	0	0	1	6520	1335	47	4		4	GLYR1	16	4861228	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3825958	4861228	85493525	443	43081											
GRIN2A	2903	broad.mit.edu	37	chr16	9858285	9858285	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggagtgggtcctattctctGctgttgcctcatccctctgg	3	14	12	12	0	3	0	1	0	2	0	6	1	5	1	3	3	2	2	3	3	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:9858285G>T	uc002czo.3	-	13	3664	c.3116C>A	c.(3115-3117)GCA>GAA	p.A1039E	GRIN2A_uc010uym.1_Missense_Mutation_p.A1039E|GRIN2A_uc010uyn.1_Missense_Mutation_p.A882E|GRIN2A_uc002czr.3_Missense_Mutation_p.A1039E	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1039	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCTATTCTCTGCTGTTGCCTC	0.537													88	101					4.92795e-40	1.03624e-39	1	0	T	9858285	T	T	9858285	3	4	236	1	0	0	0	0	1	0	0	0	6818	1319	46	4	1282	4	GRIN2A	16	9858285	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4997057	9858285	80496468	444	43082											
TMC5	79838	broad.mit.edu	37	chr16	19488760	19488760	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaatgttgtctcttctgtttAgaaacatctttttgaaaata	13	18	5	5	0	3	2	0	1	3	1	4	2	3	2	0	0	1	2	0	0	6	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:19488760A>T	uc002dgc.3	+	13	2840	c.2091_splice	c.e13-2	p.R697_splice	TMC5_uc010vaq.1_Splice_Site_p.R645_splice|TMC5_uc002dgb.3_Splice_Site_p.R697_splice|TMC5_uc010var.1_Splice_Site_p.R697_splice|TMC5_uc002dgd.1_Splice_Site_p.R451_splice|TMC5_uc002dge.3_Splice_Site_p.R451_splice|TMC5_uc002dgf.3_Splice_Site_p.R380_splice|TMC5_uc002dgg.3_Splice_Site_p.R338_splice	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a							integral to membrane				skin(1)	1						TCTTCTGTTTAGAAACATCTT	0.249													15	48					0	0	0	0	T	19488760	T	T	19488760	5	4	236	1	0	0	0	0	0	0	1	0	16054	434	15	5	2445	5	TMC5	16	19488760	Splice_Site	SNP	A	TCGA-CV-7245-01A-11D-2012-08	9630475	19488760	70865993	445	43083											
SCNN1G	6340	broad.mit.edu	37	chr16	23203779	23203779	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacatcatggcacaggtgcCtctggagaagaaaatcaaca	16	6	10	9	0	3	2	2	0	1	2	3	4	3	2	1	3	3	1	1	3	5	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:23203779C>A	uc002dlm.1	+	4	864	c.725C>A	c.(724-726)CCT>CAT	p.P242H		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	242	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	GCACAGGTGCCTCTGGAGAAG	0.498													19	61					7.07596e-05	0.00010773	1	0	A	23203779	A	A	23203779	3	1	236	1	0	0	0	0	1	0	0	0	13995	681	24	4	735	4	SCNN1G	16	23203779	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3715019	23203779	67150974	446	43084											
STX4	6810	broad.mit.edu	37	chr16	31049253	31049253	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcttcatctttagcatgggGtcctgtcccagcaattcgtg	6	15	9	11	1	3	0	1	0	2	0	6	0	5	0	2	2	2	2	2	2	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:31049253G>C	uc002eal.2	+	6	609	c.385G>C	c.(385-387)GTC>CTC	p.V129L	STX4_uc002eak.2_Missense_Mutation_p.V127L|STX4_uc002eam.2_Missense_Mutation_p.V51L	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	129	Cytoplasmic (Potential).|Potential.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						TTAGCATGGGGTCCTGTCCCA	0.537													21	83					0	0	0	0	C	31049253	C	C	31049253	3	2	236	1	0	0	0	0	1	0	0	0	15413	1261	44	4	407	4	STX4	16	31049253	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	7845474	31049253	59305500	447	43085											
HEATR3	55027	broad.mit.edu	37	chr16	50118116	50118116	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttatggagaattccttcAgtgagtgcgggggacagctg	9	11	14	7	1	1	2	1	1	0	1	2	4	2	3	1	3	2	1	1	3	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:50118116A>G	uc002efw.2	+	9	1366	c.1204A>G	c.(1204-1206)AGT>GGT	p.S402G	HEATR3_uc002efx.2_Missense_Mutation_p.S316G	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	402							binding			ovary(1)|skin(1)	2						GAATTCCTTCAGTGAGTGCGG	0.502													15	81					0	0	0	0	G	50118116	G	G	50118116	3	3	236	1	0	0	0	0	1	0	0	0	7068	188	7	5	1238	5	HEATR3	16	50118116	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	19068863	50118116	40236637	448	43086											
NOD2	64127	broad.mit.edu	37	chr16	50733572	50733572	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgggccagcctctctccCacttggccaggcgccttctg	3	10	10	18	1	2	0	0	0	2	0	5	0	4	0	6	3	1	0	6	3	0	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:50733572C>A	uc002egm.1	+	2	352	c.247C>A	c.(247-249)CAC>AAC	p.H83N	NOD2_uc010cbj.1_Missense_Mutation_p.H56N|NOD2_uc010cbk.1_Missense_Mutation_p.H56N|NOD2_uc002egl.1_5'UTR	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	83	CARD 1.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				GCCTCTCTCCCACTTGGCCAG	0.637													53	49					9.55421e-19	1.8727e-18	1	0	A	50733572	A	A	50733572	3	1	236	1	0	0	0	0	1	0	0	0	10571	594	21	4	253	4	NOD2	16	50733572	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	615456	50733572	39621181	449	43087											
SALL1	6299	broad.mit.edu	37	chr16	51174936	51174936	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaagggctggggaaaaccgaGttagcggaggcttgctgagg	11	6	18	6	2	0	1	0	1	0	0	0	4	0	3	1	6	3	4	1	6	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:51174936G>T	uc010vgs.1	-	2	1228	c.1197C>A	c.(1195-1197)AAC>AAA	p.N399K	SALL1_uc010vgr.1_Missense_Mutation_p.N302K|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	399					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GGAAAACCGAGTTAGCGGAGG	0.498													32	148					1.62565e-12	2.92915e-12	1	0	T	51174936	T	T	51174936	3	4	236	1	0	0	0	0	1	0	0	0	13875	1020	36	4	2785	4	SALL1	16	51174936	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	441364	51174936	39179817	450	43088											
SLC12A3	6559	broad.mit.edu	37	chr16	56899255	56899255	+	Silent	SNP	C	T	T																															gagccctctccaccagctgcCtatgacagcagccaccccag																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:56899255C>T	uc010ccm.2	+	1	137	c.108C>T	c.(106-108)GCC>GCT	p.A36A	SLC12A3_uc002ekd.3_Silent_p.A36A|SLC12A3_uc010ccn.2_Silent_p.A36A	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	36	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	CACCAGCTGCCTATGACAGCA	0.597													35	162					0	0	0	0	T	56899255	T	T	56899255	2	4	236	1	0	0	0	0	0	0	0	1	14449	668	24	4		4	SLC12A3	16	56899255	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5724319	56899255	33455498	451	43089	88	2									
SLC12A3	6559	broad.mit.edu	37	chr16	56899257	56899257	+	Missense_Mutation	SNP	A	T	T																															gccctctccaccagctgcctAtgacagcagccaccccagcc																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:56899257A>T	uc010ccm.2	+	1	139	c.110A>T	c.(109-111)TAT>TTT	p.Y37F	SLC12A3_uc002ekd.3_Missense_Mutation_p.Y37F|SLC12A3_uc010ccn.2_Missense_Mutation_p.Y37F	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	37	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	CCAGCTGCCTATGACAGCAGC	0.597													38	164					0	0	0	0	T	56899257	T	T	56899257	3	4	236	1	0	0	0	0	1	0	0	0	14449	449	16	5	112	5	SLC12A3	16	56899257	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	2	56899257	33455496	452	43090	88	2									
SLC12A3	6559	broad.mit.edu	37	chr16	56917998	56917998	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caatactacaacaagtgggcGgcgctgtttggggctatcat	10	10	12	9	2	1	0	1	0	0	0	1	0	1	0	0	4	3	3	0	4	6	4	rs138625602		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:56917998G>T	uc010ccm.2	+	14	1736	c.1707G>T	c.(1705-1707)GCG>GCT	p.A569A	SLC12A3_uc002ekd.3_Silent_p.A569A|SLC12A3_uc010ccn.2_Silent_p.A568A	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	569	Cytoplasmic (Potential).		A -> V (in GS).|A -> E (in GS).		sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	ACAAGTGGGCGGCGCTGTTTG	0.592													10	83					1.08611e-07	1.7776e-07	1	0	T	56917998	T	T	56917998	2	4	236	1	0	0	0	0	0	0	0	1	14449	1103	39	3		3	SLC12A3	16	56917998	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	18741	56917998	33436755	453	43091											
ZFP90	146198	broad.mit.edu	37	chr16	68591909	68591909	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgattttacaggaatcagtGacattcaaagatgtgtctgt	12	14	10	5	0	3	3	2	2	1	1	3	4	3	4	0	1	1	0	0	1	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:68591909G>A	uc010cff.2	+	3	334	c.42G>A	c.(40-42)GTG>GTA	p.V14V	ZFP90_uc002ewb.2_5'UTR|ZFP90_uc002ewc.2_5'UTR|ZFP90_uc002ewd.2_Silent_p.V14V|ZFP90_uc002ewe.2_Silent_p.V14V	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	14	KRAB.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		AGGAATCAGTGACATTCAAAG	0.463													22	135					0	0	0	0	A	68591909	A	A	68591909	2	1	236	1	0	0	0	0	0	0	0	1	17721	1277	45	2		2	ZFP90	16	68591909	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	11673911	68591909	21762844	454	43092											
HAS3	3038	broad.mit.edu	37	chr16	69148385	69148385	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgggcatgtaccgcaacaGcctcctccagcagttcctgg	7	9	10	15	1	0	0	0	0	0	0	3	0	3	0	5	2	4	5	5	2	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:69148385G>C	uc010cfh.2	+	4	1102	c.878G>C	c.(877-879)AGC>ACC	p.S293T	HAS3_uc002ewk.2_Intron|HAS3_uc002ewl.2_Missense_Mutation_p.S293T	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	293	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		TACCGCAACAGCCTCCTCCAG	0.597													26	87					0	0	0	0	C	69148385	C	C	69148385	3	2	236	1	0	0	0	0	1	0	0	0	7002	971	34	4	888	4	HAS3	16	69148385	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	556476	69148385	21206368	455	43093											
DHX38	9785	broad.mit.edu	37	chr16	72132917	72132917	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacagaagacacttggggTccaccccgcgtctgtccagg	9	7	12	13	2	1	3	0	1	1	2	3	3	3	3	4	3	0	0	4	3	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:72132917T>A	uc002fcb.2	+	6	1211	c.856T>A	c.(856-858)TCC>ACC	p.S286T	DHX38_uc010vmp.1_Intron|DHX38_uc010cgn.1_RNA	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	286					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				ACACTTGGGGTCCACCCCGCG	0.617													8	23					0	0	0	0	A	72132917	A	A	72132917	3	1	236	1	0	0	0	0	1	0	0	0	4533	1667	58	5	874	5	DHX38	16	72132917	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2984532	72132917	18221836	456	43094											
CTRB2	440387	broad.mit.edu	37	chr16	75238069	75238069	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agctgcgggctcagttggcgGccaggatcttctgcacccag	6	8	14	13	2	3	0	1	0	2	0	3	1	3	1	2	4	3	4	2	4	0	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:75238069G>T	uc002fdr.2	-	7	815	c.782C>A	c.(781-783)GCC>GAC	p.A261D		NM_001025200	NP_001020371	Q6GPI1	CTRB2_HUMAN	chymotrypsin B2 precursor	261	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity				0						TCAGTTGGCGGCCAGGATCTT	0.607													51	79					4.17463e-26	8.50516e-26	1	0	T	75238069	T	T	75238069	3	4	236	1	0	0	0	0	1	0	0	0	4043	1203	42	4	13	4	CTRB2	16	75238069	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3105152	75238069	15116684	457	43095											
NUDT7	283927	broad.mit.edu	37	chr16	77759434	77759434	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccgtccttttgccattggtgGctaaagaaggaaaactccat	11	11	9	10	1	0	1	0	0	0	1	2	2	2	2	4	3	2	1	4	3	5	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:77759434G>T	uc010chd.2	+	2	211	c.142G>T	c.(142-144)GCT>TCT	p.A48S	NUDT7_uc002fff.2_Missense_Mutation_p.A48S|NUDT7_uc010vnj.1_Missense_Mutation_p.A48S	NM_001105663	NP_001099133	P0C024	NUDT7_HUMAN	nudix motif 7	48	Nudix hydrolase.				nucleoside diphosphate metabolic process	peroxisome	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|magnesium ion binding|manganese ion binding			ovary(1)|kidney(1)	2						GCCATTGGTGGCTAAAGAAGG	0.428													12	50					0.00136819	0.0020265	1	0	T	77759434	T	T	77759434	3	4	236	1	0	0	0	0	1	0	0	0	10798	1203	42	4	148	4	NUDT7	16	77759434	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2521365	77759434	12595319	458	43096											
VAT1L	57687	broad.mit.edu	37	chr16	77918505	77918505	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aataccacctctctttgcagTggtggcaggtggagaaggtg	9	10	14	8	0	1	1	0	0	1	1	2	2	1	1	2	5	2	2	2	5	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:77918505T>C	uc002ffg.1	+	7	980	c.883T>C	c.(883-885)TGG>CGG	p.W295R		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	295							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						CTCTTTGCAGTGGTGGCAGGT	0.502													8	23					0	0	0	0	C	77918505	C	C	77918505	3	2	236	1	0	0	0	0	1	0	0	0	17198	1710	59	5	909	5	VAT1L	16	77918505	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	159071	77918505	12436248	459	43097											
SNAI3	333929	broad.mit.edu	37	chr16	88747799	88747799	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcagtttttccggagcccCgtgccggtctgggcccaagg	6	8	14	13	3	1	0	0	0	1	0	2	1	2	1	5	4	3	2	5	4	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:88747799C>T	uc002flj.2	-	2	468	c.400G>A	c.(400-402)GGG>AGG	p.G134R	MGC23284_uc002fli.3_Intron	NM_178310	NP_840101	Q3KNW1	SNAI3_HUMAN	snail homolog 3	134					oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.048)		TCCGGAGCCCCGTGCCGGTCT	0.667													59	75					0	0	0	0	T	88747799	T	T	88747799	3	4	236	1	0	0	0	0	1	0	0	0	14892	652	23	1	486	1	SNAI3	16	88747799	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	10829294	88747799	1606954	460	43098											
DPEP1	1800	broad.mit.edu	37	chr16	89696828	89696828	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggaccccaccatgtggagcGgatggtggctgtggcccctt	5	8	16	12	1	0	0	0	0	0	0	0	3	0	3	5	6	1	1	5	6	0	1	rs150374214	byFrequency	TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr16:89696828G>A	uc010cin.2	+	2	213	c.10G>A	c.(10-12)GGA>AGA	p.G4R	DPEP1_uc002fnr.3_Missense_Mutation_p.G4R|DPEP1_uc002fns.3_Missense_Mutation_p.G4R	NM_001128141	NP_001121613	P16444	DPEP1_HUMAN	dipeptidase 1 precursor	4					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(1)	1		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	CATGTGGAGCGGATGGTGGCT	0.632													16	91					0	0	0	0	A	89696828	A	A	89696828	3	1	236	1	0	0	0	0	1	0	0	0	4735	1117	39	1	12	1	DPEP1	16	89696828	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	949029	89696828	657925	461	43099											
KIAA0664	23277	broad.mit.edu	37	chr17	2604689	2604689	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taaaagccccgtgtggacgcGgtgatgctgacttgccggtc	7	9	14	11	4	0	2	0	2	0	0	1	3	0	3	3	3	3	1	3	3	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:2604689G>A	uc002fuy.1	-	6	842	c.756C>T	c.(754-756)ACC>ACT	p.T252T	KIAA0664_uc002fux.1_Silent_p.T184T	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	252							binding			breast(2)	2						GTGTGGACGCGGTGATGCTGA	0.652													10	2					0	0	0	0	A	2604689	A	A	2604689	2	1	236	1	0	0	0	0	0	0	0	1	8228	1103	39	1		1	KIAA0664	17	2604689	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08		2604689	78590521	462	43100											
USP6	9098	broad.mit.edu	37	chr17	5050447	5050447	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgcatttgaaattcctGtcccttcatctccaatttca	8	17	5	11	0	3	1	2	1	1	0	6	1	5	1	3	0	1	1	3	0	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:5050447G>A	uc002gau.1	+	29	4619	c.2389G>A	c.(2389-2391)GTC>ATC	p.V797I	USP6_uc002gav.1_Missense_Mutation_p.V797I|USP6_uc010ckz.1_Missense_Mutation_p.V480I	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	797					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						TGAAATTCCTGTCCCTTCATC	0.398			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								17	39					0	0	0	0	A	5050447	A	A	5050447	3	1	236	1	0	0	0	0	1	0	0	0	17154	1377	48	4	2467	4	USP6	17	5050447	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2445758	5050447	76144763	463	43101											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	5	11	9	16	2	3	0	0	0	3	0	7	1	5	1	3	3	1	1	3	3	0	2	rs28934574		TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	14					0	0	0	0	A	7577094	A	A	7577094	3	1	236	1	0	0	0	0	1	0	0	0	16448	1115	39	1	442	1	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2526647	7577094	73618116	464	43102											
ELAC2	60528	broad.mit.edu	37	chr17	12916588	12916588	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggggcagagtggggccgCacagctacaagaaaaccaca	13	4	13	11	1	1	2	0	0	1	2	1	2	1	2	2	4	3	3	2	4	4	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:12916588C>A	uc002gnz.3	-	6	590	c.495G>T	c.(493-495)GTG>GTT	p.V165V	ELAC2_uc010vvo.1_5'UTR|ELAC2_uc010vvp.1_Silent_p.V146V|ELAC2_uc010vvq.1_Silent_p.V165V|ELAC2_uc010vvr.1_Silent_p.V165V	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	elaC homolog 2 isoform 1	165				V -> M (in Ref. 2; AK001392).	tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding				0						AGTGGGGCCGCACAGCTACAA	0.493									Hereditary_Prostate_Cancer				9	15					3.09899e-07	5.05516e-07	1	0	A	12916588	A	A	12916588	2	1	236	1	0	0	0	0	0	0	0	1	5071	697	25	4		4	ELAC2	17	12916588	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5339494	12916588	68278622	465	43103											
TRIM16	10626	broad.mit.edu	37	chr17	15517267	15517267	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagattgcagggatcgtaccCtggcttggttatgtctgctt	6	15	12	8	1	1	1	0	0	1	1	2	2	1	2	1	3	3	5	1	3	3	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:15517267C>G	uc002gor.1	-	9	2018	c.1681G>C	c.(1681-1683)GGG>CGG	p.G561R	CDRT1_uc002gov.3_Missense_Mutation_p.G251R			O95361	TRI16_HUMAN	SubName: Full=Putative uncharacterized protein; Flags: Fragment;	Error:Variant_position_missing_in_O95361_after_alignment					histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		GGATCGTACCCTGGCTTGGTT	0.478													8	121					0	0	0	0	G	15517267	G	G	15517267	3	3	236	1	0	0	0	0	1	0	0	0	16558	681	24	4		4	TRIM16	17	15517267	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2600679	15517267	65677943	466	43104											
NCOR1	9611	broad.mit.edu	37	chr17	16068406	16068406	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttgaaggtgaagcattttGatcatctccacatggttgcc	9	15	9	8	0	2	3	1	3	1	0	3	3	2	3	2	2	2	2	2	2	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:16068406G>C	uc002gpo.2	-	5	745	c.505C>G	c.(505-507)CAA>GAA	p.Q169E	NCOR1_uc002gpn.2_Missense_Mutation_p.Q169E|NCOR1_uc002gpp.1_Missense_Mutation_p.Q60E|NCOR1_uc002gpr.2_Missense_Mutation_p.Q60E|NCOR1_uc002gps.1_Missense_Mutation_p.Q169E|NCOR1_uc010coz.1_Translation_Start_Site|NCOR1_uc010cpb.1_Missense_Mutation_p.Q169E|NCOR1_uc010cpa.1_Missense_Mutation_p.Q169E|NCOR1_uc002gpu.2_Missense_Mutation_p.Q169E	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	169	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GAAGCATTTTGATCATCTCCA	0.393													3	98					0	0	0	0	C	16068406	C	C	16068406	3	2	236	1	0	0	0	0	1	0	0	0	10289	1299	45	2	6985	2	NCOR1	17	16068406	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	551139	16068406	65126804	467	43105											
C17orf66	256957	broad.mit.edu	37	chr17	34182684	34182684	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacactcttcttcacagccTggtggttttctgcatctagt	6	17	7	11	0	5	0	1	0	4	0	5	0	5	0	1	2	3	2	1	2	2	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:34182684T>A	uc002hke.1	-	14	1498	c.1349A>T	c.(1348-1350)CAG>CTG	p.Q450L	C17orf66_uc010wck.1_RNA|C17orf66_uc010wcl.1_Missense_Mutation_p.Q410L	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957	450							binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		CTTCACAGCCTGGTGGTTTTC	0.532													43	43					0	0	0	0	A	34182684	A	A	34182684	3	1	236	1	0	0	0	0	1	0	0	0	1881	1580	55	5	371	5	C17orf66	17	34182684	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	18114278	34182684	47012526	468	43106											
CCR7	1236	broad.mit.edu	37	chr17	38711638	38711638	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacgcgggcacggtggcggtGagctgagacagcctggacga	8	4	19	10	5	0	2	0	2	0	1	0	6	0	3	1	5	2	2	1	5	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:38711638G>A	uc002huw.2	-	3	556	c.493C>T	c.(493-495)CAC>TAC	p.H165Y		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	165	Cytoplasmic (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				CGGTGGCGGTGAGCTGAGACA	0.552													5	31					0	0	0	0	A	38711638	A	A	38711638	3	1	236	1	0	0	0	0	1	0	0	0	2961	1290	45	2	647	2	CCR7	17	38711638	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4528954	38711638	42483572	469	43107											
BECN1	8678	broad.mit.edu	37	chr17	40970594	40970594	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactcattttcagtgacgttGagctgagtgtccagctggtc	7	13	11	10	1	2	3	2	3	0	0	4	3	3	3	1	1	2	3	1	1	0	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:40970594G>C	uc002ibo.3	-	6	591	c.456C>G	c.(454-456)CTC>CTG	p.L152L	BECN1_uc010whb.1_Silent_p.L65L|BECN1_uc010whc.1_Intron|BECN1_uc002ibn.2_Silent_p.L152L	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	152	Potential.				anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		CAGTGACGTTGAGCTGAGTGT	0.512													14	57					0	0	0	0	C	40970594	C	C	40970594	2	2	236	1	0	0	0	0	0	0	0	1	1398	1277	45	2		2	BECN1	17	40970594	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2258956	40970594	40224616	470	43108											
BRCA1	672	broad.mit.edu	37	chr17	41226510	41226510	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcatgtaccacctatcatCtaatgatgggcatttagaag	12	12	9	8	0	2	2	1	1	1	1	2	2	2	2	2	1	2	3	2	1	5	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:41226510C>T	uc002icq.2	-	14	4745	c.4513G>A	c.(4513-4515)GAT>AAT	p.D1505N	BRCA1_uc010whp.1_Missense_Mutation_p.D354N|BRCA1_uc010whl.1_Missense_Mutation_p.D401N|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.D1434N|BRCA1_uc002icu.2_Missense_Mutation_p.D401N|BRCA1_uc010cyx.2_Missense_Mutation_p.D1458N|BRCA1_uc002ict.2_Missense_Mutation_p.D1526N|BRCA1_uc010whn.1_5'UTR|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Missense_Mutation_p.D234N|BRCA1_uc002idc.1_Missense_Mutation_p.D401N|BRCA1_uc010whr.1_Missense_Mutation_p.D355N	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1505					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CACCTATCATCTAATGATGGG	0.443			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			11	38					0	0	0	0	T	41226510	T	T	41226510	3	4	236	1	0	0	0	0	1	0	0	0	1503	913	32	2	1118	2	BRCA1	17	41226510	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	255916	41226510	39968700	471	43109											
STRADA	92335	broad.mit.edu	37	chr17	61781806	61781806	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtcaccgttggagggccggGgggtgctggtggtcaggctg	4	8	21	8	2	2	0	2	0	0	0	2	1	2	1	2	8	1	3	2	8	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:61781806G>A	uc002jbm.2	-	11	1154	c.995C>T	c.(994-996)CCC>CTC	p.P332L	STRADA_uc002jbn.2_Missense_Mutation_p.P274L|STRADA_uc002jbo.2_Missense_Mutation_p.P295L|STRADA_uc002jbp.2_Missense_Mutation_p.P295L|STRADA_uc002jbq.2_Missense_Mutation_p.P274L|STRADA_uc010wpq.1_Missense_Mutation_p.P288L|STRADA_uc010wpr.1_Missense_Mutation_p.P303L|STRADA_uc010ddw.2_Missense_Mutation_p.P303L|STRADA_uc002jbr.2_3'UTR	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	332	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						GGAGGGCCGGGGGGTGCTGGT	0.642													23	22					0	0	0	0	A	61781806	A	A	61781806	3	1	236	1	0	0	0	0	1	0	0	0	15390	1232	43	4	370	4	STRADA	17	61781806	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	20555296	61781806	19413404	472	43110											
LRRC37A3	374819	broad.mit.edu	37	chr17	62854905	62854905	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tattgtccttacctcaatgaGgcagagaagtataatcaaaa	16	11	7	7	0	2	2	2	1	0	1	3	3	3	2	2	1	1	2	2	1	8	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:62854905G>A	uc002jey.2	-	12	5332	c.4801C>T	c.(4801-4803)CTC>TTC	p.L1601F	LRRC37A3_uc010wqg.1_Missense_Mutation_p.L719F|LRRC37A3_uc002jex.1_Missense_Mutation_p.L578F|LRRC37A3_uc010wqf.1_Missense_Mutation_p.L639F	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1601	Helical; (Potential).					integral to membrane					0						ACCTCAATGAGGCAGAGAAGT	0.378													9	48					0	0	0	0	A	62854905	A	A	62854905	3	1	236	1	0	0	0	0	1	0	0	0	9043	1000	35	4	115	4	LRRC37A3	17	62854905	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1073099	62854905	18340305	473	43111											
RGS9	8787	broad.mit.edu	37	chr17	63133680	63133680	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacaatccgacaccaaggcCagcagtacaggccgaggatg	13	4	12	12	2	0	1	0	1	0	0	1	4	1	2	4	3	2	2	4	3	3	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:63133680C>A	uc002jfe.2	+	1	132	c.22C>A	c.(22-24)CAG>AAG	p.Q8K	RGS9_uc010dem.2_Missense_Mutation_p.Q8K|RGS9_uc002jfd.2_Missense_Mutation_p.Q8K|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	8					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						ACACCAAGGCCAGCAGTACAG	0.617													18	43					4.63292e-17	8.8858e-17	1	0	A	63133680	A	A	63133680	3	1	236	1	0	0	0	0	1	0	0	0	13378	595	21	4	24	4	RGS9	17	63133680	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	278775	63133680	18061530	474	43112											
ITGB4	3691	broad.mit.edu	37	chr17	73738820	73738820	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcggccgccgcctggtaaaCatcaccatcatcaaggagca	11	6	9	15	3	3	0	3	0	0	0	4	1	3	1	4	3	2	2	4	3	3	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:73738820C>T	uc002jpg.2	+	25	3127	c.2940C>T	c.(2938-2940)AAC>AAT	p.N980N	ITGB4_uc002jph.2_Silent_p.N980N|ITGB4_uc002jpi.3_Silent_p.N980N|ITGB4_uc010dgp.1_3'UTR|ITGB4_uc002jpj.2_Silent_p.N980N	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	980	Cytoplasmic (Potential).|Calx-beta.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCTGGTAAACATCACCATCA	0.443													8	69					0	0	0	0	T	73738820	T	T	73738820	2	4	236	1	0	0	0	0	0	0	0	1	7936	477	17	4		4	ITGB4	17	73738820	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	10605140	73738820	7456390	475	43113											
RNF213	57674	broad.mit.edu	37	chr17	78321975	78321975	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgctgggcgggttcgcagcGgagtggctgtcgcaggagta	5	8	19	9	5	0	0	0	0	0	0	3	2	0	2	0	5	1	6	0	5	1	2	rs144070062	byFrequency	TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr17:78321975G>A	uc002jyh.1	+	4	4282	c.4059G>A	c.(4057-4059)GCG>GCA	p.A1353A		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GGTTCGCAGCGGAGTGGCTGT	0.617													31	42					0	0	0	0	A	78321975	A	A	78321975	2	1	236	1	0	0	0	0	0	0	0	1	13542	1103	39	1		1	RNF213	17	78321975	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4583155	78321975	2873235	476	43114											
C18orf1	753	broad.mit.edu	37	chr18	13621178	13621178	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacggtgatggtggtggtcAtcgtctgcctgctgaaccac	6	11	13	11	2	3	2	2	2	1	0	4	2	3	2	2	4	3	1	2	4	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr18:13621178A>T	uc002ksa.2	+	5	912	c.244A>T	c.(244-246)ATC>TTC	p.I82F	C18orf1_uc002ksb.2_Missense_Mutation_p.I82F|C18orf1_uc002kse.2_Missense_Mutation_p.I45F|C18orf1_uc002ksf.2_Missense_Mutation_p.I45F|C18orf1_uc002ksg.1_Missense_Mutation_p.I5F|C18orf1_uc002ksh.1_Missense_Mutation_p.I24F|C18orf1_uc002ksi.1_Missense_Mutation_p.I24F	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	82	Helical; (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		GGTGGTGGTCATCGTCTGCCT	0.617													41	110					0	0	0	0	T	13621178	T	T	13621178	3	4	236	1	0	0	0	0	1	0	0	0	1903	217	8	5	335	5	C18orf1	18	13621178	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08		13621178	64456070	477	43115											
ATP8B1	5205	broad.mit.edu	37	chr18	55368510	55368510	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaagcaggggcactagtgtGgtgtaccaagccagggtaga	12	6	15	8	0	0	1	0	0	0	1	0	1	0	1	2	4	3	4	2	4	5	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr18:55368510G>A	uc002lgw.2	-	4	429	c.429C>T	c.(427-429)ACC>ACT	p.T143T	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	143	Helical; (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GCACTAGTGTGGTGTACCAAG	0.458									Byler_disease				23	18					0	0	0	0	A	55368510	A	A	55368510	2	1	236	1	0	0	0	0	0	0	0	1	1196	1335	47	4		4	ATP8B1	18	55368510	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	41747332	55368510	22708738	478	43116											
CNDP1	84735	broad.mit.edu	37	chr18	72245483	72245483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgatgagcctggaactaaaaCagtcatacctggccgagtta	13	9	10	9	1	1	2	1	2	0	0	1	4	1	3	3	2	4	1	3	2	5	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr18:72245483C>T	uc002llq.2	+	9	1299	c.1088C>T	c.(1087-1089)ACA>ATA	p.T363I	CNDP1_uc002lls.2_Missense_Mutation_p.T166I	NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	363					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		GGAACTAAAACAGTCATACCT	0.423													22	21					0	0	0	0	T	72245483	T	T	72245483	3	4	236	1	0	0	0	0	1	0	0	0	3608	478	17	4	1122	4	CNDP1	18	72245483	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	16876973	72245483	5831765	479	43117											
GALR1	2587	broad.mit.edu	37	chr18	74962925	74962925	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtggccatcgtgcactcgCggcgctcctcctccctcagg	4	8	11	18	5	1	0	1	0	0	0	6	0	4	0	4	3	1	2	4	3	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr18:74962925C>G	uc002lms.3	+	1	918	c.421C>G	c.(421-423)CGG>GGG	p.R141G		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	141	Cytoplasmic (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		CGTGCACTCGCGGCGCTCCTC	0.652													16	18					0	0	0	0	G	74962925	G	G	74962925	3	3	236	1	0	0	0	0	1	0	0	0	6262	759	27	3	423	3	GALR1	18	74962925	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2717442	74962925	3114323	480	43118											
ADNP2	22850	broad.mit.edu	37	chr18	77896155	77896155	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagacctgcaggcccagccGggttttattcacaacagtga	10	9	10	12	1	2	2	2	1	0	1	2	2	2	2	3	2	3	2	3	2	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr18:77896155G>C	uc002lnw.2	+	4	3314	c.2859G>C	c.(2857-2859)CCG>CCC	p.P953P		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	953					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		AGGCCCAGCCGGGTTTTATTC	0.532													22	29					0	0	0	0	C	77896155	C	C	77896155	2	2	236	1	0	0	0	0	0	0	0	1	324	1103	39	3		3	ADNP2	18	77896155	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2933230	77896155	181093	481	43119											
SLC25A23	79085	broad.mit.edu	37	chr19	6442073	6442073	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaataaccttcatgaagttGggggcgatcccccggtagag	10	8	14	9	2	1	2	1	1	0	1	2	4	2	3	3	4	1	2	3	4	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:6442073G>T	uc002mex.1	-	10	1462	c.1320C>A	c.(1318-1320)CCC>CCA	p.P440P	SLC25A23_uc010duu.1_Intron|SLC25A23_uc002meu.2_Intron|SLC25A23_uc002mev.2_Intron|SLC25A23_uc002mew.1_Intron|SLC25A23_uc010xjd.1_Silent_p.P201P	NM_024103	NP_077008	Q9BV35	SCMC3_HUMAN	solute carrier family 25, member 23	440	Solcar 3.|Helical; Name=6; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)|pancreas(1)	2						TCATGAAGTTGGGGGCGATCC	0.622													8	48					0.000274275	0.000410576	1	0	T	6442073	T	T	6442073	2	4	236	1	0	0	0	0	0	0	0	1	14550	1335	47	4		4	SLC25A23	19	6442073	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08		6442073	52686910	482	43120											
RAB11B	9230	broad.mit.edu	37	chr19	8464858	8464858	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggcgtggagttcgccacccGcagcatccaggtggacggca	7	5	15	14	5	0	0	0	0	0	0	2	2	1	2	3	5	1	4	3	5	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:8464858G>T	uc002mju.3	+	2	248	c.152G>T	c.(151-153)CGC>CTC	p.R51L	RAB11B_uc010xkd.1_Missense_Mutation_p.R51L	NM_004218	NP_004209	Q15907	RB11B_HUMAN	RAB11B, member RAS oncogene family	51					cell cycle|protein transport|small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity				0						TTCGCCACCCGCAGCATCCAG	0.662													16	42					1.5739e-10	2.74523e-10	1	0	T	8464858	T	T	8464858	3	4	236	1	0	0	0	0	1	0	0	0	12957	1087	38	3	158	3	RAB11B	19	8464858	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2022785	8464858	50664125	483	43121											
MUC16	94025	broad.mit.edu	37	chr19	9062568	9062568	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagagaagtcacaggaagaGaagcggaagggaaatcctct	17	4	14	6	1	2	2	1	0	1	2	3	8	3	5	1	3	1	0	1	3	6	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:9062568G>T	uc002mkp.2	-	3	25082	c.24878C>A	c.(24877-24879)TCT>TAT	p.S8293Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8295	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CACAGGAAGAGAAGCGGAAGG	0.512													16	79					1.3612e-06	2.1735e-06	1	0	T	9062568	T	T	9062568	3	4	236	1	0	0	0	0	1	0	0	0	10026	942	33	2	18973	2	MUC16	19	9062568	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	597710	9062568	50066415	484	43122											
MUC16	94025	broad.mit.edu	37	chr19	9071210	9071210	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgatgcatggcggcttcTgtgtgtgcagtgtctttgta	6	15	14	6	1	2	1	0	1	2	0	2	2	2	1	0	2	2	4	0	2	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:9071210T>C	uc002mkp.2	-	3	16440	c.16236A>G	c.(16234-16236)ACA>ACG	p.T5412T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5414	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.T5412K(1)		lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGCGGCTTCTGTGTGTGCAG	0.502													93	449					0	0	0	0	C	9071210	C	C	9071210	2	2	236	1	0	0	0	0	0	0	0	1	10026	1567	55	5		5	MUC16	19	9071210	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	8642	9071210	50057773	485	43123											
TSPAN16	26526	broad.mit.edu	37	chr19	11422874	11422874	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcttcaccctgagtgggagCtctctgggagctgcagtgat	7	10	14	10	0	2	2	1	2	1	0	3	4	2	4	1	2	4	4	1	2	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:11422874C>A	uc002mqv.1	+	6	813	c.663C>A	c.(661-663)AGC>AGA	p.S221R	TSPAN16_uc002mqu.1_RNA|uc002mqw.1_Intron	NM_012466	NP_036598	Q9UKR8	TSN16_HUMAN	transmembrane 4 superfamily member 16	221	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						TGAGTGGGAGCTCTCTGGGAG	0.398													4	19					0.00024832	0.000373431	1	0	A	11422874	A	A	11422874	3	1	236	1	0	0	0	0	1	0	0	0	16707	796	28	4	685	4	TSPAN16	19	11422874	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2351664	11422874	47706109	486	43124											
LPPR2	64748	broad.mit.edu	37	chr19	11470311	11470311	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgctatgacagtacctacgCcaagccctacccagggcctg	9	7	9	16	1	0	1	0	1	0	0	0	1	0	1	5	1	5	2	5	1	5	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:11470311C>T	uc002mre.1	+	4	507	c.170C>T	c.(169-171)GCC>GTC	p.A57V	LPPR2_uc002mrf.1_Missense_Mutation_p.A32V|LPPR2_uc010dxy.1_5'Flank	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	57						integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						AGTACCTACGCCAAGCCCTAC	0.602													6	52					0	0	0	0	T	11470311	T	T	11470311	3	4	236	1	0	0	0	0	1	0	0	0	8975	739	26	4	176	4	LPPR2	19	11470311	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	47437	11470311	47658672	487	43125											
ZNF625	90589	broad.mit.edu	37	chr19	12256755	12256756	+	Missense_Mutation	DNP	CC	AA	AA																															cacaatcataaggtttccccCcagtgtgagcccattcatgt																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:12256755_12256756CC>AA	uc002mth.2	-	4	627_628	c.277_278GG>TT	c.(277-279)GGG>TTG	p.G93L	ZNF20_uc002mtg.1_Intron|ZNF625_uc010dyn.1_RNA|ZNF625_uc010dyo.1_Missense_Mutation_p.G127L	NM_145233	NP_660276	Q96I27	ZN625_HUMAN	zinc finger protein 625	93					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGTTTCCCCCCAGTGTGAGCC	0.426													28	97					0	0	0	0	AA	12256756	AA	AA	12256755	3	1	236	1	0	0	0	0	1	0	0	0	18116	623	22	4	646	4	ZNF625	19	12256755	Missense_Mutation	DNP	CC	TCGA-CV-7245-01A-11D-2012-08	786444	12256755	46872228	488	43126											
TECR	9524	broad.mit.edu	37	chr19	14674476	14674476	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttctccccgcagatccgcAgtggtaccccgcccgccagt	5	8	10	18	4	1	1	0	0	1	1	3	1	2	1	7	1	1	4	7	1	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:14674476A>T	uc002mza.2	+	4	252	c.125A>T	c.(124-126)CAG>CTG	p.Q42L	TECR_uc002mzb.2_Missense_Mutation_p.Q57L|TECR_uc010xns.1_5'UTR|TECR_uc002mzc.2_5'UTR|TECR_uc002mzd.2_Missense_Mutation_p.Q42L|TECR_uc002mze.2_5'Flank|TECR_uc002mzf.1_5'Flank	NM_138501	NP_612510	Q9NZ01	TECR_HUMAN	glycoprotein, synaptic 2	42					fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity				0						GCAGATCCGCAGTGGTACCCC	0.701													13	41					0	0	0	0	T	14674476	T	T	14674476	3	4	236	1	0	0	0	0	1	0	0	0	15811	188	7	5	139	5	TECR	19	14674476	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	2417721	14674476	44454507	489	43127											
EMR2	30817	broad.mit.edu	37	chr19	14862462	14862462	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagagatagtgcaaggtacCggcgatgatggagcacagca	13	6	15	7	2	0	2	0	1	0	1	0	5	0	3	1	3	4	5	1	3	4	3	rs143659792	byFrequency	TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:14862462C>G	uc002mzp.1	-	16	2266	c.1810G>C	c.(1810-1812)GGT>CGT	p.G604R	EMR2_uc010dzs.1_Missense_Mutation_p.G63R|EMR2_uc010xnw.1_Missense_Mutation_p.G546R|EMR2_uc002mzo.1_Missense_Mutation_p.G593R|EMR2_uc002mzq.1_Missense_Mutation_p.G544R|EMR2_uc002mzr.1_Missense_Mutation_p.G555R|EMR2_uc002mzs.1_Missense_Mutation_p.G462R|EMR2_uc002mzt.1_Missense_Mutation_p.G500R|EMR2_uc002mzu.1_Missense_Mutation_p.G511R|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	604	Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						TGCAAGGTACCGGCGATGATG	0.567													25	43					0	0	0	0	G	14862462	G	G	14862462	3	3	236	1	0	0	0	0	1	0	0	0	5129	652	23	3	685	3	EMR2	19	14862462	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	187986	14862462	44266521	490	43128											
SLC5A5	6528	broad.mit.edu	37	chr19	18004623	18004623	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaggagctggagggggcTggctcttggaccccctgtgt	6	8	17	10	0	1	1	0	0	1	1	1	4	1	4	2	6	1	3	2	6	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:18004623T>A	uc002nhr.3	+	15	2216	c.1869T>A	c.(1867-1869)GCT>GCA	p.A623A		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	623	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TGGAGGGGGCTGGCTCTTGGA	0.602													5	10					0	0	0	0	A	18004623	A	A	18004623	2	1	236	1	0	0	0	0	0	0	0	1	14732	1567	55	5		5	SLC5A5	19	18004623	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	3142161	18004623	41124360	491	43129											
IL12RB1	3594	broad.mit.edu	37	chr19	18179338	18179338	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgactccagctgtaggttgcTggaaggataagcaaaggcca	12	7	13	9	1	0	0	0	0	0	0	1	3	1	2	2	4	3	5	2	4	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:18179338T>A	uc002nhw.1	-	11	1254	c.1190_splice	c.e11-1	p.A397_splice	IL12RB1_uc010xqb.1_Splice_Site_p.A397_splice|IL12RB1_uc002nhx.1_Splice_Site_p.A437_splice	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1						cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						TGTAGGTTGCTGGAAGGATAA	0.358													33	197					0	0	0	0	A	18179338	A	A	18179338	5	1	236	1	0	0	0	0	0	0	1	0	7665	1594	55	5	828	5	IL12RB1	19	18179338	Splice_Site	SNP	T	TCGA-CV-7245-01A-11D-2012-08	174715	18179338	40949645	492	43130											
HOMER3	9454	broad.mit.edu	37	chr19	19042356	19042356	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagcttccagctgttccaGcgactggccctggcccagcc	6	7	11	17	1	0	1	0	0	0	1	2	2	2	1	5	2	4	3	5	2	0	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:19042356G>T	uc002nku.2	-	7	1422	c.769C>A	c.(769-771)CTG>ATG	p.L257M	HOMER3_uc002nko.1_RNA|HOMER3_uc002nkp.1_RNA|HOMER3_uc010eby.2_Missense_Mutation_p.L221M|HOMER3_uc010ebz.2_Missense_Mutation_p.L257M|HOMER3_uc002nkw.2_Missense_Mutation_p.L257M|HOMER3_uc002nkv.2_Missense_Mutation_p.L257M	NM_004838	NP_004829	Q9NSC5	HOME3_HUMAN	Homer, neuronal immediate early gene, 3 isoform	257	Potential.				metabotropic glutamate receptor signaling pathway|protein targeting	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	protein binding				0			Epithelial(12;0.0107)			AGCTGTTCCAGCGACTGGCCC	0.637													43	91					7.53189e-24	1.52817e-23	1	0	T	19042356	T	T	19042356	3	4	236	1	0	0	0	0	1	0	0	0	7319	962	34	4	328	4	HOMER3	19	19042356	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	863018	19042356	40086627	493	43131											
ZNF737	100129842	broad.mit.edu	37	chr19	20727933	20727933	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccactatgaattatcttgTgtgtagtaagggatgagaag	12	13	11	5	0	1	2	0	2	1	1	2	4	2	3	1	1	0	2	1	1	6	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:20727933T>A	uc002npa.2	-	4	1256	c.1076A>T	c.(1075-1077)CAC>CTC	p.H359L		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	359					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AATTATCTTGTGTGTAGTAAG	0.388													20	73					0	0	0	0	A	20727933	A	A	20727933	3	1	236	1	0	0	0	0	1	0	0	0	18193	1696	59	5	538	5	ZNF737	19	20727933	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	1685577	20727933	38401050	494	43132											
ZNF208	7757	broad.mit.edu	37	chr19	22154889	22154889	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtaaggattgagaatgtacTaaagcctttgccacattctt	13	13	8	7	0	1	1	0	1	1	1	1	3	1	2	2	1	3	2	2	1	5	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:22154889T>C	uc002nqp.2	-	6	2714	c.2565_splice	c.e6-1	p.N855_splice	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GAGAATGTACTAAAGCCTTTG	0.358													30	55					0	0	0	0	C	22154889	C	C	22154889	5	2	236	1	0	0	0	0	0	0	1	0	17833	1522	53	5	899	5	ZNF208	19	22154889	Splice_Site	SNP	T	TCGA-CV-7245-01A-11D-2012-08	1426956	22154889	36974094	495	43133											
ZNF536	9745	broad.mit.edu	37	chr19	30935396	30935396	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgttgtgcgacttcgcggcTtcgcaggaggaggagctcat	7	9	15	10	5	1	0	1	0	0	0	3	4	1	3	0	4	2	4	0	4	0	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:30935396T>A	uc002nsu.1	+	2	1065	c.927T>A	c.(925-927)GCT>GCA	p.A309A	ZNF536_uc010edd.1_Silent_p.A309A	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	309	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					ACTTCGCGGCTTCGCAGGAGG	0.642													84	116					0	0	0	0	A	30935396	A	A	30935396	2	1	236	1	0	0	0	0	0	0	0	1	18041	1596	56	5		5	ZNF536	19	30935396	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	8780507	30935396	28193587	496	43134											
KIRREL2	84063	broad.mit.edu	37	chr19	36357267	36357267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatctcaccacaccccaccCtcgagctttcaccagctaca	10	8	3	20	1	2	0	2	0	1	0	4	1	2	0	5	0	3	2	5	0	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:36357267C>T	uc002ocb.3	+	15	2212	c.2000C>T	c.(1999-2001)CCT>CTT	p.P667L	KIRREL2_uc002obz.3_Intron|KIRREL2_uc002oca.3_Intron|KIRREL2_uc002occ.3_Missense_Mutation_p.P614L|KIRREL2_uc002ocd.3_Missense_Mutation_p.P629L|APLP1_uc010xsz.1_5'Flank|APLP1_uc002oce.2_5'Flank|APLP1_uc002ocf.2_5'Flank|APLP1_uc002ocg.2_5'Flank	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	667	Pro-rich.|Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ACACCCCACCCTCGAGCTTTC	0.612													77	155					0	0	0	0	T	36357267	T	T	36357267	3	4	236	1	0	0	0	0	1	0	0	0	8364	681	24	4	2058	4	KIRREL2	19	36357267	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5421871	36357267	22771716	497	43135											
ZNF222	7673	broad.mit.edu	37	chr19	44536610	44536610	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagccattcaaatgtgaaatAtgtggtaagagcttctgtct	13	13	9	6	0	3	2	1	1	2	1	3	2	3	2	1	1	2	2	1	1	5	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:44536610A>G	uc002oyc.2	+	4	966	c.783A>G	c.(781-783)ATA>ATG	p.I261M	ZNF284_uc010ejd.2_Intron|ZNF222_uc002oye.2_Missense_Mutation_p.I301M|ZNF222_uc002oyd.2_Missense_Mutation_p.I207M	NM_013360	NP_037492	Q9UK12	ZN222_HUMAN	zinc finger protein 222 isoform 2	261	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Prostate(69;0.0435)				AATGTGAAATATGTGGTAAGA	0.393													39	99					0	0	0	0	G	44536610	G	G	44536610	3	3	236	1	0	0	0	0	1	0	0	0	17843	439	16	5	936	5	ZNF222	19	44536610	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	8179343	44536610	14592373	498	43136											
LIG1	3978	broad.mit.edu	37	chr19	48620966	48620966	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacctcccacacagcgctggGgtccagccagtggtcgggaa	8	5	13	15	2	0	0	0	0	0	0	3	1	2	1	4	4	2	1	4	4	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:48620966G>A	uc002pia.1	-	26	2632	c.2512C>T	c.(2512-2514)CCC>TCC	p.P838S	LIG1_uc010xze.1_Missense_Mutation_p.P531S|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.P770S|LIG1_uc010xzg.1_Missense_Mutation_p.P807S	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	838					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	ACAGCGCTGGGGTCCAGCCAG	0.662								NER					12	26					0	0	0	0	A	48620966	A	A	48620966	3	1	236	1	0	0	0	0	1	0	0	0	8822	1232	43	4	259	4	LIG1	19	48620966	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4084356	48620966	10508017	499	43137											
HRC	3270	broad.mit.edu	37	chr19	49658346	49658346	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctctgctgatgcctcctcgGagagcccggcgactccagtg	5	8	13	15	3	1	2	0	1	1	1	4	4	3	2	4	2	3	2	4	2	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:49658346G>T	uc002pmv.2	-	1	336	c.149C>A	c.(148-150)TCC>TAC	p.S50Y	TRPM4_uc002pmw.2_5'Flank|TRPM4_uc010emu.2_5'Flank|TRPM4_uc010yak.1_5'Flank|TRPM4_uc002pmx.2_5'Flank|TRPM4_uc010emv.2_5'Flank|TRPM4_uc010yal.1_5'Flank	NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	50					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		TGCCTCCTCGGAGAGCCCGGC	0.602													19	93					2.32416e-17	4.50162e-17	1	0	T	49658346	T	T	49658346	3	4	236	1	0	0	0	0	1	0	0	0	7391	1174	41	2	1974	2	HRC	19	49658346	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1037380	49658346	9470637	500	43138											
LRRC4B	94030	broad.mit.edu	37	chr19	51022385	51022385	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgcctccgagatgtattcCagccgcttgagctcgcccag	6	8	11	16	4	0	2	0	1	0	1	3	3	2	2	6	0	2	3	6	0	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:51022385C>A	uc002pss.2	-	3	722	c.585G>T	c.(583-585)CTG>CTT	p.L195L		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	195	LRR 5.|Extracellular (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		AGATGTATTCCAGCCGCTTGA	0.652													9	28					2.17888e-05	3.37485e-05	1	0	A	51022385	A	A	51022385	2	1	236	1	0	0	0	0	0	0	0	1	9057	581	21	4		4	LRRC4B	19	51022385	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1364039	51022385	8106598	501	43139											
ZNF616	90317	broad.mit.edu	37	chr19	52619407	52619407	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatgtacagtgaggtttgagCtccgtttaaaggttttgcca	9	14	12	6	1	0	2	0	2	0	0	1	3	1	2	2	2	3	5	2	2	3	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:52619407C>A	uc002pym.2	-	4	1293	c.1010G>T	c.(1009-1011)AGC>ATC	p.S337I	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	337	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		GAGGTTTGAGCTCCGTTTAAA	0.398													32	120					6.50621e-10	1.11893e-09	1	0	A	52619407	A	A	52619407	3	1	236	1	0	0	0	0	1	0	0	0	18108	797	28	4	1339	4	ZNF616	19	52619407	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1597022	52619407	6509576	502	43140											
VN1R2	317701	broad.mit.edu	37	chr19	53761833	53761833	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctttcatctctttgtcttGtgtctttatttctacactct	4	24	3	10	0	7	0	1	0	6	0	8	0	7	0	0	0	1	0	0	0	2	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:53761833G>C	uc002qbi.2	+	1	289	c.205G>C	c.(205-207)GTG>CTG	p.V69L		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	69	Helical; Name=1; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		tctttgtcttgtgtctttatt	0.055													4	7					0	0	0	0	C	53761833	C	C	53761833	3	2	236	1	0	0	0	0	1	0	0	0	17247	1377	48	4	207	4	VN1R2	19	53761833	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1142426	53761833	5367150	503	43141											
NLRP12	91662	broad.mit.edu	37	chr19	54313795	54313795	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtggaaatacttgtagaagTattccttcctttctgcctca	9	16	7	9	0	2	1	1	0	1	1	4	2	4	2	3	1	2	2	3	1	5	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:54313795T>A	uc002qch.3	-	3	1338	c.1118A>T	c.(1117-1119)TAC>TTC	p.Y373F	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.Y373F|NLRP12_uc002qcj.3_Missense_Mutation_p.Y373F|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.Y373F	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	373	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CTTGTAGAAGTATTCCTTCCT	0.557													79	225					0	0	0	0	A	54313795	A	A	54313795	3	1	236	1	0	0	0	0	1	0	0	0	10528	1638	57	5	2195	5	NLRP12	19	54313795	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	551962	54313795	4815188	504	43142											
KIR3DL1	3811	broad.mit.edu	37	chr19	55377864	55377864	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagcctgcgggggacagaaCagtgaataggcaggtaggtc	12	5	17	7	1	0	3	0	1	0	2	1	4	0	4	1	5	3	2	1	5	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:55377864C>A	uc002qhl.3	+	8	1208	c.1145C>A	c.(1144-1146)ACA>AAA	p.T382K	KIR3DL2_uc010esh.2_Missense_Mutation_p.T365K|KIR3DL2_uc002qho.3_Missense_Mutation_p.T382K			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	382	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GGGGACAGAACAGTGAATAGG	0.532													25	123					1.85244e-09	3.16365e-09	1	0	A	55377864	A	A	55377864	3	1	236	1	0	0	0	0	1	0	0	0	8359	478	17	4		4	KIR3DL1	19	55377864	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1064069	55377864	3751119	505	43143											
NLRP11	204801	broad.mit.edu	37	chr19	56300307	56300307	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaagaacagaggcaagagaTcgacagcaggcactggttaa	16	5	13	7	1	0	3	0	0	0	3	1	5	0	3	0	3	2	5	0	3	4	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:56300307T>A	uc010ygf.1	-	11	3432	c.2721A>T	c.(2719-2721)CGA>CGT	p.R907R	NLRP11_uc002qlz.2_Silent_p.R754R|NLRP11_uc002qmb.2_Silent_p.R808R|NLRP11_uc002qmc.2_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	907							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		AGGCAAGAGATCGACAGCAGG	0.458													14	36					0	0	0	0	A	56300307	A	A	56300307	2	1	236	1	0	0	0	0	0	0	0	1	10527	1422	50	5		5	NLRP11	19	56300307	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08	922443	56300307	2828676	506	43144											
ZFP28	140612	broad.mit.edu	37	chr19	57066324	57066324	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaacatcaaagactgcacActggccaaagaccttatgaa	16	7	6	12	0	2	3	2	1	0	2	2	3	2	3	2	1	2	1	2	1	5	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:57066324A>G	uc002qnj.2	+	8	2241	c.2170A>G	c.(2170-2172)ACT>GCT	p.T724A	uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	724					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		AAGACTGCACACTGGCCAAAG	0.413													19	59					0	0	0	0	G	57066324	G	G	57066324	3	3	236	1	0	0	0	0	1	0	0	0	17709	159	6	5	2200	5	ZFP28	19	57066324	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	766017	57066324	2062659	507	43145											
ZNF530	348327	broad.mit.edu	37	chr19	58118332	58118332	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttgcaaaactgacctcattcGacaccagacagttcacactg	13	9	6	13	1	2	2	2	1	0	1	3	3	2	2	2	0	2	2	2	0	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:58118332G>C	uc002qpk.2	+	3	1659	c.1439G>C	c.(1438-1440)CGA>CCA	p.R480P	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	480	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GACCTCATTCGACACCAGACA	0.438													35	33					0	0	0	0	C	58118332	C	C	58118332	3	2	236	1	0	0	0	0	1	0	0	0	18038	1058	37	3	1449	3	ZNF530	19	58118332	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	1052008	58118332	1010651	508	43146											
ZNF587	84914	broad.mit.edu	37	chr19	58370975	58370975	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggcaacctcgttcaccatCagcgaggtcatactggagaa	12	7	11	11	2	3	1	3	0	0	1	4	3	3	1	2	3	3	2	2	3	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr19:58370975C>T	uc002qql.2	+	3	1333	c.1195C>T	c.(1195-1197)CAG>TAG	p.Q399*	ZNF587_uc002qqb.2_Nonsense_Mutation_p.Q356*|ZNF587_uc010yhh.1_Nonsense_Mutation_p.Q356*|ZNF587_uc002qqi.1_Nonsense_Mutation_p.Q356*|ZNF587_uc002qqj.1_RNA|ZNF814_uc002qqk.2_Intron|ZNF587_uc010yhk.1_Nonsense_Mutation_p.Q398*	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	399	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		CGTTCACCATCAGCGAGGTCA	0.473													66	97					0	0	0	0	T	58370975	T	T	58370975	4	4	236	1	0	0	0	0	0	1	0	0	18087	827	29	2	1205	2	ZNF587	19	58370975	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	252643	58370975	758008	509	43147											
SIGLEC1	6614	broad.mit.edu	37	chr20	3675353	3675353	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagctaggctcgtggtggcTgagcctggggcctgggcttg	3	9	19	10	1	0	1	0	1	0	0	1	1	0	1	2	6	2	5	2	6	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:3675353T>A	uc002wja.2	-	11	2901	c.2901A>T	c.(2899-2901)TCA>TCT	p.S967S	SIGLEC1_uc002wjb.1_5'Flank|SIGLEC1_uc002wiz.3_Silent_p.S967S	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	967	Ig-like C2-type 9.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						TCGTGGTGGCTGAGCCTGGGG	0.622													15	60					0	0	0	0	A	3675353	A	A	3675353	2	1	236	1	0	0	0	0	0	0	0	1	14370	1567	55	5		5	SIGLEC1	20	3675353	Silent	SNP	T	TCGA-CV-7245-01A-11D-2012-08		3675353	59350167	510	43148											
SIGLEC1	6614	broad.mit.edu	37	chr20	3677790	3677790	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccagcctcagtcaggatgcgGcaggcgtaaagggcagcatc	10	5	14	12	2	2	0	2	0	0	0	3	1	2	1	2	4	3	4	2	4	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:3677790G>A	uc002wja.2	-	9	2322	c.2322C>T	c.(2320-2322)TGC>TGT	p.C774C	SIGLEC1_uc002wiz.3_Silent_p.C774C	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	774	Ig-like C2-type 7.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						TCAGGATGCGGCAGGCGTAAA	0.637													23	62					0	0	0	0	A	3677790	A	A	3677790	2	1	236	1	0	0	0	0	0	0	0	1	14370	1195	42	4		4	SIGLEC1	20	3677790	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2437	3677790	59347730	511	43149											
LRRN4	164312	broad.mit.edu	37	chr20	6021815	6021815	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acggtgctggcgagcaacagGccgctggcggcgcacagccc	7	3	16	15	5	0	0	0	0	0	0	0	1	0	0	2	5	4	4	2	5	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:6021815G>T	uc002wmo.2	-	5	2300	c.2076C>A	c.(2074-2076)GGC>GGA	p.G692G		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	692	Helical; (Potential).					integral to membrane				skin(3)	3						CGAGCAACAGGCCGCTGGCGG	0.697													4	17					2.56e-06	4.05471e-06	1	0	T	6021815	T	T	6021815	2	4	236	1	0	0	0	0	0	0	0	1	9087	1190	42	4		4	LRRN4	20	6021815	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2344025	6021815	57003705	512	43150											
JAG1	182	broad.mit.edu	37	chr20	10653648	10653648	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgaactgacccgaggcccCacacacctgccggcgaggga	9	3	12	17	4	0	1	0	1	0	0	1	5	0	2	5	3	2	0	5	3	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:10653648C>A	uc002wnw.2	-	2	604	c.88G>T	c.(88-90)GGG>TGG	p.G30W		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	30					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						CCCGAGGCCCCACACACCTGC	0.647									Alagille_Syndrome				9	61					3.86212e-05	5.90748e-05	1	0	A	10653648	A	A	10653648	3	1	236	1	0	0	0	0	1	0	0	0	7973	594	21	4	3668	4	JAG1	20	10653648	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4631833	10653648	52371872	513	43151											
C20orf7	79133	broad.mit.edu	37	chr20	13789488	13789488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttctttttctttttaaatagGacactgatgaaattcaagtt	12	19	5	5	0	3	2	1	2	2	0	3	3	3	3	0	1	0	1	0	1	5	9			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:13789488G>A	uc002wom.2	+	8	751	c.718G>A	c.(718-720)GAC>AAC	p.D240N	C20orf7_uc002won.2_Missense_Mutation_p.D212N|C20orf7_uc002woo.2_RNA	NM_024120	NP_077025	Q5TEU4	CT007_HUMAN	hypothetical protein LOC79133 isoform 1	240					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity				0		Myeloproliferative disorder(85;0.00878)				TTTTAAATAGGACACTGATGA	0.209													18	25					0	0	0	0	A	13789488	A	A	13789488	3	1	236	1	0	0	0	0	1	0	0	0	2125	1188	41	2	768	2	C20orf7	20	13789488	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3135840	13789488	49236032	514	43152											
SEL1L2	80343	broad.mit.edu	37	chr20	13840045	13840045	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtcccatagccatagtaatGgtaatctccaatttttactc	12	14	5	10	0	1	0	0	0	1	0	4	0	2	0	3	1	2	2	3	1	6	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:13840045G>T	uc010gcf.2	-	18	1763	c.1681C>A	c.(1681-1683)CAT>AAT	p.H561N	SEL1L2_uc002woq.3_Missense_Mutation_p.H422N|SEL1L2_uc010zrl.1_Intron|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	561	Extracellular (Potential).|Sel1-like 10.					integral to membrane	binding			ovary(2)	2						CCATAGTAATGGTAATCTCCA	0.368													6	39					8.12818e-05	0.000123558	1	0	T	13840045	T	T	13840045	3	4	236	1	0	0	0	0	1	0	0	0	14076	1348	47	4	397	4	SEL1L2	20	13840045	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	50557	13840045	49185475	515	43153											
SEL1L2	80343	broad.mit.edu	37	chr20	13868451	13868451	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttgtaataacttagggcaaCttcacaattctgtagaacat	14	13	6	8	0	2	1	1	0	1	1	2	1	2	1	0	1	3	3	0	1	7	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:13868451C>T	uc010gcf.2	-	8	791	c.709G>A	c.(709-711)GTT>ATT	p.V237I	SEL1L2_uc002woq.3_Missense_Mutation_p.V98I|SEL1L2_uc010zrl.1_Missense_Mutation_p.V237I|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	237	Sel1-like 4.|Extracellular (Potential).					integral to membrane	binding			ovary(2)	2						CTTAGGGCAACTTCACAATTC	0.308													24	115					0	0	0	0	T	13868451	T	T	13868451	3	4	236	1	0	0	0	0	1	0	0	0	14076	565	20	4	1409	4	SEL1L2	20	13868451	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	28406	13868451	49157069	516	43154											
BFSP1	631	broad.mit.edu	37	chr20	17492691	17492691	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgctgcaggatgctgataTaggtctgaacttccagaaga	11	11	11	8	0	2	4	0	2	2	2	3	5	3	5	1	2	4	3	1	2	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:17492691T>C	uc002wpo.2	-	4	596	c.557A>G	c.(556-558)TAT>TGT	p.Y186C	BFSP1_uc002wpp.2_Missense_Mutation_p.Y61C|BFSP1_uc010zrn.1_Missense_Mutation_p.Y47C|BFSP1_uc010zro.1_Missense_Mutation_p.Y47C	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	186	Rod.|Linker 12.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						GATGCTGATATAGGTCTGAAC	0.463													34	41					0	0	0	0	C	17492691	C	C	17492691	3	2	236	1	0	0	0	0	1	0	0	0	1418	1406	49	5	1460	5	BFSP1	20	17492691	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	3624240	17492691	45532829	517	43155											
ZNF133	7692	broad.mit.edu	37	chr20	18296949	18296949	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccaacctcatcagacaccAgaggacgcactcaggcgaga	14	4	9	14	2	3	3	3	0	0	3	4	5	4	4	3	2	1	1	3	2	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:18296949A>G	uc010gcq.2	+	5	1759	c.1454A>G	c.(1453-1455)CAG>CGG	p.Q485R	ZNF133_uc010zrv.1_Missense_Mutation_p.Q488R|ZNF133_uc010zrw.1_Missense_Mutation_p.Q422R|ZNF133_uc010gcr.2_Missense_Mutation_p.Q485R|ZNF133_uc010zrx.1_Missense_Mutation_p.Q390R|ZNF133_uc002wql.3_Missense_Mutation_p.Q484R|ZNF133_uc010gcs.2_Missense_Mutation_p.Q484R|ZNF133_uc010zry.1_Missense_Mutation_p.Q390R|ZNF133_uc002wqm.2_Missense_Mutation_p.Q485R	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	485	C2H2-type 10.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						ATCAGACACCAGAGGACGCAC	0.582													21	55					0	0	0	0	G	18296949	G	G	18296949	3	3	236	1	0	0	0	0	1	0	0	0	17790	188	7	5	1461	5	ZNF133	20	18296949	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	804258	18296949	44728571	518	43156											
ZNF133	7692	broad.mit.edu	37	chr20	18297420	18297420	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcagcccgaccctgagcCgtgtgcagggcaaccttcgg	7	6	14	14	3	0	1	0	1	0	0	1	2	0	1	4	2	5	3	4	2	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:18297420C>T	uc010gcq.2	+	5	2230	c.1925C>T	c.(1924-1926)CCG>CTG	p.P642L	ZNF133_uc010zrv.1_Missense_Mutation_p.P645L|ZNF133_uc010zrw.1_Missense_Mutation_p.P579L|ZNF133_uc010gcr.2_Missense_Mutation_p.P642L|ZNF133_uc010zrx.1_Missense_Mutation_p.P547L|ZNF133_uc002wql.3_Missense_Mutation_p.P641L|ZNF133_uc010gcs.2_Missense_Mutation_p.P641L|ZNF133_uc010zry.1_Missense_Mutation_p.P547L|ZNF133_uc002wqm.2_Missense_Mutation_p.P642L	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	642						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						GACCCTGAGCCGTGTGCAGGG	0.537													23	89					0	0	0	0	T	18297420	T	T	18297420	3	4	236	1	0	0	0	0	1	0	0	0	17790	652	23	1	1932	1	ZNF133	20	18297420	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	471	18297420	44728100	519	43157											
INSM1	3642	broad.mit.edu	37	chr20	20350324	20350325	+	Frame_Shift_Ins	INS	-	A	A																															ccgcccaggtgttcccctgcINSaagtactgcccggccacctt																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:20350324_20350325insA	uc002wrx.2	+	1	1560_1561	c.1413_1414insA	c.(1411-1416)TGCAAGfs	p.C471fs		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	471_472	C2H2-type 5.				endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		TGTTCCCCTGCAAGTACTGCCC	0.658													---	---	---								A	20350325	A	A	20350324	7	5	236	1	0	1	1	0	0	0	0	0	7810	718	25	0	1415	0	INSM1	20	20350324	Frame_Shift_Ins	INS	-	TCGA-CV-7245-01A-11D-2012-08	2052904	20350324	42675196	520	43158											
VSX1	30813	broad.mit.edu	37	chr20	25057164	25057164	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcctggcttccttatcatCcccatggattttttatgcat	6	18	5	12	0	1	0	1	0	0	0	4	1	4	1	4	2	1	2	4	2	2	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:25057164C>A	uc002wuf.2	-	5	866	c.831G>T	c.(829-831)GGG>GGT	p.G277G	VSX1_uc002wue.2_Intron|VSX1_uc010gdd.1_Intron|VSX1_uc010gde.1_Intron|VSX1_uc010gdf.1_Intron	NM_014588	NP_055403	Q9NZR4	VSX1_HUMAN	visual system homeobox 1 isoform a	277	CVC.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCCTTATCATCCCCATGGATT	0.343													25	109					3.01185e-09	5.11702e-09	1	0	A	25057164	A	A	25057164	2	1	236	1	0	0	0	0	0	0	0	1	17299	842	30	2		2	VSX1	20	25057164	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4706840	25057164	37968356	521	43159											
REM1	28954	broad.mit.edu	37	chr20	30065673	30065673	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacggtggatggagaagacaCcacactggtggtcgtggaca	11	6	15	9	2	0	2	0	0	0	2	1	5	0	4	1	6	0	0	1	6	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:30065673C>A	uc002wwa.2	+	3	667	c.383C>A	c.(382-384)ACC>AAC	p.T128N		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	128					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GGAGAAGACACCACACTGGTG	0.562													9	24					0.000673444	0.00100049	1	0	A	30065673	A	A	30065673	3	1	236	1	0	0	0	0	1	0	0	0	13287	507	18	4	389	4	REM1	20	30065673	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	5008509	30065673	32959847	522	43160											
PLUNC	51297	broad.mit.edu	37	chr20	31825963	31825963	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggtacttctggtggcctccTtgggggactgcttggaaaag	7	11	15	8	0	1	0	0	0	1	0	2	2	2	2	2	6	2	2	2	6	3	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:31825963T>A	uc002wyv.2	+	3	333	c.263T>A	c.(262-264)CTT>CAT	p.L88H	PLUNC_uc002wyt.3_Missense_Mutation_p.L88H|PLUNC_uc002wyu.3_Missense_Mutation_p.L88H	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	88					innate immune response	extracellular region	lipid binding				0						GGTGGCCTCCTTGGGGGACTG	0.537													25	97					0	0	0	0	A	31825963	A	A	31825963	3	1	236	1	0	0	0	0	1	0	0	0	12170	1609	56	5	269	5	PLUNC	20	31825963	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	1760290	31825963	31199557	523	43161											
ITCH	83737	broad.mit.edu	37	chr20	33033227	33033227	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctacagcgtagtcagcttcaAggagcaatgcagcagtttaa	13	9	10	9	1	2	0	2	0	0	0	2	1	2	1	0	1	6	6	0	1	5	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:33033227A>T	uc010geu.1	+	12	1416	c.1224A>T	c.(1222-1224)CAA>CAT	p.Q408H	ITCH_uc002xak.2_Missense_Mutation_p.Q367H|ITCH_uc010zuj.1_Missense_Mutation_p.Q257H	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	408	Required for interaction with FYN.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						GTCAGCTTCAAGGAGCAATGC	0.433													8	55					0	0	0	0	T	33033227	T	T	33033227	3	4	236	1	0	0	0	0	1	0	0	0	7907	69	3	5	1135	5	ITCH	20	33033227	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	1207264	33033227	29992293	524	43162											
CHD6	84181	broad.mit.edu	37	chr20	40101970	40101970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctagtggttacctgcaagtCattttgtgggttccagtcag	7	14	11	9	0	2	0	2	0	0	0	3	0	3	0	3	2	2	3	3	2	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:40101970C>T	uc002xka.1	-	17	2834	c.2656G>A	c.(2656-2658)GAC>AAC	p.D886N	CHD6_uc002xkd.2_Missense_Mutation_p.D864N	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	886	Helicase C-terminal.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				ACCTGCAAGTCATTTTGTGGG	0.498													6	52					0	0	0	0	T	40101970	T	T	40101970	3	4	236	1	0	0	0	0	1	0	0	0	3344	826	29	2	5575	2	CHD6	20	40101970	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	7068743	40101970	22923550	525	43163											
RIMS4	140730	broad.mit.edu	37	chr20	43399968	43399968	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcaatggactcgtggctggCctggcgcagtgtccggctgg	4	9	16	12	3	1	0	1	0	0	0	3	1	2	1	2	6	0	3	2	6	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:43399968C>G	uc002xms.2	-	2	184	c.184G>C	c.(184-186)GCC>CCC	p.A62P	RIMS4_uc010ggu.2_Missense_Mutation_p.A63P	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	62					exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				TCGTGGCTGGCCTGGCGCAGT	0.627													15	89					0	0	0	0	G	43399968	G	G	43399968	3	3	236	1	0	0	0	0	1	0	0	0	13435	739	26	4	645	4	RIMS4	20	43399968	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3297998	43399968	19625552	526	43164											
PREX1	57580	broad.mit.edu	37	chr20	47246080	47246080	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaggccggcgcccacactcCcagcagcaccaggctttggg	7	5	13	16	2	0	1	0	1	0	0	1	1	1	1	4	4	2	3	4	4	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:47246080C>T	uc002xtw.1	-	37	4696	c.4673G>A	c.(4672-4674)GGG>GAG	p.G1558E	PREX1_uc002xtv.1_Missense_Mutation_p.G855E	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1558					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCCCACACTCCCAGCAGCACC	0.622													26	108					0	0	0	0	T	47246080	T	T	47246080	3	4	236	1	0	0	0	0	1	0	0	0	12538	623	22	4	322	4	PREX1	20	47246080	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3846112	47246080	15779440	527	43165											
ADNP	23394	broad.mit.edu	37	chr20	49508160	49508160	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcaacttttccataggaacTattcttccatttcaactgct	10	17	3	11	0	3	0	2	0	1	0	5	1	5	1	2	1	4	1	2	1	5	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:49508160T>A	uc002xvt.1	-	5	3436	c.3091A>T	c.(3091-3093)AGT>TGT	p.S1031C	ADNP_uc002xvu.1_Missense_Mutation_p.S1031C	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	1031						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						CCATAGGAACTATTCTTCCAT	0.458													31	120					0	0	0	0	A	49508160	A	A	49508160	3	1	236	1	0	0	0	0	1	0	0	0	323	1522	53	5	221	5	ADNP	20	49508160	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	2262080	49508160	13517360	528	43166											
ZNF831	128611	broad.mit.edu	37	chr20	57829617	57829617	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggtaggaaacgtcaggtatCtggattaatcactcggaaag	13	9	12	7	3	3	0	2	0	1	0	4	3	3	3	0	5	1	2	0	5	5	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:57829617C>G	uc002yan.2	+	5	4853	c.4853C>G	c.(4852-4854)TCT>TGT	p.S1618C		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1618						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CGTCAGGTATCTGGATTAATC	0.488													21	98					0	0	0	0	G	57829617	G	G	57829617	3	3	236	1	0	0	0	0	1	0	0	0	18252	913	32	2	4871	2	ZNF831	20	57829617	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	8321457	57829617	5195903	529	43167											
CDH4	1002	broad.mit.edu	37	chr20	60511804	60511804	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgacccccagggactccgcGctgctgacaacgaccccacg	8	4	11	18	4	0	2	0	2	0	0	1	4	1	3	5	1	2	2	5	1	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:60511804G>T	uc002ybn.1	+	16	2568	c.2554G>T	c.(2554-2556)GCT>TCT	p.A852S	CDH4_uc002ybp.1_Missense_Mutation_p.A778S|uc002ybr.1_5'Flank	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	852	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GGGACTCCGCGCTGCTGACAA	0.642													8	43					5.18039e-06	8.13943e-06	1	0	T	60511804	T	T	60511804	3	4	236	1	0	0	0	0	1	0	0	0	3127	1087	38	3	2616	3	CDH4	20	60511804	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2682187	60511804	2513716	530	43168											
TAF4	6874	broad.mit.edu	37	chr20	60574130	60574130	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaaaacttgagctgtgccCggacgtcactcgcctgctca	10	8	9	14	3	2	1	2	1	0	0	3	2	2	2	2	1	4	2	2	1	3	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:60574130C>A	uc002ybs.2	-	12	2822	c.2822G>T	c.(2821-2823)CGG>CTG	p.R941L		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	941					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			GAGCTGTGCCCGGACGTCACT	0.483													108	467					2.21197e-46	4.69148e-46	1	0	A	60574130	A	A	60574130	3	1	236	1	0	0	0	0	1	0	0	0	15592	652	23	3	451	3	TAF4	20	60574130	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	62326	60574130	2451390	531	43169											
HRH3	11255	broad.mit.edu	37	chr20	60791520	60791520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacggagccgcccccaccgcCacccccgagggtcgcctccc	5	2	10	24	5	0	0	0	0	0	0	2	2	1	1	9	2	1	0	9	2	0	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	bdc58b10-1756-45bf-a34f-fa4095429476	g.chr20:60791520C>T	uc002ycf.2	-	3	1177	c.880G>A	c.(880-882)GGC>AGC	p.G294S	HRH3_uc002ycg.2_Intron|HRH3_uc002ych.2_Intron|HRH3_uc002yci.2_Missense_Mutation_p.G294S	NM_007232	NP_009163	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	294	Poly-Gly.|Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	CCCCCACCGCCACCCCCGAGG	0.731													3	7					0	0	0	0	T	60791520	T	T	60791520	3	4	236	1	0	0	0	0	1	0	0	0	7396	594	21	4	461	4	HRH3	20	60791520	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	217390	60791520	2234000	532	43170											
C20orf135	140701	broad.mit.edu	37	chr20	62493624	62493624	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcccgcgcacctggtggtctAcggctggtctgttggcggct	2	10	16	13	4	2	0	0	0	2	0	2	0	2	0	2	6	1	4	2	6	1	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr20:62493624A>T	uc002ygx.1	+	1	1059	c.731A>T	c.(730-732)TAC>TTC	p.Y244F	TPD52L2_uc002ygy.2_5'Flank|TPD52L2_uc002ygz.2_5'Flank|TPD52L2_uc002yha.2_5'Flank|TPD52L2_uc002yhb.2_5'Flank|TPD52L2_uc002yhc.2_5'Flank|TPD52L2_uc002yhd.2_5'Flank|TPD52L2_uc011abk.1_5'Flank|TPD52L2_uc011abl.1_5'Flank	NM_080622	NP_542189	Q9H3Z7	ABHGB_HUMAN	hypothetical protein LOC140701	244							hydrolase activity				0	all_cancers(38;1.77e-12)|all_epithelial(29;3.12e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					CTGGTGGTCTACGGCTGGTCT	0.677													9	26					0	0	0	0	T	62493624	T	T	62493624	3	4	236	1	0	0	0	0	1	0	0	0	2098	391	14	5	733	5	C20orf135	20	62493624	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	1702104	62493624	531896	533	43171											
BAGE2	85319	broad.mit.edu	37	chr21	11058282	11058282	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggtacatttctcttcacaGcatttgatagtggctccaaa	10	14	8	9	0	2	1	1	1	1	0	4	1	3	1	1	2	2	3	1	2	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr21:11058282G>A	uc002yit.1	-	3	366	c.158C>T	c.(157-159)GCT>GTT	p.A53V	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCTCTTCACAGCATTTGATAG	0.403													5	140					0	0	0	0	A	11058282	A	A	11058282	3	1	236	1	0	0	0	0	1	0	0	0	1294	971	34	4	179	4	BAGE2	21	11058282	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08		11058282	37071613	534	43172											
GART	2618	broad.mit.edu	37	chr21	34878379	34878379	+	Silent	SNP	G	T	T																															tgcagagctatttggttcccGagtactgtctataagtgctt																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr21:34878379G>T	uc002yrx.2	-	19	2620	c.2485C>A	c.(2485-2487)CGG>AGG	p.R829R	GART_uc002yrz.2_Silent_p.R829R|GART_uc010gmd.2_Silent_p.R491R|GART_uc002yry.2_Silent_p.R829R	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	829	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	TTTGGTTCCCGAGTACTGTCT	0.383													45	49					1.41504e-22	2.83007e-22	1	0	T	34878379	T	T	34878379	2	4	236	1	0	0	0	0	0	0	0	1	6278	1057	37	3		3	GART	21	34878379	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	23820097	34878379	13251516	535	43173	89	2									
GART	2618	broad.mit.edu	37	chr21	34878381	34878381	+	Missense_Mutation	SNP	G	A	A																															cagagctatttggttcccgaGtactgtctataagtgcttgc																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr21:34878381G>A	uc002yrx.2	-	19	2618	c.2483C>T	c.(2482-2484)ACT>ATT	p.T828I	GART_uc002yrz.2_Missense_Mutation_p.T828I|GART_uc010gmd.2_Missense_Mutation_p.T490I|GART_uc002yry.2_Missense_Mutation_p.T828I	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	828	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	TGGTTCCCGAGTACTGTCTAT	0.378													46	50					0	0	0	0	A	34878381	A	A	34878381	3	1	236	1	0	0	0	0	1	0	0	0	6278	1029	36	4	565	4	GART	21	34878381	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	2	34878381	13251514	536	43174	89	2									
DOPEY2	9980	broad.mit.edu	37	chr21	37652588	37652588	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctttaatatccagttggaAgtccattattgaccatcttt	10	18	5	8	0	2	1	0	1	2	0	4	2	4	2	3	1	0	1	3	1	4	8			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr21:37652588A>G	uc002yvg.2	+	31	6054	c.5975A>G	c.(5974-5976)AAG>AGG	p.K1992R	DOPEY2_uc011aeb.1_Missense_Mutation_p.K1941R	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1992					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TCCAGTTGGAAGTCCATTATT	0.289													8	27					0	0	0	0	G	37652588	G	G	37652588	3	3	236	1	0	0	0	0	1	0	0	0	4730	72	3	5	6093	5	DOPEY2	21	37652588	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	2774207	37652588	10477307	537	43175											
KCNJ15	3772	broad.mit.edu	37	chr21	39672100	39672100	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttatatcccagaggaaatctActggggttttgagtttgtgc	9	15	11	6	0	1	2	0	1	1	1	2	3	2	3	1	3	2	2	1	3	4	6	rs143222338	by1000genomes	TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr21:39672100A>T	uc002ywv.2	+	4	1219	c.917A>T	c.(916-918)TAC>TTC	p.Y306F	KCNJ15_uc002yww.2_Missense_Mutation_p.Y306F|KCNJ15_uc002ywx.2_Missense_Mutation_p.Y306F	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	306	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						GAGGAAATCTACTGGGGTTTT	0.468													23	13					0	0	0	0	T	39672100	T	T	39672100	3	4	236	1	0	0	0	0	1	0	0	0	8088	391	14	5	919	5	KCNJ15	21	39672100	Missense_Mutation	SNP	A	TCGA-CV-7245-01A-11D-2012-08	2019512	39672100	8457795	538	43176											
BRWD1	54014	broad.mit.edu	37	chr21	40578121	40578121	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtttttcattgaattttTgaccaattttaaaatcagaa	15	17	5	4	0	2	3	2	2	0	1	2	4	2	3	1	0	0	1	1	0	6	7			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr21:40578121T>C	uc002yxk.1	-	37	4416	c.4277A>G	c.(4276-4278)CAA>CGA	p.Q1426R	BRWD1_uc010goc.1_Missense_Mutation_p.Q69R|BRWD1_uc002yxl.2_Missense_Mutation_p.Q1426R|BRWD1_uc010god.1_Missense_Mutation_p.Q344R	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1426					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ATTGAATTTTTGACCAATTTT	0.318													62	30					0	0	0	0	C	40578121	C	C	40578121	3	2	236	1	0	0	0	0	1	0	0	0	1530	1812	63	5	2948	5	BRWD1	21	40578121	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	906021	40578121	7551774	539	43177											
IGSF5	150084	broad.mit.edu	37	chr21	41142930	41142930	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgtctaccctcacactggaCccggctcccggatatttcct	6	12	7	16	2	2	0	1	0	1	0	4	2	4	2	4	3	1	1	4	3	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr21:41142930C>A	uc002yyo.2	+	4	609	c.506C>A	c.(505-507)ACC>AAC	p.T169N		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	169	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				TCACACTGGACCCGGCTCCCG	0.483													31	20					3.99451e-17	7.67633e-17	1	0	A	41142930	A	A	41142930	3	1	236	1	0	0	0	0	1	0	0	0	7641	507	18	4	520	4	IGSF5	21	41142930	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	564809	41142930	6986965	540	43178											
CRYBB3	1417	broad.mit.edu	37	chr22	25601255	25601255	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccgcaagatggagatagtGgatgatgacgtgcccagcct	10	7	15	9	2	0	4	0	2	0	2	0	6	0	5	3	3	2	1	3	3	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr22:25601255G>A	uc003abo.1	+	5	468	c.396G>A	c.(394-396)GTG>GTA	p.V132V		NM_004076	NP_004067	P26998	CRBB3_HUMAN	crystallin, beta B3	132	Beta/gamma crystallin 'Greek key' 3.				visual perception		protein binding|structural constituent of eye lens				0						TGGAGATAGTGGATGATGACG	0.582													18	37					0	0	0	0	A	25601255	A	A	25601255	2	1	236	1	0	0	0	0	0	0	0	1	3927	1335	47	4		4	CRYBB3	22	25601255	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08		25601255	25703311	541	43179											
APOL6	80830	broad.mit.edu	37	chr22	36054987	36054987	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctggggtcaccagcatcGtgagtggtacgttggaacgc	8	8	15	10	3	1	1	1	1	0	0	2	2	1	2	1	4	4	4	1	4	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr22:36054987G>A	uc003aoe.2	+	3	670	c.376G>A	c.(376-378)GTG>ATG	p.V126M	APOL6_uc003aod.2_RNA	NM_030641	NP_085144	Q9BWW8	APOL6_HUMAN	apolipoprotein L6	126					lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity				0						CACCAGCATCGTGAGTGGTAC	0.577													11	51					0	0	0	0	A	36054987	A	A	36054987	3	1	236	1	0	0	0	0	1	0	0	0	810	1145	40	1	382	1	APOL6	22	36054987	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	10453732	36054987	15249579	542	43180											
TST	7263	broad.mit.edu	37	chr22	37407115	37407115	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacacggctctctgggggggCccggcgaaaccactcggacc	7	4	14	16	4	1	0	0	0	1	0	3	2	1	1	3	6	1	1	3	6	1	0			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr22:37407115C>G	uc003aqg.2	-	2	1547	c.847G>C	c.(847-849)GCC>CCC	p.A283P	TST_uc003aqh.2_Missense_Mutation_p.A283P	NM_003312	NP_003303	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase	283	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity				0						TCTGGGGGGGCCCGGCGAAAC	0.632													11	101					0	0	0	0	G	37407115	G	G	37407115	3	3	236	1	0	0	0	0	1	0	0	0	16740	739	26	4	50	4	TST	22	37407115	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1352128	37407115	13897451	543	43181											
CACNA1I	8911	broad.mit.edu	37	chr22	40055471	40055471	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catatttttggctgcaagttCagcctccgcacggacactgg	8	11	10	12	2	1	0	1	0	0	0	2	1	2	1	2	3	2	4	2	3	2	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr22:40055471C>A	uc003ayc.2	+	13	2364	c.2364C>A	c.(2362-2364)TTC>TTA	p.F788L	CACNA1I_uc003ayd.2_Missense_Mutation_p.F753L|CACNA1I_uc003aye.2_Missense_Mutation_p.F703L|CACNA1I_uc003ayf.2_Missense_Mutation_p.F668L	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	788	Extracellular (Potential).|II.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GCTGCAAGTTCAGCCTCCGCA	0.537													5	7					1.23904e-05	1.92522e-05	1	0	A	40055471	A	A	40055471	3	1	236	1	0	0	0	0	1	0	0	0	2558	825	29	2	2414	2	CACNA1I	22	40055471	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	2648356	40055471	11249095	544	43182											
MKL1	57591	broad.mit.edu	37	chr22	40815102	40815102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacggggggcgtggagcccGtgctgccaaacttcaccacc	8	5	13	15	3	1	0	1	0	0	0	1	1	1	1	4	4	4	1	4	4	1	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr22:40815102G>A	uc003ayv.1	-	9	1547	c.1340C>T	c.(1339-1341)ACG>ATG	p.T447M	MKL1_uc003ayw.1_Missense_Mutation_p.T447M|MKL1_uc010gye.1_Missense_Mutation_p.T447M|MKL1_uc010gyf.1_Missense_Mutation_p.T397M	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	447					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CGTGGAGCCCGTGCTGCCAAA	0.692			T	RBM15	acute megakaryocytic leukemia								9	14					0	0	0	0	A	40815102	A	A	40815102	3	1	236	1	0	0	0	0	1	0	0	0	9654	1145	40	1	1471	1	MKL1	22	40815102	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	759631	40815102	10489464	545	43183											
ACO2	50	broad.mit.edu	37	chr22	41922444	41922444	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggccccgtccctgacactgCccgctactacaaggtgggtc	6	8	11	16	2	0	1	0	1	0	0	2	1	1	1	4	3	3	1	4	3	3	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr22:41922444C>G	uc003bac.2	+	15	1962	c.1940C>G	c.(1939-1941)GCC>GGC	p.A647G	ACO2_uc003bad.2_Missense_Mutation_p.A672G|POLR3H_uc003bae.2_RNA|POLR3H_uc003baf.2_3'UTR|POLR3H_uc003bag.2_3'UTR|POLR3H_uc003bai.2_3'UTR	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	647					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						CCTGACACTGCCCGCTACTAC	0.577											OREG0026589	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	100					0	0	0	0	G	41922444	G	G	41922444	3	3	236	1	0	0	0	0	1	0	0	0	147	739	26	4	1998	4	ACO2	22	41922444	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1107342	41922444	9382122	546	43184											
SEPT3	55964	broad.mit.edu	37	chr22	42383671	42383671	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatgagcagtacgagaagttCctgaaggaggaggtcaacat	15	7	13	6	1	1	3	1	2	0	1	2	6	2	5	1	3	3	3	1	3	5	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr22:42383671C>T	uc003bbr.3	+	5	597	c.459C>T	c.(457-459)TTC>TTT	p.F153F	WBP2NL_uc011ape.1_Intron|SEPT3_uc003bbs.3_Silent_p.F153F|SEPT3_uc010gyr.2_Silent_p.F89F|SEPT3_uc011apj.1_Silent_p.F89F|SEPT3_uc010gys.2_5'UTR	NM_145733	NP_663786	Q9UH03	SEPT3_HUMAN	septin 3 isoform A	153					cell cycle|cytokinesis	cell junction|septin complex	GTP binding				0						ACGAGAAGTTCCTGAAGGAGG	0.507													18	44					0	0	0	0	T	42383671	T	T	42383671	2	4	236	1	0	0	0	0	0	0	0	1	14130	854	30	2		2	SEPT3	22	42383671	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	461227	42383671	8920895	547	43185											
CELSR1	9620	broad.mit.edu	37	chr22	46760459	46760459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagcctggctgcgcccccgCtctcctggtccggggggtac	3	7	14	17	3	1	0	0	0	1	0	3	0	2	0	5	5	3	3	5	5	2	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr22:46760459C>T	uc003bhw.1	-	33	8729	c.8729G>A	c.(8728-8730)AGC>AAC	p.S2910N		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2910	Cytoplasmic (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGCGCCCCCGCTCTCCTGGTC	0.692													50	15					0	0	0	0	T	46760459	T	T	46760459	3	4	236	1	0	0	0	0	1	0	0	0	3236	797	28	4	327	4	CELSR1	22	46760459	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4376788	46760459	4544107	548	43186											
ALG12	79087	broad.mit.edu	37	chr22	50307385	50307385	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccccagcagcaggggcCgcctgcctgatgaccccttt	6	6	12	17	1	0	2	0	2	0	0	0	2	0	2	7	2	4	3	7	2	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chr22:50307385C>A	uc003biy.2	-	2	303	c.29G>T	c.(28-30)CGG>CTG	p.R10L		NM_024105	NP_077010	Q9BV10	ALG12_HUMAN	alpha-1,6-mannosyltransferase ALG12	10					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane					0		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		BRCA - Breast invasive adenocarcinoma(115;0.199)|LUAD - Lung adenocarcinoma(64;0.247)		CAGCAGGGGCCGCCTGCCTGA	0.602													36	114					1.30998e-17	2.54733e-17	1	0	A	50307385	A	A	50307385	3	1	236	1	0	0	0	0	1	0	0	0	514	652	23	3	1473	3	ALG12	22	50307385	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3546926	50307385	997181	549	43187											
MAGEB4	4115	broad.mit.edu	37	chrX	30261232	30261232	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttgcagccaggcgtggcaCtacagccatgactagtgcgt	9	8	13	11	2	0	1	0	1	0	0	0	1	0	1	2	2	5	3	2	2	2	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:30261232C>T	uc004dcb.2	+	1	1064	c.980C>T	c.(979-981)ACT>ATT	p.T327I	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	327										ovary(1)	1						AGGCGTGGCACTACAGCCATG	0.517													14	69					0	0	0	0	T	30261232	T	T	30261232	3	4	236	1	0	0	0	0	1	0	0	0	9231	565	20	4	982	4	MAGEB4	23	30261232	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08		30261232	125009328	550	43188											
FAM120C	54954	broad.mit.edu	37	chrX	54209302	54209303	+	In_Frame_Ins	INS	-	GGCGGC	GGCGGC																															gggccccgggcagctgagggINSggcggcggcggcggcagcgg																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:54209302_54209303insGGCGGC	uc004dsz.3	-	1	412_413	c.329_330insGCCGCC	c.(328-330)CCC>CCGCCGCCC	p.110_110P>PPP	FAM120C_uc011moh.1_In_Frame_Ins_p.110_110P>PPP|FAM120C_uc004dta.2_In_Frame_Ins_p.110_110P>PPP	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	110										ovary(1)|central_nervous_system(1)	2						GCAGCTGAGGGGGCGGCGGCGG	0.748													---	---	---								GGCGGC	54209303	GGCGGC	GGCGGC	54209302	7	5	236	1	0	1	1	0	0	0	0	0	5446	1219	43	0	3046	0	FAM120C	23	54209302	In_Frame_Ins	INS	-	TCGA-CV-7245-01A-11D-2012-08	23948070	54209302	101061258	551	43189											
MSN	4478	broad.mit.edu	37	chrX	64959704	64959704	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatacaagaccctgcgccaGatccggcagggcaacaccaa	15	3	9	14	2	0	2	0	0	0	2	1	2	1	2	4	2	3	2	4	2	5	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:64959704G>T	uc004dwf.2	+	13	1881	c.1683G>T	c.(1681-1683)CAG>CAT	p.Q561H		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	561					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						CCCTGCGCCAGATCCGGCAGG	0.547			T	ALK	ALCL								24	27					1.1804e-14	2.2079e-14	1	0	T	64959704	T	T	64959704	3	4	236	1	0	0	0	0	1	0	0	0	9938	933	33	2	1733	2	MSN	23	64959704	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	10750402	64959704	90310856	552	43190											
RAB41	347517	broad.mit.edu	37	chrX	69502178	69502178	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaatctaaactcttattcctGggagagcagagcggtgtggg	11	10	13	7	1	2	2	0	0	2	2	3	3	3	2	1	3	3	1	1	3	4	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:69502178G>T	uc004dyc.2	+	1	111	c.111G>T	c.(109-111)CTG>CTT	p.L37L	RAB41_uc010nkv.2_Silent_p.L27L	NM_001032726	NP_001027898	Q5JT25	RAB41_HUMAN	RAB41, member RAS oncogene family	37					protein transport|small GTPase mediated signal transduction		GTP binding			ovary(2)|breast(2)	4						TCTTATTCCTGGGAGAGCAGA	0.557													13	9					9.05144e-12	1.59865e-11	1	0	T	69502178	T	T	69502178	2	4	236	1	0	0	0	0	0	0	0	1	13008	1335	47	4		4	RAB41	23	69502178	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	4542474	69502178	85768382	553	43191											
LPAR4	2846	broad.mit.edu	37	chrX	78011270	78011270	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccttgtgccttgcaactCtgaactgttgttttgaccct	6	16	7	12	0	2	2	1	2	1	0	2	2	2	2	3	0	4	3	3	0	2	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:78011270C>A	uc010nme.2	+	2	1309	c.904C>A	c.(904-906)CTG>ATG	p.L302M		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	302	Helical; Name=7; (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						CCTTGCAACTCTGAACTGTTG	0.423													22	11					8.10497e-08	1.33766e-07	1	0	A	78011270	A	A	78011270	3	1	236	1	0	0	0	0	1	0	0	0	8957	912	32	2	906	2	LPAR4	23	78011270	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	8509092	78011270	77259290	554	43192											
CPXCR1	53336	broad.mit.edu	37	chrX	88009299	88009299	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgaattaagacaacattCatgcagctcttctgggaatt	12	13	7	9	0	4	2	1	1	3	1	4	3	4	3	0	1	3	2	0	1	4	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:88009299C>A	uc004efd.3	+	3	1143	c.884C>A	c.(883-885)TCA>TAA	p.S295*	CPXCR1_uc004efc.3_Nonsense_Mutation_p.S295*	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	295						intracellular	zinc ion binding			ovary(3)	3						AGACAACATTCATGCAGCTCT	0.299													16	2					1.99824e-07	3.265e-07	1	0	A	88009299	A	A	88009299	4	1	236	1	0	0	0	0	0	1	0	0	3851	838	29	2	886	2	CPXCR1	23	88009299	Nonsense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	9998029	88009299	67261261	555	43193											
DIAPH2	1730	broad.mit.edu	37	chrX	96396710	96396710	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaaacaacccttttgcattTtattgccgacatttgtgagg	12	14	7	8	1	0	1	0	1	0	0	0	2	0	1	2	1	4	1	2	1	4	6			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:96396710T>C	uc004efu.3	+	22	3032	c.2636T>C	c.(2635-2637)TTT>TCT	p.F879S	DIAPH2_uc004eft.3_Missense_Mutation_p.F879S	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	879	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						CTTTTGCATTTTATTGCCGAC	0.308													12	21					0	0	0	0	C	96396710	C	C	96396710	3	2	236	1	0	0	0	0	1	0	0	0	4541	1841	64	5	2722	5	DIAPH2	23	96396710	Missense_Mutation	SNP	T	TCGA-CV-7245-01A-11D-2012-08	8387411	96396710	58873850	556	43194											
PCDH19	57526	broad.mit.edu	37	chrX	99551562	99551562	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctcacagccattgcctgcctCccggataacgctgttgacct	7	10	8	16	2	1	1	1	1	0	0	2	2	2	2	5	1	4	2	5	1	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:99551562C>G	uc010nmz.2	-	6	4836	c.3160G>C	c.(3160-3162)GAG>CAG	p.E1054Q	PCDH19_uc004efw.3_Missense_Mutation_p.E1006Q|PCDH19_uc004efx.3_Missense_Mutation_p.E1007Q	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	1054	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						TTGCCTGCCTCCCGGATAACG	0.597													32	31					0	0	0	0	G	99551562	G	G	99551562	3	3	236	1	0	0	0	0	1	0	0	0	11568	864	30	2	290	2	PCDH19	23	99551562	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	3154852	99551562	55718998	557	43195											
PCDH19	57526	broad.mit.edu	37	chrX	99551615	99551615	+	Frame_Shift_Del	DEL	T	-	-																															tggtcacatcgacagtcctcTtgcctttcagggtaggcctc																										TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:99551615delT	uc010nmz.2	-	6	4783	c.3107delA	c.(3106-3108)AAGfs	p.K1036fs	PCDH19_uc004efw.3_Frame_Shift_Del_p.K988fs|PCDH19_uc004efx.3_Frame_Shift_Del_p.K989fs	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	1036	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GACAGTCCTCTTGCCTTTCAG	0.597													---	---	---								-	99551615	-	-	99551615	7	5	236	1	0	1	0	1	0	0	0	0	11568	1609	56	0	343	0	PCDH19	23	99551615	Frame_Shift_Del	DEL	T	TCGA-CV-7245-01A-11D-2012-08	53	99551615	55718945	558	43196											
IRS4	8471	broad.mit.edu	37	chrX	107978532	107978532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagggttaacaggtgggcgCcgatgctgatgctgtagctg	7	9	17	8	2	0	1	0	1	0	0	0	2	0	1	1	3	4	6	1	3	2	2			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:107978532C>T	uc004eoc.2	-	1	1076	c.1043G>A	c.(1042-1044)GGC>GAC	p.G348D		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	348						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CAGGTGGGCGCCGATGCTGAT	0.592													76	185					0	0	0	0	T	107978532	T	T	107978532	3	4	236	1	0	0	0	0	1	0	0	0	7881	739	26	4	2734	4	IRS4	23	107978532	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	8426917	107978532	47292028	559	43197											
AMOT	154796	broad.mit.edu	37	chrX	112054479	112054479	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgttggttccctcacctCtcagatccctgttgaaatca	7	14	7	13	0	4	2	3	1	2	1	7	2	6	2	3	1	0	3	3	1	1	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:112054479C>A	uc004epr.2	-	3	1535	c.1535G>T	c.(1534-1536)AGA>ATA	p.R512I	AMOT_uc004eps.2_Missense_Mutation_p.R103I|AMOT_uc004ept.1_Missense_Mutation_p.R512I	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	512	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						TCCCTCACCTCTCAGATCCCT	0.512													86	77					6.11831e-30	1.27023e-29	1	0	A	112054479	A	A	112054479	3	1	236	1	0	0	0	0	1	0	0	0	582	913	32	2	1755	2	AMOT	23	112054479	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	4075947	112054479	43216081	560	43198											
ODZ1	10178	broad.mit.edu	37	chrX	123615699	123615699	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaaattcttggacagatCtttcgtctccacaagagatt	12	14	6	9	1	4	2	1	0	3	2	6	4	4	3	1	1	0	0	1	1	3	5			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:123615699C>A	uc004euj.2	-	21	3875	c.3811G>T	c.(3811-3813)GAT>TAT	p.D1271Y	ODZ1_uc011muj.1_Missense_Mutation_p.D1277Y|ODZ1_uc010nqy.2_Missense_Mutation_p.D1278Y	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1271	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTGGACAGATCTTTCGTCTCC	0.458													53	44					2.43277e-16	4.64782e-16	1	0	A	123615699	A	A	123615699	3	1	236	1	0	0	0	0	1	0	0	0	10888	913	32	2	4410	2	ODZ1	23	123615699	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	11561220	123615699	31654861	561	43199											
DCAF12L2	340578	broad.mit.edu	37	chrX	125299776	125299776	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcctgcgacgcgtcgccggCcgcttctgcttcttgggtag	3	10	14	14	6	2	0	0	0	2	0	3	1	2	0	3	2	3	3	3	2	1	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:125299776C>T	uc004euk.1	-	1	159	c.132G>A	c.(130-132)CGG>CGA	p.R44R		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	44										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GCGTCGCCGGCCGCTTCTGCT	0.731													44	3					0	0	0	0	T	125299776	T	T	125299776	2	4	236	1	0	0	0	0	0	0	0	1	4282	726	26	4		4	DCAF12L2	23	125299776	Silent	SNP	C	TCGA-CV-7245-01A-11D-2012-08	1684077	125299776	29970784	562	43200											
SASH3	54440	broad.mit.edu	37	chrX	128926745	128926745	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcatgcccgccccagccgccGacagagcaagggcaagaggc	10	1	14	16	3	0	2	0	0	0	2	0	3	0	2	5	2	3	3	5	2	2	0	rs35096611	byFrequency	TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:128926745G>C	uc011mun.1	+	6	916	c.734G>C	c.(733-735)CGA>CCA	p.R245P	SASH3_uc004euu.2_Missense_Mutation_p.R245P|SASH3_uc011muo.1_Missense_Mutation_p.R212P	NM_018990	NP_061863	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	245										ovary(2)|pancreas(1)	3						CCCAGCCGCCGACAGAGCAAG	0.597													51	9					0	0	0	0	C	128926745	C	C	128926745	3	2	236	1	0	0	0	0	1	0	0	0	13914	1058	37	3	756	3	SASH3	23	128926745	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	3626969	128926745	26343815	563	43201											
BCORL1	63035	broad.mit.edu	37	chrX	129149304	129149304	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttccagtgccgggcagctGacccccagtcagggggcgcc	6	6	14	15	2	1	1	1	1	0	0	2	1	2	1	5	3	2	2	5	3	0	1			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:129149304G>T	uc004evb.1	+	4	2670	c.2556G>T	c.(2554-2556)CTG>CTT	p.L852L	BCORL1_uc010nrd.1_Silent_p.L754L	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	852					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CCGGGCAGCTGACCCCCAGTC	0.617													83	27					2.13431e-38	4.47839e-38	1	0	T	129149304	T	T	129149304	2	4	236	1	0	0	0	0	0	0	0	1	1389	1277	45	2		2	BCORL1	23	129149304	Silent	SNP	G	TCGA-CV-7245-01A-11D-2012-08	222559	129149304	26121256	564	43202											
SLITRK4	139065	broad.mit.edu	37	chrX	142716919	142716919	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttttgtggtcatgcttcCttagctgcagctgcatggag	5	15	13	8	0	1	0	1	0	0	0	2	1	2	1	1	3	5	6	1	3	1	4			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:142716919C>T	uc004fbx.2	-	2	2382	c.2006G>A	c.(2005-2007)AGG>AAG	p.R669K	SLITRK4_uc004fby.2_Missense_Mutation_p.R669K	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	669	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GTCATGCTTCCTTAGCTGCAG	0.473													40	138					0	0	0	0	T	142716919	T	T	142716919	3	4	236	1	0	0	0	0	1	0	0	0	14809	681	24	4	511	4	SLITRK4	23	142716919	Missense_Mutation	SNP	C	TCGA-CV-7245-01A-11D-2012-08	13567615	142716919	12553641	565	43203											
CNGA2	1260	broad.mit.edu	37	chrX	150912139	150912139	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcagagttccaggctaaGatcgatgccgtgaaacacta	12	7	12	10	3	0	3	0	1	0	2	2	4	1	3	2	2	2	3	2	2	3	3			TCGA-CV-7245-01A-11D-2012-08	TCGA-CV-7245-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	56291b3c-595c-4388-a264-9037a48401d8	081cec95-360f-4127-9fbc-e6bfd212c23f	g.chrX:150912139G>T	uc004fey.1	+	7	1388	c.1164G>T	c.(1162-1164)AAG>AAT	p.K388N		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	388	Extracellular (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGGCTAAGATCGATGCCG	0.502													17	77					1.5739e-10	2.74523e-10	1	0	T	150912139	T	T	150912139	3	4	236	1	0	0	0	0	1	0	0	0	3612	933	33	2	1186	2	CNGA2	23	150912139	Missense_Mutation	SNP	G	TCGA-CV-7245-01A-11D-2012-08	8195220	150912139	4358421	566	43204											
CDK11B	984	broad.mit.edu	37	chr1	1573143	1573143	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctctaacggtgacgatgttgGgatgctgggccttgaggatg	7	11	16	7	2	1	2	0	2	1	0	1	5	1	4	1	4	2	2	1	4	1	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:1573143G>T	uc001agv.1	-	17	1556	c.1445C>A	c.(1444-1446)CCC>CAC	p.P482H	CDK11B_uc009vkj.2_Missense_Mutation_p.P139H|CDK11B_uc001ags.1_Missense_Mutation_p.P340H|CDK11B_uc001agt.1_Missense_Mutation_p.P265H|CDK11B_uc001aha.1_Missense_Mutation_p.P448H|CDK11B_uc001agw.1_Missense_Mutation_p.P437H|CDK11B_uc001agy.1_Missense_Mutation_p.P480H|CDK11B_uc001agx.1_Missense_Mutation_p.P471H|CDK11B_uc001agz.1_Missense_Mutation_p.P226H	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	495	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						GACGATGTTGGGATGCTGGGC	0.607													21	222					1.28384e-07	5.78433e-07	1	0	T	1573143	T	T	1573143	3	4	237	1	0	0	0	0	1	0	0	0	3142	1232	43	4	935	4	CDK11B	1	1573143	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08		1573143	247677478	1	43205											
ARHGEF16	27237	broad.mit.edu	37	chr1	3397090	3397090	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccgcttcatcaccagccGtgtggccgtggagggcaatg	6	8	14	13	3	2	0	2	0	0	0	2	1	2	1	4	3	2	2	4	3	1	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:3397090G>A	uc001akg.3	+	15	2317	c.2069G>A	c.(2068-2070)CGT>CAT	p.R690H	ARHGEF16_uc001aki.2_Missense_Mutation_p.R402H|ARHGEF16_uc001akj.2_Missense_Mutation_p.R402H|ARHGEF16_uc010nzh.1_Missense_Mutation_p.R394H	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	690					activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		ATCACCAGCCGTGTGGCCGTG	0.677													6	49					0	0	0	0	A	3397090	A	A	3397090	3	1	237	1	0	0	0	0	1	0	0	0	899	1145	40	1	2123	1	ARHGEF16	1	3397090	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	1823947	3397090	245853531	2	43206											
NBL1	4681	broad.mit.edu	37	chr1	19969685	19969685	+	5'Flank	DEL	C	-	-																															gaaaggaggggaagggaattCcgggcagagggaagggcgca																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:19969685delC	uc001bck.1	+						NBL1_uc009vpl.1_Intron|NBL1_uc001bcj.1_5'Flank|NBL1_uc009vpm.1_5'Flank	NM_005380	NP_005371	P41271	NBL1_HUMAN	neuroblastoma, suppression of tumorigenicity 1 2							extracellular region				ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00043)|Ovarian(437;0.00373)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.9e-05)|Kidney(64;0.000173)|GBM - Glioblastoma multiforme(114;0.0012)|KIRC - Kidney renal clear cell carcinoma(64;0.0026)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		gaagggaattccgggcagagg	0.06													---	---	---								-	19969685	-	-	19969685	6	5	237	0	1	1	0	1	0	0	0	0	10243	870	30	0		0	NBL1	1	19969685	5'Flank	DEL	C	TCGA-CV-7247-01A-11D-2012-08	16572595	19969685	229280936	3	43207											
MAN1C1	57134	broad.mit.edu	37	chr1	25944781	25944781	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacgagggccgatgagagtCaggagccccagagccaagtg	12	3	16	10	2	1	2	1	1	0	2	1	7	1	3	4	2	3	0	4	2	2	0			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:25944781C>T	uc001bkm.2	+	1	823	c.493C>T	c.(493-495)CAG>TAG	p.Q165*	MAN1C1_uc009vry.1_5'UTR	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	165	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		CGATGAGAGTCAGGAGCCCCA	0.637													5	12					0	0	0	0	T	25944781	T	T	25944781	4	4	237	1	0	0	0	0	0	1	0	0	9266	827	29	2	495	2	MAN1C1	1	25944781	Nonsense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	5975096	25944781	223305840	4	43208											
C1orf177	163747	broad.mit.edu	37	chr1	55279519	55279519	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggaactgatgaatttcaaGagctttgtagaagaacttaa	16	11	10	4	0	1	5	1	2	0	3	1	6	1	6	0	1	3	2	0	1	7	4			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:55279519G>T	uc001cyb.3	+	7	849	c.795G>T	c.(793-795)AAG>AAT	p.K265N	C1orf177_uc001cya.3_Missense_Mutation_p.K265N	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	265											0						TGAATTTCAAGAGCTTTGTAG	0.413													6	60					0.00116845	0.00483902	1	0	T	55279519	T	T	55279519	3	4	237	1	0	0	0	0	1	0	0	0	2026	933	33	2	821	2	C1orf177	1	55279519	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	29334738	55279519	193971102	5	43209											
PRKAA2	5563	broad.mit.edu	37	chr1	57140142	57140142	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttagatgttgttggaaaaatAaaacgagaaattcaaaatct	19	12	7	3	1	2	2	1	0	1	2	2	4	2	3	0	1	1	2	0	1	8	5			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:57140142A>C	uc001cyk.3	+	2	254	c.183A>C	c.(181-183)ATA>ATC	p.I61I		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	61	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						TTGGAAAAATAAAACGAGAAA	0.294													18	62					0	0	0	0	C	57140142	C	C	57140142	2	2	237	1	0	0	0	0	0	0	0	1	12556	352	13	5		5	PRKAA2	1	57140142	Silent	SNP	A	TCGA-CV-7247-01A-11D-2012-08	1860623	57140142	192110479	6	43210											
USP33	23032	broad.mit.edu	37	chr1	78194375	78194375	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgaagcaaatccattaaaCatcgaaggaattcttgagca	17	9	7	8	1	1	2	0	2	1	0	3	4	2	3	1	1	3	2	1	1	6	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:78194375C>T	uc001dht.2	-	11	1180	c.833G>A	c.(832-834)TGT>TAT	p.C278Y	USP33_uc001dhs.2_5'UTR|USP33_uc001dhu.2_Missense_Mutation_p.C247Y|USP33_uc001dhv.2_Missense_Mutation_p.C83Y|USP33_uc001dhw.2_Missense_Mutation_p.C278Y	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	278					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						ATCCATTAAACATCGAAGGAA	0.353													28	50					0	0	0	0	T	78194375	T	T	78194375	3	4	237	1	0	0	0	0	1	0	0	0	17132	478	17	4	2067	4	USP33	1	78194375	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	21054233	78194375	171056246	7	43211											
FLG	2312	broad.mit.edu	37	chr1	152283083	152283083	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcccctgactggccacgtgCggactctttgtggctctgct	3	13	11	14	2	2	1	0	1	2	0	3	2	3	2	3	3	2	2	3	3	0	2	rs148844389	byFrequency	TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:152283083C>T	uc001ezu.1	-	3	4315	c.4279G>A	c.(4279-4281)GCA>ACA	p.A1427T	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1427	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCCACGTGCGGACTCTTTG	0.557									Ichthyosis				38	318					0	0	0	0	T	152283083	T	T	152283083	3	4	237	1	0	0	0	0	1	0	0	0	5954	768	27	1	7910	1	FLG	1	152283083	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	74088708	152283083	96967538	8	43212											
PPOX	5498	broad.mit.edu	37	chr1	161140306	161140306	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcccccctggcctcagagtGactgtgaggaggaggaaact	10	6	14	11	0	1	3	1	2	0	1	1	6	1	6	4	4	2	0	4	4	1	0			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:161140306G>A	uc001fyj.2	+	10	1385	c.1095G>A	c.(1093-1095)GTG>GTA	p.V365V	PPOX_uc001fyn.2_Intron|PPOX_uc001fyg.2_Silent_p.V365V|PPOX_uc001fyl.2_Silent_p.V331V|PPOX_uc001fym.2_RNA|PPOX_uc001fyk.2_Silent_p.V203V|PPOX_uc001fyh.2_Silent_p.V203V|PPOX_uc010pkg.1_Silent_p.V203V|PPOX_uc009wuc.1_Intron|PPOX_uc010pkh.1_Silent_p.V110V|PPOX_uc001fyi.2_Silent_p.V203V	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	365					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GCCTCAGAGTGACTGTGAGGA	0.542									Porphyria_Variegata				10	66					0	0	0	0	A	161140306	A	A	161140306	2	1	237	1	0	0	0	0	0	0	0	1	12408	1277	45	2		2	PPOX	1	161140306	Silent	SNP	G	TCGA-CV-7247-01A-11D-2012-08	8857223	161140306	88110315	9	43213											
PAPPA2	60676	broad.mit.edu	37	chr1	176563958	176563958	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atggcatcttgccgctctttGctcctggggggagacagctc	5	11	13	12	1	2	1	0	0	2	1	4	2	3	1	2	4	3	4	2	4	0	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:176563958G>T	uc001gkz.2	+	3	2382	c.1218G>T	c.(1216-1218)TTG>TTT	p.L406F	PAPPA2_uc001gky.1_Missense_Mutation_p.L406F|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	406					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCCGCTCTTTGCTCCTGGGGG	0.587													32	59					4.3181e-19	2.10764e-18	1	0	T	176563958	T	T	176563958	3	4	237	1	0	0	0	0	1	0	0	0	11487	1310	46	4	1224	4	PAPPA2	1	176563958	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	15423652	176563958	72686663	10	43214											
USH2A	7399	broad.mit.edu	37	chr1	216380633	216380633	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgtatgggtattgatcctCtgttgtgtagatttcaaaac	10	16	9	6	0	2	2	1	1	1	1	3	2	3	2	1	1	1	4	1	1	5	6			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:216380633C>G	uc001hku.1	-	16	3685	c.3298G>C	c.(3298-3300)GAG>CAG	p.E1100Q	USH2A_uc001hkv.2_Missense_Mutation_p.E1100Q	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1100	Extracellular (Potential).|Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TATTGATCCTCTGTTGTGTAG	0.373										HNSCC(13;0.011)			9	48					0	0	0	0	G	216380633	G	G	216380633	3	3	237	1	0	0	0	0	1	0	0	0	17104	922	32	2	12552	2	USH2A	1	216380633	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	39816675	216380633	32869988	11	43215											
HEATR1	55127	broad.mit.edu	37	chr1	236760193	236760193	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgatacgtcctctgcagcTaccagcgccgacactatggt	8	10	9	14	3	2	1	0	1	2	0	3	2	3	1	3	1	5	2	3	1	3	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:236760193T>C	uc001hyd.1	-	6	812	c.687A>G	c.(685-687)GTA>GTG	p.V229V		NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	229					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CCTCTGCAGCTACCAGCGCCG	0.448													10	80					0	0	0	0	C	236760193	C	C	236760193	2	2	237	1	0	0	0	0	0	0	0	1	7066	1509	53	5		5	HEATR1	1	236760193	Silent	SNP	T	TCGA-CV-7247-01A-11D-2012-08	20379560	236760193	12490428	12	43216											
OR14A16	284532	broad.mit.edu	37	chr1	247978414	247978414	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgatgacaataaaacagcaGaaatccaaaactacattaat	22	8	4	7	0	0	3	0	2	0	1	1	3	1	3	1	0	4	1	1	0	8	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:247978414G>A	uc001idm.1	-	1	618	c.618C>T	c.(616-618)TTC>TTT	p.F206F		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TAAAACAGCAGAAATCCAAAA	0.373													4	50					0	0	0	0	A	247978414	A	A	247978414	2	1	237	1	0	0	0	0	0	0	0	1	10999	933	33	2		2	OR14A16	1	247978414	Silent	SNP	G	TCGA-CV-7247-01A-11D-2012-08	11218221	247978414	1272207	13	43217											
OR2T27	403239	broad.mit.edu	37	chr1	248814121	248814121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaagagaagccaggggaaaCgggcgttgctgaacaaaccc	15	3	13	10	2	0	2	0	1	0	1	0	4	0	3	2	3	5	2	2	3	5	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr1:248814121C>T	uc010pzo.1	-	1	65	c.65G>A	c.(64-66)CGT>CAT	p.R22H		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCAGGGGAAACGGGCGTTGCT	0.483													13	86					0	0	0	0	T	248814121	T	T	248814121	3	4	237	1	0	0	0	0	1	0	0	0	11075	536	19	1	891	1	OR2T27	1	248814121	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	835707	248814121	436500	14	43218											
HEATR5B	54497	broad.mit.edu	37	chr2	37284598	37284598	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagtgaattccgctaccagTtctctaagaagtgcattaaa	15	11	7	8	1	1	2	0	1	1	1	3	2	2	2	2	0	2	3	2	0	7	5			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:37284598T>G	uc002rpp.1	-	15	2181	c.2085A>C	c.(2083-2085)GAA>GAC	p.E695D		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	695							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				CCGCTACCAGTTCTCTAAGAA	0.363													6	23					0	0	0	0	G	37284598	G	G	37284598	3	3	237	1	0	0	0	0	1	0	0	0	7071	1722	60	5	4218	5	HEATR5B	2	37284598	Missense_Mutation	SNP	T	TCGA-CV-7247-01A-11D-2012-08		37284598	205914775	15	43219											
QPCT	25797	broad.mit.edu	37	chr2	37599902	37599902	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgacaatgaagaaaatttgGatgaatcaaccattgacaat	19	10	7	5	0	1	5	1	4	0	1	1	6	1	6	1	1	1	0	1	1	7	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:37599902G>A	uc002rqg.2	+	7	1140	c.1018G>A	c.(1018-1020)GAT>AAT	p.D340N	QPCT_uc002rqh.2_Missense_Mutation_p.D291N	NM_012413	NP_036545	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase precursor	340					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)	1		Ovarian(717;0.051)|all_hematologic(82;0.21)				AGAAAATTTGGATGAATCAAC	0.358													4	75					0	0	0	0	A	37599902	A	A	37599902	3	1	237	1	0	0	0	0	1	0	0	0	12939	1174	41	2	1044	2	QPCT	2	37599902	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	315304	37599902	205599471	16	43220											
CTNNA2	1496	broad.mit.edu	37	chr2	80816531	80816531	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgcagaagtggccaaaTgggacgacagcggcaatgat	13	6	15	7	2	0	2	0	1	0	1	0	5	0	4	1	4	2	2	1	4	3	0			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:80816531T>G	uc010ysh.1	+	14	2115	c.2110T>G	c.(2110-2112)TGG>GGG	p.W704G	CTNNA2_uc010yse.1_Missense_Mutation_p.W704G|CTNNA2_uc010ysf.1_Missense_Mutation_p.W704G|CTNNA2_uc010ysg.1_Missense_Mutation_p.W704G|CTNNA2_uc010ysi.1_Missense_Mutation_p.W336G|CTNNA2_uc010ysj.1_Missense_Mutation_p.W33G	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	704					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AGTGGCCAAATGGGACGACAG	0.498													9	81					0	0	0	0	G	80816531	G	G	80816531	3	3	237	1	0	0	0	0	1	0	0	0	4030	1464	51	5	1956	5	CTNNA2	2	80816531	Missense_Mutation	SNP	T	TCGA-CV-7247-01A-11D-2012-08	43216629	80816531	162382842	17	43221											
ZRANB3	84083	broad.mit.edu	37	chr2	135965229	135965229	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaccgtgaatcccaagagttCgctttacatgcttgcttagt	10	13	8	10	2	0	2	0	1	0	1	2	2	1	2	2	0	4	4	2	0	5	5			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:135965229C>T	uc002tum.2	-	19	2901	c.2784G>A	c.(2782-2784)GCG>GCA	p.A928A	ZRANB3_uc002tuk.2_Silent_p.A471A|ZRANB3_uc002tul.2_Silent_p.A926A	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	928						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		CCCAAGAGTTCGCTTTACATG	0.428													28	194					0	0	0	0	T	135965229	T	T	135965229	2	4	237	1	0	0	0	0	0	0	0	1	18291	871	31	1		1	ZRANB3	2	135965229	Silent	SNP	C	TCGA-CV-7247-01A-11D-2012-08	55148698	135965229	107234144	18	43222											
STK39	27347	broad.mit.edu	37	chr2	169020294	169020294	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatagtctaagccttccaaaAcctctttaagaattgttgct	12	14	6	9	0	2	1	0	0	2	1	3	2	3	1	3	0	3	2	3	0	6	7			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:169020294A>C	uc002uea.2	-	4	687	c.527T>G	c.(526-528)GTT>GGT	p.V176G		NM_013233	NP_037365	Q9UEW8	STK39_HUMAN	serine threonine kinase 39 (STE20/SPS1 homolog,	176	Protein kinase.				response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2						GCCTTCCAAAACCTCTTTAAG	0.363													5	50					0	0	0	0	C	169020294	C	C	169020294	3	2	237	1	0	0	0	0	1	0	0	0	15371	43	2	5	1170	5	STK39	2	169020294	Missense_Mutation	SNP	A	TCGA-CV-7247-01A-11D-2012-08	33055065	169020294	74179079	19	43223											
CERKL	375298	broad.mit.edu	37	chr2	182414397	182414397	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgttgcagttatcacatgagGaactccatgaagagaatgtg	13	11	11	6	0	1	3	1	2	0	1	2	5	2	4	1	1	2	3	1	1	4	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr2:182414397G>A	uc002unx.2	-	7	1038	c.937C>T	c.(937-939)CCT>TCT	p.P313S	CERKL_uc002uny.2_Missense_Mutation_p.P287S|CERKL_uc010zfm.1_Missense_Mutation_p.P269S|CERKL_uc002unz.2_Missense_Mutation_p.P35S|CERKL_uc002uoa.2_Missense_Mutation_p.P218S|CERKL_uc002uob.2_Missense_Mutation_p.P35S|CERKL_uc002uoc.2_Missense_Mutation_p.P174S|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_Missense_Mutation_p.P82S|CERKL_uc002uoe.2_Missense_Mutation_p.P287S|CERKL_uc002unw.2_5'Flank	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	313	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ATCACATGAGGAACTCCATGA	0.343													11	80					0	0	0	0	A	182414397	A	A	182414397	3	1	237	1	0	0	0	0	1	0	0	0	3283	1174	41	2	771	2	CERKL	2	182414397	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	13394103	182414397	60784976	20	43224											
KIAA2018	205717	broad.mit.edu	37	chr3	113378750	113378750	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccaggaggtggagcagggagGagtggcaaaggattctgatt	11	7	18	5	0	1	1	0	1	1	0	1	6	1	6	1	7	1	2	1	7	1	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:113378750G>C	uc003eam.2	-	7	2190	c.1779C>G	c.(1777-1779)CTC>CTG	p.L593L	KIAA2018_uc003eal.2_Silent_p.L537L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	593					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GAGCAGGGAGGAGTGGCAAAG	0.473													30	67					0	0	0	0	C	113378750	C	C	113378750	2	2	237	1	0	0	0	0	0	0	0	1	8307	1161	41	2		2	KIAA2018	3	113378750	Silent	SNP	G	TCGA-CV-7247-01A-11D-2012-08		113378750	84643680	21	43225											
SRPRB	58477	broad.mit.edu	37	chr3	133538447	133538447	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccagcacactggacagttCcagcactgcccctgctcagc	8	6	8	19	0	1	0	1	0	0	0	2	1	2	1	5	1	5	4	5	1	0	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:133538447C>A	uc003epx.1	+	7	669	c.653C>A	c.(652-654)TCC>TAC	p.S218Y		NM_021203	NP_067026	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, beta	218						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			ovary(1)	1						CTGGACAGTTCCAGCACTGCC	0.517													7	71					0.000673444	0.00284652	1	0	A	133538447	A	A	133538447	3	1	237	1	0	0	0	0	1	0	0	0	15229	855	30	2	679	2	SRPRB	3	133538447	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	20159697	133538447	64483983	22	43226											
CLSTN2	64084	broad.mit.edu	37	chr3	140167413	140167413	+	Frame_Shift_Del	DEL	C	-	-																															tccgggagcatgcccctgttCcccagcatccacctggagac																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:140167413delC	uc003etn.2	+	6	1030	c.840delC	c.(838-840)TTCfs	p.F280fs	CLSTN2_uc003etm.2_Frame_Shift_Del_p.F280fs	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	280	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TGCCCCTGTTCCCCAGCATCC	0.512										HNSCC(16;0.037)			---	---	---								-	140167413	-	-	140167413	7	5	237	1	0	1	0	1	0	0	0	0	3577	854	30	0	862	0	CLSTN2	3	140167413	Frame_Shift_Del	DEL	C	TCGA-CV-7247-01A-11D-2012-08	6628966	140167413	57855017	23	43227											
HTR3D	200909	broad.mit.edu	37	chr3	183754191	183754191	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agacacctgcaggtctcatgGctagtatgtcaatagtgaag	12	10	11	8	0	2	2	2	1	1	1	3	2	2	2	1	2	1	3	1	2	5	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:183754191G>T	uc011bqv.1	+	4	409	c.409G>T	c.(409-411)GCT>TCT	p.A137S	HTR3D_uc003fmj.2_Missense_Mutation_p.A2S|HTR3D_uc011bqu.1_Missense_Mutation_p.A76S|HTR3D_uc010hxp.2_Intron	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	137	Extracellular (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGGTCTCATGGCTAGTATGTC	0.507													16	23					4.14922e-12	1.97812e-11	1	0	T	183754191	T	T	183754191	3	4	237	1	0	0	0	0	1	0	0	0	7486	1203	42	4	520	4	HTR3D	3	183754191	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	43586778	183754191	14268239	24	43228											
PYDC2	152138	broad.mit.edu	37	chr3	191179054	191179054	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgatcagaacaatctccCtgggaaaggagctacagacc	13	7	9	12	0	3	3	1	1	2	2	4	5	3	5	2	2	3	1	2	2	4	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:191179054C>A	uc011bso.1	+	1	103	c.103C>A	c.(103-105)CTG>ATG	p.L35M		NM_001083308	NP_001076777	Q56P42	PYDC2_HUMAN	pyrin domain containing 2	35	DAPIN.					cytoplasm|nucleus					0						AACAATCTCCCTGGGAAAGGA	0.537													10	96					7.48243e-07	3.33456e-06	1	0	A	191179054	A	A	191179054	3	1	237	1	0	0	0	0	1	0	0	0	12924	680	24	4	105	4	PYDC2	3	191179054	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	7424863	191179054	6843376	25	43229											
MUC20	200958	broad.mit.edu	37	chr3	195447901	195447901	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgtctctggggtctggCtctgccccttttcttcttct	0	17	11	13	0	6	0	0	0	6	0	7	0	6	0	2	4	1	2	2	4	0	4			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr3:195447901C>G	uc010hzo.2	+	1	149	c.23C>G	c.(22-24)GCT>GGT	p.A8G		NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	8					protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		TGGGGTCTGGCTCTGCCCCTT	0.617													2	7					0	0	0	0	G	195447901	G	G	195447901	3	3	237	1	0	0	0	0	1	0	0	0	10029	797	28	4	25	4	MUC20	3	195447901	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	4268847	195447901	2574529	26	43230											
SLC26A1	10861	broad.mit.edu	37	chr4	985266	985266	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgatgccgatgaccagccCagacatgacgtcgcctgcca	10	6	11	14	3	0	4	0	3	0	1	1	6	0	4	5	0	3	0	5	0	0	0			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr4:985266C>A	uc003gcb.2	-	3	604	c.226G>T	c.(226-228)GGG>TGG	p.G76W	SLC26A1_uc003gbx.2_Missense_Mutation_p.G76W|IDUA_uc003gby.2_Intron|IDUA_uc003gbz.2_Intron|IDUA_uc003gca.2_Intron|SLC26A1_uc003gcc.2_Missense_Mutation_p.G76W	NM_213613	NP_998778	Q9H2B4	S26A1_HUMAN	solute carrier family 26, member 1 isoform a	76	Helical; (Potential).					integral to membrane|plasma membrane	secondary active sulfate transmembrane transporter activity			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ATGACCAGCCCAGACATGACG	0.662													5	88					0.000602214	0.00257196	1	0	A	985266	A	A	985266	3	1	237	1	0	0	0	0	1	0	0	0	14578	594	21	4	1990	4	SLC26A1	4	985266	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08		985266	190169010	27	43231											
NDUFS6	4726	broad.mit.edu	37	chr5	1801421	1801422	+	5'Flank	INS	-	CC	CC																															cctctgccccgacccgcgctINSccccgcccccagggcgaaat																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr5:1801421_1801422insCC	uc003jcy.2	+						MRPL36_uc003jcx.3_5'Flank	NM_004553	NP_004544	O75380	NDUS6_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 6,						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)	1					NADH(DB00157)	CGACCCGCGCTCCCCGCCCCCA	0.629													---	---	---								CC	1801422	CC	CC	1801421	6	5	237	0	1	1	1	0	0	0	0	0	10350	1566	54	0		0	NDUFS6	5	1801421	5'Flank	INS	-	TCGA-CV-7247-01A-11D-2012-08		1801421	179113839	28	43232											
PCDHB1	29930	broad.mit.edu	37	chr5	140432406	140432406	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acgttaatgacaatcctccaAtatttcgggaagattcctat	13	13	6	9	2	0	2	0	1	0	1	4	3	3	3	3	1	0	1	3	1	6	5			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr5:140432406A>T	uc003lik.1	+	1	1428	c.1351A>T	c.(1351-1353)ATA>TTA	p.I451L		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	451	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAATCCTCCAATATTTCGGGA	0.423													9	60					0	0	0	0	T	140432406	T	T	140432406	3	4	237	1	0	0	0	0	1	0	0	0	11588	101	4	5	1353	5	PCDHB1	5	140432406	Missense_Mutation	SNP	A	TCGA-CV-7247-01A-11D-2012-08	138630985	140432406	40482854	29	43233											
HTR4	3360	broad.mit.edu	37	chr5	147845444	147845444	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagttagacaggaactggtCtattgcagaagagcaggagg	14	7	15	5	0	1	4	0	0	1	4	1	6	1	6	0	4	3	3	0	4	4	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr5:147845444C>G	uc003lpi.1	-	7	1285	c.1121G>C	c.(1120-1122)AGA>ACA	p.R374T	HTR4_uc010jgu.1_RNA|HTR4_uc003lpj.1_Intron	NM_199453	NP_955525	Q13639	5HT4R_HUMAN	serotonin 5-HT4 receptor isoform g	Error:Variant_position_missing_in_Q13639_after_alignment					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	AGGAACTGGTCTATTGCAGAA	0.443													5	144					0	0	0	0	G	147845444	G	G	147845444	3	3	237	1	0	0	0	0	1	0	0	0	7488	913	32	2	111	2	HTR4	5	147845444	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	7413038	147845444	33069816	30	43234											
BCKDHB	594	broad.mit.edu	37	chr6	80878708	80878708	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggctctctatcattctcaGagtcctgaagcattttttgc	7	15	9	10	0	3	2	2	1	2	1	6	2	4	2	1	2	2	2	1	2	2	5			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr6:80878708G>A	uc003pjd.2	+	5	661	c.594G>A	c.(592-594)CAG>CAA	p.Q198Q	BCKDHB_uc003pje.2_Silent_p.Q198Q	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta	198					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		ATCATTCTCAGAGTCCTGAAG	0.423													7	81					0	0	0	0	A	80878708	A	A	80878708	2	1	237	1	0	0	0	0	0	0	0	1	1362	933	33	2		2	BCKDHB	6	80878708	Silent	SNP	G	TCGA-CV-7247-01A-11D-2012-08		80878708	90236359	31	43235											
UNC93A	54346	broad.mit.edu	37	chr6	167721317	167721317	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccctactgctgtggagacctCgtgctgaccatctggcagtg	6	10	12	13	1	1	2	0	1	1	1	2	3	1	2	3	2	3	3	3	2	1	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr6:167721317C>T	uc003qvq.2	+	7	1202	c.1027C>T	c.(1027-1029)CGT>TGT	p.R343C	UNC93A_uc003qvr.2_Missense_Mutation_p.R301C	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	343						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GTGGAGACCTCGTGCTGACCA	0.617													7	63					0	0	0	0	T	167721317	T	T	167721317	3	4	237	1	0	0	0	0	1	0	0	0	17064	884	31	1	1053	1	UNC93A	6	167721317	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	86842609	167721317	3393750	32	43236											
THSD7A	221981	broad.mit.edu	37	chr7	11468652	11468652	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccatttagaacgaaccttCacaccactcccacaggactt	13	8	5	15	1	1	1	1	0	0	1	2	3	2	2	4	1	3	0	4	1	3	4			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:11468652C>G	uc003ssf.3	-	14	3417	c.3165G>C	c.(3163-3165)GTG>GTC	p.V1055V		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1055	TSP type-1 11.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		AACGAACCTTCACACCACTCC	0.517										HNSCC(18;0.044)			17	317					0	0	0	0	G	11468652	G	G	11468652	2	3	237	1	0	0	0	0	0	0	0	1	15945	813	29	2		2	THSD7A	7	11468652	Silent	SNP	C	TCGA-CV-7247-01A-11D-2012-08		11468652	147670011	33	43237											
AMPH	273	broad.mit.edu	37	chr7	38671031	38671033	+	5'Flank	DEL	GGA	-	-																															gaggagcgggaggaggagcgGgaggaggaggagagggccga																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	43395582-90ea-4e50-83a5-6395b7aef658	g.chr7:38671031_38671033delGGA	uc003tgu.2	-						AMPH_uc003tgv.2_5'Flank	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1						endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						aggaggagcgggaggaggaggag	0.296													---	---	---								-	38671033	-	-	38671031	6	5	237	0	1	1	0	1	0	0	0	0	588	1247	43	0		0	AMPH	7	38671031	5'Flank	DEL	GGA	TCGA-CV-7247-01A-11D-2012-08	27202379	38671031	120467632	34	43238											
LMTK2	22853	broad.mit.edu	37	chr7	97820131	97820132	+	Frame_Shift_Del	DEL	AG	-	-																															atgtcctcaaccaagtcattAgagagagagacacaaaactc																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:97820131_97820132delAG	uc003upd.1	+	10	1383_1384	c.1090_1091delAG	c.(1090-1092)AGAfs	p.R364fs		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	364	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CCAAGTCATTAGAGAGAGAGAC	0.495													---	---	---								-	97820132	-	-	97820131	7	5	237	1	0	1	0	1	0	0	0	0	8901	412	15	0	1128	0	LMTK2	7	97820131	Frame_Shift_Del	DEL	AG	TCGA-CV-7247-01A-11D-2012-08	59149100	97820131	61318532	35	43239											
SRRT	51593	broad.mit.edu	37	chr7	100483362	100483362	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttatgcgggtggcgctctCagagccccagccagagagga	8	7	14	12	2	1	2	1	0	1	2	2	4	1	3	3	3	3	1	3	3	1	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:100483362C>T	uc003uwy.2	+	12	1626	c.1358C>T	c.(1357-1359)TCA>TTA	p.S453L	SRRT_uc010lhl.1_Missense_Mutation_p.S452L|SRRT_uc003uxa.2_Missense_Mutation_p.S452L|SRRT_uc003uwz.2_Missense_Mutation_p.S453L	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	453					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GTGGCGCTCTCAGAGCCCCAG	0.537													18	99					0	0	0	0	T	100483362	T	T	100483362	3	4	237	1	0	0	0	0	1	0	0	0	15238	838	29	2	1396	2	SRRT	7	100483362	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	2663231	100483362	58655301	36	43240											
PRKRIP1	79706	broad.mit.edu	37	chr7	102036770	102036785	+	5'Flank	DEL	GGAGACTGCGTATGCG	-	-																															ccgcctccgttcccctctgcGgagactgcgtatgcgtcgcc																								rs150672122		TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	43395582-90ea-4e50-83a5-6395b7aef658	g.chr7:102036770_102036785delGGAGACTGCGTATGCG	uc003uzh.2	+						PRKRIP1_uc003uzf.2_Intron|PRKRIP1_uc003uzg.2_Intron|PRKRIP1_uc011kkq.1_Intron|PRKRIP1_uc011kkr.1_5'Flank	NM_024653	NP_078929	Q9H875	PKRI1_HUMAN	PRKR interacting protein 1 (IL11 inducible)							nucleolus				ovary(1)	1						TCCCCTCTGCGGAGACTGCGTATGCGTCGCCGGCGC	0.644													---	---	---								-	102036785	-	-	102036770	6	5	237	0	1	1	0	1	0	0	0	0	12587	1131	39	0		0	PRKRIP1	7	102036770	5'Flank	DEL	GGAGACTGCGTATGCG	TCGA-CV-7247-01A-11D-2012-08	1553408	102036770	57101893	37	43241											
CPA4	51200	broad.mit.edu	37	chr7	129948151	129948151	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtggctttttcagaaccGattatggaggaagacgcggt	9	12	14	6	3	1	2	1	0	0	2	1	5	1	4	1	5	1	1	1	5	3	4			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:129948151G>T	uc003vpr.2	+	8	754	c.707G>T	c.(706-708)CGA>CTA	p.R236L	CPA4_uc011kpd.1_Missense_Mutation_p.R203L|CPA4_uc011kpe.1_Missense_Mutation_p.R132L	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	236					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TTTCAGAACCGATTATGGAGG	0.557													18	44					6.94344e-10	3.23501e-09	1	0	T	129948151	T	T	129948151	3	4	237	1	0	0	0	0	1	0	0	0	3807	1058	37	3	737	3	CPA4	7	129948151	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	27911381	129948151	29190512	38	43242											
SSPO	23145	broad.mit.edu	37	chr7	149488643	149488643	+	Frame_Shift_Del	DEL	C	-	-																															cagggttgtggggcctggggCccctggagcccatgggggcc																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr7:149488643delC	uc010lpk.2	+	35	5094	c.5094delC	c.(5092-5094)GGCfs	p.G1698fs		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1698	TSP type-1 1.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGGCCTGGGGCCCCTGGAGCC	0.721													---	---	---								-	149488643	-	-	149488643	7	5	237	1	0	1	0	1	0	0	0	0	15255	726	26	0	5224	0	SSPO	7	149488643	Frame_Shift_Del	DEL	C	TCGA-CV-7247-01A-11D-2012-08	19540492	149488643	9650020	39	43243											
FAM110B	90362	broad.mit.edu	37	chr8	59059406	59059406	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttcggacatccgcaaggTgaccagcgtgaagcccctca	9	7	10	15	3	2	2	1	2	1	0	4	3	3	3	4	2	2	1	4	2	2	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr8:59059406T>C	uc003xtj.1	+	5	1497	c.617T>C	c.(616-618)GTG>GCG	p.V206A		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	206						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				ATCCGCAAGGTGACCAGCGTG	0.657													11	72					0	0	0	0	C	59059406	C	C	59059406	3	2	237	1	0	0	0	0	1	0	0	0	5425	1696	59	5	619	5	FAM110B	8	59059406	Missense_Mutation	SNP	T	TCGA-CV-7247-01A-11D-2012-08		59059406	87304616	40	43244											
SULF1	23213	broad.mit.edu	37	chr8	70536227	70536227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agacacgttccttgtccgtcGaatttgaaggtgaaatatat	12	13	9	7	3	0	3	0	2	0	1	3	4	2	3	2	1	0	1	2	1	5	5			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr8:70536227G>A	uc010lza.1	+	15	2362	c.1645G>A	c.(1645-1647)GAA>AAA	p.E549K	SULF1_uc003xyd.2_Missense_Mutation_p.E549K|SULF1_uc003xye.2_Missense_Mutation_p.E549K|SULF1_uc003xyf.2_Missense_Mutation_p.E549K|SULF1_uc003xyg.2_Missense_Mutation_p.E549K|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	549					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CTTGTCCGTCGAATTTGAAGG	0.408													11	63					0	0	0	0	A	70536227	A	A	70536227	3	1	237	1	0	0	0	0	1	0	0	0	15436	1059	37	1	1687	1	SULF1	8	70536227	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	11476821	70536227	75827795	41	43245											
PTDSS1	9791	broad.mit.edu	37	chr8	97318687	97318687	+	Frame_Shift_Del	DEL	A	-	-																															ttcagctgactgagttgaatAccttcttcttgaagcatatc																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr8:97318687delA	uc003yht.1	+	8	1012	c.910delA	c.(910-912)ACCfs	p.T304fs	PTDSS1_uc003yhu.1_Frame_Shift_Del_p.T158fs	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	304	Helical; (Potential).				phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TGAGTTGAATACCTTCTTCTT	0.393													---	---	---								-	97318687	-	-	97318687	7	5	237	1	0	1	0	1	0	0	0	0	12798	391	14	0	940	0	PTDSS1	8	97318687	Frame_Shift_Del	DEL	A	TCGA-CV-7247-01A-11D-2012-08	26782460	97318687	49045335	42	43246											
TEK	7010	broad.mit.edu	37	chr9	27220088	27220088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgacttgtgcagaactctacGagaagctgccccagggctac	10	8	11	12	1	1	3	0	1	1	2	1	4	1	3	2	1	6	3	2	1	4	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr9:27220088G>A	uc003zqi.3	+	21	3587	c.3145G>A	c.(3145-3147)GAG>AAG	p.E1049K	TEK_uc011lno.1_Missense_Mutation_p.E1006K|TEK_uc011lnp.1_Missense_Mutation_p.E901K	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	1049	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		AGAACTCTACGAGAAGCTGCC	0.532													6	96					0	0	0	0	A	27220088	A	A	27220088	3	1	237	1	0	0	0	0	1	0	0	0	15817	1059	37	1	3227	1	TEK	9	27220088	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08		27220088	113993343	43	43247											
ASPN	54829	broad.mit.edu	37	chr9	95236914	95236914	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatattcttacctaaatctGagcaatgtacaactcgtgaa	14	14	5	8	1	2	2	0	2	2	0	3	2	2	2	1	0	4	2	1	0	9	6			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr9:95236914G>C	uc004ase.1	-	2	510	c.266C>G	c.(265-267)TCA>TGA	p.S89*	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ASPN_uc010mqy.1_Nonsense_Mutation_p.S89*	NM_017680	NP_060150	Q9BXN1	ASPN_HUMAN	asporin precursor	89	LRRNT.|Cys-rich.				bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding				0						ACCTAAATCTGAGCAATGTAC	0.323													4	26					0	0	0	0	C	95236914	C	C	95236914	4	2	237	1	0	0	0	0	0	1	0	0	1059	1294	45	2	904	2	ASPN	9	95236914	Nonsense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	68016826	95236914	45976517	44	43248											
TNKS2	80351	broad.mit.edu	37	chr10	93602105	93602105	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctcctgataatgtaaattgCcgcgatacccaaggcagaca	13	9	8	11	2	1	2	0	1	1	1	2	3	1	2	3	1	2	2	3	1	5	4			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr10:93602105C>T	uc001khp.2	+	16	2313	c.2016C>T	c.(2014-2016)TGC>TGT	p.C672C		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	672					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				ATGTAAATTGCCGCGATACCC	0.418													4	44					0	0	0	0	T	93602105	T	T	93602105	2	4	237	1	0	0	0	0	0	0	0	1	16387	747	26	4		4	TNKS2	10	93602105	Silent	SNP	C	TCGA-CV-7247-01A-11D-2012-08		93602105	41932642	45	43249											
PDE6C	5146	broad.mit.edu	37	chr10	95386572	95386572	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttccccaaggacgcctcctGcagaccactggacactcatt	9	8	7	17	1	1	1	1	0	0	1	3	3	3	3	5	2	1	1	5	2	1	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr10:95386572G>T	uc001kiu.3	+	7	1153	c.1015G>T	c.(1015-1017)GCA>TCA	p.A339S		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	339	GAF 2.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				GACGCCTCCTGCAGACCACTG	0.378													6	39					8.12818e-05	0.000354527	1	0	T	95386572	T	T	95386572	3	4	237	1	0	0	0	0	1	0	0	0	11701	1319	46	4	1041	4	PDE6C	10	95386572	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	1784467	95386572	40148175	46	43250											
C10orf95	79946	broad.mit.edu	37	chr10	104210810	104210810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagctgcggcggcggcggcCagacgccctgtttgggcggc	3	5	19	14	6	0	1	0	0	0	1	0	1	0	1	2	6	2	3	2	6	0	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr10:104210810C>T	uc001kvo.1	-	2	253	c.178G>A	c.(178-180)GGC>AGC	p.G60S	uc001kvp.1_Intron|uc001kvq.1_Intron|uc001kvr.1_5'Flank	NM_024886	NP_079162	Q9H7T3	CJ095_HUMAN	hypothetical protein LOC79946	60	Arg/Pro-rich.									liver(1)	1		Colorectal(252;0.207)		Epithelial(162;8.34e-09)|all cancers(201;1.95e-07)|BRCA - Breast invasive adenocarcinoma(275;0.213)		CGGCGGCGGCCAGACGCCCTG	0.716													7	16					0	0	0	0	T	104210810	T	T	104210810	3	4	237	1	0	0	0	0	1	0	0	0	1632	594	21	4	599	4	C10orf95	10	104210810	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	8824238	104210810	31323937	47	43251											
STK33	65975	broad.mit.edu	37	chr11	8414255	8414255	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aattgcttttcataagcagtAgactgcaaataaaaggtctt	15	13	7	6	0	2	1	1	0	1	1	2	1	2	1	0	1	3	4	0	1	6	7			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:8414255A>C	uc001mgi.1	-	12	2266	c.1347T>G	c.(1345-1347)TCT>TCG	p.S449S	STK33_uc001mgj.1_Silent_p.S449S|STK33_uc001mgk.1_Silent_p.S449S|STK33_uc010rbn.1_Silent_p.S408S|STK33_uc001mgl.3_Silent_p.S262S	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	449						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		CATAAGCAGTAGACTGCAAAT	0.378													28	49					0	0	0	0	C	8414255	C	C	8414255	2	2	237	1	0	0	0	0	0	0	0	1	15366	407	15	5		5	STK33	11	8414255	Silent	SNP	A	TCGA-CV-7247-01A-11D-2012-08		8414255	126592261	48	43252											
EIF4G2	1982	broad.mit.edu	37	chr11	10821256	10821260	+	Frame_Shift_Del	DEL	CCTTT	-	-																															tgggaataagaaactcagtcCctttccttccaaaatctcca																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:10821256_10821260delCCTTT	uc001mjc.2	-	19	2580_2584	c.2163_2167delAAAGG	c.(2161-2169)GGAAAGGGAfs	p.G721fs	EIF4G2_uc001mjb.2_Frame_Shift_Del_p.G515fs|EIF4G2_uc009ygf.2_Frame_Shift_Del_p.G515fs|EIF4G2_uc001mjd.2_Frame_Shift_Del_p.G683fs	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	721_723	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AAACTCAGTCCCTTTCCTTCCAAAA	0.385													---	---	---								-	10821260	-	-	10821256	7	5	237	1	0	1	0	1	0	0	0	0	5061	632	22	0	572	0	EIF4G2	11	10821256	Frame_Shift_Del	DEL	CCTTT	TCGA-CV-7247-01A-11D-2012-08	2407001	10821256	124185260	49	43253											
TRIM48	79097	broad.mit.edu	37	chr11	55032644	55032644	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctggctattcctgagctctGaggagcaaatgtgtggcatt	8	13	12	8	0	2	2	0	2	2	0	3	3	3	3	1	3	2	4	1	3	2	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:55032644G>A	uc010rid.1	+	2	399	c.313G>A	c.(313-315)GAG>AAG	p.E105K		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	89	B box-type.					intracellular	zinc ion binding				0						CCTGAGCTCTGAGGAGCAAAT	0.483													8	61					0	0	0	0	A	55032644	A	A	55032644	3	1	237	1	0	0	0	0	1	0	0	0	16590	1291	45	2	319	2	TRIM48	11	55032644	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	44211388	55032644	79973872	50	43254											
OR4C6	219432	broad.mit.edu	37	chr11	55433284	55433284	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctttcttatcttaattgcGtcctacacggtcatcctatg	8	17	5	11	2	4	0	1	0	3	0	6	0	6	0	2	1	2	0	2	1	4	6			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:55433284G>A	uc001nht.3	+	3	907	c.642G>A	c.(640-642)GCG>GCA	p.A214A	OR4C6_uc010rik.1_Silent_p.A214A	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	214	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TCTTAATTGCGTCCTACACGG	0.517													30	86					0	0	0	0	A	55433284	A	A	55433284	2	1	237	1	0	0	0	0	0	0	0	1	11106	1132	40	1		1	OR4C6	11	55433284	Silent	SNP	G	TCGA-CV-7247-01A-11D-2012-08	400640	55433284	79573232	51	43255											
CYBASC3	220002	broad.mit.edu	37	chr11	61124072	61124072	+	Missense_Mutation	SNP	A	T	T																															ttgaacatgtagatgctgccAttccaggcaaagccaccacg																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:61124072A>T	uc001nrf.3	-	1	290	c.114T>A	c.(112-114)AAT>AAA	p.N38K	CYBASC3_uc010rlh.1_Missense_Mutation_p.N55K|CYBASC3_uc001nrg.2_Missense_Mutation_p.N38K|CYBASC3_uc009ynn.2_RNA|CYBASC3_uc001nrh.2_Missense_Mutation_p.N38K|CYBASC3_uc001nri.2_Intron|CYBASC3_uc009yno.2_Missense_Mutation_p.N38K	NM_001161452	NP_001154924	Q8NBI2	CYAC3_HUMAN	cytochrome b, ascorbate dependent 3 isoform 2	38	Cytochrome b561.				electron transport chain|transport	integral to membrane|late endosome membrane|lysosomal membrane	metal ion binding|oxidoreductase activity				0						AGATGCTGCCATTCCAGGCAA	0.547													24	91					0	0	0	0	T	61124072	T	T	61124072	3	4	237	1	0	0	0	0	1	0	0	0	4149	214	8	5	634	5	CYBASC3	11	61124072	Missense_Mutation	SNP	A	TCGA-CV-7247-01A-11D-2012-08	5690788	61124072	73882444	52	43256	90	2									
CYBASC3	220002	broad.mit.edu	37	chr11	61124075	61124075	+	Missense_Mutation	SNP	C	A	A																															aacatgtagatgctgccattCcaggcaaagccaccacgcca																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr11:61124075C>A	uc001nrf.3	-	1	287	c.111G>T	c.(109-111)TGG>TGT	p.W37C	CYBASC3_uc010rlh.1_Missense_Mutation_p.W54C|CYBASC3_uc001nrg.2_Missense_Mutation_p.W37C|CYBASC3_uc009ynn.2_RNA|CYBASC3_uc001nrh.2_Missense_Mutation_p.W37C|CYBASC3_uc001nri.2_Intron|CYBASC3_uc009yno.2_Missense_Mutation_p.W37C	NM_001161452	NP_001154924	Q8NBI2	CYAC3_HUMAN	cytochrome b, ascorbate dependent 3 isoform 2	37	Cytochrome b561.				electron transport chain|transport	integral to membrane|late endosome membrane|lysosomal membrane	metal ion binding|oxidoreductase activity				0						TGCTGCCATTCCAGGCAAAGC	0.547													20	90					2.37509e-13	1.14563e-12	1	0	A	61124075	A	A	61124075	3	1	237	1	0	0	0	0	1	0	0	0	4149	856	30	2	637	2	CYBASC3	11	61124075	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	3	61124075	73882441	53	43257	90	2									
CACNA1C	775	broad.mit.edu	37	chr12	2224421	2224421	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagcccacgccccgcccaTgccaacatgaatgccaatgc	10	4	10	17	2	0	1	0	1	0	0	0	2	0	2	6	1	5	0	6	1	3	0			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:2224421T>A	uc009zdu.1	+	2	394	c.81T>A	c.(79-81)CAT>CAA	p.H27Q	CACNA1C_uc009zdv.1_Missense_Mutation_p.H27Q|CACNA1C_uc001qkb.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkc.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qke.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkf.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qjz.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkd.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkg.2_Missense_Mutation_p.H27Q|CACNA1C_uc009zdw.1_Missense_Mutation_p.H27Q|CACNA1C_uc001qkh.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkl.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkn.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qko.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkp.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkr.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qku.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkq.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qks.2_Missense_Mutation_p.H27Q|CACNA1C_uc001qkt.2_Missense_Mutation_p.H27Q	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	27	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCCCCGCCCATGCCAACATGA	0.622													6	9					0	0	0	0	A	2224421	A	A	2224421	3	1	237	1	0	0	0	0	1	0	0	0	2552	1461	51	5	87	5	CACNA1C	12	2224421	Missense_Mutation	SNP	T	TCGA-CV-7247-01A-11D-2012-08		2224421	131627474	54	43258											
ETV6	2120	broad.mit.edu	37	chr12	12022466	12022466	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctatcacgacaaatcaccGgccttctcctgaccccgagc	10	7	6	18	3	3	1	2	1	1	0	4	3	3	1	6	1	1	0	6	1	2	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:12022466G>A	uc001qzz.2	+	5	846	c.572G>A	c.(571-573)CGG>CAG	p.R191Q	ETV6_uc001raa.1_5'UTR	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	191						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				ACAAATCACCGGCCTTCTCCT	0.642			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								56	336					0	0	0	0	A	12022466	A	A	12022466	3	1	237	1	0	0	0	0	1	0	0	0	5307	1116	39	1	590	1	ETV6	12	12022466	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	9798045	12022466	121829429	55	43259											
PDE3A	5139	broad.mit.edu	37	chr12	20832977	20832977	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attttagaaaagaagactttCaaaaggagaaaaatctactg	20	10	7	4	0	2	4	1	0	1	4	2	5	2	4	0	1	1	0	0	1	9	4			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:20832977C>G	uc001reh.1	+	16	3220	c.3198C>G	c.(3196-3198)TTC>TTG	p.F1066L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	1066	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AGAAGACTTTCAAAAGGAGAA	0.358													7	57					0	0	0	0	G	20832977	G	G	20832977	3	3	237	1	0	0	0	0	1	0	0	0	11691	825	29	2	3260	2	PDE3A	12	20832977	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	8810511	20832977	113018918	56	43260											
ABCC9	10060	broad.mit.edu	37	chr12	21967641	21967641	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgatttcccactgccagtgcGaccacatatgcccacctagg	9	9	8	15	1	0	1	0	1	0	0	1	2	1	1	5	1	3	0	5	1	2	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:21967641G>A	uc001rfi.1	-	33	4059	c.4039C>T	c.(4039-4041)CGC>TGC	p.R1347C	ABCC9_uc001rfh.2_Missense_Mutation_p.R1347C|ABCC9_uc001rfj.1_Missense_Mutation_p.R1311C	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1347	Cytoplasmic (Potential).|ATP 2 (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTGCCAGTGCGACCACATATG	0.388													8	47					0	0	0	0	A	21967641	A	A	21967641	3	1	237	1	0	0	0	0	1	0	0	0	59	1058	37	1	776	1	ABCC9	12	21967641	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	1134664	21967641	111884254	57	43261											
PAN2	9924	broad.mit.edu	37	chr12	56717351	56717351	+	Frame_Shift_Del	DEL	T	-	-																															cacaattgatgacaagaataTctggcagatggcggatgttg																								rs138946880		TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:56717351delT	uc001skx.2	-	15	2589	c.2216delA	c.(2215-2217)GATfs	p.D739fs	PAN2_uc001skw.2_5'UTR|PAN2_uc001skz.2_Frame_Shift_Del_p.D738fs|PAN2_uc001sky.2_Frame_Shift_Del_p.D735fs	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	739					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						GACAAGAATATCTGGCAGATG	0.488													---	---	---								-	56717351	-	-	56717351	7	5	237	1	0	1	0	1	0	0	0	0	11468	1435	50	0	1440	0	PAN2	12	56717351	Frame_Shift_Del	DEL	T	TCGA-CV-7247-01A-11D-2012-08	34749710	56717351	77134544	58	43262											
RASAL1	8437	broad.mit.edu	37	chr12	113537802	113537802	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaactcctcgtgggcacgatCcaggtctgcgagcacctcca	8	7	11	15	3	1	0	0	0	1	0	5	3	4	0	4	2	3	2	4	2	1	0			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr12:113537802C>A	uc001tum.1	-	22	2640	c.2347G>T	c.(2347-2349)GAT>TAT	p.D783Y	RASAL1_uc010syp.1_Missense_Mutation_p.D784Y|RASAL1_uc001tul.2_Missense_Mutation_p.D755Y|RASAL1_uc001tun.1_Missense_Mutation_p.D785Y	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	783					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						TGGGCACGATCCAGGTCTGCG	0.677													13	34					5.50884e-06	2.42863e-05	1	0	A	113537802	A	A	113537802	3	1	237	1	0	0	0	0	1	0	0	0	13128	855	30	2	71	2	RASAL1	12	113537802	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	56820451	113537802	20314093	59	43263											
DIS3	22894	broad.mit.edu	37	chr13	73346872	73346872	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catctttggcagaaaactaaGaacagcctgtgaaaaaggct	16	8	9	8	0	1	3	0	1	1	2	1	3	1	3	1	2	3	2	1	2	6	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr13:73346872G>A	uc001vix.3	-	9	1719	c.1345C>T	c.(1345-1347)CTT>TTT	p.L449F	DIS3_uc001viy.3_Missense_Mutation_p.L419F|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	449					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		AGAAAACTAAGAACAGCCTGT	0.363										Multiple Myeloma(4;0.011)			4	98					0	0	0	0	A	73346872	A	A	73346872	3	1	237	1	0	0	0	0	1	0	0	0	4557	942	33	2	1583	2	DIS3	13	73346872	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08		73346872	41823006	60	43264											
PCCA	5095	broad.mit.edu	37	chr13	100861712	100861712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctggctttgatggagtaGtcaaggtgagaagctacttt	9	13	12	7	0	1	2	1	2	0	1	2	4	2	3	1	3	2	3	1	3	4	4			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr13:100861712G>A	uc001voo.2	+	7	633	c.595G>A	c.(595-597)GTC>ATC	p.V199I	PCCA_uc010aga.2_Missense_Mutation_p.V173I|PCCA_uc010tiz.1_Missense_Mutation_p.V199I	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	199	ATP-grasp.|Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	TGATGGAGTAGTCAAGGTGAG	0.338													10	63					0	0	0	0	A	100861712	A	A	100861712	3	1	237	1	0	0	0	0	1	0	0	0	11558	1029	36	4	621	4	PCCA	13	100861712	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	27514840	100861712	14308166	61	43265											
HECTD1	25831	broad.mit.edu	37	chr14	31597034	31597034	+	Frame_Shift_Del	DEL	G	-	-																															tgacctgtgtcactctcactGgaagttgatgtgaggctggt																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr14:31597034delG	uc001wrc.1	-	26	5427	c.4938delC	c.(4936-4938)TCCfs	p.S1646fs	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Frame_Shift_Del_p.S1114fs	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1646	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CACTCTCACTGGAAGTTGATG	0.353													---	---	---								-	31597034	-	-	31597034	7	5	237	1	0	1	0	1	0	0	0	0	7078	1335	47	0	2966	0	HECTD1	14	31597034	Frame_Shift_Del	DEL	G	TCGA-CV-7247-01A-11D-2012-08		31597034	75752506	62	43266											
NEIL1	79661	broad.mit.edu	37	chr15	75641409	75641409	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagcttcagcccgcggcaagGagctgcgcctgatactgagc	8	6	13	14	3	1	2	1	2	0	0	1	3	1	3	2	2	6	3	2	2	2	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr15:75641409G>A	uc002bad.2	+	2	669	c.163G>A	c.(163-165)GAG>AAG	p.E55K	NEIL1_uc002bae.2_Missense_Mutation_p.E141K	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1	55					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			ovary(1)	1						CCGCGGCAAGGAGCTGCGCCT	0.647								BER_DNA_glycosylases					4	49					0	0	0	0	A	75641409	A	A	75641409	3	1	237	1	0	0	0	0	1	0	0	0	10372	1175	41	2	165	2	NEIL1	15	75641409	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08		75641409	26889983	63	43267											
KIAA1024	23251	broad.mit.edu	37	chr15	79750590	79750590	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcgggtcaaggccttaaaaAaaagcctcttcaccaggcca	13	7	9	12	1	3	0	2	0	1	0	3	0	3	0	4	3	2	0	4	3	5	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr15:79750590A>T	uc002bew.1	+	2	2176	c.2101A>T	c.(2101-2103)AAA>TAA	p.K701*	KIAA1024_uc010unk.1_Nonsense_Mutation_p.K701*	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	701						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						GGCCTTAAAAAAAAGCCTCTT	0.552													12	108					0	0	0	0	T	79750590	T	T	79750590	4	4	237	1	0	0	0	0	0	1	0	0	8244	15	1	5	2103	5	KIAA1024	15	79750590	Nonsense_Mutation	SNP	A	TCGA-CV-7247-01A-11D-2012-08	4109181	79750590	22780802	64	43268											
PKD1	5310	broad.mit.edu	37	chr16	2159543	2159543	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaggttgtacgtggctgaGacccagctgactgcgttgga	7	10	16	8	2	0	3	0	3	0	1	0	5	0	4	1	3	3	5	1	3	1	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr16:2159543G>C	uc002cos.1	-	15	5834	c.5625C>G	c.(5623-5625)GTC>GTG	p.V1875V	PKD1_uc002cot.1_Silent_p.V1875V	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1875	PKD 14.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						ACGTGGCTGAGACCCAGCTGA	0.652													8	13					0	0	0	0	C	2159543	C	C	2159543	2	2	237	1	0	0	0	0	0	0	0	1	12018	929	33	2		2	PKD1	16	2159543	Silent	SNP	G	TCGA-CV-7247-01A-11D-2012-08		2159543	88195210	65	43269											
ALG1	56052	broad.mit.edu	37	chr16	5127458	5127458	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttcaggtacgagaagttCtttgggcgcctgtcccacct	6	13	10	12	2	2	1	1	0	1	1	3	2	3	1	3	2	1	2	3	2	2	5			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr16:5127458C>A	uc002cym.2	+	5	593	c.552C>A	c.(550-552)TTC>TTA	p.F184L	ALG1_uc002cyj.2_Missense_Mutation_p.F73L|ALG1_uc002cyn.2_Missense_Mutation_p.F184L|ALG1_uc010bue.2_Missense_Mutation_p.F73L|ALG1_uc010uxy.1_Missense_Mutation_p.F73L	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	184	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)				ACGAGAAGTTCTTTGGGCGCC	0.552													19	100					1.01871e-10	4.80083e-10	1	0	A	5127458	A	A	5127458	3	1	237	1	0	0	0	0	1	0	0	0	510	912	32	2	570	2	ALG1	16	5127458	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	2967915	5127458	85227295	66	43270											
LOC339047	339047	broad.mit.edu	37	chr16	16425564	16425564	+	5'Flank	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcgttctcctcatctgTctcttcctgggcgccaacgc	3	13	9	16	3	4	0	1	0	3	0	7	0	5	0	3	1	3	2	3	1	1	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr16:16425564T>C	uc002dev.3	+						LOC339047_uc010vad.1_RNA|LOC339047_uc010vae.1_RNA|LOC339047_uc002dew.3_5'Flank	NM_178541	NP_848636			hypothetical protein LOC339047												0						TCCTCATCTGTCTCTTCCTGG	0.627													2	5					0	0	0	0	C	16425564	C	C	16425564	1	2	237	0	1	0	0	0	0	0	0	0	8922	1682	58	5		5	LOC339047	16	16425564	5'Flank	SNP	T	TCGA-CV-7247-01A-11D-2012-08	11298106	16425564	73929189	67	43271											
RNF40	9810	broad.mit.edu	37	chr16	30779808	30779808	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaaggtggaagaaaccaagCggaaggaatcagaactcctc	16	4	11	10	1	1	2	1	0	0	2	3	5	2	5	3	4	3	0	3	4	7	0			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr16:30779808C>A	uc002dzq.2	+	13	2059	c.1936C>A	c.(1936-1938)CGG>AGG	p.R646R	RNF40_uc010caa.2_Silent_p.R646R|RNF40_uc010cab.2_Silent_p.R546R|RNF40_uc010vfa.1_5'UTR|RNF40_uc002dzr.2_Silent_p.R646R|RNF40_uc010vfb.1_Silent_p.R338R|RNF40_uc010vfc.1_5'UTR	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	646	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			AGAAACCAAGCGGAAGGAATC	0.597													4	75					0.00024832	0.0010717	1	0	A	30779808	A	A	30779808	2	1	237	1	0	0	0	0	0	0	0	1	13558	759	27	3		3	RNF40	16	30779808	Silent	SNP	C	TCGA-CV-7247-01A-11D-2012-08	14354244	30779808	59574945	68	43272											
ANKRD11	29123	broad.mit.edu	37	chr16	89348419	89348419	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttgtctttgagcacgcgggGcgggctgtccttgtccctgg	2	12	15	12	3	1	1	0	1	1	0	3	1	3	1	2	4	1	2	2	4	0	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr16:89348419G>A	uc002fmx.1	-	9	4992	c.4531C>T	c.(4531-4533)CCC>TCC	p.P1511S	ANKRD11_uc002fmy.1_Missense_Mutation_p.P1511S|ANKRD11_uc002fnc.1_Missense_Mutation_p.P1511S|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.P1468S	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1511	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		AGCACGCGGGGCGGGCTGTCC	0.632													4	66					0	0	0	0	A	89348419	A	A	89348419	3	1	237	1	0	0	0	0	1	0	0	0	639	1203	42	4	3480	4	ANKRD11	16	89348419	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	58568611	89348419	1006334	69	43273											
TP53	7157	broad.mit.edu	37	chr17	7578534	7578534	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggccagttggcaaaacatCttgttgagggcaggggagta	10	10	15	6	0	1	1	0	1	1	0	1	2	1	2	1	5	1	5	1	5	3	5			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:7578534C>G	uc002gim.2	-	5	590	c.396G>C	c.(394-396)AAG>AAC	p.K132N	TP53_uc002gig.1_Missense_Mutation_p.K132N|TP53_uc002gih.2_Missense_Mutation_p.K132N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.K132N|TP53_uc010cni.1_Missense_Mutation_p.K132N|TP53_uc002gij.2_Missense_Mutation_p.K132N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.K39N|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.K93N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	132	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> T (in sporadic cancers; somatic mutation).|KM -> NL (in a sporadic cancer; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> R (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> Q (in sporadic cancers; somatic mutation).|K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K132N(40)|p.K132R(32)|p.K132E(19)|p.K132Q(13)|p.K132M(9)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.K132T(4)|p.K132*(2)|p.N131fs*27(2)|p.K132fs*38(2)|p.Y126fs*11(1)|p.S127_Q136del10(1)|p.M133fs*16(1)|p.V73fs*9(1)|p.A129_K132delALNK(1)|p.L130_M133delLNKM(1)|p.M133fs*37(1)|p.K132_A138delKMFCQLA(1)|p.S127fs*36(1)|p.K132K(1)|p.K132W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAAAACATCTTGTTGAGGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	15					0	0	0	0	G	7578534	G	G	7578534	3	3	237	1	0	0	0	0	1	0	0	0	16448	912	32	2	902	2	TP53	17	7578534	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08		7578534	73616676	70	43274											
MYH2	4620	broad.mit.edu	37	chr17	10447033	10447033	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtccaagagacttacaaagcGagaggagttgtcattcctca	13	9	10	9	1	2	2	2	0	0	2	4	5	4	3	2	1	2	1	2	1	3	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:10447033G>A	uc010coi.2	-	8	864	c.736C>T	c.(736-738)CGC>TGC	p.R246C	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R246C|MYH2_uc010coj.2_Missense_Mutation_p.R246C	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	246	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTTACAAAGCGAGAGGAGTTG	0.448													6	54					0	0	0	0	A	10447033	A	A	10447033	3	1	237	1	0	0	0	0	1	0	0	0	10088	1058	37	1	5221	1	MYH2	17	10447033	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	2868499	10447033	70748177	71	43275											
TOP2A	7153	broad.mit.edu	37	chr17	38552685	38552685	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctttcccaggaagtccgacTtgttcatcttgtttttcctt	5	18	6	12	1	2	0	1	0	1	0	5	2	5	1	4	1	0	2	4	1	1	7			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:38552685T>G	uc002huq.2	-	28	3696	c.3570A>C	c.(3568-3570)CAA>CAC	p.Q1190H		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	1190					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	GAAGTCCGACTTGTTCATCTT	0.413													12	108					0	0	0	0	G	38552685	G	G	38552685	3	3	237	1	0	0	0	0	1	0	0	0	16432	1606	56	5	1057	5	TOP2A	17	38552685	Missense_Mutation	SNP	T	TCGA-CV-7247-01A-11D-2012-08	28105652	38552685	42642525	72	43276											
STXBP4	252983	broad.mit.edu	37	chr17	53158448	53158448	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcttctcagacttccctcAcaccactgggaaggaatgga	11	9	9	12	0	2	1	2	0	1	1	4	4	3	4	2	3	1	1	2	3	3	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:53158448A>C	uc002iuf.1	+	16	1600	c.1393A>C	c.(1393-1395)ACA>CCA	p.T465P	STXBP4_uc010dcd.1_Missense_Mutation_p.T443P	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	465						cytoplasm	calcium ion binding			ovary(1)	1						GACTTCCCTCACACCACTGGG	0.393													4	47					0	0	0	0	C	53158448	C	C	53158448	3	2	237	1	0	0	0	0	1	0	0	0	15421	159	6	5	1447	5	STXBP4	17	53158448	Missense_Mutation	SNP	A	TCGA-CV-7247-01A-11D-2012-08	14605763	53158448	28036762	73	43277											
STRADA	92335	broad.mit.edu	37	chr17	61781730	61781730	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggttgcgctgaaggcactgCtccacaaagtggtggaagtg	9	8	16	8	1	0	1	0	1	0	0	1	2	1	2	1	4	2	4	1	4	3	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:61781730C>A	uc002jbm.2	-	11	1230	c.1071G>T	c.(1069-1071)GAG>GAT	p.E357D	STRADA_uc002jbn.2_Missense_Mutation_p.E299D|STRADA_uc002jbo.2_Missense_Mutation_p.E320D|STRADA_uc002jbp.2_Missense_Mutation_p.E320D|STRADA_uc002jbq.2_Missense_Mutation_p.E299D|STRADA_uc010wpq.1_Intron|STRADA_uc010wpr.1_Intron|STRADA_uc010ddw.2_Missense_Mutation_p.E328D|STRADA_uc002jbr.2_3'UTR	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	357	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						GAAGGCACTGCTCCACAAAGT	0.662													4	25					0.00116845	0.00483902	1	0	A	61781730	A	A	61781730	3	1	237	1	0	0	0	0	1	0	0	0	15390	796	28	4	294	4	STRADA	17	61781730	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	8623282	61781730	19413480	74	43278											
AXIN2	8313	broad.mit.edu	37	chr17	63526139	63526139	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaatccggccttcatacatCgggagcaccgtctcatcctc	9	9	8	15	3	2	1	2	0	1	1	7	2	4	2	4	2	2	1	4	2	2	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:63526139C>T	uc002jfi.2	-	11	2776	c.2487G>A	c.(2485-2487)CCG>CCA	p.P829P	AXIN2_uc002jfh.2_Silent_p.P764P	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	829	DIX.				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						CTTCATACATCGGGAGCACCG	0.507									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				15	88					0	0	0	0	T	63526139	T	T	63526139	2	4	237	1	0	0	0	0	0	0	0	1	1239	871	31	1		1	AXIN2	17	63526139	Silent	SNP	C	TCGA-CV-7247-01A-11D-2012-08	1744409	63526139	17669071	75	43279											
GPS1	2873	broad.mit.edu	37	chr17	80013938	80013938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgccttggctacctttgaccGgcaggagctgcagcgcaatg	7	8	13	13	3	0	1	0	1	0	0	0	2	0	2	3	3	4	5	3	3	2	3			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr17:80013938G>A	uc002kdl.1	+	8	953	c.908G>A	c.(907-909)CGG>CAG	p.R303Q	GPS1_uc002kdk.1_Missense_Mutation_p.R339Q|GPS1_uc010dij.1_Missense_Mutation_p.R338Q|GPS1_uc002kdm.1_Missense_Mutation_p.R283Q|GPS1_uc002kdn.1_Missense_Mutation_p.R299Q|GPS1_uc002kdo.1_Missense_Mutation_p.R302Q|GPS1_uc010wvh.1_Missense_Mutation_p.R295Q	NM_004127	NP_004118	Q13098	CSN1_HUMAN	G protein pathway suppressor 1 isoform 2	303					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			ACCTTTGACCGGCAGGAGCTG	0.657													4	29					0	0	0	0	A	80013938	A	A	80013938	3	1	237	1	0	0	0	0	1	0	0	0	6771	1116	39	1	1095	1	GPS1	17	80013938	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08	16487799	80013938	1181272	76	43280											
LAMA1	284217	broad.mit.edu	37	chr18	7043287	7043287	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgattcccatggtgttctgcAagcaatttatgcaaacccct	10	13	7	11	0	1	1	0	1	1	0	2	1	2	1	3	1	4	4	3	1	4	4			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr18:7043287A>C	uc002knm.2	-	8	1188	c.1094T>G	c.(1093-1095)TTG>TGG	p.L365W	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	365	Laminin EGF-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGTTCTGCAAGCAATTTAT	0.388													58	145					0	0	0	0	C	7043287	C	C	7043287	3	2	237	1	0	0	0	0	1	0	0	0	8645	131	5	5	8357	5	LAMA1	18	7043287	Missense_Mutation	SNP	A	TCGA-CV-7247-01A-11D-2012-08		7043287	71033961	77	43281											
DCC	1630	broad.mit.edu	37	chr18	50977000	50977000	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtggtcatcgtggctgtgatTtgcacccgacgctcttcagc	5	12	12	12	3	3	1	2	1	1	0	4	2	3	1	1	2	2	3	1	2	0	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr18:50977000T>G	uc002lfe.1	+	23	3947	c.3360T>G	c.(3358-3360)ATT>ATG	p.I1120M	DCC_uc010dpf.1_Missense_Mutation_p.I755M	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1120	Helical; (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGGCTGTGATTTGCACCCGAC	0.488													6	36					0	0	0	0	G	50977000	G	G	50977000	3	3	237	1	0	0	0	0	1	0	0	0	4299	1829	64	5	3450	5	DCC	18	50977000	Missense_Mutation	SNP	T	TCGA-CV-7247-01A-11D-2012-08	43933713	50977000	27100248	78	43282											
AP3D1	8943	broad.mit.edu	37	chr19	2121250	2121250	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcacggtaggtggtaccctCtgccttgtctacgtgggtca	5	12	13	11	2	4	0	2	0	2	0	4	0	4	0	2	4	3	2	2	4	3	4			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:2121250C>T	uc002luz.2	-	13	1385	c.1162G>A	c.(1162-1164)GAG>AAG	p.E388K	AP3D1_uc002luy.2_Missense_Mutation_p.E297K|AP3D1_uc002lva.2_Missense_Mutation_p.E388K	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	388	HEAT 8.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGTACCCTCTGCCTTGTCT	0.542													6	69					0	0	0	0	T	2121250	T	T	2121250	3	4	237	1	0	0	0	0	1	0	0	0	746	922	32	2	2529	2	AP3D1	19	2121250	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08		2121250	57007733	79	43283											
ZNF823	55552	broad.mit.edu	37	chr19	11832973	11832973	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgagttgtctcatgatttTgaaaggaagagagatcacta	13	13	11	4	0	2	5	2	3	1	2	3	7	2	6	0	1	0	1	0	1	3	4			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:11832973T>G	uc002msm.2	-	4	1502	c.1376A>C	c.(1375-1377)CAA>CCA	p.Q459P	ZNF823_uc010xmd.1_Missense_Mutation_p.Q277P|ZNF823_uc010dyi.1_Missense_Mutation_p.Q415P	NM_001080493	NP_001073962	P16415	ZN823_HUMAN	ZFP-36 for a zinc finger protein	459	C2H2-type 11; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTCATGATTTTGAAAGGAAGA	0.423										HNSCC(68;0.2)			6	104					0	0	0	0	G	11832973	G	G	11832973	3	3	237	1	0	0	0	0	1	0	0	0	18246	1812	63	5	460	5	ZNF823	19	11832973	Missense_Mutation	SNP	T	TCGA-CV-7247-01A-11D-2012-08	9711723	11832973	47296010	80	43284											
ZNF440	126070	broad.mit.edu	37	chr19	11943494	11943494	+	Frame_Shift_Del	DEL	T	-	-																															ccttcagtagttccagttccTtttgatatcatgaaaggact																										TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:11943494delT	uc002msp.1	+	4	1659	c.1503delT	c.(1501-1503)CCTfs	p.P501fs		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCCAGTTCCTTTTGATATCA	0.413													---	---	---								-	11943494	-	-	11943494	7	5	237	1	0	1	0	1	0	0	0	0	17980	1596	56	0	1517	0	ZNF440	19	11943494	Frame_Shift_Del	DEL	T	TCGA-CV-7247-01A-11D-2012-08	110521	11943494	47185489	81	43285											
NCAN	1463	broad.mit.edu	37	chr19	19334919	19334919	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgtctcagctcagccatcAttgcagcccctcggcatcta	7	9	8	17	2	4	0	3	0	2	0	6	0	4	0	4	1	4	3	4	1	1	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:19334919A>G	uc002nlz.2	+	4	664	c.565A>G	c.(565-567)ATT>GTT	p.I189V	NCAN_uc010ecc.1_5'Flank	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	189	Link 1.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CTCAGCCATCATTGCAGCCCC	0.602													21	45					0	0	0	0	G	19334919	G	G	19334919	3	3	237	1	0	0	0	0	1	0	0	0	10258	217	8	5	575	5	NCAN	19	19334919	Missense_Mutation	SNP	A	TCGA-CV-7247-01A-11D-2012-08	7391425	19334919	39794064	82	43286											
CILP2	148113	broad.mit.edu	37	chr19	19655256	19655256	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggacagcgacggcgagctGgctccactgcgcacctacgg	7	5	15	14	5	0	0	0	0	0	0	1	3	1	1	2	4	4	3	2	4	1	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:19655256G>A	uc002nmv.3	+	8	1987	c.1902G>A	c.(1900-1902)CTG>CTA	p.L634L	CILP2_uc002nmw.3_Silent_p.L640L	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	634						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						ACGGCGAGCTGGCTCCACTGC	0.736													7	123					0	0	0	0	A	19655256	A	A	19655256	2	1	237	1	0	0	0	0	0	0	0	1	3445	1335	47	4		4	CILP2	19	19655256	Silent	SNP	G	TCGA-CV-7247-01A-11D-2012-08	320337	19655256	39473727	83	43287											
PSG8	440533	broad.mit.edu	37	chr19	43259212	43259212	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatttcacattgatagggtcCtgtttcatttctcgtgacac	8	17	7	9	1	3	2	2	2	1	0	5	2	4	2	1	1	0	1	1	1	2	6			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:43259212C>T	uc002ouo.2	-	4	1014	c.916G>A	c.(916-918)GGA>AGA	p.G306R	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_Intron|PSG8_uc002oui.2_Missense_Mutation_p.G145R|PSG8_uc002ouh.2_Missense_Mutation_p.G306R|PSG8_uc010ein.2_Missense_Mutation_p.G184R|PSG8_uc002ouj.3_Missense_Mutation_p.G88R|PSG8_uc002ouk.3_Missense_Mutation_p.G145R|PSG8_uc002oul.3_Missense_Mutation_p.G306R|PSG8_uc002oum.3_Missense_Mutation_p.G213R|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.G213R	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	306	Ig-like C2-type 2.					extracellular region					0		Prostate(69;0.00899)				TGATAGGGTCCTGTTTCATTT	0.498													46	206					0	0	0	0	T	43259212	T	T	43259212	3	4	237	1	0	0	0	0	1	0	0	0	12723	690	24	4	393	4	PSG8	19	43259212	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08	23603956	43259212	15869771	84	43288											
SYT3	84258	broad.mit.edu	37	chr19	51135984	51135984	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgccagggcacccagcacAacttccaggacacgaagaga	13	2	10	16	2	0	1	0	0	0	1	1	4	1	2	4	2	2	2	4	2	2	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr19:51135984A>T	uc002pst.2	-	2	867	c.233T>A	c.(232-234)TTG>TAG	p.L78*	SYT3_uc002psv.2_Nonsense_Mutation_p.L78*|SYT3_uc010ycd.1_Nonsense_Mutation_p.L78*	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	78	Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CACCCAGCACAACTTCCAGGA	0.632													6	99					0	0	0	0	T	51135984	T	T	51135984	4	4	237	1	0	0	0	0	0	1	0	0	15541	131	5	5	1567	5	SYT3	19	51135984	Nonsense_Mutation	SNP	A	TCGA-CV-7247-01A-11D-2012-08	7876772	51135984	7992999	85	43289											
SMTN	6525	broad.mit.edu	37	chr22	31491537	31491537	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctggatcagagcacggaCtttgaagagcggaagctcat	12	7	13	9	2	2	3	2	1	0	2	2	6	2	6	0	3	4	3	0	3	2	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr22:31491537C>A	uc003ajl.1	+	13	2021	c.1803C>A	c.(1801-1803)GAC>GAA	p.D601E	SMTN_uc003ajk.1_Missense_Mutation_p.D601E|SMTN_uc003ajm.1_Missense_Mutation_p.D601E|SMTN_uc011ale.1_Missense_Mutation_p.D686E|SMTN_uc011alf.1_Missense_Mutation_p.D657E|SMTN_uc003ajn.1_Missense_Mutation_p.D624E|SMTN_uc011alg.1_Missense_Mutation_p.D57E|SMTN_uc003ajo.1_Missense_Mutation_p.D200E|SMTN_uc011alh.1_RNA|SMTN_uc010gwe.1_Missense_Mutation_p.D57E	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	601					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						AGAGCACGGACTTTGAAGAGC	0.577													15	37					3.27435e-08	1.49165e-07	1	0	A	31491537	A	A	31491537	3	1	237	1	0	0	0	0	1	0	0	0	14878	564	20	4	1849	4	SMTN	22	31491537	Missense_Mutation	SNP	C	TCGA-CV-7247-01A-11D-2012-08		31491537	19813029	86	43290											
ACO2	50	broad.mit.edu	37	chr22	41919936	41919936	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagacccatgcctttgtcacGtccccagaggtgagactgcc	8	8	11	14	1	1	3	1	1	0	3	2	5	2	3	5	1	2	0	5	1	0	1	rs148997312		TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chr22:41919936G>A	uc003bac.2	+	12	1495	c.1473G>A	c.(1471-1473)ACG>ACA	p.T491T	ACO2_uc003bad.2_Silent_p.T516T	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	491					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						CCTTTGTCACGTCCCCAGAGG	0.617													9	33					0	0	0	0	A	41919936	A	A	41919936	2	1	237	1	0	0	0	0	0	0	0	1	147	1132	40	1		1	ACO2	22	41919936	Silent	SNP	G	TCGA-CV-7247-01A-11D-2012-08	10428399	41919936	9384630	87	43291											
FRMPD4	9758	broad.mit.edu	37	chrX	12734913	12734913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctgtctgggtcaagcgatGacatcattgacctcacatcc	10	10	8	13	1	4	2	3	2	1	0	5	3	5	2	3	1	1	0	3	1	1	1			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chrX:12734913G>A	uc004cuz.1	+	15	2841	c.2335G>A	c.(2335-2337)GAC>AAC	p.D779N	FRMPD4_uc011mij.1_Missense_Mutation_p.D771N	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	779					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						GTCAAGCGATGACATCATTGA	0.592													9	100					0	0	0	0	A	12734913	A	A	12734913	3	1	237	1	0	0	0	0	1	0	0	0	6093	1290	45	2	2393	2	FRMPD4	23	12734913	Missense_Mutation	SNP	G	TCGA-CV-7247-01A-11D-2012-08		12734913	142535647	88	43292											
GLOD5	392465	broad.mit.edu	37	chrX	48629492	48629492	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttggaggaaatgatccagcaCctcaaggtgagtgggacttc	11	9	13	8	0	1	2	1	2	0	0	3	5	2	5	2	4	1	1	2	4	2	2			TCGA-CV-7247-01A-11D-2012-08	TCGA-CV-7247-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0ce56d2-8e2b-42b4-ac59-d37ba5a7a2c3	60db65de-c75e-4f86-a87b-e6ffef420753	g.chrX:48629492C>T	uc011mmh.1	+	3	392	c.351C>T	c.(349-351)CAC>CAT	p.H117H		NM_001080489	NP_001073958			glyoxalase domain containing 5												0						TGATCCAGCACCTCAAGGTGA	0.483													18	10					0	0	0	0	T	48629492	T	T	48629492	2	4	237	1	0	0	0	0	0	0	0	1	6488	506	18	4		4	GLOD5	23	48629492	Silent	SNP	C	TCGA-CV-7247-01A-11D-2012-08	35894579	48629492	106641068	89	43293											
LOC440563	440563	broad.mit.edu	37	chr1	13183462	13183462	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgagggcactacagccagAgcaatgggaggaggaggagg	12	4	18	7	1	0	1	0	0	0	1	1	6	0	5	1	6	3	2	1	6	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:13183462A>G	uc010obg.1	-	1	506	c.411T>C	c.(409-411)GCT>GCC	p.A137A		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	137						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CTACAGCCAGAGCAATGGGAG	0.502													11	417					0	0	0	0	G	13183462	G	G	13183462	2	3	238	1	0	0	0	0	0	0	0	1	8928	291	11	5		5	LOC440563	1	13183462	Silent	SNP	A	TCGA-CV-7248-01A-11D-2012-08		13183462	236067159	1	43294											
PLA2G2E	30814	broad.mit.edu	37	chr1	20246801	20246801	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggaggccgagcatagcctCagcagggcggggtgggcccg	6	3	21	11	3	1	0	1	0	0	0	1	2	1	1	3	7	3	2	3	7	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:20246801C>T	uc001bct.1	-	4	486	c.428G>A	c.(427-429)TGA>TAA	p.*143*		NM_014589	NP_055404	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE precursor	143					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		AGCATAGCCTCAGCAGGGCGG	0.647													7	26					0	0	0	0	T	20246801	T	T	20246801	2	4	238	1	0	0	0	0	0	0	0	1	12053	840	29	2		2	PLA2G2E	1	20246801	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	7063339	20246801	229003820	2	43295											
E2F2	1870	broad.mit.edu	37	chr1	23850945	23850945	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggaactcagggacgacgggCctcccaatcccctccagatc	9	5	11	16	2	1	1	1	0	0	1	5	4	4	3	5	3	1	0	5	3	2	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:23850945C>G	uc001bhe.1	-	2	716	c.288G>C	c.(286-288)AGG>AGC	p.R96S	uc001bhf.1_5'Flank	NM_004091	NP_004082	Q14209	E2F2_HUMAN	E2F transcription factor 2	96	Cyclin A/CDK2 binding (Potential).				G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|skin(2)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		GGACGACGGGCCTCCCAATCC	0.572													5	34					0	0	0	0	G	23850945	G	G	23850945	3	3	238	1	0	0	0	0	1	0	0	0	4889	738	26	4	1049	4	E2F2	1	23850945	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3604144	23850945	225399676	3	43296											
RUNX3	864	broad.mit.edu	37	chr1	25228965	25228965	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tatggtggaagcggctggtgGccggcatgcccgccacgctg	5	7	17	12	4	0	0	0	0	0	0	0	1	0	1	3	6	2	3	3	6	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:25228965G>T	uc001bjq.2	-	5	1307	c.896C>A	c.(895-897)GCC>GAC	p.A299D	RUNX3_uc010oen.1_Missense_Mutation_p.A246D|RUNX3_uc009vrj.2_Missense_Mutation_p.A313D|RUNX3_uc001bjr.2_Missense_Mutation_p.A313D|RUNX3_uc001bjs.2_RNA	NM_004350	NP_004341	Q13761	RUNX3_HUMAN	runt-related transcription factor 3 isoform 2	299	Pro/Ser/Thr-rich.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		GCGGCTGGTGGCCGGCATGCC	0.701													12	58					5.50884e-06	6.5651e-06	1	0	T	25228965	T	T	25228965	3	4	238	1	0	0	0	0	1	0	0	0	13814	1203	42	4	355	4	RUNX3	1	25228965	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1378020	25228965	224021656	4	43297											
ZNF643	65243	broad.mit.edu	37	chr1	40928732	40928732	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acatgttagaattcataccgGggaaaagccctatgaatgta	15	10	9	7	1	1	2	1	1	0	1	1	3	1	3	2	2	2	2	2	2	8	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:40928732G>A	uc001cfn.1	+	5	1373	c.1076G>A	c.(1075-1077)GGG>GAG	p.G359E	ZNF643_uc001cfl.1_Missense_Mutation_p.G257E|ZNF643_uc001cfm.1_Missense_Mutation_p.G225E	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			ATTCATACCGGGGAAAAGCCC	0.423													6	43					0	0	0	0	A	40928732	A	A	40928732	3	1	238	1	0	0	0	0	1	0	0	0	18126	1232	43	4	1094	4	ZNF643	1	40928732	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	15699767	40928732	208321889	5	43298											
LRRIQ3	127255	broad.mit.edu	37	chr1	74507088	74507088	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaacgctctgaagccttttgGgatttttcttttagaaacag	11	15	8	7	1	2	2	0	1	2	1	2	3	2	3	1	1	3	1	1	1	4	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:74507088G>T	uc001dfy.3	-	7	1719	c.1527C>A	c.(1525-1527)TCC>TCA	p.S509S	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	509										ovary(2)	2						AAGCCTTTTGGGATTTTTCTT	0.363													7	96					2.7689e-08	3.57391e-08	1	0	T	74507088	T	T	74507088	2	4	238	1	0	0	0	0	0	0	0	1	9080	1219	43	4		4	LRRIQ3	1	74507088	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	33578356	74507088	174743533	6	43299											
LRRIQ3	127255	broad.mit.edu	37	chr1	74507545	74507545	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atgaacctgaagtgtatatgGgtagtttgaaaactgatatc	14	13	10	4	0	0	4	0	4	0	0	1	4	0	4	1	1	2	3	1	1	8	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:74507545G>T	uc001dfy.3	-	7	1262	c.1070C>A	c.(1069-1071)CCC>CAC	p.P357H	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	357										ovary(2)	2						AGTGTATATGGGTAGTTTGAA	0.338													4	39					2.56e-06	3.06896e-06	1	0	T	74507545	T	T	74507545	3	4	238	1	0	0	0	0	1	0	0	0	9080	1232	43	4	812	4	LRRIQ3	1	74507545	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	457	74507545	174743076	7	43300											
ZZZ3	26009	broad.mit.edu	37	chr1	78098771	78098771	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctatgttatccttttctgaaGaagaaagtcctcttttccta	10	17	5	9	0	2	3	0	1	2	2	5	3	5	3	3	0	0	1	3	0	6	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:78098771G>A	uc001dhq.2	-	5	745	c.269C>T	c.(268-270)TCT>TTT	p.S90F	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.S90F|ZZZ3_uc001dhp.2_Missense_Mutation_p.S90F	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						CTTTTCTGAAGAAGAAAGTCC	0.383													17	157					0	0	0	0	A	78098771	A	A	78098771	3	1	238	1	0	0	0	0	1	0	0	0	18323	942	33	2	2486	2	ZZZ3	1	78098771	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3591226	78098771	171151850	8	43301											
ELTD1	64123	broad.mit.edu	37	chr1	79470764	79470764	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcttgtttaccttcacaaaTtgtgacaccatttcctgaaa	12	14	5	10	0	1	2	1	2	0	0	2	2	2	2	3	0	2	2	3	0	3	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:79470764T>A	uc001diq.3	-	2	319	c.163A>T	c.(163-165)ATT>TTT	p.I55F		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	55	Extracellular (Potential).|EGF-like 1.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CCTTCACAAATTGTGACACCA	0.373													7	76					0	0	0	0	A	79470764	A	A	79470764	3	1	238	1	0	0	0	0	1	0	0	0	5108	1493	52	5	1965	5	ELTD1	1	79470764	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	1371993	79470764	169779857	9	43302											
COL24A1	255631	broad.mit.edu	37	chr1	86289270	86289270	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccctggtcacctggttcGccctttagtagaaaccaaaa	11	10	7	13	1	2	1	2	0	0	1	3	1	2	1	4	2	1	2	4	2	5	4	rs143522499	by1000genomes	TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:86289270G>T	uc001dlj.2	-	45	3780	c.3738C>A	c.(3736-3738)GGC>GGA	p.G1246G	COL24A1_uc001dli.2_Silent_p.G382G|COL24A1_uc010osd.1_Silent_p.G546G|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1246	Collagen-like 13.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CACCTGGTTCGCCCTTTAGTA	0.318													5	56					0.000602214	0.000668392	1	0	T	86289270	T	T	86289270	2	4	238	1	0	0	0	0	0	0	0	1	3698	1074	38	3		3	COL24A1	1	86289270	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	6818506	86289270	162961351	10	43303											
KCNA3	3738	broad.mit.edu	37	chr1	111217039	111217039	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatgcgccgcttggggtcGcccagcagcgtctcggggaa	5	7	15	14	5	2	0	1	0	1	0	4	1	2	1	2	4	3	2	2	4	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:111217039G>T	uc001dzv.1	-	1	617	c.393C>A	c.(391-393)GGC>GGA	p.G131G		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	131						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTTGGGGTCGCCCAGCAGCG	0.627													13	117					7.03913e-09	9.29349e-09	1	0	T	111217039	T	T	111217039	2	4	238	1	0	0	0	0	0	0	0	1	8043	1074	38	3		3	KCNA3	1	111217039	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	24927769	111217039	138033582	11	43304											
LOC200030	200030	broad.mit.edu	37	chr1	148346964	148346964	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caaaaacaaggttcaaggtgCctcaactcagagctgaaagc	16	6	9	10	0	3	2	3	1	0	1	3	2	3	2	1	2	5	2	1	2	6	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:148346964C>T	uc001eqe.2	-						LOC200030_uc001eqf.2_5'Flank|LOC200030_uc001eqg.2_5'Flank|NBPF14_uc009wkf.1_5'Flank|uc001erd.3_5'Flank|uc001erc.3_5'Flank|uc010paj.1_5'Flank|uc010pav.1_5'UTR|uc010paw.1_5'UTR			Q86T75	NBPFB_HUMAN	SubName: Full=cDNA FLJ78770;							cytoplasm					0						GTTCAAGGTGCCTCAACTCAG	0.463													3	3					0	0	0	0	T	148346964	T	T	148346964	1	4	238	0	1	0	0	0	0	0	0	0	8917	754	26	4		4	LOC200030	1	148346964	5'Flank	SNP	C	TCGA-CV-7248-01A-11D-2012-08	37129925	148346964	100903657	12	43305											
ADAMTSL4	54507	broad.mit.edu	37	chr1	150529140	150529140	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccatcatcaatgggaactgGgctgtggatccccctgggtc	7	10	12	12	0	2	0	2	0	0	0	5	2	4	2	3	4	1	1	3	4	2	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:150529140G>A	uc001eux.2	+	10	1856	c.1620G>A	c.(1618-1620)TGG>TGA	p.W540*	ADAMTSL4_uc001euw.2_Nonsense_Mutation_p.W540*|ADAMTSL4_uc009wlw.2_Nonsense_Mutation_p.W563*|ADAMTSL4_uc010pcg.1_Nonsense_Mutation_p.W563*|ADAMTSL4_uc009wlx.2_5'Flank	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	540					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			ATGGGAACTGGGCTGTGGATC	0.612													16	147					0	0	0	0	A	150529140	A	A	150529140	4	1	238	1	0	0	0	0	0	1	0	0	277	1241	43	4	1650	4	ADAMTSL4	1	150529140	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	2182176	150529140	98721481	13	43306											
HRNR	388697	broad.mit.edu	37	chr1	152191468	152191468	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccagagccatgtcggccgcgGcccgaagcgtgatgggaggc	7	4	17	13	5	0	2	0	1	0	1	1	4	0	3	4	4	2	0	4	4	1	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:152191468G>T	uc001ezt.1	-	3	2713	c.2637C>A	c.(2635-2637)GGC>GGA	p.G879G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	879	10.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCGGCCGCGGCCCGAAGCGT	0.622													48	90					3.77016e-25	5.81353e-25	1	0	T	152191468	T	T	152191468	2	4	238	1	0	0	0	0	0	0	0	1	7398	1190	42	4		4	HRNR	1	152191468	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1662328	152191468	97059153	14	43307											
SPTA1	6708	broad.mit.edu	37	chr1	158583633	158583633	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aactctttgtgagtcaggcgCcctgtcaaattctcatcaaa	11	12	7	11	1	5	1	4	1	2	0	6	1	5	1	1	1	1	0	1	1	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:158583633C>G	uc001fst.1	-	50	7066	c.6867G>C	c.(6865-6867)GGG>GGC	p.G2289G		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2289	EF-hand 1.|1 (Potential).				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GAGTCAGGCGCCCTGTCAAAT	0.408													14	29					0	0	0	0	G	158583633	G	G	158583633	2	3	238	1	0	0	0	0	0	0	0	1	15182	726	26	4		4	SPTA1	1	158583633	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	6392165	158583633	90666988	15	43308											
OR6K2	81448	broad.mit.edu	37	chr1	158669539	158669539	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgacctatgtgcttttttaTagcttcttttatttctttat	6	25	4	6	0	2	1	0	1	2	0	2	1	2	1	1	0	2	2	1	0	5	12			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:158669539T>A	uc001fsu.1	-	1	904	c.904A>T	c.(904-906)ATA>TTA	p.I302L		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TGCTTTTTTATAGCTTCTTTT	0.378													13	25					0	0	0	0	A	158669539	A	A	158669539	3	1	238	1	0	0	0	0	1	0	0	0	11256	1406	49	5	74	5	OR6K2	1	158669539	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	85906	158669539	90581082	16	43309											
NMNAT2	23057	broad.mit.edu	37	chr1	183387391	183387391	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagataacgtgggtcttggtGgtctcggtcatggtgcagat	8	12	15	6	2	3	2	1	0	2	2	4	2	3	2	0	5	2	1	0	5	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:183387391G>C	uc001gqc.1	-	1	347	c.12C>G	c.(10-12)ACC>ACG	p.T4T		NM_015039	NP_055854	Q9BZQ4	NMNA2_HUMAN	nicotinamide mononucleotide adenylyltransferase	4					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			skin(1)	1						GGGTCTTGGTGGTCTCGGTCA	0.567													48	93					0	0	0	0	C	183387391	C	C	183387391	2	2	238	1	0	0	0	0	0	0	0	1	10553	1335	47	4		4	NMNAT2	1	183387391	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	24717852	183387391	65863230	17	43310											
LHX9	56956	broad.mit.edu	37	chr1	197898131	197898131	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaattgggattggtttgcaGgtttggttccaaaacgcacg	9	13	12	7	2	1	0	1	0	0	0	2	1	2	1	1	4	2	5	1	4	3	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:197898131G>C	uc001guk.1	+	5	1374	c.937_splice	c.e5-1	p.V313_splice	LHX9_uc001gui.1_Splice_Site_p.V304_splice|LHX9_uc001guj.1_Intron	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1						motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						TTGGTTTGCAGGTTTGGTTCC	0.353													20	22					0	0	0	0	C	197898131	C	C	197898131	5	2	238	1	0	0	0	0	0	0	1	0	8818	1014	35	4	986	4	LHX9	1	197898131	Splice_Site	SNP	G	TCGA-CV-7248-01A-11D-2012-08	14510740	197898131	51352490	18	43311											
CACNA1S	779	broad.mit.edu	37	chr1	201047133	201047133	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaccacgaagcagtcgaagCggttgaagatagacatgaag	16	5	12	8	3	0	4	0	2	0	2	1	6	0	4	1	1	2	2	1	1	5	2	rs150590855	byFrequency	TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:201047133C>A	uc001gvv.2	-	11	1720	c.1493G>T	c.(1492-1494)CGC>CTC	p.R498L		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	498	Helical; Name=S3 of repeat II; (Potential).|II.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GCAGTCGAAGCGGTTGAAGAT	0.592													39	74					5.44703e-19	8.15037e-19	1	0	A	201047133	A	A	201047133	3	1	238	1	0	0	0	0	1	0	0	0	2559	768	27	3	4264	3	CACNA1S	1	201047133	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3149002	201047133	48203488	19	43312											
OR2L13	284521	broad.mit.edu	37	chr1	248262829	248262829	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattcacctcatccacgtggAtcctcgtctccacacaccga	9	9	6	17	3	3	0	2	0	1	0	7	3	5	1	5	1	0	0	5	1	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:248262829A>G	uc001ids.2	+	3	489	c.152A>G	c.(151-153)GAT>GGT	p.D51G		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ATCCACGTGGATCCTCGTCTC	0.502													6	151					0	0	0	0	G	248262829	G	G	248262829	3	3	238	1	0	0	0	0	1	0	0	0	11060	333	12	5	154	5	OR2L13	1	248262829	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	47215696	248262829	987792	20	43313											
OR2T33	391195	broad.mit.edu	37	chr1	248436759	248436759	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggcagacagccgcatagcGgtcataggccatggctgcta	9	7	14	11	2	1	1	1	0	0	1	1	1	1	1	2	4	3	4	2	4	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr1:248436759G>T	uc010pzi.1	-	1	358	c.358C>A	c.(358-360)CGC>AGC	p.R120S		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCCGCATAGCGGTCATAGGCC	0.592													21	95					2.85442e-18	4.25529e-18	1	0	T	248436759	T	T	248436759	3	4	238	1	0	0	0	0	1	0	0	0	11078	1116	39	3	607	3	OR2T33	1	248436759	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	173930	248436759	813862	21	43314											
ITSN2	50618	broad.mit.edu	37	chr2	24484540	24484540	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttttctacataattgcaTggaaaccagccaaaatttcc	14	14	4	9	0	1	0	0	0	1	0	2	1	2	1	3	1	4	1	3	1	5	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:24484540T>A	uc002rfe.2	-	21	2685	c.2427A>T	c.(2425-2427)CCA>CCT	p.P809P	ITSN2_uc002rff.2_Silent_p.P782P|ITSN2_uc002rfg.2_Silent_p.P809P	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	809	SH3 1.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATAATTGCATGGAAACCAGC	0.368													7	37					0	0	0	0	A	24484540	A	A	24484540	2	1	238	1	0	0	0	0	0	0	0	1	7966	1451	51	5		5	ITSN2	2	24484540	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08		24484540	218714833	22	43315											
OTOF	9381	broad.mit.edu	37	chr2	26687858	26687858	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagaggcgggtcaggatctgGctgggcttcatggggtcccg	5	8	18	10	2	3	1	2	0	1	1	4	2	4	2	1	7	0	2	1	7	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:26687858G>A	uc002rhk.2	-	39	4966	c.4839C>T	c.(4837-4839)AGC>AGT	p.S1613S	OTOF_uc010yla.1_Silent_p.S343S|OTOF_uc002rhh.2_Silent_p.S846S|OTOF_uc002rhi.2_Silent_p.S923S|OTOF_uc002rhj.2_Silent_p.S846S	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1613	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCAGGATCTGGCTGGGCTTCA	0.627													8	45					0	0	0	0	A	26687858	A	A	26687858	2	1	238	1	0	0	0	0	0	0	0	1	11357	1194	42	4		4	OTOF	2	26687858	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	2203318	26687858	216511515	23	43316											
NRBP1	29959	broad.mit.edu	37	chr2	27663754	27663754	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggtgacatcacctgtcgtgCccccctctgtcaagactccg	7	9	9	16	2	3	2	2	1	1	1	5	2	4	2	5	1	1	0	5	1	1	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:27663754C>T	uc002rko.2	+	15	2108	c.1276C>T	c.(1276-1278)CCC>TCC	p.P426S	NRBP1_uc002rkq.2_Missense_Mutation_p.P425S|NRBP1_uc002rkp.2_Missense_Mutation_p.P426S|NRBP1_uc002rkr.2_Missense_Mutation_p.P217S|KRTCAP3_uc002rks.2_5'Flank|KRTCAP3_uc010ylr.1_5'Flank|KRTCAP3_uc002rkt.2_5'Flank	NM_013392	NP_037524	Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein	426					ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			ovary(2)|lung(1)	3	Acute lymphoblastic leukemia(172;0.155)					ACCTGTCGTGCCCCCCTCTGT	0.602													12	76					0	0	0	0	T	27663754	T	T	27663754	3	4	238	1	0	0	0	0	1	0	0	0	10696	739	26	4	1326	4	NRBP1	2	27663754	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	975896	27663754	215535619	24	43317											
EHD3	30845	broad.mit.edu	37	chr2	31483477	31483477	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatctctgatgagttctcaGaagtcatcaaagccctcaag	13	10	7	11	0	5	3	4	2	2	1	7	3	5	3	1	0	1	1	1	0	3	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:31483477G>T	uc002rnu.2	+	4	1212	c.604G>T	c.(604-606)GAA>TAA	p.E202*	EHD3_uc010ymt.1_Intron	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	202	Potential.				blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					TGAGTTCTCAGAAGTCATCAA	0.537													17	39					1.99824e-07	2.49934e-07	1	0	T	31483477	T	T	31483477	4	4	238	1	0	0	0	0	0	1	0	0	5001	943	33	2	618	2	EHD3	2	31483477	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3819723	31483477	211715896	25	43318											
XDH	7498	broad.mit.edu	37	chr2	31598336	31598336	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtgcaccggaagtccacCatgccaccaggggcatcggg	9	4	15	13	2	0	0	0	0	0	0	2	1	1	1	5	5	2	2	5	5	1	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:31598336C>A	uc002rnv.1	-	15	1591	c.1512G>T	c.(1510-1512)ATG>ATT	p.M504I		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	504					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GGAAGTCCACCATGCCACCAG	0.607													20	72					1.56452e-12	2.19468e-12	1	0	A	31598336	A	A	31598336	3	1	238	1	0	0	0	0	1	0	0	0	17494	594	21	4	2577	4	XDH	2	31598336	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	114859	31598336	211601037	26	43319											
VIT	5212	broad.mit.edu	37	chr2	36982161	36982161	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaacggtgtccaatcgttaTccctaccacgatggagagaa	12	8	9	12	3	0	1	0	0	0	1	3	4	2	2	4	2	2	1	4	2	5	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:36982161T>G	uc002rpl.2	+	5	594	c.373T>G	c.(373-375)TCC>GCC	p.S125A	VIT_uc002rpk.2_Missense_Mutation_p.S118A|VIT_uc010ynf.1_Missense_Mutation_p.S118A|VIT_uc002rpm.2_Missense_Mutation_p.S118A|VIT_uc010ezv.2_Missense_Mutation_p.S118A|VIT_uc010ezw.2_Missense_Mutation_p.S118A	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	125	LCCL.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				CCAATCGTTATCCCTACCACG	0.438													5	32					0	0	0	0	G	36982161	G	G	36982161	3	3	238	1	0	0	0	0	1	0	0	0	17239	1435	50	5	387	5	VIT	2	36982161	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	5383825	36982161	206217212	27	43320											
EPAS1	2034	broad.mit.edu	37	chr2	46574098	46574098	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggaggtgttctatgagctggCccatgagctgcctctgcccc	5	10	13	13	0	2	2	0	2	2	0	2	3	2	3	4	3	4	3	4	3	1	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:46574098C>T	uc002ruv.2	+	2	601	c.113C>T	c.(112-114)GCC>GTC	p.A38V		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	38	Helix-loop-helix motif.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			TATGAGCTGGCCCATGAGCTG	0.602													14	107					0	0	0	0	T	46574098	T	T	46574098	3	4	238	1	0	0	0	0	1	0	0	0	5174	739	26	4	119	4	EPAS1	2	46574098	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	9591937	46574098	196625275	28	43321											
PSME4	23198	broad.mit.edu	37	chr2	54117299	54117299	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctacggtaatattggacAgtgctgttctaagcagaggg	10	13	12	6	1	2	1	0	0	2	1	2	2	2	2	0	3	3	4	0	3	4	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:54117299A>T	uc002rxp.2	-	37	4294	c.4238T>A	c.(4237-4239)CTG>CAG	p.L1413Q	PSME4_uc010yop.1_Missense_Mutation_p.L1299Q|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Missense_Mutation_p.L788Q|PSME4_uc010fbv.1_Missense_Mutation_p.L557Q|PSME4_uc010fbt.1_5'Flank	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1413					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AATATTGGACAGTGCTGTTCT	0.388													26	119					0	0	0	0	T	54117299	T	T	54117299	3	4	238	1	0	0	0	0	1	0	0	0	12771	188	7	5	1333	5	PSME4	2	54117299	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	7543201	54117299	189082074	29	43322											
CLEC4F	165530	broad.mit.edu	37	chr2	71043258	71043258	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttaacctctggatctcggCactggccttctgcagattgc	6	13	9	13	1	4	1	0	0	4	1	5	2	4	2	2	3	3	2	2	3	1	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:71043258C>A	uc002shf.2	-	4	1332	c.1255G>T	c.(1255-1257)GCC>TCC	p.A419S	CLEC4F_uc010yqv.1_Missense_Mutation_p.A419S	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	419	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						TGGATCTCGGCACTGGCCTTC	0.498													9	34					7.48243e-07	9.13263e-07	1	0	A	71043258	A	A	71043258	3	1	238	1	0	0	0	0	1	0	0	0	3531	710	25	4	530	4	CLEC4F	2	71043258	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	16925959	71043258	172156115	30	43323											
REG3G	130120	broad.mit.edu	37	chr2	79255021	79255021	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaaaaatccctccaccatctTaaaccctggccactgtggga	12	8	7	14	0	1	0	0	0	1	0	3	2	3	1	5	2	1	0	5	2	4	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:79255021T>A	uc002snw.2	+	5	507	c.422T>A	c.(421-423)TTA>TAA	p.L141*	REG3G_uc002snx.2_Nonsense_Mutation_p.L141*|REG3G_uc010ffu.2_Nonsense_Mutation_p.L95*	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	141	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						TCCACCATCTTAAACCCTGGC	0.498													20	94					0	0	0	0	A	79255021	A	A	79255021	4	1	238	1	0	0	0	0	0	1	0	0	13278	1764	61	5	436	5	REG3G	2	79255021	Nonsense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	8211763	79255021	163944352	31	43324											
RPIA	22934	broad.mit.edu	37	chr2	88991474	88991474	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggccaagaagctggcgggCcgcgcggctgtggagaacca	9	3	18	11	4	0	2	0	0	0	2	0	4	0	2	3	5	2	2	3	5	3	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:88991474C>T	uc002ste.2	+	1	299	c.258C>T	c.(256-258)GGC>GGT	p.G86G		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	86					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				AGCTGGCGGGCCGCGCGGCTG	0.672													5	15					0	0	0	0	T	88991474	T	T	88991474	2	4	238	1	0	0	0	0	0	0	0	1	13618	726	26	4		4	RPIA	2	88991474	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	9736453	88991474	154207899	32	43325											
KIAA1310	55683	broad.mit.edu	37	chr2	97278597	97278597	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gattgccagaagcggtggcgGcgtgaagtgggaaacacaga	12	5	17	7	3	0	3	0	1	0	2	0	5	0	4	1	4	3	0	1	4	3	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr2:97278597G>A	uc002swn.3	-	7	1016	c.870C>T	c.(868-870)CGC>CGT	p.R290R	KIAA1310_uc002swh.3_Silent_p.R178R|KIAA1310_uc002swi.3_Silent_p.R191R|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Silent_p.R203R|KIAA1310_uc010fhz.2_Silent_p.R84R|KIAA1310_uc002swl.3_Silent_p.R191R|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Silent_p.R84R|KIAA1310_uc002swp.1_Silent_p.R191R|KIAA1310_uc002swq.1_Silent_p.R62R|KIAA1310_uc010fhy.1_Silent_p.R191R	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	290											0						AGCGGTGGCGGCGTGAAGTGG	0.552													3	4					0	0	0	0	A	97278597	A	A	97278597	2	1	238	1	0	0	0	0	0	0	0	1	8261	1190	42	4		4	KIAA1310	2	97278597	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	8287123	97278597	145920776	33	43326											
SLC9A4	389015	broad.mit.edu	37	chr2	103136343	103136343	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaggatacaaggaatcaaaAgactttcccctgaagatgtg	16	8	10	7	0	1	4	1	1	0	3	2	6	2	6	2	2	1	0	2	2	6	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:103136343A>G	uc002tbz.3	+	9	2204	c.1747A>G	c.(1747-1749)AGA>GGA	p.R583G		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	583	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						AGGAATCAAAAGACTTTCCCC	0.458													10	24					0	0	0	0	G	103136343	G	G	103136343	3	3	238	1	0	0	0	0	1	0	0	0	14780	64	3	5	1781	5	SLC9A4	2	103136343	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	5857746	103136343	140063030	34	43327											
UGGT1	56886	broad.mit.edu	37	chr2	128937402	128937402	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaataccaagactcctgtGaaattctggttcttgaagaa	15	11	8	7	0	2	5	0	2	2	3	3	5	3	5	2	1	1	1	2	1	7	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:128937402G>C	uc002tps.2	+	35	4036	c.3858G>C	c.(3856-3858)GTG>GTC	p.V1286V	UGGT1_uc002tpr.2_Silent_p.V1262V	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1286	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						AGACTCCTGTGAAATTCTGGT	0.343													11	53					0	0	0	0	C	128937402	C	C	128937402	2	2	238	1	0	0	0	0	0	0	0	1	17009	1277	45	2		2	UGGT1	2	128937402	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	25801059	128937402	114261971	35	43328											
SMPD4	55627	broad.mit.edu	37	chr2	130918826	130918826	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcgctggagacactgagtCggtagtgcagaacctccagc	9	6	15	11	2	0	3	0	1	0	2	2	4	1	3	2	3	3	3	2	3	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:130918826C>A	uc002tqq.1	-	11	1521	c.1001G>T	c.(1000-1002)CGA>CTA	p.R334L	SMPD4_uc002tqp.1_Missense_Mutation_p.R27L|SMPD4_uc010yzy.1_Intron|SMPD4_uc010yzz.1_Intron|SMPD4_uc002tqr.1_Intron|SMPD4_uc002tqs.1_Missense_Mutation_p.R202L|SMPD4_uc002tqt.1_Intron|SMPD4_uc010zaa.1_Intron|SMPD4_uc010zab.1_Intron|SMPD4_uc010zac.1_Missense_Mutation_p.D48Y|SMPD4_uc010zad.1_Intron	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	295					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GACACTGAGTCGGTAGTGCAG	0.597													15	58					2.31682e-05	2.70519e-05	1	0	A	130918826	A	A	130918826	3	1	238	1	0	0	0	0	1	0	0	0	14871	884	31	3	1639	3	SMPD4	2	130918826	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1981424	130918826	112280547	36	43329											
NCKAP5	344148	broad.mit.edu	37	chr2	133541907	133541907	+	Frame_Shift_Del	DEL	G	-	-																															gagtcaccaggccagatgaaGggagtagtgtggtggcttcg																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:133541907delG	uc002ttp.2	-	14	2851	c.2477delC	c.(2476-2478)CCTfs	p.P826fs	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	826							protein binding				0						GCCAGATGAAGGGAGTAGTGT	0.473													---	---	---								-	133541907	-	-	133541907	7	5	238	1	0	1	0	1	0	0	0	0	10277	1000	35	0	3280	0	NCKAP5	2	133541907	Frame_Shift_Del	DEL	G	TCGA-CV-7248-01A-11D-2012-08	2623081	133541907	109657466	37	43330											
ZEB2	9839	broad.mit.edu	37	chr2	145156365	145156366	+	Missense_Mutation	DNP	GG	TT	TT																															tggagtgtatgaactactgtGggagtttttagaagatgtgg																								rs111359671		TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:145156365_145156366GG>TT	uc002tvu.2	-	8	2868_2869	c.2388_2389CC>AA	c.(2386-2391)TCCCAC>TCAAAC	p.H797N	ZEB2_uc002tvv.2_Missense_Mutation_p.H791N|ZEB2_uc010zbm.1_Missense_Mutation_p.H768N|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.H826N	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	797						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GAACTACTGTGGGAGTTTTTAG	0.396													20	140					0	0	0	0	TT	145156366	TT	TT	145156365	3	4	238	1	0	0	0	0	1	0	0	0	17691	1348	47	4	1267	4	ZEB2	2	145156365	Missense_Mutation	DNP	GG	TCGA-CV-7248-01A-11D-2012-08	11614458	145156365	98043008	38	43331											
KCNH7	90134	broad.mit.edu	37	chr2	163695000	163695000	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccccagaaatgtattttgtGgtgccacatgccccctgcgc	7	11	9	14	1	0	1	0	0	0	1	1	1	1	1	5	1	3	1	5	1	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:163695000G>T	uc002uch.1	-	1	241	c.29C>A	c.(28-30)CCA>CAA	p.P10Q	KCNH7_uc002uci.2_Missense_Mutation_p.P10Q	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	10	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TGTATTTTGTGGTGCCACATG	0.562													14	56					2.48551e-13	3.53572e-13	1	0	T	163695000	T	T	163695000	3	4	238	1	0	0	0	0	1	0	0	0	8076	1348	47	4	3691	4	KCNH7	2	163695000	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	18538635	163695000	79504373	39	43332											
SCN7A	6332	broad.mit.edu	37	chr2	167279890	167279890	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagatcatgtcagcatatTctaataaaattttaattgtc	16	16	4	5	0	3	1	2	0	1	1	4	1	3	1	0	0	1	1	0	0	7	8			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:167279890T>G	uc002udu.1	-	18	3033	c.2906A>C	c.(2905-2907)GAA>GCA	p.E969A	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	969	Helical; Name=S2 of repeat III; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						GTCAGCATATTCTAATAAAAT	0.308													6	22					0	0	0	0	G	167279890	G	G	167279890	3	3	238	1	0	0	0	0	1	0	0	0	13988	1783	62	5	2174	5	SCN7A	2	167279890	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	3584890	167279890	75919483	40	43333											
SCN7A	6332	broad.mit.edu	37	chr2	167301445	167301445	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaacagggagaacaattccAgatcaagaaagttttagcaa	18	7	8	8	0	1	3	1	0	0	3	2	4	2	3	2	1	3	2	2	1	7	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:167301445A>T	uc002udu.1	-	12	1580	c.1453T>A	c.(1453-1455)TGG>AGG	p.W485R	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	485					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						GAACAATTCCAGATCAAGAAA	0.294													9	25					0	0	0	0	T	167301445	T	T	167301445	3	4	238	1	0	0	0	0	1	0	0	0	13988	188	7	5	3651	5	SCN7A	2	167301445	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	21555	167301445	75897928	41	43334											
TTN	7273	broad.mit.edu	37	chr2	179423146	179423146	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgattttcagcaaacactcGgaaaaagtattcagaattct	15	13	6	7	1	3	2	2	1	1	1	4	3	3	3	0	1	2	2	0	1	5	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:179423146G>T	uc010zfg.1	-	276	79560	c.79336C>A	c.(79336-79338)CGA>AGA	p.R26446R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.R20141R|TTN_uc010zfi.1_Silent_p.R20074R|TTN_uc010zfj.1_Silent_p.R19949R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27373							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAAACACTCGGAAAAAGTAT	0.423													10	32					2.74318e-10	3.71894e-10	1	0	T	179423146	T	T	179423146	2	4	238	1	0	0	0	0	0	0	0	1	16803	1124	39	3		3	TTN	2	179423146	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	12121701	179423146	63776227	42	43335											
TTN	7273	broad.mit.edu	37	chr2	179431634	179431634	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaccatcactatctggacGgttccaacagacggtcatgg	10	9	9	13	2	3	1	2	0	1	1	5	2	5	2	3	4	1	1	3	4	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:179431634G>T	uc010zfg.1	-	275	71745	c.71521C>A	c.(71521-71523)CGT>AGT	p.R23841S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R17536S|TTN_uc010zfi.1_Missense_Mutation_p.R17469S|TTN_uc010zfj.1_Missense_Mutation_p.R17344S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24768							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTATCTGGACGGTTCCAACAG	0.413													27	78					3.73808e-20	5.65612e-20	1	0	T	179431634	T	T	179431634	3	4	238	1	0	0	0	0	1	0	0	0	16803	1116	39	3	28902	3	TTN	2	179431634	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	8488	179431634	63767739	43	43336											
TTN	7273	broad.mit.edu	37	chr2	179483207	179483207	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cacttctaagttacgtactgGcccaggaacatctgaaattc	12	11	7	11	1	2	1	0	1	2	0	3	2	2	2	1	2	3	2	1	2	5	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:179483207G>T	uc010zfg.1	-	201	39498	c.39274C>A	c.(39274-39276)CCA>ACA	p.P13092T	TTN_uc010zfh.1_Missense_Mutation_p.P6787T|TTN_uc010zfi.1_Missense_Mutation_p.P6720T|TTN_uc010zfj.1_Missense_Mutation_p.P6595T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14019							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACGTACTGGCCCAGGAACA	0.403													22	67					1.28384e-07	1.6158e-07	1	0	T	179483207	T	T	179483207	3	4	238	1	0	0	0	0	1	0	0	0	16803	1203	42	4	61159	4	TTN	2	179483207	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	51573	179483207	63716166	44	43337											
TTN	7273	broad.mit.edu	37	chr2	179585700	179585700	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccaacaccattatgagcCtcacaaatgtagtccccgct	12	9	5	15	1	2	1	2	1	0	0	3	1	3	1	5	0	2	2	5	0	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:179585700C>A	uc010zfg.1	-	76	19538	c.19314G>T	c.(19312-19314)GAG>GAT	p.E6438D	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E3099D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7365							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTATGAGCCTCACAAATGT	0.428													8	74					1.12685e-05	1.33504e-05	1	0	A	179585700	A	A	179585700	3	1	238	1	0	0	0	0	1	0	0	0	16803	680	24	4	81619	4	TTN	2	179585700	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	102493	179585700	63613673	45	43338											
ZNF804A	91752	broad.mit.edu	37	chr2	185803441	185803441	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactgttttgcagcagcaCgctgcagctgctgcagctgc	7	9	11	14	1	0	0	0	0	0	0	0	0	0	0	0	0	9	10	0	0	0	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:185803441C>T	uc002uph.2	+	4	3912	c.3318C>T	c.(3316-3318)CAC>CAT	p.H1106H		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1106						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						tgcagcagcacgctgcagctg	0.373													14	93					0	0	0	0	T	185803441	T	T	185803441	2	4	238	1	0	0	0	0	0	0	0	1	18237	535	19	1		1	ZNF804A	2	185803441	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	6217741	185803441	57395932	46	43339											
ZSWIM2	151112	broad.mit.edu	37	chr2	187702117	187702117	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagtctctctttttctgctGcagctactagtttgctagag	6	16	8	11	0	3	1	0	0	3	1	4	1	3	1	1	0	5	5	1	0	3	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:187702117G>T	uc002upu.1	-	5	699	c.659C>A	c.(658-660)GCA>GAA	p.A220E		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	220					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TTTTTCTGCTGCAGCTACTAG	0.393													25	58					5.45024e-15	7.83593e-15	1	0	T	187702117	T	T	187702117	3	4	238	1	0	0	0	0	1	0	0	0	18308	1319	46	4	1262	4	ZSWIM2	2	187702117	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1898676	187702117	55497256	47	43340											
ZSWIM2	151112	broad.mit.edu	37	chr2	187703819	187703819	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	attttcgtcatttgttcctgGttggggagtttgaactcgat	6	18	11	6	2	1	1	1	1	0	0	4	3	2	2	1	3	1	3	1	3	1	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:187703819G>T	uc002upu.1	-	4	401	c.361C>A	c.(361-363)CCA>ACA	p.P121T		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	121					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TTTGTTCCTGGTTGGGGAGTT	0.403													44	201					4.67007e-22	7.09288e-22	1	0	T	187703819	T	T	187703819	3	4	238	1	0	0	0	0	1	0	0	0	18308	1261	44	4	1564	4	ZSWIM2	2	187703819	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1702	187703819	55495554	48	43341											
PMS1	5378	broad.mit.edu	37	chr2	190718963	190718963	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttgttaatttgtatttttAggaatctgttttaattgctc	9	23	6	3	0	1	0	0	0	1	0	2	1	1	1	0	1	1	4	0	1	5	10			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:190718963A>G	uc002urh.3	+	9	1496	c.967_splice	c.e9-2	p.E323_splice	PMS1_uc010zga.1_Splice_Site_p.E284_splice|PMS1_uc010zgb.1_Splice_Site_p.E262_splice|PMS1_uc002urk.3_Splice_Site_p.E284_splice|PMS1_uc002uri.3_Splice_Site_p.E323_splice|PMS1_uc010zgc.1_Splice_Site_p.E147_splice|PMS1_uc010zgd.1_Splice_Site_p.E147_splice|PMS1_uc002urj.2_Splice_Site|PMS1_uc010fry.1_Splice_Site_p.E284_splice|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Splice_Site_p.E108_splice|PMS1_uc002urm.2_Splice_Site|PMS1_uc002urn.1_Splice_Site	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a						mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			TTGTATTTTTAGGAATCTGTT	0.219			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					4	30					0	0	0	0	G	190718963	G	G	190718963	5	3	238	1	0	0	0	0	0	0	1	0	12197	434	15	5	995	5	PMS1	2	190718963	Splice_Site	SNP	A	TCGA-CV-7248-01A-11D-2012-08	3015144	190718963	52480410	49	43342											
DNAH7	56171	broad.mit.edu	37	chr2	196825534	196825534	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggcccttctgtccatgctcTatagttgctgctaaattcga	7	15	8	11	1	2	0	0	0	2	0	4	1	3	0	2	1	3	4	2	1	4	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:196825534T>C	uc002utj.3	-	18	2442	c.2341A>G	c.(2341-2343)AGA>GGA	p.R781G		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	781	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GTCCATGCTCTATAGTTGCTG	0.383													32	122					0	0	0	0	C	196825534	C	C	196825534	3	2	238	1	0	0	0	0	1	0	0	0	4628	1530	53	5	9925	5	DNAH7	2	196825534	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	6106571	196825534	46373839	50	43343											
PIKFYVE	200576	broad.mit.edu	37	chr2	209207340	209207340	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcccattgcagtctgcgagaAggaacccagctccatcattg	10	8	10	13	1	2	1	1	0	1	1	3	3	3	2	3	1	4	2	3	1	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:209207340A>G	uc002vcz.2	+	32	5152	c.4994A>G	c.(4993-4995)AAG>AGG	p.K1665R		NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1665					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GTCTGCGAGAAGGAACCCAGC	0.343													10	51					0	0	0	0	G	209207340	G	G	209207340	3	3	238	1	0	0	0	0	1	0	0	0	11979	72	3	5	5127	5	PIKFYVE	2	209207340	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	12381806	209207340	33992033	51	43344											
MAP2	4133	broad.mit.edu	37	chr2	210559961	210559961	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agaagggtcttagttcagtgCcagagatagctgaggtagaa	13	9	14	5	0	2	4	1	1	1	3	2	5	2	4	1	2	2	3	1	2	5	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:210559961C>T	uc002vde.1	+	7	3315	c.3067C>T	c.(3067-3069)CCA>TCA	p.P1023S	MAP2_uc002vdc.1_Missense_Mutation_p.P1023S|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.P1019S	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1023					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TAGTTCAGTGCCAGAGATAGC	0.428													6	38					0	0	0	0	T	210559961	T	T	210559961	3	4	238	1	0	0	0	0	1	0	0	0	9288	739	26	4	3081	4	MAP2	2	210559961	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1352621	210559961	32639412	52	43345											
ABCA12	26154	broad.mit.edu	37	chr2	215880266	215880266	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagaagggtgagtccgatgAggtaagactgccgggatctc	10	7	16	8	2	1	4	0	2	1	2	3	6	2	5	2	3	1	2	2	3	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:215880266A>T	uc002vew.2	-	15	2124	c.1904T>A	c.(1903-1905)CTC>CAC	p.L635H	ABCA12_uc002vev.2_Missense_Mutation_p.L317H|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	635					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GAGTCCGATGAGGTAAGACTG	0.383													5	27					0	0	0	0	T	215880266	T	T	215880266	3	4	238	1	0	0	0	0	1	0	0	0	30	304	11	5	6039	5	ABCA12	2	215880266	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	5320305	215880266	27319107	53	43346											
COL6A3	1293	broad.mit.edu	37	chr2	238242141	238242141	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctcaccattagattgatggTtgaactagaagctgaccttg	11	12	10	8	0	1	5	1	3	0	2	1	5	1	5	2	1	2	3	2	1	4	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:238242141T>C	uc002vwl.2	-	42	9565	c.9280A>G	c.(9280-9282)ACC>GCC	p.T3094A	COL6A3_uc002vwo.2_Missense_Mutation_p.T2888A|COL6A3_uc010znj.1_Missense_Mutation_p.T2487A|COL6A3_uc002vwj.2_Missense_Mutation_p.T475A	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	3094	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGATTGATGGTTGAACTAGAA	0.423													13	65					0	0	0	0	C	238242141	C	C	238242141	3	2	238	1	0	0	0	0	1	0	0	0	3716	1725	60	5	265	5	COL6A3	2	238242141	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	22361875	238242141	4957232	54	43347											
FARP2	9855	broad.mit.edu	37	chr2	242373725	242373726	+	Frame_Shift_Ins	INS	-	T	T																															tcttcagccggggctcctccINSttcagatacaggtaggggcc																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr2:242373725_242373726insT	uc002wbi.1	+	10	1137_1138	c.1020_1021insT	c.(1018-1023)TCCTTCfs	p.S340fs	FARP2_uc010zoq.1_Frame_Shift_Ins_p.S340fs|FARP2_uc010zor.1_Frame_Shift_Ins_p.S340fs	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	340_341					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GGGGCTCCTCCTTCAGATACAG	0.46													---	---	---								T	242373726	T	T	242373725	7	5	238	1	0	1	1	0	0	0	0	0	5709	668	24	0	1054	0	FARP2	2	242373725	Frame_Shift_Ins	INS	-	TCGA-CV-7248-01A-11D-2012-08	4131584	242373725	825648	55	43348											
FBLN2	2199	broad.mit.edu	37	chr3	13670762	13670762	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgactgcaaagccggctttCagcgggatgcctttggccgg	6	9	15	11	3	1	1	1	1	0	0	1	2	1	2	3	4	4	2	3	4	1	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:13670762C>T	uc011avb.1	+	12	2796	c.2671C>T	c.(2671-2673)CAG>TAG	p.Q891*	FBLN2_uc011auz.1_Nonsense_Mutation_p.Q917*|FBLN2_uc011ava.1_Nonsense_Mutation_p.Q938*|FBLN2_uc011avc.1_Nonsense_Mutation_p.Q938*	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	891	EGF-like 6; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGCCGGCTTTCAGCGGGATGC	0.642													7	18					0	0	0	0	T	13670762	T	T	13670762	4	4	238	1	0	0	0	0	0	1	0	0	5731	827	29	2	1548	2	FBLN2	3	13670762	Nonsense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08		13670762	184351668	56	43349											
CYP8B1	1582	broad.mit.edu	37	chr3	42917227	42917227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agggggctcccatggcctgcGttgtcggagcatccctggca	5	8	15	13	2	0	0	0	0	0	0	3	1	2	1	3	5	2	4	3	5	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr3:42917227G>A	uc003cmh.2	-	1	407	c.82C>T	c.(82-84)CGC>TGC	p.R28C	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Missense_Mutation_p.R28C	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	28					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CATGGCCTGCGTTGTCGGAGC	0.582													4	51					0	0	0	0	A	42917227	A	A	42917227	3	1	238	1	0	0	0	0	1	0	0	0	4215	1145	40	1	1427	1	CYP8B1	3	42917227	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	29246465	42917227	155105203	57	43350											
C3orf23	285343	broad.mit.edu	37	chr3	44442777	44442777	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcaaatctccagtggtttAttctcaccaaagctcagcag	12	10	7	12	0	3	0	2	0	2	0	5	0	3	0	2	1	3	4	2	1	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:44442777A>G	uc010him.2	+	10	1446	c.1201A>G	c.(1201-1203)ATT>GTT	p.I401V	C3orf23_uc003cnd.3_Missense_Mutation_p.I401V|C3orf23_uc003cne.3_Missense_Mutation_p.I257V	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	401						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		CCAGTGGTTTATTCTCACCAA	0.393													11	37					0	0	0	0	G	44442777	G	G	44442777	3	3	238	1	0	0	0	0	1	0	0	0	2226	449	16	5	1287	5	C3orf23	3	44442777	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	1525550	44442777	153579653	58	43351											
WNT5A	7474	broad.mit.edu	37	chr3	55513456	55513456	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttcgcgccttctccgaTgtactgcatgtggtcctgat	4	15	10	12	3	2	1	0	1	2	0	5	2	3	1	3	1	2	2	3	1	1	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:55513456T>C	uc003dhn.2	-	3	595	c.277A>G	c.(277-279)ATC>GTC	p.I93V	WNT5A_uc003dhm.2_Missense_Mutation_p.I78V|WNT5A_uc010hmw.2_Missense_Mutation_p.I78V|WNT5A_uc010hmx.2_Missense_Mutation_p.I4V	NM_003392	NP_003383	P41221	WNT5A_HUMAN	wingless-type MMTV integration site family,	93					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		CCTTCTCCGATGTACTGCATG	0.483													31	81					0	0	0	0	C	55513456	C	C	55513456	3	2	238	1	0	0	0	0	1	0	0	0	17459	1464	51	5	877	5	WNT5A	3	55513456	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	11070679	55513456	142508974	59	43352											
ATXN7	6314	broad.mit.edu	37	chr3	63898838	63898838	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtatatctcctagggacaGaattggacgaaagtttcaag	13	11	11	6	1	2	1	1	0	1	1	3	4	2	3	1	2	0	2	1	2	6	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:63898838G>A	uc003dlw.3	+	4	884	c.331G>A	c.(331-333)GAA>AAA	p.E111K	ATXN7_uc003dlv.2_Missense_Mutation_p.E111K|ATXN7_uc010hnv.2_Missense_Mutation_p.E111K	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	111					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		CCTAGGGACAGAATTGGACGA	0.572													8	25					0	0	0	0	A	63898838	A	A	63898838	3	1	238	1	0	0	0	0	1	0	0	0	1217	943	33	2	337	2	ATXN7	3	63898838	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	8385382	63898838	134123592	60	43353											
SUCLG2	8801	broad.mit.edu	37	chr3	67571002	67571002	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccattgcaggaccggtcCatcagaattgccaggtaggt	9	8	14	10	1	1	1	1	0	0	1	2	2	2	2	4	5	2	2	4	5	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:67571002C>A	uc003dna.3	-	5	502	c.474G>T	c.(472-474)ATG>ATT	p.M158I	SUCLG2_uc010hob.2_Missense_Mutation_p.M39I	NM_003848	NP_003839	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming beta subunit	158	ATP-grasp.				succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|skin(1)	2		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	AGGACCGGTCCATCAGAATTG	0.512													15	80					1.01871e-10	1.39512e-10	1	0	A	67571002	A	A	67571002	3	1	238	1	0	0	0	0	1	0	0	0	15431	594	21	4	996	4	SUCLG2	3	67571002	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3672164	67571002	130451428	61	43354											
EPHA3	2042	broad.mit.edu	37	chr3	89480488	89480488	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgtcctggaggatgacccAgaagctgcttatacaacaag	12	8	11	10	1	0	2	0	1	0	1	1	4	1	4	2	2	4	2	2	2	5	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:89480488A>T	uc003dqy.2	+	13	2550	c.2325A>T	c.(2323-2325)CCA>CCT	p.P775P	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	775	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		AGGATGACCCAGAAGCTGCTT	0.393										TSP Lung(6;0.00050)			7	37					0	0	0	0	T	89480488	T	T	89480488	2	4	238	1	0	0	0	0	0	0	0	1	5192	175	7	5		5	EPHA3	3	89480488	Silent	SNP	A	TCGA-CV-7248-01A-11D-2012-08	21909486	89480488	108541942	62	43355											
DPPA2	151871	broad.mit.edu	37	chr3	109031461	109031461	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aacgcttggttccatttgttCcatatttgcgtcatctttaa	8	18	6	9	2	2	0	1	0	1	0	4	0	4	0	2	1	2	3	2	1	3	8			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:109031461C>T	uc003dxo.2	-	3	359	c.112G>A	c.(112-114)GAA>AAA	p.E38K		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	38						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						TCCATTTGTTCCATATTTGCG	0.418													23	83					0	0	0	0	T	109031461	T	T	109031461	3	4	238	1	0	0	0	0	1	0	0	0	4756	864	30	2	808	2	DPPA2	3	109031461	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	19550973	109031461	88990969	63	43356											
DPPA2	151871	broad.mit.edu	37	chr3	109031510	109031510	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtcaaaatcacactttcCtcatcatctacttccccctc	10	13	2	16	0	5	0	4	0	1	0	8	0	7	0	3	0	1	0	3	0	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:109031510C>T	uc003dxo.2	-	3	310	c.63G>A	c.(61-63)GAG>GAA	p.E21E		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	21						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						TCACACTTTCCTCATCATCTA	0.408													15	79					0	0	0	0	T	109031510	T	T	109031510	2	4	238	1	0	0	0	0	0	0	0	1	4756	680	24	4		4	DPPA2	3	109031510	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	49	109031510	88990920	64	43357											
FBXO40	51725	broad.mit.edu	37	chr3	121345686	121345686	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttttgactagcatgtgtcagCcccgtgagcaggcccgagag	8	9	13	11	2	1	3	1	2	0	1	1	4	1	3	3	1	3	2	3	1	1	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:121345686C>A	uc003eeg.2	+	4	2269	c.2059C>A	c.(2059-2061)CCC>ACC	p.P687T		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	687					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding	p.P687A(1)		ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		CATGTGTCAGCCCCGTGAGCA	0.483													25	91					3.08376e-08	3.95505e-08	1	0	A	121345686	A	A	121345686	3	1	238	1	0	0	0	0	1	0	0	0	5781	739	26	4	2069	4	FBXO40	3	121345686	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	12314176	121345686	76676744	65	43358											
IGSF10	285313	broad.mit.edu	37	chr3	151163676	151163676	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgtagtgaagccagaacTctggtctggagagatgtttg	9	11	16	5	0	2	3	0	1	2	2	2	5	2	4	1	3	2	2	1	3	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:151163676T>A	uc011bod.1	-	4	4093	c.4093A>T	c.(4093-4095)AGT>TGT	p.S1365C		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1365					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGCCAGAACTCTGGTCTGGA	0.473													51	303					0	0	0	0	A	151163676	A	A	151163676	3	1	238	1	0	0	0	0	1	0	0	0	7636	1551	54	5	3838	5	IGSF10	3	151163676	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	29817990	151163676	46858754	66	43359											
PLCH1	23007	broad.mit.edu	37	chr3	155200696	155200696	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctcctgtgactgacatgTgggcagtagatacaatggtg	9	12	13	7	0	1	3	0	2	1	1	2	3	1	3	1	2	1	3	1	2	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:155200696T>G	uc011bok.1	-	23	3420	c.3143A>C	c.(3142-3144)CAC>CCC	p.H1048P	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.H1010P	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1048					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GACTGACATGTGGGCAGTAGA	0.488													24	90					0	0	0	0	G	155200696	G	G	155200696	3	3	238	1	0	0	0	0	1	0	0	0	12092	1696	59	5	1942	5	PLCH1	3	155200696	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	4037020	155200696	42821734	67	43360											
SCHIP1	29970	broad.mit.edu	37	chr3	159606694	159606694	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agacatgactattgggcagcTacaagtgatagtcaatgatc	14	10	10	7	0	1	4	1	3	0	1	2	4	1	4	0	1	2	2	0	1	5	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:159606694T>A	uc003fcs.1	+	6	1346	c.1280T>A	c.(1279-1281)CTA>CAA	p.L427Q	SCHIP1_uc003fcq.1_Missense_Mutation_p.L503Q|SCHIP1_uc003fcr.1_Missense_Mutation_p.L416Q|SCHIP1_uc003fct.1_Missense_Mutation_p.L414Q|SCHIP1_uc010hvz.1_Missense_Mutation_p.L387Q|SCHIP1_uc003fcu.1_Missense_Mutation_p.L184Q|SCHIP1_uc003fcv.1_Missense_Mutation_p.L200Q	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	427	Potential.					cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			ATTGGGCAGCTACAAGTGATA	0.383													6	54					0	0	0	0	A	159606694	A	A	159606694	3	1	238	1	0	0	0	0	1	0	0	0	13969	1522	53	5	1302	5	SCHIP1	3	159606694	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	4405998	159606694	38415736	68	43361											
ECT2	1894	broad.mit.edu	37	chr3	172480522	172480522	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatgaaagatgcactcacCttgtagttgaagagaatata	16	10	10	5	0	1	5	1	2	0	3	1	7	1	5	1	0	1	3	1	0	6	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr3:172480522C>T	uc003fii.2	+	9	976	c.838C>T	c.(838-840)CTT>TTT	p.L280F	ECT2_uc010hwv.1_Missense_Mutation_p.L311F|ECT2_uc003fih.2_Missense_Mutation_p.L279F|ECT2_uc003fij.1_Missense_Mutation_p.L280F|ECT2_uc003fik.1_Missense_Mutation_p.L280F|ECT2_uc003fil.1_Missense_Mutation_p.L311F	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	280	BRCT 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			ATGCACTCACCTTGTAGTTGA	0.348													10	37					0	0	0	0	T	172480522	T	T	172480522	3	4	238	1	0	0	0	0	1	0	0	0	4923	681	24	4	868	4	ECT2	3	172480522	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	12873828	172480522	25541908	69	43362											
GABRB1	2560	broad.mit.edu	37	chr4	47163453	47163453	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaaatcgaatgattcgacTgcatcctgatggaacagttc	14	10	9	8	2	0	2	0	2	0	0	4	6	1	3	1	1	2	2	1	1	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr4:47163453T>C	uc003gxh.2	+	4	802	c.428T>C	c.(427-429)CTG>CCG	p.L143P	GABRB1_uc011bze.1_Missense_Mutation_p.L73P	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	143	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATGATTCGACTGCATCCTGAT	0.388													18	92					0	0	0	0	C	47163453	C	C	47163453	3	2	238	1	0	0	0	0	1	0	0	0	6200	1580	55	5	442	5	GABRB1	4	47163453	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08		47163453	143990823	70	43363											
STAP1	26228	broad.mit.edu	37	chr4	68424379	68424380	+	5'Flank	DEL	TG	-	-																															tgtgtgtgtgtgtgtgcgtcTgtgtgtgtgtgtgtcctgtt																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr4:68424379_68424380delTG	uc003hde.3	+						STAP1_uc003hdf.2_5'Flank	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1						cellular membrane fusion|intracellular protein transport	cytoplasm					0						tgtgtgcgtctgtgtgtgtgtg	0.327													---	---	---								-	68424380	-	-	68424379	6	5	238	0	1	1	0	1	0	0	0	0	15318	1595	55	0		0	STAP1	4	68424379	5'Flank	DEL	TG	TCGA-CV-7248-01A-11D-2012-08	21260926	68424379	122729897	71	43364											
C4orf7	260436	broad.mit.edu	37	chr4	71096932	71096932	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaagaaagttctcctcctGatcacagccatcttggcagt	11	11	8	11	0	3	3	1	2	2	1	5	3	4	3	3	1	1	2	3	1	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr4:71096932G>A	uc003hfd.2	+	2	106	c.21G>A	c.(19-21)CTG>CTA	p.L7L		NM_152997	NP_694542	Q8NFU4	FDSCP_HUMAN	chromosome 4 open reading frame 7 precursor	7						extracellular region				central_nervous_system(1)	1						TTCTCCTCCTGATCACAGCCA	0.303													14	87					0	0	0	0	A	71096932	A	A	71096932	2	1	238	1	0	0	0	0	0	0	0	1	2289	1277	45	2		2	C4orf7	4	71096932	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	2672553	71096932	120057344	72	43365											
NKX6-1	4825	broad.mit.edu	37	chr4	85414622	85414622	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttgaggcgctctgtctcCgagtcctgcttcttcttggc	2	14	10	15	2	4	1	0	1	4	0	6	2	5	1	3	2	1	2	3	2	0	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr4:85414622C>G	uc003hpa.1	-	3	930	c.924G>C	c.(922-924)TCG>TCC	p.S308S		NM_006168	NP_006159	P78426	NKX61_HUMAN	NK6 transcription factor related, locus 1	308	Involved in DNA-binding (By similarity).				detection of glucose|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|type B pancreatic cell maturation	nucleus					0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.0013)		GCTCTGTCTCCGAGTCCTGCT	0.597													40	67					0	0	0	0	G	85414622	G	G	85414622	2	3	238	1	0	0	0	0	0	0	0	1	10511	639	23	3		3	NKX6-1	4	85414622	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	14317690	85414622	105739654	73	43366											
ALPK1	80216	broad.mit.edu	37	chr4	113356374	113356374	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaaactattgtctatttgggGgactacttgactgtgaagaa	12	13	11	5	0	1	3	0	2	1	1	1	5	1	4	0	2	2	0	0	2	6	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr4:113356374G>T	uc003iap.3	+	12	3384	c.3105G>T	c.(3103-3105)GGG>GGT	p.G1035G	ALPK1_uc003ian.3_Silent_p.G1035G|ALPK1_uc011cfx.1_Silent_p.G957G|ALPK1_uc003iao.3_RNA|ALPK1_uc010imo.2_Silent_p.G863G	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1035	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TCTATTTGGGGGACTACTTGA	0.348													42	127					6.33695e-27	9.84664e-27	1	0	T	113356374	T	T	113356374	2	4	238	1	0	0	0	0	0	0	0	1	544	1219	43	4		4	ALPK1	4	113356374	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	27941752	113356374	77797902	74	43367											
ANK2	287	broad.mit.edu	37	chr4	114163318	114163318	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaagaggaaatacaaacatgGtgaagctcttactggatcga	17	8	10	6	1	1	2	0	1	1	1	2	5	1	4	0	3	4	1	0	3	6	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr4:114163318G>C	uc003ibe.3	+	9	944	c.844G>C	c.(844-846)GTG>CTG	p.V282L	ANK2_uc003ibd.3_Missense_Mutation_p.V261L|ANK2_uc003ibf.3_Missense_Mutation_p.V282L|ANK2_uc003ibc.2_Missense_Mutation_p.V258L|ANK2_uc011cgb.1_Missense_Mutation_p.V297L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	282	ANK 8.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TACAAACATGGTGAAGCTCTT	0.438													13	32					0	0	0	0	C	114163318	C	C	114163318	3	2	238	1	0	0	0	0	1	0	0	0	621	1261	44	4	903	4	ANK2	4	114163318	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	806944	114163318	76990958	75	43368											
DCHS2	54798	broad.mit.edu	37	chr4	155249332	155249332	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccaacatatttactggttGaccttccagaacctgccatt	12	12	5	12	0	0	2	0	1	0	1	1	2	1	2	5	1	5	1	5	1	5	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr4:155249332G>A	uc003inw.2	-	12	2566	c.2566C>T	c.(2566-2568)CAA>TAA	p.Q856*	DCHS2_uc003inx.2_Nonsense_Mutation_p.Q1311*	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	856	Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTTACTGGTTGACCTTCCAGA	0.333													20	37					0	0	0	0	A	155249332	A	A	155249332	4	1	238	1	0	0	0	0	0	1	0	0	4305	1299	45	2	6336	2	DCHS2	4	155249332	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	41086014	155249332	35904944	76	43369											
TLL1	7092	broad.mit.edu	37	chr4	166916211	166916211	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taacatcacacattttttctAggcagccagagagccatgtt	12	12	7	10	0	2	1	1	0	1	1	2	2	2	1	2	1	3	2	2	1	2	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr4:166916211A>G	uc003irh.1	+	5	1162	c.515_splice	c.e5-2	p.G172_splice	TLL1_uc011cjn.1_Splice_Site_p.G172_splice|TLL1_uc011cjo.1_Splice_Site	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor						cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CATTTTTTCTAGGCAGCCAGA	0.458													26	63					0	0	0	0	G	166916211	G	G	166916211	5	3	238	1	0	0	0	0	0	0	1	0	16011	434	15	5	531	5	TLL1	4	166916211	Splice_Site	SNP	A	TCGA-CV-7248-01A-11D-2012-08	11666879	166916211	24238065	77	43370											
CDH10	1008	broad.mit.edu	37	chr5	24511436	24511436	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttatatggatgctgtgcacCtttttcacagtgatgatgcc	8	16	9	8	0	1	2	1	2	0	0	1	3	1	3	2	1	3	2	2	1	2	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:24511436C>A	uc003jgr.1	-	6	1334	c.1002G>T	c.(1000-1002)AAG>AAT	p.K334N	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	334	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TGCTGTGCACCTTTTTCACAG	0.403										HNSCC(23;0.051)			21	78					5.26018e-13	7.43046e-13	1	0	A	24511436	A	A	24511436	3	1	238	1	0	0	0	0	1	0	0	0	3111	695	24	4	1392	4	CDH10	5	24511436	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08		24511436	156403824	78	43371											
LIFR	3977	broad.mit.edu	37	chr5	38486030	38486030	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttgaagatcagcaattctCagtgtcttctgggatatgtc	9	14	9	9	0	4	2	2	1	3	1	6	3	4	3	1	1	1	1	1	1	3	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:38486030C>T	uc010ive.1	-	17	2720	c.2388G>A	c.(2386-2388)CTG>CTA	p.L796L	LIFR_uc003jli.2_Silent_p.L796L	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	796	Fibronectin type-III 6.|Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					CAGCAATTCTCAGTGTCTTCT	0.398			T	PLAG1	salivary adenoma								9	44					0	0	0	0	T	38486030	T	T	38486030	2	4	238	1	0	0	0	0	0	0	0	1	8821	813	29	2		2	LIFR	5	38486030	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	13974594	38486030	142429230	79	43372											
HEATR7B2	133558	broad.mit.edu	37	chr5	41061778	41061778	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctggggtagggaaaatctCtccagtggttgacatatttg	9	13	13	6	0	2	1	0	1	2	0	4	2	3	2	1	4	0	2	1	4	4	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:41061778C>A	uc003jmj.3	-	6	999	c.509G>T	c.(508-510)AGA>ATA	p.R170I		NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	170							binding			ovary(6)|central_nervous_system(2)	8						GGGAAAATCTCTCCAGTGGTT	0.458													22	79					4.35082e-09	5.80109e-09	1	0	A	41061778	A	A	41061778	3	1	238	1	0	0	0	0	1	0	0	0	7074	913	32	2	4396	2	HEATR7B2	5	41061778	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	2575748	41061778	139853482	80	43373											
MCTP1	79772	broad.mit.edu	37	chr5	94259701	94259701	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acttcacagagaaataagatCcaaccacttcattttctgaa	16	11	4	10	0	3	3	2	1	1	2	4	4	4	3	2	0	1	0	2	0	4	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:94259701C>T	uc003kkx.2	-	7	1238	c.1238G>A	c.(1237-1239)GGA>GAA	p.G413E	MCTP1_uc003kkv.2_Missense_Mutation_p.G192E|MCTP1_uc003kkw.2_Intron|MCTP1_uc003kkz.2_Missense_Mutation_p.G74E|MCTP1_uc003kku.2_Intron	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	413					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		GAAATAAGATCCAACCACTTC	0.269													3	25					0	0	0	0	T	94259701	T	T	94259701	3	4	238	1	0	0	0	0	1	0	0	0	9453	855	30	2	1829	2	MCTP1	5	94259701	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	53197923	94259701	86655559	81	43374											
APC	324	broad.mit.edu	37	chr5	112175846	112175846	+	Frame_Shift_Del	DEL	G	-	-																															atgagccatttatacagaaaGatgtggaattaagaataatg																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:112175846delG	uc010jby.2	+	16	4935	c.4555delG	c.(4555-4557)GATfs	p.D1519fs	APC_uc011cvt.1_Frame_Shift_Del_p.D1501fs|APC_uc003kpz.3_Frame_Shift_Del_p.D1519fs|APC_uc003kpy.3_Frame_Shift_Del_p.D1519fs|APC_uc010jbz.2_Frame_Shift_Del_p.D1236fs|APC_uc010jca.2_Frame_Shift_Del_p.D819fs	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1519	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1454fs*3(1)|p.D1519fs*2(1)|p.K1192fs*3(1)|p.?(1)|p.D1519fs*4(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TATACAGAAAGATGTGGAATT	0.388		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			---	---	---								-	112175846	-	-	112175846	7	5	238	1	0	1	0	1	0	0	0	0	763	942	33	0	4613	0	APC	5	112175846	Frame_Shift_Del	DEL	G	TCGA-CV-7248-01A-11D-2012-08	17916145	112175846	68739414	82	43375											
ADAMTS19	171019	broad.mit.edu	37	chr5	128958005	128958005	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatgaacaatgccagatcctTtttgggccattggcttcttt	8	15	9	9	0	1	2	0	1	1	1	2	3	2	2	3	2	2	1	3	2	2	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:128958005T>C	uc003kvb.1	+	10	1716	c.1716T>C	c.(1714-1716)CTT>CTC	p.L572L	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	572	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GCCAGATCCTTTTTGGGCCAT	0.448													7	25					0	0	0	0	C	128958005	C	C	128958005	2	2	238	1	0	0	0	0	0	0	0	1	264	1828	64	5		5	ADAMTS19	5	128958005	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	16782159	128958005	51957255	83	43376											
ADAMTS19	171019	broad.mit.edu	37	chr5	129070697	129070697	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataagatcacaggaagacatGgaaatgaatgtttttcctca	16	11	8	6	0	2	3	2	1	0	2	3	5	3	5	1	2	0	1	1	2	4	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:129070697G>T	uc003kvb.1	+	22	3367	c.3367G>T	c.(3367-3369)GGA>TGA	p.G1123*	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1123	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AGGAAGACATGGAAATGAATG	0.408													23	46					1.55469e-16	2.30072e-16	1	0	T	129070697	T	T	129070697	4	4	238	1	0	0	0	0	0	1	0	0	264	1349	47	4	3453	4	ADAMTS19	5	129070697	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	112692	129070697	51844563	84	43377											
PCDHA13	56136	broad.mit.edu	37	chr5	140262292	140262292	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taatcattgcagaatctagaCctccggaaactcgatttcca	13	11	6	11	2	2	2	1	0	1	2	5	4	4	3	3	1	2	1	3	1	4	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:140262292C>A	uc003lif.2	+	1	439	c.439C>A	c.(439-441)CCT>ACT	p.P147T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.P147T|PCDHA13_uc003lid.2_Missense_Mutation_p.P147T	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	147	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAATCTAGACCTCCGGAAAC	0.463													25	74					2.21704e-12	3.0674e-12	1	0	A	140262292	A	A	140262292	3	1	238	1	0	0	0	0	1	0	0	0	11577	507	18	4	441	4	PCDHA13	5	140262292	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	11191595	140262292	40652968	85	43378											
PCDHAC2	56134	broad.mit.edu	37	chr5	140346697	140346697	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgctgtgtgagcagcggcctCgctgcctgctcagcttggaa	5	9	14	13	3	1	1	1	1	0	0	2	2	1	2	2	2	5	5	2	2	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:140346697C>G	uc003lii.2	+	1	586	c.346C>G	c.(346-348)CGC>GGC	p.R116G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.R116G	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	116	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCGGCCTCGCTGCCTGCT	0.637													13	37					0	0	0	0	G	140346697	G	G	140346697	3	3	238	1	0	0	0	0	1	0	0	0	11587	884	31	3	348	3	PCDHAC2	5	140346697	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	84405	140346697	40568563	86	43379											
PCDHGA1	56114	broad.mit.edu	37	chr5	140712526	140712526	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctattcccacgaggtctccCtcactgcggactcgcggaag	7	8	10	16	4	2	0	1	0	1	0	5	3	3	2	3	3	1	0	3	3	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:140712526C>A	uc003lji.1	+	1	2275	c.2275C>A	c.(2275-2277)CTC>ATC	p.L759I	PCDHGA1_uc011dan.1_Missense_Mutation_p.L759I	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	759	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAGGTCTCCCTCACTGCGGA	0.592													38	137					1.32136e-16	1.9626e-16	1	0	A	140712526	A	A	140712526	3	1	238	1	0	0	0	0	1	0	0	0	11604	681	24	4	2277	4	PCDHGA1	5	140712526	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	365829	140712526	40202734	87	43380											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720341	140720341	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacagagactcgggccagaaCgcctggctgtcttaccacct	9	7	11	14	2	1	2	0	0	1	2	2	4	1	2	4	2	2	1	4	2	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:140720341C>T	uc003ljk.1	+	1	1988	c.1803C>T	c.(1801-1803)AAC>AAT	p.N601N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.N601N	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	601	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGCCAGAACGCCTGGCTGT	0.692													26	113					0	0	0	0	T	140720341	T	T	140720341	2	4	238	1	0	0	0	0	0	0	0	1	11608	535	19	1		1	PCDHGA2	5	140720341	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	7815	140720341	40194919	88	43381											
TCERG1	10915	broad.mit.edu	37	chr5	145838779	145838779	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcaagcacaagcagttggAgcttccacccctacgaccag	11	6	10	14	1	0	0	0	0	0	0	1	2	1	1	4	1	5	5	4	1	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr5:145838779A>G	uc003lob.2	+	4	811	c.771A>G	c.(769-771)GGA>GGG	p.G257G	TCERG1_uc003loc.2_Silent_p.G257G|TCERG1_uc011dbt.1_Silent_p.G257G	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	257	Ala/Gln-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGCAGTTGGAGCTTCCACCC	0.318													3	115					0	0	0	0	G	145838779	G	G	145838779	2	3	238	1	0	0	0	0	0	0	0	1	15751	291	11	5		5	TCERG1	5	145838779	Silent	SNP	A	TCGA-CV-7248-01A-11D-2012-08	5118438	145838779	35076481	89	43382											
DUSP22	56940	broad.mit.edu	37	chr6	348139	348139	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggagcgtgacactggtgatCgcatacatcatgaccgtcac	11	8	11	11	3	2	3	2	3	0	0	3	4	2	4	1	2	2	1	1	2	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:348139C>T	uc003msx.2	+	6	739	c.300C>T	c.(298-300)ATC>ATT	p.I100I	DUSP22_uc011dhn.1_Silent_p.I100I|DUSP22_uc003msy.1_Silent_p.I57I	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	100	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CACTGGTGATCGCATACATCA	0.607													6	238					0	0	0	0	T	348139	T	T	348139	2	4	238	1	0	0	0	0	0	0	0	1	4843	874	31	1		1	DUSP22	6	348139	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08		348139	170766928	90	43383											
HIST1H2BD	3017	broad.mit.edu	37	chr6	26158752	26158752	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcggagggcaccaaggccGtcaccaagtacaccagttcc	10	6	11	14	2	1	0	1	0	0	0	3	1	2	1	5	3	1	3	5	3	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:26158752G>T	uc003ngr.2	+	1	404	c.355G>T	c.(355-357)GTC>TTC	p.V119F	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.V119F	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	119					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						CACCAAGGCCGTCACCAAGTA	0.552													23	68					2.21704e-12	3.0674e-12	1	0	T	26158752	T	T	26158752	3	4	238	1	0	0	0	0	1	0	0	0	7182	1145	40	3	357	3	HIST1H2BD	6	26158752	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	25810613	26158752	144956315	91	43384											
OR2W1	26692	broad.mit.edu	37	chr6	29012922	29012922	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagccaagcagaataaaacCatgtaaagaactataattgc	20	7	7	7	0	0	2	0	0	0	2	0	3	0	2	2	0	5	2	2	0	10	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:29012922C>T	uc003nlw.2	-	1	31	c.31G>A	c.(31-33)GGT>AGT	p.G11S		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						AGAATAAAACCATGTAAAGAA	0.318													15	41					0	0	0	0	T	29012922	T	T	29012922	3	4	238	1	0	0	0	0	1	0	0	0	11086	594	21	4	935	4	OR2W1	6	29012922	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	2854170	29012922	142102145	92	43385											
MCCD1	401250	broad.mit.edu	37	chr6	31495806	31495811	+	5'Flank	DEL	AAAAAA	-	-																															acagagcgagactccgtctcAaaaaaaaaaaaaaaaaaaaa																								rs147277013		TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:31495806_31495811delAAAAAA	uc003ntp.1	+							NM_001011700	NP_001011700	P59942	MCCD1_HUMAN	mitochondrial coiled-coil domain 1 precursor							mitochondrion					0						actccgtctcaaaaaaaaaaaaaaaa	0.204													---	---	---								-	31495811	-	-	31495806	6	5	238	0	1	1	0	1	0	0	0	0	9429	145	5	0		0	MCCD1	6	31495806	5'Flank	DEL	AAAAAA	TCGA-CV-7248-01A-11D-2012-08	2482884	31495806	139619261	93	43386											
KCNK5	8645	broad.mit.edu	37	chr6	39159385	39159385	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggactccttccgtcgccGccgccgcttcttaatggctt	6	11	9	15	5	1	0	0	0	1	0	4	1	3	1	5	2	0	2	5	2	2	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr6:39159385G>A	uc003oon.2	-	5	1145	c.781C>T	c.(781-783)CGG>TGG	p.R261W		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	261	Cytoplasmic (Potential).				excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						TTCCGTCGCCGCCGCCGCTTC	0.572													10	99					0	0	0	0	A	39159385	A	A	39159385	3	1	238	1	0	0	0	0	1	0	0	0	8108	1086	38	1	722	1	KCNK5	6	39159385	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	7663579	39159385	131955682	94	43387											
C6orf138	442213	broad.mit.edu	37	chr6	48036085	48036085	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggggtgtgtaagtccgAatagagctggcttttggact	8	11	14	8	1	0	1	0	0	0	1	1	3	1	2	2	4	1	3	2	4	3	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:48036085A>T	uc011dwm.1	-	1	341	c.256T>A	c.(256-258)TCG>ACG	p.S86T	C6orf138_uc011dwn.1_Intron|C6orf138_uc003ozf.2_Missense_Mutation_p.S103T	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	103						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						TGTAAGTCCGAATAGAGCTGG	0.627													22	87					0	0	0	0	T	48036085	T	T	48036085	3	4	238	1	0	0	0	0	1	0	0	0	2342	246	9	5	2245	5	C6orf138	6	48036085	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	8876700	48036085	123078982	95	43388											
KHDRBS2	202559	broad.mit.edu	37	chr6	62604606	62604606	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctggcactgttggtgccccCcgggctcgaggggtagggac	4	7	17	13	2	0	0	0	0	0	0	1	2	0	1	4	6	1	4	4	6	1	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:62604606C>A	uc003peg.2	-	6	991	c.744G>T	c.(742-744)CGG>CGT	p.R248R		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	248	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TTGGTGCCCCCCGGGCTCGAG	0.552													17	47					1.99824e-07	2.49934e-07	1	0	A	62604606	A	A	62604606	2	1	238	1	0	0	0	0	0	0	0	1	8186	610	22	4		4	KHDRBS2	6	62604606	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	14568521	62604606	108510461	96	43389											
KHDRBS2	202559	broad.mit.edu	37	chr6	62887094	62887094	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtatatatggtagtacctttGgatactgcttgacaggaatc	11	14	10	6	0	0	1	0	1	0	0	1	3	0	3	1	3	3	4	1	3	7	8			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:62887094G>T	uc003peg.2	-	2	462	c.215C>A	c.(214-216)CCA>CAA	p.P72Q		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	72	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TAGTACCTTTGGATACTGCTT	0.279													5	26					0.00116845	0.00128625	1	0	T	62887094	T	T	62887094	3	4	238	1	0	0	0	0	1	0	0	0	8186	1348	47	4	866	4	KHDRBS2	6	62887094	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	282488	62887094	108227973	97	43390											
EYS	346007	broad.mit.edu	37	chr6	66044934	66044934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acactcattttcttgatcatCagttgtattttccagataca	11	17	4	9	0	4	2	3	1	1	1	5	2	5	2	1	0	1	2	1	0	2	8			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:66044934C>T	uc011dxu.1	-	11	2243	c.1705G>A	c.(1705-1707)GAT>AAT	p.D569N	EYS_uc003peq.2_Missense_Mutation_p.D569N|EYS_uc003per.1_Missense_Mutation_p.D569N	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	569	EGF-like 6.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TCTTGATCATCAGTTGTATTT	0.353													5	58					0	0	0	0	T	66044934	T	T	66044934	3	4	238	1	0	0	0	0	1	0	0	0	5357	826	29	2	7823	2	EYS	6	66044934	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3157840	66044934	105070133	98	43391											
EYS	346007	broad.mit.edu	37	chr6	66094281	66094281	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtattaaattacttacttTgaatcttccaattatattga	14	19	3	5	0	1	2	0	2	1	0	2	2	2	2	1	0	2	1	1	0	9	9			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:66094281T>C	uc011dxu.1	-	8	1835	c.1297A>G	c.(1297-1299)AAA>GAA	p.K433E	EYS_uc003peq.2_Missense_Mutation_p.K433E|EYS_uc003per.1_Missense_Mutation_p.K433E	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	433					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TTACTTACTTTGAATCTTCCA	0.318													8	32					0	0	0	0	C	66094281	C	C	66094281	3	2	238	1	0	0	0	0	1	0	0	0	5357	1821	63	5	8243	5	EYS	6	66094281	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	49347	66094281	105020786	99	43392											
BAI3	577	broad.mit.edu	37	chr6	69349246	69349246	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacccctgaatgagcagacaGagggctgcctgacccaggag	11	5	13	12	0	0	5	0	3	0	2	0	6	0	6	4	2	3	2	4	2	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:69349246G>T	uc003pev.3	+	3	1127	c.679G>T	c.(679-681)GAG>TAG	p.E227*	BAI3_uc010kak.2_Nonsense_Mutation_p.E227*	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	227	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TGAGCAGACAGAGGGCTGCCT	0.532													6	36					0.00116845	0.00128625	1	0	T	69349246	T	T	69349246	4	4	238	1	0	0	0	0	0	1	0	0	1302	943	33	2	681	2	BAI3	6	69349246	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3254965	69349246	101765821	100	43393											
BAI3	577	broad.mit.edu	37	chr6	69684742	69684742	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttggcattcaatcaatgtcCcctgaatgccacaggtacag	11	10	8	12	0	2	1	2	1	0	0	3	1	3	1	3	2	2	2	3	2	4	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:69684742C>T	uc003pev.3	+	9	2061	c.1613C>T	c.(1612-1614)CCC>CTC	p.P538L	BAI3_uc010kak.2_Missense_Mutation_p.P538L	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	538	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AATCAATGTCCCCTGAATGCC	0.443													13	33					0	0	0	0	T	69684742	T	T	69684742	3	4	238	1	0	0	0	0	1	0	0	0	1302	623	22	4	1639	4	BAI3	6	69684742	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	335496	69684742	101430325	101	43394											
FRK	2444	broad.mit.edu	37	chr6	116288845	116288845	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctatctcccattggtccacgGttttatacgacaaatcaaat	12	13	5	11	2	2	0	1	0	1	0	4	1	3	0	2	2	1	1	2	2	5	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:116288845G>A	uc003pwi.1	-	4	1115	c.668C>T	c.(667-669)ACC>ATC	p.T223I		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	223					negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TTGGTCCACGGTTTTATACGA	0.388													13	53					0	0	0	0	A	116288845	A	A	116288845	3	1	238	1	0	0	0	0	1	0	0	0	6082	1261	44	4	869	4	FRK	6	116288845	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	46604103	116288845	54826222	102	43395											
LAMA2	3908	broad.mit.edu	37	chr6	129762020	129762020	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacaagccaacgacacagctAaagatgtactggcacagatt	16	6	9	10	1	0	2	0	0	0	2	0	4	0	2	1	1	4	3	1	1	5	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:129762020A>G	uc003qbn.2	+	43	6250	c.6145A>G	c.(6145-6147)AAA>GAA	p.K2049E	LAMA2_uc003qbo.2_Missense_Mutation_p.K2049E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2049	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CGACACAGCTAAAGATGTACT	0.453													7	47					0	0	0	0	G	129762020	G	G	129762020	3	3	238	1	0	0	0	0	1	0	0	0	8646	363	13	5	6315	5	LAMA2	6	129762020	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	13473175	129762020	41353047	103	43396											
ENPP1	5167	broad.mit.edu	37	chr6	132206176	132206176	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgactttgattatgatggacGttgtgattccttagagaatc	10	16	10	5	1	0	5	0	4	0	1	2	7	1	6	1	1	0	1	1	1	3	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:132206176G>C	uc011ecf.1	+	23	2437	c.2417G>C	c.(2416-2418)CGT>CCT	p.R806P		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	806	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TATGATGGACGTTGTGATTCC	0.398													8	38					0	0	0	0	C	132206176	C	C	132206176	3	2	238	1	0	0	0	0	1	0	0	0	5153	1145	40	3	2507	3	ENPP1	6	132206176	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	2444156	132206176	38908891	104	43397											
UTRN	7402	broad.mit.edu	37	chr6	145157526	145157526	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccagagtcgattatatctcCccatcacacgtctgaggatt	10	11	8	12	2	3	2	1	1	2	1	5	4	3	3	3	1	0	0	3	1	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:145157526C>G	uc003qkt.2	+	70	10006	c.9914C>G	c.(9913-9915)CCC>CGC	p.P3305R		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	3305					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATTATATCTCCCCATCACACG	0.502													29	125					0	0	0	0	G	145157526	G	G	145157526	3	3	238	1	0	0	0	0	1	0	0	0	17171	623	22	4	10192	4	UTRN	6	145157526	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	12951350	145157526	25957541	105	43398											
SYNE1	23345	broad.mit.edu	37	chr6	152655143	152655143	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgggagaatttctgttacCtggccaagttatcccattct	9	14	8	10	0	2	1	0	0	2	1	3	2	3	1	3	2	1	2	3	2	4	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:152655143C>G	uc010kiw.2	-	77	13396	c.12794G>C	c.(12793-12795)AGA>ACA	p.R4265T	SYNE1_uc003qot.3_Missense_Mutation_p.R4194T|SYNE1_uc003qou.3_Missense_Mutation_p.R4265T|SYNE1_uc010kiz.2_Missense_Mutation_p.R20T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4265	Cytoplasmic (Potential).|Spectrin 12.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTCTGTTACCTGGCCAAGTT	0.318										HNSCC(10;0.0054)			16	82					0	0	0	0	G	152655143	G	G	152655143	3	3	238	1	0	0	0	0	1	0	0	0	15511	695	24	4	13952	4	SYNE1	6	152655143	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	7497617	152655143	18459924	106	43399											
SYNE1	23345	broad.mit.edu	37	chr6	152674536	152674536	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattctgattcctccaaactCtgaatctcctcctccaggaa	10	12	5	14	0	3	2	0	2	3	0	8	4	7	3	5	1	1	0	5	1	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:152674536C>T	uc010kiw.2	-	69	11717	c.11115G>A	c.(11113-11115)CAG>CAA	p.Q3705Q	SYNE1_uc003qot.3_Silent_p.Q3690Q|SYNE1_uc003qou.3_Silent_p.Q3705Q|SYNE1_uc010kja.1_Silent_p.Q410Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3705	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTCCAAACTCTGAATCTCCT	0.388										HNSCC(10;0.0054)			9	44					0	0	0	0	T	152674536	T	T	152674536	2	4	238	1	0	0	0	0	0	0	0	1	15511	912	32	2		2	SYNE1	6	152674536	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	19393	152674536	18440531	107	43400											
UNC93A	54346	broad.mit.edu	37	chr6	167708043	167708043	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagggcctgggtgtcacagcGctcagcaccctctatggagg	7	7	15	12	1	3	0	2	0	1	0	3	2	3	1	2	4	2	2	2	4	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr6:167708043G>T	uc003qvq.2	+	2	301	c.126G>T	c.(124-126)GCG>GCT	p.A42A	UNC93A_uc003qvr.2_Silent_p.A42A	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	42	Helical; (Potential).					integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GTGTCACAGCGCTCAGCACCC	0.617													102	114					3.71036e-49	5.87838e-49	1	0	T	167708043	T	T	167708043	2	4	238	1	0	0	0	0	0	0	0	1	17064	1074	38	3		3	UNC93A	6	167708043	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	15033507	167708043	3407024	108	43401											
THSD7A	221981	broad.mit.edu	37	chr7	11514030	11514030	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtctgcatgccgacagagCaggaggcctccccattccaa	9	8	10	14	1	1	1	0	0	1	1	3	3	3	2	5	2	3	2	5	2	1	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:11514030C>A	uc003ssf.3	-	8	2435	c.2183G>T	c.(2182-2184)TGC>TTC	p.C728F		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	728	TSP type-1 7.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GCCGACAGAGCAGGAGGCCTC	0.507										HNSCC(18;0.044)			13	57					7.03913e-09	9.29349e-09	1	0	A	11514030	A	A	11514030	3	1	238	1	0	0	0	0	1	0	0	0	15945	710	25	4	2870	4	THSD7A	7	11514030	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08		11514030	147624633	109	43402											
CDCA7L	55536	broad.mit.edu	37	chr7	21942677	21942677	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggcacagcggccgtcaCgcttccgacagtagctgcaa	8	7	12	14	4	1	0	1	0	0	0	2	1	2	0	2	2	3	5	2	2	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:21942677C>A	uc010kuk.2	-	9	1373	c.1253G>T	c.(1252-1254)CGT>CTT	p.R418L	CDCA7L_uc003sve.3_Missense_Mutation_p.R384L|CDCA7L_uc010kul.2_Missense_Mutation_p.R372L|CDCA7L_uc003svf.3_Missense_Mutation_p.R417L	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	418					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						GCGGCCGTCACGCTTCCGACA	0.493													9	39					0.000442599	0.00049259	1	0	A	21942677	A	A	21942677	3	1	238	1	0	0	0	0	1	0	0	0	3106	536	19	3	119	3	CDCA7L	7	21942677	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	10428647	21942677	137195986	110	43403											
NFE2L3	9603	broad.mit.edu	37	chr7	26217588	26217588	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggtactaagagaaaagcAcgaagctgtggatcatagtt	14	9	13	5	1	1	1	1	0	0	1	1	4	1	2	0	3	3	4	0	3	6	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:26217588A>G	uc003sxq.2	+	2	868	c.596A>G	c.(595-597)CAC>CGC	p.H199R		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	199					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						AGAGAAAAGCACGAAGCTGTG	0.393													12	58					0	0	0	0	G	26217588	G	G	26217588	3	3	238	1	0	0	0	0	1	0	0	0	10423	159	6	5	602	5	NFE2L3	7	26217588	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	4274911	26217588	132921075	111	43404											
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26236079	26236079	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatttccaccgccaccacgTgaatccccaaagccaaagtt	14	7	5	15	2	0	1	0	1	0	0	2	1	2	1	7	0	1	1	7	0	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:26236079T>G	uc003sxr.3	-	7	852	c.636A>C	c.(634-636)TCA>TCC	p.S212S	HNRNPA2B1_uc003sxs.3_Silent_p.S200S	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	212	Gly-rich.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CGCCACCACGTGAATCCCCAA	0.408			T	ETV1	prostate								18	66					0	0	0	0	G	26236079	G	G	26236079	2	3	238	1	0	0	0	0	0	0	0	1	7298	1683	59	5		5	HNRNPA2B1	7	26236079	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	18491	26236079	132902584	112	43405											
AMPH	273	broad.mit.edu	37	chr7	38471788	38471788	+	Splice_Site	DEL	C	-	-																															acagagttattagtggcttaCcgtccataggtcccagggca																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:38471788delC	uc003tgu.2	-	13	1227	c.1158_splice	c.e13+1	p.T386_splice	AMPH_uc003tgv.2_Splice_Site_p.T386_splice|AMPH_uc003tgt.2_Splice_Site_p.T139_splice|AMPH_uc003tgw.1_5'Flank|AMPH_uc010kxl.1_5'Flank	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1						endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TAGTGGCTTACCGTCCATAGG	0.328													---	---	---								-	38471788	-	-	38471788	8	5	238	1	0	1	0	1	0	0	1	0	588	521	18	0	964	0	AMPH	7	38471788	Splice_Site	DEL	C	TCGA-CV-7248-01A-11D-2012-08	12235709	38471788	120666875	113	43406											
AMPH	273	broad.mit.edu	37	chr7	38530673	38530673	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgtcaggaaattgccccaGgtaggtatccagtgttagca	11	11	11	8	0	1	0	1	0	0	0	2	1	2	1	3	3	2	4	3	3	5	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:38530673G>T	uc003tgu.2	-	5	442	c.373C>A	c.(373-375)CTG>ATG	p.L125M	AMPH_uc003tgv.2_Missense_Mutation_p.L125M	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	125	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						AATTGCCCCAGGTAGGTATCC	0.413													33	155					3.76114e-14	5.38829e-14	1	0	T	38530673	T	T	38530673	3	4	238	1	0	0	0	0	1	0	0	0	588	991	35	4	1782	4	AMPH	7	38530673	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	58885	38530673	120607990	114	43407											
POM121L12	285877	broad.mit.edu	37	chr7	53103954	53103954	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taggttcgacgggccgttgtGgttcgaggtctcagacagca	7	10	15	9	4	1	1	1	0	1	1	4	3	1	1	1	4	1	4	1	4	1	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:53103954G>T	uc003tpz.2	+	1	606	c.590G>T	c.(589-591)TGG>TTG	p.W197L		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	197											0						GGGCCGTTGTGGTTCGAGGTC	0.622													15	71					0.000219431	0.000247627	1	0	T	53103954	T	T	53103954	3	4	238	1	0	0	0	0	1	0	0	0	12296	1357	47	4	592	4	POM121L12	7	53103954	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	14573281	53103954	106034709	115	43408											
PCLO	27445	broad.mit.edu	37	chr7	82585852	82585852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaagtgtctttcctttcttCttgactctctttgatctcct	6	20	4	11	0	5	2	0	2	5	0	8	2	6	2	2	0	0	0	2	0	2	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:82585852C>T	uc003uhx.2	-	5	4706	c.4417G>A	c.(4417-4419)GAA>AAA	p.E1473K	PCLO_uc003uhv.2_Missense_Mutation_p.E1473K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1404					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTCCTTTCTTCTTGACTCTCT	0.363													9	47					0	0	0	0	T	82585852	T	T	82585852	3	4	238	1	0	0	0	0	1	0	0	0	11637	922	32	2	11112	2	PCLO	7	82585852	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	29481898	82585852	76552811	116	43409											
GRM3	2913	broad.mit.edu	37	chr7	86468529	86468529	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggatgctatgaccttcctGaggactacatcaggtgggaa	10	10	12	9	0	1	2	1	2	0	0	2	5	2	5	2	4	2	1	2	4	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:86468529G>T	uc003uid.2	+	4	2798	c.1699G>T	c.(1699-1701)GAG>TAG	p.E567*	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Nonsense_Mutation_p.E439*|GRM3_uc010leh.2_Nonsense_Mutation_p.E159*	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	567	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGACCTTCCTGAGGACTACAT	0.498													15	91					7.93312e-07	9.65356e-07	1	0	T	86468529	T	T	86468529	4	4	238	1	0	0	0	0	0	1	0	0	6837	1291	45	2	1709	2	GRM3	7	86468529	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3882677	86468529	72670134	117	43410											
ABCB1	5243	broad.mit.edu	37	chr7	87135257	87135257	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgacgtggcttcatccaaaaGcaaaatatgaggctgtctaa	14	10	9	8	1	2	2	1	2	1	0	3	2	3	2	1	2	1	3	1	2	6	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:87135257G>C	uc003uiz.1	-	28	4010	c.3592C>G	c.(3592-3594)CTT>GTT	p.L1198V	ABCB1_uc011khc.1_Missense_Mutation_p.L1134V	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	1198	Cytoplasmic (Potential).|ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCATCCAAAAGCAAAATATGA	0.418													10	36					0	0	0	0	C	87135257	C	C	87135257	3	2	238	1	0	0	0	0	1	0	0	0	40	971	34	4	258	4	ABCB1	7	87135257	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	666728	87135257	72003406	118	43411											
MGC26647	219557	broad.mit.edu	37	chr7	88423800	88423800	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcgagatacataactggaaCttttatcactgaaacatgcc	14	11	7	9	1	1	2	1	1	0	1	2	4	1	3	1	1	5	0	1	1	5	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:88423800C>A	uc003ujv.2	-	2	639	c.457G>T	c.(457-459)GTT>TTT	p.V153F	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	153											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			ATAACTGGAACTTTTATCACT	0.348													12	58					6.40141e-05	7.32626e-05	1	0	A	88423800	A	A	88423800	3	1	238	1	0	0	0	0	1	0	0	0	9603	565	20	4	308	4	MGC26647	7	88423800	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1288543	88423800	70714863	119	43412											
AKAP9	10142	broad.mit.edu	37	chr7	91671405	91671405	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggtttcagagagagagaggGtgcttttagaggagctggaa	11	10	17	3	0	1	4	1	0	0	4	1	8	1	6	0	4	2	3	0	4	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:91671405G>T	uc003ulg.2	+	19	5188	c.4963G>T	c.(4963-4965)GTG>TTG	p.V1655L	AKAP9_uc003ulf.2_Missense_Mutation_p.V1655L|AKAP9_uc003uli.2_Missense_Mutation_p.V1280L	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1667					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAGAGAGAGGGTGCTTTTAGA	0.423			T	BRAF	papillary thyroid								9	37					2.74318e-10	3.71894e-10	1	0	T	91671405	T	T	91671405	3	4	238	1	0	0	0	0	1	0	0	0	459	1261	44	4	5037	4	AKAP9	7	91671405	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3247605	91671405	67467258	120	43413											
CASD1	64921	broad.mit.edu	37	chr7	94146967	94146967	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgcataaatacaaaatcAggtaacatttcttcattttg	15	15	5	6	0	3	1	2	1	1	0	3	1	3	1	0	1	3	2	0	1	6	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:94146967A>T	uc003uni.3	+	2	456	c.229A>T	c.(229-231)AGT>TGT	p.S77C	CASD1_uc003unh.2_Missense_Mutation_p.S77C|CASD1_uc003unj.3_Missense_Mutation_p.S77C	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	77						integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			ATACAAAATCAGGTAACATTT	0.378													5	44					0	0	0	0	T	94146967	T	T	94146967	3	4	238	1	0	0	0	0	1	0	0	0	2676	202	7	5	235	5	CASD1	7	94146967	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	2475562	94146967	64991696	121	43414											
GIGYF1	64599	broad.mit.edu	37	chr7	100281723	100281723	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggcggcggcggtggtggCggtgtcaggtcccccagagc	3	7	20	11	4	1	1	1	0	0	1	2	1	2	1	2	8	1	0	2	8	0	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:100281723C>G	uc003uwg.1	-	15	2797	c.1788G>C	c.(1786-1788)CCG>CCC	p.P596P		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	596	Poly-Pro.|Gln-rich.									large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GCGGTGGTGGCGGTGTCAGGT	0.687													11	41					0	0	0	0	G	100281723	G	G	100281723	2	3	238	1	0	0	0	0	0	0	0	1	6414	755	27	3		3	GIGYF1	7	100281723	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	6134756	100281723	58856940	122	43415											
CUX1	1523	broad.mit.edu	37	chr7	101813749	101813749	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagaggtggctcagagagaGgcggagaccttaagggaaca	13	4	17	7	1	1	4	1	0	0	4	1	7	1	5	1	5	1	2	1	5	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr7:101813749G>A	uc003uyx.3	+	10	785	c.747G>A	c.(745-747)GAG>GAA	p.E249E	CUX1_uc003uys.3_Silent_p.E260E|CUX1_uc003uyt.2_Silent_p.E260E|CUX1_uc011kkn.1_Silent_p.E223E|CUX1_uc003uyw.2_Silent_p.E214E|CUX1_uc003uyv.2_Silent_p.E244E|CUX1_uc003uyu.2_Silent_p.E260E	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	249	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CTCAGAGAGAGGCGGAGACCT	0.517													3	4					0	0	0	0	A	101813749	A	A	101813749	2	1	238	1	0	0	0	0	0	0	0	1	4081	991	35	4		4	CUX1	7	101813749	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1532026	101813749	57324914	123	43416											
PMPCB	9512	broad.mit.edu	37	chr7	102952105	102952105	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaggatgcgactctgtacAagtgtcacagaaagtgaggt	12	11	12	6	1	2	2	1	1	1	1	2	4	2	3	0	2	2	1	0	2	4	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:102952105A>T	uc003vbl.2	+	10	1204	c.1170A>T	c.(1168-1170)ACA>ACT	p.T390T	PMPCB_uc003vbk.1_Silent_p.T390T|PMPCB_uc003vbm.2_Silent_p.T299T|PMPCB_uc010liv.2_Silent_p.T296T|PMPCB_uc010liw.2_Intron|PMPCB_uc011kll.1_Silent_p.T285T|PMPCB_uc011klm.1_Silent_p.T265T	NM_004279	NP_004270	O75439	MPPB_HUMAN	mitochondrial processing peptidase beta subunit	390					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4						GACTCTGTACAAGTGTCACAG	0.363													5	33					0	0	0	0	T	102952105	T	T	102952105	2	4	238	1	0	0	0	0	0	0	0	1	12196	117	5	5		5	PMPCB	7	102952105	Silent	SNP	A	TCGA-CV-7248-01A-11D-2012-08	1138356	102952105	56186558	124	43417											
RELN	5649	broad.mit.edu	37	chr7	103179743	103179743	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaaatcatcttccaagaccGtattaccagaaatatttcct	14	13	4	10	1	2	3	1	1	1	2	4	3	4	3	4	0	1	1	4	0	6	5	rs116065504	by1000genomes	TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:103179743G>T	uc003vca.2	-	45	7122	c.6962C>A	c.(6961-6963)ACG>AAG	p.T2321K	RELN_uc010liz.2_Missense_Mutation_p.T2321K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2321					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.T2321T(1)		ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCCAAGACCGTATTACCAGA	0.393													7	29					0.00198382	0.00217199	1	0	T	103179743	T	T	103179743	3	4	238	1	0	0	0	0	1	0	0	0	13285	1145	40	3	3504	3	RELN	7	103179743	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	227638	103179743	55958920	125	43418											
PPP1R3A	5506	broad.mit.edu	37	chr7	113518605	113518605	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtaatgacccatgaggAttcttccacagatgttatat	11	15	7	8	0	2	3	0	2	2	1	3	4	3	4	2	1	0	2	2	1	3	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:113518605A>G	uc010ljy.1	-	4	2573	c.2542T>C	c.(2542-2544)TCC>CCC	p.S848P		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	848					glycogen metabolic process	integral to membrane		p.S848Y(1)		lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ACCCATGAGGATTCTTCCACA	0.373													3	127					0	0	0	0	G	113518605	G	G	113518605	3	3	238	1	0	0	0	0	1	0	0	0	12431	333	12	5	830	5	PPP1R3A	7	113518605	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	10338862	113518605	45620058	126	43419											
IQUB	154865	broad.mit.edu	37	chr7	123097469	123097469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttagcttgagatgagcagctGcttcatctttggtaagaaga	11	13	11	6	0	2	4	1	2	1	3	2	5	2	4	0	1	4	5	0	1	3	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:123097469G>A	uc003vkn.2	-	12	2736	c.2159C>T	c.(2158-2160)GCA>GTA	p.A720V	IQUB_uc011kny.1_Missense_Mutation_p.A53V|IQUB_uc003vko.2_Missense_Mutation_p.A720V|IQUB_uc010lkt.2_RNA	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	720										ovary(3)|large_intestine(1)	4						ATGAGCAGCTGCTTCATCTTT	0.403													8	86					0	0	0	0	A	123097469	A	A	123097469	3	1	238	1	0	0	0	0	1	0	0	0	7859	1319	46	4	224	4	IQUB	7	123097469	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	9578864	123097469	36041194	127	43420											
GRM8	2918	broad.mit.edu	37	chr7	126173059	126173059	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggatgaaagctaaccaaaTgatgcaggtggtatacatgg	14	8	14	5	0	0	2	0	2	0	0	0	3	0	3	1	5	4	3	1	5	5	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:126173059T>C	uc003vlr.2	-	8	2688	c.2377A>G	c.(2377-2379)ATT>GTT	p.I793V	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.I793V|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	793	Helical; Name=6; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GCTAACCAAATGATGCAGGTG	0.398										HNSCC(24;0.065)			6	34					0	0	0	0	C	126173059	C	C	126173059	3	2	238	1	0	0	0	0	1	0	0	0	6842	1464	51	5	411	5	GRM8	7	126173059	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	3075590	126173059	32965604	128	43421											
PAX4	5078	broad.mit.edu	37	chr7	127253104	127253104	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcatttcccacttgagcttCtcttgccgacgccatttggc	5	14	8	14	2	1	1	0	1	1	0	3	2	2	1	3	1	3	2	3	1	0	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:127253104C>T	uc010lld.1	-	6	869	c.663G>A	c.(661-663)GAG>GAA	p.E221E	PAX4_uc003vmf.2_Silent_p.E219E|PAX4_uc003vmg.1_Silent_p.E221E|PAX4_uc003vmh.2_Silent_p.E219E	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	229	Homeobox.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACTTGAGCTTCTCTTGCCGAC	0.448													13	68					0	0	0	0	T	127253104	T	T	127253104	2	4	238	1	0	0	0	0	0	0	0	1	11535	912	32	2		2	PAX4	7	127253104	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1080045	127253104	31885559	129	43422											
MGAM	8972	broad.mit.edu	37	chr7	141752606	141752607	+	Frame_Shift_Ins	INS	-	T	T																															tccaattcttctggagtcccINStttttgctattttgtcaacg																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:141752606_141752607insT	uc003vwy.2	+	26	3035_3036	c.2981_2982insT	c.(2980-2982)CCTfs	p.P994fs		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	994	Lumenal (Potential).|P-type 2.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TCTGGAGTCCCTTTTTGCTATT	0.421													---	---	---								T	141752607	T	T	141752606	7	5	238	1	0	1	1	0	0	0	0	0	9594	681	24	0	3079	0	MGAM	7	141752606	Frame_Shift_Ins	INS	-	TCGA-CV-7248-01A-11D-2012-08	14499502	141752606	17386057	130	43423											
MGAM	8972	broad.mit.edu	37	chr7	141765147	141765147	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaagcagagccgtgcaggaGgtgacgggacagcgaggggt	10	3	19	9	3	0	2	0	1	0	1	0	5	0	4	2	5	4	2	2	5	1	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:141765147G>T	uc003vwy.2	+	38	4551	c.4497G>T	c.(4495-4497)GAG>GAT	p.E1499D		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1499	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCGTGCAGGAGGTGACGGGAC	0.612													9	14					0.00010058	0.000114463	1	0	T	141765147	T	T	141765147	3	4	238	1	0	0	0	0	1	0	0	0	9594	991	35	4	4643	4	MGAM	7	141765147	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	12541	141765147	17373516	131	43424											
CNTNAP2	26047	broad.mit.edu	37	chr7	147259327	147259327	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggacctctggggcctctGaaagtttactgcaacatgac	10	9	11	11	1	2	2	0	2	2	0	2	3	2	3	2	3	4	2	2	3	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr7:147259327G>T	uc003weu.1	+	12	2391	c.1875G>T	c.(1873-1875)CTG>CTT	p.L625L		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	625	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGGGGCCTCTGAAAGTTTACT	0.408										HNSCC(39;0.1)			6	56					6.5536e-12	9.00563e-12	1	0	T	147259327	T	T	147259327	2	4	238	1	0	0	0	0	0	0	0	1	3662	1277	45	2		2	CNTNAP2	7	147259327	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	5494180	147259327	11879336	132	43425											
LONRF1	91694	broad.mit.edu	37	chr8	12583338	12583338	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagctgcaggcttgagagtaAaccaaatcatgaagctctct	13	9	9	10	0	2	2	1	2	1	1	3	3	2	2	1	1	4	5	1	1	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:12583338A>T	uc003wwd.1	-	11	2124	c.2061T>A	c.(2059-2061)GTT>GTA	p.V687V	LONRF1_uc011kxv.1_Silent_p.V276V|LONRF1_uc010lsp.1_Silent_p.V287V	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	687	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		CTTGAGAGTAAACCAAATCAT	0.413													4	33					0	0	0	0	T	12583338	T	T	12583338	2	4	238	1	0	0	0	0	0	0	0	1	8944	1	1	5		5	LONRF1	8	12583338	Silent	SNP	A	TCGA-CV-7248-01A-11D-2012-08		12583338	133780684	133	43426											
SGCZ	137868	broad.mit.edu	37	chr8	14095184	14095184	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagactgtaagaccagcggaCtatcctgggaaacatgtata	14	8	10	9	1	0	2	0	0	0	2	1	4	1	4	2	2	2	2	2	2	5	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:14095184C>A	uc003wwq.2	-	4	1001	c.341G>T	c.(340-342)AGT>ATT	p.S114I	SGCZ_uc010lss.2_Missense_Mutation_p.S67I	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	101	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GACCAGCGGACTATCCTGGGA	0.353													56	162					1.51943e-15	2.21606e-15	1	0	A	14095184	A	A	14095184	3	1	238	1	0	0	0	0	1	0	0	0	14269	565	20	4	617	4	SGCZ	8	14095184	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1511846	14095184	132268838	134	43427											
TACC1	6867	broad.mit.edu	37	chr8	38688648	38688648	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactttctgtcttaggcataGagaaggagacgtgccagaag	12	9	13	7	1	2	3	0	0	2	3	2	6	2	3	1	2	1	1	1	2	4	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:38688648G>A	uc010lwp.2	+	6	2045	c.1666G>A	c.(1666-1668)GAG>AAG	p.E556K	TACC1_uc011lby.1_Missense_Mutation_p.E361K|TACC1_uc003xma.2_5'UTR|TACC1_uc003xlz.2_Missense_Mutation_p.E361K|TACC1_uc003xmc.3_Missense_Mutation_p.E360K|TACC1_uc011lbz.1_Missense_Mutation_p.E543K|TACC1_uc003xmb.3_Missense_Mutation_p.E482K|TACC1_uc003xme.1_Missense_Mutation_p.E130K|TACC1_uc003xmd.1_Missense_Mutation_p.E118K|TACC1_uc010lwo.1_Missense_Mutation_p.E89K|TACC1_uc003xmf.3_Missense_Mutation_p.E146K|TACC1_uc011lca.1_Missense_Mutation_p.E539K|TACC1_uc011lcb.1_Missense_Mutation_p.E332K|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_Missense_Mutation_p.E373K|TACC1_uc010lwq.2_Missense_Mutation_p.E373K	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	556					cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			CTTAGGCATAGAGAAGGAGAC	0.483													9	29					0	0	0	0	A	38688648	A	A	38688648	3	1	238	1	0	0	0	0	1	0	0	0	15567	943	33	2	1688	2	TACC1	8	38688648	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	24593464	38688648	107675374	135	43428											
ANK1	286	broad.mit.edu	37	chr8	41552254	41552254	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtgacatgatcacgaagtaCagcgggaagtcggtggtgat	11	8	15	7	4	1	3	1	3	0	0	2	5	1	4	0	3	2	1	0	3	3	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:41552254C>T	uc003xok.2	-	28	3267	c.3183G>A	c.(3181-3183)CTG>CTA	p.L1061L	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Silent_p.L377L|ANK1_uc003xoi.2_Silent_p.L1061L|ANK1_uc003xoj.2_Silent_p.L1061L|ANK1_uc003xol.2_Silent_p.L1061L|ANK1_uc003xom.2_Silent_p.L1102L	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1061					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton	p.L1061V(1)		ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCACGAAGTACAGCGGGAAGT	0.607													8	31					0	0	0	0	T	41552254	T	T	41552254	2	4	238	1	0	0	0	0	0	0	0	1	620	465	17	4		4	ANK1	8	41552254	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	2863606	41552254	104811768	136	43429											
NCOA2	10499	broad.mit.edu	37	chr8	71037031	71037031	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactctgtgtatgtgccattCggggtgacataagtgggctc	7	12	14	8	1	1	1	0	1	1	0	3	2	1	1	1	3	1	2	1	3	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:71037031C>A	uc003xyn.1	-	20	4148	c.3986G>T	c.(3985-3987)CGA>CTA	p.R1329L	NCOA2_uc011lfb.1_Missense_Mutation_p.R417L	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1329					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			ATGTGCCATTCGGGGTGACAT	0.512			T	RUNXBP2	AML								48	75					1.51926e-22	2.32492e-22	1	0	A	71037031	A	A	71037031	3	1	238	1	0	0	0	0	1	0	0	0	10283	884	31	3	424	3	NCOA2	8	71037031	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	29484777	71037031	75326991	137	43430											
LY96	23643	broad.mit.edu	37	chr8	74922334	74922334	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttgccgaggatctgatgacGattactctttttgcagagct	8	15	10	8	2	2	3	0	2	2	1	2	6	2	4	1	1	4	2	1	1	1	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:74922334G>C	uc003yad.2	+	3	392	c.301G>C	c.(301-303)GAT>CAT	p.D101H		NM_015364	NP_056179	Q9Y6Y9	LY96_HUMAN	MD-2 protein precursor	101					cellular defense response|detection of lipopolysaccharide|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	extracellular space|lipopolysaccharide receptor complex|plasma membrane	coreceptor activity|lipopolysaccharide receptor activity|protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0208)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0619)			ATCTGATGACGATTACTCTTT	0.313													8	46					0	0	0	0	C	74922334	C	C	74922334	3	2	238	1	0	0	0	0	1	0	0	0	9153	1058	37	3	311	3	LY96	8	74922334	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3885303	74922334	71441688	138	43431											
PKHD1L1	93035	broad.mit.edu	37	chr8	110457455	110457455	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgttttcattggaaatcAacagttcagagcaatagagg	13	12	10	6	0	3	2	3	0	0	2	3	3	3	3	0	2	3	4	0	2	4	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:110457455A>T	uc003yne.2	+	38	5461	c.5357A>T	c.(5356-5358)CAA>CTA	p.Q1786L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1786	Extracellular (Potential).|IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTGGAAATCAACAGTTCAGA	0.413										HNSCC(38;0.096)			26	58					0	0	0	0	T	110457455	T	T	110457455	3	4	238	1	0	0	0	0	1	0	0	0	12027	130	5	5	5507	5	PKHD1L1	8	110457455	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	35535121	110457455	35906567	139	43432											
CSMD3	114788	broad.mit.edu	37	chr8	113317099	113317099	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccattcacaattcgccatCttccatgttccaagataaag	13	11	5	12	1	2	1	1	0	1	1	5	1	4	1	4	0	1	1	4	0	4	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:113317099C>A	uc003ynu.2	-	52	8276	c.8117G>T	c.(8116-8118)AGA>ATA	p.R2706I	CSMD3_uc003yns.2_Missense_Mutation_p.R1908I|CSMD3_uc003ynt.2_Missense_Mutation_p.R2666I|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2706	Extracellular (Potential).|Sushi 16.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATTCGCCATCTTCCATGTTC	0.393										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	28					0.00909568	0.00972131	1	0	A	113317099	A	A	113317099	3	1	238	1	0	0	0	0	1	0	0	0	3963	913	32	2	3086	2	CSMD3	8	113317099	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	2859644	113317099	33046923	140	43433											
CSMD3	114788	broad.mit.edu	37	chr8	113364743	113364743	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctaggagtttgtggttcagGacaggaatccaaaccaattg	12	10	12	7	0	1	0	1	0	0	0	2	3	2	3	2	4	1	3	2	4	4	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:113364743G>T	uc003ynu.2	-	39	6316	c.6157C>A	c.(6157-6159)CCT>ACT	p.P2053T	CSMD3_uc003yns.2_Missense_Mutation_p.P1255T|CSMD3_uc003ynt.2_Missense_Mutation_p.P2013T|CSMD3_uc011lhx.1_Missense_Mutation_p.P1949T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2053	Extracellular (Potential).|Sushi 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGTGGTTCAGGACAGGAATCC	0.323										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			16	68					1.3612e-06	1.64649e-06	1	0	T	113364743	T	T	113364743	3	4	238	1	0	0	0	0	1	0	0	0	3963	1174	41	2	5098	2	CSMD3	8	113364743	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	47644	113364743	32999279	141	43434											
ATAD2	29028	broad.mit.edu	37	chr8	124349867	124349867	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaagattaaactaatacctCatcagggtcaacaggcttag	16	9	7	9	0	3	1	3	0	0	1	3	1	3	1	1	2	3	1	1	2	7	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:124349867C>T	uc003yqh.3	-	21	3157	c.3049G>A	c.(3049-3051)GAG>AAG	p.E1017K	ATAD2_uc011lii.1_Missense_Mutation_p.E808K|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1017	Bromo.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ACTAATACCTCATCAGGGTCA	0.363													8	40					0	0	0	0	T	124349867	T	T	124349867	3	4	238	1	0	0	0	0	1	0	0	0	1073	835	29	2	1155	2	ATAD2	8	124349867	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	10985124	124349867	22014155	142	43435											
COL22A1	169044	broad.mit.edu	37	chr8	139601515	139601515	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttagggacccttcacattaCccggccgggcagcaaggctg	8	8	12	13	2	1	0	1	0	0	0	1	1	1	1	3	4	2	3	3	4	3	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:139601515C>A	uc003yvd.2	-	65	5309	c.4862G>T	c.(4861-4863)GGT>GTT	p.G1621V	COL22A1_uc011ljo.1_Missense_Mutation_p.G901V	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1621					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTCACATTACCCGGCCGGGC	0.587										HNSCC(7;0.00092)			6	51					0.00116845	0.00128625	1	0	A	139601515	A	A	139601515	3	1	238	1	0	0	0	0	1	0	0	0	3696	507	18	4	22	4	COL22A1	8	139601515	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	15251648	139601515	6762507	143	43436											
FAM83H	286077	broad.mit.edu	37	chr8	144812599	144812599	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agggcacaggaagtctggtgCcccctcggtagcgaggaagc	9	5	16	11	2	1	0	0	0	1	0	2	3	1	2	2	5	3	2	2	5	3	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr8:144812599C>T	uc003yzk.2	-	2	223	c.154G>A	c.(154-156)GCA>ACA	p.A52T	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	52					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AAGTCTGGTGCCCCCTCGGTA	0.627													26	64					0	0	0	0	T	144812599	T	T	144812599	3	4	238	1	0	0	0	0	1	0	0	0	5672	739	26	4	3401	4	FAM83H	8	144812599	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	5211084	144812599	1551423	144	43437											
PRUNE2	158471	broad.mit.edu	37	chr9	79325656	79325656	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggggagtagtctgcagAatgagaagattgctgggact	10	10	16	5	0	1	3	0	1	1	3	1	6	1	5	0	3	3	4	0	3	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr9:79325656A>G	uc010mpk.2	-	8	1658	c.1534T>C	c.(1534-1536)TCT>CCT	p.S512P		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	512					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TAGTCTGCAGAATGAGAAGAT	0.547													20	26					0	0	0	0	G	79325656	G	G	79325656	3	3	238	1	0	0	0	0	1	0	0	0	12703	246	9	5	7780	5	PRUNE2	9	79325656	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08		79325656	61887775	145	43438											
C9orf89	84270	broad.mit.edu	37	chr9	95872917	95872917	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagccacctgcagcggagcgGtgagcgggactgccaggagt	8	4	18	11	3	0	1	0	1	0	0	0	5	0	4	3	4	6	1	3	4	0	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr9:95872917G>T	uc004atd.2	+	3	396	c.218G>T	c.(217-219)GGT>GTT	p.G73V	C9orf89_uc004ate.2_RNA|C9orf89_uc004atf.2_RNA	NM_032310	NP_115686	Q96LW7	BINCA_HUMAN	chromosome 9 open reading frame 89	73	CARD.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|nucleus	CARD domain binding				0						CAGCGGAGCGGTGAGCGGGAC	0.502													46	72					1.4659e-37	2.30437e-37	1	0	T	95872917	T	T	95872917	3	4	238	1	0	0	0	0	1	0	0	0	2515	1261	44	4	228	4	C9orf89	9	95872917	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	16547261	95872917	45340514	146	43439											
GRIN3A	116443	broad.mit.edu	37	chr9	104448969	104448969	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaagttctggttggatcaTggtggctgtggctacagctc	7	12	14	8	0	2	0	1	0	1	0	3	1	2	1	0	5	3	6	0	5	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr9:104448969T>C	uc004bbp.1	-	2	1814	c.1213A>G	c.(1213-1215)ATG>GTG	p.M405V	GRIN3A_uc004bbq.1_Missense_Mutation_p.M405V	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	405	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GGTTGGATCATGGTGGCTGTG	0.468													25	27					0	0	0	0	C	104448969	C	C	104448969	3	2	238	1	0	0	0	0	1	0	0	0	6822	1464	51	5	2166	5	GRIN3A	9	104448969	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	8576052	104448969	36764462	147	43440											
ORM2	5005	broad.mit.edu	37	chr9	117092249	117092250	+	Frame_Shift_Del	DEL	TG	-	-																															gctggaagcccagatcccatTgtgtgccaacctagtaccgg																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr9:117092249_117092250delTG	uc004bil.2	+	1	181_182	c.65_66delTG	c.(64-66)TTGfs	p.L22fs	ORM1_uc011lxo.1_Intron	NM_000608	NP_000599	P19652	A1AG2_HUMAN	orosomucoid 2 precursor	22					acute-phase response|regulation of immune system process|transport	extracellular space	binding				0		Myeloproliferative disorder(63;0.163)				CAGATCCCATTGTGTGCCAACC	0.624													---	---	---								-	117092250	-	-	117092249	7	5	238	1	0	1	0	1	0	0	0	0	11322	1821	63	0	67	0	ORM2	9	117092249	Frame_Shift_Del	DEL	TG	TCGA-CV-7248-01A-11D-2012-08	12643280	117092249	24121182	148	43441											
DEC1	50514	broad.mit.edu	37	chr9	118162697	118162697	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgagggccttcttgccGtgttacacatgatggtaggt	6	13	14	8	1	1	2	0	2	1	0	1	2	1	2	2	4	2	2	2	4	2	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr9:118162697G>T	uc004bjk.1	+	6	592	c.73G>T	c.(73-75)GTG>TTG	p.V25L	DEC1_uc004bjl.1_Intron	NM_017418	NP_059114	Q9P2X7	DEC1_HUMAN	deleted in esophageal cancer 1	25					negative regulation of cell proliferation					ovary(1)	1						ccttcttgccgtgttacacat	0													16	75					1.15088e-07	1.45298e-07	1	0	T	118162697	T	T	118162697	3	4	238	1	0	0	0	0	1	0	0	0	4398	1145	40	3	79	3	DEC1	9	118162697	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1070448	118162697	23050734	149	43442											
DNM1	1759	broad.mit.edu	37	chr9	131001792	131001792	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggacttcataggctttgcCaagtgagtgctcccccaggc	8	9	12	12	0	1	1	1	1	0	0	2	3	2	2	3	3	2	2	3	3	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr9:131001792C>T	uc011mau.1	+	12	1578	c.1491C>T	c.(1489-1491)GCC>GCT	p.A497A	DNM1_uc010mxr.2_Silent_p.A497A|DNM1_uc011mat.1_Silent_p.A497A|DNM1_uc004bub.1_5'Flank|DNM1_uc004buc.1_5'Flank|DNM1_uc004bud.3_5'Flank	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	497					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						TAGGCTTTGCCAAGTGAGTGC	0.398													144	202					0	0	0	0	T	131001792	T	T	131001792	2	4	238	1	0	0	0	0	0	0	0	1	4692	581	21	4		4	DNM1	9	131001792	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	12839095	131001792	10211639	150	43443											
RAPGEF1	2889	broad.mit.edu	37	chr9	134503939	134503939	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aacaggggctgcattacctgCctattgattccaacaggcaa	12	9	9	11	0	0	1	0	1	0	0	1	1	1	1	3	3	5	3	3	3	5	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr9:134503939C>T	uc004cbc.2	-	8	1093	c.963G>A	c.(961-963)AGG>AGA	p.R321R	RAPGEF1_uc004cbb.2_Silent_p.R339R|RAPGEF1_uc010mzm.2_5'Flank|RAPGEF1_uc010mzn.2_Silent_p.R326R|RAPGEF1_uc004cbd.2_Silent_p.R326R	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	321					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GCATTACCTGCCTATTGATTC	0.612													13	31					0	0	0	0	T	134503939	T	T	134503939	2	4	238	1	0	0	0	0	0	0	0	1	13108	738	26	4		4	RAPGEF1	9	134503939	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3502147	134503939	6709492	151	43444											
LHX3	8022	broad.mit.edu	37	chr9	139090618	139090618	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccagcgctgccggccggCgtccttcttcagcctcttct	2	10	9	20	4	4	0	1	0	3	0	5	0	5	0	6	2	3	1	6	2	0	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr9:139090618C>A	uc004cha.2	-	5	752	c.655G>T	c.(655-657)GCC>TCC	p.A219S	LHX3_uc004cgz.2_Missense_Mutation_p.A224S	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	219					inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		TGCCGGCCGGCGTCCTTCTTC	0.706													17	79					9.16793e-09	1.20646e-08	1	0	A	139090618	A	A	139090618	3	1	238	1	0	0	0	0	1	0	0	0	8813	768	27	3	546	3	LHX3	9	139090618	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	4586679	139090618	2122813	152	43445											
EHMT1	79813	broad.mit.edu	37	chr9	140611505	140611505	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaagcgcttttccccagacGccagccgccccaccagccac	8	4	7	22	3	0	1	0	0	0	1	1	1	1	1	9	0	3	1	9	0	1	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr9:140611505G>A	uc011mfc.1	+	3	550	c.513G>A	c.(511-513)ACG>ACA	p.T171T	EHMT1_uc004coa.2_Silent_p.T171T|EHMT1_uc004cob.1_Silent_p.T140T	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	171					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		TTCCCCAGACGCCAGCCGCCC	0.662													36	47					0	0	0	0	A	140611505	A	A	140611505	2	1	238	1	0	0	0	0	0	0	0	1	5005	1074	38	1		1	EHMT1	9	140611505	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1520887	140611505	601926	153	43446											
MRC1	4360	broad.mit.edu	37	chr10	17865310	17865310	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaaagtgaatttcagaaatGggagtgcaaaaatgacacac	20	7	9	5	0	1	3	1	2	0	1	1	4	1	4	0	1	1	1	0	1	6	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:17865310G>A	uc001ipk.2	+	2	402	c.299G>A	c.(298-300)TGG>TAG	p.W100*		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	100	Extracellular (Potential).|Ricin B-type lectin.				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						TTTCAGAAATGGGAGTGCAAA	0.388													19	93					0	0	0	0	A	17865310	A	A	17865310	4	1	238	1	0	0	0	0	0	1	0	0	9809	1357	47	4	305	4	MRC1	10	17865310	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08		17865310	117669437	154	43447											
NRG3	10718	broad.mit.edu	37	chr10	84745309	84745309	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccaaatcagaacgagaggCgcaatttgtcttaagaaatg	16	8	10	7	2	2	3	1	0	1	3	2	4	2	3	1	1	2	1	1	1	5	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:84745309C>T	uc001kco.2	+	9	2066	c.2039C>T	c.(2038-2040)GCG>GTG	p.A680V	NRG3_uc010qlz.1_Missense_Mutation_p.A679V|NRG3_uc001kcp.2_Missense_Mutation_p.A483V|NRG3_uc001kcq.2_Missense_Mutation_p.A330V|NRG3_uc001kcr.2_Missense_Mutation_p.A354V	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	704	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GAACGAGAGGCGCAATTTGTC	0.463													5	36					0	0	0	0	T	84745309	T	T	84745309	3	4	238	1	0	0	0	0	1	0	0	0	10703	768	27	1	2317	1	NRG3	10	84745309	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	66879999	84745309	50789438	155	43448											
GRID1	2894	broad.mit.edu	37	chr10	87487719	87487719	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatttaaagcccagagcctTggccagtgcatccaggacat	12	9	9	11	0	0	1	0	0	0	1	1	2	1	2	4	2	3	1	4	2	3	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:87487719T>G	uc001kdl.1	-	10	1527	c.1426A>C	c.(1426-1428)AAG>CAG	p.K476Q	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.K47Q	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	476	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CCCAGAGCCTTGGCCAGTGCA	0.532										Multiple Myeloma(13;0.14)			21	148					0	0	0	0	G	87487719	G	G	87487719	3	3	238	1	0	0	0	0	1	0	0	0	6810	1821	63	5	1631	5	GRID1	10	87487719	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	2742410	87487719	48047028	156	43449											
CYP26A1	1592	broad.mit.edu	37	chr10	94834702	94834702	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcgccatgcgcatcctacTgggctgcgaaccccaactgg	9	7	10	15	3	0	0	0	0	0	0	2	1	1	0	4	2	5	2	4	2	4	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:94834702T>A	uc001kil.2	+	3	626	c.581T>A	c.(580-582)CTG>CAG	p.L194Q	CYP26A1_uc001kik.1_Missense_Mutation_p.L125Q|CYP26A1_uc001kim.1_Missense_Mutation_p.L92Q	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	194					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)				CGCATCCTACTGGGCTGCGAA	0.657													11	87					0	0	0	0	A	94834702	A	A	94834702	3	1	238	1	0	0	0	0	1	0	0	0	4172	1580	55	5	591	5	CYP26A1	10	94834702	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	7346983	94834702	40700045	157	43450											
RBP4	5950	broad.mit.edu	37	chr10	95360773	95360773	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccaacagcaagagcgcccAcacccacttcatcttgccca	11	5	6	19	2	2	1	1	0	1	1	2	1	2	1	4	0	4	1	4	0	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:95360773A>G	uc001kit.2	-	2	97	c.13T>C	c.(13-15)TGG>CGG	p.W5R		NM_006744	NP_006735	P02753	RET4_HUMAN	retinol-binding protein 4, plasma precursor	5					cardiac muscle tissue development|embryonic organ morphogenesis|embryonic retina morphogenesis in camera-type eye|embryonic skeletal system development|female genitalia morphogenesis|gluconeogenesis|glucose homeostasis|heart trabecula formation|lung development|maintenance of gastrointestinal epithelium|negative regulation of cardiac muscle cell proliferation|positive regulation of immunoglobulin secretion|positive regulation of insulin secretion|response to retinoic acid|retinol metabolic process|urinary bladder development|uterus development|vagina development	extracellular space	protein binding|retinal binding|retinol binding				0		Colorectal(252;0.122)			Vitamin A(DB00162)	AAGAGCGCCCACACCCACTTC	0.637													9	71					0	0	0	0	G	95360773	G	G	95360773	3	3	238	1	0	0	0	0	1	0	0	0	13223	159	6	5	612	5	RBP4	10	95360773	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	526071	95360773	40173974	158	43451											
C10orf12	26148	broad.mit.edu	37	chr10	98743264	98743264	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgcagctctcttgggttgtCgagtagtggaagtggtgatg	7	13	16	5	1	1	1	0	1	1	0	3	3	1	2	0	3	2	4	0	3	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:98743264C>T	uc001kmv.2	+	1	2224	c.2117C>T	c.(2116-2118)TCG>TTG	p.S706L		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	706										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CTTGGGTTGTCGAGTAGTGGA	0.507													12	48					0	0	0	0	T	98743264	T	T	98743264	3	4	238	1	0	0	0	0	1	0	0	0	1595	893	31	1	2119	1	C10orf12	10	98743264	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3382491	98743264	36791483	159	43452											
SORCS1	114815	broad.mit.edu	37	chr10	108389130	108389130	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagtccacttggatgagtGtccgctgaacatcaccctga	11	9	9	12	1	1	3	1	3	0	0	3	4	3	4	3	1	1	1	3	1	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:108389130G>C	uc001kym.2	-	19	2500	c.2492C>G	c.(2491-2493)ACA>AGA	p.T831R	SORCS1_uc001kyl.2_Missense_Mutation_p.T831R|SORCS1_uc009xxs.2_Missense_Mutation_p.T831R|SORCS1_uc001kyn.1_Missense_Mutation_p.T831R|SORCS1_uc001kyo.2_Missense_Mutation_p.T831R	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	831	Lumenal (Potential).|PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TTGGATGAGTGTCCGCTGAAC	0.507													5	25					0	0	0	0	C	108389130	C	C	108389130	3	2	238	1	0	0	0	0	1	0	0	0	14994	1377	48	4	1280	4	SORCS1	10	108389130	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	9645866	108389130	27145617	160	43453											
TECTB	6975	broad.mit.edu	37	chr10	114045943	114045943	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcacctaccactccacctacTtggtgaaccaggctgccttt	8	10	7	16	0	0	1	0	1	0	0	1	1	1	1	6	2	4	2	6	2	3	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:114045943T>A	uc001kzr.1	+	3	382	c.382T>A	c.(382-384)TTG>ATG	p.L128M		NM_058222	NP_478129	Q96PL2	TECTB_HUMAN	tectorin beta precursor	128	ZP.					anchored to membrane|plasma membrane|proteinaceous extracellular matrix					0		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		CTCCACCTACTTGGTGAACCA	0.502													19	73					0	0	0	0	A	114045943	A	A	114045943	3	1	238	1	0	0	0	0	1	0	0	0	15814	1606	56	5	392	5	TECTB	10	114045943	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	5656813	114045943	21488804	161	43454											
MKI67	4288	broad.mit.edu	37	chr10	129903439	129903439	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggtctggttgtggagatCtgcaggctattttggtagtt	5	16	15	5	0	2	1	0	0	2	1	2	2	2	1	0	5	1	5	0	5	2	6	rs148951938		TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:129903439C>A	uc001lke.2	-	13	6860	c.6665G>T	c.(6664-6666)AGA>ATA	p.R2222I	MKI67_uc001lkf.2_Missense_Mutation_p.R1862I|MKI67_uc009yav.1_Missense_Mutation_p.R1797I|MKI67_uc009yaw.1_Missense_Mutation_p.R1372I	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2222	16 X 122 AA approximate repeats.|11.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTGTGGAGATCTGCAGGCTAT	0.493													46	251					1.06522e-23	1.63631e-23	1	0	A	129903439	A	A	129903439	3	1	238	1	0	0	0	0	1	0	0	0	9651	913	32	2	3117	2	MKI67	10	129903439	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	15857496	129903439	5631308	162	43455											
MKI67	4288	broad.mit.edu	37	chr10	129906870	129906870	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attccagttacacgggctgcTgggtccaggatctgctttgg	6	12	13	10	1	1	0	0	0	1	0	3	1	3	1	2	4	3	4	2	4	1	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:129906870T>A	uc001lke.2	-	13	3429	c.3234A>T	c.(3232-3234)CCA>CCT	p.P1078P	MKI67_uc001lkf.2_Silent_p.P718P|MKI67_uc009yav.1_Silent_p.P653P|MKI67_uc009yaw.1_Silent_p.P228P	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1078	16 X 122 AA approximate repeats.|1.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CACGGGCTGCTGGGTCCAGGA	0.557													27	199					0	0	0	0	A	129906870	A	A	129906870	2	1	238	1	0	0	0	0	0	0	0	1	9651	1567	55	5		5	MKI67	10	129906870	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	3431	129906870	5627877	163	43456											
FRG2B	441581	broad.mit.edu	37	chr10	135438829	135438829	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcagtgtcagctgctcaCaggtaagtggagaatggatc	11	9	14	7	0	2	2	2	1	0	1	3	4	2	3	0	3	3	4	0	3	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr10:135438829C>A	uc010qvg.1	-	4	664	c.611G>T	c.(610-612)TGT>TTT	p.C204F		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	204						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CAGCTGCTCACAGGTAAGTGG	0.557													11	74					0.000219431	0.000247627	1	0	A	135438829	A	A	135438829	3	1	238	1	0	0	0	0	1	0	0	0	6081	478	17	4	228	4	FRG2B	10	135438829	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	5531959	135438829	95918	164	43457											
OR56A3	390083	broad.mit.edu	37	chr11	5968817	5968817	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcgtgctctgcctcactGtcatccccaaggtcctgacc	7	10	7	17	1	3	1	2	1	1	0	6	1	5	1	5	1	2	1	5	1	1	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:5968817G>T	uc010qzt.1	+	1	241	c.241G>T	c.(241-243)GTC>TTC	p.V81F		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGCCTCACTGTCATCCCCAA	0.567													37	135					1.60099e-16	2.36058e-16	1	0	T	5968817	T	T	5968817	3	4	238	1	0	0	0	0	1	0	0	0	11188	1377	48	4	243	4	OR56A3	11	5968817	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08		5968817	129037699	165	43458											
PLEKHA7	144100	broad.mit.edu	37	chr11	16847840	16847840	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agcattccattcttctctgcCcgttggggctgtgcctgctg	3	14	11	13	1	2	0	0	0	2	0	4	0	3	0	3	2	4	4	3	2	0	4	rs141499859		TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:16847840C>T	uc001mmo.2	-	10	1185	c.1170G>A	c.(1168-1170)CGG>CGA	p.R390R	PLEKHA7_uc010rcu.1_Silent_p.R390R|PLEKHA7_uc001mmn.2_Silent_p.R98R	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	390					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TCTTCTCTGCCCGTTGGGGCT	0.597													33	75					0	0	0	0	T	16847840	T	T	16847840	2	4	238	1	0	0	0	0	0	0	0	1	12116	610	22	4		4	PLEKHA7	11	16847840	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	10879023	16847840	118158676	166	43459											
LDHC	3948	broad.mit.edu	37	chr11	18451424	18451425	+	Missense_Mutation	DNP	CC	AA	AA																															ctgccatagtccattatagtCctgattgtaaaattcttgtt																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:18451424_18451425CC>AA	uc001mon.3	+	4	497_498	c.385_386CC>AA	c.(385-387)CCT>AAT	p.P129N	LDHC_uc001mom.3_Missense_Mutation_p.P129N|LDHC_uc009yhp.2_Missense_Mutation_p.P129N|LDHC_uc001moo.3_Missense_Mutation_p.P13N|LDHC_uc009yhq.2_Intron|LDHC_uc009yhr.2_Missense_Mutation_p.P13N	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	129					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	CCATTATAGTCCTGATTGTAAA	0.391													12	67					0	0	0	0	AA	18451425	AA	AA	18451424	3	1	238	1	0	0	0	0	1	0	0	0	8742	855	30	2	395	2	LDHC	11	18451424	Missense_Mutation	DNP	CC	TCGA-CV-7248-01A-11D-2012-08	1603584	18451424	116555092	167	43460											
OR4C6	219432	broad.mit.edu	37	chr11	55432837	55432837	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttttttcttaccttcttgtcCcttttggatgtcatgttctc	3	23	5	10	0	4	0	1	0	3	0	6	1	5	1	2	1	1	1	2	1	1	9			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:55432837C>A	uc001nht.3	+	3	460	c.195C>A	c.(193-195)TCC>TCA	p.S65S	OR4C6_uc010rik.1_Silent_p.S65S	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CCTTCTTGTCCCTTTTGGATG	0.448													21	93					2.4624e-09	3.29407e-09	1	0	A	55432837	A	A	55432837	2	1	238	1	0	0	0	0	0	0	0	1	11106	610	22	4		4	OR4C6	11	55432837	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	36981413	55432837	79573679	168	43461											
OR5L2	26338	broad.mit.edu	37	chr11	55595555	55595555	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgattcccatgctgaacccCctgatctacagcctgagaaa	11	9	8	13	0	1	4	0	4	1	1	2	5	2	4	4	0	4	1	4	0	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:55595555C>A	uc001nhy.1	+	1	861	c.861C>A	c.(859-861)CCC>CCA	p.P287P		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TGCTGAACCCCCTGATCTACA	0.443										HNSCC(27;0.073)			10	46					1.76689e-08	2.2879e-08	1	0	A	55595555	A	A	55595555	2	1	238	1	0	0	0	0	0	0	0	1	11225	610	22	4		4	OR5L2	11	55595555	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	162718	55595555	79410961	169	43462											
OR8I2	120586	broad.mit.edu	37	chr11	55860982	55860982	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actttttcctgagcaatttaGcatttattgacatattttac	11	19	4	7	0	0	2	0	2	0	0	1	2	1	2	1	0	3	2	1	0	5	10			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:55860982G>T	uc010rix.1	+	1	199	c.199G>T	c.(199-201)GCA>TCA	p.A67S		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					GAGCAATTTAGCATTTATTGA	0.393													27	136					2.65835e-16	3.90535e-16	1	0	T	55860982	T	T	55860982	3	4	238	1	0	0	0	0	1	0	0	0	11294	971	34	4	201	4	OR8I2	11	55860982	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	265427	55860982	79145534	170	43463											
SLC43A3	29015	broad.mit.edu	37	chr11	57175325	57175325	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcccgatataccagaaagggGtggaagaatgtcagaagaat	16	7	12	6	1	1	4	1	0	0	4	2	6	2	5	2	3	1	0	2	3	7	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:57175325G>A	uc001nkg.2	-	14	1826	c.1416C>T	c.(1414-1416)CAC>CAT	p.H472H	PRG2_uc001nke.2_Intron|SLC43A3_uc001nkh.2_Silent_p.H472H|SLC43A3_uc010rjr.1_Silent_p.H485H|SLC43A3_uc009yme.2_Silent_p.H472H|SLC43A3_uc001nki.2_Silent_p.H472H	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	472	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)	1						CCAGAAAGGGGTGGAAGAATG	0.463													18	44					0	0	0	0	A	57175325	A	A	57175325	2	1	238	1	0	0	0	0	0	0	0	1	14698	1252	44	4		4	SLC43A3	11	57175325	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1314343	57175325	77831191	171	43464											
MS4A12	54860	broad.mit.edu	37	chr11	60269478	60269478	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattatctctggctctctctCtgtgtcagcatccaaggagc	7	14	8	12	0	4	0	1	0	3	0	8	1	5	1	1	2	2	2	1	2	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:60269478C>T	uc001npr.2	+	4	494	c.437C>T	c.(436-438)TCT>TTT	p.S146F		NM_017716	NP_060186	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member	146	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						GGCTCTCTCTCTGTGTCAGCA	0.388													19	103					0	0	0	0	T	60269478	T	T	60269478	3	4	238	1	0	0	0	0	1	0	0	0	9909	913	32	2	447	2	MS4A12	11	60269478	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3094153	60269478	74737038	172	43465											
AHNAK	79026	broad.mit.edu	37	chr11	62297865	62297865	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tacctcaggcaaggacacatCcacatctcccttcaattttg	11	11	5	14	0	3	0	2	0	1	0	5	1	4	1	3	2	1	1	3	2	3	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:62297865C>A	uc001ntl.2	-	5	4324	c.4024G>T	c.(4024-4026)GAT>TAT	p.D1342Y	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1342					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AAGGACACATCCACATCTCCC	0.478													55	233					5.39261e-20	8.12916e-20	1	0	A	62297865	A	A	62297865	3	1	238	1	0	0	0	0	1	0	0	0	414	855	30	2	13768	2	AHNAK	11	62297865	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	2028387	62297865	72708651	173	43466											
CFL1	1072	broad.mit.edu	37	chr11	65623195	65623195	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttaaggggcgcagactcGggggccctggacagaaacac	10	5	14	12	2	1	2	0	0	1	2	2	3	1	3	1	5	1	1	1	5	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:65623195G>T	uc001ofs.2	-	3	552	c.318C>A	c.(316-318)CCC>CCA	p.P106P	CFL1_uc001oft.2_Silent_p.P106P|CFL1_uc001ofu.2_3'UTR	NM_005507	NP_005498	P23528	COF1_HUMAN	cofilin 1 (non-muscle)	106	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding				0				READ - Rectum adenocarcinoma(159;0.169)		GCGCAGACTCGGGGGCCCTGG	0.547													6	33					0.00198382	0.00217199	1	0	T	65623195	T	T	65623195	2	4	238	1	0	0	0	0	0	0	0	1	3305	1103	39	3		3	CFL1	11	65623195	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3325330	65623195	69383321	174	43467											
EFEMP2	30008	broad.mit.edu	37	chr11	65634509	65634509	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tactcccgggggcccgtcacCggccgggcgaggaccagcat	6	4	15	16	5	1	0	1	0	0	0	2	2	2	1	5	5	2	1	5	5	1	1	rs148302546	byFrequency	TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:65634509C>A	uc001ofy.3	-	11	1406	c.1212G>T	c.(1210-1212)CCG>CCT	p.P404P	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Intron	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	404					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		GGCCCGTCACCGGCCGGGCGA	0.612													17	62					1.15919e-05	1.36933e-05	1	0	A	65634509	A	A	65634509	2	1	238	1	0	0	0	0	0	0	0	1	4964	639	23	3		3	EFEMP2	11	65634509	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	11314	65634509	69372007	175	43468											
RBM4	5936	broad.mit.edu	37	chr11	66411238	66411238	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagctgcctccgtgtataatTacgcagagcagaccctgtcc	9	9	9	14	2	0	2	0	0	0	2	2	2	2	2	4	0	4	4	4	0	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:66411238T>C	uc009yrj.2	+	3	1218	c.730T>C	c.(730-732)TAC>CAC	p.Y244H	RBM4_uc009yrk.2_Missense_Mutation_p.Y219H|RBM4_uc001oiw.1_Missense_Mutation_p.Y244H|RBM4_uc001oix.1_Intron|RBM4_uc010rpj.1_Intron|RBM4_uc001oiy.1_Missense_Mutation_p.Y244H|RBM4_uc001oiz.1_Missense_Mutation_p.Y244H	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	244	Interaction with TNPO3.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		CGTGTATAATTACGCAGAGCA	0.577													19	74					0	0	0	0	C	66411238	C	C	66411238	3	2	238	1	0	0	0	0	1	0	0	0	13199	1754	61	5	736	5	RBM4	11	66411238	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	776729	66411238	68595278	176	43469											
C11orf82	220042	broad.mit.edu	37	chr11	82644765	82644765	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagagctttcaaaaaaccTgtattttattcagatcttga	15	14	5	7	0	3	3	2	1	1	2	3	3	3	3	1	0	3	2	1	0	6	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:82644765T>A	uc001ozt.2	+	6	2629	c.2385T>A	c.(2383-2385)CCT>CCA	p.P795P	C11orf82_uc010rsr.1_Silent_p.P494P|C11orf82_uc010rss.1_Silent_p.P494P|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	795					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						TCAAAAAACCTGTATTTTATT	0.343													9	33					0	0	0	0	A	82644765	A	A	82644765	2	1	238	1	0	0	0	0	0	0	0	1	1671	1567	55	5		5	C11orf82	11	82644765	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	16233527	82644765	52361751	177	43470											
USP28	57646	broad.mit.edu	37	chr11	113683178	113683178	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ataggcccaatagtgtccagCatttgcttgtccttcatgaa	10	13	8	10	0	1	1	1	1	0	0	3	1	3	1	3	1	2	2	3	1	4	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:113683178C>A	uc001poh.2	-	16	1825	c.1792G>T	c.(1792-1794)GCT>TCT	p.A598S	USP28_uc001pog.2_Missense_Mutation_p.A306S|USP28_uc010rwy.1_Missense_Mutation_p.A473S|USP28_uc001poi.2_Intron	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	598					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TAGTGTCCAGCATTTGCTTGT	0.433													25	86					4.06085e-26	6.28576e-26	1	0	A	113683178	A	A	113683178	3	1	238	1	0	0	0	0	1	0	0	0	17126	710	25	4	1481	4	USP28	11	113683178	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	31038413	113683178	21323338	178	43471											
ADAMTS15	170689	broad.mit.edu	37	chr11	130319057	130319057	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacagcatttcaggaggaCttttacctacacctgacgcc	11	10	7	13	1	2	1	2	1	0	0	2	3	2	3	3	2	3	1	3	2	2	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:130319057C>T	uc010scd.1	+	1	189	c.189C>T	c.(187-189)GAC>GAT	p.D63D		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	63					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		TTCAGGAGGACTTTTACCTAC	0.612													11	90					0	0	0	0	T	130319057	T	T	130319057	2	4	238	1	0	0	0	0	0	0	0	1	260	564	20	4		4	ADAMTS15	11	130319057	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	16635879	130319057	4687459	179	43472											
SPATA19	219938	broad.mit.edu	37	chr11	133715038	133715038	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atcttactcacttttttcaaCcaatgatgtagtacagacac	13	14	4	10	0	3	2	2	1	1	1	3	2	3	2	1	0	3	2	1	0	5	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr11:133715038C>A	uc001qgv.1	-	2	177	c.126G>T	c.(124-126)TGG>TGT	p.W42C		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	42					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		CTTTTTTCAACCAATGATGTA	0.423													6	36					3.59834e-05	4.18942e-05	1	0	A	133715038	A	A	133715038	3	1	238	1	0	0	0	0	1	0	0	0	15070	508	18	4	397	4	SPATA19	11	133715038	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3395981	133715038	1291478	180	43473											
SLC6A13	6540	broad.mit.edu	37	chr12	333259	333259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaacacgtgagggtacatgtCcaccagcgctgtcaccaggc	10	6	12	13	2	1	1	1	1	0	0	2	2	2	1	3	2	3	2	3	2	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:333259C>T	uc001qic.1	-	11	1263	c.1210G>A	c.(1210-1212)GAC>AAC	p.D404N	SLC6A13_uc009zdj.1_Missense_Mutation_p.D394N|SLC6A13_uc010sdl.1_Missense_Mutation_p.D312N	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	404					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GGGTACATGTCCACCAGCGCT	0.557													6	40					0	0	0	0	T	333259	T	T	333259	3	4	238	1	0	0	0	0	1	0	0	0	14740	855	30	2	618	2	SLC6A13	12	333259	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08		333259	133518636	181	43474											
LPAR5	57121	broad.mit.edu	37	chr12	6729716	6729716	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggttagccagcaggaggcgCacggtcttccgccgccgctg	6	6	15	14	5	1	0	0	0	1	0	2	1	2	1	4	4	2	4	4	4	1	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:6729716C>T	uc009zer.2	-	2	980	c.699G>A	c.(697-699)GTG>GTA	p.V233V	LPAR5_uc001qps.2_Silent_p.V233V|LPAR5_uc010sff.1_Silent_p.V233V	NM_001142961	NP_001136433	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	233	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2						GCAGGAGGCGCACGGTCTTCC	0.697													4	5					0	0	0	0	T	6729716	T	T	6729716	2	4	238	1	0	0	0	0	0	0	0	1	8958	697	25	4		4	LPAR5	12	6729716	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	6396457	6729716	127122179	182	43475											
FOXJ2	55810	broad.mit.edu	37	chr12	8192621	8192621	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggcagcagtgcaccaggacGgcaagccacgatacagctat	13	4	12	12	2	0	0	0	0	0	0	0	2	0	1	2	3	5	5	2	3	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:8192621G>T	uc001qtu.2	+	2	1278	c.193G>T	c.(193-195)GGC>TGC	p.G65C	FOXJ2_uc001qtt.1_Missense_Mutation_p.G65C	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	65					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				Kidney(36;0.0944)		GCACCAGGACGGCAAGCCACG	0.582													18	73					1.78486e-19	2.68061e-19	1	0	T	8192621	T	T	8192621	3	4	238	1	0	0	0	0	1	0	0	0	6046	1116	39	3	195	3	FOXJ2	12	8192621	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1462905	8192621	125659274	183	43476											
PRB2	653247	broad.mit.edu	37	chr12	11546523	11546523	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gacttgttgtctccttgtggGggtggtccttgtggctttcc	1	17	14	9	0	1	0	0	0	1	0	4	1	3	0	3	4	0	2	3	4	0	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:11546523G>T	uc010shk.1	-	3	524	c.489C>A	c.(487-489)CCC>CCA	p.P163P		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTCCTTGTGGGGGTGGTCCTT	0.602													79	649					6.16549e-39	9.72992e-39	1	0	T	11546523	T	T	11546523	2	4	238	1	0	0	0	0	0	0	0	1	12505	1219	43	4		4	PRB2	12	11546523	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3353902	11546523	122305372	184	43477											
ABCC9	10060	broad.mit.edu	37	chr12	21991070	21991070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgagaagtgacagagcagagGgagctgggtactatcgtcaa	13	7	15	6	1	1	4	1	2	0	3	2	6	1	5	0	2	3	3	0	2	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:21991070G>A	uc001rfi.1	-	28	3528	c.3508C>T	c.(3508-3510)CCT>TCT	p.P1170S	ABCC9_uc001rfh.2_Missense_Mutation_p.P1170S|ABCC9_uc001rfj.1_Missense_Mutation_p.P1134S	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1170	Extracellular (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGAGCAGAGGGAGCTGGGTA	0.443													23	70					0	0	0	0	A	21991070	A	A	21991070	3	1	238	1	0	0	0	0	1	0	0	0	59	1232	43	4	1327	4	ABCC9	12	21991070	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	10444547	21991070	111860825	185	43478											
LRRK2	120892	broad.mit.edu	37	chr12	40668693	40668693	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaagtcttataggatacttGattacaaagaagaatgtgtt	15	15	8	3	0	1	3	0	1	1	2	1	4	1	4	0	1	2	1	0	1	8	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:40668693G>T	uc001rmg.3	+	16	1960	c.1839G>T	c.(1837-1839)TTG>TTT	p.L613F	LRRK2_uc001rmh.1_Missense_Mutation_p.L235F	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	613					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TAGGATACTTGATTACAAAGA	0.308													4	42					2.56e-06	3.06896e-06	1	0	T	40668693	T	T	40668693	3	4	238	1	0	0	0	0	1	0	0	0	9083	1281	45	2	1901	2	LRRK2	12	40668693	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	18677623	40668693	93183202	186	43479											
LRRK2	120892	broad.mit.edu	37	chr12	40740560	40740560	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctgcttactttcagggtttCgtgcacctgaagttgccaga	7	14	10	10	1	2	2	1	1	1	1	3	2	2	2	2	1	4	4	2	1	2	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:40740560C>T	uc001rmg.3	+	42	6236	c.6115C>T	c.(6115-6117)CGT>TGT	p.R2039C	LRRK2_uc009zjw.2_Missense_Mutation_p.R877C|LRRK2_uc001rmi.2_Missense_Mutation_p.R872C	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2039	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTCAGGGTTTCGTGCACCTGA	0.373													4	26					0	0	0	0	T	40740560	T	T	40740560	3	4	238	1	0	0	0	0	1	0	0	0	9083	884	31	1	6281	1	LRRK2	12	40740560	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	71867	40740560	93111335	187	43480											
MLL2	8085	broad.mit.edu	37	chr12	49424105	49424105	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggcagaggcagcatcctTggggtgctcccccagctctt	5	8	13	15	1	1	1	0	0	1	1	3	1	3	1	4	4	3	5	4	4	0	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:49424105T>A	uc001rta.3	-	42	13957	c.13957A>T	c.(13957-13959)AAG>TAG	p.K4653*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4653					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCAGCATCCTTGGGGTGCTCC	0.622			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			5	10					0	0	0	0	A	49424105	A	A	49424105	4	1	238	1	0	0	0	0	0	1	0	0	9674	1821	63	5	2708	5	MLL2	12	49424105	Nonsense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	8683545	49424105	84427790	188	43481											
AQP6	363	broad.mit.edu	37	chr12	50367220	50367220	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccccgccgtgacgctggcCttcctcgtaggctcccacat	6	8	9	18	4	0	1	0	1	0	0	3	1	2	1	6	2	1	3	6	2	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:50367220C>T	uc001rvr.1	+	1	601	c.264C>T	c.(262-264)GCC>GCT	p.A88A	AQP6_uc001rvp.1_Intron|AQP6_uc001rvq.1_RNA	NM_001652	NP_001643	Q13520	AQP6_HUMAN	aquaporin 6	88	Cytoplasmic (Potential).				excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity				0						TGACGCTGGCCTTCCTCGTAG	0.657													15	82					0	0	0	0	T	50367220	T	T	50367220	2	4	238	1	0	0	0	0	0	0	0	1	830	668	24	4		4	AQP6	12	50367220	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	943115	50367220	83484675	189	43482											
LIMA1	51474	broad.mit.edu	37	chr12	50594639	50594639	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccattttatgaattttgAtttcgccaccactggctttc	7	17	6	11	1	0	2	0	2	0	0	3	2	1	2	3	1	0	2	3	1	2	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:50594639A>G	uc001rwj.3	-	7	1067	c.893T>C	c.(892-894)ATC>ACC	p.I298T	LIMA1_uc001rwg.3_5'UTR|LIMA1_uc001rwh.3_Missense_Mutation_p.I138T|LIMA1_uc001rwi.3_Missense_Mutation_p.I138T|LIMA1_uc001rwk.3_Missense_Mutation_p.I298T|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	298					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						ATGAATTTTGATTTCGCCACC	0.388													56	243					0	0	0	0	G	50594639	G	G	50594639	3	3	238	1	0	0	0	0	1	0	0	0	8837	333	12	5	1409	5	LIMA1	12	50594639	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	227419	50594639	83257256	190	43483											
OR10A7	121364	broad.mit.edu	37	chr12	55615641	55615641	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaagctagtgtcattgtcctAcactgtcatcacacctatgc	10	12	7	12	0	3	0	3	0	0	0	4	1	4	0	2	0	3	1	2	0	4	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:55615641A>G	uc010spf.1	+	1	833	c.833A>G	c.(832-834)TAC>TGC	p.Y278C		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						TCATTGTCCTACACTGTCATC	0.493													19	54					0	0	0	0	G	55615641	G	G	55615641	3	3	238	1	0	0	0	0	1	0	0	0	10949	391	14	5	835	5	OR10A7	12	55615641	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	5021002	55615641	78236254	191	43484											
RNF41	10193	broad.mit.edu	37	chr12	56600268	56600268	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catgcgcaaatatcatgacaAggcctggctcttgcaccatg	11	9	9	12	1	2	1	1	1	1	0	2	1	2	1	2	2	2	3	2	2	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:56600268A>C	uc001skf.1	-	7	1286	c.917T>G	c.(916-918)CTT>CGT	p.L306R	RNF41_uc001ske.1_Missense_Mutation_p.L235R|RNF41_uc001skg.1_Missense_Mutation_p.L306R|RNF41_uc010sqg.1_Missense_Mutation_p.L241R|RNF41_uc010sqh.1_Missense_Mutation_p.L235R	NM_005785	NP_005776	Q9H4P4	RNF41_HUMAN	ring finger protein 41 isoform 1	306					apoptosis|induction of apoptosis|protein polyubiquitination|regulation of reactive oxygen species metabolic process		protein binding|protein tag|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1						TATCATGACAAGGCCTGGCTC	0.527											OREG0021921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	178					0	0	0	0	C	56600268	C	C	56600268	3	2	238	1	0	0	0	0	1	0	0	0	13559	72	3	5	40	5	RNF41	12	56600268	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	984627	56600268	77251627	192	43485											
ALDH1L2	160428	broad.mit.edu	37	chr12	105446604	105446604	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actcacagatccatctgttgGgttgatagtgtcgtaagtct	9	14	10	8	1	3	2	1	1	2	1	5	2	4	2	1	1	0	3	1	1	2	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:105446604G>T	uc001tlc.2	-	11	1520	c.1393C>A	c.(1393-1395)CCA>ACA	p.P465T	ALDH1L2_uc009zuo.2_5'UTR|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	465	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						CCATCTGTTGGGTTGATAGTG	0.318											OREG0022073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	39					1.76689e-08	2.2879e-08	1	0	T	105446604	T	T	105446604	3	4	238	1	0	0	0	0	1	0	0	0	495	1232	43	4	1430	4	ALDH1L2	12	105446604	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	48846336	105446604	28405291	193	43486											
NAA25	80018	broad.mit.edu	37	chr12	112528566	112528566	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtaaaggatagtcagtgcctGcagtgagttgtcatctgtgg	9	12	14	6	0	3	1	2	1	1	0	3	2	3	2	1	2	2	3	1	2	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr12:112528566G>C	uc001ttm.2	-	3	267	c.247C>G	c.(247-249)CAG>GAG	p.Q83E	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.Q55E|NAA25_uc009zwa.1_Missense_Mutation_p.Q83E	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	83	TPR 3.					cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						GTCAGTGCCTGCAGTGAGTTG	0.423													25	83					0	0	0	0	C	112528566	C	C	112528566	3	2	238	1	0	0	0	0	1	0	0	0	10174	1328	46	4	2759	4	NAA25	12	112528566	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	7081962	112528566	21323329	194	43487											
NOC4L	79050	broad.mit.edu	37	chr12	132631856	132631856	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcgcactcctgaagttcGtgcagctggaaggagcgcac	9	7	13	12	3	1	1	1	1	0	0	3	3	2	3	1	2	4	5	1	2	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr12:132631856G>C	uc001ujz.1	+	4	417	c.376G>C	c.(376-378)GTG>CTG	p.V126L	DDX51_uc001ujy.3_5'Flank	NM_024078	NP_076983	Q9BVI4	NOC4L_HUMAN	nucleolar complex associated 4 homolog	126					rRNA processing	integral to membrane|nuclear membrane|nucleolus	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.2e-08)|Epithelial(86;3.34e-07)|all cancers(50;1.97e-05)		CCTGAAGTTCGTGCAGCTGGA	0.647													3	4					0	0	0	0	C	132631856	C	C	132631856	3	2	238	1	0	0	0	0	1	0	0	0	10569	1145	40	3	390	3	NOC4L	12	132631856	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	20103290	132631856	1220039	195	43488											
FLT1	2321	broad.mit.edu	37	chr13	29007977	29007977	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatcagggtaactccaggtCatttgaactctcgtgttcaa	10	13	8	10	1	5	1	4	1	1	0	7	1	6	1	1	2	2	2	1	2	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr13:29007977C>T	uc001usb.3	-	6	1077	c.792G>A	c.(790-792)ATG>ATA	p.M264I	FLT1_uc010aar.1_Missense_Mutation_p.M264I|FLT1_uc001usc.3_Missense_Mutation_p.M264I|FLT1_uc010tdp.1_Missense_Mutation_p.M264I	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	264	Extracellular (Potential).|Ig-like C2-type 3.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AACTCCAGGTCATTTGAACTC	0.443													10	43					0	0	0	0	T	29007977	T	T	29007977	3	4	238	1	0	0	0	0	1	0	0	0	5973	826	29	2	3587	2	FLT1	13	29007977	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08		29007977	86161901	196	43489											
LRCH1	23143	broad.mit.edu	37	chr13	47279253	47279253	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tttaaacctatatcctatggGatcagcagaagccttagaat	14	12	7	8	0	1	2	1	0	0	2	2	3	2	3	3	1	3	1	3	1	8	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr13:47279253G>A	uc001vbj.2	+	12	1687	c.1451G>A	c.(1450-1452)GGA>GAA	p.G484E	LRCH1_uc010acp.2_Missense_Mutation_p.G484E|LRCH1_uc001vbk.2_Missense_Mutation_p.G484E|LRCH1_uc001vbl.3_Missense_Mutation_p.G484E	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	484										ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TATCCTATGGGATCAGCAGAA	0.284													8	54					0	0	0	0	A	47279253	A	A	47279253	3	1	238	1	0	0	0	0	1	0	0	0	8982	1174	41	2	1497	2	LRCH1	13	47279253	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	18271276	47279253	67890625	197	43490											
FNDC3A	22862	broad.mit.edu	37	chr13	49777296	49777296	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atatttgtttcctacagcccCcaaaatagagaaagtaaatg	16	11	6	8	0	0	1	0	0	0	1	1	2	1	1	3	0	2	2	3	0	8	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr13:49777296C>T	uc001vcm.2	+	25	3463	c.3158C>T	c.(3157-3159)CCC>CTC	p.P1053L	FNDC3A_uc001vcn.2_Missense_Mutation_p.P1053L|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Missense_Mutation_p.P997L	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	1053	Fibronectin type-III 9.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		CCTACAGCCCCCAAAATAGAG	0.303													5	24					0	0	0	0	T	49777296	T	T	49777296	3	4	238	1	0	0	0	0	1	0	0	0	6001	623	22	4	3263	4	FNDC3A	13	49777296	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	2498043	49777296	65392582	198	43491											
CKAP2	26586	broad.mit.edu	37	chr13	53036054	53036054	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccaaagaaacctcggaaGagagaaagtaagtagatata	20	5	10	6	1	0	4	0	0	0	4	1	6	0	5	2	1	2	2	2	1	8	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr13:53036054G>T	uc001vgv.2	+	4	1293	c.1096G>T	c.(1096-1098)GAG>TAG	p.E366*	CKAP2_uc001vgt.2_Nonsense_Mutation_p.E365*|CKAP2_uc001vgu.2_Nonsense_Mutation_p.E365*|CKAP2_uc010tha.1_Nonsense_Mutation_p.E317*	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	366					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		AACCTCGGAAGAGAGAAAGTA	0.343													11	19					6.40141e-05	7.32626e-05	1	0	T	53036054	T	T	53036054	4	4	238	1	0	0	0	0	0	1	0	0	3457	943	33	2	1110	2	CKAP2	13	53036054	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3258758	53036054	62133824	199	43492											
MYO16	23026	broad.mit.edu	37	chr13	109707435	109707435	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctacatttcttcaaagattGgaacgaggagatccagtcac	13	11	8	9	1	4	2	2	0	2	2	5	5	5	3	1	2	2	0	1	2	3	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr13:109707435G>A	uc001vqt.1	+	26	3150	c.3024G>A	c.(3022-3024)TTG>TTA	p.L1008L	MYO16_uc010agk.1_Silent_p.L1030L|MYO16_uc001vqu.1_Silent_p.L808L|MYO16_uc010tjh.1_Silent_p.L520L	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1008	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTCAAAGATTGGAACGAGGAG	0.313													8	30					0	0	0	0	A	109707435	A	A	109707435	2	1	238	1	0	0	0	0	0	0	0	1	10117	1339	47	4		4	MYO16	13	109707435	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	56671381	109707435	5462443	200	43493											
SOX1	6656	broad.mit.edu	37	chr13	112722188	112722188	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcgcaagatggcccaggaGaaccccaagatgcacaactc	13	3	11	14	2	0	3	0	0	0	3	1	4	0	3	3	3	3	2	3	3	4	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr13:112722188G>T	uc001vsb.1	+	1	276	c.216G>T	c.(214-216)GAG>GAT	p.E72D		NM_005986	NP_005977	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	72	HMG box.				chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		TGGCCCAGGAGAACCCCAAGA	0.602													8	42					3.09899e-07	3.84046e-07	1	0	T	112722188	T	T	112722188	3	4	238	1	0	0	0	0	1	0	0	0	15004	933	33	2	218	2	SOX1	13	112722188	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3014753	112722188	2447690	201	43494											
RPGRIP1	57096	broad.mit.edu	37	chr14	21771560	21771560	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaacccattggtctatgcAtgcctaacagtgcccacatc	11	10	6	14	0	1	0	0	0	1	0	2	0	1	0	3	1	5	1	3	1	4	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr14:21771560A>T	uc001wag.2	+	5	658	c.658A>T	c.(658-660)ATG>TTG	p.M220L		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	220					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TGGTCTATGCATGCCTAACAG	0.403													13	31					0	0	0	0	T	21771560	T	T	21771560	3	4	238	1	0	0	0	0	1	0	0	0	13614	217	8	5	676	5	RPGRIP1	14	21771560	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08		21771560	85577980	202	43495											
RABGGTA	5875	broad.mit.edu	37	chr14	24736904	24736904	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacacgcacctcggcatactCcatcttgagcacgctattct	9	10	6	16	3	2	1	0	1	2	0	4	1	3	1	2	1	2	4	2	1	2	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr14:24736904C>T	uc001wof.2	-	13	1737	c.1315G>A	c.(1315-1317)GAG>AAG	p.E439K	RABGGTA_uc001woe.2_RNA|RABGGTA_uc001wog.2_Missense_Mutation_p.E439K|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	439					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		TCGGCATACTCCATCTTGAGC	0.622													8	35					0	0	0	0	T	24736904	T	T	24736904	3	4	238	1	0	0	0	0	1	0	0	0	13032	864	30	2	404	2	RABGGTA	14	24736904	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	2965344	24736904	82612636	203	43496											
PRKD1	5587	broad.mit.edu	37	chr14	30135391	30135391	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagagcgtggggacgaatctGaaagtcttcaaaggtggcgg	11	7	17	6	3	3	2	1	1	2	1	3	5	3	3	0	5	1	0	0	5	3	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr14:30135391G>C	uc001wqh.2	-	3	608	c.427C>G	c.(427-429)CAG>GAG	p.Q143E		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	143					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GGACGAATCTGAAAGTCTTCA	0.408													12	43					0	0	0	0	C	30135391	C	C	30135391	3	2	238	1	0	0	0	0	1	0	0	0	12580	1299	45	2	2375	2	PRKD1	14	30135391	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	5398487	30135391	77214149	204	43497											
NID2	22795	broad.mit.edu	37	chr14	52520359	52520359	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acgtccctcgacttaagggtGtagtgtgacctgaagcaggg	9	9	14	9	2	0	2	0	2	0	0	2	3	1	2	2	2	1	2	2	2	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr14:52520359G>A	uc001wzo.2	-	5	1601	c.1367C>T	c.(1366-1368)ACA>ATA	p.T456I	NID2_uc010tqs.1_Missense_Mutation_p.T456I|NID2_uc010tqt.1_Missense_Mutation_p.T456I|NID2_uc001wzp.2_Missense_Mutation_p.T456I	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	456						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					ACTTAAGGGTGTAGTGTGACC	0.498													37	125					0	0	0	0	A	52520359	A	A	52520359	3	1	238	1	0	0	0	0	1	0	0	0	10469	1377	48	4	2832	4	NID2	14	52520359	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	22384968	52520359	54829181	205	43498											
DACT1	51339	broad.mit.edu	37	chr14	59112196	59112196	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagagcccaatgtttctcctTtgtctgacgggcaaccctct	7	12	8	14	1	3	2	0	1	3	1	4	2	3	2	3	1	2	2	3	1	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr14:59112196T>C	uc001xdw.2	+	4	1019	c.855T>C	c.(853-855)CTT>CTC	p.L285L	DACT1_uc010trv.1_Silent_p.L4L|DACT1_uc001xdx.2_Silent_p.L248L|DACT1_uc010trw.1_Silent_p.L4L	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	285					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						TGTTTCTCCTTTGTCTGACGG	0.502													13	67					0	0	0	0	C	59112196	C	C	59112196	2	2	238	1	0	0	0	0	0	0	0	1	4239	1828	64	5		5	DACT1	14	59112196	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	6591837	59112196	48237344	206	43499											
SYT16	83851	broad.mit.edu	37	chr14	62547851	62547851	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagagatgtggctgcctgTgctgtccgcttccgcctgta	4	11	12	14	2	0	1	0	0	0	1	2	2	2	1	5	1	2	4	5	1	1	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr14:62547851T>C	uc001xfu.1	+	4	1490	c.1293T>C	c.(1291-1293)TGT>TGC	p.C431C	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_5'UTR	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	431	C2 1.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TGGCTGCCTGTGCTGTCCGCT	0.572													6	23					0	0	0	0	C	62547851	C	C	62547851	2	2	238	1	0	0	0	0	0	0	0	1	15538	1702	59	5		5	SYT16	14	62547851	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	3435655	62547851	44801689	207	43500											
PPP4R4	57718	broad.mit.edu	37	chr14	94640869	94640869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcctgttcggttacatggagGacctgcaggagctcaccatc	8	9	12	12	1	1	0	1	0	0	0	3	3	1	3	3	4	3	4	3	4	1	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr14:94640869G>A	uc001ycs.1	+	1	221	c.67G>A	c.(67-69)GAC>AAC	p.D23N	PPP4R4_uc001ycr.2_Missense_Mutation_p.D23N	NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	23						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TTACATGGAGGACCTGCAGGA	0.617													19	36					0	0	0	0	A	94640869	A	A	94640869	3	1	238	1	0	0	0	0	1	0	0	0	12465	1174	41	2	69	2	PPP4R4	14	94640869	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	32093018	94640869	12708671	208	43501											
RTL1	388015	broad.mit.edu	37	chr14	101349302	101349302	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcgcggtggagggacactcGtaaaaggtctcgctgtgatc	8	8	16	9	4	1	1	0	1	1	0	4	3	1	3	0	5	0	2	0	5	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr14:101349302G>T	uc010txj.1	-	1	1883	c.1824C>A	c.(1822-1824)TAC>TAA	p.Y608*	uc001yig.3_5'Flank|MIR127_hsa-mir-127|MI0000472_5'Flank|MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	608										pancreas(1)	1						AGGGACACTCGTAAAAGGTCT	0.567													8	35					3.09899e-07	3.84046e-07	1	0	T	101349302	T	T	101349302	4	4	238	1	0	0	0	0	0	1	0	0	13789	1140	40	3	2256	3	RTL1	14	101349302	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	6708433	101349302	6000238	209	43502											
OR4M2	390538	broad.mit.edu	37	chr15	22369359	22369359	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	catccatctacatttatgctCgcccatttgactcgttttcc	7	16	4	14	2	1	1	0	1	1	0	5	1	3	1	3	0	2	2	3	0	2	6	rs145231732		TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr15:22369359C>G	uc010tzu.1	+	1	784	c.784C>G	c.(784-786)CGC>GGC	p.R262G	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CATTTATGCTCGCCCATTTGA	0.418													6	141					0	0	0	0	G	22369359	G	G	22369359	3	3	238	1	0	0	0	0	1	0	0	0	11130	884	31	3	786	3	OR4M2	15	22369359	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08		22369359	80162033	210	43503											
SNRPN	6638	broad.mit.edu	37	chr15	25222051	25222052	+	Missense_Mutation	DNP	GG	TT	TT																															ttgctcgggtaccacttgctGgagctgctggaggccctggg																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr15:25222051_25222052GG>TT	uc001ywp.1	+	10	1185_1186	c.295_296GG>TT	c.(295-297)GGA>TTA	p.G99L	SNRPN_uc001ywq.1_Missense_Mutation_p.G99L|SNRPN_uc001ywr.1_Missense_Mutation_p.G99L|SNRPN_uc001yws.1_Missense_Mutation_p.G99L|SNRPN_uc001ywt.1_Missense_Mutation_p.G99L|SNRPN_uc001ywv.1_Missense_Mutation_p.G102L|SNRPN_uc001yww.1_Missense_Mutation_p.G99L|SNRPN_uc001ywx.1_Missense_Mutation_p.G99L|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	99					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		ACCACTTGCTGGAGCTGCTGGA	0.51									Prader-Willi_syndrome				13	75					0	0	0	0	TT	25222052	TT	TT	25222051	3	4	238	1	0	0	0	0	1	0	0	0	14934	1349	47	4	309	4	SNRPN	15	25222051	Missense_Mutation	DNP	GG	TCGA-CV-7248-01A-11D-2012-08	2852692	25222051	77309341	211	43504											
ONECUT1	3175	broad.mit.edu	37	chr15	53050034	53050034	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcccatgttcttgttctttCcttttgcatgctgtgaagaa	6	19	7	9	0	2	2	0	1	2	1	4	2	4	2	2	0	2	4	2	0	2	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr15:53050034C>T	uc002aci.1	-	2	1244	c.1116G>A	c.(1114-1116)AGG>AGA	p.R372R		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	372					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		CTTGTTCTTTCCTTTTGCATG	0.423													17	95					0	0	0	0	T	53050034	T	T	53050034	2	4	238	1	0	0	0	0	0	0	0	1	10922	854	30	2		2	ONECUT1	15	53050034	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	27827983	53050034	49481358	212	43505											
UNC13C	440279	broad.mit.edu	37	chr15	54847645	54847645	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaggagcacatgattcgaGaggatgccaggggtctgacg	10	7	15	9	2	1	3	0	2	1	1	3	6	2	5	2	4	2	1	2	4	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr15:54847645G>T	uc002ack.2	+	27	5893	c.5893G>T	c.(5893-5895)GAG>TAG	p.E1965*		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1965	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CATGATTCGAGAGGATGCCAG	0.413													6	45					8.12818e-05	9.27623e-05	1	0	T	54847645	T	T	54847645	4	4	238	1	0	0	0	0	0	1	0	0	17054	943	33	2	5999	2	UNC13C	15	54847645	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1797611	54847645	47683747	213	43506											
CCPG1	9236	broad.mit.edu	37	chr15	55657499	55657499	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgttgacgcttctgaatctGaattgtgcctaaaataaata	13	14	7	7	1	2	3	0	3	2	0	2	3	2	3	1	0	1	2	1	0	7	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr15:55657499G>A	uc002acv.1	-	7	880	c.715C>T	c.(715-717)CAG>TAG	p.Q239*	CCPG1_uc002acy.2_Nonsense_Mutation_p.Q239*|CCPG1_uc002acu.1_Nonsense_Mutation_p.Q95*|CCPG1_uc002acw.1_Intron|CCPG1_uc002acx.2_Nonsense_Mutation_p.Q239*|CCPG1_uc010bfk.1_Nonsense_Mutation_p.Q239*|CCPG1_uc002acz.1_Nonsense_Mutation_p.Q239*	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	239	Lumenal (Potential).|Interaction with MCF2L and SRC (By similarity).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		TTCTGAATCTGAATTGTGCCt	0.234													15	70					0	0	0	0	A	55657499	A	A	55657499	4	1	238	1	0	0	0	0	0	1	0	0	2953	1299	45	2	1566	2	CCPG1	15	55657499	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	809854	55657499	46873893	214	43507											
VPS13C	54832	broad.mit.edu	37	chr15	62217667	62217667	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtactaaccttaattataaaTtctttaaccataatatttat	16	18	1	6	0	1	0	0	0	1	0	1	0	1	0	2	0	3	1	2	0	10	12			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr15:62217667T>G	uc002agz.2	-	53	6671	c.6597A>C	c.(6595-6597)GAA>GAC	p.E2199D	VPS13C_uc002aha.2_Missense_Mutation_p.E2156D|VPS13C_uc002ahb.1_Missense_Mutation_p.E2199D|VPS13C_uc002ahc.1_Missense_Mutation_p.E2156D	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2199					protein localization					ovary(2)	2						TAATTATAAATTCTTTAACCA	0.294													3	5					0	0	0	0	G	62217667	G	G	62217667	3	3	238	1	0	0	0	0	1	0	0	0	17259	1490	52	5	4824	5	VPS13C	15	62217667	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	6560168	62217667	40313725	215	43508											
KIAA1024	23251	broad.mit.edu	37	chr15	79748907	79748907	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgtgagcccctgaactgtGagctgagtgagaggtctttc	8	11	14	8	0	1	5	0	5	1	1	2	6	1	5	2	1	3	1	2	1	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr15:79748907G>A	uc002bew.1	+	2	493	c.418G>A	c.(418-420)GAG>AAG	p.E140K	KIAA1024_uc010unk.1_Missense_Mutation_p.E140K	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	140						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						CCTGAACTGTGAGCTGAGTGA	0.577													9	82					0	0	0	0	A	79748907	A	A	79748907	3	1	238	1	0	0	0	0	1	0	0	0	8244	1291	45	2	420	2	KIAA1024	15	79748907	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	17531240	79748907	22782485	216	43509											
ACAN	176	broad.mit.edu	37	chr15	89417692	89417692	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacggcaccctcggaggagcCgccccagcacagcccactga	9	2	11	19	3	0	1	0	1	0	0	1	3	0	3	5	3	3	2	5	3	0	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr15:89417692C>A	uc010upo.1	+	18	7947	c.7573C>A	c.(7573-7575)CGC>AGC	p.R2525S	ACAN_uc010upp.1_Missense_Mutation_p.R2426S|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2525					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TCGGAGGAGCCGCCCCAGCAC	0.617													4	13					0.00909568	0.00972131	1	0	A	89417692	A	A	89417692	3	1	238	1	0	0	0	0	1	0	0	0	117	652	23	3	7639	3	ACAN	15	89417692	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	9668785	89417692	13113700	217	43510											
CNOT1	23019	broad.mit.edu	37	chr16	58612676	58612676	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggaaaattggcatcagagtgGagataagttcatggcgcaag	14	8	14	5	1	2	2	2	0	0	2	2	4	2	3	0	4	0	3	0	4	4	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr16:58612676G>C	uc002env.2	-	13	1804	c.1511C>G	c.(1510-1512)TCC>TGC	p.S504C	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.S504C|CNOT1_uc002enx.2_Missense_Mutation_p.S504C|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	504					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CATCAGAGTGGAGATAAGTTC	0.448													9	65					0	0	0	0	C	58612676	C	C	58612676	3	2	238	1	0	0	0	0	1	0	0	0	3632	1174	41	2	5989	2	CNOT1	16	58612676	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08		58612676	31742077	218	43511											
SMPD3	55512	broad.mit.edu	37	chr16	68395622	68395622	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgagctcttgctggtgggaaAcgccaggtactccctgcggc	6	8	14	13	3	1	0	0	0	1	0	2	2	2	1	2	4	5	3	2	4	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr16:68395622A>T	uc002ewa.2	-	8	2172	c.1750T>A	c.(1750-1752)TTT>ATT	p.F584I	SMPD3_uc010cfe.2_Intron|SMPD3_uc010vlh.1_Missense_Mutation_p.F576I	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	584	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	CTGGTGGGAAACGCCAGGTAC	0.682													20	57					0	0	0	0	T	68395622	T	T	68395622	3	4	238	1	0	0	0	0	1	0	0	0	14870	43	2	5	225	5	SMPD3	16	68395622	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	9782946	68395622	21959131	219	43512											
PMFBP1	83449	broad.mit.edu	37	chr16	72188257	72188257	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttgttgaaggaccagcaaTtttttcttcagttgctggag	8	16	10	7	0	3	1	1	1	2	0	3	3	3	3	1	2	2	4	1	2	2	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr16:72188257T>A	uc002fcc.3	-	4	439	c.267A>T	c.(265-267)AAA>AAT	p.K89N	PMFBP1_uc002fcd.2_Missense_Mutation_p.K89N|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_5'UTR	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	89	Potential.									ovary(2)	2		Ovarian(137;0.179)				GGACCAGCAATTTTTTCTTCA	0.453													17	88					0	0	0	0	A	72188257	A	A	72188257	3	1	238	1	0	0	0	0	1	0	0	0	12189	1490	52	5	2888	5	PMFBP1	16	72188257	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	3792635	72188257	18166496	220	43513											
PKD1L2	114780	broad.mit.edu	37	chr16	81236234	81236234	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtctccatcttgtctcgcacGgtcacctgcctctgagctgt	4	13	9	15	2	5	1	1	1	4	0	7	1	5	1	3	1	2	2	3	1	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr16:81236234G>A	uc002fgh.1	-	6	1014	c.1014C>T	c.(1012-1014)ACC>ACT	p.T338T	PKD1L2_uc002fgj.2_Silent_p.T338T	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	338	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGTCTCGCACGGTCACCTGCC	0.582													20	60					0	0	0	0	A	81236234	A	A	81236234	2	1	238	1	0	0	0	0	0	0	0	1	12020	1103	39	1		1	PKD1L2	16	81236234	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	9047977	81236234	9118519	221	43514											
TP53	7157	broad.mit.edu	37	chr17	7577556	7577556	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccggttcatgccgcccatgCaggaactgttacacatgtag	9	10	10	12	2	1	0	1	0	0	0	2	1	2	1	3	2	4	4	3	2	3	3	rs121912655		TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:7577556C>A	uc002gim.2	-	7	919	c.725G>T	c.(724-726)TGC>TTC	p.C242F	TP53_uc002gig.1_Missense_Mutation_p.C242F|TP53_uc002gih.2_Missense_Mutation_p.C242F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C110F|TP53_uc010cng.1_Missense_Mutation_p.C110F|TP53_uc002gii.1_Missense_Mutation_p.C110F|TP53_uc010cnh.1_Missense_Mutation_p.C242F|TP53_uc010cni.1_Missense_Mutation_p.C242F|TP53_uc002gij.2_Missense_Mutation_p.C242F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C149F|TP53_uc002gio.2_Missense_Mutation_p.C110F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	242	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).	Zinc.	C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(63)|p.C242Y(37)|p.C242S(25)|p.C242fs*5(16)|p.C242R(11)|p.C242W(7)|p.0?(7)|p.N239_C242delNSSC(3)|p.C242*(3)|p.C242C(2)|p.C242G(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241_G245delSCMGG(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGCCCATGCAGGAACTGTT	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	44					3.00307e-07	3.74456e-07	1	0	A	7577556	A	A	7577556	3	1	238	1	0	0	0	0	1	0	0	0	16448	710	25	4	565	4	TP53	17	7577556	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08		7577556	73617654	222	43515											
NTN1	9423	broad.mit.edu	37	chr17	8926249	8926249	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgccgcaagatgtacaacCggccgcaccgcgcgcccatc	9	4	11	17	6	0	1	0	0	0	1	1	1	0	1	5	1	3	3	5	1	3	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:8926249C>A	uc002glw.3	+	2	666	c.559C>A	c.(559-561)CGG>AGG	p.R187R		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	187	Laminin N-terminal.				apoptosis|axon guidance		protein binding				0						GATGTACAACCGGCCGCACCG	0.667													4	21					0.00909568	0.00972131	1	0	A	8926249	A	A	8926249	2	1	238	1	0	0	0	0	0	0	0	1	10754	643	23	3		3	NTN1	17	8926249	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1348693	8926249	72268961	223	43516											
MYH8	4626	broad.mit.edu	37	chr17	10305003	10305003	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgatctcttcctcctcctCagctctttcagtcacctctt	5	17	3	16	0	6	1	3	1	3	0	10	1	9	1	4	0	1	1	4	0	0	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:10305003C>G	uc002gmm.2	-	23	2883	c.2788G>C	c.(2788-2790)GAG>CAG	p.E930Q	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	930	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TCCTCCTCCTCAGCTCTTTCA	0.443									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				38	273					0	0	0	0	G	10305003	G	G	10305003	3	3	238	1	0	0	0	0	1	0	0	0	10094	835	29	2	3097	2	MYH8	17	10305003	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1378754	10305003	70890207	224	43517											
ACCN1	40	broad.mit.edu	37	chr17	31439077	31439077	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtaacacttcccatatttTgtaaacacctgaaggagaga	15	11	7	8	0	0	2	0	1	0	1	1	4	1	3	2	1	2	2	2	1	5	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:31439077T>C	uc002hhu.2	-	2	838	c.564A>G	c.(562-564)ACA>ACG	p.T188T	ACCN1_uc002hht.2_Silent_p.T239T	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	188	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	TCCCATATTTTGTAAACACCT	0.527													7	38					0	0	0	0	C	31439077	C	C	31439077	2	2	238	1	0	0	0	0	0	0	0	1	128	1799	63	5		5	ACCN1	17	31439077	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	21134074	31439077	49756133	225	43518											
LYZL6	57151	broad.mit.edu	37	chr17	34263770	34263770	+	Frame_Shift_Del	DEL	C	-	-																															cctcctcaccagttgttcatCccccgtgctccggacacaat																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:34263770delC	uc002hkj.1	-	3	516	c.366delG	c.(364-366)GGGfs	p.G122fs	LYZL6_uc002hkk.1_Frame_Shift_Del_p.G122fs	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor	122					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGTTGTTCATCCCCCGTGCTC	0.572													---	---	---								-	34263770	-	-	34263770	7	5	238	1	0	1	0	1	0	0	0	0	9185	842	30	0	88	0	LYZL6	17	34263770	Frame_Shift_Del	DEL	C	TCGA-CV-7248-01A-11D-2012-08	2824693	34263770	46931440	226	43519											
LHX1	3975	broad.mit.edu	37	chr17	35298160	35298160	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcagctggcgcaggagacCggcctcaacatgcgcgtcat	9	5	14	13	4	2	1	2	0	0	1	2	3	2	1	2	3	4	3	2	3	1	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:35298160C>A	uc002hnh.1	+	3	1647	c.651C>A	c.(649-651)ACC>ACA	p.T217T	LHX1_uc010cux.1_Silent_p.T125T	NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	217	Homeobox.				cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				CGCAGGAGACCGGCCTCAACA	0.672													4	13					0.00909568	0.00972131	1	0	A	35298160	A	A	35298160	2	1	238	1	0	0	0	0	0	0	0	1	8811	639	23	3		3	LHX1	17	35298160	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1034390	35298160	45897050	227	43520											
MED24	9862	broad.mit.edu	37	chr17	38184186	38184186	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcgctgccataggttgTgaattcattcaaactgaaag	11	14	8	8	1	3	2	2	2	1	0	4	2	3	2	1	1	2	2	1	1	4	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:38184186T>A	uc002htt.2	-	15	1736	c.1423A>T	c.(1423-1425)ACA>TCA	p.T475S	MED24_uc010wes.1_Missense_Mutation_p.T335S|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Missense_Mutation_p.T500S|MED24_uc002htu.2_Missense_Mutation_p.T462S|MED24_uc010cwn.2_Missense_Mutation_p.T462S|MED24_uc010weu.1_Missense_Mutation_p.T385S|MED24_uc010wev.1_Missense_Mutation_p.T425S|MED24_uc010wew.1_Missense_Mutation_p.T416S|MED24_uc010wex.1_Missense_Mutation_p.T180S	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	475					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					CCATAGGTTGTGAATTCATTC	0.577													4	130					0	0	0	0	A	38184186	A	A	38184186	3	1	238	1	0	0	0	0	1	0	0	0	9495	1696	59	5	1594	5	MED24	17	38184186	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	2886026	38184186	43011024	228	43521											
KRTAP4-1	85285	broad.mit.edu	37	chr17	39343284	39343298	+	5'Flank	DEL	GCAGCAGGTGGTCTG	-	-																															cggcagcagcaagcggtcttGcagcaggtggtctggcagca																								rs67744591		TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr17:39343284_39343298delGCAGCAGGTGGTCTG	uc002hwe.3	-						KRTAP4-1_uc010cxm.1_Intron	NM_033060	NP_149049	Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1							keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			AAGCGGTCTTGCAGCAGGTGGTCTGGCAGCAGCTG	0.549													---	---	---								-	39343298	-	-	39343284	6	5	238	0	1	1	0	1	0	0	0	0	8588	1334	46	0		0	KRTAP4-1	17	39343284	5'Flank	DEL	GCAGCAGGTGGTCTG	TCGA-CV-7248-01A-11D-2012-08	1159098	39343284	41851926	229	43522											
BRCA1	672	broad.mit.edu	37	chr17	41245558	41245558	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccatgagttgtaggtttcTgctgtgcctgactggcattt	5	17	11	8	0	1	2	0	2	1	0	2	2	2	2	2	2	2	5	2	2	1	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:41245558T>C	uc002icq.2	-	10	2222	c.1990A>G	c.(1990-1992)AGA>GGA	p.R664G	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.R593G|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.R617G|BRCA1_uc002ict.2_Missense_Mutation_p.R664G|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.R664G|BRCA1_uc002ide.1_Missense_Mutation_p.R495G|BRCA1_uc010cyy.1_Missense_Mutation_p.R664G|BRCA1_uc010whs.1_Missense_Mutation_p.R664G|BRCA1_uc010cyz.2_Missense_Mutation_p.R617G|BRCA1_uc010cza.2_Missense_Mutation_p.R638G|BRCA1_uc010wht.1_Missense_Mutation_p.R368G	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	664					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGTAGGTTTCTGCTGTGCCTG	0.393			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			16	96					0	0	0	0	C	41245558	C	C	41245558	3	2	238	1	0	0	0	0	1	0	0	0	1503	1588	55	5	3727	5	BRCA1	17	41245558	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	1902274	41245558	39949652	230	43523											
CDC27	996	broad.mit.edu	37	chr17	45219297	45219297	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtattgtagtggtgagaaggTagatggctcaaaatatttat	13	14	12	2	0	1	2	1	1	0	2	1	3	1	2	0	3	0	4	0	3	8	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:45219297T>G	uc002ild.3	-	12	1600	c.1473A>C	c.(1471-1473)CTA>CTC	p.L491L	CDC27_uc002ile.3_Silent_p.L497L|CDC27_uc002ilf.3_Silent_p.L490L|CDC27_uc010wkp.1_Silent_p.L430L|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	491					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						GGTGAGAAGGTAGATGGCTCA	0.378													4	158					0	0	0	0	G	45219297	G	G	45219297	2	3	238	1	0	0	0	0	0	0	0	1	3081	1625	57	5		5	CDC27	17	45219297	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	3973739	45219297	35975913	231	43524											
STRADA	92335	broad.mit.edu	37	chr17	61791420	61791420	+	Frame_Shift_Del	DEL	C	-	-																															tggcagaaagctactcatgaCctcctgtttagagaaggatg																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:61791420delC	uc002jbm.2	-	5	331	c.172delG	c.(172-174)GTCfs	p.V58fs	STRADA_uc002jbn.2_5'UTR|STRADA_uc002jbo.2_Frame_Shift_Del_p.V21fs|STRADA_uc002jbp.2_Frame_Shift_Del_p.V21fs|STRADA_uc002jbq.2_5'UTR|STRADA_uc010wpq.1_Intron|STRADA_uc010wpr.1_Frame_Shift_Del_p.V29fs|STRADA_uc010ddw.2_Frame_Shift_Del_p.V29fs|STRADA_uc002jbr.2_5'UTR	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	58					activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						CTACTCATGACCTCCTGTTTA	0.488													---	---	---								-	61791420	-	-	61791420	7	5	238	1	0	1	0	1	0	0	0	0	15390	507	18	0	1217	0	STRADA	17	61791420	Frame_Shift_Del	DEL	C	TCGA-CV-7248-01A-11D-2012-08	16572123	61791420	19403790	232	43525											
GRIN2C	2905	broad.mit.edu	37	chr17	72846860	72846860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaggcactgtagcgaggcCacacggggtacttcatgtat	10	8	14	9	2	1	1	1	0	0	1	1	3	1	1	1	4	2	4	1	4	3	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr17:72846860C>G	uc002jlt.1	-	5	1316	c.1160G>C	c.(1159-1161)TGG>TCG	p.W387S	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.W387S|GRIN2C_uc002jlv.1_3'UTR	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	387	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GTAGCGAGGCCACACGGGGTA	0.657													8	19					0	0	0	0	G	72846860	G	G	72846860	3	3	238	1	0	0	0	0	1	0	0	0	6820	595	21	4	2577	4	GRIN2C	17	72846860	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	11055440	72846860	8348350	233	43526											
PTPRM	5797	broad.mit.edu	37	chr18	7949203	7949203	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgatgtgcgagatgctcctCtgaaggaaatcaaggtgacc	11	10	12	8	1	2	4	1	3	1	1	3	6	3	5	2	2	2	1	2	2	3	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr18:7949203C>T	uc002knn.3	+	6	1191	c.688C>T	c.(688-690)CTG>TTG	p.L230L	PTPRM_uc010dkv.2_Silent_p.L230L|PTPRM_uc010wzl.1_Silent_p.L17L	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	230	Ig-like C2-type.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				AGATGCTCCTCTGAAGGAAAT	0.473													13	78					0	0	0	0	T	7949203	T	T	7949203	2	4	238	1	0	0	0	0	0	0	0	1	12871	912	32	2		2	PTPRM	18	7949203	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08		7949203	70128045	234	43527											
CDH19	28513	broad.mit.edu	37	chr18	64178851	64178851	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaattgttagtgtcttctacAgatagattaaagtaaaaatg	16	14	8	3	0	2	2	0	0	2	2	2	3	2	2	0	0	1	2	0	0	9	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr18:64178851A>T	uc002lkc.1	-	10	1668	c.1530T>A	c.(1528-1530)TCT>TCA	p.S510S	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Intron	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	510	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TGTCTTCTACAGATAGATTAA	0.308													9	30					0	0	0	0	T	64178851	T	T	64178851	2	4	238	1	0	0	0	0	0	0	0	1	3119	175	7	5		5	CDH19	18	64178851	Silent	SNP	A	TCGA-CV-7248-01A-11D-2012-08	56229648	64178851	13898397	235	43528											
CDH19	28513	broad.mit.edu	37	chr18	64202257	64202257	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtaatacttaggttgtaccaAgcactgatttcacgatccag	12	12	8	9	1	1	1	1	1	0	0	2	2	2	1	2	1	3	4	2	1	5	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr18:64202257A>T	uc002lkc.1	-	8	1440	c.1302T>A	c.(1300-1302)GCT>GCA	p.A434A	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Silent_p.A434A|CDH19_uc002lkd.2_Silent_p.A434A	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	434	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				GGTTGTACCAAGCACTGATTT	0.323													6	28					0	0	0	0	T	64202257	T	T	64202257	2	4	238	1	0	0	0	0	0	0	0	1	3119	59	3	5		5	CDH19	18	64202257	Silent	SNP	A	TCGA-CV-7248-01A-11D-2012-08	23406	64202257	13874991	236	43529											
DOK6	220164	broad.mit.edu	37	chr18	67266726	67266726	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatcgaagacatttgcctGtgagtcaggtaagctattat	13	12	9	7	1	1	2	1	1	0	1	2	3	1	2	1	1	3	2	1	1	5	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr18:67266726G>T	uc002lkl.2	+	3	471	c.281G>T	c.(280-282)TGT>TTT	p.C94F		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	94	PH.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				ACATTTGCCTGTGAGTCAGGT	0.448													5	19					5.9392e-07	7.29312e-07	1	0	T	67266726	T	T	67266726	3	4	238	1	0	0	0	0	1	0	0	0	4723	1377	48	4	291	4	DOK6	18	67266726	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3064469	67266726	10810522	237	43530											
HMHA1	23526	broad.mit.edu	37	chr19	1080953	1080953	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagtggaccgttccgccacGaggggctgtccaaggcggcc	6	5	15	15	4	0	0	0	0	0	0	2	2	2	1	6	5	0	2	6	5	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:1080953G>A	uc002lqz.1	+	17	2311	c.2080G>A	c.(2080-2082)GAG>AAG	p.E694K	HMHA1_uc010xgd.1_Missense_Mutation_p.E710K|HMHA1_uc010xge.1_Missense_Mutation_p.E562K|HMHA1_uc002lra.1_Missense_Mutation_p.E534K|HMHA1_uc002lrb.1_Missense_Mutation_p.E577K|HMHA1_uc002lrc.1_Missense_Mutation_p.E329K|HMHA1_uc002lrd.1_5'Flank|HMHA1_uc010dsd.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	694					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTTCCGCCACGAGGGGCTGTC	0.692													3	20					0	0	0	0	A	1080953	A	A	1080953	3	1	238	1	0	0	0	0	1	0	0	0	7279	1059	37	1	2146	1	HMHA1	19	1080953	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08		1080953	58048030	238	43531											
TRIP10	9322	broad.mit.edu	37	chr19	6746509	6746509	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgcccccagagcagcagcGaaaacggcttcaacagcagt	12	5	10	14	2	1	1	1	0	0	1	1	2	1	1	2	1	7	4	2	1	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:6746509G>A	uc002mfs.2	+	11	1265	c.1199G>A	c.(1198-1200)CGA>CAA	p.R400Q	TRIP10_uc010dux.1_Missense_Mutation_p.R344Q|TRIP10_uc002mfr.2_Missense_Mutation_p.R344Q|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Missense_Mutation_p.R163Q	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	400	Interaction with CDC42.|Interaction with PDE6G (By similarity).				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						GAGCAGCAGCGAAAACGGCTT	0.547													10	75					0	0	0	0	A	6746509	A	A	6746509	3	1	238	1	0	0	0	0	1	0	0	0	16621	1058	37	1	1069	1	TRIP10	19	6746509	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	5665556	6746509	52382474	239	43532											
ARHGEF18	23370	broad.mit.edu	37	chr19	7506611	7506611	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacagctgatgactctctGtcccttacatctccaaacac	11	10	5	15	0	2	3	0	2	2	1	5	3	3	3	2	0	3	1	2	0	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:7506611G>T	uc002mgi.2	+	2	868	c.615G>T	c.(613-615)CTG>CTT	p.L205L	ARHGEF18_uc010xjm.1_Silent_p.L47L|ARHGEF18_uc002mgh.2_Silent_p.L47L	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	205					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				ATGACTCTCTGTCCCTTACAT	0.458													27	96					2.12542e-12	2.97117e-12	1	0	T	7506611	T	T	7506611	2	4	238	1	0	0	0	0	0	0	0	1	901	1364	48	4		4	ARHGEF18	19	7506611	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	760102	7506611	51622372	240	43533											
FBN3	84467	broad.mit.edu	37	chr19	8196594	8196594	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcgcacgtgggtgtccaCgcacacgcggccatccgtgc	5	6	14	16	6	0	0	0	0	0	0	2	0	2	0	3	2	2	3	3	2	0	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr19:8196594C>G	uc002mjf.2	-	14	1855	c.1834G>C	c.(1834-1836)GTG>CTG	p.V612L		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	612	EGF-like 7; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TGGGTGTCCACGCACACGCGG	0.687													3	46					0	0	0	0	G	8196594	G	G	8196594	3	3	238	1	0	0	0	0	1	0	0	0	5736	536	19	3	6795	3	FBN3	19	8196594	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	689983	8196594	50932389	241	43534											
MUC16	94025	broad.mit.edu	37	chr19	9010683	9010683	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggaggatggagtccctgagGtcccaaggtccactgtggag	8	7	17	9	0	0	1	0	1	0	0	3	5	3	5	3	6	0	0	3	6	1	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:9010683G>C	uc002mkp.2	-	38	39182	c.38978C>G	c.(38977-38979)ACC>AGC	p.T12993S	MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12995	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTCCCTGAGGTCCCAAGGTC	0.512													6	26					0	0	0	0	C	9010683	C	C	9010683	3	2	238	1	0	0	0	0	1	0	0	0	10026	1261	44	4	4733	4	MUC16	19	9010683	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	814089	9010683	50118300	242	43535											
KEAP1	9817	broad.mit.edu	37	chr19	10602622	10602622	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccaccttgggcgcccggCagggcatcacctgcgtgggc	4	5	16	16	3	1	0	1	0	0	0	1	0	1	0	4	5	1	2	4	5	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:10602622C>A	uc002moq.1	-	3	1112	c.956G>T	c.(955-957)TGC>TTC	p.C319F	KEAP1_uc002mop.1_Missense_Mutation_p.C37F|KEAP1_uc002mor.1_Missense_Mutation_p.C319F	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	319					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GGGCGCCCGGCAGGGCATCAC	0.642													14	34					9.31168e-06	1.10645e-05	1	0	A	10602622	A	A	10602622	3	1	238	1	0	0	0	0	1	0	0	0	8180	710	25	4	934	4	KEAP1	19	10602622	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1591939	10602622	48526361	243	43536											
RGL3	57139	broad.mit.edu	37	chr19	11527319	11527319	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gttgaagctcagatcttgtaCcgctgtcttcttgatctcta	7	16	8	10	1	5	3	1	2	4	1	6	3	5	3	1	0	2	4	1	0	3	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:11527319C>T	uc002mrp.2	-	4	458	c.394G>A	c.(394-396)GTA>ATA	p.V132I	RGL3_uc002mrn.2_5'UTR|RGL3_uc002mrm.2_5'UTR|RGL3_uc002mro.2_Missense_Mutation_p.V132I|RGL3_uc002mrq.2_3'UTR	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	132	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						AGATCTTGTACCGCTGTCTTC	0.567													23	94					0	0	0	0	T	11527319	T	T	11527319	3	4	238	1	0	0	0	0	1	0	0	0	13343	507	18	4	1820	4	RGL3	19	11527319	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	924697	11527319	47601664	244	43537											
ZNF257	113835	broad.mit.edu	37	chr19	22271482	22271482	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actcaacataagagaattcaTactggagagaaaccctacaa	19	7	6	9	0	2	2	2	0	0	2	2	5	2	3	1	1	4	0	1	1	7	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:22271482T>A	uc010ecx.2	+	4	1099	c.930T>A	c.(928-930)CAT>CAA	p.H310Q	ZNF257_uc010ecy.2_Missense_Mutation_p.H278Q	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	310	C2H2-type 5; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGAGAATTCATACTGGAGAGA	0.408													4	52					0	0	0	0	A	22271482	A	A	22271482	3	1	238	1	0	0	0	0	1	0	0	0	17867	1403	49	5	944	5	ZNF257	19	22271482	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	10744163	22271482	36857501	245	43538											
ZNF99	7652	broad.mit.edu	37	chr19	22952031	22952031	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtttctgtagttctctaaCataacattcctatataaatt	13	17	4	7	0	2	0	0	0	2	0	4	0	3	0	1	1	2	3	1	1	7	10			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:22952031C>G	uc010xrh.1	-	2	162	c.162G>C	c.(160-162)ATG>ATC	p.M54I		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AGTTCTCTAACATAACATTCC	0.393													7	78					0	0	0	0	G	22952031	G	G	22952031	3	3	238	1	0	0	0	0	1	0	0	0	18271	478	17	4	2974	4	ZNF99	19	22952031	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	680549	22952031	36176952	246	43539											
SIRT2	22933	broad.mit.edu	37	chr19	39390156	39390156	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgactcacggtctggctcTgccatgggcgcggtgctgaa	5	8	14	14	4	3	1	1	1	2	0	3	2	3	1	2	4	2	2	2	4	1	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:39390156T>C	uc002ojt.1	-	1	206	c.6A>G	c.(4-6)GCA>GCG	p.A2A	SIRT2_uc002oju.1_5'UTR|SIRT2_uc010egj.1_5'UTR|SIRT2_uc002ojv.1_Silent_p.A2A|NFKBIB_uc010egk.1_5'Flank|NFKBIB_uc002ojw.2_5'Flank|NFKBIB_uc002ojx.2_5'Flank|NFKBIB_uc002ojy.2_5'Flank	NM_012237	NP_036369	Q8IXJ6	SIRT2_HUMAN	sirtuin 2 isoform 1	2					cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			GGTCTGGCTCTGCCATGGGCG	0.706													12	34					0	0	0	0	C	39390156	C	C	39390156	2	2	238	1	0	0	0	0	0	0	0	1	14403	1567	55	5		5	SIRT2	19	39390156	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	16438125	39390156	19738827	247	43540											
MEGF8	1954	broad.mit.edu	37	chr19	42860263	42860263	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgtgtgcatctgtgccgaggGcttcgggggccccgactgcg	3	9	17	12	4	1	0	0	0	1	0	2	2	1	0	3	3	3	2	3	3	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:42860263G>A	uc002otl.3	+	24	4855	c.4220G>A	c.(4219-4221)GGC>GAC	p.G1407D	MEGF8_uc002otm.3_Missense_Mutation_p.G1015D	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1474	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				TGTGCCGAGGGCTTCGGGGGC	0.672													9	13					0	0	0	0	A	42860263	A	A	42860263	3	1	238	1	0	0	0	0	1	0	0	0	9516	1203	42	4	4314	4	MEGF8	19	42860263	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3470107	42860263	16268720	248	43541											
PSG7	5676	broad.mit.edu	37	chr19	43439857	43439857	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttcccctcggaaactttTggtggctgggcttcaatcgt	5	14	10	12	2	1	0	1	0	0	0	5	1	3	1	3	4	1	2	3	4	2	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:43439857T>C	uc002ovl.3	-	2	231	c.129A>G	c.(127-129)CCA>CCG	p.P43P	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	43	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				CGGAAACTTTTGGTGGCTGGG	0.493													27	167					0	0	0	0	C	43439857	C	C	43439857	2	2	238	1	0	0	0	0	0	0	0	1	12722	1799	63	5		5	PSG7	19	43439857	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	579594	43439857	15689126	249	43542											
DHX34	9704	broad.mit.edu	37	chr19	47863303	47863303	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agacctcagtcaccattgacGggatccgcttcgtagtagat	10	10	10	11	3	2	3	2	1	0	2	4	4	3	4	3	1	0	3	3	1	2	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:47863303G>T	uc010xyn.1	+	5	1692	c.1351G>T	c.(1351-1353)GGG>TGG	p.G451W	DHX34_uc010elc.1_Missense_Mutation_p.G366W	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	451	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CACCATTGACGGGATCCGCTT	0.592													33	100					2.08457e-15	3.02937e-15	1	0	T	47863303	T	T	47863303	3	4	238	1	0	0	0	0	1	0	0	0	4529	1116	39	3	1365	3	DHX34	19	47863303	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	4423446	47863303	11265680	250	43543											
CRX	1406	broad.mit.edu	37	chr19	48337742	48337742	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggccccactattctgtcaaCgccttggccctaagtggccc	6	9	10	16	1	2	0	1	0	1	0	2	0	2	0	5	3	1	0	5	3	3	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:48337742C>T	uc002phq.3	+	2	246	c.42C>T	c.(40-42)AAC>AAT	p.N14N	CRX_uc010elm.1_Intron	NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	14					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		ATTCTGTCAACGCCTTGGCCC	0.587													16	50					0	0	0	0	T	48337742	T	T	48337742	2	4	238	1	0	0	0	0	0	0	0	1	3917	535	19	1		1	CRX	19	48337742	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	474439	48337742	10791241	251	43544											
ZNF114	163071	broad.mit.edu	37	chr19	48785741	48785741	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgctggaaaattctaggaaCttggcattcataggtaagga	14	11	11	5	0	2	0	1	0	1	0	2	3	2	3	0	5	2	3	0	5	6	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:48785741C>T	uc002pil.1	+	5	620	c.123C>T	c.(121-123)AAC>AAT	p.N41N	ZNF114_uc010elv.1_Silent_p.N41N|ZNF114_uc002pim.1_Silent_p.N41N|ZNF114_uc002pin.2_Silent_p.N7N	NM_153608	NP_705836	Q8NC26	ZN114_HUMAN	zinc finger protein 114	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		ATTCTAGGAACTTGGCATTCA	0.527													13	113					0	0	0	0	T	48785741	T	T	48785741	2	4	238	1	0	0	0	0	0	0	0	1	17783	564	20	4		4	ZNF114	19	48785741	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	447999	48785741	10343242	252	43545											
PPP1R15A	23645	broad.mit.edu	37	chr19	49377451	49377451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaggctttgggggcagctGagaaggatggagaagctgag	11	7	18	5	0	1	3	1	2	0	2	1	6	1	4	0	5	2	4	0	5	3	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:49377451G>A	uc002pky.3	+	2	1230	c.961G>A	c.(961-963)GAG>AAG	p.E321K		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	321	Glu-rich.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GGGGGCAGCTGAGAAGGATGG	0.612													14	60					0	0	0	0	A	49377451	A	A	49377451	3	1	238	1	0	0	0	0	1	0	0	0	12423	1291	45	2	963	2	PPP1R15A	19	49377451	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	591710	49377451	9751532	253	43546											
SYT3	84258	broad.mit.edu	37	chr19	51133412	51133412	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtctgctgggtgaggggtcGgggcagggctgggtacctgt	4	9	21	7	1	1	1	0	1	1	0	2	1	1	1	1	7	2	4	1	7	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:51133412G>A	uc002pst.2	-	3	1325	c.691C>T	c.(691-693)CGA>TGA	p.R231*	SYT3_uc002psv.2_Nonsense_Mutation_p.R231*|SYT3_uc010ycd.1_Nonsense_Mutation_p.R231*	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	231	Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		GTGAGGGGTCGGGGCAGGGCT	0.657													18	16					0	0	0	0	A	51133412	A	A	51133412	4	1	238	1	0	0	0	0	0	1	0	0	15541	1124	39	1	1105	1	SYT3	19	51133412	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1755961	51133412	7995571	254	43547											
ZNF615	284370	broad.mit.edu	37	chr19	52496489	52496489	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccagtatgagtttgctgatGtatactgagagtactcttca	10	15	9	7	0	2	3	1	3	1	1	3	4	3	3	1	0	3	5	1	0	4	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:52496489G>T	uc002pye.1	-	6	2132	c.1840C>A	c.(1840-1842)CAT>AAT	p.H614N	ZNF615_uc002pyf.1_Missense_Mutation_p.H625N|ZNF615_uc002pyg.1_Missense_Mutation_p.H506N|ZNF615_uc002pyh.1_Missense_Mutation_p.H625N|ZNF615_uc010epi.1_Missense_Mutation_p.H621N|ZNF615_uc010ydg.1_Missense_Mutation_p.H619N	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	614	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GTTTGCTGATGTATACTGAGA	0.413													13	92					1.5842e-08	2.06457e-08	1	0	T	52496489	T	T	52496489	3	4	238	1	0	0	0	0	1	0	0	0	18107	1377	48	4	359	4	ZNF615	19	52496489	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1363077	52496489	6632494	255	43548											
ZNF528	84436	broad.mit.edu	37	chr19	52919017	52919017	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaatgtcatgaatgtgacaaGgtcttcaatcaaattgcaca	16	11	7	7	0	4	2	3	2	1	0	4	2	4	2	0	1	1	1	0	1	5	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:52919017G>T	uc002pzh.2	+	7	1338	c.912G>T	c.(910-912)AAG>AAT	p.K304N	ZNF528_uc002pzi.2_Missense_Mutation_p.K71N	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	304	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		AATGTGACAAGGTCTTCAATC	0.383													11	61					3.86212e-05	4.45799e-05	1	0	T	52919017	T	T	52919017	3	4	238	1	0	0	0	0	1	0	0	0	18036	991	35	4	926	4	ZNF528	19	52919017	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	422528	52919017	6209966	256	43549											
NLRP12	91662	broad.mit.edu	37	chr19	54314216	54314216	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcttcccgtccgcccagtCcagcatcaccttgtgtgcca	6	9	9	17	2	1	0	1	0	0	0	4	1	4	0	6	0	3	2	6	0	0	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:54314216C>A	uc002qch.3	-	3	917	c.697G>T	c.(697-699)GAC>TAC	p.D233Y	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.D233Y|NLRP12_uc002qcj.3_Missense_Mutation_p.D233Y|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.D233Y	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	233	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TCCGCCCAGTCCAGCATCACC	0.582													15	55					1.3612e-06	1.64649e-06	1	0	A	54314216	A	A	54314216	3	1	238	1	0	0	0	0	1	0	0	0	10528	855	30	2	2616	2	NLRP12	19	54314216	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1395199	54314216	4814767	257	43550											
NLRP12	91662	broad.mit.edu	37	chr19	54314237	54314237	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcatcaccttgtgtgccaGcatggacttgcctatccctg	7	11	9	14	0	1	0	1	0	0	0	2	1	2	1	4	1	4	2	4	1	1	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:54314237G>C	uc002qch.3	-	3	896	c.676C>G	c.(676-678)CTG>GTG	p.L226V	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.L226V|NLRP12_uc002qcj.3_Missense_Mutation_p.L226V|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.L226V	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	226	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TTGTGTGCCAGCATGGACTTG	0.582													16	68					0	0	0	0	C	54314237	C	C	54314237	3	2	238	1	0	0	0	0	1	0	0	0	10528	962	34	4	2637	4	NLRP12	19	54314237	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	21	54314237	4814746	258	43551											
PRKCG	5582	broad.mit.edu	37	chr19	54403990	54403990	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttctgcgggaccccggactAcatagccccggaggtaaccc	8	6	11	16	3	1	0	0	0	1	0	1	3	1	3	5	4	4	1	5	4	3	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:54403990A>G	uc002qcq.1	+	14	1844	c.1562A>G	c.(1561-1563)TAC>TGC	p.Y521C	PRKCG_uc010yeg.1_Missense_Mutation_p.Y521C|PRKCG_uc010yeh.1_Missense_Mutation_p.Y408C	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	521	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding	p.Y521N(1)		lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACCCCGGACTACATAGCCCCG	0.577													68	265					0	0	0	0	G	54403990	G	G	54403990	3	3	238	1	0	0	0	0	1	0	0	0	12574	391	14	5	1616	5	PRKCG	19	54403990	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	89753	54403990	4724993	259	43552											
TTYH1	57348	broad.mit.edu	37	chr19	54932552	54932552	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaccacacactcagcaccaTtgaccacctggtgaggggcc	11	5	9	16	0	1	2	1	2	0	0	1	2	1	2	5	3	2	1	5	3	1	1	rs141084064	byFrequency	TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr19:54932552T>C	uc002qfq.2	+	3	499	c.407T>C	c.(406-408)ATT>ACT	p.I136T	TTYH1_uc010yey.1_Missense_Mutation_p.I185T|TTYH1_uc002qfr.2_Missense_Mutation_p.I136T|TTYH1_uc002qft.2_Missense_Mutation_p.I136T|TTYH1_uc002qfu.1_Missense_Mutation_p.I51T	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	136	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		CTCAGCACCATTGACCACCTG	0.597													6	73					0	0	0	0	C	54932552	C	C	54932552	3	2	238	1	0	0	0	0	1	0	0	0	16807	1493	52	5	417	5	TTYH1	19	54932552	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	528562	54932552	4196431	260	43553											
GP6	51206	broad.mit.edu	37	chr19	55538970	55538970	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccacaagctccagggggtCgctgggggctgaccacaggt	8	5	16	12	1	0	1	0	1	0	0	2	2	1	1	3	5	1	3	3	5	1	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr19:55538970C>A	uc002qik.2	-	4	614	c.586G>T	c.(586-588)GAC>TAC	p.D196Y	GP6_uc002qil.2_Missense_Mutation_p.D196Y|GP6_uc010esq.2_Missense_Mutation_p.D196Y|RDH13_uc010esr.1_RNA	NM_016363	NP_057447	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet) isoform 2	196	Ig-like C2-type 2.|Extracellular (Potential).				enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		TCCAGGGGGTCGCTGGGGGCT	0.587													7	98					1.06961e-07	1.35888e-07	1	0	A	55538970	A	A	55538970	3	1	238	1	0	0	0	0	1	0	0	0	6622	884	31	3	1296	3	GP6	19	55538970	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	606418	55538970	3590013	261	43554											
NLRP8	126205	broad.mit.edu	37	chr19	56485092	56485092	+	Frame_Shift_Del	DEL	C	-	-																															caggcagagtaagatgctgaCccacctgagcttggcagaaa																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr19:56485092delC	uc002qmh.2	+	7	2680	c.2609delC	c.(2608-2610)ACCfs	p.T870fs	NLRP8_uc010etg.2_Frame_Shift_Del_p.T851fs	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	870	LRR 4.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AAGATGCTGACCCACCTGAGC	0.507													---	---	---								-	56485092	-	-	56485092	7	5	238	1	0	1	0	1	0	0	0	0	10537	507	18	0	2635	0	NLRP8	19	56485092	Frame_Shift_Del	DEL	C	TCGA-CV-7248-01A-11D-2012-08	946122	56485092	2643891	262	43555											
CSNK2A1	1457	broad.mit.edu	37	chr20	476380	476380	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacctttctgtgctcatgatCaatcatgacattatggggct	9	15	8	9	0	4	2	3	2	1	0	4	2	4	2	1	2	2	2	1	2	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr20:476380C>G	uc002wdw.1	-	8	886	c.493G>C	c.(493-495)GAT>CAT	p.D165H	CSNK2A1_uc002wdx.1_Missense_Mutation_p.D165H|CSNK2A1_uc002wdy.1_Missense_Mutation_p.D29H	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	165	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			TGCTCATGATCAATCATGACA	0.378													11	72					0	0	0	0	G	476380	G	G	476380	3	3	238	1	0	0	0	0	1	0	0	0	3974	826	29	2	710	2	CSNK2A1	20	476380	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08		476380	62549140	263	43556											
XRN2	22803	broad.mit.edu	37	chr20	21346226	21346226	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcagaaagccagcagcagtActgaaacctagtgactggga	14	6	12	9	0	1	3	1	2	0	1	1	4	1	4	2	1	5	3	2	1	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr20:21346226A>T	uc002wsf.1	+	26	2435	c.2340A>T	c.(2338-2340)GTA>GTT	p.V780V	XRN2_uc002wsg.1_Silent_p.V704V|XRN2_uc010zsk.1_Silent_p.V726V	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	780					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						CAGCAGCAGTACTGAAACCTA	0.443													19	68					0	0	0	0	T	21346226	T	T	21346226	2	4	238	1	0	0	0	0	0	0	0	1	17528	378	14	5		5	XRN2	20	21346226	Silent	SNP	A	TCGA-CV-7248-01A-11D-2012-08	20869846	21346226	41679294	264	43557											
TOX2	84969	broad.mit.edu	37	chr20	42695453	42695453	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccaccagcagcggggactgGgacagcagctaccccagtgg	9	3	14	15	1	0	0	0	0	0	0	0	2	0	2	4	4	5	3	4	4	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr20:42695453G>T	uc002xlf.3	+	7	1403	c.1386G>T	c.(1384-1386)TGG>TGT	p.W462C	TOX2_uc010ggo.2_Missense_Mutation_p.W480C|TOX2_uc002xle.3_Missense_Mutation_p.W438C|TOX2_uc010ggp.2_Missense_Mutation_p.W438C|TOX2_uc002xlg.2_Missense_Mutation_p.W279C|TOX2_uc010zwk.1_Missense_Mutation_p.W358C	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GCGGGGACTGGGACAGCAGCT	0.637													38	148					4.67007e-22	7.09288e-22	1	0	T	42695453	T	T	42695453	3	4	238	1	0	0	0	0	1	0	0	0	16445	1241	43	4	1600	4	TOX2	20	42695453	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	21349227	42695453	20330067	265	43558											
FITM2	128486	broad.mit.edu	37	chr20	42935681	42935681	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctgaccccctccagggctgGggactggtagcagctgcccg	5	7	14	15	1	1	1	0	1	1	0	2	2	2	2	4	4	3	4	4	4	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr20:42935681G>A	uc002xlr.1	-	2	474	c.373C>T	c.(373-375)CCA>TCA	p.P125S		NM_001080472	NP_001073941	Q8N6M3	FITM2_HUMAN	fat storage-inducing transmembrane protein 2	125	Extracellular (Potential).				cellular triglyceride homeostasis|lipid particle organization|positive regulation of sequestering of triglyceride|regulation of triglyceride biosynthetic process	integral to endoplasmic reticulum membrane				skin(2)	2						TCCAGGGCTGGGGACTGGTAG	0.597													9	56					0	0	0	0	A	42935681	A	A	42935681	3	1	238	1	0	0	0	0	1	0	0	0	5931	1232	43	4	419	4	FITM2	20	42935681	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	240228	42935681	20089839	266	43559											
SYNJ1	8867	broad.mit.edu	37	chr21	34029187	34029187	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcttcaacttcaaatatatCtatatcaatcagggcaacga	16	11	5	9	1	5	0	4	0	1	0	5	1	5	0	0	1	3	2	0	1	8	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr21:34029187C>T	uc002yqh.2	-	21	2722	c.2722G>A	c.(2722-2724)GAT>AAT	p.D908N	SYNJ1_uc011ads.1_Missense_Mutation_p.D864N|SYNJ1_uc002yqf.2_Missense_Mutation_p.D869N|SYNJ1_uc002yqg.2_Missense_Mutation_p.D864N|SYNJ1_uc002yqi.2_Missense_Mutation_p.D908N	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	869	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						TCAAATATATCTATATCAATC	0.343													6	34					0	0	0	0	T	34029187	T	T	34029187	3	4	238	1	0	0	0	0	1	0	0	0	15518	913	32	2	2189	2	SYNJ1	21	34029187	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08		34029187	14100708	267	43560											
PCNT	5116	broad.mit.edu	37	chr21	47773909	47773909	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcccttcaggttgtcctGtgtgggtttagaagagaaac	8	15	11	7	0	1	2	1	0	0	2	3	3	3	2	2	2	1	2	2	2	3	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr21:47773909G>A	uc002zji.3	+	11	1795	c.1688G>A	c.(1687-1689)TGT>TAT	p.C563Y	PCNT_uc002zjj.2_Missense_Mutation_p.C445Y	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	563	Glu-rich.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AGGTTGTCCTGTGTGGGTTTA	0.493													10	22					0	0	0	0	A	47773909	A	A	47773909	3	1	238	1	0	0	0	0	1	0	0	0	11644	1377	48	4	1730	4	PCNT	21	47773909	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	13744722	47773909	355986	268	43561											
DIP2A	23181	broad.mit.edu	37	chr21	47931456	47931456	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccttgcagcgctggggcaCaacacagcccaaatccccct	10	5	8	18	1	0	0	0	0	0	0	1	0	1	0	4	2	4	3	4	2	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr21:47931456C>T	uc002zjo.2	+	8	1214	c.1031C>T	c.(1030-1032)ACA>ATA	p.T344I	DIP2A_uc011afy.1_Missense_Mutation_p.T280I|DIP2A_uc011afz.1_Missense_Mutation_p.T340I|DIP2A_uc002zjl.2_Missense_Mutation_p.T344I|DIP2A_uc002zjm.2_Missense_Mutation_p.T344I|DIP2A_uc010gql.2_Missense_Mutation_p.T301I|DIP2A_uc002zjn.2_Missense_Mutation_p.T344I|DIP2A_uc002zjp.1_Missense_Mutation_p.T89I	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	344					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CGCTGGGGCACAACACAGCCC	0.582													6	26					0	0	0	0	T	47931456	T	T	47931456	3	4	238	1	0	0	0	0	1	0	0	0	4549	478	17	4	1061	4	DIP2A	21	47931456	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	157547	47931456	198439	269	43562											
ZNF280A	129025	broad.mit.edu	37	chr22	22868532	22868532	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccggctttttaaatgtttGatggtccttggttttgtgct	4	20	10	7	1	0	1	0	1	0	0	2	1	2	1	2	3	1	4	2	3	2	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr22:22868532G>C	uc002zwe.2	-	2	1676	c.1423C>G	c.(1423-1425)CAA>GAA	p.Q475E	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	475					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TTAAATGTTTGATGGTCCTTG	0.458													27	83					0	0	0	0	C	22868532	C	C	22868532	3	2	238	1	0	0	0	0	1	0	0	0	17881	1299	45	2	209	2	ZNF280A	22	22868532	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08		22868532	28436034	270	43563											
SLC5A1	6523	broad.mit.edu	37	chr22	32479071	32479071	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctgcttagggggcctggcGgcggtgatttacacggacac	6	8	16	11	3	0	1	0	1	0	0	0	2	0	2	2	6	2	1	2	6	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr22:32479071G>A	uc003amc.2	+	7	826	c.594G>A	c.(592-594)GCG>GCA	p.A198A	SLC5A1_uc011alz.1_Silent_p.A71A	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	198	Helical; (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						GGGGCCTGGCGGCGGTGATTT	0.572													7	45					0	0	0	0	A	32479071	A	A	32479071	2	1	238	1	0	0	0	0	0	0	0	1	14725	1103	39	1		1	SLC5A1	22	32479071	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	9610539	32479071	18825495	271	43564											
RFPL2	10739	broad.mit.edu	37	chr22	32587270	32587270	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtctgatgcgcccacttCggacgctcctgaggtcgtca	5	11	11	14	4	3	2	1	2	2	0	6	3	4	3	2	2	1	1	2	2	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr22:32587270C>A	uc003amg.3	-	5	1562	c.626G>T	c.(625-627)CGA>CTA	p.R209L	RFPL2_uc003ame.3_Missense_Mutation_p.R148L|RFPL2_uc003amf.3_Missense_Mutation_p.R119L|RFPL2_uc003amh.3_Missense_Mutation_p.R119L	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	209	B30.2/SPRY.						zinc ion binding			skin(1)	1						GCGCCCACTTCGGACGCTCCT	0.532													24	94					2.21704e-12	3.0674e-12	1	0	A	32587270	A	A	32587270	3	1	238	1	0	0	0	0	1	0	0	0	13319	884	31	3	514	3	RFPL2	22	32587270	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	108199	32587270	18717296	272	43565											
CELSR1	9620	broad.mit.edu	37	chr22	46790128	46790128	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtccacagacggggttccCccaccagcctctggggcacg	6	5	14	16	2	1	1	0	0	1	1	3	1	3	1	5	5	1	2	5	5	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chr22:46790128C>A	uc003bhw.1	-	14	5875	c.5875G>T	c.(5875-5877)GGG>TGG	p.G1959W	CELSR1_uc011arc.1_Missense_Mutation_p.G280W	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1959	Extracellular (Potential).|EGF-like 7; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ACGGGGTTCCCCCACCAGCCT	0.572													12	35					7.03913e-09	9.29349e-09	1	0	A	46790128	A	A	46790128	3	1	238	1	0	0	0	0	1	0	0	0	3236	623	22	4	3257	4	CELSR1	22	46790128	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	14202858	46790128	4514438	273	43566											
PIM3	415116	broad.mit.edu	37	chr22	50354606	50354606	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtcgcccgcgatgctgctctCcaagttcggctccctggcgc	3	9	12	17	5	1	0	0	0	1	0	5	1	2	0	3	2	2	4	3	2	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	6075d925-abdf-40d0-8705-47d971008ae3	g.chr22:50354606C>G	uc003bjb.2	+	1	464	c.11C>G	c.(10-12)TCC>TGC	p.S4C	PIM3_uc011arj.1_5'Flank	NM_001001852	NP_001001852	Q86V86	PIM3_HUMAN	serine/threonine protein kinase pim-3	4					cell cycle|negative regulation of apoptosis|regulation of mitotic cell cycle		ATP binding|protein binding|protein serine/threonine kinase activity				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.196)|LUAD - Lung adenocarcinoma(64;0.247)		ATGCTGCTCTCCAAGTTCGGC	0.682													2	4					0	0	0	0	G	50354606	G	G	50354606	3	3	238	1	0	0	0	0	1	0	0	0	11984	855	30	2	13	2	PIM3	22	50354606	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3564478	50354606	949960	274	43567											
WWC3	55841	broad.mit.edu	37	chrX	10096607	10096607	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctgcaggatgcggtgaCggtgctcctggccagaacca	7	8	13	13	2	0	2	0	1	0	1	2	3	2	3	4	4	4	2	4	4	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:10096607C>T	uc004csx.3	+	17	2489	c.2291C>T	c.(2290-2292)ACG>ATG	p.T764M	WWC3_uc010nds.2_Missense_Mutation_p.T428M|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	764	Potential.									ovary(4)	4						GATGCGGTGACGGTGCTCCTG	0.667													4	24					0	0	0	0	T	10096607	T	T	10096607	3	4	238	1	0	0	0	0	1	0	0	0	17481	536	19	1	2353	1	WWC3	23	10096607	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08		10096607	145173953	275	43568											
PHKA2	5256	broad.mit.edu	37	chrX	18919705	18919705	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggtagggctggatgtggaGgagtggatagggcgcactgg	8	8	21	4	1	0	0	0	0	0	0	0	4	0	4	0	8	0	3	0	8	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:18919705G>T	uc004cyv.3	-	27	3355	c.2925C>A	c.(2923-2925)TCC>TCA	p.S975S	PHKA2_uc004cyu.3_Silent_p.S273S|PHKA2_uc010nfe.1_Silent_p.S25S|PHKA2_uc010nff.1_Intron	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	975					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					TGGATGTGGAGGAGTGGATAG	0.557													11	41					4.68919e-08	5.97613e-08	1	0	T	18919705	T	T	18919705	2	4	238	1	0	0	0	0	0	0	0	1	11899	987	35	4		4	PHKA2	23	18919705	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	8823098	18919705	136350855	276	43569											
PHEX	5251	broad.mit.edu	37	chrX	22129609	22129609	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	attgccaactatttggtgtgGagaatggtttattccagaat	11	15	10	5	0	0	2	0	0	0	2	1	3	1	2	2	3	2	1	2	3	5	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:22129609G>C	uc004dah.2	+	10	1307	c.1104G>C	c.(1102-1104)TGG>TGC	p.W368C	PHEX_uc011mjr.1_Missense_Mutation_p.W368C|PHEX_uc011mjs.1_Missense_Mutation_p.W271C	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	368	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						ATTTGGTGTGGAGAATGGTTT	0.398													42	201					0	0	0	0	C	22129609	C	C	22129609	3	2	238	1	0	0	0	0	1	0	0	0	11874	1183	41	2	1142	2	PHEX	23	22129609	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3209904	22129609	133140951	277	43570											
DCAF8L2	347442	broad.mit.edu	37	chrX	27765882	27765882	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgattccactctggccatGtgtgcccgtgatgggcaggt	5	11	15	10	1	1	2	0	2	1	0	2	2	2	2	3	4	1	1	3	4	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:27765882G>T	uc011mjy.1	+	1	957	c.870G>T	c.(868-870)ATG>ATT	p.M290I		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						CTCTGGCCATGTGTGCCCGTG	0.502													8	23					0.00307968	0.00335361	1	0	T	27765882	T	T	27765882	3	4	238	1	0	0	0	0	1	0	0	0	4295	1377	48	4	872	4	DCAF8L2	23	27765882	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	5636273	27765882	127504678	278	43571											
NR0B1	190	broad.mit.edu	37	chrX	30327463	30327463	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggatgctgccctgccactgGtggttctcgcccgccatggc	4	9	13	15	2	1	0	0	0	1	0	2	1	1	1	4	4	3	2	4	4	0	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:30327463G>A	uc004dcf.3	-	1	33	c.18C>T	c.(16-18)CAC>CAT	p.H6H		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	6	4 X 67 AA tandem repeats.|1.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	CCTGCCACTGGTGGTTCTCGC	0.662													6	14					0	0	0	0	A	30327463	A	A	30327463	2	1	238	1	0	0	0	0	0	0	0	1	10667	1252	44	4		4	NR0B1	23	30327463	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	2561581	30327463	124943097	279	43572											
FAM47B	170062	broad.mit.edu	37	chrX	34962805	34962805	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaagggatggacttacgaCtctgttaagactcctattca	13	11	9	8	1	2	2	1	0	1	2	3	5	3	4	1	2	1	1	1	2	5	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:34962805C>G	uc004ddi.1	+	1	1875	c.1857C>G	c.(1855-1857)GAC>GAG	p.D619E		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	619										ovary(3)|breast(1)	4						GGACTTACGACTCTGTTAAGA	0.403													29	162					0	0	0	0	G	34962805	G	G	34962805	3	3	238	1	0	0	0	0	1	0	0	0	5602	564	20	4	1859	4	FAM47B	23	34962805	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	4635342	34962805	120307755	280	43573											
CXorf22	170063	broad.mit.edu	37	chrX	35990013	35990013	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggacttaaatcagaaccaTccactccacaagaaaaacat	20	6	4	11	0	1	2	1	0	0	2	3	3	3	3	3	1	2	0	3	1	7	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:35990013T>C	uc004ddj.2	+	13	2244	c.2185T>C	c.(2185-2187)TCC>CCC	p.S729P	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	729										large_intestine(1)|lung(1)|ovary(1)	3						ATCAGAACCATCCACTCCACA	0.323													3	12					0	0	0	0	C	35990013	C	C	35990013	3	2	238	1	0	0	0	0	1	0	0	0	4119	1435	50	5	2235	5	CXorf22	23	35990013	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	1027208	35990013	119280547	281	43574											
FAM47C	442444	broad.mit.edu	37	chrX	37026701	37026701	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatacgcttgtttgtcgccGtgacgagtttttactcccca	7	14	9	11	4	0	2	0	1	0	1	2	3	1	2	3	0	2	3	3	0	2	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:37026701G>T	uc004ddl.1	+	1	232	c.218G>T	c.(217-219)CGT>CTT	p.R73L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	73										ovary(3)	3						GTTTGTCGCCGTGACGAGTTT	0.527													23	80					1.22574e-08	1.60779e-08	1	0	T	37026701	T	T	37026701	3	4	238	1	0	0	0	0	1	0	0	0	5603	1145	40	3	220	3	FAM47C	23	37026701	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1036688	37026701	118243859	282	43575											
USP9X	8239	broad.mit.edu	37	chrX	41031206	41031206	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtacttatgaaacttatgcCgccaggtaagaatttttaaa	15	13	7	6	1	0	2	0	1	0	1	0	2	0	2	2	1	3	2	2	1	8	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:41031206C>G	uc004dfb.2	+	21	3776	c.3143C>G	c.(3142-3144)CCG>CGG	p.P1048R	USP9X_uc004dfc.2_Missense_Mutation_p.P1048R	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1048					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						AAACTTATGCCGCCAGGTAAG	0.388													8	68					0	0	0	0	G	41031206	G	G	41031206	3	3	238	1	0	0	0	0	1	0	0	0	17158	652	23	3	3221	3	USP9X	23	41031206	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	4004505	41031206	114239354	283	43576											
ZNF157	7712	broad.mit.edu	37	chrX	47272115	47272115	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atcagaaaactcacacagggGagaggccctttgaatgtaat	15	8	10	8	0	2	3	2	1	0	2	2	4	2	3	1	3	1	1	1	3	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:47272115G>C	uc004dhr.1	+	4	712	c.643G>C	c.(643-645)GAG>CAG	p.E215Q		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	215					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TCACACAGGGGAGAGGCCCTT	0.443													13	38					0	0	0	0	C	47272115	C	C	47272115	3	2	238	1	0	0	0	0	1	0	0	0	17804	1175	41	2	657	2	ZNF157	23	47272115	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	6240909	47272115	107998445	284	43577											
UXT	8409	broad.mit.edu	37	chrX	47516687	47516687	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catagatgcgtgaagtatctGggctgaggaaagagaggtta	13	9	15	4	1	1	4	0	2	1	2	1	6	1	5	0	3	1	3	0	3	5	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:47516687G>A	uc004din.2	-	5	307	c.251C>T	c.(250-252)CCA>CTA	p.P84L	UXT_uc004dim.2_Missense_Mutation_p.P96L|LOC100133957_uc011mls.1_5'Flank|LOC100133957_uc011mlt.1_5'Flank	NM_004182	NP_004173	Q9UBK9	UXT_HUMAN	ubiquitously-expressed transcript isoform 2	84					centrosome organization|mitochondrion transport along microtubule|protein folding	centrosome|nucleus|prefoldin complex	beta-tubulin binding|microtubule binding|unfolded protein binding				0						TGAAGTATCTGGGCTGAGGAA	0.333													6	14					0	0	0	0	A	47516687	A	A	47516687	3	1	238	1	0	0	0	0	1	0	0	0	17178	1348	47	4	234	4	UXT	23	47516687	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	244572	47516687	107753873	285	43578											
ZNF182	7569	broad.mit.edu	37	chrX	47836067	47836067	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacctctctgatgcagcatGaggtaggacttctgagagaa	11	10	12	8	0	2	5	0	4	2	1	3	7	2	6	1	2	2	3	1	2	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:47836067G>C	uc004dir.2	-	7	1765	c.1419C>G	c.(1417-1419)CTC>CTG	p.L473L	ZNF182_uc004dis.2_Silent_p.L454L|ZNF182_uc004dit.2_Silent_p.L473L|ZNF182_uc011mlu.1_Silent_p.L453L	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	473	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						GATGCAGCATGAGGTAGGACT	0.393													9	59					0	0	0	0	C	47836067	C	C	47836067	2	2	238	1	0	0	0	0	0	0	0	1	17817	1277	45	2		2	ZNF182	23	47836067	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	319380	47836067	107434493	286	43579											
TBC1D25	4943	broad.mit.edu	37	chrX	48418232	48418232	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaggatggcccacatctacgGgcgctgcacgacctgctcac	8	6	12	15	3	2	0	1	0	1	0	2	3	2	1	2	3	3	3	2	3	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:48418232G>A	uc004dka.1	+	6	1047	c.936G>A	c.(934-936)CGG>CGA	p.R312R	TBC1D25_uc011mly.1_Silent_p.R254R|TBC1D25_uc004dkb.1_Silent_p.R58R|TBC1D25_uc011mlz.1_Silent_p.R58R|TBC1D25_uc011mma.1_Silent_p.R58R|TBC1D25_uc004dkc.1_Silent_p.R58R|TBC1D25_uc011mmb.1_Silent_p.R316R|TBC1D25_uc011mmc.1_Silent_p.R58R|TBC1D25_uc011mmd.1_Silent_p.R58R	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	312	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(1)	1						CACATCTACGGGCGCTGCACG	0.622													9	37					0	0	0	0	A	48418232	A	A	48418232	2	1	238	1	0	0	0	0	0	0	0	1	15681	1219	43	4		4	TBC1D25	23	48418232	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	582165	48418232	106852328	287	43580											
HDAC6	10013	broad.mit.edu	37	chrX	48681334	48681334	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttccagaggtagaagacaGagaaggaccctccagttcta	13	7	12	9	0	1	4	0	0	1	4	3	6	3	5	3	3	0	3	3	3	4	4			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:48681334G>T	uc011mmi.1	+	25	2620	c.2525G>T	c.(2524-2526)AGA>ATA	p.R842I	HDAC6_uc004dks.1_Missense_Mutation_p.R842I|HDAC6_uc010nig.1_Missense_Mutation_p.R690I|HDAC6_uc004dkt.1_Missense_Mutation_p.R842I|HDAC6_uc011mmk.1_Missense_Mutation_p.R823I|HDAC6_uc004dkv.1_Missense_Mutation_p.R490I|HDAC6_uc004dkw.1_Missense_Mutation_p.R490I|HDAC6_uc004dkx.1_Missense_Mutation_p.R205I	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	842					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	GTAGAAGACAGAGAAGGACCC	0.562													5	48					1.23904e-05	1.45515e-05	1	0	T	48681334	T	T	48681334	3	4	238	1	0	0	0	0	1	0	0	0	7050	942	33	2	2619	2	HDAC6	23	48681334	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	263102	48681334	106589226	288	43581											
MAGIX	79917	broad.mit.edu	37	chrX	49021378	49021378	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggggacactccgctggccGtgcgcgggctgctgaaggat	5	7	17	12	4	0	1	0	1	0	0	1	3	1	3	2	5	2	3	2	5	1	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:49021378G>T	uc010nin.1	+	4	504	c.457G>T	c.(457-459)GTG>TTG	p.V153L	MAGIX_uc010nio.1_Intron|MAGIX_uc004dmt.2_Intron|MAGIX_uc004dmu.2_Missense_Mutation_p.V94L|MAGIX_uc004dmw.2_Missense_Mutation_p.V86L	NM_024859	NP_079135	Q9H6Y5	MAGIX_HUMAN	MAGI family member, X-linked isoform a	153	PDZ.										0						TCCGCTGGCCGTGCGCGGGCT	0.632													27	96					6.32553e-13	8.90423e-13	1	0	T	49021378	T	T	49021378	3	4	238	1	0	0	0	0	1	0	0	0	9246	1145	40	3	511	3	MAGIX	23	49021378	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	340044	49021378	106249182	289	43582											
CACNA1F	778	broad.mit.edu	37	chrX	49065125	49065125	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggagccccggcgagctgagGgctgggagaccatcgtggcc	6	4	18	13	4	0	2	0	1	0	1	1	5	0	3	4	5	2	2	4	5	0	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:49065125G>T	uc004dnb.2	-	43	5068	c.5006C>A	c.(5005-5007)CCC>CAC	p.P1669H	CACNA1F_uc010nip.2_Missense_Mutation_p.P1658H	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1669	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GCGAGCTGAGGGCTGGGAGAC	0.562													12	65					4.36969e-10	5.88452e-10	1	0	T	49065125	T	T	49065125	3	4	238	1	0	0	0	0	1	0	0	0	2555	1232	43	4	951	4	CACNA1F	23	49065125	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	43747	49065125	106205435	290	43583											
AKAP4	8852	broad.mit.edu	37	chrX	49961630	49961630	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttaagttgccttctgagctgGaactagcagcatcctatgga	10	12	10	9	0	1	1	0	1	1	0	2	3	2	3	2	2	5	4	2	2	4	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:49961630G>C	uc004dow.1	-	4	312	c.188C>G	c.(187-189)TCC>TGC	p.S63C	AKAP4_uc004dov.1_Missense_Mutation_p.S54C|AKAP4_uc010njp.1_5'UTR|AKAP4_uc004dou.1_Missense_Mutation_p.S54C	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	63					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					TTCTGAGCTGGAACTAGCAGC	0.418													15	63					0	0	0	0	C	49961630	C	C	49961630	3	2	238	1	0	0	0	0	1	0	0	0	453	1174	41	2	2388	2	AKAP4	23	49961630	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	896505	49961630	105308930	291	43584											
SHROOM4	57477	broad.mit.edu	37	chrX	50376870	50376870	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgctgccacaagtggctGtgaattatgctctggagacc	8	10	13	10	0	1	2	0	1	1	1	1	3	1	2	2	3	3	4	2	3	3	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:50376870G>C	uc004dpe.2	-	4	2229	c.2203C>G	c.(2203-2205)CAG>GAG	p.Q735E	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.Q619E	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	735					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					ACAAGTGGCTGTGAATTATGC	0.542													14	54					0	0	0	0	C	50376870	C	C	50376870	3	2	238	1	0	0	0	0	1	0	0	0	14361	1386	48	4	2302	4	SHROOM4	23	50376870	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	415240	50376870	104893690	292	43585											
GNL3L	54552	broad.mit.edu	37	chrX	54577458	54577458	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcagccgcgcatgcagcGtgggagctgttcctggaatt	7	8	15	11	4	0	0	0	0	0	0	1	2	1	2	2	2	5	5	2	2	1	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:54577458G>T	uc004dth.1	+	10	977	c.838G>T	c.(838-840)GTG>TTG	p.V280L	GNL3L_uc004dti.2_RNA	NM_019067	NP_061940	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3	280	G.				ribosome biogenesis	nucleolus	GTP binding			ovary(1)	1						CGCATGCAGCGTGGGAGCTGT	0.557													7	44					5.18039e-06	6.19195e-06	1	0	T	54577458	T	T	54577458	3	4	238	1	0	0	0	0	1	0	0	0	6575	1145	40	3	872	3	GNL3L	23	54577458	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	4200588	54577458	100693102	293	43586											
USP51	158880	broad.mit.edu	37	chrX	55513447	55513447	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttattctcattgggcacAcaatctgttggtggctggcc	7	14	10	10	0	2	0	1	0	2	0	3	0	2	0	1	4	1	3	1	4	3	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:55513447A>T	uc004dun.1	-	2	2005	c.1926T>A	c.(1924-1926)TGT>TGA	p.C642*	USP51_uc011moo.1_Nonsense_Mutation_p.C346*	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	642					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						CATTGGGCACACAATCTGTTG	0.443													3	32					0	0	0	0	T	55513447	T	T	55513447	4	4	238	1	0	0	0	0	0	1	0	0	17151	157	6	5	213	5	USP51	23	55513447	Nonsense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	935989	55513447	99757113	294	43587											
RRAGB	10325	broad.mit.edu	37	chrX	55784705	55784705	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctactctgatcaacatcCgcaatgccaggaaacacttt	13	9	6	13	1	2	1	1	1	1	0	3	2	3	2	2	1	5	2	2	1	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:55784705C>A	uc004dup.2	+	11	1705	c.1054C>A	c.(1054-1056)CGC>AGC	p.R352S	RRAGB_uc004duq.2_Missense_Mutation_p.R324S	NM_016656	NP_057740	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B long isoform	352					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding				0						GATCAACATCCGCAATGCCAG	0.443													9	38					0.000442599	0.00049259	1	0	A	55784705	A	A	55784705	3	1	238	1	0	0	0	0	1	0	0	0	13738	652	23	3	1096	3	RRAGB	23	55784705	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	271258	55784705	99485855	295	43588											
HEPH	9843	broad.mit.edu	37	chrX	65486459	65486459	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgacagagaaagctacgacGcaataggaggtccatcctgg	13	6	12	10	3	0	1	0	0	0	1	3	5	2	2	2	3	2	2	2	3	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:65486459G>T	uc011moz.1	+	21	3491	c.3431G>T	c.(3430-3432)CGC>CTC	p.R1144L	HEPH_uc004dwn.2_Missense_Mutation_p.R1143L|HEPH_uc004dwo.2_Missense_Mutation_p.R874L|HEPH_uc010nkr.2_Missense_Mutation_p.R952L|HEPH_uc011mpa.1_Missense_Mutation_p.R1144L	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1141	Cytoplasmic (Potential).				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						AAGCTACGACGCAATAGGAGG	0.493													16	46					4.14922e-12	5.7211e-12	1	0	T	65486459	T	T	65486459	3	4	238	1	0	0	0	0	1	0	0	0	7093	1087	38	3	3666	3	HEPH	23	65486459	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	9701754	65486459	89784101	296	43589											
STARD8	9754	broad.mit.edu	37	chrX	67942409	67942409	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagagaatatccaggaccTgctgcgtgatgctgctgagc	10	8	14	9	1	0	3	0	2	0	1	1	6	1	5	2	2	5	3	2	2	3	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:67942409T>C	uc004dxa.2	+	11	2852	c.2480T>C	c.(2479-2481)CTG>CCG	p.L827P	STARD8_uc004dxb.2_Missense_Mutation_p.L907P|STARD8_uc004dxc.3_Missense_Mutation_p.L827P	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	827	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						ATCCAGGACCTGCTGCGTGAT	0.647													9	39					0	0	0	0	C	67942409	C	C	67942409	3	2	238	1	0	0	0	0	1	0	0	0	15329	1580	55	5	2766	5	STARD8	23	67942409	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	2455950	67942409	87328151	297	43590											
SNX12	29934	broad.mit.edu	37	chrX	70282792	70282792	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctttagcttgaagataggtAggtttgtctacatggaagga	11	13	12	5	0	1	2	0	1	1	1	1	4	1	4	1	4	2	3	1	4	6	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:70282792A>T	uc004dyr.1	-	2	248	c.173T>A	c.(172-174)CTA>CAA	p.L58Q	SNX12_uc004dyp.1_RNA|uc004dyq.2_5'Flank	NM_013346	NP_037478	Q9UMY4	SNX12_HUMAN	sorting nexin 12	58	PX.				cell communication|protein transport	membrane	phosphatidylinositol binding|protein binding				0	Renal(35;0.156)					GAAGATAGGTAGGTTTGTCTA	0.453													5	21					0	0	0	0	T	70282792	T	T	70282792	3	4	238	1	0	0	0	0	1	0	0	0	14947	420	15	5	327	5	SNX12	23	70282792	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	2340383	70282792	84987768	298	43591											
MED12	9968	broad.mit.edu	37	chrX	70338650	70338650	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgaacaccggcccctgaagCggccgcggctggggcctccc	6	3	14	18	5	0	1	0	1	0	0	1	2	1	1	6	5	2	1	6	5	2	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:70338650C>G	uc004dyy.2	+	1	245	c.46C>G	c.(46-48)CGG>GGG	p.R16G	MED12_uc011mpq.1_Missense_Mutation_p.R16G|MED12_uc004dyz.2_Missense_Mutation_p.R16G|MED12_uc004dza.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	16				R -> RPR (in Ref. 1; AAD22033).	androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GCCCCTGAAGCGGCCGCGGCT	0.682													4	26					0	0	0	0	G	70338650	G	G	70338650	3	3	238	1	0	0	0	0	1	0	0	0	9481	759	27	3	48	3	MED12	23	70338650	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	55858	70338650	84931910	299	43592											
ITGB1BP2	26548	broad.mit.edu	37	chrX	70523356	70523356	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttccagctgccagaacccagGatgtgatgctgtgagtgaga	10	9	13	9	0	0	4	0	3	0	2	1	6	1	5	3	1	4	2	3	1	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:70523356G>A	uc004dzr.1	+	6	487	c.458G>A	c.(457-459)GGA>GAA	p.G153E	BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_Missense_Mutation_p.G135E	NM_012278	NP_036410	Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein 2	153	Cys-rich.|CHORD 2.				muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)					CAGAACCCAGGATGTGATGCT	0.512													19	89					0	0	0	0	A	70523356	A	A	70523356	3	1	238	1	0	0	0	0	1	0	0	0	7931	1174	41	2	480	2	ITGB1BP2	23	70523356	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	184706	70523356	84747204	300	43593											
TAF1	6872	broad.mit.edu	37	chrX	70614023	70614023	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagaacatgttgcagaacAagaaaaccagctctcagctt	15	9	8	9	0	1	3	1	1	1	3	2	4	1	3	1	0	6	4	1	0	5	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:70614023A>G	uc004dzu.3	+	22	3382	c.3331A>G	c.(3331-3333)AAG>GAG	p.K1111E	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.K1132E|TAF1_uc004dzv.3_Missense_Mutation_p.K285E	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1111					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				GTTGCAGAACAAGAAAACCAG	0.458													13	51					0	0	0	0	G	70614023	G	G	70614023	3	3	238	1	0	0	0	0	1	0	0	0	15579	131	5	5	3480	5	TAF1	23	70614023	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	90667	70614023	84656537	301	43594											
CDX4	1046	broad.mit.edu	37	chrX	72667341	72667341	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccccgcgagaagactggagCgtgtatcctgggccgtctag	7	7	14	13	4	1	2	0	0	1	2	2	4	2	3	4	2	1	1	4	2	3	2	rs146093321		TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:72667341C>T	uc011mqk.1	+	1	252	c.252C>T	c.(250-252)AGC>AGT	p.S84S		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	84						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					AAGACTGGAGCGTGTATCCTG	0.607													8	57					0	0	0	0	T	72667341	T	T	72667341	2	4	238	1	0	0	0	0	0	0	0	1	3199	767	27	1		1	CDX4	23	72667341	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	2053318	72667341	82603219	302	43595											
KIAA2022	340533	broad.mit.edu	37	chrX	73962135	73962135	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taaattagcctttgaggattGgttttccaagagagggctca	11	13	11	6	0	1	2	1	1	0	1	2	4	2	3	2	3	1	2	2	3	4	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:73962135G>T	uc004eby.2	-	3	2874	c.2257C>A	c.(2257-2259)CAA>AAA	p.Q753K		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	753					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTTGAGGATTGGTTTTCCAAG	0.388													14	80					4.3838e-07	5.41607e-07	1	0	T	73962135	T	T	73962135	3	4	238	1	0	0	0	0	1	0	0	0	8308	1357	47	4	2301	4	KIAA2022	23	73962135	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1294794	73962135	81308425	303	43596											
ABCB7	22	broad.mit.edu	37	chrX	74282246	74282246	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaaatggctcttgcaattgCtactctttgcttttctcctc	7	17	5	12	0	3	0	0	0	3	0	5	0	3	0	1	1	4	4	1	1	4	6			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:74282246C>T	uc004eca.2	-	14	1877	c.1852G>A	c.(1852-1854)GCA>ACA	p.A618T	ABCB7_uc004ebz.2_Missense_Mutation_p.A619T|ABCB7_uc011mqn.1_Missense_Mutation_p.A592T|ABCB7_uc010nls.2_Missense_Mutation_p.A579T|ABCB7_uc010nlt.2_Missense_Mutation_p.A578T	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	618	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						CTTGCAATTGCTACTCTTTGC	0.353													8	49					0	0	0	0	T	74282246	T	T	74282246	3	4	238	1	0	0	0	0	1	0	0	0	46	797	28	4	418	4	ABCB7	23	74282246	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	320111	74282246	80988314	304	43597											
UPRT	139596	broad.mit.edu	37	chrX	74494242	74494242	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccagggccaaggtgattctCctcacggggtacgcccattc	7	9	11	14	2	2	1	1	1	1	0	5	1	3	1	4	4	1	1	4	4	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:74494242C>A	uc004ecb.1	+	1	282	c.153C>A	c.(151-153)CTC>CTA	p.L51L	UPRT_uc010nlu.1_Silent_p.L51L|UPRT_uc004ecc.1_RNA|UPRT_uc004ecd.1_Silent_p.L51L|UPRT_uc004ece.1_5'Flank	NM_145052	NP_659489	Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog	51					nucleoside metabolic process	cytoplasm|nucleus					0						AGGTGATTCTCCTCACGGGGT	0.632													6	32					5.9392e-07	7.29312e-07	1	0	A	74494242	A	A	74494242	2	1	238	1	0	0	0	0	0	0	0	1	17082	842	30	2		2	UPRT	23	74494242	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	211996	74494242	80776318	305	43598											
MAGEE1	57692	broad.mit.edu	37	chrX	75650773	75650773	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctatactctgtacaaccGaagggagatggaagaaactg	14	8	10	9	1	1	2	0	0	1	2	2	5	2	3	2	2	4	1	2	2	7	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:75650773G>T	uc004ecm.1	+	1	2657	c.2450G>T	c.(2449-2451)CGA>CTA	p.R817L		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	817	Interaction with DTNA (By similarity).|MAGE 2.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CTGTACAACCGAAGGGAGATG	0.488													10	52					6.40141e-05	7.32626e-05	1	0	T	75650773	T	T	75650773	3	4	238	1	0	0	0	0	1	0	0	0	9238	1058	37	3	2452	3	MAGEE1	23	75650773	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1156531	75650773	79619787	306	43599											
ATRX	546	broad.mit.edu	37	chrX	76944409	76944409	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcagctcacaatcccatGaagcccatcttctaggagaa	13	8	8	12	0	3	2	1	1	2	1	4	3	4	2	2	1	3	2	2	1	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:76944409G>T	uc004ecp.3	-	7	728	c.496C>A	c.(496-498)CAT>AAT	p.H166N	ATRX_uc004ecq.3_Missense_Mutation_p.H128N|ATRX_uc004eco.3_5'UTR|ATRX_uc004ecr.2_Missense_Mutation_p.H127N|ATRX_uc010nlx.1_Missense_Mutation_p.H166N|ATRX_uc010nly.1_Missense_Mutation_p.H111N	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	166	ADD.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ACAATCCCATGAAGCCCATCT	0.358			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						12	98					1.5842e-08	2.06457e-08	1	0	T	76944409	T	T	76944409	3	4	238	1	0	0	0	0	1	0	0	0	1210	1290	45	2	7098	2	ATRX	23	76944409	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1293636	76944409	78326151	307	43600											
PCDH11X	27328	broad.mit.edu	37	chrX	91090898	91090898	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgttttctgatagaagataTaaatgataatgcaccattgt	15	14	7	5	1	1	4	0	2	1	2	1	4	1	4	1	0	1	2	1	0	6	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:91090898T>C	uc004efk.1	+	1	1240	c.395T>C	c.(394-396)ATA>ACA	p.I132T	PCDH11X_uc004efl.1_Missense_Mutation_p.I132T|PCDH11X_uc004efo.1_Missense_Mutation_p.I132T|PCDH11X_uc010nmv.1_Missense_Mutation_p.I132T|PCDH11X_uc004efm.1_Missense_Mutation_p.I132T|PCDH11X_uc004efn.1_Missense_Mutation_p.I132T|PCDH11X_uc004efh.1_Missense_Mutation_p.I132T|PCDH11X_uc004efj.1_Missense_Mutation_p.I132T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	132	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ATAGAAGATATAAATGATAAT	0.388													13	51					0	0	0	0	C	91090898	C	C	91090898	3	2	238	1	0	0	0	0	1	0	0	0	11562	1406	49	5	397	5	PCDH11X	23	91090898	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	14146489	91090898	64179662	308	43601											
DRP2	1821	broad.mit.edu	37	chrX	100510189	100510189	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctaggcttgctgagatggaaAgtcaaaattgctccttcttt	10	14	9	8	0	2	1	1	1	1	1	3	3	3	2	1	2	2	3	1	2	4	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:100510189A>T	uc004egz.2	+	20	2566	c.2197A>T	c.(2197-2199)AGT>TGT	p.S733C	DRP2_uc011mrh.1_Missense_Mutation_p.S655C	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	733					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						TGAGATGGAAAGTCAAAATTG	0.453													19	111					0	0	0	0	T	100510189	T	T	100510189	3	4	238	1	0	0	0	0	1	0	0	0	4786	72	3	5	2267	5	DRP2	23	100510189	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	9419291	100510189	54760371	309	43602											
GPRASP2	114928	broad.mit.edu	37	chrX	101970137	101970137	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctcgttctaaaactgatGccaaggcaatccctggagca	11	8	10	12	2	1	1	0	1	1	0	3	2	2	2	2	2	3	4	2	2	4	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:101970137G>C	uc004ejk.2	+	4	1674	c.340G>C	c.(340-342)GCC>CCC	p.A114P	GPRASP2_uc004ejl.2_Missense_Mutation_p.A114P|GPRASP2_uc004ejm.2_Missense_Mutation_p.A114P|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	114						cytoplasm	protein binding			ovary(1)	1						TAAAACTGATGCCAAGGCAAT	0.577													38	188					0	0	0	0	C	101970137	C	C	101970137	3	2	238	1	0	0	0	0	1	0	0	0	6762	1319	46	4	342	4	GPRASP2	23	101970137	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1459948	101970137	53300423	310	43603											
MORC4	79710	broad.mit.edu	37	chrX	106200165	106200165	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccatctcatgtatactcaaCtgtttcttagctttgctcaa	9	16	4	12	0	4	0	3	0	2	0	5	0	4	0	1	0	4	4	1	0	5	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:106200165C>G	uc004emu.3	-	12	1697	c.1454_splice	c.e12+1	p.Q485_splice	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Splice_Site_p.Q485_splice|MORC4_uc004emw.3_Splice_Site_p.Q233_splice	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2								ATP binding|zinc ion binding			ovary(1)	1						GTATACTCAACTGTTTCTTAG	0.428													7	112					0	0	0	0	G	106200165	G	G	106200165	5	3	238	1	0	0	0	0	0	0	1	0	9757	579	20	4	1382	4	MORC4	23	106200165	Splice_Site	SNP	C	TCGA-CV-7248-01A-11D-2012-08	4230028	106200165	49070395	311	43604											
TEX13B	56156	broad.mit.edu	37	chrX	107224687	107224687	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcaccagcagcagccaccgCctccttttcctgctcacctg	7	8	7	19	1	1	0	1	0	0	0	3	0	3	0	7	0	5	4	7	0	0	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:107224687C>G	uc004enn.1	-	3	655	c.562G>C	c.(562-564)GCG>CCG	p.A188P		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	188										ovary(1)	1						GCAGCCACCGCCTCCTTTTCC	0.652													47	284					0	0	0	0	G	107224687	G	G	107224687	3	3	238	1	0	0	0	0	1	0	0	0	15843	739	26	4	380	4	TEX13B	23	107224687	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1024522	107224687	48045873	312	43605											
IRS4	8471	broad.mit.edu	37	chrX	107978562	107978562	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgctgtagctgcggcagcggGctctgtattcgtctgcacac	5	11	13	12	3	2	0	0	0	2	0	3	0	2	0	0	2	5	7	0	2	2	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:107978562G>T	uc004eoc.2	-	1	1046	c.1013C>A	c.(1012-1014)GCC>GAC	p.A338D		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	338						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GCGGCAGCGGGCTCTGTATTC	0.597													47	275					4.21674e-32	6.60295e-32	1	0	T	107978562	T	T	107978562	3	4	238	1	0	0	0	0	1	0	0	0	7881	1203	42	4	2764	4	IRS4	23	107978562	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	753875	107978562	47291998	313	43606											
RGAG1	57529	broad.mit.edu	37	chrX	109695144	109695144	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaaaagacagttccagcCtctggagccatgaccacctc	11	8	8	14	0	1	2	0	1	1	1	3	3	2	3	5	1	3	2	5	1	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:109695144C>G	uc004eor.1	+	3	1545	c.1299C>G	c.(1297-1299)GCC>GCG	p.A433A	RGAG1_uc011msr.1_Silent_p.A433A	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	433										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CAGTTCCAGCCTCTGGAGCCA	0.512													34	227					0	0	0	0	G	109695144	G	G	109695144	2	3	238	1	0	0	0	0	0	0	0	1	13339	668	24	4		4	RGAG1	23	109695144	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1716582	109695144	45575416	314	43607											
AGTR2	186	broad.mit.edu	37	chrX	115303582	115303582	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctagcaaaaacattaccagcGgtcttcacttcgggcttgtg	10	11	9	11	2	2	0	1	0	1	0	3	0	2	0	1	2	4	2	1	2	4	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:115303582G>T	uc004eqh.3	+	3	256	c.49G>T	c.(49-51)GGT>TGT	p.G17C		NM_000686	NP_000677	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	17	Extracellular (Potential).				behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3						CATTACCAGCGGTCTTCACTT	0.423													19	60					2.94398e-08	3.7878e-08	1	0	T	115303582	T	T	115303582	3	4	238	1	0	0	0	0	1	0	0	0	402	1116	39	3	51	3	AGTR2	23	115303582	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	5608438	115303582	39966978	315	43608											
CXorf61	203413	broad.mit.edu	37	chrX	115593060	115593060	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaattatttaaaatatcccGagagaggtcgtagactgcaa	16	10	9	6	2	0	2	0	0	0	2	2	5	1	2	1	1	1	2	1	1	7	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:115593060G>T	uc004eqj.1	-	2	310	c.190C>A	c.(190-192)CGG>AGG	p.R64R		NM_001017978	NP_001017978	Q5H943	KKLC1_HUMAN	chromosome X open reading frame 61	64	Extracellular (Potential).					integral to membrane|plasma membrane					0						AAAATATCCCGAGAGAGGTCG	0.408													10	102					3.86212e-05	4.45799e-05	1	0	T	115593060	T	T	115593060	2	4	238	1	0	0	0	0	0	0	0	1	4133	1057	37	3		3	CXorf61	23	115593060	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	289478	115593060	39677500	316	43609											
IL13RA1	3597	broad.mit.edu	37	chrX	117880977	117880977	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaatgagaggatttgtctgCaagtggggtcccagtgtagc	9	11	15	6	0	1	2	0	2	1	1	2	4	2	3	1	3	2	2	1	3	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:117880977C>A	uc004eqs.2	+	3	332	c.289C>A	c.(289-291)CAA>AAA	p.Q97K	IL13RA1_uc004eqr.1_Missense_Mutation_p.Q97K|IL13RA1_uc004eqt.1_Missense_Mutation_p.Q97K	NM_001560	NP_001551	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1 precursor	97	Extracellular (Potential).					interleukin-13 receptor complex	cytokine receptor activity				0						GATTTGTCTGCAAGTGGGGTC	0.438													16	85					1.15088e-07	1.45298e-07	1	0	A	117880977	A	A	117880977	3	1	238	1	0	0	0	0	1	0	0	0	7668	711	25	4	299	4	IL13RA1	23	117880977	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	2287917	117880977	37389583	317	43610											
ZCCHC12	170261	broad.mit.edu	37	chrX	117959998	117959998	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtgctgactgcaatgtgaTagagatagatgataccctcg	12	10	11	8	1	0	5	0	3	0	2	1	6	0	5	1	0	3	2	1	0	4	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:117959998T>C	uc004equ.2	+	4	1264	c.791T>C	c.(790-792)ATA>ACA	p.I264T		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						TGCAATGTGATAGAGATAGAT	0.567													12	82					0	0	0	0	C	117959998	C	C	117959998	3	2	238	1	0	0	0	0	1	0	0	0	17648	1406	49	5	793	5	ZCCHC12	23	117959998	Missense_Mutation	SNP	T	TCGA-CV-7248-01A-11D-2012-08	79021	117959998	37310562	318	43611											
RNF113A	7737	broad.mit.edu	37	chrX	119005629	119005630	+	Translation_Start_Site	DNP	CC	AT	AT																															tgcctgggttgcacttggccCctgcacgtcactccacgttg																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:119005629_119005630CC>AT	uc004esb.2	-	1	162_163	c.-53_-52GG>AT	c.(-55--50)CAGGGG>CAATGG		NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A								nucleic acid binding|zinc ion binding			breast(2)	2						GCACTTGGCCCCTGCACGTCAC	0.619													6	30					0	0	0	0	AT	119005630	AT	AT	119005629	1	1	238	1	0	0	0	0	0	0	0	0	13492	638	22	4		4	RNF113A	23	119005629	Translation_Start_Site	DNP	CC	TCGA-CV-7248-01A-11D-2012-08	1045631	119005629	36264931	319	43612											
ZBTB33	10009	broad.mit.edu	37	chrX	119389152	119389152	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggaaaagaacctccagtaGggaccactacatctactcag	14	7	8	12	0	2	1	1	0	1	1	3	3	3	3	3	2	3	1	3	2	6	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:119389152G>C	uc004esn.1	+	2	2110	c.1882G>C	c.(1882-1884)GGG>CGG	p.G628R	ZBTB33_uc010nqm.1_Missense_Mutation_p.G628R	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	628	Interaction with CTNND1 (By similarity).|Required for DNA-binding (By similarity).				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						ACCTCCAGTAGGGACCACTAC	0.383													13	88					0	0	0	0	C	119389152	C	C	119389152	3	2	238	1	0	0	0	0	1	0	0	0	17603	1000	35	4	1884	4	ZBTB33	23	119389152	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	383523	119389152	35881408	320	43613											
CUL4B	8450	broad.mit.edu	37	chrX	119694442	119694442	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtggcagatctgacctcctGagcagcagcagcagctgagg	10	6	14	11	0	1	4	0	3	1	1	2	4	2	4	2	2	5	6	2	2	0	0			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:119694442G>A	uc004esw.2	-	3	543	c.106C>T	c.(106-108)CAG>TAG	p.Q36*	CUL4B_uc004esv.2_Nonsense_Mutation_p.Q18*	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	36	Ser-rich.				cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						CTGACCTCCTGAGCAGCAGCA	0.433													5	16					0	0	0	0	A	119694442	A	A	119694442	4	1	238	1	0	0	0	0	0	1	0	0	4075	1299	45	2	2715	2	CUL4B	23	119694442	Nonsense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	305290	119694442	35576118	321	43614											
STAG2	10735	broad.mit.edu	37	chrX	123181323	123181323	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaaaacgagccaatgagAggctagaactcctgctacaa	15	7	10	9	1	0	2	0	1	0	2	1	5	1	3	2	2	5	2	2	2	7	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:123181323A>C	uc004etz.3	+	8	1126	c.787A>C	c.(787-789)AGG>CGG	p.R263R	STAG2_uc004eua.2_Silent_p.R263R|STAG2_uc004eub.2_Silent_p.R263R|STAG2_uc004euc.2_Silent_p.R263R|STAG2_uc004eud.2_Silent_p.R263R|STAG2_uc004eue.2_Silent_p.R263R	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	263					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						AGCCAATGAGAGGCTAGAACT	0.348													10	55					0	0	0	0	C	123181323	C	C	123181323	2	2	238	1	0	0	0	0	0	0	0	1	15309	295	11	5		5	STAG2	23	123181323	Silent	SNP	A	TCGA-CV-7248-01A-11D-2012-08	3486881	123181323	32089237	322	43615											
SH2D1A	4068	broad.mit.edu	37	chrX	123480493	123480493	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccaagagtccaccaggccAtggacgcagtggctgtgtat	9	7	13	12	1	0	1	0	0	0	1	1	2	1	2	4	3	0	3	4	3	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:123480493A>G	uc004euf.3	+	1	346	c.1A>G	c.(1-3)ATG>GTG	p.M1V	SH2D1A_uc004euh.3_Missense_Mutation_p.M1V|SH2D1A_uc004eug.3_RNA|SH2D1A_uc010nqw.2_RNA|SH2D1A_uc004eui.3_RNA|SH2D1A_uc010nqx.2_Intron	NM_002351	NP_002342	O60880	SH21A_HUMAN	SH2 domain protein 1A isoform 1	1					cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity				0						CCACCAGGCCATGGACGCAGT	0.592									X-linked_Lymphoproliferative_syndrome				14	100					0	0	0	0	G	123480493	G	G	123480493	3	3	238	1	0	0	0	0	1	0	0	0	14295	217	8	5	3	5	SH2D1A	23	123480493	Missense_Mutation	SNP	A	TCGA-CV-7248-01A-11D-2012-08	299170	123480493	31790067	323	43616											
ODZ1	10178	broad.mit.edu	37	chrX	123805604	123805604	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccatggactcggtccccCtgttccctttgctaactcca	5	13	7	16	1	0	0	0	0	0	0	5	1	4	1	5	2	2	2	5	2	1	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:123805604C>A	uc004euj.2	-	6	1161	c.1097G>T	c.(1096-1098)AGG>ATG	p.R366M	ODZ1_uc011muj.1_Missense_Mutation_p.R365M|ODZ1_uc010nqy.2_Missense_Mutation_p.R366M	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	366	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTCGGTCCCCCTGTTCCCTTT	0.438													26	145					3.6726e-16	5.37584e-16	1	0	A	123805604	A	A	123805604	3	1	238	1	0	0	0	0	1	0	0	0	10888	681	24	4	7209	4	ODZ1	23	123805604	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	325111	123805604	31464956	324	43617											
ACTRT1	139741	broad.mit.edu	37	chrX	127185945	127185945	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctccatgtcatcccatcCtgttaccagtccacgctcaa	8	13	4	16	1	3	0	2	0	1	0	7	0	6	0	5	0	1	2	5	0	2	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:127185945C>A	uc004eum.2	-	1	438	c.241G>T	c.(241-243)GGA>TGA	p.G81*		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	81						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						TCATCCCATCCTGTTACCAGT	0.483													57	243					1.0442e-30	1.62879e-30	1	0	A	127185945	A	A	127185945	4	1	238	1	0	0	0	0	0	1	0	0	218	690	24	4	893	4	ACTRT1	23	127185945	Nonsense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3380341	127185945	28084615	325	43618											
MOSPD1	56180	broad.mit.edu	37	chrX	134033180	134033180	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caacgacaacatacttatttGgagtagtacacaaaactgaa	18	9	6	8	1	0	1	0	1	0	0	0	3	0	2	0	1	5	2	0	1	9	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:134033180G>T	uc004eyb.2	-	3	357	c.170C>A	c.(169-171)CCA>CAA	p.P57Q	MOSPD1_uc004eya.2_Missense_Mutation_p.P57Q|MOSPD1_uc010nrv.2_Intron|MOSPD1_uc011mvr.1_Missense_Mutation_p.P57Q	NM_019556	NP_062456	Q9UJG1	MSPD1_HUMAN	motile sperm domain containing 1	57	MSP.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	integral to membrane|nucleus|perinuclear region of cytoplasm	structural molecule activity			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(192;0.000127)					ATACTTATTTGGAGTAGTACA	0.343													30	119					3.65163e-15	5.28766e-15	1	0	T	134033180	T	T	134033180	3	4	238	1	0	0	0	0	1	0	0	0	9768	1348	47	4	487	4	MOSPD1	23	134033180	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	6847235	134033180	21237380	326	43619											
FHL1	2273	broad.mit.edu	37	chrX	135288651	135288651	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgcaggggaagaagtatgtGcaaaaggatggccaccactg	13	7	14	7	0	0	1	0	0	0	1	0	3	0	3	2	4	2	3	2	4	5	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:135288651G>C	uc004ezo.2	+	2	160	c.60G>C	c.(58-60)GTG>GTC	p.V20V	FHL1_uc010nrz.2_Silent_p.V20V|FHL1_uc004ezm.2_RNA|FHL1_uc004ezl.2_Silent_p.V20V|FHL1_uc004ezq.2_Silent_p.V20V|FHL1_uc011mvy.1_Silent_p.V20V|FHL1_uc011mvz.1_Silent_p.V20V|FHL1_uc004ezn.2_Silent_p.V20V|FHL1_uc011mwa.1_Silent_p.V49V|FHL1_uc011mwb.1_RNA|FHL1_uc004ezp.2_Silent_p.V36V|FHL1_uc004ezr.2_5'Flank	NM_001159702	NP_001153174	Q13642	FHL1_HUMAN	four and a half LIM domains 1 isoform 1	20	C4-type (Potential).				cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)					AGAAGTATGTGCAAAAGGATG	0.567													38	215					0	0	0	0	C	135288651	C	C	135288651	2	2	238	1	0	0	0	0	0	0	0	1	5910	1306	46	4		4	FHL1	23	135288651	Silent	SNP	G	TCGA-CV-7248-01A-11D-2012-08	1255471	135288651	19981909	327	43620											
GPR112	139378	broad.mit.edu	37	chrX	135426794	135426794	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagacactggtagatgagaCagctacatttgcagtggatg	14	9	12	6	0	0	3	0	1	0	3	0	5	0	4	0	2	3	3	0	2	3	3			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:135426794C>A	uc004ezu.1	+	6	1220	c.929C>A	c.(928-930)ACA>AAA	p.T310K	GPR112_uc010nsb.1_Missense_Mutation_p.T105K|GPR112_uc010nsc.1_Missense_Mutation_p.T77K	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	310	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GTAGATGAGACAGCTACATTT	0.378													11	67					4.36969e-10	5.88452e-10	1	0	A	135426794	A	A	135426794	3	1	238	1	0	0	0	0	1	0	0	0	6667	478	17	4	939	4	GPR112	23	135426794	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	138143	135426794	19843766	328	43621											
GPR112	139378	broad.mit.edu	37	chrX	135482271	135482271	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttaaattttgtctagttggTtggggtaagtatatctgcca	9	17	10	5	0	2	0	0	0	2	0	2	0	2	0	1	3	1	4	1	3	6	9			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:135482271T>A	uc004ezu.1	+	21	8862	c.8571T>A	c.(8569-8571)GGT>GGA	p.G2857G	GPR112_uc010nsb.1_Silent_p.G2652G	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2857	Helical; Name=4; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GTCTAGTTGGTTGGGGTAAGT	0.333													8	60					0	0	0	0	A	135482271	A	A	135482271	2	1	238	1	0	0	0	0	0	0	0	1	6667	1712	60	5		5	GPR112	23	135482271	Silent	SNP	T	TCGA-CV-7248-01A-11D-2012-08	55477	135482271	19788289	329	43622											
MCF2	4168	broad.mit.edu	37	chrX	138670521	138670521	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcaggcttgaatttacctGtcaaaagttcctgctgcttc	9	14	8	10	0	1	1	1	1	0	0	3	1	2	1	2	1	4	5	2	1	4	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:138670521G>T	uc004fau.2	-	21	2741	c.2447C>A	c.(2446-2448)ACA>AAA	p.T816K	MCF2_uc004fav.2_Missense_Mutation_p.T832K|MCF2_uc011mwl.1_Missense_Mutation_p.T793K|MCF2_uc010nsh.1_Missense_Mutation_p.T816K|MCF2_uc011mwm.1_Missense_Mutation_p.T777K|MCF2_uc011mwn.1_Missense_Mutation_p.T961K|MCF2_uc004faw.2_Missense_Mutation_p.T876K|MCF2_uc011mwo.1_Missense_Mutation_p.T892K	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	816					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					GAATTTACCTGTCAAAAGTTC	0.328													10	39					2.17888e-05	2.5515e-05	1	0	T	138670521	T	T	138670521	3	4	238	1	0	0	0	0	1	0	0	0	9431	1377	48	4	378	4	MCF2	23	138670521	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	3188250	138670521	16600039	330	43623											
ATP11C	286410	broad.mit.edu	37	chrX	138844238	138844238	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aataatcgctattcctagctGcttggcgaccttctttgcct	7	15	7	12	2	1	0	0	0	1	0	3	1	2	0	3	1	3	3	3	1	4	7			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:138844238G>T	uc004faz.2	-	22	2630	c.2531C>A	c.(2530-2532)GCA>GAA	p.A844E	ATP11C_uc004fax.2_Missense_Mutation_p.A52E|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.A844E	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	844	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					ATTCCTAGCTGCTTGGCGACC	0.363													27	136					3.1745e-13	4.49999e-13	1	0	T	138844238	T	T	138844238	3	4	238	1	0	0	0	0	1	0	0	0	1123	1319	46	4	966	4	ATP11C	23	138844238	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	173717	138844238	16426322	331	43624											
CDR1	1038	broad.mit.edu	37	chrX	139866430	139866430	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagcctacttgtgtcttcCaacaaaggtacgtcttccaa	10	12	6	13	1	2	0	0	0	2	0	5	0	5	0	4	1	4	1	4	1	5	5			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:139866430C>T	uc004fbg.1	-	1	294	c.102G>A	c.(100-102)TTG>TTA	p.L34L	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	34	23 X 6 AA approximate repeats.|6.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				TTGTGTCTTCCAACAAAGGTA	0.453													33	207					0	0	0	0	T	139866430	T	T	139866430	2	4	238	1	0	0	0	0	0	0	0	1	3186	593	21	4		4	CDR1	23	139866430	Silent	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1022192	139866430	15404130	332	43625											
UBE2NL	389898	broad.mit.edu	37	chrX	142967601	142967601	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggagcagtggaagaccaaCgaagcccaagccattgaaac	15	4	12	10	1	0	2	0	1	0	1	0	5	0	4	3	2	5	1	3	2	5	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:142967601C>A	uc004fca.2	+	1	429	c.399C>A	c.(397-399)AAC>AAA	p.N133K		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	133							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					GGAAGACCAACGAAGCCCAAG	0.438													9	101					4.68919e-08	5.97613e-08	1	0	A	142967601	A	A	142967601	3	1	238	1	0	0	0	0	1	0	0	0	16935	535	19	3	401	3	UBE2NL	23	142967601	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	3101171	142967601	12302959	333	43626											
MAGEA11	4110	broad.mit.edu	37	chrX	148798378	148798378	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caatgccaatgggagggatcCcacttcttacccatccctgt	9	10	8	14	0	1	0	0	0	1	0	3	2	3	2	4	2	2	0	4	2	3	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:148798378C>A	uc004fdq.2	+	5	1334	c.1232C>A	c.(1231-1233)CCC>CAC	p.P411H	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.P382H	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	411	MAGE.					cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GGGAGGGATCCCACTTCTTAC	0.547													24	168					5.45024e-15	7.83593e-15	1	0	A	148798378	A	A	148798378	3	1	238	1	0	0	0	0	1	0	0	0	9216	623	22	4	1259	4	MAGEA11	23	148798378	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	5830777	148798378	6472182	334	43627											
MAGEA5	4104	broad.mit.edu	37	chrX	151283933	151283934	+	Missense_Mutation	DNP	CC	AA	AA																															cagtagtggcagcctgcacaCccaccaggcccagggcctct																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:151283933_151283934CC>AA	uc004ffj.2	-	3	284_285	c.79_80GG>TT	c.(79-81)GGT>TTT	p.G27F		NM_021049	NP_066387	P43359	MAGA5_HUMAN	melanoma antigen family A, 5	27	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					AGCCTGCACACCCACCAGGCCC	0.624													20	115					0	0	0	0	AA	151283934	AA	AA	151283933	3	1	238	1	0	0	0	0	1	0	0	0	9220	507	18	4	298	4	MAGEA5	23	151283933	Missense_Mutation	DNP	CC	TCGA-CV-7248-01A-11D-2012-08	2485555	151283933	3986627	335	43628											
MAGEA3	4102	broad.mit.edu	37	chrX	151939495	151939496	+	5'Flank	INS	-	G	G																															tactcctctatgtatttcaaINSgcttttttttacctgaatat																										TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:151939495_151939496insG	uc004fgp.2	-							NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3												0	Acute lymphoblastic leukemia(192;6.56e-05)					atgtatttcaagctttttttta	0.02													---	---	---								G	151939496	G	G	151939495	6	5	238	0	1	1	1	0	0	0	0	0	9218	87	3	0		0	MAGEA3	23	151939495	5'Flank	INS	-	TCGA-CV-7248-01A-11D-2012-08	655562	151939495	3331065	336	43629											
SRPK3	26576	broad.mit.edu	37	chrX	153046726	153046726	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgaactagccctggccacaCcggtgcctcagatgctgcag	8	6	11	16	2	1	1	1	0	0	1	1	2	1	1	5	2	5	2	5	2	2	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:153046726C>A	uc004fil.2	+	2	147	c.115C>A	c.(115-117)CCG>ACG	p.P39T	SRPK3_uc004fik.2_Missense_Mutation_p.P105T|SRPK3_uc010nul.2_Intron|SRPK3_uc004fin.2_Missense_Mutation_p.P39T|SRPK3_uc004fim.2_Missense_Mutation_p.P39T	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	39					cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTGGCCACACCGGTGCCTCA	0.662													9	44					0.000274275	0.000308655	1	0	A	153046726	A	A	153046726	3	1	238	1	0	0	0	0	1	0	0	0	15227	507	18	4	121	4	SRPK3	23	153046726	Missense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	1107231	153046726	2223834	337	43630											
SRPK3	26576	broad.mit.edu	37	chrX	153049747	153049747	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccctgctctgccttccccAgcaccattcggtgcctcgaa	5	10	7	19	2	1	0	0	0	1	0	5	1	3	0	6	1	4	2	6	1	1	2			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:153049747A>T	uc004fil.2	+	11	1180	c.1148_splice	c.e11-2	p.T383_splice	SRPK3_uc004fik.2_Splice_Site_p.T449_splice|SRPK3_uc010nul.2_Splice_Site_p.T307_splice|SRPK3_uc004fin.2_Splice_Site_p.T382_splice|SRPK3_uc004fim.2_Splice_Site_p.T349_splice	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3						cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TGCCTTCCCCAGCACCATTCG	0.612													12	56					0	0	0	0	T	153049747	T	T	153049747	5	4	238	1	0	0	0	0	0	0	1	0	15227	202	7	5	1188	5	SRPK3	23	153049747	Splice_Site	SNP	A	TCGA-CV-7248-01A-11D-2012-08	3021	153049747	2220813	338	43631											
HCFC1	3054	broad.mit.edu	37	chrX	153218076	153218076	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcagccgtcactgccagctCctcgggggtgagccccgtta	6	7	13	15	3	1	1	1	1	0	0	3	1	2	1	5	2	5	3	5	2	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:153218076C>A	uc004fjp.2	-	19	5359	c.4831G>T	c.(4831-4833)GAG>TAG	p.E1611*		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1611					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACTGCCAGCTCCTCGGGGGTG	0.662													11	49					1.58986e-06	1.91733e-06	1	0	A	153218076	A	A	153218076	4	1	238	1	0	0	0	0	0	1	0	0	7030	864	30	2	1308	2	HCFC1	23	153218076	Nonsense_Mutation	SNP	C	TCGA-CV-7248-01A-11D-2012-08	168329	153218076	2052484	339	43632											
GAB3	139716	broad.mit.edu	37	chrX	153944560	153944560	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccaagacatcggggttgccGctcatgcggcctcgccggag	6	7	14	14	5	1	1	1	0	0	1	4	2	2	2	4	4	2	2	4	4	1	1			TCGA-CV-7248-01A-11D-2012-08	TCGA-CV-7248-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	8ffc7f9d-16da-4cff-b845-f2ff8df87569	2d3f7bb7-7361-4710-a65a-2e7df5df9b7c	g.chrX:153944560G>T	uc004fmj.1	-	2	165	c.117C>A	c.(115-117)AGC>AGA	p.S39R	GAB3_uc004fmk.1_Missense_Mutation_p.S39R|GAB3_uc010nve.1_Missense_Mutation_p.S39R|GAB3_uc004fml.1_5'UTR	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	39	PH.									ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGGGGTTGCCGCTCATGCGGC	0.562													10	56					0.000442599	0.00049259	1	0	T	153944560	T	T	153944560	3	4	238	1	0	0	0	0	1	0	0	0	6184	1078	38	3	1682	3	GAB3	23	153944560	Missense_Mutation	SNP	G	TCGA-CV-7248-01A-11D-2012-08	726484	153944560	1326000	340	43633											
PLEKHN1	84069	broad.mit.edu	37	chr1	906364	906364	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctcctcggggggccgcggcGctgccactcggcacccccac	3	4	13	21	5	0	0	0	0	0	0	3	0	1	0	6	5	1	2	6	5	0	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:906364G>A	uc001ace.2	+	5	745	c.710G>A	c.(709-711)CGC>CAC	p.R237H	PLEKHN1_uc001acd.2_Missense_Mutation_p.R197H|PLEKHN1_uc001acf.2_Missense_Mutation_p.R197H	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	237											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		GGGCCGCGGCGCTGCCACTCG	0.736													5	10					0	0	0	0	A	906364	A	A	906364	3	1	239	1	0	0	0	0	1	0	0	0	12138	1087	38	1	612	1	PLEKHN1	1	906364	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08		906364	248344257	1	43634											
TARDBP	23435	broad.mit.edu	37	chr1	11082376	11082376	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggtttgggaaacaatcaaGgtagtaatatgggtggtggg	11	11	16	3	0	1	0	1	0	0	0	1	1	1	1	0	6	1	3	0	6	6	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:11082376G>A	uc001art.2	+	6	1044	c.910G>A	c.(910-912)GGT>AGT	p.G304S	TARDBP_uc010oap.1_Missense_Mutation_p.G188S	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	304	Gly-rich.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		AAACAATCAAGGTAGTAATAT	0.498													6	60					0	0	0	0	A	11082376	A	A	11082376	3	1	239	1	0	0	0	0	1	0	0	0	15623	1000	35	4	928	4	TARDBP	1	11082376	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	10176012	11082376	238168245	2	43635											
PRDM2	7799	broad.mit.edu	37	chr1	14107331	14107331	+	Frame_Shift_Del	DEL	C	-	-																															cccctctccactctcaaatgCcaccgcacagtccccacttc																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:14107331delC	uc001avi.2	+	8	3897	c.3041delC	c.(3040-3042)GCCfs	p.A1014fs	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Frame_Shift_Del_p.A1014fs|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Frame_Shift_Del_p.A813fs|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1014	Pro-rich.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CTCTCAAATGCCACCGCACAG	0.632													---	---	---								-	14107331	-	-	14107331	7	5	239	1	0	1	0	1	0	0	0	0	12520	739	26	0	3067	0	PRDM2	1	14107331	Frame_Shift_Del	DEL	C	TCGA-CV-7250-01A-11D-2012-08	3024955	14107331	235143290	3	43636											
CLSPN	63967	broad.mit.edu	37	chr1	36226310	36226311	+	Frame_Shift_Ins	INS	-	T	T																															cctgaatttctagctcttcaINSttttttaccaaatccttcct																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:36226310_36226311insT	uc001bzi.2	-	8	1291_1292	c.1211_1212insA	c.(1210-1212)AATfs	p.N404fs	CLSPN_uc009vux.2_Frame_Shift_Ins_p.N404fs	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	404					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTAGCTCTTCATTTTTTACCAA	0.436													---	---	---								T	36226311	T	T	36226310	7	5	239	1	0	1	1	0	0	0	0	0	3575	214	8	0	2879	0	CLSPN	1	36226310	Frame_Shift_Ins	INS	-	TCGA-CV-7250-01A-11D-2012-08	22118979	36226310	213024311	4	43637											
HIVEP3	59269	broad.mit.edu	37	chr1	41978886	41978886	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttggggctgaggcctgtggTtctcgggccggggagcatcg	3	9	19	10	3	1	1	0	1	1	0	3	2	1	2	2	7	1	3	2	7	0	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:41978886T>A	uc001cgz.3	-	8	7219	c.6006A>T	c.(6004-6006)GAA>GAT	p.E2002D	HIVEP3_uc001cha.3_Missense_Mutation_p.E2002D|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	2002					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGCCTGTGGTTCTCGGGCCG	0.632													30	44					0	0	0	0	A	41978886	A	A	41978886	3	1	239	1	0	0	0	0	1	0	0	0	7227	1722	60	5	1222	5	HIVEP3	1	41978886	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	5752576	41978886	207271735	5	43638											
HIVEP3	59269	broad.mit.edu	37	chr1	42050284	42050284	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttccctaagaactgatgagGggcccgggaagggctgcggg	8	6	17	10	2	0	3	0	2	0	1	1	4	1	4	2	5	2	1	2	5	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:42050284G>A	uc001cgz.3	-	4	1398	c.185C>T	c.(184-186)CCC>CTC	p.P62L	HIVEP3_uc001cha.3_Missense_Mutation_p.P62L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	62					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AACTGATGAGGGGCCCGGGAA	0.622													46	76					0	0	0	0	A	42050284	A	A	42050284	3	1	239	1	0	0	0	0	1	0	0	0	7227	1232	43	4	7059	4	HIVEP3	1	42050284	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	71398	42050284	207200337	6	43639											
C8B	732	broad.mit.edu	37	chr1	57422503	57422503	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcatggtctgttggtaacAcagtcttcgacttccttgtc	6	14	9	12	2	2	0	0	0	2	0	5	1	3	0	2	2	1	3	2	2	1	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:57422503A>G	uc001cyp.2	-	3	397	c.330T>C	c.(328-330)TGT>TGC	p.C110C	C8B_uc010oon.1_Silent_p.C48C|C8B_uc010ooo.1_Silent_p.C58C	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	110	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TGTTGGTAACACAGTCTTCGA	0.498													28	222					0	0	0	0	G	57422503	G	G	57422503	2	3	239	1	0	0	0	0	0	0	0	1	2428	157	6	5		5	C8B	1	57422503	Silent	SNP	A	TCGA-CV-7250-01A-11D-2012-08	15372219	57422503	191828118	7	43640											
LRRC40	55631	broad.mit.edu	37	chr1	70616847	70616847	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatcgtttgcagtcttaccAgtgattccatttcttctggc	6	17	8	10	1	3	2	0	2	3	0	5	2	4	2	2	1	2	2	2	1	1	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:70616847A>T	uc001der.1	-	13	1533	c.1481T>A	c.(1480-1482)CTG>CAG	p.L494Q		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	494	LRR 16.									ovary(1)	1						CAGTCTTACCAGTGATTCCAT	0.284													10	19					0	0	0	0	T	70616847	T	T	70616847	3	4	239	1	0	0	0	0	1	0	0	0	9048	188	7	5	339	5	LRRC40	1	70616847	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	13194344	70616847	178633774	8	43641											
C1orf173	127254	broad.mit.edu	37	chr1	75038758	75038758	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactgtgagcatcaaggctTgcttttcaggagcctcatct	8	12	10	11	0	4	1	3	1	1	0	4	2	4	2	1	2	3	4	1	2	1	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:75038758T>C	uc001dgg.2	-	14	2855	c.2636A>G	c.(2635-2637)CAA>CGA	p.Q879R		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	879	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CATCAAGGCTTGCTTTTCAGG	0.527													72	156					0	0	0	0	C	75038758	C	C	75038758	3	2	239	1	0	0	0	0	1	0	0	0	2023	1812	63	5	1960	5	C1orf173	1	75038758	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	4421911	75038758	174211863	9	43642											
HFM1	164045	broad.mit.edu	37	chr1	91859650	91859650	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttaattataataattacCttttccggaatactgatgtg	13	17	6	5	1	0	1	0	1	0	0	1	2	1	2	2	1	2	1	2	1	7	9			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:91859650C>G	uc001doa.3	-	4	594	c.494G>C	c.(493-495)AGA>ACA	p.R165T	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.R165T	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	165							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		taataattaCCTTTTCCGGAA	0.284													9	10					0	0	0	0	G	91859650	G	G	91859650	3	3	239	1	0	0	0	0	1	0	0	0	7122	695	24	4	3957	4	HFM1	1	91859650	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	16820892	91859650	157390971	10	43643											
ARHGAP29	9411	broad.mit.edu	37	chr1	94669495	94669495	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacacttacctgaattccAatgttagttctagttgcctc	11	14	6	10	0	1	2	0	1	1	1	3	2	2	2	3	0	3	3	3	0	6	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:94669495A>G	uc001dqj.3	-	8	1122	c.753T>C	c.(751-753)ATT>ATC	p.I251I	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Silent_p.I251I	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	251					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CCTGAATTCCAATGTTAGTTC	0.338													7	26					0	0	0	0	G	94669495	G	G	94669495	2	3	239	1	0	0	0	0	0	0	0	1	878	126	5	5		5	ARHGAP29	1	94669495	Silent	SNP	A	TCGA-CV-7250-01A-11D-2012-08	2809845	94669495	154581126	11	43644											
LPPR4	9890	broad.mit.edu	37	chr1	99772018	99772018	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatcatgcaagtcatagccAtgtccaagcagcagggtgtc	12	8	11	10	0	2	0	2	0	0	0	4	1	3	0	2	1	4	3	2	1	4	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:99772018A>C	uc001dse.2	+	7	1850	c.1744A>C	c.(1744-1746)ATG>CTG	p.M582L	LPPR4_uc010oue.1_Missense_Mutation_p.M524L	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	582							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGTCATAGCCATGTCCAAGCA	0.537													23	47					0	0	0	0	C	99772018	C	C	99772018	3	2	239	1	0	0	0	0	1	0	0	0	8977	217	8	5	1770	5	LPPR4	1	99772018	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	5102523	99772018	149478603	12	43645											
COL11A1	1301	broad.mit.edu	37	chr1	103400075	103400075	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cacctttttgcccaaacatcCcctgctgtcctctaggacct	7	12	5	17	0	1	0	0	0	1	0	3	1	3	1	6	1	3	1	6	1	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:103400075C>T	uc001dul.2	-	46	3848	c.3530G>A	c.(3529-3531)GGG>GAG	p.G1177E	COL11A1_uc001duk.2_Missense_Mutation_p.G373E|COL11A1_uc001dum.2_Missense_Mutation_p.G1189E|COL11A1_uc001dun.2_Missense_Mutation_p.G1138E|COL11A1_uc009weh.2_Missense_Mutation_p.G1061E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1177	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCCAAACATCCCCTGCTGTCC	0.448													16	49					0	0	0	0	T	103400075	T	T	103400075	3	4	239	1	0	0	0	0	1	0	0	0	3682	623	22	4	1978	4	COL11A1	1	103400075	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	3628057	103400075	145850546	13	43646											
SV2A	9900	broad.mit.edu	37	chr1	149876628	149876628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagagagctgccaagggcaaGggcagctgaggcaaagagga	14	2	17	8	0	0	3	0	1	0	2	0	5	0	4	1	4	3	5	1	4	3	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:149876628G>A	uc001etg.2	-	13	2658	c.2167C>T	c.(2167-2169)CTT>TTT	p.L723F	SV2A_uc009wlk.2_Missense_Mutation_p.L175F	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	723	Helical; (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CCAAGGGCAAGGGCAGCTGAG	0.602													7	27					0	0	0	0	A	149876628	A	A	149876628	3	1	239	1	0	0	0	0	1	0	0	0	15483	1000	35	4	65	4	SV2A	1	149876628	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	46476553	149876628	99373993	14	43647											
ARNT	405	broad.mit.edu	37	chr1	150808901	150808901	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagtcagacacatacaccacCctgcctgtctcacatgagac	12	7	7	15	0	2	2	2	1	1	2	3	4	2	2	3	0	2	0	3	0	1	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:150808901C>A	uc001evr.1	-	7	698	c.555G>T	c.(553-555)AGG>AGT	p.R185S	ARNT_uc001evs.1_Missense_Mutation_p.R170S|ARNT_uc009wmb.1_Missense_Mutation_p.R176S|ARNT_uc009wmc.1_Missense_Mutation_p.R185S|ARNT_uc009wmd.1_Missense_Mutation_p.R170S|ARNT_uc009wme.1_Missense_Mutation_p.R185S|ARNT_uc010pcl.1_Missense_Mutation_p.R169S	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	185	PAS 1.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			CATACACCACCCTGCCTGTCT	0.453			T	ETV6	AML								11	40					3.86212e-05	0.000146906	1	0	A	150808901	A	A	150808901	3	1	239	1	0	0	0	0	1	0	0	0	967	622	22	4	1878	4	ARNT	1	150808901	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	932273	150808901	98441720	15	43648											
LASS2	29956	broad.mit.edu	37	chr1	150941485	150941485	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcgtagacacgtccatctcGgtcttctagatcggcccagg	7	9	12	13	4	3	2	0	0	3	2	6	2	4	2	2	4	0	1	2	4	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:150941485G>A	uc001evy.2	-	2	469	c.82C>T	c.(82-84)CGA>TGA	p.R28*	LASS2_uc001evz.2_Nonsense_Mutation_p.R28*|LASS2_uc009wmh.2_Intron	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	28	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CGTCCATCTCGGTCTTCTAGA	0.527													8	47					0	0	0	0	A	150941485	A	A	150941485	4	1	239	1	0	0	0	0	0	1	0	0	8679	1124	39	1	1100	1	LASS2	1	150941485	Nonsense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	132584	150941485	98309136	16	43649											
CD1D	912	broad.mit.edu	37	chr1	158152775	158152775	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctgtatgggtgaagtggAtgcggggtgagcaggagcag	9	7	20	5	1	0	2	0	2	0	0	0	4	0	4	1	5	4	3	1	5	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:158152775A>T	uc001frr.2	+	5	1214	c.715A>T	c.(715-717)ATG>TTG	p.M239L	CD1D_uc009wss.2_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	239	Ig-like.|Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					GGTGAAGTGGATGCGGGGTGA	0.627													10	133					0	0	0	0	T	158152775	T	T	158152775	3	4	239	1	0	0	0	0	1	0	0	0	2992	333	12	5	729	5	CD1D	1	158152775	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	7211290	158152775	91097846	17	43650											
CD84	8832	broad.mit.edu	37	chr1	160520798	160520798	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttgaagccatgatatatGtgtatatggttttctttgag	9	18	9	5	0	1	3	0	3	1	0	2	3	2	3	2	1	1	2	2	1	5	8			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:160520798G>C	uc001fwh.3	-	6	863	c.839C>G	c.(838-840)ACA>AGA	p.T280R	CD84_uc001fwf.3_Missense_Mutation_p.T263R|CD84_uc001fwg.3_Missense_Mutation_p.T274R|CD84_uc009wtn.2_Intron|CD84_uc001fwi.3_Missense_Mutation_p.T149R	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	280	Cytoplasmic (Potential).|ITSM motif 1.				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CATGATATATGTGTATATGGT	0.383													20	318					0	0	0	0	C	160520798	C	C	160520798	3	2	239	1	0	0	0	0	1	0	0	0	3057	1377	48	4	210	4	CD84	1	160520798	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	2368023	160520798	88729823	18	43651											
RXRG	6258	broad.mit.edu	37	chr1	165398200	165398200	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tagagccagtgtggccagggGagcctgtaagaagaagaata	14	6	15	6	0	0	4	0	0	0	4	0	5	0	5	3	3	2	1	3	3	6	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:165398200G>A	uc001gda.2	-	2	353	c.53C>T	c.(52-54)TCC>TTC	p.S18F		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	18	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GTGGCCAGGGGAGCCTGTAAG	0.567													18	22					0	0	0	0	A	165398200	A	A	165398200	3	1	239	1	0	0	0	0	1	0	0	0	13830	1174	41	2	1374	2	RXRG	1	165398200	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	4877402	165398200	83852421	19	43652											
LGR6	59352	broad.mit.edu	37	chr1	202287594	202287594	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactctgcctgccctacgcGccacctgagggtcagccagc	6	6	10	19	2	2	1	1	1	1	0	2	1	2	1	6	1	5	0	6	1	1	1	rs140182035		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:202287594G>A	uc001gxu.2	+	18	2163	c.2163G>A	c.(2161-2163)GCG>GCA	p.A721A	LGR6_uc001gxv.2_Silent_p.A669A|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Silent_p.A582A	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	721	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TGCCCTACGCGCCACCTGAGG	0.667													10	33					0	0	0	0	A	202287594	A	A	202287594	2	1	239	1	0	0	0	0	0	0	0	1	8799	1074	38	1		1	LGR6	1	202287594	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	36889394	202287594	46963027	20	43653											
PPFIA4	8497	broad.mit.edu	37	chr1	203008176	203008176	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatcaatgagggggaccgcCtgggtccccctcatggcgcc	7	6	13	15	2	2	1	2	1	0	0	3	2	3	2	5	4	0	0	5	4	2	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:203008176C>T	uc009xaj.2	+	6	481	c.481C>T	c.(481-483)CTG>TTG	p.L161L				O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GGGGGACCGCCTGGGTCCCCC	0.622											OREG0014109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	11					0	0	0	0	T	203008176	T	T	203008176	2	4	239	1	0	0	0	0	0	0	0	1	12367	696	24	4		4	PPFIA4	1	203008176	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	720582	203008176	46242445	21	43654											
TMCC2	9911	broad.mit.edu	37	chr1	205238351	205238351	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgttcgagaagaagaacCagaagtcagcccagaccatc	16	5	10	10	1	1	5	1	0	0	5	3	6	1	5	3	0	2	1	3	0	5	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:205238351C>T	uc001hbz.1	+	4	1465	c.1021C>T	c.(1021-1023)CAG>TAG	p.Q341*	TMCC2_uc010prf.1_Nonsense_Mutation_p.Q263*|TMCC2_uc001hca.2_Nonsense_Mutation_p.Q116*|TMCC2_uc001hcb.1_Nonsense_Mutation_p.Q101*|TMCC2_uc001hcc.1_5'UTR|TMCC2_uc001hcd.2_Nonsense_Mutation_p.Q108*	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	341	Potential.					integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GAAGAAGAACCAGAAGTCAGC	0.592													4	45					0	0	0	0	T	205238351	T	T	205238351	4	4	239	1	0	0	0	0	0	1	0	0	16059	595	21	4	1031	4	TMCC2	1	205238351	Nonsense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	2230175	205238351	44012270	22	43655											
IL19	29949	broad.mit.edu	37	chr1	206972269	206972269	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggagcgtttccgcacagAtctgcgtgttccttaccact	7	11	11	12	3	1	1	0	0	1	1	3	3	3	2	3	1	3	3	3	1	1	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:206972269A>T	uc001heo.2	+	1	55	c.30A>T	c.(28-30)AGA>AGT	p.R10S		NM_153758	NP_715639	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 1 precursor	Error:Variant_position_missing_in_Q9UHD0_after_alignment					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			TTCCGCACAGATCTGCGTGTT	0.478													34	80					0	0	0	0	T	206972269	T	T	206972269	3	4	239	1	0	0	0	0	1	0	0	0	7688	330	12	5	32	5	IL19	1	206972269	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	1733918	206972269	42278352	23	43656											
LYST	1130	broad.mit.edu	37	chr1	235904812	235904812	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctttctctcttgtgcagcGtgggctggcgacaaaatatg	7	13	12	9	2	2	0	0	0	2	0	3	1	2	0	0	2	3	3	0	2	3	3	rs141534829	byFrequency	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:235904812G>A	uc001hxj.2	-	31	8443	c.8268C>T	c.(8266-8268)CAC>CAT	p.H2756H	LYST_uc009xga.1_Silent_p.H392H	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2756					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CTTGTGCAGCGTGGGCTGGCG	0.438									Chediak-Higashi_syndrome				6	94					0	0	0	0	A	235904812	A	A	235904812	2	1	239	1	0	0	0	0	0	0	0	1	9179	1136	40	1		1	LYST	1	235904812	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	28932543	235904812	13345809	24	43657											
HEATR1	55127	broad.mit.edu	37	chr1	236714247	236714247	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccaggacagtttccagttgCtgaatagtcttttggcactg	8	13	10	10	0	1	1	0	1	1	0	2	2	2	2	2	2	1	4	2	2	2	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:236714247C>T	uc001hyd.1	-	45	6515	c.6390G>A	c.(6388-6390)CAG>CAA	p.Q2130Q	HEATR1_uc009xgh.1_Silent_p.Q1292Q	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	2130	HEAT.				rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTTCCAGTTGCTGAATAGTCT	0.368													30	38					0	0	0	0	T	236714247	T	T	236714247	2	4	239	1	0	0	0	0	0	0	0	1	7066	796	28	4		4	HEATR1	1	236714247	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	809435	236714247	12536374	25	43658											
PXDN	7837	broad.mit.edu	37	chr2	1651956	1651956	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcaccttttcagtttcTcccggatctcagggttttta	6	16	7	12	1	4	0	3	0	2	0	6	1	4	1	2	2	1	3	2	2	1	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:1651956T>C	uc002qxa.2	-	17	3660	c.3596A>G	c.(3595-3597)GAG>GGG	p.E1199G		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1199					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TTTCAGTTTCTCCCGGATCTC	0.512													34	202					0	0	0	0	C	1651956	C	C	1651956	3	2	239	1	0	0	0	0	1	0	0	0	12912	1551	54	5	871	5	PXDN	2	1651956	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08		1651956	241547417	26	43659											
ROCK2	9475	broad.mit.edu	37	chr2	11367521	11367521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtatcacaatgtaccatgcCtgtctgcatgaacaggagag	12	10	10	9	0	2	2	1	1	1	1	2	3	2	2	2	1	4	3	2	1	4	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:11367521C>T	uc002rbd.1	-	6	1176	c.727G>A	c.(727-729)GGC>AGC	p.G243S		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	243	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TGTACCATGCCTGTCTGCATG	0.373													54	130					0	0	0	0	T	11367521	T	T	11367521	3	4	239	1	0	0	0	0	1	0	0	0	13583	681	24	4	3551	4	ROCK2	2	11367521	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	9715565	11367521	231831852	27	43660											
DNMT3A	1788	broad.mit.edu	37	chr2	25468197	25468197	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggctcccacaggagatgcaGatgtctggaaagcagaggga	13	5	15	8	0	1	3	0	0	1	3	2	6	2	5	1	4	2	3	1	4	1	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:25468197G>A	uc002rgc.2	-	13	1736	c.1479C>T	c.(1477-1479)ATC>ATT	p.I493I	DNMT3A_uc002rgd.2_Silent_p.I493I|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.I304I	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	493	GATA-type; atypical.|ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGATGCAGATGTCTGGAA	0.602			Mis|F|N|S		AML								34	36					0	0	0	0	A	25468197	A	A	25468197	2	1	239	1	0	0	0	0	0	0	0	1	4698	932	33	2		2	DNMT3A	2	25468197	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	14100676	25468197	217731176	28	43661											
RGPD4	285190	broad.mit.edu	37	chr2	108488441	108488441	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaatctgatgttactcaagaAgaagagagagatggacagta	17	8	12	4	0	2	5	1	1	1	4	2	9	2	6	0	1	1	2	0	1	6	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:108488441A>G	uc010ywk.1	+	20	4063	c.3981A>G	c.(3979-3981)GAA>GAG	p.E1327E	RGPD4_uc002tdu.2_Silent_p.E514E|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1327					intracellular transport		binding			skin(2)	2						TTACTCAAGAAGAAGAGAGAG	0.393													17	233					0	0	0	0	G	108488441	G	G	108488441	2	3	239	1	0	0	0	0	0	0	0	1	13353	69	3	5		5	RGPD4	2	108488441	Silent	SNP	A	TCGA-CV-7250-01A-11D-2012-08	83020244	108488441	134710932	29	43662											
MERTK	10461	broad.mit.edu	37	chr2	112786077	112786077	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcaatacacagttgctggAgagctctgagggcctggccc	8	8	13	12	1	2	2	1	1	1	1	2	3	2	2	2	3	3	3	2	3	2	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:112786077A>G	uc002thk.1	+	19	2758	c.2636A>G	c.(2635-2637)GAG>GGG	p.E879G	MERTK_uc002thl.1_Missense_Mutation_p.E703G	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	879	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						CAGTTGCTGGAGAGCTCTGAG	0.522													43	164					0	0	0	0	G	112786077	G	G	112786077	3	3	239	1	0	0	0	0	1	0	0	0	9532	304	11	5	2710	5	MERTK	2	112786077	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	4297636	112786077	130413296	30	43663											
SLC20A1	6574	broad.mit.edu	37	chr2	113417263	113417263	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaccaggataagcctgaaGtctctctcctcttccagttc	9	12	7	13	0	3	2	0	2	3	0	7	3	4	3	4	1	1	1	4	1	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:113417263G>A	uc002tib.2	+	8	1977	c.1531G>A	c.(1531-1533)GTC>ATC	p.V511I	SLC20A1_uc002tic.1_Missense_Mutation_p.V323I	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	511	Helical; (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						TAAGCCTGAAGTCTCTCTCCT	0.468													11	163					0	0	0	0	A	113417263	A	A	113417263	3	1	239	1	0	0	0	0	1	0	0	0	14503	1029	36	4	1557	4	SLC20A1	2	113417263	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	631186	113417263	129782110	31	43664											
IL1F6	27179	broad.mit.edu	37	chr2	113764229	113764229	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gacccttgagaaagacagagGgaaccccatctacctgggcc	12	5	11	13	0	1	3	0	1	1	3	1	6	1	4	5	2	2	0	5	2	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:113764229G>C	uc010yxr.1	+	3	179	c.179G>C	c.(178-180)GGG>GCG	p.G60A		NM_014440	NP_055255	Q9UHA7	IL36A_HUMAN	interleukin 1 family, member 6 (epsilon)	60					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding				0						AAAGACAGAGGGAACCCCATC	0.527													61	221					0	0	0	0	C	113764229	C	C	113764229	3	2	239	1	0	0	0	0	1	0	0	0	7693	1232	43	4	189	4	IL1F6	2	113764229	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	346966	113764229	129435144	32	43665											
EN1	2019	broad.mit.edu	37	chr2	119603946	119603946	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccatacgagaggctgctgCgagtcagttttgaccacggg	8	8	15	10	3	1	2	1	1	0	1	1	4	1	2	2	3	3	3	2	3	1	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:119603946C>T	uc002tlm.2	-	1	1814	c.798G>A	c.(796-798)TCG>TCA	p.S266S		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	266					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						GAGGCTGCTGCGAGTCAGTTT	0.637													5	14					0	0	0	0	T	119603946	T	T	119603946	2	4	239	1	0	0	0	0	0	0	0	1	5133	755	27	1		1	EN1	2	119603946	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	5839717	119603946	123595427	33	43666											
THSD7B	80731	broad.mit.edu	37	chr2	138414509	138414510	+	Frame_Shift_Ins	INS	-	A	A																															gaaccaagacagctgcccccINSaacaggttctagaaacacgc																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:138414509_138414510insA	uc002tva.1	+	22	4162_4163	c.4162_4163insA	c.(4162-4164)CAAfs	p.Q1388fs	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CAGCTGCCCCCAACAGGTTCTA	0.426													---	---	---								A	138414510	A	A	138414509	7	5	239	1	0	1	1	0	0	0	0	0	15946	595	21	0	4247	0	THSD7B	2	138414509	Frame_Shift_Ins	INS	-	TCGA-CV-7250-01A-11D-2012-08	18810563	138414509	104784864	34	43667											
ZEB2	9839	broad.mit.edu	37	chr2	145156077	145156077	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggaagagctgtgtataaagGtttggcactaaatgggttca	12	12	13	4	0	1	1	1	0	0	1	1	2	1	2	0	4	1	5	0	4	6	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:145156077G>A	uc002tvu.2	-	8	3157	c.2677C>T	c.(2677-2679)CCT>TCT	p.P893S	ZEB2_uc002tvv.2_Missense_Mutation_p.P887S|ZEB2_uc010zbm.1_Missense_Mutation_p.P864S|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.P922S	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	893						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GTGTATAAAGGTTTGGCACTA	0.438													9	177					0	0	0	0	A	145156077	A	A	145156077	3	1	239	1	0	0	0	0	1	0	0	0	17691	1261	44	4	979	4	ZEB2	2	145156077	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	6741568	145156077	98043296	35	43668											
NEB	4703	broad.mit.edu	37	chr2	152423805	152423805	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggtctgcccctgcttggcGgccaagactgacaccatatc	8	8	11	14	1	1	2	0	1	1	1	2	2	1	2	4	3	2	1	4	3	2	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:152423805G>A	uc010fnx.2	-	86	13121	c.12930C>T	c.(12928-12930)GCC>GCT	p.A4310A	NEB_uc002txr.2_Silent_p.A733A	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4310	Nebulin 118.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCTGCTTGGCGGCCAAGACTG	0.438													52	53					0	0	0	0	A	152423805	A	A	152423805	2	1	239	1	0	0	0	0	0	0	0	1	10356	1103	39	1		1	NEB	2	152423805	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	7267728	152423805	90775568	36	43669											
NEB	4703	broad.mit.edu	37	chr2	152483591	152483591	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactggtaaatttcagcttGtccggaggctggcggtagat	9	11	13	8	2	1	1	1	0	0	1	2	2	2	2	1	5	1	4	1	5	3	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:152483591G>C	uc010fnx.2	-	66	9734	c.9543C>G	c.(9541-9543)GAC>GAG	p.D3181E		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3181	Nebulin 86.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATTTCAGCTTGTCCGGAGGCT	0.488													9	111					0	0	0	0	C	152483591	C	C	152483591	3	2	239	1	0	0	0	0	1	0	0	0	10356	1368	48	4	15866	4	NEB	2	152483591	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	59786	152483591	90715782	37	43670											
COL3A1	1281	broad.mit.edu	37	chr2	189870100	189870100	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaagtgggaaaccaggagctAacggtctcagtggagaacgt	14	6	14	7	2	1	1	1	0	1	1	2	4	1	3	1	4	4	1	1	4	4	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:189870100A>T	uc002uqj.1	+	41	3073	c.2956A>T	c.(2956-2958)AAC>TAC	p.N986Y		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	986	Triple-helical region.			ANGLS -> PSGQN (in Ref. 20; AA sequence).	axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	ACCAGGAGCTAACGGTCTCAG	0.433													52	62					0	0	0	0	T	189870100	T	T	189870100	3	4	239	1	0	0	0	0	1	0	0	0	3703	362	13	5	3118	5	COL3A1	2	189870100	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	37386509	189870100	53329273	38	43671											
NRP2	8828	broad.mit.edu	37	chr2	206590770	206590770	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catggtgatgacaatggctgGacccccaacttggattccaa	11	9	10	11	0	0	2	0	2	0	0	1	4	1	4	3	4	1	1	3	4	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:206590770G>T	uc002vaw.2	+	6	1745	c.954G>T	c.(952-954)TGG>TGT	p.W318C	NRP2_uc002vat.2_Missense_Mutation_p.W318C|NRP2_uc002vau.2_Missense_Mutation_p.W318C|NRP2_uc002vav.2_Missense_Mutation_p.W318C|NRP2_uc002vax.2_Missense_Mutation_p.W318C|NRP2_uc002vay.2_Missense_Mutation_p.W318C|NRP2_uc010fud.2_Missense_Mutation_p.W318C	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	318	Extracellular (Potential).|F5/8 type C 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						ACAATGGCTGGACCCCCAACT	0.522													15	40					1.52009e-12	6.43803e-12	1	0	T	206590770	T	T	206590770	3	4	239	1	0	0	0	0	1	0	0	0	10715	1183	41	2	976	2	NRP2	2	206590770	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	16720670	206590770	36608603	39	43672											
IKZF2	22807	broad.mit.edu	37	chr2	213878608	213878608	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcaaaaggcaccagagaaaTattgttgtccataataggct	15	10	8	8	0	1	1	1	0	0	1	2	2	2	1	2	2	0	3	2	2	6	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:213878608T>C	uc002vem.2	-	7	932	c.763A>G	c.(763-765)ATT>GTT	p.I255V	IKZF2_uc010fuu.2_Missense_Mutation_p.I110V|IKZF2_uc002vej.2_Missense_Mutation_p.I202V|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Intron|IKZF2_uc002vel.2_Missense_Mutation_p.I176V|IKZF2_uc010fuw.2_Missense_Mutation_p.I29V|IKZF2_uc010fux.2_Missense_Mutation_p.I29V|IKZF2_uc010fuy.2_Missense_Mutation_p.I183V|IKZF2_uc002ven.2_Missense_Mutation_p.I229V|IKZF2_uc002vei.2_Missense_Mutation_p.I33V	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		ACCAGAGAAATATTGTTGTCC	0.388													38	70					0	0	0	0	C	213878608	C	C	213878608	3	2	239	1	0	0	0	0	1	0	0	0	7654	1406	49	5	825	5	IKZF2	2	213878608	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	7287838	213878608	29320765	40	43673											
SLC19A3	80704	broad.mit.edu	37	chr2	228560704	228560704	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatgcatgagaaataaagaaCcggcattgacaactgagaag	19	6	10	6	1	0	4	0	3	0	3	0	6	0	4	1	1	3	2	1	1	7	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:228560704C>T	uc002vpi.2	-	4	1162	c.1073G>A	c.(1072-1074)GGT>GAT	p.G358D	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.G354D	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	358	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	AAATAAAGAACCGGCATTGAC	0.468													29	86					0	0	0	0	T	228560704	T	T	228560704	3	4	239	1	0	0	0	0	1	0	0	0	14495	507	18	4	429	4	SLC19A3	2	228560704	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	14682096	228560704	14638669	41	43674											
ZNF385D	79750	broad.mit.edu	37	chr3	21706434	21706434	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtcaagaggaaagggaaGaaatggtttaatatccagcg	16	8	13	4	1	1	2	1	0	0	2	2	4	2	4	1	3	1	1	1	3	6	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:21706434G>T	uc003cce.2	-	2	517	c.109C>A	c.(109-111)CTT>ATT	p.L37I	ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	37						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GGAAAGGGAAGAAATGGTTTA	0.512													10	23					2.74318e-10	1.13325e-09	1	0	T	21706434	T	T	21706434	3	4	239	1	0	0	0	0	1	0	0	0	17945	942	33	2	1106	2	ZNF385D	3	21706434	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08		21706434	176315996	42	43675											
GLB1	2720	broad.mit.edu	37	chr3	33059966	33059966	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacagcaacatatgctcgatCgtggactccattgaggggtg	10	9	12	10	2	0	1	0	1	0	0	3	3	1	2	1	3	3	2	1	3	2	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:33059966C>T	uc003cfi.1	-	13	1438	c.1321G>A	c.(1321-1323)GAT>AAT	p.D441N	GLB1_uc003cfh.1_Missense_Mutation_p.D411N|GLB1_uc003cfj.1_Missense_Mutation_p.D310N|GLB1_uc011axk.1_Missense_Mutation_p.D489N	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	441			D -> N (in GM1G1).		carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				TATGCTCGATCGTGGACTCCA	0.507													16	70					0	0	0	0	T	33059966	T	T	33059966	3	4	239	1	0	0	0	0	1	0	0	0	6464	884	31	1	728	1	GLB1	3	33059966	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	11353532	33059966	164962464	43	43676											
ARPP21	10777	broad.mit.edu	37	chr3	35833960	35833960	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agagtcagaacgtgataaatAaccaacaaggaactccggtg	17	6	10	8	2	1	3	1	1	0	2	2	4	2	4	2	2	4	0	2	2	7	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:35833960A>T	uc003cgb.2	+	19	2383	c.2119A>T	c.(2119-2121)AAC>TAC	p.N707Y	ARPP21_uc003cga.2_Missense_Mutation_p.N688Y|ARPP21_uc011axy.1_Missense_Mutation_p.N708Y|ARPP21_uc003cgf.2_Missense_Mutation_p.N543Y|ARPP21_uc003cgg.2_Missense_Mutation_p.N230Y	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	707	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CGTGATAAATAACCAACAAGG	0.463													33	61					0	0	0	0	T	35833960	T	T	35833960	3	4	239	1	0	0	0	0	1	0	0	0	980	362	13	5	2198	5	ARPP21	3	35833960	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	2773994	35833960	162188470	44	43677											
EPM2AIP1	9852	broad.mit.edu	37	chr3	37033930	37033930	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acactgaaatgatgagtcagGttgattatggtcagaagatc	14	11	11	5	0	2	6	2	4	0	2	3	6	2	6	0	2	0	1	0	2	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:37033930G>A	uc003cgk.2	-	1	866	c.639C>T	c.(637-639)AAC>AAT	p.N213N	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	213						endoplasmic reticulum					0						GATGAGTCAGGTTGATTATGG	0.517													6	97					0	0	0	0	A	37033930	A	A	37033930	2	1	239	1	0	0	0	0	0	0	0	1	5208	1252	44	4		4	EPM2AIP1	3	37033930	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	1199970	37033930	160988500	45	43678											
CTNNB1	1499	broad.mit.edu	37	chr3	41267196	41267196	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgccattacaactctccaCaaccttttattacatcaaga	14	13	2	12	0	2	1	1	0	1	1	3	1	2	1	3	0	5	0	3	0	7	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:41267196C>T	uc010hia.1	+	7	936	c.780C>T	c.(778-780)CAC>CAT	p.H260H	CTNNB1_uc003ckp.2_Silent_p.H260H|CTNNB1_uc003ckq.2_Silent_p.H260H|CTNNB1_uc003ckr.2_Silent_p.H260H|CTNNB1_uc011azf.1_Silent_p.H253H|CTNNB1_uc011azg.1_Silent_p.H188H|uc010hib.1_5'Flank	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	260	ARM 3.			H->A: Abolishes or strongly reduces AXIN1 and AXIN2 binding. Strongly reduces phosphorylation and degradation; when associated with A-386 and A-383.	adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	CAACTCTCCACAACCTTTTAT	0.383		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				54	37					0	0	0	0	T	41267196	T	T	41267196	2	4	239	1	0	0	0	0	0	0	0	1	4033	477	17	4		4	CTNNB1	3	41267196	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	4233266	41267196	156755234	46	43679											
CDCP1	64866	broad.mit.edu	37	chr3	45127378	45127378	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtccacctctggctgcaGgaaggagccgctggaatcct	7	8	14	12	1	1	0	0	0	1	0	3	3	3	3	4	5	2	3	4	5	2	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:45127378G>A	uc003com.2	-	9	2398	c.2263C>T	c.(2263-2265)CTG>TTG	p.L755L		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	755	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TCTGGCTGCAGGAAGGAGCCG	0.577													71	41					0	0	0	0	A	45127378	A	A	45127378	2	1	239	1	0	0	0	0	0	0	0	1	3108	991	35	4		4	CDCP1	3	45127378	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	3860182	45127378	152895052	47	43680											
PBRM1	55193	broad.mit.edu	37	chr3	52637658	52637658	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagctgagtgccggtgaaagAagaatctctccatttttgca	11	12	10	8	1	1	4	0	2	1	2	3	4	2	4	2	1	3	2	2	1	4	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:52637658A>G	uc003des.2	-	17	2670	c.2658T>C	c.(2656-2658)CTT>CTC	p.L886L	PBRM1_uc003dex.2_Intron|PBRM1_uc003deq.2_Silent_p.L886L|PBRM1_uc003der.2_Silent_p.L854L|PBRM1_uc003det.2_Silent_p.L901L|PBRM1_uc003deu.2_Silent_p.L901L|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Silent_p.L886L|PBRM1_uc010hmk.1_Silent_p.L886L|PBRM1_uc003dey.2_Silent_p.L886L|PBRM1_uc003dez.1_Silent_p.L886L|PBRM1_uc003dfb.1_Silent_p.L799L|PBRM1_uc003dfa.1_Silent_p.L232L	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	886					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CCGGTGAAAGAAGAATCTCTC	0.343			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								9	29					0	0	0	0	G	52637658	G	G	52637658	2	3	239	1	0	0	0	0	0	0	0	1	11545	233	9	5		5	PBRM1	3	52637658	Silent	SNP	A	TCGA-CV-7250-01A-11D-2012-08	7510280	52637658	145384772	48	43681											
NEK4	6787	broad.mit.edu	37	chr3	52778296	52778297	+	Frame_Shift_Del	DEL	CT	-	-																															gtgactgctttagtcgcctcCtctctctggctgataatggt																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:52778296_52778297delCT	uc003dfq.3	-	11	2041_2042	c.1852_1853delAG	c.(1852-1854)AGGfs	p.R618fs	NEK4_uc011bej.1_Frame_Shift_Del_p.R529fs|NEK4_uc003dfr.2_Frame_Shift_Del_p.R572fs	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	618					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TAGTCGCCTCCTCTCTCTGGCT	0.406													---	---	---								-	52778297	-	-	52778296	7	5	239	1	0	1	0	1	0	0	0	0	10380	681	24	0	696	0	NEK4	3	52778296	Frame_Shift_Del	DEL	CT	TCGA-CV-7250-01A-11D-2012-08	140638	52778296	145244134	49	43682											
FAM55C	91775	broad.mit.edu	37	chr3	101535734	101535734	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagaaagtttaagatgcgtCagtttaatgaccctgacaac	14	10	8	9	1	1	4	1	2	0	2	1	4	1	4	2	0	2	2	2	0	4	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:101535734C>T	uc003dvn.2	+	7	1655	c.1018C>T	c.(1018-1020)CAG>TAG	p.Q340*	FAM55C_uc010hpn.2_Nonsense_Mutation_p.Q340*	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	340						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						TAAGATGCGTCAGTTTAATGA	0.393													7	92					0	0	0	0	T	101535734	T	T	101535734	4	4	239	1	0	0	0	0	0	1	0	0	5618	827	29	2	1032	2	FAM55C	3	101535734	Nonsense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	48757438	101535734	96486696	50	43683											
DZIP3	9666	broad.mit.edu	37	chr3	108353773	108353773	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtttatttccataaaatttGctggaaaaagttcaagaatt	15	16	6	4	0	1	1	1	0	0	1	2	2	2	2	1	1	1	3	1	1	7	7			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:108353773G>T	uc003dxd.2	+	10	1294	c.872G>T	c.(871-873)TGC>TTC	p.C291F	DZIP3_uc003dxf.1_Missense_Mutation_p.C291F|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Missense_Mutation_p.C291F|DZIP3_uc003dxg.1_Missense_Mutation_p.C14F	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	291					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CATAAAATTTGCTGGAAAAAG	0.264													17	60					3.51602e-12	1.48291e-11	1	0	T	108353773	T	T	108353773	3	4	239	1	0	0	0	0	1	0	0	0	4887	1319	46	4	906	4	DZIP3	3	108353773	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	6818039	108353773	89668657	51	43684											
PLXND1	23129	broad.mit.edu	37	chr3	129303021	129303021	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtcgtagatggtgaaattGgccttgacgatgttccgccc	8	11	12	10	3	0	3	0	2	0	1	2	4	1	3	3	2	0	2	3	2	2	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:129303021G>A	uc003emx.2	-	7	2185	c.2085C>T	c.(2083-2085)GCC>GCT	p.A695A		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	695	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGGTGAAATTGGCCTTGACGA	0.597													5	6					0	0	0	0	A	129303021	A	A	129303021	2	1	239	1	0	0	0	0	0	0	0	1	12182	1335	47	4		4	PLXND1	3	129303021	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	20949248	129303021	68719409	52	43685											
COL6A6	131873	broad.mit.edu	37	chr3	130380825	130380825	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaaacaactaaatggagatGcttttattggtcatgcctta	13	15	7	6	0	1	1	1	0	0	1	1	2	1	1	1	2	4	1	1	2	7	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:130380825G>T	uc010htl.2	+	34	6206	c.6175G>T	c.(6175-6177)GCT>TCT	p.A2059S	COL6A6_uc003eni.3_Missense_Mutation_p.A158S	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	2059	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AAATGGAGATGCTTTTATTGG	0.413													14	42					3.27435e-08	1.32552e-07	1	0	T	130380825	T	T	130380825	3	4	239	1	0	0	0	0	1	0	0	0	3718	1319	46	4	6309	4	COL6A6	3	130380825	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	1077804	130380825	67641605	53	43686											
MME	4311	broad.mit.edu	37	chr3	154834497	154834497	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aacctctactcaaactgttaCcagacatatatgggtggcca	13	10	7	11	0	2	1	1	0	1	1	2	1	2	1	3	2	4	1	3	2	6	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:154834497C>G	uc010hvr.1	+	6	695	c.484C>G	c.(484-486)CCA>GCA	p.P162A	MME_uc003fab.1_Missense_Mutation_p.P162A|MME_uc003fac.1_Missense_Mutation_p.P162A|MME_uc003fad.1_Missense_Mutation_p.P162A|MME_uc003fae.1_Missense_Mutation_p.P162A	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	162	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CAAACTGTTACCAGACATATA	0.363													7	45					0	0	0	0	G	154834497	G	G	154834497	3	3	239	1	0	0	0	0	1	0	0	0	9698	507	18	4	502	4	MME	3	154834497	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	24453672	154834497	43187933	54	43687											
SI	6476	broad.mit.edu	37	chr3	164727122	164727122	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaaagtccacaatttctctgGcccaccactctgctgtggaa	11	10	7	13	0	2	0	0	0	2	0	4	1	3	1	3	2	1	1	3	2	4	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:164727122G>T	uc003fei.2	-	35	4186	c.4124C>A	c.(4123-4125)GCC>GAC	p.A1375D		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1375	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AATTTCTCTGGCCCACCACTC	0.383										HNSCC(35;0.089)			18	57					1.45105e-14	6.22408e-14	1	0	T	164727122	T	T	164727122	3	4	239	1	0	0	0	0	1	0	0	0	14362	1203	42	4	1415	4	SI	3	164727122	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	9892625	164727122	33295308	55	43688											
SLC2A2	6514	broad.mit.edu	37	chr3	170723243	170723243	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctttggtgacatcatcatatCctctgagtcttttcaagcct	8	16	6	11	0	5	2	3	2	2	0	6	2	6	2	2	1	1	0	2	1	2	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:170723243C>T	uc003fhe.1	-	7	1103	c.794G>A	c.(793-795)GGA>GAA	p.G265E	SLC2A2_uc003fhf.1_Missense_Mutation_p.G92E|SLC2A2_uc011bpu.1_Missense_Mutation_p.G138E	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	265	Cytoplasmic (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			ATCATCATATCCTCTGAGTCT	0.343													26	58					0	0	0	0	T	170723243	T	T	170723243	3	4	239	1	0	0	0	0	1	0	0	0	14608	855	30	2	800	2	SLC2A2	3	170723243	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	5996121	170723243	27299187	56	43689											
GHSR	2693	broad.mit.edu	37	chr3	172165726	172165726	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacgaagatgaccagcttcaCccgccccttggtgaccacca	10	6	9	16	2	1	3	1	2	0	1	1	5	1	3	6	1	1	1	6	1	1	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:172165726C>T	uc003fib.1	-	1	478	c.478G>A	c.(478-480)GTG>ATG	p.V160M	GHSR_uc011bpv.1_Missense_Mutation_p.V160M	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	160	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			ACCAGCTTCACCCGCCCCTTG	0.652													6	53					0	0	0	0	T	172165726	T	T	172165726	3	4	239	1	0	0	0	0	1	0	0	0	6412	507	18	4	704	4	GHSR	3	172165726	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	1442483	172165726	25856704	57	43690											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			17	62					0	0	0	0	A	178936091	A	A	178936091	3	1	239	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	6770365	178936091	19086339	58	43691											
ATP13A4	84239	broad.mit.edu	37	chr3	193156328	193156328	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaaaggtgaggccacagatgCctcctgctctgataatgaga	12	8	12	9	0	1	4	0	3	1	2	2	6	2	4	3	2	2	1	3	2	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:193156328C>G	uc003ftd.2	-	23	2716	c.2608G>C	c.(2608-2610)GCA>CCA	p.A870P	ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	870	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GCCACAGATGCCTCCTGCTCT	0.443													25	30					0	0	0	0	G	193156328	G	G	193156328	3	3	239	1	0	0	0	0	1	0	0	0	1128	739	26	4	1014	4	ATP13A4	3	193156328	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	14220237	193156328	4866102	59	43692											
LGI2	55203	broad.mit.edu	37	chr4	25013978	25013978	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtaatgttgtcatagctccGgaaattcatttcaatgtggt	10	16	9	6	1	3	0	3	0	0	0	4	1	4	1	1	2	1	3	1	2	4	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:25013978G>A	uc003grf.2	-	7	898	c.799C>T	c.(799-801)CGG>TGG	p.R267W		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	267	EAR 2.					extracellular region					0		Breast(46;0.173)				TCATAGCTCCGGAAATTCATT	0.507													7	103					0	0	0	0	A	25013978	A	A	25013978	3	1	239	1	0	0	0	0	1	0	0	0	8793	1115	39	1	846	1	LGI2	4	25013978	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08		25013978	166140298	60	43693											
SULT1B1	27284	broad.mit.edu	37	chr4	70620403	70620403	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttacctgatgttcttaatcCagggagagtcatttccaaca	11	14	7	9	0	2	2	1	1	1	1	4	3	4	2	3	1	2	1	3	1	3	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:70620403C>A	uc003hen.2	-	3	560	c.262G>T	c.(262-264)GGA>TGA	p.G88*		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	88					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						GTTCTTAATCCAGGGAGAGTC	0.299													28	70					9.65021e-13	4.12178e-12	1	0	A	70620403	A	A	70620403	4	1	239	1	0	0	0	0	0	1	0	0	15442	603	21	4	652	4	SULT1B1	4	70620403	Nonsense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	45606425	70620403	120533873	61	43694											
PTPN13	5783	broad.mit.edu	37	chr4	87703369	87703369	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttcaggttcctacagtgtggGgtcttgcagccagcctgccc	5	11	12	13	0	2	0	1	0	1	0	3	0	3	0	4	3	5	2	4	3	1	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:87703369G>A	uc003hpz.2	+	37	6458	c.5978G>A	c.(5977-5979)GGG>GAG	p.G1993E	PTPN13_uc003hpy.2_Missense_Mutation_p.G1998E|PTPN13_uc003hqa.2_Missense_Mutation_p.G1974E|PTPN13_uc003hqb.2_Missense_Mutation_p.G1802E|PTPN13_uc003hqc.1_Missense_Mutation_p.G359E	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1993						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TACAGTGTGGGGTCTTGCAGC	0.443													9	85					0	0	0	0	A	87703369	A	A	87703369	3	1	239	1	0	0	0	0	1	0	0	0	12845	1232	43	4	6135	4	PTPN13	4	87703369	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	17082966	87703369	103450907	62	43695											
HSPA4L	22824	broad.mit.edu	37	chr4	128732697	128732697	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcttcagtgtggctagcgCatcagtaattgagaagcaaa	14	10	10	7	1	3	1	2	1	1	1	3	2	3	1	0	1	2	4	0	1	5	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:128732697C>T	uc003ifm.2	+	12	1737	c.1484C>T	c.(1483-1485)GCA>GTA	p.A495V	HSPA4L_uc010iny.1_Missense_Mutation_p.A454V|HSPA4L_uc011cgr.1_Missense_Mutation_p.A462V	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	495					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GTGGCTAGCGCATCAGTAATT	0.368													8	26					0	0	0	0	T	128732697	T	T	128732697	3	4	239	1	0	0	0	0	1	0	0	0	7452	710	25	4	1530	4	HSPA4L	4	128732697	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	41029328	128732697	62421579	63	43696											
NAA15	80155	broad.mit.edu	37	chr4	140309172	140309172	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgcctcctggatatgaagaGgatatgaagatcacagttaa	15	10	10	6	0	1	4	1	2	0	2	2	6	2	6	2	2	1	1	2	2	5	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:140309172G>A	uc003ihu.1	+	20	2791	c.2535G>A	c.(2533-2535)GAG>GAA	p.E845E		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	845					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						GATATGAAGAGGATATGAAGA	0.388													13	25					0	0	0	0	A	140309172	A	A	140309172	2	1	239	1	0	0	0	0	0	0	0	1	10171	991	35	4		4	NAA15	4	140309172	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	11576475	140309172	50845104	64	43697											
PDGFC	56034	broad.mit.edu	37	chr4	157689065	157689065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcggttctctttagttcttCccttatggacactgagaagt	8	16	8	9	1	2	1	0	1	2	1	5	3	3	2	1	2	0	2	1	2	3	6	rs141820181		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:157689065C>T	uc003iph.1	-	5	1272	c.781G>A	c.(781-783)GAA>AAA	p.E261K	PDGFC_uc003ipi.1_Missense_Mutation_p.E98K|PDGFC_uc011cis.1_Missense_Mutation_p.E98K|PDGFC_uc011cir.1_Missense_Mutation_p.E105K	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	261					central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity	p.E261K(1)		ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		TTTAGTTCTTCCCTTATGGAC	0.438													38	90					0	0	0	0	T	157689065	T	T	157689065	3	4	239	1	0	0	0	0	1	0	0	0	11713	864	30	2	264	2	PDGFC	4	157689065	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	17379893	157689065	33465211	65	43698											
ODZ3	55714	broad.mit.edu	37	chr4	183601503	183601503	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gggtccggattgttcaagagGtatgcaagttagattcttct	9	14	12	6	1	3	2	1	0	2	2	4	3	4	3	1	3	1	4	1	3	4	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:183601503G>A	uc003ivd.1	+	8	1676	c.1639_splice	c.e8+1	p.A547_splice	ODZ3_uc003ive.1_Splice_Site	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3						signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TGTTCAAGAGGTATGCAAGTT	0.443													8	19					0	0	0	0	A	183601503	A	A	183601503	5	1	239	1	0	0	0	0	0	0	1	0	10890	1275	44	4	1670	4	ODZ3	4	183601503	Splice_Site	SNP	G	TCGA-CV-7250-01A-11D-2012-08	25912438	183601503	7552773	66	43699											
ING2	3622	broad.mit.edu	37	chr4	184432021	184432021	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tataaaccaaaggggaaatgGtattgcccaaagtgcagggg	15	7	13	6	0	0	0	0	0	0	0	0	1	0	1	2	5	3	2	2	5	7	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:184432021G>C	uc003ivs.1	+	2	888	c.759G>C	c.(757-759)TGG>TGC	p.W253C	ING2_uc011ckk.1_Missense_Mutation_p.W213C	NM_001564	NP_001555	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	253	PHD-type.				chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding	p.W253C(1)		ovary(1)	1		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		AGGGGAAATGGTATTGCCCAA	0.388													4	30					0	0	0	0	C	184432021	C	C	184432021	3	2	239	1	0	0	0	0	1	0	0	0	7775	1270	44	4	765	4	ING2	4	184432021	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	830518	184432021	6722255	67	43700											
FAT1	2195	broad.mit.edu	37	chr4	187557355	187557355	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatggagtctggtggttgatGacttttgagggcgaccattg	7	14	15	5	1	1	3	0	3	1	0	1	5	1	4	1	4	0	1	1	4	1	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:187557355G>C	uc003izf.2	-	6	4195	c.4007C>G	c.(4006-4008)TCA>TGA	p.S1336*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1336	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGTGGTTGATGACTTTTGAGG	0.418										HNSCC(5;0.00058)			15	36					0	0	0	0	C	187557355	C	C	187557355	4	2	239	1	0	0	0	0	0	1	0	0	5721	1294	45	2	9847	2	FAT1	4	187557355	Nonsense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	3125334	187557355	3596921	68	43701											
TUBB4Q	56604	broad.mit.edu	37	chr4	190904367	190904367	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaacatatgtcatatagcgCttcgttatctatgcagaagg	12	12	10	7	2	2	1	1	0	1	1	3	2	2	2	0	2	3	3	0	2	7	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:190904367C>G	uc011clg.1	-	4	616	c.613G>C	c.(613-615)GCG>CCG	p.A205P		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	206					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		TCATATAGCGCTTCGTTATCT	0.542													5	67					0	0	0	0	G	190904367	G	G	190904367	3	3	239	1	0	0	0	0	1	0	0	0	16827	797	28	4	691	4	TUBB4Q	4	190904367	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	3347012	190904367	249909	69	43702											
CDH9	1007	broad.mit.edu	37	chr5	26903930	26903930	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggagaattaaattgatacGtacctataaattaagtaaga	19	11	7	4	1	0	3	0	1	0	2	0	4	0	3	1	1	2	2	1	1	10	8			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:26903930G>A	uc003jgs.1	-	6	984	c.815C>T	c.(814-816)ACG>ATG	p.T272M	CDH9_uc010iug.2_Missense_Mutation_p.T272M	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	272	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AAATTGATACGTACCTATAAA	0.318													7	28					0	0	0	0	A	26903930	A	A	26903930	3	1	239	1	0	0	0	0	1	0	0	0	3132	1145	40	1	1582	1	CDH9	5	26903930	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08		26903930	154011330	70	43703											
NAIP	4671	broad.mit.edu	37	chr5	70308342	70308342	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttatgtcgtacttggcaatgTtaccaacatccttgttcaaa	11	15	6	9	1	1	0	1	0	0	0	3	0	2	0	2	1	3	4	2	1	6	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:70308342T>C	uc003kar.1	-	4	1119	c.401A>G	c.(400-402)AAC>AGC	p.N134S	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Missense_Mutation_p.N134S|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein isoform	134					anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CTTGGCAATGTTACCAACATC	0.488													36	126					0	0	0	0	C	70308342	C	C	70308342	3	2	239	1	0	0	0	0	1	0	0	0	10200	1725	60	5	3866	5	NAIP	5	70308342	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	43404412	70308342	110606918	71	43704											
FCHO2	115548	broad.mit.edu	37	chr5	72313079	72313086	+	Frame_Shift_Del	DEL	TTGAAAGT	-	-																															taacatggctaatactacagTtgaaagtttgatacaaaaat																								rs143520046	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:72313079_72313086delTTGAAAGT	uc003kcl.2	+	8	856_863	c.740_747delTTGAAAGT	c.(739-747)GTTGAAAGTfs	p.V247fs	FCHO2_uc011csl.1_Frame_Shift_Del_p.V214fs|FCHO2_uc011csk.1_Frame_Shift_Del_p.V247fs|FCHO2_uc011csm.1_Frame_Shift_Del_p.V53fs	NM_138782	NP_620137	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2 isoform a	247_249										ovary(1)	1		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		AATACTACAGTTGAAAGTTTGATACAAA	0.293													---	---	---								-	72313086	-	-	72313079	7	5	239	1	0	1	0	1	0	0	0	0	5820	1725	60	0	770	0	FCHO2	5	72313079	Frame_Shift_Del	DEL	TTGAAAGT	TCGA-CV-7250-01A-11D-2012-08	2004737	72313079	108602181	72	43705											
NSA2	10412	broad.mit.edu	37	chr5	74064792	74064792	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgaattacaccgtaaacgcTatggataccgtttggattac	12	13	8	8	3	0	1	0	1	0	0	0	3	0	3	2	2	4	3	2	2	7	7			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:74064792T>A	uc003kdk.1	+	2	123	c.40T>A	c.(40-42)TAT>AAT	p.Y14N	GFM2_uc003kdh.1_5'Flank|GFM2_uc003kdi.1_5'Flank|GFM2_uc010izj.1_5'Flank|GFM2_uc010izk.1_5'Flank|GFM2_uc003kdj.1_5'Flank|GFM2_uc010izl.1_5'Flank	NM_014886	NP_055701	O95478	NSA2_HUMAN	NSA2 ribosome biogenesis homolog	14					rRNA processing	nucleolus|ribonucleoprotein complex				ovary(1)	1						CCGTAAACGCTATGGATACCG	0.328													5	9					0	0	0	0	A	74064792	A	A	74064792	3	1	239	1	0	0	0	0	1	0	0	0	10722	1522	53	5	46	5	NSA2	5	74064792	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	1751713	74064792	106850468	73	43706											
LIX1	167410	broad.mit.edu	37	chr5	96478236	96478236	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccggatctctgtgaggcaaGacttgggcaatgatgtgtct	8	11	14	8	1	2	3	0	2	2	1	3	4	2	4	1	3	0	2	1	3	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:96478236G>A	uc003kmy.3	-	1	285	c.45C>T	c.(43-45)GTC>GTT	p.V15V		NM_153234	NP_694966	Q8N485	LIX1_HUMAN	limb expression 1	15										ovary(1)	1		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		TGTGAGGCAAGACTTGGGCAA	0.453													6	55					0	0	0	0	A	96478236	A	A	96478236	2	1	239	1	0	0	0	0	0	0	0	1	8873	929	33	2		2	LIX1	5	96478236	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	22413444	96478236	84437024	74	43707											
PGGT1B	5229	broad.mit.edu	37	chr5	114588910	114588910	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaccacatctaaggaatcCaacatatccagcccggagag	14	7	7	13	1	2	1	1	0	1	1	4	3	4	2	4	2	2	0	4	2	4	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:114588910C>T	uc003kqw.3	-	2	204	c.183G>A	c.(181-183)TTG>TTA	p.L61L	PGGT1B_uc003kqx.3_5'UTR|PGGT1B_uc010jch.2_Silent_p.L61L	NM_005023	NP_005014	P53609	PGTB1_HUMAN	geranylgeranyltransferase type 1 beta	61					protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity				0		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)	CTAAGGAATCCAACATATCCA	0.363													11	50					0	0	0	0	T	114588910	T	T	114588910	2	4	239	1	0	0	0	0	0	0	0	1	11844	593	21	4		4	PGGT1B	5	114588910	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	18110674	114588910	66326350	75	43708											
ZNF608	57507	broad.mit.edu	37	chr5	123983042	123983042	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcaggggcaccgacctgcCcagggtgcatgtaacttgga	8	7	14	12	1	0	0	0	0	0	0	0	2	0	1	3	4	4	4	3	4	1	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:123983042C>A	uc003ktq.1	-	4	3158	c.3035G>T	c.(3034-3036)GGG>GTG	p.G1012V	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.G1012V|ZNF608_uc003ktt.1_Missense_Mutation_p.G1012V|ZNF608_uc003ktp.1_5'Flank	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1012						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		ACCGACCTGCCCAGGGTGCAT	0.473													46	94					8.20599e-20	3.69269e-19	1	0	A	123983042	A	A	123983042	3	1	239	1	0	0	0	0	1	0	0	0	18101	623	22	4	1527	4	ZNF608	5	123983042	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	9394132	123983042	56932218	76	43709											
SLC27A6	28965	broad.mit.edu	37	chr5	128351596	128351596	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagagaaggagaaaaggatCataaggtgcgtttggcaatt	16	8	14	3	1	1	3	1	0	0	3	1	6	1	4	0	4	1	2	0	4	5	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:128351596C>A	uc003kuy.2	+	6	1384	c.988C>A	c.(988-990)CAT>AAT	p.H330N	SLC27A6_uc003kuz.2_Missense_Mutation_p.H330N	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	330					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGAAAAGGATCATAAGGTGCG	0.308													11	30					3.86212e-05	0.000146906	1	0	A	128351596	A	A	128351596	3	1	239	1	0	0	0	0	1	0	0	0	14594	826	29	2	1006	2	SLC27A6	5	128351596	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	4368554	128351596	52563664	77	43710											
IL4	3565	broad.mit.edu	37	chr5	132015436	132015436	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agaaggaaaccttctgcaggGctgcgactgtgctccggcag	9	7	14	11	2	1	1	0	0	1	1	2	3	2	2	2	3	4	4	2	3	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:132015436G>A	uc003kxk.1	+	3	584	c.214G>A	c.(214-216)GCT>ACT	p.A72T	IL4_uc003kxl.1_Missense_Mutation_p.A56T	NM_000589	NP_000580	P05112	IL4_HUMAN	interleukin 4 isoform 1 precursor	72					B cell differentiation|cellular defense response|chemotaxis|cholesterol metabolic process|connective tissue growth factor biosynthetic process|negative regulation of apoptosis|negative regulation of osteoclast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of interleukin-13 production|positive regulation of isotype switching to IgE isotypes|positive regulation of isotype switching to IgG isotypes|positive regulation of MHC class II biosynthetic process|positive regulation of T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|T-helper 2 cell cytokine production	extracellular space	cytokine activity|growth factor activity|interleukin-4 receptor binding				0		all_cancers(142;2.81e-05)|all_lung(232;1.47e-05)|Lung NSC(810;2.31e-05)|all_neural(839;0.0459)|Ovarian(839;0.0481)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.00245)		CTTCTGCAGGGCTGCGACTGT	0.542													63	124					0	0	0	0	A	132015436	A	A	132015436	3	1	239	1	0	0	0	0	1	0	0	0	7735	1203	42	4	224	4	IL4	5	132015436	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	3663840	132015436	48899824	78	43711											
PCDHA5	56143	broad.mit.edu	37	chr5	140202653	140202653	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgcgcgggacgggggctcGccttcgctgtgggccaccgc	3	5	17	16	7	0	0	0	0	0	0	2	1	0	1	4	4	0	2	4	4	0	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:140202653G>A	uc003lhl.2	+	1	1293	c.1293G>A	c.(1291-1293)TCG>TCA	p.S431S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.S431S|PCDHA5_uc003lhj.1_Silent_p.S431S	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	431	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGGGGCTCGCCTTCGCTGT	0.647													12	150					0	0	0	0	A	140202653	A	A	140202653	2	1	239	1	0	0	0	0	0	0	0	1	11581	1074	38	1		1	PCDHA5	5	140202653	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	8187217	140202653	40712607	79	43712											
PCDHA8	56140	broad.mit.edu	37	chr5	140222342	140222342	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccacatcttcacggtgtctgCgcgagacgcggacgcgcagg	7	6	14	14	7	3	1	1	0	2	1	3	3	3	2	1	3	1	1	1	3	0	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:140222342C>T	uc003lhs.2	+	1	1436	c.1436C>T	c.(1435-1437)GCG>GTG	p.A479V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.A479V	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	479	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGTGTCTGCGCGAGACGCG	0.657													32	18					0	0	0	0	T	140222342	T	T	140222342	3	4	239	1	0	0	0	0	1	0	0	0	11584	768	27	1	1438	1	PCDHA8	5	140222342	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	19689	140222342	40692918	80	43713											
PCDHA13	56136	broad.mit.edu	37	chr5	140262926	140262926	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catcacttctttgtcactccCcatcagagaagacactcagc	11	10	5	15	0	5	2	4	0	1	2	6	3	6	2	2	0	1	0	2	0	1	2	rs144000682	byFrequency	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:140262926C>T	uc003lif.2	+	1	1073	c.1073C>T	c.(1072-1074)CCC>CTC	p.P358L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.P358L|PCDHA13_uc003lid.2_Missense_Mutation_p.P358L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	358	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTCACTCCCCATCAGAGAA	0.488													23	57					0	0	0	0	T	140262926	T	T	140262926	3	4	239	1	0	0	0	0	1	0	0	0	11577	623	22	4	1075	4	PCDHA13	5	140262926	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	40584	140262926	40652334	81	43714											
PCDHGB1	56104	broad.mit.edu	37	chr5	140731974	140731974	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcctgcgacgttcctccaGcctcgacactgagggctgct	5	8	12	16	4	0	1	0	1	0	0	3	3	2	1	4	1	3	3	4	1	0	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:140731974G>T	uc003ljo.1	+	1	2147	c.2147G>T	c.(2146-2148)AGC>ATC	p.S716I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA4_uc003ljq.1_5'Flank|PCDHGB1_uc011daq.1_Missense_Mutation_p.S716I|PCDHGA4_uc003ljp.1_5'Flank	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	716	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTTCCTCCAGCCTCGACACT	0.582													15	147					1.52009e-12	6.43803e-12	1	0	T	140731974	T	T	140731974	3	4	239	1	0	0	0	0	1	0	0	0	11616	971	34	4	2149	4	PCDHGB1	5	140731974	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	469048	140731974	40183286	82	43715											
FAM71B	153745	broad.mit.edu	37	chr5	156590090	156590090	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caaggtggagatgaggggtcCcactgctggtccttcagttc	7	10	14	10	0	1	2	1	1	0	1	4	3	3	2	2	5	1	2	2	5	1	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:156590090C>G	uc003lwn.2	-	2	1286	c.1186G>C	c.(1186-1188)GGA>CGA	p.G396R		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	396						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATGAGGGGTCCCACTGCTGGT	0.537													25	34					0	0	0	0	G	156590090	G	G	156590090	3	3	239	1	0	0	0	0	1	0	0	0	5640	632	22	4	635	4	FAM71B	5	156590090	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	15858116	156590090	24325170	83	43716											
GABRA6	2559	broad.mit.edu	37	chr5	161128536	161128536	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaatatcatctgaagaaaagGatcacttctctgtctttgcc	13	13	6	9	0	5	2	2	1	3	1	6	3	5	3	1	1	1	0	1	1	5	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:161128536G>A	uc003lyu.2	+	9	1457	c.1119G>A	c.(1117-1119)AGG>AGA	p.R373R	GABRA6_uc003lyv.2_Silent_p.R144R	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	373	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGAAGAAAAGGATCACTTCTC	0.398										TCGA Ovarian(5;0.080)			22	62					0	0	0	0	A	161128536	A	A	161128536	2	1	239	1	0	0	0	0	0	0	0	1	6199	1165	41	2		2	GABRA6	5	161128536	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	4538446	161128536	19786724	84	43717											
CDHR2	54825	broad.mit.edu	37	chr5	175995964	175995965	+	Frame_Shift_Del	DEL	CT	-	-																															ctctctggctgctgcagacaCtctacacattcaaagtcacc																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:175995964_175995965delCT	uc003mem.1	+	5	334_335	c.268_269delCT	c.(268-270)CTCfs	p.L90fs	CDHR2_uc003men.1_Frame_Shift_Del_p.L90fs	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	90	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GCTGCAGACACTCTACACATTC	0.644													---	---	---								-	175995965	-	-	175995964	7	5	239	1	0	1	0	1	0	0	0	0	3134	565	20	0	282	0	CDHR2	5	175995964	Frame_Shift_Del	DEL	CT	TCGA-CV-7250-01A-11D-2012-08	14867428	175995964	4919296	85	43718											
FGFR4	2264	broad.mit.edu	37	chr5	176517973	176517973	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacccccagcgcatggagaaGaaactgcatgcagtacctgc	12	5	10	14	1	0	2	0	0	0	2	0	3	0	2	3	1	6	4	3	1	3	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:176517973G>C	uc003mfl.2	+	5	638	c.471G>C	c.(469-471)AAG>AAC	p.K157N	FGFR4_uc003mfm.2_Missense_Mutation_p.K157N|FGFR4_uc011dfu.1_Missense_Mutation_p.K157N|FGFR4_uc011dfv.1_RNA|FGFR4_uc003mfn.1_3'UTR|FGFR4_uc011dfw.1_Missense_Mutation_p.K157N|FGFR4_uc003mfo.2_Missense_Mutation_p.K157N	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	157	Extracellular (Potential).|Ig-like C2-type 2.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GCATGGAGAAGAAACTGCATG	0.612										TSP Lung(9;0.080)			5	48					0	0	0	0	C	176517973	C	C	176517973	3	2	239	1	0	0	0	0	1	0	0	0	5900	933	33	2	485	2	FGFR4	5	176517973	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	522009	176517973	4397287	86	43719											
NSD1	64324	broad.mit.edu	37	chr5	176665392	176665392	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagggccccttggctcagtCagaacttggaggtggacatg	8	8	16	9	0	2	1	2	0	0	1	2	4	2	4	2	6	1	1	2	6	1	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:176665392C>A	uc003mfr.3	+	7	4214	c.4076C>A	c.(4075-4077)TCA>TAA	p.S1359*	NSD1_uc003mft.3_Nonsense_Mutation_p.S1090*|NSD1_uc003mfs.1_Nonsense_Mutation_p.S1256*|NSD1_uc011dfx.1_Nonsense_Mutation_p.S1007*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1359					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TTGGCTCAGTCAGAACTTGGA	0.542			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			78	34					1.03218e-28	4.68668e-28	1	0	A	176665392	A	A	176665392	4	1	239	1	0	0	0	0	0	1	0	0	10723	838	29	2	4098	2	NSD1	5	176665392	Nonsense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	147419	176665392	4249868	87	43720											
N4BP3	23138	broad.mit.edu	37	chr5	177548532	177548532	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcagctgcgtgaagcccagGcggaactggcccagaagctg	10	4	15	12	2	0	2	0	1	0	1	0	3	0	3	2	3	6	3	2	3	3	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:177548532G>A	uc003mik.1	+	5	1412	c.1165G>A	c.(1165-1167)GCG>ACG	p.A389T	N4BP3_uc003mil.1_Missense_Mutation_p.A58T	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	389	Potential.					cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGAAGCCCAGGCGGAACTGGC	0.622													47	90					0	0	0	0	A	177548532	A	A	177548532	3	1	239	1	0	0	0	0	1	0	0	0	10166	1203	42	4	1179	4	N4BP3	5	177548532	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	883140	177548532	3366728	88	43721											
GRM6	2916	broad.mit.edu	37	chr5	178424905	178424905	+	5'Flank	DEL	C	-	-																															cagctggcatagaggttgcaCcccaaaacccccgccctagc																								rs148398858	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:178424905delC	uc003mjr.2	-							NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor						detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AGAGGTTGCACCCCAAAACCC	0.542													---	---	---								-	178424905	-	-	178424905	6	5	239	0	1	1	0	1	0	0	0	0	6840	522	18	0		0	GRM6	5	178424905	5'Flank	DEL	C	TCGA-CV-7250-01A-11D-2012-08	876373	178424905	2490355	89	43722											
MGAT4B	11282	broad.mit.edu	37	chr5	179228834	179228837	+	Frame_Shift_Del	DEL	CTTT	-	-																															ctccgtctcgcagcgcctgcCtttctgacacggccctcttg																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:179228834_179228837delCTTT	uc003mks.2	-	2	599_602	c.230_233delAAAG	c.(229-234)GAAAGGfs	p.E77fs	MGAT4B_uc003mkp.2_5'Flank|MGAT4B_uc003mkq.2_5'UTR|MGAT4B_uc003mkr.2_Frame_Shift_Del_p.E92fs	NM_014275	NP_055090	Q9UQ53	MGT4B_HUMAN	alpha-1,3-mannosyl-glycoprotein	77_78	Potential.|Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding				0	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGCGCCTGCCTTTCTGACACGGC	0.667											OREG0017110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	179228837	-	-	179228834	7	5	239	1	0	1	0	1	0	0	0	0	9599	681	24	0	1469	0	MGAT4B	5	179228834	Frame_Shift_Del	DEL	CTTT	TCGA-CV-7250-01A-11D-2012-08	803929	179228834	1686426	90	43723											
HIST1H2BG	8339	broad.mit.edu	37	chr6	26216840	26216840	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccttcttggaacccttcttcGgagcaggagctgacttagct	7	12	10	12	1	2	1	0	1	2	0	3	4	2	4	2	3	4	3	2	3	2	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:26216840G>C	uc003ngz.2	-	1	33	c.32C>G	c.(31-33)CCG>CGG	p.P11R	HIST1H2AE_uc003nha.1_5'Flank	NM_003518	NP_003509	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	11					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				ACCCTTCTTCGGAGCAGGAGC	0.493													10	113					0	0	0	0	C	26216840	C	C	26216840	3	2	239	1	0	0	0	0	1	0	0	0	7185	1116	39	3	352	3	HIST1H2BG	6	26216840	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08		26216840	144898227	91	43724											
CDSN	1041	broad.mit.edu	37	chr6	31084822	31084822	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaagagctttgtccaggctgGgaagggtttagtattccgcg	8	11	15	7	2	0	1	0	0	0	1	2	3	2	2	2	3	1	4	2	3	4	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:31084822G>T	uc003nsm.1	-	2	597	c.570C>A	c.(568-570)TCC>TCA	p.S190S	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	190	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						GTCCAGGCTGGGAAGGGTTTA	0.557													38	36					3.62531e-18	1.59577e-17	1	0	T	31084822	T	T	31084822	2	4	239	1	0	0	0	0	0	0	0	1	3194	1219	43	4		4	CDSN	6	31084822	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	4867982	31084822	140030245	92	43725											
HSP90AB1	3326	broad.mit.edu	37	chr6	44217289	44217289	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgggaaccattgccaagtCtggtactaaagcattcatgg	11	12	10	8	0	2	0	1	0	1	0	2	1	2	1	2	3	4	2	2	3	5	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:44217289C>T	uc003oxa.1	+	3	407	c.323C>T	c.(322-324)TCT>TTT	p.S108F	HSP90AB1_uc011dvr.1_Missense_Mutation_p.S108F|HSP90AB1_uc003oxb.1_Missense_Mutation_p.S108F|HSP90AB1_uc011dvs.1_5'UTR|HSP90AB1_uc003oxc.1_5'Flank	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	108					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ATTGCCAAGTCTGGTACTAAA	0.418													9	59					0	0	0	0	T	44217289	T	T	44217289	3	4	239	1	0	0	0	0	1	0	0	0	7441	913	32	2	329	2	HSP90AB1	6	44217289	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	13132467	44217289	126897778	93	43726											
TINAG	27283	broad.mit.edu	37	chr6	54245333	54245333	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attaattgtagatggggcacActgagaggagcacaagggca	14	7	14	6	0	0	2	0	1	0	2	0	4	0	3	0	4	1	4	0	4	3	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:54245333A>T	uc003pcj.2	+	10	1406	c.1260A>T	c.(1258-1260)ACA>ACT	p.T420T	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	420					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			GATGGGGCACACTGAGAGGAG	0.358													4	11					0	0	0	0	T	54245333	T	T	54245333	2	4	239	1	0	0	0	0	0	0	0	1	15987	146	6	5		5	TINAG	6	54245333	Silent	SNP	A	TCGA-CV-7250-01A-11D-2012-08	10028044	54245333	116869734	94	43727											
LMBRD1	55788	broad.mit.edu	37	chr6	70428852	70428852	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaacatcaactcacttttGatttaatcgtttgaatgtgt	13	16	5	7	1	2	2	2	2	0	0	3	2	2	2	0	0	2	1	0	0	5	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:70428852G>C	uc003pfa.2	-	8	873	c.758C>G	c.(757-759)TCA>TGA	p.S253*	LMBRD1_uc003pey.2_Nonsense_Mutation_p.S49*|LMBRD1_uc003pez.2_Nonsense_Mutation_p.S180*|LMBRD1_uc010kal.2_Nonsense_Mutation_p.S180*|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	253	Cytoplasmic (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						ACTCACTTTTGATTTAATCGT	0.353													5	23					0	0	0	0	C	70428852	C	C	70428852	4	2	239	1	0	0	0	0	0	1	0	0	8884	1294	45	2	900	2	LMBRD1	6	70428852	Nonsense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	16183519	70428852	100686215	95	43728											
SENP6	26054	broad.mit.edu	37	chr6	76344481	76344481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagttcatggtagacgttttCatcatgctcatgcacagata	11	14	8	8	1	4	2	4	0	0	2	4	2	4	2	0	1	2	5	0	1	3	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:76344481C>T	uc003pid.3	+	5	1031	c.412C>T	c.(412-414)CAT>TAT	p.H138Y	SENP6_uc003pie.3_Missense_Mutation_p.H138Y|SENP6_uc003pic.2_Missense_Mutation_p.H138Y|SENP6_uc003pif.1_Missense_Mutation_p.H29Y	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	138					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				TAGACGTTTTCATCATGCTCA	0.353													14	32					0	0	0	0	T	76344481	T	T	76344481	3	4	239	1	0	0	0	0	1	0	0	0	14115	826	29	2	430	2	SENP6	6	76344481	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	5915629	76344481	94770586	96	43729											
MDN1	23195	broad.mit.edu	37	chr6	90384310	90384310	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacagctgaggaggttccTgtacagagaaacccatggga	13	6	12	10	0	0	2	0	1	0	1	1	5	1	4	2	3	3	3	2	3	2	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:90384310T>C	uc003pnn.1	-	79	12878	c.12762_splice	c.e79-1	p.R4254_splice		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGGAGGTTCCTGTACAGAGAA	0.507													13	32					0	0	0	0	C	90384310	C	C	90384310	5	2	239	1	0	0	0	0	0	0	1	0	9468	1594	55	5	4126	5	MDN1	6	90384310	Splice_Site	SNP	T	TCGA-CV-7250-01A-11D-2012-08	14039829	90384310	80730757	97	43730											
FUT9	10690	broad.mit.edu	37	chr6	96651512	96651512	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgactctgacttaccgccgtGattcagatatccaagtgcct	9	12	8	12	2	2	4	1	3	1	1	3	4	3	4	4	0	2	0	4	0	3	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:96651512G>T	uc003pop.3	+	3	822	c.481G>T	c.(481-483)GAT>TAT	p.D161Y		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	161	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		TTACCGCCGTGATTCAGATAT	0.453													19	35					1.1804e-14	5.08478e-14	1	0	T	96651512	T	T	96651512	3	4	239	1	0	0	0	0	1	0	0	0	6145	1290	45	2	483	2	FUT9	6	96651512	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	6267202	96651512	74463555	98	43731											
FAM184A	79632	broad.mit.edu	37	chr6	119338093	119338093	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatattcttgctgagttctcTttgcttcatttactttctaa	8	21	4	8	0	4	1	1	1	3	0	5	1	4	1	0	0	3	3	0	0	4	10			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:119338093T>C	uc003pyj.2	-	5	1697	c.1349A>G	c.(1348-1350)AAG>AGG	p.K450R	FAM184A_uc003pyk.3_Missense_Mutation_p.K330R|FAM184A_uc003pyl.3_Missense_Mutation_p.K330R	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	450	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						CTGAGTTCTCTTTGCTTCATT	0.333													11	35					0	0	0	0	C	119338093	C	C	119338093	3	2	239	1	0	0	0	0	1	0	0	0	5539	1609	56	5	2129	5	FAM184A	6	119338093	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	22686581	119338093	51776974	99	43732											
KIAA1244	57221	broad.mit.edu	37	chr6	138566721	138566721	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgagaagctgcaagccGccataaagtaagtgccctaa	13	8	11	9	1	0	1	0	1	0	1	0	2	0	1	3	0	4	3	3	0	6	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:138566721G>T	uc003qhu.2	+	8	658	c.658G>T	c.(658-660)GCC>TCC	p.A220S		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	220					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GCTGCAAGCCGCCATAAAGTA	0.453													5	14					1.23904e-05	4.82221e-05	1	0	T	138566721	T	T	138566721	3	4	239	1	0	0	0	0	1	0	0	0	8256	1087	38	3	688	3	KIAA1244	6	138566721	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	19228628	138566721	32548346	100	43733											
SYNE1	23345	broad.mit.edu	37	chr6	152462343	152462343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgctacgcactcaccagccGtttgggtttcggtactatgc	7	12	10	12	3	1	0	1	0	0	0	2	0	1	0	2	2	5	5	2	2	3	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:152462343G>A	uc010kiw.2	-	139	25843	c.25241C>T	c.(25240-25242)ACG>ATG	p.T8414M	SYNE1_uc010kiv.2_Missense_Mutation_p.T2938M|SYNE1_uc003qos.3_Missense_Mutation_p.T2938M|SYNE1_uc003qot.3_Missense_Mutation_p.T8366M|SYNE1_uc003qou.3_Missense_Mutation_p.T8414M|SYNE1_uc003qop.3_Missense_Mutation_p.T599M|SYNE1_uc011eez.1_Missense_Mutation_p.T616M|SYNE1_uc003qoq.3_Missense_Mutation_p.T616M|SYNE1_uc003qor.3_Missense_Mutation_p.T1337M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8414	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCACCAGCCGTTTGGGTTTC	0.478										HNSCC(10;0.0054)			28	60					0	0	0	0	A	152462343	A	A	152462343	3	1	239	1	0	0	0	0	1	0	0	0	15511	1145	40	1	1184	1	SYNE1	6	152462343	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	13895622	152462343	18652724	101	43734											
TIAM2	26230	broad.mit.edu	37	chr6	155458488	155458488	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgatcccctccggcagaacAtttatgagaatttcatgcga	11	10	9	11	3	1	2	1	1	0	2	3	5	3	2	3	1	2	1	3	1	3	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:155458488A>G	uc003qqb.2	+	7	2645	c.1372A>G	c.(1372-1374)ATT>GTT	p.I458V	TIAM2_uc003qqe.2_Missense_Mutation_p.I458V|TIAM2_uc010kjj.2_5'UTR	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	458					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CCGGCAGAACATTTATGAGAA	0.507													38	76					0	0	0	0	G	155458488	G	G	155458488	3	3	239	1	0	0	0	0	1	0	0	0	15957	217	8	5	1378	5	TIAM2	6	155458488	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	2996145	155458488	15656579	102	43735											
PLG	5340	broad.mit.edu	37	chr6	161159606	161159606	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtggaggcaccttgatatcCccagagtgggtgttgactgc	7	11	14	9	0	0	3	0	2	0	1	1	4	1	4	3	3	1	2	3	3	1	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:161159606C>T	uc003qtm.3	+	15	1902	c.1839C>T	c.(1837-1839)TCC>TCT	p.S613S		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	613	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CCTTGATATCCCCAGAGTGGG	0.373													30	60					0	0	0	0	T	161159606	T	T	161159606	2	4	239	1	0	0	0	0	0	0	0	1	12141	610	22	4		4	PLG	6	161159606	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	5701118	161159606	9955461	103	43736											
SDK1	221935	broad.mit.edu	37	chr7	4185403	4185403	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagcccccacaccttcacCaccgtggaggtcggcgccac	8	4	10	19	3	1	0	1	0	0	0	2	1	1	1	6	3	2	1	6	3	0	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:4185403C>A	uc003smx.2	+	29	4417	c.4278C>A	c.(4276-4278)ACC>ACA	p.T1426T	SDK1_uc010kso.2_Silent_p.T702T|SDK1_uc003smy.2_5'UTR	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1426	Fibronectin type-III 8.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACACCTTCACCACCGTGGAGG	0.657													9	60					1.76689e-08	7.18157e-08	1	0	A	4185403	A	A	4185403	2	1	239	1	0	0	0	0	0	0	0	1	14033	581	21	4		4	SDK1	7	4185403	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08		4185403	154953260	104	43737											
SCIN	85477	broad.mit.edu	37	chr7	12675756	12675756	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccttggaggacaggctgTgcaggttgggatatttttac	7	13	14	7	0	0	0	0	0	0	0	1	3	1	3	1	5	2	3	1	5	2	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:12675756T>C	uc003ssn.3	+	10	1616	c.1406T>C	c.(1405-1407)GTG>GCG	p.V469A	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Missense_Mutation_p.V222A	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	469	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		GGACAGGCTGTGCAGGTTGGG	0.468													4	8					0	0	0	0	C	12675756	C	C	12675756	3	2	239	1	0	0	0	0	1	0	0	0	13970	1696	59	5	1444	5	SCIN	7	12675756	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	8490353	12675756	146462907	105	43738											
ADCYAP1R1	117	broad.mit.edu	37	chr7	31124410	31124410	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctacagcacatccctcgTcaccctcaccactgccatgg	8	8	7	18	1	2	0	2	0	0	0	4	0	3	0	4	2	3	2	4	2	1	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:31124410T>A	uc003tca.1	+	8	720	c.497T>A	c.(496-498)GTC>GAC	p.V166D	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.V145D|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.V166D|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.V166D|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.V166D|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	166	Helical; Name=1; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity	p.V166fs*25(1)		ovary(1)	1						ACATCCCTCGTCACCCTCACC	0.557													30	79					0	0	0	0	A	31124410	A	A	31124410	3	1	239	1	0	0	0	0	1	0	0	0	303	1667	58	5	523	5	ADCYAP1R1	7	31124410	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	18448654	31124410	128014253	106	43739											
GRB10	2887	broad.mit.edu	37	chr7	50682481	50682481	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtacctttatgcagagccCgtggtctgtaggggcgttgt	5	12	16	8	2	1	1	0	0	1	1	1	1	1	1	2	4	3	4	2	4	3	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:50682481C>A	uc003tpi.2	-	9	1112	c.1081G>T	c.(1081-1083)GGG>TGG	p.G361W	GRB10_uc003tph.3_Missense_Mutation_p.G303W|GRB10_uc003tpj.2_Missense_Mutation_p.G315W|GRB10_uc003tpk.2_Missense_Mutation_p.G361W|GRB10_uc010kzb.2_Missense_Mutation_p.G303W|GRB10_uc003tpl.2_Missense_Mutation_p.G355W|GRB10_uc003tpm.2_Missense_Mutation_p.G303W|GRB10_uc003tpn.2_Missense_Mutation_p.G303W	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	361	PH.				insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					ATGCAGAGCCCGTGGTCTGTA	0.587									Russell-Silver_syndrome				31	68					8.16721e-17	3.54851e-16	1	0	A	50682481	A	A	50682481	3	1	239	1	0	0	0	0	1	0	0	0	6795	652	23	3	735	3	GRB10	7	50682481	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	19558071	50682481	108456182	107	43740											
EGFR	1956	broad.mit.edu	37	chr7	55220295	55220295	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccgtggcaagtcccccAgtgactgctgccacaaccag	8	6	11	16	1	0	1	0	1	0	0	1	1	1	1	5	1	4	3	5	1	2	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:55220295A>T	uc003tqk.2	+	6	931	c.685A>T	c.(685-687)AGT>TGT	p.S229C	EGFR_uc003tqh.2_Missense_Mutation_p.S229C|EGFR_uc003tqi.2_Missense_Mutation_p.S229C|EGFR_uc003tqj.2_Missense_Mutation_p.S229C|EGFR_uc010kzg.1_Missense_Mutation_p.S184C|EGFR_uc011kco.1_Missense_Mutation_p.S176C|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	229	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAAGTCCCCCAGTGACTGCTG	0.617		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			56	85					0	0	0	0	T	55220295	T	T	55220295	3	4	239	1	0	0	0	0	1	0	0	0	4989	188	7	5	707	5	EGFR	7	55220295	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	4537814	55220295	103918368	108	43741											
GRM3	2913	broad.mit.edu	37	chr7	86394583	86394583	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatagaaggtgaccttgtttTagggggcctgtttcctatta	9	15	11	6	0	0	2	0	1	0	1	1	2	1	2	3	3	0	2	3	3	6	7			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:86394583T>C	uc003uid.2	+	2	1221	c.122T>C	c.(121-123)TTA>TCA	p.L41S	GRM3_uc010lef.2_Missense_Mutation_p.L39S|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	41	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GACCTTGTTTTAGGGGGCCTG	0.413													23	48					0	0	0	0	C	86394583	C	C	86394583	3	2	239	1	0	0	0	0	1	0	0	0	6837	1764	61	5	124	5	GRM3	7	86394583	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	31174288	86394583	72744080	109	43742											
PON2	5445	broad.mit.edu	37	chr7	95039308	95039308	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtaaacaacatttgcccaGtgtaagttcaagtatgtttc	13	14	7	7	0	1	0	1	0	0	0	2	0	1	0	1	0	3	5	1	0	7	7			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:95039308G>A	uc003unv.2	-	6	721	c.600C>T	c.(598-600)CAC>CAT	p.H200H	PON2_uc003unu.2_Silent_p.H188H|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Silent_p.H113H	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	200					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			CATTTGCCCAGTGTAAGTTCA	0.373													23	54					0	0	0	0	A	95039308	A	A	95039308	2	1	239	1	0	0	0	0	0	0	0	1	12304	1020	36	4		4	PON2	7	95039308	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	8644725	95039308	64099355	110	43743											
TMEM168	64418	broad.mit.edu	37	chr7	112407741	112407741	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataataagccgggaacaaaaGgaaccattcttttctctcca	15	10	6	10	1	2	0	0	0	2	0	4	2	3	2	3	2	3	0	3	2	6	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:112407741G>C	uc003vgn.2	-	5	1997	c.1605C>G	c.(1603-1605)TCC>TCG	p.S535S	TMEM168_uc010lju.2_Silent_p.S535S|TMEM168_uc011kmr.1_Silent_p.S151S	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	535						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						GGGAACAAAAGGAACCATTCT	0.403													17	41					0	0	0	0	C	112407741	C	C	112407741	2	2	239	1	0	0	0	0	0	0	0	1	16149	987	35	4		4	TMEM168	7	112407741	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	17368433	112407741	46730922	111	43744											
PPP1R3A	5506	broad.mit.edu	37	chr7	113518983	113518983	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accagcttctgctttctcagTaatgccatgatcagctagag	10	12	8	11	0	3	2	2	1	2	1	4	2	3	2	2	0	4	4	2	0	2	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:113518983T>C	uc010ljy.1	-	4	2195	c.2164A>G	c.(2164-2166)ACT>GCT	p.T722A		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	722					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GCTTTCTCAGTAATGCCATGA	0.388													3	139					0	0	0	0	C	113518983	C	C	113518983	3	2	239	1	0	0	0	0	1	0	0	0	12431	1638	57	5	1208	5	PPP1R3A	7	113518983	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	1111242	113518983	45619680	112	43745											
DPP6	1804	broad.mit.edu	37	chr7	154172062	154172062	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcaaaagaagaaggtcactGtagaagatctcttcagtgaa	16	9	9	7	0	4	5	3	1	1	4	5	5	4	5	0	1	0	1	0	1	7	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:154172062G>C	uc003wlk.2	+	3	526	c.397G>C	c.(397-399)GTA>CTA	p.V133L	DPP6_uc003wli.2_Missense_Mutation_p.V69L|DPP6_uc003wlj.2_Missense_Mutation_p.V133L|DPP6_uc010lqh.1_Missense_Mutation_p.V71L|DPP6_uc003wlm.2_Missense_Mutation_p.V71L|DPP6_uc011kvq.1_Missense_Mutation_p.V71L	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	133	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GAAGGTCACTGTAGAAGATCT	0.403													39	44					0	0	0	0	C	154172062	C	C	154172062	3	2	239	1	0	0	0	0	1	0	0	0	4752	1377	48	4	523	4	DPP6	7	154172062	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	40653079	154172062	4966601	113	43746											
NCAPG2	54892	broad.mit.edu	37	chr7	158449250	158449250	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgtcaacctaccttggcCtgggcatgctctgtgggcag	6	11	13	11	0	2	1	1	1	1	0	2	1	2	1	3	3	3	3	3	3	2	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:158449250C>T	uc003wnv.1	-	18	2353	c.2208G>A	c.(2206-2208)CAG>CAA	p.Q736Q	NCAPG2_uc010lqu.1_Silent_p.Q528Q|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Silent_p.Q736Q|NCAPG2_uc011kwe.1_Silent_p.Q736Q|NCAPG2_uc011kwc.1_Silent_p.Q237Q|NCAPG2_uc011kwd.1_Silent_p.Q179Q	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	736					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		CTACCTTGGCCTGGGCATGCT	0.468													7	55					0	0	0	0	T	158449250	T	T	158449250	2	4	239	1	0	0	0	0	0	0	0	1	10262	680	24	4		4	NCAPG2	7	158449250	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	4277188	158449250	689413	114	43747											
MTUS1	57509	broad.mit.edu	37	chr8	17611496	17611496	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttcctgattcgatttcacGgcagatgttgttcttggaac	7	16	9	9	2	3	2	1	1	2	1	5	4	4	3	1	2	1	3	1	2	1	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:17611496G>C	uc003wxv.2	-	2	2295	c.1821C>G	c.(1819-1821)GCC>GCG	p.A607A	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Silent_p.A607A|MTUS1_uc010lsz.2_Silent_p.A607A	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	607						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		TCGATTTCACGGCAGATGTTG	0.433													5	167					0	0	0	0	C	17611496	C	C	17611496	2	2	239	1	0	0	0	0	0	0	0	1	10018	1103	39	3		3	MTUS1	8	17611496	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08		17611496	128752526	115	43748											
JPH1	56704	broad.mit.edu	37	chr8	75227563	75227563	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagacttggattcggacttGcgaagtttcatgcttccaag	10	12	11	8	2	1	1	1	0	0	1	3	5	2	3	1	2	2	2	1	2	3	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:75227563G>C	uc003yae.2	-	2	712	c.672C>G	c.(670-672)CGC>CGG	p.R224R	JPH1_uc003yaf.2_Silent_p.R224R|JPH1_uc003yag.1_Silent_p.R88R	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	224	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			ATTCGGACTTGCGAAGTTTCA	0.582													9	104					0	0	0	0	C	75227563	C	C	75227563	2	2	239	1	0	0	0	0	0	0	0	1	7999	1306	46	4		4	JPH1	8	75227563	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	57616067	75227563	71136459	116	43749											
RSPO2	340419	broad.mit.edu	37	chr8	108970481	108970481	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccccattcgctccaatgaCcaacttcacatccttctagt	9	13	3	16	1	2	1	1	1	1	0	6	1	5	1	5	0	1	1	5	0	3	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:108970481C>A	uc003yms.2	-	5	1101	c.443G>T	c.(442-444)GGT>GTT	p.G148V	RSPO2_uc003ymq.2_Missense_Mutation_p.G81V|RSPO2_uc003ymr.2_Missense_Mutation_p.G84V	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	148	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding	p.G148S(1)		skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			GCTCCAATGACCAACTTCACA	0.368													20	41					1.50039e-11	6.27549e-11	1	0	A	108970481	A	A	108970481	3	1	239	1	0	0	0	0	1	0	0	0	13775	507	18	4	296	4	RSPO2	8	108970481	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	33742918	108970481	37393541	117	43750											
CSMD3	114788	broad.mit.edu	37	chr8	113326782	113326782	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagatttgggtaactgtcAggatatccagggctcaatat	12	12	11	6	0	2	2	2	1	0	1	3	3	3	3	1	3	1	2	1	3	5	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:113326782A>T	uc003ynu.2	-	48	7584	c.7425T>A	c.(7423-7425)CCT>CCA	p.P2475P	CSMD3_uc003yns.2_Silent_p.P1677P|CSMD3_uc003ynt.2_Silent_p.P2435P|CSMD3_uc011lhx.1_Silent_p.P2371P|CSMD3_uc003ynw.1_Silent_p.P186P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2475	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTAACTGTCAGGATATCCAG	0.388										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	23					0	0	0	0	T	113326782	T	T	113326782	2	4	239	1	0	0	0	0	0	0	0	1	3963	175	7	5		5	CSMD3	8	113326782	Silent	SNP	A	TCGA-CV-7250-01A-11D-2012-08	4356301	113326782	33037240	118	43751											
FAM83H	286077	broad.mit.edu	37	chr8	144808544	144808544	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggttgctgctgtacaaggcGttggccgtggctgaggacag	7	9	17	8	2	0	1	0	1	0	0	0	2	0	2	1	5	3	6	1	5	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:144808544G>A	uc003yzk.2	-	5	3156	c.3087C>T	c.(3085-3087)AAC>AAT	p.N1029N	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	1029					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TGTACAAGGCGTTGGCCGTGG	0.692													5	10					0	0	0	0	A	144808544	A	A	144808544	2	1	239	1	0	0	0	0	0	0	0	1	5672	1136	40	1		1	FAM83H	8	144808544	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	31481762	144808544	1555478	119	43752											
PARP10	84875	broad.mit.edu	37	chr8	145060329	145060329	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaaagtagagagtgagcagCtcgtcgggcacggcaggggg	10	5	18	8	3	1	2	1	1	0	1	3	3	1	2	0	4	2	5	0	4	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:145060329C>T	uc003zal.3	-	2	183	c.75G>A	c.(73-75)GAG>GAA	p.E25E	PARP10_uc003zak.3_5'Flank|PARP10_uc011lku.1_Silent_p.E37E|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Silent_p.E25E|PARP10_uc010mfn.1_Silent_p.E25E|PARP10_uc010mfo.1_Intron	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	25						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAGTGAGCAGCTCGTCGGGCA	0.657													12	63					0	0	0	0	T	145060329	T	T	145060329	2	4	239	1	0	0	0	0	0	0	0	1	11509	796	28	4		4	PARP10	8	145060329	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	251785	145060329	1303693	120	43753											
LRRC14	9684	broad.mit.edu	37	chr8	145746352	145746352	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtgctctgctgcctgaGgacctacgcttcctggcacg	4	12	11	14	2	2	1	0	1	2	0	3	2	3	2	3	2	4	4	3	2	1	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:145746352G>A	uc003zdk.1	+	4	1118	c.972G>A	c.(970-972)GAG>GAA	p.E324E	LRRC14_uc003zdl.1_Silent_p.E324E|LRRC14_uc003zdo.2_5'Flank	NM_014665	NP_055480	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	324	LRR 2.										0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGCTGCCTGAGGACCTACGCT	0.637													18	159					0	0	0	0	A	145746352	A	A	145746352	2	1	239	1	0	0	0	0	0	0	0	1	9018	991	35	4		4	LRRC14	8	145746352	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	686023	145746352	617670	121	43754											
SMARCA2	6595	broad.mit.edu	37	chr9	2076291	2076291	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atactcctggatccaaatagCgaagaagtttctgagaagga	15	9	10	7	1	1	2	0	1	1	2	3	6	3	4	2	2	2	1	2	2	6	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:2076291C>A	uc003zhc.2	+	13	2097	c.1998C>A	c.(1996-1998)AGC>AGA	p.S666R	SMARCA2_uc003zhd.2_Missense_Mutation_p.S666R|SMARCA2_uc010mha.2_Missense_Mutation_p.S657R	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	666					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATCCAAATAGCGAAGAAGTTT	0.388													27	51					1.88708e-17	8.23455e-17	1	0	A	2076291	A	A	2076291	3	1	239	1	0	0	0	0	1	0	0	0	14833	767	27	3	2044	3	SMARCA2	9	2076291	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08		2076291	139137140	122	43755											
TEK	7010	broad.mit.edu	37	chr9	27218815	27218815	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgggagattgttagcttaGgtgagtatctatgtttatct	9	18	11	3	0	2	2	0	1	2	1	2	3	2	2	0	2	1	4	0	2	6	8			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:27218815G>T	uc003zqi.3	+	20	3545	c.3103G>T	c.(3103-3105)GGA>TGA	p.G1035*	TEK_uc011lno.1_Nonsense_Mutation_p.G992*|TEK_uc011lnp.1_Nonsense_Mutation_p.G887*	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	1035	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TGTTAGCTTAGGTGAGTATCT	0.463													13	32					6.72482e-11	2.78956e-10	1	0	T	27218815	T	T	27218815	4	4	239	1	0	0	0	0	0	1	0	0	15817	1014	35	4	3181	4	TEK	9	27218815	Nonsense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	25142524	27218815	113994616	123	43756											
CCIN	881	broad.mit.edu	37	chr9	36170744	36170744	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagcatccccatggatggCaccgccgtgatcactaaagg	11	7	11	12	2	1	2	1	2	0	0	2	3	2	3	4	3	1	2	4	3	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:36170744C>T	uc003zzb.3	+	1	1356	c.1245C>T	c.(1243-1245)GGC>GGT	p.G415G		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	415	Kelch 3.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			CCATGGATGGCACCGCCGTGA	0.542													29	43					0	0	0	0	T	36170744	T	T	36170744	2	4	239	1	0	0	0	0	0	0	0	1	2891	697	25	4		4	CCIN	9	36170744	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	8951929	36170744	105042687	124	43757											
TLE4	7091	broad.mit.edu	37	chr9	82320843	82320843	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgatgacaacttggtggttGacgtttccaatgaggtatgt	9	14	13	5	1	0	4	0	4	0	0	1	4	1	4	1	3	1	3	1	3	3	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:82320843G>C	uc004ald.2	+	10	1597	c.748G>C	c.(748-750)GAC>CAC	p.D250H	TLE4_uc004alc.2_Missense_Mutation_p.D257H|TLE4_uc010mpr.2_Missense_Mutation_p.D136H|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Missense_Mutation_p.D225H|TLE4_uc010mps.2_Intron|TLE4_uc004alf.2_Missense_Mutation_p.D196H	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CTTGGTGGTTGACGTTTCCAA	0.398													6	80					0	0	0	0	C	82320843	C	C	82320843	3	2	239	1	0	0	0	0	1	0	0	0	16007	1290	45	2	807	2	TLE4	9	82320843	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	46150099	82320843	58892588	125	43758											
GRIN3A	116443	broad.mit.edu	37	chr9	104449192	104449192	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgccggatactttccatgtcGcagccaaacatcaccactgt	10	9	7	15	3	1	0	1	0	0	0	3	1	2	1	4	1	3	1	4	1	2	2	rs144389302		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:104449192G>A	uc004bbp.1	-	2	1591	c.990C>T	c.(988-990)TGC>TGT	p.C330C	GRIN3A_uc004bbq.1_Silent_p.C330C	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	330	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TTTCCATGTCGCAGCCAAACA	0.527													11	26					0	0	0	0	A	104449192	A	A	104449192	2	1	239	1	0	0	0	0	0	0	0	1	6822	1079	38	1		1	GRIN3A	9	104449192	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	22128349	104449192	36764239	126	43759											
SETX	23064	broad.mit.edu	37	chr9	135204921	135204921	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttttactactctgctttaaGcatgacccagctaagagatg	11	14	7	9	0	1	2	0	1	1	1	1	3	1	2	1	0	5	3	1	0	4	7			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:135204921G>A	uc004cbk.2	-	10	2247	c.2064C>T	c.(2062-2064)TGC>TGT	p.C688C	SETX_uc004cbj.2_Silent_p.C307C|SETX_uc010mzt.2_Silent_p.C307C	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	688					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCTGCTTTAAGCATGACCCAG	0.328													25	43					0	0	0	0	A	135204921	A	A	135204921	2	1	239	1	0	0	0	0	0	0	0	1	14206	963	34	4		4	SETX	9	135204921	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	30755729	135204921	6008510	127	43760											
RALGDS	5900	broad.mit.edu	37	chr9	136037789	136037789	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagacccagggccagtctcCggcgatgcattgctgggggc	6	6	15	14	2	1	1	0	0	1	1	2	2	1	1	4	4	2	2	4	4	0	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:136037789C>T	uc011mcw.1	-	2	292	c.11G>A	c.(10-12)CGG>CAG	p.R4Q	GBGT1_uc004ccx.2_5'UTR|GBGT1_uc010nab.2_Missense_Mutation_p.R4Q|GBGT1_uc011mcx.1_Missense_Mutation_p.R4Q|GBGT1_uc004ccw.2_Missense_Mutation_p.R4Q|GBGT1_uc010nac.1_5'UTR|GBGT1_uc004ccy.1_Missense_Mutation_p.R4Q	NM_001042368	NP_001035827	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	Error:Variant_position_missing_in_Q12967_after_alignment					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		GGCCAGTCTCCGGCGATGCAT	0.607			T	CIITA	PMBL|Hodgkin Lymphona|								5	15					0	0	0	0	T	136037789	T	T	136037789	3	4	239	1	0	0	0	0	1	0	0	0	13081	652	23	1		1	RALGDS	9	136037789	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	832868	136037789	5175642	128	43761											
SURF4	6836	broad.mit.edu	37	chr9	136234223	136234223	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgatgtagtcgcgctgctcGctccactggaaccacatacg	8	9	10	14	5	0	0	0	0	0	0	4	2	1	1	2	1	3	4	2	1	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:136234223G>A	uc004cdj.2	-	2	277	c.147C>T	c.(145-147)AGC>AGT	p.S49S	SURF4_uc011mda.1_Silent_p.S40S|SURF4_uc010nal.2_Silent_p.S81S|SURF4_uc011mdb.1_Silent_p.S6S|SURF4_uc011mdc.1_Silent_p.S6S|SURF4_uc011mdd.1_Silent_p.S49S	NM_033161	NP_149351	O15260	SURF4_HUMAN	surfeit 4	49						endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		CGCGCTGCTCGCTCCACTGGA	0.597													22	25					0	0	0	0	A	136234223	A	A	136234223	2	1	239	1	0	0	0	0	0	0	0	1	15471	1078	38	1		1	SURF4	9	136234223	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	196434	136234223	4979208	129	43762											
FCN1	2219	broad.mit.edu	37	chr9	137809628	137809628	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctcacctggacatgtgtcCgcagcctgggcaggcaggtt	6	9	14	12	1	1	0	1	0	1	0	3	1	2	1	3	4	1	4	3	4	0	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:137809628C>T	uc004cfi.2	-	1	182	c.90G>A	c.(88-90)GCG>GCA	p.A30A		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	30					opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		GACATGTGTCCGCAGCCTGGG	0.572													23	42					0	0	0	0	T	137809628	T	T	137809628	2	4	239	1	0	0	0	0	0	0	0	1	5823	639	23	1		1	FCN1	9	137809628	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	1575405	137809628	3403803	130	43763											
FBXO18	84893	broad.mit.edu	37	chr10	5958267	5958267	+	Frame_Shift_Del	DEL	G	-	-																															tcaactccgtccttgctgaaGggaagggtggattcataaga																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:5958267delG	uc001iis.2	+	10	1731	c.1636delG	c.(1636-1638)GGGfs	p.G546fs	FBXO18_uc001iir.2_Frame_Shift_Del_p.G472fs|FBXO18_uc009xig.2_Frame_Shift_Del_p.G472fs|FBXO18_uc001iit.2_Frame_Shift_Del_p.G597fs	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	546					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						CCTTGCTGAAGGGAAGGGTGG	0.463													---	---	---								-	5958267	-	-	5958267	7	5	239	1	0	1	0	1	0	0	0	0	5763	1000	35	0	1836	0	FBXO18	10	5958267	Frame_Shift_Del	DEL	G	TCGA-CV-7250-01A-11D-2012-08		5958267	129576480	131	43764											
MLLT10	8028	broad.mit.edu	37	chr10	22021981	22021981	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aataacagcaaatcctagtcCgtctcatcaaatacacacat	17	9	3	12	1	2	0	2	0	1	0	5	0	4	0	2	0	3	1	2	0	6	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:22021981C>T	uc001iqs.2	+	19	2768	c.2420C>T	c.(2419-2421)CCG>CTG	p.P807L	MLLT10_uc001iqt.2_Missense_Mutation_p.P791L|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.P791L|MLLT10_uc001ira.2_Missense_Mutation_p.P248L|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	807					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						AATCCTAGTCCGTCTCATCAA	0.338			T	MLL|PICALM|CDK6	AL								7	67					0	0	0	0	T	22021981	T	T	22021981	3	4	239	1	0	0	0	0	1	0	0	0	9679	652	23	1	2490	1	MLLT10	10	22021981	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	16063714	22021981	113512766	132	43765											
KIAA1217	56243	broad.mit.edu	37	chr10	24825815	24825817	+	In_Frame_Del	DEL	AGA	-	-																															cgccacagtgccacccaaggAgaagaaggtaacgtggcaac																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:24825815_24825817delAGA	uc001iru.3	+	17	3930_3932	c.3527_3529delAGA	c.(3526-3531)GAGAAG>GAG	p.K1178del	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_In_Frame_Del_p.K1142del|KIAA1217_uc010qcz.1_In_Frame_Del_p.K1143del|KIAA1217_uc001irw.2_In_Frame_Del_p.K861del|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_In_Frame_Del_p.K861del|KIAA1217_uc001iry.2_In_Frame_Del_p.K861del	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1178					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CCACCCAAGGAGAAGAAGGTAAC	0.517													---	---	---								-	24825817	-	-	24825815	7	5	239	1	0	1	0	1	0	0	0	0	8255	304	11	0	3593	0	KIAA1217	10	24825815	In_Frame_Del	DEL	AGA	TCGA-CV-7250-01A-11D-2012-08	2803834	24825815	110708932	133	43766											
RASSF4	83937	broad.mit.edu	37	chr10	45484754	45484754	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actccagcctatggatccgtGaccaatgtgagggtcaacag	11	8	11	11	1	1	2	1	2	0	0	3	3	3	3	4	2	2	0	4	2	3	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:45484754G>A	uc001jbo.2	+	7	698	c.564G>A	c.(562-564)GTG>GTA	p.V188V	RASSF4_uc001jbp.2_Silent_p.V219V|RASSF4_uc009xmn.2_Silent_p.V118V|RASSF4_uc001jbq.2_Silent_p.V85V|RASSF4_uc001jbt.2_Silent_p.V145V	NM_032023	NP_114412	Q9H2L5	RASF4_HUMAN	Ras association domain family 4	188	Ras-associating.				cell cycle|signal transduction		protein binding			large_intestine(1)	1						ATGGATCCGTGACCAATGTGA	0.562													11	31					0	0	0	0	A	45484754	A	A	45484754	2	1	239	1	0	0	0	0	0	0	0	1	13153	1277	45	2		2	RASSF4	10	45484754	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	20658939	45484754	90049993	134	43767											
MYPN	84665	broad.mit.edu	37	chr10	69925475	69925475	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atagaggagatttgcaccttGgtcattgctgaggtgtttgc	8	14	13	6	0	1	3	1	1	0	2	1	4	1	3	1	3	3	3	1	3	1	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:69925475G>A	uc001jnm.3	+	10	1685	c.1500G>A	c.(1498-1500)TTG>TTA	p.L500L	MYPN_uc001jnl.1_Silent_p.L500L|MYPN_uc001jnn.3_Silent_p.L225L|MYPN_uc001jno.3_Silent_p.L500L|MYPN_uc009xps.2_Silent_p.L500L|MYPN_uc009xpt.2_Silent_p.L500L|MYPN_uc010qit.1_Silent_p.L206L|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	500	Interaction with CARP.|Ig-like 2.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TTTGCACCTTGGTCATTGCTG	0.413													5	44					0	0	0	0	A	69925475	A	A	69925475	2	1	239	1	0	0	0	0	0	0	0	1	10151	1339	47	4		4	MYPN	10	69925475	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	24440721	69925475	65609272	135	43768											
RUFY2	55680	broad.mit.edu	37	chr10	70139220	70139220	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggctgcagtaattttattgGttttttcttctagtcgggca	6	19	10	6	1	2	0	0	0	2	0	3	0	2	0	0	3	1	5	0	3	3	9			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:70139220G>C	uc001job.2	-	12	1598	c.1271C>G	c.(1270-1272)ACC>AGC	p.T424S	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joa.2_5'Flank|RUFY2_uc001joc.2_Missense_Mutation_p.T355S|RUFY2_uc010qiw.1_Missense_Mutation_p.T331S|RUFY2_uc001jod.1_Missense_Mutation_p.T389S	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	438	Potential.					nucleus	metal ion binding			ovary(1)	1						AATTTTATTGGTTTTTTCTTC	0.274													8	64					0	0	0	0	C	70139220	C	C	70139220	3	2	239	1	0	0	0	0	1	0	0	0	13804	1261	44	4	795	4	RUFY2	10	70139220	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	213745	70139220	65395527	136	43769											
TTC18	118491	broad.mit.edu	37	chr10	75059376	75059376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacttgccttctgagctcctCctgtccgacgggtaagagga	7	10	11	13	2	1	2	0	1	1	1	4	4	4	3	4	2	2	2	4	2	1	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:75059376C>T	uc009xrc.2	-	14	1635	c.1514G>A	c.(1513-1515)GGA>GAA	p.G505E	TTC18_uc001jty.2_Missense_Mutation_p.G505E|TTC18_uc009xrd.1_Missense_Mutation_p.G319E|TTC18_uc001jtx.2_5'Flank	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	505							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					CTGAGCTCCTCCTGTCCGACG	0.353													14	27					0	0	0	0	T	75059376	T	T	75059376	3	4	239	1	0	0	0	0	1	0	0	0	16753	855	30	2	1911	2	TTC18	10	75059376	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	4920156	75059376	60475371	137	43770											
BTRC	8945	broad.mit.edu	37	chr10	103291078	103291078	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcactttatcctaaaattatAcaagacattgaggtaagaat	17	12	6	6	0	0	3	0	1	0	2	1	3	1	3	1	1	1	2	1	1	8	7	rs146435684		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:103291078A>T	uc001kta.2	+	7	941	c.828A>T	c.(826-828)ATA>ATT	p.I276I	BTRC_uc001ktb.2_Silent_p.I240I|BTRC_uc001ktc.2_Silent_p.I250I	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	276					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CTAAAATTATACAAGACATTG	0.368													24	50					0	0	0	0	T	103291078	T	T	103291078	2	4	239	1	0	0	0	0	0	0	0	1	1574	381	14	5		5	BTRC	10	103291078	Silent	SNP	A	TCGA-CV-7250-01A-11D-2012-08	28231702	103291078	32243669	138	43771											
POLL	27343	broad.mit.edu	37	chr10	103343337	103343337	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagagctccaagacaggcacGctctcactgatatggtccag	12	7	10	12	1	1	3	1	1	1	2	4	3	3	3	2	2	1	3	2	2	3	1	rs148400497	byFrequency	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:103343337G>A	uc001ktg.1	-	5	1759	c.993C>T	c.(991-993)AGC>AGT	p.S331S	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_Silent_p.S23S|POLL_uc001kth.1_Silent_p.S56S|POLL_uc001kti.1_Silent_p.S331S|POLL_uc001ktj.1_Silent_p.S331S|POLL_uc001ktf.2_Silent_p.S239S|POLL_uc001ktk.1_Silent_p.S70S|POLL_uc010qqa.1_Silent_p.S70S|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Silent_p.S331S|POLL_uc001ktl.2_Silent_p.S243S|POLL_uc010qqc.1_Silent_p.S23S|POLL_uc010qqd.1_3'UTR	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	331					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		AGACAGGCACGCTCTCACTGA	0.562								DNA_polymerases_(catalytic_subunits)					15	29					0	0	0	0	A	103343337	A	A	103343337	2	1	239	1	0	0	0	0	0	0	0	1	12260	1078	38	1		1	POLL	10	103343337	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	52259	103343337	32191410	139	43772											
C10orf81	79949	broad.mit.edu	37	chr10	115534710	115534710	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggaattgattggtgtctttCccctgccgatgtggaagcac	8	12	12	9	1	1	1	0	1	1	0	2	4	2	3	3	3	2	1	3	3	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:115534710C>A	uc001lat.1	+	9	1449	c.887C>A	c.(886-888)TCC>TAC	p.S296Y	C10orf81_uc001lar.1_Missense_Mutation_p.S302Y|C10orf81_uc009xyc.1_Missense_Mutation_p.S214Y|C10orf81_uc001las.1_Missense_Mutation_p.S214Y|C10orf81_uc001lau.1_Missense_Mutation_p.S116Y	NM_024889	NP_079165	Q5SXH7	CJ081_HUMAN	hypothetical protein LOC79949	296										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		TGGTGTCTTTCCCCTGCCGAT	0.488													12	28					0.00010058	0.000381145	1	0	A	115534710	A	A	115534710	3	1	239	1	0	0	0	0	1	0	0	0	1625	855	30	2	939	2	C10orf81	10	115534710	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	12191373	115534710	20000037	140	43773											
GRK5	2869	broad.mit.edu	37	chr10	121182709	121182709	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catagcccaagttggccaagAcctggtctcccagacggagg	10	6	12	13	1	1	2	0	0	1	2	2	3	1	3	4	4	1	1	4	4	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:121182709A>C	uc001led.2	+	5	604	c.371A>C	c.(370-372)GAC>GCC	p.D124A	GRK5_uc009xzh.2_Missense_Mutation_p.D19A|GRK5_uc010qta.1_Missense_Mutation_p.D19A	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	124	N-terminal.|RGS.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GTTGGCCAAGACCTGGTCTCC	0.582													51	152					0	0	0	0	C	121182709	C	C	121182709	3	2	239	1	0	0	0	0	1	0	0	0	6831	275	10	5	389	5	GRK5	10	121182709	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	5647999	121182709	14352038	141	43774											
PPAPDC1A	196051	broad.mit.edu	37	chr10	122280508	122280508	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccgatttcttttaccgcTgctttccagatggagtgatg	6	14	10	11	2	1	2	0	1	1	1	2	4	2	3	4	1	2	2	4	1	1	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:122280508T>A	uc001lev.1	+	5	698	c.346T>A	c.(346-348)TGC>AGC	p.C116S	PPAPDC1A_uc010qtd.1_Missense_Mutation_p.C116S|PPAPDC1A_uc009xzl.1_Intron|PPAPDC1A_uc001lew.1_Intron|PPAPDC1A_uc001lex.1_Intron|PPAPDC1A_uc001ley.1_Intron	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	116					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		CTTTTACCGCTGCTTTCCAGA	0.512													21	57					0	0	0	0	A	122280508	A	A	122280508	3	1	239	1	0	0	0	0	1	0	0	0	12348	1580	55	5	364	5	PPAPDC1A	10	122280508	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	1097799	122280508	13254239	142	43775											
HRAS	3265	broad.mit.edu	37	chr11	533874	533874	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatggcgctgtactcctccTggccggcggtatccaggatg	5	9	14	13	3	0	0	0	0	0	0	3	1	3	1	4	5	1	4	4	5	2	2	rs121913233		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:533874T>A	uc001lpv.2	-	3	370	c.182A>T	c.(181-183)CAG>CTG	p.Q61L	HRAS_uc010qvw.1_Missense_Mutation_p.Q61L|HRAS_uc010qvx.1_Missense_Mutation_p.Q61L|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	61	GTP.		Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).	Q->V: Strongly increased transformation of cultured cell lines.|Q->I: Moderately increased transformation of cultured cell lines.	activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(112)|p.Q61L(93)|p.Q61K(39)|p.Q61H(20)|p.Q61P(3)|p.Q61Q(1)|p.Q61E(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597	Q61L(KNS62_LUNG)|Q61L(NCIH1915_LUNG)|Q61L(KYSE30_OESOPHAGUS)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			22	55					0	0	0	0	A	533874	A	A	533874	3	1	239	1	0	0	0	0	1	0	0	0	7387	1580	55	5	466	5	HRAS	11	533874	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08		533874	134472642	143	43776											
EPS8L2	64787	broad.mit.edu	37	chr11	720677	720677	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgcgctacccgtctgtgctGctgctcgtgtgccaggactc	3	11	12	15	3	1	0	0	0	1	0	3	1	1	1	2	1	6	4	2	1	1	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:720677G>A	uc001lqt.2	+	6	655	c.408G>A	c.(406-408)CTG>CTA	p.L136L	EPS8L2_uc010qwj.1_Silent_p.L152L|EPS8L2_uc001lqu.2_Silent_p.L136L|EPS8L2_uc010qwk.1_Silent_p.L152L|EPS8L2_uc001lqv.2_Silent_p.L91L|EPS8L2_uc001lqw.2_5'Flank|EPS8L2_uc001lqx.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	136	PID.					cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGTCTGTGCTGCTGCTCGTGT	0.582													5	7					0	0	0	0	A	720677	A	A	720677	2	1	239	1	0	0	0	0	0	0	0	1	5220	1306	46	4		4	EPS8L2	11	720677	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	186803	720677	134285839	144	43777											
NLRP14	338323	broad.mit.edu	37	chr11	7064303	7064303	+	Frame_Shift_Del	DEL	C	-	-																															ttttgaagataagaggtgggCcatgaaagtattcagttcac																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:7064303delC	uc001mfb.1	+	4	1369	c.1046delC	c.(1045-1047)GCCfs	p.A349fs		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	349	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AAGAGGTGGGCCATGAAAGTA	0.428													---	---	---								-	7064303	-	-	7064303	7	5	239	1	0	1	0	1	0	0	0	0	10530	739	26	0	1056	0	NLRP14	11	7064303	Frame_Shift_Del	DEL	C	TCGA-CV-7250-01A-11D-2012-08	6343626	7064303	127942213	145	43778											
EIF3M	10480	broad.mit.edu	37	chr11	32615476	32615476	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagaggacaatgcttcccagGctcgagttgatgcccacagg	10	7	12	12	1	0	2	0	1	0	1	2	4	1	3	2	3	2	3	2	3	1	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:32615476G>T	uc001mtu.2	+	6	641	c.598G>T	c.(598-600)GCT>TCT	p.A200S	EIF3M_uc010ref.1_Missense_Mutation_p.A68S	NM_006360	NP_006351	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3,	200						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)|breast(1)|skin(1)	3	Breast(20;0.109)					TGCTTCCCAGGCTCGAGTTGA	0.393													13	25					0.000219431	0.000828415	1	0	T	32615476	T	T	32615476	3	4	239	1	0	0	0	0	1	0	0	0	5047	1203	42	4	620	4	EIF3M	11	32615476	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	25551173	32615476	102391040	146	43779											
C11orf48	79081	broad.mit.edu	37	chr11	62439187	62439187	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcggctgcggggagctccCgtgggcgctccgctggctgt	1	9	18	13	5	0	0	0	0	0	0	2	1	2	1	2	5	3	5	2	5	0	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:62439187C>T	uc001nue.2	-						C11orf48_uc001nuf.2_5'UTR|C11orf48_uc010rmd.1_5'UTR|C11orf83_uc001nui.3_5'UTR	NM_024099	NP_077004	Q9BQE6	CK048_HUMAN	hypothetical protein LOC79081												0						GGGGAGCTCCCGTGGGCGCTC	0.657													9	40					0	0	0	0	T	62439187	T	T	62439187	1	4	239	0	1	0	0	0	0	0	0	0	1650	667	23	1		1	C11orf48	11	62439187	5'Flank	SNP	C	TCGA-CV-7250-01A-11D-2012-08	29823711	62439187	72567329	147	43780											
C11orf84	144097	broad.mit.edu	37	chr11	63585325	63585325	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagacccagcccgctagaggCaggcagtgatggctgtgagg	9	6	16	10	1	0	4	0	2	0	2	0	4	0	4	2	4	1	4	2	4	2	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:63585325C>A	uc001nxt.2	+	2	412	c.176C>A	c.(175-177)GCA>GAA	p.A59E		NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	59											0						CCGCTAGAGGCAGGCAGTGAT	0.637													4	12					2.56e-06	1.008e-05	1	0	A	63585325	A	A	63585325	3	1	239	1	0	0	0	0	1	0	0	0	1673	710	25	4	182	4	C11orf84	11	63585325	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	1146138	63585325	71421191	148	43781											
KRTAP5-10	387273	broad.mit.edu	37	chr11	71277066	71277066	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctcccagtgcaattgcTgtaagccctgctgctgctcc	5	11	10	15	0	0	0	0	0	0	0	2	0	2	0	3	0	7	8	3	0	2	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:71277066T>C	uc001oqt.1	+	1	458	c.433T>C	c.(433-435)TGT>CGT	p.C145R		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	145	3.|7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						GTGCAATTGCTGTAAGCCctg	0.348													47	102					0	0	0	0	C	71277066	C	C	71277066	3	2	239	1	0	0	0	0	1	0	0	0	8599	1580	55	5	435	5	KRTAP5-10	11	71277066	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	7691741	71277066	63729450	149	43782											
FAT3	120114	broad.mit.edu	37	chr11	92532912	92532912	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtcctgaaagttgttagcCctttggattatgaagttaca	10	14	11	6	0	0	2	0	2	0	0	1	3	1	3	2	2	2	3	2	2	5	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:92532912C>T	uc001pdj.3	+	9	6750	c.6733C>T	c.(6733-6735)CCT>TCT	p.P2245S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2245	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGTTGTTAGCCCTTTGGATTA	0.438										TCGA Ovarian(4;0.039)			7	16					0	0	0	0	T	92532912	T	T	92532912	3	4	239	1	0	0	0	0	1	0	0	0	5723	623	22	4	6767	4	FAT3	11	92532912	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	21255846	92532912	42473604	150	43783											
HEPHL1	341208	broad.mit.edu	37	chr11	93806191	93806191	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattcctatgtcttttcagTgactctgatctctacttcac	8	17	4	12	0	5	2	2	2	3	0	7	2	6	2	1	0	1	0	1	0	2	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:93806191T>G	uc001pep.2	+	7	1390	c.1233T>G	c.(1231-1233)AGT>AGG	p.S411R	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	411	Plastocyanin-like 3.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GTCTTTTCAGTGACTCTGATC	0.368													8	21					0	0	0	0	G	93806191	G	G	93806191	3	3	239	1	0	0	0	0	1	0	0	0	7094	1710	59	5	1259	5	HEPHL1	11	93806191	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	1273279	93806191	41200325	151	43784											
CADM1	23705	broad.mit.edu	37	chr11	115102137	115102137	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcttgctggccatagcagtGcagttgacttcaatctcctc	7	12	10	12	0	2	1	1	1	1	0	4	1	2	1	2	2	3	5	2	2	2	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:115102137G>A	uc001ppi.3	-	4	627	c.498C>T	c.(496-498)TGC>TGT	p.C166C	CADM1_uc001ppf.3_Silent_p.C166C|CADM1_uc001ppk.3_Silent_p.C166C|CADM1_uc001ppj.3_Silent_p.C166C|CADM1_uc001ppl.2_Silent_p.C166C	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	166	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		CCATAGCAGTGCAGTTGACTT	0.458													29	56					0	0	0	0	A	115102137	A	A	115102137	2	1	239	1	0	0	0	0	0	0	0	1	2578	1311	46	4		4	CADM1	11	115102137	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	21295946	115102137	19904379	152	43785											
BSX	390259	broad.mit.edu	37	chr11	122852272	122852272	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcgaaatggtctggggcCacctctctcagcggcttggg	5	9	15	12	2	3	0	1	0	2	0	4	1	3	0	2	6	1	1	2	6	1	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:122852272C>T	uc010rzs.1	-	1	108	c.108G>A	c.(106-108)GTG>GTA	p.V36V		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	36											0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		GGTCTGGGGCCACCTCTCTCA	0.612													3	4					0	0	0	0	T	122852272	T	T	122852272	2	4	239	1	0	0	0	0	0	0	0	1	1540	581	21	4		4	BSX	11	122852272	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	7750135	122852272	12154244	153	43786											
OR6T1	219874	broad.mit.edu	37	chr11	123814471	123814471	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attaaccccaggaacaccagGaactgtatgaggtggctact	13	8	10	10	0	0	1	0	1	0	0	0	3	0	3	3	4	4	2	3	4	5	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:123814471G>T	uc010sab.1	-	1	75	c.75C>A	c.(73-75)TTC>TTA	p.F25L		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GGAACACCAGGAACTGTATGA	0.488													36	74					5.43694e-19	2.42497e-18	1	0	T	123814471	T	T	123814471	3	4	239	1	0	0	0	0	1	0	0	0	11264	1165	41	2	899	2	OR6T1	11	123814471	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	962199	123814471	11192045	154	43787											
B4GALNT3	283358	broad.mit.edu	37	chr12	666883	666883	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcactgactatagcagtgaGgacatggatgttgagatggc	12	10	13	6	0	1	3	1	3	0	1	1	6	1	5	0	3	1	2	0	3	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:666883G>A	uc001qii.1	+	16	2490	c.2490G>A	c.(2488-2490)GAG>GAA	p.E830E	B4GALNT3_uc001qik.1_Silent_p.E379E	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	830	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			ATAGCAGTGAGGACATGGATG	0.522													14	21					0	0	0	0	A	666883	A	A	666883	2	1	239	1	0	0	0	0	0	0	0	1	1270	991	35	4		4	B4GALNT3	12	666883	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08		666883	133185012	155	43788											
SOX5	6660	broad.mit.edu	37	chr12	23999030	23999030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccagggctgtactagacaagGactcgccactctgtcgccca	9	7	10	15	2	1	1	0	0	1	1	3	2	1	2	3	2	1	2	3	2	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:23999030G>A	uc001rfw.2	-	3	470	c.368C>T	c.(367-369)TCC>TTC	p.S123F	SOX5_uc001rfx.2_Missense_Mutation_p.S110F|SOX5_uc001rfy.2_Missense_Mutation_p.S110F|SOX5_uc010siv.1_Missense_Mutation_p.S110F|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.S75F|SOX5_uc001rga.2_Missense_Mutation_p.S88F	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	123					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						ACTAGACAAGGACTCGCCACT	0.493													33	53					0	0	0	0	A	23999030	A	A	23999030	3	1	239	1	0	0	0	0	1	0	0	0	15018	1174	41	2	1985	2	SOX5	12	23999030	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	23332147	23999030	109852865	156	43789											
FAR2	55711	broad.mit.edu	37	chr12	29469874	29469874	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcttcacatcacagtactgGaatgcggtcagccaccgggc	10	7	11	13	2	3	0	3	0	0	0	3	1	3	1	2	3	4	2	2	3	2	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:29469874G>A	uc001ris.3	+	9	1203	c.1056G>A	c.(1054-1056)TGG>TGA	p.W352*	FAR2_uc001rit.2_Nonsense_Mutation_p.W352*|FAR2_uc009zjm.2_Nonsense_Mutation_p.W255*|uc001riu.1_Intron	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	352					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						CACAGTACTGGAATGCGGTCA	0.498													17	215					0	0	0	0	A	29469874	A	A	29469874	4	1	239	1	0	0	0	0	0	1	0	0	5707	1183	41	2	1086	2	FAR2	12	29469874	Nonsense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	5470844	29469874	104382021	157	43790											
LRRK2	120892	broad.mit.edu	37	chr12	40748281	40748281	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttgtttgtattgcaattccTtttccaagcaaaggtatggt	9	17	8	7	0	0	0	0	0	0	0	2	0	2	0	2	2	2	5	2	2	5	8			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:40748281T>A	uc001rmg.3	+	45	6878	c.6757T>A	c.(6757-6759)TTT>ATT	p.F2253I	LRRK2_uc009zjw.2_Missense_Mutation_p.F1091I|LRRK2_uc001rmi.2_Missense_Mutation_p.F1086I	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2253					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTGCAATTCCTTTTCCAAGCA	0.373													8	20					0	0	0	0	A	40748281	A	A	40748281	3	1	239	1	0	0	0	0	1	0	0	0	9083	1609	56	5	6935	5	LRRK2	12	40748281	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	11278407	40748281	93103614	158	43791											
OR8S1	341568	broad.mit.edu	37	chr12	48920192	48920192	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcaggtttgctccgccatCtcatgccaaactcaggttcc	7	11	8	15	1	3	0	3	0	1	0	6	0	5	0	4	2	3	4	4	2	1	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:48920192C>G	uc010slu.1	+	1	778	c.778C>G	c.(778-780)CTC>GTC	p.L260V		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCTCCGCCATCTCATGCCAAA	0.498													22	49					0	0	0	0	G	48920192	G	G	48920192	3	3	239	1	0	0	0	0	1	0	0	0	11300	913	32	2	780	2	OR8S1	12	48920192	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	8171911	48920192	84931703	159	43792											
HOXC9	3225	broad.mit.edu	37	chr12	54396248	54396248	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactggattcacgcccgctcCacgaggaagaagcgctgccc	10	5	11	15	4	1	1	1	0	0	1	2	4	2	3	3	2	3	2	3	2	3	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:54396248C>A	uc001sep.2	+	3	671	c.573C>A	c.(571-573)TCC>TCA	p.S191S	HOXC9_uc001seq.2_Silent_p.S191S	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	191					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						ACGCCCGCTCCACGAGGAAGA	0.567													6	109					5.18039e-06	2.03184e-05	1	0	A	54396248	A	A	54396248	2	1	239	1	0	0	0	0	0	0	0	1	7356	581	21	4		4	HOXC9	12	54396248	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	5476056	54396248	79455647	160	43793											
CDK4	1019	broad.mit.edu	37	chr12	58142978	58142978	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagtaccagcagcagctgtGctcccgactcctccatctca	8	8	7	18	1	1	0	1	0	1	0	5	1	4	0	5	0	5	5	5	0	1	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:58142978G>A	uc001spv.2	-	7	1033	c.806C>T	c.(805-807)GCA>GTA	p.A269V	CDK4_uc010ssb.1_Missense_Mutation_p.A149V|CDK4_uc001spw.2_RNA|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	269	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CAGCAGCTGTGCTCCCGACTC	0.602			Mis			melanoma 			Hereditary_Melanoma				18	74					0	0	0	0	A	58142978	A	A	58142978	3	1	239	1	0	0	0	0	1	0	0	0	3156	1319	46	4	113	4	CDK4	12	58142978	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	3746730	58142978	75708917	161	43794											
GLIPR1	11010	broad.mit.edu	37	chr12	75889388	75889388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caacttggccatataagagaGgagccacctgcagtgcctgc	11	7	11	12	0	0	1	0	0	0	1	0	3	0	2	4	2	5	1	4	2	3	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:75889388G>A	uc001sxs.2	+	4	713	c.565G>A	c.(565-567)GGA>AGA	p.G189R	GLIPR1_uc009zsb.1_Silent_p.E212E	NM_006851	NP_006842	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1 precursor	189					cellular lipid metabolic process	extracellular region|integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3						ATATAAGAGAGGAGCCACCTG	0.378													3	24					0	0	0	0	A	75889388	A	A	75889388	3	1	239	1	0	0	0	0	1	0	0	0	6478	1001	35	4	579	4	GLIPR1	12	75889388	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	17746410	75889388	57962507	162	43795											
C12orf12	196477	broad.mit.edu	37	chr12	91348312	91348312	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaaaagcccgggccgtgctGttgcttcggctgcttccttg	4	11	12	14	3	0	0	0	0	0	0	2	0	1	0	4	2	4	5	4	2	2	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:91348312G>T	uc001tbj.2	-	1	642	c.208C>A	c.(208-210)CAG>AAG	p.Q70K		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	70										central_nervous_system(1)|pancreas(1)	2						GGGCCGTGCTGTTGCTTCGGC	0.642													12	16					1.08611e-07	4.34443e-07	1	0	T	91348312	T	T	91348312	3	4	239	1	0	0	0	0	1	0	0	0	1682	1386	48	4	1016	4	C12orf12	12	91348312	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	15458924	91348312	42503583	163	43796											
TMEM132B	114795	broad.mit.edu	37	chr12	126138423	126138424	+	Missense_Mutation	DNP	GA	TG	TG																															agcaccaaggaggcagcaatGatattgagggcataaatcgg																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:126138423_126138424GA>TG	uc001uhe.1	+	9	2412_2413	c.2404_2405GA>TG	c.(2404-2406)GAT>TGT	p.D802C	TMEM132B_uc001uhf.1_Missense_Mutation_p.D314C	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	802	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGGCAGCAATGATATTGAGGGC	0.475													6	57					0	0	0	0	TG	126138424	TG	TG	126138423	3	4	239	1	0	0	0	0	1	0	0	0	16112	1290	45	2	2438	2	TMEM132B	12	126138423	Missense_Mutation	DNP	GA	TCGA-CV-7250-01A-11D-2012-08	34790111	126138423	7713472	164	43797											
ZMYM2	7750	broad.mit.edu	37	chr13	20641147	20641148	+	Frame_Shift_Del	DEL	GA	-	-																															aagatcttctggtattagatGagttaaaatcttgtaagtgt																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:20641147_20641148delGA	uc001umr.2	+	21	3587_3588	c.3289_3290delGA	c.(3289-3291)GAGfs	p.E1097fs	ZMYM2_uc001ums.2_Frame_Shift_Del_p.E1097fs|ZMYM2_uc001umt.2_Frame_Shift_Del_p.E1097fs|ZMYM2_uc001umv.2_Frame_Shift_Del_p.E477fs|ZMYM2_uc001umw.2_Frame_Shift_Del_p.E550fs	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	1097					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		GGTATTAGATGAGTTAAAATCT	0.302													---	---	---								-	20641148	-	-	20641147	7	5	239	1	0	1	0	1	0	0	0	0	17767	1291	45	0	3359	0	ZMYM2	13	20641147	Frame_Shift_Del	DEL	GA	TCGA-CV-7250-01A-11D-2012-08		20641147	94528731	165	43798											
N6AMT2	221143	broad.mit.edu	37	chr13	21331600	21331600	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcatttacttacccaattCtcttctattattccaatgtt	10	19	2	10	0	2	0	0	0	2	0	4	0	3	0	2	0	3	2	2	0	6	9			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:21331600C>T	uc001uno.1	-	2	219	c.138G>A	c.(136-138)GAG>GAA	p.E46E	N6AMT2_uc009zzr.1_Silent_p.E46E|N6AMT2_uc001unp.2_RNA	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	46							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		TTACCCAATTCTCTTCTATTA	0.418													23	57					0	0	0	0	T	21331600	T	T	21331600	2	4	239	1	0	0	0	0	0	0	0	1	10168	912	32	2		2	N6AMT2	13	21331600	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	690453	21331600	93838278	166	43799											
STARD13	90627	broad.mit.edu	37	chr13	33703125	33703125	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgtctctgaccccaggAggctcagattcattaagaga	10	10	9	12	0	3	3	2	1	1	2	5	5	4	4	3	2	0	1	3	2	1	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:33703125A>G	uc001uuw.2	-	5	1815	c.1689T>C	c.(1687-1689)CCT>CCC	p.P563P	STARD13_uc001uuu.2_Silent_p.P555P|STARD13_uc001uuv.2_Silent_p.P445P|STARD13_uc001uux.2_Silent_p.P528P|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Silent_p.P548P	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	563					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		TGACCCCAGGAGGCTCAGATT	0.473													18	32					0	0	0	0	G	33703125	G	G	33703125	2	3	239	1	0	0	0	0	0	0	0	1	15322	291	11	5		5	STARD13	13	33703125	Silent	SNP	A	TCGA-CV-7250-01A-11D-2012-08	12371525	33703125	81466753	167	43800											
TRPC4	7223	broad.mit.edu	37	chr13	38320520	38320520	+	Frame_Shift_Del	DEL	G	-	-																															tatctcataattatttgtatGggctgccaaaatgattggtg																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:38320520delG	uc001uws.2	-	3	686	c.451delC	c.(451-453)CATfs	p.H151fs	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Frame_Shift_Del_p.H151fs|TRPC4_uc010tey.1_Frame_Shift_Del_p.H151fs|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Frame_Shift_Del_p.H151fs|TRPC4_uc010aby.2_Frame_Shift_Del_p.H151fs	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	151	Cytoplasmic (Potential).|ANK 4.|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTATTTGTATGGGCTGCCAAA	0.433													---	---	---								-	38320520	-	-	38320520	7	5	239	1	0	1	0	1	0	0	0	0	16647	1348	47	0	2533	0	TRPC4	13	38320520	Frame_Shift_Del	DEL	G	TCGA-CV-7250-01A-11D-2012-08	4617395	38320520	76849358	168	43801											
LRCH1	23143	broad.mit.edu	37	chr13	47315858	47315859	+	Missense_Mutation	DNP	GG	TT	TT																															ttgacactctgctggcactcGgggagaaagccccaccacca																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:47315858_47315859GG>TT	uc001vbj.2	+	19	2298_2299	c.2062_2063GG>TT	c.(2062-2064)GGG>TTG	p.G688L	LRCH1_uc001vbk.2_Missense_Mutation_p.G723L|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	688	CH.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GCTGGCACTCGGGGAGAAAGCC	0.515													8	419					0	0	0	0	TT	47315859	TT	TT	47315858	3	4	239	1	0	0	0	0	1	0	0	0	8982	1116	39	3	2245	3	LRCH1	13	47315858	Missense_Mutation	DNP	GG	TCGA-CV-7250-01A-11D-2012-08	8995338	47315858	67854020	169	43802											
SLITRK6	84189	broad.mit.edu	37	chr13	86368987	86368987	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctttcaattcctttttgtCgagatgcccgggggaagtgc	6	13	13	9	2	1	1	1	0	0	1	3	3	2	2	2	3	2	1	2	3	2	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:86368987C>T	uc001vll.1	-	2	2116	c.1657G>A	c.(1657-1659)GAC>AAC	p.D553N	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	553	LRRCT 2.|Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCCTTTTTGTCGAGATGCCCG	0.458													11	54					0	0	0	0	T	86368987	T	T	86368987	3	4	239	1	0	0	0	0	1	0	0	0	14811	884	31	1	872	1	SLITRK6	13	86368987	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	39053129	86368987	28800891	170	43803											
OXGR1	27199	broad.mit.edu	37	chr13	97639754	97639754	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	catagtagtgaatcaggaagGggaggctggtcagatacagc	13	7	15	6	0	2	2	2	1	0	1	2	4	2	4	0	5	2	2	0	5	5	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:97639754G>T	uc001vmx.1	-	4	504	c.260C>A	c.(259-261)CCC>CAC	p.P87H	OXGR1_uc010afr.1_Missense_Mutation_p.P87H	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	87	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			AATCAGGAAGGGGAGGCTGGT	0.453													10	16					2.17888e-05	8.41497e-05	1	0	T	97639754	T	T	97639754	3	4	239	1	0	0	0	0	1	0	0	0	11386	1232	43	4	757	4	OXGR1	13	97639754	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	11270767	97639754	17530124	171	43804											
OR4K5	79317	broad.mit.edu	37	chr14	20389043	20389043	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgcacacgagaccatatCtttcagtggctgcatagccc	10	9	10	12	1	2	1	1	0	1	1	2	3	2	1	2	1	3	3	2	1	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:20389043C>A	uc010tkw.1	+	1	278	c.278C>A	c.(277-279)TCT>TAT	p.S93Y		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GAGACCATATCTTTCAGTGGC	0.418													57	295					8.99859e-20	4.03137e-19	1	0	A	20389043	A	A	20389043	3	1	239	1	0	0	0	0	1	0	0	0	11127	913	32	2	280	2	OR4K5	14	20389043	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08		20389043	86960497	172	43805											
NOVA1	4857	broad.mit.edu	37	chr14	26918046	26918046	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaaccctctcttgcaagtTgatcccatcaggtttctggg	8	12	9	12	0	3	1	1	1	2	0	5	2	4	1	2	2	2	3	2	2	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:26918046T>A	uc001wpy.2	-	5	961	c.643A>T	c.(643-645)AAC>TAC	p.N215Y	NOVA1_uc001wpz.2_Missense_Mutation_p.N191Y|NOVA1_uc001wqa.2_Missense_Mutation_p.N93Y	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	218	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		TCTTGCAAGTTGATCCCATCA	0.488													43	76					0	0	0	0	A	26918046	A	A	26918046	3	1	239	1	0	0	0	0	1	0	0	0	10608	1812	63	5	884	5	NOVA1	14	26918046	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	6529003	26918046	80431494	173	43806											
BAZ1A	11177	broad.mit.edu	37	chr14	35245154	35245154	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaatttctcttcagaaaaaCgggctagctgtgcacatatt	13	12	8	8	1	2	1	1	0	1	1	3	2	2	1	0	1	3	3	0	1	5	5	rs116485187	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:35245154C>T	uc001wsk.2	-	18	3372	c.2804G>A	c.(2803-2805)CGT>CAT	p.R935H	BAZ1A_uc001wsl.2_Missense_Mutation_p.R903H	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	935					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TTCAGAAAAACGGGCTAGCTG	0.353													10	29					0	0	0	0	T	35245154	T	T	35245154	3	4	239	1	0	0	0	0	1	0	0	0	1331	536	19	1	1906	1	BAZ1A	14	35245154	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	8327108	35245154	72104386	174	43807											
SLC8A3	6547	broad.mit.edu	37	chr14	70633784	70633784	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcctggcttcagaaccacCgtgccctctgtgaactcata	8	11	7	15	1	4	2	2	1	2	1	5	2	4	2	4	1	3	1	4	1	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:70633784C>A	uc001xly.2	-	2	2110	c.1356G>T	c.(1354-1356)ACG>ACT	p.T452T	SLC8A3_uc001xlw.2_Silent_p.T452T|SLC8A3_uc001xlx.2_Silent_p.T452T|SLC8A3_uc001xlz.2_Silent_p.T452T|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	452	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCAGAACCACCGTGCCCTCTG	0.488													45	106					1.7489e-18	7.76606e-18	1	0	A	70633784	A	A	70633784	2	1	239	1	0	0	0	0	0	0	0	1	14772	639	23	3		3	SLC8A3	14	70633784	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	35388630	70633784	36715756	175	43808											
SLC8A3	6547	broad.mit.edu	37	chr14	70634902	70634902	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtatatcagggccacaaaatAgacaatgaccctggcaatct	15	8	8	10	0	2	2	1	1	1	1	2	2	2	2	2	2	0	2	2	2	7	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:70634902A>G	uc001xly.2	-	2	992	c.238T>C	c.(238-240)TAT>CAT	p.Y80H	SLC8A3_uc001xlw.2_Missense_Mutation_p.Y80H|SLC8A3_uc001xlx.2_Missense_Mutation_p.Y80H|SLC8A3_uc001xlz.2_Missense_Mutation_p.Y80H|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	80	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GCCACAAAATAGACAATGACC	0.522													12	24					0	0	0	0	G	70634902	G	G	70634902	3	3	239	1	0	0	0	0	1	0	0	0	14772	420	15	5	2684	5	SLC8A3	14	70634902	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	1118	70634902	36714638	176	43809											
PTPN21	11099	broad.mit.edu	37	chr14	88940131	88940131	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aattttttttgcatctactcGagtctttttcattccctgta	7	21	4	9	1	3	0	1	0	2	0	5	1	4	0	1	0	2	2	1	0	3	9			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:88940131G>A	uc001xwv.3	-	14	2858	c.2527C>T	c.(2527-2529)CGA>TGA	p.R843*	PTPN21_uc010twc.1_Nonsense_Mutation_p.R639*	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	843						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GCATCTACTCGAGTCTTTTTC	0.398													5	41					0	0	0	0	A	88940131	A	A	88940131	4	1	239	1	0	0	0	0	0	1	0	0	12851	1066	37	1	1021	1	PTPN21	14	88940131	Nonsense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	18305229	88940131	18409409	177	43810											
TECPR2	9895	broad.mit.edu	37	chr14	102900897	102900897	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgcacatgggcgggagctGctcaatggagcgagggaaga	11	5	17	8	2	1	1	1	0	0	1	1	5	1	4	0	4	4	3	0	4	2	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:102900897G>T	uc001ylw.1	+	9	1891	c.1743G>T	c.(1741-1743)CTG>CTT	p.L581L	TECPR2_uc010awl.2_Silent_p.L581L|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	581							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						GGCGGGAGCTGCTCAATGGAG	0.532													11	30					1.58986e-06	6.28464e-06	1	0	T	102900897	T	T	102900897	2	4	239	1	0	0	0	0	0	0	0	1	15810	1306	46	4		4	TECPR2	14	102900897	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	13960766	102900897	4448643	178	43811											
SNURF	8926	broad.mit.edu	37	chr15	25213157	25213157	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgaactgaggcaggcattCttagctgagacaccaagagg	12	7	13	9	0	1	4	0	3	1	2	1	5	1	4	1	3	2	4	1	3	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:25213157C>T	uc001ywu.2	+	3	315	c.189C>T	c.(187-189)TTC>TTT	p.F63F	SNRPN_uc001ywp.1_5'UTR|SNRPN_uc001ywq.1_5'UTR|SNRPN_uc001ywr.1_5'UTR|SNRPN_uc001yws.1_Intron|SNRPN_uc001ywt.1_5'UTR|SNRPN_uc001ywv.1_5'UTR|SNRPN_uc001yww.1_5'UTR|SNRPN_uc001ywx.1_5'UTR|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_RNA|SNRPN_uc001ywy.1_Silent_p.F63F	NM_022804	NP_073715	Q9Y675	SNURF_HUMAN	SNRPN upstream reading frame protein	63						nucleus					0		all_cancers(20;1.4e-21)|Breast(32;0.000625)		all cancers(64;3.48e-07)|Epithelial(43;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0142)		GGCAGGCATTCTTAGCTGAGA	0.468													4	60					0	0	0	0	T	25213157	T	T	25213157	2	4	239	1	0	0	0	0	0	0	0	1	14942	912	32	2		2	SNURF	15	25213157	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08		25213157	77318235	179	43812											
ATP10A	57194	broad.mit.edu	37	chr15	25959362	25959362	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcttctatcgtcttcaccggGgacttcagctcaaacctcac	8	12	6	15	2	7	0	4	0	3	0	8	1	7	1	2	2	2	1	2	2	2	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:25959362G>T	uc010ayu.2	-	10	1909	c.1803C>A	c.(1801-1803)TCC>TCA	p.S601S		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	601	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TCTTCACCGGGGACTTCAGCT	0.607													16	31					6.31663e-08	2.54686e-07	1	0	T	25959362	T	T	25959362	2	4	239	1	0	0	0	0	0	0	0	1	1118	1219	43	4		4	ATP10A	15	25959362	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	746205	25959362	76572030	180	43813											
TJP1	7082	broad.mit.edu	37	chr15	30003119	30003119	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcatactgcgagggcaatgGaggaggagggggagtggcct	9	5	21	6	1	0	0	0	0	0	0	0	5	0	4	1	8	2	2	1	8	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:30003119G>C	uc001zcr.2	-	24	4763	c.4288C>G	c.(4288-4290)CCA>GCA	p.P1430A	TJP1_uc010azl.2_Missense_Mutation_p.P1418A|TJP1_uc001zcq.2_Missense_Mutation_p.P1354A|TJP1_uc001zcs.2_Missense_Mutation_p.P1350A	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1430	Poly-Pro.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GAGGGCAATGGAGGAGGAGGG	0.532													76	109					0	0	0	0	C	30003119	C	C	30003119	3	2	239	1	0	0	0	0	1	0	0	0	15995	1174	41	2	978	2	TJP1	15	30003119	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	4043757	30003119	72528273	181	43814											
TJP1	7082	broad.mit.edu	37	chr15	30033539	30033539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttaaaattgtattaccgaaGaatcccatcttcatgagttg	13	15	6	7	1	2	2	1	1	1	1	3	3	3	2	2	0	1	2	2	0	6	7			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:30033539G>A	uc001zcr.2	-	10	1727	c.1252C>T	c.(1252-1254)CTT>TTT	p.L418F	TJP1_uc010azl.2_Missense_Mutation_p.L406F|TJP1_uc001zcq.2_Missense_Mutation_p.L422F|TJP1_uc001zcs.2_Missense_Mutation_p.L418F	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	418					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TATTACCGAAGAATCCCATCT	0.338													19	23					0	0	0	0	A	30033539	A	A	30033539	3	1	239	1	0	0	0	0	1	0	0	0	15995	942	33	2	4070	2	TJP1	15	30033539	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	30420	30033539	72497853	182	43815											
SLC12A6	9990	broad.mit.edu	37	chr15	34529660	34529661	+	Frame_Shift_Ins	INS	-	A	A																															cgcctcaatgcgtaagtgatINSataggaaggtggctaggtcc																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:34529660_34529661insA	uc001zhw.2	-	21	3057_3058	c.2893_2894insT	c.(2893-2895)TATfs	p.Y965fs	SLC12A6_uc001zhv.2_Frame_Shift_Ins_p.Y914fs|SLC12A6_uc001zhx.2_Frame_Shift_Ins_p.Y950fs|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Frame_Shift_Ins_p.Y906fs|SLC12A6_uc001zib.2_Frame_Shift_Ins_p.Y956fs|SLC12A6_uc001zic.2_Frame_Shift_Ins_p.Y965fs|SLC12A6_uc010bau.2_Frame_Shift_Ins_p.Y965fs|SLC12A6_uc001zid.2_Frame_Shift_Ins_p.Y906fs|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Frame_Shift_Ins_p.Y777fs	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	965	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	GCGTAAGTGATATAGGAAGGTG	0.48													---	---	---								A	34529661	A	A	34529660	7	5	239	1	0	1	1	0	0	0	0	0	14452	1406	49	0	578	0	SLC12A6	15	34529660	Frame_Shift_Ins	INS	-	TCGA-CV-7250-01A-11D-2012-08	4496121	34529660	68001732	183	43816											
MAPKBP1	23005	broad.mit.edu	37	chr15	42107957	42107957	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggtgtgtgtcagccccaatGgacagcatctagcatcaggg	9	8	13	11	1	3	0	2	0	1	0	3	1	3	1	2	3	3	2	2	3	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:42107957G>C	uc001zok.3	+	13	1757	c.1471G>C	c.(1471-1473)GGA>CGA	p.G491R	MAPKBP1_uc001zoj.3_Missense_Mutation_p.G485R|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.G485R|MAPKBP1_uc010udb.1_Missense_Mutation_p.G324R|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	491	WD 7.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CAGCCCCAATGGACAGCATCT	0.592													10	26					0	0	0	0	C	42107957	C	C	42107957	3	2	239	1	0	0	0	0	1	0	0	0	9345	1349	47	4	1517	4	MAPKBP1	15	42107957	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	7578297	42107957	60423435	184	43817											
USP8	9101	broad.mit.edu	37	chr15	50788056	50788056	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tatttccaggctgataatcgGaagagatataaagaagaaaa	19	9	9	4	1	0	4	0	1	0	3	2	6	1	5	1	2	0	1	1	2	9	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:50788056G>C	uc001zym.3	+	18	3170	c.2670G>C	c.(2668-2670)CGG>CGC	p.R890R	USP8_uc001zyl.3_Silent_p.R890R|USP8_uc001zyn.3_Silent_p.R890R|USP8_uc010ufh.1_Silent_p.R784R|uc001zyo.1_5'Flank|USP8_uc001zyp.3_Silent_p.R57R	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	890					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CTGATAATCGGAAGAGATATA	0.318													6	16					0	0	0	0	C	50788056	C	C	50788056	2	2	239	1	0	0	0	0	0	0	0	1	17157	1161	41	2		2	USP8	15	50788056	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	8680099	50788056	51743336	185	43818											
ALPK3	57538	broad.mit.edu	37	chr15	85399896	85399896	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ataggaagacgcaggtggatGctgggacacaagaaagcaag	16	4	15	6	1	0	2	0	0	0	2	0	5	0	5	0	4	2	3	0	4	5	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:85399896G>T	uc002ble.2	+	6	2700	c.2533G>T	c.(2533-2535)GCT>TCT	p.A845S		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	845					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCAGGTGGATGCTGGGACACA	0.547													9	26					5.4927e-09	2.25067e-08	1	0	T	85399896	T	T	85399896	3	4	239	1	0	0	0	0	1	0	0	0	546	1319	46	4	2555	4	ALPK3	15	85399896	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	34611840	85399896	17131496	186	43819											
MAN2A2	4122	broad.mit.edu	37	chr15	91455444	91455444	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcattgactctggcaccAgcgacttcgccctcagcaac	8	9	9	15	2	3	1	2	1	1	0	4	2	3	1	2	1	3	2	2	1	1	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:91455444A>C	uc010bnz.2	+	15	2396	c.2281A>C	c.(2281-2283)AGC>CGC	p.S761R	MAN2A2_uc002bqc.2_Missense_Mutation_p.S761R|MAN2A2_uc010uql.1_Missense_Mutation_p.S423R|MAN2A2_uc010uqm.1_Missense_Mutation_p.S340R|MAN2A2_uc010uqn.1_RNA	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	761	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CTCTGGCACCAGCGACTTCGC	0.637													30	66					0	0	0	0	C	91455444	C	C	91455444	3	2	239	1	0	0	0	0	1	0	0	0	9268	188	7	5	2335	5	MAN2A2	15	91455444	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	6055548	91455444	11075948	187	43820											
PHKB	5257	broad.mit.edu	37	chr16	47627442	47627442	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattgaatgtgaatttcccaTatttttcctttatatgatga	11	19	5	6	0	0	4	0	4	0	0	2	4	2	4	2	0	0	0	2	0	5	8			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr16:47627442T>C	uc002eev.3	+	11	1152	c.1100T>C	c.(1099-1101)ATA>ACA	p.I367T	PHKB_uc002eeu.3_Missense_Mutation_p.I360T	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	367					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				GAATTTCCCATATTTTTCCTT	0.229													10	18					0	0	0	0	C	47627442	C	C	47627442	3	2	239	1	0	0	0	0	1	0	0	0	11900	1406	49	5	1201	5	PHKB	16	47627442	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08		47627442	42727311	188	43821											
CES2	8824	broad.mit.edu	37	chr16	66976677	66976677	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgttttcagaagtttctttgGgggcaactacagtgagtctt	8	16	11	6	0	3	2	1	1	2	1	3	2	3	2	0	2	2	3	0	2	3	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr16:66976677G>A	uc002eqr.2	+	10	2601	c.1601G>A	c.(1600-1602)GGG>GAG	p.G534E	CES2_uc002eqq.2_Intron|CES2_uc002eqs.2_Missense_Mutation_p.G377E	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	470					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		AGTTTCTTTGGGGGCAACTAC	0.473													8	47					0	0	0	0	A	66976677	A	A	66976677	3	1	239	1	0	0	0	0	1	0	0	0	3285	1232	43	4	1639	4	CES2	16	66976677	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	19349235	66976677	23378076	189	43822											
MYH8	4626	broad.mit.edu	37	chr17	10318656	10318656	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agttttggcattgccaaaggCctccagtaggggattggcgc	8	10	14	9	1	0	0	0	0	0	0	1	1	1	1	3	5	1	3	3	5	2	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:10318656C>G	uc002gmm.2	-	8	789	c.694G>C	c.(694-696)GCC>CCC	p.A232P	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	232	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTGCCAAAGGCCTCCAGTAGG	0.502									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				28	75					0	0	0	0	G	10318656	G	G	10318656	3	3	239	1	0	0	0	0	1	0	0	0	10094	739	26	4	5251	4	MYH8	17	10318656	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08		10318656	70876554	190	43823											
DNAH9	1770	broad.mit.edu	37	chr17	11573072	11573072	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattattaagaggtggagccTcctgttcaaacagcatcttg	11	13	9	8	0	2	1	1	0	1	1	3	2	3	2	2	2	3	2	2	2	4	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:11573072T>G	uc002gne.2	+	17	3382	c.3314T>G	c.(3313-3315)CTC>CGC	p.L1105R	DNAH9_uc010coo.2_Missense_Mutation_p.L399R	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1105	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGGTGGAGCCTCCTGTTCAAA	0.453													40	95					0	0	0	0	G	11573072	G	G	11573072	3	3	239	1	0	0	0	0	1	0	0	0	4630	1551	54	5	3380	5	DNAH9	17	11573072	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	1254416	11573072	69622138	191	43824											
KCNJ12	3768	broad.mit.edu	37	chr17	21319765	21319765	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacaagttcctgctgcccAgcgccaactccttctgctac	9	9	7	16	1	1	1	0	0	1	1	3	1	3	1	4	0	7	3	4	0	4	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:21319765A>T	uc002gyv.1	+	3	1816	c.1111A>T	c.(1111-1113)AGC>TGC	p.S371C		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	371	Cytoplasmic (By similarity).			S -> R (in Ref. 2; AAC50615).	blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCTGCTGCCCAGCGCCAACTC	0.607										Prostate(3;0.18)			5	84					0	0	0	0	T	21319765	T	T	21319765	3	4	239	1	0	0	0	0	1	0	0	0	8085	188	7	5	1113	5	KCNJ12	17	21319765	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	9746693	21319765	59875445	192	43825											
ERBB2	2064	broad.mit.edu	37	chr17	37881982	37881982	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgactgtgtgggagctgatGacttttggggccaaacctta	8	12	14	7	0	0	3	0	3	0	0	0	4	0	4	2	3	2	1	2	3	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:37881982G>A	uc002hso.2	+	23	2986	c.2748G>A	c.(2746-2748)ATG>ATA	p.M916I	ERBB2_uc002hsm.2_Missense_Mutation_p.M886I|ERBB2_uc010cwa.2_Missense_Mutation_p.M901I|ERBB2_uc002hsp.2_Missense_Mutation_p.M719I|ERBB2_uc010cwb.2_Missense_Mutation_p.M916I|ERBB2_uc010wek.1_Missense_Mutation_p.M640I	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	916	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GGGAGCTGATGACTTTTGGGG	0.602		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			6	64					0	0	0	0	A	37881982	A	A	37881982	3	1	239	1	0	0	0	0	1	0	0	0	5230	1290	45	2	2838	2	ERBB2	17	37881982	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	16562217	37881982	43313228	193	43826											
KRT9	3857	broad.mit.edu	37	chr17	39726431	39726440	+	Frame_Shift_Del	DEL	GTCCAGGAGA	-	-																															gtcatgcgagtgttgtcaatGtccaggagagttttgttgtt																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:39726431_39726440delGTCCAGGAGA	uc002hxe.3	-	2	741_750	c.675_684delTCTCCTGGAC	c.(673-684)ACTCTCCTGGACfs	p.T225fs	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	225_228	Rod.|Coil 1B.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				TGTTGTCAATGTCCAGGAGAGTTTTGTTGT	0.51													---	---	---								-	39726440	-	-	39726431	7	5	239	1	0	1	0	1	0	0	0	0	8540	1368	48	0	1211	0	KRT9	17	39726431	Frame_Shift_Del	DEL	GTCCAGGAGA	TCGA-CV-7250-01A-11D-2012-08	1844449	39726431	41468779	194	43827											
BRCA1	672	broad.mit.edu	37	chr17	41222997	41222997	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacattcttttgttgaccCtttctgttgaagctgtcaat	7	18	8	8	0	3	2	1	2	2	0	3	3	3	3	1	1	1	3	1	1	2	6	rs80357653		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:41222997C>A	uc002icq.2	-	15	5166	c.4934G>T	c.(4933-4935)AGG>ATG	p.R1645M	BRCA1_uc010whp.1_Missense_Mutation_p.R494M|BRCA1_uc010whl.1_Missense_Mutation_p.R541M|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.R1574M|BRCA1_uc002icu.2_Missense_Mutation_p.R541M|BRCA1_uc010cyx.2_Missense_Mutation_p.R1598M|BRCA1_uc002ict.2_Missense_Mutation_p.R1666M|BRCA1_uc010whn.1_Missense_Mutation_p.R136M|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Missense_Mutation_p.R374M|BRCA1_uc002idc.1_Missense_Mutation_p.R541M|BRCA1_uc010whr.1_Missense_Mutation_p.R495M	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1645	BRCT 1.				androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TTTGTTGACCCTTTCTGTTGA	0.443			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			59	64					3.00063e-23	1.35634e-22	1	0	A	41222997	A	A	41222997	3	1	239	1	0	0	0	0	1	0	0	0	1503	681	24	4	693	4	BRCA1	17	41222997	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	1496566	41222997	39972213	195	43828											
ASB16	92591	broad.mit.edu	37	chr17	42248236	42248236	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aggagtggctggaatgggagGaccggcggcgggcggctgcc	6	4	22	9	4	0	0	0	0	0	0	0	4	0	4	2	9	1	2	2	9	1	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:42248236G>C	uc002ifl.1	+	1	163	c.79G>C	c.(79-81)GAC>CAC	p.D27H	ASB16_uc002ifm.1_RNA	NM_080863	NP_543139	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box-containing protein	27					intracellular signal transduction		protein binding			kidney(2)	2		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGAATGGGAGGACCGGCGGCG	0.697													10	45					0	0	0	0	C	42248236	C	C	42248236	3	2	239	1	0	0	0	0	1	0	0	0	1022	1174	41	2	81	2	ASB16	17	42248236	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	1025239	42248236	38946974	196	43829											
SKAP1	8631	broad.mit.edu	37	chr17	46239901	46239901	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggtcaccatggcaatccCataggccctggtagtaactg	9	9	11	12	0	1	0	1	0	0	0	2	0	2	0	3	4	1	4	3	4	4	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:46239901C>T	uc002ini.1	-	11	1020	c.908G>A	c.(907-909)TGG>TAG	p.W303*	SKAP1_uc002inj.1_Nonsense_Mutation_p.W302*|SKAP1_uc010dbd.1_Nonsense_Mutation_p.W208*|SKAP1_uc010dbe.1_Nonsense_Mutation_p.W303*	NM_003726	NP_003717	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1 isoform	303	SH3.				positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0						ATGGCAATCCCATAGGCCCTG	0.463													12	70					0	0	0	0	T	46239901	T	T	46239901	4	4	239	1	0	0	0	0	0	1	0	0	14420	595	21	4	179	4	SKAP1	17	46239901	Nonsense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	3991665	46239901	34955309	197	43830											
HOXB2	3212	broad.mit.edu	37	chr17	46620658	46620658	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgggctccagcccgccggcCccgcgcagcgcgcagccggg	3	1	16	21	8	0	0	0	0	0	0	1	0	1	0	7	3	3	3	7	3	0	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:46620658C>T	uc002inm.2	-	2	963	c.843G>A	c.(841-843)GGG>GGA	p.G281G		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	281					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCCGCCGGCCCCGCGCAGCG	0.711													9	48					0	0	0	0	T	46620658	T	T	46620658	2	4	239	1	0	0	0	0	0	0	0	1	7340	610	22	4		4	HOXB2	17	46620658	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	380757	46620658	34574552	198	43831											
CA10	56934	broad.mit.edu	37	chr17	49726560	49726560	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttttatatgttattcttGtgatagtatctctgttgagc	8	21	7	5	0	2	2	0	2	2	0	3	2	2	2	0	0	2	3	0	0	6	10			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:49726560G>C	uc002itw.3	-	6	1603	c.617C>G	c.(616-618)ACA>AGA	p.T206R	CA10_uc002itu.3_Missense_Mutation_p.T135R|CA10_uc002itv.3_Missense_Mutation_p.T212R|CA10_uc002itx.3_Missense_Mutation_p.T206R|CA10_uc002ity.3_Missense_Mutation_p.T206R|CA10_uc002itz.2_Missense_Mutation_p.T206R	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	206					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGTTATTCTTGTGATAGTATC	0.284													5	62					0	0	0	0	C	49726560	C	C	49726560	3	2	239	1	0	0	0	0	1	0	0	0	2523	1377	48	4	385	4	CA10	17	49726560	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	3105902	49726560	31468650	199	43832											
SCPEP1	59342	broad.mit.edu	37	chr17	55072947	55072947	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgccgtaaataaggggctctAcagagaggccacagagctgt	12	7	13	9	1	1	2	0	0	1	2	1	3	1	2	2	3	3	3	2	3	4	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:55072947A>G	uc002iuv.3	+	8	790	c.737A>G	c.(736-738)TAC>TGC	p.Y246C	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Missense_Mutation_p.Y196C	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	246					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					AAGGGGCTCTACAGAGAGGCC	0.498													6	118					0	0	0	0	G	55072947	G	G	55072947	3	3	239	1	0	0	0	0	1	0	0	0	14000	391	14	5	767	5	SCPEP1	17	55072947	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	5346387	55072947	26122263	200	43833											
TTYH2	94015	broad.mit.edu	37	chr17	72233624	72233624	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggagctgaccaagctatcCgaccagactggctacgtgga	11	7	12	11	2	0	2	0	1	0	1	1	5	1	4	3	3	3	3	3	3	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:72233624C>T	uc002jkc.2	+	4	637	c.606C>T	c.(604-606)TCC>TCT	p.S202S	TTYH2_uc010wqw.1_Silent_p.S181S	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	202	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						CCAAGCTATCCGACCAGACTG	0.572													7	64					0	0	0	0	T	72233624	T	T	72233624	2	4	239	1	0	0	0	0	0	0	0	1	16808	639	23	1		1	TTYH2	17	72233624	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	17160677	72233624	8961586	201	43834											
DNAI2	64446	broad.mit.edu	37	chr17	72285736	72285736	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccctctcccctgcagggaCccccaggaaatcaagagggc	9	6	10	16	0	2	1	1	0	1	1	4	3	3	3	5	3	1	1	5	3	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:72285736C>T	uc002jkf.2	+	5	570	c.471C>T	c.(469-471)GAC>GAT	p.D157D	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	157					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CCTGCAGGGACCCCCAGGAAA	0.483									Kartagener_syndrome				22	34					0	0	0	0	T	72285736	T	T	72285736	2	4	239	1	0	0	0	0	0	0	0	1	4632	506	18	4		4	DNAI2	17	72285736	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	52112	72285736	8909474	202	43835											
PGS1	9489	broad.mit.edu	37	chr17	76396892	76396892	+	Frame_Shift_Del	DEL	A	-	-																															gtccctgcagctgcagggggAcgacacggtgcaggtggtgg																										TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:76396892delA	uc002jvm.2	+	6	848	c.836delA	c.(835-837)GACfs	p.D279fs	PGS1_uc010wtt.1_RNA|PGS1_uc010dho.2_RNA|PGS1_uc002jvn.2_5'UTR|PGS1_uc002jvo.2_RNA|PGS1_uc002jvp.1_5'UTR	NM_024419	NP_077733	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	279					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			CTGCAGGGGGACGACACGGTG	0.637													---	---	---								-	76396892	-	-	76396892	7	5	239	1	0	1	0	1	0	0	0	0	11863	275	10	0	858	0	PGS1	17	76396892	Frame_Shift_Del	DEL	A	TCGA-CV-7250-01A-11D-2012-08	4111156	76396892	4798318	203	43836											
CCDC40	55036	broad.mit.edu	37	chr17	78055742	78055742	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagggcgagctggagctcaGgaggaagacggatgctgcca	10	4	17	10	2	1	1	1	0	0	1	1	6	1	5	2	5	4	3	2	5	1	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:78055742G>T	uc010dht.2	+	12	1901	c.1874G>T	c.(1873-1875)AGG>ATG	p.R625M	CCDC40_uc002jxm.3_Missense_Mutation_p.R408M|CCDC40_uc002jxn.3_Missense_Mutation_p.R21M	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	625	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CTGGAGCTCAGGAGGAAGACG	0.577													9	36					3.09899e-07	1.22983e-06	1	0	T	78055742	T	T	78055742	3	4	239	1	0	0	0	0	1	0	0	0	2825	1000	35	4	1920	4	CCDC40	17	78055742	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	1658850	78055742	3139468	204	43837											
EPB41L3	23136	broad.mit.edu	37	chr18	5415995	5415995	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaacagggcacaagggacGgtgagcggatcgggaggtaa	13	3	19	6	3	0	1	0	1	0	0	1	5	0	5	0	7	2	2	0	7	3	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr18:5415995G>A	uc002kmt.1	-	13	1975	c.1889C>T	c.(1888-1890)CCG>CTG	p.P630L	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Intron|EPB41L3_uc010wzf.1_Intron|EPB41L3_uc010wzg.1_Intron|EPB41L3_uc010dkr.2_Intron	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	630	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CACAAGGGACGGTGAGCGGAT	0.542													18	59					0	0	0	0	A	5415995	A	A	5415995	3	1	239	1	0	0	0	0	1	0	0	0	5178	1116	39	1	1414	1	EPB41L3	18	5415995	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08		5415995	72661253	205	43838											
ANKRD30B	374860	broad.mit.edu	37	chr18	14797798	14797798	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagcctacctgtggaaggaaAgtttctcttccaaataaagc	13	11	8	9	0	1	0	0	0	1	0	3	2	2	2	3	2	3	1	3	2	7	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr18:14797798A>G	uc010dlo.2	+	20	2154	c.1974A>G	c.(1972-1974)AAA>AAG	p.K658K	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	658										ovary(1)|skin(1)	2						GTGGAAGGAAAGTTTCTCTTC	0.279													2	1					0	0	0	0	G	14797798	G	G	14797798	2	3	239	1	0	0	0	0	0	0	0	1	659	69	3	5		5	ANKRD30B	18	14797798	Silent	SNP	A	TCGA-CV-7250-01A-11D-2012-08	9381803	14797798	63279450	206	43839											
NOL4	8715	broad.mit.edu	37	chr18	31432903	31432903	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caacaagctgtctcacggcaTtgatttcagttggactcagc	10	11	9	11	1	3	1	3	1	1	0	4	2	3	2	0	2	3	3	0	2	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr18:31432903T>C	uc010dmi.2	-	11	2049	c.1820A>G	c.(1819-1821)AAT>AGT	p.N607S	NOL4_uc010xbs.1_Missense_Mutation_p.N322S|NOL4_uc002kxr.3_Missense_Mutation_p.N379S|NOL4_uc010xbt.1_Missense_Mutation_p.N533S|NOL4_uc010dmh.2_Missense_Mutation_p.N469S|NOL4_uc010xbu.1_Missense_Mutation_p.N543S|NOL4_uc002kxt.3_Missense_Mutation_p.N505S	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	607						nucleolus	RNA binding			ovary(3)	3						TCTCACGGCATTGATTTCAGT	0.468													25	49					0	0	0	0	C	31432903	C	C	31432903	3	2	239	1	0	0	0	0	1	0	0	0	10578	1493	52	5	100	5	NOL4	18	31432903	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	16635105	31432903	46644345	207	43840											
TSHZ1	10194	broad.mit.edu	37	chr18	73000493	73000493	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaatgtaagctctgcaaccGgacttttgcgagcaagcacg	11	8	10	12	3	1	0	0	0	1	0	1	2	1	1	2	1	6	5	2	1	4	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr18:73000493G>A	uc002lly.2	+	2	3559	c.2996G>A	c.(2995-2997)CGG>CAG	p.R999Q		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	1044	C2H2-type 5.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CTCTGCAACCGGACTTTTGCG	0.532													24	53					0	0	0	0	A	73000493	A	A	73000493	3	1	239	1	0	0	0	0	1	0	0	0	16690	1116	39	1	2998	1	TSHZ1	18	73000493	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	41567590	73000493	5076755	208	43841											
APC2	10297	broad.mit.edu	37	chr19	1467216	1467216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggcctgccccgagcgcggcGggggcgccgggggcgccggc	1	1	22	17	9	0	0	0	0	0	0	0	1	0	0	5	7	2	0	5	7	0	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:1467216G>A	uc002lsr.1	+	15	4124	c.3916G>A	c.(3916-3918)GGG>AGG	p.G1306R	APC2_uc002lss.1_Missense_Mutation_p.G888R|APC2_uc002lst.1_Missense_Mutation_p.G1306R|APC2_uc002lsu.1_Missense_Mutation_p.G1305R|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1306	Interaction with CTNNB1.|5 X 20 AA approximate repeat of F-X-V-E- X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGAgcgcggcgggggcgccgg	0.642													4	11					0	0	0	0	A	1467216	A	A	1467216	3	1	239	1	0	0	0	0	1	0	0	0	764	1116	39	1	3970	1	APC2	19	1467216	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08		1467216	57661767	209	43842											
SNAPC2	6618	broad.mit.edu	37	chr19	7986386	7986386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgcatccgggtggccttcagGgaccaaggcgccgggaggca	7	5	17	12	3	1	0	1	0	0	0	2	2	2	2	4	6	1	2	4	6	1	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:7986386G>A	uc002miw.1	+	2	285	c.262G>A	c.(262-264)GGA>AGA	p.G88R	SNAPC2_uc002mix.1_RNA	NM_003083	NP_003074	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex,	88					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity				0						TGGCCTTCAGGGACCAAGGCG	0.657													21	36					0	0	0	0	A	7986386	A	A	7986386	3	1	239	1	0	0	0	0	1	0	0	0	14899	1233	43	4	268	4	SNAPC2	19	7986386	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	6519170	7986386	51142597	210	43843											
SMARCA4	6597	broad.mit.edu	37	chr19	11105592	11105592	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatccagaagctgaccaaggCagtggccacgtaccatgcca	13	5	10	13	1	0	2	0	1	0	1	1	2	1	2	5	2	3	3	5	2	4	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:11105592C>A	uc002mqf.3	+	9	1792	c.1508C>A	c.(1507-1509)GCA>GAA	p.A503E	SMARCA4_uc010dxp.2_Missense_Mutation_p.A503E|SMARCA4_uc010dxo.2_Missense_Mutation_p.A503E|SMARCA4_uc002mqg.1_Missense_Mutation_p.A503E|SMARCA4_uc010dxq.2_Missense_Mutation_p.A503E|SMARCA4_uc010dxr.2_Missense_Mutation_p.A503E|SMARCA4_uc002mqj.3_Missense_Mutation_p.A503E|SMARCA4_uc010dxs.2_Missense_Mutation_p.A503E|SMARCA4_uc002mqe.2_Missense_Mutation_p.A503E	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	503	HSA.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTGACCAAGGCAGTGGCCACG	0.532			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				4	21					3.86212e-05	0.000146906	1	0	A	11105592	A	A	11105592	3	1	239	1	0	0	0	0	1	0	0	0	14834	710	25	4	1538	4	SMARCA4	19	11105592	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	3119206	11105592	48023391	211	43844											
SMARCA4	6597	broad.mit.edu	37	chr19	11141507	11141507	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcacccgggctggggggctcGgcctgaacctccagtcggca	5	5	16	15	3	0	1	0	1	0	0	3	1	1	1	4	6	1	4	4	6	1	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:11141507G>T	uc002mqf.3	+	25	3768	c.3484G>T	c.(3484-3486)GGC>TGC	p.G1162C	SMARCA4_uc010dxp.2_Missense_Mutation_p.G1162C|SMARCA4_uc010dxo.2_Missense_Mutation_p.G1162C|SMARCA4_uc002mqg.1_Missense_Mutation_p.G1162C|SMARCA4_uc010dxq.2_Missense_Mutation_p.G1162C|SMARCA4_uc010dxr.2_Missense_Mutation_p.G1162C|SMARCA4_uc002mqj.3_Missense_Mutation_p.G1162C|SMARCA4_uc010dxs.2_Missense_Mutation_p.G1162C|SMARCA4_uc010dxt.1_Missense_Mutation_p.G382C|SMARCA4_uc002mqh.3_Missense_Mutation_p.G285C|SMARCA4_uc002mqi.1_Missense_Mutation_p.G365C	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1162	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TGGGGGGCTCGGCCTGAACCT	0.607			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				6	7					3.59834e-05	0.00013844	1	0	T	11141507	T	T	11141507	3	4	239	1	0	0	0	0	1	0	0	0	14834	1116	39	3	3578	3	SMARCA4	19	11141507	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	35915	11141507	47987476	212	43845											
ZNF844	284391	broad.mit.edu	37	chr19	12187076	12187076	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcccagttcgttttgaaGacatgaaagaactcacactg	12	12	7	10	1	2	4	1	2	1	2	4	4	2	4	1	0	1	2	1	0	3	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:12187076G>C	uc002mtb.2	+	4	1284	c.1141G>C	c.(1141-1143)GAC>CAC	p.D381H	ZNF844_uc010dym.1_Missense_Mutation_p.D224H	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	381					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCGTTTTGAAGACATGAAAGA	0.383													7	21					0	0	0	0	C	12187076	C	C	12187076	3	2	239	1	0	0	0	0	1	0	0	0	18257	942	33	2	1155	2	ZNF844	19	12187076	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	1045569	12187076	46941907	213	43846											
ZNF486	90649	broad.mit.edu	37	chr19	20308131	20308131	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actacacataaaaaaattgaTactggagagaaaccatacaa	22	7	5	7	0	0	2	0	1	0	1	0	4	0	3	1	1	4	0	1	1	9	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:20308131T>C	uc002nou.2	+	4	669	c.612T>C	c.(610-612)GAT>GAC	p.D204D		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAAAAATTGATACTGGAGAGA	0.358													18	38					0	0	0	0	C	20308131	C	C	20308131	2	2	239	1	0	0	0	0	0	0	0	1	18006	1403	49	5		5	ZNF486	19	20308131	Silent	SNP	T	TCGA-CV-7250-01A-11D-2012-08	8121055	20308131	38820852	214	43847											
ZNF568	374900	broad.mit.edu	37	chr19	37441482	37441482	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggagagaaaccttatgaatGcagtgaatgtgggaaagctt	14	10	13	4	0	0	3	0	2	0	1	0	6	0	5	1	2	3	2	1	2	5	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:37441482G>A	uc002ofc.2	+	7	1942	c.1427G>A	c.(1426-1428)TGC>TAC	p.C476Y	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.C400Y|ZNF568_uc010efe.2_Missense_Mutation_p.C400Y|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	476	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCTTATGAATGCAGTGAATGT	0.393													20	61					0	0	0	0	A	37441482	A	A	37441482	3	1	239	1	0	0	0	0	1	0	0	0	18066	1319	46	4	1445	4	ZNF568	19	37441482	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	17133351	37441482	21687501	215	43848											
ZNF585B	92285	broad.mit.edu	37	chr19	37677286	37677286	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggctctcccacagtcacTgcattcataaggtttctctc	9	12	7	13	0	4	0	2	0	2	0	7	1	4	0	1	2	1	3	1	2	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:37677286T>A	uc002ofq.2	-	5	1407	c.1153A>T	c.(1153-1155)AGT>TGT	p.S385C	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.S199C	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	385	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCACAGTCACTGCATTCATAA	0.428													10	56					0	0	0	0	A	37677286	A	A	37677286	3	1	239	1	0	0	0	0	1	0	0	0	18085	1580	55	5	1160	5	ZNF585B	19	37677286	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	235804	37677286	21451697	216	43849											
SIPA1L3	23094	broad.mit.edu	37	chr19	38652910	38652910	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagagcctttgtggcatgtgCctgcccaggccaggctctca	6	9	12	14	0	1	1	1	0	1	1	2	1	1	1	4	3	3	2	4	3	0	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:38652910C>G	uc002ohk.2	+	14	4188	c.3679C>G	c.(3679-3681)CCT>GCT	p.P1227A		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1227					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GTGGCATGTGCCTGCCCAGGC	0.582													4	51					0	0	0	0	G	38652910	G	G	38652910	3	3	239	1	0	0	0	0	1	0	0	0	14396	739	26	4	3725	4	SIPA1L3	19	38652910	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	975624	38652910	20476073	217	43850											
SERTAD1	29950	broad.mit.edu	37	chr19	40929342	40929342	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggagctagaggccacggccgGgggtgcctgtgccaccgctg	5	5	18	13	3	0	1	0	0	0	1	0	2	0	2	5	5	3	2	5	5	1	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:40929342G>A	uc002ont.3	-	2	271	c.112C>T	c.(112-114)CCG>TCG	p.P38S		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	38	SERTA.				positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCCACGGCCGGGGGTGCCTGT	0.647													12	21					0	0	0	0	A	40929342	A	A	40929342	3	1	239	1	0	0	0	0	1	0	0	0	14185	1232	43	4	602	4	SERTAD1	19	40929342	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	2276432	40929342	18199641	218	43851											
PSG7	5676	broad.mit.edu	37	chr19	43433722	43433722	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgttggtttcagacagcTgcaagctgtgagtcataggg	8	12	13	8	0	2	2	2	1	0	1	3	2	3	2	1	2	3	5	1	2	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:43433722T>A	uc002ovl.3	-	4	683	c.581A>T	c.(580-582)CAG>CTG	p.Q194L	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_5'Flank|PSG7_uc002out.1_Missense_Mutation_p.Q13L|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.Q72L	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	194	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TTCAGACAGCTGCAAGCTGTG	0.512													138	254					0	0	0	0	A	43433722	A	A	43433722	3	1	239	1	0	0	0	0	1	0	0	0	12722	1580	55	5	694	5	PSG7	19	43433722	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	2504380	43433722	15695261	219	43852											
PRR12	57479	broad.mit.edu	37	chr19	50099588	50099588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acggcttggtgggcgaggacGgggcagcagatgcctctaag	8	6	18	9	3	1	1	0	0	1	1	1	3	1	2	1	6	2	3	1	6	1	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:50099588G>A	uc002poo.3	+	4	1996	c.1996G>A	c.(1996-1998)GGG>AGG	p.G666R		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGGCGAGGACGGGGCAGCAGA	0.672													4	11					0	0	0	0	A	50099588	A	A	50099588	3	1	239	1	0	0	0	0	1	0	0	0	12646	1116	39	1	2010	1	PRR12	19	50099588	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	6665866	50099588	9029395	220	43853											
SIGLEC9	27180	broad.mit.edu	37	chr19	51633226	51633226	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgcccgctcctcagtggggGaaggagagctccagtatgca	8	7	14	12	1	1	1	1	0	0	1	3	3	3	2	3	3	3	4	3	3	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:51633226G>T	uc002pvu.2	+	7	1349	c.1282G>T	c.(1282-1284)GAA>TAA	p.E428*	SIGLEC9_uc010yct.1_Intron	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	428	Cytoplasmic (Potential).				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CTCAGTGGGGGAAGGAGAGCT	0.607													9	77					0.000274275	0.00102777	1	0	T	51633226	T	T	51633226	4	4	239	1	0	0	0	0	0	1	0	0	14380	1175	41	2	1308	2	SIGLEC9	19	51633226	Nonsense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	1533638	51633226	7495757	221	43854											
ZNF808	388558	broad.mit.edu	37	chr19	53058290	53058290	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacagtggaatgaaaccttaCaagtgtaatgagtgcagcaa	16	8	10	7	0	0	2	0	2	0	0	0	3	0	3	1	1	4	3	1	1	6	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:53058290C>T	uc010epq.1	+	5	2298	c.2121C>T	c.(2119-2121)TAC>TAT	p.Y707Y	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	707	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TGAAACCTTACAAGTGTAATG	0.413													19	250					0	0	0	0	T	53058290	T	T	53058290	2	4	239	1	0	0	0	0	0	0	0	1	18240	489	17	4		4	ZNF808	19	53058290	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	1425064	53058290	6070693	222	43855											
VN1R2	317701	broad.mit.edu	37	chr19	53762612	53762612	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcacctttgcattatgttaCgccctttccttcatcaccta	8	15	4	14	1	2	0	2	0	0	0	3	0	3	0	4	0	3	3	4	0	3	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:53762612C>T	uc002qbi.2	+	1	1068	c.984C>T	c.(982-984)TAC>TAT	p.Y328Y		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	328	Helical; Name=6; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		CATTATGTTACGCCCTTTCCT	0.443													45	109					0	0	0	0	T	53762612	T	T	53762612	2	4	239	1	0	0	0	0	0	0	0	1	17247	547	19	1		1	VN1R2	19	53762612	Silent	SNP	C	TCGA-CV-7250-01A-11D-2012-08	704322	53762612	5366371	223	43856											
CACNG6	59285	broad.mit.edu	37	chr19	54496175	54496175	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaagaggagaaccggcggcGgggggccgcgggccggcggc	6	0	23	12	7	0	2	0	0	0	2	0	3	0	2	3	9	1	1	3	9	2	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:54496175G>C	uc002qct.2	+	1	634	c.44G>C	c.(43-45)CGG>CCG	p.R15P	CACNG6_uc002qcu.2_Missense_Mutation_p.R15P|CACNG6_uc002qcv.2_Missense_Mutation_p.R15P	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	15						voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		AAccggcggcggggggccgcg	0.562													8	17					0	0	0	0	C	54496175	C	C	54496175	3	2	239	1	0	0	0	0	1	0	0	0	2573	1116	39	3	46	3	CACNG6	19	54496175	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	733563	54496175	4632808	224	43857											
KIR2DL1	3802	broad.mit.edu	37	chr19	55294944	55294944	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccatcttctacagatgctgCggtaatggaccaagagtctg	10	11	10	10	1	3	2	0	0	3	2	4	3	4	3	2	2	3	2	2	2	3	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:55294944C>T	uc002qhb.1	+	7	862	c.824C>T	c.(823-825)GCG>GTG	p.A275V	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_5'Flank|KIR2DL3_uc010erw.1_Missense_Mutation_p.A276V|KIR2DL1_uc002qgz.1_Missense_Mutation_p.A185V|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.A301V	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	275	Cytoplasmic (Potential).				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		ACAGATGCTGCGGTAATGGAC	0.517													11	55					0	0	0	0	T	55294944	T	T	55294944	3	4	239	1	0	0	0	0	1	0	0	0	8355	768	27	1	850	1	KIR2DL1	19	55294944	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	798769	55294944	3834039	225	43858											
ZNF550	162972	broad.mit.edu	37	chr19	58058918	58058918	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcccacatgcattgcattCatagggtttcattccagtgt	8	16	7	10	0	2	0	2	0	0	0	4	0	4	0	2	1	2	3	2	1	1	6			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:58058918C>G	uc002qpe.1	-	2	571	c.571G>C	c.(571-573)GAA>CAA	p.E191Q	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF550_uc002qpc.2_RNA|ZNF550_uc010eue.1_RNA|ZNF550_uc002qpd.2_RNA	NM_001039654	NP_001034743	Q7Z398	ZN550_HUMAN	zinc finger protein 550	232	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCATTGCATTCATAGGGTTTC	0.488													16	38					0	0	0	0	G	58058918	G	G	58058918	3	3	239	1	0	0	0	0	1	0	0	0	18049	835	29	2	578	2	ZNF550	19	58058918	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	2763974	58058918	1070065	226	43859											
ZNF551	90233	broad.mit.edu	37	chr19	58198329	58198329	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttacaagtggggtgaatacaGaaaagcttcaagccacaaac	17	7	9	8	0	1	2	1	1	0	1	1	2	1	2	1	2	5	1	1	2	8	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:58198329G>A	uc002qpw.3	+	3	861	c.638G>A	c.(637-639)AGA>AAA	p.R213K	ZNF551_uc002qpv.3_Missense_Mutation_p.R156K|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGTGAATACAGAAAAGCTTCA	0.453													6	64					0	0	0	0	A	58198329	A	A	58198329	3	1	239	1	0	0	0	0	1	0	0	0	18050	942	33	2	648	2	ZNF551	19	58198329	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	139411	58198329	930654	227	43860											
PAK7	57144	broad.mit.edu	37	chr20	9561116	9561116	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccagaggggagctactcgaGgctctctgatactcccactt	8	10	10	13	1	1	2	0	1	1	1	5	4	3	3	2	3	3	2	2	3	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:9561116G>A	uc002wnl.2	-	5	1211	c.666C>T	c.(664-666)GCC>GCT	p.A222A	PAK7_uc002wnk.2_Silent_p.A222A|PAK7_uc002wnj.2_Silent_p.A222A|PAK7_uc010gby.1_Silent_p.A222A	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	222	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			AGCTACTCGAGGCTCTCTGAT	0.488													15	35					0	0	0	0	A	9561116	A	A	9561116	2	1	239	1	0	0	0	0	0	0	0	1	11459	987	35	4		4	PAK7	20	9561116	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08		9561116	53464404	228	43861											
RALGAPA2	57186	broad.mit.edu	37	chr20	20616166	20616166	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatccacttaataaaaacaaCacgagctgccatatatggaa	19	8	5	9	1	0	0	0	0	0	0	1	2	1	1	2	1	4	1	2	1	9	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:20616166C>T	uc002wrz.2	-	9	1044	c.901G>A	c.(901-903)GTT>ATT	p.V301I	RALGAPA2_uc010gcx.2_Missense_Mutation_p.V5I|RALGAPA2_uc010zsg.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	301					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						ATAAAAACAACACGAGCTGCC	0.358													6	121					0	0	0	0	T	20616166	T	T	20616166	3	4	239	1	0	0	0	0	1	0	0	0	13079	478	17	4	4844	4	RALGAPA2	20	20616166	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	11055050	20616166	42409354	229	43862											
NECAB3	63941	broad.mit.edu	37	chr20	32247476	32247476	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccttgcactcgagctggtCgatgagctcctggaggcggt	6	9	14	12	3	0	1	0	1	0	0	3	4	1	2	2	4	3	3	2	4	0	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:32247476C>T	uc002wzn.3	-	8	812	c.706G>A	c.(706-708)GAC>AAC	p.D236N	NECAB3_uc002wzl.2_Missense_Mutation_p.D15N|NECAB3_uc002wzm.3_Missense_Mutation_p.D236N|NECAB3_uc002wzo.3_RNA|NECAB3_uc002wzp.3_Missense_Mutation_p.D187N|NECAB3_uc002wzq.3_Missense_Mutation_p.D236N|NECAB3_uc002wzr.3_RNA|NECAB3_uc010geo.2_Missense_Mutation_p.D236N|C20orf144_uc002wzs.1_5'Flank	NM_031232	NP_112509	Q96P71	NECA3_HUMAN	N-terminal EF-hand calcium binding protein 3	236					antibiotic biosynthetic process|protein metabolic process|protein secretion|regulation of amyloid precursor protein biosynthetic process	endoplasmic reticulum membrane|Golgi cis cisterna|nucleus	calcium ion binding|oxidoreductase activity|protein binding			lung(1)	1						TCGAGCTGGTCGATGAGCTCC	0.706													4	9					0	0	0	0	T	32247476	T	T	32247476	3	4	239	1	0	0	0	0	1	0	0	0	10360	884	31	1	504	1	NECAB3	20	32247476	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	11631310	32247476	30778044	230	43863											
CEP250	11190	broad.mit.edu	37	chr20	34078580	34078580	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agacagaaatggaggccatcCaggcccagagggaagaagaa	17	2	14	8	0	0	5	0	0	0	5	1	7	1	7	3	4	0	0	3	4	4	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:34078580C>T	uc002xcm.2	+	22	3375	c.2704C>T	c.(2704-2706)CAG>TAG	p.Q902*	CEP250_uc010zve.1_Nonsense_Mutation_p.Q270*	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	902	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGAGGCCATCCAGGCCCAGAG	0.557													9	77					0	0	0	0	T	34078580	T	T	34078580	4	4	239	1	0	0	0	0	0	1	0	0	3267	595	21	4	2774	4	CEP250	20	34078580	Nonsense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	1831104	34078580	28946940	231	43864											
KIAA1755	85449	broad.mit.edu	37	chr20	36869729	36869729	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tagtctccctcgaagtcctgGctgaccacctcgtccatcct	6	11	7	17	2	1	1	0	1	1	0	7	2	4	1	6	1	0	1	6	1	2	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:36869729G>A	uc002xhy.1	-	3	1076	c.804C>T	c.(802-804)AGC>AGT	p.S268S	KIAA1755_uc002xhz.1_Silent_p.S268S	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	268										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				CGAAGTCCTGGCTGACCACCT	0.572													11	75					0	0	0	0	A	36869729	A	A	36869729	2	1	239	1	0	0	0	0	0	0	0	1	8296	1194	42	4		4	KIAA1755	20	36869729	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	2791149	36869729	26155791	232	43865											
JPH2	57158	broad.mit.edu	37	chr20	42815270	42815270	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcctgtgcacagtccatGcccatgggcctttcccccct	4	9	11	17	0	0	0	0	0	0	0	2	0	2	0	7	3	2	1	7	3	0	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:42815270G>T	uc002xli.1	-	1	949	c.76C>A	c.(76-78)CAT>AAT	p.H26N	JPH2_uc002xlj.2_Missense_Mutation_p.H26N	NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	26	MORN 1.|Gly-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CACAGTCCATGCCCATGGGCC	0.622													8	43					2.17888e-05	8.41497e-05	1	0	T	42815270	T	T	42815270	3	4	239	1	0	0	0	0	1	0	0	0	8000	1319	46	4	2049	4	JPH2	20	42815270	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	5945541	42815270	20210250	233	43866											
KRTAP19-7	337974	broad.mit.edu	37	chr21	31933565	31933565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggccaccgaatcctccaCagccgtagcctaggcctcca	9	5	8	19	2	0	0	0	0	0	0	3	1	3	0	9	2	2	1	9	2	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr21:31933565C>T	uc011adb.1	-	1	44	c.44G>A	c.(43-45)TGT>TAT	p.C15Y		NM_181614	NP_853645	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	15						intermediate filament					0						GAATCCTCCACAGCCGTAGCC	0.552													23	75					0	0	0	0	T	31933565	T	T	31933565	3	4	239	1	0	0	0	0	1	0	0	0	8573	478	17	4	150	4	KRTAP19-7	21	31933565	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08		31933565	16196330	234	43867											
CECR2	27443	broad.mit.edu	37	chr22	18031816	18031816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcataagcctccaacacttCccctggatcaggtaaggatc	11	9	7	14	0	2	0	2	0	0	0	5	2	4	2	4	3	2	1	4	3	3	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:18031816C>T	uc010gqw.1	+	17	4438	c.4312C>T	c.(4312-4314)CCC>TCC	p.P1438S	CECR2_uc010gqv.1_Missense_Mutation_p.P1296S|CECR2_uc002zml.2_Missense_Mutation_p.P1297S|CECR2_uc002zmo.2_RNA	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	1480					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		TCCAACACTTCCCCTGGATCA	0.498													12	32					0	0	0	0	T	18031816	T	T	18031816	3	4	239	1	0	0	0	0	1	0	0	0	3221	855	30	2	4380	2	CECR2	22	18031816	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08		18031816	33272750	235	43868											
PIWIL3	440822	broad.mit.edu	37	chr22	25131809	25131809	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtggcattgcattaagtaaGggtaattctcttatttctct	10	17	8	6	0	2	0	0	0	2	0	4	0	2	0	0	2	1	4	0	2	4	7			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:25131809G>A	uc003abd.1	-	13	1917	c.1500C>T	c.(1498-1500)CCC>CCT	p.P500P	PIWIL3_uc011ajx.1_Silent_p.P391P|PIWIL3_uc011ajy.1_Silent_p.P391P|PIWIL3_uc010gut.1_Silent_p.P500P	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	500					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						CATTAAGTAAGGGTAATTCTC	0.383													39	103					0	0	0	0	A	25131809	A	A	25131809	2	1	239	1	0	0	0	0	0	0	0	1	12014	987	35	4		4	PIWIL3	22	25131809	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	7099993	25131809	26172757	236	43869											
CCDC117	150275	broad.mit.edu	37	chr22	29169754	29169754	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacacaagcgagaggaggAggaggatgatgagtaagttt	16	6	16	3	1	0	3	0	2	0	1	0	9	0	7	0	4	2	2	0	4	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:29169754A>T	uc003aeb.2	+	2	403	c.227A>T	c.(226-228)GAG>GTG	p.E76V	CCDC117_uc011aki.1_Intron|CCDC117_uc011akj.1_Missense_Mutation_p.E76V|CCDC117_uc011akk.1_5'UTR	NM_173510	NP_775781	Q8IWD4	CC117_HUMAN	coiled-coil domain containing 117	76										breast(1)	1						CGAGAGGAGGAGGAGGATGAT	0.373													9	11					0	0	0	0	T	29169754	T	T	29169754	3	4	239	1	0	0	0	0	1	0	0	0	2766	304	11	5	233	5	CCDC117	22	29169754	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	4037945	29169754	22134812	237	43870											
TAB1	10454	broad.mit.edu	37	chr22	39772188	39772188	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcgccttctcctttttcTccatcttcacctgggtgagt	4	16	6	15	1	4	1	1	1	3	0	7	1	4	1	5	1	0	0	5	1	0	4			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:39772188T>G	uc003axr.2	+	2	2029	c.247T>G	c.(247-249)TCC>GCC	p.S83A	SYNGR1_uc003axo.3_Missense_Mutation_p.S157A|SYNGR1_uc003axp.3_Missense_Mutation_p.L123R|SYNGR1_uc003axq.3_Missense_Mutation_p.S157A|SYNGR1_uc003axs.3_Missense_Mutation_p.S158A	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	7					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						CTCCTTTTTCTCCATCTTCAC	0.637													35	51					0	0	0	0	G	39772188	G	G	39772188	3	3	239	1	0	0	0	0	1	0	0	0	15561	1551	54	5		5	TAB1	22	39772188	Missense_Mutation	SNP	T	TCGA-CV-7250-01A-11D-2012-08	10602434	39772188	11532378	238	43871											
CERK	64781	broad.mit.edu	37	chr22	47103761	47103761	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcgggaatgattccaatccGgaggctactggggaccagca	10	7	14	10	2	0	1	0	1	0	0	2	4	2	4	3	5	3	2	3	5	3	2			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:47103761G>A	uc003bia.2	-	6	801	c.694C>T	c.(694-696)CGG>TGG	p.R232W	CERK_uc010hae.2_Missense_Mutation_p.R34W	NM_022766	NP_073603	Q8TCT0	CERK1_HUMAN	ceramide kinase	232	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			skin(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ATTCCAATCCGGAGGCTACTG	0.602													16	109					0	0	0	0	A	47103761	A	A	47103761	3	1	239	1	0	0	0	0	1	0	0	0	3282	1115	39	1	951	1	CERK	22	47103761	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	7331573	47103761	4200805	239	43872											
MAPK11	5600	broad.mit.edu	37	chr22	50705870	50705870	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcgcctggcacttgacgAtgttgttcaggtcggcgccc	5	10	13	13	4	2	1	2	1	0	0	3	2	2	1	2	3	1	3	2	3	0	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:50705870A>T	uc003bkr.2	-	4	405	c.347T>A	c.(346-348)ATC>AAC	p.I116N	MAPK11_uc010hax.2_5'UTR|MAPK11_uc011ars.1_RNA|MAPK11_uc010hay.1_RNA|MAPK11_uc011art.1_Missense_Mutation_p.H96Q|MAPK11_uc010haz.2_Missense_Mutation_p.I8N	NM_002751	NP_002742	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	116	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			lung(1)|breast(1)	2		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCACTTGACGATGTTGTTCAG	0.682													9	12					0	0	0	0	T	50705870	T	T	50705870	3	4	239	1	0	0	0	0	1	0	0	0	9326	333	12	5	783	5	MAPK11	22	50705870	Missense_Mutation	SNP	A	TCGA-CV-7250-01A-11D-2012-08	3602109	50705870	598696	240	43873											
MAGEB18	286514	broad.mit.edu	37	chrX	26157205	26157205	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcaggccactgtggcagaaGgagagtcaccctcccctgcc	8	5	12	16	1	1	2	1	0	0	2	2	3	2	2	5	3	1	2	5	3	1	0			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:26157205G>A	uc004dbq.1	+	2	290	c.103G>A	c.(103-105)GGA>AGA	p.G35R		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	35							protein binding			central_nervous_system(1)	1						TGTGGCAGAAGGAGAGTCACC	0.587													5	15					0	0	0	0	A	26157205	A	A	26157205	3	1	239	1	0	0	0	0	1	0	0	0	9228	1001	35	4	105	4	MAGEB18	23	26157205	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08		26157205	129113355	241	43874											
CASK	8573	broad.mit.edu	37	chrX	41390289	41390289	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgtccagtattgcaatcaGcccctgctcgtggatcttcc	7	11	8	15	2	2	0	1	0	1	0	5	1	4	1	4	1	3	3	4	1	2	3			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:41390289G>A	uc004dfl.3	-	25	2522	c.2476C>T	c.(2476-2478)CTG>TTG	p.L826L	CASK_uc004dfj.3_Silent_p.L371L|CASK_uc004dfk.3_Silent_p.L646L|CASK_uc004dfm.3_Silent_p.L803L|CASK_uc004dfn.3_Silent_p.L802L	NM_003688	NP_003679	O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein	831	Guanylate kinase-like.				cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			ovary(3)|lung(2)|stomach(1)	6						ATTGCAATCAGCCCCTGCTCG	0.512													28	12					0	0	0	0	A	41390289	A	A	41390289	2	1	239	1	0	0	0	0	0	0	0	1	2677	962	34	4		4	CASK	23	41390289	Silent	SNP	G	TCGA-CV-7250-01A-11D-2012-08	15233084	41390289	113880271	242	43875											
TCEAL2	140597	broad.mit.edu	37	chrX	101382277	101382277	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatataaggaagccatacatGatatgaatttcagcaatgag	18	10	8	5	0	1	3	1	3	0	0	1	4	1	4	1	1	3	1	1	1	8	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:101382277G>T	uc004eip.2	+	3	694	c.475G>T	c.(475-477)GAT>TAT	p.D159Y		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AGCCATACATGATATGAATTT	0.428													11	58					1.33987e-11	5.62746e-11	1	0	T	101382277	T	T	101382277	3	4	239	1	0	0	0	0	1	0	0	0	15737	1290	45	2	477	2	TCEAL2	23	101382277	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	59991988	101382277	53888283	243	43876											
TEX13A	56157	broad.mit.edu	37	chrX	104464103	104464103	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctccttctgcccccaatagGtgtacttttcctgatcagca	7	13	6	15	0	2	1	1	1	1	0	4	1	4	1	5	1	3	2	5	1	3	5			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:104464103G>T	uc004ema.2	-	5	885	c.773C>A	c.(772-774)ACC>AAC	p.T258N	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.P259T	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	258						intracellular	zinc ion binding			ovary(2)	2						CCCCCAATAGGTGTACTTTTC	0.562													15	5					1.15088e-07	4.58531e-07	1	0	T	104464103	T	T	104464103	3	4	239	1	0	0	0	0	1	0	0	0	15842	1261	44	4	460	4	TEX13A	23	104464103	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	3081826	104464103	50806457	244	43877											
GPR119	139760	broad.mit.edu	37	chrX	129518927	129518927	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcaggagagggtcagcacGaagtgagggtgaaatacagc	14	4	16	7	2	1	3	1	2	0	1	1	5	1	3	0	3	3	2	0	3	3	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:129518927G>T	uc011muv.1	-	1	495	c.495C>A	c.(493-495)TTC>TTA	p.F165L		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	165	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						GGGTCAGCACGAAGTGAGGGT	0.532													21	13					2.54575e-18	1.12549e-17	1	0	T	129518927	T	T	129518927	3	4	239	1	0	0	0	0	1	0	0	0	6672	1049	37	3	516	3	GPR119	23	129518927	Missense_Mutation	SNP	G	TCGA-CV-7250-01A-11D-2012-08	25054824	129518927	25751633	245	43878											
FLNA	2316	broad.mit.edu	37	chrX	153588903	153588903	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccttggtgtcgatggtgaagCgggcgggggagcccgcactg	5	7	19	10	4	0	1	0	1	0	0	1	3	0	2	2	5	2	1	2	5	1	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:153588903C>T	uc004fkk.2	-	22	3509	c.3260G>A	c.(3259-3261)CGC>CAC	p.R1087H	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Missense_Mutation_p.R1087H	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1087	Filamin 9.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GATGGTGAAGCGGGCGGGGGA	0.692											OREG0003593	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	5	14					0	0	0	0	T	153588903	T	T	153588903	3	4	239	1	0	0	0	0	1	0	0	0	5965	768	27	1	4791	1	FLNA	23	153588903	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08	24069976	153588903	1681657	246	43879											
TSPY1	7258	broad.mit.edu	37	chrY	9305927	9305927	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aggtgggagaagagaagcatCctgttcatctctgcaagatc	12	9	12	8	0	2	3	1	0	1	3	5	5	3	3	1	2	2	3	1	2	3	1			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrY:9305927C>G	uc004frw.3	+	3	629	c.583C>G	c.(583-585)CCT>GCT	p.P195A	TSPY1_uc004frx.3_Missense_Mutation_p.P195A|TSPY1_uc010nwp.1_Intron	NM_003308	NP_003299	Q01534	TSPY1_HUMAN	testis specific protein, Y-linked 1	195			P -> R.		cell differentiation|cell proliferation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus	identical protein binding				0						AGAGAAGCATCCTGTTCATCT	0.443													20	139					0	0	0	0	G	9305927	G	G	9305927	3	3	239	1	0	0	0	0	1	0	0	0	16724	855	30	2	593	2	TSPY1	24	9305927	Missense_Mutation	SNP	C	TCGA-CV-7250-01A-11D-2012-08		9305927	50067639	247	43880											
DVL1	1855	broad.mit.edu	37	chr1	1273500	1273500	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcagccgggtggggcagcGgggccagcgtgtcctgatcc	4	5	20	12	3	0	1	0	1	0	0	2	1	2	1	4	6	3	2	4	6	0	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:1273500G>A	uc001aer.3	-	14	1543	c.1496C>T	c.(1495-1497)CCG>CTG	p.P499L	DVL1_uc002quu.2_Missense_Mutation_p.P241L|DVL1_uc009vka.2_Missense_Mutation_p.P182L|DVL1_uc001aeu.1_Missense_Mutation_p.P258L	NM_004421	NP_004412	O14640	DVL1_HUMAN	dishevelled 1	524					canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GTGGGGCAGCGGGGCCAGCGT	0.721													7	16					0	0	0	0	A	1273500	A	A	1273500	3	1	240	1	0	0	0	0	1	0	0	0	4857	1116	39	1	524	1	DVL1	1	1273500	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08		1273500	247977121	1	43881											
PTCHD2	57540	broad.mit.edu	37	chr1	11579445	11579445	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcagccggaagacctccctGcacttccccggagacgtgtt	7	8	11	15	3	0	2	0	0	0	2	2	4	2	3	5	2	3	3	5	2	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:11579445G>T	uc001ash.3	+	8	2061	c.1923G>T	c.(1921-1923)CTG>CTT	p.L641L	PTCHD2_uc001asi.1_Silent_p.L641L	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	641	Cytoplasmic (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AGACCTCCCTGCACTTCCCCG	0.652													55	159					7.06795e-37	2.5978e-36	1	0	T	11579445	T	T	11579445	2	4	240	1	0	0	0	0	0	0	0	1	12795	1306	46	4		4	PTCHD2	1	11579445	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	10305945	11579445	237671176	2	43882											
EPHA2	1969	broad.mit.edu	37	chr1	16456829	16456829	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgggcacgctcctgctgcCagcactgcatcatgagctgg	6	7	14	14	2	1	1	1	1	0	0	2	1	2	1	2	3	5	6	2	3	0	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:16456829C>T	uc001aya.1	-	15	2698	c.2561G>A	c.(2560-2562)TGG>TAG	p.W854*		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	854	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.|Cytoplasmic (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CTCCTGCTGCCAGCACTGCAT	0.612													16	51					0	0	0	0	T	16456829	T	T	16456829	4	4	240	1	0	0	0	0	0	1	0	0	5191	595	21	4	381	4	EPHA2	1	16456829	Nonsense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	4877384	16456829	232793792	3	43883											
EPHA2	1969	broad.mit.edu	37	chr1	16475160	16475161	+	Frame_Shift_Ins	INS	-	A	A																															gatatcctggaaggccaggtINSagaagcctttgcgggtgagc																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:16475160_16475161insA	uc001aya.1	-	3	672_673	c.535_536insT	c.(535-537)TACfs	p.Y179fs	EPHA2_uc010oca.1_Frame_Shift_Ins_p.Y179fs	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	179	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GAAGGCCAGGTAGAAGCCTTTG	0.644													---	---	---								A	16475161	A	A	16475160	7	5	240	1	0	1	1	0	0	0	0	0	5191	1638	57	0	2454	0	EPHA2	1	16475160	Frame_Shift_Ins	INS	-	TCGA-CV-7252-01A-11D-2012-08	18331	16475160	232775461	4	43884											
KIF17	57576	broad.mit.edu	37	chr1	21031314	21031314	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccgctcgcccgtggccccgGtcttggactgccgctcgctg	1	8	14	18	6	1	0	0	0	1	0	3	1	1	1	5	3	1	3	5	3	0	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:21031314G>A	uc001bdr.3	-	5	867	c.749C>T	c.(748-750)ACC>ATC	p.T250I	KIF17_uc001bds.3_Missense_Mutation_p.T250I	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	250	Kinesin-motor.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CGTGGCCCCGGTCTTGGACTG	0.667													11	78					0	0	0	0	A	21031314	A	A	21031314	3	1	240	1	0	0	0	0	1	0	0	0	8318	1261	44	4	2384	4	KIF17	1	21031314	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	4556154	21031314	228219307	5	43885											
ZBTB40	9923	broad.mit.edu	37	chr1	22816681	22816681	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgttggaaatgatgtacacGggcaaactacctgtgggcaa	12	10	12	7	1	0	1	0	1	0	0	0	2	0	2	1	3	3	4	1	3	5	4	rs138737436		TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:22816681G>A	uc001bft.2	+	3	751	c.240G>A	c.(238-240)ACG>ACA	p.T80T	ZBTB40_uc001bfu.2_Silent_p.T80T|ZBTB40_uc009vqi.1_Silent_p.T80T	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	80	BTB.				bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		TGATGTACACGGGCAAACTAC	0.463													9	60					0	0	0	0	A	22816681	A	A	22816681	2	1	240	1	0	0	0	0	0	0	0	1	17609	1103	39	1		1	ZBTB40	1	22816681	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1785367	22816681	226433940	6	43886											
C1orf172	126695	broad.mit.edu	37	chr1	27277199	27277199	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccataaggcctcagcttcCgggcgatggcatctgcagtc	7	9	11	14	2	2	0	1	0	1	0	5	1	4	0	3	3	2	3	3	3	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:27277199C>A	uc001bni.1	-	3	1177	c.1088G>T	c.(1087-1089)CGG>CTG	p.R363L		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	363										large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		CCTCAGCTTCCGGGCGATGGC	0.597													33	120					5.71845e-15	2.01075e-14	1	0	A	27277199	A	A	27277199	3	1	240	1	0	0	0	0	1	0	0	0	2022	652	23	3	116	3	C1orf172	1	27277199	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	4460518	27277199	221973422	7	43887											
C1orf172	126695	broad.mit.edu	37	chr1	27278782	27278783	+	Frame_Shift_Del	DEL	AT	-	-																															gggggctgaggtggtttatcAtatgtctccagacatagctc																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:27278782_27278783delAT	uc001bni.1	-	2	178_179	c.89_90delAT	c.(88-90)TATfs	p.Y30fs		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	30	Pro-rich.									large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GTGGTTTATCATATGTCTCCAG	0.629													---	---	---								-	27278783	-	-	27278782	7	5	240	1	0	1	0	1	0	0	0	0	2022	224	8	0	1118	0	C1orf172	1	27278782	Frame_Shift_Del	DEL	AT	TCGA-CV-7252-01A-11D-2012-08	1583	27278782	221971839	8	43888											
NT5C1A	84618	broad.mit.edu	37	chr1	40131889	40131889	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaggacacagcgatggtgActgcattctgaggcttgggc	8	8	17	8	1	1	2	0	2	1	0	1	5	1	4	0	5	2	2	0	5	0	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:40131889A>G	uc001cdq.1	-	2	155	c.155T>C	c.(154-156)GTC>GCC	p.V52A		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	52					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AGCGATGGTGACTGCATTCTG	0.592													7	36					0	0	0	0	G	40131889	G	G	40131889	3	3	240	1	0	0	0	0	1	0	0	0	10739	275	10	5	971	5	NT5C1A	1	40131889	Missense_Mutation	SNP	A	TCGA-CV-7252-01A-11D-2012-08	12853107	40131889	209118732	9	43889											
EBNA1BP2	10969	broad.mit.edu	37	chr1	43630439	43630439	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttctttccaccaaaacCaaacttctggtttttatacc	10	17	2	12	0	3	0	0	0	3	0	4	0	4	0	4	1	3	1	4	1	5	8			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:43630439C>A	uc001cin.2	-	8	942	c.745G>T	c.(745-747)GGT>TGT	p.G249C	EBNA1BP2_uc001cio.2_Missense_Mutation_p.G304C|EBNA1BP2_uc001cim.2_Missense_Mutation_p.G144C|EBNA1BP2_uc010ojx.1_Missense_Mutation_p.G304C	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	249					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCACCAAAACCAAACTTCTGG	0.483													19	60					1.15919e-05	3.80151e-05	1	0	A	43630439	A	A	43630439	3	1	240	1	0	0	0	0	1	0	0	0	4907	594	21	4	183	4	EBNA1BP2	1	43630439	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	3498550	43630439	205620182	10	43890											
ATP6V0B	533	broad.mit.edu	37	chr1	44441472	44441472	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tttctccctcactgctgcagGagtctgctacaccatttttg	6	15	7	13	0	3	0	1	0	2	0	4	1	3	1	2	1	4	3	2	1	1	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:44441472G>T	uc001cld.2	+	2	179	c.68G>T	c.(67-69)GGA>GTA	p.G23V	ATP6V0B_uc001clc.2_Missense_Mutation_p.G23V|ATP6V0B_uc001cle.2_Intron|ATP6V0B_uc001clf.2_5'UTR	NM_004047	NP_004038	Q99437	VATO_HUMAN	ATPase, H+ transporting, lysosomal 21kDa, V0	23	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transmembrane transporter activity			breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				ACTGCTGCAGGAGTCTGCTAC	0.552													49	171					4.32865e-36	1.585e-35	1	0	T	44441472	T	T	44441472	3	4	240	1	0	0	0	0	1	0	0	0	1173	1188	41	2	74	2	ATP6V0B	1	44441472	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	811033	44441472	204809149	11	43891											
C1orf168	199920	broad.mit.edu	37	chr1	57209833	57209833	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatgttacttacacctctttCctggagtactcgacatcatc	10	14	5	12	1	2	0	1	0	1	0	5	2	3	1	2	1	3	2	2	1	4	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:57209833C>T	uc001cym.3	-	10	1900	c.1494G>A	c.(1492-1494)AGG>AGA	p.R498R	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	498										ovary(3)|skin(2)	5						ACACCTCTTTCCTGGAGTACT	0.408													27	91					0	0	0	0	T	57209833	T	T	57209833	2	4	240	1	0	0	0	0	0	0	0	1	2021	854	30	2		2	C1orf168	1	57209833	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	12768361	57209833	192040788	12	43892											
DOCK7	85440	broad.mit.edu	37	chr1	62960063	62960063	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcttcagcatgattgcttcgTtctgagtgcttgcctgccat	5	15	10	11	1	2	2	1	2	1	0	3	2	2	2	2	0	5	5	2	0	0	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:62960063T>C	uc001daq.2	-	40	5107	c.5073A>G	c.(5071-5073)GAA>GAG	p.E1691E	DOCK7_uc001dan.2_Silent_p.E1552E|DOCK7_uc001dao.2_Silent_p.E1552E|DOCK7_uc001dap.2_Silent_p.E1669E|DOCK7_uc001dam.2_Silent_p.E871E|DOCK7_uc010oov.1_Silent_p.E430E	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1700	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						GATTGCTTCGTTCTGAGTGCT	0.478													17	56					0	0	0	0	C	62960063	C	C	62960063	2	2	240	1	0	0	0	0	0	0	0	1	4714	1722	60	5		5	DOCK7	1	62960063	Silent	SNP	T	TCGA-CV-7252-01A-11D-2012-08	5750230	62960063	186290558	13	43893											
CTH	1491	broad.mit.edu	37	chr1	70900825	70900825	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagctatttactctggccgaGagcttgggaggattcgaaag	10	11	13	7	2	1	1	0	0	1	1	2	5	1	3	1	3	3	2	1	3	4	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:70900825G>C	uc001dfd.2	+	10	1161	c.1017G>C	c.(1015-1017)GAG>GAC	p.E339D	CTH_uc001dfe.2_Missense_Mutation_p.E295D|CTH_uc010oqq.1_Missense_Mutation_p.E307D	NM_001902	NP_001893	P32929	CGL_HUMAN	cystathionase isoform 1	339		Substrate.			cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			lung(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CTCTGGCCGAGAGCTTGGGAG	0.289													7	20					0	0	0	0	C	70900825	C	C	70900825	3	2	240	1	0	0	0	0	1	0	0	0	4026	933	33	2	1055	2	CTH	1	70900825	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	7940762	70900825	178349796	14	43894											
GBP5	115362	broad.mit.edu	37	chr1	89729518	89729518	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcttagaataaattccctgCttcactgcttcttctagagg	9	14	8	10	0	3	2	1	0	2	2	4	2	4	2	1	2	2	3	1	2	5	7			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:89729518C>A	uc001dnc.2	-	9	1800	c.1263G>T	c.(1261-1263)AAG>AAT	p.K421N	GBP5_uc001dnd.2_Missense_Mutation_p.K421N|GBP5_uc001dne.1_Missense_Mutation_p.K421N	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	421						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		AAATTCCCTGCTTCACTGCTT	0.423													54	150					1.86277e-20	6.71977e-20	1	0	A	89729518	A	A	89729518	3	1	240	1	0	0	0	0	1	0	0	0	6312	796	28	4	513	4	GBP5	1	89729518	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	18828693	89729518	159521103	15	43895											
HFM1	164045	broad.mit.edu	37	chr1	91845680	91845680	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtaaacaattttaatattCaaccatggcaatggtacttc	14	14	5	8	0	1	0	1	0	0	0	2	0	1	0	1	2	3	3	1	2	8	7			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:91845680C>A	uc001doa.3	-	8	1087	c.987G>T	c.(985-987)TTG>TTT	p.L329F	HFM1_uc010osu.1_Missense_Mutation_p.L8F|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.L329F	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	329	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TTTTAATATTCAACCATGGCA	0.284													9	55					0.000274275	0.000887522	1	0	A	91845680	A	A	91845680	3	1	240	1	0	0	0	0	1	0	0	0	7122	825	29	2	3448	2	HFM1	1	91845680	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	2116162	91845680	157404941	16	43896											
CELSR2	1952	broad.mit.edu	37	chr1	109812163	109812163	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcagttccgcctgctggaGacagaggagcggaccaagcc	9	5	15	12	2	0	2	0	0	0	2	1	5	1	4	4	3	4	3	4	3	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:109812163G>A	uc001dxa.3	+	21	6991	c.6930G>A	c.(6928-6930)GAG>GAA	p.E2310E		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2310	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GCCTGCTGGAGACAGAGGAGC	0.607													16	73					0	0	0	0	A	109812163	A	A	109812163	2	1	240	1	0	0	0	0	0	0	0	1	3237	933	33	2		2	CELSR2	1	109812163	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	17966483	109812163	139438458	17	43897											
PDE4DIP	9659	broad.mit.edu	37	chr1	144879395	144879395	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgtcctttcgtaggaccAagatgttttctgactttcca	8	16	8	9	1	1	3	0	2	1	1	4	4	3	4	3	1	0	2	3	1	2	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	3ca6c16c-0424-4e47-82d0-9e25e253944b	g.chr1:144879395A>C	uc001elw.3	-	27	4346	c.4055T>G	c.(4054-4056)TTG>TGG	p.L1352W	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.L1308W|PDE4DIP_uc001elv.3_Missense_Mutation_p.L359W	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1352	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCGTAGGACCAAGATGTTTTC	0.517			T	PDGFRB	MPD								5	472					0	0	0	0	C	144879395	C	C	144879395	3	2	240	1	0	0	0	0	1	0	0	0	11697	131	5	5	3057	5	PDE4DIP	1	144879395	Missense_Mutation	SNP	A	TCGA-CV-7252-01A-11D-2012-08	35067232	144879395	104371226	18	43898											
KIAA0907	22889	broad.mit.edu	37	chr1	155903485	155903485	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatgagcatggcattaatcTtggcagccacagcagcagca	12	7	10	12	0	1	1	0	1	1	0	1	1	1	1	2	2	5	6	2	2	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:155903485T>C	uc001fmi.1	-	2	218	c.194A>G	c.(193-195)AAG>AGG	p.K65R	KIAA0907_uc001fmj.1_Missense_Mutation_p.K65R|KIAA0907_uc009wrk.1_Missense_Mutation_p.K65R|KIAA0907_uc009wrl.1_RNA|KIAA0907_uc001fml.1_Missense_Mutation_p.K65R|KIAA0907_uc001fmm.2_Missense_Mutation_p.K65R|KIAA0907_uc001fmo.2_Missense_Mutation_p.K65R	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	65											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			GGCATTAATCTTGGCAGCCAC	0.542													5	21					0	0	0	0	C	155903485	C	C	155903485	3	2	240	1	0	0	0	0	1	0	0	0	8238	1609	56	5	1702	5	KIAA0907	1	155903485	Missense_Mutation	SNP	T	TCGA-CV-7252-01A-11D-2012-08	11024090	155903485	93347136	19	43899											
PRCC	5546	broad.mit.edu	37	chr1	156756531	156756531	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggctcccctgatactaaGccctccagactggcttctaa	9	10	8	14	0	1	2	0	1	1	1	3	3	3	2	4	2	2	2	4	2	3	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:156756531G>A	uc001fqa.2	+	3	938	c.648G>A	c.(646-648)AAG>AAA	p.K216K	PRCC_uc001fqb.2_Silent_p.K216K	NM_005973	NP_005964	Q92733	PRCC_HUMAN	papillary renal cell carcinoma	216					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	kidney(25)|central_nervous_system(2)	27	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTGATACTAAGCCCTCCAGAC	0.562			T	TFE3	papillary renal 								19	74					0	0	0	0	A	156756531	A	A	156756531	2	1	240	1	0	0	0	0	0	0	0	1	12509	962	34	4		4	PRCC	1	156756531	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	853046	156756531	92494090	20	43900											
LY9	4063	broad.mit.edu	37	chr1	160769734	160769734	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcaaaagctacctgggcCgactagacatcaccaagtgg	12	7	11	11	1	2	1	2	0	0	1	2	2	2	1	3	3	2	1	3	3	5	2	rs12049314		TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:160769734C>T	uc001fwu.2	+	2	366	c.316C>T	c.(316-318)CGA>TGA	p.R106*	LY9_uc001fwt.2_Nonsense_Mutation_p.R106*|LY9_uc010pjs.1_Nonsense_Mutation_p.R106*|LY9_uc001fwv.2_Nonsense_Mutation_p.R106*|LY9_uc001fww.2_Nonsense_Mutation_p.R106*|LY9_uc001fwx.2_Nonsense_Mutation_p.R106*|LY9_uc001fwy.1_Nonsense_Mutation_p.R8*	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	106	Extracellular (Potential).|Ig-like V-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTACCTGGGCCGACTAGACAT	0.448													17	87					0	0	0	0	T	160769734	T	T	160769734	4	4	240	1	0	0	0	0	0	1	0	0	9152	644	23	1	322	1	LY9	1	160769734	Nonsense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	4013203	160769734	88480887	21	43901											
LAMC2	3918	broad.mit.edu	37	chr1	183177126	183177126	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacaacactgatggcattCactgcgagaagtgcaagaat	15	8	10	8	1	1	4	1	2	0	2	1	5	1	4	0	1	3	2	0	1	4	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:183177126C>A	uc001gqa.2	+	2	504	c.190C>A	c.(190-192)CAC>AAC	p.H64N	LAMC2_uc001gpz.3_Missense_Mutation_p.H64N|LAMC2_uc010poa.1_5'UTR	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	64	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						TGATGGCATTCACTGCGAGAA	0.483													100	254					4.70724e-39	1.73669e-38	1	0	A	183177126	A	A	183177126	3	1	240	1	0	0	0	0	1	0	0	0	8655	826	29	2	196	2	LAMC2	1	183177126	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	22407392	183177126	66073495	22	43902											
KCNT2	343450	broad.mit.edu	37	chr1	196303052	196303052	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttagaagatcacatgtttgaAtcgatgatgtatctgcaacc	13	13	8	7	1	2	4	1	2	1	2	3	5	2	4	1	0	2	3	1	0	5	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:196303052A>G	uc001gtd.1	-	17	1982	c.1922T>C	c.(1921-1923)ATT>ACT	p.I641T	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.I591T|KCNT2_uc001gtf.1_Missense_Mutation_p.I641T|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.I641T|KCNT2_uc001gth.1_Missense_Mutation_p.I162T	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	641	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						ACATGTTTGAATCGATGATGT	0.403													14	42					0	0	0	0	G	196303052	G	G	196303052	3	3	240	1	0	0	0	0	1	0	0	0	8131	101	4	5	1533	5	KCNT2	1	196303052	Missense_Mutation	SNP	A	TCGA-CV-7252-01A-11D-2012-08	13125926	196303052	52947569	23	43903											
CRB1	23418	broad.mit.edu	37	chr1	197390489	197390489	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggctcagtttgtaacataGccctcaggtttcagactgtt	9	13	10	9	0	3	1	3	0	0	1	3	1	3	1	1	2	2	5	1	2	2	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:197390489G>A	uc001gtz.2	+	6	1666	c.1531G>A	c.(1531-1533)GCC>ACC	p.A511T	CRB1_uc010poz.1_Missense_Mutation_p.A442T|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.A399T|CRB1_uc010ppb.1_Missense_Mutation_p.A511T|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_Missense_Mutation_p.A160T	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	511	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TTGTAACATAGCCCTCAGGTT	0.488													30	61					0	0	0	0	A	197390489	A	A	197390489	3	1	240	1	0	0	0	0	1	0	0	0	3863	971	34	4	1553	4	CRB1	1	197390489	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1087437	197390489	51860132	24	43904											
PTPRC	5788	broad.mit.edu	37	chr1	198713291	198713291	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tacataacatgaagaaaaggGatccacccagtgagccgtct	15	7	9	10	1	1	3	0	2	1	1	2	4	2	4	3	1	3	0	3	1	5	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:198713291G>A	uc001gur.1	+	26	2980	c.2800G>A	c.(2800-2802)GAT>AAT	p.D934N	PTPRC_uc001gus.1_Missense_Mutation_p.D886N|PTPRC_uc001gut.1_Missense_Mutation_p.D773N	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	934	Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GAAGAAAAGGGATCCACCCAG	0.328													6	20					0	0	0	0	A	198713291	A	A	198713291	3	1	240	1	0	0	0	0	1	0	0	0	12862	1174	41	2	2909	2	PTPRC	1	198713291	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1322802	198713291	50537330	25	43905											
GPR25	2848	broad.mit.edu	37	chr1	200842300	200842300	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacgtctacatccccgcgctCtacctggcggccttcgccgt	4	10	9	18	6	2	0	0	0	2	0	4	0	3	0	5	2	3	1	5	2	3	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:200842300C>G	uc001gvn.1	+	1	135	c.135C>G	c.(133-135)CTC>CTG	p.L45L		NM_005298	NP_005289	O00155	GPR25_HUMAN	G protein-coupled receptor 25	45	Helical; Name=1; (Potential).					integral to plasma membrane				ovary(1)	1						TCCCCGCGCTCTACCTGGCGG	0.592													5	18					0	0	0	0	G	200842300	G	G	200842300	2	3	240	1	0	0	0	0	0	0	0	1	6721	900	32	2		2	GPR25	1	200842300	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	2129009	200842300	48408321	26	43906											
KIF21B	23046	broad.mit.edu	37	chr1	200954056	200954056	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgcggtcattgcggggcCgagtgggaggggatgatggg	6	8	21	6	3	1	1	1	1	0	0	1	4	1	3	1	7	2	0	1	7	0	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:200954056C>T	uc001gvs.1	-	27	4051	c.3734G>A	c.(3733-3735)CGG>CAG	p.R1245Q	KIF21B_uc001gvr.1_Missense_Mutation_p.R1245Q|KIF21B_uc009wzl.1_Missense_Mutation_p.R1245Q|KIF21B_uc010ppn.1_Missense_Mutation_p.R1245Q	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1245					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						ATTGCGGGGCCGAGTGGGAGG	0.627													12	48					0	0	0	0	T	200954056	T	T	200954056	3	4	240	1	0	0	0	0	1	0	0	0	8328	652	23	1	1172	1	KIF21B	1	200954056	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	111756	200954056	48296565	27	43907											
GPR37L1	9283	broad.mit.edu	37	chr1	202097163	202097163	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgacctaccagaacgccCgcatgtggtggtactttggc	8	10	12	11	2	0	3	0	2	0	1	0	3	0	3	3	3	3	2	3	3	3	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:202097163C>T	uc001gxj.2	+	2	988	c.925C>T	c.(925-927)CGC>TGC	p.R309C		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	309	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2						CCAGAACGCCCGCATGTGGTG	0.612													25	64					0	0	0	0	T	202097163	T	T	202097163	3	4	240	1	0	0	0	0	1	0	0	0	6730	652	23	1	931	1	GPR37L1	1	202097163	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1143107	202097163	47153458	28	43908											
SLC45A3	85414	broad.mit.edu	37	chr1	205631061	205631061	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgagaaggtgaacccggtGagggcggctgaagctgtcac	9	6	17	9	2	1	4	1	4	0	1	1	5	1	4	1	4	2	3	1	4	3	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:205631061G>A	uc001hda.1	-	4	1491	c.1152C>T	c.(1150-1152)CTC>CTT	p.L384L	SLC45A3_uc010prn.1_Silent_p.L62L|SLC45A3_uc010pro.1_Silent_p.L218L|SLC45A3_uc010prp.1_Intron|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	384	Helical; Name=10; (Potential).				transmembrane transport	integral to membrane			SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			TGAACCCGGTGAGGGCGGCTG	0.622			T	ETV1|ETV5|ELK4|ERG	prostate 								11	48					0	0	0	0	A	205631061	A	A	205631061	2	1	240	1	0	0	0	0	0	0	0	1	14706	1277	45	2		2	SLC45A3	1	205631061	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	3533898	205631061	43619560	29	43909											
OBSCN	84033	broad.mit.edu	37	chr1	228468382	228468382	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccagtgacaagtatgacttCctgcacacggcgggcacgcg	9	6	12	14	4	0	2	0	2	0	0	1	2	1	2	2	2	1	3	2	2	2	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:228468382C>T	uc009xez.1	+	30	8126	c.8082C>T	c.(8080-8082)TTC>TTT	p.F2694F	OBSCN_uc001hsn.2_Silent_p.F2694F|OBSCN_uc001hsp.1_Silent_p.F393F|OBSCN_uc001hsq.1_5'UTR	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2694	Ig-like 26.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGTATGACTTCCTGCACACGG	0.682													28	102					0	0	0	0	T	228468382	T	T	228468382	2	4	240	1	0	0	0	0	0	0	0	1	10866	854	30	2		2	OBSCN	1	228468382	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	22837321	228468382	20782239	30	43910											
KIAA1804	84451	broad.mit.edu	37	chr1	233489592	233489592	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaactgctcaccggagaagtCccctatcggggcattgatgg	9	8	13	11	2	1	2	1	1	0	1	3	4	2	2	3	4	2	2	3	4	3	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:233489592C>T	uc001hvt.3	+	3	1287	c.1026C>T	c.(1024-1026)GTC>GTT	p.V342V	KIAA1804_uc001hvs.1_Silent_p.V342V	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	342	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				CCGGAGAAGTCCCCTATCGGG	0.517													18	57					0	0	0	0	T	233489592	T	T	233489592	2	4	240	1	0	0	0	0	0	0	0	1	8298	842	30	2		2	KIAA1804	1	233489592	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	5021210	233489592	15761029	31	43911											
OR2L2	26246	broad.mit.edu	37	chr1	248201622	248201622	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catcttattggggctgttccCacaatcaagaattggccttt	9	14	8	10	0	2	1	1	0	1	1	3	1	3	1	2	3	0	2	2	3	4	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr1:248201622C>A	uc001idw.2	+	1	149	c.53C>A	c.(52-54)CCA>CAA	p.P18Q	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GGGCTGTTCCCACAATCAAGA	0.368													43	135					1.38162e-09	4.73838e-09	1	0	A	248201622	A	A	248201622	3	1	240	1	0	0	0	0	1	0	0	0	11061	594	21	4	55	4	OR2L2	1	248201622	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	14712030	248201622	1048999	32	43912											
NOL10	79954	broad.mit.edu	37	chr2	10729194	10729194	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtttctgctttgtggcagAatctttgaagcttctaaatt	9	17	8	7	0	3	2	0	1	3	1	3	2	3	2	0	1	2	4	0	1	4	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:10729194A>T	uc002raq.2	-	19	1944	c.1819T>A	c.(1819-1821)TCT>ACT	p.S607T	NOL10_uc010yje.1_Missense_Mutation_p.S581T|NOL10_uc010yjf.1_Missense_Mutation_p.S557T|NOL10_uc002rap.2_Missense_Mutation_p.S557T	NM_024894	NP_079170	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	607						nucleolus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		TTTGTGGCAGAATCTTTGAAG	0.478													65	80					0	0	0	0	T	10729194	T	T	10729194	3	4	240	1	0	0	0	0	1	0	0	0	10574	246	9	5	259	5	NOL10	2	10729194	Missense_Mutation	SNP	A	TCGA-CV-7252-01A-11D-2012-08		10729194	232470179	33	43913											
HADHB	3032	broad.mit.edu	37	chr2	26500001	26500001	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acactgtcaccatggcttgtAtctctgccaaccaagccatg	10	10	7	14	0	2	0	1	0	1	0	3	0	2	0	4	1	3	2	4	1	3	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:26500001A>G	uc002rgz.2	+	7	666	c.415A>G	c.(415-417)ATC>GTC	p.I139V	HADHB_uc010ykv.1_Missense_Mutation_p.I117V|HADHB_uc010ykw.1_Missense_Mutation_p.I124V|HADHB_uc002rha.2_Missense_Mutation_p.I139V|HADHB_uc010ykx.1_Missense_Mutation_p.I65V	NM_000183	NP_000174	P55084	ECHB_HUMAN	mitochondrial trifunctional protein, beta	139					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATGGCTTGTATCTCTGCCAA	0.403													14	19					0	0	0	0	G	26500001	G	G	26500001	3	3	240	1	0	0	0	0	1	0	0	0	6983	449	16	5	437	5	HADHB	2	26500001	Missense_Mutation	SNP	A	TCGA-CV-7252-01A-11D-2012-08	15770807	26500001	216699372	34	43914											
SRD5A2	6716	broad.mit.edu	37	chr2	31805805	31805805	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcgaaggaaggcagctcctGcaggaaccaggcggcgcggg	9	2	18	12	5	0	0	0	0	0	0	1	3	1	2	2	6	3	3	2	6	3	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:31805805G>T	uc002rnw.1	-	2	237	c.166C>A	c.(166-168)CAG>AAG	p.Q56K		NM_000348	NP_000339	P31213	S5A2_HUMAN	3-oxo-5 alpha-steroid 4-dehydrogenase 2	56					androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity				0	Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	GGCAGCTCCTGCAGGAACCAG	0.706													22	13					1.1804e-14	4.13563e-14	1	0	T	31805805	T	T	31805805	3	4	240	1	0	0	0	0	1	0	0	0	15205	1311	46	4	618	4	SRD5A2	2	31805805	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	5305804	31805805	211393568	35	43915											
MAP4K3	8491	broad.mit.edu	37	chr2	39494353	39494353	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacaacacttctggcaccatTtggtttcagggatttttgct	8	15	8	10	0	2	0	1	0	1	0	2	1	2	1	1	3	2	3	1	3	1	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:39494353T>C	uc002rro.2	-	27	2100	c.2009A>G	c.(2008-2010)AAA>AGA	p.K670R	MAP4K3_uc002rrp.2_Missense_Mutation_p.K649R|MAP4K3_uc010yns.1_Missense_Mutation_p.K223R	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	670	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				CTGGCACCATTTGGTTTCAGG	0.313													33	44					0	0	0	0	C	39494353	C	C	39494353	3	2	240	1	0	0	0	0	1	0	0	0	9314	1841	64	5	707	5	MAP4K3	2	39494353	Missense_Mutation	SNP	T	TCGA-CV-7252-01A-11D-2012-08	7688548	39494353	203705020	36	43916											
TET3	200424	broad.mit.edu	37	chr2	74328683	74328683	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctgcccctgggatccagcGagaagctgtttggggctctg	5	10	15	11	1	2	1	0	0	2	1	3	3	3	2	3	3	3	3	3	3	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:74328683G>A	uc002skb.3	+	9	4363	c.4363G>A	c.(4363-4365)GAG>AAG	p.E1455K		NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	1455							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GGGATCCAGCGAGAAGCTGTT	0.652													6	15					0	0	0	0	A	74328683	A	A	74328683	3	1	240	1	0	0	0	0	1	0	0	0	15837	1059	37	1	4397	1	TET3	2	74328683	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	34834330	74328683	168870690	37	43917											
FAM176A	84141	broad.mit.edu	37	chr2	75720729	75720729	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtacagagctgctcgctcaGgattttctggaggaagaaga	12	9	13	7	1	2	3	1	0	1	3	3	6	2	6	0	3	3	4	0	3	3	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:75720729G>A	uc002sni.2	-	4	570	c.92C>T	c.(91-93)CCT>CTT	p.P31L	FAM176A_uc002snj.1_Missense_Mutation_p.P18L|FAM176A_uc002snk.1_Missense_Mutation_p.P31L	NM_001135032	NP_001128504	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	31	Necessary for the localization and biological activity.				apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0						TGCTCGCTCAGGATTTTCTGG	0.517													15	18					0	0	0	0	A	75720729	A	A	75720729	3	1	240	1	0	0	0	0	1	0	0	0	5527	1000	35	4	370	4	FAM176A	2	75720729	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1392046	75720729	167478644	38	43918											
SULT1C3	442038	broad.mit.edu	37	chr2	108881304	108881304	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaaagcgggaaattgagaaGatactgaagttcctggaaaa	17	7	11	6	1	0	3	0	2	0	2	1	6	1	5	2	2	2	1	2	2	7	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:108881304G>C	uc010ywo.1	+	6	645	c.645G>C	c.(643-645)AAG>AAC	p.K215N		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	215	PAPS.					cytoplasm	alcohol sulfotransferase activity			skin(1)	1						AAATTGAGAAGATACTGAAGT	0.398													6	29					0	0	0	0	C	108881304	C	C	108881304	3	2	240	1	0	0	0	0	1	0	0	0	15444	933	33	2	667	2	SULT1C3	2	108881304	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	33160575	108881304	134318069	39	43919											
NPHP1	4867	broad.mit.edu	37	chr2	110962526	110962526	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagggcctggagaggatctCgctgtcgtctcgccagcatc	6	8	14	13	3	2	1	0	0	2	1	6	3	2	2	2	3	1	3	2	3	0	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:110962526C>A	uc002tfn.3	-	1	114	c.20G>T	c.(19-21)CGA>CTA	p.R7L	NPHP1_uc002tfm.3_Missense_Mutation_p.R7L|NPHP1_uc002tfl.3_Missense_Mutation_p.R7L|NPHP1_uc002tfo.3_Missense_Mutation_p.R7L|NPHP1_uc010ywx.1_Missense_Mutation_p.R7L|NPHP1_uc010fjv.1_Missense_Mutation_p.R7L|NPHP1_uc002tfp.2_Missense_Mutation_p.R7L	NM_207181	NP_997064	O15259	NPHP1_HUMAN	nephrocystin 1 isoform 2	7	Potential.				actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			ovary(2)	2						GAGAGGATCTCGCTGTCGTCT	0.662													5	48					2.7689e-08	9.42974e-08	1	0	A	110962526	A	A	110962526	3	1	240	1	0	0	0	0	1	0	0	0	10633	884	31	3	2261	3	NPHP1	2	110962526	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	2081222	110962526	132236847	40	43920											
PLA2R1	22925	broad.mit.edu	37	chr2	160832579	160832579	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgagttatgttcaagtacCgcttttattttgctgtggat	7	18	11	5	1	1	1	1	1	0	0	1	2	1	2	1	2	2	5	1	2	4	7			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:160832579C>T	uc002ube.1	-	17	2802	c.2595G>A	c.(2593-2595)GCG>GCA	p.A865A	PLA2R1_uc010zcp.1_Silent_p.A865A|PLA2R1_uc002ubf.2_Silent_p.A865A	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	865	Extracellular (Potential).|C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GTTCAAGTACCGCTTTTATTT	0.413													26	43					0	0	0	0	T	160832579	T	T	160832579	2	4	240	1	0	0	0	0	0	0	0	1	12065	666	23	1		1	PLA2R1	2	160832579	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	49870053	160832579	82366794	41	43921											
UBR3	130507	broad.mit.edu	37	chr2	170917856	170917856	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tattgcttggtctcctgaatCcatggaaaaatgcttacagg	11	13	9	8	0	1	1	0	1	1	0	3	2	2	2	2	3	3	2	2	3	5	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:170917856C>T	uc010zdi.1	+	35	4922	c.4922C>T	c.(4921-4923)TCC>TTC	p.S1641F	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_Missense_Mutation_p.S462F|UBR3_uc002uft.3_Missense_Mutation_p.S498F|UBR3_uc010zdj.1_Missense_Mutation_p.S332F|UBR3_uc002ufu.3_Missense_Mutation_p.S147F	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1641					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0						TCTCCTGAATCCATGGAAAAA	0.368													45	77					0	0	0	0	T	170917856	T	T	170917856	3	4	240	1	0	0	0	0	1	0	0	0	16971	855	30	2	5060	2	UBR3	2	170917856	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	10085277	170917856	72281517	42	43922											
MYO3B	140469	broad.mit.edu	37	chr2	171243774	171243774	+	Missense_Mutation	SNP	C	G	G																															gttgtgatgggggcaagaatCtctgaatatctcctggaaaa																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:171243774C>G	uc002ufy.2	+	14	1676	c.1533C>G	c.(1531-1533)ATC>ATG	p.I511M	MYO3B_uc002ufv.2_Missense_Mutation_p.I498M|MYO3B_uc010fqb.1_Missense_Mutation_p.I498M|MYO3B_uc002ufz.2_Missense_Mutation_p.I511M|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	511	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GGGCAAGAATCTCTGAATATC	0.428													23	64					0	0	0	0	G	171243774	G	G	171243774	3	3	240	1	0	0	0	0	1	0	0	0	10130	903	32	2	1587	2	MYO3B	2	171243774	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	325918	171243774	71955599	43	43923	91	2									
MYO3B	140469	broad.mit.edu	37	chr2	171243784	171243784	+	Missense_Mutation	SNP	C	G	G																															gggcaagaatctctgaatatCtcctggaaaaatccagagtt																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:171243784C>G	uc002ufy.2	+	14	1686	c.1543C>G	c.(1543-1545)CTC>GTC	p.L515V	MYO3B_uc002ufv.2_Missense_Mutation_p.L502V|MYO3B_uc010fqb.1_Missense_Mutation_p.L502V|MYO3B_uc002ufz.2_Missense_Mutation_p.L515V|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	515	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						CTCTGAATATCTCCTGGAAAA	0.413													24	57					0	0	0	0	G	171243784	G	G	171243784	3	3	240	1	0	0	0	0	1	0	0	0	10130	913	32	2	1597	2	MYO3B	2	171243784	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	10	171243784	71955589	44	43924	91	2									
CASP8	841	broad.mit.edu	37	chr2	202149546	202149551	+	In_Frame_Del	DEL	GACCAC	-	-																															tttcacttttcaggggctttGaccacgacctttgaagagct																								rs139337151		TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:202149546_202149551delGACCAC	uc002uxr.1	+	9	1019_1024	c.810_815delGACCAC	c.(808-816)TTGACCACG>TTG	p.TT271del	CASP8_uc002uxp.1_In_Frame_Del_p.TT288del|CASP8_uc002uxq.1_In_Frame_Del_p.TT256del|CASP8_uc002uxt.1_In_Frame_Del_p.TT330del|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_In_Frame_Del_p.TT256del|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_In_Frame_Del_p.TT187del	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	271_272					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CAGGGGCTTTGACCACGACCTTTGAA	0.422										HNSCC(4;0.00038)			---	---	---								-	202149551	-	-	202149546	7	5	240	1	0	1	0	1	0	0	0	0	2689	1281	45	0	1117	0	CASP8	2	202149546	In_Frame_Del	DEL	GACCAC	TCGA-CV-7252-01A-11D-2012-08	30905762	202149546	41049827	45	43925											
MAP2	4133	broad.mit.edu	37	chr2	210543343	210543343	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagtcactgctgaggctgtaGcagtcctgaaaggtgaacaa	12	9	12	8	0	1	3	1	3	0	0	2	3	2	3	1	2	3	4	1	2	5	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:210543343G>T	uc002vde.1	+	5	558	c.310G>T	c.(310-312)GCA>TCA	p.A104S	MAP2_uc002vdc.1_Missense_Mutation_p.A104S|MAP2_uc002vdd.1_Missense_Mutation_p.A104S|MAP2_uc002vdf.1_Missense_Mutation_p.A104S|MAP2_uc002vdg.1_Missense_Mutation_p.A104S|MAP2_uc002vdh.1_Missense_Mutation_p.A104S|MAP2_uc002vdi.1_Missense_Mutation_p.A104S	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	104					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TGAGGCTGTAGCAGTCCTGAA	0.413													30	44					3.1745e-13	1.10823e-12	1	0	T	210543343	T	T	210543343	3	4	240	1	0	0	0	0	1	0	0	0	9288	971	34	4	316	4	MAP2	2	210543343	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	8393797	210543343	32656030	46	43926											
DGKD	8527	broad.mit.edu	37	chr2	234354353	234354353	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcctgcgatgacgacaccCagctcccccagatcttggag	9	6	10	16	2	1	2	0	1	1	1	2	5	2	3	4	1	3	1	4	1	0	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:234354353C>T	uc002vui.1	+	11	1291	c.1279C>T	c.(1279-1281)CAG>TAG	p.Q427*	DGKD_uc002vuj.1_Nonsense_Mutation_p.Q383*|DGKD_uc010fyh.1_Nonsense_Mutation_p.Q294*|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	427	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	TGACGACACCCAGCTCCCCCA	0.607													28	40					0	0	0	0	T	234354353	T	T	234354353	4	4	240	1	0	0	0	0	0	1	0	0	4489	595	21	4	1345	4	DGKD	2	234354353	Nonsense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	23811010	234354353	8845020	47	43927											
HDAC4	9759	broad.mit.edu	37	chr2	240036972	240036972	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctcctccgggtggctctccGgctgccgggctggctcgctt	0	11	14	16	4	2	0	0	0	2	0	6	0	3	0	4	5	1	5	4	5	0	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr2:240036972G>A	uc002vyk.3	-	13	2345	c.1553C>T	c.(1552-1554)CCG>CTG	p.P518L	HDAC4_uc010fyz.1_Missense_Mutation_p.P513L|HDAC4_uc010zoa.1_Missense_Mutation_p.P518L|HDAC4_uc010fza.2_Missense_Mutation_p.P523L|HDAC4_uc010fyy.2_Missense_Mutation_p.P475L|HDAC4_uc010znz.1_Missense_Mutation_p.P401L	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	518					B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GTGGCTCTCCGGCTGCCGGGC	0.652													31	53					0	0	0	0	A	240036972	A	A	240036972	3	1	240	1	0	0	0	0	1	0	0	0	7048	1116	39	1	1761	1	HDAC4	2	240036972	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	5682619	240036972	3162401	48	43928											
TGFBR2	7048	broad.mit.edu	37	chr3	30713559	30713559	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacagagaaggacatcttctCagacatcaatctgaagcatg	15	8	9	9	0	4	3	2	1	3	2	5	6	4	4	0	1	1	1	0	1	3	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr3:30713559C>G	uc003ceo.2	+	4	1266	c.884C>G	c.(883-885)TCA>TGA	p.S295*	TGFBR2_uc003cen.2_Nonsense_Mutation_p.S320*	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	295	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						GACATCTTCTCAGACATCAAT	0.493													24	55					0	0	0	0	G	30713559	G	G	30713559	4	3	240	1	0	0	0	0	0	1	0	0	15888	838	29	2	977	2	TGFBR2	3	30713559	Nonsense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08		30713559	167308871	49	43929											
IGSF10	285313	broad.mit.edu	37	chr3	151154847	151154847	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttacagatatagtttcctCtgtcataagctgttgcttct	8	17	6	10	0	3	1	1	0	2	1	4	1	4	1	2	0	3	4	2	0	4	7			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr3:151154847C>G	uc011bod.1	-	6	7502	c.7502G>C	c.(7501-7503)AGA>ACA	p.R2501T	IGSF10_uc011bob.1_Missense_Mutation_p.R528T|IGSF10_uc011boc.1_Missense_Mutation_p.R480T	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2501	Ig-like C2-type 11.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATAGTTTCCTCTGTCATAAGC	0.393													40	142					0	0	0	0	G	151154847	G	G	151154847	3	3	240	1	0	0	0	0	1	0	0	0	7636	913	32	2	373	2	IGSF10	3	151154847	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	120441288	151154847	46867583	50	43930											
SMC4	10051	broad.mit.edu	37	chr3	160135570	160135570	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatgaagcacgttcaaagatGgatgtagcccagtcagaact	15	8	10	8	1	2	3	2	1	0	2	2	4	2	4	1	1	3	3	1	1	5	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr3:160135570G>A	uc003fdh.2	+	11	1610	c.1497G>A	c.(1495-1497)ATG>ATA	p.M499I	IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Missense_Mutation_p.M263I|SMC4_uc003fdi.2_Missense_Mutation_p.M474I|SMC4_uc003fdj.2_Missense_Mutation_p.M499I|SMC4_uc010hwd.2_Missense_Mutation_p.M499I|SMC4_uc003fdl.2_Missense_Mutation_p.M202I	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	499	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GTTCAAAGATGGATGTAGCCC	0.378													19	79					0	0	0	0	A	160135570	A	A	160135570	3	1	240	1	0	0	0	0	1	0	0	0	14849	1348	47	4	1535	4	SMC4	3	160135570	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	8980723	160135570	37886860	51	43931											
TLR6	10333	broad.mit.edu	37	chr4	38828928	38828928	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attagatccttcatgaaagaGattgtgatgggcaaaataga	16	11	10	4	0	1	5	1	2	0	3	2	6	2	5	1	1	0	1	1	1	5	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr4:38828928G>C	uc003gtm.2	-	1	2233	c.2167C>G	c.(2167-2169)CTC>GTC	p.L723V	TLR6_uc010ifg.1_Missense_Mutation_p.L723V	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	723	TIR.|Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						TCATGAAAGAGATTGTGATGG	0.423													54	132					0	0	0	0	C	38828928	C	C	38828928	3	2	240	1	0	0	0	0	1	0	0	0	16021	942	33	2	227	2	TLR6	4	38828928	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08		38828928	152325348	52	43932											
GABRA4	2557	broad.mit.edu	37	chr4	46930480	46930480	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcttgatccaaacacgtgaCgagtagaagcagatccaact	14	8	9	10	2	1	4	0	2	1	2	3	5	3	4	2	0	3	2	2	0	4	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr4:46930480C>T	uc003gxg.2	-	9	1566	c.1427G>A	c.(1426-1428)CGT>CAT	p.R476H		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	476	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAACACGTGACGAGTAGAAGC	0.483													25	84					0	0	0	0	T	46930480	T	T	46930480	3	4	240	1	0	0	0	0	1	0	0	0	6197	536	19	1	241	1	GABRA4	4	46930480	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	8101552	46930480	144223796	53	43933											
CEP135	9662	broad.mit.edu	37	chr4	56820513	56820513	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaaagaattcaacaacttCaagaaaagaatttgcatgct	19	10	6	6	0	2	4	2	1	0	3	2	4	2	4	0	0	4	2	0	0	8	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr4:56820513C>G	uc003hbi.2	+	4	670	c.436C>G	c.(436-438)CAA>GAA	p.Q146E	CEP135_uc003hbh.1_Missense_Mutation_p.Q146E|CEP135_uc010igz.1_5'UTR	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	146	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					TCAACAACTTCAAGAAAAGAA	0.323													21	48					0	0	0	0	G	56820513	G	G	56820513	3	3	240	1	0	0	0	0	1	0	0	0	3262	827	29	2	446	2	CEP135	4	56820513	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	9890033	56820513	134333763	54	43934											
LRIT3	345193	broad.mit.edu	37	chr4	110790844	110790844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagtcagatggtccataatGagcttgacaggcatttcttc	10	12	11	8	0	2	3	1	2	1	1	4	4	3	4	1	3	1	2	1	3	1	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr4:110790844G>A	uc003hzx.3	+	3	997	c.804G>A	c.(802-804)ATG>ATA	p.M268I	LRIT3_uc003hzw.3_Missense_Mutation_p.M130I	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	268	Ig-like.					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		GGTCCATAATGAGCTTGACAG	0.423													23	116					0	0	0	0	A	110790844	A	A	110790844	3	1	240	1	0	0	0	0	1	0	0	0	8999	1290	45	2	814	2	LRIT3	4	110790844	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	53970331	110790844	80363432	55	43935											
FAT1	2195	broad.mit.edu	37	chr4	187534466	187534467	+	Frame_Shift_Ins	INS	-	G	G																															ataaacagcttgctcctcacINSgatcaaggggggttgacgtt																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr4:187534466_187534467insG	uc003izf.2	-	13	9447_9448	c.9259_9260insC	c.(9259-9261)CGTfs	p.R3087fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3087	Extracellular (Potential).|Cadherin 28.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTGCTCCTCACGATCAAGGGGG	0.446										HNSCC(5;0.00058)			---	---	---								G	187534467	G	G	187534466	7	5	240	1	0	1	1	0	0	0	0	0	5721	536	19	0	4566	0	FAT1	4	187534466	Frame_Shift_Ins	INS	-	TCGA-CV-7252-01A-11D-2012-08	76743622	187534466	3619810	56	43936											
FAT1	2195	broad.mit.edu	37	chr4	187539457	187539469	+	Frame_Shift_Del	DEL	CTTCAGTCTCCCG	-	-																															tgatcaagactcttctccaaCttcagtctcccgctctgtct																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr4:187539457_187539469delCTTCAGTCTCCCG	uc003izf.2	-	10	8459_8471	c.8271_8283delCGGGAGACTGAAG	c.(8269-8283)AGCGGGAGACTGAAGfs	p.S2757fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2757_2761	Extracellular (Potential).|Cadherin 25.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TCTTCTCCAACTTCAGTCTCCCGCTCTGTCTGT	0.465										HNSCC(5;0.00058)			---	---	---								-	187539469	-	-	187539457	7	5	240	1	0	1	0	1	0	0	0	0	5721	564	20	0	5555	0	FAT1	4	187539457	Frame_Shift_Del	DEL	CTTCAGTCTCCCG	TCGA-CV-7252-01A-11D-2012-08	4991	187539457	3614819	57	43937											
TRIML1	339976	broad.mit.edu	37	chr4	189068147	189068147	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccagtgggagacactactGggaggtggaggtgggaaaca	12	5	17	7	0	0	1	0	0	0	1	0	5	0	4	1	6	2	0	1	6	2	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr4:189068147G>T	uc003izm.1	+	6	1143	c.1028G>T	c.(1027-1029)TGG>TTG	p.W343L	TRIML1_uc003izn.1_Missense_Mutation_p.W67L	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	343	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AGACACTACTGGGAGGTGGAG	0.567													14	85					0.000151284	0.000492813	1	0	T	189068147	T	T	189068147	3	4	240	1	0	0	0	0	1	0	0	0	16617	1357	47	4	1050	4	TRIML1	4	189068147	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1528690	189068147	2086129	58	43938											
PDZD2	23037	broad.mit.edu	37	chr5	32088220	32088220	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catccatgtatggcgatgctGaggattcttcttctgaccct	7	14	9	11	1	3	2	0	2	3	0	4	4	4	3	2	2	1	2	2	2	1	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:32088220G>A	uc003jhl.2	+	20	5054	c.4666G>A	c.(4666-4668)GAG>AAG	p.E1556K	PDZD2_uc003jhm.2_Missense_Mutation_p.E1556K	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1556					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						TGGCGATGCTGAGGATTCTTC	0.542													28	64					0	0	0	0	A	32088220	A	A	32088220	3	1	240	1	0	0	0	0	1	0	0	0	11755	1291	45	2	4740	2	PDZD2	5	32088220	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08		32088220	148827040	59	43939											
OSMR	9180	broad.mit.edu	37	chr5	38933124	38933124	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaagcctaactacctttatCtccttccaacagaaaagaat	15	11	3	12	0	1	2	0	0	1	2	3	2	2	2	4	0	4	0	4	0	8	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:38933124C>T	uc003jln.1	+	18	2885	c.2518C>T	c.(2518-2520)CTC>TTC	p.L840F	OSMR_uc011cpj.1_Missense_Mutation_p.L44F	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	840	Cytoplasmic (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					CTACCTTTATCTCCTTCCAAC	0.468													37	137					0	0	0	0	T	38933124	T	T	38933124	3	4	240	1	0	0	0	0	1	0	0	0	11346	913	32	2	2622	2	OSMR	5	38933124	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	6844904	38933124	141982136	60	43940											
PDE8B	8622	broad.mit.edu	37	chr5	76645309	76645309	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagctcctgggaaaagaactCgctgatctgcccaaaagcga	13	6	11	11	2	1	2	0	1	1	1	3	5	2	3	2	1	4	2	2	1	5	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:76645309C>T	uc003kfa.2	+	8	987	c.942C>T	c.(940-942)CTC>CTT	p.L314L	PDE8B_uc003kfb.2_Silent_p.L294L|PDE8B_uc003kfc.2_Silent_p.L314L|PDE8B_uc003kfd.2_Intron|PDE8B_uc003kfe.2_Intron	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	314	PAS.				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GAAAAGAACTCGCTGATCTGC	0.502													22	68					0	0	0	0	T	76645309	T	T	76645309	2	4	240	1	0	0	0	0	0	0	0	1	11708	871	31	1		1	PDE8B	5	76645309	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	37712185	76645309	104269951	61	43941											
IRF1	3659	broad.mit.edu	37	chr5	131819732	131819732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcatccatgttcttcagatCtgtgaagacacgctgtagac	10	11	10	10	1	3	4	1	1	2	3	4	4	4	4	1	1	0	4	1	1	2	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:131819732C>T	uc003kxa.2	-	10	1123	c.889G>A	c.(889-891)GAT>AAT	p.D297N	C5orf56_uc010jds.1_Intron|IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Missense_Mutation_p.D297N	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	297					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		TTCTTCAGATCTGTGAAGACA	0.582													18	77					0	0	0	0	T	131819732	T	T	131819732	3	4	240	1	0	0	0	0	1	0	0	0	7866	913	32	2	92	2	IRF1	5	131819732	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	55174423	131819732	49095528	62	43942			1	66		4	3	422	N	C	6.659484e-06
IRF1	3659	broad.mit.edu	37	chr5	131820066	131820066	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcttaccccctgggctgtCaatttctggctcctccttac	4	15	6	16	0	3	0	1	0	2	0	5	0	5	0	4	2	2	2	4	2	3	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:131820066C>G	uc003kxa.2	-	9	1075	c.841G>C	c.(841-843)GAC>CAC	p.D281H	C5orf56_uc010jds.1_Intron|IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Missense_Mutation_p.D281H	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	281					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		CCTGGGCTGTCAATTTCTGGC	0.552													19	99					0	0	0	0	G	131820066	G	G	131820066	3	3	240	1	0	0	0	0	1	0	0	0	7866	826	29	2	144	2	IRF1	5	131820066	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	334	131820066	49095194	63	43943			1	66		4	3	422	N	C	6.659484e-06
IRF1	3659	broad.mit.edu	37	chr5	131820143	131820143	+	Missense_Mutation	SNP	C	T	T																															caggttcattgagtaggtacCccttcccatccacgtttgtt																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:131820143C>T	uc003kxa.2	-	9	998	c.764G>A	c.(763-765)GGG>GAG	p.G255E	C5orf56_uc010jds.1_Intron|IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Missense_Mutation_p.G255E	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	255					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		GAGTAGGTACCCCTTCCCATC	0.552													22	141					0	0	0	0	T	131820143	T	T	131820143	3	4	240	1	0	0	0	0	1	0	0	0	7866	623	22	4	221	4	IRF1	5	131820143	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	77	131820143	49095117	64	43944	92	2	1	66		4	3	422	N	C	6.659484e-06
IRF1	3659	broad.mit.edu	37	chr5	131820153	131820153	+	Missense_Mutation	SNP	C	T	T																															gagtaggtaccccttcccatCcacgtttgttggctgccact																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:131820153C>T	uc003kxa.2	-	9	988	c.754G>A	c.(754-756)GAT>AAT	p.D252N	C5orf56_uc010jds.1_Intron|IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Missense_Mutation_p.D252N	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	252					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		CCCTTCCCATCCACGTTTGTT	0.567													23	146					0	0	0	0	T	131820153	T	T	131820153	3	4	240	1	0	0	0	0	1	0	0	0	7866	855	30	2	231	2	IRF1	5	131820153	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	10	131820153	49095107	65	43945	92	2	1	66		4	3	422	N	C	6.659484e-06
PCDH12	51294	broad.mit.edu	37	chr5	141335106	141335106	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggtggatgtctgccttctGaatgtgtttctggggcctct	4	15	14	8	0	4	1	0	1	4	0	4	3	4	2	2	4	1	1	2	4	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:141335106G>A	uc003llx.2	-	1	3522	c.2311C>T	c.(2311-2313)CAG>TAG	p.Q771*		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	771	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGCCTTCTGAATGTGTTTC	0.587													11	62					0	0	0	0	A	141335106	A	A	141335106	4	1	240	1	0	0	0	0	0	1	0	0	11564	1299	45	2	1259	2	PCDH12	5	141335106	Nonsense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	9514953	141335106	39580154	66	43946											
C5orf4	10826	broad.mit.edu	37	chr5	154214195	154214195	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaacctcacctataaagaaGaggatccactccttcccttc	12	9	6	14	0	1	2	1	0	0	2	5	4	4	4	5	2	1	0	5	2	5	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:154214195G>A	uc003lvs.3	-	4	405	c.234C>T	c.(232-234)CTC>CTT	p.L78L	C5orf4_uc011dde.1_Silent_p.L55L	NM_032385	NP_115761	Q96IV6	CE004_HUMAN	hypothetical protein LOC10826	78	Helical; (Potential).				fatty acid biosynthetic process	integral to membrane	iron ion binding|oxidoreductase activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CTATAAAGAAGAGGATCCACT	0.453													13	40					0	0	0	0	A	154214195	A	A	154214195	2	1	240	1	0	0	0	0	0	0	0	1	2308	929	33	2		2	C5orf4	5	154214195	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	12879089	154214195	26701065	67	43947											
KCNMB1	3779	broad.mit.edu	37	chr5	169805750	169805750	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaggtactggttgctcttCaccatggcgataatgaggag	10	10	13	8	1	2	1	1	1	1	0	2	4	2	2	1	4	2	3	1	4	2	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:169805750C>T	uc003maq.1	-	4	934	c.534G>A	c.(532-534)GTG>GTA	p.V178V	KCNIP1_uc003map.2_Intron	NM_004137	NP_004128	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated	178	Helical; Name=2; (Potential).				platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			ovary(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		GGTTGCTCTTCACCATGGCGA	0.627													21	82					0	0	0	0	T	169805750	T	T	169805750	2	4	240	1	0	0	0	0	0	0	0	1	8113	813	29	2		2	KCNMB1	5	169805750	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	15591555	169805750	11109510	68	43948											
UNC5A	90249	broad.mit.edu	37	chr5	176306459	176306459	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taggcggggtgccgactggcGgactctggcccagaaactcc	7	6	15	13	3	1	1	0	0	1	1	2	3	2	2	3	6	2	0	3	6	2	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:176306459G>A	uc003mey.2	+	14	2525	c.2333G>A	c.(2332-2334)CGG>CAG	p.R778Q		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	778	Death.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCGACTGGCGGACTCTGGCC	0.677													28	118					0	0	0	0	A	176306459	A	A	176306459	3	1	240	1	0	0	0	0	1	0	0	0	17059	1116	39	1	2387	1	UNC5A	5	176306459	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	6500709	176306459	4608801	69	43949											
MXD3	83463	broad.mit.edu	37	chr5	176734658	176734658	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgaagccccgcagcagctcGgcctcacccccaaacaccag	11	2	8	20	3	1	0	1	0	0	0	2	1	1	0	6	1	4	3	6	1	2	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr5:176734658G>A	uc003mgb.2	-	6	1013	c.552C>T	c.(550-552)GCC>GCT	p.A184A	MXD3_uc010jkk.2_Intron|MXD3_uc003mga.3_Missense_Mutation_p.P210L|MXD3_uc003mgc.2_Silent_p.A174A	NM_031300	NP_112590	Q9BW11	MAD3_HUMAN	MAX dimerization protein 3 isoform a	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCAGCAGCTCGGCCTCACCCC	0.701													18	59					0	0	0	0	A	176734658	A	A	176734658	2	1	240	1	0	0	0	0	0	0	0	1	10053	1103	39	1		1	MXD3	5	176734658	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	428199	176734658	4180602	70	43950											
BTN2A2	10385	broad.mit.edu	37	chr6	26388333	26388333	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggtggtacccagagcccCtcacagtgtggagggacccc	8	5	15	13	0	1	1	1	0	0	1	1	4	1	3	5	4	2	1	5	4	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:26388333C>T	uc003nhq.2	+	4	621	c.535C>T	c.(535-537)CTC>TTC	p.L179F	BTN2A2_uc011dkf.1_Missense_Mutation_p.L63F|BTN2A2_uc011dkg.1_Intron|BTN2A2_uc003nhr.2_Missense_Mutation_p.L63F|BTN2A2_uc011dkh.1_Intron|BTN2A2_uc003nhs.2_Missense_Mutation_p.L179F|BTN2A2_uc003nht.2_Missense_Mutation_p.L179F|BTN2A2_uc011dki.1_5'Flank	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	179	Extracellular (Potential).|Ig-like C2-type.				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						CCCAGAGCCCCTCACAGTGTG	0.582													16	60					0	0	0	0	T	26388333	T	T	26388333	3	4	240	1	0	0	0	0	1	0	0	0	1566	681	24	4	545	4	BTN2A2	6	26388333	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08		26388333	144726734	71	43951											
ZNF391	346157	broad.mit.edu	37	chr6	27368900	27368900	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggagagaatccctatgaaTgcagtaaatgtggaaaagct	15	9	11	6	0	0	2	0	1	0	1	1	5	1	4	1	2	2	3	1	2	7	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:27368900T>C	uc003njf.1	+	3	1269	c.751T>C	c.(751-753)TGC>CGC	p.C251R		NM_001076781	NP_001070249	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	251	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(2)|skin(1)	3						TCCCTATGAATGCAGTAAATG	0.438													4	30					0	0	0	0	C	27368900	C	C	27368900	3	2	240	1	0	0	0	0	1	0	0	0	17946	1464	51	5	753	5	ZNF391	6	27368900	Missense_Mutation	SNP	T	TCGA-CV-7252-01A-11D-2012-08	980567	27368900	143746167	72	43952											
SCAND3	114821	broad.mit.edu	37	chr6	28540086	28540086	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcgtggatcttcttttgatgGaaaataaaattcaaaacatt	15	14	7	5	1	3	1	1	1	2	0	3	3	3	3	0	2	1	0	0	2	6	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:28540086G>A	uc003nlo.2	-	4	4198	c.3580C>T	c.(3580-3582)CCA>TCA	p.P1194S		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1194					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						tcttttgatggaaaataaaat	0													4	20					0	0	0	0	A	28540086	A	A	28540086	3	1	240	1	0	0	0	0	1	0	0	0	13941	1174	41	2	401	2	SCAND3	6	28540086	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1171186	28540086	142574981	73	43953											
RXRB	6257	broad.mit.edu	37	chr6	33164363	33164363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccatccttgtcctttccccGctgacgctcctcctgtaccg	3	12	6	20	3	0	1	0	1	0	0	5	1	5	1	8	0	1	3	8	0	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:33164363G>A	uc003odb.2	-	5	1020	c.841C>T	c.(841-843)CGG>TGG	p.R281W	RXRB_uc003odc.2_Missense_Mutation_p.R281W|RXRB_uc003odd.2_Missense_Mutation_p.R185W|RXRB_uc011dqr.1_Missense_Mutation_p.R91W|RXRB_uc011dqs.1_Missense_Mutation_p.R164W|RXRB_uc003ode.1_Missense_Mutation_p.R145W|RXRB_uc011dqt.1_Missense_Mutation_p.R281W|RXRB_uc011dqu.1_Missense_Mutation_p.R185W	NM_021976	NP_068811	P28702	RXRB_HUMAN	retinoid X receptor, beta	281	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			ovary(3)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Bexarotene(DB00307)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TCCTTTCCCCGCTGACGCTCC	0.602													11	67					0	0	0	0	A	33164363	A	A	33164363	3	1	240	1	0	0	0	0	1	0	0	0	13829	1086	38	1	784	1	RXRB	6	33164363	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	4624277	33164363	137950704	74	43954											
PACSIN1	29993	broad.mit.edu	37	chr6	34496436	34496436	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcccacagtatggcagcCtggagcgggcctggggtgcc	6	5	17	13	1	0	0	0	0	0	0	0	1	0	1	4	6	3	2	4	6	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:34496436C>T	uc003ojo.2	+	4	444	c.238C>T	c.(238-240)CTG>TTG	p.L80L	PACSIN1_uc003ojp.2_Silent_p.L80L	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	80					endocytosis		protein kinase activity				0						GTATGGCAGCCTGGAGCGGGC	0.527													37	131					0	0	0	0	T	34496436	T	T	34496436	2	4	240	1	0	0	0	0	0	0	0	1	11428	680	24	4		4	PACSIN1	6	34496436	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1332073	34496436	136618631	75	43955											
SPDEF	25803	broad.mit.edu	37	chr6	34507170	34507170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccagctctcctcactggtcGaggctgggtggccagggagg	5	8	16	12	1	2	0	1	0	1	0	5	2	3	1	3	6	1	2	3	6	0	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:34507170G>A	uc003ojq.1	-	5	1101	c.686C>T	c.(685-687)TCG>TTG	p.S229L	SPDEF_uc011dsq.1_Missense_Mutation_p.S213L	NM_012391	NP_036523	O95238	SPDEF_HUMAN	SAM pointed domain containing ets transcription	229					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S229L(1)		skin(3)|ovary(1)|central_nervous_system(1)	5						CTCACTGGTCGAGGCTGGGTG	0.667													22	109					0	0	0	0	A	34507170	A	A	34507170	3	1	240	1	0	0	0	0	1	0	0	0	15092	1059	37	1	329	1	SPDEF	6	34507170	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	10734	34507170	136607897	76	43956											
ENPP4	22875	broad.mit.edu	37	chr6	46108043	46108043	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acaagtgatcatgggatgacCcagtgttctcaggacagact	12	9	11	9	0	2	3	2	2	1	1	3	5	2	5	1	2	0	1	1	2	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:46108043C>T	uc003oxy.2	+	2	982	c.723C>T	c.(721-723)ACC>ACT	p.T241T		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	241	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						ATGGGATGACCCAGTGTTCTC	0.393													18	62					0	0	0	0	T	46108043	T	T	46108043	2	4	240	1	0	0	0	0	0	0	0	1	5156	610	22	4		4	ENPP4	6	46108043	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	11600873	46108043	125007024	77	43957											
PKHD1	5314	broad.mit.edu	37	chr6	51921548	51921548	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaccaaaggggttccagtttGcattttactgcaagtaactc	11	12	9	9	0	0	0	0	0	0	0	2	1	1	0	2	2	4	5	2	2	4	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:51921548G>A	uc003pah.1	-	18	1917	c.1641C>T	c.(1639-1641)TGC>TGT	p.C547C	PKHD1_uc003pai.2_Silent_p.C547C	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	547	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GTTCCAGTTTGCATTTTACTG	0.413													24	82					0	0	0	0	A	51921548	A	A	51921548	2	1	240	1	0	0	0	0	0	0	0	1	12026	1311	46	4		4	PKHD1	6	51921548	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	5813505	51921548	119193519	78	43958											
EFHC1	114327	broad.mit.edu	37	chr6	52317592	52317592	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgtaagtatgtcaccccatCagactttgatcaactcaagc	12	11	6	12	1	4	2	4	1	0	1	5	2	4	2	2	0	2	2	2	0	4	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:52317592C>T	uc003pap.3	+	4	895	c.680C>T	c.(679-681)TCA>TTA	p.S227L	EFHC1_uc011dwv.1_Missense_Mutation_p.S136L|EFHC1_uc011dww.1_Missense_Mutation_p.S208L	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	227						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					GTCACCCCATCAGACTTTGAT	0.398													22	88					0	0	0	0	T	52317592	T	T	52317592	3	4	240	1	0	0	0	0	1	0	0	0	4968	838	29	2	704	2	EFHC1	6	52317592	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	396044	52317592	118797475	79	43959											
BACH2	60468	broad.mit.edu	37	chr6	90660231	90660231	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagggtgagcccccgctccCgtcctccgcgtaggaatagg	6	6	14	15	4	0	1	0	1	0	0	3	2	3	2	5	3	1	3	5	3	3	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:90660231C>G	uc011eab.1	-	7	2403	c.1594G>C	c.(1594-1596)GGG>CGG	p.G532R	BACH2_uc003pnw.2_Missense_Mutation_p.G532R|BACH2_uc010kch.2_Missense_Mutation_p.G532R	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	532						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		CCCCCGCTCCCGTCCTCCGCG	0.622													17	51					0	0	0	0	G	90660231	G	G	90660231	3	3	240	1	0	0	0	0	1	0	0	0	1286	652	23	3	943	3	BACH2	6	90660231	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	38342639	90660231	80454836	80	43960											
C6orf186	728464	broad.mit.edu	37	chr6	110567452	110567452	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcactttccagatctgccttGagaacgtcaatctgtaacaa	12	11	7	11	1	3	2	1	1	2	2	4	3	4	2	2	0	3	2	2	0	4	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:110567452G>A	uc010kdu.1	-	5	798	c.798C>T	c.(796-798)CTC>CTT	p.L266L	C6orf186_uc003pub.2_Silent_p.L69L	NM_001123364	NP_001116836	Q5JXM2	CF186_HUMAN	chromosome 6 open reading frame 186 precursor	266						extracellular region					0						GATCTGCCTTGAGAACGTCAA	0.373													10	28					0	0	0	0	A	110567452	A	A	110567452	2	1	240	1	0	0	0	0	0	0	0	1	2357	1277	45	2		2	C6orf186	6	110567452	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	19907221	110567452	60547615	81	43961											
REV3L	5980	broad.mit.edu	37	chr6	111693797	111693797	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagggaaaaaataactgattAcctgggcttttctggtacat	14	12	9	6	0	1	1	0	1	1	0	1	2	1	2	1	3	3	2	1	3	7	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:111693797A>G	uc003puy.3	-	13	6082	c.5759_splice	c.e13+1	p.R1920_splice	REV3L_uc003pux.3_Splice_Site_p.R1842_splice|REV3L_uc003puz.3_Splice_Site_p.R1842_splice	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta						DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		ATAACTGATTACCTGGGCTTT	0.348								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					18	67					0	0	0	0	G	111693797	G	G	111693797	5	3	240	1	0	0	0	0	0	0	1	0	13305	405	14	5	3711	5	REV3L	6	111693797	Splice_Site	SNP	A	TCGA-CV-7252-01A-11D-2012-08	1126345	111693797	59421270	82	43962											
LAMA4	3910	broad.mit.edu	37	chr6	112506519	112506519	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttgtatctttcttagggCgtattggttttctctttctg	4	22	9	6	1	4	0	0	0	4	0	5	1	4	0	0	2	0	3	0	2	3	9			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:112506519C>T	uc003pvu.2	-	9	1306	c.997G>A	c.(997-999)GCC>ACC	p.A333T	LAMA4_uc003pvv.2_Missense_Mutation_p.A326T|LAMA4_uc003pvt.2_Missense_Mutation_p.A326T	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	333	Potential.|Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTTCTTAGGGCGTATTGGTTT	0.358													26	111					0	0	0	0	T	112506519	T	T	112506519	3	4	240	1	0	0	0	0	1	0	0	0	8648	768	27	1	4598	1	LAMA4	6	112506519	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	812722	112506519	58608548	83	43963											
LAMA4	3910	broad.mit.edu	37	chr6	112508752	112508752	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttgccttcctcgatggagAgcgctgctaaccgcagtgca	8	10	11	12	3	0	1	0	0	0	1	2	3	1	1	3	1	5	4	3	1	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:112508752A>G	uc003pvu.2	-	8	1175	c.866T>C	c.(865-867)CTC>CCC	p.L289P	LAMA4_uc003pvv.2_Missense_Mutation_p.L282P|LAMA4_uc003pvt.2_Missense_Mutation_p.L282P	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	289	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CTCGATGGAGAGCGCTGCTAA	0.527													10	33					0	0	0	0	G	112508752	G	G	112508752	3	3	240	1	0	0	0	0	1	0	0	0	8648	304	11	5	4733	5	LAMA4	6	112508752	Missense_Mutation	SNP	A	TCGA-CV-7252-01A-11D-2012-08	2233	112508752	58606315	84	43964											
RSPH4A	345895	broad.mit.edu	37	chr6	116938138	116938138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acaggaccacgagtgtgattCctgaagctgggacaccttat	11	9	11	10	1	0	2	0	2	0	0	1	5	1	4	3	2	1	1	3	2	2	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:116938138C>T	uc003pxe.2	+	1	497	c.352C>T	c.(352-354)CCT>TCT	p.P118S	RSPH4A_uc010kee.2_Missense_Mutation_p.P118S	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	118					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						GAGTGTGATTCCTGAAGCTGG	0.537									Kartagener_syndrome				23	78					0	0	0	0	T	116938138	T	T	116938138	3	4	240	1	0	0	0	0	1	0	0	0	13771	855	30	2	354	2	RSPH4A	6	116938138	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	4429386	116938138	54176929	85	43965											
ROS1	6098	broad.mit.edu	37	chr6	117709162	117709162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaggcagaagggcctaattCaaagagttcaataatatcac	16	8	8	9	0	3	2	3	0	0	2	3	2	3	2	2	2	0	2	2	2	6	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:117709162C>T	uc003pxp.1	-	13	1994	c.1795G>A	c.(1795-1797)GAA>AAA	p.E599K	ROS1_uc011ebi.1_Intron|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	599	Fibronectin type-III 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GGGCCTAATTCAAAGAGTTCA	0.438			T	GOPC|ROS1	glioblastoma|NSCLC								31	86					0	0	0	0	T	117709162	T	T	117709162	3	4	240	1	0	0	0	0	1	0	0	0	13596	835	29	2	5372	2	ROS1	6	117709162	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	771024	117709162	53405905	86	43966											
CLVS2	134829	broad.mit.edu	37	chr6	123332247	123332247	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactggagtaacttcactttCaagcaagcctctaaactcac	13	10	6	12	0	4	0	3	0	1	0	4	2	4	1	1	1	4	2	1	1	5	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:123332247C>T	uc003pzi.1	+	3	1376	c.507C>T	c.(505-507)TTC>TTT	p.F169F		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	169	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ACTTCACTTTCAAGCAAGCCT	0.413													14	75					0	0	0	0	T	123332247	T	T	123332247	2	4	240	1	0	0	0	0	0	0	0	1	3587	825	29	2		2	CLVS2	6	123332247	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	5623085	123332247	47782820	87	43967											
KIF25	3834	broad.mit.edu	37	chr6	168434601	168434601	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgtatggacagacgggcagCggaaagagctataccatgct	12	6	14	9	3	0	2	0	0	0	2	0	4	0	4	1	3	4	4	1	3	4	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr6:168434601C>T	uc003qwk.1	+	4	469	c.207C>T	c.(205-207)AGC>AGT	p.S69S	KIF25_uc003qwl.1_Silent_p.S69S	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	69	Kinesin-motor.|ATP (By similarity).				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		AGACGGGCAGCGGAAAGAGCT	0.517													15	62					0	0	0	0	T	168434601	T	T	168434601	2	4	240	1	0	0	0	0	0	0	0	1	8332	767	27	1		1	KIF25	6	168434601	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	45102354	168434601	2680466	88	43968											
BBS9	27241	broad.mit.edu	37	chr7	33296932	33296932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttttggaagatttctccCtggctttcttctgcctggtc	3	18	9	11	0	3	1	0	0	3	1	5	2	3	2	2	3	2	2	2	3	1	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:33296932C>T	uc003tdn.1	+	6	1040	c.527C>T	c.(526-528)CCT>CTT	p.P176L	BBS9_uc003tdo.1_Missense_Mutation_p.P176L|BBS9_uc003tdp.1_Missense_Mutation_p.P176L|BBS9_uc003tdq.1_Missense_Mutation_p.P176L|BBS9_uc010kwn.1_RNA|BBS9_uc011kan.1_Missense_Mutation_p.P176L|BBS9_uc011kao.1_Missense_Mutation_p.P54L	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	176					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			AGATTTCTCCCTGGCTTTCTT	0.433									Bardet-Biedl_syndrome				19	46					0	0	0	0	T	33296932	T	T	33296932	3	4	240	1	0	0	0	0	1	0	0	0	1344	681	24	4	545	4	BBS9	7	33296932	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08		33296932	125841731	89	43969											
EGFR	1956	broad.mit.edu	37	chr7	55221821	55221821	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcaaatacagctttggtGccacctgcgtgaagaagtgt	11	9	13	8	1	0	2	0	1	0	1	0	2	0	2	2	2	4	2	2	2	4	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:55221821G>A	uc003tqk.2	+	7	1111	c.865G>A	c.(865-867)GCC>ACC	p.A289T	EGFR_uc003tqh.2_Missense_Mutation_p.A289T|EGFR_uc003tqi.2_Missense_Mutation_p.A289T|EGFR_uc003tqj.2_Missense_Mutation_p.A289T|EGFR_uc010kzg.1_Missense_Mutation_p.A244T|EGFR_uc011kco.1_Missense_Mutation_p.A236T|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289T(3)|p.A289D(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGCTTTGGTGCCACCTGCGT	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			12	51					0	0	0	0	A	55221821	A	A	55221821	3	1	240	1	0	0	0	0	1	0	0	0	4989	1319	46	4	891	4	EGFR	7	55221821	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	21924889	55221821	103916842	90	43970											
GUSB	2990	broad.mit.edu	37	chr7	65439597	65439597	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcatcacttcctctgcatagGggtagtggctggtacggaaa	9	10	13	9	1	2	0	1	0	1	0	3	1	3	1	1	5	2	5	1	5	4	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:65439597G>A	uc003tun.2	-	7	1236	c.1160C>T	c.(1159-1161)CCC>CTC	p.P387L	GUSB_uc011kdt.1_Missense_Mutation_p.P241L	NM_000181	NP_000172	P08236	BGLR_HUMAN	glucuronidase, beta precursor	387					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding				0						CTCTGCATAGGGGTAGTGGCT	0.597													19	59					0	0	0	0	A	65439597	A	A	65439597	3	1	240	1	0	0	0	0	1	0	0	0	6941	1232	43	4	819	4	GUSB	7	65439597	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	10217776	65439597	93699066	91	43971											
PION	54103	broad.mit.edu	37	chr7	76950665	76950665	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgtacaagtggagaacccagGaatgaagattatgtttcctc	13	10	10	8	1	0	3	0	1	0	2	2	5	1	4	2	2	2	2	2	2	6	3	rs6950836		TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:76950665G>A	uc003ugf.2	-	25	2058	c.1979C>T	c.(1978-1980)TCC>TTC	p.S660F	PION_uc011kgo.1_Intron|PION_uc003ugd.2_Missense_Mutation_p.S54F	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	660					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						GAGAACCCAGGAATGAAGATT	0.423													5	21					0	0	0	0	A	76950665	A	A	76950665	3	1	240	1	0	0	0	0	1	0	0	0	11989	1174	41	2	613	2	PION	7	76950665	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	11511068	76950665	82187998	92	43972											
GNAT3	346562	broad.mit.edu	37	chr7	80141221	80141221	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggctgactccttgctctCtgaactaattccacttccca	7	15	5	14	0	1	2	0	2	1	0	5	2	4	2	3	1	2	2	3	1	2	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:80141221C>T	uc011kgu.1	-	1	22	c.22G>A	c.(22-24)GAG>AAG	p.E8K	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	8					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						TCCTTGCTCTCTGAACTAATT	0.418													9	18					0	0	0	0	T	80141221	T	T	80141221	3	4	240	1	0	0	0	0	1	0	0	0	6550	922	32	2	1072	2	GNAT3	7	80141221	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	3190556	80141221	78997442	93	43973											
OCM2	4951	broad.mit.edu	37	chr7	97617811	97617811	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctgactggctgacatcttGgagaggcctgacgtctggaa	9	9	13	10	1	2	4	0	3	2	1	2	6	2	5	2	4	0	1	2	4	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:97617811G>A	uc003upc.2	-	2	111	c.111C>T	c.(109-111)TCC>TCT	p.S37S		NM_006188	NP_006179	P0CE71	OCM2_HUMAN	oncomodulin-like	37							calcium ion binding				0						CTGACATCTTGGAGAGGCCTG	0.458													42	128					0	0	0	0	A	97617811	A	A	97617811	2	1	240	1	0	0	0	0	0	0	0	1	10876	1335	47	4		4	OCM2	7	97617811	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	17476590	97617811	61520852	94	43974											
PDAP1	11333	broad.mit.edu	37	chr7	99001128	99001128	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttctttttgctcctcttcttCctgtttcagaaatggacaac	7	18	5	11	0	4	1	1	0	3	1	6	2	6	2	2	1	2	2	2	1	2	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:99001128C>T	uc003uqe.2	-	3	227	c.106G>A	c.(106-108)GAA>AAA	p.E36K		NM_014891	NP_055706	Q13442	HAP28_HUMAN	PDGFA associated protein 1	36					cell proliferation|signal transduction						0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)		Becaplermin(DB00102)	TCCTCTTCTTCCTGTTTCAGA	0.453													18	72					0	0	0	0	T	99001128	T	T	99001128	3	4	240	1	0	0	0	0	1	0	0	0	11667	869	30	2	455	2	PDAP1	7	99001128	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1383317	99001128	60137535	95	43975											
GNB2	2783	broad.mit.edu	37	chr7	100276155	100276155	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcatcacctctgttgccttCtcgcgcagcggacggctgct	4	10	12	15	4	3	0	1	0	2	0	4	1	3	1	2	3	3	5	2	3	0	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:100276155C>T	uc003uwb.2	+	9	1107	c.834C>T	c.(832-834)TTC>TTT	p.F278F	GNB2_uc003uwc.2_Silent_p.F234F|GNB2_uc010lhd.2_Silent_p.F234F|GNB2_uc010lhe.2_Silent_p.F234F|GNB2_uc003uwd.2_Silent_p.F178F|GNB2_uc010lhf.2_Silent_p.F178F|GNB2_uc003uwe.2_Silent_p.F278F|GNB2_uc003uwf.2_Silent_p.F178F	NM_005273	NP_005264	P62879	GBB2_HUMAN	guanine nucleotide-binding protein, beta-2	278	WD 6.				cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	perinuclear region of cytoplasm|plasma membrane	GTPase activity|GTPase binding|signal transducer activity			ovary(2)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)	Ovarian(593;0.238)				CTGTTGCCTTCTCGCGCAGCG	0.622													19	48					0	0	0	0	T	100276155	T	T	100276155	2	4	240	1	0	0	0	0	0	0	0	1	6554	912	32	2		2	GNB2	7	100276155	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1275027	100276155	58862508	96	43976											
GIGYF1	64599	broad.mit.edu	37	chr7	100280033	100280033	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcctgggaatgccctgcagCagcttcagcagcttctcttc	6	10	11	14	0	2	0	1	0	1	0	4	1	2	1	2	2	6	5	2	2	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:100280033C>T	uc003uwg.1	-	21	3682	c.2673G>A	c.(2671-2673)CTG>CTA	p.L891L		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	891										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TGCCCTGCAGCAGCTTCAGCA	0.637													8	42					0	0	0	0	T	100280033	T	T	100280033	2	4	240	1	0	0	0	0	0	0	0	1	6414	697	25	4		4	GIGYF1	7	100280033	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	3878	100280033	58858630	97	43977											
CUX1	1523	broad.mit.edu	37	chr7	101559408	101559408	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccaacagagagaactcgatgCcaccgcaacggtattggcga	13	5	11	12	4	0	2	0	0	0	2	1	5	0	2	3	2	4	2	3	2	4	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:101559408C>A	uc003uyx.3	+	2	82	c.44C>A	c.(43-45)GCC>GAC	p.A15D	CUX1_uc003uys.3_Missense_Mutation_p.A26D|CUX1_uc003uyt.2_Missense_Mutation_p.A26D|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Missense_Mutation_p.A26D|CUX1_uc003uyv.2_Missense_Mutation_p.A26D|CUX1_uc003uyu.2_Missense_Mutation_p.A26D	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	15	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GAACTCGATGCCACCGCAACG	0.498													39	146					1.15183e-24	4.20181e-24	1	0	A	101559408	A	A	101559408	3	1	240	1	0	0	0	0	1	0	0	0	4081	739	26	4	117	4	CUX1	7	101559408	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1279375	101559408	57579255	98	43978											
CTTNBP2	83992	broad.mit.edu	37	chr7	117375087	117375087	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtcggagccctggagacaGgccttggcgatggttcccat	8	8	14	11	2	0	1	0	0	0	1	2	4	1	2	3	5	1	1	3	5	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:117375087G>A	uc003vjf.2	-	16	3848	c.3756C>T	c.(3754-3756)GCC>GCT	p.A1252A		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1252										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CCTGGAGACAGGCCTTGGCGA	0.537													6	45					0	0	0	0	A	117375087	A	A	117375087	2	1	240	1	0	0	0	0	0	0	0	1	4062	987	35	4		4	CTTNBP2	7	117375087	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	15815679	117375087	41763576	99	43979											
LRRC4	64101	broad.mit.edu	37	chr7	127669962	127669962	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatgacccagagcttcttGagggagctcaggccatggaa	10	9	12	10	0	3	3	2	2	1	1	3	5	3	5	2	3	2	2	2	3	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:127669962G>C	uc003vmk.2	-	2	869	c.732C>G	c.(730-732)CTC>CTG	p.L244L	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	244	Extracellular (Potential).|LRR 8.					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		AGAGCTTCTTGAGGGAGCTCA	0.572													17	40					0	0	0	0	C	127669962	C	C	127669962	2	2	240	1	0	0	0	0	0	0	0	1	9047	1277	45	2		2	LRRC4	7	127669962	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	10294875	127669962	31468701	100	43980			2	67		3	3	232	G		2.003212e-06
LRRC4	64101	broad.mit.edu	37	chr7	127670131	127670131	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcccctcaaaagctccctcaGagatatactccagcttcttg	10	10	6	15	0	3	1	2	0	1	1	5	2	5	1	4	0	3	2	4	0	4	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:127670131G>C	uc003vmk.2	-	2	700	c.563C>G	c.(562-564)TCT>TGT	p.S188C	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	188	LRR 5.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		AGCTCCCTCAGAGATATACTC	0.557													14	57					0	0	0	0	C	127670131	C	C	127670131	3	2	240	1	0	0	0	0	1	0	0	0	9047	942	33	2	1402	2	LRRC4	7	127670131	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	169	127670131	31468532	101	43981			2	67		3	3	232	G		2.003212e-06
LRRC4	64101	broad.mit.edu	37	chr7	127670193	127670193	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagggagggcacccggttGaaggcgtaagaggggatgct	10	6	19	6	2	0	3	0	2	0	1	0	5	0	5	1	6	1	4	1	6	2	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:127670193G>A	uc003vmk.2	-	2	638	c.501C>T	c.(499-501)TTC>TTT	p.F167F	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	167	LRR 4.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GCACCCGGTTGAAGGCGTAAG	0.572													20	79					0	0	0	0	A	127670193	A	A	127670193	2	1	240	1	0	0	0	0	0	0	0	1	9047	1281	45	2		2	LRRC4	7	127670193	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	62	127670193	31468470	102	43982			2	67		3	3	232	G		2.003212e-06
JHDM1D	80853	broad.mit.edu	37	chr7	139801957	139801957	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttaactggtttgccgttttCctcctttaagaattaaaatc	10	18	5	8	1	0	1	0	0	0	1	3	1	2	1	3	1	2	2	3	1	5	8			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:139801957C>T	uc003vvm.2	-	12	1436	c.1432G>A	c.(1432-1434)GAA>AAA	p.E478K	JHDM1D_uc010lng.2_RNA	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	478					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					TTGCCGTTTTCCTCCTTTAAG	0.348													25	62					0	0	0	0	T	139801957	T	T	139801957	3	4	240	1	0	0	0	0	1	0	0	0	7987	864	30	2	1429	2	JHDM1D	7	139801957	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	12131764	139801957	19336706	103	43983											
CNTNAP2	26047	broad.mit.edu	37	chr7	148112633	148112633	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcggagtcggcagagagcgcGgacgccgccatcatgaacaa	11	3	15	12	6	1	2	1	1	0	1	2	5	1	4	2	3	2	1	2	3	2	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:148112633G>A	uc003weu.1	+	24	4437	c.3921G>A	c.(3919-3921)GCG>GCA	p.A1307A	CNTNAP2_uc003wev.1_Silent_p.A84A	NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1307	Cytoplasmic (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAGAGAGCGCGGACGCCGCCA	0.552										HNSCC(39;0.1)			15	58					0	0	0	0	A	148112633	A	A	148112633	2	1	240	1	0	0	0	0	0	0	0	1	3662	1103	39	1		1	CNTNAP2	7	148112633	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	8310676	148112633	11026030	104	43984											
EZH2	2146	broad.mit.edu	37	chr7	148515125	148515125	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctactgttattgggaagccGtcctcttctgcggcctcctg	4	13	11	13	2	2	0	0	0	2	0	4	1	4	1	4	2	3	2	4	2	3	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr7:148515125G>A	uc003wfd.1	-	10	1235	c.1069C>T	c.(1069-1071)CGG>TGG	p.R357W	EZH2_uc011kug.1_Missense_Mutation_p.R348W|EZH2_uc003wfb.1_Missense_Mutation_p.R362W|EZH2_uc003wfc.1_Missense_Mutation_p.R318W|EZH2_uc011kuh.1_Missense_Mutation_p.R348W|EZH2_uc011kui.1_Missense_Mutation_p.R357W|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	357					negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			TTGGGAAGCCGTCCTCTTCTG	0.537			Mis		DLBCL								25	104					0	0	0	0	A	148515125	A	A	148515125	3	1	240	1	0	0	0	0	1	0	0	0	5359	1144	40	1	1215	1	EZH2	7	148515125	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	402492	148515125	10623538	105	43985											
DEFA4	1669	broad.mit.edu	37	chr8	6794389	6794389	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggacctggagggctaccaaGagaatagcagcgaggagggc	12	3	17	9	2	0	1	0	0	0	1	0	6	0	4	2	5	3	2	2	5	4	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:6794389G>T	uc003wqu.1	-	2	84	c.33C>A	c.(31-33)CTC>CTA	p.L11L		NM_001925	NP_001916	P12838	DEF4_HUMAN	defensin, alpha 4 preproprotein	11					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				large_intestine(1)	1				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		GGGCTACCAAGAGAATAGCAG	0.602													8	37					0.000157383	0.000510971	1	0	T	6794389	T	T	6794389	2	4	240	1	0	0	0	0	0	0	0	1	4408	929	33	2		2	DEFA4	8	6794389	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08		6794389	139569633	106	43986											
SH2D4A	63898	broad.mit.edu	37	chr8	19231062	19231062	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcagggagtggtgaggacActgtccagctctgcccaaga	11	7	13	10	0	2	2	1	1	1	1	3	4	3	4	2	3	2	1	2	3	2	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:19231062A>G	uc003wzb.2	+	8	1275	c.939A>G	c.(937-939)ACA>ACG	p.T313T	SH2D4A_uc011kym.1_Silent_p.T268T|SH2D4A_uc003wzc.2_Silent_p.T313T	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	313						cytoplasm|nucleus	protein binding				0				Colorectal(111;0.0732)		TGGTGAGGACACTGTCCAGCT	0.408													10	28					0	0	0	0	G	19231062	G	G	19231062	2	3	240	1	0	0	0	0	0	0	0	1	14300	146	6	5		5	SH2D4A	8	19231062	Silent	SNP	A	TCGA-CV-7252-01A-11D-2012-08	12436673	19231062	127132960	107	43987											
CSGALNACT1	55790	broad.mit.edu	37	chr8	19362961	19362961	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcattcacctctgccttgtCcacctgcgagtgcaggaagg	8	9	11	13	1	2	0	1	0	1	0	3	2	3	1	4	2	4	2	4	2	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:19362961C>A	uc011kyn.1	-	4	1449	c.385G>T	c.(385-387)GAC>TAC	p.D129Y	CSGALNACT1_uc011kyo.1_Missense_Mutation_p.D129Y|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Missense_Mutation_p.D128Y|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	129	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		TCTGCCTTGTCCACCTGCGAG	0.597													25	73					3.65163e-15	1.29334e-14	1	0	A	19362961	A	A	19362961	3	1	240	1	0	0	0	0	1	0	0	0	3955	855	30	2	1241	2	CSGALNACT1	8	19362961	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	131899	19362961	127001061	108	43988											
PTK2B	2185	broad.mit.edu	37	chr8	27289833	27289833	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcaggtgcctcccgctggaGgagggccaggcagtacttca	8	7	14	12	1	2	0	2	0	0	0	3	2	3	2	3	5	2	3	3	5	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:27289833G>A	uc003xfn.1	+	15	1750	c.942G>A	c.(940-942)GAG>GAA	p.E314E	PTK2B_uc003xfo.1_Silent_p.E314E|PTK2B_uc003xfp.1_Silent_p.E314E|PTK2B_uc003xfq.1_Silent_p.E314E|PTK2B_uc010luq.1_Silent_p.E85E|PTK2B_uc003xfr.1_Silent_p.E60E	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	314	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TCCCGCTGGAGGAGGGCCAGG	0.622													7	28					0	0	0	0	A	27289833	A	A	27289833	2	1	240	1	0	0	0	0	0	0	0	1	12826	991	35	4		4	PTK2B	8	27289833	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	7926872	27289833	119074189	109	43989											
PROSC	11212	broad.mit.edu	37	chr8	37623261	37623261	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagaaaaagcatcaaatccCaaagtaagtagatagctgaa	20	7	7	7	0	1	3	1	1	0	2	2	3	2	3	1	0	2	4	1	0	9	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:37623261C>A	uc003xkh.2	+	3	317	c.240C>A	c.(238-240)CCC>CCA	p.P80P		NM_007198	NP_009129	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog	80							pyridoxal phosphate binding			central_nervous_system(1)	1		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	CATCAAATCCCAAAGTAAGTA	0.383													6	222					0.00116845	0.00375599	1	0	A	37623261	A	A	37623261	2	1	240	1	0	0	0	0	0	0	0	1	12621	581	21	4		4	PROSC	8	37623261	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	10333428	37623261	108740761	110	43990											
ADRB3	155	broad.mit.edu	37	chr8	37823854	37823854	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtggccagcaccgccagcGccagcagggccccggctagg	6	2	16	17	4	0	0	0	0	0	0	0	0	0	0	6	5	3	3	6	5	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:37823854G>A	uc003xkr.1	-	1	331	c.134C>T	c.(133-135)GCG>GTG	p.A45V		NM_000025	NP_000016	P13945	ADRB3_HUMAN	adrenergic, beta-3-, receptor	45	Helical; Name=1; (By similarity).				carbohydrate metabolic process|energy reserve metabolic process|positive regulation of MAPKKK cascade	integral to plasma membrane|receptor complex	beta3-adrenergic receptor activity|protein homodimerization activity			lung(2)	2	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)		Norepinephrine(DB00368)|Pindolol(DB00960)|Propranolol(DB00571)	CACCGCCAGCGCCAGCAGGGC	0.697													8	22					0	0	0	0	A	37823854	A	A	37823854	3	1	240	1	0	0	0	0	1	0	0	0	342	1087	38	1	1100	1	ADRB3	8	37823854	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	200593	37823854	108540168	111	43991											
MATN2	4147	broad.mit.edu	37	chr8	99039681	99039681	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attgacctggtctttgtgatCgatggatccaagagtcttgg	8	14	12	7	1	2	3	0	2	2	1	4	5	3	4	2	3	0	0	2	3	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:99039681C>T	uc003yic.2	+	14	2211	c.1980C>T	c.(1978-1980)ATC>ATT	p.I660I	MATN2_uc010mbh.1_Silent_p.I619I|MATN2_uc003yid.2_Silent_p.I660I|MATN2_uc003yie.1_Silent_p.I660I|MATN2_uc010mbi.1_Silent_p.I493I|MATN2_uc010mbj.1_Intron|RPL30_uc010mbk.1_Intron	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	660	VWFA 2.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TCTTTGTGATCGATGGATCCA	0.403													26	85					0	0	0	0	T	99039681	T	T	99039681	2	4	240	1	0	0	0	0	0	0	0	1	9387	874	31	1		1	MATN2	8	99039681	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	61215827	99039681	47324341	112	43992											
COL14A1	7373	broad.mit.edu	37	chr8	121267542	121267542	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaccagcttgtgtgcccactGgcaggtacatcgccatgcca	8	8	11	14	1	0	0	0	0	0	0	1	1	0	0	4	2	4	3	4	2	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:121267542G>A	uc003yox.2	+	23	3081	c.2816G>A	c.(2815-2817)TGG>TAG	p.W939*	COL14A1_uc003yoy.2_Nonsense_Mutation_p.W617*	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	939	Fibronectin type-III 8.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGTGCCCACTGGCAGGTACAT	0.438													36	96					0	0	0	0	A	121267542	A	A	121267542	4	1	240	1	0	0	0	0	0	1	0	0	3686	1357	47	4	2902	4	COL14A1	8	121267542	Nonsense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	22227861	121267542	25096480	113	43993											
ARC	23237	broad.mit.edu	37	chr8	143695543	143695543	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcggcccggcacttcccgatCtgcaggatcacgttgggctt	5	10	12	14	4	2	0	1	0	1	0	4	2	3	1	2	4	1	4	2	4	0	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:143695543C>G	uc003ywn.1	-	1	291	c.90G>C	c.(88-90)CAG>CAC	p.Q30H		NM_015193	NP_056008	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated	30					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)	1	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				ACTTCCCGATCTGCAGGATCA	0.726													4	19					0	0	0	0	G	143695543	G	G	143695543	3	3	240	1	0	0	0	0	1	0	0	0	841	912	32	2	1104	2	ARC	8	143695543	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	22428001	143695543	2668479	114	43994											
JRK	8629	broad.mit.edu	37	chr8	143746149	143746149	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccttctgcctcccttccCgctaccccccagctggcggc	2	8	7	24	2	1	0	0	0	1	0	3	0	3	0	8	2	3	2	8	2	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:143746149C>T	uc003ywo.2	-	2	1843	c.1329G>A	c.(1327-1329)GCG>GCA	p.A443A	JRK_uc003ywp.2_Silent_p.A443A|JRK_uc010mew.1_Silent_p.A443A	NM_001077527	NP_001070995			jerky isoform b												0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				cctcccttcccgctacccccc	0													5	12					0	0	0	0	T	143746149	T	T	143746149	2	4	240	1	0	0	0	0	0	0	0	1	8003	639	23	1		1	JRK	8	143746149	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	50606	143746149	2617873	115	43995											
GPIHBP1	338328	broad.mit.edu	37	chr8	144297245	144297245	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgccagtccagcctgtGcaatgtcccaccctggcaaa	8	8	9	16	0	0	0	0	0	0	0	2	0	2	0	5	1	4	3	5	1	2	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr8:144297245G>A	uc003yxu.1	+	4	482	c.407G>A	c.(406-408)TGC>TAC	p.C136Y		NM_178172	NP_835466	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high	136	UPAR/Ly6.				cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity				0	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TCCAGCCTGTGCAATGTCCCA	0.672													22	65					0	0	0	0	A	144297245	A	A	144297245	3	1	240	1	0	0	0	0	1	0	0	0	6650	1319	46	4	421	4	GPIHBP1	8	144297245	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	551096	144297245	2066777	116	43996											
FAM108B1	51104	broad.mit.edu	37	chr9	74489807	74489807	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgaaacactcaatagcatCtttttctctagaagaatact	15	13	4	9	0	3	3	1	1	2	2	4	3	3	3	0	0	3	1	0	0	7	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr9:74489807C>A	uc004aim.1	-	2	792	c.190G>T	c.(190-192)GAT>TAT	p.D64Y	FAM108B1_uc004ail.2_Missense_Mutation_p.D64Y	NM_001025780	NP_001020951	Q5VST6	F108B_HUMAN	family with sequence similarity 108, member B1	64						extracellular region	hydrolase activity				0						TCAATAGCATCTTTTTCTCTA	0.413													7	70					5.18039e-06	1.72798e-05	1	0	A	74489807	A	A	74489807	3	1	240	1	0	0	0	0	1	0	0	0	5420	913	32	2	719	2	FAM108B1	9	74489807	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08		74489807	66723624	117	43997											
CRB2	286204	broad.mit.edu	37	chr9	126136903	126136903	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcctgaatgtcacctgcctCgatggcagcccatgtgaggg	8	8	13	12	1	1	2	1	2	0	0	2	3	1	2	4	2	3	1	4	2	1	0	rs148933240	byFrequency	TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr9:126136903C>T	uc004bnx.1	+	11	3527	c.3435C>T	c.(3433-3435)CTC>CTT	p.L1145L		NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	1145	Extracellular (Potential).|EGF-like 14.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						TCACCTGCCTCGATGGCAGCC	0.657													20	28					0	0	0	0	T	126136903	T	T	126136903	2	4	240	1	0	0	0	0	0	0	0	1	3864	871	31	1		1	CRB2	9	126136903	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	51647096	126136903	15076528	118	43998											
LAMC3	10319	broad.mit.edu	37	chr9	133932455	133932455	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtgctccgggatacaagagGgagatgccacaggggggtcc	9	6	17	9	1	0	2	0	0	0	2	2	4	2	3	3	5	3	1	3	5	2	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr9:133932455G>A	uc004caa.1	+	12	2177	c.2079G>A	c.(2077-2079)AGG>AGA	p.R693R		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	693	Laminin EGF-like 5; second part.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GATACAAGAGGGAGATGCCAC	0.612													23	67					0	0	0	0	A	133932455	A	A	133932455	2	1	240	1	0	0	0	0	0	0	0	1	8656	1223	43	4		4	LAMC3	9	133932455	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	7795552	133932455	7280976	119	43999											
MYO3A	53904	broad.mit.edu	37	chr10	26377303	26377303	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagatttctgaatatctcCtggaaaaatcccgagttatc	13	12	6	10	1	2	2	0	1	2	1	5	4	3	3	2	1	0	1	2	1	5	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:26377303C>T	uc001isn.2	+	15	1891	c.1531C>T	c.(1531-1533)CTG>TTG	p.L511L	MYO3A_uc009xko.1_Silent_p.L511L|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Silent_p.L511L	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	511	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TGAATATCTCCTGGAAAAATC	0.343													4	36					0	0	0	0	T	26377303	T	T	26377303	2	4	240	1	0	0	0	0	0	0	0	1	10129	680	24	4		4	MYO3A	10	26377303	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08		26377303	109157444	120	44000											
ITGB1	3688	broad.mit.edu	37	chr10	33199181	33199181	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacaacatgaaccatgacctCgttgttcccattcactgaat	12	11	5	13	1	1	3	1	3	0	0	3	3	2	3	3	0	2	2	3	0	3	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:33199181C>T	uc001iws.3	-	14	2270	c.2134G>A	c.(2134-2136)GAG>AAG	p.E712K	ITGB1_uc001iwp.3_Missense_Mutation_p.E712K|ITGB1_uc001iwq.3_Missense_Mutation_p.E712K|ITGB1_uc001iwr.3_Missense_Mutation_p.E712K|ITGB1_uc001iwt.3_Missense_Mutation_p.E712K|ITGB1_uc001iwu.1_Missense_Mutation_p.E712K	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	712	Extracellular (Potential).				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				ACCATGACCTCGTTGTTCCCA	0.423													4	30					0	0	0	0	T	33199181	T	T	33199181	3	4	240	1	0	0	0	0	1	0	0	0	7929	893	31	1	512	1	ITGB1	10	33199181	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	6821878	33199181	102335566	121	44001											
ITGB1	3688	broad.mit.edu	37	chr10	33200509	33200509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatctgtccgttgctggcttCacaagtactagtatccaaag	10	12	9	10	1	2	0	1	0	1	0	4	1	4	0	2	1	2	5	2	1	5	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:33200509C>T	uc001iws.3	-	13	1934	c.1798G>A	c.(1798-1800)GAA>AAA	p.E600K	ITGB1_uc001iwp.3_Missense_Mutation_p.E600K|ITGB1_uc001iwq.3_Missense_Mutation_p.E600K|ITGB1_uc001iwr.3_Missense_Mutation_p.E600K|ITGB1_uc001iwt.3_Missense_Mutation_p.E600K|ITGB1_uc001iwu.1_Missense_Mutation_p.E600K	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	600	Extracellular (Potential).|Cysteine-rich tandem repeats.|IV.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TTGCTGGCTTCACAAGTACTA	0.493													27	138					0	0	0	0	T	33200509	T	T	33200509	3	4	240	1	0	0	0	0	1	0	0	0	7929	835	29	2	852	2	ITGB1	10	33200509	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1328	33200509	102334238	122	44002											
AGAP8	728404	broad.mit.edu	37	chr10	51225526	51225526	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgggaaaggcgggtgccaaGactgtggtggattcctgagc	9	7	17	8	2	0	2	0	1	0	1	1	4	1	4	2	5	2	0	2	5	2	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:51225526G>C	uc001jij.2	-	7	1582	c.1456C>G	c.(1456-1458)CTT>GTT	p.L486V	PARG_uc001jih.2_Intron|PARG_uc001jif.2_Intron|PARG_uc001jig.2_Intron|PARG_uc010qgv.1_Intron|PARG_uc009xoi.2_Intron|PARG_uc010qgw.1_Intron|PARG_uc009xoj.2_Intron|PARG_uc010qgx.1_Intron|AGAP8_uc009xom.2_Missense_Mutation_p.L401V|AGAP8_uc001jik.2_Missense_Mutation_p.L470V|AGAP8_uc010qgy.1_Missense_Mutation_p.L509V|uc001jil.1_5'Flank	NM_001077686	NP_001071154	Q5SRD3	AGAP8_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	486	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						CGGGTGCCAAGACTGTGGTGG	0.522													5	290					0	0	0	0	C	51225526	C	C	51225526	3	2	240	1	0	0	0	0	1	0	0	0	374	942	33	2	539	2	AGAP8	10	51225526	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	18025017	51225526	84309221	123	44003											
AGAP7	653268	broad.mit.edu	37	chr10	51465428	51465428	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccagcccggtgtccatgTccttggataggccatcgctt	6	10	10	15	2	0	0	0	0	0	0	3	1	2	1	5	3	1	1	5	3	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:51465428T>C	uc001jio.2	-	7	1154	c.1028A>G	c.(1027-1029)GAC>GGC	p.D343G	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron	NM_001077685	NP_001071153	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	343	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						GGTGTCCATGTCCTTGGATAG	0.557													48	221					0	0	0	0	C	51465428	C	C	51465428	3	2	240	1	0	0	0	0	1	0	0	0	373	1667	58	5	967	5	AGAP7	10	51465428	Missense_Mutation	SNP	T	TCGA-CV-7252-01A-11D-2012-08	239902	51465428	84069319	124	44004											
LRRTM3	347731	broad.mit.edu	37	chr10	68687810	68687810	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggctctcccaaagccgaCgtttaagcccaagctcccca	10	6	8	17	2	1	0	0	0	1	0	3	1	2	0	5	1	3	3	5	1	3	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:68687810C>A	uc001jmz.1	+	2	1686	c.1136C>A	c.(1135-1137)ACG>AAG	p.T379K	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.T379K	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	379	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CCAAAGCCGACGTTTAAGCCC	0.577													17	58					1.99824e-07	6.78147e-07	1	0	A	68687810	A	A	68687810	3	1	240	1	0	0	0	0	1	0	0	0	9091	536	19	3	1142	3	LRRTM3	10	68687810	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	17222382	68687810	66846937	125	44005											
COL13A1	1305	broad.mit.edu	37	chr10	71631932	71631932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctacgtaaacgtcactcttCatttcagggtcccactggaa	10	11	7	13	2	4	0	3	0	1	0	5	1	5	1	2	2	2	1	2	2	4	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:71631932C>T	uc001jpr.1	+	3	901	c.365C>T	c.(364-366)GCA>GTA	p.A122V	COL13A1_uc001jqj.1_Missense_Mutation_p.A122V|COL13A1_uc001jps.1_Missense_Mutation_p.A122V|COL13A1_uc001jpt.1_Missense_Mutation_p.A122V|COL13A1_uc001jpu.1_Missense_Mutation_p.A122V|COL13A1_uc001jpv.1_Missense_Mutation_p.A122V|COL13A1_uc001jpx.1_Missense_Mutation_p.A122V|COL13A1_uc001jpw.1_Missense_Mutation_p.A122V|COL13A1_uc001jpy.1_Intron|COL13A1_uc001jpz.1_Intron|COL13A1_uc001jqa.1_Intron|COL13A1_uc001jqc.1_Missense_Mutation_p.A122V|COL13A1_uc001jqb.1_Missense_Mutation_p.A122V|COL13A1_uc001jql.2_Intron|COL13A1_uc001jqd.1_Missense_Mutation_p.A122V|COL13A1_uc001jqe.1_Missense_Mutation_p.A122V|COL13A1_uc001jqf.1_Missense_Mutation_p.A122V|COL13A1_uc001jqg.1_Missense_Mutation_p.A122V|COL13A1_uc001jqh.1_Missense_Mutation_p.A122V|COL13A1_uc001jqi.1_Missense_Mutation_p.A122V|COL13A1_uc010qjf.1_Intron|COL13A1_uc001jqk.1_Intron	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	122	Extracellular (Potential).|Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	CGTCACTCTTCATTTCAGGGT	0.348													8	36					0	0	0	0	T	71631932	T	T	71631932	3	4	240	1	0	0	0	0	1	0	0	0	3685	841	29	2		2	COL13A1	10	71631932	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	2944122	71631932	63902815	126	44006											
C10orf54	64115	broad.mit.edu	37	chr10	73515124	73515124	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aggaatactcacggcggttgGaggctgcctgcctttgcttg	6	11	14	10	2	1	0	1	0	0	0	1	2	1	2	2	5	4	3	2	5	2	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:73515124G>C	uc001jsd.2	-	4	809	c.668C>G	c.(667-669)TCC>TGC	p.S223C	CDH23_uc001jrx.3_Intron|C10orf54_uc001jse.2_Missense_Mutation_p.S91C|C10orf54_uc009xqm.2_Missense_Mutation_p.S61C	NM_022153	NP_071436	Q9H7M9	GI24_HUMAN	platelet receptor Gi24 precursor	223	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)|central_nervous_system(1)	3						ACGGCGGTTGGAGGCTGCCTG	0.637													7	18					0	0	0	0	C	73515124	C	C	73515124	3	2	240	1	0	0	0	0	1	0	0	0	1613	1174	41	2	283	2	C10orf54	10	73515124	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1883192	73515124	62019623	127	44007											
CDH23	64072	broad.mit.edu	37	chr10	73537541	73537541	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgagggcccagacacgctCaacaccagcctcatcaccat	12	5	8	16	1	3	2	3	1	0	1	3	3	3	2	4	1	2	1	4	1	1	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:73537541C>T	uc001jrx.3	+	37	5327	c.4950C>T	c.(4948-4950)CTC>CTT	p.L1650L		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1650	Cadherin 16.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CAGACACGCTCAACACCAGCC	0.582													13	38					0	0	0	0	T	73537541	T	T	73537541	2	4	240	1	0	0	0	0	0	0	0	1	3123	813	29	2		2	CDH23	10	73537541	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	22417	73537541	61997206	128	44008											
CYP26C1	340665	broad.mit.edu	37	chr10	94828253	94828253	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccgttcggcggcggtgcGcgcagctgcctcggccagga	4	6	16	15	7	0	0	0	0	0	0	3	1	1	1	3	5	3	3	3	5	0	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:94828253G>A	uc010qns.1	+	6	1368	c.1368G>A	c.(1366-1368)GCG>GCA	p.A456A	CYP26C1_uc009xud.2_RNA	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	456					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)				GCGGCGGTGCGCGCAGCTGCC	0.706													5	24					0	0	0	0	A	94828253	A	A	94828253	2	1	240	1	0	0	0	0	0	0	0	1	4174	1074	38	1		1	CYP26C1	10	94828253	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	21290712	94828253	40706494	129	44009											
ENTPD7	57089	broad.mit.edu	37	chr10	101458317	101458317	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcagaagacaggtctgaGtcccgacaatccatttctgg	10	10	11	10	1	3	3	1	1	2	2	5	4	5	3	2	3	0	0	2	3	2	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:101458317G>A	uc001kqa.3	+	10	1215	c.1037G>A	c.(1036-1038)AGT>AAT	p.S346N	ENTPD7_uc009xwl.2_Missense_Mutation_p.S348N	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	346	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		ACAGGTCTGAGTCCCGACAAT	0.448													15	43					0	0	0	0	A	101458317	A	A	101458317	3	1	240	1	0	0	0	0	1	0	0	0	5168	1029	36	4	1071	4	ENTPD7	10	101458317	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	6630064	101458317	34076430	130	44010											
FAM178A	55719	broad.mit.edu	37	chr10	102676401	102676401	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattgtctatcactgggacaGagcagtttgaaaggaaacta	14	10	11	6	0	2	2	1	1	1	1	2	5	2	4	0	2	2	2	0	2	4	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:102676401G>C	uc001krt.3	+	3	801	c.259G>C	c.(259-261)GAG>CAG	p.E87Q	FAM178A_uc001krr.1_Missense_Mutation_p.E87Q|FAM178A_uc001krs.2_Missense_Mutation_p.E87Q|FAM178A_uc001kru.1_Missense_Mutation_p.E23Q	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	87											0						CACTGGGACAGAGCAGTTTGA	0.373													10	26					0	0	0	0	C	102676401	C	C	102676401	3	2	240	1	0	0	0	0	1	0	0	0	5531	943	33	2	269	2	FAM178A	10	102676401	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1218084	102676401	32858346	131	44011											
HPS6	79803	broad.mit.edu	37	chr10	103826348	103826348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaagagctggagacccgaGggaatcttcgtctgctttca	10	9	13	9	2	3	2	1	0	2	2	4	6	3	4	1	3	2	2	1	3	2	2	rs140222296		TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:103826348G>A	uc001kuj.2	+	1	1202	c.1117G>A	c.(1117-1119)GGG>AGG	p.G373R		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	373						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		GGAGACCCGAGGGAATCTTCG	0.572									Hermansky-Pudlak_syndrome				11	60					0	0	0	0	A	103826348	A	A	103826348	3	1	240	1	0	0	0	0	1	0	0	0	7382	1000	35	4	1119	4	HPS6	10	103826348	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1149947	103826348	31708399	132	44012											
GPAM	57678	broad.mit.edu	37	chr10	113933472	113933472	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatacctgatcattgccggtGagacagtggcaaccatttct	11	11	9	10	1	2	2	1	2	1	1	2	3	2	2	3	2	3	1	3	2	3	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr10:113933472G>A	uc009xxy.1	-	7	743	c.545C>T	c.(544-546)TCA>TTA	p.S182L	GPAM_uc001kzp.2_Missense_Mutation_p.S182L|GPAM_uc001kzq.1_Missense_Mutation_p.S182L	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	182					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		CATTGCCGGTGAGACAGTGGC	0.403													19	47					0	0	0	0	A	113933472	A	A	113933472	3	1	240	1	0	0	0	0	1	0	0	0	6626	1294	45	2	2005	2	GPAM	10	113933472	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	10107124	113933472	21601275	133	44013											
BET1L	51272	broad.mit.edu	37	chr11	205338	205338	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaagaagtaggagaggatGaagaaggccacaattagacc	18	4	13	6	0	0	5	0	1	0	4	0	8	0	6	2	3	0	1	2	3	7	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:205338G>A	uc001loe.2	-	4	401	c.300C>T	c.(298-300)TTC>TTT	p.F100F	BET1L_uc001lod.2_3'UTR	NM_001098787	NP_001092257	Q9NYM9	BET1L_HUMAN	blocked early in transport 1 homolog (S.	100	Helical; Anchor for type IV membrane protein; (Potential).				protein transport|retrograde transport, endosome to Golgi	endosome|SNARE complex	SNAP receptor activity				0		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;4.2e-27)|Epithelial(43;2.8e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.7e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGGAGAGGATGAAGAAGGCCA	0.567													9	28					0	0	0	0	A	205338	A	A	205338	2	1	240	1	0	0	0	0	0	0	0	1	1411	1281	45	2		2	BET1L	11	205338	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08		205338	134801178	134	44014											
STK33	65975	broad.mit.edu	37	chr11	8478907	8478907	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccattattgtgaagatatgcTatagctgatgcgagactttg	11	14	10	6	1	0	4	0	2	0	2	0	5	0	4	1	0	3	2	1	0	5	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:8478907T>A	uc001mgi.1	-	5	1597	c.678A>T	c.(676-678)ATA>ATT	p.I226I	STK33_uc001mgj.1_Silent_p.I226I|STK33_uc001mgk.1_Silent_p.I226I|STK33_uc010rbn.1_Silent_p.I185I|STK33_uc001mgl.3_Silent_p.I39I|STK33_uc009yfp.2_Intron	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	226	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		GAAGATATGCTATAGCTGATG	0.388													12	39					0	0	0	0	A	8478907	A	A	8478907	2	1	240	1	0	0	0	0	0	0	0	1	15366	1512	53	5		5	STK33	11	8478907	Silent	SNP	T	TCGA-CV-7252-01A-11D-2012-08	8273569	8478907	126527609	135	44015											
PAMR1	25891	broad.mit.edu	37	chr11	35456112	35456112	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catcatcccggtagaatttcCccaaaacaactttcaggtct	12	11	5	13	1	3	1	2	0	1	1	5	1	5	1	3	2	2	1	3	2	5	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:35456112C>T	uc001mwg.2	-	10	1617	c.1574G>A	c.(1573-1575)GGG>GAG	p.G525E	PAMR1_uc001mwf.2_Missense_Mutation_p.G542E|PAMR1_uc010rew.1_Missense_Mutation_p.G414E|PAMR1_uc010rex.1_Missense_Mutation_p.G485E	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	525	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						GTAGAATTTCCCCAAAACAAC	0.537													23	107					0	0	0	0	T	35456112	T	T	35456112	3	4	240	1	0	0	0	0	1	0	0	0	11467	623	22	4	596	4	PAMR1	11	35456112	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	26977205	35456112	99550404	136	44016											
F2	2147	broad.mit.edu	37	chr11	46747651	46747651	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctgccgcaacccagacgggGatgaggagggcgtgtggtgc	7	6	18	10	3	1	2	0	1	1	1	1	4	1	4	2	5	3	1	2	5	1	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:46747651G>A	uc001ndf.3	+	7	845	c.802G>A	c.(802-804)GAT>AAT	p.D268N	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	268	Kringle 2.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	CCCAGACGGGGATGAGGAGGG	0.632													21	121					0	0	0	0	A	46747651	A	A	46747651	3	1	240	1	0	0	0	0	1	0	0	0	5367	1174	41	2	828	2	F2	11	46747651	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	11291539	46747651	88258865	137	44017											
OR5L2	26338	broad.mit.edu	37	chr11	55594959	55594959	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggctaatatctttaacaagGacaaagccatctccttccta	13	12	5	11	0	2	0	0	0	2	0	4	1	3	1	3	2	2	1	3	2	6	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:55594959G>A	uc001nhy.1	+	1	265	c.265G>A	c.(265-267)GAC>AAC	p.D89N		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CTTTAACAAGGACAAAGCCAT	0.473										HNSCC(27;0.073)			53	68					0	0	0	0	A	55594959	A	A	55594959	3	1	240	1	0	0	0	0	1	0	0	0	11225	1174	41	2	267	2	OR5L2	11	55594959	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	8847308	55594959	79411557	138	44018											
OR5M8	219484	broad.mit.edu	37	chr11	56258161	56258161	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttttgcctgccctctgtaGagcgaatctttaaaatagca	10	14	7	10	1	2	1	0	0	2	1	2	2	2	1	2	0	4	2	2	0	5	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:56258161G>C	uc001nix.1	-	1	686	c.686C>G	c.(685-687)TCT>TGT	p.S229C		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					GCCCTCTGTAGAGCGAATCTT	0.413													8	47					0	0	0	0	C	56258161	C	C	56258161	3	2	240	1	0	0	0	0	1	0	0	0	11230	942	33	2	253	2	OR5M8	11	56258161	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	663202	56258161	78748355	139	44019											
OR5M11	219487	broad.mit.edu	37	chr11	56309925	56309925	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaagacagctattattttaGattcctcaacagtcttatct	14	15	4	8	0	3	2	1	0	2	2	4	2	4	2	1	0	2	1	1	0	7	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:56309925G>T	uc010rjl.1	-	1	809	c.809C>A	c.(808-810)TCT>TAT	p.S270Y		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TATTATTTTAGATTCCTCAAC	0.408													23	69					9.95505e-16	3.53877e-15	1	0	T	56309925	T	T	56309925	3	4	240	1	0	0	0	0	1	0	0	0	11228	942	33	2	111	2	OR5M11	11	56309925	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	51764	56309925	78696591	140	44020											
PRG3	10394	broad.mit.edu	37	chr11	57145249	57145249	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccattcccaggttgccctgGggaccagtaagcaaaattcc	10	8	9	14	0	0	0	0	0	0	0	2	1	2	1	5	3	2	3	5	3	3	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:57145249G>A	uc001njv.1	-	5	678	c.568C>T	c.(568-570)CCA>TCA	p.P190S		NM_006093	NP_006084	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3 precursor	190	C-type lectin.				basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding				0						GGTTGCCCTGGGGACCAGTAA	0.557													12	34					0	0	0	0	A	57145249	A	A	57145249	3	1	240	1	0	0	0	0	1	0	0	0	12542	1232	43	4	117	4	PRG3	11	57145249	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	835324	57145249	77861267	141	44021											
DDB1	1642	broad.mit.edu	37	chr11	61084032	61084032	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttagggtcagaccgcagtggCcataatcctggaacaaggac	12	7	12	10	1	1	1	1	0	0	1	2	3	2	3	3	4	1	1	3	4	4	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:61084032C>T	uc001nrc.3	-	11	1459	c.1233G>A	c.(1231-1233)TGG>TGA	p.W411*	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Nonsense_Mutation_p.W411*|DDB1_uc010rlg.1_RNA|DDB1_uc001nrd.2_Nonsense_Mutation_p.W411*	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	411	Interaction with CDT1.|Interaction with CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						ACCGCAGTGGCCATAATCCTG	0.458								NER					29	104					0	0	0	0	T	61084032	T	T	61084032	4	4	240	1	0	0	0	0	0	1	0	0	4340	740	26	4	2257	4	DDB1	11	61084032	Nonsense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	3938783	61084032	73922484	142	44022											
FADS2	9415	broad.mit.edu	37	chr11	61632693	61632693	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgaagtctctatgtgccaaGcatggcattgaataccagga	12	10	11	8	0	1	2	0	2	1	0	2	3	1	3	2	2	3	2	2	2	5	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:61632693G>T	uc001nsl.1	+	11	1377	c.1227G>T	c.(1225-1227)AAG>AAT	p.K409N	FADS2_uc001nsj.2_Missense_Mutation_p.K387N|FADS2_uc010rlo.1_Missense_Mutation_p.K378N	NM_004265	NP_004256	O95864	FADS2_HUMAN	fatty acid desaturase 2	409	Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			ovary(1)|pancreas(1)	2					Alpha-Linolenic Acid(DB00132)	TATGTGCCAAGCATGGCATTG	0.612													18	55					4.75885e-15	1.67939e-14	1	0	T	61632693	T	T	61632693	3	4	240	1	0	0	0	0	1	0	0	0	5394	962	34	4	1269	4	FADS2	11	61632693	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	548661	61632693	73373823	143	44023											
KAT5	10524	broad.mit.edu	37	chr11	65484420	65484420	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taaccctgcctccctaccagCgccggggctacggcaagctg	7	6	11	17	3	0	0	0	0	0	0	1	0	1	0	5	3	6	3	5	3	4	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:65484420C>T	uc001ofi.2	+	11	1382	c.1132C>T	c.(1132-1134)CGC>TGC	p.R378C	KAT5_uc001ofj.2_Missense_Mutation_p.R326C|KAT5_uc001ofk.2_Missense_Mutation_p.R411C|KAT5_uc010roo.1_Missense_Mutation_p.R359C|KAT5_uc001ofl.2_Missense_Mutation_p.R167C	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	378	Acetyl-CoA binding.				androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						TCCCTACCAGCGCCGGGGCTA	0.592													28	85					0	0	0	0	T	65484420	T	T	65484420	3	4	240	1	0	0	0	0	1	0	0	0	8022	768	27	1	1269	1	KAT5	11	65484420	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	3851727	65484420	69522096	144	44024											
CATSPER1	117144	broad.mit.edu	37	chr11	65788061	65788061	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagatgaagtactggatgatGatgtaaattacgaggatggg	15	10	14	2	1	0	4	0	3	0	1	0	7	0	6	0	3	2	2	0	3	6	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:65788061G>A	uc001ogt.2	-	7	2103	c.1965C>T	c.(1963-1965)ATC>ATT	p.I655I		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	655	Helical; Name=Segment S6; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						ACTGGATGATGATGTAAATTA	0.597													9	39					0	0	0	0	A	65788061	A	A	65788061	2	1	240	1	0	0	0	0	0	0	0	1	2699	1280	45	2		2	CATSPER1	11	65788061	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	303641	65788061	69218455	145	44025											
FAM86C	55199	broad.mit.edu	37	chr11	71500886	71500886	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctgctgcgggatattttgCagaaggtaagaattccagag	12	10	13	6	1	0	3	0	0	0	3	1	4	1	4	1	2	4	4	1	2	4	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:71500886C>A	uc001oqv.3	+	2	180	c.154C>A	c.(154-156)CAG>AAG	p.Q52K	FAM86C_uc009ysr.2_Missense_Mutation_p.Q52K|FAM86C_uc001oqw.3_Missense_Mutation_p.Q52K|FAM86C_uc009yss.2_RNA|FAM86C_uc010rqq.1_RNA	NM_018172	NP_060642	Q9NVL1	FA86C_HUMAN	hypothetical protein LOC55199 isoform 1	52											0						GGATATTTTGCAGAAGGTAAG	0.483													20	72					6.44725e-10	2.22682e-09	1	0	A	71500886	A	A	71500886	3	1	240	1	0	0	0	0	1	0	0	0	5678	711	25	4	160	4	FAM86C	11	71500886	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	5712825	71500886	63505630	146	44026											
C11orf87	399947	broad.mit.edu	37	chr11	109294892	109294892	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtccccaaggagcacacgCagcttcctcctgtttggaca	9	8	9	15	1	0	0	0	0	0	0	3	2	3	2	4	2	2	4	4	2	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:109294892C>A	uc001pkn.2	+	2	907	c.533C>A	c.(532-534)GCA>GAA	p.A178E	C11orf87_uc010rwb.1_RNA	NM_207645	NP_997528	Q6NUJ2	CK087_HUMAN	hypothetical protein LOC399947 precursor	178	Cytoplasmic (Potential).					integral to membrane				ovary(2)	2						GGAGCACACGCAGCTTCCTCC	0.637													21	34					4.35082e-09	1.48691e-08	1	0	A	109294892	A	A	109294892	3	1	240	1	0	0	0	0	1	0	0	0	1675	710	25	4	535	4	C11orf87	11	109294892	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	37794006	109294892	25711624	147	44027											
APLP2	334	broad.mit.edu	37	chr11	130000002	130000002	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatcgcttacataccatcCgtcattaccagcatgtgttg	11	12	7	11	2	1	1	1	0	0	1	3	1	2	1	3	0	4	3	3	0	4	4	rs149975560		TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr11:130000002C>T	uc010sby.1	+	11	1682	c.1525C>T	c.(1525-1527)CGT>TGT	p.R509C	APLP2_uc001qfp.2_Missense_Mutation_p.R509C|APLP2_uc001qfq.2_Missense_Mutation_p.R453C|APLP2_uc010sbz.1_Missense_Mutation_p.R297C|APLP2_uc001qfr.2_Missense_Mutation_p.R275C|APLP2_uc001qfs.2_Missense_Mutation_p.R280C|APLP2_uc001qfv.2_Missense_Mutation_p.R400C	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	509	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		ACATACCATCCGTCATTACCA	0.478													24	113					0	0	0	0	T	130000002	T	T	130000002	3	4	240	1	0	0	0	0	1	0	0	0	779	652	23	1	1567	1	APLP2	11	130000002	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	20705110	130000002	5006514	148	44028											
A2ML1	144568	broad.mit.edu	37	chr12	9021141	9021141	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcctgctctcagttatgtggGgagccgtagctcttccaata	7	13	10	11	1	2	0	1	0	2	0	5	1	4	1	3	2	3	4	3	2	4	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:9021141G>A	uc001quz.3	+	32	4168	c.4070G>A	c.(4069-4071)GGG>GAG	p.G1357E	A2ML1_uc001qva.1_Missense_Mutation_p.G937E|A2ML1_uc010sgm.1_Missense_Mutation_p.G857E|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1201						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						AGTTATGTGGGGAGCCGTAGC	0.388													40	97					0	0	0	0	A	9021141	A	A	9021141	3	1	240	1	0	0	0	0	1	0	0	0	5	1232	43	4	4196	4	A2ML1	12	9021141	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08		9021141	124830754	149	44029											
PRB3	5544	broad.mit.edu	37	chr12	11422583	11422583	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagggccagcagggccacCgacagcagaatcagtagcat	12	4	12	13	1	2	1	2	0	0	1	2	2	2	1	3	2	3	4	3	2	2	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:11422583C>T	uc001qzs.2	-	1	59	c.21G>A	c.(19-21)TCG>TCA	p.S7S	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	7						extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GCAGGGCCACCGACAGCAGAA	0.532													18	69					0	0	0	0	T	11422583	T	T	11422583	2	4	240	1	0	0	0	0	0	0	0	1	12506	639	23	1		1	PRB3	12	11422583	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	2401442	11422583	122429312	150	44030											
LRP6	4040	broad.mit.edu	37	chr12	12318022	12318022	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagttactcaccaatcactcGatgaacatttgtagccttta	12	13	6	10	1	2	1	2	1	0	0	3	3	2	1	2	0	3	2	2	0	5	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:12318022G>A	uc001rah.3	-	8	1895	c.1753C>T	c.(1753-1755)CGA>TGA	p.R585*	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Nonsense_Mutation_p.R585*	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	585	Extracellular (Potential).|Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CCAATCACTCGATGAACATTT	0.423													31	91					0	0	0	0	A	12318022	A	A	12318022	4	1	240	1	0	0	0	0	0	1	0	0	9012	1066	37	1	3152	1	LRP6	12	12318022	Nonsense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	895439	12318022	121533873	151	44031											
DENND5B	160518	broad.mit.edu	37	chr12	31605306	31605306	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatcccaaattgaacaagAacctcagagagttcttggat	14	9	10	8	0	2	3	1	1	1	2	3	6	3	5	2	2	2	1	2	2	4	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:31605306A>T	uc001rki.1	-	5	1383	c.1197T>A	c.(1195-1197)GTT>GTA	p.V399V	DENND5B_uc001rkh.1_Silent_p.V434V|DENND5B_uc009zjq.1_Silent_p.V318V|DENND5B_uc001rkj.2_Silent_p.V421V|DENND5B_uc001rkk.1_Silent_p.V321V	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	399						integral to membrane				ovary(1)|central_nervous_system(1)	2						ATTGAACAAGAACCTCAGAGA	0.403													17	66					0	0	0	0	T	31605306	T	T	31605306	2	4	240	1	0	0	0	0	0	0	0	1	4459	233	9	5		5	DENND5B	12	31605306	Silent	SNP	A	TCGA-CV-7252-01A-11D-2012-08	19287284	31605306	102246589	152	44032											
ADAMTS20	80070	broad.mit.edu	37	chr12	43777495	43777495	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttatctgtgcactccattcGttgatgtgaatcttttctct	6	19	7	9	1	3	2	0	2	3	0	6	2	4	2	1	0	1	3	1	0	2	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:43777495G>A	uc010skx.1	-	31	4663	c.4663C>T	c.(4663-4665)CGA>TGA	p.R1555*		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1555	TSP type-1 13.					proteinaceous extracellular matrix	zinc ion binding	p.R1555*(1)		central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CACTCCATTCGTTGATGTGAA	0.343													8	55					0	0	0	0	A	43777495	A	A	43777495	4	1	240	1	0	0	0	0	0	1	0	0	266	1153	40	1	1104	1	ADAMTS20	12	43777495	Nonsense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	12172189	43777495	90074400	153	44033											
ARID2	196528	broad.mit.edu	37	chr12	46123891	46123892	+	Frame_Shift_Del	DEL	AG	-	-																															atcttcacggtctctacaccAgagtcactactttaggcgga																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:46123891_46123892delAG	uc001ros.1	+	2	157_158	c.157_158delAG	c.(157-159)AGAfs	p.R53fs	ARID2_uc001ror.2_Frame_Shift_Del_p.R53fs|LOC400027_uc001roq.2_5'Flank	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	53	ARID.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCTCTACACCAGAGTCACTACT	0.53													---	---	---								-	46123892	-	-	46123891	7	5	240	1	0	1	0	1	0	0	0	0	915	180	7	0	163	0	ARID2	12	46123891	Frame_Shift_Del	DEL	AG	TCGA-CV-7252-01A-11D-2012-08	2346396	46123891	87728004	154	44034											
ARID2	196528	broad.mit.edu	37	chr12	46245639	46245639	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtgataaaataatttgcCaaaaggaggaggaagcaaag	20	6	12	3	0	0	1	0	1	0	0	0	4	0	4	1	4	2	1	1	4	8	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:46245639C>T	uc001ros.1	+	15	3733	c.3733C>T	c.(3733-3735)CAA>TAA	p.Q1245*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q1245*|ARID2_uc009zkg.1_Nonsense_Mutation_p.Q701*|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q872*|ARID2_uc001rou.1_Nonsense_Mutation_p.Q579*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1245					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AATAATTTGCCAAAAGGAGGA	0.458													14	57					0	0	0	0	T	46245639	T	T	46245639	4	4	240	1	0	0	0	0	0	1	0	0	915	595	21	4	3791	4	ARID2	12	46245639	Nonsense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	121748	46245639	87606256	155	44035											
MLL2	8085	broad.mit.edu	37	chr12	49420049	49420049	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccggccgcccgttgttctCaccaatagaacagcgatagc	9	8	9	15	4	1	1	1	0	1	1	3	2	2	1	4	1	3	2	4	1	4	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:49420049C>T	uc001rta.3	-	48	15700	c.15700G>A	c.(15700-15702)GAG>AAG	p.E5234K		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5234	FYR N-terminal.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCGTTGTTCTCACCAATAGAA	0.597			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			25	65					0	0	0	0	T	49420049	T	T	49420049	3	4	240	1	0	0	0	0	1	0	0	0	9674	835	29	2	941	2	MLL2	12	49420049	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	3174410	49420049	84431846	156	44036											
MLL2	8085	broad.mit.edu	37	chr12	49420671	49420672	+	Frame_Shift_Ins	INS	-	GGTA	GGTA																															agcagcgacgcatgtctcgcINSggtaccttgtcaggtcgcaa																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:49420671_49420672insGGTA	uc001rta.3	-	48	15077_15078	c.15077_15078insTACC	c.(15076-15078)CCGfs	p.P5026fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5026					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCATGTCTCGCGGTACCTTGTC	0.624			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								GGTA	49420672	GGTA	GGTA	49420671	7	5	240	1	0	1	1	0	0	0	0	0	9674	755	27	0	1563	0	MLL2	12	49420671	Frame_Shift_Ins	INS	-	TCGA-CV-7252-01A-11D-2012-08	622	49420671	84431224	157	44037											
ACVR1B	91	broad.mit.edu	37	chr12	52369156	52369156	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgggatggagcaccatgtgCgcacctgcatccccaaagtg	10	7	12	12	1	0	0	0	0	0	0	1	2	1	2	4	2	3	3	4	2	1	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:52369156C>T	uc001rzn.2	+	2	241	c.199C>T	c.(199-201)CGC>TGC	p.R67C	ACVR1B_uc001rzl.2_Missense_Mutation_p.R67C|ACVR1B_uc001rzm.2_Missense_Mutation_p.R67C|ACVR1B_uc010snn.1_Missense_Mutation_p.R67C	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	67	Extracellular (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	GCACCATGTGCGCACCTGCAT	0.592													18	46					0	0	0	0	T	52369156	T	T	52369156	3	4	240	1	0	0	0	0	1	0	0	0	221	768	27	1	205	1	ACVR1B	12	52369156	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	2948485	52369156	81482739	158	44038											
HOXC11	3227	broad.mit.edu	37	chr12	54367367	54367367	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaccgtcaccgagatcctCatgaaaaacgaaggctccta	13	7	7	14	3	2	2	2	1	0	1	5	4	5	2	5	1	1	1	5	1	4	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:54367367C>A	uc001sem.2	+	1	458	c.342C>A	c.(340-342)CTC>CTA	p.L114L		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	114					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCGAGATCCTCATGAAAAACG	0.637			T	NUP98	AML								54	193					2.47907e-22	8.97625e-22	1	0	A	54367367	A	A	54367367	2	1	240	1	0	0	0	0	0	0	0	1	7349	813	29	2		2	HOXC11	12	54367367	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1998211	54367367	79484528	159	44039											
KIAA0748	9840	broad.mit.edu	37	chr12	55356756	55356756	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caacttggtccaaactgttcCttttgggggtgttgtggggt	5	15	14	7	0	0	0	0	0	0	0	2	0	2	0	2	5	2	2	2	5	2	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:55356756C>T	uc001sgn.3	-	9	1036	c.926G>A	c.(925-927)AGG>AAG	p.R309K	KIAA0748_uc001sgl.3_Missense_Mutation_p.R171K|KIAA0748_uc001sgm.3_Missense_Mutation_p.R56K|KIAA0748_uc010spb.1_Missense_Mutation_p.R56K|KIAA0748_uc010spc.1_Missense_Mutation_p.R171K|KIAA0748_uc010spd.1_Missense_Mutation_p.R309K|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	309										ovary(1)|central_nervous_system(1)	2						CAAACTGTTCCTTTTGGGGGT	0.532													15	46					0	0	0	0	T	55356756	T	T	55356756	3	4	240	1	0	0	0	0	1	0	0	0	8229	681	24	4	647	4	KIAA0748	12	55356756	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	989389	55356756	78495139	160	44040											
DPY19L2	283417	broad.mit.edu	37	chr12	63964555	63964555	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacctcaagtctgcatcttcGtaatgtggatgattcacaat	12	13	7	9	1	4	1	2	1	2	0	5	2	4	2	1	1	2	2	1	1	4	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:63964555G>T	uc001srp.1	-	20	2164	c.1983C>A	c.(1981-1983)TAC>TAA	p.Y661*	DPY19L2_uc010sso.1_Nonsense_Mutation_p.Y108*	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	661					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		CTGCATCTTCGTAATGTGGAT	0.388													18	89					1.33834e-09	4.60615e-09	1	0	T	63964555	T	T	63964555	4	4	240	1	0	0	0	0	0	1	0	0	4763	1140	40	3	305	3	DPY19L2	12	63964555	Nonsense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	8607799	63964555	69887340	161	44041											
ZFC3H1	196441	broad.mit.edu	37	chr12	72005625	72005625	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacatcttggcttgaagtttCagaatctgaacattgctttc	11	15	7	8	0	3	3	1	2	2	1	4	3	3	3	0	1	3	3	0	1	4	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:72005625C>G	uc001swo.2	-	32	6029	c.5670G>C	c.(5668-5670)CTG>CTC	p.L1890L		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1890					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						CTTGAAGTTTCAGAATCTGAA	0.363													12	45					0	0	0	0	G	72005625	G	G	72005625	2	3	240	1	0	0	0	0	0	0	0	1	17700	813	29	2		2	ZFC3H1	12	72005625	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	8041070	72005625	61846270	162	44042											
ALX1	8092	broad.mit.edu	37	chr12	85695240	85695240	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagcacaccgccaatatttCatgggccatgtaacatacag	13	8	9	11	1	1	0	1	0	0	0	1	1	1	1	3	2	3	2	3	2	4	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:85695240C>T	uc001tae.3	+	4	972	c.968C>T	c.(967-969)TCA>TTA	p.S323L		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	323					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		GCCAATATTTCATGGGCCATG	0.368													16	50					0	0	0	0	T	85695240	T	T	85695240	3	4	240	1	0	0	0	0	1	0	0	0	556	838	29	2	982	2	ALX1	12	85695240	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	13689615	85695240	48156655	163	44043											
ANKRD13A	88455	broad.mit.edu	37	chr12	110474131	110474131	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctatgacgcccagtatgaGaggtgattgactgacgtgac	11	9	12	9	2	0	6	0	6	0	1	0	7	0	6	2	1	0	1	2	1	2	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:110474131G>C	uc001tpx.2	+	14	1834	c.1575G>C	c.(1573-1575)GAG>GAC	p.E525D	ANKRD13A_uc010sxw.1_Missense_Mutation_p.E524D|ANKRD13A_uc001tpy.2_Missense_Mutation_p.E125D|ANKRD13A_uc001tpz.2_Missense_Mutation_p.E163D|ANKRD13A_uc001tqa.2_3'UTR	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13	525	UIM 1.										0						CCCAGTATGAGAGGTGATTGA	0.517													28	105					0	0	0	0	C	110474131	C	C	110474131	3	2	240	1	0	0	0	0	1	0	0	0	641	933	33	2	1629	2	ANKRD13A	12	110474131	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	24778891	110474131	23377764	164	44044											
KDM2B	84678	broad.mit.edu	37	chr12	121947475	121947475	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagagctttcaggcccttCagttcaaactcagtgagatg	11	10	9	11	0	4	2	4	1	0	2	4	3	4	2	2	1	2	2	2	1	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:121947475C>T	uc001uat.2	-	11	1646	c.1542G>A	c.(1540-1542)CTG>CTA	p.L514L	KDM2B_uc001uar.2_Silent_p.L105L|KDM2B_uc001uas.2_Silent_p.L483L|KDM2B_uc001uau.2_Silent_p.L397L|KDM2B_uc001uav.3_Silent_p.L424L	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	514					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						TCAGGCCCTTCAGTTCAAACT	0.597													16	59					0	0	0	0	T	121947475	T	T	121947475	2	4	240	1	0	0	0	0	0	0	0	1	8164	813	29	2		2	KDM2B	12	121947475	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	11473344	121947475	11904420	165	44045											
MMP17	4326	broad.mit.edu	37	chr12	132326314	132326314	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcgctacgggctcccctaCgaggacaaggtgcgcgtctg	6	7	14	14	5	1	0	0	0	1	0	2	2	2	1	2	3	4	2	2	3	3	2	rs73162905	byFrequency	TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:132326314C>T	uc001ujc.1	+	5	951	c.852C>T	c.(850-852)TAC>TAT	p.Y284Y	MMP17_uc001ujd.1_Silent_p.Y200Y	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	284					proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		GGCTCCCCTACGAGGACAAGG	0.662													8	14					0	0	0	0	T	132326314	T	T	132326314	2	4	240	1	0	0	0	0	0	0	0	1	9709	547	19	1		1	MMP17	12	132326314	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	10378839	132326314	1525581	166	44046											
ULK1	8408	broad.mit.edu	37	chr12	132401500	132401500	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctgcacactcccacaggtCtttcagcaccagccgcctca	8	7	6	20	1	3	0	2	0	1	0	4	0	4	0	5	1	3	2	5	1	0	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr12:132401500C>T	uc001uje.2	+	21	2343	c.2075C>T	c.(2074-2076)TCT>TTT	p.S692F		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	692					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TCCCACAGGTCTTTCAGCACC	0.657													5	44					0	0	0	0	T	132401500	T	T	132401500	3	4	240	1	0	0	0	0	1	0	0	0	17043	913	32	2	2157	2	ULK1	12	132401500	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	75186	132401500	1450395	167	44047											
KCTD4	386618	broad.mit.edu	37	chr13	45768657	45768657	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccaggctgttgtgtttccCttcatactccttttcttttt	3	22	5	11	0	2	0	1	0	1	0	5	0	5	0	3	1	1	3	3	1	1	9			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr13:45768657C>T	uc001uzx.3	-	2	450	c.46G>A	c.(46-48)GGG>AGG	p.G16R	GTF2F2_uc001uzv.2_Intron|GTF2F2_uc001uzw.2_Intron	NM_198404	NP_940686	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerisation domain	16						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)		TTGTGTTTCCCTTCATACTCC	0.353													40	121					0	0	0	0	T	45768657	T	T	45768657	3	4	240	1	0	0	0	0	1	0	0	0	8150	681	24	4	737	4	KCTD4	13	45768657	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08		45768657	69401221	168	44048											
CPB2	1361	broad.mit.edu	37	chr13	46632457	46632457	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactgccttcacttctggttCtgactcaggataaagtccac	9	12	7	13	0	4	1	2	1	2	0	5	2	5	2	2	2	1	1	2	2	2	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr13:46632457C>G	uc001vaw.2	-	9	923	c.856G>C	c.(856-858)GAA>CAA	p.E286Q	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Missense_Mutation_p.E249Q	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	286					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		ACTTCTGGTTCTGACTCAGGA	0.428													16	91					0	0	0	0	G	46632457	G	G	46632457	3	3	240	1	0	0	0	0	1	0	0	0	3812	922	32	2	427	2	CPB2	13	46632457	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	863800	46632457	68537421	169	44049											
CLDN10	9071	broad.mit.edu	37	chr13	96205036	96205036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacggcttcggagatcatcgCcttcatggtctccatctcag	7	11	9	14	3	4	1	3	0	2	1	8	2	4	1	2	3	0	1	2	3	0	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr13:96205036C>T	uc001vmh.2	+	1	90	c.29C>T	c.(28-30)GCC>GTC	p.A10V	CLDN10_uc001vmg.2_Intron|CLDN10_uc010tii.1_Intron	NM_006984	NP_008915	P78369	CLD10_HUMAN	claudin 10 isoform b	10	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			GAGATCATCGCCTTCATGGTC	0.672													13	18					0	0	0	0	T	96205036	T	T	96205036	3	4	240	1	0	0	0	0	1	0	0	0	3487	739	26	4	249	4	CLDN10	13	96205036	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	49572579	96205036	18964842	170	44050											
ARGLU1	55082	broad.mit.edu	37	chr13	107219952	107219953	+	In_Frame_Ins	INS	-	CTC	CTC																															cgctcgaactccgctttcttINSctcctcctcctctcgcttct																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr13:107219952_107219953insCTC	uc001vqk.3	-	1	562_563	c.315_316insGAG	c.(313-318)insGAG	p.105_106insE		NM_018011	NP_060481	Q9NWB6	ARGL1_HUMAN	arginine and glutamate rich 1	105_106	Glu-rich.										0	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					TCCGCTTTCTTCTCCTCCTCCT	0.46													---	---	---								CTC	107219953	CTC	CTC	107219952	7	5	240	1	0	1	1	0	0	0	0	0	860	1792	62	0	521	0	ARGLU1	13	107219952	In_Frame_Ins	INS	-	TCGA-CV-7252-01A-11D-2012-08	11014916	107219952	7949926	171	44051											
PCK2	5106	broad.mit.edu	37	chr14	24566131	24566131	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgggctgagccccttgggCtggccatcatgccgtagcat	6	9	13	13	1	1	1	1	1	0	0	1	1	1	1	4	3	3	4	4	3	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr14:24566131C>A	uc001wlt.2	+	2	192	c.60C>A	c.(58-60)GGC>GGA	p.G20G	NRL_uc001wlp.2_5'Flank|NRL_uc001wlq.2_Intron|PCK2_uc001wlr.1_Silent_p.G32G|PCK2_uc001wls.2_Silent_p.G20G|PCK2_uc010tnw.1_Intron|PCK2_uc010ald.2_Translation_Start_Site|PCK2_uc010ale.2_Translation_Start_Site|PCK2_uc010tnx.1_Translation_Start_Site|PCK2_uc001wlu.3_Translation_Start_Site	NM_004563	NP_004554	Q16822	PCKGM_HUMAN	mitochondrial phosphoenolpyruvate carboxykinase	20					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0184)		GCCCCTTGGGCTGGCCATCAT	0.567													28	115					2.79863e-10	9.7006e-10	1	0	A	24566131	A	A	24566131	2	1	240	1	0	0	0	0	0	0	0	1	11636	784	28	4		4	PCK2	14	24566131	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08		24566131	82783409	172	44052											
NFATC4	4776	broad.mit.edu	37	chr14	24845916	24845916	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catccccaccgcttgaaggcCccttcccttcccagagtgat	7	9	7	18	1	0	3	0	2	0	1	3	3	3	3	7	1	0	1	7	1	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr14:24845916C>T	uc001wpc.2	+	9	2794	c.2473C>T	c.(2473-2475)CCC>TCC	p.P825S	NFATC4_uc010tok.1_Missense_Mutation_p.P888S|NFATC4_uc010tol.1_Missense_Mutation_p.P888S|NFATC4_uc010alr.2_Intron|NFATC4_uc010tom.1_Missense_Mutation_p.P838S|NFATC4_uc010ton.1_Missense_Mutation_p.P838S|NFATC4_uc010too.1_Intron|NFATC4_uc010alt.2_Missense_Mutation_p.P857S|NFATC4_uc010top.1_Missense_Mutation_p.P857S|NFATC4_uc010toq.1_Intron|NFATC4_uc010tor.1_Intron|NFATC4_uc010tos.1_Missense_Mutation_p.P755S|NFATC4_uc010tot.1_Missense_Mutation_p.P813S|NFATC4_uc010tou.1_Missense_Mutation_p.P755S|NFATC4_uc010tov.1_Intron|NFATC4_uc010tow.1_Intron|NFATC4_uc010alv.2_Missense_Mutation_p.P813S|NFATC4_uc010tox.1_Missense_Mutation_p.P755S|NFATC4_uc001wpd.2_Missense_Mutation_p.P360S|NFATC4_uc010toy.1_Intron|NFATC4_uc010toz.1_Missense_Mutation_p.P360S|NFATC4_uc010tpa.1_Missense_Mutation_p.P113S|NFATC4_uc010tpb.1_Missense_Mutation_p.P113S	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	825	Pro-rich.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		GCTTGAAGGCCCCTTCCCTTC	0.642													40	181					0	0	0	0	T	24845916	T	T	24845916	3	4	240	1	0	0	0	0	1	0	0	0	10419	623	22	4	2700	4	NFATC4	14	24845916	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	279785	24845916	82503624	173	44053											
NFKBIA	4792	broad.mit.edu	37	chr14	35872923	35872923	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggttgttctggaagttgagGaaggccaggtctcccttcac	8	11	13	9	0	3	1	1	1	2	0	4	3	3	3	2	5	0	3	2	5	2	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr14:35872923G>A	uc001wtf.3	-	2	419	c.309C>T	c.(307-309)TTC>TTT	p.F103F	NFKBIA_uc001wte.3_Silent_p.F13F|NFKBIA_uc001wtg.3_Silent_p.F103F|NFKBIA_uc010amo.2_Intron	NM_020529	NP_065390	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene	103	ANK 1.				anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(2)	2	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		GGAAGTTGAGGAAGGCCAGGT	0.582													6	28					0	0	0	0	A	35872923	A	A	35872923	2	1	240	1	0	0	0	0	0	0	0	1	10431	1165	41	2		2	NFKBIA	14	35872923	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	11027007	35872923	71476617	174	44054											
FSCB	84075	broad.mit.edu	37	chr14	44975031	44975031	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgggagccttttgtgctgagGgagaccgaatttcaccaaga	10	10	13	8	1	1	3	1	1	0	2	1	6	1	4	3	2	2	1	3	2	2	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr14:44975031G>A	uc001wvn.2	-	1	1469	c.1160C>T	c.(1159-1161)CCC>CTC	p.P387L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	387	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TTGTGCTGAGGGAGACCGAAT	0.527													33	111					0	0	0	0	A	44975031	A	A	44975031	3	1	240	1	0	0	0	0	1	0	0	0	6100	1232	43	4	1321	4	FSCB	14	44975031	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	9102108	44975031	62374509	175	44055											
SLC8A3	6547	broad.mit.edu	37	chr14	70634140	70634140	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attggccatctccaccagctGatctaagtccttctctgggt	7	13	8	13	0	3	1	0	1	3	0	6	1	4	1	4	2	1	1	4	2	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr14:70634140G>A	uc001xly.2	-	2	1754	c.1000C>T	c.(1000-1002)CAG>TAG	p.Q334*	SLC8A3_uc001xlw.2_Nonsense_Mutation_p.Q334*|SLC8A3_uc001xlx.2_Nonsense_Mutation_p.Q334*|SLC8A3_uc001xlz.2_Nonsense_Mutation_p.Q334*|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	334	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCCACCAGCTGATCTAAGTCC	0.522													25	61					0	0	0	0	A	70634140	A	A	70634140	4	1	240	1	0	0	0	0	0	1	0	0	14772	1299	45	2	1922	2	SLC8A3	14	70634140	Nonsense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	25659109	70634140	36715400	176	44056											
SERPINA4	5267	broad.mit.edu	37	chr14	95035800	95035800	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagcagccaccagcttcgcGatcaaattcttctctgccca	9	9	7	16	2	3	0	1	0	2	0	5	1	3	0	3	0	4	3	3	0	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr14:95035800G>A	uc001ydk.2	+	5	1218	c.1152G>A	c.(1150-1152)GCG>GCA	p.A384A	SERPINA4_uc010avd.2_Silent_p.A421A|SERPINA4_uc001ydl.2_Silent_p.A384A	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	384					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		CCAGCTTCGCGATCAAATTCT	0.547													24	52					0	0	0	0	A	95035800	A	A	95035800	2	1	240	1	0	0	0	0	0	0	0	1	14156	1045	37	1		1	SERPINA4	14	95035800	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	24401660	95035800	12313740	177	44057											
KLC1	3831	broad.mit.edu	37	chr14	104142025	104142025	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaattatttcttataatttaGggaaagcaaaaggatgggac	17	12	9	3	0	1	0	0	0	1	0	1	3	1	3	0	3	1	1	0	3	8	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr14:104142025G>A	uc001yno.2	+	11	1620	c.1312_splice	c.e11-1	p.G438_splice	KLC1_uc010tyd.1_Splice_Site_p.G597_splice|KLC1_uc010tye.1_Splice_Site_p.G434_splice|KLC1_uc001ynm.1_Splice_Site_p.G438_splice|KLC1_uc001ynn.1_Splice_Site_p.G432_splice|KLC1_uc010tyf.1_Splice_Site_p.G438_splice|KLC1_uc001ynp.1_5'Flank|KLC1_uc001ynr.1_5'Flank|KLC1_uc010awu.1_5'Flank|KLC1_uc001ynq.1_5'Flank|KLC1_uc001yns.2_5'Flank	NM_182923	NP_891553	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 2						blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				TTATAATTTAGGGAAAGCAAA	0.328													9	39					0	0	0	0	A	104142025	A	A	104142025	5	1	240	1	0	0	0	0	0	0	1	0	8372	1014	35	4	1349	4	KLC1	14	104142025	Splice_Site	SNP	G	TCGA-CV-7252-01A-11D-2012-08	9106225	104142025	3207515	178	44058											
PACS2	23241	broad.mit.edu	37	chr14	105843172	105843172	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaggacctggacctcctgtAtgacaccctggacatggagc	9	7	13	12	0	0	1	0	1	0	0	1	6	1	6	4	5	1	1	4	5	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr14:105843172A>T	uc001yqt.2	+	9	1044	c.869A>T	c.(868-870)TAT>TTT	p.Y290F	PACS2_uc001yqs.2_Missense_Mutation_p.Y215F|PACS2_uc001yqv.2_Missense_Mutation_p.Y290F|PACS2_uc001yqu.2_Missense_Mutation_p.Y290F	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	290					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GACCTCCTGTATGACACCCTG	0.667													23	38					0	0	0	0	T	105843172	T	T	105843172	3	4	240	1	0	0	0	0	1	0	0	0	11427	449	16	5	903	5	PACS2	14	105843172	Missense_Mutation	SNP	A	TCGA-CV-7252-01A-11D-2012-08	1701147	105843172	1506368	179	44059											
RYR3	6263	broad.mit.edu	37	chr15	34105687	34105687	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtggaacagcctttgaggtCcaagaaggccgtctggcaca	10	7	14	10	1	1	2	0	1	1	1	2	3	2	3	3	5	2	1	3	5	3	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:34105687C>T	uc001zhi.2	+	74	10479	c.10409C>T	c.(10408-10410)TCC>TTC	p.S3470F	RYR3_uc010bar.2_Missense_Mutation_p.S3465F	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3470					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCTTTGAGGTCCAAGAAGGCC	0.532													29	113					0	0	0	0	T	34105687	T	T	34105687	3	4	240	1	0	0	0	0	1	0	0	0	13835	855	30	2	10703	2	RYR3	15	34105687	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08		34105687	68425705	180	44060											
C15orf55	256646	broad.mit.edu	37	chr15	34649146	34649146	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccttgctcctttacaagaGagtcaggagtcttacacaac	13	10	7	11	0	2	1	1	0	1	1	3	3	3	2	2	1	5	1	2	1	5	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:34649146G>A	uc001zif.2	+	7	3008	c.2853G>A	c.(2851-2853)GAG>GAA	p.E951E	C15orf55_uc010ucc.1_Silent_p.E979E|C15orf55_uc010ucd.1_Silent_p.E969E	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	951						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CTTTACAAGAGAGTCAGGAGT	0.502			T	BRD3|BRD4	lethal midline carcinoma								9	56					0	0	0	0	A	34649146	A	A	34649146	2	1	240	1	0	0	0	0	0	0	0	1	1809	933	33	2		2	C15orf55	15	34649146	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	543459	34649146	67882246	181	44061											
ACTC1	70	broad.mit.edu	37	chr15	35082673	35082673	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcgtactcttgcttgctaatCcacatttgctggaaggtgga	8	14	10	9	1	1	0	0	0	1	0	3	2	2	2	1	3	4	4	1	3	3	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:35082673C>G	uc001ziu.1	-	7	1317	c.1074G>C	c.(1072-1074)TGG>TGC	p.W358C	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	358					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GCTTGCTAATCCACATTTGCT	0.502													41	91					0	0	0	0	G	35082673	G	G	35082673	3	3	240	1	0	0	0	0	1	0	0	0	195	856	30	2	63	2	ACTC1	15	35082673	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	433527	35082673	67448719	182	44062											
MAP1A	4130	broad.mit.edu	37	chr15	43819190	43819190	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactactccctcatggctggCtgacatcccaccctgggtgc	6	9	9	17	0	1	1	1	1	0	0	3	1	3	1	3	3	2	2	3	3	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:43819190C>A	uc001zrt.2	+	4	5986	c.5519C>A	c.(5518-5520)GCT>GAT	p.A1840D		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1840						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TCATGGCTGGCTGACATCCCA	0.612													21	56					1.87028e-06	6.25998e-06	1	0	A	43819190	A	A	43819190	3	1	240	1	0	0	0	0	1	0	0	0	9280	797	28	4	5521	4	MAP1A	15	43819190	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	8736517	43819190	58712202	183	44063											
CATSPER2	117155	broad.mit.edu	37	chr15	43927989	43927989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcccgacgcgccatctcctCattcagctctttcctgatat	6	13	5	17	3	4	1	2	1	2	0	7	2	6	1	4	0	1	1	4	0	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:43927989C>T	uc001zsh.2	-	9	1272	c.1057G>A	c.(1057-1059)GAG>AAG	p.E353K	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Missense_Mutation_p.E353K|CATSPER2_uc001zsj.2_Missense_Mutation_p.E353K	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	353	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GCCATCTCCTCATTCAGCTCT	0.502													16	43					0	0	0	0	T	43927989	T	T	43927989	3	4	240	1	0	0	0	0	1	0	0	0	2700	835	29	2	555	2	CATSPER2	15	43927989	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	108799	43927989	58603403	184	44064											
UNC13C	440279	broad.mit.edu	37	chr15	54306178	54306178	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgctattaaaattgaatttGctcagaggataggacaccag	15	11	9	6	0	1	2	1	1	0	1	1	4	1	4	1	2	2	2	1	2	5	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:54306178G>A	uc002ack.2	+	1	1078	c.1078G>A	c.(1078-1080)GCT>ACT	p.A360T		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	360					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AATTGAATTTGCTCAGAGGAT	0.378													12	31					0	0	0	0	A	54306178	A	A	54306178	3	1	240	1	0	0	0	0	1	0	0	0	17054	1319	46	4	1080	4	UNC13C	15	54306178	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	10378189	54306178	48225214	185	44065											
LARP6	55323	broad.mit.edu	37	chr15	71124454	71124454	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgttgtcaggacccctgggCaacctcagcacccctacggg	7	7	12	15	1	2	0	2	0	0	0	2	1	2	1	5	3	3	3	5	3	2	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:71124454C>A	uc002ass.2	-	3	1484	c.1413G>T	c.(1411-1413)TTG>TTT	p.L471F		NM_018357	NP_060827	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	471					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0						GACCCCTGGGCAACCTCAGCA	0.547													25	91					2.41591e-17	8.65109e-17	1	0	A	71124454	A	A	71124454	3	1	240	1	0	0	0	0	1	0	0	0	8672	709	25	4	66	4	LARP6	15	71124454	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	16818276	71124454	31406938	186	44066											
KIAA1199	57214	broad.mit.edu	37	chr15	81230170	81230170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtggggctctgctacccgcGaggcaccacattctccatcc	7	8	10	16	2	2	0	0	0	2	0	4	1	3	0	4	3	2	3	4	3	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:81230170G>A	uc002bfw.1	+	24	3517	c.3257G>A	c.(3256-3258)CGA>CAA	p.R1086Q	KIAA1199_uc010unn.1_Missense_Mutation_p.R1086Q	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	1086										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TGCTACCCGCGAGGCACCACA	0.572													37	91					0	0	0	0	A	81230170	A	A	81230170	3	1	240	1	0	0	0	0	1	0	0	0	8252	1058	37	1	3347	1	KIAA1199	15	81230170	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	10105716	81230170	21301222	187	44067											
TMC3	342125	broad.mit.edu	37	chr15	81648086	81648086	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtttttgcttttctttttCtcctgttcttccaatatagc	5	22	5	9	0	3	0	0	0	3	0	5	0	4	0	2	1	2	3	2	1	3	10			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:81648086C>G	uc002bgo.1	-	9	915	c.915G>C	c.(913-915)GAG>GAC	p.E305D	TMC3_uc010blr.1_RNA|TMC3_uc002bgp.2_Missense_Mutation_p.E305D	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	305	Extracellular (Potential).					integral to membrane				ovary(1)|liver(1)	2						TTTTCTTTTTCTCCTGTTCTT	0.284													14	44					0	0	0	0	G	81648086	G	G	81648086	3	3	240	1	0	0	0	0	1	0	0	0	16052	912	32	2	2443	2	TMC3	15	81648086	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	417916	81648086	20883306	188	44068											
ALDH1A3	220	broad.mit.edu	37	chr15	101447334	101447334	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aattaatcatagattttcggGccagtgcaaccaatactgaa	15	11	7	8	1	1	2	1	1	0	1	2	2	1	2	2	1	3	1	2	1	7	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:101447334G>T	uc002bwn.3	+	11	1346	c.1242G>T	c.(1240-1242)GGG>GGT	p.G414G	ALDH1A3_uc010bpb.2_Silent_p.G307G|uc002bwo.1_Intron	NM_000693	NP_000684	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1A3	414					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	AGATTTTCGGGCCAGTGCAAC	0.398													10	42					0.000442599	0.00142746	1	0	T	101447334	T	T	101447334	2	4	240	1	0	0	0	0	0	0	0	1	492	1190	42	4		4	ALDH1A3	15	101447334	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	19799248	101447334	1084058	189	44069											
ALDH1A3	220	broad.mit.edu	37	chr15	101448628	101448628	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctaggatcaactgctacaaCgccctctatgcacaggctcc	10	9	7	15	1	3	0	1	0	2	0	4	1	4	1	2	2	5	3	2	2	5	3	rs145659258		TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr15:101448628C>T	uc002bwn.3	+	12	1511	c.1407C>T	c.(1405-1407)AAC>AAT	p.N469N	ALDH1A3_uc010bpb.2_Silent_p.N362N|uc002bwo.1_Intron	NM_000693	NP_000684	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1A3	469					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	ACTGCTACAACGCCCTCTATG	0.512													10	37					0	0	0	0	T	101448628	T	T	101448628	2	4	240	1	0	0	0	0	0	0	0	1	492	535	19	1		1	ALDH1A3	15	101448628	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1294	101448628	1082764	190	44070											
STUB1	10273	broad.mit.edu	37	chr16	732456	732456	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggaggttattgacgcattCatctctgagaatggctgggt	10	12	13	6	1	2	2	1	2	1	1	3	4	2	3	0	4	0	3	0	4	3	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:732456C>T	uc002cit.2	+	7	1290	c.879C>T	c.(877-879)TTC>TTT	p.F293F	STUB1_uc002ciu.2_Silent_p.F221F|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA|JMJD8_uc002ciw.1_3'UTR|JMJD8_uc002cix.1_3'UTR|JMJD8_uc002ciy.1_3'UTR	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	293	U-box.				cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				TTGACGCATTCATCTCTGAGA	0.607													26	108					0	0	0	0	T	732456	T	T	732456	2	4	240	1	0	0	0	0	0	0	0	1	15401	825	29	2		2	STUB1	16	732456	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08		732456	89622297	191	44071											
JMJD8	339123	broad.mit.edu	37	chr16	733066	733066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggaactctggcgtcttctCaggtgggtaaaggaaccagc	9	9	14	9	1	3	0	1	0	3	0	4	2	3	2	1	5	3	1	1	5	4	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:733066C>T	uc002ciw.1	-	8	721	c.664G>A	c.(664-666)GAG>AAG	p.E222K	JMJD8_uc002cix.1_Missense_Mutation_p.E222K|JMJD8_uc002ciy.1_Missense_Mutation_p.E192K	NM_001005920	NP_001005920	Q96S16	JMJD8_HUMAN	jumonji domain containing 8	271	JmjC.									breast(1)	1						GGCGTCTTCTCAGGTGGGTAA	0.637													28	89					0	0	0	0	T	733066	T	T	733066	3	4	240	1	0	0	0	0	1	0	0	0	7995	835	29	2	201	2	JMJD8	16	733066	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	610	733066	89621687	192	44072											
RPS2	6187	broad.mit.edu	37	chr16	2015073	2015074	+	5'Flank	INS	-	TACGT	TACGT																															ccagccgcggctcgggaatcINScacccgaagagtggctataa																								rs141736343	by1000genomes	TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	3ca6c16c-0424-4e47-82d0-9e25e253944b	g.chr16:2015073_2015074insTACGT	uc002cnn.2	-						RPS2_uc010bsa.1_5'Flank|RPS2_uc002cnl.2_5'Flank|RPS2_uc002cnm.2_5'Flank|RPS2_uc002cno.2_5'Flank|SNORA10_uc002cnp.1_5'Flank|SNORA64_uc002cnq.2_5'Flank|SNHG9_uc002cnr.2_RNA|SNORA78_uc002cns.1_5'Flank|RNF151_uc002cnt.1_5'Flank	NM_002952	NP_002943	P15880	RS2_HUMAN	ribosomal protein S2						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleoplasm	fibroblast growth factor 1 binding|fibroblast growth factor 3 binding|RNA binding|structural constituent of ribosome				0						GCTCGGGAATCCACCCGAAGAG	0.649													---	---	---								TACGT	2015074	TACGT	TACGT	2015073	6	5	240	0	1	1	1	0	0	0	0	0	13696	870	30	0		0	RPS2	16	2015073	5'Flank	INS	-	TCGA-CV-7252-01A-11D-2012-08	1282007	2015073	88339680	193	44073											
TMEM159	57146	broad.mit.edu	37	chr16	21181823	21181823	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catccgtttctggccttcacCttgctggtgttcattgtcat	4	17	8	12	1	4	0	3	0	1	0	5	0	5	0	3	2	1	3	3	2	0	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:21181823C>T	uc002dif.3	+	3	523	c.162C>T	c.(160-162)ACC>ACT	p.T54T	TMEM159_uc002dig.3_RNA|TMEM159_uc010vbf.1_Silent_p.T78T|TMEM159_uc002dih.3_Silent_p.T54T	NM_020422	NP_065155	Q96B96	TM159_HUMAN	transmembrane protein 159	54						integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0972)		TGGCCTTCACCTTGCTGGTGT	0.522													38	124					0	0	0	0	T	21181823	T	T	21181823	2	4	240	1	0	0	0	0	0	0	0	1	16140	668	24	4		4	TMEM159	16	21181823	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	19166750	21181823	69172930	194	44074											
ANKS4B	257629	broad.mit.edu	37	chr16	21262063	21262063	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caaatgcagctgggtcccagGaagaaagttctgaatgctat	13	9	11	8	0	1	2	0	1	1	1	2	3	2	3	1	2	3	4	1	2	5	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:21262063G>A	uc010bwp.1	+	2	1219	c.1176G>A	c.(1174-1176)AGG>AGA	p.R392R	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	392	SAM.									ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		TGGGTCCCAGGAAGAAAGTTC	0.512													26	99					0	0	0	0	A	21262063	A	A	21262063	2	1	240	1	0	0	0	0	0	0	0	1	691	1165	41	2		2	ANKS4B	16	21262063	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	80240	21262063	69092690	195	44075											
ZNF48	197407	broad.mit.edu	37	chr16	30409298	30409298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaagcaccagcggacacacCggggggagcagcccccccga	10	1	13	17	3	1	0	1	0	0	0	1	3	1	2	5	4	4	2	5	4	1	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:30409298C>T	uc002dya.1	+	2	786	c.727C>T	c.(727-729)CGG>TGG	p.R243W	ZNF48_uc002dxz.1_Missense_Mutation_p.R120W	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCGGACACACCGGGGGGAGCA	0.647													10	61					0	0	0	0	T	30409298	T	T	30409298	3	4	240	1	0	0	0	0	1	0	0	0	18001	643	23	1	733	1	ZNF48	16	30409298	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	9147235	30409298	59945455	196	44076											
ZNF629	23361	broad.mit.edu	37	chr16	30793311	30793311	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgccgggtgagggccacgcGgtcgaggaaggaggccctgc	6	4	20	11	4	0	1	0	1	0	0	1	4	0	3	3	6	2	0	3	6	1	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:30793311G>A	uc002dzs.1	-	3	2546	c.2338C>T	c.(2338-2340)CGC>TGC	p.R780C		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	780	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			AGGGCCACGCGGTCGAGGAAG	0.647													44	145					0	0	0	0	A	30793311	A	A	30793311	3	1	240	1	0	0	0	0	1	0	0	0	18120	1116	39	1	275	1	ZNF629	16	30793311	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	384013	30793311	59561442	197	44077											
SALL1	6299	broad.mit.edu	37	chr16	51171359	51171359	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccttctggaacatttctggGaacttgacgggattgcctcc	7	13	10	11	1	2	1	0	1	2	0	4	4	4	4	3	3	3	0	3	3	2	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:51171359G>A	uc010vgs.1	-	3	3670	c.3639C>T	c.(3637-3639)TTC>TTT	p.F1213F	SALL1_uc010vgr.1_Silent_p.F1116F|SALL1_uc010cbv.2_Silent_p.F65F	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1213					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ACATTTCTGGGAACTTGACGG	0.567													13	48					0	0	0	0	A	51171359	A	A	51171359	2	1	240	1	0	0	0	0	0	0	0	1	13875	1165	41	2		2	SALL1	16	51171359	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	20378048	51171359	39183394	198	44078											
TOX3	27324	broad.mit.edu	37	chr16	52484290	52484290	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgtgtgaggcatactggCacctcccaaattcaacccca	12	8	8	13	0	1	2	1	1	0	1	2	2	2	2	4	2	2	2	4	2	3	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:52484290C>T	uc002egw.2	-	4	748	c.577G>A	c.(577-579)GCC>ACC	p.A193T	TOX3_uc010vgt.1_Missense_Mutation_p.A188T|TOX3_uc010vgu.1_Missense_Mutation_p.A193T	NM_001080430	NP_001073899	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	193					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity				0						GGCATACTGGCACCTCCCAAA	0.567													36	122					0	0	0	0	T	52484290	T	T	52484290	3	4	240	1	0	0	0	0	1	0	0	0	16446	710	25	4	1169	4	TOX3	16	52484290	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1312931	52484290	37870463	199	44079											
CDH3	1001	broad.mit.edu	37	chr16	68721545	68721545	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcgccaggtgctgaacatCacggacaaggacctgtctcc	9	7	12	13	2	2	1	1	1	1	0	3	3	2	3	3	3	3	1	3	3	2	0	rs140790125	byFrequency	TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:68721545C>T	uc002ewf.2	+	12	2833	c.1701C>T	c.(1699-1701)ATC>ATT	p.I567I	CDH3_uc010vli.1_Silent_p.I512I	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	567	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		TGCTGAACATCACGGACAAGG	0.562													25	70					0	0	0	0	T	68721545	T	T	68721545	2	4	240	1	0	0	0	0	0	0	0	1	3126	816	29	2		2	CDH3	16	68721545	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	16237255	68721545	21633208	200	44080											
MLKL	197259	broad.mit.edu	37	chr16	74719469	74719469	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgatctccttattgaaagtCtgcctcactattctataagg	10	16	6	9	0	4	2	1	2	3	0	5	2	4	2	2	1	1	0	2	1	5	7			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:74719469C>G	uc002fdb.2	-	5	1176	c.735G>C	c.(733-735)CAG>CAC	p.Q245H	MLKL_uc002fdc.2_Intron	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	245	Protein kinase.						ATP binding|protein binding|protein kinase activity			stomach(2)	2						TATTGAAAGTCTGCCTCACTA	0.313													3	23					0	0	0	0	G	74719469	G	G	74719469	3	3	240	1	0	0	0	0	1	0	0	0	9672	912	32	2	739	2	MLKL	16	74719469	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	5997924	74719469	15635284	201	44081											
JPH3	57338	broad.mit.edu	37	chr16	87636924	87636924	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgtctacacctggcccagcGgcaacacgtaccagggcacc	9	4	11	17	3	1	0	0	0	1	0	1	0	1	0	4	3	4	3	4	3	3	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr16:87636924G>A	uc002fkd.2	+	1	426	c.172G>A	c.(172-174)GGC>AGC	p.G58S	JPH3_uc010vou.1_Intron	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	58	Gly-rich.|Cytoplasmic (Potential).|MORN 2.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CTGGCCCAGCGGCAACACGTA	0.682													9	27					0	0	0	0	A	87636924	A	A	87636924	3	1	240	1	0	0	0	0	1	0	0	0	8001	1116	39	1	174	1	JPH3	16	87636924	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	12917455	87636924	2717829	202	44082											
ABR	29	broad.mit.edu	37	chr17	961286	961286	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacagtaggaacaggtaactCtgaagagaggagataagcat	17	6	13	5	0	1	3	0	1	1	2	1	7	1	4	0	3	3	3	0	3	5	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:961286C>T	uc002fsd.2	-	12	1416	c.1306_splice	c.e12-1	p.S436_splice	ABR_uc002fse.2_Splice_Site_p.S390_splice|ABR_uc010vqg.1_Splice_Site_p.S218_splice|ABR_uc002fsg.2_Splice_Site_p.S399_splice|ABR_uc002fsh.1_Intron	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		ACAGGTAACTCTGAAGAGAGG	0.463													9	30					0	0	0	0	T	961286	T	T	961286	5	4	240	1	0	0	0	0	0	0	1	0	99	927	32	2	1322	2	ABR	17	961286	Splice_Site	SNP	C	TCGA-CV-7252-01A-11D-2012-08		961286	80233924	203	44083											
SMYD4	114826	broad.mit.edu	37	chr17	1704088	1704088	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttctgtgagactgtccttTtcttgcatcttcattttcag	5	20	6	10	0	5	1	2	1	3	1	6	2	6	1	1	0	1	1	1	0	0	7			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:1704088T>C	uc002ftm.3	-	5	768	c.600A>G	c.(598-600)GAA>GAG	p.E200E	SMYD4_uc002ftn.1_Silent_p.E55E	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	200							zinc ion binding			skin(3)|kidney(2)	5						GACTGTCCTTTTCTTGCATCT	0.498													48	164					0	0	0	0	C	1704088	C	C	1704088	2	2	240	1	0	0	0	0	0	0	0	1	14888	1838	64	5		5	SMYD4	17	1704088	Silent	SNP	T	TCGA-CV-7252-01A-11D-2012-08	742802	1704088	79491122	204	44084											
XAF1	54739	broad.mit.edu	37	chr17	6665481	6665481	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcttattcaggggaaagAatttcagctcctgaaaggga	12	11	11	7	0	3	2	2	1	1	1	4	4	4	4	1	3	2	2	1	3	4	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:6665481A>G	uc002gdn.2	+	5	671	c.429A>G	c.(427-429)AGA>AGG	p.R143R	XAF1_uc002gdm.1_Silent_p.R83R|XAF1_uc002gdo.2_Silent_p.R124R|XAF1_uc002gdp.2_Intron|XAF1_uc002gdq.2_5'UTR|XAF1_uc002gdr.2_Intron	NM_017523	NP_059993	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1 isoform 1	143					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding				0						CAGGGGAAAGAATTTCAGCTC	0.413													9	21					0	0	0	0	G	6665481	G	G	6665481	2	3	240	1	0	0	0	0	0	0	0	1	17487	243	9	5		5	XAF1	17	6665481	Silent	SNP	A	TCGA-CV-7252-01A-11D-2012-08	4961393	6665481	74529729	205	44085											
TP53	7157	broad.mit.edu	37	chr17	7578267	7578268	+	Frame_Shift_Ins	INS	-	AG	AG																															aatttccttccactcggataINSagatgctgaggaggggccag																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:7578267_7578268insAG	uc002gim.2	-	6	775_776	c.581_582insCT	c.(580-582)CTTfs	p.L194fs	TP53_uc002gig.1_Frame_Shift_Ins_p.L194fs|TP53_uc002gih.2_Frame_Shift_Ins_p.L194fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.L62fs|TP53_uc010cng.1_Frame_Shift_Ins_p.L62fs|TP53_uc002gii.1_Frame_Shift_Ins_p.L62fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.L194fs|TP53_uc010cni.1_Frame_Shift_Ins_p.L194fs|TP53_uc002gij.2_Frame_Shift_Ins_p.L194fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Ins_p.L101fs|TP53_uc002gio.2_Frame_Shift_Ins_p.L62fs|TP53_uc010vug.1_Frame_Shift_Ins_p.L155fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	194	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> H (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L194R(31)|p.L194F(16)|p.L194P(8)|p.0?(7)|p.L194H(5)|p.L194L(4)|p.A189_V197delAPPQHLIRV(4)|p.P191fs*53(2)|p.L194fs*15(2)|p.K164_P219del(1)|p.L194V(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.I195fs*14(1)|p.I195fs*12(1)|p.I195fs*50(1)|p.L194fs*14(1)|p.L194fs*52(1)|p.A189fs*53(1)|p.L194I(1)|p.I195fs*52(1)|p.H193_I195>AP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCACTCGGATAAGATGCTGAGG	0.554		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								AG	7578268	AG	AG	7578267	7	5	240	1	0	1	1	0	0	0	0	0	16448	349	13	0	712	0	TP53	17	7578267	Frame_Shift_Ins	INS	-	TCGA-CV-7252-01A-11D-2012-08	912786	7578267	73616943	206	44086											
TP53	7157	broad.mit.edu	37	chr17	7579533	7579533	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggtcttcagtgaaccattGttcaatatcgtccggggaca	9	12	11	9	2	3	1	2	1	1	0	5	2	4	2	2	3	1	1	2	3	3	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:7579533G>A	uc002gim.2	-	4	348	c.154C>T	c.(154-156)CAA>TAA	p.Q52*	TP53_uc002gig.1_Nonsense_Mutation_p.Q52*|TP53_uc002gih.2_Nonsense_Mutation_p.Q52*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.Q52*|TP53_uc010cni.1_Nonsense_Mutation_p.Q52*|TP53_uc002gij.2_Nonsense_Mutation_p.Q52*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.Q13*|TP53_uc010cnk.1_Nonsense_Mutation_p.Q67*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	52	TADII.|Interaction with HRMT1L2.		Q -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.Q52*(6)|p.Q52>P*(1)|p.Q52H(1)|p.E51fs*59(1)|p.I50fs*4(1)|p.D48fs*55(1)|p.Q52fs*67(1)|p.Q52fs*6(1)|p.E51_Q52insX(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGAACCATTGTTCAATATCG	0.582		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			67	183					0	0	0	0	A	7579533	A	A	7579533	4	1	240	1	0	0	0	0	0	1	0	0	16448	1386	48	4	1148	4	TP53	17	7579533	Nonsense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1266	7579533	73615677	207	44087											
MYH4	4622	broad.mit.edu	37	chr17	10348460	10348460	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcctcagccatcatggCagcctagttagcaaataaat	13	9	7	12	0	2	0	2	0	0	0	3	0	3	0	3	1	4	4	3	1	5	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:10348460C>A	uc002gmn.2	-	37	5410	c.5299G>T	c.(5299-5301)GCC>TCC	p.A1767S	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1767	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GCCATCATGGCAGCCTAGTTA	0.473													53	159					3.4597e-24	1.25737e-23	1	0	A	10348460	A	A	10348460	3	1	240	1	0	0	0	0	1	0	0	0	10090	710	25	4	536	4	MYH4	17	10348460	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	2768927	10348460	70846750	208	44088											
NCOR1	9611	broad.mit.edu	37	chr17	15964844	15964844	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttccctctggtccttagctCttcctcatatctggattttg	4	18	6	13	0	4	0	1	0	3	0	7	1	7	1	3	2	1	1	3	2	2	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:15964844C>G	uc002gpo.2	-	37	5992	c.5752G>C	c.(5752-5754)GAG>CAG	p.E1918Q	NCOR1_uc002gpn.2_Intron|NCOR1_uc002gpm.2_Missense_Mutation_p.E438Q|NCOR1_uc010vwb.1_Missense_Mutation_p.E502Q|NCOR1_uc010coy.2_Missense_Mutation_p.E826Q|NCOR1_uc010vwc.1_Missense_Mutation_p.E728Q	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1918	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTCCTTAGCTCTTCCTCATAT	0.498													59	192					0	0	0	0	G	15964844	G	G	15964844	3	3	240	1	0	0	0	0	1	0	0	0	10289	922	32	2	1610	2	NCOR1	17	15964844	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	5616384	15964844	65230366	209	44089											
RAI1	10743	broad.mit.edu	37	chr17	17700989	17700989	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccgcagagcctgaaatccGcctcaagtacatttcctctt	9	11	6	15	2	2	2	1	1	1	1	5	2	5	2	5	0	2	2	5	0	3	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:17700989G>A	uc002grm.2	+	3	5196	c.4727G>A	c.(4726-4728)CGC>CAC	p.R1576H	RAI1_uc002grn.1_Missense_Mutation_p.R1576H	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1576						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CCTGAAATCCGCCTCAAGTAC	0.637													33	104					0	0	0	0	A	17700989	A	A	17700989	3	1	240	1	0	0	0	0	1	0	0	0	13072	1087	38	1	4729	1	RAI1	17	17700989	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1736145	17700989	63494221	210	44090											
CPD	1362	broad.mit.edu	37	chr17	28706100	28706100	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcggcccgggcggctcacatCaagaaggcggaggcgactac	9	4	15	13	5	2	1	2	0	0	1	3	3	2	2	1	6	1	1	1	6	3	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:28706100C>G	uc002hfb.1	+	1	117	c.102C>G	c.(100-102)ATC>ATG	p.I34M	CPD_uc010wbo.1_5'Flank|CPD_uc010wbp.1_5'Flank	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	34	Extracellular (Potential).|Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						CGGCTCACATCAAGAAGGCGG	0.706													3	5					0	0	0	0	G	28706100	G	G	28706100	3	3	240	1	0	0	0	0	1	0	0	0	3813	816	29	2	104	2	CPD	17	28706100	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	11005111	28706100	52489110	211	44091											
NEUROD2	4761	broad.mit.edu	37	chr17	37761719	37761719	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagtctcagttatgaaaaaaCgcattgagctcctcgtacat	14	11	7	9	2	1	2	1	2	1	0	4	2	2	2	1	0	3	4	1	0	6	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:37761719C>A	uc002hry.2	-	2	1334	c.1134G>T	c.(1132-1134)GCG>GCT	p.A378A		NM_006160	NP_006151	Q15784	NDF2_HUMAN	neurogenic differentiation 2	378					cellular response to calcium ion|cellular response to electrical stimulus|cerebellar cortex development|negative regulation of synapse maturation|positive regulation of calcium-mediated signaling|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of synapse maturation|positive regulation of synaptic plasticity|protein ubiquitination|regulation of transcription from RNA polymerase II promoter	nucleus	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Lung(15;0.00549)|LUAD - Lung adenocarcinoma(14;0.0664)			TATGAAAAAACGCATTGAGCT	0.612													6	15					0.00198382	0.00635605	1	0	A	37761719	A	A	37761719	2	1	240	1	0	0	0	0	0	0	0	1	10403	523	19	3		3	NEUROD2	17	37761719	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	9055619	37761719	43433491	212	44092											
THRA	7067	broad.mit.edu	37	chr17	38245491	38245491	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgctgtgtgtggacaagatcGagaagagtcaggaggcgtac	11	8	16	6	2	1	3	1	0	0	3	2	6	1	5	0	3	2	2	0	3	3	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:38245491G>C	uc002htw.2	+	9	1498	c.1015G>C	c.(1015-1017)GAG>CAG	p.E339Q	THRA_uc010cwp.1_Missense_Mutation_p.E339Q|THRA_uc002htv.2_Missense_Mutation_p.E339Q|THRA_uc002htx.2_Missense_Mutation_p.E339Q	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	339	Ligand-binding.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	GGACAAGATCGAGAAGAGTCA	0.393													23	116					0	0	0	0	C	38245491	C	C	38245491	3	2	240	1	0	0	0	0	1	0	0	0	15939	1059	37	3	1045	3	THRA	17	38245491	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	483772	38245491	42949719	213	44093											
KRTAP4-3	85290	broad.mit.edu	37	chr17	39324347	39324347	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtggtctggcagcagctgggGcggcagcagctctcctggcc	4	7	17	13	1	2	0	0	0	2	0	3	0	2	0	2	6	4	6	2	6	0	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	3ca6c16c-0424-4e47-82d0-9e25e253944b	g.chr17:39324347G>T	uc010cxl.2	-	1	78	c.78C>A	c.(76-78)CGC>CGA	p.R26R		NM_033187	NP_149443	Q9BYR4	KRA43_HUMAN	keratin associated protein 4-3	26						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			AGCAGCTGGGGCGGCAGCAGC	0.438													8	65					0.000673444	0.00168032	1	0	T	39324347	T	T	39324347	2	4	240	1	0	0	0	0	0	0	0	1	8592	1190	42	4		4	KRTAP4-3	17	39324347	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1078856	39324347	41870863	214	44094											
PSME3	10197	broad.mit.edu	37	chr17	40986892	40986892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tagccatgatggactggatgGtgtaagtgtcctatatttat	10	15	11	5	0	0	1	0	1	0	0	1	3	1	3	2	3	1	1	2	3	5	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:40986892G>A	uc002ibr.2	+	4	468	c.242G>A	c.(241-243)GGT>GAT	p.G81D	PSME3_uc002ibp.2_Missense_Mutation_p.G20D|PSME3_uc002ibq.2_Missense_Mutation_p.G81D|PSME3_uc002ibs.2_Missense_Mutation_p.G92D|PSME3_uc010whd.1_Missense_Mutation_p.V6I	NM_005789	NP_005780	P61289	PSME3_HUMAN	proteasome activator subunit 3 isoform 1	81					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome activator complex	endopeptidase activator activity|identical protein binding|MDM2 binding|p53 binding				0		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		GGACTGGATGGTGTAAGTGTC	0.443													14	50					0	0	0	0	A	40986892	A	A	40986892	3	1	240	1	0	0	0	0	1	0	0	0	12770	1275	44	4	256	4	PSME3	17	40986892	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1662545	40986892	40208318	215	44095											
AOC3	8639	broad.mit.edu	37	chr17	41006513	41006513	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatggtctttgtccccatggCtgtgccctggagccctgagc	4	12	12	13	0	1	1	0	1	1	0	2	2	2	2	4	3	3	1	4	3	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr17:41006513C>A	uc002ibv.2	+	2	1809	c.1649C>A	c.(1648-1650)GCT>GAT	p.A550D		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	550	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	GTCCCCATGGCTGTGCCCTGG	0.662													17	48					8.00594e-06	2.65231e-05	1	0	A	41006513	A	A	41006513	3	1	240	1	0	0	0	0	1	0	0	0	728	797	28	4	1655	4	AOC3	17	41006513	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	19621	41006513	40188697	216	44096											
EMILIN2	84034	broad.mit.edu	37	chr18	2891362	2891362	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtcaacagatcaagacattgGaccagaaaatcgagagagtt	17	7	10	7	1	2	4	2	0	0	4	3	7	2	5	1	1	1	1	1	1	4	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr18:2891362G>A	uc002kln.2	+	4	1396	c.1237G>A	c.(1237-1239)GAC>AAC	p.D413N		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	413					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CAAGACATTGGACCAGAAAAT	0.473													9	45					0	0	0	0	A	2891362	A	A	2891362	3	1	240	1	0	0	0	0	1	0	0	0	5118	1174	41	2	1251	2	EMILIN2	18	2891362	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08		2891362	75185886	217	44097											
WDR7	23335	broad.mit.edu	37	chr18	54423844	54423844	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaatattctcataactccCtgatggttcaagcaataaag	15	12	5	9	0	2	1	2	1	1	0	4	1	3	1	1	1	2	2	1	1	8	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr18:54423844C>T	uc002lgk.1	+	15	2231	c.2020C>T	c.(2020-2022)CTG>TTG	p.L674L	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Silent_p.L674L	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	674										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TCATAACTCCCTGATGGTTCA	0.299													16	64					0	0	0	0	T	54423844	T	T	54423844	2	4	240	1	0	0	0	0	0	0	0	1	17388	680	24	4		4	WDR7	18	54423844	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	51532482	54423844	23653404	218	44098											
PIAS4	51588	broad.mit.edu	37	chr19	4037462	4037462	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcccgatccgcgccgaaaaGgagcgcagctgcagcccgca	9	3	13	16	6	0	0	0	0	0	0	1	3	1	1	4	1	5	4	4	1	2	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:4037462G>A	uc002lzg.2	+	10	1243	c.1233G>A	c.(1231-1233)AAG>AAA	p.K411K		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	411					positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCCGAAAAGGAGCGCAGCT	0.687													8	31					0	0	0	0	A	4037462	A	A	4037462	2	1	240	1	0	0	0	0	0	0	0	1	11933	991	35	4		4	PIAS4	19	4037462	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08		4037462	55091521	219	44099											
TMEM146	257062	broad.mit.edu	37	chr19	5733907	5733907	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcagcacattttgctggttCgttattgctgttagtagtgg	7	17	11	6	1	1	0	1	0	0	0	2	0	1	0	0	2	3	7	0	2	3	7			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:5733907C>T	uc002mda.2	+	5	378	c.317C>T	c.(316-318)TCG>TTG	p.S106L	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	106	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTTGCTGGTTCGTTATTGCTG	0.313													10	40					0	0	0	0	T	5733907	T	T	5733907	3	4	240	1	0	0	0	0	1	0	0	0	16126	893	31	1	335	1	TMEM146	19	5733907	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1696445	5733907	53395076	220	44100											
CD209	30835	broad.mit.edu	37	chr19	7809868	7809868	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacgacgagctgggcccccaCttctttgcaggcggtgatgg	6	9	14	12	3	1	1	0	1	1	0	1	3	1	1	2	4	3	2	2	4	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:7809868C>T	uc002mht.2	-	5	926	c.859G>A	c.(859-861)GTG>ATG	p.V287M	CD209_uc010xju.1_Missense_Mutation_p.V126M|CD209_uc010dvp.2_Missense_Mutation_p.V263M|CD209_uc002mhr.2_Missense_Mutation_p.V263M|CD209_uc002mhs.2_Missense_Mutation_p.V217M|CD209_uc002mhu.2_Missense_Mutation_p.V195M|CD209_uc010dvq.2_Missense_Mutation_p.V287M|CD209_uc002mhq.2_Missense_Mutation_p.V287M|CD209_uc002mhv.2_Missense_Mutation_p.V263M|CD209_uc002mhx.2_Missense_Mutation_p.V243M|CD209_uc002mhw.2_Missense_Mutation_p.V151M|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	287	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						TGGGCCCCCACTTCTTTGCAG	0.587													17	80					0	0	0	0	T	7809868	T	T	7809868	3	4	240	1	0	0	0	0	1	0	0	0	2999	565	20	4	367	4	CD209	19	7809868	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	2075961	7809868	51319115	221	44101											
MUC16	94025	broad.mit.edu	37	chr19	9061995	9061995	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgattctgtcataatggggGaagtagaaagcctggtgatc	11	11	13	6	0	2	3	1	2	1	1	3	4	2	4	1	3	1	1	1	3	4	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:9061995G>A	uc002mkp.2	-	3	25655	c.25451C>T	c.(25450-25452)TCC>TTC	p.S8484F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8486	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CATAATGGGGGAAGTAGAAAG	0.488													70	205					0	0	0	0	A	9061995	A	A	9061995	3	1	240	1	0	0	0	0	1	0	0	0	10026	1174	41	2	18400	2	MUC16	19	9061995	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1252127	9061995	50066988	222	44102											
RAVER1	125950	broad.mit.edu	37	chr19	10444126	10444126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcatcgccggcttcgacttCggccccagacttagggctca	6	8	12	15	4	1	1	1	0	0	1	4	2	1	1	3	4	0	3	3	4	1	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:10444126C>T	uc002moa.2	-	1	189	c.109G>A	c.(109-111)GAA>AAA	p.E37K		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	20						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			GCTTCGACTTCGGCCCCAGAC	0.692													26	50					0	0	0	0	T	10444126	T	T	10444126	3	4	240	1	0	0	0	0	1	0	0	0	13159	893	31	1	2213	1	RAVER1	19	10444126	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1382131	10444126	48684857	223	44103											
YIPF2	78992	broad.mit.edu	37	chr19	11038362	11038364	+	In_Frame_Del	DEL	GCT	-	-																															gctgaaggtccagaatcccgGctgctgctgctgctgctgct																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	3ca6c16c-0424-4e47-82d0-9e25e253944b	g.chr19:11038362_11038364delGCT	uc002mqb.2	-	4	345_347	c.221_223delAGC	c.(220-225)CAGCCG>CCG	p.Q74del	YIPF2_uc002mqc.2_In_Frame_Del_p.Q74del|C19orf52_uc002mqd.1_5'Flank	NM_024029	NP_076934	Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	74	Cytoplasmic (Potential).					integral to membrane|transport vesicle					0						CAGAATCCCGgctgctgctgctg	0.532													---	---	---								-	11038364	-	-	11038362	7	5	240	1	0	1	0	1	0	0	0	0	17546	1203	42	0	751	0	YIPF2	19	11038362	In_Frame_Del	DEL	GCT	TCGA-CV-7252-01A-11D-2012-08	594236	11038362	48090621	224	44104											
ZNF442	79973	broad.mit.edu	37	chr19	12474424	12474424	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggaagagatcacttctgtCttctcccccaaatacaatca	14	10	5	12	0	5	1	2	0	3	1	6	3	5	2	2	1	1	0	2	1	5	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:12474424C>G	uc002mtr.1	-	3	633	c.22G>C	c.(22-24)GAC>CAC	p.D8H	ZNF442_uc010xmk.1_Intron	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						TCACTTCTGTCTTCTCCCCCA	0.473													22	99					0	0	0	0	G	12474424	G	G	12474424	3	3	240	1	0	0	0	0	1	0	0	0	17982	913	32	2	1877	2	ZNF442	19	12474424	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1436062	12474424	46654559	225	44105											
ZNF799	90576	broad.mit.edu	37	chr19	12491594	12491594	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttttcatgtcttagacaaGaactgtaatcagggaaggct	12	14	9	6	0	3	2	2	0	1	2	3	3	3	3	0	2	1	2	0	2	5	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:12491594G>A	uc002mts.3	-	4	948	c.482C>T	c.(481-483)TCT>TTT	p.S161F				Q96GE5	ZN799_HUMAN	Homo sapiens cDNA clone IMAGE:30340957, **** WARNING: chimeric clone ****.	267	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TCTTAGACAAGAACTGTAATC	0.388													27	83					0	0	0	0	A	12491594	A	A	12491594	3	1	240	1	0	0	0	0	1	0	0	0	18233	957	33	2		2	ZNF799	19	12491594	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	17170	12491594	46637389	226	44106											
ZSWIM4	65249	broad.mit.edu	37	chr19	13928082	13928082	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aacaccgaaggatgggtgggGcaccccctggaccccattgg	9	5	14	13	1	0	0	0	0	0	0	0	3	0	2	5	6	1	1	5	6	2	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:13928082G>A	uc002mxh.1	+	7	1422	c.1233G>A	c.(1231-1233)GGG>GGA	p.G411G	ZSWIM4_uc010xng.1_Silent_p.G334G	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	411							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			GATGGGTGGGGCACCCCCTGG	0.622													29	72					0	0	0	0	A	13928082	A	A	13928082	2	1	240	1	0	0	0	0	0	0	0	1	18310	1190	42	4		4	ZSWIM4	19	13928082	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1436488	13928082	45200901	227	44107											
GMIP	51291	broad.mit.edu	37	chr19	19744918	19744929	+	In_Frame_Del	DEL	CGGCGGCCGCAG	-	-																															ctggctgcccgcgggccgtcCggcggccgcagcagtgtcgg																								rs144433615	by1000genomes	TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:19744918_19744929delCGGCGGCCGCAG	uc002nnd.2	-	19	2272_2283	c.2155_2166delCTGCGGCCGCCG	c.(2155-2166)CTGCGGCCGCCGdel	p.LRPP719del	GMIP_uc010xrb.1_In_Frame_Del_p.LRPP693del|GMIP_uc010xrc.1_In_Frame_Del_p.LRPP690del	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	719_722	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						GCGGGCCGTCCGGCGGCCGCAGCAGTGTCGGC	0.613													---	---	---								-	19744929	-	-	19744918	7	5	240	1	0	1	0	1	0	0	0	0	6528	639	23	0	758	0	GMIP	19	19744918	In_Frame_Del	DEL	CGGCGGCCGCAG	TCGA-CV-7252-01A-11D-2012-08	5816836	19744918	39384065	228	44108											
MLL4	9757	broad.mit.edu	37	chr19	36218454	36218474	+	In_Frame_Del	DEL	GGGCCTGCGCCAGGTGCTCCA	-	-																															ctgagcggggccctccagggGggcctgcgccaggtgctcca																								rs34078597		TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:36218454_36218474delGGGCCTGCGCCAGGTGCTCCA	uc010eei.2	+	17	4233_4253	c.4233_4253delGGGCCTGCGCCAGGTGCTCCA	c.(4231-4254)GGGGGCCTGCGCCAGGTGCTCCAG>GGG	p.GLRQVLQ1412del		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1412_1418					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCTCCAGGGGGGCCTGCGCCAGGTGCTCCAGGGCCTGCTG	0.724													---	---	---								-	36218474	-	-	36218454	7	5	240	1	0	1	0	1	0	0	0	0	9676	1219	43	0	4295	0	MLL4	19	36218454	In_Frame_Del	DEL	GGGCCTGCGCCAGGTGCTCCA	TCGA-CV-7252-01A-11D-2012-08	16473536	36218454	22910529	229	44109											
MLL4	9757	broad.mit.edu	37	chr19	36228844	36228844	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaagctgtgggtgtctacagGtgagtggggttgggggggag	6	9	23	3	0	1	1	0	1	1	0	1	3	1	2	0	7	2	2	0	7	2	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:36228844G>C	uc010eei.2	+	36	7742	c.7742_splice	c.e36+1	p.R2581_splice		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4						chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTGTCTACAGGTGAGTGGGGT	0.612													7	10					0	0	0	0	C	36228844	C	C	36228844	5	2	240	1	0	0	0	0	0	0	1	0	9676	1275	44	4	7881	4	MLL4	19	36228844	Splice_Site	SNP	G	TCGA-CV-7252-01A-11D-2012-08	10390	36228844	22900139	230	44110											
FCGBP	8857	broad.mit.edu	37	chr19	40368526	40368526	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgcagaagccagggccctcGtactgctccaaccggtcctc	7	6	10	18	3	0	1	0	0	0	1	4	1	2	1	6	2	4	3	6	2	3	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:40368526G>A	uc002omp.3	-	28	12830	c.12822C>T	c.(12820-12822)TAC>TAT	p.Y4274Y		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4274	VWFD 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CAGGGCCCTCGTACTGCTCCA	0.657													6	80					0	0	0	0	A	40368526	A	A	40368526	2	1	240	1	0	0	0	0	0	0	0	1	5810	1140	40	1		1	FCGBP	19	40368526	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	4139682	40368526	18760457	231	44111											
MAP3K10	4294	broad.mit.edu	37	chr19	40704316	40704316	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccatcgagaaccacaacctCgcagacacggtgctcaagat	13	5	9	14	3	1	3	1	0	0	3	3	4	1	3	3	1	3	2	3	1	3	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:40704316C>T	uc002ona.2	+	2	1005	c.717C>T	c.(715-717)CTC>CTT	p.L239L	MAP3K10_uc002onb.2_5'UTR	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	239	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						ACCACAACCTCGCAGACACGG	0.647													14	44					0	0	0	0	T	40704316	T	T	40704316	2	4	240	1	0	0	0	0	0	0	0	1	9297	871	31	1		1	MAP3K10	19	40704316	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	335790	40704316	18424667	232	44112											
AKT2	208	broad.mit.edu	37	chr19	40739814	40739814	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggccgagtaggagaactgggGgaagtgggtccgctggtcca	8	6	19	8	2	0	1	0	0	0	1	2	4	2	2	3	6	1	2	3	6	3	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:40739814G>A	uc002onf.2	-	14	1673	c.1411C>T	c.(1411-1413)CCC>TCC	p.P471S	AKT2_uc010egs.2_Missense_Mutation_p.P428S|AKT2_uc010egt.2_Missense_Mutation_p.P409S|AKT2_uc010xvj.1_Missense_Mutation_p.P409S|AKT2_uc002one.2_Missense_Mutation_p.P367S	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	471	AGC-kinase C-terminal.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)			GAGAACTGGGGGAAGTGGGTC	0.642			A		ovarian|pancreatic 								10	26					0	0	0	0	A	40739814	A	A	40739814	3	1	240	1	0	0	0	0	1	0	0	0	480	1232	43	4	38	4	AKT2	19	40739814	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	35498	40739814	18389169	233	44113											
ZNF224	7767	broad.mit.edu	37	chr19	44611712	44611712	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatgtgggaagagctttagtCgggccccatgtcttttgaaa	10	12	12	7	1	1	2	0	1	1	1	2	3	1	3	2	2	1	1	2	2	4	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:44611712C>T	uc002oyh.1	+	6	1701	c.1399C>T	c.(1399-1401)CGG>TGG	p.R467W	uc002oyi.2_RNA	NM_013398	NP_037530	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	467	C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				GAGCTTTAGTCGGGCCCCATG	0.438													19	62					0	0	0	0	T	44611712	T	T	44611712	3	4	240	1	0	0	0	0	1	0	0	0	17845	875	31	1	1413	1	ZNF224	19	44611712	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	3871898	44611712	14517271	234	44114											
NOVA2	4858	broad.mit.edu	37	chr19	46443312	46443312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtcagctcctggtactccaCcaacgtcttgccccccttcc	5	10	6	20	2	2	0	1	0	1	0	5	0	5	0	7	1	4	2	7	1	2	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:46443312C>T	uc002pdv.2	-	4	1336	c.1288G>A	c.(1288-1290)GTG>ATG	p.V430M		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	430	KH 3.					nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		TGGTACTCCACCAACGTCTTG	0.662													43	124					0	0	0	0	T	46443312	T	T	46443312	3	4	240	1	0	0	0	0	1	0	0	0	10609	507	18	4	194	4	NOVA2	19	46443312	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1831600	46443312	12685671	235	44115											
AKT1S1	84335	broad.mit.edu	37	chr19	50374957	50374957	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggggccggcgggggtctcCtcgctcaggctgccatctga	3	7	18	13	3	3	1	1	1	2	0	5	1	3	1	3	7	1	2	3	7	0	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:50374957C>T	uc002pql.3	-	4	1200	c.474G>A	c.(472-474)GAG>GAA	p.E158E	AKT1S1_uc002pqn.3_Silent_p.E158E|AKT1S1_uc002pqm.3_Silent_p.E158E	NM_032375	NP_115751	Q96B36	AKTS1_HUMAN	AKT1 substrate 1 (proline-rich)	158					negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|nerve growth factor receptor signaling pathway|neuroprotection|phosphatidylinositol-mediated signaling|regulation of survival gene product expression	cytosolic part	protein binding				0		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		CGGGGGTCTCCTCGCTCAGGC	0.667													26	72					0	0	0	0	T	50374957	T	T	50374957	2	4	240	1	0	0	0	0	0	0	0	1	479	680	24	4		4	AKT1S1	19	50374957	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	3931645	50374957	8754026	236	44116											
SHANK1	50944	broad.mit.edu	37	chr19	51192464	51192464	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcactcacccttggccccCcggagcacgaacccaaaccc	9	4	8	20	2	1	0	1	0	0	0	1	2	1	1	6	3	3	2	6	3	2	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:51192464C>T	uc002psx.1	-	15	2056	c.2037G>A	c.(2035-2037)CGG>CGA	p.R679R	SHANK1_uc002psw.1_Silent_p.R63R	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	679	PDZ.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CCTTGGCCCCCCGGAGCACGA	0.612													11	94					0	0	0	0	T	51192464	T	T	51192464	2	4	240	1	0	0	0	0	0	0	0	1	14329	610	22	4		4	SHANK1	19	51192464	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	817507	51192464	7936519	237	44117											
TMC4	147798	broad.mit.edu	37	chr19	54664964	54664964	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcggaggcccggaaggtgcGggcagccggggagcaggtgg	6	2	23	10	5	0	0	0	0	0	0	0	3	0	3	2	9	3	2	2	9	1	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:54664964G>A	uc010erf.2	-	12	1870	c.1738C>T	c.(1738-1740)CGC>TGC	p.R580C	LENG1_uc002qdm.2_5'Flank|TMC4_uc002qdn.2_Missense_Mutation_p.R294C|TMC4_uc002qdo.2_Missense_Mutation_p.R574C	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	580	Cytoplasmic (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CGGAAGGTGCGGGCAGCCGGG	0.562													8	19					0	0	0	0	A	54664964	A	A	54664964	3	1	240	1	0	0	0	0	1	0	0	0	16053	1116	39	1	416	1	TMC4	19	54664964	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	3472500	54664964	4464019	238	44118											
ZNF211	10520	broad.mit.edu	37	chr19	58152875	58152875	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcacactggagaaaggcctTatgaatgtggggaatgtggg	11	10	15	5	0	1	2	1	1	0	1	1	4	1	3	1	5	0	0	1	5	4	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr19:58152875T>C	uc002qpq.2	+	3	1201	c.1021T>C	c.(1021-1023)TAT>CAT	p.Y341H	ZNF211_uc010yhb.1_Missense_Mutation_p.Y345H|ZNF211_uc002qpp.2_Missense_Mutation_p.Y354H|ZNF211_uc002qpr.2_Missense_Mutation_p.Y405H|ZNF211_uc002qps.2_Missense_Mutation_p.Y406H|ZNF211_uc002qpt.2_Missense_Mutation_p.Y353H|ZNF211_uc010yhc.1_Missense_Mutation_p.Y353H|ZNF211_uc010yhd.1_Missense_Mutation_p.Y280H|ZNF211_uc010yhe.1_Missense_Mutation_p.Y332H	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	341	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGAAAGGCCTTATGAATGTGG	0.463													17	56					0	0	0	0	C	58152875	C	C	58152875	3	2	240	1	0	0	0	0	1	0	0	0	17834	1754	61	5	1074	5	ZNF211	19	58152875	Missense_Mutation	SNP	T	TCGA-CV-7252-01A-11D-2012-08	3487911	58152875	976108	239	44119											
NSFL1C	55968	broad.mit.edu	37	chr20	1433208	1433208	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttcacaaagtcctcgtcccGatggtcctccatatccaagt	9	11	6	15	2	1	0	1	0	0	0	7	1	6	0	5	1	0	0	5	1	3	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr20:1433208G>A	uc002wfc.2	-	7	1663	c.715C>T	c.(715-717)CGG>TGG	p.R239W	NSFL1C_uc002wfd.2_Missense_Mutation_p.R128W|NSFL1C_uc002wfe.2_Missense_Mutation_p.R208W|NSFL1C_uc002wff.2_RNA|NSFL1C_uc010gag.2_Missense_Mutation_p.R5W	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	239	SEP.					chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						TCCTCGTCCCGATGGTCCTCC	0.572													55	144					0	0	0	0	A	1433208	A	A	1433208	3	1	240	1	0	0	0	0	1	0	0	0	10726	1057	37	1	409	1	NSFL1C	20	1433208	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08		1433208	61592312	240	44120											
SIRPA	140885	broad.mit.edu	37	chr20	1895762	1895762	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caggagtggcgggtgaggagGagctgcaggtgattcagcct	8	7	19	7	1	1	2	1	2	0	0	1	5	1	5	1	6	3	2	1	6	0	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr20:1895762G>A	uc002wfq.2	+	3	457	c.97G>A	c.(97-99)GAG>AAG	p.E33K	SIRPA_uc010zps.1_Intron|SIRPA_uc002wfr.2_Missense_Mutation_p.E33K|SIRPA_uc002wfs.2_Missense_Mutation_p.E33K|SIRPA_uc002wft.2_Missense_Mutation_p.E33K	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	33	Ig-like V-type.|Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GGGTGAGGAGGAGCTGCAGGT	0.527													11	15					0	0	0	0	A	1895762	A	A	1895762	3	1	240	1	0	0	0	0	1	0	0	0	14397	1175	41	2	103	2	SIRPA	20	1895762	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	462554	1895762	61129758	241	44121											
CST1	1469	broad.mit.edu	37	chr20	23731395	23731395	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccactcatcattgaggtctgCgttatagatgccacccggga	9	10	10	12	2	3	2	2	1	1	1	3	3	3	3	3	2	2	1	3	2	2	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr20:23731395C>T	uc002wtp.2	-	1	180	c.109G>A	c.(109-111)GCA>ACA	p.A37T		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	37						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					TTGAGGTCTGCGTTATAGATG	0.572													10	50					0	0	0	0	T	23731395	T	T	23731395	3	4	240	1	0	0	0	0	1	0	0	0	3987	768	27	1	328	1	CST1	20	23731395	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	21835633	23731395	39294125	242	44122											
C20orf152	140894	broad.mit.edu	37	chr20	34596243	34596243	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctctcctatggaaagatttaAggaattccagatcaaatcat	15	12	6	8	0	3	2	2	0	1	2	5	4	4	4	2	2	0	0	2	2	5	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr20:34596243A>G	uc002xes.1	+	9	1151	c.995A>G	c.(994-996)AAG>AGG	p.K332R	C20orf152_uc002xer.1_Missense_Mutation_p.K332R|C20orf152_uc010gfp.1_RNA			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	332											0	Breast(12;0.00631)					GAAAGATTTAAGGAATTCCAG	0.408													37	110					0	0	0	0	G	34596243	G	G	34596243	3	3	240	1	0	0	0	0	1	0	0	0	2102	72	3	5	1029	5	C20orf152	20	34596243	Missense_Mutation	SNP	A	TCGA-CV-7252-01A-11D-2012-08	10864848	34596243	28429277	243	44123											
DLGAP4	22839	broad.mit.edu	37	chr20	35075135	35075135	+	Frame_Shift_Del	DEL	G	-	-																															ctgagtgaccagtatgaggcGgcctgcgagtcagcctgcag																								rs112014857		TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr20:35075135delG	uc002xff.2	+	7	1878	c.1443delG	c.(1441-1443)GCGfs	p.A481fs	DLGAP4_uc010zvp.1_Frame_Shift_Del_p.A481fs	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	481					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				AGTATGAGGCGGCCTGCGAGT	0.632													---	---	---								-	35075135	-	-	35075135	7	5	240	1	0	1	0	1	0	0	0	0	4584	1103	39	0	1461	0	DLGAP4	20	35075135	Frame_Shift_Del	DEL	G	TCGA-CV-7252-01A-11D-2012-08	478892	35075135	27950385	244	44124											
CHD6	84181	broad.mit.edu	37	chr20	40049688	40049688	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcctcctcatcactgtGgttctgactcaaaatcaatt	9	16	4	12	0	6	1	4	1	2	0	8	1	8	1	2	1	0	1	2	1	3	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr20:40049688G>A	uc002xka.1	-	31	5765	c.5587C>T	c.(5587-5589)CAC>TAC	p.H1863Y		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1863					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				tcatcACTGTGGTTCTGACTC	0.333													20	72					0	0	0	0	A	40049688	A	A	40049688	3	1	240	1	0	0	0	0	1	0	0	0	3344	1348	47	4	2588	4	CHD6	20	40049688	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	4974553	40049688	22975832	245	44125											
C20orf165	128497	broad.mit.edu	37	chr20	44515635	44515635	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagggcagcccctggcttGtggcattgccagggctgggc	4	7	16	14	0	0	0	0	0	0	0	0	0	0	0	4	5	2	4	4	5	0	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr20:44515635G>A	uc002xqf.2	-	2	214	c.205C>T	c.(205-207)CAA>TAA	p.Q69*		NM_080608	NP_542175	Q9BR10	CT165_HUMAN	chromosome 20 open reading frame 165	69						integral to membrane					0		Myeloproliferative disorder(115;0.0122)				CCCCTGGCTTGTGGCATTGCC	0.637													45	170					0	0	0	0	A	44515635	A	A	44515635	4	1	240	1	0	0	0	0	0	1	0	0	2104	1386	48	4	482	4	C20orf165	20	44515635	Nonsense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	4465947	44515635	18509885	246	44126											
GNAS	2778	broad.mit.edu	37	chr20	57429461	57429461	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctctccggggtacggatccCctgccgccggggcagcctca	4	6	13	18	4	2	0	1	0	1	0	4	1	3	1	7	5	3	2	7	5	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr20:57429461C>G	uc002xzw.2	+	1	1426	c.1141C>G	c.(1141-1143)CCT>GCT	p.P381A	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GTACGGATCCCCTGCCGCCGG	0.682			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			3	5					0	0	0	0	G	57429461	G	G	57429461	3	3	240	1	0	0	0	0	1	0	0	0	6547	623	22	4	1885	4	GNAS	20	57429461	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	12913826	57429461	5596059	247	44127											
SLC17A9	63910	broad.mit.edu	37	chr20	61598820	61598820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtttggacaggctcagaggGtggacctgagctctacccat	8	10	13	10	0	2	2	1	1	1	1	2	4	2	4	2	4	2	3	2	4	1	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr20:61598820G>A	uc002yea.3	+	13	1463	c.1279G>A	c.(1279-1281)GTG>ATG	p.V427M	SLC17A9_uc002ydz.3_Missense_Mutation_p.V421M|SLC17A9_uc011aap.1_3'UTR	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	427					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						GGCTCAGAGGGTGGACCTGAG	0.617													33	117					0	0	0	0	A	61598820	A	A	61598820	3	1	240	1	0	0	0	0	1	0	0	0	14489	1261	44	4	1329	4	SLC17A9	20	61598820	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	4169359	61598820	1426700	248	44128											
C20orf135	140701	broad.mit.edu	37	chr20	62493551	62493551	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccttccctcagcacgacGccaacgccatggacgtggtg	7	7	11	16	4	1	0	1	0	0	0	2	2	2	1	4	2	3	1	4	2	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr20:62493551G>A	uc002ygx.1	+	1	986	c.658G>A	c.(658-660)GCC>ACC	p.A220T		NM_080622	NP_542189	Q9H3Z7	ABHGB_HUMAN	hypothetical protein LOC140701	220							hydrolase activity				0	all_cancers(38;1.77e-12)|all_epithelial(29;3.12e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					TCAGCACGACGCCAACGCCAT	0.692													12	20					0	0	0	0	A	62493551	A	A	62493551	3	1	240	1	0	0	0	0	1	0	0	0	2098	1087	38	1	660	1	C20orf135	20	62493551	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	894731	62493551	531969	249	44129											
BAGE2	85319	broad.mit.edu	37	chr21	11058282	11058282	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggtacatttctcttcacaGcatttgatagtggctccaaa	10	14	8	9	0	2	1	1	1	1	0	4	1	3	1	1	2	2	3	1	2	3	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	3ca6c16c-0424-4e47-82d0-9e25e253944b	g.chr21:11058282G>A	uc002yit.1	-	3	366	c.158C>T	c.(157-159)GCT>GTT	p.A53V	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCTCTTCACAGCATTTGATAG	0.403													5	178					0	0	0	0	A	11058282	A	A	11058282	3	1	240	1	0	0	0	0	1	0	0	0	1294	971	34	4	179	4	BAGE2	21	11058282	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08		11058282	37071613	250	44130											
LIPI	149998	broad.mit.edu	37	chr21	15561401	15561401	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aactcacagcaacttttctgGtgtttttaactgctctatta	10	17	5	9	0	3	0	1	0	2	0	3	0	3	0	0	1	5	3	0	1	5	7			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr21:15561401G>T	uc002yjm.2	-	2	459	c.449C>A	c.(448-450)ACC>AAC	p.T150N	LIPI_uc010gkw.1_Missense_Mutation_p.T83N	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	129					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		AACTTTTCTGGTGTTTTTAAC	0.328													9	61					7.48243e-07	2.52176e-06	1	0	T	15561401	T	T	15561401	3	4	240	1	0	0	0	0	1	0	0	0	8867	1261	44	4	1032	4	LIPI	21	15561401	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	4503119	15561401	32568494	251	44131											
RNF160	26046	broad.mit.edu	37	chr21	30318479	30318479	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaagtatcacctaccaactGaaaagaaaaatatcttcatg	19	10	4	8	0	3	2	2	1	1	1	3	2	3	2	2	0	2	1	2	0	10	5			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr21:30318479G>A	uc002ymr.2	-	20	3769	c.3756C>T	c.(3754-3756)TTC>TTT	p.F1252F		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1206							ligase activity|zinc ion binding				0						CCTACCAACTGAAAAGAAAAA	0.308													17	98					0	0	0	0	A	30318479	A	A	30318479	2	1	240	1	0	0	0	0	0	0	0	1	13520	1281	45	2		2	RNF160	21	30318479	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	14757078	30318479	17811416	252	44132											
SYNJ1	8867	broad.mit.edu	37	chr21	34011425	34011425	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcttcagtggttcaggaagGaaagttgaacctaaaaaacc	15	8	11	7	0	2	1	2	1	0	0	2	3	2	3	2	4	2	3	2	4	6	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr21:34011425G>A	uc002yqh.2	-	31	3825	c.3825C>T	c.(3823-3825)TTC>TTT	p.F1275F	SYNJ1_uc011ads.1_Silent_p.F1189F|SYNJ1_uc002yqf.2_Silent_p.F1220F|SYNJ1_uc002yqg.2_Silent_p.F1189F|SYNJ1_uc002yqi.2_Silent_p.F1275F|SYNJ1_uc002yqe.3_5'UTR	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1236	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						GTTCAGGAAGGAAAGTTGAAC	0.453													22	88					0	0	0	0	A	34011425	A	A	34011425	2	1	240	1	0	0	0	0	0	0	0	1	15518	1165	41	2		2	SYNJ1	21	34011425	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	3692946	34011425	14118470	253	44133											
AIFM3	150209	broad.mit.edu	37	chr22	21332000	21332000	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgtcaggtgcagtgcccGccacaggcttcctgaggcaa	7	8	12	14	1	1	1	1	1	0	0	3	1	3	1	4	3	2	3	4	3	1	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr22:21332000G>A	uc002ztj.2	+	15	1512	c.1294G>A	c.(1294-1296)GCC>ACC	p.A432T	AIFM3_uc002ztk.2_Missense_Mutation_p.A432T|AIFM3_uc002ztl.2_Missense_Mutation_p.A438T|AIFM3_uc011ahx.1_Missense_Mutation_p.A420T|AIFM3_uc002ztm.1_Missense_Mutation_p.A244T|LZTR1_uc002ztn.2_5'Flank	NM_144704	NP_653305	Q96NN9	AIFM3_HUMAN	apoptosis-inducing factor,	432					activation of caspase activity by cytochrome c|cell redox homeostasis|electron transport chain|induction of apoptosis|mitochondrial depolarization|transport	endoplasmic reticulum|mitochondrial inner membrane	2 iron, 2 sulfur cluster binding|caspase activator activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity|protein binding			ovary(2)|lung(2)	4	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGCAGTGCCCGCCACAGGCTT	0.617													25	53					0	0	0	0	A	21332000	A	A	21332000	3	1	240	1	0	0	0	0	1	0	0	0	428	1087	38	1	1366	1	AIFM3	22	21332000	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08		21332000	29972566	254	44134											
KCNJ4	3761	broad.mit.edu	37	chr22	38823608	38823608	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcgcccgcttcttgggcCgcgccatcttggccatgatg	3	11	12	15	4	3	1	0	1	3	0	3	1	3	1	4	2	1	1	4	2	0	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chr22:38823608C>T	uc003avs.1	-	2	627	c.530G>A	c.(529-531)CGG>CAG	p.R177Q	KCNJ4_uc003avt.1_Missense_Mutation_p.R177Q	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	177	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					CTTCTTGGGCCGCGCCATCTT	0.642													8	51					0	0	0	0	T	38823608	T	T	38823608	3	4	240	1	0	0	0	0	1	0	0	0	8092	652	23	1	811	1	KCNJ4	22	38823608	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	17491608	38823608	12480958	255	44135											
NHS	4810	broad.mit.edu	37	chrX	17744773	17744773	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggaaaccaaaggcaaagccGaccccacctaaacgtagctc	16	3	8	14	2	0	0	0	0	0	0	1	2	0	1	5	2	4	3	5	2	6	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:17744773G>A	uc004cxx.2	+	6	2822	c.2484G>A	c.(2482-2484)CCG>CCA	p.P828P	NHS_uc011mix.1_Silent_p.P849P|NHS_uc004cxy.2_Silent_p.P672P|NHS_uc004cxz.2_Silent_p.P651P|NHS_uc004cya.2_Silent_p.P551P	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	828						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					AGGCAAAGCCGACCCCACCTA	0.502													29	141					0	0	0	0	A	17744773	A	A	17744773	2	1	240	1	0	0	0	0	0	0	0	1	10465	1045	37	1		1	NHS	23	17744773	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08		17744773	137525787	256	44136											
SRPX	8406	broad.mit.edu	37	chrX	38009042	38009042	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaaagtgtcaatcaggttGaacagggccacaggcatcac	14	6	12	9	0	3	1	3	1	0	0	3	2	3	2	1	4	1	2	1	4	4	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:38009042G>A	uc004ddy.1	-	10	1403	c.1317C>T	c.(1315-1317)TTC>TTT	p.F439F	SRPX_uc004ddz.1_Silent_p.F419F|SRPX_uc011mkh.1_Silent_p.F380F|SRPX_uc011mki.1_3'UTR	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	439					cell adhesion	cell surface|membrane					0						CAATCAGGTTGAACAGGGCCA	0.498													18	48					0	0	0	0	A	38009042	A	A	38009042	2	1	240	1	0	0	0	0	0	0	0	1	15230	1281	45	2		2	SRPX	23	38009042	Silent	SNP	G	TCGA-CV-7252-01A-11D-2012-08	20264269	38009042	117261518	257	44137											
MAOB	4129	broad.mit.edu	37	chrX	43652760	43652760	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctggtttctcatcattggCagagggggattgaagtgaat	10	13	13	5	0	3	3	2	2	2	1	4	4	3	4	0	4	0	2	0	4	2	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:43652760C>A	uc004dfz.3	-	8	1010	c.834G>T	c.(832-834)CTG>CTT	p.L278L	MAOB_uc011mkx.1_Silent_p.L262L|MAOB_uc011mky.1_Silent_p.L262L	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	278	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	TCATCATTGGCAGAGGGGGAT	0.413													24	63					1.42536e-11	4.9582e-11	1	0	A	43652760	A	A	43652760	2	1	240	1	0	0	0	0	0	0	0	1	9279	697	25	4		4	MAOB	23	43652760	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	5643718	43652760	111617800	258	44138											
TFE3	7030	broad.mit.edu	37	chrX	48891046	48891046	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgttaatgttgaatcgcctgCgacgctcaactttggagagg	9	11	12	9	4	1	2	1	1	0	1	2	4	1	2	1	2	2	3	1	2	3	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:48891046C>T	uc004dmb.3	-	8	1308	c.1070G>A	c.(1069-1071)CGC>CAC	p.R357H	TFE3_uc004dmc.3_Missense_Mutation_p.R252H|TFE3_uc004dme.1_RNA	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	357	Basic motif.				humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						GAATCGCCTGCGACGCTCAAC	0.532			T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								22	47					0	0	0	0	T	48891046	T	T	48891046	3	4	240	1	0	0	0	0	1	0	0	0	15866	768	27	1	669	1	TFE3	23	48891046	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	5238286	48891046	106379514	259	44139											
ZXDB	158586	broad.mit.edu	37	chrX	57618953	57618953	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactccggccccgatctccGcccccggccccgccgcggcc	2	3	10	26	7	1	0	0	0	1	0	3	1	2	0	11	3	0	0	11	3	0	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:57618953G>A	uc004dvd.2	+	1	685	c.472G>A	c.(472-474)GCC>ACC	p.A158T		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	158					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						cccgatctccgcccccggccc	0.463													6	15					0	0	0	0	A	57618953	A	A	57618953	3	1	240	1	0	0	0	0	1	0	0	0	18318	1087	38	1	474	1	ZXDB	23	57618953	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	8727907	57618953	97651607	260	44140											
EDA	1896	broad.mit.edu	37	chrX	69253319	69253320	+	Missense_Mutation	DNP	CG	AA	AA																															aggtgtttaagctacatcccCgcagcggggagctggaggta																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:69253319_69253320CG>AA	uc004dxs.2	+	7	1107_1108	c.865_866CG>AA	c.(865-867)CGC>AAC	p.R289N	EDA_uc004dxr.2_Missense_Mutation_p.R289N|EDA_uc011mpj.1_Missense_Mutation_p.R286N	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	289	Extracellular (Potential).				cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						GCTACATCCCCGCAGCGGGGAG	0.5											OREG0019847	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	149					0	0	0	0	AA	69253320	AA	AA	69253319	3	1	240	1	0	0	0	0	1	0	0	0	4925	652	23	3	1027	3	EDA	23	69253319	Missense_Mutation	DNP	CG	TCGA-CV-7252-01A-11D-2012-08	11634366	69253319	86017241	261	44141											
AWAT1	158833	broad.mit.edu	37	chrX	69458111	69458111	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactatctgctgagccatggCactggcaacctcgtgggcat	9	9	11	12	1	1	1	0	1	1	0	2	1	1	1	2	3	4	4	2	3	3	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:69458111C>A	uc004dxy.2	+	5	551	c.510C>A	c.(508-510)GGC>GGA	p.G170G		NM_001013579	NP_001013597	Q58HT5	AWAT1_HUMAN	wax synthase 1	170					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			ovary(3)	3						TGAGCCATGGCACTGGCAACC	0.542													30	76					2.85442e-18	1.0259e-17	1	0	A	69458111	A	A	69458111	2	1	240	1	0	0	0	0	0	0	0	1	1236	697	25	4		4	AWAT1	23	69458111	Silent	SNP	C	TCGA-CV-7252-01A-11D-2012-08	204792	69458111	85812449	262	44142											
RGAG4	340526	broad.mit.edu	37	chrX	71351044	71351044	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagaggggggtcagcgggcCcgtcgggggtgctgcgatcc	4	5	21	11	4	1	1	1	0	0	1	3	2	2	1	2	6	3	2	2	6	0	0			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:71351044C>T	uc010nlh.1	-	1	708	c.347G>A	c.(346-348)GGG>GAG	p.G116E	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA|NHSL2_uc004eak.1_5'Flank|NHSL2_uc010nli.2_5'Flank	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	116										ovary(2)|skin(1)	3	Renal(35;0.156)					GTCAGCGGGCCCGTCGGGGGT	0.697													6	12					0	0	0	0	T	71351044	T	T	71351044	3	4	240	1	0	0	0	0	1	0	0	0	13340	623	22	4	1366	4	RGAG4	23	71351044	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1892933	71351044	83919516	263	44143											
ATRX	546	broad.mit.edu	37	chrX	76920172	76920173	+	Frame_Shift_Ins	INS	-	T	T																															ttcattttgttttccagttcINStttttttcccttcttctggc																										TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:76920172_76920173insT	uc004ecp.3	-	11	4136_4137	c.3904_3905insA	c.(3904-3906)AGAfs	p.R1302fs	ATRX_uc004ecq.3_Frame_Shift_Ins_p.R1264fs|ATRX_uc004eco.3_Frame_Shift_Ins_p.R1087fs|ATRX_uc004ecr.2_Frame_Shift_Ins_p.R1234fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1302					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTTTCCAGTTCTTTTTTTCCCT	0.376			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						---	---	---								T	76920173	T	T	76920172	7	5	240	1	0	1	1	0	0	0	0	0	1210	913	32	0	3673	0	ATRX	23	76920172	Frame_Shift_Ins	INS	-	TCGA-CV-7252-01A-11D-2012-08	5569128	76920172	78350388	264	44144											
ATRX	546	broad.mit.edu	37	chrX	76937979	76937979	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctctgctctttcccagaaagCttatcgacaccatcagtgga	10	11	7	13	1	3	1	1	0	2	1	5	3	4	2	2	1	2	2	2	1	2	2			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:76937979C>A	uc004ecp.3	-	9	3001	c.2769G>T	c.(2767-2769)AAG>AAT	p.K923N	ATRX_uc004ecq.3_Missense_Mutation_p.K885N|ATRX_uc004eco.3_Missense_Mutation_p.K708N|ATRX_uc004ecr.2_Missense_Mutation_p.K855N|ATRX_uc010nlx.1_Missense_Mutation_p.K894N|ATRX_uc010nly.1_Missense_Mutation_p.K868N	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	923					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCCCAGAAAGCTTATCGACAC	0.398			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						41	230					4.32679e-17	1.5437e-16	1	0	A	76937979	A	A	76937979	3	1	240	1	0	0	0	0	1	0	0	0	1210	796	28	4	4817	4	ATRX	23	76937979	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	17807	76937979	78332581	265	44145											
ATG4A	115201	broad.mit.edu	37	chrX	107377334	107377334	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacccaaagaataccaacgcAtcctacagtgcttcttagat	15	9	5	12	1	1	2	0	0	1	2	2	2	2	2	3	0	5	2	3	0	7	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:107377334A>C	uc004enr.2	+	5	463	c.340A>C	c.(340-342)ATC>CTC	p.I114L	ATG4A_uc004ent.2_Missense_Mutation_p.I114L|ATG4A_uc004ens.2_Missense_Mutation_p.I30L|ATG4A_uc011msl.1_Missense_Mutation_p.I30L|ATG4A_uc010npi.2_RNA|ATG4A_uc004enu.2_Missense_Mutation_p.I30L	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	114					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1						ATACCAACGCATCCTACAGTG	0.348													14	21					0	0	0	0	C	107377334	C	C	107377334	3	2	240	1	0	0	0	0	1	0	0	0	1098	217	8	5	358	5	ATG4A	23	107377334	Missense_Mutation	SNP	A	TCGA-CV-7252-01A-11D-2012-08	30439355	107377334	47893226	266	44146											
GUCY2F	2986	broad.mit.edu	37	chrX	108708626	108708626	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcacattccaagagatgcatCtgagtctctcccccaatcaa	12	9	6	14	0	3	2	1	1	2	1	6	3	5	2	3	0	1	2	3	0	3	1			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:108708626C>G	uc004eod.3	-	3	1053	c.777G>C	c.(775-777)CAG>CAC	p.Q259H	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	259	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						AGAGATGCATCTGAGTCTCTC	0.413													44	127					0	0	0	0	G	108708626	G	G	108708626	3	3	240	1	0	0	0	0	1	0	0	0	6937	912	32	2	2617	2	GUCY2F	23	108708626	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	1331292	108708626	46561934	267	44147											
WDR44	54521	broad.mit.edu	37	chrX	117526618	117526618	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgaaagtattattgaggaGagtcagaaagtactacagct	16	11	10	4	0	1	4	1	2	0	2	1	5	1	4	0	1	3	3	0	1	6	6			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:117526618G>C	uc004eqn.2	+	4	635	c.210G>C	c.(208-210)GAG>GAC	p.E70D	WDR44_uc004eqo.2_Missense_Mutation_p.E70D|WDR44_uc011mtr.1_Missense_Mutation_p.E45D|WDR44_uc010nqi.2_5'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	70	Binding activity.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						TTATTGAGGAGAGTCAGAAAG	0.308													19	65					0	0	0	0	C	117526618	C	C	117526618	3	2	240	1	0	0	0	0	1	0	0	0	17364	933	33	2	224	2	WDR44	23	117526618	Missense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	8817992	117526618	37743942	268	44148											
THOC2	57187	broad.mit.edu	37	chrX	122767863	122767863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctccattgtcatttcctCtgtaatttctattcctgcca	6	19	4	12	0	3	0	1	0	2	0	6	0	6	0	4	0	2	2	4	0	2	7			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:122767863C>T	uc004etu.2	-	20	2109	c.2077G>A	c.(2077-2079)GAG>AAG	p.E693K	THOC2_uc011muh.1_Missense_Mutation_p.E618K	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	693					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						GTCATTTCCTCTGTAATTTCT	0.333													18	87					0	0	0	0	T	122767863	T	T	122767863	3	4	240	1	0	0	0	0	1	0	0	0	15931	922	32	2	2780	2	THOC2	23	122767863	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	5241245	122767863	32502697	269	44149											
L1CAM	3897	broad.mit.edu	37	chrX	153128177	153128177	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgagctgtcattgccccCtgccgcctccttctccttct	2	13	6	20	1	3	1	1	1	2	0	5	1	4	1	7	0	3	1	7	0	0	3			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:153128177C>T	uc004fjb.2	-	28	3823	c.3715G>A	c.(3715-3717)GGG>AGG	p.G1239R	L1CAM_uc004fjc.2_Missense_Mutation_p.G1235R|L1CAM_uc010nuo.2_Missense_Mutation_p.G1230R	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	1239	Cytoplasmic (Potential).		G -> E.		axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCATTGCCCCCTGCCGCCTCC	0.602													22	67					0	0	0	0	T	153128177	T	T	153128177	3	4	240	1	0	0	0	0	1	0	0	0	8628	681	24	4	62	4	L1CAM	23	153128177	Missense_Mutation	SNP	C	TCGA-CV-7252-01A-11D-2012-08	30360314	153128177	2142383	270	44150											
MTCP1NB	100272147	broad.mit.edu	37	chrX	154292277	154292277	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatctcacaggcttgcttctGgcacggatccttctgcggca	6	12	10	13	2	3	0	1	0	3	0	5	1	4	1	1	4	2	4	1	4	1	4			TCGA-CV-7252-01A-11D-2012-08	TCGA-CV-7252-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9692c6b2-ce97-4c92-a0dd-f27d01a94e6e	129a2324-5efb-4d86-b7ee-5534e24cf638	g.chrX:154292277G>A	uc004fmy.2	-	2	611	c.22C>T	c.(22-24)CAG>TAG	p.Q8*		NM_001018024	NP_001018024	P56277	MTCNB_HUMAN	mature T-cell proliferation 1 neighbor	8					cell proliferation	mitochondrion				lung(1)	1						GCTTGCTTCTGGCACGGATCC	0.328													32	151					0	0	0	0	A	154292277	A	A	154292277	4	1	240	1	0	0	0	0	0	1	0	0	9969	1357	47	4	192	4	MTCP1NB	23	154292277	Nonsense_Mutation	SNP	G	TCGA-CV-7252-01A-11D-2012-08	1164100	154292277	978283	271	44151											
RER1	11079	broad.mit.edu	37	chr1	2330854	2330854	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctctttccttctctttcagGgttggtacattgtgacctat	5	19	7	10	0	3	1	1	1	2	0	6	1	4	1	2	2	1	2	2	2	2	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:2330854G>A	uc001aje.1	+	4	378	c.187G>A	c.(187-189)GGT>AGT	p.G63S	RER1_uc001ajf.1_Missense_Mutation_p.G63S	NM_007033	NP_008964	O15258	RER1_HUMAN	RER1 retention in endoplasmic reticulum 1	63	Helical; (Potential).				retrograde vesicle-mediated transport, Golgi to ER	integral to Golgi membrane					0	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.28e-37)|OV - Ovarian serous cystadenocarcinoma(86;8.29e-23)|GBM - Glioblastoma multiforme(42;4.71e-08)|Colorectal(212;4.73e-05)|COAD - Colon adenocarcinoma(227;0.00021)|Kidney(185;0.00116)|BRCA - Breast invasive adenocarcinoma(365;0.00459)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0182)|Lung(427;0.204)		TCTCTTTCAGGGTTGGTACAT	0.463													9	93					0	0	0	0	A	2330854	A	A	2330854	3	1	241	1	0	0	0	0	1	0	0	0	13295	1246	43	4	197	4	RER1	1	2330854	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08		2330854	246919767	1	44152											
C1orf63	57035	broad.mit.edu	37	chr1	25573139	25573139	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccggtaccgcgaaggagaccGgtagtatctcctggtgaacc	9	7	13	12	4	1	2	0	1	1	1	2	4	1	2	5	4	2	3	5	4	5	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:25573139G>A	uc001bjw.2	-	2	568	c.316C>T	c.(316-318)CGG>TGG	p.R106W		NM_020317	NP_064713	Q9BUV0	CA063_HUMAN	hypothetical protein LOC57035	106	Arg-rich.									pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.9e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000333)|BRCA - Breast invasive adenocarcinoma(304;0.000443)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000932)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GAAGGAGACCGGTAGTATCTC	0.672													8	67					0	0	0	0	A	25573139	A	A	25573139	3	1	241	1	0	0	0	0	1	0	0	0	2063	1115	39	1	572	1	C1orf63	1	25573139	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	23242285	25573139	223677482	2	44153											
TMEM57	55219	broad.mit.edu	37	chr1	25810763	25810763	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagaacgagctgctgcagaaCaagtacgtgcacctttcagg	12	7	12	10	2	1	2	1	0	0	2	1	4	1	2	1	1	7	5	1	1	4	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:25810763C>A	uc001bkk.2	+	7	1513	c.1311C>A	c.(1309-1311)AAC>AAA	p.N437K	TMEM57_uc009vru.2_Missense_Mutation_p.N210K|TMEM57_uc009vrv.2_Missense_Mutation_p.N79K	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	437						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTGCAGAACAAGTACGTGC	0.572													17	51					2.48551e-13	2.98261e-13	1	0	A	25810763	A	A	25810763	3	1	241	1	0	0	0	0	1	0	0	0	16250	477	17	4	1337	4	TMEM57	1	25810763	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	237624	25810763	223439858	3	44154											
ZNHIT6	54680	broad.mit.edu	37	chr1	86146537	86146537	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accttttttctatgtactcaGcttgactttgaggaaactgg	9	16	8	8	0	2	2	1	2	1	0	2	3	2	3	1	2	3	2	1	2	3	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:86146537G>T	uc001dlh.2	-	6	1204	c.1070C>A	c.(1069-1071)GCT>GAT	p.A357D	ZNHIT6_uc010osc.1_Missense_Mutation_p.A318D	NM_017953	NP_060423	Q9NWK9	BCD1_HUMAN	zinc finger, HIT type 6	357					box C/D snoRNP assembly|ribosome biogenesis	pre-snoRNP complex	identical protein binding|metal ion binding			large_intestine(1)	1						TATGTACTCAGCTTGACTTTG	0.308													5	19					0.00116845	0.0012457	1	0	T	86146537	T	T	86146537	3	4	241	1	0	0	0	0	1	0	0	0	18276	971	34	4	362	4	ZNHIT6	1	86146537	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	60335774	86146537	163104084	4	44155											
COL11A1	1301	broad.mit.edu	37	chr1	103364525	103364525	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttttcaccttgtcttcccTctgcacctgcagctccagga	5	14	6	16	0	3	0	1	0	2	0	5	1	5	1	4	1	3	3	4	1	0	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:103364525T>C	uc001dul.2	-	55	4430	c.4112A>G	c.(4111-4113)GAG>GGG	p.E1371G	COL11A1_uc001duk.2_Missense_Mutation_p.E567G|COL11A1_uc001dum.2_Missense_Mutation_p.E1383G|COL11A1_uc001dun.2_Missense_Mutation_p.E1332G|COL11A1_uc009weh.2_Missense_Mutation_p.E1255G	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1371	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTGTCTTCCCTCTGCACCTGC	0.269													7	10					0	0	0	0	C	103364525	C	C	103364525	3	2	241	1	0	0	0	0	1	0	0	0	3682	1551	54	5	1360	5	COL11A1	1	103364525	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	17217988	103364525	145886096	5	44156											
CELSR2	1952	broad.mit.edu	37	chr1	109795741	109795743	+	In_Frame_Del	DEL	CTT	-	-																															ctacagtccacgtccgcctcCttgaccgcaatgacaaccca																								rs115856488	byFrequency	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:109795741_109795743delCTT	uc001dxa.3	+	1	3101_3103	c.3040_3042delCTT	c.(3040-3042)CTTdel	p.L1014del		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1014	Extracellular (Potential).|Cadherin 8.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CGTCCGCCTCCTTGACCGCAATG	0.581													---	---	---								-	109795743	-	-	109795741	7	5	241	1	0	1	0	1	0	0	0	0	3237	681	24	0	3042	0	CELSR2	1	109795741	In_Frame_Del	DEL	CTT	TCGA-CV-7253-01A-11D-2012-08	6431216	109795741	139454880	6	44157											
CEPT1	10390	broad.mit.edu	37	chr1	111726202	111726203	+	Frame_Shift_Del	DEL	TT	-	-																															tgaatatattgtactttggaTtgccctggtaagtattgtac																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:111726202_111726203delTT	uc001eah.1	+	8	1332_1333	c.1124_1125delTT	c.(1123-1125)ATTfs	p.I375fs	CEPT1_uc001eai.1_Frame_Shift_Del_p.I375fs|CEPT1_uc001eaj.1_Frame_Shift_Del_p.I375fs|CEPT1_uc009wfz.1_Frame_Shift_Del_p.I109fs	NM_001007794	NP_001007795	Q9Y6K0	CEPT1_HUMAN	choline/ethanolaminephosphotransferase	375	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding				0		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)	GTACTTTGGATTGCCCTGGTAA	0.361													---	---	---								-	111726203	-	-	111726202	7	5	241	1	0	1	0	1	0	0	0	0	3279	1493	52	0	1150	0	CEPT1	1	111726202	Frame_Shift_Del	DEL	TT	TCGA-CV-7253-01A-11D-2012-08	1930461	111726202	137524419	7	44158											
BCL9	607	broad.mit.edu	37	chr1	147091476	147091476	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatgatggtccatcagcaCgggcctcggggagtggtccg	7	7	16	11	3	1	1	1	1	0	0	4	3	3	2	3	5	1	1	3	5	0	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:147091476C>T	uc001epq.2	+	8	2255	c.1515C>T	c.(1513-1515)CAC>CAT	p.H505H	BCL9_uc010ozr.1_Silent_p.H431H	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	505	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					TCCATCAGCACGGGCCTCGGG	0.567			T	IGH@|IGL@	B-ALL								41	100					0	0	0	0	T	147091476	T	T	147091476	2	4	241	1	0	0	0	0	0	0	0	1	1383	535	19	1		1	BCL9	1	147091476	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	35365274	147091476	102159145	8	44159											
KPRP	448834	broad.mit.edu	37	chr1	152732519	152732519	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtagaatgcccagtccagaActatgtaccctgtccagctc	10	10	8	13	0	0	2	0	0	0	2	3	2	2	2	4	0	4	3	4	0	5	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:152732519A>T	uc001fal.1	+	2	513	c.455A>T	c.(454-456)AAC>ATC	p.N152I		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	152	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGTCCAGAACTATGTACCC	0.502													48	107					0	0	0	0	T	152732519	T	T	152732519	3	4	241	1	0	0	0	0	1	0	0	0	8475	43	2	5	457	5	KPRP	1	152732519	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	5641043	152732519	96518102	9	44160											
INTS3	65123	broad.mit.edu	37	chr1	153745728	153745728	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgaaaagggtcctctgcagtGggctctgacagtgactgagg	9	8	15	9	1	2	3	0	3	2	0	3	4	3	3	1	3	1	2	1	3	2	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:153745728G>A	uc009wom.2	+	31	3332	c.3111G>A	c.(3109-3111)GTG>GTA	p.V1037V	INTS3_uc001fct.2_Silent_p.V1037V|INTS3_uc001fcu.2_Silent_p.V729V|INTS3_uc001fcv.2_Silent_p.V831V|INTS3_uc010peb.1_Silent_p.V897V|INTS3_uc001fcw.2_Silent_p.V550V|INTS3_uc010pec.1_Silent_p.V550V|INTS3_uc001fcy.2_Silent_p.V400V|INTS3_uc001fcx.2_Silent_p.V334V	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	1038					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCTCTGCAGTGGGCTCTGACA	0.552													42	74					0	0	0	0	A	153745728	A	A	153745728	2	1	241	1	0	0	0	0	0	0	0	1	7818	1335	47	4		4	INTS3	1	153745728	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	1013209	153745728	95504893	10	44161											
ATP8B2	57198	broad.mit.edu	37	chr1	154316484	154316484	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcctggcccaggacagccGggaggacaggctggctagca	9	3	16	13	1	0	0	0	0	0	0	0	3	0	3	3	6	3	3	3	6	1	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:154316484G>T	uc001fex.2	+	18	1973	c.1973G>T	c.(1972-1974)CGG>CTG	p.R658L		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	644	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CAGGACAGCCGGGAGGACAGG	0.632													17	32					4.75885e-15	5.79143e-15	1	0	T	154316484	T	T	154316484	3	4	241	1	0	0	0	0	1	0	0	0	1197	1116	39	3	2173	3	ATP8B2	1	154316484	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	570756	154316484	94934137	11	44162											
KIAA0907	22889	broad.mit.edu	37	chr1	155895555	155895555	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaaataggagcagcctggaCcttccaccttctccttgaca	10	9	8	14	0	1	1	0	1	1	0	3	3	2	3	5	2	2	2	5	2	2	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:155895555C>A	uc001fmi.1	-	7	785	c.761G>T	c.(760-762)GGT>GTT	p.G254V	KIAA0907_uc001fmj.1_Missense_Mutation_p.G254V|KIAA0907_uc009wrk.1_Intron|KIAA0907_uc009wrl.1_RNA|KIAA0907_uc001fml.1_Missense_Mutation_p.G254V|KIAA0907_uc001fmm.2_3'UTR	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	254											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			GCAGCCTGGACCTTCCACCTT	0.458													18	44					2.94398e-08	3.40604e-08	1	0	A	155895555	A	A	155895555	3	1	241	1	0	0	0	0	1	0	0	0	8238	507	18	4	1115	4	KIAA0907	1	155895555	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	1579071	155895555	93355066	12	44163											
RHBG	57127	broad.mit.edu	37	chr1	156348086	156348086	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gactatccacacctttggtgCctacttcgggctcgtccttt	5	14	8	14	2	0	0	0	0	0	0	4	1	2	0	4	2	2	1	4	2	2	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:156348086C>T	uc010pho.1	+	4	607	c.569C>T	c.(568-570)GCC>GTC	p.A190V	RHBG_uc010phm.1_Intron|RHBG_uc010phn.1_RNA|RHBG_uc001fos.2_Missense_Mutation_p.A121V|RHBG_uc009wrz.2_Missense_Mutation_p.A158V|RHBG_uc001for.2_Missense_Mutation_p.A160V	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	190	Helical; (Potential).				transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					ACCTTTGGTGCCTACTTCGGG	0.642													7	161					0	0	0	0	T	156348086	T	T	156348086	3	4	241	1	0	0	0	0	1	0	0	0	13389	739	26	4	583	4	RHBG	1	156348086	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	452531	156348086	92902535	13	44164											
F11R	50848	broad.mit.edu	37	chr1	160969992	160969992	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttgctgaaggcacgggtgcTtttgggattcgtaggcatca	7	12	15	7	2	1	1	1	1	0	0	2	2	1	2	0	4	2	6	0	4	2	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:160969992T>A	uc009wtt.2	-	5	805	c.535A>T	c.(535-537)AGC>TGC	p.S179C	F11R_uc010pjv.1_Missense_Mutation_p.S130C|F11R_uc001fxe.3_Missense_Mutation_p.S179C|F11R_uc009wtu.2_Missense_Mutation_p.S179C|F11R_uc010pjw.1_Missense_Mutation_p.S183C|F11R_uc001fxf.3_Missense_Mutation_p.S179C	NM_016946	NP_058642	Q9Y624	JAM1_HUMAN	F11 receptor precursor	179	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				ovary(2)	2	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			GCACGGGTGCTTTTGGGATTC	0.512													45	62					0	0	0	0	A	160969992	A	A	160969992	3	1	241	1	0	0	0	0	1	0	0	0	5363	1609	56	5	388	5	F11R	1	160969992	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	4621906	160969992	88280629	14	44165											
TMCO1	54499	broad.mit.edu	37	chr1	165737484	165737484	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcttgtacttgtctgtcctGtaaaccaggacccaggttat	8	14	8	11	0	2	0	0	0	2	0	3	1	3	1	3	2	2	3	3	2	4	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:165737484G>A	uc001gdj.3	-	2	242	c.93C>T	c.(91-93)TAC>TAT	p.Y31Y	TMCO1_uc001gdl.3_Intron|TMCO1_uc001gdm.3_5'UTR|TMCO1_uc001gdk.3_Silent_p.Y19Y|TMCO1_uc001gdn.3_RNA|uc001gdo.2_5'Flank	NM_019026	NP_061899	Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1	31						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					TGTCTGTCCTGTAAACCAGGA	0.373													12	19					0	0	0	0	A	165737484	A	A	165737484	2	1	241	1	0	0	0	0	0	0	0	1	16061	1372	48	4		4	TMCO1	1	165737484	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	4767492	165737484	83513137	15	44166											
ILDR2	387597	broad.mit.edu	37	chr1	166892037	166892037	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggagctgagttctgagatgGtgttgttatctgcagggaca	8	12	16	5	0	2	2	0	2	2	1	2	5	2	4	0	3	2	5	0	3	1	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:166892037G>C	uc001gdx.1	-	8	1060	c.1004C>G	c.(1003-1005)ACC>AGC	p.T335S		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	335	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						TTCTGAGATGGTGTTGTTATC	0.478													32	72					0	0	0	0	C	166892037	C	C	166892037	3	2	241	1	0	0	0	0	1	0	0	0	7749	1261	44	4	927	4	ILDR2	1	166892037	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	1154553	166892037	82358584	16	44167											
ADCY10	55811	broad.mit.edu	37	chr1	167868789	167868789	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaaggcgcacatcgtccaCtgcctgaccaatcaccagaa	12	5	9	15	2	1	2	1	1	0	1	3	2	2	2	4	2	1	2	4	2	3	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:167868789C>T	uc001ger.2	-	6	812	c.514G>A	c.(514-516)GTG>ATG	p.V172M	ADCY10_uc009wvk.2_Missense_Mutation_p.V80M|ADCY10_uc010plj.1_Missense_Mutation_p.V19M|ADCY10_uc009wvl.2_Missense_Mutation_p.V171M|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	172	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						ACATCGTCCACTGCCTGACCA	0.507													17	36					0	0	0	0	T	167868789	T	T	167868789	3	4	241	1	0	0	0	0	1	0	0	0	293	565	20	4	4430	4	ADCY10	1	167868789	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	976752	167868789	81381832	17	44168											
TNR	7143	broad.mit.edu	37	chr1	175372692	175372692	+	Frame_Shift_Del	DEL	C	-	-																															agccttcgttgcagatgcagCcacaggactcaaagctaaag																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:175372692delC	uc001gkp.1	-	2	641	c.560delG	c.(559-561)GGCfs	p.G187fs	TNR_uc009wwu.1_Frame_Shift_Del_p.G187fs|TNR_uc010pmz.1_Frame_Shift_Del_p.G187fs	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	187	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GCAGATGCAGCCACAGGACTC	0.577													---	---	---								-	175372692	-	-	175372692	7	5	241	1	0	1	0	1	0	0	0	0	16404	739	26	0	3596	0	TNR	1	175372692	Frame_Shift_Del	DEL	C	TCGA-CV-7253-01A-11D-2012-08	7503903	175372692	73877929	18	44169											
GLT25D2	23127	broad.mit.edu	37	chr1	183923934	183923934	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctggatatttagggacaaCtgagacatactgggagggtt	11	11	14	5	0	1	1	0	1	1	1	1	5	1	4	0	4	2	1	0	4	4	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:183923934C>G	uc001gqr.2	-	7	1363	c.991G>C	c.(991-993)GTT>CTT	p.V331L	GLT25D2_uc010poj.1_Missense_Mutation_p.V331L|GLT25D2_uc001gqq.2_Missense_Mutation_p.V68L|GLT25D2_uc001gqs.2_Missense_Mutation_p.V211L	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	331					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						TTAGGGACAACTGAGACATAC	0.448													24	30					0	0	0	0	G	183923934	G	G	183923934	3	3	241	1	0	0	0	0	1	0	0	0	6504	565	20	4	913	4	GLT25D2	1	183923934	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	8551242	183923934	65326687	19	44170											
PTGS2	5743	broad.mit.edu	37	chr1	186645174	186645174	+	Nonsense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagaaggggatgccagtgAtagagggtgttaaattcagc	12	8	16	5	0	1	3	1	1	0	2	1	4	1	4	1	4	2	2	1	4	4	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:186645174A>C	uc001gsb.2	-	8	1250	c.1113T>G	c.(1111-1113)TAT>TAG	p.Y371*	PTGS2_uc009wyo.2_Nonsense_Mutation_p.Y218*	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	371		For cyclooxygenase activity (By similarity).			cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GATGCCAGTGATAGAGGGTGT	0.383													42	57					0	0	0	0	C	186645174	C	C	186645174	4	2	241	1	0	0	0	0	0	1	0	0	12819	340	12	5	713	5	PTGS2	1	186645174	Nonsense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	2721240	186645174	62605447	20	44171											
CFH	3075	broad.mit.edu	37	chr1	196648779	196648779	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catgcaaatccccagatgttAtaaatggatctcctatatct	13	13	5	10	0	2	1	0	0	2	1	4	2	3	2	3	1	1	2	3	1	6	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:196648779A>G	uc001gtj.3	+	6	886	c.646A>G	c.(646-648)ATA>GTA	p.I216V	CFH_uc001gti.3_Missense_Mutation_p.I216V|CFH_uc009wyw.2_Missense_Mutation_p.I216V|CFH_uc009wyx.2_Missense_Mutation_p.I152V	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	216	Sushi 4.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CCCAGATGTTATAAATGGATC	0.299													6	17					0	0	0	0	G	196648779	G	G	196648779	3	3	241	1	0	0	0	0	1	0	0	0	3298	449	16	5	668	5	CFH	1	196648779	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	10003605	196648779	52601842	21	44172											
KIF21B	23046	broad.mit.edu	37	chr1	200978555	200978555	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caggacctggggctctcccgGggtaacagaggtacagatgt	9	7	15	10	1	1	2	0	0	1	2	2	3	1	3	2	6	2	3	2	6	2	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:200978555G>A	uc001gvs.1	-	2	420	c.103C>T	c.(103-105)CCG>TCG	p.P35S	KIF21B_uc001gvr.1_Missense_Mutation_p.P35S|KIF21B_uc009wzl.1_Missense_Mutation_p.P35S|KIF21B_uc010ppn.1_Missense_Mutation_p.P35S	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	35	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGCTCTCCCGGGGTAACAGAG	0.577													4	78					0	0	0	0	A	200978555	A	A	200978555	3	1	241	1	0	0	0	0	1	0	0	0	8328	1232	43	4	4903	4	KIF21B	1	200978555	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	4329776	200978555	48272066	22	44173											
IGFN1	91156	broad.mit.edu	37	chr1	201196111	201196111	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgctgccccagggctgcGagtgctgcatgagctgtgcc	5	8	14	14	1	0	1	0	1	0	0	0	2	0	1	4	1	7	5	4	1	0	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:201196111G>T	uc001gwc.2	+	12	3140	c.2368G>T	c.(2368-2370)GAG>TAG	p.E790*	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CCAGGGCTGCGAGTGCTGCAT	0.677													64	94					2.91325e-39	3.83479e-39	1	0	T	201196111	T	T	201196111	4	4	241	1	0	0	0	0	0	1	0	0	7629	1059	37	3	10974	3	IGFN1	1	201196111	Nonsense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	217556	201196111	48054510	23	44174											
ADORA1	134	broad.mit.edu	37	chr1	203134630	203134630	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgctgcccccgcttctcCtcatggtcctcatctacctg	3	12	9	17	1	4	0	2	0	2	0	6	0	5	0	5	2	3	2	5	2	1	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:203134630C>T	uc001gze.1	+	4	1016	c.583C>T	c.(583-585)CTC>TTC	p.L195F	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Missense_Mutation_p.L195F|ADORA1_uc010pqg.1_Missense_Mutation_p.L127F|ADORA1_uc009xak.1_Missense_Mutation_p.P120L|ADORA1_uc010pqh.1_Missense_Mutation_p.L228F	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	195	Helical; Name=5; (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	CCCGCTTCTCCTCATGGTCCT	0.552													23	76					0	0	0	0	T	203134630	T	T	203134630	3	4	241	1	0	0	0	0	1	0	0	0	326	681	24	4	589	4	ADORA1	1	203134630	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	1938519	203134630	46115991	24	44175											
PCNXL2	80003	broad.mit.edu	37	chr1	233397851	233397851	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggagctgcagcggaggggAggcgtggagaggtttcgact	7	7	20	7	3	0	1	0	0	0	1	1	6	0	4	0	7	3	3	0	7	0	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:233397851A>G	uc001hvl.2	-	3	655	c.420T>C	c.(418-420)CCT>CCC	p.P140P	PCNXL2_uc009xfu.2_5'Flank|PCNXL2_uc009xfv.1_5'Flank	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	140						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				AGCGGAGGGGAGGCGTGGAGA	0.488													3	137					0	0	0	0	G	233397851	G	G	233397851	2	3	241	1	0	0	0	0	0	0	0	1	11646	291	11	5		5	PCNXL2	1	233397851	Silent	SNP	A	TCGA-CV-7253-01A-11D-2012-08	30263221	233397851	15852770	25	44176											
RGS7	6000	broad.mit.edu	37	chr1	241032090	241032090	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcactttgcttgtgcttcTgcttgcatgaaaatgaactc	9	15	7	10	0	2	2	1	2	1	0	3	2	2	2	0	0	5	4	0	0	3	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr1:241032090T>A	uc001hyv.2	-	8	843	c.513A>T	c.(511-513)GCA>GCT	p.A171A	RGS7_uc010pyh.1_Silent_p.A145A|RGS7_uc010pyj.1_Silent_p.A87A|RGS7_uc001hyu.2_Silent_p.A171A|RGS7_uc009xgn.1_Silent_p.A118A|RGS7_uc001hyw.2_Silent_p.A171A|RGS7_uc001hyt.2_Silent_p.A3A	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	171					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CTTGTGCTTCTGCTTGCATGA	0.448													12	145					0	0	0	0	A	241032090	A	A	241032090	2	1	241	1	0	0	0	0	0	0	0	1	13375	1567	55	5		5	RGS7	1	241032090	Silent	SNP	T	TCGA-CV-7253-01A-11D-2012-08	7634239	241032090	8218531	26	44177											
WDR35	57539	broad.mit.edu	37	chr2	20138033	20138033	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttttttaaataccaaagtcGggggtgtggattgtcctcta	9	16	10	6	1	1	0	0	0	1	0	3	1	2	1	2	3	1	0	2	3	5	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:20138033G>A	uc002rdi.2	-	19	2197	c.2089C>T	c.(2089-2091)CGA>TGA	p.R697*	WDR35_uc002rdj.2_Nonsense_Mutation_p.R686*|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Nonsense_Mutation_p.R262*|WDR35_uc002rdk.3_Nonsense_Mutation_p.R262*	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	697										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACCAAAGTCGGGGGTGTGGA	0.438													22	122					0	0	0	0	A	20138033	A	A	20138033	4	1	241	1	0	0	0	0	0	1	0	0	17357	1124	39	1	1496	1	WDR35	2	20138033	Nonsense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08		20138033	223061340	27	44178											
C2orf16	84226	broad.mit.edu	37	chr2	27804830	27804830	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacagtccctctgagagaagCcatcacagtccctctgagag	11	7	9	14	0	3	3	1	2	2	2	5	5	5	3	3	0	1	0	3	0	1	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:27804830C>A	uc002rkz.3	+	1	5442	c.5391C>A	c.(5389-5391)AGC>AGA	p.S1797R	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1797	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.|21.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CTGAGAGAAGCCATCACAGTC	0.547													23	322					8.53417e-09	9.91809e-09	1	0	A	27804830	A	A	27804830	3	1	241	1	0	0	0	0	1	0	0	0	2167	738	26	4	5393	4	C2orf16	2	27804830	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	7666797	27804830	215394543	28	44179											
YPEL5	51646	broad.mit.edu	37	chr2	30379615	30379615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctcagaactcatctccaCtcgtttcacaggcgccactg	8	9	7	17	3	4	1	3	0	1	1	6	1	4	1	3	1	1	2	3	1	1	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:30379615C>T	uc002rna.3	+	4	659	c.98C>T	c.(97-99)ACT>ATT	p.T33I	YPEL5_uc002rnb.3_Missense_Mutation_p.T33I|YPEL5_uc002rnc.3_Missense_Mutation_p.T33I|YPEL5_uc002rmz.3_Missense_Mutation_p.T33I|YPEL5_uc010ezn.2_Intron|YPEL5_uc002rnd.2_Missense_Mutation_p.T33I	NM_001127401	NP_001120873	P62699	YPEL5_HUMAN	yippee-like 5	33							peptide-methionine-(S)-S-oxide reductase activity				0	Acute lymphoblastic leukemia(172;0.155)					CTCATCTCCACTCGTTTCACA	0.438													20	131					0	0	0	0	T	30379615	T	T	30379615	3	4	241	1	0	0	0	0	1	0	0	0	17561	565	20	4	100	4	YPEL5	2	30379615	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	2574785	30379615	212819758	29	44180											
LRPPRC	10128	broad.mit.edu	37	chr2	44145429	44145429	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggaacttcctggttacccTctctaaggatttctgctaat	9	14	7	11	1	2	0	0	0	2	0	4	2	3	2	2	3	3	2	2	3	4	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:44145429T>A	uc002rtr.2	-	28	3063	c.3005A>T	c.(3004-3006)GAG>GTG	p.E1002V	LRPPRC_uc010yob.1_Missense_Mutation_p.E902V	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	1002					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CTGGTTACCCTCTCTAAGGAT	0.368													14	43					0	0	0	0	A	44145429	A	A	44145429	3	1	241	1	0	0	0	0	1	0	0	0	9015	1551	54	5	1223	5	LRPPRC	2	44145429	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	13765814	44145429	199053944	30	44181											
CCDC85A	114800	broad.mit.edu	37	chr2	56419698	56419698	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaccggcagaaaggcaagagGgtgtctcgggagtggcagag	11	4	19	7	2	1	3	0	0	1	3	2	5	1	4	1	5	0	3	1	5	2	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:56419698G>A	uc002rzn.2	+	2	865	c.363G>A	c.(361-363)AGG>AGA	p.R121R		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	121										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AAGGCAAGAGGGTGTCTCGGG	0.542													18	60					0	0	0	0	A	56419698	A	A	56419698	2	1	241	1	0	0	0	0	0	0	0	1	2872	1223	43	4		4	CCDC85A	2	56419698	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	12274269	56419698	186779675	31	44182											
APLF	200558	broad.mit.edu	37	chr2	68772424	68772424	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgaccggcctgaatgtccCtatggaccatcctgttatag	9	11	10	11	1	0	2	0	2	0	0	2	4	2	3	5	2	0	1	5	2	4	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:68772424C>G	uc002sep.2	+	8	1439	c.1266C>G	c.(1264-1266)CCC>CCG	p.P422P	APLF_uc002seq.1_RNA|APLF_uc010fdf.2_Silent_p.P398P|APLF_uc002ser.1_Silent_p.P153P	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	422	PBZ-type 2.				double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						CTGAATGTCCCTATGGACCAT	0.423													6	47					0	0	0	0	G	68772424	G	G	68772424	2	3	241	1	0	0	0	0	0	0	0	1	776	668	24	4		4	APLF	2	68772424	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	12352726	68772424	174426949	32	44183											
ST3GAL5	8869	broad.mit.edu	37	chr2	86075251	86075251	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgctatacctgtgctcaaatAacagcgccattgatgtcttg	10	12	8	11	2	2	1	1	1	1	0	2	1	2	1	2	0	4	2	2	0	4	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:86075251A>T	uc002sqq.1	-	4	524	c.395T>A	c.(394-396)TTA>TAA	p.L132*	ST3GAL5_uc010fgq.1_Nonsense_Mutation_p.L4*|ST3GAL5_uc002sqp.1_Nonsense_Mutation_p.L109*	NM_003896	NP_003887	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	132	Lumenal (Potential).				ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity				0						GTGCTCAAATAACAGCGCCAT	0.483													135	222					0	0	0	0	T	86075251	T	T	86075251	4	4	241	1	0	0	0	0	0	1	0	0	15284	372	13	5	877	5	ST3GAL5	2	86075251	Nonsense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	17302827	86075251	157124122	33	44184											
MYO7B	4648	broad.mit.edu	37	chr2	128394185	128394185	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccgacatggggttctgctCatccaccccaagaccaaggt	11	7	9	14	1	2	1	1	0	1	1	3	2	3	1	5	3	2	2	5	3	3	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:128394185C>T	uc002top.2	+	45	6164	c.6111C>T	c.(6109-6111)CTC>CTT	p.L2037L	MYO7B_uc002tos.1_Silent_p.L147L|MYO7B_uc002tot.2_Silent_p.L147L	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	2037	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GGGTTCTGCTCATCCACCCCA	0.652													6	12					0	0	0	0	T	128394185	T	T	128394185	2	4	241	1	0	0	0	0	0	0	0	1	10136	813	29	2		2	MYO7B	2	128394185	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	42318934	128394185	114805188	34	44185											
FAM123C	205147	broad.mit.edu	37	chr2	131521973	131521973	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggaggaccagcccttgcaGctcagcacagaggctgtgga	9	6	15	11	0	1	1	1	0	0	1	1	4	1	4	2	4	4	4	2	4	0	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:131521973G>A	uc002trw.2	+	2	2518	c.2328G>A	c.(2326-2328)CAG>CAA	p.Q776Q	FAM123C_uc010fmv.2_Silent_p.Q776Q|FAM123C_uc010fms.1_Silent_p.Q776Q|FAM123C_uc010fmt.1_Silent_p.Q776Q|FAM123C_uc010fmu.1_Silent_p.Q776Q	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	776										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		AGCCCTTGCAGCTCAGCACAG	0.677													7	18					0	0	0	0	A	131521973	A	A	131521973	2	1	241	1	0	0	0	0	0	0	0	1	5452	962	34	4		4	FAM123C	2	131521973	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	3127788	131521973	111677400	35	44186											
LRP1B	53353	broad.mit.edu	37	chr2	141115638	141115638	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgcattttttattactacAagcaaactcatcctttttac	12	17	3	9	0	1	0	1	0	0	0	2	1	2	0	1	0	6	2	1	0	6	8			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:141115638A>C	uc002tvj.1	-	74	12277	c.11305T>G	c.(11305-11307)TGT>GGT	p.C3769G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3769	Extracellular (Potential).|LDL-receptor class A 32.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTATTACTACAAGCAAACTCA	0.388										TSP Lung(27;0.18)			26	45					0	0	0	0	C	141115638	C	C	141115638	3	2	241	1	0	0	0	0	1	0	0	0	9005	130	5	5	2566	5	LRP1B	2	141115638	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	9593665	141115638	102083735	36	44187											
NEB	4703	broad.mit.edu	37	chr2	152520126	152520126	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggcatcaggaagcatgttgTaggtatggatcacgttcctg	9	12	13	7	1	2	0	2	0	0	0	3	2	3	2	1	4	1	6	1	4	3	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:152520126T>C	uc010fnx.2	-	45	5890	c.5699A>G	c.(5698-5700)TAC>TGC	p.Y1900C		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1900	Nebulin 50.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AAGCATGTTGTAGGTATGGAT	0.483													8	35					0	0	0	0	C	152520126	C	C	152520126	3	2	241	1	0	0	0	0	1	0	0	0	10356	1638	57	5	20539	5	NEB	2	152520126	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	11404488	152520126	90679247	37	44188											
TANC1	85461	broad.mit.edu	37	chr2	160028631	160028631	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatgggtctttctctgcaGcctctgaccccactcaggat	8	11	9	13	0	4	1	1	1	3	0	5	3	4	2	3	2	2	1	3	2	1	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:160028631G>T	uc002uag.2	+	11	1626	c.1352_splice	c.e11-1	p.T451_splice	TANC1_uc010fol.1_Splice_Site_p.T345_splice|TANC1_uc010zcm.1_Splice_Site_p.T443_splice|TANC1_uc010fom.1_Splice_Site_p.T257_splice	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and							cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TTTCTCTGCAGCCTCTGACCC	0.438													27	52					7.26314e-15	8.79761e-15	1	0	T	160028631	T	T	160028631	5	4	241	1	0	0	0	0	0	0	1	0	15610	985	34	4	1385	4	TANC1	2	160028631	Splice_Site	SNP	G	TCGA-CV-7253-01A-11D-2012-08	7508505	160028631	83170742	38	44189											
TTN	7273	broad.mit.edu	37	chr2	179604400	179604400	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagattcaacttctggttcAgtaatgggttcaaccttctg	9	16	8	8	0	5	1	3	0	2	1	5	1	5	1	1	2	2	3	1	2	4	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:179604400A>G	uc010zfh.1	-	46	13271	c.13047T>C	c.(13045-13047)ACT>ACC	p.T4349T	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Silent_p.T4282T|TTN_uc010zfj.1_Silent_p.T4157T|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTGGTTCAGTAATGGGTT	0.393													40	106					0	0	0	0	G	179604400	G	G	179604400	2	3	241	1	0	0	0	0	0	0	0	1	16803	175	7	5		5	TTN	2	179604400	Silent	SNP	A	TCGA-CV-7253-01A-11D-2012-08	19575769	179604400	63594973	39	44190											
LOC200726	200726	broad.mit.edu	37	chr2	207509209	207509209	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctacctgaagtcatctgaGaacttgaagcatggagcact	13	10	9	9	0	3	3	1	3	2	1	3	5	3	4	1	1	4	2	1	1	4	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:207509209G>A	uc010fuh.1	+	2	424	c.249G>A	c.(247-249)GAG>GAA	p.E83E		NM_001102659	NP_001096129			hypothetical protein LOC200726												0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.115)|Lung(261;0.133)		AGTCATCTGAGAACTTGAAGC	0.493													10	25					0	0	0	0	A	207509209	A	A	207509209	2	1	241	1	0	0	0	0	0	0	0	1	8918	933	33	2		2	LOC200726	2	207509209	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	27904809	207509209	35690164	40	44191											
XRCC5	7520	broad.mit.edu	37	chr2	217002844	217002844	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgcagctgcctttcatggaAgacttgcggcaatacatgtt	9	12	11	9	1	1	1	1	0	0	1	1	2	1	2	1	2	5	4	1	2	3	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:217002844A>C	uc002vfy.2	+	12	1424	c.1284A>C	c.(1282-1284)GAA>GAC	p.E428D	XRCC5_uc002vfz.2_Missense_Mutation_p.E314D	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	428	Ku.				double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		CTTTCATGGAAGACTTGCGGC	0.368								Direct_reversal_of_damage|NHEJ					11	15					0	0	0	0	C	217002844	C	C	217002844	3	2	241	1	0	0	0	0	1	0	0	0	17524	69	3	5	1330	5	XRCC5	2	217002844	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	9493635	217002844	26196529	41	44192											
OBSL1	23363	broad.mit.edu	37	chr2	220417282	220417282	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcggatgcggacgcgggCtccgggtctcagcgggcggc	3	6	19	13	7	1	0	1	0	1	0	4	2	2	2	1	6	2	1	1	6	0	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:220417282C>T	uc010fwk.2	-	18	5341	c.5284G>A	c.(5284-5286)GCC>ACC	p.A1762T		NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1762					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CGGACGCGGGCTCCGGGTCTC	0.731													6	15					0	0	0	0	T	220417282	T	T	220417282	3	4	241	1	0	0	0	0	1	0	0	0	10867	797	28	4	422	4	OBSL1	2	220417282	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	3414438	220417282	22782091	42	44193											
OBSL1	23363	broad.mit.edu	37	chr2	220424011	220424011	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catacaaactcgcccccgtcCtcgggctgagcagcaggtag	9	6	11	15	3	0	1	0	1	0	0	3	1	1	1	3	2	4	4	3	2	3	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:220424011C>T	uc010fwk.2	-	9	3219	c.3162G>A	c.(3160-3162)GAG>GAA	p.E1054E	OBSL1_uc002vmh.1_Silent_p.E45E|OBSL1_uc010zli.1_Silent_p.E45E|OBSL1_uc010fwl.1_Silent_p.E529E	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1054	Ig-like 8.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CGCCCCCGTCCTCGGGCTGAG	0.617													31	109					0	0	0	0	T	220424011	T	T	220424011	2	4	241	1	0	0	0	0	0	0	0	1	10867	680	24	4		4	OBSL1	2	220424011	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	6729	220424011	22775362	43	44194											
SLC19A3	80704	broad.mit.edu	37	chr2	228563937	228563937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtaaaagtacgacatgttcGccagggataccaagagttga	14	8	12	7	2	0	2	0	1	0	1	1	4	0	3	2	2	2	4	2	2	5	5	rs144223086	byFrequency	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:228563937G>A	uc002vpi.2	-	3	583	c.494C>T	c.(493-495)GCG>GTG	p.A165V	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.A161V	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	165	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	CGACATGTTCGCCAGGGATAC	0.542													48	90					0	0	0	0	A	228563937	A	A	228563937	3	1	241	1	0	0	0	0	1	0	0	0	14495	1087	38	1	1012	1	SLC19A3	2	228563937	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	8139926	228563937	14635436	44	44195											
ALPI	248	broad.mit.edu	37	chr2	233321697	233321697	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggccaacttccagaccatcgGcttgagtgcagccgcccgct	7	7	11	16	3	0	2	0	1	0	1	2	2	1	2	5	2	3	3	5	2	1	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:233321697G>C	uc002vst.3	+	4	466	c.389G>C	c.(388-390)GGC>GCC	p.G130A	ALPI_uc002vsu.3_Missense_Mutation_p.G41A	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	130					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CAGACCATCGGCTTGAGTGCA	0.617													3	34					0	0	0	0	C	233321697	C	C	233321697	3	2	241	1	0	0	0	0	1	0	0	0	543	1203	42	4	403	4	ALPI	2	233321697	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	4757760	233321697	9877676	45	44196											
SH3BP4	23677	broad.mit.edu	37	chr2	235949783	235949783	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caacactgagtgacagcggtAtgattgataatcttccagac	13	10	9	9	1	1	5	0	4	1	1	2	5	2	5	1	1	2	1	1	1	3	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:235949783A>G	uc002vvp.2	+	4	763	c.370A>G	c.(370-372)ATG>GTG	p.M124V	SH3BP4_uc010fym.2_Missense_Mutation_p.M124V|SH3BP4_uc002vvq.2_Missense_Mutation_p.M124V	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	124					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		TGACAGCGGTATGATTGATAA	0.527													17	41					0	0	0	0	G	235949783	G	G	235949783	3	3	241	1	0	0	0	0	1	0	0	0	14311	449	16	5	376	5	SH3BP4	2	235949783	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	2628086	235949783	7249590	46	44197											
KIF1A	547	broad.mit.edu	37	chr2	241657475	241657475	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggcggccctaccgtatggtCccggccaggagggggttgaa	7	6	17	11	3	0	1	0	1	0	0	1	2	1	2	4	7	1	2	4	7	3	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr2:241657475C>T	uc002vzy.2	-	46	5168	c.5022G>A	c.(5020-5022)GGG>GGA	p.G1674G	KIF1A_uc010fzk.2_Silent_p.G1775G|KIF1A_uc002vzw.2_Silent_p.G335G|KIF1A_uc002vzx.2_Silent_p.G401G	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1674					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ACCGTATGGTCCCGGCCAGGA	0.667													4	14					0	0	0	0	T	241657475	T	T	241657475	2	4	241	1	0	0	0	0	0	0	0	1	8322	842	30	2		2	KIF1A	2	241657475	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	5707692	241657475	1541898	47	44198											
XYLB	9942	broad.mit.edu	37	chr3	38442394	38442394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccttctaggtcttgcaggtgGaacagatgtgcccttttcag	7	13	11	10	0	3	1	1	0	2	1	3	2	3	2	2	3	3	1	2	3	2	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:38442394G>A	uc003cic.2	+	18	1560	c.1451G>A	c.(1450-1452)GGA>GAA	p.G484E	XYLB_uc011ayp.1_Missense_Mutation_p.G347E|XYLB_uc003cid.1_Missense_Mutation_p.G406E	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	484					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		CTTGCAGGTGGAACAGATGTG	0.468													22	21					0	0	0	0	A	38442394	A	A	38442394	3	1	241	1	0	0	0	0	1	0	0	0	17530	1174	41	2	1521	2	XYLB	3	38442394	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08		38442394	159580036	48	44199											
AMIGO3	386724	broad.mit.edu	37	chr3	49756364	49756364	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtgggtggcgctcagacCgtgcaggtggtcgaaggaga	8	6	19	8	3	1	2	1	0	0	2	2	4	1	2	1	6	1	2	1	6	1	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:49756364C>T	uc003cxj.2	-	1	875	c.535G>A	c.(535-537)GGT>AGT	p.G179S	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	179	Extracellular (Potential).				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCGCTCAGACCGTGCAGGTGG	0.642											OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	29					0	0	0	0	T	49756364	T	T	49756364	3	4	241	1	0	0	0	0	1	0	0	0	577	652	23	1	983	1	AMIGO3	3	49756364	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	11313970	49756364	148266066	49	44200											
CACNA1D	776	broad.mit.edu	37	chr3	53842766	53842766	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccatcttcccccatcgcaCggccctgcctctgcatctaa	6	10	5	20	2	3	0	0	0	3	0	6	0	5	0	5	1	2	2	5	1	1	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:53842766C>T	uc003dgv.3	+	46	6003	c.5840C>T	c.(5839-5841)ACG>ATG	p.T1947M	CACNA1D_uc003dgu.3_Missense_Mutation_p.T1967M|CACNA1D_uc003dgy.3_Missense_Mutation_p.T1923M|CACNA1D_uc003dgw.3_Missense_Mutation_p.T1614M|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1947	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CCCCATCGCACGGCCCTGCCT	0.642													9	60					0	0	0	0	T	53842766	T	T	53842766	3	4	241	1	0	0	0	0	1	0	0	0	2553	536	19	1	6194	1	CACNA1D	3	53842766	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	4086402	53842766	144179664	50	44201											
MBNL1	4154	broad.mit.edu	37	chr3	152163264	152163264	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acatttgcaagccaagatcaAggctgcccaataccaggtca	14	7	8	12	0	2	1	2	0	0	1	2	1	2	1	3	2	4	2	3	2	5	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:152163264A>C	uc003ezm.2	+	4	1532	c.743A>C	c.(742-744)AAG>ACG	p.K248T	MBNL1_uc003ezh.2_Missense_Mutation_p.K248T|MBNL1_uc003ezi.2_Missense_Mutation_p.K248T|MBNL1_uc003ezj.2_Missense_Mutation_p.K191T|MBNL1_uc003ezl.2_Missense_Mutation_p.K248T|MBNL1_uc003ezp.2_Missense_Mutation_p.K248T|MBNL1_uc003ezn.2_Missense_Mutation_p.K180T|MBNL1_uc003ezo.2_Missense_Mutation_p.K180T|MBNL1_uc010hvp.2_Missense_Mutation_p.K156T	NM_207293	NP_997176	Q9NR56	MBNL1_HUMAN	muscleblind-like 1 isoform c	248					embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GCCAAGATCAAGGCTGCCCAA	0.512													137	138					0	0	0	0	C	152163264	C	C	152163264	3	2	241	1	0	0	0	0	1	0	0	0	9406	72	3	5	757	5	MBNL1	3	152163264	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	98320498	152163264	45859166	51	44202											
MECOM	2122	broad.mit.edu	37	chr3	168807903	168807903	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttcctgtttttccagtaaTatcattgtcttcatcctcct	6	20	3	12	0	3	0	2	0	1	0	7	0	7	0	4	0	0	2	4	0	2	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:168807903T>C	uc003ffi.3	-	14	2991	c.2722A>G	c.(2722-2724)ATT>GTT	p.I908V	MECOM_uc010hwk.1_Missense_Mutation_p.I922V|MECOM_uc003ffj.3_Missense_Mutation_p.I973V|MECOM_uc011bpi.1_Missense_Mutation_p.I900V|MECOM_uc003ffn.3_Missense_Mutation_p.I908V|MECOM_uc003ffk.2_Missense_Mutation_p.I899V|MECOM_uc003ffl.2_Missense_Mutation_p.I1059V|MECOM_uc011bpj.1_Missense_Mutation_p.I1096V|MECOM_uc011bpk.1_Missense_Mutation_p.I898V	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	908	Asp/Glu-rich (acidic).				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TTTCCAGTAATATCATTGTCT	0.408													35	199					0	0	0	0	C	168807903	C	C	168807903	3	2	241	1	0	0	0	0	1	0	0	0	9475	1406	49	5	445	5	MECOM	3	168807903	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	16644639	168807903	29214527	52	44203											
ADIPOQ	9370	broad.mit.edu	37	chr3	186571026	186571026	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggccgtgatggcagagatgGcacccctggtgagaagggtg	9	6	18	8	1	0	3	0	2	0	2	0	5	0	3	3	5	0	2	3	5	1	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:186571026G>A	uc003fra.2	+	2	263	c.179G>A	c.(178-180)GGC>GAC	p.G60D	ADIPOQ_uc010hyy.2_Missense_Mutation_p.G60D	NM_004797	NP_004788	Q15848	ADIPO_HUMAN	adiponectin precursor	60	Collagen-like.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			ovary(1)	1	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		GGCAGAGATGGCACCCCTGGT	0.567													9	52					0	0	0	0	A	186571026	A	A	186571026	3	1	241	1	0	0	0	0	1	0	0	0	317	1203	42	4	181	4	ADIPOQ	3	186571026	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	17763123	186571026	11451404	53	44204											
LRRC15	131578	broad.mit.edu	37	chr3	194081062	194081062	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgttgtggaagagaccaggGgagagcagtccaatctggtt	10	10	15	6	0	1	2	0	0	1	2	2	5	2	3	2	4	1	3	2	4	2	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr3:194081062G>A	uc003ftu.2	-	2	797	c.711C>T	c.(709-711)TCC>TCT	p.S237S	LRRC15_uc003ftt.2_Silent_p.S243S	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	237	Extracellular (Potential).|LRR 8.					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		AGAGACCAGGGGAGAGCAGTC	0.552													5	202					0	0	0	0	A	194081062	A	A	194081062	2	1	241	1	0	0	0	0	0	0	0	1	9020	1219	43	4		4	LRRC15	3	194081062	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	7510036	194081062	3941368	54	44205											
GRSF1	2926	broad.mit.edu	37	chr4	71698926	71698926	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atttcaattaaggcatcaccCcttcgtttcccatctctgtt	8	16	4	13	1	3	0	2	0	1	0	6	0	4	0	3	1	0	3	3	1	2	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:71698926C>T	uc010iia.1	-	3	662	c.579G>A	c.(577-579)AGG>AGA	p.R193R	GRSF1_uc011caz.1_Silent_p.R75R|GRSF1_uc003hfs.2_Silent_p.R31R	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	193	RRM 1.				mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			AGGCATCACCCCTTCGTTTCC	0.438													18	61					0	0	0	0	T	71698926	T	T	71698926	2	4	241	1	0	0	0	0	0	0	0	1	6848	622	22	4		4	GRSF1	4	71698926	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08		71698926	119455350	55	44206											
SLC4A4	8671	broad.mit.edu	37	chr4	72222834	72222834	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	catcaaaccaagaaatccaaCcttcggtccctggctgacat	13	8	6	14	1	1	2	1	1	0	1	4	2	3	2	4	2	2	1	4	2	4	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:72222834C>A	uc003hfy.2	+	6	777	c.660C>A	c.(658-660)AAC>AAA	p.N220K	SLC4A4_uc010iic.2_Missense_Mutation_p.N220K|SLC4A4_uc010iib.2_Missense_Mutation_p.N220K|SLC4A4_uc003hfz.2_Missense_Mutation_p.N220K|SLC4A4_uc003hgc.3_Missense_Mutation_p.N176K|SLC4A4_uc003hga.2_Missense_Mutation_p.N98K|SLC4A4_uc003hgb.3_Missense_Mutation_p.N176K	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	220	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AGAAATCCAACCTTCGGTCCC	0.483													23	88					4.72057e-08	5.43709e-08	1	0	A	72222834	A	A	72222834	3	1	241	1	0	0	0	0	1	0	0	0	14720	506	18	4	799	4	SLC4A4	4	72222834	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	523908	72222834	118931442	56	44207											
SHROOM3	57619	broad.mit.edu	37	chr4	77662554	77662554	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgctcagcctgtcggggccCgagctgaagcagttccagca	8	6	13	14	3	1	1	1	1	0	0	3	2	2	1	3	2	4	5	3	2	1	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:77662554C>T	uc011cbx.1	+	5	4181	c.3228C>T	c.(3226-3228)CCC>CCT	p.P1076P	SHROOM3_uc011cbz.1_Silent_p.P900P|SHROOM3_uc003hkf.1_Silent_p.P951P|SHROOM3_uc003hkg.2_Silent_p.P854P	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1076					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			TGTCGGGGCCCGAGCTGAAGC	0.692													10	9					0	0	0	0	T	77662554	T	T	77662554	2	4	241	1	0	0	0	0	0	0	0	1	14360	639	23	1		1	SHROOM3	4	77662554	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	5439720	77662554	113491722	57	44208											
NHEDC1	150159	broad.mit.edu	37	chr4	103912839	103912839	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggaagttttcatcctccaaAtgttcattttttgattctgt	8	20	6	7	0	3	1	2	1	1	0	5	2	5	2	2	1	0	2	2	1	2	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:103912839A>T	uc003hww.2	-	2	152	c.30T>A	c.(28-30)CAT>CAA	p.H10Q	NHEDC1_uc003hwu.2_Missense_Mutation_p.H10Q|NHEDC1_uc010ilm.2_5'UTR|NHEDC1_uc003hwv.2_RNA|NHEDC1_uc011cev.1_5'UTR	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	10						integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		CATCCTCCAAATGTTCATTTT	0.264													3	2					0	0	0	0	T	103912839	T	T	103912839	3	4	241	1	0	0	0	0	1	0	0	0	10454	98	4	5	1661	5	NHEDC1	4	103912839	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	26250285	103912839	87241437	58	44209											
PCDH18	54510	broad.mit.edu	37	chr4	138451312	138451312	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtagggaacagaatccAtgctaacgttggtatggatg	11	11	13	6	1	0	1	0	0	0	1	1	3	1	3	1	3	3	4	1	3	5	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr4:138451312A>C	uc003ihe.3	-	1	2318	c.1931T>G	c.(1930-1932)ATG>AGG	p.M644R	PCDH18_uc003ihf.3_Missense_Mutation_p.M637R|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.M424R|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	644	Cadherin 6.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					AACAGAATCCATGCTAACGTT	0.438													4	185					0	0	0	0	C	138451312	C	C	138451312	3	2	241	1	0	0	0	0	1	0	0	0	11567	217	8	5	1492	5	PCDH18	4	138451312	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	34538473	138451312	52702964	59	44210											
CMBL	134147	broad.mit.edu	37	chr5	10286575	10286580	+	In_Frame_Del	DEL	TTGTTT	-	-																															attttctgggcatgacactgTtgtttcagatacttcaagat																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:10286575_10286580delTTGTTT	uc003jes.2	-	4	803_808	c.352_357delAAACAA	c.(352-357)AAACAAdel	p.KQ118del		NM_138809	NP_620164	Q96DG6	CMBL_HUMAN	carboxymethylenebutenolidase	118_119						cytosol	hydrolase activity|protein binding			skin(1)	1						CATGACACTGTTGTTTCAGATACTTC	0.422													---	---	---								-	10286580	-	-	10286575	7	5	241	1	0	1	0	1	0	0	0	0	3591	1722	60	0	392	0	CMBL	5	10286575	In_Frame_Del	DEL	TTGTTT	TCGA-CV-7253-01A-11D-2012-08		10286575	170628685	60	44211											
CDH12	1010	broad.mit.edu	37	chr5	21975279	21975279	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttatcattaatatcctgcacTttgatgatgaattctgattc	11	18	5	7	0	2	4	1	4	1	0	4	4	3	4	1	0	1	1	1	0	4	6			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:21975279T>A	uc010iuc.2	-	3	905	c.447A>T	c.(445-447)AAA>AAT	p.K149N	CDH12_uc011cno.1_Missense_Mutation_p.K149N|CDH12_uc003jgk.2_Missense_Mutation_p.K149N	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	149	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TATCCTGCACTTTGATGATGA	0.423										HNSCC(59;0.17)			5	77					0	0	0	0	A	21975279	A	A	21975279	3	1	241	1	0	0	0	0	1	0	0	0	3113	1606	56	5	1977	5	CDH12	5	21975279	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	11688704	21975279	158939981	61	44212											
PRDM9	56979	broad.mit.edu	37	chr5	23522937	23522937	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgggtctgcactttggcccTtatgagggccgaattacaga	8	11	12	10	1	1	2	0	1	1	1	1	3	1	2	2	3	2	1	2	3	3	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:23522937T>C	uc003jgo.2	+	8	1007	c.825T>C	c.(823-825)CCT>CCC	p.P275P		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	275	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ACTTTGGCCCTTATGAGGGCC	0.557										HNSCC(3;0.000094)			3	84					0	0	0	0	C	23522937	C	C	23522937	2	2	241	1	0	0	0	0	0	0	0	1	12525	1596	56	5		5	PRDM9	5	23522937	Silent	SNP	T	TCGA-CV-7253-01A-11D-2012-08	1547658	23522937	157392323	62	44213											
ADAMTS12	81792	broad.mit.edu	37	chr5	33576945	33576945	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgccactgtttcccaccCaggtctccttctttggaggc	4	14	8	15	0	3	0	0	0	3	0	5	1	4	1	4	3	1	1	4	3	0	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:33576945C>T	uc003jia.1	-	19	3349	c.3186G>A	c.(3184-3186)CTG>CTA	p.L1062L	ADAMTS12_uc010iuq.1_Silent_p.L977L	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1062	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GTTTCCCACCCAGGTCTCCTT	0.547										HNSCC(64;0.19)			29	49					0	0	0	0	T	33576945	T	T	33576945	2	4	241	1	0	0	0	0	0	0	0	1	257	581	21	4		4	ADAMTS12	5	33576945	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	10054008	33576945	147338315	63	44214											
TTC23L	153657	broad.mit.edu	37	chr5	34880347	34880347	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgagcaacattgggctcagaGgattttgaaacactgagcac	13	8	11	9	1	1	3	1	2	0	1	1	5	1	4	0	2	4	3	0	2	2	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:34880347G>T	uc003jiu.2	+	9	1114	c.1011G>T	c.(1009-1011)GAG>GAT	p.E337D	TTC23L_uc010iut.1_3'UTR	NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	337							binding			central_nervous_system(1)	1						TGGGCTCAGAGGATTTTGAAA	0.348													12	31					1.08611e-07	1.23989e-07	1	0	T	34880347	T	T	34880347	3	4	241	1	0	0	0	0	1	0	0	0	16759	991	35	4	1041	4	TTC23L	5	34880347	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	1303402	34880347	146034913	64	44215											
ESM1	11082	broad.mit.edu	37	chr5	54277890	54277890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagaaggggaatttcaggCattttcccgtccccctgtca	9	10	11	11	1	2	1	2	0	0	1	4	3	4	3	3	4	0	1	3	4	3	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:54277890C>T	uc003jpk.2	-	2	455	c.386G>A	c.(385-387)TGC>TAC	p.C129Y	ESM1_uc010ivt.2_Intron	NM_007036	NP_008967	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1 isoform a	129					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			GAATTTCAGGCATTTTCCCGT	0.483													30	36					0	0	0	0	T	54277890	T	T	54277890	3	4	241	1	0	0	0	0	1	0	0	0	5276	710	25	4	176	4	ESM1	5	54277890	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	19397543	54277890	126637370	65	44216											
TMEM174	134288	broad.mit.edu	37	chr5	72469320	72469320	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgctgtcagttggggtgAcattcatcctgattgctgtg	5	15	12	9	0	2	2	2	2	0	0	4	2	4	2	2	2	2	3	2	2	0	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:72469320A>T	uc010izc.2	+	1	298	c.250A>T	c.(250-252)ACA>TCA	p.T84S		NM_153217	NP_694949	Q8WUU8	TM174_HUMAN	transmembrane protein 174	84	Helical; (Potential).					integral to membrane				ovary(1)	1		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		AGTTGGGGTGACATTCATCCT	0.532													46	85					0	0	0	0	T	72469320	T	T	72469320	3	4	241	1	0	0	0	0	1	0	0	0	16156	275	10	5	252	5	TMEM174	5	72469320	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	18191430	72469320	108445940	66	44217											
ARSK	153642	broad.mit.edu	37	chr5	94936601	94936601	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgagtggatactctttgttgCcgttatcatcagaaacattt	10	16	8	7	1	3	2	2	1	1	1	3	3	3	3	1	1	3	2	1	1	3	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:94936601C>T	uc003kld.2	+	7	1305	c.1147C>T	c.(1147-1149)CCG>TCG	p.P383S	ARSK_uc010jbg.2_Missense_Mutation_p.P224S|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	383						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		CTCTTTGTTGCCGTTATCATC	0.358													21	36					0	0	0	0	T	94936601	T	T	94936601	3	4	241	1	0	0	0	0	1	0	0	0	998	739	26	4	1173	4	ARSK	5	94936601	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	22467281	94936601	85978659	67	44218											
DMXL1	1657	broad.mit.edu	37	chr5	118445852	118445852	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatattttttttaggcagtcGtcttttaactggttccagct	8	19	7	7	1	1	0	0	0	1	0	3	0	2	0	1	2	2	3	1	2	4	8	rs141228194		TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:118445852G>A	uc003ksd.2	+	5	552	c.371G>A	c.(370-372)CGT>CAT	p.R124H	DMXL1_uc010jcl.1_Missense_Mutation_p.R124H|DMXL1_uc003ksc.1_Missense_Mutation_p.R124H	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	124	WD 1.									ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TTAGGCAGTCGTCTTTTAACT	0.284													7	17					0	0	0	0	A	118445852	A	A	118445852	3	1	241	1	0	0	0	0	1	0	0	0	4616	1145	40	1	389	1	DMXL1	5	118445852	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	23509251	118445852	62469408	68	44219											
ZNF608	57507	broad.mit.edu	37	chr5	124080411	124080411	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgaattcccctggggagcaGaggcctgaacagaagcaaat	13	6	13	9	0	0	4	0	2	0	2	1	5	1	5	3	3	3	2	3	3	4	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:124080411G>C	uc003ktq.1	-	1	395	c.272C>G	c.(271-273)TCT>TGT	p.S91C	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Missense_Mutation_p.S91C|ZNF608_uc003ktt.1_Missense_Mutation_p.S91C	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	91						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CTGGGGAGCAGAGGCCTGAAC	0.498													4	61					0	0	0	0	C	124080411	C	C	124080411	3	2	241	1	0	0	0	0	1	0	0	0	18101	942	33	2	4302	2	ZNF608	5	124080411	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	5634559	124080411	56834849	69	44220											
ADAMTS19	171019	broad.mit.edu	37	chr5	128983577	128983577	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggatcagcagtcgagagcgCaaatgtcctgggtaaactca	12	7	13	9	2	2	1	2	0	0	1	4	3	3	2	1	2	3	3	1	2	3	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:128983577C>T	uc003kvb.1	+	12	1974	c.1974C>T	c.(1972-1974)CGC>CGT	p.R658R	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	658	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GTCGAGAGCGCAAATGTCCTG	0.507													43	91					0	0	0	0	T	128983577	T	T	128983577	2	4	241	1	0	0	0	0	0	0	0	1	264	697	25	4		4	ADAMTS19	5	128983577	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	4903166	128983577	51931683	70	44221											
RAPGEF6	51735	broad.mit.edu	37	chr5	130897676	130897676	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttaaagttcttaccacaaTcatttctgaaggctctaata	13	15	4	9	0	4	1	1	1	3	0	4	1	4	1	1	1	1	2	1	1	7	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:130897676T>A	uc003kvn.1	-	5	552	c.346A>T	c.(346-348)ATT>TTT	p.I116F	RAPGEF6_uc003kvp.1_Missense_Mutation_p.I166F|RAPGEF6_uc003kvo.1_Missense_Mutation_p.I116F|RAPGEF6_uc010jdi.1_Missense_Mutation_p.I116F|RAPGEF6_uc010jdj.1_Missense_Mutation_p.I116F|RAPGEF6_uc003kvr.2_Missense_Mutation_p.I116F|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.I116F	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	116					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CTTACCACAATCATTTCTGAA	0.303													14	43					0	0	0	0	A	130897676	A	A	130897676	3	1	241	1	0	0	0	0	1	0	0	0	13113	1435	50	5	5041	5	RAPGEF6	5	130897676	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	1914099	130897676	50017584	71	44222											
PCDHB16	57717	broad.mit.edu	37	chr5	140564246	140564246	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgtcgctcttcctcttttcGgtgctcctgttcgtggcggt	0	17	11	13	5	2	0	0	0	2	0	8	0	4	0	2	3	1	3	2	3	0	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:140564246G>A	uc003liv.2	+	1	3267	c.2112G>A	c.(2110-2112)TCG>TCA	p.S704S	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	704	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTCTTTTCGGTGCTCCTGT	0.697													16	274					0	0	0	0	A	140564246	A	A	140564246	2	1	241	1	0	0	0	0	0	0	0	1	11595	1103	39	1		1	PCDHB16	5	140564246	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	9666570	140564246	40351014	72	44223											
GABRB2	2561	broad.mit.edu	37	chr5	160758103	160758103	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttcccggaggtgggtgttGattgtggtcattgtgaggac	5	14	17	5	1	1	2	1	2	0	0	2	4	2	4	1	5	0	2	1	5	0	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:160758103G>C	uc003lys.1	-	9	1082	c.864C>G	c.(862-864)ATC>ATG	p.I288M	GABRB2_uc011deh.1_Missense_Mutation_p.I127M|GABRB2_uc003lyr.1_Missense_Mutation_p.I288M|GABRB2_uc003lyt.1_Missense_Mutation_p.I288M|GABRB2_uc010jiu.1_Missense_Mutation_p.I225M	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	288	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGTGGGTGTTGATTGTGGTCA	0.428													46	81					0	0	0	0	C	160758103	C	C	160758103	3	2	241	1	0	0	0	0	1	0	0	0	6201	1280	45	2	686	2	GABRB2	5	160758103	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	20193857	160758103	20157157	73	44224											
NSD1	64324	broad.mit.edu	37	chr5	176638656	176638662	+	Frame_Shift_Del	DEL	AGTAAAG	-	-																															gaggtggggcagaagatcctAgtaaagaggatccccttcag																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr5:176638656_176638662delAGTAAAG	uc003mfr.3	+	5	3394_3400	c.3256_3262delAGTAAAG	c.(3256-3264)AGTAAAGAGfs	p.S1086fs	NSD1_uc003mft.3_Frame_Shift_Del_p.S817fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.S983fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.S734fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1086_1088					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGAAGATCCTAGTAAAGAGGATCCCCT	0.449			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---								-	176638662	-	-	176638656	7	5	241	1	0	1	0	1	0	0	0	0	10723	420	15	0	3270	0	NSD1	5	176638656	Frame_Shift_Del	DEL	AGTAAAG	TCGA-CV-7253-01A-11D-2012-08	15880553	176638656	4276604	74	44225											
GFOD1	54438	broad.mit.edu	37	chr6	13365330	13365330	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaccagcagctcctgctccGgggcgctgttgcgctgcccg	3	7	14	17	4	0	0	0	0	0	0	2	0	2	0	4	2	5	7	4	2	0	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:13365330G>A	uc003nat.1	-	2	1483	c.818C>T	c.(817-819)CCG>CTG	p.P273L	GFOD1_uc003nas.1_Missense_Mutation_p.P170L	NM_018988	NP_061861	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain	273						extracellular region	binding|oxidoreductase activity			ovary(2)	2	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			CTCCTGCTCCGGGGCGCTGTT	0.697													32	16					0	0	0	0	A	13365330	A	A	13365330	3	1	241	1	0	0	0	0	1	0	0	0	6380	1116	39	1	358	1	GFOD1	6	13365330	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08		13365330	157749737	75	44226											
TNXB	7148	broad.mit.edu	37	chr6	32041664	32041664	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggtcacatctgtcactgTcagctctcctaggcgtggct	5	11	13	12	1	5	0	3	0	2	0	6	0	5	0	1	4	1	2	1	4	1	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:32041664T>C	uc003nzl.2	-	12	4643	c.4441A>G	c.(4441-4443)ACA>GCA	p.T1481A		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1568	Fibronectin type-III 8.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTGTCACTGTCAGCTCTCCT	0.587													4	14					0	0	0	0	C	32041664	C	C	32041664	3	2	241	1	0	0	0	0	1	0	0	0	16412	1667	58	5	10404	5	TNXB	6	32041664	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	18676334	32041664	139073403	76	44227											
TCP11	6954	broad.mit.edu	37	chr6	35088707	35088707	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggctgcttattgaggagttCctggaatttagcccgttcat	8	14	11	8	1	1	1	1	1	0	0	2	3	2	3	2	3	2	4	2	3	3	6			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:35088707C>A	uc003okd.2	-	6	914	c.733G>T	c.(733-735)GAA>TAA	p.E245*	TCP11_uc003ojz.1_Nonsense_Mutation_p.E170*|TCP11_uc003oka.2_Nonsense_Mutation_p.E170*|TCP11_uc003okb.2_Nonsense_Mutation_p.E169*|TCP11_uc003okc.2_Nonsense_Mutation_p.E169*|TCP11_uc011dsu.1_Nonsense_Mutation_p.E227*|TCP11_uc011dsv.1_Nonsense_Mutation_p.E194*|TCP11_uc011dsw.1_Nonsense_Mutation_p.E199*	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	232					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						TTGAGGAGTTCCTGGAATTTA	0.443													94	276					1.40862e-40	1.86371e-40	1	0	A	35088707	A	A	35088707	4	1	241	1	0	0	0	0	0	1	0	0	15779	864	30	2	837	2	TCP11	6	35088707	Nonsense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	3047043	35088707	136026360	77	44228											
DNAH8	1769	broad.mit.edu	37	chr6	38843395	38843395	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcttctggaagggttaattcCctccaaagaagaaggcggtg	11	10	12	8	1	2	2	0	0	2	2	4	3	4	3	2	4	0	1	2	4	5	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:38843395C>T	uc003ooe.1	+	51	7598	c.6998C>T	c.(6997-6999)CCC>CTC	p.P2333L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GGGTTAATTCCCTCCAAAGAA	0.289													24	5					0	0	0	0	T	38843395	T	T	38843395	3	4	241	1	0	0	0	0	1	0	0	0	4629	623	22	4	7192	4	DNAH8	6	38843395	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	3754688	38843395	132271672	78	44229											
BYSL	705	broad.mit.edu	37	chr6	41899233	41899233	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgctgaatacaaacgactCaacttccatctctacatggc	12	11	6	12	1	2	1	1	1	1	0	4	2	3	1	1	1	5	2	1	1	5	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:41899233C>T	uc003orl.2	+	5	1140	c.804C>T	c.(802-804)CTC>CTT	p.L268L		NM_004053	NP_004044	Q13895	BYST_HUMAN	bystin	268					cell adhesion|female pregnancy|ribosome biogenesis	cytoplasm|nucleolus					0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000473)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ACAAACGACTCAACTTCCATC	0.522													31	80					0	0	0	0	T	41899233	T	T	41899233	2	4	241	1	0	0	0	0	0	0	0	1	1581	813	29	2		2	BYSL	6	41899233	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	3055838	41899233	129215834	79	44230											
C6orf153	88745	broad.mit.edu	37	chr6	42996851	42996851	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgagcagcgccagttggcacTagctgagaagttcaaggagc	11	7	14	9	1	1	2	1	2	0	1	1	4	1	3	1	2	4	5	1	2	3	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:42996851T>A	uc003otp.1	+	7	673	c.665T>A	c.(664-666)CTA>CAA	p.L222Q		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	222					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CAGTTGGCACTAGCTGAGAAG	0.483													192	285					0	0	0	0	A	42996851	A	A	42996851	3	1	241	1	0	0	0	0	1	0	0	0	2348	1522	53	5	691	5	C6orf153	6	42996851	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	1097618	42996851	128118216	80	44231											
RSPH9	221421	broad.mit.edu	37	chr6	43618143	43618143	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagagtggagcctcttgcccCctgccacagaggagatggtg	8	7	14	12	0	1	3	0	0	1	3	1	5	1	4	4	3	3	0	4	3	0	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:43618143C>A	uc003ovw.1	+	2	285	c.259C>A	c.(259-261)CCT>ACT	p.P87T	RSPH9_uc003ovx.1_Missense_Mutation_p.P87T	NM_152732	NP_689945	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog	87					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				upper_aerodigestive_tract(1)|skin(1)	2						CCTCTTGCCCCCTGCCACAGA	0.537									Kartagener_syndrome				14	81					0.000151284	0.000164689	1	0	A	43618143	A	A	43618143	3	1	241	1	0	0	0	0	1	0	0	0	13773	623	22	4	265	4	RSPH9	6	43618143	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	621292	43618143	127496924	81	44232											
HMGCLL1	54511	broad.mit.edu	37	chr6	55304315	55304315	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accttttgcataagggcagcCacctaatccggatactgcgg	10	9	10	12	2	0	0	0	0	0	0	1	1	1	1	4	3	4	2	4	3	3	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:55304315C>T	uc003pcn.2	-	9	1087	c.928G>A	c.(928-930)GGC>AGC	p.G310S	HMGCLL1_uc003pco.2_Missense_Mutation_p.G280S|HMGCLL1_uc010jzx.2_Missense_Mutation_p.G181S|HMGCLL1_uc011dxc.1_Missense_Mutation_p.G248S|HMGCLL1_uc011dxd.1_Missense_Mutation_p.G177S|HMGCLL1_uc011dxe.1_Missense_Mutation_p.G114S	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	310							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			TAAGGGCAGCCACCTAATCCG	0.428													38	41					0	0	0	0	T	55304315	T	T	55304315	3	4	241	1	0	0	0	0	1	0	0	0	7269	594	21	4	192	4	HMGCLL1	6	55304315	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	11686172	55304315	115810752	82	44233											
ZNF451	26036	broad.mit.edu	37	chr6	56997899	56997899	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattccgaagaggaggccacAcgtgggtgtctgggaaacca	11	6	14	10	2	1	1	0	0	1	1	2	4	2	3	3	4	1	0	3	4	2	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:56997899A>C	uc003pdm.1	+	6	708	c.484A>C	c.(484-486)ACG>CCG	p.T162P	ZNF451_uc003pdl.2_Missense_Mutation_p.T162P|ZNF451_uc003pdn.1_Missense_Mutation_p.T162P|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.T162P	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AGGAGGCCACACGTGGGTGTC	0.393													15	47					0	0	0	0	C	56997899	C	C	56997899	3	2	241	1	0	0	0	0	1	0	0	0	17989	159	6	5	506	5	ZNF451	6	56997899	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	1693584	56997899	114117168	83	44234											
MANEA	79694	broad.mit.edu	37	chr6	96053864	96053864	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggaatttacacatatttTgccacaaatggctttactta	13	15	6	7	0	0	0	0	0	0	0	0	2	0	1	1	2	3	1	1	2	6	8			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:96053864T>C	uc003poo.1	+	5	1112	c.972T>C	c.(970-972)TTT>TTC	p.F324F		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	324	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		ACACATATTTTGCCACAAATG	0.343													17	12					0	0	0	0	C	96053864	C	C	96053864	2	2	241	1	0	0	0	0	0	0	0	1	9274	1809	63	5		5	MANEA	6	96053864	Silent	SNP	T	TCGA-CV-7253-01A-11D-2012-08	39055965	96053864	75061203	84	44235											
USP45	85015	broad.mit.edu	37	chr6	99883592	99883592	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataatcattaccattaatagTtataatactctttcatagaa	17	16	2	6	0	3	1	2	0	1	1	3	1	3	1	1	0	2	1	1	0	9	9			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:99883592T>C	uc003ppx.2	-	18	2978	c.2445A>G	c.(2443-2445)TAA>TAG	p.*815*	USP45_uc003ppv.2_RNA|USP45_uc003ppw.2_Silent_p.*495*	NM_001080481	NP_001073950	Q70EL2	UBP45_HUMAN	ubiquitin specific peptidase 45	815					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|breast(1)	2		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)		CCATTAATAGTTATAATACTC	0.363													18	12					0	0	0	0	C	99883592	C	C	99883592	2	2	241	1	0	0	0	0	0	0	0	1	17144	1732	60	5		5	USP45	6	99883592	Silent	SNP	T	TCGA-CV-7253-01A-11D-2012-08	3829728	99883592	71231475	85	44236											
OSTM1	28962	broad.mit.edu	37	chr6	108395812	108395812	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccccagcggcagccacggcGgcaacgaacacctccgctgc	8	2	12	19	5	0	0	0	0	0	0	1	1	1	0	5	3	5	3	5	3	2	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:108395812G>T	uc003psd.2	-	1	130	c.44C>A	c.(43-45)CCG>CAG	p.P15Q		NM_014028	NP_054747	Q86WC4	OSTM1_HUMAN	osteopetrosis associated transmembrane protein 1	15						integral to membrane				central_nervous_system(1)	1		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0131)|Epithelial(106;0.0438)|OV - Ovarian serous cystadenocarcinoma(136;0.0571)|all cancers(137;0.0581)		CAGCCACGGCGGCAACGAACA	0.751													6	6					8.12818e-05	8.92371e-05	1	0	T	108395812	T	T	108395812	3	4	241	1	0	0	0	0	1	0	0	0	11352	1116	39	3	984	3	OSTM1	6	108395812	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	8512220	108395812	62719255	86	44237											
AKD1	221264	broad.mit.edu	37	chr6	109819090	109819090	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagctctgacagtgtcagtcTtttggggatcatgtcagcag	8	12	12	9	0	5	1	3	1	2	0	5	2	5	2	0	2	2	2	0	2	0	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:109819090T>C	uc003ptn.2	-	37	5202	c.5125A>G	c.(5125-5127)AGA>GGA	p.R1709G	AKD1_uc011eas.1_Missense_Mutation_p.R94G	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1709					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						AGTGTCAGTCTTTTGGGGATC	0.473													22	27					0	0	0	0	C	109819090	C	C	109819090	3	2	241	1	0	0	0	0	1	0	0	0	460	1617	56	5	630	5	AKD1	6	109819090	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	1423278	109819090	61295977	87	44238											
C6orf58	352999	broad.mit.edu	37	chr6	127911377	127911377	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caccacgaattcttcttaatActgatgtagcccctttcatc	10	14	4	13	1	3	1	1	1	2	0	4	2	3	1	3	0	2	1	3	0	4	6			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:127911377A>G	uc003qbh.2	+	5	832	c.820A>G	c.(820-822)ACT>GCT	p.T274A		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	274						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		TCTTCTTAATACTGATGTAGC	0.398													51	38					0	0	0	0	G	127911377	G	G	127911377	3	3	241	1	0	0	0	0	1	0	0	0	2377	391	14	5	838	5	C6orf58	6	127911377	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	18092287	127911377	43203690	88	44239											
RAET1G	353091	broad.mit.edu	37	chr6	150240749	150240749	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctctgtaagtatgtccaccaCctctctcagtactgggttct	7	14	7	13	0	4	0	1	0	3	0	6	0	5	0	3	1	1	4	3	1	3	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:150240749C>A	uc010kii.1	-	2	357	c.289G>T	c.(289-291)GTG>TTG	p.V97L	RAET1G_uc003qnm.2_RNA	NM_001001788	NP_001001788	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G precursor	97	MHC class I alpha-1 like.|Extracellular (Potential).				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		ATGTCCACCACCTCTCTCAGT	0.507													45	129					3.05275e-18	3.86083e-18	1	0	A	150240749	A	A	150240749	3	1	241	1	0	0	0	0	1	0	0	0	13065	507	18	4	731	4	RAET1G	6	150240749	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	22329372	150240749	20874318	89	44240											
SYNE1	23345	broad.mit.edu	37	chr6	152542128	152542128	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atctttgccaaagctgaagtAgggccttgctggactgtagc	9	11	12	9	0	1	1	0	1	1	0	1	2	1	2	2	2	4	4	2	2	4	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr6:152542128A>G	uc010kiw.2	-	119	22312	c.21710T>C	c.(21709-21711)CTA>CCA	p.L7237P	SYNE1_uc010kiv.2_Missense_Mutation_p.L1761P|SYNE1_uc003qos.3_Missense_Mutation_p.L1761P|SYNE1_uc003qot.3_Missense_Mutation_p.L7166P|SYNE1_uc003qou.3_Missense_Mutation_p.L7237P|SYNE1_uc003qor.3_Missense_Mutation_p.L137P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7237	HAT 10.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAGCTGAAGTAGGGCCTTGCT	0.478										HNSCC(10;0.0054)			24	40					0	0	0	0	G	152542128	G	G	152542128	3	3	241	1	0	0	0	0	1	0	0	0	15511	420	15	5	4868	5	SYNE1	6	152542128	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	2301379	152542128	18572939	90	44241											
ISPD	729920	broad.mit.edu	37	chr7	16415830	16415830	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatcagcagatggactgaCgacagtagatacaagaggtc	15	6	11	9	1	1	4	1	1	0	3	2	6	1	5	1	2	2	2	1	2	3	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:16415830C>T	uc010ktx.2	-	3	571	c.571G>A	c.(571-573)GTC>ATC	p.V191I	ISPD_uc010kty.2_Intron	NM_001101426	NP_001094896	A4D126	ISPD_HUMAN	notch1-induced protein isoform a	191					isoprenoid biosynthetic process		nucleotidyltransferase activity			ovary(1)	1						GATGGACTGACGACAGTAGAT	0.418										Multiple Myeloma(15;0.18)			13	24					0	0	0	0	T	16415830	T	T	16415830	3	4	241	1	0	0	0	0	1	0	0	0	7903	536	19	1	816	1	ISPD	7	16415830	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08		16415830	142722833	91	44242											
CCDC129	223075	broad.mit.edu	37	chr7	31682803	31682803	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggaaatgatcatactcaaGacaagttccttcatgttgac	13	12	7	9	0	3	3	3	2	0	1	4	4	4	4	1	1	1	2	1	1	4	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:31682803G>C	uc003tcj.1	+	11	2812	c.1819G>C	c.(1819-1821)GAC>CAC	p.D607H	CCDC129_uc011kad.1_Missense_Mutation_p.D617H|CCDC129_uc003tci.1_Missense_Mutation_p.D458H|CCDC129_uc011kae.1_Missense_Mutation_p.D633H|CCDC129_uc003tck.1_Missense_Mutation_p.D515H	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	607											0						TCATACTCAAGACAAGTTCCT	0.493													42	95					0	0	0	0	C	31682803	C	C	31682803	3	2	241	1	0	0	0	0	1	0	0	0	2776	942	33	2	1857	2	CCDC129	7	31682803	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	15266973	31682803	127455860	92	44243											
ZNF117	51351	broad.mit.edu	37	chr7	64438979	64438979	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctccagtatgaattttttTatggtcagtaagatttgaaa	12	17	7	5	0	2	3	1	2	1	1	3	3	2	3	1	1	0	2	1	1	5	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:64438979T>A	uc003ttr.2	-	4	2255	c.970A>T	c.(970-972)AAA>TAA	p.K324*		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	324	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				TGAATTTTTTTATGGTCAGTA	0.353													23	39					0	0	0	0	A	64438979	A	A	64438979	4	1	241	1	0	0	0	0	0	1	0	0	17784	1763	61	5	485	5	ZNF117	7	64438979	Nonsense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	32756176	64438979	94699684	93	44244											
AUTS2	26053	broad.mit.edu	37	chr7	69064922	69064922	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatggatttgccatgaccAgctttgtcacttttgaagcg	8	15	10	8	1	1	3	1	3	0	0	1	4	1	4	2	1	3	1	2	1	1	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:69064922A>C	uc003tvw.3	+	1	1026	c.283A>C	c.(283-285)AGC>CGC	p.S95R	AUTS2_uc003tvv.3_Missense_Mutation_p.S95R|AUTS2_uc003tvx.3_Missense_Mutation_p.S95R	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	95										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TGCCATGACCAGCTTTGTCAC	0.657													8	25					0	0	0	0	C	69064922	C	C	69064922	3	2	241	1	0	0	0	0	1	0	0	0	1227	188	7	5	285	5	AUTS2	7	69064922	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	4625943	69064922	90073741	94	44245											
CROT	54677	broad.mit.edu	37	chr7	87022283	87022283	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggaggaggtggaaattttGttctctcaacaagtctggtt	9	13	13	6	1	3	0	1	0	2	0	4	3	3	3	0	5	1	2	0	5	3	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:87022283G>T	uc003uit.2	+	17	1863	c.1618G>T	c.(1618-1620)GTT>TTT	p.V540F	CROT_uc003uiu.2_Missense_Mutation_p.V568F	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	540					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TGGAAATTTTGTTCTCTCAAC	0.383													44	62					1.41504e-22	1.80732e-22	1	0	T	87022283	T	T	87022283	3	4	241	1	0	0	0	0	1	0	0	0	3909	1377	48	4	1764	4	CROT	7	87022283	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	17957361	87022283	72116380	95	44246											
CUX1	1523	broad.mit.edu	37	chr7	101845472	101845472	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacggcatctgccagagaatCttcggggagaaggtaaggga	13	6	15	7	2	2	2	0	0	2	2	3	5	2	3	1	5	2	2	1	5	4	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:101845472C>A	uc003uyx.3	+	18	2933	c.2895C>A	c.(2893-2895)ATC>ATA	p.I965I	CUX1_uc003uys.3_Silent_p.I976I|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	965	CUT 2.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GCCAGAGAATCTTCGGGGAGA	0.562													10	94					0.000442599	0.000479793	1	0	A	101845472	A	A	101845472	2	1	241	1	0	0	0	0	0	0	0	1	4081	903	32	2		2	CUX1	7	101845472	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	14823189	101845472	57293191	96	44247											
RELN	5649	broad.mit.edu	37	chr7	103123326	103123326	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatagatactcacaggacgAcctccacatggtccaaagcc	14	7	7	13	1	1	1	1	0	0	1	3	3	3	2	4	2	2	0	4	2	4	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:103123326A>G	uc003vca.2	-	63	10434	c.10274T>C	c.(10273-10275)GTC>GCC	p.V3425A	RELN_uc010liz.2_Missense_Mutation_p.V3425A	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3425					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCACAGGACGACCTCCACATG	0.473													19	62					0	0	0	0	G	103123326	G	G	103123326	3	3	241	1	0	0	0	0	1	0	0	0	13285	275	10	5	120	5	RELN	7	103123326	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	1277854	103123326	56015337	97	44248											
RELN	5649	broad.mit.edu	37	chr7	103163863	103163863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttccctggatgcatctccCatggccactgcacatgtcta	7	12	8	14	0	2	0	0	0	2	0	4	1	3	1	3	2	2	3	3	2	1	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:103163863C>T	uc003vca.2	-	47	7625	c.7465G>A	c.(7465-7467)GGG>AGG	p.G2489R	RELN_uc010liz.2_Missense_Mutation_p.G2489R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2489	EGF-like 6.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATGCATCTCCCATGGCCACTG	0.458													42	63					0	0	0	0	T	103163863	T	T	103163863	3	4	241	1	0	0	0	0	1	0	0	0	13285	594	21	4	2993	4	RELN	7	103163863	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	40537	103163863	55974800	98	44249											
CPA5	93979	broad.mit.edu	37	chr7	130008281	130008281	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgggatcaccgtcgactgggCctatgacagtggcatcaagt	9	9	13	10	2	2	1	2	1	0	0	3	3	2	2	2	3	0	1	2	3	2	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:130008281C>G	uc010lmd.1	+	14	1774	c.1154C>G	c.(1153-1155)GCC>GGC	p.A385G	CPA5_uc003vps.2_Missense_Mutation_p.A385G|CPA5_uc003vpt.2_Missense_Mutation_p.P357A|CPA5_uc010lme.1_Missense_Mutation_p.A385G|CPA5_uc003vpu.1_Missense_Mutation_p.A385G|uc003vpv.1_RNA	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1	385					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)					GTCGACTGGGCCTATGACAGT	0.562													4	116					0	0	0	0	G	130008281	G	G	130008281	3	3	241	1	0	0	0	0	1	0	0	0	3808	739	26	4	1196	4	CPA5	7	130008281	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	26844418	130008281	29130382	99	44250											
WDR91	29062	broad.mit.edu	37	chr7	134878366	134878366	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatattgatttcacagagaTtcttcttggcttccgtgtca	8	17	8	8	1	4	3	2	2	2	1	5	4	5	3	1	1	0	1	1	1	1	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:134878366T>G	uc003vsp.2	-	10	1516	c.1454A>C	c.(1453-1455)AAT>ACT	p.N485T	WDR91_uc010lmq.2_Missense_Mutation_p.N74T|WDR91_uc010lmr.2_RNA	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	485	WD 2.									breast(2)|ovary(1)|skin(1)	4						TTCACAGAGATTCTTCTTGGC	0.572													9	24					0	0	0	0	G	134878366	G	G	134878366	3	3	241	1	0	0	0	0	1	0	0	0	17406	1493	52	5	813	5	WDR91	7	134878366	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	4870085	134878366	24260297	100	44251											
GSTK1	373156	broad.mit.edu	37	chr7	142961250	142961250	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcctcataacagggatcatGaaagacagtggtaggaaggg	15	6	14	6	0	2	2	2	1	0	1	2	4	2	4	1	4	2	1	1	4	4	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr7:142961250G>A	uc003wci.2	+	2	229	c.144G>A	c.(142-144)ATG>ATA	p.M48I	GSTK1_uc011ksy.1_Missense_Mutation_p.M48I|GSTK1_uc003wcj.2_Missense_Mutation_p.M48I|GSTK1_uc011ksz.1_Missense_Mutation_p.M48I	NM_015917	NP_057001	Q9Y2Q3	GSTK1_HUMAN	glutathione S-transferase kappa 1 isoform a	48						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity				0	Melanoma(164;0.059)				Glutathione(DB00143)	CAGGGATCATGAAAGACAGTG	0.567													16	22					0	0	0	0	A	142961250	A	A	142961250	3	1	241	1	0	0	0	0	1	0	0	0	6875	1290	45	2	150	2	GSTK1	7	142961250	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	8082884	142961250	16177413	101	44252											
CSMD1	64478	broad.mit.edu	37	chr8	3059180	3059180	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaagtctggcctgtgcatgGgttccatcaaataattctgc	10	12	10	9	0	3	1	1	0	2	1	4	1	4	1	2	2	2	2	2	2	3	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:3059180G>A	uc011kwk.1	-	32	5445	c.5055C>T	c.(5053-5055)ACC>ACT	p.T1685T	CSMD1_uc011kwj.1_Silent_p.T1077T|CSMD1_uc003wqe.2_Silent_p.T841T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1685	Extracellular (Potential).|CUB 10.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTGTGCATGGGTTCCATCAA	0.438													7	11					0	0	0	0	A	3059180	A	A	3059180	2	1	241	1	0	0	0	0	0	0	0	1	3961	1219	43	4		4	CSMD1	8	3059180	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08		3059180	143304842	102	44253											
CLDN23	137075	broad.mit.edu	37	chr8	8560453	8560453	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgctggcgctcagcttcgCgccctggtgcgacgagcgtt	3	9	14	15	7	1	0	1	0	0	0	3	2	1	0	1	2	3	4	1	2	0	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:8560453C>T	uc003wsi.2	+	1	788	c.545C>T	c.(544-546)GCG>GTG	p.A182V		NM_194284	NP_919260	Q96B33	CLD23_HUMAN	claudin 23	182	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)		CTCAGCTTCGCGCCCTGGTGC	0.726													13	15					0	0	0	0	T	8560453	T	T	8560453	3	4	241	1	0	0	0	0	1	0	0	0	3499	768	27	1	547	1	CLDN23	8	8560453	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	5501273	8560453	137803569	103	44254											
NEFM	4741	broad.mit.edu	37	chr8	24772151	24772151	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagctcgaaagccactcagAccagaatatgcaccaggccg	13	4	9	15	2	1	2	1	0	0	2	2	3	1	2	5	1	3	2	5	1	3	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:24772151A>G	uc003xed.3	+	1	878	c.845A>G	c.(844-846)GAC>GGC	p.D282G	NEFM_uc011lac.1_Missense_Mutation_p.D282G|NEFM_uc010lue.2_5'Flank|uc010luc.1_5'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	282	Rod.|Coil 2A.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		AGCCACTCAGACCAGAATATG	0.587													9	72					0	0	0	0	G	24772151	G	G	24772151	3	3	241	1	0	0	0	0	1	0	0	0	10370	275	10	5	847	5	NEFM	8	24772151	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	16211698	24772151	121591871	104	44255											
SCARA5	286133	broad.mit.edu	37	chr8	27779108	27779108	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcgcgagggagatgttcCgcagtgcgatggagtgctcc	6	10	15	10	4	0	1	0	0	0	1	3	5	2	2	2	2	2	3	2	2	0	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:27779108C>T	uc003xgj.2	-	4	1336	c.896G>A	c.(895-897)CGG>CAG	p.R299Q	SCARA5_uc010luz.2_Intron|SCARA5_uc003xgk.2_Missense_Mutation_p.R256Q|SCARA5_uc003xgl.2_Missense_Mutation_p.R299Q	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	299	Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		GGAGATGTTCCGCAGTGCGAT	0.537													10	37					0	0	0	0	T	27779108	T	T	27779108	3	4	241	1	0	0	0	0	1	0	0	0	13945	652	23	1	615	1	SCARA5	8	27779108	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	3006957	27779108	118584914	105	44256											
ZNF704	619279	broad.mit.edu	37	chr8	81553638	81553638	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggccttcttccagcggCaggcggtacaccacatgtct	7	8	12	14	2	2	0	0	0	2	0	3	0	3	0	3	5	2	3	3	5	1	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:81553638C>G	uc003yby.1	-	9	1434	c.1202G>C	c.(1201-1203)TGC>TCC	p.C401S		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	401						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			CTTCCAGCGGCAGGCGGTACA	0.627													4	19					0	0	0	0	G	81553638	G	G	81553638	3	3	241	1	0	0	0	0	1	0	0	0	18174	710	25	4	40	4	ZNF704	8	81553638	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	53774530	81553638	64810384	106	44257											
MATN2	4147	broad.mit.edu	37	chr8	99015907	99015907	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggatcaactactgtgcacTgaacaaaccgggctgtgagc	12	7	12	10	1	1	2	1	2	0	0	1	3	1	3	1	2	6	2	1	2	4	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:99015907T>A	uc003yic.2	+	8	1454	c.1223T>A	c.(1222-1224)CTG>CAG	p.L408Q	MATN2_uc003yib.1_Missense_Mutation_p.L408Q|MATN2_uc010mbh.1_Missense_Mutation_p.L367Q|MATN2_uc003yid.2_Missense_Mutation_p.L408Q|MATN2_uc003yie.1_Missense_Mutation_p.L408Q|MATN2_uc010mbi.1_Missense_Mutation_p.L241Q	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	408	EGF-like 5.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TACTGTGCACTGAACAAACCG	0.597													9	75					0	0	0	0	A	99015907	A	A	99015907	3	1	241	1	0	0	0	0	1	0	0	0	9387	1580	55	5	1249	5	MATN2	8	99015907	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	17462269	99015907	47348115	107	44258											
CSMD3	114788	broad.mit.edu	37	chr8	113657362	113657362	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatgggttacatcaacagTccatgtacaattcagagaat	14	11	7	9	0	2	1	2	0	0	1	4	2	4	1	2	1	3	2	2	1	5	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:113657362T>A	uc003ynu.2	-	20	3445	c.3286A>T	c.(3286-3288)ACT>TCT	p.T1096S	CSMD3_uc003yns.2_Missense_Mutation_p.T368S|CSMD3_uc003ynt.2_Missense_Mutation_p.T1056S|CSMD3_uc011lhx.1_Missense_Mutation_p.T992S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1096	Extracellular (Potential).|CUB 6.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACATCAACAGTCCATGTACAA	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	42					0	0	0	0	A	113657362	A	A	113657362	3	1	241	1	0	0	0	0	1	0	0	0	3963	1667	58	5	8045	5	CSMD3	8	113657362	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	14641455	113657362	32706660	108	44259											
TRPS1	7227	broad.mit.edu	37	chr8	116616583	116616584	+	Frame_Shift_Ins	INS	-	A	A																															tcggaagtcacagaactgacINSaattatagctcgttaccata																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:116616583_116616584insA	uc003ynz.2	-	3	2032_2033	c.1573_1574insT	c.(1573-1575)TGTfs	p.C525fs	TRPS1_uc011lhy.1_Frame_Shift_Ins_p.C529fs|TRPS1_uc003yny.2_Frame_Shift_Ins_p.C538fs|TRPS1_uc010mcy.2_Frame_Shift_Ins_p.C525fs	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	525					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			ACAGAACTGACAATTATAGCTC	0.46									Langer-Giedion_syndrome				---	---	---								A	116616584	A	A	116616583	7	5	241	1	0	1	1	0	0	0	0	0	16660	478	17	0	2287	0	TRPS1	8	116616583	Frame_Shift_Ins	INS	-	TCGA-CV-7253-01A-11D-2012-08	2959221	116616583	29747439	109	44260											
KCNK9	51305	broad.mit.edu	37	chr8	140631071	140631071	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagtagtaggcgtggaagaaGctccactcctcacactggga	11	8	12	10	1	1	1	1	0	0	1	3	3	3	3	2	3	1	3	2	3	5	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr8:140631071G>C	uc003yvf.1	-	2	619	c.555C>G	c.(553-555)AGC>AGG	p.S185R	KCNK9_uc003yvg.1_Missense_Mutation_p.S185R|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	185	Extracellular (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CGTGGAAGAAGCTCCACTCCT	0.592													19	41					0	0	0	0	C	140631071	C	C	140631071	3	2	241	1	0	0	0	0	1	0	0	0	8111	962	34	4	573	4	KCNK9	8	140631071	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	24014488	140631071	5732951	110	44261											
DNAI1	27019	broad.mit.edu	37	chr9	34506628	34506628	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcttccctgggtagatgActtcatgaagcagagccggg	9	9	12	11	1	2	4	1	2	1	2	3	4	3	4	3	2	2	2	3	2	2	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:34506628A>G	uc003zum.2	+	13	1260	c.1067A>G	c.(1066-1068)GAC>GGC	p.D356G		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	356					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		TGGGTAGATGACTTCATGAAG	0.607									Kartagener_syndrome				10	58					0	0	0	0	G	34506628	G	G	34506628	3	3	241	1	0	0	0	0	1	0	0	0	4631	275	10	5	1117	5	DNAI1	9	34506628	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08		34506628	106706803	111	44262											
VCP	7415	broad.mit.edu	37	chr9	35060329	35060329	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtcaaagatttctctgAcattggcctcagactcccca	9	12	6	14	0	3	3	2	1	1	2	5	3	4	3	4	1	0	0	4	1	1	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:35060329A>C	uc003zvy.2	-	13	2065	c.1676T>G	c.(1675-1677)GTC>GGC	p.V559G	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.V228G|VCP_uc010mki.1_Missense_Mutation_p.V514G	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	559					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GATTTCTCTGACATTGGCCTC	0.458													19	26					0	0	0	0	C	35060329	C	C	35060329	3	2	241	1	0	0	0	0	1	0	0	0	17208	275	10	5	764	5	VCP	9	35060329	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	553701	35060329	106153102	112	44263											
SHB	6461	broad.mit.edu	37	chr9	38016101	38016101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atcattcttggcatcaaaggGatctgagtagtcatcggcta	11	12	10	8	1	5	1	3	1	2	0	6	2	5	2	0	3	0	3	0	3	3	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:38016101G>A	uc004aax.2	-	2	1313	c.745C>T	c.(745-747)CCC>TCC	p.P249S		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	249	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GCATCAAAGGGATCTGAGTAG	0.502													40	73					0	0	0	0	A	38016101	A	A	38016101	3	1	241	1	0	0	0	0	1	0	0	0	14333	1174	41	2	804	2	SHB	9	38016101	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	2955772	38016101	103197330	113	44264											
TMEM2	23670	broad.mit.edu	37	chr9	74319658	74319658	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagcaccatagggttggacGgatactcatctcgtgtaatg	10	10	13	8	2	2	0	1	0	1	0	3	3	2	3	1	4	2	3	1	4	3	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:74319658G>A	uc011lsa.1	-	18	3587	c.3047C>T	c.(3046-3048)CCG>CTG	p.P1016L	TMEM2_uc011lrz.1_Missense_Mutation_p.P9L|TMEM2_uc010mos.2_Missense_Mutation_p.P953L|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1016						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AGGGTTGGACGGATACTCATC	0.438													20	28					0	0	0	0	A	74319658	A	A	74319658	3	1	241	1	0	0	0	0	1	0	0	0	16187	1116	39	1	1132	1	TMEM2	9	74319658	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	36303557	74319658	66893773	114	44265											
FAM75C1	441452	broad.mit.edu	37	chr9	90538237	90538237	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagagacagacaaatcagaGatcagcagcccttgaaaagt	18	5	9	9	0	2	4	2	1	0	3	2	6	2	4	1	0	2	1	1	0	3	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:90538237G>A	uc010mqi.2	+	4	3444	c.3415G>A	c.(3415-3417)GAT>AAT	p.D1139N	FAM75C1_uc004apq.3_Missense_Mutation_p.D1122N	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						ACAAATCAGAGATCAGCAGCC	0.527													51	190					0	0	0	0	A	90538237	A	A	90538237	3	1	241	1	0	0	0	0	1	0	0	0	5655	942	33	2	3429	2	FAM75C1	9	90538237	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	16218579	90538237	50675194	115	44266											
C9orf102	375748	broad.mit.edu	37	chr9	98678056	98678056	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtaatgtccgcattggcCtcactggaaccatccttcag	10	11	8	12	1	2	0	2	0	0	0	4	1	4	1	4	2	1	2	4	2	3	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:98678056C>T	uc004avt.3	+	5	1316	c.928C>T	c.(928-930)CTC>TTC	p.L310F	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Missense_Mutation_p.L12F|C9orf102_uc010mry.1_Missense_Mutation_p.L12F|C9orf102_uc010mrz.2_Missense_Mutation_p.L121F	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	310	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				CCGCATTGGCCTCACTGGAAC	0.383													12	36					0	0	0	0	T	98678056	T	T	98678056	3	4	241	1	0	0	0	0	1	0	0	0	2457	681	24	4	946	4	C9orf102	9	98678056	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	8139819	98678056	42535375	116	44267											
ACTL7B	10880	broad.mit.edu	37	chr9	111617533	111617533	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggtagttggtgaggtcaccCccagcgtagtcggcgcggct	6	8	16	11	4	1	1	1	1	0	0	2	1	1	1	2	5	1	4	2	5	2	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:111617533C>T	uc004bdi.2	-	1	743	c.678G>A	c.(676-678)GGG>GGA	p.G226G		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	226						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TGAGGTCACCCCCAGCGTAGT	0.647													13	47					0	0	0	0	T	111617533	T	T	111617533	2	4	241	1	0	0	0	0	0	0	0	1	201	610	22	4		4	ACTL7B	9	111617533	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	12939477	111617533	29595898	117	44268											
SVEP1	79987	broad.mit.edu	37	chr9	113169571	113169571	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgcatgaaatggcttcaCagcgtggggaggcaccactc	9	10	12	10	1	1	1	1	1	0	0	2	2	1	2	1	4	2	3	1	4	1	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr9:113169571C>A	uc010mtz.2	-	38	8646	c.8309G>T	c.(8308-8310)TGT>TTT	p.C2770F	SVEP1_uc010mty.2_Missense_Mutation_p.C696F	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2770	Sushi 22.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AATGGCTTCACAGCGTGGGGA	0.468													9	106					2.17888e-05	2.42306e-05	1	0	A	113169571	A	A	113169571	3	1	241	1	0	0	0	0	1	0	0	0	15486	478	17	4	2450	4	SVEP1	9	113169571	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	1552038	113169571	28043860	118	44269											
GATA3	2625	broad.mit.edu	37	chr10	8097767	8097767	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccggaggaggtggatgtgcTttttaacatcgacggtcaag	9	10	15	7	3	1	0	1	0	0	0	2	4	1	3	1	5	2	1	1	5	2	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:8097767T>A	uc001ika.2	+	2	706	c.149T>A	c.(148-150)CTT>CAT	p.L50H	FLJ45983_uc010qbe.1_5'Flank|FLJ45983_uc001ijx.1_5'Flank|FLJ45983_uc010qbf.1_5'Flank|FLJ45983_uc010qbg.1_5'Flank|FLJ45983_uc001ijy.1_5'Flank|GATA3_uc001ijz.2_Missense_Mutation_p.L50H	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	50					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						GTGGATGTGCTTTTTAACATC	0.657			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						6	3					0	0	0	0	A	8097767	A	A	8097767	3	1	241	1	0	0	0	0	1	0	0	0	6290	1609	56	5	151	5	GATA3	10	8097767	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08		8097767	127436980	119	44270											
ERCC6	2074	broad.mit.edu	37	chr10	50678456	50678456	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacactatgatgttttgtttTtgacttgtgcttataaaaat	11	19	6	5	0	0	2	0	2	0	0	0	2	0	2	0	0	1	3	0	0	5	8			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:50678456T>C	uc001jhs.3	-	18	3704	c.3550A>G	c.(3550-3552)AAA>GAA	p.K1184E	ERCC6_uc009xod.2_Missense_Mutation_p.K344E|ERCC6_uc010qgr.1_Missense_Mutation_p.K554E|ERCC6_uc001jhr.3_Missense_Mutation_p.K552E	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1184					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						TGTTTTGTTTTTGACTTGTGC	0.388								Direct_reversal_of_damage|NER					68	100					0	0	0	0	C	50678456	C	C	50678456	3	2	241	1	0	0	0	0	1	0	0	0	5241	1850	64	5	947	5	ERCC6	10	50678456	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	42580689	50678456	84856291	120	44271											
MYST4	23522	broad.mit.edu	37	chr10	76789017	76789017	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcttaatggactgtggcGtcgacctgacagcttcttgt	7	13	12	9	2	2	1	0	1	2	0	3	3	2	2	1	3	1	1	1	3	1	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:76789017G>A	uc001jwn.1	+	18	4928	c.4435G>A	c.(4435-4437)GTC>ATC	p.V1479I	MYST4_uc001jwo.1_Missense_Mutation_p.V1187I|MYST4_uc001jwp.1_Missense_Mutation_p.V1296I	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1479					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					GGACTGTGGCGTCGACCTGAC	0.527			T	CREBBP	AML								16	36					0	0	0	0	A	76789017	A	A	76789017	3	1	241	1	0	0	0	0	1	0	0	0	10158	1145	40	1	4497	1	MYST4	10	76789017	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	26110561	76789017	58745730	121	44272											
PLCE1	51196	broad.mit.edu	37	chr10	95931086	95931086	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaagagcagactatttacCgcagggtcttgccagtcgac	11	8	11	11	2	1	2	0	0	1	2	2	3	1	2	2	1	4	3	2	1	3	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:95931086C>G	uc001kjk.2	+	4	2276	c.1642C>G	c.(1642-1644)CGC>GGC	p.R548G	PLCE1_uc010qnx.1_Missense_Mutation_p.R548G|PLCE1_uc001kjm.2_Missense_Mutation_p.R240G	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	548	Ras-GEF.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GACTATTTACCGCAGGGTCTT	0.547													57	121					0	0	0	0	G	95931086	G	G	95931086	3	3	241	1	0	0	0	0	1	0	0	0	12089	652	23	3	1938	3	PLCE1	10	95931086	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	19142069	95931086	39603661	122	44273											
SEC31B	25956	broad.mit.edu	37	chr10	102247816	102247816	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcttctcatatagatactCcagacgctgggctgcctctt	8	12	9	12	1	2	2	1	0	2	2	4	3	3	2	2	1	3	3	2	1	3	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:102247816C>A	uc001krc.1	-	25	3430	c.3328G>T	c.(3328-3330)GAG>TAG	p.E1110*	SEC31B_uc010qpo.1_Nonsense_Mutation_p.E1109*|SEC31B_uc001krd.1_Nonsense_Mutation_p.E647*|SEC31B_uc001krf.1_Nonsense_Mutation_p.E543*|SEC31B_uc001kre.1_Nonsense_Mutation_p.E541*	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	1110					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		TATAGATACTCCAGACGCTGG	0.527													11	21					6.40141e-05	7.05797e-05	1	0	A	102247816	A	A	102247816	4	1	241	1	0	0	0	0	0	1	0	0	14064	864	30	2	219	2	SEC31B	10	102247816	Nonsense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	6316730	102247816	33286931	123	44274											
ZDHHC6	64429	broad.mit.edu	37	chr10	114194142	114194142	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaccacgtaaatacctgtttAaagttcctccatctacttcc	11	13	4	13	1	1	0	0	0	1	0	4	1	4	0	5	0	2	3	5	0	6	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:114194142A>T	uc001kzv.2	-	7	1240	c.816T>A	c.(814-816)TTT>TTA	p.F272L	ZDHHC6_uc001kzw.2_Missense_Mutation_p.F268L|ZDHHC6_uc009xya.1_Missense_Mutation_p.F272L	NM_022494	NP_071939	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	272						integral to membrane	acyltransferase activity|zinc ion binding				0		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		ATACCTGTTTAAAGTTCCTCC	0.398													5	60					0	0	0	0	T	114194142	T	T	114194142	3	4	241	1	0	0	0	0	1	0	0	0	17686	359	13	5	445	5	ZDHHC6	10	114194142	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	11946326	114194142	21340605	124	44275											
HABP2	3026	broad.mit.edu	37	chr10	115341746	115341746	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gatcaagagaatctatggagGctttaagagcacggcgggca	13	7	14	7	2	2	2	1	0	1	2	2	5	2	3	0	4	1	3	0	4	4	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:115341746G>A	uc001lai.3	+	9	1053	c.950G>A	c.(949-951)GGC>GAC	p.G317D	HABP2_uc010qrz.1_Intron	NM_004132	NP_004123	Q14520	HABP2_HUMAN	hyaluronan binding protein 2 preproprotein	317	Peptidase S1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		ATCTATGGAGGCTTTAAGAGC	0.587													7	97					0	0	0	0	A	115341746	A	A	115341746	3	1	241	1	0	0	0	0	1	0	0	0	6977	1203	42	4	984	4	HABP2	10	115341746	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	1147604	115341746	20193001	125	44276											
EIF3A	8661	broad.mit.edu	37	chr10	120802159	120802159	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	catcatccatgccacgccggGgaacccgatcatcgtctggt	8	8	10	15	4	3	0	2	0	1	0	5	2	4	1	4	3	2	0	4	3	1	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:120802159G>T	uc001ldu.2	-	19	3019	c.2873C>A	c.(2872-2874)CCC>CAC	p.P958H	EIF3A_uc010qsu.1_Missense_Mutation_p.P924H|EIF3A_uc009xzg.1_5'UTR	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	958	4.|Asp-rich.|25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		GCCACGCCGGGGAACCCGATC	0.582													46	118					4.21674e-32	5.46693e-32	1	0	T	120802159	T	T	120802159	3	4	241	1	0	0	0	0	1	0	0	0	5034	1232	43	4	1291	4	EIF3A	10	120802159	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	5460413	120802159	14732588	126	44277											
BAG3	9531	broad.mit.edu	37	chr10	121436667	121436667	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggtgccgtggcagcagacaAgggcaagaaaaatgctggaa	14	4	16	7	1	0	2	0	0	0	2	0	3	0	3	1	4	3	4	1	4	5	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr10:121436667A>G	uc001lem.2	+	4	1907	c.1601A>G	c.(1600-1602)AAG>AGG	p.K534R	BAG3_uc001lel.2_Missense_Mutation_p.K533R	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	534					anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		GCAGCAGACAAGGGCAAGAAA	0.552													23	67					0	0	0	0	G	121436667	G	G	121436667	3	3	241	1	0	0	0	0	1	0	0	0	1290	72	3	5	1615	5	BAG3	10	121436667	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	634508	121436667	14098080	127	44278											
MUC5B	727897	broad.mit.edu	37	chr11	1256320	1256320	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtggccccttgcagcacctGcaggaaccggaggtgggagt	7	7	16	11	1	0	0	0	0	0	0	0	3	0	3	4	5	4	3	4	5	1	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:1256320G>A	uc009ycr.1	+	38	4739	c.4613G>A	c.(4612-4614)TGC>TAC	p.C1538Y	MUC5B_uc009yct.1_Missense_Mutation_p.C879Y|MUC5B_uc001ltb.2_Missense_Mutation_p.C882Y|MUC5B_uc001lta.2_Missense_Mutation_p.C547Y	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	879	VWFC 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TGCAGCACCTGCAGGAACCGG	0.677													10	16					0	0	0	0	A	1256320	A	A	1256320	3	1	241	1	0	0	0	0	1	0	0	0	10032	1319	46	4	2731	4	MUC5B	11	1256320	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08		1256320	133750196	128	44279											
ILK	3611	broad.mit.edu	37	chr11	6631495	6631495	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttgctgacctctccaatatgGagattggaatgaaggtgaga	12	11	12	6	0	1	4	0	3	1	2	2	7	1	5	2	3	1	1	2	3	4	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:6631495G>C	uc001mee.2	+	12	1330	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q	ILK_uc001mef.2_Missense_Mutation_p.E399Q|ILK_uc010rap.1_Missense_Mutation_p.E265Q|ILK_uc010raq.1_Missense_Mutation_p.E338Q|ILK_uc001meg.2_Missense_Mutation_p.E245Q|ILK_uc001meh.2_Missense_Mutation_p.E399Q|ILK_uc001mei.2_Missense_Mutation_p.E25Q	NM_001014794	NP_001014794	Q13418	ILK_HUMAN	integrin-linked kinase	399	Protein kinase.				cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		CTCCAATATGGAGATTGGAAT	0.488													24	30					0	0	0	0	C	6631495	C	C	6631495	3	2	241	1	0	0	0	0	1	0	0	0	7752	1175	41	2	1237	2	ILK	11	6631495	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	5375175	6631495	128375021	129	44280											
MRGPRX2	117194	broad.mit.edu	37	chr11	19077367	19077367	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggacccacagagaaccatgaAtaaaaaaatcagccacgctg	18	4	8	11	1	1	2	1	1	0	1	1	4	1	3	3	1	2	1	3	1	6	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:19077367A>C	uc001mph.2	-	2	671	c.583T>G	c.(583-585)TTC>GTC	p.F195V		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	195	Helical; Name=5; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						AGAACCATGAATAAAAAAATC	0.512													18	13					0	0	0	0	C	19077367	C	C	19077367	3	2	241	1	0	0	0	0	1	0	0	0	9820	101	4	5	413	5	MRGPRX2	11	19077367	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	12445872	19077367	115929149	130	44281											
PEX16	9409	broad.mit.edu	37	chr11	45937775	45937776	+	Splice_Site	INS	-	A	A																															ctgttcttggcagaattctcINSaccacaggcaactttttccg																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:45937775_45937776insA	uc001nbu.2	-	3	537	c.225_splice	c.e3+1	p.V75_splice	PEX16_uc001nbt.2_Splice_Site_p.V75_splice	NM_004813	NP_004804	Q9Y5Y5	PEX16_HUMAN	peroxisomal biogenesis factor 16 isoform 1						ER-dependent peroxisome organization|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein import into peroxisome membrane	endoplasmic reticulum membrane|integral to peroxisomal membrane	protein C-terminus binding			ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.223)		GCAGAATTCTCACCACAGGCAA	0.52													---	---	---								A	45937776	A	A	45937775	8	5	241	1	0	1	1	0	0	0	1	0	11798	841	29	0		0	PEX16	11	45937775	Splice_Site	INS	-	TCGA-CV-7253-01A-11D-2012-08	26860408	45937775	89068741	131	44282											
OR5M9	390162	broad.mit.edu	37	chr11	56230584	56230584	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggcaatgaaaaagtagcaCtgcaccaagcatcccacata	17	5	7	12	1	0	1	0	1	0	0	1	1	1	1	2	1	3	5	2	1	6	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:56230584C>A	uc010rjj.1	-	1	294	c.294G>T	c.(292-294)CAG>CAT	p.Q98H		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	98	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					AAAAGTAGCACTGCACCAAGC	0.488													32	59					9.65021e-13	1.15266e-12	1	0	A	56230584	A	A	56230584	3	1	241	1	0	0	0	0	1	0	0	0	11231	564	20	4	640	4	OR5M9	11	56230584	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	10292809	56230584	78775932	132	44283											
SLC22A9	114571	broad.mit.edu	37	chr11	63137735	63137735	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacactggggccctcagccaAgatgcactcttgagaatctc	10	8	10	13	0	3	2	1	1	2	2	4	4	3	2	2	2	2	1	2	2	2	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:63137735A>T	uc001nww.2	+	1	475	c.207A>T	c.(205-207)CAA>CAT	p.Q69H	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	69	Extracellular (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						CCCTCAGCCAAGATGCACTCT	0.527													26	102					0	0	0	0	T	63137735	T	T	63137735	3	4	241	1	0	0	0	0	1	0	0	0	14525	69	3	5	209	5	SLC22A9	11	63137735	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	6907151	63137735	71868781	133	44284											
ACY3	91703	broad.mit.edu	37	chr11	67412541	67412541	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaagagttcgatgaagtcCagaactgtggccaccagggt	11	9	13	8	1	0	4	0	2	0	2	2	5	1	4	3	2	1	1	3	2	3	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:67412541C>T	uc001omq.2	-	6	780	c.609G>A	c.(607-609)CTG>CTA	p.L203L		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	203					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	CGATGAAGTCCAGAACTGTGG	0.617													58	116					0	0	0	0	T	67412541	T	T	67412541	2	4	241	1	0	0	0	0	0	0	0	1	227	581	21	4		4	ACY3	11	67412541	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	4274806	67412541	67593975	134	44285											
OR8G2	26492	broad.mit.edu	37	chr11	124096301	124096301	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccatgctgaacccccaaTctatagcctaagaaataagg	14	8	7	12	0	1	2	0	1	1	1	1	2	1	2	4	1	4	1	4	1	7	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr11:124096301T>A	uc010saf.1	+	1	904	c.904T>A	c.(904-906)TCT>ACT	p.S302T		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	302						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GAACCCCCAATCTATAGCCTA	0.418													6	112					0	0	0	0	A	124096301	A	A	124096301	3	1	241	1	0	0	0	0	1	0	0	0	11289	1435	50	5	906	5	OR8G2	11	124096301	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	56683760	124096301	10910215	135	44286											
CACNA1C	775	broad.mit.edu	37	chr12	2760859	2760859	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttccgcctgttccgggtCatgcgtctggtgaagctgct	3	14	12	12	3	3	1	1	1	2	0	5	1	5	1	3	2	3	3	3	2	1	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:2760859C>A	uc009zdu.1	+	34	4456	c.4143C>A	c.(4141-4143)GTC>GTA	p.V1381V	CACNA1C_uc009zdv.1_Silent_p.V1330V|CACNA1C_uc001qkb.2_Silent_p.V1333V|CACNA1C_uc001qkc.2_Silent_p.V1333V|CACNA1C_uc001qke.2_Silent_p.V1322V|CACNA1C_uc001qkf.2_Silent_p.V1322V|CACNA1C_uc001qjz.2_Silent_p.V1333V|CACNA1C_uc001qkd.2_Silent_p.V1333V|CACNA1C_uc001qkg.2_Silent_p.V1320V|CACNA1C_uc009zdw.1_Silent_p.V1355V|CACNA1C_uc001qkh.2_Silent_p.V1322V|CACNA1C_uc001qkl.2_Silent_p.V1381V|CACNA1C_uc001qkn.2_Silent_p.V1333V|CACNA1C_uc001qko.2_Silent_p.V1353V|CACNA1C_uc001qkp.2_Silent_p.V1333V|CACNA1C_uc001qkr.2_Silent_p.V1350V|CACNA1C_uc001qku.2_Silent_p.V1333V|CACNA1C_uc001qkq.2_Silent_p.V1361V|CACNA1C_uc001qks.2_Silent_p.V1333V|CACNA1C_uc001qkt.2_Silent_p.V1333V|CACNA1C_uc001qki.1_Silent_p.V1069V|CACNA1C_uc001qkj.1_Silent_p.V1069V|CACNA1C_uc001qkk.1_Silent_p.V1069V|CACNA1C_uc001qkm.1_Silent_p.V1058V|CACNA1C_uc010sea.1_Silent_p.V24V	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1381	Helical; Name=S4 of repeat IV; (Potential).|IV.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGTTCCGGGTCATGCGTCTGG	0.617													33	57					3.90053e-15	4.76936e-15	1	0	A	2760859	A	A	2760859	2	1	241	1	0	0	0	0	0	0	0	1	2552	813	29	2		2	CACNA1C	12	2760859	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08		2760859	131091036	136	44287											
PRMT8	56341	broad.mit.edu	37	chr12	3686072	3686072	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggctttgacatgacctgcAtccgggacgtggccatgaag	9	9	13	10	2	0	3	0	3	0	0	1	4	1	4	3	3	1	2	3	3	1	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:3686072A>G	uc001qmf.2	+	7	1115	c.748A>G	c.(748-750)ATC>GTC	p.I250V	PRMT8_uc009zed.2_Missense_Mutation_p.I241V|PRMT8_uc009zee.1_RNA|PRMT8_uc001qmg.2_Missense_Mutation_p.I64V	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	250					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	p.I250M(1)		ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CATGACCTGCATCCGGGACGT	0.572													16	264					0	0	0	0	G	3686072	G	G	3686072	3	3	241	1	0	0	0	0	1	0	0	0	12604	217	8	5	774	5	PRMT8	12	3686072	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	925213	3686072	130165823	137	44288											
A2ML1	144568	broad.mit.edu	37	chr12	9020506	9020506	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacatgccatctgaggagatCaacctggttgtaaaatccac	13	10	8	10	0	2	2	1	1	1	1	3	3	3	2	3	2	3	2	3	2	4	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:9020506C>G	uc001quz.3	+	30	3884	c.3786C>G	c.(3784-3786)ATC>ATG	p.I1262M	A2ML1_uc001qva.1_Missense_Mutation_p.I842M|A2ML1_uc010sgm.1_Missense_Mutation_p.I762M|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1106						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						CTGAGGAGATCAACCTGGTTG	0.453													33	44					0	0	0	0	G	9020506	G	G	9020506	3	3	241	1	0	0	0	0	1	0	0	0	5	816	29	2	3904	2	A2ML1	12	9020506	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	5334434	9020506	124831389	138	44289											
GSG1	83445	broad.mit.edu	37	chr12	13238169	13238169	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagcaggtgaaggagagcCaggccatgctagggacaaat	13	5	15	8	0	0	2	0	1	0	1	0	4	0	3	2	4	4	3	2	4	3	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:13238169C>A	uc001rbn.2	-	7	928	c.755G>T	c.(754-756)TGG>TTG	p.W252L	GSG1_uc001rbj.2_Missense_Mutation_p.W216L|GSG1_uc001rbk.2_Silent_p.L257L|GSG1_uc001rbl.2_Missense_Mutation_p.W188L|GSG1_uc001rbm.2_Missense_Mutation_p.W165L|GSG1_uc001rbo.2_Silent_p.L293L|GSG1_uc001rbp.2_Missense_Mutation_p.W229L|GSG1_uc001rbq.1_Silent_p.L293L	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	239	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GAAGGAGAGCCAGGCCATGCT	0.483													13	35					2.27111e-07	2.58126e-07	1	0	A	13238169	A	A	13238169	3	1	241	1	0	0	0	0	1	0	0	0	6859	595	21	4	337	4	GSG1	12	13238169	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	4217663	13238169	120613726	139	44290											
LASS5	91012	broad.mit.edu	37	chr12	50535844	50535844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttaagactcaccgaccagaGaaatctaattccatagcaga	16	8	7	10	1	2	3	1	0	1	3	3	5	3	3	3	0	1	2	3	0	4	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:50535844G>A	uc001rwd.3	-	4	501	c.484C>T	c.(484-486)CTC>TTC	p.L162F	LASS5_uc001rwc.2_Missense_Mutation_p.L81F|LASS5_uc001rwe.3_Missense_Mutation_p.L103F|LASS5_uc001rwf.3_Intron|LASS5_uc010smq.1_Missense_Mutation_p.L18F	NM_147190	NP_671723	Q8N5B7	CERS5_HUMAN	LAG1 homolog, ceramide synthase 5	162	TLC.|Helical; (Potential).				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0						ACCGACCAGAGAAATCTAATT	0.363													11	15					0	0	0	0	A	50535844	A	A	50535844	3	1	241	1	0	0	0	0	1	0	0	0	8682	942	33	2	722	2	LASS5	12	50535844	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	37297675	50535844	83316051	140	44291											
POU6F1	5463	broad.mit.edu	37	chr12	51590624	51590624	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgactgctgatccctggCatgctgggaatggcgctggt	6	11	14	10	1	1	2	0	2	1	0	2	3	2	3	1	4	2	4	1	4	1	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:51590624C>T	uc001rxy.2	-	1	195	c.3G>A	c.(1-3)ATG>ATA	p.M1I	POU6F1_uc001rxz.2_Missense_Mutation_p.M1I|POU6F1_uc001rya.2_Missense_Mutation_p.M1I	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	1	Gln/Pro-rich.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGATCCCTGGCATGCTGGGAA	0.612													6	84					0	0	0	0	T	51590624	T	T	51590624	3	4	241	1	0	0	0	0	1	0	0	0	12339	710	25	4	922	4	POU6F1	12	51590624	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	1054780	51590624	82261271	141	44292											
MAP3K12	7786	broad.mit.edu	37	chr12	53878059	53878059	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctgggacttaaagtaagtCtcctggggtgtggagagtac	10	10	14	7	0	1	1	0	0	1	1	2	3	1	2	2	4	1	2	2	4	4	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:53878059C>T	uc001sdm.1	-	8	1229	c.1131G>A	c.(1129-1131)GAG>GAA	p.E377E	MAP3K12_uc001sdn.1_Silent_p.E410E	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	377					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						TAAAGTAAGTCTCCTGGGGTG	0.488													11	31					0	0	0	0	T	53878059	T	T	53878059	2	4	241	1	0	0	0	0	0	0	0	1	9299	912	32	2		2	MAP3K12	12	53878059	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	2287435	53878059	79973836	142	44293											
EEA1	8411	broad.mit.edu	37	chr12	93196253	93196253	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagagtttttcaaagaatcaGaaacttttgatagtttgtcc	13	16	7	5	0	2	4	2	1	0	3	3	4	3	4	1	0	1	2	1	0	5	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:93196253G>C	uc001tck.2	-	19	2862	c.2597C>G	c.(2596-2598)TCT>TGT	p.S866C		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	866	Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						CAAAGAATCAGAAACTTTTGA	0.308													8	16					0	0	0	0	C	93196253	C	C	93196253	3	2	241	1	0	0	0	0	1	0	0	0	4943	942	33	2	1682	2	EEA1	12	93196253	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	39318194	93196253	40655642	143	44294											
GNPTAB	79158	broad.mit.edu	37	chr12	102155370	102155370	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagttcttgcataacaatccGgtcaatcatgtgaggcatgt	11	12	9	9	1	3	1	2	1	1	0	4	1	4	1	1	2	2	3	1	2	3	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:102155370G>C	uc001tit.2	-	14	3066	c.2887C>G	c.(2887-2889)CGG>GGG	p.R963G		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	963					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						ATAACAATCCGGTCAATCATG	0.388													24	38					0	0	0	0	C	102155370	C	C	102155370	3	2	241	1	0	0	0	0	1	0	0	0	6582	1115	39	3	915	3	GNPTAB	12	102155370	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	8959117	102155370	31696525	144	44295											
SLC41A2	84102	broad.mit.edu	37	chr12	105282861	105282861	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccacactgctagagcacagaAgtatggaatgatcaaggtaa	16	7	10	8	0	1	3	1	1	0	2	1	4	1	4	1	2	2	4	1	2	6	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:105282861A>T	uc001tla.2	-	4	997	c.830T>A	c.(829-831)CTT>CAT	p.L277H		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	277	Cytoplasmic.					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						AGAGCACAGAAGTATGGAATG	0.398													18	43					0	0	0	0	T	105282861	T	T	105282861	3	4	241	1	0	0	0	0	1	0	0	0	14694	72	3	5	919	5	SLC41A2	12	105282861	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	3127491	105282861	28569034	145	44296											
RNF10	9921	broad.mit.edu	37	chr12	121013686	121013686	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcccagttttcaaaattcCttcagccaagctattgaagc	11	12	7	11	0	2	1	2	1	0	0	3	1	3	1	3	0	4	2	3	0	5	6			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:121013686C>T	uc001typ.3	+	16	2775	c.2292C>T	c.(2290-2292)TCC>TCT	p.S764S	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Silent_p.S675S	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	764					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCAAAATTCCTTCAGCCAAG	0.478													93	136					0	0	0	0	T	121013686	T	T	121013686	2	4	241	1	0	0	0	0	0	0	0	1	13487	668	24	4		4	RNF10	12	121013686	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	15730825	121013686	12838209	146	44297											
TMEM120B	144404	broad.mit.edu	37	chr12	122181639	122181639	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagcacctcaaggacttgaaGcttacactccagaggtaggt	13	8	10	10	0	1	2	1	1	0	1	2	3	2	3	2	3	3	3	2	3	5	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:122181639G>A	uc001ubc.3	+	2	318	c.174G>A	c.(172-174)AAG>AAA	p.K58K	TMEM120B_uc009zxh.2_Silent_p.K58K	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	58	Potential.					integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		AGGACTTGAAGCTTACACTCC	0.418													32	43					0	0	0	0	A	122181639	A	A	122181639	2	1	241	1	0	0	0	0	0	0	0	1	16100	962	34	4		4	TMEM120B	12	122181639	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	1167953	122181639	11670256	147	44298											
SBNO1	55206	broad.mit.edu	37	chr12	123782584	123782584	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctgcatcttcacgtttgtgCcactgacagatgctagaaca	10	12	8	11	1	3	3	1	1	2	2	3	3	3	3	1	0	4	3	1	0	2	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:123782584C>T	uc010tap.1	-	30	3980	c.3980G>A	c.(3979-3981)GGC>GAC	p.G1327D	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.G1326D|SBNO1_uc010taq.1_Missense_Mutation_p.G278D	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1327							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CACGTTTGTGCCACTGACAGA	0.428													5	108					0	0	0	0	T	123782584	T	T	123782584	3	4	241	1	0	0	0	0	1	0	0	0	13927	739	26	4	209	4	SBNO1	12	123782584	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	1600945	123782584	10069311	148	44299											
DNAH10	196385	broad.mit.edu	37	chr12	124377980	124377980	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggacctggtgcagaaacttcCcaggtacccgcggtggagcc	8	6	14	13	2	0	1	0	0	0	1	1	3	1	3	4	5	4	2	4	5	2	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr12:124377980C>T	uc001uft.3	+	52	8867	c.8842C>T	c.(8842-8844)CCA>TCA	p.P2948S		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2948	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAGAAACTTCCCAGGTACCCG	0.572													30	55					0	0	0	0	T	124377980	T	T	124377980	3	4	241	1	0	0	0	0	1	0	0	0	4620	623	22	4	9048	4	DNAH10	12	124377980	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	595396	124377980	9473915	149	44300											
USP12	219333	broad.mit.edu	37	chr13	27649390	27649390	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggattggtggcatcaccTgaagtgttaaacagacgaag	12	10	12	7	1	2	2	1	1	1	1	2	4	2	3	1	3	1	2	1	3	4	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:27649390T>C	uc001uqy.2	-	7	1123	c.870A>G	c.(868-870)TCA>TCG	p.S290S		NM_182488	NP_872294	O75317	UBP12_HUMAN	ubiquitin thiolesterase 12	290					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		TGGCATCACCTGAAGTGTTAA	0.408													17	48					0	0	0	0	C	27649390	C	C	27649390	2	2	241	1	0	0	0	0	0	0	0	1	17111	1567	55	5		5	USP12	13	27649390	Silent	SNP	T	TCGA-CV-7253-01A-11D-2012-08		27649390	87520488	150	44301											
FRY	10129	broad.mit.edu	37	chr13	32798467	32798468	+	Frame_Shift_Ins	INS	-	C	C																															ttgtactggaggatgctgggINScccccctggttgactatctc																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:32798467_32798468insC	uc001utx.2	+	37	5357_5358	c.4861_4862insC	c.(4861-4863)GCCfs	p.A1621fs	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1621					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AGGATGCTGGGCCCCCCTGGTT	0.569													---	---	---								C	32798468	C	C	32798467	7	5	241	1	0	1	1	0	0	0	0	0	6097	1203	42	0	5007	0	FRY	13	32798467	Frame_Shift_Ins	INS	-	TCGA-CV-7253-01A-11D-2012-08	5149077	32798467	82371411	151	44302											
POSTN	10631	broad.mit.edu	37	chr13	38160349	38160349	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctcaaaagcctcattggtGggagcaaagagtgtgaagtg	12	10	13	6	0	2	2	2	1	1	1	3	3	2	3	1	2	2	1	1	2	4	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:38160349G>T	uc001uwo.3	-	7	940	c.822C>A	c.(820-822)CCC>CCA	p.P274P	POSTN_uc001uwp.3_Silent_p.P274P|POSTN_uc001uwr.2_Silent_p.P274P|POSTN_uc001uwq.2_Silent_p.P274P|POSTN_uc010teu.1_Silent_p.P274P|POSTN_uc010tev.1_Silent_p.P274P|POSTN_uc010tew.1_Silent_p.P274P|POSTN_uc010tex.1_Silent_p.P189P	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	274	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CCTCATTGGTGGGAGCAAAGA	0.468													19	54					8.28177e-16	1.02234e-15	1	0	T	38160349	T	T	38160349	2	4	241	1	0	0	0	0	0	0	0	1	12314	1335	47	4		4	POSTN	13	38160349	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	5361882	38160349	77009529	152	44303											
C13orf23	80209	broad.mit.edu	37	chr13	39588614	39588614	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttgctggggtggaaaatgCtatatggaagggggaaaaaa	15	8	15	3	0	0	0	0	0	0	0	0	3	0	3	0	6	2	2	0	6	8	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:39588614C>G	uc001uwy.2	-	11	1649	c.776_splice	c.e11-1	p.T259_splice	C13orf23_uc001uwz.2_Splice_Site_p.T237_splice	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1											ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		GTGGAAAATGCTATATGGAAG	0.388													8	23					0	0	0	0	G	39588614	G	G	39588614	5	3	241	1	0	0	0	0	0	0	1	0	1727	811	28	4	2071	4	C13orf23	13	39588614	Splice_Site	SNP	C	TCGA-CV-7253-01A-11D-2012-08	1428265	39588614	75581264	153	44304											
NAA16	79612	broad.mit.edu	37	chr13	41891057	41891057	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcgaacccaaaatttgctGaacatggaggtattgtctca	12	12	9	8	1	1	1	1	1	1	0	3	3	1	2	1	2	3	2	1	2	5	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:41891057G>T	uc001uyf.2	+	2	454	c.130G>T	c.(130-132)GAA>TAA	p.E44*	NAA16_uc010tfg.1_RNA|NAA16_uc001uye.3_Nonsense_Mutation_p.E44*|NAA16_uc001uyd.3_Nonsense_Mutation_p.E44*	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	44					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						AAAATTTGCTGAACATGGAGG	0.368													8	18					7.48243e-07	8.46696e-07	1	0	T	41891057	T	T	41891057	4	4	241	1	0	0	0	0	0	1	0	0	10172	1291	45	2	136	2	NAA16	13	41891057	Nonsense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	2302443	41891057	73278821	154	44305											
RASA3	22821	broad.mit.edu	37	chr13	114839224	114839225	+	Frame_Shift_Ins	INS	-	A	A																															tttccacaattttggtcctgINSaaaacctcctcctggtccag																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:114839224_114839225insA	uc001vui.2	-	2	274_275	c.143_144insT	c.(142-144)TTCfs	p.F48fs	RASA3_uc010tkk.1_Frame_Shift_Ins_p.F16fs|RASA3_uc001vuj.2_5'UTR|RASA3_uc010tkl.1_RNA	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	48	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			TTTTGGTCCTGAAAACCTCCTC	0.465													---	---	---								A	114839225	A	A	114839224	7	5	241	1	0	1	1	0	0	0	0	0	13127	1281	45	0	2452	0	RASA3	13	114839224	Frame_Shift_Ins	INS	-	TCGA-CV-7253-01A-11D-2012-08	72948167	114839224	330654	155	44306											
CDC16	8881	broad.mit.edu	37	chr13	115002175	115002175	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agtagcttcactctctcgtgGtaagtgacaaaatgctaact	12	12	8	9	1	2	1	1	1	1	0	4	1	2	1	0	1	3	4	0	1	5	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr13:115002175G>T	uc001vuk.1	+	2	301	c.103_splice	c.e2+1	p.E35_splice	CDC16_uc010tkm.1_Splice_Site_p.E35_splice|CDC16_uc001vul.1_Splice_Site_p.E35_splice|CDC16_uc001vum.1_Splice_Site|CDC16_uc001vun.1_Splice_Site_p.E35_splice|CDC16_uc001vuo.1_Splice_Site_p.E35_splice	NM_003903	NP_003894	Q13042	CDC16_HUMAN	anaphase-promoting complex, subunit 6						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding				0	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			CTCTCTCGTGGTAAGTGACAA	0.358													21	50					3.8784e-16	4.83395e-16	1	0	T	115002175	T	T	115002175	5	4	241	1	0	0	0	0	0	0	1	0	3073	1275	44	4	110	4	CDC16	13	115002175	Splice_Site	SNP	G	TCGA-CV-7253-01A-11D-2012-08	162951	115002175	167703	156	44307											
PABPN1	8106	broad.mit.edu	37	chr14	23777304	23777304	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgcactgtgtgctgagAgtgtcaacaaggagatggaa	11	8	16	6	0	1	2	1	1	0	2	1	5	1	3	0	3	3	3	0	3	3	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr14:23777304A>C	uc001wjh.3	+	3	516	c.328A>C	c.(328-330)AGT>CGT	p.S110R	BCL2L2_uc001wjg.3_Missense_Mutation_p.S110R|BCL2L2_uc001wji.3_Missense_Mutation_p.S110R	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	Error:Variant_position_missing_in_Q86U42_after_alignment					modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GTGTGCTGAGAGTGTCAACAA	0.582													39	50					0	0	0	0	C	23777304	C	C	23777304	3	2	241	1	0	0	0	0	1	0	0	0	11422	304	11	5		5	PABPN1	14	23777304	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08		23777304	83572236	157	44308											
NYNRIN	57523	broad.mit.edu	37	chr14	24880367	24880367	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggacaccgagaggtcactGtgtttgtacccacctggcag	8	8	14	11	1	1	1	1	0	0	1	1	3	1	2	3	4	1	3	3	4	1	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr14:24880367G>T	uc001wpf.3	+	5	2818	c.2500G>T	c.(2500-2502)GTG>TTG	p.V834L		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	834					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						AGAGGTCACTGTGTTTGTACC	0.592											OREG0022626	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	65					3.77171e-38	4.9396e-38	1	0	T	24880367	T	T	24880367	3	4	241	1	0	0	0	0	1	0	0	0	10850	1377	48	4	2514	4	NYNRIN	14	24880367	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	1103063	24880367	82469173	158	44309											
AKAP6	9472	broad.mit.edu	37	chr14	33015409	33015409	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctaaacgggggactggttCaggcaaacaagctaaaaata	17	6	10	8	1	1	0	1	0	0	0	1	1	1	1	1	4	3	3	1	4	8	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr14:33015409C>T	uc001wrq.2	+	4	1720	c.1550C>T	c.(1549-1551)TCA>TTA	p.S517L	AKAP6_uc010aml.2_Missense_Mutation_p.S514L	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	517					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GGGACTGGTTCAGGCAAACAA	0.463													29	49					0	0	0	0	T	33015409	T	T	33015409	3	4	241	1	0	0	0	0	1	0	0	0	455	838	29	2	1560	2	AKAP6	14	33015409	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	8135042	33015409	74334131	159	44310											
FSCB	84075	broad.mit.edu	37	chr14	44975866	44975866	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tacatcctgaacactctctgGcaattcaatagcagcttctc	11	12	5	13	0	3	1	1	1	2	0	6	1	4	1	1	1	4	3	1	1	5	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr14:44975866G>T	uc001wvn.2	-	1	634	c.325C>A	c.(325-327)CCA>ACA	p.P109T		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	109						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		ACACTCTCTGGCAATTCAATA	0.418													45	97					2.35958e-20	2.99888e-20	1	0	T	44975866	T	T	44975866	3	4	241	1	0	0	0	0	1	0	0	0	6100	1203	42	4	2156	4	FSCB	14	44975866	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	11960457	44975866	62373674	160	44311											
C14orf159	80017	broad.mit.edu	37	chr14	91642340	91642340	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgccatggtgtgtcccccaGgggaggttccagtgttctgg	5	11	15	10	0	1	0	0	0	1	0	3	1	3	1	4	5	1	2	4	5	0	2	rs75931548	byFrequency	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr14:91642340G>T	uc001xzb.2	+	9	1423	c.655G>T	c.(655-657)GGG>TGG	p.G219W	C14orf159_uc010atv.1_RNA|C14orf159_uc001xyy.2_Missense_Mutation_p.G224W|C14orf159_uc001xyx.2_Missense_Mutation_p.G207W|C14orf159_uc001xyw.2_Missense_Mutation_p.G224W|C14orf159_uc001xzc.2_Missense_Mutation_p.G219W|C14orf159_uc001xza.2_Missense_Mutation_p.G224W|C14orf159_uc001xyv.2_Missense_Mutation_p.G224W|C14orf159_uc001xyz.2_Missense_Mutation_p.G95W|C14orf159_uc001xze.2_Missense_Mutation_p.G219W	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	219						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		GTGTCCCCCAGGGGAGGTTCC	0.537													26	45					4.43304e-23	5.69016e-23	1	0	T	91642340	T	T	91642340	3	4	241	1	0	0	0	0	1	0	0	0	1761	1000	35	4	688	4	C14orf159	14	91642340	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	46666474	91642340	15707200	161	44312											
OR4N4	283694	broad.mit.edu	37	chr15	22383155	22383155	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctgccatgttcgtagggCagcttctgaagggaagaaca	10	9	12	10	1	2	2	0	1	2	1	3	3	2	3	2	2	3	4	2	2	4	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:22383155C>A	uc001yuc.1	+	7	1664	c.683C>A	c.(682-684)GCA>GAA	p.A228E	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Missense_Mutation_p.A228E	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GTTCGTAGGGCAGCTTCTGAA	0.493													37	324					9.80977e-26	1.26546e-25	1	0	A	22383155	A	A	22383155	3	1	241	1	0	0	0	0	1	0	0	0	11132	710	25	4	685	4	OR4N4	15	22383155	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08		22383155	80148237	162	44313											
SPG11	80208	broad.mit.edu	37	chr15	44941138	44941138	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtgtccacagtgctggcacTtccatggatcatgagtctgt	8	12	11	10	0	2	1	1	1	1	0	4	2	4	2	2	2	1	2	2	2	0	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:44941138T>A	uc001ztx.2	-	7	1559	c.1528A>T	c.(1528-1530)AGT>TGT	p.S510C	SPG11_uc010ueh.1_Missense_Mutation_p.S510C|SPG11_uc010uei.1_Missense_Mutation_p.S510C|SPG11_uc001zua.1_Missense_Mutation_p.S510C	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	510	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		GTGCTGGCACTTCCATGGATC	0.398													14	42					0	0	0	0	A	44941138	A	A	44941138	3	1	241	1	0	0	0	0	1	0	0	0	15107	1609	56	5	5939	5	SPG11	15	44941138	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	22557983	44941138	57590254	163	44314											
SPG11	80208	broad.mit.edu	37	chr15	44941194	44941195	+	Frame_Shift_Del	DEL	AG	-	-																															gagtcaaaccaaacaaaatcAgagagagtccattctctata																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:44941194_44941195delAG	uc001ztx.2	-	7	1502_1503	c.1471_1472delCT	c.(1471-1473)CTGfs	p.L491fs	SPG11_uc010ueh.1_Frame_Shift_Del_p.L491fs|SPG11_uc010uei.1_Frame_Shift_Del_p.L491fs|SPG11_uc001zua.1_Frame_Shift_Del_p.L491fs	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	491	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AAACAAAATCAGAGAGAGTCCA	0.337													---	---	---								-	44941195	-	-	44941194	7	5	241	1	0	1	0	1	0	0	0	0	15107	188	7	0	5995	0	SPG11	15	44941194	Frame_Shift_Del	DEL	AG	TCGA-CV-7253-01A-11D-2012-08	56	44941194	57590198	164	44315											
LINGO1	84894	broad.mit.edu	37	chr15	77907870	77907870	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcttcaggcggttgctgcGgagacccagcgtccggaggt	6	7	17	11	4	1	1	1	0	0	1	2	4	2	2	2	5	4	3	2	5	0	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:77907870G>A	uc002bct.1	-	2	431	c.379C>T	c.(379-381)CGC>TGC	p.R127C	LINGO1_uc002bcu.1_Missense_Mutation_p.R121C	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	127	Extracellular (Potential).|LRR 3.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						CGGTTGCTGCGGAGACCCAGC	0.602													13	25					0	0	0	0	A	77907870	A	A	77907870	3	1	241	1	0	0	0	0	1	0	0	0	8856	1116	39	1	1487	1	LINGO1	15	77907870	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	32966676	77907870	24623522	165	44316											
CHRNA3	1136	broad.mit.edu	37	chr15	78894291	78894291	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggatgtacagcgagtatgtGatgtcggggtagatctcctc	8	11	14	8	3	1	2	0	1	1	1	4	4	1	3	1	3	2	3	1	3	3	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:78894291G>T	uc002bec.2	-	5	879	c.693C>A	c.(691-693)ATC>ATA	p.I231I	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Silent_p.I231I	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	231	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						GCGAGTATGTGATGTCGGGGT	0.547													22	29					9.95505e-16	1.22305e-15	1	0	T	78894291	T	T	78894291	2	4	241	1	0	0	0	0	0	0	0	1	3399	1280	45	2		2	CHRNA3	15	78894291	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	986421	78894291	23637101	166	44317											
KIAA1199	57214	broad.mit.edu	37	chr15	81225737	81225737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatgacaactggctggtccGgcacccagactgcatcaatg	11	7	11	12	1	1	2	1	1	0	1	2	3	2	2	2	3	2	3	2	3	3	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr15:81225737G>A	uc002bfw.1	+	22	3205	c.2945G>A	c.(2944-2946)CGG>CAG	p.R982Q	KIAA1199_uc010unn.1_Missense_Mutation_p.R982Q	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	982										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TGGCTGGTCCGGCACCCAGAC	0.582													29	70					0	0	0	0	A	81225737	A	A	81225737	3	1	241	1	0	0	0	0	1	0	0	0	8252	1116	39	1	3027	1	KIAA1199	15	81225737	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	2331446	81225737	21305655	167	44318											
PDPK1	5170	broad.mit.edu	37	chr16	2611896	2611899	+	Frame_Shift_Del	DEL	CGAC	-	-																															ctttacttcacatttcaggaCgacgagaagctgtgtatcct																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:2611896_2611899delCGAC	uc002cqs.2	+	4	597_600	c.453_456delCGAC	c.(451-456)GACGACfs	p.D151fs	PDPK1_uc002cqt.2_Intron|PDPK1_uc010bsn.2_Frame_Shift_Del_p.D151fs|PDPK1_uc002cqu.2_Frame_Shift_Del_p.D124fs|PDPK1_uc002cqv.1_Frame_Shift_Del_p.D124fs|PDPK1_uc010uwe.1_3'UTR|uc010bsp.1_3'UTR	NM_002613	NP_002604	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	151_152	Protein kinase.				actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|ovary(1)	3		Ovarian(90;0.17)			Celecoxib(DB00482)	CATTTCAGGACGACGAGAAGCTGT	0.52													---	---	---								-	2611899	-	-	2611896	7	5	241	1	0	1	0	1	0	0	0	0	11741	535	19	0	467	0	PDPK1	16	2611896	Frame_Shift_Del	DEL	CGAC	TCGA-CV-7253-01A-11D-2012-08		2611896	87742857	168	44319											
TRAP1	10131	broad.mit.edu	37	chr16	3722789	3722789	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagtgcaacgctggagccCagctcccggctcacatcaaa	11	6	9	15	2	2	0	2	0	0	0	3	1	3	1	2	2	5	4	2	2	3	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:3722789C>T	uc002cvt.3	-	10	1166	c.1077G>A	c.(1075-1077)CTG>CTA	p.L359L	TRAP1_uc002cvs.2_Silent_p.L150L|TRAP1_uc010uxf.1_Silent_p.L306L	NM_016292	NP_057376	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1 precursor	359					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(1)	1		Ovarian(90;0.0261)				CGCTGGAGCCCAGCTCCCGGC	0.622													5	12					0	0	0	0	T	3722789	T	T	3722789	2	4	241	1	0	0	0	0	0	0	0	1	16522	581	21	4		4	TRAP1	16	3722789	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	1110893	3722789	86631964	169	44320											
TGFB1I1	7041	broad.mit.edu	37	chr16	31485728	31485728	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccacctcagccactctggaGctggatagactgatggcctc	8	8	11	14	0	2	2	1	1	1	1	3	4	2	4	4	3	2	1	4	3	1	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:31485728G>T	uc002ecd.1	+	6	497	c.471G>T	c.(469-471)GAG>GAT	p.E157D	TGFB1I1_uc002ece.1_Missense_Mutation_p.E140D|TGFB1I1_uc010caq.1_5'UTR	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	157	Transcription activation (By similarity).|LD motif 3.|Interaction with PTK2B.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						CCACTCTGGAGCTGGATAGAC	0.572													14	81					2.32078e-09	2.73408e-09	1	0	T	31485728	T	T	31485728	3	4	241	1	0	0	0	0	1	0	0	0	15883	962	34	4	493	4	TGFB1I1	16	31485728	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	27762939	31485728	58869025	170	44321											
CNGB1	1258	broad.mit.edu	37	chr16	57994742	57994742	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctctcccttccttggctcAcctcagaggatttggggggc	4	11	12	14	0	3	1	2	0	1	1	5	2	4	2	4	5	0	1	4	5	0	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:57994742A>G	uc002emt.2	-	8	599	c.534_splice	c.e8+1	p.E178_splice	CNGB1_uc010cdh.2_Splice_Site_p.E178_splice|CNGB1_uc002emu.2_Splice_Site_p.E178_splice	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform						sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						TCCTTGGCTCACCTCAGAGGA	0.642													14	30					0	0	0	0	G	57994742	G	G	57994742	5	3	241	1	0	0	0	0	0	0	1	0	3615	173	6	5	3353	5	CNGB1	16	57994742	Splice_Site	SNP	A	TCGA-CV-7253-01A-11D-2012-08	26509014	57994742	32360011	171	44322											
CNOT1	23019	broad.mit.edu	37	chr16	58572083	58572083	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcgctaggtgaagatcataCtgctgcatattaaccaaatg	13	11	9	8	1	1	2	1	1	0	1	1	2	1	2	1	1	5	3	1	1	6	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:58572083C>T	uc002env.2	-	37	5516	c.5223G>A	c.(5221-5223)CAG>CAA	p.Q1741Q	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.Q1736Q|CNOT1_uc010vik.1_Silent_p.Q698Q	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1741					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GAAGATCATACTGCTGCATAT	0.403													7	23					0	0	0	0	T	58572083	T	T	58572083	2	4	241	1	0	0	0	0	0	0	0	1	3632	564	20	4		4	CNOT1	16	58572083	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	577341	58572083	31782670	172	44323											
CDH11	1009	broad.mit.edu	37	chr16	65038544	65038544	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attgagggaaggcagccttaCcctgcccacaagcacggggt	10	6	13	12	1	0	1	0	1	0	0	0	2	0	2	3	4	4	2	3	4	3	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:65038544C>A	uc002eoi.2	-	3	662	c.228_splice	c.e3+1	p.R76_splice	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Splice_Site_p.R76_splice|CDH11_uc010vin.1_Intron|CDH11_uc010vio.1_Splice_Site_p.R76_splice	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GGCAGCCTTACCCTGCCCACA	0.572			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			17	16					9.7654e-05	0.000106757	1	0	A	65038544	A	A	65038544	5	1	241	1	0	0	0	0	0	0	1	0	3112	521	18	4	2205	4	CDH11	16	65038544	Splice_Site	SNP	C	TCGA-CV-7253-01A-11D-2012-08	6466461	65038544	25316209	173	44324											
CTCF	10664	broad.mit.edu	37	chr16	67650762	67650762	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccattcaagtgttccatgtGcgattacgccagtgtagaag	10	11	11	9	2	1	1	1	0	0	1	2	2	2	1	3	0	2	2	3	0	4	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:67650762G>T	uc002etl.2	+	5	1357	c.1067G>T	c.(1066-1068)TGC>TTC	p.C356F	CTCF_uc010cek.2_Missense_Mutation_p.C28F	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	356	C2H2-type 4.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		TGTTCCATGTGCGATTACGCC	0.448													80	130					1.06985e-64	1.42279e-64	1	0	T	67650762	T	T	67650762	3	4	241	1	0	0	0	0	1	0	0	0	4017	1319	46	4	1077	4	CTCF	16	67650762	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	2612218	67650762	22703991	174	44325											
ESRP2	80004	broad.mit.edu	37	chr16	68265188	68265188	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccacctccacgtagcgcTccttcatcaccttcttatgg	7	11	7	16	2	3	0	2	0	1	0	5	1	5	1	5	2	1	2	5	2	2	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr16:68265188T>A	uc010cfa.1	-	12	1822	c.1634A>T	c.(1633-1635)GAG>GTG	p.E545V	ESRP2_uc002evp.1_Intron|ESRP2_uc002evq.1_Missense_Mutation_p.E535V	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	545	RRM 3.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1						CACGTAGCGCTCCTTCATCAC	0.617													21	39					0	0	0	0	A	68265188	A	A	68265188	3	1	241	1	0	0	0	0	1	0	0	0	5283	1551	54	5	565	5	ESRP2	16	68265188	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	614426	68265188	22089565	175	44326											
OVCA2	124641	broad.mit.edu	37	chr17	1945365	1945365	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gccgcgcagcgacccctgcgGgtcctgtgcctggcgggctt	2	7	16	16	5	0	0	0	0	0	0	1	1	1	0	5	3	3	2	5	3	0	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:1945365G>A	uc002ftx.2	+	1	89	c.24G>A	c.(22-24)CGG>CGA	p.R8R	DPH1_uc002ftr.1_Intron|DPH1_uc002fts.2_Intron|DPH1_uc002ftt.2_Intron|DPH1_uc010cjx.2_Intron|DPH1_uc010vqs.1_Intron|DPH1_uc002ftu.2_Intron|DPH1_uc002ftv.2_Intron|DPH1_uc002ftw.2_3'UTR	NM_080822	NP_543012	Q8WZ82	OVCA2_HUMAN	candidate tumor suppressor in ovarian cancer 2	8					response to retinoic acid	cytoplasm	hydrolase activity				0						GACCCCTGCGGGTCCTGTGCC	0.716											OREG0024078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	4					0	0	0	0	A	1945365	A	A	1945365	2	1	241	1	0	0	0	0	0	0	0	1	11376	1219	43	4		4	OVCA2	17	1945365	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08		1945365	79249845	176	44327											
TRPV3	162514	broad.mit.edu	37	chr17	3419860	3419860	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactccaagatggtcctggCtctctggggacataagcaag	12	8	11	10	0	1	1	0	0	1	1	4	2	3	2	2	4	2	2	2	4	4	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:3419860C>T	uc002fvt.1	-	16	2411	c.2089G>A	c.(2089-2091)GCC>ACC	p.A697T	SPATA22_uc010vrg.1_5'Flank|TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Missense_Mutation_p.A681T|TRPV3_uc010vri.1_Missense_Mutation_p.A652T|TRPV3_uc010vrj.1_Missense_Mutation_p.A681T|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Missense_Mutation_p.A681T|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Missense_Mutation_p.A697T|TRPV3_uc002fvu.2_Missense_Mutation_p.A697T	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	697	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	ATGGTCCTGGCTCTCTGGGGA	0.537													13	12					0	0	0	0	T	3419860	T	T	3419860	3	4	241	1	0	0	0	0	1	0	0	0	16664	797	28	4	295	4	TRPV3	17	3419860	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	1474495	3419860	77775350	177	44328											
ZZEF1	23140	broad.mit.edu	37	chr17	3977538	3977538	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccccaagacacggcaacAtcgggcagcccacaggcagt	12	2	11	16	2	0	1	0	0	0	1	1	1	0	1	3	3	3	3	3	3	2	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:3977538A>G	uc002fxe.2	-	24	3655	c.3591T>C	c.(3589-3591)GAT>GAC	p.D1197D		NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1197							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACACGGCAACATCGGGCAGCC	0.587											OREG0024096	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	84	70					0	0	0	0	G	3977538	G	G	3977538	2	3	241	1	0	0	0	0	0	0	0	1	18322	214	8	5		5	ZZEF1	17	3977538	Silent	SNP	A	TCGA-CV-7253-01A-11D-2012-08	557678	3977538	77217672	178	44329											
ZNF232	7775	broad.mit.edu	37	chr17	5009729	5009729	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttttctgagaacacctgtGattccacttcagtaatgggt	9	15	9	8	0	2	2	1	2	1	1	3	3	3	2	2	1	1	2	2	1	2	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:5009729G>T	uc002gas.2	-	5	1398	c.644C>A	c.(643-645)TCA>TAA	p.S215*	ZNF232_uc002gar.1_Nonsense_Mutation_p.S233*|ZNF232_uc002gat.2_Nonsense_Mutation_p.S242*	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	215					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						GAACACCTGTGATTCCACTTC	0.448													30	14					1.39806e-14	1.68551e-14	1	0	T	5009729	T	T	5009729	4	4	241	1	0	0	0	0	0	1	0	0	17852	1294	45	2	613	2	ZNF232	17	5009729	Nonsense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	1032191	5009729	76185481	179	44330											
TP53	7157	broad.mit.edu	37	chr17	7577126	7577126	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaggcacaaacacgcaccTcaaagctgttccgtcccagt	12	6	8	15	2	1	0	1	0	0	0	3	1	3	0	3	1	2	4	3	1	2	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:7577126T>A	uc002gim.2	-	8	1006	c.812A>T	c.(811-813)GAG>GTG	p.E271V	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E271V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E139V|TP53_uc010cng.1_Missense_Mutation_p.E139V|TP53_uc002gii.1_Missense_Mutation_p.E139V|TP53_uc010cnh.1_Missense_Mutation_p.E271V|TP53_uc010cni.1_Missense_Mutation_p.E271V|TP53_uc002gij.2_Missense_Mutation_p.E271V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	271	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> A (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(22)|p.E271*(14)|p.0?(7)|p.E271V(5)|p.E271Q(3)|p.E271G(3)|p.E271D(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.E271E(2)|p.E271fs*73(1)|p.E258fs*71(1)|p.E271_R273delEVR(1)|p.F270fs*72(1)|p.S269fs*21(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.E271P(1)|p.E271del(1)|p.S269fs*34(1)|p.E271fs*34(1)|p.E271fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACACGCACCTCAAAGCTGTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	9					0	0	0	0	A	7577126	A	A	7577126	3	1	241	1	0	0	0	0	1	0	0	0	16448	1551	54	5	474	5	TP53	17	7577126	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	2567397	7577126	73618084	180	44331											
DNAH9	1770	broad.mit.edu	37	chr17	11554533	11554533	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggcaaattggtacaacaagGttatgaaaactctgctggag	14	10	11	6	0	1	1	0	1	1	0	1	2	1	2	0	4	4	4	0	4	7	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:11554533G>T	uc002gne.2	+	13	2313	c.2245G>T	c.(2245-2247)GTT>TTT	p.V749F	DNAH9_uc010coo.2_Missense_Mutation_p.V43F	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	749	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTACAACAAGGTTATGAAAAC	0.463													5	69					0.00116845	0.0012457	1	0	T	11554533	T	T	11554533	3	4	241	1	0	0	0	0	1	0	0	0	4630	1261	44	4	2295	4	DNAH9	17	11554533	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	3977407	11554533	69640677	181	44332											
MYO15A	51168	broad.mit.edu	37	chr17	18075505	18075505	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacctatgttcggctcctcCttcttcttcatccagagctg	5	16	6	14	1	3	1	1	0	2	1	7	1	6	1	4	1	2	3	4	1	2	6			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:18075505C>T	uc010vxh.1	+	63	10589	c.10251C>T	c.(10249-10251)TCC>TCT	p.S3417S	MYO15A_uc010vxi.1_Silent_p.S681S|MYO15A_uc010vxk.1_Silent_p.S110S|MYO15A_uc010vxl.1_Silent_p.S406S|MYO15A_uc002gsl.2_Intron|MYO15A_uc010vxm.1_Missense_Mutation_p.P241L|MYO15A_uc010cpv.2_RNA	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3417	Tail.|FERM.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TCGGCTCCTCCTTCTTCTTCA	0.582													4	33					0	0	0	0	T	18075505	T	T	18075505	2	4	241	1	0	0	0	0	0	0	0	1	10116	668	24	4		4	MYO15A	17	18075505	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	6520972	18075505	63119705	182	44333											
MYO18A	399687	broad.mit.edu	37	chr17	27426719	27426719	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggaacagggttaggttcCtgctggtttgttcatcccgc	5	14	12	10	1	1	0	1	0	0	0	3	1	3	1	2	4	2	5	2	4	2	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:27426719C>T	uc002hdt.1	-	22	3727	c.3569G>A	c.(3568-3570)AGG>AAG	p.R1190K	MYO18A_uc010wbc.1_Missense_Mutation_p.R732K|MYO18A_uc002hds.2_Missense_Mutation_p.R732K|MYO18A_uc010csa.1_Missense_Mutation_p.R1190K|MYO18A_uc002hdu.1_Missense_Mutation_p.R1190K|MYO18A_uc010wbd.1_Missense_Mutation_p.R859K	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1190	IQ.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GGTTAGGTTCCTGCTGGTTTG	0.607													12	29					0	0	0	0	T	27426719	T	T	27426719	3	4	241	1	0	0	0	0	1	0	0	0	10118	681	24	4	2679	4	MYO18A	17	27426719	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	9351214	27426719	53768491	183	44334											
TAOK1	57551	broad.mit.edu	37	chr17	27857580	27857580	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaggaacagacccggaaattAgctatcttggctgagcagta	13	8	12	8	1	1	2	0	1	1	1	1	5	1	4	1	3	3	4	1	3	5	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:27857580A>T	uc002hdz.1	+	18	2498	c.2304A>T	c.(2302-2304)TTA>TTT	p.L768F	TAOK1_uc010wbe.1_Missense_Mutation_p.L620F|TAOK1_uc010wbf.1_Missense_Mutation_p.L768F	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	768	Potential.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			CCCGGAAATTAGCTATCTTGG	0.443													28	37					0	0	0	0	T	27857580	T	T	27857580	3	4	241	1	0	0	0	0	1	0	0	0	15613	417	15	5	2370	5	TAOK1	17	27857580	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	430861	27857580	53337630	184	44335											
ACCN1	40	broad.mit.edu	37	chr17	32483076	32483076	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcaggtcatggcccacaCggtgcaggaactccagcatg	9	7	11	14	1	2	0	2	0	0	0	3	1	3	1	3	4	3	2	3	4	1	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:32483076C>T	uc002hhu.2	-	1	750	c.476G>A	c.(475-477)CGT>CAT	p.R159H		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	159	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	ATGGCCCACACGGTGCAGGAA	0.562													39	74					0	0	0	0	T	32483076	T	T	32483076	3	4	241	1	0	0	0	0	1	0	0	0	128	536	19	1	1814	1	ACCN1	17	32483076	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	4625496	32483076	48712134	185	44336											
G6PC	2538	broad.mit.edu	37	chr17	41056042	41056043	+	Frame_Shift_Del	DEL	TG	-	-																															taaagcagttccctgtaaccTgtgagactggaccaggtaag																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:41056042_41056043delTG	uc002icb.1	+	2	404_405	c.325_326delTG	c.(325-327)TGTfs	p.C109fs	G6PC_uc010whf.1_Frame_Shift_Del_p.C111fs	NM_000151	NP_000142	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	109	Lumenal (Potential).				gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CCCTGTAACCTGTGAGACTGGA	0.515									Glycogen_Storage_Disease_type_Ia				---	---	---								-	41056043	-	-	41056042	7	5	241	1	0	1	0	1	0	0	0	0	6177	1580	55	0	331	0	G6PC	17	41056042	Frame_Shift_Del	DEL	TG	TCGA-CV-7253-01A-11D-2012-08	8572966	41056042	40139168	186	44337											
MAPT	4137	broad.mit.edu	37	chr17	44096055	44096055	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagtcgaagattgggtccCtggacaatatcacccacgtc	10	9	9	13	2	1	1	1	0	0	1	5	3	3	2	3	2	0	0	3	2	3	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:44096055C>A	uc002ijr.3	+	13	2340	c.2020C>A	c.(2020-2022)CTG>ATG	p.L674M	MAPT_uc010dau.2_Missense_Mutation_p.L692M|MAPT_uc002ijs.3_Missense_Mutation_p.L357M|MAPT_uc002ijx.3_Missense_Mutation_p.L328M|MAPT_uc002ijt.3_Missense_Mutation_p.L299M|MAPT_uc002iju.3_Missense_Mutation_p.L268M|MAPT_uc002ijv.3_Missense_Mutation_p.L275M	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	674	Tau/MAP 4.				cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				GATTGGGTCCCTGGACAATAT	0.493													6	186					3.59834e-05	3.98442e-05	1	0	A	44096055	A	A	44096055	3	1	241	1	0	0	0	0	1	0	0	0	9350	680	24	4	2124	4	MAPT	17	44096055	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	3040013	44096055	37099155	187	44338											
ACSF2	80221	broad.mit.edu	37	chr17	48548429	48548429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacagtcccgtgacattcgCgcacttccctgaggacactg	9	8	10	14	3	0	2	0	2	0	0	3	4	2	3	2	1	1	1	2	1	1	2	rs148600715		TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:48548429C>T	uc002iqu.2	+	11	1360	c.1256C>T	c.(1255-1257)GCG>GTG	p.A419V	ACSF2_uc010wml.1_Missense_Mutation_p.A376V|ACSF2_uc010wmm.1_Missense_Mutation_p.A444V|ACSF2_uc010wmn.1_Missense_Mutation_p.A406V|ACSF2_uc010wmo.1_Missense_Mutation_p.A259V|CHAD_uc010dbr.2_5'Flank|CHAD_uc010dbs.2_5'Flank|ACSF2_uc010dbt.1_5'UTR	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2 precursor	419					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GTGACATTCGCGCACTTCCCT	0.562													33	54					0	0	0	0	T	48548429	T	T	48548429	3	4	241	1	0	0	0	0	1	0	0	0	175	768	27	1	1298	1	ACSF2	17	48548429	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	4452374	48548429	32646781	188	44339											
CACNA1G	8913	broad.mit.edu	37	chr17	48694921	48694921	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgcatcatgagggtgctgcGcattgcccgaggttggtgcc	5	9	15	12	3	1	1	1	1	0	0	1	2	1	1	3	3	4	4	3	3	0	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:48694921G>C	uc002irk.1	+	29	5516	c.5144G>C	c.(5143-5145)CGC>CCC	p.R1715P	CACNA1G_uc002irj.1_Missense_Mutation_p.R1681P|CACNA1G_uc002irl.1_Missense_Mutation_p.R1692P|CACNA1G_uc002irm.1_Missense_Mutation_p.R1681P|CACNA1G_uc002irn.1_Missense_Mutation_p.R1674P|CACNA1G_uc002iro.1_Missense_Mutation_p.R1681P|CACNA1G_uc002irp.1_Missense_Mutation_p.R1715P|CACNA1G_uc002irq.1_Missense_Mutation_p.R1692P|CACNA1G_uc002irr.1_Missense_Mutation_p.R1715P|CACNA1G_uc002irs.1_Missense_Mutation_p.R1704P|CACNA1G_uc002irt.1_Missense_Mutation_p.R1697P|CACNA1G_uc002irv.1_Missense_Mutation_p.R1704P|CACNA1G_uc002irw.1_Missense_Mutation_p.R1692P|CACNA1G_uc002iru.1_Missense_Mutation_p.R1681P|CACNA1G_uc002irx.1_Missense_Mutation_p.R1628P|CACNA1G_uc002iry.1_Missense_Mutation_p.R1617P|CACNA1G_uc002irz.1_Missense_Mutation_p.R1628P|CACNA1G_uc002isa.1_Missense_Mutation_p.R1594P|CACNA1G_uc002isb.1_Missense_Mutation_p.R1635P|CACNA1G_uc002isc.1_Missense_Mutation_p.R1617P|CACNA1G_uc002isd.1_Missense_Mutation_p.R1610P|CACNA1G_uc002ise.1_Missense_Mutation_p.R1583P|CACNA1G_uc002isf.1_Missense_Mutation_p.R1610P|CACNA1G_uc002isg.1_Missense_Mutation_p.R1576P|CACNA1G_uc002ish.1_Missense_Mutation_p.R1583P|CACNA1G_uc002isi.1_Missense_Mutation_p.R1571P	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1715	IV.|Helical; Name=S4 of repeat IV; (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AGGGTGCTGCGCATTGCCCGA	0.622													12	81					0	0	0	0	C	48694921	C	C	48694921	3	2	241	1	0	0	0	0	1	0	0	0	2556	1087	38	3	5525	3	CACNA1G	17	48694921	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	146492	48694921	32500289	189	44340											
MPO	4353	broad.mit.edu	37	chr17	56355336	56355336	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggttggacatgttgcgcagGttcctggccaggggctcctc	4	11	15	11	1	0	0	0	0	0	0	3	1	2	1	3	6	1	5	3	6	0	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:56355336G>T	uc002ivu.1	-	7	1233	c.1056C>A	c.(1054-1056)AAC>AAA	p.N352K		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	352					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	TGTTGCGCAGGTTCCTGGCCA	0.642													26	78					1.42536e-11	1.68689e-11	1	0	T	56355336	T	T	56355336	3	4	241	1	0	0	0	0	1	0	0	0	9785	1252	44	4	1205	4	MPO	17	56355336	Missense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	7660415	56355336	24839874	190	44341											
KIAA0195	9772	broad.mit.edu	37	chr17	73485427	73485427	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcagtcggtgatgctacActatgctgtgcccgtggtcc	6	11	13	11	2	0	1	0	1	0	0	2	1	1	1	2	2	5	3	2	2	2	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:73485427A>G	uc002jnz.3	+	8	1120	c.845A>G	c.(844-846)CAC>CGC	p.H282R	KIAA0195_uc010wsa.1_Missense_Mutation_p.H292R|KIAA0195_uc010wsb.1_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	282	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTGATGCTACACTATGCTGTG	0.637													10	68					0	0	0	0	G	73485427	G	G	73485427	3	3	241	1	0	0	0	0	1	0	0	0	8199	159	6	5	871	5	KIAA0195	17	73485427	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	17130091	73485427	7709783	191	44342											
C17orf101	79701	broad.mit.edu	37	chr17	80350347	80350348	+	Missense_Mutation	DNP	CC	AA	AA																															tggtgatggcgtaacgggtgCcccagtggaccttctccacg																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr17:80350347_80350348CC>AA	uc002keu.1	-	9	987_988	c.886_887GG>TT	c.(886-888)GGC>TTC	p.G296F	C17orf101_uc002ket.1_3'UTR|C17orf101_uc010dip.1_RNA	NM_024648	NP_078924	Q6PK18	CQ101_HUMAN	hypothetical protein LOC79701 isoform 1	296	Fe2OG dioxygenase.|Lumenal (Potential).					integral to membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)	1						GTAACGGGTGCCCCAGTGGACC	0.624													5	21					0	0	0	0	AA	80350348	AA	AA	80350347	3	1	241	1	0	0	0	0	1	0	0	0	1854	739	26	4	76	4	C17orf101	17	80350347	Missense_Mutation	DNP	CC	TCGA-CV-7253-01A-11D-2012-08	6864920	80350347	844863	192	44343											
CEP192	55125	broad.mit.edu	37	chr18	13057679	13057679	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgcttaatccaactgacCgctggctgcaagtcagcatt	9	11	10	11	1	1	1	1	1	0	0	2	1	2	1	2	1	4	5	2	1	3	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr18:13057679C>T	uc010xac.1	+	20	4284	c.4204C>T	c.(4204-4206)CGC>TGC	p.R1402C	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.R927C|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Missense_Mutation_p.R1143C	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1402										ovary(4)|pancreas(1)	5						TCCAACTGACCGCTGGCTGCA	0.502													48	13					0	0	0	0	T	13057679	T	T	13057679	3	4	241	1	0	0	0	0	1	0	0	0	3266	652	23	1	4278	1	CEP192	18	13057679	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08		13057679	65019569	193	44344											
PIAS2	9063	broad.mit.edu	37	chr18	44424058	44424058	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggctagttgtagcaatttCactatcaggatctgcagtaa	13	12	9	7	0	3	0	2	0	1	0	3	1	3	1	0	2	2	6	0	2	6	6			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr18:44424058C>A	uc002lck.2	-	8	1158	c.1000G>T	c.(1000-1002)GAA>TAA	p.E334*	PIAS2_uc010dnp.2_Nonsense_Mutation_p.E32*|PIAS2_uc002lcl.2_Nonsense_Mutation_p.E334*|PIAS2_uc010xda.1_Nonsense_Mutation_p.E32*|PIAS2_uc002lcm.2_Nonsense_Mutation_p.E334*|PIAS2_uc002lcn.1_Nonsense_Mutation_p.E338*	NM_004671	NP_004662	O75928	PIAS2_HUMAN	protein inhibitor of activated STAT X isoform	334	SP-RING-type.				androgen receptor signaling pathway|negative regulation of androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|PML body	androgen receptor binding|DNA binding|protein binding|SUMO ligase activity|transcription coactivator activity|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						GTAGCAATTTCACTATCAGGA	0.294													24	23					5.61819e-17	7.03637e-17	1	0	A	44424058	A	A	44424058	4	1	241	1	0	0	0	0	0	1	0	0	11931	835	29	2	968	2	PIAS2	18	44424058	Nonsense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	31366379	44424058	33653190	194	44345											
MUC16	94025	broad.mit.edu	37	chr19	9082378	9082378	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggcaggaactgaaatagagCttgcccatgtttctggagaa	12	10	12	7	0	1	3	0	1	1	2	1	5	1	4	1	3	3	3	1	3	4	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:9082378C>G	uc002mkp.2	-	1	9641	c.9437G>C	c.(9436-9438)AGC>ACC	p.S3146T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3147	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGAAATAGAGCTTGCCCATGT	0.473													22	24					0	0	0	0	G	9082378	G	G	9082378	3	3	241	1	0	0	0	0	1	0	0	0	10026	797	28	4	34422	4	MUC16	19	9082378	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08		9082378	50046605	195	44346											
SMARCA4	6597	broad.mit.edu	37	chr19	11096928	11096928	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttccagccagtggcccgtCttcggggccccagatgtctt	5	10	12	14	2	2	1	0	0	2	1	4	1	3	1	5	3	1	1	5	3	0	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:11096928C>A	uc002mqf.3	+	4	703	c.419C>A	c.(418-420)TCT>TAT	p.S140Y	SMARCA4_uc010dxp.2_Missense_Mutation_p.S140Y|SMARCA4_uc010dxo.2_Missense_Mutation_p.S140Y|SMARCA4_uc002mqg.1_Missense_Mutation_p.S140Y|SMARCA4_uc010dxq.2_Missense_Mutation_p.S140Y|SMARCA4_uc010dxr.2_Missense_Mutation_p.S140Y|SMARCA4_uc002mqj.3_Missense_Mutation_p.S140Y|SMARCA4_uc010dxs.2_Missense_Mutation_p.S140Y|SMARCA4_uc002mqe.2_Missense_Mutation_p.S140Y	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	140	Necessary for interaction with SS18L1/CREST (By similarity).				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AGTGGCCCGTCTTCGGGGCCC	0.662			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				28	21					6.38683e-12	7.59356e-12	1	0	A	11096928	A	A	11096928	3	1	241	1	0	0	0	0	1	0	0	0	14834	913	32	2	429	2	SMARCA4	19	11096928	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	2014550	11096928	48032055	196	44347											
CYP4F11	57834	broad.mit.edu	37	chr19	16034706	16034706	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcatcaataccctgagtgggGagggtgcagcgccgctcctg	7	8	14	12	2	2	1	2	1	0	0	3	2	3	2	3	3	3	2	3	3	2	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:16034706G>A	uc002nbu.2	-	7	870	c.834C>T	c.(832-834)CTC>CTT	p.L278L	CYP4F11_uc010eab.1_Silent_p.L278L|CYP4F11_uc002nbt.2_Silent_p.L278L	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	278					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						CCTGAGTGGGGAGGGTGCAGC	0.542													69	90					0	0	0	0	A	16034706	A	A	16034706	2	1	241	1	0	0	0	0	0	0	0	1	4203	1161	41	2		2	CYP4F11	19	16034706	Silent	SNP	G	TCGA-CV-7253-01A-11D-2012-08	4937778	16034706	43094277	197	44348											
FAM129C	199786	broad.mit.edu	37	chr19	17654420	17654420	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taccttttgtgctgagccaaCtcgagccaggctgcaaaaag	11	9	10	11	1	0	1	0	1	0	0	1	2	0	1	3	1	6	3	3	1	4	3	rs10401716	byFrequency	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:17654420C>A	uc010xpr.1	+	13	1765	c.1627C>A	c.(1627-1629)CTC>ATC	p.L543I	FAM129C_uc010xpq.1_Missense_Mutation_p.L543I|FAM129C_uc002ngy.3_Missense_Mutation_p.L269I|FAM129C_uc010xpu.1_Missense_Mutation_p.L269I|FAM129C_uc002ngz.3_RNA|FAM129C_uc010eaw.2_Intron|FAM129C_uc002nhb.2_Missense_Mutation_p.L172I	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	543											0						GCTGAGCCAACTCGAGCCAGG	0.502													3	23					0.004672	0.0049604	1	0	A	17654420	A	A	17654420	3	1	241	1	0	0	0	0	1	0	0	0	5466	565	20	4	1677	4	FAM129C	19	17654420	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	1619714	17654420	41474563	198	44349											
B3GNT3	10331	broad.mit.edu	37	chr19	17918965	17918965	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctggtgatcaagtcctccCctagcaactatgtgcgccgc	7	10	10	14	2	1	1	1	1	0	0	3	1	3	1	4	1	4	2	4	1	4	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:17918965C>T	uc002nhk.1	+	2	434	c.349C>T	c.(349-351)CCT>TCT	p.P117S	B3GNT3_uc002nhl.1_Missense_Mutation_p.P117S|B3GNT3_uc010ebd.1_Missense_Mutation_p.P117S|B3GNT3_uc010ebe.1_Missense_Mutation_p.P117S	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	117	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						CAAGTCCTCCCCTAGCAACTA	0.667													9	32					0	0	0	0	T	17918965	T	T	17918965	3	4	241	1	0	0	0	0	1	0	0	0	1260	623	22	4	351	4	B3GNT3	19	17918965	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	264545	17918965	41210018	199	44350											
SFRS14	10147	broad.mit.edu	37	chr19	19130026	19130026	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccactaccctgtgatctgctCgctgggggacagctggaaca	8	8	12	13	1	1	1	0	1	1	0	2	3	1	3	2	3	4	3	2	3	2	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:19130026C>T	uc002nkx.2	-	4	1888	c.1742G>A	c.(1741-1743)CGA>CAA	p.R581Q	SFRS14_uc002nkz.1_Missense_Mutation_p.R595Q|SFRS14_uc002nla.1_Missense_Mutation_p.R581Q|SFRS14_uc002nlb.2_Missense_Mutation_p.R581Q|SFRS14_uc010xqk.1_Missense_Mutation_p.R350Q	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	581					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			GTGATCTGCTCGCTGGGGGAC	0.522													15	27					0	0	0	0	T	19130026	T	T	19130026	3	4	241	1	0	0	0	0	1	0	0	0	14235	884	31	1	1534	1	SFRS14	19	19130026	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	1211061	19130026	39998957	200	44351											
ZNF676	163223	broad.mit.edu	37	chr19	22363996	22363996	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccagttaaaagctttgcCattttcttcacatttgtagg	10	15	8	8	0	2	0	1	0	1	0	2	1	2	1	2	2	2	3	2	2	3	7			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:22363996C>A	uc002nqs.1	-	3	841	c.523G>T	c.(523-525)GGC>TGC	p.G175C		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	175	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAAGCTTTGCCATTTTCTTCA	0.338													25	33					8.24728e-16	1.02234e-15	1	0	A	22363996	A	A	22363996	3	1	241	1	0	0	0	0	1	0	0	0	18150	594	21	4	1247	4	ZNF676	19	22363996	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	3233970	22363996	36764987	201	44352											
ZNF536	9745	broad.mit.edu	37	chr19	30936598	30936598	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctctcccagaccgggagtgCccaggaggacagcccgcacc	8	3	12	18	2	1	1	0	0	1	1	2	4	1	4	6	3	2	1	6	3	0	0			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:30936598C>A	uc002nsu.1	+	2	2267	c.2129C>A	c.(2128-2130)GCC>GAC	p.A710D	ZNF536_uc010edd.1_Missense_Mutation_p.A710D	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	710					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					ACCGGGAGTGCCCAGGAGGAC	0.682													4	60					0.00909568	0.00950075	1	0	A	30936598	A	A	30936598	3	1	241	1	0	0	0	0	1	0	0	0	18041	739	26	4	2131	4	ZNF536	19	30936598	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	8572602	30936598	28192385	202	44353											
ZFP14	57677	broad.mit.edu	37	chr19	36853054	36853054	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tagttctcccacattacatcCctatataagtccctctgagc	10	13	4	14	0	2	1	0	1	2	0	5	1	4	1	3	0	2	1	3	0	5	6			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:36853054C>T	uc002odx.1	-	2	189	c.96G>A	c.(94-96)AGG>AGA	p.R32R	ZFP14_uc010xtd.1_Silent_p.R32R|ZFP14_uc010eex.1_Silent_p.R32R	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					ACATTACATCCCTATATAAGT	0.403													8	48					0	0	0	0	T	36853054	T	T	36853054	2	4	241	1	0	0	0	0	0	0	0	1	17706	622	22	4		4	ZFP14	19	36853054	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	5916456	36853054	22275929	203	44354											
ZFP36	7538	broad.mit.edu	37	chr19	39899199	39899199	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tacagtccctgggatccgacCctgatgaatatgccagcagc	10	8	10	13	1	0	2	0	2	0	0	2	4	2	3	4	1	4	1	4	1	3	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:39899199C>A	uc002olh.1	+	2	899	c.841C>A	c.(841-843)CCT>ACT	p.P281T	ZFP36_uc010egn.1_Silent_p.T153T	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	281					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGGATCCGACCCTGATGAATA	0.667													26	82					7.41945e-09	8.66162e-09	1	0	A	39899199	A	A	39899199	3	1	241	1	0	0	0	0	1	0	0	0	17712	623	22	4	847	4	ZFP36	19	39899199	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	3046145	39899199	19229784	204	44355											
HIPK4	147746	broad.mit.edu	37	chr19	40886277	40886277	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttgggcccatcctcatctcGctgcaggatggccagtggct	5	10	13	13	1	2	0	1	0	1	0	4	1	3	1	3	4	1	4	3	4	0	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:40886277G>A	uc002onp.2	-	3	1906	c.1621C>T	c.(1621-1623)CGA>TGA	p.R541*		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	541						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TCCTCATCTCGCTGCAGGATG	0.622													38	76					0	0	0	0	A	40886277	A	A	40886277	4	1	241	1	0	0	0	0	0	1	0	0	7158	1095	38	1	237	1	HIPK4	19	40886277	Nonsense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08	987078	40886277	18242706	205	44356											
RCN3	57333	broad.mit.edu	37	chr19	50046458	50046458	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggacctgacccggcaccaCgatgagctgtgagcaccgcg	9	4	14	14	4	0	3	0	3	0	0	0	6	0	4	4	2	2	3	4	2	0	0	rs149927163		TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:50046458C>T	uc002poj.2	+	7	1422	c.975C>T	c.(973-975)CAC>CAT	p.H325H		NM_020650	NP_065701	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	325	Prevents secretion from ER (Potential).					endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		CCCGGCACCACGATGAGCTGT	0.647													10	27					0	0	0	0	T	50046458	T	T	50046458	2	4	241	1	0	0	0	0	0	0	0	1	13246	535	19	1		1	RCN3	19	50046458	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	9160181	50046458	9082525	206	44357											
PRR12	57479	broad.mit.edu	37	chr19	50105149	50105149	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgggacgagttcgtcatcCgtgctgaggacatcccttcc	8	9	11	13	4	1	1	1	1	0	0	5	4	4	3	3	2	2	2	3	2	1	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:50105149C>T	uc002poo.3	+	6	4747	c.4747C>T	c.(4747-4749)CGT>TGT	p.R1583C		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	762							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GTTCGTCATCCGTGCTGAGGA	0.547													4	32					0	0	0	0	T	50105149	T	T	50105149	3	4	241	1	0	0	0	0	1	0	0	0	12646	652	23	1	4769	1	PRR12	19	50105149	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	58691	50105149	9023834	207	44358											
CD33	945	broad.mit.edu	37	chr19	51728815	51728815	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggagagaggaagtaccaaaTacagttacaaatctccccag	16	7	9	9	0	1	1	0	0	1	1	2	4	1	3	3	2	3	2	3	2	6	3	rs146181856	byFrequency	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:51728815T>C	uc002pwa.2	+	2	419	c.379T>C	c.(379-381)TAC>CAC	p.Y127H	CD33_uc010eos.1_Missense_Mutation_p.Y127H|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	127	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	AAGTACCAAATACAGTTACAA	0.532													53	44					0	0	0	0	C	51728815	C	C	51728815	3	2	241	1	0	0	0	0	1	0	0	0	3020	1406	49	5	385	5	CD33	19	51728815	Missense_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08	1623666	51728815	7400168	208	44359											
NLRP5	126206	broad.mit.edu	37	chr19	56539846	56539846	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttcccaagagatgagtcCgctgaggcatgtcctgtggt	8	11	12	10	1	1	3	0	2	1	1	4	4	4	3	3	2	0	2	3	2	1	1	rs149649207	by1000genomes	TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr19:56539846C>T	uc002qmj.2	+	7	2247	c.2247C>T	c.(2245-2247)TCC>TCT	p.S749S	NLRP5_uc002qmi.2_Silent_p.S730S	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	749	LRR 2.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GAGATGAGTCCGCTGAGGCAT	0.517													19	290					0	0	0	0	T	56539846	T	T	56539846	2	4	241	1	0	0	0	0	0	0	0	1	10534	639	23	1		1	NLRP5	19	56539846	Silent	SNP	C	TCGA-CV-7253-01A-11D-2012-08	4811031	56539846	2589137	209	44360											
PLCB4	5332	broad.mit.edu	37	chr20	9391725	9391725	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggaaaatttgagtataatGgatcgtgcgggtgagtaata	14	11	14	2	2	0	2	0	2	0	0	1	4	0	4	0	3	1	2	0	3	6	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr20:9391725G>T	uc002wnf.2	+	23	2141	c.2005G>T	c.(2005-2007)GGA>TGA	p.G669*	PLCB4_uc010gbw.1_Nonsense_Mutation_p.G669*|PLCB4_uc010gbx.2_Nonsense_Mutation_p.G681*|PLCB4_uc002wne.2_Nonsense_Mutation_p.G669*|PLCB4_uc002wnh.2_Nonsense_Mutation_p.G516*	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	669	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TGAGTATAATGGATCGTGCGG	0.368													12	35					7.03913e-09	8.25498e-09	1	0	T	9391725	T	T	9391725	4	4	241	1	0	0	0	0	0	1	0	0	12085	1349	47	4	2127	4	PLCB4	20	9391725	Nonsense_Mutation	SNP	G	TCGA-CV-7253-01A-11D-2012-08		9391725	53633795	210	44361											
PAX1	5075	broad.mit.edu	37	chr20	21695398	21695398	+	Frame_Shift_Del	DEL	T	-	-																															gccggacccaccacacttccTttattggtctgggtttttag																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr20:21695398delT	uc002wsj.2	+	5	1616	c.1562delT	c.(1561-1563)CTTfs	p.L521fs	PAX1_uc010zsl.1_3'UTR|PAX1_uc010zsm.1_3'UTR	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	521					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						CCACACTTCCTTTATTGGTCT	0.637													---	---	---								-	21695398	-	-	21695398	7	5	241	1	0	1	0	1	0	0	0	0	11532	1609	56	0	1580	0	PAX1	20	21695398	Frame_Shift_Del	DEL	T	TCGA-CV-7253-01A-11D-2012-08	12303673	21695398	41330122	211	44362											
KIF3B	9371	broad.mit.edu	37	chr20	30904034	30904034	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cactcaggccatggagagtaAgttgcttgttggaggaaaaa	13	9	13	6	0	1	1	1	0	0	1	1	4	1	3	1	4	1	4	1	4	3	4			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr20:30904034A>C	uc002wxq.2	+	3	1585	c.1418A>C	c.(1417-1419)AAG>ACG	p.K473T	KIF3B_uc010ztw.1_Missense_Mutation_p.K411T	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	473	Potential.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ATGGAGAGTAAGTTGCTTGTT	0.408													11	79					0	0	0	0	C	30904034	C	C	30904034	3	2	241	1	0	0	0	0	1	0	0	0	8340	72	3	5	1424	5	KIF3B	20	30904034	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	9208636	30904034	32121486	212	44363											
ZBP1	81030	broad.mit.edu	37	chr20	56189965	56189965	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggcggtaaatcgtccatgcTttggactgctcatccatgtc	7	12	11	11	2	1	0	1	0	0	0	5	1	3	1	2	3	2	3	2	3	2	2			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr20:56189965T>C	uc002xyo.2	-	4	761	c.480A>G	c.(478-480)AAA>AAG	p.K160K	ZBP1_uc010gjm.2_Silent_p.K160K|ZBP1_uc002xyp.2_Silent_p.K85K|ZBP1_uc010zzn.1_Silent_p.K160K	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	160	DRADA 2.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			TCGTCCATGCTTTGGACTGCT	0.557													57	121					0	0	0	0	C	56189965	C	C	56189965	2	2	241	1	0	0	0	0	0	0	0	1	17588	1606	56	5		5	ZBP1	20	56189965	Silent	SNP	T	TCGA-CV-7253-01A-11D-2012-08	25285931	56189965	6835555	213	44364											
KRTAP13-2	337959	broad.mit.edu	37	chr21	31744004	31744004	+	Nonstop_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcttaaaaggtctggaaatTcagcaagttgatctgcagaa	14	11	10	6	0	3	2	1	1	2	1	3	3	3	3	0	2	3	4	0	2	5	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr21:31744004T>A	uc002ynz.3	-	1	554	c.528A>T	c.(526-528)TGA>TGT	p.*176C		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	176						intermediate filament					0						GTCTGGAAATTCAGCAAGTTG	0.468													4	53					0	0	0	0	A	31744004	A	A	31744004	4	1	241	1	0	0	0	0	0	0	0	0	8562	1796	62	5	3	5	KRTAP13-2	21	31744004	Nonstop_Mutation	SNP	T	TCGA-CV-7253-01A-11D-2012-08		31744004	16385891	214	44365											
RIPK4	54101	broad.mit.edu	37	chr21	43166897	43166898	+	Frame_Shift_Ins	INS	-	A	A																															cggggcggtggcccttcaccINSaccttcaccatgatgtgcag																										TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chr21:43166897_43166898insA	uc002yzn.1	-	5	755_756	c.707_708insT	c.(706-708)GTGfs	p.V236fs		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	236						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GGCCCTTCACCACCTTCACCAT	0.663													---	---	---								A	43166898	A	A	43166897	7	5	241	1	0	1	1	0	0	0	0	0	13448	581	21	0	1662	0	RIPK4	21	43166897	Frame_Shift_Ins	INS	-	TCGA-CV-7253-01A-11D-2012-08	11422893	43166897	4962998	215	44366											
KDM6A	7403	broad.mit.edu	37	chrX	44942704	44942704	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgatgtgttattttattgcaGgtggaagttgcagctacatg	9	16	12	4	0	0	1	0	1	0	0	0	2	0	2	0	2	4	5	0	2	4	6			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chrX:44942704G>A	uc004dge.3	+	23	3660	c.3285_splice	c.e23-1	p.K1095_splice	KDM6A_uc011mkz.1_Splice_Site_p.K1147_splice|KDM6A_uc011mla.1_Splice_Site_p.K1050_splice|KDM6A_uc011mlb.1_Splice_Site_p.K1102_splice|KDM6A_uc011mlc.1_Splice_Site_p.K799_splice|KDM6A_uc011mld.1_Splice_Site_p.K734_splice	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TTTTATTGCAGGTGGAAGTTG	0.393			D|N|F|S		renal|oesophageal SCC|MM								8	2					0	0	0	0	A	44942704	A	A	44942704	5	1	241	1	0	0	0	0	0	0	1	0	8176	1014	35	4	3374	4	KDM6A	23	44942704	Splice_Site	SNP	G	TCGA-CV-7253-01A-11D-2012-08		44942704	110327856	216	44367											
TAF1	6872	broad.mit.edu	37	chrX	70674608	70674608	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtatgatgaacatttgacTcaacttgagaaggatatttg	14	13	9	5	0	1	4	1	4	0	1	1	6	1	5	0	1	2	1	0	1	5	5			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chrX:70674608T>C	uc004dzu.3	+	34	4887	c.4836T>C	c.(4834-4836)ACT>ACC	p.T1612T	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Silent_p.T1633T|TAF1_uc004dzv.3_Silent_p.T786T|TAF1_uc010nld.1_RNA|TAF1_uc010nle.1_RNA|TAF1_uc010nlf.1_Silent_p.T37T|TAF1_uc004dzx.2_RNA|TAF1_uc004dzy.2_RNA|TAF1_uc004dzw.1_RNA	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1612	Interaction with ASF1A and ASF1B.|Protein kinase 2.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AACATTTGACTCAACTTGAGA	0.318													13	3					0	0	0	0	C	70674608	C	C	70674608	2	2	241	1	0	0	0	0	0	0	0	1	15579	1538	54	5		5	TAF1	23	70674608	Silent	SNP	T	TCGA-CV-7253-01A-11D-2012-08	25731904	70674608	84595952	217	44368											
ARMCX5	64860	broad.mit.edu	37	chrX	101857289	101857289	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagggaggctatggctgtgAcaagggaagtgatcaaggtg	12	7	17	5	0	1	2	1	2	0	0	1	4	1	4	0	5	0	2	0	5	4	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chrX:101857289A>T	uc004ejg.2	+	6	1101	c.220A>T	c.(220-222)ACA>TCA	p.T74S	ARMCX5_uc004ejh.2_Missense_Mutation_p.T74S	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	74							binding			ovary(1)	1						TATGGCTGTGACAAGGGAAGT	0.483													26	25					0	0	0	0	T	101857289	T	T	101857289	3	4	241	1	0	0	0	0	1	0	0	0	964	275	10	5	222	5	ARMCX5	23	101857289	Missense_Mutation	SNP	A	TCGA-CV-7253-01A-11D-2012-08	31182681	101857289	53413271	218	44369											
COL4A6	1288	broad.mit.edu	37	chrX	107413937	107413937	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctcctctcatgccggcaactCctggaaatcctaaatgtgaa	11	10	7	13	1	1	1	1	1	1	0	5	2	4	2	4	2	2	1	4	2	5	1			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chrX:107413937C>G	uc004enw.3	-	35	3501	c.3398G>C	c.(3397-3399)GGA>GCA	p.G1133A	COL4A6_uc004env.3_Missense_Mutation_p.G1132A|COL4A6_uc011msn.1_Missense_Mutation_p.G1132A|COL4A6_uc010npk.2_Missense_Mutation_p.G1132A	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1133	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						GCCGGCAACTCCTGGAAATCC	0.493									Alport_syndrome_with_Diffuse_Leiomyomatosis				21	78					0	0	0	0	G	107413937	G	G	107413937	3	3	241	1	0	0	0	0	1	0	0	0	3710	855	30	2	1721	2	COL4A6	23	107413937	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	5556648	107413937	47856623	219	44370											
GLUD2	2747	broad.mit.edu	37	chrX	120182629	120182629	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattctgggcttccccaaggCaaagccctatgaaggaagca	12	7	10	12	0	1	1	0	1	1	0	2	2	2	2	3	3	2	3	3	3	5	3			TCGA-CV-7253-01A-11D-2012-08	TCGA-CV-7253-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	d501a7e5-70e7-4f80-851a-efe8859d603a	38151a65-170a-475a-8862-3e2ba2d158da	g.chrX:120182629C>A	uc004eto.2	+	1	1168	c.1091C>A	c.(1090-1092)GCA>GAA	p.A364E		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	364					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	TTCCCCAAGGCAAAGCCCTAT	0.493													85	33					1.3515e-34	1.76104e-34	1	0	A	120182629	A	A	120182629	3	1	241	1	0	0	0	0	1	0	0	0	6514	710	25	4	1093	4	GLUD2	23	120182629	Missense_Mutation	SNP	C	TCGA-CV-7253-01A-11D-2012-08	12768692	120182629	35087931	220	44371											
TTLL10	254173	broad.mit.edu	37	chr1	1120451	1120451	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacacgttctggaaggccCggggcctcgccaaggactgg	7	6	16	12	3	1	1	0	1	1	0	2	3	1	3	3	6	0	1	3	6	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:1120451C>A	uc001acy.2	+	13	1514	c.1363C>A	c.(1363-1365)CGG>AGG	p.R455R	TTLL10_uc010nyg.1_Silent_p.R455R|TTLL10_uc001acz.1_Silent_p.R382R	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	455	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CTGGAAGGCCCGGGGCCTCGC	0.612													14	14					9.31168e-06	2.40048e-05	1	0	A	1120451	A	A	1120451	2	1	242	1	0	0	0	0	0	0	0	1	16791	643	23	3		3	TTLL10	1	1120451	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08		1120451	248130170	1	44372											
EIF2C3	192669	broad.mit.edu	37	chr1	36509068	36509068	+	Frame_Shift_Del	DEL	C	-	-																															gttggaagaagtggcaatatCccagctggaacaacagttga																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:36509068delC	uc001bzp.2	+	17	2449	c.2193delC	c.(2191-2193)ATCfs	p.I731fs	EIF2C3_uc001bzq.2_Frame_Shift_Del_p.I497fs	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	731	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTGGCAATATCCCAGCTGGAA	0.353													---	---	---								-	36509068	-	-	36509068	7	5	242	1	0	1	0	1	0	0	0	0	5029	845	30	0	2259	0	EIF2C3	1	36509068	Frame_Shift_Del	DEL	C	TCGA-CV-7254-01A-11D-2012-08	35388617	36509068	212741553	2	44373											
FPGT	8790	broad.mit.edu	37	chr1	74670983	74670983	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttctgtggcacctggctcaGttgtggagtattccagattg	6	14	13	8	0	2	1	1	0	1	1	3	2	3	2	2	3	0	5	2	3	1	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:74670983G>T	uc001dgb.1	+	4	1289	c.1252G>T	c.(1252-1254)GTT>TTT	p.V418F	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Missense_Mutation_p.V43F|FPGT_uc010oqu.1_Missense_Mutation_p.V164F|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	418					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						ACCTGGCTCAGTTGTGGAGTA	0.433													44	52					9.39024e-22	2.99432e-21	1	0	T	74670983	T	T	74670983	3	4	242	1	0	0	0	0	1	0	0	0	6071	1029	36	4	1266	4	FPGT	1	74670983	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	38161915	74670983	174579638	3	44374											
NEXN	91624	broad.mit.edu	37	chr1	78390878	78390878	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attctcattcaatagattgaGgacataaacaatacgggaac	17	10	7	7	1	2	2	2	1	1	1	3	4	2	4	0	2	3	0	0	2	7	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:78390878G>A	uc001dic.3	+	6	750	c.453G>A	c.(451-453)GAG>GAA	p.E151E	NEXN_uc001dia.3_Intron|NEXN_uc009wcb.1_Intron|NEXN_uc001dib.3_Silent_p.E87E|NEXN_uc001did.1_Intron|NEXN_uc001dif.1_Silent_p.E43E	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	151	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		AATAGATTGAGGACATAAACA	0.289													4	9					0	0	0	0	A	78390878	A	A	78390878	2	1	242	1	0	0	0	0	0	0	0	1	10409	991	35	4		4	NEXN	1	78390878	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	3719895	78390878	170859743	4	44375											
VAV3	10451	broad.mit.edu	37	chr1	108247231	108247231	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacattctttgtgtgctctcGctccacacttaaaacataaa	13	13	4	11	1	2	0	0	0	2	0	4	0	3	0	1	0	3	2	1	0	5	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:108247231G>A	uc001dvk.1	-	17	1700	c.1646C>T	c.(1645-1647)GCG>GTG	p.A549V	VAV3_uc010ouw.1_Missense_Mutation_p.A549V|VAV3_uc001dvl.1_Missense_Mutation_p.A373V|VAV3_uc010oux.1_Missense_Mutation_p.A549V	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	549	Phorbol-ester/DAG-type.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		GTGTGCTCTCGCTCCACACTT	0.358													19	26					0	0	0	0	A	108247231	A	A	108247231	3	1	242	1	0	0	0	0	1	0	0	0	17201	1087	38	1	966	1	VAV3	1	108247231	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	29856353	108247231	141003390	5	44376											
CELSR2	1952	broad.mit.edu	37	chr1	109815846	109815858	+	Frame_Shift_Del	DEL	AGAGAGTAGTGGC	-	-																															gactttgggaccacagcaaaAgagagtagtggcaacggggc																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:109815846_109815858delAGAGAGTAGTGGC	uc001dxa.3	+	32	8458_8470	c.8397_8409delAGAGAGTAGTGGC	c.(8395-8409)AAAGAGAGTAGTGGCfs	p.K2799fs		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2799_2803	Cytoplasmic (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCACAGCAAAAGAGAGTAGTGGCAACGGGGCCC	0.638													---	---	---								-	109815858	-	-	109815846	7	5	242	1	0	1	0	1	0	0	0	0	3237	69	3	0	8523	0	CELSR2	1	109815846	Frame_Shift_Del	DEL	AGAGAGTAGTGGC	TCGA-CV-7254-01A-11D-2012-08	1568615	109815846	139434775	6	44377											
PTGFRN	5738	broad.mit.edu	37	chr1	117504234	117504234	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaacagcggaacaacagctGggtgaaaagcaaggatgtct	16	5	12	8	1	1	1	0	1	1	0	1	3	1	3	0	3	6	2	0	3	6	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:117504234G>T	uc001egv.1	+	5	1720	c.1583G>T	c.(1582-1584)TGG>TTG	p.W528L		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	528	Extracellular (Potential).|Ig-like C2-type 4.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		AACAACAGCTGGGTGAAAAGC	0.413													19	26					1.45105e-14	4.41431e-14	1	0	T	117504234	T	T	117504234	3	4	242	1	0	0	0	0	1	0	0	0	12813	1357	47	4	1601	4	PTGFRN	1	117504234	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	7688388	117504234	131746387	7	44378											
ANP32E	81611	broad.mit.edu	37	chr1	150202958	150202958	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtttccactcagattgaggTaggtaagatttggacatttc	10	15	10	6	0	1	3	1	1	0	2	3	4	2	4	1	3	0	3	1	3	2	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:150202958T>G	uc001etw.2	-	3	645	c.275A>C	c.(274-276)TAC>TCC	p.Y92S	ANP32E_uc010pbu.1_Missense_Mutation_p.Y44S|ANP32E_uc010pbv.1_Intron|ANP32E_uc001etv.3_Missense_Mutation_p.Y92S|ANP32E_uc010pbw.1_Missense_Mutation_p.Y92S	NM_030920	NP_112182	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	92	LRR 4.					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity				0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGATTGAGGTAGGTAAGATT	0.358													4	43					0	0	0	0	G	150202958	G	G	150202958	3	3	242	1	0	0	0	0	1	0	0	0	709	1638	57	5	551	5	ANP32E	1	150202958	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	32698724	150202958	99047663	8	44379											
FLG	2312	broad.mit.edu	37	chr1	152277899	152277899	+	Frame_Shift_Del	DEL	G	-	-																															tgcacttctggatcctgactGcccacgggaggcatcagacc																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:152277899delG	uc001ezu.1	-	3	9499	c.9463delC	c.(9463-9465)CAGfs	p.Q3155fs		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3155	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATCCTGACTGCCCACGGGAG	0.557									Ichthyosis				---	---	---								-	152277899	-	-	152277899	7	5	242	1	0	1	0	1	0	0	0	0	5954	1328	46	0	2726	0	FLG	1	152277899	Frame_Shift_Del	DEL	G	TCGA-CV-7254-01A-11D-2012-08	2074941	152277899	96972722	9	44380			1	68		3	3	1035	N	G_C	4.883452e-05
FLG	2312	broad.mit.edu	37	chr1	152278871	152278871	+	Frame_Shift_Del	DEL	G	-	-																															tgcacttctggatcctgactGcccacgggaggcatcagacc																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:152278871delG	uc001ezu.1	-	3	8527	c.8491delC	c.(8491-8493)CAGfs	p.Q2831fs		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2831	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATCCTGACTGCCCACGGGAG	0.572									Ichthyosis				---	---	---								-	152278871	-	-	152278871	7	5	242	1	0	1	0	1	0	0	0	0	5954	1328	46	0	3698	0	FLG	1	152278871	Frame_Shift_Del	DEL	G	TCGA-CV-7254-01A-11D-2012-08	972	152278871	96971750	10	44381			1	68		3	3	1035	N	G_C	4.883452e-05
FLG	2312	broad.mit.edu	37	chr1	152278933	152278933	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtgatgggaccctgagtgtCcagagctatctaccgaatgc	9	10	12	10	1	1	3	0	2	1	1	2	5	2	4	3	1	3	1	3	1	3	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:152278933C>A	uc001ezu.1	-	3	8465	c.8429G>T	c.(8428-8430)GGA>GTA	p.G2810V		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2810	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTGAGTGTCCAGAGCTATC	0.577									Ichthyosis				66	472					1.77486e-58	5.8964e-58	1	0	A	152278933	A	A	152278933	3	1	242	1	0	0	0	0	1	0	0	0	5954	855	30	2	3760	2	FLG	1	152278933	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	62	152278933	96971688	11	44382			1	68		3	3	1035	N	G_C	4.883452e-05
LCE3A	353142	broad.mit.edu	37	chr1	152595358	152595358	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagctggagctcccgccttgCtgaccacttcccctgtcaca	6	9	8	18	1	1	1	1	1	0	0	3	2	3	2	5	1	3	3	5	1	0	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:152595358C>T	uc010pdt.1	-	1	222	c.222G>A	c.(220-222)CAG>CAA	p.Q74Q		NM_178431	NP_848518	Q5TA76	LCE3A_HUMAN	late cornified envelope 3A	74					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCCGCCTTGCTGACCACTTC	0.567													15	108					0	0	0	0	T	152595358	T	T	152595358	2	4	242	1	0	0	0	0	0	0	0	1	8709	796	28	4		4	LCE3A	1	152595358	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	316425	152595358	96655263	12	44383											
FCRL4	83417	broad.mit.edu	37	chr1	157557331	157557331	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgagagtctgtagctttcagCtctggatgtggaaatagttc	9	14	12	6	0	3	1	1	1	2	1	4	4	3	3	0	2	2	4	0	2	3	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:157557331C>A	uc001fqw.2	-	5	718	c.582G>T	c.(580-582)GAG>GAT	p.E194D	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	194	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				TAGCTTTCAGCTCTGGATGTG	0.483													13	125					0.000151284	0.000373043	1	0	A	157557331	A	A	157557331	3	1	242	1	0	0	0	0	1	0	0	0	5829	796	28	4	997	4	FCRL4	1	157557331	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	4961973	157557331	91693290	13	44384											
FCRL2	79368	broad.mit.edu	37	chr1	157740241	157740241	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttgaagttttatcccagaGaaagagttgtcctttggtac	11	15	9	6	0	0	3	0	1	0	2	2	4	2	3	2	1	1	3	2	1	4	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:157740241G>A	uc001fre.2	-	3	327	c.268C>T	c.(268-270)CTC>TTC	p.L90F	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.L90F|FCRL2_uc009wsp.2_Missense_Mutation_p.L90F|FCRL2_uc010pia.1_Missense_Mutation_p.L90F	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	90	Ig-like C2-type 1.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTATCCCAGAGAAAGAGTTGT	0.403													14	62					0	0	0	0	A	157740241	A	A	157740241	3	1	242	1	0	0	0	0	1	0	0	0	5827	942	33	2	1298	2	FCRL2	1	157740241	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	182910	157740241	91510380	14	44385											
ATF6	22926	broad.mit.edu	37	chr1	161789450	161789450	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctaaggagacagcaacgtAtgataaaaaatcgagaatcc	18	7	9	7	2	0	3	0	1	0	2	2	5	1	3	1	1	3	3	1	1	7	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:161789450A>G	uc001gbr.2	+	8	1004	c.937A>G	c.(937-939)ATG>GTG	p.M313V	ATF6_uc001gbq.1_Missense_Mutation_p.M313V	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	313	Basic motif.|Cytoplasmic (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			ACAGCAACGTATGATAAAAAA	0.368													4	54					0	0	0	0	G	161789450	G	G	161789450	3	3	242	1	0	0	0	0	1	0	0	0	1086	449	16	5	967	5	ATF6	1	161789450	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	4049209	161789450	87461171	15	44386											
MGST3	4259	broad.mit.edu	37	chr1	165624685	165624686	+	Missense_Mutation	DNP	CA	AT	AT																															caactgtgtgctctgctttcCagcatcttggttgggttaaa																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:165624685_165624686CA>AT	uc001gdf.2	+	6	491_492	c.403_404CA>AT	c.(403-405)CAG>ATG	p.Q135M	MGST3_uc001gdg.2_Missense_Mutation_p.Q149M	NM_004528	NP_004519	O14880	MGST3_HUMAN	microsomal glutathione S-transferase 3	135	Helical; (Potential).				leukotriene biosynthetic process|leukotriene production involved in inflammatory response|signal transduction|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glutathione peroxidase activity|glutathione transferase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Glutathione(DB00143)	CTCTGCTTTCCAGCATCTTGGT	0.47													12	34					0	0	0	0	AT	165624686	AT	AT	165624685	3	1	242	1	0	0	0	0	1	0	0	0	9615	595	21	4	421	4	MGST3	1	165624685	Missense_Mutation	DNP	CA	TCGA-CV-7254-01A-11D-2012-08	3835235	165624685	83625936	16	44387											
C1orf114	57821	broad.mit.edu	37	chr1	169390781	169390781	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttggacaagtcttgcggttGagtggtggctgagcgatata	8	12	15	6	2	1	2	0	2	1	0	1	4	1	3	0	4	2	2	0	4	3	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:169390781G>C	uc001gga.1	-	3	1056	c.888C>G	c.(886-888)CTC>CTG	p.L296L	C1orf114_uc001gfz.1_Silent_p.L296L|C1orf114_uc009wvq.1_Silent_p.L296L|C1orf114_uc001ggb.2_Silent_p.L296L|C1orf114_uc001ggc.1_Silent_p.L296L	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	296											0	all_hematologic(923;0.208)					TCTTGCGGTTGAGTGGTGGCT	0.478													45	117					0	0	0	0	C	169390781	C	C	169390781	2	2	242	1	0	0	0	0	0	0	0	1	1996	1277	45	2		2	C1orf114	1	169390781	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	3766096	169390781	79859840	17	44388											
F5	2153	broad.mit.edu	37	chr1	169512317	169512317	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagcctcagctttttgcttcTtggactagaattcatggaag	9	14	9	9	0	3	1	2	0	1	1	3	3	3	3	1	2	3	2	1	2	3	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:169512317T>C	uc001ggg.1	-	13	2156	c.2011A>G	c.(2011-2013)AGA>GGA	p.R671G		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	671	Plastocyanin-like 4.|F5/8 type A 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTTTTGCTTCTTGGACTAGAA	0.383													19	52					0	0	0	0	C	169512317	C	C	169512317	3	2	242	1	0	0	0	0	1	0	0	0	5373	1617	56	5	4715	5	F5	1	169512317	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	121536	169512317	79738304	18	44389											
FAM5C	339479	broad.mit.edu	37	chr1	190423907	190423907	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcgaaggggcttgtggcatgCtgatccgaaacagcagcaac	11	7	13	10	2	0	1	0	1	0	0	2	3	1	1	1	3	5	5	1	3	3	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:190423907C>T	uc001gse.1	-	2	346	c.114G>A	c.(112-114)CAG>CAA	p.Q38Q	FAM5C_uc010pot.1_5'UTR	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	38						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TTGTGGCATGCTGATCCGAAA	0.517													13	31					0	0	0	0	T	190423907	T	T	190423907	2	4	242	1	0	0	0	0	0	0	0	1	5626	796	28	4		4	FAM5C	1	190423907	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	20911590	190423907	58826714	19	44390											
F13B	2165	broad.mit.edu	37	chr1	197024991	197024991	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtctgcaacagccccattcAttacaacaggaggatgctta	12	9	8	12	1	2	0	1	0	1	0	2	2	2	2	2	2	6	2	2	2	4	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:197024991A>T	uc001gtt.1	-	8	1252	c.1208T>A	c.(1207-1209)ATG>AAG	p.M403K		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	403	Sushi 7.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AGCCCCATTCATTACAACAGG	0.343													4	56					0	0	0	0	T	197024991	T	T	197024991	3	4	242	1	0	0	0	0	1	0	0	0	5366	217	8	5	797	5	F13B	1	197024991	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	6601084	197024991	52225630	20	44391											
ASPM	259266	broad.mit.edu	37	chr1	197071613	197071613	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatcatttttaaatgtctTctagctttctttcccctaaa	9	19	3	10	0	4	0	1	0	3	0	5	0	5	0	2	0	2	2	2	0	5	8			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:197071613T>A	uc001gtu.2	-	18	7025	c.6768A>T	c.(6766-6768)AGA>AGT	p.R2256S	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.R104S	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2256	IQ 20.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTAAATGTCTTCTAGCTTTCT	0.348													25	127					0	0	0	0	A	197071613	A	A	197071613	3	1	242	1	0	0	0	0	1	0	0	0	1058	1780	62	5	3709	5	ASPM	1	197071613	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	46622	197071613	52179008	21	44392											
FAM58B	339521	broad.mit.edu	37	chr1	200183360	200183360	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgagaagctgtggtggcaGgcgtttagtgacgaccttac	8	10	15	8	2	0	2	0	2	0	1	0	4	0	2	1	3	2	4	1	3	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:200183360G>C	uc009wzi.1	+	1	705	c.669G>C	c.(667-669)CAG>CAC	p.Q223H		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	223					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					TGTGGTGGCAGGCGTTTAGTG	0.547													16	75					0	0	0	0	C	200183360	C	C	200183360	3	2	242	1	0	0	0	0	1	0	0	0	5623	991	35	4	671	4	FAM58B	1	200183360	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	3111747	200183360	49067261	22	44393											
KIF14	9928	broad.mit.edu	37	chr1	200522870	200522870	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atactttcaacacaagtctgGagaagatttatatcactatg	15	13	6	7	0	3	2	2	0	1	2	3	3	3	2	0	1	2	0	0	1	7	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:200522870G>A	uc010ppk.1	-	30	5032	c.4593C>T	c.(4591-4593)CTC>CTT	p.L1531L	KIF14_uc010ppj.1_Silent_p.L1040L	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1531	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						CACAAGTCTGGAGAAGATTTA	0.383													15	54					0	0	0	0	A	200522870	A	A	200522870	2	1	242	1	0	0	0	0	0	0	0	1	8315	1161	41	2		2	KIF14	1	200522870	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	339510	200522870	48727751	23	44394											
C1orf186	440712	broad.mit.edu	37	chr1	206243246	206243247	+	Frame_Shift_Ins	INS	-	G	G																															aagccatgccagacctccatINSgactctgttgggaaagaaaa																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:206243246_206243247insG	uc001hdt.1	-	3	654_655	c.15_16insC	c.(13-18)GTCATGfs	p.V5fs		NM_001007544	NP_001007545	Q6ZWK4	CA186_HUMAN	hypothetical protein LOC440712	5_6						integral to membrane					0			BRCA - Breast invasive adenocarcinoma(75;0.0754)			CAGACCTCCATGACTCTGTTGG	0.332													---	---	---								G	206243247	G	G	206243246	7	5	242	1	0	1	1	0	0	0	0	0	2029	1464	51	0	518	0	C1orf186	1	206243246	Frame_Shift_Ins	INS	-	TCGA-CV-7254-01A-11D-2012-08	5720376	206243246	43007375	24	44395											
CR1	1378	broad.mit.edu	37	chr1	207755303	207755303	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccgttagtcattgtgtcttgGttggaatgagaagcctttgg	7	15	13	6	1	2	1	1	1	1	1	2	3	2	2	2	3	1	2	2	3	3	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:207755303G>T	uc001hfy.2	+	24	4047	c.3907G>T	c.(3907-3909)GTT>TTT	p.V1303F	CR1_uc009xcl.1_Missense_Mutation_p.V853F|CR1_uc001hfx.2_Missense_Mutation_p.V1753F	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1303	Sushi 20.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TTGTGTCTTGGTTGGAATGAG	0.408													23	76					2.41591e-17	7.58195e-17	1	0	T	207755303	T	T	207755303	3	4	242	1	0	0	0	0	1	0	0	0	3855	1261	44	4	5383	4	CR1	1	207755303	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1512057	207755303	41495318	25	44396											
KCNH1	3756	broad.mit.edu	37	chr1	211192294	211192294	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgtcttcaggtagttcatgCggataagtttggggtcagaa	10	12	13	6	2	4	1	3	0	1	1	4	2	4	2	0	4	1	3	0	4	3	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:211192294C>T	uc001hib.2	-	6	1033	c.863G>A	c.(862-864)CGC>CAC	p.R288H	KCNH1_uc001hic.2_Missense_Mutation_p.R288H	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	288	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GTAGTTCATGCGGATAAGTTT	0.448													31	97					0	0	0	0	T	211192294	T	T	211192294	3	4	242	1	0	0	0	0	1	0	0	0	8070	768	27	1	2130	1	KCNH1	1	211192294	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	3436991	211192294	38058327	26	44397											
PROX1	5629	broad.mit.edu	37	chr1	214171271	214171271	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcggccaccaccagcccctgCaccagtcgcctctctctgcc	5	6	8	22	2	2	0	0	0	2	0	4	0	2	0	8	1	3	1	8	1	0	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:214171271C>A	uc001hkh.2	+	2	1665	c.1393C>A	c.(1393-1395)CAC>AAC	p.H465N	PROX1_uc001hkg.1_Missense_Mutation_p.H465N	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	465					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CCAGCCCCTGCACCAGTCGCC	0.632													15	144					7.93312e-07	2.11372e-06	1	0	A	214171271	A	A	214171271	3	1	242	1	0	0	0	0	1	0	0	0	12622	710	25	4	1395	4	PROX1	1	214171271	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	2978977	214171271	35079350	27	44398											
USH2A	7399	broad.mit.edu	37	chr1	216258196	216258196	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atgtacatccttgagacagcCcacaaaacctttttggatta	13	12	6	10	0	0	1	0	1	0	1	1	3	1	2	3	1	3	1	3	1	4	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:216258196C>A	uc001hku.1	-	25	5398	c.5011G>T	c.(5011-5013)GGC>TGC	p.G1671C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1671	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTGAGACAGCCCACAAAACCT	0.323										HNSCC(13;0.011)			27	78					4.7796e-09	1.35054e-08	1	0	A	216258196	A	A	216258196	3	1	242	1	0	0	0	0	1	0	0	0	17104	623	22	4	10789	4	USH2A	1	216258196	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	2086925	216258196	32992425	28	44399											
DISP1	84976	broad.mit.edu	37	chr1	223116610	223116610	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccctctccatccttctgcCtgcatcatccgtggcctgac	5	11	7	18	1	3	1	1	1	2	0	6	1	5	1	6	1	3	1	6	1	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:223116610C>T	uc001hnu.1	+	2	592	c.445C>T	c.(445-447)CTG>TTG	p.L149L		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	149					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		ATCCTTCTGCCTGCATCATCC	0.473													24	85					0	0	0	0	T	223116610	T	T	223116610	2	4	242	1	0	0	0	0	0	0	0	1	4561	680	24	4		4	DISP1	1	223116610	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	6858414	223116610	26134011	29	44400											
TRIM67	440730	broad.mit.edu	37	chr1	231333150	231333150	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggccttaaatggagtttcaGataaggcaaaggaagcaaag	17	7	12	5	0	1	1	1	0	0	1	1	3	1	3	1	4	1	3	1	4	6	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:231333150G>C	uc009xfn.1	+	2	1120	c.1078G>C	c.(1078-1080)GAT>CAT	p.D360H		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	360	Potential.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				TGGAGTTTCAGATAAGGCAAA	0.408													25	60					0	0	0	0	C	231333150	C	C	231333150	3	2	242	1	0	0	0	0	1	0	0	0	16607	942	33	2	1084	2	TRIM67	1	231333150	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	8216540	231333150	17917471	30	44401											
FMN2	56776	broad.mit.edu	37	chr1	240371752	240371752	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccacctcctcccttgccaGgtatggggattccacctgct	5	10	8	18	0	0	0	0	0	0	0	3	1	3	1	8	3	2	2	8	3	1	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:240371752G>T	uc010pyd.1	+	5	3865	c.3640G>T	c.(3640-3642)GGT>TGT	p.G1214C	FMN2_uc010pye.1_Missense_Mutation_p.G1218C	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1214	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCCCTTGCCAGGTATGGGGAT	0.647													6	25					8.12818e-05	0.000202949	1	0	T	240371752	T	T	240371752	3	4	242	1	0	0	0	0	1	0	0	0	5982	1000	35	4	3658	4	FMN2	1	240371752	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	9038602	240371752	8878869	31	44402											
KIF26B	55083	broad.mit.edu	37	chr1	245848773	245848773	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcatgcgcaggcccacccagCtgagacccttccacaccagg	9	4	10	18	1	0	1	0	1	0	1	1	2	1	1	5	2	2	3	5	2	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:245848773C>T	uc001ibf.1	+	12	2928	c.2488C>T	c.(2488-2490)CTG>TTG	p.L830L	KIF26B_uc001ibg.1_Silent_p.L448L|KIF26B_uc001ibh.1_Silent_p.L72L	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	830					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GCCCACCCAGCTGAGACCCTT	0.642													10	42					0	0	0	0	T	245848773	T	T	245848773	2	4	242	1	0	0	0	0	0	0	0	1	8334	796	28	4		4	KIF26B	1	245848773	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	5477021	245848773	3401848	32	44403											
OR2T11	127077	broad.mit.edu	37	chr1	248789867	248789867	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtttcatacaaggacgtgTctgcacaggccagtttcaga	11	10	11	9	1	3	1	2	0	1	1	3	3	3	2	1	2	2	3	1	2	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr1:248789867T>A	uc001ier.1	-	1	563	c.563A>T	c.(562-564)GAC>GTC	p.D188V		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAAGGACGTGTCTGCACAGGC	0.478													32	30					0	0	0	0	A	248789867	A	A	248789867	3	1	242	1	0	0	0	0	1	0	0	0	11072	1667	58	5	391	5	OR2T11	1	248789867	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	2941094	248789867	460754	33	44404											
ATP6V1C2	245973	broad.mit.edu	37	chr2	10912735	10912738	+	Splice_Site	DEL	AAGT	-	-																															tggtggtccctcgatcaaccAagtaagtgagaccccagctt																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:10912735_10912738delAAGT	uc002ras.2	+	8	747	c.638_splice	c.e8+1	p.K213_splice	ATP6V1C2_uc002rat.2_Splice_Site_p.K213_splice	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	vacuolar H+ ATPase C2 isoform a						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		TCGATCAACCAAGTAAGTGAGACC	0.525													---	---	---								-	10912738	-	-	10912735	8	5	242	1	0	1	0	1	0	0	1	0	1183	144	5	0	663	0	ATP6V1C2	2	10912735	Splice_Site	DEL	AAGT	TCGA-CV-7254-01A-11D-2012-08		10912735	232286638	34	44405											
GREB1	9687	broad.mit.edu	37	chr2	11696796	11696796	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgctttgaagaggtcttgcAcaattccatcgaggcatccc	10	10	9	12	2	1	2	0	1	1	1	4	3	3	2	2	2	1	3	2	2	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:11696796A>G	uc002rbk.1	+	2	356	c.56A>G	c.(55-57)CAC>CGC	p.H19R	GREB1_uc002rbl.2_Missense_Mutation_p.H19R|GREB1_uc002rbm.2_Intron|GREB1_uc002rbn.1_Missense_Mutation_p.H19R	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	19						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GAGGTCTTGCACAATTCCATC	0.512													31	69					0	0	0	0	G	11696796	G	G	11696796	3	3	242	1	0	0	0	0	1	0	0	0	6799	159	6	5	58	5	GREB1	2	11696796	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	784061	11696796	231502577	35	44406											
GREB1	9687	broad.mit.edu	37	chr2	11696840	11696840	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccaacaacctggtgcccAggcccatcttttcccagctg	7	9	9	16	0	1	0	0	0	1	0	3	0	3	0	5	3	4	1	5	3	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:11696840A>T	uc002rbk.1	+	2	400	c.100A>T	c.(100-102)AGG>TGG	p.R34W	GREB1_uc002rbl.2_Missense_Mutation_p.R34W|GREB1_uc002rbm.2_Intron|GREB1_uc002rbn.1_Missense_Mutation_p.R34W	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	34						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CCTGGTGCCCAGGCCCATCTT	0.517													13	57					0	0	0	0	T	11696840	T	T	11696840	3	4	242	1	0	0	0	0	1	0	0	0	6799	179	7	5	102	5	GREB1	2	11696840	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	44	11696840	231502533	36	44407											
APOB	338	broad.mit.edu	37	chr2	21230159	21230159	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctctgactgataaactcaCaaagcacagccaaaggattt	15	9	7	10	0	2	2	1	2	1	0	2	3	2	3	1	1	4	2	1	1	4	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:21230159C>A	uc002red.2	-	26	9709	c.9581G>T	c.(9580-9582)TGT>TTT	p.C3194F		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3194	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATAAACTCACAAAGCACAGC	0.328													20	41					4.96729e-08	1.36945e-07	1	0	A	21230159	A	A	21230159	3	1	242	1	0	0	0	0	1	0	0	0	785	478	17	4	4126	4	APOB	2	21230159	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	9533319	21230159	221969214	37	44408											
APOB	338	broad.mit.edu	37	chr2	21231819	21231819	+	Frame_Shift_Del	DEL	T	-	-																															tgtggaaaacctggatgggaTttttatattttttaagtctt																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:21231819delT	uc002red.2	-	26	8049	c.7921delA	c.(7921-7923)ATCfs	p.I2641fs		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2641					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTGGATGGGATTTTTATATTT	0.358													---	---	---								-	21231819	-	-	21231819	7	5	242	1	0	1	0	1	0	0	0	0	785	1493	52	0	5786	0	APOB	2	21231819	Frame_Shift_Del	DEL	T	TCGA-CV-7254-01A-11D-2012-08	1660	21231819	221967554	38	44409											
ADCY3	109	broad.mit.edu	37	chr2	25048966	25048966	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggaacaccatcaccgtcAtagagtacttggaaggcacc	13	7	10	11	1	2	2	2	1	0	1	2	4	2	4	3	3	2	2	3	3	4	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:25048966A>T	uc002rfs.3	-	15	2724	c.2525T>A	c.(2524-2526)ATG>AAG	p.M842K	ADCY3_uc002rfr.3_Missense_Mutation_p.M429K|ADCY3_uc010ykm.1_Missense_Mutation_p.M843K	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	842	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					CATCACCGTCATAGAGTACTT	0.612													7	29					0	0	0	0	T	25048966	T	T	25048966	3	4	242	1	0	0	0	0	1	0	0	0	295	217	8	5	937	5	ADCY3	2	25048966	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	3817147	25048966	218150407	39	44410											
C2orf16	84226	broad.mit.edu	37	chr2	27800686	27800686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggctacaaatggaggaatCtttagaggtgcccctgaagc	12	9	12	8	0	1	2	0	1	1	1	1	4	1	4	2	4	3	1	2	4	5	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:27800686C>T	uc002rkz.3	+	1	1298	c.1247C>T	c.(1246-1248)TCT>TTT	p.S416F		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	416										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					ATGGAGGAATCTTTAGAGGTG	0.473													8	70					0	0	0	0	T	27800686	T	T	27800686	3	4	242	1	0	0	0	0	1	0	0	0	2167	913	32	2	1249	2	C2orf16	2	27800686	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	2751720	27800686	215398687	40	44411											
RTN4	57142	broad.mit.edu	37	chr2	55252626	55252626	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgatcaatgtagggaacTcatctataatttcaattgga	15	13	7	6	0	4	1	3	1	1	0	4	3	4	3	0	2	2	1	0	2	7	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:55252626T>A	uc002rye.2	-	3	2907	c.2609A>T	c.(2608-2610)GAG>GTG	p.E870V	RTN4_uc002ryd.2_Missense_Mutation_p.E664V|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	870	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						TGTAGGGAACTCATCTATAAT	0.328													8	51					0	0	0	0	A	55252626	A	A	55252626	3	1	242	1	0	0	0	0	1	0	0	0	13793	1551	54	5	1035	5	RTN4	2	55252626	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	27451940	55252626	187946747	41	44412											
USP34	9736	broad.mit.edu	37	chr2	61415830	61415830	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgccgccttttaatgggagTtgctccttcatcatctgtga	7	14	9	11	2	3	1	2	1	1	0	4	2	4	2	3	1	1	2	3	1	1	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:61415830T>A	uc002sbe.2	-	80	10070	c.10048A>T	c.(10048-10050)ACT>TCT	p.T3350S	USP34_uc002sbd.2_Missense_Mutation_p.T152S	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3350					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TTAATGGGAGTTGCTCCTTCA	0.463													20	61					0	0	0	0	A	61415830	A	A	61415830	3	1	242	1	0	0	0	0	1	0	0	0	17133	1725	60	5	596	5	USP34	2	61415830	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	6163204	61415830	181783543	42	44413											
ACTG2	72	broad.mit.edu	37	chr2	74128460	74128460	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgaagaggagaccaccGcgctcgtgtgtgacaatggc	9	8	15	9	3	0	4	0	2	0	2	1	5	0	4	2	2	0	1	2	2	2	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:74128460G>A	uc002sjw.2	+	2	144	c.22G>A	c.(22-24)GCG>ACG	p.A8T	ACTG2_uc010fex.1_Missense_Mutation_p.A8T|ACTG2_uc010fey.2_Missense_Mutation_p.A8T|ACTG2_uc010yrn.1_Missense_Mutation_p.A8T	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	8					muscle contraction	cytoskeleton|cytosol	ATP binding				0						GGAGACCACCGCGCTCGTGTG	0.607													10	42					0	0	0	0	A	74128460	A	A	74128460	3	1	242	1	0	0	0	0	1	0	0	0	197	1087	38	1	24	1	ACTG2	2	74128460	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	12712630	74128460	169070913	43	44414											
REG3G	130120	broad.mit.edu	37	chr2	79254286	79254286	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatctggattgggctccatGaccccacacaggtgcgagta	10	8	11	12	1	1	1	0	1	1	0	2	3	2	2	3	3	1	2	3	3	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:79254286G>T	uc002snw.2	+	4	407	c.322G>T	c.(322-324)GAC>TAC	p.D108Y	REG3G_uc002snx.2_Missense_Mutation_p.D108Y|REG3G_uc010ffu.2_Intron	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	108	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						TGGGCTCCATGACCCCACACA	0.552													25	88					6.32553e-13	1.88815e-12	1	0	T	79254286	T	T	79254286	3	4	242	1	0	0	0	0	1	0	0	0	13278	1290	45	2	332	2	REG3G	2	79254286	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	5125826	79254286	163945087	44	44415											
REG1A	5967	broad.mit.edu	37	chr2	79349170	79349171	+	Missense_Mutation	DNP	GG	TT	TT																															tctgtgctcacccaggccgaGggtgcctttgtggcctcact																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:79349170_79349171GG>TT	uc002snz.2	+	4	343_344	c.240_241GG>TT	c.(238-243)GAGGGT>GATTGT	p.80_81EG>DC	REG1A_uc010ffx.1_3'UTR|REG1A_uc010ysd.1_Missense_Mutation_p.80_81EG>DC	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	80_81	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CCCAGGCCGAGGGTGCCTTTGT	0.515													31	106					0	0	0	0	TT	79349171	TT	TT	79349170	3	4	242	1	0	0	0	0	1	0	0	0	13275	991	35	4	250	4	REG1A	2	79349170	Missense_Mutation	DNP	GG	TCGA-CV-7254-01A-11D-2012-08	94884	79349170	163850203	45	44416											
VWA3B	200403	broad.mit.edu	37	chr2	98797619	98797619	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgctctttccgccacgctGatggggttgtggatataaaa	9	12	11	9	2	1	1	0	1	1	0	2	2	2	2	2	3	1	3	2	3	3	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:98797619G>T	uc002syo.2	+	9	1519	c.1255G>T	c.(1255-1257)GAT>TAT	p.D419Y	VWA3B_uc010yvh.1_Missense_Mutation_p.D269Y|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_5'UTR|VWA3B_uc002sym.2_Missense_Mutation_p.D419Y|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.D76Y	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	419										ovary(3)|large_intestine(2)|skin(1)	6						CCGCCACGCTGATGGGGTTGT	0.552													31	103					5.8336e-16	1.80933e-15	1	0	T	98797619	T	T	98797619	3	4	242	1	0	0	0	0	1	0	0	0	17309	1290	45	2	1285	2	VWA3B	2	98797619	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	19448449	98797619	144401754	46	44417											
VWA3B	200403	broad.mit.edu	37	chr2	98916586	98916586	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgtgatacccaaaggattTgacttctatgtccctgccat	10	14	7	10	0	1	2	0	2	1	0	2	3	2	3	3	1	2	0	3	1	3	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:98916586T>C	uc002syo.2	+	25	3591	c.3327T>C	c.(3325-3327)TTT>TTC	p.F1109F	VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Silent_p.F766F|VWA3B_uc002syp.1_Silent_p.F501F|VWA3B_uc002syq.1_Silent_p.F385F|VWA3B_uc002syr.1_Silent_p.F426F|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1109										ovary(3)|large_intestine(2)|skin(1)	6						CCAAAGGATTTGACTTCTATG	0.388													46	131					0	0	0	0	C	98916586	C	C	98916586	2	2	242	1	0	0	0	0	0	0	0	1	17309	1809	63	5		5	VWA3B	2	98916586	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08	118967	98916586	144282787	47	44418											
AFF3	3899	broad.mit.edu	37	chr2	100210206	100210206	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcacggaggagcgcagctcCttgcggtggctcgctctgtt	4	10	15	12	4	2	0	1	0	1	0	4	2	3	2	1	4	3	5	1	4	0	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:100210206C>T	uc002tag.2	-	14	2153	c.1917G>A	c.(1915-1917)AAG>AAA	p.K639K	AFF3_uc002taf.2_Silent_p.K664K|AFF3_uc010fiq.1_Silent_p.K639K|AFF3_uc010yvr.1_Silent_p.K792K|AFF3_uc002tah.1_Silent_p.K664K	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	639					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						AGCGCAGCTCCTTGCGGTGGC	0.662													14	74					0	0	0	0	T	100210206	T	T	100210206	2	4	242	1	0	0	0	0	0	0	0	1	358	680	24	4		4	AFF3	2	100210206	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	1293620	100210206	142989167	48	44419											
IL1RL1	9173	broad.mit.edu	37	chr2	102968311	102968311	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggaagcacgtgaggtaccAaatgcctgtgccaagcaaaa	14	6	11	10	1	0	1	0	1	0	0	0	2	0	2	3	2	5	3	3	2	6	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:102968311A>C	uc002tbu.1	+	11	1872	c.1601A>C	c.(1600-1602)CAA>CCA	p.Q534P	IL18R1_uc002tbw.3_Intron	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	534	TIR.|Cytoplasmic (Potential).				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GTGAGGTACCAAATGCCTGTG	0.488													15	91					0	0	0	0	C	102968311	C	C	102968311	3	2	242	1	0	0	0	0	1	0	0	0	7702	130	5	5	1656	5	IL1RL1	2	102968311	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	2758105	102968311	140231062	49	44420											
DPP10	57628	broad.mit.edu	37	chr2	116535404	116535404	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcccagaggaaggcagcTgtacaggtaagcagtgtgca	11	8	13	9	0	1	1	0	0	1	1	2	2	1	2	1	3	4	6	1	3	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:116535404T>A	uc002tla.1	+	15	1812	c.1355T>A	c.(1354-1356)CTG>CAG	p.L452Q	DPP10_uc002tlb.1_Missense_Mutation_p.L402Q|DPP10_uc002tlc.1_Missense_Mutation_p.L448Q|DPP10_uc002tle.2_Missense_Mutation_p.L456Q|DPP10_uc002tlf.1_Missense_Mutation_p.L445Q	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	452	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						GGAAGGCAGCTGTACAGGTAA	0.403													7	62					0	0	0	0	A	116535404	A	A	116535404	3	1	242	1	0	0	0	0	1	0	0	0	4749	1580	55	5	1584	5	DPP10	2	116535404	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	13567093	116535404	126663969	50	44421											
EPB41L5	57669	broad.mit.edu	37	chr2	120844792	120844792	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagaagaataaattaaccttGgtggttgtagaagatgatga	17	11	11	2	0	0	6	0	2	0	4	0	6	0	6	1	2	1	2	1	2	8	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:120844792G>A	uc002tmg.2	+	11	975	c.849G>A	c.(847-849)TTG>TTA	p.L283L	EPB41L5_uc010flk.2_Silent_p.L283L|EPB41L5_uc010fll.2_Silent_p.L283L|EPB41L5_uc002tmh.3_Silent_p.L283L|EPB41L5_uc010flm.2_Silent_p.L87L	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	283	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1						AATTAACCTTGGTGGTTGTAG	0.289													13	43					0	0	0	0	A	120844792	A	A	120844792	2	1	242	1	0	0	0	0	0	0	0	1	5181	1339	47	4		4	EPB41L5	2	120844792	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	4309388	120844792	122354581	51	44422											
GLI2	2736	broad.mit.edu	37	chr2	121747427	121747427	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attcagccctggctggagtgCcaccacctcacccagtccag	8	7	9	17	0	2	0	2	0	0	0	3	1	3	1	6	2	2	1	6	2	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:121747427C>G	uc010flp.2	+	13	3967	c.3937C>G	c.(3937-3939)CCA>GCA	p.P1313A	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Missense_Mutation_p.P985A|GLI2_uc002tmu.3_Missense_Mutation_p.P968A	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1313					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GGCTGGAGTGCCACCACCTCA	0.647													3	32					0	0	0	0	G	121747427	G	G	121747427	3	3	242	1	0	0	0	0	1	0	0	0	6475	739	26	4	3987	4	GLI2	2	121747427	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	902635	121747427	121451946	52	44423											
SAP130	79595	broad.mit.edu	37	chr2	128775403	128775403	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccttaccacaacaggctcttGcttctcctcccgggactgga	7	10	8	16	1	2	0	0	0	2	0	4	2	3	2	4	3	3	2	4	3	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:128775403G>C	uc002tpp.2	-	3	409	c.277C>G	c.(277-279)CAA>GAA	p.Q93E	SAP130_uc002tpo.2_5'Flank|SAP130_uc010fmd.2_Missense_Mutation_p.Q93E|SAP130_uc002tpq.1_Missense_Mutation_p.Q67E	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	93					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		ACAGGCTCTTGCTTCTCCTCC	0.547													21	118					0	0	0	0	C	128775403	C	C	128775403	3	2	242	1	0	0	0	0	1	0	0	0	13896	1328	46	4	3050	4	SAP130	2	128775403	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	7027976	128775403	114423970	53	44424											
YSK4	80122	broad.mit.edu	37	chr2	135745488	135745488	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaaagtgagtgatttcaatTttgttacattcttctatttc	10	20	5	6	0	4	2	2	2	2	0	5	2	4	2	0	0	1	1	0	0	4	8			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:135745488T>A	uc002tue.1	-	7	985	c.954A>T	c.(952-954)AAA>AAT	p.K318N	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.K205N|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.K46N|YSK4_uc002tui.3_Missense_Mutation_p.K335N	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	318							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TGATTTCAATTTTGTTACATT	0.403													21	47					0	0	0	0	A	135745488	A	A	135745488	3	1	242	1	0	0	0	0	1	0	0	0	17563	1838	64	5	3048	5	YSK4	2	135745488	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	6970085	135745488	107453885	54	44425											
GTDC1	79712	broad.mit.edu	37	chr2	144903281	144903281	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcagccagttcggtcaggtTaagcactgaacttgcaaaga	12	8	12	9	1	1	2	1	1	0	1	2	2	1	2	1	3	4	5	1	3	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:144903281T>A	uc002tvp.2	-	5	484	c.205A>T	c.(205-207)AAC>TAC	p.N69Y	GTDC1_uc002tvo.2_Missense_Mutation_p.N69Y|GTDC1_uc002tvq.2_Missense_Mutation_p.N69Y|GTDC1_uc002tvr.2_Missense_Mutation_p.N69Y|GTDC1_uc010fnn.2_Missense_Mutation_p.N69Y|GTDC1_uc002tvs.2_Missense_Mutation_p.N37Y|GTDC1_uc010fno.2_5'UTR|GTDC1_uc002tvt.1_Missense_Mutation_p.N69Y	NM_001006636	NP_001006637	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	69					biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)		TCGGTCAGGTTAAGCACTGAA	0.438													22	64					0	0	0	0	A	144903281	A	A	144903281	3	1	242	1	0	0	0	0	1	0	0	0	6890	1754	61	5	1203	5	GTDC1	2	144903281	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	9157793	144903281	98296092	55	44426											
TTN	7273	broad.mit.edu	37	chr2	179598434	179598434	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaaactaatctgaacatcagGgattatcaagactgcaacac	18	8	6	9	0	3	2	2	1	1	1	3	3	3	3	0	1	4	1	0	1	7	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:179598434G>A	uc010zfg.1	-	50	12174	c.11950C>T	c.(11950-11952)CCT>TCT	p.P3984S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P645S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4911							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAACATCAGGGATTATCAAG	0.413													39	145					0	0	0	0	A	179598434	A	A	179598434	3	1	242	1	0	0	0	0	1	0	0	0	16803	1232	43	4	89087	4	TTN	2	179598434	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	34695153	179598434	63600939	56	44427											
PGAP1	80055	broad.mit.edu	37	chr2	197711732	197711732	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcattcattctttaccttttCaaagctagccacaatgaaga	13	14	4	10	0	4	2	3	1	1	1	4	2	4	2	2	0	3	1	2	0	5	7			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:197711732C>G	uc002utw.2	-	22	2259	c.2145G>C	c.(2143-2145)TTG>TTC	p.L715F	PGAP1_uc002utx.2_Missense_Mutation_p.L541F|PGAP1_uc002uty.1_3'UTR|PGAP1_uc010fsi.2_5'Flank	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	715	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						TTTACCTTTTCAAAGCTAGCC	0.333													10	22					0	0	0	0	G	197711732	G	G	197711732	3	3	242	1	0	0	0	0	1	0	0	0	11832	825	29	2	647	2	PGAP1	2	197711732	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	18113298	197711732	45487641	57	44428											
ANKRD44	91526	broad.mit.edu	37	chr2	197866545	197866545	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catttttgctccaaaagtacCtctatacagttttcattacc	11	16	3	11	0	2	0	1	0	1	0	3	0	3	0	3	0	4	3	3	0	6	8			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:197866545C>T	uc002uua.1	-	22	2369	c.2292G>A	c.(2290-2292)GAG>GAA	p.E764E	ANKRD44_uc002utz.3_Silent_p.E496E	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	789	ANK 23.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CCAAAAGTACCTCTATACAGT	0.333													14	50					0	0	0	0	T	197866545	T	T	197866545	2	4	242	1	0	0	0	0	0	0	0	1	672	680	24	4		4	ANKRD44	2	197866545	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	154813	197866545	45332828	58	44429											
MARS2	92935	broad.mit.edu	37	chr2	198570156	198570156	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgaacgtccgtcctccgcctGctaggacgcacgggggctag	6	6	14	15	6	0	0	0	0	0	0	3	2	3	1	4	3	2	3	4	3	3	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:198570156G>T	uc002uuq.2	+	1	70	c.27G>T	c.(25-27)CTG>CTT	p.L9L	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	9					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	TCCTCCGCCTGCTAGGACGCA	0.662													8	63					2.74318e-10	7.97833e-10	1	0	T	198570156	T	T	198570156	2	4	242	1	0	0	0	0	0	0	0	1	9370	1306	46	4		4	MARS2	2	198570156	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	703611	198570156	44629217	59	44430											
PARD3B	117583	broad.mit.edu	37	chr2	205989155	205989155	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaagggagcagcaataaaaGatggccgcctacaatcaggg	16	4	12	9	1	1	1	1	0	0	1	1	2	1	2	2	3	3	2	2	3	6	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:205989155G>A	uc002var.1	+	9	1477	c.1270G>A	c.(1270-1272)GAT>AAT	p.D424N	PARD3B_uc010fub.1_Missense_Mutation_p.D424N|PARD3B_uc002vao.1_Missense_Mutation_p.D424N|PARD3B_uc002vap.1_Missense_Mutation_p.D424N|PARD3B_uc002vaq.1_Missense_Mutation_p.D424N	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	424	PDZ 2.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		AGCAATAAAAGATGGCCGCCT	0.373													22	59					0	0	0	0	A	205989155	A	A	205989155	3	1	242	1	0	0	0	0	1	0	0	0	11498	942	33	2	1304	2	PARD3B	2	205989155	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	7418999	205989155	37210218	60	44431											
ATIC	471	broad.mit.edu	37	chr2	216190845	216190845	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctccttggagactagacGccagttagccttgaaggtgg	9	9	12	11	1	0	3	0	1	0	2	1	4	1	3	4	3	1	1	4	3	3	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:216190845G>T	uc002vex.3	+	6	689	c.515G>T	c.(514-516)CGC>CTC	p.R172L	ATIC_uc010zjo.1_Missense_Mutation_p.R113L|ATIC_uc002vey.3_Missense_Mutation_p.R171L	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	172					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	GAGACTAGACGCCAGTTAGCC	0.473			T	ALK	ALCL								12	41					9.31168e-06	2.40048e-05	1	0	T	216190845	T	T	216190845	3	4	242	1	0	0	0	0	1	0	0	0	1107	1087	38	3	537	3	ATIC	2	216190845	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	10201690	216190845	27008528	61	44432											
STK36	27148	broad.mit.edu	37	chr2	219543985	219543985	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattgctggtcatgtcaccaGtgagtcatcagggttcccag	8	12	11	10	0	4	1	4	1	0	0	5	1	5	1	2	2	1	2	2	2	1	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr2:219543985G>T	uc002viu.2	+	7	1044	c.778_splice	c.e7+1	p.I260_splice	STK36_uc002viv.2_Splice_Site_p.I260_splice	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36						cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CATGTCACCAGTGAGTCATCA	0.507													16	84					2.23348e-06	5.83351e-06	1	0	T	219543985	T	T	219543985	5	4	242	1	0	0	0	0	0	0	1	0	15368	1043	36	4	801	4	STK36	2	219543985	Splice_Site	SNP	G	TCGA-CV-7254-01A-11D-2012-08	3353140	219543985	23655388	62	44433											
NUP210	23225	broad.mit.edu	37	chr3	13438951	13438951	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atctggatgtcatggatgagGtccacaatggcatcacagcg	11	9	12	9	1	3	1	2	1	1	0	4	3	4	3	1	4	1	1	1	4	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:13438951G>T	uc003bxv.1	-	3	425	c.342C>A	c.(340-342)GAC>GAA	p.D114E		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	114	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CATGGATGAGGTCCACAATGG	0.622													13	35					2.62699e-14	7.96118e-14	1	0	T	13438951	T	T	13438951	3	4	242	1	0	0	0	0	1	0	0	0	10814	1252	44	4	5473	4	NUP210	3	13438951	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08		13438951	184583479	63	44434											
PLCL2	23228	broad.mit.edu	37	chr3	17052474	17052474	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taggagacaagctctatacaAcatcacccaatgttgaggaa	16	8	8	9	0	2	2	1	1	1	1	2	4	2	3	1	2	3	2	1	2	7	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:17052474A>T	uc011awc.1	+	5	1717	c.1612A>T	c.(1612-1614)ACA>TCA	p.T538S	PLCL2_uc010het.1_3'UTR|PLCL2_uc011awd.1_Missense_Mutation_p.T420S	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	546	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GCTCTATACAACATCACCCAA	0.388													8	26					0	0	0	0	T	17052474	T	T	17052474	3	4	242	1	0	0	0	0	1	0	0	0	12095	43	2	5	1636	5	PLCL2	3	17052474	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	3613523	17052474	180969956	64	44435											
NEK10	152110	broad.mit.edu	37	chr3	27203967	27203967	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actaccatgatctttgagatTtcgaagaatcacagcaggaa	15	10	8	8	1	2	3	1	2	1	2	3	6	2	4	1	1	2	1	1	1	4	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:27203967T>A	uc010hfk.2	-	10	1160	c.931A>T	c.(931-933)AAT>TAT	p.N311Y	NEK10_uc003cds.1_Missense_Mutation_p.N396Y|NEK10_uc010hfj.2_Intron			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	999							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TCTTTGAGATTTCGAAGAATC	0.463													28	54					0	0	0	0	A	27203967	A	A	27203967	3	1	242	1	0	0	0	0	1	0	0	0	10376	1856	64	5		5	NEK10	3	27203967	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	10151493	27203967	170818463	65	44436											
EOMES	8320	broad.mit.edu	37	chr3	27760106	27760106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttgtctctgaagccttttgCaaaggggttatgatcaatct	9	15	10	7	0	3	2	1	2	2	0	4	2	3	2	1	2	2	3	1	2	4	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:27760106C>T	uc003cdx.2	-	5	1351	c.1351G>A	c.(1351-1353)GCA>ACA	p.A451T	EOMES_uc003cdy.3_Missense_Mutation_p.A451T|EOMES_uc010hfn.2_3'UTR|EOMES_uc011axc.1_Missense_Mutation_p.A156T	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	451	T-box.				CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						AAGCCTTTTGCAAAGGGGTTA	0.403													10	37					0	0	0	0	T	27760106	T	T	27760106	3	4	242	1	0	0	0	0	1	0	0	0	5171	710	25	4	717	4	EOMES	3	27760106	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	556139	27760106	170262324	66	44437											
TRANK1	9881	broad.mit.edu	37	chr3	36898414	36898414	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cggatgatttccgtgtagatCcgccctgatttctccattgc	6	14	9	12	3	1	3	0	2	1	1	4	4	3	4	4	1	1	1	4	1	1	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:36898414C>A	uc003cgj.2	-	3	1319	c.1017G>T	c.(1015-1017)CGG>CGT	p.R339R		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	889					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CCGTGTAGATCCGCCCTGATT	0.522													11	7					0.000673444	0.00162035	1	0	A	36898414	A	A	36898414	2	1	242	1	0	0	0	0	0	0	0	1	16521	842	30	2		2	TRANK1	3	36898414	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	9138308	36898414	161124016	67	44438											
SLC22A14	9389	broad.mit.edu	37	chr3	38347844	38347844	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atcctggcagtgggcccccaCctgtccaaagctgagcagct	8	7	11	15	0	0	1	0	1	0	0	2	1	2	1	5	2	3	4	5	2	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:38347844C>G	uc010hhc.1	+	2	369	c.327C>G	c.(325-327)CAC>CAG	p.H109Q	SLC22A14_uc003cia.2_Missense_Mutation_p.H109Q|SLC22A14_uc003cib.2_Missense_Mutation_p.H109Q|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	109	Extracellular (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		TGGGCCCCCACCTGTCCAAAG	0.532													35	53					0	0	0	0	G	38347844	G	G	38347844	3	3	242	1	0	0	0	0	1	0	0	0	14510	506	18	4	329	4	SLC22A14	3	38347844	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	1449430	38347844	159674586	68	44439											
MYRIP	25924	broad.mit.edu	37	chr3	40231705	40231705	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgggcaccaggccagactGtcctggttgcagaggaaggc	8	7	16	10	0	0	2	0	0	0	2	1	3	1	3	3	5	1	4	3	5	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:40231705G>A	uc003cka.2	+	10	1551	c.1416G>A	c.(1414-1416)CTG>CTA	p.L472L	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.L472L|MYRIP_uc010hhw.2_Silent_p.L383L|MYRIP_uc011ayz.1_Silent_p.L285L|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	472	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		AGGCCAGACTGTCCTGGTTGC	0.627													37	41					0	0	0	0	A	40231705	A	A	40231705	2	1	242	1	0	0	0	0	0	0	0	1	10153	1364	48	4		4	MYRIP	3	40231705	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1883861	40231705	157790725	69	44440											
ABHD5	51099	broad.mit.edu	37	chr3	43743731	43743731	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttgcacatacaaaaaagAacctgttcgtatatctaatg	15	11	6	9	1	1	1	0	0	1	1	2	1	1	1	2	0	3	3	2	0	8	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:43743731A>C	uc003cmx.2	+	3	268	c.158A>C	c.(157-159)GAA>GCA	p.E53A		NM_016006	NP_057090	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	53					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			ovary(1)	1		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		TACAAAAAAGAACCTGTTCGT	0.338													20	24					0	0	0	0	C	43743731	C	C	43743731	3	2	242	1	0	0	0	0	1	0	0	0	85	246	9	5	168	5	ABHD5	3	43743731	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	3512026	43743731	154278699	70	44441											
ZNF502	91392	broad.mit.edu	37	chr3	44762721	44762721	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtaatatacaaaccaatGatatttcagaccaaagtaaa	21	9	4	7	0	1	2	1	1	0	1	1	2	1	2	2	0	2	2	2	0	10	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:44762721G>T	uc011baa.1	+	4	667	c.412G>T	c.(412-414)GAT>TAT	p.D138Y	ZNF502_uc003cns.2_Missense_Mutation_p.D138Y|ZNF502_uc011bab.1_Missense_Mutation_p.D138Y|ZNF502_uc003cnt.2_Missense_Mutation_p.D138Y	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		ACAAACCAATGATATTTCAGA	0.388													7	41					1.12685e-05	2.88619e-05	1	0	T	44762721	T	T	44762721	3	4	242	1	0	0	0	0	1	0	0	0	18017	1290	45	2	418	2	ZNF502	3	44762721	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1018990	44762721	153259709	71	44442											
SEMA3F	6405	broad.mit.edu	37	chr3	50225414	50225414	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagccagaagtgggcctcAtccaccagtactgccagggt	9	6	11	15	0	1	1	1	0	0	1	2	1	2	1	6	2	3	1	6	2	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:50225414A>T	uc003cyj.2	+	19	2422	c.2224A>T	c.(2224-2226)ATC>TTC	p.I742F	SEMA3F_uc003cyk.2_Missense_Mutation_p.I711F	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	742					axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		AGTGGGCCTCATCCACCAGTA	0.687													4	8					0	0	0	0	T	50225414	T	T	50225414	3	4	242	1	0	0	0	0	1	0	0	0	14094	217	8	5	2294	5	SEMA3F	3	50225414	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	5462693	50225414	147797016	72	44443											
BOC	91653	broad.mit.edu	37	chr3	112999437	112999437	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtaacaacaacaccccaatCcatggcttttatatctatta	15	12	3	11	0	1	0	0	0	1	0	2	0	2	0	3	1	3	2	3	1	8	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:112999437C>A	uc003dzx.2	+	14	2856	c.2235C>A	c.(2233-2235)ATC>ATA	p.I745I	BOC_uc003dzy.2_Silent_p.I745I|BOC_uc003dzz.2_Silent_p.I746I|BOC_uc003eab.2_Silent_p.I446I|BOC_uc003eac.2_Silent_p.I60I	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	745	Fibronectin type-III 3.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			ACACCCCAATCCATGGCTTTT	0.413													10	41					0.000442599	0.00107799	1	0	A	112999437	A	A	112999437	2	1	242	1	0	0	0	0	0	0	0	1	1484	845	30	2		2	BOC	3	112999437	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	62774023	112999437	85022993	73	44444											
C3orf30	152405	broad.mit.edu	37	chr3	118870107	118870107	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tagtctatgaaaagccagagGaccccctgaattttatgctg	12	11	9	9	0	1	3	0	2	1	1	1	4	1	4	3	1	2	1	3	1	6	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:118870107G>A	uc003ecb.1	+	3	1619	c.1579G>A	c.(1579-1581)GAC>AAC	p.D527N	C3orf30_uc011biw.1_Missense_Mutation_p.D526N	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	527										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		AAAGCCAGAGGACCCCCTGAA	0.299													84	156					0	0	0	0	A	118870107	A	A	118870107	3	1	242	1	0	0	0	0	1	0	0	0	2230	1174	41	2	1589	2	C3orf30	3	118870107	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	5870670	118870107	79152323	74	44445											
PLXNA1	5361	broad.mit.edu	37	chr3	126747090	126747090	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtgaaggggctggactgtGacacggtcacccaggccaag	9	5	16	11	2	1	2	1	2	0	0	1	3	1	3	2	6	0	1	2	6	2	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:126747090G>T	uc003ejg.2	+	24	4511	c.4507G>T	c.(4507-4509)GAC>TAC	p.D1503Y	PLXNA1_uc003ejh.2_Missense_Mutation_p.D171Y	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1526	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		GCTGGACTGTGACACGGTCAC	0.657													12	31					1.08611e-07	2.96347e-07	1	0	T	126747090	T	T	126747090	3	4	242	1	0	0	0	0	1	0	0	0	12174	1290	45	2	4670	2	PLXNA1	3	126747090	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	7876983	126747090	71275340	75	44446											
A4GNT	51146	broad.mit.edu	37	chr3	137843691	137843691	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatgcatccgagctgatgtgGagccagtttctctctgcgct	6	12	12	11	2	2	1	0	1	2	0	4	4	3	2	2	1	4	4	2	1	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:137843691G>T	uc003ers.2	-	3	640	c.438C>A	c.(436-438)CTC>CTA	p.L146L		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	146	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						AGCTGATGTGGAGCCAGTTTC	0.587													6	68					0.00198382	0.00473018	1	0	T	137843691	T	T	137843691	2	4	242	1	0	0	0	0	0	0	0	1	7	1161	41	2		2	A4GNT	3	137843691	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	11096601	137843691	60178739	76	44447											
GPR149	344758	broad.mit.edu	37	chr3	154138924	154138924	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacagtcttctttctggcccTtcagaaaaggtagtttcttc	8	15	8	10	0	5	1	1	0	4	1	6	2	5	1	1	2	0	2	1	2	3	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr3:154138924T>A	uc003faa.2	-	3	1627	c.1527A>T	c.(1525-1527)GAA>GAT	p.E509D		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	509	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTTCTGGCCCTTCAGAAAAGG	0.413													105	98					0	0	0	0	A	154138924	A	A	154138924	3	1	242	1	0	0	0	0	1	0	0	0	6692	1606	56	5	676	5	GPR149	3	154138924	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	16295233	154138924	43883506	77	44448											
KDR	3791	broad.mit.edu	37	chr4	55964304	55964304	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatagcaattgaaaatgcacCtagcttcagccggtctctgg	12	10	9	10	1	2	1	1	1	1	0	3	1	2	1	2	2	4	3	2	2	6	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:55964304C>A	uc003has.2	-	17	2811	c.2509G>T	c.(2509-2511)GGT>TGT	p.G837C	KDR_uc003hat.1_Missense_Mutation_p.G837C	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	837	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GAAAATGCACCTAGCTTCAGC	0.423			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			7	66					5.4927e-09	1.53564e-08	1	0	A	55964304	A	A	55964304	3	1	242	1	0	0	0	0	1	0	0	0	8178	695	24	4	1617	4	KDR	4	55964304	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08		55964304	135189972	78	44449											
KDR	3791	broad.mit.edu	37	chr4	55970955	55970955	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgctattagagaacatggtGgcattcaatttccaaagagt	13	12	10	6	0	1	2	1	0	0	2	2	3	2	2	1	2	2	2	1	2	5	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:55970955G>T	uc003has.2	-	13	2144	c.1842C>A	c.(1840-1842)GCC>GCA	p.A614A	KDR_uc003hat.1_Silent_p.A614A|KDR_uc011bzx.1_Silent_p.A614A	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	614	Ig-like C2-type 6.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGAACATGGTGGCATTCAATT	0.463			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			17	91					4.7546e-09	1.34827e-08	1	0	T	55970955	T	T	55970955	2	4	242	1	0	0	0	0	0	0	0	1	8178	1335	47	4		4	KDR	4	55970955	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	6651	55970955	135183321	79	44450											
REST	5978	broad.mit.edu	37	chr4	57797980	57797980	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaagaacgtgaagcagtgTccaaaactgcactggcatca	15	7	10	9	1	1	3	1	1	0	2	2	3	2	3	1	1	4	3	1	1	6	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:57797980T>C	uc003hch.2	+	4	3303	c.2956T>C	c.(2956-2958)TCC>CCC	p.S986P	REST_uc003hci.2_Missense_Mutation_p.S986P|REST_uc010ihf.2_Missense_Mutation_p.S660P	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	986					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding	p.S986F(1)		skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					TGAAGCAGTGTCCAAAACTGC	0.453													3	66					0	0	0	0	C	57797980	C	C	57797980	3	2	242	1	0	0	0	0	1	0	0	0	13299	1667	58	5	2966	5	REST	4	57797980	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	1827025	57797980	133356296	80	44451											
PROL1	58503	broad.mit.edu	37	chr4	71275379	71275379	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacatttcccactaagacctTactatgtaggacctattagg	12	13	6	10	0	0	1	0	0	0	1	1	2	1	2	3	2	2	1	3	2	7	8			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:71275379T>C	uc003hfi.2	+	3	508	c.334T>C	c.(334-336)TAC>CAC	p.Y112H		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	112	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				ACTAAGACCTTACTATGTAGG	0.393													48	135					0	0	0	0	C	71275379	C	C	71275379	3	2	242	1	0	0	0	0	1	0	0	0	12616	1754	61	5	340	5	PROL1	4	71275379	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	13477399	71275379	119878897	81	44452											
FRAS1	80144	broad.mit.edu	37	chr4	79207678	79207678	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggacggcttctaccaagatCgccattcctgtgcaggtaat	9	10	11	11	2	1	1	0	0	1	1	3	2	2	2	3	3	2	3	3	3	3	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:79207678C>A	uc003hlb.2	+	14	1959	c.1519C>A	c.(1519-1521)CGC>AGC	p.R507S	FRAS1_uc003hkw.2_Missense_Mutation_p.R507S|FRAS1_uc003hky.1_Missense_Mutation_p.R211S|FRAS1_uc003hkz.2_Missense_Mutation_p.R211S|FRAS1_uc003hla.1_Missense_Mutation_p.R18S	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	507	FU 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CTACCAAGATCGCCATTCCTG	0.622													10	57					0.00010058	0.000248786	1	0	A	79207678	A	A	79207678	3	1	242	1	0	0	0	0	1	0	0	0	6076	884	31	3	1573	3	FRAS1	4	79207678	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	7932299	79207678	111946598	82	44453											
PRKG2	5593	broad.mit.edu	37	chr4	82061705	82061705	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttcacaatgaatggagagCacagctcctctaggatcctc	12	9	8	12	0	2	2	1	1	1	1	5	4	4	3	2	2	2	2	2	2	3	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:82061705C>G	uc003hmh.2	-	11	1540	c.1526G>C	c.(1525-1527)TGC>TCC	p.C509S	PRKG2_uc011ccf.1_Missense_Mutation_p.C89S|PRKG2_uc011ccg.1_Missense_Mutation_p.C89S|PRKG2_uc011cch.1_Missense_Mutation_p.C480S	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	509	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						GAATGGAGAGCACAGCTCCTC	0.363													11	77					0	0	0	0	G	82061705	G	G	82061705	3	3	242	1	0	0	0	0	1	0	0	0	12585	710	25	4	794	4	PRKG2	4	82061705	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	2854027	82061705	109092571	83	44454											
HERC5	51191	broad.mit.edu	37	chr4	89407343	89407343	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caccgtctcaatttttttgtAgaagtatgcagaaggtactt	11	15	8	7	1	1	2	1	0	1	2	2	2	1	2	1	1	2	4	1	1	6	7			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:89407343A>G	uc003hrt.2	+	14	1968	c.1815A>G	c.(1813-1815)GTA>GTG	p.V605V	HERC5_uc011cdm.1_Silent_p.V243V	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	605					innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		ATTTTTTTGTAGAAGTATGCA	0.358													18	43					0	0	0	0	G	89407343	G	G	89407343	2	3	242	1	0	0	0	0	0	0	0	1	7100	407	15	5		5	HERC5	4	89407343	Silent	SNP	A	TCGA-CV-7254-01A-11D-2012-08	7345638	89407343	101746933	84	44455											
PITX2	5308	broad.mit.edu	37	chr4	111539443	111539443	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacggaggagtcggcggcgcGtaaggacaggcaggcgtcgg	8	4	20	9	7	0	0	0	0	0	0	2	3	0	3	0	8	1	2	0	8	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:111539443G>C	uc003iad.2	-	5	1374	c.792C>G	c.(790-792)TAC>TAG	p.Y264*	PITX2_uc003iac.2_Nonsense_Mutation_p.Y271*|PITX2_uc003iae.2_Nonsense_Mutation_p.Y218*|PITX2_uc010iml.2_Nonsense_Mutation_p.Y135*|PITX2_uc003iaf.2_Nonsense_Mutation_p.Y264*	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	264					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		TCGGCGGCGCGTAAGGACAGG	0.592													8	55					0	0	0	0	C	111539443	C	C	111539443	4	2	242	1	0	0	0	0	0	1	0	0	12010	1140	40	3	165	3	PITX2	4	111539443	Nonsense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	22132100	111539443	79614833	85	44456											
NDST3	9348	broad.mit.edu	37	chr4	119148127	119148127	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaattcttggtaataggaccCcagaaaactggtgagaactt	15	10	9	7	0	1	2	0	1	1	2	1	4	1	3	2	3	2	1	2	3	6	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:119148127C>A	uc003ibx.2	+	8	2212	c.1809C>A	c.(1807-1809)CCC>CCA	p.P603P	NDST3_uc011cgf.1_Silent_p.P522P	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	603	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						TAATAGGACCCCAGAAAACTG	0.368													12	70					0.000978159	0.0023464	1	0	A	119148127	A	A	119148127	2	1	242	1	0	0	0	0	0	0	0	1	10311	610	22	4		4	NDST3	4	119148127	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	7608684	119148127	72006149	86	44457											
PDE5A	8654	broad.mit.edu	37	chr4	120446754	120446754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttgaggtcagtaaacatccGaattgtacacagtgctgttt	11	13	10	7	1	1	1	1	1	0	0	2	2	2	1	1	1	3	5	1	1	4	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:120446754G>A	uc003idh.2	-	12	1884	c.1729C>T	c.(1729-1731)CGG>TGG	p.R577W	uc003ide.3_Intron|PDE5A_uc003idf.2_Missense_Mutation_p.R535W|PDE5A_uc003idg.2_Missense_Mutation_p.R525W|uc003idi.3_Intron	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	577					platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	GTAAACATCCGAATTGTACAC	0.448													25	42					0	0	0	0	A	120446754	A	A	120446754	3	1	242	1	0	0	0	0	1	0	0	0	11698	1057	37	1	938	1	PDE5A	4	120446754	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1298627	120446754	70707522	87	44458											
NPY2R	4887	broad.mit.edu	37	chr4	156136121	156136121	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcggccttccgctgtgagCagcggttggatgccattcac	5	11	12	13	3	2	1	1	1	1	0	4	2	3	2	3	3	3	3	3	3	0	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:156136121C>G	uc003ioq.2	+	2	1525	c.1030C>G	c.(1030-1032)CAG>GAG	p.Q344E	NPY2R_uc003ior.2_Missense_Mutation_p.Q344E	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	344	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				CCGCTGTGAGCAGCGGTTGGA	0.512													14	71					0	0	0	0	G	156136121	G	G	156136121	3	3	242	1	0	0	0	0	1	0	0	0	10663	711	25	4	1032	4	NPY2R	4	156136121	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	35689367	156136121	35018155	88	44459											
GLRB	2743	broad.mit.edu	37	chr4	158091726	158091726	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acccattgaagttaacaacgGacttgggaaatctcaggcta	14	9	9	9	1	1	1	1	1	1	0	2	3	1	3	1	3	2	2	1	3	5	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:158091726G>C	uc003ipj.2	+	10	1542	c.1340G>C	c.(1339-1341)GGA>GCA	p.G447A		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	447	Cytoplasmic (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GTTAACAACGGACTTGGGAAA	0.413													3	47					0	0	0	0	C	158091726	C	C	158091726	3	2	242	1	0	0	0	0	1	0	0	0	6495	1174	41	2	1374	2	GLRB	4	158091726	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1955605	158091726	33062550	89	44460											
FAT1	2195	broad.mit.edu	37	chr4	187522436	187522436	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacatacctccaagatgctaTagtcagttcctcgagcatac	13	10	6	12	1	1	1	1	0	0	1	4	2	3	1	3	0	5	3	3	0	6	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:187522436T>C	uc003izf.2	-	21	11815	c.11627A>G	c.(11626-11628)TAT>TGT	p.Y3876C		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3876	Extracellular (Potential).|Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CAAGATGCTATAGTCAGTTCC	0.388										HNSCC(5;0.00058)			3	27					0	0	0	0	C	187522436	C	C	187522436	3	2	242	1	0	0	0	0	1	0	0	0	5721	1406	49	5	2167	5	FAT1	4	187522436	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	29430710	187522436	3631840	90	44461											
TRIML1	339976	broad.mit.edu	37	chr4	189068327	189068327	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcagcacgtcagagagcCtgtgtgtaaggttggtgtct	8	11	15	7	1	3	1	2	0	1	1	3	2	3	1	1	3	2	3	1	3	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr4:189068327C>A	uc003izm.1	+	6	1323	c.1208C>A	c.(1207-1209)CCT>CAT	p.P403H	TRIML1_uc003izn.1_Missense_Mutation_p.P127H	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	403	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GTCAGAGAGCCTGTGTGTAAG	0.488													21	68					4.35082e-09	1.24264e-08	1	0	A	189068327	A	A	189068327	3	1	242	1	0	0	0	0	1	0	0	0	16617	681	24	4	1230	4	TRIML1	4	189068327	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	1545891	189068327	2085949	91	44462											
AHRR	57491	broad.mit.edu	37	chr5	422969	422969	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcagcccccgcccttggaGacaggtgggtgtctggggtc	4	7	18	12	1	1	1	0	0	1	1	2	2	1	1	3	6	1	1	3	6	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:422969G>A	uc003jav.2	+	6	623	c.579G>A	c.(577-579)GAG>GAA	p.E193E	AHRR_uc003jaw.2_Silent_p.E189E|AHRR_uc010isy.2_Silent_p.E39E|AHRR_uc010isz.2_Silent_p.E189E|AHRR_uc003jax.2_Intron|AHRR_uc003jay.2_Silent_p.E49E	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			CGCCCTTGGAGACAGGTGGGT	0.602													8	32					0	0	0	0	A	422969	A	A	422969	2	1	242	1	0	0	0	0	0	0	0	1	417	933	33	2		2	AHRR	5	422969	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08		422969	180492291	92	44463											
IRX2	153572	broad.mit.edu	37	chr5	2749089	2749089	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgcacagggggtccccggCgcggcacggaagcttctccc	5	6	14	16	5	1	0	0	0	1	0	4	1	2	1	3	5	1	3	3	5	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:2749089C>T	uc003jda.2	-	3	975	c.733G>A	c.(733-735)GCC>ACC	p.A245T	IRX2_uc003jdb.2_Missense_Mutation_p.A245T	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		GGGTCCCCGGCGCGGCACGGA	0.701													7	36					0	0	0	0	T	2749089	T	T	2749089	3	4	242	1	0	0	0	0	1	0	0	0	7883	768	27	1	690	1	IRX2	5	2749089	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	2326120	2749089	178166171	93	44464											
CTNND2	1501	broad.mit.edu	37	chr5	11397213	11397213	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgtgaaggggtggtttccCccagggccagggtctggttg	4	10	18	9	0	1	1	0	1	1	0	2	1	2	1	3	6	0	3	3	6	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:11397213C>G	uc003jfa.1	-	6	687	c.542G>C	c.(541-543)GGG>GCG	p.G181A	CTNND2_uc010itt.2_Missense_Mutation_p.G90A|CTNND2_uc011cmy.1_Intron|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_Intron	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	181					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GGTGGTTTCCCCCAGGGCCAG	0.607													24	65					0	0	0	0	G	11397213	G	G	11397213	3	3	242	1	0	0	0	0	1	0	0	0	4037	623	22	4	3203	4	CTNND2	5	11397213	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	8648124	11397213	169518047	94	44465											
DNAH5	1767	broad.mit.edu	37	chr5	13714614	13714614	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccctccaccagaggtgtccTtgggttggatgcctaggatg	6	10	13	12	0	0	1	0	0	0	1	2	3	2	3	6	4	1	1	6	4	1	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:13714614T>A	uc003jfd.2	-	75	13067	c.13025A>T	c.(13024-13026)AAG>ATG	p.K4342M	DNAH5_uc003jfc.2_Missense_Mutation_p.K510M	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4342					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGAGGTGTCCTTGGGTTGGAT	0.607									Kartagener_syndrome				15	76					0	0	0	0	A	13714614	A	A	13714614	3	1	242	1	0	0	0	0	1	0	0	0	4626	1609	56	5	869	5	DNAH5	5	13714614	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	2317401	13714614	167200646	95	44466											
PRDM9	56979	broad.mit.edu	37	chr5	23524491	23524491	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagcagaacctggtggccttCcagtaccacaggcagatctt	10	8	11	12	0	1	2	0	0	1	2	2	3	2	2	4	3	3	3	4	3	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:23524491C>G	uc003jgo.2	+	10	1181	c.999C>G	c.(997-999)TTC>TTG	p.F333L		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	333	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TGGTGGCCTTCCAGTACCACA	0.537										HNSCC(3;0.000094)			13	57					0	0	0	0	G	23524491	G	G	23524491	3	3	242	1	0	0	0	0	1	0	0	0	12525	854	30	2	1033	2	PRDM9	5	23524491	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	9809877	23524491	157390769	96	44467											
HMGCS1	3157	broad.mit.edu	37	chr5	43295957	43295957	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatttctgaaccagtttacAatatggtgagtgaaagatca	15	12	9	5	0	2	5	1	3	1	2	2	5	2	5	1	1	2	1	1	1	5	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:43295957A>T	uc003jnr.3	-	6	1009	c.802T>A	c.(802-804)TGT>AGT	p.C268S	HMGCS1_uc003jnp.3_5'Flank|HMGCS1_uc003jnq.3_Missense_Mutation_p.C268S	NM_001098272	NP_001091742	Q01581	HMCS1_HUMAN	hydroxymethylglutaryl-CoA synthase 1	268					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity				0						ACCAGTTTACAATATGGTGAG	0.353													11	55					0	0	0	0	T	43295957	T	T	43295957	3	4	242	1	0	0	0	0	1	0	0	0	7271	130	5	5	784	5	HMGCS1	5	43295957	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	19771466	43295957	137619303	97	44468											
MCCC2	64087	broad.mit.edu	37	chr5	70952610	70952610	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatccagcagacaccagaCtggtcttgggtctcagtttt	8	13	10	10	0	2	3	1	1	2	2	4	3	3	3	2	2	1	2	2	2	0	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:70952610C>T	uc003kbs.3	+	17	1753	c.1615C>T	c.(1615-1617)CTG>TTG	p.L539L	MCCC2_uc003kbt.3_RNA	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	539	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	AGACACCAGACTGGTCTTGGG	0.413													37	74					0	0	0	0	T	70952610	T	T	70952610	2	4	242	1	0	0	0	0	0	0	0	1	9428	564	20	4		4	MCCC2	5	70952610	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	27656653	70952610	109962650	98	44469											
IQGAP2	10788	broad.mit.edu	37	chr5	75989261	75989261	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttagagacaccagcaactgcGcaacaggtaatttgacttta	14	10	8	9	1	0	2	0	1	0	1	0	3	0	2	1	1	4	3	1	1	5	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:75989261G>T	uc003kek.2	+	31	4209	c.3987G>T	c.(3985-3987)GCG>GCT	p.A1329A	IQGAP2_uc011csv.1_Silent_p.A825A|IQGAP2_uc003kel.2_Silent_p.A825A|IQGAP2_uc010izw.1_Silent_p.A30A	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1329					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CAGCAACTGCGCAACAGGTAA	0.363													7	19					5.4927e-09	1.53564e-08	1	0	T	75989261	T	T	75989261	2	4	242	1	0	0	0	0	0	0	0	1	7854	1074	38	3		3	IQGAP2	5	75989261	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	5036651	75989261	104925999	99	44470											
VCAN	1462	broad.mit.edu	37	chr5	82836553	82836553	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatcggataaaaatactatCatagatattgatcatactaa	19	12	4	6	1	2	2	2	1	0	1	3	3	2	3	0	1	2	0	0	1	9	8			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:82836553C>G	uc003kii.3	+	8	8087	c.7731C>G	c.(7729-7731)ATC>ATG	p.I2577M	VCAN_uc003kij.3_Missense_Mutation_p.I1590M|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.I1241M	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2577	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAAATACTATCATAGATATTG	0.358													17	28					0	0	0	0	G	82836553	G	G	82836553	3	3	242	1	0	0	0	0	1	0	0	0	17206	816	29	2	7757	2	VCAN	5	82836553	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	6847292	82836553	98078707	100	44471											
PCDHB8	56128	broad.mit.edu	37	chr5	140559200	140559200	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acgaggccctgcaggcgttcGagttccgggtgggcgcttca	5	8	16	12	5	1	0	1	0	0	0	3	2	2	0	2	4	1	4	2	4	0	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:140559200G>C	uc011dai.1	+	1	1771	c.1585G>C	c.(1585-1587)GAG>CAG	p.E529Q	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	529	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGGCGTTCGAGTTCCGGGT	0.677													54	255					0	0	0	0	C	140559200	C	C	140559200	3	2	242	1	0	0	0	0	1	0	0	0	11602	1059	37	3	1587	3	PCDHB8	5	140559200	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	57722647	140559200	40356060	101	44472											
PCDHB16	57717	broad.mit.edu	37	chr5	140563937	140563937	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gactcgggccagaatgcctgGctgtcgtaccagctgctcaa	8	8	12	13	2	1	1	1	0	0	1	3	2	1	1	3	2	4	4	3	2	3	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:140563937G>C	uc003liv.2	+	1	2958	c.1803G>C	c.(1801-1803)TGG>TGC	p.W601C	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	601	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAATGCCTGGCTGTCGTACC	0.721													52	40					0	0	0	0	C	140563937	C	C	140563937	3	2	242	1	0	0	0	0	1	0	0	0	11595	1212	42	4	1805	4	PCDHB16	5	140563937	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	4737	140563937	40351323	102	44473											
PCDHB13	56123	broad.mit.edu	37	chr5	140594219	140594219	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgagaactatataatcagccCcaactcctattttcgggtcc	11	12	6	12	1	1	1	1	1	0	1	4	2	3	1	4	1	3	0	4	1	6	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:140594219C>G	uc003lja.1	+	1	711	c.524C>G	c.(523-525)CCC>CGC	p.P175R		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	175	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATAATCAGCCCCAACTCCTAT	0.493													25	43					0	0	0	0	G	140594219	G	G	140594219	3	3	242	1	0	0	0	0	1	0	0	0	11592	623	22	4	526	4	PCDHB13	5	140594219	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	30282	140594219	40321041	103	44474											
MGAT1	4245	broad.mit.edu	37	chr5	180219088	180219088	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccgcccctgccgctgctccGgccgccgcatccagtcgtcc	2	6	10	23	6	0	0	0	0	0	0	4	0	3	0	9	1	2	3	9	1	0	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr5:180219088G>T	uc003mmg.3	-	2	1379	c.884C>A	c.(883-885)CCG>CAG	p.P295Q	MGAT1_uc010jlf.2_Missense_Mutation_p.P295Q|MGAT1_uc010jlg.2_Missense_Mutation_p.P295Q|MGAT1_uc003mmh.3_Missense_Mutation_p.P295Q|MGAT1_uc010jlh.2_Missense_Mutation_p.P295Q|MGAT1_uc003mmi.3_Missense_Mutation_p.P295Q	NM_002406	NP_002397	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein	295	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(1)	1	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCGCTGCTCCGGCCGCCGCAT	0.647													17	12					3.8784e-16	1.20763e-15	1	0	T	180219088	T	T	180219088	3	4	242	1	0	0	0	0	1	0	0	0	9595	1116	39	3	457	3	MGAT1	5	180219088	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	39624869	180219088	696172	104	44475											
MRS2	57380	broad.mit.edu	37	chr6	24423169	24423169	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgttctcttttaggaccAtagaattttttggctgatta	8	19	8	6	0	1	2	0	1	1	1	2	3	1	3	1	2	0	2	1	2	4	8			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr6:24423169A>G	uc003neb.2	+	10	1234	c.1112A>G	c.(1111-1113)CAT>CGT	p.H371R	MRS2_uc003nea.2_Missense_Mutation_p.H371R|MRS2_uc011djl.1_Missense_Mutation_p.H374R|MRS2_uc011djm.1_RNA|MRS2_uc011djn.1_Missense_Mutation_p.H321R|MRS2_uc003nec.2_Missense_Mutation_p.H248R	NM_020662	NP_065713	Q9HD23	MRS2_HUMAN	MRS2-like, magnesium homeostasis factor	371	Mitochondrial intermembrane (Potential).				ion transport	integral to membrane|mitochondrial inner membrane					0						TTTTAGGACCATAGAATTTTT	0.438													40	58					0	0	0	0	G	24423169	G	G	24423169	3	3	242	1	0	0	0	0	1	0	0	0	9904	217	8	5	1150	5	MRS2	6	24423169	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08		24423169	146691898	105	44476											
C6orf25	80739	broad.mit.edu	37	chr6	31692374	31692374	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcccttacaggcgcctgcccCcgcaaccgattcgaccactc	7	7	7	20	4	0	0	0	0	0	0	3	2	1	0	6	1	3	1	6	1	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr6:31692374C>A	uc011doc.1	+	4	511	c.511C>A	c.(511-513)CCG>ACG	p.P171T	LY6G6C_uc003nwh.2_5'Flank|LY6G6C_uc010jtd.2_5'Flank|C6orf25_uc003nwk.2_Missense_Mutation_p.P171T|C6orf25_uc011dod.1_Intron|C6orf25_uc011doe.1_Silent_p.P140P|C6orf25_uc003nwo.2_Intron|C6orf25_uc003nwn.2_Missense_Mutation_p.P171T	NM_138272	NP_612116	O95866	G6B_HUMAN	G6B protein isoform G6b-B precursor	171	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity				0						GCGCCTGCCCCCGCAACCGAT	0.542													14	86					2.23348e-06	5.83351e-06	1	0	A	31692374	A	A	31692374	3	1	242	1	0	0	0	0	1	0	0	0	2370	623	22	4	525	4	C6orf25	6	31692374	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	7269205	31692374	139422693	106	44477											
EHMT2	10919	broad.mit.edu	37	chr6	31864040	31864040	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctctcccatcccactcacCtgtccatttcctggtttgga	6	14	5	16	0	2	0	1	0	1	0	7	1	6	1	5	2	0	1	5	2	0	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr6:31864040C>T	uc003nxz.1	-	4	592	c.582G>A	c.(580-582)CAG>CAA	p.Q194Q	EHMT2_uc003nxy.1_5'UTR|EHMT2_uc011don.1_Silent_p.Q251Q|EHMT2_uc003nya.1_Silent_p.Q194Q|EHMT2_uc003nyb.1_Silent_p.Q194Q|C2_uc003nyc.2_5'Flank|C2_uc011doo.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	194					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						TCCCACTCACCTGTCCATTTC	0.493													44	62					0	0	0	0	T	31864040	T	T	31864040	2	4	242	1	0	0	0	0	0	0	0	1	5006	695	24	4		4	EHMT2	6	31864040	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	171666	31864040	139251027	107	44478											
TDRD6	221400	broad.mit.edu	37	chr6	46660541	46660541	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gactgctggagaacaggtagCagacaggagaaattgtatcc	14	7	13	7	0	0	3	0	0	0	3	1	6	1	3	1	3	3	4	1	3	4	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr6:46660541C>A	uc003oyj.2	+	1	4676	c.4676C>A	c.(4675-4677)GCA>GAA	p.A1559E	TDRD6_uc010jze.2_Missense_Mutation_p.A1553E	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1559					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GAACAGGTAGCAGACAGGAGA	0.388													6	47					1.06961e-07	2.92853e-07	1	0	A	46660541	A	A	46660541	3	1	242	1	0	0	0	0	1	0	0	0	15800	710	25	4	4678	4	TDRD6	6	46660541	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	14796501	46660541	124454526	108	44479											
LAMA4	3910	broad.mit.edu	37	chr6	112512959	112512959	+	Frame_Shift_Del	DEL	A	-	-																															gtgacttcatcacaatcttcAaagatcaggttgggatctga																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr6:112512959delA	uc003pvu.2	-	6	906	c.597delT	c.(595-597)TTTfs	p.F199fs	LAMA4_uc003pvv.2_Frame_Shift_Del_p.F199fs|LAMA4_uc003pvt.2_Frame_Shift_Del_p.F199fs	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	199	Laminin EGF-like 3.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CACAATCTTCAAAGATCAGGT	0.483													---	---	---								-	112512959	-	-	112512959	7	5	242	1	0	1	0	1	0	0	0	0	8648	127	5	0	5010	0	LAMA4	6	112512959	Frame_Shift_Del	DEL	A	TCGA-CV-7254-01A-11D-2012-08	65852418	112512959	58602108	109	44480											
RFX6	222546	broad.mit.edu	37	chr6	117240431	117240431	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atttgtatcttctctgaaacGacaaacatctttcttacatc	12	16	3	10	1	4	1	0	1	4	0	6	2	4	1	0	0	3	1	0	0	4	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr6:117240431G>A	uc003pxm.2	+	11	1217	c.1154G>A	c.(1153-1155)CGA>CAA	p.R385Q		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	385					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TCTCTGAAACGACAAACATCT	0.363													9	43					0	0	0	0	A	117240431	A	A	117240431	3	1	242	1	0	0	0	0	1	0	0	0	13332	1058	37	1	1196	1	RFX6	6	117240431	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	4727472	117240431	53874636	110	44481											
TMEM200A	114801	broad.mit.edu	37	chr6	130761863	130761863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctgaaacaacactgtcaaCaaatgaaactcaggtcattc	16	9	6	10	0	3	2	3	2	0	0	4	2	3	2	0	1	5	1	0	1	5	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr6:130761863C>T	uc003qca.2	+	3	1167	c.296C>T	c.(295-297)ACA>ATA	p.T99I	TMEM200A_uc010kfh.2_Missense_Mutation_p.T99I|TMEM200A_uc010kfi.2_Missense_Mutation_p.T99I|TMEM200A_uc003qcb.2_Missense_Mutation_p.T99I	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	99	Extracellular (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		ACACTGTCAACAAATGAAACT	0.418													27	42					0	0	0	0	T	130761863	T	T	130761863	3	4	242	1	0	0	0	0	1	0	0	0	16189	478	17	4	298	4	TMEM200A	6	130761863	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	13521432	130761863	40353204	111	44482											
C6orf118	168090	broad.mit.edu	37	chr6	165715309	165715309	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctcctgcgccatccaggagGgccccgtccaggagggcctc	5	5	13	18	2	0	0	0	0	0	0	4	2	3	2	8	4	1	0	8	4	0	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr6:165715309G>T	uc003qum.3	-	2	538	c.502C>A	c.(502-504)CCT>ACT	p.P168T	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	168											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CATCCAGGAGGGCCCCGTCCA	0.622													33	42					8.4185e-14	2.54156e-13	1	0	T	165715309	T	T	165715309	3	4	242	1	0	0	0	0	1	0	0	0	2333	1232	43	4	939	4	C6orf118	6	165715309	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	34953446	165715309	5399758	112	44483											
PDE10A	10846	broad.mit.edu	37	chr6	165832125	165832125	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctacttctagctgtacctTatctctttggtcttcttgaa	6	20	5	10	0	5	1	0	1	5	0	6	1	5	1	1	1	3	2	1	1	5	9			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr6:165832125T>C	uc003qun.2	-	12	1207	c.966A>G	c.(964-966)ATA>ATG	p.I322M	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.I252M|PDE10A_uc003quo.2_Missense_Mutation_p.I332M	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	322	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	AGCTGTACCTTATCTCTTTGG	0.413													19	29					0	0	0	0	C	165832125	C	C	165832125	3	2	242	1	0	0	0	0	1	0	0	0	11684	1744	61	5	1421	5	PDE10A	6	165832125	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	116816	165832125	5282942	113	44484											
MLLT4	4301	broad.mit.edu	37	chr6	168344628	168344628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcttctcctagggcggcaGaactcatgacaagaacaagc	12	8	9	12	1	3	3	1	1	2	2	4	3	3	3	1	2	3	1	1	2	5	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr6:168344628G>A	uc003qwd.2	+	25	3365	c.3223G>A	c.(3223-3225)GAA>AAA	p.E1075K	MLLT4_uc003qwb.1_Missense_Mutation_p.E1060K|MLLT4_uc003qwc.1_Missense_Mutation_p.E1076K|MLLT4_uc003qwg.1_Missense_Mutation_p.E385K	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1076	PDZ.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TAGGGCGGCAGAACTCATGAC	0.478			T	MLL	AL								25	38					0	0	0	0	A	168344628	A	A	168344628	3	1	242	1	0	0	0	0	1	0	0	0	9682	943	33	2	3324	2	MLLT4	6	168344628	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	2512503	168344628	2770439	114	44485											
MIOS	54468	broad.mit.edu	37	chr7	7622858	7622858	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctttgtgggtggataaaGaaaggaacggatgtagacgt	13	9	15	4	2	0	2	0	0	0	2	0	5	0	5	0	4	2	2	0	4	5	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:7622858G>A	uc003srf.2	+	6	1811	c.1503G>A	c.(1501-1503)AAG>AAA	p.K501K	MIOS_uc003srg.2_Silent_p.K36K|MIOS_uc010ktq.2_5'Flank	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	501											0						GGTGGATAAAGAAAGGAACGG	0.413													6	84					0	0	0	0	A	7622858	A	A	7622858	2	1	242	1	0	0	0	0	0	0	0	1	9642	933	33	2		2	MIOS	7	7622858	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08		7622858	151515805	115	44486											
TBRG4	9238	broad.mit.edu	37	chr7	45141455	45141455	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatactgcgtggccacctcGaggctgcccttgtcggcgct	4	9	12	16	4	0	0	0	0	0	0	2	1	0	0	4	3	3	2	4	3	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:45141455G>A	uc003tmv.2	-	8	1662	c.1536C>T	c.(1534-1536)CTC>CTT	p.L512L	TBRG4_uc003tmu.2_Silent_p.L337L|TBRG4_uc003tmw.2_Silent_p.L402L|TBRG4_uc003tmx.2_Silent_p.L402L|TBRG4_uc011kcd.1_Silent_p.L523L	NM_004749	NP_004740	Q969Z0	TBRG4_HUMAN	cell cycle progression 2 protein isoform 1	512					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity				0						TGGCCACCTCGAGGCTGCCCT	0.662													15	62					0	0	0	0	A	45141455	A	A	45141455	2	1	242	1	0	0	0	0	0	0	0	1	15715	1045	37	1		1	TBRG4	7	45141455	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	37518597	45141455	113997208	116	44487											
CALN1	83698	broad.mit.edu	37	chr7	71571178	71571178	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatgatggccagctccacctCgcttggcatgtaccccaaag	9	8	10	14	1	0	1	0	1	0	0	2	2	1	1	5	2	2	4	5	2	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:71571178C>T	uc003twa.3	-	3	747	c.220G>A	c.(220-222)GAG>AAG	p.E74K	CALN1_uc003twb.3_Missense_Mutation_p.E116K|CALN1_uc003twc.3_Missense_Mutation_p.E74K	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	74	EF-hand 2.|Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				AGCTCCACCTCGCTTGGCATG	0.597													4	44					0	0	0	0	T	71571178	T	T	71571178	3	4	242	1	0	0	0	0	1	0	0	0	2603	893	31	1	455	1	CALN1	7	71571178	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	26429723	71571178	87567485	117	44488											
PCLO	27445	broad.mit.edu	37	chr7	82580057	82580057	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctgagctaacgtctcctGcctcatcatgaactgggctt	7	13	9	12	1	3	2	2	2	1	0	4	2	3	2	2	1	5	3	2	1	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:82580057G>C	uc003uhx.2	-	6	10136	c.9847C>G	c.(9847-9849)CAG>GAG	p.Q3283E	PCLO_uc003uhv.2_Missense_Mutation_p.Q3283E|PCLO_uc010lec.2_Missense_Mutation_p.Q248E	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3214	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AACGTCTCCTGCCTCATCATG	0.483													19	175					0	0	0	0	C	82580057	C	C	82580057	3	2	242	1	0	0	0	0	1	0	0	0	11637	1328	46	4	5678	4	PCLO	7	82580057	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	11008879	82580057	76558606	118	44489											
SAMD9	54809	broad.mit.edu	37	chr7	92733867	92733867	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacatcagaagctctttctCtttgccaggaacttggatca	10	13	8	10	0	4	2	2	1	2	1	5	4	4	4	1	2	3	1	1	2	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:92733867C>A	uc003umf.2	-	3	1800	c.1544G>T	c.(1543-1545)AGA>ATA	p.R515I	SAMD9_uc003umg.2_Missense_Mutation_p.R515I	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	515						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			AGCTCTTTCTCTTTGCCAGGA	0.388													15	156					1.3612e-06	3.60265e-06	1	0	A	92733867	A	A	92733867	3	1	242	1	0	0	0	0	1	0	0	0	13891	913	32	2	3229	2	SAMD9	7	92733867	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	10153810	92733867	66404796	119	44490											
SAMD9L	219285	broad.mit.edu	37	chr7	92762801	92762801	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attaccaatgttttttcataTcgcaaatccttttctgctaa	11	18	3	9	1	2	0	1	0	1	0	4	0	3	0	2	0	2	3	2	0	5	8			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:92762801T>C	uc003umh.1	-	5	3700	c.2484A>G	c.(2482-2484)CGA>CGG	p.R828R	SAMD9L_uc003umj.1_Silent_p.R828R|SAMD9L_uc003umi.1_Silent_p.R828R|SAMD9L_uc010lfb.1_Silent_p.R828R|SAMD9L_uc003umk.1_Silent_p.R828R|SAMD9L_uc010lfc.1_Silent_p.R828R|SAMD9L_uc010lfd.1_Silent_p.R828R|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	828										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTTTTCATATCGCAAATCCT	0.358													93	58					0	0	0	0	C	92762801	C	C	92762801	2	2	242	1	0	0	0	0	0	0	0	1	13892	1422	50	5		5	SAMD9L	7	92762801	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08	28934	92762801	66375862	120	44491											
HEPACAM2	253012	broad.mit.edu	37	chr7	92837946	92837946	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catcttgcctgccggttatgTtgttgtaagcacagcacaca	9	12	9	11	1	1	0	0	0	1	0	1	0	1	0	2	1	4	6	2	1	2	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:92837946T>C	uc003umm.2	-	4	982	c.959A>G	c.(958-960)AAC>AGC	p.N320S	HEPACAM2_uc003uml.2_Missense_Mutation_p.N308S|HEPACAM2_uc010lff.2_Missense_Mutation_p.N308S|HEPACAM2_uc011khy.1_Missense_Mutation_p.N343S	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	320	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						GCCGGTTATGTTGTTGTAAGC	0.408													11	159					0	0	0	0	C	92837946	C	C	92837946	3	2	242	1	0	0	0	0	1	0	0	0	7092	1725	60	5	457	5	HEPACAM2	7	92837946	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	75145	92837946	66300717	121	44492											
TMEM130	222865	broad.mit.edu	37	chr7	98449123	98449123	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cggatgctgaagcagtagtcCccagggtccctgaaggtgtg	8	8	15	10	1	0	2	0	2	0	0	2	3	2	3	3	3	2	3	3	3	3	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:98449123C>T	uc003upo.2	-	6	1116	c.927G>A	c.(925-927)GGG>GGA	p.G309G	TMEM130_uc011kiq.1_Silent_p.G290G|TMEM130_uc011kir.1_Silent_p.G309G|TMEM130_uc003upn.2_Silent_p.G207G	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	309	Extracellular (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGCAGTAGTCCCCAGGGTCCC	0.592													61	42					0	0	0	0	T	98449123	T	T	98449123	2	4	242	1	0	0	0	0	0	0	0	1	16109	610	22	4		4	TMEM130	7	98449123	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	5611177	98449123	60689540	122	44493											
RELN	5649	broad.mit.edu	37	chr7	103126741	103126742	+	Frame_Shift_Ins	INS	-	A	A																															gcgtagggggccagctgcccINSacagccacttcctatgactc																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:103126741_103126742insA	uc003vca.2	-	61	10045_10046	c.9885_9886insT	c.(9883-9888)TGTGGGfs	p.C3295fs	RELN_uc010liz.2_Frame_Shift_Ins_p.C3295fs	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3295_3296					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GCCAGCTGCCCACAGCCACTTC	0.515													---	---	---								A	103126742	A	A	103126741	7	5	242	1	0	1	1	0	0	0	0	0	13285	594	21	0	516	0	RELN	7	103126741	Frame_Shift_Ins	INS	-	TCGA-CV-7254-01A-11D-2012-08	4677618	103126741	56011922	123	44494											
C7orf60	154743	broad.mit.edu	37	chr7	112555359	112555359	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttaattcataaaagtacttAcctacaacaccattcaatac	17	12	2	10	0	2	0	2	0	0	0	2	0	2	0	2	0	5	2	2	0	9	8			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:112555359A>G	uc003vgo.1	-	2	429	c.302_splice	c.e2+1	p.S101_splice	C7orf60_uc011kms.1_Splice_Site_p.S127_splice	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743											ovary(2)|skin(1)	3						AAAAGTACTTACCTACAACAC	0.259													32	52					0	0	0	0	G	112555359	G	G	112555359	5	3	242	1	0	0	0	0	0	0	1	0	2418	405	14	5	929	5	C7orf60	7	112555359	Splice_Site	SNP	A	TCGA-CV-7254-01A-11D-2012-08	9428618	112555359	46583304	124	44495											
ANKRD7	56311	broad.mit.edu	37	chr7	117874864	117874864	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcttcactatgctgtttgtgGtcaaagtttgtcattagttg	7	19	9	6	0	4	0	3	0	1	0	4	0	4	0	0	1	1	4	0	1	3	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:117874864G>A	uc003vji.2	+	3	577	c.404G>A	c.(403-405)GGT>GAT	p.G135D		NM_019644	NP_062618	Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	135	ANK 3.				male gonad development						0						GCTGTTTGTGGTCAAAGTTTG	0.333													24	43					0	0	0	0	A	117874864	A	A	117874864	3	1	242	1	0	0	0	0	1	0	0	0	686	1261	44	4	414	4	ANKRD7	7	117874864	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	5319505	117874864	41263799	125	44496											
PLXNA4	91584	broad.mit.edu	37	chr7	132192549	132192549	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggtactccaccccactgcGctcacagccaatgggcacct	8	6	9	18	2	1	0	1	0	0	0	2	0	2	0	5	2	3	3	5	2	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:132192549G>C	uc003vra.3	-	2	1133	c.904C>G	c.(904-906)CGC>GGC	p.R302G	PLXNA4_uc003vrc.2_Missense_Mutation_p.R302G|PLXNA4_uc003vrb.2_Missense_Mutation_p.R302G	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	302	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						ACCCCACTGCGCTCACAGCCA	0.592													11	41					0	0	0	0	C	132192549	C	C	132192549	3	2	242	1	0	0	0	0	1	0	0	0	12177	1087	38	3	5218	3	PLXNA4	7	132192549	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	14317685	132192549	26946114	126	44497											
MGAM	8972	broad.mit.edu	37	chr7	141794549	141794549	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatttcctcttgtttcagacGggagcagatatctgtgggtt	7	16	11	7	1	3	2	1	0	2	2	4	3	4	3	1	2	1	3	1	2	2	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:141794549G>T	uc003vwy.2	+	40	4710	c.4656G>T	c.(4654-4656)ACG>ACT	p.T1552T		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1552	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TGTTTCAGACGGGAGCAGATA	0.473													8	46					1.06961e-07	2.92853e-07	1	0	T	141794549	T	T	141794549	2	4	242	1	0	0	0	0	0	0	0	1	9594	1103	39	3		3	MGAM	7	141794549	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	9602000	141794549	17344114	127	44498											
KCNH2	3757	broad.mit.edu	37	chr7	150647315	150647315	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggagccccgggagatgaagTacagggcggtgagcaggtcc	9	5	18	9	2	0	3	0	2	0	1	1	5	1	4	3	5	3	2	3	5	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr7:150647315T>A	uc003wic.2	-	9	2352	c.2339A>T	c.(2338-2340)TAC>TTC	p.Y780F	KCNH2_uc003wib.2_Missense_Mutation_p.Y440F|KCNH2_uc011kux.1_Missense_Mutation_p.Y684F|KCNH2_uc003wid.2_Missense_Mutation_p.Y440F|KCNH2_uc003wie.2_Missense_Mutation_p.Y780F	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	780	Cytoplasmic (Potential).|cNMP.				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GGAGATGAAGTACAGGGCGGT	0.652													12	128					0	0	0	0	A	150647315	A	A	150647315	3	1	242	1	0	0	0	0	1	0	0	0	8071	1638	57	5	1437	5	KCNH2	7	150647315	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	8852766	150647315	8491348	128	44499											
SGCZ	137868	broad.mit.edu	37	chr8	13948034	13948034	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtaaagtttgccattggggCagacgcagagttcatacact	11	10	12	8	1	1	2	1	0	0	2	1	2	1	2	1	3	2	5	1	3	3	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr8:13948034C>G	uc003wwq.2	-	8	1517	c.857G>C	c.(856-858)TGC>TCC	p.C286S	SGCZ_uc010lss.2_Missense_Mutation_p.C239S	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	273	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GCCATTGGGGCAGACGCAGAG	0.498													15	69					0	0	0	0	G	13948034	G	G	13948034	3	3	242	1	0	0	0	0	1	0	0	0	14269	710	25	4	85	4	SGCZ	8	13948034	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08		13948034	132415988	129	44500											
STC1	6781	broad.mit.edu	37	chr8	23702425	23702425	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtgtgtttgggcacagTggtctgtctgcaggatgtgg	4	13	19	5	0	2	0	0	0	2	0	2	1	2	1	0	5	1	3	0	5	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr8:23702425T>G	uc003xdw.1	-	4	886	c.602A>C	c.(601-603)CAC>CCC	p.H201P		NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor	201					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TTGGGCACAGTGGTCTGTCTG	0.542													13	48					0	0	0	0	G	23702425	G	G	23702425	3	3	242	1	0	0	0	0	1	0	0	0	15341	1696	59	5	145	5	STC1	8	23702425	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	9754391	23702425	122661597	130	44501											
ADAM2	2515	broad.mit.edu	37	chr8	39682379	39682379	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcataattcctgtgccacTataactgtaaactctaaaat	14	15	3	9	0	2	0	1	0	1	0	3	0	3	0	2	0	3	1	2	0	7	7			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr8:39682379T>C	uc003xnj.2	-	4	301	c.226A>G	c.(226-228)AGT>GGT	p.S76G	ADAM2_uc003xnk.2_Missense_Mutation_p.S76G|ADAM2_uc011lck.1_Missense_Mutation_p.S76G|ADAM2_uc003xnl.2_Missense_Mutation_p.S76G	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	76					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CCTGTGCCACTATAACTGTAA	0.274													8	30					0	0	0	0	C	39682379	C	C	39682379	3	2	242	1	0	0	0	0	1	0	0	0	241	1522	53	5	2049	5	ADAM2	8	39682379	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	15979954	39682379	106681643	131	44502											
CHRNB3	1142	broad.mit.edu	37	chr8	42563960	42563960	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccctgtattacattctaaTgacaccataaaagtatattt	14	14	4	9	1	1	1	0	1	1	0	1	1	1	1	2	0	1	2	2	0	7	8			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr8:42563960T>C	uc003xpi.1	+	2	281	c.153T>C	c.(151-153)AAT>AAC	p.N51N		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	51	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TACATTCTAATGACACCATAA	0.408													32	56					0	0	0	0	C	42563960	C	C	42563960	2	2	242	1	0	0	0	0	0	0	0	1	3407	1461	51	5		5	CHRNB3	8	42563960	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08	2881581	42563960	103800062	132	44503											
ASPH	444	broad.mit.edu	37	chr8	62438587	62438587	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctttttccctcaggttttCatcctcaggcaggaagagac	8	12	8	13	0	3	1	3	0	0	1	5	3	5	2	3	3	0	2	3	3	1	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr8:62438587C>T	uc003xuj.2	-	22	2118	c.1849G>A	c.(1849-1851)GAA>AAA	p.E617K	ASPH_uc011leg.1_Missense_Mutation_p.E588K	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	617	Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	CTCAGGTTTTCATCCTCAGGC	0.483													47	113					0	0	0	0	T	62438587	T	T	62438587	3	4	242	1	0	0	0	0	1	0	0	0	1055	835	29	2	443	2	ASPH	8	62438587	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	19874627	62438587	83925435	133	44504											
SLC7A13	157724	broad.mit.edu	37	chr8	87242004	87242004	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgaagctaagtatggacActttcagcactgagctagct	14	10	9	8	0	1	2	1	2	0	0	1	3	1	3	0	1	4	5	0	1	5	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr8:87242004A>G	uc003ydq.1	-	1	601	c.503T>C	c.(502-504)GTG>GCG	p.V168A	SLC7A13_uc003ydr.1_Missense_Mutation_p.V168A	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	168	Helical; Name=5; (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						AAGTATGGACACTTTCAGCAC	0.418													17	72					0	0	0	0	G	87242004	G	G	87242004	3	3	242	1	0	0	0	0	1	0	0	0	14759	159	6	5	925	5	SLC7A13	8	87242004	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	24803417	87242004	59122018	134	44505											
CSMD3	114788	broad.mit.edu	37	chr8	113301698	113301698	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggaatagtgaacagtaGacccaaaagtatacttctcg	15	9	9	8	1	1	2	0	1	1	1	2	3	1	3	1	1	3	3	1	1	8	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr8:113301698G>T	uc003ynu.2	-	57	9203	c.9044C>A	c.(9043-9045)TCT>TAT	p.S3015Y	CSMD3_uc003yns.2_Missense_Mutation_p.S2217Y|CSMD3_uc003ynt.2_Missense_Mutation_p.S2975Y|CSMD3_uc011lhx.1_Missense_Mutation_p.S2846Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3015	Sushi 21.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTGAACAGTAGACCCAAAAGT	0.423										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			20	67					6.33239e-15	1.9488e-14	1	0	T	113301698	T	T	113301698	3	4	242	1	0	0	0	0	1	0	0	0	3963	942	33	2	2139	2	CSMD3	8	113301698	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	26059694	113301698	33062324	135	44506											
ASAP1	50807	broad.mit.edu	37	chr8	131070203	131070203	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggatattcgtacgtacccaCcactcctggtcctcttcccc	6	12	6	17	2	1	0	0	0	1	0	5	1	4	1	6	2	2	2	6	2	3	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr8:131070203C>A	uc003yta.1	-	28	3340	c.3312G>T	c.(3310-3312)TGG>TGT	p.W1104C	ASAP1_uc003ysz.1_Missense_Mutation_p.W915C|ASAP1_uc011liw.1_Missense_Mutation_p.W1097C	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	1104	SH3.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TACGTACCCACCACTCCTGGT	0.512													68	94					6.20995e-33	2.02078e-32	1	0	A	131070203	A	A	131070203	3	1	242	1	0	0	0	0	1	0	0	0	1012	508	18	4	85	4	ASAP1	8	131070203	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	17768505	131070203	15293819	136	44507											
COL22A1	169044	broad.mit.edu	37	chr8	139728521	139728521	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagcctggagcccctgggagGcctgcttctccctgtgagaa	7	8	13	13	0	1	1	0	1	1	1	2	4	1	3	5	3	3	1	5	3	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr8:139728521G>T	uc003yvd.2	-	29	2859	c.2412C>A	c.(2410-2412)GGC>GGA	p.G804G	COL22A1_uc011ljo.1_Silent_p.G104G	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	804	Pro-rich.|Gly-rich.|Collagen-like 6.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCCCTGGGAGGCCTGCTTCTC	0.587										HNSCC(7;0.00092)			3	12					6.4e-05	0.000160338	1	0	T	139728521	T	T	139728521	2	4	242	1	0	0	0	0	0	0	0	1	3696	1190	42	4		4	COL22A1	8	139728521	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	8658318	139728521	6635501	137	44508											
CDKN2A	1029	broad.mit.edu	37	chr9	21971029	21971029	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccacgggcagacggcccCaggcatcgcgcacgtccagc	7	3	14	17	5	0	1	0	0	0	1	3	1	2	1	4	4	1	3	4	4	0	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr9:21971029C>T	uc003zpk.2	-	2	541	c.329G>A	c.(328-330)TGG>TAG	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.L165L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGACGGCCCCAGGCATCGCG	0.731		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			42	19					0	0	0	0	T	21971029	T	T	21971029	4	4	242	1	0	0	0	0	0	1	0	0	3176	595	21	4	149	4	CDKN2A	9	21971029	Nonsense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08		21971029	119242402	138	44509											
DNAI1	27019	broad.mit.edu	37	chr9	34490414	34490414	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgactcctaagcagccCaaggagagaaagctcactaa	15	7	9	10	0	1	3	1	2	0	1	2	5	2	4	2	1	3	2	2	1	4	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr9:34490414C>A	uc003zum.2	+	7	742	c.549C>A	c.(547-549)CCC>CCA	p.P183P		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	183					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		CTAAGCAGCCCAAGGAGAGAA	0.498									Kartagener_syndrome				230	120					5.95591e-76	1.98697e-75	1	0	A	34490414	A	A	34490414	2	1	242	1	0	0	0	0	0	0	0	1	4631	581	21	4		4	DNAI1	9	34490414	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	12519385	34490414	106723017	139	44510											
TJP2	9414	broad.mit.edu	37	chr9	71845073	71845073	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gctggtggcaatgatgtcggGatatttgttgctggcattca	7	14	14	6	1	1	1	1	1	0	0	2	2	1	2	0	4	1	5	0	4	2	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr9:71845073G>C	uc004ahe.2	+	11	1796	c.1596G>C	c.(1594-1596)GGG>GGC	p.G532G	TJP2_uc011lrs.1_Silent_p.G509G|TJP2_uc011lrt.1_Silent_p.G509G|TJP2_uc004ahd.2_Silent_p.G532G|TJP2_uc004ahf.2_Silent_p.G532G|TJP2_uc011lru.1_Silent_p.G536G|TJP2_uc011lrv.1_Silent_p.G554G	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	532	PDZ 3.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						ATGATGTCGGGATATTTGTTG	0.517													40	67					0	0	0	0	C	71845073	C	C	71845073	2	2	242	1	0	0	0	0	0	0	0	1	15996	1161	41	2		2	TJP2	9	71845073	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	37354659	71845073	69368358	140	44511											
TJP2	9414	broad.mit.edu	37	chr9	71866155	71866155	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagggtgaggaggtgggaGagagcagtgaggagcaagat	14	4	21	2	0	0	5	0	2	0	3	0	9	0	8	0	5	2	2	0	5	2	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr9:71866155G>T	uc004ahe.2	+	21	3396	c.3196G>T	c.(3196-3198)GAG>TAG	p.E1066*	TJP2_uc011lrs.1_Intron|TJP2_uc004ahf.2_Intron|TJP2_uc011lru.1_Nonsense_Mutation_p.E1033*|TJP2_uc011lrv.1_Nonsense_Mutation_p.E1088*|TJP2_uc010mom.1_Intron	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	1066					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						GGAGGTGGGAGAGAGCAGTGA	0.502													17	35					8.60227e-14	2.5872e-13	1	0	T	71866155	T	T	71866155	4	4	242	1	0	0	0	0	0	1	0	0	15996	943	33	2	3537	2	TJP2	9	71866155	Nonsense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	21082	71866155	69347276	141	44512											
TRPM6	140803	broad.mit.edu	37	chr9	77436731	77436731	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttccaccaccagccccacGaccggcacgccttgtcttga	7	7	7	20	3	1	1	0	1	1	0	2	2	2	1	8	1	1	1	8	1	0	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr9:77436731G>T	uc004ajl.1	-	8	1102	c.864C>A	c.(862-864)GTC>GTA	p.V288V	TRPM6_uc004ajk.1_Silent_p.V283V|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Silent_p.V288V|TRPM6_uc010mpd.1_Silent_p.V288V|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	288	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CCAGCCCCACGACCGGCACGC	0.572													19	29					5.03518e-11	1.46983e-10	1	0	T	77436731	T	T	77436731	2	4	242	1	0	0	0	0	0	0	0	1	16657	1045	37	3		3	TRPM6	9	77436731	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	5570576	77436731	63776700	142	44513											
PTPN3	5774	broad.mit.edu	37	chr9	112189263	112189263	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagcccatagtccagtacTgagacagaacattcttttcc	12	10	8	11	0	1	3	0	1	1	3	3	5	3	3	3	0	3	1	3	0	3	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr9:112189263T>G	uc004bed.2	-	12	1080	c.968A>C	c.(967-969)CAG>CCG	p.Q323P	PTPN3_uc004beb.2_Missense_Mutation_p.Q192P|PTPN3_uc004bec.2_Missense_Mutation_p.Q192P|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.Q323P|PTPN3_uc011lwh.1_Missense_Mutation_p.Q214P|PTPN3_uc011lwe.1_Missense_Mutation_p.Q36P|PTPN3_uc011lwf.1_Missense_Mutation_p.Q36P	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	323					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						AGTCCAGTACTGAGACAGAAC	0.438													37	43					0	0	0	0	G	112189263	G	G	112189263	3	3	242	1	0	0	0	0	1	0	0	0	12854	1580	55	5	1833	5	PTPN3	9	112189263	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	34752532	112189263	29024168	143	44514											
PTGS1	5742	broad.mit.edu	37	chr9	125154726	125154726	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactgaagaagctggtctGcctcaacaccaagacctgtc	12	7	8	14	0	2	3	1	1	1	2	3	3	2	3	3	1	3	1	3	1	4	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr9:125154726G>T	uc004bmg.1	+	11	1838	c.1703G>T	c.(1702-1704)TGC>TTC	p.C568F	PTGS1_uc011lys.1_Missense_Mutation_p.C506F|PTGS1_uc010mwb.1_Missense_Mutation_p.C422F|PTGS1_uc004bmf.1_Missense_Mutation_p.C531F|PTGS1_uc004bmh.1_Missense_Mutation_p.C459F|PTGS1_uc011lyt.1_Missense_Mutation_p.C459F	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	568					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	AAGCTGGTCTGCCTCAACACC	0.577													40	65					1.49673e-21	4.75362e-21	1	0	T	125154726	T	T	125154726	3	4	242	1	0	0	0	0	1	0	0	0	12818	1319	46	4	1745	4	PTGS1	9	125154726	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	12965463	125154726	16058705	144	44515											
PKN3	29941	broad.mit.edu	37	chr9	131482522	131482522	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagcgcctcggggcaggtgAgcaggatgccgaggagatca	10	4	18	9	3	1	2	1	1	0	1	2	6	1	3	2	5	3	2	2	5	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr9:131482522A>G	uc004bvw.2	+	21	2810	c.2417A>G	c.(2416-2418)GAG>GGG	p.E806G	PKN3_uc010myh.2_Intron|PKN3_uc011mbk.1_Missense_Mutation_p.E356G	NM_013355	NP_037487	Q6P5Z2	PKN3_HUMAN	protein kinase PKNbeta	806	Protein kinase.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			stomach(2)|lung(2)	4						GGGGCAGGTGAGCAGGATGCC	0.642													21	20					0	0	0	0	G	131482522	G	G	131482522	3	3	242	1	0	0	0	0	1	0	0	0	12036	304	11	5	2499	5	PKN3	9	131482522	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	6327796	131482522	9730909	145	44516											
ABL1	25	broad.mit.edu	37	chr9	133738362	133738362	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgggcgggggccagtacggGgaggtgtacgagggcgtgtg	5	6	23	7	4	0	0	0	0	0	0	0	2	0	1	1	7	2	2	1	7	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr9:133738362G>A	uc004bzw.2	+	4	765	c.762G>A	c.(760-762)GGG>GGA	p.G254G	ABL1_uc004bzv.2_Silent_p.G273G|uc004bzx.1_5'Flank	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	254	Protein kinase.|ATP.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GCCAGTACGGGGAGGTGTACG	0.617			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								10	40					0	0	0	0	A	133738362	A	A	133738362	2	1	242	1	0	0	0	0	0	0	0	1	92	1219	43	4		4	ABL1	9	133738362	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	2255840	133738362	7475069	146	44517											
KIN	22944	broad.mit.edu	37	chr10	7808047	7808047	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtagtctgttcgggcagttCttttcttttcctcttcaatc	5	19	7	10	1	5	0	1	0	4	0	8	0	6	0	1	1	0	4	1	1	2	8			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:7808047C>G	uc001ijt.2	-	9	866	c.818G>C	c.(817-819)AGA>ACA	p.R273T	KIN_uc010qaz.1_RNA|KIN_uc009xip.2_Missense_Mutation_p.R273T|KIN_uc010qba.1_Missense_Mutation_p.R167T	NM_012311	NP_036443	O60870	KIN17_HUMAN	HsKin17 protein	273	Potential.				DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TCGGGCAGTTCTTTTCTTTTC	0.328													6	42					0	0	0	0	G	7808047	G	G	7808047	3	3	242	1	0	0	0	0	1	0	0	0	8354	913	32	2	383	2	KIN	10	7808047	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08		7808047	127726700	147	44518											
ITGA8	8516	broad.mit.edu	37	chr10	15688977	15688977	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaaatacaggtagatttGccctacttctctggggttgc	8	14	10	9	0	1	1	0	0	1	1	2	1	1	1	1	3	5	3	1	3	4	7			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:15688977G>T	uc001ioc.1	-	12	1075	c.1075C>A	c.(1075-1077)CAA>AAA	p.Q359K	ITGA8_uc010qcb.1_Missense_Mutation_p.Q344K	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	359	Extracellular (Potential).|FG-GAP 5.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						AGGTAGATTTGCCCTACTTCT	0.502													18	101					5.03518e-11	1.46983e-10	1	0	T	15688977	T	T	15688977	3	4	242	1	0	0	0	0	1	0	0	0	7921	1328	46	4	2192	4	ITGA8	10	15688977	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	7880930	15688977	119845770	148	44519											
ARHGAP21	57584	broad.mit.edu	37	chr10	24896427	24896427	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aataatacacccgagacttaCaattttgcatcttctctgta	13	14	4	10	1	2	1	0	0	2	1	3	2	2	1	1	0	3	2	1	0	6	7			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:24896427C>T	uc001isb.2	-	11	3171	c.2684_splice	c.e11+1	p.L895_splice	ARHGAP21_uc010qdb.1_Splice_Site|ARHGAP21_uc009xkl.1_Splice_Site_p.L895_splice|ARHGAP21_uc010qdc.1_Splice_Site_p.L730_splice	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21						signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						CCGAGACTTACAATTTTGCAT	0.388													7	73					0	0	0	0	T	24896427	T	T	24896427	5	4	242	1	0	0	0	0	0	0	1	0	871	492	17	4	3255	4	ARHGAP21	10	24896427	Splice_Site	SNP	C	TCGA-CV-7254-01A-11D-2012-08	9207450	24896427	110638320	149	44520											
ANKRD30A	91074	broad.mit.edu	37	chr10	37508752	37508752	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcctaaaagagaaaaatgAggagatatttaattacaata	20	11	6	4	0	1	3	0	1	1	2	2	5	1	3	1	1	1	0	1	1	9	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:37508752A>T	uc001iza.1	+	34	4043	c.3944A>T	c.(3943-3945)GAG>GTG	p.E1315V		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1371						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GAGAAAAATGAGGAGATATTT	0.274													5	12					0	0	0	0	T	37508752	T	T	37508752	3	4	242	1	0	0	0	0	1	0	0	0	658	304	11	5	4078	5	ANKRD30A	10	37508752	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	12612325	37508752	98025995	150	44521											
C10orf71	118461	broad.mit.edu	37	chr10	50532083	50532083	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacaagtccaaagcccctaGcctgctgttcaacctcaagg	11	8	7	15	0	2	0	2	0	0	0	3	0	3	0	5	1	5	2	5	1	6	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:50532083G>C	uc010qgp.1	+	3	1832	c.1493G>C	c.(1492-1494)AGC>ACC	p.S498T		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	498											0						AAAGCCCCTAGCCTGCTGTTC	0.512													4	20					0	0	0	0	C	50532083	C	C	50532083	3	2	242	1	0	0	0	0	1	0	0	0	1620	971	34	4	1495	4	C10orf71	10	50532083	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	13023331	50532083	85002664	151	44522											
TET1	80312	broad.mit.edu	37	chr10	70450631	70450631	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accccattttatcttaaaaaGttcagacaacactaaaactt	17	12	2	10	0	2	1	1	0	1	1	2	1	2	1	2	0	2	1	2	0	7	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:70450631G>T	uc001jok.3	+	12	5976	c.5471G>T	c.(5470-5472)AGT>ATT	p.S1824I		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1824					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						ATCTTAAAAAGTTCAGACAAC	0.453													14	68					9.31168e-06	2.40048e-05	1	0	T	70450631	T	T	70450631	3	4	242	1	0	0	0	0	1	0	0	0	15835	1029	36	4	5513	4	TET1	10	70450631	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	19918548	70450631	65084116	152	44523											
SRGN	5552	broad.mit.edu	37	chr10	70847958	70847958	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcggcttgtcctggctctTgccctcatcctggttctgga	3	14	11	13	1	3	0	1	0	2	0	6	1	5	1	3	4	1	3	3	4	0	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:70847958T>C	uc001joz.2	+	1	131	c.45T>C	c.(43-45)CTT>CTC	p.L15L	SRGN_uc001jpa.1_RNA	NM_002727	NP_002718	P10124	SRGN_HUMAN	serglycin precursor	15					apoptosis|biomineral tissue development|maintenance of granzyme B location in T cell secretory granule|maintenance of protease location in mast cell secretory granule|negative regulation of bone mineralization|negative regulation of cytokine secretion|platelet activation|platelet degranulation|protein maturation by peptide bond cleavage	extracellular space|mast cell granule|platelet alpha granule lumen					0						TCCTGGCTCTTGCCCTCATCC	0.493													17	69					0	0	0	0	C	70847958	C	C	70847958	2	2	242	1	0	0	0	0	0	0	0	1	15214	1799	63	5		5	SRGN	10	70847958	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08	397327	70847958	64686789	153	44524											
ANXA11	311	broad.mit.edu	37	chr10	81915641	81915641	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacagatcttcagcagaaTcttccggtaatcccctgaag	12	9	7	13	1	3	3	1	1	2	2	5	3	5	3	4	1	1	2	4	1	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:81915641T>A	uc001kbq.1	-	17	2311	c.1486A>T	c.(1486-1488)ATT>TTT	p.I496F	ANXA11_uc010qlx.1_Missense_Mutation_p.I596F|ANXA11_uc001kbr.1_Missense_Mutation_p.I496F|ANXA11_uc001kbs.1_Missense_Mutation_p.I496F|ANXA11_uc001kbt.1_Missense_Mutation_p.I496F|ANXA11_uc010qly.1_Missense_Mutation_p.I463F|ANXA11_uc009xsq.1_Missense_Mutation_p.I500F|ANXA11_uc001kbu.1_Missense_Mutation_p.I496F	NM_145869	NP_665876	P50995	ANX11_HUMAN	annexin A11	496	Annexin 4.				cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding			ovary(1)	1	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			TTCAGCAGAATCTTCCGGTAA	0.517													36	117					0	0	0	0	A	81915641	A	A	81915641	3	1	242	1	0	0	0	0	1	0	0	0	716	1435	50	5	35	5	ANXA11	10	81915641	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	11067683	81915641	53619106	154	44525											
SLC16A12	387700	broad.mit.edu	37	chr10	91193071	91193071	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgtagctgccggtggtaTctaccagccgtcctgtaaca	8	10	11	12	2	1	0	0	0	1	0	2	0	2	0	4	2	5	4	4	2	4	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:91193071T>A	uc001kgm.2	-	8	1602	c.1211A>T	c.(1210-1212)GAT>GTT	p.D404V	SLC16A12_uc001kgl.2_Missense_Mutation_p.D76V	NM_213606	NP_998771	Q6ZSM3	MOT12_HUMAN	solute carrier family 16 (monocarboxylic acid	404	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			skin(1)	1						GCCGGTGGTATCTACCAGCCG	0.368													8	31					0	0	0	0	A	91193071	A	A	91193071	3	1	242	1	0	0	0	0	1	0	0	0	14470	1435	50	5	253	5	SLC16A12	10	91193071	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	9277430	91193071	44341676	155	44526											
ZNF518A	9849	broad.mit.edu	37	chr10	97916167	97916167	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaaaaatgagatagttgatAggtcggcacctaaaccaaaa	18	8	9	6	1	0	3	0	3	0	1	1	4	0	3	2	2	1	2	2	2	8	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:97916167A>C	uc001klp.2	+	6	945	c.88A>C	c.(88-90)AGG>CGG	p.R30R	ZNF518A_uc001klo.1_Intron|ZNF518A_uc001klq.2_Silent_p.R30R|ZNF518A_uc001klr.2_Silent_p.R30R	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	30					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		GATAGTTGATAGGTCGGCACC	0.279													11	49					0	0	0	0	C	97916167	C	C	97916167	2	2	242	1	0	0	0	0	0	0	0	1	18029	411	15	5		5	ZNF518A	10	97916167	Silent	SNP	A	TCGA-CV-7254-01A-11D-2012-08	6723096	97916167	37618580	156	44527											
SEC31B	25956	broad.mit.edu	37	chr10	102267289	102267289	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacagcactaactgggtggcTatgtcaggatgccaggccag	10	7	13	11	0	1	0	1	0	0	0	1	1	1	1	2	4	3	2	2	4	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:102267289T>A	uc001krc.1	-	7	777	c.675A>T	c.(673-675)ATA>ATT	p.I225I	SEC31B_uc010qpo.1_Silent_p.I224I|SEC31B_uc001krd.1_5'UTR|SEC31B_uc001krf.1_5'UTR|SEC31B_uc001kre.1_5'UTR|SEC31B_uc001krg.1_Intron|SEC31B_uc010qpp.1_Silent_p.I228I|SEC31B_uc009xwn.1_Silent_p.I225I|SEC31B_uc009xwo.1_Silent_p.I225I|SEC31B_uc010qpq.1_Silent_p.I68I|SEC31B_uc010qpr.1_RNA	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	225	WD 4.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		ACTGGGTGGCTATGTCAGGAT	0.557													18	58					0	0	0	0	A	102267289	A	A	102267289	2	1	242	1	0	0	0	0	0	0	0	1	14064	1512	53	5		5	SEC31B	10	102267289	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08	4351122	102267289	33267458	157	44528											
NEURL	9148	broad.mit.edu	37	chr10	105349976	105349976	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgatgagtgcaccatttgCtatgaacacgcggtggacac	11	8	12	10	3	0	2	0	2	0	0	0	4	0	3	1	2	4	2	1	2	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:105349976C>T	uc001kxh.2	+	6	1982	c.1572C>T	c.(1570-1572)TGC>TGT	p.C524C	SH3PXD2A_uc010qqr.1_Intron	NM_004210	NP_004201	O76050	NEU1A_HUMAN	neuralized-like	524	RING-type.				nervous system development	perinuclear region of cytoplasm	zinc ion binding				0				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		GCACCATTTGCTATGAACACG	0.632													14	75					0	0	0	0	T	105349976	T	T	105349976	2	4	242	1	0	0	0	0	0	0	0	1	10399	805	28	4		4	NEURL	10	105349976	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	3082687	105349976	30184771	158	44529											
MXI1	4601	broad.mit.edu	37	chr10	112039820	112039820	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattggatcaactatttcttCagatcgttctgattcagagc	10	15	7	9	1	5	3	3	1	2	2	6	4	5	4	0	1	2	1	0	1	2	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:112039820C>T	uc001kza.2	+	5	707	c.500C>T	c.(499-501)TCA>TTA	p.S167L	MXI1_uc001kyy.2_Missense_Mutation_p.S234L|MXI1_uc001kyz.2_Missense_Mutation_p.S121L|MXI1_uc010qrc.1_Missense_Mutation_p.S157L|MXI1_uc009xxu.2_Missense_Mutation_p.S164L|MXI1_uc009xxv.2_RNA	NM_005962	NP_005953	P50539	MXI1_HUMAN	MAX interactor 1 isoform a	167					cytoplasmic sequestering of transcription factor|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;1.33e-05)|all cancers(201;0.000277)|BRCA - Breast invasive adenocarcinoma(275;0.127)		ACTATTTCTTCAGATCGTTCT	0.448													9	43					0	0	0	0	T	112039820	T	T	112039820	3	4	242	1	0	0	0	0	1	0	0	0	10055	838	29	2	796	2	MXI1	10	112039820	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	6689844	112039820	23494927	159	44530											
TECTB	6975	broad.mit.edu	37	chr10	114053774	114053774	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagctgttgggccaccccctCggctgacttcatgtatccct	5	11	9	16	1	1	1	1	1	0	0	3	1	2	1	4	2	1	4	4	2	1	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:114053774C>T	uc001kzr.1	+	6	626	c.626C>T	c.(625-627)TCG>TTG	p.S209L		NM_058222	NP_478129	Q96PL2	TECTB_HUMAN	tectorin beta precursor	209	ZP.					anchored to membrane|plasma membrane|proteinaceous extracellular matrix					0		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		GCCACCCCCTCGGCTGACTTC	0.468													19	44					0	0	0	0	T	114053774	T	T	114053774	3	4	242	1	0	0	0	0	1	0	0	0	15814	893	31	1	648	1	TECTB	10	114053774	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	2013954	114053774	21480973	160	44531											
VAX1	11023	broad.mit.edu	37	chr10	118896129	118896129	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttaggccggtccaagtccaGgcccttgggcaggatgatct	7	9	13	12	1	1	1	0	1	1	0	3	2	3	2	4	5	0	1	4	5	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:118896129G>A	uc009xyx.2	-	2	528	c.283C>T	c.(283-285)CTG>TTG	p.L95L	VAX1_uc001ldb.1_Silent_p.L95L	NM_001112704	NP_001106175	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1 isoform a	95						nucleus	sequence-specific DNA binding			ovary(2)	2				all cancers(201;0.0108)		TCCAAGTCCAGGCCCTTGGGC	0.657													17	57					0	0	0	0	A	118896129	A	A	118896129	2	1	242	1	0	0	0	0	0	0	0	1	17202	991	35	4		4	VAX1	10	118896129	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	4842355	118896129	16638618	161	44532											
NSMCE4A	54780	broad.mit.edu	37	chr10	123730454	123730454	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtctgtagctttgaacttacTagagtttcaacatatcttaa	12	16	6	7	0	3	2	1	1	2	1	3	2	3	2	0	0	4	3	0	0	7	7	rs139294636	byFrequency	TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr10:123730454T>A	uc001lfs.2	-	3	531	c.501A>T	c.(499-501)CTA>CTT	p.L167L	NSMCE4A_uc009xzv.2_Silent_p.L167L|NSMCE4A_uc001lft.2_Silent_p.L8L|NSMCE4A_uc010qtu.1_Silent_p.L8L|NSMCE4A_uc001lfu.1_Silent_p.L167L	NM_017615	NP_060085	Q9NXX6	NSE4A_HUMAN	non-SMC element 4 homolog A	167											0		all_neural(114;0.138)|Glioma(114;0.222)				TTGAACTTACTAGAGTTTCAA	0.358													5	19					0	0	0	0	A	123730454	A	A	123730454	2	1	242	1	0	0	0	0	0	0	0	1	10731	1536	53	5		5	NSMCE4A	10	123730454	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08	4834325	123730454	11804293	162	44533											
PTDSS2	81490	broad.mit.edu	37	chr11	489914	489914	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagctgggcccgcaggccTggctggtggcggccatcacg	6	5	17	13	3	1	1	1	0	0	1	1	1	1	1	3	6	1	3	3	6	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:489914T>C	uc001lpj.2	+	11	1323	c.1147T>C	c.(1147-1149)TGG>CGG	p.W383R		NM_030783	NP_110410	Q9BVG9	PTSS2_HUMAN	phosphatidylserine synthase 2	383	Helical; (Potential).					integral to membrane					0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;2.76e-26)|Epithelial(43;2.56e-25)|OV - Ovarian serous cystadenocarcinoma(40;7.54e-20)|BRCA - Breast invasive adenocarcinoma(625;8.76e-05)|Lung(200;0.0407)|LUSC - Lung squamous cell carcinoma(625;0.0735)	Phosphatidylserine(DB00144)	CCCGCAGGCCTGGCTGGTGGC	0.692													5	17					0	0	0	0	C	489914	C	C	489914	3	2	242	1	0	0	0	0	1	0	0	0	12799	1580	55	5	1189	5	PTDSS2	11	489914	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08		489914	134516602	163	44534											
HBD	3045	broad.mit.edu	37	chr11	5255583	5255583	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gataccaacctgcccagggcCtcaccaccaactgcatccac	11	5	6	19	0	1	0	1	0	0	0	2	1	2	0	7	1	5	1	7	1	3	1	rs34289459		TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:5255583C>A	uc001maf.1	-	1	276	c.81G>T	c.(79-81)GAG>GAT	p.E27D		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	27					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCCAGGGCCTCACCACCAA	0.517													28	67					3.80469e-20	1.20356e-19	1	0	A	5255583	A	A	5255583	3	1	242	1	0	0	0	0	1	0	0	0	7018	680	24	4	374	4	HBD	11	5255583	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	4765669	5255583	129750933	164	44535											
OR51Q1	390061	broad.mit.edu	37	chr11	5443979	5443979	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctcgctcctattgcctccaCcaggatatgatccgcctggt	6	12	8	15	2	1	1	0	1	1	0	5	2	4	2	6	2	1	1	6	2	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:5443979C>A	uc010qzd.1	+	1	549	c.549C>A	c.(547-549)CAC>CAA	p.H183Q	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTGCCTCCACCAGGATATGA	0.512													51	168					2.74695e-27	8.90237e-27	1	0	A	5443979	A	A	5443979	3	1	242	1	0	0	0	0	1	0	0	0	11158	506	18	4	551	4	OR51Q1	11	5443979	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	188396	5443979	129562537	165	44536											
OR52B6	340980	broad.mit.edu	37	chr11	5602224	5602224	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcactggcatccctgggCtggagcaactacatatctgg	8	10	10	13	0	2	0	1	0	1	0	4	1	4	1	2	4	3	3	2	4	3	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:5602224C>G	uc010qzi.1	+	1	118	c.118C>G	c.(118-120)CTG>GTG	p.L40V	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	40	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATCCCTGGGCTGGAGCAACT	0.507													7	59					0	0	0	0	G	5602224	G	G	5602224	3	3	242	1	0	0	0	0	1	0	0	0	11167	796	28	4	120	4	OR52B6	11	5602224	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	158245	5602224	129404292	166	44537											
ILK	3611	broad.mit.edu	37	chr11	6629415	6629415	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgcatctggcagccagtCatggacaccgtgatattgta	9	10	10	12	1	2	1	1	1	1	0	2	2	2	2	3	2	2	3	3	2	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:6629415C>A	uc001mee.2	+	3	364	c.229C>A	c.(229-231)CAT>AAT	p.H77N	ILK_uc001mef.2_Missense_Mutation_p.H77N|ILK_uc010rap.1_Intron|ILK_uc010raq.1_Missense_Mutation_p.H77N|ILK_uc001meg.2_5'UTR|ILK_uc001meh.2_Missense_Mutation_p.H77N|ILK_uc001mei.2_5'Flank	NM_001014794	NP_001014794	Q13418	ILK_HUMAN	integrin-linked kinase	77	Interaction with LIMS1.|ANK 3.				cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		GGCAGCCAGTCATGGACACCG	0.527													8	74					2.17888e-05	5.54496e-05	1	0	A	6629415	A	A	6629415	3	1	242	1	0	0	0	0	1	0	0	0	7752	826	29	2	235	2	ILK	11	6629415	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	1027191	6629415	128377101	167	44538											
DCHS1	8642	broad.mit.edu	37	chr11	6662065	6662065	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctctcagacaccacagcatgGtagcggctctgattgaaagc	11	8	10	12	1	2	3	1	2	2	1	3	3	2	3	1	2	3	3	1	2	2	2	rs144400127		TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:6662065G>A	uc001mem.1	-	2	1190	c.780C>T	c.(778-780)TAC>TAT	p.Y260Y		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	260	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCACAGCATGGTAGCGGCTCT	0.602													16	113					0	0	0	0	A	6662065	A	A	6662065	2	1	242	1	0	0	0	0	0	0	0	1	4304	1256	44	4		4	DCHS1	11	6662065	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	32650	6662065	128344451	168	44539											
DCHS1	8642	broad.mit.edu	37	chr11	6662629	6662629	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtacatgagaggagctgcCgtgcctgccggaagccccgc	9	5	14	13	3	0	1	0	1	0	1	0	4	0	3	5	2	6	2	5	2	3	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:6662629C>G	uc001mem.1	-	2	626	c.216G>C	c.(214-216)ACG>ACC	p.T72T		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	72	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGGAGCTGCCGTGCCTGCCG	0.632													9	18					0	0	0	0	G	6662629	G	G	6662629	2	3	242	1	0	0	0	0	0	0	0	1	4304	639	23	3		3	DCHS1	11	6662629	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	564	6662629	128343887	169	44540											
INSC	387755	broad.mit.edu	37	chr11	15262059	15262059	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcagtgacgccgtgcttgTggcctgcctggtgagttctc	4	11	14	12	2	1	2	0	2	1	0	2	2	1	2	3	2	3	3	3	2	0	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:15262059T>G	uc001mly.2	+	12	1647	c.1601T>G	c.(1600-1602)GTG>GGG	p.V534G	INSC_uc001mlz.2_Missense_Mutation_p.V487G|INSC_uc001mma.2_Missense_Mutation_p.V487G|INSC_uc010rcs.1_Missense_Mutation_p.V522G|INSC_uc001mmb.2_Missense_Mutation_p.V487G|INSC_uc001mmc.2_Missense_Mutation_p.V445G	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	534					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						GCCGTGCTTGTGGCCTGCCTG	0.572													3	32					0	0	0	0	G	15262059	G	G	15262059	3	3	242	1	0	0	0	0	1	0	0	0	7803	1696	59	5	1647	5	INSC	11	15262059	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	8599430	15262059	119744457	170	44541											
ABCC8	6833	broad.mit.edu	37	chr11	17428485	17428485	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtcagggtcagggcgctgtCggtccacttggccagccagt	5	8	16	12	2	2	0	2	0	0	0	4	0	3	0	3	5	1	1	3	5	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:17428485C>T	uc001mnc.2	-	25	3238	c.3112G>A	c.(3112-3114)GAC>AAC	p.D1038N		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1038	ABC transmembrane type-1 2.|Extracellular (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGGGCGCTGTCGGTCCACTTG	0.652													27	78					0	0	0	0	T	17428485	T	T	17428485	3	4	242	1	0	0	0	0	1	0	0	0	58	884	31	1	1693	1	ABCC8	11	17428485	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	2166426	17428485	117578031	171	44542											
NELL1	4745	broad.mit.edu	37	chr11	21135210	21135210	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaccttcctgggttatatcGctgtgactgtgtcccaggat	7	13	10	11	1	0	1	0	1	0	0	3	2	2	2	3	2	1	2	3	2	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:21135210G>T	uc001mqe.2	+	13	1529	c.1376G>T	c.(1375-1377)CGC>CTC	p.R459L	NELL1_uc001mqf.2_Missense_Mutation_p.R459L|NELL1_uc009yid.2_Missense_Mutation_p.R487L|NELL1_uc010rdo.1_Missense_Mutation_p.R402L|NELL1_uc010rdp.1_Missense_Mutation_p.R219L	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	459	EGF-like 2; calcium-binding (Potential).				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GGGTTATATCGCTGTGACTGT	0.398													35	82					7.11191e-15	2.18025e-14	1	0	T	21135210	T	T	21135210	3	4	242	1	0	0	0	0	1	0	0	0	10387	1087	38	3	1426	3	NELL1	11	21135210	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	3706725	21135210	113871306	172	44543											
OR4C46	119749	broad.mit.edu	37	chr11	51515649	51515649	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcctatgaccactatgtggCcatctgcaagcccttgcact	8	10	9	14	0	1	1	0	1	1	0	1	1	1	1	4	2	3	2	4	2	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:51515649C>A	uc010ric.1	+	1	368	c.368C>A	c.(367-369)GCC>GAC	p.A123D		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	123	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CACTATGTGGCCATCTGCAAG	0.478													33	112					1.62565e-12	4.81628e-12	1	0	A	51515649	A	A	51515649	3	1	242	1	0	0	0	0	1	0	0	0	11105	739	26	4	370	4	OR4C46	11	51515649	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	30380439	51515649	83490867	173	44544											
OR5L2	26338	broad.mit.edu	37	chr11	55595286	55595286	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtcactgtgaatgagacaCtgctgttcctggtggccact	8	12	11	10	0	1	2	1	2	0	1	2	3	2	2	2	2	1	2	2	2	1	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:55595286C>A	uc001nhy.1	+	1	592	c.592C>A	c.(592-594)CTG>ATG	p.L198M		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				GAATGAGACACTGCTGTTCCT	0.448										HNSCC(27;0.073)			46	159					4.44401e-20	1.40022e-19	1	0	A	55595286	A	A	55595286	3	1	242	1	0	0	0	0	1	0	0	0	11225	564	20	4	594	4	OR5L2	11	55595286	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	4079637	55595286	79411230	174	44545											
OR5AP2	338675	broad.mit.edu	37	chr11	56409156	56409156	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttccaaagaatatggtgaCagccatgaggtaagaggcac	14	8	12	7	0	0	4	0	2	0	2	1	4	1	4	2	3	1	3	2	3	4	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:56409156C>A	uc001njb.1	-	1	760	c.760G>T	c.(760-762)GTC>TTC	p.V254F		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						AATATGGTGACAGCCATGAGG	0.458													18	67					6.94344e-10	1.9975e-09	1	0	A	56409156	A	A	56409156	3	1	242	1	0	0	0	0	1	0	0	0	11198	478	17	4	194	4	OR5AP2	11	56409156	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	813870	56409156	78597360	175	44546											
PRG2	5553	broad.mit.edu	37	chr11	57155327	57155327	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcaacccactgaaagcgTctgcagcgaccctggagaaa	12	5	10	14	3	2	2	1	1	1	1	2	4	2	2	3	1	4	1	3	1	3	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:57155327T>C	uc001njz.2	-	4	537	c.510A>G	c.(508-510)AGA>AGG	p.R170R	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Silent_p.R170R|PRG2_uc001nkb.2_Silent_p.R170R|PRG2_uc001nkd.2_Silent_p.R159R|PRG2_uc001nkc.2_Silent_p.R170R|PRG2_uc001nke.2_Silent_p.R450R	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	170	C-type lectin.				defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	ACTGAAAGCGTCTGCAGCGAC	0.627													7	13					0	0	0	0	C	57155327	C	C	57155327	2	2	242	1	0	0	0	0	0	0	0	1	12541	1664	58	5		5	PRG2	11	57155327	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08	746171	57155327	77851189	176	44547											
OR4D10	390197	broad.mit.edu	37	chr11	59245073	59245073	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaatctcgccttcacacGcccatgtattttttgctcca	7	15	6	13	2	2	1	1	1	1	0	4	1	3	1	3	0	1	2	3	0	2	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:59245073G>T	uc001nnz.1	+	1	171	c.171G>T	c.(169-171)ACG>ACT	p.T57T		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	57	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GCCTTCACACGCCCATGTATT	0.433													38	157					2.19358e-23	7.02299e-23	1	0	T	59245073	T	T	59245073	2	4	242	1	0	0	0	0	0	0	0	1	11108	1074	38	3		3	OR4D10	11	59245073	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	2089746	59245073	75761443	177	44548											
USP35	57558	broad.mit.edu	37	chr11	77920009	77920009	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgaagtacctgctggatcGgtaagggggccagggctacg	8	8	16	9	2	1	1	0	1	1	0	2	2	1	2	2	5	3	4	2	5	4	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:77920009G>T	uc009yva.1	+	9	1838	c.1592G>T	c.(1591-1593)CGG>CTG	p.R531L	USP35_uc001oze.2_Missense_Mutation_p.R287L|USP35_uc001ozc.2_Missense_Mutation_p.R99L|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_Missense_Mutation_p.R142L|USP35_uc001ozf.2_Missense_Mutation_p.R262L	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	531					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CTGCTGGATCGGTAAGGGGGC	0.602													9	77					1.12685e-05	2.88619e-05	1	0	T	77920009	T	T	77920009	3	4	242	1	0	0	0	0	1	0	0	0	17134	1130	39	3	1622	3	USP35	11	77920009	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	18674936	77920009	57086507	178	44549											
PRCP	5547	broad.mit.edu	37	chr11	82571102	82571102	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttttcttccagtatttatCagctactaggtaccgctgat	9	17	6	9	1	2	1	1	1	1	0	3	1	3	1	2	1	3	4	2	1	5	9			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:82571102C>A	uc001ozs.2	-	2	339	c.226G>T	c.(226-228)GAT>TAT	p.D76Y	PRCP_uc001ozr.2_Missense_Mutation_p.D97Y	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	76					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						CAGTATTTATCAGCTACTAGG	0.323													5	35					0.000602214	0.00145337	1	0	A	82571102	A	A	82571102	3	1	242	1	0	0	0	0	1	0	0	0	12511	826	29	2	1296	2	PRCP	11	82571102	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	4651093	82571102	52435414	179	44550											
FAT3	120114	broad.mit.edu	37	chr11	92088407	92088407	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aacctccacactccctatttCccagactttgctgttgttgg	7	14	6	14	0	0	1	0	0	0	1	3	1	3	1	4	1	2	3	4	1	2	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:92088407C>A	uc001pdj.3	+	1	3146	c.3129C>A	c.(3127-3129)TTC>TTA	p.F1043L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1043	Cadherin 9.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTCCCTATTTCCCAGACTTTG	0.507										TCGA Ovarian(4;0.039)			11	48					2.61681e-11	7.69537e-11	1	0	A	92088407	A	A	92088407	3	1	242	1	0	0	0	0	1	0	0	0	5723	854	30	2	3131	2	FAT3	11	92088407	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	9517305	92088407	42918109	180	44551											
MMP20	9313	broad.mit.edu	37	chr11	102477389	102477389	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggcagagtgggcttccccAggaatactttccgaggtcct	7	9	14	11	1	0	1	0	0	0	1	3	3	3	2	4	5	1	2	4	5	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:102477389A>G	uc001phc.2	-	6	843	c.830T>C	c.(829-831)CTG>CCG	p.L277P		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	277					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GGGCTTCCCCAGGAATACTTT	0.532													16	64					0	0	0	0	G	102477389	G	G	102477389	3	3	242	1	0	0	0	0	1	0	0	0	9712	188	7	5	641	5	MMP20	11	102477389	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	10388982	102477389	32529127	181	44552											
SIK2	23235	broad.mit.edu	37	chr11	111593425	111593425	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaaggcccagaacacctgtCagctttattgcaaagaacca	15	7	7	12	0	1	2	1	0	0	2	1	2	1	2	3	1	4	2	3	1	5	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:111593425C>T	uc001plt.2	+	14	2210	c.2092C>T	c.(2092-2094)CAG>TAG	p.Q698*		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	698					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						GAACACCTGTCAGCTTTATTG	0.502													26	71					0	0	0	0	T	111593425	T	T	111593425	4	4	242	1	0	0	0	0	0	1	0	0	14383	827	29	2	2146	2	SIK2	11	111593425	Nonsense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	9116036	111593425	23413091	182	44553											
OR8D1	283159	broad.mit.edu	37	chr11	124180027	124180027	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcataggagacagcaacagcTagggtgggcaccaaggtgtt	12	6	15	8	0	0	1	0	0	0	1	0	2	0	1	1	4	3	5	1	4	4	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:124180027T>C	uc010sag.1	-	1	636	c.636A>G	c.(634-636)CTA>CTG	p.L212L		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		CAGCAACAGCTAGGGTGGGCA	0.507													11	27					0	0	0	0	C	124180027	C	C	124180027	2	2	242	1	0	0	0	0	0	0	0	1	11285	1509	53	5		5	OR8D1	11	124180027	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08	12586602	124180027	10826489	183	44554											
ESAM	90952	broad.mit.edu	37	chr11	124632034	124632034	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaagttggtcaccaggggcCccgggagggaaatcatggcc	9	5	16	11	1	2	0	2	0	0	0	2	2	2	2	4	6	0	2	4	6	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:124632034C>A	uc001qav.3	-	1	190	c.17G>T	c.(16-18)GGG>GTG	p.G6V	ESAM_uc010sao.1_Missense_Mutation_p.G6V|ESAM_uc001qaw.3_RNA|ESAM_uc001qax.3_RNA|ESAM_uc009zbi.2_Missense_Mutation_p.G6V	NM_138961	NP_620411	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule precursor	6					blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction					0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		CACCAGGGGCCCCGGGAGGGA	0.697													5	19					3.59834e-05	9.07009e-05	1	0	A	124632034	A	A	124632034	3	1	242	1	0	0	0	0	1	0	0	0	5271	623	22	4	1183	4	ESAM	11	124632034	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	452007	124632034	10374482	184	44555											
NTM	50863	broad.mit.edu	37	chr11	132016211	132016211	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgggtcacccgggtggcctGgctaaaccgcagcaccatcc	7	5	12	17	3	1	0	1	0	0	0	2	0	2	0	6	4	2	3	6	4	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr11:132016211G>T	uc001qgp.2	+	2	867	c.203G>T	c.(202-204)TGG>TTG	p.W68L	NTM_uc001qgm.2_Missense_Mutation_p.W68L|NTM_uc010sch.1_Missense_Mutation_p.W59L|NTM_uc010sci.1_Missense_Mutation_p.W68L|NTM_uc010scj.1_Missense_Mutation_p.W27L|NTM_uc001qgo.2_Missense_Mutation_p.W68L|NTM_uc001qgq.2_Missense_Mutation_p.W68L	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	68	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						CGGGTGGCCTGGCTAAACCGC	0.577													13	40					7.93312e-07	2.11372e-06	1	0	T	132016211	T	T	132016211	3	4	242	1	0	0	0	0	1	0	0	0	10753	1357	47	4	295	4	NTM	11	132016211	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	7384177	132016211	2990305	185	44556											
LRP6	4040	broad.mit.edu	37	chr12	12334103	12334103	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtgtctgtccaataaagaTttcgtgcaacccagtccaca	12	10	7	12	1	1	1	0	0	1	1	4	1	3	1	3	0	2	1	3	0	4	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:12334103T>C	uc001rah.3	-	6	1389	c.1247A>G	c.(1246-1248)AAT>AGT	p.N416S	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.N416S	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	416	Extracellular (Potential).|LDL-receptor class B 7.|Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CCAATAAAGATTTCGTGCAAC	0.478													13	130					0	0	0	0	C	12334103	C	C	12334103	3	2	242	1	0	0	0	0	1	0	0	0	9012	1493	52	5	3666	5	LRP6	12	12334103	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08		12334103	121517792	186	44557											
GRIN2B	2904	broad.mit.edu	37	chr12	14018732	14018732	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctgcagcccctttttacCttatctgccattatcataga	8	15	4	14	0	2	1	1	0	1	1	3	1	3	1	5	0	4	1	5	0	4	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:14018732C>T	uc001rbt.2	-	2	590	c.411G>A	c.(409-411)AAG>AAA	p.K137K		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	137	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCCTTTTTACCTTATCTGCCA	0.493													123	142					0	0	0	0	T	14018732	T	T	14018732	2	4	242	1	0	0	0	0	0	0	0	1	6819	695	24	4		4	GRIN2B	12	14018732	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	1684629	14018732	119833163	187	44558											
H3F3C	440093	broad.mit.edu	37	chr12	31944920	31944920	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagggcagcttccggatgaGcagctcggtcgacttctgat	8	9	14	10	3	1	2	0	2	1	0	4	5	2	3	1	3	3	4	1	3	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:31944920G>A	uc001rkr.2	-	1	256	c.181C>T	c.(181-183)CTC>TTC	p.L61F		NM_001013699	NP_001013721	Q6NXT2	H3C_HUMAN	histone H3-like	61					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TTCCGGATGAGCAGCTCGGTC	0.602										HNSCC(67;0.2)			32	52					0	0	0	0	A	31944920	A	A	31944920	3	1	242	1	0	0	0	0	1	0	0	0	6974	971	34	4	230	4	H3F3C	12	31944920	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	17926188	31944920	101906975	188	44559											
MLL2	8085	broad.mit.edu	37	chr12	49420184	49420184	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgaggcagcagctgtcCgatggcgtggaacacaaggc	9	6	16	10	2	0	1	0	1	0	0	1	3	1	2	1	5	3	3	1	5	2	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:49420184C>T	uc001rta.3	-	48	15565	c.15565G>A	c.(15565-15567)GGA>AGA	p.G5189R		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5189	FYR N-terminal.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGCAGCTGTCCGATGGCGTGG	0.592			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			6	27					0	0	0	0	T	49420184	T	T	49420184	3	4	242	1	0	0	0	0	1	0	0	0	9674	661	23	1	1076	1	MLL2	12	49420184	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	17475264	49420184	84431711	189	44560											
TROAP	10024	broad.mit.edu	37	chr12	49722998	49722998	+	Frame_Shift_Del	DEL	C	-	-																															aacctaaaacccggttcacaCccatgccatcaacccccaga																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:49722998delC	uc001rtx.3	+	10	1242	c.1075delC	c.(1075-1077)CCCfs	p.P359fs	TROAP_uc009zlh.2_Frame_Shift_Del_p.P359fs|TROAP_uc001rty.2_Frame_Shift_Del_p.P67fs	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	359					cell adhesion	cytoplasm				ovary(1)	1						CCGGTTCACACCCATGCCATC	0.547													---	---	---								-	49722998	-	-	49722998	7	5	242	1	0	1	0	1	0	0	0	0	16642	507	18	0	1211	0	TROAP	12	49722998	Frame_Shift_Del	DEL	C	TCGA-CV-7254-01A-11D-2012-08	302814	49722998	84128897	190	44561											
KRT73	319101	broad.mit.edu	37	chr12	53011886	53011886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcaatgaaggaggcgaacttGttgttcagcaccttgatctg	10	12	11	8	1	3	2	2	2	1	0	3	4	3	3	1	2	2	3	1	2	3	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:53011886G>C	uc001sas.2	-	1	458	c.423C>G	c.(421-423)AAC>AAG	p.N141K		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	141	Coil 1A.|Rod.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGGCGAACTTGTTGTTCAGCA	0.547													33	96					0	0	0	0	C	53011886	C	C	53011886	3	2	242	1	0	0	0	0	1	0	0	0	8525	1368	48	4	1235	4	KRT73	12	53011886	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	3288888	53011886	80840009	191	44562											
ITGA7	3679	broad.mit.edu	37	chr12	56092549	56092549	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccaaagccggaggtcaggcGctccccagacagcataacct	11	4	11	15	2	1	1	1	0	0	1	2	2	2	2	5	3	3	2	5	3	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:56092549G>C	uc001shh.2	-	6	1175	c.955C>G	c.(955-957)CGC>GGC	p.R319G	ITGA7_uc001shg.2_Missense_Mutation_p.R315G|ITGA7_uc010sps.1_Missense_Mutation_p.R222G|ITGA7_uc009znw.2_5'Flank|ITGA7_uc009znx.2_Missense_Mutation_p.R202G	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	359	FG-GAP 5.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						GAGGTCAGGCGCTCCCCAGAC	0.652													8	48					0	0	0	0	C	56092549	C	C	56092549	3	2	242	1	0	0	0	0	1	0	0	0	7920	1087	38	3	2550	3	ITGA7	12	56092549	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	3080663	56092549	77759346	192	44563											
OSBPL8	114882	broad.mit.edu	37	chr12	76791671	76791671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccagctctttagagtacCacgaatctacagaaagataa	15	9	8	9	1	2	3	0	0	2	3	3	4	3	3	2	1	3	2	2	1	6	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:76791671C>T	uc001sye.1	-	8	955	c.475G>A	c.(475-477)GGT>AGT	p.G159S	OSBPL8_uc001syf.1_Missense_Mutation_p.G117S|OSBPL8_uc001syg.1_Missense_Mutation_p.G117S|OSBPL8_uc001syh.1_Missense_Mutation_p.G134S	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	159	PH.				lipid transport		lipid binding			ovary(1)	1						TTTAGAGTACCACGAATCTAC	0.358													9	30					0	0	0	0	T	76791671	T	T	76791671	3	4	242	1	0	0	0	0	1	0	0	0	11337	594	21	4	2262	4	OSBPL8	12	76791671	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	20699122	76791671	57060224	193	44564											
PPFIA2	8499	broad.mit.edu	37	chr12	81719651	81719651	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtctccataaagcctccTgtgaagagaagtaactaagt	14	10	8	9	0	2	2	1	1	1	1	4	3	3	2	3	0	2	1	3	0	6	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:81719651T>A	uc001szo.1	-	22	2710	c.2549_splice	c.e22-1	p.R850_splice	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_Splice_Site|PPFIA2_uc010suh.1_Splice_Site|PPFIA2_uc010sui.1_Splice_Site|PPFIA2_uc010suj.1_Splice_Site|PPFIA2_uc009zsi.1_Splice_Site|PPFIA2_uc010suf.1_Splice_Site|PPFIA2_uc009zsh.2_Splice_Site	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2											ovary(3)|lung(2)|pancreas(1)	6						TAAAGCCTCCTGTGAAGAGAA	0.423													3	25					0	0	0	0	A	81719651	A	A	81719651	5	1	242	1	0	0	0	0	0	0	1	0	12365	1594	55	5	1270	5	PPFIA2	12	81719651	Splice_Site	SNP	T	TCGA-CV-7254-01A-11D-2012-08	4927980	81719651	52132244	194	44565											
TMTC2	160335	broad.mit.edu	37	chr12	83290168	83290168	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cataccctttgttcctgccaCgaacctgtttttctatgtcg	6	16	6	13	2	1	0	0	0	1	0	3	1	2	0	4	0	3	2	4	0	3	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:83290168C>G	uc001szt.2	+	3	1658	c.1226C>G	c.(1225-1227)ACG>AGG	p.T409R	TMTC2_uc001szr.1_Missense_Mutation_p.T409R|TMTC2_uc001szs.1_Missense_Mutation_p.T409R|TMTC2_uc010suk.1_Missense_Mutation_p.T164R	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	409	Helical; (Potential).					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						GTTCCTGCCACGAACCTGTTT	0.418													18	109					0	0	0	0	G	83290168	G	G	83290168	3	3	242	1	0	0	0	0	1	0	0	0	16327	536	19	3	1236	3	TMTC2	12	83290168	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	1570517	83290168	50561727	195	44566											
KERA	11081	broad.mit.edu	37	chr12	91449952	91449952	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacactcgaagtcatgaataGtccaatcatctgaatcatgt	14	11	7	9	1	4	2	3	2	1	0	6	4	5	2	1	0	0	0	1	0	5	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:91449952G>C	uc001tbl.2	-	2	726	c.107C>G	c.(106-108)ACT>AGT	p.T36S		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	36	LRRNT.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						GTCATGAATAGTCCAATCATC	0.408													5	40					0	0	0	0	C	91449952	C	C	91449952	3	2	242	1	0	0	0	0	1	0	0	0	8182	1029	36	4	959	4	KERA	12	91449952	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	8159784	91449952	42401943	196	44567											
ACTR6	64431	broad.mit.edu	37	chr12	100603865	100603865	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaatagctggggctctcagtGcacataggtatttccgagat	11	11	11	8	1	1	1	1	0	1	1	3	2	2	1	1	3	2	4	1	3	4	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:100603865G>T	uc001thb.1	+	5	450	c.394G>T	c.(394-396)GCA>TCA	p.A132S	ACTR6_uc001thc.1_Missense_Mutation_p.A24S|ACTR6_uc001thd.1_Missense_Mutation_p.A132S|ACTR6_uc009ztu.1_Intron|ACTR6_uc001the.1_Missense_Mutation_p.A50S|ACTR6_uc001thf.1_Missense_Mutation_p.A50S|uc001thg.1_Intron	NM_022496	NP_071941	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog	132						cytoplasm|cytoskeleton				ovary(1)	1						GGCTCTCAGTGCACATAGGTA	0.308													8	56					5.18039e-06	1.3486e-05	1	0	T	100603865	T	T	100603865	3	4	242	1	0	0	0	0	1	0	0	0	216	1319	46	4	412	4	ACTR6	12	100603865	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	9153913	100603865	33248030	197	44568											
ALDH1L2	160428	broad.mit.edu	37	chr12	105428104	105428104	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcacaaattcgtcgtggaTggattcttccacgaacaacc	11	11	8	11	3	2	0	1	0	1	0	5	3	3	2	2	2	2	0	2	2	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:105428104T>A	uc001tlc.2	-	19	2345	c.2218A>T	c.(2218-2220)ATC>TTC	p.I740F	ALDH1L2_uc009zuo.2_Missense_Mutation_p.I195F|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	740	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						TCGTCGTGGATGGATTCTTCC	0.418													6	42					0	0	0	0	A	105428104	A	A	105428104	3	1	242	1	0	0	0	0	1	0	0	0	495	1464	51	5	573	5	ALDH1L2	12	105428104	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	4824239	105428104	28423791	198	44569											
RIC8B	55188	broad.mit.edu	37	chr12	107254088	107254088	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggctatgggaatgctgcagGactgttggcggccaggggcc	6	8	18	9	1	0	0	0	0	0	0	0	2	0	2	2	7	2	4	2	7	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:107254088G>T	uc001tlx.2	+	8	1474	c.1349G>T	c.(1348-1350)GGA>GTA	p.G450V	RIC8B_uc001tlw.2_Missense_Mutation_p.G450V|RIC8B_uc001tly.2_Missense_Mutation_p.G410V|RIC8B_uc001tlz.2_RNA|RIC8B_uc009zur.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	450					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						AATGCTGCAGGACTGTTGGCG	0.463													12	41					7.03913e-09	1.95422e-08	1	0	T	107254088	T	T	107254088	3	4	242	1	0	0	0	0	1	0	0	0	13421	1174	41	2	1379	2	RIC8B	12	107254088	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1825984	107254088	26597807	199	44570											
RPH3A	22895	broad.mit.edu	37	chr12	113314582	113314582	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accctattcccaagcatctgCagctgccccccagcctgctg	7	8	7	19	0	1	0	0	0	1	0	2	0	2	0	6	0	6	4	6	0	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:113314582C>A	uc010syl.1	+	13	1444	c.1082C>A	c.(1081-1083)GCA>GAA	p.A361E	RPH3A_uc001ttz.2_Missense_Mutation_p.A361E|RPH3A_uc001tty.2_Missense_Mutation_p.A357E|RPH3A_uc009zwe.1_Missense_Mutation_p.A357E|RPH3A_uc010sym.1_Missense_Mutation_p.A312E|RPH3A_uc001tua.2_Missense_Mutation_p.A121E	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	361	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		CAAGCATCTGCAGCTGCCCCC	0.642													8	49					0.000274275	0.000672143	1	0	A	113314582	A	A	113314582	3	1	242	1	0	0	0	0	1	0	0	0	13616	710	25	4	1124	4	RPH3A	12	113314582	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	6060494	113314582	20537313	200	44571											
IQCD	115811	broad.mit.edu	37	chr12	113645284	113645284	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctctccgccaattccttttCaagagtatcaatgatttgtt	9	17	5	10	1	3	2	2	1	1	1	6	2	5	2	3	0	0	2	3	0	4	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:113645284C>T	uc001tuv.1	-	2	1110	c.688G>A	c.(688-690)GAA>AAA	p.E230K	IQCD_uc001tuu.2_Missense_Mutation_p.E230K	NM_138451	NP_612460	Q96DY2	IQCD_HUMAN	IQ motif containing D	230										ovary(1)	1						AATTCCTTTTCAAGAGTATCA	0.383													5	56					0	0	0	0	T	113645284	T	T	113645284	3	4	242	1	0	0	0	0	1	0	0	0	7844	835	29	2	363	2	IQCD	12	113645284	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	330702	113645284	20206611	201	44572											
TMEM132B	114795	broad.mit.edu	37	chr12	126135284	126135284	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagaagggacgaggctgcTccctgcagtaccagcacgcc	11	4	13	13	2	0	2	0	0	0	2	1	4	1	3	3	2	4	5	3	2	3	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:126135284T>C	uc001uhe.1	+	7	1692	c.1684T>C	c.(1684-1686)TCC>CCC	p.S562P	TMEM132B_uc001uhf.1_Missense_Mutation_p.S74P	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	562	Extracellular (Potential).					integral to membrane		p.S562S(1)		skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		ACGAGGCTGCTCCCTGCAGTA	0.572													11	42					0	0	0	0	C	126135284	C	C	126135284	3	2	242	1	0	0	0	0	1	0	0	0	16112	1551	54	5	1710	5	TMEM132B	12	126135284	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	12490000	126135284	7716611	202	44573											
PIWIL1	9271	broad.mit.edu	37	chr12	130827590	130827590	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgccaccagcagagggggAattatttggccgtggacggc	8	6	16	11	3	0	1	0	0	0	1	0	3	0	3	4	5	1	1	4	5	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr12:130827590A>T	uc001uik.2	+	3	224	c.134A>T	c.(133-135)GAA>GTA	p.E45V	PIWIL1_uc001uij.1_Missense_Mutation_p.E45V	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	45					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GCAGAGGGGGAATTATTTGGC	0.473													6	31					0	0	0	0	T	130827590	T	T	130827590	3	4	242	1	0	0	0	0	1	0	0	0	12012	246	9	5	140	5	PIWIL1	12	130827590	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	4692306	130827590	3024305	203	44574											
FRY	10129	broad.mit.edu	37	chr13	32812117	32812117	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatggtggatgcatcccacGctattggtaaagccagcctc	9	9	10	13	1	0	0	0	0	0	0	2	1	1	1	4	3	3	3	4	3	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr13:32812117G>T	uc001utx.2	+	44	6908	c.6412G>T	c.(6412-6414)GCT>TCT	p.A2138S	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TGCATCCCACGCTATTGGTAA	0.458													16	74					6.94344e-10	1.9975e-09	1	0	T	32812117	T	T	32812117	3	4	242	1	0	0	0	0	1	0	0	0	6097	1087	38	3	6586	3	FRY	13	32812117	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08		32812117	82357761	204	44575											
STARD13	90627	broad.mit.edu	37	chr13	33701605	33701605	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaggctcagctggctggcCgtctggctgctgatgtgggg	4	9	18	10	1	2	1	1	1	1	0	2	1	2	1	1	6	3	6	1	6	0	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr13:33701605C>G	uc001uuw.2	-	6	1953	c.1827G>C	c.(1825-1827)ACG>ACC	p.T609T	STARD13_uc001uuu.2_Silent_p.T601T|STARD13_uc001uuv.2_Silent_p.T491T|STARD13_uc001uux.2_Silent_p.T574T|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Silent_p.T594T	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	609					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GCTGGCTGGCCGTCTGGCTGC	0.632													8	8					0	0	0	0	G	33701605	G	G	33701605	2	3	242	1	0	0	0	0	0	0	0	1	15322	639	23	3		3	STARD13	13	33701605	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	889488	33701605	81468273	205	44576											
FREM2	341640	broad.mit.edu	37	chr13	39343779	39343793	+	In_Frame_Del	DEL	AGTGCAGTTCAACCC	-	-																															aagggcaaagcacagaaacaAgtgcagttcaacccaggcca																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr13:39343779_39343793delAGTGCAGTTCAACCC	uc001uwv.2	+	4	5784_5798	c.5475_5489delAGTGCAGTTCAACCC	c.(5473-5490)CAAGTGCAGTTCAACCCA>CAA	p.VQFNP1826del	FREM2_uc001uww.2_5'UTR	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1826_1830	Calx-beta 1.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CACAGAAACAAGTGCAGTTCAACCCAGGCCAGACC	0.479													---	---	---								-	39343793	-	-	39343779	7	5	242	1	0	1	0	1	0	0	0	0	6079	69	3	0	5489	0	FREM2	13	39343779	In_Frame_Del	DEL	AGTGCAGTTCAACCC	TCGA-CV-7254-01A-11D-2012-08	5642174	39343779	75826099	206	44577											
FREM2	341640	broad.mit.edu	37	chr13	39435695	39435695	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actgtcacaatgccacacatAgatggtaggtgacttgggta	12	10	11	8	0	1	2	1	1	0	1	1	2	1	2	1	3	1	2	1	3	4	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr13:39435695A>T	uc001uwv.2	+	15	7956	c.7647A>T	c.(7645-7647)ATA>ATT	p.I2549I	FREM2_uc001uww.2_Silent_p.I635I	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2549	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGCCACACATAGATGGTAGGT	0.423													21	67					0	0	0	0	T	39435695	T	T	39435695	2	4	242	1	0	0	0	0	0	0	0	1	6079	410	15	5		5	FREM2	13	39435695	Silent	SNP	A	TCGA-CV-7254-01A-11D-2012-08	91916	39435695	75734183	207	44578											
LCP1	3936	broad.mit.edu	37	chr13	46726918	46726918	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgggacttgctcttaccttCatttctgctgagttcaatgt	6	18	8	9	0	4	1	2	1	2	0	4	2	4	2	1	1	3	3	1	1	2	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr13:46726918C>T	uc001vaz.3	-	7	862	c.736G>A	c.(736-738)GAA>AAA	p.E246K	LCP1_uc001vba.3_Missense_Mutation_p.E246K	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	246	Actin-binding 1.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		CTCTTACCTTCATTTCTGCTG	0.458			T	BCL6	NHL 								9	34					0	0	0	0	T	46726918	T	T	46726918	3	4	242	1	0	0	0	0	1	0	0	0	8731	835	29	2	1187	2	LCP1	13	46726918	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	7291223	46726918	68442960	208	44579											
OR4N2	390429	broad.mit.edu	37	chr14	20295661	20295661	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcatcctccttggtctgacCcagtctcaagatattcagct	8	14	6	13	0	4	2	3	1	2	1	7	2	6	2	3	1	1	1	3	1	2	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr14:20295661C>A	uc010tkv.1	+	1	54	c.54C>A	c.(52-54)ACC>ACA	p.T18T		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTGGTCTGACCCAGTCTCAAG	0.383													20	136					8.34094e-07	2.21495e-06	1	0	A	20295661	A	A	20295661	2	1	242	1	0	0	0	0	0	0	0	1	11131	610	22	4		4	OR4N2	14	20295661	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08		20295661	87053879	209	44580											
SLC7A8	23428	broad.mit.edu	37	chr14	23609700	23609700	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtagggatcaacaagctcCtcagtcacgtaattcagaaa	14	10	8	9	1	4	1	4	0	0	1	5	2	5	2	1	1	2	3	1	1	5	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr14:23609700C>T	uc001wiz.2	-	5	1494	c.768G>A	c.(766-768)GAG>GAA	p.E256E	SLC7A8_uc001wix.2_Silent_p.E53E|SLC7A8_uc010tnk.1_Intron|SLC7A8_uc010tnl.1_Silent_p.E151E|SLC7A8_uc001wiy.2_RNA|SLC7A8_uc010akj.2_Silent_p.E256E	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	256					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	CAACAAGCTCCTCAGTCACGT	0.532													22	146					0	0	0	0	T	23609700	T	T	23609700	2	4	242	1	0	0	0	0	0	0	0	1	14768	680	24	4		4	SLC7A8	14	23609700	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	3314039	23609700	83739840	210	44581											
DHRS2	10202	broad.mit.edu	37	chr14	24108495	24108495	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggccaagctgcagggggAggggctgagtgtggcgggca	7	5	21	8	1	0	1	0	1	0	0	0	2	0	2	1	7	2	4	1	7	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr14:24108495A>G	uc001wkt.3	+	3	695	c.248A>G	c.(247-249)GAG>GGG	p.E83G	DHRS2_uc010aku.1_Missense_Mutation_p.E83G|DHRS2_uc001wku.3_Missense_Mutation_p.E83G|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Missense_Mutation_p.E83G	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	61					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		CTGCAGGGGGAGGGGCTGAGT	0.687													3	90					0	0	0	0	G	24108495	G	G	24108495	3	3	242	1	0	0	0	0	1	0	0	0	4512	304	11	5	254	5	DHRS2	14	24108495	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	498795	24108495	83241045	211	44582											
PRKD1	5587	broad.mit.edu	37	chr14	30103722	30103722	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agactgcactaccctcatgaGtgggatattgttgcttgttg	8	14	11	8	0	1	2	1	1	0	1	1	3	1	3	1	1	3	4	1	1	2	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr14:30103722G>T	uc001wqh.2	-	8	1397	c.1216C>A	c.(1216-1218)CTC>ATC	p.L406I		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	406					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		ACCCTCATGAGTGGGATATTG	0.403													25	140					6.32553e-13	1.88815e-12	1	0	T	30103722	T	T	30103722	3	4	242	1	0	0	0	0	1	0	0	0	12580	1029	36	4	1566	4	PRKD1	14	30103722	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	5995227	30103722	77245818	212	44583											
INSM2	84684	broad.mit.edu	37	chr14	36003680	36003680	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcggcccgggaacagtcgggGtcgccatgtcgggcggctgg	4	5	20	12	6	0	0	0	0	0	0	3	1	0	1	2	7	1	1	2	7	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr14:36003680G>T	uc001wth.1	+	1	433	c.222G>T	c.(220-222)GGG>GGT	p.G74G		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		AACAGTCGGGGTCGCCATGTC	0.726													9	4					0.000442599	0.00107799	1	0	T	36003680	T	T	36003680	2	4	242	1	0	0	0	0	0	0	0	1	7811	1248	44	4		4	INSM2	14	36003680	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	5899958	36003680	71345860	213	44584											
SLC25A21	89874	broad.mit.edu	37	chr14	37283178	37283178	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caagcttttataactgtttgGatcggttgcacatctctgaa	10	15	8	8	1	1	1	0	1	1	0	3	2	1	2	0	2	3	4	0	2	4	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr14:37283178G>T	uc001wtz.1	-	3	458	c.148C>A	c.(148-150)CCA>ACA	p.P50T		NM_030631	NP_085134	Q9BQT8	ODC_HUMAN	solute carrier family 25 (mitochondrial	50	Solcar 1.				lysine catabolic process	integral to membrane|mitochondrial inner membrane	alpha-ketoglutarate transmembrane transporter activity|binding			skin(1)	1	Esophageal squamous(585;0.164)|Breast(36;0.179)|Hepatocellular(127;0.213)		Lung(8;2.16e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.0112)|all cancers(34;0.0274)|LUSC - Lung squamous cell carcinoma(13;0.149)	GBM - Glioblastoma multiforme(112;0.00204)		TAACTGTTTGGATCGGTTGCA	0.313													8	58					0.000274275	0.000672143	1	0	T	37283178	T	T	37283178	3	4	242	1	0	0	0	0	1	0	0	0	14548	1174	41	2	788	2	SLC25A21	14	37283178	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1279498	37283178	70066362	214	44585											
C14orf142	84520	broad.mit.edu	37	chr14	93673339	93673339	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaggacacccgcagcttcTgcggcttcccttcctgcccg	5	8	9	19	3	1	0	0	0	1	0	3	1	3	1	4	2	3	3	4	2	0	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr14:93673339T>A	uc001ybl.1	-	1	121	c.44A>T	c.(43-45)CAG>CTG	p.Q15L	UBR7_uc001ybm.3_5'Flank|UBR7_uc001ybn.3_5'Flank|UBR7_uc010auq.2_5'Flank	NM_032490	NP_115879	Q9BXV9	CN142_HUMAN	hypothetical protein LOC84520	15											0		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.177)|all cancers(159;0.198)|COAD - Colon adenocarcinoma(157;0.203)		CCGCAGCTTCTGCGGCTTCCC	0.622											OREG0022885	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	61					0	0	0	0	A	93673339	A	A	93673339	3	1	242	1	0	0	0	0	1	0	0	0	1753	1580	55	5	266	5	C14orf142	14	93673339	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	56390161	93673339	13676201	215	44586											
AK7	122481	broad.mit.edu	37	chr14	96937852	96937852	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatataattagatttatgaaAgaaaagctaaaatcaatgcc	20	12	5	4	0	1	3	1	1	0	2	1	3	1	3	1	0	2	1	1	0	11	7			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr14:96937852A>G	uc001yfn.2	+	13	1439	c.1395A>G	c.(1393-1395)AAA>AAG	p.K465K		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	465	Adenylate kinase.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GATTTATGAAAGAAAAGCTAA	0.294													4	32					0	0	0	0	G	96937852	G	G	96937852	2	3	242	1	0	0	0	0	0	0	0	1	444	69	3	5		5	AK7	14	96937852	Silent	SNP	A	TCGA-CV-7254-01A-11D-2012-08	3264513	96937852	10411688	216	44587											
RYR3	6263	broad.mit.edu	37	chr15	33944987	33944987	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagttcccagagatcaaatcGgagcaacgtggacctggaga	13	6	12	10	2	1	2	1	0	0	2	3	6	2	4	2	3	2	2	2	3	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:33944987G>A	uc001zhi.2	+	32	4281	c.4211G>A	c.(4210-4212)CGG>CAG	p.R1404Q	RYR3_uc010bar.2_Missense_Mutation_p.R1404Q	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1404	4 X approximate repeats.|B30.2/SPRY 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGATCAAATCGGAGCAACGTG	0.537													11	50					0	0	0	0	A	33944987	A	A	33944987	3	1	242	1	0	0	0	0	1	0	0	0	13835	1116	39	1	4337	1	RYR3	15	33944987	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08		33944987	68586405	217	44588											
UNC13C	440279	broad.mit.edu	37	chr15	54306702	54306702	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgcagatgcaacacctctCtggcactcacagagtgattt	11	11	8	11	0	2	3	1	1	1	2	3	3	2	3	1	1	3	3	1	1	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:54306702C>T	uc002ack.2	+	1	1602	c.1602C>T	c.(1600-1602)CTC>CTT	p.L534L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	534					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CAACACCTCTCTGGCACTCAC	0.358													7	61					0	0	0	0	T	54306702	T	T	54306702	2	4	242	1	0	0	0	0	0	0	0	1	17054	900	32	2		2	UNC13C	15	54306702	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	20361715	54306702	48224690	218	44589											
PYGO1	26108	broad.mit.edu	37	chr15	55838897	55838897	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgccaaatcggggttagaaActtggctagcattctgtgga	11	11	12	7	1	1	1	0	0	1	1	2	2	1	2	1	4	3	3	1	4	4	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:55838897A>T	uc010bfl.1	-	3	640	c.584T>A	c.(583-585)GTT>GAT	p.V195D	PYGO1_uc002adf.1_Missense_Mutation_p.V195D	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	195	Asn-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		GGGGTTAGAAACTTGGCTAGC	0.348													23	48					0	0	0	0	T	55838897	T	T	55838897	3	4	242	1	0	0	0	0	1	0	0	0	12928	43	2	5	679	5	PYGO1	15	55838897	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	1532195	55838897	46692495	219	44590											
LIPC	3990	broad.mit.edu	37	chr15	58724316	58724316	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccttggacaaagcctgaaaCcaggtaagagcctgactttt	12	9	9	11	0	0	3	0	2	0	1	0	4	0	4	4	2	3	1	4	2	3	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:58724316C>G	uc010bga.1	+	3	693	c.85C>G	c.(85-87)CCA>GCA	p.P29A	LIPC_uc010bfz.1_Missense_Mutation_p.P29A|LIPC_uc002afa.1_Missense_Mutation_p.P29A|LIPC_uc010bgb.1_5'UTR|LIPC_uc010ugy.1_Missense_Mutation_p.P29A	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	29					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		AAGCCTGAAACCAGGTAAGAG	0.448													16	76					0	0	0	0	G	58724316	G	G	58724316	3	3	242	1	0	0	0	0	1	0	0	0	8862	507	18	4	87	4	LIPC	15	58724316	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	2885419	58724316	43807076	220	44591											
CILP	8483	broad.mit.edu	37	chr15	65491007	65491007	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcagcctgtccacaaatgtGagcaccagcctctcagtgtc	9	9	9	14	0	1	1	1	1	1	0	4	1	2	1	4	0	4	2	4	0	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:65491007G>C	uc002aon.2	-	9	1798	c.1617C>G	c.(1615-1617)CTC>CTG	p.L539L		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	539					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CCACAAATGTGAGCACCAGCC	0.522													14	65					0	0	0	0	C	65491007	C	C	65491007	2	2	242	1	0	0	0	0	0	0	0	1	3444	1277	45	2		2	CILP	15	65491007	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	6766691	65491007	37040385	221	44592											
CYP11A1	1583	broad.mit.edu	37	chr15	74636273	74636273	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcaatgaatcgctgggccTcggggttcactacttcctcc	7	11	9	14	2	2	1	2	1	0	0	6	1	4	1	3	3	1	2	3	3	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:74636273T>C	uc002axt.2	-	4	841	c.686A>G	c.(685-687)GAG>GGG	p.E229G	CYP11A1_uc002axs.2_Missense_Mutation_p.E71G|CYP11A1_uc010bjm.1_Missense_Mutation_p.E71G|CYP11A1_uc010bjn.1_Intron|CYP11A1_uc010bjo.1_Missense_Mutation_p.E229G|CYP11A1_uc010bjp.1_RNA|CYP11A1_uc010ulj.1_Missense_Mutation_p.E9G	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	229					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	TCGCTGGGCCTCGGGGTTCAC	0.572													3	138					0	0	0	0	C	74636273	C	C	74636273	3	2	242	1	0	0	0	0	1	0	0	0	4161	1551	54	5	903	5	CYP11A1	15	74636273	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	9145266	74636273	27895119	222	44593											
RASGRF1	5923	broad.mit.edu	37	chr15	79382664	79382664	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaagccccgagggccgcgaGctcgagtcgctctcgaagta	9	6	13	13	6	1	0	0	0	1	0	4	4	1	0	3	1	2	3	3	1	4	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:79382664G>A	uc002beq.2	-	1	552	c.177C>T	c.(175-177)AGC>AGT	p.S59S	RASGRF1_uc002bep.2_Silent_p.S59S|RASGRF1_uc002ber.3_Silent_p.S59S	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	59	PH 1.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						AGGGCCGCGAGCTCGAGTCGC	0.637													8	102					0	0	0	0	A	79382664	A	A	79382664	2	1	242	1	0	0	0	0	0	0	0	1	13137	962	34	4		4	RASGRF1	15	79382664	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	4746391	79382664	23148728	223	44594											
AGBL1	123624	broad.mit.edu	37	chr15	86940669	86940669	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgccagttgggtgatgaaggGtaccttggagttcctggtca	7	12	15	7	0	1	2	1	2	0	0	2	3	2	3	3	4	2	3	3	4	2	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:86940669G>T	uc002blz.1	+	17	2389	c.2309G>T	c.(2308-2310)GGT>GTT	p.G770V		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	770					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GTGATGAAGGGTACCTTGGAG	0.483													21	73					4.35082e-09	1.24264e-08	1	0	T	86940669	T	T	86940669	3	4	242	1	0	0	0	0	1	0	0	0	375	1261	44	4	2371	4	AGBL1	15	86940669	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	7558005	86940669	15590723	224	44595											
NTRK3	4916	broad.mit.edu	37	chr15	88472442	88472442	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgtaataatccgtgctgtAgacatctctggacatgccga	10	11	9	11	2	1	1	0	0	1	1	3	3	2	2	3	1	2	3	3	1	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:88472442A>T	uc002bme.1	-	16	2275	c.2113T>A	c.(2113-2115)TAC>AAC	p.Y705N	NTRK3_uc002bmh.2_Missense_Mutation_p.Y697N|NTRK3_uc002bmf.1_Missense_Mutation_p.Y705N|NTRK3_uc010upl.1_Missense_Mutation_p.Y607N|NTRK3_uc010bnh.1_Missense_Mutation_p.Y697N	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	705	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCCGTGCTGTAGACATCTCTG	0.517			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			29	126					0	0	0	0	T	88472442	T	T	88472442	3	4	242	1	0	0	0	0	1	0	0	0	10762	420	15	5	422	5	NTRK3	15	88472442	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	1531773	88472442	14058950	225	44596											
BLM	641	broad.mit.edu	37	chr15	91304239	91304239	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caataaatgacttagaaagaGaaacccaaccttcctatgat	18	9	5	9	0	0	4	0	2	0	2	1	5	1	4	3	0	2	0	3	0	8	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:91304239G>C	uc002bpr.2	+	7	1733	c.1636G>C	c.(1636-1638)GAA>CAA	p.E546Q	BLM_uc010uqh.1_Missense_Mutation_p.E546Q|BLM_uc010uqi.1_Missense_Mutation_p.E171Q|BLM_uc010bnx.2_Missense_Mutation_p.E546Q|BLM_uc002bps.1_Missense_Mutation_p.E108Q	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	546					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			CTTAGAAAGAGAAACCCAACC	0.338			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				6	72					0	0	0	0	C	91304239	C	C	91304239	3	2	242	1	0	0	0	0	1	0	0	0	1448	943	33	2	1658	2	BLM	15	91304239	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	2831797	91304239	11227153	226	44597											
CHD2	1106	broad.mit.edu	37	chr15	93540258	93540258	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggttaatgtgaaatccattAtccaacatgaagaggagttt	15	12	9	5	0	0	3	0	2	0	1	2	4	2	4	2	2	1	2	2	2	5	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr15:93540258A>G	uc002bsp.2	+	29	4242	c.3667A>G	c.(3667-3669)ATC>GTC	p.I1223V	CHD2_uc002bso.1_Missense_Mutation_p.I1223V	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1223					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GAAATCCATTATCCAACATGA	0.378													3	36					0	0	0	0	G	93540258	G	G	93540258	3	3	242	1	0	0	0	0	1	0	0	0	3340	449	16	5	3781	5	CHD2	15	93540258	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	2236019	93540258	8991134	227	44598											
WDR90	197335	broad.mit.edu	37	chr16	703573	703573	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcactattggcctcggccCaggcaagggcccctagtgtg	6	8	13	14	1	1	0	1	0	0	0	2	0	1	0	4	4	0	2	4	4	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr16:703573C>A	uc002cii.1	+	12	1336	c.1282C>A	c.(1282-1284)CAG>AAG	p.Q428K	WDR90_uc002cig.1_Missense_Mutation_p.Q428K|WDR90_uc002cih.1_Missense_Mutation_p.Q429K|WDR90_uc002cij.1_RNA|WDR90_uc002cik.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	428	WD 1.									ovary(1)	1		Hepatocellular(780;0.0218)				GGCCTCGGCCCAGGCAAGGGC	0.652													19	71					1.56452e-12	4.65255e-12	1	0	A	703573	A	A	703573	3	1	242	1	0	0	0	0	1	0	0	0	17405	595	21	4	1328	4	WDR90	16	703573	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08		703573	89651180	228	44599											
WDR90	197335	broad.mit.edu	37	chr16	715788	715788	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcttgtgatccagttccAggtgctgaaccaggtgtgtg	7	11	15	8	0	0	2	0	2	0	0	2	3	2	3	3	3	3	3	3	3	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr16:715788A>G	uc002cii.1	+	35	4475	c.4421A>G	c.(4420-4422)CAG>CGG	p.Q1474R	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Missense_Mutation_p.Q89R|WDR90_uc010uul.1_Missense_Mutation_p.Q73R|WDR90_uc002cio.1_Missense_Mutation_p.Q73R|WDR90_uc010bqx.1_Missense_Mutation_p.Q73R|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1474										ovary(1)	1		Hepatocellular(780;0.0218)				ATCCAGTTCCAGGTGCTGAAC	0.701													3	29					0	0	0	0	G	715788	G	G	715788	3	3	242	1	0	0	0	0	1	0	0	0	17405	188	7	5	4559	5	WDR90	16	715788	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	12215	715788	89638965	229	44600											
NTN3	4917	broad.mit.edu	37	chr16	2522435	2522435	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgtcgtcccttactcctacGcagccaccgacctccaggtg	6	8	8	19	4	0	0	0	0	0	0	4	1	3	0	7	1	3	1	7	1	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr16:2522435G>C	uc002cqj.2	+	1	936	c.733G>C	c.(733-735)GCA>CCA	p.A245P	TBC1D24_uc002cqk.2_5'Flank|TBC1D24_uc002cql.2_5'Flank	NM_006181	NP_006172	O00634	NET3_HUMAN	netrin 3 precursor	245	Laminin N-terminal.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				central_nervous_system(1)	1						TTACTCCTACGCAGCCACCGA	0.652													8	57					0	0	0	0	C	2522435	C	C	2522435	3	2	242	1	0	0	0	0	1	0	0	0	10755	1087	38	3	735	3	NTN3	16	2522435	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1806647	2522435	87832318	230	44601											
RNF40	9810	broad.mit.edu	37	chr16	30776589	30776589	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggacttgcagtgggacatcGagaagctgcggaagcgagag	12	5	17	7	3	0	2	0	0	0	2	1	7	0	5	0	3	4	2	0	3	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr16:30776589G>A	uc002dzq.2	+	7	982	c.859G>A	c.(859-861)GAG>AAG	p.E287K	RNF40_uc010caa.2_Missense_Mutation_p.E287K|RNF40_uc010cab.2_Missense_Mutation_p.E287K|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Missense_Mutation_p.E287K|RNF40_uc010vfb.1_Intron|RNF40_uc010vfc.1_5'Flank	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	287	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			GTGGGACATCGAGAAGCTGCG	0.582													10	66					0	0	0	0	A	30776589	A	A	30776589	3	1	242	1	0	0	0	0	1	0	0	0	13558	1059	37	1	881	1	RNF40	16	30776589	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	28254154	30776589	59578164	231	44602											
NUP93	9688	broad.mit.edu	37	chr16	56865903	56865903	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggcggacaaaactgaggAttacctgtggctgaaggtag	12	8	15	6	1	0	2	0	2	0	0	0	4	0	4	1	5	2	2	1	5	5	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr16:56865903A>T	uc002eka.2	+	11	1356	c.1235A>T	c.(1234-1236)GAT>GTT	p.D412V	NUP93_uc002ekb.2_Missense_Mutation_p.D289V|NUP93_uc010vhi.1_Missense_Mutation_p.D289V	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	412					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						AAAACTGAGGATTACCTGTGG	0.502													17	94					0	0	0	0	T	56865903	T	T	56865903	3	4	242	1	0	0	0	0	1	0	0	0	10826	333	12	5	1273	5	NUP93	16	56865903	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	26089314	56865903	33488850	232	44603											
CES2	8824	broad.mit.edu	37	chr16	66969362	66969362	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctatgactgctcagtccCgctctcctaccacacccacc	8	8	4	21	1	2	1	1	1	1	0	4	1	3	1	6	0	2	2	6	0	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr16:66969362C>G	uc002eqr.2	+	1	1016	c.16C>G	c.(16-18)CGC>GGC	p.R6G	CES2_uc002eqq.2_Missense_Mutation_p.R6G|CES2_uc002eqs.2_5'UTR|FAM96B_uc002eqp.2_5'Flank	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	Error:Variant_position_missing_in_O00748_after_alignment					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		TGCTCAGTCCCGCTCTCCTAC	0.647													11	129					0	0	0	0	G	66969362	G	G	66969362	3	3	242	1	0	0	0	0	1	0	0	0	3285	652	23	3	18	3	CES2	16	66969362	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	10103459	66969362	23385391	233	44604											
TPPP3	51673	broad.mit.edu	37	chr16	67425061	67425061	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catctcccagccaatctgccCttcccctcccccaagcccag	7	7	4	23	0	2	0	0	0	2	0	5	0	4	0	8	0	3	0	8	0	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr16:67425061C>A	uc002esz.2	-	1	789	c.-46G>T	c.(-48--44)AAGGG>AATGG		TPPP3_uc002eta.2_Intron|TPPP3_uc002etb.2_Intron	NM_016140	NP_057224	Q9BW30	TPPP3_HUMAN	tubulin polymerization-promoting protein family						microtubule bundle formation	cytoplasm|microtubule	calcium ion binding|tubulin binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0336)|Epithelial(162;0.0781)		CCAATCTGCCCTTCCCCTCCC	0.607													10	18					1.58986e-06	4.17997e-06	1	0	A	67425061	A	A	67425061	1	1	242	1	0	0	0	0	0	0	0	0	16482	696	24	4		4	TPPP3	16	67425061	Translation_Start_Site	SNP	C	TCGA-CV-7254-01A-11D-2012-08	455699	67425061	22929692	234	44605											
ZFHX3	463	broad.mit.edu	37	chr16	72984464	72984464	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtcacaggcgttgcacttGaggtgcacggggttgccgat	7	10	15	9	3	1	1	1	1	0	0	1	2	1	1	1	4	3	4	1	4	1	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr16:72984464G>C	uc002fck.2	-	3	3793	c.3120C>G	c.(3118-3120)CTC>CTG	p.L1040L	ZFHX3_uc002fcl.2_Silent_p.L126L	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1040	C2H2-type 8; atypical.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CGTTGCACTTGAGGTGCACGG	0.597													24	33					0	0	0	0	C	72984464	C	C	72984464	2	2	242	1	0	0	0	0	0	0	0	1	17701	1277	45	2		2	ZFHX3	16	72984464	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	5559403	72984464	17370289	235	44606											
BCMO1	53630	broad.mit.edu	37	chr16	81298334	81298334	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctaaacatgggcacatcCattgtggaaaaggggaagac	14	8	12	7	0	1	1	0	0	1	1	2	3	2	3	1	4	1	2	1	4	5	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr16:81298334C>T	uc002fgn.1	+	5	779	c.561C>T	c.(559-561)TCC>TCT	p.S187S	BCMO1_uc010vnp.1_Silent_p.S118S	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	187					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						TGGGCACATCCATTGTGGAAA	0.428													10	38					0	0	0	0	T	81298334	T	T	81298334	2	4	242	1	0	0	0	0	0	0	0	1	1386	581	21	4		4	BCMO1	16	81298334	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	8313870	81298334	9056419	236	44607											
SPATA2L	124044	broad.mit.edu	37	chr16	89764695	89764695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacccttcagcacgtgcaCgtagcccccagagaaggtct	10	6	9	16	2	2	1	1	0	1	1	2	2	2	1	3	1	3	3	3	1	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr16:89764695C>T	uc002foj.2	-	3	387	c.322G>A	c.(322-324)GTG>ATG	p.V108M	SPATA2L_uc002fok.2_Missense_Mutation_p.V108M	NM_152339	NP_689552	Q8IUW3	SPA2L_HUMAN	spermatogenesis associated 2-like	108											0		Lung NSC(15;0.00043)|all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		AGCACGTGCACGTAGCCCCCA	0.617													25	252					0	0	0	0	T	89764695	T	T	89764695	3	4	242	1	0	0	0	0	1	0	0	0	15075	536	19	1	956	1	SPATA2L	16	89764695	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	8466361	89764695	590058	237	44608											
RILP	83547	broad.mit.edu	37	chr17	1552568	1552570	+	In_Frame_Del	DEL	CCT	-	-																															gtcccgctgtcggtccgtgaCctccttgagctgccgcagca																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:1552568_1552570delCCT	uc002ftd.2	-	3	647_649	c.353_355delAGG	c.(352-357)GAGGTC>GTC	p.E118del		NM_031430	NP_113618	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	118	Potential.				endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CGGTCCGTGACCTCCTTGAGCTG	0.542													---	---	---								-	1552570	-	-	1552568	7	5	242	1	0	1	0	1	0	0	0	0	13425	507	18	0	874	0	RILP	17	1552568	In_Frame_Del	DEL	CCT	TCGA-CV-7254-01A-11D-2012-08		1552568	79642642	238	44609											
KIF1C	10749	broad.mit.edu	37	chr17	4910344	4910344	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcccccaacacggagtccCagattgggcctgaggaagcc	9	6	11	15	1	1	2	0	1	1	1	3	4	2	4	5	3	2	0	5	3	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:4910344C>A	uc002gan.1	+	14	1626	c.1300C>A	c.(1300-1302)CAG>AAG	p.Q434K		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	434					microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						CACGGAGTCCCAGATTGGGCC	0.597													17	64					0.000566183	0.00137477	1	0	A	4910344	A	A	4910344	3	1	242	1	0	0	0	0	1	0	0	0	8324	595	21	4	1346	4	KIF1C	17	4910344	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	3357776	4910344	76284866	239	44610											
RPAIN	84268	broad.mit.edu	37	chr17	5323591	5323592	+	Missense_Mutation	DNP	TG	CT	CT																															aactggtgggctcgccgcctTggaaagaggctttccggcag																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:5323591_5323592TG>CT	uc002gbq.2	+	1	631_632	c.61_62TG>CT	c.(61-63)TGG>CTG	p.W21L	NUP88_uc002gbo.1_5'Flank|NUP88_uc010vsx.1_5'Flank|NUP88_uc010cle.1_5'Flank|NUP88_uc010vsy.1_5'Flank|RPAIN_uc010vsz.1_Missense_Mutation_p.W21L|RPAIN_uc002gbp.1_Missense_Mutation_p.L74S|RPAIN_uc010vta.1_Missense_Mutation_p.W21L|RPAIN_uc010vtb.1_Missense_Mutation_p.W21L|RPAIN_uc002gbs.2_Missense_Mutation_p.L74S|RPAIN_uc002gbt.2_Missense_Mutation_p.W21L|RPAIN_uc002gbu.2_Missense_Mutation_p.L74S|RPAIN_uc002gbv.2_RNA|RPAIN_uc002gbr.2_RNA|RPAIN_uc002gbw.2_Missense_Mutation_p.W21L	NM_001033002	NP_001028174	Q86UA6	RIP_HUMAN	RPA interacting protein isoform b	21					DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|cytoplasm|nucleolus|PML body|PML body	metal ion binding|protein complex binding				0						CTCGCCGCCTTGGAAAGAGGCT	0.624													12	35					0	0	0	0	CT	5323592	CT	CT	5323591	3	2	242	1	0	0	0	0	1	0	0	0	13605	1812	63	5	63	5	RPAIN	17	5323591	Missense_Mutation	DNP	TG	TCGA-CV-7254-01A-11D-2012-08	413247	5323591	75871619	240	44611											
TP53	7157	broad.mit.edu	37	chr17	7577508	7577508	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctcctgacctggagtctTccagtgtgatgatggtgagg	6	12	15	8	0	1	4	0	4	1	0	3	5	3	5	3	4	0	1	3	4	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:7577508T>G	uc002gim.2	-	7	967	c.773A>C	c.(772-774)GAA>GCA	p.E258A	TP53_uc002gig.1_Missense_Mutation_p.E258A|TP53_uc002gih.2_Missense_Mutation_p.E258A|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E126A|TP53_uc010cng.1_Missense_Mutation_p.E126A|TP53_uc002gii.1_Missense_Mutation_p.E126A|TP53_uc010cnh.1_Missense_Mutation_p.E258A|TP53_uc010cni.1_Missense_Mutation_p.E258A|TP53_uc002gij.2_Missense_Mutation_p.E258A|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.E165A|TP53_uc002gio.2_Missense_Mutation_p.E126A	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	258	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> Q (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E258K(37)|p.E258*(12)|p.E258Q(8)|p.E258D(8)|p.0?(7)|p.E258G(7)|p.E258V(5)|p.E258A(5)|p.?(1)|p.E258fs*85(1)|p.E258>XX(1)|p.E258fs*71(1)|p.E258fs*2(1)|p.E258_S260delEDS(1)|p.E258del(1)|p.E258L(1)|p.E258fs*87(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTGGAGTCTTCCAGTGTGAT	0.582		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	29					0	0	0	0	G	7577508	G	G	7577508	3	3	242	1	0	0	0	0	1	0	0	0	16448	1783	62	5	517	5	TP53	17	7577508	Missense_Mutation	SNP	T	TCGA-CV-7254-01A-11D-2012-08	2253917	7577508	73617702	241	44612											
MYH10	4628	broad.mit.edu	37	chr17	8383805	8383805	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctccagctgtgcgatcCgagcttccagacgccgcttc	5	9	9	18	4	0	1	0	0	0	1	5	3	4	1	6	0	3	3	6	0	0	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:8383805C>T	uc002gll.2	-	37	5306	c.5210G>A	c.(5209-5211)CGG>CAG	p.R1737Q	MYH10_uc002glm.2_Missense_Mutation_p.R1768Q|MYH10_uc010cnx.2_Missense_Mutation_p.R1746Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1737	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CTGTGCGATCCGAGCTTCCAG	0.612													10	12					0	0	0	0	T	8383805	T	T	8383805	3	4	242	1	0	0	0	0	1	0	0	0	10083	652	23	1	740	1	MYH10	17	8383805	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	806297	8383805	72811405	242	44613											
TBC1D28	254272	broad.mit.edu	37	chr17	18542504	18542504	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccttcacctccagggcaCtgacgcggggcagctccatc	7	8	10	16	2	1	1	1	1	0	0	4	1	3	1	4	3	2	3	4	3	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:18542504C>G	uc002gud.2	-	6	594	c.182G>C	c.(181-183)AGT>ACT	p.S61T		NM_001039397	NP_001034486	Q2M2D7	TBC28_HUMAN	TBC1 domain family, member 28	61						intracellular	Rab GTPase activator activity			ovary(1)	1						CTCCAGGGCACTGACGCGGGG	0.652													20	31					0	0	0	0	G	18542504	G	G	18542504	3	3	242	1	0	0	0	0	1	0	0	0	15683	565	20	4	470	4	TBC1D28	17	18542504	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	10158699	18542504	62652706	243	44614											
SLC13A2	9058	broad.mit.edu	37	chr17	26822750	26822750	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctccagccattgccatcatCctctccctcctggtggccac	5	10	7	19	0	2	0	1	0	1	0	6	0	5	0	7	2	2	1	7	2	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:26822750C>T	uc002hbh.2	+	10	1453	c.1386C>T	c.(1384-1386)ATC>ATT	p.I462I	SLC13A2_uc010wam.1_Silent_p.I418I|SLC13A2_uc010wan.1_Silent_p.I511I|SLC13A2_uc010wao.1_Silent_p.I419I|SLC13A2_uc002hbi.2_Silent_p.I391I	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	462	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	TTGCCATCATCCTCTCCCTCC	0.612													51	112					0	0	0	0	T	26822750	T	T	26822750	2	4	242	1	0	0	0	0	0	0	0	1	14457	845	30	2		2	SLC13A2	17	26822750	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	8280246	26822750	54372460	244	44615											
MED24	9862	broad.mit.edu	37	chr17	38179592	38179592	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacttgatctgcgtggctGtctgctgcagcacgtcggca	7	10	13	11	3	2	1	0	1	2	0	3	2	2	1	0	2	5	5	0	2	1	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:38179592G>T	uc002htt.2	-	20	2355	c.2042C>A	c.(2041-2043)ACA>AAA	p.T681K	MED24_uc010weq.1_5'Flank|MED24_uc002htr.2_5'Flank|MED24_uc010wer.1_Missense_Mutation_p.T16K|MED24_uc010wes.1_Missense_Mutation_p.T541K|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Missense_Mutation_p.T706K|MED24_uc002htu.2_Missense_Mutation_p.T668K|MED24_uc010cwn.2_Missense_Mutation_p.T668K|MED24_uc010weu.1_Missense_Mutation_p.T591K|MED24_uc010wev.1_Missense_Mutation_p.T631K|MED24_uc010wew.1_Missense_Mutation_p.T622K	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	681					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					CTGCGTGGCTGTCTGCTGCAG	0.612													16	33					1.02788e-11	3.03398e-11	1	0	T	38179592	T	T	38179592	3	4	242	1	0	0	0	0	1	0	0	0	9495	1377	48	4	955	4	MED24	17	38179592	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	11356842	38179592	43015618	245	44616											
PLEKHH3	79990	broad.mit.edu	37	chr17	40825796	40825796	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtgagcacaaaccaggctcGgcgcgggggcagccagggcc	8	2	17	14	4	0	1	0	1	0	0	1	1	0	1	3	5	3	3	3	5	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:40825796G>A	uc002iau.2	-	4	822	c.355C>T	c.(355-357)CGA>TGA	p.R119*	PLEKHH3_uc010cyl.1_5'Flank|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_5'UTR|PLEKHH3_uc002iaw.2_Nonsense_Mutation_p.R119*	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	119	PH.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		AACCAGGCTCGGCGCGGGGGC	0.697													7	5					0	0	0	0	A	40825796	A	A	40825796	4	1	242	1	0	0	0	0	0	1	0	0	12133	1124	39	1	2066	1	PLEKHH3	17	40825796	Nonsense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	2646204	40825796	40369414	246	44617											
EFTUD2	9343	broad.mit.edu	37	chr17	42930947	42930947	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatctggcccccgccccggtGcaggggctcctgggcaacca	5	5	14	17	2	1	0	0	0	1	0	2	1	2	0	6	5	2	3	6	5	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:42930947G>T	uc002ihn.2	-	24	2665	c.2404C>A	c.(2404-2406)CAC>AAC	p.H802N	EFTUD2_uc010wje.1_Missense_Mutation_p.H767N|EFTUD2_uc010wjf.1_Missense_Mutation_p.H792N	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	802						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				CCGCCCCGGTGCAGGGGCTCC	0.592													6	57					5.9392e-07	1.59315e-06	1	0	T	42930947	T	T	42930947	3	4	242	1	0	0	0	0	1	0	0	0	4983	1319	46	4	534	4	EFTUD2	17	42930947	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	2105151	42930947	38264263	247	44618											
TOB1	10140	broad.mit.edu	37	chr17	48941307	48941307	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttcaccaaaaatgttgacAcgtctcctgggaagcttatt	11	13	7	10	1	3	1	1	1	2	0	4	2	3	2	2	1	1	2	2	1	4	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:48941307A>G	uc002isw.2	-	1	107	c.72T>C	c.(70-72)CGT>CGC	p.R24R	TOB1_uc010wmy.1_Silent_p.R24R|TOB1_uc010wmz.1_Silent_p.R24R|uc002isy.2_5'Flank	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	24					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			AAATGTTGACACGTCTCCTGG	0.373													11	101					0	0	0	0	G	48941307	G	G	48941307	2	3	242	1	0	0	0	0	0	0	0	1	16413	146	6	5		5	TOB1	17	48941307	Silent	SNP	A	TCGA-CV-7254-01A-11D-2012-08	6010360	48941307	32253903	248	44619											
EPX	8288	broad.mit.edu	37	chr17	56271376	56271376	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggctcgctggctgcccGccgagtatgaggatgggctg	4	9	16	12	3	1	1	0	1	1	0	2	3	1	2	2	4	1	5	2	4	1	1	rs150719520		TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:56271376G>C	uc002ivq.2	+	5	603	c.517G>C	c.(517-519)GCC>CCC	p.A173P		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	173					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						CTGGCTGCCCGCCGAGTATGA	0.652													13	51					0	0	0	0	C	56271376	C	C	56271376	3	2	242	1	0	0	0	0	1	0	0	0	5224	1087	38	3	535	3	EPX	17	56271376	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	7330069	56271376	24923834	249	44620											
RAD51C	5889	broad.mit.edu	37	chr17	56772501	56772501	+	Frame_Shift_Del	DEL	A	-	-																															ggggtggagtgcccttaatgAaaacaacagaaatttgtggt																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:56772501delA	uc002iwu.2	+	2	397	c.355delA	c.(355-357)AAAfs	p.K119fs	RAD51C_uc002iwt.1_Frame_Shift_Del_p.K119fs|RAD51C_uc010woa.1_Frame_Shift_Del_p.K119fs|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	119					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCCCTTAATGAAAACAACAGA	0.398								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				---	---	---								-	56772501	-	-	56772501	7	5	242	1	0	1	0	1	0	0	0	0	13053	247	9	0	361	0	RAD51C	17	56772501	Frame_Shift_Del	DEL	A	TCGA-CV-7254-01A-11D-2012-08	501125	56772501	24422709	250	44621											
CD300A	11314	broad.mit.edu	37	chr17	72469713	72469713	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aatgcaggaccgtggcgggcCccgtggggggatccctgagt	6	6	18	11	3	0	1	0	1	0	0	1	3	1	3	4	6	1	1	4	6	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:72469713C>A	uc002jkv.2	+	2	400	c.79C>A	c.(79-81)CCC>ACC	p.P27T	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	27	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						CGTGGCGGGCCCCGTGGGGGG	0.562													19	89					1.15919e-05	2.95947e-05	1	0	A	72469713	A	A	72469713	3	1	242	1	0	0	0	0	1	0	0	0	3011	623	22	4	85	4	CD300A	17	72469713	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	15697212	72469713	8725497	251	44622											
QRICH2	84074	broad.mit.edu	37	chr17	74271917	74271917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacctgaggtgttgccagccGaaatctgggcgctctgtggc	6	10	14	11	2	2	1	0	1	2	0	2	2	2	1	3	3	3	2	3	3	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:74271917G>A	uc002jrd.1	-	18	5147	c.4967C>T	c.(4966-4968)TCG>TTG	p.S1656L	QRICH2_uc010wsz.1_Silent_p.F1348F|QRICH2_uc010dgw.1_Missense_Mutation_p.S500L	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1656							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						GTTGCCAGCCGAAATCTGGGC	0.672													10	32					0	0	0	0	A	74271917	A	A	74271917	3	1	242	1	0	0	0	0	1	0	0	0	12945	1059	37	1	32	1	QRICH2	17	74271917	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1802204	74271917	6923293	252	44623											
RNF213	57674	broad.mit.edu	37	chr17	78319512	78319512	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaggaacaactgcagacatGatctactccagagtcaggga	14	6	12	9	0	2	3	1	1	1	2	3	6	3	6	1	3	4	1	1	3	3	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:78319512G>C	uc002jyh.1	+	4	1819	c.1596G>C	c.(1594-1596)ATG>ATC	p.M532I		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CTGCAGACATGATCTACTCCA	0.488													17	106					0	0	0	0	C	78319512	C	C	78319512	3	2	242	1	0	0	0	0	1	0	0	0	13542	1290	45	2	7806	2	RNF213	17	78319512	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	4047595	78319512	2875698	253	44624											
RNF213	57674	broad.mit.edu	37	chr17	78360548	78360548	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcatcagttatgaagtggagCgggacctgactccactgatt	10	11	11	9	1	2	3	2	3	0	0	3	5	3	5	2	2	1	1	2	2	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:78360548C>T	uc002jyh.1	+	38	9221	c.8998C>T	c.(8998-9000)CGG>TGG	p.R3000W	uc002jyi.1_Intron|RNF213_uc010dhx.1_5'UTR	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGAAGTGGAGCGGGACCTGAC	0.572													35	36					0	0	0	0	T	78360548	T	T	78360548	3	4	242	1	0	0	0	0	1	0	0	0	13542	759	27	1	15344	1	RNF213	17	78360548	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	41036	78360548	2834662	254	44625											
LRRC45	201255	broad.mit.edu	37	chr17	79986313	79986313	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcaggtgtcagcaggagcAgctgttccagaccaggcagg	9	7	15	10	0	2	1	2	0	0	1	3	2	3	2	2	4	3	6	2	4	0	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:79986313A>T	uc002kde.2	+	11	1406	c.1166A>T	c.(1165-1167)CAG>CTG	p.Q389L		NM_144999	NP_659436	Q96CN5	LRC45_HUMAN	leucine rich repeat containing 45	389	Potential.					centrosome				pancreas(1)	1	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CAGCAGGAGCAGCTGTTCCAG	0.662													16	87					0	0	0	0	T	79986313	T	T	79986313	3	4	242	1	0	0	0	0	1	0	0	0	9052	188	7	5	1208	5	LRRC45	17	79986313	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	1625765	79986313	1208897	255	44626											
FN3KRP	79672	broad.mit.edu	37	chr17	80684370	80684371	+	Nonsense_Mutation	DNP	GG	TT	TT																															gtgcaggtgaatgactggcaGgaggactgggtcgtgttcta																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr17:80684370_80684371GG>TT	uc002kfu.2	+	5	533_534	c.483_484GG>TT	c.(481-486)CAGGAG>CATTAG	p.161_162QE>H*	FN3KRP_uc010wvr.1_Nonsense_Mutation_p.111_112QE>H*	NM_024619	NP_078895	Q9HA64	KT3K_HUMAN	fructosamine 3 kinase related protein	161_162							kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			ATGACTGGCAGGAGGACTGGGT	0.559													98	207					0	0	0	0	TT	80684371	TT	TT	80684370	4	4	242	1	0	0	0	0	0	1	0	0	5996	991	35	4	501	4	FN3KRP	17	80684370	Nonsense_Mutation	DNP	GG	TCGA-CV-7254-01A-11D-2012-08	698057	80684370	510840	256	44627											
EPB41L3	23136	broad.mit.edu	37	chr18	5397303	5397303	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagaagcatccccactcgcGtgcaccacacgccgctcctc	9	6	7	19	4	0	1	0	0	0	1	4	1	2	1	5	0	2	3	5	0	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr18:5397303G>T	uc002kmt.1	-	18	2681	c.2595C>A	c.(2593-2595)CAC>CAA	p.H865Q	EPB41L3_uc010wzh.1_Missense_Mutation_p.H696Q|EPB41L3_uc002kmu.1_Missense_Mutation_p.H643Q|EPB41L3_uc010dkq.1_Missense_Mutation_p.H534Q|EPB41L3_uc002kms.1_Missense_Mutation_p.H100Q|EPB41L3_uc010wze.1_Missense_Mutation_p.H170Q|EPB41L3_uc010wzf.1_Missense_Mutation_p.H162Q|EPB41L3_uc010wzg.1_Missense_Mutation_p.H137Q|EPB41L3_uc010dkr.2_Missense_Mutation_p.H257Q	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	865	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CCCCACTCGCGTGCACCACAC	0.617													29	41					7.68411e-24	2.47012e-23	1	0	T	5397303	T	T	5397303	3	4	242	1	0	0	0	0	1	0	0	0	5178	1136	40	3	688	3	EPB41L3	18	5397303	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08		5397303	72679945	257	44628											
ANKRD12	23253	broad.mit.edu	37	chr18	9256148	9256148	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacagggagctagataaaaaGgaaaaatctagagataaaga	22	5	11	3	0	1	3	0	0	1	3	1	7	1	5	0	2	1	1	0	2	9	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr18:9256148G>A	uc002knv.2	+	9	3140	c.2883G>A	c.(2881-2883)AAG>AAA	p.K961K	ANKRD12_uc002knw.2_Silent_p.K938K|ANKRD12_uc002knx.2_Silent_p.K938K|ANKRD12_uc010dkx.1_Silent_p.K668K	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	961						nucleus				ovary(2)|central_nervous_system(1)	3						TAGATAAAAAGGAAAAATCTA	0.284													4	19					0	0	0	0	A	9256148	A	A	9256148	2	1	242	1	0	0	0	0	0	0	0	1	640	991	35	4		4	ANKRD12	18	9256148	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	3858845	9256148	68821100	258	44629											
PIK3C3	5289	broad.mit.edu	37	chr18	39618758	39618758	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaagctgttacggaaagAaaatctggacttgaaattga	17	11	9	4	1	1	3	0	2	1	1	1	5	1	5	0	2	2	2	0	2	7	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr18:39618758A>C	uc002lap.2	+	18	2040	c.1982A>C	c.(1981-1983)GAA>GCA	p.E661A	PIK3C3_uc010xcl.1_Missense_Mutation_p.E598A|PIK3C3_uc002laq.2_Missense_Mutation_p.E146A|PIK3C3_uc002lar.1_Missense_Mutation_p.E45A	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	661	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						TTACGGAAAGAAAATCTGGAC	0.299										TSP Lung(28;0.18)			10	30					0	0	0	0	C	39618758	C	C	39618758	3	2	242	1	0	0	0	0	1	0	0	0	11967	246	9	5	2052	5	PIK3C3	18	39618758	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	30362610	39618758	38458490	259	44630											
BSG	682	broad.mit.edu	37	chr19	571494	571494	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccgcgttgctgagagtctgGgtttacgcgtcacctcgggc	4	10	14	13	5	2	1	1	1	1	1	3	2	2	1	2	2	2	3	2	2	1	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:571494G>A	uc002loz.2	+						BSG_uc002loy.2_5'UTR|BSG_uc002lpa.2_5'Flank|BSG_uc002lpb.2_5'Flank|BSG_uc010drr.2_5'Flank	NM_001728	NP_001719	P35613	BASI_HUMAN	basigin isoform 1 precursor						blood coagulation|cell surface receptor linked signaling pathway|leukocyte migration|pyruvate metabolic process	Golgi membrane|integral to membrane|melanosome	lactate transmembrane transporter activity|mannose binding|protein binding				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		tgagagtctgggtttacgcgt	0.229													4	27					0	0	0	0	A	571494	A	A	571494	1	1	242	0	1	0	0	0	0	0	0	0	1534	1247	43	4		4	BSG	19	571494	5'Flank	SNP	G	TCGA-CV-7254-01A-11D-2012-08		571494	58557489	260	44631											
FAM108A1	81926	broad.mit.edu	37	chr19	1881347	1881347	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctgtactggaagtcggcAcgctccgtcaggtgcagctt	6	10	14	11	3	1	0	1	0	0	0	3	1	2	1	1	4	3	6	1	4	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:1881347A>G	uc002lug.2	-	2	625	c.219T>C	c.(217-219)CGT>CGC	p.R73R	FAM108A1_uc002lud.2_Silent_p.R73R|FAM108A1_uc002lue.2_Silent_p.R73R|FAM108A1_uc002luf.2_Silent_p.R73R	NM_001130111	NP_001123583	Q96GS6	F18A1_HUMAN	hypothetical protein LOC81926 isoform 2	73						extracellular region	hydrolase activity				0		Ovarian(11;0.000137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGTCGGCACGCTCCGTCA	0.716													4	52					0	0	0	0	G	1881347	G	G	1881347	2	3	242	1	0	0	0	0	0	0	0	1	5419	146	6	5		5	FAM108A1	19	1881347	Silent	SNP	A	TCGA-CV-7254-01A-11D-2012-08	1309853	1881347	57247636	261	44632											
VAV1	7409	broad.mit.edu	37	chr19	6854109	6854109	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgaggggagatctatggccgGgtgaggcaggcagggctggg	7	5	22	7	2	1	2	0	1	1	1	1	4	1	2	1	8	0	3	1	8	1	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:6854109G>T	uc002mfu.1	+	26	2581	c.2484G>T	c.(2482-2484)CGG>CGT	p.R828R	VAV1_uc010xjh.1_Silent_p.R796R|VAV1_uc010dva.1_Silent_p.R806R|VAV1_uc002mfv.1_Silent_p.R773R	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	828	SH3 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						TCTATGGCCGGGTGAGGCAGG	0.622													8	31					3.09899e-07	8.39793e-07	1	0	T	6854109	T	T	6854109	2	4	242	1	0	0	0	0	0	0	0	1	17199	1246	43	4		4	VAV1	19	6854109	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	4972762	6854109	52274874	262	44633											
ICAM1	3383	broad.mit.edu	37	chr19	10385697	10385697	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acagctaaaaccttcctcacCgtgtactgtgagtaactgag	12	10	8	11	1	1	2	1	2	0	0	2	2	2	2	3	0	4	3	3	0	4	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:10385697C>A	uc002mnq.2	+	2	643	c.324C>A	c.(322-324)ACC>ACA	p.T108T	ICAM1_uc010xle.1_Intron	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	108	Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	CCTTCCTCACCGTGTACTGTG	0.552													22	104					3.62473e-10	1.05038e-09	1	0	A	10385697	A	A	10385697	2	1	242	1	0	0	0	0	0	0	0	1	7518	639	23	3		3	ICAM1	19	10385697	Silent	SNP	C	TCGA-CV-7254-01A-11D-2012-08	3531588	10385697	48743286	263	44634											
SMARCA4	6597	broad.mit.edu	37	chr19	11138619	11138619	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgcggctttaaatacctcagGcttgatggtgagtatgagcc	9	11	12	9	2	1	3	1	3	0	0	1	3	1	3	2	3	2	3	2	3	4	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:11138619G>T	uc002mqf.3	+	24	3659	c.3375G>T	c.(3373-3375)AGG>AGT	p.R1125S	SMARCA4_uc010dxp.2_Missense_Mutation_p.R1125S|SMARCA4_uc010dxo.2_Missense_Mutation_p.R1125S|SMARCA4_uc002mqg.1_Missense_Mutation_p.R1125S|SMARCA4_uc010dxq.2_Missense_Mutation_p.R1125S|SMARCA4_uc010dxr.2_Missense_Mutation_p.R1125S|SMARCA4_uc002mqj.3_Missense_Mutation_p.R1125S|SMARCA4_uc010dxs.2_Missense_Mutation_p.R1125S|SMARCA4_uc010dxt.1_Missense_Mutation_p.R345S|SMARCA4_uc002mqh.3_Missense_Mutation_p.R248S|SMARCA4_uc002mqi.1_Missense_Mutation_p.R328S	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1125	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(2)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AATACCTCAGGCTTGATGGTG	0.512			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				43	89					2.54354e-34	8.34533e-34	1	0	T	11138619	T	T	11138619	3	4	242	1	0	0	0	0	1	0	0	0	14834	1194	42	4	3465	4	SMARCA4	19	11138619	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	752922	11138619	47990364	264	44635											
C19orf39	126074	broad.mit.edu	37	chr19	11486363	11486363	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattgccttacttctagacAcagctgcccacttcagccac	9	11	5	16	0	3	1	2	0	1	1	3	1	3	1	3	0	5	1	3	0	2	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:11486363A>T	uc002mrg.1	+	2	398	c.361A>T	c.(361-363)ACA>TCA	p.T121S		NM_175871	NP_787067	Q6NVH7	CS039_HUMAN	hypothetical protein LOC126074	121											0						ACTTCTAGACACAGCTGCCCA	0.637													76	54					0	0	0	0	T	11486363	T	T	11486363	3	4	242	1	0	0	0	0	1	0	0	0	1931	159	6	5	367	5	C19orf39	19	11486363	Missense_Mutation	SNP	A	TCGA-CV-7254-01A-11D-2012-08	347744	11486363	47642620	265	44636											
SIN3B	23309	broad.mit.edu	37	chr19	16977356	16977356	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcaacgagatcgagagcGtctacgacgaggtaaagcct	12	7	12	10	5	2	2	1	0	1	2	3	6	2	2	1	1	5	2	1	1	4	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:16977356G>T	uc002ney.1	+	13	1905	c.1891G>T	c.(1891-1893)GTC>TTC	p.V631F	SIN3B_uc002nez.1_Missense_Mutation_p.V599F|SIN3B_uc010xpi.1_Missense_Mutation_p.V189F	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	631					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						GATCGAGAGCGTCTACGACGA	0.622													29	20					2.65835e-16	8.30995e-16	1	0	T	16977356	T	T	16977356	3	4	242	1	0	0	0	0	1	0	0	0	14391	1145	40	3	1941	3	SIN3B	19	16977356	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	5490993	16977356	42151627	266	44637											
GMIP	51291	broad.mit.edu	37	chr19	19753398	19753398	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggaagatgtcactgtacCtcttcctgccctcaggacct	7	11	8	15	1	3	1	2	0	1	1	5	3	5	3	5	2	2	1	5	2	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:19753398C>G	uc002nnd.2	-	2	167	c.50G>C	c.(49-51)AGG>ACG	p.R17T	GMIP_uc010xrb.1_Missense_Mutation_p.R17T|GMIP_uc010xrc.1_Missense_Mutation_p.R17T	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	17					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						GTCACTGTACCTCTTCCTGCC	0.592													89	64					0	0	0	0	G	19753398	G	G	19753398	3	3	242	1	0	0	0	0	1	0	0	0	6528	681	24	4	2942	4	GMIP	19	19753398	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	2776042	19753398	39375585	267	44638											
ZNF257	113835	broad.mit.edu	37	chr19	22271543	22271543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttaaccagtcctcagccCttactcgacataagatgatt	11	12	5	13	1	1	2	1	1	0	1	3	3	2	2	4	0	3	0	4	0	3	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:22271543C>T	uc010ecx.2	+	4	1160	c.991C>T	c.(991-993)CTT>TTT	p.L331F	ZNF257_uc010ecy.2_Missense_Mutation_p.L299F	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	331	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTCCTCAGCCCTTACTCGACA	0.423													23	41					0	0	0	0	T	22271543	T	T	22271543	3	4	242	1	0	0	0	0	1	0	0	0	17867	681	24	4	1005	4	ZNF257	19	22271543	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	2518145	22271543	36857440	268	44639											
LGALS14	56891	broad.mit.edu	37	chr19	40197266	40197266	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactgcctgtttccttgccTgttggttcgtgcgtgataat	5	16	10	10	2	0	1	0	1	0	0	2	1	1	1	3	1	3	3	3	1	1	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:40197266T>C	uc002omg.2	+	2	268	c.45T>C	c.(43-45)CCT>CCC	p.P15P	LGALS14_uc002omf.2_Silent_p.P44P	NM_020129	NP_064514	Q8TCE9	PPL13_HUMAN	lectin, galactoside-binding, soluble, 14 isoform	15	Galectin.					nucleus	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;4.39e-06)|all_lung(34;6.76e-08)|Lung NSC(34;7.98e-08)|Ovarian(47;0.06)	Myeloproliferative disorder(2;0.0741)	Epithelial(26;1.08e-24)|OV - Ovarian serous cystadenocarcinoma(5;1.92e-24)|all cancers(26;4.12e-22)			TTTCCTTGCCTGTTGGTTCGT	0.498													66	131					0	0	0	0	C	40197266	C	C	40197266	2	2	242	1	0	0	0	0	0	0	0	1	8781	1567	55	5		5	LGALS14	19	40197266	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08	17925723	40197266	18931717	269	44640											
MAP3K10	4294	broad.mit.edu	37	chr19	40710471	40710471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttggccgtggcgtatggcGtggctatgaataagctgacg	7	10	15	9	4	0	2	0	2	0	0	0	2	0	2	2	4	1	3	2	4	4	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:40710471G>A	uc002ona.2	+	3	1231	c.943G>A	c.(943-945)GTG>ATG	p.V315M	MAP3K10_uc002onb.2_Translation_Start_Site	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	315	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						GGCGTATGGCGTGGCTATGAA	0.682													7	41					0	0	0	0	A	40710471	A	A	40710471	3	1	242	1	0	0	0	0	1	0	0	0	9297	1145	40	1	953	1	MAP3K10	19	40710471	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	513205	40710471	18418512	270	44641											
KCNN4	3783	broad.mit.edu	37	chr19	44271786	44271786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccagcttccccgccagcGtgtcaatctgtttctccagg	6	11	8	16	2	3	0	1	0	2	0	6	0	5	0	5	1	2	2	5	1	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:44271786G>A	uc002oxl.2	-	8	1589	c.1193C>T	c.(1192-1194)ACG>ATG	p.T398M	KCNN4_uc010eiz.2_Missense_Mutation_p.T322M	NM_002250	NP_002241	O15554	KCNN4_HUMAN	intermediate conductance calcium-activated	398					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			ovary(2)	2		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	CCCCGCCAGCGTGTCAATCTG	0.602													33	31					0	0	0	0	A	44271786	A	A	44271786	3	1	242	1	0	0	0	0	1	0	0	0	8120	1145	40	1	94	1	KCNN4	19	44271786	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	3561315	44271786	14857197	271	44642											
TOMM40	10452	broad.mit.edu	37	chr19	45406351	45406351	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagctcccacccctgcccctGacactggcccttggggcctt	5	8	9	19	0	0	1	0	1	0	0	1	1	1	1	7	3	2	1	7	3	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:45406351G>A	uc002ozx.3	+	10	1112	c.1011G>A	c.(1009-1011)CTG>CTA	p.L337L	TOMM40_uc002ozy.3_Silent_p.L337L|TOMM40_uc002paa.3_Silent_p.L337L|TOMM40_uc002ozz.2_3'UTR|APOE_uc002pab.2_5'Flank	NM_006114	NP_006105	O96008	TOM40_HUMAN	translocase of outer mitochondrial membrane 40	337					protein targeting to mitochondrion	integral to membrane of membrane fraction|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex|pore complex	porin activity|protein transmembrane transporter activity|voltage-gated anion channel activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)			OV - Ovarian serous cystadenocarcinoma(262;0.0033)|Epithelial(262;0.176)		CCCTGCCCCTGACACTGGCCC	0.627													15	52					0	0	0	0	A	45406351	A	A	45406351	2	1	242	1	0	0	0	0	0	0	0	1	16424	1277	45	2		2	TOMM40	19	45406351	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1134565	45406351	13722632	272	44643											
NLRP12	91662	broad.mit.edu	37	chr19	54313633	54313633	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagtggtggtcctggacGtctgtctcaacagcccccca	6	9	11	15	1	2	0	1	0	2	0	4	1	3	1	4	3	3	1	4	3	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:54313633G>T	uc002qch.3	-	3	1500	c.1280C>A	c.(1279-1281)ACG>AAG	p.T427K	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.T427K|NLRP12_uc002qcj.3_Missense_Mutation_p.T427K|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.T427K	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	427	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GGTCCTGGACGTCTGTCTCAA	0.642													59	96					3.53049e-34	1.15358e-33	1	0	T	54313633	T	T	54313633	3	4	242	1	0	0	0	0	1	0	0	0	10528	1145	40	3	2033	3	NLRP12	19	54313633	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	8907282	54313633	4815350	273	44644											
LILRA6	79168	broad.mit.edu	37	chr19	54744856	54744856	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcccagcctggggctgctggCcagggcgctggaggaagtca	6	5	18	12	1	1	0	1	0	0	0	1	2	1	2	3	6	2	3	3	6	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:54744856C>G	uc002qeu.1	-	5	930	c.806G>C	c.(805-807)GGC>GCC	p.G269A	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Missense_Mutation_p.G269A|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Missense_Mutation_p.G269A|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.G269A|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Missense_Mutation_p.G269A|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Missense_Mutation_p.G269A|LILRA6_uc010yeq.1_Missense_Mutation_p.G269A|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.G130A	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	269	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGCTGCTGGCCAGGGCGCTG	0.642													21	68					0	0	0	0	G	54744856	G	G	54744856	3	3	242	1	0	0	0	0	1	0	0	0	8830	739	26	4	655	4	LILRA6	19	54744856	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	431223	54744856	4384127	274	44645											
LILRB5	10990	broad.mit.edu	37	chr19	54755925	54755925	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcggggcctcacccgagcatCcatctccaccccgtccttgg	5	7	10	19	3	2	0	1	0	1	0	5	1	4	0	7	3	1	1	7	3	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:54755925C>G	uc002qex.2	-	12	1729	c.1618G>C	c.(1618-1620)GAT>CAT	p.D540H	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.D532H|LILRB5_uc002qey.2_Missense_Mutation_p.D541H|LILRB5_uc002qez.2_Missense_Mutation_p.D441H|LILRB5_uc002qfa.1_3'UTR	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	540	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACCCGAGCATCCATCTCCACC	0.627													4	160					0	0	0	0	G	54755925	G	G	54755925	3	3	242	1	0	0	0	0	1	0	0	0	8835	855	30	2	162	2	LILRB5	19	54755925	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	11069	54755925	4373058	275	44646											
ZNF524	147807	broad.mit.edu	37	chr19	56114033	56114033	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccgcgaggcgggcgagctGgcgcaccaccaccgcgtgca	6	4	15	16	7	0	0	0	0	0	0	1	2	1	0	4	3	2	3	4	3	0	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:56114033G>A	uc002qlk.1	+	2	638	c.555G>A	c.(553-555)CTG>CTA	p.L185L	FIZ1_uc002qlj.3_5'Flank	NM_153219	NP_694951	Q96C55	ZN524_HUMAN	zinc finger protein 524	185	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CGGGCGAGCTGGCGCACCACC	0.736													10	13					0	0	0	0	A	56114033	A	A	56114033	2	1	242	1	0	0	0	0	0	0	0	1	18033	1335	47	4		4	ZNF524	19	56114033	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1358108	56114033	3014950	276	44647											
ZNF547	284306	broad.mit.edu	37	chr19	57888603	57888603	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctatctacccagaataccCagccctgtgagacatgtagc	11	9	8	13	0	2	2	0	1	2	2	2	3	2	2	3	0	4	1	3	0	5	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr19:57888603C>A	uc002qol.2	+	4	452	c.259C>A	c.(259-261)CAG>AAG	p.Q87K	ZNF547_uc002qpm.3_Missense_Mutation_p.Q13K|ZNF547_uc010ygx.1_Missense_Mutation_p.Q87K	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	87	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCAGAATACCCAGCCCTGTGA	0.547													19	31					9.7654e-05	0.000243064	1	0	A	57888603	A	A	57888603	3	1	242	1	0	0	0	0	1	0	0	0	18046	595	21	4	269	4	ZNF547	19	57888603	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	1774570	57888603	1240380	277	44648											
TGM6	343641	broad.mit.edu	37	chr20	2413288	2413288	+	Nonstop_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgtggccactgccaagtGatggatcatgagggactgag	10	8	14	9	0	1	3	1	3	0	0	1	5	1	5	3	3	1	0	3	3	1	0			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr20:2413288G>T	uc002wfy.1	+	13	2181	c.2120G>T	c.(2119-2121)TGA>TTA	p.*707L	TGM6_uc010gal.1_3'UTR	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	707					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	ACTGCCAAGTGATGGATCATG	0.493													18	62					1.45105e-14	4.41431e-14	1	0	T	2413288	T	T	2413288	4	4	242	1	0	0	0	0	0	0	0	0	15900	1285	45	2	2170	2	TGM6	20	2413288	Nonstop_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08		2413288	60612232	278	44649											
SIGLEC1	6614	broad.mit.edu	37	chr20	3678550	3678550	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agggttgtgaatctccacacGcagcaagttgggggctttgg	8	10	15	8	1	1	1	0	1	1	0	2	1	1	1	1	4	1	5	1	4	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr20:3678550G>A	uc002wja.2	-	8	2017	c.2017C>T	c.(2017-2019)CGT>TGT	p.R673C	SIGLEC1_uc002wiz.3_Missense_Mutation_p.R673C	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	673	Ig-like C2-type 6.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding	p.1670_1673del(1)		pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						ATCTCCACACGCAGCAAGTTG	0.612													10	50					0	0	0	0	A	3678550	A	A	3678550	3	1	242	1	0	0	0	0	1	0	0	0	14370	1087	38	1	3168	1	SIGLEC1	20	3678550	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	1265262	3678550	59346970	279	44650											
HAO1	54363	broad.mit.edu	37	chr20	7875861	7875861	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccatgtttaacagcctccctGgcatcatcacctggagagag	10	9	9	13	0	2	1	2	0	0	1	3	3	3	2	4	2	2	2	4	2	1	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr20:7875861G>T	uc002wmw.1	-	5	756	c.732C>A	c.(730-732)GCC>GCA	p.A244A	HAO1_uc010gbu.2_Silent_p.A244A	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	244	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						CAGCCTCCCTGGCATCATCAC	0.512													11	70					0.00010058	0.000248786	1	0	T	7875861	T	T	7875861	2	4	242	1	0	0	0	0	0	0	0	1	6990	1335	47	4		4	HAO1	20	7875861	Silent	SNP	G	TCGA-CV-7254-01A-11D-2012-08	4197311	7875861	55149659	280	44651											
REM1	28954	broad.mit.edu	37	chr20	30070276	30070276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagacttggcccgctgccgaGaagtctctgtggaaggtgag	8	8	15	10	2	1	3	0	1	1	2	2	5	1	4	2	3	1	1	2	3	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr20:30070276G>A	uc002wwa.2	+	4	894	c.610G>A	c.(610-612)GAA>AAA	p.E204K		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	204					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CCGCTGCCGAGAAGTCTCTGT	0.617													11	46					0	0	0	0	A	30070276	A	A	30070276	3	1	242	1	0	0	0	0	1	0	0	0	13287	943	33	2	620	2	REM1	20	30070276	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	22194415	30070276	32955244	281	44652											
BAGE2	85319	broad.mit.edu	37	chr21	11098776	11098776	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctaccgctcaggccgccCtcctaacactccagctgcgc	6	7	7	21	3	1	0	1	0	0	0	4	0	4	0	6	1	4	2	6	1	2	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr21:11098776C>A	uc002yit.1	-	1	150	c.-58G>T	c.(-60--56)GAGGG>GATGG		BAGE_uc002yix.2_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tcaggccgccctcctaacact	0													15	120					4.7546e-09	1.34827e-08	1	0	A	11098776	A	A	11098776	1	1	242	1	0	0	0	0	0	0	0	0	1294	696	24	4		4	BAGE2	21	11098776	Translation_Start_Site	SNP	C	TCGA-CV-7254-01A-11D-2012-08		11098776	37031119	282	44653											
HSF2BP	11077	broad.mit.edu	37	chr21	45050217	45050217	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttactcgtgacaattccaGccagagcgaaaacaaactga	16	7	7	11	2	0	3	0	2	0	1	2	4	1	3	2	0	5	0	2	0	5	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr21:45050217G>A	uc002zdi.2	-	6	892	c.560C>T	c.(559-561)GCT>GTT	p.A187V	HSF2BP_uc011aey.1_Missense_Mutation_p.A112V	NM_007031	NP_008962	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding	187					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.18)		GACAATTCCAGCCAGAGCGAA	0.279													3	30					0	0	0	0	A	45050217	A	A	45050217	3	1	242	1	0	0	0	0	1	0	0	0	7436	971	34	4	460	4	HSF2BP	21	45050217	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	33951441	45050217	3079678	283	44654											
BCL2L13	23786	broad.mit.edu	37	chr22	18210216	18210216	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgccgctgtctgagggcaaGtctatactgctgtttggagg	7	12	14	8	1	2	1	0	1	2	0	2	2	2	2	1	3	3	4	1	3	3	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr22:18210216G>C	uc002zmw.2	+	7	1592	c.1374G>C	c.(1372-1374)AAG>AAC	p.K458N	BCL2L13_uc002zmx.2_Missense_Mutation_p.K296N|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Missense_Mutation_p.K296N|BCL2L13_uc011agk.1_Missense_Mutation_p.K334N|BCL2L13_uc010gqz.2_Missense_Mutation_p.K178N|BCL2L13_uc002zmz.2_Missense_Mutation_p.K296N|BCL2L13_uc002zna.2_Missense_Mutation_p.K178N	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	458	B; approximate.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		CTGAGGGCAAGTCTATACTGC	0.597													11	188					0	0	0	0	C	18210216	C	C	18210216	3	2	242	1	0	0	0	0	1	0	0	0	1373	1020	36	4	1396	4	BCL2L13	22	18210216	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08		18210216	33094350	284	44655											
RNF215	200312	broad.mit.edu	37	chr22	30782669	30782669	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tattctcctggtggaactggGccgcctgctccttgcccacg	4	11	11	15	2	1	0	0	0	1	0	3	1	2	1	5	3	3	1	5	3	2	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr22:30782669G>A	uc003ahp.2	-	2	365	c.365C>T	c.(364-366)GCC>GTC	p.A122V	RNF215_uc011akw.1_Missense_Mutation_p.A27V	NM_001017981	NP_001017981	Q9Y6U7	RN215_HUMAN	ring finger protein 215	122	Extracellular (Potential).					integral to membrane	zinc ion binding			central_nervous_system(1)	1						GTGGAACTGGGCCGCCTGCTC	0.637													16	71					0	0	0	0	A	30782669	A	A	30782669	3	1	242	1	0	0	0	0	1	0	0	0	13544	1203	42	4	800	4	RNF215	22	30782669	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	12572453	30782669	20521897	285	44656											
ADSL	158	broad.mit.edu	37	chr22	40760320	40760320	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaagagctgcctttcatggCcacagagaacatcatcatgg	12	8	10	11	0	3	2	3	0	0	2	3	3	3	2	2	2	3	2	2	2	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr22:40760320C>T	uc003ayp.3	+	11	1201	c.1142C>T	c.(1141-1143)GCC>GTC	p.A381V	ADSL_uc003ays.3_Missense_Mutation_p.A381V|ADSL_uc003ayq.3_Missense_Mutation_p.A395V|ADSL_uc003ayr.3_Missense_Mutation_p.A157V|ADSL_uc003ayt.3_Missense_Mutation_p.A366V	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	381					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1						CCTTTCATGGCCACAGAGAAC	0.478													6	38					0	0	0	0	T	40760320	T	T	40760320	3	4	242	1	0	0	0	0	1	0	0	0	346	739	26	4	1184	4	ADSL	22	40760320	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	9977651	40760320	10544246	286	44657											
NUP50	10762	broad.mit.edu	37	chr22	45571834	45571834	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtaccttctggaggaggAcgcttttctggatttggtag	6	14	15	6	1	2	0	0	0	2	0	2	4	2	4	1	6	1	3	1	6	2	6			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chr22:45571834A>G	uc003bfr.2	+	4	675	c.213A>G	c.(211-213)GGA>GGG	p.G71G	NUP50_uc003bfs.2_Silent_p.G43G|NUP50_uc011aqn.1_Intron|NUP50_uc003bft.2_Silent_p.G43G|NUP50_uc011aqo.1_5'Flank	NM_007172	NP_009103	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa isoform b	71	Gly-rich.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CTGGAGGAGGACGCTTTTCTG	0.493													8	112					0	0	0	0	G	45571834	G	G	45571834	2	3	242	1	0	0	0	0	0	0	0	1	10820	262	10	5		5	NUP50	22	45571834	Silent	SNP	A	TCGA-CV-7254-01A-11D-2012-08	4811514	45571834	5732732	287	44658											
CYBB	1536	broad.mit.edu	37	chrX	37651299	37651299	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatggtggcatggatgatTgcacttcactctggtaagtt	11	13	11	6	0	2	1	1	1	1	0	2	2	2	2	0	4	1	4	0	4	3	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chrX:37651299T>C	uc004ddr.2	+	4	385	c.324T>C	c.(322-324)ATT>ATC	p.I108I	CYBB_uc011mke.1_RNA|CYBB_uc011mkf.1_Silent_p.I76I|CYBB_uc011mkg.1_5'UTR	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	108	Ferric oxidoreductase.|Helical; (Potential).				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						CATGGATGATTGCACTTCACT	0.383													5	12					0	0	0	0	C	37651299	C	C	37651299	2	2	242	1	0	0	0	0	0	0	0	1	4150	1800	63	5		5	CYBB	23	37651299	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08		37651299	117619261	288	44659											
RPS6KA6	27330	broad.mit.edu	37	chrX	83411200	83411200	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttaacaactccttcatcCtgtaaaaagaaatccaaaca	17	11	2	11	0	2	1	1	0	1	1	5	1	5	1	3	0	3	1	3	0	7	4			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chrX:83411200C>A	uc004eej.1	-	3	219	c.142_splice	c.e3-1	p.D48_splice	RPS6KA6_uc011mqt.1_Splice_Site_p.D48_splice|RPS6KA6_uc011mqu.1_Splice_Site|RPS6KA6_uc010nmo.1_Splice_Site	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6						axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						CTCCTTCATCCTGTAAAAAGA	0.358													5	6					0.00116845	0.00279441	1	0	A	83411200	A	A	83411200	5	1	242	1	0	0	0	0	0	0	1	0	13720	695	24	4	2176	4	RPS6KA6	23	83411200	Splice_Site	SNP	C	TCGA-CV-7254-01A-11D-2012-08	45759901	83411200	71859360	289	44660											
TGIF2LX	90316	broad.mit.edu	37	chrX	89177580	89177580	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggcccttgccaaagggcCagatgtcaagagagaagcaa	13	6	13	9	0	1	3	1	0	0	3	1	4	1	3	3	2	2	1	3	2	4	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chrX:89177580C>A	uc004efe.2	+	2	545	c.496C>A	c.(496-498)CAG>AAG	p.Q166K		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	166						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GCCAAAGGGCCAGATGTCAAG	0.592													11	21					6.40141e-05	0.000160338	1	0	A	89177580	A	A	89177580	3	1	242	1	0	0	0	0	1	0	0	0	15893	595	21	4	498	4	TGIF2LX	23	89177580	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	5766380	89177580	66092980	290	44661											
RBM41	55285	broad.mit.edu	37	chrX	106312633	106312633	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggttcttcaggtataatacCtaaaacaaattgaggatcaa	17	11	7	6	0	3	1	2	1	1	0	3	2	3	2	1	3	2	2	1	3	7	7			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chrX:106312633C>G	uc004emz.2	-	6	959	c.928_splice	c.e6-1	p.V310_splice	RBM41_uc004emy.1_Splice_Site_p.V310_splice	NM_018301	NP_060771	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41								nucleotide binding|RNA binding			ovary(1)	1						GGTATAATACCTAAAACAAAT	0.313													37	65					0	0	0	0	G	106312633	G	G	106312633	5	3	242	1	0	0	0	0	0	0	1	0	13200	695	24	4	331	4	RBM41	23	106312633	Splice_Site	SNP	C	TCGA-CV-7254-01A-11D-2012-08	17135053	106312633	48957927	291	44662											
IRS4	8471	broad.mit.edu	37	chrX	107977802	107977803	+	Frame_Shift_Ins	INS	-	C	C																															tcccacttcctgagcctttgINSccccccccagagttcttgcc																										TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chrX:107977802_107977803insC	uc004eoc.2	-	1	1805_1806	c.1772_1773insG	c.(1771-1773)GGCfs	p.G591fs		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	591						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTGAGCCTTTGCCCCCCCCAGA	0.545													---	---	---								C	107977803	C	C	107977802	7	5	242	1	0	1	1	0	0	0	0	0	7881	1306	46	0	2004	0	IRS4	23	107977802	Frame_Shift_Ins	INS	-	TCGA-CV-7254-01A-11D-2012-08	1665169	107977802	47292758	292	44663											
DCX	1641	broad.mit.edu	37	chrX	110576307	110576307	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagagaaaaatcatcctgAgcatagcgaaatttttcagg	15	10	8	8	1	2	2	2	1	0	1	4	4	4	2	2	1	2	1	2	1	4	3			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chrX:110576307A>T	uc004epd.2	-	4	1195	c.1023T>A	c.(1021-1023)GCT>GCA	p.A341A	DCX_uc011msv.1_Silent_p.A341A|DCX_uc004epe.2_Silent_p.A260A|DCX_uc004epf.2_Silent_p.A260A|DCX_uc004epg.2_Silent_p.A260A	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	341	Doublecortin 2.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						AATCATCCTGAGCATAGCGAA	0.393													8	5					0	0	0	0	T	110576307	T	T	110576307	2	4	242	1	0	0	0	0	0	0	0	1	4335	291	11	5		5	DCX	23	110576307	Silent	SNP	A	TCGA-CV-7254-01A-11D-2012-08	2598505	110576307	44694253	293	44664											
ATP1B4	23439	broad.mit.edu	37	chrX	119509289	119509289	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccggggcagtacttcatcCaagatggcaatgaggatgag	11	7	13	10	1	1	3	1	2	0	1	2	4	2	4	3	4	1	3	3	4	3	2			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chrX:119509289C>A	uc004esr.2	+	5	709	c.625C>A	c.(625-627)CAA>AAA	p.Q209K	ATP1B4_uc004esq.2_Missense_Mutation_p.Q205K|ATP1B4_uc011mtx.1_Missense_Mutation_p.Q174K|ATP1B4_uc011mty.1_Missense_Mutation_p.Q166K	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	209	Perinuclear space (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						GTACTTCATCCAAGATGGCAA	0.458													109	34					2.34315e-34	7.71977e-34	1	0	A	119509289	A	A	119509289	3	1	242	1	0	0	0	0	1	0	0	0	1137	595	21	4	643	4	ATP1B4	23	119509289	Missense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	8932982	119509289	35761271	294	44665											
BCORL1	63035	broad.mit.edu	37	chrX	129154964	129154964	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctacctctccacagtgccGgaagctgcccagtgaccccc	7	7	8	19	1	2	1	0	1	2	0	3	2	2	2	6	1	4	1	6	1	2	1			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chrX:129154964G>T	uc004evb.1	+	5	3560	c.3446G>T	c.(3445-3447)CGG>CTG	p.R1149L	BCORL1_uc010nrd.1_Missense_Mutation_p.R1051L	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1149					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CCACAGTGCCGGAAGCTGCCC	0.552													41	16					8.01111e-26	2.5857e-25	1	0	T	129154964	T	T	129154964	3	4	242	1	0	0	0	0	1	0	0	0	1389	1116	39	3	3460	3	BCORL1	23	129154964	Missense_Mutation	SNP	G	TCGA-CV-7254-01A-11D-2012-08	9645675	129154964	26115596	295	44666											
IGSF1	3547	broad.mit.edu	37	chrX	130408088	130408088	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgaggccacttcttccactCtatggctagcactaccccca	8	10	6	17	1	2	0	0	0	2	0	4	1	3	0	4	2	2	2	4	2	3	5			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chrX:130408088C>A	uc004ewd.2	-	19	4082	c.3844G>T	c.(3844-3846)GAG>TAG	p.E1282*	IGSF1_uc004ewe.3_Nonsense_Mutation_p.E1276*|IGSF1_uc004ewf.2_Nonsense_Mutation_p.E1262*	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1282	Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						TTCTTCCACTCTATGGCTAGC	0.502													120	84					2.28331e-34	7.55394e-34	1	0	A	130408088	A	A	130408088	4	1	242	1	0	0	0	0	0	1	0	0	7635	922	32	2	174	2	IGSF1	23	130408088	Nonsense_Mutation	SNP	C	TCGA-CV-7254-01A-11D-2012-08	1253124	130408088	24862472	296	44667											
CXorf66	347487	broad.mit.edu	37	chrX	139038574	139038574	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagtctagcttacataatttTtctaggctgcctttcttatg	8	19	6	8	0	3	0	0	0	3	0	3	0	3	0	1	1	3	2	1	1	6	9			TCGA-CV-7254-01A-11D-2012-08	TCGA-CV-7254-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd22e861-571e-44da-82b6-b128e07d1963	137bf35f-72e9-46a3-a79c-251a58a698d5	g.chrX:139038574T>C	uc004fbb.2	-	3	589	c.567A>G	c.(565-567)GAA>GAG	p.E189E		NM_001013403	NP_001013421	Q5JRM2	CX066_HUMAN	hypothetical protein LOC347487 precursor	189	Cytoplasmic (Potential).					integral to membrane					0						TACATAATTTTTCTAGGCTGC	0.413													25	125					0	0	0	0	C	139038574	C	C	139038574	2	2	242	1	0	0	0	0	0	0	0	1	4135	1838	64	5		5	CXorf66	23	139038574	Silent	SNP	T	TCGA-CV-7254-01A-11D-2012-08	8630486	139038574	16231986	297	44668											
GLTPD1	80772	broad.mit.edu	37	chr1	1262354	1262354	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcagtttcaagcagtgtctcGatgagaaggaagaggtcttg	11	11	13	6	1	4	2	2	1	2	2	5	5	4	3	0	2	1	2	0	2	3	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:1262354G>A	uc001aeo.2	+	2	479	c.64G>A	c.(64-66)GAT>AAT	p.D22N	CPSF3L_uc001aee.1_5'Flank|CPSF3L_uc001aef.1_5'Flank|CPSF3L_uc009vjz.1_5'Flank|CPSF3L_uc010nyj.1_5'Flank|CPSF3L_uc001aeg.1_5'Flank|CPSF3L_uc001aeh.1_5'Flank|CPSF3L_uc001aei.1_5'Flank|CPSF3L_uc001aej.1_5'Flank|CPSF3L_uc001aek.1_5'Flank|CPSF3L_uc001aem.1_5'Flank|CPSF3L_uc001ael.1_5'Flank|CPSF3L_uc001aen.1_5'Flank	NM_001029885	NP_001025056	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	22						cytoplasm	glycolipid binding|glycolipid transporter activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GCAGTGTCTCGATGAGAAGGA	0.562													17	71					0	0	0	0	A	1262354	A	A	1262354	3	1	243	1	0	0	0	0	1	0	0	0	6509	1058	37	1	66	1	GLTPD1	1	1262354	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08		1262354	247988267	1	44669											
ZCCHC17	51538	broad.mit.edu	37	chr1	31837035	31837035	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agcacaagaagaagcacaagGagtgagagtataaagagtgt	19	5	13	4	0	0	4	0	1	0	4	0	6	0	5	0	1	2	3	0	1	7	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:31837035G>C	uc001bsp.1	+	8	857	c.721G>C	c.(721-723)GAG>CAG	p.E241Q	ZCCHC17_uc001bsq.1_Missense_Mutation_p.E233Q|ZCCHC17_uc010ogf.1_Missense_Mutation_p.E243Q|ZCCHC17_uc009vtu.1_Missense_Mutation_p.E217Q|ZCCHC17_uc001bsr.1_Missense_Mutation_p.E241Q|ZCCHC17_uc009vtv.1_Missense_Mutation_p.E217Q	NM_016505	NP_057589	Q9NP64	NO40_HUMAN	zinc finger, CCHC domain containing 17	241						nucleolus	RNA binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|all_neural(195;0.146)|Medulloblastoma(700;0.151)|Breast(348;0.222)		STAD - Stomach adenocarcinoma(196;0.0215)|READ - Rectum adenocarcinoma(331;0.168)		gaagcacaagGAGTGAGAGTA	0.383													14	28					0	0	0	0	C	31837035	C	C	31837035	3	2	243	1	0	0	0	0	1	0	0	0	17652	1175	41	2	747	2	ZCCHC17	1	31837035	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	30574681	31837035	217413586	2	44670											
CSMD2	114784	broad.mit.edu	37	chr1	34082539	34082539	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggagggtagttccatcgccGcactgttccgggcatgcagg	7	8	15	11	3	0	0	0	0	0	0	3	1	2	1	3	4	1	6	3	4	1	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:34082539G>C	uc001bxn.1	-	39	5892	c.5863C>G	c.(5863-5865)CGG>GGG	p.R1955G	CSMD2_uc001bxm.1_Missense_Mutation_p.R1995G|CSMD2_uc001bxo.1_Missense_Mutation_p.R868G	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1955	Sushi 11.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTCCATCGCCGCACTGTTCCG	0.527													17	88					0	0	0	0	C	34082539	C	C	34082539	3	2	243	1	0	0	0	0	1	0	0	0	3962	1086	38	3	4724	3	CSMD2	1	34082539	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	2245504	34082539	215168082	3	44671											
MACF1	23499	broad.mit.edu	37	chr1	39792914	39792914	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcagaaaaagagaagaaacaAatatctgagcaattgaatgc	21	7	8	5	0	2	5	1	2	1	3	2	6	2	5	0	0	3	1	0	0	8	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:39792914A>C	uc010ois.1	+	37	4723	c.4518A>C	c.(4516-4518)CAA>CAC	p.Q1506H	MACF1_uc001cda.1_Missense_Mutation_p.Q1414H|MACF1_uc001cdc.1_Missense_Mutation_p.Q593H|MACF1_uc001cdb.1_Missense_Mutation_p.Q593H	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAAGAAACAAATATCTGAGC	0.393													8	19					0	0	0	0	C	39792914	C	C	39792914	3	2	243	1	0	0	0	0	1	0	0	0	9195	11	1	5	4656	5	MACF1	1	39792914	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08	5710375	39792914	209457707	4	44672											
SLC2A1	6513	broad.mit.edu	37	chr1	43395563	43395564	+	Frame_Shift_Ins	INS	-	TCGT	TCGT																															cactcttggcccggttctccINStcgttgcggttgatgagcag																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:43395563_43395564insTCGT	uc001cik.2	-	5	1184_1185	c.659_660insACGA	c.(658-660)GAGfs	p.E220fs		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	220	Cytoplasmic (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CCCGGTTCTCCTCGTTGCGGTT	0.653													---	---	---								TCGT	43395564	TCGT	TCGT	43395563	7	5	243	1	0	1	1	0	0	0	0	0	14602	680	24	0	842	0	SLC2A1	1	43395563	Frame_Shift_Ins	INS	-	TCGA-CV-7255-01A-11D-2012-08	3602649	43395563	205855058	5	44673											
EBNA1BP2	10969	broad.mit.edu	37	chr1	43636551	43636551	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggcctgggcttggcgatagCtgagaatcgtaggacaaaat	11	8	14	8	3	0	1	0	1	0	1	1	4	0	2	1	4	1	3	1	4	5	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:43636551C>T	uc001cin.2	-	4	521	c.324_splice	c.e4-1	p.F108_splice	EBNA1BP2_uc001cio.2_Splice_Site_p.F163_splice|WDR65_uc010ojz.1_5'Flank|WDR65_uc001cip.1_5'Flank|WDR65_uc001ciq.1_5'Flank|EBNA1BP2_uc001cim.2_Splice_Site_p.F3_splice|EBNA1BP2_uc010ojx.1_Splice_Site_p.F163_splice	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2						ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTGGCGATAGCTGAGAATCGT	0.512													45	88					0	0	0	0	T	43636551	T	T	43636551	5	4	243	1	0	0	0	0	0	0	1	0	4907	811	28	4	621	4	EBNA1BP2	1	43636551	Splice_Site	SNP	C	TCGA-CV-7255-01A-11D-2012-08	240988	43636551	205614070	6	44674											
STIL	6491	broad.mit.edu	37	chr1	47726187	47726202	+	Frame_Shift_Del	DEL	TATTTAATAGGTGGTT	-	-																															ctcagtttccttggaggaacTatttaataggtggtttactt																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:47726187_47726202delTATTTAATAGGTGGTT	uc001crc.1	-	16	2991_3006	c.2836_2851delAACCACCTATTAAATA	c.(2836-2853)AACCACCTATTAAATAGTfs	p.N946fs	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Frame_Shift_Del_p.N900fs|STIL_uc010omo.1_Frame_Shift_Del_p.N929fs|STIL_uc001crd.1_Frame_Shift_Del_p.N947fs|STIL_uc001cre.1_Frame_Shift_Del_p.N946fs|STIL_uc001crf.1_Frame_Shift_Del_p.N559fs|STIL_uc001crg.1_Frame_Shift_Del_p.N882fs	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	946_951					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TTGGAGGAACTATTTAATAGGTGGTTTACTTGACCC	0.273													---	---	---								-	47726202	-	-	47726187	7	5	243	1	0	1	0	1	0	0	0	0	15348	1522	53	0	1020	0	STIL	1	47726187	Frame_Shift_Del	DEL	TATTTAATAGGTGGTT	TCGA-CV-7255-01A-11D-2012-08	4089636	47726187	201524434	7	44675											
DNTTIP2	30836	broad.mit.edu	37	chr1	94342296	94342296	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactgtggactcttcttcatCatcactaccaccacaatcac	12	11	3	15	0	6	0	4	0	2	0	6	1	6	1	2	1	2	0	2	1	3	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:94342296C>T	uc001dqf.2	-	2	1233	c.1195G>A	c.(1195-1197)GAT>AAT	p.D399N	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Missense_Mutation_p.D194N	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TCTTCTTCATCATCACTACCA	0.403													53	249					0	0	0	0	T	94342296	T	T	94342296	3	4	243	1	0	0	0	0	1	0	0	0	4704	826	29	2	1099	2	DNTTIP2	1	94342296	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	46616109	94342296	154908325	8	44676											
OVGP1	5016	broad.mit.edu	37	chr1	111969225	111969225	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agggcctggccgactgtgtgCccagttggtgaaataacaca	10	8	13	10	1	0	1	0	1	0	0	0	2	0	1	3	3	2	1	3	3	2	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:111969225C>A	uc001eba.2	-	3	150	c.94G>T	c.(94-96)GCA>TCA	p.A32S	OVGP1_uc001eaz.2_5'UTR|OVGP1_uc010owb.1_5'UTR|OVGP1_uc010owc.1_Missense_Mutation_p.A22S	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	32					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CGACTGTGTGCCCAGTTGGTG	0.532													9	28					9.70103e-10	1.27807e-09	1	0	A	111969225	A	A	111969225	3	1	243	1	0	0	0	0	1	0	0	0	11379	739	26	4	1978	4	OVGP1	1	111969225	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	17626929	111969225	137281396	9	44677											
TRIM45	80263	broad.mit.edu	37	chr1	117663359	117663359	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgagcctggcagcagaagtgGcagaggttggctttgcaggt	8	9	17	7	0	0	3	0	1	0	2	0	3	0	3	1	5	3	6	1	5	1	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:117663359G>A	uc001egz.2	-	1	1053	c.465C>T	c.(463-465)TGC>TGT	p.C155C	TRIM45_uc009whe.2_Silent_p.C155C|TRIM45_uc001eha.2_Silent_p.C51C	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	155	B box-type 1.					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		AGCAGAAGTGGCAGAGGTTGG	0.542													22	72					0	0	0	0	A	117663359	A	A	117663359	2	1	243	1	0	0	0	0	0	0	0	1	16587	1195	42	4		4	TRIM45	1	117663359	Silent	SNP	G	TCGA-CV-7255-01A-11D-2012-08	5694134	117663359	131587262	10	44678											
FLG	2312	broad.mit.edu	37	chr1	152277569	152277569	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcggtctgcagagtgccCgtgaccggctctgtcttcgt	4	10	15	12	4	3	2	0	1	3	1	4	3	3	3	2	3	3	2	2	3	0	1	rs144217264		TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:152277569C>T	uc001ezu.1	-	3	9829	c.9793G>A	c.(9793-9795)GGG>AGG	p.G3265R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3265	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCAGAGTGCCCGTGACCGGCT	0.582									Ichthyosis				219	333					0	0	0	0	T	152277569	T	T	152277569	3	4	243	1	0	0	0	0	1	0	0	0	5954	652	23	1	2396	1	FLG	1	152277569	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	34614210	152277569	96973052	11	44679											
C1orf182	128229	broad.mit.edu	37	chr1	156314481	156314481	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacttttctgaacatccagAcaacaaagctgccctcgggt	11	9	7	14	1	1	2	0	1	1	1	3	2	2	2	3	1	4	1	3	1	3	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:156314481A>T	uc001foo.2	+	3	507	c.145A>T	c.(145-147)ACA>TCA	p.T49S	C1orf182_uc009wry.2_Missense_Mutation_p.T49S|C1orf182_uc001fop.3_Missense_Mutation_p.T49S	NM_144627	NP_653228	Q96A04	CA182_HUMAN	SSTK-interacting protein	49											0	Hepatocellular(266;0.158)					GAACATCCAGACAACAAAGCT	0.507													20	131					0	0	0	0	T	156314481	T	T	156314481	3	4	243	1	0	0	0	0	1	0	0	0	2027	275	10	5	151	5	C1orf182	1	156314481	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08	4036912	156314481	92936140	12	44680											
TNN	63923	broad.mit.edu	37	chr1	175116091	175116091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaactgggagccttggaaaGgacatgaattctccattcct	11	11	10	9	0	1	2	0	2	1	0	3	5	2	5	3	3	2	0	3	3	3	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:175116091G>A	uc001gkl.1	+	19	3897	c.3784G>A	c.(3784-3786)GGA>AGA	p.G1262R		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1262	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCCTTGGAAAGGACATGAATT	0.507											OREG0013992	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	58					0	0	0	0	A	175116091	A	A	175116091	3	1	243	1	0	0	0	0	1	0	0	0	16389	1001	35	4	3854	4	TNN	1	175116091	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	18801610	175116091	74134530	13	44681											
SIPA1L2	57568	broad.mit.edu	37	chr1	232626732	232626733	+	Missense_Mutation	DNP	GG	AT	AT																															attccaaaacttctttgagaGgtagtcctcgtgcggtacca																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr1:232626732_232626733GG>AT	uc001hvg.2	-	3	1851_1852	c.1693_1694CC>AT	c.(1693-1695)CCT>ATT	p.P565I		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	565					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTCTTTGAGAGGTAGTCCTCGT	0.47													12	62					0	0	0	0	AT	232626733	AT	AT	232626732	3	1	243	1	0	0	0	0	1	0	0	0	14395	1000	35	4	3550	4	SIPA1L2	1	232626732	Missense_Mutation	DNP	GG	TCGA-CV-7255-01A-11D-2012-08	57510641	232626732	16623889	14	44682											
GREB1	9687	broad.mit.edu	37	chr2	11767141	11767141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgcggcgtcagacggcaCggatgagactgtccaagtac	10	7	14	10	4	1	2	1	1	0	2	2	4	2	3	1	3	2	2	1	3	2	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr2:11767141C>T	uc002rbk.1	+	25	4660	c.4360C>T	c.(4360-4362)CGG>TGG	p.R1454W	GREB1_uc002rbp.1_Missense_Mutation_p.R452W	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1454						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TCAGACGGCACGGATGAGACT	0.572													8	42					0	0	0	0	T	11767141	T	T	11767141	3	4	243	1	0	0	0	0	1	0	0	0	6799	527	19	1	4562	1	GREB1	2	11767141	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08		11767141	231432232	15	44683											
ATAD2B	54454	broad.mit.edu	37	chr2	24009046	24009046	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctgattctgataattgacGaggtggagaaggtagtgcaa	12	12	13	4	1	2	4	0	3	2	1	2	6	2	4	0	3	1	2	0	3	4	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr2:24009046G>A	uc002rek.3	-	21	3118	c.2824C>T	c.(2824-2826)CGT>TGT	p.R942C	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Missense_Mutation_p.R187C|ATAD2B_uc002rej.3_Missense_Mutation_p.R110C	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	942							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATAATTGACGAGGTGGAGAA	0.453													3	8					0	0	0	0	A	24009046	A	A	24009046	3	1	243	1	0	0	0	0	1	0	0	0	1074	1058	37	1	1584	1	ATAD2B	2	24009046	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	12241905	24009046	219190327	16	44684											
CLEC4F	165530	broad.mit.edu	37	chr2	71044191	71044202	+	In_Frame_Del	DEL	TAAATGTCTGGA	-	-																															ggaattctccatgtggccttTaaatgtctggataagctctc																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr2:71044191_71044202delTAAATGTCTGGA	uc002shf.2	-	4	388_399	c.311_322delTCCAGACATTTA	c.(310-324)ATCCAGACATTTAAA>AAA	p.IQTF104del	CLEC4F_uc010yqv.1_In_Frame_Del_p.IQTF104del	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	104_107	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						ATGTGGCCTTTAAATGTCTGGATAAGCTCTCG	0.491													---	---	---								-	71044202	-	-	71044191	7	5	243	1	0	1	0	1	0	0	0	0	3531	1763	61	0	1463	0	CLEC4F	2	71044191	In_Frame_Del	DEL	TAAATGTCTGGA	TCGA-CV-7255-01A-11D-2012-08	47035145	71044191	172155182	17	44685											
LRP2	4036	broad.mit.edu	37	chr2	170055331	170055331	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcatcactgttatctccaCagtcattgtctccgtcacac	8	15	4	14	1	6	0	4	0	2	0	8	0	6	0	2	0	0	1	2	0	1	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr2:170055331C>T	uc002ues.2	-	45	8756	c.8543G>A	c.(8542-8544)TGT>TAT	p.C2848Y		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2848	LDL-receptor class A 19.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTTATCTCCACAGTCATTGTC	0.378													8	20					0	0	0	0	T	170055331	T	T	170055331	3	4	243	1	0	0	0	0	1	0	0	0	9006	478	17	4	5564	4	LRP2	2	170055331	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	99011140	170055331	73144042	18	44686											
MYO3B	140469	broad.mit.edu	37	chr2	171055899	171055899	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaaattctggatccagtcAgtgtaagtaacagttgtaaa	15	12	9	5	0	2	1	1	1	1	0	3	2	3	2	1	1	1	4	1	1	6	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr2:171055899A>T	uc002ufy.2	+	2	327	c.184A>T	c.(184-186)AGT>TGT	p.S62C	MYO3B_uc002ufv.2_Missense_Mutation_p.S49C|MYO3B_uc010fqb.1_Missense_Mutation_p.S49C|MYO3B_uc002ufz.2_Missense_Mutation_p.S62C|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002uga.2_Missense_Mutation_p.S49C	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	62	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GGATCCAGTCAGTGTAAGTAA	0.363													3	14					0	0	0	0	T	171055899	T	T	171055899	3	4	243	1	0	0	0	0	1	0	0	0	10130	188	7	5	190	5	MYO3B	2	171055899	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08	1000568	171055899	72143474	19	44687											
TTN	7273	broad.mit.edu	37	chr2	179569648	179569648	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aataaatgatacaagttcctCaaattccttttcgtccctct	12	15	3	11	1	2	1	1	1	1	0	6	1	5	1	3	0	1	1	3	0	6	6			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr2:179569648C>G	uc010zfg.1	-	101	26142	c.25918G>C	c.(25918-25920)GAG>CAG	p.E8640Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E5301Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9567							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAAGTTCCTCAAATTCCTTT	0.308													33	95					0	0	0	0	G	179569648	G	G	179569648	3	3	243	1	0	0	0	0	1	0	0	0	16803	835	29	2	74915	2	TTN	2	179569648	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	8513749	179569648	63629725	20	44688											
TTN	7273	broad.mit.edu	37	chr2	179595244	179595244	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgccaacctttgactgtcaGatgcccactgcattggttgt	7	14	9	11	0	1	2	1	1	0	1	1	2	1	2	3	1	4	2	3	1	1	4			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr2:179595244G>T	uc010zfg.1	-	58	14508	c.14284C>A	c.(14284-14286)CTG>ATG	p.L4762M	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.L1423M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5689							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGACTGTCAGATGCCCACTG	0.378													29	86					1.22384e-17	1.65168e-17	1	0	T	179595244	T	T	179595244	3	4	243	1	0	0	0	0	1	0	0	0	16803	933	33	2	86721	2	TTN	2	179595244	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	25596	179595244	63604129	21	44689											
ITGAV	3685	broad.mit.edu	37	chr2	187506226	187506226	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagcttcaggagacttccAgacgacaaagctgaatggat	14	7	12	8	1	1	4	1	1	0	3	2	8	2	5	1	2	2	2	1	2	2	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr2:187506226A>T	uc002upq.2	+	12	1346	c.1070A>T	c.(1069-1071)CAG>CTG	p.Q357L	ITGAV_uc010frs.2_Missense_Mutation_p.Q321L|ITGAV_uc010zfv.1_Missense_Mutation_p.Q311L	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	357	FG-GAP 5.|Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GGAGACTTCCAGACGACAAAG	0.493													52	141					0	0	0	0	T	187506226	T	T	187506226	3	4	243	1	0	0	0	0	1	0	0	0	7927	188	7	5	1167	5	ITGAV	2	187506226	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08	7910982	187506226	55693147	22	44690											
DUSP28	285193	broad.mit.edu	37	chr2	241500794	241500794	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaaccgaacccgggcttctgGtctcagctccagaagtatga	10	8	11	12	2	2	2	1	1	2	1	4	4	3	2	3	2	3	3	3	2	4	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr2:241500794G>T	uc002vzg.2	+	2	1072	c.441G>T	c.(439-441)TGG>TGT	p.W147C	ANKMY1_uc002vzd.1_5'Flank|ANKMY1_uc010fze.1_5'Flank|ANKMY1_uc002vze.2_5'Flank|ANKMY1_uc002vzf.2_5'Flank|DUSP28_uc002vzh.2_Missense_Mutation_p.W147C	NM_001033575	NP_001028747	Q4G0W2	DUS28_HUMAN	dual specificity phosphatase 28	147							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-31)|all cancers(36;5.56e-29)|OV - Ovarian serous cystadenocarcinoma(60;7.57e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.06e-06)|Lung(119;0.00164)|Colorectal(34;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.00802)|COAD - Colon adenocarcinoma(134;0.0311)		CGGGCTTCTGGTCTCAGCTCC	0.602													14	45					3.27435e-08	4.1811e-08	1	0	T	241500794	T	T	241500794	3	4	243	1	0	0	0	0	1	0	0	0	4847	1270	44	4	447	4	DUSP28	2	241500794	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	53994568	241500794	1698579	23	44691											
DPPA2	151871	broad.mit.edu	37	chr3	109027049	109027049	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgctctctcattcatctcaTaacttctctgaagccttgct	7	16	4	14	0	5	1	3	1	3	0	8	1	5	1	1	0	4	2	1	0	2	4			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr3:109027049T>C	uc003dxo.2	-	6	735	c.488A>G	c.(487-489)TAT>TGT	p.Y163C		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	163						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						ATTCATCTCATAACTTCTCTG	0.468													19	71					0	0	0	0	C	109027049	C	C	109027049	3	2	243	1	0	0	0	0	1	0	0	0	4756	1406	49	5	420	5	DPPA2	3	109027049	Missense_Mutation	SNP	T	TCGA-CV-7255-01A-11D-2012-08		109027049	88995381	24	44692											
WDR49	151790	broad.mit.edu	37	chr3	167223119	167223119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatttttttataacttcacCataataaggtttttgtgttt	10	22	5	4	0	1	1	1	1	0	0	1	1	1	1	1	1	1	2	1	1	4	11			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr3:167223119C>T	uc003fev.1	-	13	2110	c.1804G>A	c.(1804-1806)GGT>AGT	p.G602S	WDR49_uc003feu.1_Missense_Mutation_p.G427S|WDR49_uc011bpd.1_Missense_Mutation_p.G567S|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	602										large_intestine(1)|ovary(1)|skin(1)	3						ATAACTTCACCATAATAAGGT	0.259													4	24					0	0	0	0	T	167223119	T	T	167223119	3	4	243	1	0	0	0	0	1	0	0	0	17370	594	21	4	301	4	WDR49	3	167223119	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	58196070	167223119	30799311	25	44693											
KIAA1530	57654	broad.mit.edu	37	chr4	1360207	1360207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacacatccccgaccacttgCggcctgagtatggtgagcag	9	7	11	14	2	0	2	0	2	0	0	1	3	1	2	4	2	2	2	4	2	1	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr4:1360207C>T	uc003gde.3	+	8	1723	c.1276C>T	c.(1276-1278)CGG>TGG	p.R426W	KIAA1530_uc010ibv.2_5'UTR	NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	426											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			CGACCACTTGCGGCCTGAGTA	0.642													57	156					0	0	0	0	T	1360207	T	T	1360207	3	4	243	1	0	0	0	0	1	0	0	0	8280	759	27	1	1302	1	KIAA1530	4	1360207	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08		1360207	189794069	26	44694											
HTT	3064	broad.mit.edu	37	chr4	3131671	3131672	+	Missense_Mutation	DNP	CC	AG	AG																															gtgttagacggtaccgacaaCcagtatttgggcctgcagat																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr4:3131671_3131672CC>AG	uc011bvq.1	+	14	1915_1916	c.1770_1771CC>AG	c.(1768-1773)AACCAG>AAAGAG	p.590_591NQ>KE		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	588_589					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GTACCGACAACCAGTATTTGGG	0.505													11	145					0	0	0	0	AG	3131672	AG	AG	3131671	3	1	243	1	0	0	0	0	1	0	0	0	7496	506	18	4	1814	4	HTT	4	3131671	Missense_Mutation	DNP	CC	TCGA-CV-7255-01A-11D-2012-08	1771464	3131671	188022605	27	44695											
SORCS2	57537	broad.mit.edu	37	chr4	7735048	7735048	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcccctctgtgcttgcaGaggctcgccgccatccagca	5	9	10	17	2	1	1	0	0	1	1	4	1	3	1	5	1	3	4	5	1	0	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr4:7735048G>A	uc003gkb.3	+	24	3109	c.3109_splice	c.e24-1	p.R1037_splice	SORCS2_uc011bwi.1_Splice_Site_p.R865_splice	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor							integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						TGTGCTTGCAGAGGCTCGCCG	0.652													2	2					0	0	0	0	A	7735048	A	A	7735048	5	1	243	1	0	0	0	0	0	0	1	0	14995	956	33	2	3202	2	SORCS2	4	7735048	Splice_Site	SNP	G	TCGA-CV-7255-01A-11D-2012-08	4603377	7735048	183419228	28	44696											
ZNF827	152485	broad.mit.edu	37	chr4	146824264	146824264	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagacaacttatagttctcCtggacttccccataggatgc	11	11	8	11	0	1	1	0	0	1	1	3	4	2	3	3	2	2	1	3	2	4	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr4:146824264C>T	uc003ikn.2	-	2	195	c.147G>A	c.(145-147)CAG>CAA	p.Q49Q	ZNF827_uc003ikm.2_Silent_p.Q49Q|ZNF827_uc010iox.2_Intron	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	49					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					TATAGTTCTCCTGGACTTCCC	0.562													29	78					0	0	0	0	T	146824264	T	T	146824264	2	4	243	1	0	0	0	0	0	0	0	1	18247	680	24	4		4	ZNF827	4	146824264	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	139089216	146824264	44330012	29	44697											
MYO10	4651	broad.mit.edu	37	chr5	16701457	16701457	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgccacttgttcgctggtctGagtggccgtgctcgctgggg	2	12	16	11	3	1	1	0	1	1	0	3	1	1	1	2	4	2	4	2	4	0	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr5:16701457G>C	uc003jft.3	-	25	3515	c.3047C>G	c.(3046-3048)TCA>TGA	p.S1016*	MYO10_uc011cnc.1_5'Flank|MYO10_uc011cnd.1_Nonsense_Mutation_p.S373*|MYO10_uc011cne.1_Nonsense_Mutation_p.S373*|MYO10_uc010itx.2_Nonsense_Mutation_p.S639*	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1016					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TCGCTGGTCTGAGTGGCCGTG	0.627													13	34					0	0	0	0	C	16701457	C	C	16701457	4	2	243	1	0	0	0	0	0	1	0	0	10115	1294	45	2	3197	2	MYO10	5	16701457	Nonsense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08		16701457	164213803	30	44698											
C6	729	broad.mit.edu	37	chr5	41159257	41159257	+	Frame_Shift_Del	DEL	G	-	-																															acagcgtttccctcctcgttGgggggcaggattattgcatt																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr5:41159257delG	uc003jmk.2	-	12	1993	c.1783delC	c.(1783-1785)CAAfs	p.Q595fs	C6_uc003jml.1_Frame_Shift_Del_p.Q595fs	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	595	TSP type-1 3.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CCTCCTCGTTGGGGGGCAGGA	0.498													---	---	---								-	41159257	-	-	41159257	7	5	243	1	0	1	0	1	0	0	0	0	2325	1357	47	0	1049	0	C6	5	41159257	Frame_Shift_Del	DEL	G	TCGA-CV-7255-01A-11D-2012-08	24457800	41159257	139756003	31	44699											
SLCO6A1	133482	broad.mit.edu	37	chr5	101834432	101834432	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcccgggcttcgaggacttCggggttcccttggccctcct	2	12	12	15	3	0	0	0	0	0	0	5	2	3	1	4	5	0	2	4	5	0	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr5:101834432C>T	uc003knn.2	-	1	289	c.117G>A	c.(115-117)CCG>CCA	p.P39P	SLCO6A1_uc003kno.2_Silent_p.P39P|SLCO6A1_uc003knp.2_Silent_p.P39P|SLCO6A1_uc003knq.2_Silent_p.P39P	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	39	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TCGAGGACTTCGGGGTTCCCT	0.592													104	57					0	0	0	0	T	101834432	T	T	101834432	2	4	243	1	0	0	0	0	0	0	0	1	14796	871	31	1		1	SLCO6A1	5	101834432	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	60675175	101834432	79080828	32	44700											
IL9	3578	broad.mit.edu	37	chr5	135231263	135231263	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattagcactgcagtggcacTtggaagctggatcttcctaa	10	11	10	10	0	1	0	0	0	1	0	2	2	2	2	1	3	3	4	1	3	3	4			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr5:135231263T>G	uc003lbb.1	-	2	142	c.131A>C	c.(130-132)AAG>ACG	p.K44T		NM_000590	NP_000581	P15248	IL9_HUMAN	interleukin 9 precursor	44					immune response|inflammatory response|positive regulation of cell proliferation|positive regulation of interleukin-5 biosynthetic process	extracellular space	cytokine activity|cytokine receptor binding|growth factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCAGTGGCACTTGGAAGCTGG	0.378													18	79					0	0	0	0	G	135231263	G	G	135231263	3	3	243	1	0	0	0	0	1	0	0	0	7746	1609	56	5	319	5	IL9	5	135231263	Missense_Mutation	SNP	T	TCGA-CV-7255-01A-11D-2012-08	33396831	135231263	45683997	33	44701											
KDM3B	51780	broad.mit.edu	37	chr5	137727094	137727097	+	Frame_Shift_Del	DEL	GAAA	-	-																															gctggcagctctgtggaccgGaaagtgcctgcagagtccat																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr5:137727094_137727097delGAAA	uc003lcy.1	+	8	1973_1976	c.1773_1776delGAAA	c.(1771-1776)CGGAAAfs	p.R591fs	KDM3B_uc010jew.1_Frame_Shift_Del_p.R247fs|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	591_592					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						CTGTGGACCGGAAAGTGCCTGCAG	0.544													---	---	---								-	137727097	-	-	137727094	7	5	243	1	0	1	0	1	0	0	0	0	8166	1161	41	0	1803	0	KDM3B	5	137727094	Frame_Shift_Del	DEL	GAAA	TCGA-CV-7255-01A-11D-2012-08	2495831	137727094	43188166	34	44702											
GRIA1	2890	broad.mit.edu	37	chr5	153026582	153026582	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttttgtggggccctccaCgtctgcttcattacgccgag	4	13	10	14	3	2	0	1	0	1	0	4	1	4	0	4	2	2	1	4	2	1	4	rs138090704		TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr5:153026582C>T	uc003lva.3	+	3	680	c.315C>T	c.(313-315)CAC>CAT	p.H105H	GRIA1_uc003luy.3_Silent_p.H105H|GRIA1_uc003luz.3_Silent_p.H10H|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Silent_p.H36H|GRIA1_uc011dcy.1_Silent_p.H115H|GRIA1_uc011dcz.1_Silent_p.H115H|GRIA1_uc010jia.1_Silent_p.H85H	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	105	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGGCCCTCCACGTCTGCTTCA	0.502													47	55					0	0	0	0	T	153026582	T	T	153026582	2	4	243	1	0	0	0	0	0	0	0	1	6806	535	19	1		1	GRIA1	5	153026582	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	15299488	153026582	27888678	35	44703											
IL12B	3593	broad.mit.edu	37	chr5	158749490	158749490	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccagaataattcttggcctCgcatcttagaaaggtcttat	11	14	7	9	1	3	2	0	0	3	2	5	2	4	2	2	2	0	1	2	2	5	5	rs139186048		TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr5:158749490C>T	uc003lxr.1	-	4	436	c.394G>A	c.(394-396)GAG>AAG	p.E132K		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	132					cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCTTGGCCTCGCATCTTAGA	0.378													14	40					0	0	0	0	T	158749490	T	T	158749490	3	4	243	1	0	0	0	0	1	0	0	0	7664	893	31	1	608	1	IL12B	5	158749490	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	5722908	158749490	22165770	36	44704											
UNC5A	90249	broad.mit.edu	37	chr5	176301345	176301345	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcagtctctgtccccggcagGatgggcccagccccaagttc	6	7	12	16	1	1	0	0	0	1	0	4	1	2	1	5	3	1	3	5	3	1	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr5:176301345G>T	uc003mey.2	+	8	1348	c.1156G>T	c.(1156-1158)GAT>TAT	p.D386Y	UNC5A_uc010jkg.1_Missense_Mutation_p.D346Y	NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	386	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCCCGGCAGGATGGGCCCAG	0.647													39	158					1.36161e-19	1.85269e-19	1	0	T	176301345	T	T	176301345	3	4	243	1	0	0	0	0	1	0	0	0	17059	1174	41	2	1186	2	UNC5A	5	176301345	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	17551855	176301345	4613915	37	44705											
HIST1H2AB	8335	broad.mit.edu	37	chr6	26033684	26033685	+	Missense_Mutation	DNP	CC	AA	AA																															cgacgcgctcggagtagttgCctttgcggagcaggcggtgc																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr6:26033684_26033685CC>AA	uc003nft.1	-	1	112_113	c.112_113GG>TT	c.(112-114)GGC>TTC	p.G38F	HIST1H3B_uc003nfs.1_5'Flank	NM_003513	NP_003504	P04908	H2A1B_HUMAN	histone cluster 1, H2ab	38				GN -> AH (in Ref. 1; CAA24951).	nucleosome assembly	nucleosome|nucleus	DNA binding				0						GGAGTAGTTGCCTTTGCGGAGC	0.653													14	93					0	0	0	0	AA	26033685	AA	AA	26033684	3	1	243	1	0	0	0	0	1	0	0	0	7168	739	26	4	283	4	HIST1H2AB	6	26033684	Missense_Mutation	DNP	CC	TCGA-CV-7255-01A-11D-2012-08		26033684	145081383	38	44706											
HIST1H4I	8294	broad.mit.edu	37	chr6	27107126	27107126	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaggtaagggcctggggaaAgggggtgccaagcgccaccg	9	3	20	9	2	0	0	0	0	0	0	0	2	0	2	4	7	2	1	4	7	3	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr6:27107126A>C	uc003niy.1	+	1	39	c.39A>C	c.(37-39)AAA>AAC	p.K13N	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	13					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						GCCTGGGGAAAGGGGGTGCCA	0.597			T	BCL6	NHL								19	51					0	0	0	0	C	27107126	C	C	27107126	3	2	243	1	0	0	0	0	1	0	0	0	7212	69	3	5	41	5	HIST1H4I	6	27107126	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08	1073442	27107126	144007941	39	44707											
HLA-B	3106	broad.mit.edu	37	chr6	31323330	31323330	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcagggtggcctcatggTcagagatggggtggtgggtc	6	9	18	8	0	3	1	3	0	0	1	4	2	3	1	2	7	0	0	2	7	0	0			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr6:31323330T>G	uc003nth.2	-	4	713	c.659A>C	c.(658-660)GAC>GCC	p.D220A	HLA-C_uc003ntb.2_RNA|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_RNA|HLA-B_uc011dnk.1_RNA|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Missense_Mutation_p.D99A|HLA-B_uc003nti.1_RNA|HLA-B_uc010jsn.1_RNA|HLA-B_uc010jso.2_3'UTR	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	220	Alpha-3.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						GGCCTCATGGTCAGAGATGGG	0.582									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				27	175					0	0	0	0	G	31323330	G	G	31323330	3	3	243	1	0	0	0	0	1	0	0	0	7235	1667	58	5	445	5	HLA-B	6	31323330	Missense_Mutation	SNP	T	TCGA-CV-7255-01A-11D-2012-08	4216204	31323330	139791737	40	44708											
AGPAT1	10554	broad.mit.edu	37	chr6	32138309	32138309	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccagcaggccagcccggCagagccagcccacagtagct	10	2	12	17	1	0	1	0	0	0	1	0	1	0	1	5	2	6	4	5	2	1	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr6:32138309C>T	uc003oae.2	-	4	721	c.403G>A	c.(403-405)GCC>ACC	p.A135T	PPT2_uc003nzy.1_RNA|AGPAT1_uc011dpj.1_RNA|AGPAT1_uc011dpk.1_Missense_Mutation_p.A99T|AGPAT1_uc003oaf.2_Missense_Mutation_p.A135T|AGPAT1_uc003oag.2_Intron|AGPAT1_uc003oah.2_Missense_Mutation_p.A135T|AGPAT1_uc003oai.1_Missense_Mutation_p.A135T|AGPAT1_uc011dpl.1_Missense_Mutation_p.A23T	NM_006411	NP_006402	Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	135	Helical; (Potential).				energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)	1						GCCAGCCCGGCAGAGCCAGCC	0.652													15	107					0	0	0	0	T	32138309	T	T	32138309	3	4	243	1	0	0	0	0	1	0	0	0	386	710	25	4	464	4	AGPAT1	6	32138309	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	814979	32138309	138976758	41	44709											
AGER	177	broad.mit.edu	37	chr6	32150719	32150720	+	Missense_Mutation	DNP	GC	TT	TT																															gacggggatctcctccccggGctggggtcaccattagctcc																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr6:32150719_32150720GC>TT	uc003oal.1	-	6	613_614	c.589_590GC>AA	c.(589-591)GCC>AAC	p.A197N	AGER_uc003oak.1_5'Flank|AGER_uc003oar.2_Missense_Mutation_p.A96N|AGER_uc011dpm.1_Missense_Mutation_p.A96N|AGER_uc011dpn.1_Missense_Mutation_p.A96N|AGER_uc010jtv.1_Missense_Mutation_p.A197N|AGER_uc011dpo.1_Missense_Mutation_p.A110N|AGER_uc003oam.1_Intron|AGER_uc003oan.1_Missense_Mutation_p.A183N|AGER_uc003oap.1_Missense_Mutation_p.A213N|AGER_uc003oat.1_Missense_Mutation_p.A213N|AGER_uc003oao.1_RNA|AGER_uc003oaq.1_Missense_Mutation_p.A183N|AGER_uc010jtw.1_RNA|AGER_uc003oas.1_Missense_Mutation_p.A197N|AGER_uc003oau.1_Missense_Mutation_p.A197N|AGER_uc011dpp.1_Missense_Mutation_p.A197N|AGER_uc011dpq.1_Missense_Mutation_p.A213N	NM_001136	NP_001127	Q15109	RAGE_HUMAN	advanced glycosylation end product-specific	197	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response|neuron projection development|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	S100 alpha binding|transmembrane receptor activity			breast(1)	1						TCCTCCCCGGGCTGGGGTCACC	0.619													11	94					0	0	0	0	TT	32150720	TT	TT	32150719	3	4	243	1	0	0	0	0	1	0	0	0	379	1203	42	4	677	4	AGER	6	32150719	Missense_Mutation	DNP	GC	TCGA-CV-7255-01A-11D-2012-08	12410	32150719	138964348	42	44710	93	2									
AGER	177	broad.mit.edu	37	chr6	32150723	32150723	+	Missense_Mutation	SNP	G	C	C																															gggatctcctccccgggctgGggtcaccattagctccgact																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr6:32150723G>C	uc003oal.1	-	6	610	c.586C>G	c.(586-588)CCA>GCA	p.P196A	AGER_uc003oak.1_5'Flank|AGER_uc003oar.2_Missense_Mutation_p.P95A|AGER_uc011dpm.1_Missense_Mutation_p.P95A|AGER_uc011dpn.1_Missense_Mutation_p.P95A|AGER_uc010jtv.1_Missense_Mutation_p.P196A|AGER_uc011dpo.1_Missense_Mutation_p.P109A|AGER_uc003oam.1_Intron|AGER_uc003oan.1_Missense_Mutation_p.P182A|AGER_uc003oap.1_Missense_Mutation_p.P212A|AGER_uc003oat.1_Missense_Mutation_p.P212A|AGER_uc003oao.1_RNA|AGER_uc003oaq.1_Missense_Mutation_p.P182A|AGER_uc010jtw.1_RNA|AGER_uc003oas.1_Missense_Mutation_p.P196A|AGER_uc003oau.1_Missense_Mutation_p.P196A|AGER_uc011dpp.1_Missense_Mutation_p.P196A|AGER_uc011dpq.1_Missense_Mutation_p.P212A	NM_001136	NP_001127	Q15109	RAGE_HUMAN	advanced glycosylation end product-specific	196	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response|neuron projection development|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	S100 alpha binding|transmembrane receptor activity			breast(1)	1						CCCCGGGCTGGGGTCACCATT	0.607													10	94					0	0	0	0	C	32150723	C	C	32150723	3	2	243	1	0	0	0	0	1	0	0	0	379	1232	43	4	681	4	AGER	6	32150723	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	4	32150723	138964344	43	44711	93	2									
LAMA4	3910	broad.mit.edu	37	chr6	112537594	112537594	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtatcctgagccgtccaaaCactcgttggaattgccatta	11	11	8	11	2	0	1	0	1	0	0	3	2	2	2	4	1	3	2	4	1	4	4			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr6:112537594C>A	uc003pvu.2	-	3	581	c.272G>T	c.(271-273)TGT>TTT	p.C91F	LAMA4_uc003pvv.2_Missense_Mutation_p.C91F|LAMA4_uc003pvt.2_Missense_Mutation_p.C91F|LAMA4_uc003pvw.2_Missense_Mutation_p.C91F	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	91	Laminin EGF-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GCCGTCCAAACACTCGTTGGA	0.458													8	56					7.48243e-07	9.33897e-07	1	0	A	112537594	A	A	112537594	3	1	243	1	0	0	0	0	1	0	0	0	8648	478	17	4	5347	4	LAMA4	6	112537594	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	80386871	112537594	58577473	44	44712											
RFX6	222546	broad.mit.edu	37	chr6	117250042	117250042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacagtgacatccacgatcCacttaacattttagatgaca	14	11	5	11	1	0	3	0	2	0	1	2	4	2	3	2	0	2	0	2	0	3	4			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr6:117250042C>T	uc003pxm.2	+	18	2582	c.2519C>T	c.(2518-2520)CCA>CTA	p.P840L		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	840					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						ATCCACGATCCACTTAACATT	0.463													24	99					0	0	0	0	T	117250042	T	T	117250042	3	4	243	1	0	0	0	0	1	0	0	0	13332	594	21	4	2589	4	RFX6	6	117250042	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	4712448	117250042	53865025	45	44713											
GPER	2852	broad.mit.edu	37	chr7	1132135	1132135	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggccccggcggcagaaggcGctccgcatgatcctcgcggt	5	5	15	16	7	0	2	0	1	0	1	3	2	2	2	4	5	0	3	4	5	1	0			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr7:1132135G>A	uc010ksd.1	+	2	1160	c.771G>A	c.(769-771)GCG>GCA	p.A257A	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPER_uc003sjz.1_Silent_p.A257A|GPER_uc003ska.1_Silent_p.A257A|GPER_uc003skb.2_Silent_p.A257A	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	257	Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		GGCAGAAGGCGCTCCGCATGA	0.682													26	59					0	0	0	0	A	1132135	A	A	1132135	2	1	243	1	0	0	0	0	0	0	0	1	6645	1074	38	1		1	GPER	7	1132135	Silent	SNP	G	TCGA-CV-7255-01A-11D-2012-08		1132135	158006528	46	44714											
FKBP14	55033	broad.mit.edu	37	chr7	30058665	30058665	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccatttcttggaatgattCatgggatcttggtccatttc	8	17	8	8	0	3	1	1	1	2	0	6	3	5	3	2	3	0	0	2	3	1	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr7:30058665C>A	uc003tal.1	-	3	568	c.424G>T	c.(424-426)GAA>TAA	p.E142*	FKBP14_uc010kvq.1_RNA	NM_017946	NP_060416	Q9NWM8	FKB14_HUMAN	FK506 binding protein 14 precursor	142	EF-hand 1.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						TGGAATGATTCATGGGATCTT	0.393													15	69					6.31663e-08	8.00428e-08	1	0	A	30058665	A	A	30058665	4	1	243	1	0	0	0	0	0	1	0	0	5936	835	29	2	219	2	FKBP14	7	30058665	Nonsense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	28926530	30058665	129079998	47	44715											
GTF2IRD2	84163	broad.mit.edu	37	chr7	74211326	74211327	+	Frame_Shift_Ins	INS	-	T	T																															agtcagttcgctttcgtagaINSgtttgaaatcagacagcctt																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr7:74211326_74211327insT	uc003ubd.1	-	16	2708_2709	c.2524_2525insA	c.(2524-2526)CTCfs	p.L842fs	GTF2IRD2_uc010lbt.1_Frame_Shift_Ins_p.L389fs	NM_173537	NP_775808	Q86UP8	GTD2A_HUMAN	GTF2I repeat domain containing 2	842					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						gctttcgtagagtttgaaatca	0													---	---	---								T	74211327	T	T	74211326	7	5	243	1	0	1	1	0	0	0	0	0	6908	304	11	0	328	0	GTF2IRD2	7	74211326	Frame_Shift_Ins	INS	-	TCGA-CV-7255-01A-11D-2012-08	44152661	74211326	84927337	48	44716											
PPP1R9A	55607	broad.mit.edu	37	chr7	94827740	94827740	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacactggaacaggagaggCgccagagagagctgctggaa	14	3	16	8	1	0	4	0	0	0	4	0	8	0	6	1	4	3	2	1	4	2	0			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr7:94827740C>T	uc003unp.2	+	6	2116	c.1834C>T	c.(1834-1836)CGC>TGC	p.R612C	PPP1R9A_uc010lfj.2_Missense_Mutation_p.R612C|PPP1R9A_uc011kif.1_Missense_Mutation_p.R612C|PPP1R9A_uc003unq.2_Missense_Mutation_p.R612C|PPP1R9A_uc011kig.1_Missense_Mutation_p.R612C	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	612	Potential.|Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			ACAGGAGAGGCGCCAGAGAGA	0.448										HNSCC(28;0.073)			23	126					0	0	0	0	T	94827740	T	T	94827740	3	4	243	1	0	0	0	0	1	0	0	0	12438	768	27	1	1852	1	PPP1R9A	7	94827740	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	20616414	94827740	64310923	49	44717											
TFR2	7036	broad.mit.edu	37	chr7	100238307	100238307	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatggggcagggccatccctAcctgatggtgtcctccaggc	6	8	14	13	0	0	1	0	1	0	0	3	2	3	1	5	5	1	1	5	5	1	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr7:100238307A>G	uc003uvv.1	-	3	514	c.473_splice	c.e3+1	p.R158_splice	TFR2_uc003uvw.1_Nonstop_Mutation_p.*159Q	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2						cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GGCCATCCCTACCTGATGGTG	0.657													5	17					0	0	0	0	G	100238307	G	G	100238307	5	3	243	1	0	0	0	0	0	0	1	0	15877	405	14	5	1994	5	TFR2	7	100238307	Splice_Site	SNP	A	TCGA-CV-7255-01A-11D-2012-08	5410567	100238307	58900356	50	44718											
TNPO3	23534	broad.mit.edu	37	chr7	128640537	128640537	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agctccagagttcgaaggtcCccaagaccttggcctggagt	9	8	12	12	1	0	2	0	0	0	2	3	4	2	3	5	3	1	2	5	3	2	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr7:128640537C>T	uc003vol.1	-	7	1331	c.957G>A	c.(955-957)GGG>GGA	p.G319G	TNPO3_uc003vom.1_Silent_p.G253G|TNPO3_uc010lly.1_Silent_p.G319G|TNPO3_uc010llz.1_Silent_p.G319G	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	319					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						TTCGAAGGTCCCCAAGACCTT	0.433													16	76					0	0	0	0	T	128640537	T	T	128640537	2	4	243	1	0	0	0	0	0	0	0	1	16403	610	22	4		4	TNPO3	7	128640537	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	28402230	128640537	30498126	51	44719											
ZNF425	155054	broad.mit.edu	37	chr7	148802572	148802572	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taataaaatctttctctcttTccctcgtaaggcagcacaca	12	13	4	12	1	3	0	0	0	3	0	6	0	4	0	1	1	1	3	1	1	4	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr7:148802572T>C	uc003wfj.2	-	4	464	c.391A>G	c.(391-393)AAA>GAA	p.K131E		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	131					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TTTCTCTCTTTCCCTCGTAAG	0.428													3	84					0	0	0	0	C	148802572	C	C	148802572	3	2	243	1	0	0	0	0	1	0	0	0	17966	1792	62	5	1871	5	ZNF425	7	148802572	Missense_Mutation	SNP	T	TCGA-CV-7255-01A-11D-2012-08	20162035	148802572	10336091	52	44720											
LYN	4067	broad.mit.edu	37	chr8	56860268	56860268	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaagaaaggagagaagatGaaagtcctggaggagtaagt	17	7	14	3	0	1	4	1	1	0	3	2	8	2	7	1	3	0	1	1	3	5	2	rs149135061		TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr8:56860268G>A	uc003xsk.3	+	4	552	c.270G>A	c.(268-270)ATG>ATA	p.M90I	LYN_uc003xsl.3_Missense_Mutation_p.M69I	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	90	SH3.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			GAGAGAAGATGAAAGTCCTGG	0.527													20	101					0	0	0	0	A	56860268	A	A	56860268	3	1	243	1	0	0	0	0	1	0	0	0	9158	1290	45	2	280	2	LYN	8	56860268	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08		56860268	89503754	53	44721											
MRPS28	28957	broad.mit.edu	37	chr8	80915385	80915385	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagaatgtctcagcatagAtgcaaaggattccacatttt	14	11	9	7	0	1	2	1	0	1	2	3	4	2	3	1	2	2	2	1	2	3	4			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr8:80915385A>G	uc003ybp.2	-	2	267	c.244T>C	c.(244-246)TCT>CCT	p.S82P	MRPS28_uc003ybo.2_5'UTR|TPD52_uc010lzr.2_RNA	NM_014018	NP_054737	Q9Y2Q9	RT28_HUMAN	mitochondrial ribosomal protein S28	82						mitochondrial small ribosomal subunit					0	Lung NSC(7;1.86e-06)|all_lung(9;6.91e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00769)|Epithelial(68;0.0208)|all cancers(69;0.0805)			CTCAGCATAGATGCAAAGGAT	0.338													8	37					0	0	0	0	G	80915385	G	G	80915385	3	3	243	1	0	0	0	0	1	0	0	0	9892	333	12	5	327	5	MRPS28	8	80915385	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08	24055117	80915385	65448637	54	44722											
SLC26A7	115111	broad.mit.edu	37	chr8	92352728	92352728	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctatgtggcctcactggcTcttgctcaaggatctgccaa	7	11	11	12	0	4	0	2	0	2	0	4	1	4	1	2	4	2	3	2	4	3	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr8:92352728T>C	uc003yex.2	+	9	1253	c.975T>C	c.(973-975)GCT>GCC	p.A325A	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Silent_p.A325A|SLC26A7_uc003yfa.2_Silent_p.A325A	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	325	Helical; (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CCTCACTGGCTCTTGCTCAAG	0.502													21	106					0	0	0	0	C	92352728	C	C	92352728	2	2	243	1	0	0	0	0	0	0	0	1	14586	1538	54	5		5	SLC26A7	8	92352728	Silent	SNP	T	TCGA-CV-7255-01A-11D-2012-08	11437343	92352728	54011294	55	44723											
VPS13B	157680	broad.mit.edu	37	chr8	100871564	100871572	+	In_Frame_Del	DEL	AGCCCTGCA	-	-																															ggtctctggatattcttggcAgccctgcaagcctggtgaga																								rs61754107	byFrequency	TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr8:100871564_100871572delAGCCCTGCA	uc003yiv.2	+	57	11086_11094	c.10975_10983delAGCCCTGCA	c.(10975-10983)AGCCCTGCAdel	p.SPA3659del	VPS13B_uc003yiw.2_In_Frame_Del_p.SPA3634del	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3659_3661					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TATTCTTGGCAGCCCTGCAAGCCTGGTGA	0.56													---	---	---								-	100871572	-	-	100871564	7	5	243	1	0	1	0	1	0	0	0	0	17258	188	7	0	11391	0	VPS13B	8	100871564	In_Frame_Del	DEL	AGCCCTGCA	TCGA-CV-7255-01A-11D-2012-08	8518836	100871564	45492458	56	44724											
CSMD3	114788	broad.mit.edu	37	chr8	113249437	113249437	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgaaagtagcagctccaTgttgctattgctcagtgttg	9	13	10	9	0	1	1	1	1	0	0	2	1	2	1	2	0	4	7	2	0	3	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr8:113249437T>C	uc003ynu.2	-	67	10768	c.10609A>G	c.(10609-10611)ATG>GTG	p.M3537V	CSMD3_uc003yns.2_Missense_Mutation_p.M2739V|CSMD3_uc003ynt.2_Missense_Mutation_p.M3497V|CSMD3_uc011lhx.1_Missense_Mutation_p.M3368V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3537	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGCAGCTCCATGTTGCTATTG	0.358										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	126					0	0	0	0	C	113249437	C	C	113249437	3	2	243	1	0	0	0	0	1	0	0	0	3963	1464	51	5	534	5	CSMD3	8	113249437	Missense_Mutation	SNP	T	TCGA-CV-7255-01A-11D-2012-08	12377873	113249437	33114585	57	44725											
CSMD3	114788	broad.mit.edu	37	chr8	113347673	113347673	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtattgccactgaactgaccGatctgaggtgaattttggtc	9	13	11	8	1	1	4	0	4	1	0	2	5	1	4	2	2	2	1	2	2	3	4	rs142588028		TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr8:113347673G>A	uc003ynu.2	-	45	7209	c.7050C>T	c.(7048-7050)ATC>ATT	p.I2350I	CSMD3_uc003yns.2_Silent_p.I1552I|CSMD3_uc003ynt.2_Silent_p.I2310I|CSMD3_uc011lhx.1_Silent_p.I2246I|CSMD3_uc003ynw.1_Silent_p.I61I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2350	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGAACTGACCGATCTGAGGTG	0.403										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			33	13					0	0	0	0	A	113347673	A	A	113347673	2	1	243	1	0	0	0	0	0	0	0	1	3963	1048	37	1		1	CSMD3	8	113347673	Silent	SNP	G	TCGA-CV-7255-01A-11D-2012-08	98236	113347673	33016349	58	44726											
CDKN2A	1029	broad.mit.edu	37	chr9	21968234	21968234	+	Frame_Shift_Del	DEL	G	-	-																															cctctctggttctttcaatcGgggatgtctgcagagggcag																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr9:21968234delG	uc003zpk.2	-	3	677	c.465delC	c.(463-465)CCCfs	p.P155fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	155					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(4)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCTTTCAATCGGGGATGTCTG	0.557		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---								-	21968234	-	-	21968234	7	5	243	1	0	1	0	1	0	0	0	0	3176	1103	39	0	9	0	CDKN2A	9	21968234	Frame_Shift_Del	DEL	G	TCGA-CV-7255-01A-11D-2012-08		21968234	119245197	59	44727											
PCSK5	5125	broad.mit.edu	37	chr9	78796390	78796390	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagtgtgcccccaactgtGagtcctgctttgggagccat	7	10	13	11	0	0	1	0	1	0	0	1	3	1	3	4	2	4	1	4	2	2	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr9:78796390G>A	uc004ajz.2	+	16	2618	c.2080G>A	c.(2080-2082)GAG>AAG	p.E694K	PCSK5_uc004aka.2_RNA|PCSK5_uc004akb.2_5'UTR	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	694	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						CCCCAACTGTGAGTCCTGCTT	0.517													15	49					0	0	0	0	A	78796390	A	A	78796390	3	1	243	1	0	0	0	0	1	0	0	0	11657	1291	45	2	2142	2	PCSK5	9	78796390	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	56828156	78796390	62417041	60	44728											
CRB2	286204	broad.mit.edu	37	chr9	126125359	126125359	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccgggtttccagggcccaCgctgcgagctggacatcgat	6	8	14	13	4	0	0	0	0	0	0	2	3	1	1	3	3	3	3	3	3	0	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr9:126125359C>T	uc004bnx.1	+	2	402	c.310C>T	c.(310-312)CGC>TGC	p.R104C	CRB2_uc004bnw.1_Missense_Mutation_p.R104C	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	104	Extracellular (Potential).|EGF-like 1.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CCAGGGCCCACGCTGCGAGCT	0.682													8	39					0	0	0	0	T	126125359	T	T	126125359	3	4	243	1	0	0	0	0	1	0	0	0	3864	536	19	1	316	1	CRB2	9	126125359	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	47328969	126125359	15088072	61	44729											
FAM102A	399665	broad.mit.edu	37	chr9	130712724	130712724	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaggatggagttgtcctggCgagtgttcttcgtgtcatat	7	15	13	6	2	2	0	1	0	1	0	4	3	3	2	1	3	0	2	1	3	2	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr9:130712724C>T	uc004bsx.1	-	4	471	c.392G>A	c.(391-393)CGC>CAC	p.R131H	FAM102A_uc004bsw.1_5'UTR|FAM102A_uc004bsy.1_5'Flank	NM_001035254	NP_001030331	Q5T9C2	F102A_HUMAN	early estrogen-induced gene 1 protein isoform a	131										ovary(1)	1						GTTGTCCTGGCGAGTGTTCTT	0.602													19	102					0	0	0	0	T	130712724	T	T	130712724	3	4	243	1	0	0	0	0	1	0	0	0	5410	768	27	1	794	1	FAM102A	9	130712724	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	4587365	130712724	10500707	62	44730											
COL13A1	1305	broad.mit.edu	37	chr10	71677072	71677072	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggcatgccagggatgccaGgcaagcatggagccaaggta	11	4	17	9	0	0	0	0	0	0	0	0	2	0	2	3	6	4	4	3	6	3	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr10:71677072G>T	uc001jpr.1	+	17	1515	c.979G>T	c.(979-981)GGC>TGC	p.G327C	COL13A1_uc001jqj.1_Missense_Mutation_p.G327C|COL13A1_uc001jps.1_Missense_Mutation_p.G298C|COL13A1_uc001jpt.1_Missense_Mutation_p.G286C|COL13A1_uc001jpu.1_Missense_Mutation_p.G308C|COL13A1_uc001jpv.1_Missense_Mutation_p.G327C|COL13A1_uc001jpx.1_Missense_Mutation_p.G305C|COL13A1_uc001jpw.1_Missense_Mutation_p.G274C|COL13A1_uc001jpy.1_Missense_Mutation_p.G265C|COL13A1_uc001jpz.1_Missense_Mutation_p.G270C|COL13A1_uc001jqa.1_Missense_Mutation_p.G267C|COL13A1_uc001jqc.1_Missense_Mutation_p.G327C|COL13A1_uc001jqb.1_Missense_Mutation_p.G276C|COL13A1_uc001jql.2_Missense_Mutation_p.G327C|COL13A1_uc001jqd.1_Missense_Mutation_p.G315C|COL13A1_uc001jqe.1_Missense_Mutation_p.G310C|COL13A1_uc001jqf.1_Missense_Mutation_p.G308C|COL13A1_uc001jqg.1_Missense_Mutation_p.G305C|COL13A1_uc001jqh.1_Missense_Mutation_p.G327C|COL13A1_uc001jqi.1_Missense_Mutation_p.G327C|COL13A1_uc010qjf.1_Missense_Mutation_p.G117C|COL13A1_uc001jqk.1_Missense_Mutation_p.G165C	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	327	Extracellular (Potential).|Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	AGGGATGCCAGGCAAGCATGG	0.632													11	22					2.27111e-07	2.85609e-07	1	0	T	71677072	T	T	71677072	3	4	243	1	0	0	0	0	1	0	0	0	3685	1000	35	4	1049	4	COL13A1	10	71677072	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08		71677072	63857675	63	44731											
FAM178A	55719	broad.mit.edu	37	chr10	102706839	102706839	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaatgaactctccagtcatcCccacaacctcctgtggttgg	10	10	7	14	0	2	1	1	1	1	0	5	1	4	1	5	2	2	1	5	2	3	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr10:102706839C>T	uc001krt.3	+	14	3520	c.2978C>T	c.(2977-2979)CCC>CTC	p.P993L	FAM178A_uc001krs.2_Missense_Mutation_p.P993L	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	993											0						TCCAGTCATCCCCACAACCTC	0.363													26	85					0	0	0	0	T	102706839	T	T	102706839	3	4	243	1	0	0	0	0	1	0	0	0	5531	623	22	4	3032	4	FAM178A	10	102706839	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	31029767	102706839	32827908	64	44732											
PDZD7	79955	broad.mit.edu	37	chr10	102777943	102777943	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcccgtcccgcgctagccTcccctgccgccctcccttga	2	7	9	23	5	0	1	0	1	0	0	3	1	3	1	8	0	2	1	8	0	1	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr10:102777943T>C	uc001kso.1	-	9	1650	c.1435A>G	c.(1435-1437)AGG>GGG	p.R479G	PDZD7_uc001ksn.2_Missense_Mutation_p.R479G	NM_024895	NP_079171	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	479						cilium|nucleus	protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		CGCGCTAGCCTCCCCTGCCGC	0.637													21	60					0	0	0	0	C	102777943	C	C	102777943	3	2	243	1	0	0	0	0	1	0	0	0	11758	1550	54	5	126	5	PDZD7	10	102777943	Missense_Mutation	SNP	T	TCGA-CV-7255-01A-11D-2012-08	71104	102777943	32756804	65	44733											
MUC5B	727897	broad.mit.edu	37	chr11	1264977	1264977	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagccacggccacacccagCaagacccgcacctcgaccct	11	2	7	21	3	0	1	0	0	0	1	1	2	0	1	6	1	2	2	6	1	1	0			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:1264977C>T	uc009ycr.1	+	48	8907	c.8781C>T	c.(8779-8781)AGC>AGT	p.S2927S	MUC5B_uc001ltb.2_Silent_p.S2292S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2289	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACACCCAGCAAGACCCGCA	0.677													22	95					0	0	0	0	T	1264977	T	T	1264977	2	4	243	1	0	0	0	0	0	0	0	1	10032	709	25	4		4	MUC5B	11	1264977	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08		1264977	133741539	66	44734											
MUC5B	727897	broad.mit.edu	37	chr11	1268748	1268748	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagccacagccacacccagCaagacccgcacctcgaccct	12	2	6	21	2	0	1	0	0	0	1	1	2	0	1	6	0	3	2	6	0	1	0			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:1268748C>T	uc009ycr.1	+	50	12348	c.12222C>T	c.(12220-12222)AGC>AGT	p.S4074S	MUC5B_uc001ltb.2_Silent_p.S3549S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3546	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACACCCAGCAAGACCCGCA	0.682													5	187					0	0	0	0	T	1268748	T	T	1268748	2	4	243	1	0	0	0	0	0	0	0	1	10032	709	25	4		4	MUC5B	11	1268748	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	3771	1268748	133737768	67	44735											
TRIM5	85363	broad.mit.edu	37	chr11	5699621	5699621	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggatgtctctcagttgcTcaaaatctgccaagacgttg	10	11	9	11	1	4	1	2	0	2	1	5	2	4	2	2	1	2	3	2	1	3	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:5699621T>C	uc001mbm.1	-	4	814	c.557A>G	c.(556-558)GAG>GGG	p.E186G	TRIM5_uc001mbq.1_Missense_Mutation_p.E186G|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Missense_Mutation_p.E186G|TRIM5_uc001mbo.2_Missense_Mutation_p.E186G|TRIM5_uc001mbp.2_Missense_Mutation_p.E186G	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	186	Potential.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		TCTCAGTTGCTCAAAATCTGC	0.468													3	138					0	0	0	0	C	5699621	C	C	5699621	3	2	243	1	0	0	0	0	1	0	0	0	16592	1551	54	5	1183	5	TRIM5	11	5699621	Missense_Mutation	SNP	T	TCGA-CV-7255-01A-11D-2012-08	4430873	5699621	129306895	68	44736											
DNHD1	144132	broad.mit.edu	37	chr11	6588483	6588483	+	Frame_Shift_Del	DEL	C	-	-																															gcaattgagagcacacctgaCccgccagctgctgggcagca																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:6588483delC	uc001mdw.3	+	36	12308	c.11744delC	c.(11743-11745)ACCfs	p.T3915fs	DNHD1_uc001mea.3_Frame_Shift_Del_p.T184fs|DNHD1_uc001meb.2_Frame_Shift_Del_p.T183fs|DNHD1_uc001mec.2_Frame_Shift_Del_p.T183fs|DNHD1_uc010rao.1_Frame_Shift_Del_p.T173fs|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	3915					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GCACACCTGACCCGCCAGCTG	0.587													---	---	---								-	6588483	-	-	6588483	7	5	243	1	0	1	0	1	0	0	0	0	4690	507	18	0	11887	0	DNHD1	11	6588483	Frame_Shift_Del	DEL	C	TCGA-CV-7255-01A-11D-2012-08	888862	6588483	128418033	69	44737											
MS4A14	84689	broad.mit.edu	37	chr11	60183510	60183510	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgacagctaatgacctgcccCctcaaggcatactatcccaa	12	8	6	15	0	1	2	1	2	0	0	2	2	2	2	4	1	3	2	4	1	5	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:60183510C>T	uc001npj.2	+	5	1634	c.1069C>T	c.(1069-1071)CCT>TCT	p.P357S	MS4A14_uc001npi.2_Missense_Mutation_p.P245S|MS4A14_uc001npn.2_Missense_Mutation_p.P95S|MS4A14_uc001npk.2_Missense_Mutation_p.P340S|MS4A14_uc001npl.2_Missense_Mutation_p.P95S|MS4A14_uc001npm.2_Missense_Mutation_p.P95S	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	357						integral to membrane	receptor activity			breast(1)	1						TGACCTGCCCCCTCAAGGcat	0.254													13	27					0	0	0	0	T	60183510	T	T	60183510	3	4	243	1	0	0	0	0	1	0	0	0	9911	623	22	4	1087	4	MS4A14	11	60183510	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	53595027	60183510	74823006	70	44738											
CFL1	1072	broad.mit.edu	37	chr11	65623524	65623524	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaaggtggcgtaggggtcgtCgacagtctggcccacatcgc	8	7	15	11	4	1	0	0	0	1	0	4	1	1	0	1	5	0	1	1	5	2	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:65623524C>T	uc001ofs.2	-	2	427	c.193G>A	c.(193-195)GAC>AAC	p.D65N	CFL1_uc001oft.2_Missense_Mutation_p.D65N|CFL1_uc001ofu.2_3'UTR	NM_005507	NP_005498	P23528	COF1_HUMAN	cofilin 1 (non-muscle)	65	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding				0				READ - Rectum adenocarcinoma(159;0.169)		TAGGGGTCGTCGACAGTCTGG	0.562													51	71					0	0	0	0	T	65623524	T	T	65623524	3	4	243	1	0	0	0	0	1	0	0	0	3305	884	31	1	319	1	CFL1	11	65623524	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	5440014	65623524	69382992	71	44739											
SPTBN2	6712	broad.mit.edu	37	chr11	66454940	66454940	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcctccatctcctgcttgCggcacagcatcccctccatc	6	9	7	19	1	1	0	0	0	1	0	6	0	4	0	6	2	3	3	6	2	0	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:66454940C>T	uc001ojd.2	-	34	6752	c.6680G>A	c.(6679-6681)CGC>CAC	p.R2227H	SPTBN2_uc001ojc.1_Missense_Mutation_p.A88T	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	2227	PH.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CTCCTGCTTGCGGCACAGCAT	0.642													44	73					0	0	0	0	T	66454940	T	T	66454940	3	4	243	1	0	0	0	0	1	0	0	0	15186	768	27	1	508	1	SPTBN2	11	66454940	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	831416	66454940	68551576	72	44740											
PPME1	51400	broad.mit.edu	37	chr11	73962725	73962725	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gttgccactttcctgatccgGcacaggtttgcagaacccat	8	11	9	13	1	0	2	0	1	0	1	2	2	2	2	4	2	3	4	4	2	1	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:73962725G>A	uc001ouw.2	+	13	1206	c.1107G>A	c.(1105-1107)CGG>CGA	p.R369R	PPME1_uc009yty.2_Silent_p.R253R|PPME1_uc001oux.2_Silent_p.R182R|P4HA3_uc001ouy.3_Intron	NM_016147	NP_057231	Q9Y570	PPME1_HUMAN	protein phosphatase methylesterase 1	369					protein demethylation		carboxylesterase activity|protein C-terminal methylesterase activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0	Breast(11;3.29e-05)					TCCTGATCCGGCACAGGTTTG	0.522													5	127					0	0	0	0	A	73962725	A	A	73962725	2	1	243	1	0	0	0	0	0	0	0	1	12407	1190	42	4		4	PPME1	11	73962725	Silent	SNP	G	TCGA-CV-7255-01A-11D-2012-08	7507785	73962725	61043791	73	44741											
TYR	7299	broad.mit.edu	37	chr11	88911070	88911070	+	Translation_Start_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtagctggaaagagaaatCtgtgactccaattagccagt	14	10	10	7	0	1	2	0	1	1	1	2	4	2	3	2	1	2	2	2	1	6	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:88911070C>G	uc001pcs.2	+	1	31	c.-51C>G	c.(-53--49)ATCTG>ATGTG			NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor						eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	AAAGAGAAATCTGTGACTCCA	0.458									Oculocutaneous_Albinism				14	23					0	0	0	0	G	88911070	G	G	88911070	1	3	243	1	0	0	0	0	0	0	0	0	16881	928	32	2		2	TYR	11	88911070	Translation_Start_Site	SNP	C	TCGA-CV-7255-01A-11D-2012-08	14948345	88911070	46095446	74	44742											
GRIA4	2893	broad.mit.edu	37	chr11	105758286	105758286	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttaaaggctaccattatatCattgcaaacttggtaagaac	15	12	7	7	0	1	1	1	0	0	1	1	1	1	1	1	2	4	4	1	2	8	7			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:105758286C>A	uc001pix.2	+	6	1160	c.714C>A	c.(712-714)ATC>ATA	p.I238I	GRIA4_uc001piu.1_Silent_p.I238I|GRIA4_uc001piw.2_Silent_p.I238I|GRIA4_uc009yxk.1_Silent_p.I238I	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	238	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ACCATTATATCATTGCAAACT	0.269													6	61					0.000157383	0.000190698	1	0	A	105758286	A	A	105758286	2	1	243	1	0	0	0	0	0	0	0	1	6809	816	29	2		2	GRIA4	11	105758286	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	16847216	105758286	29248230	75	44743											
OR8B12	219858	broad.mit.edu	37	chr11	124413461	124413461	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaccgtgtagaaacccagAaacaggaagaagagggggat	16	4	15	6	1	0	5	0	1	0	4	0	7	0	7	2	3	2	1	2	3	5	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr11:124413461A>T	uc010sam.1	-	1	90	c.90T>A	c.(88-90)TTT>TTA	p.F30L		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		AGAAACCCAGAAACAGGAAGA	0.512													22	72					0	0	0	0	T	124413461	T	T	124413461	3	4	243	1	0	0	0	0	1	0	0	0	11280	243	9	5	844	5	OR8B12	11	124413461	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08	18655175	124413461	10593055	76	44744											
OR6C4	341418	broad.mit.edu	37	chr12	55945874	55945874	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttactgaatcccttcatataTactttaagaaatcagcaagt	15	14	4	8	0	2	2	2	1	0	1	3	2	3	2	1	0	3	1	1	0	8	7			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr12:55945874T>C	uc010spp.1	+	1	864	c.864T>C	c.(862-864)TAT>TAC	p.Y288Y		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTTCATATATACTTTAAGAA	0.333													13	34					0	0	0	0	C	55945874	C	C	55945874	2	2	243	1	0	0	0	0	0	0	0	1	11247	1413	49	5		5	OR6C4	12	55945874	Silent	SNP	T	TCGA-CV-7255-01A-11D-2012-08		55945874	77906021	77	44745											
ACSS3	79611	broad.mit.edu	37	chr12	81472045	81472045	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcggggcggtctcgggggccGgggatgcagggcactgtcct	3	6	21	11	4	1	0	0	0	1	0	3	1	2	1	2	8	1	2	2	8	0	0			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr12:81472045G>A	uc001szl.1	+	1	237	c.146G>A	c.(145-147)CGG>CAG	p.R49Q	ACSS3_uc001szm.1_Missense_Mutation_p.R49Q	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	49						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CTCGGGGGCCGGGGATGCAGG	0.731													12	14					0	0	0	0	A	81472045	A	A	81472045	3	1	243	1	0	0	0	0	1	0	0	0	190	1116	39	1	148	1	ACSS3	12	81472045	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	25526171	81472045	52379850	78	44746											
ANKLE2	23141	broad.mit.edu	37	chr12	133331319	133331319	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatagtacaggggcggctcCttagacgcagtcgctccagc	8	7	12	14	3	0	1	0	0	0	1	3	1	2	1	3	3	2	4	3	3	3	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr12:133331319C>T	uc001ukx.2	-	2	649	c.582G>A	c.(580-582)AAG>AAA	p.K194K	ANKLE2_uc001uky.3_Silent_p.K132K	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	194						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		GGGGCGGCTCCTTAGACGCAG	0.567													17	58					0	0	0	0	T	133331319	T	T	133331319	2	4	243	1	0	0	0	0	0	0	0	1	633	680	24	4		4	ANKLE2	12	133331319	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	51859274	133331319	520576	79	44747											
FREM2	341640	broad.mit.edu	37	chr13	39265893	39265893	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgcgaggtcacctggaatGcacggatcagcctggtgtgt	8	9	14	10	2	2	0	2	0	0	0	2	3	2	2	2	4	3	1	2	4	1	0			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr13:39265893G>T	uc001uwv.2	+	1	4721	c.4412G>T	c.(4411-4413)TGC>TTC	p.C1471F		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1471	Extracellular (Potential).|CSPG 10.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CACCTGGAATGCACGGATCAG	0.468													13	39					0.00010058	0.000122767	1	0	T	39265893	T	T	39265893	3	4	243	1	0	0	0	0	1	0	0	0	6079	1319	46	4	4414	4	FREM2	13	39265893	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08		39265893	75903985	80	44748											
TSC22D1	8848	broad.mit.edu	37	chr13	45149170	45149170	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcccaacactcacaccAgcagcactaggaatattgct	13	6	7	15	0	1	0	1	0	0	0	1	1	1	1	3	2	4	3	3	2	4	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr13:45149170A>G	uc001uzn.3	-	1	1532	c.1041T>C	c.(1039-1041)GCT>GCC	p.A347A	TSC22D1_uc001uzo.1_Silent_p.A347A	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	347					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		CACTCACACCAGCAGCACTAG	0.413													17	53					0	0	0	0	G	45149170	G	G	45149170	2	3	243	1	0	0	0	0	0	0	0	1	16674	175	7	5		5	TSC22D1	13	45149170	Silent	SNP	A	TCGA-CV-7255-01A-11D-2012-08	5883277	45149170	70020708	81	44749											
OR4M1	441670	broad.mit.edu	37	chr14	20249046	20249046	+	Frame_Shift_Del	DEL	T	-	-																															cacaggttgtccggattgccTgtgccaacaccttcccagag																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr14:20249046delT	uc010tku.1	+	1	565	c.565delT	c.(565-567)TGTfs	p.C189fs		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCGGATTGCCTGTGCCAACAC	0.458													---	---	---								-	20249046	-	-	20249046	7	5	243	1	0	1	0	1	0	0	0	0	11129	1580	55	0	567	0	OR4M1	14	20249046	Frame_Shift_Del	DEL	T	TCGA-CV-7255-01A-11D-2012-08		20249046	87100494	82	44750											
CHD8	57680	broad.mit.edu	37	chr14	21897487	21897487	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaccagggtgatgcgtttcGattcaccctaaagtgaagaa	12	9	12	8	2	1	3	1	2	0	1	2	5	1	4	2	2	1	1	2	2	4	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr14:21897487G>A	uc001was.1	-	3	108	c.14C>T	c.(13-15)TCG>TTG	p.S5L	CHD8_uc001war.1_5'UTR	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	284					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GATGCGTTTCGATTCACCCTA	0.438													12	38					0	0	0	0	A	21897487	A	A	21897487	3	1	243	1	0	0	0	0	1	0	0	0	3346	1059	37	1	7038	1	CHD8	14	21897487	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	1648441	21897487	85452053	83	44751											
OTX2	5015	broad.mit.edu	37	chr14	57268457	57268457	+	Frame_Shift_Del	DEL	A	-	-																															gaggttctacaggtcttcacAaaacctggaatttccacgag																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr14:57268457delA	uc001xcp.2	-	3	1037	c.866delT	c.(865-867)TTGfs	p.L289fs	OTX2_uc010aou.2_Frame_Shift_Del_p.L289fs|OTX2_uc001xcq.2_Frame_Shift_Del_p.L297fs	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	289					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					AGGTCTTCACAAAACCTGGAA	0.408													---	---	---								-	57268457	-	-	57268457	7	5	243	1	0	1	0	1	0	0	0	0	11375	131	5	0	7	0	OTX2	14	57268457	Frame_Shift_Del	DEL	A	TCGA-CV-7255-01A-11D-2012-08	35370970	57268457	50081083	84	44752											
EXD2	55218	broad.mit.edu	37	chr14	69697274	69697274	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgacaagtcccttctacttCgttgcagcaactgggatgct	8	13	9	11	1	1	1	0	1	1	0	3	2	2	2	1	1	5	4	1	1	3	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr14:69697274C>T	uc001xkt.2	+	6	960	c.301C>T	c.(301-303)CGT>TGT	p.R101C	EXD2_uc001xku.2_5'UTR|EXD2_uc001xkv.2_Missense_Mutation_p.R226C|EXD2_uc001xkw.2_Missense_Mutation_p.R101C|EXD2_uc001xkx.2_RNA|EXD2_uc010aqt.2_Missense_Mutation_p.R226C|EXD2_uc010tte.1_Missense_Mutation_p.R226C|EXD2_uc001xky.2_Missense_Mutation_p.R101C	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	101	3'-5' exonuclease.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						CCTTCTACTTCGTTGCAGCAA	0.408													16	81					0	0	0	0	T	69697274	T	T	69697274	3	4	243	1	0	0	0	0	1	0	0	0	5322	884	31	1	307	1	EXD2	14	69697274	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	12428817	69697274	37652266	85	44753											
COQ6	51004	broad.mit.edu	37	chr14	74426168	74426168	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacgtcccatgaacatgcAgcagagctagttagcatgga	12	8	10	11	1	0	2	0	1	0	1	2	3	2	3	2	1	5	5	2	1	3	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr14:74426168A>C	uc001xph.2	+	8	914	c.834A>C	c.(832-834)GCA>GCC	p.A278A	ENTPD5_uc001xpi.2_3'UTR|COQ6_uc001xpe.2_Silent_p.A203A|COQ6_uc001xpf.2_Silent_p.A203A|COQ6_uc010tuk.1_Silent_p.A253A|COQ6_uc010tun.1_3'UTR|COQ6_uc001xpg.2_Silent_p.A278A	NM_182476	NP_872282	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 homolog isoform a	278					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.00337)		ATGAACATGCAGCAGAGCTAG	0.483													18	110					0	0	0	0	C	74426168	C	C	74426168	2	2	243	1	0	0	0	0	0	0	0	1	3764	175	7	5		5	COQ6	14	74426168	Silent	SNP	A	TCGA-CV-7255-01A-11D-2012-08	4728894	74426168	32923372	86	44754											
C15orf2	23742	broad.mit.edu	37	chr15	24922410	24922410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctaactctcctctggctcttCctgctgaccttgttcccatt	4	16	5	16	0	3	1	0	1	3	0	6	1	5	1	4	1	2	3	4	1	1	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr15:24922410C>T	uc001ywo.2	+	1	1870	c.1396C>T	c.(1396-1398)CCT>TCT	p.P466S		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	466	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TCTGGCTCTTCCTGCTGACCT	0.498													44	158					0	0	0	0	T	24922410	T	T	24922410	3	4	243	1	0	0	0	0	1	0	0	0	1790	855	30	2	1398	2	C15orf2	15	24922410	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08		24922410	77608982	87	44755											
TMEM62	80021	broad.mit.edu	37	chr15	43446919	43446919	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctgtcacagttaagattGatggagttcatttaggccag	10	14	10	7	0	3	2	2	1	1	1	3	3	3	3	1	2	0	2	1	2	2	6			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr15:43446919G>C	uc001zqr.2	+	9	1351	c.1072G>C	c.(1072-1074)GAT>CAT	p.D358H	TMEM62_uc010bda.2_Missense_Mutation_p.D228H	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	358						integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		AGTTAAGATTGATGGAGTTCA	0.388													4	33					0	0	0	0	C	43446919	C	C	43446919	3	2	243	1	0	0	0	0	1	0	0	0	16255	1290	45	2	1106	2	TMEM62	15	43446919	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	18524509	43446919	59084473	88	44756											
ACSM5	54988	broad.mit.edu	37	chr16	20442600	20442600	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaggggaatgttgccgtccGtatcagacccactcggccct	8	8	12	13	3	1	2	1	0	0	2	3	3	2	3	4	3	1	2	4	3	2	2	rs144464842	by1000genomes	TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr16:20442600G>A	uc002dhe.2	+	10	1412	c.1265G>A	c.(1264-1266)CGT>CAT	p.R422H		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	422					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						GTTGCCGTCCGTATCAGACCC	0.453													36	214					0	0	0	0	A	20442600	A	A	20442600	3	1	243	1	0	0	0	0	1	0	0	0	187	1145	40	1	1299	1	ACSM5	16	20442600	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08		20442600	69912153	89	44757											
SCNN1G	6340	broad.mit.edu	37	chr16	23221114	23221114	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctacagtcagtgcacggAggacgggagtgacgtgccaa	10	5	15	11	3	1	1	1	1	0	0	1	4	1	4	2	3	3	1	2	3	2	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr16:23221114A>G	uc002dlm.1	+	7	1260	c.1121A>G	c.(1120-1122)GAG>GGG	p.E374G		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	374	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	CAGTGCACGGAGGACGGGAGT	0.617													9	76					0	0	0	0	G	23221114	G	G	23221114	3	3	243	1	0	0	0	0	1	0	0	0	13995	304	11	5	1143	5	SCNN1G	16	23221114	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08	2778514	23221114	67133639	90	44758											
C16orf53	79447	broad.mit.edu	37	chr16	29828566	29828566	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatttgattttgatgatgAgccagtgacaccaaaggact	13	11	11	6	0	0	5	0	5	0	0	0	7	0	7	2	2	1	0	2	2	2	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr16:29828566A>G	uc002dug.3	+	2	837	c.518A>G	c.(517-519)GAG>GGG	p.E173G	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron	NM_024516	NP_078792	Q9BTK6	PA1_HUMAN	PTIP-associated 1 protein	173											0						TTTGATGATGAGCCAGTGACA	0.557											OREG0023722	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	42					0	0	0	0	G	29828566	G	G	29828566	3	3	243	1	0	0	0	0	1	0	0	0	1824	304	11	5	524	5	C16orf53	16	29828566	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08	6607452	29828566	60526187	91	44759											
MMP15	4324	broad.mit.edu	37	chr16	58077474	58077475	+	Frame_Shift_Ins	INS	-	G	G																															tgggtaccccaagcccatcaINSgtgtctggcaggggatccct																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr16:58077474_58077475insG	uc002ena.2	+	9	2486_2487	c.1513_1514insG	c.(1513-1515)AGTfs	p.S505fs		NM_002428	NP_002419	P51511	MMP15_HUMAN	matrix metalloproteinase 15 preproprotein	505	Hemopexin-like 3.|Extracellular (Potential).				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			central_nervous_system(2)|breast(1)	3						CAAGCCCATCAGTGTCTGGCAG	0.599													---	---	---								G	58077475	G	G	58077474	7	5	243	1	0	1	1	0	0	0	0	0	9707	188	7	0	1547	0	MMP15	16	58077474	Frame_Shift_Ins	INS	-	TCGA-CV-7255-01A-11D-2012-08	28248908	58077474	32277279	92	44760											
DPEP1	1800	broad.mit.edu	37	chr16	89702704	89702704	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacacgccctgcgacacccaGaacaaagacgccgtgcggag	12	3	11	15	5	0	2	0	0	0	2	0	4	0	3	3	1	4	0	3	1	3	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr16:89702704G>A	uc010cin.2	+	4	473	c.270G>A	c.(268-270)CAG>CAA	p.Q90Q	DPEP1_uc002fnr.3_Silent_p.Q90Q|DPEP1_uc002fns.3_Silent_p.Q90Q	NM_001128141	NP_001121613	P16444	DPEP1_HUMAN	dipeptidase 1 precursor	90					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(1)	1		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	GCGACACCCAGAACAAAGACG	0.652													9	24					0	0	0	0	A	89702704	A	A	89702704	2	1	243	1	0	0	0	0	0	0	0	1	4735	933	33	2		2	DPEP1	16	89702704	Silent	SNP	G	TCGA-CV-7255-01A-11D-2012-08	31625230	89702704	652049	93	44761											
SERPINF1	5176	broad.mit.edu	37	chr17	1675260	1675260	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaccctcgcttggacctgcaAgagatcaacaactgggtgca	12	7	10	12	1	1	1	1	0	0	1	2	3	1	2	2	2	5	3	2	2	4	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr17:1675260A>T	uc002ftl.2	+	5	691	c.534A>T	c.(532-534)CAA>CAT	p.Q178H	SERPINF1_uc010cjw.2_Translation_Start_Site	NM_002615	NP_002606	P36955	PEDF_HUMAN	serine (or cysteine) proteinase inhibitor, clade	178					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			ovary(1)	1						TGGACCTGCAAGAGATCAACA	0.552													7	32					0	0	0	0	T	1675260	T	T	1675260	3	4	243	1	0	0	0	0	1	0	0	0	14179	69	3	5	548	5	SERPINF1	17	1675260	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08		1675260	79519950	94	44762											
TP53	7157	broad.mit.edu	37	chr17	7577022	7577022	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtcctgcttgcttacctcGcttagtgctccctgggggca	3	14	11	13	1	0	0	0	0	0	0	3	0	2	0	3	2	4	5	3	2	2	4	rs121913344		TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr17:7577022G>A	uc002gim.2	-	8	1110	c.916C>T	c.(916-918)CGA>TGA	p.R306*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.R306*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R174*|TP53_uc010cng.1_Nonsense_Mutation_p.R174*|TP53_uc002gii.1_Nonsense_Mutation_p.R174*|TP53_uc010cnh.1_Nonsense_Mutation_p.R306*|TP53_uc010cni.1_Nonsense_Mutation_p.R306*|TP53_uc002gij.2_Nonsense_Mutation_p.R306*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	306	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		R -> Q (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(99)|p.0?(7)|p.?(3)|p.R306R(2)|p.R306fs*39(2)|p.K305fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTACCTCGCTTAGTGCTC	0.562	R306*(MFE296_ENDOMETRIUM)|R306*(HCC1937_BREAST)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			83	19					0	0	0	0	A	7577022	A	A	7577022	4	1	243	1	0	0	0	0	0	1	0	0	16448	1095	38	1	370	1	TP53	17	7577022	Nonsense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	5901762	7577022	73618188	95	44763											
PFAS	5198	broad.mit.edu	37	chr17	8167249	8167249	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcaccatcactggagacCggagagtgagttggcccagg	9	6	16	10	1	1	3	1	1	0	2	1	5	1	3	3	5	0	2	3	5	0	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr17:8167249C>T	uc002gkr.2	+	15	1927	c.1786C>T	c.(1786-1788)CGG>TGG	p.R596W	PFAS_uc010vuv.1_Missense_Mutation_p.R172W|PFAS_uc010cnw.1_Intron|PFAS_uc002gks.2_5'Flank	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	596					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CACTGGAGACCGGAGAGTGAG	0.597													8	78					0	0	0	0	T	8167249	T	T	8167249	3	4	243	1	0	0	0	0	1	0	0	0	11809	643	23	1	1840	1	PFAS	17	8167249	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	590227	8167249	73027961	96	44764											
AKAP10	11216	broad.mit.edu	37	chr17	19835125	19835125	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatcagtcaatacctgagacGcagagctgtcagaactccct	13	8	8	12	1	3	3	3	1	0	3	4	4	4	3	2	0	3	2	2	0	4	1	rs139003893		TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr17:19835125G>A	uc002gwo.2	-	10	1771	c.1634C>T	c.(1633-1635)GCG>GTG	p.A545V	AKAP10_uc002gwp.1_Missense_Mutation_p.A545V|AKAP10_uc010cqw.1_Intron	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	545					blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					TACCTGAGACGCAGAGCTGTC	0.483													10	48					0	0	0	0	A	19835125	A	A	19835125	3	1	243	1	0	0	0	0	1	0	0	0	446	1087	38	1	378	1	AKAP10	17	19835125	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	11667876	19835125	61360085	97	44765											
VTN	7448	broad.mit.edu	37	chr17	26694894	26694894	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccggcgggagttctggttgCggccacggctgtggcctcgt	2	9	18	12	5	1	0	0	0	1	0	2	1	1	1	3	6	1	3	3	6	0	2	rs150566083		TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr17:26694894C>T	uc002hbc.2	-	7	1315	c.1166G>A	c.(1165-1167)CGC>CAC	p.R389H	SARM1_uc010wah.1_Intron|SEBOX_uc010wai.1_5'Flank|SEBOX_uc010crk.1_5'UTR|SARM1_uc010waj.1_Intron	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor	389	Heparin-binding.				cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	GTTCTGGTTGCGGCCACGGCT	0.592													12	30					0	0	0	0	T	26694894	T	T	26694894	3	4	243	1	0	0	0	0	1	0	0	0	17305	768	27	1	278	1	VTN	17	26694894	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	6859769	26694894	54500316	98	44766											
PIP4K2B	8396	broad.mit.edu	37	chr17	36927448	36927450	+	In_Frame_Del	DEL	CTC	-	-																															gcccgctcctccacctccatCtcctcctgctctgcccggtc																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr17:36927448_36927450delCTC	uc002hqs.2	-	8	1364_1366	c.883_885delGAG	c.(883-885)GAGdel	p.E295del	PIP4K2B_uc010cvp.2_5'Flank	NM_003559	NP_003550	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	295	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			ovary(1)	1						ccacctccatctcctcctgctcT	0.448													---	---	---								-	36927450	-	-	36927448	7	5	243	1	0	1	0	1	0	0	0	0	11992	912	32	0	377	0	PIP4K2B	17	36927448	In_Frame_Del	DEL	CTC	TCGA-CV-7255-01A-11D-2012-08	10232554	36927448	44267762	99	44767											
PLXDC1	57125	broad.mit.edu	37	chr17	37265528	37265528	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgccggtgggtgttggagagTattgtgtggatcttcacttg	5	15	16	5	1	2	1	1	0	1	1	2	3	2	2	1	4	1	2	1	4	1	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr17:37265528T>C	uc002hrg.2	-	3	584	c.372A>G	c.(370-372)ATA>ATG	p.I124M	PLXDC1_uc002hrh.2_RNA|PLXDC1_uc002hri.2_RNA|PLXDC1_uc002hrj.1_RNA|PLXDC1_uc002hrk.1_RNA	NM_020405	NP_065138	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1 precursor	124	Extracellular (Potential).				angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				ovary(1)|kidney(1)|skin(1)	3						TGTTGGAGAGTATTGTGTGGA	0.632													14	33					0	0	0	0	C	37265528	C	C	37265528	3	2	243	1	0	0	0	0	1	0	0	0	12172	1628	57	5	1178	5	PLXDC1	17	37265528	Missense_Mutation	SNP	T	TCGA-CV-7255-01A-11D-2012-08	338080	37265528	43929682	100	44768											
RAMP2	10266	broad.mit.edu	37	chr17	40914816	40914816	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccccatctgcctcatcccCttcctcatcactcttgtagt	5	13	4	19	0	5	0	3	0	2	0	7	0	7	0	6	0	1	1	6	0	1	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr17:40914816C>T	uc002ibg.2	+	4	542	c.474C>T	c.(472-474)CCC>CCT	p.P158P	LOC100190938_uc002ibd.1_5'Flank|LOC100190938_uc002ibe.3_5'Flank|LOC100190938_uc002ibf.3_5'Flank|RAMP2_uc010cyt.2_Silent_p.P163P|RAMP2_uc002ibh.2_3'UTR	NM_005854	NP_005845	O60895	RAMP2_HUMAN	receptor activity modifying protein 2 precursor	158	Helical; (Potential).				intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	coated pit|integral to plasma membrane|lysosome	protein transporter activity				0		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0741)	Pramlintide(DB01278)	GCCTCATCCCCTTCCTCATCA	0.567													17	49					0	0	0	0	T	40914816	T	T	40914816	2	4	243	1	0	0	0	0	0	0	0	1	13087	668	24	4		4	RAMP2	17	40914816	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	3649288	40914816	40280394	101	44769											
SOX9	6662	broad.mit.edu	37	chr17	70119789	70119789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccttgccagaggggggcaGacagccccctatcgacttcc	7	6	11	17	1	0	2	0	0	0	2	2	3	1	2	6	3	2	1	6	3	1	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr17:70119789G>A	uc002jiw.2	+	3	1163	c.791G>A	c.(790-792)AGA>AAA	p.R264K	uc002jiv.2_5'Flank	NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	264					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			GAGGGGGGCAGACAGCCCCCT	0.647													25	99					0	0	0	0	A	70119789	A	A	70119789	3	1	243	1	0	0	0	0	1	0	0	0	15022	942	33	2	801	2	SOX9	17	70119789	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	29204973	70119789	11075421	102	44770											
TXNDC2	84203	broad.mit.edu	37	chr18	9886722	9886722	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcacagaggagtctgatgcCtcacaggagggcgatgacct	10	6	14	11	2	2	3	1	2	1	1	2	6	2	5	2	3	1	1	2	3	0	0			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr18:9886722C>T	uc002koi.3	+	2	695	c.246C>T	c.(244-246)GCC>GCT	p.A82A	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Silent_p.A15A	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	82					cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						AGTCTGATGCCTCACAGGAGG	0.567													23	81					0	0	0	0	T	9886722	T	T	9886722	2	4	243	1	0	0	0	0	0	0	0	1	16865	668	24	4		4	TXNDC2	18	9886722	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08		9886722	68190526	103	44771											
MC2R	4158	broad.mit.edu	37	chr18	13885467	13885467	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acacgaggacagtcggaattAtttcttgctgtgttgttgat	9	15	11	6	2	1	1	0	1	1	0	2	4	1	3	0	2	1	3	0	2	2	5			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr18:13885467A>G	uc002ksp.1	-	2	228	c.51T>C	c.(49-51)AAT>AAC	p.N17N		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	17	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	AGTCGGAATTATTTCTTGCTG	0.433													9	39					0	0	0	0	G	13885467	G	G	13885467	2	3	243	1	0	0	0	0	0	0	0	1	9417	446	16	5		5	MC2R	18	13885467	Silent	SNP	A	TCGA-CV-7255-01A-11D-2012-08	3998745	13885467	64191781	104	44772											
SERPINB10	5273	broad.mit.edu	37	chr18	61602211	61602211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtcaaccctgagcagtatggGgatgagtgatgccttcagcc	9	9	13	10	0	2	3	2	3	0	0	2	4	2	4	3	2	4	2	3	2	2	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr18:61602211G>A	uc010xev.1	+	8	1019	c.929G>A	c.(928-930)GGG>GAG	p.G310E	SERPINB10_uc010xew.1_Missense_Mutation_p.G310E	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade	310						cytoplasm|nucleus	serine-type endopeptidase inhibitor activity			lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)				AGCAGTATGGGGATGAGTGAT	0.438													8	27					0	0	0	0	A	61602211	A	A	61602211	3	1	243	1	0	0	0	0	1	0	0	0	14162	1232	43	4	955	4	SERPINB10	18	61602211	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	47716744	61602211	16475037	105	44773											
CCL25	6370	broad.mit.edu	37	chr19	8122704	8122704	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaggccctcatgctgtaaaGaagttgagttctggaaactc	11	10	11	9	0	2	2	1	1	1	1	3	3	2	3	1	2	2	5	1	2	4	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr19:8122704G>C	uc002mjd.2	+	4	345	c.345G>C	c.(343-345)AAG>AAC	p.K115N	CCL25_uc002mjc.3_Missense_Mutation_p.K114N|CCL25_uc010dvy.1_Missense_Mutation_p.E71Q	NM_005624	NP_005615	O15444	CCL25_HUMAN	small inducible cytokine A25 precursor	115					chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|hormone activity				0						atgctgtaaagaagttgagtt	0													11	27					0	0	0	0	C	8122704	C	C	8122704	3	2	243	1	0	0	0	0	1	0	0	0	2910	933	33	2	359	2	CCL25	19	8122704	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08		8122704	51006279	106	44774											
KRI1	65095	broad.mit.edu	37	chr19	10675689	10675689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagcgttttgtaaaagtcccGctcctgctggggatcaaatt	9	12	11	9	2	1	0	1	0	0	0	3	2	3	1	2	2	2	4	2	2	3	4			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr19:10675689G>A	uc002moy.1	-	3	217	c.208C>T	c.(208-210)CGG>TGG	p.R70W	KRI1_uc002mox.1_Missense_Mutation_p.R66W	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	70										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			TAAAAGTCCCGCTCCTGCTGG	0.517											OREG0025239	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	52	39					0	0	0	0	A	10675689	A	A	10675689	3	1	243	1	0	0	0	0	1	0	0	0	8483	1086	38	1	1989	1	KRI1	19	10675689	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	2552985	10675689	48453294	107	44775											
FCHO1	23149	broad.mit.edu	37	chr19	17892312	17892312	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttcagccgccagcactgccTtggaacggcccagcttctta	7	9	9	16	2	2	0	1	0	1	0	2	1	2	1	4	2	5	2	4	2	2	4			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr19:17892312T>A	uc010ebb.2	+	21	1981	c.1792T>A	c.(1792-1794)TTG>ATG	p.L598M	FCHO1_uc002nhg.3_Missense_Mutation_p.L598M|FCHO1_uc002nhh.2_Missense_Mutation_p.L598M|FCHO1_uc010xpw.1_Missense_Mutation_p.L548M|FCHO1_uc002nhi.2_Missense_Mutation_p.L54M|FCHO1_uc002nhj.2_Translation_Start_Site	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	598										breast(1)	1						CAGCACTGCCTTGGAACGGCC	0.622													18	61					0	0	0	0	A	17892312	A	A	17892312	3	1	243	1	0	0	0	0	1	0	0	0	5819	1606	56	5	1866	5	FCHO1	19	17892312	Missense_Mutation	SNP	T	TCGA-CV-7255-01A-11D-2012-08	7216623	17892312	41236671	108	44776											
FCGBP	8857	broad.mit.edu	37	chr19	40392569	40392569	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agctcgggaggacactcctcGctggggatacagccctcgct	7	7	13	14	3	0	0	0	0	0	0	4	3	1	3	2	4	3	3	2	4	1	1	rs142183229	byFrequency	TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr19:40392569G>A	uc002omp.3	-	16	7943	c.7935C>T	c.(7933-7935)AGC>AGT	p.S2645S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	2645	VWFD 6.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GACACTCCTCGCTGGGGATAC	0.657													16	50					0	0	0	0	A	40392569	A	A	40392569	2	1	243	1	0	0	0	0	0	0	0	1	5810	1078	38	1		1	FCGBP	19	40392569	Silent	SNP	G	TCGA-CV-7255-01A-11D-2012-08	22500257	40392569	18736414	109	44777											
VN1R1	57191	broad.mit.edu	37	chr19	57967606	57967606	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agttggctgagaatcaagtcCgtgggtctcagcttgtgtcc	7	12	13	9	1	2	1	2	1	1	1	5	2	4	1	2	2	1	3	2	2	2	2	rs143275734		TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr19:57967606C>T	uc002qos.1	-	1	249	c.249G>A	c.(247-249)ACG>ACA	p.T83T	ZNF547_uc002qpm.3_Intron	NM_020633	NP_065684	Q9GZP7	VN1R1_HUMAN	vomeronasal 1 receptor 1	83	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity	p.T83R(1)		ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)|Breast(46;0.222)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)|Lung(386;0.171)		GAATCAAGTCCGTGGGTCTCA	0.423													8	22					0	0	0	0	T	57967606	T	T	57967606	2	4	243	1	0	0	0	0	0	0	0	1	17246	639	23	1		1	VN1R1	19	57967606	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	17575037	57967606	1161377	110	44778											
PXMP4	11264	broad.mit.edu	37	chr20	32307907	32307911	+	Frame_Shift_Del	DEL	CCGTT	-	-																															acggccccactcacacagccCcgttccggaagcccttaagc																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr20:32307907_32307911delCCGTT	uc002wzv.2	-	1	226_230	c.103_107delAACGG	c.(103-108)AACGGGfs	p.N35fs	PXMP4_uc002wzw.2_Frame_Shift_Del_p.N35fs|PXMP4_uc010zuh.1_Frame_Shift_Del_p.N35fs	NM_007238	NP_009169	Q9Y6I8	PXMP4_HUMAN	peroxisomal membrane protein 4 isoform a	35_36						integral to membrane|membrane fraction|mitochondrial inner membrane|peroxisomal membrane	protein transporter activity				0						TCACACAGCCCCGTTCCGGAAGCCC	0.688													---	---	---								-	32307911	-	-	32307907	7	5	243	1	0	1	0	1	0	0	0	0	12916	623	22	0	547	0	PXMP4	20	32307907	Frame_Shift_Del	DEL	CCGTT	TCGA-CV-7255-01A-11D-2012-08		32307907	30717613	111	44779											
ITCH	83737	broad.mit.edu	37	chr20	33033215	33033215	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaacaatggcagctacagcgTagtcagcttcaaggagcaat	14	7	11	9	1	2	0	2	0	0	0	2	2	2	1	0	2	6	5	0	2	6	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr20:33033215T>C	uc010geu.1	+	12	1404	c.1212T>C	c.(1210-1212)CGT>CGC	p.R404R	ITCH_uc002xak.2_Silent_p.R363R|ITCH_uc010zuj.1_Silent_p.R253R	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	404	Required for interaction with FYN.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						AGCTACAGCGTAGTCAGCTTC	0.423													27	55					0	0	0	0	C	33033215	C	C	33033215	2	2	243	1	0	0	0	0	0	0	0	1	7907	1625	57	5		5	ITCH	20	33033215	Silent	SNP	T	TCGA-CV-7255-01A-11D-2012-08	725308	33033215	29992305	112	44780											
PTPRT	11122	broad.mit.edu	37	chr20	40790072	40790072	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtcagccacccggatggCgggttggaactggtcccggg	7	6	16	12	3	1	0	1	0	0	0	2	2	2	2	3	6	2	1	3	6	2	1	rs61753667		TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr20:40790072C>T	uc002xkg.2	-	17	2786	c.2602G>A	c.(2602-2604)GCC>ACC	p.A868T	PTPRT_uc010ggj.2_Missense_Mutation_p.A887T|PTPRT_uc010ggi.2_Missense_Mutation_p.A71T	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	868	Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ACCCGGATGGCGGGTTGGAAC	0.622													24	98					0	0	0	0	T	40790072	T	T	40790072	3	4	243	1	0	0	0	0	1	0	0	0	12877	768	27	1	1783	1	PTPRT	20	40790072	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	7756857	40790072	22235448	113	44781											
SLC12A5	57468	broad.mit.edu	37	chr20	44676660	44676660	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgggatacgaggtctgtctCtcagtgcggctcgctatgcc	6	11	13	11	3	3	0	1	0	2	0	5	2	3	1	1	3	3	2	1	3	2	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr20:44676660C>T	uc010zxl.1	+	16	2093	c.2017C>T	c.(2017-2019)CTC>TTC	p.L673F	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.L650F	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	673					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGGTCTGTCTCTCAGTGCGGC	0.607													5	35					0	0	0	0	T	44676660	T	T	44676660	3	4	243	1	0	0	0	0	1	0	0	0	14451	913	32	2	2135	2	SLC12A5	20	44676660	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	3886588	44676660	18348860	114	44782											
CTCFL	140690	broad.mit.edu	37	chr20	56098320	56098320	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaataactggttcttctcCtgctcttcctcgagctaata	8	14	6	13	1	3	0	0	0	3	0	6	1	4	0	3	1	3	3	3	1	4	6			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr20:56098320C>T	uc010gix.1	-	2	1220	c.558G>A	c.(556-558)CAG>CAA	p.Q186Q	CTCFL_uc010giw.1_Silent_p.Q186Q|CTCFL_uc002xym.2_Silent_p.Q186Q|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Silent_p.Q186Q|CTCFL_uc010gjb.1_Silent_p.Q186Q|CTCFL_uc010gjc.1_Silent_p.Q186Q|CTCFL_uc010gjd.1_Silent_p.Q186Q|CTCFL_uc010gje.2_Silent_p.Q186Q|CTCFL_uc010gjf.2_5'UTR|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Silent_p.Q186Q|CTCFL_uc010gji.1_5'UTR|CTCFL_uc010gjj.1_Silent_p.Q186Q|CTCFL_uc010gjk.1_Silent_p.Q186Q|CTCFL_uc010gjl.1_Silent_p.Q186Q	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	186					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GGTTCTTCTCCTGCTCTTCCT	0.353													13	101					0	0	0	0	T	56098320	T	T	56098320	2	4	243	1	0	0	0	0	0	0	0	1	4018	680	24	4		4	CTCFL	20	56098320	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	11421660	56098320	6927200	115	44783											
NRIP1	8204	broad.mit.edu	37	chr21	16337046	16337049	+	Frame_Shift_Del	DEL	TTCT	-	-																															gcaggtacattttattctgaTtctttctttatcgttagcac																										TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr21:16337046_16337049delTTCT	uc002yjx.2	-	4	4063_4066	c.3465_3468delAGAA	c.(3463-3468)AAAGAAfs	p.K1155fs		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	1155_1156	Repression domain 4.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TTTATTCTGATTCTTTCTTTATCG	0.373													---	---	---								-	16337049	-	-	16337046	7	5	243	1	0	1	0	1	0	0	0	0	10706	1490	52	0	12	0	NRIP1	21	16337046	Frame_Shift_Del	DEL	TTCT	TCGA-CV-7255-01A-11D-2012-08		16337046	31792849	116	44784											
SLC16A8	23539	broad.mit.edu	37	chr22	38477107	38477107	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacgtgcggccgcagacgcGccaggcccgccagggcgccg	5	1	18	17	8	0	1	0	0	0	1	0	2	0	2	5	4	1	1	5	4	0	0			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr22:38477107G>T	uc003auu.2	-	4	1068	c.938C>A	c.(937-939)GCG>GAG	p.A313E		NM_013356	NP_037488	O95907	MOT3_HUMAN	solute carrier family 16, member 8	313	Cytoplasmic (Potential).				blood coagulation|leukocyte migration|pyruvate metabolic process	integral to plasma membrane|membrane fraction	lactate transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity				0	Melanoma(58;0.045)				Pyruvic acid(DB00119)	CCGCAGACGCGCCAGGCCCGC	0.741													4	8					2.56e-06	3.17134e-06	1	0	T	38477107	T	T	38477107	3	4	243	1	0	0	0	0	1	0	0	0	14479	1087	38	3	584	3	SLC16A8	22	38477107	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08		38477107	12827459	117	44785											
PHF21B	112885	broad.mit.edu	37	chr22	45289390	45289390	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctgtgcttcttctcttccGctcctgtcgcttgctctgga	1	16	10	14	2	3	0	0	0	3	0	7	1	5	1	2	2	2	5	2	2	0	4			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chr22:45289390G>A	uc003bfn.2	-	7	1058	c.907C>T	c.(907-909)CGG>TGG	p.R303W	PHF21B_uc003bfm.2_Missense_Mutation_p.R99W|PHF21B_uc011aqk.1_Missense_Mutation_p.R249W|PHF21B_uc011aql.1_Missense_Mutation_p.R261W|PHF21B_uc011aqm.1_Missense_Mutation_p.R249W	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	303							zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		CTTCTCTTCCGCTCCTGTCGC	0.632													4	8					0	0	0	0	A	45289390	A	A	45289390	3	1	243	1	0	0	0	0	1	0	0	0	11889	1086	38	1	716	1	PHF21B	22	45289390	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	6812283	45289390	6015176	118	44786											
PHKA2	5256	broad.mit.edu	37	chrX	18949759	18949759	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggccactaagcccctacCtctgccaacagcgagctgag	10	6	10	15	1	1	2	0	2	1	0	1	3	1	2	5	1	6	1	5	1	3	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chrX:18949759C>A	uc004cyv.3	-	12	1675	c.1245G>T	c.(1243-1245)GAG>GAT	p.E415D		NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	415					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					AAGCCCCTACCTCTGCCAACA	0.552											OREG0019698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	130					2.70662e-09	3.53779e-09	1	0	A	18949759	A	A	18949759	3	1	243	1	0	0	0	0	1	0	0	0	11899	695	24	4	2550	4	PHKA2	23	18949759	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08		18949759	136320801	119	44787											
SYTL5	94122	broad.mit.edu	37	chrX	37984588	37984588	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagcaaagccaccaagcacAaaactctggtaataaaaaag	21	5	6	9	0	1	0	0	0	1	0	1	0	1	0	2	1	4	3	2	1	9	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chrX:37984588A>G	uc004ddu.2	+	17	2413	c.1879A>G	c.(1879-1881)AAA>GAA	p.K627E	SYTL5_uc004ddv.2_Missense_Mutation_p.K627E|SYTL5_uc004ddx.2_Missense_Mutation_p.K649E	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	627	C2 2.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						CACCAAGCACAAAACTCTGGT	0.403													10	24					0	0	0	0	G	37984588	G	G	37984588	3	3	243	1	0	0	0	0	1	0	0	0	15552	131	5	5	2007	5	SYTL5	23	37984588	Missense_Mutation	SNP	A	TCGA-CV-7255-01A-11D-2012-08	19034829	37984588	117285972	120	44788											
AKAP4	8852	broad.mit.edu	37	chrX	49957377	49957377	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgttggacatggaagctgCtttgcttgccctgggctcag	5	13	13	10	0	2	0	1	0	1	0	2	2	2	2	1	3	4	5	1	3	1	3			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chrX:49957377C>A	uc004dow.1	-	5	2111	c.1987G>T	c.(1987-1989)GCA>TCA	p.A663S	AKAP4_uc004dov.1_Missense_Mutation_p.A280S|AKAP4_uc010njp.1_Missense_Mutation_p.A485S|AKAP4_uc004dou.1_Missense_Mutation_p.A654S	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	663					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					ATGGAAGCTGCTTTGCTTGCC	0.478													11	47					3.86212e-05	4.74898e-05	1	0	A	49957377	A	A	49957377	3	1	243	1	0	0	0	0	1	0	0	0	453	797	28	4	585	4	AKAP4	23	49957377	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	11972789	49957377	105313183	121	44789											
TRO	7216	broad.mit.edu	37	chrX	54955308	54955308	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccaagaaaatgcagatgcCagcaccaacgtcaacttcag	15	5	8	13	1	2	2	2	0	0	2	2	2	2	2	3	0	5	2	3	0	5	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chrX:54955308C>A	uc004dtq.2	+	12	2258	c.2151C>A	c.(2149-2151)GCC>GCA	p.A717A	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Silent_p.A248A|TRO_uc004dtw.2_Silent_p.A320A|TRO_uc004dtx.2_Silent_p.A100A	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	717					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						ATGCAGATGCCAGCACCAACG	0.512													21	33					1.01871e-10	1.36376e-10	1	0	A	54955308	A	A	54955308	2	1	243	1	0	0	0	0	0	0	0	1	16641	581	21	4		4	TRO	23	54955308	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	4997931	54955308	100315252	122	44790											
ZXDB	158586	broad.mit.edu	37	chrX	57619372	57619372	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacctgctgacgcacagcagCagccagggccagaggccctt	9	4	12	16	1	0	2	0	1	0	1	0	2	0	2	4	2	4	4	4	2	0	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chrX:57619372C>T	uc004dvd.2	+	1	1104	c.891C>T	c.(889-891)AGC>AGT	p.S297S		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	297	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						CGCACAGCAGCAGCCAGGGCC	0.642													4	12					0	0	0	0	T	57619372	T	T	57619372	2	4	243	1	0	0	0	0	0	0	0	1	18318	709	25	4		4	ZXDB	23	57619372	Silent	SNP	C	TCGA-CV-7255-01A-11D-2012-08	2664064	57619372	97651188	123	44791											
ZXDA	7789	broad.mit.edu	37	chrX	57936696	57936696	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcgccgccgcccgggcccGccatcttgggggccccgggg	1	4	17	19	7	1	0	0	0	1	0	2	0	1	0	7	5	0	0	7	5	0	1			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chrX:57936696G>A	uc004dve.2	-	1	372	c.159C>T	c.(157-159)GGC>GGT	p.G53G		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	53					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						gcccgggcccgccATCTTGGG	0.677													7	12					0	0	0	0	A	57936696	A	A	57936696	2	1	243	1	0	0	0	0	0	0	0	1	18317	1074	38	1		1	ZXDA	23	57936696	Silent	SNP	G	TCGA-CV-7255-01A-11D-2012-08	317324	57936696	97333864	124	44792											
MAGT1	84061	broad.mit.edu	37	chrX	77112872	77112872	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acattgacatcagttctgtcGgcgatccaccgggcaatctg	9	10	10	12	3	3	1	1	1	2	0	5	2	4	1	2	2	0	2	2	2	1	2			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chrX:77112872G>A	uc004fof.2	-	4	671	c.609C>T	c.(607-609)GCC>GCT	p.A203A	MAGT1_uc004fog.3_Intron	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	171					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						CAGTTCTGTCGGCGATCCACC	0.468													63	153					0	0	0	0	A	77112872	A	A	77112872	2	1	243	1	0	0	0	0	0	0	0	1	9249	1103	39	1		1	MAGT1	23	77112872	Silent	SNP	G	TCGA-CV-7255-01A-11D-2012-08	19176176	77112872	78157688	125	44793											
BRWD3	254065	broad.mit.edu	37	chrX	79978124	79978124	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acaattttcccgtcctggtaCcaaccgttggaattttgtgg	8	14	9	10	2	0	0	0	0	0	0	2	1	2	1	4	3	2	2	4	3	4	6			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chrX:79978124C>T	uc004edt.2	-	17	2076	c.1813G>A	c.(1813-1815)GTA>ATA	p.V605I	BRWD3_uc010nmi.1_5'Flank|BRWD3_uc004edo.2_Missense_Mutation_p.V201I|BRWD3_uc004edp.2_Missense_Mutation_p.V434I|BRWD3_uc004edq.2_Missense_Mutation_p.V201I|BRWD3_uc010nmj.1_Missense_Mutation_p.V201I|BRWD3_uc004edr.2_Missense_Mutation_p.V275I|BRWD3_uc004eds.2_Missense_Mutation_p.V201I|BRWD3_uc004edu.2_Missense_Mutation_p.V275I|BRWD3_uc004edv.2_Missense_Mutation_p.V201I|BRWD3_uc004edw.2_Missense_Mutation_p.V201I|BRWD3_uc004edx.2_Missense_Mutation_p.V201I|BRWD3_uc004edy.2_Missense_Mutation_p.V201I|BRWD3_uc004edz.2_Missense_Mutation_p.V275I|BRWD3_uc004eea.2_Missense_Mutation_p.V275I|BRWD3_uc004eeb.2_Missense_Mutation_p.V201I	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	605										ovary(4)	4						CGTCCTGGTACCAACCGTTGG	0.403													4	33					0	0	0	0	T	79978124	T	T	79978124	3	4	243	1	0	0	0	0	1	0	0	0	1531	507	18	4	3695	4	BRWD3	23	79978124	Missense_Mutation	SNP	C	TCGA-CV-7255-01A-11D-2012-08	2865252	79978124	75292436	126	44794											
MORF4L2	9643	broad.mit.edu	37	chrX	102931661	102931661	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcccgggcccttttcttccGagggggctgaggtgcttcgc	2	11	15	13	3	1	1	0	1	1	0	3	2	2	1	3	4	2	2	3	4	0	4			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chrX:102931661G>A	uc004ekw.2	-	4	1527	c.295C>T	c.(295-297)CGG>TGG	p.R99W	MORF4L2_uc004ela.2_Missense_Mutation_p.R99W|MORF4L2_uc004ekx.2_Missense_Mutation_p.R99W|MORF4L2_uc004elb.2_Missense_Mutation_p.R99W|MORF4L2_uc004eky.2_Missense_Mutation_p.R99W|MORF4L2_uc010nos.2_Missense_Mutation_p.R99W|MORF4L2_uc004ekz.2_Missense_Mutation_p.R99W|MORF4L2_uc011mry.1_Missense_Mutation_p.R99W|MORF4L2_uc011mrz.1_Missense_Mutation_p.R99W|MORF4L2_uc004elc.2_Missense_Mutation_p.R99W|MORF4L2_uc004elf.2_Missense_Mutation_p.R99W|MORF4L2_uc004ele.2_Missense_Mutation_p.R99W|MORF4L2_uc011msa.1_Missense_Mutation_p.R99W|MORF4L2_uc011msb.1_Missense_Mutation_p.R99W|MORF4L2_uc011msc.1_Missense_Mutation_p.R99W|MORF4L2_uc011msd.1_Missense_Mutation_p.R99W|MORF4L2_uc004eld.2_Missense_Mutation_p.R99W	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	99					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						CTTTTCTTCCGAGGGGGCTGA	0.512													34	134					0	0	0	0	A	102931661	A	A	102931661	3	1	243	1	0	0	0	0	1	0	0	0	9760	1057	37	1	575	1	MORF4L2	23	102931661	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	22953537	102931661	52338899	127	44795											
DCAF12L1	139170	broad.mit.edu	37	chrX	125686191	125686191	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctcactgtcccgcaagaggGgaatgcgcgcgatgtggcct	7	7	14	13	4	1	1	1	0	0	1	2	3	2	2	3	3	1	1	3	3	2	0			TCGA-CV-7255-01A-11D-2012-08	TCGA-CV-7255-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dedba61-e137-4ae4-8312-94231e3b1d16	90409946-46de-41a9-bb8a-b495ce346df2	g.chrX:125686191G>C	uc004eul.2	-	1	652	c.401C>G	c.(400-402)CCC>CGC	p.P134R		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	134										skin(3)|ovary(1)	4						CCGCAAGAGGGGAATGCGCGC	0.632													17	72					0	0	0	0	C	125686191	C	C	125686191	3	2	243	1	0	0	0	0	1	0	0	0	4281	1232	43	4	994	4	DCAF12L1	23	125686191	Missense_Mutation	SNP	G	TCGA-CV-7255-01A-11D-2012-08	22754530	125686191	29584369	128	44796											
CELA3B	23436	broad.mit.edu	37	chr1	22313089	22313089	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcaggtccatggcgtgacCagctttgtttctgcctttgg	4	14	13	10	1	1	1	0	1	1	0	2	1	2	1	3	4	2	3	3	4	0	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:22313089C>G	uc001bfk.2	+	7	823	c.708C>G	c.(706-708)ACC>ACG	p.T236T	CELA3B_uc009vqf.2_Intron	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	236	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						ATGGCGTGACCAGCTTTGTTT	0.607													11	30					0	0	0	0	G	22313089	G	G	22313089	2	3	244	1	0	0	0	0	0	0	0	1	3229	581	21	4		4	CELA3B	1	22313089	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08		22313089	226937532	1	44797											
IGSF3	3321	broad.mit.edu	37	chr1	117131576	117131576	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggtcttcaggataagcttgCcatcggcatccgagggcttg	7	11	13	10	2	2	0	1	0	1	0	4	2	3	1	2	4	2	3	2	4	1	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:117131576C>G	uc001egr.1	-	8	2885	c.2180G>C	c.(2179-2181)GGC>GCC	p.G727A	IGSF3_uc001egq.1_Missense_Mutation_p.G747A|IGSF3_uc001egs.1_Missense_Mutation_p.G400A	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	727	Ig-like C2-type 6.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GATAAGCTTGCCATCGGCATC	0.547													29	98					0	0	0	0	G	117131576	G	G	117131576	3	3	244	1	0	0	0	0	1	0	0	0	7640	739	26	4	1420	4	IGSF3	1	117131576	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	94818487	117131576	132119045	2	44798											
BCL9	607	broad.mit.edu	37	chr1	147092754	147092754	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacttcctgccccgtcaccTggatggacctcttctccaaa	7	11	6	17	1	4	0	2	0	2	0	6	2	5	2	6	2	1	0	6	2	1	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:147092754T>A	uc001epq.2	+	8	3533	c.2793T>A	c.(2791-2793)CCT>CCA	p.P931P	BCL9_uc010ozr.1_Silent_p.P857P	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	931	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CCCCGTCACCTGGATGGACCT	0.582			T	IGH@|IGL@	B-ALL								17	114					0	0	0	0	A	147092754	A	A	147092754	2	1	244	1	0	0	0	0	0	0	0	1	1383	1567	55	5		5	BCL9	1	147092754	Silent	SNP	T	TCGA-CV-7261-01A-11D-2012-08	29961178	147092754	102157867	3	44799											
NBPF15	284565	broad.mit.edu	37	chr1	148594624	148594624	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggtgttccagatgggagTcatattcccacaataagcag	11	10	10	10	0	1	1	1	0	0	1	3	2	3	2	3	2	1	2	3	2	3	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:148594624T>C	uc001esc.2	+	19	2486	c.1997T>C	c.(1996-1998)GTC>GCC	p.V666A		NM_173638	NP_775909	Q8N660	NBPFF_HUMAN	hypothetical protein LOC284565	666	NBPF 6.					cytoplasm					0	all_hematologic(923;0.032)					CAGATGGGAGTCATATTCCCA	0.448													3	132					0	0	0	0	C	148594624	C	C	148594624	3	2	244	1	0	0	0	0	1	0	0	0	10249	1667	58	5	2055	5	NBPF15	1	148594624	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08	1501870	148594624	100655997	4	44800											
BCAN	63827	broad.mit.edu	37	chr1	156616600	156616600	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccgttcacagaggaccgCgcttttcgcgtgcgcatcgc	6	8	11	16	7	1	1	1	0	0	1	3	2	1	2	2	1	1	3	2	1	0	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:156616600C>T	uc001fpp.2	+	3	435	c.99C>T	c.(97-99)CGC>CGT	p.R33R	BCAN_uc001fpo.2_Silent_p.R33R	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	33					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CAGAGGACCGCGCTTTTCGCG	0.697													5	20					0	0	0	0	T	156616600	T	T	156616600	2	4	244	1	0	0	0	0	0	0	0	1	1347	755	27	1		1	BCAN	1	156616600	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	8021976	156616600	92634021	5	44801											
NES	10763	broad.mit.edu	37	chr1	156640375	156640375	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctctgaccccagaggccaaGgtgaaggggcatcacttcca	10	6	11	14	0	2	3	1	2	1	1	3	3	3	3	5	4	0	1	5	4	2	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:156640375G>A	uc001fpq.2	-	4	3738	c.3605C>T	c.(3604-3606)CCT>CTT	p.P1202L		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1202	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CAGAGGCCAAGGTGAAGGGGC	0.647													5	104					0	0	0	0	A	156640375	A	A	156640375	3	1	244	1	0	0	0	0	1	0	0	0	10391	1000	35	4	1264	4	NES	1	156640375	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	23775	156640375	92610246	6	44802											
FCRL1	115350	broad.mit.edu	37	chr1	157776893	157776893	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaaggaagtgcaactcaccGgcaggttcacagagtggagc	14	5	13	9	1	2	1	2	0	0	1	2	3	2	3	1	4	3	3	1	4	4	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:157776893G>A	uc001frg.2	-	2	164	c.51C>T	c.(49-51)GCC>GCT	p.A17A	FCRL1_uc001frh.2_Silent_p.A17A|FCRL1_uc001fri.2_Silent_p.A17A|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	17	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GCAACTCACCGGCAGGTTCAC	0.483													15	73					0	0	0	0	A	157776893	A	A	157776893	2	1	244	1	0	0	0	0	0	0	0	1	5826	1130	39	1		1	FCRL1	1	157776893	Silent	SNP	G	TCGA-CV-7261-01A-11D-2012-08	1136518	157776893	91473728	7	44803											
CD1C	911	broad.mit.edu	37	chr1	158262428	158262428	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtcgccccagccttgggtCtggccagctgttgctggttt	3	12	13	13	1	1	0	0	0	1	0	2	0	1	0	4	3	3	4	4	3	0	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:158262428C>T	uc001fru.2	+	4	945	c.653C>T	c.(652-654)TCT>TTT	p.S218F	CD1C_uc001frv.2_Missense_Mutation_p.S21F	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	218	Extracellular (Potential).|Ig-like.				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					AGCCTTGGGTCTGGCCAGCTG	0.522													6	66					0	0	0	0	T	158262428	T	T	158262428	3	4	244	1	0	0	0	0	1	0	0	0	2991	913	32	2	667	2	CD1C	1	158262428	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	485535	158262428	90988193	8	44804											
OR10J1	26476	broad.mit.edu	37	chr1	159409809	159409809	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagactgtatatacattggtCattctcccaagaatgctctc	11	13	7	10	0	3	2	1	0	2	2	5	3	3	2	1	1	2	2	1	1	5	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:159409809C>T	uc010piv.1	+	1	261	c.261C>T	c.(259-261)GTC>GTT	p.V87V	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	87	Extracellular (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					ATACATTGGTCATTCTCCCAA	0.458													7	77					0	0	0	0	T	159409809	T	T	159409809	2	4	244	1	0	0	0	0	0	0	0	1	10964	813	29	2		2	OR10J1	1	159409809	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	1147381	159409809	89840812	9	44805											
TPR	7175	broad.mit.edu	37	chr1	186344683	186344683	+	5'Flank	DEL	G	-	-																															gccctccctgaagagctggtGaccttaccgtcaaagccccg																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:186344683delG	uc001grv.2	-						C1orf27_uc001grw.2_5'Flank|C1orf27_uc010poq.1_5'Flank|C1orf27_uc010por.1_5'Flank|TPR_uc010pop.1_Intron	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		AAGAGCTGGTGACCTTACCGT	0.662			T	NTRK1	papillary thyroid						OREG0014055	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	186344683	-	-	186344683	6	5	244	0	1	1	0	1	0	0	0	0	16483	1305	45	0		0	TPR	1	186344683	5'Flank	DEL	G	TCGA-CV-7261-01A-11D-2012-08	26934874	186344683	62905938	10	44806											
CRB1	23418	broad.mit.edu	37	chr1	197390386	197390386	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgtccatctggctacacCgggtccctgtgtgaaatcgc	7	11	10	13	2	1	1	0	1	1	0	4	1	3	1	3	2	1	1	3	2	3	2	rs62636282	byFrequency	TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:197390386C>T	uc001gtz.2	+	6	1563	c.1428C>T	c.(1426-1428)ACC>ACT	p.T476T	CRB1_uc010poz.1_Silent_p.T407T|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.T364T|CRB1_uc010ppb.1_Silent_p.T476T|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_Silent_p.T125T	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	476	Extracellular (Potential).|EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CTGGCTACACCGGGTCCCTGT	0.502													12	57					0	0	0	0	T	197390386	T	T	197390386	2	4	244	1	0	0	0	0	0	0	0	1	3863	639	23	1		1	CRB1	1	197390386	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	11045703	197390386	51860235	11	44807											
RPS6KC1	26750	broad.mit.edu	37	chr1	213436131	213436131	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaacatgccagaatgtgtctCtgaagaggctcgctcactca	11	9	10	11	1	3	3	2	1	1	2	5	4	3	3	1	1	2	2	1	1	3	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:213436131C>G	uc010ptr.1	+	14	3221	c.3062C>G	c.(3061-3063)TCT>TGT	p.S1021C	RPS6KC1_uc001hkd.2_Missense_Mutation_p.S1009C|RPS6KC1_uc010pts.1_Missense_Mutation_p.S809C|RPS6KC1_uc010ptt.1_Missense_Mutation_p.S809C|RPS6KC1_uc010ptu.1_Missense_Mutation_p.S840C|RPS6KC1_uc010ptv.1_Missense_Mutation_p.S556C|RPS6KC1_uc001hke.2_Missense_Mutation_p.S840C	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	1021	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		GAATGTGTCTCTGAAGAGGCT	0.428													22	42					0	0	0	0	G	213436131	G	G	213436131	3	3	244	1	0	0	0	0	1	0	0	0	13723	913	32	2	3116	2	RPS6KC1	1	213436131	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	16045745	213436131	35814490	12	44808											
TRIM58	25893	broad.mit.edu	37	chr1	248028119	248028119	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctggaggcggaggagcgagCgacgctgcagagactgcggg	8	3	21	9	5	0	1	0	0	0	1	0	7	0	4	0	5	4	3	0	5	0	0	rs138082117	byFrequency	TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr1:248028119C>A	uc001ido.2	+	3	677	c.629C>A	c.(628-630)GCG>GAG	p.A210E		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	210	Potential.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAGGAGCGAGCGACGCTGCAG	0.652													14	35					9.31168e-06	6.62301e-05	1	0	A	248028119	A	A	248028119	3	1	244	1	0	0	0	0	1	0	0	0	16598	768	27	3	639	3	TRIM58	1	248028119	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	34591988	248028119	1222502	13	44809											
NCOA1	8648	broad.mit.edu	37	chr2	24905921	24905921	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacaatcaggaggaattaatGaatacgagcgtctacagcat	16	9	9	7	2	2	1	1	1	1	0	2	4	2	3	0	2	5	1	0	2	7	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:24905921G>C	uc002rfk.2	+	6	714	c.456G>C	c.(454-456)ATG>ATC	p.M152I	NCOA1_uc010eye.2_Missense_Mutation_p.M152I|NCOA1_uc002rfi.2_Missense_Mutation_p.M1I|NCOA1_uc002rfj.2_Missense_Mutation_p.M152I|NCOA1_uc002rfl.2_Missense_Mutation_p.M152I	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	152	PAS.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAATTAATGAATACGAGCG	0.378			T	PAX3	alveolar rhadomyosarcoma								3	42					0	0	0	0	C	24905921	C	C	24905921	3	2	244	1	0	0	0	0	1	0	0	0	10282	1290	45	2	470	2	NCOA1	2	24905921	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08		24905921	218293452	14	44810											
PSME4	23198	broad.mit.edu	37	chr2	54133994	54133994	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtgctctgatatgttgtttTttcccatggagctggaaaac	9	15	10	7	0	1	1	0	1	1	0	2	3	2	3	1	2	3	4	1	2	3	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:54133994T>C	uc002rxp.2	-	25	2852	c.2796A>G	c.(2794-2796)AAA>AAG	p.K932K	PSME4_uc010yop.1_Silent_p.K818K|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Silent_p.K307K|PSME4_uc010fbv.1_Silent_p.K76K	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	932					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TATGTTGTTTTTTCCCATGGA	0.328													3	64					0	0	0	0	C	54133994	C	C	54133994	2	2	244	1	0	0	0	0	0	0	0	1	12771	1838	64	5		5	PSME4	2	54133994	Silent	SNP	T	TCGA-CV-7261-01A-11D-2012-08	29228073	54133994	189065379	15	44811											
TMSB10	9168	broad.mit.edu	37	chr2	85133166	85133166	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagacaaaccagacatggggGaaatcgccagcttcgataag	15	5	11	10	2	0	2	0	0	0	2	2	4	0	3	2	2	2	1	2	2	3	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:85133166G>A	uc002sow.1	+	2	120	c.25G>A	c.(25-27)GAA>AAA	p.E9K		NM_021103	NP_066926	P63313	TYB10_HUMAN	thymosin, beta 10	9					actin cytoskeleton organization|sequestering of actin monomers	cytoplasm|cytoskeleton	actin binding				0						AGACATGGGGGAAATCGCCAG	0.582													23	31					0	0	0	0	A	85133166	A	A	85133166	3	1	244	1	0	0	0	0	1	0	0	0	16320	1175	41	2	27	2	TMSB10	2	85133166	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	30999172	85133166	158066207	16	44812											
RGPD3	653489	broad.mit.edu	37	chr2	107040930	107040931	+	Frame_Shift_Ins	INS	-	A	A																															agaagccgctggcattcctcINSaaatttctgcttgaattctt																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:107040930_107040931insA	uc010ywi.1	-	20	3549_3550	c.3492_3493insT	c.(3490-3495)TTTGAGfs	p.F1164fs		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1164_1165	RanBD1 1.				intracellular transport		binding			ovary(1)	1						TGGCATTCCTCAAATTTCTGCT	0.436													---	---	---								A	107040931	A	A	107040930	7	5	244	1	0	1	1	0	0	0	0	0	13352	835	29	0	1799	0	RGPD3	2	107040930	Frame_Shift_Ins	INS	-	TCGA-CV-7261-01A-11D-2012-08	21907764	107040930	136158443	17	44813											
LRP1B	53353	broad.mit.edu	37	chr2	141093261	141093261	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtgcagttggggccattCagctgccctacgttgataga	7	11	13	10	1	1	2	1	1	0	1	1	2	1	2	2	3	4	4	2	3	2	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:141093261C>T	uc002tvj.1	-	78	13011	c.12039G>A	c.(12037-12039)CTG>CTA	p.L4013L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4013	Extracellular (Potential).|LDL-receptor class B 34.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGGGGCCATTCAGCTGCCCTA	0.433										TSP Lung(27;0.18)			7	156					0	0	0	0	T	141093261	T	T	141093261	2	4	244	1	0	0	0	0	0	0	0	1	9005	813	29	2		2	LRP1B	2	141093261	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	34052331	141093261	102106112	18	44814											
XIRP2	129446	broad.mit.edu	37	chr2	168101029	168101029	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaataattagaggaataTctgctcaagaaatacagact	18	11	6	6	0	3	3	2	0	1	3	3	4	3	4	0	1	2	1	0	1	8	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:168101029T>C	uc002udx.2	+	8	3145	c.3127T>C	c.(3127-3129)TCT>CCT	p.S1043P	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.S868P|XIRP2_uc010fpq.2_Missense_Mutation_p.S821P|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	868					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TAGAGGAATATCTGCTCAAGA	0.353													9	19					0	0	0	0	C	168101029	C	C	168101029	3	2	244	1	0	0	0	0	1	0	0	0	17498	1435	50	5	3157	5	XIRP2	2	168101029	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08	27007768	168101029	75098344	19	44815											
XIRP2	129446	broad.mit.edu	37	chr2	168102825	168102825	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgactaaaactcaattattAaacagatcaactgaatttca	18	13	3	7	0	3	3	3	2	0	1	3	3	3	3	0	0	3	0	0	0	8	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:168102825A>G	uc002udx.2	+	8	4941	c.4923A>G	c.(4921-4923)TTA>TTG	p.L1641L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.L1466L|XIRP2_uc010fpq.2_Silent_p.L1419L|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1466					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTCAATTATTAAACAGATCAA	0.328													8	30					0	0	0	0	G	168102825	G	G	168102825	2	3	244	1	0	0	0	0	0	0	0	1	17498	359	13	5		5	XIRP2	2	168102825	Silent	SNP	A	TCGA-CV-7261-01A-11D-2012-08	1796	168102825	75096548	20	44816											
LRP2	4036	broad.mit.edu	37	chr2	170062018	170062018	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacccagtagagaaggtcCtcttcatagtccagagtcag	11	9	9	12	0	3	2	2	0	1	2	6	3	6	2	4	1	0	1	4	1	3	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:170062018C>A	uc002ues.2	-	41	7899	c.7686G>T	c.(7684-7686)GAG>GAT	p.E2562D		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2562	LDL-receptor class B 27.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGAGAAGGTCCTCTTCATAGT	0.483													11	100					0.00136819	0.00912696	1	0	A	170062018	A	A	170062018	3	1	244	1	0	0	0	0	1	0	0	0	9006	680	24	4	6437	4	LRP2	2	170062018	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	1959193	170062018	73137355	21	44817											
TTN	7273	broad.mit.edu	37	chr2	179435389	179435389	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cggtgctctttatttctaatCgagctgtgtttgaaagctcc	7	16	9	9	2	2	1	0	1	2	0	4	2	3	1	1	1	3	4	1	1	3	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:179435389C>G	uc010zfg.1	-	275	67990	c.67766G>C	c.(67765-67767)CGA>CCA	p.R22589P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16284P|TTN_uc010zfi.1_Missense_Mutation_p.R16217P|TTN_uc010zfj.1_Missense_Mutation_p.R16092P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23516							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTTCTAATCGAGCTGTGTT	0.413													10	99					0	0	0	0	G	179435389	G	G	179435389	3	3	244	1	0	0	0	0	1	0	0	0	16803	884	31	3	32657	3	TTN	2	179435389	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	9373371	179435389	63763984	22	44818											
TTN	7273	broad.mit.edu	37	chr2	179640223	179640223	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggccagtaccagtagatcCggtcagaccgttcaattttg	9	10	11	11	3	2	2	2	0	0	2	3	2	3	2	4	2	1	3	4	2	3	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:179640223C>T	uc010zfg.1	-	28	6592	c.6368G>A	c.(6367-6369)CGG>CAG	p.R2123Q	TTN_uc010zfh.1_Missense_Mutation_p.R2077Q|TTN_uc010zfi.1_Missense_Mutation_p.R2077Q|TTN_uc010zfj.1_Missense_Mutation_p.R2077Q|TTN_uc002unb.2_Missense_Mutation_p.R2123Q|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2123							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAGTAGATCCGGTCAGACCG	0.483													16	38					0	0	0	0	T	179640223	T	T	179640223	3	4	244	1	0	0	0	0	1	0	0	0	16803	652	23	1	104960	1	TTN	2	179640223	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	204834	179640223	63559150	23	44819											
TTLL4	9654	broad.mit.edu	37	chr2	219603790	219603790	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaaactcttggcatagccaAcgtggccacccgcctctctt	8	10	7	16	2	3	0	1	0	2	0	4	0	3	0	4	2	3	1	4	2	3	3	rs148659460	byFrequency	TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:219603790A>G	uc002viy.2	+	3	1761	c.1391A>G	c.(1390-1392)AAC>AGC	p.N464S	TTLL4_uc010zkl.1_Missense_Mutation_p.N299S|TTLL4_uc010fvx.2_Missense_Mutation_p.N464S	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	464					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		GGCATAGCCAACGTGGCCACC	0.532													12	12					0	0	0	0	G	219603790	G	G	219603790	3	3	244	1	0	0	0	0	1	0	0	0	16797	43	2	5	1393	5	TTLL4	2	219603790	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08	39963567	219603790	23595583	24	44820											
CCDC108	255101	broad.mit.edu	37	chr2	219888039	219888039	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcagacgcgaggggttgcGgaaggtgaaggggctggtgg	7	5	24	5	3	0	2	0	1	0	1	0	4	0	3	0	9	1	3	0	9	2	1	rs138095762		TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:219888039G>A	uc002vjl.1	-	16	2794	c.2710C>T	c.(2710-2712)CGC>TGC	p.R904C		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	904	MSP.					integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAGGGGTTGCGGAAGGTGAAG	0.637													9	23					0	0	0	0	A	219888039	A	A	219888039	3	1	244	1	0	0	0	0	1	0	0	0	2755	1116	39	1	3147	1	CCDC108	2	219888039	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	284249	219888039	23311334	25	44821											
UGT1A8	54576	broad.mit.edu	37	chr2	234526223	234526224	+	5'Flank	INS	-	T	T																															atcattggcagtgagtgtgaINSttttttttttttttatgaca																								rs34872923		TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr2:234526223_234526224insT	uc002vup.2	+						UGT1A8_uc010zmv.1_5'Flank	NM_019076	NP_061949	Q9HAW9	UD18_HUMAN	UDP glycosyltransferase 1 family, polypeptide A8						drug metabolic process|fatty acid metabolic process|flavone metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme inhibitor activity|fatty acid binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|steroid binding			ovary(2)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGTGAGTGTGATTTTTTTTTTT	0.361											OREG0003838	type=REGULATORY REGION|Gene=UGT1A8|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---								T	234526224	T	T	234526223	6	5	244	0	1	1	1	0	0	0	0	0	17019	348	12	0		0	UGT1A8	2	234526223	5'Flank	INS	-	TCGA-CV-7261-01A-11D-2012-08	14638184	234526223	8673150	26	44822											
CNTN6	27255	broad.mit.edu	37	chr3	1415634	1415634	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaattctcaatggtaagacaTacaatgcaacagtggttggt	15	11	9	6	0	1	1	1	0	1	1	2	1	1	1	0	3	3	3	0	3	6	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:1415634T>C	uc003boz.2	+	16	2239	c.1972T>C	c.(1972-1974)TAC>CAC	p.Y658H	CNTN6_uc011asj.1_Missense_Mutation_p.Y586H|CNTN6_uc003bpa.2_Missense_Mutation_p.Y658H	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	658	Fibronectin type-III 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TGGTAAGACATACAATGCAAC	0.383													3	26					0	0	0	0	C	1415634	C	C	1415634	3	2	244	1	0	0	0	0	1	0	0	0	3660	1406	49	5	2030	5	CNTN6	3	1415634	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08		1415634	196606796	27	44823											
CCRL2	9034	broad.mit.edu	37	chr3	46449784	46449784	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatataaaggactcaaacgcGtggaaaatatctatcttcta	17	11	6	7	2	4	0	1	0	3	0	4	2	4	2	0	2	1	0	0	2	10	6			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:46449784G>A	uc003cpp.3	+	2	499	c.214G>A	c.(214-216)GTG>ATG	p.V72M	CCRL2_uc010hjg.2_Missense_Mutation_p.V84M|CCRL2_uc010hjf.2_Missense_Mutation_p.V72M	NM_003965	NP_003956	O00421	CCRL2_HUMAN	chemokine (C-C motif) receptor-like 2 isoform 1	72	Cytoplasmic (Potential).				chemotaxis|inflammatory response	integral to plasma membrane	CCR chemokine receptor binding|chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)		ACTCAAACGCGTGGAAAATAT	0.468													23	31					0	0	0	0	A	46449784	A	A	46449784	3	1	244	1	0	0	0	0	1	0	0	0	2965	1145	40	1	256	1	CCRL2	3	46449784	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	45034150	46449784	151572646	28	44824											
RBM6	10180	broad.mit.edu	37	chr3	50103889	50103889	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgcagaaggcagtttcccaAtaaagaagttctgatcaaac	15	10	8	8	0	2	3	1	1	1	2	3	3	3	3	1	1	2	4	1	1	6	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:50103889A>T	uc003cyc.2	+	17	3030	c.2897A>T	c.(2896-2898)AAT>ATT	p.N966I	RBM6_uc010hlc.1_3'UTR|RBM6_uc003cyd.2_Missense_Mutation_p.N444I|RBM6_uc003cye.2_Missense_Mutation_p.N444I|RBM6_uc011bdi.1_Missense_Mutation_p.N308I|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	966					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		CAGTTTCCCAATAAAGAAGTT	0.438													50	65					0	0	0	0	T	50103889	T	T	50103889	3	4	244	1	0	0	0	0	1	0	0	0	13209	101	4	5	2959	5	RBM6	3	50103889	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08	3654105	50103889	147918541	29	44825											
PARP14	54625	broad.mit.edu	37	chr3	122418794	122418794	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaaaattaaaagggaagagCaaagtttgaaggaaaaaatg	24	6	10	1	0	0	2	0	1	0	1	0	4	0	4	0	2	1	2	0	2	11	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:122418794C>A	uc003efq.3	+	6	1452	c.1393C>A	c.(1393-1395)CAA>AAA	p.Q465K	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.Q182K|PARP14_uc003efs.1_Missense_Mutation_p.Q182K	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		AAGGGAAGAGCAAAGTTTGAA	0.403													30	27					2.12542e-12	1.58521e-11	1	0	A	122418794	A	A	122418794	3	1	244	1	0	0	0	0	1	0	0	0	11512	711	25	4	1415	4	PARP14	3	122418794	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	72314905	122418794	75603636	30	44826											
KALRN	8997	broad.mit.edu	37	chr3	124431825	124431825	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgcattcacaaagctaccCgcaaagatgtggctgtgaaa	15	8	9	9	1	1	2	1	1	0	1	1	2	1	2	1	1	3	4	1	1	5	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:124431825C>A	uc003ehg.2	+	58	8246	c.8119C>A	c.(8119-8121)CGC>AGC	p.R2707S	KALRN_uc003ehk.2_Missense_Mutation_p.R1010S	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2706	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CAAAGCTACCCGCAAAGATGT	0.413													17	55					2.23348e-06	1.60991e-05	1	0	A	124431825	A	A	124431825	3	1	244	1	0	0	0	0	1	0	0	0	8014	652	23	3	8505	3	KALRN	3	124431825	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	2013031	124431825	73590605	31	44827											
PLXNA1	5361	broad.mit.edu	37	chr3	126747877	126747877	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgcatcatcctgcaggacGaggacgtcaccaccaagatt	11	6	10	14	4	2	1	2	0	0	1	3	4	3	3	3	2	1	2	3	2	1	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:126747877G>T	uc003ejg.2	+	25	4646	c.4642G>T	c.(4642-4644)GAG>TAG	p.E1548*	PLXNA1_uc003ejh.2_Nonsense_Mutation_p.E216*	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1571	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CCTGCAGGACGAGGACGTCAC	0.657													16	40					3.57192e-18	2.74018e-17	1	0	T	126747877	T	T	126747877	4	4	244	1	0	0	0	0	0	1	0	0	12174	1059	37	3	4809	3	PLXNA1	3	126747877	Nonsense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	2316052	126747877	71274553	32	44828											
IFT122	55764	broad.mit.edu	37	chr3	129182445	129182445	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctgtctccaaacacaaatCaagcagcaagatcatctgct	14	9	6	12	0	5	1	2	0	3	1	6	1	5	1	1	0	4	3	1	0	4	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:129182445C>G	uc003emm.2	+	6	598	c.392C>G	c.(391-393)TCA>TGA	p.S131*	IFT122_uc003eml.2_Nonsense_Mutation_p.S182*|IFT122_uc003emn.2_Nonsense_Mutation_p.S131*|IFT122_uc003emo.2_Nonsense_Mutation_p.S79*|IFT122_uc003emp.2_Translation_Start_Site|IFT122_uc010htc.2_Nonsense_Mutation_p.S182*|IFT122_uc011bky.1_Translation_Start_Site|IFT122_uc003emq.2_Nonsense_Mutation_p.S79*|IFT122_uc003emr.2_Translation_Start_Site|IFT122_uc011bla.1_Translation_Start_Site|IFT122_uc011bkx.1_Nonsense_Mutation_p.S79*|IFT122_uc011bkz.1_RNA	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	131	WD 4.				camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						AAACACAAATCAAGCAGCAAG	0.358													4	61					0	0	0	0	G	129182445	G	G	129182445	4	3	244	1	0	0	0	0	0	1	0	0	7594	838	29	2	571	2	IFT122	3	129182445	Nonsense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	2434568	129182445	68839985	33	44829											
SLC9A9	285195	broad.mit.edu	37	chr3	142987754	142987754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtaagcagcctggaaatcGgaccacaccattcaggtaat	13	8	10	10	1	1	0	1	0	0	0	2	2	1	2	3	4	2	3	3	4	3	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:142987754G>A	uc003evn.2	-	15	1855	c.1673C>T	c.(1672-1674)CCG>CTG	p.P558L		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	558					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						CCTGGAAATCGGACCACACCA	0.478													7	171					0	0	0	0	A	142987754	A	A	142987754	3	1	244	1	0	0	0	0	1	0	0	0	14785	1116	39	1	272	1	SLC9A9	3	142987754	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	13805309	142987754	55034676	34	44830											
SI	6476	broad.mit.edu	37	chr3	164727148	164727148	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactctgctgtggaagtcctGaagaaatctgggaaagctac	12	9	11	9	0	2	2	0	1	2	1	3	4	3	4	1	2	3	2	1	2	5	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:164727148G>A	uc003fei.2	-	35	4160	c.4098C>T	c.(4096-4098)TTC>TTT	p.F1366F		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1366	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGGAAGTCCTGAAGAAATCTG	0.378										HNSCC(35;0.089)			60	46					0	0	0	0	A	164727148	A	A	164727148	2	1	244	1	0	0	0	0	0	0	0	1	14362	1281	45	2		2	SI	3	164727148	Silent	SNP	G	TCGA-CV-7261-01A-11D-2012-08	21739394	164727148	33295282	35	44831											
PIK3CA	5290	broad.mit.edu	37	chr3	178922325	178922325	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtatctaccatggaggagAacccttatgtgacaatgtga	13	10	11	7	0	1	3	0	2	1	1	1	5	1	4	2	3	2	1	2	3	5	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:178922325A>T	uc003fjk.2	+	6	1251	c.1094A>T	c.(1093-1095)GAA>GTA	p.E365V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	365	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E365K(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CATGGAGGAGAACCCTTATGT	0.343		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			40	122					0	0	0	0	T	178922325	T	T	178922325	3	4	244	1	0	0	0	0	1	0	0	0	11968	246	9	5	1112	5	PIK3CA	3	178922325	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08	14195177	178922325	19100105	36	44832											
MAP6D1	79929	broad.mit.edu	37	chr3	183535795	183535795	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctgacctggaagccggccCcagggctgctgtcccatccc	5	6	13	17	1	0	1	0	1	0	0	2	2	2	2	6	4	2	3	6	4	1	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:183535795C>T	uc003fmc.2	-	2	564	c.506G>A	c.(505-507)GGG>GAG	p.G169E		NM_024871	NP_079147	Q9H9H5	MA6D1_HUMAN	MAP6 domain containing 1	169						cytoskeleton					0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;5.15e-42)|Epithelial(37;4.29e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GAAGCCGGCCCCAGGGCTGCT	0.567													78	78					0	0	0	0	T	183535795	T	T	183535795	3	4	244	1	0	0	0	0	1	0	0	0	9318	623	22	4	101	4	MAP6D1	3	183535795	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	4613470	183535795	14486635	37	44833											
ATP13A4	84239	broad.mit.edu	37	chr3	193171990	193171990	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatctgaagttcgctaacaaAactagtgggtactgtttaga	14	12	9	6	1	1	2	0	1	1	1	2	2	1	2	0	1	3	4	0	1	8	6			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr3:193171990A>C	uc003ftd.2	-	17	2035	c.1927T>G	c.(1927-1929)TTT>GTT	p.F643V	ATP13A4_uc003fte.1_Missense_Mutation_p.F643V|ATP13A4_uc011bsr.1_Missense_Mutation_p.F114V|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	643	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TCGCTAACAAAACTAGTGGGT	0.433													8	89					0	0	0	0	C	193171990	C	C	193171990	3	2	244	1	0	0	0	0	1	0	0	0	1128	14	1	5	1719	5	ATP13A4	3	193171990	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08	9636195	193171990	4850440	38	44834											
UGT2A1	10941	broad.mit.edu	37	chr4	70513428	70513428	+	5'Flank	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttctctgcttttaaagaaAaaaaggaaagacaaaattat	19	13	5	4	0	1	2	0	0	1	2	2	3	1	3	0	1	1	1	0	1	9	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr4:70513428A>G	uc003hem.3	-						UGT2A1_uc011caq.1_Intron|UGT2A1_uc010ihu.2_Intron|UGT2A1_uc010iht.2_5'UTR	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,						detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						TTTTAAAGAAAAAAAGGAAAG	0.333													5	4					0	0	0	0	G	70513428	G	G	70513428	1	3	244	0	1	0	0	0	0	0	0	0	17021	29	1	5		5	UGT2A1	4	70513428	5'Flank	SNP	A	TCGA-CV-7261-01A-11D-2012-08		70513428	120640848	39	44835											
CFI	3426	broad.mit.edu	37	chr4	110687902	110687902	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccatggctggcagaagaCtttatcgcaggagaggtgag	10	8	15	8	1	0	4	0	1	0	3	1	5	0	4	1	4	1	3	1	4	2	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr4:110687902C>T	uc003hzr.3	-	2	344	c.136G>A	c.(136-138)GTC>ATC	p.V46I	CFI_uc011cft.1_Missense_Mutation_p.V46I|CFI_uc003hzs.3_Missense_Mutation_p.V46I	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	46					complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		TGGCAGAAGACTTTATCGCAG	0.428													4	46					0	0	0	0	T	110687902	T	T	110687902	3	4	244	1	0	0	0	0	1	0	0	0	3304	565	20	4	1663	4	CFI	4	110687902	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	40174474	110687902	80466374	40	44836											
KLKB1	3818	broad.mit.edu	37	chr4	187155200	187155200	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attccttgaagcaatgtggtCatcaaataagtggtaagttg	13	13	10	5	0	2	1	2	1	0	0	3	1	3	1	1	2	1	3	1	2	5	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr4:187155200C>T	uc003iyy.2	+	4	387	c.316C>T	c.(316-318)CAT>TAT	p.H106Y	KLKB1_uc011clc.1_5'UTR|KLKB1_uc011cld.1_Missense_Mutation_p.H68Y	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	106					blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GCAATGTGGTCATCAAATAAG	0.383													6	30					0	0	0	0	T	187155200	T	T	187155200	3	4	244	1	0	0	0	0	1	0	0	0	8451	826	29	2	326	2	KLKB1	4	187155200	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	76467298	187155200	3999076	41	44837											
HCN1	348980	broad.mit.edu	37	chr5	45262058	45262058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatcgtggcttttctgcgtCtgggtctgtgtttaagactg	6	16	12	7	2	3	1	0	0	3	1	4	1	3	1	0	2	1	2	0	2	2	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr5:45262058C>T	uc003jok.2	-	8	2663	c.2638G>A	c.(2638-2640)GAC>AAC	p.D880N		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	880	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTTTCTGCGTCTGGGTCTGTG	0.483													7	161					0	0	0	0	T	45262058	T	T	45262058	3	4	244	1	0	0	0	0	1	0	0	0	7035	913	32	2	38	2	HCN1	5	45262058	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08		45262058	135653202	42	44838											
GABRG2	2566	broad.mit.edu	37	chr5	161580208	161580208	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagtgtctggacggcaaggActgtgccagttttttctgct	6	14	13	8	1	2	1	0	1	2	0	2	3	2	3	1	3	2	3	1	3	1	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr5:161580208A>G	uc003lyz.3	+	9	1596	c.1238A>G	c.(1237-1239)GAC>GGC	p.D413G	GABRG2_uc010jjc.2_Missense_Mutation_p.D461G|GABRG2_uc003lyy.3_Missense_Mutation_p.D421G|GABRG2_uc011dej.1_Missense_Mutation_p.D318G	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	413	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GACGGCAAGGACTGTGCCAGT	0.458													10	61					0	0	0	0	G	161580208	G	G	161580208	3	3	244	1	0	0	0	0	1	0	0	0	6206	275	10	5	1424	5	GABRG2	5	161580208	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08	116318150	161580208	19335052	43	44839											
ZNF192	7745	broad.mit.edu	37	chr6	28121094	28121095	+	Missense_Mutation	DNP	GG	TT	TT																															gccactggagaatccacactGgggagaaaccctatcagtgt																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr6:28121094_28121095GG>TT	uc003nkn.1	+	6	1220_1221	c.1036_1037GG>TT	c.(1036-1038)GGG>TTG	p.G346L	ZNF192_uc010jqx.1_Missense_Mutation_p.G346L|ZNF192_uc010jqy.1_Missense_Mutation_p.G159L|ZNF192_uc011dkz.1_Missense_Mutation_p.G159L	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	346					viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AATCCACACTGGGGAGAAACCC	0.47													6	213					0	0	0	0	TT	28121095	TT	TT	28121094	3	4	244	1	0	0	0	0	1	0	0	0	17823	1348	47	4	1054	4	ZNF192	6	28121094	Missense_Mutation	DNP	GG	TCGA-CV-7261-01A-11D-2012-08		28121094	142993973	44	44840											
TREML2	79865	broad.mit.edu	37	chr6	41166104	41166104	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagcccttataggagcacTgcacagacagagtctcccct	10	9	9	13	0	1	2	0	0	1	2	2	3	1	3	3	1	3	3	3	1	3	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr6:41166104T>G	uc010jxm.1	-	2	298	c.119A>C	c.(118-120)CAG>CCG	p.Q40P		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	40	Ig-like V-type.|Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					ATAGGAGCACTGCACAGACAG	0.502													8	169					0	0	0	0	G	41166104	G	G	41166104	3	3	244	1	0	0	0	0	1	0	0	0	16540	1580	55	5	862	5	TREML2	6	41166104	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08	13045010	41166104	129948963	45	44841											
GABRR1	2569	broad.mit.edu	37	chr6	89926972	89926972	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccgggccagtgcattctgcTttcagtggccaaaacccatc	8	10	9	14	1	2	0	1	0	1	0	4	0	3	0	4	2	3	2	4	2	2	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr6:89926972T>A	uc003pna.2	-	1	525	c.70A>T	c.(70-72)AGC>TGC	p.S24C	GABRR1_uc011dzv.1_Missense_Mutation_p.S18C|GABRR1_uc011dzw.1_RNA	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	24	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	TGCATTCTGCTTTCAGTGGCC	0.463													11	34					0	0	0	0	A	89926972	A	A	89926972	3	1	244	1	0	0	0	0	1	0	0	0	6210	1609	56	5	1409	5	GABRR1	6	89926972	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08	48760868	89926972	81188095	46	44842											
HEY2	23493	broad.mit.edu	37	chr6	126080846	126080846	+	Silent	SNP	C	T	T																															gccgcggccacagccatcagCccgcccttgtcagtatcagc																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr6:126080846C>T	uc003qad.2	+	5	1103	c.912C>T	c.(910-912)AGC>AGT	p.S304S	HEY2_uc011ebr.1_Silent_p.S258S	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	304					negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		CAGCCATCAGCCCGCCCTTGT	0.607													56	103					0	0	0	0	T	126080846	T	T	126080846	2	4	244	1	0	0	0	0	0	0	0	1	7118	738	26	4		4	HEY2	6	126080846	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	36153874	126080846	45034221	47	44843	94	2									
HEY2	23493	broad.mit.edu	37	chr6	126080849	126080849	+	Silent	SNP	G	T	T																															gcggccacagccatcagcccGcccttgtcagtatcagccac																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr6:126080849G>T	uc003qad.2	+	5	1106	c.915G>T	c.(913-915)CCG>CCT	p.P305P	HEY2_uc011ebr.1_Silent_p.P259P	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	305					negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		CCATCAGCCCGCCCTTGTCAG	0.597													54	103					4.6707e-30	3.68848e-29	1	0	T	126080849	T	T	126080849	2	4	244	1	0	0	0	0	0	0	0	1	7118	1074	38	3		3	HEY2	6	126080849	Silent	SNP	G	TCGA-CV-7261-01A-11D-2012-08	3	126080849	45034218	48	44844	94	2									
EYA4	2070	broad.mit.edu	37	chr6	133783512	133783512	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacaccagcagctcaaacAatgtctgcctatgcaggcca	12	8	7	14	0	3	0	1	0	2	0	3	0	3	0	3	1	6	3	3	1	4	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr6:133783512A>G	uc003qec.3	+	8	935	c.477A>G	c.(475-477)ACA>ACG	p.T159T	EYA4_uc011ecq.1_Silent_p.T105T|EYA4_uc011ecr.1_Silent_p.T105T|EYA4_uc003qed.3_Silent_p.T159T|EYA4_uc003qee.3_Silent_p.T136T|EYA4_uc011ecs.1_Silent_p.T159T|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	159					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CAGCTCAAACAATGTCTGCCT	0.478													27	98					0	0	0	0	G	133783512	G	G	133783512	2	3	244	1	0	0	0	0	0	0	0	1	5356	117	5	5		5	EYA4	6	133783512	Silent	SNP	A	TCGA-CV-7261-01A-11D-2012-08	7702663	133783512	37331555	49	44845											
STX11	8676	broad.mit.edu	37	chr6	144508185	144508185	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgctcaccctcaccttccagCgcgccatgcacgactacaac	9	6	6	20	4	2	0	2	0	0	0	3	1	3	0	4	0	4	2	4	0	2	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr6:144508185C>A	uc003qks.3	+	2	613	c.421C>A	c.(421-423)CGC>AGC	p.R141S		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	141					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		CACCTTCCAGCGCGCCATGCA	0.657									Familial_Hemophagocytic_Lymphohistiocytosis				13	28					0.00136819	0.00912696	1	0	A	144508185	A	A	144508185	3	1	244	1	0	0	0	0	1	0	0	0	15403	768	27	3	423	3	STX11	6	144508185	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	10724673	144508185	26606882	50	44846											
STARD3NL	83930	broad.mit.edu	37	chr7	38247206	38247206	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcaaccccacacaactcaTggccaggattgagtcctatg	12	8	7	14	0	2	1	2	1	0	0	3	2	3	2	4	2	2	0	4	2	3	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr7:38247206T>A	uc003tfr.2	+	2	249	c.101T>A	c.(100-102)ATG>AAG	p.M34K	STARD3NL_uc003tfs.2_Missense_Mutation_p.M34K|STARD3NL_uc003tft.2_Missense_Mutation_p.M34K	NM_032016	NP_114405	O95772	MENTO_HUMAN	MLN64 N-terminal homolog	34	Cytoplasmic (Potential).					integral to membrane|late endosome membrane				ovary(1)	1						ACACAACTCATGGCCAGGATT	0.483													39	23					0	0	0	0	A	38247206	A	A	38247206	3	1	244	1	0	0	0	0	1	0	0	0	15324	1464	51	5	103	5	STARD3NL	7	38247206	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08		38247206	120891457	51	44847											
GLI3	2737	broad.mit.edu	37	chr7	42065866	42065866	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgtagggatccctggaatagGcctctgtgttggaaaagttg	9	11	14	7	1	1	0	0	0	1	0	2	3	2	3	2	4	0	3	2	4	5	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr7:42065866G>T	uc011kbh.1	-	8	1265	c.1174C>A	c.(1174-1176)CCT>ACT	p.P392T	GLI3_uc011kbg.1_Missense_Mutation_p.P333T	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	392					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CCTGGAATAGGCCTCTGTGTT	0.587									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				10	10					4.68919e-08	3.42598e-07	1	0	T	42065866	T	T	42065866	3	4	244	1	0	0	0	0	1	0	0	0	6476	1203	42	4	3600	4	GLI3	7	42065866	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	3818660	42065866	117072797	52	44848											
POM121L12	285877	broad.mit.edu	37	chr7	53104106	53104106	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccctggagcctcagttttTgtgatgatgcttggccttcc	4	14	11	12	0	1	2	1	2	0	0	2	3	2	3	5	2	2	2	5	2	0	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr7:53104106T>G	uc003tpz.2	+	1	758	c.742T>G	c.(742-744)TGT>GGT	p.C248G		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	248											0						CCTCAGTTTTTGTGATGATGC	0.632													5	60					0	0	0	0	G	53104106	G	G	53104106	3	3	244	1	0	0	0	0	1	0	0	0	12296	1812	63	5	744	5	POM121L12	7	53104106	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08	11038240	53104106	106034557	53	44849											
GRM3	2913	broad.mit.edu	37	chr7	86394698	86394698	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtttgctattgatgaaatCaacaaagatgattacttgct	13	16	7	5	0	1	4	1	3	0	1	1	4	1	4	0	0	4	3	0	0	5	6			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr7:86394698C>T	uc003uid.2	+	2	1336	c.237C>T	c.(235-237)ATC>ATT	p.I79I	GRM3_uc010lef.2_Silent_p.I77I|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	79	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TTGATGAAATCAACAAAGATG	0.423													48	120					0	0	0	0	T	86394698	T	T	86394698	2	4	244	1	0	0	0	0	0	0	0	1	6837	816	29	2		2	GRM3	7	86394698	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	33290592	86394698	72743965	54	44850											
ABCB4	5244	broad.mit.edu	37	chr7	87037431	87037431	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacagccactgctgcccacCagggctagtgtctggccttt	6	9	10	16	0	1	0	0	0	1	0	1	0	1	0	5	2	3	2	5	2	1	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr7:87037431C>A	uc003uiv.1	-	25	3277	c.3201G>T	c.(3199-3201)CTG>CTT	p.L1067L	ABCB4_uc003uiw.1_Silent_p.L1067L|ABCB4_uc003uix.1_Silent_p.L1020L	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	1067	ABC transporter 2.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TGCTGCCCACCAGGGCTAGTG	0.562													36	112					4.11147e-13	3.10966e-12	1	0	A	87037431	A	A	87037431	2	1	244	1	0	0	0	0	0	0	0	1	43	581	21	4		4	ABCB4	7	87037431	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	642733	87037431	72101232	55	44851											
ABCB4	5244	broad.mit.edu	37	chr7	87069068	87069068	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagaaggatcttggggttgCgaaccagggcacgtgcaatg	10	7	16	8	2	1	1	0	0	1	1	1	3	1	2	1	4	3	4	1	4	3	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr7:87069068C>A	uc003uiv.1	-	14	1722	c.1646G>T	c.(1645-1647)CGC>CTC	p.R549L	ABCB4_uc003uiw.1_Missense_Mutation_p.R549L|ABCB4_uc003uix.1_Missense_Mutation_p.R549L	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	549	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CTTGGGGTTGCGAACCAGGGC	0.532													8	131					0.000274275	0.00187625	1	0	A	87069068	A	A	87069068	3	1	244	1	0	0	0	0	1	0	0	0	43	768	27	3	2274	3	ABCB4	7	87069068	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	31637	87069068	72069595	56	44852											
PIK3CG	5294	broad.mit.edu	37	chr7	106508169	106508169	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgcaaatgcaagagccccGaaacggcgctgctgcacgtg	11	4	13	13	5	0	1	0	0	0	1	0	2	0	1	2	1	6	5	2	1	3	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr7:106508169G>A	uc003vdv.3	+	2	248	c.163G>A	c.(163-165)GAA>AAA	p.E55K	PIK3CG_uc003vdu.2_Missense_Mutation_p.E55K|PIK3CG_uc003vdw.2_Missense_Mutation_p.E55K	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	55					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CAAGAGCCCCGAAACGGCGCT	0.667													32	44					0	0	0	0	A	106508169	A	A	106508169	3	1	244	1	0	0	0	0	1	0	0	0	11971	1059	37	1	165	1	PIK3CG	7	106508169	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	19439101	106508169	52630494	57	44853											
OR9A2	135924	broad.mit.edu	37	chr7	142724094	142724094	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacaatcacaatgatgacCgtgtttcccattaatgtcac	13	11	6	11	1	2	3	2	2	0	1	3	3	3	3	2	0	0	1	2	0	3	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr7:142724094C>T	uc003wcc.1	-	1	126	c.126G>A	c.(124-126)ACG>ACA	p.T42T		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					CAATGATGACCGTGTTTCCCA	0.443													13	130					0	0	0	0	T	142724094	T	T	142724094	2	4	244	1	0	0	0	0	0	0	0	1	11302	639	23	1		1	OR9A2	7	142724094	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	36215925	142724094	16414569	58	44854											
GBX1	2636	broad.mit.edu	37	chr7	150846025	150846025	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacccctgctgtcaccggtGccccctcctcagctccagtc	4	9	8	20	1	2	1	2	1	0	0	5	1	4	1	7	1	3	2	7	1	0	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr7:150846025G>T	uc011kvg.1	-	2	975	c.743C>A	c.(742-744)GCA>GAA	p.A248E		NM_001098834	NP_001092304	Q14549	GBX1_HUMAN	gastrulation brain homeo box 1	248						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGTCACCGGTGCCCCCTCCTC	0.597													15	161					1.52009e-12	1.14166e-11	1	0	T	150846025	T	T	150846025	3	4	244	1	0	0	0	0	1	0	0	0	6315	1319	46	4	351	4	GBX1	7	150846025	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	8121931	150846025	8292638	59	44855											
ADAM2	2515	broad.mit.edu	37	chr8	39624380	39624380	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaatacctttgccaaatgtGtctgtacattgtttatcccc	10	16	5	10	0	1	0	0	0	1	0	2	0	2	0	4	0	3	2	4	0	6	7			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr8:39624380G>A	uc003xnj.2	-	14	1569	c.1494C>T	c.(1492-1494)GAC>GAT	p.D498D	ADAM2_uc003xnk.2_Silent_p.D479D|ADAM2_uc011lck.1_Silent_p.D498D|ADAM2_uc003xnl.2_Silent_p.D372D	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	498	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TGCCAAATGTGTCTGTACATT	0.363													10	71					0	0	0	0	A	39624380	A	A	39624380	2	1	244	1	0	0	0	0	0	0	0	1	241	1368	48	4		4	ADAM2	8	39624380	Silent	SNP	G	TCGA-CV-7261-01A-11D-2012-08		39624380	106739642	60	44856											
RP1	6101	broad.mit.edu	37	chr8	55534743	55534743	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cggcaggaagggagccatttAaaccaggaaattatgacatc	15	7	11	8	1	0	1	0	1	0	0	1	4	0	4	2	4	2	1	2	4	5	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr8:55534743A>T	uc003xsd.1	+	3	830	c.682A>T	c.(682-684)AAA>TAA	p.K228*	RP1_uc011ldy.1_Nonsense_Mutation_p.K228*	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	228	Doublecortin 2.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGAGCCATTTAAACCAGGAAA	0.493													12	21					0	0	0	0	T	55534743	T	T	55534743	4	4	244	1	0	0	0	0	0	1	0	0	13597	363	13	5	688	5	RP1	8	55534743	Nonsense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08	15910363	55534743	90829279	61	44857											
PEX2	5828	broad.mit.edu	37	chr8	77896342	77896342	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgctccagggccttgtttaGttcaagtgcatccaactggc	7	12	10	12	0	1	0	1	0	0	0	3	0	3	0	3	2	3	4	3	2	3	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr8:77896342G>T	uc003yax.2	-	4	531	c.73C>A	c.(73-75)CTA>ATA	p.L25I	PEX2_uc003yay.2_Missense_Mutation_p.L25I|PEX2_uc003yaz.2_Missense_Mutation_p.L25I	NM_000318	NP_000309	P28328	PEX2_HUMAN	peroxin 2	25					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			ovary(1)	1						GCCTTGTTTAGTTCAAGTGCA	0.458													6	87					3.59834e-05	0.000252589	1	0	T	77896342	T	T	77896342	3	4	244	1	0	0	0	0	1	0	0	0	11800	1020	36	4	848	4	PEX2	8	77896342	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	22361599	77896342	68467680	62	44858											
LRRCC1	85444	broad.mit.edu	37	chr8	86027454	86027454	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagctgcagtgcctagaaGgtcttttggataatttagtt	10	14	10	7	0	1	1	0	0	1	1	1	2	1	2	1	2	3	3	1	2	4	7			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr8:86027454G>A	uc003ycw.2	+	5	818	c.664G>A	c.(664-666)GGT>AGT	p.G222S	LRRCC1_uc010lzz.1_Intron|LRRCC1_uc010maa.1_Intron|LRRCC1_uc003ycx.2_Missense_Mutation_p.G129S|LRRCC1_uc003ycy.2_Missense_Mutation_p.G202S	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	222					cell division|mitosis	centriole|nucleus					0						GTGCCTAGAAGGTCTTTTGGA	0.328													27	42					0	0	0	0	A	86027454	A	A	86027454	3	1	244	1	0	0	0	0	1	0	0	0	9076	1000	35	4	682	4	LRRCC1	8	86027454	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	8131112	86027454	60336568	63	44859											
DCAF4L2	138009	broad.mit.edu	37	chr8	88885295	88885295	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtactgtgttacacatttaGtggccctcaagtcccacagc	9	11	8	13	1	1	0	1	0	0	0	2	0	2	0	2	1	3	2	2	1	4	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr8:88885295G>A	uc003ydz.2	-	1	1002	c.905C>T	c.(904-906)ACT>ATT	p.T302I		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	302	WD 1.									ovary(1)	1						TACACATTTAGTGGCCCTCAA	0.512													21	29					0	0	0	0	A	88885295	A	A	88885295	3	1	244	1	0	0	0	0	1	0	0	0	4289	1029	36	4	286	4	DCAF4L2	8	88885295	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	2857841	88885295	57478727	64	44860											
FAM135B	51059	broad.mit.edu	37	chr8	139190886	139190886	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgggacgtgagccaggcCagatccttgcttatctgctc	7	11	12	11	1	1	2	0	1	1	1	3	3	2	3	3	2	3	2	3	2	1	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr8:139190886C>A	uc003yuy.2	-	10	1092	c.921G>T	c.(919-921)CTG>CTT	p.L307L	FAM135B_uc003yux.2_Silent_p.L208L|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	307										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGAGCCAGGCCAGATCCTTGC	0.512										HNSCC(54;0.14)			16	31					7.07596e-05	0.000493479	1	0	A	139190886	A	A	139190886	2	1	244	1	0	0	0	0	0	0	0	1	5477	581	21	4		4	FAM135B	8	139190886	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	50305591	139190886	7173136	65	44861											
KIFC2	90990	broad.mit.edu	37	chr8	145694974	145694974	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccacctgctaccgggggCgccatcgtcgattccgccta	6	8	10	17	5	1	0	1	0	0	0	4	1	2	0	6	2	2	1	6	2	2	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr8:145694974C>T	uc003zcz.2	+	12	1389	c.1324C>T	c.(1324-1326)CGC>TGC	p.R442C	KIFC2_uc003zda.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	442	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTACCGGGGGCGCCATCGTCG	0.612													9	38					0	0	0	0	T	145694974	T	T	145694974	3	4	244	1	0	0	0	0	1	0	0	0	8352	768	27	1	1370	1	KIFC2	8	145694974	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	6504088	145694974	669048	66	44862											
PDCL	5082	broad.mit.edu	37	chr9	125585307	125585307	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaattaccttcccactgatCttctcctggaggtctttctg	6	16	6	13	0	4	1	0	1	4	0	6	2	5	2	3	2	1	0	3	2	2	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr9:125585307C>T	uc004bmz.1	-	3	438	c.342G>A	c.(340-342)AAG>AAA	p.K114K	PDCL_uc004bna.2_Silent_p.K114K	NM_005388	NP_005379	Q13371	PHLP_HUMAN	phosducin-like	114					signal transduction|visual perception						0						TCCCACTGATCTTCTCCTGGA	0.493													5	147					0	0	0	0	T	125585307	T	T	125585307	2	4	244	1	0	0	0	0	0	0	0	1	11680	912	32	2		2	PDCL	9	125585307	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08		125585307	15628124	67	44863											
GOLGA2	2801	broad.mit.edu	37	chr9	131022971	131022971	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgtcttgcacctgggcttGaagctgtcctgccagaccct	6	12	10	13	0	1	2	0	1	1	1	2	2	2	2	4	1	3	3	4	1	1	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr9:131022971G>A	uc011maw.1	-	17	1463	c.1450C>T	c.(1450-1452)CAA>TAA	p.Q484*	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004buh.2_5'UTR|uc004bun.2_5'Flank	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	484	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						ACCTGGGCTTGAAGCTGTCCT	0.682													23	54					0	0	0	0	A	131022971	A	A	131022971	4	1	244	1	0	0	0	0	0	1	0	0	6589	1299	45	2	1598	2	GOLGA2	9	131022971	Nonsense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	5437664	131022971	10190460	68	44864											
SET	6418	broad.mit.edu	37	chr9	131456200	131456200	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cgatatggatgatgaagaagGagaaggagaagaagatgatg	18	6	16	1	1	0	8	0	3	0	5	0	12	0	9	0	3	0	0	0	3	6	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr9:131456200G>C	uc004bvt.3	+	7	969	c.728G>C	c.(727-729)GGA>GCA	p.G243A	SET_uc004bvu.3_Missense_Mutation_p.G230A|SET_uc010myg.2_RNA|SET_uc011mbj.1_Missense_Mutation_p.G219A	NM_001122821	NP_001116293	Q01105	SET_HUMAN	SET translocation (myeloid leukemia-associated)	243	Asp/Glu-rich (highly acidic).				DNA replication|mRNA metabolic process|negative regulation of histone acetylation|negative regulation of neuron apoptosis|negative regulation of transcription, DNA-dependent|nucleocytoplasmic transport|nucleosome assembly|nucleosome disassembly	cytosol|endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm|protein complex	histone binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0		Myeloproliferative disorder(178;0.204)		GBM - Glioblastoma multiforme(294;3.1e-09)		GATgaagaaggagaaggagaa	0.149			T	NUP214	AML								6	39					0	0	0	0	C	131456200	C	C	131456200	3	2	244	1	0	0	0	0	1	0	0	0	14193	1174	41	2	831	2	SET	9	131456200	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	433229	131456200	9757231	69	44865											
OBP2B	29989	broad.mit.edu	37	chr9	136081795	136081795	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctcccggttggtatcagAattcctacctgcaggtgagg	7	10	13	11	1	1	2	1	1	0	1	3	2	3	2	4	5	2	3	4	5	3	4	rs1132279		TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr9:136081795A>G	uc004ccz.2	-	5	439	c.397T>C	c.(397-399)TCT>CCT	p.S133P	OBP2B_uc010nad.2_RNA|OBP2B_uc011mcy.1_Missense_Mutation_p.S65P	NM_014581	NP_055396	Q9NPH6	OBP2B_HUMAN	odorant binding protein 2B precursor	133					chemosensory behavior|sensory perception of smell	extracellular region	odorant binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.41e-06)|Epithelial(140;1.88e-05)		TTGGTATCAGAATTCCTACCT	0.612													3	46					0	0	0	0	G	136081795	G	G	136081795	3	3	244	1	0	0	0	0	1	0	0	0	10865	246	9	5	123	5	OBP2B	9	136081795	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08	4625595	136081795	5131636	70	44866											
SARDH	1757	broad.mit.edu	37	chr9	136573442	136573442	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctctcctcatgttgcgcccGgccagcggctcatcgtgggg	3	10	13	15	4	3	0	2	0	1	0	6	0	4	0	3	4	2	2	3	4	0	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr9:136573442G>A	uc004cep.3	-	11	1571	c.1437C>T	c.(1435-1437)GCC>GCT	p.A479A	SARDH_uc004ceo.2_Silent_p.A479A|SARDH_uc011mdn.1_Silent_p.A479A|SARDH_uc011mdo.1_Silent_p.A311A	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	479					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGTTGCGCCCGGCCAGCGGCT	0.657													7	73					0	0	0	0	A	136573442	A	A	136573442	2	1	244	1	0	0	0	0	0	0	0	1	13906	1103	39	1		1	SARDH	9	136573442	Silent	SNP	G	TCGA-CV-7261-01A-11D-2012-08	491647	136573442	4639989	71	44867											
MYO3A	53904	broad.mit.edu	37	chr10	26462739	26462739	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accaatgctgtggagagtaaCaacagagtgtatcagactcc	14	8	10	9	0	1	3	1	0	0	3	2	4	2	3	2	1	3	3	2	1	4	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr10:26462739C>G	uc001isn.2	+	30	3906	c.3546C>G	c.(3544-3546)AAC>AAG	p.N1182K	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1182					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TGGAGAGTAACAACAGAGTGT	0.388													8	42					0	0	0	0	G	26462739	G	G	26462739	3	3	244	1	0	0	0	0	1	0	0	0	10129	477	17	4	3656	4	MYO3A	10	26462739	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08		26462739	109072008	72	44868											
SUPV3L1	6832	broad.mit.edu	37	chr10	70951445	70951445	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggtgacaggtgaagagcGtgtgacagttcagccaaatg	11	9	14	7	1	1	4	1	3	0	1	1	4	1	4	1	2	2	1	1	2	2	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr10:70951445G>T	uc001jpe.1	+	6	831	c.776G>T	c.(775-777)CGT>CTT	p.R259L	SUPV3L1_uc010qjd.1_Missense_Mutation_p.R128L	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	259	Helicase ATP-binding.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						GGTGAAGAGCGTGTGACAGTT	0.368													12	49					2.31682e-05	0.000163702	1	0	T	70951445	T	T	70951445	3	4	244	1	0	0	0	0	1	0	0	0	15468	1145	40	3	798	3	SUPV3L1	10	70951445	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	44488706	70951445	64583302	73	44869											
SH2D4B	387694	broad.mit.edu	37	chr10	82329963	82329963	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcagatggcgaggtctggGtctggatcatgggagaaggc	8	7	20	6	1	3	2	1	0	2	2	3	5	3	3	0	7	0	1	0	7	1	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr10:82329963G>T	uc001kck.1	+	2	668	c.238G>T	c.(238-240)GTC>TTC	p.V80F	SH2D4B_uc001kcl.1_Missense_Mutation_p.V31F	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	79											0			Colorectal(32;0.229)			CGAGGTCTGGGTCTGGATCAT	0.532													31	45					2.85442e-18	2.2055e-17	1	0	T	82329963	T	T	82329963	3	4	244	1	0	0	0	0	1	0	0	0	14301	1261	44	4	285	4	SH2D4B	10	82329963	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	11378518	82329963	53204784	74	44870											
PLEKHA1	59338	broad.mit.edu	37	chr10	124189449	124189449	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagccttccggtcagtgacGtgtgaggcagaagcgcacgg	8	6	16	11	5	1	3	1	2	0	1	2	4	2	3	2	3	2	2	2	3	1	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr10:124189449G>A	uc001lge.1	+	12	1333	c.1210G>A	c.(1210-1212)GTG>ATG	p.V404M	PLEKHA1_uc001lgf.1_3'UTR|PLEKHA1_uc001lgg.1_Missense_Mutation_p.V404M	NM_001001974	NP_001001974	Q9HB21	PKHA1_HUMAN	pleckstrin homology domain containing, family A	404					B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			kidney(1)	1		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGTCAGTGACGTGTGAGGCAG	0.498													9	38					0	0	0	0	A	124189449	A	A	124189449	3	1	244	1	0	0	0	0	1	0	0	0	12110	1145	40	1	1252	1	PLEKHA1	10	124189449	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	41859486	124189449	11345298	75	44871											
MKI67	4288	broad.mit.edu	37	chr10	129903164	129903164	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgaagccagccaggtcttCtagagcctgggccttttcct	6	13	10	12	0	2	2	0	1	2	1	3	2	3	2	5	2	3	0	5	2	2	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr10:129903164C>G	uc001lke.2	-	13	7135	c.6940G>C	c.(6940-6942)GAA>CAA	p.E2314Q	MKI67_uc001lkf.2_Missense_Mutation_p.E1954Q|MKI67_uc009yav.1_Missense_Mutation_p.E1889Q|MKI67_uc009yaw.1_Missense_Mutation_p.E1464Q	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2314	16 X 122 AA approximate repeats.|11.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GCCAGGTCTTCTAGAGCCTGG	0.493													63	269					0	0	0	0	G	129903164	G	G	129903164	3	3	244	1	0	0	0	0	1	0	0	0	9651	922	32	2	2842	2	MKI67	10	129903164	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	5713715	129903164	5631583	76	44872											
OR52N4	390072	broad.mit.edu	37	chr11	5776833	5776833	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tatttatctgctcctaccacCcactatgaaccctattgtct	9	15	3	14	0	2	1	0	1	2	0	3	1	3	1	4	0	3	1	4	0	6	7			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:5776833C>A	uc001mbu.2	+	1	911	c.863C>A	c.(862-864)CCC>CAC	p.P288H	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CTCCTACCACCCACTATGAAC	0.448													41	31					6.2361e-21	4.88874e-20	1	0	A	5776833	A	A	5776833	3	1	244	1	0	0	0	0	1	0	0	0	11183	623	22	4	865	4	OR52N4	11	5776833	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08		5776833	129229683	77	44873											
HPX	3263	broad.mit.edu	37	chr11	6452915	6452915	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acccagggcagataaaggccGcatccacagagtccaggata	14	4	11	12	1	0	2	0	0	0	2	2	3	2	3	4	3	0	2	4	3	3	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:6452915G>A	uc001mdg.2	-	9	1146	c.1085C>T	c.(1084-1086)GCG>GTG	p.A362V	HPX_uc001mdf.2_Missense_Mutation_p.A108V|HPX_uc009yfc.2_RNA	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	362					cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		GATAAAGGCCGCATCCACAGA	0.557													38	24					0	0	0	0	A	6452915	A	A	6452915	3	1	244	1	0	0	0	0	1	0	0	0	7385	1087	38	1	311	1	HPX	11	6452915	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	676082	6452915	128553601	78	44874											
SYT9	143425	broad.mit.edu	37	chr11	7324589	7324589	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccatggcgtccgcgtgcaGcgccaagtcacagagccaac	9	4	12	16	4	1	1	1	0	0	1	2	1	2	1	4	1	4	1	4	1	2	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:7324589G>A	uc001mfe.2	+	2	702	c.465G>A	c.(463-465)CAG>CAA	p.Q155Q	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	155	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TCCGCGTGCAGCGCCAAGTCA	0.597													12	15					0	0	0	0	A	7324589	A	A	7324589	2	1	244	1	0	0	0	0	0	0	0	1	15547	962	34	4		4	SYT9	11	7324589	Silent	SNP	G	TCGA-CV-7261-01A-11D-2012-08	871674	7324589	127681927	79	44875											
MUC15	143662	broad.mit.edu	37	chr11	26587444	26587444	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtttttttttaaaggaatCtgaaagaaaataaccataat	17	15	6	3	0	1	2	0	1	1	1	1	3	1	3	1	2	1	1	1	2	8	7			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:26587444C>T	uc001mqx.2	-	2	229	c.-37_splice	c.e2-1		ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Splice_Site_p.Y15_splice|MUC15_uc001mqy.2_Splice_Site_p.Y15_splice	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b							extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTAAAGGAATCTGAAAGAAAA	0.274													9	32					0	0	0	0	T	26587444	T	T	26587444	5	4	244	1	0	0	0	0	0	0	1	0	10025	927	32	2	1054	2	MUC15	11	26587444	Splice_Site	SNP	C	TCGA-CV-7261-01A-11D-2012-08	19262855	26587444	108419072	80	44876											
KCNA4	3739	broad.mit.edu	37	chr11	30033487	30033487	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgaagatatcaaaggggaCattgactggcctcttcaggc	12	9	12	8	0	3	3	2	2	1	1	3	4	3	4	1	4	0	0	1	4	3	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:30033487C>A	uc001msk.2	-	2	1891	c.739G>T	c.(739-741)GTC>TTC	p.V247F		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	247						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCAAAGGGGACATTGACTGGC	0.498													6	118					5.18039e-06	3.70916e-05	1	0	A	30033487	A	A	30033487	3	1	244	1	0	0	0	0	1	0	0	0	8044	478	17	4	1226	4	KCNA4	11	30033487	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	3446043	30033487	104973029	81	44877											
OR4A15	81328	broad.mit.edu	37	chr11	55135451	55135451	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaccttcagaagaacacaTgaaaaataagaacaatgtga	22	6	6	7	0	1	5	1	2	0	3	1	5	1	5	1	0	3	0	1	0	8	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:55135451T>C	uc010rif.1	+	1	92	c.92T>C	c.(91-93)ATG>ACG	p.M31T		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	31	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M31I(1)		ovary(1)|skin(1)	2						GAAGAACACATGAAAAATAAG	0.383													8	47					0	0	0	0	C	55135451	C	C	55135451	3	2	244	1	0	0	0	0	1	0	0	0	11094	1464	51	5	94	5	OR4A15	11	55135451	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08	25101964	55135451	79871065	82	44878											
OR5I1	10798	broad.mit.edu	37	chr11	55703122	55703122	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggagagtcccttggtagAtcgtcactgaagtcaggtga	11	9	14	7	1	2	5	2	2	0	3	4	6	3	5	1	3	0	1	1	3	2	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:55703122A>G	uc010ris.1	-	1	755	c.755T>C	c.(754-756)ATC>ACC	p.I252T		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCCTTGGTAGATCGTCACTGA	0.428													5	17					0	0	0	0	G	55703122	G	G	55703122	3	3	244	1	0	0	0	0	1	0	0	0	11218	333	12	5	192	5	OR5I1	11	55703122	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08	567671	55703122	79303394	83	44879											
LPXN	9404	broad.mit.edu	37	chr11	58322350	58322350	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaggtgagccatgagctcAtccaactgagcagctgctga	10	8	12	11	0	2	4	2	4	0	0	3	4	3	4	2	1	6	4	2	1	1	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:58322350A>G	uc001nmw.2	-	4	427	c.282T>C	c.(280-282)GAT>GAC	p.D94D	LPXN_uc009ymp.2_5'UTR|LPXN_uc010rkj.1_Silent_p.D99D|LPXN_uc010rkk.1_Silent_p.D74D	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2	94	LD motif 3.				cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				CCATGAGCTCATCCAACTGAG	0.502													11	88					0	0	0	0	G	58322350	G	G	58322350	2	3	244	1	0	0	0	0	0	0	0	1	8979	214	8	5		5	LPXN	11	58322350	Silent	SNP	A	TCGA-CV-7261-01A-11D-2012-08	2619228	58322350	76684166	84	44880											
PITPNM1	9600	broad.mit.edu	37	chr11	67265032	67265032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcaggactggccatgtcgCtggggatgcgctggggaggc	5	7	19	10	2	1	0	1	0	0	0	2	3	1	3	1	7	1	3	1	7	0	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:67265032C>T	uc001olx.2	-	12	2090	c.1901G>A	c.(1900-1902)AGC>AAC	p.S634N	PITPNM1_uc001olw.2_5'UTR|PITPNM1_uc001oly.2_Missense_Mutation_p.S634N|PITPNM1_uc001olz.2_Missense_Mutation_p.S634N	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	634					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						GGCCATGTCGCTGGGGATGCG	0.672													11	118					0	0	0	0	T	67265032	T	T	67265032	3	4	244	1	0	0	0	0	1	0	0	0	12005	797	28	4	1881	4	PITPNM1	11	67265032	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	8942682	67265032	67741484	85	44881											
SERPINH1	871	broad.mit.edu	37	chr11	75280100	75280100	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcacgtggagcctctcgagCgccttgaaaagctgctaacc	10	8	10	13	3	2	1	1	1	1	0	3	3	2	2	3	1	5	2	3	1	3	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:75280100C>T	uc001owr.2	+	4	1067	c.838C>T	c.(838-840)CGC>TGC	p.R280C	SERPINH1_uc009yuf.2_Missense_Mutation_p.R280C|SERPINH1_uc009yug.2_Missense_Mutation_p.R280C|SERPINH1_uc001ows.2_Missense_Mutation_p.R280C|SERPINH1_uc001owt.2_Missense_Mutation_p.R63C	NM_001235	NP_001226	P50454	SERPH_HUMAN	serine (or cysteine) proteinase inhibitor, clade	280					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			ovary(2)	2	Ovarian(111;0.11)					GCCTCTCGAGCGCCTTGAAAA	0.562													27	33					0	0	0	0	T	75280100	T	T	75280100	3	4	244	1	0	0	0	0	1	0	0	0	14182	768	27	1	848	1	SERPINH1	11	75280100	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	8015068	75280100	59726416	86	44882											
KIAA1826	84437	broad.mit.edu	37	chr11	105880416	105880416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctcaagttttaacttctctGtttctatgtcctgtggttga	6	19	8	8	0	3	1	1	1	2	0	5	1	4	1	1	1	1	4	1	1	3	6			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:105880416G>A	uc001piy.2	-	3	1057	c.884C>T	c.(883-885)ACA>ATA	p.T295I	KIAA1826_uc001piz.2_Missense_Mutation_p.T295I	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	295	Potential.					nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		TAACTTCTCTGTTTCTATGTC	0.408													12	134					0	0	0	0	A	105880416	A	A	105880416	3	1	244	1	0	0	0	0	1	0	0	0	8299	1377	48	4	157	4	KIAA1826	11	105880416	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	30600316	105880416	29126100	87	44883											
FDXACB1	91893	broad.mit.edu	37	chr11	111746387	111746387	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggcaaaatgtggcacttCtgaaagacaggtccactgag	15	7	11	8	0	1	3	0	2	1	1	2	3	2	3	1	3	0	2	1	3	4	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr11:111746387C>A	uc001pmc.3	-	5	1431	c.1134G>T	c.(1132-1134)CAG>CAT	p.Q378H	ALG9_uc010rwo.1_Intron|FDXACB1_uc009yyi.2_Missense_Mutation_p.Q229H	NM_138378	NP_612387	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain	378					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0						TGTGGCACTTCTGAAAGACAG	0.443													13	213					0.00010058	0.000696921	1	0	A	111746387	A	A	111746387	3	1	244	1	0	0	0	0	1	0	0	0	5838	912	32	2	744	2	FDXACB1	11	111746387	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	5865971	111746387	23260129	88	44884											
AICDA	57379	broad.mit.edu	37	chr12	8757850	8757850	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatttgcaccccggcgcggtGcagccgccgcagcccctcgg	4	6	13	18	6	0	0	0	0	0	0	1	0	0	0	6	3	4	3	6	3	1	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr12:8757850G>A	uc001qur.2	-	3	467	c.388C>T	c.(388-390)CAC>TAC	p.H130Y	AICDA_uc001qup.1_Missense_Mutation_p.H125Y|AICDA_uc001quq.1_Missense_Mutation_p.H125Y|AICDA_uc009zgd.1_Intron	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	130					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					CCGGCGCGGTGCAGCCGCCGC	0.647									Immune_Deficiency_with_Hyper-IgM				22	23					0	0	0	0	A	8757850	A	A	8757850	3	1	244	1	0	0	0	0	1	0	0	0	422	1319	46	4	220	4	AICDA	12	8757850	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08		8757850	125094045	89	44885											
MLL2	8085	broad.mit.edu	37	chr12	49431982	49431983	+	Frame_Shift_Ins	INS	-	A	A																															gtgtccagctcaggatcagtINSatatgccagcaggtcaaact																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr12:49431982_49431983insA	uc001rta.3	-	34	9156_9157	c.9156_9157insT	c.(9154-9159)TATACTfs	p.Y3052fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3052_3053					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCAGGATCAGTATATGCCAGCA	0.52			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								A	49431983	A	A	49431982	7	5	244	1	0	1	1	0	0	0	0	0	9674	1638	57	0	7540	0	MLL2	12	49431982	Frame_Shift_Ins	INS	-	TCGA-CV-7261-01A-11D-2012-08	40674132	49431982	84419913	90	44886											
ERBB3	2065	broad.mit.edu	37	chr12	56478837	56478837	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatgaattctctactctacCattgcccaacctccgcgtgg	9	11	7	14	2	2	1	0	1	2	0	4	2	3	1	4	1	4	0	4	1	5	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr12:56478837C>G	uc001sjh.2	+	3	486	c.293C>G	c.(292-294)CCA>CGA	p.P98R	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.P39R|ERBB3_uc001sjg.2_Missense_Mutation_p.P98R	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	98	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TCTACTCTACCATTGCCCAAC	0.507													6	112					0	0	0	0	G	56478837	G	G	56478837	3	3	244	1	0	0	0	0	1	0	0	0	5232	594	21	4	303	4	ERBB3	12	56478837	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	7046855	56478837	77373058	91	44887											
ANKS1B	56899	broad.mit.edu	37	chr12	100173680	100173680	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgcaatctggagagatttCtgagatggatgttctttcag	9	15	12	5	0	4	2	1	1	3	2	4	6	4	4	0	2	1	3	0	2	1	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr12:100173680C>T	uc001tge.1	-	6	1233	c.816G>A	c.(814-816)CAG>CAA	p.Q272Q	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Intron	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	272						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GGAGAGATTTCTGAGATGGAT	0.343													31	64					0	0	0	0	T	100173680	T	T	100173680	2	4	244	1	0	0	0	0	0	0	0	1	689	912	32	2		2	ANKS1B	12	100173680	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	43694843	100173680	33678215	92	44888											
NALCN	259232	broad.mit.edu	37	chr13	101726002	101726002	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cggaacagtacggtaatagcTtttccagccgaagaaaaatt	15	9	9	8	3	0	1	0	0	0	1	1	3	1	2	2	2	4	3	2	2	7	6			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr13:101726002T>A	uc001vox.1	-	37	4320	c.4131A>T	c.(4129-4131)AAA>AAT	p.K1377N		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1377	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CGGTAATAGCTTTTCCAGCCG	0.353													4	26					0	0	0	0	A	101726002	A	A	101726002	3	1	244	1	0	0	0	0	1	0	0	0	10201	1606	56	5	1117	5	NALCN	13	101726002	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08		101726002	13443876	93	44889											
OR4K1	79544	broad.mit.edu	37	chr14	20404652	20404652	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttctttctgtgttctacaCtgtttgtactcccttgttga	5	21	6	9	0	3	1	0	1	3	0	4	1	4	1	1	0	2	4	1	0	2	8			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr14:20404652C>G	uc001vwj.1	+	1	827	c.827C>G	c.(826-828)ACT>AGT	p.T276S		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GTGTTCTACACTGTTTGTACT	0.428													10	332					0	0	0	0	G	20404652	G	G	20404652	3	3	244	1	0	0	0	0	1	0	0	0	11121	565	20	4	829	4	OR4K1	14	20404652	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08		20404652	86944888	94	44890											
LRP10	26020	broad.mit.edu	37	chr14	23346447	23346447	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggcacccccactgcccaTcaaggctcccctcccatctg	7	6	7	21	0	2	0	1	0	1	0	4	0	4	0	6	2	1	3	6	2	1	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr14:23346447T>C	uc001whd.2	+	7	2406	c.1853T>C	c.(1852-1854)ATC>ACC	p.I618T	LRP10_uc001whe.2_Intron	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	618	Pro-rich.|Cytoplasmic (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		CCACTGCCCATCAAGGCTCCC	0.657													7	156					0	0	0	0	C	23346447	C	C	23346447	3	2	244	1	0	0	0	0	1	0	0	0	9002	1435	50	5	1879	5	LRP10	14	23346447	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08	2941795	23346447	84003093	95	44891											
NIN	51199	broad.mit.edu	37	chr14	51237120	51237120	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattacctttaaagagagggCaaggcggtcccggatatagt	12	9	13	7	2	0	1	0	0	0	1	1	4	1	2	2	4	1	1	2	4	6	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr14:51237120C>A	uc001wym.2	-	12	1611	c.1420G>T	c.(1420-1422)GCC>TCC	p.A474S	NIN_uc001wyi.2_Missense_Mutation_p.A474S|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.A474S|NIN_uc010tqp.1_Missense_Mutation_p.A480S|NIN_uc001wyo.2_Missense_Mutation_p.A474S|NIN_uc001wyp.1_Missense_Mutation_p.A436S	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	474	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					AAAGAGAGGGCAAGGCGGTCC	0.483			T	PDGFRB	MPD								5	27					0.000602214	0.00409353	1	0	A	51237120	A	A	51237120	3	1	244	1	0	0	0	0	1	0	0	0	10471	710	25	4	5209	4	NIN	14	51237120	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	27890673	51237120	56112420	96	44892											
FUT8	2530	broad.mit.edu	37	chr14	66136078	66136078	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgattgcatatggcacccagCgaacactcatcttggaatct	11	11	8	11	1	3	1	1	1	2	0	3	3	3	2	1	2	3	2	1	2	3	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr14:66136078C>T	uc001xin.2	+	7	1912	c.715C>T	c.(715-717)CGA>TGA	p.R239*	FUT8_uc001xio.2_Nonsense_Mutation_p.R239*|FUT8_uc010tsp.1_Nonsense_Mutation_p.R76*|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Nonsense_Mutation_p.R239*|FUT8_uc001xiq.2_Nonsense_Mutation_p.R110*|FUT8_uc001xis.2_5'Flank	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	239	Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TGGCACCCAGCGAACACTCAT	0.473													21	68					0	0	0	0	T	66136078	T	T	66136078	4	4	244	1	0	0	0	0	0	1	0	0	6144	760	27	1	832	1	FUT8	14	66136078	Nonsense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	14898958	66136078	41213462	97	44893											
C14orf68	283600	broad.mit.edu	37	chr14	100793680	100793680	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaaggccgacatcacgctCtcgggatgcgcctccggcct	7	6	11	17	5	2	0	1	0	1	0	4	2	3	1	5	3	1	1	5	3	1	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr14:100793680C>G	uc001yhc.2	+	4	373	c.300C>G	c.(298-300)CTC>CTG	p.L100L	C14orf68_uc001yhd.2_5'UTR	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	100	Solcar 2.|Helical; Name=3; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				ACATCACGCTCTCGGGATGCG	0.662													16	60					0	0	0	0	G	100793680	G	G	100793680	2	3	244	1	0	0	0	0	0	0	0	1	1784	900	32	2		2	C14orf68	14	100793680	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	34657602	100793680	6555860	98	44894											
ACTC1	70	broad.mit.edu	37	chr15	35086901	35086901	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgccgcgggcggcccaCgatggacgggaagacagcgc	7	3	18	13	6	0	1	0	0	0	1	0	4	0	3	2	5	2	0	2	5	1	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr15:35086901C>T	uc001ziu.1	-	2	352	c.109G>A	c.(109-111)GTG>ATG	p.V37M	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	37					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GGGCGGCCCACGATGGACGGG	0.687													9	25					0	0	0	0	T	35086901	T	T	35086901	3	4	244	1	0	0	0	0	1	0	0	0	195	536	19	1	1048	1	ACTC1	15	35086901	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08		35086901	67444491	99	44895											
WDR72	256764	broad.mit.edu	37	chr15	53907901	53907901	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgagaaattatcttcattCaaagaaattcccaaagaaat	19	11	5	6	0	3	3	2	1	1	3	4	4	4	3	1	0	0	0	1	0	6	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr15:53907901C>G	uc002acj.2	-	15	2544	c.2502G>C	c.(2500-2502)TTG>TTC	p.L834F	WDR72_uc010bfi.1_Missense_Mutation_p.L834F	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	834										lung(1)|skin(1)	2				all cancers(107;0.0511)		TATCTTCATTCAAAGAAATTC	0.343													9	75					0	0	0	0	G	53907901	G	G	53907901	3	3	244	1	0	0	0	0	1	0	0	0	17390	825	29	2	830	2	WDR72	15	53907901	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	18821000	53907901	48623491	100	44896											
ADAM10	102	broad.mit.edu	37	chr15	58933155	58933155	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttctcatcagcagttgtaTtgatctaaaatccaaaacaa	15	12	4	10	0	3	1	2	1	2	0	5	1	4	1	2	0	2	3	2	0	6	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr15:58933155T>C	uc002afd.1	-	8	1277	c.833A>G	c.(832-834)AAT>AGT	p.N278S	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Intron|ADAM10_uc002afe.1_Intron	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	278	Peptidase M12B.|Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		AGCAGTTGTATTGATCTAAAA	0.373													3	38					0	0	0	0	C	58933155	C	C	58933155	3	2	244	1	0	0	0	0	1	0	0	0	234	1493	52	5	1449	5	ADAM10	15	58933155	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08	5025254	58933155	43598237	101	44897											
ADAM10	102	broad.mit.edu	37	chr15	58971446	58971446	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatccttcaaatcttccatCaataacagacccatggctaa	15	10	4	12	0	3	1	2	0	1	1	5	2	5	1	3	1	1	1	3	1	5	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr15:58971446C>G	uc002afd.1	-	4	805	c.361G>C	c.(361-363)GAT>CAT	p.D121H	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Intron|ADAM10_uc002afe.1_Intron|ADAM10_uc002afg.2_Missense_Mutation_p.D121H	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	121	Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		AATCTTCCATCAATAACAGAC	0.358													4	42					0	0	0	0	G	58971446	G	G	58971446	3	3	244	1	0	0	0	0	1	0	0	0	234	826	29	2	1937	2	ADAM10	15	58971446	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	38291	58971446	43559946	102	44898											
FOXB1	27023	broad.mit.edu	37	chr15	60297874	60297874	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctccatggcgagtggcgacTacagcgcctacggcgtgccg	6	7	14	14	6	1	0	0	0	1	0	2	2	1	0	3	3	4	0	3	3	2	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr15:60297874T>C	uc002agj.1	+	2	1191	c.712T>C	c.(712-714)TAC>CAC	p.Y238H	FOXB1_uc010bgh.1_Intron	NM_012182	NP_036314	Q99853	FOXB1_HUMAN	forkhead box B1	238					axon target recognition|cell migration in diencephalon|epithelial cell differentiation involved in mammary gland alveolus development|floor plate development|hypothalamus cell migration|inferior colliculus development|lactation|mammillothalamic axonal tract development|negative regulation of neuron apoptosis|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|telencephalon cell migration|visual learning	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|central_nervous_system(1)	2						GAGTGGCGACTACAGCGCCTA	0.706													9	11					0	0	0	0	C	60297874	C	C	60297874	3	2	244	1	0	0	0	0	1	0	0	0	6024	1522	53	5	714	5	FOXB1	15	60297874	Missense_Mutation	SNP	T	TCGA-CV-7261-01A-11D-2012-08	1326428	60297874	42233518	103	44899											
IQCH	64799	broad.mit.edu	37	chr15	67687836	67687836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtaccaaatctggaggcaaaCgtgtctttgacagtgccaat	12	10	10	9	1	2	1	0	1	2	0	2	2	2	2	2	2	3	2	2	2	4	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr15:67687836C>T	uc002aqo.1	+	13	1887	c.1840C>T	c.(1840-1842)CGT>TGT	p.R614C	IQCH_uc002aqq.1_Intron|IQCH_uc002aqp.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	614										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		TGGAGGCAAACGTGTCTTTGA	0.448													9	68					0	0	0	0	T	67687836	T	T	67687836	3	4	244	1	0	0	0	0	1	0	0	0	7850	536	19	1	2018	1	IQCH	15	67687836	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	7389962	67687836	34843556	104	44900											
RGS11	8786	broad.mit.edu	37	chr16	319529	319529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatctccagcgggatcccaGcctctgccaggagggccttg	6	8	12	15	1	3	0	1	0	2	0	5	2	4	2	5	3	3	0	5	3	0	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr16:319529G>A	uc002cgj.1	-	16	1265	c.1262C>T	c.(1261-1263)GCT>GTT	p.A421V	ITFG3_uc010uud.1_RNA|RGS11_uc002cgi.1_Missense_Mutation_p.A400V|RGS11_uc010bqs.1_Missense_Mutation_p.A410V|RGS11_uc002cgk.1_Missense_Mutation_p.A237V	NM_183337	NP_899180	O94810	RGS11_HUMAN	regulator of G-protein signalling 11 isoform 1	421					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			lung(1)|pancreas(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CGGGATCCCAGCCTCTGCCAG	0.652													16	15					0	0	0	0	A	319529	A	A	319529	3	1	244	1	0	0	0	0	1	0	0	0	13359	971	34	4	149	4	RGS11	16	319529	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08		319529	90035224	105	44901											
IFT140	9742	broad.mit.edu	37	chr16	1561083	1561083	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcacggcgtccacggcctgCgggctcacgtagtaggacat	7	7	14	13	5	1	0	1	0	0	0	2	1	2	1	2	4	2	4	2	4	2	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr16:1561083C>T	uc002cmb.2	-	31	4613	c.4251G>A	c.(4249-4251)CCG>CCA	p.P1417P	IFT140_uc002clz.2_Silent_p.P1030P	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	1417										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				CCACGGCCTGCGGGCTCACGT	0.662													6	8					0	0	0	0	T	1561083	T	T	1561083	2	4	244	1	0	0	0	0	0	0	0	1	7595	755	27	1		1	IFT140	16	1561083	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	1241554	1561083	88793670	106	44902											
CIITA	4261	broad.mit.edu	37	chr16	10995979	10995979	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccctgcctgccactgcctgCgctgttcaaccaggagccag	6	7	11	17	1	1	0	1	0	0	0	1	1	1	1	6	1	6	2	6	1	1	1	rs149076617		TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr16:10995979C>T	uc002dai.3	+	7	699	c.566C>T	c.(565-567)GCG>GTG	p.A189V	CIITA_uc002daj.3_Missense_Mutation_p.A190V|CIITA_uc002dak.3_Intron|CIITA_uc002dag.2_Missense_Mutation_p.A189V|CIITA_uc002dah.2_Intron|CIITA_uc010bup.1_Missense_Mutation_p.A189V	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	189					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CCACTGCCTGCGCTGTTCAAC	0.622			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								8	78					0	0	0	0	T	10995979	T	T	10995979	3	4	244	1	0	0	0	0	1	0	0	0	3443	768	27	1	592	1	CIITA	16	10995979	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	9434896	10995979	79358774	107	44903											
KIAA0430	9665	broad.mit.edu	37	chr16	15715663	15715663	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttttgctgccaattttgtAtctgtggaggctattcactg	6	18	9	8	0	2	0	1	0	1	0	2	1	2	1	1	2	2	3	1	2	3	7			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr16:15715663A>G	uc002ddr.2	-	12	2759	c.2566T>C	c.(2566-2568)TAC>CAC	p.Y856H	KIAA0430_uc002ddq.2_Missense_Mutation_p.Y690H|KIAA0430_uc010uzv.1_Missense_Mutation_p.Y852H|KIAA0430_uc010uzw.1_Missense_Mutation_p.Y855H	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	855	RRM.					peroxisome	nucleotide binding|RNA binding				0						CCAATTTTGTATCTGTGGAGG	0.458													25	40					0	0	0	0	G	15715663	G	G	15715663	3	3	244	1	0	0	0	0	1	0	0	0	8216	449	16	5	2726	5	KIAA0430	16	15715663	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08	4719684	15715663	74639090	108	44904											
CDH11	1009	broad.mit.edu	37	chr16	65026844	65026844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgcttccaccgaaaaatagGgttgtccttcgaggatactg	10	11	11	9	2	0	0	0	0	0	0	3	3	2	1	3	2	2	2	3	2	4	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr16:65026844G>A	uc002eoi.2	-	5	1051	c.617C>T	c.(616-618)CCC>CTC	p.P206L	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Missense_Mutation_p.P206L|CDH11_uc010vin.1_Missense_Mutation_p.P80L	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	206	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CGAAAAATAGGGTTGTCCTTC	0.438			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			5	52					0	0	0	0	A	65026844	A	A	65026844	3	1	244	1	0	0	0	0	1	0	0	0	3112	1232	43	4	1809	4	CDH11	16	65026844	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	49311181	65026844	25327909	109	44905											
SDR42E1	93517	broad.mit.edu	37	chr16	82032990	82032990	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggctggaagttgtagagtCgacccaaaatgaagtgaacc	14	7	13	7	1	0	3	0	2	0	1	1	5	0	4	2	2	1	3	2	2	6	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr16:82032990C>A	uc002fgu.2	-	3	1036	c.908G>T	c.(907-909)CGA>CTA	p.R303L		NM_145168	NP_660151	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E,	303					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding				0						GTTGTAGAGTCGACCCAAAAT	0.463													23	21					4.4004e-07	3.19326e-06	1	0	A	82032990	A	A	82032990	3	1	244	1	0	0	0	0	1	0	0	0	14038	884	31	3	277	3	SDR42E1	16	82032990	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	17006146	82032990	8321763	110	44906											
CAMTA2	23125	broad.mit.edu	37	chr17	4883671	4883671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcctcttgaagaaccccCtcgagaagtgggagggctag	9	7	13	12	1	1	3	0	1	1	2	3	5	2	4	4	2	1	1	4	2	4	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr17:4883671C>T	uc002gah.1	-	9	1054	c.946G>A	c.(946-948)GGG>AGG	p.G316R	CAMTA2_uc010cku.1_Missense_Mutation_p.G339R|CAMTA2_uc002gag.1_Missense_Mutation_p.G315R|CAMTA2_uc002gai.1_Missense_Mutation_p.G318R|CAMTA2_uc010ckv.1_5'UTR|CAMTA2_uc010vsu.1_Missense_Mutation_p.G129R	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	316					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GAAGAACCCCCTCGAGAAGTG	0.592											OREG0024111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	15					0	0	0	0	T	4883671	T	T	4883671	3	4	244	1	0	0	0	0	1	0	0	0	2626	681	24	4	2772	4	CAMTA2	17	4883671	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08		4883671	76311539	111	44907											
JUP	3728	broad.mit.edu	37	chr17	39927914	39927914	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgaccttggctggggggcaCcccctgggtgtaagtggtgg	4	9	18	10	0	0	1	0	1	0	0	0	1	0	1	3	7	0	3	3	7	1	2			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr17:39927914C>G	uc002hxq.2	-	2	470	c.193G>C	c.(193-195)GTG>CTG	p.V65L	JUP_uc010wfs.1_Missense_Mutation_p.V65L|JUP_uc002hxr.2_Missense_Mutation_p.V65L|JUP_uc002hxs.2_Missense_Mutation_p.V65L	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	65					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		CTGGGGGGCACCCCCTGGGTG	0.612													17	37					0	0	0	0	G	39927914	G	G	39927914	3	3	244	1	0	0	0	0	1	0	0	0	8011	507	18	4	2096	4	JUP	17	39927914	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	35044243	39927914	41267296	112	44908											
KIAA1267	284058	broad.mit.edu	37	chr17	44110827	44110827	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaagatcaacctcccgccagCtgcaaaaccaagaacagaca	17	3	7	14	1	1	3	1	0	0	3	2	4	2	3	4	0	5	2	4	0	6	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr17:44110827C>T	uc002ikb.2	-	11	2752	c.2667_splice	c.e11-1	p.S889_splice	KIAA1267_uc002ikc.2_Splice_Site_p.S889_splice|KIAA1267_uc002ikd.2_Splice_Site_p.S889_splice|KIAA1267_uc010dav.2_Splice_Site_p.S888_splice|KIAA1267_uc010wkb.1_Splice_Site_p.S220_splice|KIAA1267_uc010wkc.1_Splice_Site_p.S157_splice	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058							MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				CTCCCGCCAGCTGCAAAACCA	0.502													11	24					0	0	0	0	T	44110827	T	T	44110827	5	4	244	1	0	0	0	0	0	0	1	0	8258	811	28	4	667	4	KIAA1267	17	44110827	Splice_Site	SNP	C	TCGA-CV-7261-01A-11D-2012-08	4182913	44110827	37084383	113	44909											
P4HB	5034	broad.mit.edu	37	chr17	79804356	79804356	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactctgtgatcctctctgcCgtcagctcctccgattcggg	5	12	9	15	3	3	1	1	1	2	0	8	2	6	1	4	1	3	1	4	1	1	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr17:79804356C>T	uc002kbn.1	-	7	1202	c.1005G>A	c.(1003-1005)ACG>ACA	p.T335T	P4HB_uc002kbl.1_Silent_p.T12T|P4HB_uc002kbm.1_Silent_p.T12T	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	335					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			TCCTCTCTGCCGTCAGCTCCT	0.632													36	98					0	0	0	0	T	79804356	T	T	79804356	2	4	244	1	0	0	0	0	0	0	0	1	11413	639	23	1		1	P4HB	17	79804356	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	35693529	79804356	1390854	114	44910											
SLC14A2	8170	broad.mit.edu	37	chr18	43249308	43249308	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgggtaccatcttcagcAagtgggacctcccagtcttc	7	10	9	15	0	3	0	1	0	2	0	5	1	4	1	4	2	2	2	4	2	2	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr18:43249308A>C	uc010dnj.2	+	17	2395	c.2074A>C	c.(2074-2076)AAG>CAG	p.K692Q	SLC14A2_uc002lbe.2_Missense_Mutation_p.K692Q	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	692						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CATCTTCAGCAAGTGGGACCT	0.552													8	132					0	0	0	0	C	43249308	C	C	43249308	3	2	244	1	0	0	0	0	1	0	0	0	14462	131	5	5	2132	5	SLC14A2	18	43249308	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08		43249308	34827940	115	44911											
GPX4	2879	broad.mit.edu	37	chr19	1105714	1105714	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgggctacaacgtcaaattcGatatgttcagcaagatctgc	12	10	9	10	3	3	1	2	0	1	1	4	2	3	1	0	1	4	3	0	1	5	4			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:1105714G>C	uc010xgg.1	+	5	489	c.382G>C	c.(382-384)GAT>CAT	p.D128H	GPX4_uc010xgh.1_Missense_Mutation_p.D128H|GPX4_uc010xgi.1_Missense_Mutation_p.D165H	NM_002085	NP_002076	P36969	GPX4_HUMAN	glutathione peroxidase 4 isoform A precursor	128					multicellular organismal development|phospholipid metabolic process		glutathione peroxidase activity|phospholipid-hydroperoxide glutathione peroxidase activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glutathione(DB00143)	CGTCAAATTCGATATGTTCAG	0.587													5	13					0	0	0	0	C	1105714	C	C	1105714	3	2	244	1	0	0	0	0	1	0	0	0	6781	1058	37	3	595	3	GPX4	19	1105714	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08		1105714	58023269	116	44912											
ZFR2	23217	broad.mit.edu	37	chr19	3871979	3871980	+	5'Flank	INS	-	A	A																															ggaatagagtgaggctctccINSaaaaaaaaaagaagaagaag																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	01f28aef-6802-4d54-a644-448887298280	g.chr19:3871979_3871980insA	uc002lyw.2	-						ZFR2_uc010xhx.1_5'Flank|ZFR2_uc002lyx.3_5'Flank|ZFR2_uc010xhy.1_5'Flank	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1							intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		tgaggctctccaaaaaaaaaag	0.267													---	---	---								A	3871980	A	A	3871979	6	5	244	0	1	1	1	0	0	0	0	0	17727	609	21	0		0	ZFR2	19	3871979	5'Flank	INS	-	TCGA-CV-7261-01A-11D-2012-08	2766265	3871979	55257004	117	44913											
MUC16	94025	broad.mit.edu	37	chr19	9045870	9045870	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttacagatggtgaggtttCtgtgttccaggaggtcacag	9	12	14	6	0	2	2	1	1	1	1	3	3	3	3	1	4	1	3	1	4	1	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:9045870C>A	uc002mkp.2	-	5	35965	c.35761G>T	c.(35761-35763)GAA>TAA	p.E11921*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11923	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGAGGTTTCTGTGTTCCAG	0.498													50	92					1.07234e-20	8.34563e-20	1	0	A	9045870	A	A	9045870	4	1	244	1	0	0	0	0	0	1	0	0	10026	922	32	2	8082	2	MUC16	19	9045870	Nonsense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	5173891	9045870	50083113	118	44914											
ZNF20	7568	broad.mit.edu	37	chr19	12244792	12244792	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactttcacagagtttctctCtcataagacttcagtgaaaa	13	14	5	9	0	4	3	3	1	2	2	6	3	4	3	0	0	1	1	0	0	4	5			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:12244792C>T	uc002mtf.1	-	4	352	c.209G>A	c.(208-210)AGA>AAA	p.R70K	ZNF20_uc002mte.1_Missense_Mutation_p.R35K|ZNF20_uc002mtg.1_Missense_Mutation_p.R70K	NM_021143	NP_066966	P17024	ZNF20_HUMAN	zinc finger protein 20	70	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGTTTCTCTCTCATAAGACT	0.299													19	54					0	0	0	0	T	12244792	T	T	12244792	3	4	244	1	0	0	0	0	1	0	0	0	17828	913	32	2	1393	2	ZNF20	19	12244792	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	3198922	12244792	46884191	119	44915											
CACNA1A	773	broad.mit.edu	37	chr19	13345741	13345741	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccccttctcaccggaagAgaagcatgagggcctggaag	10	6	14	11	1	1	2	1	1	1	1	3	5	2	4	4	4	1	1	4	4	3	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:13345741A>G	uc010dze.2	-	34	5482	c.5246T>C	c.(5245-5247)CTC>CCC	p.L1749P	CACNA1A_uc010xnd.1_Missense_Mutation_p.L454P|CACNA1A_uc002mwx.3_Missense_Mutation_p.L454P|CACNA1A_uc010dzc.2_Missense_Mutation_p.L1274P|CACNA1A_uc002mwy.3_Missense_Mutation_p.L1748P|CACNA1A_uc002mwv.3_Missense_Mutation_p.L265P	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1749	Extracellular (Potential).|IV.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCACCGGAAGAGAAGCATGAG	0.522											OREG0025293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	80					0	0	0	0	G	13345741	G	G	13345741	3	3	244	1	0	0	0	0	1	0	0	0	2550	304	11	5	2434	5	CACNA1A	19	13345741	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08	1100949	13345741	45783242	120	44916											
CACNA1A	773	broad.mit.edu	37	chr19	13414674	13414674	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatcccgtcgtacatgacctCgttccagtcttcgcccgtca	6	11	8	16	5	2	1	1	1	1	0	7	2	4	1	4	0	1	2	4	0	1	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:13414674C>T	uc010dze.2	-	16	2250	c.2014G>A	c.(2014-2016)GAG>AAG	p.E672K	CACNA1A_uc010dzc.2_Missense_Mutation_p.E197K|CACNA1A_uc002mwy.3_Missense_Mutation_p.E671K|CACNA1A_uc010xne.1_Missense_Mutation_p.E197K	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	672	Extracellular (Potential).|II.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TACATGACCTCGTTCCAGTCT	0.577													14	143					0	0	0	0	T	13414674	T	T	13414674	3	4	244	1	0	0	0	0	1	0	0	0	2550	893	31	1	5748	1	CACNA1A	19	13414674	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	68933	13414674	45714309	121	44917											
BRD4	23476	broad.mit.edu	37	chr19	15366308	15366308	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgtccaagctgagctgcCgcttctcctcataggacata	9	11	9	12	1	2	2	1	2	1	0	4	3	3	3	3	1	3	3	3	1	3	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:15366308C>T	uc002nar.2	-	10	2069	c.1847G>A	c.(1846-1848)CGG>CAG	p.R616Q	BRD4_uc002nas.2_Missense_Mutation_p.R616Q|BRD4_uc002nat.3_Missense_Mutation_p.R616Q	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	616					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GCTGAGCTGCCGCTTCTCCTC	0.597			T	NUT|C15orf55	lethal midline carcinoma of young people								26	95					0	0	0	0	T	15366308	T	T	15366308	3	4	244	1	0	0	0	0	1	0	0	0	1509	652	23	1	2300	1	BRD4	19	15366308	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	1951634	15366308	43762675	122	44918											
NWD1	284434	broad.mit.edu	37	chr19	16860942	16860942	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggaggtgaagcccctttccGgaaaccaaggccagcagatg	11	5	14	11	1	0	2	0	1	0	1	1	4	1	4	5	4	3	1	5	4	3	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:16860942G>A	uc002neu.3	+	6	1911	c.1489G>A	c.(1489-1491)GGA>AGA	p.G497R	NWD1_uc002net.3_Missense_Mutation_p.G362R|NWD1_uc002nev.3_Missense_Mutation_p.G291R			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	497	NACHT.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						GCCCCTTTCCGGAAACCAAGG	0.632													6	93					0	0	0	0	A	16860942	A	A	16860942	3	1	244	1	0	0	0	0	1	0	0	0	10835	1117	39	1	1090	1	NWD1	19	16860942	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	1494634	16860942	42268041	123	44919											
GMIP	51291	broad.mit.edu	37	chr19	19749068	19749068	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctcaggggacccctgggagCgtgcccgcaggtcctcgctg	4	6	15	16	3	1	0	1	0	0	0	3	2	2	2	5	4	2	2	5	4	0	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:19749068C>T	uc002nnd.2	-	9	806	c.689G>A	c.(688-690)CGC>CAC	p.R230H	GMIP_uc010xrb.1_Missense_Mutation_p.R230H|GMIP_uc010xrc.1_Missense_Mutation_p.R230H	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	230					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						CCCCTGGGAGCGTGCCCGCAG	0.716													13	16					0	0	0	0	T	19749068	T	T	19749068	3	4	244	1	0	0	0	0	1	0	0	0	6528	768	27	1	2275	1	GMIP	19	19749068	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	2888126	19749068	39379915	124	44920											
ZNF14	7561	broad.mit.edu	37	chr19	19822424	19822424	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttacattgatacggtttctCtccagtgtgagtcctttcat	7	18	7	9	1	2	2	1	2	1	0	5	2	4	2	2	1	2	1	2	1	2	6			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:19822424C>T	uc002nnk.1	-	4	1820	c.1666G>A	c.(1666-1668)GAG>AAG	p.E556K		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	556					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				TACGGTTTCTCTCCAGTGTGA	0.408													5	105					0	0	0	0	T	19822424	T	T	19822424	3	4	244	1	0	0	0	0	1	0	0	0	17795	922	32	2	266	2	ZNF14	19	19822424	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	73356	19822424	39306559	125	44921											
RYR1	6261	broad.mit.edu	37	chr19	39019040	39019040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcctgtttccgtatgacgcCcctgtacaacctgcccacgt	6	10	9	16	3	0	1	0	1	0	0	1	1	1	1	6	1	3	3	6	1	3	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:39019040C>T	uc002oit.2	+	74	11049	c.10919C>T	c.(10918-10920)CCC>CTC	p.P3640L	RYR1_uc002oiu.2_Missense_Mutation_p.P3635L|RYR1_uc002oiv.1_Missense_Mutation_p.P555L|RYR1_uc010xuf.1_Missense_Mutation_p.P560L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3640					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGTATGACGCCCCTGTACAAC	0.612													7	60					0	0	0	0	T	39019040	T	T	39019040	3	4	244	1	0	0	0	0	1	0	0	0	13833	623	22	4	11213	4	RYR1	19	39019040	Missense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08	19196616	39019040	20109943	126	44922											
ADCK4	79934	broad.mit.edu	37	chr19	41209448	41209448	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgggtgggcgcctcacccGcgggcagggccgcgctcatc	4	5	17	15	5	2	0	2	0	0	0	3	0	2	0	3	4	0	2	3	4	0	0			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:41209448G>A	uc002oor.2	-	9	1099	c.797C>T	c.(796-798)GCG>GTG	p.A266V	ADCK4_uc002oop.1_5'Flank|ADCK4_uc002ooq.1_Missense_Mutation_p.A225V	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	266	Protein kinase.					integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			CGCCTCACCCGCGGGCAGGGC	0.647													11	5					0	0	0	0	A	41209448	A	A	41209448	3	1	244	1	0	0	0	0	1	0	0	0	290	1087	38	1	865	1	ADCK4	19	41209448	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	2190408	41209448	17919535	127	44923											
ZNF473	25888	broad.mit.edu	37	chr19	50549349	50549350	+	Missense_Mutation	DNP	TC	AG	AG																															attttttgtgagtgggaagaTcttggatcagaacccagaac																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr19:50549349_50549350TC>AG	uc002prn.2	+	5	1886_1887	c.1649_1650TC>AG	c.(1648-1650)ATC>AAG	p.I550K	ZNF473_uc002prm.2_Missense_Mutation_p.I550K|ZNF473_uc010ybo.1_Missense_Mutation_p.I538K	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	550	Interaction with SLBP/pre-mRNA complex.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		AGTGGGAAGATCTTGGATCAGA	0.455													5	32					0	0	0	0	AG	50549350	AG	AG	50549349	3	1	244	1	0	0	0	0	1	0	0	0	17998	1435	50	5	1663	5	ZNF473	19	50549349	Missense_Mutation	DNP	TC	TCGA-CV-7261-01A-11D-2012-08	9339901	50549349	8579634	128	44924											
PAK7	57144	broad.mit.edu	37	chr20	9546783	9546783	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaggagccccagctgggCggcgggtaggtgctggatga	7	5	21	8	2	0	1	0	1	0	0	0	5	0	4	2	7	3	3	2	7	1	1	rs140739060	byFrequency	TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr20:9546783C>T	uc002wnl.2	-	6	1784	c.1239G>A	c.(1237-1239)CCG>CCA	p.P413P	PAK7_uc002wnk.2_Silent_p.P413P|PAK7_uc002wnj.2_Silent_p.P413P|PAK7_uc010gby.1_Silent_p.P413P	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	413	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity	p.P413L(1)		lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			CCCAGCTGGGCGGCGGGTAGG	0.657													20	48					0	0	0	0	T	9546783	T	T	9546783	2	4	244	1	0	0	0	0	0	0	0	1	11459	755	27	1		1	PAK7	20	9546783	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08		9546783	53478737	129	44925											
MACROD2	140733	broad.mit.edu	37	chr20	15843468	15843468	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaatgaatgagtttttctccGtaggtgagtaaagcaacttc	13	13	9	6	1	1	3	0	3	1	0	3	3	1	3	1	1	2	4	1	1	6	5	rs143525826	by1000genomes	TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr20:15843468G>A	uc002wou.2	+	9	988	c.724G>A	c.(724-726)GTA>ATA	p.V242I	MACROD2_uc002wot.2_Missense_Mutation_p.V242I|MACROD2_uc002woz.2_Missense_Mutation_p.V7I|MACROD2_uc002wpb.2_Missense_Mutation_p.V7I	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1	242											0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				GTTTTTCTCCGTAGGTGAGTA	0.363													8	33					0	0	0	0	A	15843468	A	A	15843468	3	1	244	1	0	0	0	0	1	0	0	0	9197	1145	40	1	758	1	MACROD2	20	15843468	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	6296685	15843468	47182052	130	44926											
PRPF6	24148	broad.mit.edu	37	chr20	62657405	62657405	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcggagcagtgcccccacCgcccgggtacgcagtggcag	6	3	16	16	5	0	0	0	0	0	0	0	1	0	1	4	3	3	4	4	3	1	1	rs151209735		TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr20:62657405C>T	uc002yho.2	+	15	2190	c.2022C>T	c.(2020-2022)ACC>ACT	p.T674T	PRPF6_uc002yhp.2_Intron	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	674					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GTGCCCCCACCGCCCGGGTAC	0.682													8	51					0	0	0	0	T	62657405	T	T	62657405	2	4	244	1	0	0	0	0	0	0	0	1	12636	639	23	1		1	PRPF6	20	62657405	Silent	SNP	C	TCGA-CV-7261-01A-11D-2012-08	46813937	62657405	368115	131	44927											
TPTE	7179	broad.mit.edu	37	chr21	10952943	10952943	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatgatacaattgaatgcAcaattttcttaatcttgctg	13	15	7	6	0	2	2	0	2	2	0	2	3	2	3	0	1	3	2	0	1	5	6			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr21:10952943A>C	uc002yip.1	-	9	622	c.254T>G	c.(253-255)GTG>GGG	p.V85G	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.V67G|TPTE_uc002yir.1_Missense_Mutation_p.V47G|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	85					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATTGAATGCACAATTTTCTT	0.249													10	39					0	0	0	0	C	10952943	C	C	10952943	3	2	244	1	0	0	0	0	1	0	0	0	16497	159	6	5	1465	5	TPTE	21	10952943	Missense_Mutation	SNP	A	TCGA-CV-7261-01A-11D-2012-08		10952943	37176952	132	44928											
MAPK1	5594	broad.mit.edu	37	chr22	22127164	22127164	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaacatgagctcttacctCgtcactcgggtcgtaatact	10	11	9	11	3	2	1	1	1	1	0	5	2	2	2	1	2	4	2	1	2	4	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chr22:22127164C>A	uc002zvn.2	-	7	1204	c.964G>T	c.(964-966)GAG>TAG	p.E322*	MAPK1_uc002zvo.2_Nonsense_Mutation_p.E322*|MAPK1_uc010gtk.1_Nonsense_Mutation_p.E278*	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	322					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	GCTCTTACCTCGTCACTCGGG	0.478													33	55					1.22384e-17	9.32198e-17	1	0	A	22127164	A	A	22127164	4	1	244	1	0	0	0	0	0	1	0	0	9324	893	31	3	126	3	MAPK1	22	22127164	Nonsense_Mutation	SNP	C	TCGA-CV-7261-01A-11D-2012-08		22127164	29177402	133	44929											
DLG3	1741	broad.mit.edu	37	chrX	69673592	69673592	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctccttcatcctggcaggAggcccagctgacctgagtgg	6	9	13	13	0	2	2	1	2	1	0	4	3	3	3	4	4	1	2	4	4	0	1			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chrX:69673592A>G	uc004dyi.1	+	8	1579	c.1251A>G	c.(1249-1251)GGA>GGG	p.G417G	DLG3_uc004dyj.1_Silent_p.G80G|DLG3_uc011mpn.1_5'Flank	NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	417	PDZ 3.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)					TCCTGGCAGGAGGCCCAGCTG	0.567													2	6					0	0	0	0	G	69673592	G	G	69673592	2	3	244	1	0	0	0	0	0	0	0	1	4578	291	11	5		5	DLG3	23	69673592	Silent	SNP	A	TCGA-CV-7261-01A-11D-2012-08		69673592	85596968	134	44930											
BTK	695	broad.mit.edu	37	chrX	100617676	100617676	+	Silent	SNP	T	A	A																															agatcactgttgtaccggatTactgtagcaggaaagaagag																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chrX:100617676T>A	uc004ehg.2	-	6	586	c.393A>T	c.(391-393)GTA>GTT	p.V131V	BTK_uc010nnn.2_Silent_p.V131V|BTK_uc010nno.2_Silent_p.V165V|BTK_uc004ehi.2_Silent_p.V131V	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	131	PH.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TGTACCGGATTACTGTAGCAG	0.458									Agammaglobulinemia_X-linked				6	95					0	0	0	0	A	100617676	A	A	100617676	2	1	244	1	0	0	0	0	0	0	0	1	1562	1768	61	5		5	BTK	23	100617676	Silent	SNP	T	TCGA-CV-7261-01A-11D-2012-08	30944084	100617676	54652884	135	44931	95	2									
BTK	695	broad.mit.edu	37	chrX	100617678	100617678	+	Splice_Site	SNP	C	A	A																															atcactgttgtaccggattaCtgtagcaggaaagaagagag																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chrX:100617678C>A	uc004ehg.2	-	6	585	c.392_splice	c.e6-1	p.V131_splice	BTK_uc010nnn.2_Splice_Site_p.V131_splice|BTK_uc010nno.2_Splice_Site_p.V165_splice|BTK_uc004ehi.2_Splice_Site_p.V131_splice	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase						calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TACCGGATTACTGTAGCAGGA	0.463									Agammaglobulinemia_X-linked				6	92					0.00116845	0.00789252	1	0	A	100617678	A	A	100617678	5	1	244	1	0	0	0	0	0	0	1	0	1562	579	20	4	1644	4	BTK	23	100617678	Splice_Site	SNP	C	TCGA-CV-7261-01A-11D-2012-08	2	100617678	54652882	136	44932	95	2									
TCEAL3	85012	broad.mit.edu	37	chrX	102864401	102864403	+	In_Frame_Del	DEL	GAG	-	-																															aggaaaggcatctgagcagtGaggagatgatgagagaatgt																										TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chrX:102864401_102864403delGAG	uc004ekq.2	+	3	671_673	c.409_411delGAG	c.(409-411)GAGdel	p.E138del	TCEAL3_uc004ekr.2_In_Frame_Del_p.E138del	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						TCTGAGCAGTGAGGAGATGATGA	0.478													---	---	---								-	102864403	-	-	102864401	7	5	244	1	0	1	0	1	0	0	0	0	15738	1291	45	0	411	0	TCEAL3	23	102864401	In_Frame_Del	DEL	GAG	TCGA-CV-7261-01A-11D-2012-08	2246723	102864401	52406159	137	44933											
AGTR2	186	broad.mit.edu	37	chrX	115304382	115304382	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttcctggatgctctggcctgGatgggtgtcattaatagctg	6	14	13	8	0	2	0	1	0	1	0	3	2	3	2	2	4	2	2	2	4	2	3			TCGA-CV-7261-01A-11D-2012-08	TCGA-CV-7261-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa7bc79-d05b-41da-8bcc-8d5ad4451b0c	b34ad9ae-e439-49c1-9512-daedfc15ed13	g.chrX:115304382G>C	uc004eqh.3	+	3	1056	c.849G>C	c.(847-849)TGG>TGC	p.W283C		NM_000686	NP_000677	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	283	Extracellular (Potential).				behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3						CTCTGGCCTGGATGGGTGTCA	0.507													11	84					0	0	0	0	C	115304382	C	C	115304382	3	2	244	1	0	0	0	0	1	0	0	0	402	1183	41	2	851	2	AGTR2	23	115304382	Missense_Mutation	SNP	G	TCGA-CV-7261-01A-11D-2012-08	12439981	115304382	39966178	138	44934											
MTHFR	4524	broad.mit.edu	37	chr1	11854027	11854027	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggtcggaggacggcttcccGttgatgttgggctgtgagtt	4	12	18	7	3	0	2	0	2	0	0	2	4	1	4	1	5	0	5	1	5	0	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:11854027G>A	uc001atc.1	-	9	1651	c.1467C>T	c.(1465-1467)AAC>AAT	p.N489N	MTHFR_uc001atb.1_Silent_p.N512N	NM_005957	NP_005948	P42898	MTHR_HUMAN	5,10-methylenetetrahydrofolate reductase	489					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	ACGGCTTCCCGTTGATGTTGG	0.657													35	73					0	0	0	0	A	11854027	A	A	11854027	2	1	245	1	0	0	0	0	0	0	0	1	9984	1136	40	1		1	MTHFR	1	11854027	Silent	SNP	G	TCGA-CV-7263-01A-11D-2012-08		11854027	237396594	1	44935											
C1orf113	79729	broad.mit.edu	37	chr1	36785374	36785374	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcccccagctccagagaaCgcccccagctccaagaagat	12	3	9	17	1	0	3	0	0	0	3	2	4	2	3	6	1	3	2	6	1	3	0			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:36785374C>T	uc010oia.1	+	14	1138	c.1110C>T	c.(1108-1110)AAC>AAT	p.N370N	C1orf113_uc010oib.1_Silent_p.N259N|C1orf113_uc010oic.1_RNA|C1orf113_uc009vuz.1_Silent_p.N16N	NM_001162530	NP_001156002	A4FU49	SH321_HUMAN	SH3 domain-containing protein C1orf113 isoform	254											0		Myeloproliferative disorder(586;0.0393)				CTCCAGAGAACGCCCCCAGCT	0.622													12	23					0	0	0	0	T	36785374	T	T	36785374	2	4	245	1	0	0	0	0	0	0	0	1	1995	535	19	1		1	C1orf113	1	36785374	Silent	SNP	C	TCGA-CV-7263-01A-11D-2012-08	24931347	36785374	212465247	2	44936											
GPBP1L1	60313	broad.mit.edu	37	chr1	46096158	46096159	+	Missense_Mutation	DNP	GC	AA	AA																															tgtcctcctcacttacctgtGctctgcttctagagagtgtg																										TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:46096158_46096159GC>AA	uc001coq.2	-	11	2525_2526	c.1164_1165GC>TT	c.(1162-1167)GAGCAC>GATTAC	p.388_389EH>DY	GPBP1L1_uc001coo.2_Missense_Mutation_p.132_133EH>DY	NM_021639	NP_067652	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	388_389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACTTACCTGTGCTCTGCTTCTA	0.49													18	69					0	0	0	0	AA	46096159	AA	AA	46096158	3	1	245	1	0	0	0	0	1	0	0	0	6634	1319	46	4	271	4	GPBP1L1	1	46096158	Missense_Mutation	DNP	GC	TCGA-CV-7263-01A-11D-2012-08	9310784	46096158	203154463	3	44937											
LRRC41	10489	broad.mit.edu	37	chr1	46751227	46751227	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccaaagctccacaagccacTtccccaatctccatctcttc	10	10	2	19	0	2	0	0	0	2	0	8	0	5	0	6	0	2	1	6	0	3	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:46751227T>C	uc001cpn.2	-	4	1346	c.1302A>G	c.(1300-1302)GAA>GAG	p.E434E	LRRC41_uc010omb.1_Silent_p.E434E|LRRC41_uc001cpo.1_Silent_p.E434E	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	434										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					CACAAGCCACTTCCCCAATCT	0.547													34	57					0	0	0	0	C	46751227	C	C	46751227	2	2	245	1	0	0	0	0	0	0	0	1	9049	1606	56	5		5	LRRC41	1	46751227	Silent	SNP	T	TCGA-CV-7263-01A-11D-2012-08	655069	46751227	202499394	4	44938											
CYP4B1	1580	broad.mit.edu	37	chr1	47279983	47279983	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctggacattctcctgggtgCccgggtgagtacattgttgc	5	12	13	11	1	1	1	0	1	1	0	2	2	1	2	3	3	3	2	3	3	1	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:47279983C>T	uc001cqm.3	+	7	959	c.875C>T	c.(874-876)GCC>GTC	p.A292V	CYP4B1_uc009vyl.1_Missense_Mutation_p.A129V|CYP4B1_uc001cqn.3_Missense_Mutation_p.A293V|CYP4B1_uc009vym.2_Missense_Mutation_p.A278V|CYP4B1_uc010omk.1_Missense_Mutation_p.A129V|CYP4B1_uc010oml.1_Missense_Mutation_p.A130V	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	292					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CTCCTGGGTGCCCGGGTGAGT	0.582													12	16					0	0	0	0	T	47279983	T	T	47279983	3	4	245	1	0	0	0	0	1	0	0	0	4202	739	26	4	904	4	CYP4B1	1	47279983	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	528756	47279983	201970638	5	44939											
ZCCHC11	23318	broad.mit.edu	37	chr1	52940829	52940829	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcactgcttttgctggtaGaaagagatgaagagtcctgt	10	14	11	6	0	1	4	1	1	0	3	2	5	2	4	1	1	2	3	1	1	3	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:52940829G>C	uc001ctx.2	-	13	2636	c.2402C>G	c.(2401-2403)TCT>TGT	p.S801C	ZCCHC11_uc001cty.2_Missense_Mutation_p.S801C|ZCCHC11_uc001ctz.2_Missense_Mutation_p.S801C|ZCCHC11_uc009vze.1_Missense_Mutation_p.S801C|ZCCHC11_uc009vzf.1_Missense_Mutation_p.S560C|ZCCHC11_uc001cub.2_Missense_Mutation_p.S801C	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	801					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						TTTGCTGGTAGAAAGAGATGA	0.358													23	133					0	0	0	0	C	52940829	C	C	52940829	3	2	245	1	0	0	0	0	1	0	0	0	17647	942	33	2	2607	2	ZCCHC11	1	52940829	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	5660846	52940829	196309792	6	44940											
AK5	26289	broad.mit.edu	37	chr1	77806144	77806144	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaagcgtgcagaacagcAgggccgaccagacgacaatg	14	3	13	11	3	0	3	0	1	0	2	0	5	0	3	2	1	4	2	2	1	3	0			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:77806144A>G	uc001dhn.2	+	6	1039	c.782A>G	c.(781-783)CAG>CGG	p.Q261R	AK5_uc001dho.2_Missense_Mutation_p.Q235R	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	261					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						GCAGAACAGCAGGGCCGACCA	0.468													24	91					0	0	0	0	G	77806144	G	G	77806144	3	3	245	1	0	0	0	0	1	0	0	0	443	188	7	5	804	5	AK5	1	77806144	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	24865315	77806144	171444477	7	44941											
PTBP2	58155	broad.mit.edu	37	chr1	97236288	97236288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttttggaactagcaaccgagGaagcagctattactatggtt	12	12	10	7	1	0	0	0	0	0	0	0	3	0	2	1	3	6	4	1	3	7	7			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:97236288G>A	uc001drq.2	+	5	559	c.313G>A	c.(313-315)GAA>AAA	p.E105K	PTBP2_uc001drn.2_Missense_Mutation_p.E105K|PTBP2_uc001dro.2_Missense_Mutation_p.E105K|PTBP2_uc010otz.1_Missense_Mutation_p.E116K|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.E53K|PTBP2_uc001drr.2_Missense_Mutation_p.E105K|PTBP2_uc010oua.1_Missense_Mutation_p.E113K|PTBP2_uc001dru.2_RNA|PTBP2_uc001drm.2_Missense_Mutation_p.E105K	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	105	RRM 1.						nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		AGCAACCGAGGAAGCAGCTAT	0.303													21	55					0	0	0	0	A	97236288	A	A	97236288	3	1	245	1	0	0	0	0	1	0	0	0	12788	1175	41	2	331	2	PTBP2	1	97236288	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	19430144	97236288	152014333	8	44942											
PHTF1	10745	broad.mit.edu	37	chr1	114267424	114267424	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaaccaccaataatgggtaCagattccaaagtttctattc	16	11	5	9	0	1	1	0	0	1	1	3	1	2	1	3	1	2	2	3	1	7	6			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:114267424C>T	uc009wgp.1	-	6	1032	c.580G>A	c.(580-582)GTA>ATA	p.V194I	PHTF1_uc001edn.2_Missense_Mutation_p.V194I|PHTF1_uc010own.1_Missense_Mutation_p.V194I	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	194						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAATGGGTACAGATTCCAAA	0.353													25	42					0	0	0	0	T	114267424	T	T	114267424	3	4	245	1	0	0	0	0	1	0	0	0	11917	478	17	4	1760	4	PHTF1	1	114267424	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	17031136	114267424	134983197	9	44943											
WARS2	10352	broad.mit.edu	37	chr1	119683180	119683180	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggccgtctttggttacctGgagagcgggagcagctgcgg	6	8	18	9	3	1	1	0	0	1	1	1	3	1	2	2	5	5	3	2	5	1	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:119683180G>A	uc001ehn.2	-	1	116	c.88C>T	c.(88-90)CAG>TAG	p.Q30*	WARS2_uc010oxf.1_5'Flank|WARS2_uc001ehm.2_Nonsense_Mutation_p.Q30*|WARS2_uc010oxg.1_Nonsense_Mutation_p.Q30*|WARS2_uc010oxh.1_Nonsense_Mutation_p.Q30*|WARS2_uc010oxi.1_5'Flank|uc001ehp.1_RNA|uc001eho.1_RNA|uc009whk.1_RNA	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	30					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	TTGGTTACCTGGAGAGCGGGA	0.597													6	31					0	0	0	0	A	119683180	A	A	119683180	4	1	245	1	0	0	0	0	0	1	0	0	17318	1357	47	4	1047	4	WARS2	1	119683180	Nonsense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	5415756	119683180	129567441	10	44944											
OR6K2	81448	broad.mit.edu	37	chr1	158669807	158669807	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taggacatgaagatgagcatCacagctgtaataatctccac	15	9	8	9	0	2	3	1	2	1	1	3	4	2	4	1	1	2	3	1	1	4	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:158669807C>T	uc001fsu.1	-	1	636	c.636G>A	c.(634-636)GTG>GTA	p.V212V		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGATGAGCATCACAGCTGTAA	0.498													24	99					0	0	0	0	T	158669807	T	T	158669807	2	4	245	1	0	0	0	0	0	0	0	1	11256	813	29	2		2	OR6K2	1	158669807	Silent	SNP	C	TCGA-CV-7263-01A-11D-2012-08	38986627	158669807	90580814	11	44945											
LAMC1	3915	broad.mit.edu	37	chr1	183106849	183106849	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgaaagaacttttgcagaaGttacagatctggataatgag	15	11	10	5	0	1	5	0	2	1	3	1	6	1	6	0	1	3	2	0	1	5	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:183106849G>A	uc001gpy.3	+	26	4617	c.4360G>A	c.(4360-4362)GTT>ATT	p.V1454I		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	1454	Potential.|Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTTGCAGAAGTTACAGATCT	0.383													8	39					0	0	0	0	A	183106849	A	A	183106849	3	1	245	1	0	0	0	0	1	0	0	0	8654	1029	36	4	4462	4	LAMC1	1	183106849	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	24437042	183106849	66143772	12	44946											
PTPRC	5788	broad.mit.edu	37	chr1	198665840	198665840	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccattttccattaattaacaGgattgactacagcaaagatg	15	12	6	8	0	0	2	0	1	0	1	1	3	1	3	2	1	3	1	2	1	4	6			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:198665840G>A	uc001gur.1	+	4	275	c.95_splice	c.e4-1	p.G32_splice	PTPRC_uc001gus.1_Splice_Site_p.G32_splice|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Intron|PTPRC_uc009wzf.1_Intron|PTPRC_uc010ppg.1_Intron|PTPRC_uc001guu.1_Splice_Site_p.R75_splice|PTPRC_uc001guv.1_Intron|PTPRC_uc001guw.1_Intron	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C						axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TTAATTAACAGGATTGACTAC	0.418													32	83					0	0	0	0	A	198665840	A	A	198665840	5	1	245	1	0	0	0	0	0	0	1	0	12862	1014	35	4	115	4	PTPRC	1	198665840	Splice_Site	SNP	G	TCGA-CV-7263-01A-11D-2012-08	15558991	198665840	50584781	13	44947											
SOX11	6664	broad.mit.edu	37	chr2	5833737	5833737	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagggagcgagcctctacgAcgaggtgcgggccggcgcga	7	3	19	12	8	1	0	0	0	1	0	1	6	1	1	2	4	4	0	2	4	1	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:5833737A>T	uc002qyj.2	+	1	939	c.884A>T	c.(883-885)GAC>GTC	p.D295V		NM_003108	NP_003099	P35716	SOX11_HUMAN	SRY-box 11	295					cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(3)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		AGCCTCTACGACGAGGTGCGG	0.711													3	5					0	0	0	0	T	5833737	T	T	5833737	3	4	245	1	0	0	0	0	1	0	0	0	15006	275	10	5	886	5	SOX11	2	5833737	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08		5833737	237365636	14	44948											
IFT172	26160	broad.mit.edu	37	chr2	27688750	27688750	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagacctataacatcaccCtgtaaaagtttatcccccaa	14	10	3	14	0	1	1	1	0	0	1	3	1	3	1	5	0	1	2	5	0	6	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d7331dbc-eaef-46db-be3f-7e6864aaaa82	g.chr2:27688750C>A	uc002rku.2	-	17	1744	c.1693_splice	c.e17-1	p.G565_splice		NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog						cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TAACATCACCCTGTAAAAGTT	0.507													8	342					0.00307968	0.00992999	1	0	A	27688750	A	A	27688750	5	1	245	1	0	0	0	0	0	0	1	0	7596	695	24	4	3685	4	IFT172	2	27688750	Splice_Site	SNP	C	TCGA-CV-7263-01A-11D-2012-08	21855013	27688750	215510623	15	44949											
NRXN1	9378	broad.mit.edu	37	chr2	50149201	50149201	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgagttactgatgtagtttcGactctcgtccacatggtatg	8	15	10	8	2	1	2	0	2	1	0	4	3	2	2	1	1	1	4	1	1	3	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:50149201G>A	uc010fbp.2	-	6	2017	c.1210C>T	c.(1210-1212)CGA>TGA	p.R404*	NRXN1_uc002rxb.3_Nonsense_Mutation_p.R1138*|NRXN1_uc010fbq.2_Nonsense_Mutation_p.R1509*|NRXN1_uc002rxe.3_Nonsense_Mutation_p.R1439*|NRXN1_uc010yon.1_Nonsense_Mutation_p.R104*|NRXN1_uc002rxa.3_Nonsense_Mutation_p.R101*	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	404	Cytoplasmic (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding	p.R404L(1)		ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ATGTAGTTTCGACTCTCGTCC	0.478													37	60					0	0	0	0	A	50149201	A	A	50149201	4	1	245	1	0	0	0	0	0	1	0	0	10719	1066	37	1	122	1	NRXN1	2	50149201	Nonsense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	22460451	50149201	193050172	16	44950											
RNF103	7844	broad.mit.edu	37	chr2	86831161	86831161	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattctctaggcaaacaacAcattcagtacagtgcagcat	16	9	6	10	0	2	0	1	0	1	0	3	0	2	0	0	1	5	4	0	1	5	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:86831161A>C	uc002srn.2	-	4	2832	c.1863T>G	c.(1861-1863)TGT>TGG	p.C621W	VPS24_uc010ytl.1_Intron|RNF103_uc002srm.2_Missense_Mutation_p.C482W|uc002sro.2_RNA	NM_005667	NP_005658	O00237	RN103_HUMAN	ring finger protein 103	621	RING-type.			C->S: Loss of E2-dependent ubiquitination.	central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)	1						GGCAAACAACACATTCAGTAC	0.423													22	166					0	0	0	0	C	86831161	C	C	86831161	3	2	245	1	0	0	0	0	1	0	0	0	13488	157	6	5	198	5	RNF103	2	86831161	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	36681960	86831161	156368212	17	44951											
PLEKHB2	55041	broad.mit.edu	37	chr2	131890487	131890487	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccgcaggcgtatgtgggcTctgcagtcatgaccgatgag	7	9	14	11	3	2	2	1	2	1	0	3	3	3	2	2	2	1	4	2	2	1	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:131890487T>C	uc002tsg.3	+	6	906	c.346T>C	c.(346-348)TCT>CCT	p.S116P	PLEKHB2_uc002tsh.2_Missense_Mutation_p.S116P|PLEKHB2_uc002tsj.3_Missense_Mutation_p.S116P|PLEKHB2_uc002tsf.3_Missense_Mutation_p.S116P|PLEKHB2_uc010zao.1_Missense_Mutation_p.S66P|PLEKHB2_uc010zap.1_Missense_Mutation_p.S116P|PLEKHB2_uc010zaq.1_Intron|PLEKHB2_uc002tsi.3_Missense_Mutation_p.S157P	NM_001100623	NP_001094093	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B	116						membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.0828)		GTATGTGGGCTCTGCAGTCAT	0.572													31	85					0	0	0	0	C	131890487	C	C	131890487	3	2	245	1	0	0	0	0	1	0	0	0	12120	1551	54	5	364	5	PLEKHB2	2	131890487	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	45059326	131890487	111308886	18	44952											
LCT	3938	broad.mit.edu	37	chr2	136570169	136570169	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggggcgttgctgatgaggcGggaggtgtaatgcgacagac	8	8	19	6	3	0	3	0	2	0	1	0	5	0	4	0	5	2	3	0	5	1	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:136570169G>A	uc002tuu.1	-	7	2076	c.2065C>T	c.(2065-2067)CGC>TGC	p.R689C		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	689	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTGATGAGGCGGGAGGTGTAA	0.557													20	55					0	0	0	0	A	136570169	A	A	136570169	3	1	245	1	0	0	0	0	1	0	0	0	8733	1116	39	1	3762	1	LCT	2	136570169	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	4679682	136570169	106629204	19	44953											
KIF5C	3800	broad.mit.edu	37	chr2	149806405	149806405	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgacgaagctaaaaatatcaAtaagtctttgtctgctcttg	13	14	7	7	1	4	1	1	1	3	0	4	2	4	1	0	0	2	2	0	0	7	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:149806405A>G	uc010zbu.1	+	9	1135	c.767A>G	c.(766-768)AAT>AGT	p.N256S	KIF5C_uc002tws.1_RNA	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	256	Kinesin-motor.|Microtubule-binding.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		AAAAATATCAATAAGTCTTTG	0.453													9	44					0	0	0	0	G	149806405	G	G	149806405	3	3	245	1	0	0	0	0	1	0	0	0	8346	101	4	5	723	5	KIF5C	2	149806405	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	13236236	149806405	93392968	20	44954											
SP5	389058	broad.mit.edu	37	chr2	171573597	171573597	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcggagccggggaagaagAagcagcacgtgtgccacgtg	11	3	18	9	4	0	2	0	0	0	2	0	4	0	4	2	4	4	2	2	4	3	0			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:171573597A>C	uc002uge.2	+	2	1046	c.880A>C	c.(880-882)AAG>CAG	p.K294Q		NM_001003845	NP_001003845	Q6BEB4	SP5_HUMAN	Sp5 transcription factor	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGGAAGAAGAAGCAGCACGT	0.741													3	9					0	0	0	0	C	171573597	C	C	171573597	3	2	245	1	0	0	0	0	1	0	0	0	15031	247	9	5	886	5	SP5	2	171573597	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	21767192	171573597	71625776	21	44955											
MAP1D	254042	broad.mit.edu	37	chr2	172942597	172942597	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaataggatcttactttcaTggacatccagaaatttggca	13	12	9	7	0	2	1	1	0	1	1	3	4	3	4	1	4	1	1	1	4	4	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:172942597T>C	uc002uhk.2	+	7	850	c.777T>C	c.(775-777)CAT>CAC	p.H259H	MAP1D_uc010zdw.1_Silent_p.H141H	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	259		Substrate (By similarity).			N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CTTACTTTCATGGACATCCAG	0.383													22	40					0	0	0	0	C	172942597	C	C	172942597	2	2	245	1	0	0	0	0	0	0	0	1	9282	1461	51	5		5	MAP1D	2	172942597	Silent	SNP	T	TCGA-CV-7263-01A-11D-2012-08	1369000	172942597	70256776	22	44956											
AGPS	8540	broad.mit.edu	37	chr2	178388494	178388494	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggcagctgctagagaagaaAtccttgctaatggagggagc	13	7	14	7	0	0	2	0	0	0	2	1	5	1	4	1	3	4	4	1	3	4	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:178388494A>G	uc002ull.2	+	19	1863	c.1816A>G	c.(1816-1818)ATC>GTC	p.I606V	AGPS_uc010zfb.1_Missense_Mutation_p.I516V	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	606					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			TAGAGAAGAAATCCTTGCTAA	0.358													18	58					0	0	0	0	G	178388494	G	G	178388494	3	3	245	1	0	0	0	0	1	0	0	0	394	101	4	5	1890	5	AGPS	2	178388494	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	5445897	178388494	64810879	23	44957											
NDUFS1	4719	broad.mit.edu	37	chr2	206988923	206988923	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaagcttcagcatatggatgGttcctctactgcctgggcac	8	11	11	11	0	2	0	1	0	1	0	3	2	3	1	2	3	4	4	2	3	3	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:206988923G>A	uc002vbe.2	-	19	2297	c.2170C>T	c.(2170-2172)CCA>TCA	p.P724S	NDUFS1_uc010ziq.1_Missense_Mutation_p.P738S|NDUFS1_uc010zir.1_Missense_Mutation_p.P688S|NDUFS1_uc010zis.1_Missense_Mutation_p.P667S|NDUFS1_uc010zit.1_Missense_Mutation_p.P613S|NDUFS1_uc010ziu.1_Missense_Mutation_p.P608S	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	724					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	CATATGGATGGTTCCTCTACT	0.418													15	46					0	0	0	0	A	206988923	A	A	206988923	3	1	245	1	0	0	0	0	1	0	0	0	10345	1261	44	4	17	4	NDUFS1	2	206988923	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	28600429	206988923	36210450	24	44958											
ANKZF1	55139	broad.mit.edu	37	chr2	220098107	220098107	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccgaggtgggccatcacaCtctgctggagccaacctgag	8	6	13	14	1	2	1	1	1	1	0	2	3	2	2	4	3	3	1	4	3	1	0			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:220098107C>T	uc002vkg.2	+	7	945	c.771C>T	c.(769-771)CAC>CAT	p.H257H	ANKZF1_uc010zkv.1_Silent_p.H201H|ANKZF1_uc010zkw.1_Silent_p.H47H|ANKZF1_uc002vkh.2_Silent_p.H47H|ANKZF1_uc002vki.2_Silent_p.H257H|ANKZF1_uc002vkj.1_Silent_p.H245H	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	257						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCCATCACACTCTGCTGGAG	0.522													17	52					0	0	0	0	T	220098107	T	T	220098107	2	4	245	1	0	0	0	0	0	0	0	1	693	564	20	4		4	ANKZF1	2	220098107	Silent	SNP	C	TCGA-CV-7263-01A-11D-2012-08	13109184	220098107	23101266	25	44959											
ALPPL2	251	broad.mit.edu	37	chr2	233272011	233272011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcagggatgggggtgtctaCggtgacagctgccaggatcc	7	9	16	9	1	2	1	1	1	1	0	3	3	3	3	2	5	3	1	2	5	1	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:233272011C>T	uc002vss.3	+	3	253	c.200C>T	c.(199-201)ACG>ATG	p.T67M		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	67					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GGGGTGTCTACGGTGACAGCT	0.627													22	59					0	0	0	0	T	233272011	T	T	233272011	3	4	245	1	0	0	0	0	1	0	0	0	549	536	19	1	210	1	ALPPL2	2	233272011	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	13173904	233272011	9927362	26	44960											
CSPG5	10675	broad.mit.edu	37	chr3	47618893	47618893	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttcgaagtagtcgatgtcaAtgatatctgatgccggttgg	9	13	12	7	3	2	2	1	2	1	0	4	4	2	2	1	2	1	2	1	2	4	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr3:47618893A>T	uc003crp.3	-	2	799	c.623T>A	c.(622-624)ATT>AAT	p.I208N	CSPG5_uc003crn.2_Missense_Mutation_p.I70N|CSPG5_uc003cro.3_Missense_Mutation_p.I208N|CSPG5_uc011bbb.1_Missense_Mutation_p.I70N	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	208	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GTCGATGTCAATGATATCTGA	0.587													13	24					0	0	0	0	T	47618893	T	T	47618893	3	4	245	1	0	0	0	0	1	0	0	0	3978	101	4	5	1012	5	CSPG5	3	47618893	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08		47618893	150403537	27	44961											
MST1R	4486	broad.mit.edu	37	chr3	49933239	49933239	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcagcaggataccaaggagCgtgctctgtgggaccccatc	9	6	14	12	1	1	0	0	0	1	0	2	3	1	3	3	4	4	3	3	4	2	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr3:49933239C>T	uc003cxy.3	-	12	3135	c.2871G>A	c.(2869-2871)ACG>ACA	p.T957T	MST1R_uc011bdc.1_5'UTR	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	957	Extracellular (Potential).				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TACCAAGGAGCGTGCTCTGTG	0.607													6	46					0	0	0	0	T	49933239	T	T	49933239	2	4	245	1	0	0	0	0	0	0	0	1	9944	755	27	1		1	MST1R	3	49933239	Silent	SNP	C	TCGA-CV-7263-01A-11D-2012-08	2314346	49933239	148089191	28	44962											
BAP1	8314	broad.mit.edu	37	chr3	52439912	52439913	+	Frame_Shift_Del	DEL	TG	-	-																															gggtctgaatcagctctggcTgtgttactcttatcagctaa																										TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr3:52439912_52439913delTG	uc003ddx.2	-	10	914_915	c.799_800delCA	c.(799-801)CAGfs	p.Q267fs	BAP1_uc003ddw.2_5'Flank|BAP1_uc010hmg.2_5'Flank|BAP1_uc010hmh.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	267					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CAGCTCTGGCTGTGTTACTCTT	0.52			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								---	---	---								-	52439913	-	-	52439912	7	5	245	1	0	1	0	1	0	0	0	0	1313	1580	55	0	1421	0	BAP1	3	52439912	Frame_Shift_Del	DEL	TG	TCGA-CV-7263-01A-11D-2012-08	2506673	52439912	145582518	29	44963											
PHLDB2	90102	broad.mit.edu	37	chr3	111686631	111686631	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagccagaggcagaagttaaTagaaaaggaagtaaaaataa	22	6	10	3	0	0	3	0	0	0	3	0	4	0	4	1	2	1	3	1	2	11	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr3:111686631T>A	uc010hqa.2	+	15	3686	c.3275T>A	c.(3274-3276)ATA>AAA	p.I1092K	PHLDB2_uc003dyc.2_Missense_Mutation_p.I1076K|PHLDB2_uc003dyd.2_Missense_Mutation_p.I1049K|PHLDB2_uc003dyg.2_Missense_Mutation_p.I1092K|PHLDB2_uc003dyh.2_Missense_Mutation_p.I1049K|PHLDB2_uc003dyi.2_Missense_Mutation_p.I583K|PHLDB2_uc003dyj.2_Missense_Mutation_p.I147K	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1092	Potential.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						CAGAAGTTAATAGAAAAGGAA	0.468											OREG0015707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	29					0	0	0	0	A	111686631	A	A	111686631	3	1	245	1	0	0	0	0	1	0	0	0	11907	1406	49	5	3414	5	PHLDB2	3	111686631	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	59246719	111686631	86335799	30	44964											
PLXNA1	5361	broad.mit.edu	37	chr3	126752808	126752808	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgagcaggcgcggcggcagcGgctgcggagcaagctggagc	7	3	20	11	5	0	1	0	1	0	0	0	3	0	3	0	6	6	5	0	6	1	0			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr3:126752808G>A	uc003ejg.2	+	31	5574	c.5570G>A	c.(5569-5571)CGG>CAG	p.R1857Q	PLXNA1_uc003ejh.2_Missense_Mutation_p.R525Q	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1880	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CGGCGGCAGCGGCTGCGGAGC	0.652													4	16					0	0	0	0	A	126752808	A	A	126752808	3	1	245	1	0	0	0	0	1	0	0	0	12174	1116	39	1	5761	1	PLXNA1	3	126752808	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	15066177	126752808	71269622	31	44965											
ZNF595	152687	broad.mit.edu	37	chr4	86195	86195	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtggcaaagcctttacaagGtccacaacactgaatgaaca	15	8	8	10	0	0	2	0	2	0	0	1	2	1	2	2	2	4	1	2	2	6	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:86195G>C	uc003fzv.1	+	6	957	c.801G>C	c.(799-801)AGG>AGC	p.R267S	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_Missense_Mutation_p.R35S|ZNF595_uc011but.1_Missense_Mutation_p.R35S	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	267					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		CCTTTACAAGGTCCACAACAC	0.408													40	21					0	0	0	0	C	86195	C	C	86195	3	2	245	1	0	0	0	0	1	0	0	0	18092	1261	44	4	814	4	ZNF595	4	86195	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08		86195	191068081	32	44966											
TACC3	10460	broad.mit.edu	37	chr4	1746264	1746264	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaacgaagagtcactgaagaAgtgcgtggaggattacctgg	13	7	15	6	2	1	3	1	1	0	2	1	7	1	5	1	3	3	0	1	3	5	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:1746264A>G	uc003gdo.2	+	14	2351	c.2243A>G	c.(2242-2244)AAG>AGG	p.K748R	TACC3_uc003gdp.2_Missense_Mutation_p.K388R|TACC3_uc010ica.2_Missense_Mutation_p.K169R	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	748	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			TCACTGAAGAAGTGCGTGGAG	0.612													41	21					0	0	0	0	G	1746264	G	G	1746264	3	3	245	1	0	0	0	0	1	0	0	0	15569	72	3	5	2293	5	TACC3	4	1746264	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	1660069	1746264	189408012	33	44967											
RBPJ	3516	broad.mit.edu	37	chr4	26407892	26407892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcatatggaaatgaaaaaaGgtaagattatttttctggtg	15	14	10	2	0	2	2	1	1	1	1	2	3	2	3	0	3	0	1	0	3	7	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:26407892G>A	uc003grx.1	+	4	430	c.194G>A	c.(193-195)AGG>AAG	p.R65K	RBPJ_uc003gry.1_Missense_Mutation_p.R50K|RBPJ_uc003grz.1_Missense_Mutation_p.R65K|RBPJ_uc011bxt.1_Missense_Mutation_p.R65K|RBPJ_uc003gsa.1_Missense_Mutation_p.R51K|RBPJ_uc003gsb.1_Missense_Mutation_p.R52K|RBPJ_uc003gsc.1_Missense_Mutation_p.R51K	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	65					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				AATGAAAAAAGGTAAGATTAT	0.333													56	37					0	0	0	0	A	26407892	A	A	26407892	3	1	245	1	0	0	0	0	1	0	0	0	13226	1014	35	4	267	4	RBPJ	4	26407892	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	24661628	26407892	164746384	34	44968											
UGT2B11	10720	broad.mit.edu	37	chr4	70080272	70080272	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aagaatggaagctgaagatgCcagtacagtcacctcatgac	15	7	10	9	0	2	4	2	2	0	2	2	5	2	5	2	1	3	2	2	1	5	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:70080272C>G	uc003heh.2	-	1	178	c.169G>C	c.(169-171)GCA>CCA	p.A57P	uc003hei.1_RNA	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	57					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						GCTGAAGATGCCAGTACAGTC	0.393													17	214					0	0	0	0	G	70080272	G	G	70080272	3	3	245	1	0	0	0	0	1	0	0	0	17025	739	26	4	1444	4	UGT2B11	4	70080272	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	43672380	70080272	121074004	35	44969											
FBXW7	55294	broad.mit.edu	37	chr4	153251878	153251886	+	Splice_Site	DEL	AGTTACCTT	-	-																															tgttacattgtgcagagttcAgttaccttaggagatttgag																										TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:153251878_153251886delAGTTACCTT	uc003ims.2	-	7	1271	c.1122_splice	c.e7+1	p.K374_splice	FBXW7_uc011cii.1_Splice_Site_p.K374_splice|FBXW7_uc003imt.2_Splice_Site_p.K374_splice|FBXW7_uc011cih.1_Splice_Site_p.K198_splice|FBXW7_uc003imq.2_Splice_Site_p.K294_splice|FBXW7_uc003imr.2_Splice_Site_p.K256_splice	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform						interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGCAGAGTTCAGTTACCTTAGGAGATTTG	0.388			Mis|N|D|F		colorectal|endometrial|T-ALL								---	---	---								-	153251886	-	-	153251878	8	5	245	1	0	1	0	1	0	0	1	0	5801	203	7	0		0	FBXW7	4	153251878	Splice_Site	DEL	AGTTACCTT	TCGA-CV-7263-01A-11D-2012-08	83171606	153251878	37902398	36	44970											
RXFP1	59350	broad.mit.edu	37	chr4	159573014	159573014	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttaaagaaatgattcatcGgttttggtataactacagac	15	14	7	5	1	1	3	1	1	0	2	2	3	1	3	0	2	2	2	0	2	6	8			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:159573014G>A	uc003ipz.2	+	18	2163	c.2081G>A	c.(2080-2082)CGG>CAG	p.R694Q	RXFP1_uc011cja.1_Missense_Mutation_p.R589Q|RXFP1_uc010iqo.2_Missense_Mutation_p.R646Q|RXFP1_uc011cjb.1_Missense_Mutation_p.R592Q|RXFP1_uc010iqk.2_Missense_Mutation_p.R562Q|RXFP1_uc011cjc.1_Missense_Mutation_p.R613Q|RXFP1_uc011cjd.1_Missense_Mutation_p.R613Q|RXFP1_uc010iql.2_Missense_Mutation_p.R538Q|RXFP1_uc011cje.1_Missense_Mutation_p.R721Q|RXFP1_uc010iqm.2_Missense_Mutation_p.R661Q|RXFP1_uc011cjf.1_Missense_Mutation_p.R563Q|RXFP1_uc010iqn.2_Missense_Mutation_p.R639Q	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	694	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		ATGATTCATCGGTTTTGGTAT	0.393													21	54					0	0	0	0	A	159573014	A	A	159573014	3	1	245	1	0	0	0	0	1	0	0	0	13824	1116	39	1	2151	1	RXFP1	4	159573014	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	6321136	159573014	31581262	37	44971											
FAT1	2195	broad.mit.edu	37	chr4	187540845	187540845	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacttgaacaacagacgttcCaattacagatgcctcagaca	16	8	6	11	1	1	4	1	1	0	3	2	4	2	4	2	0	5	1	2	0	5	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:187540845C>A	uc003izf.2	-	10	7083	c.6895G>T	c.(6895-6897)GGA>TGA	p.G2299*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2299	Extracellular (Potential).|Cadherin 21.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACAGACGTTCCAATTACAGAT	0.433										HNSCC(5;0.00058)			82	54					1.15773e-35	4.48025e-35	1	0	A	187540845	A	A	187540845	4	1	245	1	0	0	0	0	0	1	0	0	5721	603	21	4	6943	4	FAT1	4	187540845	Nonsense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	27967831	187540845	3613431	38	44972											
DNAH5	1767	broad.mit.edu	37	chr5	13817734	13817734	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catttgtggcaacgtccagcCgaccaaacatctgtggggca	10	8	11	12	2	1	0	0	0	1	0	2	1	2	0	3	3	3	2	3	3	2	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr5:13817734C>T	uc003jfd.2	-	42	6953	c.6911G>A	c.(6910-6912)CGG>CAG	p.R2304Q		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2304	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AACGTCCAGCCGACCAAACAT	0.403									Kartagener_syndrome				27	48					0	0	0	0	T	13817734	T	T	13817734	3	4	245	1	0	0	0	0	1	0	0	0	4626	652	23	1	7115	1	DNAH5	5	13817734	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08		13817734	167097526	39	44973											
MYO10	4651	broad.mit.edu	37	chr5	16682073	16682073	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctcctccggcgtgtcggCgttgcagtgcagcacccggt	4	9	13	15	5	1	0	0	0	1	0	4	0	2	0	3	3	3	4	3	3	0	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr5:16682073C>T	uc003jft.3	-	31	4564	c.4096G>A	c.(4096-4098)GCC>ACC	p.A1366T	MYO10_uc011cnb.1_5'UTR|MYO10_uc011cnc.1_Missense_Mutation_p.A245T|MYO10_uc011cnd.1_Missense_Mutation_p.A723T|MYO10_uc011cne.1_Missense_Mutation_p.A723T|MYO10_uc010itx.2_Missense_Mutation_p.A988T	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1366					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						GGCGTGTCGGCGTTGCAGTGC	0.577													22	110					0	0	0	0	T	16682073	T	T	16682073	3	4	245	1	0	0	0	0	1	0	0	0	10115	768	27	1	2124	1	MYO10	5	16682073	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	2864339	16682073	164233187	40	44974											
MCCC2	64087	broad.mit.edu	37	chr5	70927976	70927976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaactggggaagaagtatCtgctgaggatcttggaggtg	10	9	17	5	0	2	2	0	1	2	1	2	5	2	5	0	6	2	3	0	6	4	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr5:70927976C>T	uc003kbs.3	+	8	905	c.767C>T	c.(766-768)TCT>TTT	p.S256F	MCCC2_uc010iyv.1_Missense_Mutation_p.S256F|MCCC2_uc003kbt.3_RNA|MCCC2_uc003kbu.1_Missense_Mutation_p.S125F	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	256	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	GAAGAAGTATCTGCTGAGGAT	0.398													18	70					0	0	0	0	T	70927976	T	T	70927976	3	4	245	1	0	0	0	0	1	0	0	0	9428	913	32	2	797	2	MCCC2	5	70927976	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	54245903	70927976	109987284	41	44975											
PRPF4B	8899	broad.mit.edu	37	chr6	4052307	4052307	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatcacaagcagcatctttGtctggtattcgagcctctca	9	13	7	12	1	4	0	2	0	3	0	6	1	4	0	1	1	3	3	1	1	3	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:4052307G>A	uc003mvv.2	+	10	2382	c.2291G>A	c.(2290-2292)TGT>TAT	p.C764Y	PRPF4B_uc003mvw.2_RNA|C6orf146_uc010jnq.1_Intron|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	764	Protein kinase.					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CAGCATCTTTGTCTGGTATTC	0.353													20	38					0	0	0	0	A	4052307	A	A	4052307	3	1	245	1	0	0	0	0	1	0	0	0	12635	1377	48	4	2329	4	PRPF4B	6	4052307	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08		4052307	167062760	42	44976											
HIST1H4B	8366	broad.mit.edu	37	chr6	26027417	26027417	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggatgttatcccgcagcaCttttcggtgacgcttggcac	6	13	11	11	3	0	1	0	1	0	0	2	2	1	2	1	3	1	5	1	3	1	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:26027417C>T	uc003nfr.2	-	1	64	c.64G>A	c.(64-66)GTG>ATG	p.V22M		NM_003544	NP_003535	P62805	H4_HUMAN	histone cluster 1, H4b	22					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						TCCCGCAGCACTTTTCGGTGA	0.532													10	64					0	0	0	0	T	26027417	T	T	26027417	3	4	245	1	0	0	0	0	1	0	0	0	7205	565	20	4	251	4	HIST1H4B	6	26027417	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	21975110	26027417	145087650	43	44977											
HIST1H3I	8354	broad.mit.edu	37	chr6	27839984	27839984	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcggtagcggtggggcttcTtgacgccaccggtggccgga	4	7	19	11	5	1	1	0	1	1	0	1	2	1	2	3	8	1	2	3	8	1	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:27839984T>A	uc003njy.2	-	1	116	c.110A>T	c.(109-111)AAG>ATG	p.K37M		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	37					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GTGGGGCTTCTTGACGCCACC	0.672													16	68					0	0	0	0	A	27839984	A	A	27839984	3	1	245	1	0	0	0	0	1	0	0	0	7202	1609	56	5	304	5	HIST1H3I	6	27839984	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	1812567	27839984	143275083	44	44978											
MAPK13	5603	broad.mit.edu	37	chr6	36106785	36106785	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacggaggcccagcagccgtTtgatgattccttagaacacg	10	8	12	11	3	0	3	0	2	0	1	1	5	1	4	3	2	3	2	3	2	2	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:36106785T>C	uc003ols.2	+	11	1069	c.971T>C	c.(970-972)TTT>TCT	p.F324S	MAPK13_uc003olt.2_RNA	NM_002754	NP_002745	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	324					cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3						CAGCAGCCGTTTGATGATTCC	0.602													15	39					0	0	0	0	C	36106785	C	C	36106785	3	2	245	1	0	0	0	0	1	0	0	0	9328	1841	64	5	1013	5	MAPK13	6	36106785	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	8266801	36106785	135008282	45	44979											
NR2E1	7101	broad.mit.edu	37	chr6	108502785	108502785	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctgaactgagaagtttcCggaatgctgccgccattgca	9	11	11	10	2	1	2	0	2	1	1	2	4	2	3	3	1	4	4	3	1	3	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:108502785C>T	uc003psg.2	+	8	1680	c.925C>T	c.(925-927)CGG>TGG	p.R309W		NM_003269	NP_003260	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	309	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		GAGAAGTTTCCGGAATGCTGC	0.438													16	60					0	0	0	0	T	108502785	T	T	108502785	3	4	245	1	0	0	0	0	1	0	0	0	10679	643	23	1	955	1	NR2E1	6	108502785	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	72396000	108502785	62612282	46	44980											
PDE10A	10846	broad.mit.edu	37	chr6	165806230	165806230	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagttgtgataaggaacccGccgatagttcttcttcacag	10	11	9	11	2	3	1	1	1	2	0	3	3	3	2	3	1	1	2	3	1	3	6			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:165806230G>A	uc003qun.2	-	17	1772	c.1531C>T	c.(1531-1533)CGG>TGG	p.R511W	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.R441W|PDE10A_uc003quo.2_Missense_Mutation_p.R521W	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	511					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TAAGGAACCCGCCGATAGTTC	0.428													6	41					0	0	0	0	A	165806230	A	A	165806230	3	1	245	1	0	0	0	0	1	0	0	0	11684	1086	38	1	836	1	PDE10A	6	165806230	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	57303445	165806230	5308837	47	44981											
ZFAND2A	90637	broad.mit.edu	37	chr7	1197817	1197817	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgcttgcaagtcttttctGaacaatgcttccccaaatca	10	13	6	12	0	3	1	1	1	2	0	4	1	4	1	2	0	4	4	2	0	4	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:1197817G>A	uc003skc.2	-	2	333	c.32C>T	c.(31-33)TCA>TTA	p.S11L	ZFAND2A_uc003skd.3_Missense_Mutation_p.S11L|uc003skf.1_5'Flank	NM_182491	NP_872297	Q8N6M9	ZFN2A_HUMAN	zinc finger, AN1-type domain 2A	11	AN1-type 1.					cytoplasm|nucleus	zinc ion binding			ovary(1)	1		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.82e-15)		AGTCTTTTCTGAACAATGCTT	0.398													8	398					0	0	0	0	A	1197817	A	A	1197817	3	1	245	1	0	0	0	0	1	0	0	0	17694	1294	45	2	421	2	ZFAND2A	7	1197817	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08		1197817	157940846	48	44982											
ZNF12	7559	broad.mit.edu	37	chr7	6731206	6731206	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctctcctgaatgagttctaTaatgtacagtgagatatgac	12	14	8	7	0	2	4	0	4	2	1	4	5	3	4	1	0	1	2	1	0	5	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:6731206T>C	uc003sqt.1	-	5	1921	c.1367A>G	c.(1366-1368)TAT>TGT	p.Y456C	ZNF12_uc011jxa.1_Missense_Mutation_p.Y294C|ZNF12_uc003sqs.1_Missense_Mutation_p.Y418C	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	456	C2H2-type 7.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		ATGAGTTCTATAATGTACAGT	0.433													17	49					0	0	0	0	C	6731206	C	C	6731206	3	2	245	1	0	0	0	0	1	0	0	0	17785	1406	49	5	730	5	ZNF12	7	6731206	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	5533389	6731206	152407457	49	44983											
HOXA11	3207	broad.mit.edu	37	chr7	27224479	27224479	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgccggccgcgctgggcgcCtgcaggcagtctctgtgcac	4	6	15	16	5	1	0	0	0	1	0	2	0	1	0	3	3	2	4	3	3	0	0			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:27224479C>A	uc003syx.2	-	1	357	c.285G>T	c.(283-285)CAG>CAT	p.Q95H	HOXA11_uc003syy.2_RNA|HOXA11AS_uc003syz.1_5'Flank	NM_005523	NP_005514	P31270	HXA11_HUMAN	homeobox A11	95					branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)	2						CGCTGGGCGCCTGCAGGCAGT	0.657			T	NUP98	CML								15	54					6.72482e-11	2.49969e-10	1	0	A	27224479	A	A	27224479	3	1	245	1	0	0	0	0	1	0	0	0	7329	680	24	4	664	4	HOXA11	7	27224479	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	20493273	27224479	131914184	50	44984											
PCLO	27445	broad.mit.edu	37	chr7	82585666	82585666	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atactcatcactgcttgatgAgccaacactagttcttcgtt	10	14	6	11	1	3	2	2	2	1	0	4	2	3	2	1	0	4	3	1	0	3	6			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:82585666A>G	uc003uhx.2	-	5	4892	c.4603T>C	c.(4603-4605)TCA>CCA	p.S1535P	PCLO_uc003uhv.2_Missense_Mutation_p.S1535P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1466					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGCTTGATGAGCCAACACTA	0.403													6	83					0	0	0	0	G	82585666	G	G	82585666	3	3	245	1	0	0	0	0	1	0	0	0	11637	304	11	5	10926	5	PCLO	7	82585666	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	55361187	82585666	76552997	51	44985											
ZNF804B	219578	broad.mit.edu	37	chr7	88964789	88964789	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcatctattgtgattctaaCtcacagatttcctgtactgg	10	16	6	9	0	4	2	2	1	2	1	5	2	5	2	1	1	2	1	1	1	3	6			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:88964789C>T	uc011khi.1	+	4	3031	c.2493C>T	c.(2491-2493)AAC>AAT	p.N831N		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	831						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GTGATTCTAACTCACAGATTT	0.373										HNSCC(36;0.09)			14	43					0	0	0	0	T	88964789	T	T	88964789	2	4	245	1	0	0	0	0	0	0	0	1	18238	564	20	4		4	ZNF804B	7	88964789	Silent	SNP	C	TCGA-CV-7263-01A-11D-2012-08	6379123	88964789	70173874	52	44986											
MUC17	140453	broad.mit.edu	37	chr7	100678303	100678303	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagccagttcacctcctccAactgctgaagttaccagcat	11	9	7	14	0	1	1	1	1	0	0	3	2	3	1	5	0	5	4	5	0	4	2	rs140408252		TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:100678303A>C	uc003uxp.1	+	3	3659	c.3606A>C	c.(3604-3606)CCA>CCC	p.P1202P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1202	Extracellular (Potential).|Ser-rich.|18.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACCTCCTCCAACTGCTGAAG	0.522													56	613					0	0	0	0	C	100678303	C	C	100678303	2	2	245	1	0	0	0	0	0	0	0	1	10027	117	5	5		5	MUC17	7	100678303	Silent	SNP	A	TCGA-CV-7263-01A-11D-2012-08	11713514	100678303	58460360	53	44987											
FBXL13	222235	broad.mit.edu	37	chr7	102453908	102453908	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccttccctatcatagccaaAccaacgtggagggtcattag	11	10	8	12	1	2	0	2	0	0	0	4	1	4	1	4	2	3	0	4	2	5	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:102453908A>G	uc003vaq.2	-	20	2516	c.2089T>C	c.(2089-2091)TTT>CTT	p.F697L	FBXL13_uc010liq.1_Missense_Mutation_p.F230L|FBXL13_uc010lir.1_Missense_Mutation_p.F652L|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.F669L|FAM185A_uc011klh.1_Intron	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	697											0						TCATAGCCAAACCAACGTGGA	0.408													12	117					0	0	0	0	G	102453908	G	G	102453908	3	3	245	1	0	0	0	0	1	0	0	0	5741	43	2	5	122	5	FBXL13	7	102453908	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	1775605	102453908	56684755	54	44988											
ABP1	26	broad.mit.edu	37	chr7	150556008	150556008	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaaaggaagctgcctaagtaCctgctctttaccagccccca	12	8	7	14	0	1	0	0	0	1	0	1	1	1	1	5	1	6	3	5	1	6	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:150556008C>T	uc003why.1	+	4	5946	c.1728C>T	c.(1726-1728)TAC>TAT	p.Y576Y	ABP1_uc003whz.1_Silent_p.Y576Y|ABP1_uc003wia.1_Silent_p.Y576Y	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	576					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	TGCCTAAGTACCTGCTCTTTA	0.652													5	36					0	0	0	0	T	150556008	T	T	150556008	2	4	245	1	0	0	0	0	0	0	0	1	98	518	18	4		4	ABP1	7	150556008	Silent	SNP	C	TCGA-CV-7263-01A-11D-2012-08	48102100	150556008	8582655	55	44989											
DPP6	1804	broad.mit.edu	37	chr7	154172049	154172049	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gataatagtctgtctcaaaaGaagaaggtcactgtagaaga	17	9	10	5	0	3	4	2	0	2	4	4	5	3	4	0	1	0	1	0	1	8	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:154172049G>T	uc003wlk.2	+	3	513	c.384G>T	c.(382-384)AAG>AAT	p.K128N	DPP6_uc003wli.2_Missense_Mutation_p.K64N|DPP6_uc003wlj.2_Missense_Mutation_p.K128N|DPP6_uc010lqh.1_Missense_Mutation_p.K66N|DPP6_uc003wlm.2_Missense_Mutation_p.K66N|DPP6_uc011kvq.1_Missense_Mutation_p.K66N	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	128	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TGTCTCAAAAGAAGAAGGTCA	0.378													17	48					3.99206e-14	1.52399e-13	1	0	T	154172049	T	T	154172049	3	4	245	1	0	0	0	0	1	0	0	0	4752	933	33	2	510	2	DPP6	7	154172049	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	3616041	154172049	4966614	56	44990											
DPP6	1804	broad.mit.edu	37	chr7	154561189	154561189	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcacgagactcgcctacGccgccatcaatgattcccgt	9	8	9	15	5	1	2	1	1	0	1	3	3	2	2	4	1	1	1	4	1	2	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:154561189G>A	uc003wlk.2	+	9	1075	c.946G>A	c.(946-948)GCC>ACC	p.A316T	DPP6_uc003wli.2_Missense_Mutation_p.A252T|DPP6_uc003wlm.2_Missense_Mutation_p.A254T|DPP6_uc011kvq.1_Missense_Mutation_p.A209T	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	316	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			ACTCGCCTACGCCGCCATCAA	0.522													12	65					0	0	0	0	A	154561189	A	A	154561189	3	1	245	1	0	0	0	0	1	0	0	0	4752	1087	38	1	1096	1	DPP6	7	154561189	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	389140	154561189	4577474	57	44991											
IDO1	3620	broad.mit.edu	37	chr8	39775722	39775722	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaaggtcatggagatgtccGtaaggtttggagattttctc	10	13	12	6	1	2	2	1	0	1	2	4	4	3	2	1	4	0	2	1	4	2	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr8:39775722G>A	uc003xnm.2	+	3	413	c.299G>A	c.(298-300)CGT>CAT	p.R100H	IDO1_uc003xnn.2_RNA	NM_002164	NP_002155	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	100					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)	2					L-Tryptophan(DB00150)	GGAGATGTCCGTAAGGTTTGG	0.393													16	80					0	0	0	0	A	39775722	A	A	39775722	3	1	245	1	0	0	0	0	1	0	0	0	7540	1145	40	1	309	1	IDO1	8	39775722	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08		39775722	106588300	58	44992											
SLCO5A1	81796	broad.mit.edu	37	chr8	70674022	70674022	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctggtcaaggtgaacaggAtttctgggatcaacataaaa	14	11	10	6	0	4	1	2	1	2	0	4	3	4	3	0	4	2	0	0	4	5	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr8:70674022A>G	uc003xyl.2	-	3	1703	c.996T>C	c.(994-996)AAT>AAC	p.N332N	SLCO5A1_uc010lzb.2_Silent_p.N332N|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Silent_p.N332N|SLCO5A1_uc010lzc.2_Silent_p.N332N	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	332	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GGTGAACAGGATTTCTGGGAT	0.378													4	55					0	0	0	0	G	70674022	G	G	70674022	2	3	245	1	0	0	0	0	0	0	0	1	14795	330	12	5		5	SLCO5A1	8	70674022	Silent	SNP	A	TCGA-CV-7263-01A-11D-2012-08	30898300	70674022	75690000	59	44993											
SNTB1	6641	broad.mit.edu	37	chr8	121706116	121706116	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatactggggatcctttctTcacatagggcgtggcttctc	6	13	12	10	1	3	0	1	0	2	0	5	2	4	2	1	5	1	1	1	5	2	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr8:121706116T>C	uc010mdg.2	-	2	830	c.604A>G	c.(604-606)AAG>GAG	p.K202E	SNTB1_uc003ype.2_Missense_Mutation_p.K202E	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	202	PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			GATCCTTTCTTCACATAGGGC	0.517													21	86					0	0	0	0	C	121706116	C	C	121706116	3	2	245	1	0	0	0	0	1	0	0	0	14936	1792	62	5	1036	5	SNTB1	8	121706116	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	51032094	121706116	24657906	60	44994											
LRRC6	23639	broad.mit.edu	37	chr8	133596002	133596002	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catagatttgaatgctcgctGaccacctgtgattacttctc	9	14	7	11	1	1	4	0	3	1	1	3	4	1	4	2	0	2	2	2	0	3	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr8:133596002G>A	uc003ytk.2	-	11	1239	c.1165C>T	c.(1165-1167)CAG>TAG	p.Q389*	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	389	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			AATGCTCGCTGACCACCTGTG	0.378													33	42					0	0	0	0	A	133596002	A	A	133596002	4	1	245	1	0	0	0	0	0	1	0	0	9066	1299	45	2	243	2	LRRC6	8	133596002	Nonsense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	11889886	133596002	12768020	61	44995											
NFX1	4799	broad.mit.edu	37	chr9	33294473	33294473	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attcctcaggagaaaaaaaaTtctggtctaaattgtgggac	15	11	9	6	0	3	1	1	0	2	1	4	3	4	2	1	3	0	0	1	3	6	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr9:33294473T>A	uc003zsq.2	+	2	142	c.81T>A	c.(79-81)AAT>AAA	p.N27K	SUGT1P1_uc010mjq.1_Intron|NFX1_uc011lnw.1_Missense_Mutation_p.N27K|NFX1_uc003zso.2_Missense_Mutation_p.N27K|NFX1_uc003zsp.1_Missense_Mutation_p.N27K|NFX1_uc010mjr.1_Missense_Mutation_p.N27K|NFX1_uc003zsr.2_Missense_Mutation_p.N27K	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	27					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		AGAAAAAAAATTCTGGTCTAA	0.383													84	104					0	0	0	0	A	33294473	A	A	33294473	3	1	245	1	0	0	0	0	1	0	0	0	10441	1490	52	5	87	5	NFX1	9	33294473	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08		33294473	107918958	62	44996											
VPS13A	23230	broad.mit.edu	37	chr9	79955422	79955422	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcaaataccatatatcagtgGctgaagaaggaaatgataaa	19	8	9	5	0	1	3	1	2	0	1	1	4	1	4	1	2	1	2	1	2	9	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr9:79955422G>A	uc004akr.2	+	50	7242	c.6982G>A	c.(6982-6984)GCT>ACT	p.A2328T	VPS13A_uc004akp.3_Missense_Mutation_p.A2328T|VPS13A_uc004akq.3_Missense_Mutation_p.A2328T|VPS13A_uc004aks.2_Missense_Mutation_p.A2289T	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2328					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						TATATCAGTGGCTGAAGAAGG	0.338													17	56					0	0	0	0	A	79955422	A	A	79955422	3	1	245	1	0	0	0	0	1	0	0	0	17257	1203	42	4	7180	4	VPS13A	9	79955422	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	46660949	79955422	61258009	63	44997											
OR1L8	138881	broad.mit.edu	37	chr9	125330736	125330736	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataaactcggagacactgctGgtgtggttgattctttccat	9	14	10	8	1	1	2	0	1	1	1	3	3	2	2	1	3	2	2	1	3	2	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr9:125330736G>T	uc004bmp.1	-	1	21	c.21C>A	c.(19-21)ACC>ACA	p.T7T		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3						AGACACTGCTGGTGTGGTTGA	0.448													7	54					2.74318e-10	1.013e-09	1	0	T	125330736	T	T	125330736	2	4	245	1	0	0	0	0	0	0	0	1	11021	1335	47	4		4	OR1L8	9	125330736	Silent	SNP	G	TCGA-CV-7263-01A-11D-2012-08	45375314	125330736	15882695	64	44998											
ODF2	4957	broad.mit.edu	37	chr9	131247076	131247076	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggagaccgagacaaagagAgcttgaagaaggccatccga	16	3	14	8	2	0	5	0	1	0	4	1	9	1	5	3	2	1	1	3	2	3	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr9:131247076A>T	uc011mbd.1	+	12	1512	c.1201A>T	c.(1201-1203)AGC>TGC	p.S401C	ODF2_uc011maz.1_Missense_Mutation_p.S401C|ODF2_uc010myb.2_Missense_Mutation_p.S377C|ODF2_uc011mbb.1_Missense_Mutation_p.S335C|ODF2_uc011mbc.1_Missense_Mutation_p.S320C|ODF2_uc004bva.2_Missense_Mutation_p.S354C|ODF2_uc004bvb.2_Missense_Mutation_p.S377C|ODF2_uc011mbe.1_Missense_Mutation_p.S396C|ODF2_uc004bvc.2_Missense_Mutation_p.S377C|ODF2_uc010myc.2_Missense_Mutation_p.S344C|ODF2_uc011mbf.1_Missense_Mutation_p.S382C|ODF2_uc004bvd.3_Missense_Mutation_p.S401C|ODF2_uc004bve.2_Missense_Mutation_p.S382C|uc004bvg.2_5'Flank	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	401	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						AGACAAAGAGAGCTTGAAGAA	0.567													5	16					0	0	0	0	T	131247076	T	T	131247076	3	4	245	1	0	0	0	0	1	0	0	0	10881	304	11	5	1298	5	ODF2	9	131247076	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	5916340	131247076	9966355	65	44999											
SNAPC4	6621	broad.mit.edu	37	chr9	139273385	139273385	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctgccaggagccagaaGtgccaggtttggctgccgcg	6	7	14	14	2	0	1	0	0	0	1	1	2	1	2	6	3	4	2	6	3	1	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr9:139273385G>A	uc004chh.2	-	21	2903	c.2894C>T	c.(2893-2895)ACT>ATT	p.T965I		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	965	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGAGCCAGAAGTGCCAGGTTT	0.667													14	23					0	0	0	0	A	139273385	A	A	139273385	3	1	245	1	0	0	0	0	1	0	0	0	14901	1029	36	4	1523	4	SNAPC4	9	139273385	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	8026309	139273385	1940046	66	45000											
MBL2	4153	broad.mit.edu	37	chr10	54528241	54528241	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcaggaagaacttgttccCaacttgtttgcccagagaga	11	10	11	9	0	1	3	1	0	0	3	2	5	2	4	2	2	3	2	2	2	3	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:54528241C>T	uc001jjt.2	-	4	468	c.403G>A	c.(403-405)GGG>AGG	p.G135R		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	135	C-type lectin.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						AACTTGTTCCCAACTTGTTTG	0.453													18	103					0	0	0	0	T	54528241	T	T	54528241	3	4	245	1	0	0	0	0	1	0	0	0	9403	594	21	4	347	4	MBL2	10	54528241	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08		54528241	81006506	67	45001											
MYST4	23522	broad.mit.edu	37	chr10	76788252	76788252	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtctcttcactaagacaatAtgaatgatgattcaagtaac	15	13	6	7	0	3	4	2	3	1	1	4	4	3	4	0	0	1	1	0	0	6	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:76788252A>G	uc001jwn.1	+	18	4163	c.3670A>G	c.(3670-3672)ATG>GTG	p.M1224V	MYST4_uc001jwo.1_Missense_Mutation_p.M932V|MYST4_uc001jwp.1_Missense_Mutation_p.M1041V	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1224					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					CTAAGACAATATGAATGATGA	0.373			T	CREBBP	AML								16	116					0	0	0	0	G	76788252	G	G	76788252	3	3	245	1	0	0	0	0	1	0	0	0	10158	449	16	5	3732	5	MYST4	10	76788252	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	22260011	76788252	58746495	68	45002											
DUPD1	338599	broad.mit.edu	37	chr10	76797686	76797686	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccagctcccggagctgctTcaaaaagccccggttcggga	8	7	12	14	3	1	0	1	0	0	0	4	2	3	2	4	3	4	4	4	3	2	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:76797686T>G	uc001jwq.1	-	3	571	c.571A>C	c.(571-573)AAG>CAG	p.K191Q		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	191	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CGGAGCTGCTTCAAAAAGCCC	0.642													19	65					0	0	0	0	G	76797686	G	G	76797686	3	3	245	1	0	0	0	0	1	0	0	0	4826	1792	62	5	95	5	DUPD1	10	76797686	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	9434	76797686	58737061	69	45003											
C10orf12	26148	broad.mit.edu	37	chr10	98742212	98742212	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acggaggagatgagtgtaccCcaggactgtcacctccttcc	9	8	11	13	1	1	2	1	1	0	1	3	5	3	4	5	3	1	1	5	3	1	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:98742212C>T	uc001kmv.2	+	1	1172	c.1065C>T	c.(1063-1065)CCC>CCT	p.P355P	C10orf12_uc009xvg.1_Silent_p.P665P	NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	355										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGAGTGTACCCCAGGACTGTC	0.522													37	80					0	0	0	0	T	98742212	T	T	98742212	2	4	245	1	0	0	0	0	0	0	0	1	1595	610	22	4		4	C10orf12	10	98742212	Silent	SNP	C	TCGA-CV-7263-01A-11D-2012-08	21944526	98742212	36792535	70	45004											
GFRA1	2674	broad.mit.edu	37	chr10	118030435	118030435	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agagcgacttctgcttcaggGcctccatggcgctgcggcac	6	8	13	14	3	2	1	1	0	1	1	3	2	3	1	2	3	3	3	2	3	0	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:118030435G>A	uc001lcj.2	-	3	931	c.233C>T	c.(232-234)GCC>GTC	p.A78V	GFRA1_uc001lci.2_Missense_Mutation_p.A78V|GFRA1_uc009xyr.2_Missense_Mutation_p.A78V	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	78	1.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTGCTTCAGGGCCTCCATGGC	0.602													13	34					0	0	0	0	A	118030435	A	A	118030435	3	1	245	1	0	0	0	0	1	0	0	0	6384	1203	42	4	1200	4	GFRA1	10	118030435	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	19288223	118030435	17504312	71	45005											
PDZD8	118987	broad.mit.edu	37	chr10	119043244	119043244	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaccctcttttctcactaaCtttattcctgtgctgtttcc	5	18	3	15	0	2	0	1	0	2	0	5	0	4	0	4	0	2	2	4	0	2	7			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:119043244C>A	uc001lde.1	-	5	3199	c.3000G>T	c.(2998-3000)AAG>AAT	p.K1000N		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	1000					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		TTCTCACTAACTTTATTCCTG	0.478													88	167					2.93434e-44	1.14338e-43	1	0	A	119043244	A	A	119043244	3	1	245	1	0	0	0	0	1	0	0	0	11759	564	20	4	468	4	PDZD8	10	119043244	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	1012809	119043244	16491503	72	45006											
GRK5	2869	broad.mit.edu	37	chr10	121212266	121212266	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatctggaccacacagacgaCgacttctactccaagttctc	12	9	6	14	2	3	1	0	0	3	1	5	4	4	2	2	1	1	1	2	1	3	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:121212266C>T	uc001led.2	+	14	1721	c.1488C>T	c.(1486-1488)GAC>GAT	p.D496D	GRK5_uc009xzh.2_Silent_p.D361D	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	496	AGC-kinase C-terminal.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		ACACAGACGACGACTTCTACT	0.597													9	25					0	0	0	0	T	121212266	T	T	121212266	2	4	245	1	0	0	0	0	0	0	0	1	6831	535	19	1		1	GRK5	10	121212266	Silent	SNP	C	TCGA-CV-7263-01A-11D-2012-08	2169022	121212266	14322481	73	45007											
MUC5B	727897	broad.mit.edu	37	chr11	1272638	1272638	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caccctgtcctccaccccagGgaccacctggatcctcacag	8	6	7	20	0	1	0	1	0	0	0	4	2	4	2	8	2	0	0	8	2	0	0			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:1272638G>A	uc009ycr.1	+	52	15620	c.15494G>A	c.(15493-15495)GGG>GAG	p.G5165E	MUC5B_uc001ltb.2_Missense_Mutation_p.G4846E	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4843	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCACCCCAGGGACCACCTGG	0.637													52	84					0	0	0	0	A	1272638	A	A	1272638	3	1	245	1	0	0	0	0	1	0	0	0	10032	1232	43	4	14659	4	MUC5B	11	1272638	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08		1272638	133733878	74	45008											
OR56B1	387748	broad.mit.edu	37	chr11	5757739	5757739	+	5'Flank	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatagagatttgaaattcatGttgaatcatgaatcatatgt	16	15	7	3	0	3	4	3	3	0	1	3	5	3	4	0	0	0	1	0	0	6	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:5757739G>T	uc001mbt.1	+						TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|OR56B1_uc001mbs.1_5'UTR|OR56B1_uc009yev.1_5'UTR	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		TGAAATTCATGTTGAATCATG	0.383													13	52					1.36491e-13	5.14116e-13	1	0	T	5757739	T	T	5757739	1	4	245	0	1	0	0	0	0	0	0	0	11191	1392	48	4		4	OR56B1	11	5757739	5'Flank	SNP	G	TCGA-CV-7263-01A-11D-2012-08	4485101	5757739	129248777	75	45009											
LGR4	55366	broad.mit.edu	37	chr11	27397864	27397864	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagaatccttagagatatcAggccttgaaaggtgccttcc	12	10	9	10	0	1	3	1	1	0	2	3	4	3	3	4	2	1	0	4	2	4	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d7331dbc-eaef-46db-be3f-7e6864aaaa82	g.chr11:27397864A>G	uc001mrj.3	-	13	1648	c.1163T>C	c.(1162-1164)CTG>CCG	p.L388P	LGR4_uc001mrk.3_Missense_Mutation_p.L364P	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	388	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						TAGAGATATCAGGCCTTGAAA	0.234													3	123					0	0	0	0	G	27397864	G	G	27397864	3	3	245	1	0	0	0	0	1	0	0	0	8797	188	7	5	1716	5	LGR4	11	27397864	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	21640125	27397864	107608652	76	45010											
SPRYD5	84767	broad.mit.edu	37	chr11	55653067	55653067	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttgctcagtgctctgaaTgcaagaagacaacgcggcag	11	9	11	10	2	3	3	1	1	2	2	3	3	3	3	0	1	4	4	0	1	4	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:55653067T>G	uc010rip.1	+	2	255	c.163T>G	c.(163-165)TGC>GGC	p.C55G	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	55	RING-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GTGCTCTGAATGCAAGAAGAC	0.507													7	38					0	0	0	0	G	55653067	G	G	55653067	3	3	245	1	0	0	0	0	1	0	0	0	15177	1464	51	5	165	5	SPRYD5	11	55653067	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	28255203	55653067	79353449	77	45011											
PYGM	5837	broad.mit.edu	37	chr11	64519456	64519456	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgtttatattcgtgaatccGcttcacctggatgtcgaaga	9	14	9	9	4	1	2	1	1	0	1	5	4	2	3	2	1	0	2	2	1	4	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:64519456G>A	uc001oax.3	-	14	2525	c.1708C>T	c.(1708-1710)CGG>TGG	p.R570W	PYGM_uc001oay.3_Missense_Mutation_p.R482W	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	570					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	TCGTGAATCCGCTTCACCTGG	0.512													15	81					0	0	0	0	A	64519456	A	A	64519456	3	1	245	1	0	0	0	0	1	0	0	0	12927	1086	38	1	848	1	PYGM	11	64519456	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	8866389	64519456	70487060	78	45012											
CLCF1	23529	broad.mit.edu	37	chr11	67134940	67134940	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatactcacataggtcccAgccaagctgcggagttggtg	9	9	13	10	1	1	0	1	0	0	0	2	2	2	2	2	4	4	2	2	4	3	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:67134940A>T	uc001okq.2	-	2	370	c.174T>A	c.(172-174)GCT>GCA	p.A58A	LOC100130987_uc010rpo.1_Intron|CLCF1_uc010rpp.1_Silent_p.A48A	NM_013246	NP_037378	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1 precursor	58					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity				0			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)			CATAGGTCCCAGCCAAGCTGC	0.577													38	68					0	0	0	0	T	67134940	T	T	67134940	2	4	245	1	0	0	0	0	0	0	0	1	3476	175	7	5		5	CLCF1	11	67134940	Silent	SNP	A	TCGA-CV-7263-01A-11D-2012-08	2615484	67134940	67871576	79	45013											
MMP20	9313	broad.mit.edu	37	chr11	102480739	102480739	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agagtcccccgaggcccatcGaatggataggaatccccgtg	10	6	12	13	3	0	1	0	0	0	1	3	5	2	3	5	3	0	0	5	3	3	1	rs148659857	byFrequency	TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:102480739G>A	uc001phc.2	-	4	559	c.546C>T	c.(544-546)TTC>TTT	p.F182F		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	182					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GAGGCCCATCGAATGGATAGG	0.498													8	40					0	0	0	0	A	102480739	A	A	102480739	2	1	245	1	0	0	0	0	0	0	0	1	9712	1049	37	1		1	MMP20	11	102480739	Silent	SNP	G	TCGA-CV-7263-01A-11D-2012-08	35345799	102480739	32525777	80	45014											
PCSK7	9159	broad.mit.edu	37	chr11	117095455	117095455	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccatccactgtcttcccatCgtcatctggtccccagctgt	5	12	7	17	1	3	0	1	0	2	0	7	0	6	0	5	1	1	1	5	1	0	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:117095455C>T	uc001pqr.2	-	7	1078	c.877G>A	c.(877-879)GAT>AAT	p.D293N		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	293	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		GTCTTCCCATCGTCATCTGGT	0.577			T	IGH@	MLCLS								50	191					0	0	0	0	T	117095455	T	T	117095455	3	4	245	1	0	0	0	0	1	0	0	0	11659	884	31	1	1524	1	PCSK7	11	117095455	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	14614716	117095455	17911061	81	45015											
DSCAML1	57453	broad.mit.edu	37	chr11	117303096	117303096	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccggatgtcagacatgtcGatgaggggtcctgtgctctg	6	10	16	9	2	2	2	1	1	1	1	4	4	3	3	2	4	1	1	2	4	0	0			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:117303096G>A	uc001prh.1	-	30	5333	c.5331C>T	c.(5329-5331)ATC>ATT	p.I1777I		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1717	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CAGACATGTCGATGAGGGGTC	0.572													6	42					0	0	0	0	A	117303096	A	A	117303096	2	1	245	1	0	0	0	0	0	0	0	1	4791	1048	37	1		1	DSCAML1	11	117303096	Silent	SNP	G	TCGA-CV-7263-01A-11D-2012-08	207641	117303096	17703420	82	45016											
TBCEL	219899	broad.mit.edu	37	chr11	120925792	120925792	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttcctgtgccttaatgacTatgaaacagtgtcttgtcct	8	16	7	10	0	2	2	0	2	2	0	4	2	4	2	3	0	2	0	3	0	3	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:120925792T>C	uc009zay.2	+	5	565	c.487T>C	c.(487-489)TAT>CAT	p.Y163H	TBCEL_uc001pxo.2_Missense_Mutation_p.Y163H|TBCEL_uc001pxp.2_Missense_Mutation_p.Y19H|TBCEL_uc001pxq.2_Intron	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	163	LRR 4.					cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		CCTTAATGACTATGAAACAGT	0.343													10	46					0	0	0	0	C	120925792	C	C	120925792	3	2	245	1	0	0	0	0	1	0	0	0	15701	1522	53	5	501	5	TBCEL	11	120925792	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	3622696	120925792	14080724	83	45017											
NRGN	4900	broad.mit.edu	37	chr11	124615418	124615418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagaacgcctgctccaagcCggacgacgacattctagaca	12	5	11	13	4	1	2	0	0	1	2	2	6	2	3	3	2	3	1	3	2	3	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:124615418C>T	uc001qaq.2	+	2	187	c.35C>T	c.(34-36)CCG>CTG	p.P12L	NRGN_uc001qar.2_Missense_Mutation_p.P12L	NM_006176	NP_006167	Q92686	NEUG_HUMAN	neurogranin	12					nervous system development|signal transduction		calmodulin binding				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		TGCTCCAAGCCGGACGACGAC	0.647													9	56					0	0	0	0	T	124615418	T	T	124615418	3	4	245	1	0	0	0	0	1	0	0	0	10705	652	23	1	41	1	NRGN	11	124615418	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	3689626	124615418	10391098	84	45018											
MGP	4256	broad.mit.edu	37	chr12	15035958	15035958	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggggatatgaaggtatttgCatttctcctgttaatgaagg	11	14	12	4	0	1	2	0	2	1	0	2	3	1	3	1	4	1	3	1	4	5	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:15035958C>T	uc001rcn.1	-	3	221	c.118G>A	c.(118-120)GCA>ACA	p.A40T		NM_000900	NP_000891	P08493	MGP_HUMAN	matrix Gla protein precursor	40					cartilage condensation|cell differentiation|ossification|regulation of bone mineralization	proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent|structural constituent of bone			ovary(1)	1						AAGGTATTTGCATTTCTCCTG	0.383													11	32					0	0	0	0	T	15035958	T	T	15035958	3	4	245	1	0	0	0	0	1	0	0	0	9611	710	25	4	201	4	MGP	12	15035958	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08		15035958	118815937	85	45019											
PDE3A	5139	broad.mit.edu	37	chr12	20782996	20782996	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctaggttctcacagggccttAacttacactcagagtgcccc	9	10	8	14	0	2	1	2	0	1	1	3	1	2	1	3	2	3	1	3	2	3	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:20782996A>T	uc001reh.1	+	6	1717	c.1695A>T	c.(1693-1695)TTA>TTT	p.L565F		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	565					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	ACAGGGCCTTAACTTACACTC	0.453													77	121					0	0	0	0	T	20782996	T	T	20782996	3	4	245	1	0	0	0	0	1	0	0	0	11691	359	13	5	1717	5	PDE3A	12	20782996	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	5747038	20782996	113068899	86	45020											
NUP107	57122	broad.mit.edu	37	chr12	69083344	69083344	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagatgaaaattttggtaaTactacaccaagaaaccaggt	18	9	7	7	0	0	3	0	1	0	2	0	3	0	3	2	2	3	1	2	2	8	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:69083344T>C	uc001suf.2	+	3	247	c.132T>C	c.(130-132)AAT>AAC	p.N44N	uc001sud.1_5'Flank|uc001sue.1_5'Flank|NUP107_uc001sug.2_5'UTR|NUP107_uc010stj.1_Missense_Mutation_p.I6T	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	44					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			ATTTTGGTAATACTACACCAA	0.328													16	48					0	0	0	0	C	69083344	C	C	69083344	2	2	245	1	0	0	0	0	0	0	0	1	10807	1403	49	5		5	NUP107	12	69083344	Silent	SNP	T	TCGA-CV-7263-01A-11D-2012-08	48300348	69083344	64768551	87	45021											
ANO4	121601	broad.mit.edu	37	chr12	101295618	101295618	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaccaaagtcttccacccaGgtgatgcatggggaagttca	13	8	10	10	0	2	1	1	1	1	0	3	2	3	2	3	3	2	2	3	3	3	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:101295618G>A	uc010svm.1	+	2	627	c.55G>A	c.(55-57)GAA>AAA	p.E19K	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.V19M|ANO4_uc001thx.2_Missense_Mutation_p.E19K	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	19	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						CTTCCACCCAGGTGATGCATG	0.443										HNSCC(74;0.22)			29	69					0	0	0	0	A	101295618	A	A	101295618	3	1	245	1	0	0	0	0	1	0	0	0	699	1014	35	4	57	4	ANO4	12	101295618	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	32212274	101295618	32556277	88	45022											
PTPN11	5781	broad.mit.edu	37	chr12	112940025	112940025	+	Silent	SNP	T	C	C																															acgagtggagatcagagcccTctcccgccttgtactccaac																										TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:112940025T>C	uc001ttx.2	+	14	2057	c.1677T>C	c.(1675-1677)CCT>CCC	p.P559P		NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	563					axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						ATCAGAGCCCTCTCCCGCCTT	0.423			Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				5	162					0	0	0	0	C	112940025	C	C	112940025	2	2	245	1	0	0	0	0	0	0	0	1	12843	1538	54	5		5	PTPN11	12	112940025	Silent	SNP	T	TCGA-CV-7263-01A-11D-2012-08	11644407	112940025	20911870	89	45023	96	2									
PTPN11	5781	broad.mit.edu	37	chr12	112940027	112940027	+	Missense_Mutation	SNP	T	C	C																															gagtggagatcagagccctcTcccgccttgtactccaacgc																										TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:112940027T>C	uc001ttx.2	+	14	2059	c.1679T>C	c.(1678-1680)CTC>CCC	p.L560P		NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	564			L -> F (in NS1).		axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						CAGAGCCCTCTCCCGCCTTGT	0.423			Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				5	164					0	0	0	0	C	112940027	C	C	112940027	3	2	245	1	0	0	0	0	1	0	0	0	12843	1551	54	5	1733	5	PTPN11	12	112940027	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	2	112940027	20911868	90	45024	96	2									
DTX1	1840	broad.mit.edu	37	chr12	113496166	113496166	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgtgctgaaggaggacgctCgcggttccgtggtcctgggg	5	8	18	10	5	0	1	0	1	0	0	3	3	2	3	2	6	1	3	2	6	1	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:113496166C>T	uc001tuk.1	+	1	505	c.169C>T	c.(169-171)CGC>TGC	p.R57C		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	57	WWE 1.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						GGAGGACGCTCGCGGTTCCGT	0.642													26	101					0	0	0	0	T	113496166	T	T	113496166	3	4	245	1	0	0	0	0	1	0	0	0	4815	884	31	1	171	1	DTX1	12	113496166	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	556139	113496166	20355729	91	45025											
SYNE2	23224	broad.mit.edu	37	chr14	64522880	64522880	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaactgggaatgatatcCagccccgaagccaaactaca	16	5	9	11	1	0	2	0	1	0	1	1	5	1	3	4	1	5	0	4	1	6	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr14:64522880C>T	uc001xgm.2	+	49	10193	c.9963C>T	c.(9961-9963)TCC>TCT	p.S3321S	SYNE2_uc001xgl.2_Silent_p.S3321S|SYNE2_uc010apw.1_Silent_p.S27S	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3321	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAATGATATCCAGCCCCGAAG	0.433													8	31					0	0	0	0	T	64522880	T	T	64522880	2	4	245	1	0	0	0	0	0	0	0	1	15512	581	21	4		4	SYNE2	14	64522880	Silent	SNP	C	TCGA-CV-7263-01A-11D-2012-08		64522880	42826660	92	45026											
TJP1	7082	broad.mit.edu	37	chr15	30008972	30008972	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataatattcttcatcttcttCagggtcataatgattggacc	11	16	6	8	0	6	1	3	1	3	0	6	2	6	2	1	2	0	0	1	2	3	8			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr15:30008972C>T	uc001zcr.2	-	23	4520	c.4045G>A	c.(4045-4047)GAA>AAA	p.E1349K	TJP1_uc010azl.2_Missense_Mutation_p.E1337K|TJP1_uc001zcq.2_Missense_Mutation_p.E1273K|TJP1_uc001zcs.2_Missense_Mutation_p.E1269K	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1349					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TCATCTTCTTCAGGGTCATAA	0.428													9	46					0	0	0	0	T	30008972	T	T	30008972	3	4	245	1	0	0	0	0	1	0	0	0	15995	835	29	2	1225	2	TJP1	15	30008972	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08		30008972	72522420	93	45027											
UBR1	197131	broad.mit.edu	37	chr15	43360173	43360173	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttgtaggctgtatatgaCgtggtcatatgaatggtgtt	8	17	12	4	1	2	2	1	2	1	0	2	2	2	2	0	3	0	4	0	3	5	6			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr15:43360173C>T	uc001zqq.2	-	6	787	c.721G>A	c.(721-723)GTC>ATC	p.V241I	UBR1_uc010udk.1_Missense_Mutation_p.V241I	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	241					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		CTGTATATGACGTGGTCATAT	0.383													11	83					0	0	0	0	T	43360173	T	T	43360173	3	4	245	1	0	0	0	0	1	0	0	0	16969	536	19	1	4696	1	UBR1	15	43360173	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	13351201	43360173	59171219	94	45028											
NHLRC4	283948	broad.mit.edu	37	chr16	618123	618123	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgtgagtgaggagtttgggGatgtgaggctgtttggcagt	6	13	19	3	0	0	3	0	3	0	0	0	5	0	5	0	5	0	4	0	5	0	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr16:618123G>A	uc002chl.2	+	2	672	c.76G>A	c.(76-78)GAT>AAT	p.D26N	PIGQ_uc010bqw.2_Intron|PIGQ_uc002chm.2_5'Flank|PIGQ_uc002chn.2_5'Flank|PIGQ_uc002cho.2_5'Flank	NM_176677	NP_788850	P0CG21	NHLC4_HUMAN	hypothetical protein LOC283948	26											0						GGAGTTTGGGGATGTGAGGCT	0.687													6	14					0	0	0	0	A	618123	A	A	618123	3	1	245	1	0	0	0	0	1	0	0	0	10462	1174	41	2	78	2	NHLRC4	16	618123	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08		618123	89736630	95	45029											
SMG1	23049	broad.mit.edu	37	chr16	18828771	18828771	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaactttcaaaatgaatgaTattgctgcagagaaatgtga	17	12	8	4	0	1	4	1	3	0	1	1	5	1	4	0	0	3	2	0	0	7	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr16:18828771T>C	uc002dfm.2	-	57	10279	c.9916A>G	c.(9916-9918)ATC>GTC	p.I3306V	SMG1_uc010bwb.2_Missense_Mutation_p.I3166V|SMG1_uc010bwa.2_Missense_Mutation_p.I2037V	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3306					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						AAATGAATGATATTGCTGCAG	0.413													2	8					0	0	0	0	C	18828771	C	C	18828771	3	2	245	1	0	0	0	0	1	0	0	0	14859	1406	49	5	1097	5	SMG1	16	18828771	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	18210648	18828771	71525982	96	45030											
PLK1	5347	broad.mit.edu	37	chr16	23690194	23690195	+	5'Flank	INS	-	GGAGC	GGAGC																															gccgcgtttgaattcggggaINSggagcggagcggtgcggagg																										TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d7331dbc-eaef-46db-be3f-7e6864aaaa82	g.chr16:23690194_23690195insGGAGC	uc002dlz.1	+							NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		GAATTCGGGGAGGAGCGGAGCG	0.653													---	---	---								GGAGC	23690195	GGAGC	GGAGC	23690194	6	5	245	0	1	1	1	0	0	0	0	0	12149	319	11	0		0	PLK1	16	23690194	5'Flank	INS	-	TCGA-CV-7263-01A-11D-2012-08	4861423	23690194	66664559	97	45031											
GTF3C1	2975	broad.mit.edu	37	chr16	27544670	27544670	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtccgtgtgctcagcatgAccgaaagcttctccatgagg	9	10	11	11	2	2	2	1	2	1	0	4	3	3	2	3	1	3	3	3	1	2	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr16:27544670A>T	uc002dov.1	-	5	831	c.791T>A	c.(790-792)GTC>GAC	p.V264D	GTF3C1_uc002dou.2_Missense_Mutation_p.V264D	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	264						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GCTCAGCATGACCGAAAGCTT	0.522													21	54					0	0	0	0	T	27544670	T	T	27544670	3	4	245	1	0	0	0	0	1	0	0	0	6911	275	10	5	5670	5	GTF3C1	16	27544670	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	3854476	27544670	62810083	98	45032											
P2RX1	5023	broad.mit.edu	37	chr17	3819557	3819557	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaactgagccccctgcaCggcctctgctctcagggtga	7	8	11	15	1	3	3	2	2	2	1	4	3	3	3	3	2	4	2	3	2	1	0			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:3819557C>T	uc002fww.2	-	1	404	c.-37G>A	c.(-39--35)CCGTG>CCATG		P2RX1_uc010ckm.1_Translation_Start_Site	NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1						platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		GCCCCCTGCACGGCCTCTGCT	0.677													17	40					0	0	0	0	T	3819557	T	T	3819557	1	4	245	1	0	0	0	0	0	0	0	0	11393	551	19	1		1	P2RX1	17	3819557	Translation_Start_Site	SNP	C	TCGA-CV-7263-01A-11D-2012-08		3819557	77375653	99	45033											
NUP88	4927	broad.mit.edu	37	chr17	5290067	5290067	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaatgcactttcgctggtagGcactgagaataatggtgggt	10	11	14	6	1	0	1	0	1	0	1	1	3	0	1	0	4	1	4	0	4	4	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:5290067G>A	uc002gbo.1	-	16	2149	c.2123C>T	c.(2122-2124)GCC>GTC	p.A708V	NUP88_uc002gbn.2_5'Flank|NUP88_uc010vsx.1_Missense_Mutation_p.A724V	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	708					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						TCGCTGGTAGGCACTGAGAAT	0.368													32	46					0	0	0	0	A	5290067	A	A	5290067	3	1	245	1	0	0	0	0	1	0	0	0	10825	1203	42	4	110	4	NUP88	17	5290067	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	1470510	5290067	75905143	100	45034											
TP53	7157	broad.mit.edu	37	chr17	7579378	7579378	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cggaaaccgtagctgccctgGtaggttttctgggaagggac	8	9	15	9	2	1	0	0	0	1	0	1	3	1	3	2	5	3	4	2	5	4	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:7579378G>C	uc002gim.2	-	4	503	c.309C>G	c.(307-309)TAC>TAG	p.Y103*	TP53_uc002gig.1_Nonsense_Mutation_p.Y103*|TP53_uc002gih.2_Nonsense_Mutation_p.Y103*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.Y103*|TP53_uc010cni.1_Nonsense_Mutation_p.Y103*|TP53_uc002gij.2_Nonsense_Mutation_p.Y103*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.Y64*|TP53_uc010cnk.1_Nonsense_Mutation_p.Y118*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	103	Interaction with HIPK1 (By similarity).||Interaction with WWOX.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G59fs*23(3)|p.Y103*(2)|p.V73fs*9(1)|p.Y103Y(1)|p.Y103_Q104>**(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y103_L111>L(1)|p.Y103fs*15(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGCTGCCCTGGTAGGTTTTCT	0.637		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	46					0	0	0	0	C	7579378	C	C	7579378	4	2	245	1	0	0	0	0	0	1	0	0	16448	1256	44	4	993	4	TP53	17	7579378	Nonsense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	2289311	7579378	73615832	101	45035											
CHD3	1107	broad.mit.edu	37	chr17	7802768	7802768	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctatgtggtgacatacacGggtgacaaggacagccgggc	10	8	14	9	2	1	2	0	2	1	0	1	3	1	3	1	4	2	0	1	4	3	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:7802768G>A	uc002gje.2	+	15	2601	c.2451G>A	c.(2449-2451)ACG>ACA	p.T817T	CHD3_uc002gjd.2_Silent_p.T876T|CHD3_uc002gjf.2_Silent_p.T817T	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	817	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TGACATACACGGGTGACAAGG	0.498													43	78					0	0	0	0	A	7802768	A	A	7802768	2	1	245	1	0	0	0	0	0	0	0	1	3341	1103	39	1		1	CHD3	17	7802768	Silent	SNP	G	TCGA-CV-7263-01A-11D-2012-08	223390	7802768	73392442	102	45036											
MYH10	4628	broad.mit.edu	37	chr17	8398540	8398540	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgcttcttccagaagggtgGagacattatctagctcattc	9	13	9	10	0	3	2	1	0	2	2	5	3	4	2	1	2	2	2	1	2	3	5			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:8398540G>A	uc002gll.2	-	29	3974	c.3878C>T	c.(3877-3879)TCC>TTC	p.S1293F	MYH10_uc002glm.2_Missense_Mutation_p.S1324F|MYH10_uc010cnx.2_Missense_Mutation_p.S1302F	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1293	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CAGAAGGGTGGAGACATTATC	0.413													11	22					0	0	0	0	A	8398540	A	A	8398540	3	1	245	1	0	0	0	0	1	0	0	0	10083	1174	41	2	2104	2	MYH10	17	8398540	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	595772	8398540	72796670	103	45037											
GAS2L2	246176	broad.mit.edu	37	chr17	34077293	34077293	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacagcaccacgttcttcaCgttcttgcgcagcaccaagt	10	9	7	15	3	3	0	1	0	2	0	3	0	3	0	2	0	3	5	2	0	1	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:34077293C>A	uc002hjv.1	-	2	458	c.430G>T	c.(430-432)GTG>TTG	p.V144L		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	144	CH.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACGTTCTTCACGTTCTTGCGC	0.642													34	235					6.29468e-14	2.38691e-13	1	0	A	34077293	A	A	34077293	3	1	245	1	0	0	0	0	1	0	0	0	6282	536	19	3	2232	3	GAS2L2	17	34077293	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	25678753	34077293	47117917	104	45038											
KRT39	390792	broad.mit.edu	37	chr17	39118751	39118751	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacctggtttaggtcagcaGaaggggcagcagtcacttca	11	8	13	9	0	3	1	3	0	0	1	3	2	3	1	1	4	3	4	1	4	3	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:39118751G>A	uc002hvo.1	-	4	809	c.773C>T	c.(772-774)TCT>TTT	p.S258F	KRT39_uc010wfm.1_5'UTR	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	258	Linker 12.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				TAGGTCAGCAGAAGGGGCAGC	0.448													129	256					0	0	0	0	A	39118751	A	A	39118751	3	1	245	1	0	0	0	0	1	0	0	0	8515	942	33	2	718	2	KRT39	17	39118751	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	5041458	39118751	42076459	105	45039											
STAT5B	6777	broad.mit.edu	37	chr17	40359689	40359689	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctcccaagcggtcggctaggGaccgaatggagaagtctctg	9	7	14	11	3	1	1	0	0	1	1	4	4	2	2	2	4	1	1	2	4	4	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:40359689G>T	uc002hzh.2	-	16	2133	c.1964C>A	c.(1963-1965)TCC>TAC	p.S655Y		NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	655	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GTCGGCTAGGGACCGAATGGA	0.418													13	46					7.03913e-09	2.58254e-08	1	0	T	40359689	T	T	40359689	3	4	245	1	0	0	0	0	1	0	0	0	15335	1174	41	2	415	2	STAT5B	17	40359689	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	1240938	40359689	40835521	106	45040											
TUBD1	51174	broad.mit.edu	37	chr17	57951968	57951968	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggccagcccaagtaaatGtggtgtatgccaatgaattc	12	9	12	8	0	0	1	0	1	0	0	1	2	0	2	3	3	2	2	3	3	6	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:57951968G>A	uc002ixw.1	-	6	1144	c.866C>T	c.(865-867)ACA>ATA	p.T289I	TUBD1_uc010ddf.1_Intron|TUBD1_uc010ddg.1_Missense_Mutation_p.T254I|TUBD1_uc010ddh.1_Intron|TUBD1_uc010wok.1_Missense_Mutation_p.T289I|TUBD1_uc002ixx.1_Intron|TUBD1_uc010wol.1_Missense_Mutation_p.T73I|TUBD1_uc010ddi.1_Intron	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	289					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			CCAAGTAAATGTGGTGTATGC	0.423													31	218					0	0	0	0	A	57951968	A	A	57951968	3	1	245	1	0	0	0	0	1	0	0	0	16830	1377	48	4	511	4	TUBD1	17	57951968	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	17592279	57951968	23243242	107	45041											
SOX9	6662	broad.mit.edu	37	chr17	70120341	70120341	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctacaccgaccaccagaactCcagctcctactacagccacg	12	5	5	19	2	0	1	0	0	0	1	2	2	2	1	6	0	6	1	6	0	4	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:70120341C>T	uc002jiw.2	+	3	1715	c.1343C>T	c.(1342-1344)TCC>TTC	p.S448F		NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	448					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CACCAGAACTCCAGCTCCTAC	0.637													21	151					0	0	0	0	T	70120341	T	T	70120341	3	4	245	1	0	0	0	0	1	0	0	0	15022	855	30	2	1353	2	SOX9	17	70120341	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	12168373	70120341	11074869	108	45042											
CD300E	342510	broad.mit.edu	37	chr17	72608823	72608823	+	Frame_Shift_Del	DEL	T	-	-																															gaggagcccactgaggcctgTtcacccagaagacagcaccc																										TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:72608823delT	uc002jlb.1	-	4	628	c.587delA	c.(586-588)AACfs	p.N196fs		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	196	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						CTGAGGCCTGTTCACCCAGAA	0.632													---	---	---								-	72608823	-	-	72608823	7	5	245	1	0	1	0	1	0	0	0	0	3013	1725	60	0	34	0	CD300E	17	72608823	Frame_Shift_Del	DEL	T	TCGA-CV-7263-01A-11D-2012-08	2488482	72608823	8586387	109	45043											
ENOSF1	55556	broad.mit.edu	37	chr18	683302	683302	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggttggctcctcaatccAcaatggcttgaacttggcca	9	10	11	11	0	1	1	1	1	0	0	3	2	3	2	3	5	1	3	3	5	3	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr18:683302A>C	uc002kku.3	-	11	895	c.820T>G	c.(820-822)TGG>GGG	p.W274G	ENOSF1_uc002kkt.3_Missense_Mutation_p.W192G|ENOSF1_uc010dke.2_RNA|ENOSF1_uc010dkf.2_Missense_Mutation_p.W295G|ENOSF1_uc002kkv.3_Missense_Mutation_p.W261G|ENOSF1_uc002kkw.3_Missense_Mutation_p.W93G|ENOSF1_uc002kkx.3_Missense_Mutation_p.W198G	NM_017512	NP_059982	Q7L5Y1	ENOF1_HUMAN	enolase superfamily 1 isoform rTS beta	274					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			ovary(1)	1						TCCTCAATCCACAATGGCTTG	0.532													35	73					0	0	0	0	C	683302	C	C	683302	3	2	245	1	0	0	0	0	1	0	0	0	5149	159	6	5	535	5	ENOSF1	18	683302	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08		683302	77393946	110	45044											
LAMA1	284217	broad.mit.edu	37	chr18	6956637	6956637	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaaggaagccgctcctactgGaaaagcccggggctctggca	11	5	13	12	2	1	0	0	0	1	0	2	2	2	2	3	5	3	3	3	5	5	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr18:6956637G>A	uc002knm.2	-	56	8186	c.8092C>T	c.(8092-8094)CCA>TCA	p.P2698S	LAMA1_uc002knk.2_5'Flank|LAMA1_uc002knl.2_Missense_Mutation_p.P151S|LAMA1_uc010wzj.1_Missense_Mutation_p.P2174S	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2698					axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTCCTACTGGAAAAGCCCGG	0.572													13	77					0	0	0	0	A	6956637	A	A	6956637	3	1	245	1	0	0	0	0	1	0	0	0	8645	1174	41	2	1167	2	LAMA1	18	6956637	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	6273335	6956637	71120611	111	45045											
VPS4B	9525	broad.mit.edu	37	chr18	61074674	61074674	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctaaagcaaccttgaagttGattctgtagtttcttttttt	9	20	6	6	0	3	2	0	2	3	0	3	2	3	2	1	0	2	4	1	0	5	9			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr18:61074674G>A	uc002lix.2	-	4	615	c.355C>T	c.(355-357)CAA>TAA	p.Q119*	VPS4B_uc010dpx.2_Nonsense_Mutation_p.Q119*|VPS4B_uc010dpy.2_Intron|VPS4B_uc010dpz.1_Intron	NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B	119					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1						CCTTGAAGTTGATTCTGTAGT	0.289													5	14					0	0	0	0	A	61074674	A	A	61074674	4	1	245	1	0	0	0	0	0	1	0	0	17281	1299	45	2	1011	2	VPS4B	18	61074674	Nonsense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	54118037	61074674	17002574	112	45046											
RTTN	25914	broad.mit.edu	37	chr18	67687941	67687941	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgtggtgttctccagtggCatctgggaagccaactttag	8	11	12	10	1	2	0	0	0	2	0	3	1	2	1	3	3	2	2	3	3	3	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr18:67687941C>T	uc002lkp.2	-	45	6131	c.6063G>A	c.(6061-6063)ATG>ATA	p.M2021I	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.M1109I|RTTN_uc002lkn.2_Missense_Mutation_p.M11I|RTTN_uc010dqp.2_Missense_Mutation_p.M273I	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	2021							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				TCTCCAGTGGCATCTGGGAAG	0.468													19	115					0	0	0	0	T	67687941	T	T	67687941	3	4	245	1	0	0	0	0	1	0	0	0	13802	710	25	4	637	4	RTTN	18	67687941	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	6613267	67687941	10389307	113	45047											
EVI5L	115704	broad.mit.edu	37	chr19	7916351	7916351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agacctcaacacccacttccGttcccaaagcttccacacat	12	8	3	18	1	1	1	1	0	0	1	4	1	4	1	5	0	2	2	5	0	2	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr19:7916351G>A	uc002min.2	+	7	939	c.785G>A	c.(784-786)CGT>CAT	p.R262H	EVI5L_uc010xjz.1_Missense_Mutation_p.R262H|EVI5L_uc002mio.1_5'UTR	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	262	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						ACCCACTTCCGTTCCCAAAGC	0.637													39	81					0	0	0	0	A	7916351	A	A	7916351	3	1	245	1	0	0	0	0	1	0	0	0	5314	1145	40	1	807	1	EVI5L	19	7916351	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08		7916351	51212632	114	45048											
GIPC1	10755	broad.mit.edu	37	chr19	14593541	14593541	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggcctcggcgatcttgccaTacagctccttgacgttggtg	6	11	12	12	3	1	1	0	1	1	0	3	2	2	1	3	3	3	2	3	3	1	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr19:14593541T>C	uc002myt.2	-	4	518	c.248A>G	c.(247-249)TAT>TGT	p.Y83C	GIPC1_uc002myu.2_Missense_Mutation_p.Y83C|GIPC1_uc002myv.2_Intron|GIPC1_uc002myw.2_Intron|GIPC1_uc002myx.2_Missense_Mutation_p.Y83C|GIPC1_uc002myy.2_Intron	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	83					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0						GATCTTGCCATACAGCTCCTT	0.682													8	26					0	0	0	0	C	14593541	C	C	14593541	3	2	245	1	0	0	0	0	1	0	0	0	6429	1406	49	5	777	5	GIPC1	19	14593541	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	6677190	14593541	44535442	115	45049											
ZNF331	55422	broad.mit.edu	37	chr19	54080198	54080198	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcagagacatcataaggaGaattcctttgaatgtaagga	16	10	9	6	0	2	3	2	1	0	2	3	6	3	4	1	2	0	1	1	2	4	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr19:54080198G>A	uc002qbx.1	+	7	1818	c.384G>A	c.(382-384)GAG>GAA	p.E128E	ZNF331_uc002qby.1_Silent_p.E128E|ZNF331_uc002qbz.1_Silent_p.E128E|ZNF331_uc002qca.1_Silent_p.E128E|ZNF331_uc010eqr.1_Silent_p.E128E|ZNF331_uc002qcb.1_Silent_p.E128E|ZNF331_uc002qcc.1_Silent_p.E128E|ZNF331_uc002qcd.1_Silent_p.E128E	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		ATCATAAGGAGAATTCCTTTG	0.418			T	?	follicular thyroid adenoma								41	90					0	0	0	0	A	54080198	A	A	54080198	2	1	245	1	0	0	0	0	0	0	0	1	17916	933	33	2		2	ZNF331	19	54080198	Silent	SNP	G	TCGA-CV-7263-01A-11D-2012-08	39486657	54080198	5048785	116	45050											
BRSK1	84446	broad.mit.edu	37	chr19	55795213	55795214	+	5'Flank	DEL	CT	-	-																															tctgccccatctgttgggtcCtctctctctctctccatcct																										TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d7331dbc-eaef-46db-be3f-7e6864aaaa82	g.chr19:55795213_55795214delCT	uc002qkg.2	+						BRSK1_uc002qkf.2_Intron	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1						establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		ctgttgggtcctctctctctct	0													---	---	---								-	55795214	-	-	55795213	6	5	245	0	1	1	0	1	0	0	0	0	1528	696	24	0		0	BRSK1	19	55795213	5'Flank	DEL	CT	TCGA-CV-7263-01A-11D-2012-08	1715015	55795213	3333770	117	45051											
C20orf54	113278	broad.mit.edu	37	chr20	744241	744241	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctggcccataggacaggcagGagtaggtctgcacagagggc	10	5	16	10	0	1	1	0	0	1	1	1	3	1	3	1	6	1	3	1	6	2	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr20:744241G>A	uc002wed.3	-	3	1313	c.974C>T	c.(973-975)TCC>TTC	p.S325F	C20orf54_uc002wee.2_Missense_Mutation_p.S325F	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	325					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						GGACAGGCAGGAGTAGGTCTG	0.627													22	118					0	0	0	0	A	744241	A	A	744241	3	1	245	1	0	0	0	0	1	0	0	0	2124	1174	41	2	447	2	C20orf54	20	744241	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08		744241	62281279	118	45052											
BMP2	650	broad.mit.edu	37	chr20	6759194	6759194	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccgctgtgatgcggtggActgcacagggacacgccaac	8	5	13	15	3	0	1	0	1	0	0	0	3	0	3	3	3	3	2	3	3	1	0			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr20:6759194A>G	uc002wmu.1	+	3	1434	c.649A>G	c.(649-651)ACT>GCT	p.T217A		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	217					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	GATGCGGTGGACTGCACAGGG	0.522													4	49					0	0	0	0	G	6759194	G	G	6759194	3	3	245	1	0	0	0	0	1	0	0	0	1462	275	10	5	655	5	BMP2	20	6759194	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	6014953	6759194	56266326	119	45053											
C20orf118	140711	broad.mit.edu	37	chr20	35515884	35515884	+	Frame_Shift_Del	DEL	T	-	-																															aagtggactggaagcaactcTttctttgtgaagggagactt																										TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr20:35515884delT	uc002xgg.1	+	5	473	c.465delT	c.(463-465)TCTfs	p.S155fs		NM_080628	NP_542195	A0PJX2	CT118_HUMAN	hypothetical protein LOC140711	155	TLD.										0		Myeloproliferative disorder(115;0.00874)				GAAGCAACTCTTTCTTTGTGA	0.532											OREG0025911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	35515884	-	-	35515884	7	5	245	1	0	1	0	1	0	0	0	0	2094	1596	56	0	483	0	C20orf118	20	35515884	Frame_Shift_Del	DEL	T	TCGA-CV-7263-01A-11D-2012-08	28756690	35515884	27509636	120	45054											
RIMS4	140730	broad.mit.edu	37	chr20	43385559	43385559	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctggaggactttgccctgggGactctcaggaaacagcagca	10	7	13	11	0	1	0	1	0	1	0	2	4	1	4	1	5	4	2	1	5	1	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr20:43385559G>A	uc002xms.2	-	5	571	c.571C>T	c.(571-573)CCC>TCC	p.P191S	RIMS4_uc010ggu.2_Missense_Mutation_p.P192S	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	191	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				TTGCCCTGGGGACTCTCAGGA	0.567													139	217					0	0	0	0	A	43385559	A	A	43385559	3	1	245	1	0	0	0	0	1	0	0	0	13435	1174	41	2	246	2	RIMS4	20	43385559	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08	7869675	43385559	19639961	121	45055											
SFRS15	57466	broad.mit.edu	37	chr21	33060638	33060639	+	Frame_Shift_Ins	INS	-	A	A																															cctgtggaggtggcactgttINSataggtgcaggaacaggaat																										TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr21:33060638_33060639insA	uc002ypd.2	-	16	2450_2451	c.2024_2025insT	c.(2023-2025)ATAfs	p.I675fs	SFRS15_uc002ype.2_Frame_Shift_Ins_p.I675fs|SFRS15_uc010glu.2_Frame_Shift_Ins_p.I660fs|SFRS15_uc002ypf.1_Frame_Shift_Ins_p.I349fs	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	675						nucleus	nucleotide binding|RNA binding				0						GTGGCACTGTTATAGGTGCAGG	0.441													---	---	---								A	33060639	A	A	33060638	7	5	245	1	0	1	1	0	0	0	0	0	14236	1744	61	0	1438	0	SFRS15	21	33060638	Frame_Shift_Ins	INS	-	TCGA-CV-7263-01A-11D-2012-08		33060638	15069257	122	45056											
ZDHHC8	29801	broad.mit.edu	37	chr22	20127348	20127348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcacacatggtgggcgtcGtggccttcggcctggtctac	4	10	15	12	3	1	0	0	0	1	0	3	0	1	0	2	5	2	1	2	5	1	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr22:20127348G>A	uc002zrq.2	+	4	596	c.490G>A	c.(490-492)GTG>ATG	p.V164M	ZDHHC8_uc002zrr.1_Missense_Mutation_p.V164M|ZDHHC8_uc010gsa.2_Intron	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	164	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					GGTGGGCGTCGTGGCCTTCGG	0.602													8	60					0	0	0	0	A	20127348	A	A	20127348	3	1	245	1	0	0	0	0	1	0	0	0	17688	1145	40	1	504	1	ZDHHC8	22	20127348	Missense_Mutation	SNP	G	TCGA-CV-7263-01A-11D-2012-08		20127348	31177218	123	45057											
PIK3IP1	113791	broad.mit.edu	37	chr22	31688261	31688261	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaaagattgtaatctcacCtccagatccataggcttctg	12	11	8	10	0	2	2	1	0	2	2	5	3	4	3	3	2	0	2	3	2	3	4			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr22:31688261C>T	uc003akm.2	-	1	260	c.70G>A	c.(70-72)GGC>AGC	p.G24S	PIK3IP1_uc003akl.2_5'Flank|PIK3IP1_uc011alo.1_Missense_Mutation_p.G24S|PIK3IP1_uc003akn.2_Silent_p.E4E|PIK3IP1_uc003ako.2_Missense_Mutation_p.G24S	NM_052880	NP_443112	Q96FE7	P3IP1_HUMAN	HGFL protein isoform 1	24	Extracellular (Potential).|Kringle.					integral to membrane				ovary(1)	1						GTAATCTCACCTCCAGATCCA	0.502											OREG0026478	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	56					0	0	0	0	T	31688261	T	T	31688261	3	4	245	1	0	0	0	0	1	0	0	0	11972	695	24	4	745	4	PIK3IP1	22	31688261	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	11560913	31688261	19616305	124	45058											
C22orf42	150297	broad.mit.edu	37	chr22	32545757	32545757	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacagaggtaatcttcatatCtctcctttgcctgcaatagg	10	14	7	10	0	3	1	1	0	2	1	5	1	4	1	2	2	3	2	2	2	5	6			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr22:32545757C>T	uc003amd.2	-	8	706	c.665G>A	c.(664-666)AGA>AAA	p.R222K		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	222										ovary(1)|skin(1)	2						ATCTTCATATCTCTCCTTTGC	0.279													9	48					0	0	0	0	T	32545757	T	T	32545757	3	4	245	1	0	0	0	0	1	0	0	0	2159	913	32	2	98	2	C22orf42	22	32545757	Missense_Mutation	SNP	C	TCGA-CV-7263-01A-11D-2012-08	857496	32545757	18758809	125	45059											
SELO	83642	broad.mit.edu	37	chr22	50654274	50654274	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggaggagctgaggctggccTtccggccccagatggatccc	6	7	15	13	1	0	2	0	1	0	1	2	5	2	5	5	6	1	2	5	6	0	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr22:50654274T>C	uc011arr.1	+	6	1538	c.1480T>C	c.(1480-1482)TTC>CTC	p.F494L	SELO_uc010hap.2_Missense_Mutation_p.F305L|SELO_uc003bjy.2_Missense_Mutation_p.F174L|SELO_uc003bjz.2_Missense_Mutation_p.L246P	NM_031454	NP_113642	Q9BVL4	SELO_HUMAN	selenoprotein O	494											0		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		GAGGCTGGCCTTCCGGCCCCA	0.582													19	58					0	0	0	0	C	50654274	C	C	50654274	3	2	245	1	0	0	0	0	1	0	0	0	14083	1609	56	5	1502	5	SELO	22	50654274	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08	18108517	50654274	650292	126	45060											
MAGEB10	139422	broad.mit.edu	37	chrX	27839869	27839869	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaatgtccaagagccagtTccctgtaatcctgagcagag	12	8	9	12	0	0	3	0	1	0	2	3	3	3	3	5	0	2	3	5	0	3	2			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chrX:27839869T>A	uc004dbw.2	+	3	673	c.446T>A	c.(445-447)TTC>TAC	p.F149Y		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	149	MAGE.									lung(1)|breast(1)|central_nervous_system(1)	3						AAGAGCCAGTTCCCTGTAATC	0.438													23	30					0	0	0	0	A	27839869	A	A	27839869	3	1	245	1	0	0	0	0	1	0	0	0	9226	1783	62	5	448	5	MAGEB10	23	27839869	Missense_Mutation	SNP	T	TCGA-CV-7263-01A-11D-2012-08		27839869	127430691	127	45061											
MED12	9968	broad.mit.edu	37	chrX	70350030	70350030	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggacaatgaggatggggaaaAcccccagcggcagcgcataa	14	3	14	10	2	0	1	0	1	0	0	0	4	0	4	2	5	3	2	2	5	4	1			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chrX:70350030A>G	uc004dyy.2	+	28	4212	c.4013A>G	c.(4012-4014)AAC>AGC	p.N1338S	MED12_uc011mpq.1_Missense_Mutation_p.N1338S|MED12_uc004dyz.2_Missense_Mutation_p.N1338S|MED12_uc004dza.2_Missense_Mutation_p.N1185S|MED12_uc010nla.2_5'UTR	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1338					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GATGGGGAAAACCCCCAGCGG	0.577													2	11					0	0	0	0	G	70350030	G	G	70350030	3	3	245	1	0	0	0	0	1	0	0	0	9481	43	2	5	4123	5	MED12	23	70350030	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	42510161	70350030	84920530	128	45062											
XKRX	402415	broad.mit.edu	37	chrX	100183281	100183281	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggctcctcaggaatttcatAaactctgtccattgtcgagg	9	13	9	10	1	3	0	2	0	1	0	6	2	5	1	2	3	1	1	2	3	3	3			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chrX:100183281A>G	uc004egn.2	-	1	618	c.13T>C	c.(13-15)TAT>CAT	p.Y5H	XKRX_uc011mre.1_5'UTR	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	5						integral to membrane|plasma membrane				breast(1)	1						GGAATTTCATAAACTCTGTCC	0.488													72	65					0	0	0	0	G	100183281	G	G	100183281	3	3	245	1	0	0	0	0	1	0	0	0	17507	362	13	5	1348	5	XKRX	23	100183281	Missense_Mutation	SNP	A	TCGA-CV-7263-01A-11D-2012-08	29833251	100183281	55087279	129	45063											
CASZ1	54897	broad.mit.edu	37	chr1	10715845	10715857	+	Frame_Shift_Del	DEL	ATCACGTCCTGCT	-	-																															tgtgcatgttgtagtggcggAtcacgtcctgcttactcgtg																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:10715845_10715857delATCACGTCCTGCT	uc001aro.2	-	9	1834_1846	c.1514_1526delAGCAGGACGTGAT	c.(1513-1527)AAGCAGGACGTGATCfs	p.K505fs	CASZ1_uc001arp.1_Frame_Shift_Del_p.K505fs|CASZ1_uc009vmx.2_Frame_Shift_Del_p.K529fs	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	505_509					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GTAGTGGCGGATCACGTCCTGCTTACTCGTGAA	0.629													---	---	---								-	10715857	-	-	10715845	7	5	246	1	0	1	0	1	0	0	0	0	2697	333	12	0	3809	0	CASZ1	1	10715845	Frame_Shift_Del	DEL	ATCACGTCCTGCT	TCGA-CV-7406-01A-11D-2078-08		10715845	238534776	1	45064											
MAN1C1	57134	broad.mit.edu	37	chr1	25944551	25944551	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaacccggcccccgccgCgccggccccgggcgaggatg	4	2	14	21	7	0	0	0	0	0	0	1	2	1	1	8	4	1	0	8	4	1	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:25944551C>T	uc001bkm.2	+	1	593	c.263C>T	c.(262-264)GCG>GTG	p.A88V	MAN1C1_uc009vry.1_5'UTR	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	88	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		gcccccgccgcgccggccccg	0.642													4	7					0	0	0	0	T	25944551	T	T	25944551	3	4	246	1	0	0	0	0	1	0	0	0	9266	768	27	1	265	1	MAN1C1	1	25944551	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	15228706	25944551	223306070	2	45065											
MACF1	23499	broad.mit.edu	37	chr1	39801943	39801943	+	Frame_Shift_Del	DEL	A	-	-																															ttgtggaactctcaaatctgAaatagcaacacaggaactaa																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:39801943delA	uc010oiu.1	+	1	5134	c.5003delA	c.(5002-5004)GAAfs	p.E1668fs	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3233					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTCAAATCTGAAATAGCAACA	0.398													---	---	---								-	39801943	-	-	39801943	7	5	246	1	0	1	0	1	0	0	0	0	9195	246	9	0	9774	0	MACF1	1	39801943	Frame_Shift_Del	DEL	A	TCGA-CV-7406-01A-11D-2078-08	13857392	39801943	209448678	3	45066											
ZCCHC11	23318	broad.mit.edu	37	chr1	52911973	52911973	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttggaagtccactgcttctCaaaagttgtcaacagctttt	10	14	7	10	0	2	0	2	0	1	0	4	1	3	1	1	1	3	3	1	1	4	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:52911973C>G	uc001ctx.2	-	22	3889	c.3655G>C	c.(3655-3657)GAG>CAG	p.E1219Q	ZCCHC11_uc001cty.2_Missense_Mutation_p.E1219Q|ZCCHC11_uc001ctz.2_Missense_Mutation_p.E1219Q|ZCCHC11_uc009vze.1_Missense_Mutation_p.E1219Q|ZCCHC11_uc009vzf.1_Missense_Mutation_p.E940Q|ZCCHC11_uc001cua.1_Missense_Mutation_p.E136Q	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	1219	PAP-associated 2.				miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						CACTGCTTCTCAAAAGTTGTC	0.393													25	67					0	0	0	0	G	52911973	G	G	52911973	3	3	246	1	0	0	0	0	1	0	0	0	17647	835	29	2	1318	2	ZCCHC11	1	52911973	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	13110030	52911973	196338648	4	45067											
LRRC42	115353	broad.mit.edu	37	chr1	54423865	54423865	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaggagattaagtctttcCgggagctgacctgcctggat	8	12	13	8	1	1	3	0	2	1	1	2	6	2	5	3	3	2	1	3	3	1	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:54423865C>A	uc001cwj.1	+	3	717	c.517C>A	c.(517-519)CGG>AGG	p.R173R	LRRC42_uc001cwl.1_Silent_p.R173R|LRRC42_uc001cwk.1_Silent_p.R173R|LRRC42_uc009vzm.1_Silent_p.R173R	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	173											0						TAAGTCTTTCCGGGAGCTGAC	0.468													8	53					0.000274275	0.000280858	1	0	A	54423865	A	A	54423865	2	1	246	1	0	0	0	0	0	0	0	1	9050	643	23	3		3	LRRC42	1	54423865	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	1511892	54423865	194826756	5	45068											
CLCA2	9635	broad.mit.edu	37	chr1	86919185	86919185	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggcccccaccctgatgtGtttccaccatgcaaaattat	9	11	7	14	0	0	1	0	1	0	0	1	1	1	1	5	1	1	3	5	1	3	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:86919185G>T	uc001dlr.3	+	13	2451	c.2289G>T	c.(2287-2289)GTG>GTT	p.V763V		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	763	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		ACCCTGATGTGTTTCCACCAT	0.517													22	61					1.10513e-12	1.17392e-12	1	0	T	86919185	T	T	86919185	2	4	246	1	0	0	0	0	0	0	0	1	3473	1364	48	4		4	CLCA2	1	86919185	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	32495320	86919185	162331436	6	45069											
GBP1	2633	broad.mit.edu	37	chr1	89525943	89525944	+	Missense_Mutation	DNP	GT	TG	TG																															atgtggcctggcttcttgggGtggggcacacaccacatcca																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:89525943_89525944GT>TG	uc001dmx.2	-	3	474_475	c.254_255AC>CA	c.(253-255)CAC>CCA	p.H85P		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	85					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		GCTTCTTGGGGTGGGGCACACA	0.564													11	93					0	0	0	0	TG	89525944	TG	TG	89525943	3	4	246	1	0	0	0	0	1	0	0	0	6308	1252	44	4	1559	4	GBP1	1	89525943	Missense_Mutation	DNP	GT	TCGA-CV-7406-01A-11D-2078-08	2606758	89525943	159724678	7	45070											
COPA	1314	broad.mit.edu	37	chr1	160303419	160303419	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caggttctagattgccagttCcacactcggatggtctgatc	8	12	10	11	1	2	2	0	1	2	1	5	3	3	3	2	3	1	2	2	3	1	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:160303419C>T	uc009wti.2	-	5	754	c.360G>A	c.(358-360)TGG>TGA	p.W120*	COPA_uc001fvv.3_Nonsense_Mutation_p.W120*|COPA_uc009wtj.1_Nonsense_Mutation_p.W66*	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	120	WD 3.				COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATTGCCAGTTCCACACTCGGA	0.413													22	44					0	0	0	0	T	160303419	T	T	160303419	4	4	246	1	0	0	0	0	0	1	0	0	3742	856	30	2	3457	2	COPA	1	160303419	Nonsense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	70777476	160303419	88947202	8	45071											
F5	2153	broad.mit.edu	37	chr1	169525915	169525915	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggggtgagagaagatatGatccactttccctctgggcc	8	12	12	9	0	1	4	0	2	1	2	3	5	3	4	3	3	0	0	3	3	2	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:169525915G>A	uc001ggg.1	-	6	1066	c.921C>T	c.(919-921)ATC>ATT	p.I307I	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	307	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GAGAAGATATGATCCACTTTC	0.483													11	50					0	0	0	0	A	169525915	A	A	169525915	2	1	246	1	0	0	0	0	0	0	0	1	5373	1280	45	2		2	F5	1	169525915	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	9222496	169525915	79724706	9	45072											
C1orf129	80133	broad.mit.edu	37	chr1	170959143	170959143	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actacccagttccagcagacGagtaaggccccccaaccctc	11	5	7	18	1	0	1	0	0	0	1	2	2	1	1	6	1	3	3	6	1	3	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:170959143G>A	uc001ghg.2	+	11	1157	c.1027G>A	c.(1027-1029)GAC>AAC	p.D343N	C1orf129_uc009wvy.2_Missense_Mutation_p.D150N|C1orf129_uc010plz.1_Missense_Mutation_p.D343N	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	343							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TCCAGCAGACGAGTAAGGCCC	0.488													6	22					0	0	0	0	A	170959143	A	A	170959143	3	1	246	1	0	0	0	0	1	0	0	0	2005	1072	37	1	1065	1	C1orf129	1	170959143	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1433228	170959143	78291478	10	45073											
TOR3A	64222	broad.mit.edu	37	chr1	179063234	179063234	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgtctctttcagtaatctCaggggcgatataatcaatga	11	14	8	8	1	4	1	3	1	2	0	6	2	4	1	0	2	0	1	0	2	4	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:179063234C>T	uc001gmd.2	+	5	977	c.825C>T	c.(823-825)CTC>CTT	p.L275L	TOR3A_uc010pnd.1_Silent_p.L59L	NM_022371	NP_071766	Q9H497	TOR3A_HUMAN	torsin family 3, member A precursor	275					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			pancreas(1)	1						TCAGTAATCTCAGGGGCGATA	0.463													17	71					0	0	0	0	T	179063234	T	T	179063234	2	4	246	1	0	0	0	0	0	0	0	1	16443	813	29	2		2	TOR3A	1	179063234	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	8104091	179063234	70187387	11	45074											
DHX9	1660	broad.mit.edu	37	chr1	182835672	182835672	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggctacagcgttcgatttGagtctatacttcctcgtcct	6	15	9	11	3	1	1	0	1	1	0	5	2	3	1	2	1	3	2	2	1	3	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:182835672G>A	uc001gpr.2	+	13	1589	c.1426G>A	c.(1426-1428)GAG>AAG	p.E476K	DHX9_uc001gps.2_Missense_Mutation_p.E262K	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	476	Helicase ATP-binding.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						CGTTCGATTTGAGTCTATACT	0.428													57	151					0	0	0	0	A	182835672	A	A	182835672	3	1	246	1	0	0	0	0	1	0	0	0	4538	1291	45	2	1472	2	DHX9	1	182835672	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	3772438	182835672	66414949	12	45075											
B3GALNT2	148789	broad.mit.edu	37	chr1	235634193	235634193	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgagaactccccctccatCattcactgtcactttgtgga	8	13	6	14	0	4	1	3	1	1	1	6	3	6	2	3	1	1	0	3	1	1	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:235634193C>A	uc001hxc.2	-	6	962	c.733G>T	c.(733-735)GAT>TAT	p.D245Y	B3GALNT2_uc001hxd.1_Missense_Mutation_p.D286Y	NM_152490	NP_689703	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	245	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			breast(1)	1	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			CCCCCTCCATCATTCACTGTC	0.358													29	74					2.46105e-21	2.65835e-21	1	0	A	235634193	A	A	235634193	3	1	246	1	0	0	0	0	1	0	0	0	1248	826	29	2	797	2	B3GALNT2	1	235634193	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	52798521	235634193	13616428	13	45076											
SCCPDH	51097	broad.mit.edu	37	chr1	246927581	246927581	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cattcacgctgacattctttGgtcaaggatacagccaaggc	11	10	9	11	1	3	1	2	1	1	0	3	2	3	2	1	3	2	1	1	3	3	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:246927581G>A	uc001ibr.2	+	10	1371	c.1024G>A	c.(1024-1026)GGT>AGT	p.G342S		NM_016002	NP_057086	Q8NBX0	SCPDH_HUMAN	saccharopine dehydrogenase (putative)	342						midbody	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity			ovary(1)	1	all_cancers(71;6.8e-05)|all_epithelial(71;7.93e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0545)|Lung NSC(105;0.0618)	all_cancers(173;0.0343)	OV - Ovarian serous cystadenocarcinoma(106;0.00323)	GBM - Glioblastoma multiforme(49;0.0896)		GACATTCTTTGGTCAAGGATA	0.408													22	64					0	0	0	0	A	246927581	A	A	246927581	3	1	246	1	0	0	0	0	1	0	0	0	13950	1348	47	4	1062	4	SCCPDH	1	246927581	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	11293388	246927581	2323040	14	45077											
OR11L1	391189	broad.mit.edu	37	chr1	248005106	248005106	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtcaggcagtagatgagcagGaaaatgacaaagagcagggc	16	4	15	6	0	1	4	1	2	0	2	1	5	1	5	0	3	2	4	0	3	4	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:248005106G>T	uc001idn.1	-	1	93	c.93C>A	c.(91-93)TTC>TTA	p.F31L		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGATGAGCAGGAAAATGACAA	0.507													11	36					5.50884e-06	5.68654e-06	1	0	T	248005106	T	T	248005106	3	4	246	1	0	0	0	0	1	0	0	0	10984	1165	41	2	879	2	OR11L1	1	248005106	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1077525	248005106	1245515	15	45078											
PGBD2	267002	broad.mit.edu	37	chr1	249211968	249211968	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaactgaaaaaaatgaagagGggttcatttgattacaaagt	18	10	10	3	0	1	4	1	3	0	1	1	5	1	4	0	2	2	1	0	2	7	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr1:249211968G>T	uc001ifh.2	+	3	1332	c.1185G>T	c.(1183-1185)AGG>AGT	p.R395S	PGBD2_uc001ifg.2_Missense_Mutation_p.R144S|PGBD2_uc009xhd.2_Missense_Mutation_p.R392S	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	395										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AAATGAAGAGGGGTTCATTTG	0.478													21	49					4.35082e-09	4.56479e-09	1	0	T	249211968	T	T	249211968	3	4	246	1	0	0	0	0	1	0	0	0	11836	1223	43	4	1191	4	PGBD2	1	249211968	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1206862	249211968	38653	16	45079											
CLEC4F	165530	broad.mit.edu	37	chr2	71046980	71046980	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggggtagcctgaacgagcctCggtatcttgggggctgcagg	6	8	18	9	2	1	1	0	1	1	0	2	2	1	1	2	6	4	4	2	6	3	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:71046980C>T	uc002shf.2	-	2	182	c.105G>A	c.(103-105)CCG>CCA	p.P35P	CLEC4F_uc010yqv.1_Silent_p.P35P	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	35	Cytoplasmic (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						GAACGAGCCTCGGTATCTTGG	0.567													12	30					0	0	0	0	T	71046980	T	T	71046980	2	4	246	1	0	0	0	0	0	0	0	1	3531	871	31	1		1	CLEC4F	2	71046980	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08		71046980	172152393	17	45080											
PCGF1	84759	broad.mit.edu	37	chr2	74734013	74734013	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatacaactcttgcagacTgcaggaaaagaaaagcagat	19	6	8	8	0	1	3	0	0	1	3	1	4	1	4	0	1	5	3	0	1	7	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:74734013T>C	uc002slz.2	-	3	226	c.200_splice	c.e3-1	p.F67_splice	PCGF1_uc002sly.2_Splice_Site	NM_032673	NP_116062	Q9BSM1	PCGF1_HUMAN	polycomb group ring finger 1						histone H2A monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	protein C-terminus binding|zinc ion binding			ovary(1)	1						TCTTGCAGACTGCAGGAAAAG	0.527													18	49					0	0	0	0	C	74734013	C	C	74734013	5	2	246	1	0	0	0	0	0	0	1	0	11628	1594	55	5	609	5	PCGF1	2	74734013	Splice_Site	SNP	T	TCGA-CV-7406-01A-11D-2078-08	3687033	74734013	168465360	18	45081											
LRRTM1	347730	broad.mit.edu	37	chr2	80530936	80530936	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agacagagaccgagcagcagGaaatccattagcgagaatct	16	5	11	9	2	1	3	0	0	1	3	2	7	2	4	2	1	3	2	2	1	3	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:80530936G>A	uc002sok.1	-	2	279	c.9C>T	c.(7-9)TTC>TTT	p.F3F	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	3						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CGAGCAGCAGGAAATCCATTA	0.557										HNSCC(69;0.2)			11	42					0	0	0	0	A	80530936	A	A	80530936	2	1	246	1	0	0	0	0	0	0	0	1	9089	1165	41	2		2	LRRTM1	2	80530936	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	5796923	80530936	162668437	19	45082											
NCKAP5	344148	broad.mit.edu	37	chr2	133543004	133543004	+	Frame_Shift_Del	DEL	G	-	-																															gtcttgtggggttccttgcaGgggctccccaggtcagctgt																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:133543004delG	uc002ttp.2	-	14	1754	c.1380delC	c.(1378-1380)CCCfs	p.P460fs	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	460							protein binding				0						GTTCCTTGCAGGGGCTCCCCA	0.478													---	---	---								-	133543004	-	-	133543004	7	5	246	1	0	1	0	1	0	0	0	0	10277	987	35	0	4377	0	NCKAP5	2	133543004	Frame_Shift_Del	DEL	G	TCGA-CV-7406-01A-11D-2078-08	53012068	133543004	109656369	20	45083											
GALNT5	11227	broad.mit.edu	37	chr2	158115183	158115183	+	Frame_Shift_Del	DEL	C	-	-																															gtgtcagtttaaaacaggagCcccggaagagtcatagtccc																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:158115183delC	uc002tzg.2	+	1	844	c.589delC	c.(589-591)CCCfs	p.P197fs	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	197	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						AAAACAGGAGCCCCGGAAGAG	0.473													---	---	---								-	158115183	-	-	158115183	7	5	246	1	0	1	0	1	0	0	0	0	6251	739	26	0	591	0	GALNT5	2	158115183	Frame_Shift_Del	DEL	C	TCGA-CV-7406-01A-11D-2078-08	24572179	158115183	85084190	21	45084											
GALNT5	11227	broad.mit.edu	37	chr2	158115563	158115563	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctctgaaagccatcttgtGattataaccaaagaggaaga	15	11	8	7	0	2	4	0	2	2	2	3	5	2	5	2	1	2	0	2	1	5	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:158115563G>C	uc002tzg.2	+	1	1224	c.969G>C	c.(967-969)GTG>GTC	p.V323V	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	323	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						GCCATCTTGTGATTATAACCA	0.388													27	72					0	0	0	0	C	158115563	C	C	158115563	2	2	246	1	0	0	0	0	0	0	0	1	6251	1277	45	2		2	GALNT5	2	158115563	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	380	158115563	85083810	22	45085											
TTN	7273	broad.mit.edu	37	chr2	179449657	179449657	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaagcatcagcgtctatatCagaaatgtcaaatggaggct	14	9	10	8	1	4	1	3	0	1	1	4	2	4	2	0	2	2	3	0	2	5	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:179449657C>T	uc010zfg.1	-	259	57231	c.57007G>A	c.(57007-57009)GAT>AAT	p.D19003N	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D12698N|TTN_uc010zfi.1_Missense_Mutation_p.D12631N|TTN_uc010zfj.1_Missense_Mutation_p.D12506N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19930							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCGTCTATATCAGAAATGTCA	0.458													24	39					0	0	0	0	T	179449657	T	T	179449657	3	4	246	1	0	0	0	0	1	0	0	0	16803	826	29	2	43480	2	TTN	2	179449657	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	21334094	179449657	63749716	23	45086											
STAT1	6772	broad.mit.edu	37	chr2	191874723	191874723	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctgaagttcgtaccactGagacatcctatagggaaaaa	14	9	9	9	1	0	2	0	2	0	1	2	4	1	3	2	1	2	3	2	1	6	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:191874723G>A	uc002usj.2	-	3	395	c.7C>T	c.(7-9)CAG>TAG	p.Q3*	STAT1_uc010fse.1_Nonsense_Mutation_p.Q3*|STAT1_uc002usk.2_Nonsense_Mutation_p.Q3*|STAT1_uc002usl.2_Nonsense_Mutation_p.Q5*|STAT1_uc010fsf.1_5'UTR	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	3					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TCGTACCACTGAGACATCCTA	0.403													18	22					0	0	0	0	A	191874723	A	A	191874723	4	1	246	1	0	0	0	0	0	1	0	0	15330	1299	45	2	2341	2	STAT1	2	191874723	Nonsense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	12425066	191874723	51324650	24	45087											
ALS2CR12	130540	broad.mit.edu	37	chr2	202173910	202173910	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttctcgctcgaacttctCatccttcttccatttcgcct	5	18	3	15	3	3	0	1	0	3	0	9	1	5	0	3	0	1	1	3	0	1	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:202173910C>T	uc010ftg.2	-	10	1183	c.739G>A	c.(739-741)GAG>AAG	p.E247K	ALS2CR12_uc002uya.3_Missense_Mutation_p.E247K|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	247					regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TCGAACTTCTCATCCTTCTTC	0.408													43	64					0	0	0	0	T	202173910	T	T	202173910	3	4	246	1	0	0	0	0	1	0	0	0	553	835	29	2	622	2	ALS2CR12	2	202173910	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	10299187	202173910	41025463	25	45088											
NBEAL1	65065	broad.mit.edu	37	chr2	204009620	204009620	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaatggcaagtttacattGaaaaatatgtaagttttatc	16	15	7	3	0	0	2	0	2	0	0	1	2	0	2	0	1	1	4	0	1	8	7			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr2:204009620G>C	uc002uzt.3	+	31	5392	c.5059G>C	c.(5059-5061)GAA>CAA	p.E1687Q	NBEAL1_uc002uzs.3_Missense_Mutation_p.E397Q	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1687							binding			ovary(1)|skin(1)	2						AGTTTACATTGAAAAATATGT	0.249													6	8					0	0	0	0	C	204009620	C	C	204009620	3	2	246	1	0	0	0	0	1	0	0	0	10241	1291	45	2	5177	2	NBEAL1	2	204009620	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1835710	204009620	39189753	26	45089											
SLC6A1	6529	broad.mit.edu	37	chr3	11059596	11059596	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccactcttcctgctggagtgCtccctgggccagtacacctc	5	10	9	17	0	1	0	0	0	1	0	4	1	3	1	5	2	3	3	5	2	1	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:11059596C>T	uc010hdq.2	+	4	717	c.306C>T	c.(304-306)TGC>TGT	p.C102C		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	102					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TGCTGGAGTGCTCCCTGGGCC	0.592													43	91					0	0	0	0	T	11059596	T	T	11059596	2	4	246	1	0	0	0	0	0	0	0	1	14737	805	28	4		4	SLC6A1	3	11059596	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08		11059596	186962834	27	45090											
HACL1	26061	broad.mit.edu	37	chr3	15613185	15613185	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgattttaccttggatgcaGcttcattgctcttcattttt	6	19	6	10	1	3	0	2	0	1	0	3	2	3	1	2	1	4	3	2	1	1	8			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:15613185G>A	uc003caf.2	-	12	1245	c.1085C>T	c.(1084-1086)GCT>GTT	p.A362V	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Missense_Mutation_p.A335V|HACL1_uc011avt.1_Intron|HACL1_uc003cag.2_Missense_Mutation_p.A6V|HACL1_uc011avu.1_Missense_Mutation_p.A280V|HACL1_uc010hep.2_Missense_Mutation_p.A121V	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	362					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						CTTGGATGCAGCTTCATTGCT	0.323													15	76					0	0	0	0	A	15613185	A	A	15613185	3	1	246	1	0	0	0	0	1	0	0	0	6980	971	34	4	675	4	HACL1	3	15613185	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	4553589	15613185	182409245	28	45091											
KCNH8	131096	broad.mit.edu	37	chr3	19492809	19492809	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctccgggggagtatctgctgCgtcaaggggatgctttgcag	6	10	16	9	2	2	0	1	0	1	0	3	2	3	2	1	4	4	4	1	4	2	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:19492809C>T	uc003cbk.1	+	10	1933	c.1738C>T	c.(1738-1740)CGT>TGT	p.R580C	KCNH8_uc011awe.1_3'UTR|KCNH8_uc010hex.1_Missense_Mutation_p.R41C|KCNH8_uc011awf.1_3'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	580	cNMP.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						GTATCTGCTGCGTCAAGGGGA	0.507													29	59					0	0	0	0	T	19492809	T	T	19492809	3	4	246	1	0	0	0	0	1	0	0	0	8077	768	27	1	1776	1	KCNH8	3	19492809	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	3879624	19492809	178529621	29	45092											
CCR3	1232	broad.mit.edu	37	chr3	46307508	46307508	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctggtcatgctggtgacaGaggtgatcgcctactcccac	8	9	11	13	1	1	3	1	2	0	1	3	3	2	3	3	3	2	1	3	3	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:46307508G>C	uc003cpg.1	+	4	1402	c.859G>C	c.(859-861)GAG>CAG	p.E287Q	CCR3_uc003cpi.1_Missense_Mutation_p.E287Q|CCR3_uc003cpj.1_Missense_Mutation_p.E287Q|CCR3_uc003cpk.1_Missense_Mutation_p.E308Q|CCR3_uc010hjb.1_Missense_Mutation_p.E305Q|CCR3_uc003cpl.1_Missense_Mutation_p.E320Q	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	287	Helical; Name=7; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		GCTGGTGACAGAGGTGATCGC	0.517													22	27					0	0	0	0	C	46307508	C	C	46307508	3	2	246	1	0	0	0	0	1	0	0	0	2957	943	33	2	928	2	CCR3	3	46307508	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	26814699	46307508	151714922	30	45093											
CELSR3	1951	broad.mit.edu	37	chr3	48689469	48689469	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagccagagggtgtggagcCgagccacaccccctgtggac	8	4	16	13	1	0	1	0	0	0	1	0	5	0	4	5	4	3	0	5	4	0	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:48689469C>T	uc003cul.2	-	12	6045	c.5764G>A	c.(5764-5766)GGC>AGC	p.G1922S	CELSR3_uc003cuf.1_Missense_Mutation_p.G1992S|CELSR3_uc010hkg.2_5'UTR	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1922	Extracellular (Potential).|Laminin G-like 2.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTGTGGAGCCGAGCCACACC	0.647													3	28					0	0	0	0	T	48689469	T	T	48689469	3	4	246	1	0	0	0	0	1	0	0	0	3238	652	23	1	4270	1	CELSR3	3	48689469	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	2381961	48689469	149332961	31	45094											
BSN	8927	broad.mit.edu	37	chr3	49694791	49694791	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgctacctcttgagtcggcGacgccgggcacggcggagtg	5	6	16	14	7	1	1	0	1	1	0	2	3	1	2	3	4	1	2	3	4	1	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:49694791G>A	uc003cxe.3	+	5	7916	c.7802G>A	c.(7801-7803)CGA>CAA	p.R2601Q		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2601	Poly-Arg.				synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TTGAGTCGGCGACGCCGGGCA	0.647													14	32					0	0	0	0	A	49694791	A	A	49694791	3	1	246	1	0	0	0	0	1	0	0	0	1535	1058	37	1	7820	1	BSN	3	49694791	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1005322	49694791	148327639	32	45095											
CAMKV	79012	broad.mit.edu	37	chr3	49898901	49898907	+	Frame_Shift_Del	DEL	AGTGCAA	-	-																															cctgtgcacgatcttgagtgAgtgcaaataggccacggcct																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:49898901_49898907delAGTGCAA	uc003cxt.1	-	5	599_605	c.406_412delTTGCACT	c.(406-414)TTGCACTCAfs	p.L136fs	CAMKV_uc011bcy.1_Frame_Shift_Del_p.L61fs|CAMKV_uc003cxv.1_Frame_Shift_Del_p.L136fs|CAMKV_uc003cxw.1_5'UTR|CAMKV_uc003cxx.1_5'UTR|CAMKV_uc003cxu.2_Frame_Shift_Del_p.L136fs|CAMKV_uc011bcz.1_Frame_Shift_Del_p.L99fs|CAMKV_uc011bda.1_Intron|CAMKV_uc011bdb.1_RNA	NM_024046	NP_076951	Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	136_138	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|large_intestine(2)|central_nervous_system(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ATCTTGAGTGAGTGCAAATAGGCCACG	0.609													---	---	---								-	49898907	-	-	49898901	7	5	246	1	0	1	0	1	0	0	0	0	2620	304	11	0	1121	0	CAMKV	3	49898901	Frame_Shift_Del	DEL	AGTGCAA	TCGA-CV-7406-01A-11D-2078-08	204110	49898901	148123529	33	45096											
DOCK3	1795	broad.mit.edu	37	chr3	51411927	51411927	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctctgccagataagtaccGccatgcccgtgaaatgatgt	10	10	9	12	2	1	3	0	2	1	1	2	3	1	3	4	0	3	1	4	0	3	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:51411927G>A	uc011bds.1	+	50	5344	c.5321G>A	c.(5320-5322)CGC>CAC	p.R1774H		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1774						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GATAAGTACCGCCATGCCCGT	0.537													4	11					0	0	0	0	A	51411927	A	A	51411927	3	1	246	1	0	0	0	0	1	0	0	0	4710	1087	38	1	5519	1	DOCK3	3	51411927	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1513026	51411927	146610503	34	45097											
OR5H14	403273	broad.mit.edu	37	chr3	97868899	97868899	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttacatatttgtcctctatAcaatcttgaaaaagaagtct	14	15	4	8	0	3	2	0	1	3	1	4	2	4	2	1	0	2	0	1	0	8	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:97868899A>G	uc003dsg.1	+	1	670	c.670A>G	c.(670-672)ACA>GCA	p.T224A		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGTCCTCTATACAATCTTGAA	0.358													12	37					0	0	0	0	G	97868899	G	G	97868899	3	3	246	1	0	0	0	0	1	0	0	0	11214	391	14	5	672	5	OR5H14	3	97868899	Missense_Mutation	SNP	A	TCGA-CV-7406-01A-11D-2078-08	46456972	97868899	100153531	35	45098											
IMPG2	50939	broad.mit.edu	37	chr3	100995541	100995541	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agtatcaccaacaggaactgGagaagacagttcagagctag	16	6	11	8	0	2	3	2	0	0	3	2	5	2	4	1	2	3	3	1	2	5	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:100995541G>C	uc003duq.1	-	5	753	c.550C>G	c.(550-552)CCA>GCA	p.P184A	IMPG2_uc011bhe.1_Missense_Mutation_p.P47A	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	184	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						ACAGGAACTGGAGAAGACAGT	0.333													4	18					0	0	0	0	C	100995541	C	C	100995541	3	2	246	1	0	0	0	0	1	0	0	0	7768	1174	41	2	3235	2	IMPG2	3	100995541	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	3126642	100995541	97026889	36	45099											
NR1I2	8856	broad.mit.edu	37	chr3	119528935	119528935	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaaacgcaacgcccggctGaggtgccccttccggaaggg	9	5	14	13	4	0	2	0	2	0	0	1	3	1	3	4	4	3	2	4	4	3	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:119528935G>A	uc003edj.2	+	3	2064	c.225G>A	c.(223-225)CTG>CTA	p.L75L	NR1I2_uc003edi.2_Silent_p.L75L|NR1I2_uc003edk.2_Silent_p.L114L|NR1I2_uc003edl.2_5'Flank	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	75	Nuclear receptor.|Bipartite nuclear localization signal.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	ACGCCCGGCTGAGGTGCCCCT	0.697													10	58					0	0	0	0	A	119528935	A	A	119528935	2	1	246	1	0	0	0	0	0	0	0	1	10674	1277	45	2		2	NR1I2	3	119528935	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	18533394	119528935	78493495	37	45100											
GOLGB1	2804	broad.mit.edu	37	chr3	121448138	121448138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagaagttaatttggccttcGcatgaagttttagtttttta	11	18	8	4	1	0	2	0	1	0	1	1	2	0	2	1	1	0	4	1	1	6	8			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:121448138G>A	uc003eei.3	-	4	425	c.299C>T	c.(298-300)GCG>GTG	p.A100V	GOLGB1_uc010hrc.2_Missense_Mutation_p.A100V|GOLGB1_uc003eej.3_Missense_Mutation_p.A61V|GOLGB1_uc011bjm.1_Missense_Mutation_p.A61V|GOLGB1_uc010hrd.1_Missense_Mutation_p.A100V	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	100	Potential.|Cytoplasmic (Potential).				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTTGGCCTTCGCATGAAGTTT	0.363													20	115					0	0	0	0	A	121448138	A	A	121448138	3	1	246	1	0	0	0	0	1	0	0	0	6602	1087	38	1	9556	1	GOLGB1	3	121448138	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1919203	121448138	76574292	38	45101											
PLXNA1	5361	broad.mit.edu	37	chr3	126735460	126735460	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgcccagctcaccaaccctGaggtgaagtacaactacacc	12	5	8	16	1	1	2	1	2	0	0	1	2	1	2	4	1	5	2	4	1	5	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:126735460G>C	uc003ejg.2	+	15	3050	c.3046G>C	c.(3046-3048)GAG>CAG	p.E1016Q		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1039	IPT/TIG 2.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CACCAACCCTGAGGTGAAGTA	0.622													21	107					0	0	0	0	C	126735460	C	C	126735460	3	2	246	1	0	0	0	0	1	0	0	0	12174	1291	45	2	3173	2	PLXNA1	3	126735460	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	5287322	126735460	71286970	39	45102											
KBTBD12	166348	broad.mit.edu	37	chr3	127642957	127642957	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctctagacaaaagaacaaGaatgttgaaatttataggtt	17	12	7	5	0	1	4	0	1	1	3	2	4	1	4	0	1	1	2	0	1	9	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:127642957G>A	uc010hsr.2	+	1	1056	c.1053G>A	c.(1051-1053)AAG>AAA	p.K351K	KBTBD12_uc003ejy.3_Intron|KBTBD12_uc010hsq.2_Intron|KBTBD12_uc003eka.3_Intron|KBTBD12_uc003ejz.2_Silent_p.K351K	NM_207335	NP_997218	Q3ZCT8	KBTBC_HUMAN	kelch domain containing 6	351										ovary(1)	1						AAAAGAACAAGAATGTTGAAA	0.348													18	87					0	0	0	0	A	127642957	A	A	127642957	2	1	246	1	0	0	0	0	0	0	0	1	8030	933	33	2		2	KBTBD12	3	127642957	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	907497	127642957	70379473	40	45103											
ARMC8	25852	broad.mit.edu	37	chr3	137956364	137956364	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccacagatttttgtgaaGatgttacagagggataagcc	13	12	10	6	0	0	4	0	1	0	3	0	5	0	5	2	1	3	1	2	1	4	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:137956364G>T	uc003esa.1	+	10	1051	c.684G>T	c.(682-684)AAG>AAT	p.K228N	ARMC8_uc003erw.2_Missense_Mutation_p.K228N|ARMC8_uc003erx.2_Missense_Mutation_p.K228N|ARMC8_uc003ery.2_Missense_Mutation_p.K200N|ARMC8_uc003erz.2_Missense_Mutation_p.K200N|ARMC8_uc011bmf.1_Missense_Mutation_p.K211N|ARMC8_uc011bmg.1_Missense_Mutation_p.K242N|ARMC8_uc011bmh.1_Missense_Mutation_p.K169N|ARMC8_uc003esb.1_Missense_Mutation_p.K200N|ARMC8_uc003esc.1_5'UTR	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	242	ARM 5.						binding				0						TTTTTGTGAAGATGTTACAGA	0.328													11	66					0.00400662	0.00408644	1	0	T	137956364	T	T	137956364	3	4	246	1	0	0	0	0	1	0	0	0	959	933	33	2	718	2	ARMC8	3	137956364	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	10313407	137956364	60066066	41	45104											
RASA2	5922	broad.mit.edu	37	chr3	141328818	141328818	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtaacaacctttaagacaaTtcagcaaataaaaagcataa	21	9	4	7	0	1	1	1	0	0	1	1	1	1	1	1	0	4	3	1	0	9	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:141328818T>G	uc003etz.1	+	23	2429	c.2429T>G	c.(2428-2430)ATT>AGT	p.I810S	RASA2_uc010huq.1_Missense_Mutation_p.I814S|RASA2_uc003eua.1_Missense_Mutation_p.I811S|uc003eub.2_5'Flank	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	810					intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						TTTAAGACAATTCAGCAAATA	0.363													20	86					0	0	0	0	G	141328818	G	G	141328818	3	3	246	1	0	0	0	0	1	0	0	0	13126	1493	52	5	2519	5	RASA2	3	141328818	Missense_Mutation	SNP	T	TCGA-CV-7406-01A-11D-2078-08	3372454	141328818	56693612	42	45105											
PCOLCE2	26577	broad.mit.edu	37	chr3	142607677	142607677	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctctggggactgctgccgcGagagctgggtggcggcagcc	4	7	18	12	3	1	1	0	0	1	1	2	3	1	2	2	5	4	3	2	5	0	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:142607677G>A	uc003evd.2	-	1	258	c.62C>T	c.(61-63)TCG>TTG	p.S21L		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	21						extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						CTGCTGCCGCGAGAGCTGGGT	0.692													3	14					0	0	0	0	A	142607677	A	A	142607677	3	1	246	1	0	0	0	0	1	0	0	0	11649	1059	37	1	1221	1	PCOLCE2	3	142607677	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1278859	142607677	55414753	43	45106											
CP	1356	broad.mit.edu	37	chr3	148905959	148905959	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	attctcatcaaatactgtagGaaacaaatagaattccttgt	16	13	5	7	0	2	1	2	0	1	1	4	2	3	2	1	1	2	1	1	1	7	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:148905959G>A	uc003ewy.3	-	10	1997	c.1744C>T	c.(1744-1746)CCT>TCT	p.P582S	CP_uc011bnr.1_RNA|CP_uc003ewx.3_Missense_Mutation_p.P363S|CP_uc003ewz.2_Missense_Mutation_p.P582S|CP_uc010hvf.1_Missense_Mutation_p.P308S	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	582	Plastocyanin-like 4.|F5/8 type A 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	AATACTGTAGGAAACAAATAG	0.343													22	82					0	0	0	0	A	148905959	A	A	148905959	3	1	246	1	0	0	0	0	1	0	0	0	3802	1174	41	2	1493	2	CP	3	148905959	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	6298282	148905959	49116471	44	45107											
SLC33A1	9197	broad.mit.edu	37	chr3	155560316	155560316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctgtgatcccttgtgtttCttcttttactactgatactt	6	21	5	9	0	3	2	0	2	3	0	4	2	4	2	1	0	3	1	1	0	3	8			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:155560316C>T	uc003fan.3	-	2	1249	c.868G>A	c.(868-870)GAA>AAA	p.E290K	SLC33A1_uc003fao.1_Missense_Mutation_p.E290K	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	290	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCTTGTGTTTCTTCTTTTACT	0.338													6	46					0	0	0	0	T	155560316	T	T	155560316	3	4	246	1	0	0	0	0	1	0	0	0	14630	922	32	2	801	2	SLC33A1	3	155560316	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	6654357	155560316	42462114	45	45108											
ZBBX	79740	broad.mit.edu	37	chr3	167033577	167033577	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagctaatttaactttgtaaGgcacaatattttctgcttct	11	17	5	8	0	2	0	0	0	2	0	2	0	2	0	0	1	3	4	0	1	5	9			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:167033577G>C	uc003fep.2	-	15	1558	c.1235C>G	c.(1234-1236)CCT>CGT	p.P412R	ZBBX_uc011bpc.1_Missense_Mutation_p.P412R|ZBBX_uc003feq.2_Missense_Mutation_p.P383R	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	412						intracellular	zinc ion binding			ovary(2)	2						AACTTTGTAAGGCACAATATT	0.284													10	41					0	0	0	0	C	167033577	C	C	167033577	3	2	246	1	0	0	0	0	1	0	0	0	17584	1000	35	4	1195	4	ZBBX	3	167033577	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	11473261	167033577	30988853	46	45109											
TNIK	23043	broad.mit.edu	37	chr3	170784400	170784409	+	Frame_Shift_Del	DEL	ACATCCTTAG	-	-																															tttctccccattggagcaccAcatccttagttatccggcca																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:170784400_170784409delACATCCTTAG	uc003fhh.2	-	31	4160_4169	c.3815_3824delCTAAGGATGT	c.(3814-3825)ACTAAGGATGTGfs	p.T1272fs	TNIK_uc003fhi.2_Frame_Shift_Del_p.T1217fs|TNIK_uc003fhj.2_Frame_Shift_Del_p.T1243fs|TNIK_uc003fhk.2_Frame_Shift_Del_p.T1264fs|TNIK_uc003fhl.2_Frame_Shift_Del_p.T1188fs|TNIK_uc003fhm.2_Frame_Shift_Del_p.T1209fs|TNIK_uc003fhn.2_Frame_Shift_Del_p.T1235fs|TNIK_uc003fho.2_Frame_Shift_Del_p.T1180fs|TNIK_uc003fhg.2_Frame_Shift_Del_p.T450fs|TNIK_uc003fhp.2_Frame_Shift_Del_p.T204fs	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1272_1275	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TTGGAGCACCACATCCTTAGTTATCCGGCC	0.448													---	---	---								-	170784409	-	-	170784400	7	5	246	1	0	1	0	1	0	0	0	0	16379	159	6	0	270	0	TNIK	3	170784400	Frame_Shift_Del	DEL	ACATCCTTAG	TCGA-CV-7406-01A-11D-2078-08	3750823	170784400	27238030	47	45110											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	62					0	0	0	0	A	178936091	A	A	178936091	3	1	246	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	8151691	178936091	19086339	48	45111											
HTR3D	200909	broad.mit.edu	37	chr3	183756393	183756393	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaataagggcccgggtctCacccccacccacctgcccgg	8	4	11	18	2	1	0	1	0	1	0	2	1	1	1	6	4	1	0	6	4	2	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:183756393C>T	uc011bqv.1	+	7	1116	c.1116C>T	c.(1114-1116)CTC>CTT	p.L372L	HTR3D_uc003fmj.2_Silent_p.L197L|HTR3D_uc011bqu.1_Silent_p.L322L|HTR3D_uc010hxp.2_Silent_p.L151L	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	372	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCCCGGGTCTCACCCCCACCC	0.453													4	30					0	0	0	0	T	183756393	T	T	183756393	2	4	246	1	0	0	0	0	0	0	0	1	7486	813	29	2		2	HTR3D	3	183756393	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	4820302	183756393	14266037	49	45112											
ECE2	9718	broad.mit.edu	37	chr3	184005699	184005699	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgctttggggtccctcttCgtgaaggccacgtttgaccg	4	14	12	11	3	1	2	0	2	1	0	3	2	2	2	3	3	1	2	3	3	1	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:184005699C>T	uc003fni.3	+	11	1730	c.1692C>T	c.(1690-1692)TTC>TTT	p.F564F	ECE2_uc011brh.1_Silent_p.F417F|ECE2_uc003fnl.3_Silent_p.F492F|ECE2_uc003fnm.3_Silent_p.F446F|ECE2_uc003fnk.3_Silent_p.F417F|ECE2_uc011bri.1_Silent_p.F479F|ECE2_uc010hxv.2_Silent_p.F208F	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	564	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGTCCCTCTTCGTGAAGGCCA	0.498													15	58					0	0	0	0	T	184005699	T	T	184005699	2	4	246	1	0	0	0	0	0	0	0	1	4912	883	31	1		1	ECE2	3	184005699	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	249306	184005699	14016731	50	45113											
CHRD	8646	broad.mit.edu	37	chr3	184104374	184104374	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggggctccggatacagcctCtgctgcgccgcctgtggtgc	3	8	16	14	3	1	0	0	0	1	0	2	1	2	1	4	4	5	2	4	4	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:184104374C>G	uc003fov.2	+	16	2273	c.2027C>G	c.(2026-2028)TCT>TGT	p.S676C	CHRD_uc003fow.2_Missense_Mutation_p.S306C|CHRD_uc003fox.2_Missense_Mutation_p.S676C|CHRD_uc003foy.2_Missense_Mutation_p.S306C|CHRD_uc010hyc.2_Missense_Mutation_p.S266C|CHRD_uc011brr.1_Intron	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	676					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GATACAGCCTCTGCTGCGCCG	0.711													5	10					0	0	0	0	G	184104374	G	G	184104374	3	3	246	1	0	0	0	0	1	0	0	0	3387	913	32	2	2089	2	CHRD	3	184104374	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	98675	184104374	13918056	51	45114											
RTP1	132112	broad.mit.edu	37	chr3	186917628	186917628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggacaaccggcggcaccgcGgagagttctgcgaggcctgc	8	4	16	13	5	1	1	0	0	1	1	1	4	1	2	3	5	3	2	3	5	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:186917628G>A	uc003frg.2	+	2	592	c.562G>A	c.(562-564)GGA>AGA	p.G188R		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	188	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		GCGGCACCGCGGAGAGTTCTG	0.692													10	37					0	0	0	0	A	186917628	A	A	186917628	3	1	246	1	0	0	0	0	1	0	0	0	13798	1117	39	1	568	1	RTP1	3	186917628	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	2813254	186917628	11104802	52	45115											
C3orf59	151963	broad.mit.edu	37	chr3	192516720	192516720	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgatggctttgcaggcctGataggcctgcatgaggctgc	7	10	15	9	0	0	3	0	3	0	0	0	4	0	3	2	4	3	4	2	4	1	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:192516720G>C	uc011bsp.1	-	2	1252	c.931C>G	c.(931-933)CAG>GAG	p.Q311E		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	311											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGCAGGCCTGATAGGCCTGC	0.557													14	48					0	0	0	0	C	192516720	C	C	192516720	3	2	246	1	0	0	0	0	1	0	0	0	2247	1299	45	2	548	2	C3orf59	3	192516720	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	5599092	192516720	5505710	53	45116											
LSG1	55341	broad.mit.edu	37	chr3	194362968	194362968	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcctttggtcaaagccctCacattctcctaggaaataag	12	11	6	12	0	3	0	2	0	1	0	5	1	4	1	3	2	1	0	3	2	4	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:194362968C>G	uc003fui.2	-	14	2121	c.1806G>C	c.(1804-1806)GTG>GTC	p.V602V		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	602					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		TCAAAGCCCTCACATTCTCCT	0.488													14	53					0	0	0	0	G	194362968	G	G	194362968	2	3	246	1	0	0	0	0	0	0	0	1	9099	813	29	2		2	LSG1	3	194362968	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	1846248	194362968	3659462	54	45117											
C3orf21	152002	broad.mit.edu	37	chr3	194991445	194991445	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcgacgcgggccttggcctGcagcgcggcattgtgctccg	3	7	16	15	7	0	0	0	0	0	0	1	1	1	0	3	3	3	3	3	3	0	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr3:194991445G>A	uc003fum.3	-	1	451	c.343C>T	c.(343-345)CAG>TAG	p.Q115*		NM_152531	NP_689744	Q8NBI6	CC021_HUMAN	hypothetical protein LOC152002	115						integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)		GCCTTGGCCTGCAGCGCGGCA	0.687													10	22					0	0	0	0	A	194991445	A	A	194991445	4	1	246	1	0	0	0	0	0	1	0	0	2224	1328	46	4	854	4	C3orf21	3	194991445	Nonsense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	628477	194991445	3030985	55	45118											
ADRA2C	152	broad.mit.edu	37	chr4	3768899	3768899	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctccttcccgccgctggtctCgctctaccgccagcccgacg	3	8	9	21	6	2	0	0	0	2	0	5	1	4	0	6	1	2	2	6	1	1	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr4:3768899C>G	uc003ghm.2	+	1	604	c.566C>G	c.(565-567)TCG>TGG	p.S189W	ADRA2C_uc010icx.2_Missense_Mutation_p.S189W	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	189	Helical; Name=4; (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CCGCTGGTCTCGCTCTACCGC	0.677													3	4					0	0	0	0	G	3768899	G	G	3768899	3	3	246	1	0	0	0	0	1	0	0	0	339	893	31	3	568	3	ADRA2C	4	3768899	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08		3768899	187385377	56	45119											
CLOCK	9575	broad.mit.edu	37	chr4	56310930	56310930	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctttcagatgttgcatggctCctaattgagctgaaaactga	11	13	9	8	0	1	4	1	3	0	1	2	4	2	4	1	1	3	4	1	1	3	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr4:56310930C>A	uc003haz.1	-	20	2488	c.1562G>T	c.(1561-1563)GGA>GTA	p.G521V	CLOCK_uc003hba.1_Missense_Mutation_p.G521V|CLOCK_uc010igu.1_RNA	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	521	Implicated in the circadian rhythmicity (By similarity).				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			TTGCATGGCTCCTAATTGAGC	0.338													19	24					6.49762e-13	6.93079e-13	1	0	A	56310930	A	A	56310930	3	1	246	1	0	0	0	0	1	0	0	0	3564	855	30	2	998	2	CLOCK	4	56310930	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	52542031	56310930	134843346	57	45120											
SLC4A4	8671	broad.mit.edu	37	chr4	72397811	72397811	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcagtgattttgccattatCttgtccattctcatcttttg	7	20	5	9	0	4	1	2	1	3	0	6	1	5	1	2	0	1	0	2	0	1	7			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr4:72397811C>T	uc003hfy.2	+	17	2316	c.2199C>T	c.(2197-2199)ATC>ATT	p.I733I	SLC4A4_uc010iic.2_Silent_p.I733I|SLC4A4_uc010iib.2_Silent_p.I733I|SLC4A4_uc003hfz.2_Silent_p.I733I|SLC4A4_uc003hgc.3_Silent_p.I689I|SLC4A4_uc010iid.2_5'UTR	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	733	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TTGCCATTATCTTGTCCATTC	0.378													13	38					0	0	0	0	T	72397811	T	T	72397811	2	4	246	1	0	0	0	0	0	0	0	1	14720	903	32	2		2	SLC4A4	4	72397811	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	16086881	72397811	118756465	58	45121											
TIGD2	166815	broad.mit.edu	37	chr4	90034531	90034531	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttaagcagcgccatggtattCcaaaggctgctggtaaagga	12	9	12	8	1	0	0	0	0	0	0	1	1	1	1	2	4	3	5	2	4	5	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr4:90034531C>G	uc003hsk.2	+	1	564	c.406C>G	c.(406-408)CCA>GCA	p.P136A	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	136	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		Ccatggtattccaaaggctgc	0.194													20	46					0	0	0	0	G	90034531	G	G	90034531	3	3	246	1	0	0	0	0	1	0	0	0	15962	855	30	2	408	2	TIGD2	4	90034531	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	17636720	90034531	101119745	59	45122											
FGG	2266	broad.mit.edu	37	chr4	155530881	155530881	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaataaagtaaagcccgctCtgtttagctcccttattggc	10	14	7	10	1	1	0	0	0	1	0	2	0	2	0	2	1	2	4	2	1	7	7			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr4:155530881C>T	uc003ioj.2	-	6	708	c.567G>A	c.(565-567)CAG>CAA	p.Q189Q	FGG_uc003iog.2_Silent_p.Q189Q|FGG_uc003ioh.2_Silent_p.Q197Q|FGG_uc010ipx.2_Silent_p.Q17Q|FGG_uc010ipy.2_5'UTR|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Silent_p.Q197Q	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	189	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AAAGCCCGCTCTGTTTAGCTC	0.418													17	57					0	0	0	0	T	155530881	T	T	155530881	2	4	246	1	0	0	0	0	0	0	0	1	5902	912	32	2		2	FGG	4	155530881	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	65496350	155530881	35623395	60	45123											
TRIO	7204	broad.mit.edu	37	chr5	14368963	14368963	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcaagatggaagatcgcctCaagctcgtcaacgcctctgt	10	9	9	13	3	4	2	3	0	1	2	6	3	4	3	2	1	2	1	2	1	4	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:14368963C>G	uc003jff.2	+	17	3027	c.3021C>G	c.(3019-3021)CTC>CTG	p.L1007L	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.L958L|TRIO_uc003jfh.1_Silent_p.L656L	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1007					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AAGATCGCCTCAAGCTCGTCA	0.522													10	68					0	0	0	0	G	14368963	G	G	14368963	2	3	246	1	0	0	0	0	0	0	0	1	16619	813	29	2		2	TRIO	5	14368963	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08		14368963	166546297	61	45124											
PDZD2	23037	broad.mit.edu	37	chr5	32088427	32088427	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccacccaggctgccatctgtCctgcctcagccaaagttctg	7	9	8	17	0	3	0	1	0	2	0	4	0	4	0	6	1	3	2	6	1	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:32088427C>G	uc003jhl.2	+	20	5261	c.4873C>G	c.(4873-4875)CCT>GCT	p.P1625A	PDZD2_uc003jhm.2_Missense_Mutation_p.P1625A	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1625					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						TGCCATCTGTCCTGCCTCAGC	0.557													54	124					0	0	0	0	G	32088427	G	G	32088427	3	3	246	1	0	0	0	0	1	0	0	0	11755	855	30	2	4947	2	PDZD2	5	32088427	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	17719464	32088427	148826833	62	45125											
HCN1	348980	broad.mit.edu	37	chr5	45353208	45353208	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaataaatcttacctctctCagaggatcattgagttcatt	13	14	5	9	0	5	2	3	1	2	1	6	3	5	3	1	1	1	1	1	1	4	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:45353208C>T	uc003jok.2	-	5	1396	c.1371G>A	c.(1369-1371)CTG>CTA	p.L457L		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	457	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTACCTCTCTCAGAGGATCAT	0.343													13	32					0	0	0	0	T	45353208	T	T	45353208	2	4	246	1	0	0	0	0	0	0	0	1	7035	813	29	2		2	HCN1	5	45353208	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	13264781	45353208	135562052	63	45126											
MAP1B	4131	broad.mit.edu	37	chr5	71494584	71494584	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttatattcacctactttttCagattctacctctgcagtca	9	18	3	11	0	5	1	3	0	2	1	5	1	5	1	2	0	3	1	2	0	4	9			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:71494584C>T	uc003kbw.3	+	5	5643	c.5402C>T	c.(5401-5403)TCA>TTA	p.S1801L	MAP1B_uc010iyw.1_Missense_Mutation_p.S1818L|MAP1B_uc010iyx.1_Missense_Mutation_p.S1675L|MAP1B_uc010iyy.1_Missense_Mutation_p.S1675L	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1801						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CCTACTTTTTCAGATTCTACC	0.473													13	63					0	0	0	0	T	71494584	T	T	71494584	3	4	246	1	0	0	0	0	1	0	0	0	9281	838	29	2	5420	2	MAP1B	5	71494584	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	26141376	71494584	109420676	64	45127											
ENC1	8507	broad.mit.edu	37	chr5	73931590	73931590	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgagatagatggctggcaGaagtgccagccttactgtct	10	10	12	9	0	1	3	0	1	1	3	1	4	1	3	2	2	3	2	2	2	3	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:73931590G>C	uc003kdc.3	-	2	1852	c.721C>G	c.(721-723)CTG>GTG	p.L241V	ENC1_uc011css.1_Missense_Mutation_p.L168V	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	241					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		ATGGCTGGCAGAAGTGCCAGC	0.483													22	65					0	0	0	0	C	73931590	C	C	73931590	3	2	246	1	0	0	0	0	1	0	0	0	5137	933	33	2	1052	2	ENC1	5	73931590	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	2437006	73931590	106983670	65	45128											
ANKRD34B	340120	broad.mit.edu	37	chr5	79855801	79855801	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatggactgctttgatcaagGaatttccttcacttgaaatt	11	15	8	7	0	2	2	2	2	0	0	3	5	3	4	1	2	1	1	1	2	3	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:79855801G>T	uc010jam.2	-	4	388	c.38C>A	c.(37-39)TCC>TAC	p.S13Y	ANKRD34B_uc003kgw.2_Missense_Mutation_p.S13Y|ANKRD34B_uc010jan.2_Missense_Mutation_p.S13Y	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	13	ANK 1.					cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		TTTGATCAAGGAATTTCCTTC	0.458													15	58					1.5739e-10	1.66495e-10	1	0	T	79855801	T	T	79855801	3	4	246	1	0	0	0	0	1	0	0	0	663	1174	41	2	1510	2	ANKRD34B	5	79855801	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	5924211	79855801	101059459	66	45129											
XRCC4	7518	broad.mit.edu	37	chr5	82491695	82491695	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcagaaaatcaagccaaaaAtgagcacctgcagaaagaaa	21	4	8	8	0	1	4	1	1	0	3	1	4	1	4	2	0	4	3	2	0	7	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:82491695A>C	uc003kib.2	+	4	550	c.422A>C	c.(421-423)AAT>ACT	p.N141T	XRCC4_uc003kia.1_Missense_Mutation_p.N141T|XRCC4_uc003kid.2_Missense_Mutation_p.N141T|XRCC4_uc003kic.2_Missense_Mutation_p.N141T|XRCC4_uc003kie.2_Missense_Mutation_p.N141T|XRCC4_uc003kif.1_Missense_Mutation_p.N141T	NM_022406	NP_071801	Q13426	XRCC4_HUMAN	X-ray repair cross complementing protein 4	141	Potential.				DNA ligation involved in DNA repair|double-strand break repair via nonhomologous end joining|initiation of viral infection|positive regulation of ligase activity|provirus integration|response to X-ray	cytosol|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|nucleoplasm	DNA binding|protein C-terminus binding			skin(3)	3		Lung NSC(167;0.00132)|all_lung(232;0.00154)|Ovarian(174;0.034)		OV - Ovarian serous cystadenocarcinoma(54;1.44e-38)|Epithelial(54;3.72e-33)|all cancers(79;9.22e-28)		CAAGCCAAAAATGAGCACCTG	0.403								NHEJ					10	72					0	0	0	0	C	82491695	C	C	82491695	3	2	246	1	0	0	0	0	1	0	0	0	17523	101	4	5	432	5	XRCC4	5	82491695	Missense_Mutation	SNP	A	TCGA-CV-7406-01A-11D-2078-08	2635894	82491695	98423565	67	45130											
GPR98	84059	broad.mit.edu	37	chr5	89943367	89943367	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgccaactttacagttctCagaaatggatctgttgatgt	11	14	8	8	0	2	2	1	1	2	1	3	3	2	3	1	1	3	2	1	1	3	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:89943367C>T	uc003kju.2	+	17	3171	c.3075C>T	c.(3073-3075)CTC>CTT	p.L1025L	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1025	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTACAGTTCTCAGAAATGGAT	0.433													20	40					0	0	0	0	T	89943367	T	T	89943367	2	4	246	1	0	0	0	0	0	0	0	1	6760	813	29	2		2	GPR98	5	89943367	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	7451672	89943367	90971893	68	45131											
TTC37	9652	broad.mit.edu	37	chr5	94876457	94876457	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggaactgagtcaattttctCcatagttgatgaagctcttc	11	14	8	8	0	3	3	1	3	2	0	5	4	3	4	1	1	2	2	1	1	4	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:94876457C>T	uc003klb.2	-	8	750	c.480G>A	c.(478-480)TGG>TGA	p.W160*	TTC37_uc010jbf.1_Nonsense_Mutation_p.W112*	NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	160							binding			ovary(3)|pancreas(1)	4						TCAATTTTCTCCATAGTTGAT	0.378													27	65					0	0	0	0	T	94876457	T	T	94876457	4	4	246	1	0	0	0	0	0	1	0	0	16773	856	30	2	4358	2	TTC37	5	94876457	Nonsense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	4933090	94876457	86038803	69	45132											
RAD50	10111	broad.mit.edu	37	chr5	131915735	131915735	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaaattgtcaaatcctatGagaatgaacttgatccattg	15	12	8	6	0	1	3	1	3	0	1	3	5	3	4	2	1	1	0	2	1	5	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:131915735G>A	uc003kxi.2	+	5	1120	c.733G>A	c.(733-735)GAG>AAG	p.E245K	RAD50_uc003kxg.1_Missense_Mutation_p.E146K|RAD50_uc003kxh.2_Missense_Mutation_p.E106K	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	245	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAAATCCTATGAGAATGAACT	0.229								Homologous_recombination					33	66					0	0	0	0	A	131915735	A	A	131915735	3	1	246	1	0	0	0	0	1	0	0	0	13049	1291	45	2	751	2	RAD50	5	131915735	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	37039278	131915735	48999525	70	45133											
EGR1	1958	broad.mit.edu	37	chr5	137803417	137803417	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcagaaggacaagaaagcaGacaaaagtgttgtggcctct	15	6	13	7	0	1	3	0	0	1	3	1	4	1	4	1	3	1	3	1	3	5	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:137803417G>A	uc003ldb.1	+	2	1549	c.1279G>A	c.(1279-1281)GAC>AAC	p.D427N	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	427					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CAAGAAAGCAGACAAAAGTGT	0.323													12	32					0	0	0	0	A	137803417	A	A	137803417	3	1	246	1	0	0	0	0	1	0	0	0	4993	942	33	2	1285	2	EGR1	5	137803417	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	5887682	137803417	43111843	71	45134											
PSD2	84249	broad.mit.edu	37	chr5	139192996	139192996	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcacccagtacagcagcctCgactccctagacgggctgag	9	5	12	15	2	0	2	0	1	0	1	2	3	1	2	3	2	3	4	3	2	2	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:139192996C>T	uc003leu.1	+	3	679	c.474C>T	c.(472-474)CTC>CTT	p.L158L		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	158					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGCAGCCTCGACTCCCTAG	0.652													27	59					0	0	0	0	T	139192996	T	T	139192996	2	4	246	1	0	0	0	0	0	0	0	1	12709	871	31	1		1	PSD2	5	139192996	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	1389579	139192996	41722264	72	45135											
PCDHGA4	56111	broad.mit.edu	37	chr5	140735361	140735361	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagagctggtgctggaacgCgctctagatcgcgaggaaga	10	6	15	10	4	1	3	0	0	1	3	2	6	1	5	1	3	3	3	1	3	3	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:140735361C>T	uc003ljq.1	+	1	594	c.594C>T	c.(592-594)CGC>CGT	p.R198R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.R198R	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	198	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTGGAACGCGCTCTAGATC	0.567													7	8					0	0	0	0	T	140735361	T	T	140735361	2	4	246	1	0	0	0	0	0	0	0	1	11610	755	27	1		1	PCDHGA4	5	140735361	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	1542365	140735361	40179899	73	45136											
PCDHGA12	26025	broad.mit.edu	37	chr5	140811312	140811312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggataatgcaggatattctgCgcgagccaaagtcctgatca	12	9	11	9	2	2	1	1	1	1	0	3	4	3	3	2	2	3	1	2	2	3	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:140811312C>T	uc003lkt.1	+	1	1155	c.986C>T	c.(985-987)GCG>GTG	p.A329V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.A329V	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	329	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATATTCTGCGCGAGCCAAA	0.507													23	55					0	0	0	0	T	140811312	T	T	140811312	3	4	246	1	0	0	0	0	1	0	0	0	11607	768	27	1	988	1	PCDHGA12	5	140811312	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	75951	140811312	40103948	74	45137											
SPRY4	81848	broad.mit.edu	37	chr5	141694650	141694650	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagttgggagtcaagggggcGctctgtgggatcgggggctc	5	8	21	7	2	2	0	1	0	1	0	4	3	2	2	0	6	0	3	0	6	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:141694650G>A	uc003lml.2	-	2	283	c.24C>T	c.(22-24)AGC>AGT	p.S8S	SPRY4_uc010jgi.1_Silent_p.S31S	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	8					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAAGGGGGCGCTCTGTGGGA	0.632									Testicular_Cancer_Familial_Clustering_of				10	21					0	0	0	0	A	141694650	A	A	141694650	2	1	246	1	0	0	0	0	0	0	0	1	15174	1078	38	1		1	SPRY4	5	141694650	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	883338	141694650	39220610	75	45138											
EBF1	1879	broad.mit.edu	37	chr5	158140039	158140039	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttgtccactgaacgaattCacgcccatcatccctgcgtg	9	10	8	14	3	2	1	2	1	0	0	4	2	4	1	3	0	2	1	3	0	2	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:158140039C>T	uc010jip.2	-	13	1610	c.1308G>A	c.(1306-1308)GTG>GTA	p.V436V	EBF1_uc011ddw.1_Silent_p.V304V|EBF1_uc011ddx.1_Silent_p.V437V|EBF1_uc003lxl.3_Silent_p.V405V	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	436					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGAACGAATTCACGCCCATCA	0.577			T	HMGA2	lipoma								22	45					0	0	0	0	T	158140039	T	T	158140039	2	4	246	1	0	0	0	0	0	0	0	1	4902	813	29	2		2	EBF1	5	158140039	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	16445389	158140039	22775221	76	45139											
ODZ2	57451	broad.mit.edu	37	chr5	167645222	167645222	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcatccttcgaatcaccgaGaaccaccaagtcagcatcat	13	8	6	14	2	4	1	4	0	0	1	6	3	5	1	4	0	2	1	4	0	3	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr5:167645222G>A	uc010jjd.2	+	23	4299	c.4299G>A	c.(4297-4299)GAG>GAA	p.E1433E	ODZ2_uc003lzr.3_Silent_p.E1203E|ODZ2_uc003lzt.3_Silent_p.E806E|ODZ2_uc010jje.2_Silent_p.E697E	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GAATCACCGAGAACCACCAAG	0.507													43	110					0	0	0	0	A	167645222	A	A	167645222	2	1	246	1	0	0	0	0	0	0	0	1	10889	933	33	2		2	ODZ2	5	167645222	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	9505183	167645222	13270038	77	45140											
SERPINB1	1992	broad.mit.edu	37	chr6	2838863	2838863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgctccacgtttgttgatatCagcattcagactctggaatc	9	13	8	11	2	3	2	2	1	1	1	5	3	4	3	1	1	1	4	1	1	2	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:2838863C>T	uc003mub.2	-	3	270	c.226G>A	c.(226-228)GAT>AAT	p.D76N	SERPINB1_uc003muc.2_5'UTR	NM_030666	NP_109591	P30740	ILEU_HUMAN	serine (or cysteine) proteinase inhibitor, clade	76					regulation of proteolysis	cytoplasm|extracellular space	serine-type endopeptidase inhibitor activity			breast(4)|ovary(1)	5	Ovarian(93;0.0412)			OV - Ovarian serous cystadenocarcinoma(45;0.0717)		TTGTTGATATCAGCATTCAGA	0.338													12	38					0	0	0	0	T	2838863	T	T	2838863	3	4	246	1	0	0	0	0	1	0	0	0	14161	826	29	2	933	2	SERPINB1	6	2838863	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08		2838863	168276204	78	45141											
ZNF184	7738	broad.mit.edu	37	chr6	27419348	27419348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagggcttctccccagtgtGaattcgttgatgctgagtta	8	14	11	8	1	1	3	0	3	1	0	3	3	1	3	2	1	1	4	2	1	3	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:27419348G>A	uc003njj.2	-	5	2801	c.1990C>T	c.(1990-1992)CAC>TAC	p.H664Y	ZNF184_uc010jqv.2_Missense_Mutation_p.H664Y|ZNF184_uc003nji.2_Missense_Mutation_p.H664Y	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	664	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCCCCAGTGTGAATTCGTTGA	0.423													24	45					0	0	0	0	A	27419348	A	A	27419348	3	1	246	1	0	0	0	0	1	0	0	0	17818	1290	45	2	269	2	ZNF184	6	27419348	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	24580485	27419348	143695719	79	45142											
ZNF184	7738	broad.mit.edu	37	chr6	27419878	27419878	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccgatgttgagtaagggatGagcagtaactgaaggccttt	11	11	13	6	1	0	3	0	3	0	0	1	5	1	4	2	2	2	4	2	2	3	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:27419878G>A	uc003njj.2	-	5	2271	c.1460C>T	c.(1459-1461)TCA>TTA	p.S487L	ZNF184_uc010jqv.2_Missense_Mutation_p.S487L|ZNF184_uc003nji.2_Missense_Mutation_p.S487L	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	487	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGTAAGGGATGAGCAGTAACT	0.403													25	59					0	0	0	0	A	27419878	A	A	27419878	3	1	246	1	0	0	0	0	1	0	0	0	17818	1294	45	2	799	2	ZNF184	6	27419878	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	530	27419878	143695189	80	45143											
GNL1	2794	broad.mit.edu	37	chr6	30521243	30521243	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggcaaccacaagagctggcGgggccagatccaccttgttc	10	6	12	13	1	0	2	0	0	0	2	2	2	1	2	4	4	2	3	4	4	2	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:30521243G>A	uc003nqh.2	-	6	1720	c.692C>T	c.(691-693)CCG>CTG	p.P231L	GNL1_uc011dmi.1_Missense_Mutation_p.P93L|GNL1_uc011dmj.1_Missense_Mutation_p.P229L|GNL1_uc011dmk.1_Intron	NM_005275	NP_005266	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	231					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			ovary(3)	3						AAGAGCTGGCGGGGCCAGATC	0.542													30	82					0	0	0	0	A	30521243	A	A	30521243	3	1	246	1	0	0	0	0	1	0	0	0	6572	1116	39	1	1159	1	GNL1	6	30521243	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	3101365	30521243	140593824	81	45144											
SPDEF	25803	broad.mit.edu	37	chr6	34507128	34507128	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatgggctgcccggagcatGatgagtccacctcgctgtcg	6	8	15	12	3	0	2	0	2	0	0	3	4	1	4	3	3	2	3	3	3	0	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:34507128G>A	uc003ojq.1	-	5	1143	c.728C>T	c.(727-729)TCA>TTA	p.S243L	SPDEF_uc011dsq.1_Missense_Mutation_p.S227L	NM_012391	NP_036523	O95238	SPDEF_HUMAN	SAM pointed domain containing ets transcription	243					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(3)|ovary(1)|central_nervous_system(1)	5						CCCGGAGCATGATGAGTCCAC	0.622													42	126					0	0	0	0	A	34507128	A	A	34507128	3	1	246	1	0	0	0	0	1	0	0	0	15092	1294	45	2	287	2	SPDEF	6	34507128	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	3985885	34507128	136607939	82	45145											
FAM135A	57579	broad.mit.edu	37	chr6	71190648	71190648	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggttaaatagaaatgcacCagcacaaaacaaagattccg	18	8	7	8	1	0	2	0	0	0	2	1	2	1	2	2	1	3	3	2	1	7	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:71190648C>T	uc003pfj.2	+	7	720	c.587C>T	c.(586-588)CCA>CTA	p.P196L	FAM135A_uc003pfi.2_Missense_Mutation_p.P196L|FAM135A_uc003pfh.2_Missense_Mutation_p.P153L|FAM135A_uc003pfk.2_Missense_Mutation_p.P196L|FAM135A_uc003pfl.2_Missense_Mutation_p.P33L|FAM135A_uc003pfm.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	196										central_nervous_system(1)	1						AGAAATGCACCAGCACAAAAC	0.358													14	37					0	0	0	0	T	71190648	T	T	71190648	3	4	246	1	0	0	0	0	1	0	0	0	5476	594	21	4	609	4	FAM135A	6	71190648	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	36683520	71190648	99924419	83	45146											
HACE1	57531	broad.mit.edu	37	chr6	105224986	105224986	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctactcctaaaaatagaatCtaaatatgtagcattggtta	16	13	6	6	0	1	1	0	0	1	1	2	1	2	1	1	1	2	4	1	1	11	8			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:105224986C>G	uc003pqu.1	-	16	1956	c.1679_splice	c.e16-1	p.D560_splice	HACE1_uc010kcy.1_Splice_Site_p.D42_splice|HACE1_uc010kcz.1_Intron|HACE1_uc010kcx.1_Intron|HACE1_uc003pqt.1_Splice_Site_p.D213_splice	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		AAAATAGAATCTAAATATGTA	0.328													10	15					0	0	0	0	G	105224986	G	G	105224986	5	3	246	1	0	0	0	0	0	0	1	0	6979	927	32	2	1087	2	HACE1	6	105224986	Splice_Site	SNP	C	TCGA-CV-7406-01A-11D-2078-08	34034338	105224986	65890081	84	45147											
LAMA4	3910	broad.mit.edu	37	chr6	112438963	112438963	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagaaccacgtatcctccttCtgttgaaaagtaagttcctg	11	13	7	10	1	1	2	0	1	1	1	4	2	4	2	4	0	1	4	4	0	6	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:112438963C>G	uc003pvu.2	-	35	5269	c.4960G>C	c.(4960-4962)GAA>CAA	p.E1654Q	LAMA4_uc003pvv.2_Missense_Mutation_p.E1647Q|LAMA4_uc003pvt.2_Missense_Mutation_p.E1647Q	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1654	Laminin G-like 5.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TATCCTCCTTCTGTTGAAAAG	0.458													33	94					0	0	0	0	G	112438963	G	G	112438963	3	3	246	1	0	0	0	0	1	0	0	0	8648	922	32	2	531	2	LAMA4	6	112438963	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	7213977	112438963	58676104	85	45148											
SYTL3	94120	broad.mit.edu	37	chr6	159129394	159129394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctactccacctcctgtcagcGagagccagtgcagccgcagt	8	7	10	16	2	1	1	1	0	0	1	3	2	3	1	5	0	5	2	5	0	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr6:159129394G>A	uc003qrp.2	+	7	731	c.487G>A	c.(487-489)GAG>AAG	p.E163K	SYTL3_uc011efp.1_Missense_Mutation_p.E163K|SYTL3_uc003qro.2_Missense_Mutation_p.E163K|SYTL3_uc003qrq.2_Missense_Mutation_p.E163K|SYTL3_uc003qrr.2_Missense_Mutation_p.E163K|SYTL3_uc003qrs.2_Missense_Mutation_p.E163K|SYTL3_uc011efq.1_Intron	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	163					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TCCTGTCAGCGAGAGCCAGTG	0.517													18	45					0	0	0	0	A	159129394	A	A	159129394	3	1	246	1	0	0	0	0	1	0	0	0	15550	1059	37	1	505	1	SYTL3	6	159129394	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	46690431	159129394	11985673	86	45149											
HECW1	23072	broad.mit.edu	37	chr7	43483921	43483921	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtggggaacctcggtctgagGcaccagagtcctctgagagc	8	7	15	11	1	2	3	0	2	2	2	4	5	3	4	3	4	2	1	3	4	1	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:43483921G>A	uc003tid.1	+	11	1755	c.1150G>A	c.(1150-1152)GCA>ACA	p.A384T	HECW1_uc011kbi.1_Missense_Mutation_p.A384T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	384					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TCGGTCTGAGGCACCAGAGTC	0.577													17	29					0	0	0	0	A	43483921	A	A	43483921	3	1	246	1	0	0	0	0	1	0	0	0	7081	1203	42	4	1184	4	HECW1	7	43483921	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08		43483921	115654742	87	45150											
ADCY1	107	broad.mit.edu	37	chr7	45753517	45753517	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgtgccccatgcctggcGtctcagtcagggctgggctc	3	9	14	15	2	2	0	2	0	1	0	4	0	2	0	4	3	2	2	4	3	0	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:45753517G>A	uc003tne.3	+	20	3301	c.3283G>A	c.(3283-3285)GTC>ATC	p.V1095I		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	1095	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CATGCCTGGCGTCTCAGTCAG	0.652													19	57					0	0	0	0	A	45753517	A	A	45753517	3	1	246	1	0	0	0	0	1	0	0	0	292	1145	40	1	3361	1	ADCY1	7	45753517	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	2269596	45753517	113385146	88	45151											
COBL	23242	broad.mit.edu	37	chr7	51096125	51096125	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ataacccttctcggcataacCgtgtggcctcaccacatcag	10	9	7	15	2	3	0	2	0	1	0	4	0	3	0	4	2	2	1	4	2	2	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:51096125C>T	uc003tpr.3	-	10	2853	c.2668G>A	c.(2668-2670)GGT>AGT	p.G890S	COBL_uc003tps.2_Missense_Mutation_p.G947S|COBL_uc011kcl.1_Missense_Mutation_p.G890S|COBL_uc003tpp.3_Missense_Mutation_p.G676S|COBL_uc003tpq.3_Missense_Mutation_p.G831S|COBL_uc003tpo.3_Missense_Mutation_p.G432S	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	890										skin(3)|ovary(2)	5	Glioma(55;0.08)					TCGGCATAACCGTGTGGCCTC	0.562													17	54					0	0	0	0	T	51096125	T	T	51096125	3	4	246	1	0	0	0	0	1	0	0	0	3668	652	23	1	1133	1	COBL	7	51096125	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	5342608	51096125	108042538	89	45152											
ZNF716	441234	broad.mit.edu	37	chr7	57529035	57529035	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttactaactacaagagaattCatactggagagaaaccctac	17	9	6	9	0	1	2	1	0	0	2	1	5	1	3	1	1	6	0	1	1	8	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:57529035C>T	uc011kdi.1	+	4	980	c.868C>T	c.(868-870)CAT>TAT	p.H290Y		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						CAAGAGAATTCATACTGGAGA	0.408													9	17					0	0	0	0	T	57529035	T	T	57529035	3	4	246	1	0	0	0	0	1	0	0	0	18186	826	29	2	882	2	ZNF716	7	57529035	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	6432910	57529035	101609628	90	45153											
HGF	3082	broad.mit.edu	37	chr7	81374353	81374353	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgccggtgtggtgtctgatGatcccagcgctgacaaatct	7	11	13	10	2	2	3	0	3	2	0	3	3	3	3	2	2	2	1	2	2	1	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:81374353G>A	uc003uhl.2	-	6	874	c.709C>T	c.(709-711)CAT>TAT	p.H237Y	HGF_uc003uhm.2_Missense_Mutation_p.H232Y|HGF_uc003uhn.1_Missense_Mutation_p.H237Y|HGF_uc003uho.1_Missense_Mutation_p.H232Y	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	237	Kringle 2.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						GGTGTCTGATGATCCCAGCGC	0.378													16	39					0	0	0	0	A	81374353	A	A	81374353	3	1	246	1	0	0	0	0	1	0	0	0	7124	1290	45	2	1541	2	HGF	7	81374353	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	23845318	81374353	77764310	91	45154											
PEX1	5189	broad.mit.edu	37	chr7	92131331	92131331	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcaggtcaagatcggtgaaCttgtttatatcacagtccaa	12	12	9	8	1	2	2	2	1	0	1	4	2	3	2	1	2	2	2	1	2	5	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:92131331C>G	uc003uly.2	-	14	2385	c.2289G>C	c.(2287-2289)AAG>AAC	p.K763N	PEX1_uc011khr.1_Missense_Mutation_p.K555N|PEX1_uc010ley.2_Missense_Mutation_p.K706N|PEX1_uc011khs.1_Missense_Mutation_p.K441N|PEX1_uc011kht.1_Intron	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	763					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GATCGGTGAACTTGTTTATAT	0.353													58	170					0	0	0	0	G	92131331	G	G	92131331	3	3	246	1	0	0	0	0	1	0	0	0	11790	564	20	4	1606	4	PEX1	7	92131331	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	10756978	92131331	67007332	92	45155											
AP4M1	9179	broad.mit.edu	37	chr7	99704400	99704400	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cggcacacgtgctctggcctCcaggtccgattcctcaggct	5	9	11	16	3	2	0	1	0	1	0	5	1	5	0	4	4	1	3	4	4	0	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:99704400C>G	uc003utb.3	+	15	1465	c.1257C>G	c.(1255-1257)CTC>CTG	p.L419L	AP4M1_uc010lgl.1_Silent_p.L394L|AP4M1_uc003utc.3_Silent_p.L426L|AP4M1_uc010lgm.2_Silent_p.L291L|AP4M1_uc003utd.2_Silent_p.L419L|AP4M1_uc011kjh.1_Silent_p.L371L|AP4M1_uc003ute.3_Silent_p.L194L|AP4M1_uc003utf.3_Silent_p.L291L	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	419	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCTCTGGCCTCCAGGTCCGAT	0.652													9	55					0	0	0	0	G	99704400	G	G	99704400	2	3	246	1	0	0	0	0	0	0	0	1	753	842	30	2		2	AP4M1	7	99704400	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	7573069	99704400	59434263	93	45156											
RELN	5649	broad.mit.edu	37	chr7	103294652	103294652	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttccagggtcacaaattcctCctgcacaaaacaaaaatttt	15	11	4	11	0	1	0	1	0	0	0	4	0	4	0	3	1	2	1	3	1	5	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:103294652C>G	uc003vca.2	-	13	1602	c.1442G>C	c.(1441-1443)GGA>GCA	p.G481A	RELN_uc010liz.2_Missense_Mutation_p.G481A	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	481					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACAAATTCCTCCTGCACAAAA	0.318													11	34					0	0	0	0	G	103294652	G	G	103294652	3	3	246	1	0	0	0	0	1	0	0	0	13285	869	30	2	9152	2	RELN	7	103294652	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	3590252	103294652	55844011	94	45157											
TMEM168	64418	broad.mit.edu	37	chr7	112412901	112412901	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaaaatatacgtatcatgtCtgggtccatccactgtccga	12	11	7	11	2	2	0	1	0	1	0	5	1	5	0	3	1	1	1	3	1	5	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:112412901C>G	uc003vgn.2	-	4	1873	c.1481G>C	c.(1480-1482)AGA>ACA	p.R494T	TMEM168_uc010lju.2_Missense_Mutation_p.R494T|TMEM168_uc011kmr.1_Missense_Mutation_p.R110T	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	494						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						CGTATCATGTCTGGGTCCATC	0.443													21	51					0	0	0	0	G	112412901	G	G	112412901	3	3	246	1	0	0	0	0	1	0	0	0	16149	913	32	2	620	2	TMEM168	7	112412901	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	9118249	112412901	46725762	95	45158											
FEZF1	389549	broad.mit.edu	37	chr7	121944204	121944205	+	Missense_Mutation	DNP	CC	TT	TT																															ggggcctccagactggccttCcgcggctcggagcccgtcac																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:121944204_121944205CC>TT	uc003vkd.2	-	1	361_362	c.287_288GG>AA	c.(286-288)CGG>CAA	p.R96Q	FEZF1_uc003vkc.2_Missense_Mutation_p.R96Q|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	96					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						GACTGGCCTTCCGCGGCTCGGA	0.569													6	13					0	0	0	0	TT	121944205	TT	TT	121944204	3	4	246	1	0	0	0	0	1	0	0	0	5857	842	30	2	1155	2	FEZF1	7	121944204	Missense_Mutation	DNP	CC	TCGA-CV-7406-01A-11D-2078-08	9531303	121944204	37194459	96	45159											
FLNC	2318	broad.mit.edu	37	chr7	128483349	128483349	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgccagcaaagtcaaggccGagggccctgggctgaatcgc	10	5	14	12	2	1	1	1	1	0	0	2	2	1	1	3	3	2	2	3	3	3	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:128483349G>A	uc003vnz.3	+	17	2826	c.2617G>A	c.(2617-2619)GAG>AAG	p.E873K	FLNC_uc003voa.3_Missense_Mutation_p.E873K	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	873	Filamin 7.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AGTCAAGGCCGAGGGCCCTGG	0.642													4	9					0	0	0	0	A	128483349	A	A	128483349	3	1	246	1	0	0	0	0	1	0	0	0	5967	1059	37	1	2683	1	FLNC	7	128483349	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	6539145	128483349	30655314	97	45160											
FLNC	2318	broad.mit.edu	37	chr7	128490905	128490907	+	In_Frame_Del	DEL	ACA	-	-																															ggcacggcccaacatcaccgAcaacaaggacggcaccatca																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:128490905_128490907delACA	uc003vnz.3	+	33	5656_5658	c.5447_5449delACA	c.(5446-5451)GACAAC>GAC	p.N1817del	FLNC_uc003voa.3_In_Frame_Del_p.N1784del	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1817	Filamin 16.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AACATCACCGACAACAAGGACGG	0.596													---	---	---								-	128490907	-	-	128490905	7	5	246	1	0	1	0	1	0	0	0	0	5967	275	10	0	5577	0	FLNC	7	128490905	In_Frame_Del	DEL	ACA	TCGA-CV-7406-01A-11D-2078-08	7556	128490905	30647758	98	45161											
KLF14	136259	broad.mit.edu	37	chr7	130417929	130417929	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgggcgccgggccgggaccgGagccggaggcggagctttcc	4	4	20	13	6	0	0	0	0	0	0	1	4	1	4	5	7	2	1	5	7	0	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:130417929G>A	uc003vqk.1	-	1	932	c.932C>T	c.(931-933)TCC>TTC	p.S311F		NM_138693	NP_619638	Q8TD94	KLF14_HUMAN	Kruppel-like factor 14	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(18;0.0435)					GCCGGGACCGGAGCCGGAGGC	0.627													3	14					0	0	0	0	A	130417929	A	A	130417929	3	1	246	1	0	0	0	0	1	0	0	0	8381	1174	41	2	43	2	KLF14	7	130417929	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1927024	130417929	28720734	99	45162											
EPHA1	2041	broad.mit.edu	37	chr7	143090949	143090949	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggtacccatcctcaatgctCttcataacctgcacggcggg	8	9	9	15	3	3	0	2	0	1	0	4	0	4	0	3	3	4	3	3	3	3	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr7:143090949C>G	uc003wcz.2	-	16	2598	c.2511G>C	c.(2509-2511)AAG>AAC	p.K837N		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	837	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CCTCAATGCTCTTCATAACCT	0.577													23	43					0	0	0	0	G	143090949	G	G	143090949	3	3	246	1	0	0	0	0	1	0	0	0	5189	912	32	2	431	2	EPHA1	7	143090949	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	12673020	143090949	16047714	100	45163											
ARHGEF10	9639	broad.mit.edu	37	chr8	1905058	1905067	+	Frame_Shift_Del	DEL	GCACTTCCGA	-	-																															aggacgaagaccagaaggacGcacttccgagtggaggagct																								rs145146038	byFrequency	TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:1905058_1905067delGCACTTCCGA	uc003wpr.2	+	29	3842_3851	c.3664_3673delGCACTTCCGA	c.(3664-3675)GCACTTCCGAGTfs	p.A1222fs	ARHGEF10_uc003wps.2_Frame_Shift_Del_p.A1184fs|ARHGEF10_uc010lre.2_Frame_Shift_Del_p.A873fs	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	1247_1250					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CCAGAAGGACGCACTTCCGAGTGGAGGAGC	0.59													---	---	---								-	1905067	-	-	1905058	7	5	246	1	0	1	0	1	0	0	0	0	894	1087	38	0	3774	0	ARHGEF10	8	1905058	Frame_Shift_Del	DEL	GCACTTCCGA	TCGA-CV-7406-01A-11D-2078-08		1905058	144458964	101	45164											
SNTG1	54212	broad.mit.edu	37	chr8	51621528	51621528	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggatttatctgctttgatgCtgcaacaaaggtaatgtgtt	11	15	10	5	0	1	1	0	1	1	0	1	2	1	2	0	2	4	5	0	2	4	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:51621528C>T	uc010lxy.1	+	18	1645	c.1274C>T	c.(1273-1275)GCT>GTT	p.A425V	SNTG1_uc003xqs.1_Missense_Mutation_p.A425V|SNTG1_uc010lxz.1_Missense_Mutation_p.A425V|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	425					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TGCTTTGATGCTGCAACAAAG	0.378													18	42					0	0	0	0	T	51621528	T	T	51621528	3	4	246	1	0	0	0	0	1	0	0	0	14938	797	28	4	1332	4	SNTG1	8	51621528	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	49716470	51621528	94742494	102	45165											
TRIM55	84675	broad.mit.edu	37	chr8	67066571	67066571	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctgcagctacttctcaggTtagtgatgatgcacttgtgt	8	14	10	9	0	1	2	1	2	1	0	2	2	1	2	1	1	4	4	1	1	2	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:67066571T>G	uc003xvv.2	+	9	1750	c.1524_splice	c.e9+2	p.Q508_splice	TRIM55_uc003xvu.2_Splice_Site_p.Q508_splice|TRIM55_uc003xvw.2_Intron|TRIM55_uc003xvx.2_Intron	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1							cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			ACTTCTCAGGTTAGTGATGAT	0.542													10	27					0	0	0	0	G	67066571	G	G	67066571	5	3	246	1	0	0	0	0	0	0	1	0	16596	1739	60	5	1560	5	TRIM55	8	67066571	Splice_Site	SNP	T	TCGA-CV-7406-01A-11D-2078-08	15445043	67066571	79297451	103	45166											
NCOA2	10499	broad.mit.edu	37	chr8	71039096	71039096	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcatttgcctggggaatccGagggttgctcatagttgctg	6	13	14	8	1	1	0	1	0	0	0	2	2	2	1	2	3	4	5	2	3	2	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:71039096G>A	uc003xyn.1	-	19	4030	c.3868C>T	c.(3868-3870)CGG>TGG	p.R1290W	NCOA2_uc011lfb.1_Missense_Mutation_p.R378W	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1290					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TGGGGAATCCGAGGGTTGCTC	0.502			T	RUNXBP2	AML								4	23					0	0	0	0	A	71039096	A	A	71039096	3	1	246	1	0	0	0	0	1	0	0	0	10283	1057	37	1	546	1	NCOA2	8	71039096	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	3972525	71039096	75324926	104	45167											
CNBD1	168975	broad.mit.edu	37	chr8	88363940	88363940	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaagtggaaatataatttCttttgtgggttatattaact	13	17	9	2	0	1	0	0	0	1	0	1	2	1	2	0	3	1	1	0	3	7	8			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:88363940C>G	uc003ydy.2	+	9	1118	c.1070C>G	c.(1069-1071)TCT>TGT	p.S357C		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	357	cNMP.									ovary(3)	3						AATATAATTTCTTTTGTGGGT	0.274													3	7					0	0	0	0	G	88363940	G	G	88363940	3	3	246	1	0	0	0	0	1	0	0	0	3606	913	32	2	1104	2	CNBD1	8	88363940	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	17324844	88363940	58000082	105	45168											
CSMD3	114788	broad.mit.edu	37	chr8	113569178	113569178	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcttcacagtgtgagagttCaaaacctgggacaaaaatat	16	10	8	7	0	3	1	2	1	1	1	3	3	3	2	1	1	1	1	1	1	5	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:113569178C>T	uc003ynu.2	-	25	4207	c.4048G>A	c.(4048-4050)GAA>AAA	p.E1350K	CSMD3_uc003yns.2_Missense_Mutation_p.E622K|CSMD3_uc003ynt.2_Missense_Mutation_p.E1310K|CSMD3_uc011lhx.1_Missense_Mutation_p.E1246K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1350	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGTGAGAGTTCAAAACCTGGG	0.358										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	22					0	0	0	0	T	113569178	T	T	113569178	3	4	246	1	0	0	0	0	1	0	0	0	3963	835	29	2	7263	2	CSMD3	8	113569178	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	25205238	113569178	32794844	106	45169											
COL14A1	7373	broad.mit.edu	37	chr8	121354670	121354670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtggcgcgtcaagtatgcGaacagctcatccagagtaag	12	7	12	10	3	2	1	2	0	0	1	3	2	3	1	1	1	3	3	1	1	4	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:121354670G>A	uc003yox.2	+	44	5138	c.4873G>A	c.(4873-4875)GAA>AAA	p.E1625K	COL14A1_uc003yoz.2_Missense_Mutation_p.E590K	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1625					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCAAGTATGCGAACAGCTCAT	0.478													14	33					0	0	0	0	A	121354670	A	A	121354670	3	1	246	1	0	0	0	0	1	0	0	0	3686	1059	37	1	5043	1	COL14A1	8	121354670	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	7785492	121354670	25009352	107	45170											
GSDMC	56169	broad.mit.edu	37	chr8	130774940	130774941	+	Missense_Mutation	DNP	TT	GC	GC																															ctttctgaagagtcagcgccTtcttcttcactctgagactc																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:130774940_130774941TT>GC	uc003ysr.2	-	5	1489_1490	c.607_608AA>GC	c.(607-609)AAG>GCG	p.K203A		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	203						mitochondrion				ovary(2)|skin(1)	3						AGTCAGCGCCTTCTTCTTCACT	0.416													50	113					0	0	0	0	GC	130774941	GC	GC	130774940	3	3	246	1	0	0	0	0	1	0	0	0	6857	1609	56	5	958	5	GSDMC	8	130774940	Missense_Mutation	DNP	TT	TCGA-CV-7406-01A-11D-2078-08	9420270	130774940	15589082	108	45171											
ADCY8	114	broad.mit.edu	37	chr8	132052292	132052292	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctgtgcgctcgctctccCgggcccagcgagtagagggg	4	7	17	13	4	1	1	0	0	1	1	3	2	1	1	2	3	3	4	2	3	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-11A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	2ce728de-2f14-4346-95a2-8bf90bb2cde8	g.chr8:132052292C>T	uc003ytd.3	-	1	544	c.288G>A	c.(286-288)CCG>CCA	p.P96P	ADCY8_uc010mds.2_Silent_p.P96P	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	96	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTCGCTCTCCCGGGCCCAGCG	0.746										HNSCC(32;0.087)			3	8					0	0	0	0	T	132052292	T	T	132052292	2	4	246	1	0	0	0	0	0	0	0	1	300	639	23	1		1	ADCY8	8	132052292	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	1277352	132052292	14311730	109	45172											
ARC	23237	broad.mit.edu	37	chr8	143695106	143695106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcgccagcggctgggggcGgggtgatggcgtaggggctg	3	6	23	9	4	0	1	0	1	0	0	1	1	0	1	1	8	1	4	1	8	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:143695106G>A	uc003ywn.1	-	1	728	c.527C>T	c.(526-528)CCG>CTG	p.P176L		NM_015193	NP_056008	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated	176					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)	1	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				GGCTGGGGGCGGGGTGATGGC	0.746													5	4					0	0	0	0	A	143695106	A	A	143695106	3	1	246	1	0	0	0	0	1	0	0	0	841	1116	39	1	667	1	ARC	8	143695106	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	11642814	143695106	2668916	110	45173											
SHARPIN	81858	broad.mit.edu	37	chr8	145154328	145154328	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgggaaaccgagctctgaGaacacctgtggccagagcat	11	5	14	11	2	1	2	0	1	1	2	1	5	1	3	3	3	4	2	3	3	2	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:145154328G>A	uc003zba.2	-	6	1258	c.774C>T	c.(772-774)TTC>TTT	p.F258F	SHARPIN_uc003zbb.2_RNA	NM_030974	NP_112236	Q9H0F6	SHRPN_HUMAN	shank-interacting protein-like 1	258	Ubiquitin-like.|Interaction with SHANK1 (By similarity).				negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			ovary(1)	1	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGAGCTCTGAGAACACCTGTG	0.652													9	27					0	0	0	0	A	145154328	A	A	145154328	2	1	246	1	0	0	0	0	0	0	0	1	14332	933	33	2		2	SHARPIN	8	145154328	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1459222	145154328	1209694	111	45174											
KIFC2	90990	broad.mit.edu	37	chr8	145692461	145692461	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgtccagctgggggcggaaGagagctgcgggggcccggcg	5	3	21	12	5	0	1	0	0	0	1	1	3	1	2	3	6	3	2	3	6	1	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr8:145692461G>A	uc003zcz.2	+	3	363	c.298G>A	c.(298-300)GAG>AAG	p.E100K	CYHR1_uc003zcv.2_5'Flank|CYHR1_uc003zcw.2_5'Flank|CYHR1_uc003zcx.2_5'Flank|CYHR1_uc003zcy.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	100					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GGGGGCGGAAGAGAGCTGCGG	0.746											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	7					0	0	0	0	A	145692461	A	A	145692461	3	1	246	1	0	0	0	0	1	0	0	0	8352	943	33	2	308	2	KIFC2	8	145692461	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	538133	145692461	671561	112	45175											
CCIN	881	broad.mit.edu	37	chr9	36169709	36169709	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accgctgatgagcttttcatCaccattgacaccagttacct	10	12	6	13	1	2	3	2	3	0	0	2	3	2	3	4	0	2	3	4	0	1	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr9:36169709C>T	uc003zzb.3	+	1	321	c.210C>T	c.(208-210)ATC>ATT	p.I70I		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	70	BTB.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			AGCTTTTCATCACCATTGACA	0.532													8	25					0	0	0	0	T	36169709	T	T	36169709	2	4	246	1	0	0	0	0	0	0	0	1	2891	816	29	2		2	CCIN	9	36169709	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08		36169709	105043722	113	45176											
VPS13A	23230	broad.mit.edu	37	chr9	79936594	79936594	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttaagtatggattatatccGaaccaaggacaatgatcatt	15	13	7	6	1	1	1	1	1	0	0	2	4	2	3	2	2	1	1	2	2	7	6	rs145524733		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr9:79936594G>A	uc004akr.2	+	44	6022	c.5762G>A	c.(5761-5763)CGA>CAA	p.R1921Q	VPS13A_uc004akp.3_Missense_Mutation_p.R1921Q|VPS13A_uc004akq.3_Missense_Mutation_p.R1921Q|VPS13A_uc004aks.2_Missense_Mutation_p.R1882Q|VPS13A_uc004akt.2_Missense_Mutation_p.R261Q	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1921					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						GATTATATCCGAACCAAGGAC	0.353													13	39					0	0	0	0	A	79936594	A	A	79936594	3	1	246	1	0	0	0	0	1	0	0	0	17257	1058	37	1	5936	1	VPS13A	9	79936594	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	43766885	79936594	61276837	114	45177											
SLC28A3	64078	broad.mit.edu	37	chr9	86912933	86912933	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataagacaggtctccagtaaAcctatacagaaagatcaagt	18	8	7	8	0	2	3	1	0	1	3	3	3	2	3	2	1	2	1	2	1	7	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr9:86912933A>C	uc010mpz.2	-	7	796	c.671T>G	c.(670-672)GTT>GGT	p.V224G	SLC28A3_uc011lsy.1_Missense_Mutation_p.V155G|SLC28A3_uc004anu.1_Missense_Mutation_p.V224G|SLC28A3_uc010mqb.2_Missense_Mutation_p.V155G	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	224	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TCTCCAGTAAACCTATACAGA	0.418													8	64					0	0	0	0	C	86912933	C	C	86912933	3	2	246	1	0	0	0	0	1	0	0	0	14597	57	2	5	1452	5	SLC28A3	9	86912933	Missense_Mutation	SNP	A	TCGA-CV-7406-01A-11D-2078-08	6976339	86912933	54300498	115	45178											
LCN2	3934	broad.mit.edu	37	chr9	130914289	130914289	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaaaacagggagtacttcAagatcaccctctacggtggg	12	8	10	11	1	4	1	3	0	1	1	4	2	4	2	1	3	3	1	1	3	5	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr9:130914289A>C	uc004bto.1	+	4	533	c.460A>C	c.(460-462)AAG>CAG	p.K154Q	LCN2_uc011map.1_Missense_Mutation_p.K154Q	NM_005564	NP_005555	P80188	NGAL_HUMAN	lipocalin 2 precursor	154		Catecholate-type ferric siderophore.			apoptosis|innate immune response|regulation of apoptosis|siderophore transport		iron ion binding|transporter activity				0						GGAGTACTTCAAGATCACCCT	0.547													24	79					0	0	0	0	C	130914289	C	C	130914289	3	2	246	1	0	0	0	0	1	0	0	0	8724	131	5	5	474	5	LCN2	9	130914289	Missense_Mutation	SNP	A	TCGA-CV-7406-01A-11D-2078-08	44001356	130914289	10299142	116	45179											
KLF6	1316	broad.mit.edu	37	chr10	3822362	3822362	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcggaagtgcctggttaactCatcacttcttgcaaaacgcc	10	11	8	12	2	3	0	2	0	1	0	4	1	3	1	2	2	4	2	2	2	4	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:3822362C>G	uc001iha.2	-	3	1003	c.736G>C	c.(736-738)GAG>CAG	p.E246Q	KLF6_uc010qaj.1_Intron|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Missense_Mutation_p.E204Q	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	246	C2H2-type 2.				B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		CTGGTTAACTCATCACTTCTT	0.542													24	80					0	0	0	0	G	3822362	G	G	3822362	3	3	246	1	0	0	0	0	1	0	0	0	8389	835	29	2	123	2	KLF6	10	3822362	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08		3822362	131712385	117	45180											
SVIL	6840	broad.mit.edu	37	chr10	29821993	29821993	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttctttttcttctccttCtccttccccttcttcttctt	0	25	0	16	0	8	0	0	0	8	0	11	0	9	0	4	0	0	0	4	0	0	11			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:29821993C>T	uc001iut.1	-	8	2056	c.1303G>A	c.(1303-1305)GAA>AAA	p.E435K	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_Missense_Mutation_p.E435K	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	435					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				tcttctccttctccttcccct	0.408													23	22					0	0	0	0	T	29821993	T	T	29821993	3	4	246	1	0	0	0	0	1	0	0	0	15487	922	32	2	5465	2	SVIL	10	29821993	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	25999631	29821993	105712754	118	45181											
FZD8	8325	broad.mit.edu	37	chr10	35929479	35929479	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggaaggtggagacggtggcGaaggtggacacgaagcagag	13	3	20	5	3	0	2	0	0	0	2	0	7	0	4	0	7	1	1	0	7	3	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:35929479G>A	uc001iyz.1	-	1	884	c.879C>T	c.(877-879)TTC>TTT	p.F293F		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	293	Helical; Name=1; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						AGACGGTGGCGAAGGTGGACA	0.622													19	26					0	0	0	0	A	35929479	A	A	35929479	2	1	246	1	0	0	0	0	0	0	0	1	6170	1049	37	1		1	FZD8	10	35929479	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	6107486	35929479	99605268	119	45182											
ANKRD30A	91074	broad.mit.edu	37	chr10	37482137	37482137	+	Frame_Shift_Del	DEL	T	-	-																															ccctgcagaatgaaagtttcTattccaactaaagccttaga																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:37482137delT	uc001iza.1	+	27	2496	c.2397delT	c.(2395-2397)TCTfs	p.S799fs		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	855						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TGAAAGTTTCTATTCCAACTA	0.264													---	---	---								-	37482137	-	-	37482137	7	5	246	1	0	1	0	1	0	0	0	0	658	1509	53	0	2503	0	ANKRD30A	10	37482137	Frame_Shift_Del	DEL	T	TCGA-CV-7406-01A-11D-2078-08	1552658	37482137	98052610	120	45183											
PAX2	5076	broad.mit.edu	37	chr10	102510539	102510539	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtggtggacaagattgctGaatacaaacgacagaacccg	16	6	11	8	2	0	3	0	1	0	2	0	5	0	4	1	2	4	1	1	2	6	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:102510539G>T	uc001krk.3	+	3	851	c.301G>T	c.(301-303)GAA>TAA	p.E101*	PAX2_uc001krl.3_Nonsense_Mutation_p.E101*|PAX2_uc001krm.3_Nonsense_Mutation_p.E101*|PAX2_uc001kro.3_Nonsense_Mutation_p.E101*|PAX2_uc001krn.3_Nonsense_Mutation_p.E101*|PAX2_uc010qps.1_Nonsense_Mutation_p.E100*|PAX2_uc001krp.1_Nonsense_Mutation_p.E105*	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	101	Paired.				anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		CAAGATTGCTGAATACAAACG	0.587													32	35					1.56442e-22	1.70422e-22	1	0	T	102510539	T	T	102510539	4	4	246	1	0	0	0	0	0	1	0	0	11533	1291	45	2	311	2	PAX2	10	102510539	Nonsense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	65028402	102510539	33024208	121	45184											
SFXN4	119559	broad.mit.edu	37	chr10	120917539	120917539	+	Missense_Mutation	SNP	C	A	A																															acctgaggtaaaatcacggaCttgatccctttcagtggcgt																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:120917539C>A	uc001leb.2	-	7	441	c.396G>T	c.(394-396)AAG>AAT	p.K132N	SFXN4_uc001ldy.2_Missense_Mutation_p.K16N|SFXN4_uc001ldz.2_Missense_Mutation_p.K16N|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	132					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		AAATCACGGACTTGATCCCTT	0.428													8	52					5.4927e-09	5.71598e-09	1	0	A	120917539	A	A	120917539	3	1	246	1	0	0	0	0	1	0	0	0	14262	564	20	4	649	4	SFXN4	10	120917539	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	18407000	120917539	14617208	122	45185	97	2									
SFXN4	119559	broad.mit.edu	37	chr10	120917544	120917544	+	Missense_Mutation	SNP	T	A	A																															aggtaaaatcacggacttgaTccctttcagtggcgtcattg																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr10:120917544T>A	uc001leb.2	-	7	436	c.391A>T	c.(391-393)ATC>TTC	p.I131F	SFXN4_uc001ldy.2_Missense_Mutation_p.I15F|SFXN4_uc001ldz.2_Missense_Mutation_p.I15F|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	131	Helical; (Potential).				iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		ACGGACTTGATCCCTTTCAGT	0.418													8	48					0	0	0	0	A	120917544	A	A	120917544	3	1	246	1	0	0	0	0	1	0	0	0	14262	1435	50	5	654	5	SFXN4	10	120917544	Missense_Mutation	SNP	T	TCGA-CV-7406-01A-11D-2078-08	5	120917544	14617203	123	45186	97	2									
OR52A4	390053	broad.mit.edu	37	chr11	5142643	5142643	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggttcatggaggcttggctCagatttgatgatgatcaaaa	11	12	13	5	0	3	4	3	3	0	1	3	5	3	5	0	4	0	3	0	4	2	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:5142643C>T	uc001lzz.1	-	1	166	c.166G>A	c.(166-168)GAG>AAG	p.E56K	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AGGCTTGGCTCAGATTTGATG	0.428													20	48					0	0	0	0	T	5142643	T	T	5142643	3	4	246	1	0	0	0	0	1	0	0	0	11163	835	29	2	752	2	OR52A4	11	5142643	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08		5142643	129863873	124	45187											
HBE1	3046	broad.mit.edu	37	chr11	5290881	5290881	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagctgtcaaaaaatctctGggtccaggggtaaacaacga	16	7	10	8	1	2	0	1	0	1	0	4	1	3	0	1	3	3	2	1	3	7	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:5290881G>T	uc001mal.1	-	2	371	c.118C>A	c.(118-120)CAG>AAG	p.Q40K	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Missense_Mutation_p.Q40K	NM_005330	NP_005321	P02100	HBE_HUMAN	epsilon globin	40					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAAATCTCTGGGTCCAGGGG	0.463													17	41					4.7546e-09	4.96808e-09	1	0	T	5290881	T	T	5290881	3	4	246	1	0	0	0	0	1	0	0	0	7019	1357	47	4	333	4	HBE1	11	5290881	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	148238	5290881	129715635	125	45188											
CYB5R2	51700	broad.mit.edu	37	chr11	7689018	7689018	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggggtccttggtgatgtggcGaatgagctgcaacatgggtg	7	10	18	6	1	0	2	0	2	0	0	1	3	1	2	1	5	3	2	1	5	2	1	rs149733078		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:7689018G>A	uc001mfm.2	-	7	737	c.499C>T	c.(499-501)CGC>TGC	p.R167C	CYB5R2_uc001mfn.2_RNA|CYB5R2_uc009yfk.2_Missense_Mutation_p.R167C	NM_016229	NP_057313	Q6BCY4	NB5R2_HUMAN	cytochrome b5 reductase b5R.2	167	FAD (By similarity).				sterol biosynthetic process	membrane|soluble fraction	cytochrome-b5 reductase activity				0				Epithelial(150;5.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTGATGTGGCGAATGAGCTGC	0.552													19	68					0	0	0	0	A	7689018	A	A	7689018	3	1	246	1	0	0	0	0	1	0	0	0	4144	1058	37	1	343	1	CYB5R2	11	7689018	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	2398137	7689018	127317498	126	45189											
CD44	960	broad.mit.edu	37	chr11	35223298	35223298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctcattcaccatgagcatCatgaggaagaagagacccca	14	6	8	13	0	3	4	3	2	0	2	3	6	3	5	4	1	1	1	4	1	2	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:35223298C>T	uc001mvu.2	+	9	1551	c.1117C>T	c.(1117-1119)CAT>TAT	p.H373Y	CD44_uc001mvv.2_Missense_Mutation_p.H330Y|CD44_uc001mvw.2_Intron|CD44_uc001mvx.2_Intron|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Intron|CD44_uc010rer.1_Intron|CD44_uc009ykh.2_Intron|CD44_uc010res.1_Intron|CD44_uc010ret.1_Intron|CD44_uc010reu.1_Intron	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	373	Extracellular (Potential).|Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	CCATGAGCATCATGAGGAAGA	0.463													4	31					0	0	0	0	T	35223298	T	T	35223298	3	4	246	1	0	0	0	0	1	0	0	0	3032	826	29	2	1151	2	CD44	11	35223298	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	27534280	35223298	99783218	127	45190											
OR5D16	390144	broad.mit.edu	37	chr11	55606668	55606668	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaactctgtgccatgctggtGgttgtattgtatgcatgggg	7	14	14	6	0	1	0	0	0	1	0	1	0	1	0	1	4	4	5	1	4	3	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:55606668G>A	uc010rio.1	+	1	441	c.441G>A	c.(439-441)GTG>GTA	p.V147V		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				CCATGCTGGTGGTTGTATTGT	0.448													20	54					0	0	0	0	A	55606668	A	A	55606668	2	1	246	1	0	0	0	0	0	0	0	1	11210	1335	47	4		4	OR5D16	11	55606668	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	20383370	55606668	79399848	128	45191											
ENDOD1	23052	broad.mit.edu	37	chr11	94861543	94861543	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgttttcttcttgcagatCgatgaccccaacagcaacct	9	13	6	13	1	2	2	0	1	2	1	3	3	2	2	3	0	4	3	3	0	2	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:94861543C>T	uc001pfh.2	+	2	378	c.303C>T	c.(301-303)ATC>ATT	p.I101I		NM_015036	NP_055851	O94919	ENDD1_HUMAN	endonuclease domain containing 1 precursor	101						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding				0		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				TCTTGCAGATCGATGACCCCA	0.517													5	20					0	0	0	0	T	94861543	T	T	94861543	2	4	246	1	0	0	0	0	0	0	0	1	5138	874	31	1		1	ENDOD1	11	94861543	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	39254875	94861543	40144973	129	45192											
MMP8	4317	broad.mit.edu	37	chr11	102593222	102593222	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttaacataaaaccaccactGtcaggcactccacagcgagg	14	6	8	13	1	1	0	1	0	0	0	2	1	2	0	3	2	3	2	3	2	3	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr11:102593222G>A	uc001phe.2	-	2	384	c.285C>T	c.(283-285)GAC>GAT	p.D95D	MMP8_uc010rut.1_Silent_p.D30D|MMP8_uc010ruu.1_Silent_p.D72D	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	95	Cysteine switch (By similarity).				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		AACCACCACTGTCAGGCACTC	0.433													26	21					0	0	0	0	A	102593222	A	A	102593222	2	1	246	1	0	0	0	0	0	0	0	1	9721	1368	48	4		4	MMP8	11	102593222	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	7731679	102593222	32413294	130	45193											
C3AR1	719	broad.mit.edu	37	chr12	8212581	8212581	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaggcagcagaggaggtcCgccaaggtgaggtggaggaa	12	3	20	6	1	0	3	0	1	0	2	1	7	1	6	2	7	1	2	2	7	2	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:8212581C>T	uc001qtv.1	-	2	293	c.201G>A	c.(199-201)GCG>GCA	p.A67A		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	67	Helical; Name=2; (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		AGAGGAGGTCCGCCAAGGTGA	0.592													8	65					0	0	0	0	T	8212581	T	T	8212581	2	4	246	1	0	0	0	0	0	0	0	1	2215	639	23	1		1	C3AR1	12	8212581	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08		8212581	125639314	131	45194											
AICDA	57379	broad.mit.edu	37	chr12	8758041	8758041	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagggtctaggtcccagtccGagatgtagcggaggaagagc	10	6	16	9	2	1	2	0	0	1	2	3	5	3	4	2	4	2	1	2	4	3	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:8758041G>A	uc001qur.2	-	3	276	c.197C>T	c.(196-198)TCG>TTG	p.S66L	AICDA_uc001qup.1_Missense_Mutation_p.S61L|AICDA_uc001quq.1_Missense_Mutation_p.S61L|AICDA_uc009zgd.1_Intron	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	66					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					GTCCCAGTCCGAGATGTAGCG	0.587									Immune_Deficiency_with_Hyper-IgM				17	126					0	0	0	0	A	8758041	A	A	8758041	3	1	246	1	0	0	0	0	1	0	0	0	422	1059	37	1	411	1	AICDA	12	8758041	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	545460	8758041	125093854	132	45195											
PRB2	653247	broad.mit.edu	37	chr12	11546807	11546807	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaggaggtgggggaccttGaggctggttgcctccttgtg	4	11	19	7	0	0	1	0	1	0	0	1	4	1	4	3	7	1	2	3	7	0	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:11546807G>C	uc010shk.1	-	3	240	c.205C>G	c.(205-207)CAA>GAA	p.Q69E		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGGGGACCTTGAGGCTGGTTG	0.607													65	481					0	0	0	0	C	11546807	C	C	11546807	3	2	246	1	0	0	0	0	1	0	0	0	12505	1299	45	2	1049	2	PRB2	12	11546807	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	2788766	11546807	122305088	133	45196											
PTPRO	5800	broad.mit.edu	37	chr12	15742398	15742398	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcttttgcagtgctggcgtGggacggacaggaacattcat	8	12	13	8	2	2	0	1	0	1	0	2	3	2	3	0	4	3	2	0	4	1	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:15742398G>A	uc001rcv.1	+	25	3594	c.3420G>A	c.(3418-3420)GTG>GTA	p.V1140V	PTPRO_uc001rcw.1_Silent_p.V1112V|PTPRO_uc001rcx.1_Silent_p.V329V|PTPRO_uc001rcy.1_Silent_p.V329V|PTPRO_uc001rcz.1_Silent_p.V301V|PTPRO_uc001rda.1_Silent_p.V301V	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	1140	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.|Substrate binding (By similarity).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GTGCTGGCGTGGGACGGACAG	0.413													37	102					0	0	0	0	A	15742398	A	A	15742398	2	1	246	1	0	0	0	0	0	0	0	1	12874	1335	47	4		4	PTPRO	12	15742398	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	4195591	15742398	118109497	134	45197											
ADAMTS20	80070	broad.mit.edu	37	chr12	43847849	43847849	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtttacacatagcccatgacGgcaatgctataaaaataata	17	10	6	8	1	0	1	0	1	0	0	0	1	0	1	1	1	3	3	1	1	9	7			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:43847849G>T	uc010skx.1	-	12	1621	c.1621C>A	c.(1621-1623)CGT>AGT	p.R541S		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	541	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AGCCCATGACGGCAATGCTAT	0.368													8	27					0.00448238	0.00455353	1	0	T	43847849	T	T	43847849	3	4	246	1	0	0	0	0	1	0	0	0	266	1116	39	3	4222	3	ADAMTS20	12	43847849	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	28105451	43847849	90004046	135	45198											
SPRYD3	84926	broad.mit.edu	37	chr12	53470909	53470909	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaactcaccttaaagtatCtccatctacaaggatatgtt	13	13	5	10	0	3	1	1	1	2	0	4	2	3	2	2	1	2	2	2	1	7	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:53470909C>T	uc001sbt.1	-	2	181	c.160G>A	c.(160-162)GAT>AAT	p.D54N	SPRYD3_uc010snw.1_5'UTR	NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	54	B30.2/SPRY.									central_nervous_system(1)	1						CTTAAAGTATCTCCATCTACA	0.428													22	61					0	0	0	0	T	53470909	T	T	53470909	3	4	246	1	0	0	0	0	1	0	0	0	15175	913	32	2	1208	2	SPRYD3	12	53470909	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	9623060	53470909	80380986	136	45199											
STAT6	6778	broad.mit.edu	37	chr12	57492348	57492348	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggccttgatacggggggAtggagtgagagtgtggtggg	8	8	22	3	1	0	3	0	2	0	2	0	6	0	5	1	7	1	0	1	7	1	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:57492348A>G	uc009zpe.2	-	19	2350	c.2099T>C	c.(2098-2100)ATC>ACC	p.I700T	STAT6_uc009zpf.2_Missense_Mutation_p.I700T|STAT6_uc001sna.2_Missense_Mutation_p.I700T|STAT6_uc010srb.1_Missense_Mutation_p.I590T|STAT6_uc010src.1_Missense_Mutation_p.I590T|STAT6_uc010srd.1_Missense_Mutation_p.I590T|STAT6_uc009zpg.2_Missense_Mutation_p.I749T	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	700					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						ATACGGGGGGATGGAGTGAGA	0.547													4	72					0	0	0	0	G	57492348	G	G	57492348	3	3	246	1	0	0	0	0	1	0	0	0	15336	333	12	5	460	5	STAT6	12	57492348	Missense_Mutation	SNP	A	TCGA-CV-7406-01A-11D-2078-08	4021439	57492348	76359547	137	45200											
PIP4K2C	79837	broad.mit.edu	37	chr12	57994655	57994655	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggcatccacgacatcattcGgggctctgaaccagaggagg	11	6	13	11	2	2	2	1	1	1	1	4	4	3	3	2	5	1	2	2	5	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:57994655G>A	uc001sou.2	+	8	1006	c.875G>A	c.(874-876)CGG>CAG	p.R292Q	PIP4K2C_uc001sot.2_Missense_Mutation_p.R292Q|PIP4K2C_uc010srs.1_Missense_Mutation_p.R274Q|PIP4K2C_uc010srt.1_Missense_Mutation_p.R244Q	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	292	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					GACATCATTCGGGGCTCTGAA	0.562													71	151					0	0	0	0	A	57994655	A	A	57994655	3	1	246	1	0	0	0	0	1	0	0	0	11993	1116	39	1	905	1	PIP4K2C	12	57994655	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	502307	57994655	75857240	138	45201											
NEDD1	121441	broad.mit.edu	37	chr12	97345265	97345265	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagatgattaaacagtttCatatgcaactggtatgtatg	13	14	10	4	0	1	2	1	1	0	1	1	3	1	2	0	2	3	4	0	2	6	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:97345265C>T	uc001teu.3	+	15	2206	c.1867C>T	c.(1867-1869)CAT>TAT	p.H623Y	NEDD1_uc001tev.3_Missense_Mutation_p.H623Y|NEDD1_uc010svc.1_Missense_Mutation_p.H534Y|NEDD1_uc001tew.2_Missense_Mutation_p.H630Y|NEDD1_uc001tex.2_Missense_Mutation_p.H534Y	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	623					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						TAAACAGTTTCATATGCAACT	0.274													10	30					0	0	0	0	T	97345265	T	T	97345265	3	4	246	1	0	0	0	0	1	0	0	0	10363	826	29	2	1942	2	NEDD1	12	97345265	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	39350610	97345265	36506630	139	45202											
TCP11L2	255394	broad.mit.edu	37	chr12	106708240	106708240	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctgtaaatgagaactttCaattgaaacaagaggctctc	14	12	8	7	0	2	3	1	2	1	2	3	4	2	3	0	1	3	3	0	1	6	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:106708240C>T	uc001tln.2	+	3	436	c.262C>T	c.(262-264)CAA>TAA	p.Q88*	TCP11L2_uc001tll.2_Nonsense_Mutation_p.Q88*|TCP11L2_uc001tlm.2_Nonsense_Mutation_p.Q88*	NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	88										ovary(3)	3						TGAGAACTTTCAATTGAAACA	0.353													10	44					0	0	0	0	T	106708240	T	T	106708240	4	4	246	1	0	0	0	0	0	1	0	0	15781	827	29	2	268	2	TCP11L2	12	106708240	Nonsense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	9362975	106708240	27143655	140	45203											
MMP17	4326	broad.mit.edu	37	chr12	132325377	132325377	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acacccactttgacgatgacGaggcctggaccttccgctcc	8	8	9	16	3	0	2	0	2	0	0	2	5	2	3	5	2	0	1	5	2	0	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr12:132325377G>A	uc001ujc.1	+	4	781	c.682G>A	c.(682-684)GAG>AAG	p.E228K	MMP17_uc001ujd.1_Missense_Mutation_p.E144K	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	228					proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		TGACGATGACGAGGCCTGGAC	0.711													7	21					0	0	0	0	A	132325377	A	A	132325377	3	1	246	1	0	0	0	0	1	0	0	0	9709	1059	37	1	696	1	MMP17	12	132325377	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	25617137	132325377	1526518	141	45204											
STARD13	90627	broad.mit.edu	37	chr13	33684190	33684190	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggtgcttccacctccacaGaagccttccacagcttcagc	8	8	9	16	0	1	1	1	0	0	1	4	1	4	1	5	2	4	2	5	2	1	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr13:33684190G>A	uc001uuw.2	-	12	2993	c.2867C>T	c.(2866-2868)TCT>TTT	p.S956F	STARD13_uc001uuu.2_Missense_Mutation_p.S948F|STARD13_uc001uuv.2_Missense_Mutation_p.S838F|STARD13_uc001uux.2_Missense_Mutation_p.S921F|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	956	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		CACCTCCACAGAAGCCTTCCA	0.562											OREG0022359	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	21					0	0	0	0	A	33684190	A	A	33684190	3	1	246	1	0	0	0	0	1	0	0	0	15322	942	33	2	486	2	STARD13	13	33684190	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08		33684190	81485688	142	45205											
HTR2A	3356	broad.mit.edu	37	chr13	47469754	47469754	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctctagggacactgccatGatgacgagtatgtttccagc	9	12	10	10	1	1	2	0	2	1	0	3	4	2	3	2	1	2	2	2	1	2	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr13:47469754G>C	uc001vbq.2	-	1	422	c.288C>G	c.(286-288)ATC>ATG	p.I96M	HTR2A_uc001vbr.2_Intron|HTR2A_uc010acr.2_Missense_Mutation_p.I96M	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	96	Helical; Name=1; (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ACACTGCCATGATGACGAGTA	0.458													20	29					0	0	0	0	C	47469754	C	C	47469754	3	2	246	1	0	0	0	0	1	0	0	0	7480	1280	45	2	1139	2	HTR2A	13	47469754	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	13785564	47469754	67700124	143	45206											
PCDH9	5101	broad.mit.edu	37	chr13	67801807	67801807	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaatatgcacctccacttGaccctctttaaacactggcc	10	11	6	14	0	1	1	0	1	1	0	2	2	2	2	4	2	2	1	4	2	4	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr13:67801807G>A	uc001vik.2	-	2	1458	c.766C>T	c.(766-768)CAA>TAA	p.Q256*	PCDH9_uc001vil.2_Nonsense_Mutation_p.Q256*|PCDH9_uc010thl.1_Nonsense_Mutation_p.Q256*|PCDH9_uc001vin.3_Nonsense_Mutation_p.Q256*	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	256	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ACCTCCACTTGACCCTCTTTA	0.473													24	34					0	0	0	0	A	67801807	A	A	67801807	4	1	246	1	0	0	0	0	0	1	0	0	11572	1299	45	2	2963	2	PCDH9	13	67801807	Nonsense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	20332053	67801807	47368071	144	45207											
GNPNAT1	64841	broad.mit.edu	37	chr14	53251317	53251317	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agctgtattctgactccagtCcacttctttgagtagacttg	8	15	8	10	0	2	3	0	2	2	1	4	3	4	3	2	0	1	3	2	0	2	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr14:53251317C>T	uc001xab.2	-	2	307	c.52G>A	c.(52-54)GAC>AAC	p.D18N		NM_198066	NP_932332	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	18					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity				0	Breast(41;0.176)					TGACTCCAGTCCACTTCTTTG	0.373													139	15					0	0	0	0	T	53251317	T	T	53251317	3	4	246	1	0	0	0	0	1	0	0	0	6581	855	30	2	522	2	GNPNAT1	14	53251317	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08		53251317	54098223	145	45208											
DIO2	1734	broad.mit.edu	37	chr14	80669404	80669404	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaagtcagccactgaggaGaactcttccaccagtttgcg	11	8	11	11	1	2	2	1	1	1	1	3	4	3	3	3	2	3	1	3	2	2	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr14:80669404G>A	uc010tvq.1	-	4	852	c.450C>T	c.(448-450)TTC>TTT	p.F150F	DIO2_uc010tvp.1_Silent_p.F186F|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_3'UTR|DIO2_uc010tvr.1_Silent_p.F150F|DIO2_uc010asy.2_3'UTR	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	150					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		CCACTGAGGAGAACTCTTCCA	0.557											OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	15					0	0	0	0	A	80669404	A	A	80669404	2	1	246	1	0	0	0	0	0	0	0	1	4547	933	33	2		2	DIO2	14	80669404	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	27418087	80669404	26680136	146	45209											
GPR65	8477	broad.mit.edu	37	chr14	88477470	88477470	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaaagggagtgcttttctCatgtacatgaatttttacag	11	15	9	6	0	1	1	1	1	1	0	2	2	1	2	0	1	4	3	0	1	4	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr14:88477470C>T	uc001xvv.2	+	2	809	c.279C>T	c.(277-279)CTC>CTT	p.L93L		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	93	Helical; Name=3; (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						GTGCTTTTCTCATGTACATGA	0.403													52	97					0	0	0	0	T	88477470	T	T	88477470	2	4	246	1	0	0	0	0	0	0	0	1	6744	813	29	2		2	GPR65	14	88477470	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	7808066	88477470	18872070	147	45210											
BTBD7	55727	broad.mit.edu	37	chr14	93709138	93709138	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggaaggggtgcgtctgctGagagcaggagtagaaggtct	9	7	20	5	1	2	2	0	1	2	2	2	5	2	4	0	6	3	3	0	6	3	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr14:93709138G>A	uc001ybo.2	-	11	3206	c.2880C>T	c.(2878-2880)CTC>CTT	p.L960L	BTBD7_uc010aur.2_Silent_p.L485L|BTBD7_uc010two.1_Silent_p.L780L|BTBD7_uc001ybp.2_Silent_p.L609L	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	960										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		TGCGTCTGCTGAGAGCAGGAG	0.478													24	34					0	0	0	0	A	93709138	A	A	93709138	2	1	246	1	0	0	0	0	0	0	0	1	1551	1277	45	2		2	BTBD7	14	93709138	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	5231668	93709138	13640402	148	45211											
MGA	23269	broad.mit.edu	37	chr15	42019556	42019556	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgtgaagggcaaactgctCactggaattaaatctccacg	13	9	9	10	1	2	1	1	1	1	0	3	2	2	2	1	2	2	2	1	2	5	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr15:42019556C>T	uc010ucy.1	+	10	3790	c.3609C>T	c.(3607-3609)CTC>CTT	p.L1203L	MGA_uc010ucz.1_Silent_p.L1203L	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1203						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GCAAACTGCTCACTGGAATTA	0.403													43	118					0	0	0	0	T	42019556	T	T	42019556	2	4	246	1	0	0	0	0	0	0	0	1	9593	813	29	2		2	MGA	15	42019556	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08		42019556	60511836	149	45212											
PKM2	5315	broad.mit.edu	37	chr15	72502754	72502754	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccacagcaacgggccggtaGaggatggggtcagaagcaaa	13	3	16	9	2	1	2	1	0	0	2	1	3	1	3	2	5	3	3	2	5	4	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr15:72502754G>A	uc002atx.1	-	4	553	c.312C>T	c.(310-312)CTC>CTT	p.L104L	PKM2_uc002att.1_5'Flank|PKM2_uc002atu.1_5'Flank|PKM2_uc010bit.1_Silent_p.L109L|PKM2_uc010uki.1_Silent_p.L178L|PKM2_uc002atv.1_Silent_p.L139L|PKM2_uc002atw.1_Silent_p.L104L|PKM2_uc002aty.1_Silent_p.L104L|PKM2_uc010ukj.1_Silent_p.L89L|PKM2_uc010ukk.1_Intron|PKM2_uc010biu.1_Silent_p.L125L|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	104					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	CGGGCCGGTAGAGGATGGGGT	0.562													59	44					0	0	0	0	A	72502754	A	A	72502754	2	1	246	1	0	0	0	0	0	0	0	1	12032	929	33	2		2	PKM2	15	72502754	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	30483198	72502754	30028638	150	45213											
NEIL1	79661	broad.mit.edu	37	chr15	75641389	75641389	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcagtgcctaccgcatctCagcttcagcccgcggcaagg	8	6	12	15	3	2	0	2	0	1	0	3	1	2	0	3	2	5	4	3	2	2	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr15:75641389C>T	uc002bad.2	+	2	649	c.143C>T	c.(142-144)TCA>TTA	p.S48L	NEIL1_uc002bae.2_Missense_Mutation_p.S134L	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1	48					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			ovary(1)	1						TACCGCATCTCAGCTTCAGCC	0.657								BER_DNA_glycosylases					40	18					0	0	0	0	T	75641389	T	T	75641389	3	4	246	1	0	0	0	0	1	0	0	0	10372	838	29	2	145	2	NEIL1	15	75641389	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	3138635	75641389	26890003	151	45214											
TTC23	64927	broad.mit.edu	37	chr15	99758831	99758831	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atccgtgcttcaatttctatCcattcttcctttataattct	8	20	2	11	1	4	0	1	0	3	0	7	0	7	0	3	0	1	1	3	0	4	9			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr15:99758831C>T	uc002bur.2	-	7	1074	c.543G>A	c.(541-543)TGG>TGA	p.W181*	TTC23_uc002bus.2_Nonsense_Mutation_p.W181*|TTC23_uc002but.2_Nonsense_Mutation_p.W181*|TTC23_uc002buu.2_Nonsense_Mutation_p.W181*|TTC23_uc002buv.2_Nonsense_Mutation_p.W181*|TTC23_uc002bux.2_Nonsense_Mutation_p.W181*|TTC23_uc002buw.2_Nonsense_Mutation_p.W181*|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Nonsense_Mutation_p.W181*|TTC23_uc010bor.2_Nonsense_Mutation_p.W181*|TTC23_uc002buz.2_Nonsense_Mutation_p.W181*	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	181							binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			CAATTTCTATCCATTCTTCCT	0.383													90	62					0	0	0	0	T	99758831	T	T	99758831	4	4	246	1	0	0	0	0	0	1	0	0	16758	856	30	2	828	2	TTC23	15	99758831	Nonsense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	24117442	99758831	2772561	152	45215											
ABCA3	21	broad.mit.edu	37	chr16	2376270	2376270	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggaccgtcaccaggaccttCcgcttctggaagagatacaa	12	7	10	12	2	2	1	1	0	1	1	3	5	3	4	4	3	1	1	4	3	3	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr16:2376270C>T	uc002cpy.1	-	5	772	c.60G>A	c.(58-60)CGG>CGA	p.R20R	ABCA3_uc010bsk.1_Silent_p.R20R|ABCA3_uc010bsl.1_Silent_p.R20R|ABCA3_uc002cpz.1_Silent_p.R20R	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	20					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CCAGGACCTTCCGCTTCTGGA	0.567													44	25					0	0	0	0	T	2376270	T	T	2376270	2	4	246	1	0	0	0	0	0	0	0	1	33	842	30	2		2	ABCA3	16	2376270	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08		2376270	87978483	153	45216											
NLRC3	197358	broad.mit.edu	37	chr16	3614473	3614473	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaggcggacgaagtgcctCaccagggtggtcttgcccat	8	7	14	12	2	2	1	1	0	1	1	2	3	2	2	3	4	2	0	3	4	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr16:3614473C>T	uc010btn.2	-	5	876	c.465G>A	c.(463-465)GTG>GTA	p.V155V		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	155	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CGAAGTGCCTCACCAGGGTGG	0.657													32	13					0	0	0	0	T	3614473	T	T	3614473	2	4	246	1	0	0	0	0	0	0	0	1	10522	813	29	2		2	NLRC3	16	3614473	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	1238203	3614473	86740280	154	45217											
PRR14	78994	broad.mit.edu	37	chr16	30665567	30665567	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagagctgagcccatgaggAtagttcgccagccaacgcct	10	6	11	14	2	0	3	0	2	0	1	1	4	0	4	5	1	4	2	5	1	2	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr16:30665567A>G	uc002dyy.2	+	7	823	c.565A>G	c.(565-567)ATA>GTA	p.I189V	PRR14_uc002dyz.2_Missense_Mutation_p.I34V|PRR14_uc002dza.2_Missense_Mutation_p.I189V|PRR14_uc002dzb.1_Missense_Mutation_p.I3V	NM_024031	NP_076936	Q9BWN1	PRR14_HUMAN	proline rich 14	189	Pro-rich.										0			Colorectal(24;0.103)			GCCCATGAGGATAGTTCGCCA	0.582													15	239					0	0	0	0	G	30665567	G	G	30665567	3	3	246	1	0	0	0	0	1	0	0	0	12648	333	12	5	587	5	PRR14	16	30665567	Missense_Mutation	SNP	A	TCGA-CV-7406-01A-11D-2078-08	27051094	30665567	59689186	155	45218											
CDH16	1014	broad.mit.edu	37	chr16	66945110	66945110	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgggcctccacaagcacCgtgtaggtgtccccaggctg	6	8	12	15	1	0	0	0	0	0	0	3	0	3	0	6	3	1	3	6	3	2	1	rs148829305		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr16:66945110C>G	uc002eql.2	-	14	1972	c.1899G>C	c.(1897-1899)ACG>ACC	p.T633T	CDH16_uc010cdy.2_Silent_p.T633T|CDH16_uc002eqm.2_Silent_p.T536T	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	633	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CCACAAGCACCGTGTAGGTGT	0.612													9	18					0	0	0	0	G	66945110	G	G	66945110	2	3	246	1	0	0	0	0	0	0	0	1	3116	639	23	3		3	CDH16	16	66945110	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	36279543	66945110	23409643	156	45219											
KIAA0513	9764	broad.mit.edu	37	chr16	85106591	85106591	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctggtgcagtcttttgcaGtggtgctgttcgagtaagta	6	14	14	7	1	1	0	0	0	1	0	2	1	1	0	1	2	3	6	1	2	2	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr16:85106591G>T	uc002fiu.2	+	4	710	c.490G>T	c.(490-492)GTG>TTG	p.V164L	KIAA0513_uc002fis.3_Missense_Mutation_p.V164L|KIAA0513_uc010voj.1_Missense_Mutation_p.V164L|KIAA0513_uc002fit.2_Missense_Mutation_p.V164L	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	164						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		GTCTTTTGCAGTGGTGCTGTT	0.567													20	65					8.04996e-18	8.62255e-18	1	0	T	85106591	T	T	85106591	3	4	246	1	0	0	0	0	1	0	0	0	8220	1029	36	4	500	4	KIAA0513	16	85106591	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	18161481	85106591	5248162	157	45220											
MED11	400569	broad.mit.edu	37	chr17	4635163	4635163	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgcttcagtgcaacacgtgGaggcggagctgtcagctcag	8	7	14	12	3	3	0	3	0	0	0	3	2	3	2	1	3	4	4	1	3	1	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:4635163G>A	uc002fyp.2	+	2	240	c.178G>A	c.(178-180)GAG>AAG	p.E60K		NM_001001683	NP_001001683	Q9P086	MED11_HUMAN	mediator complex subunit 11	60					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	protein binding				0						GCAACACGTGGAGGCGGAGCT	0.607											OREG0024104	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	20					0	0	0	0	A	4635163	A	A	4635163	3	1	246	1	0	0	0	0	1	0	0	0	9480	1175	41	2	184	2	MED11	17	4635163	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08		4635163	76560047	158	45221											
CAMTA2	23125	broad.mit.edu	37	chr17	4889259	4889259	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttcttggggagaaagatCttcaggtggtggctgttttc	7	14	14	6	0	3	2	1	0	2	2	4	3	3	2	0	5	1	3	0	5	1	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:4889259C>A	uc002gah.1	-	3	159	c.51G>T	c.(49-51)AAG>AAT	p.K17N	CAMTA2_uc010cku.1_Missense_Mutation_p.K40N|CAMTA2_uc002gag.1_Missense_Mutation_p.K40N|CAMTA2_uc002gai.1_Missense_Mutation_p.K19N|CAMTA2_uc010vsu.1_5'UTR	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	17					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GGAGAAAGATCTTCAGGTGGT	0.537													26	41					4.59853e-10	4.84454e-10	1	0	A	4889259	A	A	4889259	3	1	246	1	0	0	0	0	1	0	0	0	2626	912	32	2	3691	2	CAMTA2	17	4889259	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	254096	4889259	76305951	159	45222											
NLRP1	22861	broad.mit.edu	37	chr17	5440230	5440230	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggccctcagttcctgcctCatctcatcactcagagttgt	7	12	8	14	0	5	1	5	0	1	1	7	1	6	1	3	1	1	2	3	1	0	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:5440230C>T	uc002gci.2	-	8	3456	c.2901G>A	c.(2899-2901)ATG>ATA	p.M967I	NLRP1_uc002gcg.1_Missense_Mutation_p.M967I|NLRP1_uc002gck.2_Missense_Mutation_p.M967I|NLRP1_uc002gcj.2_Intron|NLRP1_uc002gcl.2_Intron|NLRP1_uc002gch.3_Missense_Mutation_p.M967I|NLRP1_uc010clh.2_Missense_Mutation_p.M967I	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	967	LRR 6.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GTTCCTGCCTCATCTCATCAC	0.622													14	26					0	0	0	0	T	5440230	T	T	5440230	3	4	246	1	0	0	0	0	1	0	0	0	10525	826	29	2	1635	2	NLRP1	17	5440230	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	550971	5440230	75754980	160	45223											
SLC13A5	284111	broad.mit.edu	37	chr17	6599185	6599185	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagggccccagcttccggtaCtcctcctgcagcaccttgag	7	8	10	16	1	0	1	0	1	0	0	3	1	3	1	6	2	4	4	6	2	2	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:6599185C>A	uc002gdj.2	-	7	1003	c.915G>T	c.(913-915)GAG>GAT	p.E305D	SLC13A5_uc010vtf.1_Missense_Mutation_p.E305D|SLC13A5_uc010clq.2_Missense_Mutation_p.E262D|SLC13A5_uc002gdk.2_Missense_Mutation_p.E288D|SLC13A5_uc002gdl.1_Missense_Mutation_p.E287D	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	305						integral to membrane	citrate transmembrane transporter activity				0						GCTTCCGGTACTCCTCCTGCA	0.557													33	84					3.21399e-22	3.48637e-22	1	0	A	6599185	A	A	6599185	3	1	246	1	0	0	0	0	1	0	0	0	14460	564	20	4	815	4	SLC13A5	17	6599185	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	1158955	6599185	74596025	161	45224											
C17orf81	23587	broad.mit.edu	37	chr17	7156110	7156110	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccgtggagtgggaggggcGcagtctcttgaaggcgcttg	5	10	18	8	3	1	1	0	1	1	0	3	3	2	3	1	5	0	2	1	5	1	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:7156110G>A	uc002gfg.1	+	3	223	c.116G>A	c.(115-117)CGC>CAC	p.R39H	DULLARD_uc002gfd.2_5'Flank|DULLARD_uc002gfe.2_5'Flank|DULLARD_uc002gff.2_5'Flank|DULLARD_uc002gfc.2_5'Flank|C17orf81_uc002gfj.2_Missense_Mutation_p.R39H|C17orf81_uc010cmb.2_Missense_Mutation_p.R39H|C17orf81_uc002gfh.1_Missense_Mutation_p.R39H|C17orf81_uc002gfi.1_Missense_Mutation_p.R39H|C17orf81_uc002gfk.1_Missense_Mutation_p.R39H|C17orf81_uc002gfl.1_Missense_Mutation_p.R39H	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	39					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						TGGGAGGGGCGCAGTCTCTTG	0.587													3	29					0	0	0	0	A	7156110	A	A	7156110	3	1	246	1	0	0	0	0	1	0	0	0	1894	1087	38	1	122	1	C17orf81	17	7156110	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	556925	7156110	74039100	162	45225											
DNAH2	146754	broad.mit.edu	37	chr17	7734149	7734149	+	Frame_Shift_Del	DEL	T	-	-																															tgtgaccagtctctatcaacTcccttccaccggtgaggggg																										TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:7734149delT	uc002giu.1	+	78	12233	c.12219delT	c.(12217-12219)ACTfs	p.T4073fs	DNAH2_uc010cnm.1_Frame_Shift_Del_p.T1011fs	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4073	TPR 4.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTCTATCAACTCCCTTCCACC	0.567													---	---	---								-	7734149	-	-	7734149	7	5	246	1	0	1	0	1	0	0	0	0	4624	1538	54	0	12529	0	DNAH2	17	7734149	Frame_Shift_Del	DEL	T	TCGA-CV-7406-01A-11D-2078-08	578039	7734149	73461061	163	45226											
ALOXE3	59344	broad.mit.edu	37	chr17	8006700	8006700	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggttgttacagctgatgtTcacttcagggagggtgtcta	8	13	14	6	0	3	1	2	1	1	0	3	3	3	2	0	3	2	4	0	3	2	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:8006700T>C	uc010cnr.2	-	15	2267	c.1897A>G	c.(1897-1899)AAC>GAC	p.N633D	ALOXE3_uc002gka.2_Missense_Mutation_p.N789D|ALOXE3_uc010vuo.1_Missense_Mutation_p.N765D	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	633	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						CAGCTGATGTTCACTTCAGGG	0.557													26	44					0	0	0	0	C	8006700	C	C	8006700	3	2	246	1	0	0	0	0	1	0	0	0	542	1783	62	5	246	5	ALOXE3	17	8006700	Missense_Mutation	SNP	T	TCGA-CV-7406-01A-11D-2078-08	272551	8006700	73188510	164	45227											
MYH8	4626	broad.mit.edu	37	chr17	10301955	10301955	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgtgtgccagggcgttcttGgcctgcagaagtagcagttc	6	10	15	10	2	1	1	0	0	1	1	2	1	1	1	2	2	3	5	2	2	2	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:10301955G>A	uc002gmm.2	-	30	4079	c.3984C>T	c.(3982-3984)GCC>GCT	p.A1328A	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1328	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GGGCGTTCTTGGCCTGCAGAA	0.507									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				30	45					0	0	0	0	A	10301955	A	A	10301955	2	1	246	1	0	0	0	0	0	0	0	1	10094	1335	47	4		4	MYH8	17	10301955	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	2295255	10301955	70893255	165	45228											
DNAH9	1770	broad.mit.edu	37	chr17	11696943	11696943	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaggactttgatctttttGataaaatccagacagaagtg	16	12	8	5	0	1	4	0	2	1	2	2	5	2	5	1	1	0	0	1	1	5	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:11696943G>C	uc002gne.2	+	42	8253	c.8185G>C	c.(8185-8187)GAT>CAT	p.D2729H	DNAH9_uc010coo.2_Missense_Mutation_p.D2023H	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2729					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGATCTTTTTGATAAAATCCA	0.323													13	36					0	0	0	0	C	11696943	C	C	11696943	3	2	246	1	0	0	0	0	1	0	0	0	4630	1290	45	2	8351	2	DNAH9	17	11696943	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1394988	11696943	69498267	166	45229											
LRRC48	83450	broad.mit.edu	37	chr17	17891328	17891328	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgagcttgttcaacaaccgGatctccaagatcgactccct	10	10	7	14	2	2	2	1	1	1	1	5	4	3	3	3	1	3	2	3	1	3	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:17891328G>A	uc010vxd.1	+	6	739	c.360G>A	c.(358-360)CGG>CGA	p.R120R	LRRC48_uc002gsa.2_Silent_p.R120R|LRRC48_uc010vxc.1_Silent_p.R120R|LRRC48_uc002gsb.2_Silent_p.R120R	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	120	LRR 4.					cytoplasm				pancreas(1)	1	all_neural(463;0.228)					TCAACAACCGGATCTCCAAGA	0.557													4	45					0	0	0	0	A	17891328	A	A	17891328	2	1	246	1	0	0	0	0	0	0	0	1	9055	1161	41	2		2	LRRC48	17	17891328	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	6194385	17891328	63303882	167	45230											
PTRF	284119	broad.mit.edu	37	chr17	40574759	40574759	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgcgcacggtcttcacgttGacgctgaccttgcgcacctt	5	10	10	16	6	2	2	1	2	1	0	2	2	2	2	3	1	1	4	3	1	0	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:40574759G>A	uc002hzo.2	-	1	516	c.357C>T	c.(355-357)GTC>GTT	p.V119V	PTRF_uc010wgi.1_Silent_p.V101V	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	119					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		TCTTCACGTTGACGCTGACCT	0.642													3	12					0	0	0	0	A	40574759	A	A	40574759	2	1	246	1	0	0	0	0	0	0	0	1	12880	1277	45	2		2	PTRF	17	40574759	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	22683431	40574759	40620451	168	45231											
TUBG2	27175	broad.mit.edu	37	chr17	40812702	40812702	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgacatcatagaccgagaaGcagatggaagtgacagtttg	14	9	12	6	1	1	5	1	2	0	3	1	7	1	6	1	1	1	2	1	1	3	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:40812702G>A	uc010wgr.1	+	4	632	c.376G>A	c.(376-378)GCA>ACA	p.A126T	TUBG2_uc002iaq.2_5'UTR|TUBG2_uc002iar.2_5'UTR|TUBG2_uc002ias.2_5'UTR|TUBG2_uc002iap.2_5'UTR	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	126					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		AGACCGAGAAGCAGATGGAAG	0.507													10	11					0	0	0	0	A	40812702	A	A	40812702	3	1	246	1	0	0	0	0	1	0	0	0	16833	971	34	4	390	4	TUBG2	17	40812702	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	237943	40812702	40382508	169	45232											
DBF4B	80174	broad.mit.edu	37	chr17	42786685	42786685	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctcaggagacgattgcctCgagctggagagttccatggc	8	10	13	10	2	1	2	1	0	1	2	4	6	2	2	2	3	2	2	2	3	0	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:42786685C>T	uc002ihf.2	+	2	246	c.33C>T	c.(31-33)CTC>CTT	p.L11L	DBF4B_uc002ihd.1_Silent_p.L11L|DBF4B_uc010wjb.1_RNA|DBF4B_uc002ihe.2_5'UTR|DBF4B_uc010wjc.1_5'UTR|DBF4B_uc002ihg.2_5'UTR	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	11					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				ACGATTGCCTCGAGCTGGAGA	0.562													102	244					0	0	0	0	T	42786685	T	T	42786685	2	4	246	1	0	0	0	0	0	0	0	1	4266	871	31	1		1	DBF4B	17	42786685	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	1973983	42786685	38408525	170	45233											
TMC8	147138	broad.mit.edu	37	chr17	76134712	76134712	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tactcagcaccctggcaagtGgtcccggagctggtggccct	6	8	13	14	1	1	0	1	0	0	0	2	1	2	1	3	5	3	3	3	5	2	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:76134712G>A	uc002jup.2	+	14	2104	c.1722G>A	c.(1720-1722)GTG>GTA	p.V574V	TMC8_uc002juq.2_Silent_p.V351V|TMC8_uc002jur.1_Nonsense_Mutation_p.W24*	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	574	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			CCTGGCAAGTGGTCCCGGAGC	0.657									Epidermodysplasia_Verruciformis_Familial_Clustering_of				27	75					0	0	0	0	A	76134712	A	A	76134712	2	1	246	1	0	0	0	0	0	0	0	1	16057	1335	47	4		4	TMC8	17	76134712	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	33348027	76134712	5060498	171	45234											
RPTOR	57521	broad.mit.edu	37	chr17	78882729	78882729	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaacagcatcgcctacaaGgtacgtgccgggcgctcccc	8	6	10	17	4	1	0	1	0	0	0	3	0	2	0	4	2	5	3	4	2	4	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:78882729G>A	uc002jyt.1	+	21	3325	c.2520G>A	c.(2518-2520)AAG>AAA	p.K840K	RPTOR_uc010wug.1_Silent_p.K682K	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	840					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						TCGCCTACAAGGTACGTGCCG	0.587													35	103					0	0	0	0	A	78882729	A	A	78882729	2	1	246	1	0	0	0	0	0	0	0	1	13730	1014	35	4		4	RPTOR	17	78882729	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	2748017	78882729	2312481	172	45235											
TBCD	6904	broad.mit.edu	37	chr17	80863819	80863819	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtctcttgcagtcttcccGaggctgctgtccatgacact	5	13	9	14	1	2	1	0	1	2	0	5	2	4	1	2	1	2	3	2	1	0	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr17:80863819G>A	uc002kfz.2	+	20	1942	c.1812G>A	c.(1810-1812)CCG>CCA	p.P604P	TBCD_uc002kfx.1_Silent_p.P587P|TBCD_uc002kfy.1_Silent_p.P604P|TBCD_uc002kgb.1_5'UTR	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	604	HEAT 3.				'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CAGTCTTCCCGAGGCTGCTGT	0.607													8	10					0	0	0	0	A	80863819	A	A	80863819	2	1	246	1	0	0	0	0	0	0	0	1	15699	1045	37	1		1	TBCD	17	80863819	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1981090	80863819	331391	173	45236											
USP14	9097	broad.mit.edu	37	chr18	202939	202939	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaagaaatgccttgtatatCaaatctgtaagttatgcagt	15	13	7	6	0	2	1	1	0	1	1	2	1	2	1	1	0	2	4	1	0	7	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:202939C>T	uc002kkf.1	+	11	1152	c.936C>T	c.(934-936)ATC>ATT	p.I312I	USP14_uc002kkg.1_Silent_p.I277I|USP14_uc010wyr.1_Silent_p.I301I	NM_005151	NP_005142	P54578	UBP14_HUMAN	ubiquitin specific protease 14 isoform a	312					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)	2		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				CCTTGTATATCAAATCTGTAA	0.333													11	33					0	0	0	0	T	202939	T	T	202939	2	4	246	1	0	0	0	0	0	0	0	1	17113	816	29	2		2	USP14	18	202939	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08		202939	77874309	174	45237											
DLGAP1	9229	broad.mit.edu	37	chr18	3880020	3880020	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagcgagtcacaggccgagtCgcaggtgaccccgtggtgat	8	6	15	12	4	1	2	1	2	0	0	2	4	1	2	3	3	1	1	3	3	0	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:3880020C>T	uc002kmf.2	-	1	116	c.49G>A	c.(49-51)GAC>AAC	p.D17N	DLGAP1_uc010wyz.1_Missense_Mutation_p.D17N|DLGAP1_uc002kmk.2_Missense_Mutation_p.D17N|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	17					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CAGGCCGAGTCGCAGGTGACC	0.662													14	29					0	0	0	0	T	3880020	T	T	3880020	3	4	246	1	0	0	0	0	1	0	0	0	4581	884	31	1	2979	1	DLGAP1	18	3880020	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	3677081	3880020	74197228	175	45238											
ASXL3	80816	broad.mit.edu	37	chr18	31325297	31325297	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcgagaaaaccaccccaaaAagagagtagctaggactgta	18	4	10	9	1	0	2	0	0	0	2	0	5	0	3	3	1	3	3	3	1	7	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:31325297A>C	uc010dmg.1	+	12	5540	c.5485A>C	c.(5485-5487)AAG>CAG	p.K1829Q	ASXL3_uc002kxq.2_Missense_Mutation_p.K1536Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1829					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CCACCCCAAAAAGAGAGTAGC	0.483													44	173					0	0	0	0	C	31325297	C	C	31325297	3	2	246	1	0	0	0	0	1	0	0	0	1070	15	1	5	5531	5	ASXL3	18	31325297	Missense_Mutation	SNP	A	TCGA-CV-7406-01A-11D-2078-08	27445277	31325297	46751951	176	45239											
SMAD4	4089	broad.mit.edu	37	chr18	48584814	48584814	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acccgcctatgccgccccatCccggacattactgtaagctc	8	8	7	18	3	0	0	0	0	0	0	2	1	1	1	6	1	3	2	6	1	3	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:48584814C>T	uc010xdp.1	+	7	1430	c.892C>T	c.(892-894)CCC>TCC	p.P298S	SMAD4_uc002lfb.3_Missense_Mutation_p.P143S	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	298	SAD.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GCCGCCCCATCCCGGACATTA	0.428									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				20	79					0	0	0	0	T	48584814	T	T	48584814	3	4	246	1	0	0	0	0	1	0	0	0	14824	855	30	2	914	2	SMAD4	18	48584814	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	17259517	48584814	29492434	177	45240											
FECH	2235	broad.mit.edu	37	chr18	55221509	55221509	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacctccttggctaaaacttGagagtactcgatgtccagct	10	12	8	11	1	0	1	0	1	0	1	3	3	2	1	3	1	4	3	3	1	4	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:55221509G>C	uc002lgq.3	-	9	1177	c.1060C>G	c.(1060-1062)CAA>GAA	p.Q354E	FECH_uc002lgp.3_Missense_Mutation_p.Q360E|FECH_uc002lgr.3_Missense_Mutation_p.Q212E	NM_000140	NP_000131	P22830	HEMH_HUMAN	ferrochelatase isoform b precursor	354					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding	p.L354L(1)		central_nervous_system(1)	1		Colorectal(73;0.227)				GCTAAAACTTGAGAGTACTCG	0.413													55	224					0	0	0	0	C	55221509	C	C	55221509	3	2	246	1	0	0	0	0	1	0	0	0	5840	1299	45	2	223	2	FECH	18	55221509	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	6636695	55221509	22855739	178	45241											
CCBE1	147372	broad.mit.edu	37	chr18	57147439	57147439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgggatgcattgtccaaGaacaaatttatatcctttgc	11	15	7	8	0	1	1	0	0	1	1	3	2	3	2	2	1	3	1	2	1	5	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:57147439G>A	uc002lib.2	-	3	314	c.244C>T	c.(244-246)CTT>TTT	p.L82F		NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	82					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				CATTGTCCAAGAACAAATTTA	0.284													27	24					0	0	0	0	A	57147439	A	A	57147439	3	1	246	1	0	0	0	0	1	0	0	0	2743	942	33	2	1012	2	CCBE1	18	57147439	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1925930	57147439	20929809	179	45242											
SERPINB12	89777	broad.mit.edu	37	chr18	61234050	61234050	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtcccaatttgtacttgTcaaaaattatccacaaaacc	16	11	3	11	0	1	0	1	0	0	0	3	0	3	0	3	0	2	1	3	0	8	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:61234050T>C	uc010xen.1	+	7	1024	c.1024T>C	c.(1024-1026)TCA>CCA	p.S342P	SERPINB12_uc010xeo.1_Missense_Mutation_p.S362P	NM_080474	NP_536722	Q96P63	SPB12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	342					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity				0						TTTGTACTTGTCAAAAATTAT	0.448													32	136					0	0	0	0	C	61234050	C	C	61234050	3	2	246	1	0	0	0	0	1	0	0	0	14164	1667	58	5	1050	5	SERPINB12	18	61234050	Missense_Mutation	SNP	T	TCGA-CV-7406-01A-11D-2078-08	4086611	61234050	16843198	180	45243											
SERPINB2	5055	broad.mit.edu	37	chr18	61562580	61562581	+	Frame_Shift_Del	DEL	AG	-	-																															cagctgtgggttcatgcagcAgatccagaagggtagttatc																								rs149564761	byFrequency	TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr18:61562580_61562581delAG	uc010xeu.1	+	4	584_585	c.251_252delAG	c.(250-252)CAGfs	p.Q84fs	SERPINB2_uc002ljo.2_Frame_Shift_Del_p.Q84fs|SERPINB2_uc010dqh.2_Frame_Shift_Del_p.Q14fs|SERPINB2_uc002ljp.1_5'Flank|SERPINB2_uc002ljq.1_5'Flank	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	84					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	TTCATGCAGCAGATCCAGAAGG	0.416													---	---	---								-	61562581	-	-	61562580	7	5	246	1	0	1	0	1	0	0	0	0	14166	188	7	0	257	0	SERPINB2	18	61562580	Frame_Shift_Del	DEL	AG	TCGA-CV-7406-01A-11D-2078-08	328530	61562580	16514668	181	45244											
CREB3L3	84699	broad.mit.edu	37	chr19	4171739	4171739	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggccccaggaccccgacccGaggctgacacaacccgagaa	12	1	11	17	3	0	2	0	1	0	1	0	6	0	3	6	3	1	1	6	3	2	0	rs142789769		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:4171739G>A	uc002lzl.2	+	10	1275	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	CREB3L3_uc002lzm.2_Missense_Mutation_p.E377K|CREB3L3_uc010xib.1_Missense_Mutation_p.E376K|CREB3L3_uc010xic.1_3'UTR	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	387	Lumenal (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCCGACCCGAGGCTGACAC	0.632													42	76					0	0	0	0	A	4171739	A	A	4171739	3	1	246	1	0	0	0	0	1	0	0	0	3873	1059	37	1	1197	1	CREB3L3	19	4171739	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08		4171739	54957244	182	45245											
MYO1F	4542	broad.mit.edu	37	chr19	8619446	8619446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagatgtgcgggggattctCatactgggcctggcagggga	7	9	18	7	1	1	1	1	0	1	1	2	3	1	3	1	6	2	2	1	6	2	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:8619446C>T	uc002mkg.2	-	4	355	c.241G>A	c.(241-243)GAG>AAG	p.E81K	MYO1F_uc002mkh.2_Missense_Mutation_p.E81K|MYO1F_uc010xkf.1_Missense_Mutation_p.E81K	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	81	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GGGGGATTCTCATACTGGGCC	0.617													23	47					0	0	0	0	T	8619446	T	T	8619446	3	4	246	1	0	0	0	0	1	0	0	0	10126	835	29	2	3155	2	MYO1F	19	8619446	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	4447707	8619446	50509537	183	45246											
MUC16	94025	broad.mit.edu	37	chr19	9024166	9024166	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagggaggatggagtccctGaggttctgagatccactgtg	9	9	16	7	0	1	3	0	2	1	2	3	7	3	6	2	4	0	1	2	4	0	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:9024166G>A	uc002mkp.2	-	18	37310	c.37106C>T	c.(37105-37107)TCA>TTA	p.S12369L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12371	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGAGTCCCTGAGGTTCTGAG	0.473													5	14					0	0	0	0	A	9024166	A	A	9024166	3	1	246	1	0	0	0	0	1	0	0	0	10026	1294	45	2	6685	2	MUC16	19	9024166	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	404720	9024166	50104817	184	45247											
MUC16	94025	broad.mit.edu	37	chr19	9056817	9056817	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggaggccagtctggggatGatgtttttgcagaagaggtg	8	11	17	5	0	1	3	0	1	1	2	1	5	1	5	1	5	1	2	1	5	1	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:9056817G>A	uc002mkp.2	-	3	30833	c.30629C>T	c.(30628-30630)TCA>TTA	p.S10210L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10212	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCTGGGGATGATGTTTTTGC	0.468													11	48					0	0	0	0	A	9056817	A	A	9056817	3	1	246	1	0	0	0	0	1	0	0	0	10026	1294	45	2	13222	2	MUC16	19	9056817	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	32651	9056817	50072166	185	45248											
SMARCA4	6597	broad.mit.edu	37	chr19	11135091	11135091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaagggcgtgctgctgactGatggctccgagaaggacaag	10	6	15	10	2	0	3	0	2	0	1	1	5	1	4	2	3	2	3	2	3	3	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:11135091G>A	uc002mqf.3	+	21	3342	c.3058G>A	c.(3058-3060)GAT>AAT	p.D1020N	SMARCA4_uc010dxp.2_Missense_Mutation_p.D1020N|SMARCA4_uc010dxo.2_Missense_Mutation_p.D1020N|SMARCA4_uc002mqg.1_Missense_Mutation_p.D1020N|SMARCA4_uc010dxq.2_Missense_Mutation_p.D1020N|SMARCA4_uc010dxr.2_Missense_Mutation_p.D1020N|SMARCA4_uc002mqj.3_Missense_Mutation_p.D1020N|SMARCA4_uc010dxs.2_Missense_Mutation_p.D1020N|SMARCA4_uc010dxt.1_Missense_Mutation_p.D240N|SMARCA4_uc002mqh.3_Missense_Mutation_p.D143N|SMARCA4_uc002mqi.1_Missense_Mutation_p.D223N	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1020					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCTGCTGACTGATGGCTCCGA	0.627			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				15	26					0	0	0	0	A	11135091	A	A	11135091	3	1	246	1	0	0	0	0	1	0	0	0	14834	1290	45	2	3136	2	SMARCA4	19	11135091	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	2078274	11135091	47993892	186	45249											
NDUFA13	51079	broad.mit.edu	37	chr19	19637028	19637028	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atagggattggaaccctgatCtacgggcactggagcataat	12	9	12	8	1	1	1	0	1	1	0	1	4	1	4	1	4	3	2	1	4	4	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:19637028C>G	uc010xqy.1	+	2	640	c.381C>G	c.(379-381)ATC>ATG	p.I127M	NDUFA13_uc002nms.2_Missense_Mutation_p.I127M|NDUFA13_uc010xqx.1_Missense_Mutation_p.I127M|YJEFN3_uc002nmt.1_5'Flank|YJEFN3_uc010ecf.1_5'Flank|YJEFN3_uc002nmu.1_5'Flank	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	44	Helical; (Potential).				apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	GAACCCTGATCTACGGGCACT	0.642													6	22					0	0	0	0	G	19637028	G	G	19637028	3	3	246	1	0	0	0	0	1	0	0	0	10317	903	32	2	138	2	NDUFA13	19	19637028	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	8501937	19637028	39491955	187	45250											
ZNF737	100129842	broad.mit.edu	37	chr19	20728762	20728762	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgctctggccaaagatctcGggcaaaatgagaacacgtaa	14	7	10	10	2	2	2	0	1	2	2	3	3	2	2	1	2	2	3	1	2	5	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:20728762G>A	uc002npa.2	-	4	427	c.247C>T	c.(247-249)CGA>TGA	p.R83*		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	83					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CAAAGATCTCGGGCAAAATGA	0.328													3	20					0	0	0	0	A	20728762	A	A	20728762	4	1	246	1	0	0	0	0	0	1	0	0	18193	1124	39	1	1367	1	ZNF737	19	20728762	Nonsense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1091734	20728762	38400221	188	45251											
TSHZ3	57616	broad.mit.edu	37	chr19	31767646	31767646	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acggtgacttggtttgtgctAtctgactgttaatctgttcg	6	17	11	7	2	2	2	0	2	2	0	3	2	2	2	0	2	1	4	0	2	2	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:31767646A>G	uc002nsy.3	-	2	3118	c.3053T>C	c.(3052-3054)ATA>ACA	p.I1018T		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	1018					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GGTTTGTGCTATCTGACTGTT	0.502													17	42					0	0	0	0	G	31767646	G	G	31767646	3	3	246	1	0	0	0	0	1	0	0	0	16692	449	16	5	196	5	TSHZ3	19	31767646	Missense_Mutation	SNP	A	TCGA-CV-7406-01A-11D-2078-08	11038884	31767646	27361337	189	45252											
FCGBP	8857	broad.mit.edu	37	chr19	40354269	40354269	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacatccctcaccatggggaGaagtcctgcgctctccattt	8	11	8	14	1	2	1	1	0	1	1	5	2	4	1	4	2	2	1	4	2	2	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:40354269G>A	uc002omp.3	-	35	16208	c.16200C>T	c.(16198-16200)TTC>TTT	p.F5400F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5400	VWFD 13.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACCATGGGGAGAAGTCCTGCG	0.557													13	61					0	0	0	0	A	40354269	A	A	40354269	2	1	246	1	0	0	0	0	0	0	0	1	5810	933	33	2		2	FCGBP	19	40354269	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	8586623	40354269	18774714	190	45253											
CEACAM5	1048	broad.mit.edu	37	chr19	42221507	42221507	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtaaataatcagagcctcccGgtcagtcccaggctgcagct	10	8	10	13	1	2	1	2	0	0	1	4	1	4	1	3	2	3	4	3	2	3	2	rs149933160		TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:42221507G>A	uc002ork.2	+	5	1213	c.1092G>A	c.(1090-1092)CCG>CCA	p.P364P	CEACAM5_uc002orj.1_Silent_p.P363P|CEACAM5_uc002orl.2_Silent_p.P364P	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	364	Ig-like 4.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		AGAGCCTCCCGGTCAGTCCCA	0.512													29	159					0	0	0	0	A	42221507	A	A	42221507	2	1	246	1	0	0	0	0	0	0	0	1	3210	1103	39	1		1	CEACAM5	19	42221507	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1867238	42221507	16907476	191	45254											
GRIK5	2901	broad.mit.edu	37	chr19	42510941	42510941	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggccgtgtaggaggagatGatgatcaaggtgaaggccca	11	8	16	6	1	1	4	1	3	0	1	1	6	1	5	2	5	0	1	2	5	3	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:42510941G>A	uc002osj.1	-	15	1928	c.1893C>T	c.(1891-1893)ATC>ATT	p.I631I	GRIK5_uc002osi.1_Silent_p.I203I	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	631	Helical; (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	AGGAGGAGATGATGATCAAGG	0.647													8	19					0	0	0	0	A	42510941	A	A	42510941	2	1	246	1	0	0	0	0	0	0	0	1	6816	1280	45	2		2	GRIK5	19	42510941	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	289434	42510941	16618042	192	45255											
IRGC	56269	broad.mit.edu	37	chr19	44222839	44222839	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccaggccgcctctcacctCcaggagctgctggcctccac	5	6	9	21	1	1	0	1	0	1	0	4	1	3	1	8	3	2	2	8	3	0	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:44222839C>A	uc002oxh.2	+	2	276	c.129C>A	c.(127-129)CTC>CTA	p.L43L		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	43						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CCTCTCACCTCCAGGAGCTGC	0.667													34	48					6.53348e-20	7.02761e-20	1	0	A	44222839	A	A	44222839	2	1	246	1	0	0	0	0	0	0	0	1	7877	842	30	2		2	IRGC	19	44222839	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	1711898	44222839	14906144	193	45256											
MARK4	57787	broad.mit.edu	37	chr19	45769536	45769536	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatattgtacacagggacctGaaggtaagcccccgacccgc	12	6	10	13	2	0	1	0	1	0	0	0	3	0	2	4	2	2	2	4	2	5	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:45769536G>A	uc002pbb.1	+	7	551	c.546G>A	c.(544-546)CTG>CTA	p.L182L	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Silent_p.L182L|MARK4_uc002pbc.1_Silent_p.L48L			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	182	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ACAGGGACCTGAAGGTAAGCC	0.562													61	76					0	0	0	0	A	45769536	A	A	45769536	2	1	246	1	0	0	0	0	0	0	0	1	9368	1277	45	2		2	MARK4	19	45769536	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1546697	45769536	13359447	194	45257											
ZNF528	84436	broad.mit.edu	37	chr19	52919487	52919487	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccattttctaatccatagtgGagagaaaccttatgaatgta	14	13	7	7	0	1	2	0	1	1	1	2	4	2	3	3	1	1	1	3	1	6	6			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:52919487G>A	uc002pzh.2	+	7	1808	c.1382G>A	c.(1381-1383)GGA>GAA	p.G461E	ZNF528_uc002pzi.2_Missense_Mutation_p.G228E	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		ATCCATAGTGGAGAGAAACCT	0.378													20	76					0	0	0	0	A	52919487	A	A	52919487	3	1	246	1	0	0	0	0	1	0	0	0	18036	1174	41	2	1396	2	ZNF528	19	52919487	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	7149951	52919487	6209496	195	45258											
MBOAT7	79143	broad.mit.edu	37	chr19	54677887	54677887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtagatggaggcccagtaccGaagggtgtcggccaaggaga	11	5	17	8	2	0	2	0	0	0	2	1	5	0	3	3	5	1	2	3	5	4	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:54677887G>A	uc002qdq.2	-	9	1536	c.1270C>T	c.(1270-1272)CGG>TGG	p.R424W	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Missense_Mutation_p.R108W|MBOAT7_uc010yem.1_Missense_Mutation_p.R406W|MBOAT7_uc002qdr.2_Missense_Mutation_p.R424W|MBOAT7_uc002qds.2_Missense_Mutation_p.R351W|MBOAT7_uc010yen.1_Missense_Mutation_p.R351W	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	424					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCCAGTACCGAAGGGTGTCG	0.647													17	102					0	0	0	0	A	54677887	A	A	54677887	3	1	246	1	0	0	0	0	1	0	0	0	9411	1057	37	1	152	1	MBOAT7	19	54677887	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1758400	54677887	4451096	196	45259											
LILRA5	353514	broad.mit.edu	37	chr19	54819017	54819017	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttgttttgtgacggactGaggttatcagctgctcctga	7	14	12	8	1	1	3	1	3	0	0	2	5	2	4	1	2	2	4	1	2	1	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:54819017G>C	uc002qfe.2	-	6	849	c.729C>G	c.(727-729)CTC>CTG	p.L243L	LILRA5_uc002qff.2_Silent_p.L231L|LILRA5_uc010yev.1_Silent_p.L243L|LILRA5_uc010yew.1_Silent_p.L231L	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	243	Extracellular (Potential).				innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTGACGGACTGAGGTTATCAG	0.507													10	42					0	0	0	0	C	54819017	C	C	54819017	2	2	246	1	0	0	0	0	0	0	0	1	8829	1277	45	2		2	LILRA5	19	54819017	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	141130	54819017	4309966	197	45260											
NLRP13	126204	broad.mit.edu	37	chr19	56422029	56422029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcaggtctagctcatgcaGattctcatttgtgaccaacg	10	12	8	11	1	4	2	3	1	2	1	5	2	4	2	1	1	3	2	1	1	2	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:56422029G>C	uc010ygg.1	-	6	2207	c.2182C>G	c.(2182-2184)CTG>GTG	p.L728V		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	728	LRR 1.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		AGCTCATGCAGATTCTCATTT	0.453													32	97					0	0	0	0	C	56422029	C	C	56422029	3	2	246	1	0	0	0	0	1	0	0	0	10529	933	33	2	971	2	NLRP13	19	56422029	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	1603012	56422029	2706954	198	45261											
ZNF667	63934	broad.mit.edu	37	chr19	56954105	56954105	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttggtctcacatttagaccCcgagtctgaaagacataaag	13	10	8	10	1	2	3	1	1	2	2	3	4	2	3	2	1	0	0	2	1	4	4	rs138160651	byFrequency	TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:56954105C>A	uc002qnd.2	-	5	421	c.259G>T	c.(259-261)GGG>TGG	p.G87W	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_Missense_Mutation_p.G87W|ZNF667_uc010etm.2_Missense_Mutation_p.G30W	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CATTTAGACCCCGAGTCTGAA	0.348													15	77					2.23348e-06	2.31487e-06	1	0	A	56954105	A	A	56954105	3	1	246	1	0	0	0	0	1	0	0	0	18141	623	22	4	1577	4	ZNF667	19	56954105	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	532076	56954105	2174878	199	45262											
ZNF71	58491	broad.mit.edu	37	chr19	57133429	57133429	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agccagaacatgcacctcatCgtgcaccagcgcacgcacac	12	4	8	17	3	1	1	1	0	0	1	2	1	1	1	3	0	5	4	3	0	1	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr19:57133429C>T	uc002qnm.3	+	3	1012	c.774C>T	c.(772-774)ATC>ATT	p.I258I		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	258	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		TGCACCTCATCGTGCACCAGC	0.662													16	48					0	0	0	0	T	57133429	T	T	57133429	2	4	246	1	0	0	0	0	0	0	0	1	18181	874	31	1		1	ZNF71	19	57133429	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	179324	57133429	1995554	200	45263											
TRIB3	57761	broad.mit.edu	37	chr20	372179	372179	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccagcacggtctggtcctGcgtgatctcaagctgtgtcg	6	10	12	13	3	2	1	1	1	2	0	5	1	3	1	2	2	3	2	2	2	1	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr20:372179G>A	uc002wdm.2	+	3	1046	c.540G>A	c.(538-540)CTG>CTA	p.L180L	TRIB3_uc002wdn.2_Silent_p.L207L	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	180	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GTCTGGTCCTGCGTGATCTCA	0.637													8	27					0	0	0	0	A	372179	A	A	372179	2	1	246	1	0	0	0	0	0	0	0	1	16551	1306	46	4		4	TRIB3	20	372179	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08		372179	62653341	201	45264											
C20orf26	26074	broad.mit.edu	37	chr20	20243630	20243630	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctacagaggctgatattagtCaacacctgacaaacagggag	15	7	10	9	0	1	3	1	2	0	1	1	4	1	4	1	2	3	1	1	2	5	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr20:20243630C>G	uc002wru.2	+	21	2435	c.2359C>G	c.(2359-2361)CAA>GAA	p.Q787E	C20orf26_uc010zse.1_Missense_Mutation_p.Q767E|C20orf26_uc002wrw.2_RNA|C20orf26_uc002wrv.2_Missense_Mutation_p.Q143E	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	787										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		TGATATTAGTCAACACCTGAC	0.443													12	31					0	0	0	0	G	20243630	G	G	20243630	3	3	246	1	0	0	0	0	1	0	0	0	2116	827	29	2	2469	2	C20orf26	20	20243630	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	19871451	20243630	42781890	202	45265											
GINS1	9837	broad.mit.edu	37	chr20	25405913	25405913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtcactgggaggagatgaaGgtttggacattacacaggat	12	9	15	5	0	1	2	1	1	0	1	1	6	1	5	0	6	1	1	0	6	2	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr20:25405913G>A	uc002wuv.1	+	5	531	c.397G>A	c.(397-399)GGT>AGT	p.G133S	GINS1_uc010zte.1_RNA	NM_021067	NP_066545	Q14691	PSF1_HUMAN	GINS complex subunit 1	133					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm		p.G133R(1)		ovary(1)|central_nervous_system(1)	2						AGGAGATGAAGGTTTGGACAT	0.313													3	38					0	0	0	0	A	25405913	A	A	25405913	3	1	246	1	0	0	0	0	1	0	0	0	6424	1000	35	4	415	4	GINS1	20	25405913	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	5162283	25405913	37619607	203	45266											
RBL1	5933	broad.mit.edu	37	chr20	35668562	35668562	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatgttgaacctacctcttcGaagactcccactgtcagttc	10	12	6	13	1	2	2	1	1	1	1	5	3	3	2	3	0	2	2	3	0	4	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr20:35668562G>A	uc002xgi.2	-	14	1976	c.1897C>T	c.(1897-1899)CGA>TGA	p.R633*	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Nonsense_Mutation_p.R633*	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	633	Pocket; binds T and E1A.|Spacer.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				CTACCTCTTCGAAGACTCCCA	0.413													33	83					0	0	0	0	A	35668562	A	A	35668562	4	1	246	1	0	0	0	0	0	1	0	0	13174	1066	37	1	1354	1	RBL1	20	35668562	Nonsense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	10262649	35668562	27356958	204	45267											
SLC13A3	64849	broad.mit.edu	37	chr20	45221110	45221110	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacaggaacaacagcataaGagggaaggcgaaaatgaacc	20	2	11	8	1	0	2	0	1	0	1	0	5	0	4	1	3	5	1	1	3	8	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr20:45221110G>C	uc002xsf.1	-	6	891	c.853C>G	c.(853-855)CTT>GTT	p.L285V	SLC13A3_uc010ghn.1_Missense_Mutation_p.L254V|SLC13A3_uc010zxw.1_Intron|SLC13A3_uc002xsg.1_Missense_Mutation_p.L238V|SLC13A3_uc010gho.1_Missense_Mutation_p.L238V|SLC13A3_uc010zxx.1_Missense_Mutation_p.L187V	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	285	Helical; (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	AACAGCATAAGAGGGAAGGCG	0.522													7	27					0	0	0	0	C	45221110	C	C	45221110	3	2	246	1	0	0	0	0	1	0	0	0	14458	942	33	2	987	2	SLC13A3	20	45221110	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	9552548	45221110	17804410	205	45268											
UMODL1	89766	broad.mit.edu	37	chr21	43547845	43547845	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aactccaataaggcccagttCaagctgaggatcttttcctt	11	12	7	11	0	2	1	1	1	1	0	4	2	4	2	3	2	2	2	3	2	4	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr21:43547845C>T	uc002zaf.1	+	20	3594	c.3594C>T	c.(3592-3594)TTC>TTT	p.F1198F	UMODL1_uc002zad.1_Silent_p.F1126F|UMODL1_uc002zae.1_Silent_p.F1254F|UMODL1_uc002zag.1_Silent_p.F1326F|UMODL1_uc002zal.1_Silent_p.F148F|UMODL1_uc010gpa.1_RNA	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	1198	Extracellular (Potential).|ZP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						AGGCCCAGTTCAAGCTGAGGA	0.517													12	47					0	0	0	0	T	43547845	T	T	43547845	2	4	246	1	0	0	0	0	0	0	0	1	17048	825	29	2		2	UMODL1	21	43547845	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08		43547845	4582050	206	45269											
C22orf43	51233	broad.mit.edu	37	chr22	23974134	23974134	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcataaatatcagtatcaGattcataacagggtgcgtcc	13	12	7	9	1	4	1	4	0	1	1	6	1	5	1	1	1	2	1	1	1	5	5			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr22:23974134G>A	uc002zxf.2	-	1	354	c.77C>T	c.(76-78)TCT>TTT	p.S26F		NM_016449	NP_057533	Q6PGQ1	CV043_HUMAN	hypothetical protein LOC51233	26										skin(1)	1						ATCAGTATCAGATTCATAACA	0.542													26	66					0	0	0	0	A	23974134	A	A	23974134	3	1	246	1	0	0	0	0	1	0	0	0	2160	942	33	2	660	2	C22orf43	22	23974134	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08		23974134	27330432	207	45270											
CABIN1	23523	broad.mit.edu	37	chr22	24483605	24483605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgtcctatgccttgcactCattcgcctcacgtcaattga	8	13	6	14	2	3	1	3	1	0	0	5	1	4	1	3	0	2	1	3	0	2	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr22:24483605C>T	uc002zzi.1	+	23	3591	c.3464C>T	c.(3463-3465)TCA>TTA	p.S1155L	CABIN1_uc002zzj.1_Missense_Mutation_p.S1105L|CABIN1_uc002zzl.1_Missense_Mutation_p.S1155L	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1155					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GCCTTGCACTCATTCGCCTCA	0.587													23	60					0	0	0	0	T	24483605	T	T	24483605	3	4	246	1	0	0	0	0	1	0	0	0	2540	838	29	2	3550	2	CABIN1	22	24483605	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	509471	24483605	26820961	208	45271											
TBC1D10A	83874	broad.mit.edu	37	chr22	30722748	30722748	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttggcctccgagtcagacccGagagagctgagttcgtcggt	7	9	14	11	4	1	3	1	1	0	2	4	6	2	3	3	2	1	2	3	2	0	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chr22:30722748G>A	uc011akt.1	-	1	147	c.123C>T	c.(121-123)CTC>CTT	p.L41L	TBC1D10A_uc010gvu.2_Silent_p.L41L|TBC1D10A_uc003ahk.3_Silent_p.L41L	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	41						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						AGTCAGACCCGAGAGAGCTGA	0.607													12	34					0	0	0	0	A	30722748	A	A	30722748	2	1	246	1	0	0	0	0	0	0	0	1	15664	1045	37	1		1	TBC1D10A	22	30722748	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	6239143	30722748	20581818	209	45272											
SYAP1	94056	broad.mit.edu	37	chrX	16775366	16775366	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgtaacctaaatcaggaaGatctaaggaaagaaatggag	18	7	10	6	0	2	2	1	0	1	2	2	5	2	5	2	3	1	1	2	3	7	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:16775366G>A	uc004cxp.2	+	8	958	c.865G>A	c.(865-867)GAT>AAT	p.D289N	SYAP1_uc004cxo.2_Missense_Mutation_p.D289N|SYAP1_uc011miv.1_Missense_Mutation_p.D255N	NM_032796	NP_116185	Q96A49	SYAP1_HUMAN	SYAP1 protein	289										skin(1)	1	Hepatocellular(33;0.0997)					AAATCAGGAAGATCTAAGGAA	0.398													39	29					0	0	0	0	A	16775366	A	A	16775366	3	1	246	1	0	0	0	0	1	0	0	0	15492	942	33	2	895	2	SYAP1	23	16775366	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08		16775366	138495194	210	45273											
TAB3	257397	broad.mit.edu	37	chrX	30873379	30873379	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaaaaatggattgtagttggGagtagcagcaacaacagctg	16	8	12	5	0	0	0	0	0	0	0	0	2	0	2	0	2	5	6	0	2	7	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:30873379G>A	uc004dcj.2	-	6	1066	c.403C>T	c.(403-405)CCC>TCC	p.P135S	TAB3_uc004dck.2_Missense_Mutation_p.P135S|TAB3_uc010ngl.2_Missense_Mutation_p.P135S	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	135					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						TTGTAGTTGGGAGTAGCAGCA	0.443													28	15					0	0	0	0	A	30873379	A	A	30873379	3	1	246	1	0	0	0	0	1	0	0	0	15563	1174	41	2	1759	2	TAB3	23	30873379	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	14098013	30873379	124397181	211	45274											
GATA1	2623	broad.mit.edu	37	chrX	48650432	48650432	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcagcaccagcttcctggaGactttgaagacagagcggct	10	7	13	11	1	0	4	0	1	0	3	1	5	1	4	2	3	3	4	2	3	1	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:48650432G>A	uc004dkq.3	+	3	493	c.402G>A	c.(400-402)GAG>GAA	p.E134E		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	134					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V74_C199del(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						GCTTCCTGGAGACTTTGAAGA	0.612			Mis|F		megakaryoblastic leukemia of Downs Syndrome								15	14					0	0	0	0	A	48650432	A	A	48650432	2	1	246	1	0	0	0	0	0	0	0	1	6288	933	33	2		2	GATA1	23	48650432	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	17777053	48650432	106620128	212	45275											
KCND1	3750	broad.mit.edu	37	chrX	48826593	48826593	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgccttcacccccggtgccGggggcaggggttgctgggcc	3	7	17	14	2	1	0	1	0	0	0	1	0	1	0	5	6	3	3	5	6	0	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:48826593G>A	uc004dlx.1	-	1	1659	c.86C>T	c.(85-87)CCG>CTG	p.P29L	KCND1_uc004dlw.1_5'Flank	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	29	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						CCCCGGTGCCGGGGGCAGGGG	0.662													3	8					0	0	0	0	A	48826593	A	A	48826593	3	1	246	1	0	0	0	0	1	0	0	0	8057	1116	39	1	1881	1	KCND1	23	48826593	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	176161	48826593	106443967	213	45276											
HUWE1	10075	broad.mit.edu	37	chrX	53560990	53560990	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgtgagctgaaggcaggcGatctgtggacctgtcatctc	7	11	14	9	1	3	2	1	2	2	0	4	4	3	3	1	3	1	2	1	3	1	0			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:53560990G>A	uc004dsp.2	-	83	13402	c.13000C>T	c.(13000-13002)CGC>TGC	p.R4334C	HUWE1_uc004dsn.2_Missense_Mutation_p.R3142C	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4334	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GAAGGCAGGCGATCTGTGGAC	0.493													23	19					0	0	0	0	A	53560990	A	A	53560990	3	1	246	1	0	0	0	0	1	0	0	0	7500	1058	37	1	132	1	HUWE1	23	53560990	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	4734397	53560990	101709570	214	45277											
ITM2A	9452	broad.mit.edu	37	chrX	78616833	78616833	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attagttacttacccagcaaGaggtctctgcgacgaaggcg	11	9	11	10	3	1	1	0	0	1	1	2	3	1	1	1	2	4	2	1	2	5	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:78616833G>A	uc004edh.2	-	5	1031	c.696C>T	c.(694-696)CTC>CTT	p.L232L	ITM2A_uc011mqr.1_Silent_p.L188L	NM_004867	NP_004858	O43736	ITM2A_HUMAN	integral membrane protein 2A	232						integral to membrane	protein binding			lung(2)	2						TACCCAGCAAGAGGTCTCTGC	0.433													31	25					0	0	0	0	A	78616833	A	A	78616833	2	1	246	1	0	0	0	0	0	0	0	1	7951	929	33	2		2	ITM2A	23	78616833	Silent	SNP	G	TCGA-CV-7406-01A-11D-2078-08	25055843	78616833	76653727	215	45278											
TRMT2B	79979	broad.mit.edu	37	chrX	100290613	100290613	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccattttacctgcgccacttGactgtgtttctcagggatgt	6	15	9	11	1	1	1	1	1	1	0	2	2	1	2	3	1	2	1	3	1	1	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:100290613G>C	uc004egq.2	-	6	897	c.598C>G	c.(598-600)CAA>GAA	p.Q200E	TRMT2B_uc004egp.2_RNA|TRMT2B_uc004egr.2_Missense_Mutation_p.Q200E|TRMT2B_uc004egs.2_Missense_Mutation_p.Q200E|TRMT2B_uc004egt.2_Missense_Mutation_p.Q200E|TRMT2B_uc004egu.2_Missense_Mutation_p.Q81E|TRMT2B_uc004egv.2_Missense_Mutation_p.Q155E	NM_024917	NP_079193	Q96GJ1	TRM2_HUMAN	TRM2 tRNA methyltransferase 2 homolog B	200							tRNA (uracil-5-)-methyltransferase activity			ovary(1)	1						TGCGCCACTTGACTGTGTTTC	0.393													24	31					0	0	0	0	C	100290613	C	C	100290613	3	2	246	1	0	0	0	0	1	0	0	0	16633	1299	45	2	948	2	TRMT2B	23	100290613	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	21673780	100290613	54979947	216	45279											
GPRASP2	114928	broad.mit.edu	37	chrX	101971015	101971015	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagggtggagcttcagcaatCtgtgaatctgagccaggaac	11	8	14	8	0	3	2	1	2	2	0	3	5	3	4	1	3	4	2	1	3	3	1			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:101971015C>G	uc004ejk.2	+	4	2552	c.1218C>G	c.(1216-1218)ATC>ATG	p.I406M	GPRASP2_uc004ejl.2_Missense_Mutation_p.I406M|GPRASP2_uc004ejm.2_Missense_Mutation_p.I406M|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	406						cytoplasm	protein binding			ovary(1)	1						CTTCAGCAATCTGTGAATCTG	0.547													3	37					0	0	0	0	G	101971015	G	G	101971015	3	3	246	1	0	0	0	0	1	0	0	0	6762	903	32	2	1220	2	GPRASP2	23	101971015	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	1680402	101971015	53299545	217	45280											
ELF4	2000	broad.mit.edu	37	chrX	129205093	129205093	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acagcttggacacagctttgGagtccaccagtttgaagatg	11	10	11	9	0	0	2	0	1	0	1	1	4	1	4	2	2	2	3	2	2	1	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:129205093G>C	uc004evd.3	-	7	1116	c.731C>G	c.(730-732)TCC>TGC	p.S244C	ELF4_uc004eve.3_Missense_Mutation_p.S244C	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	244	ETS.				natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CACAGCTTTGGAGTCCACCAG	0.522			T	ERG	AML								63	40					0	0	0	0	C	129205093	C	C	129205093	3	2	246	1	0	0	0	0	1	0	0	0	5080	1174	41	2	1272	2	ELF4	23	129205093	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	27234078	129205093	26065467	218	45281											
ARHGAP36	158763	broad.mit.edu	37	chrX	130220635	130220635	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcaaagcaagccttctgaTgaaggtcagttccctgctgg	9	10	11	11	0	3	2	2	2	1	0	4	2	4	2	2	2	3	4	2	2	3	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:130220635T>A	uc004evz.2	+	11	1827	c.1482T>A	c.(1480-1482)GAT>GAA	p.D494E	ARHGAP36_uc004ewa.2_Missense_Mutation_p.D482E|ARHGAP36_uc004ewb.2_Missense_Mutation_p.D463E|ARHGAP36_uc004ewc.2_Missense_Mutation_p.D358E	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	494					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						AGCCTTCTGATGAAGGTCAGT	0.537													7	32					0	0	0	0	A	130220635	A	A	130220635	3	1	246	1	0	0	0	0	1	0	0	0	883	1461	51	5	1520	5	ARHGAP36	23	130220635	Missense_Mutation	SNP	T	TCGA-CV-7406-01A-11D-2078-08	1015542	130220635	25049925	219	45282											
GPC4	2239	broad.mit.edu	37	chrX	132440099	132440099	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcatgttcataatagcatCagaaatcttcacatcgatgg	13	12	7	9	1	4	1	3	0	1	1	5	2	4	1	0	1	2	3	0	1	3	4			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:132440099C>T	uc004exc.1	-	5	1173	c.961G>A	c.(961-963)GAT>AAT	p.D321N	GPC4_uc011mvg.1_Missense_Mutation_p.D251N	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	321					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					ATAATAGCATCAGAAATCTTC	0.488													41	35					0	0	0	0	T	132440099	T	T	132440099	3	4	246	1	0	0	0	0	1	0	0	0	6638	826	29	2	729	2	GPC4	23	132440099	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	2219464	132440099	22830461	220	45283											
GPC3	2719	broad.mit.edu	37	chrX	132795857	132795857	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aactggtttttcattccattCcttgctgccttttggctgta	5	19	7	10	0	1	0	1	0	0	0	3	0	3	0	3	2	3	4	3	2	2	8			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:132795857C>T	uc004exe.1	-	6	1504	c.1314G>A	c.(1312-1314)AGG>AGA	p.R438R	GPC3_uc004exd.1_Silent_p.R310R|GPC3_uc010nrn.1_Silent_p.R461R|GPC3_uc011mvh.1_Silent_p.R422R|GPC3_uc010nro.1_Silent_p.R384R	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	438						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					TCATTCCATTCCTTGCTGCCT	0.413			T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				15	23					0	0	0	0	T	132795857	T	T	132795857	2	4	246	1	0	0	0	0	0	0	0	1	6637	854	30	2		2	GPC3	23	132795857	Silent	SNP	C	TCGA-CV-7406-01A-11D-2078-08	355758	132795857	22474703	221	45284											
MAGEC2	51438	broad.mit.edu	37	chrX	141291674	141291674	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaggcttcctcctcttcctCatctgtgggatgctgtgcat	4	14	11	12	0	3	0	1	0	2	0	6	2	6	2	3	3	2	3	3	3	0	2			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:141291674C>T	uc004fbu.1	-	3	448	c.100G>A	c.(100-102)GAG>AAG	p.E34K		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	34	Poly-Glu.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCTTCCTCATCTGTGGGA	0.522										HNSCC(46;0.14)			45	41					0	0	0	0	T	141291674	T	T	141291674	3	4	246	1	0	0	0	0	1	0	0	0	9234	835	29	2	1025	2	MAGEC2	23	141291674	Missense_Mutation	SNP	C	TCGA-CV-7406-01A-11D-2078-08	8495817	141291674	13978886	222	45285											
HCFC1	3054	broad.mit.edu	37	chrX	153215717	153215717	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcagccacctcacttgtgtgGccgggccatagcccttctca	6	9	10	16	1	2	0	2	0	1	0	3	0	2	0	5	2	2	1	5	2	1	3			TCGA-CV-7406-01A-11D-2078-08	TCGA-CV-7406-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c9effa8-acb6-4db0-874a-8f0df386924c	b00b903e-f57c-4c6c-b6b8-ae40489e6167	g.chrX:153215717G>A	uc004fjp.2	-	24	6509	c.5981C>T	c.(5980-5982)GCC>GTC	p.A1994V		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1994					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CACTTGTGTGGCCGGGCCATA	0.622													26	11					0	0	0	0	A	153215717	A	A	153215717	3	1	246	1	0	0	0	0	1	0	0	0	7030	1203	42	4	138	4	HCFC1	23	153215717	Missense_Mutation	SNP	G	TCGA-CV-7406-01A-11D-2078-08	11924043	153215717	2054843	223	45286											
PLEKHM2	23207	broad.mit.edu	37	chr1	16059015	16059015	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accgagccgggcaaggagtaCtgcgtcttggtgagctttga	8	9	15	9	3	1	2	0	2	1	0	1	4	1	3	2	3	4	3	2	3	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:16059015C>G	uc010obo.1	+	18	3023	c.2796C>G	c.(2794-2796)TAC>TAG	p.Y932*		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	932					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GCAAGGAGTACTGCGTCTTGG	0.632													8	8					0	0	0	0	G	16059015	G	G	16059015	4	3	247	1	0	0	0	0	0	1	0	0	12136	576	20	4	2866	4	PLEKHM2	1	16059015	Nonsense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08		16059015	233191606	1	45287											
COL24A1	255631	broad.mit.edu	37	chr1	86361734	86361734	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggccctctttttccttgAtctcctttttcaccctaaca	6	17	4	14	0	3	2	1	2	2	0	5	2	4	2	4	1	1	0	4	1	1	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:86361734A>G	uc001dlj.2	-	30	2889	c.2847T>C	c.(2845-2847)GAT>GAC	p.D949D	COL24A1_uc001dli.2_Silent_p.D85D|COL24A1_uc010osd.1_Silent_p.D249D|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	949	Collagen-like 8.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTTTTCCTTGATCTCCTTTTT	0.318													10	26					0	0	0	0	G	86361734	G	G	86361734	2	3	247	1	0	0	0	0	0	0	0	1	3698	330	12	5		5	COL24A1	1	86361734	Silent	SNP	A	TCGA-CV-7407-01A-11D-2078-08	70302719	86361734	162888887	2	45288											
LRRC8D	55144	broad.mit.edu	37	chr1	90400516	90400516	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaactcttggtactgaacaGccttaagaaaatgatgaatg	16	11	8	6	0	1	4	0	3	1	1	1	4	1	4	1	1	4	1	1	1	8	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:90400516G>C	uc001dnm.2	+	3	2314	c.1889G>C	c.(1888-1890)AGC>ACC	p.S630T	LRRC8D_uc001dnn.2_Missense_Mutation_p.S630T	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	630	LRR 5.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GTACTGAACAGCCTTAAGAAA	0.418													6	65					0	0	0	0	C	90400516	C	C	90400516	3	2	247	1	0	0	0	0	1	0	0	0	9074	971	34	4	1891	4	LRRC8D	1	90400516	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	4038782	90400516	158850105	3	45289											
PSMB4	5692	broad.mit.edu	37	chr1	151373789	151373789	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcgacttagtagaacgctgCatgcgagtgctgtactaccg	9	9	12	11	5	0	1	0	0	0	1	0	3	0	1	1	0	6	5	1	0	5	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:151373789C>A	uc001eyc.1	+	5	674	c.651C>A	c.(649-651)TGC>TGA	p.C217*	PSMB4_uc010pda.1_3'UTR|PSMB4_uc001eyb.1_3'UTR	NM_002796	NP_002787	P28070	PSB4_HUMAN	proteasome beta 4 subunit	217					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TAGAACGCTGCATGCGAGTGC	0.577													25	146					3.08376e-08	3.41556e-08	1	0	A	151373789	A	A	151373789	4	1	247	1	0	0	0	0	0	1	0	0	12741	718	25	4	669	4	PSMB4	1	151373789	Nonsense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	60973273	151373789	97876832	4	45290											
SMCP	4184	broad.mit.edu	37	chr1	152856943	152856943	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgctgcccagcaaaaggCaatcaatgctgcccaccaca	15	5	7	14	0	1	0	1	0	0	0	1	0	1	0	3	1	5	4	3	1	5	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:152856943C>T	uc001fat.2	+	2	190	c.45C>T	c.(43-45)GGC>GGT	p.G15G		NM_030663	NP_109588	P49901	MCSP_HUMAN	sperm mitochondria-associated cysteine-rich	15	2.|7 X 7 (OR 8) AA approximate repeats.				penetration of zona pellucida|sperm motility	mitochondrial membrane					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGCAAAAGGCAATCAATGCT	0.458													16	48					0	0	0	0	T	152856943	T	T	152856943	2	4	247	1	0	0	0	0	0	0	0	1	14853	697	25	4		4	SMCP	1	152856943	Silent	SNP	C	TCGA-CV-7407-01A-11D-2078-08	1483154	152856943	96393678	5	45291											
PRCC	5546	broad.mit.edu	37	chr1	156756890	156756890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtggggccccttggatgcCtaagcctggggacgactaca	9	7	14	11	1	0	0	0	0	0	0	0	3	0	2	4	5	3	0	4	5	3	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:156756890C>T	uc001fqa.2	+	3	1297	c.1007C>T	c.(1006-1008)CCT>CTT	p.P336L	PRCC_uc001fqb.2_Missense_Mutation_p.P336L	NM_005973	NP_005964	Q92733	PRCC_HUMAN	papillary renal cell carcinoma	336					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	kidney(25)|central_nervous_system(2)	27	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCTTGGATGCCTAAGCCTGGG	0.572			T	TFE3	papillary renal 								89	181					0	0	0	0	T	156756890	T	T	156756890	3	4	247	1	0	0	0	0	1	0	0	0	12509	681	24	4	1017	4	PRCC	1	156756890	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	3899947	156756890	92493731	6	45292											
CD1D	912	broad.mit.edu	37	chr1	158152716	158152716	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccagtcctggccctggccGtctgctgctggtgtgccatg	2	10	13	16	1	1	0	0	0	1	0	2	0	2	0	6	3	3	2	6	3	0	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:158152716G>A	uc001frr.2	+	5	1155	c.656G>A	c.(655-657)CGT>CAT	p.R219H	CD1D_uc009wss.2_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	219	Ig-like.|Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					GGCCCTGGCCGTCTGCTGCTG	0.592													12	95					0	0	0	0	A	158152716	A	A	158152716	3	1	247	1	0	0	0	0	1	0	0	0	2992	1145	40	1	670	1	CD1D	1	158152716	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	1395826	158152716	91097905	7	45293											
ARHGAP30	257106	broad.mit.edu	37	chr1	161018149	161018149	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgaggtggctgtggggctaCctcttccatctcagaagagt	7	11	13	10	0	2	3	1	1	2	2	4	3	3	3	2	4	1	2	2	4	2	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:161018149C>A	uc001fxl.2	-	12	3008	c.2662G>T	c.(2662-2664)GTA>TTA	p.V888L	USF1_uc001fxi.2_5'Flank|USF1_uc001fxj.2_5'Flank|ARHGAP30_uc001fxk.2_Intron|ARHGAP30_uc001fxm.2_Missense_Mutation_p.V734L|ARHGAP30_uc009wtx.2_Missense_Mutation_p.V561L	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	888	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TGTGGGGCTACCTCTTCCATC	0.587													16	34					1.5739e-10	1.78852e-10	1	0	A	161018149	A	A	161018149	3	1	247	1	0	0	0	0	1	0	0	0	879	507	18	4	647	4	ARHGAP30	1	161018149	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	2865433	161018149	88232472	8	45294											
POGK	57645	broad.mit.edu	37	chr1	166818317	166818317	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctgcccgagtggagtgagggGtaccccttctacatggccat	7	9	13	12	1	1	1	0	1	1	0	1	3	1	2	4	4	3	1	4	4	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:166818317G>A	uc001gdt.1	+	5	621	c.501G>A	c.(499-501)GGG>GGA	p.G167G	POGK_uc010ple.1_Silent_p.G82G|POGK_uc010plf.1_Silent_p.G49G	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	167					multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GGAGTGAGGGGTACCCCTTCT	0.577													9	54					0	0	0	0	A	166818317	A	A	166818317	2	1	247	1	0	0	0	0	0	0	0	1	12240	1248	44	4		4	POGK	1	166818317	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	5800168	166818317	82432304	9	45295											
F5	2153	broad.mit.edu	37	chr1	169511310	169511310	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtcttacttgtagagatttAtgtctaactctaggaaactt	11	17	7	6	0	3	1	0	0	3	1	3	3	3	2	0	1	3	1	0	1	6	8			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:169511310A>C	uc001ggg.1	-	13	3163	c.3018T>G	c.(3016-3018)CAT>CAG	p.H1006Q		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1006	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTAGAGATTTATGTCTAACTC	0.463													17	209					0	0	0	0	C	169511310	C	C	169511310	3	2	247	1	0	0	0	0	1	0	0	0	5373	446	16	5	3708	5	F5	1	169511310	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	2692993	169511310	79739311	10	45296											
FMO1	2326	broad.mit.edu	37	chr1	171249964	171249964	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggggatgggtgatcagcCgaatctttgactcgggctac	8	9	16	8	2	2	2	1	2	1	0	3	5	2	3	1	4	2	1	1	4	2	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:171249964C>T	uc009wvz.2	+	6	803	c.667C>T	c.(667-669)CGA>TGA	p.R223*	FMO1_uc010pme.1_Nonsense_Mutation_p.R160*|FMO1_uc001ghl.2_Nonsense_Mutation_p.R223*|FMO1_uc001ghm.2_Nonsense_Mutation_p.R223*|FMO1_uc001ghn.2_Nonsense_Mutation_p.R223*	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	223					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGTGATCAGCCGAATCTTTGA	0.517													3	48					0	0	0	0	T	171249964	T	T	171249964	4	4	247	1	0	0	0	0	0	1	0	0	5986	644	23	1	685	1	FMO1	1	171249964	Nonsense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	1738654	171249964	78000657	11	45297											
SLC26A9	115019	broad.mit.edu	37	chr1	205888028	205888028	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgggcaaagaggactgcGtcatgtatgctgggaaagac	11	7	15	8	1	1	2	1	0	0	2	1	4	1	4	1	3	2	3	1	3	3	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:205888028G>A	uc001hdq.2	-	19	2310	c.2196C>T	c.(2194-2196)GAC>GAT	p.D732D	SLC26A9_uc001hdm.2_5'Flank|SLC26A9_uc001hdn.2_5'Flank|SLC26A9_uc001hdo.2_Silent_p.D400D|SLC26A9_uc001hdp.2_Silent_p.D732D	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	732	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGAGGACTGCGTCATGTATGC	0.522											OREG0014164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	259					0	0	0	0	A	205888028	A	A	205888028	2	1	247	1	0	0	0	0	0	0	0	1	14588	1136	40	1		1	SLC26A9	1	205888028	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	34638064	205888028	43362593	12	45298											
SERTAD4	56256	broad.mit.edu	37	chr1	210415025	210415025	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ataaacaatttgatgaaaagGatccatggagaaattatcat	19	11	7	4	0	1	3	1	2	0	1	2	5	2	4	1	2	1	0	1	2	7	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:210415025G>C	uc001hhy.2	+	4	593	c.414G>C	c.(412-414)AGG>AGC	p.R138S	SERTAD4_uc009xcw.2_Missense_Mutation_p.R138S	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	138	SERTA.						protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TGATGAAAAGGATCCATGGAG	0.428													24	149					0	0	0	0	C	210415025	C	C	210415025	3	2	247	1	0	0	0	0	1	0	0	0	14188	1165	41	2	424	2	SERTAD4	1	210415025	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	4526997	210415025	38835596	13	45299											
ANGEL2	90806	broad.mit.edu	37	chr1	213181634	213181634	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggccgccggcaatgtctaTaaaggtgagagttatcttcc	9	11	11	10	2	2	1	0	1	2	1	3	2	3	1	3	3	0	2	3	3	5	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:213181634T>C	uc001hjz.2	-	3	715	c.560A>G	c.(559-561)TAT>TGT	p.Y187C	ANGEL2_uc010pto.1_Missense_Mutation_p.Y61C|ANGEL2_uc010ptp.1_Missense_Mutation_p.Y61C|ANGEL2_uc001hka.2_Missense_Mutation_p.Y18C|ANGEL2_uc010ptq.1_RNA|ANGEL2_uc001hkb.2_Missense_Mutation_p.Y165C	NM_144567	NP_653168	Q5VTE6	ANGE2_HUMAN	LOC90806 protein	187											0				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		GCAATGTCTATAAAGGTGAGA	0.353													20	77					0	0	0	0	C	213181634	C	C	213181634	3	2	247	1	0	0	0	0	1	0	0	0	609	1406	49	5	1102	5	ANGEL2	1	213181634	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	2766609	213181634	36068987	14	45300											
SIPA1L2	57568	broad.mit.edu	37	chr1	232600688	232600688	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacactttgatactcactaaTccagatgtccacccaatcac	14	10	3	14	0	2	2	2	1	0	1	4	2	4	2	3	0	2	0	3	0	4	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:232600688T>C	uc001hvg.2	-	7	2876	c.2718A>G	c.(2716-2718)GGA>GGG	p.G906G	SIPA1L2_uc001hvf.2_5'Flank	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	906					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TACTCACTAATCCAGATGTCC	0.428													44	43					0	0	0	0	C	232600688	C	C	232600688	2	2	247	1	0	0	0	0	0	0	0	1	14395	1422	50	5		5	SIPA1L2	1	232600688	Silent	SNP	T	TCGA-CV-7407-01A-11D-2078-08	19419054	232600688	16649933	15	45301											
AKT3	10000	broad.mit.edu	37	chr1	243809217	243809217	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttttatgatgggttgtaGaggcatccatctcttcctct	6	18	8	9	0	3	2	0	1	3	1	6	2	5	2	2	2	0	3	2	2	2	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr1:243809217G>C	uc001iab.1	-	4	488	c.407C>G	c.(406-408)TCT>TGT	p.S136C	AKT3_uc001hzz.1_Missense_Mutation_p.S136C	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	136					signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			ATGGGTTGTAGAGGCATCCAT	0.383													8	61					0	0	0	0	C	243809217	C	C	243809217	3	2	247	1	0	0	0	0	1	0	0	0	481	942	33	2	1120	2	AKT3	1	243809217	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	11208529	243809217	5441404	16	45302											
PXDN	7837	broad.mit.edu	37	chr2	1653341	1653341	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcgtccggtacttctggtgGaagcacatgtccgagcagtt	7	11	13	10	3	1	0	0	0	1	0	3	2	3	1	2	3	4	4	2	3	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:1653341G>A	uc002qxa.2	-	17	2275	c.2211C>T	c.(2209-2211)TTC>TTT	p.F737F		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	737					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ACTTCTGGTGGAAGCACATGT	0.612													24	87					0	0	0	0	A	1653341	A	A	1653341	2	1	247	1	0	0	0	0	0	0	0	1	12912	1165	41	2		2	PXDN	2	1653341	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08		1653341	241546032	17	45303											
PXDN	7837	broad.mit.edu	37	chr2	1664729	1664729	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcatagcgacctgcgtcTgcagggccaacgtcattgat	9	9	10	13	3	3	1	2	1	1	0	3	2	3	1	2	1	4	1	2	1	2	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:1664729T>C	uc002qxa.2	-	14	1825	c.1761A>G	c.(1759-1761)GCA>GCG	p.A587A	PXDN_uc002qxb.1_Silent_p.A587A	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	587	Ig-like C2-type 4.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GACCTGCGTCTGCAGGGCCAA	0.522													10	32					0	0	0	0	C	1664729	C	C	1664729	2	2	247	1	0	0	0	0	0	0	0	1	12912	1567	55	5		5	PXDN	2	1664729	Silent	SNP	T	TCGA-CV-7407-01A-11D-2078-08	11388	1664729	241534644	18	45304											
APOB	338	broad.mit.edu	37	chr2	21231328	21231328	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgcttgaaaatcaaaattGagaacttctaatttggactc	14	15	6	6	0	2	2	1	2	1	1	3	4	2	3	0	1	2	1	0	1	6	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:21231328G>A	uc002red.2	-	26	8540	c.8412C>T	c.(8410-8412)CTC>CTT	p.L2804L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2804					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATCAAAATTGAGAACTTCTA	0.448													30	114					0	0	0	0	A	21231328	A	A	21231328	2	1	247	1	0	0	0	0	0	0	0	1	785	1277	45	2		2	APOB	2	21231328	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	19566599	21231328	221968045	19	45305											
CCDC121	79635	broad.mit.edu	37	chr2	27850176	27850176	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctttttctctttcccagtAgcctcctgtctggctcgctc	2	18	6	15	1	3	0	0	0	3	0	8	0	5	0	3	1	1	3	3	1	1	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:27850176A>G	uc002rle.2	-	2	672	c.491T>C	c.(490-492)CTA>CCA	p.L164P	ZNF512_uc010yly.1_Intron|CCDC121_uc010eze.2_Missense_Mutation_p.L328P|CCDC121_uc002rld.2_Missense_Mutation_p.L326P|GPN1_uc010ezf.2_5'Flank|GPN1_uc010yma.1_5'Flank|GPN1_uc010ymb.1_5'Flank|GPN1_uc010ymc.1_5'Flank|GPN1_uc010ymd.1_5'Flank|GPN1_uc010yme.1_5'Flank|GPN1_uc010ezg.1_5'Flank	NM_024584	NP_078860	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121 isoform 3	164	Potential.										0	Acute lymphoblastic leukemia(172;0.155)					CTTTCCCAGTAGCCTCCTGTC	0.483													24	84					0	0	0	0	G	27850176	G	G	27850176	3	3	247	1	0	0	0	0	1	0	0	0	2769	420	15	5	349	5	CCDC121	2	27850176	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	6618848	27850176	215349197	20	45306											
C2orf42	54980	broad.mit.edu	37	chr2	70408542	70408542	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcttctggcttgccttgcaTttcaccaccaagatgttttt	6	17	7	11	0	2	1	1	0	1	1	2	1	2	1	3	1	3	4	3	1	1	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:70408542T>C	uc002sgh.2	-	3	904	c.576A>G	c.(574-576)AAA>AAG	p.K192K		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	hypothetical protein LOC54980	192											0						TTGCCTTGCATTTCACCACCA	0.512													14	102					0	0	0	0	C	70408542	C	C	70408542	2	2	247	1	0	0	0	0	0	0	0	1	2176	1490	52	5		5	C2orf42	2	70408542	Silent	SNP	T	TCGA-CV-7407-01A-11D-2078-08	42558366	70408542	172790831	21	45307											
ZNF638	27332	broad.mit.edu	37	chr2	71653593	71653596	+	Frame_Shift_Del	DEL	CCAT	-	-																															ttttaactttccaacaggagCcattatttccatttaatttg																										TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:71653593_71653596delCCAT	uc002shx.2	+	24	4913_4916	c.4594_4597delCCAT	c.(4594-4599)CCATTAfs	p.P1532fs	ZNF638_uc002shy.2_Frame_Shift_Del_p.P1532fs|ZNF638_uc002shz.2_Frame_Shift_Del_p.P1532fs|ZNF638_uc002sia.2_Frame_Shift_Del_p.P1532fs|ZNF638_uc002sib.1_Frame_Shift_Del_p.S1123fs|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Frame_Shift_Del_p.P629fs|ZNF638_uc002sid.2_5'UTR	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1532_1533					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						CCAACAGGAGCCATTATTTCCATT	0.353													---	---	---								-	71653596	-	-	71653593	7	5	247	1	0	1	0	1	0	0	0	0	18122	739	26	0	4684	0	ZNF638	2	71653593	Frame_Shift_Del	DEL	CCAT	TCGA-CV-7407-01A-11D-2078-08	1245051	71653593	171545780	22	45308											
TSGA10	80705	broad.mit.edu	37	chr2	99720536	99720536	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagtgcttatggtttcctTcatcaaagtcatatttgaca	11	15	6	9	0	3	1	3	1	0	0	4	1	4	1	1	1	1	2	1	1	3	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:99720536T>C	uc002szg.3	-	8	1133	c.505A>G	c.(505-507)AAG>GAG	p.K169E	TSGA10_uc002szh.3_Missense_Mutation_p.K169E|TSGA10_uc002szi.3_Missense_Mutation_p.K169E|TSGA10_uc010fin.1_Missense_Mutation_p.K169E|TSGA10_uc010yvn.1_Missense_Mutation_p.K169E	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	169					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						ATGGTTTCCTTCATCAAAGTC	0.363													22	55					0	0	0	0	C	99720536	C	C	99720536	3	2	247	1	0	0	0	0	1	0	0	0	16684	1792	62	5	1639	5	TSGA10	2	99720536	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	28066943	99720536	143478837	23	45309											
IL18RAP	8807	broad.mit.edu	37	chr2	103068292	103068292	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatatttatcttgagccccaActatgtcaatggacccagta	13	12	6	10	0	2	1	1	1	1	0	2	2	2	2	3	1	2	1	3	1	7	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:103068292A>G	uc002tbx.2	+	12	1935	c.1451A>G	c.(1450-1452)AAC>AGC	p.N484S	IL18RAP_uc010fiz.2_Missense_Mutation_p.N342S	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	484	TIR.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						TTGAGCCCCAACTATGTCAAT	0.353													12	86					0	0	0	0	G	103068292	G	G	103068292	3	3	247	1	0	0	0	0	1	0	0	0	7687	43	2	5	1489	5	IL18RAP	2	103068292	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	3347756	103068292	140131081	24	45310											
CLASP1	23332	broad.mit.edu	37	chr2	122155929	122155929	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagtttgagtttgatccacaAtaaatctcatcaaaatgtta	15	14	6	6	0	2	2	2	2	1	0	4	3	3	2	1	0	0	3	1	0	6	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:122155929A>G	uc002tnc.2	-	28	3338	c.2948T>C	c.(2947-2949)ATT>ACT	p.I983T	CLASP1_uc010yyv.1_Missense_Mutation_p.I68T|CLASP1_uc002tmz.2_Missense_Mutation_p.I68T|CLASP1_uc002tna.2_Missense_Mutation_p.I68T|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.I963T|CLASP1_uc010yza.1_Missense_Mutation_p.I955T|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	983	HEAT 5.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					TTGATCCACAATAAATCTCAT	0.269													3	3					0	0	0	0	G	122155929	G	G	122155929	3	3	247	1	0	0	0	0	1	0	0	0	3469	101	4	5	1716	5	CLASP1	2	122155929	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	19087637	122155929	121043444	25	45311											
LCT	3938	broad.mit.edu	37	chr2	136566291	136566291	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctgcacgattctggagtagTacgtgttgaggcagaagacg	10	9	15	7	3	1	3	0	1	1	2	1	5	1	4	0	2	2	6	0	2	3	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:136566291T>G	uc002tuu.1	-	8	3637	c.3626A>C	c.(3625-3627)TAC>TCC	p.Y1209S		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1209	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCTGGAGTAGTACGTGTTGAG	0.577													45	96					0	0	0	0	G	136566291	G	G	136566291	3	3	247	1	0	0	0	0	1	0	0	0	8733	1638	57	5	2197	5	LCT	2	136566291	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	14410362	136566291	106633082	26	45312											
LRP1B	53353	broad.mit.edu	37	chr2	141533735	141533735	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcttattccgtaggatggtgGggtttcttccgtctcttttg	3	19	11	8	2	3	0	0	0	3	0	6	1	5	1	2	4	0	2	2	4	2	7			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:141533735G>T	uc002tvj.1	-	33	6404	c.5432C>A	c.(5431-5433)CCC>CAC	p.P1811H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1811	Extracellular (Potential).|LDL-receptor class B 18.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAGGATGGTGGGGTTTCTTCC	0.408										TSP Lung(27;0.18)			14	31					3.27435e-08	3.60385e-08	1	0	T	141533735	T	T	141533735	3	4	247	1	0	0	0	0	1	0	0	0	9005	1232	43	4	8603	4	LRP1B	2	141533735	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	4967444	141533735	101665638	27	45313											
FMNL2	114793	broad.mit.edu	37	chr2	153471451	153471451	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatgtaggagctctactggaAgatgctgaaactaagaatgc	14	9	12	6	0	1	3	0	1	1	2	1	6	1	5	0	2	5	3	0	2	6	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:153471451A>G	uc002tye.2	+	12	1516	c.1149A>G	c.(1147-1149)GAA>GAG	p.E383E		NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	383	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						CTCTACTGGAAGATGCTGAAA	0.398													13	40					0	0	0	0	G	153471451	G	G	153471451	2	3	247	1	0	0	0	0	0	0	0	1	5984	69	3	5		5	FMNL2	2	153471451	Silent	SNP	A	TCGA-CV-7407-01A-11D-2078-08	11937716	153471451	89727922	28	45314											
BAZ2B	29994	broad.mit.edu	37	chr2	160204060	160204060	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctacctgttgaaggacactCaaatccatttccattgcttg	10	14	6	11	0	2	1	1	1	1	0	4	2	4	2	3	1	2	2	3	1	3	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:160204060C>G	uc002uao.2	-	31	5743	c.5391G>C	c.(5389-5391)TTG>TTC	p.L1797F	BAZ2B_uc002uap.2_Missense_Mutation_p.L1761F	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1797					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						GAAGGACACTCAAATCCATTT	0.353													3	56					0	0	0	0	G	160204060	G	G	160204060	3	3	247	1	0	0	0	0	1	0	0	0	1334	825	29	2	1143	2	BAZ2B	2	160204060	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	6732609	160204060	82995313	29	45315											
COBLL1	22837	broad.mit.edu	37	chr2	165557131	165557131	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtcaggatcatttttcagtGtatttattatatcagtagat	12	18	7	4	0	4	1	4	0	0	1	4	2	4	2	0	1	0	2	0	1	5	8			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:165557131G>C	uc010zcw.1	-	13	1800	c.1676C>G	c.(1675-1677)ACA>AGA	p.T559R	COBLL1_uc002ucp.2_Missense_Mutation_p.T493R|COBLL1_uc002ucq.2_Missense_Mutation_p.T454R|COBLL1_uc010zcx.1_Missense_Mutation_p.T500R|COBLL1_uc002ucs.1_RNA|COBLL1_uc002ucn.2_5'Flank|COBLL1_uc002uco.2_Missense_Mutation_p.T223R	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	531										ovary(2)|pancreas(1)	3						ATTTTTCAGTGTATTTATTAT	0.373													12	87					0	0	0	0	C	165557131	C	C	165557131	3	2	247	1	0	0	0	0	1	0	0	0	3669	1377	48	4	2042	4	COBLL1	2	165557131	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	5353071	165557131	77642242	30	45316											
TTN	7273	broad.mit.edu	37	chr2	179433970	179433970	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtaattttttattttggatCccccatccaacaaaggaggt	11	15	7	8	0	0	0	0	0	0	0	2	2	2	2	3	3	1	1	3	3	4	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:179433970C>T	uc010zfg.1	-	275	69409	c.69185G>A	c.(69184-69186)GGA>GAA	p.G23062E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G16757E|TTN_uc010zfi.1_Missense_Mutation_p.G16690E|TTN_uc010zfj.1_Missense_Mutation_p.G16565E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23989							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTTTGGATCCCCCATCCAA	0.393													20	416					0	0	0	0	T	179433970	T	T	179433970	3	4	247	1	0	0	0	0	1	0	0	0	16803	855	30	2	31238	2	TTN	2	179433970	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	13876839	179433970	63765403	31	45317											
TTN	7273	broad.mit.edu	37	chr2	179457754	179457754	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtggctgccaagttagatCgactgaattgcatgttgtat	9	14	12	6	1	0	2	0	1	0	1	1	3	0	2	1	2	2	5	1	2	4	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:179457754C>T	uc010zfg.1	-	249	51612	c.51388G>A	c.(51388-51390)GAT>AAT	p.D17130N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D10825N|TTN_uc010zfi.1_Missense_Mutation_p.D10758N|TTN_uc010zfj.1_Missense_Mutation_p.D10633N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18057							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGTTAGATCGACTGAATTG	0.393													7	216					0	0	0	0	T	179457754	T	T	179457754	3	4	247	1	0	0	0	0	1	0	0	0	16803	884	31	1	49139	1	TTN	2	179457754	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	23784	179457754	63741619	32	45318											
TTN	7273	broad.mit.edu	37	chr2	179640277	179640277	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accattcacattcggggtctGgtttccccacgactctgacc	7	11	8	15	2	3	1	1	1	2	0	5	2	4	1	4	3	0	1	4	3	0	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:179640277G>A	uc010zfg.1	-	28	6538	c.6314C>T	c.(6313-6315)CCA>CTA	p.P2105L	TTN_uc010zfh.1_Missense_Mutation_p.P2059L|TTN_uc010zfi.1_Missense_Mutation_p.P2059L|TTN_uc010zfj.1_Missense_Mutation_p.P2059L|TTN_uc002unb.2_Missense_Mutation_p.P2105L|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2105							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCGGGGTCTGGTTTCCCCAC	0.478													5	96					0	0	0	0	A	179640277	A	A	179640277	3	1	247	1	0	0	0	0	1	0	0	0	16803	1348	47	4	105014	4	TTN	2	179640277	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	182523	179640277	63559096	33	45319											
DNAJC10	54431	broad.mit.edu	37	chr2	183616441	183616441	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagaaagtgtgaattctcatGttaccacgcttggacctcaa	13	11	8	9	1	2	2	2	1	1	1	3	3	2	3	2	1	1	2	2	1	5	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:183616441G>A	uc002uow.1	+	15	1778	c.1363G>A	c.(1363-1365)GTT>ATT	p.V455I	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Missense_Mutation_p.V409I|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	455	Thioredoxin 2.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GAATTCTCATGTTACCACGCT	0.353													20	276					0	0	0	0	A	183616441	A	A	183616441	3	1	247	1	0	0	0	0	1	0	0	0	4651	1377	48	4	1413	4	DNAJC10	2	183616441	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	3976164	183616441	59582932	34	45320											
NCKAP1	10787	broad.mit.edu	37	chr2	183845983	183845983	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtttttacctgcacgagttCattgaggacaacagcatcaa	13	11	8	9	1	2	1	2	1	0	0	2	3	2	2	1	1	4	4	1	1	3	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:183845983C>G	uc002upc.2	-	13	1732	c.1330G>C	c.(1330-1332)GAA>CAA	p.E444Q	NCKAP1_uc002upb.2_Missense_Mutation_p.E450Q	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	444					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGCACGAGTTCATTGAGGACA	0.383													5	110					0	0	0	0	G	183845983	G	G	183845983	3	3	247	1	0	0	0	0	1	0	0	0	10275	835	29	2	2132	2	NCKAP1	2	183845983	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	229542	183845983	59353390	35	45321											
NCKAP1	10787	broad.mit.edu	37	chr2	183866755	183866755	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaatcatctggccaaggcGtgggtattctctgtcactta	9	12	9	11	1	4	0	2	0	2	0	5	0	4	0	1	3	0	1	1	3	4	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:183866755G>C	uc002upc.2	-	6	931	c.529C>G	c.(529-531)CGC>GGC	p.R177G	NCKAP1_uc002upb.2_Missense_Mutation_p.R183G	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	177					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGGCCAAGGCGTGGGTATTCT	0.363													6	108					0	0	0	0	C	183866755	C	C	183866755	3	2	247	1	0	0	0	0	1	0	0	0	10275	1145	40	3	2961	3	NCKAP1	2	183866755	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	20772	183866755	59332618	36	45322											
ZNF142	7701	broad.mit.edu	37	chr2	219507041	219507041	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtctcctcatgctgttccaGgtagtgctttaccaggccca	7	12	9	13	0	2	0	1	0	1	0	4	0	3	0	4	2	3	4	4	2	2	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:219507041G>C	uc002vin.2	-	8	4634	c.4198C>G	c.(4198-4200)CTG>GTG	p.L1400V	ZNF142_uc002vil.2_Missense_Mutation_p.L1361V|ZNF142_uc010fvt.2_Missense_Mutation_p.L1237V|ZNF142_uc002vim.2_Missense_Mutation_p.L1237V	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1400	C2H2-type 23.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TGCTGTTCCAGGTAGTGCTTT	0.612													17	43					0	0	0	0	C	219507041	C	C	219507041	3	2	247	1	0	0	0	0	1	0	0	0	17798	991	35	4	877	4	ZNF142	2	219507041	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	35640286	219507041	23692332	37	45323											
SLC4A3	6508	broad.mit.edu	37	chr2	220494312	220494312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgtctgcagttctccattgGaagtgacgaggatgacagtc	10	11	12	8	1	2	2	0	2	2	0	4	5	2	4	1	2	1	2	1	2	1	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:220494312G>A	uc002vmp.3	+	5	775	c.506G>A	c.(505-507)GGA>GAA	p.G169E	SLC4A3_uc002vmn.2_Missense_Mutation_p.G169E|SLC4A3_uc002vmo.3_Missense_Mutation_p.G169E|SLC4A3_uc010fwm.2_5'UTR|SLC4A3_uc010fwn.1_5'Flank	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	169	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTCTCCATTGGAAGTGACGAG	0.637													13	22					0	0	0	0	A	220494312	A	A	220494312	3	1	247	1	0	0	0	0	1	0	0	0	14719	1174	41	2	520	2	SLC4A3	2	220494312	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	987271	220494312	22705061	38	45324											
FARP2	9855	broad.mit.edu	37	chr2	242401976	242401976	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctacttcatagtcaaagaGattctcgctacagaacgaac	14	9	7	11	2	3	2	2	0	1	2	4	4	3	2	1	0	4	1	1	0	6	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr2:242401976G>A	uc002wbi.1	+	15	1743	c.1626G>A	c.(1624-1626)GAG>GAA	p.E542E	FARP2_uc010zoq.1_Silent_p.E542E|FARP2_uc010zor.1_Silent_p.E542E	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	542	DH.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		TAGTCAAAGAGATTCTCGCTA	0.453													9	50					0	0	0	0	A	242401976	A	A	242401976	2	1	247	1	0	0	0	0	0	0	0	1	5709	933	33	2		2	FARP2	2	242401976	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	21907664	242401976	797397	39	45325											
NICN1	84276	broad.mit.edu	37	chr3	49462293	49462293	+	Frame_Shift_Del	DEL	A	-	-																															taggagagcaagttcaggtcAtaacagccatccacctgaaa																										TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr3:49462293delA	uc003cwz.1	-	6	700	c.615delT	c.(613-615)TATfs	p.Y205fs	AMT_uc011bcn.1_5'Flank|AMT_uc003cww.2_5'Flank|AMT_uc003cwx.2_5'Flank|AMT_uc011bco.1_5'Flank|AMT_uc003cwy.2_5'Flank|AMT_uc011bcp.1_5'Flank|AMT_uc011bcq.1_5'Flank|NICN1_uc003cxa.2_RNA|NICN1_uc011bcr.1_Frame_Shift_Del_p.Y167fs	NM_032316	NP_115692	Q9BSH3	NICN1_HUMAN	nicolin 1	205						microtubule|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;4.52e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGTTCAGGTCATAACAGCCAT	0.507													---	---	---								-	49462293	-	-	49462293	7	5	247	1	0	1	0	1	0	0	0	0	10467	224	8	0	30	0	NICN1	3	49462293	Frame_Shift_Del	DEL	A	TCGA-CV-7407-01A-11D-2078-08		49462293	148560137	40	45326											
ZIC1	7545	broad.mit.edu	37	chr3	147128517	147128517	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgaacgtgaacatggccgcGcatcacggcgccggcgcctt	8	6	13	14	7	1	2	1	2	0	0	1	2	1	2	3	3	2	1	3	3	2	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr3:147128517G>A	uc003ewe.2	+	1	1337	c.618G>A	c.(616-618)GCG>GCA	p.A206A		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	206					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ACATGGCCGCGCATCACGGCG	0.652													14	48					0	0	0	0	A	147128517	A	A	147128517	2	1	247	1	0	0	0	0	0	0	0	1	17745	1074	38	1		1	ZIC1	3	147128517	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	97666224	147128517	50893913	41	45327											
SI	6476	broad.mit.edu	37	chr3	164741544	164741544	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggaaagtaacactcaggTgctttggatagagaagaacc	14	8	12	7	0	1	2	1	0	0	2	1	5	1	4	1	3	3	2	1	3	5	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr3:164741544T>A	uc003fei.2	-	26	2975	c.2913A>T	c.(2911-2913)GCA>GCT	p.A971A		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	971	Lumenal.|P-type 2.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AACACTCAGGTGCTTTGGATA	0.363										HNSCC(35;0.089)			18	90					0	0	0	0	A	164741544	A	A	164741544	2	1	247	1	0	0	0	0	0	0	0	1	14362	1683	59	5		5	SI	3	164741544	Silent	SNP	T	TCGA-CV-7407-01A-11D-2078-08	17613027	164741544	33280886	42	45328											
KIAA0226	9711	broad.mit.edu	37	chr3	197423824	197423845	+	Splice_Site	DEL	CCATATTCCATGTACAGAGAGC	-	-																															cctggccttcctagtactcaCcatattccatgtacagagag																										TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr3:197423824_197423845delCCATATTCCATGTACAGAGAGC	uc003fyc.2	-	8	1540	c.1357_splice	c.e8+1	p.E453_splice	KIAA0226_uc003fyd.3_Splice_Site_p.E408_splice|KIAA0226_uc003fye.1_Splice_Site_p.E160_splice|KIAA0226_uc003fyf.2_Splice_Site_p.E301_splice	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.						autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		CTAGTACTCACCATATTCCATGTACAGAGAGCTGGGTGTGCT	0.486													---	---	---								-	197423845	-	-	197423824	8	5	247	1	0	1	0	1	0	0	1	0	8201	521	18	0	1612	0	KIAA0226	3	197423824	Splice_Site	DEL	CCATATTCCATGTACAGAGAGC	TCGA-CV-7407-01A-11D-2078-08	32682280	197423824	598606	43	45329											
EVC	2121	broad.mit.edu	37	chr4	5755517	5755517	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttcaatcccagagtttGtccagcgaggcaaagacctg	10	12	9	10	1	1	2	1	0	0	2	3	3	3	2	3	1	1	2	3	1	2	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr4:5755517G>A	uc003gil.1	+	10	1505	c.1321G>A	c.(1321-1323)GTC>ATC	p.V441I	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	441					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				CCCAGAGTTTGTCCAGCGAGG	0.552													5	91					0	0	0	0	A	5755517	A	A	5755517	3	1	247	1	0	0	0	0	1	0	0	0	5309	1377	48	4	1359	4	EVC	4	5755517	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08		5755517	185398759	44	45330											
ZNF518B	85460	broad.mit.edu	37	chr4	10444982	10444982	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcattctggtaggtcaggcGtacatgatgccgtctgatgc	7	11	13	10	3	3	2	1	2	2	0	3	2	3	2	1	3	3	3	1	3	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr4:10444982G>A	uc003gmn.2	-	3	3458	c.2971C>T	c.(2971-2973)CGC>TGC	p.R991C		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	991					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						TAGGTCAGGCGTACATGATGC	0.383													16	51					0	0	0	0	A	10444982	A	A	10444982	3	1	247	1	0	0	0	0	1	0	0	0	18030	1145	40	1	257	1	ZNF518B	4	10444982	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	4689465	10444982	180709294	45	45331											
IRF2	3660	broad.mit.edu	37	chr4	185340660	185340660	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttctaaagagtggtgcatcTttttccacatcccacccatg	9	14	6	12	0	2	1	0	0	2	1	4	1	4	1	3	1	1	1	3	1	2	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr4:185340660T>C	uc003iwf.3	-	3	350	c.150A>G	c.(148-150)AAA>AAG	p.K50K		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	50	IRF tryptophan pentad repeat.				blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		GTGGTGCATCTTTTTCCACAT	0.398													11	82					0	0	0	0	C	185340660	C	C	185340660	2	2	247	1	0	0	0	0	0	0	0	1	7867	1606	56	5		5	IRF2	4	185340660	Silent	SNP	T	TCGA-CV-7407-01A-11D-2078-08	174895678	185340660	5813616	46	45332											
ADCY2	108	broad.mit.edu	37	chr5	7695903	7695903	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttggctttacccggctggCaagtgactgctccccgggag	5	9	14	13	3	0	1	0	1	0	0	1	2	1	2	3	4	2	5	3	4	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:7695903C>A	uc003jdz.1	+	6	975	c.908C>A	c.(907-909)GCA>GAA	p.A303E	ADCY2_uc011cmo.1_Missense_Mutation_p.A123E	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	303	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						ACCCGGCTGGCAAGTGACTGC	0.428													15	14					2.32078e-09	2.60344e-09	1	0	A	7695903	A	A	7695903	3	1	247	1	0	0	0	0	1	0	0	0	294	710	25	4	930	4	ADCY2	5	7695903	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08		7695903	173219357	47	45333											
SEMA5A	9037	broad.mit.edu	37	chr5	9224908	9224908	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcatagagctccccaccaGctgtgaggagcgctgtggaa	10	6	13	12	1	0	2	0	1	0	1	1	4	1	4	3	2	4	4	3	2	2	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:9224908G>C	uc003jek.2	-	8	1236	c.524C>G	c.(523-525)GCT>GGT	p.A175G		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	175	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CTCCCCACCAGCTGTGAGGAG	0.572													15	19					0	0	0	0	C	9224908	C	C	9224908	3	2	247	1	0	0	0	0	1	0	0	0	14102	971	34	4	2764	4	SEMA5A	5	9224908	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	1529005	9224908	171690352	48	45334											
RICTOR	253260	broad.mit.edu	37	chr5	38950400	38950400	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accaaaattcttggtgaattTtaagtcattttctccaatgc	12	16	5	8	0	3	1	1	1	2	0	4	1	3	1	2	1	1	0	2	1	5	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:38950400T>G	uc003jlp.2	-	31	3574	c.3550A>C	c.(3550-3552)AAA>CAA	p.K1184Q	RICTOR_uc003jlo.2_Missense_Mutation_p.K1184Q|RICTOR_uc010ivf.2_Missense_Mutation_p.K899Q	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1184					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TTGGTGAATTTTAAGTCATTT	0.368													29	137					0	0	0	0	G	38950400	G	G	38950400	3	3	247	1	0	0	0	0	1	0	0	0	13423	1850	64	5	1608	5	RICTOR	5	38950400	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	29725492	38950400	141964860	49	45335											
CCNB1	891	broad.mit.edu	37	chr5	68467126	68467126	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcctctccaagcccaatggaAacatctggatgtgcccctgc	9	8	9	15	0	2	0	0	0	2	0	3	2	2	2	5	2	4	0	5	2	3	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:68467126A>C	uc003jvm.2	+	4	570	c.393A>C	c.(391-393)GAA>GAC	p.E131D	CCNB1_uc011crd.1_Missense_Mutation_p.E131D|CCNB1_uc010ixb.2_Missense_Mutation_p.E131D	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	131					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		GCCCAATGGAAACATCTGGAT	0.423													3	46					0	0	0	0	C	68467126	C	C	68467126	3	2	247	1	0	0	0	0	1	0	0	0	2926	11	1	5	407	5	CCNB1	5	68467126	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	29516726	68467126	112448134	50	45336											
FER	2241	broad.mit.edu	37	chr5	108233448	108233448	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcactgaagcaaagttttcaGcacagaaggaattactagag	16	8	10	7	0	1	3	1	1	0	2	1	4	1	4	0	1	3	4	0	1	6	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:108233448G>C	uc003kop.1	+	10	1519	c.1135G>C	c.(1135-1137)GCA>CCA	p.A379P	FER_uc011cvf.1_Intron|FER_uc011cvg.1_Missense_Mutation_p.A204P	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	379	Potential.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		AAAGTTTTCAGCACAGAAGGA	0.398													4	23					0	0	0	0	C	108233448	C	C	108233448	3	2	247	1	0	0	0	0	1	0	0	0	5845	971	34	4	1165	4	FER	5	108233448	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	39766322	108233448	72681812	51	45337											
PCDHA1	56147	broad.mit.edu	37	chr5	140167440	140167440	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caaggtgtacgcactgcagcCcctggaccacgaggagctgg	9	5	14	13	2	0	0	0	0	0	0	0	3	0	2	3	4	4	4	3	4	2	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:140167440C>T	uc003lhb.2	+	1	1565	c.1565C>T	c.(1564-1566)CCC>CTC	p.P522L	PCDHA1_uc003lha.2_Missense_Mutation_p.P522L|PCDHA1_uc003lgz.2_Missense_Mutation_p.P522L	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	522	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACTGCAGCCCCTGGACCAC	0.677													39	35					0	0	0	0	T	140167440	T	T	140167440	3	4	247	1	0	0	0	0	1	0	0	0	11573	623	22	4	1567	4	PCDHA1	5	140167440	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	31933992	140167440	40747820	52	45338											
DOCK2	1794	broad.mit.edu	37	chr5	169508940	169508940	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaactctcagatggtgaCaagaagacactcacacggaa	15	6	8	12	1	2	4	2	1	1	3	4	5	3	5	1	2	1	0	1	2	4	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:169508940C>A	uc003maf.2	+	51	5462	c.5382C>A	c.(5380-5382)GAC>GAA	p.D1794E	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.D1286E|DOCK2_uc003mah.2_Missense_Mutation_p.D350E	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1794					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGATGGTGACAAGAAGACAC	0.542													5	38					0.000602214	0.000634865	1	0	A	169508940	A	A	169508940	3	1	247	1	0	0	0	0	1	0	0	0	4709	477	17	4	5584	4	DOCK2	5	169508940	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	29341500	169508940	11406320	53	45339											
RANBP17	64901	broad.mit.edu	37	chr5	170668104	170668104	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgacaatgtactccaggcTtttgtcaaaatgctgctgtc	9	15	8	9	0	1	1	1	1	0	0	3	1	2	1	1	1	3	4	1	1	4	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:170668104T>G	uc003mba.2	+	23	2611	c.2595T>G	c.(2593-2595)GCT>GCG	p.A865A	RANBP17_uc003mbb.2_Silent_p.A190A|RANBP17_uc003mbd.2_Silent_p.A228A|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	865					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TACTCCAGGCTTTTGTCAAAA	0.438			T	TRD@	ALL								32	96					0	0	0	0	G	170668104	G	G	170668104	2	3	247	1	0	0	0	0	0	0	0	1	13092	1596	56	5		5	RANBP17	5	170668104	Silent	SNP	T	TCGA-CV-7407-01A-11D-2078-08	1159164	170668104	10247156	54	45340											
DDX41	51428	broad.mit.edu	37	chr5	176939861	176939861	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtccacgtctgccttcttcTctgcaaagatgagtacctgt	7	13	8	13	2	3	2	0	1	3	1	5	2	4	2	3	0	3	2	3	0	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr5:176939861T>C	uc003mho.2	-	13	1340	c.1319A>G	c.(1318-1320)GAG>GGG	p.E440G	DOK3_uc003mhi.3_5'Flank|DOK3_uc003mhj.3_5'Flank|DOK3_uc003mhl.2_5'Flank|DDX41_uc003mhm.2_Missense_Mutation_p.E220G|DDX41_uc003mhn.2_Missense_Mutation_p.E309G|DDX41_uc003mhp.2_Missense_Mutation_p.E309G|DDX41_uc003mhq.1_Missense_Mutation_p.E220G	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	440	Helicase C-terminal.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			TGCCTTCTTCTCTGCAAAGAT	0.607													11	68					0	0	0	0	C	176939861	C	C	176939861	3	2	247	1	0	0	0	0	1	0	0	0	4378	1551	54	5	569	5	DDX41	5	176939861	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	6271757	176939861	3975399	55	45341											
HIST1H1T	3010	broad.mit.edu	37	chr6	26107762	26107762	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtcaattttgacttcgaaGcccttgccttcactgggctc	6	13	10	12	1	2	1	2	1	0	0	4	2	2	1	2	2	2	1	2	2	2	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:26107762G>A	uc003ngj.2	-	1	603	c.560C>T	c.(559-561)GCT>GTT	p.A187V		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	187					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						TGACTTCGAAGCCCTTGCCTT	0.468													20	99					0	0	0	0	A	26107762	A	A	26107762	3	1	247	1	0	0	0	0	1	0	0	0	7166	971	34	4	67	4	HIST1H1T	6	26107762	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08		26107762	145007305	56	45342											
HIST1H2AL	8332	broad.mit.edu	37	chr6	27833180	27833180	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagctcgcgccaaagccaaGacccgctcttctcgtgccgg	9	6	10	16	5	2	1	0	0	2	1	4	1	2	1	4	1	3	2	4	1	3	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:27833180G>A	uc003njw.2	+	1	74	c.48G>A	c.(46-48)AAG>AAA	p.K16K		NM_003511	NP_003502	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	16					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						CCAAAGCCAAGACCCGCTCTT	0.637													13	101					0	0	0	0	A	27833180	A	A	27833180	2	1	247	1	0	0	0	0	0	0	0	1	7177	933	33	2		2	HIST1H2AL	6	27833180	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	1725418	27833180	143281887	57	45343											
PGBD1	84547	broad.mit.edu	37	chr6	28268549	28268549	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actcctattgctactgaaagGacagttgcacatttgaacac	13	11	7	10	0	0	2	0	2	0	0	1	3	1	3	1	1	4	3	1	1	4	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:28268549G>A	uc003nky.2	+	7	1288	c.918G>A	c.(916-918)AGG>AGA	p.R306R	PGBD1_uc003nkz.2_Silent_p.R306R	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	306					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						CTACTGAAAGGACAGTTGCAC	0.448													4	53					0	0	0	0	A	28268549	A	A	28268549	2	1	247	1	0	0	0	0	0	0	0	1	11835	1165	41	2		2	PGBD1	6	28268549	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	435369	28268549	142846518	58	45344											
OR12D3	81797	broad.mit.edu	37	chr6	29342160	29342160	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaacttcctaccaaagattTtcttcagagccatcatcact	13	12	3	13	0	4	2	3	0	1	2	5	2	5	2	3	0	3	0	3	0	3	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:29342160T>G	uc003nme.2	-	1	909	c.905A>C	c.(904-906)AAA>ACA	p.K302T		NM_030959	NP_112221	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3						ACCAAAGATTTTCTTCAGAGC	0.428													4	132					0	0	0	0	G	29342160	G	G	29342160	3	3	247	1	0	0	0	0	1	0	0	0	10986	1841	64	5	49	5	OR12D3	6	29342160	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	1073611	29342160	141772907	59	45345											
COL11A2	1302	broad.mit.edu	37	chr6	33156845	33156845	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	catacaggaagcggacaggtCggcccagctccaggcccagc	10	3	13	15	2	0	0	0	0	0	0	2	2	1	2	3	5	4	1	3	5	2	1	rs41268014		TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:33156845C>G	uc003ocx.1	-	3	581	c.353G>C	c.(352-354)CGA>CCA	p.R118P	COL11A2_uc003ocy.1_Missense_Mutation_p.R118P|COL11A2_uc003ocz.1_Missense_Mutation_p.R118P|COL11A2_uc003oda.2_Missense_Mutation_p.R118P	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	118	TSP N-terminal.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GCGGACAGGTCGGCCCAGCTC	0.617													4	84					0	0	0	0	G	33156845	G	G	33156845	3	3	247	1	0	0	0	0	1	0	0	0	3683	884	31	3	5188	3	COL11A2	6	33156845	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	3814685	33156845	137958222	60	45346											
SLC26A8	116369	broad.mit.edu	37	chr6	35919038	35919038	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgacaaggcaaacagcaCggcgtcgtgaacgctgagga	12	5	13	11	4	0	3	0	3	0	0	1	4	0	4	1	3	3	3	1	3	3	1	rs115071158	by1000genomes	TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:35919038C>T	uc003olm.2	-	19	2485	c.2374G>A	c.(2374-2376)GTG>ATG	p.V792M	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.V374M|SLC26A8_uc003oln.2_Missense_Mutation_p.V792M|SLC26A8_uc003oll.2_Missense_Mutation_p.V687M	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	792	Interaction with RACGAP1.|STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						GCAAACAGCACGGCGTCGTGA	0.488													12	50					0	0	0	0	T	35919038	T	T	35919038	3	4	247	1	0	0	0	0	1	0	0	0	14587	536	19	1	546	1	SLC26A8	6	35919038	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	2762193	35919038	135196029	61	45347											
TCTE1	202500	broad.mit.edu	37	chr6	44253954	44253954	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggccgggagctgcaccggcGgaaggaactgatcgacgtgg	8	4	19	10	5	0	1	0	1	0	0	1	5	0	4	2	6	3	2	2	6	2	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:44253954G>A	uc003oxi.2	-	3	749	c.593C>T	c.(592-594)CCG>CTG	p.P198L	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	198										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTGCACCGGCGGAAGGAACTG	0.657													6	33					0	0	0	0	A	44253954	A	A	44253954	3	1	247	1	0	0	0	0	1	0	0	0	15783	1116	39	1	924	1	TCTE1	6	44253954	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	8334916	44253954	126861113	62	45348											
MDN1	23195	broad.mit.edu	37	chr6	90482425	90482425	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggacggccgtgtagcagcGaaagtgaacttctccctggg	9	7	15	10	3	1	1	0	1	1	0	2	4	1	2	2	3	3	2	2	3	3	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:90482425G>A	uc003pnn.1	-	14	2066	c.1950C>T	c.(1948-1950)TTC>TTT	p.F650F	MDN1_uc003pno.1_Silent_p.F68F	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	650					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTGTAGCAGCGAAAGTGAACT	0.498													10	51					0	0	0	0	A	90482425	A	A	90482425	2	1	247	1	0	0	0	0	0	0	0	1	9468	1049	37	1		1	MDN1	6	90482425	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	46228471	90482425	80632642	63	45349											
GPR63	81491	broad.mit.edu	37	chr6	97246956	97246956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggaaggtatctgcaggtcggGgtttcctacggctaaaggaa	10	9	15	7	2	1	0	0	0	1	0	3	2	2	2	1	7	2	4	1	7	6	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:97246956G>A	uc010kcl.2	-	3	1130	c.652C>T	c.(652-654)CCC>TCC	p.P218S	GPR63_uc003pou.2_Missense_Mutation_p.P218S	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	218	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		TGCAGGTCGGGGTTTCCTACG	0.463													11	52					0	0	0	0	A	97246956	A	A	97246956	3	1	247	1	0	0	0	0	1	0	0	0	6742	1232	43	4	611	4	GPR63	6	97246956	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	6764531	97246956	73868111	64	45350											
SYNE1	23345	broad.mit.edu	37	chr6	152651117	152651117	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgagctctgccttcactctCctcagccagtccagggagcg	6	9	10	16	1	4	1	2	1	2	0	6	2	5	2	4	1	4	1	4	1	0	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr6:152651117C>T	uc010kiw.2	-	78	15305	c.14703G>A	c.(14701-14703)AGG>AGA	p.R4901R	SYNE1_uc003qot.3_Silent_p.R4830R|SYNE1_uc003qou.3_Silent_p.R4901R|SYNE1_uc010kiz.2_Silent_p.R656R	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4901	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTTCACTCTCCTCAGCCAGT	0.517										HNSCC(10;0.0054)			23	59					0	0	0	0	T	152651117	T	T	152651117	2	4	247	1	0	0	0	0	0	0	0	1	15511	854	30	2		2	SYNE1	6	152651117	Silent	SNP	C	TCGA-CV-7407-01A-11D-2078-08	55404161	152651117	18463950	65	45351											
ZNF716	441234	broad.mit.edu	37	chr7	57528634	57528634	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcagctacccaaaacaaaaCatttcagactcataaatgcg	17	8	5	11	1	3	1	3	0	0	1	3	1	3	1	1	0	5	1	1	0	7	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:57528634C>T	uc011kdi.1	+	4	579	c.467C>T	c.(466-468)ACA>ATA	p.T156I		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						CAAAACAAAACATTTCAGACT	0.323													6	10					0	0	0	0	T	57528634	T	T	57528634	3	4	247	1	0	0	0	0	1	0	0	0	18186	478	17	4	481	4	ZNF716	7	57528634	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08		57528634	101610029	66	45352											
ZNF804B	219578	broad.mit.edu	37	chr7	88963965	88963965	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaatataatttggactacAgtgattctgagccaaataag	16	11	9	5	0	1	2	0	2	1	0	1	4	1	4	1	2	2	0	1	2	6	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:88963965A>C	uc011khi.1	+	4	2207	c.1669A>C	c.(1669-1671)AGT>CGT	p.S557R		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	557						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TTTGGACTACAGTGATTCTGA	0.343										HNSCC(36;0.09)			7	48					0	0	0	0	C	88963965	C	C	88963965	3	2	247	1	0	0	0	0	1	0	0	0	18238	188	7	5	1683	5	ZNF804B	7	88963965	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	31435331	88963965	70174698	67	45353											
TRRAP	8295	broad.mit.edu	37	chr7	98580905	98580905	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggcagcccagcaaatcatcGaactccaggaagctgcacaa	15	4	9	13	1	1	0	1	0	0	0	3	2	2	1	2	2	5	4	2	2	4	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:98580905G>A	uc003upp.2	+	59	9033	c.8824G>A	c.(8824-8826)GAA>AAA	p.E2942K	TRRAP_uc011kis.1_Missense_Mutation_p.E2924K|TRRAP_uc003upr.2_Missense_Mutation_p.E2641K	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2942	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GCAAATCATCGAACTCCAGGA	0.517													6	19					0	0	0	0	A	98580905	A	A	98580905	3	1	247	1	0	0	0	0	1	0	0	0	16668	1059	37	1	8996	1	TRRAP	7	98580905	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	9616940	98580905	60557758	68	45354											
CUX1	1523	broad.mit.edu	37	chr7	101559503	101559503	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcaagaagaacactccaGaggtgaggcgcgtgaccatc	13	6	12	10	2	1	5	1	2	0	3	3	5	2	5	2	2	1	1	2	2	3	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:101559503G>T	uc003uyx.3	+	2	177	c.139G>T	c.(139-141)GAG>TAG	p.E47*	CUX1_uc003uys.3_Nonsense_Mutation_p.E58*|CUX1_uc003uyt.2_Nonsense_Mutation_p.E58*|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Nonsense_Mutation_p.E58*|CUX1_uc003uyv.2_Nonsense_Mutation_p.E58*|CUX1_uc003uyu.2_Nonsense_Mutation_p.E58*	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	47	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GAACACTCCAGAGGTGAGGCG	0.532													7	55					0.00198382	0.00206648	1	0	T	101559503	T	T	101559503	4	4	247	1	0	0	0	0	0	1	0	0	4081	943	33	2	212	2	CUX1	7	101559503	Nonsense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	2978598	101559503	57579160	69	45355											
FBXL13	222235	broad.mit.edu	37	chr7	102523890	102523890	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcttgtctataaatttgaagGatgcatcagtaaccctttta	12	16	6	7	0	3	1	1	1	2	0	3	2	3	2	1	1	2	2	1	1	6	7			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:102523890G>C	uc003vaq.2	-	14	1677	c.1250C>G	c.(1249-1251)TCC>TGC	p.S417C	FBXL13_uc010liq.1_Intron|FBXL13_uc010lir.1_Missense_Mutation_p.S417C|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.S417C	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	417	LRR 8.										0						AAATTTGAAGGATGCATCAGT	0.343													14	37					0	0	0	0	C	102523890	C	C	102523890	3	2	247	1	0	0	0	0	1	0	0	0	5741	1174	41	2	985	2	FBXL13	7	102523890	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	964387	102523890	56614773	70	45356											
RELN	5649	broad.mit.edu	37	chr7	103138354	103138354	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgttctcactaccgatgcGcccccagtattgcaggaacc	8	10	9	14	2	1	0	1	0	1	0	2	2	1	1	4	1	4	4	4	1	3	5	rs114501042	by1000genomes	TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:103138354G>A	uc003vca.2	-	55	9023	c.8863C>T	c.(8863-8865)CGC>TGC	p.R2955C	RELN_uc010liz.2_Missense_Mutation_p.R2955C	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2955					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTACCGATGCGCCCCCAGTAT	0.468													11	37					0	0	0	0	A	103138354	A	A	103138354	3	1	247	1	0	0	0	0	1	0	0	0	13285	1087	38	1	1563	1	RELN	7	103138354	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	614464	103138354	56000309	71	45357											
TFEC	22797	broad.mit.edu	37	chr7	115580975	115580975	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaccatgagtacgagcctgaAtttctagttcctgtaatttc	10	14	8	9	1	1	2	0	2	1	0	3	4	2	2	3	0	2	3	3	0	4	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:115580975A>C	uc003vhj.1	-	8	858	c.674T>G	c.(673-675)ATT>AGT	p.I225S	TFEC_uc003vhk.1_Missense_Mutation_p.I196S|TFEC_uc003vhl.3_3'UTR|TFEC_uc011kmw.1_3'UTR	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	225						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			ACGAGCCTGAATTTCTAGTTC	0.388													9	61					0	0	0	0	C	115580975	C	C	115580975	3	2	247	1	0	0	0	0	1	0	0	0	15868	101	4	5	373	5	TFEC	7	115580975	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	12442621	115580975	43557688	72	45358											
FEZF1	389549	broad.mit.edu	37	chr7	121943895	121943895	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accaccagtttattcctttcGgctaaatacgtttttggctg	8	16	7	10	2	0	0	0	0	0	0	2	0	1	0	3	2	1	4	3	2	4	8			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:121943895G>A	uc003vkd.2	-	1	671	c.597C>T	c.(595-597)GCC>GCT	p.A199A	FEZF1_uc003vkc.2_Silent_p.A149A|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	199					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						TATTCCTTTCGGCTAAATACG	0.557													4	42					0	0	0	0	A	121943895	A	A	121943895	2	1	247	1	0	0	0	0	0	0	0	1	5857	1103	39	1		1	FEZF1	7	121943895	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	6362920	121943895	37194768	73	45359											
GRM8	2918	broad.mit.edu	37	chr7	126882949	126882949	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggtgtccctagagcacgtgtCgaggatgcggacacccagag	9	6	15	11	3	0	2	0	0	0	2	2	5	1	4	2	3	2	1	2	3	1	1	rs147289844		TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:126882949C>G	uc003vlr.2	-	1	621	c.310G>C	c.(310-312)GAC>CAC	p.D104H	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.D104H|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	104	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GAGCACGTGTCGAGGATGCGG	0.478										HNSCC(24;0.065)			11	39					0	0	0	0	G	126882949	G	G	126882949	3	3	247	1	0	0	0	0	1	0	0	0	6842	884	31	3	2506	3	GRM8	7	126882949	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	4939054	126882949	32255714	74	45360											
GRM8	2918	broad.mit.edu	37	chr7	126883115	126883115	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacagggaagagacccccCaaaataatgtccccatccac	14	5	8	14	0	0	1	0	0	0	1	2	4	2	3	6	2	0	0	6	2	4	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr7:126883115C>T	uc003vlr.2	-	1	455	c.144G>A	c.(142-144)TTG>TTA	p.L48L	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.L48L|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	48	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AGAGACCCCCCAAAATAATGT	0.527										HNSCC(24;0.065)			13	84					0	0	0	0	T	126883115	T	T	126883115	2	4	247	1	0	0	0	0	0	0	0	1	6842	593	21	4		4	GRM8	7	126883115	Silent	SNP	C	TCGA-CV-7407-01A-11D-2078-08	166	126883115	32255548	75	45361											
ERICH1	157697	broad.mit.edu	37	chr8	614671	614671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagctgagattactctggCatggtctagaaagcaaaaaa	17	8	10	6	0	2	2	0	1	2	2	2	4	2	2	0	2	3	3	0	2	7	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr8:614671C>T	uc003wph.2	-	6	1329	c.1264G>A	c.(1264-1266)GCC>ACC	p.A422T	ERICH1_uc011kwh.1_Intron|ERICH1_uc003wpe.1_Intron	NM_207332	NP_997215	Q86X53	ERIC1_HUMAN	glutamate-rich 1	422										large_intestine(2)	2		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		ATTACTCTGGCATGGTCTAGA	0.313													4	43					0	0	0	0	T	614671	T	T	614671	3	4	247	1	0	0	0	0	1	0	0	0	5254	710	25	4	71	4	ERICH1	8	614671	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08		614671	145749351	76	45362											
TRIM35	23087	broad.mit.edu	37	chr8	27146779	27146779	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgggctggactggctctggCtccatggtgcagaagagtct	6	9	15	11	1	2	2	0	0	2	2	3	3	3	3	2	5	1	4	2	5	1	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr8:27146779C>A	uc003xfl.1	-	5	886	c.804G>T	c.(802-804)GAG>GAT	p.E268D	TRIM35_uc010lup.1_Missense_Mutation_p.A229S	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	268					apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		CTGGCTCTGGCTCCATGGTGC	0.567													3	15					0.004672	0.00480941	1	0	A	27146779	A	A	27146779	3	1	247	1	0	0	0	0	1	0	0	0	16576	796	28	4	685	4	TRIM35	8	27146779	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	26532108	27146779	119217243	77	45363											
EYA1	2138	broad.mit.edu	37	chr8	72211931	72211931	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aattatttcctgtatatattCctgatgatgttgtaaaactg	12	18	6	5	0	0	2	0	2	0	0	2	2	2	2	2	0	1	3	2	0	7	8			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr8:72211931C>T	uc003xys.3	-	7	868	c.581G>A	c.(580-582)GGA>GAA	p.G194E	EYA1_uc003xyr.3_Missense_Mutation_p.G189E|EYA1_uc003xyt.3_Missense_Mutation_p.G161E|EYA1_uc010lzf.2_Missense_Mutation_p.G121E|EYA1_uc003xyu.2_Missense_Mutation_p.G194E|EYA1_uc011lfe.1_Missense_Mutation_p.G188E|EYA1_uc003xyv.2_Missense_Mutation_p.G72E	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	194					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TGTATATATTCCTGATGATGT	0.303													37	55					0	0	0	0	T	72211931	T	T	72211931	3	4	247	1	0	0	0	0	1	0	0	0	5353	855	30	2	1241	2	EYA1	8	72211931	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	45065152	72211931	74152091	78	45364											
ZFHX4	79776	broad.mit.edu	37	chr8	77764068	77764068	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgtggctggtgggcacagCattgcagcaaatgtcaacag	11	8	13	9	0	1	0	1	0	0	0	1	0	1	0	0	3	4	5	0	3	2	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr8:77764068C>T	uc003yav.2	+	10	5163	c.4776C>T	c.(4774-4776)AGC>AGT	p.S1592S	ZFHX4_uc003yau.1_Silent_p.S1637S|ZFHX4_uc003yaw.1_Silent_p.S1592S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1592						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTGGGCACAGCATTGCAGCAA	0.488										HNSCC(33;0.089)			4	45					0	0	0	0	T	77764068	T	T	77764068	2	4	247	1	0	0	0	0	0	0	0	1	17702	709	25	4		4	ZFHX4	8	77764068	Silent	SNP	C	TCGA-CV-7407-01A-11D-2078-08	5552137	77764068	68599954	79	45365											
PTPRD	5789	broad.mit.edu	37	chr9	8507393	8507393	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagagcaaaatacttgtttCagactcaggttctgctttga	12	13	9	7	0	3	3	2	1	1	2	3	4	3	3	0	1	3	4	0	1	3	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:8507393C>G	uc003zkk.2	-	21	2296	c.1585G>C	c.(1585-1587)GAA>CAA	p.E529Q	PTPRD_uc003zkp.2_Missense_Mutation_p.E529Q|PTPRD_uc003zkq.2_Missense_Mutation_p.E529Q|PTPRD_uc003zkr.2_Missense_Mutation_p.E523Q|PTPRD_uc003zks.2_Missense_Mutation_p.E519Q|PTPRD_uc003zkl.2_Missense_Mutation_p.E529Q|PTPRD_uc003zkm.2_Missense_Mutation_p.E516Q|PTPRD_uc003zkn.2_Missense_Mutation_p.E529Q|PTPRD_uc003zko.2_Missense_Mutation_p.E526Q	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	529	Fibronectin type-III 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATACTTGTTTCAGACTCAGGT	0.448										TSP Lung(15;0.13)			7	261					0	0	0	0	G	8507393	G	G	8507393	3	3	247	1	0	0	0	0	1	0	0	0	12864	835	29	2	4321	2	PTPRD	9	8507393	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08		8507393	132706038	80	45366											
FREM1	158326	broad.mit.edu	37	chr9	14842546	14842546	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgtgacggatgctgtgatgGccatcaaatatccggaagac	11	10	12	8	2	1	3	1	2	0	1	2	5	2	5	2	3	1	1	2	3	3	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:14842546G>A	uc003zlm.2	-	9	2096	c.1506C>T	c.(1504-1506)GGC>GGT	p.G502G	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	502	CSPG 2.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TGCTGTGATGGCCATCAAATA	0.507													10	278					0	0	0	0	A	14842546	A	A	14842546	2	1	247	1	0	0	0	0	0	0	0	1	6078	1190	42	4		4	FREM1	9	14842546	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	6335153	14842546	126370885	81	45367											
KIF27	55582	broad.mit.edu	37	chr9	86495230	86495230	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	actttgattttttgctggtcCcgcttaattactgcatccag	7	17	7	10	1	0	1	0	1	0	0	2	1	2	1	2	1	3	3	2	1	2	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:86495230C>T	uc004ana.2	-	11	2769	c.2625G>A	c.(2623-2625)CGG>CGA	p.R875R	KIF27_uc010mpw.2_Intron|KIF27_uc010mpx.2_Silent_p.R875R	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	875	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TTTGCTGGTCCCGCTTAATTA	0.353													4	77					0	0	0	0	T	86495230	T	T	86495230	2	4	247	1	0	0	0	0	0	0	0	1	8335	610	22	4		4	KIF27	9	86495230	Silent	SNP	C	TCGA-CV-7407-01A-11D-2078-08	71652684	86495230	54718201	82	45368											
SECISBP2	79048	broad.mit.edu	37	chr9	91953402	91953402	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcacaaggtagtgaccttgaAcaaaatgaagcctcaagaaa	18	7	8	8	0	2	4	2	3	0	1	2	4	2	4	2	1	2	1	2	1	8	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:91953402A>T	uc004aqj.1	+	8	1199	c.1119A>T	c.(1117-1119)GAA>GAT	p.E373D	SECISBP2_uc010mqn.1_Missense_Mutation_p.E334D|SECISBP2_uc004aqi.1_Missense_Mutation_p.E261D|SECISBP2_uc011ltk.1_Missense_Mutation_p.E372D|SECISBP2_uc004aqk.1_Missense_Mutation_p.E300D|SECISBP2_uc010mqo.1_Missense_Mutation_p.E78D|SECISBP2_uc011ltl.1_Missense_Mutation_p.E305D	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	373					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						GTGACCTTGAACAAAATGAAG	0.333													8	60					0	0	0	0	T	91953402	T	T	91953402	3	4	247	1	0	0	0	0	1	0	0	0	14071	40	2	5	1149	5	SECISBP2	9	91953402	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	5458172	91953402	49260029	83	45369											
FANCC	2176	broad.mit.edu	37	chr9	97897696	97897696	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcactggagattagcttttCaaaaagatgcagcattgctt	12	13	8	8	0	2	2	2	0	0	2	2	3	2	2	0	1	4	4	0	1	3	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:97897696C>A	uc004avh.2	-	8	1037	c.775G>T	c.(775-777)GAA>TAA	p.E259*	FANCC_uc004avi.3_Nonsense_Mutation_p.E259*	NM_000136	NP_000127	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	259					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)	1		Acute lymphoblastic leukemia(62;0.138)				ATTAGCTTTTCAAAAAGATGC	0.428			D|Mis|N|F|S			AML|leukemia		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				8	39					0.000442599	0.000472286	1	0	A	97897696	A	A	97897696	4	1	247	1	0	0	0	0	0	1	0	0	5696	835	29	2	933	2	FANCC	9	97897696	Nonsense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	5944294	97897696	43315735	84	45370											
LRRC8A	56262	broad.mit.edu	37	chr9	131670584	131670584	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgctgcacctcattgacCaatacgacccgctctactcc	9	10	5	17	2	3	1	2	1	1	0	4	2	4	1	4	0	4	3	4	0	3	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:131670584C>G	uc004bwl.3	+	3	1395	c.1141C>G	c.(1141-1143)CAA>GAA	p.Q381E	LRRC8A_uc010myp.2_Missense_Mutation_p.Q381E|LRRC8A_uc010myq.2_Missense_Mutation_p.Q381E	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	381	LRR 1.				pre-B cell differentiation	integral to membrane					0						CCTCATTGACCAATACGACCC	0.562													6	65					0	0	0	0	G	131670584	G	G	131670584	3	3	247	1	0	0	0	0	1	0	0	0	9071	595	21	4	1143	4	LRRC8A	9	131670584	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	33772888	131670584	9542847	85	45371											
EHMT1	79813	broad.mit.edu	37	chr9	140637837	140637837	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttttagcttgcttgccttttGttttagcagctgcagtatct	5	20	8	8	0	1	0	0	0	1	0	1	0	1	0	1	0	6	7	1	0	3	9			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr9:140637837G>T	uc011mfc.1	+	5	875	c.838G>T	c.(838-840)GTT>TTT	p.V280F	EHMT1_uc004coa.2_Missense_Mutation_p.V280F|EHMT1_uc004cob.1_Missense_Mutation_p.V249F|EHMT1_uc010ncn.1_RNA	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	280					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		cttgccttttgttttAGCAGC	0.264													7	34					5.18039e-06	5.63086e-06	1	0	T	140637837	T	T	140637837	3	4	247	1	0	0	0	0	1	0	0	0	5005	1377	48	4	856	4	EHMT1	9	140637837	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	8967253	140637837	575594	86	45372											
PLXDC2	84898	broad.mit.edu	37	chr10	20335831	20335831	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaattactatatatctcgaAtatatggtccatctgattct	13	16	4	8	1	3	1	0	1	3	0	5	2	4	1	1	1	1	0	1	1	8	7			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr10:20335831A>G	uc001iqg.1	+	3	995	c.358A>G	c.(358-360)ATA>GTA	p.I120V	PLXDC2_uc001iqh.1_Intron	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	120	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						TATATCTCGAATATATGGTCC	0.328													11	88					0	0	0	0	G	20335831	G	G	20335831	3	3	247	1	0	0	0	0	1	0	0	0	12173	101	4	5	368	5	PLXDC2	10	20335831	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08		20335831	115198916	87	45373											
GPR158	57512	broad.mit.edu	37	chr10	25861578	25861578	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgaacttttgcttttctagGgttttgaaggtgtttctttc	5	22	9	5	0	2	2	0	2	2	0	3	2	2	2	0	2	2	3	0	2	3	10			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr10:25861578G>T	uc001isj.2	+	7	1575	c.1515G>T	c.(1513-1515)AGG>AGT	p.R505S		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	505	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GCTTTTCTAGGGTTTTGAAGG	0.368													12	67					1.5842e-08	1.76583e-08	1	0	T	25861578	T	T	25861578	3	4	247	1	0	0	0	0	1	0	0	0	6701	1246	43	4	1541	4	GPR158	10	25861578	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	5525747	25861578	109673169	88	45374											
PPYR1	5540	broad.mit.edu	37	chr10	47087866	47087866	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacagtacatacggaagtCtccaaagggtccctgaggct	11	8	10	12	1	1	1	0	1	1	0	4	2	3	2	3	3	2	2	3	3	4	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr10:47087866C>A	uc001jee.2	+	3	1502	c.1083C>A	c.(1081-1083)GTC>GTA	p.V361V	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.V361V	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	361	Cytoplasmic (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						ATACGGAAGTCTCCAAAGGGT	0.567													21	108					0.00465635	0.00480941	1	0	A	47087866	A	A	47087866	2	1	247	1	0	0	0	0	0	0	0	1	12476	900	32	2		2	PPYR1	10	47087866	Silent	SNP	C	TCGA-CV-7407-01A-11D-2078-08	21226288	47087866	88446881	89	45375											
GDF10	2662	broad.mit.edu	37	chr10	48428782	48428782	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accctcggctcatcccactgCttcctccgggctttctgcat	4	12	7	18	2	2	0	1	0	1	0	6	0	5	0	4	2	2	4	4	2	0	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr10:48428782C>T	uc001jfb.2	-	2	1560	c.1104G>A	c.(1102-1104)AAG>AAA	p.K368K	GDF10_uc009xnp.2_Silent_p.K367K|GDF10_uc009xnq.1_Silent_p.K368K	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	368					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						CATCCCACTGCTTCCTCCGGG	0.572													26	39					0	0	0	0	T	48428782	T	T	48428782	2	4	247	1	0	0	0	0	0	0	0	1	6348	796	28	4		4	GDF10	10	48428782	Silent	SNP	C	TCGA-CV-7407-01A-11D-2078-08	1340916	48428782	87105965	90	45376											
NRAP	4892	broad.mit.edu	37	chr10	115365978	115365978	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtttttgctcggatgaactCgggcagacccagggtcattg	7	11	13	10	3	1	2	1	1	0	1	3	3	1	3	1	3	2	3	1	3	1	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr10:115365978C>T	uc001laj.2	-	33	3930	c.3766G>A	c.(3766-3768)GAG>AAG	p.E1256K	NRAP_uc009xyb.2_Intron|NRAP_uc001lak.2_Missense_Mutation_p.E1221K|NRAP_uc001lal.3_Missense_Mutation_p.E1256K	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1256	Nebulin 33.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CGGATGAACTCGGGCAGACCC	0.438													20	29					0	0	0	0	T	115365978	T	T	115365978	3	4	247	1	0	0	0	0	1	0	0	0	10692	893	31	1	1466	1	NRAP	10	115365978	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	66937196	115365978	20168769	91	45377											
MRGPRX3	117195	broad.mit.edu	37	chr11	18158851	18158851	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagcttcacggggctgacGtgcatcgtttcccttgtcgc	4	12	12	13	4	1	2	1	2	0	0	4	2	2	2	1	2	2	4	1	2	0	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:18158851G>A	uc001mnu.2	+	3	463	c.102G>A	c.(100-102)ACG>ACA	p.T34T		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	34	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						CGGGGCTGACGTGCATCGTTT	0.572													16	103					0	0	0	0	A	18158851	A	A	18158851	2	1	247	1	0	0	0	0	0	0	0	1	9821	1132	40	1		1	MRGPRX3	11	18158851	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08		18158851	116847665	92	45378											
GAS2	2620	broad.mit.edu	37	chr11	22696395	22696395	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcttttgtttccaaaacaGgtattacaagtggataaata	14	14	7	6	0	1	0	0	0	1	0	2	1	2	1	1	2	2	3	1	2	8	7			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:22696395G>A	uc009yie.2	+	2	287	c.-19_splice	c.e2-1		GAS2_uc001mqm.2_Splice_Site|GAS2_uc001mqn.2_Splice_Site|GAS2_uc001mqo.2_5'UTR	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2						cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						TTCCAAAACAGGTATTACAAG	0.418													8	20					0	0	0	0	A	22696395	A	A	22696395	5	1	247	1	0	0	0	0	0	0	1	0	6280	1014	35	4		4	GAS2	11	22696395	Splice_Site	SNP	G	TCGA-CV-7407-01A-11D-2078-08	4537544	22696395	112310121	93	45379											
MRPL16	54948	broad.mit.edu	37	chr11	59575303	59575303	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaataaatctaagcttgggTttttcaggaatggaaacatc	14	13	8	6	0	3	0	2	0	1	0	4	2	3	2	0	3	2	2	0	3	6	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:59575303T>G	uc001noh.2	-	3	355	c.141A>C	c.(139-141)AAA>AAC	p.K47N		NM_017840	NP_060310	Q9NX20	RM16_HUMAN	mitochondrial ribosomal protein L16 precursor	47							rRNA binding			central_nervous_system(1)	1						TAAGCTTGGGTTTTTCAGGAA	0.368													11	160					0	0	0	0	G	59575303	G	G	59575303	3	3	247	1	0	0	0	0	1	0	0	0	9834	1722	60	5	622	5	MRPL16	11	59575303	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	36878908	59575303	75431213	94	45380											
MS4A15	219995	broad.mit.edu	37	chr11	60543106	60543106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctgccaaacgccttcaGcgcagacttcaacatcccca	10	8	5	18	2	2	1	2	0	0	1	4	1	4	1	5	0	4	1	5	0	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:60543106G>A	uc009ynf.1	+	7	861	c.641G>A	c.(640-642)AGC>AAC	p.S214N	MS4A15_uc001npx.2_Missense_Mutation_p.S121N|MS4A15_uc001npy.2_RNA|MS4A15_uc009yng.1_Missense_Mutation_p.S173N	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member	214						integral to membrane	receptor activity			lung(1)	1						AACGCCTTCAGCGCAGACTTC	0.577											OREG0020991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	156					0	0	0	0	A	60543106	A	A	60543106	3	1	247	1	0	0	0	0	1	0	0	0	9912	971	34	4	663	4	MS4A15	11	60543106	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	967803	60543106	74463410	95	45381											
AHNAK	79026	broad.mit.edu	37	chr11	62298958	62298958	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcactgacatctacttttggGcctttcaggtccccttccag	6	13	8	14	0	2	1	1	1	1	0	4	1	4	1	4	2	1	1	4	2	1	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:62298958G>A	uc001ntl.2	-	5	3231	c.2931C>T	c.(2929-2931)GGC>GGT	p.G977G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	977					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTACTTTTGGGCCTTTCAGGT	0.463													24	104					0	0	0	0	A	62298958	A	A	62298958	2	1	247	1	0	0	0	0	0	0	0	1	414	1190	42	4		4	AHNAK	11	62298958	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	1755852	62298958	72707558	96	45382											
SLC22A12	116085	broad.mit.edu	37	chr11	64361159	64361159	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtgatgaccttgaactcTctgggcttcagcttcggcca	6	13	11	11	1	2	3	1	3	1	0	4	3	2	3	2	3	2	2	2	3	1	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:64361159T>C	uc001oam.1	+	4	1461	c.714T>C	c.(712-714)TCT>TCC	p.S238S	SLC22A12_uc009ypr.1_Silent_p.S263S|SLC22A12_uc001oal.1_Silent_p.S17S|SLC22A12_uc009yps.1_Silent_p.S204S|SLC22A12_uc001oan.1_Intron|SLC22A12_uc009ypt.2_Silent_p.S56S	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	238	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CCTTGAACTCTCTGGGCTTCA	0.642													10	29					0	0	0	0	C	64361159	C	C	64361159	2	2	247	1	0	0	0	0	0	0	0	1	14508	1538	54	5		5	SLC22A12	11	64361159	Silent	SNP	T	TCGA-CV-7407-01A-11D-2078-08	2062201	64361159	70645357	97	45383											
ALKBH8	91801	broad.mit.edu	37	chr11	107427562	107427562	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actacttcttttccattgagGgtaacataggctctcttaga	10	15	7	9	0	2	2	0	1	2	1	4	2	3	2	1	2	2	2	1	2	4	8			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:107427562G>A	uc010rvr.1	-	3	372	c.297C>T	c.(295-297)ACC>ACT	p.T99T	ALKBH8_uc010rvq.1_5'UTR|ALKBH8_uc009yxp.2_Silent_p.T99T|ALKBH8_uc001pjl.2_RNA	NM_138775	NP_620130	Q96BT7	ALKB8_HUMAN	alkB, alkylation repair homolog 8	99	RRM.				response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)		TTCCATTGAGGGTAACATAGG	0.348													5	33					0	0	0	0	A	107427562	A	A	107427562	2	1	247	1	0	0	0	0	0	0	0	1	533	1219	43	4		4	ALKBH8	11	107427562	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	43066403	107427562	27578954	98	45384											
ARHGEF12	23365	broad.mit.edu	37	chr11	120346103	120346103	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgttacaaaagcaggatgAtagactggttttaaggtgtc	13	13	11	4	0	0	2	0	1	0	1	1	3	0	3	0	3	2	3	0	3	5	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:120346103A>T	uc001pxl.1	+	33	3171	c.3164A>T	c.(3163-3165)GAT>GTT	p.D1055V	ARHGEF12_uc009zat.2_Missense_Mutation_p.D1036V|ARHGEF12_uc010rzn.1_Missense_Mutation_p.D952V|ARHGEF12_uc009zau.1_Missense_Mutation_p.D952V	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1055	PH.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		AAGCAGGATGATAGACTGGTT	0.333			T	MLL	AML								8	69					0	0	0	0	T	120346103	T	T	120346103	3	4	247	1	0	0	0	0	1	0	0	0	897	333	12	5	3294	5	ARHGEF12	11	120346103	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	12918541	120346103	14660413	99	45385											
ROBO3	64221	broad.mit.edu	37	chr11	124744033	124744033	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggagacacacacagtcagcGgtctgcagcccaataccatc	12	6	9	14	1	2	1	1	0	1	1	3	2	2	1	2	2	4	1	2	2	2	1	rs74787566	by1000genomes	TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr11:124744033G>A	uc001qbc.2	+	12	2044	c.1852G>A	c.(1852-1854)GGT>AGT	p.G618S	ROBO3_uc010saq.1_5'Flank|ROBO3_uc001qbd.2_5'Flank|ROBO3_uc010sar.1_5'Flank|ROBO3_uc001qbe.2_5'Flank	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	618	Fibronectin type-III 1.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CACAGTCAGCGGTCTGCAGCC	0.587													6	73					0	0	0	0	A	124744033	A	A	124744033	3	1	247	1	0	0	0	0	1	0	0	0	13580	1116	39	1	1898	1	ROBO3	11	124744033	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	4397930	124744033	10262483	100	45386											
B4GALNT3	283358	broad.mit.edu	37	chr12	653525	653525	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccggggccgtgccaacctGcatgtgtttgaagactggtg	6	11	14	10	2	0	2	0	1	0	1	1	2	1	2	4	3	3	2	4	3	2	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr12:653525G>A	uc001qii.1	+	4	372	c.372G>A	c.(370-372)CTG>CTA	p.L124L	B4GALNT3_uc001qij.1_Silent_p.L26L	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	124	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GTGCCAACCTGCATGTGTTTG	0.632													9	75					0	0	0	0	A	653525	A	A	653525	2	1	247	1	0	0	0	0	0	0	0	1	1270	1306	46	4		4	B4GALNT3	12	653525	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08		653525	133198370	101	45387											
ZBTB39	9880	broad.mit.edu	37	chr12	57396829	57396829	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctcccccgtgtggatccGccggtggtagttgaattcgc	4	12	12	13	4	1	1	0	1	1	0	4	2	2	2	4	3	0	2	4	3	2	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr12:57396829G>A	uc001sml.1	-	2	1959	c.1873C>T	c.(1873-1875)CGG>TGG	p.R625W	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	625	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						GTGTGGATCCGCCGGTGGTAG	0.557													9	70					0	0	0	0	A	57396829	A	A	57396829	3	1	247	1	0	0	0	0	1	0	0	0	17607	1086	38	1	269	1	ZBTB39	12	57396829	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	56743304	57396829	76455066	102	45388											
TMEM132D	121256	broad.mit.edu	37	chr12	129569218	129569218	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttcatttctttcccattGacaaagacgtagtcacatct	10	15	4	12	1	4	2	2	1	2	1	5	2	5	2	2	0	0	1	2	0	2	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr12:129569218G>T	uc009zyl.1	-	6	1801	c.1473C>A	c.(1471-1473)GTC>GTA	p.V491V	TMEM132D_uc001uia.2_Silent_p.V29V	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	491	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CTTTCCCATTGACAAAGACGT	0.542													7	28					2.0095e-06	2.19789e-06	1	0	T	129569218	T	T	129569218	2	4	247	1	0	0	0	0	0	0	0	1	16113	1277	45	2		2	TMEM132D	12	129569218	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	72172389	129569218	4282677	103	45389											
ANKLE2	23141	broad.mit.edu	37	chr12	133319798	133319798	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttacaatcaaatggtgtgacGaaagcacgttgactacatct	14	11	8	8	2	2	2	1	2	1	0	2	3	2	2	0	1	3	2	0	1	5	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr12:133319798G>A	uc001ukx.2	-	6	1362	c.1295C>T	c.(1294-1296)TCG>TTG	p.S432L	ANKLE2_uc001uky.3_Missense_Mutation_p.S370L	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	432	ANK.					cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		ATGGTGTGACGAAAGCACGTT	0.353													6	25					0	0	0	0	A	133319798	A	A	133319798	3	1	247	1	0	0	0	0	1	0	0	0	633	1059	37	1	1553	1	ANKLE2	12	133319798	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	3750580	133319798	532097	104	45390											
OR4N2	390429	broad.mit.edu	37	chr14	20295720	20295720	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaatattctacttcatcaTcctccctggaaattttctca	10	18	2	11	0	4	0	3	0	2	0	7	1	6	1	2	1	1	0	2	1	4	8			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:20295720T>C	uc010tkv.1	+	1	113	c.113T>C	c.(112-114)ATC>ACC	p.I38T		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	38	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TACTTCATCATCCTCCCTGGA	0.438													20	277					0	0	0	0	C	20295720	C	C	20295720	3	2	247	1	0	0	0	0	1	0	0	0	11131	1435	50	5	115	5	OR4N2	14	20295720	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08		20295720	87053820	105	45391											
OR4K17	390436	broad.mit.edu	37	chr14	20586188	20586188	+	Frame_Shift_Del	DEL	T	-	-																															tcccaatgtggtagacagcaTtttttgtgacctccctttgg																										TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:20586188delT	uc001vwo.1	+	1	623	c.623delT	c.(622-624)ATTfs	p.I208fs		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GTAGACAGCATTTTTTGTGAC	0.448													---	---	---								-	20586188	-	-	20586188	7	5	247	1	0	1	0	1	0	0	0	0	11125	1493	52	0	625	0	OR4K17	14	20586188	Frame_Shift_Del	DEL	T	TCGA-CV-7407-01A-11D-2078-08	290468	20586188	86763352	106	45392											
METTL3	56339	broad.mit.edu	37	chr14	21971333	21971333	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	taccttcttgctctgttgttCcttagtggactgttggttca	4	19	9	9	0	3	0	1	0	2	0	4	1	4	1	2	2	2	5	2	2	2	8			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:21971333C>T	uc001wbc.2	-	3	798	c.706G>A	c.(706-708)GAA>AAA	p.E236K	METTL3_uc001wbb.2_Missense_Mutation_p.E81K|METTL3_uc010tlw.1_RNA|METTL3_uc010tlx.1_Missense_Mutation_p.E236K|METTL3_uc001wbd.1_Missense_Mutation_p.E236K	NM_019852	NP_062826	Q86U44	MTA70_HUMAN	methyltransferase like 3	236					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			pancreas(1)|skin(1)	2	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		CTCTGTTGTTCCTTAGTGGAC	0.448													38	114					0	0	0	0	T	21971333	T	T	21971333	3	4	247	1	0	0	0	0	1	0	0	0	9554	864	30	2	1072	2	METTL3	14	21971333	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	1385145	21971333	85378207	107	45393											
RTN1	6252	broad.mit.edu	37	chr14	60212930	60212930	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccgtggactctgcaggagTcatctctattccagaatcag	9	12	9	11	1	4	1	2	0	2	1	7	3	6	3	2	2	1	1	2	2	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:60212930T>C	uc001xen.1	-	2	720	c.511A>G	c.(511-513)ACT>GCT	p.T171A		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	171					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TCTGCAGGAGTCATCTCTATT	0.507													32	36					0	0	0	0	C	60212930	C	C	60212930	3	2	247	1	0	0	0	0	1	0	0	0	13790	1667	58	5	1916	5	RTN1	14	60212930	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	38241597	60212930	47136610	108	45394											
SYNE2	23224	broad.mit.edu	37	chr14	64486767	64486767	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttctagaagagtggctgaaAtacagtttttgctccaaagc	12	13	9	7	0	1	3	0	1	1	2	2	3	2	3	1	1	3	3	1	1	5	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:64486767A>G	uc001xgm.2	+	35	5337	c.5107A>G	c.(5107-5109)ATA>GTA	p.I1703V	SYNE2_uc001xgl.2_Missense_Mutation_p.I1703V	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1703	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGTGGCTGAAATACAGTTTTT	0.249													14	72					0	0	0	0	G	64486767	G	G	64486767	3	3	247	1	0	0	0	0	1	0	0	0	15512	101	4	5	5241	5	SYNE2	14	64486767	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	4273837	64486767	42862773	109	45395											
ITPK1	3705	broad.mit.edu	37	chr14	93412779	93412779	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtgcctgccgcagggcccgGgagagctcccggatgacctc	6	5	15	15	3	0	2	0	1	0	1	2	4	1	3	5	3	3	2	5	3	0	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr14:93412779G>A	uc001ybg.2	-	10	1087	c.798C>T	c.(796-798)TCC>TCT	p.S266S	ITPK1_uc001ybe.2_Silent_p.S266S|ITPK1_uc001ybf.2_Silent_p.S147S|ITPK1_uc001ybh.2_Silent_p.S266S	NM_014216	NP_055031	Q13572	ITPK1_HUMAN	inositol 1,3,4-triphosphate 5/6 kinase isoform	266	ATP-grasp.				blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding				0		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		GCAGGGCCCGGGAGAGCTCCC	0.617													12	43					0	0	0	0	A	93412779	A	A	93412779	2	1	247	1	0	0	0	0	0	0	0	1	7955	1219	43	4		4	ITPK1	14	93412779	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	28926012	93412779	13936761	110	45396											
CASC5	57082	broad.mit.edu	37	chr15	40915007	40915010	+	Frame_Shift_Del	DEL	GGAA	-	-																															agcaaaatgtcaaaatttggGgaaggaaaagtgttggtgga																										TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr15:40915007_40915010delGGAA	uc010bbs.1	+	11	2784_2787	c.2623_2626delGGAA	c.(2623-2628)GGAAGGfs	p.G875fs	CASC5_uc010ucq.1_Frame_Shift_Del_p.G699fs|CASC5_uc001zme.2_Frame_Shift_Del_p.G849fs|CASC5_uc010bbt.1_Frame_Shift_Del_p.G849fs	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	875_876	2 X 104 AA approximate repeats.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		CAAAATTTGGGGAAGGAAAAGTGT	0.319													---	---	---								-	40915010	-	-	40915007	7	5	247	1	0	1	0	1	0	0	0	0	2675	1233	43	0	2661	0	CASC5	15	40915007	Frame_Shift_Del	DEL	GGAA	TCGA-CV-7407-01A-11D-2078-08		40915007	61616385	111	45397											
VPS33B	26276	broad.mit.edu	37	chr15	91557634	91557634	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggcaatgtatcgcatattcTtgatgcggggtctgaccaag	9	12	12	8	2	2	2	0	2	2	0	3	2	2	2	1	3	1	3	1	3	4	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr15:91557634T>C	uc002bqp.1	-	4	623	c.269A>G	c.(268-270)AAG>AGG	p.K90R	VPS33B_uc002bqq.1_5'UTR|VPS33B_uc010uqu.1_Missense_Mutation_p.K63R	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	90					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					TCGCATATTCTTGATGCGGGG	0.428													33	144					0	0	0	0	C	91557634	C	C	91557634	3	2	247	1	0	0	0	0	1	0	0	0	17270	1609	56	5	1664	5	VPS33B	15	91557634	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	50642627	91557634	10973758	112	45398											
MSLNL	401827	broad.mit.edu	37	chr16	830539	830539	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgtaggtgacagtgtgcaCgggtaggtgacagtgtgcac	9	9	16	7	1	0	2	0	2	0	0	0	2	0	2	0	3	2	4	0	3	2	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr16:830539C>T	uc002cjz.1	-	3	462	c.462G>A	c.(460-462)CCG>CCA	p.P154P		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:Variant_position_missing_in_Q96KJ4_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4						ACAGTGTGCACGGGTAGGTGA	0.562													12	93					0	0	0	0	T	830539	T	T	830539	2	4	247	1	0	0	0	0	0	0	0	1	9935	523	19	1		1	MSLNL	16	830539	Silent	SNP	C	TCGA-CV-7407-01A-11D-2078-08		830539	89524214	113	45399											
TNRC6A	27327	broad.mit.edu	37	chr16	24826581	24826581	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caataggagatggctggccaCgtgccaaatcgcctaacggc	11	6	12	12	3	0	1	0	0	0	1	1	2	0	1	3	4	2	1	3	4	4	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr16:24826581C>T	uc002dmm.2	+	19	4900	c.4786C>T	c.(4786-4788)CGT>TGT	p.R1596C	TNRC6A_uc010bxs.2_Missense_Mutation_p.R1343C|TNRC6A_uc002dmn.2_Missense_Mutation_p.R1294C|TNRC6A_uc002dmo.2_Missense_Mutation_p.R1235C|TNRC6A_uc002dmp.2_Missense_Mutation_p.R197C|TNRC6A_uc002dmq.2_Missense_Mutation_p.R263C	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1596					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TGGCTGGCCACGTGCCAAATC	0.448													7	31					0	0	0	0	T	24826581	T	T	24826581	3	4	247	1	0	0	0	0	1	0	0	0	16406	536	19	1	4860	1	TNRC6A	16	24826581	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	23996042	24826581	65528172	114	45400											
CDH16	1014	broad.mit.edu	37	chr16	66945163	66945163	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggactgggcggtgtgcacctCcccggagaatttctcaatgc	7	9	13	12	2	1	1	1	0	1	1	3	3	2	2	3	4	2	1	3	4	2	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr16:66945163C>T	uc002eql.2	-	14	1919	c.1846G>A	c.(1846-1848)GAG>AAG	p.E616K	CDH16_uc010cdy.2_Missense_Mutation_p.E616K|CDH16_uc002eqm.2_Missense_Mutation_p.E519K	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	616	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GTGTGCACCTCCCCGGAGAAT	0.597													3	18					0	0	0	0	T	66945163	T	T	66945163	3	4	247	1	0	0	0	0	1	0	0	0	3116	864	30	2	663	2	CDH16	16	66945163	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	42118582	66945163	23409590	115	45401											
PMFBP1	83449	broad.mit.edu	37	chr16	72173223	72173223	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acactcttctgaggagctagGagggtatctgtgggtggctg	7	11	16	7	0	3	1	0	1	3	0	3	3	3	3	0	5	1	3	0	5	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr16:72173223G>A	uc002fcc.3	-	7	1055	c.883C>T	c.(883-885)CCT>TCT	p.P295S	PMFBP1_uc002fcd.2_Missense_Mutation_p.P295S|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.P150S	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	295										ovary(2)	2		Ovarian(137;0.179)				GAGGAGCTAGGAGGGTATCTG	0.463													4	15					0	0	0	0	A	72173223	A	A	72173223	3	1	247	1	0	0	0	0	1	0	0	0	12189	1174	41	2	2260	2	PMFBP1	16	72173223	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	5228060	72173223	18181530	116	45402											
PKD1L2	114780	broad.mit.edu	37	chr16	81142842	81142842	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgaaggctgaccatcgtcTccgccgcatcaaagagggtt	9	8	12	12	3	2	3	1	2	1	1	4	3	2	3	3	2	0	4	3	2	2	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr16:81142842T>C	uc002fgh.1	-	43	7043	c.7043A>G	c.(7042-7044)GAG>GGG	p.E2348G	PKD1L2_uc002fgf.1_Missense_Mutation_p.E148G|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2348	Channel pore-region.|Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GACCATCGTCTCCGCCGCATC	0.398													4	9					0	0	0	0	C	81142842	C	C	81142842	3	2	247	1	0	0	0	0	1	0	0	0	12020	1551	54	5	348	5	PKD1L2	16	81142842	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	8969619	81142842	9211911	117	45403											
SLC25A35	399512	broad.mit.edu	37	chr17	8197904	8197904	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtcggatgccattcatcagGaactggtacaagagggcggg	11	7	15	8	2	2	1	2	0	0	1	3	3	2	3	1	5	3	1	1	5	3	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:8197904G>A	uc002gla.3	-	1	267	c.222C>T	c.(220-222)TTC>TTT	p.F74F	SLC25A35_uc002gku.1_Silent_p.F74F|SLC25A35_uc002gkt.2_Silent_p.F74F|SLC25A35_uc002gkz.1_RNA	NM_201520	NP_958928	Q3KQZ1	S2535_HUMAN	solute carrier family 25, member 35	74	Solcar 1.|Helical; Name=2; (Potential).				transport	integral to membrane|mitochondrial inner membrane					0						CATTCATCAGGAACTGGTACA	0.627													9	37					0	0	0	0	A	8197904	A	A	8197904	2	1	247	1	0	0	0	0	0	0	0	1	14563	1165	41	2		2	SLC25A35	17	8197904	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08		8197904	72997306	118	45404											
MYH8	4626	broad.mit.edu	37	chr17	10296168	10296168	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggcctccagtttctggaTctgcttcttcccacccttca	4	14	6	17	0	4	0	1	0	3	0	6	1	6	1	5	2	1	2	5	2	0	4			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:10296168T>C	uc002gmm.2	-	37	5538	c.5443A>G	c.(5443-5445)ATC>GTC	p.I1815V	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1815	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						AGTTTCTGGATCTGCTTCTTC	0.552									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				18	121					0	0	0	0	C	10296168	C	C	10296168	3	2	247	1	0	0	0	0	1	0	0	0	10094	1435	50	5	386	5	MYH8	17	10296168	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	2098264	10296168	70899042	119	45405											
NCOR1	9611	broad.mit.edu	37	chr17	15971267	15971267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgcgtgggcaggtggctcCgataaacctcgcctgcagtg	7	8	15	11	3	0	0	0	0	0	0	2	1	1	0	3	3	3	3	3	3	2	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:15971267C>T	uc002gpo.2	-	32	4922	c.4682G>A	c.(4681-4683)CGG>CAG	p.R1561Q	NCOR1_uc002gpn.2_Missense_Mutation_p.R1577Q|NCOR1_uc002gpm.2_Missense_Mutation_p.R82Q|NCOR1_uc010vwb.1_Missense_Mutation_p.R145Q|NCOR1_uc010coy.2_Missense_Mutation_p.R469Q|NCOR1_uc010vwc.1_Missense_Mutation_p.R372Q	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1561	Interaction with ETO.|Interaction with C1D (By similarity).			R -> W (in Ref. 1; AAC33550).	cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAGGTGGCTCCGATAAACCTC	0.512													9	40					0	0	0	0	T	15971267	T	T	15971267	3	4	247	1	0	0	0	0	1	0	0	0	10289	652	23	1	2700	1	NCOR1	17	15971267	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	5675099	15971267	65223943	120	45406											
MYO15A	51168	broad.mit.edu	37	chr17	18052259	18052259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcagccagcaggggaggcCccaaagtgtaggtagctatg	10	6	15	10	0	0	0	0	0	0	0	0	1	0	1	3	4	4	5	3	4	4	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:18052259C>T	uc010vxh.1	+	32	7287	c.6949C>T	c.(6949-6951)CCC>TCC	p.P2317S		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2317	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CAGGGGAGGCCCCAAAGTGTA	0.642													2	4					0	0	0	0	T	18052259	T	T	18052259	3	4	247	1	0	0	0	0	1	0	0	0	10116	623	22	4	7071	4	MYO15A	17	18052259	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	2080992	18052259	63142951	121	45407											
ACCN1	40	broad.mit.edu	37	chr17	32483504	32483504	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgttggcaaagatctggatGctagaaggttgcaggctgcc	9	10	15	7	0	1	2	0	0	1	2	1	3	1	3	1	4	3	6	1	4	3	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:32483504G>A	uc002hhu.2	-	1	322	c.48C>T	c.(46-48)AGC>AGT	p.S16S		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	16	Cytoplasmic (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	AGATCTGGATGCTAGAAGGTT	0.587													14	25					0	0	0	0	A	32483504	A	A	32483504	2	1	247	1	0	0	0	0	0	0	0	1	128	1310	46	4		4	ACCN1	17	32483504	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	14431245	32483504	48711706	122	45408											
C17orf66	256957	broad.mit.edu	37	chr17	34185484	34185484	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctaggatggccttgatgaCtggggctgagtgcacgtgca	7	10	16	8	1	1	3	0	3	1	0	1	4	1	4	1	4	2	3	1	4	1	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:34185484C>T	uc002hke.1	-	10	1134	c.985G>A	c.(985-987)GTC>ATC	p.V329I	C17orf66_uc010wck.1_RNA|C17orf66_uc010wcl.1_Missense_Mutation_p.V289I|C17orf66_uc010wcm.1_Missense_Mutation_p.V295I	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957	329							binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GCCTTGATGACTGGGGCTGAG	0.572													3	24					0	0	0	0	T	34185484	T	T	34185484	3	4	247	1	0	0	0	0	1	0	0	0	1881	565	20	4	751	4	C17orf66	17	34185484	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	1701980	34185484	47009726	123	45409											
ACACA	31	broad.mit.edu	37	chr17	35600372	35600372	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgatagacttctccacattgGggggaatgcggccagacaca	11	8	12	10	1	1	3	0	1	1	2	2	4	1	4	2	4	1	0	2	4	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:35600372G>T	uc002hnm.2	-	22	2926	c.2735C>A	c.(2734-2736)CCC>CAC	p.P912H	ACACA_uc002hnk.2_Missense_Mutation_p.P834H|ACACA_uc002hnl.2_Missense_Mutation_p.P854H|ACACA_uc002hnn.2_Missense_Mutation_p.P912H|ACACA_uc002hno.2_Missense_Mutation_p.P949H|ACACA_uc010cuz.2_Missense_Mutation_p.P912H	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	912					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTCCACATTGGGGGGAATGCG	0.468													20	128					1.33834e-09	1.51103e-09	1	0	T	35600372	T	T	35600372	3	4	247	1	0	0	0	0	1	0	0	0	106	1232	43	4	4445	4	ACACA	17	35600372	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	1414888	35600372	45594838	124	45410											
CACNG5	27091	broad.mit.edu	37	chr17	64876725	64876725	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcagcctcttcttcatgtTcattgggtttatcctgaaca	7	16	8	10	0	5	1	3	1	2	0	6	1	6	1	2	2	2	2	2	2	2	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr17:64876725T>G	uc010wqi.1	+	4	572	c.335T>G	c.(334-336)TTC>TGC	p.F112C	CACNG5_uc002jfr.2_Missense_Mutation_p.F112C|CACNG5_uc010wqj.1_Missense_Mutation_p.F112C	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	112	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			TTCTTCATGTTCATTGGGTTT	0.512													21	78					0	0	0	0	G	64876725	G	G	64876725	3	3	247	1	0	0	0	0	1	0	0	0	2572	1783	62	5	345	5	CACNG5	17	64876725	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	29276353	64876725	16318485	125	45411											
POTEC	388468	broad.mit.edu	37	chr18	14542833	14542833	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccctgcagcaggggaagcAgtgacagcaccacttgccca	10	4	11	16	0	0	1	0	1	0	0	0	2	0	2	4	2	5	4	4	2	1	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr18:14542833A>C	uc010dln.2	-	1	767	c.313T>G	c.(313-315)TGC>GGC	p.C105G	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	105										skin(3)	3						CAGGGGAAGCAGTGACAGCAC	0.617													11	147					0	0	0	0	C	14542833	C	C	14542833	3	2	247	1	0	0	0	0	1	0	0	0	12317	188	7	5	1359	5	POTEC	18	14542833	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08		14542833	63534415	126	45412											
ONECUT2	9480	broad.mit.edu	37	chr18	55143819	55143819	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggagatgcagatcaccatttCccagcagctgggcctggagc	9	7	13	12	0	1	2	1	0	0	2	2	4	2	3	3	3	4	3	3	3	0	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr18:55143819C>T	uc002lgo.2	+	2	1411	c.1379C>T	c.(1378-1380)TCC>TTC	p.S460F		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	460	Homeobox.				organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		ATCACCATTTCCCAGCAGCTG	0.582													15	39					0	0	0	0	T	55143819	T	T	55143819	3	4	247	1	0	0	0	0	1	0	0	0	10923	855	30	2	1385	2	ONECUT2	18	55143819	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	40600986	55143819	22933429	127	45413											
MYO1F	4542	broad.mit.edu	37	chr19	8618065	8618065	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcacagtcttggcgttgccGaaggcctcgagcagcgggtt	6	8	15	12	5	1	0	0	0	1	0	2	2	1	0	2	3	3	4	2	3	1	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr19:8618065G>A	uc002mkg.2	-	6	576	c.462C>T	c.(460-462)TTC>TTT	p.F154F	MYO1F_uc002mkh.2_Silent_p.F154F|MYO1F_uc010xkf.1_Silent_p.F154F	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	154	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						TGGCGTTGCCGAAGGCCTCGA	0.567													8	67					0	0	0	0	A	8618065	A	A	8618065	2	1	247	1	0	0	0	0	0	0	0	1	10126	1049	37	1		1	MYO1F	19	8618065	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08		8618065	50510918	128	45414											
PBX4	80714	broad.mit.edu	37	chr19	19681616	19681616	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgggcgtcagggggatcttCgtcttgaatgccacggatgc	6	10	15	10	3	3	1	1	1	2	0	4	3	3	3	1	4	2	0	1	4	1	2	rs147300531		TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr19:19681616C>T	uc002nmy.2	-	3	221	c.220G>A	c.(220-222)GAA>AAA	p.E74K	PBX4_uc010xqz.1_RNA|PBX4_uc010xra.1_5'UTR	NM_025245	NP_079521	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	74							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						GGGGGATCTTCGTCTTGAATG	0.537													7	65					0	0	0	0	T	19681616	T	T	19681616	3	4	247	1	0	0	0	0	1	0	0	0	11549	893	31	1	928	1	PBX4	19	19681616	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	11063551	19681616	39447367	129	45415											
ZNF585B	92285	broad.mit.edu	37	chr19	37677052	37677052	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgcatacatagggcttttCtcctgtgtgaattcgtttat	8	18	8	7	1	1	1	0	1	1	0	3	1	1	1	1	1	2	3	1	1	4	8			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr19:37677052C>T	uc002ofq.2	-	5	1641	c.1387G>A	c.(1387-1389)GAA>AAA	p.E463K	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.E277K	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TAGGGCTTTTCTCCTGTGTGA	0.368													17	296					0	0	0	0	T	37677052	T	T	37677052	3	4	247	1	0	0	0	0	1	0	0	0	18085	922	32	2	926	2	ZNF585B	19	37677052	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	17995436	37677052	21451931	130	45416											
ZNF383	163087	broad.mit.edu	37	chr19	37726884	37726884	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttttctcgtgagcaggacTttacactcctaagcctcaag	9	13	7	12	1	3	1	1	1	2	0	5	2	4	2	2	1	3	1	2	1	3	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr19:37726884T>G	uc002oft.1	+	7	720	c.140T>G	c.(139-141)CTT>CGT	p.L47R	ZNF383_uc002ofs.1_5'UTR|ZNF383_uc002ofu.1_Missense_Mutation_p.L47R	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGAGCAGGACTTTACACTCCT	0.483													9	153					0	0	0	0	G	37726884	G	G	37726884	3	3	247	1	0	0	0	0	1	0	0	0	17941	1609	56	5	150	5	ZNF383	19	37726884	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	49832	37726884	21402099	131	45417											
SLC17A7	57030	broad.mit.edu	37	chr19	49933917	49933917	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcgtcactgccagccagctgGtcatggccaacgaagccaca	10	6	10	15	2	2	0	2	0	0	0	3	1	2	0	4	2	5	1	4	2	2	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr19:49933917G>A	uc002pnp.2	-	12	1714	c.1542C>T	c.(1540-1542)GAC>GAT	p.D514D	SLC17A7_uc002pno.2_Silent_p.D176D	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	514	Cytoplasmic (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		CAGCCAGCTGGTCATGGCCAA	0.627													11	47					0	0	0	0	A	49933917	A	A	49933917	2	1	247	1	0	0	0	0	0	0	0	1	14487	1252	44	4		4	SLC17A7	19	49933917	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	12207033	49933917	9195066	132	45418											
NINL	22981	broad.mit.edu	37	chr20	25477346	25477346	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtggagtggcagtcgtcCatctctttcacaaactccag	9	10	11	11	1	2	0	1	0	1	0	6	1	4	1	2	3	1	1	2	3	1	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr20:25477346C>T	uc002wux.1	-	10	1337	c.1263G>A	c.(1261-1263)ATG>ATA	p.M421I	NINL_uc010gdn.1_Missense_Mutation_p.M421I|NINL_uc010gdo.1_Missense_Mutation_p.M204I|NINL_uc010ztf.1_Missense_Mutation_p.M437I	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	421	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GGCAGTCGTCCATCTCTTTCA	0.602													6	37					0	0	0	0	T	25477346	T	T	25477346	3	4	247	1	0	0	0	0	1	0	0	0	10474	594	21	4	2945	4	NINL	20	25477346	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08		25477346	37548174	133	45419											
ERG	2078	broad.mit.edu	37	chr21	39947591	39947591	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagacgggacttaccttgaTatgagctgctgggtccggga	9	9	14	9	2	0	3	0	2	0	1	1	5	1	5	2	3	3	2	2	3	3	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr21:39947591T>C	uc010gnw.2	-	3	329	c.34A>G	c.(34-36)ATC>GTC	p.I12V	ERG_uc010gnv.2_Translation_Start_Site|ERG_uc010gnx.2_Missense_Mutation_p.I12V|ERG_uc011ael.1_Missense_Mutation_p.I12V|ERG_uc002yxb.2_Missense_Mutation_p.I12V|ERG_uc002yxc.3_Missense_Mutation_p.I12V|ERG_uc010gnz.2_RNA	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	12					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CTTACCTTGATATGAGCTGCT	0.507													3	29					0	0	0	0	C	39947591	C	C	39947591	3	2	247	1	0	0	0	0	1	0	0	0	5246	1406	49	5	1488	5	ERG	21	39947591	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08		39947591	8182304	134	45420											
DSCAM	1826	broad.mit.edu	37	chr21	41496129	41496129	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttaccaacttactgtgggaTaggggtgggagcagaataca	12	10	13	6	0	0	1	0	0	0	1	0	3	0	3	1	4	5	1	1	4	6	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr21:41496129T>C	uc002yyq.1	-	20	4141	c.3689A>G	c.(3688-3690)TAT>TGT	p.Y1230C	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1230	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TACTGTGGGATAGGGGTGGGA	0.552													15	133					0	0	0	0	C	41496129	C	C	41496129	3	2	247	1	0	0	0	0	1	0	0	0	4790	1406	49	5	2405	5	DSCAM	21	41496129	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	1548538	41496129	6633766	135	45421											
DSCAM	1826	broad.mit.edu	37	chr21	41711195	41711195	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatcatctggctgatgcggTgactgccacccttgagaatc	8	11	11	11	1	2	4	1	4	1	1	3	5	2	4	2	2	2	1	2	2	1	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr21:41711195T>C	uc002yyq.1	-	7	1810	c.1358A>G	c.(1357-1359)CAC>CGC	p.H453R	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	453	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCTGATGCGGTGACTGCCACC	0.607													3	36					0	0	0	0	C	41711195	C	C	41711195	3	2	247	1	0	0	0	0	1	0	0	0	4790	1696	59	5	4788	5	DSCAM	21	41711195	Missense_Mutation	SNP	T	TCGA-CV-7407-01A-11D-2078-08	215066	41711195	6418700	136	45422											
PFKL	5211	broad.mit.edu	37	chr21	45730967	45730967	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctccaacatcatccagctgGtgaggcctgggaacgcggat	9	8	12	12	2	2	1	1	1	1	0	4	3	3	3	3	4	3	1	3	4	2	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr21:45730967G>T	uc002zel.2	+	3	296	c.237_splice	c.e3+1	p.L79_splice	PFKL_uc002zek.2_Splice_Site_p.L126_splice|PFKL_uc011afd.1_Splice_Site_p.L126_splice	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase						fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		CATCCAGCTGGTGAGGCCTGG	0.483													6	20					3.59834e-05	3.88709e-05	1	0	T	45730967	T	T	45730967	5	4	247	1	0	0	0	0	0	0	1	0	11819	1275	44	4	248	4	PFKL	21	45730967	Splice_Site	SNP	G	TCGA-CV-7407-01A-11D-2078-08	4019772	45730967	2398928	137	45423											
GGTLC2	91227	broad.mit.edu	37	chr22	22988944	22988944	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	actgctcacctgtctgtcgtCgcagaggacggcagtgctgt	6	10	13	12	3	2	1	1	0	1	1	4	2	2	2	1	2	2	4	1	2	0	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr22:22988944C>G	uc010gtt.2	+	1	163	c.129C>G	c.(127-129)GTC>GTG	p.V43V	LOC96610_uc011aim.1_Intron|POM121L1P_uc011ait.1_5'Flank|GGTLC2_uc010gts.2_Silent_p.V43V	NM_199127	NP_954578	Q14390	GGTL2_HUMAN	gamma-glutamyltransferase-like 4 isoform 1	43					glutathione biosynthetic process		gamma-glutamyltransferase activity			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		TGTCTGTCGTCGCAGAGGACG	0.652													2	7					0	0	0	0	G	22988944	G	G	22988944	2	3	247	1	0	0	0	0	0	0	0	1	6403	871	31	3		3	GGTLC2	22	22988944	Silent	SNP	C	TCGA-CV-7407-01A-11D-2078-08		22988944	28315622	138	45424											
SFI1	9814	broad.mit.edu	37	chr22	32011159	32011159	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccctgcctggggccctgtCaagcgcccctggcccgaagc	4	5	12	20	2	1	0	1	0	0	0	1	1	1	0	7	3	3	0	7	3	2	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr22:32011159C>G	uc003ale.2	+	29	3587	c.3194C>G	c.(3193-3195)TCA>TGA	p.S1065*	SFI1_uc003alf.2_Nonsense_Mutation_p.S1034*|SFI1_uc003alg.2_Nonsense_Mutation_p.S983*|SFI1_uc011alp.1_Nonsense_Mutation_p.S971*|SFI1_uc011alq.1_Nonsense_Mutation_p.S1010*|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA|SFI1_uc003ali.2_Nonsense_Mutation_p.S157*|SFI1_uc003alj.2_Nonsense_Mutation_p.S199*	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	1065					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						GGGGCCCTGTCAAGCGCCCCT	0.716													6	29					0	0	0	0	G	32011159	G	G	32011159	4	3	247	1	0	0	0	0	0	1	0	0	14221	838	29	2	3304	2	SFI1	22	32011159	Nonsense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	9022215	32011159	19293407	139	45425											
SLC5A4	6527	broad.mit.edu	37	chr22	32650129	32650129	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaacttcgatccacttacCggccaccaggccatatcacg	12	7	7	15	3	1	0	1	0	0	0	3	2	2	0	5	2	2	0	5	2	4	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chr22:32650129C>T	uc003ami.2	-	2	209	c.207G>A	c.(205-207)CCG>CCA	p.P69P		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	69	Helical; (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						ATCCACTTACCGGCCACCAGG	0.403													29	35					0	0	0	0	T	32650129	T	T	32650129	2	4	247	1	0	0	0	0	0	0	0	1	14731	666	23	1		1	SLC5A4	22	32650129	Silent	SNP	C	TCGA-CV-7407-01A-11D-2078-08	638970	32650129	18654437	140	45426											
RS1	6247	broad.mit.edu	37	chrX	18660205	18660205	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccagcgggatgaggcggatGaagcgggagatgatgggggg	9	4	22	6	3	0	4	0	3	0	1	0	7	0	6	1	7	2	0	1	7	1	0			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:18660205G>A	uc004cyo.2	-	6	629	c.594C>T	c.(592-594)TTC>TTT	p.F198F	CDKL5_uc004cym.2_Intron|CDKL5_uc004cyn.2_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein	198	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					TGAGGCGGATGAAGCGGGAGA	0.617													11	48					0	0	0	0	A	18660205	A	A	18660205	2	1	247	1	0	0	0	0	0	0	0	1	13758	1281	45	2		2	RS1	23	18660205	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08		18660205	136610355	141	45427											
MBTPS2	51360	broad.mit.edu	37	chrX	21896226	21896226	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctcacagatgtgtgcttttCctacagaaataattttaata	13	15	5	8	0	1	2	1	0	0	2	2	2	2	2	2	0	2	1	2	0	5	7			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:21896226C>A	uc004dae.2	+	8	1234	c.1037C>A	c.(1036-1038)TCC>TAC	p.S346Y	MBTPS2_uc010nfr.2_Intron	NM_015884	NP_056968	O43462	MBTP2_HUMAN	membrane-bound transcription factor peptidase,	346	Cys-rich.|Lumenal (Probable).				cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity			ovary(1)	1						GTGTGCTTTTCCTACAGAAAT	0.343													8	44					0.000157383	0.00016897	1	0	A	21896226	A	A	21896226	3	1	247	1	0	0	0	0	1	0	0	0	9415	855	30	2	1067	2	MBTPS2	23	21896226	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	3236021	21896226	133374334	142	45428											
SUV39H1	6839	broad.mit.edu	37	chrX	48564702	48564702	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggggccagatctacgaccGtcagggcgccacctacctct	7	6	12	16	4	3	1	1	0	2	1	3	2	3	1	5	3	2	0	5	3	2	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:48564702G>A	uc004dkn.2	+	4	920	c.875G>A	c.(874-876)CGT>CAT	p.R292H	SUV39H1_uc011mmf.1_Missense_Mutation_p.R303H|SUV39H1_uc011mmg.1_RNA	NM_003173	NP_003164	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1	292	Mediates interaction with MECOM (By similarity).|SET.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding				0						ATCTACGACCGTCAGGGCGCC	0.582													4	45					0	0	0	0	A	48564702	A	A	48564702	3	1	247	1	0	0	0	0	1	0	0	0	15478	1145	40	1	889	1	SUV39H1	23	48564702	Missense_Mutation	SNP	G	TCGA-CV-7407-01A-11D-2078-08	26668476	48564702	106705858	143	45429											
DGKK	139189	broad.mit.edu	37	chrX	50134545	50134545	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acacgagccagatcattgccGgttccaagtgggatgactgc	10	8	12	11	2	1	2	1	1	0	1	2	4	2	3	3	2	3	1	3	2	1	2			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:50134545G>A	uc010njr.1	-	11	1794	c.1734C>T	c.(1732-1734)ACC>ACT	p.T578T		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	578	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					GATCATTGCCGGTTCCAAGTG	0.512													7	45					0	0	0	0	A	50134545	A	A	50134545	2	1	247	1	0	0	0	0	0	0	0	1	4494	1103	39	1		1	DGKK	23	50134545	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	1569843	50134545	105136015	144	45430											
ARR3	407	broad.mit.edu	37	chrX	69496004	69496004	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gattggtctgacgttccgaaAagatctgtatgtgcagaccc	10	11	11	9	2	2	3	0	1	2	2	3	5	3	3	2	1	1	3	2	1	3	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:69496004A>T	uc004dyb.2	+	6	286	c.218A>T	c.(217-219)AAA>ATA	p.K73I	ARR3_uc004dya.2_Missense_Mutation_p.K73I	NM_004312	NP_004303	P36575	ARRC_HUMAN	arrestin 3, retinal (X-arrestin)	73					signal transduction|visual perception	cytoplasm|soluble fraction				large_intestine(2)|ovary(2)	4						ACGTTCCGAAAAGATCTGTAT	0.542													6	20					0	0	0	0	T	69496004	T	T	69496004	3	4	247	1	0	0	0	0	1	0	0	0	981	14	1	5	236	5	ARR3	23	69496004	Missense_Mutation	SNP	A	TCGA-CV-7407-01A-11D-2078-08	19361459	69496004	85774556	145	45431											
TCEAL8	90843	broad.mit.edu	37	chrX	102508843	102508843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtacatcctccaaagggCgatcttcctcggcctttggc	6	11	11	13	2	1	0	0	0	1	0	5	1	4	0	4	4	1	1	4	4	2	3			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:102508843C>T	uc004ejx.2	-	3	292	c.65G>A	c.(64-66)CGC>CAC	p.R22H	TCEAL8_uc004ejy.2_Missense_Mutation_p.R22H	NM_153333	NP_699164	Q8IYN2	TCAL8_HUMAN	transcription elongation factor A (SII)-like 8	22					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						CTCCAAAGGGCGATCTTCCTC	0.443													9	139					0	0	0	0	T	102508843	T	T	102508843	3	4	247	1	0	0	0	0	1	0	0	0	15743	768	27	1	292	1	TCEAL8	23	102508843	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	33012839	102508843	52761717	146	45432											
ATP1B4	23439	broad.mit.edu	37	chrX	119509241	119509241	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttaggttataatgacagtCttcaagaggaaatgaatgta	15	13	9	4	0	2	3	1	2	1	1	2	4	2	4	0	2	0	2	0	2	7	6			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:119509241C>G	uc004esr.2	+	5	661	c.577C>G	c.(577-579)CTT>GTT	p.L193V	ATP1B4_uc004esq.2_Missense_Mutation_p.L189V|ATP1B4_uc011mtx.1_Missense_Mutation_p.L158V|ATP1B4_uc011mty.1_Missense_Mutation_p.L150V	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	193	Perinuclear space (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						TAATGACAGTCTTCAAGAGGA	0.488													10	80					0	0	0	0	G	119509241	G	G	119509241	3	3	247	1	0	0	0	0	1	0	0	0	1137	913	32	2	595	2	ATP1B4	23	119509241	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	17000398	119509241	35761319	147	45433											
GPR112	139378	broad.mit.edu	37	chrX	135431431	135431431	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctccaaagacctctcctcctCccacatcccaaatggttgaa	11	9	4	17	0	1	2	0	1	1	1	6	2	5	2	6	1	0	1	6	1	3	1			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:135431431C>G	uc004ezu.1	+	6	5857	c.5566C>G	c.(5566-5568)CCC>GCC	p.P1856A	GPR112_uc010nsb.1_Missense_Mutation_p.P1651A|GPR112_uc010nsc.1_Missense_Mutation_p.P1623A	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1856	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CTCTCCTCCTCCCACATCCCA	0.448													17	85					0	0	0	0	G	135431431	G	G	135431431	3	3	247	1	0	0	0	0	1	0	0	0	6667	855	30	2	5576	2	GPR112	23	135431431	Missense_Mutation	SNP	C	TCGA-CV-7407-01A-11D-2078-08	15922190	135431431	19839129	148	45434											
MCF2	4168	broad.mit.edu	37	chrX	138680607	138680607	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgattcgttgcactggtttGagtaaataggaatccagtct	10	14	11	6	1	1	2	0	2	1	0	3	3	2	3	1	2	1	4	1	2	4	5			TCGA-CV-7407-01A-11D-2078-08	TCGA-CV-7407-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	94631dc8-6dcb-49ed-bb68-e1a57a65f1cb	1ef9d6ea-cd89-4b1f-b699-623bc0293b99	g.chrX:138680607G>C	uc004fau.2	-	17	2181	c.1887C>G	c.(1885-1887)CTC>CTG	p.L629L	MCF2_uc004fav.2_Silent_p.L645L|MCF2_uc011mwl.1_Silent_p.L606L|MCF2_uc010nsh.1_Silent_p.L629L|MCF2_uc011mwm.1_Silent_p.L590L|MCF2_uc011mwn.1_Silent_p.L774L|MCF2_uc004faw.2_Silent_p.L689L|MCF2_uc011mwo.1_Silent_p.L705L	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	629	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					GCACTGGTTTGAGTAAATAGG	0.299													7	43					0	0	0	0	C	138680607	C	C	138680607	2	2	247	1	0	0	0	0	0	0	0	1	9431	1277	45	2		2	MCF2	23	138680607	Silent	SNP	G	TCGA-CV-7407-01A-11D-2078-08	3249176	138680607	16589953	149	45435											
GABRD	2563	broad.mit.edu	37	chr1	1961583	1961583	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acgaagaaggagggggcagcCcgctcaggaggccagggggg	10	1	21	9	2	1	1	1	0	0	1	1	4	1	3	2	8	1	2	2	8	2	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:1961583C>A	uc001aip.2	+	9	1316	c.1221C>A	c.(1219-1221)GCC>GCA	p.A407A		NM_000815	NP_000806	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	407	Cytoplasmic (Probable).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		AGGGGGCAGCCCGCTCAGGAG	0.697													78	57					1.17611e-34	1.65629e-34	1	0	A	1961583	A	A	1961583	2	1	248	1	0	0	0	0	0	0	0	1	6203	610	22	4		4	GABRD	1	1961583	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08		1961583	247289038	1	45436											
PRDM16	63976	broad.mit.edu	37	chr1	3348575	3348575	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgttagctttggagccgatGccgacttttgggaaggggct	6	12	15	8	2	0	0	0	0	0	0	0	4	0	2	2	4	3	3	2	4	2	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:3348575G>A	uc001akf.2	+	16	3647	c.3567G>A	c.(3565-3567)ATG>ATA	p.M1189I	PRDM16_uc001akc.2_Missense_Mutation_p.M1188I|PRDM16_uc001akd.2_Missense_Mutation_p.M1188I|PRDM16_uc001ake.2_Missense_Mutation_p.M1189I|PRDM16_uc009vlh.2_Missense_Mutation_p.M889I	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	1189	Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TGGAGCCGATGCCGACTTTTG	0.552			T	EVI1	MDS|AML								17	70					0	0	0	0	A	3348575	A	A	3348575	3	1	248	1	0	0	0	0	1	0	0	0	12519	1319	46	4	3629	4	PRDM16	1	3348575	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	1386992	3348575	245902046	2	45437											
PER3	8863	broad.mit.edu	37	chr1	7887874	7887874	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacgtgcccacaaactgagtAtgtaagtgatgctcattttc	11	12	8	10	1	1	2	1	2	0	0	2	2	1	2	1	0	3	3	1	0	3	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:7887874A>G	uc001aoo.2	+	17	3036	c.2861A>G	c.(2860-2862)TAT>TGT	p.Y954C	PER3_uc009vmg.1_Missense_Mutation_p.Y962C|PER3_uc009vmh.1_Missense_Mutation_p.Y955C|PER3_uc001aop.2_Missense_Mutation_p.Y962C|PER3_uc010nzw.1_Missense_Mutation_p.Y643C	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	954					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CAAACTGAGTATGTAAGTGAT	0.443													26	33					0	0	0	0	G	7887874	G	G	7887874	3	3	248	1	0	0	0	0	1	0	0	0	11785	463	16	5	2927	5	PER3	1	7887874	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	4539299	7887874	241362747	3	45438											
CSMD2	114784	broad.mit.edu	37	chr1	34006187	34006187	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaggtgaacaccgcgggcAgggagagctggtacccctcc	9	4	14	14	2	0	2	0	1	0	1	1	3	1	2	4	4	3	3	4	4	2	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:34006187A>T	uc001bxn.1	-	59	9166	c.9137T>A	c.(9136-9138)CTG>CAG	p.L3046Q	CSMD2_uc001bxm.1_Missense_Mutation_p.L3190Q	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3046	Sushi 23.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CACCGCGGGCAGGGAGAGCTG	0.582													23	108					0	0	0	0	T	34006187	T	T	34006187	3	4	248	1	0	0	0	0	1	0	0	0	3962	188	7	5	1370	5	CSMD2	1	34006187	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	26118313	34006187	215244434	4	45439											
KANK4	163782	broad.mit.edu	37	chr1	62740164	62740164	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaatccttctgcaggttcAaaggtgccatcacagacact	11	9	8	13	0	3	1	2	0	1	1	4	1	4	1	3	2	2	2	3	2	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:62740164A>C	uc001dah.3	-	3	989	c.612T>G	c.(610-612)TTT>TTG	p.F204L	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	204	Pro-rich.									ovary(3)|skin(2)|lung(1)	6						CTGCAGGTTCAAAGGTGCCAT	0.632													16	86					0	0	0	0	C	62740164	C	C	62740164	3	2	248	1	0	0	0	0	1	0	0	0	8018	127	5	5	2407	5	KANK4	1	62740164	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	28733977	62740164	186510457	5	45440											
LRRIQ3	127255	broad.mit.edu	37	chr1	74507574	74507574	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaactgatatcctaaaactGgtatccaatttttcatccac	15	13	3	10	0	1	1	1	1	0	0	4	1	4	1	3	1	2	1	3	1	7	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:74507574G>T	uc001dfy.3	-	7	1233	c.1041C>A	c.(1039-1041)ACC>ACA	p.T347T	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	347										ovary(2)	2						TCCTAAAACTGGTATCCAATT	0.308													10	18					0.000442599	0.000452404	1	0	T	74507574	T	T	74507574	2	4	248	1	0	0	0	0	0	0	0	1	9080	1335	47	4		4	LRRIQ3	1	74507574	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	11767410	74507574	174743047	6	45441											
SLC44A5	204962	broad.mit.edu	37	chr1	75707693	75707693	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agttgccacttacaaggtttGctgggaaaaatcgctgttgg	10	12	12	7	1	0	0	0	0	0	0	1	1	0	1	1	3	3	5	1	3	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:75707693G>T	uc001dgu.2	-	9	669	c.525C>A	c.(523-525)AGC>AGA	p.S175R	SLC44A5_uc001dgt.2_Missense_Mutation_p.S175R|SLC44A5_uc001dgs.2_Missense_Mutation_p.S133R|SLC44A5_uc001dgr.2_Missense_Mutation_p.S133R|SLC44A5_uc010oqz.1_Missense_Mutation_p.S214R|SLC44A5_uc010ora.1_Missense_Mutation_p.S169R|SLC44A5_uc010orb.1_Missense_Mutation_p.S45R	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	175	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TACAAGGTTTGCTGGGAAAAA	0.299													13	66					0.000308642	0.000318503	1	0	T	75707693	T	T	75707693	3	4	248	1	0	0	0	0	1	0	0	0	14703	1310	46	4	1809	4	SLC44A5	1	75707693	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	1200119	75707693	173542928	7	45442											
LPHN2	23266	broad.mit.edu	37	chr1	82302736	82302736	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taatcagcttcttaccaaatAcagaaggtaagatccagttt	15	12	6	8	0	2	2	1	0	1	2	3	2	3	2	2	1	3	3	2	1	6	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:82302736A>T	uc001dit.3	+	3	248	c.67A>T	c.(67-69)ACA>TCA	p.T23S	LPHN2_uc001dis.2_Missense_Mutation_p.T23S|LPHN2_uc001diu.2_Missense_Mutation_p.T23S|LPHN2_uc001div.2_Missense_Mutation_p.T23S|LPHN2_uc009wcd.2_Missense_Mutation_p.T23S	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	23					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CTTACCAAATACAGAAGGTAA	0.318													23	34					0	0	0	0	T	82302736	T	T	82302736	3	4	248	1	0	0	0	0	1	0	0	0	8966	391	14	5	69	5	LPHN2	1	82302736	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	6595043	82302736	166947885	8	45443											
ODF2L	57489	broad.mit.edu	37	chr1	86820356	86820356	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcaagctctttattttctgCgtccatctgttctaattttc	6	20	4	11	1	5	0	1	0	4	0	7	0	6	0	1	0	2	2	1	0	3	8			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:86820356C>A	uc001dll.1	-	16	1964	c.1624G>T	c.(1624-1626)GCA>TCA	p.A542S	ODF2L_uc001dlm.1_Missense_Mutation_p.A526S|ODF2L_uc001dln.2_Missense_Mutation_p.A513S|ODF2L_uc001dlo.2_Missense_Mutation_p.A382S|ODF2L_uc001dlp.2_Missense_Mutation_p.A489S|ODF2L_uc010osg.1_Missense_Mutation_p.A460S	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	542	Potential.					centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		TTATTTTCTGCGTCCATCTGT	0.313													12	19					9.31168e-06	9.86122e-06	1	0	A	86820356	A	A	86820356	3	1	248	1	0	0	0	0	1	0	0	0	10882	768	27	3	431	3	ODF2L	1	86820356	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	4517620	86820356	162430265	9	45444											
CCBL2	56267	broad.mit.edu	37	chr1	89418758	89418758	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacttacctgtaaaggagtTgcacaagtataaatcgtgtt	14	12	8	7	1	0	0	0	0	0	0	1	1	0	1	1	1	2	5	1	1	7	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:89418758T>A	uc001dmp.2	-	10	1319	c.942A>T	c.(940-942)GCA>GCT	p.A314A	CCBL2_uc001dmq.2_Silent_p.A280A|CCBL2_uc001dmr.2_Silent_p.A150A	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	314					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GTAAAGGAGTTGCACAAGTAT	0.338													18	20					0	0	0	0	A	89418758	A	A	89418758	2	1	248	1	0	0	0	0	0	0	0	1	2745	1799	63	5		5	CCBL2	1	89418758	Silent	SNP	T	TCGA-CV-7409-01A-31D-2229-08	2598402	89418758	159831863	10	45445											
LPPR4	9890	broad.mit.edu	37	chr1	99771793	99771793	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtacctcaaaatccagcctGgcgctgtccccggatgtaac	10	8	9	14	2	1	0	1	0	0	0	3	1	3	1	5	2	3	3	5	2	4	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:99771793G>A	uc001dse.2	+	7	1625	c.1519G>A	c.(1519-1521)GGC>AGC	p.G507S	LPPR4_uc010oue.1_Missense_Mutation_p.G449S	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	507							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AATCCAGCCTGGCGCTGTCCC	0.562													130	294					0	0	0	0	A	99771793	A	A	99771793	3	1	248	1	0	0	0	0	1	0	0	0	8977	1348	47	4	1545	4	LPPR4	1	99771793	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	10353035	99771793	149478828	11	45446											
AMPD2	271	broad.mit.edu	37	chr1	110172028	110172028	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagagccccctgcctgaggCgtgggtggaggaggacaacc	8	4	18	11	1	0	2	0	1	0	1	0	6	0	5	4	6	3	0	4	6	1	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:110172028C>A	uc009wfh.1	+	15	2482	c.1940C>A	c.(1939-1941)GCG>GAG	p.A647E	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Missense_Mutation_p.A566E|AMPD2_uc001dyc.1_Missense_Mutation_p.A647E|AMPD2_uc010ovr.1_Missense_Mutation_p.A572E|AMPD2_uc001dyd.1_Missense_Mutation_p.A528E|AMPD2_uc001dye.1_5'UTR	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	647					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		CTGCCTGAGGCGTGGGTGGAG	0.562													92	326					2.94851e-48	4.36866e-48	1	0	A	110172028	A	A	110172028	3	1	248	1	0	0	0	0	1	0	0	0	586	768	27	3	2035	3	AMPD2	1	110172028	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	10400235	110172028	139078593	12	45447											
SEMA6C	10500	broad.mit.edu	37	chr1	151105901	151105901	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaggccagagactgaggCgcccagggcaaaagctgcgg	11	2	17	11	2	0	2	0	1	0	1	0	4	0	3	2	5	2	2	2	5	2	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:151105901C>A	uc001ewu.2	-	19	2152	c.1852G>T	c.(1852-1854)GCC>TCC	p.A618S	SEMA6C_uc001ewv.2_Missense_Mutation_p.A650S|SEMA6C_uc001eww.2_Missense_Mutation_p.A610S|SEMA6C_uc010pcq.1_Intron	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	618	Helical; (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGACTGAGGCGCCCAGGGCA	0.726													5	7					3.59834e-05	3.76137e-05	1	0	A	151105901	A	A	151105901	3	1	248	1	0	0	0	0	1	0	0	0	14106	768	27	3	944	3	SEMA6C	1	151105901	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	40933873	151105901	98144720	13	45448											
PIP5K1A	8394	broad.mit.edu	37	chr1	151210743	151210743	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattctacagtcttacaggTgaggagcatatggatcccaa	13	10	9	9	0	2	1	0	1	2	0	3	3	3	3	1	3	3	1	1	3	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:151210743T>C	uc001exj.2	+	10	1681	c.1229_splice	c.e10+2	p.R410_splice	PIP5K1A_uc001exi.2_Splice_Site_p.R397_splice|PIP5K1A_uc010pcu.1_Intron|PIP5K1A_uc001exk.2_Splice_Site_p.R397_splice|PIP5K1A_uc010pcv.1_Splice_Site_p.R167_splice	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type						phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTCTTACAGGTGAGGAGCATA	0.433													24	50					0	0	0	0	C	151210743	C	C	151210743	5	2	248	1	0	0	0	0	0	0	1	0	11994	1710	59	5	1269	5	PIP5K1A	1	151210743	Splice_Site	SNP	T	TCGA-CV-7409-01A-31D-2229-08	104842	151210743	98039878	14	45449											
GATAD2B	57459	broad.mit.edu	37	chr1	153789912	153789912	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtacaaggccaggcttaggcGggccccgctgaccctgtagc	7	6	14	14	2	0	1	0	1	0	0	0	1	0	1	4	4	2	4	4	4	4	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:153789912G>A	uc001fdb.3	-	6	1080	c.836C>T	c.(835-837)CCG>CTG	p.P279L		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	279						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AGGCTTAGGCGGGCCCCGCTG	0.527													46	99					0	0	0	0	A	153789912	A	A	153789912	3	1	248	1	0	0	0	0	1	0	0	0	6296	1116	39	1	969	1	GATAD2B	1	153789912	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	2579169	153789912	95460709	15	45450											
COPA	1314	broad.mit.edu	37	chr1	160283779	160283779	+	Splice_Site	DEL	C	-	-																															caacactgaggactaccttaCcgcttagacatatcccagac																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:160283779delC	uc009wti.2	-	9	1236	c.842_splice	c.e9+1	p.R281_splice	COPA_uc001fvv.3_Splice_Site_p.R281_splice|COPA_uc009wtj.1_Splice_Site_p.R227_splice	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform						COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GACTACCTTACCGCTTAGACA	0.408													---	---	---								-	160283779	-	-	160283779	8	5	248	1	0	1	0	1	0	0	1	0	3742	521	18	0	2958	0	COPA	1	160283779	Splice_Site	DEL	C	TCGA-CV-7409-01A-31D-2229-08	6493867	160283779	88966842	16	45451											
NUF2	83540	broad.mit.edu	37	chr1	163306634	163306634	+	Frame_Shift_Del	DEL	A	-	-																															gtatatggaatttctttggcAatatgtaagatttaaatatg																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:163306634delA	uc001gcq.1	+	6	731	c.431delA	c.(430-432)CAAfs	p.Q144fs	NUF2_uc001gcp.2_Frame_Shift_Del_p.Q144fs|NUF2_uc001gcr.1_Frame_Shift_Del_p.Q144fs|NUF2_uc009wvc.1_Frame_Shift_Del_p.Q144fs	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	144	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					TTTCTTTGGCAATATGTAAGA	0.318													---	---	---								-	163306634	-	-	163306634	7	5	248	1	0	1	0	1	0	0	0	0	10801	130	5	0	449	0	NUF2	1	163306634	Frame_Shift_Del	DEL	A	TCGA-CV-7409-01A-31D-2229-08	3022855	163306634	85943987	17	45452											
LMX1A	4009	broad.mit.edu	37	chr1	165322430	165322430	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagaagctgtcgttgagcCgcagcagaaacctgtccaag	11	6	12	12	2	0	3	0	1	0	2	2	3	1	3	4	0	4	4	4	0	3	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:165322430C>A	uc001gcy.1	-	2	367	c.146G>T	c.(145-147)CGG>CTG	p.R49L	LMX1A_uc001gcz.1_Missense_Mutation_p.R49L	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	49	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					GTCGTTGAGCCGCAGCAGAAA	0.612													16	36					3.32936e-07	3.62082e-07	1	0	A	165322430	A	A	165322430	3	1	248	1	0	0	0	0	1	0	0	0	8903	652	23	3	1030	3	LMX1A	1	165322430	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	2015796	165322430	83928191	18	45453											
CFH	3075	broad.mit.edu	37	chr1	196648897	196648897	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgctgtatgcactgaatctgGatggcgtccgttgccttcat	6	14	11	10	2	2	1	1	1	1	0	3	2	3	2	2	2	3	4	2	2	2	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:196648897G>T	uc001gtj.3	+	6	1004	c.764G>T	c.(763-765)GGA>GTA	p.G255V	CFH_uc001gti.3_Missense_Mutation_p.G255V|CFH_uc009wyw.2_Missense_Mutation_p.G255V|CFH_uc009wyx.2_Missense_Mutation_p.G191V	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	255	Sushi 4.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						ACTGAATCTGGATGGCGTCCG	0.294													14	56					0.000422831	0.000434951	1	0	T	196648897	T	T	196648897	3	4	248	1	0	0	0	0	1	0	0	0	3298	1174	41	2	786	2	CFH	1	196648897	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	31326467	196648897	52601724	19	45454											
LMOD1	25802	broad.mit.edu	37	chr1	201869086	201869087	+	Frame_Shift_Ins	INS	-	A	A																															gttgaactccagagcctcagINStaaaccggaccaagatctca																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:201869086_201869087insA	uc001gxb.2	-	2	1302_1303	c.1054_1055insT	c.(1054-1056)ACTfs	p.T352fs	LMOD1_uc010ppu.1_Frame_Shift_Ins_p.T301fs	NM_012134	NP_036266	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	352					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			ovary(1)|pancreas(1)|skin(1)	3						CAGAGCCTCAGTAAACCGGACC	0.525													---	---	---								A	201869087	A	A	201869086	7	5	248	1	0	1	1	0	0	0	0	0	8898	1029	36	0	755	0	LMOD1	1	201869086	Frame_Shift_Ins	INS	-	TCGA-CV-7409-01A-31D-2229-08	5220189	201869086	47381535	20	45455											
INTS7	25896	broad.mit.edu	37	chr1	212154469	212154478	+	Frame_Shift_Del	DEL	TGACTACAAA	-	-																															gagcacctggactatcatctTgactacaaagtaccagtagg																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:212154469_212154478delTGACTACAAA	uc001hiw.1	-	10	1292_1301	c.1187_1196delTTTGTAGTCA	c.(1186-1197)CTTTGTAGTCAAfs	p.L396fs	INTS7_uc009xdb.1_Frame_Shift_Del_p.L396fs|INTS7_uc001hix.1_Frame_Shift_Del_p.L272fs|INTS7_uc001hiy.1_Frame_Shift_Del_p.L396fs|INTS7_uc010pta.1_Frame_Shift_Del_p.L347fs	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	396_399					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		ACTATCATCTTGACTACAAAGTACCAGTAG	0.367													---	---	---								-	212154478	-	-	212154469	7	5	248	1	0	1	0	1	0	0	0	0	7822	1812	63	0	1736	0	INTS7	1	212154469	Frame_Shift_Del	DEL	TGACTACAAA	TCGA-CV-7409-01A-31D-2229-08	10285383	212154469	37096152	21	45456											
DISP1	84976	broad.mit.edu	37	chr1	223165426	223165426	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttgactggaacttccacaAggacagctttttctgcgacg	10	11	10	10	2	1	1	0	1	1	0	2	4	2	3	1	2	3	2	1	2	2	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:223165426A>G	uc001hnu.1	+	6	1010	c.863A>G	c.(862-864)AAG>AGG	p.K288R		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	288					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AACTTCCACAAGGACAGCTTT	0.403													18	48					0	0	0	0	G	223165426	G	G	223165426	3	3	248	1	0	0	0	0	1	0	0	0	4561	72	3	5	881	5	DISP1	1	223165426	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	11010957	223165426	26085195	22	45457											
KIAA1383	54627	broad.mit.edu	37	chr1	232941067	232941067	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagacaccgcccgagacccGctggagcgcttccgcaaatc	9	4	11	17	5	0	2	0	0	0	2	2	4	1	3	4	1	1	4	4	1	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:232941067G>A	uc001hvh.2	+	1	430	c.298G>A	c.(298-300)GCT>ACT	p.A100T		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	Error:Variant_position_missing_in_Q9P2G4_after_alignment										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				CCCGAGACCCGCTGGAGCGCT	0.562													27	68					0	0	0	0	A	232941067	A	A	232941067	3	1	248	1	0	0	0	0	1	0	0	0	8267	1087	38	1	300	1	KIAA1383	1	232941067	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	9775641	232941067	16309554	23	45458											
C1orf31	388753	broad.mit.edu	37	chr1	234509385	234509385	+	5'Flank	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgtgacagtttcctcccGtcgacatcgaaaggaagccg	9	8	11	13	5	0	1	0	1	0	0	4	4	2	2	3	1	2	1	3	1	2	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:234509385G>T	uc001hwc.2	+						C1orf31_uc001hwb.2_5'UTR	NM_001012985	NP_001013003	Q5JTJ3	CA031_HUMAN	hypothetical protein LOC388753							mitochondrion	cytochrome-c oxidase activity				0	Ovarian(103;0.0339)	all_cancers(173;0.241)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			GTTTCCTCCCGTCGACATCGA	0.687													83	194					1.76565e-42	2.56895e-42	1	0	T	234509385	T	T	234509385	1	4	248	0	1	0	0	0	0	0	0	0	2047	1160	40	3		3	C1orf31	1	234509385	5'Flank	SNP	G	TCGA-CV-7409-01A-31D-2229-08	1568318	234509385	14741236	24	45459											
RYR2	6262	broad.mit.edu	37	chr1	237494248	237494248	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgtccgggcgctgcaggAgatgctggctaacaccgtgg	6	8	15	12	3	1	1	0	0	1	1	2	2	2	1	2	4	3	4	2	4	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:237494248A>C	uc001hyl.1	+	3	359	c.239A>C	c.(238-240)GAG>GCG	p.E80A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	80	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCGCTGCAGGAGATGCTGGCT	0.498													41	104					0	0	0	0	C	237494248	C	C	237494248	3	2	248	1	0	0	0	0	1	0	0	0	13834	304	11	5	249	5	RYR2	1	237494248	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	2984863	237494248	11756373	25	45460											
RYR2	6262	broad.mit.edu	37	chr1	237806679	237806679	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aattaggtccattttgagatCcctcattcccctgggagatt	9	14	8	10	0	1	2	1	1	0	2	4	4	4	2	4	2	0	0	4	2	2	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:237806679C>A	uc001hyl.1	+	48	7394	c.7274C>A	c.(7273-7275)TCC>TAC	p.S2425Y		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2425	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATTTTGAGATCCCTCATTCCC	0.423													42	111					9.84934e-19	1.23787e-18	1	0	A	237806679	A	A	237806679	3	1	248	1	0	0	0	0	1	0	0	0	13834	855	30	2	7464	2	RYR2	1	237806679	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	312431	237806679	11443942	26	45461											
TRIM58	25893	broad.mit.edu	37	chr1	248020819	248020819	+	Frame_Shift_Del	DEL	C	-	-																															ggctggggttgggcgcggggCccggggcgcggcgatgcgcg																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr1:248020819delC	uc001ido.2	+	1	319	c.271delC	c.(271-273)CCCfs	p.P91fs		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	91	B box-type.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			gggcgcggggcccggggcgcg	0.667													---	---	---								-	248020819	-	-	248020819	7	5	248	1	0	1	0	1	0	0	0	0	16598	739	26	0	273	0	TRIM58	1	248020819	Frame_Shift_Del	DEL	C	TCGA-CV-7409-01A-31D-2229-08	10214140	248020819	1229802	27	45462											
TPO	7173	broad.mit.edu	37	chr2	1480943	1480943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgcggcaccggggaccaagGcgcgctctttgggaacctgt	6	7	15	13	4	1	0	0	0	1	0	1	2	1	2	3	5	2	2	3	5	2	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:1480943G>A	uc002qww.2	+	8	996	c.905G>A	c.(904-906)GGC>GAC	p.G302D	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.G302D|TPO_uc002qwr.2_Missense_Mutation_p.G302D|TPO_uc002qwx.2_Missense_Mutation_p.G302D|TPO_uc010yio.1_Intron|TPO_uc010yip.1_Missense_Mutation_p.G302D	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	302	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGGACCAAGGCGCGCTCTTT	0.716													11	29					0	0	0	0	A	1480943	A	A	1480943	3	1	248	1	0	0	0	0	1	0	0	0	16477	1203	42	4	931	4	TPO	2	1480943	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08		1480943	241718430	28	45463											
LRRTM4	80059	broad.mit.edu	37	chr2	77746577	77746577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagcttattgtaggagaGgtccagattgcggagattgg	10	11	15	5	1	0	4	0	1	0	3	1	6	1	4	1	4	2	2	1	4	3	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:77746577G>A	uc002snr.2	-	3	833	c.418C>T	c.(418-420)CTC>TTC	p.L140F	LRRTM4_uc002snq.2_Missense_Mutation_p.L140F|LRRTM4_uc002sns.2_Missense_Mutation_p.L140F|LRRTM4_uc002snt.2_Missense_Mutation_p.L141F	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	140	LRR 4.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		TTGTAGGAGAGGTCCAGATTG	0.393													16	35					0	0	0	0	A	77746577	A	A	77746577	3	1	248	1	0	0	0	0	1	0	0	0	9092	1000	35	4	1368	4	LRRTM4	2	77746577	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	76265634	77746577	165452796	29	45464											
USP39	10713	broad.mit.edu	37	chr2	85868160	85868160	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcttaccaagttgcctccatAtctaatcttttgtatcaaga	11	15	5	10	0	3	1	1	0	2	1	4	1	4	1	3	0	2	3	3	0	6	7			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:85868160A>G	uc002sqe.2	+	10	1382	c.1346A>G	c.(1345-1347)TAT>TGT	p.Y449C	USP39_uc002sqb.2_Missense_Mutation_p.Y180C|USP39_uc010ysu.1_Missense_Mutation_p.Y371C|USP39_uc010ysv.1_Missense_Mutation_p.Y346C|USP39_uc010fgn.1_Missense_Mutation_p.Y449C|USP39_uc002sqf.2_Missense_Mutation_p.Y449C|USP39_uc002sqg.2_Missense_Mutation_p.Y449C|USP39_uc010fgo.2_Missense_Mutation_p.Y449C	NM_006590	NP_006581	Q53GS9	SNUT2_HUMAN	ubiquitin specific protease 39	449					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)	1						TTGCCTCCATATCTAATCTTT	0.358													21	35					0	0	0	0	G	85868160	G	G	85868160	3	3	248	1	0	0	0	0	1	0	0	0	17138	449	16	5	1384	5	USP39	2	85868160	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	8121583	85868160	157331213	30	45465											
NPAS2	4862	broad.mit.edu	37	chr2	101591346	101591346	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccttaataccagtcattcgCcatcggcgtcctcaagaagt	10	10	8	13	3	2	1	2	0	0	1	5	1	3	1	4	1	1	0	4	1	4	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:101591346C>T	uc002tap.1	+	13	1508	c.1222C>T	c.(1222-1224)CCA>TCA	p.P408S	NPAS2_uc010yvt.1_Missense_Mutation_p.P473S|NPAS2_uc010fit.1_5'UTR	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	408					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						CAGTCATTCGCCATCGGCGTC	0.547													12	47					0	0	0	0	T	101591346	T	T	101591346	3	4	248	1	0	0	0	0	1	0	0	0	10617	739	26	4	1268	4	NPAS2	2	101591346	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	15723186	101591346	141608027	31	45466											
CNTNAP5	129684	broad.mit.edu	37	chr2	125192073	125192073	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttcccagaatcagatgttgCtgactttgatggccgaagct	9	12	11	9	1	1	4	1	2	0	2	2	5	2	4	2	1	2	4	2	1	2	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:125192073C>T	uc002tno.2	+	5	906	c.542C>T	c.(541-543)GCT>GTT	p.A181V	CNTNAP5_uc010flu.2_Missense_Mutation_p.A181V	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	181	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCAGATGTTGCTGACTTTGAT	0.418													22	75					0	0	0	0	T	125192073	T	T	125192073	3	4	248	1	0	0	0	0	1	0	0	0	3665	797	28	4	560	4	CNTNAP5	2	125192073	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	23600727	125192073	118007300	32	45467											
CNTNAP5	129684	broad.mit.edu	37	chr2	125281896	125281896	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggcagcaacttgaatgaTggcctgtggcactcggttag	9	9	14	9	1	0	2	0	2	0	0	1	2	0	2	1	4	2	5	1	4	3	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:125281896T>A	uc002tno.2	+	9	1705	c.1341T>A	c.(1339-1341)GAT>GAA	p.D447E	CNTNAP5_uc010flu.2_Missense_Mutation_p.D448E	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	447	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		ACTTGAATGATGGCCTGTGGC	0.557													29	52					0	0	0	0	A	125281896	A	A	125281896	3	1	248	1	0	0	0	0	1	0	0	0	3665	1461	51	5	1375	5	CNTNAP5	2	125281896	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	89823	125281896	117917477	33	45468											
LRP1B	53353	broad.mit.edu	37	chr2	141460021	141460021	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtcgatggagatgccattcGgccatgctattcccatgctt	8	12	10	11	2	0	1	0	0	0	1	3	3	1	1	3	2	3	2	3	2	1	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:141460021G>C	uc002tvj.1	-	38	7097	c.6125C>G	c.(6124-6126)CCG>CGG	p.P2042R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2042	Extracellular (Potential).|LDL-receptor class B 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GATGCCATTCGGCCATGCTAT	0.428										TSP Lung(27;0.18)			21	62					0	0	0	0	C	141460021	C	C	141460021	3	2	248	1	0	0	0	0	1	0	0	0	9005	1116	39	3	7890	3	LRP1B	2	141460021	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	16178125	141460021	101739352	34	45469											
NEB	4703	broad.mit.edu	37	chr2	152427093	152427094	+	Frame_Shift_Ins	INS	-	C	C																															acagcccgccttcatttcatINScccagccctcacggtaaagt																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:152427093_152427094insC	uc010fnx.2	-	80	12123_12124	c.11932_11933insG	c.(11932-11934)GATfs	p.D3978fs	NEB_uc002txr.2_Frame_Shift_Ins_p.D401fs	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3978	Nebulin 108.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTTCATTTCATCCCAGCCCTCA	0.48													---	---	---								C	152427094	C	C	152427093	7	5	248	1	0	1	1	0	0	0	0	0	10356	1435	50	0	8950	0	NEB	2	152427093	Frame_Shift_Ins	INS	-	TCGA-CV-7409-01A-31D-2229-08	10967072	152427093	90772280	35	45470											
ACVR1	90	broad.mit.edu	37	chr2	158595049	158595049	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgggtcattgggaaccacaTcgtagaacggtggcttgtaa	10	11	13	7	2	1	1	1	0	0	1	2	2	1	2	1	4	2	3	1	4	4	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:158595049T>A	uc002tzm.3	-	11	1637	c.1298A>T	c.(1297-1299)GAT>GTT	p.D433V	ACVR1_uc002tzn.3_Missense_Mutation_p.D433V|ACVR1_uc010fog.2_Missense_Mutation_p.D433V	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	433	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	GGGAACCACATCGTAGAACGG	0.463													27	112					0	0	0	0	A	158595049	A	A	158595049	3	1	248	1	0	0	0	0	1	0	0	0	220	1435	50	5	239	5	ACVR1	2	158595049	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	6167956	158595049	84604324	36	45471											
TTN	7273	broad.mit.edu	37	chr2	179436458	179436459	+	Missense_Mutation	DNP	GG	AT	AT																															gtcaagaacgataacattaaGggtttcaatagcttcaccag																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:179436458_179436459GG>AT	uc010zfg.1	-	275	66920_66921	c.66696_66697CC>AT	c.(66694-66699)ACCCTT>ACATTT	p.L22233F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L15928F|TTN_uc010zfi.1_Missense_Mutation_p.L15861F|TTN_uc010zfj.1_Missense_Mutation_p.L15736F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23160							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAACATTAAGGGTTTCAATAG	0.436													41	64					0	0	0	0	AT	179436459	AT	AT	179436458	3	1	248	1	0	0	0	0	1	0	0	0	16803	1000	35	4	33726	4	TTN	2	179436458	Missense_Mutation	DNP	GG	TCGA-CV-7409-01A-31D-2229-08	20841409	179436458	63762915	37	45472											
TTN	7273	broad.mit.edu	37	chr2	179463659	179463659	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttccatctctttgaagtGgtgtctttcatttccagcca	6	17	6	12	0	4	1	1	1	3	0	7	1	6	1	3	1	1	0	3	1	1	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:179463659G>C	uc010zfg.1	-	240	49298	c.49074C>G	c.(49072-49074)ACC>ACG	p.T16358T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T10053T|TTN_uc010zfi.1_Silent_p.T9986T|TTN_uc010zfj.1_Silent_p.T9861T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17285							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTGAAGTGGTGTCTTTCA	0.453													12	39					0	0	0	0	C	179463659	C	C	179463659	2	2	248	1	0	0	0	0	0	0	0	1	16803	1335	47	4		4	TTN	2	179463659	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	27201	179463659	63735714	38	45473											
TTN	7273	broad.mit.edu	37	chr2	179472023	179472023	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttacaacaggttttaagtcaAgaactggaccagggacatct	14	10	9	8	0	2	1	1	0	1	1	2	3	2	3	1	3	3	1	1	3	5	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:179472023A>G	uc010zfg.1	-	227	45826	c.45602T>C	c.(45601-45603)CTT>CCT	p.L15201P	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L8896P|TTN_uc010zfi.1_Missense_Mutation_p.L8829P|TTN_uc010zfj.1_Missense_Mutation_p.L8704P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16128							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTAAGTCAAGAACTGGACC	0.358													9	30					0	0	0	0	G	179472023	G	G	179472023	3	3	248	1	0	0	0	0	1	0	0	0	16803	72	3	5	54727	5	TTN	2	179472023	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	8364	179472023	63727350	39	45474											
DNAH7	56171	broad.mit.edu	37	chr2	196750877	196750877	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaccttacctcaagcaaagaGtaagtttctcgatcatttct	12	13	6	10	1	4	1	2	0	2	1	5	3	4	1	2	0	2	3	2	0	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:196750877G>A	uc002utj.3	-	34	5627	c.5526C>T	c.(5524-5526)TAC>TAT	p.Y1842Y		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1842					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CAAGCAAAGAGTAAGTTTCTC	0.383													18	94					0	0	0	0	A	196750877	A	A	196750877	2	1	248	1	0	0	0	0	0	0	0	1	4628	1024	36	4		4	DNAH7	2	196750877	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	17278854	196750877	46448496	40	45475											
SATB2	23314	broad.mit.edu	37	chr2	200193507	200193507	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctccgctccctctcatcctGgtagatgcgatctcgctcca	5	11	8	17	3	2	1	1	0	2	1	8	2	6	1	4	1	1	4	4	1	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:200193507G>A	uc002uuy.1	-	8	2117	c.1300C>T	c.(1300-1302)CAG>TAG	p.Q434*	SATB2_uc010fsq.1_Nonsense_Mutation_p.Q316*|SATB2_uc002uuz.1_Nonsense_Mutation_p.Q434*|SATB2_uc002uva.1_Nonsense_Mutation_p.Q434*	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	434	CUT 1.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCTCATCCTGGTAGATGCGA	0.557													83	98					0	0	0	0	A	200193507	A	A	200193507	4	1	248	1	0	0	0	0	0	1	0	0	13919	1357	47	4	917	4	SATB2	2	200193507	Nonsense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	3442630	200193507	43005866	41	45476											
TTLL4	9654	broad.mit.edu	37	chr2	219602784	219602784	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctataggcaaaaaccgtacCagcaactggagtctttctgc	12	9	9	11	1	2	0	0	0	2	0	2	1	2	1	2	2	5	4	2	2	6	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:219602784C>T	uc002viy.2	+	3	755	c.385C>T	c.(385-387)CAG>TAG	p.Q129*	TTLL4_uc010zkl.1_5'UTR|TTLL4_uc010fvx.2_Nonsense_Mutation_p.Q129*	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	129					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		AAAACCGTACCAGCAACTGGA	0.532													44	46					0	0	0	0	T	219602784	T	T	219602784	4	4	248	1	0	0	0	0	0	1	0	0	16797	595	21	4	387	4	TTLL4	2	219602784	Nonsense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	19409277	219602784	23596589	42	45477											
SPHKAP	80309	broad.mit.edu	37	chr2	228996727	228996728	+	Missense_Mutation	DNP	CC	AG	AG																															ctgtgatggagttccccgggCcgcttcctgagctgccacag																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:228996727_228996728CC>AG	uc002vpq.2	-	2	153_154	c.106_107GG>CT	c.(106-108)GGC>CTC	p.G36L	SPHKAP_uc002vpp.2_Missense_Mutation_p.G36L|SPHKAP_uc010zlx.1_Missense_Mutation_p.G36L	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	36						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GTTCCCCGGGCCGCTTCCTGAG	0.46													37	54					0	0	0	0	AG	228996728	AG	AG	228996727	3	1	248	1	0	0	0	0	1	0	0	0	15114	739	26	4	5039	4	SPHKAP	2	228996727	Missense_Mutation	DNP	CC	TCGA-CV-7409-01A-31D-2229-08	9393943	228996727	14202646	43	45478											
CHRNG	1146	broad.mit.edu	37	chr2	233407649	233407649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgctcctggacccagcggCgccagcccaggaagcaggcc	8	3	14	16	2	0	0	0	0	0	0	1	3	1	2	5	4	4	2	5	4	1	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:233407649C>T	uc002vsx.1	+	7	683	c.662C>T	c.(661-663)GCG>GTG	p.A221V	CHRNG_uc010fye.1_Missense_Mutation_p.A169V	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	221	Extracellular (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		GACCCAGCGGCGCCAGCCCAG	0.632													11	42					0	0	0	0	T	233407649	T	T	233407649	3	4	248	1	0	0	0	0	1	0	0	0	3411	768	27	1	688	1	CHRNG	2	233407649	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	4410922	233407649	9791724	44	45479											
INPP5D	3635	broad.mit.edu	37	chr2	234072460	234072460	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccatgacatttacgtgatcGgcacccaagaggaccccctg	10	7	9	15	2	0	3	0	2	0	1	1	4	0	4	4	2	1	1	4	2	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:234072460G>A	uc010zmo.1	+	11	1501	c.1348G>A	c.(1348-1350)GGC>AGC	p.G450S	INPP5D_uc010zmp.1_Missense_Mutation_p.G449S	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	450					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TTACGTGATCGGCACCCAAGA	0.552													78	70					0	0	0	0	A	234072460	A	A	234072460	3	1	248	1	0	0	0	0	1	0	0	0	7795	1116	39	1	902	1	INPP5D	2	234072460	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	664811	234072460	9126913	45	45480											
COL6A3	1293	broad.mit.edu	37	chr2	238275606	238275606	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaggcaatctgagggacccGctggtccaggcggctgcctg	8	6	15	12	2	1	1	0	1	1	0	2	2	2	2	3	5	1	3	3	5	2	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr2:238275606G>T	uc002vwl.2	-	11	5509	c.5224C>A	c.(5224-5226)CGG>AGG	p.R1742R	COL6A3_uc002vwo.2_Silent_p.R1536R|COL6A3_uc010znj.1_Silent_p.R1135R	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1742	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGAGGGACCCGCTGGTCCAGG	0.592													20	26					1.50039e-11	1.74326e-11	1	0	T	238275606	T	T	238275606	2	4	248	1	0	0	0	0	0	0	0	1	3716	1086	38	3		3	COL6A3	2	238275606	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	4203146	238275606	4923767	46	45481											
SETD5	55209	broad.mit.edu	37	chr3	9512328	9512328	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatggacatcagaccctcgtGagaaactcagaccaggcatt	13	7	10	11	1	2	3	2	1	0	3	3	6	2	4	2	2	1	1	2	2	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:9512328G>A	uc003brt.2	+	19	3345	c.2910G>A	c.(2908-2910)GTG>GTA	p.V970V	SETD5_uc003bru.2_Silent_p.V872V|SETD5_uc003brv.2_Silent_p.V859V|SETD5_uc010hck.2_Silent_p.V452V|SETD5_uc003brx.2_Silent_p.V639V	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	970										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGACCCTCGTGAGAAACTCAG	0.517													50	96					0	0	0	0	A	9512328	A	A	9512328	2	1	248	1	0	0	0	0	0	0	0	1	14199	1277	45	2		2	SETD5	3	9512328	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08		9512328	188510102	47	45482											
STT3B	201595	broad.mit.edu	37	chr3	31658535	31658535	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcactagctgcaggtgctgTgttccttagtgtcatctatt	7	16	9	9	0	3	0	2	0	1	0	4	0	4	0	1	1	3	4	1	1	3	5	rs35863057		TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:31658535T>A	uc011axe.1	+	7	1091	c.1091T>A	c.(1090-1092)GTG>GAG	p.V364E	STT3B_uc010hft.1_Missense_Mutation_p.V364E|STT3B_uc003cer.1_Missense_Mutation_p.V364E|STT3B_uc003cet.2_Missense_Mutation_p.V115E	NM_178862	NP_849193	Q8TCJ2	STT3B_HUMAN	source of immunodominant MHC-associated	364	Helical; (Potential).				protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0						GCAGGTGCTGTGTTCCTTAGT	0.383													51	44					0	0	0	0	A	31658535	A	A	31658535	3	1	248	1	0	0	0	0	1	0	0	0	15400	1696	59	5	1117	5	STT3B	3	31658535	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	22146207	31658535	166363895	48	45483											
GLB1	2720	broad.mit.edu	37	chr3	33099621	33099621	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgtagaggccctgcagggcCccacatttcaggaatgtttt	8	11	12	10	0	1	1	1	0	0	1	1	2	1	2	3	3	1	3	3	3	2	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:33099621C>A	uc003cfi.1	-	6	810	c.693G>T	c.(691-693)GGG>GGT	p.G231G	GLB1_uc003cfh.1_Silent_p.G201G|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Silent_p.G279G	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	231					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				CCTGCAGGGCCCCACATTTCA	0.488													19	16					1.36565e-18	1.7097e-18	1	0	A	33099621	A	A	33099621	2	1	248	1	0	0	0	0	0	0	0	1	6464	610	22	4		4	GLB1	3	33099621	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	1441086	33099621	164922809	49	45484											
DCLK3	85443	broad.mit.edu	37	chr3	36779293	36779293	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcctcgggtcctgcggagCttctcaaagcccgcctggtg	4	10	12	15	3	2	0	1	0	2	0	6	1	3	1	4	3	3	1	4	3	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:36779293C>G	uc003cgi.2	-	2	1349	c.858G>C	c.(856-858)AAG>AAC	p.K286N		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	286						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						TCCTGCGGAGCTTCTCAAAGC	0.572													51	66					0	0	0	0	G	36779293	G	G	36779293	3	3	248	1	0	0	0	0	1	0	0	0	4310	796	28	4	1104	4	DCLK3	3	36779293	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	3679672	36779293	161243137	50	45485											
DOCK3	1795	broad.mit.edu	37	chr3	51394511	51394511	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggcaacattaacctgctaaGcatgtgcctgaatggtgtca	11	11	10	9	0	1	1	1	1	0	0	1	1	1	1	2	2	5	3	2	2	4	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:51394511G>T	uc011bds.1	+	44	4645	c.4622G>T	c.(4621-4623)AGC>ATC	p.S1541I		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1541	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AACCTGCTAAGCATGTGCCTG	0.517													27	97					1.08312e-15	1.32018e-15	1	0	T	51394511	T	T	51394511	3	4	248	1	0	0	0	0	1	0	0	0	4710	971	34	4	4796	4	DOCK3	3	51394511	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	14615218	51394511	146627919	51	45486											
NISCH	11188	broad.mit.edu	37	chr3	52504899	52504899	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaatggcatcaccgcggcaCtggctgaagagctctttgag	10	9	12	10	2	2	3	1	2	1	1	2	3	2	3	1	3	1	4	1	3	3	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:52504899C>G	uc011beg.1	+	5	457	c.385C>G	c.(385-387)CTG>GTG	p.L129V	NISCH_uc003ded.3_Missense_Mutation_p.L129V|NISCH_uc003dec.1_Missense_Mutation_p.L129V	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	129	Necessary for homooligomerization and targeting to endosomes.|Necessary for binding to phosphoinositide-3-P; not sufficient for targeting to endosomes.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CACCGCGGCACTGGCTGAAGA	0.507													59	87					0	0	0	0	G	52504899	G	G	52504899	3	3	248	1	0	0	0	0	1	0	0	0	10486	564	20	4	399	4	NISCH	3	52504899	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	1110388	52504899	145517531	52	45487											
KBTBD8	84541	broad.mit.edu	37	chr3	67058734	67058734	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgtatgagaccccagatcgGctctgggaccttggccggca	7	8	14	12	2	1	2	0	1	1	2	2	4	1	3	4	4	0	3	4	4	1	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:67058734G>T	uc003dmy.2	+	4	1784	c.1731G>T	c.(1729-1731)CGG>CGT	p.R577R	KBTBD8_uc011bfv.1_Silent_p.R135R	NM_032505	NP_115894	Q8NFY9	KBTB8_HUMAN	T-cell activation kelch repeat protein	577	Kelch 5.									ovary(2)|large_intestine(1)|breast(1)	4		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		CCCCAGATCGGCTCTGGGACC	0.448													32	44					6.02846e-25	7.82004e-25	1	0	T	67058734	T	T	67058734	2	4	248	1	0	0	0	0	0	0	0	1	8038	1190	42	4		4	KBTBD8	3	67058734	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	14553835	67058734	130963696	53	45488											
TMF1	7110	broad.mit.edu	37	chr3	69096945	69096945	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaaatcatctaaacgattaTattcaggacaagcagatgca	17	9	8	7	1	3	1	2	0	1	1	3	4	3	3	0	2	3	2	0	2	6	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:69096945T>C	uc003dnn.2	-	2	1158	c.911A>G	c.(910-912)TAT>TGT	p.Y304C	TMF1_uc011bfx.1_Missense_Mutation_p.Y304C	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	304					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		TAAACGATTATATTCAGGACA	0.398													9	33					0	0	0	0	C	69096945	C	C	69096945	3	2	248	1	0	0	0	0	1	0	0	0	16294	1406	49	5	2434	5	TMF1	3	69096945	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	2038211	69096945	128925485	54	45489											
ARL13B	200894	broad.mit.edu	37	chr3	93714736	93714737	+	Missense_Mutation	DNP	GG	TT	TT																															agaaaggtgactcttttgatGgtgggacttgataatgctgg																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:93714736_93714737GG>TT	uc003drc.2	+	2	364_365	c.78_79GG>TT	c.(76-81)ATGGTG>ATTTTG	p.26_27MV>IL	ARL13B_uc010hop.2_5'UTR|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_5'UTR|ARL13B_uc003drf.2_Missense_Mutation_p.26_27MV>IL|ARL13B_uc003drg.2_Intron	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	26_27							GTP binding				0						CTCTTTTGATGGTGGGACTTGA	0.287													8	21					0	0	0	0	TT	93714737	TT	TT	93714736	3	4	248	1	0	0	0	0	1	0	0	0	929	1348	47	4	84	4	ARL13B	3	93714736	Missense_Mutation	DNP	GG	TCGA-CV-7409-01A-31D-2229-08	24617791	93714736	104307694	55	45490											
CCDC54	84692	broad.mit.edu	37	chr3	107097154	107097154	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagcaaagccaaatatttaCatttacccagacttcagtac	17	10	4	10	0	1	1	1	0	0	1	1	1	1	1	2	0	5	2	2	0	7	7			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:107097154C>T	uc003dwi.1	+	1	967	c.720C>T	c.(718-720)TAC>TAT	p.Y240Y		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	240											0						CAAATATTTACATTTACCCAG	0.353													29	91					0	0	0	0	T	107097154	T	T	107097154	2	4	248	1	0	0	0	0	0	0	0	1	2837	489	17	4		4	CCDC54	3	107097154	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	13382418	107097154	90925276	56	45491											
DPPA4	55211	broad.mit.edu	37	chr3	109052773	109052773	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttgctgatgttcctggcAaagcaattgaatttggttga	9	16	10	6	0	1	3	0	3	1	0	2	3	2	3	1	2	2	5	1	2	3	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:109052773A>C	uc003dxq.3	-	2	177	c.122T>G	c.(121-123)TTG>TGG	p.L41W	DPPA4_uc011bho.1_Missense_Mutation_p.L41W|DPPA4_uc011bhp.1_Missense_Mutation_p.L41W	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	41						nucleus	protein binding			upper_aerodigestive_tract(1)	1						TGTTCCTGGCAAAGCAATTGA	0.453													34	46					0	0	0	0	C	109052773	C	C	109052773	3	2	248	1	0	0	0	0	1	0	0	0	4758	131	5	5	816	5	DPPA4	3	109052773	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	1955619	109052773	88969657	57	45492											
GOLGB1	2804	broad.mit.edu	37	chr3	121413564	121413564	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatgcttccattaagttctgCtaattgattcataagcctct	11	16	5	9	0	3	1	1	1	2	0	4	1	4	1	2	0	3	3	2	0	4	7			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:121413564C>A	uc003eei.3	-	13	5917	c.5791G>T	c.(5791-5793)GCA>TCA	p.A1931S	GOLGB1_uc010hrc.2_Missense_Mutation_p.A1936S|GOLGB1_uc003eej.3_Missense_Mutation_p.A1897S|GOLGB1_uc011bjm.1_Missense_Mutation_p.A1817S|GOLGB1_uc010hrd.1_Missense_Mutation_p.A1895S	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1931	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTAAGTTCTGCTAATTGATTC	0.363													62	98					1.33661e-31	1.82934e-31	1	0	A	121413564	A	A	121413564	3	1	248	1	0	0	0	0	1	0	0	0	6602	797	28	4	4028	4	GOLGB1	3	121413564	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	12360791	121413564	76608866	58	45493											
PPP2R3A	5523	broad.mit.edu	37	chr3	135721837	135721837	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaagagggagaccagagagaTtttacaaattccagtagcca	16	7	11	7	0	0	4	0	0	0	4	1	7	1	4	3	1	2	1	3	1	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:135721837T>C	uc003eqv.1	+	2	2062	c.1497T>C	c.(1495-1497)GAT>GAC	p.D499D	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	499					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						ACCAGAGAGATTTTACAAATT	0.338													13	41					0	0	0	0	C	135721837	C	C	135721837	2	2	248	1	0	0	0	0	0	0	0	1	12448	1490	52	5		5	PPP2R3A	3	135721837	Silent	SNP	T	TCGA-CV-7409-01A-31D-2229-08	14308273	135721837	62300593	59	45494											
CP	1356	broad.mit.edu	37	chr3	148916310	148916310	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cctacttctttggggacagtCcattcataggtgaatgtttc	8	15	9	9	0	2	1	1	1	1	0	4	2	3	2	2	3	1	1	2	3	3	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:148916310C>A	uc003ewy.3	-	9	1810	c.1557G>T	c.(1555-1557)TGG>TGT	p.W519C	CP_uc011bnr.1_RNA|CP_uc003ewx.3_Missense_Mutation_p.W300C|CP_uc003ewz.2_Missense_Mutation_p.W519C|CP_uc010hvf.1_Missense_Mutation_p.W245C	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	519	Plastocyanin-like 3.|F5/8 type A 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TGGGGACAGTCCATTCATAGG	0.468													13	40					6.31663e-08	7.05976e-08	1	0	A	148916310	A	A	148916310	3	1	248	1	0	0	0	0	1	0	0	0	3802	856	30	2	1684	2	CP	3	148916310	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	13194473	148916310	49106120	60	45495											
AADACL2	344752	broad.mit.edu	37	chr3	151474781	151474781	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattaccatatattttcaggTgcagaatgatgctgaaataa	15	14	7	5	0	1	3	1	2	0	1	1	3	1	3	1	1	3	2	1	1	7	7			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:151474781T>C	uc003ezc.2	+	5	725	c.605T>C	c.(604-606)GTG>GCG	p.V202A	AADACL2_uc010hvn.2_5'UTR	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	202						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TATTTTCAGGTGCAGAATGAT	0.303													24	34					0	0	0	0	C	151474781	C	C	151474781	3	2	248	1	0	0	0	0	1	0	0	0	11	1710	59	5	623	5	AADACL2	3	151474781	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	2558471	151474781	46547649	61	45496											
MME	4311	broad.mit.edu	37	chr3	154832816	154832816	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaacatggatgccaccaCtgagccttgtacagactttt	12	10	7	12	0	0	2	0	1	0	1	0	3	0	3	4	1	4	1	4	1	3	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:154832816C>A	uc010hvr.1	+	4	441	c.230C>A	c.(229-231)ACT>AAT	p.T77N	MME_uc003fab.1_Missense_Mutation_p.T77N|MME_uc003fac.1_Missense_Mutation_p.T77N|MME_uc003fad.1_Missense_Mutation_p.T77N|MME_uc003fae.1_Missense_Mutation_p.T77N	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	77	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GATGCCACCACTGAGCCTTGT	0.428													46	99					1.27862e-28	1.72081e-28	1	0	A	154832816	A	A	154832816	3	1	248	1	0	0	0	0	1	0	0	0	9698	565	20	4	240	4	MME	3	154832816	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	3358035	154832816	43189614	62	45497											
SLITRK3	22865	broad.mit.edu	37	chr3	164908119	164908119	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tacttaggttccgaaatgccCcactctcaatacgtttaatg	11	13	6	11	2	1	0	1	0	1	0	3	1	2	0	3	1	3	2	3	1	6	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:164908119C>G	uc003fej.3	-	2	944	c.500G>C	c.(499-501)GGG>GCG	p.G167A	SLITRK3_uc003fek.2_Missense_Mutation_p.G167A	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	167	LRR 4.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CCGAAATGCCCCACTCTCAAT	0.378										HNSCC(40;0.11)			20	54					0	0	0	0	G	164908119	G	G	164908119	3	3	248	1	0	0	0	0	1	0	0	0	14808	623	22	4	2437	4	SLITRK3	3	164908119	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	10075303	164908119	33114311	63	45498											
SPATA16	83893	broad.mit.edu	37	chr3	172737301	172737301	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctctgaatacctctccaGacatctaaacactgttgctt	11	12	5	13	0	3	2	0	1	3	1	4	2	3	2	3	0	4	2	3	0	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:172737301G>T	uc003fin.3	-	4	981	c.823C>A	c.(823-825)CTG>ATG	p.L275M		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	275					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TACCTCTCCAGACATCTAAAC	0.348													69	180					2.61895e-37	3.72652e-37	1	0	T	172737301	T	T	172737301	3	4	248	1	0	0	0	0	1	0	0	0	15067	933	33	2	918	2	SPATA16	3	172737301	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	7829182	172737301	25285129	64	45499											
ATP13A4	84239	broad.mit.edu	37	chr3	193183873	193183873	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatggtggctgttcctacaaGgcacaggaggaacctgatgg	11	8	14	8	0	0	1	0	1	0	0	1	3	1	3	2	6	2	3	2	6	4	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:193183873G>C	uc003ftd.2	-	11	1321	c.1213C>G	c.(1213-1215)CTT>GTT	p.L405V	ATP13A4_uc003fte.1_Missense_Mutation_p.L405V|ATP13A4_uc011bsr.1_Intron|ATP13A4_uc010hzi.2_RNA|ATP13A4_uc003ftf.3_Missense_Mutation_p.L111V	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	405	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GTTCCTACAAGGCACAGGAGG	0.453													89	370					0	0	0	0	C	193183873	C	C	193183873	3	2	248	1	0	0	0	0	1	0	0	0	1128	1000	35	4	2457	4	ATP13A4	3	193183873	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	20446572	193183873	4838557	65	45500											
KIAA0226	9711	broad.mit.edu	37	chr3	197427677	197427679	+	In_Frame_Del	DEL	GGA	-	-																															tctggcttctgggagctgctGgaggagaacaaattggaact																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr3:197427677_197427679delGGA	uc003fyc.2	-	7	1249_1251	c.1066_1068delTCC	c.(1066-1068)TCCdel	p.S359del	KIAA0226_uc003fyd.3_In_Frame_Del_p.S299del|KIAA0226_uc003fye.1_In_Frame_Del_p.S66del|KIAA0226_uc003fyf.2_In_Frame_Del_p.S192del|KIAA0226_uc003fyg.2_In_Frame_Del_p.S352del	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	359	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		GGGAGCTGCTGGAGGAGAACAAA	0.596													---	---	---								-	197427679	-	-	197427677	7	5	248	1	0	1	0	1	0	0	0	0	8201	1335	47	0	1955	0	KIAA0226	3	197427677	In_Frame_Del	DEL	GGA	TCGA-CV-7409-01A-31D-2229-08	4243804	197427677	594753	66	45501											
SPATA18	132671	broad.mit.edu	37	chr4	52944914	52944914	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgcaggaggcattccatgTagcaaaaatggcattcagac	13	9	11	8	0	1	1	1	0	0	1	2	2	2	2	1	3	2	5	1	3	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:52944914T>A	uc003gzl.2	+	8	1312	c.1034T>A	c.(1033-1035)GTA>GAA	p.V345E	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.V313E|SPATA18_uc003gzk.1_Missense_Mutation_p.V345E	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	345					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GCATTCCATGTAGCAAAAATG	0.393													23	70					0	0	0	0	A	52944914	A	A	52944914	3	1	248	1	0	0	0	0	1	0	0	0	15069	1638	57	5	1064	5	SPATA18	4	52944914	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08		52944914	138209362	67	45502											
UGT2A3	79799	broad.mit.edu	37	chr4	69796895	69796895	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agaagatcattctggggtatCcaatcatacagccgagtatt	13	11	9	8	1	3	2	2	0	1	2	4	3	4	2	2	2	2	2	2	2	5	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:69796895C>A	uc003hef.2	-	4	1093	c.1062G>T	c.(1060-1062)TGG>TGT	p.W354C	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	354	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TCTGGGGTATCCAATCATACA	0.373													18	36					7.4402e-23	9.53645e-23	1	0	A	69796895	A	A	69796895	3	1	248	1	0	0	0	0	1	0	0	0	17023	856	30	2	533	2	UGT2A3	4	69796895	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	16851981	69796895	121357381	68	45503											
ALB	213	broad.mit.edu	37	chr4	74274382	74274382	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatggtgaaatggctgactgCtgtgcaaaacaagaacctga	14	9	11	7	0	0	4	0	3	0	1	0	4	0	4	1	2	4	3	1	2	6	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:74274382C>A	uc003hgs.3	+	4	415	c.342C>A	c.(340-342)TGC>TGA	p.C114*	ALB_uc003hgw.3_Intron|ALB_uc011cbe.1_Intron|ALB_uc003hgt.3_Nonsense_Mutation_p.C114*|ALB_uc010iii.2_Intron|ALB_uc003hgu.3_Intron|ALB_uc003hgv.3_Intron|ALB_uc011cbf.1_Nonsense_Mutation_p.C4*|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'Flank	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	114	Albumin 1.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TGGCTGACTGCTGTGCAAAAC	0.438													11	40					1.58986e-06	1.70607e-06	1	0	A	74274382	A	A	74274382	4	1	248	1	0	0	0	0	0	1	0	0	486	805	28	4	356	4	ALB	4	74274382	Nonsense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	4477487	74274382	116879894	69	45504											
PPEF2	5470	broad.mit.edu	37	chr4	76813035	76813035	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttgctgcccagcatattctAtagactggaagatgctccag	10	11	9	11	0	1	2	0	0	1	2	2	3	2	3	2	1	4	3	2	1	4	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:76813035A>G	uc003hix.2	-	3	509	c.152T>C	c.(151-153)ATA>ACA	p.I51T	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.I51T	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	51					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AGCATATTCTATAGACTGGAA	0.592													35	63					0	0	0	0	G	76813035	G	G	76813035	3	3	248	1	0	0	0	0	1	0	0	0	12363	449	16	5	2169	5	PPEF2	4	76813035	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	2538653	76813035	114341241	70	45505											
PKD2	5311	broad.mit.edu	37	chr4	88968011	88968011	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggaattgtctggatgttGtgatcgttgtggtaggtttg	5	18	15	3	1	2	1	0	1	2	0	3	3	2	3	0	4	0	4	0	4	2	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:88968011G>T	uc003hre.2	+	6	1603	c.1537G>T	c.(1537-1539)GTG>TTG	p.V513L	PKD2_uc011cdf.1_Intron	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	513	Helical; (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		TCTGGATGTTGTGATCGTTGT	0.363													39	51					2.56175e-15	3.11069e-15	1	0	T	88968011	T	T	88968011	3	4	248	1	0	0	0	0	1	0	0	0	12021	1377	48	4	1559	4	PKD2	4	88968011	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	12154976	88968011	102186265	71	45506											
MMRN1	22915	broad.mit.edu	37	chr4	90874518	90874518	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaaggaacaattccagcCaagtttccccctgttactac	13	9	6	13	0	0	0	0	0	0	0	2	1	2	1	4	1	4	3	4	1	7	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:90874518C>A	uc003hst.2	+	8	3707	c.3636C>A	c.(3634-3636)GCC>GCA	p.A1212A	MMRN1_uc010iku.2_Silent_p.A515A|MMRN1_uc011cds.1_Silent_p.A954A	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1212	C1q.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CAATTCCAGCCAAGTTTCCCC	0.368													16	53					4.14922e-12	4.89123e-12	1	0	A	90874518	A	A	90874518	2	1	248	1	0	0	0	0	0	0	0	1	9723	581	21	4		4	MMRN1	4	90874518	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	1906507	90874518	100279758	72	45507											
TACR3	6870	broad.mit.edu	37	chr4	104512796	104512796	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaatatgatagggcagccaGcagatagcaaatgtcatgac	16	8	10	7	0	1	3	1	2	0	1	1	3	1	3	1	1	3	3	1	1	6	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:104512796G>T	uc003hxe.1	-	4	1076	c.933C>A	c.(931-933)TGC>TGA	p.C311*		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	311	Helical; Name=6; (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AGGGCAGCCAGCAGATAGCAA	0.343													18	19					1.45105e-14	1.74234e-14	1	0	T	104512796	T	T	104512796	4	4	248	1	0	0	0	0	0	1	0	0	15573	963	34	4	472	4	TACR3	4	104512796	Nonsense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	13638278	104512796	86641480	73	45508											
PDE5A	8654	broad.mit.edu	37	chr4	120422353	120422353	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttgcaagcagatggcatctAtgaacccaacttgcatactt	12	11	8	10	0	1	2	0	1	1	1	1	2	1	2	1	1	6	5	1	1	5	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:120422353A>G	uc003idh.2	-	20	2617	c.2462T>C	c.(2461-2463)ATA>ACA	p.I821T	uc003ide.3_Intron|PDE5A_uc003idf.2_Missense_Mutation_p.I779T|PDE5A_uc003idg.2_Missense_Mutation_p.I769T	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	821	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	GATGGCATCTATGAACCCAAC	0.348													11	51					0	0	0	0	G	120422353	G	G	120422353	3	3	248	1	0	0	0	0	1	0	0	0	11698	449	16	5	173	5	PDE5A	4	120422353	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	15909557	120422353	70731923	74	45509											
KIAA1109	84162	broad.mit.edu	37	chr4	123192226	123192226	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caaaccagcattaatgttggGaacctttagcatcagtgctg	12	11	9	9	0	1	0	1	0	0	0	1	1	1	1	2	1	5	4	2	1	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:123192226G>T	uc003ieh.2	+	45	7592	c.7547G>T	c.(7546-7548)GGA>GTA	p.G2516V	KIAA1109_uc003iel.1_Missense_Mutation_p.G451V|KIAA1109_uc003iek.2_Missense_Mutation_p.G1135V	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2516					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTAATGTTGGGAACCTTTAGC	0.418													20	31					1.64113e-05	1.72667e-05	1	0	T	123192226	T	T	123192226	3	4	248	1	0	0	0	0	1	0	0	0	8247	1174	41	2	7725	2	KIAA1109	4	123192226	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	2769873	123192226	67962050	75	45510											
RNF150	57484	broad.mit.edu	37	chr4	141888963	141888963	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcacggtgatgtttctttcCagcaggcttactatctcctt	6	16	8	11	1	3	1	1	1	2	0	5	1	4	1	2	2	2	3	2	2	2	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:141888963C>A	uc003iio.1	-	2	1203	c.549G>T	c.(547-549)CTG>CTT	p.L183L	RNF150_uc010iok.1_Silent_p.L183L|RNF150_uc003iip.1_Silent_p.L183L	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	183	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					TGTTTCTTTCCAGCAGGCTTA	0.478													64	120					1.1794e-34	1.65629e-34	1	0	A	141888963	A	A	141888963	2	1	248	1	0	0	0	0	0	0	0	1	13516	581	21	4		4	RNF150	4	141888963	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	18696737	141888963	49265313	76	45511											
HHIP	64399	broad.mit.edu	37	chr4	145580832	145580832	+	Missense_Mutation	SNP	G	T	T																															gtattcaggaggttgtgagtGggctgcggcagcccgttggt																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:145580832G>T	uc003ijs.1	+	4	1328	c.673G>T	c.(673-675)GGG>TGG	p.G225W	HHIP_uc003ijr.1_Missense_Mutation_p.G225W	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	225						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GGTTGTGAGTGGGCTGCGGCA	0.463													45	141					9.52127e-25	1.22525e-24	1	0	T	145580832	T	T	145580832	3	4	248	1	0	0	0	0	1	0	0	0	7131	1348	47	4	687	4	HHIP	4	145580832	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	3691869	145580832	45573444	77	45512	98	2									
HHIP	64399	broad.mit.edu	37	chr4	145580834	145580834	+	Silent	SNP	G	C	C																															attcaggaggttgtgagtggGctgcggcagcccgttggtgc																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:145580834G>C	uc003ijs.1	+	4	1330	c.675G>C	c.(673-675)GGG>GGC	p.G225G	HHIP_uc003ijr.1_Silent_p.G225G	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	225						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TTGTGAGTGGGCTGCGGCAGC	0.463													46	138					0	0	0	0	C	145580834	C	C	145580834	2	2	248	1	0	0	0	0	0	0	0	1	7131	1190	42	4		4	HHIP	4	145580834	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	2	145580834	45573442	78	45513	98	2									
KIAA0922	23240	broad.mit.edu	37	chr4	154525454	154525454	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattaaaacttcagagaacaCagccgagttcaaggaacggg	16	6	10	9	2	2	1	2	0	0	1	2	4	2	2	1	2	4	1	1	2	5	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:154525454C>T	uc003inm.3	+	25	3339	c.3287C>T	c.(3286-3288)ACA>ATA	p.T1096I	KIAA0922_uc010ipp.2_Missense_Mutation_p.T1097I|KIAA0922_uc010ipq.2_Missense_Mutation_p.T865I	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1096	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				TCAGAGAACACAGCCGAGTTC	0.423													21	39					0	0	0	0	T	154525454	T	T	154525454	3	4	248	1	0	0	0	0	1	0	0	0	8240	478	17	4	3388	4	KIAA0922	4	154525454	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	8944620	154525454	36628822	79	45514											
TLR2	7097	broad.mit.edu	37	chr4	154625775	154625775	+	Frame_Shift_Del	DEL	C	-	-																															tctccatcccatgtgcgtggCcagcaggttcaggatgtccg																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:154625775delC	uc003inq.2	+	3	1935	c.1716delC	c.(1714-1716)GGCfs	p.G572fs	TLR2_uc003inr.2_Frame_Shift_Del_p.G572fs|TLR2_uc003ins.2_Frame_Shift_Del_p.G572fs	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	572	Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				ATGTGCGTGGCCAGCAGGTTC	0.552													---	---	---								-	154625775	-	-	154625775	7	5	248	1	0	1	0	1	0	0	0	0	16017	726	26	0	1718	0	TLR2	4	154625775	Frame_Shift_Del	DEL	C	TCGA-CV-7409-01A-31D-2229-08	100321	154625775	36528501	80	45515											
DCHS2	54798	broad.mit.edu	37	chr4	155176799	155176799	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaatcaggccgttcaaaccActgtccaagtcggtagcaaa	13	8	8	12	2	3	0	3	0	0	0	5	0	4	0	3	2	2	3	3	2	5	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:155176799A>G	uc003inw.2	-	21	5448	c.5448T>C	c.(5446-5448)AGT>AGC	p.S1816S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1816	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CGTTCAAACCACTGTCCAAGT	0.413													15	46					0	0	0	0	G	155176799	G	G	155176799	2	3	248	1	0	0	0	0	0	0	0	1	4305	156	6	5		5	DCHS2	4	155176799	Silent	SNP	A	TCGA-CV-7409-01A-31D-2229-08	551024	155176799	35977477	81	45516											
GUCY1B3	2983	broad.mit.edu	37	chr4	156726337	156726337	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccatgaagggcaaaaaagaaCcaatgcaagtttggtttcta	16	9	9	7	0	1	2	0	1	1	1	1	2	1	2	2	2	2	4	2	2	8	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:156726337C>T	uc003ipc.2	+	13	1959	c.1792C>T	c.(1792-1794)CCA>TCA	p.P598S	GUCY1B3_uc011cio.1_Missense_Mutation_p.P620S|GUCY1B3_uc011cip.1_Missense_Mutation_p.P578S|GUCY1B3_uc003ipd.2_Missense_Mutation_p.P526S|GUCY1B3_uc010iqf.2_Missense_Mutation_p.P565S|GUCY1B3_uc010iqg.2_Missense_Mutation_p.P569S|GUCY1B3_uc011ciq.1_Missense_Mutation_p.P526S	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	598					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		CAAAAAAGAACCAATGCAAGT	0.388													8	16					0	0	0	0	T	156726337	T	T	156726337	3	4	248	1	0	0	0	0	1	0	0	0	6934	507	18	4	1842	4	GUCY1B3	4	156726337	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	1549538	156726337	34427939	82	45517											
CTSO	1519	broad.mit.edu	37	chr4	156858588	156858588	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagtaatggcacagaccattTtgtgctttaaaaggatattc	14	13	8	6	0	0	1	0	0	0	1	1	2	0	2	1	2	1	3	1	2	5	7			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:156858588T>C	uc003ipg.2	-	5	649	c.600A>G	c.(598-600)CAA>CAG	p.Q200Q		NM_001334	NP_001325	P43234	CATO_HUMAN	cathepsin O preproprotein	200					proteolysis	lysosome	cysteine-type endopeptidase activity				0	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		ACAGACCATTTTGTGCTTTAA	0.299													16	22					0	0	0	0	C	156858588	C	C	156858588	2	2	248	1	0	0	0	0	0	0	0	1	4057	1838	64	5		5	CTSO	4	156858588	Silent	SNP	T	TCGA-CV-7409-01A-31D-2229-08	132251	156858588	34295688	83	45518											
ADAM29	11086	broad.mit.edu	37	chr4	175896994	175896994	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctactatcatggttatgtGgaaggggacccagaatccct	10	11	11	9	0	1	1	1	0	0	1	2	3	2	3	2	4	2	2	2	4	5	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:175896994G>T	uc003iuc.2	+	5	988	c.318G>T	c.(316-318)GTG>GTT	p.V106V	ADAM29_uc003iud.2_Silent_p.V106V|ADAM29_uc010irr.2_Silent_p.V106V|ADAM29_uc011cki.1_Silent_p.V106V	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	106					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ATGGTTATGTGGAAGGGGACC	0.453													22	56					8.10497e-08	8.99624e-08	1	0	T	175896994	T	T	175896994	2	4	248	1	0	0	0	0	0	0	0	1	247	1335	47	4		4	ADAM29	4	175896994	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	19038406	175896994	15257282	84	45519											
FAT1	2195	broad.mit.edu	37	chr4	187531167	187531167	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	attctcaatgataaatacggCccctgaatagaaatcaaaat	18	10	5	8	1	2	3	2	2	1	1	3	3	2	3	2	1	1	0	2	1	9	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr4:187531167C>G	uc003izf.2	-	15	10044	c.9856G>C	c.(9856-9858)GCC>CCC	p.A3286P		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3286	Extracellular (Potential).|Cadherin 30.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATAAATACGGCCCCTGAATAG	0.413										HNSCC(5;0.00058)			7	12					0	0	0	0	G	187531167	G	G	187531167	3	3	248	1	0	0	0	0	1	0	0	0	5721	739	26	4	3962	4	FAT1	4	187531167	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	11634173	187531167	3623109	85	45520											
KIAA0947	23379	broad.mit.edu	37	chr5	5461973	5461973	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatcttcttagagaaaataaCaatcctgtagaattcaagac	17	11	6	7	0	3	3	1	0	2	3	4	5	4	3	1	0	1	1	1	0	8	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:5461973C>A	uc003jdm.3	+	13	2748	c.2526C>A	c.(2524-2526)AAC>AAA	p.N842K		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	842										ovary(1)|central_nervous_system(1)	2						GAGAAAATAACAATCCTGTAG	0.408													28	27					1.75199e-13	2.09589e-13	1	0	A	5461973	A	A	5461973	3	1	248	1	0	0	0	0	1	0	0	0	8241	477	17	4	2576	4	KIAA0947	5	5461973	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08		5461973	175453287	86	45521											
CTNND2	1501	broad.mit.edu	37	chr5	11098693	11098693	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaactggccataccttccaGctccctgcagccaagttctg	8	10	8	15	0	1	1	0	1	1	0	3	1	3	1	5	1	5	3	5	1	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:11098693G>T	uc003jfa.1	-	15	2776	c.2631C>A	c.(2629-2631)AGC>AGA	p.S877R	CTNND2_uc010itt.2_Missense_Mutation_p.S786R|CTNND2_uc011cmy.1_Missense_Mutation_p.S540R|CTNND2_uc011cmz.1_Missense_Mutation_p.S444R|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.S444R	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	877					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						ATACCTTCCAGCTCCCTGCAG	0.468													30	50					7.11191e-15	8.57144e-15	1	0	T	11098693	T	T	11098693	3	4	248	1	0	0	0	0	1	0	0	0	4037	962	34	4	1078	4	CTNND2	5	11098693	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	5636720	11098693	169816567	87	45522											
FBXL7	23194	broad.mit.edu	37	chr5	15937219	15937219	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtccaggactgcgaggtctCcgtggaggccctgcgctttg	4	10	15	12	3	1	0	0	0	1	0	3	3	2	2	3	4	2	1	3	4	0	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:15937219C>A	uc003jfn.1	+	4	1881	c.1400C>A	c.(1399-1401)TCC>TAC	p.S467Y		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	467					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						TGCGAGGTCTCCGTGGAGGCC	0.607													25	18					3.83957e-06	4.10656e-06	1	0	A	15937219	A	A	15937219	3	1	248	1	0	0	0	0	1	0	0	0	5756	855	30	2	1414	2	FBXL7	5	15937219	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	4838526	15937219	164978041	88	45523											
RXFP3	51289	broad.mit.edu	37	chr5	33937334	33937334	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgtgtccatggtgacgtcCatgaacatgtacgccagcgt	9	10	11	11	4	0	2	0	2	0	0	3	2	2	2	3	1	3	1	3	1	2	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:33937334C>A	uc003jic.1	+	1	846	c.489C>A	c.(487-489)TCC>TCA	p.S163S		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	163	Helical; Name=3; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						TGGTGACGTCCATGAACATGT	0.582													63	62					7.75977e-34	1.08502e-33	1	0	A	33937334	A	A	33937334	2	1	248	1	0	0	0	0	0	0	0	1	13826	581	21	4		4	RXFP3	5	33937334	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	18000115	33937334	146977926	89	45524											
EGFLAM	133584	broad.mit.edu	37	chr5	38407018	38407018	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctaacccaaagaccatttCtaggctcatcccccctacct	11	10	3	17	0	3	1	1	0	2	1	4	1	4	1	6	1	2	1	6	1	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:38407018C>A	uc003jlc.1	+	8	1241	c.917C>A	c.(916-918)TCT>TAT	p.S306Y	EGFLAM_uc003jlb.1_Missense_Mutation_p.S306Y|EGFLAM_uc003jle.1_Missense_Mutation_p.S72Y|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	306						cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					AAGACCATTTCTAGGCTCATC	0.483													26	108					1.5548e-18	1.939e-18	1	0	A	38407018	A	A	38407018	3	1	248	1	0	0	0	0	1	0	0	0	4988	913	32	2	961	2	EGFLAM	5	38407018	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	4469684	38407018	142508242	90	45525											
ATP6AP1L	92270	broad.mit.edu	37	chr5	81614007	81614007	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcatcgcctctcctgcccActtctcgcagctgaaagctc	6	11	6	18	2	3	1	1	1	3	0	8	1	3	1	3	0	3	3	3	0	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:81614007A>T	uc003khv.2	+	10	1888	c.563A>T	c.(562-564)CAC>CTC	p.H188L	ATP6AP1L_uc003khw.2_Missense_Mutation_p.H188L	NM_001017971	NP_001017971	Q52LC2	VAS1L_HUMAN	ATPase, H+ transporting, lysosomal accessory	188					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0						TCTCCTGCCCACTTCTCGCAG	0.537													61	33					0	0	0	0	T	81614007	T	T	81614007	3	4	248	1	0	0	0	0	1	0	0	0	1168	159	6	5	577	5	ATP6AP1L	5	81614007	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	43206989	81614007	99301253	91	45526											
GLRX	2745	broad.mit.edu	37	chr5	95158243	95158243	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatcgacaaattccagaaGcccttgtttgatgggcaatt	12	12	9	8	1	0	2	0	1	0	1	2	4	1	2	2	1	1	2	2	1	4	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:95158243G>T	uc003klo.3	-	1	335	c.124C>A	c.(124-126)CTT>ATT	p.L42I	GLRX_uc003kln.3_Missense_Mutation_p.L42I	NM_001118890	NP_001112362	P35754	GLRX1_HUMAN	glutaredoxin (thioltransferase)	42	Glutaredoxin.				cell redox homeostasis|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|transport	cytosol	electron carrier activity|glutathione disulfide oxidoreductase activity|protein disulfide oxidoreductase activity|protein N-terminus binding				0		all_cancers(142;3.38e-06)|all_epithelial(76;5.66e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;2.62e-16)	Glutathione(DB00143)	AATTCCAGAAGCCCTTGTTTG	0.483													85	49					1.90436e-54	2.84772e-54	1	0	T	95158243	T	T	95158243	3	4	248	1	0	0	0	0	1	0	0	0	6496	971	34	4	204	4	GLRX	5	95158243	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	13544236	95158243	85757017	92	45527											
PRR16	51334	broad.mit.edu	37	chr5	120022149	120022151	+	In_Frame_Del	DEL	TGA	-	-																															catggctattgtcctgactgTgatacccggtataacataaa																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:120022149_120022151delTGA	uc003ksq.2	+	2	823_825	c.660_662delTGA	c.(658-663)TGTGAT>TGT	p.D221del	PRR16_uc003ksp.2_In_Frame_Del_p.D198del|PRR16_uc003ksr.2_In_Frame_Del_p.D151del	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	221	Pro-rich.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		GTCCTGACTGTGATACCCGGTAT	0.498													---	---	---								-	120022151	-	-	120022149	7	5	248	1	0	1	0	1	0	0	0	0	12651	1702	59	0	597	0	PRR16	5	120022149	In_Frame_Del	DEL	TGA	TCGA-CV-7409-01A-31D-2229-08	24863906	120022149	60893111	93	45528											
ZNF608	57507	broad.mit.edu	37	chr5	124036938	124036943	+	In_Frame_Del	DEL	CTGGCA	-	-																															ggaaatcggcggtggtggcgCtggcactgtaaacagggggt																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:124036938_124036943delCTGGCA	uc003ktq.1	-	2	1049_1054	c.926_931delTGCCAG	c.(925-933)GTGCCAGCG>GCG	p.VP309del	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_In_Frame_Del_p.VP309del|ZNF608_uc003ktt.1_In_Frame_Del_p.VP309del	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	309_310	Poly-Pro.					intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GGTGGTGGCGCTGGCACTGTAAACAG	0.476													---	---	---								-	124036943	-	-	124036938	7	5	248	1	0	1	0	1	0	0	0	0	18101	797	28	0	3639	0	ZNF608	5	124036938	In_Frame_Del	DEL	CTGGCA	TCGA-CV-7409-01A-31D-2229-08	4014789	124036938	56878322	94	45529											
MEGF10	84466	broad.mit.edu	37	chr5	126732333	126732333	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cactgtgctgcgggcttccgGggctggcgctgcgaggaccg	3	7	18	13	5	0	0	0	0	0	0	1	2	1	1	2	5	3	4	2	5	0	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:126732333G>T	uc003kuh.3	+	7	884	c.522G>T	c.(520-522)CGG>CGT	p.R174R	MEGF10_uc010jdc.1_Silent_p.R174R|MEGF10_uc010jdd.1_Silent_p.R174R|MEGF10_uc003kui.3_Silent_p.R174R	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	174	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EGF-like 2.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CGGGCTTCCGGGGCTGGCGCT	0.642													47	32					6.7651e-33	9.37823e-33	1	0	T	126732333	T	T	126732333	2	4	248	1	0	0	0	0	0	0	0	1	9513	1219	43	4		4	MEGF10	5	126732333	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	2695395	126732333	54182927	95	45530											
FBXL21	26223	broad.mit.edu	37	chr5	135276290	135276290	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attgaagattcttgtggccaAtaatagtgacactctaagac	14	12	8	7	0	2	4	0	2	2	2	2	4	2	4	1	1	0	0	1	1	5	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:135276290A>T	uc010jec.1	+	4	623	c.602A>T	c.(601-603)AAT>ATT	p.N201I	FBXL21_uc003lbc.2_RNA	NM_012159	NP_036291	Q9UKT6	FXL21_HUMAN	F-box and leucine-rich repeat protein 21	201	LRR 2.				rhythmic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTTGTGGCCAATAATAGTGAC	0.333													8	31					0	0	0	0	T	135276290	T	T	135276290	3	4	248	1	0	0	0	0	1	0	0	0	5750	101	4	5	612	5	FBXL21	5	135276290	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	8543957	135276290	45638970	96	45531											
CD74	972	broad.mit.edu	37	chr5	149792229	149792229	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggcccagcatgggcagttgCtcattgttggagataaggtc	8	10	14	9	1	1	1	1	0	0	1	2	2	1	1	1	4	2	5	1	4	1	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:149792229C>G	uc003lsc.2	-	1	95	c.84G>C	c.(82-84)GAG>GAC	p.E28D	CD74_uc003lse.2_Missense_Mutation_p.E28D|CD74_uc003lsd.2_Missense_Mutation_p.E28D|CD74_uc003lsf.1_Missense_Mutation_p.E28D	NM_001025159	NP_001020330	P04233	HG2A_HUMAN	CD74 antigen isoform a	28	Cytoplasmic (Potential).				antigen processing and presentation of endogenous antigen|cell proliferation|immunoglobulin mediated immune response|intracellular protein transport|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of peptide secretion|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of cytokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of macrophage cytokine production|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|prostaglandin biosynthetic process|protein complex assembly|regulation of macrophage activation	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|lysosome|receptor complex	beta-amyloid binding|cytokine receptor activity|identical protein binding|MHC class II protein binding			breast(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGGCAGTTGCTCATTGTTGG	0.622			T	ROS1	NSCLC								158	96					0	0	0	0	G	149792229	G	G	149792229	3	3	248	1	0	0	0	0	1	0	0	0	3050	796	28	4	842	4	CD74	5	149792229	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	14515939	149792229	31123031	97	45532											
ADAM19	8728	broad.mit.edu	37	chr5	156908860	156908860	+	Frame_Shift_Del	DEL	G	-	-																															cagcaccagggggccgcagtGgggatgcacctcctggcctg																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:156908860delG	uc003lwz.2	-	22	2706	c.2642delC	c.(2641-2643)CCAfs	p.P881fs	ADAM19_uc003lww.1_Intron|ADAM19_uc003lwy.2_Frame_Shift_Del_p.P480fs|ADAM19_uc011ddr.1_Frame_Shift_Del_p.P812fs	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	881	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGGCCGCAGTGGGGATGCACC	0.682													---	---	---								-	156908860	-	-	156908860	7	5	248	1	0	1	0	1	0	0	0	0	240	1348	47	0	122	0	ADAM19	5	156908860	Frame_Shift_Del	DEL	G	TCGA-CV-7409-01A-31D-2229-08	7116631	156908860	24006400	98	45533											
ADAM19	8728	broad.mit.edu	37	chr5	156920125	156920125	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggtgtcaatgggcaccgcGttggactccaggggccgggc	5	7	18	11	3	1	0	1	0	0	0	2	1	2	1	3	6	0	2	3	6	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:156920125G>T	uc003lwz.2	-	16	1828	c.1764C>A	c.(1762-1764)AAC>AAA	p.N588K	ADAM19_uc003lww.1_Missense_Mutation_p.N321K|ADAM19_uc003lwy.2_Missense_Mutation_p.N187K|ADAM19_uc011ddr.1_Missense_Mutation_p.N519K	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	588	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGGCACCGCGTTGGACTCCA	0.597													73	63					1.42536e-29	1.92632e-29	1	0	T	156920125	T	T	156920125	3	4	248	1	0	0	0	0	1	0	0	0	240	1136	40	3	1024	3	ADAM19	5	156920125	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	11265	156920125	23995135	99	45534											
CLINT1	9685	broad.mit.edu	37	chr5	157218892	157218892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccactaacaagttctaccGctggctgtgaggcactgcca	10	8	10	13	1	1	1	0	1	1	0	1	1	1	1	3	2	4	4	3	2	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:157218892G>A	uc003lxj.1	-	10	1389	c.1199C>T	c.(1198-1200)GCG>GTG	p.A400V	CLINT1_uc003lxg.1_5'Flank|CLINT1_uc003lxh.1_5'UTR|CLINT1_uc003lxi.1_Missense_Mutation_p.A382V|CLINT1_uc011ddv.1_Missense_Mutation_p.A400V	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	400					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AAGTTCTACCGCTGGCTGTGA	0.547													23	15					0	0	0	0	A	157218892	A	A	157218892	3	1	248	1	0	0	0	0	1	0	0	0	3546	1087	38	1	690	1	CLINT1	5	157218892	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	298767	157218892	23696368	100	45535											
NSD1	64324	broad.mit.edu	37	chr5	176638857	176638857	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaactcaatggtgtaaatCaagtggtgcctaaaaagcgg	15	9	11	6	1	2	1	2	1	0	0	2	1	2	1	1	3	3	1	1	3	8	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr5:176638857C>T	uc003mfr.3	+	5	3595	c.3457C>T	c.(3457-3459)CAA>TAA	p.Q1153*	NSD1_uc003mft.3_Nonsense_Mutation_p.Q884*|NSD1_uc003mfs.1_Nonsense_Mutation_p.Q1050*|NSD1_uc011dfx.1_Nonsense_Mutation_p.Q801*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1153					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TGGTGTAAATCAAGTGGTGCC	0.418			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			28	15					0	0	0	0	T	176638857	T	T	176638857	4	4	248	1	0	0	0	0	0	1	0	0	10723	827	29	2	3471	2	NSD1	5	176638857	Nonsense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	19419965	176638857	4276403	101	45536											
HIST1H3A	8350	broad.mit.edu	37	chr6	26020994	26020994	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagctccgctgtgatggctCtgcaggaggcgtgcgaggcc	6	7	17	11	3	1	2	0	1	1	1	2	4	2	3	2	4	3	4	2	4	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr6:26020994C>A	uc003nfp.1	+	1	277	c.277C>A	c.(277-279)CTG>ATG	p.L93M	HIST1H1A_uc003nfo.2_5'Flank|HIST1H4A_uc003nfq.2_5'Flank	NM_003529	NP_003520	P68431	H31_HUMAN	histone cluster 1, H3a	93					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)|pancreas(1)	2						TGTGATGGCTCTGCAGGAGGC	0.552													24	14					2.08973e-25	2.73272e-25	1	0	A	26020994	A	A	26020994	3	1	248	1	0	0	0	0	1	0	0	0	7194	912	32	2	279	2	HIST1H3A	6	26020994	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08		26020994	145094073	102	45537											
ZNF192	7745	broad.mit.edu	37	chr6	28121695	28121695	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcacacaggggagaagccctAccaatgtaatgagtgtggga	13	7	13	8	0	1	2	1	1	0	1	1	4	1	3	2	3	2	1	2	3	4	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr6:28121695A>G	uc003nkn.1	+	6	1821	c.1637A>G	c.(1636-1638)TAC>TGC	p.Y546C	ZNF192_uc010jqx.1_Missense_Mutation_p.Y546C|ZNF192_uc010jqy.1_Missense_Mutation_p.Y359C|ZNF192_uc011dkz.1_Missense_Mutation_p.Y359C	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	546	C2H2-type 9.				viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GAGAAGCCCTACCAATGTAAT	0.423													43	25					0	0	0	0	G	28121695	G	G	28121695	3	3	248	1	0	0	0	0	1	0	0	0	17823	391	14	5	1655	5	ZNF192	6	28121695	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	2100701	28121695	142993372	103	45538											
COL11A2	1302	broad.mit.edu	37	chr6	33136530	33136530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcggtcacccttagcaccatCctggccctgcagaagtgaag	9	8	10	14	1	1	2	1	1	0	1	3	2	2	2	4	2	2	2	4	2	3	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr6:33136530C>G	uc003ocx.1	-	53	4087	c.3859G>C	c.(3859-3861)GAT>CAT	p.D1287H	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.D1201H|COL11A2_uc003ocz.1_Missense_Mutation_p.D1180H	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1287	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TTAGCACCATCCTGGCCCTGC	0.617													8	6					0	0	0	0	G	33136530	G	G	33136530	3	3	248	1	0	0	0	0	1	0	0	0	3683	855	30	2	1407	2	COL11A2	6	33136530	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	5014835	33136530	137978537	104	45539											
OPN5	221391	broad.mit.edu	37	chr6	47749839	47749839	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgccctgcctcaggacgagCgcctgccccattaccttcga	6	8	9	18	3	1	0	1	0	0	0	2	3	1	1	6	1	5	0	6	1	1	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr6:47749839C>A	uc003ozc.2	+	1	42	c.37C>A	c.(37-39)CGC>AGC	p.R13S		NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	13	Extracellular (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						TCAGGACGAGCGCCTGCCCCA	0.478													47	31					4.46115e-38	6.37589e-38	1	0	A	47749839	A	A	47749839	3	1	248	1	0	0	0	0	1	0	0	0	10937	768	27	3	39	3	OPN5	6	47749839	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	14613309	47749839	123365228	105	45540											
RIMS1	22999	broad.mit.edu	37	chr6	72970465	72970465	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtgcagaatgcctacatacTaccaggtaaatacagggatt	15	9	9	8	0	0	1	0	0	0	1	0	2	0	2	2	2	6	2	2	2	7	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr6:72970465T>C	uc003pga.2	+	19	3188	c.3111T>C	c.(3109-3111)ACT>ACC	p.T1037T	RIMS1_uc011dyb.1_Intron|RIMS1_uc003pgc.2_Silent_p.T663T|RIMS1_uc010kaq.2_Silent_p.T510T|RIMS1_uc011dyc.1_Silent_p.T511T|RIMS1_uc010kar.2_Silent_p.T430T|RIMS1_uc011dyd.1_Silent_p.T496T|RIMS1_uc003pgf.2_Silent_p.T253T|RIMS1_uc003pgg.2_Silent_p.T254T|RIMS1_uc003pgi.2_Intron|RIMS1_uc003pgh.2_Silent_p.T253T|RIMS1_uc003pgd.2_Silent_p.T254T|RIMS1_uc003pge.2_Silent_p.T254T|RIMS1_uc011dye.1_Silent_p.T16T|RIMS1_uc011dyf.1_Silent_p.T16T|RIMS1_uc003pgb.3_Silent_p.T663T|RIMS1_uc010kas.1_Silent_p.T496T	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1037					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GCCTACATACTACCAGGTAAA	0.433													13	20					0	0	0	0	C	72970465	C	C	72970465	2	2	248	1	0	0	0	0	0	0	0	1	13432	1509	53	5		5	RIMS1	6	72970465	Silent	SNP	T	TCGA-CV-7409-01A-31D-2229-08	25220626	72970465	98144602	106	45541											
MANEA	79694	broad.mit.edu	37	chr6	96054237	96054237	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggtctgaaaaatacagtaagGaaagagcaacttatgcatta	18	9	9	5	0	1	2	0	1	1	1	1	3	1	3	0	2	4	3	0	2	8	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr6:96054237G>C	uc003poo.1	+	5	1485	c.1345G>C	c.(1345-1347)GAA>CAA	p.E449Q		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	449	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		ATACAGTAAGGAAAGAGCAAC	0.353													42	12					0	0	0	0	C	96054237	C	C	96054237	3	2	248	1	0	0	0	0	1	0	0	0	9274	1175	41	2	1359	2	MANEA	6	96054237	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	23083772	96054237	75060830	107	45542											
RSPO3	84870	broad.mit.edu	37	chr6	127471623	127471623	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaaatttctgcacaaaatgTaaaagtggattttacttaca	18	13	5	5	0	1	0	0	0	1	0	1	1	1	1	0	1	3	2	0	1	8	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr6:127471623T>A	uc003qar.2	+	3	632	c.342T>A	c.(340-342)TGT>TGA	p.C114*	RSPO3_uc003qas.1_Nonsense_Mutation_p.C114*	NM_032784	NP_116173	Q9BXY4	RSPO3_HUMAN	R-spondin 3 precursor	114	FU 2.					extracellular region	heparin binding				0				GBM - Glioblastoma multiforme(226;0.0555)		GCACAAAATGTAAAAGTGGAT	0.373													45	25					0	0	0	0	A	127471623	A	A	127471623	4	1	248	1	0	0	0	0	0	1	0	0	13776	1644	57	5	352	5	RSPO3	6	127471623	Nonsense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	31417386	127471623	43643444	108	45543											
ESR1	2099	broad.mit.edu	37	chr6	152129441	152129441	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccagcaggtgccctactacCtggagaacgagcccagcggc	9	4	13	15	2	0	1	0	0	0	1	0	3	0	1	4	3	7	1	4	3	3	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr6:152129441C>A	uc003qom.3	+	3	764	c.394C>A	c.(394-396)CTG>ATG	p.L132M	ESR1_uc010kin.2_Missense_Mutation_p.L132M|ESR1_uc010kio.2_Missense_Mutation_p.L132M|ESR1_uc010kip.2_Missense_Mutation_p.L132M|ESR1_uc003qon.3_Missense_Mutation_p.L132M|ESR1_uc003qoo.3_Missense_Mutation_p.L132M|ESR1_uc010kiq.2_Translation_Start_Site|ESR1_uc010kir.2_Missense_Mutation_p.L132M	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	132	Modulating; mediates interaction with MACROD1.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	GCCCTACTACCTGGAGAACGA	0.552													5	9					3.09899e-07	3.38166e-07	1	0	A	152129441	A	A	152129441	3	1	248	1	0	0	0	0	1	0	0	0	5280	680	24	4	396	4	ESR1	6	152129441	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	24657818	152129441	18985626	109	45544											
SYNE1	23345	broad.mit.edu	37	chr6	152539539	152539539	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcataatcaagaactccagcCtttttttccacaaaagaaat	16	12	3	10	0	2	2	2	0	0	2	4	2	4	2	3	0	2	0	3	0	6	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr6:152539539C>A	uc010kiw.2	-	121	22647	c.22045_splice	c.e121-1	p.A7349_splice	SYNE1_uc010kiv.2_Splice_Site_p.A1873_splice|SYNE1_uc003qos.3_Splice_Site_p.A1873_splice|SYNE1_uc003qot.3_Splice_Site_p.A7278_splice|SYNE1_uc003qou.3_Splice_Site_p.A7349_splice|SYNE1_uc003qor.3_Splice_Site_p.A249_splice	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAACTCCAGCCTTTTTTTCCA	0.343										HNSCC(10;0.0054)			67	49					2.02627e-32	2.79695e-32	1	0	A	152539539	A	A	152539539	5	1	248	1	0	0	0	0	0	0	1	0	15511	695	24	4	4526	4	SYNE1	6	152539539	Splice_Site	SNP	C	TCGA-CV-7409-01A-31D-2229-08	410098	152539539	18575528	110	45545											
CREB5	9586	broad.mit.edu	37	chr7	28547350	28547350	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaggaagaggagagcagcAagcgggtaggtttgcttgga	11	7	17	6	1	1	2	1	0	0	2	1	5	1	4	0	5	4	5	0	5	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:28547350A>T	uc003szq.2	+	4	676	c.286A>T	c.(286-288)AAG>TAG	p.K96*	CREB5_uc003szo.2_Nonsense_Mutation_p.K63*|CREB5_uc003szr.2_Nonsense_Mutation_p.K89*	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	96					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GGAGAGCAGCAAGCGGGTAGG	0.562													54	141					0	0	0	0	T	28547350	T	T	28547350	4	4	248	1	0	0	0	0	0	1	0	0	3875	131	5	5	300	5	CREB5	7	28547350	Nonsense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08		28547350	130591313	111	45546											
ADCYAP1R1	117	broad.mit.edu	37	chr7	31123764	31123764	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttgctgcagacatgggaGtggtgagccggaactgcacg	8	10	15	8	2	0	2	0	1	0	1	0	4	0	4	1	3	5	3	1	3	1	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:31123764G>T	uc003tca.1	+	7	560	c.337G>T	c.(337-339)GTG>TTG	p.V113L	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.V92L|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.V113L|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.V113L|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.V113L|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	113	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						AGACATGGGAGTGGTGAGCCG	0.478													24	117					1.66031e-10	1.90846e-10	1	0	T	31123764	T	T	31123764	3	4	248	1	0	0	0	0	1	0	0	0	303	1029	36	4	359	4	ADCYAP1R1	7	31123764	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	2576414	31123764	128014899	112	45547											
CCDC129	223075	broad.mit.edu	37	chr7	31682745	31682745	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaggcctgagggagctggCaaagtgcaaagccaccacaa	13	4	14	10	0	0	2	0	2	0	0	0	3	0	3	3	3	3	3	3	3	3	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:31682745C>A	uc003tcj.1	+	11	2754	c.1761C>A	c.(1759-1761)GGC>GGA	p.G587G	CCDC129_uc011kad.1_Silent_p.G597G|CCDC129_uc003tci.1_Silent_p.G438G|CCDC129_uc011kae.1_Silent_p.G613G|CCDC129_uc003tck.1_Silent_p.G495G	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	587											0						AGGGAGCTGGCAAAGTGCAAA	0.498													57	204					2.2129e-31	3.01589e-31	1	0	A	31682745	A	A	31682745	2	1	248	1	0	0	0	0	0	0	0	1	2776	697	25	4		4	CCDC129	7	31682745	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	558981	31682745	127455918	113	45548											
ZNF479	90827	broad.mit.edu	37	chr7	57194381	57194381	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatccaggcattgccattcCtccagagagaattctatagc	12	10	7	12	0	1	2	0	0	1	2	4	3	4	2	4	1	2	1	4	1	4	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:57194381C>A	uc010kzo.2	-	3	355	c.84G>T	c.(82-84)GAG>GAT	p.E28D		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			ATTGCCATTCCTCCAGAGAGA	0.438													30	43					1.99505e-19	2.52707e-19	1	0	A	57194381	A	A	57194381	3	1	248	1	0	0	0	0	1	0	0	0	18000	680	24	4	1502	4	ZNF479	7	57194381	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	25511636	57194381	101944282	114	45549											
SEMA3D	223117	broad.mit.edu	37	chr7	84649548	84649548	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcactctggactgagtcttaCcttgaatatctgcaactcct	9	13	7	12	0	3	2	0	2	3	0	4	3	4	3	2	1	3	2	2	1	4	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:84649548C>A	uc003uic.2	-	12	1543	c.1503_splice	c.e12+1	p.K501_splice	SEMA3D_uc010led.2_Splice_Site_p.K501_splice|SEMA3D_uc003uib.2_Splice_Site_p.K140_splice	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor						cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CTGAGTCTTACCTTGAATATC	0.413													23	43					3.65163e-15	4.41751e-15	1	0	A	84649548	A	A	84649548	5	1	248	1	0	0	0	0	0	0	1	0	14092	521	18	4	853	4	SEMA3D	7	84649548	Splice_Site	SNP	C	TCGA-CV-7409-01A-31D-2229-08	27455167	84649548	74489115	115	45550											
AKAP9	10142	broad.mit.edu	37	chr7	91630492	91630492	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcgaaactgatatagtacaaCgaatggaacaagaaacacaa	21	6	7	7	2	0	2	0	1	0	1	1	5	0	3	0	1	5	1	0	1	10	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:91630492C>A	uc003ulg.2	+	8	1486	c.1261C>A	c.(1261-1263)CGA>AGA	p.R421R	AKAP9_uc003ule.2_Silent_p.R433R|AKAP9_uc003ulf.2_Silent_p.R421R|AKAP9_uc003uli.2_Silent_p.R46R	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	433	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TATAGTACAACGAATGGAACA	0.348			T	BRAF	papillary thyroid								35	123					1.60099e-16	1.95878e-16	1	0	A	91630492	A	A	91630492	2	1	248	1	0	0	0	0	0	0	0	1	459	528	19	3		3	AKAP9	7	91630492	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	6980944	91630492	67508171	116	45551											
TECPR1	25851	broad.mit.edu	37	chr7	97874006	97874006	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgatggcgtacgtccacccCtgaaacaccaaggaaggggc	11	5	12	13	3	0	1	0	1	0	0	2	3	1	2	4	4	2	1	4	4	4	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:97874006C>G	uc003upg.2	-	5	614	c.409_splice	c.e5-1	p.G137_splice	TECPR1_uc003uph.1_Splice_Site_p.G58_splice	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1							integral to membrane	protein binding			pancreas(1)	1						ACGTCCACCCCTGAAACACCA	0.587													61	105					0	0	0	0	G	97874006	G	G	97874006	5	3	248	1	0	0	0	0	0	0	1	0	15809	695	24	4	3177	4	TECPR1	7	97874006	Splice_Site	SNP	C	TCGA-CV-7409-01A-31D-2229-08	6243514	97874006	61264657	117	45552											
MCM7	4176	broad.mit.edu	37	chr7	99697268	99697268	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcatcagcaaagagcttcgCgtagcgcctggcattctcac	9	8	11	13	3	2	1	2	0	1	1	4	1	2	1	1	2	3	5	1	2	2	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:99697268C>G	uc003usw.1	-	3	730	c.220G>C	c.(220-222)GCG>CCG	p.A74P	MCM7_uc003usv.1_5'UTR|MCM7_uc003usx.1_5'UTR|AP4M1_uc011kjg.1_5'Flank|AP4M1_uc010lgl.1_5'Flank|AP4M1_uc003utb.3_5'Flank|AP4M1_uc003utc.3_5'Flank|AP4M1_uc010lgm.2_5'Flank|AP4M1_uc003utd.2_5'Flank|AP4M1_uc011kjh.1_5'Flank|AP4M1_uc003ute.3_5'Flank|AP4M1_uc003utf.3_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	74					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	AAGAGCTTCGCGTAGCGCCTG	0.547													31	109					0	0	0	0	G	99697268	G	G	99697268	3	3	248	1	0	0	0	0	1	0	0	0	9445	768	27	3	1991	3	MCM7	7	99697268	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	1823262	99697268	59441395	118	45553											
STAG3	10734	broad.mit.edu	37	chr7	99802959	99802959	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccctgtggagaacacagcaGagaccagccctcaggtcctc	10	5	11	15	0	1	2	1	0	0	2	3	4	2	2	4	2	3	1	4	2	1	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:99802959G>A	uc003utx.1	+	29	3345	c.3190G>A	c.(3190-3192)GAG>AAG	p.E1064K	STAG3_uc011kjk.1_Missense_Mutation_p.E1006K|GATS_uc003uty.3_Intron|GATS_uc003utz.3_Intron|GATS_uc003uua.3_Intron|GATS_uc010lgt.2_Intron|STAG3_uc003uub.1_Missense_Mutation_p.E288K	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	1064					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAACACAGCAGAGACCAGCCC	0.632													39	47					0	0	0	0	A	99802959	A	A	99802959	3	1	248	1	0	0	0	0	1	0	0	0	15310	943	33	2	3300	2	STAG3	7	99802959	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	105691	99802959	59335704	119	45554											
KCND2	3751	broad.mit.edu	37	chr7	119915462	119915462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagtcgttaccgttttgtgcGtagtgtcatgagtatcatcg	7	16	11	7	4	2	1	2	1	0	0	4	1	2	1	1	0	2	4	1	0	4	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:119915462G>A	uc003vjj.1	+	1	1741	c.776G>A	c.(775-777)CGT>CAT	p.R259H		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	259	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					CGTTTTGTGCGTAGTGTCATG	0.532													10	32					0	0	0	0	A	119915462	A	A	119915462	3	1	248	1	0	0	0	0	1	0	0	0	8058	1145	40	1	778	1	KCND2	7	119915462	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	20112503	119915462	39223201	120	45555											
PLXNA4	91584	broad.mit.edu	37	chr7	131848901	131848901	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacagatgggtgggctcacCagggttttgtagtcaatctg	10	11	13	7	0	3	1	2	0	1	1	3	1	3	1	1	3	1	3	1	3	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:131848901C>A	uc003vra.3	-	24	4729	c.4500G>T	c.(4498-4500)CTG>CTT	p.L1500L		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1500	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GTGGGCTCACCAGGGTTTTGT	0.602													9	41					0.000442599	0.000452404	1	0	A	131848901	A	A	131848901	2	1	248	1	0	0	0	0	0	0	0	1	12177	608	21	4		4	PLXNA4	7	131848901	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	11933439	131848901	27289762	121	45556											
ZC3HAV1	56829	broad.mit.edu	37	chr7	138764847	138764848	+	Missense_Mutation	DNP	GC	AA	AA																															tcctccagggaagccctgtgGctgatctgatctggactagg																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:138764847_138764848GC>AA	uc003vun.2	-	4	1227_1228	c.839_840GC>TT	c.(838-840)AGC>ATT	p.S280I	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Missense_Mutation_p.S280I	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	280					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						AAGCCCTGTGGCTGATCTGATC	0.584													29	150					0	0	0	0	AA	138764848	AA	AA	138764847	3	1	248	1	0	0	0	0	1	0	0	0	17642	1194	42	4	1912	4	ZC3HAV1	7	138764847	Missense_Mutation	DNP	GC	TCGA-CV-7409-01A-31D-2229-08	6915946	138764847	20373816	122	45557											
PRSS1	5644	broad.mit.edu	37	chr7	142459789	142459789	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtgcagtaatcaacgcccGcgtgtccaccatctctctgc	8	9	8	16	4	3	0	1	0	2	0	5	0	4	0	3	0	3	2	3	0	2	1	rs77914057		TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:142459789G>T	uc003wak.2	+	3	382	c.365G>T	c.(364-366)CGC>CTC	p.R122L	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.R62L	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	122	Peptidase S1.		R -> H (in PCTT; suppresses an autocleavage site which is probably part of a fail-safe mechanism by which trypsin, which is activated within the pancreas, may be inactivated; loss of this cleavage site would permit autodigestion resulting in pancreatitis).|R -> C (in PCTT; suppresses an autocleavage site).		digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			ATCAACGCCCGCGTGTCCACC	0.577									Hereditary_Pancreatitis				43	132					1.15505e-17	1.42943e-17	1	0	T	142459789	T	T	142459789	3	4	248	1	0	0	0	0	1	0	0	0	12676	1087	38	3	375	3	PRSS1	7	142459789	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	3694942	142459789	16678874	123	45558											
OR2A12	346525	broad.mit.edu	37	chr7	143792215	143792215	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaacatggaaagcaatcaGacctggatcacagaagtcat	17	6	10	8	0	3	3	3	0	0	3	3	6	3	5	1	2	2	1	1	2	4	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:143792215G>C	uc011kty.1	+	1	15	c.15G>C	c.(13-15)CAG>CAC	p.Q5H		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					AAAGCAATCAGACCTGGATCA	0.398													18	37					0	0	0	0	C	143792215	C	C	143792215	3	2	248	1	0	0	0	0	1	0	0	0	11029	933	33	2	17	2	OR2A12	7	143792215	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	1332426	143792215	15346448	124	45559											
CNTNAP2	26047	broad.mit.edu	37	chr7	147815227	147815227	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggaattattggaatgccGcctctttcccaaacccatcc	10	10	7	14	1	1	0	0	0	1	0	3	2	3	2	5	2	2	0	5	2	4	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:147815227G>T	uc003weu.1	+	16	2917	c.2401G>T	c.(2401-2403)GCC>TCC	p.A801S		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	801	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTGGAATGCCGCCTCTTTCCC	0.443										HNSCC(39;0.1)			58	87					8.73484e-25	1.12854e-24	1	0	T	147815227	T	T	147815227	3	4	248	1	0	0	0	0	1	0	0	0	3662	1087	38	3	2463	3	CNTNAP2	7	147815227	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	4023012	147815227	11323436	125	45560											
REPIN1	29803	broad.mit.edu	37	chr7	150069096	150069096	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaacttgatcgctcaccgcCgcgtgcacacgggcgagcgg	7	5	13	16	7	1	1	1	1	0	0	2	2	1	1	3	2	3	2	3	2	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr7:150069096C>T	uc010lpq.1	+	4	1255	c.766C>T	c.(766-768)CGC>TGC	p.R256C	REPIN1_uc003whd.2_Missense_Mutation_p.R245C|REPIN1_uc010lpr.1_Missense_Mutation_p.R313C|REPIN1_uc003whc.2_Missense_Mutation_p.R256C|REPIN1_uc003whe.2_Missense_Mutation_p.R256C	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	256	C2H2-type 6.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CGCTCACCGCCGCGTGCACAC	0.597													20	65					0	0	0	0	T	150069096	T	T	150069096	3	4	248	1	0	0	0	0	1	0	0	0	13292	652	23	1	943	1	REPIN1	7	150069096	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	2253869	150069096	9069567	126	45561											
RP1L1	94137	broad.mit.edu	37	chr8	10467869	10467869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttggttttccagatcccctgGgctctcataagttcttgaat	7	16	8	10	0	2	2	1	1	2	1	5	2	4	2	3	2	0	3	3	2	2	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:10467869G>A	uc003wtc.2	-	4	3968	c.3739C>T	c.(3739-3741)CCA>TCA	p.P1247S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1247					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGATCCCCTGGGCTCTCATAA	0.552													14	35					0	0	0	0	A	10467869	A	A	10467869	3	1	248	1	0	0	0	0	1	0	0	0	13598	1232	43	4	3467	4	RP1L1	8	10467869	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08		10467869	135896153	127	45562											
HR	55806	broad.mit.edu	37	chr8	21986565	21986565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggctctcccaggcacagcGgcccatggtgcagtccatct	7	7	11	16	1	2	0	0	0	2	0	4	0	3	0	3	4	2	3	3	4	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:21986565G>A	uc003xas.2	-	2	784	c.119C>T	c.(118-120)CCG>CTG	p.P40L	HR_uc003xat.2_Missense_Mutation_p.P40L|HR_uc010lts.2_Missense_Mutation_p.P40L	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	40							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CAGGCACAGCGGCCCATGGTG	0.672													15	62					0	0	0	0	A	21986565	A	A	21986565	3	1	248	1	0	0	0	0	1	0	0	0	7386	1116	39	1	3522	1	HR	8	21986565	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	11518696	21986565	124377457	128	45563											
ADAM28	10863	broad.mit.edu	37	chr8	24167434	24167434	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgaaactgaattaaagtatAaaatgacaattaatggaaaa	22	11	6	2	0	0	3	0	3	0	0	0	4	0	4	0	1	1	1	0	1	11	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:24167434A>T	uc003xdy.2	+	3	261	c.178A>T	c.(178-180)AAA>TAA	p.K60*	ADAM28_uc003xdx.2_Nonsense_Mutation_p.K60*|ADAM28_uc011kzz.1_5'UTR|ADAM28_uc011laa.1_RNA	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	60					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		ATTAAAGTATAAAATGACAAT	0.274													7	32					0	0	0	0	T	24167434	T	T	24167434	4	4	248	1	0	0	0	0	0	1	0	0	246	363	13	5	188	5	ADAM28	8	24167434	Nonsense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	2180869	24167434	122196588	129	45564											
DPYSL2	1808	broad.mit.edu	37	chr8	26509930	26509930	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttccctgattttgtttacaAgcgtatcaaggcaaggagca	11	12	9	9	1	1	1	1	1	0	0	2	2	2	2	1	2	3	4	1	2	5	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:26509930A>T	uc003xfb.1	+	12	1789	c.1439A>T	c.(1438-1440)AAG>ATG	p.K480M	DPYSL2_uc003xfa.2_Missense_Mutation_p.K585M|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Missense_Mutation_p.K444M	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	480					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		TTTGTTTACAAGCGTATCAAG	0.433													18	50					0	0	0	0	T	26509930	T	T	26509930	3	4	248	1	0	0	0	0	1	0	0	0	4769	72	3	5	1485	5	DPYSL2	8	26509930	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	2342496	26509930	119854092	130	45565											
KCNU1	157855	broad.mit.edu	37	chr8	36793341	36793341	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacaaacagtattatatcatCtcagatacctttaggtgaca	16	12	5	8	0	2	2	2	1	1	1	3	2	2	2	1	1	3	1	1	1	7	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:36793341C>T	uc010lvw.2	+	27	3440	c.3353C>T	c.(3352-3354)TCT>TTT	p.S1118F		NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	1118	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ATTATATCATCTCAGATACCT	0.378													16	47					0	0	0	0	T	36793341	T	T	36793341	3	4	248	1	0	0	0	0	1	0	0	0	8132	913	32	2	3459	2	KCNU1	8	36793341	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	10283411	36793341	109570681	131	45566											
ADAM18	8749	broad.mit.edu	37	chr8	39525676	39525676	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgctataacggacaatgtCaaactactgataaccagtgt	15	11	7	8	1	1	1	1	1	0	0	1	2	1	2	1	1	5	1	1	1	6	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:39525676C>A	uc003xni.2	+	14	1486	c.1486C>A	c.(1486-1488)CAA>AAA	p.Q496K	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.Q472K	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	496	Cys-rich.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CGGACAATGTCAAACTACTGA	0.383													26	113					6.38683e-12	7.47444e-12	1	0	A	39525676	A	A	39525676	3	1	248	1	0	0	0	0	1	0	0	0	239	827	29	2	1540	2	ADAM18	8	39525676	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	2732335	39525676	106838346	132	45567											
ZFHX4	79776	broad.mit.edu	37	chr8	77764404	77764405	+	Frame_Shift_Ins	INS	-	T	T																															tacctgggacggagttcagcINSttggggccagatttgggctt																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:77764404_77764405insT	uc003yav.2	+	10	5499_5500	c.5112_5113insT	c.(5110-5115)AGCTTGfs	p.S1704fs	ZFHX4_uc003yau.1_Frame_Shift_Ins_p.S1749fs|ZFHX4_uc003yaw.1_Frame_Shift_Ins_p.S1704fs	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1704_1705	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CGGAGTTCAGCTTGGGGCCAGA	0.51										HNSCC(33;0.089)			---	---	---								T	77764405	T	T	77764404	7	5	248	1	0	1	1	0	0	0	0	0	17702	796	28	0	5281	0	ZFHX4	8	77764404	Frame_Shift_Ins	INS	-	TCGA-CV-7409-01A-31D-2229-08	38238728	77764404	68599618	133	45568											
RNF19A	25897	broad.mit.edu	37	chr8	101300161	101300161	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccgccatttagctcccttGatttacgtttgttatctttt	5	19	5	12	2	1	1	0	1	1	0	2	1	2	1	4	0	2	3	4	0	3	9			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:101300161G>C	uc003yjj.1	-	3	559	c.242C>G	c.(241-243)TCA>TGA	p.S81*	RNF19A_uc003yjk.1_Nonsense_Mutation_p.S81*|RNF19A_uc003yjl.1_Nonsense_Mutation_p.S81*	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	81					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			TAGCTCCCTTGATTTACGTTT	0.388													175	103					0	0	0	0	C	101300161	C	C	101300161	4	2	248	1	0	0	0	0	0	1	0	0	13535	1294	45	2	2310	2	RNF19A	8	101300161	Nonsense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	23535757	101300161	45063861	134	45569											
RIMS2	9699	broad.mit.edu	37	chr8	105010427	105010427	+	Frame_Shift_Del	DEL	T	-	-																															ttgcagtcattttcttactcTacctcgctccagatacagtc																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:105010427delT	uc003yls.2	+	16	2634	c.2393delT	c.(2392-2394)CTAfs	p.L798fs	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Frame_Shift_Del_p.L812fs|RIMS2_uc003ylq.2_Frame_Shift_Del_p.L812fs|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TTTCTTACTCTACCTCGCTCC	0.353										HNSCC(12;0.0054)			---	---	---								-	105010427	-	-	105010427	7	5	248	1	0	1	0	1	0	0	0	0	13433	1522	53	0	3255	0	RIMS2	8	105010427	Frame_Shift_Del	DEL	T	TCGA-CV-7409-01A-31D-2229-08	3710266	105010427	41353595	135	45570											
ANGPT1	284	broad.mit.edu	37	chr8	108334194	108334194	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccagttgctgcttctgaagGacactgttgttggtggtagc	6	14	13	8	0	1	1	0	1	1	0	2	2	2	2	1	3	3	6	1	3	2	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:108334194G>T	uc003ymn.2	-	4	1206	c.738C>A	c.(736-738)GTC>GTA	p.V246V	ANGPT1_uc011lhv.1_Silent_p.V46V|ANGPT1_uc003ymo.2_Silent_p.V246V|ANGPT1_uc003ymp.3_Silent_p.V46V	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	246	Potential.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			GCTTCTGAAGGACACTGTTGT	0.428													75	102					6.11987e-43	8.98509e-43	1	0	T	108334194	T	T	108334194	2	4	248	1	0	0	0	0	0	0	0	1	610	1161	41	2		2	ANGPT1	8	108334194	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	3323767	108334194	38029828	136	45571											
CSMD3	114788	broad.mit.edu	37	chr8	113246666	113246666	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaggtactttaataagataTatgcgtaacattaggcgagc	14	11	10	6	2	0	1	0	0	0	1	0	2	0	1	0	2	4	3	0	2	7	8			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:113246666T>C	uc003ynu.2	-	68	10827	c.10668A>G	c.(10666-10668)ATA>ATG	p.I3556M	CSMD3_uc003yns.2_Missense_Mutation_p.I2758M|CSMD3_uc003ynt.2_Missense_Mutation_p.I3516M|CSMD3_uc011lhx.1_Missense_Mutation_p.I3387M	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3556	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAATAAGATATATGCGTAACA	0.333										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			112	69					0	0	0	0	C	113246666	C	C	113246666	3	2	248	1	0	0	0	0	1	0	0	0	3963	1396	49	5	471	5	CSMD3	8	113246666	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	4912472	113246666	33117356	137	45572											
PLEC	5339	broad.mit.edu	37	chr8	144995795	144995795	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaagcctgaggccgcctgcgCctccagcaggatgagggccg	7	4	16	14	3	0	2	0	2	0	0	1	4	1	3	6	3	3	1	6	3	1	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:144995795C>A	uc003zaf.1	-	32	8775	c.8605G>T	c.(8605-8607)GCG>TCG	p.A2869S	PLEC_uc003zab.1_Missense_Mutation_p.A2732S|PLEC_uc003zac.1_Missense_Mutation_p.A2736S|PLEC_uc003zad.2_Missense_Mutation_p.A2732S|PLEC_uc003zae.1_Missense_Mutation_p.A2700S|PLEC_uc003zag.1_Missense_Mutation_p.A2710S|PLEC_uc003zah.2_Missense_Mutation_p.A2718S|PLEC_uc003zaj.2_Missense_Mutation_p.A2759S	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2869	Globular 2.|Plectin 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCGCCTGCGCCTCCAGCAGG	0.672													57	55					2.73381e-35	3.87289e-35	1	0	A	144995795	A	A	144995795	3	1	248	1	0	0	0	0	1	0	0	0	12107	739	26	4	5453	4	PLEC	8	144995795	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	31749129	144995795	1368227	138	45573											
PLEC	5339	broad.mit.edu	37	chr8	144998152	144998152	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcctcagcctcacggcgcCgccgctcctcctccgccgcc	2	6	9	24	6	2	0	2	0	0	0	6	0	6	0	9	1	1	2	9	1	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr8:144998152C>A	uc003zaf.1	-	31	6526	c.6356G>T	c.(6355-6357)CGG>CTG	p.R2119L	PLEC_uc003zab.1_Missense_Mutation_p.R1982L|PLEC_uc003zac.1_Missense_Mutation_p.R1986L|PLEC_uc003zad.2_Missense_Mutation_p.R1982L|PLEC_uc003zae.1_Missense_Mutation_p.R1950L|PLEC_uc003zag.1_Missense_Mutation_p.R1960L|PLEC_uc003zah.2_Missense_Mutation_p.R1968L|PLEC_uc003zaj.2_Missense_Mutation_p.R2009L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2119	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTCACGGCGCCGCCGCTCCTC	0.731													24	14					4.7796e-09	5.45517e-09	1	0	A	144998152	A	A	144998152	3	1	248	1	0	0	0	0	1	0	0	0	12107	652	23	3	7706	3	PLEC	8	144998152	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	2357	144998152	1365870	139	45574											
IFNA4	3441	broad.mit.edu	37	chr9	21187529	21187529	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaagaaaaggacagggccAttgggatgttgcaaatattg	15	9	13	4	0	0	1	0	0	0	1	0	3	0	3	1	3	1	3	1	3	6	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:21187529A>G	uc003zon.2	-	1	70	c.2T>C	c.(1-3)ATG>ACG	p.M1T		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	1					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GGACAGGGCCATTGGGATGTT	0.473													27	17					0	0	0	0	G	21187529	G	G	21187529	3	3	248	1	0	0	0	0	1	0	0	0	7578	217	8	5	571	5	IFNA4	9	21187529	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08		21187529	120025902	140	45575											
MTAP	4507	broad.mit.edu	37	chr9	21854825	21854825	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatttgttacgcaagtatcGccatggcgacagattatgac	12	11	10	8	3	0	2	0	1	0	1	1	4	0	2	1	1	1	3	1	1	5	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:21854825G>A	uc003zph.2	+	6	759	c.646G>A	c.(646-648)GCC>ACC	p.A216T	MTAP_uc003zpi.1_Intron|MTAP_uc010mit.2_RNA|MTAP_uc011lnk.1_Missense_Mutation_p.A233T|MTAP_uc011lnl.1_Missense_Mutation_p.A149T	NM_002451	NP_002442	Q13126	MTAP_HUMAN	5'-methylthioadenosine phosphorylase	216					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity			central_nervous_system(1)	1		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	CGCAAGTATCGCCATGGCGAC	0.498													21	63					0	0	0	0	A	21854825	A	A	21854825	3	1	248	1	0	0	0	0	1	0	0	0	9964	1087	38	1	668	1	MTAP	9	21854825	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	667296	21854825	119358606	141	45576											
CDKN2A	1029	broad.mit.edu	37	chr9	21971000	21971000	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacatcgcgatggcccagctCctcagccaggtccacgggca	8	5	12	16	3	1	0	1	0	0	0	4	2	3	0	4	3	2	2	4	3	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:21971000C>A	uc003zpk.2	-	2	570	c.358G>T	c.(358-360)GAG>TAG	p.E120*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	120	ANK 4.		E -> A (in non-small cell lung carcinoma).|E -> K (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E120*(8)|p.E120K(4)|p.E120A(1)|p.A118fs*10(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGGCCCAGCTCCTCAGCCAGG	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			57	29					6.20943e-19	7.83456e-19	1	0	A	21971000	A	A	21971000	4	1	248	1	0	0	0	0	0	1	0	0	3176	864	30	2	120	2	CDKN2A	9	21971000	Nonsense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	116175	21971000	119242431	142	45577											
PCSK5	5125	broad.mit.edu	37	chr9	78710973	78710973	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggaagagtgttcatccacGctggccacaacctacagcag	11	7	10	13	1	1	1	1	0	0	1	2	2	2	2	3	2	3	3	3	2	3	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:78710973G>T	uc004ajz.2	+	8	1600	c.1062G>T	c.(1060-1062)ACG>ACT	p.T354T	PCSK5_uc004ajy.2_Silent_p.T354T|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	354	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						GTTCATCCACGCTGGCCACAA	0.478													30	45					2.20262e-25	2.86874e-25	1	0	T	78710973	T	T	78710973	2	4	248	1	0	0	0	0	0	0	0	1	11657	1074	38	3		3	PCSK5	9	78710973	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	56739973	78710973	62502458	143	45578											
PRUNE2	158471	broad.mit.edu	37	chr9	79320143	79320143	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acatcatattcaaaatcaccCcacgaggcttcagatgagca	15	8	6	12	1	4	2	4	1	0	1	4	3	4	2	2	1	1	2	2	1	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:79320143C>A	uc010mpk.2	-	8	7171	c.7047G>T	c.(7045-7047)TGG>TGT	p.W2349C	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2349					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CAAAATCACCCCACGAGGCTT	0.468													100	134					1.73885e-55	2.62452e-55	1	0	A	79320143	A	A	79320143	3	1	248	1	0	0	0	0	1	0	0	0	12703	624	22	4	2267	4	PRUNE2	9	79320143	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	609170	79320143	61893288	144	45579											
PRUNE2	158471	broad.mit.edu	37	chr9	79324702	79324702	+	Frame_Shift_Del	DEL	C	-	-																															catggcccactcattcgggtCcctaacagaaggtgtcttgc																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:79324702delC	uc010mpk.2	-	8	2612	c.2488delG	c.(2488-2490)GACfs	p.D830fs		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	830					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TCATTCGGGTCCCTAACAGAA	0.443													---	---	---								-	79324702	-	-	79324702	7	5	248	1	0	1	0	1	0	0	0	0	12703	855	30	0	6826	0	PRUNE2	9	79324702	Frame_Shift_Del	DEL	C	TCGA-CV-7409-01A-31D-2229-08	4559	79324702	61888729	145	45580											
FAM75C1	441452	broad.mit.edu	37	chr9	90536468	90536468	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agggaaggttctgggggcgaCctctgaggagtcagaaagga	11	6	18	6	1	3	2	1	1	2	1	3	6	3	5	1	6	0	1	1	6	2	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:90536468C>A	uc010mqi.2	+	4	1675	c.1646C>A	c.(1645-1647)ACC>AAC	p.T549N	FAM75C1_uc004apq.3_Missense_Mutation_p.T532N	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						CTGGGGGCGACCTCTGAGGAG	0.517													78	58					1.53041e-28	2.05113e-28	1	0	A	90536468	A	A	90536468	3	1	248	1	0	0	0	0	1	0	0	0	5655	507	18	4	1660	4	FAM75C1	9	90536468	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	11211766	90536468	50676963	146	45581											
OR13C2	392376	broad.mit.edu	37	chr9	107367223	107367223	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcttctcccctcggaagagCtaattttgaagatgctcaca	10	12	8	11	1	2	3	1	1	1	2	4	4	2	4	2	1	3	3	2	1	3	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:107367223C>A	uc011lvq.1	-	1	686	c.686G>T	c.(685-687)AGC>ATC	p.S229I		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTCGGAAGAGCTAATTTTGAA	0.418													78	150					3.80207e-26	4.99215e-26	1	0	A	107367223	A	A	107367223	3	1	248	1	0	0	0	0	1	0	0	0	10988	797	28	4	273	4	OR13C2	9	107367223	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	16830755	107367223	33846208	147	45582											
SVEP1	79987	broad.mit.edu	37	chr9	113228230	113228230	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctccgggaaccaaatttTggctgataagtgcccagtgg	10	9	12	10	1	0	1	0	1	0	0	1	2	1	2	3	3	3	2	3	3	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:113228230T>A	uc010mtz.2	-	18	3574	c.3237A>T	c.(3235-3237)CCA>CCT	p.P1079P	SVEP1_uc010mua.1_Silent_p.P1079P	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1079					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AACCAAATTTTGGCTGATAAG	0.448													15	31					0	0	0	0	A	113228230	A	A	113228230	2	1	248	1	0	0	0	0	0	0	0	1	15486	1799	63	5		5	SVEP1	9	113228230	Silent	SNP	T	TCGA-CV-7409-01A-31D-2229-08	5861007	113228230	27985201	148	45583											
DAB2IP	153090	broad.mit.edu	37	chr9	124528979	124528979	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caccctcaccctcatcgccaAggtcacccagaacctggcca	10	5	6	20	1	3	1	3	0	0	1	4	1	3	1	6	2	1	0	6	2	2	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:124528979A>C	uc004bln.2	+	9	1652	c.1583A>C	c.(1582-1584)AAG>ACG	p.K528T	DAB2IP_uc004blo.2_Missense_Mutation_p.K432T|DAB2IP_uc004blp.2_5'Flank	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	556	Ras-GAP.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						CTCATCGCCAAGGTCACCCAG	0.637													201	259					0	0	0	0	C	124528979	C	C	124528979	3	2	248	1	0	0	0	0	1	0	0	0	4236	72	3	5	1617	5	DAB2IP	9	124528979	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	11300749	124528979	16684452	149	45584											
TSC1	7248	broad.mit.edu	37	chr9	135778029	135778047	+	Frame_Shift_Del	DEL	TCATGCTGCAGCTGTCTGA	-	-																															ggttgtagaattcctctcggTcatgctgcagctgtctgatc																								rs118203681		TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr9:135778029_135778047delTCATGCTGCAGCTGTCTGA	uc004cca.2	-	18	2570_2588	c.2336_2354delTCAGACAGCTGCAGCATGA	c.(2335-2355)ATCAGACAGCTGCAGCATGACfs	p.I779fs	TSC1_uc004ccb.3_Frame_Shift_Del_p.I778fs|TSC1_uc011mcq.1_Frame_Shift_Del_p.I728fs|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	779_785	Potential.				activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TTCCTCTCGGTCATGCTGCAGCTGTCTGATCTGGCTGTG	0.521			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis		OREG0019577	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	135778047	-	-	135778029	7	5	248	1	0	1	0	1	0	0	0	0	16672	1667	58	0	1164	0	TSC1	9	135778029	Frame_Shift_Del	DEL	TCATGCTGCAGCTGTCTGA	TCGA-CV-7409-01A-31D-2229-08	11249050	135778029	5435402	150	45585											
PFKP	5214	broad.mit.edu	37	chr10	3146081	3146081	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgaccatcggcacggacTccgccctgcacaggatcatc	10	6	9	16	3	1	1	1	1	0	0	4	3	2	3	3	3	1	2	3	3	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr10:3146081T>C	uc001igp.2	+	5	601	c.565T>C	c.(565-567)TCC>CCC	p.S189P	PFKP_uc001igq.2_Missense_Mutation_p.S181P|PFKP_uc009xhr.2_Missense_Mutation_p.S151P|PFKP_uc009xhs.1_5'Flank	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	189					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		CGGCACGGACTCCGCCCTGCA	0.632													11	56					0	0	0	0	C	3146081	C	C	3146081	3	2	248	1	0	0	0	0	1	0	0	0	11821	1551	54	5	583	5	PFKP	10	3146081	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08		3146081	132388666	151	45586											
SLC39A12	221074	broad.mit.edu	37	chr10	18250514	18250514	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgttttcttccacagtgctTtgaaccagatgcactattac	9	16	6	10	0	1	2	0	1	1	1	2	2	2	2	2	0	4	3	2	0	3	7			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr10:18250514T>A	uc001ipo.2	+	3	539	c.266T>A	c.(265-267)TTT>TAT	p.F89Y	SLC39A12_uc001ipn.2_Missense_Mutation_p.F89Y|SLC39A12_uc001ipp.2_Missense_Mutation_p.F89Y|SLC39A12_uc010qck.1_Translation_Start_Site	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	89	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						CCACAGTGCTTTGAACCAGAT	0.368													9	29					0	0	0	0	A	18250514	A	A	18250514	3	1	248	1	0	0	0	0	1	0	0	0	14679	1841	64	5	272	5	SLC39A12	10	18250514	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	15104433	18250514	117284233	152	45587											
ARMC4	55130	broad.mit.edu	37	chr10	28101547	28101547	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggggacccaaccatatccAgtagaagctgtcacacataa	15	6	8	12	0	1	1	1	0	0	1	2	2	2	2	3	2	2	2	3	2	5	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr10:28101547A>T	uc009xky.2	-	20	3127	c.3029T>A	c.(3028-3030)CTG>CAG	p.L1010Q	ARMC4_uc010qds.1_Missense_Mutation_p.W576R|ARMC4_uc010qdt.1_Missense_Mutation_p.L702Q|ARMC4_uc001itz.2_Missense_Mutation_p.L1010Q	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	1010	ARM 10.						binding			ovary(4)|skin(2)	6						AACCATATCCAGTAGAAGCTG	0.423													22	39					0	0	0	0	T	28101547	T	T	28101547	3	4	248	1	0	0	0	0	1	0	0	0	955	188	7	5	109	5	ARMC4	10	28101547	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	9851033	28101547	107433200	153	45588											
LRRTM3	347731	broad.mit.edu	37	chr10	68687344	68687344	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccaagctcaacctggccCtttttccaaggttggtcagc	7	13	8	13	0	2	0	2	0	0	0	4	0	4	0	4	3	3	2	4	3	3	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr10:68687344C>T	uc001jmz.1	+	2	1220	c.670C>T	c.(670-672)CTT>TTT	p.L224F	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.L224F	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	224	Extracellular (Potential).|LRR 7.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CAACCTGGCCCTTTTTCCAAG	0.463													39	60					0	0	0	0	T	68687344	T	T	68687344	3	4	248	1	0	0	0	0	1	0	0	0	9091	681	24	4	676	4	LRRTM3	10	68687344	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	40585797	68687344	66847403	154	45589											
KIAA1274	27143	broad.mit.edu	37	chr10	72300939	72300939	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgtgttcagctgcctcagcGgccagggccgtaccacaact	7	8	11	15	3	2	0	2	0	0	0	3	0	2	0	4	2	5	3	4	2	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr10:72300939G>A	uc001jrd.3	+	16	2271	c.1990G>A	c.(1990-1992)GGC>AGC	p.G664S	KIAA1274_uc001jre.3_5'UTR	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	664										ovary(2)|central_nervous_system(1)	3						CTGCCTCAGCGGCCAGGGCCG	0.607													23	92					0	0	0	0	A	72300939	A	A	72300939	3	1	248	1	0	0	0	0	1	0	0	0	8259	1116	39	1	2048	1	KIAA1274	10	72300939	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	3613595	72300939	63233808	155	45590											
TTC18	118491	broad.mit.edu	37	chr10	75072315	75072315	+	Frame_Shift_Del	DEL	G	-	-																															ttcttagaaacagcttgtttGgacagcagagaattaattcc																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr10:75072315delG	uc009xrc.2	-	11	1330	c.1209delC	c.(1207-1209)TCCfs	p.S403fs	TTC18_uc001jty.2_Frame_Shift_Del_p.S403fs|TTC18_uc009xrd.1_Frame_Shift_Del_p.S211fs	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	403							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					CAGCTTGTTTGGACAGCAGAG	0.373													---	---	---								-	75072315	-	-	75072315	7	5	248	1	0	1	0	1	0	0	0	0	16753	1335	47	0	2228	0	TTC18	10	75072315	Frame_Shift_Del	DEL	G	TCGA-CV-7409-01A-31D-2229-08	2771376	75072315	60462432	156	45591											
ZNF518A	9849	broad.mit.edu	37	chr10	97916239	97916239	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgtgaaaattgatttgccaAaaataaatattccaaatgaa	20	12	5	4	0	0	3	0	3	0	0	1	3	1	3	2	0	1	0	2	0	9	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr10:97916239A>C	uc001klp.2	+	6	1017	c.160A>C	c.(160-162)AAA>CAA	p.K54Q	ZNF518A_uc001klo.1_Intron|ZNF518A_uc001klq.2_Missense_Mutation_p.K54Q|ZNF518A_uc001klr.2_Missense_Mutation_p.K54Q	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TGATTTGCCAAAAATAAATAT	0.294													21	16					0	0	0	0	C	97916239	C	C	97916239	3	2	248	1	0	0	0	0	1	0	0	0	18029	15	1	5	162	5	ZNF518A	10	97916239	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	22843924	97916239	37618508	157	45592											
ZDHHC16	84287	broad.mit.edu	37	chr10	99213336	99213336	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaccatcggtacttcttctcTttctgctttttcatgactct	6	19	4	12	1	5	1	1	1	4	0	7	1	5	1	1	1	3	2	1	1	2	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr10:99213336T>C	uc001knj.2	+	7	955	c.606T>C	c.(604-606)TCT>TCC	p.S202S	ZDHHC16_uc001knp.2_Intron|ZDHHC16_uc001knk.2_Silent_p.S202S|ZDHHC16_uc001knl.2_Silent_p.S202S|ZDHHC16_uc001knm.2_Silent_p.S137S|ZDHHC16_uc001knn.2_Intron|ZDHHC16_uc010qow.1_Silent_p.S202S|ZDHHC16_uc009xvq.2_RNA|ZDHHC16_uc001kno.2_Silent_p.S202S|ZDHHC16_uc009xvr.2_Silent_p.S202S	NM_198046	NP_932163	Q969W1	ZDH16_HUMAN	Abl-philin 2 isoform 1	202	DHHC-type.|Helical; (Potential).				apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		ACTTCTTCTCTTTCTGCTTTT	0.468													65	113					0	0	0	0	C	99213336	C	C	99213336	2	2	248	1	0	0	0	0	0	0	0	1	17673	1596	56	5		5	ZDHHC16	10	99213336	Silent	SNP	T	TCGA-CV-7409-01A-31D-2229-08	1297097	99213336	36321411	158	45593											
GFRA1	2674	broad.mit.edu	37	chr10	117849305	117849305	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaatttcattctcagaccCtgctggccccaggggcttgt	6	11	12	12	0	2	1	2	0	1	1	3	2	2	2	3	4	1	2	3	4	1	3	rs77098230		TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr10:117849305C>A	uc001lcj.2	-	9	1842	c.1144G>T	c.(1144-1146)GGG>TGG	p.G382W	GFRA1_uc001lci.2_Missense_Mutation_p.G377W|GFRA1_uc009xyr.2_Missense_Mutation_p.G377W	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	382					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TTCTCAGACCCTGCTGGCCCC	0.577													75	99					5.88917e-42	8.49197e-42	1	0	A	117849305	A	A	117849305	3	1	248	1	0	0	0	0	1	0	0	0	6384	681	24	4	265	4	GFRA1	10	117849305	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	18635969	117849305	17685442	159	45594											
CPXM2	119587	broad.mit.edu	37	chr10	125539756	125539756	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatctcgttccggcggtgaTaataattattaggatctagg	10	14	10	7	3	3	1	1	1	2	0	5	2	4	2	1	4	0	1	1	4	5	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr10:125539756T>C	uc001lhk.1	-	7	1230	c.905A>G	c.(904-906)TAT>TGT	p.Y302C	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	302					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CCGGCGGTGATAATAATTATT	0.453													42	61					0	0	0	0	C	125539756	C	C	125539756	3	2	248	1	0	0	0	0	1	0	0	0	3853	1406	49	5	1397	5	CPXM2	10	125539756	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	7690451	125539756	9994991	160	45595											
PKP3	11187	broad.mit.edu	37	chr11	396883	396883	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgctccgccgtggatctgAgctgcagtcggaggctgagt	5	8	15	13	4	1	2	0	2	1	0	3	4	2	4	3	3	2	4	3	3	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:396883A>T	uc001lpc.2	+	3	458	c.382A>T	c.(382-384)AGC>TGC	p.S128C		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	128					cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGTGGATCTGAGCTGCAGTCG	0.726													10	21					0	0	0	0	T	396883	T	T	396883	3	4	248	1	0	0	0	0	1	0	0	0	12041	304	11	5	392	5	PKP3	11	396883	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08		396883	134609633	161	45596											
LRDD	55367	broad.mit.edu	37	chr11	800406	800406	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccttcacattcttcaggtgcGagtagaagacaaagcagatt	13	10	9	9	1	3	3	2	0	1	3	3	4	3	3	1	1	2	2	1	1	3	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:800406G>A	uc001lro.1	-	13	2229	c.2087C>T	c.(2086-2088)TCG>TTG	p.S696L	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.S696L|LRDD_uc001lrl.1_Missense_Mutation_p.S539L|LRDD_uc001lrm.1_Missense_Mutation_p.S383L|LRDD_uc001lrn.1_Missense_Mutation_p.S539L|LRDD_uc001lrp.1_Missense_Mutation_p.S358L	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	696					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTTCAGGTGCGAGTAGAAGAC	0.637													34	85					0	0	0	0	A	800406	A	A	800406	3	1	248	1	0	0	0	0	1	0	0	0	8986	1059	37	1	661	1	LRDD	11	800406	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	403523	800406	134206110	162	45597											
MUC5B	727897	broad.mit.edu	37	chr11	1268755	1268755	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccacacccagcaagaccCgcacctcgaccctgctgccc	9	3	7	22	2	0	1	0	0	0	1	1	2	0	1	6	0	4	3	6	0	1	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:1268755C>A	uc009ycr.1	+	50	12355	c.12229C>A	c.(12229-12231)CGC>AGC	p.R4077S	MUC5B_uc001ltb.2_Missense_Mutation_p.R3552S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3549	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CAGCAAGACCCGCACCTCGAC	0.687													61	166					2.56221e-42	3.71119e-42	1	0	A	1268755	A	A	1268755	3	1	248	1	0	0	0	0	1	0	0	0	10032	652	23	3	10776	3	MUC5B	11	1268755	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	468349	1268755	133737761	163	45598											
OR52A5	390054	broad.mit.edu	37	chr11	5153280	5153280	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaataggccatatatcttgTtgactcggatatcttcagta	12	14	7	8	1	3	1	1	1	2	0	4	2	3	2	1	2	0	2	1	2	6	8			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:5153280T>C	uc010qyx.1	-	1	593	c.593A>G	c.(592-594)AAC>AGC	p.N198S		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	198	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATATATCTTGTTGACTCGGAT	0.398													58	80					0	0	0	0	C	5153280	C	C	5153280	3	2	248	1	0	0	0	0	1	0	0	0	11164	1725	60	5	360	5	OR52A5	11	5153280	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	3884525	5153280	129853236	164	45599											
OR52A1	23538	broad.mit.edu	37	chr11	5173436	5173437	+	Missense_Mutation	DNP	CG	GA	GA																															acaagggctcatggagactgCgctcagatttgatgatgctc																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:5173436_5173437CG>GA	uc010qyy.1	-	1	163_164	c.163_164CG>TC	c.(163-165)CGC>TCC	p.R55S		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGGAGACTGCGCTCAGATTTG	0.446													18	42					0	0	0	0	GA	5173437	GA	GA	5173436	3	3	248	1	0	0	0	0	1	0	0	0	11162	768	27	3	776	3	OR52A1	11	5173436	Missense_Mutation	DNP	CG	TCGA-CV-7409-01A-31D-2229-08	20156	5173436	129833080	165	45600											
NLRP14	338323	broad.mit.edu	37	chr11	7064949	7064949	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaaagttacttcagtgtatGgaagtattaggaaacagtga	15	12	10	4	0	2	1	2	1	0	0	2	3	2	3	0	2	2	3	0	2	7	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:7064949G>T	uc001mfb.1	+	4	2015	c.1692G>T	c.(1690-1692)ATG>ATT	p.M564I		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	564					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TTCAGTGTATGGAAGTATTAG	0.368													11	42					9.31168e-06	9.86122e-06	1	0	T	7064949	T	T	7064949	3	4	248	1	0	0	0	0	1	0	0	0	10530	1348	47	4	1702	4	NLRP14	11	7064949	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	1891513	7064949	127941567	166	45601											
SLC17A6	57084	broad.mit.edu	37	chr11	22396327	22396327	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctatctgctgtgccacaCttagtaatgacaattattgt	11	15	7	8	0	1	1	0	1	1	0	1	1	1	1	1	0	3	3	1	0	5	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:22396327C>A	uc001mqk.2	+	9	1481	c.1068C>A	c.(1066-1068)CAC>CAA	p.H356Q		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	356	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						CTGTGCCACACTTAGTAATGA	0.363													66	203					2.64105e-45	3.89525e-45	1	0	A	22396327	A	A	22396327	3	1	248	1	0	0	0	0	1	0	0	0	14486	564	20	4	1102	4	SLC17A6	11	22396327	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	15331378	22396327	112610189	167	45602											
ELP4	26610	broad.mit.edu	37	chr11	31531491	31531491	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtccattgcgggcacgcgaCcgtcggtgcggaatggacag	7	7	16	11	6	0	0	0	0	0	0	2	3	1	2	2	4	2	1	2	4	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:31531491C>T	uc001mtb.2	+	1	195	c.160C>T	c.(160-162)CCG>TCG	p.P54S	IMMP1L_uc001msy.1_5'Flank|IMMP1L_uc001msz.1_5'Flank|ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Missense_Mutation_p.P54S|ELP4_uc010rdz.1_Missense_Mutation_p.P54S|IMMP1L_uc009yjo.2_5'Flank|IMMP1L_uc009yjp.2_5'Flank	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	54					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					GGGCACGCGACCGTCGGTGCG	0.637													33	123					0	0	0	0	T	31531491	T	T	31531491	3	4	248	1	0	0	0	0	1	0	0	0	5106	507	18	4	162	4	ELP4	11	31531491	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	9135164	31531491	103475025	168	45603											
LRRC4C	57689	broad.mit.edu	37	chr11	40137050	40137050	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccactagtgactgaaggtTgtcaaaggcattccgttcaa	11	11	9	10	1	2	2	2	2	0	0	4	2	4	2	2	2	0	3	2	2	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:40137050T>G	uc001mxa.1	-	2	2757	c.793A>C	c.(793-795)AAC>CAC	p.N265H	LRRC4C_uc001mxc.1_Missense_Mutation_p.N261H|LRRC4C_uc001mxd.1_Missense_Mutation_p.N261H|LRRC4C_uc001mxb.1_Missense_Mutation_p.N261H	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	265	LRR 8.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GACTGAAGGTTGTCAAAGGCA	0.453													67	138					0	0	0	0	G	40137050	G	G	40137050	3	3	248	1	0	0	0	0	1	0	0	0	9058	1812	63	5	1133	5	LRRC4C	11	40137050	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	8605559	40137050	94869466	169	45604											
HSD17B12	51144	broad.mit.edu	37	chr11	43876270	43876270	+	Frame_Shift_Del	DEL	C	-	-																															gtgttccctttctagagtgtCctgccatacttcgtagctac																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:43876270delC	uc001mxq.3	+	10	925	c.690delC	c.(688-690)GTCfs	p.V230fs		NM_016142	NP_057226	Q53GQ0	DHB12_HUMAN	hydroxysteroid (17-beta) dehydrogenase 12	230					long-chain fatty-acyl-CoA biosynthetic process|steroid biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	estradiol 17-beta-dehydrogenase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity				0						TCTAGAGTGTCCTGCCATACT	0.463													---	---	---								-	43876270	-	-	43876270	7	5	248	1	0	1	0	1	0	0	0	0	7420	842	30	0	728	0	HSD17B12	11	43876270	Frame_Shift_Del	DEL	C	TCGA-CV-7409-01A-31D-2229-08	3739220	43876270	91130246	170	45605											
OR5D16	390144	broad.mit.edu	37	chr11	55606284	55606284	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acattcactctcttgggcttCtcagattacctggaactgca	9	13	7	12	0	3	1	2	0	2	1	5	2	3	2	1	2	3	2	1	2	2	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:55606284C>T	uc010rio.1	+	1	57	c.57C>T	c.(55-57)TTC>TTT	p.F19F		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TCTTGGGCTTCTCAGATTACC	0.413													38	85					0	0	0	0	T	55606284	T	T	55606284	2	4	248	1	0	0	0	0	0	0	0	1	11210	912	32	2		2	OR5D16	11	55606284	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	11730014	55606284	79400232	171	45606											
OR5W2	390148	broad.mit.edu	37	chr11	55682057	55682057	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagcaattttcccagtccAttcttccttgttcttgtttc	6	18	6	11	0	2	0	0	0	2	0	6	1	5	1	3	1	1	3	3	1	1	8			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:55682057A>T	uc010rir.1	-	1	2	c.2T>A	c.(1-3)ATG>AAG	p.M1K		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTCCCAGTCCATTCTTCCTTG	0.343													7	27					0	0	0	0	T	55682057	T	T	55682057	3	4	248	1	0	0	0	0	1	0	0	0	11239	231	8	5	932	5	OR5W2	11	55682057	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	75773	55682057	79324459	172	45607											
OR5AS1	219447	broad.mit.edu	37	chr11	55798050	55798050	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataattctagttaatattaaTtcaagccttcaaattcccat	15	16	2	8	0	3	0	2	0	1	0	4	0	4	0	2	0	1	1	2	0	7	9			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:55798050T>C	uc010riw.1	+	1	156	c.156T>C	c.(154-156)AAT>AAC	p.N52N		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					TTAATATTAATTCAAGCCTTC	0.328													13	20					0	0	0	0	C	55798050	C	C	55798050	2	2	248	1	0	0	0	0	0	0	0	1	11200	1490	52	5		5	OR5AS1	11	55798050	Silent	SNP	T	TCGA-CV-7409-01A-31D-2229-08	115993	55798050	79208466	173	45608											
OR8H2	390151	broad.mit.edu	37	chr11	55872764	55872765	+	Frame_Shift_Ins	INS	-	T	T																															ctgtcgtcacacctaaaaccINSttagcgaacttactgacttc																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:55872764_55872765insT	uc010riy.1	+	1	246_247	c.246_247insT	c.(244-249)ACCTTAfs	p.T82fs		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	82_83	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CACCTAAAACCTTAGCGAACTT	0.436										HNSCC(53;0.14)			---	---	---								T	55872765	T	T	55872764	7	5	248	1	0	1	1	0	0	0	0	0	11292	668	24	0	248	0	OR8H2	11	55872764	Frame_Shift_Ins	INS	-	TCGA-CV-7409-01A-31D-2229-08	74714	55872764	79133752	174	45609											
OR5R1	219479	broad.mit.edu	37	chr11	56185101	56185101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagagatcatatcaaagccaGcaaaggcaaatatcagaatt	20	7	7	7	0	3	2	3	0	0	2	3	3	3	2	1	1	2	2	1	1	7	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:56185101G>A	uc010rji.1	-	1	608	c.608C>T	c.(607-609)GCT>GTT	p.A203V		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATCAAAGCCAGCAAAGGCAAA	0.438													20	52					0	0	0	0	A	56185101	A	A	56185101	3	1	248	1	0	0	0	0	1	0	0	0	11234	971	34	4	368	4	OR5R1	11	56185101	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	312337	56185101	78821415	175	45610											
OR9G4	283189	broad.mit.edu	37	chr11	56511121	56511121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agataaccaaggtcatgtttCctgacaaggttatcaaatag	15	11	8	7	0	2	2	2	1	0	1	3	2	3	2	2	2	1	2	2	2	6	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:56511121C>T	uc010rjo.1	-	1	167	c.167G>A	c.(166-168)GGA>GAA	p.G56E		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	56	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GGTCATGTTTCCTGACAAGGT	0.403													26	41					0	0	0	0	T	56511121	T	T	56511121	3	4	248	1	0	0	0	0	1	0	0	0	11305	855	30	2	819	2	OR9G4	11	56511121	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	326020	56511121	78495395	176	45611											
OR10W1	81341	broad.mit.edu	37	chr11	58034437	58034437	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgttctgggaaaggcagttCctggtaagaactctccctac	9	11	10	11	0	2	1	0	0	2	1	4	2	3	2	2	3	2	4	2	3	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:58034437C>A	uc001nmq.1	-	1	1296	c.894G>T	c.(892-894)AGG>AGT	p.R298S		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				AAAGGCAGTTCCTGGTAAGAA	0.493													54	75					6.26901e-30	8.50794e-30	1	0	A	58034437	A	A	58034437	3	1	248	1	0	0	0	0	1	0	0	0	10975	854	30	2	27	2	OR10W1	11	58034437	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	1523316	58034437	76972079	177	45612											
PATL1	219988	broad.mit.edu	37	chr11	59420459	59420459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactgctccggtgacttcctCtatctcccgcaccattgaga	7	11	8	15	2	2	2	0	2	2	1	5	4	4	2	4	1	1	2	4	1	1	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:59420459C>T	uc001noe.3	-	10	1297	c.1154G>A	c.(1153-1155)AGA>AAA	p.R385K	PATL1_uc009yms.1_Missense_Mutation_p.R355K|PATL1_uc010rkw.1_Missense_Mutation_p.R90K	NM_152716	NP_689929	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog	385	Region N; interaction with decapping machinery.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			ovary(1)	1						GTGACTTCCTCTATCTCCCGC	0.433													40	195					0	0	0	0	T	59420459	T	T	59420459	3	4	248	1	0	0	0	0	1	0	0	0	11529	913	32	2	1198	2	PATL1	11	59420459	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	1386022	59420459	75586057	178	45613											
MS4A2	2206	broad.mit.edu	37	chr11	59857864	59857865	+	Frame_Shift_Ins	INS	-	T	T																															tttggaacagttgtctgctcINStgtacttgatatttcacaca																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:59857864_59857865insT	uc001nop.2	+	3	344_345	c.242_243insT	c.(241-243)TCTfs	p.S81fs	MS4A2_uc009ymu.2_Frame_Shift_Ins_p.S81fs	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	81	Extracellular (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	GTTGTCTGCTCTGTACTTGATA	0.322													---	---	---								T	59857865	T	T	59857864	7	5	248	1	0	1	1	0	0	0	0	0	9913	913	32	0	252	0	MS4A2	11	59857864	Frame_Shift_Ins	INS	-	TCGA-CV-7409-01A-31D-2229-08	437405	59857864	75148652	179	45614											
PRCP	5547	broad.mit.edu	37	chr11	82571077	82571077	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagtgtagaaaagtattgatCcaccatttttcttccagtat	12	15	6	8	0	1	2	0	1	1	1	3	2	3	2	3	0	0	3	3	0	5	7			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:82571077C>A	uc001ozs.2	-	2	364	c.251G>T	c.(250-252)GGA>GTA	p.G84V	PRCP_uc001ozr.2_Missense_Mutation_p.G105V	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	84					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						AAGTATTGATCCACCATTTTT	0.338													11	22					1.08611e-07	1.19731e-07	1	0	A	82571077	A	A	82571077	3	1	248	1	0	0	0	0	1	0	0	0	12511	855	30	2	1271	2	PRCP	11	82571077	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	22713213	82571077	52435439	180	45615											
ZBTB16	7704	broad.mit.edu	37	chr11	113934426	113934426	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agacgacaatgacacggaggCcaccatggccgatggcgggg	11	3	16	11	4	0	2	0	1	0	1	0	5	0	3	3	6	0	0	3	6	1	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:113934426C>A	uc001pop.2	+	2	668	c.404C>A	c.(403-405)GCC>GAC	p.A135D	ZBTB16_uc001poo.1_Missense_Mutation_p.A135D|ZBTB16_uc001poq.2_Missense_Mutation_p.A135D	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	135					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		GACACGGAGGCCACCATGGCC	0.582													8	29					2.17888e-05	2.28499e-05	1	0	A	113934426	A	A	113934426	3	1	248	1	0	0	0	0	1	0	0	0	17593	739	26	4	406	4	ZBTB16	11	113934426	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	31363349	113934426	21072090	181	45616											
FAM55D	54827	broad.mit.edu	37	chr11	114450889	114450889	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaagtattccatccactggCggatcgtggaatctcccatt	9	12	9	11	2	1	1	0	1	1	0	5	3	3	3	3	3	0	1	3	3	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:114450889C>T	uc001ppc.2	-	5	1245	c.1064G>A	c.(1063-1065)CGC>CAC	p.R355H	FAM55D_uc001ppd.2_Missense_Mutation_p.R71H	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	355						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		CATCCACTGGCGGATCGTGGA	0.418													34	143					0	0	0	0	T	114450889	T	T	114450889	3	4	248	1	0	0	0	0	1	0	0	0	5619	768	27	1	578	1	FAM55D	11	114450889	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	516463	114450889	20555627	182	45617											
ABCG4	64137	broad.mit.edu	37	chr11	119031672	119031672	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttagaggaacgctgcccgttCcgggagccacagagcatcct	9	7	12	13	3	0	2	0	0	0	2	2	4	2	4	4	2	4	3	4	2	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:119031672C>A	uc001pvs.2	+	15	2133	c.1797C>A	c.(1795-1797)TTC>TTA	p.F599L	ABCG4_uc009zar.2_Missense_Mutation_p.F599L	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	599	Extracellular (Potential).|ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCTGCCCGTTCCGGGAGCCAC	0.577													18	24					0.000566183	0.0005769	1	0	A	119031672	A	A	119031672	3	1	248	1	0	0	0	0	1	0	0	0	70	854	30	2	1851	2	ABCG4	11	119031672	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	4580783	119031672	15974844	183	45618											
TECTA	7007	broad.mit.edu	37	chr11	121008261	121008261	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgtgatgagggctatgctCtactgggcagccagtgtgtc	7	11	15	8	0	1	2	0	2	1	0	2	2	1	2	1	2	3	3	1	2	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:121008261C>T	uc010rzo.1	+	10	3073	c.3073C>T	c.(3073-3075)CTA>TTA	p.L1025L		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1025	TIL 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGGCTATGCTCTACTGGGCAG	0.577													25	58					0	0	0	0	T	121008261	T	T	121008261	2	4	248	1	0	0	0	0	0	0	0	1	15813	912	32	2		2	TECTA	11	121008261	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	1976589	121008261	13998255	184	45619											
BSX	390259	broad.mit.edu	37	chr11	122850143	122850143	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccgcgtgctgcgggtgcggGaacagcgctgggactggcat	5	7	18	11	5	0	0	0	0	0	0	1	2	1	2	1	4	5	3	1	4	1	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:122850143G>T	uc010rzs.1	-	2	285	c.285C>A	c.(283-285)TTC>TTA	p.F95L		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	95											0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		GCGGGTGCGGGAACAGCGCTG	0.577													24	61					4.4004e-07	4.76956e-07	1	0	T	122850143	T	T	122850143	3	4	248	1	0	0	0	0	1	0	0	0	1540	1165	41	2	423	2	BSX	11	122850143	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	1841882	122850143	12156373	185	45620											
OR8B12	219858	broad.mit.edu	37	chr11	124412750	124412750	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaggacactttcccttgctcGaggggcaggatggaaagggg	9	7	17	8	1	0	0	0	0	0	0	2	5	1	3	1	7	1	2	1	7	1	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:124412750G>C	uc010sam.1	-	1	801	c.801C>G	c.(799-801)CTC>CTG	p.L267L		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		TCCCTTGCTCGAGGGGCAGGA	0.438													8	38					0	0	0	0	C	124412750	C	C	124412750	2	2	248	1	0	0	0	0	0	0	0	1	11280	1045	37	3		3	OR8B12	11	124412750	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	1562607	124412750	10593766	186	45621											
PANX3	116337	broad.mit.edu	37	chr11	124481559	124481559	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctggaactgcccctggaccGgatagtcaagttcgtagctg	8	10	12	11	2	2	0	1	0	1	0	3	3	2	3	3	3	3	3	3	3	4	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:124481559G>A	uc001qah.2	+	1	107	c.107G>A	c.(106-108)CGG>CAG	p.R36Q		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	36	Cytoplasmic (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CCCCTGGACCGGATAGTCAAG	0.597													27	51					0	0	0	0	A	124481559	A	A	124481559	3	1	248	1	0	0	0	0	1	0	0	0	11476	1116	39	1	109	1	PANX3	11	124481559	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	68809	124481559	10524957	187	45622											
ROBO3	64221	broad.mit.edu	37	chr11	124743986	124743986	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccagcagctggcaacacatGgcgtactgtggcagatggcg	9	6	14	12	2	0	1	0	0	0	1	0	1	0	1	1	4	4	5	1	4	2	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:124743986G>T	uc001qbc.2	+	12	1997	c.1805G>T	c.(1804-1806)TGG>TTG	p.W602L	ROBO3_uc010saq.1_5'Flank|ROBO3_uc001qbd.2_5'Flank|ROBO3_uc010sar.1_5'Flank|ROBO3_uc001qbe.2_5'Flank	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	602	Fibronectin type-III 1.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GGCAACACATGGCGTACTGTG	0.552													99	246					5.97022e-63	9.05343e-63	1	0	T	124743986	T	T	124743986	3	4	248	1	0	0	0	0	1	0	0	0	13580	1357	47	4	1851	4	ROBO3	11	124743986	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	262427	124743986	10262530	188	45623											
GLB1L2	89944	broad.mit.edu	37	chr11	134217282	134217282	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagggcttcaccgaagcagtGgacctttattttgaccacct	10	11	9	11	1	1	1	1	1	0	0	1	3	1	2	4	2	1	2	4	2	3	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr11:134217282G>T	uc001qhp.2	+	5	701	c.513G>T	c.(511-513)GTG>GTT	p.V171V	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	171					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CCGAAGCAGTGGACCTTTATT	0.512													153	298					1.57672e-70	2.41365e-70	1	0	T	134217282	T	T	134217282	2	4	248	1	0	0	0	0	0	0	0	1	6466	1335	47	4		4	GLB1L2	11	134217282	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	9473296	134217282	789234	189	45624											
TAS2R31	259290	broad.mit.edu	37	chr12	11183120	11183120	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggatgaatgggtggattgaaGgatagctgaatctaatagct	13	11	14	3	0	1	3	0	3	1	0	1	6	1	6	0	4	2	2	0	4	6	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:11183120G>A	uc001qzo.1	-	1	887	c.815C>T	c.(814-816)CCT>CTT	p.P272L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	272	Helical; Name=7; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						GTGGATTGAAGGATAGCTGAA	0.418													86	175					0	0	0	0	A	11183120	A	A	11183120	3	1	248	1	0	0	0	0	1	0	0	0	15640	1000	35	4	118	4	TAS2R31	12	11183120	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08		11183120	122668775	190	45625											
TAS2R42	353164	broad.mit.edu	37	chr12	11339153	11339153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agacaatataagaagcataaCaatcattccgttcatcctcc	16	10	4	11	1	2	2	2	0	0	2	5	2	5	2	3	0	2	2	3	0	6	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:11339153C>T	uc001qzr.1	-	1	391	c.391G>A	c.(391-393)GTT>ATT	p.V131I	PRB4_uc001qzf.1_Intron	NM_181429	NP_852094	Q7RTR8	T2R42_HUMAN	taste receptor, type 2, member 42	131	Helical; Name=3; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0455)			AGAAGCATAACAATCATTCCG	0.368													13	34					0	0	0	0	T	11339153	T	T	11339153	3	4	248	1	0	0	0	0	1	0	0	0	15646	478	17	4	557	4	TAS2R42	12	11339153	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	156033	11339153	122512742	191	45626											
LRRK2	120892	broad.mit.edu	37	chr12	40671795	40671795	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccatcaaatgtcttccaatAtcatggaacaaaaggatcaa	17	10	5	9	0	4	0	3	0	1	0	6	2	6	2	2	2	1	0	2	2	7	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:40671795A>T	uc001rmg.3	+	17	2168	c.2047A>T	c.(2047-2049)ATC>TTC	p.I683F	LRRK2_uc001rmh.1_Missense_Mutation_p.I305F	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	683					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GTCTTCCAATATCATGGAACA	0.333													19	36					0	0	0	0	T	40671795	T	T	40671795	3	4	248	1	0	0	0	0	1	0	0	0	9083	449	16	5	2113	5	LRRK2	12	40671795	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	29332642	40671795	93180100	192	45627											
ADAMTS20	80070	broad.mit.edu	37	chr12	43763140	43763140	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atctccagctgtggcaaatgGaactgcatttccaaatattg	12	12	8	9	0	1	0	0	0	1	0	3	1	2	1	2	2	3	3	2	2	4	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:43763140G>A	uc010skx.1	-	37	5491	c.5491C>T	c.(5491-5493)CCA>TCA	p.P1831S		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1831	GON.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GTGGCAAATGGAACTGCATTT	0.328													3	8					0	0	0	0	A	43763140	A	A	43763140	3	1	248	1	0	0	0	0	1	0	0	0	266	1174	41	2	252	2	ADAMTS20	12	43763140	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	3091345	43763140	90088755	193	45628											
KRT79	338785	broad.mit.edu	37	chr12	53227957	53227957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cactgagctgaagctggtgcGggcctgggacccactccctc	6	7	13	15	1	0	2	0	2	0	0	2	3	1	3	3	3	3	2	3	3	1	0	rs142757937	byFrequency	TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:53227957G>A	uc001sbb.2	-	1	121	c.88C>T	c.(88-90)CGC>TGC	p.R30C		NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	30	Head.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						AAGCTGGTGCGGGCCTGGGAC	0.647													10	48					0	0	0	0	A	53227957	A	A	53227957	3	1	248	1	0	0	0	0	1	0	0	0	8531	1116	39	1	1555	1	KRT79	12	53227957	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	9464817	53227957	80623938	194	45629											
ATF7	11016	broad.mit.edu	37	chr12	53994853	53994853	+	5'Flank	DEL	C	-	-																															ttatgttaaatatgctggagCaaaaaaaaaaaaaaagtgct																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:53994853delC	uc001sdy.2	-						ATF7_uc010sok.1_Intron|ATF7_uc001sdz.2_Intron|ATF7_uc010sol.1_Intron|ATF7_uc001sea.3_Intron|ATF7_uc001seb.3_Intron	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1						interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						TATGCTGGAGCAAAAAAAAAA	0.418													---	---	---								-	53994853	-	-	53994853	6	5	248	0	1	1	0	1	0	0	0	0	1088	725	25	0		0	ATF7	12	53994853	5'Flank	DEL	C	TCGA-CV-7409-01A-31D-2229-08	766896	53994853	79857042	195	45630											
RASSF3	283349	broad.mit.edu	37	chr12	65078646	65078646	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agttcataaatacaacttagCagtcacagacaagttgaaga	18	9	7	7	0	2	3	2	1	0	2	2	3	2	3	0	0	3	3	0	0	7	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:65078646C>T	uc001ssd.2	+	2	311	c.191C>T	c.(190-192)GCA>GTA	p.A64V	RASSF3_uc009zqn.2_RNA|RASSF3_uc001sse.2_5'UTR	NM_178169	NP_835463	Q86WH2	RASF3_HUMAN	Ras association (RalGDS/AF-6) domain family	64					signal transduction	cytoplasm|microtubule	identical protein binding				0			Lung(2;0.00133)|LUAD - Lung adenocarcinoma(6;0.0665)|LUSC - Lung squamous cell carcinoma(43;0.132)	GBM - Glioblastoma multiforme(28;0.0611)		TACAACTTAGCAGTCACAGAC	0.358													12	28					0	0	0	0	T	65078646	T	T	65078646	3	4	248	1	0	0	0	0	1	0	0	0	13152	710	25	4	197	4	RASSF3	12	65078646	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	11083793	65078646	68773249	196	45631											
GLIPR1L2	144321	broad.mit.edu	37	chr12	75804291	75804291	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acgcataatatttatttacaAgatgtacaaatggtccatcc	15	13	5	8	1	0	1	0	0	0	1	2	1	2	1	2	1	2	2	2	1	7	7			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:75804291A>T	uc001sxr.1	+	2	320	c.312A>T	c.(310-312)CAA>CAT	p.Q104H	GLIPR1L2_uc001sxp.1_Missense_Mutation_p.Q104H|GLIPR1L2_uc001sxq.1_Translation_Start_Site	NM_152436	NP_689649	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	104						integral to membrane				ovary(1)	1						TTTATTTACAAGATGTACAAA	0.348													19	57					0	0	0	0	T	75804291	T	T	75804291	3	4	248	1	0	0	0	0	1	0	0	0	6480	69	3	5	318	5	GLIPR1L2	12	75804291	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	10725645	75804291	58047604	197	45632											
NAV3	89795	broad.mit.edu	37	chr12	78444926	78444926	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggactgatgacatcaacagtGggtaagtaaccctgttctcc	11	10	10	10	0	2	2	1	2	1	0	3	3	2	3	2	2	2	3	2	2	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:78444926G>A	uc001syp.2	+	11	2688	c.2515G>A	c.(2515-2517)GGG>AGG	p.G839R	NAV3_uc001syo.2_Missense_Mutation_p.G839R|NAV3_uc010sub.1_Missense_Mutation_p.G339R	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	839						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CATCAACAGTGGGTAAGTAAC	0.448										HNSCC(70;0.22)			29	45					0	0	0	0	A	78444926	A	A	78444926	3	1	248	1	0	0	0	0	1	0	0	0	10238	1362	47	4	2557	4	NAV3	12	78444926	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	2640635	78444926	55406969	198	45633											
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100491235	100491235	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtgaactttgggtggcatCtgcctctattcttatcatct	7	17	8	9	0	5	1	1	1	4	0	5	1	5	1	1	2	2	1	1	2	3	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:100491235C>T	uc001tgq.2	-	6	806	c.577G>A	c.(577-579)GAT>AAT	p.D193N	UHRF1BP1L_uc001tgr.2_Missense_Mutation_p.D193N	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	193										ovary(2)	2						TGGGTGGCATCTGCCTCTATT	0.358													16	17					0	0	0	0	T	100491235	T	T	100491235	3	4	248	1	0	0	0	0	1	0	0	0	17037	913	32	2	3905	2	UHRF1BP1L	12	100491235	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	22046309	100491235	33360660	199	45634											
SSH1	54434	broad.mit.edu	37	chr12	109186136	109186136	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcaggttttgatcgagctGggttggaagctgcccccacc	7	9	14	11	1	0	1	0	1	0	0	1	4	0	2	3	3	4	5	3	3	1	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr12:109186136G>C	uc001tnm.2	-	14	1906	c.1819C>G	c.(1819-1821)CAG>GAG	p.Q607E	SSH1_uc001tnl.2_Missense_Mutation_p.Q295E|SSH1_uc010sxg.1_Missense_Mutation_p.Q618E|SSH1_uc001tnn.3_Missense_Mutation_p.Q607E	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	607					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						TGATCGAGCTGGGTTGGAAGC	0.617													17	75					0	0	0	0	C	109186136	C	C	109186136	3	2	248	1	0	0	0	0	1	0	0	0	15250	1357	47	4	1524	4	SSH1	12	109186136	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	8694901	109186136	24665759	200	45635											
FRY	10129	broad.mit.edu	37	chr13	32757164	32757164	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagaagctctggaaagaaGaccagaggtaagaatttgaa	19	6	12	4	0	1	6	0	1	1	5	1	8	1	7	1	2	1	2	1	2	7	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr13:32757164G>T	uc001utx.2	+	24	3543	c.3047G>T	c.(3046-3048)AGA>ATA	p.R1016I	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1016					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTGGAAAGAAGACCAGAGGTA	0.318													9	6					5.4927e-09	6.24698e-09	1	0	T	32757164	T	T	32757164	3	4	248	1	0	0	0	0	1	0	0	0	6097	942	33	2	3141	2	FRY	13	32757164	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08		32757164	82412714	201	45636											
PCDH17	27253	broad.mit.edu	37	chr13	58207782	58207782	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgagcgaggccgcccctcccGgcaccgtcatcgccctggtg	4	6	13	18	5	1	1	1	1	0	0	3	2	2	1	6	3	1	1	6	3	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr13:58207782G>A	uc001vhq.1	+	1	1994	c.1102G>A	c.(1102-1104)GGC>AGC	p.G368S	PCDH17_uc010aec.1_Missense_Mutation_p.G368S	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	368	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CGCCCCTCCCGGCACCGTCAT	0.627													34	28					0	0	0	0	A	58207782	A	A	58207782	3	1	248	1	0	0	0	0	1	0	0	0	11566	1116	39	1	1104	1	PCDH17	13	58207782	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	25450618	58207782	56962096	202	45637											
MYO16	23026	broad.mit.edu	37	chr13	109793138	109793138	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acccccgtcacctgctccccCgcctccgacgagtcgcccct	4	6	7	24	5	1	0	1	0	0	0	4	2	3	0	9	0	1	1	9	0	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr13:109793138C>T	uc001vqt.1	+	32	4638	c.4512C>T	c.(4510-4512)CCC>CCT	p.P1504P	MYO16_uc010agk.1_Silent_p.P1526P	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1504	Pro-rich.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCTGCTCCCCCGCCTCCGACG	0.726													14	12					0	0	0	0	T	109793138	T	T	109793138	2	4	248	1	0	0	0	0	0	0	0	1	10117	639	23	1		1	MYO16	13	109793138	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	51585356	109793138	5376740	203	45638											
ATP11A	23250	broad.mit.edu	37	chr13	113474237	113474237	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgtgggtcgcatcaacgtttAcagtgacctgaatgaccccg	9	9	11	12	4	1	3	1	3	0	0	2	3	1	3	3	1	2	2	3	1	3	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr13:113474237A>T	uc001vsi.3	+	8	786	c.698A>T	c.(697-699)TAC>TTC	p.Y233F	ATP11A_uc001vsj.3_Missense_Mutation_p.Y233F|ATP11A_uc001vsm.1_Missense_Mutation_p.Y109F	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	233	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				ATCAACGTTTACAGTGACCTG	0.617													27	39					0	0	0	0	T	113474237	T	T	113474237	3	4	248	1	0	0	0	0	1	0	0	0	1121	391	14	5	728	5	ATP11A	13	113474237	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	3681099	113474237	1695641	204	45639											
SLC8A3	6547	broad.mit.edu	37	chr14	70518747	70518747	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caatgatgacttctagtttgGggtgttcacccaatactggc	9	13	10	9	0	2	2	1	2	1	0	2	2	2	2	1	3	1	2	1	3	4	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr14:70518747G>T	uc001xly.2	-	5	2745	c.1991C>A	c.(1990-1992)CCC>CAC	p.P664H	SLC8A3_uc001xlu.2_Missense_Mutation_p.P21H|SLC8A3_uc001xlv.2_Missense_Mutation_p.P35H|SLC8A3_uc001xlw.2_Missense_Mutation_p.P661H|SLC8A3_uc001xlx.2_Missense_Mutation_p.P662H|SLC8A3_uc001xlz.2_Missense_Mutation_p.P658H|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_Missense_Mutation_p.P21H	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	664	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TTCTAGTTTGGGGTGTTCACC	0.383													39	40					8.20599e-20	1.04352e-19	1	0	T	70518747	T	T	70518747	3	4	248	1	0	0	0	0	1	0	0	0	14772	1232	43	4	808	4	SLC8A3	14	70518747	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08		70518747	36830793	205	45640											
ESRRB	2103	broad.mit.edu	37	chr14	76949004	76949004	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctatgccatgcctccccCtggtatgcctgagggggaca	6	9	12	14	0	1	1	0	1	1	0	2	2	2	2	5	3	3	2	5	3	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr14:76949004C>T	uc001xsq.1	+	5	756	c.689C>T	c.(688-690)CCT>CTT	p.P230L	ESRRB_uc001xsr.2_Missense_Mutation_p.P230L|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	230						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		ATGCCTCCCCCTGGTATGCCT	0.557													60	52					0	0	0	0	T	76949004	T	T	76949004	3	4	248	1	0	0	0	0	1	0	0	0	5285	681	24	4	703	4	ESRRB	14	76949004	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	6430257	76949004	30400536	206	45641											
KCNK10	54207	broad.mit.edu	37	chr14	88729659	88729659	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctcaaagggctgctccaatgCccggaagacaagaccgccag	12	4	11	14	2	1	2	1	0	0	2	2	3	2	3	4	2	2	2	4	2	4	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr14:88729659C>G	uc001xwo.2	-	2	731	c.274G>C	c.(274-276)GCA>CCA	p.A92P	KCNK10_uc001xwm.2_Missense_Mutation_p.A97P|KCNK10_uc001xwn.2_Missense_Mutation_p.A97P	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	92	Helical; (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						TGCTCCAATGCCCGGAAGACA	0.572													17	86					0	0	0	0	G	88729659	G	G	88729659	3	3	248	1	0	0	0	0	1	0	0	0	8098	739	26	4	1366	4	KCNK10	14	88729659	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	11780655	88729659	18619881	207	45642											
KIAA1409	57578	broad.mit.edu	37	chr14	94109931	94109931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgtggggccattcttgaaGaatacgatgaagagacactt	13	10	11	7	1	1	4	0	2	1	2	1	6	1	4	1	2	1	0	1	2	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr14:94109931G>A	uc001ybv.1	+	33	5667	c.5584G>A	c.(5584-5586)GAA>AAA	p.E1862K	KIAA1409_uc001ybs.1_Missense_Mutation_p.E1840K	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2017						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CATTCTTGAAGAATACGATGA	0.468													72	39					0	0	0	0	A	94109931	A	A	94109931	3	1	248	1	0	0	0	0	1	0	0	0	8269	943	33	2	5644	2	KIAA1409	14	94109931	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	5380272	94109931	13239609	208	45643											
KIAA0284	283638	broad.mit.edu	37	chr14	105361114	105361114	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggaaacaggagcttggccaGctctgcacagccggggctgg	9	5	16	11	1	1	0	0	0	1	0	1	2	1	2	2	6	5	4	2	6	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr14:105361114G>C	uc010axb.2	+	19	4708	c.4484G>C	c.(4483-4485)AGC>ACC	p.S1495T	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.S1425T|KIAA0284_uc001yps.2_Missense_Mutation_p.S1436T|KIAA0284_uc001ypt.2_Missense_Mutation_p.S163T	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	1530						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		AGCTTGGCCAGCTCTGCACAG	0.682													24	121					0	0	0	0	C	105361114	C	C	105361114	3	2	248	1	0	0	0	0	1	0	0	0	8205	971	34	4	4554	4	KIAA0284	14	105361114	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	11251183	105361114	1988426	209	45644											
GABRB3	2562	broad.mit.edu	37	chr15	26866546	26866546	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcacaaatgactttttgtCatttaagaaatatgtgtcgg	13	15	8	5	1	1	2	1	1	0	1	2	2	1	2	0	1	1	1	0	1	4	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr15:26866546C>A	uc001zaz.2	-	4	518	c.376G>T	c.(376-378)GAC>TAC	p.D126Y	GABRB3_uc010uae.1_Missense_Mutation_p.D41Y|GABRB3_uc001zba.2_Missense_Mutation_p.D126Y|GABRB3_uc001zbb.2_Missense_Mutation_p.D182Y|GABRB3_uc001zbc.2_RNA	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	126	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GACTTTTTGTCATTTAAGAAA	0.493													34	62					8.73648e-17	1.07296e-16	1	0	A	26866546	A	A	26866546	3	1	248	1	0	0	0	0	1	0	0	0	6202	826	29	2	1069	2	GABRB3	15	26866546	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08		26866546	75664846	210	45645											
OCA2	4948	broad.mit.edu	37	chr15	28235776	28235776	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggaacccagcatggccgcCagagttctgtgcacgatctg	9	7	13	12	2	2	1	0	0	2	1	2	3	2	2	3	2	3	3	3	2	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr15:28235776C>A	uc001zbh.3	-	10	1172	c.1062G>T	c.(1060-1062)CTG>CTT	p.L354L	OCA2_uc010ayv.2_Intron	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	354	Helical; (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GCATGGCCGCCAGAGTTCTGT	0.557									Oculocutaneous_Albinism				120	176					1.20306e-52	1.79073e-52	1	0	A	28235776	A	A	28235776	2	1	248	1	0	0	0	0	0	0	0	1	10869	581	21	4		4	OCA2	15	28235776	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	1369230	28235776	74295616	211	45646											
PLCB2	5330	broad.mit.edu	37	chr15	40584265	40584265	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtgcaggcaacacagacCtcaggcagacctcccatggc	11	4	11	15	0	1	2	1	0	0	2	2	2	2	2	3	3	2	4	3	3	1	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr15:40584265C>T	uc001zld.2	-	23	2827	c.2526G>A	c.(2524-2526)GAG>GAA	p.E842E	PLCB2_uc001zlc.2_5'Flank|PLCB2_uc010bbo.2_Silent_p.E838E|PLCB2_uc010ucm.1_Silent_p.E842E	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	842					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		CAACACAGACCTCAGGCAGAC	0.597													29	55					0	0	0	0	T	40584265	T	T	40584265	2	4	248	1	0	0	0	0	0	0	0	1	12083	695	24	4		4	PLCB2	15	40584265	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	12348489	40584265	61947127	212	45647											
SECISBP2L	9728	broad.mit.edu	37	chr15	49327610	49327610	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtccaagctgacttggaCgctcagtgcattctgtggtg	6	12	12	11	1	2	1	1	1	1	0	3	2	3	2	2	2	2	3	2	2	1	2	rs138614543		TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr15:49327610C>T	uc001zxe.1	-	3	583	c.449G>A	c.(448-450)CGT>CAT	p.R150H	SECISBP2L_uc001zxd.1_Missense_Mutation_p.R150H|SECISBP2L_uc010bep.1_5'UTR|SECISBP2L_uc010beq.1_Missense_Mutation_p.R150H	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	150										breast(1)|skin(1)	2						CTGACTTGGACGCTCAGTGCA	0.468													30	87					0	0	0	0	T	49327610	T	T	49327610	3	4	248	1	0	0	0	0	1	0	0	0	14072	536	19	1	2781	1	SECISBP2L	15	49327610	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	8743345	49327610	53203782	213	45648											
NARG2	79664	broad.mit.edu	37	chr15	60760373	60760373	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgctctctctgtgagaaacGagagaaacgaggataaggaa	15	7	12	7	2	2	2	0	1	2	2	3	8	2	4	0	2	3	1	0	2	4	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr15:60760373G>A	uc002agp.2	-	4	530	c.295C>T	c.(295-297)CGT>TGT	p.R99C	NARG2_uc002ago.2_Intron|NARG2_uc010bgk.2_Missense_Mutation_p.R99C|NARG2_uc002agr.1_Missense_Mutation_p.R99C	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	99						nucleus				ovary(1)|lung(1)	2						TGTGAGAAACGAGAGAAACGA	0.393													19	29					0	0	0	0	A	60760373	A	A	60760373	3	1	248	1	0	0	0	0	1	0	0	0	10222	1058	37	1	2705	1	NARG2	15	60760373	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	11432763	60760373	41771019	214	45649											
TLN2	83660	broad.mit.edu	37	chr15	63014680	63014680	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggagctgcgtaccgcctcGcagaaggcaagtggagcgtg	8	5	17	11	5	0	1	0	0	0	1	1	3	0	3	2	3	4	4	2	3	3	1	rs148420994	byFrequency	TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr15:63014680G>A	uc002alb.3	+	23	3120	c.3120G>A	c.(3118-3120)TCG>TCA	p.S1040S		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1040	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						GTACCGCCTCGCAGAAGGCAA	0.617													12	39					0	0	0	0	A	63014680	A	A	63014680	2	1	248	1	0	0	0	0	0	0	0	1	16014	1074	38	1		1	TLN2	15	63014680	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	2254307	63014680	39516712	215	45650											
CLPX	10845	broad.mit.edu	37	chr15	65447147	65447147	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgctgaataaggcctggtaCtgaggaataacagcatttcg	13	10	11	7	1	0	2	0	2	0	0	1	3	0	3	1	3	4	3	1	3	5	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr15:65447147C>T	uc002aom.2	-	11	1656	c.1584G>A	c.(1582-1584)CAG>CAA	p.Q528Q	CLPX_uc010uiu.1_RNA	NM_006660	NP_006651	O76031	CLPX_HUMAN	ClpX caseinolytic protease X homolog precursor	528					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding				0						AGGCCTGGTACTGAGGAATAA	0.343													20	19					0	0	0	0	T	65447147	T	T	65447147	2	4	248	1	0	0	0	0	0	0	0	1	3571	564	20	4		4	CLPX	15	65447147	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	2432467	65447147	37084245	216	45651											
CHRNA5	1138	broad.mit.edu	37	chr15	78880684	78880684	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agatgtaaaattaagatggaAccctgatgactatggtggaa	16	10	11	4	0	0	4	0	2	0	2	0	6	0	6	1	3	1	1	1	3	6	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr15:78880684A>T	uc002bdy.2	+	4	494	c.332A>T	c.(331-333)AAC>ATC	p.N111I	CHRNA5_uc002bdz.2_Missense_Mutation_p.N111I	NM_000745	NP_000736	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5	111	Extracellular (Potential).				behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TTAAGATGGAACCCTGATGAC	0.308													13	30					0	0	0	0	T	78880684	T	T	78880684	3	4	248	1	0	0	0	0	1	0	0	0	3401	43	2	5	346	5	CHRNA5	15	78880684	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	13433537	78880684	23650708	217	45652											
SCNN1B	6338	broad.mit.edu	37	chr16	23364139	23364139	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtattccaaaatcaagcAtttgctgaaggacctggatg	13	10	10	8	0	1	1	1	1	0	0	2	3	2	3	2	3	2	3	2	3	5	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr16:23364139A>G	uc002dln.2	+	3	505	c.329A>G	c.(328-330)CAT>CGT	p.H110R		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	110	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	AAAATCAAGCATTTGCTGAAG	0.502													44	80					0	0	0	0	G	23364139	G	G	23364139	3	3	248	1	0	0	0	0	1	0	0	0	13993	217	8	5	335	5	SCNN1B	16	23364139	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08		23364139	66990614	218	45653											
SETD1A	9739	broad.mit.edu	37	chr16	30976967	30976967	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acatggagatctccgacgacGaccggggtggctcaccccct	8	6	12	15	4	2	1	1	0	1	1	3	5	2	1	4	4	0	1	4	4	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr16:30976967G>C	uc002ead.1	+	8	2451	c.1765G>C	c.(1765-1767)GAC>CAC	p.D589H		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	589	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CTCCGACGACGACCGGGGTGG	0.557													23	62					0	0	0	0	C	30976967	C	C	30976967	3	2	248	1	0	0	0	0	1	0	0	0	14195	1058	37	3	1791	3	SETD1A	16	30976967	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	7612828	30976967	59377786	219	45654											
STX4	6810	broad.mit.edu	37	chr16	31051061	31051061	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagaaagtcttgattgcCatctgtgtgtccatcaccgt	10	12	9	10	1	3	3	1	1	2	2	4	3	4	3	3	0	1	0	3	0	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr16:31051061C>T	uc002eal.2	+	10	1055	c.831C>T	c.(829-831)GCC>GCT	p.A277A	STX4_uc002eak.2_Silent_p.A275A|STX4_uc002eam.2_Silent_p.A199A|uc002ean.1_5'Flank	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	277	Helical; Anchor for type IV membrane protein; (Potential).|Interaction with CENPF (By similarity).				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						TCTTGATTGCCATCTGTGTGT	0.582													65	191					0	0	0	0	T	31051061	T	T	31051061	2	4	248	1	0	0	0	0	0	0	0	1	15413	581	21	4		4	STX4	16	31051061	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	74094	31051061	59303692	220	45655											
IRX3	79191	broad.mit.edu	37	chr16	54319493	54319493	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccgcggccggatgctgcacCccggggctgtccttcagctc	3	7	14	17	4	1	0	1	0	0	0	3	1	2	1	5	4	3	4	5	4	0	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr16:54319493C>T	uc002eht.1	-	2	716	c.300G>A	c.(298-300)GGG>GGA	p.G100G		NM_024336	NP_077312	P78415	IRX3_HUMAN	iroquois homeobox 3	100					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GATGCTGCACCCCGGGGCTGT	0.692													2	4					0	0	0	0	T	54319493	T	T	54319493	2	4	248	1	0	0	0	0	0	0	0	1	7884	610	22	4		4	IRX3	16	54319493	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	23268432	54319493	36035260	221	45656											
CES1	1066	broad.mit.edu	37	chr16	55850844	55850844	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaaggtccttacctctctggGgtctccctgtaagtccagag	8	11	10	12	0	2	1	0	0	2	1	6	1	4	1	4	3	1	1	4	3	3	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr16:55850844G>T	uc002eim.2	-	8	1042	c.934C>A	c.(934-936)CCC>ACC	p.P312T	CES1_uc010ccf.2_5'UTR|CES1_uc002eil.2_Missense_Mutation_p.P313T|CES1_uc002ein.2_Missense_Mutation_p.P312T	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	312					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	ACCTCTCTGGGGTCTCCCTGT	0.468													78	172					2.98122e-55	4.47877e-55	1	0	T	55850844	T	T	55850844	3	4	248	1	0	0	0	0	1	0	0	0	3284	1232	43	4	797	4	CES1	16	55850844	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	1531351	55850844	34503909	222	45657											
HYDIN	54768	broad.mit.edu	37	chr16	71026054	71026054	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcagcctctgaggttgctGggatggactccatctgggac	6	10	15	10	0	2	1	0	1	2	0	3	4	3	4	2	5	2	3	2	5	0	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr16:71026054G>T	uc002ezr.2	-	24	3832	c.3704C>A	c.(3703-3705)CCA>CAA	p.P1235Q		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1235										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TGAGGTTGCTGGGATGGACTC	0.512													37	82					1.58521e-26	2.09845e-26	1	0	T	71026054	T	T	71026054	3	4	248	1	0	0	0	0	1	0	0	0	7506	1348	47	4	11910	4	HYDIN	16	71026054	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	15175210	71026054	19328699	223	45658											
FTSJD1	55783	broad.mit.edu	37	chr16	71318551	71318551	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtatttgtactacaaccaaTactagatttttttactagcc	12	17	4	8	0	0	1	0	0	0	1	0	1	0	1	2	0	6	2	2	0	9	11			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr16:71318551T>C	uc010cga.2	-	3	1679	c.1273A>G	c.(1273-1275)ATT>GTT	p.I425V	FTSJD1_uc002ezy.3_Missense_Mutation_p.I425V|FTSJD1_uc002ezz.3_Missense_Mutation_p.I425V	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	425						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						CTACAACCAATACTAGATTTT	0.289													6	23					0	0	0	0	C	71318551	C	C	71318551	3	2	248	1	0	0	0	0	1	0	0	0	6124	1406	49	5	1043	5	FTSJD1	16	71318551	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	292497	71318551	19036202	224	45659											
ZNRF1	84937	broad.mit.edu	37	chr16	75033821	75033821	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcaccggcgactccgagagGgcgcccggcggcggagggtc	5	2	20	14	7	0	1	0	0	0	1	2	4	1	2	3	7	0	1	3	7	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr16:75033821G>A	uc002fdk.2	+	1	907	c.252G>A	c.(250-252)AGG>AGA	p.R84R	ZNRF1_uc010vmz.1_Silent_p.R84R|ZNRF1_uc002fdl.1_Silent_p.R84R|ZNRF1_uc010cgr.1_Silent_p.R84R	NM_032268	NP_115644	Q8ND25	ZNRF1_HUMAN	zinc and ring finger protein 1	84						cell junction|endosome|lysosome|synaptic vesicle membrane	ligase activity|protein binding|zinc ion binding				0						ACTCCGAGAGGGCGCCCGGCG	0.706													4	8					0	0	0	0	A	75033821	A	A	75033821	2	1	248	1	0	0	0	0	0	0	0	1	18278	1223	43	4		4	ZNRF1	16	75033821	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	3715270	75033821	15320932	225	45660											
ADAMTS18	170692	broad.mit.edu	37	chr16	77328833	77328833	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgttacctgagaccagggtCcaaggctccattgtggaggg	8	9	14	10	0	0	1	0	1	0	1	2	3	2	2	4	4	1	2	4	4	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr16:77328833C>T	uc002ffc.3	-	19	3412	c.2993G>A	c.(2992-2994)GGA>GAA	p.G998E	ADAMTS18_uc010chc.1_Missense_Mutation_p.G586E	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	998	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						AGACCAGGGTCCAAGGCTCCA	0.537													16	41					0	0	0	0	T	77328833	T	T	77328833	3	4	248	1	0	0	0	0	1	0	0	0	263	855	30	2	692	2	ADAMTS18	16	77328833	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	2295012	77328833	13025920	226	45661											
PRPF8	10594	broad.mit.edu	37	chr17	1576445	1576445	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggaagcgctgcattgacTcatcgtccacacgcaggaaa	11	8	11	11	3	1	1	1	1	0	0	3	3	2	3	1	2	2	3	1	2	2	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr17:1576445T>C	uc002fte.2	-	24	3818	c.3704A>G	c.(3703-3705)GAG>GGG	p.E1235G		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1235						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CTGCATTGACTCATCGTCCAC	0.547													53	30					0	0	0	0	C	1576445	C	C	1576445	3	2	248	1	0	0	0	0	1	0	0	0	12637	1551	54	5	3383	5	PRPF8	17	1576445	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08		1576445	79618765	227	45662											
SERPINF2	5345	broad.mit.edu	37	chr17	1650637	1650637	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagatttcctggaacaatcCgaacagctatttggggcaaa	14	9	10	8	1	0	1	0	0	0	1	2	4	2	2	2	3	3	2	2	3	6	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr17:1650637C>A	uc002ftk.1	+	7	623	c.546C>A	c.(544-546)TCC>TCA	p.S182S	SERPINF2_uc010vqr.1_Silent_p.S118S	NM_000934	NP_000925	P08697	A2AP_HUMAN	alpha-2-antiplasmin isoform a precursor	182					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	TGGAACAATCCGAACAGCTAT	0.567													8	31					7.48243e-07	8.05608e-07	1	0	A	1650637	A	A	1650637	2	1	248	1	0	0	0	0	0	0	0	1	14180	639	23	3		3	SERPINF2	17	1650637	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	74192	1650637	79544573	228	45663											
TP53	7157	broad.mit.edu	37	chr17	7578526	7578526	+	Frame_Shift_Del	DEL	C	-	-																															ggcaggtcttggccagttggCaaaacatcttgttgagggca																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr17:7578526delC	uc002gim.2	-	5	598	c.404delG	c.(403-405)TGCfs	p.C135fs	TP53_uc002gig.1_Frame_Shift_Del_p.C135fs|TP53_uc002gih.2_Frame_Shift_Del_p.C135fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.C3fs|TP53_uc010cng.1_Frame_Shift_Del_p.C3fs|TP53_uc002gii.1_Frame_Shift_Del_p.C3fs|TP53_uc010cnh.1_Frame_Shift_Del_p.C135fs|TP53_uc010cni.1_Frame_Shift_Del_p.C135fs|TP53_uc002gij.2_Frame_Shift_Del_p.C135fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.C42fs|TP53_uc002gio.2_Frame_Shift_Del_p.C3fs|TP53_uc010vug.1_Frame_Shift_Del_p.C96fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	135	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation; decreased E6-mediated binding to E6-AP).|C -> T (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C135Y(51)|p.C135F(34)|p.C135W(19)|p.C135S(10)|p.C135fs*35(9)|p.0?(7)|p.C135*(7)|p.C135G(6)|p.C135R(6)|p.C135C(5)|p.C135fs*14(2)|p.N131fs*27(2)|p.F134_T140>S(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.C135T(1)|p.V73fs*9(1)|p.C135fs*36(1)|p.C135fs*15(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.C42Y(1)|p.C3Y(1)|p.M133fs*13(1)|p.C135_T140delCQLAKT(1)|p.Q136fs*13(1)|p.C135_Q136insXXXXXX(1)|p.C135_Q136insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCAGTTGGCAAAACATCTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578526	-	-	7578526	7	5	248	1	0	1	0	1	0	0	0	0	16448	710	25	0	894	0	TP53	17	7578526	Frame_Shift_Del	DEL	C	TCGA-CV-7409-01A-31D-2229-08	5927889	7578526	73616684	229	45664											
FLII	2314	broad.mit.edu	37	chr17	18151089	18151089	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaccaggcgcggggacttgCggccgagccagatgaacacg	9	3	16	13	5	0	2	0	1	0	1	0	4	0	3	3	4	3	1	3	4	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr17:18151089C>A	uc002gsr.1	-	20	2420	c.2369G>T	c.(2368-2370)CGC>CTC	p.R790L	FLII_uc002gsq.1_Missense_Mutation_p.R661L|FLII_uc010cpy.1_Missense_Mutation_p.R779L|FLII_uc010vxn.1_Missense_Mutation_p.R759L|FLII_uc010vxo.1_Missense_Mutation_p.R735L|FLII_uc002gss.1_Missense_Mutation_p.R789L	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	790	Interaction with ACTL6A.|Gelsolin-like 3.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					CGGGGACTTGCGGCCGAGCCA	0.672													32	15					4.0492e-12	4.79081e-12	1	0	A	18151089	A	A	18151089	3	1	248	1	0	0	0	0	1	0	0	0	5957	768	27	3	1484	3	FLII	17	18151089	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	10572563	18151089	63044121	230	45665											
RDM1	201299	broad.mit.edu	37	chr17	34251686	34251686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaggatggcaacaccacttCtaaagcacagaagaacttca	17	6	7	11	0	2	2	1	0	1	2	2	3	2	3	1	2	3	2	1	2	5	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr17:34251686C>T	uc002hkh.2	-	4	539	c.490G>A	c.(490-492)GAA>AAA	p.E164K	RDM1_uc010cty.2_Intron|RDM1_uc010ctz.2_Intron|RDM1_uc010cua.2_Missense_Mutation_p.E141K|RDM1_uc002hkg.3_Missense_Mutation_p.E141K|RDM1_uc010cub.2_Intron|RDM1_uc010cud.2_Missense_Mutation_p.E164K|RDM1_uc010cuf.2_Intron|RDM1_uc010cue.2_Intron|RDM1_uc010cug.2_Intron|RDM1_uc010cuc.2_Intron|RDM1_uc010wco.1_Intron|RDM1_uc010wcp.1_Missense_Mutation_p.E141K|RDM1_uc002hki.2_Missense_Mutation_p.E164K	NM_145654	NP_663629	Q8NG50	RDM1_HUMAN	RAD52 motif 1 isoform 1	164					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AACACCACTTCTAAAGCACAG	0.488								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					24	84					0	0	0	0	T	34251686	T	T	34251686	3	4	248	1	0	0	0	0	1	0	0	0	13262	922	32	2	424	2	RDM1	17	34251686	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	16100597	34251686	46943524	231	45666											
BECN1	8678	broad.mit.edu	37	chr17	40967928	40967928	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccctagctctcattaccaGatgtggaaggttgcattaaa	11	12	8	10	0	1	1	1	0	1	1	3	2	2	2	3	2	3	3	3	2	5	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr17:40967928G>A	uc002ibo.3	-	8	963	c.828C>T	c.(826-828)ATC>ATT	p.I276I	BECN1_uc010whb.1_Silent_p.I189I|BECN1_uc010whc.1_Silent_p.I200I|BECN1_uc002ibn.2_Silent_p.I276I	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	276					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		CTCATTACCAGATGTGGAAGG	0.483													69	71					0	0	0	0	A	40967928	A	A	40967928	2	1	248	1	0	0	0	0	0	0	0	1	1398	932	33	2		2	BECN1	17	40967928	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	6716242	40967928	40227282	232	45667											
RAD51C	5889	broad.mit.edu	37	chr17	56787303	56787303	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcgtactcggttattaaaTggcctagcccagcaaatgat	11	12	8	10	2	0	1	0	1	0	0	2	1	0	1	2	2	3	3	2	2	6	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr17:56787303T>C	uc002iwu.2	+	5	831	c.789T>C	c.(787-789)AAT>AAC	p.N263N	RAD51C_uc010woa.1_Silent_p.N263N|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	263					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGTTATTAAATGGCCTAGCCC	0.373								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				30	153					0	0	0	0	C	56787303	C	C	56787303	2	2	248	1	0	0	0	0	0	0	0	1	13053	1461	51	5		5	RAD51C	17	56787303	Silent	SNP	T	TCGA-CV-7409-01A-31D-2229-08	15819375	56787303	24407907	233	45668											
ABCA9	10350	broad.mit.edu	37	chr17	66978735	66978735	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaagaaagcctgtgataaaGgtcgcacatcctcaacaggc	14	7	10	10	1	1	3	1	2	0	1	3	3	2	3	2	2	2	1	2	2	5	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr17:66978735G>A	uc002jhu.2	-	37	4831	c.4688C>T	c.(4687-4689)CCT>CTT	p.P1563L	ABCA9_uc010dez.2_Missense_Mutation_p.P1525L	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1563					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CTGTGATAAAGGTCGCACATC	0.448													67	42					0	0	0	0	A	66978735	A	A	66978735	3	1	248	1	0	0	0	0	1	0	0	0	39	1000	35	4	198	4	ABCA9	17	66978735	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	10191432	66978735	14216475	234	45669											
KIF19	124602	broad.mit.edu	37	chr17	72350935	72350935	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacagctctcccaccccaaGacacacctcctggggcccca	9	5	6	21	0	2	1	1	0	1	1	4	1	3	1	7	2	1	1	7	2	1	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr17:72350935G>C	uc002jkm.3	+	19	2859	c.2721G>C	c.(2719-2721)AAG>AAC	p.K907N		NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	907					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						CCCACCCCAAGACACACCTCC	0.627													4	1					0	0	0	0	C	72350935	C	C	72350935	3	2	248	1	0	0	0	0	1	0	0	0	8321	933	33	2	2795	2	KIF19	17	72350935	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	5372200	72350935	8844275	235	45670											
CCDC57	284001	broad.mit.edu	37	chr17	80173535	80173535	+	5'Flank	DEL	C	-	-																															cccctccccttccttccctgCcccccacactgcagcacccc																								rs112012232		TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr17:80173535delC	uc002kdz.1	-						CCDC57_uc002kdx.1_5'Flank	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57											ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			tccttccctgccccccacact	0.313													---	---	---								-	80173535	-	-	80173535	6	5	248	0	1	1	0	1	0	0	0	0	2840	754	26	0		0	CCDC57	17	80173535	5'Flank	DEL	C	TCGA-CV-7409-01A-31D-2229-08	7822600	80173535	1021675	236	45671											
PTPRM	5797	broad.mit.edu	37	chr18	7955293	7955293	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccagtcgattccacgagctAtaaaattggacaccttgacc	12	9	8	12	2	0	1	0	1	0	0	2	4	1	2	4	1	1	1	4	1	3	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:7955293A>G	uc002knn.3	+	7	1516	c.1013A>G	c.(1012-1014)TAT>TGT	p.Y338C	PTPRM_uc010dkv.2_Missense_Mutation_p.Y338C|PTPRM_uc010wzl.1_Missense_Mutation_p.Y125C	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	338	Fibronectin type-III 1.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				TCCACGAGCTATAAAATTGGA	0.572													20	55					0	0	0	0	G	7955293	G	G	7955293	3	3	248	1	0	0	0	0	1	0	0	0	12871	449	16	5	1039	5	PTPRM	18	7955293	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08		7955293	70121955	237	45672											
MC2R	4158	broad.mit.edu	37	chr18	13885460	13885460	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caaaaccacacgaggacagtCggaattatttcttgctgtgt	12	11	9	9	2	1	0	0	0	1	0	2	3	1	2	1	2	2	1	1	2	4	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:13885460C>T	uc002ksp.1	-	2	235	c.58G>A	c.(58-60)GAC>AAC	p.D20N		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	20	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	CGAGGACAGTCGGAATTATTT	0.418													15	36					0	0	0	0	T	13885460	T	T	13885460	3	4	248	1	0	0	0	0	1	0	0	0	9417	884	31	1	839	1	MC2R	18	13885460	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	5930167	13885460	64191788	238	45673											
MAPRE2	10982	broad.mit.edu	37	chr18	32682063	32682063	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atgcaattcctcctcctgacCctggtgaacagatcttcaac	10	11	6	14	0	2	3	1	2	1	1	5	3	5	3	4	1	3	1	4	1	3	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:32682063C>T	uc002kyg.2	+	4	730	c.550C>T	c.(550-552)CCT>TCT	p.P184S	MAPRE2_uc010xcb.1_Missense_Mutation_p.P141S|MAPRE2_uc010xcc.1_Missense_Mutation_p.P172S|MAPRE2_uc002kyf.2_Missense_Mutation_p.P184S|MAPRE2_uc002kyh.2_Missense_Mutation_p.P131S|MAPRE2_uc010xcd.1_Missense_Mutation_p.P141S	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	184					cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						TCCTCCTGACCCTGGTGAACA	0.448													12	55					0	0	0	0	T	32682063	T	T	32682063	3	4	248	1	0	0	0	0	1	0	0	0	9348	623	22	4	658	4	MAPRE2	18	32682063	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	18796603	32682063	45395185	239	45674											
TCEB3B	51224	broad.mit.edu	37	chr18	44559812	44559812	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggggcgtccggaagccgcagGtactgctccctccaagtttt	6	9	13	13	3	0	0	0	0	0	0	3	1	3	1	4	4	3	4	4	4	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:44559812G>T	uc002lcr.1	-	1	2177	c.1824C>A	c.(1822-1824)TAC>TAA	p.Y608*	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	608	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GAAGCCGCAGGTACTGCTCCC	0.512													24	98					7.76418e-22	9.91238e-22	1	0	T	44559812	T	T	44559812	4	4	248	1	0	0	0	0	0	1	0	0	15748	1256	44	4	441	4	TCEB3B	18	44559812	Nonsense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	11877749	44559812	33517436	240	45675											
MBD1	4152	broad.mit.edu	37	chr18	47806253	47806253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccactacccacccagtacCtctggtaataggtgtctgag	9	9	9	14	0	2	1	0	1	2	0	2	1	2	1	4	2	2	2	4	2	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:47806253C>T	uc010dow.1	-	2	547	c.110G>A	c.(109-111)AGC>AAC	p.S37N	MBD1_uc002lef.2_5'Flank|MBD1_uc002leg.2_Missense_Mutation_p.S37N|MBD1_uc010xdi.1_Missense_Mutation_p.S63N|MBD1_uc002leh.3_Missense_Mutation_p.S37N|MBD1_uc002len.2_Missense_Mutation_p.S37N|MBD1_uc002lei.3_Missense_Mutation_p.S37N|MBD1_uc002lej.3_Missense_Mutation_p.S37N|MBD1_uc002lek.3_Missense_Mutation_p.S37N|MBD1_uc002lel.3_Missense_Mutation_p.S37N|MBD1_uc002lem.3_Missense_Mutation_p.S37N|MBD1_uc010xdj.1_Missense_Mutation_p.S37N|MBD1_uc010xdk.1_Missense_Mutation_p.S37N|MBD1_uc010dox.1_Missense_Mutation_p.S37N|MBD1_uc002leo.2_Missense_Mutation_p.S37N	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	37	MBD.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CACCCAGTACCTCTGGTAATA	0.542													26	71					0	0	0	0	T	47806253	T	T	47806253	3	4	248	1	0	0	0	0	1	0	0	0	9395	695	24	4	1961	4	MBD1	18	47806253	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	3246441	47806253	30270995	241	45676											
DCC	1630	broad.mit.edu	37	chr18	50432616	50432616	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atcagccgactccaaccgggGgacattggaatttaccgatg	11	8	11	11	3	1	0	1	0	0	0	2	4	2	2	4	3	3	0	4	3	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:50432616G>T	uc002lfe.1	+	3	1202	c.615G>T	c.(613-615)GGG>GGT	p.G205G	DCC_uc010xdr.1_Silent_p.G53G	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	205	Extracellular (Potential).|Ig-like C2-type 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCCAACCGGGGGACATTGGAA	0.502													13	53					1.52009e-12	1.80511e-12	1	0	T	50432616	T	T	50432616	2	4	248	1	0	0	0	0	0	0	0	1	4299	1219	43	4		4	DCC	18	50432616	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	2626363	50432616	27644632	242	45677											
DCC	1630	broad.mit.edu	37	chr18	50832003	50832003	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aacacaaaatggatttattaCcggctataaaattcgacaca	18	10	5	8	2	0	0	0	0	0	0	1	2	0	1	1	2	2	1	1	2	8	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:50832003C>A	uc002lfe.1	+	13	2554	c.1967C>A	c.(1966-1968)ACC>AAC	p.T656N	DCC_uc010xdr.1_Missense_Mutation_p.T504N|DCC_uc010dpf.1_Missense_Mutation_p.T311N	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	656	Extracellular (Potential).|Fibronectin type-III 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GGATTTATTACCGGCTATAAA	0.413													18	55					1.28384e-07	1.4057e-07	1	0	A	50832003	A	A	50832003	3	1	248	1	0	0	0	0	1	0	0	0	4299	507	18	4	2017	4	DCC	18	50832003	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	399387	50832003	27245245	243	45678											
DCC	1630	broad.mit.edu	37	chr18	50848513	50848513	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatactgcagagactccagAgaatgatctagatggtaaga	15	9	11	6	0	1	5	0	1	1	4	2	7	2	5	1	1	2	3	1	1	5	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:50848513A>T	uc002lfe.1	+	14	2737	c.2150A>T	c.(2149-2151)GAG>GTG	p.E717V	DCC_uc010xdr.1_Missense_Mutation_p.E565V|DCC_uc010dpf.1_Missense_Mutation_p.E372V	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	717	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GAGACTCCAGAGAATGATCTA	0.418													15	36					0	0	0	0	T	50848513	T	T	50848513	3	4	248	1	0	0	0	0	1	0	0	0	4299	304	11	5	2204	5	DCC	18	50848513	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	16510	50848513	27228735	244	45679											
CDH19	28513	broad.mit.edu	37	chr18	64172293	64172293	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaatttcctgaatatggcaCtgtcggggccaacttgcaaa	11	11	10	9	1	0	2	0	2	0	0	2	2	1	2	2	3	2	2	2	3	5	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:64172293C>G	uc002lkc.1	-	12	2213	c.2075G>C	c.(2074-2076)AGT>ACT	p.S692T	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	692	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				GAATATGGCACTGTCGGGGCC	0.498													19	61					0	0	0	0	G	64172293	G	G	64172293	3	3	248	1	0	0	0	0	1	0	0	0	3119	565	20	4	247	4	CDH19	18	64172293	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	13323780	64172293	13904955	245	45680											
DOK6	220164	broad.mit.edu	37	chr18	67231740	67231740	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cagattttcagacgatgctgGttggttttcaagaaggcttc	9	14	11	7	1	2	3	2	0	0	3	3	4	2	3	0	3	1	4	0	3	2	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:67231740G>T	uc002lkl.2	+	2	274	c.84G>T	c.(82-84)TGG>TGT	p.W28C		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	28	PH.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GACGATGCTGGTTGGTTTTCA	0.338													8	27					3.86212e-05	4.02408e-05	1	0	T	67231740	T	T	67231740	3	4	248	1	0	0	0	0	1	0	0	0	4723	1270	44	4	90	4	DOK6	18	67231740	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	3059447	67231740	10845508	246	45681											
SALL3	27164	broad.mit.edu	37	chr18	76754599	76754599	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtccgtggagaacgggtccGgggagagtgaccgcctgagc	8	5	18	10	4	0	4	0	2	0	2	2	6	2	4	4	4	2	0	4	4	1	0	rs146129529		TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:76754599G>T	uc002lmt.2	+	2	2608	c.2608G>T	c.(2608-2610)GGG>TGG	p.G870W	SALL3_uc010dra.2_Missense_Mutation_p.G477W	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GAACGGGTCCGGGGAGAGTGA	0.667													20	55					1.10923e-09	1.2705e-09	1	0	T	76754599	T	T	76754599	3	4	248	1	0	0	0	0	1	0	0	0	13877	1116	39	3	2614	3	SALL3	18	76754599	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	9522859	76754599	1322649	247	45682											
ATP9B	374868	broad.mit.edu	37	chr18	76829442	76829442	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatcccgctttacccggtgcGtagcgcagcggcggccgcag	5	6	15	15	7	0	0	0	0	0	0	1	1	1	0	3	3	4	4	3	3	2	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr18:76829442G>T	uc002lmx.2	+	1	46	c.32G>T	c.(31-33)CGT>CTT	p.R11L	ATP9B_uc002lmv.1_RNA|ATP9B_uc002lmw.1_Missense_Mutation_p.R11L|ATP9B_uc002lmu.2_Missense_Mutation_p.R11L	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	11	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		TACCCGGTGCGTAGCGCAGCG	0.711													4	9					0.00024832	0.000257075	1	0	T	76829442	T	T	76829442	3	4	248	1	0	0	0	0	1	0	0	0	1201	1145	40	3	34	3	ATP9B	18	76829442	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	74843	76829442	1247806	248	45683											
GRIN3B	116444	broad.mit.edu	37	chr19	1005351	1005351	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaccgtcttctcctactcCtcagccctcaacctgtgcta	7	11	5	18	1	4	0	2	0	2	0	6	0	5	0	5	0	5	2	5	0	3	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:1005351C>A	uc002lqo.1	+	3	1851	c.1851C>A	c.(1849-1851)TCC>TCA	p.S617S		NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	617	Cytoplasmic (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	TCTCCTACTCCTCAGCCCTCA	0.657													55	127					7.91745e-34	1.1023e-33	1	0	A	1005351	A	A	1005351	2	1	248	1	0	0	0	0	0	0	0	1	6823	668	24	4		4	GRIN3B	19	1005351	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08		1005351	58123632	249	45684											
FEM1A	55527	broad.mit.edu	37	chr19	4792850	4792850	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggcgggccatggagctGcgtcaccaggggggcgagta	7	5	20	9	3	1	0	1	0	0	0	1	3	1	2	2	7	2	2	2	7	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:4792850G>A	uc002mbf.2	+	1	1123	c.984G>A	c.(982-984)CTG>CTA	p.L328L	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	328	TPR 1.				regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CCATGGAGCTGCGTCACCAGG	0.602													22	64					0	0	0	0	A	4792850	A	A	4792850	2	1	248	1	0	0	0	0	0	0	0	1	5841	1306	46	4		4	FEM1A	19	4792850	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	3787499	4792850	54336133	250	45685											
MUC16	94025	broad.mit.edu	37	chr19	9066714	9066714	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccattggagctgtggccttgGttttttctgagtcagctagg	5	15	13	8	0	2	1	1	1	1	0	2	2	2	2	2	4	2	3	2	4	1	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:9066714G>T	uc002mkp.2	-	3	20936	c.20732C>A	c.(20731-20733)ACC>AAC	p.T6911N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6913	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTGGCCTTGGTTTTTTCTGA	0.478													50	209					5.99346e-17	7.38888e-17	1	0	T	9066714	T	T	9066714	3	4	248	1	0	0	0	0	1	0	0	0	10026	1261	44	4	23119	4	MUC16	19	9066714	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	4273864	9066714	50062269	251	45686											
ZNF560	147741	broad.mit.edu	37	chr19	9580305	9580305	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgttcttcacaaacactcaCcttggagaactcttggcagt	10	13	7	11	0	4	1	2	0	2	1	4	2	4	1	1	2	2	2	1	2	2	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:9580305C>T	uc002mlp.1	-	8	739	c.529_splice	c.e8+1	p.E177_splice	ZNF560_uc010dwr.1_Splice_Site_p.E71_splice	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						CAAACACTCACCTTGGAGAAC	0.458													11	42					0	0	0	0	T	9580305	T	T	9580305	5	4	248	1	0	0	0	0	0	0	1	0	18058	521	18	4	1854	4	ZNF560	19	9580305	Splice_Site	SNP	C	TCGA-CV-7409-01A-31D-2229-08	513591	9580305	49548678	252	45687											
ZNF136	7695	broad.mit.edu	37	chr19	12296670	12296670	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctttgctagatccttcccAgaagaatctctacagagatg	11	11	9	10	0	1	4	0	0	1	4	4	5	3	4	2	1	2	2	2	1	4	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:12296670A>T	uc002mti.2	+	2	174	c.74A>T	c.(73-75)CAG>CTG	p.Q25L	ZNF136_uc010xmh.1_Intron	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	25	KRAB.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						GATCCTTCCCAGAAGAATCTC	0.448													29	50					0	0	0	0	T	12296670	T	T	12296670	3	4	248	1	0	0	0	0	1	0	0	0	17793	188	7	5	80	5	ZNF136	19	12296670	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	2716365	12296670	46832313	253	45688											
NWD1	284434	broad.mit.edu	37	chr19	16860954	16860955	+	Missense_Mutation	DNP	CA	AG	AG																															ccctttccggaaaccaaggcCagcagatgatccaactcctg																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:16860954_16860955CA>AG	uc002neu.3	+	6	1923_1924	c.1501_1502CA>AG	c.(1501-1503)CAG>AGG	p.Q501R	NWD1_uc002net.3_Missense_Mutation_p.Q366R|NWD1_uc002nev.3_Missense_Mutation_p.Q295R			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	501	NACHT.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						AAACCAAGGCCAGCAGATGATC	0.639													34	89					0	0	0	0	AG	16860955	AG	AG	16860954	3	1	248	1	0	0	0	0	1	0	0	0	10835	595	21	4	1102	4	NWD1	19	16860954	Missense_Mutation	DNP	CA	TCGA-CV-7409-01A-31D-2229-08	4564284	16860954	42268029	254	45689											
UNC13A	23025	broad.mit.edu	37	chr19	17768873	17768873	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactccgcagcacctacctGagggcttgtggctcagagaa	9	7	12	13	1	1	2	1	1	0	1	2	3	2	2	3	2	2	5	3	2	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:17768873G>T	uc002nhd.2	-	10	1029	c.1029C>A	c.(1027-1029)CTC>CTA	p.L343L		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	255					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GCACCTACCTGAGGGCTTGTG	0.602													14	28					6.31663e-08	7.05976e-08	1	0	T	17768873	T	T	17768873	2	4	248	1	0	0	0	0	0	0	0	1	17052	1277	45	2		2	UNC13A	19	17768873	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	907919	17768873	41360110	255	45690											
ZNF708	7562	broad.mit.edu	37	chr19	21477072	21477072	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agagttgaggactggttaaaAgcttttccacattcttcaca	12	13	8	8	0	2	2	1	1	1	1	3	3	3	3	1	2	1	3	1	2	2	6			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:21477072A>G	uc002npq.1	-	4	894	c.696T>C	c.(694-696)GCT>GCC	p.A232A	ZNF708_uc002npr.1_Silent_p.A168A|ZNF708_uc010ecs.1_Silent_p.A168A	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	232	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						ACTGGTTAAAAGCTTTTCCAC	0.358													10	17					0	0	0	0	G	21477072	G	G	21477072	2	3	248	1	0	0	0	0	0	0	0	1	18179	59	3	5		5	ZNF708	19	21477072	Silent	SNP	A	TCGA-CV-7409-01A-31D-2229-08	3708199	21477072	37651911	256	45691											
THAP8	199745	broad.mit.edu	37	chr19	36530944	36530944	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcaggagggtgtgaagtgctCgctgcacaagtgctggtggc	7	8	18	8	1	0	1	0	1	0	0	1	2	0	2	0	4	3	5	0	4	2	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:36530944C>G	uc002oda.1	-	2	723	c.178G>C	c.(178-180)GAG>CAG	p.E60Q	uc002ocy.2_Intron|THAP8_uc010xtb.1_Missense_Mutation_p.E17Q|THAP8_uc010xtc.1_Intron	NM_152658	NP_689871	Q8NA92	THAP8_HUMAN	THAP domain containing 8	60	THAP-type.						DNA binding|metal ion binding				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GTGAAGTGCTCGCTGCACAAG	0.652													18	55					0	0	0	0	G	36530944	G	G	36530944	3	3	248	1	0	0	0	0	1	0	0	0	15916	893	31	3	658	3	THAP8	19	36530944	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	15053872	36530944	22598039	257	45692											
CYP2A7	1549	broad.mit.edu	37	chr19	41388039	41388039	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttccccctgctcttcctcTgctgccagacagacatcaag	7	10	7	17	0	3	2	1	0	2	2	5	2	5	2	4	0	3	3	4	0	1	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:41388039T>A	uc002opm.2	-	1	619	c.77A>T	c.(76-78)CAG>CTG	p.Q26L	CYP2A7_uc002opo.2_Intron|CYP2A7_uc002opn.2_Missense_Mutation_p.Q26L	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	26						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GCTCTTCCTCTGCTGCCAGAC	0.572													52	72					0	0	0	0	A	41388039	A	A	41388039	3	1	248	1	0	0	0	0	1	0	0	0	4180	1580	55	5	1453	5	CYP2A7	19	41388039	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	4857095	41388039	17740944	258	45693											
AXL	558	broad.mit.edu	37	chr19	41754431	41754431	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcatgcagtgaacagcctggGcatcagtgaagagctgaagg	12	6	15	8	0	1	4	1	3	0	1	1	4	1	4	1	2	4	4	1	2	3	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:41754431G>A	uc010ehj.2	+	13	1740	c.1550G>A	c.(1549-1551)GGC>GAC	p.G517D	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehk.2_Missense_Mutation_p.G508D	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	517	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						AACAGCCTGGGCATCAGTGAA	0.453													51	131					0	0	0	0	A	41754431	A	A	41754431	3	1	248	1	0	0	0	0	1	0	0	0	1240	1203	42	4	1600	4	AXL	19	41754431	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	366392	41754431	17374552	259	45694											
GRIK5	2901	broad.mit.edu	37	chr19	42563568	42563568	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtggacaccttgtcatcaCggatctccttgagcagtggt	7	12	12	10	1	3	1	2	1	1	0	4	3	3	3	2	4	1	1	2	4	0	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:42563568C>A	uc002osj.1	-	5	655	c.620G>T	c.(619-621)CGT>CTT	p.R207L	GRIK5_uc010eib.1_Missense_Mutation_p.R126L	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	207	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CTTGTCATCACGGATCTCCTT	0.572													33	130					2.66277e-13	3.1737e-13	1	0	A	42563568	A	A	42563568	3	1	248	1	0	0	0	0	1	0	0	0	6816	536	19	3	2382	3	GRIK5	19	42563568	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	809137	42563568	16565415	260	45695											
PSG5	5673	broad.mit.edu	37	chr19	43680053	43680053	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtgactgggtcactgcgCatgccaccatctcggtcccg	6	8	13	14	3	2	1	1	1	1	0	4	1	3	1	3	3	2	1	3	3	0	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:43680053C>G	uc002ovu.2	-	3	809	c.678G>C	c.(676-678)ATG>ATC	p.M226I	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Intron|PSG5_uc002ovx.2_Missense_Mutation_p.M226I|PSG5_uc002ovv.2_Missense_Mutation_p.M319I|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	226	Ig-like C2-type 1.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				GGTCACTGCGCATGCCACCAT	0.488													55	162					0	0	0	0	G	43680053	G	G	43680053	3	3	248	1	0	0	0	0	1	0	0	0	12720	710	25	4	341	4	PSG5	19	43680053	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	1116485	43680053	15448930	261	45696											
PSG9	5678	broad.mit.edu	37	chr19	43772208	43772210	+	In_Frame_Del	DEL	AGA	-	-																															ggggcaaattgtggacaagtAgaagaacatccttcccctca																								rs144736946		TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:43772208_43772210delAGA	uc002owd.3	-	2	255_257	c.156_158delTCT	c.(154-159)CTTCTA>CTA	p.52_53LL>L	PSG9_uc002owe.3_In_Frame_Del_p.52_53LL>L|PSG9_uc010xwm.1_In_Frame_Del_p.52_53LL>L|PSG9_uc002owf.3_In_Frame_Del_p.52_53LL>L|PSG9_uc002owg.2_In_Frame_Del_p.52_53LL>L|PSG9_uc002owh.2_In_Frame_Del_p.52_53LL>L	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	52_53	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				GTGGACAAGTAGAAGAACATCCT	0.473													---	---	---								-	43772210	-	-	43772208	7	5	248	1	0	1	0	1	0	0	0	0	12724	420	15	0	1142	0	PSG9	19	43772208	In_Frame_Del	DEL	AGA	TCGA-CV-7409-01A-31D-2229-08	92155	43772208	15356775	262	45697											
ZNF222	7673	broad.mit.edu	37	chr19	44536355	44536356	+	Frame_Shift_Del	DEL	TG	-	-																															gtgaaatgctataagtgtgaTgtgtgtggtaaggaatttag																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:44536355_44536356delTG	uc002oyc.2	+	4	711_712	c.528_529delTG	c.(526-531)GATGTGfs	p.D176fs	ZNF284_uc010ejd.2_Intron|ZNF222_uc002oye.2_Frame_Shift_Del_p.D216fs|ZNF222_uc002oyd.2_Frame_Shift_Del_p.D122fs	NM_013360	NP_037492	Q9UK12	ZN222_HUMAN	zinc finger protein 222 isoform 2	176_177	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Prostate(69;0.0435)				ATAAGTGTGATGTGTGTGGTAA	0.441													---	---	---								-	44536356	-	-	44536355	7	5	248	1	0	1	0	1	0	0	0	0	17843	1461	51	0	681	0	ZNF222	19	44536355	Frame_Shift_Del	DEL	TG	TCGA-CV-7409-01A-31D-2229-08	764147	44536355	14592628	263	45698											
ZNF225	7768	broad.mit.edu	37	chr19	44635982	44635982	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acattcaaatgtgaagaatgTgggaagggattttatacaaa	17	11	10	3	0	1	2	1	1	0	1	1	4	1	4	0	2	1	0	0	2	7	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:44635982T>A	uc002oyj.1	+	5	1458	c.1215T>A	c.(1213-1215)TGT>TGA	p.C405*	ZNF225_uc010eje.1_Nonsense_Mutation_p.C322*|ZNF225_uc010ejf.1_Nonsense_Mutation_p.C405*	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	405	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				GTGAAGAATGTGGGAAGGGAT	0.428													52	92					0	0	0	0	A	44635982	A	A	44635982	4	1	248	1	0	0	0	0	0	1	0	0	17846	1702	59	5	1229	5	ZNF225	19	44635982	Nonsense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	99627	44635982	14493001	264	45699											
CGB2	114336	broad.mit.edu	37	chr19	49536447	49536447	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagcccatcccgactcccggGgccctcagacaccccgatcc	8	4	8	21	3	1	1	1	0	0	1	4	3	4	1	7	2	1	0	7	2	1	0			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:49536447G>T	uc002plw.2	+	3	684	c.461G>T	c.(460-462)GGG>GTG	p.G154V	CGB_uc010yad.1_Intron|SNAR-G2_uc010yae.1_5'Flank|CGB2_uc010yaf.1_Missense_Mutation_p.G142V|CGB2_uc010yag.1_Missense_Mutation_p.G142V	NM_033378	NP_203696			chorionic gonadotropin, beta polypeptide 2												0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		CGACTCCCGGGGCCCTCAGAC	0.632													37	100					1.35996e-42	1.98763e-42	1	0	T	49536447	T	T	49536447	3	4	248	1	0	0	0	0	1	0	0	0	3313	1232	43	4	471	4	CGB2	19	49536447	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	4900465	49536447	9592536	265	45700											
C19orf73	55150	broad.mit.edu	37	chr19	49622086	49622086	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgaaccattagcctcgtcCgccgggggaaccctgcaggc	8	5	13	15	4	0	0	0	0	0	0	2	2	1	1	5	3	5	1	5	3	3	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:49622086C>A	uc002pmq.3	-	1	312	c.194G>T	c.(193-195)CGG>CTG	p.R65L	PPFIA3_uc002pmr.2_5'Flank|PPFIA3_uc010yai.1_5'Flank	NM_018111	NP_060581	Q9NVV2	CS073_HUMAN	hypothetical protein LOC55150	65										large_intestine(1)	1						TAGCCTCGTCCGCCGGGGGAA	0.701													32	62					5.6714e-07	6.12663e-07	1	0	A	49622086	A	A	49622086	3	1	248	1	0	0	0	0	1	0	0	0	1957	652	23	3	199	3	C19orf73	19	49622086	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	85639	49622086	9506897	266	45701											
ZNF419	79744	broad.mit.edu	37	chr19	58005445	58005445	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acatcgaaggattcacactgGagaaatgcagtgattgtgtg	13	10	12	6	1	1	2	1	1	0	1	2	5	1	3	0	2	1	1	0	2	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr19:58005445G>T	uc002qov.2	+	5	1760	c.1520G>T	c.(1519-1521)GGA>GTA	p.G507V	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Missense_Mutation_p.G508V|ZNF419_uc010etz.1_Missense_Mutation_p.G495V|ZNF419_uc010eua.1_Missense_Mutation_p.G494V|ZNF419_uc002qow.2_Missense_Mutation_p.G475V|ZNF419_uc010eub.1_Missense_Mutation_p.G462V|ZNF419_uc010euc.1_Missense_Mutation_p.G461V	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		ATTCACACTGGAGAAATGCAG	0.428													28	68					2.49534e-26	3.28978e-26	1	0	T	58005445	T	T	58005445	3	4	248	1	0	0	0	0	1	0	0	0	17963	1174	41	2	1541	2	ZNF419	19	58005445	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	8383359	58005445	1123538	267	45702											
SSTR4	6754	broad.mit.edu	37	chr20	23017157	23017157	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaggaggagcccctggactActatgccactgctctcaaga	10	8	11	12	0	1	2	1	1	1	1	2	5	1	5	3	3	4	1	3	3	3	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr20:23017157A>C	uc002wsr.2	+	1	1101	c.1037A>C	c.(1036-1038)TAC>TCC	p.Y346S		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	346	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCCCTGGACTACTATGCCACT	0.642													43	58					0	0	0	0	C	23017157	C	C	23017157	3	2	248	1	0	0	0	0	1	0	0	0	15266	391	14	5	1039	5	SSTR4	20	23017157	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08		23017157	40008363	268	45703											
SLC12A5	57468	broad.mit.edu	37	chr20	44686242	44686242	+	Nonstop_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcatcaccatctactccTgagaaccaggacctgccacc	11	7	7	16	0	3	1	2	1	1	1	4	3	4	2	6	2	3	0	6	2	2	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr20:44686242T>A	uc010zxl.1	+	26	3494	c.3418T>A	c.(3418-3420)TGA>AGA	p.*1140R	SLC12A5_uc002xrb.2_Nonstop_Mutation_p.*1117R	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	1140					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CATCTACTCCTGAGAACCAGG	0.433													80	65					0	0	0	0	A	44686242	A	A	44686242	4	1	248	1	0	0	0	0	0	0	0	0	14451	1593	55	5	3576	5	SLC12A5	20	44686242	Nonstop_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	21669085	44686242	18339278	269	45704											
DIDO1	11083	broad.mit.edu	37	chr20	61512638	61512638	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcctgccgggggtccctgTggtttgacgcctggctggcg	1	10	17	13	4	0	1	0	1	0	0	2	1	1	1	4	5	1	2	4	5	0	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr20:61512638T>C	uc002ydr.1	-	16	4934	c.4670A>G	c.(4669-4671)CAC>CGC	p.H1557R	DIDO1_uc002yds.1_Missense_Mutation_p.H1557R	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1557					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GGGGTCCCTGTGGTTTGACGC	0.692													88	77					0	0	0	0	C	61512638	C	C	61512638	3	2	248	1	0	0	0	0	1	0	0	0	4544	1696	59	5	2056	5	DIDO1	20	61512638	Missense_Mutation	SNP	T	TCGA-CV-7409-01A-31D-2229-08	16826396	61512638	1512882	270	45705											
ANKRD54	129138	broad.mit.edu	37	chr22	38228672	38228672	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtactggtcatctgcaggCgggtgcagaggtcatccagg	7	9	16	9	1	3	1	2	0	1	1	4	1	4	1	1	6	3	3	1	6	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr22:38228672C>T	uc003auc.2	-	7	858	c.800G>A	c.(799-801)CGC>CAC	p.R267H	ANKRD54_uc003aud.2_Missense_Mutation_p.R144H	NM_138797	NP_620152	Q6NXT1	ANR54_HUMAN	ankyrin repeat domain 54	267											0	Melanoma(58;0.045)					CATCTGCAGGCGGGTGCAGAG	0.617													17	51					0	0	0	0	T	38228672	T	T	38228672	3	4	248	1	0	0	0	0	1	0	0	0	680	768	27	1	110	1	ANKRD54	22	38228672	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08		38228672	13075894	271	45706											
NAGA	4668	broad.mit.edu	37	chr22	42461771	42461771	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcattccagtgcccagggcCggccactggctgcagtatgt	6	9	13	13	1	1	0	1	0	0	0	2	0	2	0	4	3	2	3	4	3	1	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr22:42461771C>A	uc003bbx.2	-	7	867	c.730G>T	c.(730-732)GGC>TGC	p.G244C	NAGA_uc003bby.2_Missense_Mutation_p.G244C|NAGA_uc003bbw.3_Missense_Mutation_p.G244C	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	244					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						TGCCCAGGGCCGGCCACTGGC	0.602													20	46					1.66031e-10	1.90846e-10	1	0	A	42461771	A	A	42461771	3	1	248	1	0	0	0	0	1	0	0	0	10194	652	23	3	521	3	NAGA	22	42461771	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	4233099	42461771	8842795	272	45707											
KLHDC7B	113730	broad.mit.edu	37	chr22	50987549	50987549	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcccctgtgtccctgcctctAcctgcgcacctgcatgtgtt	3	12	9	17	1	1	0	0	0	1	0	2	0	2	0	6	0	4	3	6	0	1	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chr22:50987549A>G	uc003bmi.2	+	1	1088	c.954A>G	c.(952-954)CTA>CTG	p.L318L		NM_138433	NP_612442	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	318	Kelch 1.									central_nervous_system(1)	1		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCCTGCCTCTACCTGCGCACC	0.721													56	80					0	0	0	0	G	50987549	G	G	50987549	2	3	248	1	0	0	0	0	0	0	0	1	8400	378	14	5		5	KLHDC7B	22	50987549	Silent	SNP	A	TCGA-CV-7409-01A-31D-2229-08	8525778	50987549	317017	273	45708											
ASMTL	8623	broad.mit.edu	37	chrX	1540721	1540721	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggtagacgttcgctgtctCtgtgttactgtaacctggag	7	13	12	9	2	1	1	0	0	1	1	3	2	1	2	1	2	2	5	1	2	3	4			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:1540721C>G	uc004cpx.1	-	9	1186	c.1075G>C	c.(1075-1077)GAG>CAG	p.E359Q	ASMTL_uc011mhe.1_Missense_Mutation_p.E283Q|ASMTL_uc004cpy.1_Missense_Mutation_p.E343Q|ASMTL_uc011mhf.1_Missense_Mutation_p.E301Q	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	359	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTCGCTGTCTCTGTGTTACTG	0.478													32	149					0	0	0	0	G	1540721	G	G	1540721	3	3	248	1	0	0	0	0	1	0	0	0	1048	922	32	2	810	2	ASMTL	23	1540721	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08		1540721	153729839	274	45709											
DCAF8L1	139425	broad.mit.edu	37	chrX	27998998	27998998	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggacttgccagcgagatcGgggcagggcagatgtctctg	9	7	16	9	2	1	2	0	0	1	2	3	4	1	3	1	4	2	2	1	4	1	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:27998998G>C	uc004dbx.1	-	1	569	c.454C>G	c.(454-456)CGA>GGA	p.R152G		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	152										ovary(3)|skin(1)	4						CAGCGAGATCGGGGCAGGGCA	0.567													6	8					0	0	0	0	C	27998998	C	C	27998998	3	2	248	1	0	0	0	0	1	0	0	0	4294	1124	39	3	1352	3	DCAF8L1	23	27998998	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	26458277	27998998	127271562	275	45710											
MAGEB3	4114	broad.mit.edu	37	chrX	30254871	30254871	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgaattcctgtggggtcCaagagcccatgctgaaacca	11	9	10	11	0	0	3	0	2	0	1	2	3	2	3	4	2	3	1	4	2	4	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:30254871C>G	uc004dca.1	+	5	1567	c.830C>G	c.(829-831)CCA>CGA	p.P277R		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	277	MAGE.										0						CTGTGGGGTCCAAGAGCCCAT	0.498													11	14					0	0	0	0	G	30254871	G	G	30254871	3	3	248	1	0	0	0	0	1	0	0	0	9230	594	21	4	832	4	MAGEB3	23	30254871	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	2255873	30254871	125015689	276	45711											
CXorf59	286464	broad.mit.edu	37	chrX	36122661	36122661	+	Frame_Shift_Del	DEL	C	-	-																															catactgcagcaataatatgCcccccatatgtgtgcaaaat																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:36122661delC	uc004ddk.1	+	8	1084	c.898delC	c.(898-900)CCCfs	p.P300fs		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	300						integral to membrane				central_nervous_system(1)	1						CAATAATATGCCCCCCATATG	0.353													---	---	---								-	36122661	-	-	36122661	7	5	248	1	0	1	0	1	0	0	0	0	4132	739	26	0	924	0	CXorf59	23	36122661	Frame_Shift_Del	DEL	C	TCGA-CV-7409-01A-31D-2229-08	5867790	36122661	119147899	277	45712											
FAM47C	442444	broad.mit.edu	37	chrX	37026872	37026873	+	Missense_Mutation	DNP	CC	GA	GA																															ccagctgatgaccaagcatcCcttggccatgtaccccaatc																										TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:37026872_37026873CC>GA	uc004ddl.1	+	1	403_404	c.389_390CC>GA	c.(388-390)CCC>CGA	p.P130R		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	130										ovary(3)	3						ACCAAGCATCCCTTGGCCATGT	0.569													20	18					0	0	0	0	GA	37026873	GA	GA	37026872	3	3	248	1	0	0	0	0	1	0	0	0	5603	623	22	4	391	4	FAM47C	23	37026872	Missense_Mutation	DNP	CC	TCGA-CV-7409-01A-31D-2229-08	904211	37026872	118243688	278	45713											
ZNF81	347344	broad.mit.edu	37	chrX	47775780	47775780	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcagagaattcatactacaGagaagccttataaatgtcct	16	11	6	8	0	2	2	2	0	0	2	3	4	3	2	2	0	3	0	2	0	7	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:47775780G>T	uc010nhy.1	+	6	2103	c.1735G>T	c.(1735-1737)GAG>TAG	p.E579*		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	579						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				TCATACTACAGAGAAGCCTTA	0.418													12	8					1.5842e-08	1.78915e-08	1	0	T	47775780	T	T	47775780	4	4	248	1	0	0	0	0	0	1	0	0	18241	943	33	2	1749	2	ZNF81	23	47775780	Nonsense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	10748908	47775780	107494780	279	45714											
KDM5C	8242	broad.mit.edu	37	chrX	53239927	53239927	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaaaggctgagaagaccatgCccacgtagagccagggcacc	14	3	12	12	1	0	3	0	1	0	3	0	4	0	3	4	2	2	3	4	2	4	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:53239927C>A	uc004drz.2	-	11	2047	c.1514G>T	c.(1513-1515)GGC>GTC	p.G505V	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Missense_Mutation_p.G438V|KDM5C_uc004dsa.2_Missense_Mutation_p.G504V	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	505	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						GAAGACCATGCCCACGTAGAG	0.517			N|F|S		clear cell renal carcinoma								23	14					4.26978e-12	5.01505e-12	1	0	A	53239927	A	A	53239927	3	1	248	1	0	0	0	0	1	0	0	0	8174	739	26	4	3330	4	KDM5C	23	53239927	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	5464147	53239927	102030633	280	45715											
AR	367	broad.mit.edu	37	chrX	66905872	66905872	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaacagaagtacctgtgcGccagcagaaatgattgcact	14	7	11	9	1	0	3	0	1	0	2	0	4	0	4	2	1	5	3	2	1	4	2	rs137852569		TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:66905872G>T	uc004dwu.1	+	3	2904	c.1789G>T	c.(1789-1791)GCC>TCC	p.A597S	AR_uc011mpd.1_Missense_Mutation_p.A597S|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.A597S|AR_uc004dwv.1_Missense_Mutation_p.A65S	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	596	NR C4-type.|Interaction with HIPK3 (By similarity).|Nuclear receptor.		A -> T (in AIS; abolishes dimerization).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GTACCTGTGCGCCAGCAGAAA	0.413									Androgen_Insensitivity_Syndrome				28	17					2.85442e-18	3.54606e-18	1	0	T	66905872	T	T	66905872	3	4	248	1	0	0	0	0	1	0	0	0	836	1087	38	3	1823	3	AR	23	66905872	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	13665945	66905872	88364688	281	45716											
CSTF2	1478	broad.mit.edu	37	chrX	100087825	100087825	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaggggagggccattaccCgagcccagacctctaatggc	9	6	13	13	1	1	2	0	1	1	1	1	4	1	3	4	4	2	0	4	4	2	2			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:100087825C>T	uc004egh.2	+	10	1192	c.1134C>T	c.(1132-1134)CCC>CCT	p.P378P	CSTF2_uc010nnd.2_Silent_p.P398P|CSTF2_uc004egi.2_Silent_p.P361P	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	378	Gly/Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						GGCCATTACCCGAGCCCAGAC	0.582													13	5					0	0	0	0	T	100087825	T	T	100087825	2	4	248	1	0	0	0	0	0	0	0	1	4001	639	23	1		1	CSTF2	23	100087825	Silent	SNP	C	TCGA-CV-7409-01A-31D-2229-08	33181953	100087825	55182735	282	45717											
BHLHB9	80823	broad.mit.edu	37	chrX	102004119	102004119	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggcagtgtctaagaacaagGttgttgctgagacgaaggaa	14	8	14	5	1	1	2	0	1	1	2	1	5	1	3	0	3	2	4	0	3	5	3			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:102004119G>A	uc010nog.2	+	4	767	c.196G>A	c.(196-198)GTT>ATT	p.V66I	BHLHB9_uc011mrq.1_Missense_Mutation_p.V66I|BHLHB9_uc011mrr.1_Missense_Mutation_p.V66I|BHLHB9_uc011mrs.1_Missense_Mutation_p.V66I|BHLHB9_uc011mrt.1_Missense_Mutation_p.V66I|BHLHB9_uc004ejo.2_Missense_Mutation_p.V66I|BHLHB9_uc011mru.1_Missense_Mutation_p.V66I|BHLHB9_uc011mrv.1_Missense_Mutation_p.V66I	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	66						cytoplasm|nucleus	binding			ovary(2)	2						TAAGAACAAGGTTGTTGCTGA	0.517													44	24					0	0	0	0	A	102004119	A	A	102004119	3	1	248	1	0	0	0	0	1	0	0	0	1423	1261	44	4	198	4	BHLHB9	23	102004119	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	1916294	102004119	53266441	283	45718											
PLS3	5358	broad.mit.edu	37	chrX	114856588	114856588	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caacggattcatttgtgactAtgaacttcatgagctcttca	11	14	7	9	1	4	3	3	3	1	0	4	4	4	4	0	1	3	1	0	1	3	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:114856588A>G	uc004eqd.2	+	3	494	c.104A>G	c.(103-105)TAT>TGT	p.Y35C	PLS3_uc010nqf.2_RNA|PLS3_uc010nqg.2_Missense_Mutation_p.Y35C|PLS3_uc011mtf.1_Missense_Mutation_p.Y13C|PLS3_uc004eqe.2_Missense_Mutation_p.Y35C|PLS3_uc011mtg.1_Missense_Mutation_p.Y35C|PLS3_uc011mth.1_5'UTR	NM_005032	NP_005023	P13797	PLST_HUMAN	plastin 3	35	1 (By similarity).|EF-hand 1.					cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2						ATTTGTGACTATGAACTTCAT	0.353													12	30					0	0	0	0	G	114856588	G	G	114856588	3	3	248	1	0	0	0	0	1	0	0	0	12163	449	16	5	110	5	PLS3	23	114856588	Missense_Mutation	SNP	A	TCGA-CV-7409-01A-31D-2229-08	12852469	114856588	40413972	284	45719											
C1GALT1C1	29071	broad.mit.edu	37	chrX	119760791	119760798	+	Frame_Shift_Del	DEL	GGGTTTTA	-	-																															gcccaaagactcacatctttGggttttacaaggataataca																								rs56255076		TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:119760791_119760798delGGGTTTTA	uc004esy.2	-	3	571_578	c.224_231delTAAAACCC	c.(223-231)GTAAAACCCfs	p.V75fs	C1GALT1C1_uc004esz.2_Frame_Shift_Del_p.V75fs	NM_152692	NP_689905	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	75_77	Lumenal (Potential).					integral to membrane					0						TCACATCTTTGGGTTTTACAAGGATAAT	0.399													---	---	---								-	119760798	-	-	119760791	7	5	248	1	0	1	0	1	0	0	0	0	1962	1335	47	0	729	0	C1GALT1C1	23	119760791	Frame_Shift_Del	DEL	GGGTTTTA	TCGA-CV-7409-01A-31D-2229-08	4904203	119760791	35509769	285	45720											
VGLL1	51442	broad.mit.edu	37	chrX	135630910	135630910	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggctaggagggcctctgttcGgcctggggagctgtggcatt	4	10	18	9	1	1	0	0	0	1	0	2	2	1	2	2	7	1	4	2	7	1	3	rs140464879	byFrequency	TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:135630910G>T	uc004ezy.2	+	3	547	c.377G>T	c.(376-378)CGG>CTG	p.R126L	MIR934_hsa-mir-934|MI0005756_5'Flank	NM_016267	NP_057351	Q99990	VGLL1_HUMAN	vestigial like 1	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity				0	Acute lymphoblastic leukemia(192;0.000127)					GCCTCTGTTCGGCCTGGGGAG	0.622													173	122					2.09492e-81	3.22218e-81	1	0	T	135630910	T	T	135630910	3	4	248	1	0	0	0	0	1	0	0	0	17226	1116	39	3	383	3	VGLL1	23	135630910	Missense_Mutation	SNP	G	TCGA-CV-7409-01A-31D-2229-08	15870119	135630910	19639650	286	45721											
CD40LG	959	broad.mit.edu	37	chrX	135741519	135741519	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttgtcaatgtgactgatcCaagccaagtgagccatggca	11	10	11	9	0	1	3	1	3	0	0	2	3	2	3	3	1	2	2	3	1	3	1			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:135741519C>A	uc004faa.2	+	5	803	c.731C>A	c.(730-732)CCA>CAA	p.P244Q	CD40LG_uc010nsd.2_Missense_Mutation_p.P223Q	NM_000074	NP_000065	P29965	CD40L_HUMAN	CD40 ligand	244	Extracellular (Potential).				anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	GTGACTGATCCAAGCCAAGTG	0.522									Immune_Deficiency_with_Hyper-IgM				85	46					1.76421e-39	2.53262e-39	1	0	A	135741519	A	A	135741519	3	1	248	1	0	0	0	0	1	0	0	0	3031	594	21	4	749	4	CD40LG	23	135741519	Missense_Mutation	SNP	C	TCGA-CV-7409-01A-31D-2229-08	110609	135741519	19529041	287	45722											
RAB39B	116442	broad.mit.edu	37	chrX	154490409	154490409	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagggctgaacgtgtactttGgtctcttctaaccactcatg	8	14	9	10	1	3	1	1	1	2	0	4	1	3	1	1	2	3	2	1	2	4	5			TCGA-CV-7409-01A-31D-2229-08	TCGA-CV-7409-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	47fa56f1-0802-403a-a644-913f1a0fdeca	da9648a0-7446-4481-b8ab-ca9cc795e2dd	g.chrX:154490409G>T	uc004fne.2	-	2	600	c.321C>A	c.(319-321)ACC>ACA	p.T107T		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	107					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGTGTACTTTGGTCTCTTCTA	0.493													133	67					5.241e-64	7.98512e-64	1	0	T	154490409	T	T	154490409	2	4	248	1	0	0	0	0	0	0	0	1	12995	1335	47	4		4	RAB39B	23	154490409	Silent	SNP	G	TCGA-CV-7409-01A-31D-2229-08	18748890	154490409	780151	288	45723											
SPEN	23013	broad.mit.edu	37	chr1	16257698	16257698	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatcagccccatcagcactaGagaagaccactggtgacaaa	16	5	8	12	0	2	3	2	1	0	2	2	4	2	3	3	1	2	1	3	1	4	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr1:16257698G>C	uc001axk.1	+	11	5167	c.4963G>C	c.(4963-4965)GAG>CAG	p.E1655Q	SPEN_uc010obp.1_Missense_Mutation_p.E1614Q	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1655					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ATCAGCACTAGAGAAGACCAC	0.493													9	146					0	0	0	0	C	16257698	C	C	16257698	3	2	249	1	0	0	0	0	1	0	0	0	15104	943	33	2	5005	2	SPEN	1	16257698	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08		16257698	232992923	1	45724											
PNPT1	87178	broad.mit.edu	37	chr2	55894995	55894995	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caacaaaaaagggtatgtttAccttttgtattcattcaaaa	16	14	5	6	0	2	0	2	0	0	0	2	0	2	0	1	1	2	3	1	1	9	8			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr2:55894995A>G	uc002rzf.2	-	12	1126	c.1073_splice	c.e12+1	p.R358_splice	PNPT1_uc002rzg.2_Splice_Site	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1						mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGGTATGTTTACCTTTTGTAT	0.308													2	11					0	0	0	0	G	55894995	G	G	55894995	5	3	249	1	0	0	0	0	0	0	1	0	12228	405	14	5	1344	5	PNPT1	2	55894995	Splice_Site	SNP	A	TCGA-CV-7410-01A-21D-2078-08		55894995	187304378	2	45725											
TTN	7273	broad.mit.edu	37	chr2	179635016	179635016	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggcattttccaaggctgtCacatcctttggctttttaat	7	17	8	9	0	1	0	1	0	0	0	3	0	3	0	2	3	0	3	2	3	2	6			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr2:179635016C>G	uc010zfg.1	-	36	8636	c.8412G>C	c.(8410-8412)GTG>GTC	p.V2804V	TTN_uc010zfh.1_Silent_p.V2758V|TTN_uc010zfi.1_Silent_p.V2758V|TTN_uc010zfj.1_Silent_p.V2758V|TTN_uc002unb.2_Silent_p.V2804V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2804							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAAGGCTGTCACATCCTTTG	0.408													6	69					0	0	0	0	G	179635016	G	G	179635016	2	3	249	1	0	0	0	0	0	0	0	1	16803	813	29	2		2	TTN	2	179635016	Silent	SNP	C	TCGA-CV-7410-01A-21D-2078-08	123740021	179635016	63564357	3	45726											
SPP2	6694	broad.mit.edu	37	chr2	234975872	234975872	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattactgtgttacaggtctCatttcagacgagtccataag	11	14	8	8	1	2	1	2	0	1	1	4	2	3	1	1	1	2	1	1	1	4	5			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr2:234975872C>T	uc002vvk.1	+	6	589	c.504C>T	c.(502-504)CTC>CTT	p.L168L	SPP2_uc010fyl.1_Silent_p.L88L	NM_006944	NP_008875	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa precursor	168					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity				0		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		TTACAGGTCTCATTTCAGACG	0.393													7	84					0	0	0	0	T	234975872	T	T	234975872	2	4	249	1	0	0	0	0	0	0	0	1	15153	813	29	2		2	SPP2	2	234975872	Silent	SNP	C	TCGA-CV-7410-01A-21D-2078-08	55340856	234975872	8223501	4	45727											
ALS2CL	259173	broad.mit.edu	37	chr3	46730899	46730899	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagaagacctcctccagcCgcagcagagctgcctcctca	9	6	9	17	1	1	3	1	1	0	3	4	4	4	3	6	0	4	3	6	0	1	0			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr3:46730899C>T	uc003cqa.1	-	2	222	c.32G>A	c.(31-33)CGG>CAG	p.R11Q	ALS2CL_uc003cqb.1_Missense_Mutation_p.R11Q|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	11					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CTCCTCCAGCCGCAGCAGAGC	0.622													3	10					0	0	0	0	T	46730899	T	T	46730899	3	4	249	1	0	0	0	0	1	0	0	0	551	652	23	1	2929	1	ALS2CL	3	46730899	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08		46730899	151291531	5	45728											
RHOA	387	broad.mit.edu	37	chr3	49412905	49412905	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatctgccacatagttctCaaacactgtgggcacataca	13	10	7	11	0	2	0	1	0	2	0	3	1	2	0	1	1	3	2	1	1	4	4			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr3:49412905C>G	uc003cwu.2	-	2	394	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	40	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATAGTTCTCAAACACTGTG	0.438													11	78					0	0	0	0	G	49412905	G	G	49412905	3	3	249	1	0	0	0	0	1	0	0	0	13396	835	29	2	479	2	RHOA	3	49412905	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	2682006	49412905	148609525	6	45729											
MCM2	4171	broad.mit.edu	37	chr3	127335797	127335797	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcagtttctcaagtatattGagaaagtgtccagccgagcc	11	10	10	10	2	1	1	1	1	1	1	3	3	2	1	3	0	2	3	3	0	4	4			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr3:127335797G>A	uc003ejp.2	+	10	1666	c.1609G>A	c.(1609-1611)GAG>AAG	p.E537K	MCM2_uc011bkm.1_Missense_Mutation_p.E407K|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Missense_Mutation_p.E490K	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	537	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						CAAGTATATTGAGAAAGTGTC	0.597													6	117					0	0	0	0	A	127335797	A	A	127335797	3	1	249	1	0	0	0	0	1	0	0	0	9439	1291	45	2	1647	2	MCM2	3	127335797	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08	77922892	127335797	70686633	7	45730											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			5	21					0	0	0	0	A	178936091	A	A	178936091	3	1	249	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08	51600294	178936091	19086339	8	45731											
SMR3B	10879	broad.mit.edu	37	chr4	71255552	71255552	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggatatttccaccaccccCtcctcaaccctaaggtccac	10	8	5	18	0	1	0	1	0	0	0	4	1	4	1	7	2	1	0	7	2	3	3			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr4:71255552C>A	uc011cas.1	+	3	308	c.227C>A	c.(226-228)CCT>CAT	p.P76H	SMR3B_uc003hfh.2_Missense_Mutation_p.P76H	NM_006685	NP_006676	P02814	SMR3B_HUMAN	submaxillary gland androgen regulated protein 3	76	Poly-Pro.|Pro-rich.					extracellular space				skin(1)	1		all_hematologic(202;0.196)				CCACCACCCCCTCCTCAACCC	0.582													6	89					3.59834e-05	3.76441e-05	1	0	A	71255552	A	A	71255552	3	1	249	1	0	0	0	0	1	0	0	0	14876	681	24	4	233	4	SMR3B	4	71255552	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08		71255552	119898724	9	45732											
CDH10	1008	broad.mit.edu	37	chr5	24487840	24487840	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attaaaccgagggccccattCtcggaggtaatcgtagtttt	10	12	10	9	3	1	0	0	0	1	0	3	2	1	1	3	3	1	3	3	3	4	6			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr5:24487840C>G	uc003jgr.1	-	12	2631	c.2299G>C	c.(2299-2301)GAA>CAA	p.E767Q	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	767	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GGGCCCCATTCTCGGAGGTAA	0.413										HNSCC(23;0.051)			6	118					0	0	0	0	G	24487840	G	G	24487840	3	3	249	1	0	0	0	0	1	0	0	0	3111	922	32	2	71	2	CDH10	5	24487840	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08		24487840	156427420	10	45733											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139909243	139909243	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtccactgtcctcacgagttGctacagatgcctctttcact	7	13	7	14	1	3	1	2	0	1	1	5	2	5	1	3	0	3	2	3	0	1	3			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr5:139909243G>T	uc003lfs.1	+	29	6836	c.6712G>T	c.(6712-6714)GCT>TCT	p.A2238S	ANKHD1_uc003lfr.2_Missense_Mutation_p.A2238S|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.A977S|ANKHD1_uc003lfw.2_Missense_Mutation_p.A876S|ANKHD1_uc010jfl.2_Missense_Mutation_p.A673S|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.A375S	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2238						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCACGAGTTGCTACAGATGC	0.507													8	101					1.12685e-05	1.21628e-05	1	0	T	139909243	T	T	139909243	3	4	249	1	0	0	0	0	1	0	0	0	629	1319	46	4	6826	4	ANKHD1-EIF4EBP3	5	139909243	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08	115421403	139909243	41006017	11	45734											
NDST1	3340	broad.mit.edu	37	chr5	149900959	149900959	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagcgaggcctggagccctCggcggatgcccccgagcctg	6	4	16	15	4	0	0	0	0	0	0	1	5	0	2	5	4	4	0	5	4	1	0			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr5:149900959C>T	uc003lsk.3	+	2	645	c.143C>T	c.(142-144)TCG>TTG	p.S48L	NDST1_uc011dcj.1_Missense_Mutation_p.S48L|NDST1_uc003lsl.2_Missense_Mutation_p.S48L	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	48	Heparan sulfate N-deacetylase 1.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGGAGCCCTCGGCGGATGCC	0.652													7	75					0	0	0	0	T	149900959	T	T	149900959	3	4	249	1	0	0	0	0	1	0	0	0	10309	893	31	1	145	1	NDST1	5	149900959	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	9991716	149900959	31014301	12	45735											
BAT2	7916	broad.mit.edu	37	chr6	31598918	31598918	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtctgtctcttcaggaGcgagactcctccagtacctc	6	13	8	14	1	4	1	1	0	3	1	8	3	6	2	3	1	2	1	3	1	1	3			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr6:31598918G>A	uc003nvb.3	+	16	2717	c.2468G>A	c.(2467-2469)AGC>AAC	p.S823N	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.S823N	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	823	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						CTCTTCAGGAGCGAGACTCCT	0.488													9	91					0	0	0	0	A	31598918	A	A	31598918	3	1	249	1	0	0	0	0	1	0	0	0	1321	971	34	4	2526	4	BAT2	6	31598918	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08		31598918	139516149	13	45736											
BRPF3	27154	broad.mit.edu	37	chr6	36175192	36175192	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctgctgattgagctgattCggaagagagagaagctcaaa	13	8	14	6	1	1	5	1	3	0	2	2	8	1	6	0	2	3	4	0	2	3	2			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr6:36175192C>T	uc003olv.3	+	4	1932	c.1708C>T	c.(1708-1710)CGG>TGG	p.R570W	BRPF3_uc010jwb.2_Missense_Mutation_p.R570W|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Missense_Mutation_p.R570W	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	570					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						TGAGCTGATTCGGAAGAGAGA	0.547													4	29					0	0	0	0	T	36175192	T	T	36175192	3	4	249	1	0	0	0	0	1	0	0	0	1526	875	31	1	1718	1	BRPF3	6	36175192	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	4576274	36175192	134939875	14	45737											
COL19A1	1310	broad.mit.edu	37	chr6	70637839	70637839	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttcctgaggagtactcagTagctgccatgtttcgagtac	8	12	10	11	1	1	1	1	1	0	0	3	3	2	2	3	1	4	5	3	1	3	5			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr6:70637839T>C	uc003pfc.1	+	5	422	c.305T>C	c.(304-306)GTA>GCA	p.V102A	COL19A1_uc010kam.1_5'UTR	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	102	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GAGTACTCAGTAGCTGCCATG	0.418													8	85					0	0	0	0	C	70637839	C	C	70637839	3	2	249	1	0	0	0	0	1	0	0	0	3691	1638	57	5	319	5	COL19A1	6	70637839	Missense_Mutation	SNP	T	TCGA-CV-7410-01A-21D-2078-08	34462647	70637839	100477228	15	45738											
EPB41L2	2037	broad.mit.edu	37	chr6	131191239	131191239	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctctgcccgcttcttctcctCcactatattcagagtctcat	6	15	4	16	1	5	1	2	0	4	1	8	1	6	1	3	0	1	1	3	0	2	5			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr6:131191239C>G	uc003qch.2	-	15	2253	c.2071G>C	c.(2071-2073)GAG>CAG	p.E691Q	EPB41L2_uc003qce.1_Missense_Mutation_p.E69Q|EPB41L2_uc003qcf.1_Intron|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Missense_Mutation_p.E621Q|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Missense_Mutation_p.E621Q|EPB41L2_uc003qcd.1_5'Flank|EPB41L2_uc003qcj.1_Missense_Mutation_p.E88Q	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	691					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TTCTTCTCCTCCACTATATTC	0.393													6	45					0	0	0	0	G	131191239	G	G	131191239	3	3	249	1	0	0	0	0	1	0	0	0	5177	864	30	2	966	2	EPB41L2	6	131191239	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	60553400	131191239	39923828	16	45739											
TAGAP	117289	broad.mit.edu	37	chr6	159457885	159457885	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agtgtttggtttgtcacccgGctctcgaggcactcctggga	5	12	13	11	2	2	0	1	0	1	0	4	2	3	1	2	4	0	4	2	4	0	2			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr6:159457885G>A	uc003qrz.2	-	10	1502	c.1170C>T	c.(1168-1170)AGC>AGT	p.S390S	TAGAP_uc011eft.1_Silent_p.S327S|TAGAP_uc003qsa.2_Silent_p.S212S	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	390					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TTGTCACCCGGCTCTCGAGGC	0.582													4	43					0	0	0	0	A	159457885	A	A	159457885	2	1	249	1	0	0	0	0	0	0	0	1	15603	1194	42	4		4	TAGAP	6	159457885	Silent	SNP	G	TCGA-CV-7410-01A-21D-2078-08	28266646	159457885	11657182	17	45740											
SDK1	221935	broad.mit.edu	37	chr7	3998591	3998591	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattttactgctgagcccgaGagtcggatttcagctgaagt	9	13	11	8	2	1	3	1	2	0	1	2	5	1	4	1	1	4	2	1	1	3	4			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:3998591G>C	uc003smx.2	+	8	1318	c.1179G>C	c.(1177-1179)GAG>GAC	p.E393D		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	393	Ig-like C2-type 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CTGAGCCCGAGAGTCGGATTT	0.458													7	101					0	0	0	0	C	3998591	C	C	3998591	3	2	249	1	0	0	0	0	1	0	0	0	14033	933	33	2	1209	2	SDK1	7	3998591	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08		3998591	155140072	18	45741											
CCDC129	223075	broad.mit.edu	37	chr7	31683457	31683457	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaggcaaagccctggccctGaaccctcagtctgtaggcac	10	6	11	14	0	2	2	1	1	1	1	2	2	2	2	3	3	2	3	3	3	3	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:31683457G>A	uc003tcj.1	+	11	3466	c.2473G>A	c.(2473-2475)GAA>AAA	p.E825K	CCDC129_uc011kad.1_Missense_Mutation_p.E835K|CCDC129_uc003tci.1_Missense_Mutation_p.E676K|CCDC129_uc011kae.1_Missense_Mutation_p.E851K|CCDC129_uc003tck.1_Missense_Mutation_p.E733K	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	825	Cys-rich.										0						CCCTGGCCCTGAACCCTCAGT	0.567													4	54					0	0	0	0	A	31683457	A	A	31683457	3	1	249	1	0	0	0	0	1	0	0	0	2776	1291	45	2	2511	2	CCDC129	7	31683457	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08	27684866	31683457	127455206	19	45742											
DDC	1644	broad.mit.edu	37	chr7	50611665	50611665	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcagcggcagggatcagcGgccgcaggtacccgggctcc	6	3	18	14	4	1	0	1	0	0	0	2	1	2	1	3	6	3	5	3	6	1	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:50611665G>A	uc003tpf.3	-	2	205	c.119C>T	c.(118-120)CCG>CTG	p.P40L	DDC_uc010kza.2_Missense_Mutation_p.P40L|DDC_uc003tpg.3_Missense_Mutation_p.P40L	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	40					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	AGGGATCAGCGGCCGCAGGTA	0.572													12	164					0	0	0	0	A	50611665	A	A	50611665	3	1	249	1	0	0	0	0	1	0	0	0	4342	1116	39	1	1375	1	DDC	7	50611665	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08	18928208	50611665	108526998	20	45743											
ZNF107	51427	broad.mit.edu	37	chr7	64167909	64167909	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaaaatttattctggagaGaaaccatacaaatgtgaaga	19	9	9	4	0	1	3	0	1	1	2	1	6	1	5	1	2	2	0	1	2	7	4			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:64167909G>C	uc003ttd.2	+	7	2013	c.1227G>C	c.(1225-1227)GAG>GAC	p.E409D	ZNF107_uc003tte.2_Missense_Mutation_p.E409D	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				ATTCTGGAGAGAAACCATACA	0.338													5	30					0	0	0	0	C	64167909	C	C	64167909	3	2	249	1	0	0	0	0	1	0	0	0	17782	933	33	2	1233	2	ZNF107	7	64167909	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08	13556244	64167909	94970754	21	45744											
SEMA3E	9723	broad.mit.edu	37	chr7	82997162	82997162	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaggcatcctgtgatgccTgtcctcctcatcgtccttgt	6	13	8	14	1	1	1	1	1	0	0	6	1	5	1	5	1	1	1	5	1	1	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:82997162T>A	uc003uhy.1	-	17	2534	c.2068A>T	c.(2068-2070)AGG>TGG	p.R690W		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	690					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				CTGTGATGCCTGTCCTCCTCA	0.478													6	73					0	0	0	0	A	82997162	A	A	82997162	3	1	249	1	0	0	0	0	1	0	0	0	14093	1579	55	5	263	5	SEMA3E	7	82997162	Missense_Mutation	SNP	T	TCGA-CV-7410-01A-21D-2078-08	18829253	82997162	76141501	22	45745											
ZNF394	84124	broad.mit.edu	37	chr7	99097343	99097343	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgctctctgggcagtgctctCgcacccaggcttgaagctcc	5	9	11	16	2	2	1	0	1	2	0	5	1	3	1	2	2	2	6	2	2	1	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:99097343C>T	uc003uqs.2	-	1	535	c.374G>A	c.(373-375)CGA>CAA	p.R125Q	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Missense_Mutation_p.R125Q	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	125	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GCAGTGCTCTCGCACCCAGGC	0.652													10	105					0	0	0	0	T	99097343	T	T	99097343	3	4	249	1	0	0	0	0	1	0	0	0	17947	884	31	1	1323	1	ZNF394	7	99097343	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	16100181	99097343	60041320	23	45746											
TAS2R60	338398	broad.mit.edu	37	chr7	143140947	143140947	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgtcttcttctggctaaaGcacaagttgtctgggtggct	6	14	11	10	0	4	0	0	0	4	0	4	0	4	0	1	3	1	4	1	3	3	4			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:143140947G>A	uc011ktg.1	+	1	402	c.402G>A	c.(400-402)AAG>AAA	p.K134K	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	134	Helical; Name=4; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					TCTGGCTAAAGCACAAGTTGT	0.478													10	140					0	0	0	0	A	143140947	A	A	143140947	2	1	249	1	0	0	0	0	0	0	0	1	15651	962	34	4		4	TAS2R60	7	143140947	Silent	SNP	G	TCGA-CV-7410-01A-21D-2078-08	44043604	143140947	15997716	24	45747											
RBM12B	389677	broad.mit.edu	37	chr8	94746334	94746335	+	Frame_Shift_Ins	INS	-	TG	TG																															ggcgggcgcctgaaatgctcINStgggggtggccgcctgaagt																										TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr8:94746334_94746335insTG	uc003yfz.2	-	3	2497_2498	c.2304_2305insCA	c.(2302-2307)CCAGAGfs	p.P768fs		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	768_769							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CTGAAATGCTCTGGGGGTGGCC	0.673													---	---	---								TG	94746335	TG	TG	94746334	7	5	249	1	0	1	1	0	0	0	0	0	13179	922	32	0	704	0	RBM12B	8	94746334	Frame_Shift_Ins	INS	-	TCGA-CV-7410-01A-21D-2078-08		94746334	51617688	25	45748											
RAD54B	25788	broad.mit.edu	37	chr8	95419850	95419850	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgccactgctgaagtcatCtggagagattacacccatga	11	9	9	12	0	2	3	1	2	1	1	2	5	2	4	3	1	3	1	3	1	2	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr8:95419850C>T	uc003ygk.2	-	5	696	c.598G>A	c.(598-600)GAT>AAT	p.D200N	RAD54B_uc010may.1_Missense_Mutation_p.D7N|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			CTGAAGTCATCTGGAGAGATT	0.418								Direct_reversal_of_damage|Homologous_recombination					4	53					0	0	0	0	T	95419850	T	T	95419850	3	4	249	1	0	0	0	0	1	0	0	0	13057	913	32	2	2178	2	RAD54B	8	95419850	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	673516	95419850	50944172	26	45749											
SHC3	53358	broad.mit.edu	37	chr9	91667004	91667004	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtaaatattgcttaaaccGgagctcaaaggcttgtccga	12	11	9	9	2	1	0	1	0	0	0	2	2	2	1	2	2	3	4	2	2	6	5	rs150757692		TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:91667004G>A	uc004aqg.2	-	7	1217	c.910C>T	c.(910-912)CGG>TGG	p.R304W		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	304	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						TGCTTAAACCGGAGCTCAAAG	0.493													4	47					0	0	0	0	A	91667004	A	A	91667004	3	1	249	1	0	0	0	0	1	0	0	0	14337	1115	39	1	898	1	SHC3	9	91667004	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08		91667004	49546427	27	45750											
ZNF483	158399	broad.mit.edu	37	chr9	114304152	114304152	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttggacataatttcaaaGaaacttcagacttaattaaa	17	13	4	7	0	2	2	2	0	0	2	2	3	2	3	1	1	1	0	1	1	6	6			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:114304152G>C	uc004bff.2	+	6	1161	c.937G>C	c.(937-939)GAA>CAA	p.E313Q	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	313					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						TAATTTCAAAGAAACTTCAGA	0.378													7	123					0	0	0	0	C	114304152	C	C	114304152	3	2	249	1	0	0	0	0	1	0	0	0	18003	943	33	2	955	2	ZNF483	9	114304152	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08	22637148	114304152	26909279	28	45751											
COL27A1	85301	broad.mit.edu	37	chr9	117014887	117014887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcacagggtgatcgtggcatGatgggacccccaggcgtgcc	7	7	15	12	2	1	2	1	2	0	0	2	3	1	3	3	4	1	1	3	4	0	0			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:117014887G>A	uc011lxl.1	+	26	3048	c.3048G>A	c.(3046-3048)ATG>ATA	p.M1016I	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1016	Pro-rich.|Collagen-like 7.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						ATCGTGGCATGATGGGACCCC	0.612													9	98					0	0	0	0	A	117014887	A	A	117014887	3	1	249	1	0	0	0	0	1	0	0	0	3700	1290	45	2	3150	2	COL27A1	9	117014887	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08	2710735	117014887	24198544	29	45752											
ZBTB34	403341	broad.mit.edu	37	chr9	129642755	129642755	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccccgggtatgagagcagTccccgggagaggagtgcgag	10	4	17	10	3	0	2	0	1	0	2	1	6	1	3	4	3	3	2	4	3	2	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:129642755T>C	uc004bqm.3	+	2	1162	c.1065T>C	c.(1063-1065)AGT>AGC	p.S355S		NM_001099270	NP_001092740	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATGAGAGCAGTCCCCGGGAGA	0.542													3	30					0	0	0	0	C	129642755	C	C	129642755	2	2	249	1	0	0	0	0	0	0	0	1	17604	1664	58	5		5	ZBTB34	9	129642755	Silent	SNP	T	TCGA-CV-7410-01A-21D-2078-08	12627868	129642755	11570676	30	45753											
NOTCH1	4851	broad.mit.edu	37	chr9	139405640	139405640	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagacacaggagaagctctCatagtcctcggattgcctgc	10	8	11	12	1	1	2	1	0	1	2	4	4	2	3	2	2	3	2	2	2	2	2			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:139405640C>G	uc004chz.2	-	16	2551	c.2551G>C	c.(2551-2553)GAG>CAG	p.E851Q	NOTCH1_uc004cia.1_Missense_Mutation_p.E81Q	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	851	Extracellular (Potential).|EGF-like 22.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GAGAAGCTCTCATAGTCCTCG	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			5	45					0	0	0	0	G	139405640	G	G	139405640	3	3	249	1	0	0	0	0	1	0	0	0	10601	835	29	2	5192	2	NOTCH1	9	139405640	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	9762885	139405640	1807791	31	45754											
NOTCH1	4851	broad.mit.edu	37	chr9	139409769	139409769	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccggctcacaggcacactCgtagccatcgatcttgtcca	8	8	9	16	3	2	0	1	0	1	0	5	1	3	0	3	2	1	3	3	2	1	2			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:139409769C>T	uc004chz.2	-	12	1987	c.1987G>A	c.(1987-1989)GAG>AAG	p.E663K	NOTCH1_uc004cia.1_5'Flank	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	663	Extracellular (Potential).|EGF-like 17; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CAGGCACACTCGTAGCCATCG	0.637			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			5	46					0	0	0	0	T	139409769	T	T	139409769	3	4	249	1	0	0	0	0	1	0	0	0	10601	893	31	1	5772	1	NOTCH1	9	139409769	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	4129	139409769	1803662	32	45755											
BEND7	222389	broad.mit.edu	37	chr10	13481367	13481367	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtaaggttgttcaggagcacGagatgctgctcctcccaggg	8	9	14	10	1	1	1	1	0	0	1	3	3	3	2	2	3	3	6	2	3	1	3			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr10:13481367G>C	uc001imm.2	-	9	1509	c.1212C>G	c.(1210-1212)CTC>CTG	p.L404L	BEND7_uc001iml.2_RNA	NM_152751	NP_689964	Q8N7W2	BEND7_HUMAN	BEN domain containing 7 isoform 1	455							protein binding			ovary(1)|breast(1)	2						TCAGGAGCACGAGATGCTGCT	0.493													4	38					0	0	0	0	C	13481367	C	C	13481367	2	2	249	1	0	0	0	0	0	0	0	1	1405	1045	37	3		3	BEND7	10	13481367	Silent	SNP	G	TCGA-CV-7410-01A-21D-2078-08		13481367	122053380	33	45756											
OR5D14	219436	broad.mit.edu	37	chr11	55563470	55563470	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaggctctgtgccctgctgGtggctgggtcatatctctgg	4	12	15	10	0	3	1	1	0	2	1	4	1	3	1	1	5	2	3	1	5	1	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr11:55563470G>T	uc010rim.1	+	1	439	c.439G>T	c.(439-441)GTG>TTG	p.V147L		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TGCCCTGCTGGTGGCTGGGTC	0.507													6	65					3.59834e-05	3.76441e-05	1	0	T	55563470	T	T	55563470	3	4	249	1	0	0	0	0	1	0	0	0	11209	1261	44	4	441	4	OR5D14	11	55563470	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08		55563470	79443046	34	45757											
OR5D18	219438	broad.mit.edu	37	chr11	55587255	55587255	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgggttgattgtgatcatCaaaatcaaccccaaactgca	14	11	7	9	0	3	2	3	2	0	0	3	2	3	2	2	1	3	2	2	1	4	3			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr11:55587255C>G	uc010rin.1	+	1	150	c.150C>G	c.(148-150)ATC>ATG	p.I50M		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TTGTGATCATCAAAATCAACC	0.453													8	106					0	0	0	0	G	55587255	G	G	55587255	3	3	249	1	0	0	0	0	1	0	0	0	11211	816	29	2	152	2	OR5D18	11	55587255	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	23785	55587255	79419261	35	45758											
IGHMBP2	3508	broad.mit.edu	37	chr11	68703725	68703725	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaagttggttttcttgctGaggaccggaggatcaacgtg	8	12	15	6	2	2	2	1	2	1	0	2	5	2	5	1	4	2	3	1	4	2	4			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr11:68703725G>A	uc001ook.1	+	13	1879	c.1777G>A	c.(1777-1779)GAG>AAG	p.E593K	IGHMBP2_uc001ool.1_Missense_Mutation_p.E217K|IGHMBP2_uc001oom.1_Missense_Mutation_p.E171K	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	593					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTTTCTTGCTGAGGACCGGAG	0.532													14	99					0	0	0	0	A	68703725	A	A	68703725	3	1	249	1	0	0	0	0	1	0	0	0	7630	1291	45	2	1827	2	IGHMBP2	11	68703725	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08	13116470	68703725	66302791	36	45759											
GYS2	2998	broad.mit.edu	37	chr12	21728963	21728963	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaagtaccacataaggacttCcttctatcagccatcttcca	13	11	4	13	0	3	0	1	0	2	0	5	1	5	1	4	1	2	1	4	1	4	6			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr12:21728963C>T	uc001rfb.2	-	3	587	c.332G>A	c.(331-333)GGA>GAA	p.G111E		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	111					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						ATAAGGACTTCCTTCTATCAG	0.433													4	54					0	0	0	0	T	21728963	T	T	21728963	3	4	249	1	0	0	0	0	1	0	0	0	6952	855	30	2	1835	2	GYS2	12	21728963	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08		21728963	112122932	37	45760											
LARP4	113251	broad.mit.edu	37	chr12	50869453	50869453	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atggagctcctgagaactccGttgagaaaccacatgagaag	14	7	11	9	1	0	3	0	3	0	3	2	7	2	4	3	1	3	2	3	1	3	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr12:50869453G>T	uc001rwp.1	+	16	2125	c.1981G>T	c.(1981-1983)GTT>TTT	p.V661F	LARP4_uc001rwo.1_Missense_Mutation_p.V667F|LARP4_uc001rwq.1_Missense_Mutation_p.V590F|LARP4_uc001rwr.1_Missense_Mutation_p.V590F|LARP4_uc001rws.1_Missense_Mutation_p.V660F|LARP4_uc009zlr.1_Missense_Mutation_p.V460F|LARP4_uc001rwt.1_Missense_Mutation_p.V252F	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	661							nucleotide binding|RNA binding			ovary(1)	1						TGAGAACTCCGTTGAGAAACC	0.488													8	110					5.18039e-06	5.68172e-06	1	0	T	50869453	T	T	50869453	3	4	249	1	0	0	0	0	1	0	0	0	8670	1145	40	3	2047	3	LARP4	12	50869453	Missense_Mutation	SNP	G	TCGA-CV-7410-01A-21D-2078-08	29140490	50869453	82982442	38	45761											
MBD6	114785	broad.mit.edu	37	chr12	57919453	57919454	+	Frame_Shift_Ins	INS	-	T	T																															actggggagctgccctcagaINStccagcctggtgccctctga																										TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr12:57919453_57919454insT	uc001soj.1	+	6	926_927	c.702_703insT	c.(700-705)AGATCCfs	p.R234fs	MBD6_uc001sok.1_Frame_Shift_Ins_p.R101fs|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	234_235	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CTGCCCTCAGATCCAGCCTGGT	0.619													---	---	---								T	57919454	T	T	57919453	7	5	249	1	0	1	1	0	0	0	0	0	9401	330	12	0	716	0	MBD6	12	57919453	Frame_Shift_Ins	INS	-	TCGA-CV-7410-01A-21D-2078-08	7050000	57919453	75932442	39	45762											
IRAK3	11213	broad.mit.edu	37	chr12	66641854	66641854	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtaaatatagatccttcttCagaagctccagggcattctt	11	13	8	9	0	3	2	1	0	2	2	5	2	5	2	2	2	1	3	2	2	5	7			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr12:66641854C>G	uc001sth.2	+	12	1796	c.1694C>G	c.(1693-1695)TCA>TGA	p.S565*	IRAK3_uc010ssy.1_Nonsense_Mutation_p.S504*	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	565					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		GATCCTTCTTCAGAAGCTCCA	0.423													5	84					0	0	0	0	G	66641854	G	G	66641854	4	3	249	1	0	0	0	0	0	1	0	0	7863	838	29	2	1740	2	IRAK3	12	66641854	Nonsense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	8722401	66641854	67210041	40	45763											
PCDH9	5101	broad.mit.edu	37	chr13	67801363	67801363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaaatgggacctctctttCaataaaacagatcactttgc	14	12	6	9	0	3	2	2	1	1	1	4	3	3	3	1	1	2	0	1	1	4	3			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr13:67801363C>T	uc001vik.2	-	2	1902	c.1210G>A	c.(1210-1212)GAA>AAA	p.E404K	PCDH9_uc001vil.2_Missense_Mutation_p.E404K|PCDH9_uc010thl.1_Missense_Mutation_p.E404K|PCDH9_uc001vin.3_Missense_Mutation_p.E404K	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	404	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ACCTCTCTTTCAATAAAACAG	0.378													5	70					0	0	0	0	T	67801363	T	T	67801363	3	4	249	1	0	0	0	0	1	0	0	0	11572	835	29	2	2519	2	PCDH9	13	67801363	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08		67801363	47368515	41	45764											
MESDC1	59274	broad.mit.edu	37	chr15	81295191	81295191	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgtcgcgcaacctcaagttCctgacggacgcgtgcgccct	6	8	11	16	6	1	1	1	1	0	0	3	2	2	2	3	1	2	2	3	1	2	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr15:81295191C>T	uc002bfz.2	+	1	1897	c.579C>T	c.(577-579)TTC>TTT	p.F193F		NM_022566	NP_072088	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	193											0						ACCTCAAGTTCCTGACGGACG	0.682													3	10					0	0	0	0	T	81295191	T	T	81295191	2	4	249	1	0	0	0	0	0	0	0	1	9533	854	30	2		2	MESDC1	15	81295191	Silent	SNP	C	TCGA-CV-7410-01A-21D-2078-08		81295191	21236201	42	45765											
FSD2	123722	broad.mit.edu	37	chr15	83447594	83447594	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcttcaaactcaggctgTgcagagatttccacgtctgt	8	13	10	10	1	4	1	2	0	2	1	5	2	5	1	1	2	2	2	1	2	1	2			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr15:83447594T>C	uc002bjd.2	-	6	1202	c.1035A>G	c.(1033-1035)GCA>GCG	p.A345A	FSD2_uc010uol.1_Silent_p.A345A|FSD2_uc010uom.1_Silent_p.A345A	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	345										central_nervous_system(1)	1						ACTCAGGCTGTGCAGAGATTT	0.468													3	31					0	0	0	0	C	83447594	C	C	83447594	2	2	249	1	0	0	0	0	0	0	0	1	6105	1683	59	5		5	FSD2	15	83447594	Silent	SNP	T	TCGA-CV-7410-01A-21D-2078-08	2152403	83447594	19083798	43	45766											
ACAN	176	broad.mit.edu	37	chr15	89395139	89395139	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggtgtggctgctgtccccgTagaagaggagacaactgctg	8	9	15	9	1	0	3	0	0	0	3	1	4	1	3	2	3	3	4	2	3	3	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr15:89395139T>C	uc010upo.1	+	11	2515	c.2141T>C	c.(2140-2142)GTA>GCA	p.V714A	ACAN_uc010upp.1_Missense_Mutation_p.V714A|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	714					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GCTGTCCCCGTAGAAGAGGAG	0.567													2	10					0	0	0	0	C	89395139	C	C	89395139	3	2	249	1	0	0	0	0	1	0	0	0	117	1638	57	5	2179	5	ACAN	15	89395139	Missense_Mutation	SNP	T	TCGA-CV-7410-01A-21D-2078-08	5947545	89395139	13136253	44	45767											
XYLT1	64131	broad.mit.edu	37	chr16	17211720	17211720	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatccacccaaatgacggtCacggtcacattaggtccctt	10	9	9	13	2	2	1	2	1	0	0	4	2	4	2	3	4	0	0	3	4	2	2			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr16:17211720C>T	uc002dfa.2	-	11	2425	c.2340G>A	c.(2338-2340)GTG>GTA	p.V780V		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	780	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						AAATGACGGTCACGGTCACAT	0.552													4	44					0	0	0	0	T	17211720	T	T	17211720	2	4	249	1	0	0	0	0	0	0	0	1	17531	813	29	2		2	XYLT1	16	17211720	Silent	SNP	C	TCGA-CV-7410-01A-21D-2078-08		17211720	73143033	45	45768											
ATP2C2	9914	broad.mit.edu	37	chr16	84488581	84488581	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggtggatgatgacttctCagccatcatgtaagctgccc	8	11	10	12	0	2	2	2	2	1	0	3	3	2	3	3	2	3	2	3	2	1	2			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr16:84488581C>G	uc002fhx.2	+	21	2227	c.2138C>G	c.(2137-2139)TCA>TGA	p.S713*	ATP2C2_uc010chj.2_Nonsense_Mutation_p.S713*|ATP2C2_uc002fhy.2_Nonsense_Mutation_p.S730*|ATP2C2_uc002fhz.2_Nonsense_Mutation_p.S562*	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	713	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						GATGACTTCTCAGCCATCATG	0.552													4	39					0	0	0	0	G	84488581	G	G	84488581	4	3	249	1	0	0	0	0	0	1	0	0	1146	838	29	2	2220	2	ATP2C2	16	84488581	Nonsense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	67276861	84488581	5866172	46	45769											
FAM18B2	201158	broad.mit.edu	37	chr17	15468766	15468766	+	5'Flank	DEL	A	-	-																															attaccaggaagaaacagtcAaaaaaaaaaaaaaaggccaa																										TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr17:15468766delA	uc002goq.2	-						CDRT4_uc010vvw.1_5'Flank|FAM18B2_uc010vvx.1_5'Flank|FAM18B2_uc010cor.2_5'Flank	NM_145301	NP_660344	Q96ET8	F18B2_HUMAN	hypothetical protein LOC201158 isoform 1							integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0872)|BRCA - Breast invasive adenocarcinoma(8;0.0581)|READ - Rectum adenocarcinoma(1115;0.0967)		AGAAACAGTCAAAAAAAAAAA	0.353													---	---	---								-	15468766	-	-	15468766	6	5	249	0	1	1	0	1	0	0	0	0	5548	145	5	0		0	FAM18B2	17	15468766	5'Flank	DEL	A	TCGA-CV-7410-01A-21D-2078-08		15468766	65726444	47	45770											
ANKRD40	91369	broad.mit.edu	37	chr17	48777098	48777098	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgcagggggtgtggaggggCccccattctgcatctgggct	5	9	17	10	0	2	0	0	0	2	0	2	1	2	1	2	6	2	3	2	6	0	1			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr17:48777098C>T	uc002iso.2	-	3	695	c.440G>A	c.(439-441)GGC>GAC	p.G147D		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	147											0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			TGTGGAGGGGCCCCCATTCTG	0.587													4	61					0	0	0	0	T	48777098	T	T	48777098	3	4	249	1	0	0	0	0	1	0	0	0	669	739	26	4	678	4	ANKRD40	17	48777098	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08	33308332	48777098	32418112	48	45771											
MCF2	4168	broad.mit.edu	37	chrX	138699732	138699732	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtatccgttttgcttttatCtcattaaccaaaatatcaga	12	17	4	8	1	2	1	2	0	1	1	4	1	3	1	2	0	2	3	2	0	6	7			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chrX:138699732C>A	uc004fau.2	-	8	1233	c.939G>T	c.(937-939)GAG>GAT	p.E313D	MCF2_uc004fav.2_Missense_Mutation_p.E313D|MCF2_uc011mwl.1_Missense_Mutation_p.E274D|MCF2_uc010nsh.1_Missense_Mutation_p.E313D|MCF2_uc011mwm.1_Missense_Mutation_p.E274D|MCF2_uc011mwn.1_Missense_Mutation_p.E458D|MCF2_uc004faw.2_Missense_Mutation_p.E373D|MCF2_uc011mwo.1_Missense_Mutation_p.E373D	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	313	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TTGCTTTTATCTCATTAACCA	0.393													6	47					0.00198382	0.00204393	1	0	A	138699732	A	A	138699732	3	1	249	1	0	0	0	0	1	0	0	0	9431	912	32	2	1990	2	MCF2	23	138699732	Missense_Mutation	SNP	C	TCGA-CV-7410-01A-21D-2078-08		138699732	16570828	49	45772											
FAM131C	348487	broad.mit.edu	37	chr1	16385163	16385163	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggcctgaaggctgtcatcCtgtgaggggccgctgggaag	8	7	17	9	1	1	2	1	2	0	0	2	3	2	3	3	5	0	2	3	5	3	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:16385163C>T	uc001axz.3	-	7	802	c.612G>A	c.(610-612)CAG>CAA	p.Q204Q	FAM131C_uc010obz.1_Intron	NM_182623	NP_872429	Q96AQ9	F131C_HUMAN	hypothetical protein LOC348487	204											0		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.32e-08)|COAD - Colon adenocarcinoma(227;5.56e-06)|BRCA - Breast invasive adenocarcinoma(304;9.12e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00656)|READ - Rectum adenocarcinoma(331;0.0649)		GGCTGTCATCCTGTGAGGGGC	0.652													2	4					0	0	0	0	T	16385163	T	T	16385163	2	4	250	1	0	0	0	0	0	0	0	1	5469	680	24	4		4	FAM131C	1	16385163	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08		16385163	232865458	1	45773											
MATN1	4146	broad.mit.edu	37	chr1	31188840	31188840	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgcccaccttctgggcccCgggcctagccccactggaca	7	6	10	18	1	1	0	0	0	1	0	1	1	1	1	7	3	2	0	7	3	2	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:31188840C>T	uc001brz.2	-	5	1157	c.1123G>A	c.(1123-1125)GGG>AGG	p.G375R	uc001bsb.1_5'Flank|MATN1_uc001bsa.1_Missense_Mutation_p.G293R	NM_002379	NP_002370	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein precursor	375	VWFA 2.				protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)	1		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		TTCTGGGCCCCGGGCCTAGCC	0.552													11	73					0	0	0	0	T	31188840	T	T	31188840	3	4	250	1	0	0	0	0	1	0	0	0	9386	652	23	1	383	1	MATN1	1	31188840	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	14803677	31188840	218061781	2	45774											
MRPS15	64960	broad.mit.edu	37	chr1	36929441	36929441	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acatatccgcgcgcggcctgGaggaggagacctacgcagaa	11	4	14	12	5	0	2	0	0	0	2	1	5	1	4	3	4	1	1	3	4	3	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:36929441G>C	uc001cas.2	-	2	305	c.141C>G	c.(139-141)CTC>CTG	p.L47L		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	47				GGGSAKFPFNQWGLQPRSLLLQAARGYVVRKPAQSRLDDDP PPSTLLKDYQNV -> AVGAPSFLSTSGACSLEVSSSRPRA DMSSGNQPSLGWMMTHLLLRCSKTTRMS (in Ref. 2; AAG44697).	translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCGCGGCCTGGAGGAGGAGAC	0.607													6	36					0	0	0	0	C	36929441	C	C	36929441	2	2	250	1	0	0	0	0	0	0	0	1	9878	1161	41	2		2	MRPS15	1	36929441	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	5740601	36929441	212321180	3	45775											
MTF1	4520	broad.mit.edu	37	chr1	38305745	38305745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agacaaaggtgtactctcctCggtgagtcttctggtgggtt	7	13	13	8	1	3	2	0	1	3	1	5	2	3	2	1	4	1	2	1	4	2	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:38305745C>T	uc001cce.1	-	3	635	c.494G>A	c.(493-495)CGA>CAA	p.R165Q	MTF1_uc009vvj.1_5'UTR	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	165						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GTACTCTCCTCGGTGAGTCTT	0.547													11	50					0	0	0	0	T	38305745	T	T	38305745	3	4	250	1	0	0	0	0	1	0	0	0	9975	884	31	1	1803	1	MTF1	1	38305745	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	1376304	38305745	210944876	4	45776											
AKNAD1	254268	broad.mit.edu	37	chr1	109391400	109391400	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cttgtcttgcaaatggtaagGagagtcctgttttattcttt	8	18	9	6	0	2	1	0	0	2	1	3	2	3	1	1	2	1	3	1	2	3	7			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:109391400G>C	uc001dwa.2	-	5	1488	c.1219C>G	c.(1219-1221)CCT>GCT	p.P407A	AKNAD1_uc010ovb.1_Missense_Mutation_p.P114A|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	407	Potential.									ovary(3)	3						AAATGGTAAGGAGAGTCCTGT	0.313													11	77					0	0	0	0	C	109391400	C	C	109391400	3	2	250	1	0	0	0	0	1	0	0	0	464	1174	41	2	1339	2	AKNAD1	1	109391400	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	71085655	109391400	139859221	5	45777											
POGZ	23126	broad.mit.edu	37	chr1	151377602	151377602	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctagcacttcacccagccaGacaagcaccagctgaagcag	13	4	8	16	0	1	2	1	1	0	1	1	2	1	2	4	0	5	4	4	0	3	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:151377602G>C	uc001eyd.1	-	19	4215	c.3909C>G	c.(3907-3909)GTC>GTG	p.V1303V	POGZ_uc001eye.1_Silent_p.V1250V|POGZ_uc010pdb.1_Silent_p.V1294V|POGZ_uc001eyf.1_Silent_p.V1259V|POGZ_uc010pdc.1_Silent_p.V1241V|POGZ_uc009wmv.1_Silent_p.V1208V|POGZ_uc010pdd.1_Silent_p.V794V	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	1303	DDE.				cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CACCCAGCCAGACAAGCACCA	0.517													27	85					0	0	0	0	C	151377602	C	C	151377602	2	2	250	1	0	0	0	0	0	0	0	1	12241	929	33	2		2	POGZ	1	151377602	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	41986202	151377602	97873019	6	45778											
NES	10763	broad.mit.edu	37	chr1	156642028	156642028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttactaattcttgattttccGttcctggaaataaaaatgtc	12	17	5	7	1	1	1	0	1	1	0	4	2	3	2	2	1	1	1	2	1	6	8			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:156642028G>A	uc001fpq.2	-	4	2085	c.1952C>T	c.(1951-1953)ACG>ATG	p.T651M		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	651	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTGATTTTCCGTTCCTGGAAA	0.398													10	38					0	0	0	0	A	156642028	A	A	156642028	3	1	250	1	0	0	0	0	1	0	0	0	10391	1145	40	1	2917	1	NES	1	156642028	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	5264426	156642028	92608593	7	45779											
FCRL3	115352	broad.mit.edu	37	chr1	157665837	157665837	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatcggaacttacttctcacGgtgactcgaatccacgtgct	10	11	8	12	4	1	1	1	1	1	0	5	3	2	2	1	2	3	1	1	2	4	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:157665837G>T	uc001frb.2	-	7	1417	c.1125C>A	c.(1123-1125)ACC>ACA	p.T375T	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.T375T|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.T101T|FCRL3_uc001frc.1_Silent_p.T375T	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	375	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TACTTCTCACGGTGACTCGAA	0.522													6	30					2.0095e-06	2.17466e-06	1	0	T	157665837	T	T	157665837	2	4	250	1	0	0	0	0	0	0	0	1	5828	1103	39	3		3	FCRL3	1	157665837	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	1023809	157665837	91584784	8	45780											
FMO4	2329	broad.mit.edu	37	chr1	171303659	171303659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaaacctctgctgtctttGaagatgggacagtggaagaa	13	9	12	7	0	2	4	0	1	2	3	2	6	2	6	1	2	2	1	1	2	4	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:171303659G>A	uc001gho.2	+	8	1154	c.937G>A	c.(937-939)GAA>AAA	p.E313K		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	313					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGCTGTCTTTGAAGATGGGAC	0.378													11	50					0	0	0	0	A	171303659	A	A	171303659	3	1	250	1	0	0	0	0	1	0	0	0	5989	1291	45	2	959	2	FMO4	1	171303659	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	13637822	171303659	77946962	9	45781											
ASPM	259266	broad.mit.edu	37	chr1	197111547	197111547	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttgttttcttaacagctGatgttttaggctctgaggga	7	19	10	5	0	2	2	0	2	2	0	2	3	2	3	0	2	2	4	0	2	2	7			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:197111547G>A	uc001gtu.2	-	3	2092	c.1835C>T	c.(1834-1836)TCA>TTA	p.S612L	ASPM_uc001gtv.2_Missense_Mutation_p.S612L|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	612					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CTTAACAGCTGATGTTTTAGG	0.368													33	127					0	0	0	0	A	197111547	A	A	197111547	3	1	250	1	0	0	0	0	1	0	0	0	1058	1294	45	2	8702	2	ASPM	1	197111547	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	25807888	197111547	52139074	10	45782											
PLXNA2	5362	broad.mit.edu	37	chr1	208202360	208202360	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgaactgggggttcttaatCacgttcacccagaagcgcag	11	8	11	11	3	3	1	2	0	1	1	3	2	3	1	1	2	2	3	1	2	3	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:208202360C>A	uc001hgz.2	-	30	6011	c.5253G>T	c.(5251-5253)GTG>GTT	p.V1751V	PLXNA2_uc001hgy.2_Silent_p.V21V	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1751	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GGTTCTTAATCACGTTCACCC	0.562													14	34					1.99824e-07	2.20784e-07	1	0	A	208202360	A	A	208202360	2	1	250	1	0	0	0	0	0	0	0	1	12175	813	29	2		2	PLXNA2	1	208202360	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08	11090813	208202360	41048261	11	45783											
RYR2	6262	broad.mit.edu	37	chr1	237780641	237780641	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggtccggcaccggatagaagCcattgtagccttttcagatg	9	10	12	10	2	1	2	1	0	0	2	2	3	2	3	4	3	2	2	4	3	3	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:237780641C>T	uc001hyl.1	+	38	5891	c.5771C>T	c.(5770-5772)GCC>GTC	p.A1924V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1924	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGGATAGAAGCCATTGTAGCC	0.433													6	22					0	0	0	0	T	237780641	T	T	237780641	3	4	250	1	0	0	0	0	1	0	0	0	13834	739	26	4	5921	4	RYR2	1	237780641	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	29578281	237780641	11469980	12	45784											
OR2L8	391190	broad.mit.edu	37	chr1	248112339	248112339	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccacacacccatgtatttCctactgagtcagctctccct	8	12	4	17	0	2	1	1	1	1	0	5	1	4	1	4	0	2	2	4	0	2	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr1:248112339C>T	uc001idt.1	+	1	180	c.180C>T	c.(178-180)TTC>TTT	p.F60F	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CCATGTATTTCCTACTGAGTC	0.413													7	329					0	0	0	0	T	248112339	T	T	248112339	2	4	250	1	0	0	0	0	0	0	0	1	11063	854	30	2		2	OR2L8	1	248112339	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08	10331698	248112339	1138282	13	45785											
CRIM1	51232	broad.mit.edu	37	chr2	36691747	36691747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccactccccgcatagtctctCgtggcgatgggacacctgga	7	8	11	15	3	1	0	0	0	1	0	4	3	2	2	4	3	0	1	4	3	1	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr2:36691747C>T	uc002rpd.2	+	5	979	c.940C>T	c.(940-942)CGT>TGT	p.R314C		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	314	Extracellular (Potential).|Cell attachment site (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				CATAGTCTCTCGTGGCGATGG	0.498													30	109					0	0	0	0	T	36691747	T	T	36691747	3	4	250	1	0	0	0	0	1	0	0	0	3888	884	31	1	958	1	CRIM1	2	36691747	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08		36691747	206507626	14	45786											
LRRTM1	347730	broad.mit.edu	37	chr2	80530211	80530211	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgagctgaccacaatggccAccttgttcctccgcaggcag	8	7	11	15	2	0	1	0	1	0	0	2	2	2	1	5	2	1	4	5	2	1	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr2:80530211A>T	uc002sok.1	-	2	1004	c.734T>A	c.(733-735)GTG>GAG	p.V245E	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	245	LRR 7.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CACAATGGCCACCTTGTTCCT	0.587										HNSCC(69;0.2)			18	58					0	0	0	0	T	80530211	T	T	80530211	3	4	250	1	0	0	0	0	1	0	0	0	9089	159	6	5	838	5	LRRTM1	2	80530211	Missense_Mutation	SNP	A	TCGA-CV-7411-01A-11D-2078-08	43838464	80530211	162669162	15	45787											
CNGA3	1261	broad.mit.edu	37	chr2	99013277	99013277	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agcgatggcagctacttcggGgagatcagcattctgaacat	11	9	12	9	2	2	2	1	1	1	1	3	4	2	2	0	3	5	3	0	3	2	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr2:99013277G>A	uc002syt.2	+	8	2061	c.1644G>A	c.(1642-1644)GGG>GGA	p.G548G	CNGA3_uc002syu.2_Silent_p.G530G|CNGA3_uc010fij.2_Silent_p.G552G	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	548	cGMP.		G -> R (in ACHM2).		signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						GCTACTTCGGGGAGATCAGCA	0.572													28	87					0	0	0	0	A	99013277	A	A	99013277	2	1	250	1	0	0	0	0	0	0	0	1	3613	1219	43	4		4	CNGA3	2	99013277	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	18483066	99013277	144186096	16	45788											
GALNT13	114805	broad.mit.edu	37	chr2	155102369	155102369	+	Frame_Shift_Del	DEL	C	-	-																															tgatgtgattagtgatgataCttttgaatatatggctgggt																										TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr2:155102369delC	uc002tyr.3	+	7	1298	c.731delC	c.(730-732)ACTfs	p.T244fs	GALNT13_uc002tyt.3_Frame_Shift_Del_p.T244fs|GALNT13_uc010foc.1_Frame_Shift_Del_p.T63fs|GALNT13_uc010fod.2_5'UTR	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	244	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						AGTGATGATACTTTTGAATAT	0.373													---	---	---								-	155102369	-	-	155102369	7	5	250	1	0	1	0	1	0	0	0	0	6246	565	20	0	749	0	GALNT13	2	155102369	Frame_Shift_Del	DEL	C	TCGA-CV-7411-01A-11D-2078-08	56089092	155102369	88097004	17	45789											
SCN1A	6323	broad.mit.edu	37	chr2	166856255	166856255	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctggaatcaactgctgcaTacattatatccatccatcct	11	14	4	12	0	2	0	1	0	1	0	5	1	5	1	3	1	4	2	3	1	5	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr2:166856255T>C	uc010zcz.1	-	22	4301	c.4283A>G	c.(4282-4284)TAT>TGT	p.Y1428C	SCN1A_uc002udo.3_Missense_Mutation_p.Y1308C|SCN1A_uc010fpk.2_Missense_Mutation_p.Y1280C	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1439	III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AACTGCTGCATACATTATATC	0.303													19	58					0	0	0	0	C	166856255	C	C	166856255	3	2	250	1	0	0	0	0	1	0	0	0	13979	1406	49	5	1733	5	SCN1A	2	166856255	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	11753886	166856255	76343118	18	45790											
MAP2	4133	broad.mit.edu	37	chr2	210559592	210559592	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtaccttttacgaaggcActgatgataaagttcgaaga	13	11	11	6	2	0	3	0	2	0	1	1	5	0	3	1	2	2	3	1	2	6	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr2:210559592A>C	uc002vde.1	+	7	2946	c.2698A>C	c.(2698-2700)ACT>CCT	p.T900P	MAP2_uc002vdc.1_Missense_Mutation_p.T900P|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.T896P	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	900					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TTACGAAGGCACTGATGATAA	0.453													11	53					0	0	0	0	C	210559592	C	C	210559592	3	2	250	1	0	0	0	0	1	0	0	0	9288	159	6	5	2712	5	MAP2	2	210559592	Missense_Mutation	SNP	A	TCGA-CV-7411-01A-11D-2078-08	43703337	210559592	32639781	19	45791											
CPS1	1373	broad.mit.edu	37	chr2	211464248	211464248	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagaacagccagatgggttAattctgggcatgggtggcca	10	8	15	8	0	1	2	0	0	1	2	1	2	1	2	2	4	2	3	2	4	2	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr2:211464248A>T	uc002vee.3	+	14	1644	c.1512A>T	c.(1510-1512)TTA>TTT	p.L504F	CPS1_uc010fur.2_Missense_Mutation_p.L510F|CPS1_uc010fus.2_Missense_Mutation_p.L53F	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	504					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CAGATGGGTTAATTCTGGGCA	0.453													18	54					0	0	0	0	T	211464248	T	T	211464248	3	4	250	1	0	0	0	0	1	0	0	0	3838	359	13	5	1588	5	CPS1	2	211464248	Missense_Mutation	SNP	A	TCGA-CV-7411-01A-11D-2078-08	904656	211464248	31735125	20	45792											
ALPP	250	broad.mit.edu	37	chr2	233243766	233243766	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagcctgcacagacagcCgccaagaacctcatcatctt	11	7	7	16	1	3	2	2	0	1	2	3	2	3	2	4	0	5	2	4	0	2	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr2:233243766C>T	uc002vsq.2	+	2	327	c.162C>T	c.(160-162)GCC>GCT	p.A54A	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	54						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		CACAGACAGCCGCCAAGAACC	0.667													22	85					0	0	0	0	T	233243766	T	T	233243766	2	4	250	1	0	0	0	0	0	0	0	1	548	639	23	1		1	ALPP	2	233243766	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08	21779518	233243766	9955607	21	45793											
AGAP1	116987	broad.mit.edu	37	chr2	237032610	237032611	+	Missense_Mutation	DNP	GG	TA	TA																															gcccacgggaacacagctctGgcctacgcccggcaggcctc																										TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr2:237032610_237032611GG>TA	uc002vvs.2	+	18	3013_3014	c.2418_2419GG>TA	c.(2416-2421)CTGGCC>CTTACC	p.A807T	AGAP1_uc002vvt.2_Missense_Mutation_p.A754T	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	807	ANK 2.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						ACACAGCTCTGGCCTACGCCCG	0.644													13	40					0	0	0	0	TA	237032611	TA	TA	237032610	3	4	250	1	0	0	0	0	1	0	0	0	366	1335	47	4	2488	4	AGAP1	2	237032610	Missense_Mutation	DNP	GG	TCGA-CV-7411-01A-11D-2078-08	3788844	237032610	6166763	22	45794											
OR6B3	150681	broad.mit.edu	37	chr2	240984616	240984616	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttaaattccttattcctcaGgcagtatatcaaggggttca	11	14	7	9	0	3	0	3	0	0	0	5	0	5	0	2	3	0	3	2	3	6	7			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr2:240984616G>A	uc010zoe.1	-	1	874	c.874C>T	c.(874-876)CTG>TTG	p.L292L	PRR21_uc010zod.1_5'Flank	NM_173351	NP_775486	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		TTATTCCTCAGGCAGTATATC	0.493													25	121					0	0	0	0	A	240984616	A	A	240984616	2	1	250	1	0	0	0	0	0	0	0	1	11243	991	35	4		4	OR6B3	2	240984616	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	3952006	240984616	2214757	23	45795											
TGFBR2	7048	broad.mit.edu	37	chr3	30715717	30715717	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgctctgggaaatgacaTctcgctgtaatgcagtggga	9	11	14	7	1	2	1	0	1	2	0	3	3	2	3	0	3	2	4	0	3	2	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr3:30715717T>C	uc003ceo.2	+	5	1757	c.1375T>C	c.(1375-1377)TCT>CCT	p.S459P	TGFBR2_uc003cen.2_Missense_Mutation_p.S484P	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	459	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						GGAAATGACATCTCGCTGTAA	0.463													28	48					0	0	0	0	C	30715717	C	C	30715717	3	2	250	1	0	0	0	0	1	0	0	0	15888	1435	50	5	1472	5	TGFBR2	3	30715717	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08		30715717	167306713	24	45796											
STAB1	23166	broad.mit.edu	37	chr3	52552020	52552020	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gccgtgcccgagtcggcctgGtaatgatgcccaagtcagac	8	7	13	13	3	1	2	1	1	0	1	2	3	1	2	4	2	2	1	4	2	2	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr3:52552020G>C	uc003dej.2	+	45	4835	c.4761_splice	c.e45+1	p.L1587_splice	STAB1_uc003dek.1_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor						cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		AGTCGGCCTGGTAATGATGCC	0.612													11	49					0	0	0	0	C	52552020	C	C	52552020	5	2	250	1	0	0	0	0	0	0	1	0	15303	1275	44	4	4940	4	STAB1	3	52552020	Splice_Site	SNP	G	TCGA-CV-7411-01A-11D-2078-08	21836303	52552020	145470410	25	45797											
SEMA5B	54437	broad.mit.edu	37	chr3	122629868	122629868	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaagcaggagatgcccgtgGccaccaagtggatgagattg	12	6	15	8	1	0	3	0	1	0	3	0	6	0	4	3	3	2	1	3	3	2	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr3:122629868G>A	uc003efz.1	-	22	3420	c.3116C>T	c.(3115-3117)GCC>GTC	p.A1039V	SEMA5B_uc011bju.1_Missense_Mutation_p.A945V|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.A1039V|SEMA5B_uc003efy.1_Missense_Mutation_p.A17V	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	1039	Helical; Signal-anchor for type III membrane protein; (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		GATGCCCGTGGCCACCAAGTG	0.597													5	21					0	0	0	0	A	122629868	A	A	122629868	3	1	250	1	0	0	0	0	1	0	0	0	14103	1203	42	4	347	4	SEMA5B	3	122629868	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	70077848	122629868	75392562	26	45798											
A4GNT	51146	broad.mit.edu	37	chr3	137850095	137850095	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagagctggagctccttccGcatgtcctcttctctgtgcc	4	12	11	14	1	2	1	0	0	2	1	6	3	5	2	4	2	3	3	4	2	0	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr3:137850095G>A	uc003ers.2	-	2	206	c.4C>T	c.(4-6)CGG>TGG	p.R2W		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	2	Cytoplasmic (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						AGCTCCTTCCGCATGTCCTCT	0.413													6	26					0	0	0	0	A	137850095	A	A	137850095	3	1	250	1	0	0	0	0	1	0	0	0	7	1086	38	1	1026	1	A4GNT	3	137850095	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	15220227	137850095	60172335	27	45799											
CLSTN2	64084	broad.mit.edu	37	chr3	140185547	140185547	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctgacacctttcgccccGcggagttccactggaagctg	7	8	12	14	3	0	1	0	1	0	0	2	3	1	3	4	3	1	3	4	3	1	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr3:140185547G>A	uc003etn.2	+	8	1508	c.1318G>A	c.(1318-1320)GCG>ACG	p.A440T	CLSTN2_uc003etm.2_Missense_Mutation_p.A440T	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	440	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CTTTCGCCCCGCGGAGTTCCA	0.572										HNSCC(16;0.037)			6	28					0	0	0	0	A	140185547	A	A	140185547	3	1	250	1	0	0	0	0	1	0	0	0	3577	1087	38	1	1348	1	CLSTN2	3	140185547	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	2335452	140185547	57836883	28	45800											
PIK3CA	5290	broad.mit.edu	37	chr3	178928079	178928079	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccagtacctcatggattaGaagatttgctgaaccctatt	11	12	9	9	0	1	3	1	1	0	2	1	4	1	4	3	2	3	2	3	2	5	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr3:178928079G>A	uc003fjk.2	+	8	1514	c.1357G>A	c.(1357-1359)GAA>AAA	p.E453K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	453	C2 PI3K-type.		E -> Q (in cancer; shows an increase in lipid kinase activity; may disrupt the interaction of the C2 PI3K-type domain with the iSH2 region of the p85 regulatory subunit).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E453K(5)|p.E453Q(1)|p.E453A(1)|p.P449_L455del(1)|p.G451_L456>V(1)|p.E453del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCATGGATTAGAAGATTTGCT	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			16	59					0	0	0	0	A	178928079	A	A	178928079	3	1	250	1	0	0	0	0	1	0	0	0	11968	943	33	2	1383	2	PIK3CA	3	178928079	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	38742532	178928079	19094351	29	45801											
BOD1L	259282	broad.mit.edu	37	chr4	13602988	13602988	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcatcatcacaaggaccagCagcaactaatggtacattag	15	9	7	10	0	3	0	3	0	0	0	3	1	3	1	1	2	4	3	1	2	5	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr4:13602988C>A	uc003gmz.1	-	10	5653	c.5536G>T	c.(5536-5538)GCT>TCT	p.A1846S	BOD1L_uc010idr.1_Missense_Mutation_p.A1183S	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1846							DNA binding			ovary(5)|breast(1)	6						CAAGGACCAGCAGCAACTAAT	0.473													14	67					0.000219431	0.000229604	1	0	A	13602988	A	A	13602988	3	1	250	1	0	0	0	0	1	0	0	0	1486	710	25	4	3687	4	BOD1L	4	13602988	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08		13602988	177551288	30	45802											
FRYL	285527	broad.mit.edu	37	chr4	48523208	48523208	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatggtctggtattgtttCatcagtggcagaatcactgt	9	14	12	6	0	4	1	3	0	1	1	4	2	4	2	0	4	0	3	0	4	2	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr4:48523208C>A	uc003gyh.1	-	55	8151	c.7546G>T	c.(7546-7548)GAA>TAA	p.E2516*	FRYL_uc003gyf.1_5'Flank|FRYL_uc003gyg.1_Nonsense_Mutation_p.E1212*|FRYL_uc003gyi.1_Nonsense_Mutation_p.E1404*|FRYL_uc003gyj.1_Nonsense_Mutation_p.E811*	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2516					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GGTATTGTTTCATCAGTGGCA	0.388													12	45					1.5842e-08	1.80075e-08	1	0	A	48523208	A	A	48523208	4	1	250	1	0	0	0	0	0	1	0	0	6098	835	29	2	1535	2	FRYL	4	48523208	Nonsense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	34920220	48523208	142631068	31	45803											
CEP135	9662	broad.mit.edu	37	chr4	56823519	56823519	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgcagacctccttcaagtGgctgataacaggtgcattaa	12	11	9	9	0	1	2	1	1	0	1	2	2	2	2	2	2	3	3	2	2	3	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr4:56823519G>A	uc003hbi.2	+	5	837	c.603G>A	c.(601-603)GTG>GTA	p.V201V	CEP135_uc003hbh.1_Silent_p.V201V|CEP135_uc010igz.1_Silent_p.V31V	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	201	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					TCCTTCAAGTGGCTGATAACA	0.348													11	53					0	0	0	0	A	56823519	A	A	56823519	2	1	250	1	0	0	0	0	0	0	0	1	3262	1335	47	4		4	CEP135	4	56823519	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	8300311	56823519	134330757	32	45804											
SULT1E1	6783	broad.mit.edu	37	chr4	70713465	70713465	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtacacgtggactctttcccTtttcccaccaagattttaca	9	14	5	13	1	1	1	0	0	1	1	3	2	3	2	3	1	2	1	3	1	3	6			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr4:70713465T>C	uc003heo.2	-	6	655	c.542A>G	c.(541-543)AAG>AGG	p.K181R		NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	181					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1						ACTCTTTCCCTTTTCCCACCA	0.373													3	63					0	0	0	0	C	70713465	C	C	70713465	3	2	250	1	0	0	0	0	1	0	0	0	15446	1609	56	5	354	5	SULT1E1	4	70713465	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	13889946	70713465	120440811	33	45805											
HELQ	113510	broad.mit.edu	37	chr4	84348802	84348802	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattagatgaagaaggctttCaagcacaagtccttcaagac	15	9	9	8	0	2	4	2	1	0	3	3	5	3	4	1	1	1	2	1	1	6	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr4:84348802C>T	uc003hom.2	-	13	2769	c.2590G>A	c.(2590-2592)GAA>AAA	p.E864K	HELQ_uc010ikb.2_Missense_Mutation_p.E797K|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	864							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						AGAAGGCTTTCAAGCACAAGT	0.368								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					10	47					0	0	0	0	T	84348802	T	T	84348802	3	4	250	1	0	0	0	0	1	0	0	0	7086	835	29	2	739	2	HELQ	4	84348802	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	13635337	84348802	106805474	34	45806											
FAM190A	401145	broad.mit.edu	37	chr4	91389411	91389411	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaggactcatatcactctGtcgtctcatgtgccgcagta	8	11	11	11	2	4	0	3	0	2	0	6	2	4	2	1	2	1	2	1	2	2	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr4:91389411G>A	uc003hsv.3	+	5	1970	c.1630G>A	c.(1630-1632)GTC>ATC	p.V544I	FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.V544I	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	544										large_intestine(1)|ovary(1)	2						ATATCACTCTGTCGTCTCATG	0.398													4	24					0	0	0	0	A	91389411	A	A	91389411	3	1	250	1	0	0	0	0	1	0	0	0	5549	1377	48	4	1644	4	FAM190A	4	91389411	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	7040609	91389411	99764865	35	45807											
TRPC3	7222	broad.mit.edu	37	chr4	122800994	122800994	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtcttccaaaagttcataaCgaaggctggagatatcttgc	12	12	9	8	1	3	1	1	0	2	1	4	3	4	1	1	2	2	2	1	2	5	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr4:122800994C>T	uc003ieg.2	-	12	2737	c.2663G>A	c.(2662-2664)CGT>CAT	p.R888H	TRPC3_uc010inr.2_Missense_Mutation_p.R760H|TRPC3_uc003ief.2_Missense_Mutation_p.R815H|TRPC3_uc011cgl.1_Missense_Mutation_p.R552H	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	803	Extracellular (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AAGTTCATAACGAAGGCTGGA	0.333													9	28					0	0	0	0	T	122800994	T	T	122800994	3	4	250	1	0	0	0	0	1	0	0	0	16646	536	19	1	106	1	TRPC3	4	122800994	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	31411583	122800994	68353282	36	45808											
FAT4	79633	broad.mit.edu	37	chr4	126336256	126336256	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttgttggatgtaaatgaTaacccaccgacatttctttc	11	16	6	8	1	1	1	0	1	1	0	2	3	1	2	2	1	1	2	2	1	3	7			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr4:126336256T>A	uc003ifj.3	+	5	6138	c.6138T>A	c.(6136-6138)GAT>GAA	p.D2046E	FAT4_uc011cgp.1_Missense_Mutation_p.D344E	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2046	Cadherin 19.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ATGTAAATGATAACCCACCGA	0.408													24	118					0	0	0	0	A	126336256	A	A	126336256	3	1	250	1	0	0	0	0	1	0	0	0	5724	1403	49	5	6156	5	FAT4	4	126336256	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	3535262	126336256	64818020	37	45809											
MCCC2	64087	broad.mit.edu	37	chr5	70948526	70948526	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatgaagcggctttaaaaGagcccatcattaagaagttt	14	11	9	7	1	1	4	1	2	0	2	1	4	1	4	1	1	2	2	1	1	5	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr5:70948526G>T	uc003kbs.3	+	16	1657	c.1519G>T	c.(1519-1521)GAG>TAG	p.E507*	MCCC2_uc003kbt.3_RNA	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	507	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	GGCTTTAAAAGAGCCCATCAT	0.463													9	32					2.17888e-05	2.29508e-05	1	0	T	70948526	T	T	70948526	4	4	250	1	0	0	0	0	0	1	0	0	9428	943	33	2	1581	2	MCCC2	5	70948526	Nonsense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08		70948526	109966734	38	45810											
PCDHB2	56133	broad.mit.edu	37	chr5	140476702	140476702	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagccaattatccccaacttCgttgctcagggtgcagagag	11	9	10	11	1	1	1	1	0	0	1	3	2	2	1	3	1	4	3	3	1	4	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr5:140476702C>T	uc003lil.2	+	1	2466	c.2328C>T	c.(2326-2328)TTC>TTT	p.F776F	PCDHB2_uc003lim.1_Silent_p.F437F	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	776	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCCCAACTTCGTTGCTCAGG	0.507													20	79					0	0	0	0	T	140476702	T	T	140476702	2	4	250	1	0	0	0	0	0	0	0	1	11596	883	31	1		1	PCDHB2	5	140476702	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08	69528176	140476702	40438558	39	45811											
SYNPO	11346	broad.mit.edu	37	chr5	150027825	150027825	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagagccccgacagaggggtCcctggccacagcatggaggg	9	3	16	13	1	0	2	0	0	0	2	1	4	1	3	4	5	2	1	4	5	0	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr5:150027825C>T	uc003lsn.2	+	3	1094	c.720C>T	c.(718-720)GTC>GTT	p.V240V	SYNPO_uc003lso.3_5'UTR|SYNPO_uc003lsp.2_5'UTR	NM_001109974	NP_001103444	Q8N3V7	SYNPO_HUMAN	synaptopodin isoform B	240					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			large_intestine(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACAGAGGGGTCCCTGGCCACA	0.667													10	23					0	0	0	0	T	150027825	T	T	150027825	2	4	250	1	0	0	0	0	0	0	0	1	15522	842	30	2		2	SYNPO	5	150027825	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08	9551123	150027825	30887435	40	45812											
FAT2	2196	broad.mit.edu	37	chr5	150922849	150922849	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatctgcgttctgaccttcAtctgcatcataggccaacac	10	11	6	14	1	5	1	2	1	3	0	5	1	5	1	2	1	3	2	2	1	2	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr5:150922849A>C	uc003lue.3	-	9	7852	c.7839T>G	c.(7837-7839)GAT>GAG	p.D2613E	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2613	Cadherin 23.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCTGACCTTCATCTGCATCAT	0.458													39	154					0	0	0	0	C	150922849	C	C	150922849	3	2	250	1	0	0	0	0	1	0	0	0	5722	214	8	5	5270	5	FAT2	5	150922849	Missense_Mutation	SNP	A	TCGA-CV-7411-01A-11D-2078-08	895024	150922849	29992411	41	45813											
HAVCR2	84868	broad.mit.edu	37	chr5	156514184	156514184	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgacatagcaataatactCattgggctcctccacttcat	11	12	6	12	0	2	1	2	1	0	0	4	1	4	1	2	1	2	3	2	1	4	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr5:156514184C>T	uc003lwk.1	-	7	979	c.835G>A	c.(835-837)GAG>AAG	p.E279K		NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	279	Cytoplasmic (Potential).					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAATAATACTCATTGGGCTCC	0.463													11	43					0	0	0	0	T	156514184	T	T	156514184	3	4	250	1	0	0	0	0	1	0	0	0	7013	835	29	2	74	2	HAVCR2	5	156514184	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	5591335	156514184	24401076	42	45814											
DOCK2	1794	broad.mit.edu	37	chr5	169502981	169502981	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggagctgggattaagatcCatgagaaaagggtgtcagat	13	9	15	4	0	1	3	1	1	0	3	2	6	2	5	1	3	1	1	1	3	3	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr5:169502981C>A	uc003maf.2	+	47	4839	c.4759C>A	c.(4759-4761)CAT>AAT	p.H1587N	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.H1079N|DOCK2_uc003mah.2_Missense_Mutation_p.H143N	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1587	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GATTAAGATCCATGAGAAAAG	0.532													23	107					1.96895e-08	2.2221e-08	1	0	A	169502981	A	A	169502981	3	1	250	1	0	0	0	0	1	0	0	0	4709	594	21	4	4945	4	DOCK2	5	169502981	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	12988797	169502981	11412279	43	45815											
HIST1H4E	8367	broad.mit.edu	37	chr6	26205150	26205150	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtggtctacgcgctgaagaGacagggacgcactctttacg	9	9	13	10	4	2	2	0	1	2	1	2	4	2	3	0	2	2	2	0	2	3	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr6:26205150G>C	uc003ngy.2	+	1	278	c.278G>C	c.(277-279)AGA>ACA	p.R93T		NM_003545	NP_003536	P62805	H4_HUMAN	histone cluster 1, H4e	93					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				GCGCTGAAGAGACAGGGACGC	0.537													6	43					0	0	0	0	C	26205150	C	C	26205150	3	2	250	1	0	0	0	0	1	0	0	0	7208	942	33	2	280	2	HIST1H4E	6	26205150	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08		26205150	144909917	44	45816											
MICB	4277	broad.mit.edu	37	chr6	31474816	31474816	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgccccccatggtgaatGtcacctgcagcgaggtctca	8	8	11	14	1	2	1	2	1	1	0	3	2	2	1	4	2	3	1	4	2	1	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr6:31474816G>A	uc003ntn.3	+	4	747	c.631G>A	c.(631-633)GTC>ATC	p.V211I	MICB_uc011dnm.1_Missense_Mutation_p.V179I|MICB_uc003nto.3_Missense_Mutation_p.V168I	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	211	Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						CATGGTGAATGTCACCTGCAG	0.587													10	42					0	0	0	0	A	31474816	A	A	31474816	3	1	250	1	0	0	0	0	1	0	0	0	9628	1377	48	4	645	4	MICB	6	31474816	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	5269666	31474816	139640251	45	45817											
ENPP1	5167	broad.mit.edu	37	chr6	132195426	132195426	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggaatccctcagaaaggaaAtattgtggaagtggatttca	15	10	11	5	0	2	1	2	0	0	1	3	5	3	5	1	4	0	0	1	4	5	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr6:132195426A>G	uc011ecf.1	+	16	1604	c.1584A>G	c.(1582-1584)AAA>AAG	p.K528K	ENPP1_uc003qcy.2_Silent_p.K158K	NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	528	Phosphodiesterase.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	CAGAAAGGAAATATTGTGGAA	0.259													19	83					0	0	0	0	G	132195426	G	G	132195426	2	3	250	1	0	0	0	0	0	0	0	1	5153	98	4	5		5	ENPP1	6	132195426	Silent	SNP	A	TCGA-CV-7411-01A-11D-2078-08	100720610	132195426	38919641	46	45818											
SYNE1	23345	broad.mit.edu	37	chr6	152647096	152647096	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcccaaaactctgaccttGtgttctgacaatttttcttc	8	16	6	11	0	3	2	0	2	3	0	4	2	3	2	2	1	1	1	2	1	3	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr6:152647096G>T	uc010kiw.2	-	80	16037	c.15435C>A	c.(15433-15435)CAC>CAA	p.H5145Q	SYNE1_uc003qot.3_Missense_Mutation_p.H5074Q|SYNE1_uc003qou.3_Missense_Mutation_p.H5145Q|SYNE1_uc010kiz.2_Missense_Mutation_p.H900Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5145	Spectrin 16.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCTGACCTTGTGTTCTGACA	0.313										HNSCC(10;0.0054)			4	31					0.00024832	0.000256435	1	0	T	152647096	T	T	152647096	3	4	250	1	0	0	0	0	1	0	0	0	15511	1368	48	4	11299	4	SYNE1	6	152647096	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	20451670	152647096	18467971	47	45819											
RBM16	22828	broad.mit.edu	37	chr6	155153217	155153217	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtccggccatctaatgtttCcagtagttctgggattattg	7	15	11	8	1	2	0	0	0	2	0	4	1	4	1	3	3	0	3	3	3	3	6			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr6:155153217C>T	uc003qqa.2	+	21	2736	c.2504C>T	c.(2503-2505)TCC>TTC	p.S835F	TIAM2_uc003qqb.2_5'Flank|RBM16_uc011efj.1_Missense_Mutation_p.S901F|RBM16_uc011efk.1_Missense_Mutation_p.S880F|RBM16_uc003qpz.2_Missense_Mutation_p.S835F|RBM16_uc010kji.2_Intron	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	835	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		TCTAATGTTTCCAGTAGTTCT	0.423													11	84					0	0	0	0	T	155153217	T	T	155153217	3	4	250	1	0	0	0	0	1	0	0	0	13183	855	30	2	2582	2	RBM16	6	155153217	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	2506121	155153217	15961850	48	45820											
HDAC9	9734	broad.mit.edu	37	chr7	18788641	18788641	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttaaaggaattgcctatgaCcccttgatgctgaaacacca	13	10	7	11	0	0	3	0	3	0	0	0	4	0	4	4	1	3	1	4	1	5	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr7:18788641C>T	uc003suh.2	+	13	1955	c.1914C>T	c.(1912-1914)GAC>GAT	p.D638D	HDAC9_uc003sue.2_Silent_p.D638D|HDAC9_uc011jyd.1_Silent_p.D638D|HDAC9_uc003sui.2_Silent_p.D641D|HDAC9_uc003suj.2_Silent_p.D597D|HDAC9_uc003sua.1_Silent_p.D616D|HDAC9_uc010kue.1_Silent_p.D293D	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	638	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TTGCCTATGACCCCTTGATGC	0.428													6	15					0	0	0	0	T	18788641	T	T	18788641	2	4	250	1	0	0	0	0	0	0	0	1	7053	506	18	4		4	HDAC9	7	18788641	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08		18788641	140350022	49	45821											
BBS9	27241	broad.mit.edu	37	chr7	33185916	33185916	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctactattctgggagataaaGaagaatttgatcaaggctgt	14	12	10	5	0	2	4	1	1	1	3	2	5	2	4	0	2	1	1	0	2	7	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr7:33185916G>C	uc003tdn.1	+	2	565	c.52G>C	c.(52-54)GAA>CAA	p.E18Q	BBS9_uc003tdo.1_Missense_Mutation_p.E18Q|BBS9_uc003tdp.1_Missense_Mutation_p.E18Q|BBS9_uc003tdq.1_Missense_Mutation_p.E18Q|BBS9_uc010kwn.1_RNA|BBS9_uc011kan.1_Missense_Mutation_p.E18Q	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	18					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GGGAGATAAAGAAGAATTTGA	0.333									Bardet-Biedl_syndrome				15	58					0	0	0	0	C	33185916	C	C	33185916	3	2	250	1	0	0	0	0	1	0	0	0	1344	943	33	2	54	2	BBS9	7	33185916	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	14397275	33185916	125952747	50	45822											
PKD1L1	168507	broad.mit.edu	37	chr7	47920383	47920383	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagagtatggcttgattgTcactgtctgttctgtaatac	9	15	10	7	0	3	2	1	1	2	1	3	3	3	2	0	1	1	4	0	1	3	6			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr7:47920383T>C	uc003tny.1	-	21	3463	c.3463A>G	c.(3463-3465)ACA>GCA	p.T1155A		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1155	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GGCTTGATTGTCACTGTCTGT	0.468													9	43					0	0	0	0	C	47920383	C	C	47920383	3	2	250	1	0	0	0	0	1	0	0	0	12019	1667	58	5	5234	5	PKD1L1	7	47920383	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	14734467	47920383	111218280	51	45823											
ABCB4	5244	broad.mit.edu	37	chr7	87081037	87081037	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatcccactatgaatcctgCaaaaaacgtggctactgctt	13	10	7	11	1	0	1	0	1	0	0	2	2	2	1	2	1	4	3	2	1	7	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr7:87081037C>T	uc003uiv.1	-	7	686	c.610G>A	c.(610-612)GCA>ACA	p.A204T	ABCB4_uc003uiw.1_Missense_Mutation_p.A204T|ABCB4_uc003uix.1_Missense_Mutation_p.A204T	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	204	Helical; (By similarity).|ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					ATGAATCCTGCAAAAAACGTG	0.443													15	76					0	0	0	0	T	87081037	T	T	87081037	3	4	250	1	0	0	0	0	1	0	0	0	43	710	25	4	3338	4	ABCB4	7	87081037	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	39160654	87081037	72057626	52	45824											
TSGA14	95681	broad.mit.edu	37	chr7	130039889	130039889	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagatcttactaggatgatCtgcaggcccttgctcctctt	9	13	8	11	0	3	2	0	1	3	1	4	3	4	3	2	2	3	2	2	2	3	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr7:130039889C>A	uc003vpz.2	-	10	1011	c.964G>T	c.(964-966)GAT>TAT	p.D322Y	TSGA14_uc003vpy.2_Missense_Mutation_p.D84Y|TSGA14_uc010lmf.2_Missense_Mutation_p.D119Y|TSGA14_uc003vqa.2_Intron|TSGA14_uc011kpg.1_Intron	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	322					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					CTAGGATGATCTGCAGGCCCT	0.383													14	74					1.5842e-08	1.80075e-08	1	0	A	130039889	A	A	130039889	3	1	250	1	0	0	0	0	1	0	0	0	16687	913	32	2	165	2	TSGA14	7	130039889	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	42958852	130039889	29098774	53	45825											
KCNU1	157855	broad.mit.edu	37	chr8	36673194	36673194	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagttcctatgaagcactCaaaggaaagaagtaagtagt	17	8	9	7	0	1	2	1	1	0	1	2	3	2	3	2	1	1	4	2	1	7	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr8:36673194C>G	uc010lvw.2	+	9	1071	c.984C>G	c.(982-984)CTC>CTG	p.L328L	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	328	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ATGAAGCACTCAAAGGAAAGA	0.323													6	26					0	0	0	0	G	36673194	G	G	36673194	2	3	250	1	0	0	0	0	0	0	0	1	8132	813	29	2		2	KCNU1	8	36673194	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08		36673194	109690828	54	45826											
GOT1L1	137362	broad.mit.edu	37	chr8	37793279	37793279	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatgacacgtgcacccgtgTtgggggggtttagccacagg	7	9	16	9	2	0	2	0	2	0	0	0	2	0	2	2	4	2	3	2	4	1	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr8:37793279T>C	uc011lbj.1	-	7	972	c.872A>G	c.(871-873)AAC>AGC	p.N291S		NM_152413	NP_689626	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	291					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			ovary(1)	1	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			TGCACCCGTGTTGGGGGGGTT	0.612													9	22					0	0	0	0	C	37793279	C	C	37793279	3	2	250	1	0	0	0	0	1	0	0	0	6617	1725	60	5	405	5	GOT1L1	8	37793279	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	1120085	37793279	108570743	55	45827											
ARFGEF1	10565	broad.mit.edu	37	chr8	68208832	68208832	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctatgtgttgtgatgttactGcagtaagtaaagcctttaag	11	15	10	5	0	0	1	0	1	0	0	0	1	0	1	1	0	3	5	1	0	6	7			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr8:68208832G>A	uc003xxo.1	-	5	863	c.473C>T	c.(472-474)GCA>GTA	p.A158V		NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	158					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TGATGTTACTGCAGTAAGTAA	0.244													3	31					0	0	0	0	A	68208832	A	A	68208832	3	1	250	1	0	0	0	0	1	0	0	0	852	1319	46	4	5216	4	ARFGEF1	8	68208832	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	30415553	68208832	78155190	56	45828											
NECAB1	64168	broad.mit.edu	37	chr8	91836982	91836982	+	Frame_Shift_Del	DEL	T	-	-																															tttgaagaattcaaagcataTtttgcagatggtgttctcag																										TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr8:91836982delT	uc011lgg.1	+	3	356	c.162delT	c.(160-162)TATfs	p.Y54fs		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	54	EF-hand 1.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			TCAAAGCATATTTTGCAGATG	0.313													---	---	---								-	91836982	-	-	91836982	7	5	250	1	0	1	0	1	0	0	0	0	10358	1500	52	0	172	0	NECAB1	8	91836982	Frame_Shift_Del	DEL	T	TCGA-CV-7411-01A-11D-2078-08	23628150	91836982	54527040	57	45829											
RBM12B	389677	broad.mit.edu	37	chr8	94748464	94748464	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgataaaccctcctgaacGacttatggcacgtcttgcat	10	12	7	12	2	1	2	0	2	1	0	2	3	2	2	2	1	3	2	2	1	4	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr8:94748464G>A	uc003yfz.2	-	3	368	c.175C>T	c.(175-177)CGT>TGT	p.R59C		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	59							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CCTCCTGAACGACTTATGGCA	0.403													31	99					0	0	0	0	A	94748464	A	A	94748464	3	1	250	1	0	0	0	0	1	0	0	0	13179	1058	37	1	2834	1	RBM12B	8	94748464	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	2911482	94748464	51615558	58	45830											
PLEC	5339	broad.mit.edu	37	chr8	144993120	144993122	+	In_Frame_Del	DEL	GAT	-	-																															tctgtcttctcaatgatctcGatgatgatgatgatcatgcg																										TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr8:144993120_144993122delGAT	uc003zaf.1	-	32	11448_11450	c.11278_11280delATC	c.(11278-11280)ATCdel	p.I3760del	PLEC_uc003zab.1_In_Frame_Del_p.I3623del|PLEC_uc003zac.1_In_Frame_Del_p.I3627del|PLEC_uc003zad.2_In_Frame_Del_p.I3623del|PLEC_uc003zae.1_In_Frame_Del_p.I3591del|PLEC_uc003zag.1_In_Frame_Del_p.I3601del|PLEC_uc003zah.2_In_Frame_Del_p.I3609del|PLEC_uc003zaj.2_In_Frame_Del_p.I3650del	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3760	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CAATGATCTCGATGATGATGATG	0.621													---	---	---								-	144993122	-	-	144993120	7	5	250	1	0	1	0	1	0	0	0	0	12107	1048	37	0	2778	0	PLEC	8	144993120	In_Frame_Del	DEL	GAT	TCGA-CV-7411-01A-11D-2078-08	50244656	144993120	1370902	59	45831											
UNC13B	10497	broad.mit.edu	37	chr9	35389887	35389887	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caagggcccagcattcggaaCctggatttctggcccaagct	9	8	11	13	1	1	0	0	0	1	0	2	2	1	2	3	4	3	2	3	4	3	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr9:35389887C>A	uc003zwq.2	+	24	3184	c.2892C>A	c.(2890-2892)AAC>AAA	p.N964K	UNC13B_uc003zwr.2_Missense_Mutation_p.N964K	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	964					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GCATTCGGAACCTGGATTTCT	0.483													23	83					1.50039e-11	1.7431e-11	1	0	A	35389887	A	A	35389887	3	1	250	1	0	0	0	0	1	0	0	0	17053	506	18	4	2986	4	UNC13B	9	35389887	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08		35389887	105823544	60	45832											
KIAA1529	57653	broad.mit.edu	37	chr9	100137790	100137790	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atccaaaacaagattcttctCcagccaacatcatcgatttc	14	11	3	13	1	3	1	1	0	2	1	7	2	4	1	3	0	3	0	3	0	4	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr9:100137790C>A	uc011lut.1	+	48	6083	c.5310C>A	c.(5308-5310)CTC>CTA	p.L1770L	KIAA1529_uc004axe.1_Silent_p.L1576L|KIAA1529_uc004axg.1_Silent_p.L1631L|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Silent_p.L724L	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				AGATTCTTCTCCAGCCAACAT	0.522													14	50					3.27435e-08	3.66913e-08	1	0	A	100137790	A	A	100137790	2	1	250	1	0	0	0	0	0	0	0	1	8279	842	30	2		2	KIAA1529	9	100137790	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08	64747903	100137790	41075641	61	45833											
DBC1	1620	broad.mit.edu	37	chr9	121971050	121971050	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgacagcgtacactgaggccGaaaagcttgcgggcagtgcg	10	5	15	11	5	0	1	0	1	0	0	0	3	0	1	1	2	5	3	1	2	3	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr9:121971050G>A	uc004bkc.2	-	7	1548	c.1092C>T	c.(1090-1092)TTC>TTT	p.F364F		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	364					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CACTGAGGCCGAAAAGCTTGC	0.587													10	35					0	0	0	0	A	121971050	A	A	121971050	2	1	250	1	0	0	0	0	0	0	0	1	4264	1049	37	1		1	DBC1	9	121971050	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	21833260	121971050	19242381	62	45834											
SPTAN1	6709	broad.mit.edu	37	chr9	131345356	131345356	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccccttcttttattcacagGatccatccaacctacaagga	11	11	4	15	0	2	0	1	0	1	0	4	2	4	2	5	2	2	0	5	2	4	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr9:131345356G>T	uc004bvl.3	+	15	1920	c.1807G>T	c.(1807-1809)GAT>TAT	p.D603Y	SPTAN1_uc011mbg.1_Missense_Mutation_p.D603Y|SPTAN1_uc011mbh.1_Missense_Mutation_p.D615Y|SPTAN1_uc004bvm.3_Missense_Mutation_p.D603Y|SPTAN1_uc004bvn.3_Missense_Mutation_p.D603Y	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	603	Spectrin 7.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TTATTCACAGGATCCATCCAA	0.438													8	27					0.00307968	0.00311916	1	0	T	131345356	T	T	131345356	3	4	250	1	0	0	0	0	1	0	0	0	15183	1188	41	2	1861	2	SPTAN1	9	131345356	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	9374306	131345356	9868075	63	45835											
NOTCH1	4851	broad.mit.edu	37	chr9	139401394	139401394	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acggggtcaacggggggattGcagtcgtccacgttgatctc	7	9	15	10	4	2	1	1	1	1	0	5	2	3	2	1	5	2	2	1	5	1	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr9:139401394G>T	uc004chz.2	-	23	3675	c.3675C>A	c.(3673-3675)TGC>TGA	p.C1225*	NOTCH1_uc004cia.1_Nonsense_Mutation_p.C455*	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1225	Extracellular (Potential).|EGF-like 32; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGGGGGGATTGCAGTCGTCCA	0.687			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			3	6					0.00024832	0.000256435	1	0	T	139401394	T	T	139401394	4	4	250	1	0	0	0	0	0	1	0	0	10601	1311	46	4	4040	4	NOTCH1	9	139401394	Nonsense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	8056038	139401394	1812037	64	45836											
KIAA1462	57608	broad.mit.edu	37	chr10	30316132	30316132	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagtggttttgcgtcacttGatcttgaagacattctcgtc	7	15	10	9	2	3	3	1	2	2	1	5	3	3	3	0	1	1	2	0	1	1	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr10:30316132G>C	uc001iux.2	-	2	3004	c.2945C>G	c.(2944-2946)TCA>TGA	p.S982*	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Nonsense_Mutation_p.S844*|KIAA1462_uc009xle.1_Nonsense_Mutation_p.S982*	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	982										ovary(4)	4						TGCGTCACTTGATCTTGAAGA	0.527													29	91					0	0	0	0	C	30316132	C	C	30316132	4	2	250	1	0	0	0	0	0	1	0	0	8273	1294	45	2	1142	2	KIAA1462	10	30316132	Nonsense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08		30316132	105218615	65	45837											
KIAA1462	57608	broad.mit.edu	37	chr10	30316271	30316271	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accgccaccttcttccacgcGaaagcggcccggggatggag	8	5	13	15	5	1	0	0	0	1	0	2	3	2	2	5	4	1	0	5	4	1	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr10:30316271G>A	uc001iux.2	-	2	2865	c.2806C>T	c.(2806-2808)CGC>TGC	p.R936C	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.R798C|KIAA1462_uc009xle.1_Missense_Mutation_p.R936C	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	936										ovary(4)	4						TCTTCCACGCGAAAGCGGCCC	0.607													12	44					0	0	0	0	A	30316271	A	A	30316271	3	1	250	1	0	0	0	0	1	0	0	0	8273	1058	37	1	1281	1	KIAA1462	10	30316271	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	139	30316271	105218476	66	45838											
OGDHL	55753	broad.mit.edu	37	chr10	50952744	50952744	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tatatgcagaatctttttatCcttggacctgccataagcct	10	15	6	10	0	1	1	0	0	1	1	2	2	2	2	4	1	3	1	4	1	5	7			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr10:50952744C>T	uc001jie.2	-	13	1826	c.1684G>A	c.(1684-1686)GAT>AAT	p.D562N	OGDHL_uc009xog.2_Missense_Mutation_p.D589N|OGDHL_uc010qgt.1_Missense_Mutation_p.D505N|OGDHL_uc010qgu.1_Missense_Mutation_p.D353N|OGDHL_uc009xoh.2_Missense_Mutation_p.D353N	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	562					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						ATCTTTTTATCCTTGGACCTG	0.537													15	44					0	0	0	0	T	50952744	T	T	50952744	3	4	250	1	0	0	0	0	1	0	0	0	10894	855	30	2	1392	2	OGDHL	10	50952744	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	20636473	50952744	84582003	67	45839											
ANK3	288	broad.mit.edu	37	chr10	61834987	61834987	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagacaacttaagggcagaGggtgcaaggaacaaagatga	17	5	14	5	0	0	4	0	1	0	3	0	5	0	5	0	3	3	3	0	3	6	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr10:61834987G>T	uc001jky.2	-	37	5844	c.5652C>A	c.(5650-5652)CCC>CCA	p.P1884P	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1884	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TAAGGGCAGAGGGTGCAAGGA	0.443													7	56					1.12685e-05	1.19492e-05	1	0	T	61834987	T	T	61834987	2	4	250	1	0	0	0	0	0	0	0	1	622	987	35	4		4	ANK3	10	61834987	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	10882243	61834987	73699760	68	45840											
PAPSS2	9060	broad.mit.edu	37	chr10	89474820	89474820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttgaccacgtccgagctGaggctgaaactctcccttca	10	9	8	14	2	2	3	1	3	1	0	4	4	3	3	3	1	3	2	3	1	2	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr10:89474820G>A	uc001kex.2	+	6	981	c.718G>A	c.(718-720)GAG>AAG	p.E240K	PAPSS2_uc001kew.2_Missense_Mutation_p.E240K|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	240	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CGTCCGAGCTGAGGCTGAAAC	0.363													15	26					0	0	0	0	A	89474820	A	A	89474820	3	1	250	1	0	0	0	0	1	0	0	0	11489	1291	45	2	740	2	PAPSS2	10	89474820	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	27639833	89474820	46059927	69	45841											
PSD	5662	broad.mit.edu	37	chr10	104164418	104164418	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctaacagcagctgggaagggGggcgcagagaacatagcggc	12	3	17	9	2	0	1	0	0	0	1	0	3	0	2	0	5	5	3	0	5	4	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr10:104164418G>A	uc001kvg.1	-	15	3149	c.2622C>T	c.(2620-2622)CCC>CCT	p.P874P	PSD_uc001kve.1_Silent_p.P82P|PSD_uc001kvf.1_Silent_p.P243P|PSD_uc001kvh.1_Silent_p.P495P|PSD_uc009xxd.1_Silent_p.P874P	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	874					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CTGGGAAGGGGGGCGCAGAGA	0.617													35	99					0	0	0	0	A	104164418	A	A	104164418	2	1	250	1	0	0	0	0	0	0	0	1	12708	1219	43	4		4	PSD	10	104164418	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	14689598	104164418	31370329	70	45842											
SCGB1C1	147199	broad.mit.edu	37	chr11	193783	193783	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactactggtggggaccccaGaggagctctatgaggggacc	9	6	15	11	0	1	2	0	1	1	1	1	5	1	5	3	6	2	1	3	6	2	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr11:193783G>A	uc001loa.1	+	2	147	c.127G>A	c.(127-129)GAG>AAG	p.E43K	ODF3_uc001lob.2_5'Flank|ODF3_uc010qvk.1_5'Flank	NM_145651	NP_663626	Q8TD33	SG1C1_HUMAN	secretoglobin, family 1C, member 1 precursor	43						extracellular region	binding			skin(1)	1		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		GGGGACCCCAGAGGAGCTCTA	0.532													5	50					0	0	0	0	A	193783	A	A	193783	3	1	250	1	0	0	0	0	1	0	0	0	13960	943	33	2	133	2	SCGB1C1	11	193783	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08		193783	134812733	71	45843											
ANO3	63982	broad.mit.edu	37	chr11	26558965	26558966	+	Frame_Shift_Del	DEL	TT	-	-																															ctttgcaggtatccgtaaacTtataaacaatggctcataca																										TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr11:26558965_26558966delTT	uc001mqt.3	+	10	1134_1135	c.989_990delTT	c.(988-990)CTTfs	p.L330fs	ANO3_uc010rdr.1_Frame_Shift_Del_p.L314fs|ANO3_uc010rds.1_Frame_Shift_Del_p.L169fs|ANO3_uc010rdt.1_Frame_Shift_Del_p.L184fs	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	330	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ATCCGTAAACTTATAAACAATG	0.361													---	---	---								-	26558966	-	-	26558965	7	5	250	1	0	1	0	1	0	0	0	0	698	1609	56	0	1027	0	ANO3	11	26558965	Frame_Shift_Del	DEL	TT	TCGA-CV-7411-01A-11D-2078-08	26365182	26558965	108447551	72	45844											
KCNA4	3739	broad.mit.edu	37	chr11	30033675	30033675	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttgggtctcaaagcgtaggCctgacacatttatcaccaca	11	11	8	11	1	2	1	2	1	1	0	3	1	2	1	2	2	1	1	2	2	3	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr11:30033675C>G	uc001msk.2	-	2	1703	c.551G>C	c.(550-552)GGC>GCC	p.G184A		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	184						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAAGCGTAGGCCTGACACATT	0.512													10	47					0	0	0	0	G	30033675	G	G	30033675	3	3	250	1	0	0	0	0	1	0	0	0	8044	739	26	4	1414	4	KCNA4	11	30033675	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	3474710	30033675	104972841	73	45845											
C11orf68	83638	broad.mit.edu	37	chr11	65685181	65685181	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaacacagatgacctggcGcccaccctccttggcacgtg	9	7	10	15	2	0	2	0	1	0	1	1	2	1	2	4	2	1	2	4	2	2	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr11:65685181G>A	uc001ogi.2	-	2	660	c.631C>T	c.(631-633)CGC>TGC	p.R211C	C11orf68_uc009yqv.2_Missense_Mutation_p.R210C|DRAP1_uc001ogj.1_5'Flank	NM_001135635	NP_001129107	Q9H3H3	CK068_HUMAN	basophilic leukemia expressed protein BLES03	169											0				READ - Rectum adenocarcinoma(159;0.166)		ATGACCTGGCGCCCACCCTCC	0.637													8	30					0	0	0	0	A	65685181	A	A	65685181	3	1	250	1	0	0	0	0	1	0	0	0	1664	1087	38	1	254	1	C11orf68	11	65685181	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	35651506	65685181	69321335	74	45846											
UCP2	7351	broad.mit.edu	37	chr11	73689424	73689424	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtggccttgaacccaaccatGatgctgatttcctgctacgt	8	12	9	12	1	0	3	0	3	0	0	1	3	1	3	4	1	5	2	4	1	3	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr11:73689424G>C	uc001oup.1	-	3	380	c.0C>G	c.(-2-2)ATCAT>ATGAT		UCP2_uc001ouq.1_Translation_Start_Site	NM_003355	NP_003346	P55851	UCP2_HUMAN	uncoupling protein 2						proton transport|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding				0	Breast(11;0.000112)					ACCCAACCATGATGCTGATTT	0.527													9	31					0	0	0	0	C	73689424	C	C	73689424	1	2	250	1	0	0	0	0	0	0	0	0	16999	1305	45	2		2	UCP2	11	73689424	Translation_Start_Site	SNP	G	TCGA-CV-7411-01A-11D-2078-08	8004243	73689424	61317092	75	45847											
GRIA4	2893	broad.mit.edu	37	chr11	105797542	105797542	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atatcatcttatactgctaaCctcgctgctttcctgacggt	8	15	6	12	2	2	1	1	1	1	0	4	1	3	1	2	1	4	3	2	1	4	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr11:105797542C>A	uc001pix.2	+	13	2369	c.1923C>A	c.(1921-1923)AAC>AAA	p.N641K	GRIA4_uc001piw.2_Missense_Mutation_p.N641K	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	641	Helical; (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATACTGCTAACCTCGCTGCTT	0.393													8	42					1.58986e-06	1.7324e-06	1	0	A	105797542	A	A	105797542	3	1	250	1	0	0	0	0	1	0	0	0	6809	506	18	4	2006	4	GRIA4	11	105797542	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	32108118	105797542	29208974	76	45848											
RNF214	257160	broad.mit.edu	37	chr11	117152363	117152363	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaggaacggagccaagctGagcagccttcctcaaatccc	11	6	11	13	1	1	2	1	2	0	0	3	4	3	4	4	2	5	2	4	2	3	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr11:117152363G>A	uc001pqt.2	+	10	1329	c.1284G>A	c.(1282-1284)CTG>CTA	p.L428L	RNF214_uc001pqu.2_Silent_p.L428L|RNF214_uc010rxf.1_Silent_p.L273L	NM_207343	NP_997226	Q8ND24	RN214_HUMAN	ring finger protein 214	428							zinc ion binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		GAGCCAAGCTGAGCAGCCTTC	0.453													25	125					0	0	0	0	A	117152363	A	A	117152363	2	1	250	1	0	0	0	0	0	0	0	1	13543	1277	45	2		2	RNF214	11	117152363	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	11354821	117152363	17854153	77	45849											
VPS11	55823	broad.mit.edu	37	chr11	118948900	118948900	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggccaactctgaggagttCatccccatctttgccaataa	11	11	7	12	0	3	1	1	1	2	0	4	2	4	2	4	2	2	1	4	2	4	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr11:118948900C>A	uc010ryx.1	+	12	1821	c.1779C>A	c.(1777-1779)TTC>TTA	p.F593L	VPS11_uc010ryy.1_Missense_Mutation_p.F439L	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	593					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		CTGAGGAGTTCATCCCCATCT	0.532													32	134					4.31634e-10	4.97796e-10	1	0	A	118948900	A	A	118948900	3	1	250	1	0	0	0	0	1	0	0	0	17256	825	29	2	1820	2	VPS11	11	118948900	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	1796537	118948900	16057616	78	45850											
TECTA	7007	broad.mit.edu	37	chr11	121000377	121000377	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggaagtggaattgccttttTtccatccttcggggaagctg	8	13	12	8	1	0	0	0	0	0	0	3	3	2	3	3	4	2	1	3	4	3	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr11:121000377T>C	uc010rzo.1	+	9	2398	c.2398T>C	c.(2398-2400)TTC>CTC	p.F800L		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	800	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ATTGCCTTTTTTCCATCCTTC	0.438													25	69					0	0	0	0	C	121000377	C	C	121000377	3	2	250	1	0	0	0	0	1	0	0	0	15813	1841	64	5	2432	5	TECTA	11	121000377	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	2051477	121000377	14006139	79	45851											
GRIN2B	2904	broad.mit.edu	37	chr12	13715902	13715902	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccggcttgttggtgacaaGggcccggaagtccggcctgg	6	7	16	12	3	0	1	0	1	0	0	1	2	1	2	4	6	0	2	4	6	2	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr12:13715902G>A	uc001rbt.2	-	13	4449	c.4270C>T	c.(4270-4272)CTT>TTT	p.L1424F		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1424	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGGTGACAAGGGCCCGGAAG	0.622													13	27					0	0	0	0	A	13715902	A	A	13715902	3	1	250	1	0	0	0	0	1	0	0	0	6819	1000	35	4	188	4	GRIN2B	12	13715902	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08		13715902	120135993	80	45852											
DDX11	1663	broad.mit.edu	37	chr12	31242845	31242845	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaaaggagctgaggaggaGaagccaaagaggaggaggca	18	1	18	4	0	0	4	0	1	0	3	0	9	0	8	1	6	2	2	1	6	4	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr12:31242845G>A	uc001rjt.1	+	9	1157	c.906G>A	c.(904-906)GAG>GAA	p.E302E	DDX11_uc010sjw.1_3'UTR|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Silent_p.E302E|DDX11_uc001rjs.1_Silent_p.E302E|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Silent_p.E302E|DDX11_uc001rjw.1_Silent_p.E276E|DDX11_uc001rjx.1_5'UTR|DDX11_uc009zjn.1_RNA	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	302	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CTGAGGAGGAGAAGCCAAAGA	0.587										Multiple Myeloma(12;0.14)			6	8					0	0	0	0	A	31242845	A	A	31242845	2	1	250	1	0	0	0	0	0	0	0	1	4360	933	33	2		2	DDX11	12	31242845	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	17526943	31242845	102609050	81	45853											
FMNL3	91010	broad.mit.edu	37	chr12	50043581	50043581	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagcagcatgaagcggtcctCagctgccaactcctccaggg	9	6	12	14	1	1	1	1	1	0	0	4	2	4	1	4	2	6	3	4	2	2	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr12:50043581C>G	uc001ruv.1	-	18	2362	c.2128G>C	c.(2128-2130)GAG>CAG	p.E710Q	FMNL3_uc001ruw.1_Missense_Mutation_p.E659Q|FMNL3_uc001rut.1_Missense_Mutation_p.E276Q|FMNL3_uc001ruu.1_Missense_Mutation_p.E560Q	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	710	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						AAGCGGTCCTCAGCTGCCAAC	0.602													18	63					0	0	0	0	G	50043581	G	G	50043581	3	3	250	1	0	0	0	0	1	0	0	0	5985	835	29	2	991	2	FMNL3	12	50043581	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	18800736	50043581	83808314	82	45854											
PLXNC1	10154	broad.mit.edu	37	chr12	94641745	94641745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtttaaagagttcaaaagtgCgcacgaatgtcactgtgaag	14	10	11	6	2	2	2	2	1	0	1	2	3	2	2	0	0	1	3	0	0	6	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr12:94641745C>T	uc001tdc.2	+	13	2704	c.2455C>T	c.(2455-2457)CGC>TGC	p.R819C		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	819	Extracellular (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						TTCAAAAGTGCGCACGAATGT	0.463													17	62					0	0	0	0	T	94641745	T	T	94641745	3	4	250	1	0	0	0	0	1	0	0	0	12181	768	27	1	2505	1	PLXNC1	12	94641745	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	44598164	94641745	39210150	83	45855											
C12orf42	374470	broad.mit.edu	37	chr12	103795437	103795437	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggcactgctcacaatgggaAtatagcaaggggatttctga	12	10	12	7	0	2	1	1	1	1	0	2	3	2	3	0	4	2	3	0	4	5	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr12:103795437A>C	uc001tjt.2	-	3	183	c.95T>G	c.(94-96)ATT>AGT	p.I32S	C12orf42_uc001tjs.2_RNA|C12orf42_uc009zuf.1_Missense_Mutation_p.I32S|C12orf42_uc001tju.2_5'UTR	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	32										ovary(1)|central_nervous_system(1)	2						CACAATGGGAATATAGCAAGG	0.443													7	18					0	0	0	0	C	103795437	C	C	103795437	3	2	250	1	0	0	0	0	1	0	0	0	1694	101	4	5	1003	5	C12orf42	12	103795437	Missense_Mutation	SNP	A	TCGA-CV-7411-01A-11D-2078-08	9153692	103795437	30056458	84	45856											
MYO1H	283446	broad.mit.edu	37	chr12	109845600	109845600	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttgtcattcttttcaggTgatctgcccgttgacactag	7	15	8	11	1	4	2	2	2	2	0	4	2	4	2	2	1	1	1	2	1	1	6			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr12:109845600T>C	uc010sxn.1	+	9	989	c.989T>C	c.(988-990)GTG>GCG	p.V330A		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						TCTTTTCAGGTGATCTGCCCG	0.373													8	31					0	0	0	0	C	109845600	C	C	109845600	3	2	250	1	0	0	0	0	1	0	0	0	10128	1710	59	5	1023	5	MYO1H	12	109845600	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	6050163	109845600	24006295	85	45857											
GCN1L1	10985	broad.mit.edu	37	chr12	120588998	120588998	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatggcatcagtcagtgcCgccatcatctcctgttgctt	6	13	10	12	1	4	0	3	0	1	0	5	1	4	1	3	2	2	3	3	2	0	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr12:120588998C>A	uc001txo.2	-	34	4273	c.4260G>T	c.(4258-4260)GCG>GCT	p.A1420A		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1420					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGTCAGTGCCGCCATCATCT	0.612													11	62					0.000978159	0.000997091	1	0	A	120588998	A	A	120588998	2	1	250	1	0	0	0	0	0	0	0	1	6334	639	23	3		3	GCN1L1	12	120588998	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08	10743398	120588998	13262897	86	45858											
C1QTNF9B	387911	broad.mit.edu	37	chr13	24465689	24465689	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtaggtgaagtaatagacCccagcaatgtggcacgtgaa	13	8	13	7	1	0	3	0	2	0	1	0	3	0	3	2	3	1	4	2	3	6	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr13:24465689C>A	uc010tcw.1	-	3	741	c.741G>T	c.(739-741)GGG>GGT	p.G247G	MIPEP_uc001uox.3_5'Flank|PCOTH_uc001uoy.2_Intron|PCOTH_uc009zzx.2_Intron|C1QTNF9B_uc010tcv.1_Intron|C1QTNF9B_uc001uoz.1_Intron|C1QTNF9B_uc010tcx.1_Silent_p.G247G	NM_001007537	NP_001007538	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	247	C1q.					collagen					0						AGTAATAGACCCCAGCAATGT	0.408													17	105					2.23348e-06	2.40062e-06	1	0	A	24465689	A	A	24465689	2	1	250	1	0	0	0	0	0	0	0	1	1980	610	22	4		4	C1QTNF9B	13	24465689	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08		24465689	90704189	87	45859											
RXFP2	122042	broad.mit.edu	37	chr13	32367045	32367045	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtaacattcgacctggaaaaCggcagacctcagtcatcctc	12	8	8	13	2	2	1	2	0	0	1	5	3	3	2	3	2	2	2	3	2	3	2	rs142857153	byFrequency	TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr13:32367045C>T	uc001utt.2	+	16	1677	c.1606C>T	c.(1606-1608)CGG>TGG	p.R536W	RXFP2_uc010aba.2_Missense_Mutation_p.R495W	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	536	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		ACCTGGAAAACGGCAGACCTC	0.428													7	31					0	0	0	0	T	32367045	T	T	32367045	3	4	250	1	0	0	0	0	1	0	0	0	13825	527	19	1	1668	1	RXFP2	13	32367045	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	7901356	32367045	82802833	88	45860											
SLC15A1	6564	broad.mit.edu	37	chr13	99376168	99376168	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgagcaccaactcacacGtgcacaggaaggctgtcggg	11	5	13	12	2	1	1	1	1	0	0	2	2	1	2	1	3	3	3	1	3	2	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr13:99376168G>A	uc001vno.2	-	5	440	c.363C>T	c.(361-363)CAC>CAT	p.H121H	SLC15A1_uc001vnp.1_Silent_p.H89H	NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	121	Helical; (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CAACTCACACGTGCACAGGAA	0.512													7	35					0	0	0	0	A	99376168	A	A	99376168	2	1	250	1	0	0	0	0	0	0	0	1	14463	1136	40	1		1	SLC15A1	13	99376168	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	67009123	99376168	15793710	89	45861											
RPGRIP1	57096	broad.mit.edu	37	chr14	21788328	21788328	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtattgcaagagaacactCagatcgaggtaagagcctct	13	9	10	9	1	2	3	1	0	1	3	3	5	2	3	1	1	3	3	1	1	4	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr14:21788328C>G	uc001wag.2	+	11	1459	c.1459C>G	c.(1459-1461)CAG>GAG	p.Q487E	RPGRIP1_uc001wah.2_Missense_Mutation_p.Q129E|RPGRIP1_uc001wai.2_Missense_Mutation_p.Q129E|RPGRIP1_uc001waj.1_5'Flank|RPGRIP1_uc001wak.2_5'Flank|RPGRIP1_uc010aim.2_5'Flank|RPGRIP1_uc001wal.2_5'Flank	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	487	Potential.				response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		AGAGAACACTCAGATCGAGGT	0.448													3	20					0	0	0	0	G	21788328	G	G	21788328	3	3	250	1	0	0	0	0	1	0	0	0	13614	827	29	2	1501	2	RPGRIP1	14	21788328	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08		21788328	85561212	90	45862											
SERPINA1	5265	broad.mit.edu	37	chr14	94847230	94847230	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgtcttcattttccaggaActtggtgatgatatcgtggg	7	16	11	7	1	3	2	1	2	2	0	5	3	4	3	1	3	1	0	1	3	2	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr14:94847230A>C	uc001ycx.3	-	3	1156	c.895T>G	c.(895-897)TTC>GTC	p.F299V	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Missense_Mutation_p.F299V|SERPINA1_uc010aux.2_Missense_Mutation_p.F299V|SERPINA1_uc001ycy.3_Missense_Mutation_p.F299V|SERPINA1_uc010auy.2_Missense_Mutation_p.F299V|SERPINA1_uc001ycz.3_Missense_Mutation_p.F299V|SERPINA1_uc010auz.2_Missense_Mutation_p.F299V|SERPINA1_uc010ava.2_Missense_Mutation_p.F299V|SERPINA1_uc001ydb.3_Missense_Mutation_p.F299V|SERPINA1_uc010avb.2_Missense_Mutation_p.F299V|SERPINA1_uc001ydc.3_Missense_Mutation_p.F299V|SERPINA1_uc001yda.1_Missense_Mutation_p.F299V	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	299					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	TTTTCCAGGAACTTGGTGATG	0.517									Alpha-1-Antitrypsin_Deficiency				10	70					0	0	0	0	C	94847230	C	C	94847230	3	2	250	1	0	0	0	0	1	0	0	0	14151	43	2	5	373	5	SERPINA1	14	94847230	Missense_Mutation	SNP	A	TCGA-CV-7411-01A-11D-2078-08	73058902	94847230	12502310	91	45863											
CLMN	79789	broad.mit.edu	37	chr14	95658065	95658065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcttctcctgagctgttggCcttcctacagaagaaacaca	10	10	9	12	0	1	3	0	1	1	2	3	3	2	3	3	2	3	3	3	2	3	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr14:95658065C>T	uc001yef.2	-	13	2961	c.2845G>A	c.(2845-2847)GCC>ACC	p.A949T		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	949						integral to membrane	actin binding				0				Epithelial(152;0.193)		GAGCTGTTGGCCTTCCTACAG	0.567													9	39					0	0	0	0	T	95658065	T	T	95658065	3	4	250	1	0	0	0	0	1	0	0	0	3557	739	26	4	167	4	CLMN	14	95658065	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	810835	95658065	11691475	92	45864											
TUBGCP5	114791	broad.mit.edu	37	chr15	22861874	22861874	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgatgaagatgcagtccattGctgaaagccatcttgaactg	12	11	10	8	0	1	5	0	4	1	1	2	5	2	5	2	0	4	2	2	0	3	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr15:22861874G>A	uc001yur.3	+	14	2024	c.1894G>A	c.(1894-1896)GCT>ACT	p.A632T	TUBGCP5_uc001yuq.2_Missense_Mutation_p.A632T|TUBGCP5_uc010axz.1_Missense_Mutation_p.A219T	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	632					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		GCAGTCCATTGCTGAAAGCCA	0.458													11	70					0	0	0	0	A	22861874	A	A	22861874	3	1	250	1	0	0	0	0	1	0	0	0	16837	1319	46	4	1948	4	TUBGCP5	15	22861874	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08		22861874	79669518	93	45865											
RYR3	6263	broad.mit.edu	37	chr15	34115205	34115205	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctcccttgcagaaaatgctAgattacctaaaggagaaaaa	17	9	7	8	0	1	3	0	0	1	3	2	4	1	3	2	1	3	2	2	1	8	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr15:34115205A>G	uc001zhi.2	+	81	11074	c.11004A>G	c.(11002-11004)CTA>CTG	p.L3668L	RYR3_uc010bar.2_Silent_p.L3663L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3668					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGAAAATGCTAGATTACCTAA	0.433													5	34					0	0	0	0	G	34115205	G	G	34115205	2	3	250	1	0	0	0	0	0	0	0	1	13835	407	15	5		5	RYR3	15	34115205	Silent	SNP	A	TCGA-CV-7411-01A-11D-2078-08	11253331	34115205	68416187	94	45866											
CEP152	22995	broad.mit.edu	37	chr15	49052415	49052415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgatactctgccagctctgGtagttctcccagccatcgct	6	13	8	14	1	3	1	0	1	3	0	5	1	3	1	3	1	4	4	3	1	2	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr15:49052415G>A	uc001zwy.2	-	19	2645	c.2611C>T	c.(2611-2613)CCA>TCA	p.P871S	CEP152_uc001zwz.2_Missense_Mutation_p.P871S|CEP152_uc001zxa.1_Missense_Mutation_p.P778S	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	871					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		GCCAGCTCTGGTAGTTCTCCC	0.428													17	66					0	0	0	0	A	49052415	A	A	49052415	3	1	250	1	0	0	0	0	1	0	0	0	3263	1261	44	4	2385	4	CEP152	15	49052415	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	14937210	49052415	53478977	95	45867											
RNF111	54778	broad.mit.edu	37	chr15	59350644	59350644	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaatccatctacctctgagCaggcctctgatactgcttca	10	11	6	14	0	4	2	1	2	3	0	5	2	5	2	3	1	4	2	3	1	3	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr15:59350644C>T	uc002afv.2	+	5	1540	c.1261C>T	c.(1261-1263)CAG>TAG	p.Q421*	RNF111_uc002afs.2_Nonsense_Mutation_p.Q421*|RNF111_uc002aft.2_Nonsense_Mutation_p.Q421*|RNF111_uc002afu.2_Nonsense_Mutation_p.Q421*|RNF111_uc002afw.2_Nonsense_Mutation_p.Q421*	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	421	Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		TACCTCTGAGCAGGCCTCTGA	0.443													19	207					0	0	0	0	T	59350644	T	T	59350644	4	4	250	1	0	0	0	0	0	1	0	0	13490	711	25	4	1275	4	RNF111	15	59350644	Nonsense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	10298229	59350644	43180748	96	45868											
IGDCC4	57722	broad.mit.edu	37	chr15	65693167	65693167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcggacccaggacacaaaaGgggtggggtcagctgaggcc	10	4	17	10	1	1	1	1	1	0	0	2	3	1	3	2	7	1	1	2	7	2	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr15:65693167G>A	uc002aou.1	-	5	1028	c.818C>T	c.(817-819)CCT>CTT	p.P273L		NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	273	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GGACACAAAAGGGGTGGGGTC	0.612											OREG0023196	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	71					0	0	0	0	A	65693167	A	A	65693167	3	1	250	1	0	0	0	0	1	0	0	0	7608	1000	35	4	2998	4	IGDCC4	15	65693167	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	6342523	65693167	36838225	97	45869											
CHD2	1106	broad.mit.edu	37	chr15	93547934	93547934	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaagtgaacctgtccccAttggagaggatgaggatgat	12	8	14	7	0	0	4	0	3	0	1	1	8	1	7	3	4	1	0	3	4	2	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr15:93547934A>T	uc002bsp.2	+	34	4941	c.4366A>T	c.(4366-4368)ATT>TTT	p.I1456F	CHD2_uc002bso.1_Missense_Mutation_p.I1456F	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1456					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			ACCTGTCCCCATTGGAGAGGA	0.478													11	71					0	0	0	0	T	93547934	T	T	93547934	3	4	250	1	0	0	0	0	1	0	0	0	3340	217	8	5	4500	5	CHD2	15	93547934	Missense_Mutation	SNP	A	TCGA-CV-7411-01A-11D-2078-08	27854767	93547934	8983458	98	45870											
RGMA	56963	broad.mit.edu	37	chr15	93595681	93595681	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaggctggggcgtggctgcCcgacgtggcgctccagaact	5	7	17	12	4	0	2	0	1	0	1	1	3	1	2	2	5	2	3	2	5	1	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr15:93595681C>A	uc002bss.1	-	3	459	c.187G>T	c.(187-189)GGC>TGC	p.G63C	RGMA_uc002bsq.1_Missense_Mutation_p.G47C|RGMA_uc010boi.1_5'UTR|RGMA_uc002bsr.1_5'UTR|RGMA_uc010urc.1_Missense_Mutation_p.G71C	NM_020211	NP_064596	Q96B86	RGMA_HUMAN	RGM domain family, member A precursor	63					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane					0	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			GCGTGGCTGCCCGACGTGGCG	0.672													3	15					0.00909568	0.00915361	1	0	A	93595681	A	A	93595681	3	1	250	1	0	0	0	0	1	0	0	0	13345	623	22	4	1173	4	RGMA	15	93595681	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	47747	93595681	8935711	99	45871											
TNRC6A	27327	broad.mit.edu	37	chr16	24829935	24829935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcatcctcatccttgaacaCcacgctgccttcaactagtg	9	11	6	15	1	3	1	3	1	0	0	5	1	5	1	4	0	3	1	4	0	3	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr16:24829935C>T	uc002dmm.2	+	21	5108	c.4994C>T	c.(4993-4995)ACC>ATC	p.T1665I	TNRC6A_uc010bxs.2_Missense_Mutation_p.T1412I|TNRC6A_uc002dmn.2_Missense_Mutation_p.T1363I|TNRC6A_uc002dmo.2_Missense_Mutation_p.T1304I	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1665					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TCCTTGAACACCACGCTGCCT	0.532													3	31					0	0	0	0	T	24829935	T	T	24829935	3	4	250	1	0	0	0	0	1	0	0	0	16406	507	18	4	5076	4	TNRC6A	16	24829935	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08		24829935	65524818	100	45872											
ATP2A1	487	broad.mit.edu	37	chr16	28906272	28906272	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagagccaacgcctgcaacTcggtgagcctgcggagcccc	9	4	13	15	3	0	2	0	1	0	1	1	4	0	3	5	2	7	1	5	2	2	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr16:28906272T>C	uc002dro.1	+	12	1601	c.1417T>C	c.(1417-1419)TCG>CCG	p.S473P	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.S473P|ATP2A1_uc002drp.1_Missense_Mutation_p.S348P	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	473	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CGCCTGCAACTCGGTGAGCCT	0.602													4	21					0	0	0	0	C	28906272	C	C	28906272	3	2	250	1	0	0	0	0	1	0	0	0	1138	1551	54	5	1463	5	ATP2A1	16	28906272	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	4076337	28906272	61448481	101	45873											
CCDC135	84229	broad.mit.edu	37	chr16	57762377	57762377	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggccccattcctggcccagCtcccgccaggagagaaacta	9	6	10	16	1	0	1	0	0	0	1	2	3	2	2	6	3	2	1	6	3	2	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr16:57762377C>A	uc002emi.2	+	16	2361	c.2272C>A	c.(2272-2274)CTC>ATC	p.L758I	CCDC135_uc002emj.2_Missense_Mutation_p.L758I|CCDC135_uc002emk.2_Missense_Mutation_p.L693I	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	758						cytoplasm				central_nervous_system(1)	1						CCTGGCCCAGCTCCCGCCAGG	0.602													13	72					2.27111e-07	2.49191e-07	1	0	A	57762377	A	A	57762377	3	1	250	1	0	0	0	0	1	0	0	0	2781	797	28	4	2330	4	CCDC135	16	57762377	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	28856105	57762377	32592376	102	45874											
SDR42E1	93517	broad.mit.edu	37	chr16	82033306	82033306	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatgtagctgactatcctggGaaggtgtctttgttctccag	7	14	12	8	0	2	1	0	1	2	0	4	3	3	2	2	2	1	3	2	2	3	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr16:82033306G>T	uc002fgu.2	-	3	720	c.592C>A	c.(592-594)CCC>ACC	p.P198T		NM_145168	NP_660151	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E,	198					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding				0						ACTATCCTGGGAAGGTGTCTT	0.562													19	100					1.50039e-11	1.7431e-11	1	0	T	82033306	T	T	82033306	3	4	250	1	0	0	0	0	1	0	0	0	14038	1174	41	2	593	2	SDR42E1	16	82033306	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	24270929	82033306	8321447	103	45875											
P2RX1	5023	broad.mit.edu	37	chr17	3802281	3802281	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacaccttgaagaggtgacGgtagttggtcccgttctcca	10	10	11	10	2	1	3	0	2	1	1	3	3	2	3	3	3	1	3	3	3	3	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr17:3802281G>C	uc002fww.2	-	9	1354	c.913C>G	c.(913-915)CGT>GGT	p.R305G		NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	305	Extracellular (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		AAGAGGTGACGGTAGTTGGTC	0.562													20	80					0	0	0	0	C	3802281	C	C	3802281	3	2	250	1	0	0	0	0	1	0	0	0	11393	1116	39	3	302	3	P2RX1	17	3802281	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08		3802281	77392929	104	45876											
GUCY2D	3000	broad.mit.edu	37	chr17	7907216	7907216	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgggtggcgaggagcaGcgctacctcctggaggccgc	5	6	17	13	3	0	0	0	0	0	0	1	3	1	2	3	5	4	3	3	5	1	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr17:7907216G>A	uc002gjt.2	+	3	842	c.768G>A	c.(766-768)CAG>CAA	p.Q256Q		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	256	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				GCGAGGAGCAGCGCTACCTCC	0.692													11	46					0	0	0	0	A	7907216	A	A	7907216	2	1	250	1	0	0	0	0	0	0	0	1	6936	962	34	4		4	GUCY2D	17	7907216	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	4104935	7907216	73287994	105	45877											
DHRS7B	25979	broad.mit.edu	37	chr17	21094308	21094308	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagccctgtggaggtggccCaggatgttcttgctgctgtg	5	11	16	9	0	1	0	0	0	1	0	1	3	1	2	2	4	3	3	2	4	1	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr17:21094308C>G	uc002gyo.2	+	7	847	c.820C>G	c.(820-822)CAG>GAG	p.Q274E		NM_015510	NP_056325	Q6IAN0	DRS7B_HUMAN	dehydrogenase/reductase (SDR family) member 7B	274	Peroxisomal (Potential).					integral to membrane|peroxisomal membrane	binding|oxidoreductase activity			pancreas(1)	1						GGAGGTGGCCCAGGATGTTCT	0.498													17	90					0	0	0	0	G	21094308	G	G	21094308	3	3	250	1	0	0	0	0	1	0	0	0	4518	595	21	4	846	4	DHRS7B	17	21094308	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	13187092	21094308	60100902	106	45878											
NF1	4763	broad.mit.edu	37	chr17	29683523	29683523	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatatcagacacaaaggctcCtaaaaggcaagaaatggaat	19	6	9	7	0	1	2	1	0	0	2	2	4	2	3	1	3	0	2	1	3	7	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr17:29683523C>T	uc002hgg.2	+	52	7994	c.7661C>T	c.(7660-7662)CCT>CTT	p.P2554L	NF1_uc002hgh.2_Missense_Mutation_p.P2533L|NF1_uc010cso.2_Missense_Mutation_p.P742L|NF1_uc010wbt.1_Missense_Mutation_p.P32L|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2554					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ACAAAGGCTCCTAAAAGGCAA	0.358			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			9	49					0	0	0	0	T	29683523	T	T	29683523	3	4	250	1	0	0	0	0	1	0	0	0	10410	681	24	4	7928	4	NF1	17	29683523	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	8589215	29683523	51511687	107	45879											
ACACA	31	broad.mit.edu	37	chr17	35631097	35631097	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacctacctgtagcccatcaTccacatctttcacataacct	12	11	2	16	0	3	0	2	0	1	0	4	0	4	0	5	0	4	1	5	0	4	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr17:35631097T>A	uc002hnm.2	-	9	1075	c.884A>T	c.(883-885)GAT>GTT	p.D295V	ACACA_uc002hnk.2_Missense_Mutation_p.D217V|ACACA_uc002hnl.2_Missense_Mutation_p.D237V|ACACA_uc002hnn.2_Missense_Mutation_p.D295V|ACACA_uc002hno.2_Missense_Mutation_p.D332V|ACACA_uc010cuz.2_Missense_Mutation_p.D295V|ACACA_uc002hnq.2_Missense_Mutation_p.D217V	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	295	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TAGCCCATCATCCACATCTTT	0.433													15	58					0	0	0	0	A	35631097	A	A	35631097	3	1	250	1	0	0	0	0	1	0	0	0	106	1435	50	5	6348	5	ACACA	17	35631097	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	5947574	35631097	45564113	108	45880											
AOC2	314	broad.mit.edu	37	chr17	40997732	40997732	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcagtgtccaggagtgtgtAtctatctatggtgccgattc	7	14	12	8	1	3	0	1	0	2	0	5	2	4	1	2	2	1	1	2	2	3	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr17:40997732A>T	uc002ibu.2	+	1	1124	c.1089A>T	c.(1087-1089)GTA>GTT	p.V363V	AOC2_uc002ibt.2_Silent_p.V363V	NM_009590	NP_033720	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 isoform b	363					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			ovary(2)	2		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		AGGAGTGTGTATCTATCTATG	0.532													28	105					0	0	0	0	T	40997732	T	T	40997732	2	4	250	1	0	0	0	0	0	0	0	1	727	436	16	5		5	AOC2	17	40997732	Silent	SNP	A	TCGA-CV-7411-01A-11D-2078-08	5366635	40997732	40197478	109	45881											
TBX2	6909	broad.mit.edu	37	chr17	59477583	59477583	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcgccatggcttaccacccgTtccacgcgccacggcccgcc	5	5	10	21	6	0	0	0	0	0	0	1	0	1	0	7	2	1	2	7	2	1	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr17:59477583T>A	uc010wox.1	+	1	327	c.46T>A	c.(46-48)TTC>ATC	p.F16I	TBX2_uc002ize.2_Missense_Mutation_p.F6I|TBX2_uc002izg.2_5'UTR	NM_005994	NP_005985	Q13207	TBX2_HUMAN	T-box 2	16					cell aging|positive regulation of cell proliferation		sequence-specific DNA binding				0						TTACCACCCGTTCCACGCGCC	0.567													4	18					0	0	0	0	A	59477583	A	A	59477583	3	1	250	1	0	0	0	0	1	0	0	0	15721	1725	60	5	48	5	TBX2	17	59477583	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	18479851	59477583	21717627	110	45882											
MRC2	9902	broad.mit.edu	37	chr17	60744755	60744755	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgccctccccacagaccaGccggacaaccccagtgagga	10	3	9	19	1	0	2	0	1	0	1	1	4	1	4	8	2	3	0	8	2	1	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr17:60744755G>C	uc002jad.2	+	6	1380	c.978G>C	c.(976-978)CAG>CAC	p.Q326H	MRC2_uc002jac.2_Missense_Mutation_p.Q326H	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	326	Extracellular (Potential).|C-type lectin 1.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCACAGACCAGCCGGACAACC	0.667													5	30					0	0	0	0	C	60744755	C	C	60744755	3	2	250	1	0	0	0	0	1	0	0	0	9811	962	34	4	1000	4	MRC2	17	60744755	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	1267172	60744755	20450455	111	45883											
MYOM1	8736	broad.mit.edu	37	chr18	3102583	3102583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatcacactcgaagttcaatGaaatgactccatcatcatcc	14	11	4	12	1	4	2	4	2	0	0	7	3	6	2	2	0	0	1	2	0	4	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr18:3102583G>A	uc002klp.2	-	23	3798	c.3464C>T	c.(3463-3465)TCA>TTA	p.S1155L	MYOM1_uc002klq.2_Missense_Mutation_p.S1059L	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1155	Ig-like C2-type 3.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GAAGTTCAATGAAATGACTCC	0.428													22	81					0	0	0	0	A	3102583	A	A	3102583	3	1	250	1	0	0	0	0	1	0	0	0	10144	1294	45	2	1657	2	MYOM1	18	3102583	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08		3102583	74974665	112	45884											
SPIRE1	56907	broad.mit.edu	37	chr18	12454464	12454464	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtaagagcgaggcattccaCtgggtagcagaattcctcct	11	9	11	10	1	0	2	0	0	0	2	3	3	3	2	3	2	2	4	3	2	3	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr18:12454464C>T	uc002kre.2	-	13	1704	c.1657G>A	c.(1657-1659)GTG>ATG	p.V553M	SPIRE1_uc002krc.2_RNA|SPIRE1_uc010wzw.1_Missense_Mutation_p.V419M|SPIRE1_uc010wzx.1_Missense_Mutation_p.V342M|SPIRE1_uc010wzy.1_Missense_Mutation_p.V539M	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a	553						cytoskeleton|perinuclear region of cytoplasm	actin binding				0						AGGCATTCCACTGGGTAGCAG	0.453													4	103					0	0	0	0	T	12454464	T	T	12454464	3	4	250	1	0	0	0	0	1	0	0	0	15137	565	20	4	633	4	SPIRE1	18	12454464	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	9351881	12454464	65622784	113	45885											
DSG3	1830	broad.mit.edu	37	chr18	29052346	29052346	+	Frame_Shift_Del	DEL	T	-	-																															tgatggctcagaaggaacaaTtcatcagtggggaattgaag																										TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr18:29052346delT	uc002kws.2	+	13	2106	c.1997delT	c.(1996-1998)ATTfs	p.I666fs	DSG3_uc002kwt.2_5'Flank	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	666	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GAAGGAACAATTCATCAGTGG	0.453													---	---	---								-	29052346	-	-	29052346	7	5	250	1	0	1	0	1	0	0	0	0	4800	1493	52	0	2047	0	DSG3	18	29052346	Frame_Shift_Del	DEL	T	TCGA-CV-7411-01A-11D-2078-08	16597882	29052346	49024902	114	45886											
DSG2	1829	broad.mit.edu	37	chr18	29104786	29104786	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacatttgcatcaggaaatGaaggaggttatttccacata	14	13	8	6	0	1	1	1	1	0	0	2	3	2	3	1	3	2	2	1	3	5	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr18:29104786G>T	uc002kwu.3	+	8	1137	c.949G>T	c.(949-951)GAA>TAA	p.E317*		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	317	Extracellular (Potential).|Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			ATCAGGAAATGAAGGAGGTTA	0.378													12	25					1.08611e-07	1.20849e-07	1	0	T	29104786	T	T	29104786	4	4	250	1	0	0	0	0	0	1	0	0	4799	1291	45	2	979	2	DSG2	18	29104786	Nonsense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	52440	29104786	48972462	115	45887											
MIDN	90007	broad.mit.edu	37	chr19	1257108	1257108	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcgggacgcgcggggtcCgtaccactggtcacccagcc	5	4	15	17	6	1	0	1	0	0	0	2	1	2	1	5	5	2	1	5	5	1	1			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr19:1257108C>T	uc002lrp.2	+	8	1759	c.1244C>T	c.(1243-1245)CCG>CTG	p.P415L		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	415						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCGGGGTCCGTACCACTGG	0.706													4	28					0	0	0	0	T	1257108	T	T	1257108	3	4	250	1	0	0	0	0	1	0	0	0	9632	652	23	1	1270	1	MIDN	19	1257108	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08		1257108	57871875	116	45888											
KHSRP	8570	broad.mit.edu	37	chr19	6416646	6416646	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccgtctgctggtttatggctTtcacattctcgccacctgca	5	14	8	14	2	3	0	1	0	2	0	4	0	3	0	3	2	2	4	3	2	1	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr19:6416646T>A	uc002mer.3	-	14	1453	c.1343A>T	c.(1342-1344)AAA>ATA	p.K448I		NM_003685	NP_003676	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	448	Gly-rich.|KH 4.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			skin(1)	1						GTTTATGGCTTTCACATTCTC	0.602													4	27					0	0	0	0	A	6416646	A	A	6416646	3	1	250	1	0	0	0	0	1	0	0	0	8190	1841	64	5	820	5	KHSRP	19	6416646	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	5159538	6416646	52712337	117	45889			1	69		2	2	18	T		7.523127e-05
KHSRP	8570	broad.mit.edu	37	chr19	6416663	6416663	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctttcacattctcgccaccTgcagaaacgcagaaggtgaa	12	8	9	12	2	2	3	1	1	1	2	3	3	2	3	2	1	2	3	2	1	3	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr19:6416663T>A	uc002mer.3	-	14	1438	c.1328_splice	c.e14-1	p.G443_splice		NM_003685	NP_003676	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein						mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			skin(1)	1						TCTCGCCACCTGCAGAAACGC	0.602													7	30					0	0	0	0	A	6416663	A	A	6416663	5	1	250	1	0	0	0	0	0	0	1	0	8190	1594	55	5	837	5	KHSRP	19	6416663	Splice_Site	SNP	T	TCGA-CV-7411-01A-11D-2078-08	17	6416663	52712320	118	45890			1	69		2	2	18	T		7.523127e-05
AKAP8	10270	broad.mit.edu	37	chr19	15484099	15484099	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggcggtaggggttgtgctCcggcaggcagggcctggagt	4	7	22	8	2	0	0	0	0	0	0	1	1	1	1	2	9	1	5	2	9	1	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr19:15484099C>T	uc002nav.2	-	5	485	c.424G>A	c.(424-426)GAG>AAG	p.E142K	AKAP8_uc010dzy.2_5'UTR|AKAP8_uc010dzz.1_RNA|AKAP8_uc010xog.1_5'UTR	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	142					signal transduction	nuclear matrix				ovary(1)|breast(1)	2						GGGTTGTGCTCCGGCAGGCAG	0.627													4	23					0	0	0	0	T	15484099	T	T	15484099	3	4	250	1	0	0	0	0	1	0	0	0	457	864	30	2	1694	2	AKAP8	19	15484099	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	9067436	15484099	43644884	119	45891											
ZNF98	148198	broad.mit.edu	37	chr19	22575526	22575526	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtatgtcctatcttatgtcTgtttgaatttgaaaatttat	11	20	6	4	0	2	2	0	2	2	0	3	2	3	2	1	0	0	2	1	0	7	7			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr19:22575526T>C	uc002nqt.2	-	4	633	c.511A>G	c.(511-513)AGA>GGA	p.R171G		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				ATCTTATGTCTGTTTGAATTT	0.299													4	17					0	0	0	0	C	22575526	C	C	22575526	3	2	250	1	0	0	0	0	1	0	0	0	18270	1588	55	5	1211	5	ZNF98	19	22575526	Missense_Mutation	SNP	T	TCGA-CV-7411-01A-11D-2078-08	7091427	22575526	36553457	120	45892											
NLRP9	338321	broad.mit.edu	37	chr19	56235505	56235505	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgtccaaagtacacagaaGtaaatctgcaaaagattaaa	20	8	6	7	0	1	2	0	0	1	2	2	2	2	2	1	0	2	3	1	0	9	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr19:56235505G>A	uc002qly.2	-	4	2028	c.2000C>T	c.(1999-2001)ACT>ATT	p.T667I		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	667						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GTACACAGAAGTAAATCTGCA	0.423													4	25					0	0	0	0	A	56235505	A	A	56235505	3	1	250	1	0	0	0	0	1	0	0	0	10538	1029	36	4	999	4	NLRP9	19	56235505	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	33659979	56235505	2893478	121	45893											
NLRP9	338321	broad.mit.edu	37	chr19	56244753	56244753	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcaggaccttccaggacCacagtgtgtcgtctagccgc	8	8	10	15	2	2	0	1	0	1	0	4	2	3	2	5	2	1	0	5	2	1	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr19:56244753C>T	uc002qly.2	-	2	472	c.444G>A	c.(442-444)GTG>GTA	p.V148V		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	148	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CTTCCAGGACCACAGTGTGTC	0.433													7	51					0	0	0	0	T	56244753	T	T	56244753	2	4	250	1	0	0	0	0	0	0	0	1	10538	581	21	4		4	NLRP9	19	56244753	Silent	SNP	C	TCGA-CV-7411-01A-11D-2078-08	9248	56244753	2884230	122	45894											
USP29	57663	broad.mit.edu	37	chr19	57642147	57642147	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaaaccaatacattcgtaGagttcaattttgacagtgtc	15	12	7	7	1	1	3	1	1	0	2	3	3	1	3	1	0	2	2	1	0	6	6			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr19:57642147G>C	uc002qny.2	+	4	2460	c.2104G>C	c.(2104-2106)GAG>CAG	p.E702Q		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	702					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TACATTCGTAGAGTTCAATTT	0.443													15	40					0	0	0	0	C	57642147	C	C	57642147	3	2	250	1	0	0	0	0	1	0	0	0	17127	943	33	2	2106	2	USP29	19	57642147	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	1397394	57642147	1486836	123	45895											
RBCK1	10616	broad.mit.edu	37	chr20	402811	402811	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccgcaacagccaggaggcgGaggtctcctgccccttcatt	7	8	11	15	2	2	0	1	0	1	0	4	2	3	2	5	4	3	1	5	4	1	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr20:402811G>T	uc002wdp.3	+	8	1651	c.958G>T	c.(958-960)GAG>TAG	p.E320*	RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Nonsense_Mutation_p.E278*|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Nonsense_Mutation_p.E150*	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	320	RING-type.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				CCAGGAGGCGGAGGTCTCCTG	0.612													20	72					3.51602e-12	4.14575e-12	1	0	T	402811	T	T	402811	4	4	250	1	0	0	0	0	0	1	0	0	13172	1175	41	2	1007	2	RBCK1	20	402811	Nonsense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08		402811	62622709	124	45896											
PLCG1	5335	broad.mit.edu	37	chr20	39793623	39793623	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcagcattgcccagcagaGaaacatggcccaatacttca	13	7	8	13	0	1	1	1	0	0	1	1	2	1	1	2	1	6	3	2	1	3	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr20:39793623G>A	uc002xjp.1	+	13	1389	c.1268G>A	c.(1267-1269)AGA>AAA	p.R423K	PLCG1_uc002xjo.1_Missense_Mutation_p.R423K|PLCG1_uc010zwe.1_Missense_Mutation_p.R49K|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	423	PI-PLC X-box.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GCCCAGCAGAGAAACATGGCC	0.567													8	33					0	0	0	0	A	39793623	A	A	39793623	3	1	250	1	0	0	0	0	1	0	0	0	12090	942	33	2	1318	2	PLCG1	20	39793623	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	39390812	39793623	23231897	125	45897											
CHRNA4	1137	broad.mit.edu	37	chr20	61978195	61978195	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggtcgatgaccatggccacGtacttccagtcctccttcac	7	10	8	16	3	1	1	1	1	0	0	5	2	4	1	5	2	1	1	5	2	1	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr20:61978195G>A	uc002yes.2	-	6	1957	c.1779C>T	c.(1777-1779)TAC>TAT	p.Y593Y	CHRNA4_uc002yet.1_Silent_p.Y417Y|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.Y522Y|CHRNA4_uc002yev.1_Silent_p.Y417Y|CHRNA4_uc010gkf.1_Silent_p.Y417Y	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	593	Cytoplasmic (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CCATGGCCACGTACTTCCAGT	0.682													3	44					0	0	0	0	A	61978195	A	A	61978195	2	1	250	1	0	0	0	0	0	0	0	1	3400	1140	40	1		1	CHRNA4	20	61978195	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	22184572	61978195	1047325	126	45898											
SFRS15	57466	broad.mit.edu	37	chr21	33063182	33063182	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcctcaggcttgactttgtCccatggaatataagtaacac	11	13	7	10	0	1	1	1	1	0	0	3	2	3	2	2	2	1	2	2	2	4	6			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr21:33063182C>T	uc002ypd.2	-	15	2239	c.1813G>A	c.(1813-1815)GAC>AAC	p.D605N	SFRS15_uc002ype.2_Missense_Mutation_p.D605N|SFRS15_uc010glu.2_Missense_Mutation_p.D590N|SFRS15_uc002ypf.1_Missense_Mutation_p.D279N	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	605				WDK -> CDN (in Ref. 1; AAD09327).		nucleus	nucleotide binding|RNA binding				0						TTGACTTTGTCCCATGGAATA	0.393													21	76					0	0	0	0	T	33063182	T	T	33063182	3	4	250	1	0	0	0	0	1	0	0	0	14236	855	30	2	1654	2	SFRS15	21	33063182	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08		33063182	15066713	127	45899											
SEC14L4	284904	broad.mit.edu	37	chr22	30887573	30887573	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcttacagacgccagcctgGaggcaggtgaggctcccatc	8	7	12	14	1	1	2	0	1	1	1	3	3	2	3	3	4	2	2	3	4	1	1	rs141872549		TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr22:30887573G>A	uc003aid.2	-	11	1168	c.1068C>T	c.(1066-1068)CTC>CTT	p.L356L	SEC14L4_uc011akz.1_Silent_p.L356L|SEC14L4_uc003aie.2_Silent_p.L341L|SEC14L4_uc003aif.2_Silent_p.L302L	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a	356	GOLD.					integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	CGCCAGCCTGGAGGCAGGTGA	0.617													8	76					0	0	0	0	A	30887573	A	A	30887573	2	1	250	1	0	0	0	0	0	0	0	1	14049	1161	41	2		2	SEC14L4	22	30887573	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08		30887573	20416993	128	45900											
SREBF2	6721	broad.mit.edu	37	chr22	42266924	42266924	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcagatcatcaagacagAttcccttgttttgaccacac	11	11	6	13	0	3	4	3	1	0	3	4	4	4	4	3	0	0	1	3	0	1	4			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr22:42266924A>T	uc003bbi.2	+	4	921	c.752A>T	c.(751-753)GAT>GTT	p.D251V	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	251	Interaction with LMNA (By similarity).|Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						ATCAAGACAGATTCCCTTGTT	0.502													23	95					0	0	0	0	T	42266924	T	T	42266924	3	4	250	1	0	0	0	0	1	0	0	0	15208	333	12	5	766	5	SREBF2	22	42266924	Missense_Mutation	SNP	A	TCGA-CV-7411-01A-11D-2078-08	11379351	42266924	9037642	129	45901											
TNFRSF13C	115650	broad.mit.edu	37	chr22	42322147	42322147	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctctgcggaggacgcgccgcGaagccgccgctgtcgccgcc	4	4	15	18	9	1	0	0	0	1	0	2	3	1	2	5	2	2	1	5	2	1	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr22:42322147G>C	uc003bbl.2	-	2	369	c.325C>G	c.(325-327)CGC>GGC	p.R109G	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|TNFRSF13C_uc010gyp.1_Missense_Mutation_p.R110G	NM_052945	NP_443177	Q96RJ3	TR13C_HUMAN	BAFF receptor	109	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						GACGCGCCGCGAAGCCGCCGC	0.602													5	23					0	0	0	0	C	42322147	C	C	42322147	3	2	250	1	0	0	0	0	1	0	0	0	16354	1058	37	3	237	3	TNFRSF13C	22	42322147	Missense_Mutation	SNP	G	TCGA-CV-7411-01A-11D-2078-08	55223	42322147	8982419	130	45902											
TNFRSF13C	115650	broad.mit.edu	37	chr22	42322238	42322238	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcagcgcgggggcgccaaaGagcagcccgggcaggggcag	9	0	20	12	4	0	1	0	0	0	1	0	1	0	1	2	5	4	4	2	5	1	0			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr22:42322238G>C	uc003bbl.2	-	2	278	c.234C>G	c.(232-234)CTC>CTG	p.L78L	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|TNFRSF13C_uc010gyp.1_Silent_p.L79L	NM_052945	NP_443177	Q96RJ3	TR13C_HUMAN	BAFF receptor	78	Extracellular (Potential).					integral to membrane	receptor activity				0						GGGCGCCAAAGAGCAGCCCGG	0.662													3	6					0	0	0	0	C	42322238	C	C	42322238	2	2	250	1	0	0	0	0	0	0	0	1	16354	929	33	2		2	TNFRSF13C	22	42322238	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	91	42322238	8982328	131	45903											
EFCAB6	64800	broad.mit.edu	37	chr22	44063042	44063042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccttgctgaagtcaagaaatCgttttttgaatgccgggtcc	9	13	10	9	2	1	3	1	2	0	1	3	3	2	3	3	1	2	2	3	1	4	4	rs148107489	byFrequency	TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chr22:44063042C>T	uc003bdy.1	-	17	2140	c.1925G>A	c.(1924-1926)CGA>CAA	p.R642Q	EFCAB6_uc003bdz.1_Missense_Mutation_p.R490Q|EFCAB6_uc010gzi.1_Missense_Mutation_p.R490Q|EFCAB6_uc010gzj.1_5'UTR|EFCAB6_uc010gzk.1_RNA	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	642	EF-hand 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				GTCAAGAAATCGTTTTTTGAA	0.403													13	110					0	0	0	0	T	44063042	T	T	44063042	3	4	250	1	0	0	0	0	1	0	0	0	4961	884	31	1	2644	1	EFCAB6	22	44063042	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	1740804	44063042	7241524	132	45904											
ATP7A	538	broad.mit.edu	37	chrX	77245061	77245061	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagtagtttctttagagaatAggtctgccattgtgaagtat	11	16	10	4	0	2	2	0	1	2	1	2	3	2	2	1	1	1	3	1	1	7	8			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chrX:77245061A>T	uc004ecx.3	+	4	1103	c.943A>T	c.(943-945)AGG>TGG	p.R315W	ATP7A_uc004ecw.2_Missense_Mutation_p.R315W	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	315	HMA 3.|Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TTTAGAGAATAGGTCTGCCAT	0.388													34	166					0	0	0	0	T	77245061	T	T	77245061	3	4	250	1	0	0	0	0	1	0	0	0	1192	411	15	5	953	5	ATP7A	23	77245061	Missense_Mutation	SNP	A	TCGA-CV-7411-01A-11D-2078-08		77245061	78025499	133	45905											
DRP2	1821	broad.mit.edu	37	chrX	100497333	100497333	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgttcaaagaagaattctCccccatgaaagatggagtaa	15	9	9	8	0	2	4	1	1	1	3	3	5	2	5	2	1	0	3	2	1	5	3			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chrX:100497333C>A	uc004egz.2	+	8	1217	c.848C>A	c.(847-849)TCC>TAC	p.S283Y	DRP2_uc011mrh.1_Missense_Mutation_p.S205Y	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	283	Spectrin 2.				central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						GAAGAATTCTCCCCCATGAAA	0.478													46	226					8.20599e-20	9.74847e-20	1	0	A	100497333	A	A	100497333	3	1	250	1	0	0	0	0	1	0	0	0	4786	855	30	2	870	2	DRP2	23	100497333	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	23252272	100497333	54773227	134	45906											
KIAA1210	57481	broad.mit.edu	37	chrX	118222748	118222748	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaaactttttgattctgaGaagacttcttgttcatcttc	11	17	5	8	0	4	3	1	2	3	2	5	4	4	3	0	0	1	1	0	0	3	7			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chrX:118222748G>A	uc004era.3	-	11	2445	c.2445C>T	c.(2443-2445)TTC>TTT	p.F815F		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	815										ovary(4)|skin(1)	5						TTGATTCTGAGAAGACTTCTT	0.483													6	28					0	0	0	0	A	118222748	A	A	118222748	2	1	250	1	0	0	0	0	0	0	0	1	8253	933	33	2		2	KIAA1210	23	118222748	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	17725415	118222748	37047812	135	45907											
GPR112	139378	broad.mit.edu	37	chrX	135428693	135428693	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctatgtagcacattggacttCagagacatctgagggaattt	12	12	10	7	0	2	2	1	1	1	1	2	5	2	4	0	2	1	2	0	2	3	5			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chrX:135428693C>T	uc004ezu.1	+	6	3119	c.2828C>T	c.(2827-2829)TCA>TTA	p.S943L	GPR112_uc010nsb.1_Missense_Mutation_p.S738L|GPR112_uc010nsc.1_Missense_Mutation_p.S710L	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	943	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CATTGGACTTCAGAGACATCT	0.423													36	168					0	0	0	0	T	135428693	T	T	135428693	3	4	250	1	0	0	0	0	1	0	0	0	6667	838	29	2	2838	2	GPR112	23	135428693	Missense_Mutation	SNP	C	TCGA-CV-7411-01A-11D-2078-08	17205945	135428693	19841867	136	45908											
L1CAM	3897	broad.mit.edu	37	chrX	153135917	153135917	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggctgctggagttggtgggGaagagcaggcgcggcttcct	5	9	19	8	2	0	1	0	0	0	1	1	3	1	3	1	7	2	5	1	7	1	2			TCGA-CV-7411-01A-11D-2078-08	TCGA-CV-7411-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	790e387e-9e87-48d0-bc9d-2bc92f20abc5	4b6c7938-cf69-4026-89db-605d1a31ac18	g.chrX:153135917G>A	uc004fjb.2	-	7	840	c.732C>T	c.(730-732)TTC>TTT	p.F244F	L1CAM_uc004fjc.2_Silent_p.F244F|L1CAM_uc010nuo.2_Silent_p.F239F|L1CAM_uc004fjd.1_Silent_p.F58F|L1CAM_uc004fje.1_Silent_p.F239F	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	244	Extracellular (Potential).|Ig-like C2-type 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTTGGTGGGGAAGAGCAGGC	0.592													9	36					0	0	0	0	A	153135917	A	A	153135917	2	1	250	1	0	0	0	0	0	0	0	1	8628	1165	41	2		2	L1CAM	23	153135917	Silent	SNP	G	TCGA-CV-7411-01A-11D-2078-08	17707224	153135917	2134643	137	45909											
UBE4B	10277	broad.mit.edu	37	chr1	10239993	10239993	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attcaggcgtggatgagagaGaaacagaacagcgatcacta	16	6	12	7	2	2	3	2	1	0	3	2	7	2	4	0	2	3	0	0	2	3	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:10239993G>A	uc001aqs.3	+	28	4601	c.3888G>A	c.(3886-3888)GAG>GAA	p.E1296E	UBE4B_uc001aqr.3_Silent_p.E1167E|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Silent_p.E751E|UBE4B_uc001aqu.2_Silent_p.E177E	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	1296					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GGATGAGAGAGAAACAGAACA	0.552													8	40					0	0	0	0	A	10239993	A	A	10239993	2	1	251	1	0	0	0	0	0	0	0	1	16951	933	33	2		2	UBE4B	1	10239993	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08		10239993	239010628	1	45910											
PTCHD2	57540	broad.mit.edu	37	chr1	11561896	11561896	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctcatcttcctggcgcgcGgcgacgcggagcgcaacatt	7	7	13	14	7	2	0	1	0	1	0	3	2	3	1	1	3	3	2	1	3	1	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:11561896G>A	uc001ash.3	+	2	985	c.847G>A	c.(847-849)GGC>AGC	p.G283S	PTCHD2_uc001asi.1_Missense_Mutation_p.G283S	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	283	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCTGGCGCGCGGCGACGCGGA	0.647													5	20					0	0	0	0	A	11561896	A	A	11561896	3	1	251	1	0	0	0	0	1	0	0	0	12795	1116	39	1	849	1	PTCHD2	1	11561896	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	1321903	11561896	237688725	2	45911											
ARHGEF10L	55160	broad.mit.edu	37	chr1	18023742	18023742	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcccaccgcaaggagatttGctctgtggccatcatctccg	7	9	10	15	3	3	1	1	0	2	1	4	2	3	1	4	2	1	2	4	2	1	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:18023742G>T	uc001ban.2	+	29	3866	c.3707G>T	c.(3706-3708)TGC>TTC	p.C1236F	ARHGEF10L_uc001bao.2_Missense_Mutation_p.C1197F|ARHGEF10L_uc001bap.2_Missense_Mutation_p.C1192F|ARHGEF10L_uc001baq.2_Missense_Mutation_p.C997F|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.C1009F|ARHGEF10L_uc001bar.2_Missense_Mutation_p.C939F|ARHGEF10L_uc009vpf.2_RNA|ARHGEF10L_uc001bas.2_Missense_Mutation_p.C260F	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	1236					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		AAGGAGATTTGCTCTGTGGCC	0.687													13	31					7.03913e-09	7.84569e-09	1	0	T	18023742	T	T	18023742	3	4	251	1	0	0	0	0	1	0	0	0	895	1319	46	4	3817	4	ARHGEF10L	1	18023742	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	6461846	18023742	231226879	3	45912											
KPNA6	23633	broad.mit.edu	37	chr1	32628883	32628883	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgccctgagagccgtgggtaAcatcgtcactggggatgaca	9	8	14	10	2	1	2	1	2	0	1	2	4	1	3	2	3	3	1	2	3	1	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:32628883A>G	uc001bug.2	+	10	1047	c.959A>G	c.(958-960)AAC>AGC	p.N320S	KPNA6_uc001buh.2_Missense_Mutation_p.N95S|KPNA6_uc010ogx.1_Missense_Mutation_p.N317S|KPNA6_uc010ogy.1_Missense_Mutation_p.N325S|KPNA6_uc009vtz.2_Missense_Mutation_p.N215S	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	320	NLS binding site (minor) (By similarity).|ARM 6.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GCCGTGGGTAACATCGTCACT	0.542													6	18					0	0	0	0	G	32628883	G	G	32628883	3	3	251	1	0	0	0	0	1	0	0	0	8473	43	2	5	997	5	KPNA6	1	32628883	Missense_Mutation	SNP	A	TCGA-CV-7413-01A-11D-2078-08	14605141	32628883	216621738	4	45913											
MAEL	84944	broad.mit.edu	37	chr1	166985521	166985521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agctgtttgcaagaagattgCgtaagttggggaaaggagtt	12	11	15	3	1	0	2	0	0	0	2	0	4	0	4	0	3	3	6	0	3	4	5			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:166985521C>T	uc001gdy.1	+	9	979	c.908C>T	c.(907-909)GCG>GTG	p.A303V	MAEL_uc001gdz.1_Missense_Mutation_p.A272V|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	303					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						AAGAAGATTGCGTAAGTTGGG	0.368													11	52					0	0	0	0	T	166985521	T	T	166985521	3	4	251	1	0	0	0	0	1	0	0	0	9205	782	27	1	942	1	MAEL	1	166985521	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	134356638	166985521	82265100	5	45914											
DUSP27	92235	broad.mit.edu	37	chr1	167095880	167095880	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagagcaagagagaggaggcGgcagacaggagctcagaagc	16	1	17	7	1	1	5	1	0	0	5	1	8	1	7	0	4	3	3	0	4	3	0			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:167095880G>A	uc001geb.1	+	5	1512	c.1512G>A	c.(1510-1512)GCG>GCA	p.A504A		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	504					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GAGAGGAGGCGGCAGACAGGA	0.602													11	29					0	0	0	0	A	167095880	A	A	167095880	2	1	251	1	0	0	0	0	0	0	0	1	4846	1103	39	1		1	DUSP27	1	167095880	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08	110359	167095880	82154741	6	45915											
RASAL2	9462	broad.mit.edu	37	chr1	178411963	178411963	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagcagacaatattttctggGgcgaacattttgaattcttc	12	14	8	7	1	2	2	0	1	2	1	3	3	2	2	0	2	2	1	0	2	5	7			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:178411963G>A	uc001glr.2	+	6	762	c.637G>A	c.(637-639)GGC>AGC	p.G213S	RASAL2_uc001glq.2_Missense_Mutation_p.G361S	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	213	C2.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						TATTTTCTGGGGCGAACATTT	0.388													16	84					0	0	0	0	A	178411963	A	A	178411963	3	1	251	1	0	0	0	0	1	0	0	0	13129	1232	43	4	1128	4	RASAL2	1	178411963	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	11316083	178411963	70838658	7	45916											
CYB5R1	51706	broad.mit.edu	37	chr1	202935050	202935050	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacatagccttgatcctcatCactggtgacaggagtgtatg	10	11	10	10	0	2	2	2	2	0	0	3	3	3	3	2	2	1	1	2	2	2	3			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:202935050C>T	uc001gyt.2	-	4	381	c.310G>A	c.(310-312)GAT>AAT	p.D104N	CYB5R1_uc010pqe.1_RNA	NM_016243	NP_057327	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	104	FAD-binding FR-type.				sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.141)			TGATCCTCATCACTGGTGACA	0.507													6	26					0	0	0	0	T	202935050	T	T	202935050	3	4	251	1	0	0	0	0	1	0	0	0	4143	826	29	2	631	2	CYB5R1	1	202935050	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	24523087	202935050	46315571	8	45917											
GALNT2	2590	broad.mit.edu	37	chr1	230381875	230381875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acaactttcagtatgtggggGcatctgctgacttgaagggc	9	11	13	8	0	2	2	1	2	1	0	2	2	2	2	0	3	2	3	0	3	3	3			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr1:230381875G>A	uc010pwa.1	+	8	868	c.796G>A	c.(796-798)GCA>ACA	p.A266T	GALNT2_uc010pvy.1_Missense_Mutation_p.A228T|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	266	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GTATGTGGGGGCATCTGCTGA	0.493													9	45					0	0	0	0	A	230381875	A	A	230381875	3	1	251	1	0	0	0	0	1	0	0	0	6248	1203	42	4	826	4	GALNT2	1	230381875	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	27446825	230381875	18868746	9	45918											
NT5C1B	93034	broad.mit.edu	37	chr2	18757571	18757571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccccatcaaaggctacaCggagctgagtgtcacagtaa	13	7	9	12	1	2	1	2	1	0	0	3	2	3	2	2	2	2	3	2	2	3	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr2:18757571C>T	uc002rcz.2	-	9	1492	c.1388G>A	c.(1387-1389)CGT>CAT	p.R463H	NT5C1B_uc002rcy.2_Missense_Mutation_p.R463H|NT5C1B_uc010exr.2_Missense_Mutation_p.R405H|NT5C1B_uc010yju.1_Missense_Mutation_p.R403H|NT5C1B_uc002rda.2_Missense_Mutation_p.R403H|NT5C1B_uc010yjv.1_Missense_Mutation_p.R480H|NT5C1B_uc010yjw.1_Missense_Mutation_p.R446H|NT5C1B_uc010exs.2_Missense_Mutation_p.R465H	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	463					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AAAGGCTACACGGAGCTGAGT	0.443													11	31					0	0	0	0	T	18757571	T	T	18757571	3	4	251	1	0	0	0	0	1	0	0	0	10740	536	19	1	452	1	NT5C1B	2	18757571	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08		18757571	224441802	10	45919											
VWA3B	200403	broad.mit.edu	37	chr2	98914449	98914449	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accaaggtcgtgtccacctcCttcatcacgcctgtgggggg	6	9	12	14	2	2	0	2	0	0	0	5	0	4	0	5	4	0	0	5	4	1	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr2:98914449C>T	uc002syo.2	+	24	3501	c.3237C>T	c.(3235-3237)TCC>TCT	p.S1079S	VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Silent_p.S736S|VWA3B_uc002syp.1_Silent_p.S471S|VWA3B_uc002syq.1_Silent_p.S355S|VWA3B_uc002syr.1_Silent_p.S396S|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1079										ovary(3)|large_intestine(2)|skin(1)	6						TGTCCACCTCCTTCATCACGC	0.577													9	59					0	0	0	0	T	98914449	T	T	98914449	2	4	251	1	0	0	0	0	0	0	0	1	17309	668	24	4		4	VWA3B	2	98914449	Silent	SNP	C	TCGA-CV-7413-01A-11D-2078-08	80156878	98914449	144284924	11	45920											
LRP1B	53353	broad.mit.edu	37	chr2	141806672	141806672	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgaaagtctaaagcacgagGgtttaccagattttctatgg	12	12	11	6	1	2	2	0	1	2	1	2	3	2	2	1	2	2	2	1	2	5	6			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr2:141806672G>T	uc002tvj.1	-	11	2644	c.1672C>A	c.(1672-1674)CCT>ACT	p.P558T	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	558	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAAGCACGAGGGTTTACCAGA	0.438										TSP Lung(27;0.18)			31	116					1.61788e-16	1.84163e-16	1	0	T	141806672	T	T	141806672	3	4	251	1	0	0	0	0	1	0	0	0	9005	1232	43	4	12451	4	LRP1B	2	141806672	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	42892223	141806672	101392701	12	45921											
FIGN	55137	broad.mit.edu	37	chr2	164467771	164467771	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtagaatgcaaatatgatcCgttgtatcctggggcatatt	12	13	10	6	1	0	2	0	1	0	1	2	2	2	2	2	2	1	5	2	2	6	6			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr2:164467771C>T	uc002uck.1	-	3	882	c.571G>A	c.(571-573)GGA>AGA	p.G191R		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	191						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						AAATATGATCCGTTGTATCCT	0.507													6	39					0	0	0	0	T	164467771	T	T	164467771	3	4	251	1	0	0	0	0	1	0	0	0	5923	661	23	1	1712	1	FIGN	2	164467771	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	22661099	164467771	78731602	13	45922											
CASP8	841	broad.mit.edu	37	chr2	202131394	202131394	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaagcaatctgtccttccTgaaggagctgctcttccgaa	10	10	10	11	1	2	1	0	1	2	0	5	4	5	3	3	2	3	3	3	2	4	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr2:202131394T>C	uc002uxr.1	+	3	394	c.185T>C	c.(184-186)CTG>CCG	p.L62P	CASP8_uc010ftc.1_Missense_Mutation_p.L62P|CASP8_uc002uxo.1_Missense_Mutation_p.L62P|CASP8_uc002uxp.1_Missense_Mutation_p.L62P|CASP8_uc002uxq.1_Missense_Mutation_p.L62P|CASP8_uc002uxs.1_Missense_Mutation_p.L62P|CASP8_uc002uxt.1_Missense_Mutation_p.L121P|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.L62P|CASP8_uc002uxw.1_Missense_Mutation_p.L62P|CASP8_uc002uxy.1_Missense_Mutation_p.L62P|CASP8_uc002uxx.1_Missense_Mutation_p.L62P|CASP8_uc010ftf.2_Missense_Mutation_p.L62P	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	62	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CTGTCCTTCCTGAAGGAGCTG	0.453										HNSCC(4;0.00038)			6	23					0	0	0	0	C	202131394	C	C	202131394	3	2	251	1	0	0	0	0	1	0	0	0	2689	1580	55	5	368	5	CASP8	2	202131394	Missense_Mutation	SNP	T	TCGA-CV-7413-01A-11D-2078-08	37663623	202131394	41067979	14	45923											
ERC2	26059	broad.mit.edu	37	chr3	56044571	56044571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatctcttctagtctttccCgatcatctctttctcgctgt	4	19	4	14	2	6	0	1	0	5	0	10	1	7	0	1	0	0	1	1	0	2	5			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr3:56044571C>T	uc003dhr.1	-	9	2082	c.1826G>A	c.(1825-1827)CGG>CAG	p.R609Q	ERC2_uc003dht.1_Missense_Mutation_p.R80Q	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	609	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TAGTCTTTCCCGATCATCTCT	0.413													13	49					0	0	0	0	T	56044571	T	T	56044571	3	4	251	1	0	0	0	0	1	0	0	0	5235	652	23	1	1073	1	ERC2	3	56044571	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08		56044571	141977859	15	45924											
TIPARP	25976	broad.mit.edu	37	chr3	156396202	156396202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccacactcaccaagagaacgGaattgaaatttgcatggact	15	8	8	10	1	1	2	1	1	0	1	1	5	1	4	2	2	2	1	2	2	4	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr3:156396202G>A	uc003fav.2	+	2	964	c.716G>A	c.(715-717)GGA>GAA	p.G239E	LOC100287227_uc011boq.1_5'Flank|TIPARP_uc003faw.2_Missense_Mutation_p.G239E	NM_015508	NP_056323	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	239	C3H1-type.						NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|breast(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CAAGAGAACGGAATTGAAATT	0.458													22	127					0	0	0	0	A	156396202	A	A	156396202	3	1	251	1	0	0	0	0	1	0	0	0	15990	1174	41	2	718	2	TIPARP	3	156396202	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	100351631	156396202	41626228	16	45925											
FAT4	79633	broad.mit.edu	37	chr4	126371855	126371855	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gactctggaacaaatgctgtGattgcgtatactgtacagtc	11	12	10	8	1	1	1	0	1	1	0	2	3	1	2	0	1	5	3	0	1	5	4			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr4:126371855G>C	uc003ifj.3	+	9	9684	c.9684G>C	c.(9682-9684)GTG>GTC	p.V3228V	FAT4_uc011cgp.1_Silent_p.V1526V|FAT4_uc003ifi.1_Silent_p.V706V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3228	Cadherin 31.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CAAATGCTGTGATTGCGTATA	0.428													9	50					0	0	0	0	C	126371855	C	C	126371855	2	2	251	1	0	0	0	0	0	0	0	1	5724	1277	45	2		2	FAT4	4	126371855	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08		126371855	64782421	17	45926											
LRBA	987	broad.mit.edu	37	chr4	151842388	151842388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaagttaaaaaaggcatcagGaccatacttctgaggcatat	17	9	8	7	0	2	1	1	1	1	0	2	2	2	2	1	3	1	3	1	3	6	4			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr4:151842388G>A	uc010ipj.2	-	5	1081	c.607C>T	c.(607-609)CCT>TCT	p.P203S	LRBA_uc003ilu.3_Missense_Mutation_p.P203S|LRBA_uc010ipk.1_Missense_Mutation_p.P122S	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	203						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					AAGGCATCAGGACCATACTTC	0.383													25	52					0	0	0	0	A	151842388	A	A	151842388	3	1	251	1	0	0	0	0	1	0	0	0	8981	1174	41	2	8200	2	LRBA	4	151842388	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	25470533	151842388	39311888	18	45927											
FAT1	2195	broad.mit.edu	37	chr4	187549812	187549812	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgatccacagcactgatttGcaaaatttctgtttctggcg	9	14	8	10	1	2	2	0	2	2	0	3	2	3	2	1	1	2	3	1	1	2	3			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr4:187549812G>A	uc003izf.2	-	8	4617	c.4429C>T	c.(4429-4431)CAA>TAA	p.Q1477*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1477	Extracellular (Potential).|Cadherin 13.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GCACTGATTTGCAAAATTTCT	0.393										HNSCC(5;0.00058)			9	27					0	0	0	0	A	187549812	A	A	187549812	4	1	251	1	0	0	0	0	0	1	0	0	5721	1328	46	4	9417	4	FAT1	4	187549812	Nonsense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	35707424	187549812	3604464	19	45928											
TRIO	7204	broad.mit.edu	37	chr5	14488246	14488246	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccggctccttcaccttcccGggggacagcgactccctcca	5	7	9	20	3	1	0	1	0	0	0	5	2	5	1	6	3	1	1	6	3	0	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:14488246G>C	uc003jff.2	+	48	7515	c.7509G>C	c.(7507-7509)CCG>CCC	p.P2503P	TRIO_uc003jfg.2_Intron|TRIO_uc003jfh.1_Silent_p.P2152P	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2503					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCACCTTCCCGGGGGACAGCG	0.721													4	15					0	0	0	0	C	14488246	C	C	14488246	2	2	251	1	0	0	0	0	0	0	0	1	16619	1103	39	3		3	TRIO	5	14488246	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08		14488246	166427014	20	45929											
GPBP1	65056	broad.mit.edu	37	chr5	56546884	56546884	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcctcaagagaatggcaatgCctcagtgatttcccagcaga	12	9	9	11	0	2	3	2	1	0	2	4	4	4	3	3	1	2	2	3	1	3	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:56546884C>T	uc003jrh.3	+	10	2350	c.1076C>T	c.(1075-1077)GCC>GTC	p.A359V	GPBP1_uc010iwg.2_Missense_Mutation_p.A379V|GPBP1_uc003jri.3_Missense_Mutation_p.A188V|GPBP1_uc003jrj.3_Missense_Mutation_p.A351V|GPBP1_uc003jrk.3_Missense_Mutation_p.A366V|GPBP1_uc003jrl.3_RNA	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		AATGGCAATGCCTCAGTGATT	0.393													19	37					0	0	0	0	T	56546884	T	T	56546884	3	4	251	1	0	0	0	0	1	0	0	0	6633	739	26	4	1131	4	GPBP1	5	56546884	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	42058638	56546884	124368376	21	45930											
RASA1	5921	broad.mit.edu	37	chr5	86681171	86681171	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tattagtggctaaatctgtgCagaacttagcaaatcttgtg	12	14	9	6	0	2	1	0	0	2	1	2	1	2	1	0	1	3	3	0	1	7	5			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:86681171C>T	uc003kiw.2	+	22	2930	c.2812C>T	c.(2812-2814)CAG>TAG	p.Q938*	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Nonsense_Mutation_p.Q761*|RASA1_uc011ctv.1_Nonsense_Mutation_p.Q771*|RASA1_uc011ctw.1_Nonsense_Mutation_p.Q772*|RASA1_uc010jaw.2_Nonsense_Mutation_p.Q760*	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	938	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TAAATCTGTGCAGAACTTAGC	0.353													4	24					0	0	0	0	T	86681171	T	T	86681171	4	4	251	1	0	0	0	0	0	1	0	0	13125	711	25	4	2910	4	RASA1	5	86681171	Nonsense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	30134287	86681171	94234089	22	45931											
AFF4	27125	broad.mit.edu	37	chr5	132269973	132269973	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttccatggactcctgtcCgtccatgggccgcacatagg	6	10	12	13	2	0	0	0	0	0	0	4	1	4	1	5	4	0	2	5	4	1	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:132269973C>T	uc003kyd.2	-	3	1192	c.784G>A	c.(784-786)GGA>AGA	p.G262R	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Missense_Mutation_p.G262R|AFF4_uc003kyf.3_Missense_Mutation_p.G262R	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	262	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACTCCTGTCCGTCCATGGGC	0.512													15	61					0	0	0	0	T	132269973	T	T	132269973	3	4	251	1	0	0	0	0	1	0	0	0	359	661	23	1	2783	1	AFF4	5	132269973	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	45588802	132269973	48645287	23	45932											
PCDHB2	56133	broad.mit.edu	37	chr5	140475797	140475797	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccctgcacatcggcagcGtcagcgccacagacagagac	10	3	11	17	4	1	2	1	0	0	2	2	3	1	2	3	1	3	2	3	1	0	0			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:140475797G>A	uc003lil.2	+	1	1561	c.1423G>A	c.(1423-1425)GTC>ATC	p.V475I	PCDHB2_uc003lim.1_Missense_Mutation_p.V136I	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	475	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATCGGCAGCGTCAGCGCCAC	0.667													34	117					0	0	0	0	A	140475797	A	A	140475797	3	1	251	1	0	0	0	0	1	0	0	0	11596	1145	40	1	1425	1	PCDHB2	5	140475797	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	8205824	140475797	40439463	24	45933											
PCDHB13	56123	broad.mit.edu	37	chr5	140595724	140595724	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acctgcctctcccggaggcgGccccgacccaggcccaggcc	5	3	12	21	3	1	0	0	0	1	0	2	2	1	1	8	5	1	0	8	5	0	0			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:140595724G>C	uc003lja.1	+	1	2216	c.2029G>C	c.(2029-2031)GCC>CCC	p.A677P		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	677	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCGGAGGCGGCCCCGACCCA	0.682													36	114					0	0	0	0	C	140595724	C	C	140595724	3	2	251	1	0	0	0	0	1	0	0	0	11592	1203	42	4	2031	4	PCDHB13	5	140595724	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	119927	140595724	40319536	25	45934											
ODZ2	57451	broad.mit.edu	37	chr5	167673804	167673804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaacgtcagtatatatttGagtatgactcctctgaccgc	10	12	8	11	2	2	3	1	3	1	0	3	3	3	3	3	0	1	2	3	0	5	5			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr5:167673804G>A	uc010jjd.2	+	27	5833	c.5833G>A	c.(5833-5835)GAG>AAG	p.E1945K	ODZ2_uc003lzr.3_Missense_Mutation_p.E1715K|ODZ2_uc003lzt.3_Missense_Mutation_p.E1318K|ODZ2_uc010jje.2_Missense_Mutation_p.E1209K	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GTATATATTTGAGTATGACTC	0.512													68	223					0	0	0	0	A	167673804	A	A	167673804	3	1	251	1	0	0	0	0	1	0	0	0	10889	1291	45	2	5939	2	ODZ2	5	167673804	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	27078080	167673804	13241456	26	45935											
HIST1H4F	8361	broad.mit.edu	37	chr6	26240713	26240713	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcgccaagcgccatcgCaaagtgctgcgtgacaacat	11	5	13	12	4	0	1	0	1	0	0	1	2	0	2	2	2	4	2	2	2	3	0			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr6:26240713C>T	uc003nhe.1	+	1	60	c.60C>T	c.(58-60)CGC>CGT	p.R20R		NM_003540	NP_003531	P62805	H4_HUMAN	histone cluster 1, H4f	20					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				AGCGCCATCGCAAAGTGCTGC	0.537													5	18					0	0	0	0	T	26240713	T	T	26240713	2	4	251	1	0	0	0	0	0	0	0	1	7209	697	25	4		4	HIST1H4F	6	26240713	Silent	SNP	C	TCGA-CV-7413-01A-11D-2078-08		26240713	144874354	27	45936											
HIST1H1B	3009	broad.mit.edu	37	chr6	27834874	27834874	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctttttcgcccctgcaGccttcttggccttcttaggc	2	15	8	16	1	2	0	0	0	2	0	3	0	2	0	5	2	3	1	5	2	1	6			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr6:27834874G>T	uc003njx.2	-	1	486	c.434C>A	c.(433-435)GCT>GAT	p.A145D		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	145					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CGCCCCTGCAGCCTTCTTGGC	0.617													41	192					9.84934e-19	1.14552e-18	1	0	T	27834874	T	T	27834874	3	4	251	1	0	0	0	0	1	0	0	0	7162	971	34	4	250	4	HIST1H1B	6	27834874	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	1594161	27834874	143280193	28	45937											
TCTE1	202500	broad.mit.edu	37	chr6	44254022	44254022	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcaggtcgaggatcacCgcagggtctgtggtgcctgg	6	7	18	10	2	2	0	1	0	1	0	3	2	2	1	2	6	2	3	2	6	0	0			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr6:44254022C>T	uc003oxi.2	-	3	681	c.525G>A	c.(523-525)GCG>GCA	p.A175A	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	175										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CGAGGATCACCGCAGGGTCTG	0.652													20	41					0	0	0	0	T	44254022	T	T	44254022	2	4	251	1	0	0	0	0	0	0	0	1	15783	639	23	1		1	TCTE1	6	44254022	Silent	SNP	C	TCGA-CV-7413-01A-11D-2078-08	16419148	44254022	126861045	29	45938											
OCM	654231	broad.mit.edu	37	chr7	5920406	5920406	+	5'Flank	DEL	T	-	-																															tcttaatttaaaaaaaaaaaTaatctagacacacatacagt																								rs10235465		TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr7:5920406delT	uc003spe.3	+							NM_001097622	NP_001091091	P0CE72	ONCO_HUMAN	oncomodulin								calcium ion binding				0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		aaaaaaaaaaTAATCTAGACA	0.229													---	---	---								-	5920406	-	-	5920406	6	5	251	0	1	1	0	1	0	0	0	0	10875	1421	49	0		0	OCM	7	5920406	5'Flank	DEL	T	TCGA-CV-7413-01A-11D-2078-08		5920406	153218257	30	45939											
GRM8	2918	broad.mit.edu	37	chr7	126746580	126746580	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgagatctgggtgaaggcctCcacaccgctctcaccatagt	9	8	10	14	2	2	2	1	1	2	1	4	3	3	2	4	2	0	1	4	2	2	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr7:126746580C>T	uc003vlr.2	-	2	1008	c.697G>A	c.(697-699)GAG>AAG	p.E233K	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.E233K|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_5'UTR	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	233	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GTGAAGGCCTCCACACCGCTC	0.498										HNSCC(24;0.065)			7	20					0	0	0	0	T	126746580	T	T	126746580	3	4	251	1	0	0	0	0	1	0	0	0	6842	864	30	2	2115	2	GRM8	7	126746580	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	120826174	126746580	32392083	31	45940											
TNKS	8658	broad.mit.edu	37	chr8	9605599	9605599	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatgcaacagataagtgggcGtttactcccctccatgaagc	12	9	9	11	1	0	2	0	1	0	1	2	2	2	2	3	1	4	2	3	1	5	3	rs35491087	byFrequency	TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:9605599G>A	uc003wss.2	+	18	2714	c.2709G>A	c.(2707-2709)GCG>GCA	p.A903A	TNKS_uc011kww.1_Silent_p.A666A|TNKS_uc010lrt.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	903	ANK 15.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		ATAAGTGGGCGTTTACTCCCC	0.473													8	31					0	0	0	0	A	9605599	A	A	9605599	2	1	251	1	0	0	0	0	0	0	0	1	16385	1132	40	1		1	TNKS	8	9605599	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08		9605599	136758423	32	45941											
HR	55806	broad.mit.edu	37	chr8	21976769	21976769	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacacagaggttcttggtcCccaggtgtccccggtgcggg	5	8	14	14	2	1	1	0	0	1	1	3	1	3	1	5	5	1	1	5	5	0	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:21976769C>T	uc003xas.2	-	15	3670	c.3005G>A	c.(3004-3006)GGG>GAG	p.G1002E	HR_uc003xat.2_Missense_Mutation_p.G1002E	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	1002	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GTTCTTGGTCCCCAGGTGTCC	0.502													6	34					0	0	0	0	T	21976769	T	T	21976769	3	4	251	1	0	0	0	0	1	0	0	0	7386	623	22	4	584	4	HR	8	21976769	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	12371170	21976769	124387253	33	45942											
ADAM28	10863	broad.mit.edu	37	chr8	24209561	24209561	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcaatgagcccccagcctCttttgtgagttagcaacttc	9	11	9	12	0	1	2	0	2	1	0	2	2	1	2	3	1	4	3	3	1	3	4			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:24209561C>G	uc003xdy.2	+	21	2323	c.2240C>G	c.(2239-2241)TCT>TGT	p.S747C	ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Missense_Mutation_p.S434C	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	747	Cytoplasmic (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CCCCCAGCCTCTTTTGTGAGT	0.408													9	58					0	0	0	0	G	24209561	G	G	24209561	3	3	251	1	0	0	0	0	1	0	0	0	246	913	32	2	2378	2	ADAM28	8	24209561	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	2232792	24209561	122154461	34	45943											
RBM12B	389677	broad.mit.edu	37	chr8	94746535	94746535	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctgaaatcctcctctggggGccgcctgaagtcatcctcgg	6	9	11	15	2	2	2	1	2	1	0	6	2	5	2	6	3	0	0	6	3	2	0			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:94746535G>A	uc003yfz.2	-	3	2297	c.2104C>T	c.(2104-2106)CCC>TCC	p.P702S		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	702							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TCCTCTGGGGGCCGCCTGAAG	0.642													34	124					0	0	0	0	A	94746535	A	A	94746535	3	1	251	1	0	0	0	0	1	0	0	0	13179	1203	42	4	905	4	RBM12B	8	94746535	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	70536974	94746535	51617487	35	45944											
KCNQ3	3786	broad.mit.edu	37	chr8	133141591	133141591	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggcatggagccgctgggcGtgaaggggtccgtgtctgtg	5	8	20	8	3	1	1	0	1	1	0	2	3	2	2	2	5	1	2	2	5	1	0			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:133141591G>A	uc003ytj.2	-	15	2762	c.2537C>T	c.(2536-2538)ACG>ATG	p.T846M	KCNQ3_uc010mdt.2_Missense_Mutation_p.T834M|uc003yti.2_5'Flank	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	846					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GCCGCTGGGCGTGAAGGGGTC	0.572													8	34					0	0	0	0	A	133141591	A	A	133141591	3	1	251	1	0	0	0	0	1	0	0	0	8123	1145	40	1	85	1	KCNQ3	8	133141591	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	38395056	133141591	13222431	36	45945											
OPLAH	26873	broad.mit.edu	37	chr8	145107418	145107418	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acgcgctgcgacgtgagcacGttgccgcccaccaccgccgc	6	4	12	19	8	0	1	0	1	0	0	0	2	0	1	5	0	3	3	5	0	0	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr8:145107418G>A	uc003zar.3	-	23	3319	c.3237C>T	c.(3235-3237)AAC>AAT	p.N1079N		NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1079							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	ACGTGAGCACGTTGCCGCCCA	0.771													3	7					0	0	0	0	A	145107418	A	A	145107418	2	1	251	1	0	0	0	0	0	0	0	1	10930	1136	40	1		1	OPLAH	8	145107418	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08	11965827	145107418	1256604	37	45946											
DOCK8	81704	broad.mit.edu	37	chr9	382632	382632	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcagtaacccagacctcGcggggacacactccgcagca	11	3	11	16	3	0	1	0	0	0	1	2	2	1	2	3	2	3	5	3	2	1	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:382632G>A	uc003zgf.2	+	22	2837	c.2725G>A	c.(2725-2727)GCG>ACG	p.A909T	DOCK8_uc010mgu.2_Missense_Mutation_p.A211T|DOCK8_uc010mgv.2_Missense_Mutation_p.A841T|DOCK8_uc010mgw.1_Missense_Mutation_p.A211T|DOCK8_uc003zgk.2_Missense_Mutation_p.A367T	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	909					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CCCAGACCTCGCGGGGACACA	0.542													7	30					0	0	0	0	A	382632	A	A	382632	3	1	251	1	0	0	0	0	1	0	0	0	4715	1087	38	1	2811	1	DOCK8	9	382632	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08		382632	140830799	38	45947											
CDKN2A	1029	broad.mit.edu	37	chr9	21971028	21971028	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggtccacgggcagacggccCcaggcatcgcgcacgtccag	8	3	14	16	5	0	1	0	0	0	1	3	1	2	1	4	4	0	3	4	4	0	0	rs121913389		TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:21971028C>T	uc003zpk.2	-	2	542	c.330G>A	c.(328-330)TGG>TGA	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.G166R	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGACGGCCCCAGGCATCGC	0.736		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	17					0	0	0	0	T	21971028	T	T	21971028	4	4	251	1	0	0	0	0	0	1	0	0	3176	624	22	4	148	4	CDKN2A	9	21971028	Nonsense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	21588396	21971028	119242403	39	45948											
CCDC107	203260	broad.mit.edu	37	chr9	35658653	35658653	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcaacgcgagcggacccggGccgggtcgctgcctctgggg	5	5	17	14	6	2	0	1	0	1	0	3	2	2	1	3	5	3	1	3	5	1	0			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:35658653G>A	uc011lox.1	+	2	253	c.187G>A	c.(187-189)GCC>ACC	p.A63T	RMRP_uc003zxh.1_5'Flank|CCDC107_uc010mkx.1_Missense_Mutation_p.A63T|CCDC107_uc011loy.1_Missense_Mutation_p.A63T|CCDC107_uc003zxj.2_Missense_Mutation_p.A63T|CCDC107_uc003zxk.2_Missense_Mutation_p.A63T	NM_174923	NP_777583	Q8WV48	CC107_HUMAN	coiled-coil domain containing 107 precursor	63						integral to membrane					0	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCGGACCCGGGCCGGGTCGCT	0.716													8	13					0	0	0	0	A	35658653	A	A	35658653	3	1	251	1	0	0	0	0	1	0	0	0	2754	1203	42	4	193	4	CCDC107	9	35658653	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	13687625	35658653	105554778	40	45949											
ZNF189	7743	broad.mit.edu	37	chr9	104170879	104170879	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttggaaatcacaccttattGagcatcaaagaactcacact	15	10	6	10	0	3	2	3	1	0	1	3	3	3	3	1	1	2	2	1	1	4	3			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:104170879G>A	uc004bbh.1	+	3	1105	c.829G>A	c.(829-831)GAG>AAG	p.E277K	ZNF189_uc004bbg.1_Missense_Mutation_p.E235K|ZNF189_uc004bbi.1_Missense_Mutation_p.E263K|ZNF189_uc011lvk.1_Missense_Mutation_p.E262K	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	277	C2H2-type 5.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				ACACCTTATTGAGCATCAAAG	0.393													55	106					0	0	0	0	A	104170879	A	A	104170879	3	1	251	1	0	0	0	0	1	0	0	0	17821	1291	45	2	839	2	ZNF189	9	104170879	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	68512226	104170879	37042552	41	45950											
PSMB7	5695	broad.mit.edu	37	chr9	127177670	127177670	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agttatcaaaagagaagcctCcaactggtggagcatacacc	15	7	9	10	0	1	1	1	0	0	1	2	3	2	2	3	2	4	2	3	2	6	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:127177670C>T	uc004boj.2	-	1	52	c.35G>A	c.(34-36)GGA>GAA	p.G12E	PSMB7_uc010mwm.2_Missense_Mutation_p.G12E	NM_002799	NP_002790	Q99436	PSB7_HUMAN	proteasome beta 7 subunit proprotein	12					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0						AGAGAAGCCTCCAACTGGTGG	0.607											OREG0019476	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	13					0	0	0	0	T	127177670	T	T	127177670	3	4	251	1	0	0	0	0	1	0	0	0	12744	855	30	2	830	2	PSMB7	9	127177670	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	23006791	127177670	14035761	42	45951											
C9orf167	54863	broad.mit.edu	37	chr9	140174120	140174120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgcgccccgacggcttcCgcagtgccgaggccgcagcg	4	4	14	19	7	0	0	0	0	0	0	1	2	1	0	6	2	3	3	6	2	0	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr9:140174120C>T	uc004cmn.2	+	2	1096	c.979C>T	c.(979-981)CGC>TGC	p.R327C	C9orf167_uc011mew.1_5'Flank	NM_017723	NP_060193	Q9NXH8	CI167_HUMAN	hypothetical protein LOC54863	327					chaperone mediated protein folding requiring cofactor	integral to membrane	ATP binding|nucleoside-triphosphatase activity			pancreas(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.07e-05)|Epithelial(140;0.000728)		CGACGGCTTCCGCAGTGCCGA	0.741													7	2					0	0	0	0	T	140174120	T	T	140174120	3	4	251	1	0	0	0	0	1	0	0	0	2480	652	23	1	981	1	C9orf167	9	140174120	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	12996450	140174120	1039311	43	45952											
CELF2	10659	broad.mit.edu	37	chr10	11370983	11370983	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaacgcttgaaggtgcagctGaagcgttccaaaaacgacag	15	6	11	9	3	0	2	0	2	0	0	1	3	1	2	1	1	5	4	1	1	5	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr10:11370983G>A	uc001iki.3	+	13	1586	c.1494G>A	c.(1492-1494)CTG>CTA	p.L498L	CELF2_uc010qbj.1_Silent_p.L504L|CELF2_uc001ikk.2_Silent_p.L523L|CELF2_uc001ikl.3_Silent_p.L511L|CELF2_uc010qbl.1_Silent_p.L474L|CELF2_uc010qbm.1_Silent_p.L270L|CELF2_uc001iko.3_Silent_p.L478L|CELF2_uc001ikp.3_Silent_p.L480L|CELF2_uc010qbn.1_Silent_p.L486L|CELF2_uc010qbo.1_Silent_p.L393L|CELF2_uc010qbp.1_Silent_p.L270L	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	498	RRM 3.|Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						AGGTGCAGCTGAAGCGTTCCA	0.488													12	59					0	0	0	0	A	11370983	A	A	11370983	2	1	251	1	0	0	0	0	0	0	0	1	3231	1277	45	2		2	CELF2	10	11370983	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08		11370983	124163764	44	45953											
SEC61A2	55176	broad.mit.edu	37	chr10	12191922	12191922	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatgtatggggaccctgcaGaaatgggtgccggaatctgt	9	9	16	7	1	1	1	0	0	1	1	1	4	1	4	2	5	2	2	2	5	3	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr10:12191922G>A	uc001ile.2	+	6	571	c.424G>A	c.(424-426)GAA>AAA	p.E142K	SEC61A2_uc010qbq.1_Missense_Mutation_p.E120K|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Missense_Mutation_p.E142K	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	142	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				GGACCCTGCAGAAATGGGTGC	0.428													15	60					0	0	0	0	A	12191922	A	A	12191922	3	1	251	1	0	0	0	0	1	0	0	0	14066	943	33	2	446	2	SEC61A2	10	12191922	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	820939	12191922	123342825	45	45954											
HPS6	79803	broad.mit.edu	37	chr10	103826339	103826339	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggaggatgaggaagagctgGagacccgagggaatcttcgt	11	7	17	6	2	1	3	0	1	1	2	2	9	1	7	1	5	1	1	1	5	2	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr10:103826339G>A	uc001kuj.2	+	1	1193	c.1108G>A	c.(1108-1110)GAG>AAG	p.E370K		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	370						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		GGAAGAGCTGGAGACCCGAGG	0.582									Hermansky-Pudlak_syndrome				12	47					0	0	0	0	A	103826339	A	A	103826339	3	1	251	1	0	0	0	0	1	0	0	0	7382	1175	41	2	1110	2	HPS6	10	103826339	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	91634417	103826339	31708408	46	45955											
SORCS3	22986	broad.mit.edu	37	chr10	106899230	106899230	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcagataaagctgcctaagTactcgttgccaaaggtactg	12	10	9	10	1	1	1	1	0	0	1	2	1	1	1	2	1	5	4	2	1	6	5			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr10:106899230T>C	uc001kyi.1	+	8	1515	c.1288T>C	c.(1288-1290)TAC>CAC	p.Y430H		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	430	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GCTGCCTAAGTACTCGTTGCC	0.512													14	53					0	0	0	0	C	106899230	C	C	106899230	3	2	251	1	0	0	0	0	1	0	0	0	14996	1638	57	5	1318	5	SORCS3	10	106899230	Missense_Mutation	SNP	T	TCGA-CV-7413-01A-11D-2078-08	3072891	106899230	28635517	47	45956											
SIRT3	23410	broad.mit.edu	37	chr11	219014	219014	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggaactgagctccgcacggCctcggtcaagctggcaaaag	10	5	14	12	3	1	1	1	1	0	0	3	2	2	2	2	4	3	4	2	4	4	0			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr11:219014C>T	uc001lok.3	-	6	1031	c.997G>A	c.(997-999)GCC>ACC	p.A333T	SIRT3_uc001loj.3_Missense_Mutation_p.A191T|SIRT3_uc010qvm.1_Missense_Mutation_p.A269T|SIRT3_uc010qvn.1_Missense_Mutation_p.A252T|SIRT3_uc010qvo.1_Missense_Mutation_p.A333T|SIRT3_uc010qvp.1_Missense_Mutation_p.A279T|SIRT3_uc010qvq.1_Missense_Mutation_p.A191T	NM_012239	NP_036371	Q9NTG7	SIRT3_HUMAN	sirtuin 3 isoform a	333	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			urinary_tract(1)	1		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		CTCCGCACGGCCTCGGTCAAG	0.612													8	13					0	0	0	0	T	219014	T	T	219014	3	4	251	1	0	0	0	0	1	0	0	0	14404	739	26	4	210	4	SIRT3	11	219014	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08		219014	134787502	48	45957											
ACSM4	341392	broad.mit.edu	37	chr12	7469847	7469847	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcccagcactctcagagcagCctcggcattgggttcaccct	7	8	10	16	1	2	1	2	0	1	1	4	1	2	1	3	2	3	4	3	2	0	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:7469847C>T	uc001qsx.1	+	4	735	c.735C>T	c.(733-735)AGC>AGT	p.S245S		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	245					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						CTCAGAGCAGCCTCGGCATTG	0.393													4	4					0	0	0	0	T	7469847	T	T	7469847	2	4	251	1	0	0	0	0	0	0	0	1	186	738	26	4		4	ACSM4	12	7469847	Silent	SNP	C	TCGA-CV-7413-01A-11D-2078-08		7469847	126382048	49	45958											
CLEC9A	283420	broad.mit.edu	37	chr12	10213747	10213747	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttgcaggtgtccaccattgCgatgcagcagcaagaaaaac	13	7	11	10	1	0	1	0	0	0	1	1	2	1	1	2	1	6	5	2	1	3	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:10213747C>T	uc001qxa.2	+	6	807	c.194C>T	c.(193-195)GCG>GTG	p.A65V		NM_207345	NP_997228	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	65	Extracellular (Potential).				positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1						TCCACCATTGCGATGCAGCAG	0.403													5	16					0	0	0	0	T	10213747	T	T	10213747	3	4	251	1	0	0	0	0	1	0	0	0	3537	768	27	1	204	1	CLEC9A	12	10213747	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	2743900	10213747	123638148	50	45959											
APOLD1	81575	broad.mit.edu	37	chr12	12940351	12940353	+	In_Frame_Del	DEL	TCT	-	-																															caattctgtctacttcatcgTcttctttggctcacgtggct																										TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:12940351_12940353delTCT	uc001rau.3	+	2	689_691	c.605_607delTCT	c.(604-609)GTCTTC>GTC	p.F204del	DDX47_uc001rav.2_Intron|APOLD1_uc001raw.3_In_Frame_Del_p.F173del	NM_001130415	NP_001123887	Q96LR9	APLD1_HUMAN	apolipoprotein L domain containing 1 isoform 1	204	Helical; (Potential).				angiogenesis|cell differentiation|lipid transport|lipoprotein metabolic process	extracellular region|integral to membrane|plasma membrane	lipid binding			ovary(1)	1		Prostate(47;0.0632)		BRCA - Breast invasive adenocarcinoma(232;0.0338)|GBM - Glioblastoma multiforme(207;0.149)		TACTTCATCGTCTTCTTTGGCTC	0.616													---	---	---								-	12940353	-	-	12940351	7	5	251	1	0	1	0	1	0	0	0	0	811	1667	58	0	618	0	APOLD1	12	12940351	In_Frame_Del	DEL	TCT	TCGA-CV-7413-01A-11D-2078-08	2726604	12940351	120911544	51	45960											
KRT79	338785	broad.mit.edu	37	chr12	53217762	53217762	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtgtcccgcaggttgtccCcatgcttcccagcagtcacc	5	10	10	16	1	1	0	1	0	0	0	4	0	4	0	5	2	2	4	5	2	0	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:53217762C>T	uc001sbb.2	-	6	1088	c.1055G>A	c.(1054-1056)GGG>GAG	p.G352E	KRT79_uc001sba.2_Missense_Mutation_p.G123E	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	352	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						CAGGTTGTCCCCATGCTTCCC	0.612													10	33					0	0	0	0	T	53217762	T	T	53217762	3	4	251	1	0	0	0	0	1	0	0	0	8531	623	22	4	568	4	KRT79	12	53217762	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	40277411	53217762	80634133	52	45961											
OR6C4	341418	broad.mit.edu	37	chr12	55945682	55945682	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacattatcaggactattctGaggatcccttctgcccagca	10	12	7	12	0	3	1	1	1	2	0	4	3	4	3	2	2	3	1	2	2	3	5			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:55945682G>T	uc010spp.1	+	1	672	c.672G>T	c.(670-672)CTG>CTT	p.L224L		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGACTATTCTGAGGATCCCTT	0.468													13	64					4.36969e-10	4.92165e-10	1	0	T	55945682	T	T	55945682	2	4	251	1	0	0	0	0	0	0	0	1	11247	1277	45	2		2	OR6C4	12	55945682	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08	2727920	55945682	77906213	53	45962											
OAS2	4939	broad.mit.edu	37	chr12	113444282	113444282	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggctcattgatctgtataaAtcctcggacctcccgggagg	8	10	12	11	2	2	1	1	1	1	0	5	3	4	3	3	4	0	2	3	4	3	3			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:113444282A>G	uc001tuj.2	+	8	1673	c.1533A>G	c.(1531-1533)AAA>AAG	p.K511K	OAS2_uc001tui.1_Silent_p.K511K	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	511	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						ATCTGTATAAATCCTCGGACC	0.512													26	69					0	0	0	0	G	113444282	G	G	113444282	2	3	251	1	0	0	0	0	0	0	0	1	10854	98	4	5		5	OAS2	12	113444282	Silent	SNP	A	TCGA-CV-7413-01A-11D-2078-08	57498600	113444282	20407613	54	45963											
RIMBP2	23504	broad.mit.edu	37	chr12	130892282	130892282	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctggtacctcgacatcgaCgttgggcgagctttctctgg	5	11	14	11	4	1	0	0	0	1	0	4	3	1	0	1	4	2	4	1	4	1	3	rs142858015	byFrequency	TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr12:130892282C>T	uc001uil.2	-	16	3078	c.2914G>A	c.(2914-2916)GTC>ATC	p.V972I		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	972	SH3 3.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCGACATCGACGTTGGGCGAG	0.567													52	186					0	0	0	0	T	130892282	T	T	130892282	3	4	251	1	0	0	0	0	1	0	0	0	13428	536	19	1	260	1	RIMBP2	12	130892282	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	17448000	130892282	2959613	55	45964											
C14orf174	161394	broad.mit.edu	37	chr14	77844099	77844099	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtaaagtcggaaacatccaGagagatgggagagtttttca	14	9	13	5	1	1	3	1	0	0	3	3	6	2	4	1	3	1	2	1	3	3	3			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr14:77844099G>A	uc001xtq.1	+	1	338	c.338G>A	c.(337-339)AGA>AAA	p.R113K	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	113											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		GAAACATCCAGAGAGATGGGA	0.493													19	125					0	0	0	0	A	77844099	A	A	77844099	3	1	251	1	0	0	0	0	1	0	0	0	1765	942	33	2	340	2	C14orf174	14	77844099	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08		77844099	29505441	56	45965											
ACSBG1	23205	broad.mit.edu	37	chr15	78526821	78526821	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccccgtgtgggcagccgtatCcagctccagaattgcgtggc	6	8	13	14	3	0	1	0	0	0	1	2	1	2	1	5	2	3	3	5	2	2	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr15:78526821C>T	uc002bdh.2	-	1	79	c.23G>A	c.(22-24)GGA>GAA	p.G8E	ACSBG1_uc010umw.1_Missense_Mutation_p.G8E|ACSBG1_uc010umx.1_5'UTR|ACSBG1_uc010umy.1_5'UTR	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	8					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						GCAGCCGTATCCAGCTCCAGA	0.597													38	195					0	0	0	0	T	78526821	T	T	78526821	3	4	251	1	0	0	0	0	1	0	0	0	173	855	30	2	2207	2	ACSBG1	15	78526821	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08		78526821	24004571	57	45966											
AGBL1	123624	broad.mit.edu	37	chr15	87531246	87531246	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catccaatttcctgccaaagCatatttggtttgcttaccac	10	14	5	12	0	0	0	0	0	0	0	2	0	2	0	4	1	4	3	4	1	4	5			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr15:87531246C>G	uc002blz.1	+	23	3192	c.3112C>G	c.(3112-3114)CAT>GAT	p.H1038D		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	1038					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						cctgccaaagcatatttggtt	0													43	104					0	0	0	0	G	87531246	G	G	87531246	3	3	251	1	0	0	0	0	1	0	0	0	375	710	25	4	3198	4	AGBL1	15	87531246	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	9004425	87531246	15000146	58	45967											
ADAMTS17	170691	broad.mit.edu	37	chr15	100657103	100657103	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttcttggggctcagccggtCgtgtgcctggcactgctggt	2	12	15	12	2	2	0	1	0	1	0	3	0	2	0	2	5	3	3	2	5	0	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr15:100657103C>T	uc002bvv.1	-	13	1916	c.1837G>A	c.(1837-1839)GAC>AAC	p.D613N	ADAMTS17_uc002bvx.1_Missense_Mutation_p.D370N	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	613	Cys-rich.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CTCAGCCGGTCGTGTGCCTGG	0.627													22	38					0	0	0	0	T	100657103	T	T	100657103	3	4	251	1	0	0	0	0	1	0	0	0	262	884	31	1	1490	1	ADAMTS17	15	100657103	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	13125857	100657103	1874289	59	45968											
PDXDC1	23042	broad.mit.edu	37	chr16	15128328	15128328	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcagggggtgttgcggcaGatccctgtagtgggctccgt	4	11	17	9	2	0	1	0	0	0	1	2	1	2	1	2	4	2	5	2	4	1	3			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr16:15128328G>A	uc002dda.3	+	21	2144	c.1920G>A	c.(1918-1920)CAG>CAA	p.Q640Q	PDXDC1_uc010uzl.1_Silent_p.Q625Q|PDXDC1_uc010uzm.1_Silent_p.Q549Q|PDXDC1_uc002ddb.3_Silent_p.Q613Q|PDXDC1_uc010uzn.1_Silent_p.Q612Q|PDXDC1_uc002ddc.2_Intron	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	640					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	TGTTGCGGCAGATCCCTGTAG	0.602													30	105					0	0	0	0	A	15128328	A	A	15128328	2	1	251	1	0	0	0	0	0	0	0	1	11750	933	33	2		2	PDXDC1	16	15128328	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08		15128328	75226425	60	45969											
TAOK2	9344	broad.mit.edu	37	chr16	29994159	29994159	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacctgcagtaccgcaagatGaagaagatcctgttccaaga	15	7	9	10	1	0	5	0	1	0	4	2	5	2	5	4	0	3	4	4	0	6	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr16:29994159G>A	uc002dva.1	+	11	1719	c.936G>A	c.(934-936)ATG>ATA	p.M312I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.M312I|TAOK2_uc002dvc.1_Missense_Mutation_p.M312I|TAOK2_uc010bzm.1_Missense_Mutation_p.M312I|TAOK2_uc002dvd.1_Missense_Mutation_p.M139I	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	312					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						ACCGCAAGATGAAGAAGATCC	0.607													20	61					0	0	0	0	A	29994159	A	A	29994159	3	1	251	1	0	0	0	0	1	0	0	0	15614	1290	45	2	974	2	TAOK2	16	29994159	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	14865831	29994159	60360594	61	45970											
THAP11	57215	broad.mit.edu	37	chr16	67876720	67876720	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgcgcggcgtcaatgagcGcaaagtagcgcgcagacccg	9	4	15	13	7	1	2	1	1	0	1	1	2	1	2	1	1	3	4	1	1	3	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr16:67876720G>C	uc002euo.2	+	1	508	c.263G>C	c.(262-264)CGC>CCC	p.R88P	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		GTCAATGAGCGCAAAGTAGCG	0.408													7	17					0	0	0	0	C	67876720	C	C	67876720	3	2	251	1	0	0	0	0	1	0	0	0	15909	1087	38	3	265	3	THAP11	16	67876720	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	37882561	67876720	22478033	62	45971											
TP53	7157	broad.mit.edu	37	chr17	7579374	7579374	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagacggaaaccgtagctgcCctggtaggttttctgggaag	9	9	14	9	2	1	1	0	0	1	1	1	3	1	3	2	4	3	4	2	4	4	4			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr17:7579374C>A	uc002gim.2	-	4	507	c.313G>T	c.(313-315)GGC>TGC	p.G105C	TP53_uc002gig.1_Missense_Mutation_p.G105C|TP53_uc002gih.2_Missense_Mutation_p.G105C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.G105C|TP53_uc010cni.1_Missense_Mutation_p.G105C|TP53_uc002gij.2_Missense_Mutation_p.G105C|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.G66C|TP53_uc010cnk.1_Missense_Mutation_p.G120C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	105	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		G -> D (in sporadic cancers; somatic mutation).|G -> S (in a sporadic cancer; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G105C(5)|p.G105fs*18(3)|p.G59fs*23(3)|p.G105R(2)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G105A(1)|p.G105S(1)|p.G105V(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.G105G(1)|p.G105D(1)|p.Y103_L111>L(1)|p.Y103fs*15(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGTAGCTGCCCTGGTAGGTT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	38					3.99451e-17	4.59583e-17	1	0	A	7579374	A	A	7579374	3	1	251	1	0	0	0	0	1	0	0	0	16448	623	22	4	989	4	TP53	17	7579374	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08		7579374	73615836	63	45972											
RAI1	10743	broad.mit.edu	37	chr17	17696924	17696924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtccttccccacctcctccaCctactcctcctctgtccagg	4	11	4	22	0	1	0	0	0	1	0	8	0	8	0	10	1	1	0	10	1	1	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr17:17696924C>T	uc002grm.2	+	3	1131	c.662C>T	c.(661-663)ACC>ATC	p.T221I	RAI1_uc002grn.1_Missense_Mutation_p.T221I	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	221	Gln-rich.					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		ACCTCCTCCACCTACTCCTCC	0.627													36	68					0	0	0	0	T	17696924	T	T	17696924	3	4	251	1	0	0	0	0	1	0	0	0	13072	507	18	4	664	4	RAI1	17	17696924	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08	10117550	17696924	63498286	64	45973											
ARHGAP27	201176	broad.mit.edu	37	chr17	43472974	43472974	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacgctctgcaccgacatgcGgttctgctcgccgtgctcga	5	9	11	16	6	2	0	0	0	2	0	4	2	2	0	2	1	4	5	2	1	0	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr17:43472974G>A	uc002iix.2	-	17	1944	c.1495C>T	c.(1495-1497)CGC>TGC	p.R499C	ARHGAP27_uc010dak.2_Missense_Mutation_p.R472C	NM_199282	NP_954976	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27 isoform a	840	Rho-GAP.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)					ACCGACATGCGGTTCTGCTCG	0.667													3	9					0	0	0	0	A	43472974	A	A	43472974	3	1	251	1	0	0	0	0	1	0	0	0	876	1116	39	1	155	1	ARHGAP27	17	43472974	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	25776050	43472974	37722236	65	45974											
ANKRD30B	374860	broad.mit.edu	37	chr18	14782606	14782606	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtaatggagataaatagagaAgtagaaggtaagaacaactt	20	8	11	2	0	0	4	0	0	0	4	0	6	0	4	0	2	2	3	0	2	10	6			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr18:14782606A>C	uc010dlo.2	+	12	1743	c.1563A>C	c.(1561-1563)GAA>GAC	p.E521D	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	521										ovary(1)|skin(1)	2						TAAATAGAGAAGTAGAAGGTA	0.313													6	13					0	0	0	0	C	14782606	C	C	14782606	3	2	251	1	0	0	0	0	1	0	0	0	659	69	3	5	1609	5	ANKRD30B	18	14782606	Missense_Mutation	SNP	A	TCGA-CV-7413-01A-11D-2078-08		14782606	63294642	66	45975											
LAMA3	3909	broad.mit.edu	37	chr18	21444832	21444832	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttcttctggaaaagaagccGgatgtacagctcactgtagg	11	10	12	8	1	3	1	1	0	2	1	3	3	3	3	1	3	3	4	1	3	5	4			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr18:21444832G>A	uc002kuq.2	+	36	4754	c.4668G>A	c.(4666-4668)CCG>CCA	p.P1556P	LAMA3_uc002kur.2_Silent_p.P1556P	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1556	Laminin IV type A.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAAGAAGCCGGATGTACAGC	0.448													3	51					0	0	0	0	A	21444832	A	A	21444832	2	1	251	1	0	0	0	0	0	0	0	1	8647	1103	39	1		1	LAMA3	18	21444832	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08	6662226	21444832	56632416	67	45976											
ACAA2	10449	broad.mit.edu	37	chr18	47340565	47340565	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tttccttatatgatcaggtcCcattgcgggcggcgccgctt	5	13	11	12	4	1	1	1	1	0	0	3	1	3	1	3	3	1	1	3	3	2	5			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr18:47340565C>T	uc002ldw.3	-						ACAA2_uc002ldx.3_5'Flank|SCARNA17_uc002ldy.1_RNA	NM_006111	NP_006102	P42765	THIM_HUMAN	acetyl-coenzyme A acyltransferase 2						anti-apoptosis|cholesterol biosynthetic process		acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1						TGATCAGGTCCCATTGCGGGC	0.617													14	89					0	0	0	0	T	47340565	T	T	47340565	1	4	251	0	1	0	0	0	0	0	0	0	105	638	22	4		4	ACAA2	18	47340565	5'Flank	SNP	C	TCGA-CV-7413-01A-11D-2078-08	25895733	47340565	30736683	68	45977											
DSEL	92126	broad.mit.edu	37	chr18	65179933	65179933	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggactattgccatgatgaTcaaaccaaaacattttgtaa	15	12	7	7	0	1	2	1	2	0	0	1	3	1	3	2	1	3	1	2	1	5	5			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr18:65179933T>A	uc002lke.1	-	2	3167	c.1943A>T	c.(1942-1944)GAT>GTT	p.D648V		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	638						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				GCCATGATGATCAAACCAAAA	0.348													12	44					0	0	0	0	A	65179933	A	A	65179933	3	1	251	1	0	0	0	0	1	0	0	0	4797	1435	50	5	1729	5	DSEL	18	65179933	Missense_Mutation	SNP	T	TCGA-CV-7413-01A-11D-2078-08	17839368	65179933	12897315	69	45978											
CARM1	10498	broad.mit.edu	37	chr19	11018790	11018790	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgtgttcagcgagcggaCggaggagtcttctgccgtgc	5	10	16	10	4	4	0	1	0	3	0	4	4	4	3	1	3	4	1	1	3	0	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr19:11018790C>T	uc002mpz.2	+	3	548	c.422C>T	c.(421-423)ACG>ATG	p.T141M	CARM1_uc010dxn.2_RNA	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	141					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						AGCGAGCGGACGGAGGAGTCT	0.637													15	77					0	0	0	0	T	11018790	T	T	11018790	3	4	251	1	0	0	0	0	1	0	0	0	2667	536	19	1	432	1	CARM1	19	11018790	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08		11018790	48110193	70	45979											
KANK2	25959	broad.mit.edu	37	chr19	11280802	11280802	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtggccgtgctcacaggcGcacatgagggccgtggagcc	6	7	16	12	3	1	1	1	1	0	0	1	2	1	2	3	4	2	2	3	4	0	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr19:11280802G>A	uc010dxv.2	-	13	2892	c.2334C>T	c.(2332-2334)TGC>TGT	p.C778C	KANK2_uc002mqm.2_Silent_p.C786C|KANK2_uc002mqo.3_Silent_p.C778C|KANK2_uc002mqp.1_Silent_p.C587C	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	778	ANK 4.										0						GCTCACAGGCGCACATGAGGG	0.637													15	44					0	0	0	0	A	11280802	A	A	11280802	2	1	251	1	0	0	0	0	0	0	0	1	8016	1079	38	1		1	KANK2	19	11280802	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08	262012	11280802	47848181	71	45980											
PAF1	54623	broad.mit.edu	37	chr19	39879970	39879970	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cataacggttgaactcagtgGagatgtactctgtctttcgc	9	13	10	9	2	3	2	1	1	2	1	4	3	3	2	0	2	3	2	0	2	3	4			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr19:39879970G>A	uc002old.2	-	6	588	c.413C>T	c.(412-414)TCC>TTC	p.S138F	PAF1_uc002ole.1_Missense_Mutation_p.S128F|PAF1_uc010xuv.1_RNA|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	138					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GAACTCAGTGGAGATGTACTC	0.517													11	53					0	0	0	0	A	39879970	A	A	39879970	3	1	251	1	0	0	0	0	1	0	0	0	11437	1174	41	2	1218	2	PAF1	19	39879970	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	28599168	39879970	19249013	72	45981											
KIR2DL3	3804	broad.mit.edu	37	chr19	55250985	55250985	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagggggcctggccacatGagggtgagtccttctccaaa	8	8	14	11	0	1	2	0	2	1	0	3	2	2	2	4	4	1	1	4	4	1	1			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr19:55250985G>A	uc002qgv.2	+	2	85	c.67G>A	c.(67-69)GAG>AAG	p.E23K	KIR2DL3_uc002qgx.2_Missense_Mutation_p.E23K|KIR2DL3_uc002qgy.2_Missense_Mutation_p.E23K|KIR2DL3_uc010erw.1_Missense_Mutation_p.E23K|KIR2DL1_uc002qgz.1_5'UTR|KIR2DL3_uc002qha.1_5'Flank	NM_015868	NP_056952	P43628	KI2L3_HUMAN	killer cell immunoglobulin-like receptor, two	23	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	antigen binding|protein binding|receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		CTGGCCACATGAGGGTGAGTC	0.542													19	77					0	0	0	0	A	55250985	A	A	55250985	3	1	251	1	0	0	0	0	1	0	0	0	8356	1291	45	2	73	2	KIR2DL3	19	55250985	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	15371015	55250985	3877998	73	45982											
NLRP7	199713	broad.mit.edu	37	chr19	55450492	55450492	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagacctccttcaggtcggtCacggataagggcttatttgc	9	11	11	10	2	2	1	2	0	0	1	4	2	3	2	2	4	1	1	2	4	3	4			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr19:55450492C>G	uc002qih.3	-	4	1771	c.1695G>C	c.(1693-1695)GTG>GTC	p.V565V	NLRP7_uc002qig.3_Silent_p.V565V|NLRP7_uc002qii.3_Silent_p.V565V|NLRP7_uc010esk.2_Silent_p.V565V|NLRP7_uc010esl.2_Silent_p.V593V	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	565							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TCAGGTCGGTCACGGATAAGG	0.527													21	39					0	0	0	0	G	55450492	G	G	55450492	2	3	251	1	0	0	0	0	0	0	0	1	10536	813	29	2		2	NLRP7	19	55450492	Silent	SNP	C	TCGA-CV-7413-01A-11D-2078-08	199507	55450492	3678491	74	45983											
NFATC2	4773	broad.mit.edu	37	chr20	50140118	50140118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggcgaggctggttcgaggtGacattattggcgaggttctg	6	11	17	7	4	1	1	0	1	1	0	2	4	1	1	0	6	0	3	0	6	1	4			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr20:50140118G>A	uc002xwd.2	-	2	882	c.662C>T	c.(661-663)TCA>TTA	p.S221L	NFATC2_uc002xwc.2_Missense_Mutation_p.S221L|NFATC2_uc010zyv.1_Missense_Mutation_p.S2L|NFATC2_uc010zyw.1_Missense_Mutation_p.S2L|NFATC2_uc010zyx.1_Missense_Mutation_p.S201L|NFATC2_uc010zyy.1_Missense_Mutation_p.S2L|NFATC2_uc010zyz.1_Missense_Mutation_p.S2L|NFATC2_uc002xwe.2_Missense_Mutation_p.S201L	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	221	3 X approximate SP repeats.|2.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GGTTCGAGGTGACATTATTGG	0.652													20	71					0	0	0	0	A	50140118	A	A	50140118	3	1	251	1	0	0	0	0	1	0	0	0	10416	1294	45	2	2199	2	NFATC2	20	50140118	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08		50140118	12885402	75	45984											
KRTAP6-3	337968	broad.mit.edu	37	chr21	31965096	31965096	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctttggctactactattGaggacaccatgggagactct	10	11	10	10	0	1	2	0	1	1	1	1	4	1	3	1	3	3	2	1	3	3	5			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr21:31965096G>A	uc002yom.2	+	1	338	c.332G>A	c.(331-333)TGA>TAA	p.*111*		NM_181605	NP_853636			keratin associated protein 6-3												0						TACTACTATTGAGGACACCAT	0.443													3	11					0	0	0	0	A	31965096	A	A	31965096	2	1	251	1	0	0	0	0	0	0	0	1	8611	1285	45	2		2	KRTAP6-3	21	31965096	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08		31965096	16164799	76	45985											
CECR1	51816	broad.mit.edu	37	chr22	17669265	17669265	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaagaagtaaggcagcttaaCgccatccttggcggggatca	12	7	13	9	2	1	1	1	0	0	1	2	3	2	2	2	4	2	3	2	4	4	3	rs74317375	byFrequency	TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chr22:17669265C>T	uc002zmk.1	-	6	1257	c.1045G>A	c.(1045-1047)GTT>ATT	p.V349I	CECR1_uc010gqu.1_Missense_Mutation_p.V349I|CECR1_uc011agi.1_Missense_Mutation_p.V307I|CECR1_uc002zmj.1_Missense_Mutation_p.V108I	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	349					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				GGCAGCTTAACGCCATCCTTG	0.607													3	51					0	0	0	0	T	17669265	T	T	17669265	3	4	251	1	0	0	0	0	1	0	0	0	3220	536	19	1	506	1	CECR1	22	17669265	Missense_Mutation	SNP	C	TCGA-CV-7413-01A-11D-2078-08		17669265	33635301	77	45986											
NHS	4810	broad.mit.edu	37	chrX	17744146	17744146	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagtgggagcagctccacGtgcccctcgcagacctcaga	8	6	13	14	2	1	2	1	0	0	2	3	4	2	4	4	2	3	3	4	2	0	0			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chrX:17744146G>A	uc004cxx.2	+	6	2195	c.1857G>A	c.(1855-1857)ACG>ACA	p.T619T	NHS_uc011mix.1_Silent_p.T640T|NHS_uc004cxy.2_Silent_p.T463T|NHS_uc004cxz.2_Silent_p.T442T|NHS_uc004cya.2_Silent_p.T342T	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	619						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					GCAGCTCCACGTGCCCCTCGC	0.582													26	100					0	0	0	0	A	17744146	A	A	17744146	2	1	251	1	0	0	0	0	0	0	0	1	10465	1132	40	1		1	NHS	23	17744146	Silent	SNP	G	TCGA-CV-7413-01A-11D-2078-08		17744146	137526414	78	45987											
ZCCHC13	389874	broad.mit.edu	37	chrX	73524270	73524270	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtggtgagtccggtcgtaatGctaagaactgtgtccttctc	7	13	12	9	2	1	2	0	1	1	1	5	2	3	2	2	2	2	2	2	2	3	3			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chrX:73524270G>T	uc004ebs.3	+	1	246	c.169G>T	c.(169-171)GCT>TCT	p.A57S		NM_203303	NP_976048	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	57	CCHC-type 2; degenerate.						nucleic acid binding|zinc ion binding				0						CGGTCGTAATGCTAAGAACTG	0.527													6	27					0.00116845	0.00126287	1	0	T	73524270	T	T	73524270	3	4	251	1	0	0	0	0	1	0	0	0	17649	1319	46	4	171	4	ZCCHC13	23	73524270	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	55780124	73524270	81746290	79	45988											
RNF128	79589	broad.mit.edu	37	chrX	105937342	105937342	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctatgtgactgtgacttattAcaatgaaaccagcaactaca	15	11	6	9	0	0	3	0	3	0	0	0	3	0	3	1	0	5	1	1	0	7	4			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chrX:105937342A>G	uc004emk.2	+	1	275	c.110A>G	c.(109-111)TAC>TGC	p.Y37C		NM_024539	NP_078815	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTGACTTATTACAATGAAACC	0.388													24	90					0	0	0	0	G	105937342	G	G	105937342	3	3	251	1	0	0	0	0	1	0	0	0	13501	391	14	5	112	5	RNF128	23	105937342	Missense_Mutation	SNP	A	TCGA-CV-7413-01A-11D-2078-08	32413072	105937342	49333218	80	45989											
MORC4	79710	broad.mit.edu	37	chrX	106228467	106228468	+	Frame_Shift_Ins	INS	-	T	T																															tgaatcctcggtaataatcaINSttttttgtaaaatcaaatat																										TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chrX:106228467_106228468insT	uc004emu.3	-	5	775_776	c.532_533insA	c.(532-534)ATGfs	p.M178fs	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Frame_Shift_Ins_p.M178fs|MORC4_uc004emw.3_Intron	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	178							ATP binding|zinc ion binding			ovary(1)	1						GGTAATAATCATTTTTTGTAAA	0.361													---	---	---								T	106228468	T	T	106228467	7	5	251	1	0	1	1	0	0	0	0	0	9757	217	8	0	2332	0	MORC4	23	106228467	Frame_Shift_Ins	INS	-	TCGA-CV-7413-01A-11D-2078-08	291125	106228467	49042093	81	45990											
AFF2	2334	broad.mit.edu	37	chrX	148055022	148055022	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgagaaatttggcaaagctGtgaattatgctgatgccgcc	11	11	11	8	2	0	3	0	2	0	1	1	4	0	3	2	1	3	3	2	1	4	2			TCGA-CV-7413-01A-11D-2078-08	TCGA-CV-7413-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	be482a19-0de0-4e60-a831-9ebe8545a6f3	741ec714-2c58-4d0c-a373-be69346da938	g.chrX:148055022G>A	uc004fcp.2	+	16	3768	c.3289G>A	c.(3289-3291)GTG>ATG	p.V1097M	AFF2_uc004fcq.2_Missense_Mutation_p.V1087M|AFF2_uc004fcr.2_Missense_Mutation_p.V1058M|AFF2_uc011mxb.1_Missense_Mutation_p.V1062M|AFF2_uc004fcs.2_Missense_Mutation_p.V1062M|AFF2_uc011mxc.1_Missense_Mutation_p.V738M	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1097					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TGGCAAAGCTGTGAATTATGC	0.408													25	85					0	0	0	0	A	148055022	A	A	148055022	3	1	251	1	0	0	0	0	1	0	0	0	357	1377	48	4	3406	4	AFF2	23	148055022	Missense_Mutation	SNP	G	TCGA-CV-7413-01A-11D-2078-08	41826555	148055022	7215538	82	45991											
CA6	765	broad.mit.edu	37	chr1	9034714	9034714	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctgaattccagttttaccTacataagattgaggaaattc	13	14	6	8	0	1	3	0	2	1	1	3	4	2	4	2	1	2	1	2	1	5	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:9034714T>G	uc001apm.2	+	8	902	c.878T>G	c.(877-879)CTA>CGA	p.L293R	CA6_uc009vmn.2_Missense_Mutation_p.L233R	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	293					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTTTTACCTACATAAGATT	0.383													8	10					0	0	0	0	G	9034714	G	G	9034714	3	3	252	1	0	0	0	0	1	0	0	0	2533	1522	53	5	908	5	CA6	1	9034714	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08		9034714	240215907	1	45992											
SLC2A5	6518	broad.mit.edu	37	chr1	9097693	9097693	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttcagttcctccttttcCgggtacacttcagacacctt	6	16	5	14	1	3	1	2	0	1	1	6	1	6	1	4	1	1	2	4	1	1	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:9097693C>T	uc001apo.2	-	12	1750	c.1458G>A	c.(1456-1458)CCG>CCA	p.P486P	SLC2A5_uc010nzy.1_Silent_p.P427P|SLC2A5_uc010nzz.1_Silent_p.P371P|SLC2A5_uc010oaa.1_Silent_p.P442P|SLC2A5_uc010oab.1_Silent_p.P486P	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	486	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCTCCTTTTCCGGGTACACTT	0.507													49	75					0	0	0	0	T	9097693	T	T	9097693	2	4	252	1	0	0	0	0	0	0	0	1	14612	639	23	1		1	SLC2A5	1	9097693	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	62979	9097693	240152928	2	45993											
CLSTN1	22883	broad.mit.edu	37	chr1	9794124	9794124	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggctctcctgctcgtggttCagctcctctccctccaccgt	3	12	8	18	2	3	0	1	0	2	0	8	0	5	0	5	2	2	4	5	2	0	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:9794124C>G	uc001aqh.2	-	15	2946	c.2187G>C	c.(2185-2187)CTG>CTC	p.L729L	CLSTN1_uc001aqi.2_Silent_p.L719L|CLSTN1_uc010oag.1_Silent_p.L710L|CLSTN1_uc001aqf.2_5'Flank	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	calsyntenin 1 isoform 1	729	Extracellular (Potential).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		GCTCGTGGTTCAGCTCCTCTC	0.572													18	30					0	0	0	0	G	9794124	G	G	9794124	2	3	252	1	0	0	0	0	0	0	0	1	3576	813	29	2		2	CLSTN1	1	9794124	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	696431	9794124	239456497	3	45994											
CROCC	9696	broad.mit.edu	37	chr1	17266512	17266512	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgcctgcgggacaagaccGacggcgccatgcaggcccac	9	2	14	16	5	0	1	0	0	0	1	0	3	0	2	4	3	3	1	4	3	1	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:17266512G>A	uc001azt.2	+	13	1801	c.1732G>A	c.(1732-1734)GAC>AAC	p.D578N	CROCC_uc009voy.1_Missense_Mutation_p.D281N|CROCC_uc009voz.1_Missense_Mutation_p.D341N|CROCC_uc001azu.2_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	578	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GGACAAGACCGACGGCGCCAT	0.706													6	33					0	0	0	0	A	17266512	A	A	17266512	3	1	252	1	0	0	0	0	1	0	0	0	3908	1058	37	1	1782	1	CROCC	1	17266512	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	7472388	17266512	231984109	4	45995											
YRDC	79693	broad.mit.edu	37	chr1	38272639	38272639	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatgatcaggaatccgaaTgcctacaagctgtaaggcaa	15	7	10	9	1	1	1	1	1	0	0	2	3	2	2	2	2	4	4	2	2	6	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:38272639T>C	uc001cca.1	-	3	527	c.514A>G	c.(514-516)ATT>GTT	p.I172V	C1orf122_uc001ccb.1_5'Flank	NM_024640	NP_078916	Q86U90	YRDC_HUMAN	ischemia/reperfusion inducible protein	172	YrdC-like.				negative regulation of transport	membrane|mitochondrion					0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GGAATCCGAATGCCTACAAGC	0.498													17	20					0	0	0	0	C	38272639	C	C	38272639	3	2	252	1	0	0	0	0	1	0	0	0	17562	1464	51	5	337	5	YRDC	1	38272639	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	21006127	38272639	210977982	5	45996											
ELOVL1	64834	broad.mit.edu	37	chr1	43830081	43830081	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taatccgtagtacaggtacaTtatgacatgcacggaagagt	14	10	10	7	2	0	2	0	1	0	1	1	3	1	3	1	2	3	4	1	2	6	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:43830081T>C	uc001ciz.2	-	8	775	c.532A>G	c.(532-534)ATG>GTG	p.M178V	ELOVL1_uc001cja.2_Missense_Mutation_p.M178V|ELOVL1_uc001cjb.2_Missense_Mutation_p.M178V|ELOVL1_uc001cjc.2_RNA|ELOVL1_uc010okh.1_Missense_Mutation_p.M151V	NM_022821	NP_073732	Q9BW60	ELOV1_HUMAN	elongation of very long chain fatty acids-like	178	Helical; (Potential).				fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|sphingolipid biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	fatty acid elongase activity|protein binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TACAGGTACATTATGACATGC	0.522													66	105					0	0	0	0	C	43830081	C	C	43830081	3	2	252	1	0	0	0	0	1	0	0	0	5097	1493	52	5	315	5	ELOVL1	1	43830081	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	5557442	43830081	205420540	6	45997											
CYP4A11	1579	broad.mit.edu	37	chr1	47403778	47403778	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatgtctccacccatttcTgaatccgttgtagctcctgg	7	13	9	12	1	2	1	0	1	2	0	5	2	4	2	4	2	1	3	4	2	3	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:47403778T>G	uc001cqp.3	-	2	278	c.227A>C	c.(226-228)CAG>CCG	p.Q76P	CYP4A11_uc001cqq.2_Missense_Mutation_p.Q76P|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	76					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	CACCCATTTCTGAATCCGTTG	0.488													26	53					0	0	0	0	G	47403778	G	G	47403778	3	3	252	1	0	0	0	0	1	0	0	0	4200	1580	55	5	1376	5	CYP4A11	1	47403778	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	3573697	47403778	201846843	7	45998											
ZFYVE9	9372	broad.mit.edu	37	chr1	52759159	52759159	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttgggacattccttcttCagtcaaagtttccttggcag	9	14	8	10	0	3	0	2	0	1	0	5	1	5	1	2	2	1	2	2	2	2	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:52759159C>T	uc001cto.2	+	11	3232	c.3060C>T	c.(3058-3060)TTC>TTT	p.F1020F	ZFYVE9_uc001ctp.2_Silent_p.F961F	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	1020					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						ATTCCTTCTTCAGTCAAAGTT	0.348													15	25					0	0	0	0	T	52759159	T	T	52759159	2	4	252	1	0	0	0	0	0	0	0	1	17738	825	29	2		2	ZFYVE9	1	52759159	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5355381	52759159	196491462	8	45999											
COL11A1	1301	broad.mit.edu	37	chr1	103427750	103427750	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgagctccaggaagaccTctttcccctgggaaaccacg	10	7	9	15	1	1	2	0	1	1	1	3	4	3	4	6	2	2	1	6	2	2	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:103427750T>A	uc001dul.2	-	40	3414	c.3096A>T	c.(3094-3096)AGA>AGT	p.R1032S	COL11A1_uc001duk.2_Missense_Mutation_p.R228S|COL11A1_uc001dum.2_Missense_Mutation_p.R1044S|COL11A1_uc001dun.2_Missense_Mutation_p.R993S|COL11A1_uc009weh.2_Missense_Mutation_p.R916S	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1032	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGGAAGACCTCTTTCCCCTG	0.388													26	7					0	0	0	0	A	103427750	A	A	103427750	3	1	252	1	0	0	0	0	1	0	0	0	3682	1548	54	5	2436	5	COL11A1	1	103427750	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	50668591	103427750	145822871	9	46000											
FCRL3	115352	broad.mit.edu	37	chr1	157666065	157666065	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accatattttctccttcaatCagctgccctccggtgggccg	6	12	8	15	2	3	0	2	0	1	0	5	0	4	0	5	2	2	1	5	2	2	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:157666065C>G	uc001frb.2	-	7	1189	c.897G>C	c.(895-897)CTG>CTC	p.L299L	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.L299L|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.L25L|FCRL3_uc001frc.1_Silent_p.L299L	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	299	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CTCCTTCAATCAGCTGCCCTC	0.517													7	95					0	0	0	0	G	157666065	G	G	157666065	2	3	252	1	0	0	0	0	0	0	0	1	5828	813	29	2		2	FCRL3	1	157666065	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	54238315	157666065	91584556	10	46001											
ARHGAP30	257106	broad.mit.edu	37	chr1	161021182	161021182	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgctgtagagcagggcactCaaggccacgggtgagcctgg	8	6	17	10	1	1	2	1	1	0	1	1	2	1	2	2	4	3	4	2	4	2	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:161021182C>G	uc001fxl.2	-	10	1688	c.1342G>C	c.(1342-1344)GAG>CAG	p.E448Q	ARHGAP30_uc001fxk.2_Missense_Mutation_p.E448Q|ARHGAP30_uc001fxm.2_Missense_Mutation_p.E294Q|ARHGAP30_uc009wtx.2_Missense_Mutation_p.E121Q|ARHGAP30_uc001fxn.1_Missense_Mutation_p.E294Q	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	448					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GCAGGGCACTCAAGGCCACGG	0.433													6	49					0	0	0	0	G	161021182	G	G	161021182	3	3	252	1	0	0	0	0	1	0	0	0	879	835	29	2	1975	2	ARHGAP30	1	161021182	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3355117	161021182	88229439	11	46002											
TOR1AIP2	163590	broad.mit.edu	37	chr1	179815318	179815318	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctgagtccatgtggttgaagGaggtgggagtgtcagagttg	8	11	18	4	0	1	3	1	2	0	1	2	5	2	5	1	4	0	2	1	4	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:179815318G>C	uc001gnk.2	-	6	1689	c.1301C>G	c.(1300-1302)TCC>TGC	p.S434C	TOR1AIP2_uc001gnl.2_Missense_Mutation_p.S434C	NM_145034	NP_659471	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	434						endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1						GTGGTTGAAGGAGGTGGGAGT	0.502													5	61					0	0	0	0	C	179815318	C	C	179815318	3	2	252	1	0	0	0	0	1	0	0	0	16440	1174	41	2	115	2	TOR1AIP2	1	179815318	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	18794136	179815318	69435303	12	46003											
DHX9	1660	broad.mit.edu	37	chr1	182845596	182845596	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atataggaagccatcggtatCagattctacccctgcattct	11	12	7	11	1	3	1	1	0	2	1	4	2	3	2	3	2	3	2	3	2	5	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:182845596C>G	uc001gpr.2	+	18	2207	c.2044C>G	c.(2044-2046)CAG>GAG	p.Q682E	DHX9_uc001gps.2_Missense_Mutation_p.Q468E|DHX9_uc001gpt.2_5'Flank	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	682	Helicase C-terminal.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						CCATCGGTATCAGATTCTACC	0.383													6	56					0	0	0	0	G	182845596	G	G	182845596	3	3	252	1	0	0	0	0	1	0	0	0	4538	827	29	2	2110	2	DHX9	1	182845596	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3030278	182845596	66405025	13	46004											
CDK18	5129	broad.mit.edu	37	chr1	205499409	205499409	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaatccaagagtcgcatgtCagcagaggctgccctgagtc	10	8	12	11	1	1	4	1	2	0	2	4	4	2	4	2	1	2	3	2	1	2	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:205499409C>T	uc001hcr.2	+	14	1553	c.1334C>T	c.(1333-1335)TCA>TTA	p.S445L	CDK18_uc001hcp.2_Missense_Mutation_p.S415L|CDK18_uc001hcq.2_Missense_Mutation_p.S415L|CDK18_uc010prj.1_Missense_Mutation_p.S326L|CDK18_uc001hcs.2_Missense_Mutation_p.S326L|CDK18_uc009xbm.1_3'UTR|CDK18_uc001hct.2_RNA	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	413	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						AGTCGCATGTCAGCAGAGGCT	0.622													5	70					0	0	0	0	T	205499409	T	T	205499409	3	4	252	1	0	0	0	0	1	0	0	0	3149	838	29	2	1384	2	CDK18	1	205499409	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	22653813	205499409	43751212	14	46005											
SLC26A9	115019	broad.mit.edu	37	chr1	205892256	205892256	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgttgtgtgggcctcattCtccgcttctcctgcttcttg	1	18	9	13	1	5	0	1	0	4	0	7	0	5	0	3	1	1	3	3	1	0	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:205892256C>T	uc001hdq.2	-	16	1841	c.1727G>A	c.(1726-1728)AGA>AAA	p.R576K	SLC26A9_uc001hdo.2_Missense_Mutation_p.R244K|SLC26A9_uc001hdp.2_Missense_Mutation_p.R576K	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	576	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GGGCCTCATTCTCCGCTTCTC	0.517													28	78					0	0	0	0	T	205892256	T	T	205892256	3	4	252	1	0	0	0	0	1	0	0	0	14588	913	32	2	968	2	SLC26A9	1	205892256	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	392847	205892256	43358365	15	46006											
CR1	1378	broad.mit.edu	37	chr1	207787831	207787831	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagcagtgttccagtgtgtGaacgtgagtagaaagaacta	14	10	12	5	1	0	4	0	2	0	2	1	4	1	4	1	0	3	3	1	0	6	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:207787831G>T	uc001hfy.2	+	32	5448	c.5308G>T	c.(5308-5310)GAA>TAA	p.E1770*	CR1_uc001hfx.2_Nonsense_Mutation_p.E2220*	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1770	Extracellular (Potential).|Sushi 27.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TCCAGTGTGTGAACGTGAGTA	0.408													5	45					8.12818e-05	8.28756e-05	1	0	T	207787831	T	T	207787831	4	4	252	1	0	0	0	0	0	1	0	0	3855	1291	45	2	6816	2	CR1	1	207787831	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1895575	207787831	41462790	16	46007											
CAPN2	824	broad.mit.edu	37	chr1	223958200	223958200	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtaccatgaattcctatGaaatgcggaaggcattagaa	14	10	10	7	1	0	3	0	2	0	1	1	4	1	4	2	3	2	2	2	3	7	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:223958200G>A	uc001hob.3	+	18	2100	c.1876G>A	c.(1876-1878)GAA>AAA	p.E626K	CAPN2_uc010puy.1_Missense_Mutation_p.E548K|CAPN2_uc001hoc.2_Missense_Mutation_p.E207K	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	626	Domain IV.|EF-hand 2.|2.				proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		GAATTCCTATGAAATGCGGAA	0.393													4	37					0	0	0	0	A	223958200	A	A	223958200	3	1	252	1	0	0	0	0	1	0	0	0	2639	1291	45	2	1953	2	CAPN2	1	223958200	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	16170369	223958200	25292421	17	46008											
EXOC8	149371	broad.mit.edu	37	chr1	231473420	231473420	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgcttcacgtacagccgCgcctcaaaaccccctgactc	9	7	7	18	3	2	1	2	1	0	0	3	1	2	1	4	0	5	3	4	0	3	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:231473420C>T	uc001huq.2	-	1	159	c.72G>A	c.(70-72)GCG>GCA	p.A24A	C1orf124_uc001hur.2_5'Flank|C1orf124_uc001hus.2_5'Flank|C1orf124_uc001hut.2_5'Flank	NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	24					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				CGTACAGCCGCGCCTCAAAAC	0.677													6	50					0	0	0	0	T	231473420	T	T	231473420	2	4	252	1	0	0	0	0	0	0	0	1	5335	755	27	1		1	EXOC8	1	231473420	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	7515220	231473420	17777201	18	46009											
SIPA1L2	57568	broad.mit.edu	37	chr1	232615429	232615429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgacacgtggaacatgagttCgtagtctttgtatgtggtat	9	15	12	5	2	1	2	0	2	1	0	2	3	1	3	0	2	1	4	0	2	4	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:232615429C>T	uc001hvg.2	-	5	2187	c.2029G>A	c.(2029-2031)GAA>AAA	p.E677K		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	677	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AACATGAGTTCGTAGTCTTTG	0.458													5	57					0	0	0	0	T	232615429	T	T	232615429	3	4	252	1	0	0	0	0	1	0	0	0	14395	893	31	1	3207	1	SIPA1L2	1	232615429	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1142009	232615429	16635192	19	46010											
GPR137B	7107	broad.mit.edu	37	chr1	236347168	236347168	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcttacctaccaccttagtcGtttatttcttccgagttaga	8	17	5	11	2	2	1	0	0	2	1	4	2	3	1	4	0	2	2	4	0	5	8	rs147708340		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:236347168G>A	uc001hxq.2	+	5	1019	c.928G>A	c.(928-930)GTT>ATT	p.V310I	GPR137B_uc001hxr.1_Missense_Mutation_p.V92I|GPR137B_uc009xge.2_RNA	NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	310	Helical; (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			CACCTTAGTCGTTTATTTCTT	0.373													18	28					0	0	0	0	A	236347168	A	A	236347168	3	1	252	1	0	0	0	0	1	0	0	0	6684	1145	40	1	946	1	GPR137B	1	236347168	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3731739	236347168	12903453	20	46011											
OR6F1	343169	broad.mit.edu	37	chr1	247875239	247875239	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtgttcaggacgtggacAgctttgatcagatccaaggc	11	9	12	9	1	2	2	2	1	0	1	3	4	3	4	1	3	1	2	1	3	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr1:247875239A>C	uc001idj.1	-	1	819	c.819T>G	c.(817-819)GCT>GCG	p.A273A		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGACGTGGACAGCTTTGATCA	0.483													43	55					0	0	0	0	C	247875239	C	C	247875239	2	2	252	1	0	0	0	0	0	0	0	1	11255	175	7	5		5	OR6F1	1	247875239	Silent	SNP	A	TCGA-CV-7414-01A-11D-2078-08	11528071	247875239	1375382	21	46012											
SNTG2	54221	broad.mit.edu	37	chr2	1251141	1251141	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagaaactccaaggagctGactcctctcaaaccttcaga	14	8	7	12	0	2	3	2	2	1	2	5	5	4	4	3	1	3	1	3	1	3	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:1251141G>A	uc002qwq.2	+	12	1059	c.931G>A	c.(931-933)GAC>AAC	p.D311N	SNTG2_uc010ewi.2_Missense_Mutation_p.D184N	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	311	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CCAAGGAGCTGACTCCTCTCA	0.502													11	22					0	0	0	0	A	1251141	A	A	1251141	3	1	252	1	0	0	0	0	1	0	0	0	14939	1290	45	2	977	2	SNTG2	2	1251141	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08		1251141	241948232	22	46013											
GREB1	9687	broad.mit.edu	37	chr2	11733135	11733135	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtgtgcttactccctggccGagggcctctccgagatgttc	5	11	12	13	2	1	1	0	0	1	1	4	3	2	1	4	2	2	2	4	2	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:11733135G>A	uc002rbk.1	+	11	1879	c.1579G>A	c.(1579-1581)GAG>AAG	p.E527K	GREB1_uc002rbo.1_Missense_Mutation_p.E161K	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	527						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CTCCCTGGCCGAGGGCCTCTC	0.667													3	11					0	0	0	0	A	11733135	A	A	11733135	3	1	252	1	0	0	0	0	1	0	0	0	6799	1059	37	1	1725	1	GREB1	2	11733135	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	10481994	11733135	231466238	23	46014											
ITSN2	50618	broad.mit.edu	37	chr2	24480764	24480764	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaagatgcttactcttcccGttttacttcactcccaggaa	10	14	5	12	1	2	1	1	0	1	1	4	2	4	2	2	1	3	2	2	1	5	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:24480764G>A	uc002rfe.2	-	23	3139	c.2881C>T	c.(2881-2883)CGG>TGG	p.R961W	ITSN2_uc002rff.2_Missense_Mutation_p.R934W|ITSN2_uc002rfg.2_Missense_Mutation_p.R961W|ITSN2_uc002rfh.1_RNA	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	961					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACTCTTCCCGTTTTACTTCA	0.403													27	43					0	0	0	0	A	24480764	A	A	24480764	3	1	252	1	0	0	0	0	1	0	0	0	7966	1144	40	1	2335	1	ITSN2	2	24480764	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	12747629	24480764	218718609	24	46015											
ITSN2	50618	broad.mit.edu	37	chr2	24494796	24494796	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctttccataagttttcttttCcttgctttgctttcctttac	4	23	3	11	0	1	0	0	0	1	0	4	0	4	0	3	0	3	3	3	0	2	11			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:24494796C>A	uc002rfe.2	-	19	2354	c.2096G>T	c.(2095-2097)GGA>GTA	p.G699V	ITSN2_uc002rff.2_Missense_Mutation_p.G672V|ITSN2_uc002rfg.2_Missense_Mutation_p.G699V	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	699	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					gttttcttttccttgctttgc	0.104													16	5					1.3612e-06	1.39966e-06	1	0	A	24494796	A	A	24494796	3	1	252	1	0	0	0	0	1	0	0	0	7966	855	30	2	3136	2	ITSN2	2	24494796	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	14032	24494796	218704577	25	46016											
PLB1	151056	broad.mit.edu	37	chr2	28812554	28812554	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaccaggaaggattgcctGacaactctttcttcgctcct	8	12	9	12	1	2	2	0	2	2	0	4	4	3	4	3	2	2	1	3	2	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:28812554G>A	uc002rmb.1	+	28	1933	c.1933G>A	c.(1933-1935)GAC>AAC	p.D645N	PLB1_uc010ezj.1_Missense_Mutation_p.D634N|PLB1_uc002rmc.2_Missense_Mutation_p.D333N|PLB1_uc002rmd.1_Missense_Mutation_p.D155N	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	645	4 X 308-326 AA approximate repeats.|2.|Extracellular (Potential).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					AGGATTGCCTGACAACTCTTT	0.498													7	72					0	0	0	0	A	28812554	A	A	28812554	3	1	252	1	0	0	0	0	1	0	0	0	12079	1290	45	2	2076	2	PLB1	2	28812554	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	4317758	28812554	214386819	26	46017											
C2orf71	388939	broad.mit.edu	37	chr2	29294945	29294945	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taagcttcttgacggatgttCtggtgggacagcctctgaca	8	12	12	9	1	3	2	0	2	3	0	3	4	3	4	1	3	2	2	1	3	1	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:29294945C>G	uc002rmt.1	-	1	2183	c.2183G>C	c.(2182-2184)AGA>ACA	p.R728T		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	728					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						GACGGATGTTCTGGTGGGACA	0.547													5	80					0	0	0	0	G	29294945	G	G	29294945	3	3	252	1	0	0	0	0	1	0	0	0	2201	913	32	2	1691	2	C2orf71	2	29294945	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	482391	29294945	213904428	27	46018											
PRKD3	23683	broad.mit.edu	37	chr2	37520323	37520323	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcatgtatttcatctgctGaggtaatcagctgcaaaatg	11	14	8	8	0	4	1	3	1	1	0	4	1	4	1	0	1	3	5	0	1	4	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:37520323G>C	uc002rqd.2	-	2	935	c.380C>G	c.(379-381)TCA>TGA	p.S127*	PRKD3_uc002rqf.1_Nonsense_Mutation_p.S127*	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	127					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				TTCATCTGCTGAGGTAATCAG	0.408													6	76					0	0	0	0	C	37520323	C	C	37520323	4	2	252	1	0	0	0	0	0	1	0	0	12582	1294	45	2	2360	2	PRKD3	2	37520323	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	8225378	37520323	205679050	28	46019											
TMEM178	130733	broad.mit.edu	37	chr2	39944277	39944277	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacagctggtccatcttttgCgcctggtgcagtttaggctt	5	15	11	10	1	1	0	0	0	1	0	2	0	2	0	2	3	4	4	2	3	2	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:39944277C>T	uc002rrt.2	+	4	805	c.780C>T	c.(778-780)TGC>TGT	p.C260C	TMEM178_uc010fam.1_Silent_p.C214C	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	260	Helical; (Potential).					integral to membrane					0		all_hematologic(82;0.248)				CCATCTTTTGCGCCTGGTGCA	0.493													55	71					0	0	0	0	T	39944277	T	T	39944277	2	4	252	1	0	0	0	0	0	0	0	1	16161	776	27	1		1	TMEM178	2	39944277	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	2423954	39944277	203255096	29	46020											
GKN1	56287	broad.mit.edu	37	chr2	69206027	69206027	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctgcaaccagactctttCaaaagaagacatgcattgtg	13	11	8	9	0	2	3	1	0	1	3	2	3	2	3	1	0	4	3	1	0	4	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:69206027C>T	uc002sfc.2	+	4	334	c.271C>T	c.(271-273)CAA>TAA	p.Q91*		NM_019617	NP_062563	Q9NS71	GKN1_HUMAN	18 kDa antrum mucosa protein precursor	91	BRICHOS.				digestion|positive regulation of cell division	extracellular region				breast(1)	1						CAGACTCTTTCAAAAGAAGAC	0.433													4	53					0	0	0	0	T	69206027	T	T	69206027	4	4	252	1	0	0	0	0	0	1	0	0	6461	827	29	2	285	2	GKN1	2	69206027	Nonsense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	29261750	69206027	173993346	30	46021											
DNAH6	1768	broad.mit.edu	37	chr2	84777021	84777021	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttttcaagctttattcGtctaaacgactatctaattg	10	19	4	8	2	4	0	1	0	3	0	5	1	4	0	0	0	2	1	0	0	6	10	rs145235960		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:84777021G>A	uc010fgb.2	+	9	1462	c.1325G>A	c.(1324-1326)CGT>CAT	p.R442H	DNAH6_uc002soo.2_Missense_Mutation_p.R21H|DNAH6_uc002sop.2_Missense_Mutation_p.R21H	NM_001370	NP_001361	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy polypeptide 6	442	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1						AGCTTTATTCGTCTAAACGAC	0.303													14	23					0	0	0	0	A	84777021	A	A	84777021	3	1	252	1	0	0	0	0	1	0	0	0	4627	1145	40	1	1355	1	DNAH6	2	84777021	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	15570994	84777021	158422352	31	46022											
POLR1A	25885	broad.mit.edu	37	chr2	86302279	86302279	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcctcattgatgaccatGgaggctcctgggtgcacatt	7	11	11	12	1	1	2	1	2	0	0	3	3	3	3	4	3	1	2	4	3	0	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:86302279G>A	uc002sqs.2	-	12	1864	c.1485C>T	c.(1483-1485)TCC>TCT	p.S495S		NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	495					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TGATGACCATGGAGGCTCCTG	0.602													20	6					0	0	0	0	A	86302279	A	A	86302279	2	1	252	1	0	0	0	0	0	0	0	1	12264	1335	47	4		4	POLR1A	2	86302279	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1525258	86302279	156897094	32	46023											
AFF3	3899	broad.mit.edu	37	chr2	100266105	100266105	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tacctgtcagagagagcgcgGagagccgttctctgagctgc	8	8	14	11	3	2	4	1	1	1	3	3	6	2	4	2	1	5	2	2	1	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:100266105G>A	uc002tag.2	-	12	1403	c.1167C>T	c.(1165-1167)CTC>CTT	p.L389L	AFF3_uc002taf.2_Silent_p.L414L|AFF3_uc010fiq.1_Silent_p.L389L|AFF3_uc010yvr.1_Silent_p.L542L|AFF3_uc002tah.1_Silent_p.L414L	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	389					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						AGAGAGCGCGGAGAGCCGTTC	0.363													8	76					0	0	0	0	A	100266105	A	A	100266105	2	1	252	1	0	0	0	0	0	0	0	1	358	1161	41	2		2	AFF3	2	100266105	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	13963826	100266105	142933268	33	46024											
FOXD4L1	200350	broad.mit.edu	37	chr2	114257406	114257406	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgcctcccaggacatgttCgacaatggcagctttctccg	7	9	9	16	3	1	0	0	0	1	0	4	2	2	1	4	2	1	3	4	2	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:114257406C>T	uc002tjw.3	+	1	746	c.573C>T	c.(571-573)TTC>TTT	p.F191F		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	191	Fork-head.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						AGGACATGTTCGACAATGGCA	0.652													13	180					0	0	0	0	T	114257406	T	T	114257406	2	4	252	1	0	0	0	0	0	0	0	1	6032	883	31	1		1	FOXD4L1	2	114257406	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	13991301	114257406	128941967	34	46025											
TMEM177	80775	broad.mit.edu	37	chr2	120439145	120439145	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgccgcacggcctccctctCtgcagcctatgcctgtggtg	3	9	11	18	3	1	0	0	0	1	0	3	0	2	0	6	2	3	2	6	2	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:120439145C>G	uc010flg.1	+	2	1189	c.716C>G	c.(715-717)TCT>TGT	p.S239C	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Missense_Mutation_p.S239C|TMEM177_uc002tmd.2_Missense_Mutation_p.S239C|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	239						integral to membrane				ovary(1)	1	Colorectal(110;0.196)					GCCTCCCTCTCTGCAGCCTAT	0.607													16	33					0	0	0	0	G	120439145	G	G	120439145	3	3	252	1	0	0	0	0	1	0	0	0	16160	913	32	2	718	2	TMEM177	2	120439145	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	6181739	120439145	122760228	35	46026											
NEB	4703	broad.mit.edu	37	chr2	152398055	152398055	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgcttcttgcctgcagctCtgtagaccagctagacataa	9	12	8	12	0	3	2	0	0	3	2	3	2	3	2	2	0	5	5	2	0	3	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:152398055C>T	uc010fnx.2	-	108	15676	c.15485G>A	c.(15484-15486)AGA>AAA	p.R5162K	NEB_uc002txr.2_Missense_Mutation_p.R1585K	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5162	Nebulin 140.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCCTGCAGCTCTGTAGACCAG	0.358													7	90					0	0	0	0	T	152398055	T	T	152398055	3	4	252	1	0	0	0	0	1	0	0	0	10356	913	32	2	5286	2	NEB	2	152398055	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	31958910	152398055	90801318	36	46027											
BAZ2B	29994	broad.mit.edu	37	chr2	160194092	160194092	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agataccttctttcaatgttCcgctccaaatcagccagcct	10	12	5	14	1	3	1	2	0	1	1	5	1	5	1	5	0	3	2	5	0	3	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:160194092C>T	uc002uao.2	-	32	5998	c.5646G>A	c.(5644-5646)CGG>CGA	p.R1882R	BAZ2B_uc002uap.2_Silent_p.R1846R	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1882					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TTTCAATGTTCCGCTCCAAAT	0.488													37	84					0	0	0	0	T	160194092	T	T	160194092	2	4	252	1	0	0	0	0	0	0	0	1	1334	842	30	2		2	BAZ2B	2	160194092	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	7796037	160194092	83005281	37	46028											
XIRP2	129446	broad.mit.edu	37	chr2	168107133	168107133	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaataaaattgccaaagaGaaaacagtacagcaccaagt	22	5	7	7	0	0	1	0	0	0	1	0	3	0	1	2	0	4	2	2	0	9	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:168107133G>T	uc002udx.2	+	8	9249	c.9231G>T	c.(9229-9231)GAG>GAT	p.E3077D	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E2902D|XIRP2_uc010fpq.2_Missense_Mutation_p.E2855D|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2902					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTGCCAAAGAGAAAACAGTAC	0.353													55	18					1.27862e-28	1.36486e-28	1	0	T	168107133	T	T	168107133	3	4	252	1	0	0	0	0	1	0	0	0	17498	933	33	2	9261	2	XIRP2	2	168107133	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	7913041	168107133	75092240	38	46029											
ZAK	51776	broad.mit.edu	37	chr2	174131080	174131080	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaatactgacacctcttcaGagaggggtcgatactcagac	12	8	10	11	1	3	3	2	1	1	2	4	5	3	3	1	2	2	1	1	2	3	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:174131080G>C	uc002uhz.2	+	20	2205	c.2005G>C	c.(2005-2007)GAG>CAG	p.E669Q	uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	669					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			CACCTCTTCAGAGAGGGGTCG	0.458													17	61					0	0	0	0	C	174131080	C	C	174131080	3	2	252	1	0	0	0	0	1	0	0	0	17580	943	33	2	2464	2	ZAK	2	174131080	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	6023947	174131080	69068293	39	46030											
TTN	7273	broad.mit.edu	37	chr2	179413442	179413442	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaatctgttgtatggatatCagcccgaaggctaaggttag	11	11	13	6	1	2	0	1	0	1	0	2	3	2	2	1	4	1	4	1	4	6	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:179413442C>G	uc010zfg.1	-	288	85431	c.85207G>C	c.(85207-85209)GAT>CAT	p.D28403H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D22098H|TTN_uc010zfi.1_Missense_Mutation_p.D22031H|TTN_uc010zfj.1_Missense_Mutation_p.D21906H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29330							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTATGGATATCAGCCCGAAGG	0.478													5	73					0	0	0	0	G	179413442	G	G	179413442	3	3	252	1	0	0	0	0	1	0	0	0	16803	826	29	2	15164	2	TTN	2	179413442	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5282362	179413442	63785931	40	46031											
TRAK2	66008	broad.mit.edu	37	chr2	202285154	202285154	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttaccagtgatgctctccGagtctctgtgattgctattc	7	15	8	11	1	2	2	0	2	2	0	5	3	2	2	2	0	3	2	2	0	2	4	rs146913241	byFrequency	TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:202285154G>A	uc002uyb.3	-	2	523	c.77C>T	c.(76-78)TCG>TTG	p.S26L	TRAK2_uc002uyc.2_Missense_Mutation_p.S26L	NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	26						early endosome|plasma membrane	GABA receptor binding				0						GATGCTCTCCGAGTCTCTGTG	0.398													11	88					0	0	0	0	A	202285154	A	A	202285154	3	1	252	1	0	0	0	0	1	0	0	0	16517	1059	37	1	2727	1	TRAK2	2	202285154	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	22871712	202285154	40914219	41	46032											
ILKAP	80895	broad.mit.edu	37	chr2	239079271	239079271	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgttgcaggctgcttcgtagCgggcgtcggctgcggacttc	3	11	16	11	5	0	0	0	0	0	0	3	1	0	1	0	4	4	6	0	4	1	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr2:239079271C>T	uc002vxv.2	-	12	1215	c.1085G>A	c.(1084-1086)CGC>CAC	p.R362H	ILKAP_uc010zns.1_Missense_Mutation_p.R294H|ILKAP_uc002vxw.2_Missense_Mutation_p.R242H	NM_030768	NP_110395	Q9H0C8	ILKAP_HUMAN	integrin-linked kinase-associated protein	362	PP2C-like.					cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			ovary(3)	3		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)		TGCTTCGTAGCGGGCGTCGGC	0.612													20	27					0	0	0	0	T	239079271	T	T	239079271	3	4	252	1	0	0	0	0	1	0	0	0	7753	768	27	1	97	1	ILKAP	2	239079271	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	36794117	239079271	4120102	42	46033											
BRPF1	7862	broad.mit.edu	37	chr3	9786777	9786777	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aatgactgcagccttccccgGagcagctcagactctgagtc	9	8	10	14	1	2	3	1	2	1	1	4	4	3	4	3	1	4	3	3	1	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:9786777G>C	uc003bse.2	+	10	3387	c.2988G>C	c.(2986-2988)CGG>CGC	p.R996R	BRPF1_uc003bsf.2_Silent_p.R1002R|BRPF1_uc003bsg.2_Silent_p.R995R|BRPF1_uc011ati.1_Silent_p.R901R	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	996	Required for RUNX1 and RUNX2 transcriptional activation.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					GCCTTCCCCGGAGCAGCTCAG	0.557													11	18					0	0	0	0	C	9786777	C	C	9786777	2	2	252	1	0	0	0	0	0	0	0	1	1525	1161	41	2		2	BRPF1	3	9786777	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08		9786777	188235653	43	46034											
SLC6A1	6529	broad.mit.edu	37	chr3	11072889	11072889	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttatgtcttcaaactcttTgactactactctgccagtgg	9	16	6	10	0	4	1	1	1	3	0	4	1	4	1	1	1	4	0	1	1	4	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:11072889T>C	uc010hdq.2	+	13	1761	c.1350T>C	c.(1348-1350)TTT>TTC	p.F450F		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	450					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TCAAACTCTTTGACTACTACT	0.498													25	95					0	0	0	0	C	11072889	C	C	11072889	2	2	252	1	0	0	0	0	0	0	0	1	14737	1809	63	5		5	SLC6A1	3	11072889	Silent	SNP	T	TCGA-CV-7414-01A-11D-2078-08	1286112	11072889	186949541	44	46035											
C3orf20	84077	broad.mit.edu	37	chr3	14799082	14799082	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagtgctggtgtttgggatCatctcaagccagaactacac	11	10	10	10	0	2	1	2	0	1	1	3	2	2	2	1	2	4	2	1	2	4	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:14799082C>T	uc003byy.2	+	13	2549	c.2145C>T	c.(2143-2145)ATC>ATT	p.I715I	C3orf20_uc003byz.2_Silent_p.I593I|C3orf20_uc003bza.2_Silent_p.I593I|C3orf20_uc003bzb.1_Silent_p.I216I|C3orf20_uc011avj.1_Silent_p.I42I	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	715						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						TGTTTGGGATCATCTCAAGCC	0.637													4	28					0	0	0	0	T	14799082	T	T	14799082	2	4	252	1	0	0	0	0	0	0	0	1	2223	816	29	2		2	C3orf20	3	14799082	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3726193	14799082	183223348	45	46036											
SATB1	6304	broad.mit.edu	37	chr3	18462478	18462478	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atactcagtcactgtctaaaGatcacctgccagaatttaaa	15	11	5	10	0	4	2	3	0	1	2	4	2	4	2	2	0	2	0	2	0	6	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:18462478G>C	uc003cbh.2	-	2	1717	c.-18C>G	c.(-20--16)ATCTT>ATGTT		SATB1_uc003cbi.2_Translation_Start_Site|SATB1_uc003cbj.2_Translation_Start_Site	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1						cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						ACTGTCTAAAGATCACCTGCC	0.418													7	49					0	0	0	0	C	18462478	C	C	18462478	1	2	252	1	0	0	0	0	0	0	0	0	13918	957	33	2		2	SATB1	3	18462478	Translation_Start_Site	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3663396	18462478	179559952	46	46037											
KAT2B	8850	broad.mit.edu	37	chr3	20181763	20181763	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaaatatgttggctatatCaaggattatgaaggagccac	15	10	9	7	0	1	1	1	1	0	0	1	3	1	3	2	3	1	2	2	3	7	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:20181763C>G	uc003cbq.2	+	13	2357	c.1911C>G	c.(1909-1911)ATC>ATG	p.I637M		NM_003884	NP_003875	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	637	N-acetyltransferase.				cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTGGCTATATCAAGGATTATG	0.328													5	44					0	0	0	0	G	20181763	G	G	20181763	3	3	252	1	0	0	0	0	1	0	0	0	8021	816	29	2	1961	2	KAT2B	3	20181763	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1719285	20181763	177840667	47	46038											
SCN11A	11280	broad.mit.edu	37	chr3	38888469	38888469	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcatactatctaggccatCagagccaccgagtaccctag	11	10	7	13	1	3	1	2	0	1	1	3	2	3	1	4	1	3	1	4	1	5	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:38888469C>G	uc011ays.1	-	26	5291	c.5092G>C	c.(5092-5094)GAT>CAT	p.D1698H		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1698					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCTAGGCCATCAGAGCCACCG	0.453													4	74					0	0	0	0	G	38888469	G	G	38888469	3	3	252	1	0	0	0	0	1	0	0	0	13978	826	29	2	287	2	SCN11A	3	38888469	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	18706706	38888469	159133961	48	46039											
SCN11A	11280	broad.mit.edu	37	chr3	38941542	38941542	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgatttttaggcacatttctGctataaaaatgctagtgaaa	14	15	7	5	0	1	2	0	2	1	0	1	2	1	2	0	1	2	3	0	1	7	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:38941542G>C	uc011ays.1	-	13	2064	c.1865C>G	c.(1864-1866)GCA>GGA	p.A622G		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	622	II.|Helical; Name=S2 of repeat II; (By similarity).				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GCACATTTCTGCTATAAAAAT	0.428													3	19					0	0	0	0	C	38941542	C	C	38941542	3	2	252	1	0	0	0	0	1	0	0	0	13978	1319	46	4	3566	4	SCN11A	3	38941542	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	53073	38941542	159080888	49	46040											
XCR1	2829	broad.mit.edu	37	chr3	46062824	46062824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggtcctgaggatctccaCgtagcagaacaggataatcc	12	7	11	11	1	1	2	0	1	1	1	4	4	3	4	3	3	2	2	3	3	3	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:46062824C>T	uc003cpe.2	-	3	840	c.616G>A	c.(616-618)GTG>ATG	p.V206M	uc003cpd.1_5'Flank|XCR1_uc003cpf.2_Missense_Mutation_p.V206M	NM_005283	NP_005274	P46094	XCR1_HUMAN	XC chemokine receptor 1	206	Helical; Name=5; (Potential).				chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		AGGATCTCCACGTAGCAGAAC	0.587													9	12					0	0	0	0	T	46062824	T	T	46062824	3	4	252	1	0	0	0	0	1	0	0	0	17493	536	19	1	389	1	XCR1	3	46062824	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	7121282	46062824	151959606	50	46041											
BSN	8927	broad.mit.edu	37	chr3	49699342	49699342	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctccagctgccatctcctCaaagcgcagcaagcaccgga	10	5	10	16	2	2	0	1	0	1	0	4	1	3	1	4	2	5	5	4	2	2	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:49699342C>G	uc003cxe.3	+	6	10178	c.10064C>G	c.(10063-10065)TCA>TGA	p.S3355*		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3355					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCCATCTCCTCAAAGCGCAGC	0.572													3	29					0	0	0	0	G	49699342	G	G	49699342	4	3	252	1	0	0	0	0	0	1	0	0	1535	838	29	2	10086	2	BSN	3	49699342	Nonsense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3636518	49699342	148323088	51	46042											
TEX264	51368	broad.mit.edu	37	chr3	51708516	51708516	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agactgggcggcttttcactGagagctgcagcatctctccc	7	10	11	13	1	2	2	1	1	1	2	4	3	3	2	1	2	3	4	1	2	0	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:51708516G>C	uc010hls.2	+	3	365	c.196G>C	c.(196-198)GAG>CAG	p.E66Q	TEX264_uc003dbk.3_Missense_Mutation_p.E66Q|TEX264_uc010hlt.2_Intron|TEX264_uc003dbl.3_Missense_Mutation_p.E66Q|TEX264_uc003dbm.3_Missense_Mutation_p.E105Q	NM_001129884	NP_001123356	Q9Y6I9	TX264_HUMAN	testis expressed 264 precursor	66						extracellular region					0				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)		GCTTTTCACTGAGAGCTGCAG	0.587													4	39					0	0	0	0	C	51708516	C	C	51708516	3	2	252	1	0	0	0	0	1	0	0	0	15849	1291	45	2	198	2	TEX264	3	51708516	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	2009174	51708516	146313914	52	46043											
RYBP	23429	broad.mit.edu	37	chr3	72428559	72428559	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacttgttgtgccaccagctGagaattgatccgaggttttc	8	13	10	10	1	0	2	0	2	0	1	2	4	1	2	3	1	2	3	3	1	1	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:72428559G>A	uc003dpe.2	-	2	265	c.148C>T	c.(148-150)CAG>TAG	p.Q50*		NM_012234	NP_036366	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	60					apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding				0		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		GCCACCAGCTGAGAATTGATC	0.388													16	18					0	0	0	0	A	72428559	A	A	72428559	4	1	252	1	0	0	0	0	0	1	0	0	13831	1299	45	2	520	2	RYBP	3	72428559	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	20720043	72428559	125593871	53	46044											
DPPA2	151871	broad.mit.edu	37	chr3	109028157	109028157	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtggagctgtaaattgctCatttgtttgaagtagatgac	10	16	11	4	0	1	3	1	2	0	1	1	4	1	4	0	1	2	5	0	1	4	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:109028157C>T	uc003dxo.2	-	4	449	c.202G>A	c.(202-204)GAG>AAG	p.E68K		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	68						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						GTAAATTGCTCATTTGTTTGA	0.363													5	112					0	0	0	0	T	109028157	T	T	109028157	3	4	252	1	0	0	0	0	1	0	0	0	4756	835	29	2	714	2	DPPA2	3	109028157	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	36599598	109028157	88994273	54	46045											
MUC13	56667	broad.mit.edu	37	chr3	124646819	124646819	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggttgttacagcatcagctGagttgccttggttggtggct	5	15	14	7	0	1	1	1	1	0	0	1	1	1	1	1	4	4	7	1	4	1	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:124646819G>C	uc003ehq.1	-	2	95	c.71C>G	c.(70-72)TCA>TGA	p.S24*		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	24	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						AGCATCAGCTGAGTTGCCTTG	0.428													5	110					0	0	0	0	C	124646819	C	C	124646819	4	2	252	1	0	0	0	0	0	1	0	0	10024	1294	45	2	1504	2	MUC13	3	124646819	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	15618662	124646819	73375611	55	46046											
MSL2	55167	broad.mit.edu	37	chr3	135870295	135870295	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caagggcagcgttggcctcgGcatgtaagaacacttggatt	10	9	13	9	2	0	1	0	0	0	1	1	2	0	2	1	4	2	4	1	4	3	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:135870295G>C	uc003eqx.1	-	2	2161	c.1428C>G	c.(1426-1428)TGC>TGG	p.C476W	MSL2_uc011bmb.1_Missense_Mutation_p.C402W	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	476					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						GTTGGCCTCGGCATGTAAGAA	0.478													21	48					0	0	0	0	C	135870295	C	C	135870295	3	2	252	1	0	0	0	0	1	0	0	0	9931	1195	42	4	309	4	MSL2	3	135870295	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	11223476	135870295	62152135	56	46047											
A4GNT	51146	broad.mit.edu	37	chr3	137850006	137850006	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttgaaagaaggcaaacaGaagaggcagctggacttcag	16	5	13	7	0	1	4	1	1	0	3	1	6	1	5	0	3	2	3	0	3	4	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:137850006G>C	uc003ers.2	-	2	295	c.93C>G	c.(91-93)TTC>TTG	p.F31L		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	31	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						AAGGCAAACAGAAGAGGCAGC	0.562													5	90					0	0	0	0	C	137850006	C	C	137850006	3	2	252	1	0	0	0	0	1	0	0	0	7	933	33	2	937	2	A4GNT	3	137850006	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1979711	137850006	60172424	57	46048											
COPB2	9276	broad.mit.edu	37	chr3	139093347	139093347	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaccatcttctgaacctgtGataatgattggcaactcagg	11	13	8	9	0	3	3	1	3	2	0	3	3	3	3	2	2	3	1	2	2	4	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:139093347G>A	uc003etf.3	-	7	865	c.735C>T	c.(733-735)ATC>ATT	p.I245I	COPB2_uc011bmv.1_Silent_p.I216I|COPB2_uc010hui.2_Silent_p.I216I|COPB2_uc011bmw.1_Silent_p.I245I	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	245	WD 6.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						CTGAACCTGTGATAATGATTG	0.388													33	72					0	0	0	0	A	139093347	A	A	139093347	2	1	252	1	0	0	0	0	0	0	0	1	3744	1280	45	2		2	COPB2	3	139093347	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1243341	139093347	58929083	58	46049											
PTX3	5806	broad.mit.edu	37	chr3	157160376	157160376	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtgtttgtggtgggtggaGaggagaacaaactggttgct	9	12	17	3	0	0	2	0	0	0	2	0	4	0	2	0	5	3	3	0	5	3	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:157160376G>C	uc003fbl.3	+	3	897	c.754G>C	c.(754-756)GAG>CAG	p.E252Q	VEPH1_uc003fbj.1_Intron|VEPH1_uc003fbk.1_Intron|VEPH1_uc010hvu.1_Intron	NM_002852	NP_002843	P26022	PTX3_HUMAN	pentraxin 3 precursor	252	Pentaxin.				inflammatory response	extracellular region				central_nervous_system(1)	1			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			GGTGGGTGGAGAGGAGAACAA	0.488													39	78					0	0	0	0	C	157160376	C	C	157160376	3	2	252	1	0	0	0	0	1	0	0	0	12887	943	33	2	764	2	PTX3	3	157160376	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	18067029	157160376	40862054	59	46050											
SI	6476	broad.mit.edu	37	chr3	164785231	164785231	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgggtccagtaaactcttTtacatactgatgaggaactt	11	14	9	7	0	1	2	0	2	1	0	2	3	2	3	1	2	4	1	1	2	5	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:164785231T>G	uc003fei.2	-	6	594	c.532A>C	c.(532-534)AAA>CAA	p.K178Q		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	178	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTAAACTCTTTTACATACTGA	0.343										HNSCC(35;0.089)			33	79					0	0	0	0	G	164785231	G	G	164785231	3	3	252	1	0	0	0	0	1	0	0	0	14362	1850	64	5	5123	5	SI	3	164785231	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	7624855	164785231	33237199	60	46051											
PRKCI	5584	broad.mit.edu	37	chr3	170011198	170011198	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgttgactggtgggctcttgGagtgctcatgtttgagatga	6	15	15	5	0	2	3	1	3	1	1	2	5	2	4	0	3	1	4	0	3	0	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:170011198G>C	uc003fgs.2	+	14	1557	c.1319G>C	c.(1318-1320)GGA>GCA	p.G440A	PRKCI_uc003fgt.2_5'UTR	NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	440	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TGGGCTCTTGGAGTGCTCATG	0.393													21	71					0	0	0	0	C	170011198	C	C	170011198	3	2	252	1	0	0	0	0	1	0	0	0	12576	1174	41	2	1373	2	PRKCI	3	170011198	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	5225967	170011198	28011232	61	46052											
MCF2L2	23101	broad.mit.edu	37	chr3	182923993	182923993	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaagctggcgaattgaaaGtgtcatcagctattataaag	14	11	9	7	1	2	1	2	1	0	0	3	2	3	1	1	1	2	2	1	1	7	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:182923993G>C	uc003fli.1	-	24	2812	c.2722C>G	c.(2722-2724)CTT>GTT	p.L908V		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	908	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CGAATTGAAAGTGTCATCAGC	0.408													8	95					0	0	0	0	C	182923993	C	C	182923993	3	2	252	1	0	0	0	0	1	0	0	0	9433	1029	36	4	650	4	MCF2L2	3	182923993	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	12912795	182923993	15098437	62	46053											
EIF4A2	1974	broad.mit.edu	37	chr3	186504984	186504984	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacaggctgttatttttctCaatacgaggcgcaaggtgga	11	11	11	8	2	1	0	1	0	1	0	2	2	1	1	0	4	1	3	0	4	4	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr3:186504984C>G	uc003fqs.2	+	8	879	c.840C>G	c.(838-840)CTC>CTG	p.L280L	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Silent_p.L281L|EIF4A2_uc003fqv.2_Silent_p.L185L|EIF4A2_uc003fqw.2_Silent_p.L185L|EIF4A2_uc011bsb.1_Silent_p.L153L|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	280	Helicase C-terminal.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		TTATTTTTCTCAATACGAGGC	0.423			T	BCL6	NHL								27	139					0	0	0	0	G	186504984	G	G	186504984	2	3	252	1	0	0	0	0	0	0	0	1	5049	813	29	2		2	EIF4A2	3	186504984	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3580991	186504984	11517446	63	46054											
ZNF595	152687	broad.mit.edu	37	chr4	59346	59346	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgtaacattcagggatgtGgccatagaattctcccctga	10	11	9	11	1	2	2	1	1	1	1	4	3	2	3	3	2	1	1	3	2	3	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:59346G>A	uc003fzv.1	+	2	183	c.27G>A	c.(25-27)GTG>GTA	p.V9V	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Silent_p.V9V|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	9					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TCAGGGATGTGGCCATAGAAT	0.413													53	173					0	0	0	0	A	59346	A	A	59346	2	1	252	1	0	0	0	0	0	0	0	1	18092	1335	47	4		4	ZNF595	4	59346	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08		59346	191094930	64	46055											
JAKMIP1	152789	broad.mit.edu	37	chr4	6055779	6055779	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acagatagagtctcttacttCgagttctagcactctgaatt	11	14	7	9	1	3	3	0	1	3	2	5	4	3	3	0	0	2	2	0	0	4	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:6055779C>T	uc003giu.3	-	13	2080	c.1804G>A	c.(1804-1806)GAA>AAA	p.E602K	JAKMIP1_uc010idb.1_Missense_Mutation_p.E602K|JAKMIP1_uc010idc.1_Missense_Mutation_p.E417K|JAKMIP1_uc010idd.1_Intron|JAKMIP1_uc011bwc.1_Missense_Mutation_p.E437K|JAKMIP1_uc003giv.3_Missense_Mutation_p.E602K|JAKMIP1_uc010ide.2_3'UTR	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	602	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TCTCTTACTTCGAGTTCTAGC	0.403													9	135					0	0	0	0	T	6055779	T	T	6055779	3	4	252	1	0	0	0	0	1	0	0	0	7979	893	31	1	802	1	JAKMIP1	4	6055779	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5996433	6055779	185098497	65	46056											
MAN2B2	23324	broad.mit.edu	37	chr4	6606982	6606982	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccatgcgggcaggtacttGgtgcctgtggcaaacgactg	8	8	15	10	2	0	0	0	0	0	0	0	1	0	0	2	4	5	3	2	4	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:6606982G>A	uc003gjf.1	+	11	1776	c.1740G>A	c.(1738-1740)TTG>TTA	p.L580L	MAN2B2_uc003gje.1_Silent_p.L580L|MAN2B2_uc011bwf.1_Silent_p.L529L	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	580					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						GCAGGTACTTGGTGCCTGTGG	0.612													39	7					0	0	0	0	A	6606982	A	A	6606982	2	1	252	1	0	0	0	0	0	0	0	1	9270	1339	47	4		4	MAN2B2	4	6606982	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	551203	6606982	184547294	66	46057											
SORCS2	57537	broad.mit.edu	37	chr4	7714493	7714493	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atcagcttccgctccgattgGgagctggtcaaggtggactt	7	11	13	10	2	2	0	2	0	0	0	4	3	4	2	2	4	2	3	2	4	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:7714493G>C	uc003gkb.3	+	15	1902	c.1902G>C	c.(1900-1902)TGG>TGC	p.W634C	SORCS2_uc011bwi.1_Missense_Mutation_p.W462C	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	634	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						GCTCCGATTGGGAGCTGGTCA	0.597													18	20					0	0	0	0	C	7714493	C	C	7714493	3	2	252	1	0	0	0	0	1	0	0	0	14995	1241	43	4	1960	4	SORCS2	4	7714493	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1107511	7714493	183439783	67	46058											
NSUN7	79730	broad.mit.edu	37	chr4	40752793	40752793	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	actcacttccctgcctctgtCcggtgggaaaagctcagctg	7	10	10	14	1	3	0	2	0	1	0	5	1	5	1	3	2	3	2	3	2	2	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:40752793C>A	uc003gvj.3	+	2	578	c.83C>A	c.(82-84)TCC>TAC	p.S28Y	NSUN7_uc003gvh.2_Missense_Mutation_p.S28Y|NSUN7_uc003gvi.3_Missense_Mutation_p.S28Y	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						CTGCCTCTGTCCGGTGGGAAA	0.527													54	52					3.68337e-26	3.92031e-26	1	0	A	40752793	A	A	40752793	3	1	252	1	0	0	0	0	1	0	0	0	10737	855	30	2	85	2	NSUN7	4	40752793	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	33038300	40752793	150401483	68	46059											
FRYL	285527	broad.mit.edu	37	chr4	48581067	48581067	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagctcacagctgtagagcaGtgtttaggaagattttcttg	10	14	11	6	0	2	2	1	0	1	2	2	3	2	3	0	1	3	5	0	1	4	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:48581067G>C	uc003gyh.1	-	23	3056	c.2451C>G	c.(2449-2451)CAC>CAG	p.H817Q	FRYL_uc003gyk.2_Missense_Mutation_p.H817Q	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	817					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CTGTAGAGCAGTGTTTAGGAA	0.393													40	62					0	0	0	0	C	48581067	C	C	48581067	3	2	252	1	0	0	0	0	1	0	0	0	6098	1020	36	4	6758	4	FRYL	4	48581067	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	7828274	48581067	142573209	69	46060											
REST	5978	broad.mit.edu	37	chr4	57777137	57777137	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggactggaaaacatggaactGagaagtttggaactcagcgt	14	8	13	6	1	1	1	1	1	0	1	1	6	1	5	0	4	4	1	0	4	5	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:57777137G>C	uc003hch.2	+	2	680	c.333G>C	c.(331-333)CTG>CTC	p.L111L	REST_uc003hci.2_Silent_p.L111L|REST_uc003hcj.1_Silent_p.L111L|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	111	Interaction with SIN3A.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					ACATGGAACTGAGAAGTTTGG	0.433													19	56					0	0	0	0	C	57777137	C	C	57777137	2	2	252	1	0	0	0	0	0	0	0	1	13299	1277	45	2		2	REST	4	57777137	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	9196070	57777137	133377139	70	46061											
ENAM	10117	broad.mit.edu	37	chr4	71509397	71509397	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctactacgttaataatgccGctggaccagaagaaagcact	14	8	9	10	2	0	2	0	0	0	2	0	3	0	3	2	1	4	4	2	1	6	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:71509397G>A	uc011caw.1	+	9	2535	c.2254G>A	c.(2254-2256)GCT>ACT	p.A752T		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	752					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			TAATAATGCCGCTGGACCAGA	0.453													27	38					0	0	0	0	A	71509397	A	A	71509397	3	1	252	1	0	0	0	0	1	0	0	0	5136	1087	38	1	2284	1	ENAM	4	71509397	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	13732260	71509397	119644879	71	46062											
MAPK10	5602	broad.mit.edu	37	chr4	87028405	87028405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttcacacacttcatgaggaCcagctcccggtacgctctct	8	10	8	15	2	3	1	2	1	1	0	5	2	4	2	2	2	2	4	2	2	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:87028405C>T	uc003hpq.2	-	4	404	c.337G>A	c.(337-339)GTC>ATC	p.V113I	MAPK10_uc010ikg.2_Missense_Mutation_p.V75I|MAPK10_uc003hpr.2_Missense_Mutation_p.V75I|MAPK10_uc003hps.2_Missense_Mutation_p.V113I|MAPK10_uc003hpt.2_Missense_Mutation_p.V113I|MAPK10_uc003hpu.2_Missense_Mutation_p.V113I|MAPK10_uc003hpv.2_5'UTR|MAPK10_uc010ikh.1_RNA|MAPK10_uc003hpo.2_5'UTR|MAPK10_uc011ccw.1_5'UTR|MAPK10_uc003hpp.2_5'UTR	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	113	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		TTCATGAGGACCAGCTCCCGG	0.438													28	36					0	0	0	0	T	87028405	T	T	87028405	3	4	252	1	0	0	0	0	1	0	0	0	9325	507	18	4	1102	4	MAPK10	4	87028405	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	15519008	87028405	104125871	72	46063											
SLC10A6	345274	broad.mit.edu	37	chr4	87754557	87754557	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttcccagggcggccacggtgGaacaggttgtcatactgatg	8	9	14	10	2	1	1	1	1	0	0	2	2	2	2	2	5	2	1	2	5	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:87754557G>A	uc003hqd.2	-	2	546	c.398C>T	c.(397-399)TCC>TTC	p.S133F		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	133	Cytoplasmic (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		GGCCACGGTGGAACAGGTTGT	0.443													19	61					0	0	0	0	A	87754557	A	A	87754557	3	1	252	1	0	0	0	0	1	0	0	0	14443	1174	41	2	755	2	SLC10A6	4	87754557	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	726152	87754557	103399719	73	46064											
ADH4	127	broad.mit.edu	37	chr4	100048496	100048496	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtacagtccagggctgctttCtgtgatggagcataaaagaa	12	10	12	7	0	1	2	0	1	1	1	2	3	2	3	1	2	3	4	1	2	4	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:100048496C>G	uc003hun.2	-	7	920	c.844_splice	c.e7-1	p.K282_splice	uc003hum.1_Intron|ADH4_uc011ced.1_Splice_Site_p.K301_splice	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit						alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	GGGCTGCTTTCTGTGATGGAG	0.284													10	45					0	0	0	0	G	100048496	G	G	100048496	5	3	252	1	0	0	0	0	0	0	1	0	310	927	32	2	311	2	ADH4	4	100048496	Splice_Site	SNP	C	TCGA-CV-7414-01A-11D-2078-08	12293939	100048496	91105780	74	46065											
KIAA1109	84162	broad.mit.edu	37	chr4	123160874	123160874	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagtttagtagtgatgtctCtcgaagtgatgagaatgtac	11	13	11	6	1	1	3	0	3	1	1	3	5	1	3	1	0	1	3	1	0	5	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:123160874C>G	uc003ieh.2	+	27	4082	c.4037C>G	c.(4036-4038)TCT>TGT	p.S1346C	KIAA1109_uc003iei.1_Missense_Mutation_p.S1099C|KIAA1109_uc010ins.1_Missense_Mutation_p.S689C|KIAA1109_uc003iek.2_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1346					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGTGATGTCTCTCGAAGTGAT	0.433													6	129					0	0	0	0	G	123160874	G	G	123160874	3	3	252	1	0	0	0	0	1	0	0	0	8247	913	32	2	4143	2	KIAA1109	4	123160874	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	23112378	123160874	67993402	75	46066											
KIAA0922	23240	broad.mit.edu	37	chr4	154502640	154502640	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaacttttcaaaagaatttGaagaaaacacacaacatttg	21	10	4	6	0	1	3	1	1	0	2	1	3	1	3	0	0	3	0	0	0	9	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:154502640G>C	uc003inm.3	+	9	872	c.820G>C	c.(820-822)GAA>CAA	p.E274Q	KIAA0922_uc010ipp.2_Missense_Mutation_p.E274Q|KIAA0922_uc010ipq.2_Missense_Mutation_p.E126Q	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	274	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				AAAAGAATTTGAAGAAAACAC	0.343													3	33					0	0	0	0	C	154502640	C	C	154502640	3	2	252	1	0	0	0	0	1	0	0	0	8240	1291	45	2	854	2	KIAA0922	4	154502640	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	31341766	154502640	36651636	76	46067											
SORBS2	8470	broad.mit.edu	37	chr4	186567862	186567862	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgatgacttgccaggttcaTattcaaaaatactccttggc	11	14	7	9	0	2	2	2	2	0	0	3	2	3	2	2	2	2	1	2	2	4	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:186567862T>C	uc003iyl.2	-	10	1502	c.644A>G	c.(643-645)TAT>TGT	p.Y215C	SORBS2_uc003iyh.2_Missense_Mutation_p.Y394C|SORBS2_uc011ckw.1_Missense_Mutation_p.Y284C|SORBS2_uc003iyi.2_Missense_Mutation_p.Y301C|SORBS2_uc011ckx.1_Missense_Mutation_p.Y261C|SORBS2_uc003iyk.2_Missense_Mutation_p.Y286C|SORBS2_uc003iym.2_Missense_Mutation_p.Y315C|SORBS2_uc003iyn.1_Missense_Mutation_p.Y261C|SORBS2_uc011cky.1_Missense_Mutation_p.Y278C|SORBS2_uc003iyp.2_Missense_Mutation_p.Y315C|SORBS2_uc011cku.1_Missense_Mutation_p.Y134C|SORBS2_uc011ckv.1_Missense_Mutation_p.Y119C|SORBS2_uc003iyd.2_Missense_Mutation_p.Y394C|SORBS2_uc003iye.2_Missense_Mutation_p.Y215C|SORBS2_uc003iya.2_Missense_Mutation_p.Y215C|SORBS2_uc003iyb.2_Missense_Mutation_p.Y215C|SORBS2_uc003iyc.2_Missense_Mutation_p.Y200C|SORBS2_uc003iyg.2_Missense_Mutation_p.Y301C|SORBS2_uc003iyf.2_Missense_Mutation_p.Y278C|SORBS2_uc003iyo.1_Missense_Mutation_p.Y119C	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	215						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GCCAGGTTCATATTCAAAAAT	0.428													26	12					0	0	0	0	C	186567862	C	C	186567862	3	2	252	1	0	0	0	0	1	0	0	0	14992	1406	49	5	3018	5	SORBS2	4	186567862	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	32065222	186567862	4586414	77	46068											
KLKB1	3818	broad.mit.edu	37	chr4	187173205	187173205	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaagcacacgcattgttggAggaacaaactcttcttgggg	12	9	11	9	1	2	0	0	0	2	0	2	2	2	2	0	4	3	3	0	4	3	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:187173205A>G	uc003iyy.2	+	11	1250	c.1179A>G	c.(1177-1179)GGA>GGG	p.G393G	KLKB1_uc011clc.1_Silent_p.G191G|KLKB1_uc011cld.1_Silent_p.G355G	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	393	Peptidase S1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GCATTGTTGGAGGAACAAACT	0.507													25	15					0	0	0	0	G	187173205	G	G	187173205	2	3	252	1	0	0	0	0	0	0	0	1	8451	291	11	5		5	KLKB1	4	187173205	Silent	SNP	A	TCGA-CV-7414-01A-11D-2078-08	605343	187173205	3981071	78	46069											
FAT1	2195	broad.mit.edu	37	chr4	187539265	187539266	+	Frame_Shift_Ins	INS	-	C	C																															tgatctgaattactctacttINSccccctggcaggttttcaac																										TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr4:187539265_187539266insC	uc003izf.2	-	10	8662_8663	c.8474_8475insG	c.(8473-8475)GGAfs	p.G2825fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2825	Extracellular (Potential).|Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTACTCTACTTCCCCCTGGCAG	0.436										HNSCC(5;0.00058)			---	---	---								C	187539266	C	C	187539265	7	5	252	1	0	1	1	0	0	0	0	0	5721	1770	62	0	5363	0	FAT1	4	187539265	Frame_Shift_Ins	INS	-	TCGA-CV-7414-01A-11D-2078-08	366060	187539265	3615011	79	46070											
LRRC14B	389257	broad.mit.edu	37	chr5	192316	192316	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagctggaggtggtgcacaaCgtgcggctgcatgcgggcca	8	6	17	10	3	0	0	0	0	0	0	0	1	0	1	1	5	6	4	1	5	2	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:192316C>T	uc003jal.1	+	1	691	c.663C>T	c.(661-663)AAC>AAT	p.N221N		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	221										skin(1)	1						TGGTGCACAACGTGCGGCTGC	0.716													3	4					0	0	0	0	T	192316	T	T	192316	2	4	252	1	0	0	0	0	0	0	0	1	9019	535	19	1		1	LRRC14B	5	192316	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08		192316	180722944	80	46071											
DNAH5	1767	broad.mit.edu	37	chr5	13885256	13885256	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtttctttctttttcctcGtgactgtcgtcaaaagcagg	7	16	8	10	2	3	1	1	1	2	0	6	1	4	1	1	1	1	2	1	1	2	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:13885256G>A	uc003jfd.2	-	19	2867	c.2825C>T	c.(2824-2826)ACG>ATG	p.T942M		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	942	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTTTTCCTCGTGACTGTCGT	0.423									Kartagener_syndrome				27	42					0	0	0	0	A	13885256	A	A	13885256	3	1	252	1	0	0	0	0	1	0	0	0	4626	1145	40	1	11293	1	DNAH5	5	13885256	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	13692940	13885256	167030004	81	46072											
RANBP3L	202151	broad.mit.edu	37	chr5	36265071	36265071	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctttctcaccttattatttGttttttctttagtcttgcaa	6	23	4	8	0	3	0	1	0	3	0	4	0	3	0	1	0	1	3	1	0	4	10			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:36265071G>T	uc003jkh.2	-	6	963	c.470C>A	c.(469-471)ACA>AAA	p.T157K	RANBP3L_uc011cow.1_Missense_Mutation_p.T182K	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	157					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CTTATTATTTGTTTTTTCTTT	0.418													36	63					1.36161e-19	1.4366e-19	1	0	T	36265071	T	T	36265071	3	4	252	1	0	0	0	0	1	0	0	0	13095	1377	48	4	963	4	RANBP3L	5	36265071	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	22379815	36265071	144650189	82	46073											
RASA1	5921	broad.mit.edu	37	chr5	86672284	86672284	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtttctgctcagctcccatAtaccattaaaaggtattgaa	12	13	7	9	0	2	1	1	1	1	0	3	1	3	1	2	2	3	4	2	2	6	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:86672284A>G	uc003kiw.2	+	16	2204	c.2086A>G	c.(2086-2088)ATA>GTA	p.I696V	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.I519V|RASA1_uc011ctv.1_Missense_Mutation_p.I529V|RASA1_uc011ctw.1_Missense_Mutation_p.I530V|RASA1_uc010jaw.2_Missense_Mutation_p.I518V	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	696					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		CAGCTCCCATATACCATTAAA	0.423													6	24					0	0	0	0	G	86672284	G	G	86672284	3	3	252	1	0	0	0	0	1	0	0	0	13125	449	16	5	2160	5	RASA1	5	86672284	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	50407213	86672284	94242976	83	46074											
ARSK	153642	broad.mit.edu	37	chr5	94938983	94938983	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attaacaaatgttgctgtaaAatttccagaaattacttatt	16	16	4	5	0	0	1	0	0	0	1	1	1	1	1	1	0	3	3	1	0	7	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:94938983A>C	uc003kld.2	+	8	1522	c.1364A>C	c.(1363-1365)AAA>ACA	p.K455T	ARSK_uc010jbg.2_Missense_Mutation_p.K296T|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	455						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		GTTGCTGTAAAATTTCCAGAA	0.308													3	3					0	0	0	0	C	94938983	C	C	94938983	3	2	252	1	0	0	0	0	1	0	0	0	998	14	1	5	1394	5	ARSK	5	94938983	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	8266699	94938983	85976277	84	46075											
TRIM36	55521	broad.mit.edu	37	chr5	114469606	114469606	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctctgctgcaaggactacaGattgaacccttgtaagctct	10	12	8	11	0	2	2	0	1	2	1	3	3	2	3	1	1	5	4	1	1	4	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:114469606G>C	uc003kqs.2	-	8	1994	c.1485C>G	c.(1483-1485)ATC>ATG	p.I495M	TRIM36_uc011cwc.1_Missense_Mutation_p.I483M|TRIM36_uc003kqt.2_Missense_Mutation_p.I340M	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	495	Fibronectin type-III.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		AAGGACTACAGATTGAACCCT	0.388													7	38					0	0	0	0	C	114469606	C	C	114469606	3	2	252	1	0	0	0	0	1	0	0	0	16577	932	33	2	713	2	TRIM36	5	114469606	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	19530623	114469606	66445654	85	46076											
HSPA4	3308	broad.mit.edu	37	chr5	132427045	132427045	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggagccaatggaaacagaTcagaatgcaaaggaggaaga	19	3	14	5	0	1	3	1	0	0	3	1	8	1	7	1	4	3	1	1	4	5	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:132427045T>C	uc003kyj.2	+	12	1820	c.1539T>C	c.(1537-1539)GAT>GAC	p.D513D		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	513					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGGAAACAGATCAGAATGCAA	0.438													15	28					0	0	0	0	C	132427045	C	C	132427045	2	2	252	1	0	0	0	0	0	0	0	1	7451	1432	50	5		5	HSPA4	5	132427045	Silent	SNP	T	TCGA-CV-7414-01A-11D-2078-08	17957439	132427045	48488215	86	46077											
PCDHB6	56130	broad.mit.edu	37	chr5	140531735	140531735	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctgctgagcgagcgagacGcagccaagcacaggctggtg	9	4	17	11	3	0	2	0	1	0	1	0	4	0	2	1	3	5	5	1	3	1	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:140531735G>A	uc003lir.2	+	1	1897	c.1897G>A	c.(1897-1899)GCA>ACA	p.A633T	PCDHB6_uc011dah.1_Missense_Mutation_p.A497T	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	633	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGAGCGAGACGCAGCCAAGCA	0.677													9	26					0	0	0	0	A	140531735	A	A	140531735	3	1	252	1	0	0	0	0	1	0	0	0	11600	1087	38	1	1899	1	PCDHB6	5	140531735	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	8104690	140531735	40383525	87	46078											
ARHGAP26	23092	broad.mit.edu	37	chr5	142500686	142500686	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatttcagaacattgtcattGagatcctaatagaaaaccac	17	11	5	8	0	2	3	2	1	0	3	3	4	3	3	2	0	2	0	2	0	6	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:142500686G>C	uc011dbj.1	+	18	1707	c.1672G>C	c.(1672-1674)GAG>CAG	p.E558Q	ARHGAP26_uc003lmt.2_Missense_Mutation_p.E558Q|ARHGAP26_uc003lmw.2_Missense_Mutation_p.E558Q	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	558	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATTGTCATTGAGATCCTAAT	0.443													10	35					0	0	0	0	C	142500686	C	C	142500686	3	2	252	1	0	0	0	0	1	0	0	0	875	1291	45	2	1742	2	ARHGAP26	5	142500686	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1968951	142500686	38414574	88	46079											
FBXO38	81545	broad.mit.edu	37	chr5	147807315	147807315	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgccttttcctttaggactCtgccacaaggggggtcttca	6	12	10	13	1	3	0	1	0	2	0	4	1	4	1	4	4	1	0	4	4	2	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:147807315C>G	uc003lpf.1	+	15	2578	c.2458C>G	c.(2458-2460)CTG>GTG	p.L820V	FBXO38_uc003lpg.1_Intron|FBXO38_uc003lph.2_Intron	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	820						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTTAGGACTCTGCCACAAGG	0.577													13	4					0	0	0	0	G	147807315	G	G	147807315	3	3	252	1	0	0	0	0	1	0	0	0	5778	912	32	2	2512	2	FBXO38	5	147807315	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5306629	147807315	33107945	89	46080											
FOXI1	2299	broad.mit.edu	37	chr5	169532981	169532981	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgagctccttcgacctgcCggcgccctccccacctcgct	4	8	8	21	4	0	1	0	1	0	0	4	2	2	1	7	1	2	2	7	1	0	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr5:169532981C>T	uc003mai.3	+	1	65	c.20C>T	c.(19-21)CCG>CTG	p.P7L	FOXI1_uc003maj.3_Missense_Mutation_p.P7L	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	7	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCGACCTGCCGGCGCCCTCC	0.697									Pendred_syndrome				8	3					0	0	0	0	T	169532981	T	T	169532981	3	4	252	1	0	0	0	0	1	0	0	0	6043	652	23	1	22	1	FOXI1	5	169532981	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	21725666	169532981	11382279	90	46081											
HUS1B	135458	broad.mit.edu	37	chr6	656504	656504	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggaggcgcgcaggctgggCggcaggcagtcccgccacac	6	3	17	15	5	0	0	0	0	0	0	2	1	1	1	2	6	0	4	2	6	0	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:656504C>T	uc003mtg.2	-	1	461	c.441G>A	c.(439-441)CCG>CCA	p.P147P	EXOC2_uc003mtd.2_Intron|EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_148959	NP_683762	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint protein B	147											0	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		GCAGGCTGGGCGGCAGGCAGT	0.716													15	24					0	0	0	0	T	656504	T	T	656504	2	4	252	1	0	0	0	0	0	0	0	1	7499	755	27	1		1	HUS1B	6	656504	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08		656504	170458563	91	46082											
DSP	1832	broad.mit.edu	37	chr6	7569532	7569532	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttccctctgtggggctgatCatccctcctccgaacccact	5	11	8	17	1	2	1	1	1	1	0	6	2	6	1	5	2	1	2	5	2	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:7569532C>T	uc003mxp.1	+	12	1812	c.1533C>T	c.(1531-1533)ATC>ATT	p.I511I	DSP_uc003mxq.1_Silent_p.I511I	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	511	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGGGGCTGATCATCCCTCCTC	0.577													21	45					0	0	0	0	T	7569532	T	T	7569532	2	4	252	1	0	0	0	0	0	0	0	1	4803	816	29	2		2	DSP	6	7569532	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	6913028	7569532	163545535	92	46083											
MRS2	57380	broad.mit.edu	37	chr6	24409763	24409763	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatttcagcatgtaatgagtAtcacagtcagaaacaatagg	16	10	9	6	0	3	2	3	1	0	1	3	3	3	2	0	1	2	3	0	1	5	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:24409763A>G	uc003neb.2	+	4	498	c.376A>G	c.(376-378)ATC>GTC	p.I126V	MRS2_uc003nea.2_Missense_Mutation_p.I126V|MRS2_uc011djl.1_Missense_Mutation_p.I126V|MRS2_uc011djm.1_RNA|MRS2_uc011djn.1_Intron|MRS2_uc003nec.2_Missense_Mutation_p.I3V	NM_020662	NP_065713	Q9HD23	MRS2_HUMAN	MRS2-like, magnesium homeostasis factor	126	Mitochondrial matrix (Potential).				ion transport	integral to membrane|mitochondrial inner membrane					0						TGTAATGAGTATCACAGTCAG	0.313													22	39					0	0	0	0	G	24409763	G	G	24409763	3	3	252	1	0	0	0	0	1	0	0	0	9904	449	16	5	390	5	MRS2	6	24409763	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	16840231	24409763	146705304	93	46084											
FAM65B	9750	broad.mit.edu	37	chr6	24843781	24843781	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgtcatcaggtagatttGactatagataaaagatacct	16	12	8	5	0	2	5	2	1	0	4	2	5	2	5	1	1	1	1	1	1	6	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:24843781G>C	uc003neo.1	-	14	1405	c.1229C>G	c.(1228-1230)TCA>TGA	p.S410*	FAM65B_uc011djs.1_Nonsense_Mutation_p.S389*|FAM65B_uc011dju.1_Nonsense_Mutation_p.S394*|FAM65B_uc003nep.2_Nonsense_Mutation_p.S360*|FAM65B_uc011djt.1_Nonsense_Mutation_p.S360*	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	410					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						AGGTAGATTTGACTATAGATA	0.413													3	17					0	0	0	0	C	24843781	C	C	24843781	4	2	252	1	0	0	0	0	0	1	0	0	5632	1304	45	2	2027	2	FAM65B	6	24843781	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	434018	24843781	146271286	94	46085											
HIST1H4C	8364	broad.mit.edu	37	chr6	26104378	26104378	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tttcttagagaacgttattcGagacgccgtcacctatacgg	10	12	9	10	5	2	2	1	0	1	2	3	4	2	2	2	1	2	1	2	1	5	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:26104378G>C	uc003ngi.2	+	1	203	c.203G>C	c.(202-204)CGA>CCA	p.R68P		NM_003542	NP_003533	P62805	H4_HUMAN	histone cluster 1, H4c	68					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						AACGTTATTCGAGACGCCGTC	0.527													9	29					0	0	0	0	C	26104378	C	C	26104378	3	2	252	1	0	0	0	0	1	0	0	0	7206	1058	37	3	205	3	HIST1H4C	6	26104378	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1260597	26104378	145010689	95	46086											
BRPF3	27154	broad.mit.edu	37	chr6	36193116	36193116	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gctggtgtgggccaagtgccGaggctacccctcctaccctg	5	8	13	15	1	0	0	0	0	0	0	1	1	1	0	6	3	3	2	6	3	3	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:36193116G>C	uc003olv.3	+	11	3478	c.3254G>C	c.(3253-3255)CGA>CCA	p.R1085P	BRPF3_uc010jwb.2_Missense_Mutation_p.R815P|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_Intron|BRPF3_uc011dtk.1_Missense_Mutation_p.R751P|BRPF3_uc010jwd.2_5'UTR	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	1085	PWWP.				histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GCCAAGTGCCGAGGCTACCCC	0.642													4	26					0	0	0	0	C	36193116	C	C	36193116	3	2	252	1	0	0	0	0	1	0	0	0	1526	1058	37	3	3292	3	BRPF3	6	36193116	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	10088738	36193116	134921951	96	46087											
KIF6	221458	broad.mit.edu	37	chr6	39311516	39311516	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaatgctctgtctggccttGatgaaggcgatgatgtccga	9	11	13	8	2	2	4	0	3	2	1	3	6	3	4	2	2	1	1	2	2	2	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:39311516G>C	uc003oot.2	-	22	2492	c.2397C>G	c.(2395-2397)ATC>ATG	p.I799M	KIF6_uc003oos.2_Missense_Mutation_p.I250M|KIF6_uc010jwz.1_Missense_Mutation_p.I174M|KIF6_uc010jxa.1_Missense_Mutation_p.I573M|KIF6_uc011dua.1_Missense_Mutation_p.I782M|KIF6_uc010jxb.1_Missense_Mutation_p.I743M	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	799					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						GTCTGGCCTTGATGAAGGCGA	0.582													15	35					0	0	0	0	C	39311516	C	C	39311516	3	2	252	1	0	0	0	0	1	0	0	0	8347	1280	45	2	55	2	KIF6	6	39311516	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3118400	39311516	131803551	97	46088											
HSP90AB1	3326	broad.mit.edu	37	chr6	44216418	44216418	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtggagacttttgcctttCaggcagaaattgcccaactc	10	11	10	10	0	1	2	1	0	0	2	2	3	1	2	2	3	3	1	2	3	2	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:44216418C>G	uc003oxa.1	+	2	136	c.52C>G	c.(52-54)CAG>GAG	p.Q18E	HSP90AB1_uc011dvr.1_Missense_Mutation_p.Q18E|HSP90AB1_uc003oxb.1_Missense_Mutation_p.Q18E|HSP90AB1_uc011dvs.1_5'UTR|HSP90AB1_uc003oxc.1_5'Flank	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	18					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding	p.Q18*(1)		lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTTTGCCTTTCAGGCAGAAAT	0.423													15	115					0	0	0	0	G	44216418	G	G	44216418	3	3	252	1	0	0	0	0	1	0	0	0	7441	827	29	2	54	2	HSP90AB1	6	44216418	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	4904902	44216418	126898649	98	46089											
ELOVL5	60481	broad.mit.edu	37	chr6	53156755	53156755	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaaaccatccttttactCtagtatctgaaaaattaaaa	18	12	4	7	0	2	2	0	1	2	1	3	3	3	2	2	0	2	1	2	0	9	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:53156755C>G	uc003pbq.1	-	3	513	c.65G>C	c.(64-66)AGA>ACA	p.R22T	ELOVL5_uc003pbr.1_Missense_Mutation_p.R22T|ELOVL5_uc011dwx.1_Missense_Mutation_p.R22T|ELOVL5_uc003pbs.1_Missense_Mutation_p.R22T	NM_021814	NP_068586	Q9NYP7	ELOV5_HUMAN	elongation of very long chain fatty acids-like	22					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Lung NSC(77;0.116)					TCCTTTTACTCTAGTATCTGa	0.274													30	26					0	0	0	0	G	53156755	G	G	53156755	3	3	252	1	0	0	0	0	1	0	0	0	5101	913	32	2	858	2	ELOVL5	6	53156755	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	8940337	53156755	117958312	99	46090											
DOPEY1	23033	broad.mit.edu	37	chr6	83863897	83863897	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtaatccttatctctttcAgttggagagcaattatggac	10	16	8	7	0	2	1	1	0	1	1	4	3	3	2	1	2	1	3	1	2	4	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:83863897A>T	uc003pjs.1	+	33	6650	c.6390_splice	c.e33-2	p.H2130_splice	DOPEY1_uc011dyy.1_Splice_Site_p.H2121_splice|DOPEY1_uc010kbl.1_Splice_Site_p.H2121_splice|DOPEY1_uc003pjt.2_Splice_Site	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1						protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TATCTCTTTCAGTTGGAGAGC	0.363													23	39					0	0	0	0	T	83863897	T	T	83863897	5	4	252	1	0	0	0	0	0	0	1	0	4729	202	7	5	6510	5	DOPEY1	6	83863897	Splice_Site	SNP	A	TCGA-CV-7414-01A-11D-2078-08	30707142	83863897	87251170	100	46091											
TSPYL4	23270	broad.mit.edu	37	chr6	116574228	116574228	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggccagaggatctgcgttcaTattccttgacaagcccctca	9	10	9	13	1	3	2	2	1	1	1	4	3	4	3	4	2	2	1	4	2	2	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:116574228T>C	uc003pwn.2	-	1	1034	c.944A>G	c.(943-945)TAT>TGT	p.Y315C	DSE_uc011ebf.1_5'Flank|TSPYL4_uc011ebe.1_Missense_Mutation_p.Y143C|uc003pwo.1_5'Flank	NM_021648	NP_067680	Q9UJ04	TSYL4_HUMAN	TSPY-like 4	315					nucleosome assembly	nucleus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.045)|OV - Ovarian serous cystadenocarcinoma(136;0.0666)|GBM - Glioblastoma multiforme(226;0.095)|Epithelial(106;0.125)		TCTGCGTTCATATTCCTTGAC	0.552													17	29					0	0	0	0	C	116574228	C	C	116574228	3	2	252	1	0	0	0	0	1	0	0	0	16728	1406	49	5	304	5	TSPYL4	6	116574228	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	32710331	116574228	54540839	101	46092											
GRM1	2911	broad.mit.edu	37	chr6	146673517	146673517	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctggccacgtgggcctctgcGatgccatgaagcccatcgac	7	7	12	15	3	1	1	0	1	1	0	2	3	1	1	4	2	3	0	4	2	1	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:146673517G>C	uc010khw.1	+	5	1788	c.1318G>C	c.(1318-1320)GAT>CAT	p.D440H	GRM1_uc010khv.1_Missense_Mutation_p.D440H|GRM1_uc003qll.2_Missense_Mutation_p.D440H|GRM1_uc011edz.1_Missense_Mutation_p.D440H|GRM1_uc011eea.1_Missense_Mutation_p.D440H	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	440	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGGCCTCTGCGATGCCATGAA	0.547													10	89					0	0	0	0	C	146673517	C	C	146673517	3	2	252	1	0	0	0	0	1	0	0	0	6835	1058	37	3	1332	3	GRM1	6	146673517	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	30099289	146673517	24441550	102	46093											
PNLDC1	154197	broad.mit.edu	37	chr6	160222146	160222146	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgcctgtttgttcacagtCtttttgatttgccatcggag	6	17	10	8	1	2	1	1	1	1	0	3	3	2	2	2	1	2	2	2	1	0	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:160222146C>G	uc003qsx.1	+	3	274	c.103C>G	c.(103-105)CTT>GTT	p.L35V	PNLDC1_uc003qsy.1_Missense_Mutation_p.L46V	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	35	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TGTTCACAGTCTTTTTGATTT	0.483													5	117					0	0	0	0	G	160222146	G	G	160222146	3	3	252	1	0	0	0	0	1	0	0	0	12203	927	32	2	109	2	PNLDC1	6	160222146	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	13548629	160222146	10892921	103	46094											
MAP3K4	4216	broad.mit.edu	37	chr6	161469773	161469773	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttagaacaacagagcgtgatCgtaaaaaaaatgtacagtgc	18	8	9	6	2	0	3	0	1	0	2	1	3	0	3	0	0	5	2	0	0	8	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:161469773C>G	uc003qtn.2	+	3	611	c.469C>G	c.(469-471)CAT>GAT	p.H157D	MAP3K4_uc010kkc.1_Missense_Mutation_p.R157G|MAP3K4_uc003qto.2_Missense_Mutation_p.H157D|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Translation_Start_Site	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	157					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		AGAGCGTGATCGTAAAAAAAA	0.403													7	75					0	0	0	0	G	161469773	G	G	161469773	3	3	252	1	0	0	0	0	1	0	0	0	9305	884	31	3	479	3	MAP3K4	6	161469773	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1247627	161469773	9645294	104	46095											
DLL1	28514	broad.mit.edu	37	chr6	170592437	170592437	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcacccttgaggtcctgcaCgaggttatagtccaccgctg	7	10	11	13	2	1	1	1	1	0	0	3	2	3	1	4	2	1	3	4	2	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr6:170592437C>T	uc003qxm.2	-	9	2400	c.1930G>A	c.(1930-1932)GTG>ATG	p.V644M		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	644	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		AGGTCCTGCACGAGGTTATAG	0.627													28	57					0	0	0	0	T	170592437	T	T	170592437	3	4	252	1	0	0	0	0	1	0	0	0	4588	536	19	1	253	1	DLL1	6	170592437	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	9122664	170592437	522630	105	46096											
ETV1	2115	broad.mit.edu	37	chr7	14027742	14027742	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagccagatctctgttaatGaattttcttttcctgacatt	9	18	6	8	0	2	4	0	3	2	1	4	4	3	4	2	0	1	1	2	0	2	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:14027742G>A	uc011jxq.1	-	4	841	c.102C>T	c.(100-102)TTC>TTT	p.F34F	ETV1_uc011jxn.1_5'Flank|ETV1_uc011jxo.1_5'Flank|ETV1_uc011jxp.1_5'Flank|ETV1_uc003ssw.3_Silent_p.F34F|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Silent_p.F34F|ETV1_uc011jxs.1_Silent_p.F34F|ETV1_uc010ktv.2_5'Flank	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	34					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						CTCTGTTAATGAATTTTCTTT	0.378			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								4	36					0	0	0	0	A	14027742	A	A	14027742	2	1	252	1	0	0	0	0	0	0	0	1	5301	1281	45	2		2	ETV1	7	14027742	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08		14027742	145110921	106	46097											
DNAH11	8701	broad.mit.edu	37	chr7	21745088	21745088	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctctgcaggttgtccagcTtgaggaactgttggctgtgc	5	13	14	9	0	1	1	0	1	1	0	2	2	2	2	1	3	5	6	1	3	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:21745088T>G	uc003svc.2	+	40	6531	c.6500T>G	c.(6499-6501)CTT>CGT	p.L2167R		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2167	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTTGTCCAGCTTGAGGAACTG	0.433									Kartagener_syndrome				7	12					0	0	0	0	G	21745088	G	G	21745088	3	3	252	1	0	0	0	0	1	0	0	0	4621	1609	56	5	6655	5	DNAH11	7	21745088	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	7717346	21745088	137393575	107	46098											
FZD9	8326	broad.mit.edu	37	chr7	72849813	72849813	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcggccgcggggcccggAggccggagggactgctcgct	4	3	20	14	6	0	0	0	0	0	0	1	3	0	3	3	7	2	3	3	7	0	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:72849813A>G	uc003tyb.2	+	1	1705	c.1476A>G	c.(1474-1476)GGA>GGG	p.G492G		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	492	Extracellular (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				CGGGGCCCGGAGGCCGGAGGG	0.652													4	40					0	0	0	0	G	72849813	G	G	72849813	2	3	252	1	0	0	0	0	0	0	0	1	6171	291	11	5		5	FZD9	7	72849813	Silent	SNP	A	TCGA-CV-7414-01A-11D-2078-08	51104725	72849813	86288850	108	46099											
GTF2IRD1	9569	broad.mit.edu	37	chr7	73952488	73952488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagacaagggcagcatgtctGaagactgtgggccaggtgag	11	6	16	8	0	1	4	0	2	1	2	1	4	1	4	1	3	1	2	1	3	2	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:73952488G>A	uc003uaq.2	+	12	1825	c.1432G>A	c.(1432-1434)GAA>AAA	p.E478K	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.E510K|GTF2IRD1_uc003uap.2_Missense_Mutation_p.E478K|GTF2IRD1_uc003uar.1_Missense_Mutation_p.E478K	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	478						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						CAGCATGTCTGAAGACTGTGG	0.642													5	65					0	0	0	0	A	73952488	A	A	73952488	3	1	252	1	0	0	0	0	1	0	0	0	6907	1291	45	2	1474	2	GTF2IRD1	7	73952488	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1102675	73952488	85186175	109	46100											
CACNA2D1	781	broad.mit.edu	37	chr7	81964507	81964507	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatatccctggctgcaatttCtaccagctggcgtgcattat	9	13	8	11	1	1	0	0	0	1	0	2	0	2	0	2	2	4	4	2	2	5	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:81964507C>G	uc003uhr.1	-	3	494	c.238G>C	c.(238-240)GAA>CAA	p.E80Q		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	80	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GCTGCAATTTCTACCAGCTGG	0.343													57	106					0	0	0	0	G	81964507	G	G	81964507	3	3	252	1	0	0	0	0	1	0	0	0	2560	922	32	2	3185	2	CACNA2D1	7	81964507	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	8012019	81964507	77174156	110	46101											
PCLO	27445	broad.mit.edu	37	chr7	82595320	82595320	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgagatttaagtaagtcatGtttctgttcttctggggctg	7	18	11	5	0	4	1	1	1	3	1	4	2	4	1	0	2	0	4	0	2	2	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:82595320G>A	uc003uhx.2	-	4	4073	c.3784C>T	c.(3784-3786)CAT>TAT	p.H1262Y	PCLO_uc003uhv.2_Missense_Mutation_p.H1262Y	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1201					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGTAAGTCATGTTTCTGTTCT	0.418													74	96					0	0	0	0	A	82595320	A	A	82595320	3	1	252	1	0	0	0	0	1	0	0	0	11637	1377	48	4	11749	4	PCLO	7	82595320	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	630813	82595320	76543343	111	46102											
C7orf63	79846	broad.mit.edu	37	chr7	89929196	89929196	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaagttgaaccaaaaaaaaTtctgtaatctaatacttgga	19	12	5	5	0	2	1	0	1	2	0	2	2	2	2	1	1	2	2	1	1	10	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:89929196T>A	uc010lep.2	+	17	2124	c.1873T>A	c.(1873-1875)TTC>ATC	p.F625I	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_Missense_Mutation_p.F300I|C7orf63_uc011khj.1_Missense_Mutation_p.F607I|C7orf63_uc011khk.1_Missense_Mutation_p.F187I	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	625							binding			ovary(1)	1						CCAAAAAAAATTCTGTAATCT	0.323													8	10					0	0	0	0	A	89929196	A	A	89929196	3	1	252	1	0	0	0	0	1	0	0	0	2420	1493	52	5	1939	5	C7orf63	7	89929196	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	7333876	89929196	69209467	112	46103											
FAM133B	257415	broad.mit.edu	37	chr7	92195342	92195342	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acttgctgttgctttttctcGttcttcactgcttttcttct	2	23	5	11	1	5	0	1	0	4	0	6	0	5	0	0	0	3	5	0	0	0	9			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:92195342G>A	uc003umc.2	-	10	744	c.643C>T	c.(643-645)CGA>TGA	p.R215*	FAM133B_uc003umb.2_Nonsense_Mutation_p.R205*|FAM133B_uc003umd.2_RNA	NM_152789	NP_690002	Q5BKY9	F133B_HUMAN	hypothetical protein LOC257415 isoform 1	215	Lys-rich.							p.R215Q(1)		ovary(1)	1	all_cancers(62;7.39e-11)|all_epithelial(64;7.03e-10)|Breast(17;0.00201)|all_lung(186;0.0384)|Lung NSC(181;0.053)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;9.78e-06)|all cancers(6;1.67e-05)|Epithelial(20;0.113)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GCTTTTTCTCGTTCTTCACTG	0.323													11	16					0	0	0	0	A	92195342	A	A	92195342	4	1	252	1	0	0	0	0	0	1	0	0	5472	1153	40	1	108	1	FAM133B	7	92195342	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	2266146	92195342	66943321	113	46104											
SPDYE3	441272	broad.mit.edu	37	chr7	99917593	99917593	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcactgggtgtgggcgcgaGatcgcgcccacctttcctag	6	8	14	13	4	0	1	0	0	0	1	2	2	1	1	3	2	1	1	3	2	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:99917593G>C	uc003uug.1	+	5	739	c.499G>C	c.(499-501)GAT>CAT	p.D167H	uc011kjm.1_5'Flank	NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	544											0						GTGGGCGCGAGATCGCGCCCA	0.582													9	59					0	0	0	0	C	99917593	C	C	99917593	3	2	252	1	0	0	0	0	1	0	0	0	15096	942	33	2	1668	2	SPDYE3	7	99917593	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	7722251	99917593	59221070	114	46105											
MUC17	140453	broad.mit.edu	37	chr7	100686712	100686712	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagctcccctcacatatgtGaccatgtctactgcccccag	8	9	7	17	0	2	1	1	1	1	0	3	1	3	1	5	0	3	2	5	0	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:100686712G>A	uc003uxp.1	+	3	12068	c.12015G>A	c.(12013-12015)GTG>GTA	p.V4005V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4005	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCACATATGTGACCATGTCTA	0.488													11	318					0	0	0	0	A	100686712	A	A	100686712	2	1	252	1	0	0	0	0	0	0	0	1	10027	1277	45	2		2	MUC17	7	100686712	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	769119	100686712	58451951	115	46106											
MUC17	140453	broad.mit.edu	37	chr7	100686943	100686943	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaacctctgcctcctccacGactgtgaaccctgaggctgt	8	9	8	16	1	1	2	0	2	1	0	3	3	3	2	5	1	3	1	5	1	2	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:100686943G>A	uc003uxp.1	+	3	12299	c.12246G>A	c.(12244-12246)ACG>ACA	p.T4082T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4082	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTCCTCCACGACTGTGAACC	0.572													40	280					0	0	0	0	A	100686943	A	A	100686943	2	1	252	1	0	0	0	0	0	0	0	1	10027	1045	37	1		1	MUC17	7	100686943	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	231	100686943	58451720	116	46107											
PLOD3	8985	broad.mit.edu	37	chr7	100855553	100855553	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catggccatgtccctggcctCgcctgggctcagagcctcct	4	9	11	17	1	1	1	1	0	0	1	4	1	3	1	6	3	1	1	6	3	0	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:100855553C>T	uc003uyd.2	-	10	1564	c.1108G>A	c.(1108-1110)GAG>AAG	p.E370K	PLOD3_uc010lhs.2_5'UTR	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	370					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	TCCCTGGCCTCGCCTGGGCTC	0.667													23	165					0	0	0	0	T	100855553	T	T	100855553	3	4	252	1	0	0	0	0	1	0	0	0	12158	893	31	1	1148	1	PLOD3	7	100855553	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	168610	100855553	58283110	117	46108											
PLOD3	8985	broad.mit.edu	37	chr7	100859523	100859523	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactcgggccagcagaagctCtctgcagagaagagcaggcg	11	4	14	12	2	1	3	0	0	1	3	3	4	1	3	1	2	4	4	1	2	2	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:100859523C>G	uc003uyd.2	-	4	879	c.423G>C	c.(421-423)GAG>GAC	p.E141D	ZNHIT1_uc003uye.2_5'Flank|ZNHIT1_uc003uyf.2_5'Flank	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	141					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	AGCAGAAGCTCTCTGCAGAGA	0.637													17	97					0	0	0	0	G	100859523	G	G	100859523	3	3	252	1	0	0	0	0	1	0	0	0	12158	912	32	2	1857	2	PLOD3	7	100859523	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3970	100859523	58279140	118	46109											
KIAA1549	57670	broad.mit.edu	37	chr7	138602191	138602191	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtagacgcttcaacaaactcGagagaatcagaagggaagct	16	6	11	8	2	2	3	2	0	0	3	3	6	2	4	0	1	3	3	0	1	6	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr7:138602191G>A	uc011kql.1	-	2	2230	c.2181C>T	c.(2179-2181)CTC>CTT	p.L727L	KIAA1549_uc003vuk.3_Silent_p.L677L|KIAA1549_uc011kqj.1_Silent_p.L727L	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	727	Ser-rich.					integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						CAACAAACTCGAGAGAATCAG	0.468			O	BRAF	pilocytic astrocytoma								4	26					0	0	0	0	A	138602191	A	A	138602191	2	1	252	1	0	0	0	0	0	0	0	1	8283	1045	37	1		1	KIAA1549	7	138602191	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	37742668	138602191	20536472	119	46110											
ASH2L	9070	broad.mit.edu	37	chr8	37964677	37964677	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggctgacacatttggcataGatacctcgtgagtacttttc	9	13	9	10	2	0	3	0	2	0	1	2	3	0	3	1	2	2	3	1	2	3	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:37964677G>C	uc003xkt.3	+	3	452	c.394G>C	c.(394-396)GAT>CAT	p.D132H	ASH2L_uc011lbk.1_Intron|ASH2L_uc003xku.3_Missense_Mutation_p.D38H|ASH2L_uc010lwa.2_Missense_Mutation_p.D38H	NM_004674	NP_004665	Q9UBL3	ASH2L_HUMAN	ash2-like isoform a	132	C4-type.				hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				ATTTGGCATAGATACCTCGTG	0.433													12	228					0	0	0	0	C	37964677	C	C	37964677	3	2	252	1	0	0	0	0	1	0	0	0	1044	942	33	2	404	2	ASH2L	8	37964677	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08		37964677	108399345	120	46111											
WHSC1L1	54904	broad.mit.edu	37	chr8	38172976	38172976	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcattccagtgcctcttctCgacaaacttgaatccatgga	10	12	6	13	1	3	1	1	1	2	0	6	3	5	2	3	1	2	0	3	1	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:38172976C>T	uc003xli.2	-	11	2591	c.2073G>A	c.(2071-2073)TCG>TCA	p.S691S	WHSC1L1_uc011lbm.1_Silent_p.S691S|WHSC1L1_uc010lwe.2_Silent_p.S691S	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	691					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TGCCTCTTCTCGACAAACTTG	0.428			T	NUP98	AML								29	271					0	0	0	0	T	38172976	T	T	38172976	2	4	252	1	0	0	0	0	0	0	0	1	17431	871	31	1		1	WHSC1L1	8	38172976	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	208299	38172976	108191046	121	46112											
CEBPD	1052	broad.mit.edu	37	chr8	48650425	48650425	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccgccttgtgattgctgttGaagaggtcggcgaagagctc	7	10	14	10	3	0	4	0	2	0	2	2	5	0	4	2	2	2	3	2	2	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:48650425G>A	uc003xqh.1	-	1	302	c.258C>T	c.(256-258)TTC>TTT	p.F86F	KIAA0146_uc003xqg.1_Intron	NM_005195	NP_005186	P49716	CEBPD_HUMAN	CCAAT/enhancer binding protein delta	86					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(86;0.0782)|Lung NSC(58;0.00363)|all_epithelial(80;0.0042)|all_lung(54;0.00914)				GATTGCTGTTGAAGAGGTCGG	0.612													5	5					0	0	0	0	A	48650425	A	A	48650425	2	1	252	1	0	0	0	0	0	0	0	1	3216	1281	45	2		2	CEBPD	8	48650425	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	10477449	48650425	97713597	122	46113											
PXDNL	137902	broad.mit.edu	37	chr8	52320812	52320812	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taagccgcggagaagagcctCtgggtcagctcaggactgag	10	6	15	10	2	3	3	2	1	1	2	3	5	3	4	2	3	3	1	2	3	2	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:52320812C>G	uc003xqu.3	-	17	3473	c.3372G>C	c.(3370-3372)CAG>CAC	p.Q1124H	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1124					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AGAAGAGCCTCTGGGTCAGCT	0.577													11	64					0	0	0	0	G	52320812	G	G	52320812	3	3	252	1	0	0	0	0	1	0	0	0	12913	912	32	2	1047	2	PXDNL	8	52320812	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3670387	52320812	94043210	123	46114											
NSMAF	8439	broad.mit.edu	37	chr8	59511881	59511881	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgttcagacacataattgcTttccaatgcatctttgctct	9	16	6	10	0	3	1	1	0	2	1	4	1	4	1	1	0	3	4	1	0	2	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:59511881T>C	uc003xtt.2	-	19	1709	c.1495A>G	c.(1495-1497)AGC>GGC	p.S499G	NSMAF_uc011lee.1_Missense_Mutation_p.S530G	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	499	BEACH.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				ACATAATTGCTTTCCAATGCA	0.393													49	73					0	0	0	0	C	59511881	C	C	59511881	3	2	252	1	0	0	0	0	1	0	0	0	10728	1609	56	5	1310	5	NSMAF	8	59511881	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	7191069	59511881	86852141	124	46115											
CSPP1	79848	broad.mit.edu	37	chr8	68071344	68071344	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttcagcactactgtgaaaGagacaatttgattggggaag	14	10	11	6	0	1	3	1	2	0	1	1	5	1	4	0	2	2	1	0	2	4	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:68071344G>C	uc003xxi.2	+	21	2631	c.2600G>C	c.(2599-2601)AGA>ACA	p.R867T	CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.R832T|CSPP1_uc003xxk.2_Missense_Mutation_p.R487T	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	867						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TACTGTGAAAGAGACAATTTG	0.279													8	107					0	0	0	0	C	68071344	C	C	68071344	3	2	252	1	0	0	0	0	1	0	0	0	3979	942	33	2	2682	2	CSPP1	8	68071344	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	8559463	68071344	78292678	125	46116											
FAM92A1	137392	broad.mit.edu	37	chr8	94740469	94740469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagaaaggatcaacaagcaGaagatgatgaggatgacgag	19	5	13	4	1	1	6	1	3	0	3	1	9	1	8	0	2	2	1	0	2	5	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:94740469G>A	uc010maq.2	+	8	917	c.814G>A	c.(814-816)GAA>AAA	p.E272K	FAM92A1_uc003yfv.3_RNA|FAM92A1_uc003yfx.3_RNA|FAM92A1_uc003yfw.3_RNA|FAM92A1_uc010mar.2_Missense_Mutation_p.E79K	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	272											0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TCAACAAGCAGAAGATGATGA	0.279													5	46					0	0	0	0	A	94740469	A	A	94740469	3	1	252	1	0	0	0	0	1	0	0	0	5684	943	33	2	844	2	FAM92A1	8	94740469	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	26669125	94740469	51623553	126	46117											
KIAA1429	25962	broad.mit.edu	37	chr8	95550492	95550492	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctagcaggtacataccttcCcaacctatcgaaaacagggg	13	7	8	13	1	0	0	0	0	0	0	2	1	1	0	4	3	5	2	4	3	7	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:95550492C>G	uc003ygo.1	-	3	275	c.262G>C	c.(262-264)GGA>CGA	p.G88R	KIAA1429_uc003ygp.2_Missense_Mutation_p.G88R	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	88					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ACATACCTTCCCAACCTATCG	0.368													21	38					0	0	0	0	G	95550492	G	G	95550492	3	3	252	1	0	0	0	0	1	0	0	0	8270	632	22	4	5318	4	KIAA1429	8	95550492	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	810023	95550492	50813530	127	46118											
MTDH	92140	broad.mit.edu	37	chr8	98735238	98735238	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaatccaagtcaaataccaaGcaaaatagtgtgcctccttc	16	9	5	11	0	1	0	1	0	0	0	4	0	3	0	4	0	3	1	4	0	8	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:98735238G>C	uc003yhz.2	+	11	1981	c.1653G>C	c.(1651-1653)AAG>AAC	p.K551N	MTDH_uc010mbf.2_RNA	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	551	Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			CAAATACCAAGCAAAATAGTG	0.373													32	95					0	0	0	0	C	98735238	C	C	98735238	3	2	252	1	0	0	0	0	1	0	0	0	9970	962	34	4	1695	4	MTDH	8	98735238	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3184746	98735238	47628784	128	46119											
VPS13B	157680	broad.mit.edu	37	chr8	100847876	100847876	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gactgcaagaccaaagacttActtccaagcctacttttgag	13	10	7	11	0	0	3	0	1	0	2	1	4	1	3	3	0	4	1	3	0	5	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:100847876A>G	uc003yiv.2	+	54	10038	c.9927A>G	c.(9925-9927)TTA>TTG	p.L3309L	VPS13B_uc003yiw.2_Silent_p.L3284L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3309					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCAAAGACTTACTTCCAAGCC	0.428													21	48					0	0	0	0	G	100847876	G	G	100847876	2	3	252	1	0	0	0	0	0	0	0	1	17258	388	14	5		5	VPS13B	8	100847876	Silent	SNP	A	TCGA-CV-7414-01A-11D-2078-08	2112638	100847876	45516146	129	46120											
PABPC1	26986	broad.mit.edu	37	chr8	101733737	101733737	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctgaacttctcgtagagcatCgcctcggtcacgtcggggtg	6	10	13	12	5	2	2	1	1	1	1	6	2	2	2	1	3	2	2	1	3	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:101733737C>G	uc003yjs.1	-	1	579	c.75G>C	c.(73-75)GCG>GCC	p.A25A	PABPC1_uc011lhc.1_Silent_p.A25A|PABPC1_uc011lhd.1_Intron|PABPC1_uc003yjt.1_Silent_p.A25A|PABPC1_uc003yju.2_RNA	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	25	RRM 1.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CGTAGAGCATCGCCTCGGTCA	0.672													7	43					0	0	0	0	G	101733737	G	G	101733737	2	3	252	1	0	0	0	0	0	0	0	1	11417	871	31	3		3	PABPC1	8	101733737	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	885861	101733737	44630285	130	46121											
KLF10	7071	broad.mit.edu	37	chr8	103664280	103664280	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtcagaaggactgtaaggtgGagtcaaacactaaagaaaag	18	6	12	5	0	2	2	2	0	0	2	2	4	2	4	0	3	1	1	0	3	7	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:103664280G>C	uc011lhk.1	-	3	434	c.280C>G	c.(280-282)CCA>GCA	p.P94A	KLF10_uc011lhj.1_Missense_Mutation_p.P83A	NM_005655	NP_005646	Q13118	KLF10_HUMAN	Kruppel-like factor 10 isoform a	94					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			CTGTAAGGTGGAGTCAAACAC	0.343											OREG0018913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	32					0	0	0	0	C	103664280	C	C	103664280	3	2	252	1	0	0	0	0	1	0	0	0	8377	1174	41	2	1170	2	KLF10	8	103664280	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1930543	103664280	42699742	131	46122											
CSMD3	114788	broad.mit.edu	37	chr8	114031357	114031357	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgtaacaaaatgcagtctGagccagtttttgttgctgat	10	15	9	7	0	2	2	0	2	2	0	2	2	2	2	1	0	4	5	1	0	3	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:114031357G>A	uc003ynu.2	-	6	1128	c.969C>T	c.(967-969)CTC>CTT	p.L323L	CSMD3_uc003ynt.2_Silent_p.L283L|CSMD3_uc011lhx.1_Silent_p.L323L|CSMD3_uc010mcx.1_Silent_p.L323L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	323	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATGCAGTCTGAGCCAGTTTT	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	115					0	0	0	0	A	114031357	A	A	114031357	2	1	252	1	0	0	0	0	0	0	0	1	3963	1277	45	2		2	CSMD3	8	114031357	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	10367077	114031357	32332665	132	46123											
ZC3H3	23144	broad.mit.edu	37	chr8	144621302	144621302	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctgagggtcccgggggccGattcacgagggagtatttct	6	10	16	9	3	3	1	1	1	2	0	4	4	4	2	2	4	0	1	2	4	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:144621302G>A	uc003yyd.2	-	2	264	c.235C>T	c.(235-237)CGG>TGG	p.R79W		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	79					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CCCGGGGGCCGATTCACGAGG	0.672													62	46					0	0	0	0	A	144621302	A	A	144621302	3	1	252	1	0	0	0	0	1	0	0	0	17636	1057	37	1	2655	1	ZC3H3	8	144621302	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	30589945	144621302	1742720	133	46124											
ZNF251	90987	broad.mit.edu	37	chr8	145947498	145947498	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaccatgttttctgcacttaCgagtctctccgctgtgaact	7	14	8	12	2	2	1	0	1	2	0	4	3	3	1	2	0	3	3	2	0	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr8:145947498C>T	uc003zdv.3	-	5	1803	c.1547G>A	c.(1546-1548)CGT>CAT	p.R516H		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	516					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TCTGCACTTACGAGTCTCTCC	0.532													28	62					0	0	0	0	T	145947498	T	T	145947498	3	4	252	1	0	0	0	0	1	0	0	0	17863	536	19	1	472	1	ZNF251	8	145947498	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1326196	145947498	416524	134	46125											
CDKN2A	1029	broad.mit.edu	37	chr9	21971029	21971029	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccacgggcagacggcccCaggcatcgcgcacgtccagc	7	3	14	17	5	0	1	0	0	0	1	3	1	2	1	4	4	1	3	4	4	0	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:21971029C>T	uc003zpk.2	-	2	541	c.329G>A	c.(328-330)TGG>TAG	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.L165L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGACGGCCCCAGGCATCGCG	0.731		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			26	7					0	0	0	0	T	21971029	T	T	21971029	4	4	252	1	0	0	0	0	0	1	0	0	3176	595	21	4	149	4	CDKN2A	9	21971029	Nonsense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08		21971029	119242402	135	46126											
FAM75A6	389730	broad.mit.edu	37	chr9	43628678	43628678	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaagtctcctccaggcctctCgggcactctctaccagctgg	6	9	10	16	1	3	0	0	0	3	0	7	1	4	0	4	3	2	2	4	3	2	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:43628678C>G	uc011lrb.1	-	3	293	c.264G>C	c.(262-264)CCG>CCC	p.P88P		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	88						integral to membrane					0						CCAGGCCTCTCGGGCACTCTC	0.587													30	21					0	0	0	0	G	43628678	G	G	43628678	2	3	252	1	0	0	0	0	0	0	0	1	5654	871	31	3		3	FAM75A6	9	43628678	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	21657649	43628678	97584753	136	46127											
GNAQ	2776	broad.mit.edu	37	chr9	80537224	80537224	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacccatggatgattctcatCtgcttgataaacgtactctt	10	14	7	10	1	3	2	1	2	3	0	4	4	3	3	1	1	3	2	1	1	3	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:80537224C>T	uc004akw.2	-	2	215	c.174G>A	c.(172-174)CAG>CAA	p.Q58Q		NM_002072	NP_002063	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein),	58					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			eye(136)|skin(44)|meninges(11)|ovary(1)|kidney(1)	193						TGATTCTCATCTGCTTGATAA	0.463			Mis		uveal melanoma								66	82					0	0	0	0	T	80537224	T	T	80537224	2	4	252	1	0	0	0	0	0	0	0	1	6546	912	32	2		2	GNAQ	9	80537224	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	36908546	80537224	60676207	137	46128											
COL27A1	85301	broad.mit.edu	37	chr9	117015171	117015171	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttggcagggtcatcctggaAtgccaggtggtatggggacc	7	9	16	9	0	1	0	1	0	0	0	2	2	2	2	3	7	1	2	3	7	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:117015171A>C	uc011lxl.1	+	27	3100	c.3100A>C	c.(3100-3102)ATG>CTG	p.M1034L	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1034	Pro-rich.|Collagen-like 7.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						TCATCCTGGAATGCCAGGTGG	0.552													21	31					0	0	0	0	C	117015171	C	C	117015171	3	2	252	1	0	0	0	0	1	0	0	0	3700	101	4	5	3206	5	COL27A1	9	117015171	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	36477947	117015171	24198260	138	46129											
TNC	3371	broad.mit.edu	37	chr9	117797486	117797486	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttatatacttaaaataccttGactgtgccatccactgattc	12	15	4	10	0	0	2	0	2	0	0	2	2	1	2	3	0	3	0	3	0	6	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:117797486G>C	uc004bjj.3	-	22	6146	c.5784C>G	c.(5782-5784)GTC>GTG	p.V1928V	TNC_uc010mvf.2_Silent_p.V1655V	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1928	Fibronectin type-III 15.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						AAAATACCTTGACTGTGCCAT	0.468													8	73					0	0	0	0	C	117797486	C	C	117797486	2	2	252	1	0	0	0	0	0	0	0	1	16336	1277	45	2		2	TNC	9	117797486	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	782315	117797486	23415945	139	46130											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123169396	123169396	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccttgccagctgttccttGagcctgctctgcagagtgct	4	12	10	15	0	1	2	0	1	1	1	2	2	2	2	5	0	6	5	5	0	0	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:123169396G>C	uc004bkf.2	-	32	5038	c.4857C>G	c.(4855-4857)CTC>CTG	p.L1619L	CDK5RAP2_uc010mvi.2_Silent_p.L628L|CDK5RAP2_uc004bke.2_Silent_p.L904L|CDK5RAP2_uc004bkg.2_Intron|CDK5RAP2_uc011lxw.1_Silent_p.L884L|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Silent_p.L884L|CDK5RAP2_uc011lya.1_Silent_p.L884L|CDK5RAP2_uc004bkh.1_Silent_p.L1389L|CDK5RAP2_uc004bki.2_3'UTR	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1619					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						GCTGTTCCTTGAGCCTGCTCT	0.592													18	56					0	0	0	0	C	123169396	C	C	123169396	2	2	252	1	0	0	0	0	0	0	0	1	3161	1277	45	2		2	CDK5RAP2	9	123169396	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	5371910	123169396	18044035	140	46131											
PTGS1	5742	broad.mit.edu	37	chr9	125154519	125154519	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attgtatggagacattgatgCgttggagttctaccctggac	9	13	12	7	1	1	2	0	1	1	1	1	5	1	4	1	3	2	3	1	3	2	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:125154519C>T	uc004bmg.1	+	11	1631	c.1496C>T	c.(1495-1497)GCG>GTG	p.A499V	PTGS1_uc011lys.1_Missense_Mutation_p.A437V|PTGS1_uc010mwb.1_Missense_Mutation_p.A353V|PTGS1_uc004bmf.1_Missense_Mutation_p.A462V|PTGS1_uc004bmh.1_Missense_Mutation_p.A390V|PTGS1_uc011lyt.1_Missense_Mutation_p.A390V	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	499					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	GACATTGATGCGTTGGAGTTC	0.468													5	57					0	0	0	0	T	125154519	T	T	125154519	3	4	252	1	0	0	0	0	1	0	0	0	12818	768	27	1	1538	1	PTGS1	9	125154519	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1985123	125154519	16058912	141	46132											
GOLGA2	2801	broad.mit.edu	37	chr9	131022404	131022404	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcagctcgcccagcttctttCccagctccctcttgacgtgc	4	11	8	18	2	2	1	0	1	2	0	5	1	4	1	3	0	4	4	3	0	0	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:131022404C>G	uc011maw.1	-	18	1755	c.1742G>C	c.(1741-1743)GGA>GCA	p.G581A	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004buh.2_Missense_Mutation_p.G54A	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	581	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						CAGCTTCTTTCCCAGCTCCCT	0.612													7	124					0	0	0	0	G	131022404	G	G	131022404	3	3	252	1	0	0	0	0	1	0	0	0	6589	855	30	2	1302	2	GOLGA2	9	131022404	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5867885	131022404	10191027	142	46133											
NUP188	23511	broad.mit.edu	37	chr9	131745290	131745290	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcccatcacatctcgcatCtacatgctgctgcagcggtg	7	10	9	15	2	3	0	1	0	2	0	4	0	3	0	1	1	6	4	1	1	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:131745290C>G	uc004bws.1	+	17	1801	c.1779C>G	c.(1777-1779)ATC>ATG	p.I593M	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	593					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						CATCTCGCATCTACATGCTGC	0.532													40	65					0	0	0	0	G	131745290	G	G	131745290	3	3	252	1	0	0	0	0	1	0	0	0	10812	903	32	2	1845	2	NUP188	9	131745290	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	722886	131745290	9468141	143	46134											
SETX	23064	broad.mit.edu	37	chr9	135204799	135204799	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcccctttctggaccatttCttgaagtacagtcctttggt	7	16	7	11	0	2	1	0	1	2	0	4	2	4	2	4	2	1	1	4	2	2	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr9:135204799C>G	uc004cbk.2	-	10	2369	c.2186G>C	c.(2185-2187)AGA>ACA	p.R729T	SETX_uc004cbj.2_Missense_Mutation_p.R348T|SETX_uc010mzt.2_Missense_Mutation_p.R348T	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	729					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGGACCATTTCTTGAAGTACA	0.363													9	106					0	0	0	0	G	135204799	G	G	135204799	3	3	252	1	0	0	0	0	1	0	0	0	14206	913	32	2	5915	2	SETX	9	135204799	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3459509	135204799	6008632	144	46135											
LARP4B	23185	broad.mit.edu	37	chr10	882344	882344	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggagaaattacttactTccacgggggtagattcagat	13	10	11	7	1	1	4	1	0	0	4	2	5	2	4	1	3	2	1	1	3	4	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:882344T>A	uc001ifs.1	-	7	790	c.749A>T	c.(748-750)GAA>GTA	p.E250V		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	250	RRM.						nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						ATTACTTACTTCCACGGGGGT	0.363													15	33					0	0	0	0	A	882344	A	A	882344	3	1	252	1	0	0	0	0	1	0	0	0	8671	1797	62	5	1511	5	LARP4B	10	882344	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08		882344	134652403	145	46136											
SLC39A12	221074	broad.mit.edu	37	chr10	18276458	18276458	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctcacactgggctccatgCtggggacagcgctggtcctt	5	11	12	13	1	1	0	1	0	1	0	4	1	3	1	2	4	2	3	2	4	0	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:18276458C>T	uc001ipo.2	+	7	1420	c.1147C>T	c.(1147-1149)CTG>TTG	p.L383L	SLC39A12_uc001ipn.2_Silent_p.L383L|SLC39A12_uc001ipp.2_Silent_p.L383L|SLC39A12_uc010qck.1_Silent_p.L249L	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	383	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						GGGCTCCATGCTGGGGACAGC	0.557													22	40					0	0	0	0	T	18276458	T	T	18276458	2	4	252	1	0	0	0	0	0	0	0	1	14679	796	28	4		4	SLC39A12	10	18276458	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	17394114	18276458	117258289	146	46137											
PDSS1	23590	broad.mit.edu	37	chr10	27035305	27035305	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacctcgcccagcagtactGccatgaagcaataagagaga	14	6	9	12	1	0	3	0	1	0	2	1	4	0	3	3	0	5	3	3	0	5	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:27035305G>A	uc001isv.2	+	12	1197	c.1151G>A	c.(1150-1152)TGC>TAC	p.C384Y	PDSS1_uc001isw.2_3'UTR|PDSS1_uc010qdf.1_Missense_Mutation_p.C122Y	NM_014317	NP_055132	Q5T2R2	DPS1_HUMAN	prenyl diphosphate synthase, subunit 1	384					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity				0						CAGCAGTACTGCCATGAAGCA	0.423													6	49					0	0	0	0	A	27035305	A	A	27035305	3	1	252	1	0	0	0	0	1	0	0	0	11747	1319	46	4	1197	4	PDSS1	10	27035305	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	8758847	27035305	108499442	147	46138											
ZNF248	57209	broad.mit.edu	37	chr10	38121209	38121209	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gacttcttgctgaaattactCccattttcattgtaatcata	11	17	4	9	0	3	1	2	1	1	0	4	2	4	1	1	0	2	2	1	0	4	8			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:38121209C>G	uc001izd.1	-	6	1573	c.1074G>C	c.(1072-1074)GGG>GGC	p.G358G	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Silent_p.G358G	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGAAATTACTCCCATTTTCAT	0.403													29	58					0	0	0	0	G	38121209	G	G	38121209	2	3	252	1	0	0	0	0	0	0	0	1	17860	842	30	2		2	ZNF248	10	38121209	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	11085904	38121209	97413538	148	46139											
HNRNPF	3185	broad.mit.edu	37	chr10	43882509	43882509	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaactcactgtcgccgtatCtgtggtcatacattccggag	8	12	10	11	3	3	1	2	1	1	0	5	2	4	2	2	2	2	1	2	2	3	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:43882509C>T	uc009xmh.1	-	3	1311	c.824G>A	c.(823-825)AGA>AAA	p.R275K	HNRNPF_uc001jar.2_Missense_Mutation_p.R275K|HNRNPF_uc001jas.2_Missense_Mutation_p.R275K|HNRNPF_uc001jat.2_Missense_Mutation_p.R275K|HNRNPF_uc001jav.2_Missense_Mutation_p.R275K|HNRNPF_uc001jau.2_Missense_Mutation_p.R275K|uc010qfa.1_Missense_Mutation_p.S64F	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	275					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0						GTCGCCGTATCTGTGGTCATA	0.562													16	11					0	0	0	0	T	43882509	T	T	43882509	3	4	252	1	0	0	0	0	1	0	0	0	7304	913	32	2	427	2	HNRNPF	10	43882509	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5761300	43882509	91652238	149	46140											
TMEM72	643236	broad.mit.edu	37	chr10	45430193	45430193	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgaggtgctggcctccccaGagcagtacacagacccctct	8	6	10	17	1	1	2	0	0	1	2	2	3	2	2	6	2	3	3	6	2	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:45430193G>C	uc001jbn.2	+	5	636	c.439G>C	c.(439-441)GAG>CAG	p.E147Q	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Missense_Mutation_p.E29Q	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	147						integral to membrane					0						GGCCTCCCCAGAGCAGTACAC	0.612													7	83					0	0	0	0	C	45430193	C	C	45430193	3	2	252	1	0	0	0	0	1	0	0	0	16267	943	33	2	457	2	TMEM72	10	45430193	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1547684	45430193	90104554	150	46141											
OR13A1	79290	broad.mit.edu	37	chr10	45799279	45799279	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagcagcaggggagggacctCgcagaagaaatggataatga	16	4	15	6	1	0	3	0	1	0	2	1	6	0	6	1	4	2	3	1	4	4	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:45799279C>T	uc001jcc.1	-	4	901	c.592G>A	c.(592-594)GAG>AAG	p.E198K	OR13A1_uc001jcd.1_Missense_Mutation_p.E194K	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	198	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGAGGGACCTCGCAGAAGAAA	0.567													17	23					0	0	0	0	T	45799279	T	T	45799279	3	4	252	1	0	0	0	0	1	0	0	0	10987	893	31	1	398	1	OR13A1	10	45799279	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	369086	45799279	89735468	151	46142											
FAM21C	253725	broad.mit.edu	37	chr10	46250521	46250521	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgatgatggtgatgatgatGacgactttttctcggcaccc	9	13	11	8	2	1	6	0	6	1	0	2	7	1	6	1	2	0	1	1	2	0	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:46250521G>A	uc001jcu.2	+	15	1477	c.1378G>A	c.(1378-1380)GAC>AAC	p.D460N	FAM21C_uc001jcs.1_Missense_Mutation_p.D405N|FAM21C_uc001jct.2_Missense_Mutation_p.D460N|FAM21C_uc010qfi.1_Missense_Mutation_p.D436N|FAM21C_uc010qfj.1_5'UTR|FAM21C_uc010qfk.1_5'Flank	NM_015262	NP_056077	A8K5W5	A8K5W5_HUMAN	hypothetical protein LOC253725	460										ovary(1)	1						tgatgatgatgacgaCTTTTT	0.438													10	13					0	0	0	0	A	46250521	A	A	46250521	3	1	252	1	0	0	0	0	1	0	0	0	5570	1290	45	2	1436	2	FAM21C	10	46250521	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	451242	46250521	89284226	152	46143											
LRRC18	474354	broad.mit.edu	37	chr10	50122006	50122006	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aacttggagatggagtcaggGatcttcctgataagattccg	11	11	12	7	1	2	3	1	1	1	2	4	6	4	5	2	3	1	0	2	3	2	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:50122006G>C	uc001jhd.2	-	1	275	c.195C>G	c.(193-195)ATC>ATG	p.I65M	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Missense_Mutation_p.I65M	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	65	LRR 2.					cytoplasm				ovary(1)|pancreas(1)	2						TGGAGTCAGGGATCTTCCTGA	0.527													10	22					0	0	0	0	C	50122006	C	C	50122006	3	2	252	1	0	0	0	0	1	0	0	0	9024	1164	41	2	598	2	LRRC18	10	50122006	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3871485	50122006	85412741	153	46144											
CDH23	64072	broad.mit.edu	37	chr10	73326583	73326583	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcgtcctctactccttcCagcccccctcccaattcttc	5	11	4	21	1	2	0	0	0	2	0	7	0	6	0	7	0	3	1	7	0	2	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:73326583C>T	uc001jrx.3	+	7	891	c.514C>T	c.(514-516)CAG>TAG	p.Q172*	CDH23_uc001jrw.3_Nonsense_Mutation_p.Q172*|CDH23_uc001jrv.2_Nonsense_Mutation_p.Q167*|CDH23_uc009xql.2_Nonsense_Mutation_p.Q217*	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	172	Cadherin 2.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CTACTCCTTCCAGCCCCCCTC	0.612													3	42					0	0	0	0	T	73326583	T	T	73326583	4	4	252	1	0	0	0	0	0	1	0	0	3123	595	21	4	536	4	CDH23	10	73326583	Nonsense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	23204577	73326583	62208164	154	46145											
ATAD1	84896	broad.mit.edu	37	chr10	89536107	89536107	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgatcagtatccaatccatCccagagactcataaactgag	14	9	7	11	0	2	3	2	2	0	1	5	4	5	3	3	0	1	1	3	0	4	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:89536107C>T	uc001key.1	-	5	944	c.661G>A	c.(661-663)GAT>AAT	p.D221N	ATAD1_uc010qmr.1_Missense_Mutation_p.D163N|ATAD1_uc009xth.1_RNA|ATAD1_uc001kez.1_Missense_Mutation_p.D221N	NM_032810	NP_116199	Q8NBU5	ATAD1_HUMAN	ATPase family, AAA domain containing 1	221						peroxisome	ATP binding|nucleoside-triphosphatase activity			large_intestine(1)|ovary(1)	2		all_cancers(4;6.78e-12)|Prostate(4;3.56e-12)|all_epithelial(4;5.58e-09)|Melanoma(5;0.0273)|Breast(4;0.0424)|all_hematologic(4;0.0846)|Colorectal(252;0.207)|Glioma(4;0.217)|all_neural(4;0.224)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00131)|GBM - Glioblastoma multiforme(1;1.1e-32)|Lung(2;1.4e-05)|LUSC - Lung squamous cell carcinoma(2;2.69e-05)|Colorectal(12;7.09e-05)|COAD - Colon adenocarcinoma(12;0.000261)|STAD - Stomach adenocarcinoma(243;0.235)		TCCAATCCATCCCAGAGACTC	0.403													41	31					0	0	0	0	T	89536107	T	T	89536107	3	4	252	1	0	0	0	0	1	0	0	0	1072	855	30	2	444	2	ATAD1	10	89536107	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	16209524	89536107	45998640	155	46146											
DNTT	1791	broad.mit.edu	37	chr10	98064368	98064368	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcaagatttggtcgtcttCattttggagaagaaaatggg	11	15	11	4	1	3	3	2	0	1	3	4	4	3	3	0	3	0	0	0	3	4	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:98064368C>T	uc001kmf.2	+	1	284	c.114C>T	c.(112-114)TTC>TTT	p.F38F	DNTT_uc001kmg.2_Silent_p.F38F	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	38	BRCT.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		TGGTCGTCTTCATTTTGGAGA	0.542													13	12					0	0	0	0	T	98064368	T	T	98064368	2	4	252	1	0	0	0	0	0	0	0	1	4702	825	29	2		2	DNTT	10	98064368	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	8528261	98064368	37470379	156	46147											
SMC3	9126	broad.mit.edu	37	chr10	112360248	112360248	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aattagaaggtattattactCgagtagagacttatctcaat	15	14	7	5	1	1	2	1	0	1	2	3	4	1	2	0	1	1	2	0	1	9	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:112360248C>G	uc001kze.2	+	22	2605	c.2479C>G	c.(2479-2481)CGA>GGA	p.R827G		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	827	Potential.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TATTATTACTCGAGTAGAGAC	0.328													4	86					0	0	0	0	G	112360248	G	G	112360248	3	3	252	1	0	0	0	0	1	0	0	0	14848	876	31	3	2565	3	SMC3	10	112360248	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	14295880	112360248	23174499	157	46148											
DOCK1	1793	broad.mit.edu	37	chr10	129224216	129224216	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggccgttccacgagaggatgGaggcctgtttcaaacagctg	9	8	14	10	2	1	1	1	0	0	1	2	4	2	3	3	4	2	3	3	4	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:129224216G>C	uc001ljt.2	+	47	4856	c.4792G>C	c.(4792-4794)GAG>CAG	p.E1598Q	DOCK1_uc010qun.1_Missense_Mutation_p.E1619Q|DOCK1_uc009yaq.2_Missense_Mutation_p.E593Q	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1598	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CGAGAGGATGGAGGCCTGTTT	0.507													27	93					0	0	0	0	C	129224216	C	C	129224216	3	2	252	1	0	0	0	0	1	0	0	0	4706	1175	41	2	4978	2	DOCK1	10	129224216	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	16863968	129224216	6310531	158	46149											
CYP2E1	1571	broad.mit.edu	37	chr10	135346344	135346344	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caactgtccccgggacctcaCcgactgcctgctcgtggaaa	8	7	10	16	3	1	0	1	0	0	0	3	3	2	2	5	2	3	1	5	2	2	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:135346344C>G	uc001lnj.1	+	5	830	c.797C>G	c.(796-798)ACC>AGC	p.T266S	CYP2E1_uc001lnk.1_Missense_Mutation_p.T129S|CYP2E1_uc009ybl.1_Missense_Mutation_p.T67S|CYP2E1_uc009ybm.1_5'UTR|CYP2E1_uc001lnl.1_Missense_Mutation_p.T67S	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	266					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	CGGGACCTCACCGACTGCCTG	0.512									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				18	24					0	0	0	0	G	135346344	G	G	135346344	3	3	252	1	0	0	0	0	1	0	0	0	4187	507	18	4	815	4	CYP2E1	10	135346344	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	6122128	135346344	188403	159	46150											
SYCE1	93426	broad.mit.edu	37	chr10	135370596	135370596	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtctctgtttgttcttctCttcttcaatctgcaagttca	5	20	5	11	0	7	0	2	0	5	0	9	0	7	0	0	0	1	4	0	0	2	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr10:135370596C>G	uc001lno.2	-	7	544	c.439G>C	c.(439-441)GAG>CAG	p.E147Q	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Missense_Mutation_p.E19Q|SYCE1_uc009ybn.2_Missense_Mutation_p.E147Q|SYCE1_uc001lnn.2_Missense_Mutation_p.E111Q	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	147	Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TTGTTCTTCTCTTCTTCAATC	0.498													14	290					0	0	0	0	G	135370596	G	G	135370596	3	3	252	1	0	0	0	0	1	0	0	0	15494	922	32	2	687	2	SYCE1	10	135370596	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	24252	135370596	164151	160	46151											
ATHL1	80162	broad.mit.edu	37	chr11	294725	294725	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccagccccaccgagtcactCactgtggaccctgcctctga	7	8	8	18	1	3	1	2	1	1	0	4	3	4	2	6	1	2	0	6	1	0	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:294725C>G	uc010qvu.1	+	14	2305	c.2190C>G	c.(2188-2190)CTC>CTG	p.L730L	ATHL1_uc001lor.3_Silent_p.L482L|ATHL1_uc001lou.3_Silent_p.L305L|ATHL1_uc001lov.3_Silent_p.L191L	NM_025092	NP_079368	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1	730					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			liver(1)|central_nervous_system(1)|skin(1)	3		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCGAGTCACTCACTGTGGACC	0.627													11	178					0	0	0	0	G	294725	G	G	294725	2	3	252	1	0	0	0	0	0	0	0	1	1106	813	29	2		2	ATHL1	11	294725	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08		294725	134711791	161	46152											
SLC25A22	79751	broad.mit.edu	37	chr11	794488	794488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgaagtagccctcggagcGgacggtcttgatgaggcagt	8	7	16	10	4	1	2	0	2	1	0	2	5	1	4	2	4	2	2	2	4	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:794488G>A	uc001lri.2	-	4	514	c.172C>T	c.(172-174)CGC>TGC	p.R58C	SLC25A22_uc009yci.2_Missense_Mutation_p.R58C|SLC25A22_uc001lrj.2_Missense_Mutation_p.R58C|SLC25A22_uc009ycj.2_Missense_Mutation_p.R58C	NM_024698	NP_078974	Q9H936	GHC1_HUMAN	mitochondrial glutamate carrier 1	58	Solcar 1.					integral to membrane|mitochondrial inner membrane|nucleus	L-glutamate transmembrane transporter activity|protein binding|symporter activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	L-Glutamic Acid(DB00142)	CCCTCGGAGCGGACGGTCTTG	0.692													4	11					0	0	0	0	A	794488	A	A	794488	3	1	252	1	0	0	0	0	1	0	0	0	14549	1116	39	1	827	1	SLC25A22	11	794488	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	499763	794488	134212028	162	46153											
SYT8	90019	broad.mit.edu	37	chr11	1858629	1858629	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggccctgcagccccgcCttcgcctgcgcctgcccttg	1	9	11	20	3	0	0	0	0	0	0	1	0	0	0	7	1	5	2	7	1	0	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:1858629C>G	uc001lue.1	+	9	1302	c.1174C>G	c.(1174-1176)CTT>GTT	p.L392V	SYT8_uc001lud.2_Missense_Mutation_p.L392V|SYT8_uc001luf.1_Missense_Mutation_p.L378V|TNNI2_uc010qxc.1_5'Flank|TNNI2_uc010qxd.1_5'Flank|TNNI2_uc010qxe.1_5'Flank	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	392	Cytoplasmic (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCAGCCCCGCCTTCGCCTGCG	0.726													9	7					0	0	0	0	G	1858629	G	G	1858629	3	3	252	1	0	0	0	0	1	0	0	0	15546	681	24	4	1208	4	SYT8	11	1858629	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1064141	1858629	133147887	163	46154											
SYT9	143425	broad.mit.edu	37	chr11	7335110	7335110	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtggtggtggatcacttcCtagacttggctgatttcccc	7	13	11	10	0	1	2	1	1	0	1	3	3	3	3	3	4	0	1	3	4	2	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:7335110C>G	uc001mfe.2	+	3	1219	c.982C>G	c.(982-984)CTA>GTA	p.L328V	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	328	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GGATCACTTCCTAGACTTGGC	0.478													46	77					0	0	0	0	G	7335110	G	G	7335110	3	3	252	1	0	0	0	0	1	0	0	0	15547	680	24	4	992	4	SYT9	11	7335110	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5476481	7335110	127671406	164	46155											
NRIP3	56675	broad.mit.edu	37	chr11	9007292	9007292	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcagtccaggcggagggaGcccagtgtgatcactaggtg	8	6	18	9	1	1	1	1	1	0	0	2	3	2	3	2	5	1	1	2	5	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:9007292G>A	uc001mhg.2	-	4	642	c.528C>T	c.(526-528)GGC>GGT	p.G176G	NRIP3_uc010rbu.1_Intron	NM_020645	NP_065696	Q9NQ35	NRIP3_HUMAN	nuclear receptor interacting protein 3	176					proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)		GGCGGAGGGAGCCCAGTGTGA	0.542													34	40					0	0	0	0	A	9007292	A	A	9007292	2	1	252	1	0	0	0	0	0	0	0	1	10708	958	34	4		4	NRIP3	11	9007292	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1672182	9007292	125999224	165	46156											
CSRP3	8048	broad.mit.edu	37	chr11	19209824	19209824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcatgagccgcgactgtcGtgctgtcaagagccttcctg	7	10	11	13	3	2	2	2	1	0	1	4	3	3	2	3	0	3	1	3	0	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:19209824G>A	uc001mpk.2	-	3	257	c.140C>T	c.(139-141)ACG>ATG	p.T47M		NM_003476	NP_003467	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3	47	LIM zinc-binding 1.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding				0						CGCGACTGTCGTGCTGTCAAG	0.557													37	50					0	0	0	0	A	19209824	A	A	19209824	3	1	252	1	0	0	0	0	1	0	0	0	3986	1145	40	1	460	1	CSRP3	11	19209824	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	10202532	19209824	115796692	166	46157											
HARBI1	283254	broad.mit.edu	37	chr11	46625165	46625165	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctcatactcctcttccGggggctgttccatgggtcct	3	14	11	13	1	2	0	1	0	1	0	6	0	6	0	4	3	2	3	4	3	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:46625165G>A	uc001ncy.2	-	3	1213	c.965C>T	c.(964-966)CCG>CTG	p.P322L		NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	322						cytoplasm|nucleus	metal ion binding|nuclease activity				0						CTCCTCTTCCGGGGGCTGTTC	0.512													21	29					0	0	0	0	A	46625165	A	A	46625165	3	1	252	1	0	0	0	0	1	0	0	0	6997	1116	39	1	88	1	HARBI1	11	46625165	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	27415341	46625165	88381351	167	46158											
PTPRJ	5795	broad.mit.edu	37	chr11	48166647	48166647	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgtccttcagtcgctactCagatgctgtttccttgcccc	4	15	8	14	1	2	1	2	0	0	1	5	1	4	1	4	0	3	3	4	0	1	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:48166647C>G	uc001ngp.3	+	14	3237	c.2882C>G	c.(2881-2883)TCA>TGA	p.S961*		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	961	Extracellular (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						AGTCGCTACTCAGATGCTGTT	0.537													9	107					0	0	0	0	G	48166647	G	G	48166647	4	3	252	1	0	0	0	0	0	1	0	0	12869	838	29	2	2945	2	PTPRJ	11	48166647	Nonsense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1541482	48166647	86839869	168	46159											
OR4S2	219431	broad.mit.edu	37	chr11	55419207	55419207	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgtattttacaccattatCactcccatgttaaatcctct	10	16	3	12	0	2	0	1	0	1	0	4	0	4	0	3	0	1	3	3	0	5	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:55419207C>T	uc001nhs.1	+	1	828	c.828C>T	c.(826-828)ATC>ATT	p.I276I		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				ACACCATTATCACTCCCATGT	0.408													6	161					0	0	0	0	T	55419207	T	T	55419207	2	4	252	1	0	0	0	0	0	0	0	1	11137	816	29	2		2	OR4S2	11	55419207	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	7252560	55419207	79587309	169	46160											
AHNAK	79026	broad.mit.edu	37	chr11	62297223	62297223	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtttcccctctggagcttCaagattcacatctggaacat	10	13	7	11	0	4	1	2	0	2	1	5	3	5	3	2	2	2	2	2	2	3	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:62297223C>G	uc001ntl.2	-	5	4966	c.4666G>C	c.(4666-4668)GAA>CAA	p.E1556Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1556					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCTGGAGCTTCAAGATTCACA	0.458													54	109					0	0	0	0	G	62297223	G	G	62297223	3	3	252	1	0	0	0	0	1	0	0	0	414	835	29	2	13126	2	AHNAK	11	62297223	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	6878016	62297223	72709293	170	46161											
CATSPER1	117144	broad.mit.edu	37	chr11	65789074	65789074	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgaaggagtgggtctgcatCagcaagaagtccagcacggc	11	5	15	10	2	2	1	1	0	1	1	3	3	3	2	1	3	3	3	1	3	3	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:65789074C>G	uc001ogt.2	-	4	1722	c.1584G>C	c.(1582-1584)CTG>CTC	p.L528L		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	528	Helical; Name=Segment S3; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						GGGTCTGCATCAGCAAGAAGT	0.632													9	6					0	0	0	0	G	65789074	G	G	65789074	2	3	252	1	0	0	0	0	0	0	0	1	2699	813	29	2		2	CATSPER1	11	65789074	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3491851	65789074	69217442	171	46162											
SUV420H1	51111	broad.mit.edu	37	chr11	67941319	67941319	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattttgttctgatgagtatCtattacatggcaatatttca	11	18	6	6	0	3	2	1	2	2	0	3	2	3	2	0	1	1	3	0	1	5	8			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:67941319C>G	uc001onm.1	-	6	861	c.605G>C	c.(604-606)AGA>ACA	p.R202T	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_Missense_Mutation_p.R30T|SUV420H1_uc009ysf.2_5'UTR|SUV420H1_uc001ono.1_Missense_Mutation_p.R202T|SUV420H1_uc001onp.2_Missense_Mutation_p.R202T|SUV420H1_uc010rqa.1_Missense_Mutation_p.R179T|SUV420H1_uc001onq.2_Missense_Mutation_p.R202T	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	202	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						TGATGAGTATCTATTACATGG	0.284													22	34					0	0	0	0	G	67941319	G	G	67941319	3	3	252	1	0	0	0	0	1	0	0	0	15480	913	32	2	2084	2	SUV420H1	11	67941319	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	2152245	67941319	67065197	172	46163											
C11orf24	53838	broad.mit.edu	37	chr11	68029521	68029521	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gacatggcctccatctcaggGattgggctggtgtgaggtac	7	10	15	9	0	1	1	1	1	1	0	3	3	2	2	2	5	1	2	2	5	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:68029521G>A	uc001onr.3	-	4	1384	c.942C>T	c.(940-942)ATC>ATT	p.I314I	C11orf24_uc001ons.2_Silent_p.I314I	NM_022338	NP_071733	Q96F05	CK024_HUMAN	hypothetical protein LOC53838 precursor	314	Extracellular (Potential).|Pro-rich.					integral to membrane					0						CCATCTCAGGGATTGGGCTGG	0.667													10	34					0	0	0	0	A	68029521	A	A	68029521	2	1	252	1	0	0	0	0	0	0	0	1	1641	1164	41	2		2	C11orf24	11	68029521	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	88202	68029521	66976995	173	46164											
AQP11	282679	broad.mit.edu	37	chr11	77301533	77301533	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgagtcgacttgctcaaaGcggtcatcacagaggccgtc	9	8	11	13	4	3	1	3	0	0	1	6	3	4	1	2	2	2	1	2	2	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:77301533G>A	uc001oyj.2	+	1	854	c.496G>A	c.(496-498)GCG>ACG	p.A166T	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	166	Helical; Name=4; (Potential).					cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			CTTGCTCAAAGCGGTCATCAC	0.567													30	14					0	0	0	0	A	77301533	A	A	77301533	3	1	252	1	0	0	0	0	1	0	0	0	823	971	34	4	498	4	AQP11	11	77301533	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	9272012	77301533	57704983	174	46165											
CCDC90B	60492	broad.mit.edu	37	chr11	82985036	82985036	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctaattcaattttcattttCtaggtacaggaaagatcaca	14	15	5	7	0	5	1	3	0	2	1	5	2	5	2	0	2	1	1	0	2	5	8	rs11556842		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:82985036C>G	uc001pae.2	-	5	789	c.427_splice	c.e5-1	p.K143_splice	CCDC90B_uc001pac.2_Splice_Site_p.K42_splice|CCDC90B_uc001pad.2_Splice_Site_p.K42_splice|CCDC90B_uc001paf.2_Splice_Site_p.K134_splice	NM_021825	NP_068597	Q9GZT6	CC90B_HUMAN	coiled-coil domain containing 90B precursor							integral to membrane|mitochondrion|mitochondrion					0		Acute lymphoblastic leukemia(157;0.103)				TTTTCATTTTCTAGGTACAGG	0.284													6	5					0	0	0	0	G	82985036	G	G	82985036	5	3	252	1	0	0	0	0	0	0	1	0	2882	927	32	2	358	2	CCDC90B	11	82985036	Splice_Site	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5683503	82985036	52021480	175	46166											
KIAA1826	84437	broad.mit.edu	37	chr11	105880399	105880399	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagttgcaagcgttctcgctCaagttttaacttctctgttt	7	17	7	10	2	3	0	1	0	2	0	5	0	3	0	0	0	3	6	0	0	3	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:105880399C>G	uc001piy.2	-	3	1074	c.901G>C	c.(901-903)GAG>CAG	p.E301Q	KIAA1826_uc001piz.2_Missense_Mutation_p.E301Q	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	301	Potential.					nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		CGTTCTCGCTCAAGTTTTAAC	0.408													6	74					0	0	0	0	G	105880399	G	G	105880399	3	3	252	1	0	0	0	0	1	0	0	0	8299	835	29	2	140	2	KIAA1826	11	105880399	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	22895363	105880399	29126117	176	46167											
OR10G8	219869	broad.mit.edu	37	chr11	123900988	123900988	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgctgtcctatgtgtccaTcgtctgttccatcctgcgga	5	14	10	12	2	1	0	0	0	1	0	6	1	5	1	4	1	2	2	4	1	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr11:123900988T>C	uc001pzp.1	+	1	659	c.659T>C	c.(658-660)ATC>ACC	p.I220T		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	220	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TATGTGTCCATCGTCTGTTCC	0.542													29	11					0	0	0	0	C	123900988	C	C	123900988	3	2	252	1	0	0	0	0	1	0	0	0	10957	1435	50	5	661	5	OR10G8	11	123900988	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	18020589	123900988	11105528	177	46168											
DCP1B	196513	broad.mit.edu	37	chr12	2061703	2061703	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggccaaggctggccggttaGaggcatgcagctgctgctcc	6	7	15	13	2	0	1	0	0	0	1	1	1	1	1	3	5	4	7	3	5	2	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:2061703G>C	uc001qjx.1	-	7	1483	c.1403C>G	c.(1402-1404)TCT>TGT	p.S468C	DCP1B_uc010sdy.1_Missense_Mutation_p.S366C	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	468					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			TGGCCGGTTAGAGGCATGCAG	0.537													6	67					0	0	0	0	C	2061703	C	C	2061703	3	2	252	1	0	0	0	0	1	0	0	0	4316	942	33	2	462	2	DCP1B	12	2061703	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08		2061703	131790192	178	46169											
TAS2R46	259292	broad.mit.edu	37	chr12	11214516	11214516	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtatcaccagaacaacactCttaactctcctctttaagtg	13	12	4	12	0	4	1	1	0	3	1	5	1	4	1	2	0	3	1	2	0	5	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:11214516C>T	uc001qzp.1	-	1	378	c.378G>A	c.(376-378)AAG>AAA	p.K126K	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176887	NP_795368	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	126	Cytoplasmic (Potential).				sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		GAACAACACTCTTAACTCTCC	0.348													33	59					0	0	0	0	T	11214516	T	T	11214516	2	4	252	1	0	0	0	0	0	0	0	1	15648	912	32	2		2	TAS2R46	12	11214516	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	9152813	11214516	122637379	179	46170											
GRIN2B	2904	broad.mit.edu	37	chr12	13764753	13764753	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acgatgagcagcatcacaaaCatcatcacccatacgtcagc	15	6	6	14	2	4	1	4	1	0	0	4	2	4	1	1	0	5	2	1	0	2	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:13764753C>T	uc001rbt.2	-	8	1865	c.1686G>A	c.(1684-1686)ATG>ATA	p.M562I		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	562	Helical; (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCATCACAAACATCATCACCC	0.478													7	67					0	0	0	0	T	13764753	T	T	13764753	3	4	252	1	0	0	0	0	1	0	0	0	6819	478	17	4	2792	4	GRIN2B	12	13764753	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	2550237	13764753	120087142	180	46171											
SLC38A2	54407	broad.mit.edu	37	chr12	46760703	46760703	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaaaggcaactcatatttCactatgaagaggtagcttga	15	10	8	8	0	2	3	2	2	0	1	2	3	2	3	1	2	2	3	1	2	6	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:46760703C>T	uc001rpg.2	-	7	947	c.507G>A	c.(505-507)GTG>GTA	p.V169V	SLC38A2_uc010sli.1_5'Flank|SLC38A2_uc001rph.2_Silent_p.V69V	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	169	Helical; (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		ACTCATATTTCACTATGAAGA	0.388													14	37					0	0	0	0	T	46760703	T	T	46760703	2	4	252	1	0	0	0	0	0	0	0	1	14668	813	29	2		2	SLC38A2	12	46760703	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	32995950	46760703	87091192	181	46172											
GPD1	2819	broad.mit.edu	37	chr12	50500130	50500130	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagtgattggggagcgcctCggcatccccatgagtgtgct	7	9	15	10	2	0	2	0	2	0	0	2	4	1	3	3	3	2	2	3	3	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:50500130C>T	uc001rvz.2	+	4	453	c.420C>T	c.(418-420)CTC>CTT	p.L140L	GPD1_uc001rwa.2_Silent_p.L117L	NM_005276	NP_005267	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	140					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity				0					NADH(DB00157)	GGGAGCGCCTCGGCATCCCCA	0.617													11	10					0	0	0	0	T	50500130	T	T	50500130	2	4	252	1	0	0	0	0	0	0	0	1	6642	871	31	1		1	GPD1	12	50500130	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3739427	50500130	83351765	182	46173											
TARBP2	6895	broad.mit.edu	37	chr12	53899914	53899914	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccctgcagtacctcaagatCatggcaggcagcaagtgaag	12	6	12	11	0	2	2	2	1	0	1	2	2	2	2	2	2	3	5	2	2	4	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:53899914C>T	uc001sdo.2	+	9	1571	c.1083C>T	c.(1081-1083)ATC>ATT	p.I361I	TARBP2_uc001sdp.2_Silent_p.I340I|TARBP2_uc001sdq.2_Silent_p.I217I|TARBP2_uc001sdr.2_Silent_p.I217I|TARBP2_uc001sds.2_3'UTR|TARBP2_uc001sdt.2_Silent_p.I340I|TARBP2_uc001sdu.2_Silent_p.I217I|TARBP2_uc001sdv.2_RNA	NM_134323	NP_599150	Q15633	TRBP2_HUMAN	TAR RNA binding protein 2 isoform a	361	Sufficient for interaction with DICER1.|DRBM 3.|Sufficient for interaction with PRKRA.				miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)	1						ACCTCAAGATCATGGCAGGCA	0.617													7	21					0	0	0	0	T	53899914	T	T	53899914	2	4	252	1	0	0	0	0	0	0	0	1	15622	816	29	2		2	TARBP2	12	53899914	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3399784	53899914	79951981	183	46174											
HOXC13	3229	broad.mit.edu	37	chr12	54332775	54332775	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgcggcggagagcggcatcGgcggcggcggcggaggagga	6	1	24	10	9	0	1	0	0	0	1	1	5	0	4	0	10	1	1	0	10	0	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:54332775G>A	uc001sei.2	+	1	200	c.85G>A	c.(85-87)GGC>AGC	p.G29S	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	29	Gly-rich.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						gagcggcatcggcggcggcgg	0.493			T	NUP98	AML								5	5					0	0	0	0	A	54332775	A	A	54332775	3	1	252	1	0	0	0	0	1	0	0	0	7351	1116	39	1	87	1	HOXC13	12	54332775	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	432861	54332775	79519120	184	46175											
MYO1A	4640	broad.mit.edu	37	chr12	57430774	57430774	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggatctgactctttcgcatCagttggtagtgggtgcggca	7	12	14	8	2	3	1	1	1	2	0	4	2	3	2	0	4	1	4	0	4	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:57430774C>T	uc001smw.3	-	20	2400	c.2157G>A	c.(2155-2157)CTG>CTA	p.L719L	MYO1A_uc010sqz.1_Silent_p.L557L|MYO1A_uc009zpd.2_Silent_p.L719L	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	719	IQ 1.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						TCTTTCGCATCAGTTGGTAGT	0.522													37	64					0	0	0	0	T	57430774	T	T	57430774	2	4	252	1	0	0	0	0	0	0	0	1	10121	813	29	2		2	MYO1A	12	57430774	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3097999	57430774	76421121	185	46176											
CRADD	8738	broad.mit.edu	37	chr12	94244018	94244018	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcgggctgtggaggtggacCcctcgctgctcctgcacatg	4	9	15	13	2	0	0	0	0	0	0	2	2	1	2	3	4	3	4	3	4	0	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:94244018C>T	uc001tda.2	+	3	675	c.571C>T	c.(571-573)CCC>TCC	p.P191S	CRADD_uc010sur.1_Intron|CRADD_uc010sus.1_Intron	NM_003805	NP_003796	P78560	CRADD_HUMAN	CASP2 and RIPK1 domain containing adaptor with	191					apoptosis|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|signal transduction	intracellular	death domain binding|protease binding|protein binding, bridging			ovary(1)	1						GGAGGTGGACCCCTCGCTGCT	0.632													11	26					0	0	0	0	T	94244018	T	T	94244018	3	4	252	1	0	0	0	0	1	0	0	0	3860	623	22	4	577	4	CRADD	12	94244018	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	36813244	94244018	39607877	186	46177											
CCDC63	160762	broad.mit.edu	37	chr12	111318961	111318961	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgccatgaaagaccgccaGaagaaggacacctctcagta	14	5	10	12	1	1	4	1	1	1	3	2	5	1	5	4	1	1	2	4	1	4	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:111318961G>A	uc001trv.1	+	7	909	c.714G>A	c.(712-714)CAG>CAA	p.Q238Q	CCDC63_uc009zvt.1_Missense_Mutation_p.E93K|CCDC63_uc010sye.1_Silent_p.Q198Q|CCDC63_uc001trw.1_Silent_p.Q153Q	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	238	Potential.									skin(6)|ovary(1)|pancreas(1)	8						AAGACCGCCAGAAGAAGGACA	0.557													3	21					0	0	0	0	A	111318961	A	A	111318961	2	1	252	1	0	0	0	0	0	0	0	1	2847	933	33	2		2	CCDC63	12	111318961	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	17074943	111318961	22532934	187	46178											
KSR2	283455	broad.mit.edu	37	chr12	117968797	117968797	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggggcgcccgggtcggcGtctccggcaccggcaccaca	4	4	15	18	6	1	0	0	0	1	0	3	0	1	0	5	6	0	2	5	6	0	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:117968797G>A	uc001two.2	-	12	1719	c.1664C>T	c.(1663-1665)ACG>ATG	p.T555M		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	584					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCGGGTCGGCGTCTCCGGCAC	0.562													45	72					0	0	0	0	A	117968797	A	A	117968797	3	1	252	1	0	0	0	0	1	0	0	0	8622	1145	40	1	1137	1	KSR2	12	117968797	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	6649836	117968797	15883098	188	46179											
SRRM4	84530	broad.mit.edu	37	chr12	119568510	119568510	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggccggtcccctgaggaaggGcagaagtcccgccgaaggca	9	3	16	13	3	0	2	0	1	0	1	2	4	2	3	5	5	0	2	5	5	3	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:119568510G>A	uc001txa.1	+	8	934	c.642G>A	c.(640-642)GGG>GGA	p.G214G		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	214	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CTGAGGAAGGGCAGAAGTCCC	0.652													5	4					0	0	0	0	A	119568510	A	A	119568510	2	1	252	1	0	0	0	0	0	0	0	1	15237	1190	42	4		4	SRRM4	12	119568510	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1599713	119568510	14283385	189	46180											
UBC	7316	broad.mit.edu	37	chr12	125397967	125397967	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttccggcaaagatcaacctCtgctggtcaggaggaatgcc	10	9	11	11	1	3	1	2	0	1	1	4	3	4	3	3	4	3	2	3	4	3	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr12:125397967C>G	uc001ugs.3	-	2	799	c.351G>C	c.(349-351)CAG>CAC	p.Q117H	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.Q117H|UBC_uc001ugt.2_Missense_Mutation_p.Q117H|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_5'UTR	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	117	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		AGATCAACCTCTGCTGGTCAG	0.547													60	112					0	0	0	0	G	125397967	G	G	125397967	3	3	252	1	0	0	0	0	1	0	0	0	16910	912	32	2	1710	2	UBC	12	125397967	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5829457	125397967	8453928	190	46181											
USPL1	10208	broad.mit.edu	37	chr13	31233392	31233392	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggagagtccgatgaagactGatattttcgatgagtttttt	10	16	11	4	2	0	5	0	3	0	2	2	8	1	5	1	1	0	1	1	1	2	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr13:31233392G>C	uc001utc.2	+	9	3610	c.3178G>C	c.(3178-3180)GAT>CAT	p.D1060H	USPL1_uc001utd.2_Missense_Mutation_p.D731H|USPL1_uc001ute.1_Missense_Mutation_p.D731H	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	1060					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		GATGAAGACTGATATTTTCGA	0.378													7	56					0	0	0	0	C	31233392	C	C	31233392	3	2	252	1	0	0	0	0	1	0	0	0	17160	1290	45	2	3208	2	USPL1	13	31233392	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08		31233392	83936486	191	46182											
COG3	83548	broad.mit.edu	37	chr13	46092895	46092895	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgagtaattttgtttcacAgatgcagcatttaaaatcct	13	15	7	6	0	1	2	1	1	0	1	2	3	2	2	1	0	2	4	1	0	3	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr13:46092895A>G	uc001vak.2	+	18	2032	c.1931_splice	c.e18-2	p.D644_splice	COG3_uc010tfv.1_Splice_Site_p.D481_splice|COG3_uc010aci.2_Splice_Site_p.D420_splice	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3						ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		TTTGTTTCACAGATGCAGCAT	0.398													6	56					0	0	0	0	G	46092895	G	G	46092895	5	3	252	1	0	0	0	0	0	0	1	0	3674	202	7	5	1999	5	COG3	13	46092895	Splice_Site	SNP	A	TCGA-CV-7414-01A-11D-2078-08	14859503	46092895	69076983	192	46183											
LCP1	3936	broad.mit.edu	37	chr13	46732751	46732751	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgattgcttttctaaaggtCttggcaacatctgtgctttt	7	19	8	7	0	3	1	0	1	3	0	3	1	3	1	0	2	3	3	0	2	3	8			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr13:46732751C>G	uc001vaz.3	-	4	390	c.264G>C	c.(262-264)AAG>AAC	p.K88N	LCP1_uc001vba.3_Missense_Mutation_p.K88N	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	88					regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TTCTAAAGGTCTTGGCAACAT	0.398			T	BCL6	NHL 								13	38					0	0	0	0	G	46732751	G	G	46732751	3	3	252	1	0	0	0	0	1	0	0	0	8731	912	32	2	1671	2	LCP1	13	46732751	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	639856	46732751	68437127	193	46184											
ARHGEF7	8874	broad.mit.edu	37	chr13	111919901	111919901	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcatttctccaggttgccCgaagctcagcagagagtcgg	8	9	12	12	3	2	1	1	0	1	1	5	3	2	1	2	2	3	4	2	2	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr13:111919901C>G	uc001vrs.2	+	10	1270	c.1020C>G	c.(1018-1020)CCC>CCG	p.P340P	ARHGEF7_uc001vrr.2_Silent_p.P319P|ARHGEF7_uc001vrt.2_Silent_p.P290P|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_Silent_p.P162P|ARHGEF7_uc001vrv.3_Silent_p.P162P|ARHGEF7_uc001vrw.3_Silent_p.P162P|ARHGEF7_uc001vrx.3_Silent_p.P162P|ARHGEF7_uc010tjo.1_Silent_p.P237P|ARHGEF7_uc010tjp.1_Silent_p.P84P|ARHGEF7_uc010agn.1_Silent_p.P84P	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	340	DH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			CCAGGTTGCCCGAAGCTCAGC	0.453													33	130					0	0	0	0	G	111919901	G	G	111919901	2	3	252	1	0	0	0	0	0	0	0	1	911	639	23	3		3	ARHGEF7	13	111919901	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	65187150	111919901	3249977	194	46185											
ATP11A	23250	broad.mit.edu	37	chr13	113481013	113481013	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctgctcttgcagttcctCaaggcattcacggacttcct	6	14	7	14	1	4	0	2	0	2	0	6	1	6	1	2	2	2	4	2	2	1	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr13:113481013C>G	uc001vsi.3	+	12	1117	c.1029C>G	c.(1027-1029)CTC>CTG	p.L343L	ATP11A_uc001vsj.3_Silent_p.L343L|ATP11A_uc001vsm.1_Silent_p.L219L	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	343	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TGCAGTTCCTCAAGGCATTCA	0.537													19	89					0	0	0	0	G	113481013	G	G	113481013	2	3	252	1	0	0	0	0	0	0	0	1	1121	813	29	2		2	ATP11A	13	113481013	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1561112	113481013	1688865	195	46186											
RNASE10	338879	broad.mit.edu	37	chr14	20978796	20978796	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaggacaaagctgaggccActgaggagggagacggcacc	13	2	15	11	1	0	3	0	2	0	1	0	6	0	5	2	5	1	2	2	5	1	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:20978796A>T	uc010tlj.1	+	1	166	c.166A>T	c.(166-168)ACT>TCT	p.T56S	RNASE10_uc001vxp.2_Missense_Mutation_p.T84S	NM_001012975	NP_001012993	Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	56						extracellular region	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		AGCTGAGGCCACTGAGGAGGG	0.488													24	33					0	0	0	0	T	20978796	T	T	20978796	3	4	252	1	0	0	0	0	1	0	0	0	13465	159	6	5	168	5	RNASE10	14	20978796	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08		20978796	86370744	196	46187											
MMP14	4323	broad.mit.edu	37	chr14	23310776	23310776	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgctcaccccagtcactctCagcggccatcgctgccatgc	6	7	9	19	3	3	0	3	0	1	0	5	0	3	0	4	1	3	2	4	1	0	0	rs139231227		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:23310776C>T	uc001whc.2	+	2	419	c.185C>T	c.(184-186)TCA>TTA	p.S62L		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	62						extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		CAGTCACTCTCAGCGGCCATC	0.557													3	20					0	0	0	0	T	23310776	T	T	23310776	3	4	252	1	0	0	0	0	1	0	0	0	9706	838	29	2	191	2	MMP14	14	23310776	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	2331980	23310776	84038764	197	46188											
FOXG1	2290	broad.mit.edu	37	chr14	29237831	29237831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacgtcgccgcaggccccctCgaccctgccctgtgagtctt	4	8	10	19	4	1	1	0	1	1	0	3	2	1	1	5	1	1	1	5	1	0	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:29237831C>T	uc001wqe.2	+	1	1545	c.1346C>T	c.(1345-1347)TCG>TTG	p.S449L		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	449				ST -> RP (in Ref. 1; CAA52239).|QAPST -> AGPPRP (in Ref. 1; CAA52240 and 2; CAA55038).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CAGGCCCCCTCGACCCTGCCC	0.582													22	37					0	0	0	0	T	29237831	T	T	29237831	3	4	252	1	0	0	0	0	1	0	0	0	6041	893	31	1	1348	1	FOXG1	14	29237831	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5927055	29237831	78111709	198	46189											
ARHGAP5	394	broad.mit.edu	37	chr14	32560615	32560615	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcactggtacaaatgttggAtaaaactcgtagcaagccta	14	10	9	8	1	0	0	0	0	0	0	1	1	0	1	1	2	5	5	1	2	7	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:32560615A>G	uc001wrl.2	+	2	979	c.740A>G	c.(739-741)GAT>GGT	p.D247G	ARHGAP5_uc001wrm.2_Missense_Mutation_p.D247G|ARHGAP5_uc001wrn.2_Missense_Mutation_p.D247G|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	247					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CAAATGTTGGATAAAACTCGT	0.343													55	92					0	0	0	0	G	32560615	G	G	32560615	3	3	252	1	0	0	0	0	1	0	0	0	886	333	12	5	742	5	ARHGAP5	14	32560615	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	3322784	32560615	74788925	199	46190											
AKAP6	9472	broad.mit.edu	37	chr14	33004796	33004796	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttctgatcatgttgagcaaAtccatgccctccttgaaaca	11	13	6	11	0	2	3	1	3	1	0	4	3	4	3	3	0	3	2	3	0	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:33004796A>G	uc001wrq.2	+	3	531	c.361A>G	c.(361-363)ATC>GTC	p.I121V	AKAP6_uc010aml.2_Missense_Mutation_p.I118V	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	121					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TGTTGAGCAAATCCATGCCCT	0.473													30	63					0	0	0	0	G	33004796	G	G	33004796	3	3	252	1	0	0	0	0	1	0	0	0	455	101	4	5	367	5	AKAP6	14	33004796	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	444181	33004796	74344744	200	46191											
RALGAPA1	253959	broad.mit.edu	37	chr14	36103865	36103865	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcagactttccaaatgcatAaaaggatcataatctacaga	17	11	5	8	0	3	2	2	0	1	2	4	3	4	3	1	1	2	1	1	1	5	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:36103865A>G	uc001wti.2	-	32	4783	c.4392T>C	c.(4390-4392)TTT>TTC	p.F1464F	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Silent_p.F1464F|RALGAPA1_uc010tpv.1_Silent_p.F1477F|RALGAPA1_uc010tpw.1_Silent_p.F1511F	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1464	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						CCAAATGCATAAAAGGATCAT	0.423													16	35					0	0	0	0	G	36103865	G	G	36103865	2	3	252	1	0	0	0	0	0	0	0	1	13078	359	13	5		5	RALGAPA1	14	36103865	Silent	SNP	A	TCGA-CV-7414-01A-11D-2078-08	3099069	36103865	71245675	201	46192											
FRMD6	122786	broad.mit.edu	37	chr14	52156612	52156612	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaccgccgcagtgtgtgcAttttccttcccaacgatgaa	10	10	9	12	3	0	2	0	1	0	1	2	3	2	2	4	0	2	2	4	0	3	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:52156612A>G	uc001wzd.2	+	2	343	c.58A>G	c.(58-60)ATT>GTT	p.I20V	FRMD6_uc001wzb.2_Missense_Mutation_p.I20V|FRMD6_uc001wzc.2_Missense_Mutation_p.I20V	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	20	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					CAGTGTGTGCATTTTCCTTCC	0.433													23	21					0	0	0	0	G	52156612	G	G	52156612	3	3	252	1	0	0	0	0	1	0	0	0	6088	217	8	5	60	5	FRMD6	14	52156612	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	16052747	52156612	55192928	202	46193											
PTGDR	5729	broad.mit.edu	37	chr14	52741596	52741596	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttcagatctccagtatttCggatattttttcacaagatt	10	19	5	7	1	3	2	2	0	1	2	5	3	3	3	1	1	0	1	1	1	3	9			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:52741596C>T	uc001wzq.2	+	2	1096	c.994C>T	c.(994-996)CGG>TGG	p.R332W		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	332	Cytoplasmic (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	TCCAGTATTTCGGATATTTTT	0.413													11	13					0	0	0	0	T	52741596	T	T	52741596	3	4	252	1	0	0	0	0	1	0	0	0	12803	875	31	1	1000	1	PTGDR	14	52741596	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	584984	52741596	54607944	203	46194											
RTN1	6252	broad.mit.edu	37	chr14	60072193	60072193	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtacttctgaatctgctcctGagaaagggtgatctcaagct	10	12	10	9	0	3	3	1	3	3	1	5	4	4	3	1	1	3	3	1	1	4	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:60072193G>A	uc001xen.1	-	5	2214	c.2005C>T	c.(2005-2007)CAG>TAG	p.Q669*	RTN1_uc001xem.1_Nonsense_Mutation_p.Q249*|RTN1_uc001xek.1_Nonsense_Mutation_p.Q101*|RTN1_uc001xel.1_RNA|RTN1_uc010apl.1_Nonsense_Mutation_p.Q86*	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	669	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		ATCTGCTCCTGAGAAAGGGTG	0.517													13	35					0	0	0	0	A	60072193	A	A	60072193	4	1	252	1	0	0	0	0	0	1	0	0	13790	1299	45	2	345	2	RTN1	14	60072193	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	7330597	60072193	47277347	204	46195											
ZBTB1	22890	broad.mit.edu	37	chr14	64988268	64988268	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtccttcagcagctaaacAaccaaagagaatggggtttt	14	10	9	8	0	1	1	1	0	0	1	2	2	2	1	2	2	4	3	2	2	5	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:64988268A>T	uc001xhh.3	+	4	477	c.46A>T	c.(46-48)AAC>TAC	p.N16Y	ZBTB1_uc010aqg.2_Missense_Mutation_p.N16Y|ZBTB1_uc001xhi.2_Missense_Mutation_p.N16Y	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		GCAGCTAAACAACCAAAGAGA	0.393													26	42					0	0	0	0	T	64988268	T	T	64988268	3	4	252	1	0	0	0	0	1	0	0	0	17589	130	5	5	48	5	ZBTB1	14	64988268	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	4916075	64988268	42361272	205	46196											
RDH11	51109	broad.mit.edu	37	chr14	68151825	68151825	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaggagtcttgatgaaaaagGagaaaagccaccacatccat	17	6	10	8	0	1	3	0	2	1	1	2	6	2	4	3	2	1	0	3	2	4	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:68151825G>C	uc001xjv.3	-	6	851	c.761C>G	c.(760-762)TCC>TGC	p.S254C	RDH11_uc001xjw.3_Missense_Mutation_p.S241C|RDH11_uc001xjx.3_Missense_Mutation_p.S184C	NM_016026	NP_057110	Q8TC12	RDH11_HUMAN	retinol dehydrogenase 11	254	Cytoplasmic (Potential).				retinol metabolic process|steroid metabolic process	endoplasmic reticulum membrane|integral to membrane	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(1)	1				all cancers(60;0.00047)|OV - Ovarian serous cystadenocarcinoma(108;0.00206)|BRCA - Breast invasive adenocarcinoma(234;0.00924)	Vitamin A(DB00162)	GATGAAAAAGGAGAAAAGCCA	0.493													4	64					0	0	0	0	C	68151825	C	C	68151825	3	2	252	1	0	0	0	0	1	0	0	0	13255	1174	41	2	203	2	RDH11	14	68151825	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3163557	68151825	39197715	206	46197											
RDH12	145226	broad.mit.edu	37	chr14	68196078	68196078	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctgagggcctggagcccCtgagtggcaagtacttcagg	7	8	16	10	0	1	2	1	2	0	0	1	3	1	3	3	5	2	3	3	5	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:68196078C>G	uc001xjz.3	+	8	1153	c.829C>G	c.(829-831)CTG>GTG	p.L277V		NM_152443	NP_689656	Q96NR8	RDH12_HUMAN	retinol dehydrogenase 12	277					photoreceptor cell maintenance|response to stimulus|retinol metabolic process	intracellular	binding|retinol dehydrogenase activity			ovary(1)	1				all cancers(60;0.000704)|OV - Ovarian serous cystadenocarcinoma(108;0.00161)|BRCA - Breast invasive adenocarcinoma(234;0.00953)	Vitamin A(DB00162)	CCTGGAGCCCCTGAGTGGCAA	0.642													5	86					0	0	0	0	G	68196078	G	G	68196078	3	3	252	1	0	0	0	0	1	0	0	0	13256	680	24	4	851	4	RDH12	14	68196078	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	44253	68196078	39153462	207	46198											
SIPA1L1	26037	broad.mit.edu	37	chr14	72138364	72138364	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaatgtgtttcagtgggtagTtttattaacattgaggagat	11	16	12	2	0	1	2	1	1	0	1	1	4	1	2	0	2	1	3	0	2	4	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:72138364T>C	uc001xms.2	+	8	3132	c.2784T>C	c.(2782-2784)AGT>AGC	p.S928S	SIPA1L1_uc001xmt.2_Silent_p.S928S|SIPA1L1_uc001xmu.2_Silent_p.S928S|SIPA1L1_uc001xmv.2_Silent_p.S928S|SIPA1L1_uc010ttm.1_Silent_p.S403S	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	928					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CAGTGGGTAGTTTTATTAACA	0.398													53	35					0	0	0	0	C	72138364	C	C	72138364	2	2	252	1	0	0	0	0	0	0	0	1	14394	1722	60	5		5	SIPA1L1	14	72138364	Silent	SNP	T	TCGA-CV-7414-01A-11D-2078-08	3942286	72138364	35211176	208	46199											
RGS6	9628	broad.mit.edu	37	chr14	72939626	72939626	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaggaaaattttggatagtCaagaacgagccttttgggat	15	11	11	4	1	1	1	1	0	0	1	1	5	1	4	1	3	2	0	1	3	6	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:72939626C>G	uc001xna.3	+	9	1106	c.583C>G	c.(583-585)CAA>GAA	p.Q195E	RGS6_uc010ttn.1_Missense_Mutation_p.Q195E|RGS6_uc001xmx.3_Missense_Mutation_p.Q195E|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.Q195E|RGS6_uc010ttp.1_Missense_Mutation_p.Q126E|RGS6_uc001xmz.1_Missense_Mutation_p.Q56E|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	195					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		TTTGGATAGTCAAGAACGAGC	0.363													11	219					0	0	0	0	G	72939626	G	G	72939626	3	3	252	1	0	0	0	0	1	0	0	0	13374	827	29	2	613	2	RGS6	14	72939626	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	801262	72939626	34409914	209	46200											
SPTLC2	9517	broad.mit.edu	37	chr14	78028787	78028787	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctgacagtctggctcccaGaaccagtgatgcatgattca	10	10	9	12	0	2	4	1	3	1	1	4	4	4	4	3	1	2	2	3	1	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:78028787G>C	uc001xub.2	-	6	990	c.802C>G	c.(802-804)CTG>GTG	p.L268V		NM_004863	NP_004854	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base	268						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			upper_aerodigestive_tract(1)|ovary(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CTGGCTCCCAGAACCAGTGAT	0.453													32	42					0	0	0	0	C	78028787	C	C	78028787	3	2	252	1	0	0	0	0	1	0	0	0	15190	933	33	2	914	2	SPTLC2	14	78028787	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	5089161	78028787	29320753	210	46201											
TDP1	55775	broad.mit.edu	37	chr14	90446954	90446954	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctccaacctcatccatgctGactggcaccagaaaactcaa	13	7	5	16	0	2	2	2	1	0	1	4	2	4	2	5	1	3	2	5	1	4	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:90446954G>C	uc001xxy.2	+	8	1161	c.862G>C	c.(862-864)GAC>CAC	p.D288H	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.D288H|TDP1_uc010atn.2_Missense_Mutation_p.D288H|TDP1_uc001xya.2_Missense_Mutation_p.D49H|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.D288H	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	288					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		CATCCATGCTGACTGGCACCA	0.453								Repair_of_DNA-protein_crosslinks					8	42					0	0	0	0	C	90446954	C	C	90446954	3	2	252	1	0	0	0	0	1	0	0	0	15794	1290	45	2	884	2	TDP1	14	90446954	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	12418167	90446954	16902586	211	46202											
C14orf102	55051	broad.mit.edu	37	chr14	90783141	90783141	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cactttcatctgaagactctGatttcagatgactcctgttt	9	16	6	10	0	4	5	2	3	2	2	5	5	5	5	1	0	0	1	1	0	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:90783141G>C	uc001xyi.1	-	3	219	c.188C>G	c.(187-189)TCA>TGA	p.S63*	C14orf102_uc001xyj.1_Intron	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	63	Potential.						protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		TGAAGACTCTGATTTCAGATG	0.194													11	50					0	0	0	0	C	90783141	C	C	90783141	4	2	252	1	0	0	0	0	0	1	0	0	1741	1294	45	2	3354	2	C14orf102	14	90783141	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	336187	90783141	16566399	212	46203											
PRIMA1	145270	broad.mit.edu	37	chr14	94245530	94245530	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gccattacttacctggggcgGagaggagtctgggaggtggc	7	8	18	8	1	1	1	0	0	1	1	1	4	1	3	2	7	2	0	2	7	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr14:94245530G>C	uc001ybw.1	-	3	263	c.221C>G	c.(220-222)TCC>TGC	p.S74C	PRIMA1_uc001ybx.1_RNA	NM_178013	NP_821092	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1 precursor	74	Extracellular (Potential).				neurotransmitter catabolic process	cell junction|integral to membrane|synapse				large_intestine(1)|skin(1)	2		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		ACCTggggcggagaggagtct	0.368													3	7					0	0	0	0	C	94245530	C	C	94245530	3	2	252	1	0	0	0	0	1	0	0	0	12554	1174	41	2	252	2	PRIMA1	14	94245530	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3462389	94245530	13104010	213	46204											
MAGEL2	54551	broad.mit.edu	37	chr15	23890666	23890666	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcttttgaaggggccctgcGctccttcgaggaggtcctgc	4	11	14	12	2	1	1	0	1	1	0	4	3	3	2	3	4	2	1	3	4	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:23890666G>A	uc001ywj.3	-	1	510	c.415C>T	c.(415-417)CGC>TGC	p.R139C		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GGGGCCCTGCGCTCCTTCGAG	0.577													10	15					0	0	0	0	A	23890666	A	A	23890666	3	1	252	1	0	0	0	0	1	0	0	0	9242	1087	38	1	1529	1	MAGEL2	15	23890666	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08		23890666	78640726	214	46205											
C15orf2	23742	broad.mit.edu	37	chr15	24923324	24923324	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaatccaggagccaccccTcaacccaaatttggggcccc	11	7	7	16	0	1	0	1	0	0	0	2	1	2	1	7	3	2	0	7	3	4	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:24923324T>A	uc001ywo.2	+	1	2784	c.2310T>A	c.(2308-2310)CCT>CCA	p.P770P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	770					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GAGCCACCCCTCAACCCAAAT	0.562													55	112					0	0	0	0	A	24923324	A	A	24923324	2	1	252	1	0	0	0	0	0	0	0	1	1790	1538	54	5		5	C15orf2	15	24923324	Silent	SNP	T	TCGA-CV-7414-01A-11D-2078-08	1032658	24923324	77608068	215	46206											
TP53BP1	7158	broad.mit.edu	37	chr15	43708450	43708450	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatctgctgcctttgtaaGaggtgttactgcttcatagg	8	15	11	7	0	2	1	1	0	1	1	2	2	2	1	1	2	4	4	1	2	4	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:43708450G>C	uc001zrs.2	-	22	4979	c.4831C>G	c.(4831-4833)CTT>GTT	p.L1611V	TP53BP1_uc010udp.1_Missense_Mutation_p.L1611V|TP53BP1_uc001zrq.3_Missense_Mutation_p.L1616V|TP53BP1_uc001zrr.3_Missense_Mutation_p.L1616V|TP53BP1_uc010udq.1_Missense_Mutation_p.L1616V|TP53BP1_uc001zrp.2_Missense_Mutation_p.L28V	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1611					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GCCTTTGTAAGAGGTGTTACT	0.483								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					5	75					0	0	0	0	C	43708450	C	C	43708450	3	2	252	1	0	0	0	0	1	0	0	0	16450	942	33	2	1115	2	TP53BP1	15	43708450	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	18785126	43708450	58822942	216	46207											
SLC27A2	11001	broad.mit.edu	37	chr15	50494767	50494767	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagcggattgaaggcagatGatgtcatctatatcactctg	12	12	10	7	1	4	3	2	2	2	1	4	4	4	4	0	2	1	1	0	2	4	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:50494767G>A	uc001zxw.2	+	3	1004	c.772G>A	c.(772-774)GAT>AAT	p.D258N	SLC27A2_uc010bes.2_Intron|SLC27A2_uc001zxx.2_Missense_Mutation_p.D23N	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	258	Lumenal (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		GAAGGCAGATGATGTCATCTA	0.428													7	89					0	0	0	0	A	50494767	A	A	50494767	3	1	252	1	0	0	0	0	1	0	0	0	14590	1290	45	2	782	2	SLC27A2	15	50494767	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	6786317	50494767	52036625	217	46208											
TRPM7	54822	broad.mit.edu	37	chr15	50940979	50940979	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttttccacagaccattcttCtattgcctgattaaaatggt	10	16	5	10	0	2	2	0	1	2	1	3	2	3	2	3	1	1	0	3	1	3	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:50940979C>G	uc001zyt.3	-	4	490	c.226G>C	c.(226-228)GAA>CAA	p.E76Q	TRPM7_uc010bew.1_Missense_Mutation_p.E76Q	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	76	Cytoplasmic (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		GACCATTCTTCTATTGCCTGA	0.413													36	95					0	0	0	0	G	50940979	G	G	50940979	3	3	252	1	0	0	0	0	1	0	0	0	16658	922	32	2	5515	2	TRPM7	15	50940979	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	446212	50940979	51590413	218	46209											
MYO5C	55930	broad.mit.edu	37	chr15	52515861	52515861	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatgcaccactttgaagttCaaagcttcaatctccttttc	11	14	5	11	0	3	2	2	1	1	1	5	2	3	2	2	0	2	3	2	0	3	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:52515861C>T	uc010bff.2	-	29	3644	c.3507G>A	c.(3505-3507)TTG>TTA	p.L1169L	MYO5C_uc010uga.1_RNA	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	1169	Potential.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		CTTTGAAGTTCAAAGCTTCAA	0.398													19	39					0	0	0	0	T	52515861	T	T	52515861	2	4	252	1	0	0	0	0	0	0	0	1	10133	825	29	2		2	MYO5C	15	52515861	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1574882	52515861	50015531	219	46210											
WDR72	256764	broad.mit.edu	37	chr15	53994481	53994481	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttggtctaatttcgaagaGagaccatgtggatagagtaa	13	12	11	5	1	1	3	0	0	1	3	2	6	1	4	1	2	0	1	1	2	4	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:53994481G>C	uc002acj.2	-	12	1461	c.1419C>G	c.(1417-1419)CTC>CTG	p.L473L	WDR72_uc010bfi.1_Silent_p.L473L	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	473	WD 6.									lung(1)|skin(1)	2				all cancers(107;0.0511)		ATTTCGAAGAGAGACCATGTG	0.378													6	98					0	0	0	0	C	53994481	C	C	53994481	2	2	252	1	0	0	0	0	0	0	0	1	17390	929	33	2		2	WDR72	15	53994481	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1478620	53994481	48536911	220	46211											
CCPG1	9236	broad.mit.edu	37	chr15	55653023	55653023	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggataaggctttttcttcCttctccaaggatactcttaa	10	15	7	9	0	3	0	0	0	3	0	5	3	4	2	2	3	1	1	2	3	4	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:55653023C>G	uc002acv.1	-	8	1113	c.948G>C	c.(946-948)AAG>AAC	p.K316N	CCPG1_uc002acy.2_Missense_Mutation_p.K316N|CCPG1_uc002acu.1_Missense_Mutation_p.K172N|CCPG1_uc002acw.1_Missense_Mutation_p.K41N|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Missense_Mutation_p.K316N|CCPG1_uc002acz.1_Missense_Mutation_p.K316N	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	316	Potential.|Lumenal (Potential).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		CTTTTTCTTCCTTCTCCAAGG	0.358													3	54					0	0	0	0	G	55653023	G	G	55653023	3	3	252	1	0	0	0	0	1	0	0	0	2953	680	24	4	1329	4	CCPG1	15	55653023	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1658542	55653023	46878369	221	46212											
VPS13C	54832	broad.mit.edu	37	chr15	62258317	62258317	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtttttccaaaagcagtttGaaaactaggtccattcttat	13	15	6	7	0	1	1	0	1	1	0	3	1	3	1	2	1	2	3	2	1	6	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:62258317G>A	uc002agz.2	-	30	3090	c.3016C>T	c.(3016-3018)CAA>TAA	p.Q1006*	VPS13C_uc002aha.2_Nonsense_Mutation_p.Q963*|VPS13C_uc002ahb.1_Nonsense_Mutation_p.Q1006*|VPS13C_uc002ahc.1_Nonsense_Mutation_p.Q963*	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1006					protein localization					ovary(2)	2						AAAGCAGTTTGAAAACTAGGT	0.308													14	22					0	0	0	0	A	62258317	A	A	62258317	4	1	252	1	0	0	0	0	0	1	0	0	17259	1299	45	2	8497	2	VPS13C	15	62258317	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	6605294	62258317	40273075	222	46213											
TLN2	83660	broad.mit.edu	37	chr15	63017195	63017195	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcccatgaagcttgtggtccGatggaaatcgattcagctct	9	11	11	10	2	2	1	1	1	1	0	4	4	3	2	2	2	2	2	2	2	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:63017195G>C	uc002alb.3	+	24	3147	c.3147G>C	c.(3145-3147)CCG>CCC	p.P1049P		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1049	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CTTGTGGTCCGATGGAAATCG	0.493													16	24					0	0	0	0	C	63017195	C	C	63017195	2	2	252	1	0	0	0	0	0	0	0	1	16014	1045	37	3		3	TLN2	15	63017195	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	758878	63017195	39514197	223	46214											
DIS3L	115752	broad.mit.edu	37	chr15	66601162	66601162	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atggaagtgaaacagaaggaGtattcgtgattactttcaag	15	11	11	4	1	1	3	1	2	0	1	2	5	1	5	0	2	2	1	0	2	6	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:66601162G>T	uc010ujm.1	+	4	553	c.538G>T	c.(538-540)GTA>TTA	p.V180L	DIS3L_uc010ujl.1_5'UTR|DIS3L_uc002app.2_Missense_Mutation_p.V97L|DIS3L_uc002apq.2_Missense_Mutation_p.V180L|DIS3L_uc010bho.2_Missense_Mutation_p.V46L	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	180					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						AACAGAAGGAGTATTCGTGAT	0.398													33	58					1.836e-18	1.93152e-18	1	0	T	66601162	T	T	66601162	3	4	252	1	0	0	0	0	1	0	0	0	4558	1029	36	4	552	4	DIS3L	15	66601162	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3583967	66601162	35930230	224	46215											
LRRC49	54839	broad.mit.edu	37	chr15	71302304	71302304	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtttaggctaagccatttCagtatgcagaaaataaatgg	14	12	9	6	0	1	1	1	0	0	1	1	1	1	1	1	2	2	4	1	2	7	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:71302304C>T	uc002asw.2	+	13	1813	c.1566C>T	c.(1564-1566)TTC>TTT	p.F522F	LRRC49_uc002asu.2_Silent_p.F512F|LRRC49_uc002asx.2_Silent_p.F478F|LRRC49_uc010ukf.1_Silent_p.F527F|LRRC49_uc002asy.2_Silent_p.F228F|LRRC49_uc002asz.2_Silent_p.F494F	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	522						cytoplasm|microtubule				ovary(1)	1						TAAGCCATTTCAGTATGCAGA	0.318													17	22					0	0	0	0	T	71302304	T	T	71302304	2	4	252	1	0	0	0	0	0	0	0	1	9056	825	29	2		2	LRRC49	15	71302304	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	4701142	71302304	31229088	225	46216											
CCDC33	80125	broad.mit.edu	37	chr15	74536424	74536424	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaggagaccatcatggtcacCctccatggggctaccaacct	11	7	9	14	0	2	1	2	0	0	1	3	2	3	1	5	4	2	1	5	4	3	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:74536424C>T	uc002axo.2	+	2	514	c.120C>T	c.(118-120)ACC>ACT	p.T40T		NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	243	C2.						protein binding			ovary(3)|skin(2)	5						TCATGGTCACCCTCCATGGGG	0.607													20	31					0	0	0	0	T	74536424	T	T	74536424	2	4	252	1	0	0	0	0	0	0	0	1	2819	610	22	4		4	CCDC33	15	74536424	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3234120	74536424	27994968	226	46217											
MTHFS	10588	broad.mit.edu	37	chr15	80181621	80181621	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgtccttgatgatctcttCtgtctcaatttcatcttgca	8	18	5	10	0	5	2	2	2	4	0	8	2	6	2	1	0	1	1	1	0	2	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:80181621C>G	uc002bex.3	-	2	233	c.193G>C	c.(193-195)GAA>CAA	p.E65Q		NM_006441	NP_006432	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase	65					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding				0				all cancers(203;0.00467)		ATGATCTCTTCTGTCTCAATT	0.408													30	45					0	0	0	0	G	80181621	G	G	80181621	3	3	252	1	0	0	0	0	1	0	0	0	9985	922	32	2	426	2	MTHFS	15	80181621	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	5645197	80181621	22349771	227	46218											
AGBL1	123624	broad.mit.edu	37	chr15	86697725	86697725	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtgacattgattctggccagGaagaacctatcccatggcca	11	9	10	11	0	1	3	0	2	1	1	2	4	2	4	4	3	1	0	4	3	3	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr15:86697725G>C	uc002blz.1	+	3	269	c.189G>C	c.(187-189)AGG>AGC	p.R63S		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	63					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TTCTGGCCAGGAAGAACCTAT	0.478													7	15					0	0	0	0	C	86697725	C	C	86697725	3	2	252	1	0	0	0	0	1	0	0	0	375	1165	41	2	195	2	AGBL1	15	86697725	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	6516104	86697725	15833667	228	46219											
BTBD12	84464	broad.mit.edu	37	chr16	3656527	3656527	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgggacattttcttcccgCgcagcctcgagggagcactc	6	11	11	13	3	1	0	0	0	1	0	4	3	2	2	2	2	2	2	2	2	0	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:3656527C>T	uc002cvp.2	-	3	1335	c.708G>A	c.(706-708)GCG>GCA	p.A236A	BTBD12_uc002cvq.1_Silent_p.A236A	NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	236	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						TTTCTTCCCGCGCAGCCTCGA	0.512								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				69	122					0	0	0	0	T	3656527	T	T	3656527	2	4	252	1	0	0	0	0	0	0	0	1	1545	755	27	1		1	BTBD12	16	3656527	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08		3656527	86698226	229	46220											
DNAJA3	9093	broad.mit.edu	37	chr16	4491549	4491549	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcctcttcatttggagatttCcagaccgtgtttgatcagcc	7	15	8	11	1	3	3	2	1	1	2	5	4	5	3	4	1	1	1	4	1	0	4	rs141103865		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:4491549C>G	uc002cwk.2	+	4	628	c.603C>G	c.(601-603)TTC>TTG	p.F201L	DNAJA3_uc002cwl.2_Missense_Mutation_p.F201L|DNAJA3_uc010uxk.1_Missense_Mutation_p.F48L	NM_005147	NP_005138	Q96EY1	DNJA3_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 3	201					activation of caspase activity|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of cell proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|neuromuscular junction development|positive regulation of apoptosis|positive regulation of protein ubiquitination|protein folding|protein folding|protein stabilization|response to heat|response to interferon-gamma	cytosol|mitochondrial matrix|mitochondrial nucleoid|nucleus	ATP binding|heat shock protein binding|interferon-gamma receptor binding|metal ion binding|NF-kappaB binding|protein kinase binding			ovary(2)|breast(2)	4						TTGGAGATTTCCAGACCGTGT	0.443													14	40					0	0	0	0	G	4491549	G	G	4491549	3	3	252	1	0	0	0	0	1	0	0	0	4635	854	30	2	617	2	DNAJA3	16	4491549	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	835022	4491549	85863204	230	46221											
NAGPA	51172	broad.mit.edu	37	chr16	5081854	5081854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctgcacaaatgggttctCagtgtccagcacctcctcct	8	10	8	15	0	1	0	1	0	1	0	5	0	4	0	4	1	3	4	4	1	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:5081854C>T	uc002cyg.2	-	3	595	c.574G>A	c.(574-576)GAG>AAG	p.E192K	ALG1_uc002cyj.2_5'Flank|NAGPA_uc010buc.2_5'Flank|NAGPA_uc002cyf.2_Missense_Mutation_p.E50K|NAGPA_uc002cyh.2_RNA|NAGPA_uc002cyi.2_Intron|NAGPA_uc010uxx.1_3'UTR	NM_016256	NP_057340	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester	192	Lumenal (Potential).				carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity				0					N-Acetyl-D-glucosamine(DB00141)	AATGGGTTCTCAGTGTCCAGC	0.557													8	93					0	0	0	0	T	5081854	T	T	5081854	3	4	252	1	0	0	0	0	1	0	0	0	10197	835	29	2	1005	2	NAGPA	16	5081854	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	590305	5081854	85272899	231	46222											
RRN3	54700	broad.mit.edu	37	chr16	15180300	15180300	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattctagcagccagttgatGatctggtcatccttaagtta	11	14	8	8	0	3	2	1	2	2	0	4	2	4	2	2	1	2	3	2	1	4	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:15180300G>C	uc002dde.2	-	4	332	c.264C>G	c.(262-264)ATC>ATG	p.I88M	PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Translation_Start_Site|RRN3_uc010uzq.1_Intron|RRN3_uc002ddf.1_Missense_Mutation_p.I88M	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor	88					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1						GCCAGTTGATGATCTGGTCAT	0.303													4	73					0	0	0	0	C	15180300	C	C	15180300	3	2	252	1	0	0	0	0	1	0	0	0	13749	1280	45	2	1751	2	RRN3	16	15180300	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	10098446	15180300	75174453	232	46223											
SMG1	23049	broad.mit.edu	37	chr16	18887543	18887543	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctacattgaacacatgattcTtaaaagcctcatgttttatt	13	16	4	8	0	2	2	1	2	1	0	2	2	2	2	1	0	3	1	1	0	5	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:18887543T>A	uc002dfm.2	-	13	2156	c.1793A>T	c.(1792-1794)AAG>ATG	p.K598M	SMG1_uc010bwb.2_Missense_Mutation_p.K458M	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	598	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CACATGATTCTTAAAAGCCTC	0.373													28	62					0	0	0	0	A	18887543	A	A	18887543	3	1	252	1	0	0	0	0	1	0	0	0	14859	1609	56	5	9396	5	SMG1	16	18887543	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	3707243	18887543	71467210	233	46224											
C16orf62	57020	broad.mit.edu	37	chr16	19663399	19663399	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtggccttggccaaccaGtgcctctcccaaggtaagtc	8	8	11	14	0	1	0	0	0	1	0	3	0	1	0	5	4	2	1	5	4	3	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:19663399G>T	uc002dgn.1	+	26	2220	c.2208G>T	c.(2206-2208)CAG>CAT	p.Q736H	C16orf62_uc002dgo.1_Missense_Mutation_p.Q643H|C16orf62_uc002dgp.1_Missense_Mutation_p.Q485H	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	736						integral to membrane				ovary(1)	1						TGGCCAACCAGTGCCTCTCCC	0.542													7	6					5.18039e-06	5.31173e-06	1	0	T	19663399	T	T	19663399	3	4	252	1	0	0	0	0	1	0	0	0	1831	1020	36	4	2310	4	C16orf62	16	19663399	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	775856	19663399	70691354	234	46225											
USP31	57478	broad.mit.edu	37	chr16	23116857	23116857	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaccaatcctcatgcagtGagaacatttgccttgataca	13	10	6	12	0	1	2	1	2	0	1	2	3	2	2	3	0	4	1	3	0	3	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:23116857G>C	uc002dll.2	-	5	994	c.994C>G	c.(994-996)CAC>GAC	p.H332D		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	332					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		CTCATGCAGTGAGAACATTTG	0.438													10	33					0	0	0	0	C	23116857	C	C	23116857	3	2	252	1	0	0	0	0	1	0	0	0	17130	1290	45	2	3112	2	USP31	16	23116857	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3453458	23116857	67237896	235	46226											
COG7	91949	broad.mit.edu	37	chr16	23436072	23436072	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcaggaaggaatgtttacgtAggtgggggagcagtgccatc	10	8	17	6	1	0	0	0	0	0	0	1	3	0	3	1	5	3	4	1	5	4	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:23436072A>T	uc002dlo.2	-	7	1195	c.1007T>A	c.(1006-1008)CTA>CAA	p.L336Q		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	336					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		ATGTTTACGTAGGTGGGGGAG	0.557													31	59					0	0	0	0	T	23436072	T	T	23436072	3	4	252	1	0	0	0	0	1	0	0	0	3678	420	15	5	1349	5	COG7	16	23436072	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	319215	23436072	66918681	236	46227											
CORO1A	11151	broad.mit.edu	37	chr16	30199516	30199516	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttccccttcccacaggttCtacaagctgcacgagcggag	8	8	9	16	2	1	0	0	0	1	0	3	2	3	1	4	2	4	3	4	2	2	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:30199516C>G	uc002dww.2	+	9	1133	c.1011C>G	c.(1009-1011)TTC>TTG	p.F337L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Missense_Mutation_p.F337L|CORO1A_uc010bzr.2_Missense_Mutation_p.F337L|CORO1A_uc002dwx.2_Missense_Mutation_p.F231L|CORO1A_uc002dwy.1_3'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	337	WD 7.				cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						CCCACAGGTTCTACAAGCTGC	0.662													3	39					0	0	0	0	G	30199516	G	G	30199516	3	3	252	1	0	0	0	0	1	0	0	0	3768	912	32	2	1041	2	CORO1A	16	30199516	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	6763444	30199516	60155237	237	46228											
ZNF423	23090	broad.mit.edu	37	chr16	49559375	49559375	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggagtcgaacatctggttgCacagcttacactcgtggttg	8	11	13	9	2	1	0	0	0	1	0	3	2	1	1	0	3	4	4	0	3	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:49559375C>T	uc002efs.2	-	7	3906	c.3608G>A	c.(3607-3609)TGC>TAC	p.C1203Y	ZNF423_uc010vgn.1_Missense_Mutation_p.C1086Y	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1203	C2H2-type 28.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CATCTGGTTGCACAGCTTACA	0.572													4	22					0	0	0	0	T	49559375	T	T	49559375	3	4	252	1	0	0	0	0	1	0	0	0	17965	710	25	4	258	4	ZNF423	16	49559375	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	19359859	49559375	40795378	238	46229											
NUP93	9688	broad.mit.edu	37	chr16	56875739	56875739	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgagtcatcgaggaccgCgactctgtaagatcccagca	11	6	11	13	4	2	1	1	0	1	1	4	5	3	2	2	1	2	2	2	1	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:56875739C>T	uc002eka.2	+	21	2464	c.2343C>T	c.(2341-2343)CGC>CGT	p.R781R	NUP93_uc002ekb.2_Silent_p.R658R|NUP93_uc010vhi.1_Silent_p.R658R	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	781					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						TCGAGGACCGCGACTCTGTAA	0.512													21	10					0	0	0	0	T	56875739	T	T	56875739	2	4	252	1	0	0	0	0	0	0	0	1	10826	755	27	1		1	NUP93	16	56875739	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	7316364	56875739	33479014	239	46230											
CDH11	1009	broad.mit.edu	37	chr16	65032599	65032599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattggtgtccctgtccaccGcctgagccatcaacgtgtac	7	10	10	14	2	1	1	1	1	0	0	3	2	3	1	5	1	3	1	5	1	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr16:65032599G>A	uc002eoi.2	-	4	823	c.389C>T	c.(388-390)GCG>GTG	p.A130V	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Missense_Mutation_p.A130V|CDH11_uc010vin.1_Missense_Mutation_p.A4V|CDH11_uc010vio.1_Missense_Mutation_p.A130V	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	130	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCTGTCCACCGCCTGAGCCAT	0.527			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			17	7					0	0	0	0	A	65032599	A	A	65032599	3	1	252	1	0	0	0	0	1	0	0	0	3112	1087	38	1	2041	1	CDH11	16	65032599	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	8156860	65032599	25322154	240	46231											
MYO1C	4641	broad.mit.edu	37	chr17	1373933	1373933	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctgatctcttcacccggaGgaatttctgccgccagtgaa	9	10	9	13	2	3	2	1	2	2	0	4	4	3	4	4	2	1	0	4	2	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:1373933G>T	uc002fsp.2	-	22	2483	c.2263C>A	c.(2263-2265)CTC>ATC	p.L755I	MYO1C_uc002fsn.2_Missense_Mutation_p.L736I|MYO1C_uc002fso.2_Missense_Mutation_p.L720I|MYO1C_uc010vqj.1_Missense_Mutation_p.L720I|MYO1C_uc010vqk.1_Missense_Mutation_p.L731I	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	755	IQ 1.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TTCACCCGGAGGAATTTCTGC	0.622													10	21					0.000219431	0.000223109	1	0	T	1373933	T	T	1373933	3	4	252	1	0	0	0	0	1	0	0	0	10123	1000	35	4	972	4	MYO1C	17	1373933	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08		1373933	79821277	241	46232											
ZZEF1	23140	broad.mit.edu	37	chr17	3928237	3928237	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgttttatacaatcctttCagggccagggacaggaccca	11	10	10	10	0	1	0	1	0	0	0	2	2	2	2	3	3	1	1	3	3	3	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:3928237C>T	uc002fxe.2	-	43	7132	c.7068G>A	c.(7066-7068)CTG>CTA	p.L2356L	ZZEF1_uc002fxh.2_Silent_p.L670L|ZZEF1_uc002fxi.2_Silent_p.L591L	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2356							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACAATCCTTTCAGGGCCAGGG	0.493													8	108					0	0	0	0	T	3928237	T	T	3928237	2	4	252	1	0	0	0	0	0	0	0	1	18322	813	29	2		2	ZZEF1	17	3928237	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	2554304	3928237	77266973	242	46233											
POLR2A	5430	broad.mit.edu	37	chr17	7404130	7404130	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatcccgatgatgaagacaGtggcccttacaagcacatct	12	8	8	13	1	1	3	0	2	1	1	2	4	2	3	3	1	2	1	3	1	3	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:7404130G>A	uc002ghf.3	+	11	2078	c.1844G>A	c.(1843-1845)AGT>AAT	p.S615N		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	615					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				GATGAAGACAGTGGCCCTTAC	0.547													98	7					0	0	0	0	A	7404130	A	A	7404130	3	1	252	1	0	0	0	0	1	0	0	0	12269	1029	36	4	1886	4	POLR2A	17	7404130	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3475893	7404130	73791080	243	46234											
TP53	7157	broad.mit.edu	37	chr17	7577085	7577085	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttgcggagattctcttcctCtgtgcgccggtctctcccag	3	13	10	15	3	3	1	0	0	3	1	7	2	5	1	3	2	2	0	3	2	0	3	rs112431538		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:7577085C>T	uc002gim.2	-	8	1047	c.853G>A	c.(853-855)GAG>AAG	p.E285K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E285K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E153K|TP53_uc010cng.1_Missense_Mutation_p.E153K|TP53_uc002gii.1_Missense_Mutation_p.E153K|TP53_uc010cnh.1_Missense_Mutation_p.E285K|TP53_uc010cni.1_Missense_Mutation_p.E285K|TP53_uc002gij.2_Missense_Mutation_p.E285K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	285	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(95)|p.E285*(16)|p.E285V(13)|p.0?(7)|p.E285Q(4)|p.E285E(3)|p.E285G(3)|p.E285A(2)|p.?(2)|p.R283fs*16(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.C275fs*20(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	9					0	0	0	0	T	7577085	T	T	7577085	3	4	252	1	0	0	0	0	1	0	0	0	16448	922	32	2	433	2	TP53	17	7577085	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	172955	7577085	73618125	244	46235											
DNAH2	146754	broad.mit.edu	37	chr17	7735024	7735024	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcatccagggtctcatcgtCatgtctacaagcctggaaga	10	9	11	11	1	3	1	2	0	2	1	6	2	4	2	2	3	2	1	2	3	3	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:7735024C>G	uc002giu.1	+	81	12671	c.12657C>G	c.(12655-12657)GTC>GTG	p.V4219V	DNAH2_uc010cnm.1_Silent_p.V1157V	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4219					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GTCTCATCGTCATGTCTACAA	0.488													11	48					0	0	0	0	G	7735024	G	G	7735024	2	3	252	1	0	0	0	0	0	0	0	1	4624	813	29	2		2	DNAH2	17	7735024	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	157939	7735024	73460186	245	46236											
NCOR1	9611	broad.mit.edu	37	chr17	16024584	16024584	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttttccttggtattttctCtggacacaaaagcaaatgaa	12	14	6	9	0	1	1	0	1	1	0	3	2	2	2	2	2	1	2	2	2	5	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:16024584C>T	uc002gpo.2	-	16	1875	c.1635_splice	c.e16-1	p.K545_splice	NCOR1_uc002gpn.2_Splice_Site_p.K545_splice|NCOR1_uc002gpp.1_Splice_Site_p.K436_splice|NCOR1_uc002gpr.2_Splice_Site_p.K436_splice	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1						cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GGTATTTTCTCTGGACACAAA	0.383													5	132					0	0	0	0	T	16024584	T	T	16024584	5	4	252	1	0	0	0	0	0	0	1	0	10289	927	32	2	5812	2	NCOR1	17	16024584	Splice_Site	SNP	C	TCGA-CV-7414-01A-11D-2078-08	8289560	16024584	65170626	246	46237											
MYO15A	51168	broad.mit.edu	37	chr17	18023707	18023707	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgccctacggccaccctttCtggggcttcctcacgccgcg	3	9	11	18	4	2	0	1	0	1	0	3	0	3	0	5	3	2	1	5	3	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:18023707C>G	uc010vxh.1	+	2	1931	c.1593C>G	c.(1591-1593)TTC>TTG	p.F531L		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	531	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GCCACCCTTTCTGGGGCTTCC	0.706													4	9					0	0	0	0	G	18023707	G	G	18023707	3	3	252	1	0	0	0	0	1	0	0	0	10116	912	32	2	1595	2	MYO15A	17	18023707	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1999123	18023707	63171503	247	46238											
SHMT1	6470	broad.mit.edu	37	chr17	18238931	18238931	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggaacacagcagaattgatAagagactccaggttgtacag	15	7	12	7	0	0	3	0	1	0	2	1	5	1	4	1	2	3	3	1	2	4	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:18238931A>C	uc002gta.2	-	8	1063	c.873T>G	c.(871-873)CTT>CTG	p.L291L	SHMT1_uc002gsz.2_Silent_p.L66L|SHMT1_uc002gtb.2_Intron|SHMT1_uc010cqb.2_Silent_p.L291L|SHMT1_uc010vxt.1_Silent_p.L153L|SHMT1_uc002gtc.1_5'Flank|SHMT1_uc002gtd.1_Silent_p.L291L	NM_004169	NP_004160	P34896	GLYC_HUMAN	serine hydroxymethyltransferase 1 (soluble)	291					carnitine biosynthetic process|folic acid metabolic process|L-serine catabolic process|one-carbon metabolic process|purine base biosynthetic process	cytosol|nucleus	glycine hydroxymethyltransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					Glycine(DB00145)|Mimosine(DB01055)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CAGAATTGATAAGAGACTCCA	0.502													102	92					0	0	0	0	C	18238931	C	C	18238931	2	2	252	1	0	0	0	0	0	0	0	1	14350	349	13	5		5	SHMT1	17	18238931	Silent	SNP	A	TCGA-CV-7414-01A-11D-2078-08	215224	18238931	62956279	248	46239											
TRIM16L	147166	broad.mit.edu	37	chr17	18638380	18638380	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtactattttgaggtggaGatcttcggggcaggcaccta	9	11	14	7	1	1	2	0	1	1	1	2	3	1	2	1	6	1	3	1	6	3	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:18638380G>T	uc002gug.1	+	10	1341	c.654G>T	c.(652-654)GAG>GAT	p.E218D	TRIM16L_uc010vyf.1_Missense_Mutation_p.E272D|TRIM16L_uc002guh.1_Missense_Mutation_p.E218D|TRIM16L_uc010cqg.1_Missense_Mutation_p.E320D|TRIM16L_uc002gui.1_Missense_Mutation_p.E218D|TRIM16L_uc010vyg.1_Missense_Mutation_p.E218D|TRIM16L_uc010vyh.1_Missense_Mutation_p.R131I	NM_001037330	NP_001032407	Q309B1	TR16L_HUMAN	tripartite motif-containing 16-like	218	B30.2/SPRY.					cytoplasm					0						TTGAGGTGGAGATCTTCGGGG	0.587													42	2					1.41504e-22	1.4973e-22	1	0	T	18638380	T	T	18638380	3	4	252	1	0	0	0	0	1	0	0	0	16559	933	33	2	668	2	TRIM16L	17	18638380	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	399449	18638380	62556830	249	46240											
ATAD5	79915	broad.mit.edu	37	chr17	29220591	29220591	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaaacattggtaatattaGatgatagtgatctatttgac	16	14	8	3	0	1	5	0	3	1	2	1	5	1	5	0	1	1	1	0	1	7	7			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:29220591G>C	uc002hfs.1	+	21	5066	c.4720G>C	c.(4720-4722)GAT>CAT	p.D1574H		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1574					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GGTAATATTAGATGATAGTGA	0.358													11	46					0	0	0	0	C	29220591	C	C	29220591	3	2	252	1	0	0	0	0	1	0	0	0	1078	942	33	2	4802	2	ATAD5	17	29220591	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	10582211	29220591	51974619	250	46241											
ATAD5	79915	broad.mit.edu	37	chr17	29221718	29221718	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaagactgagaagctaaaaGaacaaggaaaaagtaaaaga	24	4	10	3	0	0	4	0	1	0	4	0	6	0	5	0	1	2	3	0	1	10	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:29221718G>C	uc002hfs.1	+	22	5780	c.5434G>C	c.(5434-5436)GAA>CAA	p.E1812Q		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1812					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GAAGCTAAAAGAACAAGGAAA	0.303													7	36					0	0	0	0	C	29221718	C	C	29221718	3	2	252	1	0	0	0	0	1	0	0	0	1078	943	33	2	5520	2	ATAD5	17	29221718	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1127	29221718	51973492	251	46242											
FBXL20	84961	broad.mit.edu	37	chr17	37421664	37421664	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actcaccaatacttgaagtcGaggacagtgtatagaaagtt	15	10	9	7	1	1	2	1	1	0	1	2	4	1	3	1	1	1	2	1	1	6	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:37421664G>A	uc010wed.1	-	13	1197	c.976C>T	c.(976-978)CGA>TGA	p.R326*	FBXL20_uc002hrt.2_Nonsense_Mutation_p.R326*|FBXL20_uc010cvu.2_Nonsense_Mutation_p.R294*	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	326	LRR 10.					cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			ACTTGAAGTCGAGGACAGTGT	0.338													16	101					0	0	0	0	A	37421664	A	A	37421664	4	1	252	1	0	0	0	0	0	1	0	0	5749	1066	37	1	346	1	FBXL20	17	37421664	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	8199946	37421664	43773546	252	46243											
MED1	5469	broad.mit.edu	37	chr17	37565028	37565028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagcctggcttccccccaGactgggatgaatttttggac	8	10	12	11	0	0	2	0	1	0	1	1	5	1	5	4	4	1	1	4	4	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:37565028G>A	uc002hrv.3	-	17	3658	c.3446C>T	c.(3445-3447)TCT>TTT	p.S1149F	MED1_uc010wee.1_Missense_Mutation_p.S977F|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1149	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		CTTCCCCCCAGACTGGGATGA	0.478										HNSCC(31;0.082)			9	74					0	0	0	0	A	37565028	A	A	37565028	3	1	252	1	0	0	0	0	1	0	0	0	9478	942	33	2	1303	2	MED1	17	37565028	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	143364	37565028	43630182	253	46244											
MED1	5469	broad.mit.edu	37	chr17	37565889	37565889	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatcaggattgaaatctactCcatcatgaaaaaaatgattg	18	11	6	6	0	3	3	2	3	1	0	4	4	4	4	1	1	1	0	1	1	6	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:37565889C>T	uc002hrv.3	-	17	2797	c.2585G>A	c.(2584-2586)GGA>GAA	p.G862E	MED1_uc010wee.1_Missense_Mutation_p.G690E|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	862	Interaction with ESR1.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GAAATCTACTCCATCATGAAA	0.388										HNSCC(31;0.082)			31	223					0	0	0	0	T	37565889	T	T	37565889	3	4	252	1	0	0	0	0	1	0	0	0	9478	855	30	2	2164	2	MED1	17	37565889	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	861	37565889	43629321	254	46245											
KRT26	353288	broad.mit.edu	37	chr17	38928008	38928008	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agagccaggctcacatttctCgtaccagcccttgatcttct	8	12	7	14	1	4	2	1	1	3	1	5	2	4	2	3	1	3	2	3	1	1	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:38928008C>G	uc002hvf.2	-	1	404	c.358G>C	c.(358-360)GAG>CAG	p.E120Q		NM_181539	NP_853517	Q7Z3Y9	K1C26_HUMAN	keratin 26	120	Rod.|Linker 1.					intermediate filament	structural molecule activity				0		Breast(137;0.00526)				TCACATTTCTCGTACCAGCCC	0.498													10	104					0	0	0	0	G	38928008	G	G	38928008	3	3	252	1	0	0	0	0	1	0	0	0	8502	893	31	3	1080	3	KRT26	17	38928008	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	1362119	38928008	42267202	255	46246											
WNK4	65266	broad.mit.edu	37	chr17	40932738	40932738	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgttggcatccccggccacgGagaccaccgtcctcatgtcc	6	8	10	17	3	1	1	1	0	0	1	4	2	4	1	7	3	0	2	7	3	0	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:40932738G>C	uc002ibj.2	+	1	43	c.22G>C	c.(22-24)GAG>CAG	p.E8Q	WNK4_uc010wgx.1_5'UTR|WNK4_uc002ibk.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	8					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCCGGCCACGGAGACCACCGT	0.711													9	6					0	0	0	0	C	40932738	C	C	40932738	3	2	252	1	0	0	0	0	1	0	0	0	17448	1175	41	2	24	2	WNK4	17	40932738	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	2004730	40932738	40262472	256	46247											
CACNA1G	8913	broad.mit.edu	37	chr17	48678415	48678416	+	Missense_Mutation	DNP	CC	TT	TT																															cctccatgcctgggcaggttCcgcctcctgtgtcaccggat																										TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:48678415_48678416CC>TT	uc002irk.1	+	19	4167_4168	c.3795_3796CC>TT	c.(3793-3798)TTCCGC>TTTTGC	p.R1266C	CACNA1G_uc002iri.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irj.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irl.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irm.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irn.1_Missense_Mutation_p.R1243C|CACNA1G_uc002iro.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irp.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irq.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irr.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irs.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irt.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irv.1_Missense_Mutation_p.R1266C|CACNA1G_uc002irw.1_Missense_Mutation_p.R1243C|CACNA1G_uc002iru.1_Missense_Mutation_p.R1243C|CACNA1G_uc002irx.1_Missense_Mutation_p.R1179C|CACNA1G_uc002iry.1_Missense_Mutation_p.R1179C|CACNA1G_uc002irz.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isa.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isb.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isc.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isd.1_Missense_Mutation_p.R1179C|CACNA1G_uc002ise.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isf.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isg.1_Missense_Mutation_p.R1179C|CACNA1G_uc002ish.1_Missense_Mutation_p.R1179C|CACNA1G_uc002isi.1_Missense_Mutation_p.R1156C|CACNA1G_uc002isj.2_5'UTR	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1266	Cytoplasmic (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TGGGCAGGTTCCGCCTCCTGTG	0.639													3	47					0	0	0	0	TT	48678416	TT	TT	48678415	3	4	252	1	0	0	0	0	1	0	0	0	2556	854	30	2	3869	2	CACNA1G	17	48678415	Missense_Mutation	DNP	CC	TCGA-CV-7414-01A-11D-2078-08	7745677	48678415	32516795	257	46248											
SPAG9	9043	broad.mit.edu	37	chr17	49057213	49057213	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcgaatggagacccacacGccatcccccacccacgcaag	13	2	8	18	3	0	1	0	0	0	1	1	3	1	1	5	1	1	1	5	1	3	0	rs149696370		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:49057213G>C	uc002itc.2	-	26	3512	c.3303C>G	c.(3301-3303)GGC>GGG	p.G1101G	SPAG9_uc002itb.2_Silent_p.G1087G|SPAG9_uc002itd.2_Silent_p.G1091G|SPAG9_uc002ita.2_Silent_p.G944G	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	1101					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			AGACCCACACGCCATCCCCCA	0.473													26	14					0	0	0	0	C	49057213	C	C	49057213	2	2	252	1	0	0	0	0	0	0	0	1	15051	1074	38	3		3	SPAG9	17	49057213	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	378798	49057213	32137997	258	46249											
CSH2	1443	broad.mit.edu	37	chr17	61949939	61949939	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccctggcgccaccctcacccCcatcagcgtttggatgcctt	5	9	8	19	2	2	0	2	0	0	0	2	1	2	1	6	2	2	1	6	2	0	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:61949939C>A	uc002jch.2	-	4	569	c.454G>T	c.(454-456)GGG>TGG	p.G152W	CSH2_uc002jcg.2_Intron|CSH2_uc002jci.2_Missense_Mutation_p.G152W|GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Missense_Mutation_p.G152W	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	152					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						ACCCTCACCCCCATCAGCGTT	0.582													14	84					8.60227e-14	8.99778e-14	1	0	A	61949939	A	A	61949939	3	1	252	1	0	0	0	0	1	0	0	0	3958	623	22	4	255	4	CSH2	17	61949939	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	12892726	61949939	19245271	259	46250											
PRKCA	5578	broad.mit.edu	37	chr17	64299066	64299066	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgaggcagaagaacgtgcacGaggtgaaggaccacaaattc	15	5	13	8	2	0	4	0	2	0	2	1	6	0	5	1	3	2	2	1	3	4	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:64299066G>C	uc002jfp.1	+	1	141	c.97G>C	c.(97-99)GAG>CAG	p.E33Q	PRKCA_uc002jfo.1_5'UTR	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	33					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	GAACGTGCACGAGGTGAAGGA	0.627													21	40					0	0	0	0	C	64299066	C	C	64299066	3	2	252	1	0	0	0	0	1	0	0	0	12569	1059	37	3	99	3	PRKCA	17	64299066	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	2349127	64299066	16896144	260	46251											
HELZ	9931	broad.mit.edu	37	chr17	65119122	65119122	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataactacattccctccataGacagcaggtacataaagaat	17	9	5	10	0	0	2	0	0	0	2	2	2	2	2	2	1	4	2	2	1	7	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:65119122G>C	uc010wqk.1	-	26	3784	c.3597C>G	c.(3595-3597)GTC>GTG	p.V1199V	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.V1198V	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TCCCTCCATAGACAGCAGGTA	0.408													9	86					0	0	0	0	C	65119122	C	C	65119122	2	2	252	1	0	0	0	0	0	0	0	1	7088	929	33	2		2	HELZ	17	65119122	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	820056	65119122	16076088	261	46252											
QRICH2	84074	broad.mit.edu	37	chr17	74287156	74287156	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttggccggcctgctcctcatCcagatccttcatactctcct	5	13	6	17	1	3	1	2	0	1	1	7	1	6	1	6	2	2	1	6	2	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:74287156C>G	uc002jrd.1	-	4	3334	c.3154G>C	c.(3154-3156)GAT>CAT	p.D1052H	QRICH2_uc010wsz.1_Missense_Mutation_p.D978H|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1052							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						TGCTCCTCATCCAGATCCTTC	0.527													32	63					0	0	0	0	G	74287156	G	G	74287156	3	3	252	1	0	0	0	0	1	0	0	0	12945	855	30	2	1901	2	QRICH2	17	74287156	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	9168034	74287156	6908054	262	46253											
ENPP7	339221	broad.mit.edu	37	chr17	77710865	77710865	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	taacgtccagttcaacaatgGggagcacggctttgacaaca	13	8	10	10	2	1	1	1	1	0	0	2	2	2	2	1	3	4	3	1	3	4	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:77710865G>A	uc002jxa.2	+	4	1072	c.1052G>A	c.(1051-1053)GGG>GAG	p.G351E		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	351					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TTCAACAATGGGGAGCACGGC	0.602													28	6					0	0	0	0	A	77710865	A	A	77710865	3	1	252	1	0	0	0	0	1	0	0	0	5159	1232	43	4	1066	4	ENPP7	17	77710865	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3423709	77710865	3484345	263	46254											
RNF213	57674	broad.mit.edu	37	chr17	78321903	78321903	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgtctgaggaggccaaatcGatcctgctgaactgcgctac	9	9	12	11	2	1	2	0	2	1	0	3	4	2	3	2	2	4	2	2	2	3	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:78321903G>A	uc002jyh.1	+	4	4210	c.3987G>A	c.(3985-3987)TCG>TCA	p.S1329S		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AGGCCAAATCGATCCTGCTGA	0.642													37	6					0	0	0	0	A	78321903	A	A	78321903	2	1	252	1	0	0	0	0	0	0	0	1	13542	1045	37	1		1	RNF213	17	78321903	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	611038	78321903	2873307	264	46255											
ZNF750	79755	broad.mit.edu	37	chr17	80789425	80789425	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggaaaaacctgtagtgatcGtatgtggctggagatggagc	11	10	15	5	1	0	2	0	1	0	1	1	5	0	4	1	4	2	3	1	4	4	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr17:80789425G>C	uc002kga.2	-	2	1217	c.906C>G	c.(904-906)TAC>TAG	p.Y302*	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	302						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGTAGTGATCGTATGTGGCTG	0.547													115	31					0	0	0	0	C	80789425	C	C	80789425	4	2	252	1	0	0	0	0	0	1	0	0	18199	1140	40	3	1273	3	ZNF750	17	80789425	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	2467522	80789425	405785	265	46256											
COLEC12	81035	broad.mit.edu	37	chr18	346848	346848	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagctctgcactttctccttCagccaatccgtgtccttctt	6	15	5	15	1	4	0	1	0	3	0	7	0	6	0	4	0	3	2	4	0	2	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:346848C>T	uc002kkm.2	-	5	989	c.774G>A	c.(772-774)CTG>CTA	p.L258L		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	258	Potential.|Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CTTTCTCCTTCAGCCAATCCG	0.512													9	30					0	0	0	0	T	346848	T	T	346848	2	4	252	1	0	0	0	0	0	0	0	1	3727	813	29	2		2	COLEC12	18	346848	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08		346848	77730400	266	46257											
CTAGE1	64693	broad.mit.edu	37	chr18	19995601	19995601	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtaaggaagaaaacctctcGgtaaatagacatttctcatt	15	11	8	7	1	2	2	1	0	2	2	4	3	2	3	1	3	1	2	1	3	7	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:19995601G>T	uc002ktv.1	-	1	2278	c.2174C>A	c.(2173-2175)CCG>CAG	p.P725Q		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	725	Pro-rich.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AAAACCTCTCGGTAAATAGAC	0.498													22	26					5.26018e-13	5.47059e-13	1	0	T	19995601	T	T	19995601	3	4	252	1	0	0	0	0	1	0	0	0	4009	1116	39	3	67	3	CTAGE1	18	19995601	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	19648753	19995601	58081647	267	46258											
KIAA1012	22878	broad.mit.edu	37	chr18	29437875	29437875	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taagtggacatttgctgacaTtgacaaattctacatatgct	13	14	7	7	0	1	2	0	2	1	0	1	3	1	3	0	1	3	2	0	1	4	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:29437875T>C	uc002kxc.3	-	20	3180	c.2816A>G	c.(2815-2817)AAT>AGT	p.N939S	KIAA1012_uc002kxb.3_Missense_Mutation_p.N885S|KIAA1012_uc002kxd.3_Intron	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	939					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TTTGCTGACATTGACAAATTC	0.378													58	98					0	0	0	0	C	29437875	C	C	29437875	3	2	252	1	0	0	0	0	1	0	0	0	8243	1493	52	5	1531	5	KIAA1012	18	29437875	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	9442274	29437875	48639373	268	46259											
SETBP1	26040	broad.mit.edu	37	chr18	42532870	42532870	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagccacatcctgagcgagCggctgagtagcgcagacaaa	12	4	12	13	3	0	3	0	2	0	1	1	4	1	3	3	1	4	3	3	1	2	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:42532870C>T	uc010dni.2	+	4	3861	c.3565C>T	c.(3565-3567)CGG>TGG	p.R1189W		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1189						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCTGAGCGAGCGGCTGAGTAG	0.552									Schinzel-Giedion_syndrome				3	43					0	0	0	0	T	42532870	T	T	42532870	3	4	252	1	0	0	0	0	1	0	0	0	14194	759	27	1	3768	1	SETBP1	18	42532870	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	13094995	42532870	35544378	269	46260											
CDH7	1005	broad.mit.edu	37	chr18	63489364	63489364	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatagagaggctaaagacCagtatttgcttgtcattcag	12	12	11	6	0	2	2	2	0	0	2	2	4	2	3	1	2	1	3	1	2	4	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:63489364C>A	uc002ljz.2	+	5	998	c.673C>A	c.(673-675)CAG>AAG	p.Q225K	CDH7_uc002lka.2_Missense_Mutation_p.Q225K|CDH7_uc002lkb.2_Missense_Mutation_p.Q225K	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	225	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GGCTAAAGACCAGTATTTGCT	0.403													18	34					5.35267e-07	5.51946e-07	1	0	A	63489364	A	A	63489364	3	1	252	1	0	0	0	0	1	0	0	0	3130	595	21	4	687	4	CDH7	18	63489364	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	20956494	63489364	14587884	270	46261											
CTDP1	9150	broad.mit.edu	37	chr18	77513778	77513778	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcgctggaggcggagctcaaCgacctcatgtgagcgcgggc	7	5	17	12	5	2	1	2	1	0	0	2	4	2	3	1	4	3	2	1	4	1	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr18:77513778C>T	uc002lnh.1	+	13	3021	c.2874C>T	c.(2872-2874)AAC>AAT	p.N958N	CTDP1_uc002lni.1_3'UTR|CTDP1_uc010drd.1_3'UTR	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	958					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CGGAGCTCAACGACCTCATGT	0.687													9	13					0	0	0	0	T	77513778	T	T	77513778	2	4	252	1	0	0	0	0	0	0	0	1	4019	535	19	1		1	CTDP1	18	77513778	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	14024414	77513778	563470	271	46262											
APC2	10297	broad.mit.edu	37	chr19	1462153	1462153	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccgcaatgtgtccagcctCgtcgccacccgtgaggacta	7	8	10	16	4	0	1	0	1	0	0	4	2	2	2	5	1	1	1	5	1	2	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:1462153C>T	uc002lsr.1	+	14	2038	c.1830C>T	c.(1828-1830)CTC>CTT	p.L610L	APC2_uc002lss.1_Silent_p.L192L|APC2_uc002lst.1_Silent_p.L610L|APC2_uc002lsu.1_Silent_p.L609L|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	610					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTCCAGCCTCGTCGCCACCC	0.692													4	5					0	0	0	0	T	1462153	T	T	1462153	2	4	252	1	0	0	0	0	0	0	0	1	764	871	31	1		1	APC2	19	1462153	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08		1462153	57666830	272	46263											
ADAMTSL5	339366	broad.mit.edu	37	chr19	1510410	1510410	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgggagtctccccagcacGgttcttccccaggaagcctg	7	8	11	15	1	2	0	0	0	2	0	4	2	3	2	5	3	2	2	5	3	1	2	rs149832091		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:1510410G>C	uc002ltd.2	-	4	653	c.209C>G	c.(208-210)CCG>CGG	p.P70R	ADAMTSL5_uc010dsl.2_5'UTR|ADAMTSL5_uc010xgq.1_Missense_Mutation_p.P80R	NM_213604	NP_998769	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5 precursor	70	TSP type-1.					proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCCAGCACGGTTCTTCCCC	0.672													4	12					0	0	0	0	C	1510410	C	C	1510410	3	2	252	1	0	0	0	0	1	0	0	0	278	1116	39	3	1242	3	ADAMTSL5	19	1510410	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	48257	1510410	57618573	273	46264											
S1PR4	8698	broad.mit.edu	37	chr19	3179237	3179237	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgctttgccaccatggtgcgGccggtggccgagagcggggc	4	6	18	13	5	0	1	0	0	0	1	0	2	0	1	4	6	3	1	4	6	0	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:3179237G>A	uc002lxg.2	+	1	472	c.447G>A	c.(445-447)CGG>CGA	p.R149R		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	149	Cytoplasmic (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						CCATGGTGCGGCCGGTGGCCG	0.692													4	66					0	0	0	0	A	3179237	A	A	3179237	2	1	252	1	0	0	0	0	0	0	0	1	13861	1190	42	4		4	S1PR4	19	3179237	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1668827	3179237	55949746	274	46265											
PLIN3	10226	broad.mit.edu	37	chr19	4859609	4859609	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggacatcgttaccttctccGtgggctgctgcaggatgggg	5	10	15	11	3	1	0	0	0	1	0	3	2	1	2	2	5	3	4	2	5	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:4859609G>A	uc002mbj.2	-	4	518	c.341C>T	c.(340-342)ACG>ATG	p.T114M	PLIN3_uc002mbk.2_Missense_Mutation_p.T114M|PLIN3_uc002mbl.3_Missense_Mutation_p.T114M	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	114					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	TACCTTCTCCGTGGGCTGCTG	0.572													21	29					0	0	0	0	A	4859609	A	A	4859609	3	1	252	1	0	0	0	0	1	0	0	0	12146	1145	40	1	983	1	PLIN3	19	4859609	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1680372	4859609	54269374	275	46266											
MUC16	94025	broad.mit.edu	37	chr19	9085082	9085082	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagacagtgggaatactctCagccccatctgaaggtgtgt	10	9	13	9	0	2	2	1	1	2	1	3	4	2	3	2	3	2	0	2	3	3	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:9085082C>T	uc002mkp.2	-	1	6937	c.6733G>A	c.(6733-6735)GAG>AAG	p.E2245K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2245	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAATACTCTCAGCCCCATCT	0.448													11	19					0	0	0	0	T	9085082	T	T	9085082	3	4	252	1	0	0	0	0	1	0	0	0	10026	835	29	2	37126	2	MUC16	19	9085082	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	4225473	9085082	50043901	276	46267											
ZNF699	374879	broad.mit.edu	37	chr19	9407596	9407596	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataacattcatagatgttctCtaccatatgatttcttttaa	13	18	3	7	0	3	2	1	1	2	1	4	2	3	2	1	0	2	1	1	0	5	9			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:9407596C>G	uc002mlc.1	-	5	484	c.484G>C	c.(484-486)GAG>CAG	p.E162Q		NM_198535	NP_940937	Q32M78	ZN699_HUMAN	zinc finger protein 699	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGATGTTCTCTACCATATGA	0.299													5	18					0	0	0	0	G	9407596	G	G	9407596	3	3	252	1	0	0	0	0	1	0	0	0	18168	922	32	2	1448	2	ZNF699	19	9407596	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	322514	9407596	49721387	277	46268											
MAN2B1	4125	broad.mit.edu	37	chr19	12776599	12776599	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtgcacgttcagcatgttCggctgcactgtggggcatgt	6	11	15	9	2	1	0	1	0	0	0	2	0	1	0	0	4	3	7	0	4	0	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:12776599C>T	uc002mub.2	-	2	256	c.180G>A	c.(178-180)CCG>CCA	p.P60P	MAN2B1_uc010dyv.1_Silent_p.P60P|WDR83_uc002mue.3_5'Flank|WDR83_uc002muc.2_5'Flank	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	60					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						TCAGCATGTTCGGCTGCACTG	0.547													15	33					0	0	0	0	T	12776599	T	T	12776599	2	4	252	1	0	0	0	0	0	0	0	1	9269	871	31	1		1	MAN2B1	19	12776599	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3369003	12776599	46352384	278	46269											
DHPS	1725	broad.mit.edu	37	chr19	12790281	12790281	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcctcaccttctgggccCagtaatacacggactctggg	8	9	11	13	1	3	0	1	0	2	0	4	1	4	1	3	4	1	1	3	4	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:12790281C>T	uc002muh.1	-	5	765	c.668G>A	c.(667-669)TGG>TAG	p.W223*	DHPS_uc002muf.1_Nonsense_Mutation_p.W100*|DHPS_uc002mug.1_Nonsense_Mutation_p.W181*|DHPS_uc002mui.1_Nonsense_Mutation_p.W223*|DHPS_uc002muj.1_Nonsense_Mutation_p.W223*|DHPS_uc002muk.1_RNA|DHPS_uc010xmn.1_RNA	NM_001930	NP_001921	P49366	DHYS_HUMAN	deoxyhypusine synthase isoform a	223					peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)	1					Sulfadoxine(DB01299)	CTTCTGGGCCCAGTAATACAC	0.398													72	98					0	0	0	0	T	12790281	T	T	12790281	4	4	252	1	0	0	0	0	0	1	0	0	4507	595	21	4	461	4	DHPS	19	12790281	Nonsense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	13682	12790281	46338702	279	46270											
CC2D1A	54862	broad.mit.edu	37	chr19	14038078	14038078	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggtccgggagatccttgaGgtgagaggtggacattcatc	9	9	16	7	1	1	3	1	2	0	2	4	7	3	4	2	5	0	0	2	5	0	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:14038078G>T	uc002mxo.2	+	22	2615	c.2316G>T	c.(2314-2316)GAG>GAT	p.E772D	CC2D1A_uc002mxp.2_Missense_Mutation_p.E772D|CC2D1A_uc010dzh.2_Missense_Mutation_p.E341D|CC2D1A_uc002mxq.1_3'UTR	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	772					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			AGATCCTTGAGGTGAGAGGTG	0.547													3	48					6.4e-05	6.54382e-05	1	0	T	14038078	T	T	14038078	3	4	252	1	0	0	0	0	1	0	0	0	2738	1014	35	4	2402	4	CC2D1A	19	14038078	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1247797	14038078	45090905	280	46271											
PKN1	5585	broad.mit.edu	37	chr19	14562741	14562741	+	Frame_Shift_Del	DEL	C	-	-																															cctgggaccccagacagccgCccccccttcctgagccgccc																										TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:14562741delC	uc002myp.2	+	7	1239	c.1071delC	c.(1069-1071)CGCfs	p.R357fs	PKN1_uc002myq.2_Frame_Shift_Del_p.R363fs	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	357	C2.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8						CAGACAGCCGCCCCCCCTTCC	0.667													---	---	---								-	14562741	-	-	14562741	7	5	252	1	0	1	0	1	0	0	0	0	12034	726	26	0	1140	0	PKN1	19	14562741	Frame_Shift_Del	DEL	C	TCGA-CV-7414-01A-11D-2078-08	524663	14562741	44566242	281	46272											
TSSK6	83983	broad.mit.edu	37	chr19	19626011	19626011	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcacacctcgatgaactcgaAgacgtgcacgatgtgcgggt	10	7	13	11	5	0	2	0	1	0	1	2	5	0	2	1	1	3	2	1	1	2	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:19626011A>G	uc002nmr.2	-	1	459	c.226T>C	c.(226-228)TTC>CTC	p.F76L	TSSK6_uc002nmq.2_RNA|NDUFA13_uc002nms.2_5'Flank|NDUFA13_uc010xqx.1_5'Flank|NDUFA13_uc010xqy.1_5'Flank	NM_032037	NP_114426	Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6	76	Protein kinase.				multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1						ATGAACTCGAAGACGTGCACG	0.667													11	26					0	0	0	0	G	19626011	G	G	19626011	3	3	252	1	0	0	0	0	1	0	0	0	16739	72	3	5	599	5	TSSK6	19	19626011	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	5063270	19626011	39502972	282	46273											
ZNF91	7644	broad.mit.edu	37	chr19	23544721	23544721	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctaaaagctttgccacattCtttacatttgtagggtttct	9	17	7	8	0	2	0	0	0	2	0	2	0	2	0	1	1	3	4	1	1	4	8			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:23544721C>G	uc002nre.2	-	4	1173	c.1060G>C	c.(1060-1062)GAA>CAA	p.E354Q	ZNF91_uc010xrj.1_Missense_Mutation_p.E322Q	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	354	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTGCCACATTCTTTACATTTG	0.368													14	32					0	0	0	0	G	23544721	G	G	23544721	3	3	252	1	0	0	0	0	1	0	0	0	18267	922	32	2	2519	2	ZNF91	19	23544721	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	3918710	23544721	35584262	283	46274											
ZNF536	9745	broad.mit.edu	37	chr19	30935350	30935350	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagctggaccgccacatccGcatcttgcacaagccctaca	10	6	9	16	2	1	0	0	0	1	0	2	2	2	2	4	2	4	3	4	2	2	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:30935350G>A	uc002nsu.1	+	2	1019	c.881G>A	c.(880-882)CGC>CAC	p.R294H	ZNF536_uc010edd.1_Missense_Mutation_p.R294H	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	294	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CGCCACATCCGCATCTTGCAC	0.647													33	45					0	0	0	0	A	30935350	A	A	30935350	3	1	252	1	0	0	0	0	1	0	0	0	18041	1087	38	1	883	1	ZNF536	19	30935350	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	7390629	30935350	28193633	284	46275											
FCGBP	8857	broad.mit.edu	37	chr19	40363228	40363228	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagaaccatgtttcggccctCggcggtcacccgcacgcggc	6	6	12	17	6	1	1	1	0	0	1	3	1	1	1	3	4	1	2	3	4	1	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:40363228C>T	uc002omp.3	-	32	14850	c.14842G>A	c.(14842-14844)GAG>AAG	p.E4948K		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4948	VWFD 12.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TTTCGGCCCTCGGCGGTCACC	0.662													10	13					0	0	0	0	T	40363228	T	T	40363228	3	4	252	1	0	0	0	0	1	0	0	0	5810	893	31	1	1395	1	FCGBP	19	40363228	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	9427878	40363228	18765755	285	46276											
ZNF226	7769	broad.mit.edu	37	chr19	44680376	44680376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaattcagtcagggcgctCatctacagacccatcagaaa	14	7	9	11	1	5	2	4	0	1	2	5	3	5	3	1	2	1	1	1	2	3	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:44680376C>T	uc002oyp.2	+	6	1105	c.961C>T	c.(961-963)CAT>TAT	p.H321Y	ZNF226_uc002oyq.2_Missense_Mutation_p.H204Y|ZNF226_uc002oyr.2_Missense_Mutation_p.H204Y|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.H321Y|ZNF226_uc002oyt.2_Missense_Mutation_p.H321Y	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	321	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TCAGGGCGCTCATCTACAGAC	0.428													5	38					0	0	0	0	T	44680376	T	T	44680376	3	4	252	1	0	0	0	0	1	0	0	0	17847	826	29	2	1029	2	ZNF226	19	44680376	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	4317148	44680376	14448607	286	46277											
ZNF320	162967	broad.mit.edu	37	chr19	53385154	53385154	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtgataacttgcttgtctCtgcaatgtccctgtgtggat	7	16	10	8	0	1	1	0	1	1	0	3	2	2	2	1	1	3	2	1	1	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:53385154C>T	uc002qag.2	-	4	416	c.225G>A	c.(223-225)CAG>CAA	p.Q75Q	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Silent_p.Q21Q|ZNF320_uc002qai.2_Silent_p.Q75Q	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	75	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TTGCTTGTCTCTGCAATGTCC	0.393													11	149					0	0	0	0	T	53385154	T	T	53385154	2	4	252	1	0	0	0	0	0	0	0	1	17906	912	32	2		2	ZNF320	19	53385154	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	8704778	53385154	5743829	287	46278											
ZNF347	84671	broad.mit.edu	37	chr19	53652521	53652521	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggccaggttcctataattctCcaacatcacgtccctgtaca	10	11	6	14	1	2	0	1	0	1	0	5	0	4	0	4	2	2	2	4	2	4	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:53652521C>G	uc002qbb.1	-	3	184	c.115G>C	c.(115-117)GAG>CAG	p.E39Q	ZNF347_uc010eql.1_Missense_Mutation_p.E39Q|ZNF347_uc002qbc.1_Missense_Mutation_p.E39Q	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		CTATAATTCTCCAACATCACG	0.517													41	71					0	0	0	0	G	53652521	G	G	53652521	3	3	252	1	0	0	0	0	1	0	0	0	17928	864	30	2	2419	2	ZNF347	19	53652521	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	267367	53652521	5476462	288	46279											
NLRP7	199713	broad.mit.edu	37	chr19	55451377	55451377	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcttcttctcccagtccccGcagatgtcctggatcagcgc	5	12	8	16	2	4	1	1	0	3	1	7	2	6	2	4	1	1	1	4	1	0	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:55451377G>A	uc002qih.3	-	4	886	c.810C>T	c.(808-810)TGC>TGT	p.C270C	NLRP7_uc002qig.3_Silent_p.C270C|NLRP7_uc002qii.3_Silent_p.C270C|NLRP7_uc010esk.2_Silent_p.C270C|NLRP7_uc010esl.2_Silent_p.C298C	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	270	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CCCAGTCCCCGCAGATGTCCT	0.592													28	38					0	0	0	0	A	55451377	A	A	55451377	2	1	252	1	0	0	0	0	0	0	0	1	10536	1079	38	1		1	NLRP7	19	55451377	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1798856	55451377	3677606	289	46280											
U2AF2	11338	broad.mit.edu	37	chr19	56166482	56166482	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcctcagcatgtcggacttCgacgagttcgagcggcagct	7	8	13	13	6	1	0	1	0	0	0	4	4	1	1	1	2	3	4	1	2	0	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr19:56166482C>T	uc002qlu.2	+	1	1067	c.12C>T	c.(10-12)TTC>TTT	p.F4F	U2AF2_uc002qlt.2_Silent_p.F4F	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	4					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		TGTCGGACTTCGACGAGTTCG	0.692													6	15					0	0	0	0	T	56166482	T	T	56166482	2	4	252	1	0	0	0	0	0	0	0	1	16891	883	31	1		1	U2AF2	19	56166482	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	715105	56166482	2962501	290	46281											
SIRPD	128646	broad.mit.edu	37	chr20	1517864	1517864	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atagtttgtgctgtttctctCaggcagggccgagaggcagg	7	11	15	8	1	2	1	1	0	1	1	3	2	2	1	1	4	1	5	1	4	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:1517864C>G	uc002wfi.2	-	3	558	c.514G>C	c.(514-516)GAG>CAG	p.E172Q		NM_178460	NP_848555	Q9H106	SIRPD_HUMAN	signal-regulatory protein delta precursor	172						extracellular region				ovary(1)|kidney(1)|skin(1)	3						CTGTTTCTCTCAGGCAGGGCC	0.602													5	83					0	0	0	0	G	1517864	G	G	1517864	3	3	252	1	0	0	0	0	1	0	0	0	14400	835	29	2	87	2	SIRPD	20	1517864	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08		1517864	61507656	291	46282											
SLC4A11	83959	broad.mit.edu	37	chr20	3210904	3210904	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcgatgatctcctccgtcGacctgccaggaggccatgag	7	7	14	13	3	1	2	0	2	1	0	4	5	2	3	5	3	1	0	5	3	0	0	rs121909388		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:3210904G>A	uc002wig.2	-	12	1514	c.1466C>T	c.(1465-1467)TCG>TTG	p.S489L	SLC4A11_uc010zqe.1_Missense_Mutation_p.S516L|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.S473L	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	489	Membrane (bicarbonate transporter).		S -> L (in CHED2; affects protein processing and transport to the cell surface).		cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						CTCCTCCGTCGACCTGCCAGG	0.637													14	20					0	0	0	0	A	3210904	A	A	3210904	3	1	252	1	0	0	0	0	1	0	0	0	14716	1059	37	1	1241	1	SLC4A11	20	3210904	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1693040	3210904	59814616	292	46283											
NKX2-2	4821	broad.mit.edu	37	chr20	21494272	21494272	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaggtctaagatgtccttGaccgaaaaccccgtctttgt	9	11	10	11	2	2	2	0	1	2	1	3	3	3	2	4	2	1	1	4	2	3	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:21494272G>A	uc002wsi.2	-	1	393	c.36C>T	c.(34-36)GTC>GTT	p.V12V		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	12					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						AGATGTCCTTGACCGAAAACC	0.572													6	51					0	0	0	0	A	21494272	A	A	21494272	2	1	252	1	0	0	0	0	0	0	0	1	10504	1277	45	2		2	NKX2-2	20	21494272	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	18283368	21494272	41531248	293	46284											
PLUNC	51297	broad.mit.edu	37	chr20	31829196	31829196	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acttttctctttcagacttgGccccctccccattcaaggtc	6	14	5	16	0	3	1	2	0	1	1	6	1	4	1	4	2	0	0	4	2	1	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:31829196G>A	uc002wyv.2	+	6	657	c.587G>A	c.(586-588)GGC>GAC	p.G196D	PLUNC_uc002wyt.3_Missense_Mutation_p.G196D|PLUNC_uc002wyu.3_Missense_Mutation_p.G196D	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	196					innate immune response	extracellular region	lipid binding				0						TTCAGACTTGGCCCCCTCCCC	0.542													97	165					0	0	0	0	A	31829196	A	A	31829196	3	1	252	1	0	0	0	0	1	0	0	0	12170	1203	42	4	605	4	PLUNC	20	31829196	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	10334924	31829196	31196324	294	46285											
EIF2S2	8894	broad.mit.edu	37	chr20	32677564	32677564	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttggcacggagctgtgctCgcttgcccgtgacagcctgg	4	10	14	13	3	0	1	0	1	0	0	1	2	0	2	2	3	4	4	2	3	0	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:32677564C>T	uc002xaf.2	-	9	1143	c.974G>A	c.(973-975)CGA>CAA	p.R325Q	EIF2S2_uc002xag.2_Missense_Mutation_p.R322Q|EIF2S2_uc010ges.2_Missense_Mutation_p.R265Q	NM_003908	NP_003899	P20042	IF2B_HUMAN	eukaryotic translation initiation factor 2 beta	325						cytosol|eukaryotic translation initiation factor 2 complex	metal ion binding|protein binding|translation initiation factor activity			large_intestine(1)	1						GAGCTGTGCTCGCTTGCCCGT	0.473													23	40					0	0	0	0	T	32677564	T	T	32677564	3	4	252	1	0	0	0	0	1	0	0	0	5032	884	31	1	31	1	EIF2S2	20	32677564	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	848368	32677564	30347956	295	46286											
LBP	3929	broad.mit.edu	37	chr20	36993299	36993299	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagtcatgagccttcctgagGaacacaacaaaatggtctac	14	8	8	11	0	2	2	1	2	1	0	3	3	3	3	2	2	4	0	2	2	5	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:36993299G>A	uc002xic.1	+	8	849	c.814G>A	c.(814-816)GAA>AAA	p.E272K		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	272					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				CCTTCCTGAGGAACACAACAA	0.468													45	84					0	0	0	0	A	36993299	A	A	36993299	3	1	252	1	0	0	0	0	1	0	0	0	8691	1175	41	2	844	2	LBP	20	36993299	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	4315735	36993299	26032221	296	46287											
CHD6	84181	broad.mit.edu	37	chr20	40050616	40050616	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatgcagctgagggcacttGagcacttgctctcggacttt	7	12	11	11	1	2	2	1	2	1	0	3	3	2	3	0	2	4	5	0	2	0	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:40050616G>C	uc002xka.1	-	31	4837	c.4659C>G	c.(4657-4659)CTC>CTG	p.L1553L		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1553					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GAGGGCACTTGAGCACTTGCT	0.562													14	39					0	0	0	0	C	40050616	C	C	40050616	2	2	252	1	0	0	0	0	0	0	0	1	3344	1277	45	2		2	CHD6	20	40050616	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3057317	40050616	22974904	297	46288											
RBPJL	11317	broad.mit.edu	37	chr20	43942191	43942191	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cacgctacctctctgtggagGatggggcctttgtggccagt	5	11	14	11	1	1	0	0	0	1	0	2	2	1	2	3	5	1	1	3	5	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:43942191G>C	uc002xns.2	+	7	775	c.703G>C	c.(703-705)GAT>CAT	p.D235H	RBPJL_uc002xnt.2_Missense_Mutation_p.D235H	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L	235					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CTCTGTGGAGGATGGGGCCTT	0.453													7	15					0	0	0	0	C	43942191	C	C	43942191	3	2	252	1	0	0	0	0	1	0	0	0	13227	1174	41	2	729	2	RBPJL	20	43942191	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	3891575	43942191	19083329	298	46289											
ZNF335	63925	broad.mit.edu	37	chr20	44577711	44577711	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcttgggccatggcagcatCagccactgctgccaggggag	7	6	16	12	0	1	0	1	0	0	0	1	1	1	1	3	5	4	4	3	5	0	1			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:44577711C>G	uc002xqw.2	-	28	4033	c.3910G>C	c.(3910-3912)GAT>CAT	p.D1304H	ZNF335_uc002xqv.2_Missense_Mutation_p.D416H|ZNF335_uc010zxk.1_Missense_Mutation_p.D1149H	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1304	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				ATGGCAGCATCAGCCACTGCT	0.597													6	32					0	0	0	0	G	44577711	G	G	44577711	3	3	252	1	0	0	0	0	1	0	0	0	17919	826	29	2	122	2	ZNF335	20	44577711	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	635520	44577711	18447809	299	46290											
CD40	958	broad.mit.edu	37	chr20	44757575	44757575	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attttcccgacgatcttcctGgctccaacactgctgctcca	7	12	6	16	2	1	0	0	0	1	0	5	2	5	0	4	1	3	3	4	1	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:44757575G>C	uc002xrg.1	+	9	807	c.730G>C	c.(730-732)GGC>CGC	p.G244R	CD40_uc002xrh.1_3'UTR|CD40_uc002xri.1_3'UTR|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA|CD40_uc002xrl.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	244	Cytoplasmic (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	CGATCTTCCTGGCTCCAACAC	0.597									Immune_Deficiency_with_Hyper-IgM		OREG0025991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	28					0	0	0	0	C	44757575	C	C	44757575	3	2	252	1	0	0	0	0	1	0	0	0	3030	1348	47	4	764	4	CD40	20	44757575	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	179864	44757575	18267945	300	46291											
ARFGEF2	10564	broad.mit.edu	37	chr20	47633821	47633821	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgcgatcaggtacaaattgcTtagaaaacttagtaatatcc	15	11	7	8	2	1	1	1	0	0	1	2	2	2	1	1	1	3	3	1	1	8	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:47633821T>C	uc002xtx.3	+	32	4503	c.4351T>C	c.(4351-4353)TTA>CTA	p.L1451L	ARFGEF2_uc010zyf.1_Silent_p.L744L	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1451					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TACAAATTGCTTAGAAAACTT	0.368													23	32					0	0	0	0	C	47633821	C	C	47633821	2	2	252	1	0	0	0	0	0	0	0	1	853	1606	56	5		5	ARFGEF2	20	47633821	Silent	SNP	T	TCGA-CV-7414-01A-11D-2078-08	2876246	47633821	15391699	301	46292											
ZNF217	7764	broad.mit.edu	37	chr20	52198233	52198233	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgaaagctttgccgcactcgGagcagtgagtgggcttctcc	7	10	13	11	2	1	2	0	2	1	0	3	3	1	3	2	2	3	4	2	2	1	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr20:52198233G>T	uc002xwq.3	-	1	1404	c.1133C>A	c.(1132-1134)TCC>TAC	p.S378Y	ZNF217_uc010gij.1_Missense_Mutation_p.S370Y	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	378	C2H2-type 5.				negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			GCCGCACTCGGAGCAGTGAGT	0.607													6	57					0.00198382	0.00201145	1	0	T	52198233	T	T	52198233	3	4	252	1	0	0	0	0	1	0	0	0	17839	1174	41	2	2029	2	ZNF217	20	52198233	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	4564412	52198233	10827287	302	46293											
KRTAP27-1	643812	broad.mit.edu	37	chr21	31709900	31709900	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacacaatctgtcttcaaaGgttataggattagtgccatg	14	12	8	7	0	3	0	1	0	2	0	3	1	3	1	1	2	2	1	1	2	6	4			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr21:31709900G>T	uc002ynx.1	-	1	113	c.87C>A	c.(85-87)ACC>ACA	p.T29T		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	29						intermediate filament				ovary(2)	2						TGTCTTCAAAGGTTATAGGAT	0.468													44	99					7.05121e-23	7.48292e-23	1	0	T	31709900	T	T	31709900	2	4	252	1	0	0	0	0	0	0	0	1	8584	987	35	4		4	KRTAP27-1	21	31709900	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08		31709900	16419995	303	46294											
MRAP	56246	broad.mit.edu	37	chr21	33686872	33686872	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatttcagctttaacacaGatgaatctcttctgcattca	12	14	5	10	0	4	2	2	1	2	1	5	3	4	2	0	0	3	2	0	0	2	5	rs150983600		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr21:33686872G>T	uc002ypk.2	+	5	404	c.217G>T	c.(217-219)GAT>TAT	p.D73Y	URB1_uc002ypn.2_3'UTR	NM_206898	NP_996781	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	Error:Variant_position_missing_in_Q8TCY5_after_alignment					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding				0						CTTTAACACAGATGAATCTCT	0.378													23	28					3.28513e-13	3.42632e-13	1	0	T	33686872	T	T	33686872	3	4	252	1	0	0	0	0	1	0	0	0	9806	942	33	2	544	2	MRAP	21	33686872	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	1976972	33686872	14443023	304	46295											
ZNF295	49854	broad.mit.edu	37	chr21	43412300	43412300	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgcgccttaacttaatgatCagggccttcttaatttctct	8	15	6	12	2	3	1	1	1	2	0	4	1	3	1	3	1	1	0	3	1	3	5			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr21:43412300C>G	uc002zab.3	-	3	2119	c.1905G>C	c.(1903-1905)CTG>CTC	p.L635L	ZNF295_uc002yzz.3_Intron|ZNF295_uc002yzy.3_Silent_p.L635L|ZNF295_uc002zaa.3_Silent_p.L635L	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	635					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ACTTAATGATCAGGGCCTTCT	0.458													4	81					0	0	0	0	G	43412300	G	G	43412300	2	3	252	1	0	0	0	0	0	0	0	1	17894	813	29	2		2	ZNF295	21	43412300	Silent	SNP	C	TCGA-CV-7414-01A-11D-2078-08	9725428	43412300	4717595	305	46296											
TMPRSS3	64699	broad.mit.edu	37	chr21	43795836	43795836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcacccacctccatctgctCgtggatccagtccaggaagg	8	7	10	16	2	1	0	0	0	1	0	5	2	4	2	5	3	1	2	5	3	1	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr21:43795836C>T	uc002zbb.2	-	12	1537	c.1336G>A	c.(1336-1338)GAG>AAG	p.E446K	TMPRSS3_uc002zay.2_Missense_Mutation_p.E203K|TMPRSS3_uc002zaz.2_Missense_Mutation_p.E319K|TMPRSS3_uc002zba.2_Missense_Mutation_p.E319K|TMPRSS3_uc002zbc.2_Missense_Mutation_p.E445K	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	446	Peptidase S1.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						TCCATCTGCTCGTGGATCCAG	0.582													37	78					0	0	0	0	T	43795836	T	T	43795836	3	4	252	1	0	0	0	0	1	0	0	0	16314	893	31	1	36	1	TMPRSS3	21	43795836	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08	383536	43795836	4334059	306	46297											
ATP6V1E1	529	broad.mit.edu	37	chr22	18083871	18083871	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agggtacctggagaaccagtCcatccagcagcacttggtac	11	7	11	12	0	0	1	0	0	0	1	2	2	2	1	4	3	5	4	4	3	3	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr22:18083871C>A	uc002zmr.1	-	5	540	c.353G>T	c.(352-354)GGA>GTA	p.G118V	ATP6V1E1_uc002zms.1_Intron|ATP6V1E1_uc002zmt.1_Missense_Mutation_p.G96V	NM_001696	NP_001687	P36543	VATE1_HUMAN	vacuolar H+ ATPase E1 isoform a	118					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|cytosol|endosome|proton-transporting two-sector ATPase complex, catalytic domain	protein binding|proton-transporting ATPase activity, rotational mechanism			large_intestine(1)|central_nervous_system(1)	2		all_epithelial(15;0.206)		Lung(27;0.19)		GAGAACCAGTCCATCCAGCAG	0.393													41	69					3.05275e-18	3.20231e-18	1	0	A	18083871	A	A	18083871	3	1	252	1	0	0	0	0	1	0	0	0	1185	855	30	2	347	2	ATP6V1E1	22	18083871	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08		18083871	33220695	307	46298											
SF3A1	10291	broad.mit.edu	37	chr22	30730681	30730681	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttggaatctttgatgaagaTaccctggaaaacagacagcg	14	9	11	7	1	1	4	0	2	1	2	1	6	1	6	1	2	3	1	1	2	5	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr22:30730681T>C	uc003ahl.2	-	16	2416	c.2284A>G	c.(2284-2286)ATC>GTC	p.I762V		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	762	Ubiquitin-like.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						TTGATGAAGATACCCTGGAAA	0.537													26	46					0	0	0	0	C	30730681	C	C	30730681	3	2	252	1	0	0	0	0	1	0	0	0	14211	1406	49	5	101	5	SF3A1	22	30730681	Missense_Mutation	SNP	T	TCGA-CV-7414-01A-11D-2078-08	12646810	30730681	20573885	308	46299											
CSF2RB	1439	broad.mit.edu	37	chr22	37334191	37334191	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccggtcccccaggtcaccaAggaacaatcctgtcccccct	8	6	8	19	1	1	0	1	0	0	0	4	1	4	1	8	3	1	0	8	3	3	0			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr22:37334191A>T	uc003aqa.3	+	14	2558	c.2341A>T	c.(2341-2343)AGG>TGG	p.R781W	CSF2RB_uc003aqc.3_Missense_Mutation_p.R787W	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	781	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	CAGGTCACCAAGGAACAATCC	0.652													15	32					0	0	0	0	T	37334191	T	T	37334191	3	4	252	1	0	0	0	0	1	0	0	0	3952	63	3	5	2391	5	CSF2RB	22	37334191	Missense_Mutation	SNP	A	TCGA-CV-7414-01A-11D-2078-08	6603510	37334191	13970375	309	46300											
WNT7B	7477	broad.mit.edu	37	chr22	46319005	46319005	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctgtctccatgggcttctGatagctgcgcagctgtttga	5	14	12	10	1	3	2	0	2	3	0	4	2	3	2	1	1	3	5	1	1	1	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chr22:46319005G>C	uc003bgo.2	-	4	1155	c.781C>G	c.(781-783)CAG>GAG	p.Q261E	WNT7B_uc010haa.2_Missense_Mutation_p.Q265E	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	261					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		ATGGGCTTCTGATAGCTGCGC	0.647													7	62					0	0	0	0	C	46319005	C	C	46319005	3	2	252	1	0	0	0	0	1	0	0	0	17463	1299	45	2	272	2	WNT7B	22	46319005	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	8984814	46319005	4985561	310	46301											
FAM9B	171483	broad.mit.edu	37	chrX	8995923	8995923	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagacctttacgaattggtCacgtagcagcttcatctctt	10	13	7	11	2	3	1	2	0	1	1	4	2	3	1	1	1	3	3	1	1	3	6			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chrX:8995923C>G	uc011mhu.1	-	6	567	c.478G>C	c.(478-480)GAC>CAC	p.D160H	FAM9B_uc011mhv.1_RNA|FAM9B_uc004csh.2_Missense_Mutation_p.D200H	NM_205849	NP_995321	Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	160						nucleus					0		Hepatocellular(5;0.219)				ACGAATTGGTCACGTAGCAGC	0.358													4	30					0	0	0	0	G	8995923	G	G	8995923	3	3	252	1	0	0	0	0	1	0	0	0	5692	826	29	2	90	2	FAM9B	23	8995923	Missense_Mutation	SNP	C	TCGA-CV-7414-01A-11D-2078-08		8995923	146274637	311	46302											
CXorf21	80231	broad.mit.edu	37	chrX	30578057	30578057	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggaaaatctgttgtcactGaattaatggccatcacctgg	12	11	10	8	0	3	1	2	1	1	0	3	2	3	2	2	3	0	1	2	3	4	2			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chrX:30578057G>T	uc004dcg.1	-	3	692	c.416C>A	c.(415-417)TCA>TAA	p.S139*		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	139										ovary(1)	1						TGTTGTCACTGAATTAATGGC	0.433													36	9					4.23469e-30	4.53361e-30	1	0	T	30578057	T	T	30578057	4	4	252	1	0	0	0	0	0	1	0	0	4118	1294	45	2	493	2	CXorf21	23	30578057	Nonsense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	21582134	30578057	124692503	312	46303											
AR	367	broad.mit.edu	37	chrX	66905872	66905872	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaacagaagtacctgtgcGccagcagaaatgattgcact	14	7	11	9	1	0	3	0	1	0	2	0	4	0	4	2	1	5	3	2	1	4	2	rs137852569		TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chrX:66905872G>A	uc004dwu.1	+	3	2904	c.1789G>A	c.(1789-1791)GCC>ACC	p.A597T	AR_uc011mpd.1_Missense_Mutation_p.A597T|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.A597T|AR_uc004dwv.1_Missense_Mutation_p.A65T	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	596	NR C4-type.|Interaction with HIPK3 (By similarity).|Nuclear receptor.		A -> T (in AIS; abolishes dimerization).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GTACCTGTGCGCCAGCAGAAA	0.413									Androgen_Insensitivity_Syndrome				3	33					0	0	0	0	A	66905872	A	A	66905872	3	1	252	1	0	0	0	0	1	0	0	0	836	1087	38	1	1823	1	AR	23	66905872	Missense_Mutation	SNP	G	TCGA-CV-7414-01A-11D-2078-08	36327815	66905872	88364688	313	46304											
KIAA2022	340533	broad.mit.edu	37	chrX	73964209	73964209	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtagaggcaggagacctctGggatacatcagggtctcttt	9	10	14	8	0	3	2	1	0	2	2	4	4	3	3	1	5	1	2	1	5	2	3			TCGA-CV-7414-01A-11D-2078-08	TCGA-CV-7414-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7137f980-5301-4b18-9664-d887eaced75e	1d18702d-756c-4764-92d5-6ffbd598cc90	g.chrX:73964209G>A	uc004eby.2	-	3	800	c.183C>T	c.(181-183)CCC>CCT	p.P61P		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	61					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GGAGACCTCTGGGATACATCA	0.537													3	9					0	0	0	0	A	73964209	A	A	73964209	2	1	252	1	0	0	0	0	0	0	0	1	8308	1335	47	4		4	KIAA2022	23	73964209	Silent	SNP	G	TCGA-CV-7414-01A-11D-2078-08	7058337	73964209	81306351	314	46305											
PER3	8863	broad.mit.edu	37	chr1	7870006	7870006	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcctggggagcagcgggtcGcaggagcagcttgtcagcat	8	6	17	10	2	1	0	1	0	0	0	2	2	1	2	1	4	6	5	1	4	0	1	rs139242507		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:7870006G>T	uc001aoo.2	+	11	1468	c.1293G>T	c.(1291-1293)TCG>TCT	p.S431S	PER3_uc009vmg.1_Silent_p.S432S|PER3_uc009vmh.1_Silent_p.S432S|PER3_uc001aop.2_Silent_p.S432S|PER3_uc010nzw.1_Silent_p.S113S	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	431					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGCGGGTCGCAGGAGCAGC	0.592													11	34					9.70103e-10	2.26643e-09	1	0	T	7870006	T	T	7870006	2	4	253	1	0	0	0	0	0	0	0	1	11785	1074	38	3		3	PER3	1	7870006	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08		7870006	241380615	1	46306											
PRAMEF12	390999	broad.mit.edu	37	chr1	12837316	12837316	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgagcccctctcagttctGctggagcaagctgaggccac	7	8	11	15	0	2	2	1	2	2	0	3	3	2	3	4	2	4	4	4	2	1	1			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:12837316G>A	uc001aui.2	+	3	1053	c.1026G>A	c.(1024-1026)CTG>CTA	p.L342L		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	342										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCAGTTCTGCTGGAGCAAG	0.587													16	55					0	0	0	0	A	12837316	A	A	12837316	2	1	253	1	0	0	0	0	0	0	0	1	12488	1306	46	4		4	PRAMEF12	1	12837316	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08	4967310	12837316	236413305	2	46307											
PRAMEF1	65121	broad.mit.edu	37	chr1	12855677	12855677	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctctcccagtacccaagcctCggttacctaaagcatctgaa	11	9	6	15	1	2	1	0	1	2	0	4	1	2	1	4	1	4	3	4	1	6	3	rs142654121		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:12855677C>G	uc001auj.1	+	4	1060	c.957C>G	c.(955-957)CTC>CTG	p.L319L		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	319	LRR 1.										0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCAAGCCTCGGTTACCTAA	0.493													23	110					0	0	0	0	G	12855677	G	G	12855677	2	3	253	1	0	0	0	0	0	0	0	1	12485	871	31	3		3	PRAMEF1	1	12855677	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08	18361	12855677	236394944	3	46308											
MAGI3	260425	broad.mit.edu	37	chr1	114184803	114184803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctggagcagaatggaaaatCgggacacactttgactggtg	12	9	13	7	1	1	2	0	1	1	1	2	5	1	5	0	4	1	1	0	4	3	1			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:114184803C>T	uc001edk.2	+	10	1812	c.1631C>T	c.(1630-1632)TCG>TTG	p.S544L	MAGI3_uc001edh.3_Missense_Mutation_p.S569L|MAGI3_uc001edi.3_Missense_Mutation_p.S544L|MAGI3_uc010owm.1_Missense_Mutation_p.S569L|MAGI3_uc001edj.2_Missense_Mutation_p.S265L	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	569					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AATGGAAAATCGGGACACACT	0.493													28	79					0	0	0	0	T	114184803	T	T	114184803	3	4	253	1	0	0	0	0	1	0	0	0	9245	893	31	1	1669	1	MAGI3	1	114184803	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	101329126	114184803	135065818	4	46309											
HMGCS2	3158	broad.mit.edu	37	chr1	120296002	120296002	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagccagccagttcttgggCagagtggctgtggggaaaga	9	7	18	7	0	1	2	0	0	1	2	1	4	1	4	2	5	2	3	2	5	1	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:120296002C>A	uc001eid.2	-	7	1246	c.1195G>T	c.(1195-1197)GCC>TCC	p.A399S	HMGCS2_uc010oxj.1_Missense_Mutation_p.A357S|HMGCS2_uc001eie.2_Missense_Mutation_p.A307S	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	399					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		AGTTCTTGGGCAGAGTGGCTG	0.348													9	23					1.33987e-11	3.15827e-11	1	0	A	120296002	A	A	120296002	3	1	253	1	0	0	0	0	1	0	0	0	7272	710	25	4	343	4	HMGCS2	1	120296002	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	6111199	120296002	128954619	5	46310											
THEM4	117145	broad.mit.edu	37	chr1	151867562	151867562	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaacgtttccaggagccgtCttcacatttcttcataaact	11	13	5	12	2	4	0	2	0	2	0	5	1	5	1	2	1	3	1	2	1	3	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:151867562C>T	uc001ezj.1	-	2	387	c.208G>A	c.(208-210)GAC>AAC	p.D70N	THEM4_uc001ezk.1_RNA	NM_053055	NP_444283	Q5T1C6	THEM4_HUMAN	thioesterase superfamily member 4	70					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|ruffle membrane					0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CAGGAGCCGTCTTCACATTTC	0.433													4	89					0	0	0	0	T	151867562	T	T	151867562	3	4	253	1	0	0	0	0	1	0	0	0	15924	913	32	2	534	2	THEM4	1	151867562	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	31571560	151867562	97383059	6	46311											
TCHHL1	126637	broad.mit.edu	37	chr1	152058810	152058810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgagtctgatctcctccttCtgagcttagatattgtgtct	6	17	9	9	0	4	4	0	3	4	1	6	4	5	4	2	0	1	1	2	0	2	4			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:152058810C>T	uc001ezo.1	-	3	1413	c.1348G>A	c.(1348-1350)GAA>AAA	p.E450K		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	450							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TCTCCTCCTTCTGAGCTTAGA	0.448													18	192					0	0	0	0	T	152058810	T	T	152058810	3	4	253	1	0	0	0	0	1	0	0	0	15767	922	32	2	1370	2	TCHHL1	1	152058810	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	191248	152058810	97191811	7	46312											
CCDC19	25790	broad.mit.edu	37	chr1	159857775	159857775	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accatctccttctgtttcatGatcttctttcgtgtcatcac	6	18	4	13	1	7	1	3	1	4	0	9	1	7	1	2	0	0	1	2	0	0	4			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:159857775G>T	uc001fui.2	-	5	462	c.444C>A	c.(442-444)ATC>ATA	p.I148I	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Silent_p.I63I|CCDC19_uc001ful.2_Silent_p.I63I|CCDC19_uc009wtc.1_Silent_p.I148I	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	148						mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TCTGTTTCATGATCTTCTTTC	0.542													29	54					1.55811e-20	3.73946e-20	1	0	T	159857775	T	T	159857775	2	4	253	1	0	0	0	0	0	0	0	1	2808	1280	45	2		2	CCDC19	1	159857775	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08	7798965	159857775	89392846	8	46313											
SELE	6401	broad.mit.edu	37	chr1	169701064	169701064	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cattcaccgtggccactgcaGgatgtattggtacaggcagc	9	9	12	11	1	1	0	1	0	0	0	1	1	1	1	2	4	3	4	2	4	2	4			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:169701064G>A	uc001ggm.3	-	4	598	c.441C>T	c.(439-441)TCC>TCT	p.S147S	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	147	EGF-like.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GGCCACTGCAGGATGTATTGG	0.438													11	20					0	0	0	0	A	169701064	A	A	169701064	2	1	253	1	0	0	0	0	0	0	0	1	14078	987	35	4		4	SELE	1	169701064	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08	9843289	169701064	79549557	9	46314											
RABGAP1L	9910	broad.mit.edu	37	chr1	174606603	174606603	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atactggaggagatggtcaaGaatcgctctataagatctgc	13	10	11	7	1	3	3	1	0	2	3	4	5	3	4	0	3	2	1	0	3	5	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:174606603G>A	uc001gjx.2	+	14	1996	c.1801G>A	c.(1801-1803)GAA>AAA	p.E601K		NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	601	Rab-GAP TBC.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						AGATGGTCAAGAATCGCTCTA	0.358													16	57					0	0	0	0	A	174606603	A	A	174606603	3	1	253	1	0	0	0	0	1	0	0	0	13030	943	33	2	1851	2	RABGAP1L	1	174606603	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	4905539	174606603	74644018	10	46315											
PRG4	10216	broad.mit.edu	37	chr1	186273956	186273956	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttctgaaaatcaagagtcctCctcctcctcctcctcttcct	7	14	3	17	0	3	2	1	1	2	1	10	2	10	2	7	0	0	0	7	0	3	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:186273956C>G	uc001gru.3	+	6	551	c.500C>G	c.(499-501)TCC>TGC	p.S167C	PRG4_uc001grt.3_Missense_Mutation_p.S126C|PRG4_uc009wyl.2_Intron|PRG4_uc009wym.2_Intron|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	167	Ser-rich.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CAAGAGtcctcctcctcctcc	0.259													4	40					0	0	0	0	G	186273956	G	G	186273956	3	3	253	1	0	0	0	0	1	0	0	0	12543	855	30	2	518	2	PRG4	1	186273956	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	11667353	186273956	62976665	11	46316											
CDC73	79577	broad.mit.edu	37	chr1	193104562	193104562	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagcgctcccttagaaataGgtcttcagcgatctactcaa	12	10	8	11	2	4	1	2	0	2	1	5	3	5	1	1	1	3	1	1	1	6	4			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:193104562G>A	uc001gtb.2	+	4	592	c.349G>A	c.(349-351)GGT>AGT	p.G117S	MIR1278_hsa-mir-1278|MI0006425_5'Flank	NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	117					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49						CTTAGAAATAGGTCTTCAGCG	0.333									Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome				23	42					0	0	0	0	A	193104562	A	A	193104562	3	1	253	1	0	0	0	0	1	0	0	0	3100	1000	35	4	363	4	CDC73	1	193104562	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	6830606	193104562	56146059	12	46317											
ASPM	259266	broad.mit.edu	37	chr1	197115445	197115445	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagacctgcagaagtggctGagagacaggaccggcgggga	11	3	19	8	2	0	4	0	1	0	3	0	8	0	6	2	6	1	2	2	6	1	0			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:197115445G>C	uc001gtu.2	-	1	380	c.123C>G	c.(121-123)CTC>CTG	p.L41L	ASPM_uc001gtv.2_Silent_p.L41L|ASPM_uc001gtw.3_5'UTR	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	41					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						AGAAGTGGCTGAGAGACAGGA	0.373													10	50					0	0	0	0	C	197115445	C	C	197115445	2	2	253	1	0	0	0	0	0	0	0	1	1058	1277	45	2		2	ASPM	1	197115445	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08	4010883	197115445	52135176	13	46318											
OR2M3	127062	broad.mit.edu	37	chr1	248366902	248366902	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgggaaatagcccacttctTctgtgacttcccctccctac	7	12	6	16	1	2	1	0	1	2	0	5	2	4	2	4	1	2	0	4	1	3	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:248366902T>C	uc010pzg.1	+	1	533	c.533T>C	c.(532-534)TTC>TCC	p.F178S		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCCCACTTCTTCTGTGACTTC	0.423													38	182					0	0	0	0	C	248366902	C	C	248366902	3	2	253	1	0	0	0	0	1	0	0	0	11065	1783	62	5	535	5	OR2M3	1	248366902	Missense_Mutation	SNP	T	TCGA-CV-7415-01A-11D-2078-08	51251457	248366902	883719	14	46319											
OR2M7	391196	broad.mit.edu	37	chr1	248487479	248487479	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctcatgagattggtgtatCttagagggtggcaaatggca	10	12	14	5	0	2	2	1	1	2	2	3	3	2	2	0	4	0	3	0	4	3	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr1:248487479C>G	uc010pzk.1	-	1	392	c.392G>C	c.(391-393)AGA>ACA	p.R131T		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTGGTGTATCTTAGAGGGTG	0.438													8	241					0	0	0	0	G	248487479	G	G	248487479	3	3	253	1	0	0	0	0	1	0	0	0	11068	913	32	2	549	2	OR2M7	1	248487479	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	120577	248487479	763142	15	46320											
ANKRD36	375248	broad.mit.edu	37	chr2	97808556	97808556	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacagaaataaaggatggAcaaaaatctgggacaggtat	18	6	11	6	0	1	1	0	0	1	1	1	4	1	4	1	4	0	1	1	4	6	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:97808556A>G	uc010yva.1	+	8	1129	c.885A>G	c.(883-885)GGA>GGG	p.G295G	ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_Intron|ANKRD36_uc002sxo.2_Intron|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	295											0						TAAAGGATGGACAAAAATCTG	0.318													2	3					0	0	0	0	G	97808556	G	G	97808556	2	3	253	1	0	0	0	0	0	0	0	1	665	262	10	5		5	ANKRD36	2	97808556	Silent	SNP	A	TCGA-CV-7415-01A-11D-2078-08		97808556	145390817	16	46321											
SLC9A4	389015	broad.mit.edu	37	chr2	103120006	103120006	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgcccgattcatcgttgtgGggcttggaggggtattgttt	4	15	16	6	2	1	0	1	0	0	0	2	2	1	1	1	5	1	4	1	5	1	6			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:103120006G>A	uc002tbz.3	+	3	1277	c.820G>A	c.(820-822)GGG>AGG	p.G274R		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	274	Helical; Name=H/M6; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CATCGTTGTGGGGCTTGGAGG	0.393													8	46					0	0	0	0	A	103120006	A	A	103120006	3	1	253	1	0	0	0	0	1	0	0	0	14780	1232	43	4	830	4	SLC9A4	2	103120006	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	5311450	103120006	140079367	17	46322											
TTN	7273	broad.mit.edu	37	chr2	179594065	179594065	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agctgccgccttcattggatAcaatgcactggtattcccca	9	11	8	13	1	1	0	1	0	0	0	2	1	2	1	4	2	4	3	4	2	3	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:179594065A>G	uc010zfg.1	-	61	15310	c.15086T>C	c.(15085-15087)GTA>GCA	p.V5029A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V1690A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5956							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATTGGATACAATGCACTG	0.433													11	63					0	0	0	0	G	179594065	G	G	179594065	3	3	253	1	0	0	0	0	1	0	0	0	16803	391	14	5	85907	5	TTN	2	179594065	Missense_Mutation	SNP	A	TCGA-CV-7415-01A-11D-2078-08	76474059	179594065	63605308	18	46323											
NCKAP1	10787	broad.mit.edu	37	chr2	183790481	183790481	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagcatggtatgcatttctCagcaagacataaggaaaaca	17	8	8	8	0	1	1	1	0	1	1	2	2	1	2	0	2	4	4	0	2	5	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:183790481C>G	uc002upc.2	-	31	3738	c.3336G>C	c.(3334-3336)CTG>CTC	p.L1112L	NCKAP1_uc002upb.2_Silent_p.L1118L	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	1112					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			ATGCATTTCTCAGCAAGACAT	0.323													7	78					0	0	0	0	G	183790481	G	G	183790481	2	3	253	1	0	0	0	0	0	0	0	1	10275	813	29	2		2	NCKAP1	2	183790481	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08	4196416	183790481	59408892	19	46324											
ZNF804A	91752	broad.mit.edu	37	chr2	185800736	185800736	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accaagttggggatcaagccCaggggattcacagacacaaa	15	5	11	10	0	2	1	2	0	0	1	2	3	2	3	2	4	1	1	2	4	3	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:185800736C>A	uc002uph.2	+	4	1207	c.613C>A	c.(613-615)CAG>AAG	p.Q205K		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	205						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GGATCAAGCCCAGGGGATTCA	0.418													23	56					1.96895e-08	4.44275e-08	1	0	A	185800736	A	A	185800736	3	1	253	1	0	0	0	0	1	0	0	0	18237	595	21	4	627	4	ZNF804A	2	185800736	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	2010255	185800736	57398637	20	46325											
COL5A2	1290	broad.mit.edu	37	chr2	189898825	189898825	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaaactggcccaatttcaaCgccgaattcctggtctgtgc	10	10	8	13	2	2	0	1	0	1	0	3	1	3	0	3	2	3	0	3	2	4	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr2:189898825C>T	uc002uqk.2	-	54	4746	c.4471G>A	c.(4471-4473)GTT>ATT	p.V1491I	COL5A2_uc010frx.2_Missense_Mutation_p.V1067I	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1491	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAATTTCAACGCCGAATTCC	0.473													7	51					0	0	0	0	T	189898825	T	T	189898825	3	4	253	1	0	0	0	0	1	0	0	0	3712	536	19	1	32	1	COL5A2	2	189898825	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	4098089	189898825	53300548	21	46326											
TMEM22	80723	broad.mit.edu	37	chr3	136573702	136573702	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcggtctaaagttccatctCtagaactgatttttatccgt	10	16	6	9	2	2	2	0	1	2	1	6	2	4	2	2	1	1	1	2	1	5	6			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr3:136573702C>G	uc003erf.3	+	2	614	c.400C>G	c.(400-402)CTA>GTA	p.L134V	TMEM22_uc003erg.3_Missense_Mutation_p.L134V|TMEM22_uc010hub.2_Missense_Mutation_p.L134V	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	134	DUF6 1.|Helical; (Potential).					Golgi apparatus|integral to membrane				ovary(1)	1						AGTTCCATCTCTAGAACTGAT	0.428													31	226					0	0	0	0	G	136573702	G	G	136573702	3	3	253	1	0	0	0	0	1	0	0	0	16209	912	32	2	402	2	TMEM22	3	136573702	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08		136573702	61448728	22	46327											
MECOM	2122	broad.mit.edu	37	chr3	168838959	168838959	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcaccgacatgctgagaGcgaatgtgccgctgaaggtt	9	7	15	10	4	0	2	0	2	0	1	0	5	0	2	2	2	3	4	2	2	2	1			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr3:168838959G>A	uc003ffi.3	-	6	722	c.453C>T	c.(451-453)CGC>CGT	p.R151R	MECOM_uc010hwk.1_Silent_p.R174R|MECOM_uc003ffj.3_Silent_p.R216R|MECOM_uc011bpi.1_Silent_p.R152R|MECOM_uc003ffn.3_Silent_p.R151R|MECOM_uc003ffk.2_Silent_p.R151R|MECOM_uc003ffl.2_Silent_p.R311R|MECOM_uc011bpj.1_Silent_p.R339R|MECOM_uc011bpk.1_Silent_p.R141R|MECOM_uc010hwn.2_Silent_p.R339R	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	151	Interaction with MAPK9, SMAD3 and probably SUV39H1.|C2H2-type 4.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CATGCTGAGAGCGAATGTGCC	0.517													39	22					0	0	0	0	A	168838959	A	A	168838959	2	1	253	1	0	0	0	0	0	0	0	1	9475	958	34	4		4	MECOM	3	168838959	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08	32265257	168838959	29183471	23	46328											
MCF2L2	23101	broad.mit.edu	37	chr3	183017859	183017859	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattttttcttgtttccattGatgaaatcgtcacagaggtg	9	17	8	7	1	2	3	1	2	1	1	4	3	3	3	1	1	0	1	1	1	1	6			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr3:183017859G>A	uc003fli.1	-	11	1329	c.1239C>T	c.(1237-1239)ATC>ATT	p.I413I	MCF2L2_uc003flj.1_Silent_p.I413I|MCF2L2_uc011bqr.1_RNA|MCF2L2_uc003flp.1_3'UTR	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	413	Spectrin.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TGTTTCCATTGATGAAATCGT	0.488													17	104					0	0	0	0	A	183017859	A	A	183017859	2	1	253	1	0	0	0	0	0	0	0	1	9433	1280	45	2		2	MCF2L2	3	183017859	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08	14178900	183017859	15004571	24	46329											
PAK2	5062	broad.mit.edu	37	chr3	196529909	196529909	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcatgccagaacagtgggctCgattactacagacctccaat	12	8	9	12	1	0	2	0	0	0	2	2	3	1	2	3	1	4	2	3	1	4	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr3:196529909C>G	uc003fwy.3	+	4	632	c.310C>G	c.(310-312)CGA>GGA	p.R104G		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	104	GTPase-binding (By similarity).|Autoregulatory region (By similarity).				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		ACAGTGGGCTCGATTACTACA	0.378													4	90					0	0	0	0	G	196529909	G	G	196529909	3	3	253	1	0	0	0	0	1	0	0	0	11455	876	31	3	320	3	PAK2	3	196529909	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	13512050	196529909	1492521	25	46330											
STX18	53407	broad.mit.edu	37	chr4	4426946	4426946	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagtcgctgattttcctgttCaaactgtgaggaaacagaca	12	12	9	8	1	1	3	1	2	0	1	3	4	2	4	1	1	2	2	1	1	3	4			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr4:4426946C>T	uc003gic.2	-	8	790	c.706G>A	c.(706-708)GAA>AAA	p.E236K		NM_016930	NP_058626	Q9P2W9	STX18_HUMAN	syntaxin 18	236	Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|intracellular protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	SNAP receptor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.0534)		TTTTCCTGTTCAAACTGTGAG	0.448													5	33					0	0	0	0	T	4426946	T	T	4426946	3	4	253	1	0	0	0	0	1	0	0	0	15407	835	29	2	317	2	STX18	4	4426946	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08		4426946	186727330	26	46331											
ANKRD17	26057	broad.mit.edu	37	chr4	73957032	73957032	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggttgttgctgattagaatGagctgatgaactcccagaag	12	11	12	6	0	0	6	0	4	0	2	1	6	1	6	1	1	3	4	1	1	4	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr4:73957032G>C	uc003hgp.2	-	29	6430	c.6313C>G	c.(6313-6315)CAT>GAT	p.H2105D	ANKRD17_uc003hgo.2_Missense_Mutation_p.H1992D|ANKRD17_uc003hgq.2_Missense_Mutation_p.H1854D|ANKRD17_uc003hgr.2_Missense_Mutation_p.H2104D	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2105	Ser-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGATTAGAATGAGCTGATGAA	0.498													11	124					0	0	0	0	C	73957032	C	C	73957032	3	2	253	1	0	0	0	0	1	0	0	0	646	1290	45	2	1522	2	ANKRD17	4	73957032	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	69530086	73957032	117197244	27	46332											
TACR3	6870	broad.mit.edu	37	chr4	104579371	104579371	+	Splice_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cataatagagaattaacttaCgtgaaatgttgtttgggacc	14	13	9	5	1	0	2	0	1	0	1	0	4	0	3	1	1	2	2	1	1	6	6			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr4:104579371C>T	uc003hxe.1	-	2	880	c.737_splice	c.e2+1	p.T246_splice		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3							integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AATTAACTTACGTGAAATGTT	0.393													16	50					0	0	0	0	T	104579371	T	T	104579371	5	4	253	1	0	0	0	0	0	0	1	0	15573	550	19	1	675	1	TACR3	4	104579371	Splice_Site	SNP	C	TCGA-CV-7415-01A-11D-2078-08	30622339	104579371	86574905	28	46333											
PCDH10	57575	broad.mit.edu	37	chr4	134072862	134072862	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttctatcaactctgagaacGgctacttgtacgccctgcgc	8	12	8	13	3	3	1	1	1	2	1	3	2	3	1	1	1	5	2	1	1	5	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr4:134072862G>A	uc003iha.2	+	1	2393	c.1567G>A	c.(1567-1569)GGC>AGC	p.G523S	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.G523S	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	523	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CTCTGAGAACGGCTACTTGTA	0.602													17	68					0	0	0	0	A	134072862	A	A	134072862	3	1	253	1	0	0	0	0	1	0	0	0	11561	1116	39	1	1569	1	PCDH10	4	134072862	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	29493491	134072862	57081414	29	46334											
FSTL5	56884	broad.mit.edu	37	chr4	163032465	163032465	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgataggatttaaggccAtatcctccttctttggttgg	7	15	11	8	0	1	1	0	1	1	0	3	2	3	2	3	5	0	2	3	5	3	7			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr4:163032465A>G	uc003iqh.2	-	2	520	c.84T>C	c.(82-84)TAT>TAC	p.Y28Y	FSTL5_uc003iqi.2_Silent_p.Y28Y|FSTL5_uc010iqv.2_Silent_p.Y28Y	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	28						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATTTAAGGCCATATCCTCCTT	0.408													14	116					0	0	0	0	G	163032465	G	G	163032465	2	3	253	1	0	0	0	0	0	0	0	1	6114	224	8	5		5	FSTL5	4	163032465	Silent	SNP	A	TCGA-CV-7415-01A-11D-2078-08	28959603	163032465	28121811	30	46335											
FBN2	2201	broad.mit.edu	37	chr5	127595501	127595501	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggctgtccatgtcgacactCtctaggctgatctgttcaac	7	12	10	12	1	3	1	1	1	2	0	6	2	4	1	1	2	1	3	1	2	2	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:127595501C>T	uc003kuu.2	-	65	8824	c.8385G>A	c.(8383-8385)GAG>GAA	p.E2795E		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2795					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGTCGACACTCTCTAGGCTGA	0.537													11	68					0	0	0	0	T	127595501	T	T	127595501	2	4	253	1	0	0	0	0	0	0	0	1	5735	912	32	2		2	FBN2	5	127595501	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08		127595501	53319759	31	46336											
PCDHA10	56139	broad.mit.edu	37	chr5	140237196	140237196	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaggtgtacgcgctgcagccGctggaccacgaggagctgga	9	5	16	11	4	0	0	0	0	0	0	0	4	0	3	2	4	4	5	2	4	2	1			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:140237196G>A	uc003lhx.2	+	1	1563	c.1563G>A	c.(1561-1563)CCG>CCA	p.P521P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.P521P|PCDHA10_uc011dad.1_Silent_p.P521P	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	521	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGCAGCCGCTGGACCACG	0.677													9	82					0	0	0	0	A	140237196	A	A	140237196	2	1	253	1	0	0	0	0	0	0	0	1	11574	1074	38	1		1	PCDHA10	5	140237196	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08	12641695	140237196	40678064	32	46337											
PCDHGC3	5098	broad.mit.edu	37	chr5	140856119	140856119	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaatgaaattggagattagcGaggccgtggctccggggacg	11	7	16	7	4	0	2	0	1	0	1	1	5	1	3	2	5	1	1	2	5	3	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:140856119G>A	uc003lkv.1	+	1	551	c.436G>A	c.(436-438)GAG>AAG	p.E146K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Missense_Mutation_p.E146K|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	146	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGATTAGCGAGGCCGTGGC	0.547													7	44					0	0	0	0	A	140856119	A	A	140856119	3	1	253	1	0	0	0	0	1	0	0	0	11623	1059	37	1	438	1	PCDHGC3	5	140856119	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	618923	140856119	40059141	33	46338											
CDHR2	54825	broad.mit.edu	37	chr5	176011455	176011455	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctgggacgcggaccagacgGaagccaacaaccgcatcagc	12	2	12	15	4	1	1	1	0	0	1	1	4	1	4	4	3	4	1	4	3	3	0			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:176011455G>A	uc003mem.1	+	19	2239	c.2173G>A	c.(2173-2175)GAA>AAA	p.E725K	CDHR2_uc003men.1_Missense_Mutation_p.E725K	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	725	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GGACCAGACGGAAGCCAACAA	0.637													10	78					0	0	0	0	A	176011455	A	A	176011455	3	1	253	1	0	0	0	0	1	0	0	0	3134	1175	41	2	2243	2	CDHR2	5	176011455	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	35155336	176011455	4903805	34	46339											
F12	2161	broad.mit.edu	37	chr5	176829658	176829658	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcgctccagggagaggaacgGtacctgcgcctcctgcagga	8	5	15	13	3	0	1	0	0	0	1	2	4	2	3	4	4	4	3	4	4	2	1			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:176829658G>A	uc003mgo.3	-	13	1622	c.1573C>T	c.(1573-1575)CCG>TCG	p.P525S	PFN3_uc003mgl.2_5'Flank|F12_uc011dfy.1_Silent_p.Y55Y|F12_uc003mgn.3_Silent_p.Y55Y|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	525	Peptidase S1.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGAGGAACGGTACCTGCGCC	0.662									Hereditary_Angioedema				7	23					0	0	0	0	A	176829658	A	A	176829658	3	1	253	1	0	0	0	0	1	0	0	0	5364	1261	44	4	282	4	F12	5	176829658	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	818203	176829658	4085602	35	46340											
AGXT2L2	85007	broad.mit.edu	37	chr5	177649532	177649532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgcctacccggccaaagcCaacctggatctcatctgcaa	10	8	7	16	1	2	0	1	0	2	0	3	1	2	1	5	2	5	1	5	2	4	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr5:177649532C>T	uc003miz.2	-	8	1003	c.751G>A	c.(751-753)GGC>AGC	p.G251S	AGXT2L2_uc003miy.2_Intron|AGXT2L2_uc003mjc.2_Missense_Mutation_p.G210S|AGXT2L2_uc003mja.2_RNA|AGXT2L2_uc003mjb.2_Intron|AGXT2L2_uc003mjd.1_Missense_Mutation_p.G109S	NM_153373	NP_699204	Q8IUZ5	AT2L2_HUMAN	alanine-glyoxylate aminotransferase 2-like 2	251						mitochondrion	pyridoxal phosphate binding|transaminase activity			pancreas(1)	1	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.181)|all cancers(165;0.235)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	CGGCCAAAGCCAACCTGGATC	0.488													12	45					0	0	0	0	T	177649532	T	T	177649532	3	4	253	1	0	0	0	0	1	0	0	0	407	594	21	4	621	4	AGXT2L2	5	177649532	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	819874	177649532	3265728	36	46341											
GSTA1	2938	broad.mit.edu	37	chr6	52662432	52662432	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agattttataaatttctcttCaaactggaagcagaaacagt	16	13	6	6	0	2	2	1	0	1	2	3	3	2	3	0	1	3	1	0	1	6	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr6:52662432C>T	uc003paz.2	-	3	203	c.91G>A	c.(91-93)GAA>AAA	p.E31K		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	31	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	AATTTCTCTTCAAACTGGAAG	0.368													6	43					0	0	0	0	T	52662432	T	T	52662432	3	4	253	1	0	0	0	0	1	0	0	0	6869	835	29	2	597	2	GSTA1	6	52662432	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08		52662432	118452635	37	46342											
LAMB4	22798	broad.mit.edu	37	chr7	107752371	107752371	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatggaaatctagagtcacaGatgaagcatttttgttcccc	12	13	8	8	0	2	3	1	1	1	2	3	4	3	4	2	1	1	2	2	1	4	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr7:107752371G>A	uc010ljo.1	-	4	297	c.213C>T	c.(211-213)ATC>ATT	p.I71I	LAMB4_uc003vey.2_Silent_p.I71I	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	71	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TAGAGTCACAGATGAAGCATT	0.348													13	86					0	0	0	0	A	107752371	A	A	107752371	2	1	253	1	0	0	0	0	0	0	0	1	8653	932	33	2		2	LAMB4	7	107752371	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08		107752371	51386292	38	46343											
THAP5	168451	broad.mit.edu	37	chr7	108204640	108204640	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaacctagttattctataTcatagtgacttcatatgttg	13	17	5	6	0	3	1	2	1	1	0	3	1	3	1	1	0	1	2	1	0	8	10			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr7:108204640T>A	uc003vfm.2	-	3	1337	c.1183A>T	c.(1183-1185)ATA>TTA	p.I395L	THAP5_uc003vfl.2_Missense_Mutation_p.I353L	NM_001130475	NP_001123947	Q7Z6K1	THAP5_HUMAN	THAP domain containing 5 isoform 1	395					cell cycle|negative regulation of cell cycle	nucleus	DNA binding|metal ion binding|protease binding				0						TTATTCTATATCATAGTGACT	0.328													14	22					0	0	0	0	A	108204640	A	A	108204640	3	1	253	1	0	0	0	0	1	0	0	0	15913	1435	50	5	8	5	THAP5	7	108204640	Missense_Mutation	SNP	T	TCGA-CV-7415-01A-11D-2078-08	452269	108204640	50934023	39	46344											
PEX2	5828	broad.mit.edu	37	chr8	77895656	77895657	+	Frame_Shift_Ins	INS	-	A	A																															cacatcctatggtgtgaggcINSatggtgggccactctccaca																										TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr8:77895656_77895657insA	uc003yax.2	-	4	1216_1217	c.758_759insT	c.(757-759)ATGfs	p.M253fs	PEX2_uc003yay.2_Frame_Shift_Ins_p.M253fs|PEX2_uc003yaz.2_Frame_Shift_Ins_p.M253fs	NM_000318	NP_000309	P28328	PEX2_HUMAN	peroxin 2	253	RING-type.				peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			ovary(1)	1						TGGTGTGAGGCATGGTGGGCCA	0.436													---	---	---								A	77895657	A	A	77895656	7	5	253	1	0	1	1	0	0	0	0	0	11800	710	25	0	162	0	PEX2	8	77895656	Frame_Shift_Ins	INS	-	TCGA-CV-7415-01A-11D-2078-08		77895656	68468366	40	46345											
PKHD1L1	93035	broad.mit.edu	37	chr8	110448632	110448632	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaggtattagttggaaatGaaacctgcaatgtgattgaa	16	11	10	4	0	0	3	0	3	0	0	0	4	0	4	1	2	2	3	1	2	7	4			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr8:110448632G>T	uc003yne.2	+	30	3675	c.3571G>T	c.(3571-3573)GAA>TAA	p.E1191*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1191	Extracellular (Potential).|IPT/TIG 5.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGTTGGAAATGAAACCTGCAA	0.358										HNSCC(38;0.096)			22	36					7.41877e-09	1.70309e-08	1	0	T	110448632	T	T	110448632	4	4	253	1	0	0	0	0	0	1	0	0	12027	1291	45	2	3689	2	PKHD1L1	8	110448632	Nonsense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	32552976	110448632	35915390	41	46346											
EIF2C2	27161	broad.mit.edu	37	chr8	141566084	141566084	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgattccaaattcacggaCgtatggatctgtgttgaaac	12	12	9	8	2	2	2	1	2	1	0	3	4	3	4	1	2	1	2	1	2	3	4			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr8:141566084C>T	uc003yvn.2	-	10	1220	c.1180G>A	c.(1180-1182)GTC>ATC	p.V394I	EIF2C2_uc010men.2_Missense_Mutation_p.V317I|EIF2C2_uc010meo.2_Missense_Mutation_p.V394I	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	394					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			AATTCACGGACGTATGGATCT	0.562													10	80					0	0	0	0	T	141566084	T	T	141566084	3	4	253	1	0	0	0	0	1	0	0	0	5028	536	19	1	1439	1	EIF2C2	8	141566084	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	31117452	141566084	4797938	42	46347											
C9orf93	203238	broad.mit.edu	37	chr9	15920346	15920346	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagagaaggaaatgacatctCatcgaagtcacattgcagcc	15	8	9	9	1	2	2	2	1	1	1	4	5	2	3	1	1	2	1	1	1	4	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr9:15920346C>T	uc003zmd.2	+	25	3994	c.3679C>T	c.(3679-3681)CAT>TAT	p.H1227Y	C9orf93_uc003zme.2_Missense_Mutation_p.H1142Y|C9orf93_uc011lmu.1_Missense_Mutation_p.H1235Y	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	1227	Potential.										0				GBM - Glioblastoma multiforme(50;4.84e-07)		AATGACATCTCATCGAAGTCA	0.343													11	30					0	0	0	0	T	15920346	T	T	15920346	3	4	253	1	0	0	0	0	1	0	0	0	2518	826	29	2	3773	2	C9orf93	9	15920346	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08		15920346	125293085	43	46348											
PRUNE2	158471	broad.mit.edu	37	chr9	79321541	79321541	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgtcactaaaaggattagtAtagtgtgtttccacgggctc	10	14	10	7	1	1	0	1	0	0	0	3	1	2	1	1	2	0	3	1	2	5	6			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr9:79321541A>G	uc010mpk.2	-	8	5773	c.5649T>C	c.(5647-5649)TAT>TAC	p.Y1883Y	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1883					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AAGGATTAGTATAGTGTGTTT	0.473													17	14					0	0	0	0	G	79321541	G	G	79321541	2	3	253	1	0	0	0	0	0	0	0	1	12703	456	16	5		5	PRUNE2	9	79321541	Silent	SNP	A	TCGA-CV-7415-01A-11D-2078-08	63401195	79321541	61891890	44	46349											
TLE4	7091	broad.mit.edu	37	chr9	82334979	82334979	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacagggataactacatcCgttcctgcagattgctccct	11	10	8	12	1	0	2	0	0	0	2	3	3	3	3	3	1	5	3	3	1	3	4			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr9:82334979C>T	uc004ald.2	+	17	2533	c.1684C>T	c.(1684-1686)CGT>TGT	p.R562C	TLE4_uc004alc.2_Missense_Mutation_p.R537C|TLE4_uc010mpr.2_Missense_Mutation_p.R416C|TLE4_uc004ale.2_Missense_Mutation_p.R174C|TLE4_uc011lsq.1_Missense_Mutation_p.R505C|TLE4_uc010mps.2_Missense_Mutation_p.R461C|TLE4_uc004alf.2_Missense_Mutation_p.R476C	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						TAACTACATCCGTTCCTGCAG	0.463													8	42					0	0	0	0	T	82334979	T	T	82334979	3	4	253	1	0	0	0	0	1	0	0	0	16007	652	23	1	1671	1	TLE4	9	82334979	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	3013438	82334979	58878452	45	46350											
CEP110	11064	broad.mit.edu	37	chr9	123852644	123852644	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggctttgataaaatctctGaacctttcactttctaaaga	12	16	5	8	0	3	3	1	2	2	1	4	3	3	3	1	1	1	1	1	1	5	6			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr9:123852644G>C	uc004bkx.1	+	2	340	c.309G>C	c.(307-309)CTG>CTC	p.L103L	CEP110_uc004bkw.2_Silent_p.L103L	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	103					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						TAAAATCTCTGAACCTTTCAC	0.333													10	98					0	0	0	0	C	123852644	C	C	123852644	2	2	253	1	0	0	0	0	0	0	0	1	3260	1277	45	2		2	CEP110	9	123852644	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08	41517665	123852644	17360787	46	46351											
FBXO18	84893	broad.mit.edu	37	chr10	5948405	5948405	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaagatgctggggacgtggGtcctgatcccattcctgact	7	10	12	12	1	0	3	0	2	0	1	3	4	3	4	4	3	1	1	4	3	1	1			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:5948405G>A	uc001iis.2	+	3	658	c.563G>A	c.(562-564)GGT>GAT	p.G188D	FBXO18_uc001iir.2_Missense_Mutation_p.G114D|FBXO18_uc009xig.2_Missense_Mutation_p.G114D|FBXO18_uc001iit.2_Missense_Mutation_p.G239D	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	188					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						GGGGACGTGGGTCCTGATCCC	0.448													5	19					0	0	0	0	A	5948405	A	A	5948405	3	1	253	1	0	0	0	0	1	0	0	0	5763	1261	44	4	735	4	FBXO18	10	5948405	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08		5948405	129586342	47	46352											
APBB1IP	54518	broad.mit.edu	37	chr10	26785285	26785285	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctaatccacccagagctgAatttaactacagtgtggggt	11	10	9	11	0	0	2	0	1	0	1	1	2	1	2	3	2	3	1	3	2	4	4			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:26785285A>T	uc001iss.2	+	4	446	c.125A>T	c.(124-126)GAA>GTA	p.E42V	APBB1IP_uc001isr.2_Missense_Mutation_p.E42V|APBB1IP_uc009xks.1_Missense_Mutation_p.E42V	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	42					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CCCAGAGCTGAATTTAACTAC	0.343													18	56					0	0	0	0	T	26785285	T	T	26785285	3	4	253	1	0	0	0	0	1	0	0	0	760	246	9	5	131	5	APBB1IP	10	26785285	Missense_Mutation	SNP	A	TCGA-CV-7415-01A-11D-2078-08	20836880	26785285	108749462	48	46353											
PARD3	56288	broad.mit.edu	37	chr10	34408630	34408630	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgcacctccacggacacCgagtgtcgcccgctctgcgt	6	8	10	17	5	2	0	0	0	2	0	4	2	3	1	4	1	2	2	4	1	0	0			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:34408630C>T	uc010qej.1	-	24	3588	c.3588G>A	c.(3586-3588)TCG>TCA	p.S1196S	PARD3_uc010qek.1_Silent_p.S1193S|PARD3_uc010qel.1_Silent_p.S1159S|PARD3_uc010qem.1_Silent_p.S1180S|PARD3_uc010qen.1_Silent_p.S1150S|PARD3_uc010qeo.1_Silent_p.S1113S|PARD3_uc010qep.1_Silent_p.S1106S|PARD3_uc010qeq.1_Silent_p.S1084S	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1196					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CCACGGACACCGAGTGTCGCC	0.617													5	11					0	0	0	0	T	34408630	T	T	34408630	2	4	253	1	0	0	0	0	0	0	0	1	11497	639	23	1		1	PARD3	10	34408630	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08	7623345	34408630	101126117	49	46354											
JMJD1C	221037	broad.mit.edu	37	chr10	64974590	64974590	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caacagacttccgcttctctGcttcttcatgttttttatct	6	19	4	12	1	4	1	1	0	3	1	6	1	5	1	1	0	2	3	1	0	2	7			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:64974590G>C	uc001jmn.2	-	8	1637	c.1337C>G	c.(1336-1338)GCA>GGA	p.A446G	JMJD1C_uc001jml.2_Missense_Mutation_p.A227G|JMJD1C_uc001jmm.2_Missense_Mutation_p.A158G|JMJD1C_uc010qiq.1_Missense_Mutation_p.A264G|JMJD1C_uc009xpi.2_Missense_Mutation_p.A264G|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_Missense_Mutation_p.A158G	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	446					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CCGCTTCTCTGCTTCTTCATG	0.388													29	42					0	0	0	0	C	64974590	C	C	64974590	3	2	253	1	0	0	0	0	1	0	0	0	7989	1319	46	4	6361	4	JMJD1C	10	64974590	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	30565960	64974590	70560157	50	46355											
CTNNA3	29119	broad.mit.edu	37	chr10	67726429	67726429	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agctttaacttgactgcagaTtttcagttggtgggagtaga	10	14	12	5	0	1	3	1	1	0	2	1	4	1	4	0	2	3	4	0	2	2	7			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:67726429T>A	uc009xpn.1	-	17	2464	c.2341A>T	c.(2341-2343)ATC>TTC	p.I781F	CTNNA3_uc001jmw.2_Missense_Mutation_p.I781F	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	781					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TGACTGCAGATTTTCAGTTGG	0.428													14	46					0	0	0	0	A	67726429	A	A	67726429	3	1	253	1	0	0	0	0	1	0	0	0	4031	1493	52	5	354	5	CTNNA3	10	67726429	Missense_Mutation	SNP	T	TCGA-CV-7415-01A-11D-2078-08	2751839	67726429	67808318	51	46356											
GRID1	2894	broad.mit.edu	37	chr10	87614310	87614310	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtgccaaggatttcaaactgGacatagggattcgaactgtc	12	10	11	8	1	1	0	1	0	0	0	3	4	1	3	1	3	3	0	1	3	4	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:87614310G>C	uc001kdl.1	-	8	1277	c.1176C>G	c.(1174-1176)GTC>GTG	p.V392V	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	392	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TTTCAAACTGGACATAGGGAT	0.498										Multiple Myeloma(13;0.14)			10	34					0	0	0	0	C	87614310	C	C	87614310	2	2	253	1	0	0	0	0	0	0	0	1	6810	1161	41	2		2	GRID1	10	87614310	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08	19887881	87614310	47920437	52	46357											
WAPAL	23063	broad.mit.edu	37	chr10	88259533	88259533	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattgctttctgggggaggCtgcaaggagggtgatggagc	7	10	18	6	0	2	1	1	1	1	0	2	4	2	4	0	6	3	3	0	6	1	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:88259533C>T	uc001kdo.2	-	3	1909	c.1467G>A	c.(1465-1467)CAG>CAA	p.Q489Q	WAPAL_uc001kdn.2_Silent_p.Q532Q|WAPAL_uc009xsw.2_Silent_p.Q489Q	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	489	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						CTGGGGGAGGCTGCAAGGAGG	0.358													18	63					0	0	0	0	T	88259533	T	T	88259533	2	4	253	1	0	0	0	0	0	0	0	1	17316	796	28	4		4	WAPAL	10	88259533	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08	645223	88259533	47275214	53	46358											
HPS6	79803	broad.mit.edu	37	chr10	103826369	103826369	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatcttcgtctgctttcaGccttgggtctgttttgtgtg	3	18	12	8	1	4	0	1	0	3	0	5	1	4	1	1	2	2	2	1	2	1	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:103826369G>A	uc001kuj.2	+	1	1223	c.1138G>A	c.(1138-1140)GCC>ACC	p.A380T		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	380						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		TCTGCTTTCAGCCTTGGGTCT	0.582									Hermansky-Pudlak_syndrome				5	39					0	0	0	0	A	103826369	A	A	103826369	3	1	253	1	0	0	0	0	1	0	0	0	7382	971	34	4	1140	4	HPS6	10	103826369	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	15566836	103826369	31708378	54	46359											
TAF5	6877	broad.mit.edu	37	chr10	105133180	105133180	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcagcctacaaccaacaaGgagatcccacaatgtatgaa	16	7	7	11	0	1	2	1	1	0	1	2	3	2	2	3	1	4	1	3	1	7	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr10:105133180G>A	uc001kwv.2	+	2	648	c.625G>A	c.(625-627)GGA>AGA	p.G209R	TAF5_uc010qqq.1_Missense_Mutation_p.G209R	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	209					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		CAACCAACAAGGAGATCCCAC	0.413													8	87					0	0	0	0	A	105133180	A	A	105133180	3	1	253	1	0	0	0	0	1	0	0	0	15594	1001	35	4	631	4	TAF5	10	105133180	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	1306811	105133180	30401567	55	46360											
APBB1	322	broad.mit.edu	37	chr11	6425033	6425033	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcggaatccgtctcgaaggcGttggggttccagaaggaatc	9	9	14	9	4	1	1	0	0	1	1	6	4	3	3	2	5	0	2	2	5	4	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr11:6425033G>A	uc001mdb.1	-	3	841	c.741C>T	c.(739-741)AAC>AAT	p.N247N	APBB1_uc001mcz.1_5'Flank|APBB1_uc001mdd.3_Silent_p.N27N|APBB1_uc001mda.2_Intron|APBB1_uc001mdc.1_Silent_p.N247N|APBB1_uc010rab.1_5'Flank|APBB1_uc010rac.1_5'Flank|APBB1_uc010rad.1_5'Flank|APBB1_uc010rae.1_Silent_p.N12N|APBB1_uc010raf.1_Translation_Start_Site|APBB1_uc009yfa.2_Translation_Start_Site|APBB1_uc009yey.2_Translation_Start_Site|APBB1_uc010rag.1_Translation_Start_Site|APBB1_uc009yfb.2_Translation_Start_Site|APBB1_uc001mde.2_Translation_Start_Site|APBB1_uc010rah.1_Translation_Start_Site	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	247					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		TCTCGAAGGCGTTGGGGTTCC	0.617													17	14					0	0	0	0	A	6425033	A	A	6425033	2	1	253	1	0	0	0	0	0	0	0	1	759	1136	40	1		1	APBB1	11	6425033	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08		6425033	128581483	56	46361											
DCHS1	8642	broad.mit.edu	37	chr11	6646039	6646039	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accgttggcacctgagtcccGatcagtggcagagacggaga	10	6	14	11	3	1	3	1	1	0	2	2	6	2	3	3	3	0	3	3	3	0	1	rs141901540		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr11:6646039G>A	uc001mem.1	-	20	7617	c.7207C>T	c.(7207-7209)CGG>TGG	p.R2403W		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2403	Cadherin 23.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTGAGTCCCGATCAGTGGCA	0.557													6	9					0	0	0	0	A	6646039	A	A	6646039	3	1	253	1	0	0	0	0	1	0	0	0	4304	1057	37	1	2697	1	DCHS1	11	6646039	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	221006	6646039	128360477	57	46362											
GALNT8	26290	broad.mit.edu	37	chr12	4855415	4855415	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaggagagaacgtggagctTagcctgagggtgggtacatt	10	8	18	5	1	0	2	0	1	0	1	0	6	0	5	1	5	4	2	1	5	3	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr12:4855415T>C	uc001qne.1	+	6	1256	c.1164T>C	c.(1162-1164)CTT>CTC	p.L388L		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	388	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						ACGTGGAGCTTAGCCTGAGGG	0.498													4	45					0	0	0	0	C	4855415	C	C	4855415	2	2	253	1	0	0	0	0	0	0	0	1	6254	1741	61	5		5	GALNT8	12	4855415	Silent	SNP	T	TCGA-CV-7415-01A-11D-2078-08		4855415	128996480	58	46363											
CD163L1	283316	broad.mit.edu	37	chr12	7559320	7559320	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acatcccaactgcttgcataCgacatcagctgcagcattgt	11	10	7	13	1	1	0	1	0	0	0	2	1	2	0	1	0	7	5	1	0	2	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr12:7559320C>T	uc001qsy.2	-	5	921	c.895G>A	c.(895-897)GTA>ATA	p.V299I	CD163L1_uc010sge.1_Missense_Mutation_p.V309I	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	299	SRCR 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TGCTTGCATACGACATCAGCT	0.522													22	55					0	0	0	0	T	7559320	T	T	7559320	3	4	253	1	0	0	0	0	1	0	0	0	2983	536	19	1	3526	1	CD163L1	12	7559320	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	2703905	7559320	126292575	59	46364											
BRAP	8315	broad.mit.edu	37	chr12	112082288	112082288	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggaggacttggttggcTcgcaaacacttgttcatttc	8	13	11	9	1	1	0	1	0	0	0	3	2	1	2	0	4	2	5	0	4	1	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr12:112082288T>C	uc001tsn.3	-	12	1688	c.1494A>G	c.(1492-1494)CGA>CGG	p.R498R	BRAP_uc010syh.1_Silent_p.R319R|BRAP_uc009zvv.2_Silent_p.R468R	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	498	Potential.				MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						CTTGGTTGGCTCGCAAACACT	0.483													20	78					0	0	0	0	C	112082288	C	C	112082288	2	2	253	1	0	0	0	0	0	0	0	1	1502	1538	54	5		5	BRAP	12	112082288	Silent	SNP	T	TCGA-CV-7415-01A-11D-2078-08	104522968	112082288	21769607	60	46365											
RPLP0	6175	broad.mit.edu	37	chr12	120636708	120636708	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gtggtgatacctaaagcctgGaaaaaggaggtcttctcggg	11	9	14	7	1	2	1	0	1	2	0	3	3	2	3	2	5	2	0	2	5	5	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr12:120636708G>C	uc001txp.2	-	5	651	c.414C>G	c.(412-414)TTC>TTG	p.F138L	RPLP0_uc001txq.2_Missense_Mutation_p.F138L|RPLP0_uc001txr.2_Missense_Mutation_p.F138L|uc001txs.1_5'Flank	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	138					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTAAAGCCTGGAAAAAGGAGG	0.567													6	18					0	0	0	0	C	120636708	C	C	120636708	3	2	253	1	0	0	0	0	1	0	0	0	13669	1165	41	2	555	2	RPLP0	12	120636708	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	8554420	120636708	13215187	61	46366											
SBNO1	55206	broad.mit.edu	37	chr12	123812541	123812541	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaagaaccaacaggacataAgtttttggctttatgacact	14	12	8	7	0	0	3	0	2	0	1	0	4	0	4	1	2	2	2	1	2	5	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr12:123812541A>C	uc010tap.1	-	10	1330	c.1330T>G	c.(1330-1332)TTA>GTA	p.L444V	SBNO1_uc010tao.1_Missense_Mutation_p.L443V|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.L444V|SBNO1_uc001ueu.2_Missense_Mutation_p.L443V|SBNO1_uc001uev.2_Missense_Mutation_p.L442V|SBNO1_uc009zxy.1_Missense_Mutation_p.L409V	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	444							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ACAGGACATAAGTTTTTGGCT	0.368													14	70					0	0	0	0	C	123812541	C	C	123812541	3	2	253	1	0	0	0	0	1	0	0	0	13927	69	3	5	2939	5	SBNO1	12	123812541	Missense_Mutation	SNP	A	TCGA-CV-7415-01A-11D-2078-08	3175833	123812541	10039354	62	46367											
MTUS2	23281	broad.mit.edu	37	chr13	29599504	29599504	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaagacattgccagaccaCgctgtcccggcagctttccc	9	7	9	16	2	0	3	0	0	0	3	2	3	2	3	4	1	2	3	4	1	1	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr13:29599504C>T	uc001usl.3	+	1	757	c.699C>T	c.(697-699)CAC>CAT	p.H233H		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	223						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TGCCAGACCACGCTGTCCCGG	0.587													6	9					0	0	0	0	T	29599504	T	T	29599504	2	4	253	1	0	0	0	0	0	0	0	1	10019	535	19	1		1	MTUS2	13	29599504	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08		29599504	85570374	63	46368											
MYO16	23026	broad.mit.edu	37	chr13	109318469	109318469	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacggacatgctacaggaCgcgattatccaccacaatga	13	7	8	13	3	1	1	1	1	0	0	2	4	2	3	2	2	2	1	2	2	3	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr13:109318469C>T	uc001vqt.1	+	2	324	c.198C>T	c.(196-198)GAC>GAT	p.D66D	MYO16_uc010agk.1_Silent_p.D88D	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	66	ANK 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TGCTACAGGACGCGATTATCC	0.428													4	16					0	0	0	0	T	109318469	T	T	109318469	2	4	253	1	0	0	0	0	0	0	0	1	10117	535	19	1		1	MYO16	13	109318469	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08	79718965	109318469	5851409	64	46369											
MMP14	4323	broad.mit.edu	37	chr14	23313687	23313687	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccatcaacactgcctacgaGaggaaggatggcaaattcgt	13	8	10	10	2	1	1	1	0	0	1	3	4	2	3	2	3	3	1	2	3	4	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr14:23313687G>C	uc001whc.2	+	7	1353	c.1119G>C	c.(1117-1119)GAG>GAC	p.E373D		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	373	Hemopexin-like 2.|Extracellular (Potential).					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		CTGCCTACGAGAGGAAGGATG	0.537													15	170					0	0	0	0	C	23313687	C	C	23313687	3	2	253	1	0	0	0	0	1	0	0	0	9706	933	33	2	1145	2	MMP14	14	23313687	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08		23313687	84035853	65	46370											
HECTD1	25831	broad.mit.edu	37	chr14	31619322	31619322	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taattccaaggctgctgcatCactccaaatatataagcagt	14	11	6	10	0	1	0	1	0	0	0	3	0	3	0	2	1	3	4	2	1	6	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr14:31619322C>T	uc001wrc.1	-	13	2527	c.2038G>A	c.(2038-2040)GAT>AAT	p.D680N	HECTD1_uc001wrd.1_Missense_Mutation_p.D195N	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	680					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GCTGCTGCATCACTCCAAATA	0.418													19	147					0	0	0	0	T	31619322	T	T	31619322	3	4	253	1	0	0	0	0	1	0	0	0	7078	826	29	2	5918	2	HECTD1	14	31619322	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	8305635	31619322	75730218	66	46371											
BAZ1A	11177	broad.mit.edu	37	chr14	35343736	35343736	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgttggtgactttacagtaGaaaacttcctcgtcgggccg	8	12	11	10	4	0	2	0	1	0	1	4	2	1	2	2	2	2	2	2	2	4	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr14:35343736G>C	uc001wsk.2	-	2	643	c.75C>G	c.(73-75)TTC>TTG	p.F25L	BAZ1A_uc001wsl.2_Missense_Mutation_p.F25L|BAZ1A_uc001wsm.1_Missense_Mutation_p.F25L	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	25	WAC.|Required for association with the CHRAC1/POLE3 complex.|Required for interaction with NCOR1.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CTTTACAGTAGAAAACTTCCT	0.667													4	58					0	0	0	0	C	35343736	C	C	35343736	3	2	253	1	0	0	0	0	1	0	0	0	1331	933	33	2	4699	2	BAZ1A	14	35343736	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	3724414	35343736	72005804	67	46372											
MDGA2	161357	broad.mit.edu	37	chr14	47530684	47530684	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agctcctcagaaggaacagcTtctacttggcaagatatttt	12	12	8	9	0	2	2	1	0	1	2	3	3	3	3	1	2	4	3	1	2	5	6			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr14:47530684T>A	uc001wwj.3	-	7	1282	c.1086A>T	c.(1084-1086)GAA>GAT	p.E362D	MDGA2_uc001wwi.3_Missense_Mutation_p.E133D|MDGA2_uc010ani.2_Translation_Start_Site	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	362	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						AAGGAACAGCTTCTACTTGGC	0.403													40	64					0	0	0	0	A	47530684	A	A	47530684	3	1	253	1	0	0	0	0	1	0	0	0	9460	1606	56	5	1828	5	MDGA2	14	47530684	Missense_Mutation	SNP	T	TCGA-CV-7415-01A-11D-2078-08	12186948	47530684	59818856	68	46373											
DUOX1	53905	broad.mit.edu	37	chr15	45437213	45437213	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggagcaggagctgatgagaGcagctgtgacacgggagcag	11	4	19	7	1	0	3	0	3	0	1	0	7	0	6	0	3	5	5	0	3	0	0			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr15:45437213G>T	uc001zus.1	+	19	2603	c.2257G>T	c.(2257-2259)GCA>TCA	p.A753S	DUOX1_uc001zut.1_Missense_Mutation_p.A753S|DUOX1_uc010bee.1_Missense_Mutation_p.A133S|DUOX1_uc001zuu.2_5'Flank	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	753	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		GCTGATGAGAGCAGCTGTGAC	0.592													7	61					5.18039e-06	1.14926e-05	1	0	T	45437213	T	T	45437213	3	4	253	1	0	0	0	0	1	0	0	0	4822	971	34	4	2323	4	DUOX1	15	45437213	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08		45437213	57094179	69	46374											
BLM	641	broad.mit.edu	37	chr15	91312807	91312807	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gactcagctgaagattctcaGacctcaggtgtaagttgttg	10	12	11	8	0	3	3	3	1	1	2	4	4	3	3	1	1	1	4	1	1	2	4			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr15:91312807G>C	uc002bpr.2	+	12	2643	c.2546G>C	c.(2545-2547)AGA>ACA	p.R849T	BLM_uc010uqh.1_Missense_Mutation_p.R849T|BLM_uc010uqi.1_Missense_Mutation_p.R474T|BLM_uc010bnx.2_Missense_Mutation_p.R849T|BLM_uc002bps.1_Missense_Mutation_p.R411T	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	849	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			AAGATTCTCAGACCTCAGGTG	0.517			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				4	27					0	0	0	0	C	91312807	C	C	91312807	3	2	253	1	0	0	0	0	1	0	0	0	1448	942	33	2	2588	2	BLM	15	91312807	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	45875594	91312807	11218585	70	46375											
MSLN	10232	broad.mit.edu	37	chr16	816458	816458	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaccctgaaggctttgcttGaagtcaacaaagggcacgaa	14	7	11	9	1	1	3	1	2	0	1	1	4	1	3	1	2	2	3	1	2	5	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr16:816458G>C	uc002cjw.1	+	12	1249	c.1198G>C	c.(1198-1200)GAA>CAA	p.E400Q	MSLN_uc002cjt.1_Missense_Mutation_p.E400Q|MSLN_uc002cju.1_Missense_Mutation_p.E400Q|MSLN_uc010brd.1_Missense_Mutation_p.E399Q|MSLN_uc002cjv.1_Missense_Mutation_p.E400Q|MSLN_uc002cjx.1_Missense_Mutation_p.E400Q|MSLN_uc002cjy.1_Missense_Mutation_p.E65Q	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	400					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				GGCTTTGCTTGAAGTCAACAA	0.572													10	62					0	0	0	0	C	816458	C	C	816458	3	2	253	1	0	0	0	0	1	0	0	0	9934	1291	45	2	1240	2	MSLN	16	816458	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08		816458	89538295	71	46376											
SETD6	79918	broad.mit.edu	37	chr16	58550236	58550236	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagctgggccgcttggagcaCccgatgttctggtgagagcc	6	8	16	11	2	1	1	0	1	1	1	1	5	1	2	3	3	3	4	3	3	0	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr16:58550236C>T	uc002ens.2	+	3	524	c.465C>T	c.(463-465)CAC>CAT	p.H155H	SETD6_uc010cdl.2_Silent_p.H155H|SETD6_uc002enr.2_Silent_p.H131H|SETD6_uc010cdm.2_RNA|SETD6_uc010vij.1_Silent_p.H79H	NM_001160305	NP_001153777	Q8TBK2	SETD6_HUMAN	SET domain containing 6 isoform a	155	SET.				negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			ovary(1)	1						GCTTGGAGCACCCGATGTTCT	0.672													5	34					0	0	0	0	T	58550236	T	T	58550236	2	4	253	1	0	0	0	0	0	0	0	1	14200	506	18	4		4	SETD6	16	58550236	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08	57733778	58550236	31804517	72	46377											
FTSJD1	55783	broad.mit.edu	37	chr16	71318560	71318560	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actacaaccaatactagattTttttactagccaattatttc	14	16	2	9	0	0	1	0	0	0	1	1	1	0	1	2	0	5	0	2	0	9	10			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr16:71318560T>A	uc010cga.2	-	3	1670	c.1264A>T	c.(1264-1266)AAA>TAA	p.K422*	FTSJD1_uc002ezy.3_Nonsense_Mutation_p.K422*|FTSJD1_uc002ezz.3_Nonsense_Mutation_p.K422*	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	422						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						ATACTAGATTTTTTTACTAGC	0.299													7	62					0	0	0	0	A	71318560	A	A	71318560	4	1	253	1	0	0	0	0	0	1	0	0	6124	1850	64	5	1052	5	FTSJD1	16	71318560	Nonsense_Mutation	SNP	T	TCGA-CV-7415-01A-11D-2078-08	12768324	71318560	19036193	73	46378											
DHODH	1723	broad.mit.edu	37	chr16	72046004	72046004	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggaggacttctcttcgcctCctacctgatggccacgggag	7	9	12	13	2	1	1	0	1	1	0	4	4	2	4	4	4	1	0	4	4	1	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr16:72046004C>A	uc002fbp.2	+	2	98	c.77C>A	c.(76-78)TCC>TAC	p.S26Y	DHODH_uc010cgk.2_RNA	NM_001361	NP_001352	Q02127	PYRD_HUMAN	dihydroorotate dehydrogenase precursor	26	Helical; (By similarity).				'de novo' pyrimidine base biosynthetic process|pyrimidine nucleoside biosynthetic process|UMP biosynthetic process	integral to membrane|mitochondrial inner membrane	dihydroorotate oxidase activity				0		Ovarian(137;0.125)			Atovaquone(DB01117)|Leflunomide(DB01097)	CTCTTCGCCTCCTACCTGATG	0.602													16	105					1.3612e-06	3.0454e-06	1	0	A	72046004	A	A	72046004	3	1	253	1	0	0	0	0	1	0	0	0	4506	855	30	2	83	2	DHODH	16	72046004	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	727444	72046004	18308749	74	46379											
CDT1	81620	broad.mit.edu	37	chr16	88873832	88873832	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgaacgcaagcctgcgctCagcatggaggtggcctgtgc	7	7	14	13	3	1	0	1	0	0	0	2	2	2	1	3	3	5	3	3	3	2	0			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr16:88873832C>G	uc002flu.2	+	9	1473	c.1419C>G	c.(1417-1419)CTC>CTG	p.L473L		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	473					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		AGCCTGCGCTCAGCATGGAGG	0.657													5	47					0	0	0	0	G	88873832	G	G	88873832	2	3	253	1	0	0	0	0	0	0	0	1	3195	813	29	2		2	CDT1	16	88873832	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08	16827828	88873832	1480921	75	46380											
ALOX12	239	broad.mit.edu	37	chr17	6909233	6909233	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccgtcgggcggcagctcaGctgacctactgctccctctg	4	9	11	17	3	2	1	1	1	1	0	5	1	4	1	3	2	4	4	3	2	1	1	rs114312186	byFrequency	TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:6909233G>A	uc002gdx.3	+	10	1358	c.1305G>A	c.(1303-1305)CAG>CAA	p.Q435Q	uc002gdy.1_Intron	NM_000697	NP_000688	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	435	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			central_nervous_system(1)	1						CGGCAGCTCAGCTGACCTACT	0.632													3	27					0	0	0	0	A	6909233	A	A	6909233	2	1	253	1	0	0	0	0	0	0	0	1	536	962	34	4		4	ALOX12	17	6909233	Silent	SNP	G	TCGA-CV-7415-01A-11D-2078-08		6909233	74285977	76	46381											
TP53	7157	broad.mit.edu	37	chr17	7578532	7578532	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttggccagttggcaaaacAtcttgttgagggcaggggag	9	10	15	7	0	2	1	0	1	2	0	2	2	2	2	1	5	1	4	1	5	2	4	rs28934873		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:7578532A>T	uc002gim.2	-	5	592	c.398T>A	c.(397-399)ATG>AAG	p.M133K	TP53_uc002gig.1_Missense_Mutation_p.M133K|TP53_uc002gih.2_Missense_Mutation_p.M133K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.M1K|TP53_uc010cng.1_Missense_Mutation_p.M1K|TP53_uc002gii.1_Missense_Mutation_p.M1K|TP53_uc010cnh.1_Missense_Mutation_p.M133K|TP53_uc010cni.1_Missense_Mutation_p.M133K|TP53_uc002gij.2_Missense_Mutation_p.M133K|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.M40K|TP53_uc002gio.2_Missense_Mutation_p.M1K|TP53_uc010vug.1_Missense_Mutation_p.M94K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	133	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		KM -> NL (in a sporadic cancer; somatic mutation).|M -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).|M -> L (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> I (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M133K(12)|p.0?(7)|p.M133R(5)|p.M133fs*37(3)|p.M133I(3)|p.M133L(2)|p.N131fs*27(2)|p.M133T(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.Y126fs*11(1)|p.M133V(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.L130_M133delLNKM(1)|p.M133fs*16(1)|p.M133fs*13(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGCAAAACATCTTGTTGAG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	12					0	0	0	0	T	7578532	T	T	7578532	3	4	253	1	0	0	0	0	1	0	0	0	16448	217	8	5	900	5	TP53	17	7578532	Missense_Mutation	SNP	A	TCGA-CV-7415-01A-11D-2078-08	669299	7578532	73616678	77	46382											
STX8	9482	broad.mit.edu	37	chr17	9448488	9448488	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgtaaataaaaacatcctaCctgattagatctggttcggc	13	12	7	9	1	1	2	0	1	1	1	3	2	2	2	2	2	2	2	2	2	7	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:9448488C>T	uc002glx.2	-	4	473	c.323_splice	c.e4+1	p.R108_splice		NM_004853	NP_004844	Q9UNK0	STX8_HUMAN	syntaxin 8						transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1						AAACATCCTACCTGATTAGAT	0.418													5	36					0	0	0	0	T	9448488	T	T	9448488	5	4	253	1	0	0	0	0	0	0	1	0	15417	521	18	4	406	4	STX8	17	9448488	Splice_Site	SNP	C	TCGA-CV-7415-01A-11D-2078-08	1869956	9448488	71746722	78	46383											
DNAH9	1770	broad.mit.edu	37	chr17	11511572	11511572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttatacttgagcaagtgaagGgaaaaactttgctgcctctt	12	13	9	7	0	1	2	0	2	1	0	1	3	1	3	1	1	5	2	1	1	6	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:11511572G>A	uc002gne.2	+	2	612	c.544G>A	c.(544-546)GGA>AGA	p.G182R	DNAH9_uc002gnd.1_Missense_Mutation_p.G182R	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	182	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCAAGTGAAGGGAAAAACTTT	0.512													10	118					0	0	0	0	A	11511572	A	A	11511572	3	1	253	1	0	0	0	0	1	0	0	0	4630	1233	43	4	550	4	DNAH9	17	11511572	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	2063084	11511572	69683638	79	46384											
CNP	1267	broad.mit.edu	37	chr17	40125676	40125676	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgcgcccacatcaccctcGgctgtgcagctgacgtagag	7	6	12	16	4	1	2	1	1	0	1	2	2	1	2	3	1	2	4	3	1	1	1			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:40125676G>A	uc002hyl.1	+	4	1144	c.1000G>A	c.(1000-1002)GGC>AGC	p.G334S	CNP_uc010wfz.1_Missense_Mutation_p.G211S|CNP_uc002hym.1_Missense_Mutation_p.G314S|CNP_uc010wga.1_Missense_Mutation_p.G99S|CNP_uc002hyn.1_Missense_Mutation_p.G99S	NM_033133	NP_149124	P09543	CN37_HUMAN	2',3'-cyclic nucleotide 3' phosphodiesterase	334					cell killing|cyclic nucleotide catabolic process|RNA metabolic process|synaptic transmission	extracellular space|melanosome	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|ATP binding|protein binding				0		all_cancers(22;2.38e-06)|all_epithelial(22;6.79e-05)|Breast(137;0.000143)		UCEC - Uterine corpus endometrioid carcinoma (308;0.171)		CATCACCCTCGGCTGTGCAGC	0.647													7	38					0	0	0	0	A	40125676	A	A	40125676	3	1	253	1	0	0	0	0	1	0	0	0	3641	1116	39	1	1014	1	CNP	17	40125676	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	28614104	40125676	41069534	80	46385											
NMT1	4836	broad.mit.edu	37	chr17	43175850	43175850	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagatcaccaggcgggttCacctggagggcatcttccaa	10	7	13	11	1	3	1	2	0	1	1	4	4	4	2	3	4	0	2	3	4	1	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr17:43175850C>T	uc002ihz.2	+	7	832	c.814C>T	c.(814-816)CAC>TAC	p.H272Y	NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	272					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				CAGGCGGGTTCACCTGGAGGG	0.527													11	100					0	0	0	0	T	43175850	T	T	43175850	3	4	253	1	0	0	0	0	1	0	0	0	10557	826	29	2	840	2	NMT1	17	43175850	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	3050174	43175850	38019360	81	46386											
MYO5B	4645	broad.mit.edu	37	chr18	47373592	47373592	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctggaaatccttctctttCcgctggaccgtgacctgcct	5	12	8	16	2	1	1	0	1	1	0	4	3	3	3	6	2	1	1	6	2	1	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr18:47373592C>T	uc002leb.2	-	33	4671	c.4383G>A	c.(4381-4383)CGG>CGA	p.R1461R	MYO5B_uc002ldz.2_Silent_p.R31R|MYO5B_uc002lea.2_Silent_p.R576R	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1461	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CCTTCTCTTTCCGCTGGACCG	0.572													8	26					0	0	0	0	T	47373592	T	T	47373592	2	4	253	1	0	0	0	0	0	0	0	1	10132	842	30	2		2	MYO5B	18	47373592	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08		47373592	30703656	82	46387											
MUC16	94025	broad.mit.edu	37	chr19	9048921	9048921	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccattgaaggtgtggtctCtggttcaccaggagaaagag	10	9	15	7	0	2	3	1	1	1	2	3	4	2	3	2	5	0	1	2	5	2	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:9048921C>T	uc002mkp.2	-	5	32914	c.32710G>A	c.(32710-32712)GAG>AAG	p.E10904K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10906	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGTGGTCTCTGGTTCACCA	0.502													14	65					0	0	0	0	T	9048921	T	T	9048921	3	4	253	1	0	0	0	0	1	0	0	0	10026	922	32	2	11133	2	MUC16	19	9048921	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08		9048921	50080062	83	46388											
CHERP	10523	broad.mit.edu	37	chr19	16629998	16629998	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actcgtccctggccttcatgCgggcgatgaaggagtagctc	7	9	13	12	3	1	1	1	1	0	0	4	3	2	2	2	3	2	2	2	3	2	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:16629998C>G	uc002nei.1	-	17	2797	c.2723G>C	c.(2722-2724)CGC>CCC	p.R908P	MED26_uc002nee.2_RNA|C19orf44_uc002neh.1_Intron|C19orf44_uc010eai.1_Intron|CHERP_uc010xpg.1_Missense_Mutation_p.R447P	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	908					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GGCCTTCATGCGGGCGATGAA	0.637													3	13					0	0	0	0	G	16629998	G	G	16629998	3	3	253	1	0	0	0	0	1	0	0	0	3351	768	27	3	31	3	CHERP	19	16629998	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	7581077	16629998	42498985	84	46389											
SPTBN4	57731	broad.mit.edu	37	chr19	40993612	40993612	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctctcctccagatgagcggGaagccgtgcagaagaaaacc	12	5	11	13	2	1	4	0	1	1	3	3	5	2	5	5	1	4	1	5	1	4	0			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:40993612G>A	uc002ony.2	+	3	264	c.178G>A	c.(178-180)GAA>AAA	p.E60K	SPTBN4_uc002onx.2_Missense_Mutation_p.E60K|SPTBN4_uc002onz.2_Missense_Mutation_p.E60K	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	60	Actin-binding.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGATGAGCGGGAAGCCGTGCA	0.647													8	103					0	0	0	0	A	40993612	A	A	40993612	3	1	253	1	0	0	0	0	1	0	0	0	15187	1175	41	2	184	2	SPTBN4	19	40993612	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	24363614	40993612	18135371	85	46390											
PSG6	5675	broad.mit.edu	37	chr19	43414874	43414874	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacagctgcaacctgtgagtCatagggaggttctgaccatt	10	10	12	9	0	2	2	1	2	1	0	2	4	2	3	2	2	3	3	2	2	2	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:43414874C>T	uc002ovj.1	-	3	616	c.564G>A	c.(562-564)ATG>ATA	p.M188I	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Missense_Mutation_p.M195I|PSG6_uc002ovi.2_Missense_Mutation_p.M189I|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_5'UTR|PSG6_uc002ovf.1_Missense_Mutation_p.M188I|PSG6_uc002ovg.1_Missense_Mutation_p.M188I	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	188	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				ACCTGTGAGTCATAGGGAGGT	0.493													86	145					0	0	0	0	T	43414874	T	T	43414874	3	4	253	1	0	0	0	0	1	0	0	0	12721	826	29	2	798	2	PSG6	19	43414874	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	2421262	43414874	15714109	86	46391											
FTL	2512	broad.mit.edu	37	chr19	49468783	49468783	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatgagctcccagattcgtCagaattattccaccgacgtg	10	10	8	13	3	1	3	1	1	0	2	4	4	3	3	4	0	1	1	4	0	2	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:49468783C>T	uc002plo.2	+	1	218	c.19C>T	c.(19-21)CAG>TAG	p.Q7*	FTL_uc002pln.1_Nonsense_Mutation_p.Q7*	NM_000146	NP_000137	P02792	FRIL_HUMAN	ferritin, light polypeptide	7	Ferritin-like diiron.				cell death|cellular iron ion homeostasis|cellular membrane organization|iron ion transport|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|identical protein binding|oxidoreductase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000152)|all cancers(93;0.000435)|GBM - Glioblastoma multiforme(486;0.0171)|Epithelial(262;0.0267)	Iron Dextran(DB00893)	CCAGATTCGTCAGAATTATTC	0.567													69	52					0	0	0	0	T	49468783	T	T	49468783	4	4	253	1	0	0	0	0	0	1	0	0	6118	827	29	2	21	2	FTL	19	49468783	Nonsense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	6053909	49468783	9660200	87	46392											
LILRA5	353514	broad.mit.edu	37	chr19	54823872	54823872	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccactggctgcagctgtgcaGatggatgagaccatggtgcc	8	8	14	11	0	0	2	0	1	0	2	0	4	0	3	3	3	4	4	3	3	0	0			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:54823872G>C	uc002qfe.2	-	2	143	c.23C>G	c.(22-24)TCT>TGT	p.S8C	LILRA5_uc002qff.2_Missense_Mutation_p.S8C|LILRA5_uc010yev.1_Missense_Mutation_p.S8C|LILRA5_uc010yew.1_Missense_Mutation_p.S8C|LILRA5_uc002qfh.1_Missense_Mutation_p.S8C|LILRA5_uc002qfg.1_Missense_Mutation_p.S8C	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	8					innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGCTGTGCAGATGGATGAGA	0.597													5	40					0	0	0	0	C	54823872	C	C	54823872	3	2	253	1	0	0	0	0	1	0	0	0	8829	942	33	2	986	2	LILRA5	19	54823872	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	5355089	54823872	4305111	88	46393											
SLC27A5	10998	broad.mit.edu	37	chr19	59011756	59011756	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccctcacaggctccgccGcctccatgtcgaactgcacc	6	8	8	19	3	1	0	1	0	0	0	5	1	4	0	6	1	2	2	6	1	1	0			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr19:59011756G>T	uc002qtc.2	-	6	1528	c.1418C>A	c.(1417-1419)GCG>GAG	p.A473E	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	473	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		AGGCTCCGCCGCCTCCATGTC	0.627													10	48					1.05317e-09	2.43892e-09	1	0	T	59011756	T	T	59011756	3	4	253	1	0	0	0	0	1	0	0	0	14593	1087	38	3	674	3	SLC27A5	19	59011756	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	4187884	59011756	117227	89	46394											
BTG3	10950	broad.mit.edu	37	chr21	18981460	18981460	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggcagcaatttcattcttCatttttttccctgcaaagat	10	16	5	10	1	3	1	2	0	1	1	4	1	4	1	1	1	2	3	1	1	2	6			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr21:18981460C>A	uc002ykk.2	-	2	263	c.3G>T	c.(1-3)ATG>ATT	p.M1I	BTG3_uc002ykl.2_Missense_Mutation_p.M1I	NM_006806	NP_006797	Q14201	BTG3_HUMAN	B-cell translocation gene 3 isoform b	1					negative regulation of cell proliferation|negative regulation of mitotic cell cycle	cytoplasm					0				Epithelial(23;0.000283)|all cancers(11;0.0012)|Lung(58;0.0191)|OV - Ovarian serous cystadenocarcinoma(11;0.0206)|COAD - Colon adenocarcinoma(22;0.0315)|LUSC - Lung squamous cell carcinoma(23;0.0703)|Colorectal(24;0.0971)		TTTCATTCTTCATTTTTTTCC	0.348													33	35					5.8336e-16	1.38745e-15	1	0	A	18981460	A	A	18981460	3	1	253	1	0	0	0	0	1	0	0	0	1560	826	29	2	907	2	BTG3	21	18981460	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08		18981460	29148435	90	46395											
RIPK4	54101	broad.mit.edu	37	chr21	43161792	43161803	+	In_Frame_Del	DEL	GTGTGCTAGACT	-	-																															gttcttctccaacagcagccGtgtgctagactcgtccccgt																								rs148559295		TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr21:43161792_43161803delGTGTGCTAGACT	uc002yzn.1	-	8	1598_1609	c.1550_1561delAGTCTAGCACAC	c.(1549-1563)GAGTCTAGCACACGG>GGG	p.517_521ESSTR>G		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	517_521						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						AACAGCAGCCGTGTGCTAGACTCGTCCCCGTT	0.632													---	---	---								-	43161803	-	-	43161792	7	5	253	1	0	1	0	1	0	0	0	0	13448	1144	40	0	797	0	RIPK4	21	43161792	In_Frame_Del	DEL	GTGTGCTAGACT	TCGA-CV-7415-01A-11D-2078-08	24180332	43161792	4968103	91	46396											
TRPM2	7226	broad.mit.edu	37	chr21	45833913	45833913	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctactctgcctctacctgctCttcaccaacatcctgctgct	6	13	4	18	0	4	0	1	0	3	0	5	0	5	0	4	0	7	3	4	0	3	3			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chr21:45833913C>G	uc002zet.1	+	21	3315	c.3102C>G	c.(3100-3102)CTC>CTG	p.L1034L	TRPM2_uc002zeu.1_Silent_p.L1034L|TRPM2_uc002zew.1_Silent_p.L1034L|TRPM2_uc010gpt.1_Silent_p.L1034L|TRPM2_uc002zex.1_Silent_p.L820L|TRPM2_uc002zey.1_Silent_p.L547L	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1034	Helical; (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TCTACCTGCTCTTCACCAACA	0.657													38	299					0	0	0	0	G	45833913	G	G	45833913	2	3	253	1	0	0	0	0	0	0	0	1	16653	900	32	2		2	TRPM2	21	45833913	Silent	SNP	C	TCGA-CV-7415-01A-11D-2078-08	2672121	45833913	2295982	92	46397											
FGD1	2245	broad.mit.edu	37	chrX	54497839	54497839	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtctgagcgaagccgctggGgaccttctggatgaggctct	6	9	16	10	2	3	2	0	2	3	0	3	5	3	4	2	5	2	2	2	5	1	1			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:54497839G>A	uc004dtg.2	-	2	1123	c.389C>T	c.(388-390)CCC>CTC	p.P130L	FGD1_uc011moi.1_5'Flank	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	130	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						AAGCCGCTGGGGACCTTCTGG	0.607													4	14					0	0	0	0	A	54497839	A	A	54497839	3	1	253	1	0	0	0	0	1	0	0	0	5864	1232	43	4	2564	4	FGD1	23	54497839	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08		54497839	100772721	93	46398											
GPR174	84636	broad.mit.edu	37	chrX	78426986	78426986	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctcagaaccagtgatgataCctctggcaataggaccaaat	14	8	8	11	0	2	3	1	2	1	1	2	4	2	4	4	2	2	1	4	2	5	2			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:78426986C>A	uc004edg.1	+	1	518	c.482C>A	c.(481-483)ACC>AAC	p.T161N		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	161	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						AGTGATGATACCTCTGGCAAT	0.478										HNSCC(63;0.18)			18	29					9.16793e-09	2.08649e-08	1	0	A	78426986	A	A	78426986	3	1	253	1	0	0	0	0	1	0	0	0	6710	507	18	4	484	4	GPR174	23	78426986	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	23929147	78426986	76843574	94	46399											
PABPC5	140886	broad.mit.edu	37	chrX	90690579	90690579	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcccagtgctcagagagatGgggagcggggagcctaatcc	9	6	15	11	1	1	2	1	0	0	2	3	5	3	4	3	4	3	1	3	4	1	1			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:90690579G>A	uc004efg.2	+	2	443	c.3G>A	c.(1-3)ATG>ATA	p.M1I	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	1						cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						TCAGAGAGATGGGGAGCGGGG	0.512													10	6					0	0	0	0	A	90690579	A	A	90690579	3	1	253	1	0	0	0	0	1	0	0	0	11421	1348	47	4	5	4	PABPC5	23	90690579	Missense_Mutation	SNP	G	TCGA-CV-7415-01A-11D-2078-08	12263593	90690579	64579981	95	46400											
THOC2	57187	broad.mit.edu	37	chrX	122767908	122767908	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgtaccacttctttcaataTaagcaggtcaaaactattca	14	14	4	9	0	4	0	3	0	1	0	4	0	4	0	1	1	3	2	1	1	7	8			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:122767908T>C	uc004etu.2	-	20	2064	c.2032A>G	c.(2032-2034)ATA>GTA	p.I678V	THOC2_uc011muh.1_Missense_Mutation_p.I603V	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	678					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TCTTTCAATATAAGCAGGTCA	0.323													11	49					0	0	0	0	C	122767908	C	C	122767908	3	2	253	1	0	0	0	0	1	0	0	0	15931	1406	49	5	2825	5	THOC2	23	122767908	Missense_Mutation	SNP	T	TCGA-CV-7415-01A-11D-2078-08	32077329	122767908	32502652	96	46401											
GPC3	2719	broad.mit.edu	37	chrX	132888182	132888182	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgtagttcttggcatggCgaacaacaatttcaaaggcc	11	11	11	8	1	2	0	1	0	1	0	2	1	2	0	1	4	2	3	1	4	5	4	rs148021273	byFrequency	TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:132888182C>T	uc004exe.1	-	3	549	c.359G>A	c.(358-360)CGC>CAC	p.R120H	GPC3_uc004exd.1_5'UTR|GPC3_uc010nrn.1_Missense_Mutation_p.R120H|GPC3_uc011mvh.1_Missense_Mutation_p.R104H|GPC3_uc010nro.1_Missense_Mutation_p.R66H|GPC3_uc010nrp.1_5'UTR	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	120						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					CTTGGCATGGCGAACAACAAT	0.363			T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				7	72					0	0	0	0	T	132888182	T	T	132888182	3	4	253	1	0	0	0	0	1	0	0	0	6637	768	27	1	1480	1	GPC3	23	132888182	Missense_Mutation	SNP	C	TCGA-CV-7415-01A-11D-2078-08	10120274	132888182	22382378	97	46402											
PLAC1	10761	broad.mit.edu	37	chrX	133700419	133700419	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgcccttagaagagtagtgTatctcagtgctgtagataac	11	12	11	7	0	1	3	1	0	1	3	2	3	1	3	1	0	3	4	1	0	6	5			TCGA-CV-7415-01A-11D-2078-08	TCGA-CV-7415-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb1e4188-130c-4206-8671-d7ce3eb8ee74	bdfb06d0-6d6f-4acd-8520-fade65e20d95	g.chrX:133700419T>C	uc004exo.1	-	3	580	c.294A>G	c.(292-294)ATA>ATG	p.I98M	PLAC1_uc004exp.1_Missense_Mutation_p.I98M	NM_021796	NP_068568	Q9HBJ0	PLAC1_HUMAN	placenta-specific 1 precursor	98					placenta development	extracellular region				pancreas(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AAGAGTAGTGTATCTCAGTGC	0.522													80	22					0	0	0	0	C	133700419	C	C	133700419	3	2	253	1	0	0	0	0	1	0	0	0	12067	1628	57	5	348	5	PLAC1	23	133700419	Missense_Mutation	SNP	T	TCGA-CV-7415-01A-11D-2078-08	812237	133700419	21570141	98	46403											
CASZ1	54897	broad.mit.edu	37	chr1	10699678	10699678	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctgtttgccgtggtgcttgCgatgcgccgtgaccttggtg	2	13	15	11	4	0	1	0	1	0	0	0	2	0	1	4	2	4	2	4	2	0	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:10699678C>T	uc001aro.2	-	21	4921	c.4601G>A	c.(4600-4602)CGC>CAC	p.R1534H		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1534	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GTGGTGCTTGCGATGCGCCGT	0.662													5	7					0	0	0	0	T	10699678	T	T	10699678	3	4	254	1	0	0	0	0	1	0	0	0	2697	768	27	1	682	1	CASZ1	1	10699678	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08		10699678	238550943	1	46404											
PADI4	23569	broad.mit.edu	37	chr1	17682852	17682853	+	Missense_Mutation	DNP	GG	AT	AT																															cccagtgtttctgcctccagGgcttccggctgctcctggcc																										TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:17682852_17682853GG>AT	uc001baj.2	+	13	1484_1485	c.1456_1457GG>AT	c.(1456-1458)GGC>ATC	p.G486I		NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	486					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CTGCCTCCAGGGCTTCCGGCTG	0.609													3	21					0	0	0	0	AT	17682853	AT	AT	17682852	3	1	254	1	0	0	0	0	1	0	0	0	11434	1246	43	4	1506	4	PADI4	1	17682852	Missense_Mutation	DNP	GG	TCGA-CV-7416-01A-11D-2078-08	6983174	17682852	231567769	2	46405											
UBR4	23352	broad.mit.edu	37	chr1	19487581	19487581	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaaatcctgggttcactctGaaatgccgactccttcatgg	9	12	9	11	1	3	2	2	2	1	0	5	3	5	2	3	2	1	1	3	2	2	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:19487581G>A	uc001bbi.2	-	38	5240	c.5236C>T	c.(5236-5238)CAG>TAG	p.Q1746*	UBR4_uc001bbm.1_Nonsense_Mutation_p.Q957*	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1746					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGTTCACTCTGAAATGCCGAC	0.512													3	23					0	0	0	0	A	19487581	A	A	19487581	4	1	254	1	0	0	0	0	0	1	0	0	16972	1299	45	2	10591	2	UBR4	1	19487581	Nonsense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	1804729	19487581	229763040	3	46406											
GJA9	81025	broad.mit.edu	37	chr1	39341347	39341347	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggagctttatttagtttccTtttctccagctgacaaagct	8	17	7	9	0	1	1	0	1	1	0	3	2	2	2	2	1	3	4	2	1	3	7			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:39341347T>G	uc001cct.1	-	2	705	c.424A>C	c.(424-426)AGG>CGG	p.R142R	RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399	P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	142	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			TTTAGTTTCCTTTTCTCCAGC	0.433													26	51					0	0	0	0	G	39341347	G	G	39341347	2	3	254	1	0	0	0	0	0	0	0	1	6443	1608	56	5		5	GJA9	1	39341347	Silent	SNP	T	TCGA-CV-7416-01A-11D-2078-08	19853766	39341347	209909274	4	46407											
MSH4	4438	broad.mit.edu	37	chr1	76269464	76269464	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagaaaacacagttgcatCaaattttacttttggtgcaa	14	13	7	7	0	1	1	1	0	0	1	1	1	1	1	0	1	5	4	0	1	5	5			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:76269464C>T	uc001dhd.1	+	2	334	c.293C>T	c.(292-294)TCA>TTA	p.S98L		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	98					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						ACAGTTGCATCAAATTTTACT	0.328								MMR					5	39					0	0	0	0	T	76269464	T	T	76269464	3	4	254	1	0	0	0	0	1	0	0	0	9925	838	29	2	299	2	MSH4	1	76269464	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	36928117	76269464	172981157	5	46408											
IGSF8	93185	broad.mit.edu	37	chr1	160062266	160062266	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacagggcctcctccaggcCggactcccagctctgccaca	7	6	10	18	1	1	1	0	1	1	0	4	2	4	2	6	3	2	1	6	3	0	0			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:160062266C>T	uc001fva.2	-	5	1577	c.1532G>A	c.(1531-1533)CGG>CAG	p.R511Q	IGSF8_uc001fuz.2_Missense_Mutation_p.R511Q|IGSF8_uc009wtf.2_Missense_Mutation_p.R511Q	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	511	Ig-like C2-type 4.|Extracellular (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TCCTCCAGGCCGGACTCCCAG	0.662													5	19					0	0	0	0	T	160062266	T	T	160062266	3	4	254	1	0	0	0	0	1	0	0	0	7643	652	23	1	317	1	IGSF8	1	160062266	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	83792802	160062266	89188355	6	46409											
PFDN2	5202	broad.mit.edu	37	chr1	161071851	161071851	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgctcacctgctccttgttgTtctccaaagcgggcagcacc	6	11	9	15	1	2	0	1	0	1	0	4	0	3	0	4	1	4	6	4	1	1	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:161071851T>C	uc001fxu.2	-	3	325	c.275A>G	c.(274-276)AAC>AGC	p.N92S		NM_012394	NP_036526	Q9UHV9	PFD2_HUMAN	prefoldin subunit 2	92					'de novo' posttranslational protein folding	prefoldin complex	unfolded protein binding				0	all_cancers(52;1.84e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CTCCTTGTTGTTCTCCAAAGC	0.343													6	22					0	0	0	0	C	161071851	C	C	161071851	3	2	254	1	0	0	0	0	1	0	0	0	11811	1725	60	5	197	5	PFDN2	1	161071851	Missense_Mutation	SNP	T	TCGA-CV-7416-01A-11D-2078-08	1009585	161071851	88178770	7	46410											
SOX13	9580	broad.mit.edu	37	chr1	204085788	204085788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcagcagcagatggagcttgCccggcagcagcaggagcagg	10	3	17	11	1	0	1	0	0	0	1	0	3	0	3	1	4	7	8	1	4	0	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr1:204085788C>T	uc001ham.2	+	5	1167	c.572C>T	c.(571-573)GCC>GTC	p.A191V	SOX13_uc001hal.2_Missense_Mutation_p.A191V|SOX13_uc010pqp.1_Missense_Mutation_p.A191V|SOX13_uc010pqq.1_Missense_Mutation_p.A58V	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	191	Gln-rich.				anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			ATGGAGCTTGCCCGGCAGCAG	0.587													3	38					0	0	0	0	T	204085788	T	T	204085788	3	4	254	1	0	0	0	0	1	0	0	0	15008	739	26	4	586	4	SOX13	1	204085788	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	43013937	204085788	45164833	8	46411											
KHK	3795	broad.mit.edu	37	chr2	27317367	27317367	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcctggatgacctccgcCgctattctgtggacctacgc	5	12	10	14	3	1	1	0	1	1	0	3	3	3	3	5	2	1	1	5	2	2	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:27317367C>T	uc002ril.2	+	3	749	c.232C>T	c.(232-234)CGC>TGC	p.R78C	KHK_uc002rim.2_Intron|KHK_uc002rin.2_Missense_Mutation_p.R79C|KHK_uc002rio.2_Intron	NM_000221	NP_000212	P50053	KHK_HUMAN	ketohexokinase isoform a	78					fructose catabolic process	cytosol	ATP binding|ketohexokinase activity|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACCTCCGCCGCTATTCTGT	0.597													20	51					0	0	0	0	T	27317367	T	T	27317367	3	4	254	1	0	0	0	0	1	0	0	0	8188	652	23	1	242	1	KHK	2	27317367	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08		27317367	215882006	9	46412											
FBXO11	80204	broad.mit.edu	37	chr2	48066041	48066041	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcactgaagcgtttacataCacaagctgctctacaaagat	14	11	6	10	1	2	2	1	1	1	1	2	2	2	2	0	0	6	3	0	0	6	5			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:48066041C>T	uc010fbl.2	-	4	406	c.292G>A	c.(292-294)GTA>ATA	p.V98I	FBXO11_uc002rwe.2_Missense_Mutation_p.V98I|FBXO11_uc002rwf.2_Missense_Mutation_p.V98I|FBXO11_uc002rwg.1_Missense_Mutation_p.V98I	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	182	F-box.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CGTTTACATACACAAGCTGCT	0.378													3	40					0	0	0	0	T	48066041	T	T	48066041	3	4	254	1	0	0	0	0	1	0	0	0	5759	478	17	4	2409	4	FBXO11	2	48066041	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	20748674	48066041	195133332	10	46413											
POLR1A	25885	broad.mit.edu	37	chr2	86279995	86279995	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgaagaggcgggccaggcaGgttagaaccttgccgctggt	8	7	17	9	2	0	3	0	1	0	2	0	3	0	3	3	5	2	3	3	5	3	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:86279995G>A	uc002sqs.2	-	16	2716	c.2337C>T	c.(2335-2337)ACC>ACT	p.T779T	POLR1A_uc010ytb.1_Silent_p.T145T	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	779					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GGGCCAGGCAGGTTAGAACCT	0.642													11	19					0	0	0	0	A	86279995	A	A	86279995	2	1	254	1	0	0	0	0	0	0	0	1	12264	987	35	4		4	POLR1A	2	86279995	Silent	SNP	G	TCGA-CV-7416-01A-11D-2078-08	38213954	86279995	156919378	11	46414											
TBR1	10716	broad.mit.edu	37	chr2	162273105	162273105	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaccagggggatgacgaatCagtcagatacagacaatttt	14	10	10	7	1	2	3	2	1	0	2	2	5	2	4	1	2	2	0	1	2	4	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:162273105C>T	uc002ubw.1	+	1	486	c.184C>T	c.(184-186)CAG>TAG	p.Q62*	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	62						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GATGACGAATCAGTCAGATAC	0.493													13	38					0	0	0	0	T	162273105	T	T	162273105	4	4	254	1	0	0	0	0	0	1	0	0	15713	827	29	2	186	2	TBR1	2	162273105	Nonsense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	75993110	162273105	80926268	12	46415											
WIPF1	7456	broad.mit.edu	37	chr2	175431842	175431842	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctgggataacttttggtcGtttgtacatatggctctgga	7	16	12	6	1	1	0	0	0	1	0	2	2	1	2	0	4	3	4	0	4	3	6			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:175431842G>A	uc002uiy.2	-	8	1744	c.1412C>T	c.(1411-1413)ACG>ATG	p.T471M	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.T471M|WIPF1_uc010fqt.1_Missense_Mutation_p.T471M|WIPF1_uc002uiz.2_Missense_Mutation_p.T471M|WIPF1_uc002ujb.1_Missense_Mutation_p.T471M	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	471					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						ACTTTTGGTCGTTTGTACATA	0.458													14	33					0	0	0	0	A	175431842	A	A	175431842	3	1	254	1	0	0	0	0	1	0	0	0	17435	1145	40	1	107	1	WIPF1	2	175431842	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	13158737	175431842	67767531	13	46416											
C2orf67	151050	broad.mit.edu	37	chr2	211018847	211018847	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtctttggttatatttgaatCcagaataatttgtacatctt	11	19	6	5	0	2	2	0	1	2	1	3	2	3	2	1	1	1	2	1	1	6	8			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:211018847C>A	uc002vds.2	-	2	668	c.460G>T	c.(460-462)GAT>TAT	p.D154Y	C2orf67_uc002vdt.2_Missense_Mutation_p.D154Y|C2orf67_uc002vdw.2_Missense_Mutation_p.D154Y|C2orf67_uc002vdy.1_Missense_Mutation_p.D154Y|C2orf67_uc002vdv.2_Missense_Mutation_p.D154Y|C2orf67_uc002vdx.1_Missense_Mutation_p.D154Y	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	154										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		ATATTTGAATCCAGAATAATT	0.348													8	23					0.000274275	0.000291889	1	0	A	211018847	A	A	211018847	3	1	254	1	0	0	0	0	1	0	0	0	2196	855	30	2	2559	2	C2orf67	2	211018847	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	35587005	211018847	32180526	14	46417											
CXCR2	3579	broad.mit.edu	37	chr2	219000421	219000421	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccgggctctggatgccacCgagattctgggcatccttca	7	9	12	13	2	3	1	1	0	2	1	4	4	4	2	4	3	1	2	4	3	0	2	rs13306439		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:219000421C>T	uc002vgz.1	+	4	1122	c.897C>T	c.(895-897)ACC>ACT	p.T299T	CXCR2_uc002vha.1_Silent_p.T299T|CXCR2_uc002vhb.1_Silent_p.T299T	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	299	Helical; Name=7; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						TGGATGCCACCGAGATTCTGG	0.567													9	60					0	0	0	0	T	219000421	T	T	219000421	2	4	254	1	0	0	0	0	0	0	0	1	4108	639	23	1		1	CXCR2	2	219000421	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08	7981574	219000421	24198952	15	46418											
WDFY1	57590	broad.mit.edu	37	chr2	224743419	224743419	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaacccagtcgccagactgCagcccaccacaggtgtcatg	12	5	9	15	1	1	1	1	0	0	1	2	1	1	1	4	1	3	1	4	1	2	0			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:224743419C>T	uc002vnq.2	-	12	1253	c.1202G>A	c.(1201-1203)TGC>TAC	p.C401Y		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	401	WD 7.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		CGCCAGACTGCAGCCCACCAC	0.542													4	15					0	0	0	0	T	224743419	T	T	224743419	3	4	254	1	0	0	0	0	1	0	0	0	17336	710	25	4	34	4	WDFY1	2	224743419	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	5742998	224743419	18455954	16	46419											
COL4A4	1286	broad.mit.edu	37	chr2	227945173	227945173	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acatactggaggtcctggatCccctttttctccagcatgtc	7	13	8	13	0	1	0	0	0	1	0	5	2	3	2	4	3	2	1	4	3	1	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr2:227945173C>G	uc010zlt.1	-	24	2443	c.1789G>C	c.(1789-1791)GAT>CAT	p.D597H		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	597	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GGTCCTGGATCCCCTTTTTCT	0.463													15	54					0	0	0	0	G	227945173	G	G	227945173	3	3	254	1	0	0	0	0	1	0	0	0	3708	855	30	2	3383	2	COL4A4	2	227945173	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	3201754	227945173	15254200	17	46420											
DCLK3	85443	broad.mit.edu	37	chr3	36779850	36779850	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttgctactgggttctggctCccatttccccctcccccact	3	13	6	19	0	1	0	0	0	1	0	4	0	4	0	5	2	2	3	5	2	1	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:36779850C>T	uc003cgi.2	-	2	792	c.301G>A	c.(301-303)GAG>AAG	p.E101K		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	101						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						GGTTCTGGCTCCCATTTCCCC	0.592													46	85					0	0	0	0	T	36779850	T	T	36779850	3	4	254	1	0	0	0	0	1	0	0	0	4310	864	30	2	1661	2	DCLK3	3	36779850	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08		36779850	161242580	18	46421											
DCLK3	85443	broad.mit.edu	37	chr3	36779895	36779895	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgggtcctcgctctgtcatCtagtgaaagctcctcgggga	6	11	12	12	2	3	1	1	1	2	0	7	2	5	2	2	3	1	2	2	3	2	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:36779895C>G	uc003cgi.2	-	2	747	c.256G>C	c.(256-258)GAT>CAT	p.D86H		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	86						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						GCTCTGTCATCTAGTGAAAGC	0.622													51	100					0	0	0	0	G	36779895	G	G	36779895	3	3	254	1	0	0	0	0	1	0	0	0	4310	913	32	2	1706	2	DCLK3	3	36779895	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	45	36779895	161242535	19	46422											
PLCD1	5333	broad.mit.edu	37	chr3	38050888	38050888	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttgcagtaaatgaccatgTcagagagctcctgtgctagc	10	11	10	10	0	2	2	1	1	1	1	3	3	3	2	2	0	4	4	2	0	3	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:38050888T>C	uc003chn.2	-	10	1605	c.1481A>G	c.(1480-1482)GAC>GGC	p.D494G	PLCD1_uc003chm.2_Missense_Mutation_p.D515G	NM_006225	NP_006216	P51178	PLCD1_HUMAN	phospholipase C, delta 1 isoform 2	494	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		AATGACCATGTCAGAGAGCTC	0.577													17	14					0	0	0	0	C	38050888	C	C	38050888	3	2	254	1	0	0	0	0	1	0	0	0	12086	1667	58	5	813	5	PLCD1	3	38050888	Missense_Mutation	SNP	T	TCGA-CV-7416-01A-11D-2078-08	1270993	38050888	159971542	20	46423											
CACNA2D2	9254	broad.mit.edu	37	chr3	50402370	50402370	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctctccggtatcgcggtctCtgcactagctcacactgctc	5	11	8	17	3	3	0	1	0	2	0	7	0	3	0	2	2	3	4	2	2	2	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:50402370C>T	uc003daq.2	-	38	3299	c.3261G>A	c.(3259-3261)CAG>CAA	p.Q1087Q	CACNA2D2_uc003dap.2_Silent_p.Q1080Q|CACNA2D2_uc003dao.2_Silent_p.Q160Q	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	1087	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	ATCGCGGTCTCTGCACTAGCT	0.453													8	30					0	0	0	0	T	50402370	T	T	50402370	2	4	254	1	0	0	0	0	0	0	0	1	2561	912	32	2		2	CACNA2D2	3	50402370	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08	12351482	50402370	147620060	21	46424											
MYH15	22989	broad.mit.edu	37	chr3	108117636	108117636	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcagccacagccacctgctCcttcagatcactgttcagtt	8	11	6	16	0	4	1	4	0	0	1	5	1	5	1	4	0	3	3	4	0	0	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:108117636C>A	uc003dxa.1	-	36	5098	c.5041G>T	c.(5041-5043)GAG>TAG	p.E1681*		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1681	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GCCACCTGCTCCTTCAGATCA	0.537													9	163					0.000673444	0.000710177	1	0	A	108117636	A	A	108117636	4	1	254	1	0	0	0	0	0	1	0	0	10087	864	30	2	827	2	MYH15	3	108117636	Nonsense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	57715266	108117636	89904794	22	46425											
SEMA5B	54437	broad.mit.edu	37	chr3	122647874	122647874	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgctttggcaggagcggCgcgtgtcctcactggaggcc	4	10	15	12	3	1	0	1	0	0	0	2	2	2	2	2	5	2	2	2	5	0	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr3:122647874C>T	uc003efz.1	-	6	810	c.506G>A	c.(505-507)CGC>CAC	p.R169H	SEMA5B_uc011bju.1_Missense_Mutation_p.R111H|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.R169H|SEMA5B_uc010hro.1_Missense_Mutation_p.R111H|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	169	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		GCAGGAGCGGCGCGTGTCCTC	0.617													8	30					0	0	0	0	T	122647874	T	T	122647874	3	4	254	1	0	0	0	0	1	0	0	0	14103	768	27	1	3021	1	SEMA5B	3	122647874	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	14530238	122647874	75374556	23	46426											
MTTP	4547	broad.mit.edu	37	chr4	100543978	100543978	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggtgtttgcccctcagccGgatagtacttccagcggatg	6	11	13	11	2	1	0	1	0	0	0	2	2	2	2	4	3	4	2	4	3	2	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr4:100543978G>A	uc003hvc.3	+	19	2914	c.2658G>A	c.(2656-2658)CCG>CCA	p.P886P	MTTP_uc011cej.1_Silent_p.P913P	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	886					lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	CCCCTCAGCCGGATAGTACTT	0.443													24	55					0	0	0	0	A	100543978	A	A	100543978	2	1	254	1	0	0	0	0	0	0	0	1	10017	1103	39	1		1	MTTP	4	100543978	Silent	SNP	G	TCGA-CV-7416-01A-11D-2078-08		100543978	90610298	24	46427											
NKD2	85409	broad.mit.edu	37	chr5	1032273	1032273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgttcttcctgcaggagctgCccaatggggaccccaaggag	8	7	13	13	1	1	0	0	0	1	0	2	3	2	3	4	4	3	3	4	4	2	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr5:1032273C>T	uc003jbt.1	+	4	153	c.148C>T	c.(148-150)CCC>TCC	p.P50S	NKD2_uc010itf.1_Missense_Mutation_p.P50S	NM_033120	NP_149111	Q969F2	NKD2_HUMAN	naked cuticle homolog 2	50	Targeting to the basolateral cell membrane.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding				0	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			GCAGGAGCTGCCCAATGGGGA	0.662													22	204					0	0	0	0	T	1032273	T	T	1032273	3	4	254	1	0	0	0	0	1	0	0	0	10496	739	26	4	162	4	NKD2	5	1032273	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08		1032273	179882987	25	46428											
RXFP3	51289	broad.mit.edu	37	chr5	33937016	33937016	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagctggggctggagttgccGgacggcgcgccgccaggaca	6	4	19	12	5	0	0	0	0	0	0	0	4	0	3	3	6	2	3	3	6	0	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr5:33937016G>A	uc003jic.1	+	1	528	c.171G>A	c.(169-171)CCG>CCA	p.P57P		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	57	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						TGGAGTTGCCGGACGGCGCGC	0.687													14	153					0	0	0	0	A	33937016	A	A	33937016	2	1	254	1	0	0	0	0	0	0	0	1	13826	1103	39	1		1	RXFP3	5	33937016	Silent	SNP	G	TCGA-CV-7416-01A-11D-2078-08	32904743	33937016	146978244	26	46429											
MARVELD2	153562	broad.mit.edu	37	chr5	68716051	68716051	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggcatgtccatgtattaccGgaccattcttctggactcta	8	14	8	11	1	3	0	0	0	3	0	4	2	4	2	3	3	1	2	3	3	3	5			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr5:68716051G>A	uc003jwq.2	+	2	898	c.839G>A	c.(838-840)CGG>CAG	p.R280Q	MARVELD2_uc010ixf.2_Missense_Mutation_p.R280Q|MARVELD2_uc003jwr.1_Missense_Mutation_p.R280Q|MARVELD2_uc003jws.1_Intron	NM_001038603	NP_001033692	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2 isoform 1	280	MARVEL.|Extracellular (Potential).				sensory perception of sound	integral to membrane|tight junction					0		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		ATGTATTACCGGACCATTCTT	0.433													15	55					0	0	0	0	A	68716051	A	A	68716051	3	1	254	1	0	0	0	0	1	0	0	0	9371	1116	39	1	841	1	MARVELD2	5	68716051	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	34779035	68716051	112199209	27	46430											
PCDHA4	56144	broad.mit.edu	37	chr5	140187182	140187182	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccggtgttcccagcaacacAaaagaacctgtccatcgcgg	11	6	10	14	3	0	1	0	0	0	1	3	1	2	1	4	2	3	2	4	2	4	1	rs144914662	byFrequency	TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr5:140187182A>C	uc003lhi.2	+	1	511	c.410A>C	c.(409-411)CAA>CCA	p.Q137P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.Q137P|PCDHA4_uc011daa.1_Missense_Mutation_p.Q137P	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	137	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGCAACACAAAAGAACCTG	0.572													4	82					0	0	0	0	C	140187182	C	C	140187182	3	2	254	1	0	0	0	0	1	0	0	0	11580	130	5	5	412	5	PCDHA4	5	140187182	Missense_Mutation	SNP	A	TCGA-CV-7416-01A-11D-2078-08	71471131	140187182	40728078	28	46431											
ZFAND3	60685	broad.mit.edu	37	chr6	38084407	38084407	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cacgactacttgagaatacgGaacggtccgaggaaaccagt	14	6	11	10	4	0	1	0	1	0	1	1	6	1	3	2	3	4	0	2	3	5	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr6:38084407G>C	uc003onx.2	+	5	836	c.421G>C	c.(421-423)GAA>CAA	p.E141Q		NM_021943	NP_068762	Q9H8U3	ZFAN3_HUMAN	zinc finger, AN1-type domain 3	141							DNA binding|zinc ion binding			ovary(1)	1						TGAGAATACGGAACGGTCCGA	0.498													14	33					0	0	0	0	C	38084407	C	C	38084407	3	2	254	1	0	0	0	0	1	0	0	0	17696	1175	41	2	439	2	ZFAND3	6	38084407	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08		38084407	133030660	29	46432											
SLC22A7	10864	broad.mit.edu	37	chr6	43267656	43267656	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agctggagtggctggatgtgGagcaccgcaccgtggctgga	7	7	18	9	2	0	0	0	0	0	0	0	4	0	4	2	6	2	5	2	6	0	0			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr6:43267656G>C	uc003out.2	+	5	778	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	SLC22A7_uc010jyl.1_Missense_Mutation_p.E228Q|SLC22A7_uc003ous.2_Missense_Mutation_p.E225Q	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	227						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GCTGGATGTGGAGCACCGCAC	0.607													17	42					0	0	0	0	C	43267656	C	C	43267656	3	2	254	1	0	0	0	0	1	0	0	0	14523	1175	41	2	693	2	SLC22A7	6	43267656	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	5183249	43267656	127847411	30	46433											
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26233291	26233291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcttcctcctccataacCggggctacctccaaaattgc	8	11	5	17	1	1	0	0	0	1	0	6	0	6	0	7	2	3	1	7	2	4	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr7:26233291C>T	uc003sxr.3	-	9	997	c.781G>A	c.(781-783)GGT>AGT	p.G261S	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.G249S	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	261	Gly-rich.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCTCCATAACCGGGGCTACCT	0.448			T	ETV1	prostate								20	55					0	0	0	0	T	26233291	T	T	26233291	3	4	254	1	0	0	0	0	1	0	0	0	7298	652	23	1	292	1	HNRNPA2B1	7	26233291	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08		26233291	132905372	31	46434											
AUTS2	26053	broad.mit.edu	37	chr7	70254942	70254942	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acgagcacaaggcgaaagagGgccacctgcccgagaaggac	14	1	14	12	3	0	2	0	0	0	2	0	6	0	3	3	3	2	1	3	3	3	0			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr7:70254942G>A	uc003tvw.3	+	19	3483	c.2740G>A	c.(2740-2742)GGC>AGC	p.G914S	AUTS2_uc003tvx.3_Missense_Mutation_p.G890S|AUTS2_uc011keg.1_Missense_Mutation_p.G366S	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	914										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GGCGAAAGAGGGCCACCTGCC	0.687													3	15					0	0	0	0	A	70254942	A	A	70254942	3	1	254	1	0	0	0	0	1	0	0	0	1227	1232	43	4	2959	4	AUTS2	7	70254942	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	44021651	70254942	88883721	32	46435											
FLNC	2318	broad.mit.edu	37	chr7	128497288	128497288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagtgtcctgagggccatGtggtcacttatactcccatg	7	11	13	10	0	1	1	1	1	0	0	3	2	3	2	3	3	1	0	3	3	2	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr7:128497288G>A	uc003vnz.3	+	46	7887	c.7678G>A	c.(7678-7680)GTG>ATG	p.V2560M	FLNC_uc003voa.3_Missense_Mutation_p.V2527M	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2560	Interaction with INPPL1.|Filamin 23.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TGAGGGCCATGTGGTCACTTA	0.607													16	71					0	0	0	0	A	128497288	A	A	128497288	3	1	254	1	0	0	0	0	1	0	0	0	5967	1377	48	4	7860	4	FLNC	7	128497288	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	58242346	128497288	30641375	33	46436											
SSPO	23145	broad.mit.edu	37	chr7	149509044	149509044	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cccttggagccagtgttcagCctcctgtggccctgcccggt	3	10	12	16	1	1	0	1	0	0	0	2	1	2	1	6	3	3	1	6	3	0	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr7:149509044C>G	uc010lpk.2	+	69	9590	c.9590C>G	c.(9589-9591)GCC>GGC	p.A3197G		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3197	TSP type-1 11.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGTGTTCAGCCTCCTGTGGC	0.697													3	53					0	0	0	0	G	149509044	G	G	149509044	3	3	254	1	0	0	0	0	1	0	0	0	15255	739	26	4	9854	4	SSPO	7	149509044	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	21011756	149509044	9629619	34	46437											
MLL3	58508	broad.mit.edu	37	chr7	151879181	151879181	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggtgtacagttttccactgGtgcagcagaatttcttctgg	8	14	11	8	0	2	1	0	0	2	1	3	1	3	1	1	3	3	4	1	3	2	5			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr7:151879181G>C	uc003wla.2	-	36	5983	c.5764C>G	c.(5764-5766)CCA>GCA	p.P1922A	MLL3_uc003wkz.2_Missense_Mutation_p.P983A	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1922	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTTTCCACTGGTGCAGCAGAA	0.463			N		medulloblastoma								17	56					0	0	0	0	C	151879181	C	C	151879181	3	2	254	1	0	0	0	0	1	0	0	0	9675	1261	44	4	9067	4	MLL3	7	151879181	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	2370137	151879181	7259482	35	46438											
PKHD1L1	93035	broad.mit.edu	37	chr8	110441662	110441662	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaacatgtacttggagacCtacttcgtacacccagtcaa	13	9	7	12	1	1	1	1	0	0	1	2	3	1	1	2	1	4	2	2	1	5	5			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr8:110441662C>T	uc003yne.2	+	26	3198	c.3094C>T	c.(3094-3096)CTA>TTA	p.L1032L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1032	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACTTGGAGACCTACTTCGTAC	0.323										HNSCC(38;0.096)			4	8					0	0	0	0	T	110441662	T	T	110441662	2	4	254	1	0	0	0	0	0	0	0	1	12027	680	24	4		4	PKHD1L1	8	110441662	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08		110441662	35922360	36	46439											
GTF3C4	9329	broad.mit.edu	37	chr9	135553693	135553693	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctctaaaaatgaggccccGgaaggaaatctcggggattt	12	9	11	9	2	2	1	0	1	2	0	4	4	2	4	2	5	0	0	2	5	5	2	rs138509726	byFrequency	TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr9:135553693G>A	uc010mzv.2	+	2	945	c.687G>A	c.(685-687)CCG>CCA	p.P229P	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	229					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		ATGAGGCCCCGGAAGGAAATC	0.517													37	29					0	0	0	0	A	135553693	A	A	135553693	2	1	254	1	0	0	0	0	0	0	0	1	6914	1103	39	1		1	GTF3C4	9	135553693	Silent	SNP	G	TCGA-CV-7416-01A-11D-2078-08		135553693	5659738	37	46440											
FBXO18	84893	broad.mit.edu	37	chr10	5951214	5951214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctccccgaggctgaggCgtgtgtgcggcaacacctcc	5	7	12	17	3	0	1	0	1	0	0	3	2	3	1	6	3	2	2	6	3	1	0			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr10:5951214C>T	uc001iis.2	+	5	1072	c.977C>T	c.(976-978)GCG>GTG	p.A326V	FBXO18_uc001iir.2_Missense_Mutation_p.A252V|FBXO18_uc009xig.2_Missense_Mutation_p.A252V|FBXO18_uc001iit.2_Missense_Mutation_p.A377V	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	326					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						GAGGCTGAGGCGTGTGTGCGG	0.612													11	19					0	0	0	0	T	5951214	T	T	5951214	3	4	254	1	0	0	0	0	1	0	0	0	5763	768	27	1	1157	1	FBXO18	10	5951214	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08		5951214	129583533	38	46441											
KIAA1462	57608	broad.mit.edu	37	chr10	30317939	30317939	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggctgaccgctggccccagCcttctcggtcggagactgct	5	8	13	15	3	1	2	0	1	1	1	3	3	1	2	4	4	2	3	4	4	0	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr10:30317939C>A	uc001iux.2	-	2	1197	c.1138G>T	c.(1138-1140)GCT>TCT	p.A380S	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.A242S|KIAA1462_uc009xle.1_Missense_Mutation_p.A380S	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	380	Pro-rich.									ovary(4)	4						CTGGCCCCAGCCTTCTCGGTC	0.632													7	90					8.12818e-05	8.73027e-05	1	0	A	30317939	A	A	30317939	3	1	254	1	0	0	0	0	1	0	0	0	8273	739	26	4	2949	4	KIAA1462	10	30317939	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	24366725	30317939	105216808	39	46442											
COL17A1	1308	broad.mit.edu	37	chr10	105812854	105812854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggtcccatggggccttctCgccctctctggcccatgggg	3	9	14	15	1	2	0	0	0	2	0	5	1	3	0	4	6	0	0	4	6	0	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr10:105812854C>T	uc001kxr.2	-	23	2043	c.1874G>A	c.(1873-1875)CGA>CAA	p.R625Q	COL17A1_uc010qqv.1_Missense_Mutation_p.R609Q	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	625	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGGGCCTTCTCGCCCTCTCTG	0.597													34	50					0	0	0	0	T	105812854	T	T	105812854	3	4	254	1	0	0	0	0	1	0	0	0	3689	884	31	1	2755	1	COL17A1	10	105812854	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	75494915	105812854	29721893	40	46443											
ADAM12	8038	broad.mit.edu	37	chr10	127786990	127786990	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcccttggcttaccatgaCaattcccccagactggtctg	8	11	8	14	0	1	2	0	1	1	1	2	2	2	2	4	2	2	1	4	2	2	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr10:127786990C>A	uc001ljk.2	-	10	1413	c.1000G>T	c.(1000-1002)GTC>TTC	p.V334F	ADAM12_uc010qul.1_Missense_Mutation_p.V285F|ADAM12_uc001ljm.2_Missense_Mutation_p.V334F|ADAM12_uc001ljn.2_Missense_Mutation_p.V331F|ADAM12_uc001ljl.3_Missense_Mutation_p.V331F	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	334	Extracellular (Potential).|Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CTTACCATGACAATTCCCCCA	0.483													43	75					2.01872e-29	2.2735e-29	1	0	A	127786990	A	A	127786990	3	1	254	1	0	0	0	0	1	0	0	0	236	478	17	4	1893	4	ADAM12	10	127786990	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	21974136	127786990	7747757	41	46444											
OR51I1	390063	broad.mit.edu	37	chr11	5461808	5461808	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttcagccttcctcaggcctGggatttatggaagaacttga	9	12	10	10	0	2	2	2	1	0	1	3	4	3	4	3	3	2	0	3	3	3	5			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr11:5461808G>C	uc010qze.1	-	1	937	c.937C>G	c.(937-939)CAG>GAG	p.Q313E	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTCAGGCCTGGGATTTATGG	0.463													7	34					0	0	0	0	C	5461808	C	C	5461808	3	2	254	1	0	0	0	0	1	0	0	0	11154	1357	47	4	11	4	OR51I1	11	5461808	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08		5461808	129544708	42	46445											
KCNC1	3746	broad.mit.edu	37	chr11	17793574	17793574	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgtgctgggcttcctgcgCgtcgtccgcttcgtgcgcat	2	11	14	14	7	0	0	0	0	0	0	4	1	2	0	2	1	3	4	2	1	0	2	rs76882721	byFrequency	TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr11:17793574C>T	uc001mnk.3	+	2	988	c.933C>T	c.(931-933)CGC>CGT	p.R311R	KCNC1_uc009yhc.1_Silent_p.R311R	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	311	Helical; Voltage-sensor; Name=Segment S4; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						GCTTCCTGCGCGTCGTCCGCT	0.627													3	19					0	0	0	0	T	17793574	T	T	17793574	2	4	254	1	0	0	0	0	0	0	0	1	8053	755	27	1		1	KCNC1	11	17793574	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08	12331766	17793574	117212942	43	46446											
HTATIP2	10553	broad.mit.edu	37	chr11	20404742	20404742	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggaaagcgcatggctctctCaagccatgaccacattggag	11	7	12	11	1	2	1	1	1	1	0	3	3	2	3	2	3	2	2	2	3	2	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr11:20404742C>G	uc009yia.1	+	6	786	c.720C>G	c.(718-720)CTC>CTG	p.L240L	HTATIP2_uc009yib.1_Silent_p.L240L|HTATIP2_uc001mpx.2_Silent_p.L274L|HTATIP2_uc001mpz.2_Silent_p.L240L	NM_006410	NP_006401	Q9BUP3	HTAI2_HUMAN	HIV-1 Tat interactive protein 2, 30kDa isoform	240					angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity				0						ATGGCTCTCTCAAGCCATGAC	0.443													4	5					0	0	0	0	G	20404742	G	G	20404742	2	3	254	1	0	0	0	0	0	0	0	1	7471	813	29	2		2	HTATIP2	11	20404742	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08	2611168	20404742	114601774	44	46447											
OR8H3	390152	broad.mit.edu	37	chr11	55890111	55890111	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccttagcgaacttactgaCttccaactatatttccttca	12	14	3	12	1	1	1	1	1	0	0	3	2	3	1	3	0	5	0	3	0	7	7			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr11:55890111C>T	uc001nii.1	+	1	263	c.263C>T	c.(262-264)ACT>ATT	p.T88I		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					AACTTACTGACTTCCAACTAT	0.423													69	290					0	0	0	0	T	55890111	T	T	55890111	3	4	254	1	0	0	0	0	1	0	0	0	11293	565	20	4	265	4	OR8H3	11	55890111	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	35485369	55890111	79116405	45	46448											
PGA5	5222	broad.mit.edu	37	chr11	61018663	61018663	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtccccaccgaatctggagaGctttggatcctgggtgatgt	7	11	13	10	1	1	2	0	1	1	1	3	5	3	3	4	3	1	1	4	3	1	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr11:61018663G>T	uc001nqz.2	+	9	1107	c.1077G>T	c.(1075-1077)GAG>GAT	p.E359D		NM_014224	NP_055039	P00790	PEPA_HUMAN	pepsinogen 5, group I precursor	359					digestion|proteolysis	extracellular region	aspartic-type endopeptidase activity			skin(1)	1						AATCTGGAGAGCTTTGGATCC	0.552													31	139					4.62619e-21	5.15998e-21	1	0	T	61018663	T	T	61018663	3	4	254	1	0	0	0	0	1	0	0	0	11827	962	34	4	1111	4	PGA5	11	61018663	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	5128552	61018663	73987853	46	46449											
IQSEC3	440073	broad.mit.edu	37	chr12	247432	247432	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctctgtcctcgtccttgcaGattgaaatgctagaacataa	11	13	7	10	1	1	3	0	1	1	2	5	3	3	3	2	0	3	2	2	0	4	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr12:247432G>A	uc001qhw.1	+						IQSEC3_uc001qhu.1_Splice_Site|IQSEC3_uc001qht.1_Splice_Site_p.I84_splice|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3						regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CGTCCTTGCAGATTGAAATGC	0.612													3	28					0	0	0	0	A	247432	A	A	247432	1	1	254	0	1	0	0	0	0	0	0	0	7858	956	33	2		2	IQSEC3	12	247432	5'Flank	SNP	G	TCGA-CV-7416-01A-11D-2078-08		247432	133604463	47	46450											
CACNA2D4	93589	broad.mit.edu	37	chr12	1995395	1995405	+	Frame_Shift_Del	DEL	GATATTAATGA	-	-																															gaaggcacatttaccgctatGatattaatgaagtcattctc																								rs10735005	by1000genomes	TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr12:1995395_1995405delGATATTAATGA	uc001qjp.2	-	8	1208_1218	c.977_987delTCATTAATATC	c.(976-987)TTCATTAATATCfs	p.F326fs	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Intron	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	326_329	VWFA.|Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TTACCGCTATGATATTAATGAAGTCATTCTC	0.498													---	---	---								-	1995405	-	-	1995395	7	5	254	1	0	1	0	1	0	0	0	0	2563	1280	45	0	2550	0	CACNA2D4	12	1995395	Frame_Shift_Del	DEL	GATATTAATGA	TCGA-CV-7416-01A-11D-2078-08	1747963	1995395	131856500	48	46451											
OR9K2	441639	broad.mit.edu	37	chr12	55523868	55523868	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catctgttattgaacccaagGctatgatcaacttctggtct	10	14	7	10	0	4	2	1	2	3	0	4	2	4	2	1	2	2	2	1	2	5	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr12:55523868G>T	uc010spe.1	+	1	316	c.316G>T	c.(316-318)GCT>TCT	p.A106S		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	106	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						TGAACCCAAGGCTATGATCAA	0.423													19	70					2.35188e-11	2.5497e-11	1	0	T	55523868	T	T	55523868	3	4	254	1	0	0	0	0	1	0	0	0	11308	1203	42	4	318	4	OR9K2	12	55523868	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	53528473	55523868	78328027	49	46452											
ORAI1	84876	broad.mit.edu	37	chr12	122079507	122079507	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacaggaccagctggaccaCagaggggaccaccccctgac	11	4	11	15	0	0	2	0	1	0	1	0	5	0	5	5	4	2	1	5	4	1	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr12:122079507C>G	uc010szz.1	+	3	1057	c.864C>G	c.(862-864)CAC>CAG	p.H288Q		NM_032790	NP_116179	Q96D31	CRCM1_HUMAN	calcium release-activated calcium channel	288	Cytoplasmic (Potential).				platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		AGCTGGACCACAGAGGGGACC	0.612													19	62					0	0	0	0	G	122079507	G	G	122079507	3	3	254	1	0	0	0	0	1	0	0	0	11311	477	17	4	876	4	ORAI1	12	122079507	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	66555639	122079507	11772388	50	46453											
DGKH	160851	broad.mit.edu	37	chr13	42761205	42761205	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacgctatgtgaaactgtaaAggacttcgttgccaaagtag	13	10	11	7	2	0	1	0	1	0	0	1	3	0	2	1	1	2	4	1	1	6	5			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr13:42761205A>C	uc001uyl.1	+	14	1580	c.1559A>C	c.(1558-1560)AAG>ACG	p.K520T	DGKH_uc010tfh.1_Missense_Mutation_p.K520T|DGKH_uc001uym.1_Missense_Mutation_p.K520T|DGKH_uc010tfi.1_Missense_Mutation_p.K275T|DGKH_uc010tfj.1_Missense_Mutation_p.K375T|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.K375T|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	520					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		GAAACTGTAAAGGACTTCGTT	0.373													14	51					0	0	0	0	C	42761205	C	C	42761205	3	2	254	1	0	0	0	0	1	0	0	0	4492	72	3	5	1613	5	DGKH	13	42761205	Missense_Mutation	SNP	A	TCGA-CV-7416-01A-11D-2078-08		42761205	72408673	51	46454											
TRMT5	57570	broad.mit.edu	37	chr14	61442681	61442696	+	Frame_Shift_Del	DEL	TTCTTTGCTACTGGAA	-	-																															tggcaaatacagtgcagtttTtctttgctactggaatggca																										TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr14:61442681_61442696delTTCTTTGCTACTGGAA	uc001xff.3	-	4	1032_1047	c.941_956delTTCCAGTAGCAAAGAA	c.(940-957)ATTCCAGTAGCAAAGAAAfs	p.I314fs		NM_020810	NP_065861	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	314_319						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			central_nervous_system(2)|large_intestine(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		AGTGCAGTTTTTCTTTGCTACTGGAATGGCAAAGGG	0.417													---	---	---								-	61442696	-	-	61442681	7	5	254	1	0	1	0	1	0	0	0	0	16634	1841	64	0	581	0	TRMT5	14	61442681	Frame_Shift_Del	DEL	TTCTTTGCTACTGGAA	TCGA-CV-7416-01A-11D-2078-08		61442681	45906859	52	46455											
NRXN3	9369	broad.mit.edu	37	chr14	80164200	80164200	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgacctccatgccaccagaaAtgtctactactgtcatggaa	12	9	7	13	1	2	1	1	0	1	1	3	3	3	2	4	1	3	0	4	1	4	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr14:80164200A>C	uc001xun.2	+	15	3216	c.2725A>C	c.(2725-2727)ATG>CTG	p.M909L	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.M277L|NRXN3_uc010asw.2_Missense_Mutation_p.M307L|NRXN3_uc001xur.3_Missense_Mutation_p.M277L	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1282	Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCCACCAGAAATGTCTACTAC	0.453													8	47					0	0	0	0	C	80164200	C	C	80164200	3	2	254	1	0	0	0	0	1	0	0	0	10721	101	4	5	3120	5	NRXN3	14	80164200	Missense_Mutation	SNP	A	TCGA-CV-7416-01A-11D-2078-08	18721519	80164200	27185340	53	46456											
HERC2	8924	broad.mit.edu	37	chr15	28517376	28517376	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcacgtgcatgtcgccctcGgagtggggtgcatccttcct	4	11	12	14	3	1	0	1	0	0	0	5	1	3	1	3	3	2	2	3	3	0	1	rs141677977		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:28517376G>A	uc001zbj.2	-	9	1174	c.1068C>T	c.(1066-1068)TCC>TCT	p.S356S	HERC2_uc001zbl.1_Silent_p.S51S	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	356					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TGTCGCCCTCGGAGTGGGGTG	0.527													3	24					0	0	0	0	A	28517376	A	A	28517376	2	1	254	1	0	0	0	0	0	0	0	1	7097	1103	39	1		1	HERC2	15	28517376	Silent	SNP	G	TCGA-CV-7416-01A-11D-2078-08		28517376	74014016	54	46457											
UBR1	197131	broad.mit.edu	37	chr15	43330042	43330042	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcaaccaacaccagacaacGtaaaggatattccactagta	17	6	7	11	1	0	1	0	0	0	1	1	2	1	2	3	2	3	3	3	2	8	5			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:43330042G>A	uc001zqq.2	-	17	2017	c.1951C>T	c.(1951-1953)CGT>TGT	p.R651C	UBR1_uc010udk.1_Missense_Mutation_p.R651C	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	651					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		ACCAGACAACGTAAAGGATAT	0.393													4	22					0	0	0	0	A	43330042	A	A	43330042	3	1	254	1	0	0	0	0	1	0	0	0	16969	1145	40	1	3422	1	UBR1	15	43330042	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	14812666	43330042	59201350	55	46458											
ITGA11	22801	broad.mit.edu	37	chr15	68624774	68624774	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcagtcacgccgtcgccgtCgatgtccaccgaggtgattt	7	10	11	13	6	2	1	2	1	0	0	5	3	3	1	4	1	0	0	4	1	0	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:68624774C>T	uc002ari.2	-	13	1555	c.1468G>A	c.(1468-1470)GAC>AAC	p.D490N	ITGA11_uc010bib.2_Missense_Mutation_p.D490N	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	490	FG-GAP 5.|Potential.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	CCGTCGCCGTCGATGTCCACC	0.602													6	9					0	0	0	0	T	68624774	T	T	68624774	3	4	254	1	0	0	0	0	1	0	0	0	7913	884	31	1	2170	1	ITGA11	15	68624774	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	25294732	68624774	33906618	56	46459											
C15orf27	123591	broad.mit.edu	37	chr15	76496314	76496314	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcactgcccgcgaggagccGtcctctgagcccggcccttc	5	6	12	18	4	1	1	0	1	1	0	3	3	2	2	5	2	4	1	5	2	0	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:76496314G>A	uc002bbq.2	+	11	1409	c.1254G>A	c.(1252-1254)CCG>CCA	p.P418P	C15orf27_uc010bkp.2_Silent_p.P234P|C15orf27_uc002bbr.2_Silent_p.P234P|C15orf27_uc002bbs.2_Silent_p.P96P	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	418						integral to membrane					0						GCGAGGAGCCGTCCTCTGAGC	0.701													10	28					0	0	0	0	A	76496314	A	A	76496314	2	1	254	1	0	0	0	0	0	0	0	1	1794	1132	40	1		1	C15orf27	15	76496314	Silent	SNP	G	TCGA-CV-7416-01A-11D-2078-08	7871540	76496314	26035078	57	46460											
SCAPER	49855	broad.mit.edu	37	chr15	76957999	76957999	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggtatttaaggtacctgaaGttcatccgggcttttatctt	8	16	10	7	1	2	1	1	1	1	0	3	1	3	1	2	3	1	4	2	3	5	8			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:76957999G>C	uc002bby.2	-	20	2699	c.2640C>G	c.(2638-2640)AAC>AAG	p.N880K	SCAPER_uc010bkr.2_Missense_Mutation_p.N188K|SCAPER_uc002bbx.2_Missense_Mutation_p.N634K|SCAPER_uc002bbz.1_Missense_Mutation_p.N751K|SCAPER_uc002bca.1_Missense_Mutation_p.N745K	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	879						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						GGTACCTGAAGTTCATCCGGG	0.328													2	3					0	0	0	0	C	76957999	C	C	76957999	3	2	254	1	0	0	0	0	1	0	0	0	13943	1020	36	4	1610	4	SCAPER	15	76957999	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	461685	76957999	25573393	58	46461											
IL16	3603	broad.mit.edu	37	chr15	81598782	81598782	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagaggccacagtctgcaCggtgacactggagaagatgt	12	6	14	9	1	1	4	0	1	1	3	1	5	1	4	1	3	2	2	1	3	1	0			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:81598782C>T	uc002bgh.3	+	18	4077	c.3701C>T	c.(3700-3702)ACG>ATG	p.T1234M	IL16_uc010blq.1_Missense_Mutation_p.T1188M|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.T1275M|IL16_uc002bgg.2_Missense_Mutation_p.T1233M|IL16_uc002bgi.1_Missense_Mutation_p.T623M|IL16_uc002bgj.2_Missense_Mutation_p.T727M|IL16_uc002bgk.2_Missense_Mutation_p.T533M|IL16_uc002bgl.1_Missense_Mutation_p.T533M|IL16_uc010unq.1_Missense_Mutation_p.T532M	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	1234	PDZ 4.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						ACAGTCTGCACGGTGACACTG	0.577													5	100					0	0	0	0	T	81598782	T	T	81598782	3	4	254	1	0	0	0	0	1	0	0	0	7672	536	19	1	3767	1	IL16	15	81598782	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	4640783	81598782	20932610	59	46462											
C15orf32	145858	broad.mit.edu	37	chr15	93016181	93016181	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcctctcttgttttccacAgacacatcctcgacccaaag	9	13	4	15	1	1	1	0	0	1	1	6	2	4	1	4	0	0	1	4	0	1	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr15:93016181A>G	uc002brc.1	+	2	847	c.375_splice	c.e2-2	p.R125_splice	C15orf32_uc010bod.1_Splice_Site	NM_153040	NP_694585	Q32M92	CO032_HUMAN	hypothetical protein LOC145858											ovary(1)	1	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			TGTTTTCCACAGACACATCCT	0.493													21	68					0	0	0	0	G	93016181	G	G	93016181	5	3	254	1	0	0	0	0	0	0	1	0	1796	202	7	5	379	5	C15orf32	15	93016181	Splice_Site	SNP	A	TCGA-CV-7416-01A-11D-2078-08	11417399	93016181	9515211	60	46463											
MTSS1L	92154	broad.mit.edu	37	chr16	70712271	70712271	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caggtacatgtcgttgacgtCctgcagggcactgtccagct	7	10	12	12	2	0	1	0	1	0	0	3	1	2	1	2	2	3	5	2	2	1	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr16:70712271C>T	uc002ezj.2	-	8	768	c.508G>A	c.(508-510)GAC>AAC	p.D170N	MTSS1L_uc002ezk.1_Missense_Mutation_p.D87N	NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	170	IMD.				filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						TCGTTGACGTCCTGCAGGGCA	0.662													12	46					0	0	0	0	T	70712271	T	T	70712271	3	4	254	1	0	0	0	0	1	0	0	0	10016	855	30	2	1767	2	MTSS1L	16	70712271	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08		70712271	19642482	61	46464											
CHST6	4166	broad.mit.edu	37	chr16	75512907	75512907	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggctcccgcgccaggtcctCgaagcgcaccaggcggtagc	6	4	14	17	6	0	0	0	0	0	0	3	1	2	0	4	4	2	3	4	4	2	1	rs72547538		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr16:75512907C>T	uc002fef.2	-	3	1000	c.820G>A	c.(820-822)GAG>AAG	p.E274K	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.E274K	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	274	Lumenal (Potential).		E -> K (in MCD; abolishes ability to sulfate keratan).		keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GCCAGGTCCTCGAAGCGCACC	0.672													5	60					0	0	0	0	T	75512907	T	T	75512907	3	4	254	1	0	0	0	0	1	0	0	0	3423	893	31	1	371	1	CHST6	16	75512907	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	4800636	75512907	14841846	62	46465											
CNTNAP4	85445	broad.mit.edu	37	chr16	76513352	76513352	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtgaagcctataagcacaGaggaaatacttcagggtttt	14	11	10	6	0	1	2	1	1	0	1	1	3	1	3	1	2	3	2	1	2	5	6			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr16:76513352G>A	uc002feu.1	+	14	2184	c.1799G>A	c.(1798-1800)AGA>AAA	p.R600K	CNTNAP4_uc002fev.1_Missense_Mutation_p.R464K|CNTNAP4_uc010chb.1_Missense_Mutation_p.R527K|CNTNAP4_uc002fex.1_Missense_Mutation_p.R603K|CNTNAP4_uc002few.2_Missense_Mutation_p.R575K	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	600	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TATAAGCACAGAGGAAATACT	0.343													16	81					0	0	0	0	A	76513352	A	A	76513352	3	1	254	1	0	0	0	0	1	0	0	0	3664	942	33	2	1858	2	CNTNAP4	16	76513352	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	1000445	76513352	13841401	63	46466											
OR1D2	4991	broad.mit.edu	37	chr17	2995956	2995966	+	Frame_Shift_Del	DEL	TTGTCCAGGGC	-	-																															ccatcacagccaggatgaggTtgtccagggccaccaaggag																								rs138671819		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:2995956_2995966delTTGTCCAGGGC	uc010vrb.1	-	1	325_335	c.325_335delGCCCTGGACAA	c.(325-336)GCCCTGGACAACfs	p.A109fs		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	109_112	Helical; Name=3; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CAGGATGAGGTTGTCCAGGGCCACCAAGGAG	0.54													---	---	---								-	2995966	-	-	2995956	7	5	254	1	0	1	0	1	0	0	0	0	11007	1725	60	0	606	0	OR1D2	17	2995956	Frame_Shift_Del	DEL	TTGTCCAGGGC	TCGA-CV-7416-01A-11D-2078-08		2995956	78199254	64	46467											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	7	7	13	14	3	3	0	3	0	0	0	4	0	4	0	3	3	3	2	3	3	1	0	rs28934578		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	21					0	0	0	0	T	7578406	T	T	7578406	3	4	254	1	0	0	0	0	1	0	0	0	16448	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	4582450	7578406	73616804	65	46468											
TAOK1	57551	broad.mit.edu	37	chr17	27849481	27849481	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatataataagcgaagagaaCgagaactaagacgaaagcat	22	5	9	5	3	0	3	0	0	0	3	0	7	0	3	0	0	4	1	0	0	9	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:27849481C>T	uc002hdz.1	+	17	2286	c.2092C>T	c.(2092-2094)CGA>TGA	p.R698*	TAOK1_uc010wbe.1_Intron|TAOK1_uc010wbf.1_Nonsense_Mutation_p.R698*	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	698					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			GCGAAGAGAACGAGAACTAAG	0.428													12	48					0	0	0	0	T	27849481	T	T	27849481	4	4	254	1	0	0	0	0	0	1	0	0	15613	528	19	1	2154	1	TAOK1	17	27849481	Nonsense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	20271075	27849481	53345729	66	46469											
KRT24	192666	broad.mit.edu	37	chr17	38855898	38855898	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctgtgtcagccagggttcCctccagggagcttttctaag	6	13	11	11	0	3	0	1	0	2	0	5	1	5	1	3	2	2	2	3	2	1	5			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:38855898C>T	uc002hvd.2	-	6	1216	c.1159G>A	c.(1159-1161)GGA>AGA	p.G387R		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	387	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				GCCAGGGTTCCCTCCAGGGAG	0.423													29	55					0	0	0	0	T	38855898	T	T	38855898	3	4	254	1	0	0	0	0	1	0	0	0	8500	632	22	4	430	4	KRT24	17	38855898	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	11006417	38855898	42339312	67	46470											
KIF19	124602	broad.mit.edu	37	chr17	72322500	72322500	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgcaatcatgaaggacagCggggactccaaggaccagca	13	4	13	11	1	1	1	1	1	0	0	2	4	2	4	2	4	3	3	2	4	3	0			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:72322500C>T	uc002jkm.3	+	1	150	c.12C>T	c.(10-12)AGC>AGT	p.S4S	KIF19_uc002jkj.2_Silent_p.S4S|KIF19_uc002jkk.2_Silent_p.S4S|KIF19_uc002jkl.2_Silent_p.S4S	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	4					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						TGAAGGACAGCGGGGACTCCA	0.672													11	51					0	0	0	0	T	72322500	T	T	72322500	2	4	254	1	0	0	0	0	0	0	0	1	8321	767	27	1		1	KIF19	17	72322500	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08	33466602	72322500	8872710	68	46471											
CCDC40	55036	broad.mit.edu	37	chr17	78073373	78073373	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acacgccttaagcacctgcaGgctgtgaaggaggggcgcta	10	6	14	11	2	0	1	0	1	0	0	0	2	0	2	2	4	2	4	2	4	3	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr17:78073373G>A	uc010dht.2	+	20	3255	c.3228G>A	c.(3226-3228)CAG>CAA	p.Q1076Q	CCDC40_uc002jxm.3_Silent_p.Q859Q|CCDC40_uc002jxn.3_Silent_p.Q472Q|GAA_uc002jxo.2_5'Flank|GAA_uc002jxp.2_5'Flank|GAA_uc002jxq.2_5'Flank	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1076					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGCACCTGCAGGCTGTGAAGG	0.572													13	41					0	0	0	0	A	78073373	A	A	78073373	2	1	254	1	0	0	0	0	0	0	0	1	2825	991	35	4		4	CCDC40	17	78073373	Silent	SNP	G	TCGA-CV-7416-01A-11D-2078-08	5750873	78073373	3121837	69	46472											
TMEM161A	54929	broad.mit.edu	37	chr19	19231608	19231608	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaagtgtgcagttgagggtGaggatgagcggcgtcaggta	10	8	19	4	2	1	4	1	3	0	1	1	5	1	5	0	4	2	3	0	4	2	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:19231608G>A	uc002nlg.2	-	11	1182	c.1152C>T	c.(1150-1152)CTC>CTT	p.L384L	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Silent_p.L359L|TMEM161A_uc002nli.2_Silent_p.L281L|TMEM161A_uc002nlj.2_Silent_p.L259L	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	384	Helical; (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			AGTTGAGGGTGAGGATGAGCG	0.612													7	46					0	0	0	0	A	19231608	A	A	19231608	2	1	254	1	0	0	0	0	0	0	0	1	16142	1277	45	2		2	TMEM161A	19	19231608	Silent	SNP	G	TCGA-CV-7416-01A-11D-2078-08		19231608	39897375	70	46473											
ZNF493	284443	broad.mit.edu	37	chr19	21607093	21607093	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attcacactggagaaaaaccCtacaaatgtgaagaatgtgg	17	8	9	7	0	1	3	1	1	0	2	1	4	1	3	1	2	2	0	1	2	6	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:21607093C>A	uc002npx.2	+	2	1528	c.1248C>A	c.(1246-1248)CCC>CCA	p.P416P	ZNF493_uc002npw.2_Silent_p.P544P|ZNF493_uc002npy.2_Silent_p.P416P	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAGAAAAACCCTACAAATGTG	0.358													4	11					0.00909568	0.00942053	1	0	A	21607093	A	A	21607093	2	1	254	1	0	0	0	0	0	0	0	1	18011	668	24	4		4	ZNF493	19	21607093	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08	2375485	21607093	37521890	71	46474											
RYR1	6261	broad.mit.edu	37	chr19	38948883	38948883	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctggggcggcaacggggtCggcgatgacctctattccta	6	8	16	11	4	1	1	0	1	1	0	3	2	2	1	2	7	1	2	2	7	3	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:38948883C>T	uc002oit.2	+	18	2248	c.2118C>T	c.(2116-2118)GTC>GTT	p.V706V	RYR1_uc002oiu.2_Silent_p.V706V	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	706	Cytoplasmic.|B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCAACGGGGTCGGCGATGACC	0.657													24	51					0	0	0	0	T	38948883	T	T	38948883	2	4	254	1	0	0	0	0	0	0	0	1	13833	871	31	1		1	RYR1	19	38948883	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08	17341790	38948883	20180100	72	46475											
SHKBP1	92799	broad.mit.edu	37	chr19	41086523	41086527	+	Frame_Shift_Del	DEL	GGATC	-	-																															ggtgtgtggacaccataattGgatcgctgtggcctataccc																										TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:41086523_41086527delGGATC	uc002oob.2	+	8	663_667	c.614_618delGGATC	c.(613-618)TGGATCfs	p.W205fs	SHKBP1_uc002ooc.2_Frame_Shift_Del_p.W205fs|SHKBP1_uc002ood.2_Frame_Shift_Del_p.W205fs|SHKBP1_uc010xvl.1_Frame_Shift_Del_p.W128fs|SHKBP1_uc002ooe.2_Frame_Shift_Del_p.W42fs|SHKBP1_uc002oof.2_Frame_Shift_Del_p.W42fs|SHKBP1_uc010xvm.1_Frame_Shift_Del_p.W42fs|SHKBP1_uc010xvn.1_Frame_Shift_Del_p.W83fs	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	205_206						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CACCATAATTGGATCGCTGTGGCCT	0.595													---	---	---								-	41086527	-	-	41086523	7	5	254	1	0	1	0	1	0	0	0	0	14349	1357	47	0	644	0	SHKBP1	19	41086523	Frame_Shift_Del	DEL	GGATC	TCGA-CV-7416-01A-11D-2078-08	2137640	41086523	18042460	73	46476											
KPTN	11133	broad.mit.edu	37	chr19	47984035	47984035	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctactggtcaggttcgtcAgctctgggaagaggttttcc	7	12	12	10	1	3	1	2	0	1	1	5	2	4	2	2	4	2	3	2	4	2	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:47984035A>G	uc002pgy.2	-	6	685	c.581T>C	c.(580-582)CTG>CCG	p.L194P	KPTN_uc010xys.1_RNA	NM_007059	NP_008990	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	194					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			ovary(1)	1		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		CAGGTTCGTCAGCTCTGGGAA	0.587													25	101					0	0	0	0	G	47984035	G	G	47984035	3	3	254	1	0	0	0	0	1	0	0	0	8476	188	7	5	757	5	KPTN	19	47984035	Missense_Mutation	SNP	A	TCGA-CV-7416-01A-11D-2078-08	6897512	47984035	11144948	74	46477											
DBP	1628	broad.mit.edu	37	chr19	49134221	49134221	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaggaaggccgcccgcaccGatatctggttctccttgagc	7	8	11	15	3	2	1	0	1	2	0	3	3	2	2	5	3	1	2	5	3	2	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:49134221G>A	uc002pjx.3	-	4	1239	c.851C>T	c.(850-852)TCG>TTG	p.S284L	DBP_uc002pjy.2_3'UTR	NM_001352	NP_001343	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box)	284					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		CGCCCGCACCGATATCTGGTT	0.647													3	8					0	0	0	0	A	49134221	A	A	49134221	3	1	254	1	0	0	0	0	1	0	0	0	4273	1059	37	1	130	1	DBP	19	49134221	Missense_Mutation	SNP	G	TCGA-CV-7416-01A-11D-2078-08	1150186	49134221	9994762	75	46478											
PPP2R1A	5518	broad.mit.edu	37	chr19	52722988	52722988	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctctaacctggactgtgtGaacgaggtgattggcatccg	9	11	12	9	2	1	2	0	2	1	0	3	4	2	3	2	3	2	1	2	3	2	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:52722988G>A	uc002pyp.2	+	10	1332	c.1173G>A	c.(1171-1173)GTG>GTA	p.V391V	PPP2R1A_uc010ydk.1_Silent_p.V336V|PPP2R1A_uc002pyq.2_Silent_p.V212V	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	391	PP2A subunit B binding.|HEAT 10.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TGGACTGTGTGAACGAGGTGA	0.577			Mis		clear cell ovarian carcinoma								11	22					0	0	0	0	A	52722988	A	A	52722988	2	1	254	1	0	0	0	0	0	0	0	1	12442	1277	45	2		2	PPP2R1A	19	52722988	Silent	SNP	G	TCGA-CV-7416-01A-11D-2078-08	3588767	52722988	6405995	76	46479											
ZNF667	63934	broad.mit.edu	37	chr19	56952582	56952582	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtcgaatcagggatgaactCcgactatatgccttcccaca	11	10	8	12	2	1	1	1	1	0	0	4	4	3	2	3	1	2	0	3	1	4	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:56952582C>A	uc002qnd.2	-	5	1944	c.1782G>T	c.(1780-1782)CGG>CGT	p.R594R	ZNF667_uc010etl.2_Silent_p.R376R|ZNF667_uc002qne.2_Silent_p.R594R|ZNF667_uc010etm.2_Silent_p.R537R	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	594	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GGGATGAACTCCGACTATATG	0.388													21	42					7.87624e-14	8.61929e-14	1	0	A	56952582	A	A	56952582	2	1	254	1	0	0	0	0	0	0	0	1	18141	842	30	2		2	ZNF667	19	56952582	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08	4229594	56952582	2176401	77	46480											
ZNF329	79673	broad.mit.edu	37	chr19	58639326	58639326	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttggaacatttttccacaCtgaggacaccggctgggacc	9	11	10	11	1	0	1	0	1	0	0	1	4	1	4	3	4	1	1	3	4	1	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr19:58639326C>T	uc002qrn.2	-	4	1782	c.1545G>A	c.(1543-1545)CAG>CAA	p.Q515Q	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	515	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TTTTTCCACACTGAGGACACC	0.512													29	72					0	0	0	0	T	58639326	T	T	58639326	2	4	254	1	0	0	0	0	0	0	0	1	17914	564	20	4		4	ZNF329	19	58639326	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08	1686744	58639326	489657	78	46481											
SAMHD1	25939	broad.mit.edu	37	chr20	35580031	35580032	+	In_Frame_Ins	INS	-	ATC	ATC																															cgcttggagggctgctcggaINSatcggctcgctgcatggcta																										TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr20:35580031_35580032insATC	uc002xgh.1	-	1	145_146	c.15_16insGAT	c.(13-18)insGAT	p.5_6insD		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	5_6					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				GGCTGCTCGGAATCGGCTCGCT	0.693													---	---	---								ATC	35580032	ATC	ATC	35580031	7	5	254	1	0	1	1	0	0	0	0	0	13893	246	9	0	1928	0	SAMHD1	20	35580031	In_Frame_Ins	INS	-	TCGA-CV-7416-01A-11D-2078-08		35580031	27445489	79	46482											
COL18A1	80781	broad.mit.edu	37	chr21	46899995	46899995	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgttcccagggagaccctggGgttggagagagagggccccc	7	6	17	11	0	0	3	0	0	0	3	1	6	1	3	4	5	0	2	4	5	0	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr21:46899995G>A	uc011afs.1	+	10	2589	c.2568G>A	c.(2566-2568)GGG>GGA	p.G856G	COL18A1_uc002zhg.2_Silent_p.G441G|COL18A1_uc002zhi.2_Silent_p.G621G	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	856	Triple-helical region 2 (COL2).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GAGACCCTGGGGTTGGAGAGA	0.502													3	47					0	0	0	0	A	46899995	A	A	46899995	2	1	254	1	0	0	0	0	0	0	0	1	3690	1219	43	4		4	COL18A1	21	46899995	Silent	SNP	G	TCGA-CV-7416-01A-11D-2078-08		46899995	1229900	80	46483											
CECR1	51816	broad.mit.edu	37	chr22	17670900	17670900	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccattcggatggattctgCgatgacagccacatctttgg	8	11	12	10	2	2	1	0	1	2	0	3	4	2	3	2	4	2	0	2	4	0	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr22:17670900C>T	uc002zmk.1	-	5	1116	c.904G>A	c.(904-906)GCA>ACA	p.A302T	CECR1_uc010gqu.1_Missense_Mutation_p.A302T|CECR1_uc011agi.1_Missense_Mutation_p.A260T|CECR1_uc011agj.1_3'UTR|CECR1_uc002zmj.1_Missense_Mutation_p.A61T	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	302					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				ATGGATTCTGCGATGACAGCC	0.577													10	37					0	0	0	0	T	17670900	T	T	17670900	3	4	254	1	0	0	0	0	1	0	0	0	3220	768	27	1	651	1	CECR1	22	17670900	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08		17670900	33633666	81	46484											
GNB1L	54584	broad.mit.edu	37	chr22	19789706	19789706	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caccgatccatcctcatagcCggccagaaggagtgggcggg	9	5	14	13	3	1	1	1	0	0	1	3	3	3	2	5	4	1	0	5	4	2	1			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr22:19789706C>T	uc002zqe.1	-	6	944	c.550G>A	c.(550-552)GGC>AGC	p.G184S	GNB1L_uc002zqd.1_Missense_Mutation_p.G40S|GNB1L_uc002zqf.1_Missense_Mutation_p.G184S	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	184	WD 3.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					TCCTCATAGCCGGCCAGAAGG	0.622													12	31					0	0	0	0	T	19789706	T	T	19789706	3	4	254	1	0	0	0	0	1	0	0	0	6553	652	23	1	441	1	GNB1L	22	19789706	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	2118806	19789706	31514860	82	46485											
MCAT	27349	broad.mit.edu	37	chr22	43539128	43539128	+	Frame_Shift_Del	DEL	C	-	-																															tgagcagaccgcggcccatgCccaccacctggctgccctgg																										TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chr22:43539128delC	uc003bdl.1	-	1	276	c.227delG	c.(226-228)GGCfs	p.G76fs	MCAT_uc003bdm.1_Frame_Shift_Del_p.G76fs	NM_173467	NP_775738	Q8IVS2	FABD_HUMAN	mitochondrial malonyltransferase isoform a	76					fatty acid biosynthetic process	mitochondrion	[acyl-carrier-protein] S-malonyltransferase activity|binding			ovary(1)	1		Ovarian(80;0.0694)				GCGGCCCATGCCCACCACCTG	0.746													---	---	---								-	43539128	-	-	43539128	7	5	254	1	0	1	0	1	0	0	0	0	9425	739	26	0	961	0	MCAT	22	43539128	Frame_Shift_Del	DEL	C	TCGA-CV-7416-01A-11D-2078-08	23749422	43539128	7765438	83	46486											
POLA1	5422	broad.mit.edu	37	chrX	24745918	24745918	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagctcttgaatcagccagtCagttggtgtaaagttgaggc	10	11	13	7	0	3	2	2	2	1	0	3	3	3	2	1	2	2	4	1	2	3	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:24745918C>G	uc004dbl.2	+	15	1556	c.1533C>G	c.(1531-1533)GTC>GTG	p.V511V	POLA1_uc004dbm.2_Silent_p.V517V|POLA1_uc004dbn.2_Silent_p.V375V	NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	511					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	ATCAGCCAGTCAGTTGGTGTA	0.388													8	46					0	0	0	0	G	24745918	G	G	24745918	2	3	254	1	0	0	0	0	0	0	0	1	12242	813	29	2		2	POLA1	23	24745918	Silent	SNP	C	TCGA-CV-7416-01A-11D-2078-08		24745918	130524642	84	46487											
ZC4H2	55906	broad.mit.edu	37	chrX	64196325	64196325	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaagggatacaatagacaCaatgtagccacctcctccgg	13	6	9	13	1	0	1	0	0	0	1	2	2	2	2	5	2	2	1	5	2	6	3			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:64196325C>T	uc004dvu.2	-	1	21	c.-67G>A	c.(-69--65)TTGTG>TTATG		ZC4H2_uc004dvv.2_Intron|ZC4H2_uc011mov.1_Translation_Start_Site|ZC4H2_uc011mow.1_Translation_Start_Site|ZC4H2_uc004dvw.1_Translation_Start_Site	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing								metal ion binding|protein binding			ovary(1)	1						ACAATAGACACAATGTAGCCA	0.527													10	20					0	0	0	0	T	64196325	T	T	64196325	1	4	254	1	0	0	0	0	0	0	0	0	17645	493	17	4		4	ZC4H2	23	64196325	Translation_Start_Site	SNP	C	TCGA-CV-7416-01A-11D-2078-08	39450407	64196325	91074235	85	46488											
FAM155B	27112	broad.mit.edu	37	chrX	68749788	68749788	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctagaggagggcctgacaCgggaagagtgacagtaggga	12	4	17	8	1	0	4	0	2	0	2	0	7	0	7	2	4	0	1	2	4	3	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:68749788C>T	uc004dxk.2	+	3	1456	c.1408C>T	c.(1408-1410)CGG>TGG	p.R470W		NM_015686	NP_056501	O75949	F155B_HUMAN	transmembrane protein 28	471						integral to membrane				ovary(1)|breast(1)	2						GGGCCTGACACGGGAAGAGTG	0.632													3	21					0	0	0	0	T	68749788	T	T	68749788	3	4	254	1	0	0	0	0	1	0	0	0	5494	527	19	1	1418	1	FAM155B	23	68749788	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	4553463	68749788	86520772	86	46489											
BRWD3	254065	broad.mit.edu	37	chrX	79960224	79960224	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctttcttctagggactTcaaattttcctcatcagagc	8	15	6	12	0	5	1	3	0	2	1	6	2	6	2	2	1	2	0	2	1	2	6			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:79960224T>A	uc004edt.2	-	23	2937	c.2674A>T	c.(2674-2676)AAG>TAG	p.K892*	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edp.2_Nonsense_Mutation_p.K721*|BRWD3_uc004edq.2_Nonsense_Mutation_p.K488*|BRWD3_uc010nmj.1_Nonsense_Mutation_p.K488*|BRWD3_uc004edr.2_Nonsense_Mutation_p.K562*|BRWD3_uc004eds.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edu.2_Nonsense_Mutation_p.K562*|BRWD3_uc004edv.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edw.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edx.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edy.2_Nonsense_Mutation_p.K488*|BRWD3_uc004edz.2_Nonsense_Mutation_p.K562*|BRWD3_uc004eea.2_Nonsense_Mutation_p.K562*|BRWD3_uc004eeb.2_Nonsense_Mutation_p.K488*	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	892										ovary(4)	4						TCTAGGGACTTCAAATTTTCC	0.348													16	444					0	0	0	0	A	79960224	A	A	79960224	4	1	254	1	0	0	0	0	0	1	0	0	1531	1792	62	5	2810	5	BRWD3	23	79960224	Nonsense_Mutation	SNP	T	TCGA-CV-7416-01A-11D-2078-08	11210436	79960224	75310336	87	46490											
BRWD3	254065	broad.mit.edu	37	chrX	80001189	80001189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagggaaaatatgaccaaagCgactacagccggttaattgc	16	7	10	8	2	0	1	0	1	0	0	0	3	0	2	2	2	4	1	2	2	7	4			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:80001189C>T	uc004edt.2	-	7	733	c.470G>A	c.(469-471)CGC>CAC	p.R157H	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_5'UTR|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_Intron|BRWD3_uc004edr.2_5'UTR|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_5'UTR|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_5'UTR|BRWD3_uc004eea.2_5'UTR|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	157										ovary(4)	4						ATGACCAAAGCGACTACAGCC	0.373													184	15					0	0	0	0	T	80001189	T	T	80001189	3	4	254	1	0	0	0	0	1	0	0	0	1531	768	27	1	5078	1	BRWD3	23	80001189	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	40965	80001189	75269371	88	46491											
POU3F4	5456	broad.mit.edu	37	chrX	82763808	82763808	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctccagctgccgcctctgCacagagcctgcacccggtgc	6	6	10	19	2	1	1	0	0	1	1	2	1	2	1	6	1	6	3	6	1	0	0			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:82763808C>T	uc004eeg.2	+	1	540	c.476C>T	c.(475-477)GCA>GTA	p.A159V		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	159					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCGCCTCTGCACAGAGCCTG	0.657													6	63					0	0	0	0	T	82763808	T	T	82763808	3	4	254	1	0	0	0	0	1	0	0	0	12332	710	25	4	478	4	POU3F4	23	82763808	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	2762619	82763808	72506752	89	46492											
TEX13A	56157	broad.mit.edu	37	chrX	104463741	104463741	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acaccaagggcagtcccagtCccctggcctgcgatatactg	9	7	10	15	1	0	0	0	0	0	0	2	1	2	0	5	2	2	1	5	2	3	2			TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:104463741C>T	uc004ema.2	-	5	1247	c.1135G>A	c.(1135-1137)GAC>AAC	p.D379N	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_3'UTR	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	379	RanBP2-type.					intracellular	zinc ion binding			ovary(2)	2						CAGTCCCAGTCCCCTGGCCTG	0.532													11	83					0	0	0	0	T	104463741	T	T	104463741	3	4	254	1	0	0	0	0	1	0	0	0	15842	842	30	2	98	2	TEX13A	23	104463741	Missense_Mutation	SNP	C	TCGA-CV-7416-01A-11D-2078-08	21699933	104463741	50806819	90	46493											
MAGEC1	9947	broad.mit.edu	37	chrX	140995293	140995293	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcagagtcctcttgagggAgaggactccctgtcttctct	6	12	10	13	0	4	3	1	1	3	2	7	5	6	4	3	2	0	0	3	2	0	2	rs147024850		TCGA-CV-7416-01A-11D-2078-08	TCGA-CV-7416-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80c86be4-ccbe-4bf5-afcf-644cd337d37a	061150b2-1c4a-4126-9e7c-e9088d04db80	g.chrX:140995293A>T	uc004fbt.2	+	4	2389	c.2103A>T	c.(2101-2103)GGA>GGT	p.G701G	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	701							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTCTTGAGGGAGAGGACTCCC	0.567										HNSCC(15;0.026)			19	43					0	0	0	0	T	140995293	T	T	140995293	2	4	254	1	0	0	0	0	0	0	0	1	9233	291	11	5		5	MAGEC1	23	140995293	Silent	SNP	A	TCGA-CV-7416-01A-11D-2078-08	36531552	140995293	14275267	91	46494											
PLEKHM2	23207	broad.mit.edu	37	chr1	16046240	16046240	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctcctcaggatgccccttaCctagacctggccccctacat	7	10	6	18	0	2	1	1	0	1	1	3	2	2	2	7	2	3	0	7	2	3	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:16046240C>T	uc010obo.1	+	6	704	c.477C>T	c.(475-477)TAC>TAT	p.Y159Y		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	159	Interaction with KIF5B.				Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ATGCCCCTTACCTAGACCTGG	0.607													27	20					0	0	0	0	T	16046240	T	T	16046240	2	4	255	1	0	0	0	0	0	0	0	1	12136	518	18	4		4	PLEKHM2	1	16046240	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08		16046240	233204381	1	46495											
SRRM1	10250	broad.mit.edu	37	chr1	24978993	24978993	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	accttctccggaaaaaaattCcaaaaaagaaaaggagaagg	21	5	8	7	1	1	2	0	0	1	2	3	4	2	3	3	3	0	0	3	3	9	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:24978993C>G	uc001bjm.2	+	7	1018	c.794C>G	c.(793-795)TCC>TGC	p.S265C	SRRM1_uc010oel.1_Missense_Mutation_p.S265C|SRRM1_uc009vrh.1_Missense_Mutation_p.S226C|SRRM1_uc009vri.1_Missense_Mutation_p.S182C|SRRM1_uc010oem.1_RNA	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	265	Pro-rich.|Arg-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		GAAAAAAATTCCAAAAAAGAA	0.448													10	11					0	0	0	0	G	24978993	G	G	24978993	3	3	255	1	0	0	0	0	1	0	0	0	15234	855	30	2	820	2	SRRM1	1	24978993	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	8932753	24978993	224271628	2	46496											
COL16A1	1307	broad.mit.edu	37	chr1	32140630	32140630	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taaggaggtgctgttcaattGgtaaggatccctgcaagaga	12	10	13	6	0	1	1	1	0	0	1	2	4	2	3	1	4	2	4	1	4	4	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:32140630G>C	uc001btk.1	-	44	3202	c.2837C>G	c.(2836-2838)CCA>CGA	p.P946R	COL16A1_uc001btj.1_Missense_Mutation_p.P759R	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	946	Nonhelical region 4 (NC4).				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CTGTTCAATTGGTAAGGATCC	0.542													7	11					0	0	0	0	C	32140630	C	C	32140630	3	2	255	1	0	0	0	0	1	0	0	0	3688	1348	47	4	2089	4	COL16A1	1	32140630	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	7161637	32140630	217109991	3	46497											
CYP2J2	1573	broad.mit.edu	37	chr1	60392390	60392390	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccactgcccagagggcaGccgccagagagcccatcgcc	9	2	13	17	2	0	2	0	0	0	2	1	4	0	3	6	2	3	1	6	2	0	0	rs146801076	byFrequency	TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:60392390G>A	uc001czq.2	-	1	34	c.29C>T	c.(28-30)GCT>GTT	p.A10V		NM_000775	NP_000766	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J,	10					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			ovary(1)	1	all_cancers(7;0.000396)					CCAGAGGGCAGCCGCCAGAGA	0.607													4	9					0	0	0	0	A	60392390	A	A	60392390	3	1	255	1	0	0	0	0	1	0	0	0	4189	971	34	4	1515	4	CYP2J2	1	60392390	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	28251760	60392390	188858231	4	46498											
ATP1A4	480	broad.mit.edu	37	chr1	160156092	160156095	+	Frame_Shift_Del	DEL	CCTA	-	-																															ctggtggctctgtgccattcCctacagtattctcatcttcg																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:160156092_160156095delCCTA	uc001fve.3	+	21	3475_3478	c.2996_2999delCCTA	c.(2995-3000)CCCTACfs	p.P999fs	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Frame_Shift_Del_p.P502fs|ATP1A4_uc001fvh.2_Frame_Shift_Del_p.P135fs	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	999_1000	Helical; (Potential).			ITWWLCAIPYSILIFVYDEIRKLLIRQ -> WSFALTAQAG VKWRILGLLQPLPPRFK (in Ref. 6; BAC05228).	ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTGCCATTCCCTACAGTATTCTC	0.549													---	---	---								-	160156095	-	-	160156092	7	5	255	1	0	1	0	1	0	0	0	0	1133	623	22	0	3078	0	ATP1A4	1	160156092	Frame_Shift_Del	DEL	CCTA	TCGA-CV-7418-01A-11D-2078-08	99763702	160156092	89094529	5	46499											
GPR161	23432	broad.mit.edu	37	chr1	168074064	168074068	+	Frame_Shift_Del	DEL	AGCTG	-	-																															attactcagctccttcctgcAgctgagggaggagttgaggc																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:168074064_168074068delAGCTG	uc001gfc.2	-	4	335_339	c.21_25delCAGCT	c.(19-27)CTCAGCTGCfs	p.L7fs	GPR161_uc001gfb.2_Intron|GPR161_uc010pll.1_Intron|GPR161_uc010plm.1_Intron|GPR161_uc009wvo.2_Frame_Shift_Del_p.L24fs|GPR161_uc001gfd.2_Frame_Shift_Del_p.L7fs|GPR161_uc010pln.1_Frame_Shift_Del_p.L27fs|GPR161_uc001gfe.1_Frame_Shift_Del_p.L7fs	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	7_9	Extracellular (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					TCCTTCCTGCAGCTGAGGGAGGAGT	0.561													---	---	---								-	168074068	-	-	168074064	7	5	255	1	0	1	0	1	0	0	0	0	6703	188	7	0	1584	0	GPR161	1	168074064	Frame_Shift_Del	DEL	AGCTG	TCGA-CV-7418-01A-11D-2078-08	7917972	168074064	81176557	6	46500											
ASPM	259266	broad.mit.edu	37	chr1	197091324	197091324	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtatttgacatatctgaatGattaatcatagcaggtattc	13	16	7	5	0	2	3	1	3	1	0	3	3	2	3	0	1	1	3	0	1	6	7			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:197091324G>T	uc001gtu.2	-	15	3963	c.3706C>A	c.(3706-3708)CAT>AAT	p.H1236N	ASPM_uc001gtv.2_Missense_Mutation_p.H1236N|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1236					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ATATCTGAATGATTAATCATA	0.308													10	40					0.000978159	0.00102756	1	0	T	197091324	T	T	197091324	3	4	255	1	0	0	0	0	1	0	0	0	1058	1290	45	2	6783	2	ASPM	1	197091324	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	29017260	197091324	52159297	7	46501											
ZC3H11A	9877	broad.mit.edu	37	chr1	203786208	203786208	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctacccagcatgcctaatCaaggagaagactgctatttt	13	11	7	10	0	2	2	1	0	1	2	2	3	2	2	2	1	4	2	2	1	5	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:203786208C>G	uc001hac.2	+	5	626	c.10C>G	c.(10-12)CAA>GAA	p.Q4E	ZC3H11A_uc001had.2_Missense_Mutation_p.Q4E|ZC3H11A_uc001hae.2_Missense_Mutation_p.Q4E|ZC3H11A_uc001haf.2_Missense_Mutation_p.Q4E|ZC3H11A_uc010pqm.1_Intron|ZC3H11A_uc001hag.1_Missense_Mutation_p.Q4E	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	4	C3H1-type 1.						nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CATGCCTAATCAAGGAGAAGA	0.388													16	89					0	0	0	0	G	203786208	G	G	203786208	3	3	255	1	0	0	0	0	1	0	0	0	17627	827	29	2	12	2	ZC3H11A	1	203786208	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	6694884	203786208	45464413	8	46502											
TMCC2	9911	broad.mit.edu	37	chr1	205210771	205210771	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagcagcagggtatgtccGaccatgactccccagatgag	11	6	12	12	1	0	3	0	2	0	1	2	4	2	3	4	1	3	4	4	1	1	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:205210771G>T	uc001hbz.1	+	3	790	c.346G>T	c.(346-348)GAC>TAC	p.D116Y	TMCC2_uc010prf.1_Missense_Mutation_p.D38Y	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	116						integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GGGTATGTCCGACCATGACTC	0.637													6	38					0.00116845	0.00121518	1	0	T	205210771	T	T	205210771	3	4	255	1	0	0	0	0	1	0	0	0	16059	1058	37	3	352	3	TMCC2	1	205210771	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	1424563	205210771	44039850	9	46503											
NID1	4811	broad.mit.edu	37	chr1	236205526	236205526	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacgtctgcaggcaccacGccattggtggtggctggact	7	9	13	12	2	2	0	1	0	1	0	2	1	2	1	2	5	1	3	2	5	0	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:236205526G>A	uc001hxo.2	-	4	921	c.819C>T	c.(817-819)GGC>GGT	p.G273G	NID1_uc009xgd.2_Silent_p.G273G	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	273					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CAGGCACCACGCCATTGGTGG	0.557													59	152					0	0	0	0	A	236205526	A	A	236205526	2	1	255	1	0	0	0	0	0	0	0	1	10468	1074	38	1		1	NID1	1	236205526	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	30994755	236205526	13045095	10	46504											
OR2M3	127062	broad.mit.edu	37	chr1	248367254	248367254	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctacagcctccgcaacaaGgaggtgaccagagcattcat	13	7	9	12	1	2	2	1	1	1	1	3	3	3	3	3	2	4	2	3	2	3	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:248367254G>A	uc010pzg.1	+	1	885	c.885G>A	c.(883-885)AAG>AAA	p.K295K		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCCGCAACAAGGAGGTGACCA	0.458													30	83					0	0	0	0	A	248367254	A	A	248367254	2	1	255	1	0	0	0	0	0	0	0	1	11065	991	35	4		4	OR2M3	1	248367254	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	12161728	248367254	883367	11	46505											
OR2T1	26696	broad.mit.edu	37	chr1	248569576	248569576	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgcactgatggccaatggggTtatgatcttcctgatccaaa	10	11	10	10	1	1	3	0	3	1	0	3	3	3	3	3	3	0	2	3	3	3	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr1:248569576T>A	uc010pzm.1	+	1	281	c.281T>A	c.(280-282)GTT>GAT	p.V94D		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	94	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCAATGGGGTTATGATCTTC	0.428													20	136					0	0	0	0	A	248569576	A	A	248569576	3	1	255	1	0	0	0	0	1	0	0	0	11070	1725	60	5	283	5	OR2T1	1	248569576	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	202322	248569576	681045	12	46506											
EHBP1	23301	broad.mit.edu	37	chr2	63086416	63086417	+	Frame_Shift_Ins	INS	-	GACTCAGA	GACTCAGA																															taaatccatttggagatcctINSgactcagaaggtagcaagtt																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr2:63086416_63086417insGACTCAGA	uc002sby.2	+	9	1334_1335	c.852_853insGACTCAGA	c.(850-855)CCTGACfs	p.P284fs	EHBP1_uc010fcp.2_Frame_Shift_Ins_p.P249fs|EHBP1_uc002sbx.2_Frame_Shift_Ins_p.P249fs|EHBP1_uc002sbz.2_Frame_Shift_Ins_p.P249fs|EHBP1_uc002scb.2_Frame_Shift_Ins_p.P249fs	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	284_285						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TTGGAGATCCTGACTCAGAAGG	0.361									Hereditary_Prostate_Cancer				---	---	---								GACTCAGA	63086417	GACTCAGA	GACTCAGA	63086416	7	5	255	1	0	1	1	0	0	0	0	0	4997	1567	55	0	882	0	EHBP1	2	63086416	Frame_Shift_Ins	INS	-	TCGA-CV-7418-01A-11D-2078-08		63086416	180112957	13	46507											
ZRANB3	84083	broad.mit.edu	37	chr2	135988170	135988170	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagactacattgccagccctCtacaggaaaggctggggtgg	10	7	14	10	0	1	1	0	0	1	1	1	3	1	2	2	5	4	1	2	5	3	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr2:135988170C>G	uc002tum.2	-	13	1984	c.1867G>C	c.(1867-1869)GAG>CAG	p.E623Q	ZRANB3_uc002tuk.2_Missense_Mutation_p.E166Q|ZRANB3_uc002tul.2_Missense_Mutation_p.E623Q	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	623	RanBP2-type.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		TGCCAGCCCTCTACAGGAAAG	0.488													21	35					0	0	0	0	G	135988170	G	G	135988170	3	3	255	1	0	0	0	0	1	0	0	0	18291	922	32	2	1408	2	ZRANB3	2	135988170	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	72901754	135988170	107211203	14	46508											
THSD7B	80731	broad.mit.edu	37	chr2	137814502	137814502	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctttggtggtttgcaatgtCcaaatctgactgagtcaaga	10	14	10	7	0	3	3	1	2	2	1	4	3	4	3	1	2	1	2	1	2	3	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr2:137814502C>A	uc002tva.1	+	2	559	c.559C>A	c.(559-561)CCA>ACA	p.P187T	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.P77T	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTTGCAATGTCCAAATCTGAC	0.478													58	136					1.22119e-34	1.48542e-34	1	0	A	137814502	A	A	137814502	3	1	255	1	0	0	0	0	1	0	0	0	15946	855	30	2	565	2	THSD7B	2	137814502	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	1826332	137814502	105384871	15	46509											
KIF5C	3800	broad.mit.edu	37	chr2	149847689	149847689	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcgagcgggagctggcaGcctgccagctgctcatctcc	6	6	13	16	2	2	0	1	0	1	0	3	2	2	1	4	2	7	4	4	2	0	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr2:149847689G>T	uc010zbu.1	+	16	2250	c.1882G>T	c.(1882-1884)GCC>TCC	p.A628S	KIF5C_uc002tws.1_RNA|KIF5C_uc002twt.2_Missense_Mutation_p.A180S	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	628					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		GGAGCTGGCAGCCTGCCAGCT	0.587													6	16					3.59834e-05	3.91861e-05	1	0	T	149847689	T	T	149847689	3	4	255	1	0	0	0	0	1	0	0	0	8346	971	34	4	1866	4	KIF5C	2	149847689	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	12033187	149847689	93351684	16	46510											
KCNH7	90134	broad.mit.edu	37	chr2	163374317	163374317	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcatggaccgaagatgctCtccgtatactacataagctt	12	12	7	10	2	2	1	1	0	1	1	3	3	2	2	2	1	4	3	2	1	6	6			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr2:163374317C>A	uc002uch.1	-	4	1027	c.815G>T	c.(814-816)AGA>ATA	p.R272I	KCNH7_uc002uci.2_Missense_Mutation_p.R272I	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	272	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	CGAAGATGCTCTCCGTATACT	0.458													5	53					5.9392e-07	6.57103e-07	1	0	A	163374317	A	A	163374317	3	1	255	1	0	0	0	0	1	0	0	0	8076	913	32	2	2893	2	KCNH7	2	163374317	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	13526628	163374317	79825056	17	46511											
LRP2	4036	broad.mit.edu	37	chr2	169989168	169989168	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggacttccataattcttattAtccacattttcagatacagt	12	16	4	9	0	2	1	1	0	1	1	4	2	4	2	2	1	1	0	2	1	4	8			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr2:169989168A>G	uc002ues.2	-	77	13857	c.13644T>C	c.(13642-13644)GAT>GAC	p.D4548D		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4548	Cytoplasmic (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AATTCTTATTATCCACATTTT	0.383													25	52					0	0	0	0	G	169989168	G	G	169989168	2	3	255	1	0	0	0	0	0	0	0	1	9006	446	16	5		5	LRP2	2	169989168	Silent	SNP	A	TCGA-CV-7418-01A-11D-2078-08	6614851	169989168	73210205	18	46512											
ZNF804A	91752	broad.mit.edu	37	chr2	185731223	185731223	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatcacattaattcatatgAccatgctcacaagcaggtaa	16	10	5	10	0	3	1	3	1	0	0	3	1	3	1	1	1	2	3	1	1	5	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr2:185731223A>G	uc002uph.2	+	2	833	c.239A>G	c.(238-240)GAC>GGC	p.D80G		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	80	C2H2-type.					intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AATTCATATGACCATGCTCAC	0.358													15	74					0	0	0	0	G	185731223	G	G	185731223	3	3	255	1	0	0	0	0	1	0	0	0	18237	275	10	5	245	5	ZNF804A	2	185731223	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	15742055	185731223	57468150	19	46513											
SLC40A1	30061	broad.mit.edu	37	chr2	190428622	190428622	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaccaaaccacattttcgacGtagccaagtaaaagctacag	17	7	6	11	2	0	0	0	0	0	0	1	1	0	0	3	0	5	3	3	0	7	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr2:190428622G>A	uc002uqp.3	-	7	1441	c.1090C>T	c.(1090-1092)CGT>TGT	p.R364C		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	364					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			CATTTTCGACGTAGCCAAGTA	0.468													18	111					0	0	0	0	A	190428622	A	A	190428622	3	1	255	1	0	0	0	0	1	0	0	0	14692	1145	40	1	633	1	SLC40A1	2	190428622	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	4697399	190428622	52770751	20	46514											
CUL3	8452	broad.mit.edu	37	chr2	225368470	225368470	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataataacgttcaaatacatCtttttcttgcataaacctaa	16	15	2	8	1	3	0	1	0	2	0	3	0	3	0	1	0	4	2	1	0	7	9			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr2:225368470C>G	uc002vny.2	-	9	1660	c.1276G>C	c.(1276-1278)GAT>CAT	p.D426H	CUL3_uc010zls.1_Missense_Mutation_p.D360H|CUL3_uc010fwy.1_Missense_Mutation_p.D432H	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	426					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TCAAATACATCTTTTTCTTGC	0.294													7	4					0	0	0	0	G	225368470	G	G	225368470	3	3	255	1	0	0	0	0	1	0	0	0	4073	913	32	2	1062	2	CUL3	2	225368470	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	34939848	225368470	17830903	21	46515											
CYP8B1	1582	broad.mit.edu	37	chr3	42917176	42917176	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttccggaaagccatggcatGgccaagccagggcacggtac	10	5	13	13	2	0	0	0	0	0	0	1	1	1	1	4	5	3	3	4	5	3	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:42917176G>T	uc003cmh.2	-	1	458	c.133C>A	c.(133-135)CAT>AAT	p.H45N	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Missense_Mutation_p.H45N	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	45					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		GCCATGGCATGGCCAAGCCAG	0.577													28	25					7.26314e-15	8.43985e-15	1	0	T	42917176	T	T	42917176	3	4	255	1	0	0	0	0	1	0	0	0	4215	1348	47	4	1376	4	CYP8B1	3	42917176	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08		42917176	155105254	22	46516											
KIAA1143	57456	broad.mit.edu	37	chr3	44795015	44795015	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gactggttttcgatatatgaTtcttccatcggctggagttg	7	16	11	7	2	1	1	0	1	1	0	4	4	2	2	1	3	0	3	1	3	2	7			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-11A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	269e1950-5b9e-4b06-9dbe-d809e280243b	g.chr3:44795015T>C	uc011bac.1	-	3	362	c.283A>G	c.(283-285)ATC>GTC	p.I95V		NM_020696	NP_065747	Q96AT1	K1143_HUMAN	hypothetical protein LOC57456	95											0				BRCA - Breast invasive adenocarcinoma(193;0.00847)|KIRC - Kidney renal clear cell carcinoma(197;0.0465)|Kidney(197;0.0582)		CGATATATGATTCTTCCATCG	0.343													3	41					0	0	0	0	C	44795015	C	C	44795015	3	2	255	1	0	0	0	0	1	0	0	0	8248	1493	52	5	185	5	KIAA1143	3	44795015	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	1877839	44795015	153227415	23	46517											
CELSR3	1951	broad.mit.edu	37	chr3	48694603	48694603	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatgttgaagatgaagacGtcctcagcgggcgtagcgag	10	8	16	7	4	1	4	1	2	0	2	2	6	2	5	1	2	2	2	1	2	3	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:48694603G>A	uc003cul.2	-	2	4208	c.3927C>T	c.(3925-3927)GAC>GAT	p.D1309D	CELSR3_uc003cuf.1_Silent_p.D1379D	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1309	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGATGAAGACGTCCTCAGCGG	0.657													9	14					0	0	0	0	A	48694603	A	A	48694603	2	1	255	1	0	0	0	0	0	0	0	1	3238	1136	40	1		1	CELSR3	3	48694603	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	3899588	48694603	149327827	24	46518											
FILIP1L	11259	broad.mit.edu	37	chr3	99569270	99569270	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcttttactgagtttttcaAcctctagtttaaagtcttta	9	21	4	7	0	4	1	1	1	3	0	4	1	4	1	1	0	2	2	1	0	6	10			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:99569270A>C	uc003dtm.2	-	5	1713	c.1250T>G	c.(1249-1251)GTT>GGT	p.V417G	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Missense_Mutation_p.V417G|FILIP1L_uc010hpf.2_5'UTR|FILIP1L_uc010hpg.2_Missense_Mutation_p.V177G|FILIP1L_uc003dtn.2_Missense_Mutation_p.V177G|FILIP1L_uc003dtp.1_Missense_Mutation_p.V177G	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	417	Potential.					cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						GAGTTTTTCAACCTCTAGTTT	0.368													45	46					0	0	0	0	C	99569270	C	C	99569270	3	2	255	1	0	0	0	0	1	0	0	0	5927	43	2	5	2186	5	FILIP1L	3	99569270	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	50874667	99569270	98453160	25	46519											
RG9MTD1	54931	broad.mit.edu	37	chr3	101283915	101283915	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctagctgccaccagagagtTcattgagatgtggagattgc	10	11	12	8	0	2	3	1	1	1	3	2	6	2	3	2	1	3	2	2	1	1	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:101283915T>G	uc003duz.2	+	2	438	c.290T>G	c.(289-291)TTC>TGC	p.F97C		NM_017819	NP_060289	Q7L0Y3	MRRP1_HUMAN	RNA (guanine-9-) methyltransferase domain	97					tRNA processing	mitochondrion	methyltransferase activity|protein binding			ovary(1)	1						ACCAGAGAGTTCATTGAGATG	0.403													14	60					0	0	0	0	G	101283915	G	G	101283915	3	3	255	1	0	0	0	0	1	0	0	0	13336	1783	62	5	292	5	RG9MTD1	3	101283915	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	1714645	101283915	96738515	26	46520											
SNX4	8723	broad.mit.edu	37	chr3	125172710	125172710	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttcatttatttgttcttcTagcacctttattctggcttc	5	21	4	11	0	4	0	1	0	3	0	5	0	4	0	2	1	1	3	2	1	3	11			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:125172710T>C	uc003eib.2	-	12	1176	c.1134A>G	c.(1132-1134)CTA>CTG	p.L378L	SNX4_uc011bkf.1_Silent_p.L233L	NM_003794	NP_003785	O95219	SNX4_HUMAN	sorting nexin 4	378					cell communication|endocytic recycling|endocytosis|protein transport	cytoplasmic dynein complex|early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4						TTTGTTCTTCTAGCACCTTTA	0.393													20	46					0	0	0	0	C	125172710	C	C	125172710	2	2	255	1	0	0	0	0	0	0	0	1	14968	1509	53	5		5	SNX4	3	125172710	Silent	SNP	T	TCGA-CV-7418-01A-11D-2078-08	23888795	125172710	72849720	27	46521											
COL6A6	131873	broad.mit.edu	37	chr3	130283910	130283910	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caatggaagtgaggagaactTtgactatcttaaaggattct	14	12	10	5	0	2	3	0	2	2	1	2	6	2	5	0	3	1	0	0	3	6	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:130283910T>C	uc010htl.2	+	3	765	c.734T>C	c.(733-735)TTT>TCT	p.F245S		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	245	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GAGGAGAACTTTGACTATCTT	0.418													43	83					0	0	0	0	C	130283910	C	C	130283910	3	2	255	1	0	0	0	0	1	0	0	0	3718	1841	64	5	744	5	COL6A6	3	130283910	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	5111200	130283910	67738520	28	46522											
IL20RB	53833	broad.mit.edu	37	chr3	136708366	136708366	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggacctggggccccagtttGagttccttgtggcctactgg	5	11	14	11	0	0	1	0	1	0	0	1	2	1	2	5	5	1	2	5	5	1	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:136708366G>C	uc003eri.1	+	4	739	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	IL20RB_uc003erj.1_RNA|IL20RB_uc010hud.1_Missense_Mutation_p.E22Q	NM_144717	NP_653318	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta precursor	164	Extracellular (Potential).|Fibronectin type-III 2.					integral to membrane	receptor activity			ovary(1)	1						GCCCCAGTTTGAGTTCCTTGT	0.567													12	39					0	0	0	0	C	136708366	C	C	136708366	3	2	255	1	0	0	0	0	1	0	0	0	7708	1291	45	2	504	2	IL20RB	3	136708366	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	6424456	136708366	61314064	29	46523											
COPB2	9276	broad.mit.edu	37	chr3	139092255	139092255	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcaggttcctcccgaccaagCtgaaagaaagaaaaatagct	16	6	9	10	1	0	3	0	1	0	2	2	4	2	3	3	1	2	4	3	1	6	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:139092255C>A	uc003etf.3	-	9	1025	c.895_splice	c.e9-1	p.L299_splice	COPB2_uc011bmv.1_Splice_Site_p.L270_splice|COPB2_uc010hui.2_Splice_Site_p.L270_splice	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta						COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						CCCGACCAAGCTGAAAGAAAG	0.408													9	29					3.09899e-07	3.447e-07	1	0	A	139092255	A	A	139092255	5	1	255	1	0	0	0	0	0	0	1	0	3744	811	28	4	1882	4	COPB2	3	139092255	Splice_Site	SNP	C	TCGA-CV-7418-01A-11D-2078-08	2383889	139092255	58930175	30	46524											
SGEF	26084	broad.mit.edu	37	chr3	153840472	153840472	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agaacgagctcctcgagaatCcttccgtggttttgagtaca	10	11	10	10	3	0	3	0	1	0	2	4	5	3	3	3	1	3	3	3	1	3	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:153840472C>G	uc011bog.1	+	2	902	c.691C>G	c.(691-693)CCT>GCT	p.P231A	uc003ezu.1_5'Flank|SGEF_uc011boh.1_Missense_Mutation_p.P231A	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	231					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CCTCGAGAATCCTTCCGTGGT	0.542													12	16					0	0	0	0	G	153840472	G	G	153840472	3	3	255	1	0	0	0	0	1	0	0	0	14270	855	30	2	693	2	SGEF	3	153840472	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	14748217	153840472	44181958	31	46525											
SLC33A1	9197	broad.mit.edu	37	chr3	155551699	155551699	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggctggggacctgcagtgtaTttgctgataatcagaggcag	9	10	15	7	0	1	2	1	1	0	1	1	3	1	3	1	4	2	5	1	4	2	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:155551699T>C	uc003fan.3	-	3	1476	c.1095A>G	c.(1093-1095)AAA>AAG	p.K365K	SLC33A1_uc003fao.1_Silent_p.K365K	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	365	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CTGCAGTGTATTTGCTGATAA	0.388													16	38					0	0	0	0	C	155551699	C	C	155551699	2	2	255	1	0	0	0	0	0	0	0	1	14630	1490	52	5		5	SLC33A1	3	155551699	Silent	SNP	T	TCGA-CV-7418-01A-11D-2078-08	1711227	155551699	42470731	32	46526											
GOLIM4	27333	broad.mit.edu	37	chr3	167747722	167747722	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcttcctggtgttcccgcaGctgctgggcctcctccacct	3	11	10	17	1	0	0	0	0	0	0	4	0	4	0	6	2	3	5	6	2	0	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:167747722G>C	uc003ffe.2	-	10	1623	c.1279C>G	c.(1279-1281)CTG>GTG	p.L427V	GOLIM4_uc011bpe.1_Missense_Mutation_p.L427V|GOLIM4_uc011bpf.1_Missense_Mutation_p.L399V|GOLIM4_uc011bpg.1_Missense_Mutation_p.L399V	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	427	Glu-rich.|Gln-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						tgttcccgcagctgctgGGCC	0.308													30	112					0	0	0	0	C	167747722	C	C	167747722	3	2	255	1	0	0	0	0	1	0	0	0	6603	962	34	4	839	4	GOLIM4	3	167747722	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	12196023	167747722	30274708	33	46527											
KLHL24	54800	broad.mit.edu	37	chr3	183369021	183369021	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaagcaagacggtaccacAtacttgggaatgaaatgatg	16	8	11	6	1	0	4	0	3	0	1	0	5	0	5	1	2	3	2	1	2	6	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr3:183369021A>G	uc003flv.2	+	3	1172	c.877A>G	c.(877-879)ATA>GTA	p.I293V	KLHL24_uc003flw.2_Missense_Mutation_p.I293V|KLHL24_uc003flx.2_Missense_Mutation_p.I293V	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	293						axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			ACGGTACCACATACTTGGGAA	0.388													13	48					0	0	0	0	G	183369021	G	G	183369021	3	3	255	1	0	0	0	0	1	0	0	0	8418	217	8	5	879	5	KLHL24	3	183369021	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	15621299	183369021	14653409	34	46528											
TBCK	93627	broad.mit.edu	37	chr4	107165855	107165855	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gctctttctccaagtcacctCcagccaaacaccaaaggtaa	13	8	5	15	0	3	0	1	0	2	0	5	0	4	0	5	1	2	2	5	1	4	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr4:107165855C>G	uc010ilv.2	-	11	1363	c.998G>C	c.(997-999)GGA>GCA	p.G333A	TBCK_uc003hyb.2_Missense_Mutation_p.G76A|TBCK_uc003hye.2_Missense_Mutation_p.G294A|TBCK_uc003hyc.2_Missense_Mutation_p.G270A|TBCK_uc003hyd.2_Missense_Mutation_p.G161A|TBCK_uc003hyf.2_Missense_Mutation_p.G333A	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	333						intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						CAAGTCACCTCCAGCCAAACA	0.363													18	12					0	0	0	0	G	107165855	G	G	107165855	3	3	255	1	0	0	0	0	1	0	0	0	15702	855	30	2	1747	2	TBCK	4	107165855	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08		107165855	83988421	35	46529											
GAB1	2549	broad.mit.edu	37	chr4	144361302	144361303	+	Frame_Shift_Ins	INS	-	T	T																															gaaaattacgtcccaatgaaINStcccaattcaccaccacgac																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr4:144361302_144361303insT	uc003ije.2	+	6	1711_1712	c.1352_1353insT	c.(1351-1353)AATfs	p.N451fs	GAB1_uc003ijd.2_Frame_Shift_Ins_p.N451fs|GAB1_uc011chq.1_Frame_Shift_Ins_p.N348fs	NM_002039	NP_002030	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1 isoform b	451	Pro-rich.				cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(2)|lung(1)|skin(1)	4	all_hematologic(180;0.158)					GTCCCAATGAATCCCAATTCAC	0.351													---	---	---								T	144361303	T	T	144361302	7	5	255	1	0	1	1	0	0	0	0	0	6182	101	4	0	1374	0	GAB1	4	144361302	Frame_Shift_Ins	INS	-	TCGA-CV-7418-01A-11D-2078-08	37195447	144361302	46792974	36	46530											
PRSS48	345062	broad.mit.edu	37	chr4	152201007	152201007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaggatgctgctgcagggCgctggccttggcaggtcagc	5	7	17	12	1	1	0	1	0	0	0	1	1	1	1	2	5	4	5	2	5	0	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr4:152201007C>T	uc011cif.1	+	2	112	c.112C>T	c.(112-114)CGC>TGC	p.R38C	PRSS48_uc011cig.1_Intron	NM_183375	NP_899231	Q7RTY5	PRS48_HUMAN	epidermis-specific serine protease-like protein	38	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			large_intestine(1)	1						TGCTGCAGGGCGCTGGCCTTG	0.527													28	30					0	0	0	0	T	152201007	T	T	152201007	3	4	255	1	0	0	0	0	1	0	0	0	12692	768	27	1	118	1	PRSS48	4	152201007	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	7839705	152201007	38953269	37	46531											
FGA	2243	broad.mit.edu	37	chr4	155510666	155510666	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccacaacccttgggccacGcacgcctcctccttcagcta	7	9	6	19	2	1	0	1	0	0	0	4	0	4	0	6	1	2	2	6	1	2	4	rs121909606		TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr4:155510666G>A	uc003iod.1	-	2	161	c.103C>T	c.(103-105)CGT>TGT	p.R35C	FGA_uc003ioe.1_Missense_Mutation_p.R35C|FGA_uc003iof.1_Missense_Mutation_p.R35C	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	35		Cleavage; by thrombin; to release fibrinopeptide A.	R -> C.|R -> H.		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CTTGGGCCACGCACGCCTCCT	0.493													42	19					0	0	0	0	A	155510666	A	A	155510666	3	1	255	1	0	0	0	0	1	0	0	0	5862	1087	38	1	2561	1	FGA	4	155510666	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	3309659	155510666	35643610	38	46532											
KIAA0947	23379	broad.mit.edu	37	chr5	5461761	5461761	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agccagatttcacatcattaAtaggttctcaggctgccttg	10	13	8	10	0	3	1	3	0	1	1	4	1	3	1	2	2	2	2	2	2	2	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr5:5461761A>G	uc003jdm.3	+	13	2536	c.2314A>G	c.(2314-2316)ATA>GTA	p.I772V		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	772										ovary(1)|central_nervous_system(1)	2						CACATCATTAATAGGTTCTCA	0.388													9	22					0	0	0	0	G	5461761	G	G	5461761	3	3	255	1	0	0	0	0	1	0	0	0	8241	101	4	5	2364	5	KIAA0947	5	5461761	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08		5461761	175453499	39	46533											
APC	324	broad.mit.edu	37	chr5	112173680	112173680	+	Frame_Shift_Del	DEL	G	-	-																															gacacaagcaaagtctctatGgtgattatgtttttgacacc																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr5:112173680delG	uc010jby.2	+	16	2769	c.2389delG	c.(2389-2391)GGTfs	p.G797fs	APC_uc011cvt.1_Frame_Shift_Del_p.G779fs|APC_uc003kpz.3_Frame_Shift_Del_p.G797fs|APC_uc003kpy.3_Frame_Shift_Del_p.G797fs|APC_uc010jbz.2_Frame_Shift_Del_p.G514fs|APC_uc010jca.2_Frame_Shift_Del_p.G97fs	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	797	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AAGTCTCTATGGTGATTATGT	0.358		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			---	---	---								-	112173680	-	-	112173680	7	5	255	1	0	1	0	1	0	0	0	0	763	1348	47	0	2447	0	APC	5	112173680	Frame_Shift_Del	DEL	G	TCGA-CV-7418-01A-11D-2078-08	106711919	112173680	68741580	40	46534											
SLC27A6	28965	broad.mit.edu	37	chr5	128324299	128324299	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttttcttccaggtctacCaaaagcagctgtgattagtc	9	15	7	10	0	3	1	0	1	3	0	5	1	4	1	2	1	3	2	2	1	4	6			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr5:128324299C>T	uc003kuy.2	+	4	1088	c.692C>T	c.(691-693)CCA>CTA	p.P231L	SLC27A6_uc003kuz.2_Missense_Mutation_p.P231L	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	231	AMP (Potential).			P -> S (in Ref. 3; CAG33410).	long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		CCAGGTCTACCAAAAGCAGCT	0.318													30	32					0	0	0	0	T	128324299	T	T	128324299	3	4	255	1	0	0	0	0	1	0	0	0	14594	594	21	4	702	4	SLC27A6	5	128324299	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	16150619	128324299	52590961	41	46535											
WNT8A	7478	broad.mit.edu	37	chr5	137426396	137426396	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagctgagagctgggaacagCgccgagggccactgggtgcc	8	4	17	12	2	0	1	0	1	0	1	0	4	0	2	3	3	5	2	3	3	1	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr5:137426396C>T	uc003lcd.1	+	6	695	c.690C>T	c.(688-690)AGC>AGT	p.S230S	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_Silent_p.S248S|WNT8A_uc011cyk.1_Silent_p.S248S	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	230					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTGGGAACAGCGCCGAGGGCC	0.542													19	28					0	0	0	0	T	137426396	T	T	137426396	2	4	255	1	0	0	0	0	0	0	0	1	17464	767	27	1		1	WNT8A	5	137426396	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	9102097	137426396	43488864	42	46536											
PCDHA2	56146	broad.mit.edu	37	chr5	140175998	140175998	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcagcgtgggatgcggaCgcgcaggagaacgcgctggt	7	6	19	9	6	1	1	1	0	0	1	1	4	1	3	0	4	3	2	0	4	1	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr5:140175998C>A	uc003lhd.2	+	1	1555	c.1449C>A	c.(1447-1449)GAC>GAA	p.D483E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.D483E|PCDHA2_uc011czy.1_Missense_Mutation_p.D483E	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	483	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGATGCGGACGCGCAGGAGA	0.657													38	82					7.05121e-23	8.42904e-23	1	0	A	140175998	A	A	140175998	3	1	255	1	0	0	0	0	1	0	0	0	11578	535	19	3	1451	3	PCDHA2	5	140175998	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	2749602	140175998	40739262	43	46537											
PCDHA3	56145	broad.mit.edu	37	chr5	140182672	140182672	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggggctgtacacgggagaGatcagcacgacccgtgccct	8	6	15	12	3	1	1	1	0	0	1	1	4	1	2	2	3	3	3	2	3	1	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr5:140182672G>T	uc003lhf.2	+	1	1890	c.1890G>T	c.(1888-1890)GAG>GAT	p.E630D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.E630D	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	630	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACGGGAGAGATCAGCACGA	0.657													22	56					2.89027e-11	3.28511e-11	1	0	T	140182672	T	T	140182672	3	4	255	1	0	0	0	0	1	0	0	0	11579	933	33	2	1892	2	PCDHA3	5	140182672	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	6674	140182672	40732588	44	46538											
PCDHGB3	56102	broad.mit.edu	37	chr5	140750142	140750142	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggggtttggcgtgggggatTtacctactaggaacctgcgg	6	11	17	7	2	0	0	0	0	0	0	0	2	0	2	2	7	4	1	2	7	4	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr5:140750142T>G	uc003ljw.1	+	1	181	c.181T>G	c.(181-183)TTA>GTA	p.L61V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Missense_Mutation_p.L61V	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	61	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGGGGATTTACCTACTAG	0.557													6	142					0	0	0	0	G	140750142	G	G	140750142	3	3	255	1	0	0	0	0	1	0	0	0	11618	1838	64	5	183	5	PCDHGB3	5	140750142	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	567470	140750142	40165118	45	46539											
PCDHGB5	56101	broad.mit.edu	37	chr5	140779261	140779261	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgactacgagcagctgcgcAccttcgaactcacactacag	11	8	8	14	3	1	1	1	1	0	0	2	3	1	1	1	0	6	3	1	0	3	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr5:140779261A>T	uc003lkf.1	+	1	1567	c.1567A>T	c.(1567-1569)ACC>TCC	p.T523S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.T523S	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	523	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCTGCGCACCTTCGAACT	0.647													10	24					0	0	0	0	T	140779261	T	T	140779261	3	4	255	1	0	0	0	0	1	0	0	0	11620	159	6	5	1569	5	PCDHGB5	5	140779261	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	29119	140779261	40135999	46	46540											
GLRA1	2741	broad.mit.edu	37	chr5	151202317	151202317	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatgaggaaggccatggggaAgccaatgcgggatattttgt	12	9	15	5	1	0	1	0	1	0	0	0	4	0	4	2	5	2	0	2	5	5	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr5:151202317A>C	uc003lut.2	-	9	1578	c.1291T>G	c.(1291-1293)TTC>GTC	p.F431V	GLRA1_uc003lur.2_Missense_Mutation_p.F423V|GLRA1_uc003lus.2_Missense_Mutation_p.F340V	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	431	Helical; (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GCCATGGGGAAGCCAATGCGG	0.507													26	42					0	0	0	0	C	151202317	C	C	151202317	3	2	255	1	0	0	0	0	1	0	0	0	6491	72	3	5	86	5	GLRA1	5	151202317	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	10423056	151202317	29712943	47	46541											
MICB	4277	broad.mit.edu	37	chr6	31473459	31473459	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatctgtgcagtcagggtttCtcgctgagggacatctggat	7	12	14	8	1	4	1	1	1	3	0	5	4	4	3	0	3	1	3	0	3	0	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr6:31473459C>A	uc003ntn.3	+	2	252	c.136C>A	c.(136-138)CTC>ATC	p.L46I	MICB_uc011dnm.1_Missense_Mutation_p.L14I|MICB_uc003nto.3_Missense_Mutation_p.L46I	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	46	Extracellular (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						GTCAGGGTTTCTCGCTGAGGG	0.562													27	19					2.4375e-19	2.89714e-19	1	0	A	31473459	A	A	31473459	3	1	255	1	0	0	0	0	1	0	0	0	9628	913	32	2	142	2	MICB	6	31473459	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08		31473459	139641608	48	46542											
CYP21A2	1589	broad.mit.edu	37	chr6	31974427	31974427	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccagcccggcacccctgtgGccattgaggaggaattctct	7	8	11	15	1	1	1	0	1	1	0	2	3	1	3	5	4	1	1	5	4	1	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr6:31974427G>A	uc010jtp.2	+	5	596	c.478G>A	c.(478-480)GCC>ACC	p.A160T	CYP21A2_uc011dpb.1_Missense_Mutation_p.A130T			P08686	CP21A_HUMAN	SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2; SubName: Full=Cytochrome P450 21-hydroxylase; SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_b; SubName: Full=DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B)); SubName: Full=cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNA;	159					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						CACCCCTGTGGCCATTGAGGA	0.627													11	11					0	0	0	0	A	31974427	A	A	31974427	3	1	255	1	0	0	0	0	1	0	0	0	4170	1203	42	4	484	4	CYP21A2	6	31974427	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	500968	31974427	139140640	49	46543											
UBR2	23304	broad.mit.edu	37	chr6	42603184	42603184	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccaattacacgtcaagtagGacaacatattgaaatggaac	17	9	7	8	1	1	1	1	1	0	0	2	3	2	3	1	2	3	1	1	2	8	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr6:42603184G>A	uc011dur.1	+	14	1574	c.1574G>A	c.(1573-1575)GGA>GAA	p.G525E	UBR2_uc011dus.1_Missense_Mutation_p.G170E|UBR2_uc010jxv.1_Missense_Mutation_p.G29E|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	525					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			CGTCAAGTAGGACAACATATT	0.348													16	10					0	0	0	0	A	42603184	A	A	42603184	3	1	255	1	0	0	0	0	1	0	0	0	16970	1174	41	2	1774	2	UBR2	6	42603184	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	10628757	42603184	128511883	50	46544											
GPR115	221393	broad.mit.edu	37	chr6	47682615	47682615	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccagagaaaggctacatgaGacctgaggcctgttggctta	11	8	13	9	0	0	3	0	2	0	2	0	5	0	3	3	3	1	3	3	3	3	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr6:47682615G>C	uc003oza.1	+	6	1892	c.1634G>C	c.(1633-1635)AGA>ACA	p.R545T	GPR115_uc003oyz.1_Missense_Mutation_p.R602T|GPR115_uc003ozb.1_Missense_Mutation_p.R543T	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	545	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						GGCTACATGAGACCTGAGGCC	0.483													40	166					0	0	0	0	C	47682615	C	C	47682615	3	2	255	1	0	0	0	0	1	0	0	0	6670	942	33	2	1652	2	GPR115	6	47682615	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	5079431	47682615	123432452	51	46545											
DST	667	broad.mit.edu	37	chr6	56716396	56716396	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcgataggacgcgttccCggaactctacagagaatgac	12	6	12	11	4	1	2	0	1	1	1	2	6	2	4	1	2	3	2	1	2	4	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr6:56716396C>A	uc003pdf.2	-	4	452	c.424G>T	c.(424-426)GGG>TGG	p.G142W	DST_uc011dxj.1_5'UTR|DST_uc011dxk.1_Missense_Mutation_p.G4W|DST_uc011dxl.1_5'UTR	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:Variant_position_missing_in_Q03001_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GACGCGTTCCCGGAACTCTAC	0.502											OREG0017515	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	14					3.86212e-05	4.18396e-05	1	0	A	56716396	A	A	56716396	3	1	255	1	0	0	0	0	1	0	0	0	4805	667	23	3		3	DST	6	56716396	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	9033781	56716396	114398671	52	46546											
COL12A1	1303	broad.mit.edu	37	chr6	75851809	75851809	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatgtactgcagaaacgctGactgtgtacaaggtctgtga	11	11	11	8	1	2	3	1	2	1	1	2	3	2	3	0	1	4	4	0	1	4	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr6:75851809G>A	uc003phs.2	-	27	5062	c.4896C>T	c.(4894-4896)GTC>GTT	p.V1632V	COL12A1_uc003pht.2_Silent_p.V468V	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1632	Fibronectin type-III 11.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CAGAAACGCTGACTGTGTACA	0.493													47	61					0	0	0	0	A	75851809	A	A	75851809	2	1	255	1	0	0	0	0	0	0	0	1	3684	1277	45	2		2	COL12A1	6	75851809	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	19135413	75851809	95263258	53	46547											
LAMA4	3910	broad.mit.edu	37	chr6	112493962	112493962	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacgacaggaaacagagtgcGggtctcattgtgcagccgct	10	7	14	10	3	1	1	1	0	1	1	2	4	1	2	1	2	4	2	1	2	1	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr6:112493962G>C	uc003pvu.2	-	12	1711	c.1402C>G	c.(1402-1404)CGC>GGC	p.R468G	LAMA4_uc003pvv.2_Missense_Mutation_p.R461G|LAMA4_uc003pvt.2_Missense_Mutation_p.R461G	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	468	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		AACAGAGTGCGGGTCTCATTG	0.527													4	29					0	0	0	0	C	112493962	C	C	112493962	3	2	255	1	0	0	0	0	1	0	0	0	8648	1116	39	3	4181	3	LAMA4	6	112493962	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	36642153	112493962	58621105	54	46548											
GJA1	2697	broad.mit.edu	37	chr6	121768632	121768632	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accatcttcatcatcttcatGctggtggtgtccttggtgtc	5	16	9	11	0	5	0	3	0	2	0	7	0	6	0	2	3	1	1	2	3	0	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr6:121768632G>T	uc003pyr.2	+	2	889	c.639G>T	c.(637-639)ATG>ATT	p.M213I	GJA1_uc011ebo.1_Missense_Mutation_p.M114I|GJA1_uc011ebp.1_Missense_Mutation_p.M1I	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	213	Helical; (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	TCATCTTCATGCTGGTGGTGT	0.488													47	78					2.27781e-18	2.69196e-18	1	0	T	121768632	T	T	121768632	3	4	255	1	0	0	0	0	1	0	0	0	6437	1319	46	4	641	4	GJA1	6	121768632	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	9274670	121768632	49346435	55	46549											
ZMIZ2	83637	broad.mit.edu	37	chr7	44801094	44801094	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaccttccctgtgcgcgaTggggtggtcctggagccctt	3	11	14	13	2	0	1	0	1	0	0	2	3	2	2	4	4	2	0	4	4	0	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr7:44801094T>C	uc003tlr.2	+	10	1410	c.1287T>C	c.(1285-1287)GAT>GAC	p.D429D	ZMIZ2_uc003tlq.2_Silent_p.D371D|ZMIZ2_uc003tls.2_Silent_p.D403D|ZMIZ2_uc003tlt.2_Silent_p.D52D|ZMIZ2_uc010kyj.2_5'UTR	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	429					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						CTGTGCGCGATGGGGTGGTCC	0.612													5	80					0	0	0	0	C	44801094	C	C	44801094	2	2	255	1	0	0	0	0	0	0	0	1	17764	1461	51	5		5	ZMIZ2	7	44801094	Silent	SNP	T	TCGA-CV-7418-01A-11D-2078-08		44801094	114337569	56	46550											
ADCY1	107	broad.mit.edu	37	chr7	45697403	45697403	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggtcctctgtggtgtccTgggcttgcgcaagtggcagt	4	11	16	10	1	1	0	0	0	1	0	3	0	3	0	2	4	1	3	2	4	1	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr7:45697403T>A	uc003tne.3	+	6	1244	c.1226T>A	c.(1225-1227)CTG>CAG	p.L409Q	ADCY1_uc003tnd.2_Missense_Mutation_p.L184Q	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	409	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGTGGTGTCCTGGGCTTGCGC	0.602													10	18					0	0	0	0	A	45697403	A	A	45697403	3	1	255	1	0	0	0	0	1	0	0	0	292	1580	55	5	1248	5	ADCY1	7	45697403	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	896309	45697403	113441260	57	46551											
ZNF735	730291	broad.mit.edu	37	chr7	63679786	63679786	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacatatggaaaatgtggAcatgagaatttacaattaaa	20	10	8	3	0	0	2	0	1	0	2	0	5	0	4	0	2	2	0	0	2	9	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr7:63679786A>G	uc011kdn.1	+	4	357	c.357A>G	c.(355-357)GGA>GGG	p.G119G		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAAATGTGGACATGAGAATT	0.348													22	30					0	0	0	0	G	63679786	G	G	63679786	2	3	255	1	0	0	0	0	0	0	0	1	18191	262	10	5		5	ZNF735	7	63679786	Silent	SNP	A	TCGA-CV-7418-01A-11D-2078-08	17982383	63679786	95458877	58	46552											
ACN9	57001	broad.mit.edu	37	chr7	96747113	96747113	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caccgtgttctgcccccggaCctcaaatccctgggcgacca	7	7	9	18	3	2	0	1	0	1	0	3	2	3	1	6	2	1	1	6	2	1	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr7:96747113C>T	uc003uoo.3	+	1	1209	c.78C>T	c.(76-78)GAC>GAT	p.D26D		NM_020186	NP_064571	Q9NRP4	ACN9_HUMAN	ACN9 homolog precursor	26					regulation of gluconeogenesis	mitochondrial intermembrane space					0	all_cancers(62;2.54e-08)|all_epithelial(64;2.24e-08)|Esophageal squamous(72;0.00507)|all_lung(186;0.154)|Lung NSC(181;0.159)					TGCCCCCGGACCTCAAATCCC	0.597													16	58					0	0	0	0	T	96747113	T	T	96747113	2	4	255	1	0	0	0	0	0	0	0	1	145	506	18	4		4	ACN9	7	96747113	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	33067327	96747113	62391550	59	46553											
ZNF394	84124	broad.mit.edu	37	chr7	99091989	99091989	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcactgttctgcaattcattAtttttagagtcttccccttc	7	18	5	11	0	3	1	1	0	2	1	5	1	4	1	2	0	1	3	2	0	3	8			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr7:99091989A>G	uc003uqs.2	-	3	1010	c.849T>C	c.(847-849)AAT>AAC	p.N283N	ZNF394_uc003uqt.2_Silent_p.N76N	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	283					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GCAATTCATTATTTTTAGAGT	0.458													9	103					0	0	0	0	G	99091989	G	G	99091989	2	3	255	1	0	0	0	0	0	0	0	1	17947	446	16	5		5	ZNF394	7	99091989	Silent	SNP	A	TCGA-CV-7418-01A-11D-2078-08	2344876	99091989	60046674	60	46554											
PRKAR2B	5577	broad.mit.edu	37	chr7	106781395	106781395	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacaacttttatgtaattgAtaggtaagttttgcccaacc	12	15	7	7	0	0	2	0	2	0	0	0	2	0	2	2	1	3	3	2	1	6	8			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr7:106781395A>T	uc003vdx.2	+	5	759	c.584A>T	c.(583-585)GAT>GTT	p.D195V		NM_002736	NP_002727	P31323	KAP3_HUMAN	cAMP-dependent protein kinase, regulatory	195	cAMP 1.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1						TATGTAATTGATAGGTAAGTT	0.348													15	28					0	0	0	0	T	106781395	T	T	106781395	3	4	255	1	0	0	0	0	1	0	0	0	12568	333	12	5	602	5	PRKAR2B	7	106781395	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	7689406	106781395	52357268	61	46555											
AHCYL2	23382	broad.mit.edu	37	chr7	129043233	129043233	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	attgcagatcttggatgatgGaggggatcttacccactgga	10	11	13	7	0	2	2	0	1	2	1	2	6	2	6	1	5	2	1	1	5	1	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr7:129043233G>C	uc011kov.1	+	7	986	c.932G>C	c.(931-933)GGA>GCA	p.G311A	AHCYL2_uc003vot.2_Missense_Mutation_p.G310A|AHCYL2_uc003vov.2_Missense_Mutation_p.G208A|AHCYL2_uc011kow.1_Missense_Mutation_p.G209A|AHCYL2_uc011kox.1_Missense_Mutation_p.G208A	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	311					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						TTGGATGATGGAGGGGATCTT	0.403													30	54					0	0	0	0	C	129043233	C	C	129043233	3	2	255	1	0	0	0	0	1	0	0	0	411	1174	41	2	1080	2	AHCYL2	7	129043233	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	22261838	129043233	30095430	62	46556											
PARP12	64761	broad.mit.edu	37	chr7	139727186	139727186	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accttctgatactcttccgaGgaagaactaagggtgatctt	11	12	9	9	1	3	3	0	2	3	1	4	5	4	4	2	2	2	0	2	2	4	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr7:139727186G>T	uc003vvl.1	-	10	2392	c.1518C>A	c.(1516-1518)TCC>TCA	p.S506S	PARP12_uc003vvk.1_Silent_p.S292S|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	506	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					ACTCTTCCGAGGAAGAACTAA	0.448													19	55					2.94398e-08	3.2922e-08	1	0	T	139727186	T	T	139727186	2	4	255	1	0	0	0	0	0	0	0	1	11511	987	35	4		4	PARP12	7	139727186	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	10683953	139727186	19411477	63	46557											
ESCO2	157570	broad.mit.edu	37	chr8	27657230	27657230	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacgactggttgatacccTcaggtaagaaataaaatgga	17	8	10	6	1	1	3	1	1	0	2	1	5	1	4	1	3	1	2	1	3	6	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:27657230T>G	uc003xgg.2	+	10	1753	c.1670T>G	c.(1669-1671)CTC>CGC	p.L557R	ESCO2_uc010luy.1_RNA	NM_001017420	NP_001017420	Q56NI9	ESCO2_HUMAN	establishment of cohesion 1 homolog 2	557					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			central_nervous_system(1)	1		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		GTTGATACCCTCAGGTAAGAA	0.428									SC_Phocomelia_syndrome				26	53					0	0	0	0	G	27657230	G	G	27657230	3	3	255	1	0	0	0	0	1	0	0	0	5273	1551	54	5	1704	5	ESCO2	8	27657230	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08		27657230	118706792	64	46558											
ADAM32	203102	broad.mit.edu	37	chr8	39022614	39022614	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatggtcagatgaaaataaGatttctacagttggtgaggc	13	13	11	4	0	2	4	1	2	1	2	2	4	2	4	0	3	1	1	0	3	5	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:39022614G>T	uc003xmt.3	+	9	977	c.732G>T	c.(730-732)AAG>AAT	p.K244N	ADAM32_uc011lch.1_Missense_Mutation_p.K251N|ADAM32_uc003xmu.3_Missense_Mutation_p.K244N	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	244	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			ATGAAAATAAGATTTCTACAG	0.303													22	32					7.87624e-14	9.10144e-14	1	0	T	39022614	T	T	39022614	3	4	255	1	0	0	0	0	1	0	0	0	249	933	33	2	766	2	ADAM32	8	39022614	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	11365384	39022614	107341408	65	46559											
ZMAT4	79698	broad.mit.edu	37	chr8	40554847	40554847	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgataatgggaatcggccAccaccgctgaagtgaatgac	12	8	11	10	2	0	4	0	4	0	0	1	5	0	5	3	2	0	1	3	2	4	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:40554847A>G	uc003xnr.2	-	4	412	c.266T>C	c.(265-267)GTG>GCG	p.V89A	ZMAT4_uc003xns.2_Missense_Mutation_p.V89A	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	89	Matrin-type 2.					nucleus	DNA binding|zinc ion binding			pancreas(1)|central_nervous_system(1)|skin(1)	3	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			GGAATCGGCCACCACCGCTGA	0.502													23	62					0	0	0	0	G	40554847	G	G	40554847	3	3	255	1	0	0	0	0	1	0	0	0	17761	159	6	5	439	5	ZMAT4	8	40554847	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	1532233	40554847	105809175	66	46560											
SULF1	23213	broad.mit.edu	37	chr8	70517085	70517085	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcaagaatatccaacagtCaaatcacttgcccaaatatg	17	8	5	11	0	2	1	2	0	0	1	3	1	3	1	2	0	3	1	2	0	7	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:70517085C>G	uc010lza.1	+	13	2012	c.1295C>G	c.(1294-1296)TCA>TGA	p.S432*	SULF1_uc003xyd.2_Nonsense_Mutation_p.S432*|SULF1_uc003xye.2_Nonsense_Mutation_p.S432*|SULF1_uc003xyf.2_Nonsense_Mutation_p.S432*|SULF1_uc003xyg.2_Nonsense_Mutation_p.S432*|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	432					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			ATCCAACAGTCAAATCACTTG	0.463													29	49					0	0	0	0	G	70517085	G	G	70517085	4	3	255	1	0	0	0	0	0	1	0	0	15436	838	29	2	1329	2	SULF1	8	70517085	Nonsense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	29962238	70517085	75846937	67	46561											
VPS13B	157680	broad.mit.edu	37	chr8	100880545	100880545	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctggtatagttgatcagccGatgcagaacttccagaaaac	13	9	10	9	1	1	3	1	1	0	2	2	4	2	3	2	1	4	4	2	1	5	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:100880545G>A	uc003yiv.2	+	59	11430	c.11319G>A	c.(11317-11319)CCG>CCA	p.P3773P	VPS13B_uc003yiw.2_Silent_p.P3748P	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3773					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTGATCAGCCGATGCAGAACT	0.493													17	50					0	0	0	0	A	100880545	A	A	100880545	2	1	255	1	0	0	0	0	0	0	0	1	17258	1045	37	1		1	VPS13B	8	100880545	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	30363460	100880545	45483477	68	46562											
DPYS	1807	broad.mit.edu	37	chr8	105459661	105459661	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtcaccatgtacagatctTtataggccataaacatcttg	12	13	6	10	0	3	1	1	0	2	1	3	1	3	1	2	1	2	1	2	1	5	6			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:105459661T>C	uc003yly.3	-	3	623	c.494A>G	c.(493-495)AAA>AGA	p.K165R		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	165					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GTACAGATCTTTATAGGCCAT	0.413													22	70					0	0	0	0	C	105459661	C	C	105459661	3	2	255	1	0	0	0	0	1	0	0	0	4768	1841	64	5	1093	5	DPYS	8	105459661	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	4579116	105459661	40904361	69	46563											
PKHD1L1	93035	broad.mit.edu	37	chr8	110487466	110487466	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtggatcacataaccaacAtttcatatacatcgacattc	14	12	5	10	1	2	0	2	0	0	0	4	2	2	1	1	1	3	0	1	1	4	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:110487466A>G	uc003yne.2	+	51	8829	c.8725A>G	c.(8725-8727)ATT>GTT	p.I2909V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2909	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CATAACCAACATTTCATATAC	0.338										HNSCC(38;0.096)			6	29					0	0	0	0	G	110487466	G	G	110487466	3	3	255	1	0	0	0	0	1	0	0	0	12027	217	8	5	8927	5	PKHD1L1	8	110487466	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	5027805	110487466	35876556	70	46564											
CSMD3	114788	broad.mit.edu	37	chr8	113585824	113585824	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactactaagtgtcagtccGcgcatagatgcaccagtaaa	13	9	9	10	2	1	1	1	0	0	1	2	1	2	1	2	0	3	4	2	0	6	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:113585824G>A	uc003ynu.2	-	24	4107	c.3948C>T	c.(3946-3948)CGC>CGT	p.R1316R	CSMD3_uc003yns.2_Silent_p.R588R|CSMD3_uc003ynt.2_Silent_p.R1276R|CSMD3_uc011lhx.1_Silent_p.R1212R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1316	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTGTCAGTCCGCGCATAGATG	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	88					0	0	0	0	A	113585824	A	A	113585824	2	1	255	1	0	0	0	0	0	0	0	1	3963	1074	38	1		1	CSMD3	8	113585824	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	3098358	113585824	32778198	71	46565											
CSMD3	114788	broad.mit.edu	37	chr8	113988125	113988125	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgttcagcatgtcttggtCttctcctggtactttgtgta	4	19	9	9	0	5	0	1	0	4	0	6	0	5	0	1	2	2	4	1	2	2	6			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:113988125C>G	uc003ynu.2	-	7	1442	c.1283G>C	c.(1282-1284)AGA>ACA	p.R428T	CSMD3_uc003ynt.2_Missense_Mutation_p.R388T|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	428	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATGTCTTGGTCTTCTCCTGGT	0.453										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			36	92					0	0	0	0	G	113988125	G	G	113988125	3	3	255	1	0	0	0	0	1	0	0	0	3963	913	32	2	10100	2	CSMD3	8	113988125	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	402301	113988125	32375897	72	46566											
KIAA0196	9897	broad.mit.edu	37	chr8	126061386	126061386	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaacgatggaatccatccatGgtcgctcccaactctttcag	10	10	8	13	2	2	0	1	0	1	0	6	3	5	1	3	2	2	1	3	2	3	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:126061386G>A	uc003yrt.2	-	19	2570	c.2241C>T	c.(2239-2241)ACC>ACT	p.T747T	KIAA0196_uc011lir.1_Silent_p.T599T|KIAA0196_uc003yru.1_Silent_p.T321T	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	747					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			ATCCATCCATGGTCGCTCCCA	0.403													16	39					0	0	0	0	A	126061386	A	A	126061386	2	1	255	1	0	0	0	0	0	0	0	1	8200	1335	47	4		4	KIAA0196	8	126061386	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	12073261	126061386	20302636	73	46567											
KCNQ3	3786	broad.mit.edu	37	chr8	133141630	133141630	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccgtctcaccctcggcgAggtaccgcttctccctcatc	4	11	8	18	4	3	0	2	0	2	0	8	1	4	0	4	2	1	2	4	2	1	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:133141630A>T	uc003ytj.2	-	15	2723	c.2498T>A	c.(2497-2499)CTC>CAC	p.L833H	KCNQ3_uc010mdt.2_Missense_Mutation_p.L821H|uc003yti.2_5'Flank	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	833					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			ACCCTCGGCGAGGTACCGCTT	0.597													8	34					0	0	0	0	T	133141630	T	T	133141630	3	4	255	1	0	0	0	0	1	0	0	0	8123	304	11	5	124	5	KCNQ3	8	133141630	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	7080244	133141630	13222392	74	46568											
CYC1	1537	broad.mit.edu	37	chr8	145151332	145151332	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaaccataccccaacagTgaggctgctcgagctgccaa	13	5	8	15	1	0	1	0	1	0	0	1	2	0	1	5	1	6	3	5	1	5	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr8:145151332T>C	uc003zaz.3	+	4	589	c.546T>C	c.(544-546)AGT>AGC	p.S182S	CYC1_uc003zay.2_Silent_p.S123S	NM_001916	NP_001907	P08574	CY1_HUMAN	cytochrome c-1	182	Cytochrome c.				respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCCCAACAGTGAGGCTGCTC	0.587											OREG0019052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	56					0	0	0	0	C	145151332	C	C	145151332	2	2	255	1	0	0	0	0	0	0	0	1	4152	1693	59	5		5	CYC1	8	145151332	Silent	SNP	T	TCGA-CV-7418-01A-11D-2078-08	12009702	145151332	1212690	75	46569											
PTPLAD2	401494	broad.mit.edu	37	chr9	21029378	21029378	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattaagtaatagatgaaaaGatacgcattcttcctatacc	16	12	6	7	1	1	3	0	1	1	2	2	4	2	3	2	0	2	2	2	0	8	8			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr9:21029378G>A	uc010miq.1	-	2	104	c.58C>T	c.(58-60)CTT>TTT	p.L20F	PTPLAD2_uc003zoj.1_5'UTR|PTPLAD2_uc010mir.1_Missense_Mutation_p.L20F	NM_001010915	NP_001010915	Q5VWC8	HACD4_HUMAN	protein tyrosine phosphatase-like A domain	20	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	lyase activity			skin(1)	1				Lung(24;6.02e-14)|LUSC - Lung squamous cell carcinoma(38;1.29e-10)		TAGATGAAAAGATACGCATTC	0.328													23	73					0	0	0	0	A	21029378	A	A	21029378	3	1	255	1	0	0	0	0	1	0	0	0	12839	942	33	2	664	2	PTPLAD2	9	21029378	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08		21029378	120184053	76	46570											
KIAA1539	80256	broad.mit.edu	37	chr9	35107864	35107864	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggactccaggcccccgaagtCcaagatgaggtgacactact	11	6	11	13	1	0	3	0	2	0	1	2	5	2	4	4	3	1	0	4	3	3	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr9:35107864C>T	uc003zwl.2	-	3	733	c.408G>A	c.(406-408)TGG>TGA	p.W136*	KIAA1539_uc003zwm.2_Nonsense_Mutation_p.W136*|KIAA1539_uc003zwn.2_Intron|KIAA1539_uc003zwo.2_Nonsense_Mutation_p.W136*|KIAA1539_uc003zwp.1_Nonsense_Mutation_p.W136*|KIAA1539_uc010mkk.1_Intron	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	136						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CCCCCGAAGTCCAAGATGAGG	0.617													16	41					0	0	0	0	T	35107864	T	T	35107864	4	4	255	1	0	0	0	0	0	1	0	0	8281	856	30	2	1236	2	KIAA1539	9	35107864	Nonsense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	14078486	35107864	106105567	77	46571											
PIP5K1B	8395	broad.mit.edu	37	chr9	71532554	71532554	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagagaaagaggaggagaccCcacaaaatgtgcctgatgct	16	5	12	8	0	0	4	0	1	0	3	0	7	0	5	3	2	2	1	3	2	4	0	rs146846422		TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr9:71532554C>T	uc004agu.2	+	9	1167	c.862C>T	c.(862-864)CCA>TCA	p.P288S	PIP5K1B_uc011lrq.1_Missense_Mutation_p.P288S|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	288	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		GGAGGAGACCCCACAAAATGT	0.473													163	56					0	0	0	0	T	71532554	T	T	71532554	3	4	255	1	0	0	0	0	1	0	0	0	11995	623	22	4	884	4	PIP5K1B	9	71532554	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	36424690	71532554	69680877	78	46572											
FAM22G	441457	broad.mit.edu	37	chr9	99694538	99694538	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atggccacaaggggctcatgGagagggcagcctggctccct	8	6	15	12	0	1	1	1	0	0	1	2	2	2	1	3	6	1	3	3	6	1	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr9:99694538G>C	uc004awq.1	+	2	1266	c.551G>C	c.(550-552)GGA>GCA	p.G184A		NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	184										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)				GGGGCTCATGGAGAGGGCAGC	0.647													19	110					0	0	0	0	C	99694538	C	C	99694538	3	2	255	1	0	0	0	0	1	0	0	0	5574	1174	41	2	557	2	FAM22G	9	99694538	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	28161984	99694538	41518893	79	46573											
C5	727	broad.mit.edu	37	chr9	123797114	123797114	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatcttgaagtcaggaaaaGagataattccaatatgatca	18	10	8	5	0	3	3	2	2	1	1	4	6	4	4	1	1	0	0	1	1	7	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr9:123797114G>C	uc004bkv.2	-	5	581	c.551C>G	c.(550-552)TCT>TGT	p.S184C	C5_uc010mvm.1_Missense_Mutation_p.S184C|C5_uc010mvn.1_Missense_Mutation_p.S184C	NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	184					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	GTCAGGAAAAGAGATAATTCC	0.353													12	22					0	0	0	0	C	123797114	C	C	123797114	3	2	255	1	0	0	0	0	1	0	0	0	2290	942	33	2	4627	2	C5	9	123797114	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	24102576	123797114	17416317	80	46574											
CBARA1	10367	broad.mit.edu	37	chr10	74234891	74234891	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcatgctgcagtttacgCtgaaattcgaggaagttttt	11	14	9	7	2	1	1	1	1	0	0	2	3	1	2	0	1	3	5	0	1	3	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr10:74234891C>T	uc001jtb.1	-	9	1039	c.906G>A	c.(904-906)CAG>CAA	p.Q302Q	CBARA1_uc010qjw.1_Silent_p.Q102Q|CBARA1_uc010qjx.1_Silent_p.Q102Q|CBARA1_uc009xqo.1_RNA	NM_006077	NP_006068	Q9BPX6	MICU1_HUMAN	calcium binding atopy-related autoantigen 1	300					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			ovary(1)	1						GCAGTTTACGCTGAAATTCGA	0.468													4	10					0	0	0	0	T	74234891	T	T	74234891	2	4	255	1	0	0	0	0	0	0	0	1	2708	796	28	4		4	CBARA1	10	74234891	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08		74234891	61299856	81	46575											
CC2D2B	387707	broad.mit.edu	37	chr10	97779477	97779477	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtctggtttaatattcaaCaaaataatacaccaatggct	16	12	6	7	0	2	0	1	0	1	0	2	0	2	0	1	3	2	2	1	3	8	6			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr10:97779477C>G	uc001kll.2	+	8	875	c.676C>G	c.(676-678)CAA>GAA	p.Q226E	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_Intron|CC2D2B_uc010qop.1_Missense_Mutation_p.Q226E|uc009xvb.1_RNA	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	226										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		TAATATTCAACAAAATAATAC	0.333													34	126					0	0	0	0	G	97779477	G	G	97779477	3	3	255	1	0	0	0	0	1	0	0	0	2741	479	17	4	702	4	CC2D2B	10	97779477	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	23544586	97779477	37755270	82	46576											
TM9SF3	56889	broad.mit.edu	37	chr10	98292908	98292908	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattgtaccaacaagatttaGaggaagaataacaaaaaaac	22	8	6	5	0	0	3	0	0	0	3	0	4	0	4	1	1	4	1	1	1	11	6			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr10:98292908G>C	uc001kmm.3	-	10	1442	c.1225C>G	c.(1225-1227)CTA>GTA	p.L409V	TM9SF3_uc010qot.1_Missense_Mutation_p.L409V	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	409	Helical; (Potential).					integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		ACAAGATTTAGAGGAAGAATA	0.363													17	31					0	0	0	0	C	98292908	C	C	98292908	3	2	255	1	0	0	0	0	1	0	0	0	16045	933	33	2	568	2	TM9SF3	10	98292908	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	513431	98292908	37241839	83	46577											
C10orf12	26148	broad.mit.edu	37	chr10	98744407	98744407	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcctaaagcagaagttcagaGtaaacgcaagagaacagaag	19	4	11	7	1	1	4	1	0	0	4	1	5	1	4	1	0	3	4	1	0	8	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr10:98744407G>A	uc001kmv.2	+	1	3367	c.3260G>A	c.(3259-3261)AGT>AAT	p.S1087N		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	1087										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GAAGTTCAGAGTAAACGCAAG	0.488													20	24					0	0	0	0	A	98744407	A	A	98744407	3	1	255	1	0	0	0	0	1	0	0	0	1595	1029	36	4	3262	4	C10orf12	10	98744407	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	451499	98744407	36790340	84	46578											
PDCD11	22984	broad.mit.edu	37	chr10	105174033	105174033	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctccttgtcctaggtctatTattgaagctcagtaccttag	8	16	7	10	0	3	1	1	1	2	0	5	1	4	1	3	1	2	2	3	1	6	7			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr10:105174033T>C	uc001kwy.1	+	11	1404	c.1317T>C	c.(1315-1317)ATT>ATC	p.I439I		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	439					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CTAGGTCTATTATTGAAGCTC	0.438													7	19					0	0	0	0	C	105174033	C	C	105174033	2	2	255	1	0	0	0	0	0	0	0	1	11671	1742	61	5		5	PDCD11	10	105174033	Silent	SNP	T	TCGA-CV-7418-01A-11D-2078-08	6429626	105174033	30360714	85	46579											
SORCS3	22986	broad.mit.edu	37	chr10	106982948	106982948	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtcaacatcagtgcagtcGtgtggcccagtcaactgggg	9	8	14	10	1	3	0	3	0	0	0	4	0	3	0	1	4	3	1	1	4	2	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr10:106982948G>A	uc001kyi.1	+	20	3036	c.2809G>A	c.(2809-2811)GTG>ATG	p.V937M	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	937	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAGTGCAGTCGTGTGGCCCAG	0.448													50	53					0	0	0	0	A	106982948	A	A	106982948	3	1	255	1	0	0	0	0	1	0	0	0	14996	1145	40	1	2887	1	SORCS3	10	106982948	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	1808915	106982948	28551799	86	46580											
KIAA1598	57698	broad.mit.edu	37	chr10	118713583	118713583	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctgacactgtactgagaCacaagtctcggcggcaccgt	9	9	10	13	3	2	2	0	2	2	1	3	3	2	2	1	2	1	2	1	2	2	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr10:118713583C>A	uc009xyw.2	-	5	904	c.406G>T	c.(406-408)GTC>TTC	p.V136F	KIAA1598_uc001lcz.3_Missense_Mutation_p.V136F|KIAA1598_uc010qso.1_Missense_Mutation_p.V76F|KIAA1598_uc010qsp.1_Missense_Mutation_p.V136F|KIAA1598_uc010qsq.1_Missense_Mutation_p.V76F|KIAA1598_uc001lcy.3_Missense_Mutation_p.V106F	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	136	Potential.				axon guidance	axon					0				all cancers(201;0.00494)		TGTACTGAGACACAAGTCTCG	0.363													19	26					6.44725e-10	7.2882e-10	1	0	A	118713583	A	A	118713583	3	1	255	1	0	0	0	0	1	0	0	0	8285	478	17	4	1541	4	KIAA1598	10	118713583	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	11730635	118713583	16821164	87	46581											
PDZD8	118987	broad.mit.edu	37	chr10	119044328	119044328	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatcgtctatggcatccAcattttttgcttgcttttca	6	18	6	11	1	2	0	1	0	1	0	4	0	3	0	1	1	3	4	1	1	1	7			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr10:119044328A>G	uc001lde.1	-	5	2115	c.1916T>C	c.(1915-1917)GTG>GCG	p.V639A		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	639					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		TATGGCATCCACATTTTTTGC	0.453													6	55					0	0	0	0	G	119044328	G	G	119044328	3	3	255	1	0	0	0	0	1	0	0	0	11759	159	6	5	1552	5	PDZD8	10	119044328	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	330745	119044328	16490419	88	46582											
ODF3	113746	broad.mit.edu	37	chr11	197593	197593	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acacgcccaccaagctgcgtGcaccggcctacagcttccgt	8	6	9	18	4	0	0	0	0	0	0	1	0	1	0	5	1	5	3	5	1	2	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:197593G>A	uc001lob.2	+	3	436	c.142G>A	c.(142-144)GCA>ACA	p.A48T	ODF3_uc010qvk.1_Missense_Mutation_p.A48T|ODF3_uc001loc.2_Missense_Mutation_p.A48T	NM_053280	NP_444510	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3	48					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm				ovary(1)	1		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CAAGCTGCGTGCACCGGCCTA	0.637													20	23					0	0	0	0	A	197593	A	A	197593	3	1	255	1	0	0	0	0	1	0	0	0	10883	1319	46	4	148	4	ODF3	11	197593	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08		197593	134808923	89	46583											
MUC6	4588	broad.mit.edu	37	chr11	1016769	1016771	+	In_Frame_Del	DEL	GGT	-	-																															tcaccaaggaggtggagaaaGgtggaacgtgagtgggaagt																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:1016769_1016771delGGT	uc001lsw.2	-	31	6081_6083	c.6030_6032delACC	c.(6028-6033)CCACCT>CCT	p.2010_2011PP>P		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	2010_2011	Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGTGGAGAAAGGTGGAACGTGAG	0.537													---	---	---								-	1016771	-	-	1016769	7	5	255	1	0	1	0	1	0	0	0	0	10033	1000	35	0	1299	0	MUC6	11	1016769	In_Frame_Del	DEL	GGT	TCGA-CV-7418-01A-11D-2078-08	819176	1016769	133989747	90	46584											
TNNI2	7136	broad.mit.edu	37	chr11	1862048	1862048	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcccccacacccacccctaGgagctctgcaaacagctgca	10	4	7	20	1	1	0	0	0	1	0	1	1	1	1	5	1	5	4	5	1	2	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:1862048G>A	uc010qxe.1	+	4	209	c.187_splice	c.e4-1	p.E63_splice	TNNI2_uc010qxc.1_Splice_Site_p.E61_splice|TNNI2_uc010qxd.1_Splice_Site_p.E61_splice	NM_001145841	NP_001139313	P48788	TNNI2_HUMAN	fast-twitch skeletal muscle troponin I isoform						muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding				0		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCCACCCCTAGGAGCTCTGCA	0.637													7	10					0	0	0	0	A	1862048	A	A	1862048	5	1	255	1	0	0	0	0	0	0	1	0	16393	1014	35	4	219	4	TNNI2	11	1862048	Splice_Site	SNP	G	TCGA-CV-7418-01A-11D-2078-08	845279	1862048	133144468	91	46585											
KCNJ11	3767	broad.mit.edu	37	chr11	17409554	17409554	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagcgggccctccgctggcGggcacggtacctgggcttgg	5	6	17	13	4	0	0	0	0	0	0	1	0	1	0	3	6	2	4	3	6	2	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:17409554G>A	uc001mna.2	-	1	653	c.85C>T	c.(85-87)CGC>TGC	p.R29C	KCNJ11_uc001mnb.3_Intron	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	29						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		CTCCGCTGGCGGGCACGGTAC	0.652													24	50					0	0	0	0	A	17409554	A	A	17409554	3	1	255	1	0	0	0	0	1	0	0	0	8084	1116	39	1	1091	1	KCNJ11	11	17409554	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	15547506	17409554	117596962	92	46586											
HRASLS2	54979	broad.mit.edu	37	chr11	63325937	63325937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcactggtcagcgaataaGgcaactcctgccccaccaac	11	7	8	15	1	2	0	2	0	0	0	3	1	3	0	4	2	4	1	4	2	4	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:63325937G>A	uc001nxg.1	-	3	373	c.314C>T	c.(313-315)CCT>CTT	p.P105L		NM_017878	NP_060348	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	105					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity				0						CAGCGAATAAGGCAACTCCTG	0.547													12	46					0	0	0	0	A	63325937	A	A	63325937	3	1	255	1	0	0	0	0	1	0	0	0	7389	1000	35	4	182	4	HRASLS2	11	63325937	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	45916383	63325937	71680579	93	46587											
SLC25A45	283130	broad.mit.edu	37	chr11	65144112	65144112	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacccaggaagcaatgccTgcaaagccccctgccaccag	11	3	9	18	0	0	0	0	0	0	0	0	1	0	1	7	1	5	2	7	1	3	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:65144112T>A	uc001odp.1	-	6	1055	c.633A>T	c.(631-633)GCA>GCT	p.A211A	SLC25A45_uc009yqi.1_Silent_p.A149A|SLC25A45_uc001odq.1_Silent_p.A187A|SLC25A45_uc001odr.1_Silent_p.A211A|SLC25A45_uc001ods.1_Silent_p.A169A|SLC25A45_uc001odt.1_Silent_p.A169A	NM_001077241	NP_001070709	Q8N413	S2545_HUMAN	solute carrier family 25, member 45 isoform b	211	Helical; Name=5; (Potential).|Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						AAGCAATGCCTGCAAAGCCCC	0.612													30	19					0	0	0	0	A	65144112	A	A	65144112	2	1	255	1	0	0	0	0	0	0	0	1	14574	1567	55	5		5	SLC25A45	11	65144112	Silent	SNP	T	TCGA-CV-7418-01A-11D-2078-08	1818175	65144112	69862404	94	46588											
CD248	57124	broad.mit.edu	37	chr11	66083244	66083244	+	Missense_Mutation	SNP	C	T	T																															cgggtagggtatctgtggctCtctgtcctctgggaagctcg																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083244C>T	uc001ohm.1	-	1	1272	c.1255G>A	c.(1255-1257)GAG>AAG	p.E419K		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	419	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	ATCTGTGGCTCTCTGTCCTCT	0.657													28	107					0	0	0	0	T	66083244	T	T	66083244	3	4	255	1	0	0	0	0	1	0	0	0	3004	922	32	2	1022	2	CD248	11	66083244	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	939132	66083244	68923272	95	46589	99	2	1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083246	66083246	+	Missense_Mutation	SNP	C	T	T																															ggtagggtatctgtggctctCtgtcctctgggaagctcggt																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083246C>T	uc001ohm.1	-	1	1270	c.1253G>A	c.(1252-1254)AGA>AAA	p.R418K		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	418	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	CTGTGGCTCTCTGTCCTCTGG	0.652													28	107					0	0	0	0	T	66083246	T	T	66083246	3	4	255	1	0	0	0	0	1	0	0	0	3004	913	32	2	1024	2	CD248	11	66083246	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	2	66083246	68923270	96	46590	99	2	1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083267	66083267	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcctctgggaagctcggtCtataggccagggcaaagtca	9	9	13	10	1	3	0	1	0	2	0	5	1	4	1	2	4	1	2	2	4	4	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083267C>G	uc001ohm.1	-	1	1249	c.1232G>C	c.(1231-1233)AGA>ACA	p.R411T		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	411	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	GAAGCTCGGTCTATAGGCCAG	0.647													24	95					0	0	0	0	G	66083267	G	G	66083267	3	3	255	1	0	0	0	0	1	0	0	0	3004	913	32	2	1045	2	CD248	11	66083267	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	21	66083267	68923249	97	46591			1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083379	66083379	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcgtcttcatcttcctcatCctccccgtcatccagcaact	6	13	3	19	2	5	0	3	0	2	0	10	0	9	0	5	0	2	1	5	0	1	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083379C>T	uc001ohm.1	-	1	1137	c.1120G>A	c.(1120-1122)GAT>AAT	p.D374N		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	374	Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	TCTTCCTCATCCTCCCCGTCA	0.622													41	55					0	0	0	0	T	66083379	T	T	66083379	3	4	255	1	0	0	0	0	1	0	0	0	3004	855	30	2	1157	2	CD248	11	66083379	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	112	66083379	68923137	98	46592			1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083463	66083463	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggctgcagctgatgccatCagcctccagctcatgtccct	7	9	10	15	0	2	1	2	1	0	0	4	1	4	1	4	1	5	4	4	1	0	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083463C>G	uc001ohm.1	-	1	1053	c.1036G>C	c.(1036-1038)GAT>CAT	p.D346H		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	346	EGF-like; calcium-binding (Potential).|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	CTGATGCCATCAGCCTCCAGC	0.577													29	33					0	0	0	0	G	66083463	G	G	66083463	3	3	255	1	0	0	0	0	1	0	0	0	3004	826	29	2	1241	2	CD248	11	66083463	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	84	66083463	68923053	99	46593			1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083527	66083527	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaacgtagttgacacacatCtgctggcacacaccggcaat	12	7	8	14	2	1	1	0	1	1	0	1	1	1	1	2	2	2	5	2	2	3	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083527C>T	uc001ohm.1	-	1	989	c.972G>A	c.(970-972)CAG>CAA	p.Q324Q		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	324	EGF-like; calcium-binding (Potential).|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	TGACACACATCTGCTGGCACA	0.602													17	31					0	0	0	0	T	66083527	T	T	66083527	2	4	255	1	0	0	0	0	0	0	0	1	3004	912	32	2		2	CD248	11	66083527	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	64	66083527	68922989	100	46594			1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083548	66083548	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctggcacacaccggcaatCtggcactcatctgtgtccac	8	9	9	15	1	3	0	1	0	2	0	4	0	4	0	2	3	1	4	2	3	1	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083548C>G	uc001ohm.1	-	1	968	c.951G>C	c.(949-951)CAG>CAC	p.Q317H		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	317	EGF-like; calcium-binding (Potential).|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	CACCGGCAATCTGGCACTCAT	0.597													13	29					0	0	0	0	G	66083548	G	G	66083548	3	3	255	1	0	0	0	0	1	0	0	0	3004	912	32	2	1326	2	CD248	11	66083548	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	21	66083548	68922968	101	46595			1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083586	66083586	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacacagcggtgcggatcatCctccgctggccggaaaccca	9	5	11	16	4	1	0	1	0	0	0	3	2	3	2	4	4	3	1	4	4	1	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083586C>A	uc001ohm.1	-	1	930	c.913G>T	c.(913-915)GAT>TAT	p.D305Y		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	305	Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	TGCGGATCATCCTCCGCTGGC	0.617													12	25					1.05317e-09	1.18411e-09	1	0	A	66083586	A	A	66083586	3	1	255	1	0	0	0	0	1	0	0	0	3004	855	30	2	1364	2	CD248	11	66083586	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	38	66083586	68922930	102	46596			1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083748	66083748	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcggcaggacacgtgaccatCcacctcctccacacattcgt	9	7	8	17	3	0	1	0	1	0	0	4	2	3	2	5	2	0	1	5	2	0	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083748C>A	uc001ohm.1	-	1	768	c.751G>T	c.(751-753)GAT>TAT	p.D251Y		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	251	Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	ACGTGACCATCCACCTCCTCC	0.687													27	33					0.000184323	0.000194616	1	0	A	66083748	A	A	66083748	3	1	255	1	0	0	0	0	1	0	0	0	3004	855	30	2	1526	2	CD248	11	66083748	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	162	66083748	68922768	103	46597			1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083845	66083845	+	Silent	SNP	C	T	T																															cgtgaccagcccacacctccCtcaggctgcttcacgcagag																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083845C>T	uc001ohm.1	-	1	671	c.654G>A	c.(652-654)GAG>GAA	p.E218E		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	218	Sushi.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	CCACACCTCCCTCAGGCTGCT	0.662													25	20					0	0	0	0	T	66083845	T	T	66083845	2	4	255	1	0	0	0	0	0	0	0	1	3004	680	24	4		4	CD248	11	66083845	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	97	66083845	68922671	104	46598	100	2	1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083847	66083847	+	Missense_Mutation	SNP	C	T	T																															tgaccagcccacacctccctCaggctgcttcacgcagagca																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083847C>T	uc001ohm.1	-	1	669	c.652G>A	c.(652-654)GAG>AAG	p.E218K		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	218	Sushi.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	ACACCTCCCTCAGGCTGCTTC	0.667													24	20					0	0	0	0	T	66083847	T	T	66083847	3	4	255	1	0	0	0	0	1	0	0	0	3004	835	29	2	1625	2	CD248	11	66083847	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	2	66083847	68922669	105	46599	100	2	1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66083928	66083928	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagccgaagggcagccactCaaactctgtggagaccaggt	12	5	13	11	1	2	2	1	0	1	2	2	4	2	2	3	3	3	1	3	3	2	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66083928C>G	uc001ohm.1	-	1	588	c.571G>C	c.(571-573)GAG>CAG	p.E191Q		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	191	Sushi.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	GGCAGCCACTCAAACTCTGTG	0.677													12	22					0	0	0	0	G	66083928	G	G	66083928	3	3	255	1	0	0	0	0	1	0	0	0	3004	835	29	2	1706	2	CD248	11	66083928	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	81	66083928	68922588	106	46600			1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66084045	66084045	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaactggcacaggtagccgtCgacagccagcgtgcacgagc	11	4	13	13	4	0	0	0	0	0	0	1	2	0	0	2	2	6	3	2	2	2	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66084045C>T	uc001ohm.1	-	1	471	c.454G>A	c.(454-456)GAC>AAC	p.D152N		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	152	C-type lectin.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	AGGTAGCCGTCGACAGCCAGC	0.716													17	15					0	0	0	0	T	66084045	T	T	66084045	3	4	255	1	0	0	0	0	1	0	0	0	3004	884	31	1	1823	1	CD248	11	66084045	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	117	66084045	68922471	107	46601			1	70		14	12	841	N	C	1.340642e-33
CD248	57124	broad.mit.edu	37	chr11	66084084	66084084	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccctccagccagcggtgctCgccacttgcctccagggcca	5	6	11	19	2	0	0	0	0	0	0	3	0	2	0	7	2	4	1	7	2	0	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:66084084C>T	uc001ohm.1	-	1	432	c.415G>A	c.(415-417)GAG>AAG	p.E139K		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	139	C-type lectin.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	CAGCGGTGCTCGCCACTTGCC	0.706													21	17					0	0	0	0	T	66084084	T	T	66084084	3	4	255	1	0	0	0	0	1	0	0	0	3004	893	31	1	1862	1	CD248	11	66084084	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	39	66084084	68922432	108	46602			1	70		14	12	841	N	C	1.340642e-33
TPCN2	219931	broad.mit.edu	37	chr11	68835058	68835058	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcctggtgctgctgaccacgGccaacaaccccgatggtgcg	7	7	12	15	3	0	1	0	1	0	0	1	2	1	1	5	3	5	2	5	3	2	0	rs142288453	byFrequency	TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:68835058G>A	uc001oos.2	+	8	930	c.814G>A	c.(814-816)GCC>ACC	p.A272T	TPCN2_uc009ysk.1_Intron|TPCN2_uc001oor.2_Missense_Mutation_p.A187T|TPCN2_uc010rqg.1_Missense_Mutation_p.A272T	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	272					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCTGACCACGGCCAACAACCC	0.637													12	366					0	0	0	0	A	68835058	A	A	68835058	3	1	255	1	0	0	0	0	1	0	0	0	16463	1203	42	4	844	4	TPCN2	11	68835058	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	2750974	68835058	66171458	109	46603											
KRTAP5-8	57830	broad.mit.edu	37	chr11	71249400	71249400	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgttgctcctcaggctGtgggtcatcctgctgccagt	3	13	12	13	0	2	0	2	0	0	0	4	0	4	0	3	2	4	5	3	2	0	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:71249400G>T	uc001oqr.1	+	1	330	c.299G>T	c.(298-300)TGT>TTT	p.C100F		NM_021046	NP_066384	O75690	KRA58_HUMAN	keratin associated protein 5-8	100	9 X 4 AA repeats of C-C-X-P.					extracellular region|keratin filament	structural constituent of epidermis				0						TCCTCAGGCTGTGGGTCATCC	0.612													72	504					3.79363e-24	4.56113e-24	1	0	T	71249400	T	T	71249400	3	4	255	1	0	0	0	0	1	0	0	0	8607	1377	48	4	301	4	KRTAP5-8	11	71249400	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	2414342	71249400	63757116	110	46604											
TMEM135	65084	broad.mit.edu	37	chr11	87016978	87016978	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttgggttcaatttcagAtgcaaacatggaccaaggca	12	13	9	7	0	2	1	2	0	0	1	2	2	2	2	1	3	2	3	1	3	3	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:87016978A>G	uc001pch.2	+	9	722	c.699A>G	c.(697-699)ATA>ATG	p.I233M	TMEM135_uc010rtt.1_Missense_Mutation_p.I94M|TMEM135_uc001pci.2_Missense_Mutation_p.I211M	NM_022918	NP_075069	Q86UB9	TM135_HUMAN	transmembrane protein 135	233						integral to membrane					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TCAATTTCAGATGCAAACATG	0.284													18	25					0	0	0	0	G	87016978	G	G	87016978	3	3	255	1	0	0	0	0	1	0	0	0	16117	347	12	5	733	5	TMEM135	11	87016978	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	15767578	87016978	47989538	111	46605											
HSPA8	3312	broad.mit.edu	37	chr11	122930647	122930647	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccagctgtagacttgacCtcaaagattccatcctcaat	11	12	5	13	0	3	3	2	1	1	2	6	3	5	3	4	0	1	2	4	0	3	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr11:122930647C>T	uc001pyo.2	-	5	732	c.654G>A	c.(652-654)GAG>GAA	p.E218E	HSPA8_uc009zbc.2_5'UTR|HSPA8_uc001pyp.2_Silent_p.E218E|HSPA8_uc010rzu.1_Silent_p.E141E|HSPA8_uc009zbd.1_Silent_p.E218E|HSPA8_uc010rzv.1_3'UTR	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	218	Interaction with BAG1.				cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TAGACTTGACCTCAAAGATTC	0.453													5	32					0	0	0	0	T	122930647	T	T	122930647	2	4	255	1	0	0	0	0	0	0	0	1	7455	680	24	4		4	HSPA8	11	122930647	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	35913669	122930647	12075869	112	46606											
PARP11	57097	broad.mit.edu	37	chr12	3921420	3921420	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccgtctttggaaggaggtcGcatgtatttggagtctccgt	6	13	13	9	3	2	0	0	0	2	0	4	3	2	3	2	4	0	2	2	4	2	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr12:3921420G>A	uc001qmk.1	-	7	920	c.865C>T	c.(865-867)CGA>TGA	p.R289*	PARP11_uc001qml.2_Nonsense_Mutation_p.R296*|PARP11_uc009zef.2_RNA|PARP11_uc001qmm.2_Nonsense_Mutation_p.R215*|PARP11_uc001qmn.2_Nonsense_Mutation_p.R215*	NM_020367	NP_065100	Q9NR21	PAR11_HUMAN	poly (ADP-ribose) polymerase family, member 11	289	PARP catalytic.						NAD+ ADP-ribosyltransferase activity			ovary(1)|central_nervous_system(1)	2			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)			GAAGGAGGTCGCATGTATTTG	0.413													39	82					0	0	0	0	A	3921420	A	A	3921420	4	1	255	1	0	0	0	0	0	1	0	0	11510	1095	38	1	134	1	PARP11	12	3921420	Nonsense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08		3921420	129930475	113	46607											
C12orf4	57102	broad.mit.edu	37	chr12	4627336	4627336	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccgatgaagtttcacaccActtcgatgatttcttttatg	10	15	7	9	2	2	2	1	2	1	0	3	4	2	2	2	0	1	1	2	0	2	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr12:4627336A>T	uc001qms.2	-	8	1009	c.921T>A	c.(919-921)AGT>AGA	p.S307R	C12orf4_uc001qmt.2_Missense_Mutation_p.S307R	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	307											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		GTTTCACACCACTTCGATGAT	0.413													55	67					0	0	0	0	T	4627336	T	T	4627336	3	4	255	1	0	0	0	0	1	0	0	0	1691	156	6	5	765	5	C12orf4	12	4627336	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	705916	4627336	129224559	114	46608											
COPZ1	22818	broad.mit.edu	37	chr12	54744278	54744278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgctgcagtcagccaaaGaacagatcaagtggtcactc	13	7	11	10	0	3	2	3	0	0	2	4	2	3	2	1	2	4	2	1	2	3	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr12:54744278G>A	uc001sfs.1	+	9	542	c.505G>A	c.(505-507)GAA>AAA	p.E169K	COPZ1_uc001sft.2_Missense_Mutation_p.E118K|COPZ1_uc009znm.1_Missense_Mutation_p.E177K|COPZ1_uc010sot.1_Missense_Mutation_p.E146K	NM_016057	NP_057141	P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	169					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol					0						GTCAGCCAAAGAACAGATCAA	0.493													10	148					0	0	0	0	A	54744278	A	A	54744278	3	1	255	1	0	0	0	0	1	0	0	0	3756	943	33	2	539	2	COPZ1	12	54744278	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	50116942	54744278	79107617	115	46609											
TMEM5	10329	broad.mit.edu	37	chr12	64202512	64202512	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccaagatgccttgcttcaGagtgatctcacattgtgccc	9	12	8	12	0	2	3	2	1	1	2	3	3	2	3	3	0	4	1	3	0	2	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr12:64202512G>C	uc001srq.1	+	6	1076	c.972G>C	c.(970-972)CAG>CAC	p.Q324H	TMEM5_uc001srr.1_Missense_Mutation_p.Q221H|TMEM5_uc001srs.1_Missense_Mutation_p.Q64H	NM_014254	NP_055069	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	324	Extracellular (Potential).					integral to plasma membrane					0		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		CCTTGCTTCAGAGTGATCTCA	0.428													27	60					0	0	0	0	C	64202512	C	C	64202512	3	2	255	1	0	0	0	0	1	0	0	0	16240	933	33	2	994	2	TMEM5	12	64202512	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	9458234	64202512	69649383	116	46610											
ZFC3H1	196441	broad.mit.edu	37	chr12	72057278	72057278	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgctgctgctgctccgaCtccgtatctggctgttatta	4	15	10	12	2	1	0	0	0	1	0	3	1	3	0	2	1	5	8	2	1	3	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr12:72057278C>T	uc001swo.2	-	1	472	c.113G>A	c.(112-114)AGT>AAT	p.S38N	ZFC3H1_uc010sts.1_Missense_Mutation_p.S38N|ZFC3H1_uc001swp.2_Missense_Mutation_p.S38N|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	38	Ser-rich.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GCTGCTCCGACTCCGTATCTG	0.657											OREG0021993	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	60	106					0	0	0	0	T	72057278	T	T	72057278	3	4	255	1	0	0	0	0	1	0	0	0	17700	565	20	4	5996	4	ZFC3H1	12	72057278	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	7854766	72057278	61794617	117	46611											
LHX5	64211	broad.mit.edu	37	chr12	113906037	113906037	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccttgagcgtctccagctgCttggccttgatggtggtgcg	3	12	15	11	2	1	2	0	2	1	0	2	2	1	2	3	3	4	2	3	3	0	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr12:113906037C>T	uc001tvj.1	-	3	1144	c.570G>A	c.(568-570)AAG>AAA	p.K190K		NM_022363	NP_071758	Q9H2C1	LHX5_HUMAN	LIM homeobox protein 5	190	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TCTCCAGCTGCTTGGCCTTGA	0.672													15	24					0	0	0	0	T	113906037	T	T	113906037	2	4	255	1	0	0	0	0	0	0	0	1	8815	796	28	4		4	LHX5	12	113906037	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	41848759	113906037	19945858	118	46612											
FBXO21	23014	broad.mit.edu	37	chr12	117615346	117615346	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaagatacgactcatagtCatctggctgctgaagaaagg	13	10	10	8	1	4	3	3	1	1	2	4	4	4	3	0	2	2	2	0	2	5	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr12:117615346C>T	uc001twk.2	-	4	610	c.571G>A	c.(571-573)GAC>AAC	p.D191N	FBXO21_uc001twj.2_Missense_Mutation_p.D191N|FBXO21_uc009zwq.2_Missense_Mutation_p.D191N	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	191					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		GACTCATAGTCATCTGGCTGC	0.378													47	50					0	0	0	0	T	117615346	T	T	117615346	3	4	255	1	0	0	0	0	1	0	0	0	5765	826	29	2	1351	2	FBXO21	12	117615346	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	3709309	117615346	16236549	119	46613											
KSR2	283455	broad.mit.edu	37	chr12	117968797	117968797	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggggcgcccgggtcggcGtctccggcaccggcaccaca	4	4	15	18	6	1	0	0	0	1	0	3	0	1	0	5	6	0	2	5	6	0	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr12:117968797G>A	uc001two.2	-	12	1719	c.1664C>T	c.(1663-1665)ACG>ATG	p.T555M		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	584					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCGGGTCGGCGTCTCCGGCAC	0.562													51	94					0	0	0	0	A	117968797	A	A	117968797	3	1	255	1	0	0	0	0	1	0	0	0	8622	1145	40	1	1137	1	KSR2	12	117968797	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	353451	117968797	15883098	120	46614											
TPTE2	93492	broad.mit.edu	37	chr13	20138505	20138508	+	5'Flank	DEL	TTTC	-	-																															gtctactaactttttaatgtTttcttcatgctgtgctctca																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr13:20138505_20138508delTTTC	uc010tcm.1	-									Q6XPS3	TPTE2_HUMAN	Homo sapiens mRNA for TPIP alpha lipid phosphatase (TPIP gene).							endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TTTTTAATGTTTTCTTCATGCTGT	0.373													---	---	---								-	20138508	-	-	20138505	6	5	255	0	1	1	0	1	0	0	0	0	16498	1856	64	0		0	TPTE2	13	20138505	5'Flank	DEL	TTTC	TCGA-CV-7418-01A-11D-2078-08		20138505	95031373	121	46615											
HSPH1	10808	broad.mit.edu	37	chr13	31711647	31711647	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgttacaacgggttcacaTgtgttgttcaattcctaaag	10	15	9	7	1	2	0	2	0	0	0	3	0	3	0	1	1	2	4	1	1	5	6			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr13:31711647T>C	uc001utj.2	-	18	2783	c.2385A>G	c.(2383-2385)ACA>ACG	p.T795T	HSPH1_uc001utk.2_Silent_p.T751T|HSPH1_uc010aaw.2_Silent_p.T754T|HSPH1_uc001utl.2_Silent_p.T797T|HSPH1_uc010tds.1_Silent_p.T719T	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	795					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		CGGGTTCACATGTGTTGTTCA	0.358													23	22					0	0	0	0	C	31711647	C	C	31711647	2	2	255	1	0	0	0	0	0	0	0	1	7470	1451	51	5		5	HSPH1	13	31711647	Silent	SNP	T	TCGA-CV-7418-01A-11D-2078-08	11573142	31711647	83458231	122	46616											
MLNR	2862	broad.mit.edu	37	chr13	49796405	49796405	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgcaaggaagtccaggccGagaggcttccacagaagcag	12	4	13	12	2	0	2	0	0	0	2	3	4	2	3	3	3	1	3	3	3	3	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr13:49796405G>A	uc010tgj.1	+	2	1131	c.1131G>A	c.(1129-1131)CCG>CCA	p.P377P		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	377	Cytoplasmic (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		AGTCCAGGCCGAGAGGCTTCC	0.552													29	15					0	0	0	0	A	49796405	A	A	49796405	2	1	255	1	0	0	0	0	0	0	0	1	9685	1045	37	1		1	MLNR	13	49796405	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	18084758	49796405	65373473	123	46617											
TEP1	7011	broad.mit.edu	37	chr14	20837659	20837659	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctgccacatgttacctgtGgtccattctccttctgggct	4	16	8	13	0	3	0	0	0	3	0	5	0	4	0	4	2	2	2	4	2	1	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr14:20837659G>A	uc001vxe.2	-	53	7540	c.7500C>T	c.(7498-7500)ACC>ACT	p.T2500T	TEP1_uc010ahj.1_RNA|TEP1_uc010ahk.2_Silent_p.T1843T|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.T2392T	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2500	WD 19.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TGTTACCTGTGGTCCATTCTC	0.488													5	73					0	0	0	0	A	20837659	A	A	20837659	2	1	255	1	0	0	0	0	0	0	0	1	15825	1335	47	4		4	TEP1	14	20837659	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08		20837659	86511881	124	46618											
JUB	84962	broad.mit.edu	37	chr14	23450641	23450641	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgaagcaaagctgttagctCgtcctggtaccgggcgccca	8	7	13	13	4	0	0	0	0	0	0	2	1	1	0	3	2	4	5	3	2	4	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr14:23450641C>A	uc001whz.2	-	1	1211	c.835G>T	c.(835-837)GAG>TAG	p.E279*		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	279	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		GCTGTTAGCTCGTCCTGGTAC	0.711													7	15					8.12818e-05	8.71475e-05	1	0	A	23450641	A	A	23450641	4	1	255	1	0	0	0	0	0	1	0	0	8007	893	31	3	813	3	JUB	14	23450641	Nonsense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	2612982	23450641	83898899	125	46619											
PSMB5	5693	broad.mit.edu	37	chr14	23502633	23502633	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatggacagccccatgcctTtgtactgatacaccatgttg	9	11	8	13	0	0	1	0	1	0	0	0	2	0	2	5	1	4	2	5	1	2	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr14:23502633T>C	uc001wii.2	-	2	713	c.449A>G	c.(448-450)AAA>AGA	p.K150R	PSMB5_uc001wij.2_Missense_Mutation_p.K150R|PSMB5_uc010tni.1_Missense_Mutation_p.K47R	NM_002797	NP_002788	P28074	PSB5_HUMAN	proteasome beta 5 subunit isoform 1	150					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus	protein binding|threonine-type endopeptidase activity			ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0121)	Bortezomib(DB00188)	CCCCATGCCTTTGTACTGATA	0.517													33	69					0	0	0	0	C	23502633	C	C	23502633	3	2	255	1	0	0	0	0	1	0	0	0	12742	1841	64	5	439	5	PSMB5	14	23502633	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	51992	23502633	83846907	126	46620											
ACIN1	22985	broad.mit.edu	37	chr14	23535181	23535181	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggggctggacttacagacaaCggagatcttcctcttgaatg	10	10	12	9	1	2	3	0	1	2	2	3	5	3	4	1	4	2	1	1	4	3	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr14:23535181C>T	uc001wit.3	-	10	2804	c.2476G>A	c.(2476-2478)GTT>ATT	p.V826I	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.V68I|ACIN1_uc001wiq.3_Missense_Mutation_p.V68I|ACIN1_uc001wir.3_Missense_Mutation_p.V99I|ACIN1_uc001wis.3_Missense_Mutation_p.V508I|ACIN1_uc010akg.2_Missense_Mutation_p.V826I	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	826					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TTACAGACAACGGAGATCTTC	0.433													15	39					0	0	0	0	T	23535181	T	T	23535181	3	4	255	1	0	0	0	0	1	0	0	0	142	536	19	1	1589	1	ACIN1	14	23535181	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	32548	23535181	83814359	127	46621											
HECTD1	25831	broad.mit.edu	37	chr14	31626071	31626071	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggttttgattcctcttcaTtctcatcatcagaggaagga	9	15	8	9	0	5	2	4	1	2	1	7	4	6	4	1	3	0	1	1	3	1	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr14:31626071T>G	uc001wrc.1	-	12	2396	c.1907A>C	c.(1906-1908)AAT>ACT	p.N636T	HECTD1_uc001wrd.1_Missense_Mutation_p.N151T	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	636					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TTCCTCTTCATTCTCATCATC	0.343													25	36					0	0	0	0	G	31626071	G	G	31626071	3	3	255	1	0	0	0	0	1	0	0	0	7078	1493	52	5	6053	5	HECTD1	14	31626071	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	8090890	31626071	75723469	128	46622											
C14orf104	55172	broad.mit.edu	37	chr14	50100984	50100985	+	Missense_Mutation	DNP	GC	TT	TT																															cctccagcgccgcctgctcgGccgagcgcaacagcggcagt																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr14:50100984_50100985GC>TT	uc001wws.3	-	1	964_965	c.883_884GC>AA	c.(883-885)GCC>AAC	p.A295N	SDCCAG1_uc010anj.1_Intron|C14orf104_uc001wwt.3_Missense_Mutation_p.A295N	NM_018139	NP_060609	Q9NVR5	KTU_HUMAN	kintoun isoform 1	295					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm					0	all_epithelial(31;0.0021)|Breast(41;0.0124)					CGCCTGCTCGGCCGAGCGCAAC	0.653									Kartagener_syndrome				10	26					0	0	0	0	TT	50100985	TT	TT	50100984	3	4	255	1	0	0	0	0	1	0	0	0	1742	1203	42	4	1641	4	C14orf104	14	50100984	Missense_Mutation	DNP	GC	TCGA-CV-7418-01A-11D-2078-08	18474913	50100984	57248556	129	46623											
SLC35F4	341880	broad.mit.edu	37	chr14	58036671	58036671	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagcttccccaaagttggCacttccaagaaacattttaa	13	11	6	11	0	0	1	0	0	0	1	2	1	2	1	3	1	3	4	3	1	4	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr14:58036671C>A	uc001xdb.1	-	6	1069	c.1069G>T	c.(1069-1071)GCC>TCC	p.A357S	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.A198S	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						CCAAAGTTGGCACTTCCAAGA	0.428													9	12					0.00829132	0.00853759	1	0	A	58036671	A	A	58036671	3	1	255	1	0	0	0	0	1	0	0	0	14655	710	25	4	508	4	SLC35F4	14	58036671	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	7935687	58036671	49312869	130	46624											
SIX4	51804	broad.mit.edu	37	chr14	61180764	61180764	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctcctttccaagccttcCtgtttcacagatcctatagt	8	14	6	13	0	1	1	1	0	0	1	5	1	5	1	5	1	1	2	5	1	3	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr14:61180764C>T	uc001xfc.2	-	3	1707	c.1707G>A	c.(1705-1707)CAG>CAA	p.Q569Q		NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	sine oculis homeobox homolog 4	569						nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		CCAAGCCTTCCTGTTTCACAG	0.468													13	19					0	0	0	0	T	61180764	T	T	61180764	2	4	255	1	0	0	0	0	0	0	0	1	14414	680	24	4		4	SIX4	14	61180764	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	3144093	61180764	46168776	131	46625											
EXD2	55218	broad.mit.edu	37	chr14	69704290	69704290	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccggctgggcttgttccAggaagaacgtgattccacat	8	12	11	10	2	0	2	0	1	0	1	3	3	3	3	3	3	1	3	3	3	2	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr14:69704290A>G	uc001xkt.2	+	10	1577	c.918_splice	c.e10-2	p.R306_splice	EXD2_uc001xku.2_Splice_Site_p.R176_splice|EXD2_uc001xkv.2_Splice_Site_p.R431_splice|EXD2_uc001xkw.2_Splice_Site_p.R306_splice|EXD2_uc010aqt.2_Splice_Site_p.R431_splice|EXD2_uc010tte.1_Splice_Site_p.R431_splice|EXD2_uc001xky.2_Splice_Site_p.R306_splice	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						GGCTTGTTCCAGGAAGAACGT	0.552													14	23					0	0	0	0	G	69704290	G	G	69704290	5	3	255	1	0	0	0	0	0	0	1	0	5322	202	7	5	938	5	EXD2	14	69704290	Splice_Site	SNP	A	TCGA-CV-7418-01A-11D-2078-08	8523526	69704290	37645250	132	46626											
SEL1L	6400	broad.mit.edu	37	chr14	81965994	81965995	+	Missense_Mutation	DNP	GA	TT	TT																															accaagtccagaggcatacaGaaagccaagagcctgaaata																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr14:81965994_81965995GA>TT	uc010tvv.1	-	7	906_907	c.789_790TC>AA	c.(787-792)TTTCTG>TTAATG	p.263_264FL>LM	SEL1L_uc001xvo.3_Missense_Mutation_p.263_264FL>LM	NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	263_264	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Sel1-like 3.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		GAGGCATACAGAAAGCCAAGAG	0.337													8	34					0	0	0	0	TT	81965995	TT	TT	81965994	3	4	255	1	0	0	0	0	1	0	0	0	14075	933	33	2	1654	2	SEL1L	14	81965994	Missense_Mutation	DNP	GA	TCGA-CV-7418-01A-11D-2078-08	12261704	81965994	25383546	133	46627											
C15orf2	23742	broad.mit.edu	37	chr15	24921325	24921325	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acccatgctgcctgctcggaAccccccgaggtttggacacc	7	7	10	17	2	0	0	0	0	0	0	1	3	0	2	6	3	4	3	6	3	1	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr15:24921325A>C	uc001ywo.2	+	1	785	c.311A>C	c.(310-312)AAC>ACC	p.N104T		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	104					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTGCTCGGAACCCCCCGAGG	0.682													4	49					0	0	0	0	C	24921325	C	C	24921325	3	2	255	1	0	0	0	0	1	0	0	0	1790	43	2	5	313	5	C15orf2	15	24921325	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08		24921325	77610067	134	46628											
HERC2	8924	broad.mit.edu	37	chr15	28389228	28389228	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatggtggcatttacctaggGcactcagctgtgcacaagct	10	10	11	10	0	1	0	1	0	0	0	1	0	1	0	1	3	4	5	1	3	4	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr15:28389228G>A	uc001zbj.2	-	73	11400	c.11294C>T	c.(11293-11295)GCC>GTC	p.A3765V		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3765					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTTACCTAGGGCACTCAGCTG	0.507													30	64					0	0	0	0	A	28389228	A	A	28389228	3	1	255	1	0	0	0	0	1	0	0	0	7097	1203	42	4	3294	4	HERC2	15	28389228	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	3467903	28389228	74142164	135	46629											
TTBK2	146057	broad.mit.edu	37	chr15	43102902	43102902	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgtttcaacatgagcctGtggtcatatctctccttaat	10	15	7	9	0	3	2	2	1	1	1	5	2	4	2	2	1	2	1	2	1	3	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr15:43102902G>A	uc001zqo.2	-	9	1171	c.732C>T	c.(730-732)CAC>CAT	p.H244H	TTBK2_uc010bcy.2_Silent_p.H175H|TTBK2_uc001zqp.2_Silent_p.H244H|TTBK2_uc010bcz.1_Silent_p.H209H	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	244	Protein kinase.				cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		ACATGAGCCTGTGGTCATATC	0.413													31	52					0	0	0	0	A	43102902	A	A	43102902	2	1	255	1	0	0	0	0	0	0	0	1	16745	1368	48	4		4	TTBK2	15	43102902	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	14713674	43102902	59428490	136	46630											
TGM7	116179	broad.mit.edu	37	chr15	43579612	43579612	+	Frame_Shift_Del	DEL	C	-	-																															cccctttggagtagtcctcgCcccagttcccctgcagcacg																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr15:43579612delC	uc001zrf.1	-	6	736	c.731delG	c.(730-732)GGCfs	p.G244fs		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	244					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GTAGTCCTCGCCCCAGTTCCC	0.607													---	---	---								-	43579612	-	-	43579612	7	5	255	1	0	1	0	1	0	0	0	0	15901	739	26	0	1433	0	TGM7	15	43579612	Frame_Shift_Del	DEL	C	TCGA-CV-7418-01A-11D-2078-08	476710	43579612	58951780	137	46631											
SLC30A4	7782	broad.mit.edu	37	chr15	45814465	45814465	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccgcctcatccgagaagtCaaaggcgctggtgtcattta	9	9	10	13	3	3	1	3	0	0	1	4	2	4	1	4	2	0	1	4	2	3	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr15:45814465C>G	uc001zvj.2	-	2	400	c.88G>C	c.(88-90)GAC>CAC	p.D30H	C15orf21_uc010beg.1_Intron|C15orf21_uc010beh.1_Intron|C15orf21_uc010bei.1_Intron|C15orf21_uc010bej.1_Intron|C15orf21_uc001zvm.1_Intron|C15orf21_uc001zvn.1_Intron	NM_013309	NP_037441	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter),	30	Cytoplasmic (Potential).|Asp-rich (acidic).			D -> E (in Ref. 1; AAB82561).	regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity				0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)		TCCGAGAAGTCAAAGGCGCTG	0.572													23	33					0	0	0	0	G	45814465	G	G	45814465	3	3	255	1	0	0	0	0	1	0	0	0	14621	826	29	2	1229	2	SLC30A4	15	45814465	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	2234853	45814465	56716927	138	46632											
ADPGK	83440	broad.mit.edu	37	chr15	73044806	73044806	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtggaaggatattccctctCtgtgccattctactactggc	8	13	9	11	0	2	0	0	0	2	0	4	2	3	2	2	3	3	0	2	3	4	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr15:73044806C>G	uc002avg.3	-	7	1464	c.1370G>C	c.(1369-1371)AGA>ACA	p.R457T	ADPGK_uc002ave.3_Missense_Mutation_p.R182T|ADPGK_uc010ukw.1_Missense_Mutation_p.R399T|ADPGK_uc002avf.3_Missense_Mutation_p.R456T|ADPGK_uc002avi.3_Missense_Mutation_p.R334T|ADPGK_uc002avh.3_Missense_Mutation_p.R218T	NM_031284	NP_112574	Q9BRR6	ADPGK_HUMAN	ADP-dependent glucokinase	457	ADPK.				glycolysis	extracellular region	ADP-specific glucokinase activity|metal ion binding				0						TATTCCCTCTCTGTGCCATTC	0.493													41	116					0	0	0	0	G	73044806	G	G	73044806	3	3	255	1	0	0	0	0	1	0	0	0	330	913	32	2	127	2	ADPGK	15	73044806	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	27230341	73044806	29486586	139	46633											
SNX33	257364	broad.mit.edu	37	chr15	75942185	75942185	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccaaattcaagggcatcaaaAgctacatctcctacaagctc	15	8	5	13	0	3	0	2	0	1	0	5	0	3	0	2	1	4	3	2	1	7	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr15:75942185A>G	uc002bau.2	+	1	838	c.742A>G	c.(742-744)AGC>GGC	p.S248G	IMP3_uc002bat.2_5'Flank|SNX33_uc002bav.2_5'UTR	NM_153271	NP_695003	Q8WV41	SNX33_HUMAN	sorting nexin 33	248	PX.				cell communication		phosphatidylinositol binding|protein binding			ovary(1)	1						GGGCATCAAAAGCTACATCTC	0.547													12	212					0	0	0	0	G	75942185	G	G	75942185	3	3	255	1	0	0	0	0	1	0	0	0	14967	72	3	5	744	5	SNX33	15	75942185	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	2897379	75942185	26589207	140	46634											
CHRNB4	1143	broad.mit.edu	37	chr15	78923490	78923490	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggatgttcacaccctcgtagCgggagctgttccaggtcagg	7	9	14	11	2	2	0	2	0	0	0	4	2	3	2	2	4	2	4	2	4	1	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr15:78923490C>T	uc002bed.1	-	4	399	c.287G>A	c.(286-288)CGC>CAC	p.R96H	CHRNB4_uc002bee.1_Missense_Mutation_p.R96H|CHRNB4_uc010blh.1_5'UTR	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	96	Extracellular (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						ACCCTCGTAGCGGGAGCTGTT	0.577													27	72					0	0	0	0	T	78923490	T	T	78923490	3	4	255	1	0	0	0	0	1	0	0	0	3408	768	27	1	1221	1	CHRNB4	15	78923490	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	2981305	78923490	23607902	141	46635											
HAPLN3	145864	broad.mit.edu	37	chr15	89424690	89424691	+	Frame_Shift_Del	DEL	GC	-	-																															ccgcagatcctggatctccaGcgagacgtcatgctctttgt																								rs78894646	byFrequency	TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr15:89424690_89424691delGC	uc002bnc.2	-	3	518_519	c.390_391delGC	c.(388-393)TCGCTGfs	p.S130fs	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Frame_Shift_Del_p.S192fs	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	130_131	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					TGGATCTCCAGCGAGACGTCAT	0.629													---	---	---								-	89424691	-	-	89424690	7	5	255	1	0	1	0	1	0	0	0	0	6995	962	34	0	703	0	HAPLN3	15	89424690	Frame_Shift_Del	DEL	GC	TCGA-CV-7418-01A-11D-2078-08	10501200	89424690	13106702	142	46636											
POLG	5428	broad.mit.edu	37	chr15	89876485	89876485	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctccgcccaggcccaagcCgggggcttcgggggcagctg	4	4	16	17	3	0	0	0	0	0	0	2	0	1	0	5	5	2	3	5	5	1	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-11A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	269e1950-5b9e-4b06-9dbe-d809e280243b	g.chr15:89876485C>T	uc002bns.3	-	2	783	c.501G>A	c.(499-501)CCG>CCA	p.P167P	POLG_uc002bnr.3_Silent_p.P167P	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	167					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			AGGCCCAAGCCGGGGGCTTCG	0.726								DNA_polymerases_(catalytic_subunits)					8	15					0	0	0	0	T	89876485	T	T	89876485	2	4	255	1	0	0	0	0	0	0	0	1	12255	639	23	1		1	POLG	15	89876485	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	451795	89876485	12654907	143	46637											
KIAA0556	23247	broad.mit.edu	37	chr16	27765493	27765493	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttctccaacccatgtgcaGatcccggagctagagctccc	8	8	9	16	1	1	2	0	0	1	2	4	3	3	3	4	1	4	4	4	1	2	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr16:27765493G>A	uc002dow.2	+	18	3577	c.3553_splice	c.e18-1	p.I1185_splice		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247											ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						CCCATGTGCAGATCCCGGAGC	0.562													31	30					0	0	0	0	A	27765493	A	A	27765493	5	1	255	1	0	0	0	0	0	0	1	0	8222	956	33	2	3622	2	KIAA0556	16	27765493	Splice_Site	SNP	G	TCGA-CV-7418-01A-11D-2078-08		27765493	62589260	144	46638											
CES2	8824	broad.mit.edu	37	chr16	66975087	66975087	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggccctggtgggctgcctgCggggcaagagtaaagaggag	9	5	19	8	1	0	2	0	0	0	2	0	3	0	3	2	6	2	3	2	6	3	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr16:66975087C>T	uc002eqr.2	+	6	2069	c.1069C>T	c.(1069-1071)CGG>TGG	p.R357W	CES2_uc002eqq.2_Missense_Mutation_p.R357W|CES2_uc002eqs.2_Missense_Mutation_p.R200W	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	293					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		GGGCTGCCTGCGGGGCAAGAG	0.572													3	43					0	0	0	0	T	66975087	T	T	66975087	3	4	255	1	0	0	0	0	1	0	0	0	3285	759	27	1	1091	1	CES2	16	66975087	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	39209594	66975087	23379666	145	46639											
ELMO3	79767	broad.mit.edu	37	chr16	67234109	67234109	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgccaggaccttgaggctgaGcagctcttgggtgggctgca	6	9	16	10	0	1	2	0	2	1	0	1	3	1	3	2	4	4	5	2	4	0	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr16:67234109G>A	uc002esa.2	+	5	460	c.417G>A	c.(415-417)GAG>GAA	p.E139E	ELMO3_uc002esb.2_Silent_p.E122E|ELMO3_uc002esc.2_5'UTR	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	86					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		TTGAGGCTGAGCAGCTCTTGG	0.642													7	7					0	0	0	0	A	67234109	A	A	67234109	2	1	255	1	0	0	0	0	0	0	0	1	5091	962	34	4		4	ELMO3	16	67234109	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	259022	67234109	23120644	146	46640											
MNT	4335	broad.mit.edu	37	chr17	2290453	2290453	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggtgggccacatggttgagGgtggcagggtgcacagtgat	8	8	19	6	0	0	2	0	2	0	0	0	2	0	2	1	6	1	3	1	6	0	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:2290453G>C	uc002fur.2	-	6	1743	c.1491C>G	c.(1489-1491)ACC>ACG	p.T497T		NM_020310	NP_064706	Q99583	MNT_HUMAN	MAX binding protein	497					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			skin(1)	1				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		CATGGTTGAGGGTGGCAGGGT	0.682													7	5					0	0	0	0	C	2290453	C	C	2290453	2	2	255	1	0	0	0	0	0	0	0	1	9731	1219	43	4		4	MNT	17	2290453	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08		2290453	78904757	147	46641											
ANKFY1	51479	broad.mit.edu	37	chr17	4098291	4098291	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctgtcgccgtgtcaggtgCgtctgtgtggctgccgcgct	2	11	15	13	5	2	0	1	0	1	0	3	0	2	0	3	2	2	2	3	2	0	0	rs147745463	by1000genomes	TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:4098291C>T	uc002fxq.1	-	10	1392	c.1354G>A	c.(1354-1356)GCA>ACA	p.A452T	ANKFY1_uc002fxn.2_Missense_Mutation_p.A494T|ANKFY1_uc002fxo.2_Missense_Mutation_p.A452T|ANKFY1_uc002fxp.2_Missense_Mutation_p.A451T|ANKFY1_uc010ckp.2_Missense_Mutation_p.A393T|ANKFY1_uc002fxr.2_Missense_Mutation_p.A452T	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	452						endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3						GTGTCAGGTGCGTCTGTGTGG	0.572													14	31					0	0	0	0	T	4098291	T	T	4098291	3	4	255	1	0	0	0	0	1	0	0	0	626	768	27	1	2314	1	ANKFY1	17	4098291	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	1807838	4098291	77096919	148	46642											
TP53	7157	broad.mit.edu	37	chr17	7577534	7577534	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgatgatggtgaggatgggCctccggttcatgccgcccat	6	10	15	10	2	1	3	1	3	0	0	2	4	2	4	4	4	1	1	4	4	0	1	rs28934571		TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:7577534C>A	uc002gim.2	-	7	941	c.747G>T	c.(745-747)AGG>AGT	p.R249S	TP53_uc002gig.1_Missense_Mutation_p.R249S|TP53_uc002gih.2_Missense_Mutation_p.R249S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R117S|TP53_uc010cng.1_Missense_Mutation_p.R117S|TP53_uc002gii.1_Missense_Mutation_p.R117S|TP53_uc010cnh.1_Missense_Mutation_p.R249S|TP53_uc010cni.1_Missense_Mutation_p.R249S|TP53_uc002gij.2_Missense_Mutation_p.R249S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R156S|TP53_uc002gio.2_Missense_Mutation_p.R117S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	249	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> I (in a sporadic cancer; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249S(303)|p.R249M(25)|p.R249G(24)|p.R249W(23)|p.R249T(16)|p.R249K(14)|p.0?(7)|p.R249R(6)|p.R249fs*96(6)|p.M246_P250delMNRRP(2)|p.R249fs*14(2)|p.N247_P250delNRRP(1)|p.R249fs*19(1)|p.R249fs*15(1)|p.R249_I251delRPI(1)|p.R249_P250delRP(1)|p.R249_P250insR(1)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.R249_T256delRPILTIIT(1)|p.R249_P250>SS(1)|p.P250fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGAGGATGGGCCTCCGGTTCA	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			38	19					7.63091e-17	8.9674e-17	1	0	A	7577534	A	A	7577534	3	1	255	1	0	0	0	0	1	0	0	0	16448	738	26	4	543	4	TP53	17	7577534	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	3479243	7577534	73617676	149	46643											
MYH10	4628	broad.mit.edu	37	chr17	8383589	8383589	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcgtgcattgtcactcttCtgggcggcgctgcgctcggc	2	11	15	13	5	3	0	1	0	2	0	4	0	3	0	0	4	2	3	0	4	0	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:8383589C>A	uc002gll.2	-	38	5439	c.5343G>T	c.(5341-5343)CAG>CAT	p.Q1781H	MYH10_uc002glm.2_Missense_Mutation_p.Q1812H|MYH10_uc010cnx.2_Missense_Mutation_p.Q1790H	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1781	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TGTCACTCTTCTGGGCGGCGC	0.592													33	71					1.57351e-24	1.90285e-24	1	0	A	8383589	A	A	8383589	3	1	255	1	0	0	0	0	1	0	0	0	10083	912	32	2	603	2	MYH10	17	8383589	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	806055	8383589	72811621	150	46644											
FLCN	201163	broad.mit.edu	37	chr17	17120410	17120410	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttcaaaagctgactggacGaggtccacgtctctgctttt	9	12	9	11	2	2	1	1	1	1	0	4	3	3	2	1	2	2	2	1	2	2	3	rs150752548		TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:17120410G>A	uc002gra.3	-	10	1653	c.1149C>T	c.(1147-1149)CTC>CTT	p.L383L	PLD6_uc010cpn.2_RNA	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	383					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						CTGACTGGACGAGGTCCACGT	0.567									Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				12	29					0	0	0	0	A	17120410	A	A	17120410	2	1	255	1	0	0	0	0	0	0	0	1	5953	1045	37	1		1	FLCN	17	17120410	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	8736821	17120410	64074800	151	46645											
PIGS	94005	broad.mit.edu	37	chr17	26882020	26882020	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtcattagcccttcactcGtaggccctgaaagcaggcat	10	9	10	12	1	2	1	2	1	0	0	3	1	2	1	2	3	2	3	2	3	3	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:26882020G>C	uc002hbo.2	-	11	1614	c.1241C>G	c.(1240-1242)ACG>AGG	p.T414R	UNC119_uc002hbk.2_5'Flank|UNC119_uc002hbm.2_5'Flank|PIGS_uc002hbn.2_Missense_Mutation_p.T406R|PIGS_uc010wap.1_Missense_Mutation_p.T353R	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	414	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					CCCTTCACTCGTAGGCCCTGA	0.592													18	25					0	0	0	0	C	26882020	C	C	26882020	3	2	255	1	0	0	0	0	1	0	0	0	11953	1145	40	3	434	3	PIGS	17	26882020	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	9761610	26882020	54313190	152	46646											
SLC6A4	6532	broad.mit.edu	37	chr17	28537590	28537590	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atgaccacggcgagcacgaaCcgctcccggcgcttggccca	8	4	12	17	6	0	1	0	1	0	0	1	3	1	1	4	3	2	3	4	3	1	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:28537590C>T	uc002hey.3	-	11	1936	c.1392G>A	c.(1390-1392)CGG>CGA	p.R464R	SLC6A4_uc010csg.2_RNA	NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	464	Helical; Name=9; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CGAGCACGAACCGCTCCCGGC	0.597													12	48					0	0	0	0	T	28537590	T	T	28537590	2	4	255	1	0	0	0	0	0	0	0	1	14750	494	18	4		4	SLC6A4	17	28537590	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	1655570	28537590	52657620	153	46647											
SYNRG	11276	broad.mit.edu	37	chr17	35896099	35896100	+	Frame_Shift_Ins	INS	-	A	A																															ctgtgagtgtggcgagtgacINSatgaagccgattaggttatt																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:35896099_35896100insA	uc002hoa.2	-	19	3730_3731	c.3647_3648insT	c.(3646-3648)ATGfs	p.M1216fs	SYNRG_uc010wde.1_Frame_Shift_Ins_p.M1138fs|SYNRG_uc010wdf.1_Frame_Shift_Ins_p.M1138fs|SYNRG_uc002hoc.2_Frame_Shift_Ins_p.M1137fs|SYNRG_uc002hoe.2_Frame_Shift_Ins_p.M1138fs|SYNRG_uc002hod.2_Frame_Shift_Ins_p.M1093fs|SYNRG_uc010wdg.1_Frame_Shift_Ins_p.M1010fs|SYNRG_uc002hob.2_Frame_Shift_Ins_p.M1216fs	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	1216					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						TGGCGAGTGACATGAAGCCGAT	0.46													---	---	---								A	35896100	A	A	35896099	7	5	255	1	0	1	1	0	0	0	0	0	15526	478	17	0	385	0	SYNRG	17	35896099	Frame_Shift_Ins	INS	-	TCGA-CV-7418-01A-11D-2078-08	7358509	35896099	45299111	154	46648											
CACNB1	782	broad.mit.edu	37	chr17	37347836	37347836	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggacggctggtgtaggacTccgctgagccctgaaaatag	10	8	14	9	2	0	2	0	2	0	0	1	4	1	4	2	4	1	3	2	4	4	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:37347836T>C	uc002hrm.1	-	3	335	c.182A>G	c.(181-183)GAG>GGG	p.E61G	CACNB1_uc002hrl.1_5'UTR|CACNB1_uc002hrn.2_Missense_Mutation_p.E61G|CACNB1_uc002hro.2_Missense_Mutation_p.E61G|CACNB1_uc002hrp.1_Missense_Mutation_p.E61G|CACNB1_uc010web.1_Missense_Mutation_p.E14G	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	61					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	GGTGTAGGACTCCGCTGAGCC	0.597													11	23					0	0	0	0	C	37347836	C	C	37347836	3	2	255	1	0	0	0	0	1	0	0	0	2564	1551	54	5	1926	5	CACNB1	17	37347836	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	1451737	37347836	43847374	155	46649											
GRB7	2886	broad.mit.edu	37	chr17	37899470	37899470	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacgagtccgtggtggaagtGcaggctgcctggcccgtggg	5	7	18	11	3	0	0	0	0	0	0	1	2	1	1	3	5	2	2	3	5	1	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:37899470G>T	uc002hsr.2	+	5	751	c.501G>T	c.(499-501)GTG>GTT	p.V167V	GRB7_uc002hss.2_Silent_p.V167V|GRB7_uc010cwc.2_Silent_p.V167V|GRB7_uc002hst.2_Silent_p.V167V	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	167	Ras-associating.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TGGTGGAAGTGCAGGCTGCCT	0.582													8	82					2.17888e-05	2.3853e-05	1	0	T	37899470	T	T	37899470	2	4	255	1	0	0	0	0	0	0	0	1	6798	1306	46	4		4	GRB7	17	37899470	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	551634	37899470	43295740	156	46650											
KLHL10	317719	broad.mit.edu	37	chr17	39994252	39994252	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catggagaggaagatgagtgCgatggcctgtgagatcttca	11	9	15	6	1	2	4	1	2	1	3	2	8	2	5	1	3	1	0	1	3	1	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:39994252C>T	uc010cxr.2	+	1	210	c.68C>T	c.(67-69)GCG>GTG	p.A23V	NT5C3L_uc010wfu.1_5'Flank|NT5C3L_uc002hyb.3_5'Flank|NT5C3L_uc002hyc.3_5'Flank|NT5C3L_uc002hyd.3_5'Flank|NT5C3L_uc002hxy.3_5'Flank|NT5C3L_uc002hxz.3_5'Flank|NT5C3L_uc002hya.3_5'Flank|KLHL10_uc010wfv.1_Missense_Mutation_p.A23V|KLHL10_uc010wfw.1_5'UTR	NM_152467	NP_689680	Q6JEL2	KLH10_HUMAN	kelch-like 10	23						cytoplasm				ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		Breast(137;0.000162)				AAGATGAGTGCGATGGCCTGT	0.562													38	73					0	0	0	0	T	39994252	T	T	39994252	3	4	255	1	0	0	0	0	1	0	0	0	8405	768	27	1	70	1	KLHL10	17	39994252	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	2094782	39994252	41200958	157	46651											
HELZ	9931	broad.mit.edu	37	chr17	65186378	65186378	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttcaattttatcagccgTgaagcatatcttttctgcca	9	17	6	9	1	4	1	2	1	2	0	4	1	4	1	2	0	3	2	2	0	4	6			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:65186378T>G	uc010wqk.1	-	10	838	c.651A>C	c.(649-651)TCA>TCC	p.S217S	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.S217S	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TTATCAGCCGTGAAGCATATC	0.393													12	50					0	0	0	0	G	65186378	G	G	65186378	2	3	255	1	0	0	0	0	0	0	0	1	7088	1683	59	5		5	HELZ	17	65186378	Silent	SNP	T	TCGA-CV-7418-01A-11D-2078-08	25192126	65186378	16008832	158	46652											
OTOP2	92736	broad.mit.edu	37	chr17	72929559	72929559	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tactccctctgggcggtcatCgtcaacatctgcctcccttt	5	13	7	16	2	4	0	2	0	2	0	7	0	6	0	3	2	3	0	3	2	2	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:72929559C>T	uc010wrp.1	+	8	1697	c.1608C>T	c.(1606-1608)ATC>ATT	p.I536I	OTOP3_uc010wrq.1_5'Flank|OTOP3_uc010wrr.1_5'Flank	NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	536	Helical; (Potential).					integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					GGGCGGTCATCGTCAACATCT	0.592													15	77					0	0	0	0	T	72929559	T	T	72929559	2	4	255	1	0	0	0	0	0	0	0	1	11360	874	31	1		1	OTOP2	17	72929559	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	7743181	72929559	8265651	159	46653											
ZNF750	79755	broad.mit.edu	37	chr17	80790003	80790003	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccaggttttccttgatgtCttccctggcagagctgtgct	4	15	10	12	0	1	2	0	1	1	1	4	2	4	2	3	2	2	4	3	2	0	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr17:80790003C>G	uc002kga.2	-	2	639	c.328G>C	c.(328-330)GAC>CAC	p.D110H	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	110						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TCCTTGATGTCTTCCCTGGCA	0.612													9	55					0	0	0	0	G	80790003	G	G	80790003	3	3	255	1	0	0	0	0	1	0	0	0	18199	913	32	2	1851	2	ZNF750	17	80790003	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	7860444	80790003	405207	160	46654											
ZNF521	25925	broad.mit.edu	37	chr18	22806653	22806653	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgaaaataattgtttgttgCagtaaatacagctgtaggta	14	15	9	3	0	0	1	0	1	0	0	0	1	0	1	0	1	3	7	0	1	8	9			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr18:22806653C>A	uc002kvk.2	-	4	1476	c.1229G>T	c.(1228-1230)TGC>TTC	p.C410F	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.C410F|ZNF521_uc002kvl.2_Missense_Mutation_p.C190F	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	410	C2H2-type 9; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TTGTTTGTTGCAGTAAATACA	0.438			T	PAX5	ALL								27	44					6.32553e-13	7.22918e-13	1	0	A	22806653	A	A	22806653	3	1	255	1	0	0	0	0	1	0	0	0	18032	710	25	4	2726	4	ZNF521	18	22806653	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08		22806653	55270595	161	46655											
CDH2	1000	broad.mit.edu	37	chr18	25589801	25589801	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctggcccagttacactgtaCcgcagtgaaaggtttttatc	9	12	9	11	1	0	1	0	1	0	0	1	1	0	1	3	2	2	4	3	2	4	5			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr18:25589801C>A	uc002kwg.2	-	5	1041	c.582G>T	c.(580-582)CGG>CGT	p.R194R	CDH2_uc010xbn.1_Silent_p.R163R	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	194	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TTACACTGTACCGCAGTGAAA	0.483													28	44					1.77063e-15	2.06905e-15	1	0	A	25589801	A	A	25589801	2	1	255	1	0	0	0	0	0	0	0	1	3120	494	18	4		4	CDH2	18	25589801	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	2783148	25589801	52487447	162	46656											
KLHL14	57565	broad.mit.edu	37	chr18	30350122	30350122	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagggacagggtcacgttggCcgtgtagaggtactcgagca	9	7	16	9	3	1	1	1	0	0	1	2	3	1	2	1	4	2	4	1	4	2	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr18:30350122C>T	uc002kxm.1	-	2	821	c.433G>A	c.(433-435)GCC>ACC	p.A145T		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	145	BTB.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						GTCACGTTGGCCGTGTAGAGG	0.637													38	130					0	0	0	0	T	30350122	T	T	30350122	3	4	255	1	0	0	0	0	1	0	0	0	8409	739	26	4	1485	4	KLHL14	18	30350122	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	4760321	30350122	47727126	163	46657											
CHAF1A	10036	broad.mit.edu	37	chr19	4432045	4432045	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaagcgctttcgcgtcctgCaacctgtgaagatcggctgc	7	9	13	12	4	0	2	0	1	0	1	3	3	1	3	2	2	4	3	2	2	3	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:4432045C>T	uc002mal.2	+	12	2144	c.2044C>T	c.(2044-2046)CAA>TAA	p.Q682*		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	682	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGCGTCCTGCAACCTGTGAA	0.602								Chromatin_Structure					25	56					0	0	0	0	T	4432045	T	T	4432045	4	4	255	1	0	0	0	0	0	1	0	0	3326	711	25	4	2090	4	CHAF1A	19	4432045	Nonsense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08		4432045	54696938	164	46658											
OR7E24	26648	broad.mit.edu	37	chr19	9361989	9361989	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtccttggctgacatcggTttcacctccaccacggtccc	5	11	8	17	2	1	1	1	1	0	0	5	1	4	1	5	3	0	2	5	3	0	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:9361989T>G	uc002mlb.1	+	1	270	c.270T>G	c.(268-270)GGT>GGG	p.G90G		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E,	90	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTGACATCGGTTTCACCTCCA	0.532													23	27					0	0	0	0	G	9361989	G	G	9361989	2	3	255	1	0	0	0	0	0	0	0	1	11275	1712	60	5		5	OR7E24	19	9361989	Silent	SNP	T	TCGA-CV-7418-01A-11D-2078-08	4929944	9361989	49766994	165	46659											
ICAM3	3385	broad.mit.edu	37	chr19	10446518	10446518	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcgggctgccggctcagctCctcctcccagcgaagcagca	6	6	12	17	3	1	0	1	0	0	0	4	1	4	0	4	2	6	5	4	2	1	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:10446518C>T	uc002mob.2	-	3	533	c.478G>A	c.(478-480)GAG>AAG	p.E160K	RAVER1_uc002moa.2_5'Flank|ICAM3_uc010dxd.1_Missense_Mutation_p.E83K|ICAM3_uc010xlf.1_Missense_Mutation_p.E83K	NM_002162	NP_002153	P32942	ICAM3_HUMAN	intercellular adhesion molecule 3 precursor	160	Extracellular (Potential).|Ig-like C2-type 2.				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			CGGCTCAGCTCCTCCTCCCAG	0.677													3	10					0	0	0	0	T	10446518	T	T	10446518	3	4	255	1	0	0	0	0	1	0	0	0	7520	864	30	2	1185	2	ICAM3	19	10446518	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	1084529	10446518	48682465	166	46660											
PGLYRP2	114770	broad.mit.edu	37	chr19	15587132	15587132	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctccacagccacggtcgAgccatcaggtgccagcacca	10	4	11	16	2	1	0	1	0	0	0	3	1	2	0	5	3	4	2	5	3	0	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:15587132A>T	uc002nbf.3	-	2	482	c.349T>A	c.(349-351)TCG>ACG	p.S117T	PGLYRP2_uc002nbg.3_Missense_Mutation_p.S117T	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	117					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						GCCACGGTCGAGCCATCAGGT	0.627													43	68					0	0	0	0	T	15587132	T	T	15587132	3	4	255	1	0	0	0	0	1	0	0	0	11849	304	11	5	1397	5	PGLYRP2	19	15587132	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	5140614	15587132	43541851	167	46661											
DDX49	54555	broad.mit.edu	37	chr19	19035702	19035702	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctccaggggcctggacaTccctacggtacaggtggtca	7	8	13	13	1	1	0	1	0	0	0	3	1	3	1	4	6	3	1	4	6	2	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:19035702T>A	uc002nkq.1	+	9	998	c.941T>A	c.(940-942)ATC>AAC	p.I314N	HOMER3_uc002nko.1_Intron|HOMER3_uc002nkp.1_Intron|DDX49_uc002nkr.1_RNA|DDX49_uc002nks.1_Missense_Mutation_p.I207N|DDX49_uc002nkt.1_3'UTR	NM_019070	NP_061943	Q9Y6V7	DDX49_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	314	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			Epithelial(12;0.0289)			GGCCTGGACATCCCTACGGTA	0.637													23	27					0	0	0	0	A	19035702	A	A	19035702	3	1	255	1	0	0	0	0	1	0	0	0	4383	1435	50	5	975	5	DDX49	19	19035702	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	3448570	19035702	40093281	168	46662											
HAPLN4	404037	broad.mit.edu	37	chr19	19369367	19369367	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaagcagaaggcgtcgtagCgttcctcggcgttatggcga	8	9	15	9	6	0	2	0	1	0	1	3	3	1	2	1	3	2	4	1	3	4	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:19369367C>T	uc002nmb.2	-	4	837	c.782G>A	c.(781-783)CGC>CAC	p.R261H	HAPLN4_uc002nmc.2_Missense_Mutation_p.R261H	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	261	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			GGCGTCGTAGCGTTCCTCGGC	0.687													20	24					0	0	0	0	T	19369367	T	T	19369367	3	4	255	1	0	0	0	0	1	0	0	0	6996	768	27	1	434	1	HAPLN4	19	19369367	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	333665	19369367	39759616	169	46663											
ZNF737	100129842	broad.mit.edu	37	chr19	20728176	20728176	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggtttctctccagtatgaAttatcttatgtgtagtaagg	10	16	10	5	0	2	1	0	1	2	0	4	1	3	1	1	2	0	4	1	2	6	6			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:20728176A>T	uc002npa.2	-	4	1013	c.833T>A	c.(832-834)ATT>AAT	p.I278N		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	278					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TCCAGTATGAATTATCTTATG	0.408													14	18					0	0	0	0	T	20728176	T	T	20728176	3	4	255	1	0	0	0	0	1	0	0	0	18193	101	4	5	781	5	ZNF737	19	20728176	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	1358809	20728176	38400807	170	46664											
ZNF573	126231	broad.mit.edu	37	chr19	38262306	38262306	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgccgagagaagtctatggCcacatccctgaatgtcacta	11	9	9	12	1	2	2	1	1	1	1	3	4	3	2	3	1	1	0	3	1	4	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:38262306C>T	uc002ohe.2	-	2	122	c.100G>A	c.(100-102)GCC>ACC	p.A34T	ZNF573_uc010efs.2_5'UTR|ZNF573_uc002ohd.2_Missense_Mutation_p.A32T|ZNF573_uc002ohf.2_5'UTR|ZNF573_uc002ohg.2_5'UTR	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	14	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			AAGTCTATGGCCACATCCCTG	0.408													6	22					0	0	0	0	T	38262306	T	T	38262306	3	4	255	1	0	0	0	0	1	0	0	0	18072	739	26	4	2034	4	ZNF573	19	38262306	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	17534130	38262306	20866677	171	46665											
GRIN2D	2906	broad.mit.edu	37	chr19	48946565	48946565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggcggcgcgtcgctgggcGgcctggagccctggtggttc	1	8	20	12	5	0	0	0	0	0	0	2	1	0	1	2	7	1	2	2	7	0	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-11A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	269e1950-5b9e-4b06-9dbe-d809e280243b	g.chr19:48946565G>A	uc002pjc.3	+	13	3470	c.3382G>A	c.(3382-3384)GGC>AGC	p.G1128S	GRIN2D_uc010elx.2_Missense_Mutation_p.G363S|GRWD1_uc002pjd.2_5'Flank	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	1128	Cytoplasmic (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GTCGCTGGGCGGCCTGGAGCC	0.637													6	8					0	0	0	0	A	48946565	A	A	48946565	3	1	255	1	0	0	0	0	1	0	0	0	6821	1116	39	1	3428	1	GRIN2D	19	48946565	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	10684259	48946565	10182418	172	46666											
FUT2	2524	broad.mit.edu	37	chr19	49206855	49206855	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcatgccaaaagtgtggaaGggggtggtggccgaccggcg	8	6	19	8	3	1	0	1	0	0	0	1	2	1	1	3	6	1	0	3	6	3	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:49206855G>C	uc002pke.3	+	2	753	c.642G>C	c.(640-642)AAG>AAC	p.K214N	FUT2_uc010emc.2_Missense_Mutation_p.K214N	NM_001097638	NP_001091107	Q10981	FUT2_HUMAN	fucosyltransferase 2	214	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			central_nervous_system(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		AAGTGTGGAAGGGGGTGGTGG	0.627													34	54					0	0	0	0	C	49206855	C	C	49206855	3	2	255	1	0	0	0	0	1	0	0	0	6138	991	35	4	644	4	FUT2	19	49206855	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	260290	49206855	9922128	173	46667											
FTL	2512	broad.mit.edu	37	chr19	49469858	49469861	+	Frame_Shift_Del	DEL	ACTC	-	-																															agctctgtgacttcctggagActcacttcctagatgaggaa																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:49469858_49469861delACTC	uc002plo.2	+	4	593_596	c.394_397delACTC	c.(394-399)ACTCACfs	p.T132fs	FTL_uc002pln.1_3'UTR	NM_000146	NP_000137	P02792	FRIL_HUMAN	ferritin, light polypeptide	132_133	Ferritin-like diiron.				cell death|cellular iron ion homeostasis|cellular membrane organization|iron ion transport|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|identical protein binding|oxidoreductase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000152)|all cancers(93;0.000435)|GBM - Glioblastoma multiforme(486;0.0171)|Epithelial(262;0.0267)	Iron Dextran(DB00893)	CTTCCTGGAGACTCACTTCCTAGA	0.525													---	---	---								-	49469861	-	-	49469858	7	5	255	1	0	1	0	1	0	0	0	0	6118	275	10	0	408	0	FTL	19	49469858	Frame_Shift_Del	DEL	ACTC	TCGA-CV-7418-01A-11D-2078-08	263003	49469858	9659125	174	46668											
BRSK1	84446	broad.mit.edu	37	chr19	55805723	55805723	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatatgatggccgccgggcAgacatgtggagctgtggagt	10	8	16	7	2	0	2	0	1	0	1	0	4	0	4	2	4	1	2	2	4	2	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr19:55805723A>C	uc002qkg.2	+	7	913	c.636A>C	c.(634-636)GCA>GCC	p.A212A	BRSK1_uc002qkf.2_Silent_p.A228A	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	212	Protein kinase.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GCCGCCGGGCAGACATGTGGA	0.587													10	24					0	0	0	0	C	55805723	C	C	55805723	2	2	255	1	0	0	0	0	0	0	0	1	1528	175	7	5		5	BRSK1	19	55805723	Silent	SNP	A	TCGA-CV-7418-01A-11D-2078-08	6335865	55805723	3323260	175	46669											
JAG1	182	broad.mit.edu	37	chr20	10620273	10620273	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcttctctgtctaccagcGtgtacgccggctgcttggca	4	13	10	14	3	3	0	0	0	3	0	5	0	3	0	2	2	4	4	2	2	2	4			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr20:10620273G>A	uc002wnw.2	-	26	4046	c.3530C>T	c.(3529-3531)ACG>ATG	p.T1177M		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	1177	Cytoplasmic (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GTCTACCAGCGTGTACGCCGG	0.507									Alagille_Syndrome				82	41					0	0	0	0	A	10620273	A	A	10620273	3	1	255	1	0	0	0	0	1	0	0	0	7973	1145	40	1	130	1	JAG1	20	10620273	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08		10620273	52405247	176	46670											
BTBD3	22903	broad.mit.edu	37	chr20	11903683	11903683	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaaaataaacgcaaggttcTaggaaaggcactttacttga	16	10	9	6	1	1	2	0	2	1	0	1	3	1	3	0	3	2	3	0	3	8	6			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr20:11903683T>A	uc002wnz.2	+	4	1297	c.938T>A	c.(937-939)CTA>CAA	p.L313Q	BTBD3_uc002wny.2_Missense_Mutation_p.L252Q|BTBD3_uc002woa.2_Missense_Mutation_p.L252Q|BTBD3_uc010zrf.1_Missense_Mutation_p.L162Q|BTBD3_uc010zrg.1_Missense_Mutation_p.L162Q|BTBD3_uc010zrh.1_Missense_Mutation_p.L162Q	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	313										ovary(2)|central_nervous_system(1)	3						CGCAAGGTTCTAGGAAAGGCA	0.463													37	37					0	0	0	0	A	11903683	A	A	11903683	3	1	255	1	0	0	0	0	1	0	0	0	1549	1522	53	5	952	5	BTBD3	20	11903683	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	1283410	11903683	51121837	177	46671											
CST9L	128821	broad.mit.edu	37	chr20	23545618	23545618	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tccaagcaggtcttgttcagGaggctgaactgagtcatcca	10	10	11	10	0	3	2	2	2	1	0	5	3	5	3	2	3	2	3	2	3	2	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr20:23545618G>C	uc002wtk.3	-	3	710	c.411C>G	c.(409-411)CTC>CTG	p.L137L		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	137						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					TCTTGTTCAGGAGGCTGAACT	0.552													21	19					0	0	0	0	C	23545618	C	C	23545618	2	2	255	1	0	0	0	0	0	0	0	1	3997	1161	41	2		2	CST9L	20	23545618	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08	11641935	23545618	39479902	178	46672											
CEP250	11190	broad.mit.edu	37	chr20	34090746	34090746	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagagagctcgagaaggatCgggagactcagaggaacgtc	13	5	15	8	3	2	4	2	0	0	4	5	9	2	6	0	3	2	1	0	3	2	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr20:34090746C>A	uc002xcm.2	+	31	5220	c.4549C>A	c.(4549-4551)CGG>AGG	p.R1517R	CEP250_uc010zve.1_Silent_p.R885R	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1517	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CGAGAAGGATCGGGAGACTCA	0.512													14	16					0.000151284	0.00016137	1	0	A	34090746	A	A	34090746	2	1	255	1	0	0	0	0	0	0	0	1	3267	875	31	3		3	CEP250	20	34090746	Silent	SNP	C	TCGA-CV-7418-01A-11D-2078-08	10545128	34090746	28934774	179	46673											
SYNJ1	8867	broad.mit.edu	37	chr21	34099218	34099218	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaacgccattctcctttcttCggaggcagccctgcgaaaac	9	9	9	14	3	2	0	0	0	2	0	4	3	2	1	3	2	4	1	3	2	3	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr21:34099218C>T	uc002yqh.2	-	2	106	c.106G>A	c.(106-108)GAA>AAA	p.E36K	SYNJ1_uc011ads.1_5'UTR|SYNJ1_uc002yqf.2_5'UTR|SYNJ1_uc002yqg.2_5'UTR|SYNJ1_uc002yqi.2_Missense_Mutation_p.E36K|uc002yqj.1_5'Flank|uc002yqk.2_5'Flank	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	Error:Variant_position_missing_in_O43426_after_alignment							inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						CTCCTTTCTTCGGAGGCAGCC	0.488													24	46					0	0	0	0	T	34099218	T	T	34099218	3	4	255	1	0	0	0	0	1	0	0	0	15518	893	31	1	4890	1	SYNJ1	21	34099218	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08		34099218	14030677	180	46674											
RIPK4	54101	broad.mit.edu	37	chr21	43166824	43166824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgccagcaccgctgcatgaGgcgtatcaggtggctgcagg	7	7	15	12	2	1	1	1	1	0	0	1	1	1	1	2	4	4	6	2	4	1	1	rs67846875		TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr21:43166824G>A	uc002yzn.1	-	5	829	c.781C>T	c.(781-783)CTC>TTC	p.L261F		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	261						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						CGCTGCATGAGGCGTATCAGG	0.672													22	42					0	0	0	0	A	43166824	A	A	43166824	3	1	255	1	0	0	0	0	1	0	0	0	13448	1000	35	4	1589	4	RIPK4	21	43166824	Missense_Mutation	SNP	G	TCGA-CV-7418-01A-11D-2078-08	9067606	43166824	4963071	181	46675											
PCNT	5116	broad.mit.edu	37	chr21	47841931	47841931	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgagcccggggtcaggaggcCctgaggctcaaactgctggt	7	7	16	11	1	2	2	2	2	0	0	2	3	2	3	2	6	3	2	2	6	1	0			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr21:47841931C>G	uc002zji.3	+	32	7179	c.7072C>G	c.(7072-7074)CCT>GCT	p.P2358A	PCNT_uc002zjj.2_Missense_Mutation_p.P2240A	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2358					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTCAGGAGGCCCTGAGGCTCA	0.612													22	49					0	0	0	0	G	47841931	G	G	47841931	3	3	255	1	0	0	0	0	1	0	0	0	11644	623	22	4	7198	4	PCNT	21	47841931	Missense_Mutation	SNP	C	TCGA-CV-7418-01A-11D-2078-08	4675107	47841931	287964	182	46676											
MYH9	4627	broad.mit.edu	37	chr22	36701124	36701124	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccatgaaacccttgggaatGgagtttggagtcaggatctc	10	11	12	8	0	2	1	1	1	1	0	4	5	3	5	2	4	1	1	2	4	2	2			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr22:36701124G>T	uc003apg.2	-	18	2415	c.2184C>A	c.(2182-2184)TCC>TCA	p.S728S	MYH9_uc003aph.1_Silent_p.S592S	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	728	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CCTTGGGAATGGAGTTTGGAG	0.537			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				20	45					2.37509e-13	2.72939e-13	1	0	T	36701124	T	T	36701124	2	4	255	1	0	0	0	0	0	0	0	1	10095	1335	47	4		4	MYH9	22	36701124	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08		36701124	14603442	183	46677											
NDUFA6	4700	broad.mit.edu	37	chr22	42482286	42482286	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatgtgtccgctgcttccaTactttaattgtttcttccag	7	17	6	11	1	1	0	0	0	1	0	4	0	4	0	3	0	2	3	3	0	2	7			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chr22:42482286T>C	uc003bcb.2	-	3	428	c.366A>G	c.(364-366)GTA>GTG	p.V122V		NM_002490	NP_002481	P56556	NDUA6_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	122					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	GCTGCTTCCATACTTTAATTG	0.383													28	59					0	0	0	0	C	42482286	C	C	42482286	2	2	255	1	0	0	0	0	0	0	0	1	10323	1393	49	5		5	NDUFA6	22	42482286	Silent	SNP	T	TCGA-CV-7418-01A-11D-2078-08	5781162	42482286	8822280	184	46678											
OTUD5	55593	broad.mit.edu	37	chrX	48780923	48780923	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcttaccaaaggcagagggGgacatctgctgaatgagggc	11	6	16	8	0	1	3	0	2	1	1	1	4	1	4	1	5	2	3	1	5	3	1			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chrX:48780923G>T	uc004dlu.2	-	8	1642	c.1581C>A	c.(1579-1581)TCC>TCA	p.S527S	OTUD5_uc004dlt.3_Silent_p.S522S|OTUD5_uc004dlv.2_Silent_p.S522S|OTUD5_uc011mmp.1_Silent_p.S305S	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	527					negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						AGGCAGAGGGGGACATCTGCT	0.607													8	3					0.000157383	0.000167019	1	0	T	48780923	T	T	48780923	2	4	255	1	0	0	0	0	0	0	0	1	11369	1219	43	4		4	OTUD5	23	48780923	Silent	SNP	G	TCGA-CV-7418-01A-11D-2078-08		48780923	106489637	185	46679											
ERCC6L	54821	broad.mit.edu	37	chrX	71426165	71426165	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagttcttctacacttccaaAcccctttggtaaagtagcta	12	13	5	11	0	2	0	0	0	2	0	3	0	3	0	3	1	3	4	3	1	7	8			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chrX:71426165A>C	uc004eaq.1	-	2	2549	c.2452T>G	c.(2452-2454)TTT>GTT	p.F818V	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Missense_Mutation_p.F695V	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	818					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					ACACTTCCAAACCCCTTTGGT	0.383													23	10					0	0	0	0	C	71426165	C	C	71426165	3	2	255	1	0	0	0	0	1	0	0	0	5242	43	2	5	1304	5	ERCC6L	23	71426165	Missense_Mutation	SNP	A	TCGA-CV-7418-01A-11D-2078-08	22645242	71426165	83844395	186	46680											
LPAR4	2846	broad.mit.edu	37	chrX	78011180	78011180	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaactctgtcctcttcttgTatgccctggtgcgctcccaa	6	13	7	15	1	3	0	0	0	3	0	5	0	5	0	3	1	3	2	3	1	3	3			TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chrX:78011180T>G	uc010nme.2	+	2	1219	c.814T>G	c.(814-816)TAT>GAT	p.Y272D		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	272	Helical; Name=6; (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						CCTCTTCTTGTATGCCCTGGT	0.408													21	9					0	0	0	0	G	78011180	G	G	78011180	3	3	255	1	0	0	0	0	1	0	0	0	8957	1638	57	5	816	5	LPAR4	23	78011180	Missense_Mutation	SNP	T	TCGA-CV-7418-01A-11D-2078-08	6585015	78011180	77259380	187	46681											
CAPN6	827	broad.mit.edu	37	chrX	110490693	110490698	+	In_Frame_Del	DEL	TCCTCC	-	-																															tctggacaggagaacggactTcctcctttccacatttgatg																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chrX:110490693_110490698delTCCTCC	uc004epc.1	-	12	1809_1814	c.1641_1646delGGAGGA	c.(1639-1647)AAGGAGGAA>AAA	p.EE548del	CAPN6_uc011msu.1_In_Frame_Del_p.EE293del	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	548_549	C2.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						AGAACGGACTTCCTCCTTTCCACATT	0.393													---	---	---								-	110490698	-	-	110490693	7	5	255	1	0	1	0	1	0	0	0	0	2642	1783	62	0	287	0	CAPN6	23	110490693	In_Frame_Del	DEL	TCCTCC	TCGA-CV-7418-01A-11D-2078-08	32479513	110490693	44779867	188	46682											
TBL1Y	90665	broad.mit.edu	37	chrY	6948772	6948773	+	Splice_Site	INS	-	C	C																															gtcctccctccctgctgcagINScccccgcccttgatgtggac																										TCGA-CV-7418-01A-11D-2078-08	TCGA-CV-7418-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	25a70d04-f533-4e60-b9fc-e74d600db296	7dbbc6b9-3e72-4914-b072-4d1a5af90c1f	g.chrY:6948772_6948773insC	uc004frb.2	+	14	1603	c.956_splice	c.e14-1	p.A319_splice	TBL1Y_uc004frc.2_Splice_Site_p.A319_splice|TBL1Y_uc004frd.2_Splice_Site_p.A319_splice|TBL1Y_uc011nap.1_Splice_Site_p.A161_splice	NM_033284	NP_150600	Q9BQ87	TBL1Y_HUMAN	transducin beta-like 1Y						transcription, DNA-dependent						0						CCCTGCTGCAGCCCCCGCCCTT	0.51													---	---	---								C	6948773	C	C	6948772	8	5	255	1	0	1	1	0	0	0	1	0	15707	985	34	0	989	0	TBL1Y	24	6948772	Splice_Site	INS	-	TCGA-CV-7418-01A-11D-2078-08		6948772	52424794	189	46683											
PPIH	10465	broad.mit.edu	37	chr1	43124905	43124905	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgtccctttcaggcagttCtgcaccggagaattcaggtc	7	13	10	11	1	3	1	2	0	1	1	5	2	4	1	2	3	1	3	2	3	1	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr1:43124905C>G	uc001chq.2	+	3	208	c.138C>G	c.(136-138)TTC>TTG	p.F46L	PPIH_uc009vwl.2_5'UTR	NM_006347	NP_006338	O43447	PPIH_HUMAN	peptidylprolyl isomerase H	46	PPIase cyclophilin-type.				protein complex assembly|protein folding	cytoplasm|nuclear speck|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|ribonucleoprotein binding				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)			L-Proline(DB00172)	TCAGGCAGTTCTGCACCGGAG	0.483													30	120					0	0	0	0	G	43124905	G	G	43124905	3	3	256	1	0	0	0	0	1	0	0	0	12385	912	32	2	148	2	PPIH	1	43124905	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08		43124905	206125716	1	46684											
GPSM2	29899	broad.mit.edu	37	chr1	109465042	109465042	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcctctcaatattttagaaaAtcagtgcagatactattgga	14	14	6	7	0	2	2	2	0	1	2	4	3	3	3	1	1	2	1	1	1	7	6			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr1:109465042A>G	uc010ovc.1	+	13	1940	c.1444A>G	c.(1444-1446)ATC>GTC	p.I482V	AKNAD1_uc010ovb.1_Intron|GPSM2_uc010ovd.1_Missense_Mutation_p.I482V|GPSM2_uc010ove.1_Missense_Mutation_p.I482V	NM_013296	NP_037428	P81274	GPSM2_HUMAN	LGN protein	482					G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		ATTTTAGAAAATCAGTGCAGA	0.318													16	19					0	0	0	0	G	109465042	G	G	109465042	3	3	256	1	0	0	0	0	1	0	0	0	6774	101	4	5	1490	5	GPSM2	1	109465042	Missense_Mutation	SNP	A	TCGA-CV-7421-01A-11D-2078-08	66340137	109465042	139785579	2	46685											
KPRP	448834	broad.mit.edu	37	chr1	152732431	152732431	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtgtcctacgtgcagtgcGaagcgtcacaacctgttcag	9	9	12	11	3	2	0	2	0	0	0	3	1	3	0	2	1	5	2	2	1	3	2			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr1:152732431G>A	uc001fal.1	+	2	425	c.367G>A	c.(367-369)GAA>AAA	p.E123K		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	123	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGTGCAGTGCGAAGCGTCACA	0.493													57	116					0	0	0	0	A	152732431	A	A	152732431	3	1	256	1	0	0	0	0	1	0	0	0	8475	1059	37	1	369	1	KPRP	1	152732431	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	43267389	152732431	96518190	3	46686											
RABGAP1L	9910	broad.mit.edu	37	chr1	174671345	174671345	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctcactctttttactgccaAgttcccactctgcatggtgt	6	16	6	13	0	3	0	1	0	3	0	5	0	4	0	2	1	3	2	2	1	2	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr1:174671345A>T	uc001gjx.2	+	17	2315	c.2120A>T	c.(2119-2121)AAG>ATG	p.K707M	RABGAP1L_uc001gkb.3_Translation_Start_Site|RABGAP1L_uc001gkc.3_Missense_Mutation_p.K14M|RABGAP1L_uc001gkd.3_Missense_Mutation_p.K33M	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	707	Rab-GAP TBC.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						TTTACTGCCAAGTTCCCACTC	0.428													7	52					0	0	0	0	T	174671345	T	T	174671345	3	4	256	1	0	0	0	0	1	0	0	0	13030	72	3	5	2182	5	RABGAP1L	1	174671345	Missense_Mutation	SNP	A	TCGA-CV-7421-01A-11D-2078-08	21938914	174671345	74579276	4	46687											
C1orf14	81626	broad.mit.edu	37	chr1	182909570	182909570	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccagttcctccaaaatctCatcaaccaaatctcttggaa	13	12	3	13	0	3	0	2	0	2	0	8	1	6	1	4	1	1	1	4	1	5	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr1:182909570C>T	uc001gpu.2	-	3	949	c.664G>A	c.(664-666)GAG>AAG	p.E222K	C1orf14_uc001gpv.2_Missense_Mutation_p.E103K|C1orf14_uc010pnz.1_Missense_Mutation_p.E80K|C1orf14_uc001gpw.2_5'UTR	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	294											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		TCCAAAATCTCATCAACCAAA	0.403													10	76					0	0	0	0	T	182909570	T	T	182909570	3	4	256	1	0	0	0	0	1	0	0	0	2009	835	29	2	1329	2	C1orf14	1	182909570	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08	8238225	182909570	66341051	5	46688											
OR2L3	391192	broad.mit.edu	37	chr1	248224417	248224417	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatgtgtgtgctgatgataaCagggtcttggatcataggct	10	13	13	5	0	2	2	1	2	1	0	2	3	2	3	0	3	2	2	0	3	3	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr1:248224417C>T	uc001idx.1	+	1	434	c.434C>T	c.(433-435)ACA>ATA	p.T145I	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTGATGATAACAGGGTCTTGG	0.423													11	124					0	0	0	0	T	248224417	T	T	248224417	3	4	256	1	0	0	0	0	1	0	0	0	11062	478	17	4	436	4	OR2L3	1	248224417	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08	65314847	248224417	1026204	6	46689											
ROCK2	9475	broad.mit.edu	37	chr2	11347878	11347878	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcagcattttgtttttcCaagttcattttcatttccat	8	21	4	8	0	3	0	3	0	0	0	5	0	5	0	2	0	1	4	2	0	1	9			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr2:11347878C>T	uc002rbd.1	-	20	2972	c.2523G>A	c.(2521-2523)TTG>TTA	p.L841L		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	841	Potential.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TTTGTTTTTCCAAGTTCATTT	0.303													5	27					0	0	0	0	T	11347878	T	T	11347878	2	4	256	1	0	0	0	0	0	0	0	1	13583	593	21	4		4	ROCK2	2	11347878	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08		11347878	231851495	7	46690											
FAM49A	81553	broad.mit.edu	37	chr2	16734259	16734259	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attcatcgttcaagtgctttGtagtgaacctggatggagag	10	13	12	6	1	2	2	2	1	0	1	3	4	2	3	1	2	2	3	1	2	3	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr2:16734259G>C	uc010exm.1	-	11	1065	c.917C>G	c.(916-918)ACA>AGA	p.T306R	FAM49A_uc002rck.1_Missense_Mutation_p.T306R	NM_030797	NP_110424	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	306						intracellular					0	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			CAAGTGCTTTGTAGTGAACCT	0.438													8	44					0	0	0	0	C	16734259	C	C	16734259	3	2	256	1	0	0	0	0	1	0	0	0	5607	1377	48	4	58	4	FAM49A	2	16734259	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	5386381	16734259	226465114	8	46691											
EIF2AK2	5610	broad.mit.edu	37	chr2	37347201	37347201	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaactttgtctagtttctcGcctcttcttttttcaatcca	8	19	3	11	1	5	0	1	0	4	0	7	0	6	0	2	0	1	1	2	0	4	7			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr2:37347201G>A	uc010ynh.1	-	13	1706	c.1149C>T	c.(1147-1149)GGC>GGT	p.G383G	EIF2AK2_uc010fab.1_Silent_p.G342G|EIF2AK2_uc010yng.1_Silent_p.G383G|EIF2AK2_uc010fac.2_Silent_p.G383G|EIF2AK2_uc010fad.2_Silent_p.G330G	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	383	Protein kinase.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				CTAGTTTCTCGCCTCTTCTTT	0.343													7	33					0	0	0	0	A	37347201	A	A	37347201	2	1	256	1	0	0	0	0	0	0	0	1	5019	1074	38	1		1	EIF2AK2	2	37347201	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08	20612942	37347201	205852172	9	46692											
LRPPRC	10128	broad.mit.edu	37	chr2	44204310	44204310	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttactcgatttggttgaatgTttgcttcctccatttttgcc	5	20	7	9	1	0	1	0	1	0	0	3	2	2	1	3	1	3	3	3	1	2	7			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr2:44204310T>C	uc002rtr.2	-	4	633	c.575A>G	c.(574-576)AAC>AGC	p.N192S	LRPPRC_uc010yob.1_Missense_Mutation_p.N92S|LRPPRC_uc010faw.1_Missense_Mutation_p.N166S	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	192	PPR 2.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGGTTGAATGTTTGCTTCCTC	0.289													25	29					0	0	0	0	C	44204310	C	C	44204310	3	2	256	1	0	0	0	0	1	0	0	0	9015	1725	60	5	3749	5	LRPPRC	2	44204310	Missense_Mutation	SNP	T	TCGA-CV-7421-01A-11D-2078-08	6857109	44204310	198995063	10	46693											
MRPL53	116540	broad.mit.edu	37	chr2	74699750	74699750	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaacccgaacctgtttgAcaggccgcagaccaagccga	12	5	10	14	3	0	3	0	2	0	1	0	5	0	3	5	1	3	2	5	1	3	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr2:74699750A>G	uc002sln.2	-	1	178	c.38T>C	c.(37-39)GTC>GCC	p.V13A	CCDC142_uc002slo.2_RNA	NM_053050	NP_444278	Q96EL3	RM53_HUMAN	mitochondrial ribosomal protein L53 precursor	13						mitochondrion|ribosome					0						AACCTGTTTGACAGGCCGCAG	0.592													6	56					0	0	0	0	G	74699750	G	G	74699750	3	3	256	1	0	0	0	0	1	0	0	0	9870	275	10	5	312	5	MRPL53	2	74699750	Missense_Mutation	SNP	A	TCGA-CV-7421-01A-11D-2078-08	30495440	74699750	168499623	11	46694											
AUP1	550	broad.mit.edu	37	chr2	74754072	74754072	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctctaaccccctcaccttcTtgcgtattcatatagtgctt	7	15	4	15	1	4	0	2	0	2	0	4	0	4	0	4	0	3	2	4	0	4	8			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr2:74754072T>C	uc010yrx.1	-	10	1489	c.1363A>G	c.(1363-1365)AGA>GGA	p.R455G	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_Missense_Mutation_p.R131G|AUP1_uc002smf.2_Missense_Mutation_p.R398G|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Missense_Mutation_p.R307G|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ57204, highly similar to Homo sapiens ancient ubiquitous protein 1 (AUP1), transcript variant 2, mRNA;	464	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						CCTCACCTTCTTGCGTATTCA	0.507													32	55					0	0	0	0	C	74754072	C	C	74754072	3	2	256	1	0	0	0	0	1	0	0	0	1222	1617	56	5	48	5	AUP1	2	74754072	Missense_Mutation	SNP	T	TCGA-CV-7421-01A-11D-2078-08	54322	74754072	168445301	12	46695											
POLR1A	25885	broad.mit.edu	37	chr2	86255166	86255166	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagatggcgagggtcgaccGcgatgcctgtcaaacgggag	10	5	17	9	5	1	1	1	0	0	1	2	6	1	2	2	3	2	0	2	3	1	0			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr2:86255166G>A	uc002sqs.2	-	33	5283	c.4904C>T	c.(4903-4905)GCG>GTG	p.A1635V	POLR1A_uc010ytb.1_Missense_Mutation_p.A1001V	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1635					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						AGGGTCGACCGCGATGCCTGT	0.542													8	28					0	0	0	0	A	86255166	A	A	86255166	3	1	256	1	0	0	0	0	1	0	0	0	12264	1087	38	1	266	1	POLR1A	2	86255166	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	11501094	86255166	156944207	13	46696											
NEB	4703	broad.mit.edu	37	chr2	152426612	152426612	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacatcgctctgcagttcgtAggccttcttggcctgaatca	7	12	9	13	2	3	1	1	1	2	0	5	1	3	1	2	2	1	4	2	2	2	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr2:152426612A>C	uc010fnx.2	-	81	12501	c.12310T>G	c.(12310-12312)TAC>GAC	p.Y4104D	NEB_uc002txr.2_Missense_Mutation_p.Y527D	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4104	Nebulin 112.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGCAGTTCGTAGGCCTTCTTG	0.507													2	9					0	0	0	0	C	152426612	C	C	152426612	3	2	256	1	0	0	0	0	1	0	0	0	10356	420	15	5	8569	5	NEB	2	152426612	Missense_Mutation	SNP	A	TCGA-CV-7421-01A-11D-2078-08	66171446	152426612	90772761	14	46697											
LRP2	4036	broad.mit.edu	37	chr2	170099508	170099508	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcactgcaatcaaaaacacCatcacaacgatttgtgacgc	15	8	6	12	2	3	1	3	1	0	0	3	2	3	1	1	0	3	1	1	0	4	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr2:170099508C>T	uc002ues.2	-	24	3838	c.3625G>A	c.(3625-3627)GGT>AGT	p.G1209S	LRP2_uc010zdf.1_Missense_Mutation_p.G1072S	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1209	LDL-receptor class A 12.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCAAAAACACCATCACAACGA	0.398													16	106					0	0	0	0	T	170099508	T	T	170099508	3	4	256	1	0	0	0	0	1	0	0	0	9006	594	21	4	10566	4	LRP2	2	170099508	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08	17672896	170099508	73099865	15	46698											
DZIP3	9666	broad.mit.edu	37	chr3	108355484	108355484	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttttagtgggaaaaaatgtTtgaaggaaggatgtacaggt	14	12	14	1	0	0	1	0	1	0	0	0	4	0	4	0	4	1	3	0	4	7	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr3:108355484T>A	uc003dxd.2	+	11	1362	c.940T>A	c.(940-942)TTG>ATG	p.L314M	DZIP3_uc003dxf.1_Missense_Mutation_p.L314M|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Missense_Mutation_p.L314M|DZIP3_uc003dxg.1_Missense_Mutation_p.L37M	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	314					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GAAAAAATGTTTGAAGGAAGG	0.264													8	111					0	0	0	0	A	108355484	A	A	108355484	3	1	256	1	0	0	0	0	1	0	0	0	4887	1838	64	5	978	5	DZIP3	3	108355484	Missense_Mutation	SNP	T	TCGA-CV-7421-01A-11D-2078-08		108355484	89666946	16	46699											
PIK3CB	5291	broad.mit.edu	37	chr3	138374244	138374244	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatcgttaagatctgtagTctttccgaactgtgtgggcc	7	14	11	9	2	2	2	0	1	2	1	4	3	3	2	2	1	1	2	2	1	3	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr3:138374244T>A	uc011bmq.1	-	22	3200	c.3200A>T	c.(3199-3201)GAC>GTC	p.D1067V	PIK3CB_uc011bmn.1_Missense_Mutation_p.D579V|PIK3CB_uc011bmo.1_Missense_Mutation_p.D518V|PIK3CB_uc011bmp.1_Missense_Mutation_p.D654V|PIK3CB_uc003est.1_RNA	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	1067	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AGATCTGTAGTCTTTCCGAAC	0.408													37	63					0	0	0	0	A	138374244	A	A	138374244	3	1	256	1	0	0	0	0	1	0	0	0	11969	1667	58	5	14	5	PIK3CB	3	138374244	Missense_Mutation	SNP	T	TCGA-CV-7421-01A-11D-2078-08	30018760	138374244	59648186	17	46700											
TRIM42	287015	broad.mit.edu	37	chr3	140406956	140406956	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caataaactacgtgcccttgGactttgttgagctttccagt	9	14	8	10	1	0	1	0	1	0	0	1	2	1	2	2	1	4	2	2	1	4	6			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr3:140406956G>T	uc003eto.1	+	3	1623	c.1432G>T	c.(1432-1434)GAC>TAC	p.D478Y		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	478	COS.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CGTGCCCTTGGACTTTGTTGA	0.602													11	22					5.50884e-06	1.32212e-05	1	0	T	140406956	T	T	140406956	3	4	256	1	0	0	0	0	1	0	0	0	16584	1174	41	2	1442	2	TRIM42	3	140406956	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	2032712	140406956	57615474	18	46701											
POLR2H	5437	broad.mit.edu	37	chr3	184082973	184082998	+	Frame_Shift_Del	DEL	GGATGATGGTGAATACAACCCCACTG	-	-																															ttgtatgaagatggtaccctGgatgatggtgaatacaaccc																								rs112012928		TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr3:184082973_184082998delGGATGATGGTGAATACAACCCCACTG	uc003fok.1	+	3	297_322	c.210_235delGGATGATGGTGAATACAACCCCACTG	c.(208-237)CTGGATGATGGTGAATACAACCCCACTGATfs	p.L70fs	POLR2H_uc003foj.1_RNA	NM_006232	NP_006223	P52434	RPAB3_HUMAN	RNA polymerase II, polypeptide H	70_79					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA-directed RNA polymerase activity|protein binding|zinc ion binding				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATGGTACCCTGGATGATGGTGAATACAACCCCACTGATGATAGGCC	0.407													---	---	---								-	184082998	-	-	184082973	7	5	256	1	0	1	0	1	0	0	0	0	12276	1335	47	0	220	0	POLR2H	3	184082973	Frame_Shift_Del	DEL	GGATGATGGTGAATACAACCCCACTG	TCGA-CV-7421-01A-11D-2078-08	43676017	184082973	13939457	19	46702											
RFC1	5981	broad.mit.edu	37	chr4	39310409	39310409	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaattttccactttgttttCactgctgtcatcagccaaat	10	16	4	11	0	3	0	3	0	0	0	4	0	4	0	2	0	2	2	2	0	2	5			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr4:39310409C>G	uc003gty.1	-	13	1866	c.1732G>C	c.(1732-1734)GAA>CAA	p.E578Q	RFC1_uc003gtx.1_Missense_Mutation_p.E578Q	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	578					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						ACTTTGTTTTCACTGCTGTCA	0.463													26	131					0	0	0	0	G	39310409	G	G	39310409	3	3	256	1	0	0	0	0	1	0	0	0	13309	835	29	2	1763	2	RFC1	4	39310409	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08		39310409	151843867	20	46703											
PTPN13	5783	broad.mit.edu	37	chr4	87692491	87692491	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agttacagtgacagcagtggGagtggagaagatgacttagt	13	9	15	4	0	0	4	0	2	0	2	0	6	0	5	0	2	2	2	0	2	3	2			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr4:87692491G>A	uc003hpz.2	+	31	5451	c.4971G>A	c.(4969-4971)GGG>GGA	p.G1657G	PTPN13_uc003hpy.2_Silent_p.G1662G|PTPN13_uc003hqa.2_Silent_p.G1638G|PTPN13_uc003hqb.2_Silent_p.G1466G|PTPN13_uc003hqc.1_Silent_p.G23G	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1657						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		ACAGCAGTGGGAGTGGAGAAG	0.453													4	4					0	0	0	0	A	87692491	A	A	87692491	2	1	256	1	0	0	0	0	0	0	0	1	12845	1161	41	2		2	PTPN13	4	87692491	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08	48382082	87692491	103461785	21	46704											
SYNPO2	171024	broad.mit.edu	37	chr4	119952308	119952308	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cacccaacctcctgccttccCcacatccaacccatcaaagg	11	6	3	21	0	1	0	1	0	0	0	4	0	4	0	8	1	3	0	8	1	3	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr4:119952308C>G	uc003icm.3	+	4	2574	c.2378C>G	c.(2377-2379)CCC>CGC	p.P793R	SYNPO2_uc010ina.2_Missense_Mutation_p.P793R|SYNPO2_uc010inb.2_Missense_Mutation_p.P793R|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.P721R	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	793	Pro-rich.					nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						CCTGCCTTCCCCACATCCAAC	0.567													4	61					0	0	0	0	G	119952308	G	G	119952308	3	3	256	1	0	0	0	0	1	0	0	0	15523	623	22	4	2392	4	SYNPO2	4	119952308	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08	32259817	119952308	71201968	22	46705											
FABP2	2169	broad.mit.edu	37	chr4	120243207	120243207	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttacccattttttccatgaaCttgtcatagttttcactccg	8	18	4	11	1	2	1	2	1	0	0	4	1	4	1	3	0	2	1	3	0	3	8			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr4:120243207C>T	uc003icw.2	-	1	110	c.51G>A	c.(49-51)AAG>AAA	p.K17K		NM_000134	NP_000125	P12104	FABPI_HUMAN	intestinal fatty acid binding protein 2	17							fatty acid binding			ovary(1)	1						TTTCCATGAACTTGTCATAGT	0.393													27	132					0	0	0	0	T	120243207	T	T	120243207	2	4	256	1	0	0	0	0	0	0	0	1	5385	564	20	4		4	FABP2	4	120243207	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08	290899	120243207	70911069	23	46706											
SLC6A3	6531	broad.mit.edu	37	chr5	1422042	1422042	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgaagtagagcagcacgatGaccagcaccaggcaggctgt	12	5	13	11	1	0	3	0	2	0	1	0	4	0	3	2	2	3	6	2	2	2	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr5:1422042G>C	uc003jck.2	-	5	862	c.741C>G	c.(739-741)GTC>GTG	p.V247V		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	247	Helical; Name=4; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	GCAGCACGATGACCAGCACCA	0.647													7	88					0	0	0	0	C	1422042	C	C	1422042	2	2	256	1	0	0	0	0	0	0	0	1	14749	1277	45	2		2	SLC6A3	5	1422042	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08		1422042	179493218	24	46707											
TRIO	7204	broad.mit.edu	37	chr5	14508431	14508431	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggcgtcctcgacacgtccaGactgacttccttcattgagc	7	10	10	14	3	1	3	1	2	0	1	5	4	4	3	3	1	1	0	3	1	0	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr5:14508431G>C	uc003jff.2	+	57	9200	c.9194G>C	c.(9193-9195)AGA>ACA	p.R3065T	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	3065					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GACACGTCCAGACTGACTTCC	0.592													4	67					0	0	0	0	C	14508431	C	C	14508431	3	2	256	1	0	0	0	0	1	0	0	0	16619	942	33	2	9420	2	TRIO	5	14508431	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	13086389	14508431	166406829	25	46708											
POLK	51426	broad.mit.edu	37	chr5	74892047	74892047	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgtgattggtttaatttagGtgttcggatatctagttttc	7	21	10	3	1	1	1	0	1	1	0	3	2	1	2	0	3	0	3	0	3	4	11			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr5:74892047G>A	uc003kdw.2	+	13	1625	c.1529G>A	c.(1528-1530)GGT>GAT	p.G510D	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc010izq.2_Missense_Mutation_p.G312D|POLK_uc003kec.2_Missense_Mutation_p.G420D|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Intron|POLK_uc003kee.2_Intron|POLK_uc003kef.2_Missense_Mutation_p.G420D	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	510					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TTTAATTTAGGTGTTCGGATA	0.373								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					8	12					0	0	0	0	A	74892047	A	A	74892047	3	1	256	1	0	0	0	0	1	0	0	0	12259	1275	44	4	1575	4	POLK	5	74892047	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	60383616	74892047	106023213	26	46709											
HLA-DRB5	3127	broad.mit.edu	37	chr6	32557568	32557569	+	5'Flank	INS	-	AT	AT																															gagaagcaggcaagtctcacINStcagggagaactatgaaccc																								rs17204758		TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr6:32557568_32557569insAT	uc003obk.3	-						HLA-DRB1_uc003obp.3_5'Flank	NM_002125	NP_002116	Q30154	DRB5_HUMAN	major histocompatibility complex, class II, DR						antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						GCAAGTCTCACTCAGGGAGAAC	0.54													---	---	---								AT	32557569	AT	AT	32557568	6	5	256	0	1	1	1	0	0	0	0	0	7248	580	20	0		0	HLA-DRB5	6	32557568	5'Flank	INS	-	TCGA-CV-7421-01A-11D-2078-08		32557568	138557499	27	46710											
LEMD2	221496	broad.mit.edu	37	chr6	33744932	33744933	+	Frame_Shift_Ins	INS	-	TC	TC																															acctataatcttcttcaccaINStctcatacatggcttgttcc																										TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr6:33744932_33744933insTC	uc011drm.1	-	7	1253_1254	c.1240_1241insGA	c.(1240-1242)ATGfs	p.M414fs	LEMD2_uc010jvg.2_Frame_Shift_Ins_p.M123fs|LEMD2_uc011drl.1_Frame_Shift_Ins_p.M112fs|LEMD2_uc003ofe.2_Frame_Shift_Ins_p.M112fs	NM_181336	NP_851853	Q8NC56	LEMD2_HUMAN	LEM domain containing 2 isoform 1	414						integral to nuclear inner membrane				central_nervous_system(1)	1						CTTCTTCACCATCTCATACATG	0.51													---	---	---								TC	33744933	TC	TC	33744932	7	5	256	1	0	1	1	0	0	0	0	0	8760	217	8	0	282	0	LEMD2	6	33744932	Frame_Shift_Ins	INS	-	TCGA-CV-7421-01A-11D-2078-08	1187364	33744932	137370135	28	46711											
UHRF1BP1	54887	broad.mit.edu	37	chr6	34826614	34826614	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattccccggcccatgtccgCgtgaggcttgaccactacca	7	8	9	17	3	0	2	0	2	0	0	2	2	2	2	6	2	1	1	6	2	1	3	rs149495470	by1000genomes	TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr6:34826614C>T	uc003oju.3	+	14	2715	c.2481C>T	c.(2479-2481)CGC>CGT	p.R827R	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	827										ovary(3)	3						CCCATGTCCGCGTGAGGCTTG	0.527													29	101					0	0	0	0	T	34826614	T	T	34826614	2	4	256	1	0	0	0	0	0	0	0	1	17036	755	27	1		1	UHRF1BP1	6	34826614	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08	1081682	34826614	136288453	29	46712											
SOBP	55084	broad.mit.edu	37	chr6	107956480	107956480	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaccttaataaccccgcggAcgaggaccatgcctatgctc	11	7	9	14	3	0	0	0	0	0	0	1	4	0	2	5	2	4	1	5	2	4	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr6:107956480A>G	uc003prx.2	+	6	2936	c.2432A>G	c.(2431-2433)GAC>GGC	p.D811G		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	811							metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		AACCCCGCGGACGAGGACCAT	0.647													16	46					0	0	0	0	G	107956480	G	G	107956480	3	3	256	1	0	0	0	0	1	0	0	0	14976	275	10	5	2454	5	SOBP	6	107956480	Missense_Mutation	SNP	A	TCGA-CV-7421-01A-11D-2078-08	73129866	107956480	63158587	30	46713											
TCF21	6943	broad.mit.edu	37	chr6	134210564	134210564	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggctccctcagcgatgtggAggaccttcaagaggtggaga	9	7	15	10	2	2	2	2	0	0	2	3	6	3	4	2	5	1	1	2	5	1	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr6:134210564A>G	uc003qei.3	+	1	305	c.29A>G	c.(28-30)GAG>GGG	p.E10G	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Missense_Mutation_p.E10G	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	10					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		AGCGATGTGGAGGACCTTCAA	0.383													6	60					0	0	0	0	G	134210564	G	G	134210564	3	3	256	1	0	0	0	0	1	0	0	0	15757	304	11	5	31	5	TCF21	6	134210564	Missense_Mutation	SNP	A	TCGA-CV-7421-01A-11D-2078-08	26254084	134210564	36904503	31	46714											
RSPH3	83861	broad.mit.edu	37	chr6	159403578	159403579	+	Frame_Shift_Ins	INS	-	TC	TC																															aacttcagcacgttcactatINStccgtagttcttcatactca																										TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr6:159403578_159403579insTC	uc003qrx.2	-	5	1250_1251	c.1060_1061insGA	c.(1060-1062)AATfs	p.N354fs	RSPH3_uc010kju.2_Frame_Shift_Ins_p.N258fs|RSPH3_uc003qry.1_Frame_Shift_Ins_p.N354fs	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	354	Potential.									ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		ACGTTCACTATTCCGTAGTTCT	0.431													---	---	---								TC	159403579	TC	TC	159403578	7	5	256	1	0	1	1	0	0	0	0	0	13770	1493	52	0	637	0	RSPH3	6	159403578	Frame_Shift_Ins	INS	-	TCGA-CV-7421-01A-11D-2078-08	25193014	159403578	11711489	32	46715											
PLEKHA8	84725	broad.mit.edu	37	chr7	30113748	30113748	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtagttcgaggggtttttgcGgtaagtgatccttcttgtct	5	17	13	6	2	2	1	0	1	2	0	4	2	3	1	1	3	1	4	1	3	2	7			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr7:30113748G>T	uc003tam.1	+	13	1453	c.1362G>T	c.(1360-1362)GCG>GCT	p.A454A	PLEKHA8_uc003tao.2_Silent_p.A338A|PLEKHA8_uc003tap.1_Silent_p.A454A|PLEKHA8_uc003tan.2_Intron	NM_032639	NP_116028	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A	454					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4						GGGTTTTTGCGGTAAGTGATC	0.403													10	11					0.00136819	0.00321228	1	0	T	30113748	T	T	30113748	2	4	256	1	0	0	0	0	0	0	0	1	12117	1131	39	3		3	PLEKHA8	7	30113748	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08		30113748	129024915	33	46716											
AP4M1	9179	broad.mit.edu	37	chr7	99703604	99703604	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccaggtttatctaaagttgCgatgtgacctgctctcaaag	10	13	9	9	1	2	1	1	1	2	0	4	2	3	1	2	1	2	3	2	1	4	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr7:99703604C>T	uc003utb.3	+	12	1160	c.952C>T	c.(952-954)CGA>TGA	p.R318*	AP4M1_uc011kjg.1_Nonsense_Mutation_p.R272*|AP4M1_uc010lgl.1_Nonsense_Mutation_p.R293*|AP4M1_uc003utc.3_Nonsense_Mutation_p.R325*|AP4M1_uc010lgm.2_Nonsense_Mutation_p.R190*|AP4M1_uc003utd.2_Nonsense_Mutation_p.R318*|AP4M1_uc011kjh.1_Nonsense_Mutation_p.R270*|AP4M1_uc003ute.3_Nonsense_Mutation_p.R93*|AP4M1_uc003utf.3_Nonsense_Mutation_p.R190*	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	318	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCTAAAGTTGCGATGTGACCT	0.552													10	106					0	0	0	0	T	99703604	T	T	99703604	4	4	256	1	0	0	0	0	0	1	0	0	753	760	27	1	998	1	AP4M1	7	99703604	Nonsense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08	69589856	99703604	59435059	34	46717											
CHRNB3	1142	broad.mit.edu	37	chr8	42587134	42587134	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttatcacgtattccttcgtCctgagacgcctgcctttatt	6	17	6	12	3	1	1	1	1	0	1	4	2	3	1	4	0	1	1	4	0	3	8			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr8:42587134C>G	uc003xpi.1	+	5	812	c.684C>G	c.(682-684)GTC>GTG	p.V228V		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	228	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			ATTCCTTCGTCCTGAGACGCC	0.478													28	57					0	0	0	0	G	42587134	G	G	42587134	2	3	256	1	0	0	0	0	0	0	0	1	3407	842	30	2		2	CHRNB3	8	42587134	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08		42587134	103776888	35	46718											
CHRNB3	1142	broad.mit.edu	37	chr8	42587173	42587173	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctataccctctttctcatCatcccctgcctggggctgtc	4	15	6	16	0	4	0	2	0	3	0	7	0	5	0	4	2	2	1	4	2	2	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr8:42587173C>A	uc003xpi.1	+	5	851	c.723C>A	c.(721-723)ATC>ATA	p.I241I		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	241	Helical; (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TCTTTCTCATCATCCCCTGCC	0.468													26	49					3.73988e-18	9.28523e-18	1	0	A	42587173	A	A	42587173	2	1	256	1	0	0	0	0	0	0	0	1	3407	816	29	2		2	CHRNB3	8	42587173	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08	39	42587173	103776849	36	46719											
PKHD1L1	93035	broad.mit.edu	37	chr8	110460576	110460576	+	Frame_Shift_Del	DEL	T	-	-																															ctcagccatgtccacagttgTatttgagtacccgcttaata																										TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr8:110460576delT	uc003yne.2	+	39	6085	c.5981delT	c.(5980-5982)GTAfs	p.V1994fs		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1994	Extracellular (Potential).|IPT/TIG 12.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCCACAGTTGTATTTGAGTAC	0.393										HNSCC(38;0.096)			---	---	---								-	110460576	-	-	110460576	7	5	256	1	0	1	0	1	0	0	0	0	12027	1638	57	0	6135	0	PKHD1L1	8	110460576	Frame_Shift_Del	DEL	T	TCGA-CV-7421-01A-11D-2078-08	67873403	110460576	35903446	37	46720											
FAM135B	51059	broad.mit.edu	37	chr8	139164397	139164397	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctctgggctactgatgtggGgagcagatacagacttggtt	8	11	14	8	0	1	3	0	1	1	2	1	4	1	4	1	4	3	3	1	4	2	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr8:139164397G>T	uc003yuy.2	-	13	2492	c.2321C>A	c.(2320-2322)CCC>CAC	p.P774H	FAM135B_uc003yux.2_Missense_Mutation_p.P675H|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.P336H|FAM135B_uc003yvb.2_Missense_Mutation_p.P336H	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	774										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACTGATGTGGGGAGCAGATAC	0.522										HNSCC(54;0.14)			8	99					1.58986e-06	3.85855e-06	1	0	T	139164397	T	T	139164397	3	4	256	1	0	0	0	0	1	0	0	0	5477	1232	43	4	1931	4	FAM135B	8	139164397	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	28703821	139164397	7199625	38	46721											
NAPRT1	93100	broad.mit.edu	37	chr8	144658293	144658293	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctcgtcaatgttgttgctGactacgatgaggactgactc	8	13	10	10	2	1	3	1	3	0	0	4	5	2	4	1	1	2	3	1	1	2	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr8:144658293G>A	uc003yym.3	-	8	1087	c.1062C>T	c.(1060-1062)GTC>GTT	p.V354V	NAPRT1_uc003yyn.3_Silent_p.V354V|NAPRT1_uc011lkh.1_Silent_p.V354V|NAPRT1_uc003yyo.3_Silent_p.V354V	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	354					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TGTTGTTGCTGACTACGATGA	0.672													12	40					0	0	0	0	A	144658293	A	A	144658293	2	1	256	1	0	0	0	0	0	0	0	1	10218	1277	45	2		2	NAPRT1	8	144658293	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08	5493896	144658293	1705729	39	46722											
SUSD1	64420	broad.mit.edu	37	chr9	114911525	114911525	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcccccttcttgagtaccTgtacaaaaggtgccatcgtt	9	11	8	13	1	1	1	0	1	1	0	2	1	1	1	4	1	4	3	4	1	4	5			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr9:114911525T>A	uc004bfu.2	-	3	413	c.372A>T	c.(370-372)ACA>ACT	p.T124T	SUSD1_uc010mui.2_Silent_p.T124T|SUSD1_uc010muj.2_Silent_p.T124T	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	124	Extracellular (Potential).					integral to membrane	calcium ion binding				0						CTTGAGTACCTGTACAAAAGG	0.328													39	211					0	0	0	0	A	114911525	A	A	114911525	2	1	256	1	0	0	0	0	0	0	0	1	15473	1594	55	5		5	SUSD1	9	114911525	Silent	SNP	T	TCGA-CV-7421-01A-11D-2078-08		114911525	26301906	40	46723											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123239729	123239729	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgatgattgtttcttttcCtggaaatgacaatgggcatt	9	17	9	6	0	2	3	0	3	2	0	3	4	3	4	1	2	0	2	1	2	2	5			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr9:123239729C>T	uc004bkf.2	-	15	1808	c.1627_splice	c.e15-1	p.E543_splice	CDK5RAP2_uc004bkg.2_Splice_Site_p.E543_splice|CDK5RAP2_uc011lxw.1_Splice_Site|CDK5RAP2_uc011lxx.1_Splice_Site|CDK5RAP2_uc011lxy.1_Splice_Site|CDK5RAP2_uc011lxz.1_Splice_Site|CDK5RAP2_uc011lya.1_Splice_Site|CDK5RAP2_uc004bkh.1_Splice_Site_p.E543_splice|CDK5RAP2_uc004bki.2_Splice_Site_p.E342_splice	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2						brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						GTTTCTTTTCCTGGAAATGAC	0.358											OREG0019439	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	60					0	0	0	0	T	123239729	T	T	123239729	5	4	256	1	0	0	0	0	0	0	1	0	3161	695	24	4	4151	4	CDK5RAP2	9	123239729	Splice_Site	SNP	C	TCGA-CV-7421-01A-11D-2078-08	8328204	123239729	17973702	41	46724											
SGPL1	8879	broad.mit.edu	37	chr10	72636950	72636950	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtctctttctttggatttgtAgggtgccatctatggcatgg	5	17	12	7	0	3	0	0	0	3	0	4	1	3	1	1	4	1	2	1	4	2	5			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr10:72636950A>G	uc001jrm.2	+	15	1789	c.1567_splice	c.e15-2	p.G523_splice	SGPL1_uc009xqk.2_Splice_Site	NM_003901	NP_003892	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1						apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity				0					Pyridoxal Phosphate(DB00114)	TTGGATTTGTAGGGTGCCATC	0.483													3	29					0	0	0	0	G	72636950	G	G	72636950	5	3	256	1	0	0	0	0	0	0	1	0	14283	434	15	5	1619	5	SGPL1	10	72636950	Splice_Site	SNP	A	TCGA-CV-7421-01A-11D-2078-08		72636950	62897797	42	46725											
SYNPO2L	79933	broad.mit.edu	37	chr10	75407893	75407893	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgaagacaagaaggggggtGgggcggggctgaggcccccc	8	2	21	10	2	0	3	0	1	0	2	0	4	0	3	3	8	0	1	3	8	3	0			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr10:75407893G>A	uc001jut.3	-	4	1669	c.1517C>T	c.(1516-1518)CCA>CTA	p.P506L	SYNPO2L_uc001jus.3_Missense_Mutation_p.P282L	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	506	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					GAAGGGGGGTGGGGCGGGGCT	0.677													3	8					0	0	0	0	A	75407893	A	A	75407893	3	1	256	1	0	0	0	0	1	0	0	0	15524	1348	47	4	1420	4	SYNPO2L	10	75407893	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	2770943	75407893	60126854	43	46726											
MUC5B	727897	broad.mit.edu	37	chr11	1270883	1270883	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagctgaccacaacagccaCtacgactgcatccactggat	13	6	8	14	1	0	2	0	1	0	1	1	4	1	3	3	1	5	2	3	1	2	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr11:1270883C>G	uc009ycr.1	+	51	14318	c.14192C>G	c.(14191-14193)ACT>AGT	p.T4731S	MUC5B_uc001ltb.2_Missense_Mutation_p.T4261S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4258	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACAACAGCCACTACGACTGCA	0.677													4	63					0	0	0	0	G	1270883	G	G	1270883	3	3	256	1	0	0	0	0	1	0	0	0	10032	565	20	4	12904	4	MUC5B	11	1270883	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08		1270883	133735633	44	46727											
CALCB	797	broad.mit.edu	37	chr11	15098881	15098881	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgccacctgtgtgactcatCggctggcaggcttgctgagc	5	10	13	13	1	1	2	1	2	0	0	2	2	1	2	2	3	3	4	2	3	0	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr11:15098881C>T	uc001mlx.1	+	4	347	c.274C>T	c.(274-276)CGG>TGG	p.R92W	CALCB_uc009ygr.1_Missense_Mutation_p.R92W	NM_000728	NP_000719	P10092	CALCB_HUMAN	calcitonin-related polypeptide, beta precursor	92					cellular calcium ion homeostasis|signal transduction|vasodilation	extracellular region|soluble fraction	neuropeptide hormone activity				0						TGTGACTCATCGGCTGGCAGG	0.567													6	11					0	0	0	0	T	15098881	T	T	15098881	3	4	256	1	0	0	0	0	1	0	0	0	2588	875	31	1	284	1	CALCB	11	15098881	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08	13827998	15098881	119907635	45	46728											
LRRC4C	57689	broad.mit.edu	37	chr11	40136993	40136993	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagggagtgaagaggtcatGaggcagtaatgttagattat	14	10	14	3	0	1	4	1	2	0	2	1	5	1	5	0	3	0	3	0	3	5	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr11:40136993G>A	uc001mxa.1	-	2	2814	c.850C>T	c.(850-852)CAT>TAT	p.H284Y	LRRC4C_uc001mxc.1_Missense_Mutation_p.H280Y|LRRC4C_uc001mxd.1_Missense_Mutation_p.H280Y|LRRC4C_uc001mxb.1_Missense_Mutation_p.H280Y	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	284	LRR 9.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				AAGAGGTCATGAGGCAGTAAT	0.443													37	58					0	0	0	0	A	40136993	A	A	40136993	3	1	256	1	0	0	0	0	1	0	0	0	9058	1290	45	2	1076	2	LRRC4C	11	40136993	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	25038112	40136993	94869523	46	46729											
RAPSN	5913	broad.mit.edu	37	chr11	47464319	47464319	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcctttgccatagttgttGacaagctctgccgccttgca	7	12	9	13	1	1	1	0	1	1	0	1	1	1	1	4	0	5	4	4	0	2	5			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr11:47464319G>C	uc001nfi.1	-	3	793	c.579C>G	c.(577-579)GTC>GTG	p.V193V	RAPSN_uc001nfj.1_Silent_p.V193V|RAPSN_uc009yls.1_Silent_p.V193V	NM_005055	NP_005046	Q13702	RAPSN_HUMAN	43 kD receptor-associated protein of the synapse	193	TPR 4.				synaptic transmission, cholinergic	cell junction|cytoskeleton|postsynaptic membrane	acetylcholine receptor binding|zinc ion binding			ovary(1)	1						CATAGTTGTTGACAAGCTCTG	0.612													13	26					0	0	0	0	C	47464319	C	C	47464319	2	2	256	1	0	0	0	0	0	0	0	1	13116	1277	45	2		2	RAPSN	11	47464319	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08	7327326	47464319	87542197	47	46730											
SORL1	6653	broad.mit.edu	37	chr11	121384941	121384941	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccgcaccaatttatacatCtcagaggcagaggggctgaa	14	7	10	10	1	1	3	1	1	1	2	2	3	1	3	2	3	2	3	2	3	5	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr11:121384941C>T	uc001pxx.2	+	8	1202	c.1122C>T	c.(1120-1122)ATC>ATT	p.I374I		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	374	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ATTTATACATCTCAGAGGCAG	0.507													6	75					0	0	0	0	T	121384941	T	T	121384941	2	4	256	1	0	0	0	0	0	0	0	1	14998	903	32	2		2	SORL1	11	121384941	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08	73920622	121384941	13621575	48	46731											
GAPDH	2597	broad.mit.edu	37	chr12	6646508	6646508	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accaccaactgcttagcaccCctggccaaggtcatccatga	11	7	7	16	0	1	1	1	1	0	0	2	1	2	1	6	2	3	2	6	2	3	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr12:6646508C>T	uc001qop.1	+	7	579	c.477C>T	c.(475-477)CCC>CCT	p.P159P	GAPDH_uc009zep.1_Silent_p.P117P|GAPDH_uc001qoq.1_Silent_p.P84P|GAPDH_uc001qor.1_Silent_p.P118P|GAPDH_uc001qos.1_Silent_p.P159P|GAPDH_uc001qot.1_Silent_p.P159P|GAPDH_uc001qou.1_Silent_p.P118P|GAPDH_uc001qov.1_Silent_p.P117P|GAPDH_uc001qow.1_Silent_p.P112P|GAPDH_uc001qox.1_5'UTR	NM_002046	NP_002037	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	159					gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding				0					NADH(DB00157)	GCTTAGCACCCCTGGCCAAGG	0.577													15	39					0	0	0	0	T	6646508	T	T	6646508	2	4	256	1	0	0	0	0	0	0	0	1	6271	610	22	4		4	GAPDH	12	6646508	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08		6646508	127205387	49	46732											
SOAT2	8435	broad.mit.edu	37	chr12	53516948	53516948	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catgagtatatcttctgcttCgtcctggggttcttctatcc	5	17	8	11	1	4	1	0	1	4	0	7	1	6	1	2	2	1	3	2	2	3	7			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr12:53516948C>T	uc001sbv.2	+	13	1408	c.1320C>T	c.(1318-1320)TTC>TTT	p.F440F	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	440	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						TCTTCTGCTTCGTCCTGGGGT	0.592													14	37					0	0	0	0	T	53516948	T	T	53516948	2	4	256	1	0	0	0	0	0	0	0	1	14975	883	31	1		1	SOAT2	12	53516948	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08	46870440	53516948	80334947	50	46733											
RDH16	8608	broad.mit.edu	37	chr12	57351084	57351084	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagacatgcagccagcacccGcaagcctcgtgcatccagct	10	5	9	17	2	0	1	0	0	0	1	2	1	1	1	4	0	6	5	4	0	1	0			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr12:57351084G>T	uc001smi.3	-	1	335	c.163C>A	c.(163-165)CGG>AGG	p.R55R	RDH16_uc009zpa.2_5'UTR|RDH16_uc010sqx.1_RNA	NM_003708	NP_003699	O75452	RDH16_HUMAN	retinol dehydrogenase 16	55	NAD (By similarity).|Cytoplasmic (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity				0						GCCAGCACCCGCAAGCCTCGT	0.587													10	33					1.08611e-07	2.6659e-07	1	0	T	57351084	T	T	57351084	2	4	256	1	0	0	0	0	0	0	0	1	13259	1086	38	3		3	RDH16	12	57351084	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08	3834136	57351084	76500811	51	46734											
NHLRC3	387921	broad.mit.edu	37	chr13	39618272	39618272	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaaaatgggacagggcctgCtaagttcaacatacctcaca	15	7	9	10	0	2	1	2	0	0	1	2	2	2	2	2	2	3	2	2	2	5	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr13:39618272C>G	uc001uxc.2	+	5	954	c.632C>G	c.(631-633)GCT>GGT	p.A211G	NHLRC3_uc001uxb.1_Missense_Mutation_p.A211G|NHLRC3_uc001uxd.2_Missense_Mutation_p.A144G|NHLRC3_uc001uxe.2_Missense_Mutation_p.A14G	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	211	NHL 3.					extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		ACAGGGCCTGCTAAGTTCAAC	0.383													69	80					0	0	0	0	G	39618272	G	G	39618272	3	3	256	1	0	0	0	0	1	0	0	0	10461	797	28	4	650	4	NHLRC3	13	39618272	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08		39618272	75551606	52	46735											
OR4K17	390436	broad.mit.edu	37	chr14	20585923	20585923	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctgaacttgttaaaaaagCagaaggtaatttcttttgct	13	16	7	5	0	2	2	0	1	2	1	2	2	2	2	0	1	3	4	0	1	6	7			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr14:20585923C>G	uc001vwo.1	+	1	358	c.358C>G	c.(358-360)CAG>GAG	p.Q120E		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GTTAAAAAAGCAGAAGGTAAT	0.413													45	78					0	0	0	0	G	20585923	G	G	20585923	3	3	256	1	0	0	0	0	1	0	0	0	11125	711	25	4	360	4	OR4K17	14	20585923	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08		20585923	86763617	53	46736											
OR11H6	122748	broad.mit.edu	37	chr14	20692287	20692287	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcagttatggcttatgatcGgtacctggccatctgtcgtc	7	14	10	10	2	2	1	1	1	1	0	5	1	2	1	2	3	1	3	2	3	3	3	rs146448571		TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr14:20692287G>A	uc010tlc.1	+	1	419	c.419G>A	c.(418-420)CGG>CAG	p.R140Q		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	140	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		GCTTATGATCGGTACCTGGCC	0.428													10	81					0	0	0	0	A	20692287	A	A	20692287	3	1	256	1	0	0	0	0	1	0	0	0	10983	1116	39	1	421	1	OR11H6	14	20692287	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	106364	20692287	86657253	54	46737											
SPATA7	55812	broad.mit.edu	37	chr14	88892892	88892892	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatcttttggataaacattCtgaactcttttctaacaaac	13	15	5	8	0	4	1	0	1	4	0	4	3	4	3	0	2	4	0	0	2	5	7			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr14:88892892C>G	uc001xwq.2	+	6	840	c.689C>G	c.(688-690)TCT>TGT	p.S230C	SPATA7_uc001xwr.2_Missense_Mutation_p.S198C|SPATA7_uc001xws.2_Missense_Mutation_p.S166C|SPATA7_uc001xwt.2_Missense_Mutation_p.S124C|SPATA7_uc001xwu.2_5'Flank	NM_018418	NP_060888	Q9P0W8	SPAT7_HUMAN	spermatogenesis-associated protein 7 isoform a	230					response to stimulus|visual perception					ovary(1)	1						GATAAACATTCTGAACTCTTT	0.428													15	51					0	0	0	0	G	88892892	G	G	88892892	3	3	256	1	0	0	0	0	1	0	0	0	15080	913	32	2	711	2	SPATA7	14	88892892	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08	68200605	88892892	18456648	55	46738											
DYNC1H1	1778	broad.mit.edu	37	chr14	102502847	102502847	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatccgctgatcattgacccCtctggacaggccacagaatt	10	10	8	13	1	2	3	1	2	1	1	3	4	3	4	4	2	0	1	4	2	2	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr14:102502847C>A	uc001yks.2	+	57	10940	c.10776C>A	c.(10774-10776)CCC>CCA	p.P3592P		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3592	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TCATTGACCCCTCTGGACAGG	0.488													13	67					0.00185496	0.00430829	1	0	A	102502847	A	A	102502847	2	1	256	1	0	0	0	0	0	0	0	1	4863	668	24	4		4	DYNC1H1	14	102502847	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08	13609955	102502847	4846693	56	46739											
BTBD1	53339	broad.mit.edu	37	chr15	83710628	83710628	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaacagctccaaaaagtcgActttctcgaatactgagtgt	14	10	7	10	2	1	1	0	1	1	0	4	3	2	1	1	0	3	1	1	0	5	2			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr15:83710628A>G	uc002bjn.2	-	4	917	c.714T>C	c.(712-714)AGT>AGC	p.S238S	BTBD1_uc002bjo.2_Silent_p.S238S	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	238						cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		CAAAAAGTCGACTTTCTCGAA	0.373													18	39					0	0	0	0	G	83710628	G	G	83710628	2	3	256	1	0	0	0	0	0	0	0	1	1542	272	10	5		5	BTBD1	15	83710628	Silent	SNP	A	TCGA-CV-7421-01A-11D-2078-08		83710628	18820764	57	46740											
TNRC6A	27327	broad.mit.edu	37	chr16	24801106	24801106	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacaatggacttgccctaaaAgggcctgtagggagtggtag	12	8	14	7	0	0	0	0	0	0	0	0	2	0	2	2	4	2	2	2	4	6	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr16:24801106A>G	uc002dmm.2	+	6	1257	c.1143A>G	c.(1141-1143)AAA>AAG	p.K381K	TNRC6A_uc010bxs.2_Silent_p.K128K|TNRC6A_uc010vcc.1_Silent_p.K128K|TNRC6A_uc002dmn.2_Silent_p.K128K|TNRC6A_uc002dmo.2_Silent_p.K128K	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	381	Sufficient for interaction with EIF2C1, EIF2C3 and EIF2C4.|Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TTGCCCTAAAAGGGCCTGTAG	0.428													3	57					0	0	0	0	G	24801106	G	G	24801106	2	3	256	1	0	0	0	0	0	0	0	1	16406	69	3	5		5	TNRC6A	16	24801106	Silent	SNP	A	TCGA-CV-7421-01A-11D-2078-08		24801106	65553647	58	46741											
SLC5A2	6524	broad.mit.edu	37	chr16	31500299	31500299	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgattacatccaggcagtctCtagctacctggcaccgcccg	8	8	9	16	3	1	0	0	0	1	0	3	1	2	0	4	2	3	3	4	2	3	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr16:31500299C>G	uc002ecf.3	+	11	1398	c.1379C>G	c.(1378-1380)TCT>TGT	p.S460C	SLC5A2_uc010car.2_Intron|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	460	Helical; (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						CAGGCAGTCTCTAGCTACCTG	0.662													10	18					0	0	0	0	G	31500299	G	G	31500299	3	3	256	1	0	0	0	0	1	0	0	0	14729	913	32	2	1421	2	SLC5A2	16	31500299	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08	6699193	31500299	58854454	59	46742											
TMEM188	255919	broad.mit.edu	37	chr16	50063658	50063658	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcttatagtggtatctgtCtgtacagctactggtgcctg	6	16	10	9	0	3	0	0	0	3	0	3	0	3	0	1	2	4	3	1	2	5	6			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr16:50063658C>G	uc002efu.2	+	3	158	c.120C>G	c.(118-120)GTC>GTG	p.V40V	TMEM188_uc002eft.2_Silent_p.V57V|TMEM188_uc002efv.2_Intron			Q8N9A8	TM188_HUMAN	SubName: Full=TMP125; SubName: Full=Putative uncharacterized protein FLJ38101;	40	Helical; (Potential).					integral to membrane					0						TGGTATCTGTCTGTACAGCTA	0.338													3	35					0	0	0	0	G	50063658	G	G	50063658	2	3	256	1	0	0	0	0	0	0	0	1	16176	900	32	2		2	TMEM188	16	50063658	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08	18563359	50063658	40291095	60	46743											
TP53	7157	broad.mit.edu	37	chr17	7578549	7578550	+	Missense_Mutation	DNP	GG	AA	AA																															aacatcttgttgagggcaggGgagtactgtaggaagaggaa																										TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr17:7578549_7578550GG>AA	uc002gim.2	-	5	574_575	c.380_381CC>TT	c.(379-381)TCC>TTT	p.S127F	TP53_uc002gig.1_Missense_Mutation_p.S127F|TP53_uc002gih.2_Missense_Mutation_p.S127F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.S127F|TP53_uc010cni.1_Missense_Mutation_p.S127F|TP53_uc002gij.2_Missense_Mutation_p.S127F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.S34F|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.S88F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	127	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		S -> C (in a sporadic cancer; somatic mutation).|S -> F (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S127F(18)|p.S127Y(8)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.Y126_N131delYSPALN(3)|p.S127P(3)|p.S127T(2)|p.P128fs*42(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.P128fs*18(1)|p.Y126fs*11(1)|p.S127S(1)|p.S127C(1)|p.S127_Q136del10(1)|p.P13fs*18(1)|p.?(1)|p.S127fs*43(1)|p.S127fs*42(1)|p.Y126fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGAGGGCAGGGGAGTACTGTAG	0.554		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	11					0	0	0	0	AA	7578550	AA	AA	7578549	3	1	256	1	0	0	0	0	1	0	0	0	16448	1219	43	4	917	4	TP53	17	7578549	Missense_Mutation	DNP	GG	TCGA-CV-7421-01A-11D-2078-08		7578549	73616661	61	46744											
RARA	5914	broad.mit.edu	37	chr17	38508322	38508322	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagctgggcaaatacactacGgtatggctttcccccggcct	8	9	10	14	2	0	0	0	0	0	0	1	0	1	0	3	4	3	4	3	4	4	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr17:38508322G>A	uc002huk.1	+	5	1085	c.630G>A	c.(628-630)ACG>ACA	p.T210T	RARA_uc002hul.3_Silent_p.T210T|RARA_uc010wfe.1_Silent_p.T113T|RARA_uc002hun.1_Silent_p.T205T	NM_000964	NP_000955	P10276	RARA_HUMAN	retinoic acid receptor, alpha isoform 1	210	Ligand-binding.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	AATACACTACGGTATGGCTTT	0.632			T	PML|ZNF145|TIF1|NUMA1|NPM1	APL								4	4					0	0	0	0	A	38508322	A	A	38508322	2	1	256	1	0	0	0	0	0	0	0	1	13117	1130	39	1		1	RARA	17	38508322	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08	30929773	38508322	42686888	62	46745											
EPX	8288	broad.mit.edu	37	chr17	56280505	56280505	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatttggcacagcttagccGggtgctgaaaaaccaggact	12	8	12	9	1	0	1	0	1	0	0	0	3	0	2	2	3	4	3	2	3	4	2	rs149971221	byFrequency	TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr17:56280505G>A	uc002ivq.2	+	11	1858	c.1772G>A	c.(1771-1773)CGG>CAG	p.R591Q		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	591					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						CAGCTTAGCCGGGTGCTGAAA	0.542													49	50					0	0	0	0	A	56280505	A	A	56280505	3	1	256	1	0	0	0	0	1	0	0	0	5224	1116	39	1	1814	1	EPX	17	56280505	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	17772183	56280505	24914705	63	46746											
ABCA9	10350	broad.mit.edu	37	chr17	67020425	67020425	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcactttgtgctgtcaatttGgcatcagagatgtgctgctt	7	16	10	8	0	3	1	3	0	0	1	3	2	3	1	0	1	3	4	0	1	1	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr17:67020425G>T	uc002jhu.2	-	17	2354	c.2211C>A	c.(2209-2211)GCC>GCA	p.A737A	ABCA9_uc010dez.2_Silent_p.A737A	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	737					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CTGTCAATTTGGCATCAGAGA	0.323													6	15					0.00116845	0.00277345	1	0	T	67020425	T	T	67020425	2	4	256	1	0	0	0	0	0	0	0	1	39	1335	47	4		4	ABCA9	17	67020425	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08	10739920	67020425	14174785	64	46747											
MC2R	4158	broad.mit.edu	37	chr18	13885087	13885087	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccaccacagtgcggcgcAtggtcacgatgctgtggtac	8	7	13	13	3	1	0	1	0	0	0	1	1	1	0	2	3	3	4	2	3	1	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr18:13885087A>G	uc002ksp.1	-	2	608	c.431T>C	c.(430-432)ATG>ACG	p.M144T		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	144	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	AGTGCGGCGCATGGTCACGAT	0.582													20	21					0	0	0	0	G	13885087	G	G	13885087	3	3	256	1	0	0	0	0	1	0	0	0	9417	217	8	5	466	5	MC2R	18	13885087	Missense_Mutation	SNP	A	TCGA-CV-7421-01A-11D-2078-08		13885087	64192161	65	46748											
TSHZ1	10194	broad.mit.edu	37	chr18	73000485	73000485	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccacattccaatgtaagctCtgcaaccggacttttgcgag	10	11	8	12	2	1	0	0	0	1	0	3	2	3	1	3	1	4	3	3	1	3	4	rs147097201		TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr18:73000485C>T	uc002lly.2	+	2	3551	c.2988C>T	c.(2986-2988)CTC>CTT	p.L996L		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	1041	C2H2-type 5.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		AATGTAAGCTCTGCAACCGGA	0.527													20	39					0	0	0	0	T	73000485	T	T	73000485	2	4	256	1	0	0	0	0	0	0	0	1	16690	900	32	2		2	TSHZ1	18	73000485	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08	59115398	73000485	5076763	66	46749											
ASNA1	439	broad.mit.edu	37	chr19	12856229	12856229	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgtggcggagctgcctgaCgagttcttcgaggaggacaa	8	7	17	9	4	1	1	0	1	1	0	2	6	1	4	1	5	2	2	1	5	1	2			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr19:12856229C>T	uc002muv.2	+	3	362	c.348C>T	c.(346-348)GAC>GAT	p.D116D	ASNA1_uc002muw.2_Silent_p.D115D	NM_004317	NP_004308	O43681	ASNA_HUMAN	arsA arsenite transporter, ATP-binding, homolog	116					response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding			ovary(2)	2					Adenosine triphosphate(DB00171)	AGCTGCCTGACGAGTTCTTCG	0.612													8	20					0	0	0	0	T	12856229	T	T	12856229	2	4	256	1	0	0	0	0	0	0	0	1	1049	535	19	1		1	ASNA1	19	12856229	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08		12856229	46272754	67	46750											
NCAN	1463	broad.mit.edu	37	chr19	19338829	19338829	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tccccatctgcccccctgggGagccctggagtcttcttggt	3	11	11	16	0	3	0	0	0	3	0	4	2	4	2	6	4	2	0	6	4	0	2			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr19:19338829G>C	uc002nlz.2	+	8	2499	c.2400G>C	c.(2398-2400)GGG>GGC	p.G800G	NCAN_uc010ecc.1_Silent_p.G364G	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	800					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CCCCCCTGGGGAGCCCTGGAG	0.567													11	136					0	0	0	0	C	19338829	C	C	19338829	2	2	256	1	0	0	0	0	0	0	0	1	10258	1161	41	2		2	NCAN	19	19338829	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08	6482600	19338829	39790154	68	46751											
PRKCG	5582	broad.mit.edu	37	chr19	54395868	54395868	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccatgtcctttggcgtctcGgagctgctcaaggcgcccgt	4	10	13	14	4	2	0	1	0	1	0	4	1	3	1	3	3	2	2	3	3	1	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr19:54395868G>A	uc002qcq.1	+	7	1074	c.792G>A	c.(790-792)TCG>TCA	p.S264S	PRKCG_uc010eqz.1_Silent_p.S264S|PRKCG_uc010yef.1_Silent_p.S264S|PRKCG_uc010yeg.1_Silent_p.S264S|PRKCG_uc010yeh.1_Silent_p.S151S	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	264					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TTGGCGTCTCGGAGCTGCTCA	0.642													7	9					0	0	0	0	A	54395868	A	A	54395868	2	1	256	1	0	0	0	0	0	0	0	1	12574	1103	39	1		1	PRKCG	19	54395868	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08	35057039	54395868	4733115	69	46752											
LRRN4	164312	broad.mit.edu	37	chr20	6031559	6031559	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaaatgtccccctccagggtCgtcagccgaggcatcttcct	8	9	9	15	2	2	0	1	0	1	0	6	1	5	0	5	2	1	1	5	2	2	1	rs149005401	byFrequency	TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr20:6031559C>T	uc002wmo.2	-	3	950	c.726G>A	c.(724-726)ACG>ACA	p.T242T	LRRN4_uc002wmp.2_Silent_p.T242T	NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	242	Extracellular (Potential).|LRR 8.					integral to membrane				skin(3)	3						CCTCCAGGGTCGTCAGCCGAG	0.552													10	21					0	0	0	0	T	6031559	T	T	6031559	2	4	256	1	0	0	0	0	0	0	0	1	9087	871	31	1		1	LRRN4	20	6031559	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08		6031559	56993961	70	46753											
XRN2	22803	broad.mit.edu	37	chr20	21328869	21328869	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgcagacatgccatctgAttttgagaagggtacgaaac	13	10	10	8	1	1	3	0	2	1	2	1	5	1	3	1	1	4	2	1	1	3	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr20:21328869A>C	uc002wsf.1	+	18	1846	c.1751A>C	c.(1750-1752)GAT>GCT	p.D584A	XRN2_uc002wsg.1_Missense_Mutation_p.D508A|XRN2_uc010zsk.1_Missense_Mutation_p.D530A	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	584				D -> E (in Ref. 1; AAD55138).	cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						ATGCCATCTGATTTTGAGAAG	0.348													5	49					0	0	0	0	C	21328869	C	C	21328869	3	2	256	1	0	0	0	0	1	0	0	0	17528	333	12	5	1821	5	XRN2	20	21328869	Missense_Mutation	SNP	A	TCGA-CV-7421-01A-11D-2078-08	15297310	21328869	41696651	71	46754											
HM13	81502	broad.mit.edu	37	chr20	30154066	30154066	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggttttcctgtcctggtggcGctggccaagggagaagtgac	6	10	16	9	1	0	2	0	1	0	1	2	3	2	2	3	5	0	2	3	5	2	2			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr20:30154066G>A	uc002wwe.2	+	11	1116	c.1002G>A	c.(1000-1002)GCG>GCA	p.A334A	HM13_uc002wwc.2_Silent_p.A334A|HM13_uc002wwd.2_Silent_p.A334A|HM13_uc002wwf.2_Silent_p.A210A|HM13_uc010gdu.2_Silent_p.A210A	NM_030789	NP_110416	Q8TCT9	HM13_HUMAN	minor histocompatibility antigen 13 isoform 1	334	Helical; (Potential).				membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)	1	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			TCCTGGTGGCGCTGGCCAAGG	0.612													10	107					0	0	0	0	A	30154066	A	A	30154066	2	1	256	1	0	0	0	0	0	0	0	1	7256	1074	38	1		1	HM13	20	30154066	Silent	SNP	G	TCGA-CV-7421-01A-11D-2078-08	8825197	30154066	32871454	72	46755											
NDRG3	57446	broad.mit.edu	37	chr20	35312834	35312834	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accttaggtgggtaagaacaGgaggcagcatttcagccagc	12	7	13	9	0	1	1	1	0	0	1	1	2	1	2	2	4	4	3	2	4	3	3			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr20:35312834G>A	uc002xfw.2	-	6	447	c.365C>T	c.(364-366)CCT>CTT	p.P122L	NDRG3_uc002xfx.2_Missense_Mutation_p.P110L|NDRG3_uc010zvq.1_Missense_Mutation_p.P27L|NDRG3_uc010zvr.1_Missense_Mutation_p.P10L	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	122				P -> S (in Ref. 2; AAK34944).	cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)				GGTAAGAACAGGAGGCAGCAT	0.418													7	38					0	0	0	0	A	35312834	A	A	35312834	3	1	256	1	0	0	0	0	1	0	0	0	10307	1000	35	4	806	4	NDRG3	20	35312834	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	5158768	35312834	27712686	73	46756											
CYYR1	116159	broad.mit.edu	37	chr21	27840862	27840862	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaggagggggtggagaacgCtgtgctggaccctgtggggt	7	8	20	6	1	0	1	0	0	0	1	0	4	0	3	1	7	2	2	1	7	2	1			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr21:27840862C>T	uc002ymd.2	-	4	745	c.423G>A	c.(421-423)CAG>CAA	p.Q141Q	CYYR1_uc011ack.1_RNA|CYYR1_uc002yme.2_Silent_p.Q142Q	NM_052954	NP_443186	Q96J86	CYYR1_HUMAN	cysteine and tyrosine-rich 1 protein precursor	141	Cytoplasmic (Potential).					integral to membrane					0						GTGGAGAACGCTGTGCTGGAC	0.532													5	41					0	0	0	0	T	27840862	T	T	27840862	2	4	256	1	0	0	0	0	0	0	0	1	4228	796	28	4		4	CYYR1	21	27840862	Silent	SNP	C	TCGA-CV-7421-01A-11D-2078-08		27840862	20289033	74	46757											
RWDD2B	10069	broad.mit.edu	37	chr21	30380219	30380219	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttttgcatttgttatagatAtgatggctgtagatccagag	10	16	10	5	0	0	4	0	1	0	3	1	4	1	4	1	1	1	4	1	1	4	7			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr21:30380219A>T	uc002yms.2	-	4	675	c.588T>A	c.(586-588)CAT>CAA	p.H196Q	RWDD2B_uc002ymt.2_Missense_Mutation_p.H167Q|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Missense_Mutation_p.H116Q	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	196											0						TGTTATAGATATGATGGCTGT	0.458													7	59					0	0	0	0	T	30380219	T	T	30380219	3	4	256	1	0	0	0	0	1	0	0	0	13821	446	16	5	379	5	RWDD2B	21	30380219	Missense_Mutation	SNP	A	TCGA-CV-7421-01A-11D-2078-08	2539357	30380219	17749676	75	46758											
SON	6651	broad.mit.edu	37	chr21	34923613	34923613	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acggtagcacaggagctgccTactacattagtgggggagac	11	7	14	9	1	0	1	0	0	0	1	0	3	0	2	1	4	5	3	1	4	4	4			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr21:34923613T>A	uc002yse.1	+	3	2125	c.2076T>A	c.(2074-2076)CCT>CCA	p.P692P	SON_uc002ysb.1_Silent_p.P692P|SON_uc002ysc.2_Silent_p.P692P|SON_uc002ysd.2_Intron|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	692					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						AGGAGCTGCCTACTACATTAG	0.512													16	56					0	0	0	0	A	34923613	A	A	34923613	2	1	256	1	0	0	0	0	0	0	0	1	14990	1509	53	5		5	SON	21	34923613	Silent	SNP	T	TCGA-CV-7421-01A-11D-2078-08	4543394	34923613	13206282	76	46759											
MCM3AP	8888	broad.mit.edu	37	chr21	47704324	47704324	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcgatcctggtcctccttccTtttcagtcctttcattaggc	4	16	7	14	1	2	0	2	0	0	0	7	1	7	0	5	2	0	0	5	2	1	5			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr21:47704324T>C	uc002zir.1	-	1	913	c.877A>G	c.(877-879)AGG>GGG	p.R293G	C21orf57_uc002zit.1_5'Flank|C21orf57_uc002ziu.1_5'Flank|C21orf57_uc002ziv.2_5'Flank|C21orf57_uc002ziw.2_5'Flank|C21orf57_uc002zix.2_5'Flank|C21orf57_uc010gqh.2_5'Flank|C21orf57_uc002ziy.2_5'Flank	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	293					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					TCCTCCTTCCTTTTCAGTCCT	0.572													31	64					0	0	0	0	C	47704324	C	C	47704324	3	2	256	1	0	0	0	0	1	0	0	0	9441	1608	56	5	5177	5	MCM3AP	21	47704324	Missense_Mutation	SNP	T	TCGA-CV-7421-01A-11D-2078-08	12780711	47704324	425571	77	46760											
HIRA	7290	broad.mit.edu	37	chr22	19393354	19393354	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacacaccgccactgctccaCattggcaagcttaccactgg	10	7	8	16	1	0	0	0	0	0	0	1	1	1	0	4	2	3	3	4	2	2	2			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chr22:19393354C>T	uc002zpf.1	-	5	572	c.352G>A	c.(352-354)GTG>ATG	p.V118M	HIRA_uc011agx.1_Translation_Start_Site|HIRA_uc010grn.1_Missense_Mutation_p.V118M|HIRA_uc010gro.1_Missense_Mutation_p.V74M|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	118					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					CACTGCTCCACATTGGCAAGC	0.602													5	32					0	0	0	0	T	19393354	T	T	19393354	3	4	256	1	0	0	0	0	1	0	0	0	7159	478	17	4	2785	4	HIRA	22	19393354	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08		19393354	31911212	78	46761											
MAP7D2	256714	broad.mit.edu	37	chrX	20043130	20043130	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccttctgcagccgggcctGtcttctcttttcagccaaga	5	14	8	14	1	4	1	1	0	3	1	6	1	5	1	4	1	3	1	4	1	1	5			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chrX:20043130G>T	uc004czr.1	-	9	1247	c.1228C>A	c.(1228-1230)CAG>AAG	p.Q410K	MAP7D2_uc004czq.1_Missense_Mutation_p.Q295K|MAP7D2_uc011mji.1_Missense_Mutation_p.Q358K|MAP7D2_uc010nfo.1_Missense_Mutation_p.Q451K|MAP7D2_uc011mjj.1_Missense_Mutation_p.Q365K	NM_152780	NP_689993	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	410										ovary(2)|breast(1)	3						AGCCGGGCCTGTCTTCTCTTT	0.527													56	44					3.40343e-31	8.54814e-31	1	0	T	20043130	T	T	20043130	3	4	256	1	0	0	0	0	1	0	0	0	9321	1386	48	4	998	4	MAP7D2	23	20043130	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08		20043130	135227430	79	46762											
BCOR	54880	broad.mit.edu	37	chrX	39937101	39937101	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgggcgcattcacctgtCttcgctcgccccacacatgc	7	9	9	16	3	2	1	1	0	1	1	4	1	2	1	3	1	1	2	3	1	0	2			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chrX:39937101C>G	uc004den.3	-	2	374	c.82G>C	c.(82-84)GAC>CAC	p.D28H	BCOR_uc004dep.3_Missense_Mutation_p.D28H|BCOR_uc004deo.3_Missense_Mutation_p.D28H|BCOR_uc004dem.3_Missense_Mutation_p.D28H|BCOR_uc004deq.3_Missense_Mutation_p.D28H	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	28					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						ATTCACCTGTCTTCGCTCGCC	0.627													18	9					0	0	0	0	G	39937101	G	G	39937101	3	3	256	1	0	0	0	0	1	0	0	0	1388	913	32	2	5241	2	BCOR	23	39937101	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08	19893971	39937101	115333459	80	46763											
AR	367	broad.mit.edu	37	chrX	66765243	66765245	+	In_Frame_Del	DEL	GCA	-	-																															cagcaagagactagccccagGcagcagcagcagcagcaggg																										TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chrX:66765243_66765245delGCA	uc004dwu.1	+	1	1370_1372	c.255_257delGCA	c.(253-258)AGGCAG>AGG	p.Q91del	AR_uc011mpd.1_In_Frame_Del_p.Q91del|AR_uc011mpe.1_RNA|AR_uc011mpf.1_In_Frame_Del_p.Q91del	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	89	Poly-Gln.|Modulating.|Gln-rich.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	ctagccccaggcagcagcagcag	0.296									Androgen_Insensitivity_Syndrome				---	---	---								-	66765245	-	-	66765243	7	5	256	1	0	1	0	1	0	0	0	0	836	1194	42	0	257	0	AR	23	66765243	In_Frame_Del	DEL	GCA	TCGA-CV-7421-01A-11D-2078-08	26828142	66765243	88505317	81	46764											
TMEM187	8269	broad.mit.edu	37	chrX	153247560	153247560	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgtgcacgtggccgtggccgGtggcctctgtgccgtggctg	1	9	18	13	5	1	0	0	0	1	0	1	0	1	0	4	5	2	2	4	5	0	0			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chrX:153247560G>C	uc004fjq.2	+	2	581	c.47G>C	c.(46-48)GGT>GCT	p.G16A	hsa-mir-3202-2|MI0014253_5'Flank	NM_003492	NP_003483	Q14656	TM187_HUMAN	transmembrane protein 187	16	Helical; (Potential).					integral to membrane|transport vesicle					0	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCGTGGCCGGTGGCCTCTGT	0.647													14	10					0	0	0	0	C	153247560	C	C	153247560	3	2	256	1	0	0	0	0	1	0	0	0	16175	1261	44	4	49	4	TMEM187	23	153247560	Missense_Mutation	SNP	G	TCGA-CV-7421-01A-11D-2078-08	86482317	153247560	2023000	82	46765											
RPL10	6134	broad.mit.edu	37	chrX	153628946	153628946	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccctgcgcagggccaagttCaagtttcctggccgccagaa	8	7	12	14	2	1	1	1	0	0	1	2	1	2	1	5	2	1	3	5	2	3	2			TCGA-CV-7421-01A-11D-2078-08	TCGA-CV-7421-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee675976-b447-48c8-bc67-6878a0d35e07	7da18a81-556e-48ca-a591-d8db35d19aad	g.chrX:153628946C>G	uc004fkm.2	+	6	659	c.471C>G	c.(469-471)TTC>TTG	p.F157L	uc010nuv.1_5'Flank|RPL10_uc004fko.2_Intron|RPL10_uc004fkn.1_Missense_Mutation_p.F157L|RPL10_uc004fkp.1_3'UTR|RPL10_uc004fkq.1_Intron|RPL10_uc004fkr.1_Missense_Mutation_p.F82L	NM_006013	NP_006004	P27635	RL10_HUMAN	ribosomal protein L10	157				F -> L (in Ref. 8; BAD97029).	endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGCCAAGTTCAAGTTTCCTG	0.562													3	35					0	0	0	0	G	153628946	G	G	153628946	3	3	256	1	0	0	0	0	1	0	0	0	13619	825	29	2	489	2	RPL10	23	153628946	Missense_Mutation	SNP	C	TCGA-CV-7421-01A-11D-2078-08	381386	153628946	1641614	83	46766											
ACAP3	116983	broad.mit.edu	37	chr1	1236026	1236026	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggacagctccaggtcctcccGcaccttgtcaaactgcttct	7	10	8	16	1	2	0	1	0	1	0	5	1	5	1	4	2	3	3	4	2	1	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:1236026G>A	uc001aeb.2	-	6	459	c.385C>T	c.(385-387)CGG>TGG	p.R129W	ACAP3_uc001ady.2_5'Flank|ACAP3_uc001aea.2_Missense_Mutation_p.R87W|ACAP3_uc001aec.1_Missense_Mutation_p.R87W	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	129					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						AGGTCCTCCCGCACCTTGTCA	0.647													11	45					0	0	0	0	A	1236026	A	A	1236026	3	1	257	1	0	0	0	0	1	0	0	0	120	1086	38	1	2195	1	ACAP3	1	1236026	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08		1236026	248014595	1	46767											
UBE4B	10277	broad.mit.edu	37	chr1	10132157	10132157	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accaccccactcacctctccCcagagggagaaccctccggg	9	4	8	20	1	2	2	1	0	1	2	4	3	3	2	8	2	1	0	8	2	1	0			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:10132157C>A	uc001aqs.3	+	2	809	c.96C>A	c.(94-96)CCC>CCA	p.P32P	UBE4B_uc001aqr.3_Silent_p.P32P|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_5'UTR	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	32					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TCACCTCTCCCCAGAGGGAGA	0.597													17	47					1.33834e-09	1.58618e-09	1	0	A	10132157	A	A	10132157	2	1	257	1	0	0	0	0	0	0	0	1	16951	610	22	4		4	UBE4B	1	10132157	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	8896131	10132157	239118464	2	46768											
ARID1A	8289	broad.mit.edu	37	chr1	27106228	27106228	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catttggcattagcccagcaCagagccaccggaacatcaag	13	6	9	13	1	1	1	1	0	0	1	1	2	1	2	3	2	4	2	3	2	3	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:27106228C>T	uc001bmv.1	+	20	6212	c.5839C>T	c.(5839-5841)CAG>TAG	p.Q1947*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1730*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q793*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.Q275*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.Q189*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1947					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TAGCCCAGCACAGAGCCACCG	0.532			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								18	73					0	0	0	0	T	27106228	T	T	27106228	4	4	257	1	0	0	0	0	0	1	0	0	913	479	17	4	5917	4	ARID1A	1	27106228	Nonsense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	16974071	27106228	222144393	3	46769											
EPHA10	284656	broad.mit.edu	37	chr1	38227731	38227731	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggatgggacggtcgtgttCatccacgccgctgatctcct	5	10	13	13	5	2	1	1	1	1	0	5	3	3	3	3	3	0	2	3	3	0	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:38227731C>G	uc009vvi.2	-	3	282	c.196G>C	c.(196-198)GAA>CAA	p.E66Q	EPHA10_uc001cbw.3_Missense_Mutation_p.E66Q	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	66	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CGGTCGTGTTCATCCACGCCG	0.617													8	56					0	0	0	0	G	38227731	G	G	38227731	3	3	257	1	0	0	0	0	1	0	0	0	5190	835	29	2	2928	2	EPHA10	1	38227731	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	11121503	38227731	211022890	4	46770											
MACF1	23499	broad.mit.edu	37	chr1	39854051	39854052	+	Nonsense_Mutation	DNP	TG	AT	AT																															aaattagacatagaggcctcTgaagcagagtgtcgacatat																										TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:39854051_39854052TG>AT	uc010oiu.1	+	22	10988_10989	c.10857_10858TG>AT	c.(10855-10860)TCTGAA>TCATAA	p.E3620*	MACF1_uc010ois.1_Nonsense_Mutation_p.E3118*|MACF1_uc001cda.1_Nonsense_Mutation_p.E3005*|MACF1_uc001cdc.1_Nonsense_Mutation_p.E2184*	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	5185	LRR 20.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TAGAGGCCTCTGAAGCAGAGTG	0.47													5	40					0	0	0	0	AT	39854052	AT	AT	39854051	4	1	257	1	0	0	0	0	0	1	0	0	9195	1567	55	5	15712	5	MACF1	1	39854051	Nonsense_Mutation	DNP	TG	TCGA-CV-7422-01A-21D-2078-08	1626320	39854051	209396570	5	46771											
C8B	732	broad.mit.edu	37	chr1	57415426	57415426	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcgtatttgccttgggtCtaaagaagaaaaaagaaagg	17	10	10	4	1	1	3	0	0	1	3	2	3	1	3	1	2	1	1	1	2	9	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:57415426C>A	uc001cyp.2	-	6	734	c.667_splice	c.e6-1	p.T223_splice	C8B_uc010oon.1_Splice_Site_p.T161_splice|C8B_uc010ooo.1_Splice_Site_p.T171_splice	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TGCCTTGGGTCTAAAGAAGAA	0.269													8	26					6.5536e-12	7.96387e-12	1	0	A	57415426	A	A	57415426	5	1	257	1	0	0	0	0	0	0	1	0	2428	927	32	2	1137	2	C8B	1	57415426	Splice_Site	SNP	C	TCGA-CV-7422-01A-21D-2078-08	17561375	57415426	191835195	6	46772											
ZNF644	84146	broad.mit.edu	37	chr1	91406244	91406244	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaccatcctcacccacctCtacttgatttattaaagtgc	10	14	3	14	0	3	1	2	1	1	0	4	1	4	1	4	0	2	0	4	0	4	6			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:91406244C>G	uc001dnw.2	-	3	809	c.667G>C	c.(667-669)GAG>CAG	p.E223Q	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.E223Q	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TCACCCACCTCTACTTGATTT	0.373													35	171					0	0	0	0	G	91406244	G	G	91406244	3	3	257	1	0	0	0	0	1	0	0	0	18127	922	32	2	3332	2	ZNF644	1	91406244	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	33990818	91406244	157844377	7	46773											
VCAM1	7412	broad.mit.edu	37	chr1	101186049	101186049	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagctcaagcttttaaaatcGagaccaccccagaatctaga	15	8	6	12	1	2	3	1	0	1	3	3	4	2	3	3	0	2	2	3	0	5	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:101186049G>C	uc001dti.2	+	2	202	c.82G>C	c.(82-84)GAG>CAG	p.E28Q	VCAM1_uc001dtj.2_Missense_Mutation_p.E28Q|VCAM1_uc010ouj.1_Missense_Mutation_p.E28Q	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	28	Ig-like C2-type 1.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	TTTTAAAATCGAGACCACCCC	0.413													8	111					0	0	0	0	C	101186049	C	C	101186049	3	2	257	1	0	0	0	0	1	0	0	0	17205	1059	37	3	88	3	VCAM1	1	101186049	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	9779805	101186049	148064572	8	46774											
C1orf103	55791	broad.mit.edu	37	chr1	111494331	111494331	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtctgtaacgtgtcttttCttactggagtatcaggagaa	9	15	10	7	1	4	1	1	0	3	1	4	3	4	2	0	2	2	2	0	2	4	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:111494331C>A	uc001eaa.2	-	2	1431	c.1175G>T	c.(1174-1176)AGA>ATA	p.R392I	C1orf103_uc001dzz.2_Intron|C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		CGTGTCTTTTCTTACTGGAGT	0.388													33	237					2.08457e-15	2.56562e-15	1	0	A	111494331	A	A	111494331	3	1	257	1	0	0	0	0	1	0	0	0	1986	913	32	2	1146	2	C1orf103	1	111494331	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	10308282	111494331	137756290	9	46775											
NBPF7	343505	broad.mit.edu	37	chr1	120386968	120386968	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaagccggccatttgagttAcaagaaatttctgcttcatg	11	12	10	8	1	2	2	1	1	1	1	2	3	2	3	2	2	3	2	2	2	4	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:120386968A>G	uc010oxk.1	-	1	812	c.191T>C	c.(190-192)GTA>GCA	p.V64A		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	64						cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		CATTTGAGTTACAAGAAATTT	0.428											OREG0013730	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	70					0	0	0	0	G	120386968	G	G	120386968	3	3	257	1	0	0	0	0	1	0	0	0	10252	391	14	5	1105	5	NBPF7	1	120386968	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08	8892637	120386968	128863653	10	46776											
FLG2	388698	broad.mit.edu	37	chr1	152327955	152327955	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagaactgtgttggccataGctagactgacctgatctaga	11	10	10	10	0	1	5	0	2	1	3	1	5	1	5	3	1	2	2	3	1	4	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:152327955G>A	uc001ezw.3	-	3	2380	c.2307C>T	c.(2305-2307)AGC>AGT	p.S769S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	769	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTGGCCATAGCTAGACTGAC	0.517													23	411					0	0	0	0	A	152327955	A	A	152327955	2	1	257	1	0	0	0	0	0	0	0	1	5955	962	34	4		4	FLG2	1	152327955	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	31940987	152327955	96922666	11	46777											
UBE2Q1	55585	broad.mit.edu	37	chr1	154523418	154523418	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggctccagcctcaccgttTttttcgtggatctgcaccaa	6	13	8	14	2	2	0	1	0	1	0	4	1	3	1	4	2	2	3	4	2	1	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:154523418T>C	uc001fff.1	-	12	1324	c.1233A>G	c.(1231-1233)AAA>AAG	p.K411K		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	411							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCTCACCGTTTTTTTCGTGGA	0.532													49	129					0	0	0	0	C	154523418	C	C	154523418	2	2	257	1	0	0	0	0	0	0	0	1	16937	1838	64	5		5	UBE2Q1	1	154523418	Silent	SNP	T	TCGA-CV-7422-01A-21D-2078-08	2195463	154523418	94727203	12	46778											
SHC1	6464	broad.mit.edu	37	chr1	154938440	154938440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actcatgtcaaacaggtcccGgggtgcactgccattgatag	10	9	11	11	1	2	1	2	1	0	0	3	1	3	1	2	3	3	1	2	3	2	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:154938440G>A	uc001ffv.2	-	10	1587	c.1366C>T	c.(1366-1368)CGG>TGG	p.R456W	SHC1_uc001ffu.2_5'Flank|SHC1_uc001ffz.1_Missense_Mutation_p.R227W|SHC1_uc001ffw.2_Missense_Mutation_p.R457W|SHC1_uc001ffx.2_Missense_Mutation_p.R347W|SHC1_uc001ffy.2_Missense_Mutation_p.R346W	NM_183001	NP_892113	P29353	SHC1_HUMAN	SHC-transforming protein 1 isoform 1	456	Pro-rich.|CH1.				activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(1)|skin(1)	2	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AACAGGTCCCGGGGTGCACTG	0.562													26	91					0	0	0	0	A	154938440	A	A	154938440	3	1	257	1	0	0	0	0	1	0	0	0	14335	1115	39	1	397	1	SHC1	1	154938440	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	415022	154938440	94312181	13	46779											
OR6N1	128372	broad.mit.edu	37	chr1	158735880	158735880	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggaatttataacaaaatctActaggacatttatagacgta	18	12	6	5	1	1	1	0	0	1	1	1	3	1	3	0	2	2	1	0	2	10	9			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:158735880A>G	uc010piq.1	-	1	593	c.593T>C	c.(592-594)GTA>GCA	p.V198A		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AACAAAATCTACTAGGACATT	0.483													10	90					0	0	0	0	G	158735880	G	G	158735880	3	3	257	1	0	0	0	0	1	0	0	0	11260	391	14	5	348	5	OR6N1	1	158735880	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08	3797440	158735880	90514741	14	46780											
CCDC19	25790	broad.mit.edu	37	chr1	159842833	159842833	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctcaaaggtggcaatcCggttctgcacttccttctgc	6	12	8	15	1	3	0	1	0	2	0	6	0	6	0	4	3	2	3	4	3	2	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:159842833C>T	uc001fui.2	-	11	1496	c.1478G>A	c.(1477-1479)CGG>CAG	p.R493Q	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.R408Q|CCDC19_uc001ful.2_Missense_Mutation_p.R408Q	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	493	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			GGTGGCAATCCGGTTCTGCAC	0.597													6	77					0	0	0	0	T	159842833	T	T	159842833	3	4	257	1	0	0	0	0	1	0	0	0	2808	652	23	1	185	1	CCDC19	1	159842833	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	1106953	159842833	89407788	15	46781											
PLA2G4A	5321	broad.mit.edu	37	chr1	186909195	186909195	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttcacctgtcttcatgtCaaacctgacgtttcagagct	8	15	6	12	1	5	2	4	1	1	1	5	2	5	2	2	0	2	2	2	0	1	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:186909195C>T	uc001gsc.2	+	10	1207	c.1002C>T	c.(1000-1002)GTC>GTT	p.V334V	PLA2G4A_uc010pos.1_Silent_p.V274V	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	334	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	GTCTTCATGTCAAACCTGACG	0.418													5	87					0	0	0	0	T	186909195	T	T	186909195	2	4	257	1	0	0	0	0	0	0	0	1	12056	813	29	2		2	PLA2G4A	1	186909195	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	27066362	186909195	62341426	16	46782											
CR1L	1379	broad.mit.edu	37	chr1	207867934	207867934	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctaacaaatgcacgcctccaAatgtggaaaatggaatattg	16	9	8	8	1	0	0	0	0	0	0	1	2	1	2	2	2	2	1	2	2	7	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:207867934A>G	uc001hga.3	+	5	821	c.700A>G	c.(700-702)AAT>GAT	p.N234D	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	234	Sushi 4.					cytoplasm|extracellular region|membrane					0						CACGCCTCCAAATGTGGAAAA	0.473													8	338					0	0	0	0	G	207867934	G	G	207867934	3	3	257	1	0	0	0	0	1	0	0	0	3856	14	1	5	718	5	CR1L	1	207867934	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08	20958739	207867934	41382687	17	46783											
SLC30A10	55532	broad.mit.edu	37	chr1	220088985	220088985	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagccattgacgtgagccaGaggcagtgccccggggggac	9	4	16	12	2	0	3	0	2	0	1	0	4	0	4	4	4	3	1	4	4	0	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:220088985G>C	uc001hlw.2	-	4	1475	c.1264C>G	c.(1264-1266)CTG>GTG	p.L422V	SLC30A10_uc001hlu.1_Intron|SLC30A10_uc001hlv.2_Missense_Mutation_p.L177V|SLC30A10_uc001hlx.2_Missense_Mutation_p.L197V	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),	422	Cytoplasmic (Potential).				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		ACGTGAGCCAGAGGCAGTGCC	0.567													31	61					0	0	0	0	C	220088985	C	C	220088985	3	2	257	1	0	0	0	0	1	0	0	0	14618	933	33	2	197	2	SLC30A10	1	220088985	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	12221051	220088985	29161636	18	46784											
HNRNPU	3192	broad.mit.edu	37	chr1	245019248	245019248	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcatattgaatcctccacGtcctctatggccaccacctc	9	10	5	17	2	1	1	0	1	1	0	5	1	4	1	6	1	0	1	6	1	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr1:245019248G>A	uc001iaz.1	-	11	2343	c.2125C>T	c.(2125-2127)CGT>TGT	p.R709C	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Missense_Mutation_p.R433C|HNRNPU_uc001iba.1_Missense_Mutation_p.R690C	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	709	Gly-rich.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			AATCCTCCACGTCCTCTATGG	0.403													12	206					0	0	0	0	A	245019248	A	A	245019248	3	1	257	1	0	0	0	0	1	0	0	0	7312	1145	40	1	368	1	HNRNPU	1	245019248	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	24930263	245019248	4231373	19	46785											
APOB	338	broad.mit.edu	37	chr2	21233595	21233595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aacaattgtaaattcttgggGcttctcaacggcatctctca	11	13	7	10	1	4	0	2	0	3	0	6	0	4	0	0	3	2	3	0	3	5	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr2:21233595G>A	uc002red.2	-	26	6273	c.6145C>T	c.(6145-6147)CCC>TCC	p.P2049S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2049	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATTCTTGGGGCTTCTCAACG	0.373													11	133					0	0	0	0	A	21233595	A	A	21233595	3	1	257	1	0	0	0	0	1	0	0	0	785	1203	42	4	7562	4	APOB	2	21233595	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08		21233595	221965778	20	46786											
TMEM131	23505	broad.mit.edu	37	chr2	98411468	98411468	+	Nonsense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggcttctgcacaggttgctAacatatggtaaggaagggat	11	10	14	6	0	1	0	0	0	1	0	1	2	1	2	0	5	3	5	0	5	4	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr2:98411468A>C	uc002syh.3	-	29	3540	c.3311T>G	c.(3310-3312)TTA>TGA	p.L1104*		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1104	Helical; (Potential).					integral to membrane				ovary(4)|central_nervous_system(2)	6						ACAGGTTGCTAACATATGGTA	0.403													11	22					0	0	0	0	C	98411468	C	C	98411468	4	2	257	1	0	0	0	0	0	1	0	0	16110	372	13	5	2392	5	TMEM131	2	98411468	Nonsense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08	77177873	98411468	144787905	21	46787											
CCDC138	165055	broad.mit.edu	37	chr2	109463283	109463283	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attcaggataattctccacaGcattctgtggagaataaacc	14	11	7	9	0	3	1	1	0	2	1	4	3	3	2	2	2	2	1	2	2	4	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr2:109463283G>A	uc002ten.1	+	12	1473	c.1413G>A	c.(1411-1413)CAG>CAA	p.Q471Q	CCDC138_uc002teo.1_Silent_p.Q471Q|CCDC138_uc002tep.1_Silent_p.Q155Q|CCDC138_uc010fjm.1_Silent_p.Q155Q	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	471											0						ATTCTCCACAGCATTCTGTGG	0.363													4	69					0	0	0	0	A	109463283	A	A	109463283	2	1	257	1	0	0	0	0	0	0	0	1	2784	962	34	4		4	CCDC138	2	109463283	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	11051815	109463283	133736090	22	46788											
TTN	7273	broad.mit.edu	37	chr2	179592514	179592514	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttaaatggtggtgttcctttTagtattgccttaaattccac	9	18	7	7	0	0	0	0	0	0	0	2	0	2	0	3	2	1	2	3	2	6	8			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr2:179592514T>C	uc010zfg.1	-	65	16283	c.16059A>G	c.(16057-16059)CTA>CTG	p.L5353L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.L2014L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6280							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGTTCCTTTTAGTATTGCCT	0.393													16	157					0	0	0	0	C	179592514	C	C	179592514	2	2	257	1	0	0	0	0	0	0	0	1	16803	1741	61	5		5	TTN	2	179592514	Silent	SNP	T	TCGA-CV-7422-01A-21D-2078-08	70129231	179592514	63606859	23	46789											
TTLL4	9654	broad.mit.edu	37	chr2	219610493	219610493	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaacattgtcaagcagacCattggacggtcccacttcaa	12	8	7	14	1	2	1	2	0	0	1	3	2	3	2	3	2	2	1	3	2	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr2:219610493C>T	uc002viy.2	+	7	2236	c.1866C>T	c.(1864-1866)ACC>ACT	p.T622T	TTLL4_uc010zkl.1_Silent_p.T457T|TTLL4_uc010fvx.2_Silent_p.T622T|TTLL4_uc010zkm.1_5'Flank	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	622	TTL.				protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		TCAAGCAGACCATTGGACGGT	0.512													4	24					0	0	0	0	T	219610493	T	T	219610493	2	4	257	1	0	0	0	0	0	0	0	1	16797	581	21	4		4	TTLL4	2	219610493	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	40017979	219610493	23588880	24	46790											
FGD5	152273	broad.mit.edu	37	chr3	14965561	14965561	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcttcaccccgcttctcGggcagtgccttttcatccgt	3	14	8	16	3	4	0	2	0	2	0	6	0	5	0	4	1	1	2	4	1	0	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:14965561G>A	uc003bzc.2	+	17	4094	c.3984G>A	c.(3982-3984)TCG>TCA	p.S1328S	FGD5_uc011avk.1_Silent_p.S1328S|FGD5_uc003bzd.2_Silent_p.S406S	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1328					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CCCGCTTCTCGGGCAGTGCCT	0.572													8	53					0	0	0	0	A	14965561	A	A	14965561	2	1	257	1	0	0	0	0	0	0	0	1	5868	1103	39	1		1	FGD5	3	14965561	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08		14965561	183056869	25	46791											
TRIM71	131405	broad.mit.edu	37	chr3	32931948	32931948	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagagcaccatcagtgccGtgcagcaggtcctggaggag	9	7	15	10	1	1	1	1	1	0	1	2	4	2	3	3	3	4	3	3	3	0	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:32931948G>A	uc003cff.2	+	4	1315	c.1252G>A	c.(1252-1254)GTG>ATG	p.V418M		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	418	Potential.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						CATCAGTGCCGTGCAGCAGGT	0.597													5	62					0	0	0	0	A	32931948	A	A	32931948	3	1	257	1	0	0	0	0	1	0	0	0	16611	1145	40	1	1266	1	TRIM71	3	32931948	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	17966387	32931948	165090482	26	46792											
SCN10A	6336	broad.mit.edu	37	chr3	38739930	38739930	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgagggcaaagagcagtgtgCggatccccttggccgctcgg	7	7	16	11	3	0	2	0	1	0	1	2	3	1	3	3	4	2	3	3	4	1	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:38739930C>T	uc003ciq.2	-	27	4781	c.4781G>A	c.(4780-4782)CGC>CAC	p.R1594H		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1594	IV.|Helical; Voltage-sensor; Name=S4 of repeat IV; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GAGCAGTGTGCGGATCCCCTT	0.537													8	90					0	0	0	0	T	38739930	T	T	38739930	3	4	257	1	0	0	0	0	1	0	0	0	13977	768	27	1	1093	1	SCN10A	3	38739930	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	5807982	38739930	159282500	27	46793											
HTR1F	3355	broad.mit.edu	37	chr3	88040986	88040986	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagcattccaaaagcttgtgCgatgtcgatgttagttttaa	12	14	9	6	2	0	0	0	0	0	0	2	2	1	0	1	0	3	4	1	0	5	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:88040986C>T	uc003dqr.2	+	2	1245	c.1087C>T	c.(1087-1089)CGA>TGA	p.R363*		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	363	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	AAAGCTTGTGCGATGTCGATG	0.338													13	53					0	0	0	0	T	88040986	T	T	88040986	4	4	257	1	0	0	0	0	0	1	0	0	7479	760	27	1	1089	1	HTR1F	3	88040986	Nonsense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	49301056	88040986	109981444	28	46794											
IMPG2	50939	broad.mit.edu	37	chr3	100962722	100962722	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagattgtggttggaggcAatttggtagactgtgtcaca	9	13	15	4	0	1	2	1	0	0	2	1	4	1	3	0	5	0	3	0	5	2	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:100962722A>G	uc003duq.1	-	13	2656	c.2453T>C	c.(2452-2454)TTG>TCG	p.L818S	IMPG2_uc011bhe.1_Missense_Mutation_p.L681S	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	818	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGTTGGAGGCAATTTGGTAGA	0.448													12	92					0	0	0	0	G	100962722	G	G	100962722	3	3	257	1	0	0	0	0	1	0	0	0	7768	131	5	5	1300	5	IMPG2	3	100962722	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08	12921736	100962722	97059708	29	46795											
MYH15	22989	broad.mit.edu	37	chr3	108195321	108195321	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatcaagcactttaccaactCagaggagttaatgcccatga	14	9	8	10	0	2	2	2	1	0	1	2	4	2	3	2	1	4	2	2	1	4	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:108195321C>T	uc003dxa.1	-	13	1273	c.1216G>A	c.(1216-1218)GAG>AAG	p.E406K		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	406	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TTTACCAACTCAGAGGAGTTA	0.393													6	29					0	0	0	0	T	108195321	T	T	108195321	3	4	257	1	0	0	0	0	1	0	0	0	10087	835	29	2	4744	2	MYH15	3	108195321	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	7232599	108195321	89827109	30	46796											
CASR	846	broad.mit.edu	37	chr3	121980531	121980531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacaattgcagctgatgacGactatgggcggccggggatt	9	8	15	9	3	0	2	0	2	0	0	0	4	0	3	1	4	2	3	1	4	2	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:121980531G>A	uc003eev.3	+	4	1021	c.649G>A	c.(649-651)GAC>AAC	p.D217N	CASR_uc003eew.3_Missense_Mutation_p.D217N	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	217	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AGCTGATGACGACTATGGGCG	0.537													10	127					0	0	0	0	A	121980531	A	A	121980531	3	1	257	1	0	0	0	0	1	0	0	0	2694	1058	37	1	659	1	CASR	3	121980531	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	13785210	121980531	76041899	31	46797											
OSBPL11	114885	broad.mit.edu	37	chr3	125282600	125282600	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgggactgccaccggcttaCtctgatcagttgcaaagggc	8	9	12	12	1	2	1	1	1	1	0	2	2	2	2	2	3	3	3	2	3	2	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:125282600C>G	uc003eic.2	-	7	1693	c.956G>C	c.(955-957)AGT>ACT	p.S319T		NM_022776	NP_073613	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	319					lipid transport		lipid binding			ovary(3)|breast(1)|kidney(1)	5						CACCGGCTTACTCTGATCAGT	0.413													13	67					0	0	0	0	G	125282600	G	G	125282600	3	3	257	1	0	0	0	0	1	0	0	0	11330	565	20	4	1315	4	OSBPL11	3	125282600	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	3302069	125282600	72739830	32	46798											
TOPBP1	11073	broad.mit.edu	37	chr3	133358856	133358856	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttcgtctgctctctttcccGttctagcagtctccaacagc	5	15	6	15	2	4	0	0	0	4	0	8	0	5	0	2	0	4	3	2	0	2	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:133358856G>A	uc003eps.2	-	13	2312	c.2180C>T	c.(2179-2181)ACG>ATG	p.T727M		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	727	BRCT 5.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						TCTCTTTCCCGTTCTAGCAGT	0.363								Other_conserved_DNA_damage_response_genes					10	42					0	0	0	0	A	133358856	A	A	133358856	3	1	257	1	0	0	0	0	1	0	0	0	16436	1145	40	1	2452	1	TOPBP1	3	133358856	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	8076256	133358856	64663574	33	46799											
ATR	545	broad.mit.edu	37	chr3	142274981	142274981	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatcatctttgactttatcTctggggaaaaaaaagaaaaa	18	11	7	5	0	3	2	1	1	2	1	4	4	3	3	0	2	0	0	0	2	8	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:142274981T>C	uc003eux.3	-	10	2201	c.2079A>G	c.(2077-2079)ATA>ATG	p.I693M		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	693					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TGACTTTATCTCTGGGGAAAA	0.338								Other_conserved_DNA_damage_response_genes					9	80					0	0	0	0	C	142274981	C	C	142274981	3	2	257	1	0	0	0	0	1	0	0	0	1206	1565	54	5	6007	5	ATR	3	142274981	Missense_Mutation	SNP	T	TCGA-CV-7422-01A-21D-2078-08	8916125	142274981	55747449	34	46800											
ZIC1	7545	broad.mit.edu	37	chr3	147128491	147128491	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgccgcagctgcacggctacGggcccatgaacgtgaacatg	9	5	13	14	5	0	2	0	2	0	0	0	2	0	2	2	2	5	4	2	2	3	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:147128491G>A	uc003ewe.2	+	1	1311	c.592G>A	c.(592-594)GGG>AGG	p.G198R		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	198					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GCACGGCTACGGGCCCATGAA	0.652													3	57					0	0	0	0	A	147128491	A	A	147128491	3	1	257	1	0	0	0	0	1	0	0	0	17745	1116	39	1	594	1	ZIC1	3	147128491	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	4853510	147128491	50893939	35	46801											
MME	4311	broad.mit.edu	37	chr3	154890356	154890356	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aacctataggccagagtatgCggttaactccattaaaacag	15	9	8	9	1	0	1	0	0	0	1	1	1	1	1	3	2	4	2	3	2	7	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:154890356C>T	uc010hvr.1	+	22	2319	c.2108C>T	c.(2107-2109)GCG>GTG	p.A703V	MME_uc003fab.1_Missense_Mutation_p.A703V|MME_uc003fac.1_Missense_Mutation_p.A703V|MME_uc003fad.1_Missense_Mutation_p.A703V|MME_uc003fae.1_Missense_Mutation_p.A703V	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	703	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CCAGAGTATGCGGTTAACTCC	0.428													13	128					0	0	0	0	T	154890356	T	T	154890356	3	4	257	1	0	0	0	0	1	0	0	0	9698	768	27	1	2190	1	MME	3	154890356	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	7761865	154890356	43132074	36	46802											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			26	47					0	0	0	0	A	178936082	A	A	178936082	3	1	257	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	24045726	178936082	19086348	37	46803											
C3orf59	151963	broad.mit.edu	37	chr3	192516360	192516360	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgctggtggtgctacctcGcctctggagctccagtgtca	5	11	13	12	1	2	0	1	0	1	0	4	2	3	1	3	3	4	3	3	3	1	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr3:192516360G>A	uc011bsp.1	-	2	1612	c.1291C>T	c.(1291-1293)CGA>TGA	p.R431*		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	431											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		GTGCTACCTCGCCTCTGGAGC	0.607													9	119					0	0	0	0	A	192516360	A	A	192516360	4	1	257	1	0	0	0	0	0	1	0	0	2247	1095	38	1	188	1	C3orf59	3	192516360	Nonsense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	13580278	192516360	5506070	38	46804											
NOP14	8602	broad.mit.edu	37	chr4	2954030	2954030	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgaggtgctcctgctctTcctttgccaattctgcctcc	3	15	7	16	0	2	1	0	1	2	0	6	1	6	1	6	1	4	2	6	1	1	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr4:2954030T>C	uc003ggj.1	-	6	914	c.842A>G	c.(841-843)GAA>GGA	p.E281G	C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.E27G|NOP14_uc003ggk.3_Missense_Mutation_p.E281G|NOP14_uc003ggl.2_Missense_Mutation_p.E281G|NOP14_uc010icq.1_RNA	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	281					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						CTCCTGCTCTTCCTTTGCCAA	0.567													17	48					0	0	0	0	C	2954030	C	C	2954030	3	2	257	1	0	0	0	0	1	0	0	0	10590	1783	62	5	1783	5	NOP14	4	2954030	Missense_Mutation	SNP	T	TCGA-CV-7422-01A-21D-2078-08		2954030	188200246	39	46805											
PCDH7	5099	broad.mit.edu	37	chr4	30723146	30723146	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcggccgccaagcagctcctCcggtaccggctggccgagga	6	4	15	16	5	0	0	0	0	0	0	2	2	2	1	6	5	3	4	6	5	2	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr4:30723146C>G	uc003gsk.1	+	1	1110	c.102C>G	c.(100-102)CTC>CTG	p.L34L	PCDH7_uc011bxw.1_Silent_p.L34L|PCDH7_uc011bxx.1_Silent_p.L34L	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	34	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						AGCAGCTCCTCCGGTACCGGC	0.711													8	13					0	0	0	0	G	30723146	G	G	30723146	2	3	257	1	0	0	0	0	0	0	0	1	11570	842	30	2		2	PCDH7	4	30723146	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	27769116	30723146	160431130	40	46806											
GC	2638	broad.mit.edu	37	chr4	72620734	72620734	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttgagtcttcaacatcacaGcattcaccaaggctttttag	11	13	7	10	0	4	1	3	1	1	0	4	1	4	1	1	1	2	3	1	1	3	6			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr4:72620734G>A	uc003hge.2	-	9	1278	c.1125C>T	c.(1123-1125)TGC>TGT	p.C375C	GC_uc003hgd.2_Silent_p.C253C|GC_uc010iie.2_Silent_p.C375C|GC_uc010iif.2_Silent_p.C394C	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	375	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	CAACATCACAGCATTCACCAA	0.338													11	48					0	0	0	0	A	72620734	A	A	72620734	2	1	257	1	0	0	0	0	0	0	0	1	6317	963	34	4		4	GC	4	72620734	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	41897588	72620734	118533542	41	46807											
F11	2160	broad.mit.edu	37	chr4	187208888	187208888	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatacccttagtgaccaacGaagagtgccagaagagatac	16	6	10	9	1	0	5	0	1	0	4	0	7	0	5	3	0	4	0	3	0	6	3	rs142952627		TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr4:187208888G>T	uc003iza.1	+	14	1960	c.1627G>T	c.(1627-1629)GAA>TAA	p.E543*	uc003izb.1_Intron	NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	543	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	AGTGACCAACGAAGAGTGCCA	0.383													8	68					0.000157383	0.000174668	1	0	T	187208888	T	T	187208888	4	4	257	1	0	0	0	0	0	1	0	0	5362	1059	37	3	1677	3	F11	4	187208888	Nonsense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	114588154	187208888	3945388	42	46808											
FAT1	2195	broad.mit.edu	37	chr4	187540153	187540154	+	Frame_Shift_Ins	INS	-	T	T																															caaagtcatttacaatatggINStaagtaacgtgaccataaat																										TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr4:187540153_187540154insT	uc003izf.2	-	10	7774_7775	c.7586_7587insA	c.(7585-7587)TACfs	p.Y2529fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2529	Extracellular (Potential).|Cadherin 23.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTACAATATGGTAAGTAACGTG	0.411										HNSCC(5;0.00058)			---	---	---								T	187540154	T	T	187540153	7	5	257	1	0	1	1	0	0	0	0	0	5721	1256	44	0	6251	0	FAT1	4	187540153	Frame_Shift_Ins	INS	-	TCGA-CV-7422-01A-21D-2078-08	331265	187540153	3614123	43	46809											
LRRC14B	389257	broad.mit.edu	37	chr5	195405	195405	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaatgagcttggtgctttCttgctgcaagctttcaaaac	10	13	9	9	0	2	1	1	1	1	0	2	1	2	1	0	1	7	6	0	1	4	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr5:195405C>T	uc003jal.1	+	2	1510	c.1482C>T	c.(1480-1482)TTC>TTT	p.F494F		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	494										skin(1)	1						TTGGTGCTTTCTTGCTGCAAG	0.473													17	46					0	0	0	0	T	195405	T	T	195405	2	4	257	1	0	0	0	0	0	0	0	1	9019	912	32	2		2	LRRC14B	5	195405	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08		195405	180719855	44	46810											
C5orf22	55322	broad.mit.edu	37	chr5	31532542	31532542	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgctggtctccggcgttacCccaagctcccagtgtgggtg	4	9	14	14	3	1	0	0	0	1	0	3	0	2	0	4	3	2	3	4	3	2	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr5:31532542C>G	uc003jhj.3	+	1	170	c.43C>G	c.(43-45)CCC>GCC	p.P15A	RNASEN_uc003jhh.2_5'Flank|RNASEN_uc003jhg.2_5'Flank|RNASEN_uc003jhi.2_5'Flank|C5orf22_uc011cnw.1_RNA|C5orf22_uc003jhk.3_5'UTR	NM_018356	NP_060826	Q49AR2	CE022_HUMAN	hypothetical protein LOC55322	15										ovary(2)	2						CCGGCGTTACCCCAAGCTCCC	0.632													7	52					0	0	0	0	G	31532542	G	G	31532542	3	3	257	1	0	0	0	0	1	0	0	0	2295	623	22	4	45	4	C5orf22	5	31532542	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	31337137	31532542	149382718	45	46811											
MAP1B	4131	broad.mit.edu	37	chr5	71494067	71494067	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagatttctcccctaaaactGcaaagtccaggacacccgtt	12	9	6	14	1	1	1	0	0	1	1	3	2	2	2	4	1	2	2	4	1	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr5:71494067G>T	uc003kbw.3	+	5	5126	c.4885G>T	c.(4885-4887)GCA>TCA	p.A1629S	MAP1B_uc010iyw.1_Missense_Mutation_p.A1646S|MAP1B_uc010iyx.1_Missense_Mutation_p.A1503S|MAP1B_uc010iyy.1_Missense_Mutation_p.A1503S	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1629						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CCCTAAAACTGCAAAGTCCAG	0.443													7	102					0.00307968	0.00324889	1	0	T	71494067	T	T	71494067	3	4	257	1	0	0	0	0	1	0	0	0	9281	1319	46	4	4903	4	MAP1B	5	71494067	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	39961525	71494067	109421193	46	46812											
IQGAP2	10788	broad.mit.edu	37	chr5	75906864	75906864	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagttgtagctgtagggtaCatcaatgaagctattgatga	12	12	13	4	0	1	3	1	3	0	0	1	4	1	4	0	2	3	6	0	2	6	6			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr5:75906864C>T	uc003kek.2	+	13	1599	c.1377C>T	c.(1375-1377)TAC>TAT	p.Y459Y	IQGAP2_uc010izv.2_Silent_p.Y12Y|IQGAP2_uc011csv.1_Silent_p.Y12Y|IQGAP2_uc003kel.2_Silent_p.Y12Y	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	459					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CTGTAGGGTACATCAATGAAG	0.393													8	57					0	0	0	0	T	75906864	T	T	75906864	2	4	257	1	0	0	0	0	0	0	0	1	7854	489	17	4		4	IQGAP2	5	75906864	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	4412797	75906864	105008396	47	46813											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139921779	139921779	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtctgcttccttcagtccCtgctctcaaaggggaaatcc	8	11	8	14	0	3	0	2	0	2	0	7	1	6	1	3	2	2	2	3	2	2	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr5:139921779C>T	uc003lfs.1	+	34	7716	c.7592C>T	c.(7591-7593)CCT>CTT	p.P2531L	ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.P1287L|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.P676L	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2531						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTTCAGTCCCTGCTCTCAAA	0.453													7	42					0	0	0	0	T	139921779	T	T	139921779	3	4	257	1	0	0	0	0	1	0	0	0	629	681	24	4	7726	4	ANKHD1-EIF4EBP3	5	139921779	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	64014915	139921779	40993481	48	46814											
PCDHA12	56137	broad.mit.edu	37	chr5	140256490	140256490	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgccacatcttcacggtgtCggcatgggacgcggacgcgc	6	7	14	14	6	2	0	1	0	1	0	3	2	2	2	1	4	1	1	1	4	0	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr5:140256490C>T	uc003lic.2	+	1	1560	c.1433C>T	c.(1432-1434)TCG>TTG	p.S478L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.S478L	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	478	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCACGGTGTCGGCATGGGAC	0.657													10	86					0	0	0	0	T	140256490	T	T	140256490	3	4	257	1	0	0	0	0	1	0	0	0	11576	893	31	1	1435	1	PCDHA12	5	140256490	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	334711	140256490	40658770	49	46815											
PCDHGA5	56110	broad.mit.edu	37	chr5	140745472	140745472	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccttcgactatgagcagttGagagacctacagttgtgggt	9	12	12	8	1	0	3	0	2	0	1	2	5	1	3	2	1	2	3	2	1	2	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr5:140745472G>C	uc003lju.1	+	1	1575	c.1575G>C	c.(1573-1575)TTG>TTC	p.L525F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.L525F	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	525	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAGCAGTTGAGAGACCTAC	0.527													19	146					0	0	0	0	C	140745472	C	C	140745472	3	2	257	1	0	0	0	0	1	0	0	0	11611	1281	45	2	1577	2	PCDHGA5	5	140745472	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	488982	140745472	40169788	50	46816											
PCDHGB4	8641	broad.mit.edu	37	chr5	140768196	140768196	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcagtcaagacgtatacaggGtgagcctttcagaaaacgtg	13	9	11	8	2	3	3	3	1	0	2	3	3	3	3	1	1	3	1	1	1	5	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr5:140768196G>T	uc003lkc.1	+	1	745	c.745G>T	c.(745-747)GTG>TTG	p.V249L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.V249L	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	249	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTATACAGGGTGAGCCTTTC	0.517													22	137					6.21321e-17	7.74634e-17	1	0	T	140768196	T	T	140768196	3	4	257	1	0	0	0	0	1	0	0	0	11619	1261	44	4	747	4	PCDHGB4	5	140768196	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	22724	140768196	40147064	51	46817											
ODZ2	57451	broad.mit.edu	37	chr5	167645811	167645811	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgggaattccctgaagatcCgtcgggacagcagtggcatg	10	8	14	9	2	0	2	0	1	0	1	3	4	2	4	2	3	1	2	2	3	2	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr5:167645811C>T	uc010jjd.2	+	23	4888	c.4888C>T	c.(4888-4890)CGT>TGT	p.R1630C	ODZ2_uc003lzr.3_Missense_Mutation_p.R1400C|ODZ2_uc003lzt.3_Missense_Mutation_p.R1003C|ODZ2_uc010jje.2_Missense_Mutation_p.R894C	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CCTGAAGATCCGTCGGGACAG	0.507													18	93					0	0	0	0	T	167645811	T	T	167645811	3	4	257	1	0	0	0	0	1	0	0	0	10889	652	23	1	4978	1	ODZ2	5	167645811	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	26877615	167645811	13269449	52	46818											
HIST1H3G	8355	broad.mit.edu	37	chr6	26271479	26271479	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctcgcgcagagccacggtgCcgggacggtagcgatgaggt	7	6	17	11	6	1	2	0	1	1	1	2	4	1	3	2	4	3	2	2	4	1	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr6:26271479C>A	uc003nhi.2	-	1	134	c.134G>T	c.(133-135)GGC>GTC	p.G45V	uc003nhj.2_5'Flank|HIST1H2BI_uc003nhk.2_5'Flank	NM_003534	NP_003525	P68431	H31_HUMAN	H3 histone family, member H	45					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						AGCCACGGTGCCGGGACGGTA	0.642													9	80					0.00010058	0.000112275	1	0	A	26271479	A	A	26271479	3	1	257	1	0	0	0	0	1	0	0	0	7200	739	26	4	280	4	HIST1H3G	6	26271479	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08		26271479	144843588	53	46819											
BTN2A2	10385	broad.mit.edu	37	chr6	26392973	26392973	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccgggtgggcgtcttcctGgactatgaagctggagatgt	6	11	16	8	2	1	2	0	1	1	1	2	4	2	3	2	4	2	1	2	4	2	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr6:26392973G>A	uc003nhq.2	+	8	1436	c.1350G>A	c.(1348-1350)CTG>CTA	p.L450L	BTN2A2_uc011dkg.1_3'UTR|BTN2A2_uc003nhr.2_Silent_p.L334L|BTN2A2_uc011dkh.1_Silent_p.L240L|BTN2A2_uc003nhs.2_Intron|BTN2A2_uc003nht.2_Silent_p.L450L|BTN2A2_uc011dki.1_3'UTR	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	450	B30.2/SPRY.|Cytoplasmic (Potential).				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						GCGTCTTCCTGGACTATGAAG	0.547													10	101					0	0	0	0	A	26392973	A	A	26392973	2	1	257	1	0	0	0	0	0	0	0	1	1566	1335	47	4		4	BTN2A2	6	26392973	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	121494	26392973	144722094	54	46820											
BAI3	577	broad.mit.edu	37	chr6	70071087	70071087	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagaatgatggaaagtgacTatattgtgatgcccagaagt	16	10	11	4	0	0	5	0	3	0	2	0	6	0	6	1	1	1	0	1	1	6	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr6:70071087T>C	uc003pev.3	+	29	4370	c.3922T>C	c.(3922-3924)TAT>CAT	p.Y1308H	BAI3_uc010kak.2_Missense_Mutation_p.Y1308H|BAI3_uc011dxx.1_Missense_Mutation_p.Y514H	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1308	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GGAAAGTGACTATATTGTGAT	0.398													6	50					0	0	0	0	C	70071087	C	C	70071087	3	2	257	1	0	0	0	0	1	0	0	0	1302	1522	53	5	4028	5	BAI3	6	70071087	Missense_Mutation	SNP	T	TCGA-CV-7422-01A-21D-2078-08	43678114	70071087	101043980	55	46821											
DOPEY1	23033	broad.mit.edu	37	chr6	83834483	83834483	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagtaatgactcatctgaatTacagctgaccaatttctgct	12	14	6	9	0	3	3	1	3	2	0	3	3	3	3	1	0	3	3	1	0	5	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr6:83834483T>A	uc003pjs.1	+	13	1660	c.1400T>A	c.(1399-1401)TTA>TAA	p.L467*	DOPEY1_uc011dyy.1_Nonsense_Mutation_p.L458*|DOPEY1_uc010kbl.1_Nonsense_Mutation_p.L458*	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	467					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TCATCTGAATTACAGCTGACC	0.368													13	164					0	0	0	0	A	83834483	A	A	83834483	4	1	257	1	0	0	0	0	0	1	0	0	4729	1764	61	5	1442	5	DOPEY1	6	83834483	Nonsense_Mutation	SNP	T	TCGA-CV-7422-01A-21D-2078-08	13763396	83834483	87280584	56	46822											
RSPH4A	345895	broad.mit.edu	37	chr6	116938023	116938023	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccccgcgggaccagaaacAtcatcacctgctcctgtctc	8	7	9	17	2	3	1	2	0	1	1	5	2	4	2	5	2	2	1	5	2	1	0	rs145831200		TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr6:116938023A>G	uc003pxe.2	+	1	382	c.237A>G	c.(235-237)ACA>ACG	p.T79T	RSPH4A_uc010kee.2_Silent_p.T79T	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	79					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						GACCAGAAACATCATCACCTG	0.657									Kartagener_syndrome				13	57					0	0	0	0	G	116938023	G	G	116938023	2	3	257	1	0	0	0	0	0	0	0	1	13771	204	8	5		5	RSPH4A	6	116938023	Silent	SNP	A	TCGA-CV-7422-01A-21D-2078-08	33103540	116938023	54177044	57	46823											
TMEM200A	114801	broad.mit.edu	37	chr6	130762772	130762772	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagtccttggacttagaccGgggtccctccactctaactg	9	10	9	13	1	1	1	0	0	1	1	4	2	4	2	4	3	1	0	4	3	3	3	rs148429620		TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr6:130762772G>C	uc003qca.2	+	3	2076	c.1205G>C	c.(1204-1206)CGG>CCG	p.R402P	TMEM200A_uc010kfh.2_Missense_Mutation_p.R402P|TMEM200A_uc010kfi.2_Missense_Mutation_p.R402P|TMEM200A_uc003qcb.2_Missense_Mutation_p.R402P	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	402	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GACTTAGACCGGGGTCCCTCC	0.502													7	82					0	0	0	0	C	130762772	C	C	130762772	3	2	257	1	0	0	0	0	1	0	0	0	16189	1116	39	3	1207	3	TMEM200A	6	130762772	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	13824749	130762772	40352295	58	46824											
SYNE1	23345	broad.mit.edu	37	chr6	152631904	152631904	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcccgtcccagttctgccacTtgctgagacattttttctgt	5	16	7	13	1	2	1	0	1	2	1	4	2	4	1	3	0	2	2	3	0	0	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr6:152631904T>C	uc010kiw.2	-	88	17417	c.16815A>G	c.(16813-16815)CAA>CAG	p.Q5605Q	SYNE1_uc010kiv.2_Silent_p.Q129Q|SYNE1_uc003qos.3_Silent_p.Q129Q|SYNE1_uc003qot.3_Silent_p.Q5534Q|SYNE1_uc003qou.3_Silent_p.Q5605Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5605	Spectrin 17.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTTCTGCCACTTGCTGAGACA	0.408										HNSCC(10;0.0054)			15	20					0	0	0	0	C	152631904	C	C	152631904	2	2	257	1	0	0	0	0	0	0	0	1	15511	1606	56	5		5	SYNE1	6	152631904	Silent	SNP	T	TCGA-CV-7422-01A-21D-2078-08	21869132	152631904	18483163	59	46825											
UNC93A	54346	broad.mit.edu	37	chr6	167708122	167708122	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcgagaggctgggctgcaagGggaccatcatcctctccatg	8	8	13	12	1	2	1	1	0	1	1	5	3	3	2	3	4	1	3	3	4	1	0			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr6:167708122G>T	uc003qvq.2	+	2	380	c.205G>T	c.(205-207)GGG>TGG	p.G69W	UNC93A_uc003qvr.2_Missense_Mutation_p.G69W	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	69	Helical; (Potential).					integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GGGCTGCAAGGGGACCATCAT	0.652													14	190					6.72482e-11	8.01967e-11	1	0	T	167708122	T	T	167708122	3	4	257	1	0	0	0	0	1	0	0	0	17064	1232	43	4	211	4	UNC93A	6	167708122	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	15076218	167708122	3406945	60	46826											
NPTX2	4885	broad.mit.edu	37	chr7	98256574	98256574	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgggaggcattccaggacgGagagaagctgggcactgggg	9	5	20	7	1	0	1	0	0	0	1	1	5	1	4	1	7	1	3	1	7	1	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr7:98256574G>A	uc003upl.2	+	4	1163	c.986G>A	c.(985-987)GGA>GAA	p.G329E		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	329	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			TTCCAGGACGGAGAGAAGCTG	0.642													15	44					0	0	0	0	A	98256574	A	A	98256574	3	1	257	1	0	0	0	0	1	0	0	0	10657	1174	41	2	1000	2	NPTX2	7	98256574	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08		98256574	60882089	61	46827											
SLC13A1	6561	broad.mit.edu	37	chr7	122787224	122787224	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gttacttacgtattgaaataCtctgcaaagatcaagttggt	13	14	8	6	1	2	2	1	1	1	1	2	2	2	2	0	1	4	4	0	1	7	6			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr7:122787224C>T	uc003vkm.2	-	7	826	c.801G>A	c.(799-801)GAG>GAA	p.E267E	SLC13A1_uc010lks.2_Silent_p.E143E	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	267						integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	TATTGAAATACTCTGCAAAGA	0.368													4	25					0	0	0	0	T	122787224	T	T	122787224	2	4	257	1	0	0	0	0	0	0	0	1	14456	564	20	4		4	SLC13A1	7	122787224	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	24530650	122787224	36351439	62	46828											
COPG2	26958	broad.mit.edu	37	chr7	130148414	130148414	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagactcaccacatactcatCatcatacccatcctcatctg	13	10	2	16	0	6	1	5	0	1	1	7	1	7	1	3	0	2	0	3	0	3	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr7:130148414C>T	uc003vqh.1	-	11	2326	c.2236G>A	c.(2236-2238)GAT>AAT	p.D746N		NM_012133	NP_036265	Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2	746					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity				0	Melanoma(18;0.0435)					ACATACTCATCATCATACCCA	0.473													3	20					0	0	0	0	T	130148414	T	T	130148414	3	4	257	1	0	0	0	0	1	0	0	0	3747	826	29	2	395	2	COPG2	7	130148414	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	7361190	130148414	28990249	63	46829											
ZFHX4	79776	broad.mit.edu	37	chr8	77766752	77766752	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctctccgttcttggaaaggcCcatggacatgccctacatga	9	10	9	13	1	2	1	0	1	2	0	3	3	2	3	3	3	2	1	3	3	2	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr8:77766752C>G	uc003yav.2	+	10	7847	c.7460C>G	c.(7459-7461)CCC>CGC	p.P2487R	ZFHX4_uc003yau.1_Missense_Mutation_p.P2532R|ZFHX4_uc003yaw.1_Missense_Mutation_p.P2487R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2487						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTGGAAAGGCCCATGGACATG	0.527										HNSCC(33;0.089)			12	98					0	0	0	0	G	77766752	G	G	77766752	3	3	257	1	0	0	0	0	1	0	0	0	17702	623	22	4	7629	4	ZFHX4	8	77766752	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08		77766752	68597270	64	46830											
LRP12	29967	broad.mit.edu	37	chr8	105521200	105521200	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttcgcctgggtttgcccttAtgaaccagctacagttgatt	7	15	9	10	1	0	2	0	2	0	0	1	2	0	2	3	1	4	3	3	1	3	6			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr8:105521200A>G	uc003yma.2	-	3	334	c.239T>C	c.(238-240)ATA>ACA	p.I80T	LRP12_uc003ymb.2_Missense_Mutation_p.I61T|LRP12_uc003ymc.3_Missense_Mutation_p.I61T	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	80	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GTTTGCCCTTATGAACCAGCT	0.368													7	82					0	0	0	0	G	105521200	G	G	105521200	3	3	257	1	0	0	0	0	1	0	0	0	9004	449	16	5	2360	5	LRP12	8	105521200	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08	27754448	105521200	40842822	65	46831											
KLHL9	55958	broad.mit.edu	37	chr9	21333736	21333736	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcatccatttattataccGaggatcaaatctgaaaactg	14	12	6	9	1	2	1	1	1	1	0	3	3	3	2	2	1	3	1	2	1	6	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr9:21333736G>A	uc003zoy.2	-	1	1694	c.1123C>T	c.(1123-1125)CGG>TGG	p.R375W	KLHL9_uc003zow.2_Intron|KLHL9_uc003zox.2_RNA	NM_018847	NP_061335	Q9P2J3	KLHL9_HUMAN	kelch-like 9	375	Kelch 2.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				ovary(3)|skin(1)	4				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		TTATTATACCGAGGATCAAAT	0.383													29	65					0	0	0	0	A	21333736	A	A	21333736	3	1	257	1	0	0	0	0	1	0	0	0	8435	1057	37	1	734	1	KLHL9	9	21333736	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08		21333736	119879695	66	46832											
C9orf79	286234	broad.mit.edu	37	chr9	90500809	90500809	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcacagaatgcacactctgtAccactggataaagcctccac	13	8	6	14	0	2	1	1	0	1	1	3	2	3	2	3	1	3	2	3	1	4	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr9:90500809A>C	uc004app.3	+	4	1442	c.1407A>C	c.(1405-1407)GTA>GTC	p.V469V	C9orf79_uc004apo.1_Silent_p.V281V	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	469						integral to membrane				ovary(3)	3						CACACTCTGTACCACTGGATA	0.443													21	205					0	0	0	0	C	90500809	C	C	90500809	2	2	257	1	0	0	0	0	0	0	0	1	2509	378	14	5		5	C9orf79	9	90500809	Silent	SNP	A	TCGA-CV-7422-01A-21D-2078-08	69167073	90500809	50712622	67	46833											
FBP2	8789	broad.mit.edu	37	chr9	97346868	97346868	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtctactcacctttctataGatggcaaagatggttccgat	10	14	8	9	1	3	2	1	0	2	2	4	3	4	2	2	2	1	2	2	2	4	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr9:97346868G>C	uc004auv.2	-	3	484	c.417C>G	c.(415-417)ATC>ATG	p.I139M		NM_003837	NP_003828	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	139					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)				CCTTTCTATAGATGGCAAAGA	0.423													6	39					0	0	0	0	C	97346868	C	C	97346868	3	2	257	1	0	0	0	0	1	0	0	0	5738	932	33	2	622	2	FBP2	9	97346868	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	6846059	97346868	43866563	68	46834											
ASTN2	23245	broad.mit.edu	37	chr9	119770538	119770538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cactcaccacgaagctgcttCctatgggtgaacggagagac	11	7	11	12	2	1	2	1	1	0	1	2	5	2	3	2	2	3	2	2	2	3	2	rs139435569		TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr9:119770538C>T	uc004bjs.1	-	7	1525	c.1424G>A	c.(1423-1425)GGA>GAA	p.G475E	ASTN2_uc004bjr.1_Missense_Mutation_p.G475E|ASTN2_uc004bjt.1_Missense_Mutation_p.G424E	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	475	Extracellular (Potential).					integral to membrane		p.G424E(1)		skin(4)|ovary(3)|breast(1)|kidney(1)	9						GAAGCTGCTTCCTATGGGTGA	0.498													8	46					0	0	0	0	T	119770538	T	T	119770538	3	4	257	1	0	0	0	0	1	0	0	0	1067	869	30	2	2895	2	ASTN2	9	119770538	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	22423670	119770538	21442893	69	46835											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123201903	123201903	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaaaggtcatttcttcccCatcagaaccattcttgggct	10	13	7	11	0	4	2	2	1	2	1	5	2	5	2	3	2	1	1	3	2	3	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr9:123201903C>T	uc004bkf.2	-	24	3677	c.3496G>A	c.(3496-3498)GGG>AGG	p.G1166R	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.G175R|CDK5RAP2_uc004bke.2_Missense_Mutation_p.G451R|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.G1166R|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.G431R|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.G431R|CDK5RAP2_uc011lya.1_Missense_Mutation_p.G431R|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.G936R|CDK5RAP2_uc004bki.2_Missense_Mutation_p.G933R	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1166	Interaction with MAPRE1.				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						ATTTCTTCCCCATCAGAACCA	0.512											OREG0019438	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	42					0	0	0	0	T	123201903	T	T	123201903	3	4	257	1	0	0	0	0	1	0	0	0	3161	594	21	4	2245	4	CDK5RAP2	9	123201903	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	3431365	123201903	18011528	70	46836											
OR1L4	254973	broad.mit.edu	37	chr9	125486388	125486388	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcatgtacctactcactgcGgtggggaatgtgctcatcat	9	12	10	10	1	4	0	4	0	0	0	4	1	4	1	1	3	4	2	1	3	3	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr9:125486388G>A	uc004bmu.1	+	1	120	c.120G>A	c.(118-120)GCG>GCA	p.A40A		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TACTCACTGCGGTGGGGAATG	0.517													15	145					0	0	0	0	A	125486388	A	A	125486388	2	1	257	1	0	0	0	0	0	0	0	1	11019	1103	39	1		1	OR1L4	9	125486388	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	2284485	125486388	15727043	71	46837											
FBXO18	84893	broad.mit.edu	37	chr10	5958323	5958323	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagactctagaaaacttcttTgcctcggctgacgaagagct	12	10	9	10	2	2	4	0	1	2	3	3	5	2	4	1	1	3	2	1	1	5	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:5958323T>C	uc001iis.2	+	10	1787	c.1692T>C	c.(1690-1692)TTT>TTC	p.F564F	FBXO18_uc001iir.2_Silent_p.F490F|FBXO18_uc009xig.2_Silent_p.F490F|FBXO18_uc001iit.2_Silent_p.F615F	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	564					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						AAAACTTCTTTGCCTCGGCTG	0.468													6	98					0	0	0	0	C	5958323	C	C	5958323	2	2	257	1	0	0	0	0	0	0	0	1	5763	1809	63	5		5	FBXO18	10	5958323	Silent	SNP	T	TCGA-CV-7422-01A-21D-2078-08		5958323	129576424	72	46838											
CUBN	8029	broad.mit.edu	37	chr10	17126316	17126316	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggcattgcagctccacgTgggtgaagttgatttgtatt	7	15	12	7	1	1	2	0	2	1	0	2	2	2	2	1	2	2	5	1	2	2	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:17126316T>A	uc001ioo.2	-	17	2307	c.2255A>T	c.(2254-2256)CAC>CTC	p.H752L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	752	CUB 3.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGCTCCACGTGGGTGAAGTT	0.438													7	62					0	0	0	0	A	17126316	A	A	17126316	3	1	257	1	0	0	0	0	1	0	0	0	4068	1696	59	5	8820	5	CUBN	10	17126316	Missense_Mutation	SNP	T	TCGA-CV-7422-01A-21D-2078-08	11167993	17126316	118408431	73	46839											
KIAA1462	57608	broad.mit.edu	37	chr10	30315990	30315990	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agggacagtgggagccctgcCcccctctctccaccactgtc	6	7	10	18	0	1	0	0	0	1	0	4	2	2	2	6	2	2	0	6	2	0	0			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:30315990C>G	uc001iux.2	-	2	3146	c.3087G>C	c.(3085-3087)GGG>GGC	p.G1029G	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.G891G|KIAA1462_uc009xle.1_Silent_p.G1029G	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1029										ovary(4)	4						GGAGCCCTGCCCCCCTCTCTC	0.587													27	96					0	0	0	0	G	30315990	G	G	30315990	2	3	257	1	0	0	0	0	0	0	0	1	8273	610	22	4		4	KIAA1462	10	30315990	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	13189674	30315990	105218757	74	46840											
ZNF239	8187	broad.mit.edu	37	chr10	44052206	44052206	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaaggttggagctctggCtgaagcccttcccacacttg	7	11	12	11	0	1	2	0	2	1	0	2	3	2	3	2	3	2	3	2	3	2	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:44052206C>A	uc001jaw.3	-	2	1975	c.1322G>T	c.(1321-1323)AGC>ATC	p.S441I	ZNF239_uc001jax.3_Missense_Mutation_p.S441I|ZNF239_uc009xmj.2_Missense_Mutation_p.S441I|ZNF239_uc009xmk.2_Missense_Mutation_p.S441I	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	441	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						GGAGCTCTGGCTGAAGCCCTT	0.502													5	28					0.00116845	0.00124634	1	0	A	44052206	A	A	44052206	3	1	257	1	0	0	0	0	1	0	0	0	17858	797	28	4	58	4	ZNF239	10	44052206	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	13736216	44052206	91482541	75	46841											
BICC1	80114	broad.mit.edu	37	chr10	60461890	60461890	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaaactgaagatcggagcCaaatccaagaaaggtaaatt	19	7	8	7	1	1	3	1	1	0	2	3	4	2	4	2	2	2	1	2	2	8	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:60461890C>A	uc001jki.1	+	3	294	c.294C>A	c.(292-294)GCC>GCA	p.A98A		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	98					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						AGATCGGAGCCAAATCCAAGA	0.373													6	33					0.00116845	0.00124634	1	0	A	60461890	A	A	60461890	2	1	257	1	0	0	0	0	0	0	0	1	1430	581	21	4		4	BICC1	10	60461890	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	16409684	60461890	75072857	76	46842											
LRIT1	26103	broad.mit.edu	37	chr10	85992510	85992510	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	actgtgttctgtggaagtcgGtggctcagtgacaatcaagg	9	11	14	7	1	3	1	2	1	1	0	4	2	3	2	0	4	0	2	0	4	3	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:85992510G>T	uc001kcz.1	-	4	1067	c.1045C>A	c.(1045-1047)CCG>ACG	p.P349T		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	349	Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						GTGGAAGTCGGTGGCTCAGTG	0.567													3	35					0.004672	0.00487513	1	0	T	85992510	T	T	85992510	3	4	257	1	0	0	0	0	1	0	0	0	8997	1261	44	4	830	4	LRIT1	10	85992510	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	25530620	85992510	49542237	77	46843											
ACTA2	59	broad.mit.edu	37	chr10	90707105	90707105	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctctgtgcttcgtcaccCacgtagctgtctttttgtcc	3	17	8	13	2	3	0	1	0	2	0	5	0	4	0	2	0	3	4	2	0	1	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:90707105C>G	uc001kfp.2	-	3	284	c.168G>C	c.(166-168)GTG>GTC	p.V56V	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Silent_p.V11V|ACTA2_uc001kfq.2_Silent_p.V56V|ACTA2_uc010qmz.1_Silent_p.V56V	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	56					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		CTTCGTCACCCACGTAGCTGT	0.473													34	117					0	0	0	0	G	90707105	G	G	90707105	2	3	257	1	0	0	0	0	0	0	0	1	192	581	21	4		4	ACTA2	10	90707105	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	4714595	90707105	44827642	78	46844											
HPS1	3257	broad.mit.edu	37	chr10	100195167	100195167	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tggcaatgaacaggcattctCcaaactgcaggcacaggcag	13	6	11	11	0	1	1	0	1	1	0	2	1	1	1	1	4	3	5	1	4	3	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:100195167C>G	uc010qpf.1	-	5	506	c.260G>C	c.(259-261)GGA>GCA	p.G87A	HPS1_uc001kpi.1_Missense_Mutation_p.G87A|HPS1_uc001kpj.1_Missense_Mutation_p.G27A|HPS1_uc001kpk.1_Intron|HPS1_uc009xwb.2_RNA|HPS1_uc010qph.1_Missense_Mutation_p.G87A|HPS1_uc001kpl.2_Missense_Mutation_p.G87A	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	87					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		CAGGCATTCTCCAAACTGCAG	0.597									Hermansky-Pudlak_syndrome				5	55					0	0	0	0	G	100195167	G	G	100195167	3	3	257	1	0	0	0	0	1	0	0	0	7378	855	30	2	1944	2	HPS1	10	100195167	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	9488062	100195167	35339580	79	46845											
CNNM1	26507	broad.mit.edu	37	chr10	101090475	101090475	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agactgcttcatgctgcgctCagacgcggtgctcgacttcg	6	10	12	13	5	2	2	2	0	0	2	4	3	2	2	0	1	4	4	0	1	0	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:101090475C>G	uc001kpp.3	+	1	1620	c.1331C>G	c.(1330-1332)TCA>TGA	p.S444*	CNNM1_uc009xwe.2_Nonsense_Mutation_p.S444*|CNNM1_uc010qpi.1_Nonsense_Mutation_p.S444*|CNNM1_uc009xwf.2_Nonsense_Mutation_p.S444*	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	444	CBS 1.			S -> P (in Ref. 4; AAH98307).	ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		ATGCTGCGCTCAGACGCGGTG	0.612													8	47					0	0	0	0	G	101090475	G	G	101090475	4	3	257	1	0	0	0	0	0	1	0	0	3627	838	29	2	1333	2	CNNM1	10	101090475	Nonsense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	895308	101090475	34444272	80	46846											
ELOVL3	83401	broad.mit.edu	37	chr10	103989006	103989006	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagccaagaccaagagccaGtgaaggtttggagagaacaa	18	4	12	7	0	0	4	0	1	0	3	0	6	0	5	3	2	3	1	3	2	6	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:103989006G>T	uc001kut.2	+	4	973	c.810G>T	c.(808-810)CAG>CAT	p.Q270H		NM_152310	NP_689523	Q9HB03	ELOV3_HUMAN	elongation of very long chain fatty acids like	270	Di-lysine motif (Potential).				fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			ovary(2)	2		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		CCAAGAGCCAGTGAAGGTTTG	0.493											OREG0020475	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	41					0.004672	0.00487513	1	0	T	103989006	T	T	103989006	3	4	257	1	0	0	0	0	1	0	0	0	5099	1020	36	4	824	4	ELOVL3	10	103989006	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	2898531	103989006	31545741	81	46847											
C10orf79	80217	broad.mit.edu	37	chr10	105967445	105967445	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggcgattcctcttctatCttattaagtacagtcacttg	10	16	6	9	1	4	0	1	0	3	0	5	1	5	0	1	1	1	1	1	1	5	7			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr10:105967445C>A	uc001kxw.2	-	6	989	c.873G>T	c.(871-873)AAG>AAT	p.K291N	C10orf79_uc001kxx.3_Missense_Mutation_p.K291N|C10orf79_uc001kxy.1_Missense_Mutation_p.K291N|C10orf79_uc001kxz.2_Missense_Mutation_p.K291N	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	291											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		CCTCTTCTATCTTATTAAGTA	0.393													13	98					0.00010058	0.000112275	1	0	A	105967445	A	A	105967445	3	1	257	1	0	0	0	0	1	0	0	0	1624	912	32	2	4256	2	C10orf79	10	105967445	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	1978439	105967445	29567302	82	46848											
OR52N1	79473	broad.mit.edu	37	chr11	5809578	5809578	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaagtggaagggataacaaGcatcacacccctaagaaaag	19	4	10	8	0	1	1	1	0	0	1	1	4	1	3	2	2	2	1	2	2	7	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:5809578G>T	uc010qzo.1	-	1	469	c.469C>A	c.(469-471)CTT>ATT	p.L157I	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		GGGATAACAAGCATCACACCC	0.507													9	35					0.000442599	0.000480108	1	0	T	5809578	T	T	5809578	3	4	257	1	0	0	0	0	1	0	0	0	11181	971	34	4	496	4	OR52N1	11	5809578	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08		5809578	129196938	83	46849											
OR10A2	341276	broad.mit.edu	37	chr11	6891559	6891559	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgccatcgtcggaaccattCtggtggtcatgatcccctgc	7	10	10	14	3	2	1	1	1	1	0	5	2	3	2	4	3	2	0	4	3	1	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:6891559C>G	uc001meu.1	+	1	574	c.574C>G	c.(574-576)CTG>GTG	p.L192V		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	192	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CGGAACCATTCTGGTGGTCAT	0.502													20	106					0	0	0	0	G	6891559	G	G	6891559	3	3	257	1	0	0	0	0	1	0	0	0	10944	912	32	2	576	2	OR10A2	11	6891559	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	1081981	6891559	128114957	84	46850											
CALCA	796	broad.mit.edu	37	chr11	14989343	14989343	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgatctgctcagcaagccTgccagccgatgagtcacaca	10	7	9	15	1	3	2	2	2	1	0	3	3	3	2	4	0	5	2	4	0	1	0			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:14989343T>G	uc001mlt.1	-	4	360	c.285A>C	c.(283-285)GCA>GCC	p.A95A	CALCA_uc001mlu.1_RNA	NM_001033953	NP_001029125	P06881	CALCA_HUMAN	calcitonin isoform CGRP preproprotein	95					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)	1					Phentolamine(DB00692)	TCAGCAAGCCTGCCAGCCGAT	0.542													10	75					0	0	0	0	G	14989343	G	G	14989343	2	3	257	1	0	0	0	0	0	0	0	1	2587	1567	55	5		5	CALCA	11	14989343	Silent	SNP	T	TCGA-CV-7422-01A-21D-2078-08	8097784	14989343	120017173	85	46851											
OR4C12	283093	broad.mit.edu	37	chr11	50003965	50003965	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccaaaaatactacaaacgTgactttctccattatggggt	15	11	6	9	1	1	1	0	1	1	0	2	1	1	1	2	2	4	0	2	2	7	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:50003965T>G	uc010ria.1	-	1	73	c.73A>C	c.(73-75)ACG>CCG	p.T25P		NM_001005270	NP_001005270	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C,	25	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ACTACAAACGTGACTTTCTCC	0.408													6	54					0	0	0	0	G	50003965	G	G	50003965	3	3	257	1	0	0	0	0	1	0	0	0	11100	1696	59	5	860	5	OR4C12	11	50003965	Missense_Mutation	SNP	T	TCGA-CV-7422-01A-21D-2078-08	35014622	50003965	85002551	86	46852											
NPAS4	266743	broad.mit.edu	37	chr11	66191816	66191816	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatccactaactagcccactGcaaggccagttgactgaaac	13	7	8	13	0	0	2	0	2	0	0	1	3	1	2	3	1	4	2	3	1	4	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:66191816G>A	uc001ohx.1	+	7	1631	c.1455G>A	c.(1453-1455)CTG>CTA	p.L485L	NPAS4_uc010rpc.1_Silent_p.L275L	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	485					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CTAGCCCACTGCAAGGCCAGT	0.557													136	217					0	0	0	0	A	66191816	A	A	66191816	2	1	257	1	0	0	0	0	0	0	0	1	10619	1306	46	4		4	NPAS4	11	66191816	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	16187851	66191816	68814700	87	46853											
PC	5091	broad.mit.edu	37	chr11	66638327	66638327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	attcccaaaggcggccagagCctctgagtaggcccgggtgt	8	7	14	12	2	1	2	0	1	1	1	2	2	2	2	4	4	1	1	4	4	2	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:66638327C>T	uc001ojn.1	-	6	719	c.670G>A	c.(670-672)GCT>ACT	p.A224T	PC_uc001ojo.1_Missense_Mutation_p.A224T|PC_uc001ojp.1_Missense_Mutation_p.A224T	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	224	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GCGGCCAGAGCCTCTGAGTAG	0.637													35	214					0	0	0	0	T	66638327	T	T	66638327	3	4	257	1	0	0	0	0	1	0	0	0	11551	739	26	4	2930	4	PC	11	66638327	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	446511	66638327	68368189	88	46854											
PPFIA1	8500	broad.mit.edu	37	chr11	70224267	70224267	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgacttcttctatgtcttcCccctctatgcagccaaagaa	9	13	6	13	0	4	2	0	1	4	1	5	2	5	2	3	0	2	1	3	0	4	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:70224267C>T	uc001opo.2	+	26	3714	c.3516C>T	c.(3514-3516)TCC>TCT	p.S1172S	PPFIA1_uc001opn.1_Silent_p.S1172S|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opr.2_Silent_p.S311S|PPFIA1_uc001ops.2_Silent_p.S211S|uc001opt.1_Intron	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	1172					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CTATGTCTTCCCCCTCTATGC	0.488													20	215					0	0	0	0	T	70224267	T	T	70224267	2	4	257	1	0	0	0	0	0	0	0	1	12364	610	22	4		4	PPFIA1	11	70224267	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	3585940	70224267	64782249	89	46855											
PAK1	5058	broad.mit.edu	37	chr11	77066805	77066805	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catctggtggagtggtgttaTtttcagtaggtgaaatggga	9	14	15	3	0	2	1	1	1	1	0	2	3	2	3	0	5	0	2	0	5	3	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:77066805T>C	uc001oyh.3	-	7	1213	c.680A>G	c.(679-681)AAT>AGT	p.N227S	PAK1_uc010rso.1_Missense_Mutation_p.N129S|PAK1_uc001oyg.3_Missense_Mutation_p.N227S|PAK1_uc001oyi.1_Missense_Mutation_p.N227S|PAK1_uc010rsn.1_Intron	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2	227	Interaction with CRIPAK.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					AGTGGTGTTATTTTCAGTAGG	0.443													36	69					0	0	0	0	C	77066805	C	C	77066805	3	2	257	1	0	0	0	0	1	0	0	0	11453	1493	52	5	1046	5	PAK1	11	77066805	Missense_Mutation	SNP	T	TCGA-CV-7422-01A-21D-2078-08	6842538	77066805	57939711	90	46856											
PANX1	24145	broad.mit.edu	37	chr11	93911630	93911630	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcatatttgctcagacttGaagtttatcatggaagaact	12	14	7	8	0	3	3	3	1	0	2	3	4	3	4	1	1	2	2	1	1	5	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:93911630G>C	uc001per.2	+	3	802	c.417G>C	c.(415-417)TTG>TTC	p.L139F	PANX1_uc001peq.2_Missense_Mutation_p.L139F	NM_015368	NP_056183	Q96RD7	PANX1_HUMAN	pannexin 1	139	Cytoplasmic (Potential).				positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCTCAGACTTGAAGTTTATCA	0.493													9	42					0	0	0	0	C	93911630	C	C	93911630	3	2	257	1	0	0	0	0	1	0	0	0	11474	1281	45	2	427	2	PANX1	11	93911630	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	16844825	93911630	41094886	91	46857											
BSX	390259	broad.mit.edu	37	chr11	122848470	122848470	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcagccgagcctcggcggCggtggcggcctctgaaccgc	4	5	16	16	6	2	1	1	1	1	0	3	2	2	1	4	5	3	1	4	5	1	0			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:122848470C>T	uc010rzs.1	-	3	589	c.589G>A	c.(589-591)GCC>ACC	p.A197T		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	197											0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		GCCTCGGCGGCGGTGGCGGCC	0.672													3	27					0	0	0	0	T	122848470	T	T	122848470	3	4	257	1	0	0	0	0	1	0	0	0	1540	768	27	1	115	1	BSX	11	122848470	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	28936840	122848470	12158046	92	46858											
ETS1	2113	broad.mit.edu	37	chr11	128354827	128354827	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagggtctcggagaatgacCgaggggtagtcattctcata	11	9	14	7	2	3	3	2	1	2	2	5	5	3	3	1	4	0	1	1	4	3	3	rs142070153	byFrequency	TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr11:128354827C>G	uc010sbs.1	-	5	937	c.621G>C	c.(619-621)TCG>TCC	p.S207S	ETS1_uc001qej.2_Silent_p.S251S|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Silent_p.S207S	NM_005238	NP_005229	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	207					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		GGAGAATGACCGAGGGGTAGT	0.517													27	55					0	0	0	0	G	128354827	G	G	128354827	2	3	257	1	0	0	0	0	0	0	0	1	5299	639	23	3		3	ETS1	11	128354827	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	5506357	128354827	6651689	93	46859											
TAPBPL	55080	broad.mit.edu	37	chr12	6566666	6566666	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctccatggcaccgggcttGgacctcatcagtgtggagtg	6	11	13	11	1	3	0	2	0	1	0	4	2	3	2	3	4	0	2	3	4	0	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:6566666G>C	uc001qog.3	+	4	898	c.660G>C	c.(658-660)TTG>TTC	p.L220F	TAPBPL_uc001qoh.3_Missense_Mutation_p.L78F|TAPBPL_uc001qoi.1_RNA	NM_018009	NP_060479	Q9BX59	TPSNR_HUMAN	TAP binding protein-like precursor	220	Lumenal (Potential).|Ig-like V-type.				antigen processing and presentation of endogenous peptide antigen via MHC class I	endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane					0						CACCGGGCTTGGACCTCATCA	0.622													12	74					0	0	0	0	C	6566666	C	C	6566666	3	2	257	1	0	0	0	0	1	0	0	0	15619	1339	47	4	674	4	TAPBPL	12	6566666	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08		6566666	127285229	94	46860											
PLCZ1	89869	broad.mit.edu	37	chr12	18847863	18847863	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccttattgtaagtgtaattGgcataccctcttttatgtta	9	18	6	8	0	1	0	0	0	1	0	1	0	1	0	2	1	1	4	2	1	6	9			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:18847863G>T	uc010sid.1	-	12	1633	c.1442C>A	c.(1441-1443)CCA>CAA	p.P481Q	PLCZ1_uc001rdv.3_Missense_Mutation_p.P377Q|PLCZ1_uc001rdw.3_Missense_Mutation_p.P222Q|PLCZ1_uc001rdu.1_Missense_Mutation_p.P263Q|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	481	C2.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AAGTGTAATTGGCATACCCTC	0.269													4	38					1.23904e-05	1.39939e-05	1	0	T	18847863	T	T	18847863	3	4	257	1	0	0	0	0	1	0	0	0	12099	1348	47	4	400	4	PLCZ1	12	18847863	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	12281197	18847863	115004032	95	46861											
MLL2	8085	broad.mit.edu	37	chr12	49443617	49443617	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtagggagccctcatctcGggctggactaacatccgtag	8	8	12	13	3	2	0	1	0	1	0	4	2	3	2	3	3	2	3	3	3	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:49443617G>A	uc001rta.3	-	11	3754	c.3754C>T	c.(3754-3756)CGA>TGA	p.R1252*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1252					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCCTCATCTCGGGCTGGACTA	0.597			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			24	96					0	0	0	0	A	49443617	A	A	49443617	4	1	257	1	0	0	0	0	0	1	0	0	9674	1124	39	1	13035	1	MLL2	12	49443617	Nonsense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	30595754	49443617	84408278	96	46862											
KRT71	112802	broad.mit.edu	37	chr12	52938396	52938396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtaatcgttggcactgccccGgctcctgccctccccgcctc	3	9	9	20	3	0	0	0	0	0	0	4	0	2	0	7	2	2	4	7	2	1	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:52938396G>A	uc001sao.2	-	9	1562	c.1492C>T	c.(1492-1494)CGG>TGG	p.R498W		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	498	Tail.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		GCACTGCCCCGGCTCCTGCCC	0.622													32	105					0	0	0	0	A	52938396	A	A	52938396	3	1	257	1	0	0	0	0	1	0	0	0	8523	1115	39	1	83	1	KRT71	12	52938396	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	3494779	52938396	80913499	97	46863											
RNF41	10193	broad.mit.edu	37	chr12	56604300	56604300	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggacatgtctgttgctgaGagaaccactgggtgatgcag	9	10	14	8	0	1	3	0	2	1	1	1	5	1	4	1	2	3	3	1	2	1	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:56604300G>A	uc001skf.1	-	4	512	c.143C>T	c.(142-144)TCT>TTT	p.S48F	RNF41_uc001ske.1_5'UTR|RNF41_uc001skg.1_Missense_Mutation_p.S48F|RNF41_uc010sqg.1_5'UTR|RNF41_uc010sqh.1_5'UTR|RNF41_uc001skh.2_Missense_Mutation_p.S61F	NM_005785	NP_005776	Q9H4P4	RNF41_HUMAN	ring finger protein 41 isoform 1	48	RING-type; degenerate.				apoptosis|induction of apoptosis|protein polyubiquitination|regulation of reactive oxygen species metabolic process		protein binding|protein tag|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1						CTGTTGCTGAGAGAACCACTG	0.532													12	38					0	0	0	0	A	56604300	A	A	56604300	3	1	257	1	0	0	0	0	1	0	0	0	13559	942	33	2	826	2	RNF41	12	56604300	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	3665904	56604300	77247595	98	46864											
GPR182	11318	broad.mit.edu	37	chr12	57389441	57389441	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcctggtgtgcctcagtgtcGaccgctatgtcaccctcacc	5	11	9	16	2	3	0	3	0	0	0	5	1	4	0	5	1	1	1	5	1	1	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:57389441G>A	uc001smk.2	+	2	542	c.448G>A	c.(448-450)GAC>AAC	p.D150N	RDH16_uc010sqx.1_Intron	NM_007264	NP_009195	O15218	GP182_HUMAN	G protein-coupled receptor 182	150	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(1)	1						CCTCAGTGTCGACCGCTATGT	0.597													12	71					0	0	0	0	A	57389441	A	A	57389441	3	1	257	1	0	0	0	0	1	0	0	0	6715	1058	37	1	450	1	GPR182	12	57389441	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	785141	57389441	76462454	99	46865											
NXPH4	11247	broad.mit.edu	37	chr12	57619422	57619422	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctggctctgtgccaagccCttcaaagtcatctgtatctt	7	13	8	13	0	5	0	2	0	3	0	5	0	5	0	3	1	2	2	3	1	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:57619422C>A	uc010srf.1	+	2	994	c.819C>A	c.(817-819)CCC>CCA	p.P273P	NXPH4_uc009zpj.2_Silent_p.P79P	NM_007224	NP_009155	O95158	NXPH4_HUMAN	neurexophilin 4 precursor	273	V (Cys-rich).				neuropeptide signaling pathway	extracellular region					0						GTGCCAAGCCCTTCAAAGTCA	0.577													18	49					5.3912e-06	6.12492e-06	1	0	A	57619422	A	A	57619422	2	1	257	1	0	0	0	0	0	0	0	1	10847	668	24	4		4	NXPH4	12	57619422	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	229981	57619422	76232473	100	46866											
TMBIM4	51643	broad.mit.edu	37	chr12	66539718	66539718	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatgaaagcttgcagaataaTatatacatcatagaaagtaa	20	11	6	4	0	1	3	1	1	0	2	1	3	1	3	0	0	3	3	0	0	10	8			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:66539718T>C	uc001stc.2	-	5	443	c.367A>G	c.(367-369)ATT>GTT	p.I123V	LLPH_uc010ssx.1_RNA|TMBIM4_uc001std.2_Missense_Mutation_p.I92V|TMBIM4_uc009zqr.2_Missense_Mutation_p.I170V|TMBIM4_uc001ste.2_RNA|TMBIM4_uc001stf.2_Missense_Mutation_p.I123V|TMBIM4_uc009zqs.2_Missense_Mutation_p.I123V	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	123	Helical; (Potential).					integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)		TGCAGAATAATATATACATCA	0.303													10	41					0	0	0	0	C	66539718	C	C	66539718	3	2	257	1	0	0	0	0	1	0	0	0	16048	1406	49	5	361	5	TMBIM4	12	66539718	Missense_Mutation	SNP	T	TCGA-CV-7422-01A-21D-2078-08	8920296	66539718	67312177	101	46867											
ZFC3H1	196441	broad.mit.edu	37	chr12	72020216	72020216	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagcagaatccaaggattCtgagcactccctgtatatat	14	11	7	9	0	1	2	0	1	1	1	3	3	3	3	2	1	2	3	2	1	7	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:72020216C>A	uc001swo.2	-	22	4500	c.4141G>T	c.(4141-4143)GAA>TAA	p.E1381*		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1381	TPR 1.|HAT 1.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TCCAAGGATTCTGAGCACTCC	0.353													16	54					4.7546e-09	5.56637e-09	1	0	A	72020216	A	A	72020216	4	1	257	1	0	0	0	0	0	1	0	0	17700	922	32	2	1884	2	ZFC3H1	12	72020216	Nonsense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	5480498	72020216	61831679	102	46868											
NAV3	89795	broad.mit.edu	37	chr12	78400890	78400890	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagcttaattccgtcttcCagtggtattccaaaaccagg	12	11	8	10	1	1	0	0	0	1	0	4	1	4	0	4	2	2	2	4	2	5	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:78400890C>G	uc001syp.2	+	8	1745	c.1572C>G	c.(1570-1572)TCC>TCG	p.S524S	NAV3_uc001syo.2_Silent_p.S524S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	524						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TTCCGTCTTCCAGTGGTATTC	0.448										HNSCC(70;0.22)			13	69					0	0	0	0	G	78400890	G	G	78400890	2	3	257	1	0	0	0	0	0	0	0	1	10238	581	21	4		4	NAV3	12	78400890	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	6380674	78400890	55451005	103	46869											
ATP2B1	490	broad.mit.edu	37	chr12	90010659	90010659	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcattttcattatcccactCtggttctggttctcctgctg	5	18	6	12	0	5	0	2	0	3	0	7	0	6	0	2	2	1	3	2	2	1	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:90010659C>T	uc001tbh.2	-	11	2168	c.1987G>A	c.(1987-1989)GAG>AAG	p.E663K	ATP2B1_uc001tbg.2_Missense_Mutation_p.E663K|ATP2B1_uc001tbf.2_Missense_Mutation_p.E333K	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	663	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TTATCCCACTCTGGTTCTGGT	0.428													22	131					0	0	0	0	T	90010659	T	T	90010659	3	4	257	1	0	0	0	0	1	0	0	0	1141	922	32	2	1873	2	ATP2B1	12	90010659	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	11609769	90010659	43841236	104	46870											
C12orf51	283450	broad.mit.edu	37	chr12	112681213	112681213	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaagatgcgtcactcccccGactcgtacggcagctgtcag	9	7	10	15	4	2	1	2	0	0	1	4	2	3	1	2	1	3	3	2	1	2	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:112681213G>A	uc009zwc.2	-	25	3654	c.3636C>T	c.(3634-3636)GTC>GTT	p.V1212V		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TCACTCCCCCGACTCGTACGG	0.547													5	13					0	0	0	0	A	112681213	A	A	112681213	2	1	257	1	0	0	0	0	0	0	0	1	1702	1045	37	1		1	C12orf51	12	112681213	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	22670554	112681213	21170682	105	46871											
UBC	7316	broad.mit.edu	37	chr12	125398024	125398024	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgctttgacgttctcgatGgtgtcactgggctcgacctc	4	15	11	11	3	2	1	1	1	1	0	5	3	2	1	1	2	1	3	1	2	0	3	rs1138413		TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr12:125398024G>A	uc001ugs.3	-	2	742	c.294C>T	c.(292-294)ACC>ACT	p.T98T	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Silent_p.T98T|UBC_uc001ugt.2_Silent_p.T98T|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_5'UTR	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	98	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CGTTCTCGATGGTGTCACTGG	0.562													8	202					0	0	0	0	A	125398024	A	A	125398024	2	1	257	1	0	0	0	0	0	0	0	1	16910	1335	47	4		4	UBC	12	125398024	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	12716811	125398024	8453871	106	46872											
DIS3	22894	broad.mit.edu	37	chr13	73350163	73350163	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaggtatgtaccagattttAtgccttgctgtagcttactt	9	16	9	7	0	0	1	0	0	0	1	0	2	0	1	2	1	5	5	2	1	6	8			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr13:73350163A>C	uc001vix.3	-	5	1096	c.722T>G	c.(721-723)ATA>AGA	p.I241R	DIS3_uc001viy.3_Missense_Mutation_p.I211R|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	241					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		ACCAGATTTTATGCCTTGCTG	0.358										Multiple Myeloma(4;0.011)			10	28					0	0	0	0	C	73350163	C	C	73350163	3	2	257	1	0	0	0	0	1	0	0	0	4557	449	16	5	2222	5	DIS3	13	73350163	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08		73350163	41819715	107	46873											
RNASE12	493901	broad.mit.edu	37	chr14	21058750	21058750	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tatgatcatgtggttgcagtAccttgcaggaacgggaacgt	10	11	13	7	2	1	1	1	1	0	0	1	3	1	3	1	3	5	4	1	3	4	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr14:21058750A>C	uc001vxt.2	-	1	233	c.133T>G	c.(133-135)TAC>GAC	p.Y45D	RNASE11_uc010ahv.2_5'Flank|RNASE11_uc010ahx.2_5'Flank|RNASE11_uc010ahw.2_5'Flank|RNASE11_uc001vxs.2_5'Flank|uc001vxu.1_RNA	NM_001024822	NP_001019993	Q5GAN4	RNS12_HUMAN	ribonuclease, RNase A family, 12 (non-active)	45						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(95;0.00238)		Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.013)		TGGTTGCAGTACCTTGCAGGA	0.443													17	61					0	0	0	0	C	21058750	C	C	21058750	3	2	257	1	0	0	0	0	1	0	0	0	13467	391	14	5	314	5	RNASE12	14	21058750	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08		21058750	86290790	108	46874											
DICER1	23405	broad.mit.edu	37	chr14	95562901	95562901	+	Frame_Shift_Del	DEL	A	-	-																															cccattaacatattatctatAaatctgatatgttcctgatc																										TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr14:95562901delA	uc001ydw.2	-	24	4538	c.4356delT	c.(4354-4356)TTTfs	p.F1452fs	DICER1_uc010avh.1_Frame_Shift_Del_p.F350fs|DICER1_uc001ydv.2_Frame_Shift_Del_p.F1442fs|DICER1_uc001ydx.2_Frame_Shift_Del_p.F1452fs|DICER1_uc001ydy.1_Frame_Shift_Del_p.F304fs	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1452					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TATTATCTATAAATCTGATAT	0.353			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				---	---	---								-	95562901	-	-	95562901	7	5	257	1	0	1	0	1	0	0	0	0	4543	359	13	0	1432	0	DICER1	14	95562901	Frame_Shift_Del	DEL	A	TCGA-CV-7422-01A-21D-2078-08	74504151	95562901	11786639	109	46875											
CYFIP1	23191	broad.mit.edu	37	chr15	22990179	22990179	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccgtggtcatggaggagctGctgaaggtcgtcaagagcct	8	8	16	9	2	2	2	2	1	0	1	3	4	2	4	2	4	3	2	2	4	2	0			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr15:22990179G>C	uc001yus.2	+	24	2903	c.2799G>C	c.(2797-2799)CTG>CTC	p.L933L	CYFIP1_uc001yut.2_Silent_p.L933L|CYFIP1_uc010aya.1_Silent_p.L961L|CYFIP1_uc001yuu.2_Silent_p.L502L|CYFIP1_uc001yuv.2_Silent_p.L127L	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	933					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TGGAGGAGCTGCTGAAGGTCG	0.582													6	69					0	0	0	0	C	22990179	C	C	22990179	2	2	257	1	0	0	0	0	0	0	0	1	4154	1306	46	4		4	CYFIP1	15	22990179	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08		22990179	79541213	110	46876											
HERC2	8924	broad.mit.edu	37	chr15	28459109	28459109	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagtcggggaagtagtcctCtaactgggcctagtgcagac	9	8	15	9	1	1	1	0	0	1	1	3	3	2	3	2	4	2	2	2	4	4	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr15:28459109C>T	uc001zbj.2	-	42	6671	c.6565G>A	c.(6565-6567)GAG>AAG	p.E2189K		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2189					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AAGTAGTCCTCTAACTGGGCC	0.572													4	27					0	0	0	0	T	28459109	T	T	28459109	3	4	257	1	0	0	0	0	1	0	0	0	7097	922	32	2	8147	2	HERC2	15	28459109	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	5468930	28459109	74072283	111	46877											
RYR3	6263	broad.mit.edu	37	chr15	34040341	34040341	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatttatcgctggcctgcGcgagagtccctgaaaaccat	11	9	10	11	3	0	2	0	1	0	1	2	4	1	2	3	1	2	1	3	1	4	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr15:34040341G>T	uc001zhi.2	+	54	8086	c.8016G>T	c.(8014-8016)GCG>GCT	p.A2672A	RYR3_uc010bar.2_Silent_p.A2672A	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2672	3.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCTGGCCTGCGCGAGAGTCCC	0.522													9	63					0.000442599	0.000480108	1	0	T	34040341	T	T	34040341	2	4	257	1	0	0	0	0	0	0	0	1	13835	1074	38	3		3	RYR3	15	34040341	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	5581232	34040341	68491051	112	46878											
C15orf54	400360	broad.mit.edu	37	chr15	39544747	39544747	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatgagttcaacaaagcgTgtgtgcactatattggctga	13	11	10	7	1	1	2	1	2	0	0	1	2	1	2	0	1	4	3	0	1	5	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr15:39544747T>G	uc001zkg.2	+	2	779	c.411T>G	c.(409-411)CGT>CGG	p.R137R		NM_207445	NP_997328	Q8N8G6	CO054_HUMAN	hypothetical protein LOC400360	137											0		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		CAACAAAGCGTGTGTGCACTA	0.473													14	101					0	0	0	0	G	39544747	G	G	39544747	2	3	257	1	0	0	0	0	0	0	0	1	1808	1683	59	5		5	C15orf54	15	39544747	Silent	SNP	T	TCGA-CV-7422-01A-21D-2078-08	5504406	39544747	62986645	113	46879											
ALPK3	57538	broad.mit.edu	37	chr15	85401044	85401044	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagaacaaccacctggtgcaGagtgcacagaccctgctgct	11	6	11	13	0	0	3	0	0	0	3	0	4	0	3	3	1	6	4	3	1	2	0			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr15:85401044G>A	uc002ble.2	+	6	3848	c.3681G>A	c.(3679-3681)CAG>CAA	p.Q1227Q		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1227					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ACCTGGTGCAGAGTGCACAGA	0.672													13	35					0	0	0	0	A	85401044	A	A	85401044	2	1	257	1	0	0	0	0	0	0	0	1	546	933	33	2		2	ALPK3	15	85401044	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	45856297	85401044	17130348	114	46880											
ITGAD	3681	broad.mit.edu	37	chr16	31419085	31419085	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggctgtctctctgctgcAggtgggacacgctttccagg	4	11	13	13	2	2	0	0	0	2	0	5	1	3	1	1	4	2	4	1	4	0	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr16:31419085A>T	uc002ebv.1	+	9	908	c.859_splice	c.e9-2	p.V287_splice	ITGAD_uc010vfl.1_Silent_p.A318A|ITGAD_uc010cap.1_Splice_Site_p.V287_splice|ITGAD_uc002ebw.1_Silent_p.A129A	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor						cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TCTCTGCTGCAGGTGGGACAC	0.622													8	31					0	0	0	0	T	31419085	T	T	31419085	5	4	257	1	0	0	0	0	0	0	1	0	7923	202	7	5	891	5	ITGAD	16	31419085	Splice_Site	SNP	A	TCGA-CV-7422-01A-21D-2078-08		31419085	58935668	115	46881											
NUP93	9688	broad.mit.edu	37	chr16	56865770	56865770	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtagattgtccccagctacgGaaaacaagctccggctgcat	11	8	10	12	2	0	1	0	0	0	1	2	2	2	2	3	2	5	5	3	2	5	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr16:56865770G>T	uc002eka.2	+	11	1223	c.1102G>T	c.(1102-1104)GAA>TAA	p.E368*	NUP93_uc002ekb.2_Nonsense_Mutation_p.E245*|NUP93_uc010vhi.1_Nonsense_Mutation_p.E245*	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	368					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						CCCAGCTACGGAAAACAAGCT	0.493													4	47					0.00909568	0.00943984	1	0	T	56865770	T	T	56865770	4	4	257	1	0	0	0	0	0	1	0	0	10826	1175	41	2	1140	2	NUP93	16	56865770	Nonsense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	25446685	56865770	33488983	116	46882											
TP53	7157	broad.mit.edu	37	chr17	7579377	7579377	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acggaaaccgtagctgccctGgtaggttttctgggaaggga	9	9	15	8	2	1	0	0	0	1	0	1	3	1	3	2	5	3	4	2	5	4	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr17:7579377G>A	uc002gim.2	-	4	504	c.310C>T	c.(310-312)CAG>TAG	p.Q104*	TP53_uc002gig.1_Nonsense_Mutation_p.Q104*|TP53_uc002gih.2_Nonsense_Mutation_p.Q104*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.Q104*|TP53_uc010cni.1_Nonsense_Mutation_p.Q104*|TP53_uc002gij.2_Nonsense_Mutation_p.Q104*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.Q65*|TP53_uc010cnk.1_Nonsense_Mutation_p.Q119*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	104	Interaction with HIPK1 (By similarity).||Interaction with WWOX.		Q -> H (in sporadic cancers; somatic mutation).|Q -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.Q104*(5)|p.G59fs*23(3)|p.Q104fs*19(1)|p.V73fs*9(1)|p.Q104H(1)|p.Y103_Q104>**(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y103_L111>L(1)|p.Y103fs*15(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TAGCTGCCCTGGTAGGTTTTC	0.632		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	57					0	0	0	0	A	7579377	A	A	7579377	4	1	257	1	0	0	0	0	0	1	0	0	16448	1357	47	4	992	4	TP53	17	7579377	Nonsense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08		7579377	73615833	117	46883											
MYH1	4619	broad.mit.edu	37	chr17	10399767	10399767	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctcttcatctggtcaatttCctcatctttttcagcaattt	7	20	3	11	0	7	0	4	0	3	0	9	0	8	0	1	1	1	1	1	1	2	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr17:10399767C>A	uc002gmo.2	-	34	4850	c.4756G>T	c.(4756-4758)GAA>TAA	p.E1586*	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1586	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TGGTCAATTTCCTCATCTTTT	0.453													22	87					4.35082e-09	5.12489e-09	1	0	A	10399767	A	A	10399767	4	1	257	1	0	0	0	0	0	1	0	0	10082	864	30	2	1091	2	MYH1	17	10399767	Nonsense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	2820390	10399767	70795443	118	46884											
DHRS11	79154	broad.mit.edu	37	chr17	34954655	34954655	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccatgaaggagcggaatGtggacgatgggcacatcatt	12	8	14	7	2	1	1	1	1	0	0	2	5	2	4	1	4	1	1	1	4	2	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr17:34954655G>A	uc002hnd.2	+	3	635	c.421G>A	c.(421-423)GTG>ATG	p.V141M		NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase precursor	141						extracellular region	binding|oxidoreductase activity				0						GGAGCGGAATGTGGACGATGG	0.463													12	87					0	0	0	0	A	34954655	A	A	34954655	3	1	257	1	0	0	0	0	1	0	0	0	4509	1377	48	4	431	4	DHRS11	17	34954655	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	24554888	34954655	46240555	119	46885											
KRT37	8688	broad.mit.edu	37	chr17	39577792	39577792	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatctgggccagctctgtGccgtagcggtcctccgcttc	3	11	12	15	3	2	0	0	0	2	0	5	0	4	0	4	2	4	4	4	2	1	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr17:39577792G>A	uc002hwp.1	-	6	1115	c.1068C>T	c.(1066-1068)GGC>GGT	p.G356G	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	356	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				CCAGCTCTGTGCCGTAGCGGT	0.562													22	39					0	0	0	0	A	39577792	A	A	39577792	2	1	257	1	0	0	0	0	0	0	0	1	8513	1306	46	4		4	KRT37	17	39577792	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	4623137	39577792	41617418	120	46886											
HEXIM1	10614	broad.mit.edu	37	chr17	43227248	43227248	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtactccaagcgggccgccGccaaatccgacgacaccagc	10	4	10	17	5	0	0	0	0	0	0	2	2	2	0	6	1	3	1	6	1	3	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr17:43227248G>A	uc002iig.2	+	1	2565	c.691G>A	c.(691-693)GCC>ACC	p.A231T		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	231	Autoinhibitory acidic region; in absence of 7SK snRNA interacts with the basic region preventing interaction with P-TEFb and modulating subcellular localization.				negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						GCGGGCCGCCGCCAAATCCGA	0.622													19	49					0	0	0	0	A	43227248	A	A	43227248	3	1	257	1	0	0	0	0	1	0	0	0	7115	1087	38	1	693	1	HEXIM1	17	43227248	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	3649456	43227248	37967962	121	46887											
CDC27	996	broad.mit.edu	37	chr17	45235606	45235606	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gattcaaagggagaccagagGaaaggatttaaactaaggct	17	7	12	5	0	1	2	1	0	0	2	1	6	1	4	1	4	1	1	1	4	5	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr17:45235606G>A	uc002ild.3	-	5	568	c.441C>T	c.(439-441)TTC>TTT	p.F147F	CDC27_uc002ile.3_Silent_p.F147F|CDC27_uc002ilf.3_Silent_p.F147F|CDC27_uc010wkp.1_Silent_p.F86F|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	147	TPR 2.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						GAGACCAGAGGAAAGGATTTA	0.418													6	54					0	0	0	0	A	45235606	A	A	45235606	2	1	257	1	0	0	0	0	0	0	0	1	3081	1165	41	2		2	CDC27	17	45235606	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	2008358	45235606	35959604	122	46888											
CA10	56934	broad.mit.edu	37	chr17	49710870	49710870	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cttctgggctcggttgtttgGacagtccttcccctgtaaac	5	14	10	12	1	1	0	0	0	1	0	4	1	3	1	3	3	1	4	3	3	2	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr17:49710870G>C	uc002itw.3	-	8	1917	c.931C>G	c.(931-933)CCA>GCA	p.P311A	CA10_uc002itu.3_Missense_Mutation_p.P240A|CA10_uc002itv.3_Missense_Mutation_p.P317A|CA10_uc002itx.3_Missense_Mutation_p.P311A|CA10_uc002ity.3_Missense_Mutation_p.P311A|CA10_uc002itz.2_Missense_Mutation_p.P311A	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	311					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			CGGTTGTTTGGACAGTCCTTC	0.507													16	53					0	0	0	0	C	49710870	C	C	49710870	3	2	257	1	0	0	0	0	1	0	0	0	2523	1174	41	2	63	2	CA10	17	49710870	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	4475264	49710870	31484340	123	46889											
SLC16A6	9120	broad.mit.edu	37	chr17	66268877	66268877	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattgtgataggatggttacAgttgggagaaaactaaagca	15	11	12	3	0	0	2	0	1	0	1	0	4	0	3	0	3	3	3	0	3	7	6			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr17:66268877A>G	uc002jgz.1	-	4	596	c.408T>C	c.(406-408)ACT>ACC	p.T136T	ARSG_uc002jhc.2_Intron|SLC16A6_uc002jha.1_Silent_p.T136T	NM_004694	NP_004685	O15403	MOT7_HUMAN	solute carrier family 16, member 6	136	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity				0	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	GGATGGTTACAGTTGGGAGAA	0.423													10	61					0	0	0	0	G	66268877	G	G	66268877	2	3	257	1	0	0	0	0	0	0	0	1	14477	175	7	5		5	SLC16A6	17	66268877	Silent	SNP	A	TCGA-CV-7422-01A-21D-2078-08	16558007	66268877	14926333	124	46890											
GPR142	350383	broad.mit.edu	37	chr17	72368126	72368126	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacggttgaccgctacactgCcctgtgccaccccctgcacc	6	7	8	20	2	0	1	0	1	0	0	0	1	0	1	6	1	4	3	6	1	1	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr17:72368126C>A	uc010wqy.1	+	4	776	c.776C>A	c.(775-777)GCC>GAC	p.A259D	GPR142_uc010wqx.1_Missense_Mutation_p.A171D	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	259	Cytoplasmic (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CGCTACACTGCCCTGTGCCAC	0.682													4	31					0.00024832	0.000274008	1	0	A	72368126	A	A	72368126	3	1	257	1	0	0	0	0	1	0	0	0	6688	739	26	4	790	4	GPR142	17	72368126	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	6099249	72368126	8827084	125	46891											
ZNF562	54811	broad.mit.edu	37	chr19	9764328	9764328	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattgagaatttcaagatgcAcagcaaggcctggagttaag	14	9	11	7	0	1	2	1	1	0	2	1	4	1	3	1	2	2	3	1	2	4	3	rs61743320		TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:9764328A>G	uc010xks.1	-	6	741	c.578T>C	c.(577-579)GTG>GCG	p.V193A	ZNF562_uc002mly.2_Missense_Mutation_p.V193A|ZNF562_uc002mlx.2_Missense_Mutation_p.V121A|ZNF562_uc010xkt.1_Missense_Mutation_p.V156A|ZNF562_uc010xku.1_Missense_Mutation_p.V124A|ZNF562_uc010xkv.1_Missense_Mutation_p.V192A|ZNF562_uc010xkw.1_Missense_Mutation_p.V77A	NM_001130032	NP_001123504	Q6V9R5	ZN562_HUMAN	zinc finger protein 562 isoform a	193	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCAAGATGCACAGCAAGGCC	0.403													8	65					0	0	0	0	G	9764328	G	G	9764328	3	3	257	1	0	0	0	0	1	0	0	0	18060	159	6	5	706	5	ZNF562	19	9764328	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08		9764328	49364655	126	46892											
CYP4F2	8529	broad.mit.edu	37	chr19	16006374	16006374	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaaactgaggaggggggaGatgggtcccatccagacctt	11	6	14	10	0	0	3	0	1	0	2	2	5	2	4	3	5	1	0	3	5	1	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:16006374G>T	uc002nbs.1	-	3	335	c.285C>A	c.(283-285)ATC>ATA	p.I95I	CYP4F2_uc010xot.1_5'UTR|CYP4F2_uc010xou.1_Intron	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	95					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						GGAGGGGGGAGATGGGTCCCA	0.592													6	170					2.0095e-06	2.31032e-06	1	0	T	16006374	T	T	16006374	2	4	257	1	0	0	0	0	0	0	0	1	4205	932	33	2		2	CYP4F2	19	16006374	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	6242046	16006374	43122609	127	46893											
OR10H4	126541	broad.mit.edu	37	chr19	16060695	16060695	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttagcccaatcattttcaGcctaaggaacaaggagctga	13	9	8	11	0	2	1	2	1	0	0	2	3	2	3	3	2	4	1	3	2	5	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:16060695G>A	uc010xov.1	+	1	878	c.878G>A	c.(877-879)AGC>AAC	p.S293N		NM_001004465	NP_001004465	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H,	293	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						ATCATTTTCAGCCTAAGGAAC	0.448													44	95					0	0	0	0	A	16060695	A	A	16060695	3	1	257	1	0	0	0	0	1	0	0	0	10962	971	34	4	880	4	OR10H4	19	16060695	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	54321	16060695	43068288	128	46894											
ELL	8178	broad.mit.edu	37	chr19	18632829	18632829	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcgctaacccgcccgcacgAcagcccgtagctcctatcct	7	7	8	19	5	0	0	0	0	0	0	3	1	2	0	5	0	3	4	5	0	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:18632829A>G	uc002njh.2	-	1	109	c.37T>C	c.(37-39)TCG>CCG	p.S13P	ELL_uc010ebq.2_5'UTR	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	13					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)		CGCCCGCACGACAGCCCGTAG	0.587			T	MLL	AL								3	33					0	0	0	0	G	18632829	G	G	18632829	3	3	257	1	0	0	0	0	1	0	0	0	5086	275	10	5	1876	5	ELL	19	18632829	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08	2572134	18632829	40496154	129	46895											
WDR62	284403	broad.mit.edu	37	chr19	36593683	36593683	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtggaggcctctgaagctGaagaccacttcttcaaccca	11	8	9	13	1	3	3	1	2	2	1	3	4	3	4	3	2	2	1	3	2	3	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:36593683G>A	uc002odc.2	+	27	3341	c.3250G>A	c.(3250-3252)GAA>AAA	p.E1084K	WDR62_uc002odd.2_Missense_Mutation_p.E1089K	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	1084					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CTCTGAAGCTGAAGACCACTT	0.617													5	36					0	0	0	0	A	36593683	A	A	36593683	3	1	257	1	0	0	0	0	1	0	0	0	17381	1291	45	2	3371	2	WDR62	19	36593683	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	17960854	36593683	22535300	130	46896											
ZNF790	388536	broad.mit.edu	37	chr19	37310699	37310699	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatgttgagtatgatctgAaccagaaataaaggctttcc	13	12	9	7	0	1	5	0	4	1	1	2	5	2	5	2	1	1	3	2	1	5	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:37310699A>G	uc002oew.2	-	5	666	c.547T>C	c.(547-549)TCA>CCA	p.S183P	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	183					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GTATGATCTGAACCAGAAATA	0.348													11	67					0	0	0	0	G	37310699	G	G	37310699	3	3	257	1	0	0	0	0	1	0	0	0	18229	246	9	5	1367	5	ZNF790	19	37310699	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08	717016	37310699	21818284	131	46897											
ZNF569	148266	broad.mit.edu	37	chr19	37904514	37904514	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atttataaggtttttctcctGtatgacttctcatatgaaga	11	18	6	6	0	2	3	1	2	2	1	4	3	2	3	1	1	0	2	1	1	5	8			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:37904514G>T	uc002ogi.2	-	6	1604	c.1046C>A	c.(1045-1047)ACA>AAA	p.T349K	ZNF569_uc002ogh.2_Missense_Mutation_p.T190K|ZNF569_uc002ogj.2_Missense_Mutation_p.T373K	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTTTCTCCTGTATGACTTCT	0.368													11	107					0.000978159	0.00105509	1	0	T	37904514	T	T	37904514	3	4	257	1	0	0	0	0	1	0	0	0	18067	1377	48	4	1018	4	ZNF569	19	37904514	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	593815	37904514	21224469	132	46898											
LGALS4	3960	broad.mit.edu	37	chr19	39292682	39292682	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgggtgatcttcttctcctCggatccccacgagccattca	6	12	9	14	2	4	1	1	1	3	0	7	3	5	2	4	2	1	0	4	2	0	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:39292682C>T	uc002ojg.2	-	9	989	c.775G>A	c.(775-777)GAG>AAG	p.E259K		NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	259	Galectin 2.|Beta-galactoside binding (By similarity).				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			TTCTTCTCCTCGGATCCCCAC	0.567													15	77					0	0	0	0	T	39292682	T	T	39292682	3	4	257	1	0	0	0	0	1	0	0	0	8785	893	31	1	204	1	LGALS4	19	39292682	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	1388168	39292682	19836301	133	46899											
DYRK1B	9149	broad.mit.edu	37	chr19	40318983	40318983	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgaagtccacaatcttgatgGcgctgcgcttggggttgcac	7	10	13	11	3	1	1	0	1	1	0	2	2	2	1	1	3	2	4	1	3	2	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:40318983G>T	uc002omj.2	-	6	1041	c.761C>A	c.(760-762)GCC>GAC	p.A254D	DYRK1B_uc002omi.2_Missense_Mutation_p.A254D|DYRK1B_uc002omk.2_Missense_Mutation_p.A254D	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	254	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			AATCTTGATGGCGCTGCGCTT	0.622													6	31					0.00307968	0.00324889	1	0	T	40318983	T	T	40318983	3	4	257	1	0	0	0	0	1	0	0	0	4877	1203	42	4	1152	4	DYRK1B	19	40318983	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	1026301	40318983	18810000	134	46900											
MEIS3	56917	broad.mit.edu	37	chr19	47909780	47909780	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttcaaactcatccccactGatcctggaagacaaaaaaaa	18	7	5	11	0	2	2	2	1	0	1	4	3	4	3	3	1	1	1	3	1	6	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:47909780G>A	uc002pgu.2	-	12	1529	c.1082C>T	c.(1081-1083)TCA>TTA	p.S361L	MEIS3_uc010xyp.1_RNA|MEIS3_uc002pgo.2_Intron|MEIS3_uc002pgp.2_Missense_Mutation_p.S193L|MEIS3_uc002pgq.2_Missense_Mutation_p.S442L|MEIS3_uc002pgr.2_Missense_Mutation_p.S229L|MEIS3_uc002pgt.2_Missense_Mutation_p.S344L|MEIS3_uc002pgv.2_Missense_Mutation_p.S390L|MEIS3_uc002pgs.2_Missense_Mutation_p.S407L|MEIS3_uc010eld.2_Missense_Mutation_p.S407L	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	361						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		CATCCCCACTGATCCTGGAAG	0.507													12	94					0	0	0	0	A	47909780	A	A	47909780	3	1	257	1	0	0	0	0	1	0	0	0	9522	1294	45	2	49	2	MEIS3	19	47909780	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	7590797	47909780	11219203	135	46901											
KCNC3	3748	broad.mit.edu	37	chr19	50826961	50826961	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgcaggatgcggacgaagcGgaccacccgcaggaagccca	11	1	15	14	5	0	0	0	0	0	0	0	5	0	4	3	4	3	2	3	4	2	0			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:50826961G>A	uc002pru.1	-	2	1544	c.1249C>T	c.(1249-1251)CGC>TGC	p.R417C	KCNC3_uc002prt.1_Missense_Mutation_p.R53C	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	417	Helical; Voltage-sensor; Name=Segment S4; (Potential).				cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		CGGACGAAGCGGACCACCCGC	0.657													10	31					0	0	0	0	A	50826961	A	A	50826961	3	1	257	1	0	0	0	0	1	0	0	0	8055	1116	39	1	1036	1	KCNC3	19	50826961	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	2917181	50826961	8302022	136	46902											
MBOAT7	79143	broad.mit.edu	37	chr19	54677887	54677887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtagatggaggcccagtaccGaagggtgtcggccaaggaga	11	5	17	8	2	0	2	0	0	0	2	1	5	0	3	3	5	1	2	3	5	4	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:54677887G>A	uc002qdq.2	-	9	1536	c.1270C>T	c.(1270-1272)CGG>TGG	p.R424W	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Missense_Mutation_p.R108W|MBOAT7_uc010yem.1_Missense_Mutation_p.R406W|MBOAT7_uc002qdr.2_Missense_Mutation_p.R424W|MBOAT7_uc002qds.2_Missense_Mutation_p.R351W|MBOAT7_uc010yen.1_Missense_Mutation_p.R351W	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	424					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCCAGTACCGAAGGGTGTCG	0.647													16	88					0	0	0	0	A	54677887	A	A	54677887	3	1	257	1	0	0	0	0	1	0	0	0	9411	1057	37	1	152	1	MBOAT7	19	54677887	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	3850926	54677887	4451096	137	46903											
PEG3	5178	broad.mit.edu	37	chr19	57325822	57325822	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atccttgcattcatagaatgGtatagctcctttgaggggct	9	14	10	8	0	1	2	1	1	0	1	3	2	3	2	2	3	2	4	2	3	4	6			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr19:57325822G>T	uc002qnu.2	-	7	4339	c.3988C>A	c.(3988-3990)CCA>ACA	p.P1330T	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.P1301T|PEG3_uc002qnv.2_Missense_Mutation_p.P1330T|PEG3_uc002qnw.2_Missense_Mutation_p.P1206T|PEG3_uc002qnx.2_Missense_Mutation_p.P1204T|PEG3_uc010etr.2_Missense_Mutation_p.P1330T	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1330					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCATAGAATGGTATAGCTCCT	0.413													16	46					7.05477e-17	8.73881e-17	1	0	T	57325822	T	T	57325822	3	4	257	1	0	0	0	0	1	0	0	0	11774	1261	44	4	782	4	PEG3	19	57325822	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	2647935	57325822	1803161	138	46904											
CHGB	1114	broad.mit.edu	37	chr20	5904039	5904039	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttgagccgggaaagggaCgccatcacagaggcagggga	11	3	17	10	2	1	2	1	1	0	1	1	5	1	5	3	5	1	1	3	5	1	1			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr20:5904039C>T	uc002wmg.2	+	4	1555	c.1249C>T	c.(1249-1251)CGC>TGC	p.R417C	CHGB_uc010zqz.1_Missense_Mutation_p.R100C	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	417						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GGGAAAGGGACGCCATCACAG	0.532													6	67					0	0	0	0	T	5904039	T	T	5904039	3	4	257	1	0	0	0	0	1	0	0	0	3354	536	19	1	1263	1	CHGB	20	5904039	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08		5904039	57121481	139	46905											
PCSK2	5126	broad.mit.edu	37	chr20	17462541	17462541	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcggcagcgccccgcagaaGggggtgctgaaggagtggac	8	4	19	10	3	0	2	0	1	0	1	1	4	0	4	2	5	2	3	2	5	2	0			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr20:17462541G>C	uc002wpm.2	+	12	2063	c.1743G>C	c.(1741-1743)AAG>AAC	p.K581N	PCSK2_uc002wpl.2_Missense_Mutation_p.K562N|PCSK2_uc010zrm.1_Missense_Mutation_p.K546N|PCSK2_uc002wpn.2_Missense_Mutation_p.K235N	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	581					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCCCGCAGAAGGGGGTGCTGA	0.617													6	32					0	0	0	0	C	17462541	C	C	17462541	3	2	257	1	0	0	0	0	1	0	0	0	11655	991	35	4	1789	4	PCSK2	20	17462541	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	11558502	17462541	45562979	140	46906											
LBP	3929	broad.mit.edu	37	chr20	36975003	36975003	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggctctgggtgccaacccCggcttggtcgccaggatcac	6	7	14	14	2	2	0	1	0	1	0	3	2	2	1	4	5	2	2	4	5	1	1	rs149360570		TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr20:36975003C>T	uc002xic.1	+	1	119	c.84C>T	c.(82-84)CCC>CCT	p.P28P		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	28					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				GTGCCAACCCCGGCTTGGTCG	0.612													7	47					0	0	0	0	T	36975003	T	T	36975003	2	4	257	1	0	0	0	0	0	0	0	1	8691	639	23	1		1	LBP	20	36975003	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	19512462	36975003	26050517	141	46907											
TSHZ2	128553	broad.mit.edu	37	chr20	51870578	51870578	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaacccagcctgttcagctCggtgcagttgtaccgacaga	10	8	11	12	2	1	1	1	0	0	1	2	3	1	1	3	1	5	5	3	1	2	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr20:51870578C>T	uc002xwo.2	+	2	1537	c.581C>T	c.(580-582)TCG>TTG	p.S194L		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	194					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CTGTTCAGCTCGGTGCAGTTG	0.562													8	40					0	0	0	0	T	51870578	T	T	51870578	3	4	257	1	0	0	0	0	1	0	0	0	16691	893	31	1	587	1	TSHZ2	20	51870578	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	14895575	51870578	11154942	142	46908											
KRTAP6-1	337966	broad.mit.edu	37	chr21	31986075	31986075	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agagggagcgggagccatagCcatagccacagcccagtctg	11	4	14	12	1	1	1	0	0	1	1	1	3	1	3	4	2	5	0	4	2	2	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr21:31986075C>A	uc002yop.2	-	1	149	c.149G>T	c.(148-150)GGC>GTC	p.G50V	KRTAP20-1_uc011ade.1_5'Flank	NM_181602	NP_853633	Q3LI64	KRA61_HUMAN	keratin associated protein 6-1	50						cytosol|intermediate filament					0						GGAGCCATAGCCATAGCCACA	0.592													19	111					5.03518e-11	6.04222e-11	1	0	A	31986075	A	A	31986075	3	1	257	1	0	0	0	0	1	0	0	0	8609	739	26	4	70	4	KRTAP6-1	21	31986075	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08		31986075	16143820	143	46909											
CCT8L2	150160	broad.mit.edu	37	chr22	17071848	17071848	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagagtcaggattccagatCtcctgatgtgtgggactttt	8	15	11	7	0	2	3	1	1	1	2	4	5	3	5	2	2	0	0	2	2	1	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr22:17071848C>A	uc002zlp.1	-	1	1853	c.1593G>T	c.(1591-1593)GAG>GAT	p.E531D		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	531					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GATTCCAGATCTCCTGATGTG	0.438													31	108					4.4194e-11	5.33664e-11	1	0	A	17071848	A	A	17071848	3	1	257	1	0	0	0	0	1	0	0	0	2976	912	32	2	84	2	CCT8L2	22	17071848	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08		17071848	34232718	144	46910											
TRIOBP	11078	broad.mit.edu	37	chr22	38165092	38165092	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctatcggagcagtactcgcaGaagtgcctggagattggggc	9	8	15	9	2	0	2	0	0	0	2	2	4	0	3	1	4	3	3	1	4	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chr22:38165092G>A	uc003atr.2	+	20	6904	c.6633G>A	c.(6631-6633)CAG>CAA	p.Q2211Q	TRIOBP_uc003atu.2_Silent_p.Q2039Q|TRIOBP_uc003atw.2_Silent_p.Q498Q|TRIOBP_uc003atx.1_Silent_p.Q94Q|TRIOBP_uc010gxh.2_Silent_p.Q94Q	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	2211	Potential.				actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					AGTACTCGCAGAAGTGCCTGG	0.637													16	52					0	0	0	0	A	38165092	A	A	38165092	2	1	257	1	0	0	0	0	0	0	0	1	16620	933	33	2		2	TRIOBP	22	38165092	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	21093244	38165092	13139474	145	46911											
FANCB	2187	broad.mit.edu	37	chrX	14871234	14871235	+	Frame_Shift_Ins	INS	-	T	T																															tttgtaagattttgaaataaINSttttttccttaagcaacaga																										TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:14871234_14871235insT	uc004cwg.1	-	6	1520_1521	c.1252_1253insA	c.(1252-1254)ATTfs	p.I418fs	FANCB_uc004cwh.1_Frame_Shift_Ins_p.I418fs	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	418					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					TTTTGAAATAATTTTTTCCTTA	0.312								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---								T	14871235	T	T	14871234	7	5	257	1	0	1	1	0	0	0	0	0	5695	101	4	0	1346	0	FANCB	23	14871234	Frame_Shift_Ins	INS	-	TCGA-CV-7422-01A-21D-2078-08		14871234	140399326	146	46912											
REPS2	9185	broad.mit.edu	37	chrX	17072947	17072947	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttagggagcttagtgatgctGactgtgatggagccctgacc	8	11	14	8	0	0	4	0	4	0	0	0	6	0	6	2	2	3	2	2	2	2	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:17072947G>C	uc004cxv.1	+	8	1159	c.988G>C	c.(988-990)GAC>CAC	p.D330H	REPS2_uc004cxw.1_Missense_Mutation_p.D329H|REPS2_uc011miw.1_Missense_Mutation_p.D189H	NM_004726	NP_004717	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	330	EH 2.|EF-hand.|Potential.				epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					TAGTGATGCTGACTGTGATGG	0.512													8	83					0	0	0	0	C	17072947	C	C	17072947	3	2	257	1	0	0	0	0	1	0	0	0	13294	1290	45	2	1018	2	REPS2	23	17072947	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	2201713	17072947	138197613	147	46913											
GPR64	10149	broad.mit.edu	37	chrX	19039220	19039220	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcagcaataatagacaacttAcccattggtcgaatctttac	14	11	6	10	1	1	1	0	0	1	1	2	2	1	1	1	1	4	2	1	1	7	6			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:19039220A>G	uc004cyx.2	-	14	807	c.643_splice	c.e14+1	p.E215_splice	GPR64_uc004cyy.2_Splice_Site_p.E212_splice|GPR64_uc004cyz.2_Splice_Site_p.E201_splice|GPR64_uc004czb.2_Splice_Site_p.E215_splice|GPR64_uc004czc.2_Splice_Site_p.E199_splice|GPR64_uc004czd.2_Splice_Site_p.E191_splice|GPR64_uc004cze.2_Splice_Site_p.E185_splice|GPR64_uc004czf.2_Splice_Site_p.E177_splice|GPR64_uc004cza.2_Splice_Site_p.E193_splice|GPR64_uc004cyw.2_Splice_Site_p.E199_splice|GPR64_uc010nfj.2_Splice_Site_p.E185_splice	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1						neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					TAGACAACTTACCCATTGGTC	0.284													4	68					0	0	0	0	G	19039220	G	G	19039220	5	3	257	1	0	0	0	0	0	0	1	0	6743	405	14	5	2472	5	GPR64	23	19039220	Splice_Site	SNP	A	TCGA-CV-7422-01A-21D-2078-08	1966273	19039220	136231340	148	46914											
DCAF8L1	139425	broad.mit.edu	37	chrX	27998267	27998267	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccatcgtggctgtacacaacGcaggtgatgtttgttgggaa	9	11	13	8	2	0	1	0	1	0	0	1	2	0	2	1	3	2	5	1	3	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:27998267G>C	uc004dbx.1	-	1	1300	c.1185C>G	c.(1183-1185)TGC>TGG	p.C395W		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	395	WD 5.									ovary(3)|skin(1)	4						TGTACACAACGCAGGTGATGT	0.418													24	81					0	0	0	0	C	27998267	C	C	27998267	3	2	257	1	0	0	0	0	1	0	0	0	4294	1079	38	3	621	3	DCAF8L1	23	27998267	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	8959047	27998267	127272293	149	46915											
WDR13	64743	broad.mit.edu	37	chrX	48457988	48457988	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccaggccccctggcagcGtggtgcccacgtcagcagca	6	4	14	17	2	1	0	1	0	0	0	1	0	1	0	4	4	4	3	4	4	0	0			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:48457988G>A	uc004dkh.1	+	5	553	c.406G>A	c.(406-408)GTG>ATG	p.V136M	WDR13_uc010nif.1_Missense_Mutation_p.V14M|WDR13_uc004dki.1_Missense_Mutation_p.V44M|WDR13_uc004dkj.1_Missense_Mutation_p.V136M|WDR13_uc004dkk.1_Missense_Mutation_p.V44M|WDR13_uc004dkl.3_Missense_Mutation_p.V44M|WDR13_uc011mme.1_Missense_Mutation_p.V14M	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	136						cytoplasm|nucleus				ovary(2)	2						CCCTGGCAGCGTGGTGCCCAC	0.617													15	98					0	0	0	0	A	48457988	A	A	48457988	3	1	257	1	0	0	0	0	1	0	0	0	17343	1145	40	1	420	1	WDR13	23	48457988	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	20459721	48457988	106812572	150	46916											
GSPT2	23708	broad.mit.edu	37	chrX	51486870	51486870	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcagctcggctttcagcCgtaagctcaacgtcaacgcc	8	8	8	17	4	4	0	4	0	0	0	5	0	4	0	3	1	5	4	3	1	3	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:51486870C>T	uc004dpl.2	+	1	374	c.148C>T	c.(148-150)CGT>TGT	p.R50C		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	50					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					GGCTTTCAGCCGTAAGCTCAA	0.697													10	38					0	0	0	0	T	51486870	T	T	51486870	3	4	257	1	0	0	0	0	1	0	0	0	6866	652	23	1	150	1	GSPT2	23	51486870	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	3028882	51486870	103783690	151	46917											
FGD1	2245	broad.mit.edu	37	chrX	54492144	54492144	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttacctgcacctcatggatGatgactttaaactgggtgga	10	12	10	9	0	1	2	1	2	0	0	1	4	1	4	2	3	3	1	2	3	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:54492144G>T	uc004dtg.2	-	7	2216	c.1482C>A	c.(1480-1482)ATC>ATA	p.I494I	FGD1_uc011moi.1_Silent_p.I252I	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	494	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CCTCATGGATGATGACTTTAA	0.562													6	71					5.9392e-07	6.86944e-07	1	0	T	54492144	T	T	54492144	2	4	257	1	0	0	0	0	0	0	0	1	5864	1280	45	2		2	FGD1	23	54492144	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	3005274	54492144	100778416	152	46918											
MED12	9968	broad.mit.edu	37	chrX	70347860	70347860	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaccctgcagctcacacCttcacctacacggggctagg	10	6	10	15	1	2	1	2	0	0	1	2	2	2	1	3	3	4	3	3	3	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:70347860C>G	uc004dyy.2	+	22	3298	c.3099C>G	c.(3097-3099)ACC>ACG	p.T1033T	MED12_uc011mpq.1_Silent_p.T1033T|MED12_uc004dyz.2_Silent_p.T1033T|MED12_uc004dza.2_Silent_p.T880T|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1033					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CAGCTCACACCTTCACCTACA	0.527													7	68					0	0	0	0	G	70347860	G	G	70347860	2	3	257	1	0	0	0	0	0	0	0	1	9481	668	24	4		4	MED12	23	70347860	Silent	SNP	C	TCGA-CV-7422-01A-21D-2078-08	15855716	70347860	84922700	153	46919											
PCDH11X	27328	broad.mit.edu	37	chrX	91090649	91090649	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgttgaaagaccttaactTgtcgctgattccaaacaagt	12	13	7	9	1	0	3	0	2	0	1	2	3	1	3	2	0	2	2	2	0	4	5			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:91090649T>C	uc004efk.1	+	1	991	c.146T>C	c.(145-147)TTG>TCG	p.L49S	PCDH11X_uc004efl.1_Missense_Mutation_p.L49S|PCDH11X_uc004efo.1_Missense_Mutation_p.L49S|PCDH11X_uc010nmv.1_Missense_Mutation_p.L49S|PCDH11X_uc004efm.1_Missense_Mutation_p.L49S|PCDH11X_uc004efn.1_Missense_Mutation_p.L49S|PCDH11X_uc004efh.1_Missense_Mutation_p.L49S|PCDH11X_uc004efj.1_Missense_Mutation_p.L49S	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	49	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GACCTTAACTTGTCGCTGATT	0.473													11	88					0	0	0	0	C	91090649	C	C	91090649	3	2	257	1	0	0	0	0	1	0	0	0	11562	1821	63	5	148	5	PCDH11X	23	91090649	Missense_Mutation	SNP	T	TCGA-CV-7422-01A-21D-2078-08	20742789	91090649	64179911	154	46920											
PCDH11X	27328	broad.mit.edu	37	chrX	91090730	91090730	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggagatgtgccactgattcGaattgaagaggatactggtg	11	10	14	6	2	0	4	0	2	0	2	1	7	0	5	1	3	2	0	1	3	3	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:91090730G>A	uc004efk.1	+	1	1072	c.227G>A	c.(226-228)CGA>CAA	p.R76Q	PCDH11X_uc004efl.1_Missense_Mutation_p.R76Q|PCDH11X_uc004efo.1_Missense_Mutation_p.R76Q|PCDH11X_uc010nmv.1_Missense_Mutation_p.R76Q|PCDH11X_uc004efm.1_Missense_Mutation_p.R76Q|PCDH11X_uc004efn.1_Missense_Mutation_p.R76Q|PCDH11X_uc004efh.1_Missense_Mutation_p.R76Q|PCDH11X_uc004efj.1_Missense_Mutation_p.R76Q	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	76	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CCACTGATTCGAATTGAAGAG	0.438													21	141					0	0	0	0	A	91090730	A	A	91090730	3	1	257	1	0	0	0	0	1	0	0	0	11562	1058	37	1	229	1	PCDH11X	23	91090730	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	81	91090730	64179830	155	46921											
CENPI	2491	broad.mit.edu	37	chrX	100403043	100403043	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctttgggaaaggaatatatAttgaccctgaaatcctagaa	15	11	8	7	0	0	3	0	2	0	1	1	5	1	5	3	2	0	0	3	2	8	6			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:100403043A>T	uc004egx.2	+	19	2257	c.1987A>T	c.(1987-1989)ATT>TTT	p.I663F	CENPI_uc011mrg.1_Missense_Mutation_p.I663F	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	663					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						AGGAATATATATTGACCCTGA	0.363													16	178					0	0	0	0	T	100403043	T	T	100403043	3	4	257	1	0	0	0	0	1	0	0	0	3248	449	16	5	2057	5	CENPI	23	100403043	Missense_Mutation	SNP	A	TCGA-CV-7422-01A-21D-2078-08	9312313	100403043	54867517	156	46922											
DOCK11	139818	broad.mit.edu	37	chrX	117815169	117815169	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctctactgacgtggacatGattcagctccaacttaaatt	11	13	6	11	1	2	2	1	2	1	0	4	3	4	3	2	1	3	1	2	1	4	4			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:117815169G>C	uc004eqp.2	+	50	5883	c.5820G>C	c.(5818-5820)ATG>ATC	p.M1940I	DOCK11_uc004eqq.2_Missense_Mutation_p.M1719I	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1940	DHR-2.				blood coagulation	cytosol	GTP binding			ovary(3)	3						ACGTGGACATGATTCAGCTCC	0.373													29	86					0	0	0	0	C	117815169	C	C	117815169	3	2	257	1	0	0	0	0	1	0	0	0	4708	1290	45	2	6018	2	DOCK11	23	117815169	Missense_Mutation	SNP	G	TCGA-CV-7422-01A-21D-2078-08	17412126	117815169	37455391	157	46923											
CUL4B	8450	broad.mit.edu	37	chrX	119672528	119672528	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacctaccatgtttaagtttGgacagcattgatttttcagc	11	15	7	8	0	1	1	1	1	0	0	1	2	1	2	2	1	4	3	2	1	3	7			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:119672528G>T	uc004esw.2	-	15	2330	c.1893C>A	c.(1891-1893)TCC>TCA	p.S631S	CUL4B_uc010nqq.2_Silent_p.S330S|CUL4B_uc004esv.2_Silent_p.S613S	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	631					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						GTTTAAGTTTGGACAGCATTG	0.383													25	103					7.26314e-15	8.88231e-15	1	0	T	119672528	T	T	119672528	2	4	257	1	0	0	0	0	0	0	0	1	4075	1335	47	4		4	CUL4B	23	119672528	Silent	SNP	G	TCGA-CV-7422-01A-21D-2078-08	1857359	119672528	35598032	158	46924											
THOC2	57187	broad.mit.edu	37	chrX	122837338	122837338	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcagcaagaatggagggCatatcctcacgaaattccta	15	8	8	10	1	2	1	2	0	0	1	4	3	4	2	2	2	1	2	2	2	5	3			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:122837338C>T	uc004etu.2	-	4	272	c.240G>A	c.(238-240)ATG>ATA	p.M80I	THOC2_uc011muh.1_Missense_Mutation_p.M1I|THOC2_uc011mui.1_5'UTR	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	80					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						GAATGGAGGGCATATCCTCAC	0.303													5	80					0	0	0	0	T	122837338	T	T	122837338	3	4	257	1	0	0	0	0	1	0	0	0	15931	710	25	4	4681	4	THOC2	23	122837338	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	3164810	122837338	32433222	159	46925											
HMGB3	3149	broad.mit.edu	37	chrX	150156302	150156302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgatggtgcaaagggtcctgCtaaagttgcccggaaaaagg	12	8	14	7	1	0	1	0	1	0	0	1	2	1	2	2	4	3	3	2	4	5	2			TCGA-CV-7422-01A-21D-2078-08	TCGA-CV-7422-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	5eb3f291-082c-48a8-b653-09264342adee	f3de3c44-abb1-4a38-945c-cbdd7dd132a5	g.chrX:150156302C>T	uc004fep.2	+	5	610	c.518C>T	c.(517-519)GCT>GTT	p.A173V	HMGB3_uc004feq.2_3'UTR|HMGB3_uc004fer.2_Missense_Mutation_p.A173V	NM_005342	NP_005333	O15347	HMGB3_HUMAN	high-mobility group box 3	173					DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGGTCCTGCTAAAGTTGCC	0.279													5	84					0	0	0	0	T	150156302	T	T	150156302	3	4	257	1	0	0	0	0	1	0	0	0	7266	797	28	4	532	4	HMGB3	23	150156302	Missense_Mutation	SNP	C	TCGA-CV-7422-01A-21D-2078-08	27318964	150156302	5114258	160	46926											
PADI6	353238	broad.mit.edu	37	chr1	17727771	17727771	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccccaaatcaaggggacctGctgcctggaagaaaagattt	13	7	11	10	0	1	2	1	0	0	2	1	4	1	4	4	3	2	1	4	3	5	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:17727771G>A	uc001bak.1	+	17	1922	c.1922G>A	c.(1921-1923)TGC>TAC	p.C641Y		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	633					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AAGGGGACCTGCTGCCTGGAA	0.537													4	38					0	0	0	0	A	17727771	A	A	17727771	3	1	258	1	0	0	0	0	1	0	0	0	11435	1319	46	4	1985	4	PADI6	1	17727771	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08		17727771	231522850	1	46927											
HCRTR1	3061	broad.mit.edu	37	chr1	32084929	32084931	+	In_Frame_Del	DEL	GAG	-	-																															atctgtacccaaaacagtatGagtgggtcctcatcgcagcc																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:32084929_32084931delGAG	uc009vtx.2	+	3	521_523	c.136_138delGAG	c.(136-138)GAGdel	p.E46del	HCRTR1_uc001btb.2_Intron|HCRTR1_uc001btc.3_In_Frame_Del_p.19_20MS>I|HCRTR1_uc001btd.2_In_Frame_Del_p.E46del|HCRTR1_uc010ogl.1_In_Frame_Del_p.E46del	NM_001525	NP_001516	O43613	OX1R_HUMAN	orexin receptor 1	46	Extracellular (Potential).				feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				ovary(1)	1		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		AAAACAGTATGAGTGGGTCCTCA	0.606													---	---	---								-	32084931	-	-	32084929	7	5	258	1	0	1	0	1	0	0	0	0	7040	1291	45	0	138	0	HCRTR1	1	32084929	In_Frame_Del	DEL	GAG	TCGA-CV-7423-01A-11D-2078-08	14357158	32084929	217165692	2	46928											
KIAA0754	643314	broad.mit.edu	37	chr1	39878082	39878082	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtctgtggagaaagtttgTgatgaggatggtgaggcaaa	11	12	16	2	0	1	4	0	3	1	1	1	6	1	5	0	4	0	2	0	4	2	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:39878082T>C	uc009vvt.1	+	1	2907	c.2145T>C	c.(2143-2145)TGT>TGC	p.C715C	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	579											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAAAGTTTGTGATGAGGATG	0.423													6	38					0	0	0	0	C	39878082	C	C	39878082	2	2	258	1	0	0	0	0	0	0	0	1	8231	1702	59	5		5	KIAA0754	1	39878082	Silent	SNP	T	TCGA-CV-7423-01A-11D-2078-08	7793153	39878082	209372539	3	46929											
EVI5	7813	broad.mit.edu	37	chr1	93167729	93167729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatccaactataaaagcaCttccttgacagtaaccaacc	17	8	3	13	0	0	1	0	1	0	0	2	1	2	1	4	0	4	2	4	0	7	5			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:93167729C>T	uc001dox.2	-	5	750	c.740G>A	c.(739-741)AGT>AAT	p.S247N	EVI5_uc010otf.1_Missense_Mutation_p.S247N	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	247	Dimerization.|Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Rab-GAP TBC.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		TATAAAAGCACTTCCTTGACA	0.308													8	34					0	0	0	0	T	93167729	T	T	93167729	3	4	258	1	0	0	0	0	1	0	0	0	5313	565	20	4	1748	4	EVI5	1	93167729	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	53289647	93167729	156082892	4	46930											
ABCA4	24	broad.mit.edu	37	chr1	94496611	94496611	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtcaaagcggggtattcGccaaaaggagggataacaat	15	6	14	6	2	1	0	1	0	0	0	2	2	1	2	1	5	2	1	1	5	6	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:94496611G>A	uc001dqh.2	-	28	4298	c.4194C>T	c.(4192-4194)GGC>GGT	p.G1398G		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1398	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CGGGGTATTCGCCAAAAGGAG	0.512													6	23					0	0	0	0	A	94496611	A	A	94496611	2	1	258	1	0	0	0	0	0	0	0	1	34	1074	38	1		1	ABCA4	1	94496611	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08	1328882	94496611	154754010	5	46931											
CSF1	1435	broad.mit.edu	37	chr1	110456910	110456910	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggctccctgctgttgttggtCtgtctcctggcgagcaggag	3	12	15	11	1	2	0	0	0	2	0	4	2	3	1	2	4	2	5	2	4	0	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:110456910C>T	uc001dyu.2	+	2	482	c.69C>T	c.(67-69)GTC>GTT	p.V23V	CSF1_uc001dyt.2_Silent_p.V23V|CSF1_uc001dyv.3_Silent_p.V23V|CSF1_uc001dyw.3_Silent_p.V23V	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	23					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGTTGTTGGTCTGTCTCCTGG	0.587													16	29					0	0	0	0	T	110456910	T	T	110456910	2	4	258	1	0	0	0	0	0	0	0	1	3948	900	32	2		2	CSF1	1	110456910	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	15960299	110456910	138793711	6	46932											
RSBN1	54665	broad.mit.edu	37	chr1	114354936	114354936	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccgaccgcccccccgtcCgcgcatcgcgcaagcgccgc	4	2	12	23	9	0	0	0	0	0	0	2	1	1	0	7	1	1	2	7	1	1	0			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:114354936C>T	uc001edq.2	-	1	135	c.99G>A	c.(97-99)GCG>GCA	p.A33A	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	33						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCCCCCGTCCGCGCATCGCG	0.672													4	53					0	0	0	0	T	114354936	T	T	114354936	2	4	258	1	0	0	0	0	0	0	0	1	13761	639	23	1		1	RSBN1	1	114354936	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	3898026	114354936	134895685	7	46933											
ANXA9	8416	broad.mit.edu	37	chr1	150967079	150967079	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcccaattaccaagtcctGattcgcatccttatctctcg	9	12	6	14	2	1	1	0	1	1	0	6	2	3	1	4	0	2	1	4	0	4	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:150967079G>A	uc001ewa.2	+	13	1349	c.879G>A	c.(877-879)CTG>CTA	p.L293L		NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9	293	Annexin 4.				cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACCAAGTCCTGATTCGCATCC	0.483													12	149					0	0	0	0	A	150967079	A	A	150967079	2	1	258	1	0	0	0	0	0	0	0	1	725	1277	45	2		2	ANXA9	1	150967079	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08	36612143	150967079	98283542	8	46934											
FAM5C	339479	broad.mit.edu	37	chr1	190203579	190203579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggttgtcatagttactgcagCcaagaggaccagtccgtgtt	9	11	12	9	1	1	1	1	0	0	1	2	2	2	2	3	2	3	4	3	2	3	4			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:190203579C>T	uc001gse.1	-	5	879	c.647G>A	c.(646-648)GGC>GAC	p.G216D	FAM5C_uc010pot.1_Missense_Mutation_p.G114D	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	216						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GTTACTGCAGCCAAGAGGACC	0.378													9	51					0	0	0	0	T	190203579	T	T	190203579	3	4	258	1	0	0	0	0	1	0	0	0	5626	739	26	4	1669	4	FAM5C	1	190203579	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	39236500	190203579	59047042	9	46935											
KIF21B	23046	broad.mit.edu	37	chr1	200946364	200946364	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	taagctcccagatgcggacgGcattgcccgaggcggcgtac	8	6	14	13	5	0	1	0	0	0	1	1	3	1	2	2	4	4	3	2	4	2	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:200946364G>A	uc001gvs.1	-	31	4618	c.4301C>T	c.(4300-4302)GCC>GTC	p.A1434V	KIF21B_uc001gvr.1_Missense_Mutation_p.A1421V|KIF21B_uc009wzl.1_Missense_Mutation_p.A1434V|KIF21B_uc010ppn.1_Missense_Mutation_p.A1421V	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1434	WD 3.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GATGCGGACGGCATTGCCCGA	0.632													4	98					0	0	0	0	A	200946364	A	A	200946364	3	1	258	1	0	0	0	0	1	0	0	0	8328	1203	42	4	632	4	KIF21B	1	200946364	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	10742785	200946364	48304257	10	46936											
CR1	1378	broad.mit.edu	37	chr1	207793408	207793408	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctctggccaaatgtacctCtcgtaagtgcaagtgcaagg	10	10	10	11	1	2	0	0	0	2	0	4	0	3	0	3	2	3	4	3	2	5	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:207793408C>G	uc001hfy.2	+	35	6040	c.5900C>G	c.(5899-5901)TCT>TGT	p.S1967C	CR1_uc001hfx.2_Missense_Mutation_p.S2417C	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1967	Sushi 30.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						AAATGTACCTCTCGTAAGTGC	0.493											OREG0014194	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	14					0	0	0	0	G	207793408	G	G	207793408	3	3	258	1	0	0	0	0	1	0	0	0	3855	913	32	2	7420	2	CR1	1	207793408	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	6847044	207793408	41457213	11	46937											
CABC1	56997	broad.mit.edu	37	chr1	227169739	227169739	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcccacagggaagaaggccGtgctgggttccagtcctttc	7	8	13	13	2	0	1	0	0	0	1	3	2	2	2	4	3	1	2	4	3	2	2	rs148376283		TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:227169739G>A	uc001hqm.1	+	11	4161	c.742G>A	c.(742-744)GTG>ATG	p.V248M	CABC1_uc001hqn.1_Missense_Mutation_p.V248M|CABC1_uc009xeq.1_Missense_Mutation_p.V196M|CABC1_uc010pvq.1_Translation_Start_Site|CABC1_uc010pvr.1_Translation_Start_Site|CABC1_uc001hqo.1_Translation_Start_Site|CABC1_uc009xer.1_5'Flank	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	248					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				GAAGAAGGCCGTGCTGGGTTC	0.652													29	36					0	0	0	0	A	227169739	A	A	227169739	3	1	258	1	0	0	0	0	1	0	0	0	2539	1145	40	1	760	1	CABC1	1	227169739	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	19376331	227169739	22080882	12	46938											
NID1	4811	broad.mit.edu	37	chr1	236180536	236180536	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttattgcagattgtgtggctCccacacactgagggttgttc	7	14	11	9	0	0	2	0	1	0	1	2	2	1	2	1	2	1	4	1	2	1	5			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:236180536C>T	uc001hxo.2	-	10	2268	c.2166G>A	c.(2164-2166)GGG>GGA	p.G722G	NID1_uc009xgd.2_Intron	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	722	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TTGTGTGGCTCCCACACACTG	0.433													18	93					0	0	0	0	T	236180536	T	T	236180536	2	4	258	1	0	0	0	0	0	0	0	1	10468	842	30	2		2	NID1	1	236180536	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	9010797	236180536	13070085	13	46939											
CHRM3	1131	broad.mit.edu	37	chr1	240071198	240071198	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctctggcttgccattgactaCgtagccagcaatgcctctgt	7	12	9	13	1	2	1	0	1	2	0	2	1	2	1	3	1	5	3	3	1	3	4			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:240071198C>A	uc001hyp.2	+	5	1226	c.447C>A	c.(445-447)TAC>TAA	p.Y149*		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	149	Helical; Name=3; (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CCATTGACTACGTAGCCAGCA	0.473													27	34					9.86323e-18	1.12723e-17	1	0	A	240071198	A	A	240071198	4	1	258	1	0	0	0	0	0	1	0	0	3393	547	19	3	449	3	CHRM3	1	240071198	Nonsense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	3890662	240071198	9179423	14	46940											
FMN2	56776	broad.mit.edu	37	chr1	240492666	240492666	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgaactgtcactaatcccCaacttttcagagcgagtctt	11	13	6	11	1	3	2	2	1	1	1	4	3	4	2	2	0	3	0	2	0	4	5			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:240492666C>A	uc010pyd.1	+	10	4560	c.4335C>A	c.(4333-4335)CCC>CCA	p.P1445P	FMN2_uc010pye.1_Silent_p.P1449P|FMN2_uc010pyf.1_Silent_p.P91P|FMN2_uc010pyg.1_Silent_p.P41P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1445	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CACTAATCCCCAACTTTTCAG	0.363													11	87					0.000673444	0.000715162	1	0	A	240492666	A	A	240492666	2	1	258	1	0	0	0	0	0	0	0	1	5982	581	21	4		4	FMN2	1	240492666	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	421468	240492666	8757955	15	46941											
TTC27	55622	broad.mit.edu	37	chr2	33012122	33012122	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctggcagatttgggaaaactAcatcctcaccagcactgacg	12	8	9	12	1	1	2	1	1	0	1	2	3	2	3	2	2	3	2	2	2	3	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:33012122A>G	uc002rom.2	+	16	2135	c.1904A>G	c.(1903-1905)TAC>TGC	p.Y635C	TTC27_uc010ymx.1_Missense_Mutation_p.Y585C|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	635	TPR 6.|HAT 2.						protein binding			central_nervous_system(1)	1						TGGGAAAACTACATCCTCACC	0.393													11	50					0	0	0	0	G	33012122	G	G	33012122	3	3	258	1	0	0	0	0	1	0	0	0	16763	391	14	5	1966	5	TTC27	2	33012122	Missense_Mutation	SNP	A	TCGA-CV-7423-01A-11D-2078-08		33012122	210187251	16	46942											
TTC7A	57217	broad.mit.edu	37	chr2	47238537	47238537	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggaccccaccgtgccccTgatggccgcgaaggtctgca	6	6	12	17	4	1	1	0	1	1	0	2	3	1	2	6	3	2	1	6	3	1	0			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-11A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	0d495571-2b44-458d-9c80-58a9e13d1ccc	g.chr2:47238537T>C	uc002rvo.2	+	11	1723	c.1355T>C	c.(1354-1356)CTG>CCG	p.L452P	TTC7A_uc002rvm.2_Missense_Mutation_p.L418P|TTC7A_uc002rvn.1_Missense_Mutation_p.L333P|TTC7A_uc010fbb.2_Missense_Mutation_p.L452P|TTC7A_uc010fbc.2_Missense_Mutation_p.L98P|TTC7A_uc002rvp.2_Missense_Mutation_p.L333P|TTC7A_uc002rvq.2_Missense_Mutation_p.L192P|TTC7A_uc002rvr.2_5'UTR	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	452							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			ACCGTGCCCCTGATGGCCGCG	0.637													3	14					0	0	0	0	C	47238537	C	C	47238537	3	2	258	1	0	0	0	0	1	0	0	0	16780	1580	55	5	1397	5	TTC7A	2	47238537	Missense_Mutation	SNP	T	TCGA-CV-7423-01A-11D-2078-08	14226415	47238537	195960836	17	46943											
NRXN1	9378	broad.mit.edu	37	chr2	50280443	50280443	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttgtcgggggctttcctCttctggctgtgctagtagcc	2	16	12	11	1	2	0	0	0	2	0	4	0	3	0	2	3	2	4	2	3	2	6			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:50280443C>T	uc010fbp.2	-	4	1706	c.899G>A	c.(898-900)AGA>AAA	p.R300K	NRXN1_uc002rxb.3_Missense_Mutation_p.R1037K|NRXN1_uc010fbq.2_Missense_Mutation_p.R1405K|NRXN1_uc002rxe.3_Missense_Mutation_p.R1335K	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	300	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGGCTTTCCTCTTCTGGCTGT	0.453													4	100					0	0	0	0	T	50280443	T	T	50280443	3	4	258	1	0	0	0	0	1	0	0	0	10719	913	32	2	441	2	NRXN1	2	50280443	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	3041906	50280443	192918930	18	46944											
CTNNA2	1496	broad.mit.edu	37	chr2	80646578	80646578	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgtttcaactgtagcttcGgaaagcagtgatggatcaca	11	13	10	7	1	2	1	2	1	0	0	3	3	2	3	0	2	3	4	0	2	3	4			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:80646578G>A	uc010ysh.1	+	8	1147	c.1142G>A	c.(1141-1143)CGG>CAG	p.R381Q	CTNNA2_uc010yse.1_Missense_Mutation_p.R381Q|CTNNA2_uc010ysf.1_Missense_Mutation_p.R381Q|CTNNA2_uc010ysg.1_Missense_Mutation_p.R381Q|CTNNA2_uc010ysi.1_Missense_Mutation_p.R13Q	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	381					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CTGTAGCTTCGGAAAGCAGTG	0.358													8	51					0	0	0	0	A	80646578	A	A	80646578	3	1	258	1	0	0	0	0	1	0	0	0	4030	1116	39	1	964	1	CTNNA2	2	80646578	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	30366135	80646578	162552795	19	46945											
PSD4	23550	broad.mit.edu	37	chr2	113942946	113942946	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcctctctcaacaggcctCtctcagccctgagggctggc	5	10	10	16	0	4	1	2	1	2	0	6	1	4	1	3	3	3	1	3	3	1	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:113942946C>T	uc002tjc.2	+	4	1361	c.1178C>T	c.(1177-1179)TCT>TTT	p.S393F	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Missense_Mutation_p.S392F|PSD4_uc002tjf.2_5'UTR	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	393					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CAACAGGCCTCTCTCAGCCCT	0.413													21	90					0	0	0	0	T	113942946	T	T	113942946	3	4	258	1	0	0	0	0	1	0	0	0	12711	913	32	2	1188	2	PSD4	2	113942946	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	33296368	113942946	129256427	20	46946											
SCN2A	6326	broad.mit.edu	37	chr2	166152455	166152455	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taagagacccaaacaggaacGcaaggatgaggatgatgaaa	19	4	12	6	1	0	4	0	3	0	1	0	8	0	7	1	3	2	1	1	3	5	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:166152455G>A	uc002udc.2	+	2	412	c.122G>A	c.(121-123)CGC>CAC	p.R41H	SCN2A_uc002udd.2_Missense_Mutation_p.R41H|SCN2A_uc002ude.2_Missense_Mutation_p.R41H	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	41					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AAACAGGAACGCAAGGATGAG	0.473													9	19					0	0	0	0	A	166152455	A	A	166152455	3	1	258	1	0	0	0	0	1	0	0	0	13981	1087	38	1	124	1	SCN2A	2	166152455	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	52209509	166152455	77046918	21	46947											
TTN	7273	broad.mit.edu	37	chr2	179451387	179451387	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccactgagtactctgtccagCgatctgcaggctgctcttct	6	12	9	14	1	4	1	0	1	4	0	5	2	5	1	2	1	4	4	2	1	1	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:179451387C>T	uc010zfg.1	-	257	56761	c.56537G>A	c.(56536-56538)CGC>CAC	p.R18846H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R12541H|TTN_uc010zfi.1_Missense_Mutation_p.R12474H|TTN_uc010zfj.1_Missense_Mutation_p.R12349H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19773							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTGTCCAGCGATCTGCAGG	0.468													26	73					0	0	0	0	T	179451387	T	T	179451387	3	4	258	1	0	0	0	0	1	0	0	0	16803	768	27	1	43958	1	TTN	2	179451387	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	13298932	179451387	63747986	22	46948											
TTN	7273	broad.mit.edu	37	chr2	179606565	179606565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagattcagacaaaagttCaagtgtttcatttattttag	13	16	8	4	0	3	2	3	0	0	2	3	3	3	2	0	1	0	2	0	1	5	7			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:179606565C>T	uc010zfh.1	-	46	11106	c.10882G>A	c.(10882-10884)GAA>AAA	p.E3628K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E3561K|TTN_uc010zfj.1_Missense_Mutation_p.E3436K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	3613							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E3436K(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACAAAAGTTCAAGTGTTTCA	0.373													4	12					0	0	0	0	T	179606565	T	T	179606565	3	4	258	1	0	0	0	0	1	0	0	0	16803	835	29	2	93394	2	TTN	2	179606565	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	155178	179606565	63592808	23	46949											
CNTN6	27255	broad.mit.edu	37	chr3	1424634	1424636	+	In_Frame_Del	DEL	AGA	-	-																															attctgcccaagtcaattccAgaagaactgcagaatgggga																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr3:1424634_1424636delAGA	uc003boz.2	+	18	2442_2444	c.2175_2177delAGA	c.(2173-2178)CCAGAA>CCA	p.E727del	CNTN6_uc011asj.1_In_Frame_Del_p.E655del|CNTN6_uc003bpa.2_In_Frame_Del_p.E727del	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	727	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AGTCAATTCCAGAAGAACTGCAG	0.384													---	---	---								-	1424636	-	-	1424634	7	5	258	1	0	1	0	1	0	0	0	0	3660	175	7	0	2241	0	CNTN6	3	1424634	In_Frame_Del	DEL	AGA	TCGA-CV-7423-01A-11D-2078-08		1424634	196597796	24	46950											
DPPA4	55211	broad.mit.edu	37	chr3	109049479	109049479	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaagttgtcaccacaactgTattaactccctcaaggagag	14	9	8	10	0	2	2	2	0	0	2	3	3	3	2	2	1	2	2	2	1	5	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr3:109049479T>G	uc003dxq.3	-	5	626	c.571A>C	c.(571-573)ACA>CCA	p.T191P	DPPA4_uc011bho.1_Intron|DPPA4_uc011bhp.1_Missense_Mutation_p.T191P	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	191						nucleus	protein binding			upper_aerodigestive_tract(1)	1						ACCACAACTGTATTAACTCCC	0.562													43	35					0	0	0	0	G	109049479	G	G	109049479	3	3	258	1	0	0	0	0	1	0	0	0	4758	1638	57	5	355	5	DPPA4	3	109049479	Missense_Mutation	SNP	T	TCGA-CV-7423-01A-11D-2078-08	107624845	109049479	88972951	25	46951											
GRAMD1C	54762	broad.mit.edu	37	chr3	113563487	113563487	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cataattggagtggtgactgGagcttttgggtaatttcttt	8	17	12	4	0	1	1	0	1	1	0	1	3	1	3	0	4	1	2	0	4	2	7			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr3:113563487G>C	uc003eaq.3	+	2	241	c.165G>C	c.(163-165)TGG>TGC	p.W55C	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	55						integral to membrane				ovary(2)|skin(1)	3						GTGGTGACTGGAGCTTTTGGG	0.318													11	68					0	0	0	0	C	113563487	C	C	113563487	3	2	258	1	0	0	0	0	1	0	0	0	6788	1183	41	2	171	2	GRAMD1C	3	113563487	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	4514008	113563487	84458943	26	46952											
SI	6476	broad.mit.edu	37	chr3	164725717	164725717	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acctgggaaataaggtggatAatttagttcgtcatttctgc	11	14	10	6	1	2	0	1	0	1	0	3	2	2	2	1	3	1	1	1	3	4	6			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr3:164725717A>G	uc003fei.2	-	36	4311	c.4249T>C	c.(4249-4251)TAT>CAT	p.Y1417H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1417	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAAGGTGGATAATTTAGTTCG	0.239										HNSCC(35;0.089)			8	75					0	0	0	0	G	164725717	G	G	164725717	3	3	258	1	0	0	0	0	1	0	0	0	14362	362	13	5	1286	5	SI	3	164725717	Missense_Mutation	SNP	A	TCGA-CV-7423-01A-11D-2078-08	51162230	164725717	33296713	27	46953											
TRA2B	6434	broad.mit.edu	37	chr3	185644425	185644425	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acctggactttgatctggaaCgcctggaatcttccttggag	8	12	11	10	1	2	1	0	1	2	0	3	5	3	5	3	4	1	0	3	4	2	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr3:185644425C>T	uc003fpv.2	-	2	410	c.134G>A	c.(133-135)CGT>CAT	p.R45H	TRA2B_uc003fpt.2_5'Flank|TRA2B_uc003fpu.2_RNA|TRA2B_uc010hym.2_Intron|TRA2B_uc003fpw.2_Missense_Mutation_p.R45H	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	45	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2						TGATCTGGAACGCCTGGAATC	0.488													28	61					0	0	0	0	T	185644425	T	T	185644425	3	4	258	1	0	0	0	0	1	0	0	0	16501	536	19	1	764	1	TRA2B	3	185644425	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	20918708	185644425	12378005	28	46954											
ATP8A1	10396	broad.mit.edu	37	chr4	42551058	42551058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccaagacattgagcaattCatatctttcttcctgcccca	10	13	4	14	0	3	2	1	1	2	1	5	2	5	2	4	0	2	1	4	0	3	5			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr4:42551058C>T	uc003gwr.2	-	19	1856	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K	ATP8A1_uc003gws.2_Missense_Mutation_p.E527K|ATP8A1_uc011byz.1_Missense_Mutation_p.E527K	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	542	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	TTGAGCAATTCATATCTTTCT	0.308													9	40					0	0	0	0	T	42551058	T	T	42551058	3	4	258	1	0	0	0	0	1	0	0	0	1194	835	29	2	1946	2	ATP8A1	4	42551058	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08		42551058	148603218	29	46955											
IRX1	79192	broad.mit.edu	37	chr5	3600115	3600115	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggccctccgccggggcgccGctgcaacaccccgccttcct	3	5	12	21	5	0	0	0	0	0	0	2	0	2	0	8	3	2	2	8	3	1	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-11A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	0d495571-2b44-458d-9c80-58a9e13d1ccc	g.chr5:3600115G>A	uc003jde.2	+	2	1105	c.1053G>A	c.(1051-1053)CCG>CCA	p.P351P		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	351						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						ccggggcgccgcTGCAACACC	0.507													5	9					0	0	0	0	A	3600115	A	A	3600115	2	1	258	1	0	0	0	0	0	0	0	1	7882	1074	38	1		1	IRX1	5	3600115	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08		3600115	177315145	30	46956											
C5orf35	133383	broad.mit.edu	37	chr5	56207180	56207180	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctactggcagttgaacatCaaggggtgaaactgcttgaa	13	9	11	8	0	1	3	1	3	0	0	1	3	1	3	1	3	4	3	1	3	5	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:56207180C>A	uc003jqx.2	+	2	656	c.283C>A	c.(283-285)CAA>AAA	p.Q95K	C5orf35_uc003jqy.2_Intron	NM_153706	NP_714917	Q8NE22	CE035_HUMAN	hypothetical protein LOC133383	95										ovary(1)	1		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.173)		OV - Ovarian serous cystadenocarcinoma(10;2.58e-39)		AGTTGAACATCAAGGGGTGAA	0.363													22	20					3.10358e-05	3.35522e-05	1	0	A	56207180	A	A	56207180	3	1	258	1	0	0	0	0	1	0	0	0	2304	827	29	2	289	2	C5orf35	5	56207180	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	52607065	56207180	124708080	31	46957											
MAP1B	4131	broad.mit.edu	37	chr5	71491407	71491407	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctaaagacgcaaagaaatCatctactcctctgtctgaag	14	9	6	12	1	4	3	1	1	3	2	5	3	5	3	2	0	1	1	2	0	6	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:71491407C>T	uc003kbw.3	+	5	2466	c.2225C>T	c.(2224-2226)TCA>TTA	p.S742L	MAP1B_uc010iyw.1_Missense_Mutation_p.S759L|MAP1B_uc010iyx.1_Missense_Mutation_p.S616L|MAP1B_uc010iyy.1_Missense_Mutation_p.S616L	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	742	Lys-rich (highly basic, contains many KKEE and KKEI/V repeats).					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GCAAAGAAATCATCTACTCCT	0.269													8	77					0	0	0	0	T	71491407	T	T	71491407	3	4	258	1	0	0	0	0	1	0	0	0	9281	838	29	2	2243	2	MAP1B	5	71491407	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	15284227	71491407	109423853	32	46958											
ERAP1	51752	broad.mit.edu	37	chr5	96121595	96121595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caaagagtcccatccatcatCctcgtaatgcacaatgtaat	14	10	5	12	1	1	1	1	0	0	1	5	1	4	1	3	0	1	3	3	0	4	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:96121595C>T	uc003kmm.2	-	13	2187	c.1840G>A	c.(1840-1842)GAT>AAT	p.D614N	ERAP1_uc003kml.2_Missense_Mutation_p.D614N|ERAP1_uc010jbm.1_Missense_Mutation_p.D426N|ERAP1_uc003kmn.2_Missense_Mutation_p.D614N	NM_001040458	NP_001035548	Q9NZ08	ERAP1_HUMAN	type 1 tumor necrosis factor receptor shedding	614	Lumenal (Potential).				angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		CATCCATCATCCTCGTAATGC	0.413													4	49					0	0	0	0	T	96121595	T	T	96121595	3	4	258	1	0	0	0	0	1	0	0	0	5227	855	30	2	1046	2	ERAP1	5	96121595	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	24630188	96121595	84793665	33	46959											
TRIM36	55521	broad.mit.edu	37	chr5	114499269	114499269	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aggggaggggagccgaagtcGaggactgctttgattggagt	9	8	19	5	2	0	1	0	1	0	0	1	7	0	5	1	6	2	1	1	6	1	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:114499269G>C	uc003kqs.2	-	2	753	c.244C>G	c.(244-246)CGA>GGA	p.R82G	TRIM36_uc011cwc.1_Missense_Mutation_p.R70G|TRIM36_uc003kqt.2_Intron	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	82	RING-type; degenerate.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		AGCCGAAGTCGAGGACTGCTT	0.453													5	49					0	0	0	0	C	114499269	C	C	114499269	3	2	258	1	0	0	0	0	1	0	0	0	16577	1066	37	3	1978	3	TRIM36	5	114499269	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	18377674	114499269	66415991	34	46960											
PCDHA7	56141	broad.mit.edu	37	chr5	140215474	140215474	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgcgggtgggcgagcgCgcgctgtcgagctacgtgtc	4	7	19	11	7	0	0	0	0	0	0	2	3	0	0	0	2	5	3	0	2	1	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:140215474C>T	uc003lhq.2	+	1	1506	c.1506C>T	c.(1504-1506)CGC>CGT	p.R502R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.R502R	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	502	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding	p.R502H(1)		ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGCGAGCGCGCGCTGTCGA	0.677													13	79					0	0	0	0	T	140215474	T	T	140215474	2	4	258	1	0	0	0	0	0	0	0	1	11583	755	27	1		1	PCDHA7	5	140215474	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	25716205	140215474	40699786	35	46961											
SLC34A1	6569	broad.mit.edu	37	chr5	176824887	176824887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccaaggcgctggggaaacGcacggccaagtaccgctggt	9	4	16	12	4	0	0	0	0	0	0	0	1	0	1	3	6	2	4	3	6	4	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:176824887G>A	uc003mgk.3	+	13	1621	c.1520G>A	c.(1519-1521)CGC>CAC	p.R507H		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	507	Cytoplasmic (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGGGAAACGCACGGCCAAG	0.607													16	63					0	0	0	0	A	176824887	A	A	176824887	3	1	258	1	0	0	0	0	1	0	0	0	14631	1087	38	1	1657	1	SLC34A1	5	176824887	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	36609413	176824887	4090373	36	46962											
CSNK2B	1460	broad.mit.edu	37	chr6	31635648	31635648	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cttccatgtcctgacaggtgGatgaagactacatccaggac	11	9	10	11	0	0	3	0	2	0	1	3	5	3	5	3	3	1	0	3	3	2	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:31635648G>C	uc003nvr.1	+	3	416	c.76G>C	c.(76-78)GAT>CAT	p.D26H	BAT4_uc003nvn.2_5'Flank|BAT4_uc003nvo.3_5'Flank|BAT4_uc003nvp.3_5'Flank|BAT4_uc003nvq.2_5'Flank|CSNK2B_uc010jta.1_Missense_Mutation_p.D26H|CSNK2B_uc003nvs.1_Missense_Mutation_p.D26H	NM_001320	NP_001311	P67870	CSK2B_HUMAN	casein kinase 2, beta polypeptide	26					adiponectin-mediated signaling pathway|axon guidance|cellular protein complex assembly|negative regulation of cell proliferation|regulation of DNA binding|Wnt receptor signaling pathway	cytosol|nucleus|protein kinase CK2 complex	identical protein binding|protein domain specific binding|protein kinase regulator activity|receptor binding|transcription factor binding				0						CTGACAGGTGGATGAAGACTA	0.458													13	20					0	0	0	0	C	31635648	C	C	31635648	3	2	258	1	0	0	0	0	1	0	0	0	3976	1174	41	2	82	2	CSNK2B	6	31635648	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08		31635648	139479419	37	46963											
GLO1	2739	broad.mit.edu	37	chr6	38670758	38670758	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtgcccaccttggtactggGgtccgcgtcggagcagcaac	6	8	14	13	3	0	0	0	0	0	0	2	1	1	1	3	4	5	3	3	4	2	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:38670758G>A	uc003ooc.2	-	1	195	c.73C>T	c.(73-75)CCC>TCC	p.P25S		NM_006708	NP_006699	Q04760	LGUL_HUMAN	glyoxalase I	25					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			ovary(1)	1					Glutathione(DB00143)	TTGGTACTGGGGTCCGCGTCG	0.711													3	23					0	0	0	0	A	38670758	A	A	38670758	3	1	258	1	0	0	0	0	1	0	0	0	6486	1232	43	4	505	4	GLO1	6	38670758	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	7035110	38670758	132444309	38	46964											
DNAH8	1769	broad.mit.edu	37	chr6	38704881	38704881	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggatgcgtcgaaaggactCttaaatggaattagggatat	13	11	12	5	2	1	0	0	0	1	0	2	5	1	4	0	4	1	0	0	4	6	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:38704881C>G	uc003ooe.1	+	4	750	c.150C>G	c.(148-150)CTC>CTG	p.L50L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CGAAAGGACTCTTAAATGGAA	0.398													5	83					0	0	0	0	G	38704881	G	G	38704881	2	3	258	1	0	0	0	0	0	0	0	1	4629	900	32	2		2	DNAH8	6	38704881	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	34123	38704881	132410186	39	46965											
SLC17A5	26503	broad.mit.edu	37	chr6	74331548	74331548	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcttgaacattgaaccttagGatctccttcatataagtagg	12	14	7	8	0	3	2	1	2	2	0	4	3	3	3	2	2	2	1	2	2	6	7	rs147732875		TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:74331548G>A	uc003phn.3	-	7	1085	c.957C>T	c.(955-957)ATC>ATT	p.I319I	SLC17A5_uc010kax.2_Intron|SLC17A5_uc010kay.2_RNA|SLC17A5_uc011dyo.1_Silent_p.I188I	NM_012434	NP_036566	Q9NRA2	S17A5_HUMAN	sialin	319					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			skin(5)|central_nervous_system(1)	6						TGAACCTTAGGATCTCCTTCA	0.313													9	21					0	0	0	0	A	74331548	A	A	74331548	2	1	258	1	0	0	0	0	0	0	0	1	14485	1164	41	2		2	SLC17A5	6	74331548	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08	35626667	74331548	96783519	40	46966											
C6orf174	387104	broad.mit.edu	37	chr6	127796911	127796911	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttcttgcccgcgtcgctctCggcgtcgctgtcgcgggggc	0	10	15	16	8	2	0	0	0	2	0	6	0	2	0	1	3	1	2	1	3	0	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:127796911C>T	uc003qbd.2	-	6	3125	c.2260G>A	c.(2260-2262)GAG>AAG	p.E754K	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	754						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		GCGTCGCTCTCGGCGTCGCTG	0.701													11	83					0	0	0	0	T	127796911	T	T	127796911	3	4	258	1	0	0	0	0	1	0	0	0	2355	893	31	1	591	1	C6orf174	6	127796911	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	53465363	127796911	43318156	41	46967											
C6orf97	80129	broad.mit.edu	37	chr6	151857487	151857487	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttcggaagtcccggtcaCgcgggagcagttaaaccact	9	9	11	12	4	2	0	1	0	1	0	4	2	3	2	2	3	2	2	2	3	3	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:151857487C>T	uc003qol.2	+	2	181	c.92C>T	c.(91-93)ACG>ATG	p.T31M		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	31	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		GTCCCGGTCACGCGGGAGCAG	0.433													5	57					0	0	0	0	T	151857487	T	T	151857487	3	4	258	1	0	0	0	0	1	0	0	0	2385	536	19	1	98	1	C6orf97	6	151857487	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	24060576	151857487	19257580	42	46968											
ZMIZ2	83637	broad.mit.edu	37	chr7	44805118	44805119	+	Frame_Shift_Ins	INS	-	C	C																															cgccctgggccccggcgctgINSccccctttgcccccctgcag																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:44805118_44805119insC	uc003tlr.2	+	16	2305_2306	c.2182_2183insC	c.(2182-2184)GCCfs	p.A728fs	ZMIZ2_uc003tlq.2_Frame_Shift_Ins_p.A670fs|ZMIZ2_uc003tls.2_Frame_Shift_Ins_p.A702fs|ZMIZ2_uc003tlt.2_Frame_Shift_Ins_p.A351fs|ZMIZ2_uc010kyj.2_Frame_Shift_Ins_p.A250fs|ZMIZ2_uc003tlu.2_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	728	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						CCCCGGCGCTGCCCCCTTTGCC	0.698													---	---	---								C	44805119	C	C	44805118	7	5	258	1	0	1	1	0	0	0	0	0	17764	1319	46	0	2240	0	ZMIZ2	7	44805118	Frame_Shift_Ins	INS	-	TCGA-CV-7423-01A-11D-2078-08		44805118	114333545	43	46969											
ELN	2006	broad.mit.edu	37	chr7	73474265	73474265	+	Silent	SNP	T	A	A																															ggagttggcgtggctcctggTgtcggtgtggctcctggagt																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:73474265T>A	uc003tzw.2	+	23	1573	c.1482T>A	c.(1480-1482)GGT>GGA	p.G494G	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Silent_p.G488G|ELN_uc003tzz.2_Silent_p.G407G|ELN_uc003tzo.2_Silent_p.G455G|ELN_uc003tzp.2_Silent_p.G399G|ELN_uc003tzq.2_Silent_p.G352G|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Silent_p.G469G|ELN_uc003tzt.2_Silent_p.G493G|ELN_uc003tzu.2_Silent_p.G474G|ELN_uc003tzv.2_Silent_p.G459G|ELN_uc003tzx.2_Silent_p.G478G|ELN_uc011kff.1_Silent_p.G488G|ELN_uc003tzy.2_Silent_p.G464G	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	517	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TGGCTCCTGGTGTCGGTGTGG	0.567			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						9	174					0	0	0	0	A	73474265	A	A	73474265	2	1	258	1	0	0	0	0	0	0	0	1	5095	1683	59	5		5	ELN	7	73474265	Silent	SNP	T	TCGA-CV-7423-01A-11D-2078-08	28669147	73474265	85664398	44	46970	101	2									
ELN	2006	broad.mit.edu	37	chr7	73474271	73474271	+	Silent	SNP	T	C	C																															ggcgtggctcctggtgtcggTgtggctcctggagttggctt																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:73474271T>C	uc003tzw.2	+	23	1579	c.1488T>C	c.(1486-1488)GGT>GGC	p.G496G	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Silent_p.G490G|ELN_uc003tzz.2_Silent_p.G409G|ELN_uc003tzo.2_Silent_p.G457G|ELN_uc003tzp.2_Silent_p.G401G|ELN_uc003tzq.2_Silent_p.G354G|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Silent_p.G471G|ELN_uc003tzt.2_Silent_p.G495G|ELN_uc003tzu.2_Silent_p.G476G|ELN_uc003tzv.2_Silent_p.G461G|ELN_uc003tzx.2_Silent_p.G480G|ELN_uc011kff.1_Silent_p.G490G|ELN_uc003tzy.2_Silent_p.G466G	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	519	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CTGGTGTCGGTGTGGCTCCTG	0.587			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						15	173					0	0	0	0	C	73474271	C	C	73474271	2	2	258	1	0	0	0	0	0	0	0	1	5095	1683	59	5		5	ELN	7	73474271	Silent	SNP	T	TCGA-CV-7423-01A-11D-2078-08	6	73474271	85664392	45	46971	101	2									
ACTL6B	51412	broad.mit.edu	37	chr7	100246281	100246281	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgccagaggggacttgacGatgcctagaaggaaggcact	11	6	14	10	1	0	3	0	1	0	2	0	6	0	5	3	4	2	1	3	4	3	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:100246281G>A	uc003uvy.2	-	7	674	c.567C>T	c.(565-567)ATC>ATT	p.I189I	ACTL6B_uc003uvx.1_5'UTR|ACTL6B_uc003uvz.2_RNA	NM_016188	NP_057272	O94805	ACL6B_HUMAN	actin-like 6B	189					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			ovary(1)	1	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GGGACTTGACGATGCCTAGAA	0.597													9	13					0	0	0	0	A	100246281	A	A	100246281	2	1	258	1	0	0	0	0	0	0	0	1	199	1048	37	1		1	ACTL6B	7	100246281	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08	26772010	100246281	58892382	46	46972											
MUC17	140453	broad.mit.edu	37	chr7	100678877	100678877	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaactcaaatcctagtgaaGgaaccactccgttaacaagt	16	8	6	11	1	1	1	1	1	0	0	3	2	3	2	3	1	3	1	3	1	7	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:100678877G>T	uc003uxp.1	+	3	4233	c.4180G>T	c.(4180-4182)GGA>TGA	p.G1394*	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1394	Extracellular (Potential).|59 X approximate tandem repeats.|21.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCTAGTGAAGGAACCACTCC	0.507													91	272					4.21773e-46	4.86661e-46	1	0	T	100678877	T	T	100678877	4	4	258	1	0	0	0	0	0	1	0	0	10027	1001	35	4	4190	4	MUC17	7	100678877	Nonsense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	432596	100678877	58459786	47	46973											
IMMP2L	83943	broad.mit.edu	37	chr7	110303748	110303748	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggggccacaggatatgtgtGgcatgggcatgcagaagtcc	9	7	17	8	0	0	1	0	0	0	1	1	2	1	2	2	5	1	3	2	5	2	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:110303748G>A	uc003vfq.1	-	6	881	c.438C>T	c.(436-438)GCC>GCT	p.A146A	IMMP2L_uc010ljr.1_Silent_p.A146A	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	146					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		GGATATGTGTGGCATGGGCAT	0.418													6	48					0	0	0	0	A	110303748	A	A	110303748	2	1	258	1	0	0	0	0	0	0	0	1	7756	1335	47	4		4	IMMP2L	7	110303748	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08	9624871	110303748	48834915	48	46974											
FBXO43	286151	broad.mit.edu	37	chr8	101149817	101149817	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatctgttttcagttgtgtGatataaaatttcctcctccg	9	17	7	8	1	2	1	1	1	1	0	5	2	5	1	3	0	0	2	3	0	4	6			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr8:101149817G>A	uc003yjd.2	-	3	2363	c.1650C>T	c.(1648-1650)ATC>ATT	p.I550I	FBXO43_uc003yje.2_Silent_p.I516I|FBXO43_uc010mbp.1_Silent_p.I550I	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	550					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TCAGTTGTGTGATATAAAATT	0.303													17	20					0	0	0	0	A	101149817	A	A	101149817	2	1	258	1	0	0	0	0	0	0	0	1	5784	1280	45	2		2	FBXO43	8	101149817	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08		101149817	45214205	49	46975											
UBR5	51366	broad.mit.edu	37	chr8	103309160	103309160	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacaaacccttgcacattccGtacaacaacacagtgactcc	14	7	5	15	1	0	1	0	1	0	0	2	2	2	1	3	0	5	2	3	0	4	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr8:103309160G>A	uc003ykr.1	-	28	3659	c.3626C>T	c.(3625-3627)ACG>ATG	p.T1209M	UBR5_uc003yks.1_Missense_Mutation_p.T1209M	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1209	UBR-type.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGCACATTCCGTACAACAACA	0.318													4	33					0	0	0	0	A	103309160	A	A	103309160	3	1	258	1	0	0	0	0	1	0	0	0	16973	1145	40	1	4901	1	UBR5	8	103309160	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	2159343	103309160	43054862	50	46976											
ZFAT	57623	broad.mit.edu	37	chr8	135620985	135620985	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actttacctgcttgacttcaTtggttgctcataaggtgtct	7	17	8	9	0	3	1	2	1	1	0	3	1	3	1	1	2	3	3	1	2	2	7			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr8:135620985T>C	uc003yup.2	-	5	947	c.772A>G	c.(772-774)ATG>GTG	p.M258V	ZFAT_uc003yun.2_Missense_Mutation_p.M246V|ZFAT_uc003yuo.2_Missense_Mutation_p.M246V|ZFAT_uc010meh.2_Missense_Mutation_p.M246V|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.M246V|ZFAT_uc010mej.2_Missense_Mutation_p.M196V|ZFAT_uc003yur.2_Missense_Mutation_p.M246V	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTTGACTTCATTGGTTGCTCA	0.483													52	42					0	0	0	0	C	135620985	C	C	135620985	3	2	258	1	0	0	0	0	1	0	0	0	17699	1493	52	5	3007	5	ZFAT	8	135620985	Missense_Mutation	SNP	T	TCGA-CV-7423-01A-11D-2078-08	32311825	135620985	10743037	51	46977											
ZC3H3	23144	broad.mit.edu	37	chr8	144589967	144589967	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agggcagagacagggggaagGgcggggcgctgagaggcgag	10	1	24	6	3	0	2	0	1	0	2	0	6	0	3	0	7	0	2	0	7	1	0			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr8:144589967G>C	uc003yyd.2	-	4	1693	c.1664C>G	c.(1663-1665)CCC>CGC	p.P555R		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	555					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CAGGGGGAAGGGCGGGGCGCT	0.667													32	45					0	0	0	0	C	144589967	C	C	144589967	3	2	258	1	0	0	0	0	1	0	0	0	17636	1232	43	4	1218	4	ZC3H3	8	144589967	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	8968982	144589967	1774055	52	46978											
DOCK8	81704	broad.mit.edu	37	chr9	446516	446517	+	Frame_Shift_Ins	INS	-	CA	CA																															ggcggcctcggggagagctgINScatgagcagtacagaaggaa																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr9:446516_446517insCA	uc003zgf.2	+	44	5839_5840	c.5727_5728insCA	c.(5725-5730)CTGCATfs	p.L1909fs	DOCK8_uc010mgu.2_Frame_Shift_Ins_p.L1211fs|DOCK8_uc010mgv.2_Frame_Shift_Ins_p.L1809fs|DOCK8_uc003zgk.2_Frame_Shift_Ins_p.L1367fs	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1909_1910					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GGGGAGAGCTGCATGAGCAGTA	0.545													---	---	---								CA	446517	CA	CA	446516	7	5	258	1	0	1	1	0	0	0	0	0	4715	1306	46	0	5901	0	DOCK8	9	446516	Frame_Shift_Ins	INS	-	TCGA-CV-7423-01A-11D-2078-08		446516	140766915	53	46979											
ACO1	48	broad.mit.edu	37	chr9	32423392	32423392	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcgagatttcaatgaccCttctcaagacccagacttca	11	12	6	12	1	3	4	3	1	1	3	5	5	3	4	2	0	0	1	2	0	2	4			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr9:32423392C>T	uc003zqw.3	+	9	1201	c.1046C>T	c.(1045-1047)CCT>CTT	p.P349L	ACO1_uc010mjh.1_Missense_Mutation_p.P183L|ACO1_uc003zqx.3_Missense_Mutation_p.P349L|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	349					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TTCAATGACCCTTCTCAAGAC	0.398													6	43					0	0	0	0	T	32423392	T	T	32423392	3	4	258	1	0	0	0	0	1	0	0	0	146	681	24	4	1076	4	ACO1	9	32423392	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	31976876	32423392	108790039	54	46980											
FLJ46321	389763	broad.mit.edu	37	chr9	84606915	84606923	+	In_Frame_Del	DEL	GCACAGCGA	-	-																															ttctggggtctcccatctttGcacagcgagtctctgcatcc																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr9:84606915_84606923delGCACAGCGA	uc004amn.2	+	4	1577_1585	c.1530_1538delGCACAGCGA	c.(1528-1539)TTGCACAGCGAG>TTG	p.HSE511del		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	511_513						integral to membrane					0						TCCCATCTTTGCACAGCGAGTCTCTGCAT	0.445													---	---	---								-	84606923	-	-	84606915	7	5	258	1	0	1	0	1	0	0	0	0	5964	1310	46	0	1544	0	FLJ46321	9	84606915	In_Frame_Del	DEL	GCACAGCGA	TCGA-CV-7423-01A-11D-2078-08	52183523	84606915	56606516	55	46981											
C9orf170	401535	broad.mit.edu	37	chr9	89771559	89771559	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaacttcaggagaaagtcTgatttaggagtcggaagccc	13	8	12	8	1	2	2	1	1	1	1	3	6	2	4	1	3	2	0	1	3	4	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr9:89771559T>C	uc004apa.1	+	2	327	c.240T>C	c.(238-240)TCT>TCC	p.S80S		NM_001001709	NP_001001709	A2RU37	CI170_HUMAN	hypothetical protein LOC401535	80											0						ggagaaagtctgatttaggag	0.124													4	20					0	0	0	0	C	89771559	C	C	89771559	2	2	258	1	0	0	0	0	0	0	0	1	2481	1567	55	5		5	C9orf170	9	89771559	Silent	SNP	T	TCGA-CV-7423-01A-11D-2078-08	5164644	89771559	51441872	56	46982											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112900135	112900135	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagggccgaggagaaggcGtctccaagtcatttagtgat	11	8	14	8	2	2	3	1	1	1	2	3	5	2	3	2	3	0	0	2	3	3	2	rs142423891		TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr9:112900135G>A	uc004bei.2	+	9	3199	c.3007G>A	c.(3007-3009)GTC>ATC	p.V1003I	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.V771I|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.V771I|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.V581I|AKAP2_uc011lwi.1_Missense_Mutation_p.V629I|AKAP2_uc004bem.2_Missense_Mutation_p.V629I|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.V589I|AKAP2_uc011lwj.1_Missense_Mutation_p.V540I|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.V540I	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	540							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AGGAGAAGGCGTCTCCAAGTC	0.532													5	46					0	0	0	0	A	112900135	A	A	112900135	3	1	258	1	0	0	0	0	1	0	0	0	11464	1145	40	1	2341	1	PALM2-AKAP2	9	112900135	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	23128576	112900135	28313296	57	46983											
UPF2	26019	broad.mit.edu	37	chr10	11973704	11973704	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctttttcattctcatcctCtcttcttgttctgcctgttg	3	21	5	12	0	5	0	2	0	4	0	8	0	6	0	2	0	2	3	2	0	0	7			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr10:11973704C>G	uc001ila.2	-	19	4098	c.3624G>C	c.(3622-3624)GAG>GAC	p.E1208D	UPF2_uc001ilb.2_Missense_Mutation_p.E1208D|UPF2_uc001ilc.2_Missense_Mutation_p.E1208D	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	1208	Sufficient for interaction with UPF1 C- terminus.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				TTCTCATCCTCTCTTCTTGTT	0.373													10	58					0	0	0	0	G	11973704	G	G	11973704	3	3	258	1	0	0	0	0	1	0	0	0	17072	912	32	2	206	2	UPF2	10	11973704	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08		11973704	123561043	58	46984											
CHST15	51363	broad.mit.edu	37	chr10	125804104	125804104	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccagcactcaccaaagcgcTtccgggtccaccagtgtggc	8	6	10	17	2	1	0	1	0	0	0	3	0	3	0	5	2	2	2	5	2	1	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr10:125804104T>C	uc001lhl.2	-	2	1391	c.878A>G	c.(877-879)AAG>AGG	p.K293R	CHST15_uc001lhm.2_Missense_Mutation_p.K293R|CHST15_uc001lhn.2_Missense_Mutation_p.K293R|CHST15_uc010que.1_Missense_Mutation_p.K293R|CHST15_uc001lho.2_Missense_Mutation_p.K293R	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	293	Lumenal (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						ACCAAAGCGCTTCCGGGTCCA	0.637													7	12					0	0	0	0	C	125804104	C	C	125804104	3	2	258	1	0	0	0	0	1	0	0	0	3418	1609	56	5	831	5	CHST15	10	125804104	Missense_Mutation	SNP	T	TCGA-CV-7423-01A-11D-2078-08	113830400	125804104	9730643	59	46985											
PHLDA2	7262	broad.mit.edu	37	chr11	2950579	2950579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgccctcgcgtagcacctCgtcgggggatttcatgtcgt	4	11	12	14	6	1	0	1	0	0	0	6	1	1	1	2	2	1	2	2	2	1	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:2950579C>T	uc001lxa.1	-	1	72	c.16G>A	c.(16-18)GAG>AAG	p.E6K		NM_003311	NP_003302	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain family A member	6					apoptosis	cytoplasm|membrane					0		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		CGTAGCACCTCGTCGGGGGAT	0.677													10	8					0	0	0	0	T	2950579	T	T	2950579	3	4	258	1	0	0	0	0	1	0	0	0	11904	893	31	1	446	1	PHLDA2	11	2950579	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08		2950579	132055937	60	46986											
HPX	3263	broad.mit.edu	37	chr11	6452604	6452604	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagggccaagggacttttccAtacacaaggctccgtctacc	10	9	9	13	1	1	0	0	0	1	0	3	1	3	1	4	3	2	1	4	3	5	5			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:6452604A>G	uc001mdg.2	-	10	1287	c.1226T>C	c.(1225-1227)ATG>ACG	p.M409T	HPX_uc001mdf.2_Missense_Mutation_p.M155T|HPX_uc009yfc.2_RNA	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	409					cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		GGACTTTTCCATACACAAGGC	0.562													15	34					0	0	0	0	G	6452604	G	G	6452604	3	3	258	1	0	0	0	0	1	0	0	0	7385	217	8	5	166	5	HPX	11	6452604	Missense_Mutation	SNP	A	TCGA-CV-7423-01A-11D-2078-08	3502025	6452604	128553912	61	46987											
TUB	7275	broad.mit.edu	37	chr11	8123160	8123160	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcgacagcaagctggcgtgCgagtagaggcctcttcgtgc	7	9	14	11	4	1	1	0	0	1	1	3	3	1	1	1	2	4	3	1	2	2	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:8123160C>T	uc001mga.2	+	12	1664	c.1515C>T	c.(1513-1515)TGC>TGT	p.C505C	TUB_uc010rbk.1_Silent_p.C511C|TUB_uc001mfy.2_Silent_p.C560C	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	505					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		AGCTGGCGTGCGAGTAGAGGC	0.597													15	8					0	0	0	0	T	8123160	T	T	8123160	2	4	258	1	0	0	0	0	0	0	0	1	16810	776	27	1		1	TUB	11	8123160	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	1670556	8123160	126883356	62	46988											
LPXN	9404	broad.mit.edu	37	chr11	58343413	58343414	+	5'Flank	INS	-	T	T																															tctcttttgatttggtgagcINSttttttttttttttcatagg																								rs11413202		TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-11A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	0d495571-2b44-458d-9c80-58a9e13d1ccc	g.chr11:58343413_58343414insT	uc001nmw.2	-						LPXN_uc009ymp.2_5'Flank|LPXN_uc010rkj.1_Intron|LPXN_uc010rkk.1_Intron	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2						cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				ATTTGGTGAGCTTTTTTTTTTT	0.386													---	---	---								T	58343414	T	T	58343413	6	5	258	0	1	1	1	0	0	0	0	0	8979	812	28	0		0	LPXN	11	58343413	5'Flank	INS	-	TCGA-CV-7423-01A-11D-2078-08	50220253	58343413	76663103	63	46989											
MS4A14	84689	broad.mit.edu	37	chr11	60170536	60170536	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagtagaactcttttcattgTaagtggtcttattttgcatg	9	18	8	6	0	3	1	1	0	2	1	3	1	3	1	0	1	2	3	0	1	4	8			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:60170536T>C	uc001npj.2	+	4	1033	c.468_splice	c.e4+2	p.I156_splice	MS4A14_uc001npi.2_Splice_Site_p.I44_splice|MS4A14_uc001npn.2_Splice_Site|MS4A14_uc001npk.2_Splice_Site_p.I139_splice|MS4A14_uc001npl.2_Splice_Site|MS4A14_uc001npm.2_Splice_Site	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity			breast(1)	1						CTTTTCATTGTAAGTGGTCTT	0.343													21	57					0	0	0	0	C	60170536	C	C	60170536	5	2	258	1	0	0	0	0	0	0	1	0	9911	1652	57	5	484	5	MS4A14	11	60170536	Splice_Site	SNP	T	TCGA-CV-7423-01A-11D-2078-08	1827123	60170536	74835980	64	46990											
MTA2	9219	broad.mit.edu	37	chr11	62361790	62361790	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatcagctgggtttagtttCtgacgcttggctgctggctg	4	14	14	9	1	2	1	1	1	1	0	2	1	2	1	0	3	2	8	0	3	1	4			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:62361790C>G	uc001ntq.1	-	17	2163	c.1782G>C	c.(1780-1782)CAG>CAC	p.Q594H	TUT1_uc001nto.2_5'Flank|MTA2_uc010rlx.1_Missense_Mutation_p.Q421H	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	594					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGTTTAGTTTCTGACGCTTGG	0.567													8	49					0	0	0	0	G	62361790	G	G	62361790	3	3	258	1	0	0	0	0	1	0	0	0	9962	912	32	2	232	2	MTA2	11	62361790	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	2191254	62361790	72644726	65	46991											
TBC1D10C	374403	broad.mit.edu	37	chr11	67172899	67172899	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgccggaaaggcatcccGtctgccctgcgcgcccgatg	6	6	13	16	5	1	0	0	0	1	0	2	2	2	1	4	2	3	1	4	2	1	0			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:67172899G>A	uc001ola.2	+	4	311	c.282G>A	c.(280-282)CCG>CCA	p.P94P	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_Silent_p.P94P|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	94	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			AAGGCATCCCGTCTGCCCTGC	0.657													13	38					0	0	0	0	A	67172899	A	A	67172899	2	1	258	1	0	0	0	0	0	0	0	1	15666	1132	40	1		1	TBC1D10C	11	67172899	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08	4811109	67172899	67833617	66	46992											
TPCN2	219931	broad.mit.edu	37	chr11	68822187	68822187	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatgtgacttttcgcttgtAgtaccgctccatcaaccacc	8	13	6	14	2	2	1	2	1	0	0	4	1	3	1	4	0	2	4	4	0	3	5			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:68822187A>G	uc001oos.2	+	3	291	c.175_splice	c.e3-2	p.Y59_splice	TPCN2_uc009ysk.1_Splice_Site|TPCN2_uc001oor.2_Intron|TPCN2_uc010rqg.1_Splice_Site_p.Y59_splice	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2						cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTTCGCTTGTAGTACCGCTCC	0.577													6	25					0	0	0	0	G	68822187	G	G	68822187	5	3	258	1	0	0	0	0	0	0	1	0	16463	434	15	5	183	5	TPCN2	11	68822187	Splice_Site	SNP	A	TCGA-CV-7423-01A-11D-2078-08	1649288	68822187	66184329	67	46993											
NFRKB	4798	broad.mit.edu	37	chr11	129748208	129748208	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acagtattgtactcacacccGagggacaggtgttgtggcat	10	10	12	9	1	1	0	1	0	0	0	1	2	1	1	1	3	1	4	1	3	2	4			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:129748208G>A	uc001qfi.2	-	15	1708	c.1507C>T	c.(1507-1509)CGG>TGG	p.R503W	NFRKB_uc001qfg.2_Missense_Mutation_p.R528W|NFRKB_uc001qfh.2_Missense_Mutation_p.R526W|NFRKB_uc010sbw.1_Silent_p.L513L	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	503					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		ACTCACACCCGAGGGACAGGT	0.433													19	20					0	0	0	0	A	129748208	A	A	129748208	3	1	258	1	0	0	0	0	1	0	0	0	10438	1057	37	1	2444	1	NFRKB	11	129748208	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	60926021	129748208	5258308	68	46994											
PUS7L	83448	broad.mit.edu	37	chr12	44130374	44130374	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcctggatacaaccttccTcggtcatgccaaagcggtgc	9	9	10	13	2	1	0	1	0	0	0	3	1	2	1	4	3	6	0	4	3	3	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr12:44130374T>A	uc001rnq.3	-	7	2024	c.1535A>T	c.(1534-1536)GAG>GTG	p.E512V	PUS7L_uc001rnr.3_Missense_Mutation_p.E512V|PUS7L_uc001rns.3_Missense_Mutation_p.E512V|PUS7L_uc009zkb.2_Missense_Mutation_p.E199V	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	512	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		ACAACCTTCCTCGGTCATGCC	0.448													12	50					0	0	0	0	A	44130374	A	A	44130374	3	1	258	1	0	0	0	0	1	0	0	0	12899	1551	54	5	582	5	PUS7L	12	44130374	Missense_Mutation	SNP	T	TCGA-CV-7423-01A-11D-2078-08		44130374	89721521	69	46995											
PUS7L	83448	broad.mit.edu	37	chr12	44148848	44148848	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctagttttggttttttgggAaaattatttggctcaagttg	8	20	10	3	0	2	0	1	0	1	0	2	1	2	1	0	3	0	4	0	3	5	9			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr12:44148848A>G	uc001rnq.3	-	2	690	c.201T>C	c.(199-201)TTT>TTC	p.F67F	PUS7L_uc001rnr.3_Silent_p.F67F|PUS7L_uc001rns.3_Silent_p.F67F|PUS7L_uc009zkb.2_Intron	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	67					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		GTTTTTTGGGAAAATTATTTG	0.323													4	52					0	0	0	0	G	44148848	G	G	44148848	2	3	258	1	0	0	0	0	0	0	0	1	12899	243	9	5		5	PUS7L	12	44148848	Silent	SNP	A	TCGA-CV-7423-01A-11D-2078-08	18474	44148848	89703047	70	46996											
EIF4B	1975	broad.mit.edu	37	chr12	53410391	53410391	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacggatgacctggaaggaGatggtaacttttcttttgtc	11	13	11	6	1	1	2	0	1	1	1	2	5	1	4	1	4	2	1	1	4	3	5			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr12:53410391G>C	uc001sbh.3	+	2	354	c.148G>C	c.(148-150)GAT>CAT	p.D50H	EIF4B_uc009zmp.1_RNA|EIF4B_uc010snu.1_Missense_Mutation_p.D50H|EIF4B_uc010snv.1_Missense_Mutation_p.D50H|EIF4B_uc001sbi.2_5'UTR	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	50					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						CCTGGAAGGAGATGGTAACTT	0.403													11	52					0	0	0	0	C	53410391	C	C	53410391	3	2	258	1	0	0	0	0	1	0	0	0	5051	942	33	2	154	2	EIF4B	12	53410391	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	9261543	53410391	80441504	71	46997											
VPS36	51028	broad.mit.edu	37	chr13	53007799	53007799	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagaatttaacagttacctCagaaatgtttttgtcagttt	12	16	6	7	0	2	2	2	0	0	2	2	2	2	2	2	0	2	3	2	0	4	6			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr13:53007799C>T	uc001vgs.2	-	6	560	c.526G>A	c.(526-528)GAG>AAG	p.E176K	VPS36_uc001vgq.2_Missense_Mutation_p.E118K	NM_016075	NP_057159	Q86VN1	VPS36_HUMAN	vacuolar protein sorting 36	176	Potential.				cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|late endosome|membrane|nucleus	lipid binding			skin(1)	1		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.14e-08)		ACAGTTACCTCAGAAATGTTT	0.343													3	41					0	0	0	0	T	53007799	T	T	53007799	3	4	258	1	0	0	0	0	1	0	0	0	17272	835	29	2	670	2	VPS36	13	53007799	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08		53007799	62162079	72	46998											
CMTM5	116173	broad.mit.edu	37	chr14	23847950	23847950	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actcagcaaaggtccagcccCagccctggcctggcttgacc	8	6	10	17	0	1	1	1	1	0	0	2	1	2	1	6	3	3	2	6	3	1	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr14:23847950C>T	uc010akm.2	+	3	796	c.352C>T	c.(352-354)CAG>TAG	p.Q118*	CMTM5_uc001wjs.2_Intron|CMTM5_uc001wjt.2_Intron|CMTM5_uc010akn.2_Intron|CMTM5_uc001wju.2_Intron|CMTM5_uc010ako.2_Intron	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	118	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		GGTCCAGCCCCAGCCCTGGCC	0.627													5	18					0	0	0	0	T	23847950	T	T	23847950	4	4	258	1	0	0	0	0	0	1	0	0	3601	609	21	4		4	CMTM5	14	23847950	Nonsense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08		23847950	83501590	73	46999											
TGM5	9333	broad.mit.edu	37	chr15	43545012	43545012	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtagcgcacgggctggcaGcctgtggcgttccactgctt	4	9	14	14	4	0	0	0	0	0	0	1	0	1	0	3	3	3	6	3	3	1	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:43545012G>C	uc001zrd.1	-	6	815	c.807C>G	c.(805-807)GGC>GGG	p.G269G	TGM5_uc001zre.1_Silent_p.G187G	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	269					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CGGGCTGGCAGCCTGTGGCGT	0.592													11	51					0	0	0	0	C	43545012	C	C	43545012	2	2	258	1	0	0	0	0	0	0	0	1	15899	958	34	4		4	TGM5	15	43545012	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08		43545012	58986380	74	47000											
CGNL1	84952	broad.mit.edu	37	chr15	57730854	57730854	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgacagctattcgtttatgCagctccgtggtcatagagga	9	12	12	8	2	1	2	1	1	0	1	3	3	2	3	1	2	3	4	1	2	3	5			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:57730854C>T	uc002aeg.2	+	2	733	c.657C>T	c.(655-657)TGC>TGT	p.C219C	CGNL1_uc010bfw.2_Silent_p.C219C	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	219	Head.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TTCGTTTATGCAGCTCCGTGG	0.527													18	128					0	0	0	0	T	57730854	T	T	57730854	2	4	258	1	0	0	0	0	0	0	0	1	3319	718	25	4		4	CGNL1	15	57730854	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	14185842	57730854	44800538	75	47001											
FAM63B	54629	broad.mit.edu	37	chr15	59064131	59064131	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggactctctggagtcgttCtctaacctgcattcttttcc	5	16	7	13	1	3	0	0	0	3	0	7	2	4	2	2	2	2	2	2	2	1	5			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:59064131C>T	uc002afj.2	+	1	739	c.537C>T	c.(535-537)TTC>TTT	p.F179F	FAM63B_uc002afi.2_Silent_p.F179F|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_RNA	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	hypothetical protein LOC54629 isoform a	179										central_nervous_system(1)	1						TGGAGTCGTTCTCTAACCTGC	0.647													11	19					0	0	0	0	T	59064131	T	T	59064131	2	4	258	1	0	0	0	0	0	0	0	1	5629	912	32	2		2	FAM63B	15	59064131	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	1333277	59064131	43467261	76	47002											
CORO2B	10391	broad.mit.edu	37	chr15	69003203	69003203	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaacaacatcctgttcagcGctggctacgactacaaggta	12	8	8	13	2	1	0	1	0	0	0	2	1	2	0	2	2	5	4	2	2	6	4			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:69003203G>A	uc002arj.3	+	4	495	c.466G>A	c.(466-468)GCT>ACT	p.A156T	CORO2B_uc010bic.2_Missense_Mutation_p.A151T|CORO2B_uc002ark.2_5'Flank	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	156	WD 2.				actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						CCTGTTCAGCGCTGGCTACGA	0.622													3	5					0	0	0	0	A	69003203	A	A	69003203	3	1	258	1	0	0	0	0	1	0	0	0	3772	1087	38	1	480	1	CORO2B	15	69003203	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	9939072	69003203	33528189	77	47003											
ISLR2	57611	broad.mit.edu	37	chr15	74426761	74426761	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgtcaacgcctactggttcCgcggcctgcggccgggtacc	4	7	14	16	6	1	0	1	0	0	0	2	0	2	0	5	4	4	2	5	4	3	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:74426761C>T	uc002axd.2	+	4	2435	c.1666C>T	c.(1666-1668)CGC>TGC	p.R556C	ISLR2_uc002axe.2_Missense_Mutation_p.R556C|ISLR2_uc010bjg.2_Missense_Mutation_p.R556C|ISLR2_uc010bjf.2_Missense_Mutation_p.R556C	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	556	Extracellular (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						CTACTGGTTCCGCGGCCTGCG	0.637													4	9					0	0	0	0	T	74426761	T	T	74426761	3	4	258	1	0	0	0	0	1	0	0	0	7898	652	23	1	1668	1	ISLR2	15	74426761	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	5423558	74426761	28104631	78	47004											
UBL7	84993	broad.mit.edu	37	chr15	74740855	74740855	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagaggcctgaagggcatgCtgtagggcttggctgaagag	9	7	17	8	0	0	4	0	2	0	2	0	4	0	4	2	4	1	5	2	4	3	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:74740855C>T	uc002axw.1	-	10	1131	c.969G>A	c.(967-969)CAG>CAA	p.Q323Q	UBL7_uc002axx.1_Silent_p.Q363Q|UBL7_uc010bjr.1_Silent_p.Q214Q|UBL7_uc002axy.1_Silent_p.Q323Q|UBL7_uc002axz.1_Silent_p.Q323Q	NM_032907	NP_116296	Q96S82	UBL7_HUMAN	ubiquitin-like 7	323							protein binding			ovary(1)	1						GAAGGGCATGCTGTAGGGCTT	0.542													23	106					0	0	0	0	T	74740855	T	T	74740855	2	4	258	1	0	0	0	0	0	0	0	1	16958	796	28	4		4	UBL7	15	74740855	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	314094	74740855	27790537	79	47005											
PKD1	5310	broad.mit.edu	37	chr16	2158547	2158547	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccggctcacgtccacgccGggcagggccacacgcgctgg	5	3	16	17	6	1	0	1	0	0	0	2	0	2	0	4	5	0	3	4	5	0	0			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr16:2158547G>A	uc002cos.1	-	15	6830	c.6621C>T	c.(6619-6621)CCC>CCT	p.P2207P	PKD1_uc002cot.1_Silent_p.P2207P	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2207	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CGTCCACGCCGGGCAGGGCCA	0.697													4	11					0	0	0	0	A	2158547	A	A	2158547	2	1	258	1	0	0	0	0	0	0	0	1	12018	1103	39	1		1	PKD1	16	2158547	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08		2158547	88196206	80	47006											
MVP	9961	broad.mit.edu	37	chr16	29851704	29851704	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgccatctgccaaagtggAggtggtggaggagcgccagg	8	7	18	8	1	1	0	0	0	1	0	1	3	1	3	3	6	3	0	3	6	1	0			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr16:29851704A>G	uc002dui.2	+	8	1199	c.1115A>G	c.(1114-1116)GAG>GGG	p.E372G	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010vdz.1_RNA|MVP_uc002duj.2_Missense_Mutation_p.E372G|MVP_uc010vea.1_5'UTR	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	372	MVP 7.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GCCAAAGTGGAGGTGGTGGAG	0.612													2	8					0	0	0	0	G	29851704	G	G	29851704	3	3	258	1	0	0	0	0	1	0	0	0	10049	304	11	5	1141	5	MVP	16	29851704	Missense_Mutation	SNP	A	TCGA-CV-7423-01A-11D-2078-08	27693157	29851704	60503049	81	47007											
ZNF423	23090	broad.mit.edu	37	chr16	49672378	49672378	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctggtggaggagaagccgcGcttgcacacagtgcacttga	9	7	15	10	2	0	2	0	1	0	1	0	4	0	3	1	3	3	4	1	3	1	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr16:49672378G>A	uc002efs.2	-	5	983	c.685C>T	c.(685-687)CGC>TGC	p.R229C	ZNF423_uc010vgn.1_Missense_Mutation_p.R112C	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	229	C2H2-type 5.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GAGAAGCCGCGCTTGCACACA	0.597													6	46					0	0	0	0	A	49672378	A	A	49672378	3	1	258	1	0	0	0	0	1	0	0	0	17965	1087	38	1	3189	1	ZNF423	16	49672378	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	19820674	49672378	40682375	82	47008											
KRTAP4-9	100132386	broad.mit.edu	37	chr17	39261988	39261988	+	Frame_Shift_Del	DEL	C	-	-																															tgtgagacgacctgctgccaCcctaggtgctgcatctccag																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr17:39261988delC	uc010wfp.1	+	1	348	c.348delC	c.(346-348)CACfs	p.H116fs		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	116	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].|18.					keratin filament					0						CCTGCTGCCACCCTAGGtgct	0.353													---	---	---								-	39261988	-	-	39261988	7	5	258	1	0	1	0	1	0	0	0	0	8597	506	18	0	350	0	KRTAP4-9	17	39261988	Frame_Shift_Del	DEL	C	TCGA-CV-7423-01A-11D-2078-08		39261988	41933222	83	47009											
ZNF516	9658	broad.mit.edu	37	chr18	74154962	74154962	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gccccggccggccctggtggGgctggggcctcgcctcagct	1	6	17	17	3	1	0	1	0	0	0	2	0	1	0	6	7	1	2	6	7	0	0			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr18:74154962G>A	uc010dqx.1	-	2	284	c.49C>T	c.(49-51)CCC>TCC	p.P17S	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GCCCTGGTGGGGCTGGGGCCT	0.692													7	4					0	0	0	0	A	74154962	A	A	74154962	3	1	258	1	0	0	0	0	1	0	0	0	18027	1232	43	4	3463	4	ZNF516	18	74154962	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08		74154962	3922286	84	47010											
CNN1	1264	broad.mit.edu	37	chr19	11651894	11651894	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccctcccctcgccccagctgGcccagaagtatgaccaccag	8	5	8	20	1	0	2	0	1	0	1	2	2	1	2	8	1	1	2	8	1	2	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:11651894G>A	uc002msc.1	+	2	231	c.67G>A	c.(67-69)GCC>ACC	p.A23T	CNN1_uc010xmb.1_5'UTR|CNN1_uc010xmc.1_5'UTR	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	23					actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						GCCCCAGCTGGCCCAGAAGTA	0.632													3	14					0	0	0	0	A	11651894	A	A	11651894	3	1	258	1	0	0	0	0	1	0	0	0	3624	1203	42	4	73	4	CNN1	19	11651894	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08		11651894	47477089	85	47011											
MAST1	22983	broad.mit.edu	37	chr19	12951871	12951871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgcccacttctcgtttgcctCctcccgaaggtgagtccctc	4	11	8	18	3	1	1	0	1	1	0	6	2	4	1	5	1	1	1	5	1	1	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:12951871C>T	uc002mvm.2	+	3	367	c.239C>T	c.(238-240)TCC>TTC	p.S80F	MAST1_uc002mvk.2_Missense_Mutation_p.S76F|MAST1_uc002mvl.2_Missense_Mutation_p.S80F	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	80					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						TCGTTTGCCTCCTCCCGAAGG	0.627													4	38					0	0	0	0	T	12951871	T	T	12951871	3	4	258	1	0	0	0	0	1	0	0	0	9377	855	30	2	249	2	MAST1	19	12951871	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	1299977	12951871	46177112	86	47012											
EMR3	84658	broad.mit.edu	37	chr19	14752358	14752358	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggagaaaagtgagggccGccaggaggaggcacagcaga	15	1	17	8	1	0	3	0	1	0	2	0	6	0	5	2	5	1	2	2	5	2	0	rs146538980	by1000genomes	TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:14752358G>T	uc002mzi.3	-	10	1269	c.1121C>A	c.(1120-1122)GCG>GAG	p.A374E	EMR3_uc010dzp.2_Missense_Mutation_p.A322E|EMR3_uc010xnv.1_Missense_Mutation_p.A248E	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	374	Helical; Name=1; (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						AGTGAGGGCCGCCAGGAGGAG	0.582													8	37					2.17888e-05	2.37696e-05	1	0	T	14752358	T	T	14752358	3	4	258	1	0	0	0	0	1	0	0	0	5130	1087	38	3	865	3	EMR3	19	14752358	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	1800487	14752358	44376625	87	47013											
HAUS8	93323	broad.mit.edu	37	chr19	17163638	17163638	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcattttccgaggtaccttCggagctcaaggtcctttttc	7	14	9	11	2	1	0	1	0	0	0	5	2	3	1	3	3	3	3	3	3	2	6			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:17163638C>T	uc002nfe.2	-	10	1037	c.926G>A	c.(925-927)CGA>CAA	p.R309Q	HAUS8_uc002nff.2_Missense_Mutation_p.R308Q|HAUS8_uc002nfg.1_Missense_Mutation_p.R248Q|HAUS8_uc002nfh.1_Missense_Mutation_p.R309Q	NM_033417	NP_219485	Q9BT25	HAUS8_HUMAN	sarcoma antigen NY-SAR-48 isoform a	309					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0						GAGGTACCTTCGGAGCTCAAG	0.527											OREG0025339	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	80					0	0	0	0	T	17163638	T	T	17163638	3	4	258	1	0	0	0	0	1	0	0	0	7011	884	31	1	314	1	HAUS8	19	17163638	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	2411280	17163638	41965345	88	47014											
SFRS16	11129	broad.mit.edu	37	chr19	45555410	45555410	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcagtcgccctggccgctGagagccctgttaatatgtaa	8	10	11	12	2	0	1	0	1	0	1	1	2	0	1	3	1	2	4	3	1	3	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:45555410G>C	uc002pak.2	+	3	279	c.181G>C	c.(181-183)GAG>CAG	p.E61Q	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Intron|SFRS16_uc002pam.2_Missense_Mutation_p.E61Q|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	61					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCTGGCCGCTGAGAGCCCTGT	0.562													4	49					0	0	0	0	C	45555410	C	C	45555410	3	2	258	1	0	0	0	0	1	0	0	0	14237	1291	45	2	187	2	SFRS16	19	45555410	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	28391772	45555410	13573573	89	47015											
GPR4	2828	broad.mit.edu	37	chr19	46094975	46094975	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcaggtagacgcccagctcGttgcgctgttgcacctggcg	6	9	13	13	4	1	1	1	0	0	1	2	1	1	1	2	2	3	6	2	2	1	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:46094975G>A	uc002pcm.2	-	2	1095	c.150C>T	c.(148-150)AAC>AAT	p.N50N	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	50	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		CGCCCAGCTCGTTGCGCTGTT	0.617													18	46					0	0	0	0	A	46094975	A	A	46094975	2	1	258	1	0	0	0	0	0	0	0	1	6732	1136	40	1		1	GPR4	19	46094975	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08	539565	46094975	13034008	90	47016											
LILRA1	11024	broad.mit.edu	37	chr19	55106360	55106360	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcggtatcgctgtttctacGgtagccacactgcaggctgg	6	10	14	11	3	1	0	0	0	1	0	2	0	1	0	1	5	3	6	1	5	3	4			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:55106360G>A	uc002qgh.1	+	4	483	c.301G>A	c.(301-303)GGT>AGT	p.G101S	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.G101S	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	101	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CTGTTTCTACGGTAGCCACAC	0.607													11	52					0	0	0	0	A	55106360	A	A	55106360	3	1	258	1	0	0	0	0	1	0	0	0	8825	1116	39	1	311	1	LILRA1	19	55106360	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	9011385	55106360	4022623	91	47017											
ProSAPiP1	9762	broad.mit.edu	37	chr20	3146179	3146179	+	Frame_Shift_Del	DEL	G	-	-																															tctatccggggcaggaagtcGgcctgctccttctggcaggc																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr20:3146179delG	uc002wia.1	-	2	2685	c.1287delC	c.(1285-1287)GCCfs	p.A429fs	ProSAPiP1_uc002wib.1_Frame_Shift_Del_p.A383fs	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	429	Potential.					cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						GCAGGAAGTCGGCCTGCTCCT	0.662													---	---	---								-	3146179	-	-	3146179	7	5	258	1	0	1	0	1	0	0	0	0	12935	1103	39	0	742	0	ProSAPiP1	20	3146179	Frame_Shift_Del	DEL	G	TCGA-CV-7423-01A-11D-2078-08		3146179	59879341	92	47018											
ISM1	140862	broad.mit.edu	37	chr20	13279972	13279972	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccactacaaggtggacgtcCtgccctggattatctgcaag	9	10	10	12	1	1	0	0	0	1	0	3	2	3	2	3	3	3	1	3	3	4	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr20:13279972C>T	uc010gce.1	+	6	1267	c.1261C>T	c.(1261-1263)CTG>TTG	p.L421L	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	421	AMOP.					extracellular region					0						GGTGGACGTCCTGCCCTGGAT	0.622													5	21					0	0	0	0	T	13279972	T	T	13279972	2	4	258	1	0	0	0	0	0	0	0	1	7899	680	24	4		4	ISM1	20	13279972	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	10133793	13279972	49745548	93	47019											
PCK1	5105	broad.mit.edu	37	chr20	56137828	56137828	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagatcggcatcgagctgacGgattcaccctacgtggtggc	9	8	13	11	4	1	2	1	1	0	1	3	4	1	3	1	4	2	2	1	4	2	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr20:56137828G>A	uc002xyn.3	+	4	646	c.483G>A	c.(481-483)ACG>ACA	p.T161T	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	161					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TCGAGCTGACGGATTCACCCT	0.612													4	46					0	0	0	0	A	56137828	A	A	56137828	2	1	258	1	0	0	0	0	0	0	0	1	11635	1103	39	1		1	PCK1	20	56137828	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08	42857856	56137828	6887692	94	47020											
PRIC285	85441	broad.mit.edu	37	chr20	62192986	62192986	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttcggcctcccctcccggggGctcttcctgagcagcttcct	2	11	10	18	2	1	1	0	1	1	0	6	1	5	1	6	3	2	3	6	3	0	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr20:62192986G>A	uc002yfm.2	-	13	7696	c.6804C>T	c.(6802-6804)AGC>AGT	p.S2268S	PRIC285_uc002yfl.1_Silent_p.S1699S	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	2268					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CCTCCCGGGGGCTCTTCCTGA	0.657													42	62					0	0	0	0	A	62192986	A	A	62192986	2	1	258	1	0	0	0	0	0	0	0	1	12547	1194	42	4		4	PRIC285	20	62192986	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08	6055158	62192986	832534	95	47021											
CECR5	27440	broad.mit.edu	37	chr22	17619607	17619607	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taaatggtttccaggcacagCagaaaggtgccatgtccaaa	14	8	10	9	0	0	1	0	0	0	1	2	1	2	1	3	3	2	3	3	3	4	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr22:17619607C>A	uc002zmf.2	-	7	796	c.768G>T	c.(766-768)CTG>CTT	p.L256L	CECR5_uc002zmd.2_Silent_p.L67L|CECR5_uc002zme.2_Silent_p.L48L|CECR5_uc002zmg.2_Intron|CECR5_uc002zmh.2_Silent_p.L226L	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	256							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				CCAGGCACAGCAGAAAGGTGC	0.537													13	121					9.31168e-06	1.03463e-05	1	0	A	17619607	A	A	17619607	2	1	258	1	0	0	0	0	0	0	0	1	3222	697	25	4		4	CECR5	22	17619607	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08		17619607	33684959	96	47022											
PISD	23761	broad.mit.edu	37	chr22	32017676	32017676	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggccgggcctgcggcttcaGcttgcgccggaagaactcgc	6	6	15	14	5	1	1	1	0	0	1	2	2	1	2	3	4	4	2	3	4	2	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr22:32017676G>A	uc003alm.3	-	4	524	c.517C>T	c.(517-519)CTG>TTG	p.L173L	PISD_uc003alk.2_Silent_p.L139L|PISD_uc003all.2_Silent_p.L138L|PISD_uc011alr.1_Silent_p.L138L|PISD_uc003aln.3_Silent_p.L173L	NM_014338	NP_055153	Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	173					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)	TGCGGCTTCAGCTTGCGCCGG	0.602													5	29					0	0	0	0	A	32017676	A	A	32017676	2	1	258	1	0	0	0	0	0	0	0	1	12001	962	34	4		4	PISD	22	32017676	Silent	SNP	G	TCGA-CV-7423-01A-11D-2078-08	14398069	32017676	19286890	97	47023											
KCNJ4	3761	broad.mit.edu	37	chr22	38823814	38823814	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcagggcttgggggccacCggggctgctccgccaccacc	5	5	15	16	2	0	0	0	0	0	0	1	0	1	0	6	5	2	4	6	5	0	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr22:38823814C>T	uc003avs.1	-	2	421	c.324G>A	c.(322-324)CCG>CCA	p.P108P	KCNJ4_uc003avt.1_Silent_p.P108P	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	108	Val/Gly/Ala/Pro stretch.|Extracellular (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					TGGGGGCCACCGGGGCTGCTC	0.577													15	23					0	0	0	0	T	38823814	T	T	38823814	2	4	258	1	0	0	0	0	0	0	0	1	8092	639	23	1		1	KCNJ4	22	38823814	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	6806138	38823814	12480752	98	47024											
ZC3H7B	23264	broad.mit.edu	37	chr22	41752804	41752804	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccatgggcgagttccggctCtgcgacaggtgctcctggga	5	8	15	13	3	1	0	0	0	1	0	3	3	3	1	3	4	2	3	3	4	0	1			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr22:41752804C>G	uc003azw.2	+	22	2889	c.2673C>G	c.(2671-2673)CTC>CTG	p.L891L	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	907	C3H1-type 4.				interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						AGTTCCGGCTCTGCGACAGGT	0.667													7	39					0	0	0	0	G	41752804	G	G	41752804	2	3	258	1	0	0	0	0	0	0	0	1	17640	900	32	2		2	ZC3H7B	22	41752804	Silent	SNP	C	TCGA-CV-7423-01A-11D-2078-08	2928990	41752804	9551762	99	47025											
FBLN1	2192	broad.mit.edu	37	chr22	45929029	45929029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctaccagctgctgtctgatGgtgtctcctgtgaaggtaat	7	13	12	9	0	2	2	0	2	2	0	3	2	2	2	2	2	3	4	2	2	3	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr22:45929029G>C	uc003bgj.1	+	6	778	c.631G>C	c.(631-633)GGT>CGT	p.G211R	FBLN1_uc003bgg.1_Missense_Mutation_p.G211R|FBLN1_uc003bgh.2_Missense_Mutation_p.G211R|FBLN1_uc010gzz.2_Missense_Mutation_p.G249R|FBLN1_uc003bgi.1_Missense_Mutation_p.G211R	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	211	EGF-like 1.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GCTGTCTGATGGTGTCTCCTG	0.637													8	35					0	0	0	0	C	45929029	C	C	45929029	3	2	258	1	0	0	0	0	1	0	0	0	5730	1348	47	4	653	4	FBLN1	22	45929029	Missense_Mutation	SNP	G	TCGA-CV-7423-01A-11D-2078-08	4176225	45929029	5375537	100	47026											
RBBP7	5931	broad.mit.edu	37	chrX	16887232	16887232	+	Missense_Mutation	SNP	C	A	A																															gaagccactgaacggtaagaCtgggccactgaagagcatgg																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chrX:16887232C>A	uc004cxt.2	-	2	486	c.128G>T	c.(127-129)AGT>ATT	p.S43I	RBBP7_uc004cxs.1_Missense_Mutation_p.S87I|RBBP7_uc004cxu.2_Missense_Mutation_p.S43I	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	43					cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					AACGGTAAGACTGGGCCACTG	0.403													8	28					1.12685e-05	1.24057e-05	1	0	A	16887232	A	A	16887232	3	1	258	1	0	0	0	0	1	0	0	0	13169	565	20	4	1193	4	RBBP7	23	16887232	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08		16887232	138383328	101	47027	102	2									
RBBP7	5931	broad.mit.edu	37	chrX	16887237	16887237	+	Missense_Mutation	SNP	C	G	G																															cactgaacggtaagactgggCcactgaagagcatgggtcat																										TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chrX:16887237C>G	uc004cxt.2	-	2	481	c.123G>C	c.(121-123)TGG>TGC	p.W41C	RBBP7_uc004cxs.1_Missense_Mutation_p.W85C|RBBP7_uc004cxu.2_Missense_Mutation_p.W41C	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	41					cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					TAAGACTGGGCCACTGAAGAG	0.393													10	27					0	0	0	0	G	16887237	G	G	16887237	3	3	258	1	0	0	0	0	1	0	0	0	13169	740	26	4	1198	4	RBBP7	23	16887237	Missense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	5	16887237	138383323	102	47028	102	2									
DGKK	139189	broad.mit.edu	37	chrX	50119144	50119144	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacagacacatgctggtggAtcttgctcaggtcattaagt	10	11	12	8	0	3	1	2	0	1	1	3	3	3	3	0	4	2	2	0	4	1	2			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chrX:50119144A>T	uc010njr.1	-	25	3353	c.3293T>A	c.(3292-3294)ATC>AAC	p.I1098N		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	1098					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					ATGCTGGTGGATCTTGCTCAG	0.478													6	4					0	0	0	0	T	50119144	T	T	50119144	3	4	258	1	0	0	0	0	1	0	0	0	4494	333	12	5	542	5	DGKK	23	50119144	Missense_Mutation	SNP	A	TCGA-CV-7423-01A-11D-2078-08	33231907	50119144	105151416	103	47029											
KLHL4	56062	broad.mit.edu	37	chrX	86877396	86877396	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggggatgctgctttcttaCatcagactgccattactccc	7	13	8	13	0	2	1	1	0	1	1	3	2	3	2	2	2	5	2	2	2	2	3			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chrX:86877396C>A	uc004efb.2	+	5	1292	c.1110C>A	c.(1108-1110)TAC>TAA	p.Y370*	KLHL4_uc004efa.2_Nonsense_Mutation_p.Y370*	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	370						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TGCTTTCTTACATCAGACTGC	0.413													10	34					0.00010058	0.000107764	1	0	A	86877396	A	A	86877396	4	1	258	1	0	0	0	0	0	1	0	0	8430	489	17	4	1128	4	KLHL4	23	86877396	Nonsense_Mutation	SNP	C	TCGA-CV-7423-01A-11D-2078-08	36758252	86877396	68393164	104	47030											
KLHDC7A	127707	broad.mit.edu	37	chr1	18808991	18808991	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgccccaaggaagactccGgcggcctctgttgctatgac	7	9	12	13	2	1	2	0	1	1	1	2	3	2	3	4	3	2	2	4	3	3	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:18808991G>A	uc001bax.2	+	1	1568	c.1516G>A	c.(1516-1518)GGC>AGC	p.G506S	KLHDC7A_uc009vpg.2_Missense_Mutation_p.G288S	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	506	Kelch 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGAAGACTCCGGCGGCCTCTG	0.697													14	53					0	0	0	0	A	18808991	A	A	18808991	3	1	259	1	0	0	0	0	1	0	0	0	8399	1116	39	1	1518	1	KLHDC7A	1	18808991	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		18808991	230441630	1	47031											
ZMYM4	9202	broad.mit.edu	37	chr1	35881288	35881288	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catatctgaggttcttcccaCctttacagaagcaggagtca	11	11	8	11	0	3	2	1	1	2	1	4	3	4	3	2	2	2	2	2	2	3	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:35881288C>T	uc001byt.2	+	28	4362	c.4282C>T	c.(4282-4284)CCT>TCT	p.P1428S	ZMYM4_uc009vuu.2_Missense_Mutation_p.P1396S|ZMYM4_uc001byu.2_Missense_Mutation_p.P1104S|ZMYM4_uc009vuv.2_Missense_Mutation_p.P1167S	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	1428					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTTCTTCCCACCTTTACAGAA	0.428													22	27					0	0	0	0	T	35881288	T	T	35881288	3	4	259	1	0	0	0	0	1	0	0	0	17769	507	18	4	4392	4	ZMYM4	1	35881288	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	17072297	35881288	213369333	2	47032											
LRP8	7804	broad.mit.edu	37	chr1	53746315	53746316	+	Frame_Shift_Ins	INS	-	A	A																															gtccttctccccgtcgcagcINSgccacgaggcaggtacacac																								rs146690956		TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:53746315_53746316insA	uc001cvi.1	-	4	581_582	c.439_440insT	c.(439-441)CGCfs	p.R147fs	LRP8_uc001cvh.1_5'UTR|LRP8_uc001cvk.1_Frame_Shift_Ins_p.R147fs|LRP8_uc001cvj.1_Frame_Shift_Ins_p.R147fs|LRP8_uc001cvl.1_Frame_Shift_Ins_p.R147fs	NM_004631	NP_004622	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein	147	LDL-receptor class A 3.|Extracellular (Potential).				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0						CCCGTCGCAGCGCCACGAGGCA	0.614													---	---	---								A	53746316	A	A	53746315	7	5	259	1	0	1	1	0	0	0	0	0	9013	768	27	0	2515	0	LRP8	1	53746315	Frame_Shift_Ins	INS	-	TCGA-CV-7424-01A-11D-2078-08	17865027	53746315	195504306	3	47033											
ACADM	34	broad.mit.edu	37	chr1	76205698	76205698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaacctggagcaggctctGatgtagctggtataaagacc	12	8	12	9	0	1	3	0	1	1	2	1	4	1	4	2	3	3	5	2	3	5	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:76205698G>A	uc001dgw.3	+	7	932	c.502G>A	c.(502-504)GAT>AAT	p.D168N	ACADM_uc010orc.1_3'UTR|ACADM_uc010ord.1_Missense_Mutation_p.D82N|ACADM_uc009wbp.2_Missense_Mutation_p.D172N|ACADM_uc009wbr.2_Missense_Mutation_p.D201N|ACADM_uc010ore.1_Missense_Mutation_p.D132N|ACADM_uc010orf.1_5'UTR|ACADM_uc001dgx.3_Missense_Mutation_p.D82N|ACADM_uc010org.1_Missense_Mutation_p.D38N	NM_000016	NP_000007	P11310	ACADM_HUMAN	medium-chain acyl-CoA dehydrogenase isoform a	168					carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4						AGCAGGCTCTGATGTAGCTGG	0.338													12	16					0	0	0	0	A	76205698	A	A	76205698	3	1	259	1	0	0	0	0	1	0	0	0	113	1290	45	2	540	2	ACADM	1	76205698	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	22459383	76205698	173044923	4	47034											
ELTD1	64123	broad.mit.edu	37	chr1	79357299	79357299	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagctgtaaccactgatgcGtgcacaacatggagaacccc	13	7	9	12	1	0	2	0	1	0	1	0	3	0	2	3	1	6	3	3	1	4	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:79357299G>A	uc001diq.3	-	14	2076	c.1920C>T	c.(1918-1920)CAC>CAT	p.H640H		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	640	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CCACTGATGCGTGCACAACAT	0.448													11	19					0	0	0	0	A	79357299	A	A	79357299	2	1	259	1	0	0	0	0	0	0	0	1	5108	1136	40	1		1	ELTD1	1	79357299	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	3151601	79357299	169893322	5	47035											
HIPK1	204851	broad.mit.edu	37	chr1	114499787	114499787	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catggagatctgcaagcggaGggttcacatgtatgatacag	12	9	13	7	1	2	2	1	1	1	1	2	4	2	3	0	3	3	3	0	3	3	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:114499787G>A	uc001eem.2	+	7	1795	c.1634G>A	c.(1633-1635)AGG>AAG	p.R545K	HIPK1_uc001eel.2_Missense_Mutation_p.R545K|HIPK1_uc001een.2_Missense_Mutation_p.R545K|HIPK1_uc001eeo.2_Missense_Mutation_p.R171K|HIPK1_uc001eep.2_Missense_Mutation_p.R151K	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	545					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGCAAGCGGAGGGTTCACATG	0.388													15	28					0	0	0	0	A	114499787	A	A	114499787	3	1	259	1	0	0	0	0	1	0	0	0	7155	1000	35	4	1674	4	HIPK1	1	114499787	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	35142488	114499787	134750834	6	47036											
TDRKH	11022	broad.mit.edu	37	chr1	151751319	151751319	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcagtcggctccatgctaGaactggtgtttttccataat	8	14	10	9	1	0	1	0	0	0	1	3	1	2	1	2	2	3	4	2	2	3	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:151751319G>C	uc009wnb.1	-	6	907	c.725C>G	c.(724-726)TCT>TGT	p.S242C	TDRKH_uc001eyy.2_Missense_Mutation_p.S18C|TDRKH_uc001ezb.3_Missense_Mutation_p.S238C|TDRKH_uc001ezc.3_Missense_Mutation_p.S197C|TDRKH_uc001eza.3_Missense_Mutation_p.S242C|TDRKH_uc001ezd.3_Missense_Mutation_p.S242C|TDRKH_uc010pdn.1_Missense_Mutation_p.S18C	NM_006862	NP_006853	Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing isoform a	242							RNA binding			ovary(1)|pancreas(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTCCATGCTAGAACTGGTGTT	0.542													16	93					0	0	0	0	C	151751319	C	C	151751319	3	2	259	1	0	0	0	0	1	0	0	0	15803	942	33	2	992	2	TDRKH	1	151751319	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	37251532	151751319	97499302	7	47037											
SPTA1	6708	broad.mit.edu	37	chr1	158612629	158612629	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgttagtggcgtctttgtagGattcatcacaggctgtgggc	6	14	14	7	1	3	0	2	0	1	0	3	1	3	1	0	4	0	3	0	4	2	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:158612629G>T	uc001fst.1	-	32	4779	c.4580C>A	c.(4579-4581)TCC>TAC	p.S1527Y		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1527	Spectrin 15.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GTCTTTGTAGGATTCATCACA	0.443													35	90					1.04594e-18	1.18602e-18	1	0	T	158612629	T	T	158612629	3	4	259	1	0	0	0	0	1	0	0	0	15182	1174	41	2	2763	2	SPTA1	1	158612629	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	6861310	158612629	90637992	8	47038											
DNM3	26052	broad.mit.edu	37	chr1	172356476	172356476	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccccctccagtggatgaCtcctggatacagcactctcg	8	8	9	16	1	1	1	0	1	1	0	4	3	3	3	4	2	2	2	4	2	1	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:172356476C>T	uc001gie.2	+	19	2438	c.2262C>T	c.(2260-2262)GAC>GAT	p.D754D	DNM3_uc001gif.2_Silent_p.D750D|DNM3_uc001gih.1_Silent_p.D110D	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	760					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						CAGTGGATGACTCCTGGATAC	0.383													6	14					0	0	0	0	T	172356476	T	T	172356476	2	4	259	1	0	0	0	0	0	0	0	1	4695	564	20	4		4	DNM3	1	172356476	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	13743847	172356476	76894145	9	47039											
RGL1	23179	broad.mit.edu	37	chr1	183891440	183891440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagaccccgccgaggagtacGagctggtgcaggtcatctcg	8	6	14	13	4	2	1	1	0	1	1	3	4	2	2	3	3	3	3	3	3	1	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:183891440G>A	uc001gqo.2	+	17	2246	c.2089G>A	c.(2089-2091)GAG>AAG	p.E697K	RGL1_uc001gqm.2_Missense_Mutation_p.E732K|RGL1_uc010pog.1_Missense_Mutation_p.E695K|RGL1_uc010poh.1_Missense_Mutation_p.E695K|RGL1_uc010poi.1_Missense_Mutation_p.E668K	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	697	Ras-associating.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						CGAGGAGTACGAGCTGGTGCA	0.572											OREG0014047	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	15					0	0	0	0	A	183891440	A	A	183891440	3	1	259	1	0	0	0	0	1	0	0	0	13341	1059	37	1	2260	1	RGL1	1	183891440	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	11534964	183891440	65359181	10	47040											
TPR	7175	broad.mit.edu	37	chr1	186310164	186310164	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttaactgcatttacctggTtacgtgctttccaacgtttg	7	18	7	9	2	0	0	0	0	0	0	1	0	1	0	2	1	6	4	2	1	4	7			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:186310164T>C	uc001grv.2	-	29	4313	c.4016A>G	c.(4015-4017)AAC>AGC	p.N1339S		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1339	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		ATTTACCTGGTTACGTGCTTT	0.393			T	NTRK1	papillary thyroid								19	82					0	0	0	0	C	186310164	C	C	186310164	3	2	259	1	0	0	0	0	1	0	0	0	16483	1725	60	5	3167	5	TPR	1	186310164	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	2418724	186310164	62940457	11	47041											
RGS21	431704	broad.mit.edu	37	chr1	192321331	192321331	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgaattcattgaagctgaTgcacctaaagaggtgagtga	13	11	11	6	0	2	6	1	5	1	1	2	6	2	6	1	1	2	2	1	1	4	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:192321331T>C	uc001gsh.2	+	4	417	c.243T>C	c.(241-243)GAT>GAC	p.D81D		NM_001039152	NP_001034241	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	81	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2						TTGAAGCTGATGCACCTAAAG	0.378													8	29					0	0	0	0	C	192321331	C	C	192321331	2	2	259	1	0	0	0	0	0	0	0	1	13369	1461	51	5		5	RGS21	1	192321331	Silent	SNP	T	TCGA-CV-7424-01A-11D-2078-08	6011167	192321331	56929290	12	47042											
PLEKHA6	22874	broad.mit.edu	37	chr1	204228389	204228389	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccggcatgcctcacctcCgaaggtcttcaggcgggggt	5	7	14	15	4	3	0	2	0	1	0	4	1	4	0	5	5	1	1	5	5	1	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:204228389C>T	uc001hau.2	-	8	1321	c.1004G>A	c.(1003-1005)CGG>CAG	p.R335Q	PLEKHA6_uc009xaw.1_5'Flank|PLEKHA6_uc009xax.1_5'Flank|PLEKHA6_uc009xay.1_5'Flank|PLEKHA6_uc009xaz.1_5'Flank|PLEKHA6_uc009xba.1_5'Flank|PLEKHA6_uc009xbb.1_5'Flank|PLEKHA6_uc009xbc.1_5'Flank	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	335	Pro-rich.									ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GCCTCACCTCCGAAGGTCTTC	0.617													5	23					0	0	0	0	T	204228389	T	T	204228389	3	4	259	1	0	0	0	0	1	0	0	0	12115	652	23	1	2202	1	PLEKHA6	1	204228389	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	11907058	204228389	45022232	13	47043											
RYR2	6262	broad.mit.edu	37	chr1	237664039	237664039	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcgtactgtaagctcaccAaaccaacatctgttaagaac	14	9	6	12	1	2	1	1	0	1	1	3	1	2	1	2	0	5	5	2	0	6	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:237664039A>G	uc001hyl.1	+	21	2352	c.2232A>G	c.(2230-2232)CCA>CCG	p.P744P		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	744	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TAAGCTCACCAAACCAACATC	0.413													56	184					0	0	0	0	G	237664039	G	G	237664039	2	3	259	1	0	0	0	0	0	0	0	1	13834	117	5	5		5	RYR2	1	237664039	Silent	SNP	A	TCGA-CV-7424-01A-11D-2078-08	33435650	237664039	11586582	14	47044											
SDCCAG8	10806	broad.mit.edu	37	chr1	243437866	243437867	+	Missense_Mutation	DNP	AC	TT	TT																															ggtcattagaacatgaggaaAccaatatgcctactatgcac																										TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:243437866_243437867AC>TT	uc001hzw.2	+	4	484_485	c.328_329AC>TT	c.(328-330)ACC>TTC	p.T110F	SDCCAG8_uc010pyk.1_Intron|SDCCAG8_uc010pyl.1_Intron	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	110					establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		ACATGAGGAAACCAATATGCCT	0.287													6	35					0	0	0	0	TT	243437867	TT	TT	243437866	3	4	259	1	0	0	0	0	1	0	0	0	14024	43	2	5	342	5	SDCCAG8	1	243437866	Missense_Mutation	DNP	AC	TCGA-CV-7424-01A-11D-2078-08	5773827	243437866	5812755	15	47045											
NLRP3	114548	broad.mit.edu	37	chr1	247588430	247588430	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgagacgtgacagtccttcTggaaaactatggcaaattcg	12	9	10	10	3	1	2	0	1	1	1	3	4	2	3	2	2	1	1	2	2	4	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:247588430T>G	uc001icr.2	+	5	1823	c.1685T>G	c.(1684-1686)CTG>CGG	p.L562R	NLRP3_uc001ics.2_Missense_Mutation_p.L562R|NLRP3_uc001icu.2_Missense_Mutation_p.L562R|NLRP3_uc001icw.2_Missense_Mutation_p.L562R|NLRP3_uc001icv.2_Missense_Mutation_p.L562R|NLRP3_uc010pyw.1_Missense_Mutation_p.L560R|NLRP3_uc001ict.1_Missense_Mutation_p.L560R	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	562					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ACAGTCCTTCTGGAAAACTAT	0.478													6	25					0	0	0	0	G	247588430	G	G	247588430	3	3	259	1	0	0	0	0	1	0	0	0	10532	1580	55	5	1695	5	NLRP3	1	247588430	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	4150564	247588430	1662191	16	47046											
OR2T4	127074	broad.mit.edu	37	chr1	248525602	248525602	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtgtcctcatgctcctCatccctgtggtgatcatttc	4	16	8	13	0	3	1	3	1	0	0	7	1	6	1	3	1	2	2	3	1	0	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr1:248525602C>A	uc001ieh.1	+	1	720	c.720C>A	c.(718-720)CTC>CTA	p.L240L		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	240	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCATGCTCCTCATCCCTGTGG	0.478													27	83					8.58068e-18	9.68664e-18	1	0	A	248525602	A	A	248525602	2	1	259	1	0	0	0	0	0	0	0	1	11081	813	29	2		2	OR2T4	1	248525602	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	937172	248525602	725019	17	47047											
MYT1L	23040	broad.mit.edu	37	chr2	1805525	1805525	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaattggattcatttagctcCttgatttcttcatctaactg	9	18	6	8	0	4	1	2	1	2	0	5	3	5	2	1	1	2	1	1	1	3	8			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:1805525C>T	uc002qxe.2	-	23	4046	c.3219G>A	c.(3217-3219)AAG>AAA	p.K1073K	MYT1L_uc002qxd.2_Silent_p.K1071K|MYT1L_uc010ewk.2_Silent_p.K69K	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1073	Potential.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CATTTAGCTCCTTGATTTCTT	0.323													17	75					0	0	0	0	T	1805525	T	T	1805525	2	4	259	1	0	0	0	0	0	0	0	1	10160	680	24	4		4	MYT1L	2	1805525	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08		1805525	241393848	18	47048											
APOB	338	broad.mit.edu	37	chr2	21224689	21224689	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctttttcagtaactccgtGatgtatatcagaaatgtgtg	11	15	9	6	1	2	2	2	1	0	1	3	2	3	2	1	0	2	3	1	0	4	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:21224689G>T	uc002red.2	-	29	13733	c.13605C>A	c.(13603-13605)ATC>ATA	p.I4535I		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4535					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTAACTCCGTGATGTATATCA	0.358													46	69					5.20006e-24	5.94962e-24	1	0	T	21224689	T	T	21224689	2	4	259	1	0	0	0	0	0	0	0	1	785	1280	45	2		2	APOB	2	21224689	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	19419164	21224689	221974684	19	47049											
CENPA	1058	broad.mit.edu	37	chr2	27016146	27016146	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttgaggagggactcggctGagctcctgcacccagtgttt	6	10	13	12	1	0	2	0	2	0	0	2	4	1	4	3	3	2	4	3	3	0	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:27016146G>A	uc002rhr.2	+	4	605	c.422G>A	c.(421-423)TGA>TAA	p.*141*	CENPA_uc002rht.2_RNA|CENPA_uc002rhs.2_Silent_p.*115*	NM_001809	NP_001800	P49450	CENPA_HUMAN	centromere protein A isoform a	141					CenH3-containing nucleosome assembly at centromere|establishment of mitotic spindle orientation|interspecies interaction between organisms|kinetochore assembly|mitotic prometaphase|protein localization to chromosome, centromeric region	condensed nuclear chromosome kinetochore|cytosol|nucleoplasm|nucleosome	chromatin binding|DNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGACTCGGCTGAGCTCCTGCA	0.557													55	98					0	0	0	0	A	27016146	A	A	27016146	2	1	259	1	0	0	0	0	0	0	0	1	3241	1285	45	2		2	CENPA	2	27016146	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	5791457	27016146	216183227	20	47050											
XDH	7498	broad.mit.edu	37	chr2	31572647	31572647	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtgaaaccctcaagcttCtggttgaagtgtgtcaggtc	10	11	12	8	0	3	2	2	2	1	0	4	2	3	2	1	3	2	2	1	3	4	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:31572647C>T	uc002rnv.1	-	26	2953	c.2874G>A	c.(2872-2874)CAG>CAA	p.Q958Q		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	958					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CCTCAAGCTTCTGGTTGAAGT	0.507													12	100					0	0	0	0	T	31572647	T	T	31572647	2	4	259	1	0	0	0	0	0	0	0	1	17494	912	32	2		2	XDH	2	31572647	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	4556501	31572647	211626726	21	47051											
ALMS1	7840	broad.mit.edu	37	chr2	73678290	73678290	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taggtagtcaaatacctgaaGaggctctcagagtttcttct	11	13	9	8	0	4	3	2	1	3	2	5	3	4	3	1	2	1	3	1	2	5	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:73678290G>C	uc002sje.1	+	10	4750	c.4639G>C	c.(4639-4641)GAG>CAG	p.E1547Q	ALMS1_uc002sjf.1_Missense_Mutation_p.E1503Q|ALMS1_uc002sjg.2_Missense_Mutation_p.E933Q|ALMS1_uc002sjh.1_Missense_Mutation_p.E933Q	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1545	22.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						AATACCTGAAGAGGCTCTCAG	0.473													24	112					0	0	0	0	C	73678290	C	C	73678290	3	2	259	1	0	0	0	0	1	0	0	0	535	943	33	2	4663	2	ALMS1	2	73678290	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	42105643	73678290	169521083	22	47052											
DCTN1	1639	broad.mit.edu	37	chr2	74593384	74593384	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctaccttgctggggggcCgctctgcatcatactccccc	5	9	9	18	1	2	0	1	0	1	0	3	0	3	0	5	3	4	3	5	3	2	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:74593384C>G	uc002skx.2	-	23	3058	c.2747G>C	c.(2746-2748)CGG>CCG	p.R916P	SLC4A5_uc002skl.2_5'Flank|DCTN1_uc002skt.1_5'Flank|DCTN1_uc002skv.2_Missense_Mutation_p.R782P|DCTN1_uc002sku.2_Missense_Mutation_p.R782P|DCTN1_uc002skw.1_Missense_Mutation_p.R892P|DCTN1_uc010ffd.2_Missense_Mutation_p.R896P|DCTN1_uc002sky.2_Missense_Mutation_p.R879P	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	916					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						GCTGGGGGGCCGCTCTGCATC	0.562													30	91					0	0	0	0	G	74593384	G	G	74593384	3	3	259	1	0	0	0	0	1	0	0	0	4323	652	23	3	1129	3	DCTN1	2	74593384	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	915094	74593384	168605989	23	47053											
WDR54	84058	broad.mit.edu	37	chr2	74652067	74652067	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtctggcggtcagggccAgaattcacattattgacccg	8	11	12	10	2	3	2	2	1	1	1	3	2	3	2	2	3	0	0	2	3	2	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:74652067A>T	uc002slb.2	+	7	660	c.600A>T	c.(598-600)CCA>CCT	p.P200P		NM_032118	NP_115494	Q9H977	WDR54_HUMAN	WD repeat domain 54	200	WD 2.										0						GGTCAGGGCCAGAATTCACAT	0.522													29	103					0	0	0	0	T	74652067	T	T	74652067	2	4	259	1	0	0	0	0	0	0	0	1	17374	175	7	5		5	WDR54	2	74652067	Silent	SNP	A	TCGA-CV-7424-01A-11D-2078-08	58683	74652067	168547306	24	47054											
REG3A	5068	broad.mit.edu	37	chr2	79385808	79385808	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccaggattttggtgacaaaAacaaggcatagcagtgggag	14	8	13	6	0	0	1	0	1	0	0	1	3	1	3	1	4	2	2	1	4	4	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:79385808A>T	uc002sod.1	-	2	419	c.164T>A	c.(163-165)TTT>TAT	p.F55Y	REG3A_uc002soe.1_Missense_Mutation_p.F55Y|REG3A_uc002sof.1_Missense_Mutation_p.F55Y	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	55	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						TGGTGACAAAAACAAGGCATA	0.552													21	45					0	0	0	0	T	79385808	T	T	79385808	3	4	259	1	0	0	0	0	1	0	0	0	13277	14	1	5	379	5	REG3A	2	79385808	Missense_Mutation	SNP	A	TCGA-CV-7424-01A-11D-2078-08	4733741	79385808	163813565	25	47055											
PTCD3	55037	broad.mit.edu	37	chr2	86344259	86344259	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	accccaaatattttcagaagGacatagctgaacctcatata	16	10	5	10	0	2	2	2	1	0	1	2	3	2	3	3	1	2	1	3	1	7	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:86344259G>A	uc002sqw.2	+	6	457	c.391G>A	c.(391-393)GAC>AAC	p.D131N	PTCD3_uc010ytc.1_RNA	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	131						mitochondrion	protein binding			ovary(1)	1						TTTTCAGAAGGACATAGCTGA	0.313													14	28					0	0	0	0	A	86344259	A	A	86344259	3	1	259	1	0	0	0	0	1	0	0	0	12791	1174	41	2	413	2	PTCD3	2	86344259	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	6958451	86344259	156855114	26	47056											
SMYD1	150572	broad.mit.edu	37	chr2	88405860	88405860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctaggttgtgaaattatgccGggagtgcctggagaagcagg	10	9	16	6	1	0	2	0	1	0	1	0	4	0	3	2	4	3	2	2	4	4	3	rs114851602	byFrequency	TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:88405860G>A	uc002ssr.2	+	8	1000	c.998G>A	c.(997-999)CGG>CAG	p.R333Q	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Missense_Mutation_p.R29Q	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	333					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						AAATTATGCCGGGAGTGCCTG	0.522													8	41					0	0	0	0	A	88405860	A	A	88405860	3	1	259	1	0	0	0	0	1	0	0	0	14885	1116	39	1	1028	1	SMYD1	2	88405860	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	2061601	88405860	154793513	27	47057											
TRIM43	129868	broad.mit.edu	37	chr2	96260835	96260835	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatgaggattttatggaaaaAgattcaagaaaatcagagaa	21	9	9	2	0	2	4	2	1	0	3	2	7	2	6	0	2	0	0	0	2	8	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:96260835A>G	uc002suv.2	+	3	585	c.449A>G	c.(448-450)AAG>AGG	p.K150R		NM_138800	NP_620155	Q96BQ3	TRI43_HUMAN	tripartite motif-containing 43	150	Potential.					intracellular	zinc ion binding			ovary(1)	1						TTATGGAAAAAGATTCAAGAA	0.403													28	36					0	0	0	0	G	96260835	G	G	96260835	3	3	259	1	0	0	0	0	1	0	0	0	16585	72	3	5	455	5	TRIM43	2	96260835	Missense_Mutation	SNP	A	TCGA-CV-7424-01A-11D-2078-08	7854975	96260835	146938538	28	47058											
RANBP2	5903	broad.mit.edu	37	chr2	109392196	109392196	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctctttgcagaaatctcaGacagaagaaataactagcac	16	9	6	10	0	2	4	1	0	2	4	4	4	3	4	1	0	3	2	1	0	5	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:109392196G>C	uc002tem.3	+	24	8427	c.8301G>C	c.(8299-8301)CAG>CAC	p.Q2767H		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2767					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AGAAATCTCAGACAGAAGAAA	0.323													14	83					0	0	0	0	C	109392196	C	C	109392196	3	2	259	1	0	0	0	0	1	0	0	0	13093	933	33	2	8395	2	RANBP2	2	109392196	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	13131361	109392196	133807177	29	47059											
CNTNAP5	129684	broad.mit.edu	37	chr2	125504962	125504962	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgacgctgacaaggatgaatGgtaatgagaatctccatctt	13	10	10	8	2	2	3	0	3	2	1	3	6	2	4	1	2	0	2	1	2	4	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:125504962G>T	uc002tno.2	+	14	2595	c.2231G>T	c.(2230-2232)TGG>TTG	p.W744L	CNTNAP5_uc010flu.2_Missense_Mutation_p.W745L	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	744	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AAGGATGAATGGTAATGAGAA	0.458													19	88					2.89027e-11	3.2058e-11	1	0	T	125504962	T	T	125504962	3	4	259	1	0	0	0	0	1	0	0	0	3665	1362	47	4	2285	4	CNTNAP5	2	125504962	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	16112766	125504962	117694411	30	47060											
LRP1B	53353	broad.mit.edu	37	chr2	141751681	141751681	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctccagctttacatatgtGaggtagtgcttctccaggat	8	14	9	10	0	2	1	0	1	2	0	4	2	2	2	2	2	3	3	2	2	3	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:141751681G>A	uc002tvj.1	-	16	3499	c.2527C>T	c.(2527-2529)CAC>TAC	p.H843Y	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	843	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTACATATGTGAGGTAGTGCT	0.408										TSP Lung(27;0.18)			12	38					0	0	0	0	A	141751681	A	A	141751681	3	1	259	1	0	0	0	0	1	0	0	0	9005	1290	45	2	11576	2	LRP1B	2	141751681	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	16246719	141751681	101447692	31	47061											
MAP1D	254042	broad.mit.edu	37	chr2	172926266	172926266	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaccactcaatcatatctaCttacacaagcagtcaagcag	15	9	4	13	0	5	0	4	0	1	0	5	0	5	0	1	0	4	2	1	0	6	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:172926266C>T	uc002uhk.2	+	2	154	c.81C>T	c.(79-81)TAC>TAT	p.Y27Y	MAP1D_uc010zdw.1_5'UTR	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	27					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			ATCATATCTACTTACACAAGC	0.363													9	133					0	0	0	0	T	172926266	T	T	172926266	2	4	259	1	0	0	0	0	0	0	0	1	9282	576	20	4		4	MAP1D	2	172926266	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	31174585	172926266	70273107	32	47062											
HOXD13	3239	broad.mit.edu	37	chr2	176958202	176958202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggaggtatccttctaccaggGctatacgagcccttaccagc	9	9	10	13	1	1	0	0	0	1	0	2	2	2	1	4	3	5	2	4	3	5	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:176958202G>A	uc002ukf.1	+	1	671	c.584G>A	c.(583-585)GGC>GAC	p.G195D		NM_000523	NP_000514	P35453	HXD13_HUMAN	homeobox D13	195					skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		TTCTACCAGGGCTATACGAGC	0.622			T	NUP98	AML*								14	66					0	0	0	0	A	176958202	A	A	176958202	3	1	259	1	0	0	0	0	1	0	0	0	7361	1203	42	4	586	4	HOXD13	2	176958202	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	4031936	176958202	66241171	33	47063											
NFE2L2	4780	broad.mit.edu	37	chr2	178098960	178098960	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctcgacttactccaagatCtatatcttgcctccaaagta	11	14	4	12	1	3	1	0	0	3	1	6	2	5	1	3	0	2	1	3	0	6	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:178098960C>G	uc002ulh.3	-	2	640	c.85G>C	c.(85-87)GAT>CAT	p.D29H	NFE2L2_uc002ulg.3_Missense_Mutation_p.D13H|NFE2L2_uc010zfa.1_Missense_Mutation_p.D13H|NFE2L2_uc002uli.3_Missense_Mutation_p.D13H|NFE2L2_uc010fra.2_Missense_Mutation_p.D13H|NFE2L2_uc010frb.2_Missense_Mutation_p.D13H	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	29					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ACTCCAAGATCTATATCTTGC	0.363			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			8	32					0	0	0	0	G	178098960	G	G	178098960	3	3	259	1	0	0	0	0	1	0	0	0	10422	913	32	2	1748	2	NFE2L2	2	178098960	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	1140758	178098960	65100413	34	47064											
ZNF804A	91752	broad.mit.edu	37	chr2	185801912	185801912	+	Frame_Shift_Del	DEL	A	-	-																															tccataaaagtagaagaaagAaaaaaagaaaaaagttatgt																										TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:185801912delA	uc002uph.2	+	4	2383	c.1789delA	c.(1789-1791)AAAfs	p.K597fs		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	597						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TAGAAGAAAGAAAAAAAGAAA	0.323													---	---	---								-	185801912	-	-	185801912	7	5	259	1	0	1	0	1	0	0	0	0	18237	247	9	0	1803	0	ZNF804A	2	185801912	Frame_Shift_Del	DEL	A	TCGA-CV-7424-01A-11D-2078-08	7702952	185801912	57397461	35	47065											
DNAH7	56171	broad.mit.edu	37	chr2	196866401	196866401	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaactgaaccatacttactgGgggttgtgcaattaagtccg	11	11	11	8	1	0	1	0	1	0	0	1	2	1	1	2	2	5	2	2	2	6	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:196866401G>A	uc002utj.3	-	11	1272	c.1171C>T	c.(1171-1173)CCA>TCA	p.P391S		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	391	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATACTTACTGGGGGTTGTGCA	0.368													15	41					0	0	0	0	A	196866401	A	A	196866401	3	1	259	1	0	0	0	0	1	0	0	0	4628	1232	43	4	11123	4	DNAH7	2	196866401	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	11064489	196866401	46332972	36	47066											
CLK1	1195	broad.mit.edu	37	chr2	201722606	201722606	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccaacatctggacacagcGgctacaaacacatgaaaaat	17	7	6	11	1	1	1	0	1	1	0	2	2	2	2	1	2	4	1	1	2	5	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:201722606G>A	uc002uwe.2	-	7	848	c.667C>T	c.(667-669)CGC>TGC	p.R223C	CLK1_uc002uwd.2_Missense_Mutation_p.R46C|CLK1_uc010zhi.1_Missense_Mutation_p.R265C|CLK1_uc002uwf.2_5'UTR|CLK1_uc002uwg.2_Missense_Mutation_p.R72C|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	223	Protein kinase.				cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						TGGACACAGCGGCTACAAACA	0.353													8	139					0	0	0	0	A	201722606	A	A	201722606	3	1	259	1	0	0	0	0	1	0	0	0	3551	1130	39	1	815	1	CLK1	2	201722606	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	4856205	201722606	41476767	37	47067											
KIAA1486	57624	broad.mit.edu	37	chr2	226447464	226447464	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcccccgtcagcatggggaGgtccctgactcccctgagcc	5	7	11	18	1	1	2	1	2	0	0	4	3	4	3	6	3	2	1	6	3	0	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:226447464G>T	uc002voe.2	+	4	1506	c.1331G>T	c.(1330-1332)AGG>ATG	p.R444M	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.R214M	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	444	Pro-rich.									ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		AGCATGGGGAGGTCCCTGACT	0.637													8	42					1.06961e-07	1.17104e-07	1	0	T	226447464	T	T	226447464	3	4	259	1	0	0	0	0	1	0	0	0	8276	1000	35	4	1341	4	KIAA1486	2	226447464	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	24724858	226447464	16751909	38	47068											
DIS3L2	129563	broad.mit.edu	37	chr2	233201320	233201320	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggagtctgacggtgagcccGaggactcaagcaccagctga	11	5	14	11	2	2	3	1	3	1	0	2	6	2	5	2	3	3	2	2	3	1	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:233201320G>A	uc010fxz.2	+	21	2914	c.2638G>A	c.(2638-2640)GAG>AAG	p.E880K	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA|DIS3L2_uc002vsp.1_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	880							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CGGTGAGCCCGAGGACTCAAG	0.557													3	7					0	0	0	0	A	233201320	A	A	233201320	3	1	259	1	0	0	0	0	1	0	0	0	4559	1059	37	1	2716	1	DIS3L2	2	233201320	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	6753856	233201320	9998053	39	47069											
ING5	84289	broad.mit.edu	37	chr2	242650891	242650891	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttgaaagctccggagggCgagggttaaaaagcaagtct	13	9	13	6	2	1	1	0	1	1	0	2	3	2	2	1	3	2	3	1	3	5	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr2:242650891C>T	uc002wcd.2	+	4	401	c.376C>T	c.(376-378)CGA>TGA	p.R126*	ING5_uc002wcc.1_Nonsense_Mutation_p.R126*	NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	126					DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		CTCCGGAGGGCGAGGGTTAAA	0.398													17	46					0	0	0	0	T	242650891	T	T	242650891	4	4	259	1	0	0	0	0	0	1	0	0	7778	760	27	1	390	1	ING5	2	242650891	Nonsense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	9449571	242650891	548482	40	47070											
TTLL3	26140	broad.mit.edu	37	chr3	9859377	9859377	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgccgtggtttgatgaggttGatgccaactccttcttccca	6	14	10	11	1	1	3	0	3	1	0	3	3	3	3	4	2	3	2	4	2	1	4	rs73116112	by1000genomes	TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:9859377G>C	uc003btg.2	+	5	580	c.364G>C	c.(364-366)GAT>CAT	p.D122H	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_Missense_Mutation_p.D122H|TTLL3_uc003btf.3_5'UTR|TTLL3_uc010hco.1_Missense_Mutation_p.D58H|TTLL3_uc003bth.3_5'UTR|TTLL3_uc011atj.1_Missense_Mutation_p.D58H|TTLL3_uc003btj.3_5'UTR|TTLL3_uc003bti.3_5'UTR	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	122					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					TGATGAGGTTGATGCCAACTC	0.552													6	117					0	0	0	0	C	9859377	C	C	9859377	3	2	259	1	0	0	0	0	1	0	0	0	16796	1290	45	2	378	2	TTLL3	3	9859377	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		9859377	188163053	41	47071											
EPHA6	285220	broad.mit.edu	37	chr3	96706569	96706569	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggattttatctggctttTcaagacattggggcgtgcat	10	14	11	6	1	2	1	1	0	1	1	2	2	2	2	0	4	1	2	0	4	3	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:96706569T>A	uc010how.1	+	3	889	c.846T>A	c.(844-846)TTT>TTA	p.F282L	EPHA6_uc003drp.1_Missense_Mutation_p.F282L	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	187	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						ATCTGGCTTTTCAAGACATTG	0.453													32	324					0	0	0	0	A	96706569	A	A	96706569	3	1	259	1	0	0	0	0	1	0	0	0	5195	1780	62	5	856	5	EPHA6	3	96706569	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	86847192	96706569	101315861	42	47072											
NPHP3	27031	broad.mit.edu	37	chr3	132435688	132435688	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactgctgaagctggatcaTgcttcctatggaaggttcac	9	11	12	9	0	2	1	2	1	0	0	3	4	3	4	1	4	3	4	1	4	3	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:132435688T>C	uc003epe.1	-	4	813	c.736A>G	c.(736-738)ATG>GTG	p.M246V	NPHP3_uc003epf.1_Missense_Mutation_p.M1V	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	246					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						AGCTGGATCATGCTTCCTATG	0.458													27	101					0	0	0	0	C	132435688	C	C	132435688	3	2	259	1	0	0	0	0	1	0	0	0	10634	1464	51	5	3352	5	NPHP3	3	132435688	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	35729119	132435688	65586742	43	47073											
SLC9A9	285195	broad.mit.edu	37	chr3	143082405	143082405	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttatccaagttatttgcttCctggggagaaacaatagaaa	14	13	8	6	0	0	2	0	0	0	2	2	3	2	2	2	2	2	2	2	2	7	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:143082405C>A	uc003evn.2	-	14	1707	c.1525G>T	c.(1525-1527)GAA>TAA	p.E509*		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	509					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						TTATTTGCTTCCTGGGGAGAA	0.318													7	86					5.18039e-06	5.59923e-06	1	0	A	143082405	A	A	143082405	4	1	259	1	0	0	0	0	0	1	0	0	14785	869	30	2	424	2	SLC9A9	3	143082405	Nonsense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	10646717	143082405	54940025	44	47074											
PLOD2	5352	broad.mit.edu	37	chr3	145809656	145809656	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttatcctgtgtccatgaattGggtacatagtttccaaaata	12	15	7	7	0	0	1	0	1	0	0	3	1	3	1	3	1	1	2	3	1	7	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:145809656G>T	uc003evs.1	-	8	1316	c.810C>A	c.(808-810)CCC>CCA	p.P270P	PLOD2_uc011bnm.1_Silent_p.P215P|PLOD2_uc003evr.1_Silent_p.P270P	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	270					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	TCCATGAATTGGGTACATAGT	0.373													6	69					0.00116845	0.00121633	1	0	T	145809656	T	T	145809656	2	4	259	1	0	0	0	0	0	0	0	1	12157	1335	47	4		4	PLOD2	3	145809656	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	2727251	145809656	52212774	45	47075											
OTOL1	131149	broad.mit.edu	37	chr3	161221227	161221227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgggacctactgggccgaagGgtgacattggcaacaaaggg	11	6	16	8	1	0	1	0	1	0	0	0	3	0	2	2	5	2	1	2	5	4	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:161221227G>A	uc011bpb.1	+	4	931	c.931G>A	c.(931-933)GGT>AGT	p.G311S		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	311	Collagen-like 3.					collagen					0						TGGGCCGAAGGGTGACATTGG	0.597													17	19					0	0	0	0	A	161221227	A	A	161221227	3	1	259	1	0	0	0	0	1	0	0	0	11358	1232	43	4	945	4	OTOL1	3	161221227	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	15411571	161221227	36801203	46	47076											
SI	6476	broad.mit.edu	37	chr3	164773033	164773033	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaaaatactgcattcattTgcccaccaatcaatgcagtt	13	12	6	10	0	2	0	2	0	0	0	2	1	2	1	2	1	4	3	2	1	5	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:164773033T>G	uc003fei.2	-	13	1523	c.1461A>C	c.(1459-1461)GCA>GCC	p.A487A		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	487	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGCATTCATTTGCCCACCAAT	0.343										HNSCC(35;0.089)			60	65					0	0	0	0	G	164773033	G	G	164773033	2	3	259	1	0	0	0	0	0	0	0	1	14362	1799	63	5		5	SI	3	164773033	Silent	SNP	T	TCGA-CV-7424-01A-11D-2078-08	3551806	164773033	33249397	47	47077											
SI	6476	broad.mit.edu	37	chr3	164783161	164783161	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatataatcacttggaagaCgggttgagatctgtaagtac	15	11	10	5	1	2	2	1	1	1	2	2	4	2	3	0	2	1	3	0	2	6	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:164783161C>T	uc003fei.2	-	7	757	c.695G>A	c.(694-696)CGT>CAT	p.R232H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	232	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACTTGGAAGACGGGTTGAGAT	0.353										HNSCC(35;0.089)			8	55					0	0	0	0	T	164783161	T	T	164783161	3	4	259	1	0	0	0	0	1	0	0	0	14362	536	19	1	4956	1	SI	3	164783161	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	10128	164783161	33239269	48	47078											
SKIL	6498	broad.mit.edu	37	chr3	170099035	170099035	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccatgtttttctgcagacaGatgcaccatcaggaatggaa	12	11	9	9	0	2	2	1	0	1	2	3	4	3	4	2	2	2	3	2	2	2	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:170099035G>C	uc003fgu.2	+	3	1814	c.1102G>C	c.(1102-1104)GAT>CAT	p.D368H	SKIL_uc011bps.1_Missense_Mutation_p.D348H|SKIL_uc003fgv.2_Missense_Mutation_p.D368H|SKIL_uc003fgw.2_Missense_Mutation_p.D368H	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	368					cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TCTGCAGACAGATGCACCATC	0.289													9	145					0	0	0	0	C	170099035	C	C	170099035	3	2	259	1	0	0	0	0	1	0	0	0	14423	942	33	2	1108	2	SKIL	3	170099035	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	5315874	170099035	27923395	49	47079											
PIK3CA	5290	broad.mit.edu	37	chr3	178916836	178916836	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acattttcgtaagtgttactCaagaagcagaaagggaagaa	17	9	10	5	1	1	3	1	0	0	3	2	4	1	4	0	1	2	3	0	1	7	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:178916836C>G	uc003fjk.2	+	2	380	c.223C>G	c.(223-225)CAA>GAA	p.Q75E		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	75	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.Q75E(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AAGTGTTACTCAAGAAGCAGA	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			49	134					0	0	0	0	G	178916836	G	G	178916836	3	3	259	1	0	0	0	0	1	0	0	0	11968	827	29	2	225	2	PIK3CA	3	178916836	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	8817801	178916836	19105594	50	47080											
EPHB3	2049	broad.mit.edu	37	chr3	184295735	184295735	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcccctcatcgtgggctcCgctacagctgggcttgtctt	3	13	10	15	2	2	0	1	0	1	0	5	0	4	0	3	2	2	4	3	2	1	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:184295735C>T	uc003foz.2	+	8	2126	c.1689C>T	c.(1687-1689)TCC>TCT	p.S563S		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	563	Helical; (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TCGTGGGCTCCGCTACAGCTG	0.642													12	93					0	0	0	0	T	184295735	T	T	184295735	2	4	259	1	0	0	0	0	0	0	0	1	5200	639	23	1		1	EPHB3	3	184295735	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	5378899	184295735	13726695	51	47081											
ETV5	2119	broad.mit.edu	37	chr3	185774946	185774946	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggctgggtcatcaagaaggGtgaccaggaactgccacagc	11	6	14	10	0	2	2	2	1	0	1	2	3	2	3	2	4	3	1	2	4	3	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr3:185774946G>A	uc003fpz.2	-	11	1374	c.1127C>T	c.(1126-1128)ACC>ATC	p.T376I	ETV5_uc003fpy.2_Missense_Mutation_p.T418I	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	376	ETS.				cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			ATCAAGAAGGGTGACCAGGAA	0.552			T	TMPRSS2|SCL45A3	Prostate 								22	73					0	0	0	0	A	185774946	A	A	185774946	3	1	259	1	0	0	0	0	1	0	0	0	5306	1261	44	4	417	4	ETV5	3	185774946	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	1479211	185774946	12247484	52	47082											
CTBP1	1487	broad.mit.edu	37	chr4	1222118	1222119	+	Missense_Mutation	DNP	GC	AA	AA																															ggtacatcagggcccccacaGcctcgttcaggacctgcagc																										TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr4:1222118_1222119GC>AA	uc003gcv.1	-	3	373_374	c.208_209GC>TT	c.(208-210)GCT>TTT	p.A70F	CTBP1_uc003gct.1_Missense_Mutation_p.A51F|CTBP1_uc003gcu.1_Missense_Mutation_p.A59F	NM_001328	NP_001319	Q13363	CTBP1_HUMAN	C-terminal binding protein 1 isoform 1	70	Interaction with GLIS2 1 (By similarity).				interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		GGCCCCCACAGCCTCGTTCAGG	0.619													7	54					0	0	0	0	AA	1222119	AA	AA	1222118	3	1	259	1	0	0	0	0	1	0	0	0	4014	971	34	4	1141	4	CTBP1	4	1222118	Missense_Mutation	DNP	GC	TCGA-CV-7424-01A-11D-2078-08		1222118	189932158	53	47083											
ADD1	118	broad.mit.edu	37	chr4	2883674	2883674	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acaggagcaatttaagaaggGgaagaaccccacaggcctat	16	5	11	9	0	0	2	0	0	0	2	0	4	0	4	3	4	2	1	3	4	6	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr4:2883674G>A	uc003gfr.2	+	3	433	c.245G>A	c.(244-246)GGG>GAG	p.G82E	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Missense_Mutation_p.G82E|ADD1_uc003gfo.2_Missense_Mutation_p.G82E|ADD1_uc003gfp.2_Missense_Mutation_p.G82E|ADD1_uc003gfq.2_Missense_Mutation_p.G82E|ADD1_uc003gfs.2_Missense_Mutation_p.G82E|ADD1_uc003gft.3_Missense_Mutation_p.G82E	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	82					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTTAAGAAGGGGAAGAACCCC	0.408													10	74					0	0	0	0	A	2883674	A	A	2883674	3	1	259	1	0	0	0	0	1	0	0	0	304	1232	43	4	251	4	ADD1	4	2883674	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	1661556	2883674	188270602	54	47084											
NKX3-2	579	broad.mit.edu	37	chr4	13545814	13545814	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccgcagctgttctggtaccGgcaggagacgccagcagaga	9	5	14	13	3	1	2	0	0	1	2	1	4	1	2	3	3	3	6	3	3	1	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr4:13545814G>A	uc003gmx.2	-	1	301	c.225C>T	c.(223-225)GCC>GCT	p.A75A		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	75					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTCTGGTACCGGCAGGAGACG	0.662													5	5					0	0	0	0	A	13545814	A	A	13545814	2	1	259	1	0	0	0	0	0	0	0	1	10510	1103	39	1		1	NKX3-2	4	13545814	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	10662140	13545814	177608462	55	47085											
HSD17B13	345275	broad.mit.edu	37	chr4	88243866	88243866	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgcctattccatgcccagctCcagtaatgagaacaatctcc	11	10	6	14	0	1	1	0	1	1	1	4	2	3	1	5	0	4	2	5	0	4	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr4:88243866C>G	uc003hqo.2	-	1	191	c.128G>C	c.(127-129)GGA>GCA	p.G43A	HSD17B13_uc010ikk.2_Missense_Mutation_p.G43A	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	43	NAD (By similarity).					extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		ATGCCCAGCTCCAGTAATGAG	0.423													9	98					0	0	0	0	G	88243866	G	G	88243866	3	3	259	1	0	0	0	0	1	0	0	0	7421	855	30	2	802	2	HSD17B13	4	88243866	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	74698052	88243866	102910410	56	47086											
BANK1	55024	broad.mit.edu	37	chr4	102984276	102984276	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcattattgggaaaaggccAgaagaagaaaatgtctatag	17	9	11	4	0	1	3	0	0	1	3	1	4	1	4	1	2	1	1	1	2	9	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr4:102984276A>G	uc003hvy.3	+	13	2467	c.2193A>G	c.(2191-2193)CCA>CCG	p.P731P	BANK1_uc003hvx.3_Silent_p.P716P|BANK1_uc010ill.2_Silent_p.P598P|BANK1_uc003hvz.3_Silent_p.P701P	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	731					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		GGAAAAGGCCAGAAGAAGAAA	0.254													6	34					0	0	0	0	G	102984276	G	G	102984276	2	3	259	1	0	0	0	0	0	0	0	1	1311	175	7	5		5	BANK1	4	102984276	Silent	SNP	A	TCGA-CV-7424-01A-11D-2078-08	14740410	102984276	88170000	57	47087											
GSTCD	79807	broad.mit.edu	37	chr4	106638773	106638773	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccaatgaaagaagaaaatGaaagccataaagaaaagtct	23	5	7	6	0	1	5	0	2	1	3	1	5	1	5	2	0	1	0	2	0	10	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr4:106638773G>A	uc003hxz.3	+	2	75	c.3G>A	c.(1-3)ATG>ATA	p.M1I	GSTCD_uc003hxx.2_Missense_Mutation_p.M1I|GSTCD_uc003hxy.3_Missense_Mutation_p.M1I|GSTCD_uc011cfb.1_Intron|GSTCD_uc010ils.1_Missense_Mutation_p.M1I	NM_001031720	NP_001026890	Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain	1						cytoplasm	rRNA methyltransferase activity			breast(1)|central_nervous_system(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)		AGAAGAAAATGAAAGCCATAA	0.313													7	34					0	0	0	0	A	106638773	A	A	106638773	3	1	259	1	0	0	0	0	1	0	0	0	6874	1290	45	2	5	2	GSTCD	4	106638773	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	3654497	106638773	84515503	58	47088											
SCLT1	132320	broad.mit.edu	37	chr4	129886441	129886441	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacgcctatctgatgcttcCtctcttccatgggcagacac	9	11	7	14	1	2	2	0	1	2	1	5	2	4	2	3	1	2	2	3	1	2	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr4:129886441C>T	uc003igp.2	-	11	1316	c.810G>A	c.(808-810)GAG>GAA	p.E270E	SCLT1_uc003ign.2_Intron|SCLT1_uc003igo.2_5'UTR|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	270	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						CTGATGCTTCCTCTCTTCCAT	0.343													9	29					0	0	0	0	T	129886441	T	T	129886441	2	4	259	1	0	0	0	0	0	0	0	1	13971	680	24	4		4	SCLT1	4	129886441	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	23247668	129886441	61267835	59	47089											
SH3RF1	57630	broad.mit.edu	37	chr4	170028206	170028206	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccctgccatggccacctcCtggtggcagttcgggcccca	4	8	12	17	1	0	0	0	0	0	0	2	0	1	0	7	4	2	2	7	4	0	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr4:170028206C>T	uc003isa.1	-	11	2625	c.2290G>A	c.(2290-2292)GGA>AGA	p.G764R		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	764						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TGGCCACCTCCTGGTGGCAGT	0.672													9	21					0	0	0	0	T	170028206	T	T	170028206	3	4	259	1	0	0	0	0	1	0	0	0	14323	690	24	4	384	4	SH3RF1	4	170028206	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	40141765	170028206	21126070	60	47090											
KIAA0947	23379	broad.mit.edu	37	chr5	5461296	5461296	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaagatgatgactcaggtGatggaatggatgtagcaggg	13	8	16	4	0	1	5	1	3	0	2	1	7	1	7	0	4	1	2	0	4	3	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:5461296G>A	uc003jdm.3	+	13	2071	c.1849G>A	c.(1849-1851)GAT>AAT	p.D617N		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	617										ovary(1)|central_nervous_system(1)	2						TGACTCAGGTGATGGAATGGA	0.418													25	49					0	0	0	0	A	5461296	A	A	5461296	3	1	259	1	0	0	0	0	1	0	0	0	8241	1290	45	2	1899	2	KIAA0947	5	5461296	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		5461296	175453964	61	47091											
PAPD7	11044	broad.mit.edu	37	chr5	6749698	6749698	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagaatcatcaaagtaactCaggaggtgattgactaccgg	15	8	11	7	1	3	3	3	2	0	1	3	5	3	4	1	3	2	1	1	3	5	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:6749698C>T	uc003jdx.1	+	9	994	c.865C>T	c.(865-867)CAG>TAG	p.Q289*	PAPD7_uc011cmn.1_Nonsense_Mutation_p.Q280*|PAPD7_uc010itl.1_Nonsense_Mutation_p.Q109*	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	289					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						CAAAGTAACTCAGGAGGTGAT	0.488													20	138					0	0	0	0	T	6749698	T	T	6749698	4	4	259	1	0	0	0	0	0	1	0	0	11480	827	29	2	895	2	PAPD7	5	6749698	Nonsense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	1288402	6749698	174165562	62	47092											
DNAH5	1767	broad.mit.edu	37	chr5	13737360	13737360	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtctttcattaccaaactcaCcaggtctgtattcctcccgg	8	13	6	14	1	4	0	2	0	2	0	6	0	6	0	4	2	2	1	4	2	3	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:13737360C>A	uc003jfd.2	-	66	11497	c.11455_splice	c.e66+1	p.V3819_splice	DNAH5_uc003jfc.2_Intron	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACCAAACTCACCAGGTCTGTA	0.403									Kartagener_syndrome				31	83					2.20262e-25	2.53152e-25	1	0	A	13737360	A	A	13737360	5	1	259	1	0	0	0	0	0	0	1	0	4626	521	18	4	2474	4	DNAH5	5	13737360	Splice_Site	SNP	C	TCGA-CV-7424-01A-11D-2078-08	6987662	13737360	167177900	63	47093											
DNAH5	1767	broad.mit.edu	37	chr5	13850873	13850873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actgggcacttcatgtgcccGagtcatgatcttcacccaag	9	10	9	13	1	4	1	3	1	1	0	4	2	4	1	2	1	1	1	2	1	1	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:13850873G>A	uc003jfd.2	-	31	5044	c.5002C>T	c.(5002-5004)CGG>TGG	p.R1668W		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1668	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCATGTGCCCGAGTCATGATC	0.468									Kartagener_syndrome				17	79					0	0	0	0	A	13850873	A	A	13850873	3	1	259	1	0	0	0	0	1	0	0	0	4626	1057	37	1	9068	1	DNAH5	5	13850873	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	113513	13850873	167064387	64	47094											
PRDM9	56979	broad.mit.edu	37	chr5	23526576	23526577	+	Nonsense_Mutation	DNP	CC	AA	AA																															tcaagagatcaaagaaaggtCcaaactcttgaataaaagga																										TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:23526576_23526577CC>AA	uc003jgo.2	+	11	1561_1562	c.1379_1380CC>AA	c.(1378-1380)TCC>TAA	p.S460*		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	460					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AAAGAAAGGTCCAAACTCTTGA	0.465										HNSCC(3;0.000094)			4	21					0	0	0	0	AA	23526577	AA	AA	23526576	4	1	259	1	0	0	0	0	0	1	0	0	12525	855	30	2	1417	2	PRDM9	5	23526576	Nonsense_Mutation	DNP	CC	TCGA-CV-7424-01A-11D-2078-08	9675703	23526576	157388684	65	47095											
TTC23L	153657	broad.mit.edu	37	chr5	34863073	34863073	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgacctggaaggcaaatacGacctcaaataaggagaaaga	18	6	10	7	1	1	3	1	1	0	2	1	6	1	4	2	3	1	1	2	3	6	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:34863073G>A	uc003jiu.2	+	5	553	c.450G>A	c.(448-450)ACG>ACA	p.T150T	TTC23L_uc003jiv.2_5'Flank|TTC23L_uc010iut.1_5'Flank	NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	150							binding			central_nervous_system(1)	1						AGGCAAATACGACCTCAAATA	0.512													14	38					0	0	0	0	A	34863073	A	A	34863073	2	1	259	1	0	0	0	0	0	0	0	1	16759	1045	37	1		1	TTC23L	5	34863073	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	11336497	34863073	146052187	66	47096											
PRLR	5618	broad.mit.edu	37	chr5	35070259	35070259	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgaaggtcgctggactccAtgcactccagtatccatggt	10	10	10	11	1	0	1	0	1	0	0	4	2	3	2	3	3	1	3	3	3	3	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:35070259A>C	uc003jjm.2	-	7	1182	c.652T>G	c.(652-654)TGG>GGG	p.W218G	PRLR_uc003jjg.1_Missense_Mutation_p.W218G|PRLR_uc003jjh.1_Missense_Mutation_p.W218G|PRLR_uc003jji.1_Missense_Mutation_p.W147G|PRLR_uc003jjj.1_Missense_Mutation_p.W218G|PRLR_uc003jjk.1_Missense_Mutation_p.W147G|PRLR_uc003jjl.3_Missense_Mutation_p.W117G|PRLR_uc010iuw.1_Missense_Mutation_p.W147G	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	218	Fibronectin type-III 2.|WSXWS motif.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GCTGGACTCCATGCACTCCAG	0.433													12	25					0	0	0	0	C	35070259	C	C	35070259	3	2	259	1	0	0	0	0	1	0	0	0	12593	217	8	5	1232	5	PRLR	5	35070259	Missense_Mutation	SNP	A	TCGA-CV-7424-01A-11D-2078-08	207186	35070259	145845001	67	47097											
C5orf42	65250	broad.mit.edu	37	chr5	37157808	37157808	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgtgggggaacagcattagTaactgaagctgccatataat	14	10	11	6	0	0	1	0	1	0	0	0	2	0	2	1	2	5	3	1	2	6	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:37157808T>C	uc011cpa.1	-	40	8152	c.7921A>G	c.(7921-7923)ACT>GCT	p.T2641A	C5orf42_uc003jkp.1_RNA|C5orf42_uc011coy.1_Missense_Mutation_p.T1159A|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.T1734A	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2641										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ACAGCATTAGTAACTGAAGCT	0.328													25	41					0	0	0	0	C	37157808	C	C	37157808	3	2	259	1	0	0	0	0	1	0	0	0	2311	1638	57	5	1724	5	C5orf42	5	37157808	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	2087549	37157808	143757452	68	47098											
WDR70	55100	broad.mit.edu	37	chr5	37379491	37379491	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggagcgctctgggcccagcGaaggtgggtttcatgaggcg	6	8	18	9	3	2	1	1	1	1	0	2	3	2	2	1	5	2	2	1	5	1	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:37379491G>A	uc003jkv.2	+	1	80	c.22G>A	c.(22-24)GAA>AAA	p.E8K	WDR70_uc010iva.1_Missense_Mutation_p.E8K	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	8										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGGGCCCAGCGAAGGTGGGTT	0.642													49	123					0	0	0	0	A	37379491	A	A	37379491	3	1	259	1	0	0	0	0	1	0	0	0	17389	1059	37	1	24	1	WDR70	5	37379491	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	221683	37379491	143535769	69	47099											
CARD6	84674	broad.mit.edu	37	chr5	40854255	40854255	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcccatgtgcaagagctctCagttcaaatccgatcagtcc	11	10	7	13	1	3	1	3	0	1	1	7	2	6	1	3	0	2	3	3	0	2	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:40854255C>G	uc003jmg.2	+	3	2896	c.2821C>G	c.(2821-2823)CAG>GAG	p.Q941E		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	941					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						CAAGAGCTCTCAGTTCAAATC	0.493													23	145					0	0	0	0	G	40854255	G	G	40854255	3	3	259	1	0	0	0	0	1	0	0	0	2662	827	29	2	2831	2	CARD6	5	40854255	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	3474764	40854255	140061005	70	47100											
VCAN	1462	broad.mit.edu	37	chr5	82832967	82832967	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgacataattgaaatagAcctataccacagtgaagaaa	18	8	6	9	0	0	5	0	3	0	2	0	5	0	5	3	0	1	0	3	0	7	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:82832967A>T	uc003kii.3	+	8	4501	c.4145A>T	c.(4144-4146)GAC>GTC	p.D1382V	VCAN_uc003kij.3_Missense_Mutation_p.D395V|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.D46V	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1382	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ATTGAAATAGACCTATACCAC	0.343													7	25					0	0	0	0	T	82832967	T	T	82832967	3	4	259	1	0	0	0	0	1	0	0	0	17206	275	10	5	4171	5	VCAN	5	82832967	Missense_Mutation	SNP	A	TCGA-CV-7424-01A-11D-2078-08	41978712	82832967	98082293	71	47101											
GPR98	84059	broad.mit.edu	37	chr5	89924449	89924449	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgaattgggtgttgacaCggaacagcactgatccctca	10	9	11	11	2	1	2	1	2	0	0	2	4	2	3	1	2	3	2	1	2	2	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:89924449C>G	uc003kju.2	+	8	1405	c.1309C>G	c.(1309-1311)CGG>GGG	p.R437G	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	437	Extracellular (Potential).			LTR -> VTP (in Ref. 2; AAL30811).	cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGTGTTGACACGGAACAGCAC	0.423													22	24					0	0	0	0	G	89924449	G	G	89924449	3	3	259	1	0	0	0	0	1	0	0	0	6760	527	19	3	1339	3	GPR98	5	89924449	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	7091482	89924449	90990811	72	47102											
PCDHA11	56138	broad.mit.edu	37	chr5	140250371	140250371	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggacgagaacgacaacgcGccggcactgctggcgactca	10	4	13	14	6	1	1	1	0	0	1	1	5	1	2	1	3	3	2	1	3	2	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:140250371G>A	uc003lia.2	+	1	2541	c.1683G>A	c.(1681-1683)GCG>GCA	p.A561A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.A561A	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	561	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGACAACGCGCCGGCACTGC	0.682													21	95					0	0	0	0	A	140250371	A	A	140250371	2	1	259	1	0	0	0	0	0	0	0	1	11575	1074	38	1		1	PCDHA11	5	140250371	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	50325922	140250371	40664889	73	47103											
PCDHB12	56124	broad.mit.edu	37	chr5	140590194	140590194	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagaacggctccgcgccctGcaccgagctggtgccctggg	5	5	15	16	4	0	1	0	0	0	1	1	2	1	1	4	3	4	4	4	3	1	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:140590194G>T	uc003liz.2	+	1	1904	c.1715G>T	c.(1714-1716)TGC>TTC	p.C572F	PCDHB12_uc011dak.1_Missense_Mutation_p.C235F	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	572	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCGCGCCCTGCACCGAGCTG	0.701													32	46					1.69901e-12	1.89276e-12	1	0	T	140590194	T	T	140590194	3	4	259	1	0	0	0	0	1	0	0	0	11591	1319	46	4	1717	4	PCDHB12	5	140590194	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	339823	140590194	40325066	74	47104											
CLINT1	9685	broad.mit.edu	37	chr5	157240172	157240172	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaagcctgtcgtcatcctggGcaaattcaaccaattccttc	10	11	7	13	1	2	0	2	0	0	0	6	1	4	0	4	1	2	1	4	1	4	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr5:157240172G>A	uc003lxj.1	-	5	606	c.416C>T	c.(415-417)GCC>GTC	p.A139V	CLINT1_uc003lxi.1_Missense_Mutation_p.A121V|CLINT1_uc011ddv.1_Missense_Mutation_p.A139V	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	139	ENTH.				endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTCATCCTGGGCAAATTCAAC	0.413													13	45					0	0	0	0	A	157240172	A	A	157240172	3	1	259	1	0	0	0	0	1	0	0	0	3546	1203	42	4	1493	4	CLINT1	5	157240172	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	16649978	157240172	23675088	75	47105											
HIVEP1	3096	broad.mit.edu	37	chr6	12122522	12122522	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgtctgtaccttcacttGactgtttacctatcacaaga	9	16	5	11	0	4	2	2	1	2	1	4	2	4	2	2	0	2	2	2	0	4	7			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr6:12122522G>A	uc003nac.2	+	4	2673	c.2494G>A	c.(2494-2496)GAC>AAC	p.D832N	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	832					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				ACCTTCACTTGACTGTTTACC	0.428													7	127					0	0	0	0	A	12122522	A	A	12122522	3	1	259	1	0	0	0	0	1	0	0	0	7225	1290	45	2	2504	2	HIVEP1	6	12122522	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		12122522	158992545	76	47106											
OR2W1	26692	broad.mit.edu	37	chr6	29012395	29012395	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtgtctacacaagctatCttgaccagagctggcaactc	10	10	10	11	0	2	2	0	1	2	1	3	2	2	2	1	2	4	3	1	2	4	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr6:29012395C>T	uc003nlw.2	-	1	558	c.558G>A	c.(556-558)AAG>AAA	p.K186K		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CACAAGCTATCTTGACCAGAG	0.403													8	96					0	0	0	0	T	29012395	T	T	29012395	2	4	259	1	0	0	0	0	0	0	0	1	11086	912	32	2		2	OR2W1	6	29012395	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	16889873	29012395	142102672	77	47107											
DEFB112	245915	broad.mit.edu	37	chr6	50011492	50011492	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttccacctactaaaggtGatatggtgcccttcacttct	9	13	7	12	0	2	1	1	1	1	0	3	2	3	1	3	2	2	0	3	2	4	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr6:50011492G>A	uc011dws.1	-	2	138	c.138C>T	c.(136-138)ATC>ATT	p.I46I		NM_001037498	NP_001032587	Q30KQ8	DB112_HUMAN	beta-defensin 112 precursor	46					defense response to bacterium	extracellular region				central_nervous_system(1)	1	Lung NSC(77;0.042)					TACTAAAGGTGATATGGTGCC	0.403													8	51					0	0	0	0	A	50011492	A	A	50011492	2	1	259	1	0	0	0	0	0	0	0	1	4422	1280	45	2		2	DEFB112	6	50011492	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	20999097	50011492	121103575	78	47108											
PHF3	23469	broad.mit.edu	37	chr6	64394278	64394278	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtatcagtgtcttcaagtCattcttcagtgtcatcttgt	9	17	7	8	0	8	0	5	0	3	0	8	0	8	0	0	0	0	1	0	0	3	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr6:64394278C>T	uc003pep.1	+	3	681	c.655C>T	c.(655-657)CAT>TAT	p.H219Y	PHF3_uc010kaf.1_Missense_Mutation_p.H219Y|PHF3_uc003pem.2_Missense_Mutation_p.H172Y|PHF3_uc010kag.1_Missense_Mutation_p.H131Y|PHF3_uc010kah.1_Missense_Mutation_p.H33Y|PHF3_uc003pen.2_Missense_Mutation_p.H131Y|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.2_Missense_Mutation_p.H219Y	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	219					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			GTCTTCAAGTCATTCTTCAGT	0.393													23	89					0	0	0	0	T	64394278	T	T	64394278	3	4	259	1	0	0	0	0	1	0	0	0	11891	826	29	2	665	2	PHF3	6	64394278	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	14382786	64394278	106720789	79	47109											
MDN1	23195	broad.mit.edu	37	chr6	90459426	90459426	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggggccaaatttaattcatCtaaaataatccaatagcctt	16	12	5	8	0	2	0	1	0	1	0	3	0	3	0	3	2	1	0	3	2	7	7			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr6:90459426C>T	uc003pnn.1	-	25	3567	c.3451G>A	c.(3451-3453)GAT>AAT	p.D1151N		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	1151					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTAATTCATCTAAAATAATC	0.353													22	42					0	0	0	0	T	90459426	T	T	90459426	3	4	259	1	0	0	0	0	1	0	0	0	9468	913	32	2	13651	2	MDN1	6	90459426	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	26065148	90459426	80655641	80	47110											
RFPL4B	442247	broad.mit.edu	37	chr6	112671570	112671570	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacttagaagaaatccagttTtttgatgttgacaataatgt	14	15	8	4	0	0	4	0	2	0	2	1	5	1	4	1	0	0	2	1	0	5	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr6:112671570T>C	uc003pvx.1	+	3	972	c.660T>C	c.(658-660)TTT>TTC	p.F220F		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	220	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		AAATCCAGTTTTTTGATGTTG	0.458													12	55					0	0	0	0	C	112671570	C	C	112671570	2	2	259	1	0	0	0	0	0	0	0	1	13321	1838	64	5		5	RFPL4B	6	112671570	Silent	SNP	T	TCGA-CV-7424-01A-11D-2078-08	22212144	112671570	58443497	81	47111											
PDE10A	10846	broad.mit.edu	37	chr6	165848793	165848793	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagagacggtggtgccctGagtgatgggcccagcaggga	9	5	18	9	1	0	3	0	2	0	1	0	5	0	4	2	4	3	2	2	4	0	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr6:165848793G>T	uc003qun.2	-	7	680	c.439C>A	c.(439-441)CAG>AAG	p.Q147K	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.Q77K|PDE10A_uc003quo.2_Missense_Mutation_p.Q157K	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	147	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GTGGTGCCCTGAGTGATGGGC	0.483													12	23					2.80697e-09	3.09988e-09	1	0	T	165848793	T	T	165848793	3	4	259	1	0	0	0	0	1	0	0	0	11684	1299	45	2	1968	2	PDE10A	6	165848793	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	53177223	165848793	5266274	82	47112											
CCT6A	908	broad.mit.edu	37	chr7	56130445	56130445	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaagaaacagcttcttcactCctggtaagtttgggaaaatg	14	11	9	7	0	2	1	1	0	1	1	3	2	3	2	1	2	2	3	1	2	5	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr7:56130445C>G	uc003trl.1	+	13	1684	c.1520C>G	c.(1519-1521)TCC>TGC	p.S507C	PSPH_uc003trj.2_Intron|CCT6A_uc003trm.1_Missense_Mutation_p.S462C|CCT6A_uc011kcu.1_Missense_Mutation_p.S476C|SUMF2_uc003tro.2_5'Flank|SUMF2_uc011kcv.1_5'Flank|SUMF2_uc011kcw.1_5'Flank|SUMF2_uc011kcx.1_5'Flank|SUMF2_uc003trv.2_5'Flank|SUMF2_uc003trt.2_5'Flank|SUMF2_uc011kcy.1_5'Flank|SUMF2_uc011kcz.1_5'Flank|SUMF2_uc003tru.2_5'Flank|SUMF2_uc011kda.1_5'Flank|SUMF2_uc003trx.2_5'Flank	NM_001762	NP_001753	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A isoform	507					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			upper_aerodigestive_tract(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTTCTTCACTCCTGGTAAGTT	0.378													22	40					0	0	0	0	G	56130445	G	G	56130445	3	3	259	1	0	0	0	0	1	0	0	0	2972	855	30	2	1570	2	CCT6A	7	56130445	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08		56130445	103008218	83	47113											
TAF6	6878	broad.mit.edu	37	chr7	99711749	99711749	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctcctcctgaatctgggcGatgcccatggattcagccac	7	10	10	14	1	3	1	1	1	2	0	5	3	4	2	4	2	2	0	4	2	1	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr7:99711749G>A	uc003uti.2	-	2	165	c.84C>T	c.(82-84)ATC>ATT	p.I28I	TAF6_uc003utg.2_5'Flank|TAF6_uc003uth.2_Silent_p.I85I|TAF6_uc003utk.2_Silent_p.I28I|TAF6_uc011kji.1_Silent_p.I65I|TAF6_uc003utj.2_Silent_p.I28I|TAF6_uc003utl.2_Silent_p.I28I|TAF6_uc003utm.2_Silent_p.I28I|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	28					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAATCTGGGCGATGCCCATGG	0.567													21	111					0	0	0	0	A	99711749	A	A	99711749	2	1	259	1	0	0	0	0	0	0	0	1	15596	1048	37	1		1	TAF6	7	99711749	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	43581304	99711749	59426914	84	47114											
CUX1	1523	broad.mit.edu	37	chr7	101840399	101840399	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgattaagcacaatatcGgacaacgtattttcggacat	14	11	8	8	3	0	1	0	1	0	0	2	3	0	3	0	2	3	3	0	2	5	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr7:101840399G>A	uc003uyx.3	+	15	1746	c.1708G>A	c.(1708-1710)GGA>AGA	p.G570R	CUX1_uc003uys.3_Missense_Mutation_p.G581R|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	570	CUT 1.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GCACAATATCGGACAACGTAT	0.542													58	100					0	0	0	0	A	101840399	A	A	101840399	3	1	259	1	0	0	0	0	1	0	0	0	4081	1117	39	1	1833	1	CUX1	7	101840399	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	2128650	101840399	57298264	85	47115											
GRM8	2918	broad.mit.edu	37	chr7	126173489	126173489	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctaggaagacccgtcggaaGgagcatatgattgtatctgg	11	9	13	8	2	1	2	0	1	1	1	2	5	1	5	2	4	1	2	2	4	5	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr7:126173489G>A	uc003vlr.2	-	8	2258	c.1947C>T	c.(1945-1947)TCC>TCT	p.S649S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.S649S|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	649	Helical; Name=3; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCCGTCGGAAGGAGCATATGA	0.448										HNSCC(24;0.065)			6	68					0	0	0	0	A	126173489	A	A	126173489	2	1	259	1	0	0	0	0	0	0	0	1	6842	987	35	4		4	GRM8	7	126173489	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	24333090	126173489	32965174	86	47116											
LRGUK	136332	broad.mit.edu	37	chr7	133948645	133948645	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaagagtctcaccaacacaGacaacactcggtcccagtca	16	5	6	14	1	2	2	2	0	1	2	5	2	3	2	2	1	2	0	2	1	4	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr7:133948645G>A	uc003vrm.1	+	20	2412	c.2396G>A	c.(2395-2397)AGA>AAA	p.R799K		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	799							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						CACCAACACAGACAACACTCG	0.458													10	56					0	0	0	0	A	133948645	A	A	133948645	3	1	259	1	0	0	0	0	1	0	0	0	8993	942	33	2	2474	2	LRGUK	7	133948645	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	7775156	133948645	25190018	87	47117											
ZNF282	8427	broad.mit.edu	37	chr7	148895756	148895756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagtacgggctgctgcagaGgcggctggagaacttggaga	9	6	19	7	2	0	3	0	0	0	3	0	6	0	4	0	6	4	5	0	6	2	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr7:148895756G>A	uc003wfm.2	+	2	602	c.497G>A	c.(496-498)AGG>AAG	p.R166K	ZNF282_uc011kun.1_Missense_Mutation_p.R166K|ZNF282_uc003wfn.2_Missense_Mutation_p.R106K|ZNF282_uc003wfo.2_Missense_Mutation_p.R106K	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	166					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CTGCTGCAGAGGCGGCTGGAG	0.637													15	60					0	0	0	0	A	148895756	A	A	148895756	3	1	259	1	0	0	0	0	1	0	0	0	17886	1000	35	4	503	4	ZNF282	7	148895756	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	14947111	148895756	10242907	88	47118											
SLC4A2	6522	broad.mit.edu	37	chr7	150771922	150771922	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcttcatggagacacagaTcaccacgtgagtggtcctag	11	9	10	11	1	3	3	2	1	1	2	4	4	4	3	2	2	0	0	2	2	1	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr7:150771922T>A	uc003wit.3	+	19	3297	c.3041T>A	c.(3040-3042)ATC>AAC	p.I1014N	SLC4A2_uc011kve.1_Missense_Mutation_p.I1005N|SLC4A2_uc003wiu.3_Missense_Mutation_p.I1000N|SLC4A2_uc003wiv.3_Missense_Mutation_p.I208N|uc011kvf.1_3'UTR	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	1014	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAGACACAGATCACCACGTGA	0.602													7	10					0	0	0	0	A	150771922	A	A	150771922	3	1	259	1	0	0	0	0	1	0	0	0	14718	1435	50	5	3111	5	SLC4A2	7	150771922	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	1876166	150771922	8366741	89	47119											
AGAP3	116988	broad.mit.edu	37	chr7	150817161	150817161	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccagcgggagctgcgcatcGagaccatcgctgcctcctcc	6	6	12	17	4	0	1	0	0	0	1	4	3	2	2	5	1	4	3	5	1	0	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr7:150817161G>A	uc003wjg.1	+	8	1060	c.1057G>A	c.(1057-1059)GAG>AAG	p.E353K	AGAP3_uc003wje.1_Missense_Mutation_p.E125K|AGAP3_uc003wjf.1_Missense_Mutation_p.E353K|AGAP3_uc010lpy.1_Intron|AGAP3_uc003wjh.1_Missense_Mutation_p.E533K|AGAP3_uc003wji.1_5'Flank	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	317	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						GCTGCGCATCGAGACCATCGC	0.652													26	21					0	0	0	0	A	150817161	A	A	150817161	3	1	259	1	0	0	0	0	1	0	0	0	369	1059	37	1	1087	1	AGAP3	7	150817161	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	45239	150817161	8321502	90	47120											
FBXO25	26260	broad.mit.edu	37	chr8	381402	381402	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcatgaatatgcatcgaaaAaaaggaaaaaggaccatttt	20	8	8	5	1	0	1	0	1	0	0	1	4	0	3	1	2	2	2	1	2	7	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr8:381402A>T	uc003wox.2	+	3	462	c.196A>T	c.(196-198)AAA>TAA	p.K66*	FBXO25_uc003woy.2_Nonsense_Mutation_p.K66*|FBXO25_uc003woz.2_Missense_Mutation_p.K15N	NM_183421	NP_904357	Q8TCJ0	FBX25_HUMAN	F-box only protein 25 isoform 1	66	Interaction with beta-actin.					nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			lung(1)	1		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)		TGCATCGAAAAAAAGGAAAAA	0.249													8	40					0	0	0	0	T	381402	T	T	381402	4	4	259	1	0	0	0	0	0	1	0	0	5768	15	1	5	202	5	FBXO25	8	381402	Nonsense_Mutation	SNP	A	TCGA-CV-7424-01A-11D-2078-08		381402	145982620	91	47121											
LOXL2	4017	broad.mit.edu	37	chr8	23179757	23179757	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataatggacttctcattgccTgtgcactggatctcgttgag	8	14	10	9	1	2	1	1	1	2	0	4	3	2	3	1	2	2	2	1	2	1	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr8:23179757T>G	uc003xdh.1	-	7	1527	c.1188A>C	c.(1186-1188)ACA>ACC	p.T396T	LOXL2_uc010lty.1_5'Flank	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	396	SRCR 3.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TCTCATTGCCTGTGCACTGGA	0.517													25	33					0	0	0	0	G	23179757	G	G	23179757	2	3	259	1	0	0	0	0	0	0	0	1	8950	1567	55	5		5	LOXL2	8	23179757	Silent	SNP	T	TCGA-CV-7424-01A-11D-2078-08	22798355	23179757	123184265	92	47122											
ANK1	286	broad.mit.edu	37	chr8	41543691	41543691	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtttgcgttttggccttcacGgatgacccagaggttcagca	7	12	12	10	2	2	2	2	1	0	1	2	3	2	3	2	3	2	4	2	3	0	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr8:41543691G>A	uc003xok.2	-	36	4453	c.4369C>T	c.(4369-4371)CGT>TGT	p.R1457C	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.R773C|ANK1_uc003xoi.2_Missense_Mutation_p.R1457C|ANK1_uc003xoj.2_Missense_Mutation_p.R1457C|ANK1_uc003xol.2_Missense_Mutation_p.R1457C|ANK1_uc003xom.2_Missense_Mutation_p.R1498C	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1457	55 kDa regulatory domain.|Death.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton	p.R1457H(1)		ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGGCCTTCACGGATGACCCAG	0.522													7	54					0	0	0	0	A	41543691	A	A	41543691	3	1	259	1	0	0	0	0	1	0	0	0	620	1116	39	1	1630	1	ANK1	8	41543691	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	18363934	41543691	104820331	93	47123											
CYP7A1	1581	broad.mit.edu	37	chr8	59407110	59407110	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgcttgactcaaacaaatagGattgccttccaagctgactt	12	12	7	10	0	1	2	1	2	0	0	2	3	2	3	2	1	4	2	2	1	4	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr8:59407110G>C	uc003xtm.3	-	4	1057	c.994C>G	c.(994-996)CCT>GCT	p.P332A		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	332					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				AAACAAATAGGATTGCCTTCC	0.373									Neonatal_Giant_Cell_Hepatitis				18	47					0	0	0	0	C	59407110	C	C	59407110	3	2	259	1	0	0	0	0	1	0	0	0	4213	1174	41	2	532	2	CYP7A1	8	59407110	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	17863419	59407110	86956912	94	47124											
PREX2	80243	broad.mit.edu	37	chr8	68934362	68934362	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caacaaaataagaacaatccGgacatttcttttggtaagtg	16	11	7	7	1	1	1	0	0	1	1	2	2	2	2	1	2	2	1	1	2	7	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr8:68934362G>A	uc003xxv.1	+	4	455	c.428G>A	c.(427-429)CGG>CAG	p.R143Q	PREX2_uc003xxu.1_Missense_Mutation_p.R143Q|PREX2_uc011lez.1_Missense_Mutation_p.R78Q	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	143	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						AGAACAATCCGGACATTTCTT	0.328													23	25					0	0	0	0	A	68934362	A	A	68934362	3	1	259	1	0	0	0	0	1	0	0	0	12539	1116	39	1	442	1	PREX2	8	68934362	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	9527252	68934362	77429660	95	47125											
NCOA2	10499	broad.mit.edu	37	chr8	71069394	71069394	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cacagggcctgatgggcaggGctgttagagctaattggatt	9	10	15	7	0	0	2	0	1	0	1	0	3	0	3	1	4	1	4	1	4	2	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr8:71069394G>A	uc003xyn.1	-	11	1368	c.1206C>T	c.(1204-1206)AGC>AGT	p.S402S		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	402					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GATGGGCAGGGCTGTTAGAGC	0.478			T	RUNXBP2	AML								6	27					0	0	0	0	A	71069394	A	A	71069394	2	1	259	1	0	0	0	0	0	0	0	1	10283	1194	42	4		4	NCOA2	8	71069394	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	2135032	71069394	75294628	96	47126											
SLC30A8	169026	broad.mit.edu	37	chr8	118175721	118175721	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcttttccatcctggtcttgGccagcaccatcactatctta	7	15	5	14	0	4	0	1	0	3	0	6	0	6	0	4	2	1	1	4	2	2	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr8:118175721G>A	uc003yoh.2	+	6	1011	c.781G>A	c.(781-783)GCC>ACC	p.A261T	SLC30A8_uc010mcz.2_Missense_Mutation_p.A212T|SLC30A8_uc011lia.1_Missense_Mutation_p.A212T|SLC30A8_uc003yog.2_Missense_Mutation_p.A212T	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	261	Helical; (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CCTGGTCTTGGCCAGCACCAT	0.398													9	103					0	0	0	0	A	118175721	A	A	118175721	3	1	259	1	0	0	0	0	1	0	0	0	14625	1203	42	4	803	4	SLC30A8	8	118175721	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	47106327	118175721	28188301	97	47127											
COL14A1	7373	broad.mit.edu	37	chr8	121170405	121170405	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttaagatataatgtaatatCtcatgacagtatacagattt	16	15	6	4	0	1	3	1	1	1	2	2	3	1	3	0	0	1	3	0	0	7	8			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr8:121170405C>G	uc003yox.2	+	3	390	c.125C>G	c.(124-126)TCT>TGT	p.S42C		NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	42	Fibronectin type-III 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AATGTAATATCTCATGACAGT	0.343													15	34					0	0	0	0	G	121170405	G	G	121170405	3	3	259	1	0	0	0	0	1	0	0	0	3686	913	32	2	131	2	COL14A1	8	121170405	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	2994684	121170405	25193617	98	47128											
KCNQ3	3786	broad.mit.edu	37	chr8	133192492	133192492	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcgcaggatctgcaggaagCgcaggcttcgcagggaggtg	8	6	18	9	3	1	0	0	0	1	0	2	3	1	3	0	5	3	5	0	5	1	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr8:133192492C>T	uc003ytj.2	-	4	914	c.689G>A	c.(688-690)CGC>CAC	p.R230H	KCNQ3_uc010mdt.2_Missense_Mutation_p.R230H	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	230	Helical; Voltage-sensor; Name=Segment S4; (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CTGCAGGAAGCGCAGGCTTCG	0.587													7	62					0	0	0	0	T	133192492	T	T	133192492	3	4	259	1	0	0	0	0	1	0	0	0	8123	768	27	1	1977	1	KCNQ3	8	133192492	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	12022087	133192492	13171530	99	47129											
COL22A1	169044	broad.mit.edu	37	chr8	139696689	139696689	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttggttcctaggggtccaggGagtccaggtgatccacggag	7	9	16	9	1	0	1	0	1	0	0	4	3	4	3	4	6	0	1	4	6	1	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr8:139696689G>A	uc003yvd.2	-	39	3438	c.2991C>T	c.(2989-2991)CTC>CTT	p.L997L	COL22A1_uc011ljo.1_Silent_p.L297L	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	997	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGGGTCCAGGGAGTCCAGGTG	0.493										HNSCC(7;0.00092)			16	129					0	0	0	0	A	139696689	A	A	139696689	2	1	259	1	0	0	0	0	0	0	0	1	3696	1161	41	2		2	COL22A1	8	139696689	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	6504197	139696689	6667333	100	47130											
CDKN2A	1029	broad.mit.edu	37	chr9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcagctccgccactcGggcgctgcccatcatcatga	8	6	10	17	3	2	1	2	1	0	0	4	1	3	1	3	1	4	4	3	1	0	0	rs121913387		TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			9	4					0	0	0	0	A	21971186	A	A	21971186	4	1	259	1	0	0	0	0	0	1	0	0	3176	1125	39	1	306	1	CDKN2A	9	21971186	Nonsense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		21971186	119242245	101	47131											
TAF1L	138474	broad.mit.edu	37	chr9	32630185	32630185	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccaccatatcccacatcaGagtcacttccactttcactc	10	12	2	17	0	3	1	3	0	0	1	7	1	6	1	4	0	0	0	4	0	1	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:32630185G>A	uc003zrg.1	-	1	5483	c.5393C>T	c.(5392-5394)TCT>TTT	p.S1798F		NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1798					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCCCACATCAGAGTCACTTCC	0.453													12	49					0	0	0	0	A	32630185	A	A	32630185	3	1	259	1	0	0	0	0	1	0	0	0	15589	942	33	2	91	2	TAF1L	9	32630185	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	10658999	32630185	108583246	102	47132											
FBXO10	26267	broad.mit.edu	37	chr9	37537796	37537796	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcccacaaattcacagttttCcaggacacacaggggcacgt	12	7	9	13	1	1	0	1	0	0	0	2	1	2	1	2	3	0	2	2	3	1	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:37537796C>G	uc004aab.2	-	3	779	c.730G>C	c.(730-732)GAA>CAA	p.E244Q	FBXO10_uc004aac.2_Missense_Mutation_p.E260Q|FBXO10_uc004aad.2_Intron	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	244	PbH1 2.					ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		TCACAGTTTTCCAGGACACAC	0.498													5	32					0	0	0	0	G	37537796	G	G	37537796	3	3	259	1	0	0	0	0	1	0	0	0	5758	864	30	2	2176	2	FBXO10	9	37537796	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	4907611	37537796	103675635	103	47133											
WNK2	65268	broad.mit.edu	37	chr9	96021855	96021855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagcccctccagccccacCttcctgaacaagctgctcca	8	7	6	20	0	0	2	0	2	0	0	3	2	3	2	8	0	5	2	8	0	2	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:96021855C>T	uc004ati.1	+	11	3025	c.3025C>T	c.(3025-3027)CTT>TTT	p.L1009F	WNK2_uc011lud.1_Missense_Mutation_p.L1009F|WNK2_uc004atj.2_Missense_Mutation_p.L1009F|WNK2_uc004atk.2_Missense_Mutation_p.L646F|WNK2_uc010mrc.1_Missense_Mutation_p.L957F	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1009					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CCAGCCCCACCTTCCTGAACA	0.687													3	8					0	0	0	0	T	96021855	T	T	96021855	3	4	259	1	0	0	0	0	1	0	0	0	17446	681	24	4	3067	4	WNK2	9	96021855	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	58484059	96021855	45191576	104	47134											
PTCH1	5727	broad.mit.edu	37	chr9	98242784	98242784	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttattcagcatttcctccCagctgtccacttgatagttt	7	16	5	13	0	1	1	1	1	0	0	4	1	4	1	4	0	2	3	4	0	2	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:98242784C>T	uc004avk.3	-	6	1021	c.833G>A	c.(832-834)TGG>TAG	p.W278*	PTCH1_uc010mro.2_Nonsense_Mutation_p.W127*|PTCH1_uc010mrp.2_Nonsense_Mutation_p.W127*|PTCH1_uc010mrq.2_Nonsense_Mutation_p.W127*|PTCH1_uc004avl.3_Nonsense_Mutation_p.W127*|PTCH1_uc010mrr.2_Nonsense_Mutation_p.W212*|PTCH1_uc004avm.3_Nonsense_Mutation_p.W277*|PTCH1_uc010mrs.1_5'UTR|PTCH1_uc010mrt.1_RNA|PTCH1_uc010mru.1_RNA	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	278	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.W278*(2)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CATTTCCTCCCAGCTGTCCAC	0.498									Basal_Cell_Nevus_syndrome				51	42					0	0	0	0	T	98242784	T	T	98242784	4	4	259	1	0	0	0	0	0	1	0	0	12792	595	21	4	3582	4	PTCH1	9	98242784	Nonsense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	2220929	98242784	42970647	105	47135											
STX17	55014	broad.mit.edu	37	chr9	102677620	102677620	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagacctggaaaggttaagAaagcaccagataaatattga	19	7	9	6	0	0	4	0	1	0	3	0	5	0	5	2	2	1	2	2	2	6	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:102677620A>C	uc004bal.3	+	2	235	c.99A>C	c.(97-99)AGA>AGC	p.R33S	STX17_uc004bak.2_Missense_Mutation_p.R33S|STX17_uc010msx.2_RNA|STX17_uc011lvd.1_RNA	NM_017919	NP_060389	P56962	STX17_HUMAN	syntaxin 17	33	Cytoplasmic (Potential).				intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum|integral to membrane|nucleolus	SNAP receptor activity			large_intestine(1)	1		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				AAAGGTTAAGAAAGCACCAGA	0.343													16	34					0	0	0	0	C	102677620	C	C	102677620	3	2	259	1	0	0	0	0	1	0	0	0	15406	243	9	5	101	5	STX17	9	102677620	Missense_Mutation	SNP	A	TCGA-CV-7424-01A-11D-2078-08	4434836	102677620	38535811	106	47136											
SLC44A1	23446	broad.mit.edu	37	chr9	108110642	108110642	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatttttctttcaacaggttCagccctatgtagctacaacc	11	14	5	11	0	3	0	2	0	1	0	3	0	3	0	2	1	5	3	2	1	6	7			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:108110642C>G	uc004bcn.2	+	5	631	c.410C>G	c.(409-411)TCA>TGA	p.S137*	SLC44A1_uc010mtk.1_Nonsense_Mutation_p.S137*	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	137	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	TCAACAGGTTCAGCCCTATGT	0.353													6	53					0	0	0	0	G	108110642	G	G	108110642	4	3	259	1	0	0	0	0	0	1	0	0	14699	838	29	2	428	2	SLC44A1	9	108110642	Nonsense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	5433022	108110642	33102789	107	47137											
ZFP37	7539	broad.mit.edu	37	chr9	115818900	115818900	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgcccggcctctttggtcgtTtccgcacttctcctccggtc	1	13	9	18	5	2	0	0	0	2	0	7	0	4	0	5	3	0	2	5	3	0	3	rs144129779		TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:115818900T>G	uc004bgm.1	-	1	97	c.69A>C	c.(67-69)GAA>GAC	p.E23D	ZFP37_uc011lwz.1_Missense_Mutation_p.E23D|ZFP37_uc011lxa.1_Missense_Mutation_p.E23D	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	23						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CTTTGGTCGTTTCCGCACTTC	0.652													18	116					0	0	0	0	G	115818900	G	G	115818900	3	3	259	1	0	0	0	0	1	0	0	0	17715	1838	64	5	1839	5	ZFP37	9	115818900	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	7708258	115818900	25394531	108	47138											
COL27A1	85301	broad.mit.edu	37	chr9	116930469	116930469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgcagtccagtttgaaggtGctctctgccagttcagtatc	8	13	10	10	0	2	1	1	1	1	0	5	1	3	1	2	1	3	5	2	1	2	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:116930469G>A	uc011lxl.1	+	3	634	c.634G>A	c.(634-636)GCT>ACT	p.A212T	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.A62T	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	212	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GTTTGAAGGTGCTCTCTGCCA	0.582													6	58					0	0	0	0	A	116930469	A	A	116930469	3	1	259	1	0	0	0	0	1	0	0	0	3700	1319	46	4	644	4	COL27A1	9	116930469	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	1111569	116930469	24282962	109	47139											
CEP110	11064	broad.mit.edu	37	chr9	123914854	123914854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagagcatccaagcggcagtCggagaaagaaatggaagaac	17	3	14	7	2	0	4	0	0	0	4	2	7	1	5	1	3	3	2	1	3	5	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:123914854C>T	uc004bkx.1	+	24	4086	c.4055C>T	c.(4054-4056)TCG>TTG	p.S1352L	CEP110_uc004bla.1_Missense_Mutation_p.S800L|CEP110_uc010mvo.1_Missense_Mutation_p.S21L|CEP110_uc004blb.1_Missense_Mutation_p.S21L	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1352	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AAGCGGCAGTCGGAGAAAGAA	0.383													25	36					0	0	0	0	T	123914854	T	T	123914854	3	4	259	1	0	0	0	0	1	0	0	0	3260	893	31	1	4149	1	CEP110	9	123914854	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	6984385	123914854	17298577	110	47140											
TTF1	7270	broad.mit.edu	37	chr9	135251352	135251363	+	In_Frame_Del	DEL	GAGCCATGCATG	-	-																															agtactggaattacaggcgtGagccatgcatggcgcctggc																										TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:135251352_135251363delGAGCCATGCATG	uc004cbl.2	-	11	2709_2720	c.2657_2668delCATGCATGGCTC	c.(2656-2670)CCATGCATGGCTCAC>CAC	p.PCMA886del	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_In_Frame_Del_p.PCMA371del	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	886_889					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ttacaggcgtgagccatgcatggcgcctggcc	0.175													---	---	---								-	135251363	-	-	135251352	7	5	259	1	0	1	0	1	0	0	0	0	16786	1290	45	0	53	0	TTF1	9	135251352	In_Frame_Del	DEL	GAGCCATGCATG	TCGA-CV-7424-01A-11D-2078-08	11336498	135251352	5962079	111	47141											
NOTCH1	4851	broad.mit.edu	37	chr9	139405241	139405241	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaacgcactcgttgatgtcGacctcacaggtctgccctgc	8	9	10	14	3	2	2	1	1	1	1	4	3	2	2	2	1	3	2	2	1	1	1	rs115235667	by1000genomes	TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr9:139405241G>A	uc004chz.2	-	17	2604	c.2604C>T	c.(2602-2604)GTC>GTT	p.V868V	NOTCH1_uc004cia.1_Silent_p.V98V	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	868	Extracellular (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGTTGATGTCGACCTCACAGG	0.706			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			24	12					0	0	0	0	A	139405241	A	A	139405241	2	1	259	1	0	0	0	0	0	0	0	1	10601	1045	37	1		1	NOTCH1	9	139405241	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	4153889	139405241	1808190	112	47142											
GAD2	2572	broad.mit.edu	37	chr10	26581498	26581498	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tatgagatggtgtttgatggGaaggtatgtatttggatttc	9	17	14	1	0	0	2	0	2	0	1	1	5	0	4	0	4	0	3	0	4	4	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr10:26581498G>A	uc001isp.2	+	14	1994	c.1491G>A	c.(1489-1491)GGG>GGA	p.G497G	GAD2_uc001isq.2_Silent_p.G497G	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	497					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TGTTTGATGGGAAGGTATGTA	0.388													8	35					0	0	0	0	A	26581498	A	A	26581498	2	1	259	1	0	0	0	0	0	0	0	1	6214	1161	41	2		2	GAD2	10	26581498	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08		26581498	108953249	113	47143											
ZNF438	220929	broad.mit.edu	37	chr10	31138093	31138093	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttggggatcattttttactCtttctttaccatctctacac	7	19	4	11	0	4	0	1	0	3	0	5	1	4	1	1	2	3	0	1	2	3	8			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr10:31138093C>G	uc010qdz.1	-	7	1676	c.1241G>C	c.(1240-1242)AGA>ACA	p.R414T	ZNF438_uc001ivn.2_Missense_Mutation_p.R365T|ZNF438_uc010qdy.1_Missense_Mutation_p.R404T|ZNF438_uc001ivo.3_5'UTR|ZNF438_uc009xlg.2_Missense_Mutation_p.R414T|ZNF438_uc001ivp.3_Missense_Mutation_p.R404T|ZNF438_uc010qea.1_Missense_Mutation_p.R414T|ZNF438_uc010qeb.1_Missense_Mutation_p.R414T|ZNF438_uc010qec.1_5'UTR	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				ATTTTTTACTCTTTCTTTACC	0.378													9	43					0	0	0	0	G	31138093	G	G	31138093	3	3	259	1	0	0	0	0	1	0	0	0	17977	913	32	2	1253	2	ZNF438	10	31138093	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	4556595	31138093	104396654	114	47144											
ANKRD30A	91074	broad.mit.edu	37	chr10	37431034	37431034	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcccgcaaaagaaacatcTgagaaatttacgtgggcagc	15	7	10	9	2	1	2	0	1	1	2	2	3	2	2	1	1	3	2	1	1	5	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr10:37431034T>G	uc001iza.1	+	7	1140	c.1041T>G	c.(1039-1041)TCT>TCG	p.S347S		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	403						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AAGAAACATCTGAGAAATTTA	0.433													9	58					0	0	0	0	G	37431034	G	G	37431034	2	3	259	1	0	0	0	0	0	0	0	1	658	1567	55	5		5	ANKRD30A	10	37431034	Silent	SNP	T	TCGA-CV-7424-01A-11D-2078-08	6292941	37431034	98103713	115	47145											
BMS1	9790	broad.mit.edu	37	chr10	43285840	43285840	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtttctaaacatctgtcaaGtacatggctttcctaaaatt	13	15	5	8	0	3	0	1	0	2	0	4	0	4	0	1	1	2	3	1	1	6	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr10:43285840G>A	uc001jaj.2	+	5	875	c.517G>A	c.(517-519)GTA>ATA	p.V173I		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	173					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						CATCTGTCAAGTACATGGCTT	0.378													24	71					0	0	0	0	A	43285840	A	A	43285840	3	1	259	1	0	0	0	0	1	0	0	0	1475	1029	36	4	531	4	BMS1	10	43285840	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	5854806	43285840	92248907	116	47146											
OR13A1	79290	broad.mit.edu	37	chr10	45799763	45799763	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acccggtattctgggtgctcCgaaaagccctgcaggatgaa	10	8	12	11	2	1	1	0	1	1	0	2	3	2	2	3	3	3	3	3	3	4	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr10:45799763C>T	uc001jcc.1	-	4	417	c.108G>A	c.(106-108)TCG>TCA	p.S36S	OR13A1_uc001jcd.1_Silent_p.S32S	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	36	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGGGTGCTCCGAAAAGCCCT	0.527													5	24					0	0	0	0	T	45799763	T	T	45799763	2	4	259	1	0	0	0	0	0	0	0	1	10987	639	23	1		1	OR13A1	10	45799763	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	2513923	45799763	89734984	117	47147											
C10orf72	196740	broad.mit.edu	37	chr10	50285363	50285363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacacgaggacagcatacaCatagagatctgaaaggcaag	17	4	11	9	1	1	2	0	1	1	1	1	5	1	3	0	2	2	3	0	2	4	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr10:50285363C>T	uc001jhf.2	-	4	564	c.535G>A	c.(535-537)GTG>ATG	p.V179M		NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	179	Extracellular (Potential).					integral to membrane|plasma membrane					0						ACAGCATACACATAGAGATCT	0.512													6	25					0	0	0	0	T	50285363	T	T	50285363	3	4	259	1	0	0	0	0	1	0	0	0	1621	478	17	4	447	4	C10orf72	10	50285363	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	4485600	50285363	85249384	118	47148											
OGDHL	55753	broad.mit.edu	37	chr10	50946288	50946288	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcaggaacctttcgggcctCgctgacgagtgctctgggcc	5	9	14	13	3	1	1	0	1	1	0	3	3	1	2	3	3	3	3	3	3	1	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr10:50946288C>T	uc001jie.2	-	18	2482	c.2340G>A	c.(2338-2340)GCG>GCA	p.A780A	OGDHL_uc009xog.2_Silent_p.A807A|OGDHL_uc010qgt.1_Silent_p.A723A|OGDHL_uc010qgu.1_Silent_p.A571A	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	780					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						TTTCGGGCCTCGCTGACGAGT	0.617													4	27					0	0	0	0	T	50946288	T	T	50946288	2	4	259	1	0	0	0	0	0	0	0	1	10894	871	31	1		1	OGDHL	10	50946288	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	660925	50946288	84588459	119	47149											
HK1	3098	broad.mit.edu	37	chr10	71103643	71103643	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctcatagatatcatgactCgcttcaggaaggagatgaag	13	10	10	8	1	3	4	3	2	1	2	5	6	3	5	0	2	0	1	0	2	4	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr10:71103643C>T	uc001jpl.3	+	2	225	c.124C>T	c.(124-126)CGC>TGC	p.R42C	HK1_uc009xqc.1_3'UTR|HK1_uc001jpg.3_Missense_Mutation_p.R30C|HK1_uc001jph.3_Missense_Mutation_p.R46C|HK1_uc001jpi.3_Missense_Mutation_p.R46C|HK1_uc001jpj.3_Missense_Mutation_p.R77C|HK1_uc001jpk.3_Missense_Mutation_p.R41C|HK1_uc009xqd.2_5'UTR	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	42	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						TATCATGACTCGCTTCAGGAA	0.498													8	112					0	0	0	0	T	71103643	T	T	71103643	3	4	259	1	0	0	0	0	1	0	0	0	7229	884	31	1	308	1	HK1	10	71103643	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	20157355	71103643	64431104	120	47150											
PNLIPRP2	5408	broad.mit.edu	37	chr10	118396336	118396336	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgaaggatgccccaaaaTggggcactatgctgaccaat	13	7	11	10	0	0	2	0	2	0	0	0	3	0	3	3	3	3	3	3	3	5	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr10:118396336T>C	uc001lcq.2	+	12	1003	c.980T>C	c.(979-981)ATG>ACG	p.M327T	PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	326					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		TGCCCCAAAATGGGGCACTAT	0.403													5	9					0	0	0	0	C	118396336	C	C	118396336	3	2	259	1	0	0	0	0	1	0	0	0	12206	1464	51	5	1017	5	PNLIPRP2	10	118396336	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	47292693	118396336	17138411	121	47151											
C10orf82	143379	broad.mit.edu	37	chr10	118425293	118425293	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcacacagtggttcatgtCatcctccttggacattcctt	7	16	6	12	0	3	0	3	0	0	0	6	1	6	1	3	2	0	1	3	2	0	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr10:118425293C>G	uc001lcr.2	-	3	155	c.100G>C	c.(100-102)GAC>CAC	p.D34H	C10orf82_uc001lcs.1_Missense_Mutation_p.D34H	NM_144661	NP_653262	Q8WW14	CJ082_HUMAN	hypothetical protein LOC143379	34											0				all cancers(201;0.0143)		TGGTTCATGTCATCCTCCTTG	0.517													8	39					0	0	0	0	G	118425293	G	G	118425293	3	3	259	1	0	0	0	0	1	0	0	0	1626	826	29	2	376	2	C10orf82	10	118425293	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	28957	118425293	17109454	122	47152											
OR51B2	79345	broad.mit.edu	37	chr11	5345347	5345347	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcctgccagcatggtgaGgaagtagtacatgggctcat	9	10	14	8	0	1	1	1	1	0	0	1	2	1	2	2	3	4	4	2	3	3	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:5345347G>A	uc001mao.1	-	1	236	c.181C>T	c.(181-183)CTC>TTC	p.L61F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCATGGTGAGGAAGTAGTAC	0.512													9	66					0	0	0	0	A	5345347	A	A	5345347	3	1	259	1	0	0	0	0	1	0	0	0	11143	1000	35	4	761	4	OR51B2	11	5345347	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		5345347	129661169	123	47153											
LRRC4C	57689	broad.mit.edu	37	chr11	40136643	40136643	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgagcacagctatccgcacTttgtacgccccatgtgtcat	8	11	8	14	2	1	1	1	1	0	0	2	1	2	1	3	0	3	4	3	0	2	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:40136643T>A	uc001mxa.1	-	2	3164	c.1200A>T	c.(1198-1200)AAA>AAT	p.K400N	LRRC4C_uc001mxc.1_Missense_Mutation_p.K396N|LRRC4C_uc001mxd.1_Missense_Mutation_p.K396N|LRRC4C_uc001mxb.1_Missense_Mutation_p.K396N	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	400	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CTATCCGCACTTTGTACGCCC	0.463													25	132					0	0	0	0	A	40136643	A	A	40136643	3	1	259	1	0	0	0	0	1	0	0	0	9058	1606	56	5	726	5	LRRC4C	11	40136643	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	34791296	40136643	94869873	124	47154											
LRP4	4038	broad.mit.edu	37	chr11	46900560	46900560	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacacaggtggctacagcCgccattctccatagcacatg	12	7	9	13	1	1	1	0	0	1	1	2	1	1	1	3	2	3	2	3	2	3	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:46900560C>T	uc001ndn.3	-	22	3180	c.3034G>A	c.(3034-3036)GGC>AGC	p.G1012S		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1012	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		TGGCTACAGCCGCCATTCTCC	0.567													9	148					0	0	0	0	T	46900560	T	T	46900560	3	4	259	1	0	0	0	0	1	0	0	0	9009	652	23	1	2751	1	LRP4	11	46900560	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	6763917	46900560	88105956	125	47155											
OR4C46	119749	broad.mit.edu	37	chr11	51515672	51515672	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgcaagcccttgcactatAtgactatcatgaaccagtgt	11	12	7	11	0	2	2	1	2	1	0	2	2	2	2	2	0	4	2	2	0	5	4	rs140334906		TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:51515672A>C	uc010ric.1	+	1	391	c.391A>C	c.(391-393)ATG>CTG	p.M131L		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTTGCACTATATGACTATCAT	0.478													31	69					0	0	0	0	C	51515672	C	C	51515672	3	2	259	1	0	0	0	0	1	0	0	0	11105	449	16	5	393	5	OR4C46	11	51515672	Missense_Mutation	SNP	A	TCGA-CV-7424-01A-11D-2078-08	4615112	51515672	83490844	126	47156											
OR5L1	219437	broad.mit.edu	37	chr11	55579363	55579363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaccatgtcttggaaggtgCgtgtggagctggcttcttgc	5	13	14	9	1	3	0	1	0	2	0	3	2	3	2	1	4	3	2	1	4	1	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:55579363C>T	uc001nhw.1	+	1	421	c.421C>T	c.(421-423)CGT>TGT	p.R141C		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TTGGAAGGTGCGTGTGGAGCT	0.498													15	64					0	0	0	0	T	55579363	T	T	55579363	3	4	259	1	0	0	0	0	1	0	0	0	11224	768	27	1	423	1	OR5L1	11	55579363	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	4063691	55579363	79427153	127	47157											
OR5R1	219479	broad.mit.edu	37	chr11	56185142	56185142	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccttcatgtgtgtgtctgaGcaggacagagctaagaaggg	10	10	14	7	0	2	3	1	1	1	2	3	4	3	4	1	2	2	2	1	2	2	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:56185142G>A	uc010rji.1	-	1	567	c.567C>T	c.(565-567)TGC>TGT	p.C189C		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GTGTGTCTGAGCAGGACAGAG	0.428													5	43					0	0	0	0	A	56185142	A	A	56185142	2	1	259	1	0	0	0	0	0	0	0	1	11234	963	34	4		4	OR5R1	11	56185142	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	605779	56185142	78821374	128	47158											
OR10W1	81341	broad.mit.edu	37	chr11	58034658	58034658	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtggagaaggcccggtggcGgccagcagccgagtggatct	7	5	19	10	3	1	1	0	0	1	1	1	4	1	2	3	7	2	1	3	7	1	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:58034658G>T	uc001nmq.1	-	1	1075	c.673C>A	c.(673-675)CGC>AGC	p.R225S		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				GCCCGGTGGCGGCCAGCAGCC	0.587													6	43					2.17888e-05	2.33517e-05	1	0	T	58034658	T	T	58034658	3	4	259	1	0	0	0	0	1	0	0	0	10975	1116	39	3	248	3	OR10W1	11	58034658	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	1849516	58034658	76971858	129	47159											
RTN3	10313	broad.mit.edu	37	chr11	63517599	63517599	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctggctcttctctctgtCaccatcagcttcaggatcta	7	14	6	14	0	7	0	3	0	4	0	9	1	8	1	2	2	1	2	2	2	1	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:63517599C>T	uc001nxq.2	+	4	2854	c.2667C>T	c.(2665-2667)GTC>GTT	p.V889V	RTN3_uc001nxo.2_Silent_p.V93V|RTN3_uc001nxm.2_Silent_p.V112V|RTN3_uc001nxn.2_Silent_p.V870V|RTN3_uc001nxp.2_Silent_p.V93V|RTN3_uc009yov.2_Silent_p.V777V|RTN3_uc010rmt.1_RNA|RTN3_uc010rmu.1_Silent_p.V93V	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	889	Reticulon.				apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						TTCTCTCTGTCACCATCAGCT	0.473													5	9					0	0	0	0	T	63517599	T	T	63517599	2	4	259	1	0	0	0	0	0	0	0	1	13792	813	29	2		2	RTN3	11	63517599	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	5482941	63517599	71488917	130	47160											
C2CD3	26005	broad.mit.edu	37	chr11	73789513	73789513	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caagcagcacacaatggatgGgcagccacagccttggggtg	11	5	14	11	0	0	0	0	0	0	0	0	1	0	1	2	4	4	3	2	4	2	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:73789513G>A	uc001ouu.2	-	23	4477	c.4250C>T	c.(4249-4251)CCC>CTC	p.P1417L	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1417				P -> S (in Ref. 1; BAE17137).		centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					ACAATGGATGGGCAGCCACAG	0.493													18	41					0	0	0	0	A	73789513	A	A	73789513	3	1	259	1	0	0	0	0	1	0	0	0	2164	1232	43	4	1677	4	C2CD3	11	73789513	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	10271914	73789513	61217003	131	47161											
MOGAT2	80168	broad.mit.edu	37	chr11	75439149	75439149	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatccttcacgctgttactgCggaaccgaaagggcttcgtc	8	10	11	12	4	1	0	1	0	0	0	4	3	2	1	2	2	3	3	2	2	3	3	rs144185928		TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:75439149C>T	uc010rru.1	+	4	610	c.610C>T	c.(610-612)CGG>TGG	p.R204W	MOGAT2_uc001oww.1_Missense_Mutation_p.R204W|MOGAT2_uc010rrv.1_Missense_Mutation_p.R122W	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	204					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					GCTGTTACTGCGGAACCGAAA	0.562													5	28					0	0	0	0	T	75439149	T	T	75439149	3	4	259	1	0	0	0	0	1	0	0	0	9748	759	27	1	624	1	MOGAT2	11	75439149	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	1649636	75439149	59567367	132	47162											
SYTL2	54843	broad.mit.edu	37	chr11	85456724	85456724	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttctggctcttctacaacGccagccagctctggaggaag	8	10	10	13	1	5	0	0	0	5	0	5	2	5	2	2	3	4	2	2	3	3	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:85456724G>A	uc010rth.1	-	3	621	c.345C>T	c.(343-345)GGC>GGT	p.G115G	SYTL2_uc010rtg.1_Silent_p.G115G|SYTL2_uc010rti.1_Silent_p.G115G|SYTL2_uc010rtj.1_Silent_p.G67G|SYTL2_uc001pbf.3_Silent_p.G115G	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	115					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CTTCTACAACGCCAGCCAGCT	0.517													7	78					0	0	0	0	A	85456724	A	A	85456724	2	1	259	1	0	0	0	0	0	0	0	1	15549	1074	38	1		1	SYTL2	11	85456724	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	10017575	85456724	49549792	133	47163											
DYNC2H1	79659	broad.mit.edu	37	chr11	103029735	103029735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccatcagtgattcagtctCacctgaagaagctttttgct	10	13	7	11	0	3	3	3	2	1	1	4	3	3	3	2	0	2	2	2	0	2	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr11:103029735C>T	uc001pho.2	+	28	4501	c.4357C>T	c.(4357-4359)CAC>TAC	p.H1453Y	DYNC2H1_uc001phn.1_Missense_Mutation_p.H1453Y|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1453	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GATTCAGTCTCACCTGAAGAA	0.254													3	21					0	0	0	0	T	103029735	T	T	103029735	3	4	259	1	0	0	0	0	1	0	0	0	4868	826	29	2	4467	2	DYNC2H1	11	103029735	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	17573011	103029735	31976781	134	47164											
FGF23	8074	broad.mit.edu	37	chr12	4479716	4479716	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggggtcccgctccgagtcGtcctcggcgctccgggtgtg	2	8	17	14	6	0	0	0	0	0	0	6	1	4	0	4	4	0	2	4	4	0	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr12:4479716G>A	uc001qmq.1	-	3	695	c.549C>T	c.(547-549)GAC>GAT	p.D183D		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	183					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			GCTCCGAGTCGTCCTCGGCGC	0.682													9	36					0	0	0	0	A	4479716	A	A	4479716	2	1	259	1	0	0	0	0	0	0	0	1	5884	1136	40	1		1	FGF23	12	4479716	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08		4479716	129372179	135	47165											
C12orf36	283422	broad.mit.edu	37	chr12	13529255	13529255	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatagtggagcatgaagtgtCttcatcaggaacacacagaa	16	8	10	7	0	3	2	2	1	1	1	3	4	3	4	0	2	2	1	0	2	5	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr12:13529255C>T	uc001rbs.1	-	2	303	c.85G>A	c.(85-87)GAC>AAC	p.D29N		NM_182558	NP_872364			hypothetical protein LOC283422												0				BRCA - Breast invasive adenocarcinoma(232;0.198)		catgaagtgtcttcatcagga	0.06													5	16					0	0	0	0	T	13529255	T	T	13529255	3	4	259	1	0	0	0	0	1	0	0	0	1689	913	32	2	339	2	C12orf36	12	13529255	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	9049539	13529255	120322640	136	47166											
SLCO1C1	53919	broad.mit.edu	37	chr12	20905254	20905254	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttctagacatatatatctggGactaactgtgatactgggca	12	13	9	7	0	2	2	0	1	2	1	2	3	2	3	0	2	2	1	0	2	6	7			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr12:20905254G>A	uc001rej.3	+	16	2286	c.1931G>A	c.(1930-1932)GGA>GAA	p.G644E	SLCO1C1_uc010sii.1_Silent_p.G678G|SLCO1C1_uc010sij.1_Missense_Mutation_p.G595E|SLCO1C1_uc009zip.2_Silent_p.G512G|SLCO1C1_uc001rei.2_Missense_Mutation_p.G644E|SLCO1C1_uc010sik.1_Silent_p.G560G	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	644	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					ATATATCTGGGACTAACTGTG	0.303													4	23					0	0	0	0	A	20905254	A	A	20905254	3	1	259	1	0	0	0	0	1	0	0	0	14789	1174	41	2	2088	2	SLCO1C1	12	20905254	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	7375999	20905254	112946641	137	47167											
ACCN2	41	broad.mit.edu	37	chr12	50471784	50471784	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactcctcattcccctagaCgagacgtccttcgaagcagg	10	8	8	15	3	1	2	1	0	0	2	5	4	4	2	4	1	1	1	4	1	2	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr12:50471784C>T	uc001rvw.2	+	5	940	c.711C>T	c.(709-711)GAC>GAT	p.D237D	ACCN2_uc001rvv.2_Silent_p.D237D|ACCN2_uc009zln.2_Silent_p.D28D|ACCN2_uc009zlo.2_Silent_p.D237D	NM_001095	NP_001086	P78348	ACCN2_HUMAN	amiloride-sensitive cation channel 2, neuronal	237	Extracellular (By similarity).				calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)	TTCCCCTAGACGAGACGTCCT	0.567													12	69					0	0	0	0	T	50471784	T	T	50471784	2	4	259	1	0	0	0	0	0	0	0	1	129	550	19	1		1	ACCN2	12	50471784	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	29566530	50471784	83380111	138	47168											
R3HDM2	22864	broad.mit.edu	37	chr12	57660592	57660592	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtactgctcagagccaggggGttgcagaaaccctacagaag	12	6	13	10	0	1	3	1	0	0	3	1	3	1	3	2	2	6	4	2	2	4	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr12:57660592G>A	uc009zpm.1	-	17	2046	c.2011C>T	c.(2011-2013)CCC>TCC	p.P671S	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_Missense_Mutation_p.P366S|R3HDM2_uc001snr.2_Missense_Mutation_p.P398S|R3HDM2_uc001sns.2_Missense_Mutation_p.P671S|R3HDM2_uc001snt.2_Missense_Mutation_p.P685S|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	671	Gln-rich.					nucleus	nucleic acid binding			ovary(2)	2						GAGCCAGGGGGTTGCAGAAAC	0.552													5	16					0	0	0	0	A	57660592	A	A	57660592	3	1	259	1	0	0	0	0	1	0	0	0	12953	1261	44	4	943	4	R3HDM2	12	57660592	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	7188808	57660592	76191303	139	47169											
NAV3	89795	broad.mit.edu	37	chr12	78516145	78516145	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttgtctggactgaccacagGcactcacgaggtccagagcc	9	7	11	14	1	2	2	1	1	1	1	3	4	3	3	3	3	1	1	3	3	0	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr12:78516145G>A	uc001syp.2	+	16	4348	c.4175G>A	c.(4174-4176)GGC>GAC	p.G1392D	NAV3_uc001syo.2_Missense_Mutation_p.G1392D|NAV3_uc010sub.1_Missense_Mutation_p.G892D|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1392	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTGACCACAGGCACTCACGAG	0.547										HNSCC(70;0.22)			14	79					0	0	0	0	A	78516145	A	A	78516145	3	1	259	1	0	0	0	0	1	0	0	0	10238	1203	42	4	4237	4	NAV3	12	78516145	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	20855553	78516145	55335750	140	47170											
ACACB	32	broad.mit.edu	37	chr12	109660402	109660402	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcaaaagcgagcactgcAaagtggccctcagagcccgg	12	4	13	12	2	1	2	1	1	0	1	1	3	1	2	2	2	5	3	2	2	3	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr12:109660402A>G	uc001tob.2	+	25	3774	c.3655A>G	c.(3655-3657)AAA>GAA	p.K1219E	ACACB_uc001toc.2_Missense_Mutation_p.K1219E	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1219					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CGAGCACTGCAAAGTGGCCCT	0.622													7	26					0	0	0	0	G	109660402	G	G	109660402	3	3	259	1	0	0	0	0	1	0	0	0	107	131	5	5	3749	5	ACACB	12	109660402	Missense_Mutation	SNP	A	TCGA-CV-7424-01A-11D-2078-08	31144257	109660402	24191493	141	47171											
TUBA3C	7278	broad.mit.edu	37	chr13	19751321	19751321	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggggcgtaggtggccagggGgaagtggatgcgggggtacg	6	5	24	6	4	0	0	0	0	0	0	0	2	0	2	1	9	2	2	1	9	3	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr13:19751321G>C	uc009zzj.2	-	4	851	c.802C>G	c.(802-804)CCC>GCC	p.P268A		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	268					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GTGGCCAGGGGGAAGTGGATG	0.617													32	80					0	0	0	0	C	19751321	C	C	19751321	3	2	259	1	0	0	0	0	1	0	0	0	16814	1232	43	4	558	4	TUBA3C	13	19751321	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		19751321	95418557	142	47172											
SPATA13	221178	broad.mit.edu	37	chr13	24868931	24868931	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaagaatgtggcctgtctGatcaacgagcgcaagcgcaa	13	7	12	9	3	2	3	1	2	1	1	2	4	2	3	1	1	3	2	1	1	5	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr13:24868931G>A	uc001upg.1	+	9	1667	c.1260G>A	c.(1258-1260)CTG>CTA	p.L420L	SPATA13_uc001upd.1_Silent_p.L1045L|C1QTNF9_uc001upe.2_RNA|SPATA13_uc010tcy.1_Silent_p.L366L|SPATA13_uc010tcz.1_Silent_p.L304L|SPATA13_uc010tda.1_Silent_p.L364L|SPATA13_uc001uph.2_Silent_p.L342L|SPATA13_uc010tdb.1_Silent_p.L280L|SPATA13_uc009zzz.1_Intron|SPATA13_uc001upi.1_5'Flank	NM_153023	NP_694568	Q96N96	SPT13_HUMAN	spermatogenesis associated 13	420	DH.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		TGGCCTGTCTGATCAACGAGC	0.488													11	47					0	0	0	0	A	24868931	A	A	24868931	2	1	259	1	0	0	0	0	0	0	0	1	15066	1277	45	2		2	SPATA13	13	24868931	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	5117610	24868931	90300947	143	47173											
FLT1	2321	broad.mit.edu	37	chr13	28959121	28959121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtggtggaactgctgatggCcactgtgtgatcactgaggt	8	11	15	7	0	1	3	1	3	0	0	1	4	1	4	1	4	2	1	1	4	1	0	rs137937570		TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr13:28959121C>T	uc001usb.3	-	14	2302	c.2017G>A	c.(2017-2019)GCC>ACC	p.A673T	FLT1_uc010aar.1_Missense_Mutation_p.A673T	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	673	Ig-like C2-type 7.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTGCTGATGGCCACTGTGTGA	0.448													25	70					0	0	0	0	T	28959121	T	T	28959121	3	4	259	1	0	0	0	0	1	0	0	0	5973	739	26	4	2157	4	FLT1	13	28959121	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	4090190	28959121	86210757	144	47174											
PDS5B	23047	broad.mit.edu	37	chr13	33247377	33247377	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaatcaggttctgatgcttGggaaaacatctatcagcgat	12	13	9	7	1	4	1	2	1	2	0	4	3	4	2	0	2	3	2	0	2	4	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr13:33247377G>C	uc010abf.2	+	8	888	c.730G>C	c.(730-732)GGG>CGG	p.G244R	PDS5B_uc001uuo.2_Missense_Mutation_p.G244R|PDS5B_uc010abg.2_RNA|PDS5B_uc010teb.1_5'Flank	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	244					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		TCTGATGCTTGGGAAAACATC	0.353													18	49					0	0	0	0	C	33247377	C	C	33247377	3	2	259	1	0	0	0	0	1	0	0	0	11746	1348	47	4	756	4	PDS5B	13	33247377	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	4288256	33247377	81922501	145	47175											
OR4N2	390429	broad.mit.edu	37	chr14	20295797	20295797	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccccctctatttctttctgGgcaacttggccttcctggat	4	15	7	15	0	3	0	0	0	3	0	4	1	4	1	5	3	1	1	5	3	2	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr14:20295797G>C	uc010tkv.1	+	1	190	c.190G>C	c.(190-192)GGC>CGC	p.G64R		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTCTTTCTGGGCAACTTGGC	0.468													92	538					0	0	0	0	C	20295797	C	C	20295797	3	2	259	1	0	0	0	0	1	0	0	0	11131	1232	43	4	192	4	OR4N2	14	20295797	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		20295797	87053743	146	47176											
OR4E2	26686	broad.mit.edu	37	chr14	22134074	22134074	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catgtatcttcatctatactCggccagacaccagcttctcc	9	12	5	15	1	4	1	1	0	3	1	6	1	4	1	3	1	2	2	3	1	3	5			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr14:22134074C>T	uc010tmd.1	+	1	778	c.778C>T	c.(778-780)CGG>TGG	p.R260W		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CATCTATACTCGGCCAGACAC	0.512													20	13					0	0	0	0	T	22134074	T	T	22134074	3	4	259	1	0	0	0	0	1	0	0	0	11114	875	31	1	780	1	OR4E2	14	22134074	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	1838277	22134074	85215466	147	47177											
PCK2	5106	broad.mit.edu	37	chr14	24566219	24566219	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcattcgagattttgtagagCacagtgcccgcctgtgccaa	9	10	11	11	2	0	2	0	0	0	2	1	3	0	2	3	0	3	3	3	0	2	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr14:24566219C>T	uc001wlt.2	+	2	280	c.148C>T	c.(148-150)CAC>TAC	p.H50Y	NRL_uc001wlp.2_5'Flank|NRL_uc001wlq.2_Intron|PCK2_uc001wlr.1_Missense_Mutation_p.H62Y|PCK2_uc001wls.2_Missense_Mutation_p.H50Y|PCK2_uc010tnw.1_Intron|PCK2_uc010ald.2_5'UTR|PCK2_uc010ale.2_5'UTR|PCK2_uc010tnx.1_5'UTR|PCK2_uc001wlu.3_5'UTR	NM_004563	NP_004554	Q16822	PCKGM_HUMAN	mitochondrial phosphoenolpyruvate carboxykinase	50					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0184)		TTTTGTAGAGCACAGTGCCCG	0.587													4	61					0	0	0	0	T	24566219	T	T	24566219	3	4	259	1	0	0	0	0	1	0	0	0	11636	710	25	4	154	4	PCK2	14	24566219	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	2432145	24566219	82783321	148	47178											
LTB4R	1241	broad.mit.edu	37	chr14	24785327	24785327	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccgtcctcgcgtaccgcaCagtagtgccctggaaaacga	10	6	10	15	5	0	0	0	0	0	0	2	2	1	1	4	1	3	3	4	1	4	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr14:24785327C>G	uc001wos.2	+	2	791	c.470C>G	c.(469-471)ACA>AGA	p.T157R	LTB4R_uc010alp.2_Missense_Mutation_p.T157R|LTB4R_uc001wou.2_Missense_Mutation_p.T157R	NM_001143919	NP_001137391	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	157	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding				0				GBM - Glioblastoma multiforme(265;0.018)		GCGTACCGCACAGTAGTGCCC	0.632													43	37					0	0	0	0	G	24785327	G	G	24785327	3	3	259	1	0	0	0	0	1	0	0	0	9121	478	17	4	472	4	LTB4R	14	24785327	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	219108	24785327	82564213	149	47179											
TSHR	7253	broad.mit.edu	37	chr14	81609450	81609450	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccaggatactcataacaacGctcattattacgtcttcttt	11	15	4	11	2	4	0	2	0	2	0	5	1	5	1	1	1	4	1	1	1	5	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr14:81609450G>A	uc001xvd.1	+	10	1204	c.1048G>A	c.(1048-1050)GCT>ACT	p.A350T		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	350	Extracellular (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TCATAACAACGCTCATTATTA	0.448			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						8	61					0	0	0	0	A	81609450	A	A	81609450	3	1	259	1	0	0	0	0	1	0	0	0	16689	1087	38	1	1223	1	TSHR	14	81609450	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	56824123	81609450	25740090	150	47180											
TRIP11	9321	broad.mit.edu	37	chr14	92491671	92491671	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctctttttgttgaagttGatttcggtaacttgtagatt	8	20	8	5	1	1	3	0	2	1	1	2	3	1	3	1	1	2	4	1	1	4	10			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr14:92491671G>A	uc001xzy.2	-	3	1083	c.295C>T	c.(295-297)CAA>TAA	p.Q99*		NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	99	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TGTTGAAGTTGATTTCGGTAA	0.308			T	PDGFRB	AML								6	30					0	0	0	0	A	92491671	A	A	92491671	4	1	259	1	0	0	0	0	0	1	0	0	16622	1299	45	2	5720	2	TRIP11	14	92491671	Nonsense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	10882221	92491671	14857869	151	47181											
AHNAK2	113146	broad.mit.edu	37	chr14	105416847	105416847	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggcagtcaccgccttgtcGgccagggacaggtccccctc	5	8	12	16	2	1	0	1	0	0	0	4	1	2	1	5	4	0	1	5	4	0	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr14:105416847G>A	uc010axc.1	-	7	5061	c.4941C>T	c.(4939-4941)GCC>GCT	p.A1647A	AHNAK2_uc001ypx.2_Silent_p.A1547A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1647						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCGCCTTGTCGGCCAGGGACA	0.607													99	115					0	0	0	0	A	105416847	A	A	105416847	2	1	259	1	0	0	0	0	0	0	0	1	415	1103	39	1		1	AHNAK2	14	105416847	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	12925176	105416847	1932693	152	47182											
FAM98B	283742	broad.mit.edu	37	chr15	38773502	38773502	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcatttaggtaaaaacaGatgatatagcaagaatttat	17	14	7	3	0	1	3	1	1	0	2	1	3	1	3	0	1	2	2	0	1	9	8			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr15:38773502G>T	uc001zkb.1	+	7	774	c.739G>T	c.(739-741)GAT>TAT	p.D247Y	FAM98B_uc001zkc.2_Missense_Mutation_p.D247Y	NM_001042429	NP_001035894	Q52LJ0	FA98B_HUMAN	family with sequence similarity 98, member B	247						tRNA-splicing ligase complex	protein binding			ovary(1)	1		all_cancers(109;3.11e-17)|all_epithelial(112;2.64e-15)|Lung NSC(122;2.11e-11)|all_lung(180;5.61e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;9e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0209)		GGTAAAAACAGATGATATAGC	0.328													7	25					8.12818e-05	8.63832e-05	1	0	T	38773502	T	T	38773502	3	4	259	1	0	0	0	0	1	0	0	0	5689	942	33	2	765	2	FAM98B	15	38773502	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		38773502	63757890	153	47183											
NR2F2	7026	broad.mit.edu	37	chr15	96880846	96880846	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actggccgtatatggcaattCaataaataaataaaataaga	20	10	6	5	1	1	1	1	0	0	1	1	1	1	1	1	2	0	2	1	2	11	7			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr15:96880846C>T	uc010uri.1	+	3	2464	c.1240C>T	c.(1240-1242)CAA>TAA	p.Q414*	NR2F2_uc002btp.2_Nonsense_Mutation_p.Q281*|NR2F2_uc010urj.1_Nonsense_Mutation_p.Q261*|NR2F2_uc010urk.1_Nonsense_Mutation_p.Q261*	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	414	Interaction with ZFPM2 (By similarity).|Important for dimerization.|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			TATGGCAATTCAATAAATAAA	0.378													12	83					0	0	0	0	T	96880846	T	T	96880846	4	4	259	1	0	0	0	0	0	1	0	0	10682	827	29	2	1297	2	NR2F2	15	96880846	Nonsense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	58107344	96880846	5650546	154	47184											
ABCC1	4363	broad.mit.edu	37	chr16	16170205	16170205	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggcacgaacagcatcacCgtgaggaatgccacattcac	12	5	12	12	2	2	1	2	1	0	0	2	3	2	2	2	3	3	2	2	3	2	1	rs150333922	by1000genomes	TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr16:16170205C>T	uc010bvi.2	+	15	2110	c.1935C>T	c.(1933-1935)ACC>ACT	p.T645T	ABCC1_uc010bvj.2_Silent_p.T645T|ABCC1_uc010bvk.2_Silent_p.T645T|ABCC1_uc010bvl.2_Silent_p.T645T|ABCC1_uc010bvm.2_Silent_p.T645T|ABCC1_uc002del.3_Silent_p.T529T	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	645	ABC transporter 1.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ACAGCATCACCGTGAGGAATG	0.483													5	11					0	0	0	0	T	16170205	T	T	16170205	2	4	259	1	0	0	0	0	0	0	0	1	49	639	23	1		1	ABCC1	16	16170205	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08		16170205	74184548	155	47185											
ABCC6	368	broad.mit.edu	37	chr16	16256934	16256934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacaaagggggcctgggttCggaatgcccggaccactgtg	8	6	15	12	2	0	0	0	0	0	0	1	2	0	2	4	5	1	1	4	5	2	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr16:16256934C>T	uc002den.3	-	24	3459	c.3422G>A	c.(3421-3423)CGA>CAA	p.R1141Q	ABCC6_uc010bvo.2_Intron	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	1141	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GGCCTGGGTTCGGAATGCCCG	0.597													18	55					0	0	0	0	T	16256934	T	T	16256934	3	4	259	1	0	0	0	0	1	0	0	0	57	884	31	1	1121	1	ABCC6	16	16256934	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	86729	16256934	74097819	156	47186											
ZNF646	9726	broad.mit.edu	37	chr16	31090886	31090886	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagactggagactttctcTgccctgtctgctcccgctgc	5	11	9	16	1	2	2	0	0	2	2	4	3	3	2	3	1	3	2	3	1	0	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr16:31090886T>G	uc002eap.2	+	2	3530	c.3241T>G	c.(3241-3243)TGC>GGC	p.C1081G		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1081	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						AGACTTTCTCTGCCCTGTCTG	0.627													47	118					0	0	0	0	G	31090886	G	G	31090886	3	3	259	1	0	0	0	0	1	0	0	0	18129	1580	55	5	3243	5	ZNF646	16	31090886	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	14833952	31090886	59263867	157	47187											
ZNF423	23090	broad.mit.edu	37	chr16	49670062	49670062	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcagtgctcaataaactcctCctcgctctgcaggggcatct	8	10	9	14	1	3	0	1	0	2	0	6	0	5	0	2	2	3	5	2	2	3	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr16:49670062C>T	uc002efs.2	-	5	3299	c.3001G>A	c.(3001-3003)GAG>AAG	p.E1001K	ZNF423_uc010vgn.1_Missense_Mutation_p.E884K	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1001					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				ATAAACTCCTCCTCGCTCTGC	0.592													6	11					0	0	0	0	T	49670062	T	T	49670062	3	4	259	1	0	0	0	0	1	0	0	0	17965	864	30	2	873	2	ZNF423	16	49670062	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	18579176	49670062	40684691	158	47188											
CDH8	1006	broad.mit.edu	37	chr16	61687979	61687979	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggttcatttttatgccgccGtagagttacaaacagcacca	11	12	8	10	2	1	1	1	0	0	1	1	1	1	1	3	1	4	4	3	1	4	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr16:61687979G>T	uc002eog.1	-	12	2185	c.1933C>A	c.(1933-1935)CGG>AGG	p.R645R		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	645	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTATGCCGCCGTAGAGTTACA	0.383													13	53					3.03607e-14	3.41222e-14	1	0	T	61687979	T	T	61687979	2	4	259	1	0	0	0	0	0	0	0	1	3131	1144	40	3		3	CDH8	16	61687979	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	12017917	61687979	28666774	159	47189											
CHST4	10164	broad.mit.edu	37	chr16	71571468	71571468	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgtatgaattcgtgggattGgaattcttgccccatcttca	9	15	9	8	1	3	1	1	1	2	0	4	3	3	3	2	2	1	1	2	2	3	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr16:71571468G>T	uc002fan.2	+	2	1069	c.888G>T	c.(886-888)TTG>TTT	p.L296F	CHST4_uc002fao.2_Missense_Mutation_p.L296F	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	296	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						TCGTGGGATTGGAATTCTTGC	0.567											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	36					0.000274275	0.000287876	1	0	T	71571468	T	T	71571468	3	4	259	1	0	0	0	0	1	0	0	0	3421	1339	47	4	890	4	CHST4	16	71571468	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	9883489	71571468	18783285	160	47190											
TP53	7157	broad.mit.edu	37	chr17	7577022	7577022	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtcctgcttgcttacctcGcttagtgctccctgggggca	3	14	11	13	1	0	0	0	0	0	0	3	0	2	0	3	2	4	5	3	2	2	4	rs121913344		TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:7577022G>A	uc002gim.2	-	8	1110	c.916C>T	c.(916-918)CGA>TGA	p.R306*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.R306*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R174*|TP53_uc010cng.1_Nonsense_Mutation_p.R174*|TP53_uc002gii.1_Nonsense_Mutation_p.R174*|TP53_uc010cnh.1_Nonsense_Mutation_p.R306*|TP53_uc010cni.1_Nonsense_Mutation_p.R306*|TP53_uc002gij.2_Nonsense_Mutation_p.R306*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	306	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		R -> Q (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(99)|p.0?(7)|p.?(3)|p.R306R(2)|p.R306fs*39(2)|p.K305fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTACCTCGCTTAGTGCTC	0.562	R306*(MFE296_ENDOMETRIUM)|R306*(HCC1937_BREAST)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	34					0	0	0	0	A	7577022	A	A	7577022	4	1	259	1	0	0	0	0	0	1	0	0	16448	1095	38	1	370	1	TP53	17	7577022	Nonsense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		7577022	73618188	161	47191											
MYH1	4619	broad.mit.edu	37	chr17	10412811	10412811	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaagccaaccttctcgatGagctcgatgcaggcagccag	11	6	11	13	2	1	1	0	1	1	0	3	3	1	1	3	1	6	4	3	1	2	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:10412811G>C	uc002gmo.2	-	15	1672	c.1578C>G	c.(1576-1578)CTC>CTG	p.L526L	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	526	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CCTTCTCGATGAGCTCGATGC	0.443													32	29					0	0	0	0	C	10412811	C	C	10412811	2	2	259	1	0	0	0	0	0	0	0	1	10082	1277	45	2		2	MYH1	17	10412811	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	2835789	10412811	70782399	162	47192											
C17orf48	56985	broad.mit.edu	37	chr17	10608831	10608831	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaatccaaatacggaactGaatagtcctcaaggtgaatt	16	9	7	9	1	1	2	1	2	0	0	3	3	3	3	2	2	2	0	2	2	8	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:10608831G>A	uc002gmt.2	+	2	663	c.588G>A	c.(586-588)CTG>CTA	p.L196L	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA|C17orf48_uc010vvg.1_Silent_p.L196L	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	196							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						ATACGGAACTGAATAGTCCTC	0.383													20	27					0	0	0	0	A	10608831	A	A	10608831	2	1	259	1	0	0	0	0	0	0	0	1	1866	1277	45	2		2	C17orf48	17	10608831	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	196020	10608831	70586379	163	47193											
SLFN5	162394	broad.mit.edu	37	chr17	33592764	33592764	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcacattgtgttggacagtGtctgtcgattttcaggcctg	7	15	11	8	1	3	0	2	0	1	0	4	2	3	1	1	2	0	1	1	2	0	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:33592764G>A	uc002hjf.3	+	5	2650	c.2533G>A	c.(2533-2535)GTC>ATC	p.V845I	SLFN5_uc010wcg.1_3'UTR	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	845					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GTTGGACAGTGTCTGTCGATT	0.488													6	41					0	0	0	0	A	33592764	A	A	33592764	3	1	259	1	0	0	0	0	1	0	0	0	14801	1377	48	4	2547	4	SLFN5	17	33592764	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	22983933	33592764	47602446	164	47194											
JUP	3728	broad.mit.edu	37	chr17	39914709	39914709	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgcggttcatggggtccCgggcgaggatgtgcagtgct	5	9	17	10	3	1	0	1	0	0	0	2	2	2	1	2	5	3	3	2	5	0	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:39914709C>T	uc002hxq.2	-	10	1992	c.1715G>A	c.(1714-1716)CGG>CAG	p.R572Q	JUP_uc010wfs.1_Intron|JUP_uc002hxr.2_Missense_Mutation_p.R572Q|JUP_uc002hxs.2_Missense_Mutation_p.R572Q	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	572					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		CATGGGGTCCCGGGCGAGGAT	0.627													6	41					0	0	0	0	T	39914709	T	T	39914709	3	4	259	1	0	0	0	0	1	0	0	0	8011	652	23	1	542	1	JUP	17	39914709	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	6321945	39914709	41280501	165	47195											
BRCA1	672	broad.mit.edu	37	chr17	41276072	41276072	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttctgcatagcattaatGacattttgtacttcttcaac	11	18	4	8	0	3	1	1	1	2	0	3	1	3	1	0	0	4	3	0	0	4	9	rs80356827		TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:41276072G>A	uc002icq.2	-	2	274	c.42C>T	c.(40-42)GTC>GTT	p.V14V	BRCA1_uc010whp.1_Intron|NBR2_uc002idf.2_5'Flank|NBR2_uc010czb.1_5'Flank|NBR2_uc002idg.2_5'Flank|NBR2_uc002idh.2_5'Flank|BRCA1_uc010whl.1_Silent_p.V14V|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_5'UTR|BRCA1_uc002icu.2_Silent_p.V14V|BRCA1_uc010cyx.2_5'UTR|BRCA1_uc002ict.2_Silent_p.V14V|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc002idc.1_Silent_p.V14V|BRCA1_uc010whr.1_5'UTR|BRCA1_uc002idd.2_Silent_p.V14V|BRCA1_uc010cyy.1_Silent_p.V14V|BRCA1_uc010whs.1_Silent_p.V14V|BRCA1_uc010cyz.2_5'UTR|BRCA1_uc010cza.2_Silent_p.V14V|BRCA1_uc010wht.1_Intron	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	14					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TAGCATTAATGACATTTTGTA	0.318			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			9	35					0	0	0	0	A	41276072	A	A	41276072	2	1	259	1	0	0	0	0	0	0	0	1	1503	1277	45	2		2	BRCA1	17	41276072	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	1361363	41276072	39919138	166	47196											
ITGA2B	3674	broad.mit.edu	37	chr17	42466667	42466667	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggctcacctcccatggctgtCcttgtggaagtccagtgaaa	8	10	11	12	0	1	1	1	1	0	0	4	2	4	2	4	3	0	2	4	3	2	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:42466667C>G	uc002igt.1	-	1	207	c.175G>C	c.(175-177)GAC>CAC	p.D59H		NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	59	Extracellular (Potential).|FG-GAP 1.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	CCATGGCTGTCCTTGTGGAAG	0.587													21	152					0	0	0	0	G	42466667	G	G	42466667	3	3	259	1	0	0	0	0	1	0	0	0	7915	855	30	2	3064	2	ITGA2B	17	42466667	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	1190595	42466667	38728543	167	47197											
MYST2	11143	broad.mit.edu	37	chr17	47895239	47895239	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcaacatgattaaaacaattGcttttggccgctatgagctt	12	13	8	8	1	0	2	0	2	0	0	0	2	0	2	1	1	4	4	1	1	5	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:47895239G>A	uc002ipm.2	+	9	1147	c.1021G>A	c.(1021-1023)GCT>ACT	p.A341T	MYST2_uc002ipl.1_Missense_Mutation_p.A311T|MYST2_uc010wma.1_Missense_Mutation_p.A202T|MYST2_uc010wmb.1_Missense_Mutation_p.A231T|MYST2_uc010wmc.1_Missense_Mutation_p.A172T|MYST2_uc010wmd.1_Missense_Mutation_p.A185T|MYST2_uc010wme.1_Missense_Mutation_p.A155T|MYST2_uc010wmf.1_Missense_Mutation_p.A6T|MYST2_uc010wmg.1_Intron	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	341					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TAAAACAATTGCTTTTGGCCG	0.393													7	34					0	0	0	0	A	47895239	A	A	47895239	3	1	259	1	0	0	0	0	1	0	0	0	10156	1319	46	4	1055	4	MYST2	17	47895239	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	5428572	47895239	33299971	168	47198											
MTMR4	9110	broad.mit.edu	37	chr17	56581705	56581705	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaacaggcaggggaactgctTaagcaactgatgaacagaat	17	6	11	7	0	0	3	0	2	0	1	0	4	0	4	0	3	6	3	0	3	6	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:56581705T>C	uc002iwj.2	-	13	1554	c.1444A>G	c.(1444-1446)AAG>GAG	p.K482E		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	482	Myotubularin phosphatase.					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGAACTGCTTAAGCAACTGA	0.517													9	70					0	0	0	0	C	56581705	C	C	56581705	3	2	259	1	0	0	0	0	1	0	0	0	9999	1763	61	5	2171	5	MTMR4	17	56581705	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	8686466	56581705	24613505	169	47199											
FDXR	2232	broad.mit.edu	37	chr17	72860034	72860034	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcacctggcacatccataacCcggccctccacattggggat	9	8	8	16	1	1	0	1	0	0	0	3	1	3	1	5	4	1	1	5	4	1	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:72860034C>A	uc002jly.2	-	10	1245	c.1158G>T	c.(1156-1158)CGG>CGT	p.R386R	FDXR_uc010wri.1_Silent_p.R334R|FDXR_uc010wrj.1_Silent_p.R384R|FDXR_uc002jlw.2_Silent_p.R143R|FDXR_uc002jlx.2_Silent_p.R392R|FDXR_uc002jmc.2_Silent_p.R358R|FDXR_uc010wrk.1_Silent_p.R417R|FDXR_uc010wrl.1_Silent_p.R429R|FDXR_uc002jma.2_Silent_p.R387R|FDXR_uc010wrm.1_Silent_p.R346R|FDXR_uc002jlz.2_Silent_p.R378R|FDXR_uc002jmb.2_Intron	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	386					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					CATCCATAACCCGGCCCTCCA	0.577													53	136					1.95512e-22	2.22691e-22	1	0	A	72860034	A	A	72860034	2	1	259	1	0	0	0	0	0	0	0	1	5839	610	22	4		4	FDXR	17	72860034	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	16278329	72860034	8335176	170	47200											
OTOP2	92736	broad.mit.edu	37	chr17	72923807	72923807	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caacctggccatctggatggCggccgtggtggatgaatctg	7	9	15	10	2	2	1	0	1	2	0	2	3	2	3	3	6	1	0	3	6	2	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:72923807C>A	uc010wrp.1	+	6	646	c.557C>A	c.(556-558)GCG>GAG	p.A186E	OTOP2_uc002jmf.1_3'UTR	NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	186						integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					ATCTGGATGGCGGCCGTGGTG	0.577													10	31					1.58986e-06	1.72575e-06	1	0	A	72923807	A	A	72923807	3	1	259	1	0	0	0	0	1	0	0	0	11360	768	27	3	571	3	OTOP2	17	72923807	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	63773	72923807	8271403	171	47201											
UBE2O	63893	broad.mit.edu	37	chr17	74392380	74392380	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctctacgtcgggcactgcttCcatcttctcctcctctacaa	6	13	5	17	2	4	0	0	0	4	0	8	0	6	0	3	1	3	2	3	1	3	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr17:74392380C>A	uc002jrm.3	-	14	2703	c.2638G>T	c.(2638-2640)GAA>TAA	p.E880*	UBE2O_uc002jrn.3_Nonsense_Mutation_p.E880*|UBE2O_uc002jrl.3_Nonsense_Mutation_p.E484*	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	880	Potential.						ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						GGCACTGCTTCCATCTTCTCC	0.567													59	136					4.96364e-44	5.73075e-44	1	0	A	74392380	A	A	74392380	4	1	259	1	0	0	0	0	0	1	0	0	16936	864	30	2	1260	2	UBE2O	17	74392380	Nonsense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	1468573	74392380	6802830	172	47202											
ZNF521	25925	broad.mit.edu	37	chr18	22804524	22804524	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcactcagattctcattctGgcccaagcctggtctattcg	7	12	9	13	1	4	1	2	0	3	1	6	1	4	1	2	3	1	1	2	3	2	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr18:22804524G>A	uc002kvk.2	-	4	3605	c.3358C>T	c.(3358-3360)CAG>TAG	p.Q1120*	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Nonsense_Mutation_p.Q1120*|ZNF521_uc002kvl.2_Nonsense_Mutation_p.Q900*	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1120					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TTCTCATTCTGGCCCAAGCCT	0.552			T	PAX5	ALL								4	26					0	0	0	0	A	22804524	A	A	22804524	4	1	259	1	0	0	0	0	0	1	0	0	18032	1357	47	4	597	4	ZNF521	18	22804524	Nonsense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08		22804524	55272724	173	47203											
LMNB2	84823	broad.mit.edu	37	chr19	2444428	2444428	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgacctcgtccaactctgcCctcagcttcccaatctctat	7	13	4	17	1	3	1	1	1	2	0	7	1	5	1	4	0	3	1	4	0	3	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:2444428C>G	uc002lvy.2	-	2	402	c.315G>C	c.(313-315)AGG>AGC	p.R105S	LMNB2_uc002lwa.1_Missense_Mutation_p.R125S	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	105	Rod.|Coil 1B.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAACTCTGCCCTCAGCTTCC	0.652													5	21					0	0	0	0	G	2444428	G	G	2444428	3	3	259	1	0	0	0	0	1	0	0	0	8892	622	22	4	1531	4	LMNB2	19	2444428	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08		2444428	56684555	174	47204											
ZNRF4	148066	broad.mit.edu	37	chr19	5455848	5455848	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcggtggactttgcggatCtgccggcgctgttcggcgtc	2	11	16	12	6	1	0	0	0	1	0	4	2	1	2	1	5	2	3	1	5	0	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:5455848C>G	uc002mca.3	+	1	423	c.346C>G	c.(346-348)CTG>GTG	p.L116V		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	116	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CTTTGCGGATCTGCCGGCGCT	0.672													21	70					0	0	0	0	G	5455848	G	G	5455848	3	3	259	1	0	0	0	0	1	0	0	0	18281	912	32	2	348	2	ZNRF4	19	5455848	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	3011420	5455848	53673135	175	47205											
FCER2	2208	broad.mit.edu	37	chr19	7754154	7754154	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatcaggtcccatggactcCgcggaaccttcgctggctgg	7	8	13	13	3	1	0	1	0	0	0	4	3	3	2	3	5	1	2	3	5	2	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:7754154C>A	uc002mhn.2	-	11	1075	c.891G>T	c.(889-891)GCG>GCT	p.A297A	FCER2_uc010xjs.1_Silent_p.A219A|FCER2_uc010xjt.1_Silent_p.A219A|FCER2_uc002mhm.2_Silent_p.A297A	NM_002002	NP_001993	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor	297	Extracellular (Potential).				positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding				0						CCATGGACTCCGCGGAACCTT	0.677													7	21					0.00198382	0.00205669	1	0	A	7754154	A	A	7754154	2	1	259	1	0	0	0	0	0	0	0	1	5808	639	23	3		3	FCER2	19	7754154	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	2298306	7754154	51374829	176	47206											
MUC16	94025	broad.mit.edu	37	chr19	9006359	9006359	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcacctgagcaaggtcagtCtgcagccagaatacagaggg	12	6	12	11	0	3	3	2	1	1	2	3	3	3	3	2	2	4	2	2	2	3	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:9006359C>G	uc002mkp.2	-	45	39863	c.39659G>C	c.(39658-39660)AGA>ACA	p.R13220T	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.R37T|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13222	SEA 8.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAAGGTCAGTCTGCAGCCAGA	0.512													16	56					0	0	0	0	G	9006359	G	G	9006359	3	3	259	1	0	0	0	0	1	0	0	0	10026	913	32	2	4024	2	MUC16	19	9006359	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	1252205	9006359	50122624	177	47207											
MUC16	94025	broad.mit.edu	37	chr19	9065156	9065156	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacacctcagtagtcttcacTtggcctggtgtgagaagtga	10	11	11	9	0	3	2	2	2	1	1	3	3	3	2	2	2	1	1	2	2	3	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:9065156T>C	uc002mkp.2	-	3	22494	c.22290A>G	c.(22288-22290)CAA>CAG	p.Q7430Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7432	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAGTCTTCACTTGGCCTGGTG	0.488													13	31					0	0	0	0	C	9065156	C	C	9065156	2	2	259	1	0	0	0	0	0	0	0	1	10026	1606	56	5		5	MUC16	19	9065156	Silent	SNP	T	TCGA-CV-7424-01A-11D-2078-08	58797	9065156	50063827	178	47208											
ZNF627	199692	broad.mit.edu	37	chr19	11727528	11727528	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtcatattccagagagactCtgtgaaagtaaagaaggtgg	15	9	12	5	0	2	4	1	1	1	3	3	5	3	4	1	2	0	1	1	2	5	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:11727528C>T	uc002msk.2	+	4	418	c.210C>T	c.(208-210)CTC>CTT	p.L70L	ZNF627_uc010dyf.2_5'UTR	NM_145295	NP_660338	Q7L945	ZN627_HUMAN	zinc finger protein 627	70	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CAGAGAGACTCTGTGAAAGTA	0.313													6	30					0	0	0	0	T	11727528	T	T	11727528	2	4	259	1	0	0	0	0	0	0	0	1	18118	900	32	2		2	ZNF627	19	11727528	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	2662372	11727528	47401455	179	47209											
PKN1	5585	broad.mit.edu	37	chr19	14582517	14582517	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcccccacactgagccCgccccgcgacgcgcggcccc	5	1	13	22	6	0	1	0	1	0	0	0	3	0	2	7	3	1	0	7	3	0	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:14582517C>T	uc002myp.2	+	22	2918	c.2750C>T	c.(2749-2751)CCG>CTG	p.P917L	PKN1_uc002myq.2_Missense_Mutation_p.P923L|PKN1_uc002myr.2_Missense_Mutation_p.P257L	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	917	AGC-kinase C-terminal.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8						ACACTGAGCCCGCCCCGCGAC	0.652													3	16					0	0	0	0	T	14582517	T	T	14582517	3	4	259	1	0	0	0	0	1	0	0	0	12034	652	23	1	2879	1	PKN1	19	14582517	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	2854989	14582517	44546466	180	47210											
EPS15L1	58513	broad.mit.edu	37	chr19	16528779	16528779	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgggccgggcgtgcctctctCcgaaggcgggaccatgtccg	4	6	16	15	6	1	0	0	0	1	0	4	2	3	1	5	4	1	0	5	4	1	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:16528779C>T	uc002ndz.1	-	11	1093	c.1087G>A	c.(1087-1089)GAG>AAG	p.E363K	EPS15L1_uc002ndx.2_Missense_Mutation_p.E363K|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.E253K|EPS15L1_uc010xpf.1_Missense_Mutation_p.E266K|EPS15L1_uc002nea.1_Missense_Mutation_p.E363K|EPS15L1_uc010eah.1_Missense_Mutation_p.E363K|EPS15L1_uc002neb.1_Missense_Mutation_p.E209K|EPS15L1_uc002nec.1_Missense_Mutation_p.E363K	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	363	EH 3.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						GTGCCTCTCTCCGAAGGCGGG	0.592											OREG0025334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	50					0	0	0	0	T	16528779	T	T	16528779	3	4	259	1	0	0	0	0	1	0	0	0	5217	864	30	2	1559	2	EPS15L1	19	16528779	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	1946262	16528779	42600204	181	47211											
ZNF208	7757	broad.mit.edu	37	chr19	22171649	22171649	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tataaattctgctgtgcagtGtccaggcattgccactcctc	8	13	8	12	0	1	0	0	0	1	0	4	0	3	0	3	1	3	3	3	1	3	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:22171649G>T	uc002nqp.2	-	2	215	c.66C>A	c.(64-66)GAC>GAA	p.D22E	ZNF208_uc002nqo.1_Missense_Mutation_p.D22E|ZNF208_uc002nqq.2_RNA	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GCTGTGCAGTGTCCAGGCATT	0.398													26	135					6.32553e-13	7.07791e-13	1	0	T	22171649	T	T	22171649	3	4	259	1	0	0	0	0	1	0	0	0	17833	1368	48	4	3788	4	ZNF208	19	22171649	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	5642870	22171649	36957334	182	47212											
ZNF681	148213	broad.mit.edu	37	chr19	23938239	23938239	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcctcacccaagaagaccaGgtttctgtagttctctaaca	12	11	6	12	0	3	2	1	0	2	2	5	2	4	2	3	1	1	3	3	1	4	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:23938239G>T	uc002nrk.3	-	2	260	c.118C>A	c.(118-120)CTG>ATG	p.L40M	ZNF681_uc002nrl.3_Intron|ZNF681_uc002nrj.3_Intron|ZNF681_uc002nrm.1_5'Flank	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	40	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				AAGAAGACCAGGTTTCTGTAG	0.353													16	111					0.000175454	0.000185689	1	0	T	23938239	T	T	23938239	3	4	259	1	0	0	0	0	1	0	0	0	18155	991	35	4	1831	4	ZNF681	19	23938239	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	1766590	23938239	35190744	183	47213											
ZNF527	84503	broad.mit.edu	37	chr19	37880679	37880679	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agactacaccagagaattcaCgctggagaaaaaccttataa	18	7	7	9	1	1	3	1	0	0	3	1	5	1	3	2	1	2	1	2	1	6	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:37880679C>T	uc010efk.1	+	5	1839	c.1728C>T	c.(1726-1728)CAC>CAT	p.H576H	ZNF527_uc002ogf.3_Silent_p.H544H|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	576	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGAGAATTCACGCTGGAGAAA	0.388													16	50					0	0	0	0	T	37880679	T	T	37880679	2	4	259	1	0	0	0	0	0	0	0	1	18035	535	19	1		1	ZNF527	19	37880679	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	13942440	37880679	21248304	184	47214											
GPR77	27202	broad.mit.edu	37	chr19	47844440	47844440	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcctgctcctggcagctctCagtgccgacctctgcttcct	3	12	9	17	1	2	0	1	0	2	0	6	1	5	0	5	1	4	4	5	1	0	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:47844440C>G	uc010ela.1	+	2	602	c.384C>G	c.(382-384)CTC>CTG	p.L128L	GPR77_uc002pgk.1_Silent_p.L128L	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	128	Helical; Name=3; (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		TGGCAGCTCTCAGTGCCGACC	0.682													16	92					0	0	0	0	G	47844440	G	G	47844440	2	3	259	1	0	0	0	0	0	0	0	1	6747	813	29	2		2	GPR77	19	47844440	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	9963761	47844440	11284543	185	47215											
TPRX1	284355	broad.mit.edu	37	chr19	48305438	48305438	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccttggagtctgcctgggCctgggatctgggctgggctg	2	10	19	10	0	2	0	0	0	2	0	2	2	2	2	3	6	1	2	3	6	0	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:48305438C>T	uc002php.1	-	2	901	c.830G>A	c.(829-831)GGC>GAC	p.G277D		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox	277	Gly-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		TCTGCCTGGGCCTGGGATCTG	0.383													8	8					0	0	0	0	T	48305438	T	T	48305438	3	4	259	1	0	0	0	0	1	0	0	0	16489	739	26	4	409	4	TPRX1	19	48305438	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	460998	48305438	10823545	186	47216											
TSKS	60385	broad.mit.edu	37	chr19	50266465	50266465	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccccggcctcatggatctCtttggactgccagatcgtct	5	12	10	14	2	3	1	1	0	2	1	6	3	4	3	4	3	1	0	4	3	0	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:50266465C>G	uc002ppm.2	-	1	51	c.40G>C	c.(40-42)GAG>CAG	p.E14Q		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	14							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		TCATGGATCTCTTTGGACTGC	0.657													31	48					0	0	0	0	G	50266465	G	G	50266465	3	3	259	1	0	0	0	0	1	0	0	0	16693	922	32	2	1782	2	TSKS	19	50266465	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	1961027	50266465	8862518	187	47217											
ZNF616	90317	broad.mit.edu	37	chr19	52619089	52619089	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatgcttactgtacaccttgCcacatttattgcatttgtaa	11	16	5	9	0	0	0	0	0	0	0	0	0	0	0	2	0	5	4	2	0	5	8			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:52619089C>A	uc002pym.2	-	4	1611	c.1328G>T	c.(1327-1329)GGC>GTC	p.G443V	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	443	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		GTACACCTTGCCACATTTATT	0.388													9	82					5.4927e-09	6.0396e-09	1	0	A	52619089	A	A	52619089	3	1	259	1	0	0	0	0	1	0	0	0	18108	739	26	4	1021	4	ZNF616	19	52619089	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	2352624	52619089	6509894	188	47218											
ZNF610	162963	broad.mit.edu	37	chr19	52869650	52869650	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcagagaagtcacacggCggaaaaaccttacaaatgta	17	7	8	9	2	3	1	3	0	0	1	3	3	3	2	1	2	2	1	1	2	6	2	rs149251185		TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:52869650C>T	uc002pyx.3	+	6	1425	c.1019C>T	c.(1018-1020)GCG>GTG	p.A340V	ZNF610_uc002pyy.3_Missense_Mutation_p.A340V|ZNF610_uc002pyz.3_Missense_Mutation_p.A297V|ZNF610_uc002pza.2_Missense_Mutation_p.A340V	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		AGTCACACGGCGGAAAAACCT	0.393													6	54					0	0	0	0	T	52869650	T	T	52869650	3	4	259	1	0	0	0	0	1	0	0	0	18103	768	27	1	1033	1	ZNF610	19	52869650	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	250561	52869650	6259333	189	47219											
ZNF808	388558	broad.mit.edu	37	chr19	53058461	53058461	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggtgagaaaccttacaaGtgtaacgactgtggcaatac	14	9	11	7	1	0	1	0	1	0	1	0	3	0	1	1	2	4	2	1	2	6	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:53058461G>A	uc010epq.1	+	5	2469	c.2292G>A	c.(2290-2292)AAG>AAA	p.K764K	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	764	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		AACCTTACAAGTGTAACGACT	0.443													12	141					0	0	0	0	A	53058461	A	A	53058461	2	1	259	1	0	0	0	0	0	0	0	1	18240	1020	36	4		4	ZNF808	19	53058461	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	188811	53058461	6070522	190	47220											
ZNF320	162967	broad.mit.edu	37	chr19	53367249	53367249	+	RNA	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaaaagccaagatacacaagGacagattcttcatgtctgga	16	8	9	8	0	3	2	1	0	2	2	3	5	3	4	1	2	2	0	1	2	5	3	rs1469449	by1000genomes	TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-11A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	8e0eb2fd-3232-45be-bd34-9a00cbf00836	g.chr19:53367249G>A	uc010eqh.1	-	3		c.428C>T			ZNF320_uc010eqi.1_RNA			A2RRD8	ZN320_HUMAN	Homo sapiens full length insert cDNA clone ZD42C02.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		GATACACAAGGACAGATTCTT	0.393													3	27					0	0	0	0	A	53367249	A	A	53367249	1	1	259	0	1	0	0	0	0	0	0	0	17906	1189	41	2		2	ZNF320	19	53367249	RNA	SNP	G	TCGA-CV-7424-01A-11D-2078-08	308788	53367249	5761734	191	47221											
ZNF835	90485	broad.mit.edu	37	chr19	57175082	57175082	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtcccgaactgtctgcatgCgtcctctggtgtcggatgag	5	11	13	12	4	2	1	0	1	2	0	5	3	4	2	2	2	3	1	2	2	1	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr19:57175082C>T	uc010ygo.1	-	2	1551	c.1551G>A	c.(1549-1551)ACG>ACA	p.T517T	ZNF835_uc010ygn.1_Silent_p.T495T	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						TGTCTGCATGCGTCCTCTGGT	0.637													51	116					0	0	0	0	T	57175082	T	T	57175082	2	4	259	1	0	0	0	0	0	0	0	1	18253	755	27	1		1	ZNF835	19	57175082	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	3807833	57175082	1953901	192	47222											
FLRT3	23767	broad.mit.edu	37	chr20	14306666	14306666	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcagtttcagtctcaataCaaacaggagtttcatcaaat	14	12	7	8	0	4	0	4	0	1	0	5	1	4	1	0	1	3	3	0	1	4	3			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr20:14306666C>G	uc002wov.1	-	3	1954	c.1487G>C	c.(1486-1488)TGT>TCT	p.C496S	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.C496S	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	496	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		AGTCTCAATACAAACAGGAGT	0.448													10	77					0	0	0	0	G	14306666	G	G	14306666	3	3	259	1	0	0	0	0	1	0	0	0	5972	478	17	4	466	4	FLRT3	20	14306666	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08		14306666	48718854	193	47223											
DNMT3B	1789	broad.mit.edu	37	chr20	31374312	31374312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctctcttgcttctaggtccGaactcgaaataacaacagtg	11	11	7	12	2	2	0	0	0	2	0	5	2	3	0	2	1	4	1	2	1	5	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr20:31374312G>A	uc002wyc.2	+	5	632	c.311G>A	c.(310-312)CGA>CAA	p.R104Q	DNMT3B_uc010ztx.1_Intron|DNMT3B_uc010zty.1_Intron|DNMT3B_uc002wyd.2_Missense_Mutation_p.R104Q|DNMT3B_uc002wye.2_Missense_Mutation_p.R104Q|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Intron|DNMT3B_uc010zua.1_Intron|DNMT3B_uc002wyf.2_Missense_Mutation_p.R116Q	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	104	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						TTCTAGGTCCGAACTCGAAAT	0.627													3	30					0	0	0	0	A	31374312	A	A	31374312	3	1	259	1	0	0	0	0	1	0	0	0	4699	1058	37	1	365	1	DNMT3B	20	31374312	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	17067646	31374312	31651208	194	47224											
C20orf71	128861	broad.mit.edu	37	chr20	31811751	31811751	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagcggcaggaaacaccagCagcagcaagagagcaggtga	15	2	14	10	1	1	2	1	1	0	1	1	4	1	3	1	3	6	5	1	3	2	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr20:31811751C>A	uc002wyr.2	+	2	470	c.262C>A	c.(262-264)CAG>AAG	p.Q88K	C20orf71_uc002wys.2_Missense_Mutation_p.Q88K	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium	88	Poly-Gln.					extracellular region	lipid binding			ovary(1)|skin(1)	2						GAAACACCAGCAGCAGCAAGA	0.567													20	33					1.2644e-06	1.37836e-06	1	0	A	31811751	A	A	31811751	3	1	259	1	0	0	0	0	1	0	0	0	2127	711	25	4	268	4	C20orf71	20	31811751	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	437439	31811751	31213769	195	47225											
RALGAPB	57148	broad.mit.edu	37	chr20	37150265	37150265	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actatgaagcaggaagagctGaggcttgtgggacactgtgt	11	9	15	6	0	0	3	0	2	0	1	0	5	0	5	0	3	2	3	0	3	3	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr20:37150265G>C	uc002xiw.2	+	10	1800	c.1543G>C	c.(1543-1545)GAG>CAG	p.E515Q	RALGAPB_uc010zvz.1_Intron|RALGAPB_uc002xix.2_Missense_Mutation_p.E515Q|RALGAPB_uc002xiy.1_Missense_Mutation_p.E515Q|RALGAPB_uc002xiz.2_Missense_Mutation_p.E293Q|RALGAPB_uc002xja.1_Missense_Mutation_p.E242Q	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	515					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						AGGAAGAGCTGAGGCTTGTGG	0.413													16	98					0	0	0	0	C	37150265	C	C	37150265	3	2	259	1	0	0	0	0	1	0	0	0	13080	1291	45	2	1577	2	RALGAPB	20	37150265	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	5338514	37150265	25875255	196	47226											
ZNF334	55713	broad.mit.edu	37	chr20	45130768	45130768	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acattcactacattcataggGtttttcccctgtgtgaattc	9	16	6	10	0	2	1	2	1	0	0	4	1	3	1	2	1	1	1	2	1	3	7	rs141823361	byFrequency	TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr20:45130768G>A	uc002xsc.2	-	5	1394	c.1210C>T	c.(1210-1212)CCC>TCC	p.P404S	ZNF334_uc002xsa.2_Missense_Mutation_p.P427S|ZNF334_uc002xsb.2_Missense_Mutation_p.P366S|ZNF334_uc002xsd.2_Missense_Mutation_p.P366S|ZNF334_uc010ghl.2_Missense_Mutation_p.P403S	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				CATTCATAGGGTTTTTCCCCT	0.438													28	128					0	0	0	0	A	45130768	A	A	45130768	3	1	259	1	0	0	0	0	1	0	0	0	17918	1261	44	4	836	4	ZNF334	20	45130768	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	7980503	45130768	17894752	197	47227											
LAMA5	3911	broad.mit.edu	37	chr20	60885489	60885489	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acagacctaaagtgataactCccccgctgcctgggaagaac	13	6	9	13	1	0	3	0	1	0	2	1	4	1	4	4	1	3	1	4	1	5	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr20:60885489C>G	uc002ycq.2	-	76	10653	c.10586G>C	c.(10585-10587)GGA>GCA	p.G3529A		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3529	Laminin G-like 5.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTGATAACTCCCCCGCTGCC	0.692													4	36					0	0	0	0	G	60885489	G	G	60885489	3	3	259	1	0	0	0	0	1	0	0	0	8649	855	30	2	521	2	LAMA5	20	60885489	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	15754721	60885489	2140031	198	47228											
IGSF5	150084	broad.mit.edu	37	chr21	41142937	41142937	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctcacactggacccggctCccggatatttcctgggagct	6	9	10	16	2	1	0	1	0	0	0	3	3	3	3	4	4	1	2	4	4	1	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr21:41142937C>T	uc002yyo.2	+	4	616	c.513C>T	c.(511-513)CTC>CTT	p.L171L		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	171	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				GGACCCGGCTCCCGGATATTT	0.502													21	32					0	0	0	0	T	41142937	T	T	41142937	2	4	259	1	0	0	0	0	0	0	0	1	7641	842	30	2		2	IGSF5	21	41142937	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08		41142937	6986958	199	47229											
C21orf33	8209	broad.mit.edu	37	chr21	45563136	45563136	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccaaggtgctcagaggcgtcGaggtgactgtgggccacgag	8	6	17	10	3	1	2	1	1	0	1	2	4	1	2	2	4	1	1	2	4	1	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr21:45563136G>C	uc002zec.3	+	6	657	c.571G>C	c.(571-573)GAG>CAG	p.E191Q	C21orf33_uc002zed.3_Missense_Mutation_p.E160Q	NM_004649	NP_004640	P30042	ES1_HUMAN	es1 protein isoform Ia precursor	191						mitochondrion				ovary(1)	1				STAD - Stomach adenocarcinoma(101;0.168)|Colorectal(79;0.191)		CAGAGGCGTCGAGGTGACTGT	0.622													11	17					0	0	0	0	C	45563136	C	C	45563136	3	2	259	1	0	0	0	0	1	0	0	0	2135	1059	37	3	593	3	C21orf33	21	45563136	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	4420199	45563136	2566759	200	47230											
KLHL22	84861	broad.mit.edu	37	chr22	20843396	20843396	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagcagccctcggagcagagCctgggagtgctgtgcgctgc	6	6	16	13	2	0	1	0	0	0	1	1	3	0	3	2	2	7	4	2	2	0	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr22:20843396C>T	uc002zsl.1	-	2	212	c.103G>A	c.(103-105)GCT>ACT	p.A35T	KLHL22_uc011ahr.1_5'UTR|KLHL22_uc002zsm.1_Missense_Mutation_p.A35T	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	35					cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CGGAGCAGAGCCTGGGAGTGC	0.627													13	41					0	0	0	0	T	20843396	T	T	20843396	3	4	259	1	0	0	0	0	1	0	0	0	8416	739	26	4	1825	4	KLHL22	22	20843396	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08		20843396	30461170	201	47231											
PATZ1	23598	broad.mit.edu	37	chr22	31740836	31740836	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcactggatgccacactgggGaatggggaagtcagcagttg	10	7	16	8	0	1	0	1	0	0	0	1	3	1	3	1	5	2	3	1	5	2	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr22:31740836G>A	uc003akq.2	-	1	1414	c.753C>T	c.(751-753)TTC>TTT	p.F251F	PATZ1_uc003akp.2_Silent_p.F251F|PATZ1_uc003akr.2_Silent_p.F251F|PATZ1_uc003aks.2_Silent_p.F251F|uc003akt.2_5'Flank	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	251					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						CCACACTGGGGAATGGGGAAG	0.647													3	26					0	0	0	0	A	31740836	A	A	31740836	2	1	259	1	0	0	0	0	0	0	0	1	11530	1165	41	2		2	PATZ1	22	31740836	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08	10897440	31740836	19563730	202	47232											
CELSR1	9620	broad.mit.edu	37	chr22	46859643	46859643	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgcaggtgtagccgccctCgcggctgcggcagcggccgt	3	6	16	16	7	0	0	0	0	0	0	2	0	0	0	3	4	3	4	3	4	1	1			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chr22:46859643C>T	uc003bhw.1	-	2	4144	c.4144G>A	c.(4144-4146)GAG>AAG	p.E1382K		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1382	Extracellular (Potential).|EGF-like 2; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TAGCCGCCCTCGCGGCTGCGG	0.687													3	3					0	0	0	0	T	46859643	T	T	46859643	3	4	259	1	0	0	0	0	1	0	0	0	3236	893	31	1	5036	1	CELSR1	22	46859643	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	15118807	46859643	4444923	203	47233											
DCAF8L2	347442	broad.mit.edu	37	chrX	27766113	27766113	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagaaaatgataagaaagtGggactgtatacaattactgt	18	10	10	3	0	0	3	0	1	0	2	0	5	0	4	0	1	2	1	0	1	8	4			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chrX:27766113G>T	uc011mjy.1	+	1	1188	c.1101G>T	c.(1099-1101)GTG>GTT	p.V367V		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						ATAAGAAAGTGGGACTGTATA	0.418													10	14					2.17888e-05	2.33517e-05	1	0	T	27766113	T	T	27766113	2	4	259	1	0	0	0	0	0	0	0	1	4295	1335	47	4		4	DCAF8L2	23	27766113	Silent	SNP	G	TCGA-CV-7424-01A-11D-2078-08		27766113	127504447	204	47234											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29973400	29973400	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcagtgaactgagaggaatTatgaactaccaggaggtgga	14	8	14	5	0	0	3	0	3	0	1	0	7	0	6	1	4	4	1	1	4	5	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chrX:29973400T>G	uc004dby.2	+	11	2062	c.1554T>G	c.(1552-1554)ATT>ATG	p.I518M		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	518	Cytoplasmic (Potential).|TIR.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TGAGAGGAATTATGAACTACC	0.448													27	9					0	0	0	0	G	29973400	G	G	29973400	3	3	259	1	0	0	0	0	1	0	0	0	7700	1742	61	5	1592	5	IL1RAPL1	23	29973400	Missense_Mutation	SNP	T	TCGA-CV-7424-01A-11D-2078-08	2207287	29973400	125297160	205	47235											
DMD	1756	broad.mit.edu	37	chrX	32305682	32305682	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acattttgttaactttttccCattggaaatcaagctgggag	11	15	8	7	0	1	0	1	0	0	0	2	2	2	2	1	2	2	2	1	2	3	6			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chrX:32305682C>T	uc004dda.1	-	43	6498	c.6254G>A	c.(6253-6255)TGG>TAG	p.W2085*	DMD_uc004dcw.2_Nonsense_Mutation_p.W741*|DMD_uc004dcx.2_Nonsense_Mutation_p.W744*|DMD_uc004dcz.2_Nonsense_Mutation_p.W1962*|DMD_uc004dcy.1_Nonsense_Mutation_p.W2081*|DMD_uc004ddb.1_Nonsense_Mutation_p.W2077*|DMD_uc010ngo.1_Intron|DMD_uc010ngn.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2085	Spectrin 14.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AACTTTTTCCCATTGGAAATC	0.398													28	19					0	0	0	0	T	32305682	T	T	32305682	4	4	259	1	0	0	0	0	0	1	0	0	4602	595	21	4	5099	4	DMD	23	32305682	Nonsense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	2332282	32305682	122964878	206	47236											
UPRT	139596	broad.mit.edu	37	chrX	74494189	74494189	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagctgcgacctggcgatCtgatcctggaccacgcaggg	8	6	14	13	3	1	1	0	1	1	0	2	4	2	2	3	3	3	3	3	3	0	0			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chrX:74494189C>T	uc004ecb.1	+	1	229	c.100C>T	c.(100-102)CTG>TTG	p.L34L	UPRT_uc010nlu.1_Silent_p.L34L|UPRT_uc004ecc.1_RNA|UPRT_uc004ecd.1_Silent_p.L34L|UPRT_uc004ece.1_5'Flank	NM_145052	NP_659489	Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog	34					nucleoside metabolic process	cytoplasm|nucleus					0						ACCTGGCGATCTGATCCTGGA	0.612													4	16					0	0	0	0	T	74494189	T	T	74494189	2	4	259	1	0	0	0	0	0	0	0	1	17082	912	32	2		2	UPRT	23	74494189	Silent	SNP	C	TCGA-CV-7424-01A-11D-2078-08	42188507	74494189	80776371	207	47237											
MAGEC1	9947	broad.mit.edu	37	chrX	140994922	140994922	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaggactccctgtctcctCactactttcctcagagccct	6	11	8	16	0	3	1	2	0	1	1	6	3	5	3	4	2	2	0	4	2	1	2			TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chrX:140994922C>T	uc004fbt.2	+	4	2018	c.1732C>T	c.(1732-1734)CAC>TAC	p.H578Y	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	578							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGTCTCCTCACTACTTTCC	0.582										HNSCC(15;0.026)			118	109					0	0	0	0	T	140994922	T	T	140994922	3	4	259	1	0	0	0	0	1	0	0	0	9233	826	29	2	1738	2	MAGEC1	23	140994922	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	66500733	140994922	14275638	208	47238											
CXorf40A	91966	broad.mit.edu	37	chrX	148627337	148627337	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgggaaggcgatgcctggcGggagctgctggtggagagac	7	6	20	8	2	0	1	0	0	0	1	0	6	0	4	1	6	3	2	1	6	1	0	rs149793182	byFrequency	TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chrX:148627337G>A	uc004fdb.2	+	4	433	c.161G>A	c.(160-162)CGG>CAG	p.R54Q	CXorf40A_uc011mxm.1_Missense_Mutation_p.R54Q|CXorf40A_uc011mxn.1_Missense_Mutation_p.R54Q|CXorf40A_uc004fdd.2_Missense_Mutation_p.R54Q|CXorf40A_uc004fde.1_Missense_Mutation_p.R54Q|CXorf40A_uc011mxo.1_Silent_p.A143A|CXorf40A_uc004fdg.2_Missense_Mutation_p.R54Q|CXorf40A_uc004fdf.2_Missense_Mutation_p.R54Q|CXorf40A_uc004fdh.2_Missense_Mutation_p.R54Q|CXorf40A_uc010nsy.2_Missense_Mutation_p.R54Q|CXorf40A_uc004fdi.2_Missense_Mutation_p.R71Q	NM_178124	NP_835225	Q8TE69	CX04A_HUMAN	chromosome X open reading frame 40	54							protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GATGCCTGGCGGGAGCTGCTG	0.592													12	17					0	0	0	0	A	148627337	A	A	148627337	3	1	259	1	0	0	0	0	1	0	0	0	4125	1116	39	1	163	1	CXorf40A	23	148627337	Missense_Mutation	SNP	G	TCGA-CV-7424-01A-11D-2078-08	7632415	148627337	6643223	209	47239											
G6PD	2539	broad.mit.edu	37	chrX	153760877	153760877	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catcttggtgtacacggcctCgttgggctgcacgcggatca	6	10	13	12	4	2	0	1	0	1	0	3	1	2	1	1	4	2	4	1	4	1	3	rs137852325		TCGA-CV-7424-01A-11D-2078-08	TCGA-CV-7424-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	76d5fc22-fd06-43f6-94a8-943a09db5fd6	9e9c86a0-0085-45e5-87e2-5c729901b55c	g.chrX:153760877C>T	uc004fly.1	-	10	1305	c.1192G>A	c.(1192-1194)GAG>AAG	p.E398K	G6PD_uc004flx.1_Missense_Mutation_p.E428K	NM_001042351	NP_001035810	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase isoform b	398			E -> K (in Puerto Limon; class I).		cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			ovary(4)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TACACGGCCTCGTTGGGCTGC	0.607													15	37					0	0	0	0	T	153760877	T	T	153760877	3	4	259	1	0	0	0	0	1	0	0	0	6180	893	31	1	371	1	G6PD	23	153760877	Missense_Mutation	SNP	C	TCGA-CV-7424-01A-11D-2078-08	5133540	153760877	1509683	210	47240											
EPHA2	1969	broad.mit.edu	37	chr1	16464477	16464478	+	Frame_Shift_Ins	INS	-	G	G																															tcgctcactgtcacactggtINSgcgggtcagtccgtgaggag																								rs139909813		TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:16464477_16464478insG	uc001aya.1	-	5	1319_1320	c.1182_1183insC	c.(1180-1185)CGCACCfs	p.R394fs	EPHA2_uc010oca.1_Frame_Shift_Ins_p.R394fs	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	394_395	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GTCACACTGGTGCGGGTCAGTC	0.644													---	---	---								G	16464478	G	G	16464477	7	5	260	1	0	1	1	0	0	0	0	0	5191	1696	59	0	1799	0	EPHA2	1	16464477	Frame_Shift_Ins	INS	-	TCGA-CV-7425-01A-11D-2078-08		16464477	232786144	1	47241											
ARID1A	8289	broad.mit.edu	37	chr1	27102150	27102150	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgggcattagataccatcaaCatcctgctgtatgatgacaa	13	11	8	9	0	1	3	1	2	0	1	2	3	2	3	2	1	3	3	2	1	5	3	rs149468118	byFrequency	TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:27102150C>T	uc001bmv.1	+	19	5449	c.5076C>T	c.(5074-5076)AAC>AAT	p.N1692N	ARID1A_uc001bmt.1_Silent_p.N1691N|ARID1A_uc001bmu.1_Silent_p.N1475N|ARID1A_uc001bmx.1_Silent_p.N538N|ARID1A_uc009vsm.1_Silent_p.N20N|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1692					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ATACCATCAACATCCTGCTGT	0.498			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								7	24					0	0	0	0	T	27102150	T	T	27102150	2	4	260	1	0	0	0	0	0	0	0	1	913	477	17	4		4	ARID1A	1	27102150	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	10637673	27102150	222148471	2	47242											
BAI2	576	broad.mit.edu	37	chr1	32193839	32193839	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggaacttctggttgagctCgtggtagagttctgaatgcc	7	13	14	7	1	2	3	0	2	2	1	3	4	2	4	1	3	3	4	1	3	3	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:32193839C>T	uc001btn.2	-	31	4813	c.4459G>A	c.(4459-4461)GAG>AAG	p.E1487K	BAI2_uc001btm.2_Missense_Mutation_p.E481K|BAI2_uc001btp.1_Missense_Mutation_p.E481K|BAI2_uc010ogn.1_Missense_Mutation_p.E457K|BAI2_uc010ogo.1_Missense_Mutation_p.E1096K|BAI2_uc010ogp.1_Missense_Mutation_p.E1420K|BAI2_uc010ogq.1_Missense_Mutation_p.E1453K|BAI2_uc001bto.2_Missense_Mutation_p.E1486K	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	1487	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TGGTTGAGCTCGTGGTAGAGT	0.637													6	26					0	0	0	0	T	32193839	T	T	32193839	3	4	260	1	0	0	0	0	1	0	0	0	1301	893	31	1	310	1	BAI2	1	32193839	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	5091689	32193839	217056782	3	47243											
IPP	3652	broad.mit.edu	37	chr1	46206708	46206708	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctaagaagacctggtattCatcctcaatgctaagctctt	12	12	7	10	0	3	2	2	0	1	2	4	2	4	2	2	1	3	4	2	1	5	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:46206708C>T	uc001cou.2	-	3	856	c.589G>A	c.(589-591)GAA>AAA	p.E197K	IPP_uc001cos.3_Missense_Mutation_p.E197K	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	197						actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACCTGGTATTCATCCTCAATG	0.413													23	61					0	0	0	0	T	46206708	T	T	46206708	3	4	260	1	0	0	0	0	1	0	0	0	7839	835	29	2	1295	2	IPP	1	46206708	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	14012869	46206708	203043913	4	47244											
NEGR1	257194	broad.mit.edu	37	chr1	72400876	72400876	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatctggaggctgtagtcccTtttattcaatgttgaaattg	9	17	9	6	0	2	1	1	1	1	0	3	2	3	2	1	2	0	3	1	2	5	7			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:72400876T>G	uc001dfw.2	-	2	395	c.295A>C	c.(295-297)AGG>CGG	p.R99R	NEGR1_uc001dfv.2_5'UTR|NEGR1_uc010oqs.1_Silent_p.R99R	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	99	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		CTGTAGTCCCTTTTATTCAAT	0.453													16	60					0	0	0	0	G	72400876	G	G	72400876	2	3	260	1	0	0	0	0	0	0	0	1	10371	1608	56	5		5	NEGR1	1	72400876	Silent	SNP	T	TCGA-CV-7425-01A-11D-2078-08	26194168	72400876	176849745	5	47245											
RPF1	80135	broad.mit.edu	37	chr1	84961625	84961625	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgaataattttacaacaCggctgggtcattcaattgga	12	14	8	7	1	3	1	2	1	1	0	3	2	3	2	0	3	2	1	0	3	5	6	rs139410871		TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:84961625C>T	uc001djv.3	+	7	805	c.760C>T	c.(760-762)CGG>TGG	p.R254W		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	254	Brix.				rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						TTTTACAACACGGCTGGGTCA	0.383													12	37					0	0	0	0	T	84961625	T	T	84961625	3	4	260	1	0	0	0	0	1	0	0	0	13611	527	19	1	786	1	RPF1	1	84961625	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	12560749	84961625	164288996	6	47246											
CLK2	1196	broad.mit.edu	37	chr1	155234031	155234031	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtctttcggatcatccGggaagggataggacccaaga	10	9	12	10	2	2	1	1	0	1	1	4	5	3	5	3	4	0	0	3	4	3	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:155234031G>A	uc001fjy.2	-	11	1497	c.1207C>T	c.(1207-1209)CGG>TGG	p.R403W	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjs.2_5'Flank|SCAMP3_uc001fju.2_5'Flank|SCAMP3_uc001fjv.2_5'Flank|SCAMP3_uc001fjt.2_5'Flank|CLK2_uc001fjw.2_Missense_Mutation_p.R402W|CLK2_uc001fjx.2_Missense_Mutation_p.R175W|CLK2_uc009wqm.2_Missense_Mutation_p.R403W	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	403	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CGGATCATCCGGGAAGGGATA	0.443								Other_conserved_DNA_damage_response_genes					16	48					0	0	0	0	A	155234031	A	A	155234031	3	1	260	1	0	0	0	0	1	0	0	0	3552	1115	39	1	304	1	CLK2	1	155234031	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	70272406	155234031	94016590	7	47247											
CD1E	913	broad.mit.edu	37	chr1	158325354	158325354	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggggagtcagaactgaaacGgaaaggtgagcccaactctc	14	5	13	9	1	2	3	1	2	1	1	3	5	2	5	1	4	4	0	1	4	4	0			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:158325354G>A	uc001fse.2	+	3	859	c.620G>A	c.(619-621)CGG>CAG	p.R207Q	CD1E_uc010pid.1_Missense_Mutation_p.R205Q|CD1E_uc010pie.1_Missense_Mutation_p.R108Q|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.R207Q|CD1E_uc001fsk.2_Intron|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.R207Q|CD1E_uc001fry.2_Missense_Mutation_p.R207Q|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.R207Q|CD1E_uc009wsv.2_Missense_Mutation_p.R108Q|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	207	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					GAACTGAAACGGAAAGGTGAG	0.453													5	15					0	0	0	0	A	158325354	A	A	158325354	3	1	260	1	0	0	0	0	1	0	0	0	2993	1116	39	1	630	1	CD1E	1	158325354	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	3091323	158325354	90925267	8	47248											
SPTA1	6708	broad.mit.edu	37	chr1	158631136	158631136	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaatgcgtggttcatggctgGcaatgttctccaggatgact	8	12	13	8	1	2	1	1	1	1	0	3	3	2	2	1	4	1	4	1	4	2	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:158631136G>A	uc001fst.1	-	18	2727	c.2528C>T	c.(2527-2529)GCC>GTC	p.A843V		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	843	Spectrin 9.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTCATGGCTGGCAATGTTCTC	0.423													4	81					0	0	0	0	A	158631136	A	A	158631136	3	1	260	1	0	0	0	0	1	0	0	0	15182	1203	42	4	4871	4	SPTA1	1	158631136	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	305782	158631136	90619485	9	47249											
SPTA1	6708	broad.mit.edu	37	chr1	158655086	158655086	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caacacttcctgacgcctctCctggatctcttctgctgttt	5	15	6	15	1	3	1	0	1	3	0	6	2	4	2	3	1	2	2	3	1	1	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:158655086C>T	uc001fst.1	-	2	275	c.76G>A	c.(76-78)GAG>AAG	p.E26K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	26	Spectrin 1.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TGACGCCTCTCCTGGATCTCT	0.353													22	74					0	0	0	0	T	158655086	T	T	158655086	3	4	260	1	0	0	0	0	1	0	0	0	15182	864	30	2	7387	2	SPTA1	1	158655086	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	23950	158655086	90595535	10	47250											
TBX19	9095	broad.mit.edu	37	chr1	168274332	168274332	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgctcctctgcctctgcctGctccccacacccaccatggc	4	8	6	23	1	2	0	0	0	2	0	4	0	4	0	8	1	3	2	8	1	0	0			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:168274332G>T	uc001gfl.2	+	6	865	c.814G>T	c.(814-816)GCT>TCT	p.A272S	TBX19_uc001gfj.3_Intron|TBX19_uc001gfm.2_5'UTR	NM_005149	NP_005140	O60806	TBX19_HUMAN	T-box 19	272					anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)					GCCTCTGCCTGCTCCCCACAC	0.552													22	54					7.41877e-09	8.54772e-09	1	0	T	168274332	T	T	168274332	3	4	260	1	0	0	0	0	1	0	0	0	15720	1319	46	4	836	4	TBX19	1	168274332	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	9619246	168274332	80976289	11	47251											
NPHS2	7827	broad.mit.edu	37	chr1	179544754	179544754	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccgctcgctctccaacagCgccaccacctcggtgccctc	5	6	9	21	4	1	0	0	0	1	0	5	0	1	0	6	2	3	2	6	2	1	0			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:179544754C>T	uc001gmq.3	-	1	331	c.246G>A	c.(244-246)GCG>GCA	p.A82A	NPHS2_uc009wxi.2_Silent_p.A82A	NM_014625	NP_055440	Q9NP85	PODO_HUMAN	podocin	82	Cytoplasmic (Potential).				excretion	integral to plasma membrane	protein binding				0						TCTCCAACAGCGCCACCACCT	0.672													7	15					0	0	0	0	T	179544754	T	T	179544754	2	4	260	1	0	0	0	0	0	0	0	1	10637	755	27	1		1	NPHS2	1	179544754	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	11270422	179544754	69705867	12	47252											
LAMC2	3918	broad.mit.edu	37	chr1	183192457	183192457	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaccaagacttacacattCaggtaaaaagagagaccata	18	7	6	10	0	2	3	2	0	0	3	2	4	2	3	2	1	1	1	2	1	6	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:183192457C>T	uc001gqa.2	+	7	1265	c.951C>T	c.(949-951)TTC>TTT	p.F317F	LAMC2_uc001gpz.3_Silent_p.F317F|LAMC2_uc010poa.1_Silent_p.F17F	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	317	Laminin IV type A.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						CTTACACATTCAGGTAAAAAG	0.393													16	36					0	0	0	0	T	183192457	T	T	183192457	2	4	260	1	0	0	0	0	0	0	0	1	8655	825	29	2		2	LAMC2	1	183192457	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	3647703	183192457	66058164	13	47253											
HMCN1	83872	broad.mit.edu	37	chr1	186158913	186158913	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acgagaagcagagacctaccGcatgagggtccgagcctcat	12	5	12	12	3	1	3	1	1	0	2	2	6	2	3	4	1	3	2	4	1	2	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:186158913G>T	uc001grq.1	+	107	17040	c.16811G>T	c.(16810-16812)CGC>CTC	p.R5604L	HMCN1_uc001grs.1_Missense_Mutation_p.R1056L	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5604					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAGACCTACCGCATGAGGGTC	0.468													11	35					1.58986e-06	1.7802e-06	1	0	T	186158913	T	T	186158913	3	4	260	1	0	0	0	0	1	0	0	0	7259	1087	38	3	17237	3	HMCN1	1	186158913	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	2966456	186158913	63091708	14	47254											
CACNA1S	779	broad.mit.edu	37	chr1	201022706	201022706	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctggagatgcgggcactctCatctgggtcctgcggggcag	5	8	17	11	2	2	1	1	0	2	1	4	2	3	1	1	5	2	3	1	5	0	0			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr1:201022706C>T	uc001gvv.2	-	30	3903	c.3676G>A	c.(3676-3678)GAG>AAG	p.E1226K		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1226	IV.|Extracellular (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CGGGCACTCTCATCTGGGTCC	0.642													3	35					0	0	0	0	T	201022706	T	T	201022706	3	4	260	1	0	0	0	0	1	0	0	0	2559	835	29	2	2005	2	CACNA1S	1	201022706	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	14863793	201022706	48227915	15	47255											
SNTG2	54221	broad.mit.edu	37	chr2	1079296	1079296	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagaggtgctgacaattcaGaaacaagatgttgtctgtgt	14	11	11	5	0	2	4	1	1	1	3	2	4	2	4	0	1	2	2	0	1	4	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:1079296G>C	uc002qwq.2	+	2	293	c.165G>C	c.(163-165)CAG>CAC	p.Q55H	SNTG2_uc002qwp.2_RNA|SNTG2_uc010ewi.2_Missense_Mutation_p.Q55H	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	55					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		TGACAATTCAGAAACAAGATG	0.498													22	36					0	0	0	0	C	1079296	C	C	1079296	3	2	260	1	0	0	0	0	1	0	0	0	14939	933	33	2	171	2	SNTG2	2	1079296	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08		1079296	242120077	16	47256											
MYCN	4613	broad.mit.edu	37	chr2	16086016	16086016	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccagcgccgcaacgaccttCggtccagctttctcacgctc	6	8	9	18	5	1	0	1	0	1	0	5	1	2	0	4	1	3	3	4	1	1	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:16086016C>T	uc002rci.2	+	3	1492	c.1192C>T	c.(1192-1194)CGG>TGG	p.R398W	MYCN_uc010yjr.1_Missense_Mutation_p.R390W	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	398	Helix-loop-helix motif.				regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CAACGACCTTCGGTCCAGCTT	0.567			A		neuroblastoma								13	69					0	0	0	0	T	16086016	T	T	16086016	3	4	260	1	0	0	0	0	1	0	0	0	10074	875	31	1	1198	1	MYCN	2	16086016	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	15006720	16086016	227113357	17	47257											
MSGN1	343930	broad.mit.edu	37	chr2	17998006	17998006	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccctgtgagcacggcggggCcagcagtgggggcagcgaag	7	3	20	11	3	0	1	0	1	0	0	0	2	0	1	2	5	3	3	2	5	1	0			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-11A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	cf149007-ed33-4a5d-a925-193a5d670349	g.chr2:17998006C>G	uc010yjt.1	+	1	221	c.221C>G	c.(220-222)GCC>GGC	p.A74G		NM_001105569	NP_001099039	A6NI15	MSGN1_HUMAN	mesogenin 1	74					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CACGGCGGGGCCAGCAGTGGG	0.637													4	41					0	0	0	0	G	17998006	G	G	17998006	3	3	260	1	0	0	0	0	1	0	0	0	9922	739	26	4	223	4	MSGN1	2	17998006	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	1911990	17998006	225201367	18	47258											
CCDC88A	55704	broad.mit.edu	37	chr2	55570925	55570925	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttttttctatccatatctcGttccttttttattggcaagg	6	21	5	9	1	2	0	0	0	2	0	5	0	4	0	2	2	0	2	2	2	4	10			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:55570925G>A	uc002ryv.2	-	12	2034	c.1192C>T	c.(1192-1194)CGA>TGA	p.R398*	CCDC88A_uc010yoz.1_Nonsense_Mutation_p.R398*|CCDC88A_uc010ypa.1_Nonsense_Mutation_p.R398*|CCDC88A_uc010ypb.1_Nonsense_Mutation_p.R300*	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	398	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TCCATATCTCGTTCCTTTTTT	0.308													8	14					0	0	0	0	A	55570925	A	A	55570925	4	1	260	1	0	0	0	0	0	1	0	0	2876	1153	40	1	4507	1	CCDC88A	2	55570925	Nonsense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	37572919	55570925	187628448	19	47259											
DOK1	1796	broad.mit.edu	37	chr2	74783065	74783065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaggactgaggccgccgagCgctgtggcctgcatggctcc	6	6	16	13	3	0	2	0	1	0	1	1	4	1	3	4	4	2	3	4	4	0	0			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:74783065C>T	uc002sms.2	+	4	521	c.499C>T	c.(499-501)CGC>TGC	p.R167C	LOXL3_uc010ffm.1_5'Flank|LOXL3_uc002smp.1_5'Flank|LOXL3_uc002smq.1_5'Flank|LOXL3_uc010ffn.1_5'Flank|DOK1_uc002smr.2_Missense_Mutation_p.R28C|DOK1_uc010ffo.2_Missense_Mutation_p.R28C|DOK1_uc002smt.2_Intron|DOK1_uc002smu.2_Intron|DOK1_uc010yrz.1_Missense_Mutation_p.R156C|DOK1_uc002smv.2_Missense_Mutation_p.R28C|DOK1_uc002smw.1_5'UTR	NM_001381	NP_001372	Q99704	DOK1_HUMAN	docking protein 1	167	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding				0						GGCCGCCGAGCGCTGTGGCCT	0.637													12	31					0	0	0	0	T	74783065	T	T	74783065	3	4	260	1	0	0	0	0	1	0	0	0	4718	768	27	1	513	1	DOK1	2	74783065	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	19212140	74783065	168416308	20	47260											
SNRNP200	23020	broad.mit.edu	37	chr2	96942823	96942823	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accacctctggctcacctgcGgatgctgtccttatctacca	7	11	7	16	1	3	0	1	0	2	0	4	1	4	1	5	2	3	2	5	2	2	2	rs150442718		TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:96942823G>A	uc002svu.2	-	42	6174	c.6088C>T	c.(6088-6090)CGC>TGC	p.R2030C	SNRNP200_uc002svt.2_Missense_Mutation_p.R640C|SNRNP200_uc010yuj.1_RNA	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	2030	SEC63 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						GCTCACCTGCGGATGCTGTCC	0.552													9	71					0	0	0	0	A	96942823	A	A	96942823	3	1	260	1	0	0	0	0	1	0	0	0	14916	1116	39	1	338	1	SNRNP200	2	96942823	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	22159758	96942823	146256550	21	47261											
DPP10	57628	broad.mit.edu	37	chr2	116535403	116535403	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttctcccagaggaaggcagCtgtacaggtaagcagtgtgc	10	8	13	10	0	1	1	0	0	1	1	2	2	1	2	1	3	4	5	1	3	3	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:116535403C>A	uc002tla.1	+	15	1811	c.1354C>A	c.(1354-1356)CTG>ATG	p.L452M	DPP10_uc002tlb.1_Missense_Mutation_p.L402M|DPP10_uc002tlc.1_Missense_Mutation_p.L448M|DPP10_uc002tle.2_Missense_Mutation_p.L456M|DPP10_uc002tlf.1_Missense_Mutation_p.L445M	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	452	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AGGAAGGCAGCTGTACAGGTA	0.403													17	41					1.00905e-13	1.1973e-13	1	0	A	116535403	A	A	116535403	3	1	260	1	0	0	0	0	1	0	0	0	4749	796	28	4	1583	4	DPP10	2	116535403	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	19592580	116535403	126663970	22	47262											
LRP1B	53353	broad.mit.edu	37	chr2	140992441	140992441	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagcactgggtcctccccCtatgtacctggcctgtatat	8	11	9	13	0	0	0	0	0	0	0	2	1	2	0	5	2	2	3	5	2	5	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:140992441C>T	uc002tvj.1	-	90	14545	c.13573G>A	c.(13573-13575)GGG>AGG	p.G4525R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4525	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ggtcctccccctatgtacctg	0.06										TSP Lung(27;0.18)			6	29					0	0	0	0	T	140992441	T	T	140992441	3	4	260	1	0	0	0	0	1	0	0	0	9005	681	24	4	234	4	LRP1B	2	140992441	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	24457038	140992441	102206932	23	47263											
LRP1B	53353	broad.mit.edu	37	chr2	141359128	141359128	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtccacagtgtgtctggTgatggatgaggtggtagagc	7	11	17	6	0	1	3	0	2	1	1	2	4	2	4	1	5	1	1	1	5	1	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:141359128T>C	uc002tvj.1	-	42	7852	c.6880A>G	c.(6880-6882)ACC>GCC	p.T2294A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2294	Extracellular (Potential).|LDL-receptor class B 24.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTGTGTCTGGTGATGGATGAG	0.512										TSP Lung(27;0.18)			9	29					0	0	0	0	C	141359128	C	C	141359128	3	2	260	1	0	0	0	0	1	0	0	0	9005	1696	59	5	7119	5	LRP1B	2	141359128	Missense_Mutation	SNP	T	TCGA-CV-7425-01A-11D-2078-08	366687	141359128	101840245	24	47264											
FIGN	55137	broad.mit.edu	37	chr2	164467308	164467308	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcattctgtacataggactcTgtgtagatctctgttggcca	8	14	10	9	0	3	1	0	0	3	1	4	2	3	2	1	2	1	4	1	2	3	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:164467308T>A	uc002uck.1	-	3	1345	c.1034A>T	c.(1033-1035)CAG>CTG	p.Q345L		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	345						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CATAGGACTCTGTGTAGATCT	0.438													21	54					0	0	0	0	A	164467308	A	A	164467308	3	1	260	1	0	0	0	0	1	0	0	0	5923	1580	55	5	1249	5	FIGN	2	164467308	Missense_Mutation	SNP	T	TCGA-CV-7425-01A-11D-2078-08	23108180	164467308	78732065	25	47265											
TTN	7273	broad.mit.edu	37	chr2	179467097	179467097	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctttcactctgaatctgtaCttcctgagctctttcagatt	7	17	6	11	0	5	3	2	2	3	1	6	3	6	3	1	0	2	3	1	0	2	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:179467097C>T	uc010zfg.1	-	232	47552	c.47328G>A	c.(47326-47328)AAG>AAA	p.K15776K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.K9471K|TTN_uc010zfi.1_Silent_p.K9404K|TTN_uc010zfj.1_Silent_p.K9279K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16703							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAATCTGTACTTCCTGAGCT	0.418													4	41					0	0	0	0	T	179467097	T	T	179467097	2	4	260	1	0	0	0	0	0	0	0	1	16803	564	20	4		4	TTN	2	179467097	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	14999789	179467097	63732276	26	47266											
HIBCH	26275	broad.mit.edu	37	chr2	191116990	191116990	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagtaaccaagttttccttgGagtcgtggcaagaaataacc	14	10	9	8	1	0	1	0	0	0	1	2	2	1	2	3	2	2	3	3	2	6	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:191116990G>A	uc002uru.2	-	8	644	c.561C>T	c.(559-561)CTC>CTT	p.L187L	HIBCH_uc002urv.2_Silent_p.L187L	NM_014362	NP_055177	Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-Coenzyme A hydrolase isoform	187				LPRLQGKLGYFLALT -> FATTPRKTWLLPCIN (in Ref. 1; AAC52114).	branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			GTTTTCCTTGGAGTCGTGGCA	0.363													21	33					0	0	0	0	A	191116990	A	A	191116990	2	1	260	1	0	0	0	0	0	0	0	1	7139	1161	41	2		2	HIBCH	2	191116990	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	11649893	191116990	52082383	27	47267											
DNAH7	56171	broad.mit.edu	37	chr2	196726485	196726485	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttgaaggtggagattaattcGaggtaagaggtaggagtcac	13	10	15	3	1	1	3	1	1	0	2	2	6	1	4	0	5	0	2	0	5	4	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:196726485G>C	uc002utj.3	-	42	7793	c.7692C>G	c.(7690-7692)CTC>CTG	p.L2564L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2564					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGATTAATTCGAGGTAAGAGG	0.308													17	24					0	0	0	0	C	196726485	C	C	196726485	2	2	260	1	0	0	0	0	0	0	0	1	4628	1045	37	3		3	DNAH7	2	196726485	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	5609495	196726485	46472888	28	47268											
CASP8	841	broad.mit.edu	37	chr2	202150030	202150030	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttgccagagcctgagagagCgatgtcctcggtaagttttg	8	12	13	8	2	0	3	0	1	0	2	2	5	1	3	3	1	3	2	3	1	1	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:202150030C>T	uc002uxr.1	+	9	1503	c.1294C>T	c.(1294-1296)CGA>TGA	p.R432*	CASP8_uc002uxp.1_Nonsense_Mutation_p.R449*|CASP8_uc002uxq.1_Nonsense_Mutation_p.R417*|CASP8_uc002uxt.1_Nonsense_Mutation_p.R491*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.R417*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.R348*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	432					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CCTGAGAGAGCGATGTCCTCG	0.507										HNSCC(4;0.00038)			21	45					0	0	0	0	T	202150030	T	T	202150030	4	4	260	1	0	0	0	0	0	1	0	0	2689	760	27	1	1601	1	CASP8	2	202150030	Nonsense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	5423545	202150030	41049343	29	47269											
TMEM198	130612	broad.mit.edu	37	chr2	220413898	220413898	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcagccggcagcgccgacGcgtgcaactgatgcggattc	8	6	13	14	6	1	1	1	1	0	0	2	3	1	2	2	2	5	2	2	2	1	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:220413898G>A	uc002vme.2	+	5	1352	c.767G>A	c.(766-768)CGC>CAC	p.R256H	TMEM198_uc002vmf.2_Missense_Mutation_p.R256H|hsa-mir-3132|MI0014152_5'Flank	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	256	Arg-rich.					integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CAGCGCCGACGCGTGCAACTG	0.627													16	99					0	0	0	0	A	220413898	A	A	220413898	3	1	260	1	0	0	0	0	1	0	0	0	16185	1087	38	1	777	1	TMEM198	2	220413898	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	18263868	220413898	22785475	30	47270											
TRAF3IP1	26146	broad.mit.edu	37	chr2	239237417	239237417	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgacctcaagatctcaggaaTtggataataagaatgtgcga	15	10	10	6	1	2	3	2	1	1	2	3	6	2	5	1	2	1	0	1	2	5	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:239237417T>C	uc002vye.2	+	4	564	c.445T>C	c.(445-447)TTG>CTG	p.L149L	TRAF3IP1_uc002vyf.2_Silent_p.L149L	NM_015650	NP_056465	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting	149	Abolishes microtubules-binding when missing.					cytoplasm|cytoskeleton	protein binding			ovary(1)	1		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		ATCTCAGGAATTGGATAATAA	0.458													3	24					0	0	0	0	C	239237417	C	C	239237417	2	2	260	1	0	0	0	0	0	0	0	1	16507	1490	52	5		5	TRAF3IP1	2	239237417	Silent	SNP	T	TCGA-CV-7425-01A-11D-2078-08	18823519	239237417	3961956	31	47271											
MTERFD2	130916	broad.mit.edu	37	chr2	242035518	242035518	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcatcattgtcctcctcAtcatcgtcatcctcatcctc	6	15	2	18	1	6	0	6	0	0	0	13	0	11	0	5	0	0	0	5	0	0	1	rs10203977		TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr2:242035518A>C	uc002wan.1	-	3	1621	c.1128T>G	c.(1126-1128)GAT>GAG	p.D376E	MTERFD2_uc010zoj.1_Missense_Mutation_p.D159E	NM_182501	NP_872307	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	347										ovary(1)	1		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		tgtcctcctcatcatcgtcat	0.214													22	28					0	0	0	0	C	242035518	C	C	242035518	3	2	260	1	0	0	0	0	1	0	0	0	9973	214	8	5	108	5	MTERFD2	2	242035518	Missense_Mutation	SNP	A	TCGA-CV-7425-01A-11D-2078-08	2798101	242035518	1163855	32	47272											
TADA3	10474	broad.mit.edu	37	chr3	9822068	9822068	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccagcagcttcaggatgctCtcacgctccttcagagtctt	7	12	8	14	1	4	1	3	0	2	1	7	2	6	2	2	1	3	4	2	1	0	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr3:9822068C>G	uc003bsx.1	-	9	1820	c.1272G>C	c.(1270-1272)GAG>GAC	p.E424D	TADA3_uc010hcn.1_Missense_Mutation_p.E424D|TADA3_uc003bsw.1_Missense_Mutation_p.E253D	NM_006354	NP_006345	O75528	TADA3_HUMAN	transcriptional adaptor 3 isoform a	424					estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity				0						TCAGGATGCTCTCACGCTCCT	0.587													9	30					0	0	0	0	G	9822068	G	G	9822068	3	3	260	1	0	0	0	0	1	0	0	0	15578	912	32	2	30	2	TADA3	3	9822068	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08		9822068	188200362	33	47273											
MLH1	4292	broad.mit.edu	37	chr3	37056031	37056031	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcatcttcttactcttcatCaaccgtaagttaaaaagaac	14	13	4	10	1	5	1	2	0	3	1	5	1	5	1	1	0	4	3	1	0	7	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr3:37056031C>G	uc003cgl.2	+	9	846	c.786C>G	c.(784-786)ATC>ATG	p.I262M	MLH1_uc011aye.1_Missense_Mutation_p.I21M|MLH1_uc011ayb.1_Missense_Mutation_p.I21M|MLH1_uc010hge.2_Missense_Mutation_p.I262M|MLH1_uc003cgn.3_Missense_Mutation_p.I21M|MLH1_uc011ayc.1_Missense_Mutation_p.I164M|MLH1_uc011ayd.1_Missense_Mutation_p.I21M|MLH1_uc003cgo.2_Missense_Mutation_p.I21M|MLH1_uc010hgg.1_Translation_Start_Site|MLH1_uc010hgh.1_Intron|MLH1_uc010hgi.1_Translation_Start_Site|MLH1_uc010hgj.1_Intron|MLH1_uc010hgk.2_Translation_Start_Site|MLH1_uc010hgl.1_Translation_Start_Site	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	262			Missing (in HNPCC2).|Missing (in HNPCC2).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						TACTCTTCATCAACCGTAAGT	0.383		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				10	25					0	0	0	0	G	37056031	G	G	37056031	3	3	260	1	0	0	0	0	1	0	0	0	9670	816	29	2	820	2	MLH1	3	37056031	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	27233963	37056031	160966399	34	47274											
CYP8B1	1582	broad.mit.edu	37	chr3	42915828	42915828	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgtaggatgcaggcggtagCggaagcgcacatcgtggctg	8	7	17	9	4	0	0	0	0	0	0	1	2	0	2	0	5	3	5	0	5	3	2	rs145159025	by1000genomes	TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr3:42915828C>T	uc003cmh.2	-	1	1806	c.1481G>A	c.(1480-1482)CGC>CAC	p.R494H	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	494					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CAGGCGGTAGCGGAAGCGCAC	0.582													7	31					0	0	0	0	T	42915828	T	T	42915828	3	4	260	1	0	0	0	0	1	0	0	0	4215	768	27	1	28	1	CYP8B1	3	42915828	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	5859797	42915828	155106602	35	47275											
CCDC51	79714	broad.mit.edu	37	chr3	48476325	48476325	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtggaggtcgctcgttgctGaatgctgtgccccagggctc	4	11	15	11	2	0	1	0	1	0	0	3	2	0	2	2	3	3	5	2	3	1	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr3:48476325G>A	uc003csz.2	-	2	335	c.214C>T	c.(214-216)CAG>TAG	p.Q72*	CCDC51_uc003cta.2_5'UTR|CCDC51_uc003ctb.2_5'UTR|CCDC51_uc003ctc.2_Nonsense_Mutation_p.Q72*|CCDC51_uc003ctd.2_5'UTR	NM_024661	NP_078937	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	72						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCTCGTTGCTGAATGCTGTGC	0.612													16	59					0	0	0	0	A	48476325	A	A	48476325	4	1	260	1	0	0	0	0	0	1	0	0	2834	1299	45	2	1033	2	CCDC51	3	48476325	Nonsense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	5560497	48476325	149546105	36	47276											
COL7A1	1294	broad.mit.edu	37	chr3	48617463	48617463	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagacccagcgcagcccttaCcagccgtcccgggggtcctg	6	5	12	18	3	0	1	0	0	0	1	2	1	2	1	6	2	4	1	6	2	1	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr3:48617463C>A	uc003ctz.2	-	56	5125	c.5124_splice	c.e56+1	p.L1708_splice	MIR711_hsa-mir-711|MI0012488_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor						cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCAGCCCTTACCAGCCGTCCC	0.592													10	29					0.00829132	0.00856052	1	0	A	48617463	A	A	48617463	5	1	260	1	0	0	0	0	0	0	1	0	3719	521	18	4	3961	4	COL7A1	3	48617463	Splice_Site	SNP	C	TCGA-CV-7425-01A-11D-2078-08	141138	48617463	149404967	37	47277											
C3orf30	152405	broad.mit.edu	37	chr3	118865966	118865966	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtaaagactcaccaccaagtGtacggccaagccactgaact	14	6	8	13	1	1	2	1	1	0	1	1	2	1	2	4	1	3	2	4	1	6	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr3:118865966G>C	uc003ecb.1	+	1	970	c.930G>C	c.(928-930)GTG>GTC	p.V310V	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Silent_p.V310V	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	310										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		ACCACCAAGTGTACGGCCAAG	0.493													7	33					0	0	0	0	C	118865966	C	C	118865966	2	2	260	1	0	0	0	0	0	0	0	1	2230	1364	48	4		4	C3orf30	3	118865966	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	70248503	118865966	79156464	38	47278											
GOLIM4	27333	broad.mit.edu	37	chr3	167742370	167742370	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	attgtcctcctgctggtctgGatttcctgccatctgttgga	4	16	10	11	0	2	0	0	0	2	0	5	2	5	2	4	3	2	2	4	3	0	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr3:167742370G>C	uc003ffe.2	-	14	2148	c.1804C>G	c.(1804-1806)CCA>GCA	p.P602A	GOLIM4_uc011bpe.1_Missense_Mutation_p.P603A|GOLIM4_uc011bpf.1_Missense_Mutation_p.P575A|GOLIM4_uc011bpg.1_Missense_Mutation_p.P574A	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	602	Glu-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						TGCTGGTCTGGATTTCCTGCC	0.463													6	28					0	0	0	0	C	167742370	C	C	167742370	3	2	260	1	0	0	0	0	1	0	0	0	6603	1174	41	2	298	2	GOLIM4	3	167742370	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	48876404	167742370	30280060	39	47279											
GBA3	57733	broad.mit.edu	37	chr4	22820400	22820400	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgcatggtctcttctggatAactttgagtggaaccaggga	9	12	13	7	0	2	1	0	1	2	0	3	4	2	4	1	4	3	1	1	4	2	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr4:22820400A>T	uc003gqp.3	+	5	1355	c.1264A>T	c.(1264-1266)AAC>TAC	p.N422Y	GBA3_uc010iep.2_Missense_Mutation_p.N115Y|GBA3_uc011bxo.1_Missense_Mutation_p.N423Y	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	422					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						TCTTCTGGATAACTTTGAGTG	0.423													3	19					0	0	0	0	T	22820400	T	T	22820400	3	4	260	1	0	0	0	0	1	0	0	0	6303	362	13	5	1282	5	GBA3	4	22820400	Missense_Mutation	SNP	A	TCGA-CV-7425-01A-11D-2078-08		22820400	168333876	40	47280											
CHRNA9	55584	broad.mit.edu	37	chr4	40339349	40339349	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcaggatccccagtgacctCgtgtggaggccagacatcgt	9	8	12	12	2	1	2	1	1	0	1	4	4	2	4	4	3	0	0	4	3	0	0	rs148584579	byFrequency	TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr4:40339349C>T	uc003gva.1	+	3	349	c.333C>T	c.(331-333)CTC>CTT	p.L111L		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	111	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	CCAGTGACCTCGTGTGGAGGC	0.468													8	23					0	0	0	0	T	40339349	T	T	40339349	2	4	260	1	0	0	0	0	0	0	0	1	3404	871	31	1		1	CHRNA9	4	40339349	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	17518949	40339349	150814927	41	47281											
FAT4	79633	broad.mit.edu	37	chr4	126241794	126241794	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgtcagtggttattcacGtgagggactttaatgacaat	12	13	10	6	1	2	2	2	2	0	0	2	3	2	3	0	2	0	1	0	2	4	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr4:126241794G>A	uc003ifj.3	+	1	4228	c.4228G>A	c.(4228-4230)GTG>ATG	p.V1410M		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1410	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGTTATTCACGTGAGGGACTT	0.383													25	100					0	0	0	0	A	126241794	A	A	126241794	3	1	260	1	0	0	0	0	1	0	0	0	5724	1145	40	1	4230	1	FAT4	4	126241794	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	85902445	126241794	64912482	42	47282											
FBXW7	55294	broad.mit.edu	37	chr4	153247377	153247379	+	In_Frame_Del	DEL	AAC	-	-																															gtggcatctcgagaaccgctAacaactctgcagagggagaa																										TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr4:153247377_153247379delAAC	uc003ims.2	-	10	1572_1574	c.1423_1425delGTT	c.(1423-1425)GTTdel	p.V475del	FBXW7_uc011cii.1_In_Frame_Del_p.V475del|FBXW7_uc003imt.2_In_Frame_Del_p.V475del|FBXW7_uc011cih.1_In_Frame_Del_p.V299del|FBXW7_uc003imq.2_In_Frame_Del_p.V395del|FBXW7_uc003imr.2_In_Frame_Del_p.V357del	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	475	WD 3.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				GAGAACCGCTAACAACTCTGCAG	0.389			Mis|N|D|F		colorectal|endometrial|T-ALL								---	---	---								-	153247379	-	-	153247377	7	5	260	1	0	1	0	1	0	0	0	0	5801	349	13	0	710	0	FBXW7	4	153247377	In_Frame_Del	DEL	AAC	TCGA-CV-7425-01A-11D-2078-08	27005583	153247377	37906899	43	47283											
PLCXD3	345557	broad.mit.edu	37	chr5	41382584	41382584	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacagtttctggctgctcAggacctactggagaggcttc	7	11	13	10	0	2	1	1	0	1	1	3	4	2	3	1	5	2	4	1	5	1	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr5:41382584A>G	uc003jmm.1	-	2	258	c.156T>C	c.(154-156)CCT>CCC	p.P52P		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	52	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						CTGGCTGCTCAGGACCTACTG	0.448													8	52					0	0	0	0	G	41382584	G	G	41382584	2	3	260	1	0	0	0	0	0	0	0	1	12098	175	7	5		5	PLCXD3	5	41382584	Silent	SNP	A	TCGA-CV-7425-01A-11D-2078-08		41382584	139532676	44	47284											
THBS4	7060	broad.mit.edu	37	chr5	79336023	79336023	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagctgcagactaaaagttCagccaccatcttcggtcttt	11	11	7	12	1	3	1	1	0	2	1	4	1	3	1	2	1	3	3	2	1	3	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr5:79336023C>T	uc003kgh.2	+	3	535	c.212C>T	c.(211-213)TCA>TTA	p.S71L		NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	71	TSP N-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		ACTAAAAGTTCAGCCACCATC	0.443													11	31					0	0	0	0	T	79336023	T	T	79336023	3	4	260	1	0	0	0	0	1	0	0	0	15922	838	29	2	218	2	THBS4	5	79336023	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	37953439	79336023	101579237	45	47285											
PCDHA3	56145	broad.mit.edu	37	chr5	140181874	140181874	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtattagaagactctccActtagcacagtcatcgctct	10	12	6	13	1	3	2	1	0	2	2	5	2	3	2	2	0	1	3	2	0	4	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr5:140181874A>T	uc003lhf.2	+	1	1092	c.1092A>T	c.(1090-1092)CCA>CCT	p.P364P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.P364P	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	364	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGACTCTCCACTTAGCACAG	0.488													24	58					0	0	0	0	T	140181874	T	T	140181874	2	4	260	1	0	0	0	0	0	0	0	1	11579	146	6	5		5	PCDHA3	5	140181874	Silent	SNP	A	TCGA-CV-7425-01A-11D-2078-08	60845851	140181874	40733386	46	47286											
PCDHA13	56136	broad.mit.edu	37	chr5	140263705	140263705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagctggcggcggtcggcGcgcgcatcccgttccgcgtg	2	7	17	15	9	0	0	0	0	0	0	3	0	2	0	2	4	2	4	2	4	0	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr5:140263705G>A	uc003lif.2	+	1	1852	c.1852G>A	c.(1852-1854)GCG>ACG	p.A618T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.A618T|PCDHA13_uc003lid.2_Missense_Mutation_p.A618T	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	618	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGGTCGGCGCGCGCATCCC	0.687													25	48					0	0	0	0	A	140263705	A	A	140263705	3	1	260	1	0	0	0	0	1	0	0	0	11577	1087	38	1	1854	1	PCDHA13	5	140263705	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	81831	140263705	40651555	47	47287											
PCDHB8	56128	broad.mit.edu	37	chr5	140558774	140558774	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaaataagttgctccattCaggaggatctacccttcctc	11	11	8	11	0	2	0	1	0	1	0	5	3	4	3	3	3	2	2	3	3	4	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr5:140558774C>T	uc011dai.1	+	1	1345	c.1159C>T	c.(1159-1161)CAG>TAG	p.Q387*	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	387	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTGCTCCATTCAGGAGGATCT	0.458													15	135					0	0	0	0	T	140558774	T	T	140558774	4	4	260	1	0	0	0	0	0	1	0	0	11602	827	29	2	1161	2	PCDHB8	5	140558774	Nonsense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	295069	140558774	40356486	48	47288											
KIF4B	285643	broad.mit.edu	37	chr5	154395571	154395571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaagcgactcaaggatgctCtccagaaacaacgagaggtc	15	5	10	11	2	2	2	1	0	1	2	4	5	2	3	1	2	4	1	1	2	4	0			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr5:154395571C>T	uc010jih.1	+	1	2312	c.2152C>T	c.(2152-2154)CTC>TTC	p.L718F		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	718	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CAAGGATGCTCTCCAGAAACA	0.473													13	33					0	0	0	0	T	154395571	T	T	154395571	3	4	260	1	0	0	0	0	1	0	0	0	8343	913	32	2	2154	2	KIF4B	5	154395571	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	13836797	154395571	26519689	49	47289											
GPRIN1	114787	broad.mit.edu	37	chr5	176025296	176025296	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctccttttccccccgtcgCtggctcagcctttactgcag	4	13	7	17	2	2	0	1	0	1	0	5	0	3	0	5	1	3	3	5	1	1	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr5:176025296C>T	uc003meo.1	-	2	1715	c.1540G>A	c.(1540-1542)GCG>ACG	p.A514T		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	514						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCCCGTCGCTGGCTCAGCC	0.627													12	34					0	0	0	0	T	176025296	T	T	176025296	3	4	260	1	0	0	0	0	1	0	0	0	6768	797	28	4	1490	4	GPRIN1	5	176025296	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	21629725	176025296	4889964	50	47290											
HLA-C	3107	broad.mit.edu	37	chr6	31239382	31239382	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggggtcactcaccgtcctCgctctggttgtagtagccgc	4	10	12	15	4	3	0	2	0	1	0	5	0	4	0	4	3	1	4	4	3	2	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr6:31239382C>A	uc003nsy.2	-	2	344	c.337G>T	c.(337-339)GAG>TAG	p.E113*	HLA-C_uc011dnj.1_Nonsense_Mutation_p.E85*|HLA-C_uc003nsx.2_5'UTR|HLA-C_uc003nsz.2_Nonsense_Mutation_p.E113*|HLA-C_uc010jsl.2_Nonsense_Mutation_p.E113*|HLA-C_uc003nta.2_Nonsense_Mutation_p.E113*|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_5'UTR|HLA-B_uc003ntf.2_Intron	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	113	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						TCACCGTCCTCGCTCTGGTTG	0.692													5	20					1.23904e-05	1.34019e-05	1	0	A	31239382	A	A	31239382	4	1	260	1	0	0	0	0	0	1	0	0	7236	893	31	3	791	3	HLA-C	6	31239382	Nonsense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08		31239382	139875685	51	47291											
POU3F2	5454	broad.mit.edu	37	chr6	99283616	99283616	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaactgggatttacccaagcGgacgtggggctggctctggg	8	8	16	9	2	1	0	0	0	1	0	1	2	1	2	1	6	3	2	1	6	3	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr6:99283616G>A	uc003ppe.2	+	1	1037	c.867G>A	c.(865-867)GCG>GCA	p.A289A		NM_005604	NP_005595	P20265	PO3F2_HUMAN	POU domain, class 3, transcription factor 2	289	POU-specific.				positive regulation of cell proliferation		identical protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0355)		TTACCCAAGCGGACGTGGGGC	0.607													39	153					0	0	0	0	A	99283616	A	A	99283616	2	1	260	1	0	0	0	0	0	0	0	1	12330	1103	39	1		1	POU3F2	6	99283616	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	68044234	99283616	71831451	52	47292											
LIN28B	389421	broad.mit.edu	37	chr6	105474273	105474273	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccttgagtcaatacgggtaaCaggacctggtgggagcccct	9	8	13	11	1	1	1	1	1	0	0	1	3	1	3	4	4	3	1	4	4	3	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr6:105474273C>G	uc003pqv.1	+	3	502	c.299C>G	c.(298-300)ACA>AGA	p.T100R	LIN28B_uc010kda.1_Missense_Mutation_p.T60R	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	100	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				ATACGGGTAACAGGACCTGGT	0.403													21	87					0	0	0	0	G	105474273	G	G	105474273	3	3	260	1	0	0	0	0	1	0	0	0	8848	478	17	4	309	4	LIN28B	6	105474273	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	6190657	105474273	65640794	53	47293											
SYNE1	23345	broad.mit.edu	37	chr6	152674420	152674420	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaacgtcttcaatttcttcCccatcattactgtatctact	9	16	2	14	1	5	0	2	0	3	0	6	0	6	0	3	0	3	1	3	0	5	6			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr6:152674420C>T	uc010kiw.2	-	69	11833	c.11231G>A	c.(11230-11232)GGG>GAG	p.G3744E	SYNE1_uc003qot.3_Missense_Mutation_p.G3729E|SYNE1_uc003qou.3_Missense_Mutation_p.G3744E|SYNE1_uc010kja.1_Missense_Mutation_p.G449E	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3744	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAATTTCTTCCCCATCATTAC	0.423										HNSCC(10;0.0054)			38	149					0	0	0	0	T	152674420	T	T	152674420	3	4	260	1	0	0	0	0	1	0	0	0	15511	623	22	4	15547	4	SYNE1	6	152674420	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	47200147	152674420	18440647	54	47294											
SYNJ2	8871	broad.mit.edu	37	chr6	158449945	158449945	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atagctttgaagaaaatcctCagctcgggggtgttctattt	10	14	10	7	1	2	2	1	1	1	1	4	2	3	2	1	2	2	3	1	2	5	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr6:158449945C>G	uc003qqx.1	+	3	447	c.372C>G	c.(370-372)CTC>CTG	p.L124L	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Silent_p.L124L|SYNJ2_uc003qqy.1_5'UTR|SYNJ2_uc011efn.1_Silent_p.L73L|SYNJ2_uc010kjo.1_Silent_p.L73L	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	124	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		AGAAAATCCTCAGCTCGGGGG	0.512													12	29					0	0	0	0	G	158449945	G	G	158449945	2	3	260	1	0	0	0	0	0	0	0	1	15519	813	29	2		2	SYNJ2	6	158449945	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	5775525	158449945	12665122	55	47295											
DGKB	1607	broad.mit.edu	37	chr7	14758228	14758228	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtaacagacaatgtccttCagatggattacttctgggga	12	11	11	7	0	2	2	1	0	1	2	3	4	3	4	1	4	2	1	1	4	3	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr7:14758228C>T	uc003ssz.2	-	5	592	c.405G>A	c.(403-405)CTG>CTA	p.L135L	DGKB_uc011jxt.1_Silent_p.L128L|DGKB_uc003sta.2_Silent_p.L135L|DGKB_uc011jxu.1_Silent_p.L135L|DGKB_uc011jxv.1_Silent_p.L135L	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	135					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	CAATGTCCTTCAGATGGATTA	0.428													11	25					0	0	0	0	T	14758228	T	T	14758228	2	4	260	1	0	0	0	0	0	0	0	1	4488	813	29	2		2	DGKB	7	14758228	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08		14758228	144380435	56	47296											
ZNF804B	219578	broad.mit.edu	37	chr7	88963052	88963052	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgattgtaacaagtcaccCatttataaaacaaaacaaac	20	9	3	9	0	1	1	1	1	0	0	1	1	1	1	1	0	4	1	1	0	8	5	rs34688143		TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr7:88963052C>G	uc011khi.1	+	4	1294	c.756C>G	c.(754-756)CCC>CCG	p.P252P		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	252						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ACAAGTCACCCATTTATAAAA	0.343										HNSCC(36;0.09)			7	36					0	0	0	0	G	88963052	G	G	88963052	2	3	260	1	0	0	0	0	0	0	0	1	18238	581	21	4		4	ZNF804B	7	88963052	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	74204824	88963052	70175611	57	47297											
DOCK4	9732	broad.mit.edu	37	chr7	111368497	111368497	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaggtagcgggacggggcGccgcagagtccgctcgtaga	7	5	19	10	6	0	3	0	1	0	2	2	4	1	4	2	4	1	4	2	4	2	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr7:111368497G>A	uc003vfx.2	-	52	6003	c.5734C>T	c.(5734-5736)CGC>TGC	p.R1912C	DOCK4_uc011kml.1_Missense_Mutation_p.R793C|DOCK4_uc011kmm.1_Missense_Mutation_p.R781C|DOCK4_uc003vfw.2_Missense_Mutation_p.R1324C|DOCK4_uc003vfy.2_Missense_Mutation_p.R1957C|DOCK4_uc003vfv.2_Missense_Mutation_p.R225C	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1912	Pro-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				GGGACGGGGCGCCGCAGAGTC	0.716													13	34					0	0	0	0	A	111368497	A	A	111368497	3	1	260	1	0	0	0	0	1	0	0	0	4711	1087	38	1	170	1	DOCK4	7	111368497	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	22405445	111368497	47770166	58	47298											
PRSS1	5644	broad.mit.edu	37	chr7	142458445	142458445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgatgacaagatcgttggggGctacaactgtgaggagaatt	12	10	14	5	1	0	5	0	3	0	2	1	6	0	5	0	3	2	2	0	3	4	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr7:142458445G>A	uc003wak.2	+	2	97	c.80G>A	c.(79-81)GGC>GAC	p.G27D	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_Intron|PRSS1_uc003wam.2_5'Flank	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	27	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			ATCGTTGGGGGCTACAACTGT	0.537									Hereditary_Pancreatitis				21	153					0	0	0	0	A	142458445	A	A	142458445	3	1	260	1	0	0	0	0	1	0	0	0	12676	1203	42	4	86	4	PRSS1	7	142458445	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	31089948	142458445	16680218	59	47299											
TMEM176B	28959	broad.mit.edu	37	chr7	150490279	150490279	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagggaagacagggtctgagCgatcacacacagtgtcgatg	12	7	14	8	2	2	2	1	1	1	1	3	5	2	3	0	2	1	0	0	2	2	1	rs144557912		TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr7:150490279C>T	uc003wht.3	-	5	663	c.497G>A	c.(496-498)CGC>CAC	p.R166H	TMEM176B_uc003whu.3_Missense_Mutation_p.R166H|TMEM176B_uc003whv.3_Missense_Mutation_p.R129H|TMEM176B_uc003whw.3_Missense_Mutation_p.R166H	NM_001101313	NP_001094783	Q3YBM2	T176B_HUMAN	transmembrane protein 176B isoform a	166					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGGTCTGAGCGATCACACAC	0.507													11	48					0	0	0	0	T	150490279	T	T	150490279	3	4	260	1	0	0	0	0	1	0	0	0	16159	768	27	1	327	1	TMEM176B	7	150490279	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	8031834	150490279	8648384	60	47300											
NCOA2	10499	broad.mit.edu	37	chr8	71071826	71071826	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttcgtttgtgcagcaacAagagtgccatcagacaagga	12	9	10	10	1	2	2	1	0	1	2	3	3	2	3	1	1	4	3	1	1	3	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr8:71071826A>G	uc003xyn.1	-	10	1200	c.1038T>C	c.(1036-1038)CTT>CTC	p.L346L		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	346					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GTGCAGCAACAAGAGTGCCAT	0.408			T	RUNXBP2	AML								21	47					0	0	0	0	G	71071826	G	G	71071826	2	3	260	1	0	0	0	0	0	0	0	1	10283	117	5	5		5	NCOA2	8	71071826	Silent	SNP	A	TCGA-CV-7425-01A-11D-2078-08		71071826	75292196	61	47301											
INTS8	55656	broad.mit.edu	37	chr8	95866050	95866050	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagtgggaagtaccttctgtCtatagtggtgttatcctggg	7	15	13	6	0	2	0	0	0	2	0	3	1	3	1	2	3	1	2	2	3	6	6			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr8:95866050C>G	uc003yhb.2	+	14	1785	c.1659C>G	c.(1657-1659)GTC>GTG	p.V553V	INTS8_uc003yha.1_Silent_p.V553V|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Silent_p.V380V	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	553					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TACCTTCTGTCTATAGTGGTG	0.333													18	64					0	0	0	0	G	95866050	G	G	95866050	2	3	260	1	0	0	0	0	0	0	0	1	7823	900	32	2		2	INTS8	8	95866050	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	24794224	95866050	50497972	62	47302											
UBR5	51366	broad.mit.edu	37	chr8	103317373	103317373	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aactgatacacaagcatgcaAaatatttcgatttccatcac	16	11	4	10	1	1	1	1	1	0	0	3	2	2	1	1	0	4	2	1	0	6	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr8:103317373A>G	uc003ykr.1	-	21	2800	c.2767T>C	c.(2767-2769)TTG>CTG	p.L923L	UBR5_uc003yks.1_Silent_p.L923L	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	923					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CAAGCATGCAAAATATTTCGA	0.373													25	104					0	0	0	0	G	103317373	G	G	103317373	2	3	260	1	0	0	0	0	0	0	0	1	16973	11	1	5		5	UBR5	8	103317373	Silent	SNP	A	TCGA-CV-7425-01A-11D-2078-08	7451323	103317373	43046649	63	47303											
NAPRT1	93100	broad.mit.edu	37	chr8	144659308	144659308	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcccggccaccggcacacctCgcagctggcccgctagcacg	6	4	11	20	5	0	0	0	0	0	0	2	0	1	0	5	3	2	5	5	3	1	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr8:144659308C>T	uc003yym.3	-	5	633	c.608G>A	c.(607-609)CGA>CAA	p.R203Q	NAPRT1_uc003yyn.3_Missense_Mutation_p.R203Q|NAPRT1_uc011lkh.1_Missense_Mutation_p.R203Q|NAPRT1_uc003yyo.3_Missense_Mutation_p.R203Q	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	203					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CGGCACACCTCGCAGCTGGCC	0.677													6	20					0	0	0	0	T	144659308	T	T	144659308	3	4	260	1	0	0	0	0	1	0	0	0	10218	884	31	1	1044	1	NAPRT1	8	144659308	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	41341935	144659308	1704714	64	47304											
ZDHHC21	340481	broad.mit.edu	37	chr9	14674243	14674243	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaggaaagaggacaattttGggaattaaaacaatattgta	18	11	10	2	0	0	2	0	1	0	1	0	5	0	5	0	3	1	1	0	3	8	6			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr9:14674243G>T	uc003zli.2	-	4	566	c.96C>A	c.(94-96)CCC>CCA	p.P32P	ZDHHC21_uc003zlg.1_Intron	NM_178566	NP_848661	Q8IVQ6	ZDH21_HUMAN	zinc finger, DHHC-type containing 21	32	Helical; (Potential).				nitric oxide metabolic process|regulation of nitric-oxide synthase activity	Golgi membrane|integral to membrane	palmitoyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(50;4.31e-06)		GGACAATTTTGGGAATTAAAA	0.333													12	198					0.000151284	0.000160362	1	0	T	14674243	T	T	14674243	2	4	260	1	0	0	0	0	0	0	0	1	17679	1348	47	4		4	ZDHHC21	9	14674243	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08		14674243	126539188	65	47305											
FREM1	158326	broad.mit.edu	37	chr9	14740170	14740170	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccaaaaggactttctcccaCcaatgtcccagagccaccgc	11	7	6	17	1	1	1	0	0	1	1	4	2	3	2	6	1	1	0	6	1	3	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr9:14740170C>G	uc003zlm.2	-	36	6907	c.6317G>C	c.(6316-6318)GGT>GCT	p.G2106A	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_RNA|FREM1_uc003zll.2_Missense_Mutation_p.G642A	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	2106	C-type lectin.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CTTTCTCCCACCAATGTCCCA	0.502													11	162					0	0	0	0	G	14740170	G	G	14740170	3	3	260	1	0	0	0	0	1	0	0	0	6078	507	18	4	230	4	FREM1	9	14740170	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	65927	14740170	126473261	66	47306											
UNC13B	10497	broad.mit.edu	37	chr9	35310565	35310565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgaacaagatgacgaccatcGggagacggactcgattcatt	13	7	11	10	5	1	3	1	1	0	2	3	8	1	4	1	2	1	0	1	2	2	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr9:35310565G>A	uc003zwq.2	+	9	1155	c.863G>A	c.(862-864)CGG>CAG	p.R288Q	UNC13B_uc010mkl.1_Missense_Mutation_p.R288Q|UNC13B_uc003zwr.2_Missense_Mutation_p.R288Q	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	288					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GACGACCATCGGGAGACGGAC	0.517													40	218					0	0	0	0	A	35310565	A	A	35310565	3	1	260	1	0	0	0	0	1	0	0	0	17053	1116	39	1	897	1	UNC13B	9	35310565	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	20570395	35310565	105902866	67	47307											
TRPM3	80036	broad.mit.edu	37	chr9	73151732	73151732	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccagcccaaggatgttcaCggaattgtccagagggtcta	10	8	12	11	1	2	1	1	0	1	1	3	3	3	3	3	3	1	1	3	3	3	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr9:73151732C>A	uc004aid.2	-	25	4505	c.4261G>T	c.(4261-4263)GTG>TTG	p.V1421L	TRPM3_uc004ahu.2_Missense_Mutation_p.V1263L|TRPM3_uc004ahv.2_Missense_Mutation_p.V1223L|TRPM3_uc004ahw.2_Missense_Mutation_p.V1293L|TRPM3_uc004ahx.2_Missense_Mutation_p.V1280L|TRPM3_uc004ahy.2_Missense_Mutation_p.V1283L|TRPM3_uc004ahz.2_Missense_Mutation_p.V1270L|TRPM3_uc004aia.2_Missense_Mutation_p.V1268L|TRPM3_uc004aib.2_Missense_Mutation_p.V1258L|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1446	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AGGATGTTCACGGAATTGTCC	0.502													13	55					2.61681e-11	3.08203e-11	1	0	A	73151732	A	A	73151732	3	1	260	1	0	0	0	0	1	0	0	0	16654	536	19	3	866	3	TRPM3	9	73151732	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	37841167	73151732	68061699	68	47308											
DAB2IP	153090	broad.mit.edu	37	chr9	124522529	124522529	+	Frame_Shift_Del	DEL	G	-	-																															ggcaagggccctggacccatGatccgcatcaaggcgcgcta																										TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr9:124522529delG	uc004bln.2	+	6	966	c.897delG	c.(895-897)ATGfs	p.M299fs	DAB2IP_uc004blo.2_Frame_Shift_Del_p.M203fs	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	327					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						CTGGACCCATGATCCGCATCA	0.622													---	---	---								-	124522529	-	-	124522529	7	5	260	1	0	1	0	1	0	0	0	0	4236	1290	45	0	919	0	DAB2IP	9	124522529	Frame_Shift_Del	DEL	G	TCGA-CV-7425-01A-11D-2078-08	51370797	124522529	16690902	69	47309											
MAN1B1	11253	broad.mit.edu	37	chr9	139994165	139994165	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtgcatctgaactatcgcCagaagggcgtgattgacgtc	10	10	12	9	3	1	4	0	3	1	1	3	4	1	4	1	1	2	1	1	1	4	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr9:139994165C>T	uc004cld.2	+	6	783	c.748C>T	c.(748-750)CAG>TAG	p.Q250*	MAN1B1_uc004clc.2_Nonsense_Mutation_p.Q151*|MAN1B1_uc011meo.1_Nonsense_Mutation_p.Q151*|MAN1B1_uc011mep.1_Nonsense_Mutation_p.Q250*|MAN1B1_uc010ncc.2_RNA	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	250	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		GAACTATCGCCAGAAGGGCGT	0.582													50	49					0	0	0	0	T	139994165	T	T	139994165	4	4	260	1	0	0	0	0	0	1	0	0	9265	595	21	4	770	4	MAN1B1	9	139994165	Nonsense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	15471636	139994165	1219266	70	47310											
SORCS3	22986	broad.mit.edu	37	chr10	106937929	106937929	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaatggagacccacatcatGacgtgagtacttcttttgct	10	12	10	9	1	2	3	1	2	1	1	2	5	2	4	1	2	2	2	1	2	2	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr10:106937929G>T	uc001kyi.1	+	14	2234	c.2007G>T	c.(2005-2007)ATG>ATT	p.M669I	SORCS3_uc010qqz.1_Intron	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	669	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CCCACATCATGACGTGAGTAC	0.493													4	34					0.00024832	0.000259756	1	0	T	106937929	T	T	106937929	3	4	260	1	0	0	0	0	1	0	0	0	14996	1290	45	2	2061	2	SORCS3	10	106937929	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08		106937929	28596818	71	47311											
ABCC8	6833	broad.mit.edu	37	chr11	17428629	17428629	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggatctcagcacgctggtGcagcatggacgacaggttgt	8	9	15	9	2	1	0	1	0	1	0	2	3	1	2	0	4	3	5	0	4	0	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr11:17428629G>A	uc001mnc.2	-	25	3094	c.2968C>T	c.(2968-2970)CAC>TAC	p.H990Y		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	990	Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GCACGCTGGTGCAGCATGGAC	0.562													8	23					0	0	0	0	A	17428629	A	A	17428629	3	1	260	1	0	0	0	0	1	0	0	0	58	1319	46	4	1837	4	ABCC8	11	17428629	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08		17428629	117577887	72	47312											
CELF1	10658	broad.mit.edu	37	chr11	47504267	47504267	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctaaatactggggtccaaGagtatttagaccagcaaggt	13	10	11	7	0	0	2	0	0	0	2	1	2	1	2	2	3	3	3	2	3	7	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr11:47504267G>T	uc001nfl.2	-	6	677	c.667C>A	c.(667-669)CTT>ATT	p.L223I	CELF1_uc001nfm.2_Missense_Mutation_p.L223I|CELF1_uc001nfn.2_Missense_Mutation_p.L223I|CELF1_uc001nfo.1_Missense_Mutation_p.L249I|CELF1_uc010rhm.1_Missense_Mutation_p.L222I|CELF1_uc001nfp.2_Missense_Mutation_p.L250I|CELF1_uc001nfq.1_Missense_Mutation_p.L223I|CELF1_uc001nfr.1_Missense_Mutation_p.L223I	NM_001025596	NP_001020767	Q92879	CELF1_HUMAN	CUG triplet repeat, RNA-binding protein 1	223					embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|ovary(1)	3						TGGGGTCCAAGAGTATTTAGA	0.502													10	33					3.07112e-06	3.39103e-06	1	0	T	47504267	T	T	47504267	3	4	260	1	0	0	0	0	1	0	0	0	3230	942	33	2	824	2	CELF1	11	47504267	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	30075638	47504267	87502249	73	47313											
SLC3A2	6520	broad.mit.edu	37	chr11	62656109	62656109	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctcccctcttgagctggaaCgcctgaaactggagcctcac	8	8	10	15	1	2	2	1	2	1	0	3	4	3	4	4	2	4	2	4	2	2	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr11:62656109C>T	uc001nwd.2	+	12	2061	c.1837C>T	c.(1837-1839)CGC>TGC	p.R613C	SLC3A2_uc001nwb.2_Missense_Mutation_p.R644C|SLC3A2_uc001nwc.2_Missense_Mutation_p.R614C|SLC3A2_uc001nwe.2_Missense_Mutation_p.R582C|SLC3A2_uc001nwf.2_Missense_Mutation_p.R551C|SLC3A2_uc001nwg.2_Missense_Mutation_p.R512C	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	613	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						TGAGCTGGAACGCCTGAAACT	0.657													12	36					0	0	0	0	T	62656109	T	T	62656109	3	4	260	1	0	0	0	0	1	0	0	0	14691	536	19	1	1983	1	SLC3A2	11	62656109	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	15151842	62656109	72350407	74	47314											
SART1	9092	broad.mit.edu	37	chr11	65732031	65732031	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacccttggaggttaatgcCatcaagaagggtgagtatgg	13	9	13	6	0	1	2	1	1	0	1	1	3	1	3	2	4	2	2	2	4	5	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr11:65732031C>T	uc001ogl.2	+	3	509	c.417C>T	c.(415-417)GCC>GCT	p.A139A	SART1_uc010rot.1_5'UTR	NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	139					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1						AGGTTAATGCCATCAAGAAGG	0.517													5	51					0	0	0	0	T	65732031	T	T	65732031	2	4	260	1	0	0	0	0	0	0	0	1	13911	581	21	4		4	SART1	11	65732031	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	3075922	65732031	69274485	75	47315											
MTNR1B	4544	broad.mit.edu	37	chr11	92715442	92715442	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagagcccagctccaccCatcattggtgtgcagcacca	9	7	9	16	0	1	1	1	0	0	1	2	1	2	1	4	1	5	4	4	1	0	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr11:92715442C>T	uc001pdk.1	+	2	1156	c.1053C>T	c.(1051-1053)CCC>CCT	p.P351P		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	351	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CAGCTCCACCCATCATTGGTG	0.567													9	53					0	0	0	0	T	92715442	T	T	92715442	2	4	260	1	0	0	0	0	0	0	0	1	10005	581	21	4		4	MTNR1B	11	92715442	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	26983411	92715442	42291074	76	47316											
CASP4	837	broad.mit.edu	37	chr11	104820329	104820329	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccttcagactgaggcagttgCggttgttgaatatctggaag	9	12	13	7	1	2	3	1	2	1	1	2	4	2	4	1	3	1	4	1	3	3	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr11:104820329C>T	uc001pid.1	-	5	795	c.722G>A	c.(721-723)CGC>CAC	p.R241H	CASP4_uc001pib.1_Missense_Mutation_p.R185H|CASP4_uc009yxg.1_Missense_Mutation_p.R150H|CASP4_uc010rux.1_Missense_Mutation_p.R241H	NM_001225	NP_001216	P49662	CASP4_HUMAN	caspase 4 isoform alpha precursor	241					apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			lung(2)|ovary(1)|skin(1)	4		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		GAGGCAGTTGCGGTTGTTGAA	0.473													14	77					0	0	0	0	T	104820329	T	T	104820329	3	4	260	1	0	0	0	0	1	0	0	0	2685	768	27	1	427	1	CASP4	11	104820329	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	12104887	104820329	30186187	77	47317											
HTR3B	9177	broad.mit.edu	37	chr11	113803665	113803665	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgttgtttgcagtggaagaCgtagacctggcctttctgag	7	13	14	7	1	1	3	0	1	1	2	1	4	1	4	2	2	1	4	2	2	2	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-11A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	cf149007-ed33-4a5d-a925-193a5d670349	g.chr11:113803665C>T	uc001pok.2	+	6	613	c.546C>T	c.(544-546)GAC>GAT	p.D182D	HTR3B_uc001pol.2_Silent_p.D171D	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	182	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		CAGTGGAAGACGTAGACCTGG	0.463													3	51					0	0	0	0	T	113803665	T	T	113803665	2	4	260	1	0	0	0	0	0	0	0	1	7484	535	19	1		1	HTR3B	11	113803665	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	8983336	113803665	21202851	78	47318											
PANX3	116337	broad.mit.edu	37	chr11	124489330	124489330	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	acctccgccacttacctataCcttggtcatttccatctgga	8	13	5	15	1	2	0	1	0	1	0	4	1	4	1	6	2	2	0	6	2	3	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr11:124489330C>A	uc001qah.2	+	4	678	c.678C>A	c.(676-678)TAC>TAA	p.Y226*		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	226	Helical; (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CTTACCTATACCTTGGTCATT	0.507													3	23					6.4e-05	6.87568e-05	1	0	A	124489330	A	A	124489330	4	1	260	1	0	0	0	0	0	1	0	0	11476	518	18	4	692	4	PANX3	11	124489330	Nonsense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	10685665	124489330	10517186	79	47319											
PDE3A	5139	broad.mit.edu	37	chr12	20766410	20766410	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtattactgtggacatcgccGtcatgggcgaggcccacggc	7	8	14	12	4	1	0	1	0	0	0	2	2	1	1	2	4	1	1	2	4	2	2	rs150253039	byFrequency	TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr12:20766410G>A	uc001reh.1	+	3	1067	c.1045G>A	c.(1045-1047)GTC>ATC	p.V349I		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	349					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.V349I(1)		ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGACATCGCCGTCATGGGCGA	0.517													8	44					0	0	0	0	A	20766410	A	A	20766410	3	1	260	1	0	0	0	0	1	0	0	0	11691	1145	40	1	1055	1	PDE3A	12	20766410	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08		20766410	113085485	80	47320											
AQP6	363	broad.mit.edu	37	chr12	50369453	50369453	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtggagatggagagtgtgtGaaacagcctacgcctggccg	9	7	16	9	3	0	3	0	1	0	2	0	5	0	3	3	3	3	0	3	3	2	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr12:50369453G>A	uc001rvr.1	+	4	1185	c.848G>A	c.(847-849)TGA>TAA	p.*283*	AQP6_uc001rvp.1_Silent_p.*109*|AQP6_uc001rvq.1_RNA	NM_001652	NP_001643	Q13520	AQP6_HUMAN	aquaporin 6	283					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity				0						GAGAGTGTGTGAAACAGCCTA	0.672													4	12					0	0	0	0	A	50369453	A	A	50369453	2	1	260	1	0	0	0	0	0	0	0	1	830	1285	45	2		2	AQP6	12	50369453	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	29603043	50369453	83482442	81	47321											
SLC4A8	9498	broad.mit.edu	37	chr12	51855040	51855040	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggtcagcagtaccatgagAttggcagatccatggccacc	12	7	11	11	0	1	2	1	1	0	2	2	3	2	2	4	3	2	3	4	3	2	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr12:51855040A>T	uc001rys.1	+	9	1244	c.1066A>T	c.(1066-1068)ATT>TTT	p.I356F	SLC4A8_uc010sni.1_Missense_Mutation_p.I303F|SLC4A8_uc001rym.2_Missense_Mutation_p.I303F|SLC4A8_uc001ryn.2_Missense_Mutation_p.I303F|SLC4A8_uc001ryo.2_Missense_Mutation_p.I303F|SLC4A8_uc001ryp.1_Missense_Mutation_p.I303F|SLC4A8_uc010snj.1_Missense_Mutation_p.I383F|SLC4A8_uc001ryq.3_Missense_Mutation_p.I356F|SLC4A8_uc001ryr.2_Missense_Mutation_p.I356F|SLC4A8_uc010snk.1_Missense_Mutation_p.I303F	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	356	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		GTACCATGAGATTGGCAGATC	0.318													7	23					0	0	0	0	T	51855040	T	T	51855040	3	4	260	1	0	0	0	0	1	0	0	0	14723	333	12	5	1100	5	SLC4A8	12	51855040	Missense_Mutation	SNP	A	TCGA-CV-7425-01A-11D-2078-08	1485587	51855040	81996855	82	47322											
CSAD	51380	broad.mit.edu	37	chr12	53554091	53554091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcctgggacccatggcagcGcttgagcaggttctgtgtgg	5	9	17	10	1	1	1	0	1	1	0	1	2	1	2	2	5	2	4	2	5	0	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr12:53554091G>A	uc001sby.2	-	13	1105	c.979C>T	c.(979-981)CGC>TGC	p.R327C	CSAD_uc001sbw.2_Missense_Mutation_p.R180C|CSAD_uc009zmt.2_Missense_Mutation_p.R109C|CSAD_uc010snx.1_Missense_Mutation_p.R354C|CSAD_uc001sbz.2_Missense_Mutation_p.R327C|CSAD_uc009zmu.2_Missense_Mutation_p.R180C|CSAD_uc001sca.3_RNA	NM_015989	NP_057073	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	327					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			ovary(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CCATGGCAGCGCTTGAGCAGG	0.602									Hereditary_Prostate_Cancer				3	37					0	0	0	0	A	53554091	A	A	53554091	3	1	260	1	0	0	0	0	1	0	0	0	3940	1087	38	1	518	1	CSAD	12	53554091	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	1699051	53554091	80297804	83	47323											
KIF5A	3798	broad.mit.edu	37	chr12	57968891	57968891	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggagatcagtggggccatcGaggaggagttcactgtggcc	8	8	17	8	1	2	1	2	0	0	1	3	5	2	3	2	6	0	1	2	6	0	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr12:57968891G>A	uc001sor.1	+	16	1949	c.1741G>A	c.(1741-1743)GAG>AAG	p.E581K	KIF5A_uc010srr.1_Missense_Mutation_p.E492K	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	581					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						TGGGGCCATCGAGGAGGAGTT	0.527													4	19					0	0	0	0	A	57968891	A	A	57968891	3	1	260	1	0	0	0	0	1	0	0	0	8344	1059	37	1	1803	1	KIF5A	12	57968891	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	4414800	57968891	75883004	84	47324											
TRHDE	29953	broad.mit.edu	37	chr12	72969274	72969274	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taattggcctcaggttctttCtgtcagtaaccgagcgggct	7	13	11	10	2	4	0	2	0	2	0	4	1	4	0	2	3	2	3	2	3	2	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr12:72969274C>A	uc001sxa.2	+	12	2168	c.2138C>A	c.(2137-2139)TCT>TAT	p.S713Y		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	713	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CAGGTTCTTTCTGTCAGTAAC	0.403													14	30					3.27435e-08	3.74548e-08	1	0	A	72969274	A	A	72969274	3	1	260	1	0	0	0	0	1	0	0	0	16546	913	32	2	2184	2	TRHDE	12	72969274	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	15000383	72969274	60882621	85	47325											
OSBPL8	114882	broad.mit.edu	37	chr12	76763056	76763056	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttcaaactgtatcatatCattaagtgggtcccatggtc	10	16	7	8	0	3	0	3	0	0	0	5	0	4	0	1	2	1	1	1	2	4	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr12:76763056C>T	uc001sye.1	-	21	2746	c.2266G>A	c.(2266-2268)GAT>AAT	p.D756N	OSBPL8_uc001syf.1_Missense_Mutation_p.D714N|OSBPL8_uc001syg.1_Missense_Mutation_p.D714N	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	756					lipid transport		lipid binding			ovary(1)	1						TGTATCATATCATTAAGTGGG	0.303													8	42					0	0	0	0	T	76763056	T	T	76763056	3	4	260	1	0	0	0	0	1	0	0	0	11337	826	29	2	419	2	OSBPL8	12	76763056	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	3793782	76763056	57088839	86	47326											
PCDH17	27253	broad.mit.edu	37	chr13	58207860	58207860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtgtcgggtcctaggcGgaggagggacgggcggcggc	5	5	22	9	5	0	0	0	0	0	0	2	3	1	3	1	8	1	1	1	8	1	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr13:58207860G>A	uc001vhq.1	+	1	2072	c.1180G>A	c.(1180-1182)GGA>AGA	p.G394R	PCDH17_uc010aec.1_Missense_Mutation_p.G394R	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	394	Extracellular (Potential).|Gly-rich.|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GGTCCTAGGCGGAGGAGGGAc	0.527													4	6					0	0	0	0	A	58207860	A	A	58207860	3	1	260	1	0	0	0	0	1	0	0	0	11566	1117	39	1	1182	1	PCDH17	13	58207860	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08		58207860	56962018	87	47327											
PIBF1	10464	broad.mit.edu	37	chr13	73505317	73505317	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctagtgttcacttggcaaGaagagtgcttcaattagaaa	13	11	10	7	0	2	3	2	0	0	3	2	3	2	3	1	1	1	3	1	1	6	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr13:73505317G>A	uc001vjc.2	+	14	2050	c.1745G>A	c.(1744-1746)AGA>AAA	p.R582K	PIBF1_uc001vjb.2_Missense_Mutation_p.R582K|PIBF1_uc010aep.2_Missense_Mutation_p.R41K	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	582						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		CACTTGGCAAGAAGAGTGCTT	0.318													12	30					0	0	0	0	A	73505317	A	A	73505317	3	1	260	1	0	0	0	0	1	0	0	0	11934	942	33	2	1795	2	PIBF1	13	73505317	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	15297457	73505317	41664561	88	47328											
DUOX2	50506	broad.mit.edu	37	chr15	45388040	45388040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggcacctttgggtatccagCacagccattgccctttgggg	6	10	13	12	0	0	0	0	0	0	0	1	0	1	0	4	4	3	3	4	4	1	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr15:45388040C>T	uc010bea.2	-	30	4269	c.4066G>A	c.(4066-4068)GCT>ACT	p.A1356T	DUOX2_uc001zun.2_Missense_Mutation_p.A1356T	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	1356	Cytoplasmic (Potential).|FAD-binding FR-type.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		GGGTATCCAGCACAGCCATTG	0.622													12	10					0	0	0	0	T	45388040	T	T	45388040	3	4	260	1	0	0	0	0	1	0	0	0	4823	710	25	4	600	4	DUOX2	15	45388040	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08		45388040	57143352	89	47329											
NEDD4	4734	broad.mit.edu	37	chr15	56134138	56134138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaaaggtacttacgtagcaGaatattcaaacaacccataa	18	9	6	8	1	1	1	1	0	0	1	1	1	1	1	1	1	5	4	1	1	10	7			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr15:56134138G>A	uc002adj.2	-	15	3389	c.3089C>T	c.(3088-3090)TCT>TTT	p.S1030F	NEDD4_uc002adl.2_Missense_Mutation_p.S611F|NEDD4_uc002adi.2_Missense_Mutation_p.S958F|NEDD4_uc010ugj.1_Missense_Mutation_p.S1014F|NEDD4_uc010bfm.2_Missense_Mutation_p.S1013F|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1030	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		TTACGTAGCAGAATATTCAAA	0.303													28	28					0	0	0	0	A	56134138	A	A	56134138	3	1	260	1	0	0	0	0	1	0	0	0	10364	942	33	2	914	2	NEDD4	15	56134138	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	10746098	56134138	46397254	90	47330											
IQCH	64799	broad.mit.edu	37	chr15	67571827	67571827	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagacagcacagttcatctCtgcctgtctttccaagagca	12	10	7	12	0	3	2	1	0	2	2	5	2	4	2	2	0	3	3	2	0	2	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr15:67571827C>T	uc002aqo.1	+	4	411	c.364C>T	c.(364-366)CTG>TTG	p.L122L	IQCH_uc010ujv.1_5'UTR|IQCH_uc002aqn.1_Intron|IQCH_uc002aqq.1_Intron|IQCH_uc002aqp.1_Intron|IQCH_uc002aqm.2_Silent_p.L122L	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	122										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		CAGTTCATCTCTGCCTGTCTT	0.269													28	27					0	0	0	0	T	67571827	T	T	67571827	2	4	260	1	0	0	0	0	0	0	0	1	7850	912	32	2		2	IQCH	15	67571827	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	11437689	67571827	34959565	91	47331											
CHD2	1106	broad.mit.edu	37	chr15	93563370	93563370	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaccattatggggaccggCgacatatggatgcccaccgt	10	7	11	13	3	0	0	0	0	0	0	0	3	0	2	5	4	1	0	5	4	2	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr15:93563370C>T	uc002bsp.2	+	38	5610	c.5035C>T	c.(5035-5037)CGA>TGA	p.R1679*	CHD2_uc002bso.1_Nonsense_Mutation_p.R1679*	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1679					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TGGGGACCGGCGACATATGGA	0.547													12	17					0	0	0	0	T	93563370	T	T	93563370	4	4	260	1	0	0	0	0	0	1	0	0	3340	760	27	1	5185	1	CHD2	15	93563370	Nonsense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	25991543	93563370	8968022	92	47332											
MSLN	10232	broad.mit.edu	37	chr16	815614	815614	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccatcatccgcagcatcccGcaggtgagaccccaatcccc	9	5	7	20	2	1	1	1	1	0	1	4	2	4	1	7	1	1	3	7	1	1	0			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr16:815614G>A	uc002cjw.1	+	9	843	c.792G>A	c.(790-792)CCG>CCA	p.P264P	MSLN_uc002cjt.1_Silent_p.P264P|MSLN_uc002cju.1_Silent_p.P264P|MSLN_uc010brd.1_Silent_p.P263P|MSLN_uc002cjv.1_Silent_p.P264P|MSLN_uc002cjx.1_Silent_p.P264P|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	264	Required for megakaryocyte-potentiating factor activity.				cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				GCAGCATCCCGCAGGTGAGAC	0.706													5	15					0	0	0	0	A	815614	A	A	815614	2	1	260	1	0	0	0	0	0	0	0	1	9934	1074	38	1		1	MSLN	16	815614	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08		815614	89539139	93	47333											
CES1	1066	broad.mit.edu	37	chr16	55860122	55860122	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatattgaggtaaagacagtCttcagaaagcttgagaggaa	17	9	11	4	0	2	4	1	2	1	3	2	6	2	5	0	2	1	2	0	2	6	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr16:55860122C>T	uc002eim.2	-	3	451	c.343G>A	c.(343-345)GAC>AAC	p.D115N	CES1_uc002eil.2_Missense_Mutation_p.D116N|CES1_uc002ein.2_Missense_Mutation_p.D115N	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	115				D -> H (in Ref. 19; AAA83932).	response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	TAAAGACAGTCTTCAGAAAGC	0.512													27	103					0	0	0	0	T	55860122	T	T	55860122	3	4	260	1	0	0	0	0	1	0	0	0	3284	913	32	2	1408	2	CES1	16	55860122	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	55044508	55860122	34494631	94	47334											
CDH13	1012	broad.mit.edu	37	chr16	83813633	83813633	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctggaggacgtgaatgacaAtgccccgttcatttacccca	10	9	9	13	2	1	2	1	2	0	0	1	4	1	4	5	2	2	1	5	2	3	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr16:83813633A>G	uc002fgx.2	+	12	1862	c.1742A>G	c.(1741-1743)AAT>AGT	p.N581S	CDH13_uc010vns.1_Missense_Mutation_p.N628S|CDH13_uc010vnt.1_Missense_Mutation_p.N327S|CDH13_uc010vnu.1_Missense_Mutation_p.N542S	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	581	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GTGAATGACAATGCCCCGTTC	0.488													6	18					0	0	0	0	G	83813633	G	G	83813633	3	3	260	1	0	0	0	0	1	0	0	0	3114	101	4	5	1788	5	CDH13	16	83813633	Missense_Mutation	SNP	A	TCGA-CV-7425-01A-11D-2078-08	27953511	83813633	6541120	95	47335											
MYH4	4622	broad.mit.edu	37	chr17	10363395	10363395	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcgtagatggctttggcCagagcacccactgcattgta	8	12	10	11	1	1	2	0	0	1	2	2	2	1	2	2	2	2	5	2	2	2	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr17:10363395C>T	uc002gmn.2	-	14	1401	c.1290G>A	c.(1288-1290)CTG>CTA	p.L430L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	430	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TGGCTTTGGCCAGAGCACCCA	0.473													17	163					0	0	0	0	T	10363395	T	T	10363395	2	4	260	1	0	0	0	0	0	0	0	1	10090	581	21	4		4	MYH4	17	10363395	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08		10363395	70831815	96	47336											
ALDOC	230	broad.mit.edu	37	chr17	26902241	26902241	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	catggaagaaaatgacgcctCcaatgcactttttcacacgg	13	9	8	11	2	1	2	1	1	0	1	2	3	2	3	2	2	1	1	2	2	4	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr17:26902241C>G	uc002hbp.2	-	3	369	c.224G>C	c.(223-225)GGA>GCA	p.G75A	ALDOC_uc010cro.2_Missense_Mutation_p.G75A	NM_005165	NP_005156	P09972	ALDOC_HUMAN	fructose-bisphosphate aldolase C	75					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			ovary(1)	1	Lung NSC(42;0.00431)					AATGACGCCTCCAATGCACTT	0.527											OREG0024278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	24					0	0	0	0	G	26902241	G	G	26902241	3	3	260	1	0	0	0	0	1	0	0	0	509	855	30	2	898	2	ALDOC	17	26902241	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	16538846	26902241	54292969	97	47337											
ATAD5	79915	broad.mit.edu	37	chr17	29220528	29220528	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcttgctaggaaacactctGaaagagaacagccattgaaa	16	8	9	8	0	2	3	0	2	2	1	2	5	2	4	1	1	4	1	1	1	5	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr17:29220528G>C	uc002hfs.1	+	21	5003	c.4657G>C	c.(4657-4659)GAA>CAA	p.E1553Q		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1553					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GAAACACTCTGAAAGAGAACA	0.368													19	28					0	0	0	0	C	29220528	C	C	29220528	3	2	260	1	0	0	0	0	1	0	0	0	1078	1291	45	2	4739	2	ATAD5	17	29220528	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	2318287	29220528	51974682	98	47338											
UNC45B	146862	broad.mit.edu	37	chr17	33507656	33507656	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgatcagctgcggcaggcGgccaccgagtgcatgtgcaa	9	6	14	12	3	1	1	1	1	0	0	1	2	1	1	2	3	4	4	2	3	1	0			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr17:33507656G>A	uc002hja.2	+	18	2437	c.2340G>A	c.(2338-2340)GCG>GCA	p.A780A	UNC45B_uc002hjb.2_Silent_p.A778A|UNC45B_uc002hjc.2_Silent_p.A778A|UNC45B_uc010cto.2_Silent_p.A699A	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	780	ARM 3.				cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				TGCGGCAGGCGGCCACCGAGT	0.587													9	27					0	0	0	0	A	33507656	A	A	33507656	2	1	260	1	0	0	0	0	0	0	0	1	17057	1103	39	1		1	UNC45B	17	33507656	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	4287128	33507656	47687554	99	47339											
ERBB2	2064	broad.mit.edu	37	chr17	37883113	37883113	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttggacagcaccttctacCgctcactgctggaggacgat	8	9	10	14	2	2	0	1	0	1	0	2	4	2	3	3	3	3	3	3	3	1	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr17:37883113C>T	uc002hso.2	+	25	3254	c.3016C>T	c.(3016-3018)CGC>TGC	p.R1006C	ERBB2_uc002hsm.2_Missense_Mutation_p.R976C|ERBB2_uc010cwa.2_Missense_Mutation_p.R991C|ERBB2_uc002hsp.2_Missense_Mutation_p.R809C|ERBB2_uc010cwb.2_Missense_Mutation_p.R1006C|ERBB2_uc010wek.1_Missense_Mutation_p.R730C	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	1006	Cytoplasmic (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CACCTTCTACCGCTCACTGCT	0.637		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			14	58					0	0	0	0	T	37883113	T	T	37883113	3	4	260	1	0	0	0	0	1	0	0	0	5230	652	23	1	3114	1	ERBB2	17	37883113	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	4375457	37883113	43312097	100	47340											
L3MBTL4	91133	broad.mit.edu	37	chr18	6311562	6311562	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacatcttaccaagcgtccGtcctgatccaaacgctcttt	9	11	7	14	3	2	1	0	1	2	0	5	2	5	2	4	1	3	1	4	1	3	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr18:6311562G>A	uc002kmz.3	-	3	223	c.63C>T	c.(61-63)GAC>GAT	p.D21D	L3MBTL4_uc010dkt.2_Silent_p.D21D	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	21					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				CCAAGCGTCCGTCCTGATCCA	0.483													38	131					0	0	0	0	A	6311562	A	A	6311562	2	1	260	1	0	0	0	0	0	0	0	1	8634	1136	40	1		1	L3MBTL4	18	6311562	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08		6311562	71765686	101	47341											
POTEC	388468	broad.mit.edu	37	chr18	14534921	14534921	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttccatatctatcaagtgcaTttaaattagcttttttcttg	10	20	4	7	0	3	0	1	0	2	0	4	0	4	0	1	0	2	2	1	0	6	10			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr18:14534921T>A	uc010dln.2	-	4	1350	c.896A>T	c.(895-897)AAT>ATT	p.N299I	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	299	ANK 5.									skin(3)	3						ATCAAGTGCATTTAAATTAGC	0.303													6	54					0	0	0	0	A	14534921	A	A	14534921	3	1	260	1	0	0	0	0	1	0	0	0	12317	1493	52	5	764	5	POTEC	18	14534921	Missense_Mutation	SNP	T	TCGA-CV-7425-01A-11D-2078-08	8223359	14534921	63542327	102	47342											
DOK6	220164	broad.mit.edu	37	chr18	67266711	67266711	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catctttcacgatgaaacatCgaagacatttgcctgtgagt	12	12	8	9	2	2	3	1	2	1	1	3	5	2	3	1	0	2	0	1	0	2	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr18:67266711C>T	uc002lkl.2	+	3	456	c.266C>T	c.(265-267)TCG>TTG	p.S89L		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	89	PH.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GATGAAACATCGAAGACATTT	0.448													8	29					0	0	0	0	T	67266711	T	T	67266711	3	4	260	1	0	0	0	0	1	0	0	0	4723	893	31	1	276	1	DOK6	18	67266711	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	52731790	67266711	10810537	103	47343											
NETO1	81832	broad.mit.edu	37	chr18	70526309	70526309	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caatgcactgtcttggagcgGctgtaaagaagaaagattgt	13	10	12	6	1	1	3	0	0	1	3	1	4	1	4	0	2	2	3	0	2	5	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr18:70526309G>T	uc002lkw.2	-	4	505	c.221C>A	c.(220-222)GCC>GAC	p.A74D	NETO1_uc002lkx.1_Missense_Mutation_p.A73D|NETO1_uc002lky.1_Missense_Mutation_p.A74D|NETO1_uc002lkz.2_Missense_Mutation_p.A73D	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	74	CUB 1.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TCTTGGAGCGGCTGTAAAGAA	0.368													11	49					5.16669e-11	6.04046e-11	1	0	T	70526309	T	T	70526309	3	4	260	1	0	0	0	0	1	0	0	0	10393	1217	42	4	1417	4	NETO1	18	70526309	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	3259598	70526309	7550939	104	47344											
MUC16	94025	broad.mit.edu	37	chr19	9009703	9009703	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtgaacggcaccaggagaGgaacagctgctgtagtggga	11	5	18	7	1	0	2	0	1	0	1	0	5	0	4	1	5	4	4	1	5	3	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:9009703G>T	uc002mkp.2	-	39	39227	c.39023C>A	c.(39022-39024)CCT>CAT	p.P13008H	MUC16_uc010dwi.2_5'Flank|MUC16_uc010dwj.2_5'Flank|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13010	Extracellular (Potential).|SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CACCAGGAGAGGAACAGCTGC	0.453													5	59					5.9392e-07	6.6974e-07	1	0	T	9009703	T	T	9009703	3	4	260	1	0	0	0	0	1	0	0	0	10026	1000	35	4	4684	4	MUC16	19	9009703	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08		9009703	50119280	105	47345											
NR2C2AP	126382	broad.mit.edu	37	chr19	19313662	19313662	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atgtttttttccaaactgccGagtgttgcgattcagcactg	8	15	9	9	2	1	0	1	0	0	0	2	2	2	0	2	0	4	3	2	0	1	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:19313662G>C	uc002nlx.2	-	2	436	c.67C>G	c.(67-69)CGG>GGG	p.R23G	NR2C2AP_uc010xqq.1_5'Flank|NR2C2AP_uc002nly.2_Missense_Mutation_p.R23G	NM_176880	NP_795361	Q86WQ0	NR2CA_HUMAN	TR4 orphan receptor associated protein TRA16	23					cell adhesion|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm				ovary(1)	1			Epithelial(12;0.00235)			CCAAACTGCCGAGTGTTGCGA	0.577													12	41					0	0	0	0	C	19313662	C	C	19313662	3	2	260	1	0	0	0	0	1	0	0	0	10678	1057	37	3	368	3	NR2C2AP	19	19313662	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	10303959	19313662	39815321	106	47346											
ZNF536	9745	broad.mit.edu	37	chr19	30935483	30935483	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggccccaacggcggtggCgagcagtcggccaacgagtt	8	4	16	13	5	0	0	0	0	0	0	1	2	0	0	3	5	3	2	3	5	2	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:30935483C>A	uc002nsu.1	+	2	1152	c.1014C>A	c.(1012-1014)GGC>GGA	p.G338G	ZNF536_uc010edd.1_Silent_p.G338G	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					ACGGCGGTGGCGAGCAGTCGG	0.652													8	77					5.18039e-06	5.64166e-06	1	0	A	30935483	A	A	30935483	2	1	260	1	0	0	0	0	0	0	0	1	18041	755	27	3		3	ZNF536	19	30935483	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	11621821	30935483	28193500	107	47347											
WDR88	126248	broad.mit.edu	37	chr19	33623312	33623312	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgagaagcaccaggtgccGgagaaattgatctggggcga	11	6	15	9	2	1	3	0	2	1	2	1	6	1	3	3	4	2	1	3	4	2	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:33623312G>A	uc002nui.2	+	1	315	c.237G>A	c.(235-237)CCG>CCA	p.P79P		NM_173479	NP_775750	Q6ZMY6	WDR88_HUMAN	PQQ repeat and WD repeat domain containing	79										ovary(1)|breast(1)|central_nervous_system(1)	3	Esophageal squamous(110;0.137)					ACCAGGTGCCGGAGAAATTGA	0.657													12	43					0	0	0	0	A	33623312	A	A	33623312	2	1	260	1	0	0	0	0	0	0	0	1	17403	1103	39	1		1	WDR88	19	33623312	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	2687829	33623312	25505671	108	47348											
ATP4A	495	broad.mit.edu	37	chr19	36048663	36048663	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccttgataaggatggagctGcagcgctccagcacgcgctc	8	7	12	14	3	0	1	0	1	0	0	2	3	1	3	2	2	4	5	2	2	1	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:36048663G>T	uc002oal.1	-	11	1616	c.1587C>A	c.(1585-1587)TGC>TGA	p.C529*	ATP4A_uc010eee.1_5'UTR	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	529	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GGATGGAGCTGCAGCGCTCCA	0.652													4	11					1.024e-07	1.16297e-07	1	0	T	36048663	T	T	36048663	4	4	260	1	0	0	0	0	0	1	0	0	1147	1311	46	4	1568	4	ATP4A	19	36048663	Nonsense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	2425351	36048663	23080320	109	47349											
NTF4	4909	broad.mit.edu	37	chr19	49564712	49564712	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acacggccctgggcatcagcGgtcaatgcccgcacatagga	10	5	12	14	3	2	0	2	0	0	0	2	1	2	1	2	4	2	2	2	4	2	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:49564712G>A	uc002pmf.3	-	2	684	c.543C>T	c.(541-543)ACC>ACT	p.T181T	CGB7_uc010yah.1_Intron	NM_006179	NP_006170	P34130	NTF4_HUMAN	neurotrophin 5 preproprotein	181					adult locomotory behavior|epidermis development|ganglion mother cell fate determination|long-term memory|sensory organ boundary specification	endoplasmic reticulum lumen|extracellular region	growth factor activity				0		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		GGGCATCAGCGGTCAATGCCC	0.662													12	26					0	0	0	0	A	49564712	A	A	49564712	2	1	260	1	0	0	0	0	0	0	0	1	10751	1103	39	1		1	NTF4	19	49564712	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	13516049	49564712	9564271	110	47350											
CEACAM18	729767	broad.mit.edu	37	chr19	51981929	51981929	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agacccagatggagcctgtgGaggagggtcttcctcatggg	8	8	16	9	0	2	2	1	0	1	2	3	5	3	5	3	5	1	0	3	5	0	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:51981929G>T	uc002pwv.1	+	2	216	c.216G>T	c.(214-216)TGG>TGT	p.W72C		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	72						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GGAGCCTGTGGAGGAGGGTCT	0.632													6	16					5.18039e-06	5.64166e-06	1	0	T	51981929	T	T	51981929	3	4	260	1	0	0	0	0	1	0	0	0	3204	1183	41	2	222	2	CEACAM18	19	51981929	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	2417217	51981929	7147054	111	47351											
ZNF613	79898	broad.mit.edu	37	chr19	52443551	52443551	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaaggacctgtaccgagaCgtgatgttggagaactatag	13	8	13	7	2	0	4	0	1	0	3	0	7	0	5	2	2	2	2	2	2	5	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:52443551C>T	uc002pxz.1	+	4	528	c.105C>T	c.(103-105)GAC>GAT	p.D35D	ZNF613_uc002pya.1_Translation_Start_Site	NM_001031721	NP_001026891	Q6PF04	ZN613_HUMAN	zinc finger protein 613 isoform 1	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		TGTACCGAGACGTGATGTTGG	0.542													26	102					0	0	0	0	T	52443551	T	T	52443551	2	4	260	1	0	0	0	0	0	0	0	1	18105	535	19	1		1	ZNF613	19	52443551	Silent	SNP	C	TCGA-CV-7425-01A-11D-2078-08	461622	52443551	6685432	112	47352											
ZNF616	90317	broad.mit.edu	37	chr19	52619658	52619658	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtgtcttacaaaatatgaAttttttctgaagatcttgcc	11	17	7	6	0	3	3	0	2	3	1	3	3	3	3	1	1	2	0	1	1	6	6			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:52619658A>T	uc002pym.2	-	4	1042	c.759T>A	c.(757-759)AAT>AAA	p.N253K	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	253	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		CAAAATATGAATTTTTTCTGA	0.398													8	72					0	0	0	0	T	52619658	T	T	52619658	3	4	260	1	0	0	0	0	1	0	0	0	18108	98	4	5	1590	5	ZNF616	19	52619658	Missense_Mutation	SNP	A	TCGA-CV-7425-01A-11D-2078-08	176107	52619658	6509325	113	47353											
LILRA2	11027	broad.mit.edu	37	chr19	55087311	55087311	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctctctctcggtgcagccGgtccccacagtagccccagg	5	7	10	19	2	2	0	0	0	2	0	5	0	3	0	6	3	3	2	6	3	1	1	rs146068077	byFrequency	TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:55087311G>T	uc002qgg.3	+	6	1079	c.990G>T	c.(988-990)CCG>CCT	p.P330P	LILRA2_uc010ern.2_Silent_p.P330P|LILRA2_uc002qgf.2_Silent_p.P330P|LILRA2_uc010yfe.1_Silent_p.P330P|LILRA2_uc010yff.1_Silent_p.P318P|LILRA2_uc010ero.2_Silent_p.P318P|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	330	Ig-like C2-type 4.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CGGTGCAGCCGGTCCCCACAG	0.607													11	23					0.00010058	0.00010733	1	0	T	55087311	T	T	55087311	2	4	260	1	0	0	0	0	0	0	0	1	8826	1103	39	3		3	LILRA2	19	55087311	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	2467653	55087311	4041672	114	47354											
LILRB1	10859	broad.mit.edu	37	chr19	55146110	55146110	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggtctgggaaggcacctggGggttgtgatcggcatcttgg	6	10	18	7	1	2	1	0	1	2	0	3	2	2	2	1	7	0	3	1	7	1	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:55146110G>T	uc002qgj.2	+	11	1719	c.1379G>T	c.(1378-1380)GGG>GTG	p.G460V	LILRB1_uc010erp.1_Missense_Mutation_p.G75V|LILRB1_uc002qgl.2_Missense_Mutation_p.G460V|LILRB1_uc002qgk.2_Missense_Mutation_p.G461V|LILRB1_uc002qgm.2_Missense_Mutation_p.G461V|LILRB1_uc010erq.2_Missense_Mutation_p.G444V|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	460	Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		AGGCACCTGGGGGTTGTGATC	0.333										HNSCC(37;0.09)			4	17					0.00024832	0.000259756	1	0	T	55146110	T	T	55146110	3	4	260	1	0	0	0	0	1	0	0	0	8831	1232	43	4	1416	4	LILRB1	19	55146110	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	58799	55146110	3982873	115	47355											
NLRP7	199713	broad.mit.edu	37	chr19	55449436	55449436	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctttctgcagatgacaggtgCtacgggttacgtggtcacaa	9	11	12	9	2	2	2	1	1	1	1	2	2	2	2	0	3	4	3	0	3	3	3	rs139797510	byFrequency	TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr19:55449436C>T	uc002qih.3	-	5	2181	c.2105G>A	c.(2104-2106)AGC>AAC	p.S702N	NLRP7_uc002qig.3_Missense_Mutation_p.S674N|NLRP7_uc002qii.3_Missense_Mutation_p.S702N|NLRP7_uc010esk.2_Missense_Mutation_p.S702N|NLRP7_uc010esl.2_Missense_Mutation_p.S730N	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	702							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		ATGACAGGTGCTACGGGTTAC	0.398													52	171					0	0	0	0	T	55449436	T	T	55449436	3	4	260	1	0	0	0	0	1	0	0	0	10536	797	28	4	1036	4	NLRP7	19	55449436	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	303326	55449436	3679547	116	47356											
SLC4A11	83959	broad.mit.edu	37	chr20	3211199	3211199	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accaggctgaggttgaaaaaGgcataaagcgcaaggaagaa	18	4	13	6	1	0	3	0	2	0	1	0	4	0	4	1	4	1	4	1	4	7	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr20:3211199G>A	uc002wig.2	-	11	1473	c.1425C>T	c.(1423-1425)GCC>GCT	p.A475A	SLC4A11_uc010zqe.1_Silent_p.A502A|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Silent_p.A459A	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	475	Helical; (Potential).|Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						GGTTGAAAAAGGCATAAAGCG	0.532													16	57					0	0	0	0	A	3211199	A	A	3211199	2	1	260	1	0	0	0	0	0	0	0	1	14716	987	35	4		4	SLC4A11	20	3211199	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08		3211199	59814321	117	47357											
MCM8	84515	broad.mit.edu	37	chr20	5948561	5948561	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaaaggacagaaaacaaaGagttctgaggatgggtgtaa	18	6	13	4	0	1	3	0	1	1	2	1	5	1	5	0	3	2	3	0	3	5	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr20:5948561G>A	uc002wmi.2	+	10	1490	c.1113G>A	c.(1111-1113)AAG>AAA	p.K371K	MCM8_uc002wmj.2_Silent_p.K355K|MCM8_uc002wmk.2_Silent_p.K371K|MCM8_uc002wml.2_Silent_p.K371K|MCM8_uc010gbp.2_Silent_p.K371K|MCM8_uc002wmm.2_5'Flank	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	371					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						AGAAAACAAAGAGTTCTGAGG	0.343													19	36					0	0	0	0	A	5948561	A	A	5948561	2	1	260	1	0	0	0	0	0	0	0	1	9446	933	33	2		2	MCM8	20	5948561	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	2737362	5948561	57076959	118	47358											
C20orf103	24141	broad.mit.edu	37	chr20	9510385	9510385	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcatcatggtaacactcgCgatttaccacgtccaccaca	11	9	6	15	4	2	0	2	0	0	0	4	1	3	0	3	1	2	1	3	1	2	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr20:9510385C>T	uc002wni.1	+	6	990	c.761C>T	c.(760-762)GCG>GTG	p.A254V	C20orf103_uc010zrc.1_Missense_Mutation_p.A210V	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	254	Helical; (Potential).					integral to membrane		p.A254V(1)		upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			GTAACACTCGCGATTTACCAC	0.547													7	39					0	0	0	0	T	9510385	T	T	9510385	3	4	260	1	0	0	0	0	1	0	0	0	2085	768	27	1	783	1	C20orf103	20	9510385	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	3561824	9510385	53515135	119	47359											
ATP9A	10079	broad.mit.edu	37	chr20	50225128	50225128	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacatctttgtccaggaccaGagaaaacacaggaaacatgg	16	6	10	9	0	1	1	0	0	1	1	2	5	2	3	2	3	2	0	2	3	3	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr20:50225128G>C	uc002xwg.1	-	25	2674	c.2674C>G	c.(2674-2676)CTG>GTG	p.L892V	ATP9A_uc010gih.1_Missense_Mutation_p.L756V|ATP9A_uc002xwf.1_Missense_Mutation_p.L64V	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	892	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TCCAGGACCAGAGAAAACACA	0.448													10	31					0	0	0	0	C	50225128	C	C	50225128	3	2	260	1	0	0	0	0	1	0	0	0	1200	933	33	2	485	2	ATP9A	20	50225128	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	40714743	50225128	12800392	120	47360											
ITGB2	3689	broad.mit.edu	37	chr21	46320235	46320235	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcctggggtggggacttacGaattcgttgctcctcttgta	5	14	13	9	2	1	0	0	0	1	0	3	2	2	1	2	4	3	3	2	4	3	5	rs150327269		TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr21:46320235G>A	uc002zgd.2	-	6	941	c.897C>T	c.(895-897)TTC>TTT	p.F299F	ITGB2_uc002zge.2_Silent_p.F299F|ITGB2_uc002zgf.3_Silent_p.F299F|ITGB2_uc011afl.1_Silent_p.F221F|ITGB2_uc010gpw.2_Silent_p.F242F|ITGB2_uc002zgg.2_Silent_p.F299F	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	299	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GGGGACTTACGAATTCGTTGC	0.637													7	29					0	0	0	0	A	46320235	A	A	46320235	2	1	260	1	0	0	0	0	0	0	0	1	7933	1072	37	1		1	ITGB2	21	46320235	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08		46320235	1809660	121	47361											
TOP3B	8940	broad.mit.edu	37	chr22	22316888	22316888	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttctccagcatcttcacctCgcccacagggaaggcatcac	9	8	7	17	1	4	0	2	0	2	0	6	1	4	1	3	2	1	2	3	2	1	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr22:22316888C>T	uc002zvs.2	-	13	1873	c.1438G>A	c.(1438-1440)GAG>AAG	p.E480K	TOP3B_uc010gtm.1_Missense_Mutation_p.E25K|TOP3B_uc002zvr.2_Missense_Mutation_p.E205K|TOP3B_uc010gtl.2_Missense_Mutation_p.E480K|TOP3B_uc002zvt.3_Missense_Mutation_p.E480K	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	480					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		ATCTTCACCTCGCCCACAGGG	0.637													15	32					0	0	0	0	T	22316888	T	T	22316888	3	4	260	1	0	0	0	0	1	0	0	0	16435	893	31	1	1174	1	TOP3B	22	22316888	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08		22316888	28987678	122	47362											
PRAME	23532	broad.mit.edu	37	chr22	22890816	22890816	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agctgggagcagtggctcagGgaaggcaggagggcaaggag	11	3	21	6	0	1	0	1	0	0	0	1	4	1	4	0	7	2	5	0	7	2	0			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chr22:22890816G>A	uc002zwf.2	-	5	1359	c.1203C>T	c.(1201-1203)TCC>TCT	p.S401S	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Silent_p.S385S|PRAME_uc010gtr.2_Silent_p.S401S|PRAME_uc002zwg.2_Silent_p.S401S|PRAME_uc002zwh.2_Silent_p.S401S|PRAME_uc002zwi.2_Silent_p.S401S|PRAME_uc002zwj.2_Silent_p.S401S|PRAME_uc002zwk.2_Silent_p.S401S	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	401					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		AGTGGCTCAGGGAAGGCAGGA	0.572													8	47					0	0	0	0	A	22890816	A	A	22890816	2	1	260	1	0	0	0	0	0	0	0	1	12484	1219	43	4		4	PRAME	22	22890816	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	573928	22890816	28413750	123	47363											
FAM47B	170062	broad.mit.edu	37	chrX	34962243	34962243	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagcctaccaagaccggagCgtcccatctaaaagaactgt	13	6	10	12	2	1	2	0	0	1	2	2	4	2	4	4	2	4	0	4	2	5	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:34962243C>A	uc004ddi.1	+	1	1313	c.1295C>A	c.(1294-1296)GCG>GAG	p.A432E		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	432										ovary(3)|breast(1)	4						AAGACCGGAGCGTCCCATCTA	0.527													21	58					6.44725e-10	7.48258e-10	1	0	A	34962243	A	A	34962243	3	1	260	1	0	0	0	0	1	0	0	0	5602	768	27	3	1297	3	FAM47B	23	34962243	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08		34962243	120308317	124	47364											
SRPX	8406	broad.mit.edu	37	chrX	38009017	38009017	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggaccatctcttcttttcTcaagggaaaagtgtcaatca	12	13	7	9	0	5	0	3	0	3	0	7	2	5	2	1	2	0	0	1	2	5	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:38009017T>C	uc004ddy.1	-	10	1428	c.1342A>G	c.(1342-1344)AGA>GGA	p.R448G	SRPX_uc004ddz.1_Missense_Mutation_p.R428G|SRPX_uc011mkh.1_Missense_Mutation_p.R389G|SRPX_uc011mki.1_3'UTR	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	448					cell adhesion	cell surface|membrane					0						TCTTCTTTTCTCAAGGGAAAA	0.478													4	32					0	0	0	0	C	38009017	C	C	38009017	3	2	260	1	0	0	0	0	1	0	0	0	15230	1559	54	5	56	5	SRPX	23	38009017	Missense_Mutation	SNP	T	TCGA-CV-7425-01A-11D-2078-08	3046774	38009017	117261543	125	47365											
DGKK	139189	broad.mit.edu	37	chrX	50213157	50213157	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacatggtgctggacttggaCggaactctggagccgcctca	8	8	14	11	2	2	0	1	0	1	0	2	5	2	4	2	5	3	1	2	5	1	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:50213157C>T	uc010njr.1	-	1	581	c.521G>A	c.(520-522)CGT>CAT	p.R174H		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	174	33 X 4 AA approximate tandem repeats of E-P-A-P.|32.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TGGACTTGGACGGAACTCTGG	0.358													3	21					0	0	0	0	T	50213157	T	T	50213157	3	4	260	1	0	0	0	0	1	0	0	0	4494	536	19	1	3405	1	DGKK	23	50213157	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	12204140	50213157	105057403	126	47366											
HUWE1	10075	broad.mit.edu	37	chrX	53613475	53613475	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatctgggctctcctttttGaggagatggctgtcttttca	5	17	10	9	0	5	2	2	1	3	1	6	3	5	2	1	3	0	2	1	3	0	4			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:53613475G>C	uc004dsp.2	-	39	5201	c.4799C>G	c.(4798-4800)TCA>TGA	p.S1600*	HUWE1_uc004dsn.2_Nonsense_Mutation_p.S425*	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1600					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCTCCTTTTTGAGGAGATGGC	0.423													3	14					0	0	0	0	C	53613475	C	C	53613475	4	2	260	1	0	0	0	0	0	1	0	0	7500	1294	45	2	8509	2	HUWE1	23	53613475	Nonsense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	3400318	53613475	101657085	127	47367											
HUWE1	10075	broad.mit.edu	37	chrX	53620464	53620464	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaccagcataagccaggCatctaggaattctcctgtgc	10	9	8	14	0	2	0	0	0	2	0	4	1	3	1	4	2	3	2	4	2	3	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:53620464C>T	uc004dsp.2	-	32	4003	c.3601G>A	c.(3601-3603)GCC>ACC	p.A1201T	HUWE1_uc004dsn.2_Missense_Mutation_p.A26T	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1201					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						ATAAGCCAGGCATCTAGGAAT	0.507													3	27					0	0	0	0	T	53620464	T	T	53620464	3	4	260	1	0	0	0	0	1	0	0	0	7500	710	25	4	9735	4	HUWE1	23	53620464	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	6989	53620464	101650096	128	47368											
USP51	158880	broad.mit.edu	37	chrX	55513554	55513554	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gataaaggtattaatctttcGcctctgtttgcctacatgct	9	16	7	9	1	2	0	0	0	2	0	3	1	2	0	2	1	3	3	2	1	5	6			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:55513554G>A	uc004dun.1	-	2	1898	c.1819C>T	c.(1819-1821)CGA>TGA	p.R607*	USP51_uc011moo.1_Nonsense_Mutation_p.R311*	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	607					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						TTAATCTTTCGCCTCTGTTTG	0.443													3	45					0	0	0	0	A	55513554	A	A	55513554	4	1	260	1	0	0	0	0	0	1	0	0	17151	1095	38	1	320	1	USP51	23	55513554	Nonsense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	1893090	55513554	99757006	129	47369											
UPRT	139596	broad.mit.edu	37	chrX	74494381	74494381	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctggcaactccttcctaGaggactgcgaactctcccgg	8	8	10	15	2	1	1	0	0	1	1	4	3	3	2	3	3	4	2	3	3	3	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:74494381G>C	uc004ecb.1	+	1	421	c.292G>C	c.(292-294)GAG>CAG	p.E98Q	UPRT_uc010nlu.1_Missense_Mutation_p.E98Q|UPRT_uc004ecc.1_RNA|UPRT_uc004ecd.1_Missense_Mutation_p.E98Q|UPRT_uc004ece.1_5'Flank	NM_145052	NP_659489	Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog	98					nucleoside metabolic process	cytoplasm|nucleus					0						CTCCTTCCTAGAGGACTGCGA	0.582													2	18					0	0	0	0	C	74494381	C	C	74494381	3	2	260	1	0	0	0	0	1	0	0	0	17082	943	33	2	294	2	UPRT	23	74494381	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	18980827	74494381	80776179	130	47370											
ZDHHC15	158866	broad.mit.edu	37	chrX	74742782	74742782	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcacgacgaggacaataacGagcactggcacccaggacag	15	2	12	12	3	0	0	0	0	0	0	0	5	0	2	1	3	3	3	1	3	2	1			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:74742782G>A	uc004ecg.2	-	1	556	c.78C>T	c.(76-78)CTC>CTT	p.L26L	ZDHHC15_uc004ech.2_Silent_p.L26L|ZDHHC15_uc011mqo.1_RNA|ZDHHC15_uc004eci.2_Silent_p.L26L	NM_144969	NP_659406	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15 isoform 1	26	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(2)	2						GGACAATAACGAGCACTGGCA	0.587													4	31					0	0	0	0	A	74742782	A	A	74742782	2	1	260	1	0	0	0	0	0	0	0	1	17672	1045	37	1		1	ZDHHC15	23	74742782	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	248401	74742782	80527778	131	47371											
ATP7A	538	broad.mit.edu	37	chrX	77245124	77245124	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatccctgagaaaagcaataGaggctgtatcaccggggcta	14	7	11	9	1	1	2	1	1	0	2	2	3	2	2	2	3	1	4	2	3	7	3			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:77245124G>A	uc004ecx.3	+	4	1166	c.1006G>A	c.(1006-1008)GAG>AAG	p.E336K	ATP7A_uc004ecw.2_Missense_Mutation_p.E336K	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	336	HMA 3.|Cytoplasmic (Potential).			E -> V (in Ref. 1; AAA35580 and 8; AAA96010).	ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						AAAAGCAATAGAGGCTGTATC	0.418													78	131					0	0	0	0	A	77245124	A	A	77245124	3	1	260	1	0	0	0	0	1	0	0	0	1192	943	33	2	1016	2	ATP7A	23	77245124	Missense_Mutation	SNP	G	TCGA-CV-7425-01A-11D-2078-08	2502342	77245124	78025436	132	47372											
NXF3	56000	broad.mit.edu	37	chrX	102337277	102337277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctttccacttgtccatctCccctgcagacatcacctgca	7	11	4	19	0	2	1	1	0	1	1	5	1	4	1	6	0	2	2	6	0	0	2			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:102337277C>T	uc004eju.2	-	9	867	c.796G>A	c.(796-798)GAG>AAG	p.E266K	NXF3_uc010noi.1_Missense_Mutation_p.E116K|NXF3_uc011mrw.1_Missense_Mutation_p.E266K|NXF3_uc011mrx.1_Missense_Mutation_p.E177K	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	266						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						TTGTCCATCTCCCCTGCAGAC	0.542													13	112					0	0	0	0	T	102337277	T	T	102337277	3	4	260	1	0	0	0	0	1	0	0	0	10839	864	30	2	843	2	NXF3	23	102337277	Missense_Mutation	SNP	C	TCGA-CV-7425-01A-11D-2078-08	25092153	102337277	52933283	133	47373											
BCORL1	63035	broad.mit.edu	37	chrX	129149172	129149172	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctctttgtggaaacccacGgggccggcaaatatttatcc	9	11	9	12	2	1	0	0	0	1	0	3	1	2	1	3	4	1	1	3	4	4	4	rs138691600	byFrequency	TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:129149172G>A	uc004evb.1	+	4	2538	c.2424G>A	c.(2422-2424)ACG>ACA	p.T808T	BCORL1_uc010nrd.1_Silent_p.T710T	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	808					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						GGAAACCCACGGGGCCGGCAA	0.587													9	71					0	0	0	0	A	129149172	A	A	129149172	2	1	260	1	0	0	0	0	0	0	0	1	1389	1103	39	1		1	BCORL1	23	129149172	Silent	SNP	G	TCGA-CV-7425-01A-11D-2078-08	26811895	129149172	26121388	134	47374											
SLITRK2	84631	broad.mit.edu	37	chrX	144904556	144904556	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgctggcgtccttgaacatAttggagggatcatggagatt	9	13	13	6	1	1	2	1	1	0	1	2	5	2	4	1	4	2	1	1	4	2	5			TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:144904556A>T	uc004fcd.2	+	5	1603	c.613A>T	c.(613-615)ATT>TTT	p.I205F	SLITRK2_uc010nsp.2_Missense_Mutation_p.I205F|SLITRK2_uc010nso.2_Missense_Mutation_p.I205F|SLITRK2_uc011mwq.1_Missense_Mutation_p.I205F|SLITRK2_uc011mwr.1_Missense_Mutation_p.I205F|SLITRK2_uc011mws.1_Missense_Mutation_p.I205F|SLITRK2_uc004fcg.2_Missense_Mutation_p.I205F|SLITRK2_uc011mwt.1_Missense_Mutation_p.I205F	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	205	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CCTTGAACATATTGGAGGGAT	0.473													19	128					0	0	0	0	T	144904556	T	T	144904556	3	4	260	1	0	0	0	0	1	0	0	0	14807	449	16	5	615	5	SLITRK2	23	144904556	Missense_Mutation	SNP	A	TCGA-CV-7425-01A-11D-2078-08	15755384	144904556	10366004	135	47375											
GABRE	2564	broad.mit.edu	37	chrX	151138747	151138752	+	In_Frame_Del	DEL	CAGTCT	-	-																															cagtttgccaactctgctccCagtctcagtctcagttgact																										TCGA-CV-7425-01A-11D-2078-08	TCGA-CV-7425-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8cc6696-91d0-4eba-a765-ef7d044238ce	dabfb4d4-709e-497b-904c-d91d22ec5b55	g.chrX:151138747_151138752delCAGTCT	uc004ffi.2	-	2	233_238	c.179_184delAGACTG	c.(178-186)GAGACTGGG>GGG	p.ET60del	GABRE_uc011myd.1_RNA|GABRE_uc011mye.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	60_61	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ACTCTGCTCCCAGTCTCAGTCTCAGT	0.519													---	---	---								-	151138752	-	-	151138747	7	5	260	1	0	1	0	1	0	0	0	0	6204	594	21	0	1368	0	GABRE	23	151138747	In_Frame_Del	DEL	CAGTCT	TCGA-CV-7425-01A-11D-2078-08	6234191	151138747	4131813	136	47376											
TNFRSF4	7293	broad.mit.edu	37	chr1	1147457	1147457	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctggggggtccctgtcctCacagattgcgtccgagctat	5	10	14	12	2	1	1	1	0	0	1	4	2	4	1	3	4	2	2	3	4	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:1147457C>A	uc001ade.2	-	5	504	c.499G>T	c.(499-501)GAG>TAG	p.E167*	TNFRSF4_uc001adf.2_Nonsense_Mutation_p.E171*	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	167	TNFR-Cys 4.|Extracellular (Potential).				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TCCCTGTCCTCACAGATTGCG	0.662													6	18					0.00198382	0.00203089	1	0	A	1147457	A	A	1147457	4	1	261	1	0	0	0	0	0	1	0	0	16363	835	29	2	346	2	TNFRSF4	1	1147457	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08		1147457	248103164	1	47377											
CCDC27	148870	broad.mit.edu	37	chr1	3679939	3679939	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctccctggccgagtcgtttGaggaggagctgctggcccag	5	8	15	13	2	0	1	0	1	0	0	2	4	1	3	4	4	2	3	4	4	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:3679939G>A	uc001akv.2	+	7	1303	c.1222G>A	c.(1222-1224)GAG>AAG	p.E408K		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	408	Glu-rich.									skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CGAGTCGTTTGAGGAGGAGCT	0.428													4	26					0	0	0	0	A	3679939	A	A	3679939	3	1	261	1	0	0	0	0	1	0	0	0	2814	1291	45	2	1248	2	CCDC27	1	3679939	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2532482	3679939	245570682	2	47378											
CLSTN1	22883	broad.mit.edu	37	chr1	9795145	9795145	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaaaatggtggacgccactCaggctgatcttgggctcctc	8	9	12	12	1	2	1	1	1	1	0	4	2	3	2	2	4	0	3	2	4	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:9795145C>G	uc001aqh.2	-	14	2730	c.1971G>C	c.(1969-1971)CTG>CTC	p.L657L	CLSTN1_uc001aqi.2_Silent_p.L647L|CLSTN1_uc010oag.1_Silent_p.L638L|CLSTN1_uc001aqf.2_5'Flank	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	calsyntenin 1 isoform 1	657	Extracellular (Potential).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		GGACGCCACTCAGGCTGATCT	0.542													29	112					0	0	0	0	G	9795145	G	G	9795145	2	3	261	1	0	0	0	0	0	0	0	1	3576	813	29	2		2	CLSTN1	1	9795145	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	6115206	9795145	239455476	3	47379											
TARDBP	23435	broad.mit.edu	37	chr1	11077026	11077026	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaccgaacaggacctgaaaGagtattttagtacctttgga	14	10	9	8	1	0	2	0	1	0	1	0	5	0	4	3	2	3	2	3	2	6	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:11077026G>A	uc001art.2	+	3	498	c.364G>A	c.(364-366)GAG>AAG	p.E122K	TARDBP_uc010oap.1_Intron	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	122	RRM 1.			Missing: Completely abolishes RNA binding.	3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		GGACCTGAAAGAGTATTTTAG	0.383													21	78					0	0	0	0	A	11077026	A	A	11077026	3	1	261	1	0	0	0	0	1	0	0	0	15623	943	33	2	370	2	TARDBP	1	11077026	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1281881	11077026	238173595	4	47380											
C1orf158	93190	broad.mit.edu	37	chr1	12819396	12819396	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaagttgctgtggctgccaGagaagtctgactttcccctt	8	12	11	10	0	1	3	0	1	1	2	2	4	2	3	3	1	2	3	3	1	2	3	rs148059585		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:12819396G>C	uc001auh.2	+	3	595	c.379G>C	c.(379-381)GAG>CAG	p.E127Q	C1orf158_uc010obe.1_Missense_Mutation_p.E127Q	NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	127										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGCTGCCAGAGAAGTCTGA	0.522													13	50					0	0	0	0	C	12819396	C	C	12819396	3	2	261	1	0	0	0	0	1	0	0	0	2016	943	33	2	389	2	C1orf158	1	12819396	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1742370	12819396	236431225	5	47381											
PRAMEF12	390999	broad.mit.edu	37	chr1	12837643	12837643	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcccaagattattgtgttCagcactgtcccctgccctcg	7	11	8	15	1	1	1	1	0	0	1	3	1	2	1	4	0	3	2	4	0	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:12837643C>T	uc001aui.2	+	3	1380	c.1353C>T	c.(1351-1353)TTC>TTT	p.F451F		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	451										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTATTGTGTTCAGCACTGTCC	0.527													25	73					0	0	0	0	T	12837643	T	T	12837643	2	4	261	1	0	0	0	0	0	0	0	1	12488	825	29	2		2	PRAMEF12	1	12837643	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	18247	12837643	236412978	6	47382											
AGMAT	79814	broad.mit.edu	37	chr1	15904338	15904338	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgacttcatccagcagtcttCagccaggactacccggaagc	10	7	9	15	2	3	0	2	0	1	0	4	3	4	2	3	2	4	1	3	2	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:15904338C>T	uc001awv.1	-	5	885	c.742G>A	c.(742-744)GAA>AAA	p.E248K	DNAJC16_uc001awu.2_Intron	NM_024758	NP_079034	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase) precursor	248					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			skin(1)	1		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		CAGCAGTCTTCAGCCAGGACT	0.413													7	19					0	0	0	0	T	15904338	T	T	15904338	3	4	261	1	0	0	0	0	1	0	0	0	385	835	29	2	328	2	AGMAT	1	15904338	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3066695	15904338	233346283	7	47383											
UBR4	23352	broad.mit.edu	37	chr1	19478158	19478158	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagaggttcagcttcttatCagcctgcagggcttcttctc	7	13	10	11	0	5	1	2	0	3	1	6	2	5	1	1	2	3	4	1	2	2	5	rs55848569		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:19478158C>T	uc001bbi.2	-	48	7196	c.7192G>A	c.(7192-7194)GAT>AAT	p.D2398N	UBR4_uc001bbk.1_Missense_Mutation_p.D52N|UBR4_uc001bbl.1_Missense_Mutation_p.D335N|UBR4_uc001bbm.1_Missense_Mutation_p.D1610N	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2398					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGCTTCTTATCAGCCTGCAGG	0.537													21	54					0	0	0	0	T	19478158	T	T	19478158	3	4	261	1	0	0	0	0	1	0	0	0	16972	826	29	2	8595	2	UBR4	1	19478158	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3573820	19478158	229772463	8	47384											
PLA2G2F	64600	broad.mit.edu	37	chr1	20474786	20474786	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgagaggagtaccgtggcttCctcaatgtctactgccaggg	8	9	13	11	2	2	1	1	0	1	1	3	3	3	2	3	3	3	2	3	3	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:20474786C>T	uc009vpp.1	+	5	626	c.528C>T	c.(526-528)TTC>TTT	p.F176F		NM_022819	NP_073730	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	133					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		ACCGTGGCTTCCTCAATGTCT	0.582													8	44					0	0	0	0	T	20474786	T	T	20474786	2	4	261	1	0	0	0	0	0	0	0	1	12054	854	30	2		2	PLA2G2F	1	20474786	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	996628	20474786	228775835	9	47385											
WNT4	54361	broad.mit.edu	37	chr1	22456196	22456196	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaactggtactggcactcctCaatggccagctgggcaccgc	8	7	12	14	1	1	0	1	0	0	0	2	1	2	0	3	4	3	4	3	4	3	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:22456196C>G	uc001bfs.3	-	2	330	c.226G>C	c.(226-228)GAG>CAG	p.E76Q	WNT4_uc010odt.1_Missense_Mutation_p.E13Q	NM_030761	NP_110388	P56705	WNT4_HUMAN	wingless-type MMTV integration site family,	76					adrenal gland development|androgen biosynthetic process|anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|dermatome development|endoderm development|epithelial to mesenchymal transition|establishment of protein localization in plasma membrane|female gonad development|female sex determination|liver development|male gonad development|mesonephric tubule development|metanephric mesenchymal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of male gonad development|negative regulation of testicular blood vessel morphogenesis|negative regulation of testosterone biosynthetic process|negative regulation of transcription, DNA-dependent|oocyte development|paramesonephric duct development|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of collagen biosynthetic process|positive regulation of cortisol biosynthetic process|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|protein palmitoylation|renal vesicle formation|smooth muscle cell differentiation|somatotropin secreting cell differentiation|tertiary branching involved in mammary gland duct morphogenesis|thyroid-stimulating hormone-secreting cell differentiation|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|extracellular space|Golgi apparatus|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|signal transducer activity|transcription corepressor activity			ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;9.02e-26)|Colorectal(126;1.71e-07)|COAD - Colon adenocarcinoma(152;1.17e-05)|GBM - Glioblastoma multiforme(114;2.01e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000568)|KIRC - Kidney renal clear cell carcinoma(1967;0.00277)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		TGGCACTCCTCAATGGCCAGC	0.627													14	40					0	0	0	0	G	22456196	G	G	22456196	3	3	261	1	0	0	0	0	1	0	0	0	17458	835	29	2	845	2	WNT4	1	22456196	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1981410	22456196	226794425	10	47386											
FGR	2268	broad.mit.edu	37	chr1	27942093	27942093	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcccggcttcagcgtcttCaccgccaccttagtgctgcc	4	10	10	17	3	3	0	2	0	1	0	3	0	3	0	5	1	4	2	5	1	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:27942093C>T	uc001boj.2	-	7	1016	c.870G>A	c.(868-870)GTG>GTA	p.V290V	FGR_uc001boi.2_5'UTR|FGR_uc001bok.2_Silent_p.V290V|FGR_uc001bol.2_Silent_p.V290V|FGR_uc001bom.2_Silent_p.V290V	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	290	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCAGCGTCTTCACCGCCACCT	0.682													8	23					0	0	0	0	T	27942093	T	T	27942093	2	4	261	1	0	0	0	0	0	0	0	1	5906	813	29	2		2	FGR	1	27942093	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5485897	27942093	221308528	11	47387											
PHACTR4	65979	broad.mit.edu	37	chr1	28793131	28793131	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagactgttaatctctctgtCaccccttccccagcacccag	9	10	5	17	0	3	1	1	0	2	1	5	1	4	1	5	0	1	2	5	0	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:28793131C>T	uc001bpw.2	+	6	957	c.675C>T	c.(673-675)GTC>GTT	p.V225V	PHACTR4_uc001bpu.2_Silent_p.V225V|PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Silent_p.V209V|PHACTR4_uc001bpy.2_Silent_p.V235V	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	225							actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		ATCTCTCTGTCACCCCTTCCC	0.597													11	36					0	0	0	0	T	28793131	T	T	28793131	2	4	261	1	0	0	0	0	0	0	0	1	11867	813	29	2		2	PHACTR4	1	28793131	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	851038	28793131	220457490	12	47388											
KPNA6	23633	broad.mit.edu	37	chr1	32632895	32632895	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaggaacccctgagcagatCaggtattacattcctttccc	10	10	9	12	0	1	2	1	1	0	1	3	4	3	4	4	3	3	2	4	3	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:32632895C>G	uc001bug.2	+	12	1330	c.1242C>G	c.(1240-1242)ATC>ATG	p.I414M	KPNA6_uc001buh.2_Missense_Mutation_p.I189M|KPNA6_uc010ogx.1_Missense_Mutation_p.I411M|KPNA6_uc010ogy.1_Missense_Mutation_p.I419M|KPNA6_uc009vtz.2_Missense_Mutation_p.I309M	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	414	ARM 9.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CTGAGCAGATCAGGTATTACA	0.473													22	79					0	0	0	0	G	32632895	G	G	32632895	3	3	261	1	0	0	0	0	1	0	0	0	8473	816	29	2	1288	2	KPNA6	1	32632895	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3839764	32632895	216617726	13	47389											
YARS	8565	broad.mit.edu	37	chr1	33263435	33263435	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctacttttaaatactcttCatccaaagcctgtggaaaga	14	13	5	9	0	3	1	1	0	2	1	4	2	4	2	2	1	3	0	2	1	6	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:33263435C>T	uc001bvy.1	-	5	1308	c.520G>A	c.(520-522)GAA>AAA	p.E174K		NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	174					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	AAATACTCTTCATCCAAAGCC	0.274													13	31					0	0	0	0	T	33263435	T	T	33263435	3	4	261	1	0	0	0	0	1	0	0	0	17535	835	29	2	1102	2	YARS	1	33263435	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	630540	33263435	215987186	14	47390											
ZC3H12A	80149	broad.mit.edu	37	chr1	37941518	37941518	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acctgagaccagtggtcatcGatgggagcaacgtggccatg	10	7	14	10	2	1	1	1	1	0	1	2	4	1	2	3	3	2	1	3	3	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:37941518G>C	uc001cbb.3	+	2	571	c.421G>C	c.(421-423)GAT>CAT	p.D141H		NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	141					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGTGGTCATCGATGGGAGCAA	0.592													5	8					0	0	0	0	C	37941518	C	C	37941518	3	2	261	1	0	0	0	0	1	0	0	0	17628	1058	37	3	423	3	ZC3H12A	1	37941518	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4678083	37941518	211309103	15	47391											
GNL2	29889	broad.mit.edu	37	chr1	38040301	38040301	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtccggaaagcgagcttctCaagaaagtcctcagcattct	12	9	9	11	2	3	1	2	0	2	1	6	3	5	2	2	1	3	2	2	1	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:38040301C>G	uc001cbk.2	-	11	1430	c.1267G>C	c.(1267-1269)GAG>CAG	p.E423Q		NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	423					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				GCGAGCTTCTCAAGAAAGTCC	0.428													18	28					0	0	0	0	G	38040301	G	G	38040301	3	3	261	1	0	0	0	0	1	0	0	0	6573	835	29	2	952	2	GNL2	1	38040301	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	98783	38040301	211210320	16	47392											
MTF1	4520	broad.mit.edu	37	chr1	38323027	38323027	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttattgtcaaatgaatctGatctggtgagataatgtgct	11	16	10	4	0	3	3	1	3	2	1	3	4	3	3	0	1	1	2	0	1	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:38323027G>C	uc001cce.1	-	2	445	c.304C>G	c.(304-306)CAG>GAG	p.Q102E	MTF1_uc009vvj.1_Translation_Start_Site	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	102						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AAATGAATCTGATCTGGTGAG	0.453													19	63					0	0	0	0	C	38323027	C	C	38323027	3	2	261	1	0	0	0	0	1	0	0	0	9975	1299	45	2	1997	2	MTF1	1	38323027	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	282726	38323027	210927594	17	47393											
EBNA1BP2	10969	broad.mit.edu	37	chr1	43630388	43630388	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccggaagctagatacatcatCatagctctcccgagtgttcc	10	10	8	13	2	3	1	2	0	1	1	5	3	4	2	3	1	3	3	3	1	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:43630388C>T	uc001cin.2	-	8	993	c.796G>A	c.(796-798)GAT>AAT	p.D266N	EBNA1BP2_uc001cio.2_Missense_Mutation_p.D321N|EBNA1BP2_uc001cim.2_Missense_Mutation_p.D161N|EBNA1BP2_uc010ojx.1_Missense_Mutation_p.D321N	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	266					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GATACATCATCATAGCTCTCC	0.502													13	57					0	0	0	0	T	43630388	T	T	43630388	3	4	261	1	0	0	0	0	1	0	0	0	4907	826	29	2	132	2	EBNA1BP2	1	43630388	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5307361	43630388	205620233	18	47394											
PTPRF	5792	broad.mit.edu	37	chr1	44069508	44069508	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcttccggcttgctgccaaGaaccgggctggcttgggtga	6	10	14	11	2	1	2	0	1	1	1	2	2	2	2	3	4	3	4	3	4	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:44069508G>A	uc001cjr.2	+	16	3025	c.2685G>A	c.(2683-2685)AAG>AAA	p.K895K	PTPRF_uc001cjs.2_Silent_p.K886K|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Silent_p.K455K|PTPRF_uc001cjv.2_Silent_p.K355K|PTPRF_uc001cjw.2_Silent_p.K121K	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	895	Extracellular (Potential).|Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TTGCTGCCAAGAACCGGGCTG	0.607													11	26					0	0	0	0	A	44069508	A	A	44069508	2	1	261	1	0	0	0	0	0	0	0	1	12866	933	33	2		2	PTPRF	1	44069508	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	439120	44069508	205181113	19	47395			1	71		3	3	224	G		6.67575e-06
PTPRF	5792	broad.mit.edu	37	chr1	44069632	44069632	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctaccacagaactggcctggGacccgccagtgctggcggag	8	5	14	14	2	0	1	0	0	0	1	0	3	0	3	4	4	3	1	4	4	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:44069632G>T	uc001cjr.2	+	16	3149	c.2809G>T	c.(2809-2811)GAC>TAC	p.D937Y	PTPRF_uc001cjs.2_Missense_Mutation_p.D928Y|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Missense_Mutation_p.D497Y|PTPRF_uc001cjv.2_Missense_Mutation_p.D397Y|PTPRF_uc001cjw.2_Missense_Mutation_p.D163Y	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	937	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACTGGCCTGGGACCCGCCAGT	0.602													9	21					1.12685e-05	1.17958e-05	1	0	T	44069632	T	T	44069632	3	4	261	1	0	0	0	0	1	0	0	0	12866	1174	41	2	2863	2	PTPRF	1	44069632	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	124	44069632	205180989	20	47396			1	71		3	3	224	G		6.67575e-06
PTPRF	5792	broad.mit.edu	37	chr1	44069731	44069731	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctgcagaacatcacgacaGacacccgctttacccttact	12	8	6	15	2	1	2	1	0	0	2	1	3	1	2	2	0	5	3	2	0	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:44069731G>C	uc001cjr.2	+	16	3248	c.2908G>C	c.(2908-2910)GAC>CAC	p.D970H	PTPRF_uc001cjs.2_Missense_Mutation_p.D961H|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Missense_Mutation_p.D530H|PTPRF_uc001cjv.2_Missense_Mutation_p.D430H|PTPRF_uc001cjw.2_Missense_Mutation_p.D196H	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	970	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CATCACGACAGACACCCGCTT	0.597													20	59					0	0	0	0	C	44069731	C	C	44069731	3	2	261	1	0	0	0	0	1	0	0	0	12866	942	33	2	2962	2	PTPRF	1	44069731	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	99	44069731	205180890	21	47397			1	71		3	3	224	G		6.67575e-06
B4GALT2	8704	broad.mit.edu	37	chr1	44456097	44456097	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagtggacattgggcggcctCcgtcgtggccccctcggggc	3	7	16	15	4	0	0	0	0	0	0	3	1	1	1	4	6	0	0	4	6	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:44456097C>T	uc001clg.2	+	7	1466	c.1096C>T	c.(1096-1098)CCG>TCG	p.P366S	B4GALT2_uc001clh.2_Missense_Mutation_p.P300S|B4GALT2_uc010okl.1_Missense_Mutation_p.P395S|B4GALT2_uc001cli.2_Missense_Mutation_p.P366S|CCDC24_uc001clj.2_5'Flank|CCDC24_uc001clk.2_5'Flank|CCDC24_uc009vxc.2_5'Flank	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	366	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	TGGGCGGCCTCCGTCGTGGCC	0.617													26	99					0	0	0	0	T	44456097	T	T	44456097	3	4	261	1	0	0	0	0	1	0	0	0	1273	855	30	2	1118	2	B4GALT2	1	44456097	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	386366	44456097	204794524	22	47398											
B4GALT2	8704	broad.mit.edu	37	chr1	44456112	44456112	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctccgtcgtggccccctCggggctgacactaatggaca	6	7	13	15	3	0	1	0	1	0	0	3	2	1	2	4	5	0	1	4	5	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:44456112C>A	uc001clg.2	+	7	1481	c.1111C>A	c.(1111-1113)CGG>AGG	p.R371R	B4GALT2_uc001clh.2_Silent_p.R305R|B4GALT2_uc010okl.1_Silent_p.R400R|B4GALT2_uc001cli.2_Silent_p.R371R|CCDC24_uc001clj.2_5'Flank|CCDC24_uc001clk.2_5'Flank|CCDC24_uc009vxc.2_5'Flank	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	371	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	GTGGCCCCCTCGGGGCTGACA	0.622													16	81					0.000566183	0.000584572	1	0	A	44456112	A	A	44456112	2	1	261	1	0	0	0	0	0	0	0	1	1273	875	31	3		3	B4GALT2	1	44456112	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	15	44456112	204794509	23	47399											
LRRC42	115353	broad.mit.edu	37	chr1	54426051	54426051	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taactcagctccacctgaagGataattgtttatctgatgct	11	14	7	9	0	2	2	1	2	1	0	3	3	3	3	2	1	3	3	2	1	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:54426051G>A	uc001cwj.1	+	4	828	c.628G>A	c.(628-630)GAT>AAT	p.D210N	LRRC42_uc001cwl.1_Missense_Mutation_p.D210N|LRRC42_uc001cwk.1_Missense_Mutation_p.D210N|LRRC42_uc009vzm.1_Missense_Mutation_p.D210N	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	210	LRR 3.										0						CCACCTGAAGGATAATTGTTT	0.373													32	62					0	0	0	0	A	54426051	A	A	54426051	3	1	261	1	0	0	0	0	1	0	0	0	9050	1174	41	2	638	2	LRRC42	1	54426051	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	9969939	54426051	194824570	24	47400											
HOOK1	51361	broad.mit.edu	37	chr1	60334000	60334000	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaagcagttggcagagaaaGagagaagaattgagattctg	17	7	14	3	0	1	5	0	1	1	5	1	9	1	5	0	1	1	3	0	1	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:60334000G>C	uc009wad.2	+	21	2026	c.1924G>C	c.(1924-1926)GAG>CAG	p.E642Q	HOOK1_uc001czo.2_Missense_Mutation_p.E642Q|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Missense_Mutation_p.E600Q	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	642	Potential.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					GGCAGAGAAAGAGAGAAGAAT	0.303													11	37					0	0	0	0	C	60334000	C	C	60334000	3	2	261	1	0	0	0	0	1	0	0	0	7321	943	33	2	2002	2	HOOK1	1	60334000	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5907949	60334000	188916621	25	47401											
KANK4	163782	broad.mit.edu	37	chr1	62703988	62703988	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctgctccgcgtgggctctCagaagcccagcaatttccat	7	9	9	16	2	1	1	1	0	1	1	4	1	3	1	4	1	3	3	4	1	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:62703988C>T	uc001dah.3	-	10	3326	c.2949G>A	c.(2947-2949)CTG>CTA	p.L983L	KANK4_uc001dai.3_Silent_p.L355L|KANK4_uc001daf.3_Silent_p.L121L|KANK4_uc001dag.3_Silent_p.L339L	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	983	ANK 5.									ovary(3)|skin(2)|lung(1)	6						CGTGGGCTCTCAGAAGCCCAG	0.557													7	29					0	0	0	0	T	62703988	T	T	62703988	2	4	261	1	0	0	0	0	0	0	0	1	8018	813	29	2		2	KANK4	1	62703988	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2369988	62703988	186546633	26	47402											
TCTEX1D1	200132	broad.mit.edu	37	chr1	67236139	67236139	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atctctcgccttacagttcaGatggaaaacacctatcagtt	12	12	6	11	1	3	1	2	0	1	1	5	2	3	2	2	1	2	2	2	1	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:67236139G>A	uc001dcv.2	+	3	320	c.189G>A	c.(187-189)CAG>CAA	p.Q63Q	TCTEX1D1_uc009wau.2_RNA|TCTEX1D1_uc009wav.2_RNA	NM_152665	NP_689878	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	63											0						TTACAGTTCAGATGGAAAACA	0.348													33	105					0	0	0	0	A	67236139	A	A	67236139	2	1	261	1	0	0	0	0	0	0	0	1	15785	933	33	2		2	TCTEX1D1	1	67236139	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4532151	67236139	182014482	27	47403											
C1orf173	127254	broad.mit.edu	37	chr1	75055435	75055435	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacatgtttcccggacttctCagataaaccctctgcaatct	11	12	5	13	1	3	1	1	0	3	1	5	2	4	2	2	1	3	2	2	1	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:75055435C>T	uc001dgg.2	-	12	2275	c.2056G>A	c.(2056-2058)GAG>AAG	p.E686K	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.E480K	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	686	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCGGACTTCTCAGATAAACCC	0.443													16	102					0	0	0	0	T	75055435	T	T	75055435	3	4	261	1	0	0	0	0	1	0	0	0	2023	835	29	2	2548	2	C1orf173	1	75055435	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7819296	75055435	174195186	28	47404											
COL24A1	255631	broad.mit.edu	37	chr1	86289244	86289244	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcctctctctccttttagtCcttgttcaccctggtcacct	4	17	4	16	0	4	0	2	0	2	0	8	0	6	0	5	1	0	1	5	1	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:86289244C>T	uc001dlj.2	-	45	3806	c.3764G>A	c.(3763-3765)GGA>GAA	p.G1255E	COL24A1_uc001dli.2_Missense_Mutation_p.G391E|COL24A1_uc010osd.1_Missense_Mutation_p.G555E|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1255	Collagen-like 14.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCCTTTTAGTCCTTGTTCACC	0.338													21	60					0	0	0	0	T	86289244	T	T	86289244	3	4	261	1	0	0	0	0	1	0	0	0	3698	855	30	2	1444	2	COL24A1	1	86289244	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	11233809	86289244	162961377	29	47405											
CLCA1	1179	broad.mit.edu	37	chr1	86939133	86939133	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcatctctgtatctgcttGaagctacaggaaagcgattt	11	12	10	8	1	2	1	0	1	2	0	3	3	2	2	0	2	4	4	0	2	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:86939133G>C	uc001dlt.2	+	2	325	c.196G>C	c.(196-198)GAA>CAA	p.E66Q	CLCA1_uc001dls.1_Missense_Mutation_p.E66Q	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	66					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GTATCTGCTTGAAGCTACAGG	0.358													7	44					0	0	0	0	C	86939133	C	C	86939133	3	2	261	1	0	0	0	0	1	0	0	0	3472	1291	45	2	202	2	CLCA1	1	86939133	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	649889	86939133	162311488	30	47406											
GBP3	2635	broad.mit.edu	37	chr1	89486310	89486310	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacaggctgtgtaatggcaGacaggattttcagagcttct	10	11	11	9	0	2	2	1	0	1	2	2	3	2	3	1	3	1	4	1	3	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:89486310G>C	uc001dmt.2	-	2	300	c.95C>G	c.(94-96)TCT>TGT	p.S32C	GBP3_uc010oss.1_5'UTR|GBP3_uc001dmu.2_5'UTR|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	32	Helical; (Potential).					integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		TGTAATGGCAGACAGGATTTT	0.517													26	78					0	0	0	0	C	89486310	C	C	89486310	3	2	261	1	0	0	0	0	1	0	0	0	6310	942	33	2	1732	2	GBP3	1	89486310	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2547177	89486310	159764311	31	47407											
BCAR3	8412	broad.mit.edu	37	chr1	94037340	94037340	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagagtggccgctcggtcctCcaaagtgcccgtgcatccca	7	7	11	16	3	0	1	0	0	0	1	4	1	3	1	5	2	2	2	5	2	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:94037340C>T	uc001dpz.2	-	9	2136	c.1861G>A	c.(1861-1863)GAG>AAG	p.E621K	BCAR3_uc001dqa.2_Missense_Mutation_p.E621K|BCAR3_uc001dqb.2_Missense_Mutation_p.E621K|BCAR3_uc001dpx.3_Missense_Mutation_p.E297K|BCAR3_uc001dpy.2_Missense_Mutation_p.E530K|BCAR3_uc009wdm.1_Missense_Mutation_p.E297K	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	621	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		GCTCGGTCCTCCAAAGTGCCC	0.557													6	90					0	0	0	0	T	94037340	T	T	94037340	3	4	261	1	0	0	0	0	1	0	0	0	1351	864	30	2	632	2	BCAR3	1	94037340	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4551030	94037340	155213281	32	47408											
EXTL2	2135	broad.mit.edu	37	chr1	101339776	101339776	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcatcacagttttgagtatCatctatcaaagcatggacag	14	12	7	8	0	5	1	4	1	1	0	5	2	5	2	0	1	1	3	0	1	3	4	rs142198700		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:101339776C>T	uc001dtk.1	-	5	1052	c.715G>A	c.(715-717)GAT>AAT	p.D239N	EXTL2_uc001dtl.1_Missense_Mutation_p.D239N|EXTL2_uc010ouk.1_Missense_Mutation_p.D226N|EXTL2_uc001dtm.1_Missense_Mutation_p.D238N	NM_001439	NP_001430	Q9UBQ6	EXTL2_HUMAN	exostoses-like 2	239	Lumenal (Potential).				N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		TTTTGAGTATCATCTATCAAA	0.383													7	14					0	0	0	0	T	101339776	T	T	101339776	3	4	261	1	0	0	0	0	1	0	0	0	5351	826	29	2	281	2	EXTL2	1	101339776	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7302436	101339776	147910845	33	47409											
CSDE1	7812	broad.mit.edu	37	chr1	115282405	115282405	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacactgaataaatccgtaaGaggttaacagtttttcaata	17	12	6	6	1	1	2	1	1	0	1	2	2	2	2	1	1	2	3	1	1	8	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:115282405G>T	uc001efk.2	-	3	573	c.107C>A	c.(106-108)TCT>TAT	p.S36Y	CSDE1_uc001efi.2_Missense_Mutation_p.S82Y|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.S36Y|CSDE1_uc001efm.2_Missense_Mutation_p.S82Y|CSDE1_uc009wgv.2_Missense_Mutation_p.S36Y|CSDE1_uc001efn.2_Missense_Mutation_p.S36Y	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	36	CSD 1.				male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATCCGTAAGAGGTTAACAG	0.408													97	258					7.47877e-49	8.15375e-49	1	0	T	115282405	T	T	115282405	3	4	261	1	0	0	0	0	1	0	0	0	3946	942	33	2	2361	2	CSDE1	1	115282405	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	13942629	115282405	133968216	34	47410											
NOTCH2	4853	broad.mit.edu	37	chr1	120480487	120480487	+	Frame_Shift_Del	DEL	G	-	-																															gagcaaagcttacctctcctGgaggctgctatgtcacaaga																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:120480487delG	uc001eik.2	-	20	3586	c.3330delC	c.(3328-3330)TCCfs	p.S1110fs	NOTCH2_uc001eil.2_Frame_Shift_Del_p.S1110fs	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1110	EGF-like 29.|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACCTCTCCTGGAGGCTGCTA	0.483			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				---	---	---								-	120480487	-	-	120480487	7	5	261	1	0	1	0	1	0	0	0	0	10602	1335	47	0	4145	0	NOTCH2	1	120480487	Frame_Shift_Del	DEL	G	TCGA-CV-7427-01A-11D-2078-08	5198082	120480487	128770134	35	47411											
CA14	23632	broad.mit.edu	37	chr1	150233959	150233959	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagtgtgacatttgaccctGatttgcctgctctgcagccc	7	12	9	13	0	1	3	0	3	1	0	1	3	1	3	3	0	4	2	3	0	0	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:150233959G>A	uc001etx.2	+	3	487	c.178G>A	c.(178-180)GAT>AAT	p.D60N		NM_012113	NP_036245	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV precursor	60	Extracellular (Potential).					integral to membrane	carbonate dehydratase activity|metal ion binding			ovary(1)	1	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATTTGACCCTGATTTGCCTGC	0.552													14	36					0	0	0	0	A	150233959	A	A	150233959	3	1	261	1	0	0	0	0	1	0	0	0	2527	1290	45	2	188	2	CA14	1	150233959	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	29753472	150233959	99016662	36	47412											
SETDB1	9869	broad.mit.edu	37	chr1	150923439	150923439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcccctatcctgtgtcaatGagattgacacaacccctcca	10	11	5	15	0	1	2	1	2	0	1	4	3	4	2	6	0	1	0	6	0	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:150923439G>A	uc001evu.2	+	13	2276	c.2086G>A	c.(2086-2088)GAG>AAG	p.E696K	SETDB1_uc009wmf.2_Missense_Mutation_p.E697K|SETDB1_uc001evv.2_Missense_Mutation_p.E696K|SETDB1_uc009wmg.1_Missense_Mutation_p.E696K	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	696					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGTGTCAATGAGATTGACAC	0.468													16	52					0	0	0	0	A	150923439	A	A	150923439	3	1	261	1	0	0	0	0	1	0	0	0	14203	1291	45	2	2132	2	SETDB1	1	150923439	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	689480	150923439	98327182	37	47413											
SNX27	81609	broad.mit.edu	37	chr1	151630850	151630850	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagtggccattttcattatCagaacaacaattagatgccc	14	11	7	9	0	2	2	2	0	0	2	2	3	2	2	2	1	3	0	2	1	6	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:151630850C>T	uc001eyn.1	+	3	699	c.683C>T	c.(682-684)TCA>TTA	p.S228L	SNX27_uc001eyo.2_Missense_Mutation_p.S135L|SNX27_uc001eyp.2_Missense_Mutation_p.S42L	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	228	PX.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TTTTCATTATCAGAACAACAA	0.433													18	124					0	0	0	0	T	151630850	T	T	151630850	3	4	261	1	0	0	0	0	1	0	0	0	14961	838	29	2	693	2	SNX27	1	151630850	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	707411	151630850	97619771	38	47414											
HRNR	388697	broad.mit.edu	37	chr1	152191644	152191644	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gccctgtcctgagccagactCgtgttgcccaaaaccagaag	10	7	10	14	1	0	3	0	1	0	2	2	3	1	3	5	0	3	1	5	0	3	1	rs141963410		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:152191644C>G	uc001ezt.1	-	3	2537	c.2461G>C	c.(2461-2463)GAG>CAG	p.E821Q		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	821	8.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCCAGACTCGTGTTGCCCA	0.567													11	45					0	0	0	0	G	152191644	G	G	152191644	3	3	261	1	0	0	0	0	1	0	0	0	7398	893	31	3	6095	3	HRNR	1	152191644	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	560794	152191644	97058977	39	47415											
S100A2	6273	broad.mit.edu	37	chr1	153536239	153536239	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgggcagctccttgtgcaGaagttccttcatttccccct	5	13	9	14	0	1	1	1	0	0	1	4	1	4	1	4	1	2	5	4	1	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:153536239G>C	uc001fcb.2	-	2	450	c.112C>G	c.(112-114)CTG>GTG	p.L38V		NM_005978	NP_005969	P29034	S10A2_HUMAN	S100 calcium binding protein A2	39	EF-hand 1.				endothelial cell migration		calcium ion binding			ovary(1)	1	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCCTTGTGCAGAAGTTCCTTC	0.582													16	43					0	0	0	0	C	153536239	C	C	153536239	3	2	261	1	0	0	0	0	1	0	0	0	13843	933	33	2	189	2	S100A2	1	153536239	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1344595	153536239	95714382	40	47416											
ADAM15	8751	broad.mit.edu	37	chr1	155030888	155030888	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcccagcccctcctgactCtgcctggcacagcctgtggc	4	8	11	18	0	1	1	0	1	1	0	2	1	2	1	6	3	3	1	6	3	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:155030888C>T	uc001fgr.1	+	15	1989	c.1888C>T	c.(1888-1890)CTG>TTG	p.L630L	ADAM15_uc001fgq.1_Silent_p.L315L|ADAM15_uc010pet.1_Silent_p.L614L|ADAM15_uc010peu.1_Silent_p.L647L|ADAM15_uc001fgt.1_Silent_p.L630L|ADAM15_uc010pev.1_Silent_p.L640L|ADAM15_uc001fgs.1_Silent_p.L630L|ADAM15_uc001fgu.1_Silent_p.L630L|ADAM15_uc001fgw.1_Silent_p.L630L|ADAM15_uc001fgv.1_Silent_p.L630L|ADAM15_uc001fgx.1_Silent_p.L630L|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_5'UTR	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	630	Extracellular (Potential).|Cys-rich.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CCTCCTGACTCTGCCTGGCAC	0.597													8	24					0	0	0	0	T	155030888	T	T	155030888	2	4	261	1	0	0	0	0	0	0	0	1	237	912	32	2		2	ADAM15	1	155030888	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1494649	155030888	94219733	41	47417											
CD1E	913	broad.mit.edu	37	chr1	158324275	158324275	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggcacacagtgagggctCaggatggctgggtgacctgc	7	7	17	10	0	1	2	1	2	0	0	1	3	1	3	1	5	1	3	1	5	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:158324275C>T	uc001fse.2	+	2	406	c.167C>T	c.(166-168)TCA>TTA	p.S56L	CD1E_uc010pid.1_Missense_Mutation_p.S54L|CD1E_uc010pie.1_Intron|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.S56L|CD1E_uc001fsk.2_Missense_Mutation_p.S56L|CD1E_uc001fsj.2_Missense_Mutation_p.S56L|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.S56L|CD1E_uc001fry.2_Missense_Mutation_p.S56L|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.S56L|CD1E_uc009wsv.2_Intron|CD1E_uc001frz.2_Missense_Mutation_p.S56L|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	56					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					AGTGAGGGCTCAGGATGGCTG	0.567													19	52					0	0	0	0	T	158324275	T	T	158324275	3	4	261	1	0	0	0	0	1	0	0	0	2993	838	29	2	173	2	CD1E	1	158324275	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3293387	158324275	90926346	42	47418											
SPTA1	6708	broad.mit.edu	37	chr1	158641186	158641186	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaaagtcttcatgcttctGaagaagggcttctgcactgc	9	12	9	11	0	5	2	2	1	3	1	5	2	5	2	0	1	3	3	0	1	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:158641186G>A	uc001fst.1	-	12	1745	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	516	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCATGCTTCTGAAGAAGGGCT	0.488													9	36					0	0	0	0	A	158641186	A	A	158641186	4	1	261	1	0	0	0	0	0	1	0	0	15182	1299	45	2	5877	2	SPTA1	1	158641186	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	316911	158641186	90609435	43	47419											
COPA	1314	broad.mit.edu	37	chr1	160281696	160281696	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctacatctttggagctgttGaaatccagctgtcgtaagaa	11	12	10	8	1	1	2	0	1	1	1	3	3	2	3	1	1	3	5	1	1	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:160281696G>A	uc009wti.2	-	11	1432	c.1038C>T	c.(1036-1038)TTC>TTT	p.F346F	COPA_uc001fvv.3_Silent_p.F346F|COPA_uc009wtj.1_Silent_p.F292F	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	346					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGGAGCTGTTGAAATCCAGCT	0.473													6	28					0	0	0	0	A	160281696	A	A	160281696	2	1	261	1	0	0	0	0	0	0	0	1	3742	1281	45	2		2	COPA	1	160281696	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1640510	160281696	88968925	44	47420											
CD84	8832	broad.mit.edu	37	chr1	160535406	160535406	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggtgttacataagcaacaGatgttttagaagtccaagca	14	11	9	7	0	0	2	0	0	0	2	1	2	1	2	1	1	4	4	1	1	6	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:160535406G>A	uc001fwh.3	-	2	200	c.176C>T	c.(175-177)TCT>TTT	p.S59F	CD84_uc001fwf.3_Missense_Mutation_p.S59F|CD84_uc001fwg.3_Missense_Mutation_p.S59F|CD84_uc009wtn.2_Missense_Mutation_p.S59F|CD84_uc001fwi.3_Intron|CD84_uc001fwj.2_Missense_Mutation_p.S59F|CD84_uc001fwk.2_Missense_Mutation_p.S59F	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	59	Extracellular (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATAAGCAACAGATGTTTTAGA	0.423													36	111					0	0	0	0	A	160535406	A	A	160535406	3	1	261	1	0	0	0	0	1	0	0	0	3057	942	33	2	889	2	CD84	1	160535406	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	253710	160535406	88715215	45	47421											
C1orf156	92342	broad.mit.edu	37	chr1	169761757	169761757	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttatttcaattatgaacctCttcaatccttcatcaattat	12	18	2	9	0	5	1	4	1	1	0	6	1	6	1	2	0	1	1	2	0	7	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:169761757C>T	uc001ggn.2	-	2	1358	c.1080G>A	c.(1078-1080)AAG>AAA	p.K360K	C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggo.2_5'Flank|uc010plt.1_5'Flank|C1orf112_uc001ggp.2_5'Flank|C1orf112_uc001ggq.2_5'Flank	NM_033418	NP_219486	O95568	MET18_HUMAN	hypothetical protein MGC9084	360						cytoplasm	protein methyltransferase activity				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTATGAACCTCTTCAATCCTT	0.308													3	8					0	0	0	0	T	169761757	T	T	169761757	2	4	261	1	0	0	0	0	0	0	0	1	2015	912	32	2		2	C1orf156	1	169761757	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	9226351	169761757	79488864	46	47422											
TNR	7143	broad.mit.edu	37	chr1	175299264	175299264	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacaggtttctgctgtcctCgacagagaacctgtcgtagg	8	11	12	10	2	1	1	0	0	1	1	4	3	2	1	2	2	3	4	2	2	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:175299264C>A	uc001gkp.1	-	19	3820	c.3739G>T	c.(3739-3741)GAG>TAG	p.E1247*	TNR_uc009wwu.1_Nonsense_Mutation_p.E1247*	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1247	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CTGCTGTCCTCGACAGAGAAC	0.587													13	32					4.3838e-07	4.62097e-07	1	0	A	175299264	A	A	175299264	4	1	261	1	0	0	0	0	0	1	0	0	16404	893	31	3	349	3	TNR	1	175299264	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5537507	175299264	73951357	47	47423											
FAM20B	9917	broad.mit.edu	37	chr1	179041145	179041145	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatgaccccatctccccaGtgctctctgatcctcatctg	6	11	5	19	0	4	2	1	2	3	0	7	2	5	2	6	0	1	1	6	0	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:179041145G>A	uc001gmc.2	+	8	1389	c.1096G>A	c.(1096-1098)GTG>ATG	p.V366M		NM_014864	NP_055679	O75063	XYLK_HUMAN	hypothetical protein LOC9917 precursor	366	Lumenal (Potential).					Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(3)	3						CATCTCCCCAGTGCTCTCTGA	0.557													35	89					0	0	0	0	A	179041145	A	A	179041145	3	1	261	1	0	0	0	0	1	0	0	0	5566	1029	36	4	1122	4	FAM20B	1	179041145	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3741881	179041145	70209476	48	47424											
TMCC2	9911	broad.mit.edu	37	chr1	205238423	205238423	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccggcgcctgaaggagattGagcagaacgggccctcgcgg	8	4	17	12	5	0	4	0	2	0	2	1	5	0	4	3	4	2	1	3	4	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:205238423G>C	uc001hbz.1	+	4	1537	c.1093G>C	c.(1093-1095)GAG>CAG	p.E365Q	TMCC2_uc010prf.1_Missense_Mutation_p.E287Q|TMCC2_uc001hca.2_Missense_Mutation_p.E140Q|TMCC2_uc001hcb.1_Missense_Mutation_p.E125Q|TMCC2_uc001hcc.1_5'UTR|TMCC2_uc001hcd.2_Missense_Mutation_p.E132Q	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	365	Potential.					integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GAAGGAGATTGAGCAGAACGG	0.632													9	9					0	0	0	0	C	205238423	C	C	205238423	3	2	261	1	0	0	0	0	1	0	0	0	16059	1291	45	2	1103	2	TMCC2	1	205238423	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	26197278	205238423	44012198	49	47425											
CR2	1380	broad.mit.edu	37	chr1	207643212	207643212	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgttgtacagttgatagtcaGaagactgggacctggagtgg	10	10	15	6	1	1	3	1	1	0	2	1	5	1	5	1	3	1	3	1	3	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:207643212G>A	uc001hfw.2	+	6	1084	c.990G>A	c.(988-990)CAG>CAA	p.Q330Q	CR2_uc001hfv.2_Silent_p.Q330Q|CR2_uc009xch.2_Silent_p.Q330Q|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	330	Sushi 5.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TTGATAGTCAGAAGACTGGGA	0.517													10	25					0	0	0	0	A	207643212	A	A	207643212	2	1	261	1	0	0	0	0	0	0	0	1	3857	933	33	2		2	CR2	1	207643212	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2404789	207643212	41607409	50	47426											
SERTAD4	56256	broad.mit.edu	37	chr1	210415084	210415084	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccctgcctgctctttcaatgGcacctctgcccaagagtggt	6	11	9	15	0	3	1	1	0	2	1	3	1	3	1	4	2	3	2	4	2	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:210415084G>A	uc001hhy.2	+	4	652	c.473G>A	c.(472-474)GGC>GAC	p.G158D	SERTAD4_uc009xcw.2_Missense_Mutation_p.G158D	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	158							protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TCTTTCAATGGCACCTCTGCC	0.453													42	97					0	0	0	0	A	210415084	A	A	210415084	3	1	261	1	0	0	0	0	1	0	0	0	14188	1203	42	4	483	4	SERTAD4	1	210415084	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2771872	210415084	38835537	51	47427											
KCNK2	3776	broad.mit.edu	37	chr1	215368397	215368397	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcctgagcatgattggaGattggctccgagtgatatct	8	13	12	8	1	1	4	0	3	1	1	3	6	3	4	2	2	1	2	2	2	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:215368397G>A	uc001hkq.2	+	6	1094	c.925G>A	c.(925-927)GAT>AAT	p.D309N	KCNK2_uc001hko.2_Missense_Mutation_p.D305N|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.D294N	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	309	Cytoplasmic (Potential).			DWL -> RLV (in Ref. 3; AAD01203).			outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CATGATTGGAGATTGGCTCCG	0.373													46	134					0	0	0	0	A	215368397	A	A	215368397	3	1	261	1	0	0	0	0	1	0	0	0	8105	942	33	2	990	2	KCNK2	1	215368397	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4953313	215368397	33882224	52	47428											
ZNF678	339500	broad.mit.edu	37	chr1	227842557	227842557	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaactagccataagaaaatTcatagtggagagaaaccata	19	8	7	7	0	1	2	1	0	0	2	1	4	1	3	2	1	3	0	2	1	8	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:227842557T>G	uc001hqw.1	+	4	951	c.606T>G	c.(604-606)ATT>ATG	p.I202M	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	257					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				ATAAGAAAATTCATAGTGGAG	0.368													39	116					0	0	0	0	G	227842557	G	G	227842557	3	3	261	1	0	0	0	0	1	0	0	0	18152	1771	62	5	785	5	ZNF678	1	227842557	Missense_Mutation	SNP	T	TCGA-CV-7427-01A-11D-2078-08	12474160	227842557	21408064	53	47429											
KIDINS220	57498	broad.mit.edu	37	chr2	8871880	8871880	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttttcttgctctaggtttGaatgaatagagccccctgat	8	15	8	10	0	2	4	0	3	2	1	2	4	2	4	3	1	2	2	3	1	4	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:8871880G>C	uc002qzc.2	-	30	4468	c.4286C>G	c.(4285-4287)TCA>TGA	p.S1429*	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Nonsense_Mutation_p.S1330*|KIDINS220_uc002qzb.2_Nonsense_Mutation_p.S283*	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1429	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTCTAGGTTTGAATGAATAGA	0.463													29	99					0	0	0	0	C	8871880	C	C	8871880	4	2	261	1	0	0	0	0	0	1	0	0	8310	1294	45	2	1033	2	KIDINS220	2	8871880	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08		8871880	234327493	54	47430											
NBAS	51594	broad.mit.edu	37	chr2	15415720	15415720	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cataggcatgaagccactccGgtgaagagcctgggacttgt	10	8	13	10	1	0	3	0	2	0	1	1	4	1	4	3	3	2	1	3	3	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:15415720G>A	uc002rcc.1	-	44	5638	c.5612C>T	c.(5611-5613)CCG>CTG	p.P1871L	NBAS_uc010exl.1_Missense_Mutation_p.P943L|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1871										ovary(2)|liver(1)|skin(1)	4						AAGCCACTCCGGTGAAGAGCC	0.478													14	50					0	0	0	0	A	15415720	A	A	15415720	3	1	261	1	0	0	0	0	1	0	0	0	10239	1116	39	1	1539	1	NBAS	2	15415720	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	6543840	15415720	227783653	55	47431											
KCNS3	3790	broad.mit.edu	37	chr2	18113476	18113476	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcatcttggtggtggcccttCccatcaccatcatcttcaac	7	12	7	15	0	5	0	3	0	2	0	6	0	6	0	3	3	1	1	3	3	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:18113476C>G	uc002rcv.2	+	3	1652	c.1201C>G	c.(1201-1203)CCC>GCC	p.P401A	KCNS3_uc002rcw.2_Missense_Mutation_p.P401A	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	401	Helical; Name=Segment S6; (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGTGGCCCTTCCCATCACCAT	0.517													20	48					0	0	0	0	G	18113476	G	G	18113476	3	3	261	1	0	0	0	0	1	0	0	0	8129	855	30	2	1203	2	KCNS3	2	18113476	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2697756	18113476	225085897	56	47432											
ASXL2	55252	broad.mit.edu	37	chr2	25965130	25965130	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagtgacagtcactgaaaatGacatgacatcacctacattg	15	10	7	9	0	2	4	2	4	0	0	2	4	2	4	1	0	1	0	1	0	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:25965130G>A	uc002rgs.2	-	12	4297	c.4076C>T	c.(4075-4077)TCA>TTA	p.S1359L	ASXL2_uc002rgt.1_Missense_Mutation_p.S842L	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	1359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACTGAAAATGACATGACATC	0.493													9	21					0	0	0	0	A	25965130	A	A	25965130	3	1	261	1	0	0	0	0	1	0	0	0	1069	1294	45	2	235	2	ASXL2	2	25965130	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	7851654	25965130	217234243	57	47433											
BIRC6	57448	broad.mit.edu	37	chr2	32605289	32605289	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagagggttatgatttgttCatcacacagctcaaagatgg	13	11	10	7	0	3	3	3	1	0	2	3	3	3	3	0	2	1	3	0	2	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:32605289C>T	uc010ezu.2	+	3	710	c.576C>T	c.(574-576)TTC>TTT	p.F192F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	192					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATGATTTGTTCATCACACAGC	0.333													3	10					0	0	0	0	T	32605289	T	T	32605289	2	4	261	1	0	0	0	0	0	0	0	1	1441	825	29	2		2	BIRC6	2	32605289	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	6640159	32605289	210594084	58	47434											
VIT	5212	broad.mit.edu	37	chr2	37028511	37028511	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagatctgaagacagccataGagaaaattactcagagagga	18	6	11	6	0	2	5	1	1	1	4	2	9	2	6	1	1	2	0	1	1	5	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:37028511G>C	uc002rpl.2	+	13	1347	c.1126G>C	c.(1126-1128)GAG>CAG	p.E376Q	VIT_uc002rpm.2_Missense_Mutation_p.E354Q|VIT_uc010ezv.2_Missense_Mutation_p.E332Q|VIT_uc010ezw.2_Missense_Mutation_p.E333Q	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	361	VWFA 1.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				GACAGCCATAGAGAAAATTAC	0.393													39	106					0	0	0	0	C	37028511	C	C	37028511	3	2	261	1	0	0	0	0	1	0	0	0	17239	943	33	2	1297	2	VIT	2	37028511	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4423222	37028511	206170862	59	47435											
CCDC88A	55704	broad.mit.edu	37	chr2	55561259	55561259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtaaccaacgtttttatatCaatagttgctcttttcacaa	12	17	4	8	1	3	0	2	0	1	0	3	0	3	0	1	0	3	4	1	0	7	9			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:55561259C>T	uc002ryv.2	-	15	3540	c.2698G>A	c.(2698-2700)GAT>AAT	p.D900N	CCDC88A_uc010yoz.1_Missense_Mutation_p.D900N|CCDC88A_uc010ypa.1_Missense_Mutation_p.D900N|CCDC88A_uc010ypb.1_Missense_Mutation_p.D802N|CCDC88A_uc002ryu.2_Missense_Mutation_p.D183N|CCDC88A_uc002ryw.2_Missense_Mutation_p.D183N	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	900	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						GTTTTTATATCAATAGTTGCT	0.279													10	27					0	0	0	0	T	55561259	T	T	55561259	3	4	261	1	0	0	0	0	1	0	0	0	2876	826	29	2	2989	2	CCDC88A	2	55561259	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	18532748	55561259	187638114	60	47436											
KIAA1841	84542	broad.mit.edu	37	chr2	61300626	61300626	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcttccacaaggaattgttCttcagaaagtgaaaattgta	15	12	8	6	0	2	2	1	1	1	1	3	3	3	3	1	1	1	3	1	1	6	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:61300626C>G	uc002saw.3	+	5	674	c.371C>G	c.(370-372)TCT>TGT	p.S124C	KIAA1841_uc002sax.3_Intron|KIAA1841_uc002say.2_Missense_Mutation_p.S124C|KIAA1841_uc002sav.3_Missense_Mutation_p.S124C	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	124											0			Epithelial(17;0.193)			AGGAATTGTTCTTCAGAAAGT	0.353													10	35					0	0	0	0	G	61300626	G	G	61300626	3	3	261	1	0	0	0	0	1	0	0	0	8300	913	32	2	381	2	KIAA1841	2	61300626	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5739367	61300626	181898747	61	47437											
ARHGAP25	9938	broad.mit.edu	37	chr2	69045102	69045102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atctcatcaggtcgaaggtcGaagaccctgccgtgatcatg	10	9	11	11	3	3	2	3	1	1	1	6	4	3	2	2	2	1	0	2	2	2	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:69045102G>A	uc002seu.2	+	8	1340	c.976G>A	c.(976-978)GAA>AAA	p.E326K	ARHGAP25_uc010fdg.2_Missense_Mutation_p.E327K|ARHGAP25_uc010yql.1_Missense_Mutation_p.E287K|ARHGAP25_uc002sev.2_Missense_Mutation_p.E320K|ARHGAP25_uc002sew.2_Missense_Mutation_p.E319K|ARHGAP25_uc002sex.2_Missense_Mutation_p.E320K|ARHGAP25_uc010fdh.1_RNA|ARHGAP25_uc002sey.2_Missense_Mutation_p.E53K	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	326	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						GTCGAAGGTCGAAGACCCTGC	0.418													15	36					0	0	0	0	A	69045102	A	A	69045102	3	1	261	1	0	0	0	0	1	0	0	0	874	1059	37	1	1049	1	ARHGAP25	2	69045102	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	7744476	69045102	174154271	62	47438											
HTRA2	27429	broad.mit.edu	37	chr2	74757145	74757145	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcggagctgatggctgcgccGagggcggggcggggtgcagg	4	4	24	9	5	0	1	0	1	0	0	0	3	0	2	1	8	3	3	1	8	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:74757145G>A	uc002smi.1	+	1	614	c.12G>A	c.(10-12)CCG>CCA	p.P4P	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Silent_p.P4P|HTRA2_uc002smk.1_Silent_p.P4P|HTRA2_uc002sml.1_Silent_p.P4P|HTRA2_uc002smm.1_Intron|HTRA2_uc002smn.1_Intron|HTRA2_uc010ffl.2_5'Flank	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	4					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						TGGCTGCGCCGAGGGCGGGGC	0.741													8	33					0	0	0	0	A	74757145	A	A	74757145	2	1	261	1	0	0	0	0	0	0	0	1	7493	1045	37	1		1	HTRA2	2	74757145	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5712043	74757145	168442228	63	47439											
HTRA2	27429	broad.mit.edu	37	chr2	74757169	74757169	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcggggcggggtgcaggctgGagccttcgggcatggcgggc	3	5	23	10	4	0	0	0	0	0	0	1	1	0	1	1	9	2	3	1	9	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:74757169G>C	uc002smi.1	+	1	638	c.36G>C	c.(34-36)TGG>TGC	p.W12C	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Missense_Mutation_p.W12C|HTRA2_uc002smk.1_Missense_Mutation_p.W12C|HTRA2_uc002sml.1_Missense_Mutation_p.W12C|HTRA2_uc002smm.1_Intron|HTRA2_uc002smn.1_Intron|HTRA2_uc010ffl.2_5'Flank	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	12					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						GTGCAGGCTGGAGCCTTCGGG	0.716													10	39					0	0	0	0	C	74757169	C	C	74757169	3	2	261	1	0	0	0	0	1	0	0	0	7493	1183	41	2	38	2	HTRA2	2	74757169	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	24	74757169	168442204	64	47440											
HK2	3099	broad.mit.edu	37	chr2	75100416	75100416	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttccagagtttcctggtctCatggaccaagggattcaagt	9	13	10	9	0	2	1	2	0	1	1	5	3	4	3	3	3	0	1	3	3	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:75100416C>G	uc002snd.2	+	5	2435	c.509C>G	c.(508-510)TCA>TGA	p.S170*		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	170	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						TTCCTGGTCTCATGGACCAAG	0.522													17	94					0	0	0	0	G	75100416	G	G	75100416	4	3	261	1	0	0	0	0	0	1	0	0	7230	838	29	2	527	2	HK2	2	75100416	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	343247	75100416	168098957	65	47441											
TMEM131	23505	broad.mit.edu	37	chr2	98409038	98409038	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggggcgggagacagcctttCaggctgcggctcctggggct	4	7	19	11	2	1	1	1	0	0	1	2	2	2	1	2	7	2	3	2	7	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:98409038C>G	uc002syh.3	-	31	4184	c.3955G>C	c.(3955-3957)GAA>CAA	p.E1319Q		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1319	Pro-rich.					integral to membrane				ovary(4)|central_nervous_system(2)	6						GACAGCCTTTCAGGCTGCGGC	0.677													6	9					0	0	0	0	G	98409038	G	G	98409038	3	3	261	1	0	0	0	0	1	0	0	0	16110	835	29	2	1740	2	TMEM131	2	98409038	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	23308622	98409038	144790335	66	47442											
CHST10	9486	broad.mit.edu	37	chr2	101010229	101010229	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcttacaataaaaaacttGaagtatgttttcaatctaag	16	15	4	6	0	3	1	1	1	2	0	4	1	3	1	0	0	2	2	0	0	9	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:101010229G>C	uc002tam.2	-	7	908	c.549C>G	c.(547-549)TTC>TTG	p.F183L		NM_004854	NP_004845	O43529	CHSTA_HUMAN	HNK-1 sulfotransferase	183	Lumenal (Potential).				carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				ovary(1)	1						TAAAAAACTTGAAGTATGTTT	0.423													13	37					0	0	0	0	C	101010229	C	C	101010229	3	2	261	1	0	0	0	0	1	0	0	0	3413	1281	45	2	525	2	CHST10	2	101010229	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2601191	101010229	142189144	67	47443											
SMPD4	55627	broad.mit.edu	37	chr2	130911298	130911298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaatatctggcgcaggtactCcagggccttctccaggtatt	8	11	11	11	1	2	0	0	0	2	0	4	1	3	0	3	4	1	3	3	4	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:130911298C>T	uc002tqq.1	-	17	2507	c.1987G>A	c.(1987-1989)GAG>AAG	p.E663K	SMPD4_uc002tqo.1_Missense_Mutation_p.E195K|SMPD4_uc002tqp.1_Missense_Mutation_p.E402K|SMPD4_uc010yzy.1_Missense_Mutation_p.E412K|SMPD4_uc010yzz.1_Missense_Mutation_p.E327K|SMPD4_uc002tqr.1_Missense_Mutation_p.E634K|SMPD4_uc002tqs.1_Missense_Mutation_p.E531K|SMPD4_uc002tqt.1_Missense_Mutation_p.E512K|SMPD4_uc010zaa.1_Missense_Mutation_p.E521K|SMPD4_uc010zab.1_Missense_Mutation_p.E561K|SMPD4_uc010zac.1_Missense_Mutation_p.E404K|SMPD4_uc010zad.1_Missense_Mutation_p.E299K	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	624					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	CGCAGGTACTCCAGGGCCTTC	0.597													6	45					0	0	0	0	T	130911298	T	T	130911298	3	4	261	1	0	0	0	0	1	0	0	0	14871	864	30	2	629	2	SMPD4	2	130911298	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	29901069	130911298	112288075	68	47444											
LRP1B	53353	broad.mit.edu	37	chr2	141259290	141259290	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaggtcttgacagtcttgaGaacatccactgactttctta	11	13	8	9	0	3	3	0	3	3	1	4	5	4	3	1	1	1	0	1	1	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:141259290G>A	uc002tvj.1	-	55	9788	c.8816C>T	c.(8815-8817)TCT>TTT	p.S2939F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2939	Extracellular (Potential).|EGF-like 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACAGTCTTGAGAACATCCACT	0.388										TSP Lung(27;0.18)			12	79					0	0	0	0	A	141259290	A	A	141259290	3	1	261	1	0	0	0	0	1	0	0	0	9005	942	33	2	5131	2	LRP1B	2	141259290	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	10347992	141259290	101940083	69	47445											
CSRNP3	80034	broad.mit.edu	37	chr2	166533010	166533010	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagattgacgtggaagaaaaGcacgaactccgagccatccg	15	5	11	10	4	0	3	0	1	0	2	2	6	2	4	3	1	3	1	3	1	5	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:166533010G>T	uc002udf.2	+	6	973	c.597G>T	c.(595-597)AAG>AAT	p.K199N	CSRNP3_uc002udg.2_Missense_Mutation_p.K199N	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	199					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						TGGAAGAAAAGCACGAACTCC	0.522													30	78					1.2476e-16	1.34803e-16	1	0	T	166533010	T	T	166533010	3	4	261	1	0	0	0	0	1	0	0	0	3982	962	34	4	607	4	CSRNP3	2	166533010	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	25273720	166533010	76666363	70	47446											
HOXD10	3236	broad.mit.edu	37	chr2	176982029	176982029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatattttagactgagtcaGacctacgccaccgggaaaac	13	8	10	10	2	1	3	1	1	0	2	1	5	1	5	3	2	2	0	3	2	5	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:176982029G>C	uc002ukj.2	+	1	538	c.468G>C	c.(466-468)CAG>CAC	p.Q156H		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	156						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GACTGAGTCAGACCTACGCCA	0.582													16	107					0	0	0	0	C	176982029	C	C	176982029	3	2	261	1	0	0	0	0	1	0	0	0	7358	933	33	2	470	2	HOXD10	2	176982029	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	10449019	176982029	66217344	71	47447											
STAT1	6772	broad.mit.edu	37	chr2	191859795	191859795	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccttgagttacctctgaatGagctgctggaaaagactgaa	12	10	10	9	0	1	5	0	4	1	1	1	6	1	6	2	1	3	3	2	1	5	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:191859795G>C	uc002usj.2	-	10	1324	c.936C>G	c.(934-936)CTC>CTG	p.L312L	STAT1_uc010fse.1_Silent_p.L312L|STAT1_uc002usk.2_Silent_p.L312L|STAT1_uc002usl.2_Silent_p.L314L|STAT1_uc010fsf.1_Silent_p.L124L	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	312					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	ACCTCTGAATGAGCTGCTGGA	0.388													7	44					0	0	0	0	C	191859795	C	C	191859795	2	2	261	1	0	0	0	0	0	0	0	1	15330	1277	45	2		2	STAT1	2	191859795	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	14877766	191859795	51339578	72	47448											
STAT1	6772	broad.mit.edu	37	chr2	191859849	191859849	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacacttgtttgttttttgtGatagggtcatgttcgtaggt	7	19	11	4	1	1	1	1	1	0	0	2	1	1	1	0	2	1	4	0	2	3	8			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:191859849G>C	uc002usj.2	-	10	1270	c.882C>G	c.(880-882)ATC>ATG	p.I294M	STAT1_uc010fse.1_Missense_Mutation_p.I294M|STAT1_uc002usk.2_Missense_Mutation_p.I294M|STAT1_uc002usl.2_Missense_Mutation_p.I296M|STAT1_uc010fsf.1_Missense_Mutation_p.I106M	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	294					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TGTTTTTTGTGATAGGGTCAT	0.438													7	49					0	0	0	0	C	191859849	C	C	191859849	3	2	261	1	0	0	0	0	1	0	0	0	15330	1280	45	2	1438	2	STAT1	2	191859849	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	54	191859849	51339524	73	47449											
NBEAL1	65065	broad.mit.edu	37	chr2	204000956	204000956	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggctttagtgatgacttctCtttacttgaaagccaagagg	10	13	11	7	0	1	4	0	3	1	1	2	4	1	4	1	2	2	1	1	2	4	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:204000956C>G	uc002uzt.3	+	27	4616	c.4283C>G	c.(4282-4284)TCT>TGT	p.S1428C	NBEAL1_uc002uzs.3_Missense_Mutation_p.S138C	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1428							binding			ovary(1)|skin(1)	2						GATGACTTCTCTTTACTTGAA	0.363													11	40					0	0	0	0	G	204000956	G	G	204000956	3	3	261	1	0	0	0	0	1	0	0	0	10241	913	32	2	4385	2	NBEAL1	2	204000956	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	12141107	204000956	39198417	74	47450											
GLB1L	79411	broad.mit.edu	37	chr2	220102389	220102389	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacaaggttatcaattttcaGagggaacatcatccactggg	13	10	9	9	0	3	1	3	0	0	1	4	2	4	2	1	3	1	1	1	3	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:220102389G>C	uc002vkm.2	-	16	1773	c.1534C>G	c.(1534-1536)CTG>GTG	p.L512V	GLB1L_uc002vkk.2_Missense_Mutation_p.L269V|GLB1L_uc010zkx.1_Missense_Mutation_p.L422V|GLB1L_uc002vkn.2_Missense_Mutation_p.L512V	NM_024506	NP_078782	Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like precursor	512					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds				0		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAATTTTCAGAGGGAACATC	0.453													19	46					0	0	0	0	C	220102389	C	C	220102389	3	2	261	1	0	0	0	0	1	0	0	0	6465	933	33	2	438	2	GLB1L	2	220102389	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	16101433	220102389	23096984	75	47451											
STK16	8576	broad.mit.edu	37	chr2	220111834	220111834	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagggaaacttgtgttgcaGagaggtacgctgtggaatga	11	10	16	4	1	0	2	0	1	0	1	0	5	0	4	0	3	3	5	0	3	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:220111834G>C	uc002vko.2	+	4	464	c.307_splice	c.e4-1	p.R103_splice	GLB1L_uc002vkm.2_5'Flank|GLB1L_uc002vkn.2_5'Flank|STK16_uc002vks.2_Intron|STK16_uc010zky.1_Splice_Site_p.R103_splice|STK16_uc010fwf.2_Splice_Site_p.R103_splice|STK16_uc002vkp.2_Splice_Site_p.R103_splice|STK16_uc002vkr.2_Splice_Site_p.R36_splice|STK16_uc002vkq.2_Splice_Site_p.R148_splice	NM_001008910	NP_001008910	O75716	STK16_HUMAN	serine/threonine kinase 16						protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGTGTTGCAGAGAGGTACGC	0.502													9	21					0	0	0	0	C	220111834	C	C	220111834	5	2	261	1	0	0	0	0	0	0	1	0	15355	956	33	2	316	2	STK16	2	220111834	Splice_Site	SNP	G	TCGA-CV-7427-01A-11D-2078-08	9445	220111834	23087539	76	47452											
IRS1	3667	broad.mit.edu	37	chr2	227660640	227660640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccatcttcatgtactcctCagtgccagtctcttcctctc	5	15	5	16	0	5	0	2	0	3	0	10	0	8	0	4	0	2	1	4	0	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:227660640C>T	uc002voh.3	-	1	2867	c.2815G>A	c.(2815-2817)GAG>AAG	p.E939K		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	939					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		ATGTACTCCTCAGTGCCAGTC	0.652													19	82					0	0	0	0	T	227660640	T	T	227660640	3	4	261	1	0	0	0	0	1	0	0	0	7879	835	29	2	917	2	IRS1	2	227660640	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7548806	227660640	15538733	77	47453											
GIGYF2	26058	broad.mit.edu	37	chr2	233710554	233710554	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggatttacgcagtggtgtGaacagatgcttcatgccctt	9	13	11	8	1	1	2	1	1	0	1	1	3	1	3	1	2	4	2	1	2	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:233710554G>A	uc002vti.3	+	28	3755	c.3418G>A	c.(3418-3420)GAA>AAA	p.E1140K	GIGYF2_uc002vtj.3_Missense_Mutation_p.E1161K|GIGYF2_uc002vtk.3_Missense_Mutation_p.E1140K|GIGYF2_uc002vth.3_Missense_Mutation_p.E1134K|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc002vtq.3_Missense_Mutation_p.E473K	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	1140					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GCAGTGGTGTGAACAGATGCT	0.274													11	40					0	0	0	0	A	233710554	A	A	233710554	3	1	261	1	0	0	0	0	1	0	0	0	6415	1291	45	2	3582	2	GIGYF2	2	233710554	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	6049914	233710554	9488819	78	47454											
INPP5D	3635	broad.mit.edu	37	chr2	234104054	234104054	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttccttccagactttgtgaAgacggagcgtgatgaatcca	10	12	10	9	2	0	5	0	3	0	2	3	6	3	6	3	1	1	0	3	1	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:234104054A>G	uc010zmo.1	+	23	2759	c.2606A>G	c.(2605-2607)AAG>AGG	p.K869R	INPP5D_uc010zmp.1_Missense_Mutation_p.K868R	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	869					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GACTTTGTGAAGACGGAGCGT	0.473													15	50					0	0	0	0	G	234104054	G	G	234104054	3	3	261	1	0	0	0	0	1	0	0	0	7795	72	3	5	2208	5	INPP5D	2	234104054	Missense_Mutation	SNP	A	TCGA-CV-7427-01A-11D-2078-08	393500	234104054	9095319	79	47455											
TRPM8	79054	broad.mit.edu	37	chr2	234888876	234888876	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttactgacctgtggaatgtGatggacacgctggggctttt	7	14	13	7	1	0	2	0	2	0	0	0	4	0	4	1	4	1	2	1	4	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:234888876G>T	uc002vvh.2	+	18	2440	c.2400G>T	c.(2398-2400)GTG>GTT	p.V800V	TRPM8_uc010fyj.2_Silent_p.V378V|TRPM8_uc010fyk.2_5'Flank	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	800	Helical; Name=4; (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TGTGGAATGTGATGGACACGC	0.408													6	25					0.00198382	0.00203089	1	0	T	234888876	T	T	234888876	2	4	261	1	0	0	0	0	0	0	0	1	16659	1277	45	2		2	TRPM8	2	234888876	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	784822	234888876	8310497	80	47456											
HDLBP	3069	broad.mit.edu	37	chr2	242194963	242194963	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacttgtgttgggatttcttCacttccactgcaatggttgt	6	18	9	8	0	2	0	1	0	1	0	3	1	3	1	1	2	2	3	1	2	2	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:242194963C>G	uc002waz.2	-	8	1134	c.906G>C	c.(904-906)GTG>GTC	p.V302V	HDLBP_uc002wba.2_Silent_p.V302V|HDLBP_uc002wbb.2_Intron|HDLBP_uc010fzn.1_Intron	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	302	KH 2.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		GGGATTTCTTCACTTCCACTG	0.493													20	74					0	0	0	0	G	242194963	G	G	242194963	2	3	261	1	0	0	0	0	0	0	0	1	7064	813	29	2		2	HDLBP	2	242194963	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7306087	242194963	1004410	81	47457											
LRRN1	57633	broad.mit.edu	37	chr3	3887186	3887186	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggacttcaaaaatatgctTcggttaaaagaactgggaat	15	10	11	5	1	1	1	1	0	0	1	2	3	1	3	0	4	2	2	0	4	7	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:3887186T>C	uc003bpt.3	+	2	1622	c.861T>C	c.(859-861)CTT>CTC	p.L287L	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	287	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		AAAATATGCTTCGGTTAAAAG	0.438													16	69					0	0	0	0	C	3887186	C	C	3887186	2	2	261	1	0	0	0	0	0	0	0	1	9084	1770	62	5		5	LRRN1	3	3887186	Silent	SNP	T	TCGA-CV-7427-01A-11D-2078-08		3887186	194135244	82	47458											
RAD18	56852	broad.mit.edu	37	chr3	8940660	8940660	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atcctcttctctgtcaggttCcaattcctctggggagtcca	6	14	8	13	0	4	0	1	0	3	0	9	1	8	1	4	3	0	1	4	3	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:8940660C>A	uc003brd.2	-	11	1317	c.1240G>T	c.(1240-1242)GAA>TAA	p.E414*	RAD18_uc003bre.2_RNA	NM_020165	NP_064550	Q9NS91	RAD18_HUMAN	postreplication repair protein hRAD18p	414					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			skin(3)|ovary(2)	5				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		CTGTCAGGTTCCAATTCCTCT	0.368								Rad6_pathway					9	31					1.76689e-08	1.88552e-08	1	0	A	8940660	A	A	8940660	4	1	261	1	0	0	0	0	0	1	0	0	13045	864	30	2	259	2	RAD18	3	8940660	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5053474	8940660	189081770	83	47459											
IRAK2	3656	broad.mit.edu	37	chr3	10264469	10264469	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgccagaggatttcatccGggtggggcagctgacaaagc	9	8	14	10	1	2	2	1	1	1	1	3	3	3	3	2	4	3	2	2	4	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:10264469G>A	uc003bve.1	+	9	1239	c.1163G>A	c.(1162-1164)CGG>CAG	p.R388Q		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	388	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						GATTTCATCCGGGTGGGGCAG	0.527													22	72					0	0	0	0	A	10264469	A	A	10264469	3	1	261	1	0	0	0	0	1	0	0	0	7862	1116	39	1	1197	1	IRAK2	3	10264469	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1323809	10264469	187757961	84	47460											
C3orf19	51244	broad.mit.edu	37	chr3	14706577	14706577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcgttcccggcgctgtatGagaaaggatttgccagatct	8	10	14	9	3	1	2	0	1	1	2	2	4	2	3	2	3	1	3	2	3	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:14706577G>A	uc003byw.2	+	6	619	c.528G>A	c.(526-528)ATG>ATA	p.M176I	C3orf19_uc010hei.1_Missense_Mutation_p.M176I|C3orf19_uc010hej.2_Missense_Mutation_p.M81I	NM_016474	NP_057558	Q6PII3	CC019_HUMAN	hypothetical protein LOC51244	176											0						GGCGCTGTATGAGAAAGGATT	0.473													11	125					0	0	0	0	A	14706577	A	A	14706577	3	1	261	1	0	0	0	0	1	0	0	0	2222	1290	45	2	550	2	C3orf19	3	14706577	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4442108	14706577	183315853	85	47461											
NR1D2	9975	broad.mit.edu	37	chr3	24003755	24003755	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggatacctttatgtataatCaagagcagcaagaaaactca	18	9	7	7	0	2	2	2	0	0	2	2	3	2	3	1	1	4	3	1	1	8	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:24003755C>G	uc003ccs.2	+	5	1124	c.805C>G	c.(805-807)CAA>GAA	p.Q269E	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Missense_Mutation_p.Q194E	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	269					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						TATGTATAATCAAGAGCAGCA	0.423													12	39					0	0	0	0	G	24003755	G	G	24003755	3	3	261	1	0	0	0	0	1	0	0	0	10670	827	29	2	823	2	NR1D2	3	24003755	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	9297178	24003755	174018675	86	47462											
NR1D2	9975	broad.mit.edu	37	chr3	24003916	24003916	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcatctcaatggacagttCaaagggaggaatataatgca	16	8	10	7	0	2	0	2	0	1	0	3	3	2	3	0	3	2	3	0	3	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:24003916C>T	uc003ccs.2	+	5	1285	c.966C>T	c.(964-966)TTC>TTT	p.F322F	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Silent_p.F247F	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	322					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						ATGGACAGTTCAAAGGGAGGA	0.398													9	28					0	0	0	0	T	24003916	T	T	24003916	2	4	261	1	0	0	0	0	0	0	0	1	10670	825	29	2		2	NR1D2	3	24003916	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	161	24003916	174018514	87	47463											
MYRIP	25924	broad.mit.edu	37	chr3	40223839	40223839	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgctctgcccagctggaaGagtgtggacaggctggatga	8	9	15	9	0	2	2	0	1	2	1	2	5	2	5	1	4	3	3	1	4	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:40223839G>A	uc003cka.2	+	9	1137	c.1002G>A	c.(1000-1002)AAG>AAA	p.K334K	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.K334K|MYRIP_uc010hhw.2_Silent_p.K245K|MYRIP_uc011ayz.1_Silent_p.K147K|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	334	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		CCAGCTGGAAGAGTGTGGACA	0.522													9	29					0	0	0	0	A	40223839	A	A	40223839	2	1	261	1	0	0	0	0	0	0	0	1	10153	933	33	2		2	MYRIP	3	40223839	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	16219923	40223839	157798591	88	47464											
PTPN23	25930	broad.mit.edu	37	chr3	47448093	47448093	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatctactacttcgcagcCgtggctcatgtgagggcctg	8	10	12	11	2	2	2	1	1	1	1	3	2	2	2	2	2	3	2	2	2	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:47448093C>G	uc003crf.1	+	8	846	c.750C>G	c.(748-750)GCC>GCG	p.A250A	PTPN23_uc011baw.1_Silent_p.A215A|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Silent_p.A120A	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	250	TPR 1.|BRO1.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACTTCGCAGCCGTGGCTCATG	0.627													9	23					0	0	0	0	G	47448093	G	G	47448093	2	3	261	1	0	0	0	0	0	0	0	1	12853	639	23	3		3	PTPN23	3	47448093	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7224254	47448093	150574337	89	47465											
SCAP	22937	broad.mit.edu	37	chr3	47484421	47484421	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggatgggataggatgcacaGaggagcccatggttgtagaa	12	7	17	5	0	0	2	0	0	0	2	0	6	0	6	1	5	2	3	1	5	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:47484421G>A	uc003crh.1	-	2	318	c.63C>T	c.(61-63)CTC>CTT	p.L21L	SCAP_uc011baz.1_5'UTR|SCAP_uc003crg.2_5'UTR	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	21	Helical; Name=1; (Potential).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		AGGATGCACAGAGGAGCCCAT	0.537													6	29					0	0	0	0	A	47484421	A	A	47484421	2	1	261	1	0	0	0	0	0	0	0	1	13942	929	33	2		2	SCAP	3	47484421	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	36328	47484421	150538009	90	47466											
NAT6	24142	broad.mit.edu	37	chr3	50334679	50334679	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaggtcagcacaagcatcCaggagctcgggtcggcggtg	9	6	16	10	3	1	1	1	1	0	0	4	2	2	2	1	5	3	3	1	5	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:50334679C>A	uc003czi.2	-	2	319	c.216G>T	c.(214-216)CTG>CTT	p.L72L	HYAL3_uc003czc.1_Intron|HYAL3_uc003czd.1_Intron|HYAL3_uc003cze.1_Intron|HYAL3_uc003czf.1_Intron|HYAL3_uc003czg.1_Intron|NAT6_uc003czj.2_Silent_p.L94L|NAT6_uc003czk.3_Silent_p.L72L|NAT6_uc003czl.1_Silent_p.L72L	NM_012191	NP_036323	Q93015	NAT6_HUMAN	N-acetyltransferase 6	72	N-acetyltransferase.					cytoplasm	N-acetyltransferase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CACAAGCATCCAGGAGCTCGG	0.642													9	40					0.000442599	0.000457757	1	0	A	50334679	A	A	50334679	2	1	261	1	0	0	0	0	0	0	0	1	10231	581	21	4		4	NAT6	3	50334679	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2850258	50334679	147687751	91	47467											
CACNA1D	776	broad.mit.edu	37	chr3	53834389	53834389	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagaagaagatgatgtgttCaaagtaattattccacgcct	15	11	9	6	1	1	4	1	1	0	3	2	5	2	4	2	0	0	2	2	0	6	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:53834389C>T	uc003dgv.3	+	41	5200	c.5037C>T	c.(5035-5037)TTC>TTT	p.F1679F	CACNA1D_uc003dgu.3_Silent_p.F1699F|CACNA1D_uc003dgy.3_Silent_p.F1664F|CACNA1D_uc003dgw.3_Silent_p.F1346F|CACNA1D_uc003dgx.1_Silent_p.F855F|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1679	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ATGATGTGTTCAAAGTAATTA	0.468													17	49					0	0	0	0	T	53834389	T	T	53834389	2	4	261	1	0	0	0	0	0	0	0	1	2553	825	29	2		2	CACNA1D	3	53834389	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3499710	53834389	144188041	92	47468											
SLMAP	7871	broad.mit.edu	37	chr3	57857389	57857389	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgctttcaaagagtggcgggGactgcacttttattcatcaa	10	13	10	8	1	3	1	3	0	0	1	3	2	3	2	0	3	2	2	0	3	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:57857389G>A	uc003dje.1	+	12	1418	c.1213G>A	c.(1213-1215)GAC>AAC	p.D405N	SLMAP_uc003djc.1_Intron|SLMAP_uc003djd.1_Missense_Mutation_p.D388N|SLMAP_uc003djf.1_Intron|SLMAP_uc003djg.1_Intron	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	405	Cytoplasmic (Potential).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		GAGTGGCGGGGACTGCACTTT	0.358													9	38					0	0	0	0	A	57857389	A	A	57857389	3	1	261	1	0	0	0	0	1	0	0	0	14813	1174	41	2	1204	2	SLMAP	3	57857389	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4023000	57857389	140165041	93	47469											
DZIP3	9666	broad.mit.edu	37	chr3	108380811	108380811	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctttataaattgcactatCagtgtgaagtaagtattttt	13	17	7	4	0	1	1	1	1	0	0	1	1	1	1	0	0	2	4	0	0	7	9			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:108380811C>T	uc003dxd.2	+	20	2709	c.2287C>T	c.(2287-2289)CAG>TAG	p.Q763*	DZIP3_uc003dxf.1_Nonsense_Mutation_p.Q763*|DZIP3_uc011bhm.1_Nonsense_Mutation_p.Q214*	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	763					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ATTGCACTATCAGTGTGAAGT	0.373													10	23					0	0	0	0	T	108380811	T	T	108380811	4	4	261	1	0	0	0	0	0	1	0	0	4887	827	29	2	2361	2	DZIP3	3	108380811	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	50523422	108380811	89641619	94	47470											
DPPA2	151871	broad.mit.edu	37	chr3	109026903	109026903	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcttgcatcaaaaaggcctCaacagaaacaggaatggaac	17	5	10	9	0	2	1	2	0	0	1	2	3	2	3	1	4	4	2	1	4	6	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:109026903C>G	uc003dxo.2	-	6	881	c.634G>C	c.(634-636)GAG>CAG	p.E212Q		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	212						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						AAAAAGGCCTCAACAGAAACA	0.458													11	15					0	0	0	0	G	109026903	G	G	109026903	3	3	261	1	0	0	0	0	1	0	0	0	4756	835	29	2	274	2	DPPA2	3	109026903	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	646092	109026903	88995527	95	47471											
ARHGAP31	57514	broad.mit.edu	37	chr3	119135106	119135106	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaagtgggaggcaaataGaatgatttcggttcacctgc	13	9	13	6	1	1	3	1	1	0	2	2	5	1	4	1	3	1	2	1	3	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:119135106G>C	uc003ecj.3	+	12	4862	c.4330G>C	c.(4330-4332)GAA>CAA	p.E1444Q		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1444					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						GAGGCAAATAGAATGATTTCG	0.463													14	31					0	0	0	0	C	119135106	C	C	119135106	3	2	261	1	0	0	0	0	1	0	0	0	880	943	33	2	4376	2	ARHGAP31	3	119135106	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	10108203	119135106	78887324	96	47472											
GOLGB1	2804	broad.mit.edu	37	chr3	121410602	121410602	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctctatattggatcagttCtgcatctagcttggcattct	7	18	7	9	0	5	0	1	0	4	0	6	1	5	1	0	2	2	4	0	2	3	8			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:121410602C>G	uc003eei.3	-	14	7720	c.7594G>C	c.(7594-7596)GAA>CAA	p.E2532Q	GOLGB1_uc010hrc.2_Missense_Mutation_p.E2537Q|GOLGB1_uc003eej.3_Missense_Mutation_p.E2498Q	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2532	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TGGATCAGTTCTGCATCTAGC	0.398													51	116					0	0	0	0	G	121410602	G	G	121410602	3	3	261	1	0	0	0	0	1	0	0	0	6602	922	32	2	2221	2	GOLGB1	3	121410602	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2275496	121410602	76611828	97	47473											
GOLGB1	2804	broad.mit.edu	37	chr3	121411229	121411229	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctaaagagttacttaaatCagtcaactggtctttgagac	13	14	7	7	0	4	2	2	1	2	2	4	3	4	2	0	1	2	1	0	1	6	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:121411229C>G	uc003eei.3	-	14	7093	c.6967G>C	c.(6967-6969)GAT>CAT	p.D2323H	GOLGB1_uc010hrc.2_Missense_Mutation_p.D2328H|GOLGB1_uc003eej.3_Missense_Mutation_p.D2289H	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2323	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTACTTAAATCAGTCAACTGG	0.373													24	66					0	0	0	0	G	121411229	G	G	121411229	3	3	261	1	0	0	0	0	1	0	0	0	6602	826	29	2	2848	2	GOLGB1	3	121411229	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	627	121411229	76611201	98	47474											
HEG1	57493	broad.mit.edu	37	chr3	124731790	124731790	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggtcagcgagagctgttttCcagctgtagtctgtacggct	6	12	14	9	2	2	1	1	0	1	1	3	2	3	1	1	2	4	6	1	2	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:124731790C>T	uc003ehs.3	-	6	2701	c.2633G>A	c.(2632-2634)GGA>GAA	p.G878E	HEG1_uc011bke.1_Missense_Mutation_p.G978E	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	878	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GAGCTGTTTTCCAGCTGTAGT	0.507													21	72					0	0	0	0	T	124731790	T	T	124731790	3	4	261	1	0	0	0	0	1	0	0	0	7083	855	30	2	1560	2	HEG1	3	124731790	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3320561	124731790	73290640	99	47475											
TPRA1	131601	broad.mit.edu	37	chr3	127298673	127298673	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagcaggaagatgaggaaGagcacattggggatgagcag	15	4	17	5	0	0	5	0	2	0	3	0	8	0	8	0	4	3	3	0	4	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:127298673G>A	uc003ejl.2	-	2	459	c.168C>T	c.(166-168)CTC>CTT	p.L56L	TPRA1_uc003ejm.2_RNA|TPRA1_uc003ejo.2_Silent_p.L56L|TPRA1_uc010hsk.2_Silent_p.L56L|TPRA1_uc003ejn.2_Silent_p.L56L	NM_016372	NP_057456	Q86W33	TPRA1_HUMAN	G protein-coupled receptor 175 isoform 1	56	Helical; Name=1; (Potential).				aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity				0						AGATGAGGAAGAGCACATTGG	0.582													4	43					0	0	0	0	A	127298673	A	A	127298673	2	1	261	1	0	0	0	0	0	0	0	1	16484	929	33	2		2	TPRA1	3	127298673	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2566883	127298673	70723757	100	47476											
PLXND1	23129	broad.mit.edu	37	chr3	129324855	129324855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtaaccggtgtacgtggcgcCcacgagcaggcggctgcccc	6	5	15	15	5	0	0	0	0	0	0	0	1	0	0	4	4	4	4	4	4	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:129324855C>T	uc003emx.2	-	1	728	c.628G>A	c.(628-630)GGC>AGC	p.G210S		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	210	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TACGTGGCGCCCACGAGCAGG	0.607													3	12					0	0	0	0	T	129324855	T	T	129324855	3	4	261	1	0	0	0	0	1	0	0	0	12182	623	22	4	5293	4	PLXND1	3	129324855	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2026182	129324855	68697575	101	47477											
RASA2	5922	broad.mit.edu	37	chr3	141272764	141272764	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacccttatgcaacagtttCtctagtgggcccttctaggt	7	14	9	11	0	2	1	0	1	2	0	3	1	2	1	2	2	2	2	2	2	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:141272764C>T	uc003etz.1	+	6	593	c.593C>T	c.(592-594)TCT>TTT	p.S198F	RASA2_uc010huq.1_Missense_Mutation_p.S198F|RASA2_uc003eua.1_Missense_Mutation_p.S198F|RASA2_uc011bnc.1_5'UTR	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	198	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						GCAACAGTTTCTCTAGTGGGC	0.323													21	63					0	0	0	0	T	141272764	T	T	141272764	3	4	261	1	0	0	0	0	1	0	0	0	13126	913	32	2	615	2	RASA2	3	141272764	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	11947909	141272764	56749666	102	47478											
SI	6476	broad.mit.edu	37	chr3	164733862	164733862	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagtcaatgtctgtgtactGaacatcctgaaatatccaaa	14	12	7	8	0	2	2	1	2	1	0	4	2	4	2	2	0	2	2	2	0	7	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:164733862G>A	uc003fei.2	-	32	3828	c.3766C>T	c.(3766-3768)CAG>TAG	p.Q1256*		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1256	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCTGTGTACTGAACATCCTGA	0.333										HNSCC(35;0.089)			24	75					0	0	0	0	A	164733862	A	A	164733862	4	1	261	1	0	0	0	0	0	1	0	0	14362	1299	45	2	1785	2	SI	3	164733862	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	23461098	164733862	33288568	103	47479											
SLITRK3	22865	broad.mit.edu	37	chr3	164906954	164906954	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttctcattgaggtctatctgGacaatggcattcaagtgttc	9	15	9	8	0	4	1	2	1	3	0	6	2	4	2	0	3	0	2	0	3	3	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:164906954G>C	uc003fej.3	-	2	2109	c.1665C>G	c.(1663-1665)GTC>GTG	p.V555V	SLITRK3_uc003fek.2_Silent_p.V555V	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	555	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GGTCTATCTGGACAATGGCAT	0.527										HNSCC(40;0.11)			4	50					0	0	0	0	C	164906954	C	C	164906954	2	2	261	1	0	0	0	0	0	0	0	1	14808	1161	41	2		2	SLITRK3	3	164906954	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	173092	164906954	33115476	104	47480											
LRRC31	79782	broad.mit.edu	37	chr3	169572619	169572619	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcagtgacatcacgtcatCtgctgttagtgagcactggt	9	12	10	10	1	4	2	3	2	1	0	4	2	4	2	0	1	2	3	0	1	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:169572619C>G	uc003fgc.1	-	6	1050	c.973G>C	c.(973-975)GAT>CAT	p.D325H	LRRC31_uc010hwp.1_Missense_Mutation_p.D269H	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	325	LRR 4.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			ATCACGTCATCTGCTGTTAGT	0.408													16	63					0	0	0	0	G	169572619	G	G	169572619	3	3	261	1	0	0	0	0	1	0	0	0	9036	913	32	2	701	2	LRRC31	3	169572619	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4665665	169572619	28449811	105	47481											
TTC14	151613	broad.mit.edu	37	chr3	180327993	180327993	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaagaaaagagcactataGaaggtgggaaccaggttctg	15	6	15	5	0	1	3	0	0	1	3	1	5	1	5	1	4	2	2	1	4	7	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:180327993G>T	uc003fkk.2	+	12	2108	c.1976G>T	c.(1975-1977)AGA>ATA	p.R659I	TTC14_uc003fkl.2_3'UTR|TTC14_uc003fkm.2_Intron	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	659							RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GAGCACTATAGAAGGTGGGAA	0.403													9	39					0.000274275	0.000284155	1	0	T	180327993	T	T	180327993	3	4	261	1	0	0	0	0	1	0	0	0	16749	942	33	2	2052	2	TTC14	3	180327993	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	10755374	180327993	17694437	106	47482											
DCUN1D1	54165	broad.mit.edu	37	chr3	182683478	182683478	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaacttactgctgttttttCactagattgtgtgaagatca	11	16	7	7	0	2	3	2	1	0	2	2	3	2	3	0	0	3	2	0	0	4	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:182683478C>T	uc003fld.1	-	2	116	c.67G>A	c.(67-69)GAA>AAA	p.E23K	DCUN1D1_uc011bqn.1_5'UTR	NM_020640	NP_065691	Q96GG9	DCNL1_HUMAN	RP42 homolog	23	UBA-like.					ubiquitin ligase complex	protein binding			ovary(1)	1	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			GCTGTTTTTTCACTAGATTGT	0.323													18	53					0	0	0	0	T	182683478	T	T	182683478	3	4	261	1	0	0	0	0	1	0	0	0	4330	835	29	2	736	2	DCUN1D1	3	182683478	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2355485	182683478	15338952	107	47483											
EIF4G1	1981	broad.mit.edu	37	chr3	184039824	184039824	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaaggaggagaggaactgctCcccccagagagtacccctat	13	5	11	12	0	0	2	0	0	0	2	1	6	1	4	5	3	3	2	5	3	4	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:184039824C>T	uc003fnp.2	+	10	1650	c.1452C>T	c.(1450-1452)CTC>CTT	p.L484L	EIF4G1_uc003fno.1_Silent_p.L425L|EIF4G1_uc010hxw.1_Silent_p.L320L|EIF4G1_uc003fnt.2_Silent_p.L195L|EIF4G1_uc003fnq.2_Silent_p.L397L|EIF4G1_uc003fnr.2_Silent_p.L320L|EIF4G1_uc010hxx.2_Silent_p.L491L|EIF4G1_uc003fns.2_Silent_p.L444L|EIF4G1_uc010hxy.2_Silent_p.L491L|EIF4G1_uc003fnv.3_Silent_p.L484L|EIF4G1_uc003fnu.3_Silent_p.L484L|EIF4G1_uc003fnw.2_Silent_p.L491L|EIF4G1_uc003fnx.2_Silent_p.L288L|EIF4G1_uc003fny.3_Silent_p.L288L	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	484					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGAACTGCTCCCCCCAGAGA	0.418													18	49					0	0	0	0	T	184039824	T	T	184039824	2	4	261	1	0	0	0	0	0	0	0	1	5060	842	30	2		2	EIF4G1	3	184039824	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1356346	184039824	13982606	108	47484											
EIF4G1	1981	broad.mit.edu	37	chr3	184039888	184039888	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaggcagcagcagccactCaaggtaaggtgtggttggac	10	7	16	8	0	1	0	1	0	0	0	1	2	1	2	1	6	3	5	1	6	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:184039888C>G	uc003fnp.2	+	10	1714	c.1516C>G	c.(1516-1518)CAA>GAA	p.Q506E	EIF4G1_uc003fno.1_Missense_Mutation_p.Q447E|EIF4G1_uc010hxw.1_Missense_Mutation_p.Q342E|EIF4G1_uc003fnt.2_Missense_Mutation_p.Q217E|EIF4G1_uc003fnq.2_Missense_Mutation_p.Q419E|EIF4G1_uc003fnr.2_Missense_Mutation_p.Q342E|EIF4G1_uc010hxx.2_Missense_Mutation_p.Q513E|EIF4G1_uc003fns.2_Missense_Mutation_p.Q466E|EIF4G1_uc010hxy.2_Missense_Mutation_p.Q513E|EIF4G1_uc003fnv.3_Missense_Mutation_p.Q506E|EIF4G1_uc003fnu.3_Missense_Mutation_p.Q506E|EIF4G1_uc003fnw.2_Missense_Mutation_p.Q513E|EIF4G1_uc003fnx.2_Missense_Mutation_p.Q310E|EIF4G1_uc003fny.3_Missense_Mutation_p.Q310E	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	506					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGCAGCCACTCAAGGTAAGGT	0.532													14	55					0	0	0	0	G	184039888	G	G	184039888	3	3	261	1	0	0	0	0	1	0	0	0	5060	827	29	2	1546	2	EIF4G1	3	184039888	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	64	184039888	13982542	109	47485											
EIF4G1	1981	broad.mit.edu	37	chr3	184044351	184044351	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctaacaaccagctctttgcaCctggagggcgactgagctgg	9	8	12	12	1	1	1	0	1	1	0	1	3	1	2	2	3	5	3	2	3	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:184044351C>T	uc003fnp.2	+	22	3457	c.3259C>T	c.(3259-3261)CCT>TCT	p.P1087S	EIF4G1_uc003fnt.2_Missense_Mutation_p.P798S|EIF4G1_uc003fnq.2_Missense_Mutation_p.P1000S|EIF4G1_uc003fnr.2_Missense_Mutation_p.P923S|EIF4G1_uc010hxx.2_Missense_Mutation_p.P1094S|EIF4G1_uc003fns.2_Missense_Mutation_p.P1047S|EIF4G1_uc010hxy.2_Missense_Mutation_p.P1094S|EIF4G1_uc003fnv.3_Missense_Mutation_p.P1088S|EIF4G1_uc003fnu.3_Missense_Mutation_p.P1087S|EIF4G1_uc003fnw.2_Missense_Mutation_p.P1094S|EIF4G1_uc003fnx.2_Missense_Mutation_p.P892S|EIF4G1_uc003fny.3_Missense_Mutation_p.P891S|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1087					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCTCTTTGCACCTGGAGGGCG	0.597													18	47					0	0	0	0	T	184044351	T	T	184044351	3	4	261	1	0	0	0	0	1	0	0	0	5060	507	18	4	3337	4	EIF4G1	3	184044351	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4463	184044351	13978079	110	47486											
PCYT1A	5130	broad.mit.edu	37	chr3	195965715	195965715	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgctgctggggctctgcttCgggctgatggcctgcagcat	3	11	15	12	1	1	1	0	1	1	0	2	1	1	1	1	4	5	7	1	4	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:195965715C>T	uc003fwg.2	-	10	1121	c.948G>A	c.(946-948)CCG>CCA	p.P316P	uc003fwf.1_5'Flank|PCYT1A_uc003fwh.2_Silent_p.P316P	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	316						cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	GGCTCTGCTTCGGGCTGATGG	0.587													3	12					0	0	0	0	T	195965715	T	T	195965715	2	4	261	1	0	0	0	0	0	0	0	1	11664	871	31	1		1	PCYT1A	3	195965715	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	11921364	195965715	2056715	111	47487											
PCGF3	10336	broad.mit.edu	37	chr4	755157	755157	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccaggcgaccgtcttgcatCtgaagaagttcatcgccaaa	11	8	9	13	3	3	2	1	1	2	1	4	3	3	2	3	1	1	2	3	1	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:755157C>G	uc011bva.1	+	10	1028	c.553C>G	c.(553-555)CTG>GTG	p.L185V	PCGF3_uc003gbd.1_RNA|PCGF3_uc003gbe.2_Missense_Mutation_p.L185V|PCGF3_uc010ibh.2_Missense_Mutation_p.L185V|PCGF3_uc003gbg.1_Missense_Mutation_p.L151V|PCGF3_uc003gbh.2_Missense_Mutation_p.L151V	NM_006315	NP_006306	Q3KNV8	PCGF3_HUMAN	ring finger protein 3	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	zinc ion binding				0						CGTCTTGCATCTGAAGAAGTT	0.488													18	51					0	0	0	0	G	755157	G	G	755157	3	3	261	1	0	0	0	0	1	0	0	0	11630	912	32	2	575	2	PCGF3	4	755157	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08		755157	190399119	112	47488											
GAK	2580	broad.mit.edu	37	chr4	844827	844827	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggaggagaagccttgattgGacaacagatcttcaaagtcg	13	9	12	7	1	2	3	1	1	1	2	3	6	2	5	1	3	2	0	1	3	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:844827G>A	uc003gbm.3	-	26	3753	c.3554C>T	c.(3553-3555)TCC>TTC	p.S1185F	GAK_uc003gbn.3_Missense_Mutation_p.S1106F|GAK_uc003gbk.3_Intron|GAK_uc010ibi.2_Missense_Mutation_p.S410F|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.S1038F	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1185					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		GCCTTGATTGGACAACAGATC	0.388													25	75					0	0	0	0	A	844827	A	A	844827	3	1	261	1	0	0	0	0	1	0	0	0	6230	1174	41	2	393	2	GAK	4	844827	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	89670	844827	190309449	113	47489											
RGS12	6002	broad.mit.edu	37	chr4	3317944	3317944	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgcccattgcctgggccgtCgcccccaagggtgcggagtg	5	6	15	15	4	0	0	0	0	0	0	1	1	0	1	5	3	2	0	5	3	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:3317944C>T	uc003ggw.2	+	2	951	c.47C>T	c.(46-48)TCG>TTG	p.S16L	RGS12_uc003ggu.2_Missense_Mutation_p.S16L|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Missense_Mutation_p.S16L|RGS12_uc003ggx.1_Missense_Mutation_p.S16L	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	16						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCTGGGCCGTCGCCCCCAAGG	0.607													25	94					0	0	0	0	T	3317944	T	T	3317944	3	4	261	1	0	0	0	0	1	0	0	0	13360	893	31	1	49	1	RGS12	4	3317944	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2473117	3317944	187836332	114	47490											
SLC34A2	10568	broad.mit.edu	37	chr4	25676182	25676182	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcacgctgggctccaacatCggcaccaccaccaccgccat	9	5	7	20	3	1	0	1	0	0	0	3	0	2	0	6	2	1	3	6	2	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:25676182C>T	uc003grr.2	+	12	1470	c.1389C>T	c.(1387-1389)ATC>ATT	p.I463I	SLC34A2_uc003grs.2_Silent_p.I462I|SLC34A2_uc010iev.2_Silent_p.I462I	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	463	Extracellular (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GCTCCAACATCGGCACCACCA	0.592													15	58					0	0	0	0	T	25676182	T	T	25676182	2	4	261	1	0	0	0	0	0	0	0	1	14632	874	31	1		1	SLC34A2	4	25676182	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	22358238	25676182	165478094	115	47491											
SLC10A4	201780	broad.mit.edu	37	chr4	48490651	48490651	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggactgtatgtctggaaacaGgtagtcagaatgtgcagctc	11	10	13	7	0	2	1	1	0	1	1	3	3	2	3	0	3	3	4	0	3	4	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:48490651G>C	uc003gyc.2	+	3	1228	c.1009G>C	c.(1009-1011)GGT>CGT	p.G337R	ZAR1_uc003gyd.2_5'Flank	NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	337	Cytoplasmic (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1						TCTGGAAACAGGTAGTCAGAA	0.443													36	95					0	0	0	0	C	48490651	C	C	48490651	3	2	261	1	0	0	0	0	1	0	0	0	14441	1000	35	4	1019	4	SLC10A4	4	48490651	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	22814469	48490651	142663625	116	47492											
LPHN3	23284	broad.mit.edu	37	chr4	62679581	62679581	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgccaattcaccttgactCtgagctagaaagaccctctg	10	10	7	14	1	3	4	1	2	2	2	4	4	4	4	4	0	1	1	4	0	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:62679581C>G	uc010ihh.2	+	6	1423	c.1250C>G	c.(1249-1251)TCT>TGT	p.S417C	LPHN3_uc003hcq.3_Missense_Mutation_p.S417C|LPHN3_uc003hcs.1_Missense_Mutation_p.S246C	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	417	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						caccttgactctgagctagaa	0.144													7	40					0	0	0	0	G	62679581	G	G	62679581	3	3	261	1	0	0	0	0	1	0	0	0	8967	913	32	2	1272	2	LPHN3	4	62679581	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	14188930	62679581	128474695	117	47493											
SULT1E1	6783	broad.mit.edu	37	chr4	70710039	70710039	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccaggaaatgtatcaatttTatcacctcttttctgatatc	11	17	4	9	0	4	1	2	1	2	0	6	2	5	2	2	1	0	1	2	1	5	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:70710039T>C	uc003heo.2	-	7	725	c.612A>G	c.(610-612)ATA>ATG	p.I204M		NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	204	PAPS.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1						GTATCAATTTTATCACCTCTT	0.343													8	63					0	0	0	0	C	70710039	C	C	70710039	3	2	261	1	0	0	0	0	1	0	0	0	15446	1744	61	5	280	5	SULT1E1	4	70710039	Missense_Mutation	SNP	T	TCGA-CV-7427-01A-11D-2078-08	8030458	70710039	120444237	118	47494											
PPBP	5473	broad.mit.edu	37	chr4	74853901	74853901	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctgcctacaagtctgcaGataagtggcttctcatgccc	8	12	9	12	0	2	1	1	0	2	1	3	1	2	1	2	1	5	3	2	1	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:74853901G>A	uc003hhj.2	-	1	1	c.-79_splice	c.e1-1			NM_002704	NP_002695	P02775	CXCL7_HUMAN	pro-platelet basic protein precursor						chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			CAAGTCTGCAGATAAGTGGCT	0.478													9	19					0	0	0	0	A	74853901	A	A	74853901	5	1	261	1	0	0	0	0	0	0	1	0	12358	957	33	2		2	PPBP	4	74853901	Splice_Site	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4143862	74853901	116300375	119	47495											
CXCL3	2921	broad.mit.edu	37	chr4	74904074	74904074	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actttggatgttcttgaggtGaattccctgcagtgtctgca	7	15	11	8	0	2	2	0	2	2	0	3	3	3	3	1	2	2	3	1	2	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:74904074G>A	uc003hhl.2	-	2	319	c.157C>T	c.(157-159)CAC>TAC	p.H53Y		NM_002090	NP_002081	P19876	CXCL3_HUMAN	chemokine (C-X-C motif) ligand 3	53					immune response|inflammatory response|neutrophil chemotaxis	extracellular space	chemokine activity			central_nervous_system(1)	1	Breast(15;0.00612)		all cancers(17;0.00273)|Lung(101;0.196)			TTCTTGAGGTGAATTCCCTGC	0.607													15	61					0	0	0	0	A	74904074	A	A	74904074	3	1	261	1	0	0	0	0	1	0	0	0	4103	1290	45	2	178	2	CXCL3	4	74904074	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	50173	74904074	116250202	120	47496											
KIAA1109	84162	broad.mit.edu	37	chr4	123109097	123109097	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagccgcaaactctgtgcatCaactttgatgatgctttctt	9	14	7	11	1	3	2	1	2	2	0	3	2	3	2	1	0	5	3	1	0	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:123109097C>G	uc003ieh.2	+	7	720	c.675C>G	c.(673-675)ATC>ATG	p.I225M	KIAA1109_uc003iei.1_Translation_Start_Site	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	225					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CTCTGTGCATCAACTTTGATG	0.358													13	52					0	0	0	0	G	123109097	G	G	123109097	3	3	261	1	0	0	0	0	1	0	0	0	8247	816	29	2	701	2	KIAA1109	4	123109097	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	48205023	123109097	68045179	121	47497											
SPATA5	166378	broad.mit.edu	37	chr4	123844435	123844435	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcggcaacctccgggactctGacggtgaccaacttattaga	10	8	11	12	3	1	3	0	2	1	1	2	4	2	4	3	3	2	1	3	3	4	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:123844435G>A	uc003iez.3	+	1	211	c.138G>A	c.(136-138)CTG>CTA	p.L46L	SPATA5_uc003iey.2_Silent_p.L46L|NUDT6_uc003iew.2_5'Flank|NUDT6_uc003iex.2_5'Flank	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	46					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						CCGGGACTCTGACGGTGACCA	0.587													35	84					0	0	0	0	A	123844435	A	A	123844435	2	1	261	1	0	0	0	0	0	0	0	1	15077	1277	45	2		2	SPATA5	4	123844435	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	735338	123844435	67309841	122	47498											
FAT4	79633	broad.mit.edu	37	chr4	126238052	126238052	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttagacaccgccaccgactcGgacatcggctcaaacggtgt	10	7	10	14	5	1	1	1	0	0	1	3	3	1	2	3	3	1	1	3	3	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:126238052G>T	uc003ifj.3	+	1	486	c.486G>T	c.(484-486)TCG>TCT	p.S162S		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	162	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCACCGACTCGGACATCGGCT	0.617											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	24					0.00909568	0.00929575	1	0	T	126238052	T	T	126238052	2	4	261	1	0	0	0	0	0	0	0	1	5724	1103	39	3		3	FAT4	4	126238052	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2393617	126238052	64916224	123	47499											
SETD7	80854	broad.mit.edu	37	chr4	140468192	140468192	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgtgcggtaatccgtcatCgtccaggtgccctggagaaa	8	8	12	13	4	1	1	1	0	0	1	4	2	3	1	4	3	2	1	4	3	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:140468192C>T	uc003ihw.2	-	2	338	c.52G>A	c.(52-54)GAT>AAT	p.D18N	SETD7_uc003ihx.2_Missense_Mutation_p.D18N	NM_030648	NP_085151	Q8WTS6	SETD7_HUMAN	SET domain-containing protein 7	18					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.156)					AATCCGTCATCGTCCAGGTGC	0.522													13	40					0	0	0	0	T	140468192	T	T	140468192	3	4	261	1	0	0	0	0	1	0	0	0	14201	884	31	1	1076	1	SETD7	4	140468192	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	14230140	140468192	50686084	124	47500											
MAP9	79884	broad.mit.edu	37	chr4	156281397	156281397	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatcaactgttctgtcatCatccataatcagttccgctt	9	15	6	11	1	5	0	4	0	1	0	7	1	7	1	2	1	1	3	2	1	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:156281397C>A	uc003ios.2	-	7	1237	c.973G>T	c.(973-975)GAT>TAT	p.D325Y	MAP9_uc011cin.1_Missense_Mutation_p.D300Y|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.D324Y	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	325	Potential.				cell division|mitosis	cytoplasm|microtubule|spindle		p.D325Y(1)		ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		GTTCTGTCATCATCCATAATC	0.378													13	42					9.31168e-06	9.76433e-06	1	0	A	156281397	A	A	156281397	3	1	261	1	0	0	0	0	1	0	0	0	9323	826	29	2	1002	2	MAP9	4	156281397	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	15813205	156281397	34872879	125	47501											
MTNR1A	4543	broad.mit.edu	37	chr4	187455394	187455394	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatcctcgggtcgtactggaGagtccctgcacggaggttgg	6	9	16	10	3	0	1	0	0	0	1	4	4	2	2	2	5	2	3	2	5	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:187455394G>C	uc003izd.1	-	2	520	c.502C>G	c.(502-504)CTC>GTC	p.L168V		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	168	Extracellular (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TCGTACTGGAGAGTCCCTGCA	0.602													13	60					0	0	0	0	C	187455394	C	C	187455394	3	2	261	1	0	0	0	0	1	0	0	0	10004	942	33	2	554	2	MTNR1A	4	187455394	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	31173997	187455394	3698882	126	47502											
FAT1	2195	broad.mit.edu	37	chr4	187549762	187549763	+	Frame_Shift_Ins	INS	-	A	A																															gtggatctctactgctctgcINSagagtgtagattagtttgtt																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:187549762_187549763insA	uc003izf.2	-	8	4666_4667	c.4478_4479insT	c.(4477-4479)CTGfs	p.L1493fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1493	Extracellular (Potential).|Cadherin 13.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TACTGCTCTGCAGAGTGTAGAT	0.416										HNSCC(5;0.00058)			---	---	---								A	187549763	A	A	187549762	7	5	261	1	0	1	1	0	0	0	0	0	5721	697	25	0	9367	0	FAT1	4	187549762	Frame_Shift_Ins	INS	-	TCGA-CV-7427-01A-11D-2078-08	94368	187549762	3604514	127	47503											
FAT1	2195	broad.mit.edu	37	chr4	187628329	187628329	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgctcatgctgcagctctcGatccagagggcgtgcgatgt	6	10	14	11	3	2	1	1	0	1	1	4	3	3	1	1	1	5	4	1	1	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:187628329G>A	uc003izf.2	-	2	2841	c.2653C>T	c.(2653-2655)CGA>TGA	p.R885*	FAT1_uc010iso.1_Nonsense_Mutation_p.R885*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	885	Extracellular (Potential).|Cadherin 7.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGCAGCTCTCGATCCAGAGGG	0.512										HNSCC(5;0.00058)			13	64					0	0	0	0	A	187628329	A	A	187628329	4	1	261	1	0	0	0	0	0	1	0	0	5721	1066	37	1	11217	1	FAT1	4	187628329	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	78567	187628329	3525947	128	47504											
TARS	6897	broad.mit.edu	37	chr5	33455163	33455163	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctattatgacatgtacctCgaagaagggtaagccatcaa	14	11	8	8	1	2	2	1	1	1	1	3	3	2	2	2	1	2	2	2	1	7	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:33455163C>T	uc003jhy.2	+	5	862	c.567C>T	c.(565-567)CTC>CTT	p.L189L	TARS_uc011cob.1_Silent_p.L177L|TARS_uc010iup.1_Silent_p.L130L|TARS_uc011coc.1_Silent_p.L210L|TARS_uc003jhz.2_Silent_p.L85L|TARS_uc011cod.1_Silent_p.L68L	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	189					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	ACATGTACCTCGAAGAAGGGT	0.388													13	27					0	0	0	0	T	33455163	T	T	33455163	2	4	261	1	0	0	0	0	0	0	0	1	15625	871	31	1		1	TARS	5	33455163	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08		33455163	147460097	129	47505											
NIPBL	25836	broad.mit.edu	37	chr5	36976261	36976261	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accgcccactaaatgctgctCaatgtttgtcgcagcaagaa	12	9	8	12	2	1	1	1	0	0	1	2	1	1	1	2	0	3	5	2	0	5	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:36976261C>G	uc003jkl.3	+	9	1751	c.1252C>G	c.(1252-1254)CAA>GAA	p.Q418E	NIPBL_uc003jkk.3_Missense_Mutation_p.Q418E|NIPBL_uc003jkm.1_Missense_Mutation_p.Q297E	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	418	Gln-rich.				brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AAATGCTGCTCAATGTTTGTC	0.413													21	58					0	0	0	0	G	36976261	G	G	36976261	3	3	261	1	0	0	0	0	1	0	0	0	10482	827	29	2	1282	2	NIPBL	5	36976261	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3521098	36976261	143938999	130	47506											
SFRS12	140890	broad.mit.edu	37	chr5	65459693	65459693	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcagctaaggagttagaaGaagtaatgaagcgagtacga	16	7	13	5	2	0	3	0	1	0	2	0	6	0	4	0	1	4	5	0	1	7	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:65459693G>C	uc003juo.2	+	7	1141	c.481G>C	c.(481-483)GAA>CAA	p.E161Q	SFRS12_uc003jun.2_Missense_Mutation_p.E277Q|SFRS12_uc010iwy.2_Missense_Mutation_p.E161Q	NM_139168	NP_631907	Q8WXA9	SREK1_HUMAN	splicing factor, arginine/serine-rich 12 isoform	161					mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding				0		Lung NSC(167;9.34e-06)|Prostate(74;0.00187)|Ovarian(174;0.0545)|Breast(144;0.0928)|Colorectal(97;0.234)		Lung(70;0.00449)		GGAGTTAGAAGAAGTAATGAA	0.363													18	61					0	0	0	0	C	65459693	C	C	65459693	3	2	261	1	0	0	0	0	1	0	0	0	14232	943	33	2	851	2	SFRS12	5	65459693	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	28483432	65459693	115455567	131	47507											
BDP1	55814	broad.mit.edu	37	chr5	70841044	70841044	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttacacttcctgtgccaGaggtaaaagaatgtacagta	13	11	9	8	0	0	2	0	0	0	2	1	2	1	2	2	1	4	4	2	1	6	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:70841044G>A	uc003kbp.1	+	32	7005	c.6742G>A	c.(6742-6744)GAG>AAG	p.E2248K	BDP1_uc003kbo.2_Missense_Mutation_p.E2248K|BDP1_uc003kbq.1_RNA|BDP1_uc003kbr.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	2248					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TCCTGTGCCAGAGGTAAAAGA	0.328													12	48					0	0	0	0	A	70841044	A	A	70841044	3	1	261	1	0	0	0	0	1	0	0	0	1397	943	33	2	6868	2	BDP1	5	70841044	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5381351	70841044	110074216	132	47508											
PPIP5K2	23262	broad.mit.edu	37	chr5	102472491	102472491	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaggaatccatttgtaatCaatgacttgaatatgcagta	14	13	7	7	0	2	2	2	2	0	0	3	3	3	3	1	1	1	3	1	1	6	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:102472491C>T	uc003kod.3	+	4	885	c.366C>T	c.(364-366)ATC>ATT	p.I122I	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Silent_p.I122I|PPIP5K2_uc010jbo.1_Silent_p.I44I	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	122					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						CATTTGTAATCAATGACTTGA	0.303													42	135					0	0	0	0	T	102472491	T	T	102472491	2	4	261	1	0	0	0	0	0	0	0	1	12393	816	29	2		2	PPIP5K2	5	102472491	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	31631447	102472491	78442769	133	47509											
FBXL17	64839	broad.mit.edu	37	chr5	107700445	107700445	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgctaaaatttacctgcttGagtccttcatcagtgagttt	10	16	7	8	0	2	2	2	2	0	0	3	2	3	2	2	0	3	3	2	0	3	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:107700445G>C	uc011cvc.1	-	3	1775	c.1368C>G	c.(1366-1368)CTC>CTG	p.L456L	FBXL17_uc003kon.3_Silent_p.L58L	NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	456											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		TTACCTGCTTGAGTCCTTCAT	0.343													19	60					0	0	0	0	C	107700445	C	C	107700445	2	2	261	1	0	0	0	0	0	0	0	1	5745	1277	45	2		2	FBXL17	5	107700445	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5227954	107700445	73214815	134	47510											
MCC	4163	broad.mit.edu	37	chr5	112418582	112418582	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagccgttctgtttccacctCaaactctctaatcttgcttt	7	16	4	14	1	4	0	1	0	3	0	6	0	5	0	3	0	3	3	3	0	2	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:112418582C>T	uc003kqj.3	-	9	1719	c.1189G>A	c.(1189-1191)GAG>AAG	p.E397K	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Missense_Mutation_p.E587K|MCC_uc011cwb.1_Missense_Mutation_p.E397K|MCC_uc010jcd.1_Missense_Mutation_p.E359K	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	397					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GTTTCCACCTCAAACTCTCTA	0.478													23	81					0	0	0	0	T	112418582	T	T	112418582	3	4	261	1	0	0	0	0	1	0	0	0	9426	835	29	2	1336	2	MCC	5	112418582	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4718137	112418582	68496678	135	47511											
FBN2	2201	broad.mit.edu	37	chr5	127637197	127637197	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaaaggaactgcactcatCtatgtctgtaagcaaacagg	17	8	8	8	0	3	0	1	0	2	0	3	1	3	1	0	2	4	3	0	2	7	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:127637197C>G	uc003kuu.2	-	47	6362	c.5923G>C	c.(5923-5925)GAT>CAT	p.D1975H		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1975	EGF-like 33; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTGCACTCATCTATGTCTGTA	0.353													26	73					0	0	0	0	G	127637197	G	G	127637197	3	3	261	1	0	0	0	0	1	0	0	0	5735	913	32	2	2891	2	FBN2	5	127637197	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	15218615	127637197	53278063	136	47512											
HSPA4	3308	broad.mit.edu	37	chr5	132439956	132439956	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacttgtagccctataatttCaaagcccaaacccaaagtgg	14	10	6	11	0	1	0	1	0	0	0	1	0	1	0	3	1	4	1	3	1	7	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:132439956C>G	uc003kyj.2	+	19	2632	c.2351C>G	c.(2350-2352)TCA>TGA	p.S784*		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	784					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTATAATTTCAAAGCCCAAA	0.433													11	41					0	0	0	0	G	132439956	G	G	132439956	4	3	261	1	0	0	0	0	0	1	0	0	7451	838	29	2	2425	2	HSPA4	5	132439956	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4802759	132439956	48475304	137	47513											
SMAD5	4090	broad.mit.edu	37	chr5	135496568	135496568	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacctccagtattagtgcctCgtcataatgaattcaatcca	12	13	5	11	1	2	1	2	1	0	0	5	1	4	1	4	0	2	1	4	0	6	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:135496568C>T	uc003lbj.1	+	5	871	c.427C>T	c.(427-429)CGT>TGT	p.R143C	SMAD5_uc003lbk.1_Missense_Mutation_p.R143C|SMAD5_uc003lbl.1_Missense_Mutation_p.R143C	NM_001001419	NP_001001419	Q99717	SMAD5_HUMAN	SMAD family member 5	143					BMP signaling pathway|embryonic pattern specification|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATTAGTGCCTCGTCATAATGA	0.418													22	91					0	0	0	0	T	135496568	T	T	135496568	3	4	261	1	0	0	0	0	1	0	0	0	14825	884	31	1	433	1	SMAD5	5	135496568	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3056612	135496568	45418692	138	47514											
SLC23A1	9963	broad.mit.edu	37	chr5	138707763	138707763	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctggaattgcaatctgatCttttgaacttgaagaaaatc	13	15	7	6	0	3	4	0	3	3	1	4	5	3	5	0	1	2	1	0	1	6	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:138707763C>T	uc003leh.2	-	14	1826	c.1729G>A	c.(1729-1731)GAT>AAT	p.D577N	SLC23A1_uc003leg.2_Missense_Mutation_p.D581N	NM_005847	NP_005838	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (nucleobase	577					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	GCAATCTGATCTTTTGAACTT	0.398													37	138					0	0	0	0	T	138707763	T	T	138707763	3	4	261	1	0	0	0	0	1	0	0	0	14526	913	32	2	71	2	SLC23A1	5	138707763	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3211195	138707763	42207497	139	47515											
UBE2D2	7322	broad.mit.edu	37	chr5	138979957	138979957	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tttctttcttttttctgtagGaattgaatgatctggcacgg	7	19	9	6	1	4	2	0	2	4	0	4	3	4	3	0	3	0	2	0	3	3	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:138979957G>C	uc003ler.2	+	2	651	c.25G>C	c.(25-27)GAA>CAA	p.E9Q	UBE2D2_uc003leq.2_5'UTR	NM_003339	NP_003330	P62837	UB2D2_HUMAN	ubiquitin-conjugating enzyme E2D 2 isoform 1	9					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|protein binding|ubiquitin-protein ligase activity			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTTTCTGTAGGAATTGAATGA	0.348													9	24					0	0	0	0	C	138979957	C	C	138979957	3	2	261	1	0	0	0	0	1	0	0	0	16917	1188	41	2	31	2	UBE2D2	5	138979957	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	272194	138979957	41935303	140	47516											
PCDHB15	56121	broad.mit.edu	37	chr5	140625334	140625334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggggagctagccgagcgggGagcccgggtagtttctgagg	6	6	21	8	3	1	1	0	1	1	0	1	4	1	3	2	6	4	3	2	6	2	3	rs2907300		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:140625334G>A	uc003lje.2	+	1	188	c.188G>A	c.(187-189)GGA>GAA	p.G63E		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	63	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCGAGCGGGGAGCCCGGGTA	0.552													11	40					0	0	0	0	A	140625334	A	A	140625334	3	1	261	1	0	0	0	0	1	0	0	0	11594	1174	41	2	190	2	PCDHB15	5	140625334	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1645377	140625334	40289926	141	47517											
PCDHGA5	56110	broad.mit.edu	37	chr5	140743929	140743929	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acctaggggctggggctgcgGagagctgctgctgcccttca	5	8	16	12	1	1	1	1	0	0	1	1	2	1	1	2	5	5	5	2	5	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:140743929G>A	uc003lju.1	+	1	32	c.32G>A	c.(31-33)GGA>GAA	p.G11E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.G11E	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	11					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGGCTGCGGAGAGCTGCTG	0.582													6	20					0	0	0	0	A	140743929	A	A	140743929	3	1	261	1	0	0	0	0	1	0	0	0	11611	1174	41	2	34	2	PCDHGA5	5	140743929	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	118595	140743929	40171331	142	47518											
SPINK9	643394	broad.mit.edu	37	chr5	147715230	147715230	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgacacttgcaaccatgttCagtgagtatctctgataata	12	13	7	9	0	2	3	1	3	1	0	3	3	2	3	1	0	2	3	1	0	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:147715230C>T	uc003lpe.1	+	1	109	c.54C>T	c.(52-54)TTC>TTT	p.F18F	uc003lpb.1_Intron	NM_001040433	NP_001035523	Q5DT21	ISK9_HUMAN	serine peptidase inhibitor, Kazal type 9	18						extracellular region	protein binding|serine-type endopeptidase inhibitor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACCATGTTCAGTGAGTATC	0.433													10	80					0	0	0	0	T	147715230	T	T	147715230	2	4	261	1	0	0	0	0	0	0	0	1	15132	840	29	2		2	SPINK9	5	147715230	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	6971301	147715230	33200030	143	47519											
ZNF300	91975	broad.mit.edu	37	chr5	150275396	150275396	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagaatgtctttccacattCagtacattcataaggttttt	11	16	7	7	0	3	1	2	0	1	1	4	2	4	1	1	2	1	2	1	2	3	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:150275396C>G	uc003lsy.1	-	6	1672	c.1405G>C	c.(1405-1407)GAA>CAA	p.E469Q	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	469	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTTCCACATTCAGTACATTCA	0.413													12	45					0	0	0	0	G	150275396	G	G	150275396	3	3	261	1	0	0	0	0	1	0	0	0	17898	835	29	2	413	2	ZNF300	5	150275396	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2560166	150275396	30639864	144	47520											
GRIA1	2890	broad.mit.edu	37	chr5	153026577	153026577	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacctccttttgtggggccCtccacgtctgcttcattacg	4	14	9	14	2	2	1	1	1	1	0	4	1	4	1	4	2	2	1	4	2	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:153026577C>T	uc003lva.3	+	3	675	c.310C>T	c.(310-312)CTC>TTC	p.L104F	GRIA1_uc003luy.3_Missense_Mutation_p.L104F|GRIA1_uc003luz.3_Missense_Mutation_p.L9F|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Missense_Mutation_p.L35F|GRIA1_uc011dcy.1_Missense_Mutation_p.L114F|GRIA1_uc011dcz.1_Missense_Mutation_p.L114F|GRIA1_uc010jia.1_Missense_Mutation_p.L84F	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	104	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TTGTGGGGCCCTCCACGTCTG	0.498													29	82					0	0	0	0	T	153026577	T	T	153026577	3	4	261	1	0	0	0	0	1	0	0	0	6806	681	24	4	320	4	GRIA1	5	153026577	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2751181	153026577	27888683	145	47521											
FAM114A2	10827	broad.mit.edu	37	chr5	153390822	153390822	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggcaagtttctctggtttGgaggaaacgtgcagctggga	8	11	15	7	1	1	0	0	0	1	0	2	3	1	3	0	5	3	5	0	5	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:153390822G>A	uc003lvb.2	-	9	1560	c.972C>T	c.(970-972)TCC>TCT	p.S324S	FAM114A2_uc003lvc.2_Silent_p.S324S|FAM114A2_uc003lvd.2_Silent_p.S324S|FAM114A2_uc003lve.2_Silent_p.S140S|FAM114A2_uc011dda.1_Silent_p.S254S	NM_018691	NP_061161	Q9NRY5	F1142_HUMAN	hypothetical protein LOC10827	324							purine nucleotide binding				0						TCTCTGGTTTGGAGGAAACGT	0.368													11	53					0	0	0	0	A	153390822	A	A	153390822	2	1	261	1	0	0	0	0	0	0	0	1	5432	1335	47	4		4	FAM114A2	5	153390822	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	364245	153390822	27524438	146	47522											
KIF4B	285643	broad.mit.edu	37	chr5	154397020	154397020	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtcgaaacatggagcaacaGaataccaacaaaataagcct	20	5	7	9	1	0	1	0	0	0	1	1	3	0	2	2	1	6	1	2	1	8	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:154397020G>C	uc010jih.1	+	1	3761	c.3601G>C	c.(3601-3603)GAA>CAA	p.E1201Q		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1201	Interaction with PRC1 (By similarity).|Globular (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGGAGCAACAGAATACCAACA	0.507													7	25					0	0	0	0	C	154397020	C	C	154397020	3	2	261	1	0	0	0	0	1	0	0	0	8343	943	33	2	3603	2	KIF4B	5	154397020	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1006198	154397020	26518240	147	47523											
GABRA1	2554	broad.mit.edu	37	chr5	161322869	161322869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggcaaaagtgtggttccaGaaaaggtaaatgctttaatg	15	11	11	4	0	0	1	0	0	0	1	1	1	1	1	1	3	1	4	1	3	7	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:161322869G>A	uc010jiw.2	+	10	1522	c.1054G>A	c.(1054-1056)GAA>AAA	p.E352K	GABRA1_uc010jix.2_Missense_Mutation_p.E352K|GABRA1_uc010jiy.2_Missense_Mutation_p.E352K|GABRA1_uc003lyx.3_Missense_Mutation_p.E352K|GABRA1_uc010jiz.2_Missense_Mutation_p.E352K|GABRA1_uc010jja.2_Missense_Mutation_p.E352K|GABRA1_uc010jjb.2_Missense_Mutation_p.E352K	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	352	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TGTGGTTCCAGAAAAGGTAAA	0.393													26	62					0	0	0	0	A	161322869	A	A	161322869	3	1	261	1	0	0	0	0	1	0	0	0	6194	943	33	2	1084	2	GABRA1	5	161322869	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	6925849	161322869	19592391	148	47524											
GABRA1	2554	broad.mit.edu	37	chr5	161324342	161324342	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaagaatagccttcccgCtgctatttggaatctttaac	10	14	7	10	1	2	1	1	0	1	1	3	2	3	2	2	1	3	2	2	1	6	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:161324342C>A	uc010jiw.2	+	11	1753	c.1285C>A	c.(1285-1287)CTG>ATG	p.L429M	GABRA1_uc010jix.2_Missense_Mutation_p.L429M|GABRA1_uc010jiy.2_Missense_Mutation_p.L429M|GABRA1_uc003lyx.3_Missense_Mutation_p.L429M|GABRA1_uc010jiz.2_Missense_Mutation_p.L429M|GABRA1_uc010jja.2_Missense_Mutation_p.L429M|GABRA1_uc010jjb.2_Missense_Mutation_p.L429M	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	429	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	AGCCTTCCCGCTGCTATTTGG	0.428													24	101					7.87624e-14	8.46486e-14	1	0	A	161324342	A	A	161324342	3	1	261	1	0	0	0	0	1	0	0	0	6194	796	28	4	1319	4	GABRA1	5	161324342	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1473	161324342	19590918	149	47525											
DRD1	1812	broad.mit.edu	37	chr5	174869513	174869513	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaagcttattacagaggatGagatggcatatgtcctgctg	13	11	11	6	0	0	2	0	1	0	2	1	4	1	3	1	2	3	3	1	2	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:174869513G>A	uc003mcz.2	-	2	1535	c.590C>T	c.(589-591)TCA>TTA	p.S197L		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	197	Helical; Name=5; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	TACAGAGGATGAGATGGCATA	0.502													13	84					0	0	0	0	A	174869513	A	A	174869513	3	1	261	1	0	0	0	0	1	0	0	0	4778	1294	45	2	754	2	DRD1	5	174869513	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	13545171	174869513	6045747	150	47526											
GPRIN1	114787	broad.mit.edu	37	chr5	176026823	176026823	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggagccaggccgggtcttCagcagtgtccatctgccctc	5	9	12	15	1	3	0	1	0	2	0	5	1	4	1	4	3	3	1	4	3	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:176026823C>T	uc003meo.1	-	2	188	c.13G>A	c.(13-15)GAA>AAA	p.E5K		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	5						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCGGGTCTTCAGCAGTGTCC	0.612													3	16					0	0	0	0	T	176026823	T	T	176026823	3	4	261	1	0	0	0	0	1	0	0	0	6768	835	29	2	3017	2	GPRIN1	5	176026823	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1157310	176026823	4888437	151	47527											
NSD1	64324	broad.mit.edu	37	chr5	176709547	176709547	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcgctatgctcaagaacatGatatcactaatttctatatg	13	15	5	8	1	3	2	2	1	1	1	4	2	3	2	0	0	2	2	0	0	7	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:176709547G>C	uc003mfr.3	+	19	6112	c.5974G>C	c.(5974-5976)GAT>CAT	p.D1992H	NSD1_uc003mft.3_Missense_Mutation_p.D1723H|NSD1_uc011dfx.1_Missense_Mutation_p.D1640H	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1992	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCAAGAACATGATATCACTAA	0.378			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			29	81					0	0	0	0	C	176709547	C	C	176709547	3	2	261	1	0	0	0	0	1	0	0	0	10723	1290	45	2	6044	2	NSD1	5	176709547	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	682724	176709547	4205713	152	47528											
NSD1	64324	broad.mit.edu	37	chr5	176709577	176709577	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttctatatgctcaccctaGacaaagtaagtaatgggaaa	16	11	7	7	0	2	1	1	0	1	1	2	2	2	2	1	1	1	3	1	1	7	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:176709577G>C	uc003mfr.3	+	19	6142	c.6004G>C	c.(6004-6006)GAC>CAC	p.D2002H	NSD1_uc003mft.3_Missense_Mutation_p.D1733H|NSD1_uc011dfx.1_Missense_Mutation_p.D1650H	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2002	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GCTCACCCTAGACAAAGTAAG	0.388			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			23	66					0	0	0	0	C	176709577	C	C	176709577	3	2	261	1	0	0	0	0	1	0	0	0	10723	942	33	2	6074	2	NSD1	5	176709577	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	30	176709577	4205683	153	47529											
SERPINB6	5269	broad.mit.edu	37	chr6	2954925	2954925	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcttggtagaatttttGgcaggaatctctaaaagact	11	14	9	7	0	2	2	0	0	2	2	3	3	2	3	0	3	1	3	0	3	5	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:2954925G>C	uc003muk.2	-	3	2326	c.331C>G	c.(331-333)CAA>GAA	p.Q111E	SERPINB6_uc003mui.2_5'UTR|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Missense_Mutation_p.Q111E|SERPINB6_uc003mum.2_Missense_Mutation_p.Q111E|SERPINB6_uc003mun.2_Missense_Mutation_p.Q111E|SERPINB6_uc003muo.2_Missense_Mutation_p.Q111E	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	111					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	TAGAATTTTTGGCAGGAATCT	0.443													12	42					0	0	0	0	C	2954925	C	C	2954925	3	2	261	1	0	0	0	0	1	0	0	0	14170	1357	47	4	815	4	SERPINB6	6	2954925	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08		2954925	168160142	154	47530											
BMP6	654	broad.mit.edu	37	chr6	7861772	7861772	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatcacggccactagcaatCtgtgggttgtgactccacag	10	9	10	12	1	2	1	1	1	1	0	3	1	3	1	2	2	1	2	2	2	2	2	rs147293908	byFrequency	TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:7861772C>G	uc003mxu.3	+	3	1124	c.946C>G	c.(946-948)CTG>GTG	p.L316V		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	316					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					CACTAGCAATCTGTGGGTTGT	0.502													30	88					0	0	0	0	G	7861772	G	G	7861772	3	3	261	1	0	0	0	0	1	0	0	0	1467	912	32	2	956	2	BMP6	6	7861772	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4906847	7861772	163253295	155	47531											
TFAP2A	7020	broad.mit.edu	37	chr6	10404933	10404933	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccttgttaatagggatggcgGagacggcattgctgttggac	8	11	15	7	2	0	1	0	0	0	1	0	4	0	3	1	5	1	4	1	5	2	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:10404933G>C	uc003myr.2	-	4	824	c.572C>G	c.(571-573)TCC>TGC	p.S191C	TFAP2A_uc003myq.2_Missense_Mutation_p.S185C|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Missense_Mutation_p.S191C|TFAP2A_uc003myt.2_Missense_Mutation_p.S187C|TFAP2A_uc003myu.1_Missense_Mutation_p.S191C	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	191					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGGGATGGCGGAGACGGCATT	0.627													11	52					0	0	0	0	C	10404933	C	C	10404933	3	2	261	1	0	0	0	0	1	0	0	0	15853	1174	41	2	757	2	TFAP2A	6	10404933	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2543161	10404933	160710134	156	47532											
NRSN1	140767	broad.mit.edu	37	chr6	24145891	24145891	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccgattttgtggtggtcgAcacacatgctgtccagttta	8	13	11	9	2	0	0	0	0	0	0	2	2	1	0	2	2	2	2	2	2	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:24145891A>G	uc010jpq.1	+	4	542	c.305A>G	c.(304-306)GAC>GGC	p.D102G		NM_080723	NP_542454	Q8IZ57	NRSN1_HUMAN	neurensin 1	102					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle					0						GTGGTGGTCGACACACATGCT	0.527													34	31					0	0	0	0	G	24145891	G	G	24145891	3	3	261	1	0	0	0	0	1	0	0	0	10716	275	10	5	311	5	NRSN1	6	24145891	Missense_Mutation	SNP	A	TCGA-CV-7427-01A-11D-2078-08	13740958	24145891	146969176	157	47533											
SLC17A3	10786	broad.mit.edu	37	chr6	25862525	25862525	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtcaacaggcagcacctcaGaggaatcattgagctgggat	13	7	12	9	0	3	2	3	1	0	1	3	4	3	4	1	3	3	3	1	3	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:25862525G>C	uc003nfi.3	-	3	349	c.239C>G	c.(238-240)TCT>TGT	p.S80C	SLC17A3_uc003nfk.3_Missense_Mutation_p.S80C|SLC17A3_uc011djz.1_Missense_Mutation_p.S80C|SLC17A3_uc011dka.1_Missense_Mutation_p.S80C	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	80					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						CAGCACCTCAGAGGAATCATT	0.428													5	64					0	0	0	0	C	25862525	C	C	25862525	3	2	261	1	0	0	0	0	1	0	0	0	14483	942	33	2	1297	2	SLC17A3	6	25862525	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1716634	25862525	145252542	158	47534											
HIST1H1A	3024	broad.mit.edu	37	chr6	26017460	26017460	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttttgggtttttttggattCttggaggatttccttgttgc	3	22	12	4	0	1	0	0	0	1	0	2	3	2	3	1	4	1	3	1	4	0	10			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:26017460C>T	uc003nfo.2	-	1	581	c.501G>A	c.(499-501)AAG>AAA	p.K167K		NM_005325	NP_005316	Q02539	H11_HUMAN	histone cluster 1, H1a	167					nucleosome assembly|spermatogenesis	nucleosome|nucleus	DNA binding			ovary(2)	2						TTTTTGGATTCTTGGAGGATT	0.473													41	156					0	0	0	0	T	26017460	T	T	26017460	2	4	261	1	0	0	0	0	0	0	0	1	7161	912	32	2		2	HIST1H1A	6	26017460	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	154935	26017460	145097607	159	47535											
HIST1H3E	8353	broad.mit.edu	37	chr6	26225488	26225488	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctccggccacgggcggcGtgaagaagccccatcgctac	7	4	14	16	6	0	2	0	1	0	1	2	2	1	2	4	3	2	2	4	3	3	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:26225488G>A	uc003nhb.2	+	2	466	c.106G>A	c.(106-108)GTG>ATG	p.V36M	HIST1H3E_uc003nhc.3_Missense_Mutation_p.V36M	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	36					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				CACGGGCGGCGTGAAGAAGCC	0.622													31	24					0	0	0	0	A	26225488	A	A	26225488	3	1	261	1	0	0	0	0	1	0	0	0	7198	1145	40	1	108	1	HIST1H3E	6	26225488	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	208028	26225488	144889579	160	47536											
HIST1H2BK	85236	broad.mit.edu	37	chr6	27114494	27114494	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcggctgcgcttgcgcttCttgccgtccttcttctgcgc	0	15	11	15	5	3	0	0	0	3	0	4	0	4	0	2	1	5	3	2	1	0	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:27114494C>G	uc003nix.1	-	1	126	c.84G>C	c.(82-84)AAG>AAC	p.K28N	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	28					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCTTGCGCTTCTTGCCGTCCT	0.597													20	142					0	0	0	0	G	27114494	G	G	27114494	3	3	261	1	0	0	0	0	1	0	0	0	7189	912	32	2	300	2	HIST1H2BK	6	27114494	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	889006	27114494	144000573	161	47537											
HLA-A	3105	broad.mit.edu	37	chr6	29912344	29912344	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggttctccttggagctgtGatcactggagctgtggtcgc	4	13	14	10	1	2	1	1	1	1	0	4	3	2	3	1	4	2	3	1	4	0	2	rs45513603		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:29912344G>A	uc003nol.2	+	5	963	c.963G>A	c.(961-963)GTG>GTA	p.V321V	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc010jrq.2_Silent_p.V200V|HLA-A_uc003nok.2_Silent_p.V200V|HLA-A_uc003non.2_Silent_p.V321V|HLA-A_uc003noo.2_Silent_p.V321V|HLA-A_uc010jrr.2_Intron|HLA-A_uc003nom.2_Silent_p.V200V|HLA-A_uc010klp.2_Intron|HLA-A_uc011dmc.1_Silent_p.V200V|HLA-A_uc011dmd.1_Silent_p.V200V	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	321	Helical; (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TTGGAGCTGTGATCACTGGAG	0.592									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			29	47					0	0	0	0	A	29912344	A	A	29912344	2	1	261	1	0	0	0	0	0	0	0	1	7234	1277	45	2		2	HLA-A	6	29912344	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2797850	29912344	141202723	162	47538											
NFKBIL1	4795	broad.mit.edu	37	chr6	31525604	31525604	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagctggaggacgagtggcaGgaagtcatggggaggtttga	10	7	20	4	1	1	1	1	1	0	0	1	7	1	5	0	7	1	3	0	7	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:31525604G>A	uc003nub.2	+	3	653	c.534G>A	c.(532-534)CAG>CAA	p.Q178Q	NFKBIL1_uc011dnr.1_Intron|NFKBIL1_uc011dns.1_Silent_p.Q155Q|NFKBIL1_uc011dnt.1_RNA|NFKBIL1_uc003nuc.2_Intron	NM_005007	NP_004998	Q9UBC1	IKBL1_HUMAN	nuclear factor of kappa light polypeptide gene	178					cytoplasmic sequestering of transcription factor		protein binding				0						ACGAGTGGCAGGAAGTCATGG	0.567													4	30					0	0	0	0	A	31525604	A	A	31525604	2	1	261	1	0	0	0	0	0	0	0	1	10435	991	35	4		4	NFKBIL1	6	31525604	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1613260	31525604	139589463	163	47539											
LTB	4050	broad.mit.edu	37	chr6	31548552	31548552	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaccatatcggggtgactGatgttgacgtacaccctctc	8	11	9	13	2	1	3	0	3	1	0	4	3	2	3	3	2	1	2	3	2	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:31548552G>A	uc003nuk.2	-	4	677	c.669C>T	c.(667-669)ATC>ATT	p.I223I	LTB_uc003nul.2_3'UTR	NM_002341	NP_002332	Q06643	TNFC_HUMAN	lymphotoxin-beta isoform a	223	Extracellular (Potential).				cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding				0					Infliximab(DB00065)|Simvastatin(DB00641)	CGGGGTGACTGATGTTGACGT	0.622													6	22					0	0	0	0	A	31548552	A	A	31548552	2	1	261	1	0	0	0	0	0	0	0	1	9120	1280	45	2		2	LTB	6	31548552	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	22948	31548552	139566515	164	47540											
BAT3	7917	broad.mit.edu	37	chr6	31606973	31606973	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggactgtagttggggtcttCctgcagtcgtttttgtatat	5	17	13	6	1	1	0	0	0	1	0	3	1	2	1	1	3	1	5	1	3	3	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:31606973C>T	uc003nvg.3	-	25	3648	c.3334G>A	c.(3334-3336)GAA>AAA	p.E1112K	BAT3_uc003nvf.3_Missense_Mutation_p.E1106K|BAT3_uc003nvh.3_Missense_Mutation_p.E1106K|BAT3_uc003nvi.3_Missense_Mutation_p.E1106K|BAT3_uc011dnw.1_Missense_Mutation_p.E1057K|BAT3_uc011dnx.1_Missense_Mutation_p.E883K	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	1112					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						TTGGGGTCTTCCTGCAGTCGT	0.537													3	19					0	0	0	0	T	31606973	T	T	31606973	3	4	261	1	0	0	0	0	1	0	0	0	1324	864	30	2	68	2	BAT3	6	31606973	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	58421	31606973	139508094	165	47541											
CYP21A2	1589	broad.mit.edu	37	chr6	31974817	31974817	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaatccaggtctccggaggCtgaagcaggccatagagaag	12	5	13	11	1	1	2	0	1	1	1	3	4	2	3	4	4	1	2	4	4	4	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:31974817C>T	uc010jtp.2	+	7	797	c.679C>T	c.(679-681)CTG>TTG	p.L227L	CYP21A2_uc011dpb.1_Silent_p.L197L			P08686	CP21A_HUMAN	SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2; SubName: Full=Cytochrome P450 21-hydroxylase; SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_b; SubName: Full=DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B)); SubName: Full=cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNA;	226					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						TCTCCGGAGGCTGAAGCAGGC	0.627													4	11					0	0	0	0	T	31974817	T	T	31974817	2	4	261	1	0	0	0	0	0	0	0	1	4170	796	28	4		4	CYP21A2	6	31974817	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	367844	31974817	139140250	166	47542											
TAP2	6891	broad.mit.edu	37	chr6	32782246	32782246	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtggacatgaccccagctCtctcctcctgcccattcagg	7	9	8	17	0	2	1	1	1	1	0	5	2	4	2	5	2	2	1	5	2	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:32782246C>T	uc011dqf.1	-	14	2437	c.2315G>A	c.(2314-2316)AGA>AAA	p.R772K	HLA-DOB_uc003oca.2_Missense_Mutation_p.R165K|HLA-DOB_uc011dqg.1_Missense_Mutation_p.R165K	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	Error:Variant_position_missing_in_Q03519_after_alignment					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						GACCCCAGCTCTCTCCTCCTG	0.522													29	98					0	0	0	0	T	32782246	T	T	32782246	3	4	261	1	0	0	0	0	1	0	0	0	15617	913	32	2		2	TAP2	6	32782246	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	807429	32782246	138332821	167	47543											
ZBTB22	9278	broad.mit.edu	37	chr6	33284041	33284041	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcctcttgggaggaagatGagaaatcagtggactccctg	11	9	13	8	0	2	2	1	1	1	2	3	6	3	5	2	3	1	0	2	3	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:33284041G>A	uc003oeb.2	-	2	805	c.653C>T	c.(652-654)TCA>TTA	p.S218L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.S218L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	218					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGAGGAAGATGAGAAATCAGT	0.612													6	39					0	0	0	0	A	33284041	A	A	33284041	3	1	261	1	0	0	0	0	1	0	0	0	17597	1294	45	2	1255	2	ZBTB22	6	33284041	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	501795	33284041	137831026	168	47544											
TREM1	54210	broad.mit.edu	37	chr6	41250194	41250194	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggctccttgggaggctggtaGatcacacactgatacagtcc	9	9	12	11	0	1	2	1	1	0	1	3	3	3	3	2	4	1	3	2	4	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:41250194G>C	uc003oqf.1	-	2	409	c.345C>G	c.(343-345)ATC>ATG	p.I115M	TREM1_uc003oqg.1_Missense_Mutation_p.I115M	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	115	Extracellular (Potential).|Ig-like V-type.				blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	GAGGCTGGTAGATCACACACT	0.537													6	27					0	0	0	0	C	41250194	C	C	41250194	3	2	261	1	0	0	0	0	1	0	0	0	16537	932	33	2	371	2	TREM1	6	41250194	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	7966153	41250194	129864873	169	47545											
PRPH2	5961	broad.mit.edu	37	chr6	42666224	42666224	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagcgacgtctgtaggtagcGcagcccaattgtaatggtca	10	9	12	10	3	2	0	1	0	1	0	2	1	2	0	1	2	3	4	1	2	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:42666224G>A	uc003osk.2	-	3	1136	c.850C>T	c.(850-852)CGC>TGC	p.R284C		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	284	Helical; (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			TGTAGGTAGCGCAGCCCAATT	0.587													11	21					0	0	0	0	A	42666224	A	A	42666224	3	1	261	1	0	0	0	0	1	0	0	0	12639	1087	38	1	194	1	PRPH2	6	42666224	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1416030	42666224	128448843	170	47546											
TDRD6	221400	broad.mit.edu	37	chr6	46660213	46660213	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgaggctgcaataagatgtGaatttgttaaatttcaagac	14	12	10	5	1	1	3	1	1	0	2	1	4	1	3	0	1	1	3	0	1	6	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:46660213G>T	uc003oyj.2	+	1	4348	c.4348G>T	c.(4348-4350)GAA>TAA	p.E1450*	TDRD6_uc010jze.2_Nonsense_Mutation_p.E1444*	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1450					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AATAAGATGTGAATTTGTTAA	0.383													33	109					2.5098e-30	2.73139e-30	1	0	T	46660213	T	T	46660213	4	4	261	1	0	0	0	0	0	1	0	0	15800	1291	45	2	4350	2	TDRD6	6	46660213	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3993989	46660213	124454854	171	47547											
CRISP3	10321	broad.mit.edu	37	chr6	49704110	49704110	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatcacctcttaccatcttCagcatgtttctggcaggggg	8	13	9	11	0	5	0	2	0	3	0	5	0	5	0	2	3	2	3	2	3	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:49704110C>T	uc003ozs.2	-	3	198	c.183G>A	c.(181-183)CTG>CTA	p.L61L		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	61					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TTACCATCTTCAGCATGTTTC	0.438													43	96					0	0	0	0	T	49704110	T	T	49704110	2	4	261	1	0	0	0	0	0	0	0	1	3896	813	29	2		2	CRISP3	6	49704110	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3043897	49704110	121410957	172	47548											
PGK2	5232	broad.mit.edu	37	chr6	49754450	49754450	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagcttggaaagtgatgctcGgaaggcttctattttatctg	9	15	11	6	1	2	1	0	1	2	0	3	3	2	3	0	3	2	3	0	3	5	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:49754450G>A	uc003ozu.2	-	1	558	c.451C>T	c.(451-453)CGA>TGA	p.R151*		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	151					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					AGTGATGCTCGGAAGGCTTCT	0.502													20	52					0	0	0	0	A	49754450	A	A	49754450	4	1	261	1	0	0	0	0	0	1	0	0	11846	1124	39	1	806	1	PGK2	6	49754450	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	50340	49754450	121360617	173	47549											
IL17A	3605	broad.mit.edu	37	chr6	52053869	52053869	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagccgcaatgaggaccctGagagatatccctctgtgatc	10	8	11	12	1	1	4	0	3	1	1	3	6	2	5	3	1	1	2	3	1	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:52053869G>C	uc003pak.1	+	3	292	c.247G>C	c.(247-249)GAG>CAG	p.E83Q		NM_002190	NP_002181	Q16552	IL17_HUMAN	interleukin 17A precursor	83					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity				0	Lung NSC(77;0.116)					TGAGGACCCTGAGAGATATCC	0.502													8	28					0	0	0	0	C	52053869	C	C	52053869	3	2	261	1	0	0	0	0	1	0	0	0	7673	1291	45	2	257	2	IL17A	6	52053869	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2299419	52053869	119061198	174	47550											
GSTA1	2938	broad.mit.edu	37	chr6	52659022	52659022	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catacgggcagaaggaggatCatttcacccaaatctgctat	13	9	9	10	1	3	1	2	0	1	1	3	3	3	3	1	3	2	2	1	3	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:52659022C>T	uc003paz.2	-	5	427	c.315G>A	c.(313-315)ATG>ATA	p.M105I		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	105	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	GAAGGAGGATCATTTCACCCA	0.378													43	108					0	0	0	0	T	52659022	T	T	52659022	3	4	261	1	0	0	0	0	1	0	0	0	6869	826	29	2	365	2	GSTA1	6	52659022	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	605153	52659022	118456045	175	47551											
FAM83B	222584	broad.mit.edu	37	chr6	54806332	54806332	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtaacagttagcccatctCaagagataaatgctccacca	15	9	6	11	0	1	1	1	0	1	1	3	2	2	1	3	0	3	3	3	0	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:54806332C>G	uc003pck.2	+	5	2679	c.2563C>G	c.(2563-2565)CAA>GAA	p.Q855E		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	855										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TAGCCCATCTCAAGAGATAAA	0.438													7	34					0	0	0	0	G	54806332	G	G	54806332	3	3	261	1	0	0	0	0	1	0	0	0	5666	827	29	2	2577	2	FAM83B	6	54806332	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2147310	54806332	116308735	176	47552											
REV3L	5980	broad.mit.edu	37	chr6	111688626	111688626	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaagggggaattactggaGaatcaggggagctataacta	14	7	14	6	0	1	1	1	0	0	1	1	4	1	3	1	5	3	1	1	5	7	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:111688626G>A	uc003puy.3	-	14	6688	c.6365C>T	c.(6364-6366)TCT>TTT	p.S2122F	REV3L_uc003pux.3_Missense_Mutation_p.S2044F|REV3L_uc003puz.3_Missense_Mutation_p.S2044F|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2122					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AATTACTGGAGAATCAGGGGA	0.438								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					19	173					0	0	0	0	A	111688626	A	A	111688626	3	1	261	1	0	0	0	0	1	0	0	0	13305	942	33	2	3103	2	REV3L	6	111688626	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	56882294	111688626	59426441	177	47553											
AIG1	51390	broad.mit.edu	37	chr6	143486275	143486275	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacagagagatgatatacccGaagctgctggataattttat	14	11	10	6	1	0	3	0	1	0	2	0	7	0	4	1	1	3	2	1	1	5	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:143486275G>A	uc003qjh.2	+	3	394	c.354G>A	c.(352-354)CCG>CCA	p.P118P	AIG1_uc003qjf.2_Silent_p.P108P|AIG1_uc003qji.2_Silent_p.P56P|AIG1_uc011edw.1_Silent_p.P118P|AIG1_uc003qjg.2_Silent_p.P118P	NM_016108	NP_057192	Q9NVV5	AIG1_HUMAN	androgen-induced 1	118						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(155;2.34e-05)|GBM - Glioblastoma multiforme(68;0.0246)		TGATATACCCGAAGCTGCTGG	0.358													22	100					0	0	0	0	A	143486275	A	A	143486275	2	1	261	1	0	0	0	0	0	0	0	1	429	1045	37	1		1	AIG1	6	143486275	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	31797649	143486275	27628792	178	47554											
C6orf97	80129	broad.mit.edu	37	chr6	151939129	151939129	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagatgctaggcttgaacgtGaccagccttgctcttcctga	8	11	10	12	1	1	4	0	3	1	1	2	4	2	4	3	1	4	3	3	1	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:151939129G>A	uc003qol.2	+	11	2084	c.1995G>A	c.(1993-1995)GTG>GTA	p.V665V		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	665											0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		GCTTGAACGTGACCAGCCTTG	0.443													5	71					0	0	0	0	A	151939129	A	A	151939129	2	1	261	1	0	0	0	0	0	0	0	1	2385	1277	45	2		2	C6orf97	6	151939129	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	8452854	151939129	19175938	179	47555											
WTAP	9589	broad.mit.edu	37	chr6	160164726	160164726	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taactggcctaagagagtctGaagaaaaactaaagcaacaa	20	6	8	7	0	1	3	0	1	1	2	1	4	1	3	1	1	4	1	1	1	9	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:160164726G>T	uc003qsl.2	+	5	397	c.175G>T	c.(175-177)GAA>TAA	p.E59*	WTAP_uc010kjx.2_Nonsense_Mutation_p.E59*|WTAP_uc003qsk.2_Nonsense_Mutation_p.E59*|WTAP_uc003qsm.1_RNA|WTAP_uc003qsn.2_Nonsense_Mutation_p.E59*	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	59					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		AAGAGAGTCTGAAGAAAAACT	0.363													9	33					2.17888e-05	2.27689e-05	1	0	T	160164726	T	T	160164726	4	4	261	1	0	0	0	0	0	1	0	0	17477	1291	45	2	189	2	WTAP	6	160164726	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	8225597	160164726	10950341	180	47556											
THBS2	7058	broad.mit.edu	37	chr6	169623478	169623478	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagttcctgaagtctgtctCactgatggcattgttttcag	8	15	10	8	0	3	2	2	2	2	0	5	3	4	2	1	1	0	3	1	1	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:169623478C>G	uc003qwt.2	-	19	3114	c.2866G>C	c.(2866-2868)GAG>CAG	p.E956Q		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	956	TSP type-3 8.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		AAGTCTGTCTCACTGATGGCA	0.468													13	67					0	0	0	0	G	169623478	G	G	169623478	3	3	261	1	0	0	0	0	1	0	0	0	15920	835	29	2	672	2	THBS2	6	169623478	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	9458752	169623478	1491589	181	47557											
TBP	6908	broad.mit.edu	37	chr6	170873691	170873691	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acctaaagaccattgcacttCgtgcccgaaacgccgaatat	13	8	7	13	4	0	1	0	0	0	1	1	3	0	1	4	0	3	1	4	0	5	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:170873691C>T	uc003qxt.2	+	4	788	c.556C>T	c.(556-558)CGT>TGT	p.R186C	TBP_uc003qxu.2_Missense_Mutation_p.R186C|TBP_uc011ehf.1_Missense_Mutation_p.R166C	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	186	1.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		CATTGCACTTCGTGCCCGAAA	0.318													11	34					0	0	0	0	T	170873691	T	T	170873691	3	4	261	1	0	0	0	0	1	0	0	0	15710	884	31	1	566	1	TBP	6	170873691	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1250213	170873691	241376	182	47558											
EIF2AK1	27102	broad.mit.edu	37	chr7	6089666	6089666	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccccattttgataaacgtCtggcaaagtactataaaaag	16	10	7	8	1	1	1	0	1	1	0	1	1	1	1	2	1	3	2	2	1	8	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:6089666C>G	uc003spp.2	-	3	434	c.288G>C	c.(286-288)CAG>CAC	p.Q96H	EIF2AK1_uc003spq.2_Missense_Mutation_p.Q96H|EIF2AK1_uc011jwm.1_Intron	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	96					negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		TGATAAACGTCTGGCAAAGTA	0.318													9	35					0	0	0	0	G	6089666	G	G	6089666	3	3	261	1	0	0	0	0	1	0	0	0	5018	912	32	2	1656	2	EIF2AK1	7	6089666	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08		6089666	153048997	183	47559											
RAC1	5879	broad.mit.edu	37	chr7	6426892	6426892	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttacacaaccaatgcatttCctggagaatatatccctact	13	12	5	11	0	0	1	0	0	0	1	2	2	2	1	3	1	4	2	3	1	7	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:6426892C>A	uc003spx.2	+	2	326	c.85C>A	c.(85-87)CCT>ACT	p.P29T	RAC1_uc003spw.2_Missense_Mutation_p.P29T	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	29					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	CAATGCATTTCCTGGAGAATA	0.353													20	54					9.95505e-16	1.07181e-15	1	0	A	6426892	A	A	6426892	3	1	261	1	0	0	0	0	1	0	0	0	13039	855	30	2	91	2	RAC1	7	6426892	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	337226	6426892	152711771	184	47560											
TMEM106B	54664	broad.mit.edu	37	chr7	12254482	12254482	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttgcattcaagcaaagaaGatgcttatgatggagtcaca	14	11	9	7	0	2	3	2	1	0	2	2	4	2	4	0	1	3	3	0	1	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:12254482G>A	uc011jxk.1	+	3	446	c.46G>A	c.(46-48)GAT>AAT	p.D16N	TMEM106B_uc003ssh.2_Missense_Mutation_p.D16N	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	16						integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		AAGCAAAGAAGATGCTTATGA	0.353													11	31					0	0	0	0	A	12254482	A	A	12254482	3	1	261	1	0	0	0	0	1	0	0	0	16087	942	33	2	48	2	TMEM106B	7	12254482	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5827590	12254482	146884181	185	47561											
DNAH11	8701	broad.mit.edu	37	chr7	21678666	21678666	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacttgacattctctcaaaaGgagctcagcctaaacaggta	14	10	7	10	0	3	1	2	1	1	0	4	2	3	2	1	2	4	2	1	2	6	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:21678666G>T	uc003svc.2	+	28	4973	c.4942G>T	c.(4942-4944)GGA>TGA	p.G1648*		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1648	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCTCTCAAAAGGAGCTCAGCC	0.398									Kartagener_syndrome				9	47					3.09899e-07	3.27235e-07	1	0	T	21678666	T	T	21678666	4	4	261	1	0	0	0	0	0	1	0	0	4621	1001	35	4	5052	4	DNAH11	7	21678666	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	9424184	21678666	137459997	186	47562											
STK31	56164	broad.mit.edu	37	chr7	23768842	23768842	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggactacacattccttctGatcaagaagttacccagttt	11	12	8	10	0	2	2	1	1	1	1	3	3	3	3	2	2	2	2	2	2	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:23768842G>C	uc003sws.3	+	6	524	c.457G>C	c.(457-459)GAT>CAT	p.D153H	STK31_uc003swt.3_Missense_Mutation_p.D130H|STK31_uc011jze.1_Missense_Mutation_p.D153H|STK31_uc010kuq.2_Missense_Mutation_p.D130H	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	153							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CATTCCTTCTGATCAAGAAGT	0.328													10	22					0	0	0	0	C	23768842	C	C	23768842	3	2	261	1	0	0	0	0	1	0	0	0	15362	1290	45	2	479	2	STK31	7	23768842	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2090176	23768842	135369821	187	47563											
CHN2	1124	broad.mit.edu	37	chr7	29552289	29552289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaccctgaccaccctgcatGatatgcggtaccaaaagctg	11	7	9	14	1	0	2	0	2	0	0	0	2	0	2	4	1	4	4	4	1	4	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:29552289G>A	uc003szz.2	+	13	1782	c.1345G>A	c.(1345-1347)GAT>AAT	p.D449N	CHN2_uc011jzs.1_Missense_Mutation_p.D524N|CHN2_uc010kva.2_3'UTR|CHN2_uc010kvb.2_RNA|CHN2_uc010kvc.2_Missense_Mutation_p.D414N|CHN2_uc011jzt.1_Missense_Mutation_p.D462N|CHN2_uc010kvd.2_Missense_Mutation_p.D305N|CHN2_uc011jzu.1_Missense_Mutation_p.D434N|CHN2_uc010kvg.2_Missense_Mutation_p.D267N|CHN2_uc010kvh.2_Missense_Mutation_p.D209N|CHN2_uc010kvi.2_Missense_Mutation_p.D241N|CHN2_uc010kve.2_3'UTR|CHN2_uc003taa.2_Missense_Mutation_p.D313N|CHN2_uc010kvf.2_Missense_Mutation_p.D255N|CHN2_uc010kvj.2_Missense_Mutation_p.D222N|CHN2_uc010kvk.2_Missense_Mutation_p.D124N|CHN2_uc010kvl.2_RNA|CHN2_uc010kvm.2_Missense_Mutation_p.D268N|CHN2_uc011jzv.1_Missense_Mutation_p.D242N	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	449	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						CACCCTGCATGATATGCGGTA	0.463													13	49					0	0	0	0	A	29552289	A	A	29552289	3	1	261	1	0	0	0	0	1	0	0	0	3378	1290	45	2	1563	2	CHN2	7	29552289	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5783447	29552289	129586374	188	47564											
CCDC129	223075	broad.mit.edu	37	chr7	31614170	31614170	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acagcattcctgaatggctgGaattttgggagatagatcca	12	11	11	7	0	0	3	0	1	0	2	2	5	2	4	2	3	1	2	2	3	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:31614170G>T	uc003tcj.1	+	7	1405	c.412G>T	c.(412-414)GAA>TAA	p.E138*	CCDC129_uc011kad.1_Nonsense_Mutation_p.E148*|CCDC129_uc003tci.1_Nonsense_Mutation_p.E137*|CCDC129_uc011kae.1_Nonsense_Mutation_p.E164*|CCDC129_uc003tck.1_Nonsense_Mutation_p.E46*	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	138											0						TGAATGGCTGGAATTTTGGGA	0.438													29	102					4.02929e-09	4.31505e-09	1	0	T	31614170	T	T	31614170	4	4	261	1	0	0	0	0	0	1	0	0	2776	1175	41	2	434	2	CCDC129	7	31614170	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2061881	31614170	127524493	189	47565											
UPP1	7378	broad.mit.edu	37	chr7	48147942	48147942	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttcatcaagaagaaactGagcaaggcctgagcgctgcc	13	7	10	11	1	2	4	2	2	0	2	2	4	2	4	2	1	5	2	2	1	5	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:48147942G>T	uc003toj.2	+	10	1450	c.921G>T	c.(919-921)CTG>CTT	p.L307L	UPP1_uc003tok.2_Silent_p.L307L|UPP1_uc003tol.2_Silent_p.L307L|UPP1_uc011kch.1_Silent_p.L100L|UPP1_uc003ton.2_Silent_p.L170L|UPP1_uc003too.2_Silent_p.L170L	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	307					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						AGAAGAAACTGAGCAAGGCCT	0.567													11	30					0.000673444	0.000692948	1	0	T	48147942	T	T	48147942	2	4	261	1	0	0	0	0	0	0	0	1	17080	1277	45	2		2	UPP1	7	48147942	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	16533772	48147942	110990721	190	47566											
EGFR	1956	broad.mit.edu	37	chr7	55241688	55241688	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcttgaaggaaactgaattCaaaaagatcaaagtgctggg	17	9	10	5	0	3	3	2	2	1	1	3	4	3	4	0	2	2	1	0	2	6	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:55241688C>G	uc003tqk.2	+	18	2382	c.2136C>G	c.(2134-2136)TTC>TTG	p.F712L	EGFR_uc010kzg.1_Missense_Mutation_p.F667L|EGFR_uc011kco.1_Missense_Mutation_p.F659L	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	712	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.F712L(2)|p.F712S(1)|p.F712F(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AAACTGAATTCAAAAAGATCA	0.562		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			16	49					0	0	0	0	G	55241688	G	G	55241688	3	3	261	1	0	0	0	0	1	0	0	0	4989	825	29	2	2470	2	EGFR	7	55241688	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7093746	55241688	103896975	191	47567											
PHTF2	57157	broad.mit.edu	37	chr7	77558594	77558594	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agacagatgtggaaaatcatCagattaatccatgtgtgaaa	17	10	9	5	0	2	4	2	1	0	3	3	5	3	5	1	1	0	0	1	1	4	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:77558594C>G	uc003ugs.3	+	11	1414	c.1288C>G	c.(1288-1290)CAG>GAG	p.Q430E	PHTF2_uc003ugp.2_Missense_Mutation_p.Q392E|PHTF2_uc003ugq.3_Missense_Mutation_p.Q392E|PHTF2_uc010ldv.2_Missense_Mutation_p.Q392E|PHTF2_uc003ugt.3_Missense_Mutation_p.Q396E|PHTF2_uc003ugu.3_Missense_Mutation_p.Q392E|PHTF2_uc003ugv.2_Missense_Mutation_p.Q255E|PHTF2_uc010ldw.1_Missense_Mutation_p.Q255E	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						GGAAAATCATCAGATTAATCC	0.388													5	14					0	0	0	0	G	77558594	G	G	77558594	3	3	261	1	0	0	0	0	1	0	0	0	11918	827	29	2	1278	2	PHTF2	7	77558594	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	22316906	77558594	81580069	192	47568											
CACNA2D1	781	broad.mit.edu	37	chr7	81598239	81598239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcccttgaatatatatttCtacagctttgcttaccataa	11	18	3	9	0	1	1	0	1	1	0	2	1	2	1	2	0	4	2	2	0	7	10			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:81598239C>T	uc003uhr.1	-	29	2615	c.2359G>A	c.(2359-2361)GAA>AAA	p.E787K	CACNA2D1_uc011kgy.1_Intron	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	799	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ATATATATTTCTACAGCTTTG	0.269													16	76					0	0	0	0	T	81598239	T	T	81598239	3	4	261	1	0	0	0	0	1	0	0	0	2560	922	32	2	960	2	CACNA2D1	7	81598239	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4039645	81598239	77540424	193	47569											
PCLO	27445	broad.mit.edu	37	chr7	82586178	82586178	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atattccatcggaagaatatCccgtgtcgctcagaccttgg	10	11	9	11	3	1	2	1	0	0	2	5	3	3	3	3	2	0	1	3	2	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:82586178C>T	uc003uhx.2	-	5	4380	c.4091G>A	c.(4090-4092)GGA>GAA	p.G1364E	PCLO_uc003uhv.2_Missense_Mutation_p.G1364E	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1295					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGAAGAATATCCCGTGTCGCT	0.423													6	24					0	0	0	0	T	82586178	T	T	82586178	3	4	261	1	0	0	0	0	1	0	0	0	11637	855	30	2	11438	2	PCLO	7	82586178	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	987939	82586178	76552485	194	47570											
ABCB1	5243	broad.mit.edu	37	chr7	87179592	87179592	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctgcccactctgcaccttCaggttcagacccttcaagat	8	11	7	15	0	5	2	3	0	2	2	5	2	5	2	3	1	2	2	3	1	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:87179592C>G	uc003uiz.1	-	13	1663	c.1245G>C	c.(1243-1245)CTG>CTC	p.L415L	ABCB1_uc011khc.1_Silent_p.L351L	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	415	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCTGCACCTTCAGGTTCAGAC	0.502													8	35					0	0	0	0	G	87179592	G	G	87179592	2	3	261	1	0	0	0	0	0	0	0	1	40	813	29	2		2	ABCB1	7	87179592	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4593414	87179592	71959071	195	47571											
ARPC1B	10095	broad.mit.edu	37	chr7	98992106	98992106	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttgaaggacctcaagatCaaatgacctgtgaggaatat	14	9	10	8	0	2	4	2	3	0	1	2	6	2	6	3	2	0	0	3	2	5	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:98992106C>G	uc003upz.2	+	10	1202	c.1113C>G	c.(1111-1113)ATC>ATG	p.I371M	ARPC1B_uc003uqa.2_Missense_Mutation_p.I371M|ARPC1B_uc003uqb.2_Missense_Mutation_p.I371M|ARPC1B_uc003uqc.2_3'UTR|ARPC1B_uc003uqd.2_Missense_Mutation_p.I183M	NM_005720	NP_005711	O15143	ARC1B_HUMAN	actin related protein 2/3 complex subunit 1B	371					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			ACCTCAAGATCAAATGACCTG	0.572													15	52					0	0	0	0	G	98992106	G	G	98992106	3	3	261	1	0	0	0	0	1	0	0	0	972	816	29	2	1147	2	ARPC1B	7	98992106	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	11812514	98992106	60146557	196	47572											
TRIM4	89122	broad.mit.edu	37	chr7	99489924	99489924	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcgctgtagaaggagacattCccagtcccacgatccaggta	11	7	11	12	2	0	2	0	0	0	2	3	4	3	2	3	2	0	3	3	2	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:99489924C>T	uc003usd.2	-	7	1495	c.1365G>A	c.(1363-1365)GGG>GGA	p.G455G	TRIM4_uc003use.2_Silent_p.G429G|TRIM4_uc011kjc.1_Silent_p.G285G	NM_033017	NP_148977	Q9C037	TRIM4_HUMAN	tripartite motif protein TRIM4 isoform alpha	455	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			ovary(1)|kidney(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				AGGAGACATTCCCAGTCCCAC	0.557													23	102					0	0	0	0	T	99489924	T	T	99489924	2	4	261	1	0	0	0	0	0	0	0	1	16581	842	30	2		2	TRIM4	7	99489924	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	497818	99489924	59648739	197	47573											
C7orf59	389541	broad.mit.edu	37	chr7	99751027	99751027	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccgtctgcatgcagtcatCtggggacctggagaatgatg	8	10	13	10	1	3	2	1	1	2	1	4	4	4	3	2	3	2	2	2	3	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:99751027C>T	uc003utq.2	+	3	155	c.89C>T	c.(88-90)TCT>TTT	p.S30F		NM_001008395	NP_001008396	Q0VGL1	CG059_HUMAN	hypothetical protein LOC389541	30											0						ATGCAGTCATCTGGGGACCTG	0.458													32	114					0	0	0	0	T	99751027	T	T	99751027	3	4	261	1	0	0	0	0	1	0	0	0	2417	913	32	2	99	2	C7orf59	7	99751027	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	261103	99751027	59387636	198	47574											
SRPK2	6733	broad.mit.edu	37	chr7	104783666	104783666	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttctattattttcctttCagcttctcgctccaattctt	5	22	2	12	1	5	0	1	0	4	0	8	0	7	0	2	0	1	2	2	0	3	10			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:104783666C>G	uc003vct.2	-	9	1079	c.892G>C	c.(892-894)GAA>CAA	p.E298Q	SRPK2_uc003vcu.2_Missense_Mutation_p.E298Q|SRPK2_uc003vcv.2_Missense_Mutation_p.E309Q|SRPK2_uc003vcw.1_Missense_Mutation_p.E298Q	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	298	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						ATTTTCCTTTCAGCTTCTCGC	0.408													18	81					0	0	0	0	G	104783666	G	G	104783666	3	3	261	1	0	0	0	0	1	0	0	0	15226	835	29	2	1202	2	SRPK2	7	104783666	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5032639	104783666	54354997	199	47575											
C7orf53	286006	broad.mit.edu	37	chr7	112124970	112124970	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacttaaacaaactaaacctCtgtccagccggatcgcagca	14	7	7	13	2	1	0	0	0	1	0	3	2	2	1	3	1	5	2	3	1	5	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:112124970C>T	uc011kmq.1	+	2	234	c.99C>T	c.(97-99)CTC>CTT	p.L33L	C7orf53_uc003vgl.2_RNA|C7orf53_uc003vgm.2_Silent_p.L33L	NM_001134468	NP_001127940	Q8N8F7	CG053_HUMAN	hypothetical protein LOC286006	33						integral to membrane				ovary(1)	1						AACTAAACCTCTGTCCAGCCG	0.478													25	74					0	0	0	0	T	112124970	T	T	112124970	2	4	261	1	0	0	0	0	0	0	0	1	2413	900	32	2		2	C7orf53	7	112124970	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7341304	112124970	47013693	200	47576											
NDUFA5	4698	broad.mit.edu	37	chr7	123185709	123185709	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accgccttgaagttggtcttCtaattttttaacatctggtt	8	18	7	8	1	3	1	0	1	3	0	3	1	3	1	2	2	1	2	2	2	3	8			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:123185709C>T	uc003vks.2	-	4	314	c.205G>A	c.(205-207)GAA>AAA	p.E69K	NDUFA5_uc003vkr.2_RNA	NM_005000	NP_004991	Q16718	NDUA5_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	69					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	AGTTGGTCTTCTAATTTTTTA	0.313													13	51					0	0	0	0	T	123185709	T	T	123185709	3	4	261	1	0	0	0	0	1	0	0	0	10322	922	32	2	153	2	NDUFA5	7	123185709	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	11060739	123185709	35952954	201	47577											
TMEM209	84928	broad.mit.edu	37	chr7	129841908	129841908	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatttgggttgctgccagatCatgtggaggcgtagtctgta	7	13	15	6	1	2	1	1	0	1	1	2	3	2	2	1	3	2	4	1	3	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:129841908C>T	uc003vpn.2	-	5	478	c.355G>A	c.(355-357)GAT>AAT	p.D119N	TMEM209_uc010lmc.1_Missense_Mutation_p.D119N|TMEM209_uc003vpo.2_Missense_Mutation_p.D119N	NM_032842	NP_116231	Q96SK2	TM209_HUMAN	transmembrane protein 209	119						integral to membrane				ovary(2)|large_intestine(1)	3	Melanoma(18;0.0435)					GCTGCCAGATCATGTGGAGGC	0.428													7	29					0	0	0	0	T	129841908	T	T	129841908	3	4	261	1	0	0	0	0	1	0	0	0	16200	826	29	2	1374	2	TMEM209	7	129841908	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	6656199	129841908	29296755	202	47578											
WEE2	494551	broad.mit.edu	37	chr7	141408625	141408625	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcctattgtgaggagactGagattgaagggcagaagaaa	14	10	13	4	0	0	6	0	3	0	4	1	8	1	6	1	2	0	1	1	2	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:141408625G>A	uc003vwn.2	+	1	473	c.67G>A	c.(67-69)GAG>AAG	p.E23K	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	23					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					TGAGGAGACTGAGATTGAAGG	0.443													24	73					0	0	0	0	A	141408625	A	A	141408625	3	1	261	1	0	0	0	0	1	0	0	0	17413	1291	45	2	69	2	WEE2	7	141408625	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	11566717	141408625	17730038	203	47579											
TRPV5	56302	broad.mit.edu	37	chr7	142605909	142605909	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctggtcatcctccttgtctGagttcttgaacacttccaca	7	14	6	14	0	3	2	1	2	2	0	6	2	6	2	4	1	1	1	4	1	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:142605909G>C	uc003wby.1	-	15	2225	c.1961C>G	c.(1960-1962)TCA>TGA	p.S654*		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	654	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CTCCTTGTCTGAGTTCTTGAA	0.522													9	34					0	0	0	0	C	142605909	C	C	142605909	4	2	261	1	0	0	0	0	0	1	0	0	16666	1294	45	2	232	2	TRPV5	7	142605909	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1197284	142605909	16532754	204	47580											
SSPO	23145	broad.mit.edu	37	chr7	149482281	149482281	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgggcagtggtacctgccCaacgccaccatccaggaaga	11	5	12	13	1	0	1	0	0	0	1	1	2	1	2	5	3	3	2	5	3	3	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:149482281C>G	uc010lpk.2	+	21	2955	c.2955C>G	c.(2953-2955)CCC>CCG	p.P985P	SSPO_uc010lpl.1_Missense_Mutation_p.P321R	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	985					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGTACCTGCCCAACGCCACCA	0.612													11	50					0	0	0	0	G	149482281	G	G	149482281	2	3	261	1	0	0	0	0	0	0	0	1	15255	581	21	4		4	SSPO	7	149482281	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	6876372	149482281	9656382	205	47581											
GBX1	2636	broad.mit.edu	37	chr7	150845999	150845999	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgtcggcttttccccccagGagctgtgacccctgctgtca	4	10	10	17	2	1	1	1	1	0	0	3	2	2	2	6	2	2	3	6	2	0	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:150845999G>A	uc011kvg.1	-	2	1001	c.769C>T	c.(769-771)CCT>TCT	p.P257S		NM_001098834	NP_001092304	Q14549	GBX1_HUMAN	gastrulation brain homeo box 1	257						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTCCCCCCAGGAGCTGTGACC	0.582													26	69					0	0	0	0	A	150845999	A	A	150845999	3	1	261	1	0	0	0	0	1	0	0	0	6315	1174	41	2	325	2	GBX1	7	150845999	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1363718	150845999	8292664	206	47582											
XKR6	286046	broad.mit.edu	37	chr8	10755509	10755509	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcatagaggagtggtccgtCtcgatatcgaatgcctactg	9	11	11	10	3	2	1	1	0	1	1	5	4	3	2	2	2	2	0	2	2	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:10755509C>G	uc003wtk.1	-	3	1906	c.1879G>C	c.(1879-1881)GAC>CAC	p.D627H		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	627						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		AGTGGTCCGTCTCGATATCGA	0.463													20	34					0	0	0	0	G	10755509	G	G	10755509	3	3	261	1	0	0	0	0	1	0	0	0	17503	913	32	2	50	2	XKR6	8	10755509	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08		10755509	135608513	207	47583											
FGL1	2267	broad.mit.edu	37	chr8	17731930	17731930	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acagtccatcctcctccatcGgacatgtcacaataaacaga	14	8	5	14	1	1	1	1	0	0	1	6	2	5	2	4	1	1	0	4	1	3	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:17731930G>A	uc003wxx.2	-	5	669	c.345C>T	c.(343-345)TCC>TCT	p.S115S	FGL1_uc003wxy.2_Silent_p.S115S|FGL1_uc003wxz.2_Silent_p.S115S|FGL1_uc003wya.2_Silent_p.S115S|FGL1_uc003wyb.2_Silent_p.S115S|FGL1_uc003wyc.2_Silent_p.S115S|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Silent_p.S165S|FGL1_uc003wyf.2_Silent_p.S85S	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	115	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		CTCCTCCATCGGACATGTCAC	0.383													29	44					0	0	0	0	A	17731930	A	A	17731930	2	1	261	1	0	0	0	0	0	0	0	1	5904	1103	39	1		1	FGL1	8	17731930	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	6976421	17731930	128632092	208	47584											
NKX3-1	4824	broad.mit.edu	37	chr8	23538827	23538827	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accagggaggcccgggagaaGgcctcctctttcagggccgg	7	5	16	13	2	2	1	1	0	1	1	3	3	3	2	5	6	0	0	5	6	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:23538827G>C	uc011kzx.1	-	2	660	c.612C>G	c.(610-612)GCC>GCG	p.A204A	NKX3-1_uc003xdv.1_Intron	NM_006167	NP_006158	Q99801	NKX31_HUMAN	NK3 homeobox 1	204					negative regulation of estrogen receptor binding|negative regulation of transcription, DNA-dependent|positive regulation of cell division|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	nucleus	estrogen receptor activity|estrogen receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region sequence-specific DNA binding				0		Prostate(55;0.114)		Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)|BRCA - Breast invasive adenocarcinoma(99;0.0708)		CCCGGGAGAAGGCCTCCTCTT	0.562													4	44					0	0	0	0	C	23538827	C	C	23538827	2	2	261	1	0	0	0	0	0	0	0	1	10509	987	35	4		4	NKX3-1	8	23538827	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5806897	23538827	122825195	209	47585											
GPR124	25960	broad.mit.edu	37	chr8	37687368	37687368	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acccctctgcccaccctgcaGggacttgggcaccgagttcc	6	7	10	18	1	1	0	0	0	1	0	2	2	2	1	6	2	2	3	6	2	0	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:37687368G>T	uc003xkj.2	+	6	918	c.555_splice	c.e6-1	p.V185_splice	GPR124_uc010lvy.2_Splice_Site_p.V185_splice	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor						central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CCACCCTGCAGGGACTTGGGC	0.667													11	39					5.50884e-06	5.78667e-06	1	0	T	37687368	T	T	37687368	5	4	261	1	0	0	0	0	0	0	1	0	6676	1014	35	4	555	4	GPR124	8	37687368	Splice_Site	SNP	G	TCGA-CV-7427-01A-11D-2078-08	14148541	37687368	108676654	210	47586											
SNAI2	6591	broad.mit.edu	37	chr8	49832516	49832516	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaaacgccttgccgcagatCttgcaaacacaaggtaatgt	14	8	9	10	2	1	1	0	0	1	1	1	2	1	1	2	1	4	3	2	1	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:49832516C>G	uc003xqp.2	-	2	728	c.564G>C	c.(562-564)AAG>AAC	p.K188N		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	188	C2H2-type 3.				canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				TGCCGCAGATCTTGCAAACAC	0.458													9	72					0	0	0	0	G	49832516	G	G	49832516	3	3	261	1	0	0	0	0	1	0	0	0	14891	912	32	2	250	2	SNAI2	8	49832516	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	12145148	49832516	96531506	211	47587											
SGK3	23678	broad.mit.edu	37	chr8	67759505	67759505	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaagtttgaggccaggagtGagtcttacagcctggtccat	9	11	12	9	0	1	2	0	2	1	0	2	3	2	3	3	3	2	1	3	3	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:67759505G>C	uc003xwr.2	+	15	1451	c.1152G>C	c.(1150-1152)GTG>GTC	p.V384V	SGK3_uc003xwp.2_Silent_p.V378V|SGK3_uc003xwt.2_Silent_p.V384V|SGK3_uc003xwu.2_Silent_p.V352V	NM_001033578	NP_001028750	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase 3 isoform	384	Protein kinase.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			ovary(1)|large_intestine(1)|lung(1)|breast(1)	4	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GGCCAGGAGTGAGTCTTACAG	0.408													46	56					0	0	0	0	C	67759505	C	C	67759505	2	2	261	1	0	0	0	0	0	0	0	1	14277	1277	45	2		2	SGK3	8	67759505	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	17926989	67759505	78604517	212	47588											
LRRC67	286187	broad.mit.edu	37	chr8	67926687	67926687	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccagtttctttaatgacctGaggttctctatacatgaaat	11	16	6	8	0	2	3	0	3	2	0	4	3	3	3	2	1	1	2	2	1	4	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:67926687G>C	uc003xxc.2	-	3	415	c.270C>G	c.(268-270)CTC>CTG	p.L90L		NM_001013626	NP_001013648	Q7Z4L9	LRC67_HUMAN	leucine rich repeat containing 67	90	LRR 3.										0						TTAATGACCTGAGGTTCTCTA	0.289													12	68					0	0	0	0	C	67926687	C	C	67926687	2	2	261	1	0	0	0	0	0	0	0	1	9069	1277	45	2		2	LRRC67	8	67926687	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	167182	67926687	78437335	213	47589											
CSPP1	79848	broad.mit.edu	37	chr8	68005835	68005835	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtttctcaggggtaaggaaGaatccagtgaaaagttcagg	14	9	13	5	0	2	2	2	1	1	1	4	3	3	3	1	4	0	3	1	4	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:68005835G>C	uc003xxi.2	+	7	605	c.574G>C	c.(574-576)GAA>CAA	p.E192Q	CSPP1_uc003xxg.1_Missense_Mutation_p.E184Q|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.E157Q|CSPP1_uc003xxk.2_5'UTR	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	192						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			GGGTAAGGAAGAATCCAGTGA	0.338													31	40					0	0	0	0	C	68005835	C	C	68005835	3	2	261	1	0	0	0	0	1	0	0	0	3979	943	33	2	600	2	CSPP1	8	68005835	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	79148	68005835	78358187	214	47590											
C8orf34	116328	broad.mit.edu	37	chr8	69633646	69633646	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaggagggtgacgaatttGagaaagcatctaaactaaca	16	8	12	5	1	1	2	0	2	1	1	1	6	1	4	0	3	3	1	0	3	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:69633646G>C	uc010lyz.2	+	10	1169	c.1120G>C	c.(1120-1122)GAG>CAG	p.E374Q	C8orf34_uc003xyb.2_Missense_Mutation_p.E349Q	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	374					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			TGACGAATTTGAGAAAGCATC	0.269													12	20					0	0	0	0	C	69633646	C	C	69633646	3	2	261	1	0	0	0	0	1	0	0	0	2434	1291	45	2	1079	2	C8orf34	8	69633646	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1627811	69633646	76730376	215	47591											
ZFHX4	79776	broad.mit.edu	37	chr8	77766385	77766385	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccaaaacctgaatatcccGcagaaaagccaaagcagagt	17	5	7	12	1	0	3	0	1	0	2	2	3	2	3	4	0	3	2	4	0	7	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:77766385G>A	uc003yav.2	+	10	7480	c.7093G>A	c.(7093-7095)GCA>ACA	p.A2365T	ZFHX4_uc003yau.1_Missense_Mutation_p.A2410T|ZFHX4_uc003yaw.1_Missense_Mutation_p.A2365T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2365	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A2394T(1)		ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGAATATCCCGCAGAAAAGCC	0.552										HNSCC(33;0.089)			3	12					0	0	0	0	A	77766385	A	A	77766385	3	1	261	1	0	0	0	0	1	0	0	0	17702	1087	38	1	7262	1	ZFHX4	8	77766385	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	8132739	77766385	68597637	216	47592											
PAG1	55824	broad.mit.edu	37	chr8	81899695	81899695	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggctgaacatctccttgtCtgaaggctgaaaacaaaaac	15	8	8	10	1	2	3	0	3	2	0	3	3	2	3	1	2	3	2	1	2	6	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:81899695C>G	uc003ybz.2	-	6	895	c.184G>C	c.(184-186)GAC>CAC	p.D62H		NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid	62	Cytoplasmic (Potential).				epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			ATCTCCTTGTCTGAAGGCTGa	0.428													7	66					0	0	0	0	G	81899695	G	G	81899695	3	3	261	1	0	0	0	0	1	0	0	0	11442	913	32	2	1130	2	PAG1	8	81899695	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4133310	81899695	64464327	217	47593											
RBM12B	389677	broad.mit.edu	37	chr8	94746486	94746486	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccggaaatgctcctggggtGactgcctgaagtcctcctca	7	10	11	13	1	1	2	1	2	0	0	5	3	5	3	5	3	2	1	5	3	2	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:94746486G>A	uc003yfz.2	-	3	2346	c.2153C>T	c.(2152-2154)TCA>TTA	p.S718L		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	718							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CTCCTGGGGTGACTGCCTGAA	0.627													7	162					0	0	0	0	A	94746486	A	A	94746486	3	1	261	1	0	0	0	0	1	0	0	0	13179	1294	45	2	856	2	RBM12B	8	94746486	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	12846791	94746486	51617536	218	47594											
PTDSS1	9791	broad.mit.edu	37	chr8	97299316	97299316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatttcgagcaggttaaatCtctaatgtattggctagatc	12	14	9	6	1	1	1	0	0	1	1	4	3	1	1	0	2	1	4	0	2	6	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:97299316C>T	uc003yht.1	+	4	485	c.383C>T	c.(382-384)TCT>TTT	p.S128F	PTDSS1_uc003yhu.1_Intron	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	128					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	CAGGTTAAATCTCTAATGTAT	0.433													31	185					0	0	0	0	T	97299316	T	T	97299316	3	4	261	1	0	0	0	0	1	0	0	0	12798	913	32	2	397	2	PTDSS1	8	97299316	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2552830	97299316	49064706	219	47595											
VPS13B	157680	broad.mit.edu	37	chr8	100779029	100779029	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagcttggaatactgggatGaactccagaaggtttttgtt	10	14	12	5	0	0	2	0	1	0	1	1	4	1	4	1	3	3	4	1	3	5	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:100779029G>A	uc003yiv.2	+	40	7264	c.7153G>A	c.(7153-7155)GAA>AAA	p.E2385K	VPS13B_uc003yiw.2_Missense_Mutation_p.E2360K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2385					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATACTGGGATGAACTCCAGAA	0.318													14	36					0	0	0	0	A	100779029	A	A	100779029	3	1	261	1	0	0	0	0	1	0	0	0	17258	1291	45	2	7501	2	VPS13B	8	100779029	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3479713	100779029	45584993	220	47596											
FZD6	8323	broad.mit.edu	37	chr8	104337587	104337587	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaaatttatgattcgaattgGagtcttcagcggcttgtatc	10	15	10	6	2	2	1	1	1	1	0	4	4	2	2	0	2	1	2	0	2	4	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:104337587G>C	uc003ylh.2	+	4	1537	c.1253G>C	c.(1252-1254)GGA>GCA	p.G418A	FZD6_uc003yli.2_Missense_Mutation_p.G418A|FZD6_uc003ylj.2_Missense_Mutation_p.G418A|FZD6_uc011lhn.1_Missense_Mutation_p.G384A|FZD6_uc011lho.1_Missense_Mutation_p.G113A|FZD6_uc011lhp.1_Missense_Mutation_p.G363A	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	418	Helical; Name=6; (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			ATTCGAATTGGAGTCTTCAGC	0.403													26	157					0	0	0	0	C	104337587	C	C	104337587	3	2	261	1	0	0	0	0	1	0	0	0	6168	1174	41	2	1263	2	FZD6	8	104337587	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3558558	104337587	42026435	221	47597											
TAF2	6873	broad.mit.edu	37	chr8	120809951	120809951	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacttcaacataagcctcatCaatgaagacagtcttaaaac	17	9	4	11	0	4	2	3	1	1	1	4	2	4	2	1	0	3	0	1	0	6	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:120809951C>T	uc003you.2	-	7	1198	c.928G>A	c.(928-930)GAT>AAT	p.D310N		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	310					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TAAGCCTCATCAATGAAGACA	0.353													6	75					0	0	0	0	T	120809951	T	T	120809951	3	4	261	1	0	0	0	0	1	0	0	0	15590	826	29	2	2751	2	TAF2	8	120809951	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	16472364	120809951	25554071	222	47598											
SNTB1	6641	broad.mit.edu	37	chr8	121823703	121823703	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgttctccttgccccccttGatgctgatccccagcccgcc	3	12	7	19	1	1	2	0	2	1	0	3	2	2	2	8	0	3	2	8	0	0	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:121823703G>C	uc010mdg.2	-	1	607	c.381C>G	c.(379-381)ATC>ATG	p.I127M	SNTB1_uc003ype.2_Missense_Mutation_p.I127M	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	127	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			TGCCCCCCTTGATGCTGATCC	0.632													10	20					0	0	0	0	C	121823703	C	C	121823703	3	2	261	1	0	0	0	0	1	0	0	0	14936	1280	45	2	1263	2	SNTB1	8	121823703	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1013752	121823703	24540319	223	47599											
FLJ43860	389690	broad.mit.edu	37	chr8	142477621	142477621	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagatgaggtcgctcaactCtgccagtgtgagctgctgca	8	9	12	12	1	2	3	1	2	1	1	3	3	2	3	2	1	5	4	2	1	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:142477621C>G	uc003ywi.2	-	18	2281	c.2200G>C	c.(2200-2202)GAG>CAG	p.E734Q	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	734							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TCGCTCAACTCTGCCAGTGTG	0.667													10	41					0	0	0	0	G	142477621	G	G	142477621	3	3	261	1	0	0	0	0	1	0	0	0	5962	922	32	2	1808	2	FLJ43860	8	142477621	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	20653918	142477621	3886401	224	47600											
FOXD4	2298	broad.mit.edu	37	chr9	117889	117889	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgccaaactctgaggggtcGctcgggccgccgccgccctc	4	6	14	17	5	1	1	0	1	1	0	4	1	1	1	5	3	2	1	5	3	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:117889G>A	uc003zfz.2	-	1	529	c.231C>T	c.(229-231)AGC>AGT	p.S77S		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	77					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTGAGGGGTCGCTCGGGCCGC	0.706													26	105					0	0	0	0	A	117889	A	A	117889	2	1	261	1	0	0	0	0	0	0	0	1	6031	1078	38	1		1	FOXD4	9	117889	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08		117889	141095542	225	47601											
SLC24A2	25769	broad.mit.edu	37	chr9	19619622	19619622	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtgtatcatgagttggaaGatgctattcctcatgagact	10	14	11	6	0	2	3	2	2	0	2	3	5	3	4	1	1	1	3	1	1	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:19619622G>C	uc003zoa.1	-	3	1100	c.1038C>G	c.(1036-1038)ATC>ATG	p.I346M	SLC24A2_uc003zob.1_Missense_Mutation_p.I346M	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	346	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TGAGTTGGAAGATGCTATTCC	0.507													16	105					0	0	0	0	C	19619622	C	C	19619622	3	2	261	1	0	0	0	0	1	0	0	0	14530	932	33	2	979	2	SLC24A2	9	19619622	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	19501733	19619622	121593809	226	47602											
IFNA8	3445	broad.mit.edu	37	chr9	21409280	21409280	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actcacagcctgggtaacagGagggccttgatactcctggc	9	8	12	12	0	1	1	1	1	0	0	2	2	2	2	3	4	3	1	3	4	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:21409280G>A	uc003zpc.1	+	1	135	c.105G>A	c.(103-105)AGG>AGA	p.R35R		NM_002170	NP_002161	P32881	IFNA8_HUMAN	interferon, alpha 8 precursor	35					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		TGGGTAACAGGAGGGCCTTGA	0.498													30	85					0	0	0	0	A	21409280	A	A	21409280	2	1	261	1	0	0	0	0	0	0	0	1	7582	1165	41	2		2	IFNA8	9	21409280	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1789658	21409280	119804151	227	47603											
DNAJA1	3301	broad.mit.edu	37	chr9	33038791	33038791	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgatgagatggaccaagtaGaactggtggactttgatcca	12	10	12	7	0	0	4	0	3	0	2	1	7	1	6	2	3	1	1	2	3	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:33038791G>A	uc003zsd.1	+	9	1267	c.1084G>A	c.(1084-1086)GAA>AAA	p.E362K	DNAJA1_uc011lnt.1_Missense_Mutation_p.E205K	NM_001539	NP_001530	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	362					protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		GGACCAAGTAGAACTGGTGGA	0.468													9	46					0	0	0	0	A	33038791	A	A	33038791	3	1	261	1	0	0	0	0	1	0	0	0	4633	943	33	2	1114	2	DNAJA1	9	33038791	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	11629511	33038791	108174640	228	47604											
CCDC107	203260	broad.mit.edu	37	chr9	35660981	35660981	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttctgtttaaaggaggacGaggaggagattggtgacagt	12	10	15	4	1	1	2	0	1	1	1	1	7	1	5	0	5	0	1	0	5	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:35660981G>A	uc011lox.1	+	5	715	c.649G>A	c.(649-651)GAG>AAG	p.E217K	RMRP_uc003zxh.1_5'Flank|CCDC107_uc011loy.1_Missense_Mutation_p.E190K|CCDC107_uc003zxj.2_3'UTR|CCDC107_uc003zxk.2_3'UTR|C9orf100_uc003zxl.2_Intron|C9orf100_uc003zxm.1_3'UTR	NM_174923	NP_777583	Q8WV48	CC107_HUMAN	coiled-coil domain containing 107 precursor	217						integral to membrane					0	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AAAGGAGGACGAGGAGGAGAT	0.557													19	91					0	0	0	0	A	35660981	A	A	35660981	3	1	261	1	0	0	0	0	1	0	0	0	2754	1059	37	1	667	1	CCDC107	9	35660981	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2622190	35660981	105552450	229	47605											
POLR1E	64425	broad.mit.edu	37	chr9	37486584	37486584	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgggtcaggacccgagcttCcttgccatccccattctgac	6	11	9	15	1	2	1	1	1	1	0	4	3	4	2	5	2	2	1	5	2	0	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:37486584C>T	uc003zzz.1	+	1	435	c.147C>T	c.(145-147)TTC>TTT	p.F49F	POLR1E_uc011lqj.1_Intron|POLR1E_uc003zzy.1_Intron|POLR1E_uc011lqk.1_Intron	NM_022490	NP_071935	Q9GZS1	RPA49_HUMAN	RNA polymerase I associated factor 53	49					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		ACCCGAGCTTCCTTGCCATCC	0.527													9	11					0	0	0	0	T	37486584	T	T	37486584	2	4	261	1	0	0	0	0	0	0	0	1	12268	870	30	2		2	POLR1E	9	37486584	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1825603	37486584	103726847	230	47606											
FOXD4L5	653427	broad.mit.edu	37	chr9	70177786	70177786	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctctcggggaagcgcaacCccgccccaccgggccacctg	6	4	12	19	4	1	0	0	0	1	0	2	1	1	1	7	3	3	2	7	3	2	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:70177786C>G	uc010moc.2	-	1	1030	c.198G>C	c.(196-198)GGG>GGC	p.G66G		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	66					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						GAAGCGCAACCCCGCCCCACC	0.562													7	85					0	0	0	0	G	70177786	G	G	70177786	2	3	261	1	0	0	0	0	0	0	0	1	6036	610	22	4		4	FOXD4L5	9	70177786	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	32691202	70177786	71035645	231	47607											
C9orf71	169693	broad.mit.edu	37	chr9	71152191	71152191	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcctcagcactcttggcctCgcctctgggcgtcctctgag	3	11	11	16	2	4	1	1	1	3	0	6	1	5	1	4	2	2	1	4	2	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:71152191C>T	uc004agt.2	-	2	550	c.497G>A	c.(496-498)CGA>CAA	p.R166Q	uc004ags.1_RNA	NM_153237	NP_694969	Q8N6L7	CI071_HUMAN	hypothetical protein LOC169693	166						integral to membrane					0						CTCTTGGCCTCGCCTCTGGGC	0.562													4	41					0	0	0	0	T	71152191	T	T	71152191	3	4	261	1	0	0	0	0	1	0	0	0	2506	884	31	1	19	1	C9orf71	9	71152191	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	974405	71152191	70061240	232	47608											
TRPM6	140803	broad.mit.edu	37	chr9	77354741	77354741	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaaaacttgtcccggcttGagaatgtcatcctcagacca	12	10	8	11	1	2	3	2	2	0	2	4	4	4	3	3	1	1	1	3	1	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:77354741G>A	uc004ajl.1	-	34	5623	c.5385C>T	c.(5383-5385)CTC>CTT	p.L1795L	TRPM6_uc004ajk.1_Silent_p.L1790L|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Silent_p.L746L|TRPM6_uc010mpd.1_Silent_p.L628L|TRPM6_uc010mpe.1_Silent_p.L342L|TRPM6_uc004ajj.1_Silent_p.L751L	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1795	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTCCCGGCTTGAGAATGTCAT	0.507													53	71					0	0	0	0	A	77354741	A	A	77354741	2	1	261	1	0	0	0	0	0	0	0	1	16657	1277	45	2		2	TRPM6	9	77354741	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	6202550	77354741	63858690	233	47609											
COL15A1	1306	broad.mit.edu	37	chr9	101765755	101765755	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatttagcagcaacagcagcGgggctggccgaggtgcccat	10	6	14	11	2	0	0	0	0	0	0	0	1	0	0	2	4	6	4	2	4	3	2	rs142437738		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:101765755G>C	uc004azb.1	+	8	1292	c.1086G>C	c.(1084-1086)GCG>GCC	p.A362A		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	362	Nonhelical region 1 (NC1).|1.|4 X tandem repeats.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				CAACAGCAGCGGGGCTGGCCG	0.582													16	76					0	0	0	0	C	101765755	C	C	101765755	2	2	261	1	0	0	0	0	0	0	0	1	3687	1103	39	3		3	COL15A1	9	101765755	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	24411014	101765755	39447676	234	47610											
ERP44	23071	broad.mit.edu	37	chr9	102769866	102769866	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttaatctgtctacctttttCacttattaattgccgagcta	9	18	4	10	1	3	0	1	0	2	0	3	1	3	0	2	0	3	1	2	0	5	8			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:102769866C>T	uc004bam.2	-	9	1076	c.868G>A	c.(868-870)GAA>AAA	p.E290K	ERP44_uc010msy.2_RNA|ERP44_uc010msz.2_Missense_Mutation_p.E290K	NM_015051	NP_055866	Q9BS26	ERP44_HUMAN	thioredoxin domain containing 4 (endoplasmic	290					cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity				0						CTACCTTTTTCACTTATTAAT	0.338													12	42					0	0	0	0	T	102769866	T	T	102769866	3	4	261	1	0	0	0	0	1	0	0	0	5267	835	29	2	368	2	ERP44	9	102769866	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1004111	102769866	38443565	235	47611											
KIAA0368	23392	broad.mit.edu	37	chr9	114134893	114134893	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagcacaagaggtcttgtaGataggttctgaaaaggagaa	17	8	12	4	0	2	4	0	1	2	3	2	5	2	4	0	3	1	3	0	3	7	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:114134893G>A	uc004bfe.1	-	43	4878	c.4878C>T	c.(4876-4878)ATC>ATT	p.I1626I		NM_001080398	NP_001073867			KIAA0368 protein												0						AGGTCTTGTAGATAGGTTCTG	0.348													4	22					0	0	0	0	A	114134893	A	A	114134893	2	1	261	1	0	0	0	0	0	0	0	1	8210	932	33	2		2	KIAA0368	9	114134893	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	11365027	114134893	27078538	236	47612											
ZFP37	7539	broad.mit.edu	37	chr9	115805660	115805660	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagatgagttatacctaaaaGacttcccacattccttacat	14	12	5	10	0	0	3	0	1	0	2	2	4	2	3	3	0	2	1	3	0	5	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:115805660G>C	uc004bgm.1	-	4	1266	c.1238C>G	c.(1237-1239)TCT>TGT	p.S413C	ZFP37_uc011lwz.1_Missense_Mutation_p.S428C|ZFP37_uc011lxa.1_Missense_Mutation_p.S414C	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	413	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						ATACCTAAAAGACTTCCCACA	0.393													28	86					0	0	0	0	C	115805660	C	C	115805660	3	2	261	1	0	0	0	0	1	0	0	0	17715	942	33	2	658	2	ZFP37	9	115805660	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1670767	115805660	25407771	237	47613											
TRIM32	22954	broad.mit.edu	37	chr9	119460354	119460354	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggcgtctgccccggcaattCtgccggagctgtggtttggt	3	11	15	12	4	2	0	0	0	2	0	2	1	2	1	3	5	3	3	3	5	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:119460354C>T	uc004bjx.2	+	2	491	c.333C>T	c.(331-333)TTC>TTT	p.F111F	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Silent_p.F111F	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	111	B box-type.				fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						CCCGGCAATTCTGCCGGAGCT	0.592									Bardet-Biedl_syndrome				18	74					0	0	0	0	T	119460354	T	T	119460354	2	4	261	1	0	0	0	0	0	0	0	1	16573	912	32	2		2	TRIM32	9	119460354	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3654694	119460354	21753077	238	47614											
ASTN2	23245	broad.mit.edu	37	chr9	119976688	119976688	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggatgtcccagactgtccaGagtgtgggtcacctggctgc	6	10	14	11	0	1	2	1	0	0	2	3	3	3	3	3	3	1	1	3	3	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:119976688G>C	uc004bjs.1	-	3	1065	c.964C>G	c.(964-966)CTG>GTG	p.L322V	ASTN2_uc004bjr.1_Missense_Mutation_p.L322V|ASTN2_uc004bjt.1_Missense_Mutation_p.L322V	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	322	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						AGACTGTCCAGAGTGTGGGTC	0.552													16	114					0	0	0	0	C	119976688	C	C	119976688	3	2	261	1	0	0	0	0	1	0	0	0	1067	933	33	2	3214	2	ASTN2	9	119976688	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	516334	119976688	21236743	239	47615											
ANGPTL2	23452	broad.mit.edu	37	chr9	129851244	129851244	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaggtgttggggttcggtcGgatcatcatcaccactttct	7	13	12	9	2	4	0	3	0	1	0	6	2	4	1	1	5	0	2	1	5	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:129851244G>A	uc004bqr.1	-	5	1956	c.1456C>T	c.(1456-1458)CGA>TGA	p.R486*	RALGPS1_uc004bqo.1_Intron|RALGPS1_uc011mab.1_Intron|RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron|ANGPTL2_uc010mxg.1_Nonsense_Mutation_p.R184*	NM_012098	NP_036230	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2 precursor	486	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding				0						GGGTTCGGTCGGATCATCATC	0.607													23	111					0	0	0	0	A	129851244	A	A	129851244	4	1	261	1	0	0	0	0	0	1	0	0	614	1124	39	1	29	1	ANGPTL2	9	129851244	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	9874556	129851244	11362187	240	47616											
TTC16	158248	broad.mit.edu	37	chr9	130486622	130486622	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggacgagcagcaggagaaaGgactctacatcaaccgaggc	14	3	14	10	2	2	1	1	0	1	1	2	6	2	3	1	4	4	2	1	4	3	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:130486622G>A	uc004brq.1	+	8	1163	c.1096G>A	c.(1096-1098)GGA>AGA	p.G366R	PTRH1_uc011mah.1_Intron|TTC16_uc011mai.1_Missense_Mutation_p.G353R|TTC16_uc004brr.1_Missense_Mutation_p.G311R|TTC16_uc010mxn.1_5'UTR	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	366	TPR 7.						binding				0						GCAGGAGAAAGGACTCTACAT	0.662													6	23					0	0	0	0	A	130486622	A	A	130486622	3	1	261	1	0	0	0	0	1	0	0	0	16751	1001	35	4	1126	4	TTC16	9	130486622	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	635378	130486622	10726809	241	47617											
FPGS	2356	broad.mit.edu	37	chr9	130569916	130569916	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcatcgaccacaccagcctCctgggggatacggtggagaa	10	5	14	12	2	0	1	0	0	0	1	2	4	1	2	4	5	2	1	4	5	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:130569916C>T	uc004bsg.1	+	8	743	c.693C>T	c.(691-693)CTC>CTT	p.L231L	FPGS_uc004bsh.1_Silent_p.L48L|FPGS_uc011mal.1_Silent_p.L205L|FPGS_uc004bsi.1_Silent_p.L181L	NM_004957	NP_004948	Q05932	FOLC_HUMAN	folylpolyglutamate synthase isoform a precursor	231					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity				0					L-Glutamic Acid(DB00142)	ACACCAGCCTCCTGGGGGATA	0.488													4	25					0	0	0	0	T	130569916	T	T	130569916	2	4	261	1	0	0	0	0	0	0	0	1	6070	842	30	2		2	FPGS	9	130569916	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	83294	130569916	10643515	242	47618											
TRUB2	26995	broad.mit.edu	37	chr9	131084583	131084583	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttcgaggcactcacccttCagaagttgtagctccactgt	8	11	10	12	1	2	1	2	0	0	1	4	2	3	1	2	2	1	5	2	2	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:131084583C>G	uc004buq.1	-	1	115	c.105G>C	c.(103-105)CTG>CTC	p.L35L	COQ4_uc011max.1_5'Flank|COQ4_uc004bur.3_5'Flank|COQ4_uc004bus.2_5'Flank|COQ4_uc010mxy.2_5'Flank	NM_015679	NP_056494	O95900	TRUB2_HUMAN	TruB pseudouridine (psi) synthase homolog 2	35					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(1)	1						ACTCACCCTTCAGAAGTTGTA	0.562													7	62					0	0	0	0	G	131084583	G	G	131084583	2	3	261	1	0	0	0	0	0	0	0	1	16670	813	29	2		2	TRUB2	9	131084583	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	514667	131084583	10128848	243	47619											
TOR1B	27348	broad.mit.edu	37	chr9	132566591	132566591	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatcgactctgcacttccctCatgagcagaagataaaactg	13	10	7	11	1	2	3	1	1	1	2	4	4	3	3	1	0	3	2	1	0	4	3	rs78770065		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:132566591C>T	uc004byk.1	+	2	499	c.439C>T	c.(439-441)CAT>TAT	p.H147Y		NM_014506	NP_055321	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B) precursor	147					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding				0		Ovarian(14;0.0586)				GCACTTCCCTCATGAGCAGAA	0.483													26	82					0	0	0	0	T	132566591	T	T	132566591	3	4	261	1	0	0	0	0	1	0	0	0	16441	826	29	2	445	2	TOR1B	9	132566591	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1482008	132566591	8646840	244	47620											
OLFM1	10439	broad.mit.edu	37	chr9	137990304	137990304	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctacgatgaacttcagagcaGagtgtccaatcttgaagaaa	15	9	9	8	1	2	5	1	2	1	3	3	6	3	5	1	0	3	1	1	0	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:137990304G>C	uc010nar.2	+	4	945	c.629G>C	c.(628-630)AGA>ACA	p.R210T	OLFM1_uc004cfl.3_Missense_Mutation_p.R192T	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	210	Potential.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		CTTCAGAGCAGAGTGTCCAAT	0.527													15	56					0	0	0	0	C	137990304	C	C	137990304	3	2	261	1	0	0	0	0	1	0	0	0	10906	942	33	2	599	2	OLFM1	9	137990304	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5423713	137990304	3223127	245	47621											
NOTCH1	4851	broad.mit.edu	37	chr9	139402742	139402742	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acgtcgcagtaaaggccggtCcagccgctggggcactcgca	8	5	14	14	5	0	0	0	0	0	0	3	0	1	0	3	4	1	5	3	4	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:139402742C>T	uc004chz.2	-	20	3267	c.3267G>A	c.(3265-3267)TGG>TGA	p.W1089*	NOTCH1_uc004cia.1_Nonsense_Mutation_p.W319*	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1089	Extracellular (Potential).|EGF-like 28.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AAAGGCCGGTCCAGCCGCTGG	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			31	64					0	0	0	0	T	139402742	T	T	139402742	4	4	261	1	0	0	0	0	0	1	0	0	10601	856	30	2	4460	2	NOTCH1	9	139402742	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1412438	139402742	1810689	246	47622											
TMEM141	85014	broad.mit.edu	37	chr9	139686222	139686222	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaagggcgttttcaccttCgtcacaggtaggctgcgtcc	7	11	12	11	3	2	1	2	1	0	0	4	1	3	1	2	3	1	3	2	3	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:139686222C>T	uc004cje.3	+	2	160	c.114C>T	c.(112-114)TTC>TTT	p.F38F	TMEM141_uc011meg.1_Silent_p.F38F	NM_032928	NP_116317	Q96I45	TM141_HUMAN	transmembrane protein 141	38	Helical; (Potential).					integral to membrane					0	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.67e-06)|Epithelial(140;0.000112)		TTTTCACCTTCGTCACAGGTA	0.672											OREG0019622	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	49					0	0	0	0	T	139686222	T	T	139686222	2	4	261	1	0	0	0	0	0	0	0	1	16122	883	31	1		1	TMEM141	9	139686222	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	283480	139686222	1527209	247	47623											
MRPL41	64975	broad.mit.edu	37	chr9	140446891	140446891	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acctggaaaagtacggcttcGagcccacacaggagggaaag	14	4	13	10	2	0	0	0	0	0	0	1	4	0	3	2	4	2	2	2	4	4	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:140446891G>C	uc004cnh.3	+	2	488	c.358G>C	c.(358-360)GAG>CAG	p.E120Q	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	120					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		GTACGGCTTCGAGCCCACACA	0.602													11	23					0	0	0	0	C	140446891	C	C	140446891	3	2	261	1	0	0	0	0	1	0	0	0	9858	1059	37	3	360	3	MRPL41	9	140446891	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	760669	140446891	766540	248	47624											
EHMT1	79813	broad.mit.edu	37	chr9	140622883	140622883	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagatcaacaaaaacatttCtgactttggacgacagcagc	15	8	9	9	1	2	2	1	1	1	1	2	5	2	3	0	2	4	1	0	2	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:140622883C>G	uc011mfc.1	+	4	762	c.725C>G	c.(724-726)TCT>TGT	p.S242C	EHMT1_uc004coa.2_Missense_Mutation_p.S242C|EHMT1_uc004cob.1_Missense_Mutation_p.S211C	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	242					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		AAAAACATTTCTGACTTTGGA	0.458													11	85					0	0	0	0	G	140622883	G	G	140622883	3	3	261	1	0	0	0	0	1	0	0	0	5005	913	32	2	739	2	EHMT1	9	140622883	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	175992	140622883	590548	249	47625											
GTPBP4	23560	broad.mit.edu	37	chr10	1063059	1063059	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaagaatgctcagaagaaGatgaatcggttggggaagaa	17	7	14	3	1	1	7	1	2	0	5	2	8	1	8	0	3	1	2	0	3	7	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:1063059G>C	uc001ift.2	+	17	1868	c.1797G>C	c.(1795-1797)AAG>AAC	p.K599N	GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Missense_Mutation_p.K483N|GTPBP4_uc010qae.1_Missense_Mutation_p.K552N	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	599					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		CTCAGAAGAAGATGAATCGGT	0.403													15	63					0	0	0	0	C	1063059	C	C	1063059	3	2	261	1	0	0	0	0	1	0	0	0	6921	933	33	2	1863	2	GTPBP4	10	1063059	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08		1063059	134471688	250	47626											
WDR37	22884	broad.mit.edu	37	chr10	1123898	1123898	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacttctggaactgtttggtCaaatagaaagagaatttgaa	15	12	9	5	0	2	3	1	1	1	2	2	5	2	4	0	2	1	1	0	2	6	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:1123898C>G	uc001igf.1	+	3	363	c.190C>G	c.(190-192)CAA>GAA	p.Q64E	WDR37_uc001ige.2_Missense_Mutation_p.Q64E|WDR37_uc009xhm.1_Missense_Mutation_p.Q64E|WDR37_uc009xhn.1_Intron|WDR37_uc001igg.1_RNA	NM_014023	NP_054742	Q9Y2I8	WDR37_HUMAN	WD repeat domain 37	64											0		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)		ACTGTTTGGTCAAATAGAAAG	0.318													19	63					0	0	0	0	G	1123898	G	G	1123898	3	3	261	1	0	0	0	0	1	0	0	0	17359	827	29	2	196	2	WDR37	10	1123898	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	60839	1123898	134410849	251	47627											
DHTKD1	55526	broad.mit.edu	37	chr10	12126746	12126746	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcgaaactaatgctggaatCtcaggtaaaaaggagcatct	15	9	10	7	1	2	0	1	0	2	0	4	3	2	2	0	3	3	3	0	3	6	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:12126746C>G	uc001ild.3	+	3	617	c.518C>G	c.(517-519)TCT>TGT	p.S173C		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	173					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			ATGCTGGAATCTCAGGTAAAA	0.269													12	54					0	0	0	0	G	12126746	G	G	12126746	3	3	261	1	0	0	0	0	1	0	0	0	4522	913	32	2	528	2	DHTKD1	10	12126746	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	11002848	12126746	123408001	252	47628											
JMJD1C	221037	broad.mit.edu	37	chr10	64946111	64946111	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccttccataggctaatgttCattttcttatgcacaccaga	10	14	6	11	0	2	1	1	0	1	1	3	1	3	1	3	1	1	3	3	1	3	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:64946111C>T	uc001jmn.2	-	19	6903	c.6603G>A	c.(6601-6603)ATG>ATA	p.M2201I	JMJD1C_uc001jml.2_Missense_Mutation_p.M1964I|JMJD1C_uc001jmm.2_Missense_Mutation_p.M1913I|JMJD1C_uc010qiq.1_Missense_Mutation_p.M2019I|JMJD1C_uc009xpi.2_Missense_Mutation_p.M2019I|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmo.2_Missense_Mutation_p.M108I	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	2201					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GGCTAATGTTCATTTTCTTAT	0.318													8	32					0	0	0	0	T	64946111	T	T	64946111	3	4	261	1	0	0	0	0	1	0	0	0	7989	826	29	2	1051	2	JMJD1C	10	64946111	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	52819365	64946111	70588636	253	47629											
MYPN	84665	broad.mit.edu	37	chr10	69881415	69881415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgagccaagaagaattagacGaaagtgtcaatttggcaaga	17	8	11	5	1	1	5	1	1	0	4	1	6	1	5	1	1	1	1	1	1	7	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:69881415G>A	uc001jnm.3	+	3	405	c.220G>A	c.(220-222)GAA>AAA	p.E74K	MYPN_uc001jnl.1_Missense_Mutation_p.E74K|MYPN_uc001jnn.3_Intron|MYPN_uc001jno.3_Missense_Mutation_p.E74K|MYPN_uc001jnp.1_Missense_Mutation_p.E74K|MYPN_uc009xps.2_Missense_Mutation_p.E74K|MYPN_uc009xpt.2_Missense_Mutation_p.E74K|MYPN_uc010qit.1_5'UTR|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	74	Interaction with CARP.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						AGAATTAGACGAAAGTGTCAA	0.488													12	50					0	0	0	0	A	69881415	A	A	69881415	3	1	261	1	0	0	0	0	1	0	0	0	10151	1059	37	1	222	1	MYPN	10	69881415	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4935304	69881415	65653332	254	47630											
RUFY2	55680	broad.mit.edu	37	chr10	70156607	70156607	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttttgcatgagggctaatcGaagccacgctcttgctcgac	8	12	10	11	3	1	1	0	1	1	0	3	3	1	1	1	1	3	4	1	1	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:70156607G>A	uc001job.2	-	4	760	c.433C>T	c.(433-435)CGA>TGA	p.R145*	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Intron|RUFY2_uc010qiw.1_Nonsense_Mutation_p.R52*|RUFY2_uc001jod.1_Nonsense_Mutation_p.R110*|RUFY2_uc009xpv.1_5'UTR|RUFY2_uc001joe.1_Nonsense_Mutation_p.R110*	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	159	RUN.					nucleus	metal ion binding			ovary(1)	1						AGGGCTAATCGAAGCCACGCT	0.428													17	38					0	0	0	0	A	70156607	A	A	70156607	4	1	261	1	0	0	0	0	0	1	0	0	13804	1066	37	1	1665	1	RUFY2	10	70156607	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	275192	70156607	65378140	255	47631											
SUPV3L1	6832	broad.mit.edu	37	chr10	70958267	70958267	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtcggcagattgaaattcGgggattagaatcagctgtta	12	11	13	5	2	1	3	1	1	0	2	3	5	1	4	0	3	1	3	0	3	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:70958267G>A	uc001jpe.1	+	9	1218	c.1163G>A	c.(1162-1164)CGG>CAG	p.R388Q	SUPV3L1_uc010qjd.1_Missense_Mutation_p.R257Q	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	388	Helicase C-terminal.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						ATTGAAATTCGGGGATTAGAA	0.393													21	84					0	0	0	0	A	70958267	A	A	70958267	3	1	261	1	0	0	0	0	1	0	0	0	15468	1116	39	1	1197	1	SUPV3L1	10	70958267	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	801660	70958267	64576480	256	47632											
TTC18	118491	broad.mit.edu	37	chr10	75051064	75051064	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactagattctctcttccctCtttcctcagtgtcttctaca	7	17	3	14	0	6	1	1	0	5	1	9	1	8	1	2	0	2	0	2	0	3	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:75051064C>G	uc009xrc.2	-	20	2490	c.2369G>C	c.(2368-2370)AGA>ACA	p.R790T	TTC18_uc001jty.2_Missense_Mutation_p.R790T|TTC18_uc001jtv.3_Intron|TTC18_uc001jtw.3_Intron|TTC18_uc001jtx.2_Missense_Mutation_p.R171T	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	790							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					TCTCTTCCCTCTTTCCTCAGT	0.493													23	121					0	0	0	0	G	75051064	G	G	75051064	3	3	261	1	0	0	0	0	1	0	0	0	16753	913	32	2	1032	2	TTC18	10	75051064	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4092797	75051064	60483683	257	47633											
VCL	7414	broad.mit.edu	37	chr10	75877857	75877857	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgcgggaagctgaagctgCttcaatcaaaattcgaacag	13	9	11	8	2	2	1	2	1	0	0	3	3	2	2	0	1	5	3	0	1	6	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:75877857C>T	uc001jwd.2	+	22	3429	c.3335C>T	c.(3334-3336)GCT>GTT	p.A1112V	VCL_uc009xrr.2_Missense_Mutation_p.A793V|VCL_uc001jwe.2_Missense_Mutation_p.A1044V|VCL_uc010qkz.1_Missense_Mutation_p.A305V	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	1112	C-terminal tail.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					GCTGAAGCTGCTTCAATCAAA	0.517													4	69					0	0	0	0	T	75877857	T	T	75877857	3	4	261	1	0	0	0	0	1	0	0	0	17207	797	28	4	3421	4	VCL	10	75877857	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	826793	75877857	59656890	258	47634											
HECTD2	143279	broad.mit.edu	37	chr10	93242780	93242780	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgctcacttgctacgacaGatagctaccttagtggaagc	11	11	9	10	1	1	1	1	0	0	1	1	3	1	2	1	1	6	3	1	1	6	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:93242780G>C	uc001khl.2	+	8	868	c.768G>C	c.(766-768)CAG>CAC	p.Q256H	LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Missense_Mutation_p.Q256H|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_5'UTR|HECTD2_uc001khn.1_5'Flank	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	256					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						TGCTACGACAGATAGCTACCT	0.308													16	35					0	0	0	0	C	93242780	C	C	93242780	3	2	261	1	0	0	0	0	1	0	0	0	7079	933	33	2	822	2	HECTD2	10	93242780	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	17364923	93242780	42291967	259	47635											
CYP2C9	1559	broad.mit.edu	37	chr10	96702031	96702031	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggaattttgggatggggaaGaggagcattgaggaccgtgt	10	9	18	4	2	0	2	0	1	0	1	0	7	0	7	1	6	1	1	1	6	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:96702031G>C	uc001kka.3	+	3	439	c.414G>C	c.(412-414)AAG>AAC	p.K138N	CYP2C9_uc009xut.2_Missense_Mutation_p.K138N|CYP2C9_uc001kjz.2_Missense_Mutation_p.K138N	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	138					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GGATGGGGAAGAGGAGCATTG	0.502													16	68					0	0	0	0	C	96702031	C	C	96702031	3	2	261	1	0	0	0	0	1	0	0	0	4185	933	33	2	424	2	CYP2C9	10	96702031	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3459251	96702031	38832716	260	47636											
SFRP5	6425	broad.mit.edu	37	chr10	99527298	99527298	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctctgccgccccgtagaaGaaagggtagtagagggagca	11	5	16	9	2	1	3	0	0	1	3	1	4	1	4	3	3	2	5	3	3	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:99527298G>T	uc001kor.3	-	3	1093	c.927C>A	c.(925-927)TTC>TTA	p.F309L		NM_003015	NP_003006	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5 precursor	309					apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		CCCCGTAGAAGAAAGGGTAGT	0.587													5	21					0.00116845	0.00120024	1	0	T	99527298	T	T	99527298	3	4	261	1	0	0	0	0	1	0	0	0	14229	933	33	2	30	2	SFRP5	10	99527298	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2825267	99527298	36007449	261	47637											
SFRP5	6425	broad.mit.edu	37	chr10	99527328	99527328	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagagggagcaggggtaggaGaacatgaatttgactgcaaa	15	7	15	4	0	0	4	0	2	0	2	0	6	0	5	0	4	3	3	0	4	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:99527328G>A	uc001kor.3	-	3	1063	c.897C>T	c.(895-897)TTC>TTT	p.F299F		NM_003015	NP_003006	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5 precursor	299	NTR.				apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		AGGGGTAGGAGAACATGAATT	0.567													8	29					0	0	0	0	A	99527328	A	A	99527328	2	1	261	1	0	0	0	0	0	0	0	1	14229	933	33	2		2	SFRP5	10	99527328	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	30	99527328	36007419	262	47638											
CWF19L1	55280	broad.mit.edu	37	chr10	102003530	102003530	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccagcagggtcctggaggCtgagcttcatgtaaaagaaa	14	7	12	8	0	1	2	1	1	0	1	2	3	2	3	2	3	3	4	2	3	4	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:102003530C>A	uc001kqq.1	-	10	1056	c.969G>T	c.(967-969)CAG>CAT	p.Q323H	CWF19L1_uc001kqs.1_Missense_Mutation_p.Q75H|CWF19L1_uc001kqr.1_Missense_Mutation_p.Q323H|CWF19L1_uc001kqt.1_Splice_Site_p.P28_splice|CWF19L1_uc010qpn.1_Missense_Mutation_p.Q186H	NM_018294	NP_060764	Q69YN2	C19L1_HUMAN	CWF19-like 1, cell cycle control	323							catalytic activity				0		Colorectal(252;0.117)		Epithelial(162;3.78e-10)|all cancers(201;3.1e-08)		GTCCTGGAGGCTGAGCTTCAT	0.443													29	90					1.88708e-17	2.04265e-17	1	0	A	102003530	A	A	102003530	3	1	261	1	0	0	0	0	1	0	0	0	4088	796	28	4	667	4	CWF19L1	10	102003530	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2476202	102003530	33531217	263	47639											
PSD	5662	broad.mit.edu	37	chr10	104173810	104173810	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gccaaggcctccagcgaggcGaggctggtataggaggtgcc	8	5	17	11	2	0	0	0	0	0	0	1	3	1	1	4	6	2	2	4	6	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:104173810G>A	uc001kvg.1	-	5	1796	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L	PSD_uc001kvh.1_Silent_p.L44L|PSD_uc009xxd.1_Silent_p.L423L	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	423					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CCAGCGAGGCGAGGCTGGTAT	0.652													4	46					0	0	0	0	A	104173810	A	A	104173810	2	1	261	1	0	0	0	0	0	0	0	1	12708	1045	37	1		1	PSD	10	104173810	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2170280	104173810	31360937	264	47640											
MUC6	4588	broad.mit.edu	37	chr11	1016425	1016425	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaaatgaggaggacagctGattagttgtggaaacaggag	16	7	15	3	0	0	3	0	2	0	1	0	7	0	7	0	4	2	2	0	4	4	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:1016425G>A	uc001lsw.2	-	31	6427	c.6376C>T	c.(6376-6378)CAG>TAG	p.Q2126*		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	2126	Ser-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAGGACAGCTGATTAGTTGTG	0.527													5	26					0	0	0	0	A	1016425	A	A	1016425	4	1	261	1	0	0	0	0	0	1	0	0	10033	1299	45	2	955	2	MUC6	11	1016425	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08		1016425	133990091	265	47641											
RRP8	23378	broad.mit.edu	37	chr11	6622653	6622653	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctctgtcttctctgtgggggCctcagctggggcctggtctg	1	13	15	12	0	5	0	1	0	4	0	6	0	5	0	2	5	1	1	2	5	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:6622653C>T	uc001med.2	-	3	722	c.643G>A	c.(643-645)GCC>ACC	p.A215T	ILK_uc001mee.2_5'Flank|ILK_uc001mef.2_5'Flank|ILK_uc010rap.1_5'Flank|ILK_uc010raq.1_5'Flank|ILK_uc001meg.2_5'Flank|ILK_uc001meh.2_5'Flank	NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	215					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0						TCTGTGGGGGCCTCAGCTGGG	0.592													11	39					0	0	0	0	T	6622653	T	T	6622653	3	4	261	1	0	0	0	0	1	0	0	0	13755	739	26	4	747	4	RRP8	11	6622653	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5606228	6622653	128383863	266	47642											
DKK3	27122	broad.mit.edu	37	chr11	11988594	11988594	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtggccattttggtgcagtGaccccagacacacagctggt	8	9	13	11	0	0	2	0	1	0	1	0	2	0	2	3	4	2	2	3	4	0	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:11988594G>A	uc001mju.2	-	5	637	c.580C>T	c.(580-582)CAC>TAC	p.H194Y	DKK3_uc010rcf.1_Missense_Mutation_p.H166Y|DKK3_uc001mjv.2_Missense_Mutation_p.H194Y|DKK3_uc001mjw.2_Missense_Mutation_p.H194Y|DKK3_uc010rcg.1_Missense_Mutation_p.H194Y	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	194	DKK-type Cys-1.				adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		TTGGTGCAGTGACCCCAGACA	0.622											OREG0020766	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	41					0	0	0	0	A	11988594	A	A	11988594	3	1	261	1	0	0	0	0	1	0	0	0	4568	1290	45	2	484	2	DKK3	11	11988594	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5365941	11988594	123017922	267	47643											
C11orf58	10944	broad.mit.edu	37	chr11	16760339	16760339	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcaaggatgagtgctgccaGagagtctcacccgcatgggg	9	6	15	11	2	1	2	1	1	1	1	2	4	1	3	2	3	2	3	2	3	1	0	rs146011841		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:16760339G>C	uc001mmk.2	+	1	192	c.14G>C	c.(13-15)AGA>ACA	p.R5T	C11orf58_uc010rct.1_5'UTR|SOX6_uc001mmh.1_5'Flank	NM_014267	NP_055082	O00193	SMAP_HUMAN	small acidic protein isoform a	5											0						AGTGCTGCCAGAGAGTCTCAC	0.582													3	46					0	0	0	0	C	16760339	C	C	16760339	3	2	261	1	0	0	0	0	1	0	0	0	1657	942	33	2	16	2	C11orf58	11	16760339	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4771745	16760339	118246177	268	47644											
WT1	7490	broad.mit.edu	37	chr11	32417879	32417879	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcctgggtaagcacacatGaaggggcgtttctcactggt	9	9	13	10	1	1	1	1	1	1	0	2	1	1	1	1	4	2	3	1	4	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:32417879G>A	uc001mtn.1	-	7	1369	c.1173C>T	c.(1171-1173)TTC>TTT	p.F391F	WT1_uc001mtl.1_Silent_p.F179F|WT1_uc001mtm.1_Silent_p.F162F|WT1_uc001mto.1_Silent_p.F391F|WT1_uc001mtp.1_Silent_p.F374F|WT1_uc001mtq.1_Silent_p.F374F|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	323	C2H2-type 1.				adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.V380_S410del(1)	EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			AAGCACACATGAAGGGGCGTT	0.542			D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				17	49					0	0	0	0	A	32417879	A	A	32417879	2	1	261	1	0	0	0	0	0	0	0	1	17476	1281	45	2		2	WT1	11	32417879	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	15657540	32417879	102588637	269	47645											
C11orf41	25758	broad.mit.edu	37	chr11	33689480	33689480	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtacccccagagctctccctCcaggcttcctcgtcagtaca	7	9	7	18	1	2	1	1	0	1	1	6	1	4	1	5	1	3	4	5	1	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:33689480C>G	uc001mup.3	+	20	5472	c.5348C>G	c.(5347-5349)TCC>TGC	p.S1783C		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1777						integral to membrane				ovary(2)	2						AGCTCTCCCTCCAGGCTTCCT	0.687													7	12					0	0	0	0	G	33689480	G	G	33689480	3	3	261	1	0	0	0	0	1	0	0	0	1646	855	30	2	5426	2	C11orf41	11	33689480	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1271601	33689480	101317036	270	47646											
AHNAK	79026	broad.mit.edu	37	chr11	62286412	62286412	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctgcactttggggcctttCaggtcaccctctatttttgg	4	15	10	12	0	3	0	2	0	1	0	3	0	3	0	3	4	1	1	3	4	1	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62286412C>G	uc001ntl.2	-	5	15777	c.15477G>C	c.(15475-15477)CTG>CTC	p.L5159L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5159					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGGCCTTTCAGGTCACCCT	0.522													9	44					0	0	0	0	G	62286412	G	G	62286412	2	3	261	1	0	0	0	0	0	0	0	1	414	813	29	2		2	AHNAK	11	62286412	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	28596932	62286412	72720104	271	47647			2	72		8	8	12375	C		2.393183e-09
AHNAK	79026	broad.mit.edu	37	chr11	62291157	62291157	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactttagggcctttgatatCaacctctggccctttcagat	8	14	7	12	0	3	2	2	1	1	1	3	2	3	2	3	2	1	0	3	2	3	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62291157C>T	uc001ntl.2	-	5	11032	c.10732G>A	c.(10732-10734)GAT>AAT	p.D3578N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3578					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCTTTGATATCAACCTCTGGC	0.468													55	162					0	0	0	0	T	62291157	T	T	62291157	3	4	261	1	0	0	0	0	1	0	0	0	414	826	29	2	7060	2	AHNAK	11	62291157	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4745	62291157	72715359	272	47648			2	72		8	8	12375	C		2.393183e-09
AHNAK	79026	broad.mit.edu	37	chr11	62294428	62294428	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actttggggcccctgatgttCatatctggtacttcaagttt	7	16	9	9	0	3	1	2	1	1	0	3	1	3	1	2	3	1	3	2	3	3	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62294428C>G	uc001ntl.2	-	5	7761	c.7461G>C	c.(7459-7461)ATG>ATC	p.M2487I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2487					nervous system development	nucleus	protein binding	p.M2487V(1)		ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCCTGATGTTCATATCTGGTA	0.478													49	147					0	0	0	0	G	62294428	G	G	62294428	3	3	261	1	0	0	0	0	1	0	0	0	414	826	29	2	10331	2	AHNAK	11	62294428	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3271	62294428	72712088	273	47649			2	72		8	8	12375	C		2.393183e-09
AHNAK	79026	broad.mit.edu	37	chr11	62296791	62296791	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggtcgtgaacctccacatCtggggcatcaatgtccactt	8	11	10	12	1	2	1	1	1	1	0	5	1	4	1	3	3	1	1	3	3	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62296791C>G	uc001ntl.2	-	5	5398	c.5098G>C	c.(5098-5100)GAT>CAT	p.D1700H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1700					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACCTCCACATCTGGGGCATCA	0.493													60	241					0	0	0	0	G	62296791	G	G	62296791	3	3	261	1	0	0	0	0	1	0	0	0	414	913	32	2	12694	2	AHNAK	11	62296791	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2363	62296791	72709725	274	47650			2	72		8	8	12375	C		2.393183e-09
AHNAK	79026	broad.mit.edu	37	chr11	62296833	62296833	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggccctttaatgtcaacatCtggcactttcatttcacctt	8	15	6	12	0	4	0	3	0	1	0	4	0	4	0	2	2	1	1	2	2	2	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62296833C>G	uc001ntl.2	-	5	5356	c.5056G>C	c.(5056-5058)GAT>CAT	p.D1686H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1686					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATGTCAACATCTGGCACTTTC	0.488													71	259					0	0	0	0	G	62296833	G	G	62296833	3	3	261	1	0	0	0	0	1	0	0	0	414	913	32	2	12736	2	AHNAK	11	62296833	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	42	62296833	72709683	275	47651			2	72		8	8	12375	C		2.393183e-09
AHNAK	79026	broad.mit.edu	37	chr11	62297749	62297749	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attttcaccttgggcatcttCaggtgccaatctgggccatg	7	13	10	11	0	4	0	2	0	2	0	4	0	4	0	3	3	1	1	3	3	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62297749C>T	uc001ntl.2	-	5	4440	c.4140G>A	c.(4138-4140)CTG>CTA	p.L1380L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1380					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGCATCTTCAGGTGCCAAT	0.498													81	236					0	0	0	0	T	62297749	T	T	62297749	2	4	261	1	0	0	0	0	0	0	0	1	414	813	29	2		2	AHNAK	11	62297749	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	916	62297749	72708767	276	47652			2	72		8	8	12375	C		2.393183e-09
AHNAK	79026	broad.mit.edu	37	chr11	62298201	62298201	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattttgggtcctttgatttCaacatctggcactttcattt	7	19	6	9	0	3	1	2	1	1	0	4	1	4	1	1	2	1	1	1	2	1	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62298201C>G	uc001ntl.2	-	5	3988	c.3688G>C	c.(3688-3690)GAA>CAA	p.E1230Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1230					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCTTTGATTTCAACATCTGGC	0.483													89	285					0	0	0	0	G	62298201	G	G	62298201	3	3	261	1	0	0	0	0	1	0	0	0	414	835	29	2	14104	2	AHNAK	11	62298201	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	452	62298201	72708315	277	47653			2	72		8	8	12375	C		2.393183e-09
AHNAK	79026	broad.mit.edu	37	chr11	62298786	62298786	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagatctggagcattagtatCtacttttggtgcagaaatgt	11	14	10	6	0	2	2	0	0	2	2	2	3	2	3	0	2	3	3	0	2	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62298786C>G	uc001ntl.2	-	5	3403	c.3103G>C	c.(3103-3105)GAT>CAT	p.D1035H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1035					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GCATTAGTATCTACTTTTGGT	0.463													14	84					0	0	0	0	G	62298786	G	G	62298786	3	3	261	1	0	0	0	0	1	0	0	0	414	913	32	2	14689	2	AHNAK	11	62298786	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	585	62298786	72707730	278	47654			2	72		8	8	12375	C		2.393183e-09
SF1	7536	broad.mit.edu	37	chr11	64536578	64536578	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtaatgctgcgggtctctGagctctgccagggtcttaag	6	12	14	9	1	3	1	0	1	3	0	4	1	3	1	1	3	4	3	1	3	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:64536578G>C	uc001obb.1	-	8	1180	c.803C>G	c.(802-804)TCA>TGA	p.S268*	SF1_uc010rnm.1_5'UTR|SF1_uc010rnn.1_Nonsense_Mutation_p.S242*|SF1_uc001oaz.1_Nonsense_Mutation_p.S393*|SF1_uc001oba.1_Nonsense_Mutation_p.S268*|SF1_uc001obc.1_Nonsense_Mutation_p.S268*|SF1_uc001obd.1_Nonsense_Mutation_p.S268*|SF1_uc001obe.1_Nonsense_Mutation_p.S153*|SF1_uc010rno.1_Nonsense_Mutation_p.S153*	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	268					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						GCGGGTCTCTGAGCTCTGCCA	0.488													16	82					0	0	0	0	C	64536578	C	C	64536578	4	2	261	1	0	0	0	0	0	1	0	0	14210	1294	45	2	1278	2	SF1	11	64536578	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2237792	64536578	70469938	279	47655											
CFL1	1072	broad.mit.edu	37	chr11	65623593	65623593	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgatgttcttcttgtcctCactcaggcagaagagcaccg	9	11	10	11	1	4	3	2	1	2	2	5	4	5	3	2	1	1	3	2	1	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:65623593C>T	uc001ofs.2	-	2	358	c.124G>A	c.(124-126)GAG>AAG	p.E42K	CFL1_uc001oft.2_Missense_Mutation_p.E42K|CFL1_uc001ofu.2_3'UTR	NM_005507	NP_005498	P23528	COF1_HUMAN	cofilin 1 (non-muscle)	42	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding				0				READ - Rectum adenocarcinoma(159;0.169)		TTCTTGTCCTCACTCAGGCAG	0.547													17	56					0	0	0	0	T	65623593	T	T	65623593	3	4	261	1	0	0	0	0	1	0	0	0	3305	835	29	2	388	2	CFL1	11	65623593	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1087015	65623593	69382923	280	47656											
IGHMBP2	3508	broad.mit.edu	37	chr11	68704300	68704300	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggttcatcactgtgagcaaGagggccccgcgaccccgagc	9	5	13	14	3	2	2	2	1	0	1	2	4	2	2	4	2	2	2	4	2	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:68704300G>C	uc001ook.1	+	13	2454	c.2352G>C	c.(2350-2352)AAG>AAC	p.K784N	IGHMBP2_uc001ool.1_Missense_Mutation_p.K408N|IGHMBP2_uc001oom.1_Missense_Mutation_p.K362N	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	784	R3H.|SS DNA-binding (By similarity).				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTGTGAGCAAGAGGGCCCCGC	0.682													5	17					0	0	0	0	C	68704300	C	C	68704300	3	2	261	1	0	0	0	0	1	0	0	0	7630	933	33	2	2402	2	IGHMBP2	11	68704300	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3080707	68704300	66302216	281	47657											
FCHSD2	9873	broad.mit.edu	37	chr11	72600885	72600885	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacacttacccgttgttggtGaacaatgtttttatgctcac	9	16	7	9	1	1	1	1	1	0	0	1	1	1	1	1	1	4	4	1	1	5	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:72600885G>A	uc009ytl.2	-	11	1251	c.1030C>T	c.(1030-1032)CAC>TAC	p.H344Y	FCHSD2_uc010rrg.1_Missense_Mutation_p.H208Y|FCHSD2_uc001oth.3_Missense_Mutation_p.H288Y|FCHSD2_uc001oti.2_Missense_Mutation_p.H303Y	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	344							protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			CGTTGTTGGTGAACAATGTTT	0.393													7	12					0	0	0	0	A	72600885	A	A	72600885	3	1	261	1	0	0	0	0	1	0	0	0	5822	1290	45	2	1232	2	FCHSD2	11	72600885	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3896585	72600885	62405631	282	47658											
PLEKHB1	58473	broad.mit.edu	37	chr11	73372592	73372592	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggccatgggcatgcttgcggGagccgccactggggcggcgc	4	5	19	13	4	0	0	0	0	0	0	0	1	0	1	3	6	3	2	3	6	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:73372592G>C	uc001oua.2	+	8	1108	c.677G>C	c.(676-678)GGA>GCA	p.G226A	PLEKHB1_uc001oub.2_Missense_Mutation_p.G191A|PLEKHB1_uc001ouc.2_Missense_Mutation_p.G207A|PLEKHB1_uc001oud.2_Missense_Mutation_p.G172A|PLEKHB1_uc009ytq.2_Missense_Mutation_p.G172A	NM_021200	NP_067023	Q9UF11	PKHB1_HUMAN	pleckstrin homology domain containing, family B	226					multicellular organismal development|phototransduction	cytoplasm|integral to membrane	signal transducer activity			ovary(1)|lung(1)	2						ATGCTTGCGGGAGCCGCCACT	0.692											OREG0021217	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	62					0	0	0	0	C	73372592	C	C	73372592	3	2	261	1	0	0	0	0	1	0	0	0	12119	1174	41	2	707	2	PLEKHB1	11	73372592	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	771707	73372592	61633924	283	47659											
PGM2L1	283209	broad.mit.edu	37	chr11	74056565	74056565	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttcagaattttagaagaGactgtggtggctaacatata	13	12	10	6	0	1	3	1	0	0	3	1	4	1	3	1	2	1	1	1	2	6	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:74056565G>C	uc001ovb.1	-	9	1463	c.1167C>G	c.(1165-1167)GTC>GTG	p.V389V		NM_173582	NP_775853	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	389					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			ovary(1)	1	Breast(11;3.32e-06)					TTTTAGAAGAGACTGTGGTGG	0.333													10	52					0	0	0	0	C	74056565	C	C	74056565	2	2	261	1	0	0	0	0	0	0	0	1	11854	929	33	2		2	PGM2L1	11	74056565	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	683973	74056565	60949951	284	47660											
OR2AT4	341152	broad.mit.edu	37	chr11	74799889	74799889	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcgtgtaaatgagggggttGagaattggtgtgagaatggc	11	10	18	2	1	0	3	0	3	0	2	0	5	0	3	0	4	1	2	0	4	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:74799889G>C	uc010rro.1	-	1	870	c.870C>G	c.(868-870)CTC>CTG	p.L290L		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGAGGGGGTTGAGAATTGGTG	0.483													20	61					0	0	0	0	C	74799889	C	C	74799889	2	2	261	1	0	0	0	0	0	0	0	1	11041	1277	45	2		2	OR2AT4	11	74799889	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	743324	74799889	60206627	285	47661											
MRE11A	4361	broad.mit.edu	37	chr11	94179020	94179020	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgctgacacagcagtctttGagttcctgctacgggtagaa	10	11	11	9	1	1	3	0	2	1	1	2	3	2	3	1	1	4	5	1	1	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:94179020G>C	uc001peu.2	-	16	2012	c.1823C>G	c.(1822-1824)TCA>TGA	p.S608*	MRE11A_uc001pev.2_Intron|MRE11A_uc009ywj.2_Nonsense_Mutation_p.S611*	NM_005591	NP_005582	P49959	MRE11_HUMAN	meiotic recombination 11 homolog A isoform 1	608					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(4)|lung(1)	5		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				AGCAGTCTTTGAGTTCCTGCT	0.378								Homologous_recombination	Ataxia-Telangiectasia-Like_Disorder				32	89					0	0	0	0	C	94179020	C	C	94179020	4	2	261	1	0	0	0	0	0	1	0	0	9812	1294	45	2	323	2	MRE11A	11	94179020	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	19379131	94179020	40827496	286	47662											
BIRC3	330	broad.mit.edu	37	chr11	102195711	102195711	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcaagatttttctgccttGatgagaagttcctaccactg	11	14	7	9	0	2	3	1	2	1	2	3	4	3	3	3	0	2	1	3	0	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:102195711G>A	uc001pgx.2	+	3	693	c.471G>A	c.(469-471)TTG>TTA	p.L157L		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	baculoviral IAP repeat-containing protein 3	157					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|skin(1)	4	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TTTCTGCCTTGATGAGAAGTT	0.408			T	MALT1	MALT								49	150					0	0	0	0	A	102195711	A	A	102195711	2	1	261	1	0	0	0	0	0	0	0	1	1439	1281	45	2		2	BIRC3	11	102195711	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	8016691	102195711	32810805	287	47663											
EXPH5	23086	broad.mit.edu	37	chr11	108384448	108384448	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcctgttgacttaccaactCactagatttgacgtgatagc	10	13	8	10	1	1	4	1	3	0	1	2	4	2	4	2	0	3	1	2	0	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:108384448C>T	uc001pkk.2	-	6	1897	c.1786G>A	c.(1786-1788)GAG>AAG	p.E596K	EXPH5_uc010rvy.1_Missense_Mutation_p.E408K|EXPH5_uc010rvz.1_Missense_Mutation_p.E440K|EXPH5_uc010rwa.1_Missense_Mutation_p.E520K	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	596					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTTACCAACTCACTAGATTTG	0.418													6	85					0	0	0	0	T	108384448	T	T	108384448	3	4	261	1	0	0	0	0	1	0	0	0	5347	835	29	2	4187	2	EXPH5	11	108384448	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	6188737	108384448	26622068	288	47664											
FDX1	2230	broad.mit.edu	37	chr11	110306635	110306635	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaaggaaaagttggtgattCtctgctagatgttgtggttg	10	14	13	4	0	1	2	0	1	1	1	2	3	1	3	0	3	1	4	0	3	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:110306635C>T	uc001pkx.2	+	2	514	c.263C>T	c.(262-264)TCT>TTT	p.S88F		NM_004109	NP_004100	P10109	ADX_HUMAN	ferredoxin 1 precursor	88	2Fe-2S ferredoxin-type.				electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|iron ion binding				0		all_cancers(61;1.59e-12)|all_epithelial(67;8.38e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;5.27e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0384)|Colorectal(284;0.228)	Mitotane(DB00648)	GTTGGTGATTCTCTGCTAGAT	0.323													12	39					0	0	0	0	T	110306635	T	T	110306635	3	4	261	1	0	0	0	0	1	0	0	0	5836	913	32	2	269	2	FDX1	11	110306635	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1922187	110306635	24699881	289	47665											
DRD2	1813	broad.mit.edu	37	chr11	113281596	113281596	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcagtcacagtgtatgttCaggatgtgtgtgatgaagaa	11	13	13	4	0	2	3	2	2	0	1	2	4	2	4	0	1	1	3	0	1	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:113281596C>T	uc001pnz.2	-	7	1506	c.1185G>A	c.(1183-1185)CTG>CTA	p.L395L	DRD2_uc010rwv.1_Silent_p.L394L|DRD2_uc001poa.3_Silent_p.L395L|DRD2_uc001pob.3_Silent_p.L366L	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	395	Helical; Name=6; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	AGTGTATGTTCAGGATGTGTG	0.602													12	42					0	0	0	0	T	113281596	T	T	113281596	2	4	261	1	0	0	0	0	0	0	0	1	4779	813	29	2		2	DRD2	11	113281596	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2974961	113281596	21724920	290	47666											
MLL	4297	broad.mit.edu	37	chr11	118361969	118361969	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgactatgagagtaagatGatgcaatgtggaaagtgtga	15	10	14	2	0	0	5	0	4	0	2	0	8	0	6	0	1	1	2	0	1	4	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:118361969G>A	uc001pta.2	+	14	4778	c.4755G>A	c.(4753-4755)ATG>ATA	p.M1585I	MLL_uc001ptb.2_Missense_Mutation_p.M1585I|MLL_uc001pte.1_RNA	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1585	PHD-type 3.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AGAGTAAGATGATGCAATGTG	0.398			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								33	107					0	0	0	0	A	118361969	A	A	118361969	3	1	261	1	0	0	0	0	1	0	0	0	9673	1290	45	2	4809	2	MLL	11	118361969	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5080373	118361969	16644547	291	47667											
NTM	50863	broad.mit.edu	37	chr11	132082033	132082033	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttacttggagacacatctCtcccaaaggtaagagaacag	14	8	10	9	0	1	2	0	0	1	2	3	4	2	2	1	3	2	2	1	3	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:132082033C>G	uc001qgp.2	+	3	1182	c.518C>G	c.(517-519)TCT>TGT	p.S173C	NTM_uc001qgm.2_Missense_Mutation_p.S173C|NTM_uc010sch.1_Missense_Mutation_p.S164C|NTM_uc010sci.1_Missense_Mutation_p.S173C|NTM_uc010scj.1_Missense_Mutation_p.S132C|NTM_uc001qgo.2_Missense_Mutation_p.S173C|NTM_uc001qgq.2_Missense_Mutation_p.S173C|NTM_uc001qgr.2_5'UTR	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	173	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						AGACACATCTCTCCCAAAGGT	0.443													18	66					0	0	0	0	G	132082033	G	G	132082033	3	3	261	1	0	0	0	0	1	0	0	0	10753	913	32	2	614	2	NTM	11	132082033	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	13720064	132082033	2924483	292	47668											
NANOG	79923	broad.mit.edu	37	chr12	7942253	7942253	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccaaagcttgccttgctttGaagcatccgactgtaaagaa	12	10	8	11	1	0	2	0	1	0	1	1	3	1	2	3	0	4	4	3	0	5	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:7942253G>C	uc009zfy.1	+	1	259	c.43G>C	c.(43-45)GAA>CAA	p.E15Q		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	15					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		GCCTTGCTTTGAAGCATCCGA	0.438													9	105					0	0	0	0	C	7942253	C	C	7942253	3	2	261	1	0	0	0	0	1	0	0	0	10203	1291	45	2	45	2	NANOG	12	7942253	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08		7942253	125909642	293	47669											
TAS2R46	259292	broad.mit.edu	37	chr12	11214128	11214128	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	catgaagacaggtttgttttCcagactctcaaaactccaaa	14	11	6	10	0	1	3	1	1	1	2	4	3	3	3	2	1	1	2	2	1	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:11214128C>G	uc001qzp.1	-	1	766	c.766G>C	c.(766-768)GAA>CAA	p.E256Q	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176887	NP_795368	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	256	Extracellular (Potential).				sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		GGTTTGTTTTCCAGACTCTCA	0.423													18	126					0	0	0	0	G	11214128	G	G	11214128	3	3	261	1	0	0	0	0	1	0	0	0	15648	864	30	2	167	2	TAS2R46	12	11214128	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3271875	11214128	122637767	294	47670											
LRP6	4040	broad.mit.edu	37	chr12	12284896	12284896	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagttcatcactgtggtcttCacattcagtaaacccatcgc	10	12	7	12	1	5	0	4	0	1	0	6	1	5	0	1	1	1	2	1	1	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:12284896C>T	uc001rah.3	-	18	3971	c.3829G>A	c.(3829-3831)GAA>AAA	p.E1277K	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Intron	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1277	Extracellular (Potential).|LDL-receptor class A 1.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CTGTGGTCTTCACATTCAGTA	0.498													11	51					0	0	0	0	T	12284896	T	T	12284896	3	4	261	1	0	0	0	0	1	0	0	0	9012	835	29	2	1036	2	LRP6	12	12284896	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1070768	12284896	121566999	295	47671											
ABCC9	10060	broad.mit.edu	37	chr12	22015908	22015908	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctgtttgttaaaaggacttCcaaaagtaatattttcttct	12	18	5	6	0	3	0	0	0	3	0	4	1	4	1	1	1	0	3	1	1	6	8			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:22015908C>T	uc001rfi.1	-	18	2338	c.2318G>A	c.(2317-2319)GGA>GAA	p.G773E	ABCC9_uc001rfh.2_Missense_Mutation_p.G773E|ABCC9_uc001rfj.1_Missense_Mutation_p.G737E	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	773	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AAAAGGACTTCCAAAAGTAAT	0.343													5	27					0	0	0	0	T	22015908	T	T	22015908	3	4	261	1	0	0	0	0	1	0	0	0	59	855	30	2	2557	2	ABCC9	12	22015908	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	9731012	22015908	111835987	296	47672											
TSPAN11	441631	broad.mit.edu	37	chr12	31116785	31116785	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggagcagccgtcctggctGtgggcatctggaccctggtg	4	8	18	11	1	1	0	0	0	1	0	2	2	2	2	3	6	2	3	3	6	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:31116785G>A	uc010sju.1	+	3	489	c.109G>A	c.(109-111)GTG>ATG	p.V37M	TSPAN11_uc001rjp.2_Missense_Mutation_p.V37M|TSPAN11_uc010sjv.1_Missense_Mutation_p.V27M	NM_001080509	NP_001073978	A1L157	TSN11_HUMAN	tetraspanin 11	37	Helical; (Potential).					integral to membrane					0	all_lung(12;3.11e-10)|Lung NSC(12;5.24e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CGTCCTGGCTGTGGGCATCTG	0.577													20	52					0	0	0	0	A	31116785	A	A	31116785	3	1	261	1	0	0	0	0	1	0	0	0	16702	1377	48	4	115	4	TSPAN11	12	31116785	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	9100877	31116785	102735110	297	47673											
ABCD2	225	broad.mit.edu	37	chr12	39947792	39947792	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacatagttcattgagtctCtgctgcattttgggaattcc	8	17	8	8	0	2	1	1	1	1	0	4	2	3	2	1	1	3	3	1	1	3	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:39947792C>G	uc001rmb.2	-	10	2571	c.2145G>C	c.(2143-2145)CAG>CAC	p.Q715H		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	715					fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						CATTGAGTCTCTGCTGCATTT	0.343													6	37					0	0	0	0	G	39947792	G	G	39947792	3	3	261	1	0	0	0	0	1	0	0	0	61	912	32	2	81	2	ABCD2	12	39947792	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	8831007	39947792	93904103	298	47674											
ADCY6	112	broad.mit.edu	37	chr12	49171950	49171950	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgtaaccgcgggtctcctGaaaggcctggcgctgagaca	9	7	14	11	3	1	2	0	2	1	1	2	4	1	2	3	3	1	2	3	3	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:49171950G>C	uc001rsh.3	-	2	1615	c.955C>G	c.(955-957)CAG>GAG	p.Q319E	ADCY6_uc001rsj.3_Missense_Mutation_p.Q319E|ADCY6_uc001rsi.3_Missense_Mutation_p.Q319E	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	319	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CGGGTCTCCTGAAAGGCCTGG	0.632													5	18					0	0	0	0	C	49171950	C	C	49171950	3	2	261	1	0	0	0	0	1	0	0	0	298	1299	45	2	2631	2	ADCY6	12	49171950	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	9224158	49171950	84679945	299	47675											
PRPF40B	25766	broad.mit.edu	37	chr12	50027427	50027427	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcccatcacagttctagtCaaacaagaggctgcagggtg	11	10	10	10	0	3	1	2	0	1	1	4	1	4	1	1	2	2	3	1	2	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:50027427C>G	uc001rur.1	+	8	586	c.522C>G	c.(520-522)GTC>GTG	p.V174V	PRPF40B_uc001rup.1_Silent_p.V196V|PRPF40B_uc001ruq.1_Silent_p.V168V|PRPF40B_uc001rus.1_Silent_p.V117V	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	174					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CAGTTCTAGTCAAACAAGAGG	0.537													4	46					0	0	0	0	G	50027427	G	G	50027427	2	3	261	1	0	0	0	0	0	0	0	1	12634	813	29	2		2	PRPF40B	12	50027427	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	855477	50027427	83824468	300	47676											
KRT74	121391	broad.mit.edu	37	chr12	52967185	52967185	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctcagggtccagctccacgTtgaggggggccaagaggctc	7	7	15	12	1	1	2	1	1	1	1	5	2	3	2	3	5	1	3	3	5	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:52967185T>C	uc001sap.1	-	1	425	c.377A>G	c.(376-378)AAC>AGC	p.N126S		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	126	Head.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		CAGCTCCACGTTGAGGGGGGC	0.597													26	65					0	0	0	0	C	52967185	C	C	52967185	3	2	261	1	0	0	0	0	1	0	0	0	8526	1725	60	5	1248	5	KRT74	12	52967185	Missense_Mutation	SNP	T	TCGA-CV-7427-01A-11D-2078-08	2939758	52967185	80884710	301	47677											
ESYT1	23344	broad.mit.edu	37	chr12	56531676	56531676	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aagtctttgacaaggacttgGacaaggatgattttctgggc	11	12	12	6	0	2	2	0	2	2	0	2	5	2	5	0	4	0	0	0	4	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:56531676G>C	uc001sjq.2	+	19	2226	c.2176G>C	c.(2176-2178)GAC>CAC	p.D726H	ESYT1_uc001sjr.2_Missense_Mutation_p.D736H	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	726	C2 3.					integral to membrane				ovary(4)|skin(1)	5						CAAGGACTTGGACAAGGATGA	0.488													18	53					0	0	0	0	C	56531676	C	C	56531676	3	2	261	1	0	0	0	0	1	0	0	0	5288	1174	41	2	2280	2	ESYT1	12	56531676	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3564491	56531676	77320219	302	47678											
SLC26A10	65012	broad.mit.edu	37	chr12	58018660	58018660	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acctcttagctcctccaggtCccggggctctgcatcctgag	5	10	10	16	1	2	1	0	1	2	0	6	1	6	1	5	3	2	3	5	3	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:58018660C>T	uc001spe.2	+	10	1550	c.1239C>T	c.(1237-1239)GTC>GTT	p.V413V	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_RNA	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	413	STAS.					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					TCCTCCAGGTCCCGGGGCTCT	0.587													19	69					0	0	0	0	T	58018660	T	T	58018660	2	4	261	1	0	0	0	0	0	0	0	1	14579	842	30	2		2	SLC26A10	12	58018660	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1486984	58018660	75833235	303	47679											
MSRB3	253827	broad.mit.edu	37	chr12	65722331	65722331	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgaaggagaatacacacatCacaaagatcctggaatatat	18	9	7	7	0	1	3	1	1	0	2	2	5	2	4	1	2	1	0	1	2	7	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:65722331C>T	uc001ssn.2	+	3	293	c.232C>T	c.(232-234)CAC>TAC	p.H78Y	MSRB3_uc001ssm.2_Missense_Mutation_p.H71Y|MSRB3_uc009zqp.2_Missense_Mutation_p.H71Y	NM_198080	NP_932346	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3 isoform 1	78					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		ATACACACATCACAAAGATCC	0.299													9	46					0	0	0	0	T	65722331	T	T	65722331	3	4	261	1	0	0	0	0	1	0	0	0	9942	826	29	2	322	2	MSRB3	12	65722331	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7703671	65722331	68129564	304	47680											
CAND1	55832	broad.mit.edu	37	chr12	67699870	67699870	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatgtgtagctgcccttactCgagcatgccctaaagaggga	11	9	11	10	1	0	1	0	0	0	1	1	3	0	2	2	1	5	3	2	1	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:67699870C>T	uc001stn.2	+	10	2859	c.2422C>T	c.(2422-2424)CGA>TGA	p.R808*	CAND1_uc001sto.2_Nonsense_Mutation_p.R318*	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	808	HEAT 18.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TGCCCTTACTCGAGCATGCCC	0.443													31	50					0	0	0	0	T	67699870	T	T	67699870	4	4	261	1	0	0	0	0	0	1	0	0	2627	876	31	1	2460	1	CAND1	12	67699870	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1977539	67699870	66152025	305	47681											
PTPRB	5787	broad.mit.edu	37	chr12	70983837	70983837	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccggtacgagccccgtgtCatccatgacatactgtgttt	7	12	9	13	3	1	1	1	1	0	0	3	2	3	1	4	1	3	2	4	1	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:70983837C>T	uc001swb.3	-	6	1333	c.1303G>A	c.(1303-1305)GAC>AAC	p.D435N	PTPRB_uc010sto.1_Missense_Mutation_p.D435N|PTPRB_uc010stp.1_Intron|PTPRB_uc001swc.3_Missense_Mutation_p.D653N|PTPRB_uc001swa.3_Missense_Mutation_p.D653N|PTPRB_uc001swd.3_Missense_Mutation_p.D652N|PTPRB_uc009zrr.1_Missense_Mutation_p.D532N	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	435	Fibronectin type-III 5.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGCCCCGTGTCATCCATGACA	0.493											OREG0021990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	102					0	0	0	0	T	70983837	T	T	70983837	3	4	261	1	0	0	0	0	1	0	0	0	12861	826	29	2	4798	2	PTPRB	12	70983837	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3283967	70983837	62868058	306	47682											
KCNC2	3747	broad.mit.edu	37	chr12	75444683	75444683	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtatgtccaagcaccctcaGacctacaaaatggcgggtga	13	7	10	11	1	1	2	1	1	0	1	2	2	2	2	3	2	2	2	3	2	5	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:75444683G>A	uc001sxg.1	-	3	1646	c.1102C>T	c.(1102-1104)CTG>TTG	p.L368L	KCNC2_uc009zry.2_Silent_p.L368L|KCNC2_uc001sxe.2_Silent_p.L368L|KCNC2_uc001sxf.2_Silent_p.L368L|KCNC2_uc010stw.1_Silent_p.L368L	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	368	Helical; Voltage-sensor; Name=Segment S4; (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						AGCACCCTCAGACCTACAAAA	0.438													19	25					0	0	0	0	A	75444683	A	A	75444683	2	1	261	1	0	0	0	0	0	0	0	1	8054	933	33	2		2	KCNC2	12	75444683	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4460846	75444683	58407212	307	47683											
ACSS3	79611	broad.mit.edu	37	chr12	81613830	81613830	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgcaaaaactgaaggctCggtgtttaggaaatattgtg	14	11	11	5	1	0	1	0	1	0	0	1	2	0	2	0	3	2	3	0	3	6	4	rs142377880		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:81613830C>A	uc001szl.1	+	11	1580	c.1489C>A	c.(1489-1491)CGG>AGG	p.R497R	ACSS3_uc001szm.1_Silent_p.R496R|ACSS3_uc001szn.1_Silent_p.R179R	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	497						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						ACTGAAGGCTCGGTGTTTAGG	0.269													7	48					4.68919e-08	4.9689e-08	1	0	A	81613830	A	A	81613830	2	1	261	1	0	0	0	0	0	0	0	1	190	875	31	3		3	ACSS3	12	81613830	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	6169147	81613830	52238065	308	47684											
FGD6	55785	broad.mit.edu	37	chr12	95478362	95478362	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactttagactcggaattctCatctttaacttgaataacag	13	15	5	8	1	2	2	1	1	2	1	4	3	2	3	0	1	3	0	0	1	6	8			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:95478362C>G	uc001tdp.3	-	20	4392	c.4168G>C	c.(4168-4170)GAG>CAG	p.E1390Q	FGD6_uc009zsx.2_Missense_Mutation_p.E523Q	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1390	PH 2.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding	p.E1390D(1)		ovary(2)|breast(1)	3						TCGGAATTCTCATCTTTAACT	0.343													25	39					0	0	0	0	G	95478362	G	G	95478362	3	3	261	1	0	0	0	0	1	0	0	0	5869	835	29	2	132	2	FGD6	12	95478362	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	13864532	95478362	38373533	309	47685											
ACACB	32	broad.mit.edu	37	chr12	109613984	109613984	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaagaattggttttccattGatgatcaaagcttctgaagg	13	13	10	5	0	2	4	1	3	1	1	3	5	3	4	1	2	1	2	1	2	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:109613984G>C	uc001tob.2	+	9	1472	c.1353G>C	c.(1351-1353)TTG>TTC	p.L451F	ACACB_uc001toc.2_Missense_Mutation_p.L451F	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	451	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GTTTTCCATTGATGATCAAAG	0.512													119	164					0	0	0	0	C	109613984	C	C	109613984	3	2	261	1	0	0	0	0	1	0	0	0	107	1281	45	2	1383	2	ACACB	12	109613984	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	14135622	109613984	24237911	310	47686											
IFT81	28981	broad.mit.edu	37	chr12	110628776	110628776	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatagttacacccaagaaGagctagaaagagtatctgca	17	8	9	7	0	1	4	0	0	1	4	1	5	1	4	1	0	3	4	1	0	8	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:110628776G>C	uc001tqi.2	+	13	1520	c.1390G>C	c.(1390-1392)GAG>CAG	p.E464Q	IFT81_uc001tqh.2_Missense_Mutation_p.E464Q|IFT81_uc001tqj.2_RNA	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	464					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						CACCCAAGAAGAGCTAGAAAG	0.338													20	48					0	0	0	0	C	110628776	C	C	110628776	3	2	261	1	0	0	0	0	1	0	0	0	7604	943	33	2	1548	2	IFT81	12	110628776	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1014792	110628776	23223119	311	47687											
IFT81	28981	broad.mit.edu	37	chr12	110628806	110628806	+	Frame_Shift_Del	DEL	G	-	-																															gagtatctgcactgaagagtGaagttgatgaaatgaaagga																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:110628806delG	uc001tqi.2	+	13	1550	c.1420delG	c.(1420-1422)GAAfs	p.E474fs	IFT81_uc001tqh.2_Frame_Shift_Del_p.E474fs|IFT81_uc001tqj.2_RNA	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	474					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						ACTGAAGAGTGAAGTTGATGA	0.333													---	---	---								-	110628806	-	-	110628806	7	5	261	1	0	1	0	1	0	0	0	0	7604	1291	45	0	1578	0	IFT81	12	110628806	Frame_Shift_Del	DEL	G	TCGA-CV-7427-01A-11D-2078-08	30	110628806	23223089	312	47688											
FBXO21	23014	broad.mit.edu	37	chr12	117603392	117603392	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagagatccagcgagtctctCaggagctggtatgactggtc	9	10	13	9	1	2	2	1	1	1	1	5	5	3	3	1	3	2	2	1	3	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:117603392C>T	uc001twk.2	-	9	1263	c.1224G>A	c.(1222-1224)CTG>CTA	p.L408L	FBXO21_uc001twj.2_Silent_p.L408L|FBXO21_uc009zwq.2_Silent_p.L348L|FBXO21_uc001twl.1_Silent_p.L21L	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	408					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		GCGAGTCTCTCAGGAGCTGGT	0.507													7	59					0	0	0	0	T	117603392	T	T	117603392	2	4	261	1	0	0	0	0	0	0	0	1	5765	813	29	2		2	FBXO21	12	117603392	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	6974586	117603392	16248503	313	47689											
P2RX4	5025	broad.mit.edu	37	chr12	121670829	121670829	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgtgacatcatagtcctCtactgcatgaagaaaagact	13	11	8	9	0	2	4	1	2	1	2	3	4	3	4	1	0	2	1	1	0	5	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:121670829C>T	uc001tzr.2	+	11	1378	c.1074C>T	c.(1072-1074)CTC>CTT	p.L358L	P2RX4_uc009zxc.2_Silent_p.L331L|P2RX4_uc001tzs.2_Silent_p.L374L|P2RX4_uc009zxb.2_RNA|P2RX4_uc010szt.1_Silent_p.L257L	NM_002560	NP_002551	Q99571	P2RX4_HUMAN	purinergic receptor P2X4	358	Helical; Name=2; (Potential).				endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCATAGTCCTCTACTGCATGA	0.507													21	232					0	0	0	0	T	121670829	T	T	121670829	2	4	261	1	0	0	0	0	0	0	0	1	11396	900	32	2		2	P2RX4	12	121670829	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4067437	121670829	12181066	314	47690											
P2RX4	5025	broad.mit.edu	37	chr12	121670850	121670850	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactgcatgaagaaaagactCtactatcgggagaagaaata	18	8	9	6	1	1	5	0	1	1	4	2	6	1	5	0	1	3	1	0	1	9	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:121670850C>G	uc001tzr.2	+	11	1399	c.1095C>G	c.(1093-1095)CTC>CTG	p.L365L	P2RX4_uc009zxc.2_Silent_p.L338L|P2RX4_uc001tzs.2_Silent_p.L381L|P2RX4_uc009zxb.2_RNA|P2RX4_uc010szt.1_Silent_p.L264L	NM_002560	NP_002551	Q99571	P2RX4_HUMAN	purinergic receptor P2X4	365	Cytoplasmic (Potential).				endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGAAAAGACTCTACTATCGGG	0.512													18	202					0	0	0	0	G	121670850	G	G	121670850	2	3	261	1	0	0	0	0	0	0	0	1	11396	900	32	2		2	P2RX4	12	121670850	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	21	121670850	12181045	315	47691											
UBC	7316	broad.mit.edu	37	chr12	125398224	125398224	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggagggatgccttccttatCttggatctttgccttgacat	7	15	10	9	0	2	1	0	1	2	0	3	4	3	4	3	3	2	0	3	3	1	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:125398224C>G	uc001ugs.3	-	2	542	c.94G>C	c.(94-96)GAT>CAT	p.D32H	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.D32H|UBC_uc001ugt.2_Missense_Mutation_p.D32H|UBC_uc001ugv.2_Missense_Mutation_p.D32H|UBC_uc001ugw.2_5'UTR|UBC_uc009zyf.1_RNA	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	32	Ubiquitin-like 1.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CCTTCCTTATCTTGGATCTTT	0.502													13	175					0	0	0	0	G	125398224	G	G	125398224	3	3	261	1	0	0	0	0	1	0	0	0	16910	913	32	2	1967	2	UBC	12	125398224	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3727374	125398224	8453671	316	47692											
TMEM132D	121256	broad.mit.edu	37	chr12	129569056	129569056	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acccacctcctgctggagacGatgggcactctccaaccctt	8	8	8	17	1	1	1	0	0	1	1	3	3	2	1	5	2	2	2	5	2	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:129569056G>C	uc009zyl.1	-	6	1963	c.1635C>G	c.(1633-1635)ATC>ATG	p.I545M	TMEM132D_uc001uia.2_Missense_Mutation_p.I83M	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	545	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TGCTGGAGACGATGGGCACTC	0.517													5	11					0	0	0	0	C	129569056	C	C	129569056	3	2	261	1	0	0	0	0	1	0	0	0	16113	1048	37	3	1680	3	TMEM132D	12	129569056	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4170832	129569056	4282839	317	47693											
GJA3	2700	broad.mit.edu	37	chr13	20716822	20716822	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccagcatgaagatgatgaaGatggtcttctccgtgggcct	9	10	13	9	1	2	5	0	3	2	2	3	5	2	5	3	2	1	1	3	2	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:20716822G>C	uc001umx.1	-	2	778	c.606C>G	c.(604-606)ATC>ATG	p.I202M		NM_021954	NP_068773	Q9Y6H8	CXA3_HUMAN	connexin 46	202	Helical; (Potential).				cell-cell signaling|visual perception	connexon complex|integral to membrane				pancreas(1)	1		all_cancers(29;1.4e-21)|all_epithelial(30;8.75e-19)|all_lung(29;1.28e-17)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000554)|Epithelial(112;0.000872)|OV - Ovarian serous cystadenocarcinoma(117;0.0105)|Lung(94;0.0251)|LUSC - Lung squamous cell carcinoma(192;0.0784)		AGATGATGAAGATGGTCTTCT	0.612													13	36					0	0	0	0	C	20716822	C	C	20716822	3	2	261	1	0	0	0	0	1	0	0	0	6439	932	33	2	705	2	GJA3	13	20716822	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08		20716822	94453056	318	47694											
SACS	26278	broad.mit.edu	37	chr13	23912713	23912713	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatccttctgaacacatggtGaaattcttccactgtgatct	11	14	6	10	0	3	3	0	3	3	0	5	3	5	3	2	1	1	0	2	1	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:23912713G>C	uc001uon.2	-	10	5891	c.5302C>G	c.(5302-5304)CAC>GAC	p.H1768D	SACS_uc001uoo.2_Missense_Mutation_p.H1621D|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1768					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AACACATGGTGAAATTCTTCC	0.443													22	140					0	0	0	0	C	23912713	C	C	23912713	3	2	261	1	0	0	0	0	1	0	0	0	13869	1290	45	2	8441	2	SACS	13	23912713	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3195891	23912713	91257165	319	47695											
PARP4	143	broad.mit.edu	37	chr13	25026704	25026704	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggagtgttttccagaagtCtgtgttccccatggtaggtg	6	14	13	8	1	1	1	0	0	1	1	4	2	3	2	3	3	0	3	3	3	2	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:25026704C>T	uc001upl.2	-	24	2960	c.2854G>A	c.(2854-2856)GAC>AAC	p.D952N	PARP4_uc010tdc.1_Missense_Mutation_p.D952N	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	952	VWFA.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TTCCAGAAGTCTGTGTTCCCC	0.488													20	62					0	0	0	0	T	25026704	T	T	25026704	3	4	261	1	0	0	0	0	1	0	0	0	11517	913	32	2	2364	2	PARP4	13	25026704	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1113991	25026704	90143174	320	47696											
ATP8A2	51761	broad.mit.edu	37	chr13	26125501	26125501	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccaaagcgcctctcaagaGatcaaatgttgagaaggtga	16	7	10	8	1	2	3	2	2	1	2	3	5	2	3	2	1	2	1	2	1	5	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:26125501G>C	uc001uqk.2	+	11	1059	c.917G>C	c.(916-918)AGA>ACA	p.R306T	ATP8A2_uc010tdi.1_Missense_Mutation_p.R266T|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.R266T	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	266	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CCTCTCAAGAGATCAAATGTT	0.507													9	33					0	0	0	0	C	26125501	C	C	26125501	3	2	261	1	0	0	0	0	1	0	0	0	1195	942	33	2	959	2	ATP8A2	13	26125501	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1098797	26125501	89044377	321	47697											
MTIF3	219402	broad.mit.edu	37	chr13	28009980	28009980	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagcttgtggcctagatgaGaatgtagctattccaggcat	11	11	11	8	0	0	2	0	1	0	2	1	3	1	2	2	2	2	4	2	2	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:28009980G>C	uc001urh.2	-	3	1893	c.669C>G	c.(667-669)TTC>TTG	p.F223L	MTIF3_uc001uri.2_Missense_Mutation_p.F223L|MTIF3_uc001urj.2_Missense_Mutation_p.F223L|MTIF3_uc001urk.2_Missense_Mutation_p.F223L	NM_152912	NP_690876	Q9H2K0	IF3M_HUMAN	mitochondrial translational initiation factor 3	223					regulation of translational initiation|ribosome disassembly	mitochondrion	ribosomal small subunit binding|translation initiation factor activity			ovary(1)|skin(1)	2		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.108)|OV - Ovarian serous cystadenocarcinoma(117;0.157)		GCCTAGATGAGAATGTAGCTA	0.383													19	61					0	0	0	0	C	28009980	C	C	28009980	3	2	261	1	0	0	0	0	1	0	0	0	9988	933	33	2	171	2	MTIF3	13	28009980	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1884479	28009980	87159898	322	47698											
C13orf33	84935	broad.mit.edu	37	chr13	31495235	31495235	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatggacatggtcatctcctCagtgattggagaaagttacc	11	11	11	8	0	3	2	2	1	1	1	4	5	3	3	2	3	1	1	2	3	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:31495235C>T	uc001uth.3	+	3	814	c.473C>T	c.(472-474)TCA>TTA	p.S158L	uc001utg.1_Intron	NM_032849	NP_116238	Q5VYS4	CM033_HUMAN	hypothetical protein LOC84935	158											0		Lung SC(185;0.0281)		all cancers(112;0.00914)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.0559)|GBM - Glioblastoma multiforme(144;0.244)		GTCATCTCCTCAGTGATTGGA	0.483													4	22					0	0	0	0	T	31495235	T	T	31495235	3	4	261	1	0	0	0	0	1	0	0	0	1733	838	29	2	483	2	C13orf33	13	31495235	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3485255	31495235	83674643	323	47699											
NBEA	26960	broad.mit.edu	37	chr13	35751193	35751193	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggatccggatagacttcttCaggatgttgatatcaatcgc	11	12	10	8	2	3	2	2	1	1	1	5	5	4	5	1	3	0	1	1	3	3	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:35751193C>T	uc001uvb.2	+	28	4821	c.4615C>T	c.(4615-4617)CAG>TAG	p.Q1539*	NBEA_uc010abi.2_Nonsense_Mutation_p.Q227*	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1539						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TAGACTTCTTCAGGATGTTGA	0.363													3	8					0	0	0	0	T	35751193	T	T	35751193	4	4	261	1	0	0	0	0	0	1	0	0	10240	827	29	2	4725	2	NBEA	13	35751193	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	4255958	35751193	79418685	324	47700											
AKAP11	11215	broad.mit.edu	37	chr13	42876840	42876840	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaagtggatccgtttattCtttcattaccaccaagttct	10	15	7	9	1	3	1	1	0	2	1	4	3	4	2	3	1	1	2	3	1	4	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:42876840C>G	uc001uys.1	+	8	4133	c.3958C>G	c.(3958-3960)CTT>GTT	p.L1320V		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1320					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TCCGTTTATTCTTTCATTACC	0.398													5	45					0	0	0	0	G	42876840	G	G	42876840	3	3	261	1	0	0	0	0	1	0	0	0	447	913	32	2	3980	2	AKAP11	13	42876840	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7125647	42876840	72293038	325	47701											
LCP1	3936	broad.mit.edu	37	chr13	46733075	46733075	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaggcaagcaagcagccttGaacaagtcattcaactcatt	16	8	7	10	0	3	1	3	1	0	0	3	1	3	1	1	1	5	3	1	1	6	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:46733075G>C	uc001vaz.3	-	3	240	c.114C>G	c.(112-114)TTC>TTG	p.F38L	LCP1_uc001vba.3_Missense_Mutation_p.F38L	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	38	EF-hand 1.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		AAGCAGCCTTGAACAAGTCAT	0.433			T	BCL6	NHL 								31	90					0	0	0	0	C	46733075	C	C	46733075	3	2	261	1	0	0	0	0	1	0	0	0	8731	1281	45	2	1825	2	LCP1	13	46733075	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3856235	46733075	68436803	326	47702											
SUCLA2	8803	broad.mit.edu	37	chr13	48563043	48563043	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actatcttcactcctcctttGaggccactttcaaatgttcc	8	15	4	14	0	3	1	2	1	1	0	6	1	6	1	4	1	0	1	4	1	2	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:48563043G>A	uc001vbs.2	-	3	402	c.345C>T	c.(343-345)CTC>CTT	p.L115L	SUCLA2_uc010tgb.1_Silent_p.L55L|SUCLA2_uc010tgc.1_5'UTR|SUCLA2_uc010tgd.1_Silent_p.L55L|SUCLA2_uc001vbt.1_RNA|SUCLA2_uc001vbu.1_Silent_p.L115L	NM_003850	NP_003841	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	115	ATP-grasp.				succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)	1		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	CTCCTCCTTTGAGGCCACTTT	0.328													37	118					0	0	0	0	A	48563043	A	A	48563043	2	1	261	1	0	0	0	0	0	0	0	1	15429	1277	45	2		2	SUCLA2	13	48563043	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1829968	48563043	66606835	327	47703											
PCDH17	27253	broad.mit.edu	37	chr13	58207078	58207078	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgacaacgcgccctccttctCctcggaccagatcgaaatgg	9	7	9	16	5	1	1	0	0	1	1	5	4	2	2	4	2	1	0	4	2	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:58207078C>G	uc001vhq.1	+	1	1290	c.398C>G	c.(397-399)TCC>TGC	p.S133C	PCDH17_uc010aec.1_Missense_Mutation_p.S133C	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	133	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCCTCCTTCTCCTCGGACCAG	0.612													6	11					0	0	0	0	G	58207078	G	G	58207078	3	3	261	1	0	0	0	0	1	0	0	0	11566	855	30	2	400	2	PCDH17	13	58207078	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	9644035	58207078	56962800	328	47704											
MYCBP2	23077	broad.mit.edu	37	chr13	77633702	77633702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgccaacagcagataactCtgttccactcctggaaccac	12	8	6	15	0	1	1	0	0	1	1	3	2	3	2	4	1	5	2	4	1	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:77633702C>T	uc001vkf.2	-	78	13073	c.12982G>A	c.(12982-12984)GAG>AAG	p.E4328K	MYCBP2_uc010aev.2_Missense_Mutation_p.E3732K|MYCBP2_uc001vke.2_Missense_Mutation_p.E945K	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GCAGATAACTCTGTTCCACTC	0.463													8	67					0	0	0	0	T	77633702	T	T	77633702	3	4	261	1	0	0	0	0	1	0	0	0	10071	922	32	2	968	2	MYCBP2	13	77633702	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	19426624	77633702	37536176	329	47705											
MYCBP2	23077	broad.mit.edu	37	chr13	77699528	77699528	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctagctaaggaccatgcctCtccttcatcactctcacaga	10	11	5	15	0	5	1	3	0	3	1	7	2	5	2	3	1	2	1	3	1	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:77699528C>G	uc001vkf.2	-	55	7937	c.7846G>C	c.(7846-7848)GAG>CAG	p.E2616Q	MYCBP2_uc010aev.2_Missense_Mutation_p.E2020Q|MYCBP2_uc001vkg.1_Missense_Mutation_p.E79Q	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GACCATGCCTCTCCTTCATCA	0.433													43	162					0	0	0	0	G	77699528	G	G	77699528	3	3	261	1	0	0	0	0	1	0	0	0	10071	922	32	2	6196	2	MYCBP2	13	77699528	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	65826	77699528	37470350	330	47706											
COL4A2	1284	broad.mit.edu	37	chr13	111077163	111077163	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggactgcagggacgtaaagGagacaagggtgaaaggggag	14	3	20	4	1	0	2	0	1	0	1	0	6	0	5	0	6	1	2	0	6	4	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:111077163G>A	uc001vqx.2	+	5	552	c.263G>A	c.(262-264)GGA>GAA	p.G88E		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	88					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGACGTAAAGGAGACAAGGGT	0.627													13	41					0	0	0	0	A	111077163	A	A	111077163	3	1	261	1	0	0	0	0	1	0	0	0	3705	1174	41	2	277	2	COL4A2	13	111077163	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	33377635	111077163	4092715	331	47707											
ADPRHL1	113622	broad.mit.edu	37	chr13	114079395	114079395	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcttctgcatcataattgTcggggaagatggctttattt	8	17	9	7	1	3	1	1	0	2	1	5	2	3	2	0	3	1	2	0	3	3	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:114079395T>C	uc001vtq.1	-	5	833	c.746A>G	c.(745-747)GAC>GGC	p.D249G	ADPRHL1_uc001vtp.1_Missense_Mutation_p.D167G	NM_138430	NP_612439	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1 isoform 1	249					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			ATCATAATTGTCGGGGAAGAT	0.299													15	69					0	0	0	0	C	114079395	C	C	114079395	3	2	261	1	0	0	0	0	1	0	0	0	332	1667	58	5	330	5	ADPRHL1	13	114079395	Missense_Mutation	SNP	T	TCGA-CV-7427-01A-11D-2078-08	3002232	114079395	1090483	332	47708											
RASA3	22821	broad.mit.edu	37	chr13	114781703	114781703	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaggttttctccgtctttCaacttcacagggtcgatttc	7	16	7	11	2	5	0	3	0	2	0	8	1	5	0	1	2	1	1	1	2	2	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:114781703C>T	uc001vui.2	-	13	1382	c.1251G>A	c.(1249-1251)TTG>TTA	p.L417L	RASA3_uc010tkk.1_Silent_p.L385L|RASA3_uc001vuj.2_Silent_p.L34L	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	417	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			CTCCGTCTTTCAACTTCACAG	0.517													10	44					0	0	0	0	T	114781703	T	T	114781703	2	4	261	1	0	0	0	0	0	0	0	1	13127	825	29	2		2	RASA3	13	114781703	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	702308	114781703	388175	333	47709											
HOMEZ	57594	broad.mit.edu	37	chr14	23745036	23745036	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgggctgcccagtacctCtccaagggttgtatatccgg	6	11	13	11	1	1	0	0	0	1	0	3	0	2	0	4	4	2	4	4	4	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:23745036C>T	uc001wja.2	-	2	1549	c.1401G>A	c.(1399-1401)GAG>GAA	p.E467E	HOMEZ_uc001wjb.2_Silent_p.E469E	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	467						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CCCAGTACCTCTCCAAGGGTT	0.552													6	31					0	0	0	0	T	23745036	T	T	23745036	2	4	261	1	0	0	0	0	0	0	0	1	7320	912	32	2		2	HOMEZ	14	23745036	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08		23745036	83604504	334	47710											
L2HGDH	79944	broad.mit.edu	37	chr14	50734600	50734600	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccttggtgtgaagtgaactCctaggaaaggaaaccggcta	12	9	12	8	1	0	2	0	2	0	0	2	4	2	4	3	4	2	1	3	4	6	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:50734600C>T	uc001wxu.2	-	8	1014	c.935G>A	c.(934-936)GGA>GAA	p.G312E	L2HGDH_uc010tqn.1_Missense_Mutation_p.G312E|L2HGDH_uc010tqo.1_Missense_Mutation_p.G312E	NM_024884	NP_079160	Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase precursor	312					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)					GAAGTGAACTCCTAGGAAAGG	0.423													27	65					0	0	0	0	T	50734600	T	T	50734600	3	4	261	1	0	0	0	0	1	0	0	0	8630	855	30	2	468	2	L2HGDH	14	50734600	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	26989564	50734600	56614940	335	47711											
DAAM1	23002	broad.mit.edu	37	chr14	59821922	59821922	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agaggtgtttaggagtggtgCcctcaagcagttgctggagg	8	10	17	6	0	1	1	1	0	0	1	1	3	1	3	1	5	3	4	1	5	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:59821922C>T	uc001xdz.1	+	21	2551	c.2426C>T	c.(2425-2427)GCC>GTC	p.A809V	DAAM1_uc001xea.1_Missense_Mutation_p.A799V|DAAM1_uc001xec.1_RNA	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	809	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AGGAGTGGTGCCCTCAAGCAG	0.378													40	118					0	0	0	0	T	59821922	T	T	59821922	3	4	261	1	0	0	0	0	1	0	0	0	4232	739	26	4	2504	4	DAAM1	14	59821922	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	9087322	59821922	47527618	336	47712											
SYNE2	23224	broad.mit.edu	37	chr14	64691209	64691209	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacccctgcccagcttcgacGaggtagactcgggggaccag	8	5	13	15	3	0	1	0	0	0	1	2	4	0	2	4	3	2	2	4	3	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:64691209G>C	uc001xgm.2	+	113	20574	c.20344G>C	c.(20344-20346)GAG>CAG	p.E6782Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E6805Q|SYNE2_uc010apy.2_Missense_Mutation_p.E3167Q|SYNE2_uc001xgn.2_Missense_Mutation_p.E1744Q|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.E752Q|SYNE2_uc001xgq.2_Missense_Mutation_p.E1161Q|SYNE2_uc001xgr.2_Missense_Mutation_p.E565Q|SYNE2_uc010tsi.1_Missense_Mutation_p.E439Q|SYNE2_uc001xgs.2_Missense_Mutation_p.E453Q|SYNE2_uc001xgt.2_Missense_Mutation_p.E327Q	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6782	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAGCTTCGACGAGGTAGACTC	0.517													9	83					0	0	0	0	C	64691209	C	C	64691209	3	2	261	1	0	0	0	0	1	0	0	0	15512	1059	37	3	20905	3	SYNE2	14	64691209	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4869287	64691209	42658331	337	47713											
SLC8A3	6547	broad.mit.edu	37	chr14	70518823	70518823	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccatagtcagcttcctgtCtgtcacatctgcaacaaaac	11	12	5	13	0	4	0	2	0	2	0	6	0	6	0	2	0	4	2	2	0	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:70518823C>G	uc001xly.2	-	5	2669	c.1915G>C	c.(1915-1917)GAC>CAC	p.D639H	SLC8A3_uc001xlu.2_5'UTR|SLC8A3_uc001xlv.2_Missense_Mutation_p.D10H|SLC8A3_uc001xlw.2_Splice_Site_p.D636_splice|SLC8A3_uc001xlx.2_Splice_Site_p.D637_splice|SLC8A3_uc001xlz.2_Missense_Mutation_p.D633H|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_5'UTR	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	639	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGCTTCCTGTCTGTCACATCT	0.458													24	59					0	0	0	0	G	70518823	G	G	70518823	3	3	261	1	0	0	0	0	1	0	0	0	14772	927	32	2	884	2	SLC8A3	14	70518823	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5827614	70518823	36830717	338	47714											
YLPM1	56252	broad.mit.edu	37	chr14	75279341	75279341	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggaatcctaggagaacgaagGacttatcctgaggagcgaat	14	7	13	7	2	0	2	0	1	0	1	2	8	2	5	2	4	2	0	2	4	6	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:75279341G>C	uc001xqj.3	+	11	5482	c.5358G>C	c.(5356-5358)AGG>AGC	p.R1786S	YLPM1_uc001xql.3_RNA|YLPM1_uc001xqm.1_Missense_Mutation_p.R269S	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GAGAACGAAGGACTTATCCTG	0.443													5	8					0	0	0	0	C	75279341	C	C	75279341	3	2	261	1	0	0	0	0	1	0	0	0	17554	1165	41	2	5400	2	YLPM1	14	75279341	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4760518	75279341	32070199	339	47715											
C14orf166B	145497	broad.mit.edu	37	chr14	77319682	77319682	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctggatatcggtggcaatGacatcggcaatgaaggggcc	11	7	14	9	2	0	2	0	2	0	0	2	3	0	3	2	6	0	2	2	6	4	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:77319682G>C	uc001xsx.2	+	9	1051	c.937G>C	c.(937-939)GAC>CAC	p.D313H	C14orf166B_uc010asn.1_Missense_Mutation_p.D73H|C14orf166B_uc001xsw.2_RNA|C14orf166B_uc010tvg.1_RNA|C14orf166B_uc010tvh.1_RNA	NM_194287	NP_919263	Q0VAA2	CN16B_HUMAN	hypothetical protein LOC145497	313	LRR 7.										0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		CGGTGGCAATGACATCGGCAA	0.507													12	36					0	0	0	0	C	77319682	C	C	77319682	3	2	261	1	0	0	0	0	1	0	0	0	1763	1290	45	2	971	2	C14orf166B	14	77319682	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2040341	77319682	30029858	340	47716											
C14orf166B	145497	broad.mit.edu	37	chr14	77319694	77319694	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggcaatgacatcggcaatGaaggggcctccaaaatcagc	13	6	12	10	1	1	2	1	2	0	0	3	2	2	2	2	4	1	2	2	4	5	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:77319694G>A	uc001xsx.2	+	9	1063	c.949G>A	c.(949-951)GAA>AAA	p.E317K	C14orf166B_uc010asn.1_Missense_Mutation_p.E77K|C14orf166B_uc001xsw.2_RNA|C14orf166B_uc010tvg.1_RNA|C14orf166B_uc010tvh.1_RNA	NM_194287	NP_919263	Q0VAA2	CN16B_HUMAN	hypothetical protein LOC145497	317	LRR 7.										0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		CATCGGCAATGAAGGGGCCTC	0.478													7	26					0	0	0	0	A	77319694	A	A	77319694	3	1	261	1	0	0	0	0	1	0	0	0	1763	1291	45	2	983	2	C14orf166B	14	77319694	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	12	77319694	30029846	341	47717											
PTPN21	11099	broad.mit.edu	37	chr14	88935898	88935898	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcaggccagtctgtgtattgGaggtgccagacggtcctctc	6	11	13	11	1	3	1	1	0	2	1	5	2	4	2	3	4	1	1	3	4	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:88935898G>T	uc001xwv.3	-	17	3511	c.3180C>A	c.(3178-3180)CTC>CTA	p.L1060L	PTPN21_uc010twc.1_Silent_p.L856L	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	1060	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						CTGTGTATTGGAGGTGCCAGA	0.537													5	53					2.7689e-08	2.94958e-08	1	0	T	88935898	T	T	88935898	2	4	261	1	0	0	0	0	0	0	0	1	12851	1161	41	2		2	PTPN21	14	88935898	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	11616204	88935898	18413642	342	47718											
C14orf184	650662	broad.mit.edu	37	chr14	92040776	92040776	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgggtgacagccgccgctCgggtgtactgttcgctctct	4	10	14	13	5	1	1	0	1	1	0	4	1	1	1	2	2	3	4	2	2	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:92040776C>T	uc010aua.1	-	1	608	c.181G>A	c.(181-183)GAG>AAG	p.E61K		NM_001080113	NP_001073582	Q8WYT3	CN184_HUMAN	hypothetical protein LOC650662	61											0						AGCCGCCGCTCGGGTGTACTG	0.657													5	8					0	0	0	0	T	92040776	T	T	92040776	3	4	261	1	0	0	0	0	1	0	0	0	1773	893	31	1	269	1	C14orf184	14	92040776	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3104878	92040776	15308764	343	47719											
DDX24	57062	broad.mit.edu	37	chr14	94528623	94528623	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagattttcctcctcattctCattctgtttgggaacaggtt	8	17	7	9	0	3	1	2	0	2	1	6	2	5	2	2	2	1	2	2	2	2	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:94528623C>G	uc001ycj.2	-	3	1162	c.1063G>C	c.(1063-1065)GAG>CAG	p.E355Q	DDX24_uc010twq.1_Missense_Mutation_p.E312Q|DDX24_uc010twr.1_Missense_Mutation_p.E105Q	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	355	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		TCCTCATTCTCATTCTGTTTG	0.483													23	70					0	0	0	0	G	94528623	G	G	94528623	3	3	261	1	0	0	0	0	1	0	0	0	4368	835	29	2	1544	2	DDX24	14	94528623	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2487847	94528623	12820917	344	47720											
SETD3	84193	broad.mit.edu	37	chr14	99929847	99929847	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgctttttccgtattttctCaaccagagtccggatctgca	7	16	7	11	2	2	1	1	0	2	1	5	2	4	2	3	1	3	3	3	1	2	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:99929847C>G	uc001ygc.2	-	3	342	c.172G>C	c.(172-174)GAG>CAG	p.E58Q	SETD3_uc001ygd.2_Missense_Mutation_p.E58Q|SETD3_uc001ygf.2_Missense_Mutation_p.E58Q	NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	58					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				CGTATTTTCTCAACCAGAGTC	0.413													4	22					0	0	0	0	G	99929847	G	G	99929847	3	3	261	1	0	0	0	0	1	0	0	0	14197	835	29	2	1702	2	SETD3	14	99929847	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5401224	99929847	7419693	345	47721											
EML1	2009	broad.mit.edu	37	chr14	100405558	100405558	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtggccagaaggctcggacgGaaccgacatcaatgccgtct	10	6	13	12	4	2	1	1	0	1	1	3	4	2	3	3	4	2	1	3	4	3	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:100405558G>A	uc001ygs.2	+	21	2285	c.2216G>A	c.(2215-2217)GGA>GAA	p.G739E	EML1_uc010tww.1_Missense_Mutation_p.G727E|EML1_uc001ygr.2_Missense_Mutation_p.G758E	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	739	WD 10.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GGCTCGGACGGAACCGACATC	0.587													4	40					0	0	0	0	A	100405558	A	A	100405558	3	1	261	1	0	0	0	0	1	0	0	0	5120	1174	41	2	2359	2	EML1	14	100405558	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	475711	100405558	6943982	346	47722											
EML1	2009	broad.mit.edu	37	chr14	100405590	100405590	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgccgtctgtcgggcccatGagaagaaactcctgtcaaca	11	8	10	12	2	2	2	1	1	1	2	4	3	3	2	3	1	3	0	3	1	3	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:100405590G>C	uc001ygs.2	+	21	2317	c.2248G>C	c.(2248-2250)GAG>CAG	p.E750Q	EML1_uc010tww.1_Missense_Mutation_p.E738Q|EML1_uc001ygr.2_Missense_Mutation_p.E769Q	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	750	WD 10.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				TCGGGCCCATGAGAAGAAACT	0.537													4	33					0	0	0	0	C	100405590	C	C	100405590	3	2	261	1	0	0	0	0	1	0	0	0	5120	1291	45	2	2391	2	EML1	14	100405590	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	32	100405590	6943950	347	47723											
C14orf68	283600	broad.mit.edu	37	chr14	100789775	100789775	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gattttgtcgctggagccatCggaggtaacagacaggatgg	10	9	15	7	2	0	1	0	0	0	1	2	5	0	4	1	5	2	2	1	5	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:100789775C>T	uc001yhc.2	+	1	97	c.24C>T	c.(22-24)ATC>ATT	p.I8I	C14orf68_uc001yhd.2_5'UTR	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	8	Solcar 1.|Helical; Name=1; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				CTGGAGCCATCGGAGGTAACA	0.627													13	17					0	0	0	0	T	100789775	T	T	100789775	2	4	261	1	0	0	0	0	0	0	0	1	1784	874	31	1		1	C14orf68	14	100789775	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	384185	100789775	6559765	348	47724											
DYNC1H1	1778	broad.mit.edu	37	chr14	102455173	102455173	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agttagtcacaagcctggtgGagagccaaagatcaaagtga	15	7	12	7	0	2	3	2	1	0	2	2	4	2	3	2	2	2	1	2	2	4	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:102455173G>C	uc001yks.2	+	10	3016	c.2852G>C	c.(2851-2853)GGA>GCA	p.G951A		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	951	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						AAGCCTGGTGGAGAGCCAAAG	0.398													11	30					0	0	0	0	C	102455173	C	C	102455173	3	2	261	1	0	0	0	0	1	0	0	0	4863	1174	41	2	2890	2	DYNC1H1	14	102455173	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1665398	102455173	4894367	349	47725											
HSP90AA1	3320	broad.mit.edu	37	chr14	102549502	102549502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttctttggtgactgacaCtaaagtcttcccctcaaatt	9	14	6	12	0	3	2	1	2	2	0	4	2	4	2	3	1	0	0	3	1	3	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:102549502C>T	uc001yku.3	-	9	1814	c.1624G>A	c.(1624-1626)GTG>ATG	p.V542M	HSP90AA1_uc001ykv.3_Missense_Mutation_p.V664M|HSP90AA1_uc001ykw.1_Missense_Mutation_p.V363M|HSP90AA1_uc001ykx.1_Missense_Mutation_p.V531M	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	542					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	GTGACTGACACTAAAGTCTTC	0.274													22	77					0	0	0	0	T	102549502	T	T	102549502	3	4	261	1	0	0	0	0	1	0	0	0	7440	565	20	4	586	4	HSP90AA1	14	102549502	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	94329	102549502	4800038	350	47726											
TNFAIP2	7127	broad.mit.edu	37	chr14	103596165	103596165	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccaggcagatccgactgctgGaggccacattcctgtccagt	8	8	11	14	1	0	1	0	0	0	1	3	3	3	2	5	3	1	2	5	3	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:103596165G>A	uc001ymm.1	+	3	1080	c.949G>A	c.(949-951)GAG>AAG	p.E317K	TNFAIP2_uc010awo.1_Intron|TNFAIP2_uc010txz.1_Intron|TNFAIP2_uc010tya.1_5'Flank	NM_006291	NP_006282	Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	317					angiogenesis|cell differentiation	extracellular space				central_nervous_system(1)	1		Melanoma(154;0.155)	Epithelial(46;0.191)			CCGACTGCTGGAGGCCACATT	0.662													7	19					0	0	0	0	A	103596165	A	A	103596165	3	1	261	1	0	0	0	0	1	0	0	0	16339	1175	41	2	959	2	TNFAIP2	14	103596165	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1046663	103596165	3753375	351	47727											
KLC1	3831	broad.mit.edu	37	chr14	104129155	104129155	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgcctcgcaggggcgctacGaggtagctgtgcccctctgc	5	7	14	15	4	1	0	0	0	1	0	2	1	1	0	3	3	4	4	3	3	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:104129155G>A	uc001yno.2	+	5	996	c.688G>A	c.(688-690)GAG>AAG	p.E230K	KLC1_uc010tyd.1_Missense_Mutation_p.E389K|KLC1_uc010tye.1_Missense_Mutation_p.E226K|KLC1_uc001ynm.1_Missense_Mutation_p.E230K|KLC1_uc001ynn.1_Missense_Mutation_p.E226K|KLC1_uc010tyf.1_Missense_Mutation_p.E230K	NM_182923	NP_891553	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 2	230	TPR 1.				blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				GGGGCGCTACGAGGTAGCTGT	0.672													9	19					0	0	0	0	A	104129155	A	A	104129155	3	1	261	1	0	0	0	0	1	0	0	0	8372	1059	37	1	702	1	KLC1	14	104129155	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	532990	104129155	3220385	352	47728											
OIP5	11339	broad.mit.edu	37	chr15	41602045	41602045	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttagcactatcttctctttCagctaggaagagaaatatat	13	14	7	7	0	3	1	1	0	2	1	4	3	3	2	0	1	2	3	0	1	7	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:41602045C>G	uc001znp.2	-	5	657	c.597G>C	c.(595-597)CTG>CTC	p.L199L		NM_007280	NP_009211	O43482	MS18B_HUMAN	Opa interacting protein 5	199					cell communication|cell division|CenH3-containing nucleosome assembly at centromere|mitosis	Cajal body|chromatin|chromosome, centromeric region	protein binding				0		all_cancers(109;4.16e-14)|all_epithelial(112;7.09e-12)|Lung NSC(122;1.14e-09)|all_lung(180;2.56e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)		OV - Ovarian serous cystadenocarcinoma(18;1.49e-16)|GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.163)		TCTTCTCTTTCAGCTAGGAAG	0.274													20	54					0	0	0	0	G	41602045	G	G	41602045	2	3	261	1	0	0	0	0	0	0	0	1	10902	813	29	2		2	OIP5	15	41602045	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08		41602045	60929347	353	47729											
CKMT1B	1159	broad.mit.edu	37	chr15	43891383	43891383	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggtgcaactggtcatcgatgGagtaaactatttgattgatt	11	14	11	5	1	1	2	1	2	0	0	2	4	1	3	0	3	3	2	0	3	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:43891383G>C	uc001zsc.2	+	10	1558	c.1166G>C	c.(1165-1167)GGA>GCA	p.G389A	CKMT1B_uc010uds.1_Missense_Mutation_p.G420A|CKMT1B_uc001zsd.3_Missense_Mutation_p.G389A|CKMT1B_uc010bdj.2_RNA	NM_020990	NP_066270	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1B precursor	389	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	GTCATCGATGGAGTAAACTAT	0.488													55	119					0	0	0	0	C	43891383	C	C	43891383	3	2	261	1	0	0	0	0	1	0	0	0	3465	1174	41	2	1200	2	CKMT1B	15	43891383	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2289338	43891383	58640009	354	47730											
SECISBP2L	9728	broad.mit.edu	37	chr15	49327631	49327631	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcagtgcattctgtggtgAtagcatttacagtatttgca	9	15	10	7	0	2	1	1	1	1	0	2	1	2	1	0	1	4	5	0	1	3	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:49327631A>G	uc001zxe.1	-	3	562	c.428T>C	c.(427-429)ATC>ACC	p.I143T	SECISBP2L_uc001zxd.1_Missense_Mutation_p.I143T|SECISBP2L_uc010bep.1_5'UTR|SECISBP2L_uc010beq.1_Missense_Mutation_p.I143T	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	143										breast(1)|skin(1)	2						TTCTGTGGTGATAGCATTTAC	0.483													24	95					0	0	0	0	G	49327631	G	G	49327631	3	3	261	1	0	0	0	0	1	0	0	0	14072	333	12	5	2802	5	SECISBP2L	15	49327631	Missense_Mutation	SNP	A	TCGA-CV-7427-01A-11D-2078-08	5436248	49327631	53203761	355	47731											
TMOD2	29767	broad.mit.edu	37	chr15	52069169	52069169	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgctcaacaatccaaagttCgatgaagaaacagccaacaa	18	7	6	10	1	1	2	1	1	0	1	3	3	2	2	2	0	5	2	2	0	7	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:52069169C>T	uc002abk.2	+	5	668	c.447C>T	c.(445-447)TTC>TTT	p.F149F	TMOD2_uc002abl.3_Silent_p.F149F|TMOD2_uc010bfb.2_Silent_p.F105F	NM_014548	NP_055363	Q9NZR1	TMOD2_HUMAN	neuronal tropomodulin isoform a	149					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(2)	2				all cancers(107;0.00435)		ATCCAAAGTTCGATGAAGAAA	0.413													13	38					0	0	0	0	T	52069169	T	T	52069169	2	4	261	1	0	0	0	0	0	0	0	1	16300	883	31	1		1	TMOD2	15	52069169	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2741538	52069169	50462223	356	47732											
KIAA1370	56204	broad.mit.edu	37	chr15	52905993	52905993	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgttcgtccttctgttatCagcaaggccaaagagaccaa	11	10	10	10	1	2	1	1	0	1	1	4	2	3	1	3	2	1	3	3	2	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:52905993C>T	uc002acg.3	-	3	231	c.78G>A	c.(76-78)CTG>CTA	p.L26L	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Intron|KIAA1370_uc010ugf.1_Silent_p.L33L	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	26											0				all cancers(107;0.0803)		CTTCTGTTATCAGCAAGGCCA	0.408													11	27					0	0	0	0	T	52905993	T	T	52905993	2	4	261	1	0	0	0	0	0	0	0	1	8265	813	29	2		2	KIAA1370	15	52905993	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	836824	52905993	49625399	357	47733											
ZNF609	23060	broad.mit.edu	37	chr15	64791723	64791723	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attggagtagggaatctcatCattgacctggacgccgatct	10	11	11	9	2	3	1	2	1	2	0	4	5	3	4	2	3	0	1	2	3	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:64791723C>T	uc002ann.2	+	1	105	c.105C>T	c.(103-105)ATC>ATT	p.I35I	ZNF609_uc010bgy.2_Silent_p.I35I	NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	35						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GGAATCTCATCATTGACCTGG	0.547													16	61					0	0	0	0	T	64791723	T	T	64791723	2	4	261	1	0	0	0	0	0	0	0	1	18102	816	29	2		2	ZNF609	15	64791723	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	11885730	64791723	37739669	358	47734											
CLPX	10845	broad.mit.edu	37	chr15	65458988	65458988	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccttcttagggggaggtggtGgtttctgttggaatgccaat	6	14	15	6	0	2	0	0	0	2	0	2	2	2	2	2	6	1	2	2	6	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:65458988G>C	uc002aom.2	-	4	566	c.494C>G	c.(493-495)CCA>CGA	p.P165R	CLPX_uc010uiu.1_RNA|CLPX_uc010bhg.1_Missense_Mutation_p.P165R	NM_006660	NP_006651	O76031	CLPX_HUMAN	ClpX caseinolytic protease X homolog precursor	165					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding				0						GGGAGGTGGTGGTTTCTGTTG	0.378													52	137					0	0	0	0	C	65458988	C	C	65458988	3	2	261	1	0	0	0	0	1	0	0	0	3571	1348	47	4	1451	4	CLPX	15	65458988	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	667265	65458988	37072404	359	47735											
CILP	8483	broad.mit.edu	37	chr15	65499240	65499240	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctggccagtgctgcccgCaggtgtccagtcagtggtcc	5	8	13	15	1	1	0	1	0	0	0	3	0	3	0	5	3	2	2	5	3	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:65499240C>T	uc002aon.2	-	4	485	c.304G>A	c.(304-306)GCG>ACG	p.A102T		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	102					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						GTGCTGCCCGCAGGTGTCCAG	0.627													6	24					0	0	0	0	T	65499240	T	T	65499240	3	4	261	1	0	0	0	0	1	0	0	0	3444	710	25	4	3274	4	CILP	15	65499240	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	40252	65499240	37032152	360	47736											
SMAD3	4088	broad.mit.edu	37	chr15	67482843	67482843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtcctcacccagatgggctCcccaagcatccgctgttcca	7	8	9	17	1	1	1	1	0	0	1	5	1	5	1	6	2	1	4	6	2	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:67482843C>T	uc002aqj.2	+	9	1545	c.1247C>T	c.(1246-1248)TCC>TTC	p.S416F	SMAD3_uc010ujr.1_Missense_Mutation_p.S311F|SMAD3_uc010ujs.1_Missense_Mutation_p.S372F|SMAD3_uc010ujt.1_Missense_Mutation_p.S221F	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	416	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CAGATGGGCTCCCCAAGCATC	0.547													14	15					0	0	0	0	T	67482843	T	T	67482843	3	4	261	1	0	0	0	0	1	0	0	0	14823	855	30	2	1359	2	SMAD3	15	67482843	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1983603	67482843	35048549	361	47737											
HCN4	10021	broad.mit.edu	37	chr15	73615835	73615835	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggctcagtccagcgggggCagagaatccagccagctgtt	8	7	15	11	1	1	1	1	0	0	1	3	2	3	1	3	3	3	4	3	3	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:73615835C>A	uc002avp.2	-	8	3593	c.2599G>T	c.(2599-2601)GCC>TCC	p.A867S		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	867	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		CCAGCGGGGGCAGAGAATCCA	0.692													8	38					0.000157383	0.000163614	1	0	A	73615835	A	A	73615835	3	1	261	1	0	0	0	0	1	0	0	0	7038	710	25	4	1016	4	HCN4	15	73615835	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	6132992	73615835	28915557	362	47738											
HCN4	10021	broad.mit.edu	37	chr15	73616079	73616079	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccacagaagtggtggcagcGgcagcctgcagtggtgcctg	7	6	17	11	1	0	1	0	0	0	1	0	1	0	1	3	4	4	3	3	4	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:73616079G>A	uc002avp.2	-	8	3349	c.2355C>T	c.(2353-2355)GCC>GCT	p.A785A		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	785	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		TGGTGGCAGCGGCAGCCTGCA	0.701													8	26					0	0	0	0	A	73616079	A	A	73616079	2	1	261	1	0	0	0	0	0	0	0	1	7038	1103	39	1		1	HCN4	15	73616079	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	244	73616079	28915313	363	47739											
PML	5371	broad.mit.edu	37	chr15	74325651	74325651	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcacctccaaggcagtctCaccaccccacctggatggac	10	5	8	18	0	1	0	1	0	1	0	3	2	2	2	6	3	1	2	6	3	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:74325651C>T	uc002awv.2	+	6	1693	c.1553C>T	c.(1552-1554)TCA>TTA	p.S518L	PML_uc002awm.2_Missense_Mutation_p.S518L|PML_uc002awl.2_Intron|PML_uc002awj.1_Missense_Mutation_p.S470L|PML_uc002awk.2_Missense_Mutation_p.S518L|PML_uc002awn.2_Missense_Mutation_p.S518L|PML_uc002awo.2_Missense_Mutation_p.S470L|PML_uc002awp.2_Intron|PML_uc002awq.2_Missense_Mutation_p.S518L|PML_uc002awr.2_Missense_Mutation_p.S518L|PML_uc002aws.2_Missense_Mutation_p.S470L|PML_uc002awt.2_Intron|PML_uc002awu.2_Missense_Mutation_p.S470L|PML_uc010ule.1_Missense_Mutation_p.S79L|PML_uc002awx.2_Missense_Mutation_p.S228L|PML_uc002awy.2_5'UTR	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	518					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						AAGGCAGTCTCACCACCCCAC	0.657			T	RARA|PAX5	APL|ALL								9	28					0	0	0	0	T	74325651	T	T	74325651	3	4	261	1	0	0	0	0	1	0	0	0	12190	838	29	2	1575	2	PML	15	74325651	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	709572	74325651	28205741	364	47740											
GOLGA6A	342096	broad.mit.edu	37	chr15	74365132	74365132	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggtctctagctgttggttCtggtggctggcagcttctag	3	15	15	8	0	3	0	0	0	3	0	4	0	3	0	0	5	2	6	0	5	2	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:74365132C>G	uc002axa.1	-	13	1493	c.1452G>C	c.(1450-1452)CAG>CAC	p.Q484H		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	484	Potential.										0						GCTGTTGGTTCTGGTGGCTGG	0.622													5	85					0	0	0	0	G	74365132	G	G	74365132	3	3	261	1	0	0	0	0	1	0	0	0	6594	912	32	2	653	2	GOLGA6A	15	74365132	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	39481	74365132	28166260	365	47741											
SGK269	79834	broad.mit.edu	37	chr15	77471990	77471990	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcactgtgcttgctttctctCtggtgctgctgctgcccacc	2	14	10	15	0	2	0	0	0	2	0	3	0	2	0	2	1	6	6	2	1	0	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:77471990C>T	uc002bcm.2	-	3	2587	c.2279G>A	c.(2278-2280)AGA>AAA	p.R760K	SGK269_uc002bcn.2_Missense_Mutation_p.R760K	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	760					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TGCTTTCTCTCTGGTGCTGCT	0.537													32	72					0	0	0	0	T	77471990	T	T	77471990	3	4	261	1	0	0	0	0	1	0	0	0	14276	913	32	2	2977	2	SGK269	15	77471990	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3106858	77471990	25059402	366	47742											
CPEB1	64506	broad.mit.edu	37	chr15	83221346	83221346	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggacagacttctctagttCgaagaccagatacacatacc	13	9	7	12	2	1	3	0	0	1	3	4	5	1	4	2	1	2	1	2	1	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:83221346C>A	uc002bit.2	-	8	1416	c.1279G>T	c.(1279-1281)GAA>TAA	p.E427*	CPEB1_uc002biq.2_Nonsense_Mutation_p.E287*|CPEB1_uc002bir.2_Nonsense_Mutation_p.E292*|CPEB1_uc002bis.2_Nonsense_Mutation_p.E287*|CPEB1_uc010uod.1_Nonsense_Mutation_p.E136*|CPEB1_uc010uoe.1_Nonsense_Mutation_p.E365*|CPEB1_uc002biu.2_Nonsense_Mutation_p.E389*|CPEB1_uc010uof.1_Nonsense_Mutation_p.E287*|CPEB1_uc002biv.2_Nonsense_Mutation_p.E362*|CPEB1_uc002bip.2_Nonsense_Mutation_p.E136*	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	367	RRM 1.|Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			TTCTCTAGTTCGAAGACCAGA	0.493													18	56					4.96729e-08	5.25437e-08	1	0	A	83221346	A	A	83221346	4	1	261	1	0	0	0	0	0	1	0	0	3815	893	31	3	621	3	CPEB1	15	83221346	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5749356	83221346	19310046	367	47743											
POLG	5428	broad.mit.edu	37	chr15	89862269	89862269	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcaagcttattgaacatttCtgactctgtgccccccttcc	7	14	5	15	0	3	2	1	2	2	0	4	2	4	2	4	0	3	1	4	0	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:89862269C>T	uc002bns.3	-	20	3448	c.3166G>A	c.(3166-3168)GAA>AAA	p.E1056K	POLG_uc002bnr.3_Missense_Mutation_p.E1056K	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	1056					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			TTGAACATTTCTGACTCTGTG	0.562								DNA_polymerases_(catalytic_subunits)					6	93					0	0	0	0	T	89862269	T	T	89862269	3	4	261	1	0	0	0	0	1	0	0	0	12255	922	32	2	569	2	POLG	15	89862269	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	6640923	89862269	12669123	368	47744											
PRC1	9055	broad.mit.edu	37	chr15	91510405	91510405	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggattccagaagtagcatCagatttggaagcctttgaaa	14	10	11	6	0	1	3	1	1	0	2	2	6	2	5	2	2	2	2	2	2	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:91510405C>G	uc002bqm.2	-	15	1976	c.1819G>C	c.(1819-1821)GAT>CAT	p.D607H	PRC1_uc002bqn.2_Missense_Mutation_p.D593H|PRC1_uc002bqo.2_Nonstop_Mutation_p.*567S|PRC1_uc010uqs.1_Nonstop_Mutation_p.*526S	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	607	Unstructured, Arg/Lys rich.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					GAAGTAGCATCAGATTTGGAA	0.448													22	55					0	0	0	0	G	91510405	G	G	91510405	3	3	261	1	0	0	0	0	1	0	0	0	12508	838	29	2	47	2	PRC1	15	91510405	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1648136	91510405	11020987	369	47745											
XYLT1	64131	broad.mit.edu	37	chr16	17235129	17235129	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaaccagtccgaaccgccatCcacggcaatgccctctggga	10	5	10	16	3	1	0	0	0	1	0	3	3	3	1	6	2	3	1	6	2	3	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:17235129C>G	uc002dfa.2	-	7	1553	c.1468G>C	c.(1468-1470)GAT>CAT	p.D490H		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	490	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GAACCGCCATCCACGGCAATG	0.567													38	102					0	0	0	0	G	17235129	G	G	17235129	3	3	261	1	0	0	0	0	1	0	0	0	17531	855	30	2	1435	2	XYLT1	16	17235129	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08		17235129	73119624	370	47746											
CD2BP2	10421	broad.mit.edu	37	chr16	30365574	30365574	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcatcatcctcctcctcatCgctatccaaagagtgtttgc	9	13	5	14	1	3	1	3	0	0	1	8	1	7	1	4	0	1	2	4	0	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:30365574C>T	uc002dxr.2	-	2	401	c.148G>A	c.(148-150)GAT>AAT	p.D50N	CD2BP2_uc002dxs.2_Missense_Mutation_p.D50N	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	50					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						TCCTCCTCATCGCTATCCAAA	0.527													61	189					0	0	0	0	T	30365574	T	T	30365574	3	4	261	1	0	0	0	0	1	0	0	0	3010	884	31	1	897	1	CD2BP2	16	30365574	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	13130445	30365574	59989179	371	47747											
SLC5A2	6524	broad.mit.edu	37	chr16	31499472	31499472	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcatggtcatgccaggcatGatcagccgcattctgtaccc	8	10	9	14	1	4	1	3	1	1	0	4	1	4	1	3	2	3	3	3	2	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:31499472G>C	uc002ecf.3	+	8	1018	c.999G>C	c.(997-999)ATG>ATC	p.M333I	SLC5A2_uc010car.2_RNA|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	333	Helical; (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						TGCCAGGCATGATCAGCCGCA	0.627													24	90					0	0	0	0	C	31499472	C	C	31499472	3	2	261	1	0	0	0	0	1	0	0	0	14729	1290	45	2	1029	2	SLC5A2	16	31499472	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1133898	31499472	58855281	372	47748											
LONP2	83752	broad.mit.edu	37	chr16	48286135	48286135	+	Frame_Shift_Del	DEL	G	-	-																															acaggcctatgccgtttccaGattgtacaggtcttaaaaga																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:48286135delG	uc002efi.1	+	2	416	c.327delG	c.(325-327)CAGfs	p.Q109fs	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Frame_Shift_Del_p.Q109fs	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	109	Lon.				misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						GCCGTTTCCAGATTGTACAGG	0.507													---	---	---								-	48286135	-	-	48286135	7	5	261	1	0	1	0	1	0	0	0	0	8943	933	33	0	333	0	LONP2	16	48286135	Frame_Shift_Del	DEL	G	TCGA-CV-7427-01A-11D-2078-08	16786663	48286135	42068618	373	47749											
OGFOD1	55239	broad.mit.edu	37	chr16	56492471	56492471	+	Missense_Mutation	SNP	G	C	C																															atgatcaagtctgatgatttGaagaagagaagagagcctca																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:56492471G>C	uc002ejb.2	+	3	413	c.312G>C	c.(310-312)TTG>TTC	p.L104F	OGFOD1_uc002ejc.2_5'UTR	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	104							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	CTGATGATTTGAAGAAGAGAA	0.279													7	31					0	0	0	0	C	56492471	C	C	56492471	3	2	261	1	0	0	0	0	1	0	0	0	10895	1281	45	2	322	2	OGFOD1	16	56492471	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	8206336	56492471	33862282	374	47750	103	2									
OGFOD1	55239	broad.mit.edu	37	chr16	56492479	56492479	+	Missense_Mutation	SNP	G	A	A																															gtctgatgatttgaagaagaGaagagagcctcacatctcca																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:56492479G>A	uc002ejb.2	+	3	421	c.320G>A	c.(319-321)AGA>AAA	p.R107K	OGFOD1_uc002ejc.2_5'UTR	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	107							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	TTGAAGAAGAGAAGAGAGCCT	0.259													7	31					0	0	0	0	A	56492479	A	A	56492479	3	1	261	1	0	0	0	0	1	0	0	0	10895	942	33	2	330	2	OGFOD1	16	56492479	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	8	56492479	33862274	375	47751	103	2									
BBS2	583	broad.mit.edu	37	chr16	56535295	56535295	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaaatgcgtaattctgtatGagcagtttgggtctcattcc	9	14	11	7	1	2	1	1	1	2	0	4	2	3	2	1	2	2	4	1	2	3	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:56535295G>C	uc002ejd.2	-	10	1429	c.1195C>G	c.(1195-1197)CAT>GAT	p.H399D	BBS2_uc010ccg.2_3'UTR	NM_031885	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein	399					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1						AATTCTGTATGAGCAGTTTGG	0.473									Bardet-Biedl_syndrome				36	127					0	0	0	0	C	56535295	C	C	56535295	3	2	261	1	0	0	0	0	1	0	0	0	1340	1290	45	2	1002	2	BBS2	16	56535295	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	42816	56535295	33819458	376	47752											
TEPP	374739	broad.mit.edu	37	chr16	58019836	58019836	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cactttccgaagcttcggctCcagctacaggtaggggaacg	9	8	12	12	3	0	0	0	0	0	0	3	2	2	1	2	4	4	4	2	4	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:58019836C>G	uc002emw.3	+	7	813	c.776C>G	c.(775-777)TCC>TGC	p.S259C	TEPP_uc002emv.3_Missense_Mutation_p.S286C	NM_199456	NP_955535	Q6URK8	TEPP_HUMAN	testis/prostate/placenta-expressed protein	259						extracellular region				kidney(1)|central_nervous_system(1)|skin(1)	3						AGCTTCGGCTCCAGCTACAGG	0.652													8	46					0	0	0	0	G	58019836	G	G	58019836	3	3	261	1	0	0	0	0	1	0	0	0	15826	855	30	2	883	2	TEPP	16	58019836	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1484541	58019836	32334917	377	47753											
CCDC113	29070	broad.mit.edu	37	chr16	58296295	58296295	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttctgagctgtagaaggaaGaggtgagtgaggcccttcac	10	10	14	7	0	2	5	1	3	1	2	2	6	2	6	1	3	1	2	1	3	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:58296295G>C	uc002ene.2	+	6	713	c.634G>C	c.(634-636)GAG>CAG	p.E212Q	CCDC113_uc010vid.1_Missense_Mutation_p.E158Q	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	212	Potential.					protein complex					0						GTAGAAGGAAGAGGTGAGTGA	0.418													29	94					0	0	0	0	C	58296295	C	C	58296295	3	2	261	1	0	0	0	0	1	0	0	0	2762	943	33	2	656	2	CCDC113	16	58296295	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	276459	58296295	32058458	378	47754											
GOT2	2806	broad.mit.edu	37	chr16	58757719	58757719	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaccaactcccagattcatCtttttgctattggtgtccct	7	15	6	13	0	2	1	1	0	1	1	4	1	4	1	3	1	2	2	3	1	2	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:58757719C>G	uc002eof.1	-	2	291	c.177G>C	c.(175-177)AAG>AAC	p.K59N	GOT2_uc010vim.1_Missense_Mutation_p.K59N	NM_002080	NP_002071	P00505	AATM_HUMAN	aspartate aminotransferase 2 precursor	59					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCAGATTCATCTTTTTGCTAT	0.493													41	137					0	0	0	0	G	58757719	G	G	58757719	3	3	261	1	0	0	0	0	1	0	0	0	6618	912	32	2	1151	2	GOT2	16	58757719	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	461424	58757719	31597034	379	47755											
LRRC36	55282	broad.mit.edu	37	chr16	67405069	67405069	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcactaagcccatcgaagaGaggattcaaatggaaggaca	16	6	11	8	1	2	1	2	0	0	1	3	6	2	4	1	3	1	0	1	3	4	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:67405069G>C	uc002esv.2	+	9	1437	c.1418G>C	c.(1417-1419)AGA>ACA	p.R473T	LRRC36_uc002esw.2_RNA|LRRC36_uc010ceh.2_Missense_Mutation_p.R205T|LRRC36_uc002esx.2_Missense_Mutation_p.R352T|LRRC36_uc010vjk.1_Missense_Mutation_p.R352T|LRRC36_uc010vjl.1_5'UTR|LRRC36_uc002esy.2_Intron	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	473											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		CCATCGAAGAGAGGATTCAAA	0.468													23	90					0	0	0	0	C	67405069	C	C	67405069	3	2	261	1	0	0	0	0	1	0	0	0	9040	942	33	2	1480	2	LRRC36	16	67405069	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	8647350	67405069	22949684	380	47756											
FAM65A	79567	broad.mit.edu	37	chr16	67573997	67573997	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tactgtgtccagcggcgtctCcgggatggtgcctacaacat	7	10	12	12	3	1	0	0	0	1	0	3	1	2	1	3	3	5	0	3	3	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:67573997C>T	uc010vjp.1	+	7	612	c.516C>T	c.(514-516)CTC>CTT	p.L172L	FAM65A_uc010cei.1_5'UTR|FAM65A_uc002eth.2_Silent_p.L152L|FAM65A_uc010cej.2_Silent_p.L155L|FAM65A_uc002eti.1_Silent_p.L115L|FAM65A_uc010vjq.1_Silent_p.L166L|FAM65A_uc002etj.1_Silent_p.L151L|FAM65A_uc002etk.2_Silent_p.L151L	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	156						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		AGCGGCGTCTCCGGGATGGTG	0.637													30	72					0	0	0	0	T	67573997	T	T	67573997	2	4	261	1	0	0	0	0	0	0	0	1	5631	842	30	2		2	FAM65A	16	67573997	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	168928	67573997	22780756	381	47757											
HAS3	3038	broad.mit.edu	37	chr16	69148496	69148496	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtcctgagccttggctaccGaactaagtataccgcgcgct	9	9	10	13	4	0	1	0	1	0	0	1	2	1	1	4	1	4	3	4	1	5	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:69148496G>A	uc010cfh.2	+	4	1213	c.989G>A	c.(988-990)CGA>CAA	p.R330Q	HAS3_uc002ewk.2_Intron|HAS3_uc002ewl.2_Missense_Mutation_p.R330Q	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	330	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		CTTGGCTACCGAACTAAGTAT	0.582													16	40					0	0	0	0	A	69148496	A	A	69148496	3	1	261	1	0	0	0	0	1	0	0	0	7002	1058	37	1	999	1	HAS3	16	69148496	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1574499	69148496	21206257	382	47758											
COG4	25839	broad.mit.edu	37	chr16	70553601	70553601	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttcaatggtgttttgctgttCcaaaagagcatccagctctc	9	14	8	10	0	2	1	1	0	1	1	5	1	4	1	2	1	3	5	2	1	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:70553601C>G	uc002ezc.2	-	2	216	c.205G>C	c.(205-207)GAA>CAA	p.E69Q	COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.E69Q|COG4_uc002eze.2_Intron	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	65	Interacts with SCFD1.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				TTTTGCTGTTCCAAAAGAGCA	0.378													4	24					0	0	0	0	G	70553601	G	G	70553601	3	3	261	1	0	0	0	0	1	0	0	0	3675	864	30	2	2236	2	COG4	16	70553601	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1405105	70553601	19801152	383	47759											
ZCCHC14	23174	broad.mit.edu	37	chr16	87451158	87451158	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccattctgctcctgggtctGaggggtctgcagactggaag	6	10	14	11	0	3	2	0	1	3	1	4	3	4	3	2	4	2	2	2	4	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:87451158G>C	uc002fjz.1	-	8	907	c.880C>G	c.(880-882)CAG>GAG	p.Q294E	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.Q70E	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	294					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		TCCTGGGTCTGAGGGGTCTGC	0.572													46	132					0	0	0	0	C	87451158	C	C	87451158	3	2	261	1	0	0	0	0	1	0	0	0	17650	1299	45	2	1993	2	ZCCHC14	16	87451158	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	16897557	87451158	2903595	384	47760											
CPNE7	27132	broad.mit.edu	37	chr16	89655212	89655212	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgagatctgccaggactatGacaggtgcgcccaccacctt	9	7	11	14	2	1	2	0	1	1	1	1	4	1	3	4	2	2	0	4	2	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:89655212G>A	uc002fnp.2	+	12	1412	c.1282G>A	c.(1282-1284)GAC>AAC	p.D428N	CPNE7_uc002fnq.2_Missense_Mutation_p.D353N	NM_014427	NP_055242	Q9UBL6	CPNE7_HUMAN	copine 7 isoform b	428	VWFA.				lipid metabolic process		transporter activity				0		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		CCAGGACTATGACAGGTGCGC	0.642													13	26					0	0	0	0	A	89655212	A	A	89655212	3	1	261	1	0	0	0	0	1	0	0	0	3832	1290	45	2	1328	2	CPNE7	16	89655212	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2204054	89655212	699541	385	47761											
VPS53	55275	broad.mit.edu	37	chr17	455171	455171	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagatcctgaaccagcagctGaatactgctggagatgacgc	12	7	11	11	1	0	5	0	3	0	2	1	6	1	5	2	1	5	3	2	1	3	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:455171G>A	uc002frn.2	-	17	1954	c.1807C>T	c.(1807-1809)CAG>TAG	p.Q603*	VPS53_uc002frk.2_Nonsense_Mutation_p.Q122*|VPS53_uc010cjo.1_Nonsense_Mutation_p.Q603*|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Nonsense_Mutation_p.Q574*|VPS53_uc002fro.2_Nonsense_Mutation_p.Q405*|VPS53_uc010cjp.1_Nonsense_Mutation_p.Q326*	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	603					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		ACCAGCAGCTGAATACTGCTG	0.502													5	9					0	0	0	0	A	455171	A	A	455171	4	1	261	1	0	0	0	0	0	1	0	0	17283	1299	45	2	730	2	VPS53	17	455171	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08		455171	80740039	386	47762											
GEMIN4	50628	broad.mit.edu	37	chr17	649539	649539	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagggcagggaaggcagtgaGaatctgggccaggaacttgt	12	6	17	6	0	1	1	0	1	1	1	1	4	1	3	1	5	1	2	1	5	4	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:649539G>C	uc002frs.1	-	2	1863	c.1744C>G	c.(1744-1746)CTC>GTC	p.L582V		NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	582					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		AAGGCAGTGAGAATCTGGGCC	0.547													16	41					0	0	0	0	C	649539	C	C	649539	3	2	261	1	0	0	0	0	1	0	0	0	6367	942	33	2	1436	2	GEMIN4	17	649539	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	194368	649539	80545671	387	47763											
RAP1GAP2	23108	broad.mit.edu	37	chr17	2930332	2930332	+	Frame_Shift_Del	DEL	C	-	-																															ccccagcctgggggcagctgCcaccccgatcatcatgagcc																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:2930332delC	uc010ckd.2	+	22	2165	c.2075delC	c.(2074-2076)GCCfs	p.A692fs	RAP1GAP2_uc010cke.2_Frame_Shift_Del_p.A677fs	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	692	Ser-rich.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						GGGGCAGCTGCCACCCCGATC	0.647													---	---	---								-	2930332	-	-	2930332	7	5	261	1	0	1	0	1	0	0	0	0	13103	739	26	0	2161	0	RAP1GAP2	17	2930332	Frame_Shift_Del	DEL	C	TCGA-CV-7427-01A-11D-2078-08	2280793	2930332	78264878	388	47764											
OR1A1	8383	broad.mit.edu	37	chr17	3119610	3119610	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggttccttccaccaagggCgtgctcaaggccttctccac	7	9	9	16	1	2	0	1	0	1	0	5	0	4	0	5	3	1	2	5	3	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:3119610C>T	uc010vrc.1	+	1	696	c.696C>T	c.(694-696)GGC>GGT	p.G232G		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCACCAAGGGCGTGCTCAAGG	0.483													35	108					0	0	0	0	T	3119610	T	T	3119610	2	4	261	1	0	0	0	0	0	0	0	1	11003	755	27	1		1	OR1A1	17	3119610	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	189278	3119610	78075600	389	47765											
YBX2	51087	broad.mit.edu	37	chr17	7192869	7192869	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaggggctgcgggctgccGggggccaggggcctgctggg	2	5	22	12	2	1	0	1	0	0	0	1	0	1	0	3	8	3	3	3	8	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:7192869G>A	uc002gfq.2	-	7	1081	c.1024C>T	c.(1024-1026)CGG>TGG	p.R342W		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	342	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						GCGGGCTGCCGGGGGCCAGGG	0.667													6	11					0	0	0	0	A	7192869	A	A	7192869	3	1	261	1	0	0	0	0	1	0	0	0	17538	1115	39	1	78	1	YBX2	17	7192869	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4073259	7192869	74002341	390	47766											
NEURL4	84461	broad.mit.edu	37	chr17	7228995	7228995	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taatgaagaagtgtagggcaGagttggacttccttgtgagg	11	11	15	4	0	0	4	0	2	0	2	1	5	1	5	1	3	0	3	1	3	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:7228995G>C	uc002gga.1	-	7	1338	c.1331C>G	c.(1330-1332)TCT>TGT	p.S444C	NEURL4_uc002ggb.1_Missense_Mutation_p.S444C|NEURL4_uc002ggc.1_5'UTR	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	444	NHR 2.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GTGTAGGGCAGAGTTGGACTT	0.567													25	86					0	0	0	0	C	7228995	C	C	7228995	3	2	261	1	0	0	0	0	1	0	0	0	10401	942	33	2	3449	2	NEURL4	17	7228995	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	36126	7228995	73966215	391	47767											
FXR2	9513	broad.mit.edu	37	chr17	7496331	7496331	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tagatgaagaattgtatctcGaagtgggccggggggcaggt	10	9	17	5	2	1	3	0	1	1	2	2	4	1	3	1	5	0	2	1	5	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:7496331G>A	uc002gia.1	-	13	1726	c.1499C>T	c.(1498-1500)TCG>TTG	p.S500L	SOX15_uc002ghy.1_5'Flank|SOX15_uc002ghz.1_5'Flank	NM_004860	NP_004851	P51116	FXR2_HUMAN	fragile X mental retardation syndrome related	500						cytosolic large ribosomal subunit	protein binding|RNA binding				0				READ - Rectum adenocarcinoma(115;0.17)		ATTGTATCTCGAAGTGGGCCG	0.617													10	44					0	0	0	0	A	7496331	A	A	7496331	3	1	261	1	0	0	0	0	1	0	0	0	6150	1059	37	1	442	1	FXR2	17	7496331	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	267336	7496331	73698879	392	47768											
KDM6B	23135	broad.mit.edu	37	chr17	7752247	7752247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caggcgggccctgggcccggGagcgcagggcgggcgaagag	6	1	22	12	5	0	1	0	0	0	1	0	3	0	2	2	6	1	1	2	6	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:7752247G>A	uc002giw.1	+	11	3017	c.2641G>A	c.(2641-2643)GAG>AAG	p.E881K	KDM6B_uc002gix.2_Missense_Mutation_p.E183K	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	881	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CTGGGCCCGGGAGCGCAGGGC	0.716													4	11					0	0	0	0	A	7752247	A	A	7752247	3	1	261	1	0	0	0	0	1	0	0	0	8177	1175	41	2	2671	2	KDM6B	17	7752247	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	255916	7752247	73442963	393	47769											
KDM6B	23135	broad.mit.edu	37	chr17	7753196	7753196	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttcccctgcccagtctgtGaaaccgaagatcaacactga	11	9	7	14	1	2	3	1	2	1	1	3	4	3	3	4	0	3	0	4	0	3	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:7753196G>A	uc002giw.1	+	12	3874	c.3498G>A	c.(3496-3498)GTG>GTA	p.V1166V	KDM6B_uc002gix.2_Silent_p.V468V	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1166					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCCAGTCTGTGAAACCGAAGA	0.532													40	120					0	0	0	0	A	7753196	A	A	7753196	2	1	261	1	0	0	0	0	0	0	0	1	8177	1277	45	2		2	KDM6B	17	7753196	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	949	7753196	73442014	394	47770											
NCOR1	9611	broad.mit.edu	37	chr17	15942786	15942786	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccttcctctcttcgtgtctCaccactggtcacaactgagg	6	12	7	16	1	3	1	2	1	2	0	7	1	4	1	3	2	1	0	3	2	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:15942786C>T	uc002gpo.2	-	44	7156	c.6916G>A	c.(6916-6918)GAG>AAG	p.E2306K	NCOR1_uc002gpn.2_Missense_Mutation_p.E2203K|NCOR1_uc002gpl.2_Missense_Mutation_p.E321K|NCOR1_uc002gpm.2_Missense_Mutation_p.E826K|NCOR1_uc010vwb.1_Missense_Mutation_p.E890K|NCOR1_uc010coy.2_Missense_Mutation_p.E1214K	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2306	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTTCGTGTCTCACCACTGGTC	0.483													7	36					0	0	0	0	T	15942786	T	T	15942786	3	4	261	1	0	0	0	0	1	0	0	0	10289	835	29	2	418	2	NCOR1	17	15942786	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	8189590	15942786	65252424	395	47771											
NCOR1	9611	broad.mit.edu	37	chr17	16029434	16029434	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttttcctcttcatctttCttttcttcttcttttttttc	1	29	0	11	0	8	0	1	0	7	0	10	0	9	0	1	0	0	0	1	0	0	12			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:16029434C>G	uc002gpo.2	-	15	1836	c.1596G>C	c.(1594-1596)AAG>AAC	p.K532N	NCOR1_uc002gpn.2_Missense_Mutation_p.K532N|NCOR1_uc002gpp.1_Missense_Mutation_p.K423N|NCOR1_uc002gpr.2_Missense_Mutation_p.K423N|NCOR1_uc002gps.1_Missense_Mutation_p.K541N|NCOR1_uc010coz.1_Missense_Mutation_p.K348N|NCOR1_uc010cpb.1_Missense_Mutation_p.K542N|NCOR1_uc010cpa.1_Missense_Mutation_p.K533N	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	532	Potential.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		cttcatctttcttttcttctt	0.114													3	7					0	0	0	0	G	16029434	G	G	16029434	3	3	261	1	0	0	0	0	1	0	0	0	10289	912	32	2	5854	2	NCOR1	17	16029434	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	86648	16029434	65165776	396	47772											
SREBF1	6720	broad.mit.edu	37	chr17	17719301	17719301	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaggaggcactgagccactCtgtgccaggcaggcctggcg	7	5	16	13	1	1	1	0	1	1	0	1	2	1	2	3	5	2	3	3	5	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:17719301C>G	uc002gru.1	-	12	2450	c.2256G>C	c.(2254-2256)CAG>CAC	p.Q752H	SREBF1_uc002grp.1_Missense_Mutation_p.Q371H|SREBF1_uc002grq.1_Missense_Mutation_p.Q271H|SREBF1_uc002grr.1_Missense_Mutation_p.Q498H|SREBF1_uc002grs.1_Missense_Mutation_p.Q728H|SREBF1_uc002grt.1_Missense_Mutation_p.Q782H|MIR33B_hsa-mir-33b|MI0003646_5'Flank	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	752	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						CTGAGCCACTCTGTGCCAGGC	0.667													5	43					0	0	0	0	G	17719301	G	G	17719301	3	3	261	1	0	0	0	0	1	0	0	0	15207	912	32	2	1219	2	SREBF1	17	17719301	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1689867	17719301	63475909	397	47773											
SMCR8	140775	broad.mit.edu	37	chr17	18220060	18220060	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtgttttgacaagaagttGaagaccttggaggagctctg	12	11	13	5	0	1	4	0	2	1	2	1	6	1	6	1	2	1	3	1	2	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:18220060G>A	uc002gsy.3	+	1	1467	c.957G>A	c.(955-957)TTG>TTA	p.L319L		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	319										central_nervous_system(1)	1						ACAAGAAGTTGAAGACCTTGG	0.493													18	55					0	0	0	0	A	18220060	A	A	18220060	2	1	261	1	0	0	0	0	0	0	0	1	14856	1281	45	2		2	SMCR8	17	18220060	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	500759	18220060	62975150	398	47774											
NOS2	4843	broad.mit.edu	37	chr17	26114730	26114730	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggagccgtaatattggttGacaaattcgatagcttgagg	13	11	12	5	2	0	2	0	2	0	0	1	4	0	3	1	3	2	3	1	3	5	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:26114730G>A	uc002gzu.2	-	5	705	c.441C>T	c.(439-441)GTC>GTT	p.V147V	NOS2_uc010crh.1_Silent_p.V147V|NOS2_uc010wab.1_Silent_p.V147V	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	147					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AATATTGGTTGACAAATTCGA	0.537													23	82					0	0	0	0	A	26114730	A	A	26114730	2	1	261	1	0	0	0	0	0	0	0	1	10597	1277	45	2		2	NOS2	17	26114730	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	7894670	26114730	55080480	399	47775											
SGK494	124923	broad.mit.edu	37	chr17	26940613	26940613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atagtggtgcccccgtagttCccagagttcttccagatctg	7	12	10	12	1	2	2	0	0	2	2	4	2	4	2	4	1	1	3	4	1	2	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:26940613C>T	uc002hbr.1	-	2	201	c.169G>A	c.(169-171)GAA>AAA	p.E57K	SGK494_uc010waq.1_Missense_Mutation_p.E57K|SGK494_uc010war.1_RNA|uc010crq.1_5'Flank|uc002hbs.1_Intron	NM_144610	NP_653211			uncharacterized serine/threonine-protein kinase												0						CCCCGTAGTTCCCAGAGTTCT	0.582											OREG0024279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	81					0	0	0	0	T	26940613	T	T	26940613	3	4	261	1	0	0	0	0	1	0	0	0	14278	864	30	2	1107	2	SGK494	17	26940613	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	825883	26940613	54254597	400	47776											
CCDC55	84081	broad.mit.edu	37	chr17	28506198	28506198	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaaatacagagagaacgaGaaatggaaaagggggagttt	20	5	14	2	1	0	4	0	0	0	4	0	8	0	6	0	3	2	1	0	3	7	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:28506198G>C	uc002heu.2	+	5	419	c.391G>C	c.(391-393)GAA>CAA	p.E131Q	CCDC55_uc002hev.2_Missense_Mutation_p.E77Q|CCDC55_uc010wbl.1_Missense_Mutation_p.E77Q|CCDC55_uc010wbm.1_Missense_Mutation_p.E77Q|CCDC55_uc002hex.2_Missense_Mutation_p.E77Q	NM_032141	NP_115517	Q9H0G5	NSRP1_HUMAN	coiled-coil domain containing 55 isoform 1	131	Necessary for alternative splicing activity.|Potential.				developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding				0						GAGAGAACGAGAAATGGAAAA	0.353													5	19					0	0	0	0	C	28506198	C	C	28506198	3	2	261	1	0	0	0	0	1	0	0	0	2838	943	33	2	409	2	CCDC55	17	28506198	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1565585	28506198	52689012	401	47777											
GGNBP2	79893	broad.mit.edu	37	chr17	34937844	34937844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaattttcagaagaggaacGagtaagagaactcaagcaag	18	6	12	5	1	2	3	2	0	0	3	2	7	2	5	0	2	3	2	0	2	7	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:34937844G>A	uc002hnb.2	+	9	1340	c.1091G>A	c.(1090-1092)CGA>CAA	p.R364Q	GGNBP2_uc002hna.2_Missense_Mutation_p.R364Q|GGNBP2_uc002hnc.1_Missense_Mutation_p.R193Q	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	364					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GAAGAGGAACGAGTAAGAGAA	0.368													29	60					0	0	0	0	A	34937844	A	A	34937844	3	1	261	1	0	0	0	0	1	0	0	0	6396	1058	37	1	1121	1	GGNBP2	17	34937844	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	6431646	34937844	46257366	402	47778											
CDC6	990	broad.mit.edu	37	chr17	38450695	38450695	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgtaagccacagctgttGaacttcccaccttataccag	13	10	6	12	0	0	1	0	1	0	0	1	1	1	1	4	0	4	3	4	0	5	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:38450695G>C	uc002huj.1	+	7	1233	c.1023G>C	c.(1021-1023)TTG>TTC	p.L341F		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	341					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						CACAGCTGTTGAACTTCCCAC	0.398													20	70					0	0	0	0	C	38450695	C	C	38450695	3	2	261	1	0	0	0	0	1	0	0	0	3098	1281	45	2	1045	2	CDC6	17	38450695	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3512851	38450695	42744515	403	47779											
KRT10	3858	broad.mit.edu	37	chr17	38978336	38978336	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagctcatagtttgattcttCcagagcccgaactttgtcca	9	13	7	12	1	2	2	1	1	1	1	4	3	4	2	3	0	3	2	3	0	2	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:38978336C>A	uc002hvi.2	-	1	528	c.502G>T	c.(502-504)GAA>TAA	p.E168*	KRT10_uc010cxd.2_5'Flank|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	168	Coil 1A.|Rod.|Gly-rich.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				TTTGATTCTTCCAGAGCCCGA	0.438													32	109					1.55811e-20	1.69262e-20	1	0	A	38978336	A	A	38978336	4	1	261	1	0	0	0	0	0	1	0	0	8487	864	30	2	1284	2	KRT10	17	38978336	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	527641	38978336	42216874	404	47780											
FKBP10	60681	broad.mit.edu	37	chr17	39975508	39975508	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtctttcacgtcctcctGattgacgtgcacaacccgaa	8	11	8	14	3	2	2	1	2	1	0	4	3	4	2	3	1	2	1	3	1	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:39975508G>C	uc002hxv.2	+	5	1099	c.774G>C	c.(772-774)CTG>CTC	p.L258L	FKBP10_uc002hxw.1_5'UTR	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	258	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		ACGTCCTCCTGATTGACGTGC	0.632													27	73					0	0	0	0	C	39975508	C	C	39975508	2	2	261	1	0	0	0	0	0	0	0	1	5934	1277	45	2		2	FKBP10	17	39975508	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	997172	39975508	41219702	405	47781											
KCNH4	23415	broad.mit.edu	37	chr17	40318431	40318431	+	Missense_Mutation	SNP	G	A	A																															actcgcccggagcgcagaacGaggtcttgatgtgcagcgat																								rs140560707		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:40318431G>A	uc002hzb.2	-	10	2057	c.1724C>T	c.(1723-1725)TCG>TTG	p.S575L		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	575	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGCGCAGAACGAGGTCTTGAT	0.622													4	24					0	0	0	0	A	40318431	A	A	40318431	3	1	261	1	0	0	0	0	1	0	0	0	8073	1059	37	1	1357	1	KCNH4	17	40318431	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	342923	40318431	40876779	406	47782	104	2									
KCNH4	23415	broad.mit.edu	37	chr17	40318439	40318439	+	Missense_Mutation	SNP	G	C	C																															ggagcgcagaacgaggtcttGatgtgcagcgatagggcccg																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:40318439G>C	uc002hzb.2	-	10	2049	c.1716C>G	c.(1714-1716)ATC>ATG	p.I572M		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	572	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ACGAGGTCTTGATGTGCAGCG	0.627													5	21					0	0	0	0	C	40318439	C	C	40318439	3	2	261	1	0	0	0	0	1	0	0	0	8073	1280	45	2	1365	2	KCNH4	17	40318439	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	8	40318439	40876771	407	47783	104	2									
STAT5B	6777	broad.mit.edu	37	chr17	40362425	40362425	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaataatgattctcacccatCattccaatgaggcttgagat	14	12	6	9	0	2	3	2	3	1	1	4	4	3	3	2	1	0	1	2	1	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:40362425C>T	uc002hzh.2	-	14	1940	c.1771G>A	c.(1771-1773)GAT>AAT	p.D591N		NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	591	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	TCTCACCCATCATTCCAATGA	0.448													19	87					0	0	0	0	T	40362425	T	T	40362425	3	4	261	1	0	0	0	0	1	0	0	0	15335	826	29	2	616	2	STAT5B	17	40362425	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	43986	40362425	40832785	408	47784											
CNTNAP1	8506	broad.mit.edu	37	chr17	40843231	40843231	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggaggctcccagcctgggatCcagcgctgtgcctgtggtct	4	9	15	13	1	1	0	0	0	1	0	3	2	3	2	4	4	3	2	4	4	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:40843231C>G	uc002iay.2	+	14	2352	c.2136C>G	c.(2134-2136)ATC>ATG	p.I712M	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	712	Extracellular (Potential).|Fibrinogen C-terminal.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		AGCCTGGGATCCAGCGCTGTG	0.617													13	95					0	0	0	0	G	40843231	G	G	40843231	3	3	261	1	0	0	0	0	1	0	0	0	3661	845	30	2	2190	2	CNTNAP1	17	40843231	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	480806	40843231	40351979	409	47785											
ADAM11	4185	broad.mit.edu	37	chr17	42855094	42855094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagctggcggacggctctGacctgagctatgtggaggat	7	9	16	9	2	1	2	0	2	1	0	1	5	1	5	1	5	3	4	1	5	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:42855094G>A	uc002ihh.2	+	23	1933	c.1933G>A	c.(1933-1935)GAC>AAC	p.D645N	ADAM11_uc010wjd.1_Missense_Mutation_p.D445N|ADAM11_uc002ihi.2_5'UTR	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	645	Cys-rich.|Extracellular (Potential).				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GGACGGCTCTGACCTGAGCTA	0.642													9	31					0	0	0	0	A	42855094	A	A	42855094	3	1	261	1	0	0	0	0	1	0	0	0	235	1290	45	2	2023	2	ADAM11	17	42855094	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2011863	42855094	38340116	410	47786											
NMT1	4836	broad.mit.edu	37	chr17	43159088	43159088	+	Missense_Mutation	SNP	G	A	A																															agaagaaagaaaaaggcagtGagacagattcagcccaggat																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:43159088G>A	uc002ihz.2	+	2	226	c.208G>A	c.(208-210)GAG>AAG	p.E70K	NMT1_uc010dac.1_Intron|NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	70					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				aaaaGGCAGTGAGACAGATTC	0.348													7	8					0	0	0	0	A	43159088	A	A	43159088	3	1	261	1	0	0	0	0	1	0	0	0	10557	1291	45	2	214	2	NMT1	17	43159088	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	303994	43159088	38036122	411	47787	105	2									
NMT1	4836	broad.mit.edu	37	chr17	43159090	43159090	+	Silent	SNP	G	A	A																															aagaaagaaaaaggcagtgaGacagattcagcccaggatca																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:43159090G>A	uc002ihz.2	+	2	228	c.210G>A	c.(208-210)GAG>GAA	p.E70E	NMT1_uc010dac.1_Intron|NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	70					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				aaGGCAGTGAGACAGATTCAG	0.348													5	7					0	0	0	0	A	43159090	A	A	43159090	2	1	261	1	0	0	0	0	0	0	0	1	10557	933	33	2		2	NMT1	17	43159090	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2	43159090	38036120	412	47788	105	2									
MAP3K14	9020	broad.mit.edu	37	chr17	43364681	43364681	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacgggccattttgccctCtgtagcatgggccacattgt	7	11	10	13	1	1	0	0	0	1	0	1	0	1	0	3	2	2	2	3	2	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:43364681C>A	uc002iiw.1	-	4	485	c.376G>T	c.(376-378)GAG>TAG	p.E126*	MAP3K14_uc010daj.1_5'Flank|MAP3K14_uc002iiv.1_5'UTR	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	126					cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						ATTTTGCCCTCTGTAGCATGG	0.493													7	31					0.000157383	0.000163614	1	0	A	43364681	A	A	43364681	4	1	261	1	0	0	0	0	0	1	0	0	9301	922	32	2	2518	2	MAP3K14	17	43364681	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	205591	43364681	37830529	413	47789											
CALCOCO2	10241	broad.mit.edu	37	chr17	46926688	46926688	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgaaggacagctgtatCagcctccagaagcagaactc	13	6	11	11	0	1	3	1	1	0	2	3	5	2	4	2	1	5	4	2	1	4	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:46926688C>A	uc002iof.2	+	5	571	c.492C>A	c.(490-492)ATC>ATA	p.I164I	CALCOCO2_uc010wlp.1_Silent_p.I185I|CALCOCO2_uc010wlq.1_Silent_p.I92I|CALCOCO2_uc010wlr.1_Silent_p.I188I|CALCOCO2_uc010wls.1_Intron	NM_005831	NP_005822	Q13137	CACO2_HUMAN	calcium binding and coiled-coil domain 2	164	Potential.				response to interferon-gamma|viral reproduction	cytoskeleton|Golgi apparatus|nucleus|perinuclear region of cytoplasm|soluble fraction	protein homodimerization activity			ovary(1)	1						ACAGCTGTATCAGCCTCCAGA	0.473													32	72					2.68265e-12	2.87801e-12	1	0	A	46926688	A	A	46926688	2	1	261	1	0	0	0	0	0	0	0	1	2590	816	29	2		2	CALCOCO2	17	46926688	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3562007	46926688	34268522	414	47790											
ZNF652	22834	broad.mit.edu	37	chr17	47388699	47388699	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgttttcatgtgttcgtcGaagtactgcttcatgttgaa	7	18	10	6	2	2	1	2	1	0	0	4	2	2	1	0	0	2	5	0	0	3	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:47388699G>A	uc002iov.3	-	5	1748	c.1284C>T	c.(1282-1284)TTC>TTT	p.F428F	ZNF652_uc002iow.2_Silent_p.F428F|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	428	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			TGTGTTCGTCGAAGTACTGCT	0.423													24	79					0	0	0	0	A	47388699	A	A	47388699	2	1	261	1	0	0	0	0	0	0	0	1	18132	1049	37	1		1	ZNF652	17	47388699	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	462011	47388699	33806511	415	47791											
CACNA1G	8913	broad.mit.edu	37	chr17	48646576	48646576	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccgtggagatggtggtgaaGatggtggccttgggcatctt	6	11	18	6	1	1	3	0	1	1	2	1	4	1	3	2	6	0	1	2	6	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:48646576G>C	uc002irk.1	+	3	777	c.405G>C	c.(403-405)AAG>AAC	p.K135N	CACNA1G_uc002iri.1_Missense_Mutation_p.K135N|CACNA1G_uc002irj.1_Missense_Mutation_p.K135N|CACNA1G_uc002irl.1_Missense_Mutation_p.K135N|CACNA1G_uc002irm.1_Missense_Mutation_p.K135N|CACNA1G_uc002irn.1_Missense_Mutation_p.K135N|CACNA1G_uc002iro.1_Missense_Mutation_p.K135N|CACNA1G_uc002irp.1_Missense_Mutation_p.K135N|CACNA1G_uc002irq.1_Missense_Mutation_p.K135N|CACNA1G_uc002irr.1_Missense_Mutation_p.K135N|CACNA1G_uc002irs.1_Missense_Mutation_p.K135N|CACNA1G_uc002irt.1_Missense_Mutation_p.K135N|CACNA1G_uc002irv.1_Missense_Mutation_p.K135N|CACNA1G_uc002irw.1_Missense_Mutation_p.K135N|CACNA1G_uc002iru.1_Missense_Mutation_p.K135N|CACNA1G_uc002irx.1_Missense_Mutation_p.K48N|CACNA1G_uc002iry.1_Missense_Mutation_p.K48N|CACNA1G_uc002irz.1_Missense_Mutation_p.K48N|CACNA1G_uc002isa.1_Missense_Mutation_p.K48N|CACNA1G_uc002isb.1_Missense_Mutation_p.K48N|CACNA1G_uc002isc.1_Missense_Mutation_p.K48N|CACNA1G_uc002isd.1_Missense_Mutation_p.K48N|CACNA1G_uc002ise.1_Missense_Mutation_p.K48N|CACNA1G_uc002isf.1_Missense_Mutation_p.K48N|CACNA1G_uc002isg.1_Missense_Mutation_p.K48N|CACNA1G_uc002ish.1_Missense_Mutation_p.K48N|CACNA1G_uc002isi.1_Missense_Mutation_p.K48N	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	135	Helical; Name=S2 of repeat I; (Potential).|I.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TGGTGGTGAAGATGGTGGCCT	0.527													9	32					0	0	0	0	C	48646576	C	C	48646576	3	2	261	1	0	0	0	0	1	0	0	0	2556	933	33	2	415	2	CACNA1G	17	48646576	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1257877	48646576	32548634	416	47792											
TUBD1	51174	broad.mit.edu	37	chr17	57963531	57963531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccagactgggcagcctttGacagcatttgattgataact	10	11	11	9	0	0	4	0	3	0	1	0	4	0	4	2	2	3	2	2	2	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:57963531G>A	uc002ixw.1	-	3	511	c.233C>T	c.(232-234)TCA>TTA	p.S78L	TUBD1_uc010ddf.1_Missense_Mutation_p.S78L|TUBD1_uc010ddg.1_Missense_Mutation_p.S43L|TUBD1_uc010ddh.1_5'UTR|TUBD1_uc010wok.1_Missense_Mutation_p.S78L|TUBD1_uc002ixx.1_Missense_Mutation_p.S78L|TUBD1_uc010wol.1_Intron|TUBD1_uc010ddi.1_Intron	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	78					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			GGCAGCCTTTGACAGCATTTG	0.413													6	75					0	0	0	0	A	57963531	A	A	57963531	3	1	261	1	0	0	0	0	1	0	0	0	16830	1294	45	2	1156	2	TUBD1	17	57963531	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	9316955	57963531	23231679	417	47793											
USP32	84669	broad.mit.edu	37	chr17	58288742	58288742	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccagaaagattacctgttGagttcataaagatgtctccc	12	12	7	10	0	2	4	1	1	1	3	4	4	3	4	3	0	1	2	3	0	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:58288742G>C	uc002iyo.1	-	20	2599	c.2313C>G	c.(2311-2313)CTC>CTG	p.L771L	USP32_uc002iyn.1_Silent_p.L441L	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	771					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ATTACCTGTTGAGTTCATAAA	0.408													8	120					0	0	0	0	C	58288742	C	C	58288742	2	2	261	1	0	0	0	0	0	0	0	1	17131	1277	45	2		2	USP32	17	58288742	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	325211	58288742	22906468	418	47794											
CYB561	1534	broad.mit.edu	37	chr17	61512584	61512584	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagctccggggaacaggaaGaagctgaagcccaccagcca	14	2	13	12	1	0	2	0	1	0	1	1	5	1	4	4	3	5	2	4	3	5	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:61512584G>A	uc002jap.2	-	4	828	c.426C>T	c.(424-426)TTC>TTT	p.F142F	CYB561_uc002jaq.2_Silent_p.F188F|CYB561_uc002jar.2_Silent_p.F142F|CYB561_uc002jas.2_Silent_p.F142F|CYB561_uc010ddt.2_Missense_Mutation_p.S158F|CYB561_uc002jat.2_Silent_p.F142F|CYB561_uc010wpf.1_Intron|CYB561_uc010wpg.1_Silent_p.F113F	NM_001915	NP_001906	P49447	CY561_HUMAN	cytochrome b-561	142	Helical; (Potential).|Cytochrome b561.				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(1115;0.0689)		GGAACAGGAAGAAGCTGAAGC	0.642													11	43					0	0	0	0	A	61512584	A	A	61512584	2	1	261	1	0	0	0	0	0	0	0	1	4136	933	33	2		2	CYB561	17	61512584	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3223842	61512584	19682626	419	47795											
KCNH6	81033	broad.mit.edu	37	chr17	61611639	61611639	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atggtggccgccatccctttCgacctcctgatcttccgcac	5	11	8	17	3	1	1	0	1	1	0	5	2	4	1	6	2	0	1	6	2	0	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:61611639C>T	uc002jay.2	+	5	1148	c.1068C>T	c.(1066-1068)TTC>TTT	p.F356F	KCNH6_uc002jax.1_Silent_p.F356F|KCNH6_uc010wpl.1_Silent_p.F233F|KCNH6_uc010wpm.1_Silent_p.F356F|KCNH6_uc002jaz.1_Silent_p.F356F	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	356	Helical; Name=Segment S3; (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCATCCCTTTCGACCTCCTGA	0.622													15	36					0	0	0	0	T	61611639	T	T	61611639	2	4	261	1	0	0	0	0	0	0	0	1	8075	883	31	1		1	KCNH6	17	61611639	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	99055	61611639	19583571	420	47796											
ABCA9	10350	broad.mit.edu	37	chr17	66972084	66972084	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcctgcaggaggagtttcCacttcaccgagggatcaaag	10	9	11	11	1	2	0	2	0	0	0	4	4	4	3	3	3	1	2	3	3	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:66972084C>T	uc002jhu.2	-	39	4990	c.4847G>A	c.(4846-4848)TGG>TAG	p.W1616*	ABCA9_uc010dez.2_Nonsense_Mutation_p.W1578*	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1616					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					GAGGAGTTTCCACTTCACCGA	0.408													3	12					0	0	0	0	T	66972084	T	T	66972084	4	4	261	1	0	0	0	0	0	1	0	0	39	595	21	4	31	4	ABCA9	17	66972084	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5360445	66972084	14223126	421	47797											
CCDC40	55036	broad.mit.edu	37	chr17	78063659	78063659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagacggagatccgggccatGaagggcgagatccacaggat	12	4	15	10	3	0	4	0	1	0	3	2	7	2	5	3	4	0	0	3	4	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:78063659G>A	uc010dht.2	+	17	2835	c.2808G>A	c.(2806-2808)ATG>ATA	p.M936I	CCDC40_uc002jxm.3_Missense_Mutation_p.M719I|CCDC40_uc002jxn.3_Missense_Mutation_p.M332I	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	936	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TCCGGGCCATGAAGGGCGAGA	0.582													6	29					0	0	0	0	A	78063659	A	A	78063659	3	1	261	1	0	0	0	0	1	0	0	0	2825	1290	45	2	2874	2	CCDC40	17	78063659	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	11091575	78063659	3131551	422	47798											
RNF213	57674	broad.mit.edu	37	chr17	78317686	78317686	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaatttgggtgtttcttttCaagctcctcattttacaata	9	18	7	7	0	3	0	2	0	1	0	4	1	4	1	1	2	2	2	1	2	5	7			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:78317686C>G	uc002jyh.1	+	3	655	c.432C>G	c.(430-432)TTC>TTG	p.F144L		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment								p.F144L(1)		ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGTTTCTTTTCAAGCTCCTCA	0.438													18	89					0	0	0	0	G	78317686	G	G	78317686	3	3	261	1	0	0	0	0	1	0	0	0	13542	825	29	2	6638	2	RNF213	17	78317686	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	254027	78317686	2877524	423	47799											
C17orf90	339229	broad.mit.edu	37	chr17	79632428	79632428	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttgtgggcggctggagctCaggtggcagcgatgccttgg	4	10	19	8	2	1	0	1	0	0	0	1	2	1	1	1	6	3	4	1	6	0	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:79632428C>A	uc002kba.2	-	2	258	c.247G>T	c.(247-249)GAG>TAG	p.E83*	C17orf90_uc002kbb.2_3'UTR|CCDC137_uc002kbc.3_5'Flank|CCDC137_uc002kbd.2_5'Flank	NM_001039842	NP_001034931	Q5BKU9	CQ090_HUMAN	hypothetical protein LOC339229	83											0	all_neural(118;0.0878)|all_lung(278;0.23)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GGCTGGAGCTCAGGTGGCAGC	0.657													8	23					1.76689e-08	1.88552e-08	1	0	A	79632428	A	A	79632428	4	1	261	1	0	0	0	0	0	1	0	0	1899	835	29	2	200	2	C17orf90	17	79632428	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1314742	79632428	1562782	424	47800											
PTPRM	5797	broad.mit.edu	37	chr18	8370921	8370921	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatactggccagatgacacaGagatatataaagacattaaa	20	8	7	6	0	0	4	0	1	0	3	0	5	0	4	1	1	1	0	1	1	8	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:8370921G>C	uc002knn.3	+	22	3552	c.3049G>C	c.(3049-3051)GAG>CAG	p.E1017Q	PTPRM_uc010dkv.2_Missense_Mutation_p.E1030Q|PTPRM_uc010wzl.1_Missense_Mutation_p.E804Q	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1017	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				AGATGACACAGAGATATATAA	0.348													9	74					0	0	0	0	C	8370921	C	C	8370921	3	2	261	1	0	0	0	0	1	0	0	0	12871	943	33	2	3182	2	PTPRM	18	8370921	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08		8370921	69706327	425	47801											
ANKRD12	23253	broad.mit.edu	37	chr18	9256444	9256444	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctaagtcatcaccagcatCaaaagatacccgacctaaag	17	6	5	13	1	3	1	3	0	0	1	3	2	3	1	4	0	2	1	4	0	6	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:9256444C>G	uc002knv.2	+	9	3436	c.3179C>G	c.(3178-3180)TCA>TGA	p.S1060*	ANKRD12_uc002knw.2_Nonsense_Mutation_p.S1037*|ANKRD12_uc002knx.2_Nonsense_Mutation_p.S1037*|ANKRD12_uc010dkx.1_Nonsense_Mutation_p.S767*	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1060						nucleus				ovary(2)|central_nervous_system(1)	3						TCACCAGCATCAAAAGATACC	0.289													24	106					0	0	0	0	G	9256444	G	G	9256444	4	3	261	1	0	0	0	0	0	1	0	0	640	838	29	2	3209	2	ANKRD12	18	9256444	Nonsense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	885523	9256444	68820804	426	47802											
TXNDC2	84203	broad.mit.edu	37	chr18	9887362	9887362	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagaagccatccagcccaagGagggtgacctccccaagtcc	12	4	10	15	0	0	2	0	1	0	1	3	3	3	3	7	2	2	0	7	2	4	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:9887362G>A	uc002koi.3	+	2	1335	c.886G>A	c.(886-888)GAG>AAG	p.E296K	TXNDC2_uc010wzq.1_Intron|TXNDC2_uc002koh.3_Missense_Mutation_p.E229K	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	296	13.|22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						CCAGCCCAAGGAGGGTGACCT	0.602													32	73					0	0	0	0	A	9887362	A	A	9887362	3	1	261	1	0	0	0	0	1	0	0	0	16865	1175	41	2	892	2	TXNDC2	18	9887362	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	630918	9887362	68189886	427	47803											
KIAA1328	57536	broad.mit.edu	37	chr18	34802101	34802101	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtactttccgactcagtcctCtaaaatcaacccggaagaag	13	9	7	12	2	3	1	2	0	1	1	5	3	5	2	3	1	2	1	3	1	6	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:34802101C>G	uc002kzz.2	+	10	1667	c.1645C>G	c.(1645-1647)CTA>GTA	p.L549V	KIAA1328_uc002lab.2_3'UTR|KIAA1328_uc002lac.1_Missense_Mutation_p.L408V|KIAA1328_uc010dnc.1_RNA	NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	549										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		ACTCAGTCCTCTAAAATCAAC	0.473													5	5					0	0	0	0	G	34802101	G	G	34802101	3	3	261	1	0	0	0	0	1	0	0	0	8264	912	32	2	1683	2	KIAA1328	18	34802101	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	24914739	34802101	43275147	428	47804											
TCEB3C	162699	broad.mit.edu	37	chr18	44555035	44555035	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcctggaggcaatgaatcctCcataattcatctgtctctcg	9	13	7	12	1	3	1	1	1	2	0	8	2	6	2	3	2	0	1	3	2	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:44555035C>G	uc010xdb.1	-	1	1415	c.1179G>C	c.(1177-1179)TGG>TGC	p.W393C	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	393	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						AATGAATCCTCCATAATTCAT	0.577													7	221					0	0	0	0	G	44555035	G	G	44555035	3	3	261	1	0	0	0	0	1	0	0	0	15749	856	30	2	2108	2	TCEB3C	18	44555035	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	9752934	44555035	33522213	429	47805											
TCEB3B	51224	broad.mit.edu	37	chr18	44560858	44560858	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggcatccttggggtttcctCtcttaagcaggccccgcatg	5	11	12	13	1	1	0	0	0	1	0	4	0	3	0	4	4	1	4	4	4	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:44560858C>G	uc002lcr.1	-	1	1131	c.778G>C	c.(778-780)GAG>CAG	p.E260Q	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	260					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GGGGTTTCCTCTCTTAAGCAG	0.597													13	57					0	0	0	0	G	44560858	G	G	44560858	3	3	261	1	0	0	0	0	1	0	0	0	15748	922	32	2	1487	2	TCEB3B	18	44560858	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5823	44560858	33516390	430	47806											
ATP8B1	5205	broad.mit.edu	37	chr18	55359051	55359051	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccttacctgacatagagaGagatgggtaccatggtgttg	11	10	13	7	0	0	3	0	1	0	2	0	5	0	3	3	2	3	2	3	2	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:55359051G>C	uc002lgw.2	-	11	1208	c.1208C>G	c.(1207-1209)TCT>TGT	p.S403C	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	403	Helical; (Potential).		S -> Y (in PFIC1).		ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GACATAGAGAGAGATGGGTAC	0.443									Byler_disease				8	37					0	0	0	0	C	55359051	C	C	55359051	3	2	261	1	0	0	0	0	1	0	0	0	1196	942	33	2	2615	2	ATP8B1	18	55359051	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	10798193	55359051	22718197	431	47807											
PHLPP1	23239	broad.mit.edu	37	chr18	60642651	60642651	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaacttggaactgctgggcaGaagcttggtggtgccgctgt	8	10	15	8	1	0	1	0	0	0	1	0	2	0	2	1	4	5	4	1	4	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:60642651G>A	uc002lis.2	+	17	2419	c.2241G>A	c.(2239-2241)CAG>CAA	p.Q747Q		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1259	PP2C-like.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						CTGCTGGGCAGAAGCTTGGTG	0.527													7	84					0	0	0	0	A	60642651	A	A	60642651	2	1	261	1	0	0	0	0	0	0	0	1	11909	933	33	2		2	PHLPP1	18	60642651	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	5283600	60642651	17434597	432	47808											
DOK6	220164	broad.mit.edu	37	chr18	67365819	67365819	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcaacgtggttcacgtttGagtcaggaaggtaagatcta	12	11	11	7	2	4	2	3	1	1	1	4	3	4	3	0	3	1	3	0	3	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:67365819G>C	uc002lkl.2	+	5	779	c.589G>C	c.(589-591)GAG>CAG	p.E197Q		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	197	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GTTCACGTTTGAGTCAGGAAG	0.478													3	17					0	0	0	0	C	67365819	C	C	67365819	3	2	261	1	0	0	0	0	1	0	0	0	4723	1291	45	2	607	2	DOK6	18	67365819	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	6723168	67365819	10711429	433	47809											
DOK6	220164	broad.mit.edu	37	chr18	67406304	67406304	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggccatagctgagcaacatGaaagattaatgctagaaatg	16	9	10	6	0	0	4	0	2	0	2	0	4	0	4	1	1	4	3	1	1	6	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:67406304G>A	uc002lkl.2	+	6	893	c.703G>A	c.(703-705)GAA>AAA	p.E235K		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	235	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TGAGCAACATGAAAGATTAAT	0.448													10	106					0	0	0	0	A	67406304	A	A	67406304	3	1	261	1	0	0	0	0	1	0	0	0	4723	1291	45	2	725	2	DOK6	18	67406304	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	40485	67406304	10670944	434	47810											
CNDP2	55748	broad.mit.edu	37	chr18	72183552	72183552	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggtctggggccaagaccgtGattcccaggaaggtggttgg	7	8	18	8	1	1	2	0	1	1	1	2	3	2	3	3	7	0	1	3	7	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:72183552G>A	uc002llm.1	+	9	1155	c.993G>A	c.(991-993)GTG>GTA	p.V331V	CNDP2_uc002lln.1_Silent_p.V247V|CNDP2_uc010dqs.2_Intron	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	331						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		CCAAGACCGTGATTCCCAGGA	0.597													14	48					0	0	0	0	A	72183552	A	A	72183552	2	1	261	1	0	0	0	0	0	0	0	1	3609	1277	45	2		2	CNDP2	18	72183552	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4777248	72183552	5893696	435	47811											
SBNO2	22904	broad.mit.edu	37	chr19	1109708	1109708	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagaccacctgcccgtcctGcgggtgcccgggagccagga	7	4	15	15	3	0	1	0	0	0	1	1	4	1	3	6	3	4	0	6	3	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:1109708G>A	uc002lrk.3	-	27	3335	c.3097C>T	c.(3097-3099)CAG>TAG	p.Q1033*	SBNO2_uc002lri.3_5'Flank|SBNO2_uc002lrj.3_Nonsense_Mutation_p.Q976*|SBNO2_uc010dse.2_Nonsense_Mutation_p.Q1016*|SBNO2_uc010xgj.1_Intron	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	1033					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCCCGTCCTGCGGGTGCCCG	0.672													10	34					0	0	0	0	A	1109708	A	A	1109708	4	1	261	1	0	0	0	0	0	1	0	0	13928	1328	46	4	1027	4	SBNO2	19	1109708	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08		1109708	58019275	436	47812											
AP3D1	8943	broad.mit.edu	37	chr19	2110821	2110821	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccatgcccttgaggatgctGctgctcctgttctccagcac	5	12	9	15	0	1	1	0	1	1	0	4	2	3	2	4	1	5	5	4	1	0	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:2110821G>A	uc002luz.2	-	25	3097	c.2874C>T	c.(2872-2874)AGC>AGT	p.S958S	AP3D1_uc010dsv.2_Silent_p.S48S|AP3D1_uc002luy.2_Silent_p.S917S|AP3D1_uc002lva.2_Silent_p.S1020S	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	958					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAGGATGCTGCTGCTCCTGT	0.642													8	36					0	0	0	0	A	2110821	A	A	2110821	2	1	261	1	0	0	0	0	0	0	0	1	746	1310	46	4		4	AP3D1	19	2110821	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1001113	2110821	57018162	437	47813											
TLE2	7089	broad.mit.edu	37	chr19	3028341	3028341	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acataatgtcgctgcatttcCgtcttctcgctggccagctt	6	14	8	13	3	2	0	0	0	2	0	5	0	3	0	2	1	2	4	2	1	1	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:3028341C>A	uc002lww.2	-	3	425	c.162G>T	c.(160-162)ACG>ACT	p.T54T	TLE2_uc010xhb.1_5'Flank|TLE2_uc010dth.2_Silent_p.T54T|TLE2_uc010xhc.1_5'UTR|TLE2_uc010dti.2_Silent_p.T67T|TLE2_uc010xhd.1_Silent_p.T54T	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	54	Gln-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGCATTTCCGTCTTCTCGC	0.507													4	10					0.000602214	0.000620712	1	0	A	3028341	A	A	3028341	2	1	261	1	0	0	0	0	0	0	0	1	16005	639	23	3		3	TLE2	19	3028341	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	917520	3028341	56100642	438	47814											
DOHH	83475	broad.mit.edu	37	chr19	3494056	3494056	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggtccgaggaatactgcttCaggatctccagaacttccgg	9	9	12	11	2	2	1	1	0	1	1	5	4	4	3	3	4	3	1	3	4	3	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:3494056C>T	uc002lxs.2	-	3	484	c.321G>A	c.(319-321)CTG>CTA	p.L107L	DOHH_uc010xhl.1_Silent_p.L107L	NM_031304	NP_112594	Q9BU89	DOHH_HUMAN	deoxyhypusine hydroxylase/monooxygenase	107	HEAT-like PBS-type 2.				peptidyl-lysine modification to hypusine|post-translational protein modification	cytosol	deoxyhypusine monooxygenase activity|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		AATACTGCTTCAGGATCTCCA	0.642													4	15					0	0	0	0	T	3494056	T	T	3494056	2	4	261	1	0	0	0	0	0	0	0	1	4717	813	29	2		2	DOHH	19	3494056	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	465715	3494056	55634927	439	47815											
DOHH	83475	broad.mit.edu	37	chr19	3494073	3494073	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttcaggatctccagaacttCcgggtccccgatggccccca	7	8	9	17	2	2	1	1	0	1	1	5	3	4	2	6	3	1	0	6	3	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:3494073C>T	uc002lxs.2	-	3	467	c.304G>A	c.(304-306)GAA>AAA	p.E102K	DOHH_uc010xhl.1_Missense_Mutation_p.E102K	NM_031304	NP_112594	Q9BU89	DOHH_HUMAN	deoxyhypusine hydroxylase/monooxygenase	102	HEAT-like PBS-type 2.				peptidyl-lysine modification to hypusine|post-translational protein modification	cytosol	deoxyhypusine monooxygenase activity|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCAGAACTTCCGGGTCCCCG	0.632													5	14					0	0	0	0	T	3494073	T	T	3494073	3	4	261	1	0	0	0	0	1	0	0	0	4717	864	30	2	616	2	DOHH	19	3494073	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	17	3494073	55634910	440	47816											
SAFB2	9667	broad.mit.edu	37	chr19	5622555	5622555	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cctcaccttcttgagccgctCcatcaggacgctcttgttgc	5	12	8	16	2	4	1	2	1	2	0	5	2	5	2	4	1	2	3	4	1	0	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:5622555C>G	uc002mcd.2	-	1	384	c.172G>C	c.(172-174)GAG>CAG	p.E58Q	SAFB_uc010xiq.1_5'Flank|SAFB_uc002mcf.2_5'Flank|SAFB_uc002mcg.2_5'Flank|SAFB_uc002mce.3_5'Flank|SAFB_uc010xir.1_5'Flank|SAFB_uc010xis.1_5'Flank|SAFB_uc010xit.1_5'Flank|SAFB_uc010xiu.1_5'Flank|SAFB2_uc010xio.1_Missense_Mutation_p.E58Q|SAFB2_uc010xip.1_RNA	NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	58	SAP.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TTGAGCCGCTCCATCAGGACG	0.731													8	12					0	0	0	0	G	5622555	G	G	5622555	3	3	261	1	0	0	0	0	1	0	0	0	13872	864	30	2	2773	2	SAFB2	19	5622555	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	2128482	5622555	53506428	441	47817											
RFX2	5990	broad.mit.edu	37	chr19	6007164	6007164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgggcaggacggcgccctCggggtcttcgtcactgtgga	4	9	16	12	4	2	0	1	0	1	0	4	2	2	2	1	6	0	1	1	6	0	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:6007164C>T	uc002meb.2	-	12	1530	c.1261G>A	c.(1261-1263)GAG>AAG	p.E421K	RFX2_uc002mec.2_Missense_Mutation_p.E396K|RFX2_uc002med.1_3'UTR	NM_000635	NP_000626	P48378	RFX2_HUMAN	regulatory factor X2 isoform a	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|ovary(1)|skin(1)	6						ACGGCGCCCTCGGGGTCTTCG	0.667													7	27					0	0	0	0	T	6007164	T	T	6007164	3	4	261	1	0	0	0	0	1	0	0	0	13328	893	31	1	938	1	RFX2	19	6007164	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	384609	6007164	53121819	442	47818											
TNFSF14	8740	broad.mit.edu	37	chr19	6665352	6665352	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccccgctgccggtcaagctgGagttggcccctgttgggaag	5	8	15	13	2	1	0	1	0	0	0	1	2	1	2	5	4	2	4	5	4	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:6665352G>C	uc002mfk.1	-	5	690	c.308C>G	c.(307-309)TCC>TGC	p.S103C	TNFSF14_uc002mfj.1_Missense_Mutation_p.S67C	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	103	Extracellular (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						GGTCAAGCTGGAGTTGGCCCC	0.532													3	3					0	0	0	0	C	6665352	C	C	6665352	3	2	261	1	0	0	0	0	1	0	0	0	16373	1174	41	2	418	2	TNFSF14	19	6665352	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	658188	6665352	52463631	443	47819											
VAV1	7409	broad.mit.edu	37	chr19	6833552	6833552	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctcagaggtaccttctatCagggctaccgctgccatcgg	8	10	10	13	2	3	1	2	0	2	1	5	1	3	1	3	3	3	3	3	3	3	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:6833552C>G	uc002mfu.1	+	17	1721	c.1624C>G	c.(1624-1626)CAG>GAG	p.Q542E	VAV1_uc010xjh.1_Missense_Mutation_p.Q510E|VAV1_uc010dva.1_Missense_Mutation_p.Q542E|VAV1_uc002mfv.1_Missense_Mutation_p.Q487E	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	542	Phorbol-ester/DAG-type.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						TACCTTCTATCAGGGCTACCG	0.547													20	95					0	0	0	0	G	6833552	G	G	6833552	3	3	261	1	0	0	0	0	1	0	0	0	17199	827	29	2	1690	2	VAV1	19	6833552	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	168200	6833552	52295431	444	47820											
MYO1F	4542	broad.mit.edu	37	chr19	8587564	8587564	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggaattctgtgttgtgctCtgagggcggacgtgcccggg	5	10	18	8	3	2	1	0	1	2	0	2	4	2	3	1	4	2	2	1	4	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:8587564C>T	uc002mkg.2	-	26	3118	c.3004G>A	c.(3004-3006)GAG>AAG	p.E1002K		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	1002						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GTGTTGTGCTCTGAGGGCGGA	0.687													7	24					0	0	0	0	T	8587564	T	T	8587564	3	4	261	1	0	0	0	0	1	0	0	0	10126	922	32	2	304	2	MYO1F	19	8587564	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1754012	8587564	50541419	445	47821											
ADAMTS10	81794	broad.mit.edu	37	chr19	8650504	8650504	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcggctgcgcacgcctgcatCgcagctgcggctgcagagcg	5	5	16	15	6	0	1	0	0	0	1	1	1	0	1	1	2	6	7	1	2	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:8650504C>T	uc002mkj.1	-	23	2975	c.2701G>A	c.(2701-2703)GAT>AAT	p.D901N	ADAMTS10_uc002mki.1_Missense_Mutation_p.D388N|ADAMTS10_uc002mkk.1_Missense_Mutation_p.D533N	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	901	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						ACGCCTGCATCGCAGCTGCGG	0.672													7	13					0	0	0	0	T	8650504	T	T	8650504	3	4	261	1	0	0	0	0	1	0	0	0	256	884	31	1	626	1	ADAMTS10	19	8650504	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	62940	8650504	50478479	446	47822											
ZNF177	7730	broad.mit.edu	37	chr19	9492159	9492159	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcgatcagtcatcccttaaGaaacacacacgctctcacac	14	8	4	15	2	3	1	3	0	1	1	6	2	4	1	1	0	1	1	1	0	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:9492159G>C	uc002mli.2	+	12	1335	c.672G>C	c.(670-672)AAG>AAC	p.K224N	ZNF177_uc002mlj.2_Missense_Mutation_p.K174N|ZNF177_uc002mlk.2_Missense_Mutation_p.K224N	NM_003451	NP_003442	Q13360	ZN177_HUMAN	zinc finger protein 177	224	C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATCCCTTAAGAAACACACAC	0.463													16	131					0	0	0	0	C	9492159	C	C	9492159	3	2	261	1	0	0	0	0	1	0	0	0	17813	933	33	2	1170	2	ZNF177	19	9492159	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	841655	9492159	49636824	447	47823											
EIF3G	8666	broad.mit.edu	37	chr19	10226442	10226442	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggaagagctcctgcaggtcgGtctcacgcgtgtcctctgac	6	9	13	13	3	2	2	1	1	2	1	6	3	4	3	2	3	2	2	2	3	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:10226442G>T	uc002mnd.2	-	9	822	c.758C>A	c.(757-759)ACC>AAC	p.T253N		NM_003755	NP_003746	O75821	EIF3G_HUMAN	eukaryotic translation initiation factor 3,	253	RRM.					cytosol|eukaryotic translation initiation factor 3 complex|nucleus|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0			OV - Ovarian serous cystadenocarcinoma(20;3.53e-09)|Epithelial(33;4.91e-06)|all cancers(31;1.1e-05)			CTGCAGGTCGGTCTCACGCGT	0.632													17	57					2.94398e-08	3.13057e-08	1	0	T	10226442	T	T	10226442	3	4	261	1	0	0	0	0	1	0	0	0	5041	1261	44	4	216	4	EIF3G	19	10226442	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	734283	10226442	48902541	448	47824											
DNM2	1785	broad.mit.edu	37	chr19	10870479	10870479	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattctgcagctcatcttctCaaaaacaggtaaaatggggc	13	10	8	10	0	4	0	2	0	3	0	5	0	4	0	0	3	3	3	0	3	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:10870479C>T	uc002mps.1	+	2	391	c.227C>T	c.(226-228)TCA>TTA	p.S76L	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Missense_Mutation_p.S76L|DNM2_uc002mpv.1_Missense_Mutation_p.S76L|DNM2_uc002mpu.1_Missense_Mutation_p.S76L|DNM2_uc010dxl.1_Missense_Mutation_p.S76L	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	76					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CTCATCTTCTCAAAAACAGGT	0.577													33	97					0	0	0	0	T	10870479	T	T	10870479	3	4	261	1	0	0	0	0	1	0	0	0	4694	838	29	2	233	2	DNM2	19	10870479	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	644037	10870479	48258504	449	47825											
YIPF2	78992	broad.mit.edu	37	chr19	11036435	11036435	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggggcagcagtgagcctttGatccggtccaggacctgggg	6	7	17	11	2	0	2	0	2	0	0	2	3	2	3	4	6	2	2	4	6	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:11036435G>A	uc002mqb.2	-	5	418	c.294C>T	c.(292-294)ATC>ATT	p.I98I	YIPF2_uc002mqc.2_Silent_p.I98I|C19orf52_uc002mqd.1_5'Flank	NM_024029	NP_076934	Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	98	Cytoplasmic (Potential).					integral to membrane|transport vesicle					0						GTGAGCCTTTGATCCGGTCCA	0.602													8	18					0	0	0	0	A	11036435	A	A	11036435	2	1	261	1	0	0	0	0	0	0	0	1	17546	1280	45	2		2	YIPF2	19	11036435	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	165956	11036435	48092548	450	47826											
ZNF136	7695	broad.mit.edu	37	chr19	12297854	12297854	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaaagaagtcacactggaGagaaaccctatgaatgtcag	17	7	10	7	0	2	4	2	2	0	2	2	6	2	5	1	1	1	0	1	1	5	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:12297854G>C	uc002mti.2	+	4	761	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	ZNF136_uc010xmh.1_Missense_Mutation_p.E155Q	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	221					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						TCACACTGGAGAGAAACCCTA	0.398													17	33					0	0	0	0	C	12297854	C	C	12297854	3	2	261	1	0	0	0	0	1	0	0	0	17793	943	33	2	675	2	ZNF136	19	12297854	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1261419	12297854	46831129	451	47827											
ZNF44	51710	broad.mit.edu	37	chr19	12383859	12383859	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctttgaaatacactaggaGaatcaaaggctttcccacat	14	11	7	9	0	2	2	1	1	1	1	3	3	3	2	1	2	1	1	1	2	5	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:12383859G>A	uc010xmj.1	-	5	1560	c.1355C>T	c.(1354-1356)TCT>TTT	p.S452F	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.S404F	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	452	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		TACACTAGGAGAATCAAAGGC	0.453													10	42					0	0	0	0	A	12383859	A	A	12383859	3	1	261	1	0	0	0	0	1	0	0	0	17979	942	33	2	640	2	ZNF44	19	12383859	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	86005	12383859	46745124	452	47828											
HOOK2	29911	broad.mit.edu	37	chr19	12883482	12883482	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attcttccagcgtcatgattCtctggatgtggtctggggat	6	15	12	8	1	4	1	1	1	3	0	6	3	5	3	1	4	1	0	1	4	0	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:12883482C>G	uc002muy.2	-	6	572	c.401G>C	c.(400-402)AGA>ACA	p.R134T	HOOK2_uc002muz.2_Missense_Mutation_p.R134T	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	134	Sufficient for interaction with microtubules.|Required for localization to the centrosome and induction of aggresome formation.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						CGTCATGATTCTCTGGATGTG	0.582													13	125					0	0	0	0	G	12883482	G	G	12883482	3	3	261	1	0	0	0	0	1	0	0	0	7322	913	32	2	1830	2	HOOK2	19	12883482	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	499623	12883482	46245501	453	47829											
CACNA1A	773	broad.mit.edu	37	chr19	13356019	13356019	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaactcagtcacgaggatatCggtgatgctgcccagaacag	13	7	11	10	2	2	2	2	1	0	1	3	4	2	3	1	2	4	1	1	2	3	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:13356019C>T	uc010dze.2	-	31	5166	c.4930G>A	c.(4930-4932)GAT>AAT	p.D1644N	CACNA1A_uc010xnd.1_Missense_Mutation_p.D349N|CACNA1A_uc002mwx.3_Missense_Mutation_p.D349N|CACNA1A_uc010dzc.2_Missense_Mutation_p.D1169N|CACNA1A_uc002mwy.3_Missense_Mutation_p.D1643N|CACNA1A_uc010xne.1_Missense_Mutation_p.D1172N|CACNA1A_uc002mwv.3_Missense_Mutation_p.D160N	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1644	Helical; Name=S3 of repeat IV; (Potential).|IV.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ACGAGGATATCGGTGATGCTG	0.582													18	38					0	0	0	0	T	13356019	T	T	13356019	3	4	261	1	0	0	0	0	1	0	0	0	2550	884	31	1	2763	1	CACNA1A	19	13356019	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	472537	13356019	45772964	454	47830											
MYO9B	4650	broad.mit.edu	37	chr19	17311114	17311114	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctgcagatccacgtttaaGaggctttttctgcataaaac	11	13	7	10	1	1	2	0	0	1	2	3	2	3	2	2	1	3	4	2	1	3	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:17311114G>C	uc010eak.2	+	25	4403	c.4251G>C	c.(4249-4251)AAG>AAC	p.K1417N	MYO9B_uc002nfi.2_Missense_Mutation_p.K1417N|MYO9B_uc002nfj.1_Missense_Mutation_p.K1417N|MYO9B_uc002nfl.1_5'UTR	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1417	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CCACGTTTAAGAGGCTTTTTC	0.502													4	22					0	0	0	0	C	17311114	C	C	17311114	3	2	261	1	0	0	0	0	1	0	0	0	10138	933	33	2	4345	2	MYO9B	19	17311114	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3955095	17311114	41817869	455	47831											
MAP1S	55201	broad.mit.edu	37	chr19	17835961	17835961	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctacagacagggggcttctCgcctcaccacttcctccagg	7	8	10	16	1	2	1	1	0	1	1	5	1	4	1	4	3	1	2	4	3	1	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:17835961C>T	uc002nhe.1	+	4	416	c.407C>T	c.(406-408)TCG>TTG	p.S136L	MAP1S_uc010eaz.1_RNA|MAP1S_uc010eba.1_Missense_Mutation_p.S136L|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Missense_Mutation_p.S110L	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	136	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						GGGGGCTTCTCGCCTCACCAC	0.612													21	63					0	0	0	0	T	17835961	T	T	17835961	3	4	261	1	0	0	0	0	1	0	0	0	9287	893	31	1	421	1	MAP1S	19	17835961	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	524847	17835961	41293022	456	47832											
ZNF43	7594	broad.mit.edu	37	chr19	21992317	21992317	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgccacattctttgcatttGaaaagttttttttcagtatg	9	20	6	6	0	2	1	1	1	1	0	2	1	2	1	1	0	2	3	1	0	3	9			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:21992317G>A	uc002nqj.2	-	4	652	c.522C>T	c.(520-522)TTC>TTT	p.F174F	ZNF43_uc010ecv.2_Silent_p.F168F|ZNF43_uc002nql.2_Silent_p.F168F|ZNF43_uc002nqm.2_Silent_p.F168F|ZNF43_uc002nqk.2_Silent_p.F104F	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	174	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		CTTTGCATTTGAAAAGTTTTT	0.303													11	13					0	0	0	0	A	21992317	A	A	21992317	2	1	261	1	0	0	0	0	0	0	0	1	17970	1281	45	2		2	ZNF43	19	21992317	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4156356	21992317	37136666	457	47833											
ZNF208	7757	broad.mit.edu	37	chr19	22155770	22155770	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cacatttgtagggtttctctCcagtatgaattaccttatgt	9	17	7	8	0	1	1	0	1	1	0	3	1	2	1	2	1	1	3	2	1	5	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:22155770C>G	uc002nqp.2	-	5	1915	c.1766G>C	c.(1765-1767)GGA>GCA	p.G589A	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGGTTTCTCTCCAGTATGAAT	0.383													12	42					0	0	0	0	G	22155770	G	G	22155770	3	3	261	1	0	0	0	0	1	0	0	0	17833	855	30	2	1780	2	ZNF208	19	22155770	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	163453	22155770	36973213	458	47834											
ZNF345	25850	broad.mit.edu	37	chr19	37368436	37368436	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttatgaatgcaaagcatGtggaatggcctttagcagtg	12	11	11	7	0	0	1	0	1	0	0	0	2	0	2	2	2	3	3	2	2	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:37368436G>C	uc002oex.2	+	3	1082	c.704G>C	c.(703-705)TGT>TCT	p.C235S	ZNF345_uc002oey.3_Missense_Mutation_p.C235S|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	235	C2H2-type 7.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGCAAAGCATGTGGAATGGCC	0.418													19	57					0	0	0	0	C	37368436	C	C	37368436	3	2	261	1	0	0	0	0	1	0	0	0	17926	1377	48	4	706	4	ZNF345	19	37368436	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	15212666	37368436	21760547	459	47835											
DLL3	10683	broad.mit.edu	37	chr19	39989650	39989650	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtccgggctcctctcccaGactgtgatcctagcgctcat	6	11	9	15	2	2	2	1	1	1	1	6	2	5	2	4	1	1	2	4	1	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:39989650G>A	uc002olx.2	+	1	94	c.36G>A	c.(34-36)CAG>CAA	p.Q12Q	DLL3_uc010egq.2_Silent_p.Q12Q|DLL3_uc002olw.2_Silent_p.Q12Q	NM_016941	NP_058637	Q9NYJ7	DLL3_HUMAN	delta-like 3 protein isoform 1 precursor	12					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			central_nervous_system(2)|breast(1)	3	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TCCTCTCCCAGACTGTGATCC	0.617													22	79					0	0	0	0	A	39989650	A	A	39989650	2	1	261	1	0	0	0	0	0	0	0	1	4589	933	33	2		2	DLL3	19	39989650	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2621214	39989650	19139333	460	47836											
ERF	2077	broad.mit.edu	37	chr19	42753748	42753748	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgggccaccacagccgagaaGagggaagatgaagatgaaga	16	2	15	8	2	0	7	0	2	0	5	0	9	0	8	3	2	1	0	3	2	4	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:42753748G>A	uc002ote.3	-	4	674	c.516C>T	c.(514-516)CTC>CTT	p.L172L	ERF_uc002otd.3_5'UTR	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	172					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)				CAGCCGAGAAGAGGGAAGATG	0.657													13	58					0	0	0	0	A	42753748	A	A	42753748	2	1	261	1	0	0	0	0	0	0	0	1	5245	929	33	2		2	ERF	19	42753748	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2764098	42753748	16375235	461	47837											
MEGF8	1954	broad.mit.edu	37	chr19	42875617	42875617	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctcccccagtgaccgtcgaGactgctacaagtaccaggtg	9	7	11	14	2	0	2	0	1	0	1	2	3	1	2	4	1	3	3	4	1	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:42875617G>C	uc002otl.3	+	40	7686	c.7051G>C	c.(7051-7053)GAC>CAC	p.D2351H	MEGF8_uc002otm.3_Missense_Mutation_p.D1959H|MEGF8_uc002otn.3_Intron	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2418	Extracellular (Potential).|Laminin EGF-like 4.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				TGACCGTCGAGACTGCTACAA	0.627													9	44					0	0	0	0	C	42875617	C	C	42875617	3	2	261	1	0	0	0	0	1	0	0	0	9516	942	33	2	7209	2	MEGF8	19	42875617	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	121869	42875617	16253366	462	47838											
GYS1	2997	broad.mit.edu	37	chr19	49477904	49477904	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcggcactgctattgaaGaggccgattcggcggatggt	7	10	15	9	4	0	2	0	1	0	1	2	4	0	3	1	5	1	2	1	5	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:49477904G>A	uc002plp.2	-	11	1636	c.1395C>T	c.(1393-1395)CTC>CTT	p.L465L	GYS1_uc010xzy.1_Silent_p.L98L|GYS1_uc010emm.2_Silent_p.L401L|GYS1_uc010xzz.1_Silent_p.L385L|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	465					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TGCTATTGAAGAGGCCGATTC	0.617													8	32					0	0	0	0	A	49477904	A	A	49477904	2	1	261	1	0	0	0	0	0	0	0	1	6951	929	33	2		2	GYS1	19	49477904	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	6602287	49477904	9651079	463	47839											
ZNF175	7728	broad.mit.edu	37	chr19	52091027	52091027	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tatcagtgccacaactgtggGaaatccttcatttccaagtc	11	12	7	11	0	2	0	2	0	0	0	5	1	4	1	3	1	2	0	3	1	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:52091027G>A	uc002pxb.2	+	5	1821	c.1443G>A	c.(1441-1443)GGG>GGA	p.G481G		NM_007147	NP_009078	Q9Y473	ZN175_HUMAN	zinc finger protein 175	481	C2H2-type 8.				response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		ACAACTGTGGGAAATCCTTCA	0.448													11	19					0	0	0	0	A	52091027	A	A	52091027	2	1	261	1	0	0	0	0	0	0	0	1	17812	1161	41	2		2	ZNF175	19	52091027	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2613123	52091027	7037956	464	47840											
LILRB4	11006	broad.mit.edu	37	chr19	55179456	55179456	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcccagtgtctatgccactCtggccatccactaatccagg	9	9	8	15	0	2	0	0	0	2	0	4	0	4	0	5	2	2	0	5	2	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:55179456C>G	uc002qgp.2	+	12	1695	c.1333C>G	c.(1333-1335)CTG>GTG	p.L445V	LILRB4_uc002qgq.2_Missense_Mutation_p.L444V|LILRB4_uc002qgr.2_Missense_Mutation_p.L487V|LILRB4_uc010ert.2_Missense_Mutation_p.L486V|LILRB4_uc010eru.2_Missense_Mutation_p.L475V	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	445	ITIM motif 3.|Cytoplasmic (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		CTATGCCACTCTGGCCATCCA	0.597													15	59					0	0	0	0	G	55179456	G	G	55179456	3	3	261	1	0	0	0	0	1	0	0	0	8834	912	32	2	1379	2	LILRB4	19	55179456	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	3088429	55179456	3949527	465	47841											
ZNF444	55311	broad.mit.edu	37	chr19	56658417	56658417	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgctccgcgccctgtgccGggactggctgcggcccgagg	2	6	17	16	5	0	0	0	0	0	0	1	2	1	1	4	4	3	3	4	4	0	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:56658417G>T	uc002qmm.2	+	3	504	c.137G>T	c.(136-138)CGG>CTG	p.R46L	ZNF444_uc002qmn.1_Missense_Mutation_p.R46L	NM_018337	NP_060807	Q8N0Y2	ZN444_HUMAN	zinc finger protein 444	46	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0531)		GCCCTGTGCCGGGACTGGCTG	0.746													4	5					0.00024832	0.000257707	1	0	T	56658417	T	T	56658417	3	4	261	1	0	0	0	0	1	0	0	0	17984	1116	39	3	139	3	ZNF444	19	56658417	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1478961	56658417	2470566	466	47842											
ZNF418	147686	broad.mit.edu	37	chr19	58439254	58439254	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgatgtgtcccctgatgatCtgccaagtgcaaaatgtctc	9	12	10	10	0	2	3	0	3	2	0	4	3	3	3	3	0	2	1	3	0	3	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:58439254C>T	uc002qqs.1	-	4	587	c.295G>A	c.(295-297)GAT>AAT	p.D99N	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.D14N	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	99	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CCCTGATGATCTGCCAAGTGC	0.512													21	92					0	0	0	0	T	58439254	T	T	58439254	3	4	261	1	0	0	0	0	1	0	0	0	17962	913	32	2	1739	2	ZNF418	19	58439254	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1780837	58439254	689729	467	47843											
SIRPB1	10326	broad.mit.edu	37	chr20	1559329	1559329	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatcacctgtagctcgtcctCacctgccactcctggaaagg	9	9	8	15	1	2	0	2	0	0	0	5	1	4	1	5	2	2	2	5	2	3	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:1559329C>G	uc010gai.2	-	2	187	c.88G>C	c.(88-90)GAG>CAG	p.E30Q	SIRPB1_uc002wfk.3_Missense_Mutation_p.E30Q	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	30	Extracellular (Potential).|Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						AGCTCGTCCTCACCTGCCACT	0.507													7	93					0	0	0	0	G	1559329	G	G	1559329	3	3	261	1	0	0	0	0	1	0	0	0	14398	835	29	2	1124	2	SIRPB1	20	1559329	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08		1559329	61466191	468	47844											
XKR7	343702	broad.mit.edu	37	chr20	30584822	30584822	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcatattcttcatgtgtgtCtactactgtctcctgcaccc	6	15	7	13	0	4	0	1	0	3	0	5	0	4	0	2	1	3	2	2	1	3	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:30584822C>G	uc002wxe.2	+	3	1476	c.1302C>G	c.(1300-1302)GTC>GTG	p.V434V		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	434	Helical; (Potential).					integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TCATGTGTGTCTACTACTGTC	0.587													15	46					0	0	0	0	G	30584822	G	G	30584822	2	3	261	1	0	0	0	0	0	0	0	1	17504	900	32	2		2	XKR7	20	30584822	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	29025493	30584822	32440698	469	47845											
ASXL1	171023	broad.mit.edu	37	chr20	31022345	31022345	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgccggggttggactggCgccaggaccctcgcagacat	6	7	14	14	3	0	1	0	0	0	1	2	3	1	3	4	5	1	2	4	5	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:31022345C>T	uc002wxs.2	+	12	2256	c.1830C>T	c.(1828-1830)GGC>GGT	p.G610G	ASXL1_uc010geb.2_Silent_p.G501G	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	610					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.Q592fs*5(1)|p.G610G(1)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GTTGGACTGGCGCCAGGACCC	0.632			F|N|Mis		MDS|CMML								8	31					0	0	0	0	T	31022345	T	T	31022345	2	4	261	1	0	0	0	0	0	0	0	1	1068	755	27	1		1	ASXL1	20	31022345	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	437523	31022345	32003175	470	47846											
RPN2	6185	broad.mit.edu	37	chr20	35827507	35827508	+	Missense_Mutation	DNP	TC	AA	AA																															tggcagctgtcagtgaggacTcatctgttacccagatctac																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:35827507_35827508TC>AA	uc002xgp.2	+	4	662_663	c.358_359TC>AA	c.(358-360)TCA>AAA	p.S120K	RPN2_uc002xgo.3_Missense_Mutation_p.S120K|RPN2_uc010gfw.2_Intron|RPN2_uc002xgq.2_Missense_Mutation_p.S88K	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	120	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CAGTGAGGACTCATCTGTTACC	0.48													22	69					0	0	0	0	AA	35827508	AA	AA	35827507	3	1	261	1	0	0	0	0	1	0	0	0	13673	1551	54	5	372	5	RPN2	20	35827507	Missense_Mutation	DNP	TC	TCGA-CV-7427-01A-11D-2078-08	4805162	35827507	27198013	471	47847											
HNF4A	3172	broad.mit.edu	37	chr20	43047076	43047076	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctttcaggtggccctgctCagagcccatgctggcgagca	6	9	12	14	1	3	1	2	0	1	1	3	2	3	1	2	3	4	3	2	3	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:43047076C>T	uc002xma.2	+	6	749	c.660C>T	c.(658-660)CTC>CTT	p.L220L	HNF4A_uc002xlt.2_Silent_p.L198L|HNF4A_uc002xlu.2_Silent_p.L198L|HNF4A_uc002xlv.2_Silent_p.L198L|HNF4A_uc002xly.2_Silent_p.L220L|HNF4A_uc002xlz.2_Silent_p.L220L|HNF4A_uc010ggq.2_Silent_p.L213L	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	220					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TGGCCCTGCTCAGAGCCCATG	0.483													25	84					0	0	0	0	T	43047076	T	T	43047076	2	4	261	1	0	0	0	0	0	0	0	1	7292	813	29	2		2	HNF4A	20	43047076	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7219569	43047076	19978444	472	47848											
KCNK15	60598	broad.mit.edu	37	chr20	43379022	43379022	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cctcggggccgtcgccttctCgcacttcgagggctggacct	3	9	13	16	5	1	0	0	0	1	0	5	2	1	1	4	4	0	2	4	4	0	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:43379022C>G	uc002xmr.2	+	2	600	c.536C>G	c.(535-537)TCG>TGG	p.S179W		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	179	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				GTCGCCTTCTCGCACTTCGAG	0.677													4	19					0	0	0	0	G	43379022	G	G	43379022	3	3	261	1	0	0	0	0	1	0	0	0	8101	893	31	3	542	3	KCNK15	20	43379022	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	331946	43379022	19646498	473	47849											
ARFGEF2	10564	broad.mit.edu	37	chr20	47582443	47582443	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catggtctgacagaacctgaGagagttctaggtgaactgga	12	9	13	7	0	2	5	0	3	2	2	2	7	2	6	1	3	2	1	1	3	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:47582443G>C	uc002xtx.3	+	8	1094	c.942G>C	c.(940-942)GAG>GAC	p.E314D		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	314					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CAGAACCTGAGAGAGTTCTAG	0.473													14	67					0	0	0	0	C	47582443	C	C	47582443	3	2	261	1	0	0	0	0	1	0	0	0	853	933	33	2	972	2	ARFGEF2	20	47582443	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4203421	47582443	15443077	474	47850											
ADNP	23394	broad.mit.edu	37	chr20	49510683	49510683	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaaggtgctgccacatgctGaaaatgttccctgtaaatgt	11	12	10	8	0	0	1	0	1	0	0	1	1	1	1	2	1	3	5	2	1	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:49510683G>C	uc002xvt.1	-	5	913	c.568C>G	c.(568-570)CAG>GAG	p.Q190E	ADNP_uc002xvu.1_Missense_Mutation_p.Q190E	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	190						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						GCCACATGCTGAAAATGTTCC	0.448													24	82					0	0	0	0	C	49510683	C	C	49510683	3	2	261	1	0	0	0	0	1	0	0	0	323	1299	45	2	2744	2	ADNP	20	49510683	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1928240	49510683	13514837	475	47851											
NFATC2	4773	broad.mit.edu	37	chr20	50049030	50049030	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccatgagggccggctgctGatagcccagcaggctggggc	6	5	18	12	1	0	2	0	2	0	0	0	2	0	2	3	6	3	4	3	6	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:50049030G>A	uc002xwd.2	-	9	2516	c.2296C>T	c.(2296-2298)CAG>TAG	p.Q766*	NFATC2_uc002xwc.2_Nonsense_Mutation_p.Q766*|NFATC2_uc010zyv.1_Nonsense_Mutation_p.Q547*|NFATC2_uc010zyw.1_Nonsense_Mutation_p.Q547*|NFATC2_uc010zyx.1_Nonsense_Mutation_p.Q746*|NFATC2_uc010zyy.1_Nonsense_Mutation_p.Q547*|NFATC2_uc010zyz.1_Nonsense_Mutation_p.Q547*|NFATC2_uc002xwe.2_Nonsense_Mutation_p.Q746*	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	766					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GCCGGCTGCTGATAGCCCAGC	0.697													5	18					0	0	0	0	A	50049030	A	A	50049030	4	1	261	1	0	0	0	0	0	1	0	0	10416	1299	45	2	537	2	NFATC2	20	50049030	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	538347	50049030	12976490	476	47852											
LIPI	149998	broad.mit.edu	37	chr21	15561416	15561416	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctggtgtttttaactgctCtattataaataaaagttgta	12	19	6	4	0	2	0	0	0	2	0	2	0	2	0	0	1	2	4	0	1	8	10			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr21:15561416C>G	uc002yjm.2	-	2	444	c.434G>C	c.(433-435)AGA>ACA	p.R145T	LIPI_uc010gkw.1_Missense_Mutation_p.R78T	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	124					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTTAACTGCTCTATTATAAAT	0.338													5	43					0	0	0	0	G	15561416	G	G	15561416	3	3	261	1	0	0	0	0	1	0	0	0	8867	913	32	2	1047	2	LIPI	21	15561416	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08		15561416	32568479	477	47853											
TMPRSS15	5651	broad.mit.edu	37	chr21	19725330	19725331	+	Frame_Shift_Ins	INS	-	A	A																															tagatcctggacccagaaacINSaaaagccatcctcaaagtta																										TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr21:19725330_19725331insA	uc002ykw.2	-	10	1091_1092	c.1060_1061insT	c.(1060-1062)TGTfs	p.C354fs		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	354	Extracellular (Potential).|MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity	p.C354F(1)		ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						GACCCAGAAACAAAAGCCATCC	0.332													---	---	---								A	19725331	A	A	19725330	7	5	261	1	0	1	1	0	0	0	0	0	16312	478	17	0	2062	0	TMPRSS15	21	19725330	Frame_Shift_Ins	INS	-	TCGA-CV-7427-01A-11D-2078-08	4163914	19725330	28404565	478	47854											
SUMO3	6612	broad.mit.edu	37	chr21	46226908	46226908	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctctccggcacacctccCgtctgctgctggaacacgtc	5	9	9	18	3	2	0	0	0	2	0	5	1	3	1	3	2	4	4	3	2	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr21:46226908C>T	uc002zfz.1	-	4	431	c.270G>A	c.(268-270)ACG>ACA	p.T90T	SUMO3_uc011afi.1_Silent_p.T128T|SUMO3_uc002zga.1_Missense_Mutation_p.R107Q	NM_006936	NP_008867	P55854	SUMO3_HUMAN	small ubiquitin-like modifier protein 3	90	Ubiquitin-like.				protein sumoylation	cytoplasm|kinetochore	protein binding				0				Colorectal(79;0.058)		GCACACCTCCCGTCTGCTGCT	0.612													10	35					0	0	0	0	T	46226908	T	T	46226908	2	4	261	1	0	0	0	0	0	0	0	1	15455	639	23	1		1	SUMO3	21	46226908	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	26501578	46226908	1902987	479	47855											
COL6A2	1292	broad.mit.edu	37	chr21	47546045	47546045	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcacgagagtgaaaacctCtactccatcgcctgcgacaa	14	6	8	13	3	1	2	0	1	1	1	3	4	2	2	3	0	4	1	3	0	5	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr21:47546045C>G	uc002zia.1	+	26	2398	c.2316C>G	c.(2314-2316)CTC>CTG	p.L772L	COL6A2_uc002zhy.1_Silent_p.L772L|COL6A2_uc002zhz.1_Silent_p.L772L|COL6A2_uc002zib.1_Silent_p.L178L|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	772	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GTGAAAACCTCTACTCCATCG	0.587													48	143					0	0	0	0	G	47546045	G	G	47546045	2	3	261	1	0	0	0	0	0	0	0	1	3715	900	32	2		2	COL6A2	21	47546045	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1319137	47546045	583850	480	47856											
PI4KA	5297	broad.mit.edu	37	chr22	21104247	21104247	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatggcctcctggaggatCatcccacagcgtgcagcgaa	9	8	11	13	2	2	0	2	0	0	0	4	3	4	2	3	3	3	1	3	3	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:21104247C>T	uc002zsz.3	-	28	3246	c.3015G>A	c.(3013-3015)ATG>ATA	p.M1005I		NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	1005					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCTGGAGGATCATCCCACAGC	0.527													8	30					0	0	0	0	T	21104247	T	T	21104247	3	4	261	1	0	0	0	0	1	0	0	0	11928	826	29	2	3231	2	PI4KA	22	21104247	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08		21104247	30200319	481	47857											
RAB36	9609	broad.mit.edu	37	chr22	23495243	23495243	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgcaagaatgtttttgatcGagactacaaggccaccattg	12	12	9	8	1	0	3	0	1	0	2	1	4	0	3	2	1	2	2	2	1	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:23495243G>A	uc002zwv.1	+	5	489	c.449G>A	c.(448-450)CGA>CAA	p.R150Q	RAB36_uc010gtw.1_Missense_Mutation_p.R128Q	NM_004914	NP_004905	O95755	RAB36_HUMAN	RAB36, member RAS oncogene family	150					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.155)		GTTTTTGATCGAGACTACAAG	0.493													23	97					0	0	0	0	A	23495243	A	A	23495243	3	1	261	1	0	0	0	0	1	0	0	0	12991	1058	37	1	467	1	RAB36	22	23495243	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	2390996	23495243	27809323	482	47858											
CYTSA	23384	broad.mit.edu	37	chr22	24759250	24759250	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcatctgttaagaacatcttCagccagccggcctgcttccc	8	10	8	15	1	3	1	1	0	2	1	4	1	4	1	4	1	4	3	4	1	2	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:24759250C>T	uc002zzw.2	+	12	3072	c.2765C>T	c.(2764-2766)TCA>TTA	p.S922L	CYTSA_uc002zzv.3_Missense_Mutation_p.S922L|CYTSA_uc011ajq.1_Missense_Mutation_p.S922L	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	922					cell cycle|cell division						0						AGAACATCTTCAGCCAGCCGG	0.403													13	28					0	0	0	0	T	24759250	T	T	24759250	3	4	261	1	0	0	0	0	1	0	0	0	4226	838	29	2	2803	2	CYTSA	22	24759250	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1264007	24759250	26545316	483	47859											
OSM	5008	broad.mit.edu	37	chr22	30660370	30660370	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccgcctgcccagccccctCagggtctcctcactggggaa	5	6	10	20	1	3	0	2	0	1	0	4	1	3	1	7	3	2	0	7	3	1	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:30660370C>T	uc003ahb.2	-	3	313	c.261G>A	c.(259-261)CTG>CTA	p.L87L		NM_020530	NP_065391	P13725	ONCM_HUMAN	oncostatin M precursor	87					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			skin(1)	1			Epithelial(10;0.206)			CCAGCCCCCTCAGGGTCTCCT	0.657													8	18					0	0	0	0	T	30660370	T	T	30660370	2	4	261	1	0	0	0	0	0	0	0	1	11345	813	29	2		2	OSM	22	30660370	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5901120	30660370	20644196	484	47860											
APOL1	8542	broad.mit.edu	37	chr22	36661869	36661869	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaacccagcatcctggaaatGagcagaggagtcaagctcac	14	5	11	11	0	2	2	2	1	0	1	3	5	3	4	2	2	4	3	2	2	3	0			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:36661869G>C	uc003apf.2	+	6	1155	c.987G>C	c.(985-987)ATG>ATC	p.M329I	APOL1_uc011amn.1_Missense_Mutation_p.M206I|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Missense_Mutation_p.M345I|APOL1_uc011amo.1_Missense_Mutation_p.M206I|APOL1_uc011amp.1_Missense_Mutation_p.M329I|APOL1_uc011amq.1_Missense_Mutation_p.M311I|APOL1_uc010gwx.2_Missense_Mutation_p.M206I	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	329					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						TCCTGGAAATGAGCAGAGGAG	0.542													6	47					0	0	0	0	C	36661869	C	C	36661869	3	2	261	1	0	0	0	0	1	0	0	0	805	1290	45	2	1057	2	APOL1	22	36661869	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	6001499	36661869	14642697	485	47861											
EP300	2033	broad.mit.edu	37	chr22	41565529	41565529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtatacatatcttacctcGatagtgttcatttcttccgt	9	17	6	9	2	3	0	1	0	2	0	5	2	4	0	2	0	2	2	2	0	5	8			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:41565529G>A	uc003azl.3	+	26	4590	c.4195G>A	c.(4195-4197)GAT>AAT	p.D1399N		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1399				D->Y: Does not interact with TFAP2A and inhibits transcriptional coactivation of TFAP2A by CITED2. Does not inhibit interaction with CITED2, DNA-binding of TFAP2A or nuclear localization of TFAP2A or CITED2.	apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.D1399Y(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ATCTTACCTCGATAGTGTTCA	0.338			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				13	55					0	0	0	0	A	41565529	A	A	41565529	3	1	261	1	0	0	0	0	1	0	0	0	5172	1058	37	1	4297	1	EP300	22	41565529	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4903660	41565529	9739037	486	47862											
PIM3	415116	broad.mit.edu	37	chr22	50356510	50356510	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcttccggaggagggtctctCcaggtgcgtggtggctcgag	4	10	17	10	3	2	0	0	0	2	0	6	3	4	2	2	6	1	1	2	6	0	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:50356510C>T	uc003bjb.2	+	5	1243	c.790C>T	c.(790-792)CCA>TCA	p.P264S	PIM3_uc011arj.1_Missense_Mutation_p.P27S	NM_001001852	NP_001001852	Q86V86	PIM3_HUMAN	serine/threonine protein kinase pim-3	264	Protein kinase.				cell cycle|negative regulation of apoptosis|regulation of mitotic cell cycle		ATP binding|protein binding|protein serine/threonine kinase activity				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.196)|LUAD - Lung adenocarcinoma(64;0.247)		GAGGGTCTCTCCAGGTGCGTG	0.682													8	25					0	0	0	0	T	50356510	T	T	50356510	3	4	261	1	0	0	0	0	1	0	0	0	11984	855	30	2	808	2	PIM3	22	50356510	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	8790981	50356510	948056	487	47863											
TUBGCP6	85378	broad.mit.edu	37	chr22	50656779	50656779	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgctgcatctcgtgcttGaacagctgcagctgacggaa	11	9	11	10	2	1	2	0	2	1	0	2	3	1	3	0	1	7	6	0	1	3	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:50656779G>C	uc003bkb.1	-	23	5519	c.5007C>G	c.(5005-5007)TTC>TTG	p.F1669L	TUBGCP6_uc003bka.1_Missense_Mutation_p.Q746E|TUBGCP6_uc010har.1_Missense_Mutation_p.F1661L|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1669					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCTCGTGCTTGAACAGCTGCA	0.632													12	36					0	0	0	0	C	50656779	C	C	50656779	3	2	261	1	0	0	0	0	1	0	0	0	16838	1281	45	2	464	2	TUBGCP6	22	50656779	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	300269	50656779	647787	488	47864											
PLXNB2	23654	broad.mit.edu	37	chr22	50724643	50724643	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggcctggcggcagtcgtaGaaggggtactggtaggacgt	8	8	18	7	3	0	1	0	0	0	1	1	2	0	2	1	7	1	4	1	7	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:50724643G>C	uc003bkv.3	-	9	1942	c.1836C>G	c.(1834-1836)TTC>TTG	p.F612L		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	612	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGCAGTCGTAGAAGGGGTACT	0.627													28	79					0	0	0	0	C	50724643	C	C	50724643	3	2	261	1	0	0	0	0	1	0	0	0	12179	933	33	2	3796	2	PLXNB2	22	50724643	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	67864	50724643	579923	489	47865											
ARHGAP6	395	broad.mit.edu	37	chrX	11187648	11187648	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacagggcttcataattttCaatcatcttttgcacaacag	13	13	6	9	0	4	0	3	0	1	0	4	1	4	0	0	1	3	2	0	1	4	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:11187648C>T	uc004cup.1	-	9	2659	c.1786G>A	c.(1786-1788)GAA>AAA	p.E596K	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.E596K|ARHGAP6_uc004cum.1_Missense_Mutation_p.E393K|ARHGAP6_uc004cun.1_Missense_Mutation_p.E416K|ARHGAP6_uc010neb.1_Missense_Mutation_p.E418K|ARHGAP6_uc011mif.1_Missense_Mutation_p.E393K	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	596	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						TCATAATTTTCAATCATCTTT	0.488													14	45					0	0	0	0	T	11187648	T	T	11187648	3	4	261	1	0	0	0	0	1	0	0	0	887	835	29	2	1280	2	ARHGAP6	23	11187648	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08		11187648	144082912	490	47866											
PRPS2	5634	broad.mit.edu	37	chrX	12837668	12837668	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaatgtggaatttgctttGatccacaaagagaggaagaa	15	11	11	4	0	0	4	0	2	0	2	1	7	1	6	1	2	1	1	1	2	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:12837668G>C	uc004cvb.2	+	5	697	c.573G>C	c.(571-573)TTG>TTC	p.L191F	PRPS2_uc004cva.2_Missense_Mutation_p.L194F|PRPS2_uc010nec.2_Intron	NM_002765	NP_002756	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	191					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity				0						AATTTGCTTTGATCCACAAAG	0.488													36	120					0	0	0	0	C	12837668	C	C	12837668	3	2	261	1	0	0	0	0	1	0	0	0	12642	1281	45	2	600	2	PRPS2	23	12837668	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1650020	12837668	142432892	491	47867											
DMD	1756	broad.mit.edu	37	chrX	31986604	31986604	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgttctgacaacagtttGccgctgcccaatgccatcct	9	11	7	14	1	1	1	0	1	1	0	2	1	2	1	4	0	4	3	4	0	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:31986604G>T	uc004dda.1	-	45	6710	c.6466C>A	c.(6466-6468)CAA>AAA	p.Q2156K	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.Q812K|DMD_uc004dcx.2_Missense_Mutation_p.Q815K|DMD_uc004dcz.2_Missense_Mutation_p.Q2033K|DMD_uc004dcy.1_Missense_Mutation_p.Q2152K|DMD_uc004ddb.1_Missense_Mutation_p.Q2148K|DMD_uc010ngo.1_Missense_Mutation_p.Q65K|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2156	Spectrin 15.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ACAACAGTTTGCCGCTGCCCA	0.393													20	53					1.37657e-19	1.49272e-19	1	0	T	31986604	T	T	31986604	3	4	261	1	0	0	0	0	1	0	0	0	4602	1328	46	4	4879	4	DMD	23	31986604	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	19148936	31986604	123283956	492	47868											
SYTL5	94122	broad.mit.edu	37	chrX	37969686	37969686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtagagattccttttgactCatggaactttgaaaatccaa	14	13	7	7	0	1	3	1	2	0	1	3	5	3	4	2	1	1	1	2	1	5	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:37969686C>T	uc004ddu.2	+	14	2081	c.1547C>T	c.(1546-1548)TCA>TTA	p.S516L	SYTL5_uc004ddv.2_Missense_Mutation_p.S516L|SYTL5_uc004ddx.2_Missense_Mutation_p.S538L	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	516					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						CCTTTTGACTCATGGAACTTT	0.438													18	113					0	0	0	0	T	37969686	T	T	37969686	3	4	261	1	0	0	0	0	1	0	0	0	15552	838	29	2	1663	2	SYTL5	23	37969686	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	5983082	37969686	117300874	493	47869											
PAGE5	90737	broad.mit.edu	37	chrX	55247872	55247872	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaggaaatgaccaagagtcTtcccagccagttggacctgt	12	8	11	10	0	1	3	0	1	1	2	2	5	2	5	4	2	1	1	4	2	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:55247872T>C	uc004duj.2	+	2	359	c.117T>C	c.(115-117)TCT>TCC	p.S39S	PAGE5_uc004duk.2_Silent_p.S19S	NM_130467	NP_569734	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 isoform 1	39											0						ACCAAGAGTCTTCCCAGCCAG	0.348													25	53					0	0	0	0	C	55247872	C	C	55247872	2	2	261	1	0	0	0	0	0	0	0	1	11447	1596	56	5		5	PAGE5	23	55247872	Silent	SNP	T	TCGA-CV-7427-01A-11D-2078-08	17278186	55247872	100022688	494	47870											
SPIN4	139886	broad.mit.edu	37	chrX	62570191	62570191	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagtcaccatctttgtagtCatcaagcagcgtgtacatat	12	13	7	9	1	4	0	3	0	1	0	4	0	4	0	1	0	3	3	1	0	5	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:62570191C>T	uc004dvf.2	-	1	1028	c.508G>A	c.(508-510)GAC>AAC	p.D170N		NM_001012968	NP_001012986	Q56A73	SPIN4_HUMAN	spindlin family, member 4	170					gamete generation					ovary(1)|lung(1)	2						TCTTTGTAGTCATCAAGCAGC	0.478													25	91					0	0	0	0	T	62570191	T	T	62570191	3	4	261	1	0	0	0	0	1	0	0	0	15122	826	29	2	245	2	SPIN4	23	62570191	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	7322319	62570191	92700369	495	47871											
LPAR4	2846	broad.mit.edu	37	chrX	78010707	78010707	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacaccctctgcaagatctCtggaactgcattccttacca	10	11	6	14	0	2	2	0	1	2	1	4	3	3	3	3	1	4	2	3	1	3	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:78010707C>G	uc010nme.2	+	2	746	c.341C>G	c.(340-342)TCT>TGT	p.S114C		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	114	Helical; Name=3; (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						TGCAAGATCTCTGGAACTGCA	0.433													27	121					0	0	0	0	G	78010707	G	G	78010707	3	3	261	1	0	0	0	0	1	0	0	0	8957	913	32	2	343	2	LPAR4	23	78010707	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	15440516	78010707	77259853	496	47872											
P2RY10	27334	broad.mit.edu	37	chrX	78216233	78216233	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaataaagccatcattttCatgatcaacctctctgtggc	14	12	5	10	0	4	1	3	1	1	0	5	1	4	1	2	1	2	0	2	1	5	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:78216233C>G	uc004ede.2	+	4	585	c.216C>G	c.(214-216)TTC>TTG	p.F72L	P2RY10_uc004edf.2_Missense_Mutation_p.F72L	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	72	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CCATCATTTTCATGATCAACC	0.458													12	101					0	0	0	0	G	78216233	G	G	78216233	3	3	261	1	0	0	0	0	1	0	0	0	11401	825	29	2	218	2	P2RY10	23	78216233	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	205526	78216233	77054327	497	47873											
NAP1L3	4675	broad.mit.edu	37	chrX	92928297	92928297	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaccattttaaaatctgcttCtgccatcttgcaagcctaca	11	13	5	12	0	3	0	0	0	3	0	3	1	3	0	3	0	5	2	3	0	4	5			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:92928297C>G	uc004efq.2	-	1	312	c.7G>C	c.(7-9)GAA>CAA	p.E3Q	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	3					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						AAATCTGCTTCTGCCATCTTG	0.453													17	55					0	0	0	0	G	92928297	G	G	92928297	3	3	261	1	0	0	0	0	1	0	0	0	10211	922	32	2	1517	2	NAP1L3	23	92928297	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	14712064	92928297	62342263	498	47874											
CENPI	2491	broad.mit.edu	37	chrX	100382652	100382652	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacagaacatccattgcttaGaggtatgtgactggaccatg	12	11	10	8	0	0	3	0	1	0	2	1	4	1	4	2	2	3	2	2	2	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:100382652G>C	uc004egx.2	+	10	1342	c.1072G>C	c.(1072-1074)GAG>CAG	p.E358Q	CENPI_uc011mrg.1_Missense_Mutation_p.E358Q|CENPI_uc004egy.2_Missense_Mutation_p.E358Q	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	358					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						CCATTGCTTAGAGGTATGTGA	0.299													41	103					0	0	0	0	C	100382652	C	C	100382652	3	2	261	1	0	0	0	0	1	0	0	0	3248	943	33	2	1106	2	CENPI	23	100382652	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	7454355	100382652	54887908	499	47875											
DRP2	1821	broad.mit.edu	37	chrX	100505953	100505953	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccagttcctggagtgggtCaacctggagccccagtccat	7	9	11	14	0	1	0	1	0	0	0	4	2	4	2	6	3	2	1	6	3	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:100505953C>T	uc004egz.2	+	16	2115	c.1746C>T	c.(1744-1746)GTC>GTT	p.V582V	DRP2_uc011mrh.1_Silent_p.V504V	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	582					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						TGGAGTGGGTCAACCTGGAGC	0.537													23	98					0	0	0	0	T	100505953	T	T	100505953	2	4	261	1	0	0	0	0	0	0	0	1	4786	813	29	2		2	DRP2	23	100505953	Silent	SNP	C	TCGA-CV-7427-01A-11D-2078-08	123301	100505953	54764607	500	47876											
ARMCX2	9823	broad.mit.edu	37	chrX	100911314	100911314	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caatttgcggattgtctcttGattgcatgaataattggcat	10	16	9	6	1	1	2	0	2	1	0	2	3	1	3	0	2	2	2	0	2	3	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:100911314G>A	uc004eid.2	-	3	1616	c.1261C>T	c.(1261-1263)CAA>TAA	p.Q421*	ARMCX2_uc004eie.3_Nonsense_Mutation_p.Q421*|ARMCX2_uc004eif.3_Nonsense_Mutation_p.Q421*|ARMCX2_uc004eig.3_Nonsense_Mutation_p.Q421*|ARMCX2_uc010nnt.2_Nonsense_Mutation_p.Q421*	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	421	ARM 2.					integral to membrane	binding			ovary(6)	6						ATTGTCTCTTGATTGCATGAA	0.413													20	68					0	0	0	0	A	100911314	A	A	100911314	4	1	261	1	0	0	0	0	0	1	0	0	962	1299	45	2	641	2	ARMCX2	23	100911314	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	405361	100911314	54359246	501	47877											
BHLHB9	80823	broad.mit.edu	37	chrX	102004986	102004986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgggtgtccataatgttcacCcatttgcccaagagtttatt	9	15	8	9	0	1	1	1	0	0	1	2	1	2	1	3	1	1	2	3	1	3	6			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:102004986C>T	uc010nog.2	+	4	1634	c.1063C>T	c.(1063-1065)CCA>TCA	p.P355S	BHLHB9_uc011mrq.1_Missense_Mutation_p.P355S|BHLHB9_uc011mrr.1_Missense_Mutation_p.P355S|BHLHB9_uc011mrs.1_Missense_Mutation_p.P355S|BHLHB9_uc011mrt.1_Missense_Mutation_p.P355S|BHLHB9_uc004ejo.2_Missense_Mutation_p.P355S|BHLHB9_uc011mru.1_Missense_Mutation_p.P355S|BHLHB9_uc011mrv.1_Missense_Mutation_p.P355S	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	355						cytoplasm|nucleus	binding			ovary(2)	2						TAATGTTCACCCATTTGCCCA	0.363													5	73					0	0	0	0	T	102004986	T	T	102004986	3	4	261	1	0	0	0	0	1	0	0	0	1423	623	22	4	1065	4	BHLHB9	23	102004986	Missense_Mutation	SNP	C	TCGA-CV-7427-01A-11D-2078-08	1093672	102004986	53265574	502	47878											
ESX1	80712	broad.mit.edu	37	chrX	103498857	103498857	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgccacaacgtcgggatattGagattcatcgaaaaagttct	13	10	9	9	4	2	1	1	1	1	1	4	4	2	2	1	1	1	1	1	1	4	4			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:103498857G>A	uc004ely.2	-	2	542	c.484C>T	c.(484-486)CAA>TAA	p.Q162*		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	162	Homeobox.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCGGGATATTGAGATTCATCG	0.612													22	70					0	0	0	0	A	103498857	A	A	103498857	4	1	261	1	0	0	0	0	0	1	0	0	5287	1299	45	2	748	2	ESX1	23	103498857	Nonsense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1493871	103498857	51771703	503	47879											
IRS4	8471	broad.mit.edu	37	chrX	107976960	107976960	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatctgaaggctttgaaggtGatcccccatctccaggcttt	8	12	10	11	0	2	3	0	3	2	0	4	4	3	3	3	3	0	2	3	3	2	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:107976960G>A	uc004eoc.2	-	1	2648	c.2615C>T	c.(2614-2616)TCA>TTA	p.S872L		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	872						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTTTGAAGGTGATCCCCCATC	0.443													58	201					0	0	0	0	A	107976960	A	A	107976960	3	1	261	1	0	0	0	0	1	0	0	0	7881	1294	45	2	1162	2	IRS4	23	107976960	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	4478103	107976960	47293600	504	47880											
IRS4	8471	broad.mit.edu	37	chrX	107976981	107976981	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcccccatctccaggctttGagaatgatccctcacctgaa	10	10	6	15	0	2	3	1	3	1	1	5	4	4	3	5	1	0	1	5	1	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:107976981G>A	uc004eoc.2	-	1	2627	c.2594C>T	c.(2593-2595)TCA>TTA	p.S865L		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	865						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						TCCAGGCTTTGAGAATGATCC	0.468													60	212					0	0	0	0	A	107976981	A	A	107976981	3	1	261	1	0	0	0	0	1	0	0	0	7881	1294	45	2	1183	2	IRS4	23	107976981	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	21	107976981	47293579	505	47881											
WDR44	54521	broad.mit.edu	37	chrX	117526862	117526862	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacctgtgagaaaccagtaGatgaaaccacgaagttaact	18	7	8	8	1	0	3	0	2	0	2	0	5	0	3	3	0	4	2	3	0	6	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:117526862G>C	uc004eqn.2	+	4	879	c.454G>C	c.(454-456)GAT>CAT	p.D152H	WDR44_uc004eqo.2_Missense_Mutation_p.D152H|WDR44_uc011mtr.1_Missense_Mutation_p.D127H|WDR44_uc010nqi.2_5'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	152	Potential.|Binding activity.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						GAAACCAGTAGATGAAACCAC	0.378													25	91					0	0	0	0	C	117526862	C	C	117526862	3	2	261	1	0	0	0	0	1	0	0	0	17364	942	33	2	468	2	WDR44	23	117526862	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	9549881	117526862	37743698	506	47882											
SASH3	54440	broad.mit.edu	37	chrX	128926786	128926786	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaagcctaagaccctgcatGagctgctggagcgcatcggc	9	6	12	14	2	0	2	0	1	0	1	1	3	0	3	3	2	5	4	3	2	2	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:128926786G>A	uc011mun.1	+	6	957	c.775G>A	c.(775-777)GAG>AAG	p.E259K	SASH3_uc004euu.2_Missense_Mutation_p.E259K|SASH3_uc011muo.1_Missense_Mutation_p.E226K	NM_018990	NP_061863	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	259	SAM.									ovary(2)|pancreas(1)	3						GACCCTGCATGAGCTGCTGGA	0.607													13	15					0	0	0	0	A	128926786	A	A	128926786	3	1	261	1	0	0	0	0	1	0	0	0	13914	1291	45	2	797	2	SASH3	23	128926786	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	11399924	128926786	26343774	507	47883											
GPR101	83550	broad.mit.edu	37	chrX	136113291	136113291	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccccccagatcatggagcaGagagcattgcgctcatcaaa	12	6	10	13	1	3	2	3	0	0	2	3	4	3	3	3	1	3	3	3	1	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:136113291G>C	uc011mwh.1	-	1	543	c.543C>G	c.(541-543)CTC>CTG	p.L181L		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	181	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					TCATGGAGCAGAGAGCATTGC	0.572													11	22					0	0	0	0	C	136113291	C	C	136113291	2	2	261	1	0	0	0	0	0	0	0	1	6660	929	33	2		2	GPR101	23	136113291	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	7186505	136113291	19157269	508	47884											
FMR1NB	158521	broad.mit.edu	37	chrX	147084799	147084799	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccaatctctggaagaagAttccgcattggaagctttgc	10	11	11	9	1	1	2	0	0	1	2	3	4	2	4	2	3	2	2	2	3	4	3			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:147084799A>T	uc004fcm.2	+	2	430	c.356A>T	c.(355-357)GAT>GTT	p.D119V		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	119	Extracellular (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CTGGAAGAAGATTCCGCATTG	0.353													26	62					0	0	0	0	T	147084799	T	T	147084799	3	4	261	1	0	0	0	0	1	0	0	0	5993	333	12	5	362	5	FMR1NB	23	147084799	Missense_Mutation	SNP	A	TCGA-CV-7427-01A-11D-2078-08	10971508	147084799	8185761	509	47885											
MAGEA8	4107	broad.mit.edu	37	chrX	149013285	149013285	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaccgacagcactctgtGgagccaatccgatgagggtt	9	9	12	11	2	2	1	1	1	1	0	3	4	3	2	3	2	2	2	3	2	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:149013285G>C	uc004fdw.1	+	3	454	c.239G>C	c.(238-240)TGG>TCG	p.W80S		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	80											0	Acute lymphoblastic leukemia(192;6.56e-05)					AGCACTCTGTGGAGCCAATCC	0.597													14	52					0	0	0	0	C	149013285	C	C	149013285	3	2	261	1	0	0	0	0	1	0	0	0	9222	1357	47	4	241	4	MAGEA8	23	149013285	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	1928486	149013285	6257275	510	47886											
ABCD1	215	broad.mit.edu	37	chrX	153006073	153006073	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtgaccaggtgatctacccGgactcagtggaggacatgca	10	7	13	11	2	2	2	1	2	1	0	2	5	2	5	2	4	2	1	2	4	1	1			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:153006073G>A	uc004fif.2	+	7	2079	c.1680G>A	c.(1678-1680)CCG>CCA	p.P560P	ABCD1_uc004fig.2_Silent_p.P60P|ABCD1_uc004fih.2_5'Flank	NM_000033	NP_000024	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member	560	ABC transporter.		P -> S (in X-ALD).|P -> L (in X-ALD; CALD-type).|P -> R (in X-ALD; AMN and ALMD-types).		fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGATCTACCCGGACTCAGTGG	0.637													15	54					0	0	0	0	A	153006073	A	A	153006073	2	1	261	1	0	0	0	0	0	0	0	1	60	1103	39	1		1	ABCD1	23	153006073	Silent	SNP	G	TCGA-CV-7427-01A-11D-2078-08	3992788	153006073	2264487	511	47887											
FAM50A	9130	broad.mit.edu	37	chrX	153677638	153677638	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccttcggaaagacttcagtGagctgaggtgtgaggtgtgc	8	11	15	7	1	1	4	1	3	0	1	3	5	2	5	1	3	2	1	1	3	1	2			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:153677638G>C	uc004fll.3	+	8	816	c.718G>C	c.(718-720)GAG>CAG	p.E240Q		NM_004699	NP_004690	Q14320	FA50A_HUMAN	XAP-5 protein	240					spermatogenesis	nucleus				ovary(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGACTTCAGTGAGCTGAGGTG	0.592													11	33					0	0	0	0	C	153677638	C	C	153677638	3	2	261	1	0	0	0	0	1	0	0	0	5609	1291	45	2	748	2	FAM50A	23	153677638	Missense_Mutation	SNP	G	TCGA-CV-7427-01A-11D-2078-08	671565	153677638	1592922	512	47888											
KIAA2013	90231	broad.mit.edu	37	chr1	11983424	11983424	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgactccatctggtctcgctCcctgtggctcagggaggggc	4	9	14	14	2	3	0	1	0	2	0	6	2	5	1	2	5	0	2	2	5	0	0			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr1:11983424C>T	uc001atk.2	-	2	1350	c.1156G>A	c.(1156-1158)GAG>AAG	p.E386K	KIAA2013_uc001atl.1_Missense_Mutation_p.E386K	NM_138346	NP_612355	Q8IYS2	K2013_HUMAN	hypothetical protein LOC90231 precursor	386	Extracellular (Potential).					integral to membrane				ovary(1)	1	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTCTCGCTCCCTGTGGCTC	0.637													5	75					0	0	0	0	T	11983424	T	T	11983424	3	4	262	1	0	0	0	0	1	0	0	0	8306	864	30	2	756	2	KIAA2013	1	11983424	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08		11983424	237267197	1	47889											
VPS13D	55187	broad.mit.edu	37	chr1	12304423	12304423	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatacaggatttcaatgAtgaaaaggagaagctgttgg	17	9	12	3	0	1	3	1	2	0	1	1	6	1	4	0	3	2	2	0	3	7	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr1:12304423A>G	uc001atv.2	+	4	437	c.296A>G	c.(295-297)GAT>GGT	p.D99G	VPS13D_uc001atw.2_Missense_Mutation_p.D99G	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	99					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GATTTCAATGATGAAAAGGAG	0.478													26	61					0	0	0	0	G	12304423	G	G	12304423	3	3	262	1	0	0	0	0	1	0	0	0	17260	333	12	5	306	5	VPS13D	1	12304423	Missense_Mutation	SNP	A	TCGA-CV-7429-01A-11D-2129-08	320999	12304423	236946198	2	47890											
RUNX3	864	broad.mit.edu	37	chr1	25245773	25245773	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacggtcaccttgatggctcGgtggtaggtcgccacttggg	5	10	15	11	3	1	1	1	1	0	0	3	1	1	1	2	6	0	2	2	6	1	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr1:25245773G>A	uc001bjq.2	-	3	913	c.502C>T	c.(502-504)CGA>TGA	p.R168*	RUNX3_uc010oen.1_Nonsense_Mutation_p.R168*|RUNX3_uc009vrj.2_Nonsense_Mutation_p.R182*|RUNX3_uc001bjr.2_Nonsense_Mutation_p.R182*	NM_004350	NP_004341	Q13761	RUNX3_HUMAN	runt-related transcription factor 3 isoform 2	168	Runt.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		TTGATGGCTCGGTGGTAGGTC	0.652													10	62					0	0	0	0	A	25245773	A	A	25245773	4	1	262	1	0	0	0	0	0	1	0	0	13814	1124	39	1	757	1	RUNX3	1	25245773	Nonsense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	12941350	25245773	224004848	3	47891											
ARID1A	8289	broad.mit.edu	37	chr1	27088729	27088729	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgtcagccttccggaggaCagatacacacaggcatgggc	10	5	13	13	3	1	1	1	0	0	1	2	3	2	3	2	4	2	1	2	4	1	2			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr1:27088729C>T	uc001bmv.1	+	7	2711	c.2338C>T	c.(2338-2340)CAG>TAG	p.Q780*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q780*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q780*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q397*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	780					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TTCCGGAGGACAGATACACAC	0.577			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								22	70					0	0	0	0	T	27088729	T	T	27088729	4	4	262	1	0	0	0	0	0	1	0	0	913	479	17	4	2364	4	ARID1A	1	27088729	Nonsense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08	1842956	27088729	222161892	4	47892											
INADL	10207	broad.mit.edu	37	chr1	62321821	62321821	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtctcagtcaatgaatactgTttggacaacacctcacttgc	11	12	7	11	0	3	1	3	1	1	0	4	2	3	2	1	1	3	1	1	1	4	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr1:62321821T>C	uc001dab.2	+	18	2346	c.2232T>C	c.(2230-2232)TGT>TGC	p.C744C	INADL_uc009waf.1_Silent_p.C744C|INADL_uc001daa.2_Silent_p.C744C|INADL_uc001dad.3_Silent_p.C441C|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	744	PDZ 5.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						ATGAATACTGTTTGGACAACA	0.493													42	76					0	0	0	0	C	62321821	C	C	62321821	2	2	262	1	0	0	0	0	0	0	0	1	7770	1731	60	5		5	INADL	1	62321821	Silent	SNP	T	TCGA-CV-7429-01A-11D-2129-08	35233092	62321821	186928800	5	47893											
SASS6	163786	broad.mit.edu	37	chr1	100550935	100550935	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgaagacgcagaggggagCgctgtgggtttggaagatgt	9	8	19	5	2	0	4	0	1	0	3	0	6	0	6	0	4	1	4	0	4	2	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr1:100550935C>T	uc001dsu.2	-	17	2064	c.1923G>A	c.(1921-1923)GCG>GCA	p.A641A	SASS6_uc009wdz.2_Silent_p.A474A	NM_194292	NP_919268	Q6UVJ0	SAS6_HUMAN	spindle assembly abnormal protein 6	641					centriole replication	centriole				upper_aerodigestive_tract(1)|ovary(1)	2		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		CAGAGGGGAGCGCTGTGGGTT	0.408													54	117					0	0	0	0	T	100550935	T	T	100550935	2	4	262	1	0	0	0	0	0	0	0	1	13915	755	27	1		1	SASS6	1	100550935	Silent	SNP	C	TCGA-CV-7429-01A-11D-2129-08	38229114	100550935	148699686	6	47894											
FLAD1	80308	broad.mit.edu	37	chr1	154962992	154962992	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcccgcattcatgcgcatCaacccactgctggtaatggg	8	9	11	13	2	2	0	2	0	0	0	2	0	2	0	2	3	3	4	2	3	2	2			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr1:154962992C>T	uc001fgf.1	+	5	1896	c.1542C>T	c.(1540-1542)ATC>ATT	p.I514I	FLAD1_uc001fgd.1_3'UTR|FLAD1_uc001fge.1_Silent_p.I417I|FLAD1_uc001fgg.1_Silent_p.I417I|FLAD1_uc001fgh.1_Intron	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	514	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TCATGCGCATCAACCCACTGC	0.607													7	28					0	0	0	0	T	154962992	T	T	154962992	2	4	262	1	0	0	0	0	0	0	0	1	5952	816	29	2		2	FLAD1	1	154962992	Silent	SNP	C	TCGA-CV-7429-01A-11D-2129-08	54412057	154962992	94287629	7	47895											
TMCO1	54499	broad.mit.edu	37	chr1	165721337	165721337	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcatataaaaggacactcAcatggaattgaacattccca	18	8	6	9	0	1	1	1	1	0	0	2	3	2	3	1	2	2	1	1	2	6	4			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr1:165721337A>G	uc001gdj.3	-	5	472	c.323_splice	c.e5+1	p.I108_splice	TMCO1_uc001gdl.3_Splice_Site_p.I24_splice|TMCO1_uc001gdm.3_Splice_Site_p.I24_splice|TMCO1_uc001gdk.3_Splice_Site_p.I96_splice|TMCO1_uc001gdn.3_Splice_Site	NM_019026	NP_061899	Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1							endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					AAGGACACTCACATGGAATTG	0.274													5	62					0	0	0	0	G	165721337	G	G	165721337	5	3	262	1	0	0	0	0	0	0	1	0	16061	173	6	5	253	5	TMCO1	1	165721337	Splice_Site	SNP	A	TCGA-CV-7429-01A-11D-2129-08	10758345	165721337	83529284	8	47896											
C1orf35	79169	broad.mit.edu	37	chr1	228288911	228288911	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtccccgcttcctcctcttaCagcagggggagttggagtcg	5	10	13	13	2	1	0	0	0	1	0	5	2	4	2	4	3	2	3	4	3	1	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr1:228288911C>A	uc001hrx.2	-	8	807	c.713G>T	c.(712-714)TGT>TTT	p.C238F	C1orf35_uc009xew.2_RNA	NM_024319	NP_077295	Q9BU76	MMTA2_HUMAN	hypothetical protein LOC79169	238											0		Prostate(94;0.0488)				CCTCCTCTTACAGCAGGGGGA	0.647													28	25					2.48779e-11	2.82859e-11	1	0	A	228288911	A	A	228288911	3	1	262	1	0	0	0	0	1	0	0	0	2048	478	17	4	82	4	C1orf35	1	228288911	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08	62567574	228288911	20961710	9	47897											
OR2L13	284521	broad.mit.edu	37	chr1	248262831	248262831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcacctcatccacgtggatCctcgtctccacacaccgatg	8	10	6	17	3	3	0	2	0	1	0	7	2	5	1	5	1	0	0	5	1	0	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr1:248262831C>T	uc001ids.2	+	3	491	c.154C>T	c.(154-156)CCT>TCT	p.P52S		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CCACGTGGATCCTCGTCTCCA	0.498													17	137					0	0	0	0	T	248262831	T	T	248262831	3	4	262	1	0	0	0	0	1	0	0	0	11060	855	30	2	156	2	OR2L13	1	248262831	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08	19973920	248262831	987790	10	47898											
NFE2L2	4780	broad.mit.edu	37	chr2	178098804	178098804	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaattgggagaaattcacCtgtctcttcatctagttgta	10	15	8	8	0	4	2	2	1	2	1	5	3	4	2	1	1	0	2	1	1	4	6			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr2:178098804C>A	uc002ulh.3	-	2	796	c.241G>T	c.(241-243)GGT>TGT	p.G81C	NFE2L2_uc002ulg.3_Missense_Mutation_p.G65C|NFE2L2_uc010zfa.1_Missense_Mutation_p.G65C|NFE2L2_uc002uli.3_Missense_Mutation_p.G65C|NFE2L2_uc010fra.2_Missense_Mutation_p.G65C|NFE2L2_uc010frb.2_Missense_Mutation_p.G65C	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	81					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AGAAATTCACCTGTCTCTTCA	0.438			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			46	68					1.42923e-14	1.69466e-14	1	0	A	178098804	A	A	178098804	3	1	262	1	0	0	0	0	1	0	0	0	10422	681	24	4	1592	4	NFE2L2	2	178098804	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08		178098804	65100569	11	47899											
TTN	7273	broad.mit.edu	37	chr2	179600758	179600758	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccttacccacaaaagtTgtaagggacttaggtctgga	11	10	11	9	0	1	0	0	0	1	0	1	2	1	2	2	3	2	3	2	3	5	4			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr2:179600758T>C	uc010zfg.1	-	47	10907	c.10683A>G	c.(10681-10683)ACA>ACG	p.T3561T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T222T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4488							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACAAAAGTTGTAAGGGACT	0.458													25	54					0	0	0	0	C	179600758	C	C	179600758	2	2	262	1	0	0	0	0	0	0	0	1	16803	1799	63	5		5	TTN	2	179600758	Silent	SNP	T	TCGA-CV-7429-01A-11D-2129-08	1501954	179600758	63598615	12	47900											
SP140	11262	broad.mit.edu	37	chr2	231155199	231155199	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagaaagcacaaagatgaaaCtgtggattttaaggctcctt	16	10	9	6	0	0	3	0	1	0	2	1	4	1	4	1	2	2	2	1	2	5	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr2:231155199C>A	uc002vql.2	+	19	1860	c.1745C>A	c.(1744-1746)ACT>AAT	p.T582N	SP140_uc010zma.1_RNA|SP140_uc002vqn.2_Missense_Mutation_p.T468N|SP140_uc002vqm.2_Missense_Mutation_p.T522N|SP140_uc010fxl.2_Missense_Mutation_p.T555N	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	582	SAND.				defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AAAGATGAAACTGTGGATTTT	0.428													34	104					4.02929e-09	4.51934e-09	1	0	A	231155199	A	A	231155199	3	1	262	1	0	0	0	0	1	0	0	0	15026	565	20	4	1936	4	SP140	2	231155199	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08	51554441	231155199	12044174	13	47901											
TMEM207	131920	broad.mit.edu	37	chr3	190158157	190158157	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacagagaagagctgccacCaaaaccagcagcaggaggat	16	2	11	12	0	0	2	0	0	0	2	0	5	0	4	4	2	5	3	4	2	3	0			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr3:190158157C>A	uc003fsj.2	-	4	247	c.180G>T	c.(178-180)TTG>TTT	p.L60F		NM_207316	NP_997199	Q6UWW9	TM207_HUMAN	transmembrane protein 207 precursor	60	Helical; (Potential).					integral to membrane					0	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.0176)		GAGCTGCCACCAAAACCAGCA	0.517													9	32					0.000274275	0.000288162	1	0	A	190158157	A	A	190158157	3	1	262	1	0	0	0	0	1	0	0	0	16198	593	21	4	268	4	TMEM207	3	190158157	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08		190158157	7864273	14	47902											
UGT2B7	7364	broad.mit.edu	37	chr4	69962247	69962247	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattgcaccaggatgtctgtGaaatggacttcagtaatttt	11	14	9	7	0	2	1	1	1	1	0	2	3	2	3	1	2	1	2	1	2	2	5			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr4:69962247G>A	uc003heg.3	+	1	55	c.9G>A	c.(7-9)GTG>GTA	p.V3V	UGT2B7_uc010ihq.2_Silent_p.V3V	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	3					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GGATGTCTGTGAAATGGACTT	0.408													15	77					0	0	0	0	A	69962247	A	A	69962247	2	1	262	1	0	0	0	0	0	0	0	1	17030	1277	45	2		2	UGT2B7	4	69962247	Silent	SNP	G	TCGA-CV-7429-01A-11D-2129-08		69962247	121192029	15	47903											
FSTL5	56884	broad.mit.edu	37	chr4	162307374	162307374	+	Frame_Shift_Del	DEL	T	-	-																															gagtgcccgtcacatcactaTtgaacccaatgactgagtca																										TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr4:162307374delT	uc003iqh.2	-	16	2505	c.2069delA	c.(2068-2070)AATfs	p.N690fs	FSTL5_uc003iqi.2_Frame_Shift_Del_p.N689fs|FSTL5_uc010iqv.2_Frame_Shift_Del_p.N680fs|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	690						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CACATCACTATTGAACCCAAT	0.488													---	---	---								-	162307374	-	-	162307374	7	5	262	1	0	1	0	1	0	0	0	0	6114	1493	52	0	478	0	FSTL5	4	162307374	Frame_Shift_Del	DEL	T	TCGA-CV-7429-01A-11D-2129-08	92345127	162307374	28846902	16	47904											
SAP30L	79685	broad.mit.edu	37	chr5	153826344	153826344	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatctcgcagaagaaactCaagctggacatcgacaagag	16	5	10	10	2	2	3	1	0	1	3	4	5	2	4	0	1	3	3	0	1	4	0			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr5:153826344C>A	uc003lvk.2	+	1	828	c.180C>A	c.(178-180)CTC>CTA	p.L60L	uc003lvi.2_5'Flank|SAP30L_uc003lvm.3_RNA|SAP30L_uc011ddc.1_Silent_p.L60L|SAP30L_uc011ddd.1_Silent_p.L60L	NM_024632	NP_078908	Q9HAJ7	SP30L_HUMAN	SAP30-like isoform 1	60	Atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|metal ion binding				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			AGAAGAAACTCAAGCTGGACA	0.687													5	12					1.23904e-05	1.33559e-05	1	0	A	153826344	A	A	153826344	2	1	262	1	0	0	0	0	0	0	0	1	13900	813	29	2		2	SAP30L	5	153826344	Silent	SNP	C	TCGA-CV-7429-01A-11D-2129-08		153826344	27088916	17	47905											
HIST1H2BL	8340	broad.mit.edu	37	chr6	27775637	27775638	+	Frame_Shift_Ins	INS	-	TT	TT																															gggccttggtcaccgccttcINSttggagcccttcttcggggc																										TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr6:27775637_27775638insTT	uc003njl.2	-	1	72_73	c.47_48insAA	c.(46-48)AAGfs	p.K16fs	HIST1H3H_uc003njm.2_5'Flank	NM_003519	NP_003510	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	16					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TCACCGCCTTCTTGGAGCCCTT	0.54													---	---	---								TT	27775638	TT	TT	27775637	7	5	262	1	0	1	1	0	0	0	0	0	7190	912	32	0	336	0	HIST1H2BL	6	27775637	Frame_Shift_Ins	INS	-	TCGA-CV-7429-01A-11D-2129-08		27775637	143339430	18	47906											
KLHL31	401265	broad.mit.edu	37	chr6	53519325	53519325	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaaaagatctgcagcgtatTttactctcttttggtcaaat	11	16	6	8	1	4	1	2	0	2	1	5	1	4	1	0	1	3	2	0	1	5	5			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr6:53519325T>C	uc003pcb.3	-	2	887	c.746A>G	c.(745-747)AAA>AGA	p.K249R		NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	249	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					TGCAGCGTATTTTACTCTCTT	0.373													26	97					0	0	0	0	C	53519325	C	C	53519325	3	2	262	1	0	0	0	0	1	0	0	0	8424	1841	64	5	1166	5	KLHL31	6	53519325	Missense_Mutation	SNP	T	TCGA-CV-7429-01A-11D-2129-08	25743688	53519325	117595742	19	47907											
HS3ST5	222537	broad.mit.edu	37	chr6	114379002	114379002	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaatatgctgggctcttttCaattgtgatttgctgagggt	9	16	11	5	0	2	2	1	2	1	0	2	2	2	2	0	2	2	3	0	2	4	5			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr6:114379002C>G	uc003pwg.3	-	2	492	c.460G>C	c.(460-462)GAA>CAA	p.E154Q	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.E154Q	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	154	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GGGCTCTTTTCAATTGTGATT	0.383													29	145					0	0	0	0	G	114379002	G	G	114379002	3	3	262	1	0	0	0	0	1	0	0	0	7407	835	29	2	584	2	HS3ST5	6	114379002	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08	60859677	114379002	56736065	20	47908											
QKI	9444	broad.mit.edu	37	chr6	163956139	163956139	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagcagttgaagaagtgaaGaaattattggtacctgcagt	15	10	12	4	0	0	5	0	2	0	3	0	5	0	5	1	1	3	4	1	1	6	4			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr6:163956139G>T	uc003qui.2	+	4	1079	c.528G>T	c.(526-528)AAG>AAT	p.K176N	QKI_uc003que.2_Missense_Mutation_p.K176N|QKI_uc003quf.2_Missense_Mutation_p.K176N|QKI_uc003qug.2_Missense_Mutation_p.K176N|QKI_uc003quh.2_Missense_Mutation_p.K176N|QKI_uc003quj.2_Missense_Mutation_p.K176N	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	176					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		AAGAAGTGAAGAAATTATTGG	0.343													24	96					1.75199e-13	2.0481e-13	1	0	T	163956139	T	T	163956139	3	4	262	1	0	0	0	0	1	0	0	0	12938	933	33	2	542	2	QKI	6	163956139	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	49577137	163956139	7158928	21	47909											
HGF	3082	broad.mit.edu	37	chr7	81381502	81381502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attgcttgtgaaacaccaggGtcccccttcttcccctcgag	7	11	8	15	1	1	1	0	1	1	0	4	2	3	1	5	1	2	1	5	1	1	4			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr7:81381502G>A	uc003uhl.2	-	5	724	c.559C>T	c.(559-561)CCC>TCC	p.P187S	HGF_uc003uhm.2_Missense_Mutation_p.P182S|HGF_uc003uhn.1_Missense_Mutation_p.P187S|HGF_uc003uho.1_Missense_Mutation_p.P182S|HGF_uc003uhp.2_Missense_Mutation_p.P187S	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	187	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						AAACACCAGGGTCCCCCTTCT	0.443													8	31					0	0	0	0	A	81381502	A	A	81381502	3	1	262	1	0	0	0	0	1	0	0	0	7124	1261	44	4	1703	4	HGF	7	81381502	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08		81381502	77757161	22	47910											
PRKDC	5591	broad.mit.edu	37	chr8	48701554	48701555	+	Frame_Shift_Ins	INS	-	T	T																															tttcatacattttttcaatgINSttttttttatttacaggggt																										TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr8:48701554_48701555insT	uc003xqi.2	-	77	10871_10872	c.10814_10815insA	c.(10813-10815)AACfs	p.N3605fs	PRKDC_uc003xqj.2_Frame_Shift_Ins_p.N3605fs|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3605					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TTTTTTCAATGTTTTTTTTATT	0.401								NHEJ					---	---	---								T	48701555	T	T	48701554	7	5	262	1	0	1	1	0	0	0	0	0	12583	1368	48	0	1615	0	PRKDC	8	48701554	Frame_Shift_Ins	INS	-	TCGA-CV-7429-01A-11D-2129-08		48701554	97662468	23	47911											
ZFAT	57623	broad.mit.edu	37	chr8	135614165	135614165	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggaggaggtatcatttttCaacaaaaaatcatctgaaac	16	10	8	7	1	4	1	3	1	1	0	4	3	4	3	0	3	2	1	0	3	6	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr8:135614165C>A	uc003yup.2	-	6	1972	c.1797G>T	c.(1795-1797)TTG>TTT	p.L599F	ZFAT_uc003yun.2_Missense_Mutation_p.L587F|ZFAT_uc003yuo.2_Missense_Mutation_p.L587F|ZFAT_uc010meh.2_Missense_Mutation_p.L587F|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.L587F|ZFAT_uc010mej.2_Missense_Mutation_p.L537F|ZFAT_uc003yur.2_Missense_Mutation_p.L587F	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	599					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TATCATTTTTCAACAAAAAAT	0.537													9	37					1.12685e-05	1.23064e-05	1	0	A	135614165	A	A	135614165	3	1	262	1	0	0	0	0	1	0	0	0	17699	825	29	2	1978	2	ZFAT	8	135614165	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08	86912611	135614165	10749857	24	47912											
CDH23	64072	broad.mit.edu	37	chr10	73569779	73569779	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcggcttcgaggaggagttCatccacctgctctccaacat	8	9	10	14	3	2	0	1	0	1	0	5	3	3	2	3	3	2	3	3	3	1	2			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr10:73569779C>T	uc001jrx.3	+	59	9302	c.8925C>T	c.(8923-8925)TTC>TTT	p.F2975F	CDH23_uc001jsg.3_Silent_p.F735F|CDH23_uc001jsh.3_Silent_p.F735F|CDH23_uc001jsi.3_Silent_p.F735F|CDH23_uc001jsj.3_5'Flank|CDH23_uc010qjr.1_5'Flank	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2975	Cadherin 27.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						AGGAGGAGTTCATCCACCTGC	0.602													26	102					0	0	0	0	T	73569779	T	T	73569779	2	4	262	1	0	0	0	0	0	0	0	1	3123	825	29	2		2	CDH23	10	73569779	Silent	SNP	C	TCGA-CV-7429-01A-11D-2129-08		73569779	61964968	25	47913											
TAF5	6877	broad.mit.edu	37	chr10	105139408	105139408	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagaaattgaggtaccttTggatgacgaggatgaagagg	14	8	14	5	1	0	5	0	3	0	2	0	8	0	7	2	4	1	1	2	4	3	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr10:105139408T>G	uc001kwv.2	+	4	1180	c.1157T>G	c.(1156-1158)TTG>TGG	p.L386W	TAF5_uc010qqq.1_Missense_Mutation_p.L386W	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	386					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		GAGGTACCTTTGGATGACGAG	0.303													9	49					0	0	0	0	G	105139408	G	G	105139408	3	3	262	1	0	0	0	0	1	0	0	0	15594	1821	63	5	1171	5	TAF5	10	105139408	Missense_Mutation	SNP	T	TCGA-CV-7429-01A-11D-2129-08	31569629	105139408	30395339	26	47914											
CNGA4	1262	broad.mit.edu	37	chr11	6262969	6262969	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acagtatgctgtgctcggtgCagggctctactttggggaga	7	11	15	8	1	1	1	0	0	1	1	2	2	1	1	0	4	4	5	0	4	2	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr11:6262969C>A	uc001mco.2	+	5	1333	c.1226C>A	c.(1225-1227)GCA>GAA	p.A409E	CNGA4_uc010raa.1_Missense_Mutation_p.A178E|CNGA4_uc001mcn.2_Missense_Mutation_p.A369E	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	409	cNMP.|Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGCTCGGTGCAGGGCTCTAC	0.537													39	152					2.24893e-16	2.74502e-16	1	0	A	6262969	A	A	6262969	3	1	262	1	0	0	0	0	1	0	0	0	3614	710	25	4	1244	4	CNGA4	11	6262969	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08		6262969	128743547	27	47915											
USH1C	10083	broad.mit.edu	37	chr11	17548774	17548774	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctggcctcactcacgtctCactttgatggacacagtttt	7	14	7	13	1	4	1	3	1	2	0	5	2	4	2	1	2	0	1	1	2	0	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr11:17548774C>T	uc001mnf.2	-	5	601	c.492G>A	c.(490-492)GTG>GTA	p.V164V	USH1C_uc001mne.2_Silent_p.V164V|USH1C_uc009yhb.2_Silent_p.V164V|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Silent_p.V128V	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	164	PDZ 1.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						ACTCACGTCTCACTTTGATGG	0.353													19	65					0	0	0	0	T	17548774	T	T	17548774	2	4	262	1	0	0	0	0	0	0	0	1	17102	813	29	2		2	USH1C	11	17548774	Silent	SNP	C	TCGA-CV-7429-01A-11D-2129-08	11285805	17548774	117457742	28	47916											
FRMD8	83786	broad.mit.edu	37	chr11	65161133	65161133	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaccagtgccccagacgatGacgtggccatgggtcagtgc	8	7	13	13	2	2	2	2	1	0	1	2	3	2	2	4	2	2	0	4	2	0	0			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr11:65161133G>A	uc001odu.3	+	4	535	c.343G>A	c.(343-345)GAC>AAC	p.D115N	FRMD8_uc009yqj.2_Missense_Mutation_p.D59N|FRMD8_uc010rof.1_Intron	NM_031904	NP_114110	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	115	FERM.					cytoskeleton	binding			lung(1)|pancreas(1)	2						CCCAGACGATGACGTGGCCAT	0.652													5	24					0	0	0	0	A	65161133	A	A	65161133	3	1	262	1	0	0	0	0	1	0	0	0	6090	1290	45	2	353	2	FRMD8	11	65161133	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	47612359	65161133	69845383	29	47917											
EFEMP2	30008	broad.mit.edu	37	chr11	65635459	65635459	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgctccgaggtgatggtcAtgtagcggtgcacaatggat	8	10	14	9	3	1	1	1	1	0	0	3	3	3	2	2	4	2	3	2	4	2	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr11:65635459A>T	uc001ofy.3	-	10	1237	c.1043T>A	c.(1042-1044)ATG>AAG	p.M348K	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.M348K	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	348					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		GGTGATGGTCATGTAGCGGTG	0.612													5	86					0	0	0	0	T	65635459	T	T	65635459	3	4	262	1	0	0	0	0	1	0	0	0	4964	217	8	5	296	5	EFEMP2	11	65635459	Missense_Mutation	SNP	A	TCGA-CV-7429-01A-11D-2129-08	474326	65635459	69371057	30	47918											
ARHGEF12	23365	broad.mit.edu	37	chr11	120352148	120352148	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caatttcaccattcacccccGaatttctggtccagcagcgc	9	10	6	16	2	3	0	2	0	1	0	4	1	4	0	4	1	2	1	4	1	2	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr11:120352148G>A	uc001pxl.1	+	39	4424	c.4417G>A	c.(4417-4419)GAA>AAA	p.E1473K	ARHGEF12_uc009zau.1_Missense_Mutation_p.E1370K	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1473					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ATTCACCCCCGAATTTCTGGT	0.532			T	MLL	AML								22	65					0	0	0	0	A	120352148	A	A	120352148	3	1	262	1	0	0	0	0	1	0	0	0	897	1059	37	1	4571	1	ARHGEF12	11	120352148	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	54716689	120352148	14654368	31	47919											
RAPGEF3	10411	broad.mit.edu	37	chr12	48142708	48142708	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagccgcatggtctttgcctCcacatcctggagaacaggcc	8	8	10	15	1	1	1	0	0	1	1	3	2	3	1	5	3	3	1	5	3	1	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr12:48142708C>A	uc009zkp.2	-	10	1362	c.922G>T	c.(922-924)GAG>TAG	p.E308*	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Nonsense_Mutation_p.E308*|RAPGEF3_uc001rpz.3_Nonsense_Mutation_p.E350*|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Nonsense_Mutation_p.E362*	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	308					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GTCTTTGCCTCCACATCCTGG	0.592													30	93					3.99451e-17	4.94842e-17	1	0	A	48142708	A	A	48142708	4	1	262	1	0	0	0	0	0	1	0	0	13110	864	30	2	1795	2	RAPGEF3	12	48142708	Nonsense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08		48142708	85709187	32	47920											
GEFT	115557	broad.mit.edu	37	chr12	58008471	58008471	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaccctgtccctgtccccaGgagctccggcagcagctggg	5	6	12	18	1	0	0	0	0	0	0	3	1	3	1	6	3	3	4	6	3	0	0			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr12:58008471G>T	uc001spb.2	+	9	1277	c.817_splice	c.e9-1	p.E273_splice	GEFT_uc009zpy.2_Splice_Site_p.E312_splice|GEFT_uc001soz.1_Splice_Site_p.E147_splice|GEFT_uc001spa.2_Splice_Site_p.E167_splice|uc001spc.2_Intron|GEFT_uc001spd.2_Translation_Start_Site	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1						regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					CCTGTCCCCAGGAGCTCCGGC	0.587													4	35					0.00909568	0.00943677	1	0	T	58008471	T	T	58008471	5	4	262	1	0	0	0	0	0	0	1	0	6365	1014	35	4	1072	4	GEFT	12	58008471	Splice_Site	SNP	G	TCGA-CV-7429-01A-11D-2129-08	9865763	58008471	75843424	33	47921											
SART3	9733	broad.mit.edu	37	chr12	108917341	108917341	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcagggccgttctcagcctGaggagctgcagcacttgggc	6	7	16	12	1	1	1	1	1	1	0	2	2	1	2	2	4	4	5	2	4	0	2			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr12:108917341G>C	uc001tmz.1	-	19	3020	c.2785C>G	c.(2785-2787)CAG>GAG	p.Q929E	SART3_uc001tmy.1_Missense_Mutation_p.Q455E|SART3_uc009zux.1_Missense_Mutation_p.Q541E|SART3_uc010swx.1_Missense_Mutation_p.Q893E	NM_014706	NP_055521	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T	929					RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			pancreas(1)	1						TTCTCAGCCTGAGGAGCTGCA	0.602									Porokeratosis				34	84					0	0	0	0	C	108917341	C	C	108917341	3	2	262	1	0	0	0	0	1	0	0	0	13912	1299	45	2	110	2	SART3	12	108917341	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	50908870	108917341	24934554	34	47922											
ATXN2	6311	broad.mit.edu	37	chr12	111893892	111893892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggctgaacgtgagaaggatGgatcgtaaagacagtctgtt	12	9	14	6	3	1	3	0	2	1	2	2	6	1	5	0	3	1	3	0	3	4	2			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr12:111893892G>A	uc001tsj.2	-	23	3847	c.3685C>T	c.(3685-3687)CAT>TAT	p.H1229Y	ATXN2_uc001tsh.2_Missense_Mutation_p.H964Y|ATXN2_uc001tsi.2_Missense_Mutation_p.H922Y|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Missense_Mutation_p.H417Y|ATXN2_uc001tsl.1_Missense_Mutation_p.H230Y	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	1229					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						TGAGAAGGATGGATCGTAAAG	0.557													39	247					0	0	0	0	A	111893892	A	A	111893892	3	1	262	1	0	0	0	0	1	0	0	0	1213	1348	47	4	268	4	ATXN2	12	111893892	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	2976551	111893892	21958003	35	47923											
C12orf51	283450	broad.mit.edu	37	chr12	112667559	112667559	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctccaagtgcacacagtgcGgcaacggcctggcgtgcaat	9	6	12	14	3	0	0	0	0	0	0	1	0	1	0	3	3	4	3	3	3	3	0			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr12:112667559G>A	uc009zwc.2	-	34	5214	c.5196C>T	c.(5194-5196)GCC>GCT	p.A1732A	C12orf51_uc001ttr.1_5'Flank	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CACACAGTGCGGCAACGGCCT	0.493													40	119					0	0	0	0	A	112667559	A	A	112667559	2	1	262	1	0	0	0	0	0	0	0	1	1702	1103	39	1		1	C12orf51	12	112667559	Silent	SNP	G	TCGA-CV-7429-01A-11D-2129-08	773667	112667559	21184336	36	47924											
SOX1	6656	broad.mit.edu	37	chr13	112722100	112722100	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcggcggcggcggcggggGcgccaaggccaaccaggacc	6	0	21	14	6	0	0	0	0	0	0	0	1	0	1	4	9	1	0	4	9	2	0			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr13:112722100G>A	uc001vsb.1	+	1	188	c.128G>A	c.(127-129)GGC>GAC	p.G43D		NM_005986	NP_005977	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	43	Poly-Gly.				chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		ggcggcgggggcgCCAAGGCC	0.552													5	2					0	0	0	0	A	112722100	A	A	112722100	3	1	262	1	0	0	0	0	1	0	0	0	15004	1203	42	4	130	4	SOX1	13	112722100	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08		112722100	2447778	37	47925											
MTMR15	22909	broad.mit.edu	37	chr15	31197067	31197067	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgaaatgtgtgctaacaaTgacttcgttcaagtggatcc	12	12	10	7	1	1	2	1	2	0	0	3	4	2	3	1	1	2	2	1	1	4	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr15:31197067T>C	uc001zff.2	+	2	492	c.201T>C	c.(199-201)AAT>AAC	p.N67N	MTMR15_uc001zfc.3_Silent_p.N67N|MTMR15_uc010azw.2_Silent_p.N67N|MTMR15_uc001zfd.3_Silent_p.N67N|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	67	UBZ-type.				double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		GTGCTAACAATGACTTCGTTC	0.413								Direct_reversal_of_damage|Editing_and_processing_nucleases					19	51					0	0	0	0	C	31197067	C	C	31197067	2	2	262	1	0	0	0	0	0	0	0	1	9996	1461	51	5		5	MTMR15	15	31197067	Silent	SNP	T	TCGA-CV-7429-01A-11D-2129-08		31197067	71334325	38	47926											
WDR90	197335	broad.mit.edu	37	chr16	715685	715685	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acggcttcccccaggtgaacGaggtggtcttcagccccggg	6	7	14	14	3	2	1	1	1	1	0	3	2	3	1	4	5	2	1	4	5	1	2	rs150784706	by1000genomes	TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr16:715685G>A	uc002cii.1	+	35	4372	c.4318G>A	c.(4318-4320)GAG>AAG	p.E1440K	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Missense_Mutation_p.E55K|WDR90_uc010uul.1_Missense_Mutation_p.E39K|WDR90_uc002cio.1_Missense_Mutation_p.E39K|WDR90_uc010bqx.1_Missense_Mutation_p.E39K|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1440	WD 17.									ovary(1)	1		Hepatocellular(780;0.0218)				CCAGGTGAACGAGGTGGTCTT	0.647													5	66					0	0	0	0	A	715685	A	A	715685	3	1	262	1	0	0	0	0	1	0	0	0	17405	1059	37	1	4456	1	WDR90	16	715685	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08		715685	89639068	39	47927											
PTX4	390667	broad.mit.edu	37	chr16	1536086	1536086	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccgggaaccagcgcccgatCccagatagccaagccagaca	12	2	10	17	3	0	2	0	0	0	2	1	4	1	3	6	1	4	0	6	1	3	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr16:1536086C>T	uc010uvf.1	-	3	1276	c.1276G>A	c.(1276-1278)GAT>AAT	p.D426N		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	431	Pentaxin.					extracellular region	metal ion binding				0						AGCGCCCGATCCCAGATAGCC	0.642													12	62					0	0	0	0	T	1536086	T	T	1536086	3	4	262	1	0	0	0	0	1	0	0	0	12888	855	30	2	148	2	PTX4	16	1536086	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08	820401	1536086	88818667	40	47928											
TRAP1	10131	broad.mit.edu	37	chr16	3726128	3726128	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctaactcccgaagcttcggcGatttcaaacactccagaact	12	9	6	14	3	1	1	1	0	0	1	4	3	3	1	2	1	4	1	2	1	4	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr16:3726128G>A	uc002cvt.3	-	7	812	c.723C>T	c.(721-723)ATC>ATT	p.I241I	TRAP1_uc002cvs.2_Silent_p.I32I|TRAP1_uc010uxf.1_Silent_p.I188I	NM_016292	NP_057376	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1 precursor	241					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(1)	1		Ovarian(90;0.0261)				AAGCTTCGGCGATTTCAAACA	0.557													18	54					0	0	0	0	A	3726128	A	A	3726128	2	1	262	1	0	0	0	0	0	0	0	1	16522	1048	37	1		1	TRAP1	16	3726128	Silent	SNP	G	TCGA-CV-7429-01A-11D-2129-08	2190042	3726128	86628625	41	47929											
CREBBP	1387	broad.mit.edu	37	chr16	3779591	3779591	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagagggcgatgagctgcttGcacaccgggcagcccccgtt	7	6	14	14	3	0	2	0	1	0	1	0	3	0	2	3	2	4	5	3	2	0	2			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr16:3779591G>T	uc002cvv.2	-	31	5661	c.5457C>A	c.(5455-5457)TGC>TGA	p.C1819*	CREBBP_uc002cvw.2_Nonsense_Mutation_p.C1781*	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1819	TAZ-type 2.|Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGAGCTGCTTGCACACCGGGC	0.607			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				31	97					1.39806e-14	1.68172e-14	1	0	T	3779591	T	T	3779591	4	4	262	1	0	0	0	0	0	1	0	0	3876	1311	46	4	1875	4	CREBBP	16	3779591	Nonsense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	53463	3779591	86575162	42	47930											
KIAA0430	9665	broad.mit.edu	37	chr16	15716857	15716857	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttccgggataatctgtagtcTatgttgctgacttggacatc	8	15	10	8	1	2	1	0	1	2	0	4	3	3	3	1	2	1	3	1	2	3	6			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr16:15716857T>C	uc002ddr.2	-	11	2587	c.2394A>G	c.(2392-2394)ATA>ATG	p.I798M	KIAA0430_uc002ddq.2_Missense_Mutation_p.I632M|KIAA0430_uc010uzv.1_Missense_Mutation_p.I794M|KIAA0430_uc010uzw.1_Missense_Mutation_p.I797M	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	797	RRM.					peroxisome	nucleotide binding|RNA binding				0						ATCTGTAGTCTATGTTGCTGA	0.498													4	96					0	0	0	0	C	15716857	C	C	15716857	3	2	262	1	0	0	0	0	1	0	0	0	8216	1512	53	5	2902	5	KIAA0430	16	15716857	Missense_Mutation	SNP	T	TCGA-CV-7429-01A-11D-2129-08	11937266	15716857	74637896	43	47931											
HS3ST2	9956	broad.mit.edu	37	chr16	22926408	22926408	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcggaaccctgtgacccGtgccatctctgattacacgc	7	10	10	14	3	1	2	0	2	1	0	2	3	1	3	3	1	4	0	3	1	2	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr16:22926408G>A	uc002dli.2	+	2	701	c.629G>A	c.(628-630)CGT>CAT	p.R210H	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	210	PAPS and substrate (By similarity).|Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		CCTGTGACCCGTGCCATCTCT	0.587													38	120					0	0	0	0	A	22926408	A	A	22926408	3	1	262	1	0	0	0	0	1	0	0	0	7403	1145	40	1	635	1	HS3ST2	16	22926408	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	7209551	22926408	67428345	44	47932											
SF3B3	23450	broad.mit.edu	37	chr16	70602265	70602265	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtccaagaaagtttcatctGggttcgctacaagcgtaatg	11	12	10	8	2	2	1	1	0	1	1	4	1	3	1	1	1	2	4	1	1	5	4			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr16:70602265G>C	uc002ezf.2	+	22	3243	c.3032G>C	c.(3031-3033)TGG>TCG	p.W1011S		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	1011					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				AGTTTCATCTGGGTTCGCTAC	0.438													13	67					0	0	0	0	C	70602265	C	C	70602265	3	2	262	1	0	0	0	0	1	0	0	0	14217	1357	47	4	3114	4	SF3B3	16	70602265	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	47675857	70602265	19752488	45	47933											
MYO1C	4641	broad.mit.edu	37	chr17	1375218	1375218	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacctttgcaggaaagcttcGtatttgcggcgataggcaaa	11	10	11	9	3	0	0	0	0	0	0	1	2	0	1	1	3	3	4	1	3	4	5	rs78672478	byFrequency	TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr17:1375218G>A	uc002fsp.2	-	19	2224	c.2004C>T	c.(2002-2004)TAC>TAT	p.Y668Y	MYO1C_uc002fsn.2_Silent_p.Y649Y|MYO1C_uc002fso.2_Silent_p.Y633Y|MYO1C_uc010vqj.1_Silent_p.Y633Y|MYO1C_uc010vqk.1_Silent_p.Y644Y	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	668	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGAAAGCTTCGTATTTGCGGC	0.632													6	121					0	0	0	0	A	1375218	A	A	1375218	2	1	262	1	0	0	0	0	0	0	0	1	10123	1140	40	1		1	MYO1C	17	1375218	Silent	SNP	G	TCGA-CV-7429-01A-11D-2129-08		1375218	79819992	46	47934											
TNFSF13	8741	broad.mit.edu	37	chr17	7462496	7462496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgtggcttgtgccatggCtctgctgacccaacaaacag	8	8	12	13	1	1	1	0	1	1	0	1	1	1	1	3	3	4	3	3	3	2	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr17:7462496C>T	uc002ghk.2	+	1	888	c.140C>T	c.(139-141)GCT>GTT	p.A47V	SENP3_uc002ghm.2_5'Flank|TNFSF12-TNFSF13_uc002ghi.1_Intron|TNFSF13_uc002ghj.2_Missense_Mutation_p.A47V|TNFSF13_uc002ghl.2_Missense_Mutation_p.A47V|TNFSF13_uc010cmk.2_Missense_Mutation_p.A47V|TNFSF13_uc010vua.1_Missense_Mutation_p.A47V	NM_003808	NP_003799	O75888	TNF13_HUMAN	tumor necrosis factor ligand superfamily, member	47					mRNA metabolic process|positive regulation of cell proliferation|positive regulation of isotype switching to IgA isotypes|signal transduction	extracellular space|nucleoplasm	cytokine activity|tumor necrosis factor receptor binding			skin(1)	1		Prostate(122;0.157)				TGTGCCATGGCTCTGCTGACC	0.652													5	28					0	0	0	0	T	7462496	T	T	7462496	3	4	262	1	0	0	0	0	1	0	0	0	16371	797	28	4	142	4	TNFSF13	17	7462496	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08	6087278	7462496	73732714	47	47935											
MYH4	4622	broad.mit.edu	37	chr17	10369674	10369674	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtcatcatggccatgtcctcGatcttgtcatatttgggagg	7	14	11	9	1	4	0	3	0	1	0	6	2	5	1	2	3	0	0	2	3	1	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr17:10369674G>C	uc002gmn.2	-	4	375	c.264C>G	c.(262-264)ATC>ATG	p.I88M	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	88	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CCATGTCCTCGATCTTGTCAT	0.438													30	103					0	0	0	0	C	10369674	C	C	10369674	3	2	262	1	0	0	0	0	1	0	0	0	10090	1048	37	3	5703	3	MYH4	17	10369674	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	2907178	10369674	70825536	48	47936											
NUFIP2	57532	broad.mit.edu	37	chr17	27614070	27614071	+	Frame_Shift_Ins	INS	-	T	T																															ctttgggccgatcatcaaacINStttttgctgctcacaccagg																										TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr17:27614070_27614071insT	uc002hdy.3	-	2	1030_1031	c.941_942insA	c.(940-942)AAGfs	p.K314fs	NUFIP2_uc002hdx.3_Intron	NM_020772	NP_065823	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein	314						nucleus|polysomal ribosome	protein binding|RNA binding			skin(2)|ovary(1)|breast(1)	4			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			GATCATCAAACTTTTTGCTGCT	0.475													---	---	---								T	27614071	T	T	27614070	7	5	262	1	0	1	1	0	0	0	0	0	10803	564	20	0	1157	0	NUFIP2	17	27614070	Frame_Shift_Ins	INS	-	TCGA-CV-7429-01A-11D-2129-08	17244396	27614070	53581140	49	47937											
CSH2	1443	broad.mit.edu	37	chr17	61950577	61950577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatggccagctggtgcgcgcGatgggcttggagcatagcgt	7	8	17	9	4	0	0	0	0	0	0	0	2	0	1	1	4	4	3	1	4	2	2			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr17:61950577G>A	uc002jch.2	-	2	248	c.133C>T	c.(133-135)CGC>TGC	p.R45C	CSH2_uc002jcg.2_Missense_Mutation_p.R45C|CSH2_uc002jci.2_Missense_Mutation_p.R45C|GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Missense_Mutation_p.R45C	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	45					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						TGGTGCGCGCGATGGGCTTGG	0.592													20	102					0	0	0	0	A	61950577	A	A	61950577	3	1	262	1	0	0	0	0	1	0	0	0	3958	1058	37	1	584	1	CSH2	17	61950577	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	34336507	61950577	19244633	50	47938											
KCNJ2	3759	broad.mit.edu	37	chr17	68172221	68172221	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tattccaggttccacaaaacTtacgaagtccccaacactcc	13	9	4	15	1	0	0	0	0	0	0	4	1	4	0	5	1	3	1	5	1	6	4			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr17:68172221T>G	uc010dfg.2	+	2	1442	c.1041T>G	c.(1039-1041)ACT>ACG	p.T347T	KCNJ2_uc002jir.2_Silent_p.T347T	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	347	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					TCCACAAAACTTACGAAGTCC	0.418													22	136					0	0	0	0	G	68172221	G	G	68172221	2	3	262	1	0	0	0	0	0	0	0	1	8090	1596	56	5		5	KCNJ2	17	68172221	Silent	SNP	T	TCGA-CV-7429-01A-11D-2129-08	6221644	68172221	13022989	51	47939											
POTEC	388468	broad.mit.edu	37	chr18	14543020	14543020	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggtctccagaagtgcccatGttgctcttgccgctcccctt	4	13	9	15	1	2	1	0	0	2	1	4	1	3	1	5	1	3	3	5	1	1	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr18:14543020G>T	uc010dln.2	-	1	580	c.126C>A	c.(124-126)AAC>AAA	p.N42K	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	42										skin(3)	3						AAGTGCCCATGTTGCTCTTGC	0.587													11	193					2.48551e-13	2.86524e-13	1	0	T	14543020	T	T	14543020	3	4	262	1	0	0	0	0	1	0	0	0	12317	1368	48	4	1546	4	POTEC	18	14543020	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08		14543020	63534228	52	47940											
ZNF236	7776	broad.mit.edu	37	chr18	74536254	74536254	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttggtagagttaacacaCgtgcacattacggaaacgtt	13	10	9	9	3	0	1	0	0	0	1	0	2	0	2	0	2	4	4	0	2	4	5			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr18:74536254C>T	uc002lmi.2	+	1	139	c.-59C>T	c.(-61--57)CACGT>CATGT		ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236						cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		agttaacacacgtgcacatta	0													16	30					0	0	0	0	T	74536254	T	T	74536254	1	4	262	1	0	0	0	0	0	0	0	0	17856	551	19	1		1	ZNF236	18	74536254	Translation_Start_Site	SNP	C	TCGA-CV-7429-01A-11D-2129-08	59993234	74536254	3540994	53	47941											
TJP3	27134	broad.mit.edu	37	chr19	3734415	3734415	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcggagccccgaggccaGccagaccgactctcccgtgt	7	5	12	17	4	2	1	1	0	1	1	3	4	2	2	6	2	3	0	6	2	0	0			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr19:3734415G>T	uc010xhv.1	+	7	1067	c.1067G>T	c.(1066-1068)AGC>ATC	p.S356I	TJP3_uc010xhs.1_Missense_Mutation_p.S323I|TJP3_uc010xht.1_Missense_Mutation_p.S287I|TJP3_uc010xhu.1_Missense_Mutation_p.S332I|TJP3_uc010xhw.1_Missense_Mutation_p.S342I	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	337						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGAGGCCAGCCAGACCGAC	0.657													5	29					3.59834e-05	3.829e-05	1	0	T	3734415	T	T	3734415	3	4	262	1	0	0	0	0	1	0	0	0	15997	971	34	4	1093	4	TJP3	19	3734415	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08		3734415	55394568	54	47942											
CREB3L3	84699	broad.mit.edu	37	chr19	4171778	4171778	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagagtctccaggaagccccGgggcagactggggcttccag	9	5	15	12	1	1	2	0	0	1	2	3	3	2	3	4	5	1	2	4	5	2	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr19:4171778G>A	uc002lzl.2	+	10	1314	c.1198G>A	c.(1198-1200)GGG>AGG	p.G400R	CREB3L3_uc002lzm.2_Missense_Mutation_p.G390R|CREB3L3_uc010xib.1_Missense_Mutation_p.G389R|CREB3L3_uc010xic.1_3'UTR	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	400	Lumenal (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGAAGCCCCGGGGCAGACTG	0.667													29	83					0	0	0	0	A	4171778	A	A	4171778	3	1	262	1	0	0	0	0	1	0	0	0	3873	1116	39	1	1236	1	CREB3L3	19	4171778	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	437363	4171778	54957205	55	47943											
U2AF1L4	199746	broad.mit.edu	37	chr19	36233655	36233655	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagtgatcaggggaacaccGatggttcctctctcggggat	8	9	13	11	2	2	1	1	1	1	0	5	4	3	3	3	5	1	1	3	5	1	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr19:36233655G>A	uc002obg.2	-	8	834	c.525C>T	c.(523-525)ATC>ATT	p.I175I	TMEM149_uc002obb.2_5'Flank|TMEM149_uc002obc.2_5'Flank|TMEM149_uc002obd.3_5'Flank|TMEM149_uc010xsy.1_5'Flank|TMEM149_uc010eej.2_Intron|U2AF1L4_uc002obh.1_3'UTR|U2AF1L4_uc002obe.2_Missense_Mutation_p.R171W|U2AF1L4_uc002obf.2_Silent_p.I151I|PSENEN_uc002obi.1_5'Flank|PSENEN_uc002obj.1_5'Flank|PSENEN_uc002obk.1_5'Flank			Q8WU68	U2AF4_HUMAN	Homo sapiens cDNA FLJ35525 fis, clone SPLEN2001650.	Error:Variant_position_missing_in_Q8WU68_after_alignment					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex	nucleotide binding|RNA binding|zinc ion binding				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGGGAACACCGATGGTTCCTC	0.597													32	133					0	0	0	0	A	36233655	A	A	36233655	2	1	262	1	0	0	0	0	0	0	0	1	16890	1057	37	1		1	U2AF1L4	19	36233655	Silent	SNP	G	TCGA-CV-7429-01A-11D-2129-08	32061877	36233655	22895328	56	47944											
ITPKC	80271	broad.mit.edu	37	chr19	41239201	41239201	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtgcagtcaccaagcccCgctacatgcagtggagggaa	11	5	14	11	1	1	0	1	0	0	0	1	2	1	2	3	3	4	3	3	3	3	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr19:41239201C>T	uc002oot.2	+	4	1639	c.1606C>T	c.(1606-1608)CGC>TGC	p.R536C		NM_025194	NP_079470	Q96DU7	IP3KC_HUMAN	inositol 1,4,5-trisphosphate 3-kinase C	536	Substrate binding.					cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CACCAAGCCCCGCTACATGCA	0.642													4	15					0	0	0	0	T	41239201	T	T	41239201	3	4	262	1	0	0	0	0	1	0	0	0	7958	652	23	1	1620	1	ITPKC	19	41239201	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08	5005546	41239201	17889782	57	47945											
C20orf165	128497	broad.mit.edu	37	chr20	44516182	44516182	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccccccgctcaccttggccGgaaggcagaggacctggatg	7	5	14	15	2	1	1	1	0	0	1	1	4	1	4	6	5	0	2	6	5	1	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr20:44516182G>A	uc002xqf.2	-	1	57	c.48C>T	c.(46-48)TCC>TCT	p.S16S		NM_080608	NP_542175	Q9BR10	CT165_HUMAN	chromosome 20 open reading frame 165	16						integral to membrane					0		Myeloproliferative disorder(115;0.0122)				CACCTTGGCCGGAAGGCAGAG	0.607													9	45					0	0	0	0	A	44516182	A	A	44516182	2	1	262	1	0	0	0	0	0	0	0	1	2104	1103	39	1		1	C20orf165	20	44516182	Silent	SNP	G	TCGA-CV-7429-01A-11D-2129-08		44516182	18509338	58	47946											
ZFP64	55734	broad.mit.edu	37	chr20	50803572	50803572	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgccgcagatatggatgtCgggagtcagctccaccagca	10	7	13	11	2	1	1	1	0	0	1	3	4	2	3	3	2	3	3	3	2	1	1			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr20:50803572C>A	uc002xwl.2	-	2	434	c.85G>T	c.(85-87)GAC>TAC	p.D29Y	ZFP64_uc002xwk.2_Missense_Mutation_p.D29Y|ZFP64_uc002xwm.2_Missense_Mutation_p.D27Y|ZFP64_uc002xwn.2_Missense_Mutation_p.D29Y	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						ATATGGATGTCGGGAGTCAGC	0.512													8	31					5.4927e-09	6.07859e-09	1	0	A	50803572	A	A	50803572	3	1	262	1	0	0	0	0	1	0	0	0	17719	884	31	3	3171	3	ZFP64	20	50803572	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08	6287390	50803572	12221948	59	47947											
COL6A1	1291	broad.mit.edu	37	chr21	47412128	47412128	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaaggagaggcgggcgaCgaggtgagtgagggctcctg	10	4	21	6	3	0	4	0	2	0	2	1	8	1	4	1	5	0	1	1	5	1	0	rs140478280		TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chr21:47412128C>T	uc002zhu.1	+	17	1335	c.1233C>T	c.(1231-1233)GAC>GAT	p.D411D		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	411	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	AGGCGGGCGACGAGGTGAGTG	0.627													7	32					0	0	0	0	T	47412128	T	T	47412128	2	4	262	1	0	0	0	0	0	0	0	1	3714	535	19	1		1	COL6A1	21	47412128	Silent	SNP	C	TCGA-CV-7429-01A-11D-2129-08		47412128	717767	60	47948											
SMC1A	8243	broad.mit.edu	37	chrX	53432540	53432540	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgatatgaggtggctcatagCgaatcacatcaatcactagc	13	10	9	9	1	4	2	4	2	0	0	4	3	4	2	0	2	2	1	0	2	5	3			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chrX:53432540C>T	uc004dsg.2	-	11	1865	c.1796G>A	c.(1795-1797)CGC>CAC	p.R599H	SMC1A_uc011moe.1_Missense_Mutation_p.R577H|SMC1A_uc011mof.1_Missense_Mutation_p.R365H	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	599	Flexible hinge.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						TGGCTCATAGCGAATCACATC	0.532													32	14					0	0	0	0	T	53432540	T	T	53432540	3	4	262	1	0	0	0	0	1	0	0	0	14845	768	27	1	1965	1	SMC1A	23	53432540	Missense_Mutation	SNP	C	TCGA-CV-7429-01A-11D-2129-08		53432540	101838020	61	47949											
WDR44	54521	broad.mit.edu	37	chrX	117578415	117578415	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgaaaaatcagaagggaacGagaaaagtgaagatgctgaa	20	5	12	4	1	1	6	1	3	0	3	1	8	1	7	0	1	2	1	0	1	8	0			TCGA-CV-7429-01A-11D-2129-08	TCGA-CV-7429-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	14b42e59-e519-4efc-8105-6f6b83d33353	61924a75-3973-4d33-8d14-8ead1c8c9b54	g.chrX:117578415G>A	uc004eqn.2	+	19	3030	c.2605G>A	c.(2605-2607)GAG>AAG	p.E869K	WDR44_uc004eqo.2_Missense_Mutation_p.E861K|WDR44_uc011mtr.1_Missense_Mutation_p.E780K|WDR44_uc010nqi.2_Missense_Mutation_p.E579K	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	869						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						AGAAGGGAACGAGAAAAGTGA	0.393													42	41					0	0	0	0	A	117578415	A	A	117578415	3	1	262	1	0	0	0	0	1	0	0	0	17364	1059	37	1	2679	1	WDR44	23	117578415	Missense_Mutation	SNP	G	TCGA-CV-7429-01A-11D-2129-08	64145875	117578415	37692145	62	47950											
CROCC	9696	broad.mit.edu	37	chr1	17256382	17256382	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagcctggggagctggagacGcaggagcccagggggctggt	7	4	21	9	1	0	1	0	0	0	1	0	5	0	3	2	7	3	3	2	7	0	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr1:17256382G>T	uc001azt.2	+	4	462	c.393G>T	c.(391-393)ACG>ACT	p.T131T	CROCC_uc009voy.1_Intron|CROCC_uc009voz.1_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	131	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		AGCTGGAGACGCAGGAGCCCA	0.697													7	5					0.00307968	0.00327966	1	0	T	17256382	T	T	17256382	2	4	263	1	0	0	0	0	0	0	0	1	3908	1074	38	3		3	CROCC	1	17256382	Silent	SNP	G	TCGA-CV-7430-01A-11D-2129-08		17256382	231994239	1	47951											
PAFAH2	5051	broad.mit.edu	37	chr1	26301058	26301058	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgtctggaatttctcagtaTtgataaagaacacaggtcct	12	14	8	7	0	2	2	1	1	2	1	4	3	3	3	1	2	1	1	1	2	5	5			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr1:26301058T>G	uc001bld.3	-	9	1022	c.842A>C	c.(841-843)AAT>ACT	p.N281T	PAFAH2_uc001ble.3_Missense_Mutation_p.N281T	NM_000437	NP_000428	Q99487	PAFA2_HUMAN	platelet-activating factor acetylhydrolase 2	281					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			ovary(2)	2		Colorectal(325;3.47e-05)|Lung NSC(340;6.23e-05)|all_lung(284;9.48e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-25)|Colorectal(126;3.57e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00717)|READ - Rectum adenocarcinoma(331;0.0649)		TTTCTCAGTATTGATAAAGAA	0.468													19	15					0	0	0	0	G	26301058	G	G	26301058	3	3	263	1	0	0	0	0	1	0	0	0	11441	1493	52	5	348	5	PAFAH2	1	26301058	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08	9044676	26301058	222949563	2	47952											
ARID1A	8289	broad.mit.edu	37	chr1	27089635	27089635	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gatgagtcacgcctccatggGcaaccggccttatggcccta	8	8	11	14	2	1	1	1	1	0	0	2	2	2	1	5	3	1	1	5	3	3	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr1:27089635G>T	uc001bmv.1	+	8	2964	c.2591G>T	c.(2590-2592)GGC>GTC	p.G864V	ARID1A_uc001bmt.1_Missense_Mutation_p.G864V|ARID1A_uc001bmu.1_Missense_Mutation_p.G864V|ARID1A_uc001bmw.1_Missense_Mutation_p.G481V	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	864					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCCTCCATGGGCAACCGGCCT	0.587			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								24	23					3.28513e-13	3.71559e-13	1	0	T	27089635	T	T	27089635	3	4	263	1	0	0	0	0	1	0	0	0	913	1203	42	4	2621	4	ARID1A	1	27089635	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	788577	27089635	222160986	3	47953											
CLCA2	9635	broad.mit.edu	37	chr1	86913313	86913313	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actgtggaagcctttgtggaAagagacagcctccattttcc	10	11	10	10	0	0	1	0	0	0	1	2	4	2	3	4	2	2	0	4	2	2	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr1:86913313A>G	uc001dlr.3	+	11	1998	c.1836A>G	c.(1834-1836)GAA>GAG	p.E612E		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	612	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		CCTTTGTGGAAAGAGACAGCC	0.493													55	108					0	0	0	0	G	86913313	G	G	86913313	2	3	263	1	0	0	0	0	0	0	0	1	3473	11	1	5		5	CLCA2	1	86913313	Silent	SNP	A	TCGA-CV-7430-01A-11D-2129-08	59823678	86913313	162337308	4	47954											
AGL	178	broad.mit.edu	37	chr1	100358058	100358058	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcaactgtgtggagtaggaAaattcccttccctgccaatt	10	13	8	10	0	1	0	1	0	0	0	3	2	3	2	3	2	2	1	3	2	5	5			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr1:100358058A>G	uc001dsi.1	+	24	3554	c.3154A>G	c.(3154-3156)AAA>GAA	p.K1052E	AGL_uc001dsj.1_Missense_Mutation_p.K1052E|AGL_uc001dsk.1_Missense_Mutation_p.K1052E|AGL_uc001dsl.1_Missense_Mutation_p.K1052E|AGL_uc001dsm.1_Missense_Mutation_p.K1036E|AGL_uc001dsn.1_Missense_Mutation_p.K1035E	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1052	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TGGAGTAGGAAAATTCCCTTC	0.378													29	47					0	0	0	0	G	100358058	G	G	100358058	3	3	263	1	0	0	0	0	1	0	0	0	384	15	1	5	3313	5	AGL	1	100358058	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	13444745	100358058	148892563	5	47955											
LINGO4	339398	broad.mit.edu	37	chr1	151774779	151774779	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcggaggtccagcagggtCagagcagagaggcctgagaa	12	3	18	8	1	1	3	1	1	0	3	2	6	2	4	2	5	2	2	2	5	1	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr1:151774779C>T	uc001ezf.1	-	2	592	c.402G>A	c.(400-402)CTG>CTA	p.L134L		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	134	Extracellular (Potential).|LRR 4.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CCAGCAGGGTCAGAGCAGAGA	0.597													92	76					0	0	0	0	T	151774779	T	T	151774779	2	4	263	1	0	0	0	0	0	0	0	1	8859	813	29	2		2	LINGO4	1	151774779	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	51416721	151774779	97475842	6	47956											
CD1A	909	broad.mit.edu	37	chr1	158226702	158226702	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgcggggtgagcaggagcAgcagggcactcagcgagggg	9	3	21	8	2	1	1	1	1	0	0	1	4	1	2	0	6	5	4	0	6	0	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr1:158226702A>T	uc001frt.2	+	4	1264	c.731A>T	c.(730-732)CAG>CTG	p.Q244L		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	244	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GAGCAGGAGCAGCAGGGCACT	0.642													39	80					0	0	0	0	T	158226702	T	T	158226702	3	4	263	1	0	0	0	0	1	0	0	0	2989	188	7	5	745	5	CD1A	1	158226702	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	6451923	158226702	91023919	7	47957											
KCNJ9	3765	broad.mit.edu	37	chr1	160054148	160054148	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcaacggcttcgtggccGccttcctcttctccatcgag	5	11	8	17	4	3	0	1	0	2	0	7	1	4	0	5	2	1	1	5	2	1	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr1:160054148G>C	uc001fuy.1	+	2	570	c.328G>C	c.(328-330)GCC>CCC	p.A110P		NM_004983	NP_004974	Q92806	IRK9_HUMAN	potassium inwardly-rectifying channel subfamily	110					synaptic transmission	integral to membrane|plasma membrane	G-protein activated inward rectifier potassium channel activity|protein binding			ovary(1)|skin(1)	2	all_cancers(52;5.86e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTTCGTGGCCGCCTTCCTCTT	0.677													24	39					0	0	0	0	C	160054148	C	C	160054148	3	2	263	1	0	0	0	0	1	0	0	0	8096	1087	38	3	330	3	KCNJ9	1	160054148	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	1827446	160054148	89196473	8	47958											
RYR2	6262	broad.mit.edu	37	chr1	237949308	237949308	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaaaaggaagaaaaagaaGaaaccaaatctgaacctgaa	25	3	8	5	0	1	6	0	2	1	4	1	7	1	7	2	1	2	0	2	1	11	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr1:237949308G>C	uc001hyl.1	+	91	13420	c.13300G>C	c.(13300-13302)GAA>CAA	p.E4434Q	RYR2_uc010pya.1_Missense_Mutation_p.E849Q	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4434	Potential.|Glu-rich (acidic).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			agaaaaagaagaaACCAAATC	0.318													3	3					0	0	0	0	C	237949308	C	C	237949308	3	2	263	1	0	0	0	0	1	0	0	0	13834	943	33	2	13662	2	RYR2	1	237949308	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	77895160	237949308	11301313	9	47959											
OR2T12	127064	broad.mit.edu	37	chr1	248458473	248458473	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtcatcctcaggcacagctgCcagctcatgagagtgggata	10	8	12	11	0	3	1	3	1	0	1	4	3	4	2	2	2	3	3	2	2	1	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr1:248458473C>T	uc010pzj.1	-	1	408	c.408G>A	c.(406-408)TGG>TGA	p.W136*		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GGCACAGCTGCCAGCTCATGA	0.607													29	44					0	0	0	0	T	248458473	T	T	248458473	4	4	263	1	0	0	0	0	0	1	0	0	11073	740	26	4	557	4	OR2T12	1	248458473	Nonsense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	10509165	248458473	792148	10	47960											
MYT1L	23040	broad.mit.edu	37	chr2	1843127	1843127	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atgtggccctggccgtcgcaCccggggaccggacacctgta	6	6	14	15	4	0	0	0	0	0	0	1	2	0	2	5	5	0	2	5	5	1	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr2:1843127C>A	uc002qxe.2	-	21	3701	c.2874G>T	c.(2872-2874)GGG>GGT	p.G958G	MYT1L_uc002qxd.2_Silent_p.G956G|MYT1L_uc010ewk.2_5'UTR	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	958	C2HC-type 5.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGCCGTCGCACCCGGGGACCG	0.617													33	59					2.75727e-19	3.20704e-19	1	0	A	1843127	A	A	1843127	2	1	263	1	0	0	0	0	0	0	0	1	10160	494	18	4		4	MYT1L	2	1843127	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08		1843127	241356246	11	47961											
AGBL5	60509	broad.mit.edu	37	chr2	27276859	27276859	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctgctaccccttctcctaCagtgactgccaggaactgct	7	12	7	15	0	2	1	0	1	2	0	3	2	2	2	4	1	6	2	4	1	3	4			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr2:27276859C>A	uc002rie.2	+	4	700	c.483C>A	c.(481-483)TAC>TAA	p.Y161*	AGBL5_uc002ric.2_Nonsense_Mutation_p.Y161*|AGBL5_uc002rid.2_Nonsense_Mutation_p.Y161*|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	161					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTTCTCCTACAGTGACTGCC	0.552													75	129					4.2702e-19	4.93178e-19	1	0	A	27276859	A	A	27276859	4	1	263	1	0	0	0	0	0	1	0	0	378	489	17	4	493	4	AGBL5	2	27276859	Nonsense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	25433732	27276859	215922514	12	47962											
LTBP1	4052	broad.mit.edu	37	chr2	33614263	33614282	+	Frame_Shift_Del	DEL	AGCTGTGTAACATCCCCGTG	-	-																															ctccttagatgactatgctcAgctgtgtaacatccccgtga																								rs146752637		TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr2:33614263_33614282delAGCTGTGTAACATCCCCGTG	uc002ros.2	+	32	4727_4746	c.4727_4746delAGCTGTGTAACATCCCCGTG	c.(4726-4746)CAGCTGTGTAACATCCCCGTGfs	p.Q1576fs	LTBP1_uc002rot.2_Frame_Shift_Del_p.Q1250fs|LTBP1_uc002rou.2_Frame_Shift_Del_p.Q1249fs|LTBP1_uc002rov.2_Frame_Shift_Del_p.Q1196fs|LTBP1_uc010ymz.1_Frame_Shift_Del_p.Q1207fs|LTBP1_uc010yna.1_Frame_Shift_Del_p.Q1154fs|LTBP1_uc010ynb.1_Frame_Shift_Del_p.Q473fs	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1575_1581					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GACTATGCTCAGCTGTGTAACATCCCCGTGACGGGACGCC	0.564													---	---	---								-	33614282	-	-	33614263	7	5	263	1	0	1	0	1	0	0	0	0	9123	188	7	0	4905	0	LTBP1	2	33614263	Frame_Shift_Del	DEL	AGCTGTGTAACATCCCCGTG	TCGA-CV-7430-01A-11D-2129-08	6337404	33614263	209585110	13	47963											
APLF	200558	broad.mit.edu	37	chr2	68772422	68772422	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgatgaccggcctgaatgtCcctatggaccatcctgttat	8	12	9	12	1	0	3	0	3	0	0	2	4	2	4	5	2	0	1	5	2	3	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr2:68772422C>G	uc002sep.2	+	8	1437	c.1264C>G	c.(1264-1266)CCC>GCC	p.P422A	APLF_uc002seq.1_RNA|APLF_uc010fdf.2_Missense_Mutation_p.P398A|APLF_uc002ser.1_Missense_Mutation_p.P153A	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	422	PBZ-type 2.				double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						GCCTGAATGTCCCTATGGACC	0.423													29	67					0	0	0	0	G	68772422	G	G	68772422	3	3	263	1	0	0	0	0	1	0	0	0	776	855	30	2	1294	2	APLF	2	68772422	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	35158159	68772422	174426951	14	47964											
FER1L5	90342	broad.mit.edu	37	chr2	97361486	97361486	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgggattgcagctcatgcCgacggaggaggcctatgcac	8	7	14	12	3	1	0	1	0	0	0	2	4	1	3	2	4	4	3	2	4	1	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr2:97361486C>T	uc010fia.2	+	35	3983	c.3983C>T	c.(3982-3984)CCG>CTG	p.P1328L	FER1L5_uc002sws.3_Missense_Mutation_p.P46L|FER1L5_uc010fib.1_RNA|FER1L5_uc002swt.3_Missense_Mutation_p.P46L|FER1L5_uc010yus.1_Missense_Mutation_p.P45L	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1328						integral to membrane				ovary(1)	1						CAGCTCATGCCGACGGAGGAG	0.642													10	18					0	0	0	0	T	97361486	T	T	97361486	3	4	263	1	0	0	0	0	1	0	0	0	5846	652	23	1	4121	1	FER1L5	2	97361486	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	28589064	97361486	145837887	15	47965											
SAP130	79595	broad.mit.edu	37	chr2	128775458	128775458	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcatgtgctccctggcactGacttcagaatctcgaccaga	9	10	8	14	1	3	3	2	1	1	2	5	4	4	3	2	1	1	2	2	1	1	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr2:128775458G>A	uc002tpp.2	-	3	354	c.222C>T	c.(220-222)GTC>GTT	p.V74V	SAP130_uc002tpo.2_5'Flank|SAP130_uc010fmd.2_Silent_p.V74V|SAP130_uc002tpq.1_Silent_p.V48V	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	74					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CCCTGGCACTGACTTCAGAAT	0.498													29	62					0	0	0	0	A	128775458	A	A	128775458	2	1	263	1	0	0	0	0	0	0	0	1	13896	1277	45	2		2	SAP130	2	128775458	Silent	SNP	G	TCGA-CV-7430-01A-11D-2129-08	31413972	128775458	114423915	16	47966											
KCNJ3	3760	broad.mit.edu	37	chr2	155555887	155555887	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcatgttcagcgagcacgcGgtgatctccatgagggacgg	8	8	14	11	4	3	2	2	2	1	0	4	4	3	3	1	3	2	2	1	3	0	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr2:155555887G>T	uc002tyv.1	+	1	795	c.600G>T	c.(598-600)GCG>GCT	p.A200A	KCNJ3_uc010zce.1_Silent_p.A200A	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	200	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	GCGAGCACGCGGTGATCTCCA	0.597													4	33					0.00909568	0.00944109	1	0	T	155555887	T	T	155555887	2	4	263	1	0	0	0	0	0	0	0	1	8091	1103	39	3		3	KCNJ3	2	155555887	Silent	SNP	G	TCGA-CV-7430-01A-11D-2129-08	26780429	155555887	87643486	17	47967											
TTN	7273	broad.mit.edu	37	chr2	179484368	179484368	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccagttcaagcttagctCtggcttctttgtctttggca	5	16	9	11	0	4	0	1	0	3	0	4	0	4	0	1	2	3	5	1	2	2	5			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr2:179484368C>G	uc010zfg.1	-	199	39196	c.38972G>C	c.(38971-38973)AGA>ACA	p.R12991T	TTN_uc010zfh.1_Missense_Mutation_p.R6686T|TTN_uc010zfi.1_Missense_Mutation_p.R6619T|TTN_uc010zfj.1_Missense_Mutation_p.R6494T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13918							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGCTTAGCTCTGGCTTCTTT	0.373													35	57					0	0	0	0	G	179484368	G	G	179484368	3	3	263	1	0	0	0	0	1	0	0	0	16803	913	32	2	61469	2	TTN	2	179484368	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	23928481	179484368	63715005	18	47968											
SLC39A10	57181	broad.mit.edu	37	chr2	196592977	196592977	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggcttacataggcatgctCataggcacagctgttggtca	10	11	11	9	0	2	0	2	0	0	0	2	0	2	0	0	4	3	6	0	4	3	4			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr2:196592977C>T	uc002utg.3	+	9	2455	c.2241C>T	c.(2239-2241)CTC>CTT	p.L747L	SLC39A10_uc002uth.3_Silent_p.L747L|SLC39A10_uc010zgp.1_Silent_p.L297L	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	747	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TAGGCATGCTCATAGGCACAG	0.443													8	192					0	0	0	0	T	196592977	T	T	196592977	2	4	263	1	0	0	0	0	0	0	0	1	14677	813	29	2		2	SLC39A10	2	196592977	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	17108609	196592977	46606396	19	47969											
ARPC2	10109	broad.mit.edu	37	chr2	219110167	219110167	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaagaaggacgcagagccAgccacacagccccacaggtc	14	2	10	15	1	1	2	1	0	0	2	2	3	1	3	4	2	3	1	4	2	2	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr2:219110167A>T	uc002vhd.2	+	8	686	c.574A>T	c.(574-576)AGC>TGC	p.S192C	ARPC2_uc002vhe.2_Missense_Mutation_p.S192C|ARPC2_uc002vhf.2_Missense_Mutation_p.S78C	NM_152862	NP_690601	O15144	ARPC2_HUMAN	actin related protein 2/3 complex subunit 2	192					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		ACGCAGAGCCAGCCACACAGC	0.512													6	152					0	0	0	0	T	219110167	T	T	219110167	3	4	263	1	0	0	0	0	1	0	0	0	973	188	7	5	600	5	ARPC2	2	219110167	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	22517190	219110167	24089206	20	47970											
CLDND1	56650	broad.mit.edu	37	chr3	98240121	98240121	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actaatgaattcatcccagaTgcttttattcaaatcactgg	13	14	5	9	0	3	2	3	1	0	1	4	2	4	2	1	1	1	1	1	1	4	5			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr3:98240121T>A	uc003dsp.2	-	2	1028	c.148A>T	c.(148-150)ATC>TTC	p.I50F	CLDND1_uc003dso.2_Missense_Mutation_p.I50F|CLDND1_uc003dsq.2_Missense_Mutation_p.I50F|CLDND1_uc003dss.2_Missense_Mutation_p.I50F|CLDND1_uc003dsr.2_Intron|CLDND1_uc003dst.2_Missense_Mutation_p.I73F|CLDND1_uc003dsu.2_Missense_Mutation_p.I50F|CLDND1_uc003dsv.2_Missense_Mutation_p.I50F	NM_019895	NP_063948	Q9NY35	CLDN1_HUMAN	claudin domain containing 1 protein isoform a	50						integral to membrane				ovary(1)	1						TCATCCCAGATGCTTTTATTC	0.413													39	67					0	0	0	0	A	98240121	A	A	98240121	3	1	263	1	0	0	0	0	1	0	0	0	3508	1464	51	5	629	5	CLDND1	3	98240121	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08		98240121	99782309	21	47971											
MORC1	27136	broad.mit.edu	37	chr3	108773582	108773582	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgaatactcactgatgccGgtgtccttacagtactggac	10	12	9	10	1	1	2	1	2	0	0	2	3	2	3	2	2	4	1	2	2	4	4			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr3:108773582G>T	uc003dxl.2	-	14	1410	c.1323C>A	c.(1321-1323)ACC>ACA	p.T441T	MORC1_uc011bhn.1_Silent_p.T441T	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	441					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CACTGATGCCGGTGTCCTTAC	0.373													62	99					2.03652e-46	2.474e-46	1	0	T	108773582	T	T	108773582	2	4	263	1	0	0	0	0	0	0	0	1	9754	1103	39	3		3	MORC1	3	108773582	Silent	SNP	G	TCGA-CV-7430-01A-11D-2129-08	10533461	108773582	89248848	22	47972											
ALDH1L1	10840	broad.mit.edu	37	chr3	125856801	125856801	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccttcacttcctccaccAgcctggaggaaggagatgga	9	8	11	13	0	1	1	1	0	0	1	4	5	4	4	5	4	1	1	5	4	1	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr3:125856801A>T	uc003eim.1	-	10	1269	c.1079T>A	c.(1078-1080)CTG>CAG	p.L360Q	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.L259Q|ALDH1L1_uc003eio.2_Missense_Mutation_p.L62Q|ALDH1L1_uc010hsf.1_Missense_Mutation_p.L386Q	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	360	Acyl carrier.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TTCCTCCACCAGCCTGGAGGA	0.567													45	42					0	0	0	0	T	125856801	T	T	125856801	3	4	263	1	0	0	0	0	1	0	0	0	494	188	7	5	1685	5	ALDH1L1	3	125856801	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	17083219	125856801	72165629	23	47973											
SI	6476	broad.mit.edu	37	chr3	164739124	164739124	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttattggggtggttggaatGtttaacggtactggtacttc	7	16	13	5	1	0	0	0	0	0	0	1	1	0	1	0	6	3	4	0	6	5	8			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr3:164739124G>T	uc003fei.2	-	27	3209	c.3147C>A	c.(3145-3147)AAC>AAA	p.N1049K		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1049	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGGTTGGAATGTTTAACGGTA	0.368										HNSCC(35;0.089)			360	225					1.92225e-182	2.3526e-182	1	0	T	164739124	T	T	164739124	3	4	263	1	0	0	0	0	1	0	0	0	14362	1368	48	4	2424	4	SI	3	164739124	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	38882323	164739124	33283306	24	47974											
SERPINI1	5274	broad.mit.edu	37	chr3	167525052	167525052	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttcacagtggaacaggaaaTtgatttaaaagatgttttga	15	13	10	3	0	1	3	1	2	0	1	1	5	1	5	0	2	1	2	0	2	4	6			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr3:167525052T>A	uc003ffa.3	+	6	1100	c.902T>A	c.(901-903)ATT>AAT	p.I301N	SERPINI1_uc003ffb.3_Missense_Mutation_p.I301N	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	301					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						GAACAGGAAATTGATTTAAAA	0.338													67	235					0	0	0	0	A	167525052	A	A	167525052	3	1	263	1	0	0	0	0	1	0	0	0	14183	1493	52	5	920	5	SERPINI1	3	167525052	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08	2785928	167525052	30497378	25	47975											
LRRIQ4	344657	broad.mit.edu	37	chr3	169540249	169540249	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgaaaccagtttgaagttttCccccaggagctctgtgttct	8	13	9	11	1	2	1	0	1	2	0	3	3	3	2	3	1	2	4	3	1	2	4			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr3:169540249C>T	uc003fgb.2	+	1	540	c.540C>T	c.(538-540)TTC>TTT	p.F180F		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	180	LRR 7.										0						TTGAAGTTTTCCCCCAGGAGC	0.517													29	262					0	0	0	0	T	169540249	T	T	169540249	2	4	263	1	0	0	0	0	0	0	0	1	9081	854	30	2		2	LRRIQ4	3	169540249	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	2015197	169540249	28482181	26	47976											
SKIL	6498	broad.mit.edu	37	chr3	170102443	170102443	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catatcaagacagtcagagaAggctcacagtagtggtaaac	16	7	10	8	0	3	2	3	0	0	2	3	3	3	2	0	2	1	3	0	2	6	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr3:170102443A>G	uc003fgu.2	+	4	2031	c.1319A>G	c.(1318-1320)AAG>AGG	p.K440R	SKIL_uc011bps.1_Missense_Mutation_p.K420R|SKIL_uc003fgv.2_Intron|SKIL_uc003fgw.2_Missense_Mutation_p.K440R	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	440					cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			CAGTCAGAGAAGGCTCACAGT	0.398													77	401					0	0	0	0	G	170102443	G	G	170102443	3	3	263	1	0	0	0	0	1	0	0	0	14423	72	3	5	1329	5	SKIL	3	170102443	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	562194	170102443	27919987	27	47977											
PEX5L	51555	broad.mit.edu	37	chr3	179592166	179592166	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccgactcagagttgagggcGctttttccaccactcagttc	7	11	10	13	2	2	2	2	1	0	1	4	3	3	2	3	1	0	3	3	1	0	4	rs139208096		TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr3:179592166G>C	uc003fki.1	-	7	805	c.675C>G	c.(673-675)AGC>AGG	p.S225R	PEX5L_uc011bqd.1_Missense_Mutation_p.S182R|PEX5L_uc011bqe.1_Missense_Mutation_p.S33R|PEX5L_uc011bqf.1_Missense_Mutation_p.S117R|PEX5L_uc003fkj.1_Missense_Mutation_p.S190R|PEX5L_uc010hxd.1_Missense_Mutation_p.S223R|PEX5L_uc011bqg.1_Missense_Mutation_p.S201R|PEX5L_uc011bqh.1_Missense_Mutation_p.S166R	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	225					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			AGTTGAGGGCGCTTTTTCCAC	0.393													75	202					0	0	0	0	C	179592166	C	C	179592166	3	2	263	1	0	0	0	0	1	0	0	0	11804	1078	38	3	1241	3	PEX5L	3	179592166	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	9489723	179592166	18430264	28	47978											
CCDC39	339829	broad.mit.edu	37	chr3	180397180	180397180	+	Translation_Start_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gctactcatgactgcaaacgGatagagaagatacagagcaa	17	6	10	8	1	1	4	1	1	0	3	1	6	1	5	0	1	5	3	0	1	6	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr3:180397180G>C	uc010hxe.2	-	1	104	c.-11C>G	c.(-13--9)ATCCG>ATGCG		CCDC39_uc003fkn.2_Intron	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39						axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ACTGCAAACGGATAGAGAAGA	0.582													55	432					0	0	0	0	C	180397180	C	C	180397180	1	2	263	1	0	0	0	0	0	0	0	0	2824	1189	41	2		2	CCDC39	3	180397180	Translation_Start_Site	SNP	G	TCGA-CV-7430-01A-11D-2129-08	805014	180397180	17625250	29	47979											
IQCG	84223	broad.mit.edu	37	chr3	197619560	197619560	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgtggctttgagagcatttAgttcattctgtttcatttct	6	21	8	6	0	4	1	2	1	2	1	4	2	4	1	0	1	1	4	0	1	1	8			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr3:197619560A>G	uc003fyo.2	-	9	1180	c.1034T>C	c.(1033-1035)CTA>CCA	p.L345P	IQCG_uc003fyn.2_Missense_Mutation_p.L247P|IQCG_uc003fyp.2_Missense_Mutation_p.L345P|IQCG_uc003fym.2_Missense_Mutation_p.L46P	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	345											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		GAGAGCATTTAGTTCATTCTG	0.438													87	604					0	0	0	0	G	197619560	G	G	197619560	3	3	263	1	0	0	0	0	1	0	0	0	7849	420	15	5	309	5	IQCG	3	197619560	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	17222380	197619560	402870	30	47980											
UGT2B7	7364	broad.mit.edu	37	chr4	69962284	69962290	+	Frame_Shift_Del	DEL	TTTTGCT	-	-																															ttttgctaatacaactgagcTtttgctttagctctgggaat																										TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr4:69962284_69962290delTTTTGCT	uc003heg.3	+	1	92_98	c.46_52delTTTTGCT	c.(46-54)TTTTGCTTTfs	p.F16fs	UGT2B7_uc010ihq.2_Frame_Shift_Del_p.F16fs	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	16_18					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						ACAACTGAGCTTTTGCTTTAGCTCTGG	0.42													---	---	---								-	69962290	-	-	69962284	7	5	263	1	0	1	0	1	0	0	0	0	17030	1609	56	0	48	0	UGT2B7	4	69962284	Frame_Shift_Del	DEL	TTTTGCT	TCGA-CV-7430-01A-11D-2129-08		69962284	121191992	31	47981											
ANK2	287	broad.mit.edu	37	chr4	114277023	114277023	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttgcactccctagccgaGatagcgaagtcctcagcgct	10	8	9	14	3	1	1	1	0	0	1	3	3	3	1	3	0	5	2	3	0	4	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr4:114277023G>A	uc003ibe.3	+	38	7349	c.7249G>A	c.(7249-7251)GAT>AAT	p.D2417N	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Intron|ANK2_uc011cgb.1_Missense_Mutation_p.D2432N	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2384					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCCTAGCCGAGATAGCGAAGT	0.498													18	24					0	0	0	0	A	114277023	A	A	114277023	3	1	263	1	0	0	0	0	1	0	0	0	621	942	33	2	7464	2	ANK2	4	114277023	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	44314739	114277023	76877253	32	47982											
TIGD4	201798	broad.mit.edu	37	chr4	153691671	153691671	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	taaggaagtacattttggtaCcagacagtcgaagggtctac	13	10	11	7	1	1	1	0	0	1	1	2	3	1	2	1	3	3	2	1	3	6	6			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr4:153691671C>T	uc003imy.2	-	2	1268	c.486G>A	c.(484-486)TGG>TGA	p.W162*		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	162					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					CATTTTGGTACCAGACAGTCG	0.363													24	21					0	0	0	0	T	153691671	T	T	153691671	4	4	263	1	0	0	0	0	0	1	0	0	15964	508	18	4	1056	4	TIGD4	4	153691671	Nonsense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	39414648	153691671	37462605	33	47983											
TKTL2	84076	broad.mit.edu	37	chr4	164393621	164393621	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccatcttctccagtggatacCccacagtgggaaccaataag	12	8	8	13	0	2	0	0	0	2	0	3	2	2	2	5	2	2	0	5	2	4	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr4:164393621C>G	uc003iqp.3	-	1	1427	c.1266G>C	c.(1264-1266)GGG>GGC	p.G422G		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	422						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CAGTGGATACCCCACAGTGGG	0.478													26	21					0	0	0	0	G	164393621	G	G	164393621	2	3	263	1	0	0	0	0	0	0	0	1	16002	610	22	4		4	TKTL2	4	164393621	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	10701950	164393621	26760655	34	47984											
SEMA5A	9037	broad.mit.edu	37	chr5	9202097	9202097	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaagatgccatagatcaaaTccagctcaggcaggaagaaa	18	6	9	8	0	2	3	2	0	0	3	3	4	3	4	2	2	2	2	2	2	6	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr5:9202097T>C	uc003jek.2	-	9	1614	c.902A>G	c.(901-903)GAT>GGT	p.D301G		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	301	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						ATAGATCAAATCCAGCTCAGG	0.438													28	49					0	0	0	0	C	9202097	C	C	9202097	3	2	263	1	0	0	0	0	1	0	0	0	14102	1435	50	5	2382	5	SEMA5A	5	9202097	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08		9202097	171713163	35	47985											
DNAH5	1767	broad.mit.edu	37	chr5	13876803	13876803	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttgacatacctttttggtgGagttgataattgtgctaagc	9	16	10	6	0	0	2	0	2	0	0	0	3	0	3	1	2	3	2	1	2	3	8			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr5:13876803G>T	uc003jfd.2	-	22	3428	c.3386C>A	c.(3385-3387)TCC>TAC	p.S1129Y		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1129	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTTTTGGTGGAGTTGATAAT	0.383									Kartagener_syndrome				20	67					2.52088e-20	2.99582e-20	1	0	T	13876803	T	T	13876803	3	4	263	1	0	0	0	0	1	0	0	0	4626	1174	41	2	10720	2	DNAH5	5	13876803	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	4674706	13876803	167038457	36	47986											
PDZD2	23037	broad.mit.edu	37	chr5	32088330	32088330	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgcacaaggaagatccttcGgagtcagaagaggaacagat	15	7	12	7	1	1	4	1	0	0	4	3	7	2	7	1	3	2	1	1	3	4	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr5:32088330G>T	uc003jhl.2	+	20	5164	c.4776G>T	c.(4774-4776)TCG>TCT	p.S1592S	PDZD2_uc003jhm.2_Silent_p.S1592S	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1592					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AAGATCCTTCGGAGTCAGAAG	0.577													60	97					2.6711e-34	3.22103e-34	1	0	T	32088330	T	T	32088330	2	4	263	1	0	0	0	0	0	0	0	1	11755	1103	39	3		3	PDZD2	5	32088330	Silent	SNP	G	TCGA-CV-7430-01A-11D-2129-08	18211527	32088330	148826930	37	47987											
MAP3K1	4214	broad.mit.edu	37	chr5	56167806	56167806	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgatgaagaaagtcttacAgtgtgtgaagacggctgcag	12	10	13	6	1	1	5	0	3	1	2	1	5	1	5	0	1	2	2	0	1	4	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr5:56167806A>T	uc003jqw.3	+	7	1872	c.1371A>T	c.(1369-1371)ACA>ACT	p.T457T		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	457	RING-type.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		AAAGTCTTACAGTGTGTGAAG	0.428													27	30					0	0	0	0	T	56167806	T	T	56167806	2	4	263	1	0	0	0	0	0	0	0	1	9296	175	7	5		5	MAP3K1	5	56167806	Silent	SNP	A	TCGA-CV-7430-01A-11D-2129-08	24079476	56167806	124747454	38	47988											
PCDHB2	56133	broad.mit.edu	37	chr5	140475050	140475051	+	Missense_Mutation	DNP	GG	TA	TA																															gcgggagtccacccaggtccGgcacggccctggtacggatt																										TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr5:140475050_140475051GG>TA	uc003lil.2	+	1	814_815	c.676_677GG>TA	c.(676-678)GGC>TAC	p.G226Y	PCDHB2_uc003lim.1_5'UTR	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	226	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCCAGGTCCGGCACGGCCCTG	0.579													17	34					0	0	0	0	TA	140475051	TA	TA	140475050	3	4	263	1	0	0	0	0	1	0	0	0	11596	1116	39	3	678	3	PCDHB2	5	140475050	Missense_Mutation	DNP	GG	TCGA-CV-7430-01A-11D-2129-08	84307244	140475050	40440210	39	47989											
PCDHGA4	56111	broad.mit.edu	37	chr5	140735600	140735600	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagccaatggagacgtgaCgtattctttccggaaagtaa	13	9	12	7	3	1	2	0	1	1	1	2	5	2	4	2	3	1	2	2	3	4	4			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr5:140735600C>A	uc003ljq.1	+	1	833	c.833C>A	c.(832-834)ACG>AAG	p.T278K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.T278K	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	278	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGACGTGACGTATTCTTTC	0.458													11	25					1.58986e-06	1.74992e-06	1	0	A	140735600	A	A	140735600	3	1	263	1	0	0	0	0	1	0	0	0	11610	536	19	3	835	3	PCDHGA4	5	140735600	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	260550	140735600	40179660	40	47990											
FAF2	23197	broad.mit.edu	37	chr5	175913467	175913467	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accacaggatctacagctatGttgtctcaagacctcaacca	13	9	6	13	0	3	1	2	0	2	1	4	2	3	2	3	1	3	2	3	1	4	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr5:175913467G>A	uc003mej.3	+	3	297	c.244G>A	c.(244-246)GTT>ATT	p.V82I		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	82					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						CTACAGCTATGTTGTCTCAAG	0.443													42	65					0	0	0	0	A	175913467	A	A	175913467	3	1	263	1	0	0	0	0	1	0	0	0	5398	1377	48	4	254	4	FAF2	5	175913467	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	35177867	175913467	5001793	41	47991											
RREB1	6239	broad.mit.edu	37	chr6	7231221	7231221	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagaagcctgaggaggaggcGgggagcagcgagcagccctc	11	2	18	10	2	0	2	0	1	0	1	1	6	0	5	2	5	5	2	2	5	2	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr6:7231221G>A	uc003mxc.2	+	10	3279	c.2889G>A	c.(2887-2889)GCG>GCA	p.A963A	RREB1_uc003mxb.2_Silent_p.A963A|RREB1_uc010jnx.2_Silent_p.A963A	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	963					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				AGGAGGAGGCGGGGAGCAGCG	0.632													17	12					0	0	0	0	A	7231221	A	A	7231221	2	1	263	1	0	0	0	0	0	0	0	1	13744	1103	39	1		1	RREB1	6	7231221	Silent	SNP	G	TCGA-CV-7430-01A-11D-2129-08		7231221	163883846	42	47992											
SASH1	23328	broad.mit.edu	37	chr6	148840966	148840966	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagaagaagaaaaggcccaGaaagtgtcccgctccctcac	14	4	9	14	1	1	4	1	0	0	4	3	4	3	4	4	1	0	1	4	1	5	0	rs138202713	byFrequency	TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr6:148840966G>A	uc003qme.1	+	10	1621	c.1146G>A	c.(1144-1146)CAG>CAA	p.Q382Q	SASH1_uc011eeb.1_Silent_p.Q143Q	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	382							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		AAAAGGCCCAGAAAGTGTCCC	0.547													4	21					0	0	0	0	A	148840966	A	A	148840966	2	1	263	1	0	0	0	0	0	0	0	1	13913	933	33	2		2	SASH1	6	148840966	Silent	SNP	G	TCGA-CV-7430-01A-11D-2129-08	141609745	148840966	22274101	43	47993											
MTHFD1L	25902	broad.mit.edu	37	chr6	151293189	151293189	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actggttggtgaagaaggatTtgtaggtaagttatttcttt	10	17	12	2	0	1	2	0	1	1	1	1	3	1	3	0	4	0	4	0	4	5	7			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr6:151293189T>A	uc003qob.2	+	20	2388	c.2120T>A	c.(2119-2121)TTT>TAT	p.F707Y	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Missense_Mutation_p.F708Y|MTHFD1L_uc003qoc.2_Missense_Mutation_p.F655Y	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	707	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		GAAGAAGGATTTGTAGGTAAG	0.398													28	56					0	0	0	0	A	151293189	A	A	151293189	3	1	263	1	0	0	0	0	1	0	0	0	9981	1841	64	5	2198	5	MTHFD1L	6	151293189	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08	2452223	151293189	19821878	44	47994											
TIAM2	26230	broad.mit.edu	37	chr6	155451295	155451295	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caacctggggagcctctcccCctcaggtatccgcctttctg	5	10	9	17	1	3	0	1	0	2	0	5	1	4	1	6	3	2	1	6	3	2	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr6:155451295C>T	uc003qqb.2	+	6	2211	c.938C>T	c.(937-939)CCC>CTC	p.P313L	TIAM2_uc003qqe.2_Missense_Mutation_p.P313L	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	313					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGCCTCTCCCCCTCAGGTATC	0.557													27	51					0	0	0	0	T	155451295	T	T	155451295	3	4	263	1	0	0	0	0	1	0	0	0	15957	623	22	4	940	4	TIAM2	6	155451295	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	4158106	155451295	15663772	45	47995											
ZNF804B	219578	broad.mit.edu	37	chr7	88962841	88962841	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatcatatccgataaacagcGgtccaccatgccaaatcgac	15	7	6	13	3	1	0	1	0	0	0	4	2	3	0	4	1	3	0	4	1	5	2	rs139327261	byFrequency	TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr7:88962841G>A	uc011khi.1	+	4	1083	c.545G>A	c.(544-546)CGG>CAG	p.R182Q		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	182						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GATAAACAGCGGTCCACCATG	0.418										HNSCC(36;0.09)			33	69					0	0	0	0	A	88962841	A	A	88962841	3	1	263	1	0	0	0	0	1	0	0	0	18238	1116	39	1	559	1	ZNF804B	7	88962841	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08		88962841	70175822	46	47996											
SLC7A2	6542	broad.mit.edu	37	chr8	17407860	17407860	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatggggctggtggctttaTgccttatggctttacgggaa	6	14	14	7	1	0	0	0	0	0	0	0	1	0	1	1	6	2	3	1	6	5	6			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr8:17407860T>C	uc011kyc.1	+	5	918	c.749T>C	c.(748-750)ATG>ACG	p.M250T	SLC7A2_uc011kyd.1_Missense_Mutation_p.M290T|SLC7A2_uc011kye.1_Missense_Mutation_p.M290T|SLC7A2_uc011kyf.1_Missense_Mutation_p.M250T	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	250	Helical; (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	GGTGGCTTTATGCCTTATGGC	0.448													35	18					0	0	0	0	C	17407860	C	C	17407860	3	2	263	1	0	0	0	0	1	0	0	0	14761	1464	51	5	887	5	SLC7A2	8	17407860	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08		17407860	128956162	47	47997											
KCNU1	157855	broad.mit.edu	37	chr8	36766941	36766941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctttgtaatgcccttgagagCcagcaactataccaggaagg	12	9	10	10	0	0	1	0	1	0	1	0	3	0	2	3	2	5	2	3	2	5	5			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr8:36766941C>G	uc010lvw.2	+	21	2306	c.2219C>G	c.(2218-2220)GCC>GGC	p.A740G	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	740	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CCCTTGAGAGCCAGCAACTAT	0.458													93	230					0	0	0	0	G	36766941	G	G	36766941	3	3	263	1	0	0	0	0	1	0	0	0	8132	739	26	4	2301	4	KCNU1	8	36766941	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	19359081	36766941	109597081	48	47998											
SLCO5A1	81796	broad.mit.edu	37	chr8	70667725	70667725	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttcactgttgtttgattTctccttcagaacatcgtcat	7	19	6	9	1	4	2	3	1	1	1	6	2	4	2	1	0	1	3	1	0	1	6			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr8:70667725T>C	uc003xyl.2	-	4	1899	c.1192A>G	c.(1192-1194)AAA>GAA	p.K398E	SLCO5A1_uc010lzb.2_Missense_Mutation_p.K398E|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Missense_Mutation_p.K398E|SLCO5A1_uc010lzc.2_Missense_Mutation_p.K398E	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	398	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TTGTTTGATTTCTCCTTCAGA	0.358													31	40					0	0	0	0	C	70667725	C	C	70667725	3	2	263	1	0	0	0	0	1	0	0	0	14795	1792	62	5	1382	5	SLCO5A1	8	70667725	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08	33900784	70667725	75696297	49	47999											
COL14A1	7373	broad.mit.edu	37	chr8	121228628	121228628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaacctgagaatctccaatGttggctctaacagtgctcga	12	10	9	10	1	2	1	0	1	2	1	4	4	2	1	2	1	3	3	2	1	4	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr8:121228628G>A	uc003yox.2	+	14	1901	c.1636G>A	c.(1636-1638)GTT>ATT	p.V546I	COL14A1_uc003yoy.2_Missense_Mutation_p.V224I|COL14A1_uc010mde.1_Missense_Mutation_p.V224I	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	546	Fibronectin type-III 4.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AATCTCCAATGTTGGCTCTAA	0.353													49	65					0	0	0	0	A	121228628	A	A	121228628	3	1	263	1	0	0	0	0	1	0	0	0	3686	1377	48	4	1686	4	COL14A1	8	121228628	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	50560903	121228628	25135394	50	48000											
FAM135B	51059	broad.mit.edu	37	chr8	139277978	139277978	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caagagtaaatgaactcggaAgaccacagcatcatttatgg	16	8	9	8	1	1	3	1	1	0	2	2	4	1	4	1	2	2	2	1	2	6	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr8:139277978A>G	uc003yuy.2	-	4	436	c.265T>C	c.(265-267)TTC>CTC	p.F89L	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	89										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGAACTCGGAAGACCACAGCA	0.488										HNSCC(54;0.14)			29	50					0	0	0	0	G	139277978	G	G	139277978	3	3	263	1	0	0	0	0	1	0	0	0	5477	72	3	5	4023	5	FAM135B	8	139277978	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	18049350	139277978	7086044	51	48001											
JRK	8629	broad.mit.edu	37	chr8	143745934	143745934	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acggcacgcagcgcccgcagCtgccccacttcctgcgcact	6	5	10	20	5	0	0	0	0	0	0	1	0	1	0	4	1	4	5	4	1	0	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr8:143745934C>A	uc003ywo.2	-	3	2056	c.1542G>T	c.(1540-1542)CAG>CAT	p.Q514H	JRK_uc003ywp.2_Missense_Mutation_p.Q514H|JRK_uc010mew.1_Missense_Mutation_p.S515I	NM_001077527	NP_001070995			jerky isoform b												0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				GCGCCCgcagctgccccactt	0.343													4	15					0.00909568	0.00944109	1	0	A	143745934	A	A	143745934	3	1	263	1	0	0	0	0	1	0	0	0	8003	797	28	4	262	4	JRK	8	143745934	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	4467956	143745934	2618088	52	48002											
GLIS3	169792	broad.mit.edu	37	chr9	4117821	4117821	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctcatgtggatcagcagttTatagcgggcgttgaagggct	8	12	14	7	2	2	1	2	1	1	0	3	2	2	2	0	3	2	4	0	3	3	4			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr9:4117821T>C	uc003zhw.1	-	3	1386	c.1192A>G	c.(1192-1194)AAA>GAA	p.K398E	GLIS3_uc003zhx.1_Missense_Mutation_p.K553E|GLIS3_uc003zic.1_Missense_Mutation_p.K553E|GLIS3_uc003zie.1_Missense_Mutation_p.K553E|GLIS3_uc010mhh.1_Missense_Mutation_p.K428E|GLIS3_uc003zid.1_Missense_Mutation_p.K331E|GLIS3_uc010mhi.1_Missense_Mutation_p.K360E|GLIS3_uc003zif.1_Missense_Mutation_p.K331E|GLIS3_uc003zig.1_Missense_Mutation_p.K397E|GLIS3_uc003zih.1_Missense_Mutation_p.K331E|GLIS3_uc003zhy.1_Missense_Mutation_p.K331E|GLIS3_uc003zhz.1_Missense_Mutation_p.K331E|GLIS3_uc003zib.1_Missense_Mutation_p.K397E|GLIS3_uc010mhg.1_Missense_Mutation_p.K331E	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	398	C2H2-type 2; atypical.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		ATCAGCAGTTTATAGCGGGCG	0.567													69	48					0	0	0	0	C	4117821	C	C	4117821	3	2	263	1	0	0	0	0	1	0	0	0	6484	1763	61	5	1167	5	GLIS3	9	4117821	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08		4117821	137095610	53	48003											
ZNF484	83744	broad.mit.edu	37	chr9	95610231	95610231	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctcacattcatggcattCatgctgcttttcttcagcac	7	15	6	13	0	5	0	4	0	1	0	5	0	5	0	1	1	4	4	1	1	0	5			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr9:95610231C>T	uc004asu.1	-	5	987	c.838G>A	c.(838-840)GAA>AAA	p.E280K	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Missense_Mutation_p.E282K|ZNF484_uc010mrb.1_Missense_Mutation_p.E244K|ZNF484_uc004asv.1_Missense_Mutation_p.E244K	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	280	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATGGCATTCATGCTGCTTT	0.428													34	102					0	0	0	0	T	95610231	T	T	95610231	3	4	263	1	0	0	0	0	1	0	0	0	18004	835	29	2	1724	2	ZNF484	9	95610231	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	91492410	95610231	45603200	54	48004											
KIAA0368	23392	broad.mit.edu	37	chr9	114173351	114173351	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgttgctctgacattctcatTttctttttagccaaatacct	8	19	4	10	0	3	1	1	1	3	0	4	1	3	1	2	0	3	2	2	0	3	8			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr9:114173351T>G	uc004bfe.1	-	23	2820	c.2820A>C	c.(2818-2820)AAA>AAC	p.K940N		NM_001080398	NP_001073867			KIAA0368 protein												0						ACATTCTCATTTTCTTTTTAG	0.418													188	190					0	0	0	0	G	114173351	G	G	114173351	3	3	263	1	0	0	0	0	1	0	0	0	8210	1838	64	5	3349	5	KIAA0368	9	114173351	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08	18563120	114173351	27040080	55	48005											
PAPPA	5069	broad.mit.edu	37	chr9	119065052	119065052	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcagatgaacccagccggtgCtatttccatgatggtgatgg	9	10	13	9	1	0	4	0	3	0	1	1	4	1	4	3	3	3	2	3	3	2	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr9:119065052C>A	uc004bjn.2	+	10	3351	c.2970C>A	c.(2968-2970)TGC>TGA	p.C990*	PAPPA_uc011lxp.1_Nonsense_Mutation_p.C685*|PAPPA_uc011lxq.1_Nonsense_Mutation_p.C365*	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	990					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CCAGCCGGTGCTATTTCCATG	0.458													17	74					0.00278032	0.00298021	1	0	A	119065052	A	A	119065052	4	1	263	1	0	0	0	0	0	1	0	0	11486	805	28	4	3008	4	PAPPA	9	119065052	Nonsense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	4891701	119065052	22148379	56	48006											
OLFML2A	169611	broad.mit.edu	37	chr9	127557384	127557384	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acgcctacgtccacaaggtgGcctcccagatgaacacactg	11	6	9	15	2	0	2	0	1	0	1	2	2	2	2	4	2	2	0	4	2	3	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr9:127557384G>A	uc004bov.2	+	3	549	c.436G>A	c.(436-438)GCC>ACC	p.A146T	OLFML2A_uc010mwr.1_Intron	NM_182487	NP_872293	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A precursor	146											0						CCACAAGGTGGCCTCCCAGAT	0.652													5	12					0	0	0	0	A	127557384	A	A	127557384	3	1	263	1	0	0	0	0	1	0	0	0	10911	1203	42	4	446	4	OLFML2A	9	127557384	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	8492332	127557384	13656047	57	48007											
OLFML2A	169611	broad.mit.edu	37	chr9	127566456	127566456	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actccgcagagcccaactccGcagagcaggatgaggctgag	11	4	13	13	2	0	4	0	2	0	2	2	5	2	5	3	2	3	4	3	2	1	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr9:127566456G>A	uc004bov.2	+	6	1116	c.1003G>A	c.(1003-1005)GCA>ACA	p.A335T	OLFML2A_uc010mwr.1_Missense_Mutation_p.A299T|OLFML2A_uc004bow.2_Missense_Mutation_p.A121T	NM_182487	NP_872293	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A precursor	335											0						GCCCAACTCCGCAGAGCAGGA	0.562													64	43					0	0	0	0	A	127566456	A	A	127566456	3	1	263	1	0	0	0	0	1	0	0	0	10911	1087	38	1	1025	1	OLFML2A	9	127566456	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	9072	127566456	13646975	58	48008											
SCAI	286205	broad.mit.edu	37	chr9	127715225	127715225	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatatgattctggataatttCgtgtttcctggtaggcaaag	10	15	11	5	1	1	1	0	1	1	0	3	3	2	2	1	3	0	3	1	3	4	6			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr9:127715225C>T	uc004bpe.2	-	18	1763	c.1682G>A	c.(1681-1683)CGA>CAA	p.R561Q	SCAI_uc004bpd.2_Missense_Mutation_p.R584Q|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	561					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						TGGATAATTTCGTGTTTCCTG	0.358													64	45					0	0	0	0	T	127715225	T	T	127715225	3	4	263	1	0	0	0	0	1	0	0	0	13934	884	31	1	142	1	SCAI	9	127715225	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	148769	127715225	13498206	59	48009											
MRPS2	51116	broad.mit.edu	37	chr9	138395504	138395504	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgcccacatggcctaccgcaAgggcatcatcttgtttataa	10	10	8	13	2	2	0	1	0	1	0	2	0	2	0	3	2	1	3	3	2	4	5			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr9:138395504A>T	uc004cfv.3	+	4	490	c.416A>T	c.(415-417)AAG>ATG	p.K139M	MRPS2_uc004cfw.3_Missense_Mutation_p.K49M|MRPS2_uc004cfx.3_Missense_Mutation_p.K54M|MRPS2_uc010nat.2_Missense_Mutation_p.K120M|uc004cfy.2_RNA	NM_016034	NP_057118	Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	139					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome				0				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)		GCCTACCGCAAGGGCATCATC	0.577													30	70					0	0	0	0	T	138395504	T	T	138395504	3	4	263	1	0	0	0	0	1	0	0	0	9884	72	3	5	430	5	MRPS2	9	138395504	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	10680279	138395504	2817927	60	48010											
NOXA1	10811	broad.mit.edu	37	chr9	140327703	140327704	+	Missense_Mutation	DNP	CG	TT	TT																															cccggcccctgtgaggacccCgcgggtgctggggtaagagg																										TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	268e0e78-73a5-43f9-a25f-cd862c4438bd	g.chr9:140327703_140327704CG>TT	uc004cmv.2	+	10	1032_1033	c.897_898CG>TT	c.(895-900)CCCGCG>CCTTCG	p.A300S	C9orf167_uc011mew.1_Intron|NOXA1_uc004cmu.2_Missense_Mutation_p.A300S|NOXA1_uc010nch.2_Missense_Mutation_p.A244S	NM_006647	NP_006638	Q86UR1	NOXA1_HUMAN	NADPH oxidase activator 1	300			Missing (in NOXA1truncated, a cDNA isolated from Caco-2 cells treated with butyrate).		regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|superoxide metabolic process	cytoplasm|NADPH oxidase complex	Rac GTPase binding|superoxide-generating NADPH oxidase activator activity				0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000238)|Epithelial(140;0.000982)		GTGAGGACCCCGCGGGTGCTGG	0.653													8	11					0	0	0	0	TT	140327704	TT	TT	140327703	3	4	263	1	0	0	0	0	1	0	0	0	10614	639	23	1	935	1	NOXA1	9	140327703	Missense_Mutation	DNP	CG	TCGA-CV-7430-01A-11D-2129-08	1932199	140327703	885728	61	48011	106	2									
NOXA1	10811	broad.mit.edu	37	chr9	140327704	140327704	+	Missense_Mutation	SNP	G	T	T																															ccggcccctgtgaggaccccGcgggtgctggggtaagaggc																										TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr9:140327704G>T	uc004cmv.2	+	10	1033	c.898G>T	c.(898-900)GCG>TCG	p.A300S	C9orf167_uc011mew.1_Intron|NOXA1_uc004cmu.2_Missense_Mutation_p.A300S|NOXA1_uc010nch.2_Missense_Mutation_p.A244S	NM_006647	NP_006638	Q86UR1	NOXA1_HUMAN	NADPH oxidase activator 1	300			Missing (in NOXA1truncated, a cDNA isolated from Caco-2 cells treated with butyrate).		regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|superoxide metabolic process	cytoplasm|NADPH oxidase complex	Rac GTPase binding|superoxide-generating NADPH oxidase activator activity				0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000238)|Epithelial(140;0.000982)		TGAGGACCCCGCGGGTGCTGG	0.652													8	11					0.00829132	0.00871651	1	0	T	140327704	T	T	140327704	3	4	263	1	0	0	0	0	1	0	0	0	10614	1087	38	3	936	3	NOXA1	9	140327704	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	1	140327704	885727	62	48012	106	2									
FAM178A	55719	broad.mit.edu	37	chr10	102684308	102684308	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttctgggcattctacagAatccaccaaacacaaggaac	15	8	7	11	0	2	1	0	0	2	1	3	2	3	2	2	2	3	2	2	2	5	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr10:102684308A>G	uc001krt.3	+	5	2092	c.1550A>G	c.(1549-1551)GAA>GGA	p.E517G	FAM178A_uc001krr.1_Missense_Mutation_p.E517G|FAM178A_uc001krs.2_Missense_Mutation_p.E517G|FAM178A_uc001kru.1_Missense_Mutation_p.E452G	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	517											0						CATTCTACAGAATCCACCAAA	0.393													58	88					0	0	0	0	G	102684308	G	G	102684308	3	3	263	1	0	0	0	0	1	0	0	0	5531	246	9	5	1568	5	FAM178A	10	102684308	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08		102684308	32850439	63	48013											
SORCS1	114815	broad.mit.edu	37	chr10	108371726	108371726	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctccactcagggatgtcCgggttgtagtcatccaggtt	6	12	11	12	1	2	0	2	0	0	0	6	1	6	1	4	3	0	3	4	3	1	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr10:108371726C>T	uc001kym.2	-	22	2984	c.2976G>A	c.(2974-2976)CCG>CCA	p.P992P	SORCS1_uc001kyl.2_Silent_p.P992P|SORCS1_uc009xxs.2_Silent_p.P992P|SORCS1_uc001kyn.1_Silent_p.P992P|SORCS1_uc001kyo.2_Silent_p.P992P	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	992	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CAGGGATGTCCGGGTTGTAGT	0.483													27	52					0	0	0	0	T	108371726	T	T	108371726	2	4	263	1	0	0	0	0	0	0	0	1	14994	639	23	1		1	SORCS1	10	108371726	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	5687418	108371726	27163021	64	48014											
FAM160B1	57700	broad.mit.edu	37	chr10	116590627	116590627	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagcttgcaccttctcttcCtttacaagaagattttgttt	8	18	6	9	0	1	2	0	0	1	2	3	2	2	2	2	0	3	4	2	0	4	9			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr10:116590627C>G	uc001lcb.2	+	2	397	c.62C>G	c.(61-63)CCT>CGT	p.P21R	FAM160B1_uc001lcc.2_Missense_Mutation_p.P21R	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	21										lung(1)	1						CCTTCTCTTCCTTTACAAGAA	0.318													27	52					0	0	0	0	G	116590627	G	G	116590627	3	3	263	1	0	0	0	0	1	0	0	0	5498	681	24	4	68	4	FAM160B1	10	116590627	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	8218901	116590627	18944120	65	48015											
ODF3	113746	broad.mit.edu	37	chr11	194639	194641	+	5'Flank	DEL	GGG	-	-																															gggacatcaggaacacactcGgggccacagccacacacaca																								rs112126401		TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr11:194639_194641delGGG	uc001lob.2	+						ODF3_uc010qvk.1_5'Flank|ODF3_uc001loc.2_5'Flank	NM_053280	NP_444510	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm				ovary(1)	1		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		GAACACACTCGGGGCCACAGCCA	0.552													---	---	---								-	194641	-	-	194639	6	5	263	0	1	1	0	1	0	0	0	0	10883	1131	39	0		0	ODF3	11	194639	5'Flank	DEL	GGG	TCGA-CV-7430-01A-11D-2129-08		194639	134811877	66	48016											
ZNF214	7761	broad.mit.edu	37	chr11	7021319	7021319	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aactgtgactaaaaccctttCcacaatcatgacatttatag	15	12	4	10	0	1	2	1	2	0	0	2	2	2	2	2	0	2	0	2	0	6	5			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr11:7021319C>T	uc001mfa.2	-	3	1898	c.1595G>A	c.(1594-1596)GGA>GAA	p.G532E	ZNF214_uc010ray.1_Missense_Mutation_p.G532E|ZNF214_uc009yfh.1_Missense_Mutation_p.G532E	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	532	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		AAAACCCTTTCCACAATCATG	0.413													34	36					0	0	0	0	T	7021319	T	T	7021319	3	4	263	1	0	0	0	0	1	0	0	0	17837	855	30	2	229	2	ZNF214	11	7021319	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	6826680	7021319	127985197	67	48017											
RRAS2	22800	broad.mit.edu	37	chr11	14316390	14316390	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatggctccaaactcttctTgtcctgctgtatccaaaact	9	14	5	13	0	3	0	1	0	2	0	6	0	6	0	3	1	3	3	3	1	4	3	rs113954997		TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr11:14316390T>A	uc001mlf.3	-	3	528	c.215A>T	c.(214-216)CAA>CTA	p.Q72L	RRAS2_uc009ygq.2_5'UTR|RRAS2_uc010rco.1_Missense_Mutation_p.Q78L	NM_012250	NP_036382	P62070	RRAS2_HUMAN	related RAS viral (r-ras) oncogene homolog 2	72	GTP (By similarity).		Q -> L (in an ovarian cancer sample; somatic mutation).			endoplasmic reticulum|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)	1				Epithelial(150;0.203)		AAACTCTTCTTGTCCTGCTGT	0.393													59	47					0	0	0	0	A	14316390	A	A	14316390	3	1	263	1	0	0	0	0	1	0	0	0	13742	1812	63	5	415	5	RRAS2	11	14316390	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08	7295071	14316390	120690126	68	48018											
IGHMBP2	3508	broad.mit.edu	37	chr11	68696742	68696742	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcccaggccctcgaggcgagCtgctggatccccctgctgaa	6	6	13	16	2	0	1	0	1	0	0	2	4	1	2	4	3	3	3	4	3	1	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr11:68696742C>T	uc001ook.1	+	8	1254	c.1152C>T	c.(1150-1152)AGC>AGT	p.S384S	IGHMBP2_uc001ooj.1_RNA|IGHMBP2_uc001ool.1_5'Flank	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	384	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TCGAGGCGAGCTGCTGGATCC	0.622													64	112					0	0	0	0	T	68696742	T	T	68696742	2	4	263	1	0	0	0	0	0	0	0	1	7630	796	28	4		4	IGHMBP2	11	68696742	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	54380352	68696742	66309774	69	48019											
DLG2	1740	broad.mit.edu	37	chr11	84996292	84996292	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttttgaagtctgtcatggCacggagcaagaagggatgtc	11	11	13	6	1	2	2	1	1	1	1	3	4	2	4	0	3	1	2	0	3	3	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr11:84996292C>T	uc001pak.2	-	4	470	c.158G>A	c.(157-159)TGC>TAC	p.C53Y		NM_001142699	NP_001136171	Q15700	DLG2_HUMAN	chapsyn-110 isoform 1	Error:Variant_position_missing_in_Q15700_after_alignment						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCTGTCATGGCACGGAGCAAG	0.383													50	111					0	0	0	0	T	84996292	T	T	84996292	3	4	263	1	0	0	0	0	1	0	0	0	4577	710	25	4	3074	4	DLG2	11	84996292	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	16299550	84996292	50010224	70	48020											
TMEM133	83935	broad.mit.edu	37	chr11	100863058	100863058	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcatgacctcacatcactgcGtaggacccggaaatcacatc	12	7	8	14	2	3	1	3	1	0	0	4	3	3	3	2	2	1	2	2	2	2	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr11:100863058G>T	uc001pgf.2	+	1	248	c.19G>T	c.(19-21)GTA>TTA	p.V7L		NM_032021	NP_114410	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	7						integral to membrane					0		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		ACATCACTGCGTAGGACCCGG	0.428													24	46					7.87624e-14	8.97017e-14	1	0	T	100863058	T	T	100863058	3	4	263	1	0	0	0	0	1	0	0	0	16115	1145	40	3	21	3	TMEM133	11	100863058	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	15866766	100863058	34143458	71	48021											
MCAM	4162	broad.mit.edu	37	chr11	119181165	119181165	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagttcgctcttacgagacGggggtagcgtgctgggagga	8	8	17	8	4	1	1	0	0	1	1	2	4	1	3	0	4	3	4	0	4	3	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr11:119181165G>A	uc001pwf.2	-	15	1834	c.1805C>T	c.(1804-1806)CCG>CTG	p.P602L	MCAM_uc001pwg.1_Intron	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	602	Cytoplasmic (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		CTTACGAGACGGGGGTAGCGT	0.587													64	111					0	0	0	0	A	119181165	A	A	119181165	3	1	263	1	0	0	0	0	1	0	0	0	9421	1116	39	1	143	1	MCAM	11	119181165	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	18318107	119181165	15825351	72	48022											
ROBO4	54538	broad.mit.edu	37	chr11	124756993	124756993	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggacaggcgactggaagctGggctggggccagagagggaa	10	4	20	7	1	0	1	0	0	0	1	0	6	0	4	1	7	1	2	1	7	2	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr11:124756993G>T	uc001qbg.2	-	15	2455	c.2315C>A	c.(2314-2316)CCA>CAA	p.P772Q	ROBO4_uc010sas.1_Missense_Mutation_p.P627Q|ROBO4_uc001qbh.2_Missense_Mutation_p.P662Q|ROBO4_uc001qbi.2_Missense_Mutation_p.P330Q	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	772	Pro/Ser-rich.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		ACTGGAAGCTGGGCTGGGGCC	0.652													14	37					1.49906e-05	1.61741e-05	1	0	T	124756993	T	T	124756993	3	4	263	1	0	0	0	0	1	0	0	0	13581	1348	47	4	724	4	ROBO4	11	124756993	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	5575828	124756993	10249523	73	48023											
RECQL	5965	broad.mit.edu	37	chr12	21630754	21630754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tacctcataatatagatttgGcctattaaaagaagctgtaa	16	13	6	6	0	1	2	1	0	0	2	1	2	1	2	2	1	2	2	2	1	9	8			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr12:21630754G>A	uc001rex.2	-	8	1198	c.850C>T	c.(850-852)CCA>TCA	p.P284S	RECQL_uc001rey.2_Missense_Mutation_p.P284S	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	284					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						TATAGATTTGGCCTATTAAAA	0.328								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					18	52					0	0	0	0	A	21630754	A	A	21630754	3	1	263	1	0	0	0	0	1	0	0	0	13266	1203	42	4	1135	4	RECQL	12	21630754	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08		21630754	112221141	74	48024											
KCNJ8	3764	broad.mit.edu	37	chr12	21918866	21918866	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggtttctcatccagctctcGggcactgcaccgtggagcag	7	9	12	13	2	2	0	1	0	2	0	5	1	3	1	2	3	3	5	2	3	0	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr12:21918866G>A	uc001rff.2	-	3	1404	c.1066C>T	c.(1066-1068)CGA>TGA	p.R356*		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	356	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	TCCAGCTCTCGGGCACTGCAC	0.463													61	155					0	0	0	0	A	21918866	A	A	21918866	4	1	263	1	0	0	0	0	0	1	0	0	8095	1124	39	1	212	1	KCNJ8	12	21918866	Nonsense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	288112	21918866	111933029	75	48025											
FAM113B	91523	broad.mit.edu	37	chr12	47629946	47629946	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcagcccatgcaggttTcttcgtcgaagacaatttta	10	13	7	11	2	3	1	2	0	1	1	5	2	3	1	1	1	2	2	1	1	3	4			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr12:47629946T>C	uc001rpn.2	+	4	1831	c.1100T>C	c.(1099-1101)TTC>TCC	p.F367S	FAM113B_uc001rpq.2_Missense_Mutation_p.F367S	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	367	Pro-rich.						hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					CATGCAGGTTTCTTCGTCGAA	0.522													88	182					0	0	0	0	C	47629946	C	C	47629946	3	2	263	1	0	0	0	0	1	0	0	0	5430	1783	62	5	1102	5	FAM113B	12	47629946	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08	25711080	47629946	86221949	76	48026											
MLL2	8085	broad.mit.edu	37	chr12	49420628	49420628	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggcccatcagtggcccCgtcaccctcctcatgacaga	8	6	10	17	1	3	2	3	1	0	1	4	2	4	2	5	3	0	1	5	3	0	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr12:49420628C>T	uc001rta.3	-	48	15121	c.15121G>A	c.(15121-15123)GGG>AGG	p.G5041R		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5041					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCAGTGGCCCCGTCACCCTCC	0.607			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			24	114					0	0	0	0	T	49420628	T	T	49420628	3	4	263	1	0	0	0	0	1	0	0	0	9674	652	23	1	1520	1	MLL2	12	49420628	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	1790682	49420628	84431267	77	48027											
LRRC10	376132	broad.mit.edu	37	chr12	70004207	70004207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	actcagctcacagaccacatCcggcagctgggtgaggcagt	10	6	12	13	1	2	2	2	1	0	1	3	2	3	2	2	3	2	4	2	3	0	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr12:70004207C>T	uc001svc.2	-	1	736	c.412G>A	c.(412-414)GAT>AAT	p.D138N		NM_201550	NP_963844	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	138	LRR 4.					nucleus					0	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			CAGACCACATCCGGCAGCTGG	0.632													22	107					0	0	0	0	T	70004207	T	T	70004207	3	4	263	1	0	0	0	0	1	0	0	0	9017	855	30	2	425	2	LRRC10	12	70004207	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	20583579	70004207	63847688	78	48028											
NAV3	89795	broad.mit.edu	37	chr12	78225481	78225481	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccaaggagaaagaagacagCaaggttagttgctgaagtta	16	7	13	5	0	0	4	0	1	0	3	0	5	0	4	1	2	2	5	1	2	7	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr12:78225481C>A	uc001syp.2	+	1	413	c.240C>A	c.(238-240)AGC>AGA	p.S80R	NAV3_uc001syo.2_Missense_Mutation_p.S80R	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	80	CH.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAGAAGACAGCAAGGTTAGTT	0.413										HNSCC(70;0.22)			38	13					8.16277e-20	9.6309e-20	1	0	A	78225481	A	A	78225481	3	1	263	1	0	0	0	0	1	0	0	0	10238	709	25	4	242	4	NAV3	12	78225481	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	8221274	78225481	55626414	79	48029											
WSCD2	9671	broad.mit.edu	37	chr12	108634152	108634152	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagcgggaccactggcgcagCggacggaccatctgcatcaa	10	4	14	13	4	2	0	1	0	1	0	2	4	2	3	2	4	3	2	2	4	1	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr12:108634152C>T	uc001tms.2	+	8	1920	c.1176C>T	c.(1174-1176)AGC>AGT	p.S392S	WSCD2_uc001tmt.2_Silent_p.S392S|WSCD2_uc001tmu.2_Silent_p.S140S	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	392						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						ACTGGCGCAGCGGACGGACCA	0.607													118	58					0	0	0	0	T	108634152	T	T	108634152	2	4	263	1	0	0	0	0	0	0	0	1	17475	767	27	1		1	WSCD2	12	108634152	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	30408671	108634152	25217743	80	48030											
SELPLG	6404	broad.mit.edu	37	chr12	109016914	109016914	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggctctggcgtcaggccCgggctcttggccttggacag	3	9	16	13	2	3	0	1	0	2	0	3	1	3	1	2	6	0	2	2	6	0	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr12:109016914C>A	uc001tni.2	-	2	1330	c.1170G>T	c.(1168-1170)CCG>CCT	p.P390P	SELPLG_uc001tnh.2_Silent_p.P380P|SELPLG_uc010sxe.1_Silent_p.P406P	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	390	Cytoplasmic (Potential).				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0						GCGTCAGGCCCGGGCTCTTGG	0.642													19	5					1.15919e-05	1.25898e-05	1	0	A	109016914	A	A	109016914	2	1	263	1	0	0	0	0	0	0	0	1	14085	639	23	3		3	SELPLG	12	109016914	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	382762	109016914	24834981	81	48031											
BRCA2	675	broad.mit.edu	37	chr13	32972595	32972595	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaacacccataaagaaaaaAgaactgaattctcctcagat	20	7	5	9	0	2	4	1	1	1	3	3	5	2	4	2	0	2	0	2	0	8	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr13:32972595A>T	uc001uub.1	+	27	10172	c.9945A>T	c.(9943-9945)AAA>AAT	p.K3315N		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3315					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TAAAGAAAAAAGAACTGAATT	0.368			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			33	54					0	0	0	0	T	32972595	T	T	32972595	3	4	263	1	0	0	0	0	1	0	0	0	1504	69	3	5	10047	5	BRCA2	13	32972595	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08		32972595	82197283	82	48032											
SUGT1	10910	broad.mit.edu	37	chr13	53233376	53233376	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacttttacagaaggacaaaAattagatagtaagtattaaa	21	11	6	3	0	0	2	0	0	0	2	0	3	0	3	0	1	2	2	0	1	11	7	rs12875900		TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr13:53233376A>G	uc001vhc.2	+	5	545	c.320A>G	c.(319-321)AAA>AGA	p.K107R	SUGT1_uc001vha.2_RNA|SUGT1_uc001vhb.2_Missense_Mutation_p.K107R|SUGT1_uc010thb.1_Missense_Mutation_p.K51R|SUGT1_uc001vhd.2_5'UTR	NM_001130912	NP_001124384	Q9Y2Z0	SUGT1_HUMAN	suppressor of G2 allele of SKP1 isoform a	107	TPR 3.				mitosis	kinetochore|ubiquitin ligase complex	binding				0		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.25e-08)		GAAGGACAAAAATTAGATAGT	0.249													12	12					0	0	0	0	G	53233376	G	G	53233376	3	3	263	1	0	0	0	0	1	0	0	0	15435	14	1	5	338	5	SUGT1	13	53233376	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	20260781	53233376	61936502	83	48033											
RASA3	22821	broad.mit.edu	37	chr13	114758033	114758033	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccgtctcacggtccccatCaatgtccagctggatgttgg	6	11	10	14	2	2	0	2	0	1	0	6	1	5	1	4	3	1	2	4	3	1	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr13:114758033C>G	uc001vui.2	-	22	2304	c.2173G>C	c.(2173-2175)GAT>CAT	p.D725H	RASA3_uc010tkk.1_Missense_Mutation_p.D693H|RASA3_uc001vuj.2_Missense_Mutation_p.D342H	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	725					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			CGGTCCCCATCAATGTCCAGC	0.483													16	31					0	0	0	0	G	114758033	G	G	114758033	3	3	263	1	0	0	0	0	1	0	0	0	13127	826	29	2	343	2	RASA3	13	114758033	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	61524657	114758033	411845	84	48034											
KTN1	3895	broad.mit.edu	37	chr14	56142559	56142559	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctttatttttacagttgaagGcacagttaaatgaaacactc	14	14	6	7	0	0	2	0	2	0	0	1	2	0	2	0	1	2	3	0	1	6	7			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr14:56142559G>C	uc001xcb.2	+	42	4080	c.3778G>C	c.(3778-3780)GCA>CCA	p.A1260P	KTN1_uc001xce.2_Missense_Mutation_p.A1203P|KTN1_uc001xcc.2_Missense_Mutation_p.A1260P|KTN1_uc001xcd.2_Missense_Mutation_p.A1209P|KTN1_uc010trb.1_Missense_Mutation_p.A1232P|KTN1_uc001xcf.1_Missense_Mutation_p.A1209P|KTN1_uc010aoq.2_Missense_Mutation_p.A498P|KTN1_uc010trc.1_Missense_Mutation_p.A237P|KTN1_uc001xcg.2_Missense_Mutation_p.A193P	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	1260	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						ACAGTTGAAGGCACAGTTAAA	0.368			T	RET	papillary thryoid								15	46					0	0	0	0	C	56142559	C	C	56142559	3	2	263	1	0	0	0	0	1	0	0	0	8625	1203	42	4	3936	4	KTN1	14	56142559	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08		56142559	51206981	85	48035											
SLC8A3	6547	broad.mit.edu	37	chr14	70633852	70633852	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctctgttttgtagtccacatAcatggtctttgacatgtctc	7	17	7	10	0	3	1	0	1	3	0	5	1	4	1	1	1	1	2	1	1	2	5			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr14:70633852A>T	uc001xly.2	-	2	2042	c.1288T>A	c.(1288-1290)TAT>AAT	p.Y430N	SLC8A3_uc001xlw.2_Missense_Mutation_p.Y430N|SLC8A3_uc001xlx.2_Missense_Mutation_p.Y430N|SLC8A3_uc001xlz.2_Missense_Mutation_p.Y430N|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	430	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TAGTCCACATACATGGTCTTT	0.522													73	112					0	0	0	0	T	70633852	T	T	70633852	3	4	263	1	0	0	0	0	1	0	0	0	14772	391	14	5	1634	5	SLC8A3	14	70633852	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	14491293	70633852	36715688	86	48036											
C14orf102	55051	broad.mit.edu	37	chr14	90767686	90767686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcagagtggccagcctgcCgcagaaagtggcactgctga	9	7	13	12	1	1	3	1	1	1	2	2	3	1	3	3	2	3	3	3	2	1	0	rs150270537		TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr14:90767686C>T	uc001xyi.1	-	7	1473	c.1442G>A	c.(1441-1443)CGG>CAG	p.R481Q	C14orf102_uc010atp.1_5'UTR|C14orf102_uc001xyj.1_Missense_Mutation_p.R250Q	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	481							protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		GCCAGCCTGCCGCAGAAAGTG	0.517													20	32					0	0	0	0	T	90767686	T	T	90767686	3	4	263	1	0	0	0	0	1	0	0	0	1741	652	23	1	2084	1	C14orf102	14	90767686	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	20133834	90767686	16581854	87	48037											
MKRN3	7681	broad.mit.edu	37	chr15	23811475	23811475	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaggggtttctttgaagcCgagagagacaatgcagaccg	13	7	14	7	2	1	4	0	1	1	3	1	7	1	4	2	2	2	2	2	2	3	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr15:23811475C>T	uc001ywh.3	+	1	1022	c.546C>T	c.(544-546)GCC>GCT	p.A182A	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Silent_p.A182A	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	182						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TCTTTGAAGCCGAGAGAGACA	0.617													22	32					0	0	0	0	T	23811475	T	T	23811475	2	4	263	1	0	0	0	0	0	0	0	1	9661	639	23	1		1	MKRN3	15	23811475	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08		23811475	78719917	88	48038											
CHST14	113189	broad.mit.edu	37	chr15	40763950	40763950	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacagcgtggacgtccgcCtcaagatggaccaccgcagt	9	6	13	13	4	1	1	1	0	0	1	2	4	2	4	4	3	1	1	4	3	1	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr15:40763950C>A	uc001zlw.2	+	1	738	c.538C>A	c.(538-540)CTC>ATC	p.L180I		NM_130468	NP_569735	Q8NCH0	CHSTE_HUMAN	dermatan 4 sulfotransferase 1	180	Lumenal (Potential).				carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding				0		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		GGACGTCCGCCTCAAGATGGA	0.602													39	51					2.35958e-20	2.82461e-20	1	0	A	40763950	A	A	40763950	3	1	263	1	0	0	0	0	1	0	0	0	3417	681	24	4	540	4	CHST14	15	40763950	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	16952475	40763950	61767442	89	48039											
LIPC	3990	broad.mit.edu	37	chr15	58834054	58834054	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctcagccggcccagccagTgaacgtggggctggtggact	6	7	16	12	2	1	1	1	1	1	0	2	2	1	2	3	5	3	1	3	5	1	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr15:58834054T>C	uc010bga.1	+	5	952	c.344T>C	c.(343-345)GTG>GCG	p.V115A	LIPC_uc010bfz.1_Missense_Mutation_p.V115A|LIPC_uc002afa.1_Missense_Mutation_p.V115A|LIPC_uc010bgb.1_Missense_Mutation_p.V13A|LIPC_uc010ugy.1_Intron	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	115					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		GCCCAGCCAGTGAACGTGGGG	0.652													15	24					0	0	0	0	C	58834054	C	C	58834054	3	2	263	1	0	0	0	0	1	0	0	0	8862	1696	59	5	354	5	LIPC	15	58834054	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08	18070104	58834054	43697338	90	48040											
CLEC16A	23274	broad.mit.edu	37	chr16	11097000	11097000	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtcccttgagatgaacaagCacaagggcaagaggcgggtg	12	5	16	8	1	0	3	0	2	0	2	1	4	1	3	1	4	2	2	1	4	4	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr16:11097000C>T	uc002dao.2	+	11	1371	c.1141C>T	c.(1141-1143)CAC>TAC	p.H381Y	CLEC16A_uc002dan.3_Missense_Mutation_p.H379Y	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	381										ovary(1)|central_nervous_system(1)	2						GATGAACAAGCACAAGGGCAA	0.537													13	34					0	0	0	0	T	11097000	T	T	11097000	3	4	263	1	0	0	0	0	1	0	0	0	3515	710	25	4	1179	4	CLEC16A	16	11097000	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08		11097000	79257753	91	48041											
CDH8	1006	broad.mit.edu	37	chr16	61859022	61859022	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccatatctttggcttggatAacaaccaggtactcctcctt	9	13	6	13	0	1	0	0	0	1	0	3	1	3	1	4	3	3	2	4	3	4	6			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr16:61859022A>T	uc002eog.1	-	5	981	c.729T>A	c.(727-729)GTT>GTA	p.V243V	CDH8_uc002eoh.2_Silent_p.V12V	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	243	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TGGCTTGGATAACAACCAGGT	0.458													16	72					0	0	0	0	T	61859022	T	T	61859022	2	4	263	1	0	0	0	0	0	0	0	1	3131	349	13	5		5	CDH8	16	61859022	Silent	SNP	A	TCGA-CV-7430-01A-11D-2129-08	50762022	61859022	28495731	92	48042											
CDH3	1001	broad.mit.edu	37	chr16	68729736	68729736	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccaggccggaggtggttctCcgcaatgacgtggcaccaac	8	6	14	13	3	1	1	0	1	1	0	2	2	1	2	4	5	1	3	4	5	2	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr16:68729736C>T	uc002ewf.2	+	15	3322	c.2190C>T	c.(2188-2190)CTC>CTT	p.L730L	CDH3_uc010vli.1_Silent_p.L675L	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	730	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		AGGTGGTTCTCCGCAATGACG	0.582													73	62					0	0	0	0	T	68729736	T	T	68729736	2	4	263	1	0	0	0	0	0	0	0	1	3126	842	30	2		2	CDH3	16	68729736	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	6870714	68729736	21625017	93	48043											
SF3B3	23450	broad.mit.edu	37	chr16	70590203	70590203	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggctgtggggcttgtggAcaacactgtcagaatcatct	8	11	12	10	0	3	1	2	0	1	1	3	2	3	2	1	4	1	2	1	4	2	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr16:70590203A>T	uc002ezf.2	+	14	2043	c.1832A>T	c.(1831-1833)GAC>GTC	p.D611V		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	611					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				GGGCTTGTGGACAACACTGTC	0.542													84	179					0	0	0	0	T	70590203	T	T	70590203	3	4	263	1	0	0	0	0	1	0	0	0	14217	275	10	5	1882	5	SF3B3	16	70590203	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	1860467	70590203	19764550	94	48044											
CALB2	794	broad.mit.edu	37	chr16	71423757	71423757	+	Frame_Shift_Del	DEL	C	-	-																															agattgtgctctgcagcgagCcccccatgtaaagtggggac																										TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr16:71423757delC	uc002faa.3	+	11	875	c.805delC	c.(805-807)CCCfs	p.P269fs	CALB2_uc010vme.1_RNA|CALB2_uc002fac.3_3'UTR	NM_001740	NP_001731	P22676	CALB2_HUMAN	calbindin 2 isoform 1	269	EF-hand 6.						calcium ion binding				0		Ovarian(137;0.125)				CTGCAGCGAGCCCCCCATGTA	0.587													---	---	---								-	71423757	-	-	71423757	7	5	263	1	0	1	0	1	0	0	0	0	2586	739	26	0	847	0	CALB2	16	71423757	Frame_Shift_Del	DEL	C	TCGA-CV-7430-01A-11D-2129-08	833554	71423757	18930996	95	48045											
CNTNAP4	85445	broad.mit.edu	37	chr16	76555134	76555134	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcggatgtatctttctttttTaagacaacagcttcatctgg	9	16	8	8	1	4	1	1	0	3	1	4	2	4	2	0	2	2	2	0	2	3	6			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr16:76555134T>C	uc002feu.1	+	18	2848	c.2463T>C	c.(2461-2463)TTT>TTC	p.F821F	CNTNAP4_uc002fev.1_Silent_p.F685F|CNTNAP4_uc010chb.1_Silent_p.F748F|CNTNAP4_uc002fex.1_Silent_p.F824F	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	821	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CTTTCTTTTTTAAGACAACAG	0.408													62	202					0	0	0	0	C	76555134	C	C	76555134	2	2	263	1	0	0	0	0	0	0	0	1	3664	1751	61	5		5	CNTNAP4	16	76555134	Silent	SNP	T	TCGA-CV-7430-01A-11D-2129-08	5131377	76555134	13799619	96	48046											
FBXO31	79791	broad.mit.edu	37	chr16	87376494	87376494	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggctcacctcctgcctccCgccggacatcctgtggtggt	3	10	12	16	2	1	0	1	0	0	0	4	1	4	1	6	4	1	1	6	4	0	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr16:87376494C>A	uc002fjw.2	-	5	765	c.721G>T	c.(721-723)GGG>TGG	p.G241W	FBXO31_uc010vot.1_Missense_Mutation_p.G69W|FBXO31_uc002fjv.2_Missense_Mutation_p.G133W	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	241					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		TCCTGCCTCCCGCCGGACATC	0.557													9	8					0.00621372	0.00657451	1	0	A	87376494	A	A	87376494	3	1	263	1	0	0	0	0	1	0	0	0	5773	652	23	3	918	3	FBXO31	16	87376494	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	10821360	87376494	2978259	97	48047											
ZC3H18	124245	broad.mit.edu	37	chr16	88689626	88689626	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctccgtcccgcccgccccaGgtcgtcttcgcggtcatcgt	2	9	11	19	7	2	0	1	0	1	0	7	0	4	0	5	2	0	1	5	2	0	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr16:88689626G>A	uc002fky.2	+	10	1868	c.1668_splice	c.e10-1	p.R556_splice	ZC3H18_uc010voz.1_Splice_Site_p.R580_splice|ZC3H18_uc010chw.2_Splice_Site	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18							nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		GCCCGCCCCAGGTCGTCTTCG	0.512													29	25					0	0	0	0	A	88689626	A	A	88689626	5	1	263	1	0	0	0	0	0	0	1	0	17635	1014	35	4	1701	4	ZC3H18	16	88689626	Splice_Site	SNP	G	TCGA-CV-7430-01A-11D-2129-08	1313132	88689626	1665127	98	48048											
TP53	7157	broad.mit.edu	37	chr17	7578553	7578553	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcttgttgagggcaggggagTactgtaggaagaggaaggag	11	8	19	3	0	1	2	0	1	1	1	1	6	1	6	0	6	1	4	0	6	4	4			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr17:7578553T>C	uc002gim.2	-	5	571	c.377A>G	c.(376-378)TAC>TGC	p.Y126C	TP53_uc002gig.1_Missense_Mutation_p.Y126C|TP53_uc002gih.2_Missense_Mutation_p.Y126C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.Y126C|TP53_uc010cni.1_Missense_Mutation_p.Y126C|TP53_uc002gij.2_Missense_Mutation_p.Y126C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y33C|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.Y87C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	126	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> C (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> G (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y126*(9)|p.0?(7)|p.Y126N(6)|p.Y126_K132delYSPALNK(6)|p.Y126C(4)|p.Y126D(3)|p.Y126_N131delYSPALN(3)|p.Y126S(2)|p.V73fs*9(1)|p.?(1)|p.Y126Y(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)|p.Y126fs*24(1)|p.Y126fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAGGGGAGTACTGTAGGAA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			44	10					0	0	0	0	C	7578553	C	C	7578553	3	2	263	1	0	0	0	0	1	0	0	0	16448	1652	57	5	921	5	TP53	17	7578553	Missense_Mutation	SNP	T	TCGA-CV-7430-01A-11D-2129-08		7578553	73616657	99	48049											
MYH4	4622	broad.mit.edu	37	chr17	10369589	10369589	+	Splice_Site	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcgttgaaagggtgctcaCgtagatcatccaggctgcgt	9	10	13	9	3	2	2	2	1	0	1	3	2	3	2	1	2	3	4	1	2	3	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr17:10369589C>A	uc002gmn.2	-	4	459	c.348_splice	c.e4+1	p.Y116_splice	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AGGGTGCTCACGTAGATCATC	0.433													43	85					1.56793e-16	1.79818e-16	1	0	A	10369589	A	A	10369589	5	1	263	1	0	0	0	0	0	0	1	0	10090	550	19	3	5618	3	MYH4	17	10369589	Splice_Site	SNP	C	TCGA-CV-7430-01A-11D-2129-08	2791036	10369589	70825621	100	48050											
ITGB3	3690	broad.mit.edu	37	chr17	45368453	45368453	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggactcaagattggagacaCggtgaggtgggctgggcagg	9	6	20	6	1	1	3	1	1	0	2	1	5	1	4	0	7	0	2	0	7	1	1	rs147758772		TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr17:45368453C>T	uc002ilj.2	+	9	1279	c.1259C>T	c.(1258-1260)ACG>ATG	p.T420M	ITGB3_uc002ili.1_Missense_Mutation_p.T420M|ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	420	Extracellular (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	ATTGGAGACACGGTGAGGTGG	0.542													30	84					0	0	0	0	T	45368453	T	T	45368453	3	4	263	1	0	0	0	0	1	0	0	0	7934	550	19	1	1293	1	ITGB3	17	45368453	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	34998864	45368453	35826757	101	48051											
KCNJ2	3759	broad.mit.edu	37	chr17	68171810	68171810	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagacggcaagctgtgtttGatgtggcgagtgggcaatct	9	10	16	6	2	1	2	0	1	1	1	1	4	1	2	0	3	1	4	0	3	2	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr17:68171810G>A	uc010dfg.2	+	2	1031	c.630G>A	c.(628-630)TTG>TTA	p.L210L	KCNJ2_uc002jir.2_Silent_p.L210L	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	210	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					AGCTGTGTTTGATGTGGCGAG	0.498													34	56					0	0	0	0	A	68171810	A	A	68171810	2	1	263	1	0	0	0	0	0	0	0	1	8090	1281	45	2		2	KCNJ2	17	68171810	Silent	SNP	G	TCGA-CV-7430-01A-11D-2129-08	22803357	68171810	13023400	102	48052											
CDR2L	30850	broad.mit.edu	37	chr17	72998278	72998278	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaagcgggaacgcaggcgtaCcatccacaccttcccctgcc	9	5	10	17	3	0	0	0	0	0	0	2	2	2	1	6	2	4	2	6	2	3	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr17:72998278C>T	uc002jml.3	+	4	873	c.461C>T	c.(460-462)ACC>ATC	p.T154I		NM_014603	NP_055418	Q86X02	CDR2L_HUMAN	cerebellar degeneration-related protein 2-like	154											0	all_lung(278;0.226)					CGCAGGCGTACCATCCACACC	0.647													10	14					0	0	0	0	T	72998278	T	T	72998278	3	4	263	1	0	0	0	0	1	0	0	0	3188	507	18	4	475	4	CDR2L	17	72998278	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	4826468	72998278	8196932	103	48053											
EVPL	2125	broad.mit.edu	37	chr17	74019475	74019475	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactccgcacactcctgggtCacccgctcgtgcagctgctt	5	10	9	17	3	1	0	1	0	0	0	4	0	3	0	3	1	4	5	3	1	1	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr17:74019475C>T	uc002jqi.2	-	4	606	c.378G>A	c.(376-378)GTG>GTA	p.V126V	EVPL_uc010wss.1_Silent_p.V126V|EVPL_uc010wst.1_5'UTR	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	126	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						ACTCCTGGGTCACCCGCTCGT	0.672													28	72					0	0	0	0	T	74019475	T	T	74019475	2	4	263	1	0	0	0	0	0	0	0	1	5316	813	29	2		2	EVPL	17	74019475	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	1021197	74019475	7175735	104	48054											
ZNF791	163049	broad.mit.edu	37	chr19	12735473	12735473	+	Frame_Shift_Del	DEL	G	-	-																															ctacattttaggggaaaaatGggaagacccgaatgttgaag																										TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr19:12735473delG	uc002mua.2	+	3	302	c.140delG	c.(139-141)TGGfs	p.W47fs	ZNF791_uc010xml.1_Frame_Shift_Del_p.W15fs|ZNF791_uc010dyu.1_Intron|ZNF791_uc010xmm.1_Translation_Start_Site	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGGGAAAAATGGGAAGACCCG	0.313													---	---	---								-	12735473	-	-	12735473	7	5	263	1	0	1	0	1	0	0	0	0	18230	1357	47	0	150	0	ZNF791	19	12735473	Frame_Shift_Del	DEL	G	TCGA-CV-7430-01A-11D-2129-08		12735473	46393510	105	48055											
MAST1	22983	broad.mit.edu	37	chr19	12975624	12975624	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatttcctggcctgcaggCggcgactgtgccaccctgct	4	9	11	17	2	0	0	0	0	0	0	1	1	1	0	5	3	3	2	5	3	0	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr19:12975624C>T	uc002mvm.2	+	13	1496	c.1368C>T	c.(1366-1368)GGC>GGT	p.G456G		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	456	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						GGCCTGCAGGCGGCGACTGTG	0.507													19	36					0	0	0	0	T	12975624	T	T	12975624	2	4	263	1	0	0	0	0	0	0	0	1	9377	782	27	1		1	MAST1	19	12975624	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	240151	12975624	46153359	106	48056											
SLC5A5	6528	broad.mit.edu	37	chr19	18001748	18001748	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgtggtgggacctcgcaCggcagacagcatcagtggcc	7	8	15	11	2	1	1	1	0	0	1	2	2	1	2	2	4	1	4	2	4	0	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr19:18001748C>T	uc002nhr.3	+	14	2052	c.1705C>T	c.(1705-1707)CGG>TGG	p.R569W		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	569	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GGACCTCGCACGGCAGACAGC	0.602													75	130					0	0	0	0	T	18001748	T	T	18001748	3	4	263	1	0	0	0	0	1	0	0	0	14732	527	19	1	1759	1	SLC5A5	19	18001748	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	5026124	18001748	41127235	107	48057											
C19orf2	8725	broad.mit.edu	37	chr19	30433493	30433494	+	Frame_Shift_Ins	INS	-	C	C																															agacgccccccgacccctcgINScccccttcggccccggcccc																										TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr19:30433493_30433494insC	uc002nsr.2	+	1	69_70	c.39_40insC	c.(37-42)TCGCCCfs	p.S13fs	C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_5'UTR	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	13_14					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		CCGACCCCTCGCCCCCTTCGGC	0.762													---	---	---								C	30433494	C	C	30433493	7	5	263	1	0	1	1	0	0	0	0	0	1920	1074	38	0	41	0	C19orf2	19	30433493	Frame_Shift_Ins	INS	-	TCGA-CV-7430-01A-11D-2129-08	12431745	30433493	28695490	108	48058											
ZNF285	26974	broad.mit.edu	37	chr19	44890792	44890792	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acatgccttacacttataggGcctctctcttgtgtggactc	7	14	8	12	0	2	0	0	0	2	0	4	1	2	1	2	2	2	0	2	2	3	4			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr19:44890792G>C	uc002ozd.3	-	4	1702	c.1615C>G	c.(1615-1617)CCC>GCC	p.P539A	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.P546A	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	539					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						CACTTATAGGGCCTCTCTCTT	0.438													39	19					0	0	0	0	C	44890792	C	C	44890792	3	2	263	1	0	0	0	0	1	0	0	0	17889	1203	42	4	161	4	ZNF285	19	44890792	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	14457299	44890792	14238191	109	48059											
FAM83E	54854	broad.mit.edu	37	chr19	49116610	49116610	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccactccttccagcgccGccagctgggaggccgccatc	6	6	11	18	3	0	0	0	0	0	0	4	1	3	1	7	2	2	1	7	2	0	1			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	268e0e78-73a5-43f9-a25f-cd862c4438bd	g.chr19:49116610G>A	uc002pjn.2	-	1	85	c.20C>T	c.(19-21)GCG>GTG	p.A7V		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	7										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		TTCCAGCGCCGCCAGCTGGGA	0.682													3	2					0	0	0	0	A	49116610	A	A	49116610	3	1	263	1	0	0	0	0	1	0	0	0	5669	1087	38	1	1436	1	FAM83E	19	49116610	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	4225818	49116610	10012373	110	48060											
ZNF83	55769	broad.mit.edu	37	chr19	53117347	53117347	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgtgacatattatggaaGaccttgccacattcattaca	13	12	8	8	0	1	2	1	1	0	1	1	3	1	3	2	2	2	0	2	2	4	5			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr19:53117347G>A	uc002pzu.3	-	2	1715	c.471C>T	c.(469-471)GTC>GTT	p.V157V	ZNF83_uc002pzv.3_Silent_p.V157V|ZNF83_uc010eps.2_Silent_p.V157V|ZNF83_uc010ept.2_Silent_p.V157V|ZNF83_uc010epu.2_Silent_p.V157V|ZNF83_uc010epv.2_Silent_p.V157V|ZNF83_uc010epw.2_Silent_p.V157V|ZNF83_uc010epx.2_Silent_p.V157V|ZNF83_uc010epy.2_Silent_p.V157V|ZNF83_uc010epz.2_Silent_p.V157V|ZNF83_uc010eqb.1_Silent_p.V157V	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	157	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		TATTATGGAAGACCTTGCCAC	0.353													16	25					0	0	0	0	A	53117347	A	A	53117347	2	1	263	1	0	0	0	0	0	0	0	1	18250	929	33	2		2	ZNF83	19	53117347	Silent	SNP	G	TCGA-CV-7430-01A-11D-2129-08	4000737	53117347	6011636	111	48061											
LILRA4	23547	broad.mit.edu	37	chr19	54850163	54850163	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacccgggtcctggggcccAggctcagccctggaagagag	7	4	16	14	1	1	1	1	0	0	1	2	3	2	2	4	5	1	2	4	5	1	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr19:54850163A>G	uc002qfj.2	-	2	101	c.44T>C	c.(43-45)CTG>CCG	p.L15P	LILRA4_uc002qfi.2_5'UTR	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	15						integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CCTGGGGCCCAGGCTCAGCCC	0.622											OREG0003656	type=REGULATORY REGION|Gene=LILRA4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	25	22					0	0	0	0	G	54850163	G	G	54850163	3	3	263	1	0	0	0	0	1	0	0	0	8828	188	7	5	1483	5	LILRA4	19	54850163	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	1732816	54850163	4278820	112	48062											
RNF24	11237	broad.mit.edu	37	chr20	3914726	3914726	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagctatacaatgttctctGccccaggaaggggcccctga	10	9	10	12	0	1	1	0	1	1	0	2	2	1	2	4	3	3	2	4	3	5	4			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr20:3914726G>A	uc002wkh.2	-	6	701	c.431C>T	c.(430-432)GCA>GTA	p.A144V	RNF24_uc002wki.2_Missense_Mutation_p.A165V|RNF24_uc002wkj.2_Missense_Mutation_p.A144V	NM_007219	NP_009150	Q9Y225	RNF24_HUMAN	ring finger protein 24 isoform 1	144						Golgi membrane|integral to membrane	zinc ion binding				0						AATGTTCTCTGCCCCAGGAAG	0.562													67	102					0	0	0	0	A	3914726	A	A	3914726	3	1	263	1	0	0	0	0	1	0	0	0	13549	1319	46	4	19	4	RNF24	20	3914726	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08		3914726	59110794	113	48063											
PHACTR3	116154	broad.mit.edu	37	chr20	58349395	58349395	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggggcaaggagagggaggagGcttggagctttgacggggca	9	5	22	5	1	0	2	0	1	0	1	0	6	0	5	0	9	1	4	0	9	1	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr20:58349395G>C	uc002yau.2	+	7	1491	c.1024G>C	c.(1024-1026)GCT>CCT	p.A342P	PHACTR3_uc002yat.2_Missense_Mutation_p.A339P|PHACTR3_uc010zzw.1_Missense_Mutation_p.A301P|PHACTR3_uc002yav.2_Missense_Mutation_p.A301P|PHACTR3_uc002yaw.2_Missense_Mutation_p.A301P|PHACTR3_uc002yax.2_Missense_Mutation_p.A231P	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	342						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GAGGGAGGAGGCTTGGAGCTT	0.512													35	48					0	0	0	0	C	58349395	C	C	58349395	3	2	263	1	0	0	0	0	1	0	0	0	11866	1203	42	4	1050	4	PHACTR3	20	58349395	Missense_Mutation	SNP	G	TCGA-CV-7430-01A-11D-2129-08	54434669	58349395	4676125	114	48064											
TCFL5	10732	broad.mit.edu	37	chr20	61488812	61488812	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcctccctggggcccactCtgggcctgctcccccaggtt	2	10	10	19	0	1	0	0	0	1	0	4	0	4	0	6	4	1	2	6	4	0	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr20:61488812C>T	uc002ydp.2	-	4	1266	c.1173G>A	c.(1171-1173)CAG>CAA	p.Q391Q	TCFL5_uc002ydo.2_Silent_p.Q164Q|TCFL5_uc002ydq.2_Silent_p.Q390Q	NM_006602	NP_006593	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 protein	391					cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)	1	Breast(26;5.68e-08)					GGGGCCCACTCTGGGCCTGCT	0.572													166	49					0	0	0	0	T	61488812	T	T	61488812	2	4	263	1	0	0	0	0	0	0	0	1	15765	912	32	2		2	TCFL5	20	61488812	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08	3139417	61488812	1536708	115	48065											
DSCAM	1826	broad.mit.edu	37	chr21	41684252	41684252	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccgctgcccaatggagaaTcttggaaactcaaagggttg	12	8	11	10	1	2	1	1	0	1	1	2	3	2	2	2	3	2	2	2	3	4	2			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr21:41684252T>C	uc002yyq.1	-	9	2270	c.1818A>G	c.(1816-1818)AGA>AGG	p.R606R	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	606	Extracellular (Potential).|Ig-like C2-type 7.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CAATGGAGAATCTTGGAAACT	0.478													16	29					0	0	0	0	C	41684252	C	C	41684252	2	2	263	1	0	0	0	0	0	0	0	1	4790	1432	50	5		5	DSCAM	21	41684252	Silent	SNP	T	TCGA-CV-7430-01A-11D-2129-08		41684252	6445643	116	48066											
MYO18B	84700	broad.mit.edu	37	chr22	26242142	26242142	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtggcaggcctggagggCacctcccagcaggccctgca	6	5	15	15	0	0	0	0	0	0	0	1	1	1	1	4	5	2	5	4	5	0	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr22:26242142C>G	uc003abz.1	+	19	3694	c.3444C>G	c.(3442-3444)GGC>GGG	p.G1148G	MYO18B_uc003aca.1_Silent_p.G1029G|MYO18B_uc010guy.1_Silent_p.G1030G|MYO18B_uc010guz.1_Silent_p.G1029G|MYO18B_uc011aka.1_Silent_p.G302G|MYO18B_uc011akb.1_Silent_p.G661G	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1148	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GCCTGGAGGGCACCTCCCAGC	0.667													10	23					0	0	0	0	G	26242142	G	G	26242142	2	3	263	1	0	0	0	0	0	0	0	1	10119	697	25	4		4	MYO18B	22	26242142	Silent	SNP	C	TCGA-CV-7430-01A-11D-2129-08		26242142	25062424	117	48067											
ADM2	79924	broad.mit.edu	37	chr22	50921172	50921172	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcgggcccccgaagacactCgggcccccgcaggacccaag	8	2	12	19	4	0	1	0	0	0	1	2	3	0	2	5	3	0	1	5	3	2	0			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chr22:50921172C>T	uc003blj.2	+	2	552	c.287C>T	c.(286-288)TCG>TTG	p.S96L	ADM2_uc011ary.1_Missense_Mutation_p.S96L	NM_024866	NP_079142	Q7Z4H4	ADM2_HUMAN	adrenomedullin 2 precursor	96					positive regulation of angiogenesis	extracellular region	hormone activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGAAGACACTCGGGCCCCCGC	0.697													18	11					0	0	0	0	T	50921172	T	T	50921172	3	4	263	1	0	0	0	0	1	0	0	0	322	893	31	1	293	1	ADM2	22	50921172	Missense_Mutation	SNP	C	TCGA-CV-7430-01A-11D-2129-08	24679030	50921172	383394	118	48068											
CNKSR2	22866	broad.mit.edu	37	chrX	21515965	21515965	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttactggaaccacagaaaatGtaagtattctaacctttcaa	16	12	5	8	0	2	1	1	0	1	1	2	2	2	2	2	1	3	2	2	1	8	6			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chrX:21515965G>A	uc004czx.1	+	7	777	c.741_splice	c.e7+1	p.N247_splice	CNKSR2_uc004czw.2_Splice_Site_p.N247_splice|CNKSR2_uc011mjn.1_Splice_Site_p.N247_splice|CNKSR2_uc011mjo.1_Splice_Site_p.N247_splice	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras						regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						CACAGAAAATGTAAGTATTCT	0.308													22	10					0	0	0	0	A	21515965	A	A	21515965	5	1	263	1	0	0	0	0	0	0	1	0	3622	1391	48	4	768	4	CNKSR2	23	21515965	Splice_Site	SNP	G	TCGA-CV-7430-01A-11D-2129-08		21515965	133754595	119	48069											
NXF3	56000	broad.mit.edu	37	chrX	102337236	102337236	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactgggcttctgtccgcAcacttctctcctggctctat	5	13	7	16	1	3	0	0	0	3	0	6	0	5	0	2	2	0	3	2	2	1	3			TCGA-CV-7430-01A-11D-2129-08	TCGA-CV-7430-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	29a4027f-4d4f-4133-b40a-3bfab6d2ac9e	9c201383-26e2-4f85-b60e-8142f545c2e3	g.chrX:102337236A>C	uc004eju.2	-	9	908	c.837T>G	c.(835-837)TGT>TGG	p.C279W	NXF3_uc010noi.1_Missense_Mutation_p.C129W|NXF3_uc011mrw.1_Missense_Mutation_p.C279W|NXF3_uc011mrx.1_Missense_Mutation_p.C190W	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	279						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						TTCTGTCCGCACACTTCTCTC	0.532													11	129					0	0	0	0	C	102337236	C	C	102337236	3	2	263	1	0	0	0	0	1	0	0	0	10839	157	6	5	802	5	NXF3	23	102337236	Missense_Mutation	SNP	A	TCGA-CV-7430-01A-11D-2129-08	80821271	102337236	52933324	120	48070											
KIAA1522	57648	broad.mit.edu	37	chr1	33237322	33237322	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccagctcctgctagttccGccccagggcatgtggccaag	6	7	11	17	1	0	0	0	0	0	0	2	0	2	0	7	2	2	4	7	2	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:33237322G>A	uc001bvv.2	+	6	2501	c.2365G>A	c.(2365-2367)GCC>ACC	p.A789T	KIAA1522_uc001bvu.1_Missense_Mutation_p.A848T|KIAA1522_uc010ohm.1_Missense_Mutation_p.A800T|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	789	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TGCTAGTTCCGCCCCAGGGCA	0.677													3	31					0	0	0	0	A	33237322	A	A	33237322	3	1	264	1	0	0	0	0	1	0	0	0	8277	1087	38	1	2564	1	KIAA1522	1	33237322	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08		33237322	216013299	1	48071											
C1orf87	127795	broad.mit.edu	37	chr1	60503714	60503714	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttctcaggtctgcagctgcTttattttgctgtggataatc	6	18	9	8	0	2	0	1	0	2	0	4	1	2	1	0	2	4	4	0	2	2	6			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:60503714T>A	uc001czs.1	-	6	905	c.813A>T	c.(811-813)AAA>AAT	p.K271N		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	271							calcium ion binding			ovary(1)|breast(1)	2						CTGCAGCTGCTTTATTTTGCT	0.358													19	38					0	0	0	0	A	60503714	A	A	60503714	3	1	264	1	0	0	0	0	1	0	0	0	2074	1606	56	5	855	5	C1orf87	1	60503714	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	27266392	60503714	188746907	2	48072											
BRDT	676	broad.mit.edu	37	chr1	92459659	92459659	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gataggatattgtgtgcaagAcacaacctctgccaatacta	14	10	8	9	0	1	1	0	0	1	1	1	3	1	2	2	1	4	1	2	1	7	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:92459659A>G	uc001dok.3	+	15	2484	c.2135A>G	c.(2134-2136)GAC>GGC	p.D712G	BRDT_uc001dol.3_Missense_Mutation_p.D712G|BRDT_uc010osz.1_Missense_Mutation_p.D716G|BRDT_uc009wdf.2_Missense_Mutation_p.D639G|BRDT_uc010ota.1_Missense_Mutation_p.D666G|BRDT_uc010otb.1_Missense_Mutation_p.D666G|BRDT_uc001dom.3_Missense_Mutation_p.D712G	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	712					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		TGTGTGCAAGACACAACCTCT	0.348													41	76					0	0	0	0	G	92459659	G	G	92459659	3	3	264	1	0	0	0	0	1	0	0	0	1513	275	10	5	2189	5	BRDT	1	92459659	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	31955945	92459659	156790962	3	48073											
DENND2C	163259	broad.mit.edu	37	chr1	115078685	115078685	+	RNA	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctacatgcagccacggctGacacattcctggagcacatg	11	7	10	13	1	0	1	0	1	0	0	1	2	1	2	2	2	5	4	2	2	1	2	rs2137365	by1000genomes	TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:115078685G>C	uc001eez.2	-	29		c.4958C>G				NM_198459		Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C											skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGCCACGGCTGACACATTCCT	0.562													3	25					0	0	0	0	C	115078685	C	C	115078685	1	2	264	0	1	0	0	0	0	0	0	0	4452	1305	45	2		2	DENND2C	1	115078685	RNA	SNP	G	TCGA-CV-7432-01A-11D-2129-08	22619026	115078685	134171936	4	48074											
NBPF7	343505	broad.mit.edu	37	chr1	120387065	120387065	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaatgttcatctctgcttTctcactggaccaggggccgg	7	12	11	11	1	3	1	2	0	2	1	5	2	3	2	2	4	1	2	2	4	2	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:120387065T>A	uc010oxk.1	-	1	715	c.94A>T	c.(94-96)AAA>TAA	p.K32*		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	32						cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		ATCTCTGCTTTCTCACTGGAC	0.488											OREG0013730	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	122					0	0	0	0	A	120387065	A	A	120387065	4	1	264	1	0	0	0	0	0	1	0	0	10252	1792	62	5	1202	5	NBPF7	1	120387065	Nonsense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	5308380	120387065	128863556	5	48075											
KIAA0907	22889	broad.mit.edu	37	chr1	155891296	155891296	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtggcactatgcttggtactCcgtagggaggttgaactggc	7	11	15	8	1	0	1	0	1	0	0	1	2	1	2	1	5	3	5	1	5	4	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:155891296C>T	uc001fmi.1	-	10	1160	c.1136G>A	c.(1135-1137)GGA>GAA	p.G379E	KIAA0907_uc001fmj.1_Missense_Mutation_p.G379E|KIAA0907_uc009wrk.1_Missense_Mutation_p.G236E|KIAA0907_uc009wrl.1_RNA|SNORA42_uc001fmk.1_5'Flank|KIAA0907_uc001fml.1_Silent_p.R345R	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	379	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			GCTTGGTACTCCGTAGGGAGG	0.517													25	63					0	0	0	0	T	155891296	T	T	155891296	3	4	264	1	0	0	0	0	1	0	0	0	8238	855	30	2	728	2	KIAA0907	1	155891296	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	35504231	155891296	93359325	6	48076											
OR10K1	391109	broad.mit.edu	37	chr1	158435777	158435777	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgggacatggggtgtgtatGggactaatggctgctgcctg	7	11	17	6	0	0	0	0	0	0	0	0	2	0	2	1	5	2	3	1	5	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:158435777G>A	uc010pij.1	+	1	426	c.426G>A	c.(424-426)ATG>ATA	p.M142I		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GGGTGTGTATGGGACTAATGG	0.562													62	121					0	0	0	0	A	158435777	A	A	158435777	3	1	264	1	0	0	0	0	1	0	0	0	10967	1348	47	4	428	4	OR10K1	1	158435777	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	2544481	158435777	90814844	7	48077											
TNN	63923	broad.mit.edu	37	chr1	175063297	175063297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagagcagcactgtcctgaCgggcctgaagccaggagagg	10	5	16	10	1	0	4	0	3	0	2	1	6	1	4	3	3	3	2	3	3	1	0	rs17374761		TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:175063297C>T	uc001gkl.1	+	7	1609	c.1496C>T	c.(1495-1497)ACG>ATG	p.T499M	TNN_uc010pmx.1_Missense_Mutation_p.T499M	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	499	Fibronectin type-III 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACTGTCCTGACGGGCCTGAAG	0.547													16	32					0	0	0	0	T	175063297	T	T	175063297	3	4	264	1	0	0	0	0	1	0	0	0	16389	536	19	1	1518	1	TNN	1	175063297	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	16627520	175063297	74187324	8	48078											
SLC41A1	254428	broad.mit.edu	37	chr1	205764562	205764562	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccattcatgtgcaggaaggTggagatgcggctggcctgca	8	9	15	9	1	1	1	1	0	0	1	2	3	2	2	2	5	3	3	2	5	1	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:205764562T>A	uc001hdh.1	-	9	1989	c.1117A>T	c.(1117-1119)ACC>TCC	p.T373S	SLC41A1_uc001hdg.1_5'UTR	NM_173854	NP_776253	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 member 1	373						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			skin(2)	2	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			TGCAGGAAGGTGGAGATGCGG	0.587													19	29					0	0	0	0	A	205764562	A	A	205764562	3	1	264	1	0	0	0	0	1	0	0	0	14693	1696	59	5	436	5	SLC41A1	1	205764562	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	30701265	205764562	43486059	9	48079											
RYR2	6262	broad.mit.edu	37	chr1	237982376	237982376	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgttggagttcgtgctggagGagggatcggggatgaaatcg	8	10	19	4	3	0	1	0	1	0	0	3	6	0	6	0	6	1	3	0	6	1	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:237982376G>A	uc001hyl.1	+	101	14594	c.14474G>A	c.(14473-14475)GGA>GAA	p.G4825E	RYR2_uc010pyb.1_Missense_Mutation_p.G258E	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4825	Helical; Name=M9; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGTGCTGGAGGAGGGATCGGG	0.408													15	37					0	0	0	0	A	237982376	A	A	237982376	3	1	264	1	0	0	0	0	1	0	0	0	13834	1174	41	2	14876	2	RYR2	1	237982376	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	32217814	237982376	11268245	10	48080											
RGS7	6000	broad.mit.edu	37	chr1	240975267	240975267	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagaaatttaaggaactgttCtctcccaactgggtctttca	11	14	7	9	0	3	1	1	0	2	1	5	2	4	2	1	2	2	1	1	2	5	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr1:240975267C>A	uc001hyv.2	-	14	1363	c.1033G>T	c.(1033-1035)GAA>TAA	p.E345*	RGS7_uc010pyh.1_Nonsense_Mutation_p.E319*|RGS7_uc010pyj.1_Nonsense_Mutation_p.E261*|RGS7_uc001hyu.2_Nonsense_Mutation_p.E345*|RGS7_uc009xgn.1_Nonsense_Mutation_p.E292*|RGS7_uc001hyw.2_Nonsense_Mutation_p.E345*|RGS7_uc001hyt.2_Nonsense_Mutation_p.E177*	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	345	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			AGGAACTGTTCTCTCCCAACT	0.413													33	84					4.3181e-19	5.15309e-19	1	0	A	240975267	A	A	240975267	4	1	264	1	0	0	0	0	0	1	0	0	13375	922	32	2	450	2	RGS7	1	240975267	Nonsense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	2992891	240975267	8275354	11	48081											
REG3G	130120	broad.mit.edu	37	chr2	79255001	79255001	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaattactttgcatgggaGaaaaatccctccaccatctt	13	12	6	10	0	1	2	0	1	1	1	3	3	3	2	3	1	2	1	3	1	4	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:79255001G>A	uc002snw.2	+	5	487	c.402G>A	c.(400-402)GAG>GAA	p.E134E	REG3G_uc002snx.2_Silent_p.E134E|REG3G_uc010ffu.2_Silent_p.E88E	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	134	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						TTGCATGGGAGAAAAATCCCT	0.507													36	41					0	0	0	0	A	79255001	A	A	79255001	2	1	264	1	0	0	0	0	0	0	0	1	13278	933	33	2		2	REG3G	2	79255001	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08		79255001	163944372	12	48082											
FOXD4L1	200350	broad.mit.edu	37	chr2	114257667	114257667	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctcggcccccgcctatgcCggggcaccgaagaaagcaga	9	4	12	16	4	1	2	0	0	1	2	2	3	1	2	5	3	2	2	5	3	3	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:114257667C>A	uc002tjw.3	+	1	1007	c.834C>A	c.(832-834)GCC>GCA	p.A278A		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	278	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CCGCCTATGCCGGGGCACCGA	0.701													24	29					2.61193e-14	3.00094e-14	1	0	A	114257667	A	A	114257667	2	1	264	1	0	0	0	0	0	0	0	1	6032	639	23	3		3	FOXD4L1	2	114257667	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	35002666	114257667	128941706	13	48083											
DPP10	57628	broad.mit.edu	37	chr2	116485420	116485420	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttgaaaataatatctactAtcaacctgatataaagagca	18	13	4	6	0	2	3	1	2	1	1	2	3	2	3	1	0	3	1	1	0	10	8			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:116485420A>G	uc002tla.1	+	8	1062	c.605A>G	c.(604-606)TAT>TGT	p.Y202C	DPP10_uc002tlb.1_Missense_Mutation_p.Y152C|DPP10_uc002tlc.1_Missense_Mutation_p.Y198C|DPP10_uc002tle.2_Missense_Mutation_p.Y206C|DPP10_uc002tlf.1_Missense_Mutation_p.Y195C	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	202	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AATATCTACTATCAACCTGAT	0.313													7	32					0	0	0	0	G	116485420	G	G	116485420	3	3	264	1	0	0	0	0	1	0	0	0	4749	449	16	5	806	5	DPP10	2	116485420	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	2227753	116485420	126713953	14	48084											
LRP1B	53353	broad.mit.edu	37	chr2	141771236	141771236	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgaaaaatggaaccattcaTataatcagtccagaacacat	18	10	5	8	0	2	2	2	1	0	1	3	3	3	3	2	1	2	0	2	1	6	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:141771236T>G	uc002tvj.1	-	14	3241	c.2269A>C	c.(2269-2271)ATG>CTG	p.M757L	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	757	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAACCATTCATATAATCAGTC	0.393										TSP Lung(27;0.18)			33	78					0	0	0	0	G	141771236	G	G	141771236	3	3	264	1	0	0	0	0	1	0	0	0	9005	1406	49	5	11842	5	LRP1B	2	141771236	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	25285816	141771236	101428137	15	48085											
GALNT13	114805	broad.mit.edu	37	chr2	155102432	155102432	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taactggaaactgaatttccGctggtatcctgttccccaaa	11	12	7	11	1	0	1	0	1	0	0	3	2	3	2	4	2	2	3	4	2	5	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:155102432G>A	uc002tyr.3	+	7	1361	c.794G>A	c.(793-795)CGC>CAC	p.R265H	GALNT13_uc002tyt.3_Missense_Mutation_p.R265H|GALNT13_uc010foc.1_Missense_Mutation_p.R84H|GALNT13_uc010fod.2_Missense_Mutation_p.R18H	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	265	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CTGAATTTCCGCTGGTATCCT	0.403													22	47					0	0	0	0	A	155102432	A	A	155102432	3	1	264	1	0	0	0	0	1	0	0	0	6246	1087	38	1	812	1	GALNT13	2	155102432	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	13331196	155102432	88096941	16	48086											
SCN1A	6323	broad.mit.edu	37	chr2	166852534	166852534	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acttcttactcctggtcgagGtataggcttttgcggttttt	5	18	10	8	2	1	0	0	0	1	0	3	1	2	0	1	4	2	3	1	4	3	8	rs143088184		TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:166852534G>T	uc010zcz.1	-	24	4555	c.4537C>A	c.(4537-4539)CCT>ACT	p.P1513T		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1524	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCTGGTCGAGGTATAGGCTTT	0.338													22	69					2.39556e-15	2.78195e-15	1	0	T	166852534	T	T	166852534	3	4	264	1	0	0	0	0	1	0	0	0	13979	1261	44	4	1471	4	SCN1A	2	166852534	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	11750102	166852534	76346839	17	48087											
LRP2	4036	broad.mit.edu	37	chr2	170063445	170063445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagagttctctccattgataCgaatccttgcaattatatct	11	15	5	10	1	2	2	0	1	2	1	5	3	4	2	2	0	2	2	2	0	5	6			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:170063445C>T	uc002ues.2	-	39	6998	c.6785G>A	c.(6784-6786)CGT>CAT	p.R2262H		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2262	LDL-receptor class B 23.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCCATTGATACGAATCCTTGC	0.433													35	107					0	0	0	0	T	170063445	T	T	170063445	3	4	264	1	0	0	0	0	1	0	0	0	9006	536	19	1	7346	1	LRP2	2	170063445	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	3210911	170063445	73135928	18	48088											
TLK1	9874	broad.mit.edu	37	chr2	171853218	171853224	+	Frame_Shift_Del	DEL	AATATTG	-	-																															actggacttctgtggcttttAatattgtattttcttgaaga																										TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:171853218_171853224delAATATTG	uc002ugn.2	-	20	2535_2541	c.2063_2069delCAATATT	c.(2062-2070)ACAATATTAfs	p.T688fs	TLK1_uc002ugo.2_Frame_Shift_Del_p.T709fs|TLK1_uc002ugp.2_Frame_Shift_Del_p.T640fs|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Frame_Shift_Del_p.T592fs	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	688_690	Protein kinase.				cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						TGTGGCTTTTAATATTGTATTTTCTTG	0.3													---	---	---								-	171853224	-	-	171853218	7	5	264	1	0	1	0	1	0	0	0	0	16009	372	13	0	239	0	TLK1	2	171853218	Frame_Shift_Del	DEL	AATATTG	TCGA-CV-7432-01A-11D-2129-08	1789773	171853218	71346155	19	48089											
TTN	7273	broad.mit.edu	37	chr2	179457503	179457503	+	Frame_Shift_Del	DEL	A	-	-																															gtgagagcattttactcaccAagcctgtcttttactaggac																										TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:179457503delA	uc010zfg.1	-	249	51863	c.51639delT	c.(51637-51639)CTTfs	p.L17213fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Del_p.L10908fs|TTN_uc010zfi.1_Frame_Shift_Del_p.L10841fs|TTN_uc010zfj.1_Frame_Shift_Del_p.L10716fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18140							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTACTCACCAAGCCTGTCTT	0.413													---	---	---								-	179457503	-	-	179457503	7	5	264	1	0	1	0	1	0	0	0	0	16803	144	5	0	48888	0	TTN	2	179457503	Frame_Shift_Del	DEL	A	TCGA-CV-7432-01A-11D-2129-08	7604285	179457503	63741870	20	48090											
TTN	7273	broad.mit.edu	37	chr2	179587087	179587087	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtcagtttgcaaaatttttAaagttgccacattatctaca	14	15	5	7	0	2	0	1	0	1	0	2	0	2	0	1	0	3	3	1	0	6	7			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:179587087A>G	uc010zfg.1	-	74	18919	c.18695T>C	c.(18694-18696)TTA>TCA	p.L6232S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.L2893S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7159							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAAATTTTTAAAGTTGCCAC	0.423													13	28					0	0	0	0	G	179587087	G	G	179587087	3	3	264	1	0	0	0	0	1	0	0	0	16803	372	13	5	82246	5	TTN	2	179587087	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	129584	179587087	63612286	21	48091											
CCDC108	255101	broad.mit.edu	37	chr2	219886544	219886544	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcagggctgccctgctccaGgtagaggcggtaatagaggg	8	7	16	10	1	1	2	1	0	0	2	2	2	2	2	2	5	2	4	2	5	3	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:219886544G>T	uc002vjl.1	-	18	3172	c.3088C>A	c.(3088-3090)CTG>ATG	p.L1030M	CCDC108_uc002vjm.3_5'Flank	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	1030						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCTGCTCCAGGTAGAGGCGG	0.602													79	114					2.43828e-56	2.99244e-56	1	0	T	219886544	T	T	219886544	3	4	264	1	0	0	0	0	1	0	0	0	2755	991	35	4	2761	4	CCDC108	2	219886544	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	40299457	219886544	23312829	22	48092											
COL4A3	1285	broad.mit.edu	37	chr2	228148997	228148997	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagggggaacaaggagataaAggaaatcccgggccttcaga	16	4	14	7	1	1	2	1	0	0	2	2	5	2	4	2	5	1	0	2	5	6	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:228148997A>G	uc002vom.1	+	34	2979	c.2817A>G	c.(2815-2817)AAA>AAG	p.K939K	COL4A3_uc002von.1_Silent_p.K939K|COL4A3_uc002voo.1_Silent_p.K939K|COL4A3_uc002vop.1_Silent_p.K939K|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	939	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AAGGAGATAAAGGAAATCCCG	0.458													13	30					0	0	0	0	G	228148997	G	G	228148997	2	3	264	1	0	0	0	0	0	0	0	1	3706	69	3	5		5	COL4A3	2	228148997	Silent	SNP	A	TCGA-CV-7432-01A-11D-2129-08	8262453	228148997	15050376	23	48093											
ILKAP	80895	broad.mit.edu	37	chr2	239090740	239090740	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agccttctgtatcctcatccGctcttcatactgagttggat	7	15	7	12	1	4	1	2	1	2	0	6	2	6	2	3	1	2	3	3	1	2	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr2:239090740G>T	uc002vxv.2	-	9	932	c.802C>A	c.(802-804)CGG>AGG	p.R268R	ILKAP_uc010zns.1_Silent_p.R200R|ILKAP_uc002vxw.2_Silent_p.R148R|ILKAP_uc010znt.1_Silent_p.R148R	NM_030768	NP_110395	Q9H0C8	ILKAP_HUMAN	integrin-linked kinase-associated protein	268	PP2C-like.					cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			ovary(3)	3		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)		ATCCTCATCCGCTCTTCATAC	0.498													84	187					2.56433e-40	3.12935e-40	1	0	T	239090740	T	T	239090740	2	4	264	1	0	0	0	0	0	0	0	1	7753	1086	38	3		3	ILKAP	2	239090740	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	10941743	239090740	4108633	24	48094											
NUP210	23225	broad.mit.edu	37	chr3	13370375	13370375	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcattcccaaaggcacggcCaccagggcctccttgttctg	7	9	10	15	1	2	0	1	0	1	0	4	0	4	0	5	3	0	2	5	3	1	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr3:13370375C>T	uc003bxv.1	-	31	4265	c.4182G>A	c.(4180-4182)GTG>GTA	p.V1394V		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1394	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					AAGGCACGGCCACCAGGGCCT	0.537													26	19					0	0	0	0	T	13370375	T	T	13370375	2	4	264	1	0	0	0	0	0	0	0	1	10814	581	21	4		4	NUP210	3	13370375	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08		13370375	184652055	25	48095											
PTPRG	5793	broad.mit.edu	37	chr3	62254758	62254758	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaacagtgaggaatatggaAacattattgtcacgctgaag	16	9	11	5	1	1	3	1	2	0	1	1	5	1	5	0	2	2	1	0	2	6	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr3:62254758A>G	uc003dlb.2	+	20	3642	c.2923A>G	c.(2923-2925)AAC>GAC	p.N975D	PTPRG_uc003dlc.2_Missense_Mutation_p.N946D|PTPRG_uc011bfi.1_Missense_Mutation_p.N221D|uc010hno.2_Intron|uc003dld.3_Intron|uc010hnp.2_Intron|uc003dle.3_Intron	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	975	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		GGAATATGGAAACATTATTGT	0.363													28	20					0	0	0	0	G	62254758	G	G	62254758	3	3	264	1	0	0	0	0	1	0	0	0	12867	14	1	5	3001	5	PTPRG	3	62254758	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	48884383	62254758	135767672	26	48096											
EPHA3	2042	broad.mit.edu	37	chr3	89390133	89390133	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctaagtgcccgcctcacagTtctactcaggaagatggttc	9	10	10	12	1	3	1	2	0	1	1	4	2	3	2	2	2	2	3	2	2	3	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr3:89390133T>G	uc003dqy.2	+	4	1107	c.882T>G	c.(880-882)AGT>AGG	p.S294R	EPHA3_uc003dqx.1_Missense_Mutation_p.S294R|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	294	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CGCCTCACAGTTCTACTCAGG	0.443										TSP Lung(6;0.00050)			30	84					0	0	0	0	G	89390133	G	G	89390133	3	3	264	1	0	0	0	0	1	0	0	0	5192	1722	60	5	896	5	EPHA3	3	89390133	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	27135375	89390133	108632297	27	48097											
PLA1A	51365	broad.mit.edu	37	chr3	119343977	119343977	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttggtttcctagtgcatcAcagcctcgtggagtttcact	6	15	9	11	1	2	0	2	0	0	0	4	1	3	1	2	2	2	3	2	2	1	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr3:119343977A>T	uc003ecu.2	+	9	1058	c.1019A>T	c.(1018-1020)CAC>CTC	p.H340L	PLA1A_uc003ecv.2_Missense_Mutation_p.H324L|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_Missense_Mutation_p.H167L	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	340					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CTAGTGCATCACAGCCTCGTG	0.318													19	34					0	0	0	0	T	119343977	T	T	119343977	3	4	264	1	0	0	0	0	1	0	0	0	12043	159	6	5	1053	5	PLA1A	3	119343977	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	29953844	119343977	78678453	28	48098											
MYLK	4638	broad.mit.edu	37	chr3	123512632	123512632	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcaactcttgagggatcCacactgagggaggttttgga	10	10	14	7	0	2	2	1	2	1	0	3	6	3	5	1	4	1	1	1	4	1	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr3:123512632C>T	uc003ego.2	-	4	339	c.57G>A	c.(55-57)GTG>GTA	p.V19V	MYLK_uc011bjw.1_Silent_p.V19V|MYLK_uc003egp.2_Silent_p.V19V|MYLK_uc003egq.2_Silent_p.V19V|MYLK_uc003egr.2_Silent_p.V19V|MYLK_uc003egs.2_5'UTR|MYLK_uc010hrs.1_Silent_p.V19V|MYLK_uc003egu.1_Silent_p.V29V	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	19					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TTGAGGGATCCACACTGAGGG	0.532													11	36					0	0	0	0	T	123512632	T	T	123512632	2	4	264	1	0	0	0	0	0	0	0	1	10109	581	21	4		4	MYLK	3	123512632	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	4168655	123512632	74509798	29	48099											
GMPS	8833	broad.mit.edu	37	chr3	155633846	155633847	+	Missense_Mutation	DNP	AG	TA	TA																															ggagaaatgaacttgaaaccAgaggaggttttccttgccca																										TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr3:155633846_155633847AG>TA	uc003faq.2	+	9	1412_1413	c.1077_1078AG>TA	c.(1075-1080)CCAGAG>CCTAAG	p.E360K	GMPS_uc011bom.1_Missense_Mutation_p.E261K	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	360					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	ACTTGAAACCAGAGGAGGTTTT	0.376			T	MLL	AML								9	33					0	0	0	0	TA	155633847	TA	TA	155633846	3	4	264	1	0	0	0	0	1	0	0	0	6535	175	7	5	1111	5	GMPS	3	155633846	Missense_Mutation	DNP	AG	TCGA-CV-7432-01A-11D-2129-08	32121214	155633846	42388584	30	48100											
ABCC5	10057	broad.mit.edu	37	chr3	183655818	183655818	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccagataactccaccagaCggaagagggccatccccagc	12	4	9	16	1	0	3	0	0	0	3	3	4	3	4	6	2	2	0	6	2	2	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr3:183655818C>T	uc003fmg.2	-	26	3890	c.3725G>A	c.(3724-3726)CGT>CAT	p.R1242H	ABCC5_uc011bqt.1_Missense_Mutation_p.R770H|ABCC5_uc010hxl.2_Missense_Mutation_p.R1199H	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1242	ABC transporter 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CTCCACCAGACGGAAGAGGGC	0.502													6	92					0	0	0	0	T	183655818	T	T	183655818	3	4	264	1	0	0	0	0	1	0	0	0	56	536	19	1	608	1	ABCC5	3	183655818	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	28021972	183655818	14366612	31	48101											
PCYT1A	5130	broad.mit.edu	37	chr3	195966589	195966589	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actttgtcaaccctctcctgCaagtggtatttcttctccta	7	16	5	13	0	4	0	1	0	3	0	6	0	4	0	3	1	2	2	3	1	4	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr3:195966589C>A	uc003fwg.2	-	9	899	c.726G>T	c.(724-726)TTG>TTT	p.L242F	uc003fwf.1_5'Flank|PCYT1A_uc003fwh.2_Missense_Mutation_p.L242F	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	242	Amphipathic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	CCCTCTCCTGCAAGTGGTATT	0.368													22	82					4.16121e-05	4.32126e-05	1	0	A	195966589	A	A	195966589	3	1	264	1	0	0	0	0	1	0	0	0	11664	709	25	4	385	4	PCYT1A	3	195966589	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	12310771	195966589	2055841	32	48102											
STK32B	55351	broad.mit.edu	37	chr4	5448436	5448436	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgtacatggacagaggccCcggatactcgtaccctgtcg	8	8	13	12	3	0	1	0	0	0	1	2	3	0	3	3	4	3	2	3	4	3	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr4:5448436C>T	uc003gih.1	+	7	663	c.599C>T	c.(598-600)CCC>CTC	p.P200L	STK32B_uc010ida.1_Missense_Mutation_p.P153L	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	200	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GACAGAGGCCCCGGATACTCG	0.572													24	27					0	0	0	0	T	5448436	T	T	5448436	3	4	264	1	0	0	0	0	1	0	0	0	15364	623	22	4	625	4	STK32B	4	5448436	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08		5448436	185705840	33	48103											
GBA3	57733	broad.mit.edu	37	chr4	22749519	22749519	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgaagaagagaagaaaaTgatcaaaggcactgctgatt	18	7	10	6	0	1	6	1	3	0	3	1	7	1	6	0	1	1	2	0	1	6	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr4:22749519T>C	uc003gqp.3	+	3	978	c.887T>C	c.(886-888)ATG>ACG	p.M296T	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.M297T	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	296					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						GAGAAGAAAATGATCAAAGGC	0.403													8	6					0	0	0	0	C	22749519	C	C	22749519	3	2	264	1	0	0	0	0	1	0	0	0	6303	1464	51	5	897	5	GBA3	4	22749519	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	17301083	22749519	168404757	34	48104											
ARAP2	116984	broad.mit.edu	37	chr4	36122929	36122929	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgggcattcatgtgattgaTttctgagcatttctgaaccc	9	15	9	8	0	3	4	1	4	2	0	3	4	3	4	1	1	2	2	1	1	1	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr4:36122929T>C	uc003gsq.1	-	23	4104	c.3766A>G	c.(3766-3768)ATC>GTC	p.I1256V		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1256	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						ATGTGATTGATTTCTGAGCAT	0.343													45	48					0	0	0	0	C	36122929	C	C	36122929	3	2	264	1	0	0	0	0	1	0	0	0	839	1493	52	5	1392	5	ARAP2	4	36122929	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	13373410	36122929	155031347	35	48105											
LPHN3	23284	broad.mit.edu	37	chr4	62679537	62679537	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtccacagggcaggcacaTcatggacaagtttcatacat	12	8	11	10	0	2	0	2	0	0	0	3	1	3	1	1	4	1	3	1	4	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr4:62679537T>A	uc010ihh.2	+	6	1379	c.1206T>A	c.(1204-1206)CAT>CAA	p.H402Q	LPHN3_uc003hcq.3_Missense_Mutation_p.H402Q|LPHN3_uc003hcs.1_Missense_Mutation_p.H231Q	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	402	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ggcaggcacatcatggacaag	0.114													6	53					0	0	0	0	A	62679537	A	A	62679537	3	1	264	1	0	0	0	0	1	0	0	0	8967	1432	50	5	1228	5	LPHN3	4	62679537	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	26556608	62679537	128474739	36	48106											
PDHA2	5161	broad.mit.edu	37	chr4	96762054	96762054	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattttatccctgggctaaaGgtcgatggaatggatgttct	10	14	11	6	1	1	0	0	0	1	0	3	3	2	2	1	4	0	2	1	4	5	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr4:96762054G>A	uc003htr.3	+	1	816	c.753G>A	c.(751-753)AAG>AAA	p.K251K		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	251					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CTGGGCTAAAGGTCGATGGAA	0.463													13	63					0	0	0	0	A	96762054	A	A	96762054	2	1	264	1	0	0	0	0	0	0	0	1	11719	991	35	4		4	PDHA2	4	96762054	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	34082517	96762054	94392222	37	48107											
GUCY1A3	2982	broad.mit.edu	37	chr4	156643246	156643246	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgtcgttggagttaaaatGccccgttactgtctttttgg	6	15	12	8	3	1	0	0	0	1	0	2	1	1	1	2	3	2	3	2	3	3	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr4:156643246G>A	uc003iov.2	+	10	2309	c.1773G>A	c.(1771-1773)ATG>ATA	p.M591I	GUCY1A3_uc010iqc.2_Missense_Mutation_p.M591I|GUCY1A3_uc003iow.2_Missense_Mutation_p.M591I|GUCY1A3_uc010iqd.2_Missense_Mutation_p.M590I|GUCY1A3_uc003iox.2_Missense_Mutation_p.M591I|GUCY1A3_uc003ioz.2_Missense_Mutation_p.M356I|GUCY1A3_uc003ioy.2_Missense_Mutation_p.M591I|GUCY1A3_uc010iqe.2_Missense_Mutation_p.M356I|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.M591I	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	591	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		GAGTTAAAATGCCCCGTTACT	0.423													115	129					0	0	0	0	A	156643246	A	A	156643246	3	1	264	1	0	0	0	0	1	0	0	0	6933	1319	46	4	1814	4	GUCY1A3	4	156643246	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	59881192	156643246	34511030	38	48108											
ADCY2	108	broad.mit.edu	37	chr5	7717334	7717334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggatgattcaagcaattgatGggattaatgcacagaagtga	15	10	12	4	0	1	4	1	3	0	1	1	6	1	6	0	2	2	2	0	2	4	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:7717334G>A	uc003jdz.1	+	12	1754	c.1687G>A	c.(1687-1689)GGG>AGG	p.G563R	ADCY2_uc011cmo.1_Missense_Mutation_p.G383R	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	563	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AGCAATTGATGGGATTAATGC	0.308													22	62					0	0	0	0	A	7717334	A	A	7717334	3	1	264	1	0	0	0	0	1	0	0	0	294	1348	47	4	1733	4	ADCY2	5	7717334	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08		7717334	173197926	39	48109											
CTNND2	1501	broad.mit.edu	37	chr5	11023090	11023090	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtctcgcatggcgtatttGcctggaaaagaaaataaaga	15	9	11	6	2	1	2	0	0	1	2	2	3	1	3	1	3	1	2	1	3	7	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:11023090G>T	uc003jfa.1	-	17	2935	c.2790C>A	c.(2788-2790)GGC>GGA	p.G930G	CTNND2_uc010itt.2_Silent_p.G839G|CTNND2_uc011cmy.1_Silent_p.G593G|CTNND2_uc011cmz.1_Silent_p.G497G|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.G522G	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	930					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGGCGTATTTGCCTGGAAAAG	0.507													12	35					0.00185496	0.00188108	1	0	T	11023090	T	T	11023090	2	4	264	1	0	0	0	0	0	0	0	1	4037	1333	46	4		4	CTNND2	5	11023090	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	3305756	11023090	169892170	40	48110											
FAM105A	54491	broad.mit.edu	37	chr5	14608915	14608915	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggaagtatgtgcaacacccTtttttcagatgccattctgg	10	13	9	9	0	2	1	1	0	1	1	2	2	2	2	2	2	3	2	2	2	3	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:14608915T>G	uc003jfj.2	+	7	799	c.686T>G	c.(685-687)CTT>CGT	p.L229R		NM_019018	NP_061891	Q9NUU6	F105A_HUMAN	hypothetical protein LOC54491	229										ovary(1)	1	Lung NSC(4;0.00592)					TGCAACACCCTTTTTTCAGAT	0.328													16	38					0	0	0	0	G	14608915	G	G	14608915	3	3	264	1	0	0	0	0	1	0	0	0	5415	1609	56	5	712	5	FAM105A	5	14608915	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	3585825	14608915	166306345	41	48111											
CDH6	1004	broad.mit.edu	37	chr5	31316322	31316322	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtttgtgacagataatccAaagcaaagtagtcgagtacc	14	10	10	7	1	0	2	0	1	0	1	2	3	1	2	2	1	2	4	2	1	5	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:31316322A>G	uc003jhe.1	+	9	1724	c.1398A>G	c.(1396-1398)CCA>CCG	p.P466P	CDH6_uc003jhd.1_Silent_p.P466P	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	466	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CAGATAATCCAAAGCAAAGTA	0.368													12	44					0	0	0	0	G	31316322	G	G	31316322	2	3	264	1	0	0	0	0	0	0	0	1	3129	117	5	5		5	CDH6	5	31316322	Silent	SNP	A	TCGA-CV-7432-01A-11D-2129-08	16707407	31316322	149598938	42	48112											
SLC45A2	51151	broad.mit.edu	37	chr5	33982466	33982466	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagagaacgacacctatcAtggtgacacttatggcccaa	15	7	8	11	1	1	2	1	1	0	1	1	4	1	2	2	2	1	0	2	2	5	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:33982466A>C	uc003jid.2	-	2	529	c.437T>G	c.(436-438)ATG>AGG	p.M146R	SLC45A2_uc003jie.2_Missense_Mutation_p.M146R|SLC45A2_uc003jif.3_Missense_Mutation_p.M146R|SLC45A2_uc011coe.1_Missense_Mutation_p.M146R	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	146	Helical; Name=4; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GACACCTATCATGGTGACACT	0.433													19	50					0	0	0	0	C	33982466	C	C	33982466	3	2	264	1	0	0	0	0	1	0	0	0	14705	217	8	5	1194	5	SLC45A2	5	33982466	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	2666144	33982466	146932794	43	48113											
LIFR	3977	broad.mit.edu	37	chr5	38489306	38489306	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttactaatatcgaatctgCagaagtatcctcaacagtaa	15	13	5	8	1	2	1	1	0	1	1	4	2	3	1	1	0	3	3	1	0	8	6			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:38489306C>T	uc010ive.1	-	16	2541	c.2209G>A	c.(2209-2211)GCA>ACA	p.A737T	LIFR_uc003jli.2_Missense_Mutation_p.A737T	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	737	Fibronectin type-III 6.|Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					ATCGAATCTGCAGAAGTATCC	0.358			T	PLAG1	salivary adenoma								9	48					0	0	0	0	T	38489306	T	T	38489306	3	4	264	1	0	0	0	0	1	0	0	0	8821	710	25	4	1104	4	LIFR	5	38489306	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	4506840	38489306	142425954	44	48114											
HTR1A	3350	broad.mit.edu	37	chr5	63256467	63256467	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaagagccacgatgaagaaGggcagccagcagaggatgaa	17	2	14	8	1	0	5	0	2	0	3	0	7	0	6	2	2	3	2	2	2	4	0			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:63256467G>A	uc011cqt.1	-	1	1080	c.1080C>T	c.(1078-1080)CCC>CCT	p.P360P		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	360	Helical; Name=6; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CGATGAAGAAGGGCAGCCAGC	0.597													35	132					0	0	0	0	A	63256467	A	A	63256467	2	1	264	1	0	0	0	0	0	0	0	1	7475	987	35	4		4	HTR1A	5	63256467	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	24767161	63256467	117658793	45	48115											
VCAN	1462	broad.mit.edu	37	chr5	82817564	82817564	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgaaacagaaggtagtagtAcaacaggatttacatcatct	17	10	8	6	0	2	2	1	1	1	1	2	3	2	3	0	2	4	3	0	2	7	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:82817564A>G	uc003kii.3	+	7	3795	c.3439A>G	c.(3439-3441)ACA>GCA	p.T1147A	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.T1147A|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1147	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AGGTAGTAGTACAACAGGATT	0.388													38	55					0	0	0	0	G	82817564	G	G	82817564	3	3	264	1	0	0	0	0	1	0	0	0	17206	391	14	5	3461	5	VCAN	5	82817564	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	19561097	82817564	98097696	46	48116											
C5orf36	285600	broad.mit.edu	37	chr5	93856569	93856569	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgtggcaggagaggtcccaAagtaaatccaatgtcatttc	12	10	10	9	0	1	1	1	0	0	1	4	2	3	1	2	3	0	2	2	3	4	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:93856569A>C	uc011cuk.1	-	5	611	c.354T>G	c.(352-354)CTT>CTG	p.L118L	C5orf36_uc003kkp.2_Silent_p.L118L	NM_001145678	NP_001139150	Q8IV33	K0825_HUMAN	hypothetical protein LOC285600 isoform 1	118											0		all_cancers(142;2.12e-08)|all_epithelial(76;5.95e-11)|all_lung(232;0.000996)|Lung NSC(167;0.0108)|Ovarian(174;0.0218)|Colorectal(57;0.0329)|Breast(839;0.214)|Lung SC(612;0.236)		all cancers(79;3.96e-19)		AGAGGTCCCAAAGTAAATCCA	0.358													9	28					0	0	0	0	C	93856569	C	C	93856569	2	2	264	1	0	0	0	0	0	0	0	1	2305	1	1	5		5	C5orf36	5	93856569	Silent	SNP	A	TCGA-CV-7432-01A-11D-2129-08	11039005	93856569	87058691	47	48117											
TTC37	9652	broad.mit.edu	37	chr5	94852669	94852669	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatcattcatgttgctgcctGtttctgctagatgttgtgct	5	18	10	8	0	3	1	2	0	1	1	3	2	3	1	1	0	4	6	1	0	1	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:94852669G>A	uc003klb.2	-	22	2657	c.2387C>T	c.(2386-2388)ACA>ATA	p.T796I		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	796	TPR 13.						binding			ovary(3)|pancreas(1)	4						GTTGCTGCCTGTTTCTGCTAG	0.333													7	21					0	0	0	0	A	94852669	A	A	94852669	3	1	264	1	0	0	0	0	1	0	0	0	16773	1377	48	4	2395	4	TTC37	5	94852669	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	996100	94852669	86062591	48	48118											
PCSK1	5122	broad.mit.edu	37	chr5	95746664	95746664	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgtttcccgaagcccagacGaagatggaccccttcccctg	8	7	9	17	3	0	2	0	0	0	2	2	5	2	3	7	1	1	1	7	1	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:95746664G>A	uc003kls.1	-	8	1115	c.909C>T	c.(907-909)TTC>TTT	p.F303F	PCSK1_uc010jbi.1_Intron	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	303	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAGCCCAGACGAAGATGGACC	0.498													14	145					0	0	0	0	A	95746664	A	A	95746664	2	1	264	1	0	0	0	0	0	0	0	1	11654	1049	37	1		1	PCSK1	5	95746664	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	893995	95746664	85168596	49	48119											
FBN2	2201	broad.mit.edu	37	chr5	127638678	127638678	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacttacccaggcaatcattAttatgagtgagttcaaaccc	13	12	6	10	0	2	2	2	2	0	0	2	2	2	2	2	1	3	2	2	1	6	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:127638678A>C	uc003kuu.2	-	46	6343	c.5904T>G	c.(5902-5904)AAT>AAG	p.N1968K		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1968	EGF-like 32; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGCAATCATTATTATGAGTGA	0.373													41	91					0	0	0	0	C	127638678	C	C	127638678	3	2	264	1	0	0	0	0	1	0	0	0	5735	446	16	5	2914	5	FBN2	5	127638678	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	31892014	127638678	53276582	50	48120											
RAPGEF6	51735	broad.mit.edu	37	chr5	130883877	130883878	+	Frame_Shift_Ins	INS	-	C	C																															tcttcattatctttggcattINSctctacctgaaacacatgtt																										TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:130883877_130883878insC	uc003kvn.1	-	6	563_564	c.357_358insG	c.(355-360)GAGAATfs	p.E119fs	RAPGEF6_uc003kvp.1_Frame_Shift_Ins_p.E169fs|RAPGEF6_uc003kvo.1_Frame_Shift_Ins_p.E119fs|RAPGEF6_uc010jdi.1_Frame_Shift_Ins_p.E119fs|RAPGEF6_uc010jdj.1_Frame_Shift_Ins_p.E119fs|RAPGEF6_uc003kvr.2_Frame_Shift_Ins_p.E119fs|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Frame_Shift_Ins_p.E119fs	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	119_120					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TCTTTGGCATTCTCTACCTGAA	0.342													---	---	---								C	130883878	C	C	130883877	7	5	264	1	0	1	1	0	0	0	0	0	13113	1783	62	0	5025	0	RAPGEF6	5	130883877	Frame_Shift_Ins	INS	-	TCGA-CV-7432-01A-11D-2129-08	3245199	130883877	50031383	51	48121											
PCDHA13	56136	broad.mit.edu	37	chr5	140261865	140261865	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtgtaccatgctgtcttcCtggcaaggaggcccaagacc	9	8	12	12	0	1	1	0	0	1	1	2	3	2	2	4	3	2	3	4	3	3	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:140261865C>T	uc003lif.2	+	1	12	c.12C>T	c.(10-12)TCC>TCT	p.S4S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.S4S|PCDHA13_uc003lid.2_Silent_p.S4S	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	4					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTGTCTTCCTGGCAAGGAG	0.542													49	151					0	0	0	0	T	140261865	T	T	140261865	2	4	264	1	0	0	0	0	0	0	0	1	11577	668	24	4		4	PCDHA13	5	140261865	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	9377988	140261865	40653395	52	48122											
PCDHA13	56136	broad.mit.edu	37	chr5	140262129	140262129	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaattctcggatcgaccgCgaggagctgtgtgggcggag	7	8	18	8	5	1	1	0	1	1	0	3	6	1	4	1	4	1	1	1	4	1	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:140262129C>T	uc003lif.2	+	1	276	c.276C>T	c.(274-276)CGC>CGT	p.R92R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.R92R|PCDHA13_uc003lid.2_Silent_p.R92R	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATCGACCGCGAGGAGCTGT	0.587													17	284					0	0	0	0	T	140262129	T	T	140262129	2	4	264	1	0	0	0	0	0	0	0	1	11577	755	27	1		1	PCDHA13	5	140262129	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	264	140262129	40653131	53	48123											
PCDHB3	56132	broad.mit.edu	37	chr5	140480873	140480873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactcagcttaacgctcaccGcgctggacggcggctctccc	7	7	10	17	5	3	0	2	0	1	0	4	1	3	1	2	3	3	4	2	3	2	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:140480873G>A	uc003lio.2	+	1	640	c.640G>A	c.(640-642)GCG>ACG	p.A214T	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	214	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACGCTCACCGCGCTGGACGG	0.562													18	51					0	0	0	0	A	140480873	A	A	140480873	3	1	264	1	0	0	0	0	1	0	0	0	11597	1087	38	1	642	1	PCDHB3	5	140480873	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	218744	140480873	40434387	54	48124											
PCDHB14	56122	broad.mit.edu	37	chr5	140605137	140605137	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcccaggccgactccctcaCcgtctacctggtggtggcat	5	8	12	16	2	2	0	1	0	1	0	3	1	3	0	5	5	1	1	5	5	1	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:140605137C>T	uc003ljb.2	+	1	2060	c.2060C>T	c.(2059-2061)ACC>ATC	p.T687I	PCDHB14_uc011dal.1_Missense_Mutation_p.T534I	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	687	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACTCCCTCACCGTCTACCTG	0.711													75	115					0	0	0	0	T	140605137	T	T	140605137	3	4	264	1	0	0	0	0	1	0	0	0	11593	507	18	4	2062	4	PCDHB14	5	140605137	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	124264	140605137	40310123	55	48125											
CDX1	1044	broad.mit.edu	37	chr5	149562461	149562461	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gagctggctgccaatctgggGctcactgaacggcaggtgtg	7	8	16	10	1	2	1	1	1	1	0	2	2	2	1	1	5	3	4	1	5	2	0			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:149562461G>A	uc003lrq.2	+	2	672	c.576G>A	c.(574-576)GGG>GGA	p.G192G		NM_001804	NP_001795	P47902	CDX1_HUMAN	caudal type homeobox 1	192	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAATCTGGGGCTCACTGAAC	0.562													40	81					0	0	0	0	A	149562461	A	A	149562461	2	1	264	1	0	0	0	0	0	0	0	1	3197	1190	42	4		4	CDX1	5	149562461	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	8957324	149562461	31352799	56	48126											
GRIA1	2890	broad.mit.edu	37	chr5	153175081	153175081	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaactcagtgagcaaggcgtCttagacaagctgaaaagcaa	17	6	10	8	1	2	3	1	2	1	1	2	3	2	3	0	1	4	3	0	1	7	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:153175081C>G	uc003lva.3	+	14	2681	c.2316C>G	c.(2314-2316)GTC>GTG	p.V772V	GRIA1_uc003luy.3_Intron|GRIA1_uc003luz.3_Silent_p.V677V|GRIA1_uc011dcv.1_Intron|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Intron|GRIA1_uc011dcy.1_Silent_p.V782V|GRIA1_uc011dcz.1_Intron	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	772	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGCAAGGCGTCTTAGACAAGC	0.448													15	29					0	0	0	0	G	153175081	G	G	153175081	2	3	264	1	0	0	0	0	0	0	0	1	6806	900	32	2		2	GRIA1	5	153175081	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	3612620	153175081	27740179	57	48127											
CYFIP2	26999	broad.mit.edu	37	chr5	156721850	156721850	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgtacacctggcgcagctGttcccgggccattcccaggt	5	9	12	15	2	0	0	0	0	0	0	2	0	2	0	4	3	2	5	4	3	1	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:156721850G>C	uc003lwq.2	+	4	404	c.266G>C	c.(265-267)TGT>TCT	p.C89S	CYFIP2_uc011ddn.1_Intron|CYFIP2_uc011ddo.1_Intron|CYFIP2_uc003lwr.2_Missense_Mutation_p.C89S|CYFIP2_uc003lws.2_Missense_Mutation_p.C89S|CYFIP2_uc003lwt.2_5'Flank|CYFIP2_uc011ddp.1_5'Flank|CYFIP2_uc003lwp.2_5'UTR	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	89					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGCGCAGCTGTTCCCGGGCC	0.537													11	18					0	0	0	0	C	156721850	C	C	156721850	3	2	264	1	0	0	0	0	1	0	0	0	4155	1377	48	4	276	4	CYFIP2	5	156721850	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	3546769	156721850	24193410	58	48128											
CYFIP2	26999	broad.mit.edu	37	chr5	156738742	156738742	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatggttcagatccgggatGaccacatccgcttcatctcc	9	10	9	13	2	3	3	2	1	1	2	6	4	5	4	4	2	0	2	4	2	0	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:156738742G>T	uc003lwq.2	+	13	1201	c.1063G>T	c.(1063-1065)GAC>TAC	p.D355Y	CYFIP2_uc011ddn.1_Missense_Mutation_p.D329Y|CYFIP2_uc011ddo.1_Missense_Mutation_p.D159Y|CYFIP2_uc003lwr.2_Missense_Mutation_p.D355Y|CYFIP2_uc003lws.2_Missense_Mutation_p.D355Y|CYFIP2_uc003lwt.2_Missense_Mutation_p.D233Y|CYFIP2_uc011ddp.1_Missense_Mutation_p.D89Y	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	355					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GATCCGGGATGACCACATCCG	0.612													5	10					5.9392e-07	6.44657e-07	1	0	T	156738742	T	T	156738742	3	4	264	1	0	0	0	0	1	0	0	0	4155	1290	45	2	1101	2	CYFIP2	5	156738742	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	16892	156738742	24176518	59	48129											
SLIT3	6586	broad.mit.edu	37	chr5	168123340	168123340	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacgtagttgttgatcccGtccacgcaggtggcattgtt	7	12	11	11	3	0	1	0	1	0	0	2	1	2	1	2	2	0	6	2	2	1	5	rs79266600	by1000genomes	TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:168123340G>A	uc003mab.2	-	28	3459	c.3039C>T	c.(3037-3039)GAC>GAT	p.D1013D	SLIT3_uc010jjg.2_Silent_p.D1020D	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1013	EGF-like 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTTGATCCCGTCCACGCAGG	0.532													24	78					0	0	0	0	A	168123340	A	A	168123340	2	1	264	1	0	0	0	0	0	0	0	1	14805	1136	40	1		1	SLIT3	5	168123340	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	11384598	168123340	12791920	60	48130											
DOCK2	1794	broad.mit.edu	37	chr5	169461497	169461497	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctggagaagctgctggatTaccggggtgtgatgacagat	9	10	15	7	1	0	4	0	2	0	2	1	6	1	5	2	4	3	2	2	4	2	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:169461497T>A	uc003maf.2	+	35	3642	c.3562T>A	c.(3562-3564)TAC>AAC	p.Y1188N	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.Y680N	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1188	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTGCTGGATTACCGGGGTGT	0.587													7	59					0	0	0	0	A	169461497	A	A	169461497	3	1	264	1	0	0	0	0	1	0	0	0	4709	1754	61	5	3700	5	DOCK2	5	169461497	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	1338157	169461497	11453763	61	48131											
FAF2	23197	broad.mit.edu	37	chr5	175913486	175913486	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgtctcaagacctcaacCaagggcaagttatttcatag	12	12	8	9	0	3	1	3	0	1	1	4	1	3	1	2	1	1	3	2	1	6	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr5:175913486C>T	uc003mej.3	+	3	316	c.263C>T	c.(262-264)CCA>CTA	p.P88L		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	88					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						AGACCTCAACCAAGGGCAAGT	0.433													16	62					0	0	0	0	T	175913486	T	T	175913486	3	4	264	1	0	0	0	0	1	0	0	0	5398	594	21	4	273	4	FAF2	5	175913486	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	6451989	175913486	5001774	62	48132											
SCGN	10590	broad.mit.edu	37	chr6	25689756	25689756	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatctttgcctactatgAtgttgtaagtgtgcgtcttt	9	17	9	6	1	2	1	0	1	2	0	2	2	2	1	1	0	3	2	1	0	5	6	rs143515197		TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:25689756A>T	uc003nfb.2	+	9	832	c.629A>T	c.(628-630)GAT>GTT	p.D210V	SCGN_uc010jpz.2_Missense_Mutation_p.D101V	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	210	EF-hand 5.|5 (Potential).					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						GCCTACTATGATGTTGTAAGT	0.398													38	88					0	0	0	0	T	25689756	T	T	25689756	3	4	264	1	0	0	0	0	1	0	0	0	13968	333	12	5	663	5	SCGN	6	25689756	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08		25689756	145425311	63	48133											
PI16	221476	broad.mit.edu	37	chr6	36930839	36930839	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttccctagcaacggggattCcggctttcttggtaacagag	8	11	11	11	2	1	1	0	0	1	1	3	2	3	2	2	4	3	3	2	4	3	6			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:36930839C>T	uc003ona.2	+	5	1049	c.721C>T	c.(721-723)CCG>TCG	p.P241S	PI16_uc003omz.1_Intron|PI16_uc003onb.2_Intron|PI16_uc011dts.1_Missense_Mutation_p.P12S	NM_153370	NP_699201	Q6UXB8	PI16_HUMAN	protease inhibitor 16 precursor	241	Extracellular (Potential).					extracellular region|integral to membrane	peptidase inhibitor activity				0						AACGGGGATTCCGGCTTTCTT	0.562													42	90					0	0	0	0	T	36930839	T	T	36930839	3	4	264	1	0	0	0	0	1	0	0	0	11924	855	30	2	739	2	PI16	6	36930839	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	11241083	36930839	134184228	64	48134											
PGK2	5232	broad.mit.edu	37	chr6	49753700	49753700	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattttaccttccagaagctCtagactggcaccgcctccag	9	10	8	14	1	1	2	0	0	1	2	3	3	3	2	5	1	2	2	5	1	3	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:49753700C>A	uc003ozu.2	-	1	1308	c.1201G>T	c.(1201-1203)GAG>TAG	p.E401*		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	401					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					TCCAGAAGCTCTAGACTGGCA	0.473													33	86					1.06801e-11	1.21416e-11	1	0	A	49753700	A	A	49753700	4	1	264	1	0	0	0	0	0	1	0	0	11846	922	32	2	56	2	PGK2	6	49753700	Nonsense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	12822861	49753700	121361367	65	48135											
LRRC1	55227	broad.mit.edu	37	chr6	53787549	53787549	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggactggactcaaacaaaaaCgaggtcaatcatgccattga	16	7	9	9	1	3	1	3	1	0	0	3	4	3	3	1	3	3	0	1	3	4	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:53787549C>T	uc003pcd.1	+	14	1810	c.1533C>T	c.(1531-1533)AAC>AAT	p.N511N		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	511	Potential.					cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		CAAACAAAAACGAGGTCAATC	0.473													41	233					0	0	0	0	T	53787549	T	T	53787549	2	4	264	1	0	0	0	0	0	0	0	1	9016	535	19	1		1	LRRC1	6	53787549	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	4033849	53787549	117327518	66	48136											
DOPEY1	23033	broad.mit.edu	37	chr6	83820000	83820000	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagctttctatggaagatcaActttatataattggcagtga	14	14	8	5	0	2	2	1	1	1	1	2	3	2	3	0	2	2	2	0	2	7	7			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:83820000A>T	uc003pjs.1	+	6	908	c.648A>T	c.(646-648)CAA>CAT	p.Q216H	DOPEY1_uc011dyy.1_Missense_Mutation_p.Q216H|DOPEY1_uc010kbl.1_Missense_Mutation_p.Q216H	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	216					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TGGAAGATCAACTTTATATAA	0.328													80	152					0	0	0	0	T	83820000	T	T	83820000	3	4	264	1	0	0	0	0	1	0	0	0	4729	40	2	5	662	5	DOPEY1	6	83820000	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	30032451	83820000	87295067	67	48137											
GJA10	84694	broad.mit.edu	37	chr6	90604421	90604421	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atctctttgatcaggttctgGgttttacagatcatctttgt	7	19	8	7	0	5	2	2	1	3	1	6	2	5	2	0	2	1	2	0	2	1	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:90604421G>A	uc011eaa.1	+	1	234	c.234G>A	c.(232-234)TGG>TGA	p.W78*		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	78	Helical; (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TCAGGTTCTGGGTTTTACAGA	0.453													15	54					0	0	0	0	A	90604421	A	A	90604421	4	1	264	1	0	0	0	0	0	1	0	0	6438	1241	43	4	236	4	GJA10	6	90604421	Nonsense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	6784421	90604421	80510646	68	48138											
KIAA1919	91749	broad.mit.edu	37	chr6	111587184	111587184	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctttttggctccactgctagCtaaactggctttgggtccga	6	14	10	11	1	0	0	0	0	0	0	2	1	2	0	2	3	3	4	2	3	3	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:111587184C>A	uc003puv.3	+	4	841	c.419C>A	c.(418-420)GCT>GAT	p.A140D		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	140	Helical; (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		CCACTGCTAGCTAAACTGGCT	0.507													5	47					1.23904e-05	1.29291e-05	1	0	A	111587184	A	A	111587184	3	1	264	1	0	0	0	0	1	0	0	0	8301	797	28	4	433	4	KIAA1919	6	111587184	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	20982763	111587184	59527883	69	48139											
REV3L	5980	broad.mit.edu	37	chr6	111695451	111695451	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagatatctgtgtattctgTgctacctgagataaatgatt	12	15	9	5	0	2	3	0	2	2	2	2	5	2	3	1	0	2	2	1	0	6	6			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:111695451T>C	uc003puy.3	-	13	4430	c.4107A>G	c.(4105-4107)GCA>GCG	p.A1369A	REV3L_uc003pux.3_Silent_p.A1291A|REV3L_uc003puz.3_Silent_p.A1291A	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1369					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GTGTATTCTGTGCTACCTGAG	0.303								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					38	68					0	0	0	0	C	111695451	C	C	111695451	2	2	264	1	0	0	0	0	0	0	0	1	13305	1683	59	5		5	REV3L	6	111695451	Silent	SNP	T	TCGA-CV-7432-01A-11D-2129-08	108267	111695451	59419616	70	48140											
NMBR	4829	broad.mit.edu	37	chr6	142399733	142399733	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtattctccaggaagattgtGtgcgcttttaattaaggtct	9	16	10	6	1	2	1	0	0	2	1	3	2	2	2	1	2	1	2	1	2	4	6			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:142399733G>T	uc003qiu.2	-	2	871	c.730C>A	c.(730-732)CAC>AAC	p.H244N		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	244	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		GGAAGATTGTGTGCGCTTTTA	0.358													17	39					3.52763e-06	3.75354e-06	1	0	T	142399733	T	T	142399733	3	4	264	1	0	0	0	0	1	0	0	0	10541	1377	48	4	450	4	NMBR	6	142399733	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	30704282	142399733	28715334	71	48141											
UTRN	7402	broad.mit.edu	37	chr6	144844227	144844227	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagccagatgtcatccttGaagcctctggacctgaagcc	11	8	9	13	0	2	3	1	2	1	1	3	4	3	4	5	1	4	0	5	1	3	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:144844227G>T	uc003qkt.2	+	40	5901	c.5809G>T	c.(5809-5811)GAA>TAA	p.E1937*		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1937	Spectrin 13.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TGTCATCCTTGAAGCCTCTGG	0.383													19	56					2.5808e-16	3.04619e-16	1	0	T	144844227	T	T	144844227	4	4	264	1	0	0	0	0	0	1	0	0	17171	1291	45	2	5967	2	UTRN	6	144844227	Nonsense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	2444494	144844227	26270840	72	48142											
SYNE1	23345	broad.mit.edu	37	chr6	152786398	152786398	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaaccaatcttaccttttTggcattttctgattgattga	10	18	6	7	0	2	4	0	4	2	0	2	4	2	4	2	1	2	1	2	1	3	7	rs34859110		TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr6:152786398T>A	uc010kiw.2	-	18	2529	c.1927A>T	c.(1927-1929)AAA>TAA	p.K643*	SYNE1_uc003qot.3_Nonsense_Mutation_p.K650*|SYNE1_uc003qou.3_Nonsense_Mutation_p.K643*|SYNE1_uc010kjb.1_Nonsense_Mutation_p.K626*|SYNE1_uc003qpa.1_Nonsense_Mutation_p.K643*|SYNE1_uc003qow.2_5'Flank|SYNE1_uc003qox.1_Nonsense_Mutation_p.K159*|SYNE1_uc003qoz.2_Nonsense_Mutation_p.K75*|SYNE1_uc003qoy.2_Nonsense_Mutation_p.K210*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	643	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTACCTTTTTGGCATTTTCT	0.403										HNSCC(10;0.0054)			34	84					0	0	0	0	A	152786398	A	A	152786398	4	1	264	1	0	0	0	0	0	1	0	0	15511	1821	63	5	25055	5	SYNE1	6	152786398	Nonsense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	7942171	152786398	18328669	73	48143											
DAGLB	221955	broad.mit.edu	37	chr7	6452471	6452471	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgcagtgcgcgaccactcGcaagattcttctcttcagat	9	12	8	12	3	3	2	1	0	2	2	5	3	3	2	1	0	2	2	1	0	1	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr7:6452471G>A	uc003sqa.2	-	13	1710	c.1540C>T	c.(1540-1542)CGA>TGA	p.R514*	DAGLB_uc003spy.2_Nonsense_Mutation_p.R60*|DAGLB_uc003spz.2_Nonsense_Mutation_p.R211*|DAGLB_uc011jwt.1_Nonsense_Mutation_p.R328*|DAGLB_uc011jwu.1_Nonsense_Mutation_p.R385*|DAGLB_uc003sqb.2_Nonsense_Mutation_p.R233*|DAGLB_uc003sqc.2_Nonsense_Mutation_p.R233*|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Nonsense_Mutation_p.R473*	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	514	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		GCGACCACTCGCAAGATTCTT	0.592													3	14					0	0	0	0	A	6452471	A	A	6452471	4	1	264	1	0	0	0	0	0	1	0	0	4244	1095	38	1	490	1	DAGLB	7	6452471	Nonsense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08		6452471	152686192	74	48144											
THSD7A	221981	broad.mit.edu	37	chr7	11676534	11676534	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catgagcacaccacacagccCtcgtttggatgcctccggga	9	7	10	15	2	0	1	0	1	0	0	2	3	1	3	4	2	3	2	4	2	0	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr7:11676534C>A	uc003ssf.3	-	2	497	c.245G>T	c.(244-246)AGG>ATG	p.R82M		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	82	TSP type-1 1.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCACACAGCCCTCGTTTGGAT	0.463										HNSCC(18;0.044)			30	81					2.28855e-06	2.44716e-06	1	0	A	11676534	A	A	11676534	3	1	264	1	0	0	0	0	1	0	0	0	15945	681	24	4	4832	4	THSD7A	7	11676534	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	5224063	11676534	147462129	75	48145											
TMEM195	392636	broad.mit.edu	37	chr7	15470671	15470671	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagactgtctcagtgctgTggataagttatagtcttcag	10	13	11	7	0	3	1	2	0	2	1	4	3	3	2	0	1	1	2	0	1	3	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr7:15470671T>A	uc003stb.1	-	4	642	c.472A>T	c.(472-474)ACA>TCA	p.T158S		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	158					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						CTCAGTGCTGTGGATAAGTTA	0.358													38	84					0	0	0	0	A	15470671	A	A	15470671	3	1	264	1	0	0	0	0	1	0	0	0	16183	1696	59	5	905	5	TMEM195	7	15470671	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	3794137	15470671	143667992	76	48146											
MPP6	51678	broad.mit.edu	37	chr7	24708126	24708126	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttcatttagaatttgatCgtcatgaaatccagatatat	13	18	5	5	1	2	4	2	2	0	2	4	4	3	4	1	0	0	0	1	0	5	7			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr7:24708126C>A	uc003swx.2	+	10	1260	c.961C>A	c.(961-963)CGT>AGT	p.R321S	MPP6_uc003swy.2_Missense_Mutation_p.R321S|MPP6_uc010kur.2_5'UTR	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	321					protein complex assembly		protein binding				0						AGAATTTGATCGTCATGAAAT	0.368													13	23					9.31168e-06	9.7637e-06	1	0	A	24708126	A	A	24708126	3	1	264	1	0	0	0	0	1	0	0	0	9791	884	31	3	991	3	MPP6	7	24708126	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	9237455	24708126	134430537	77	48147											
COBL	23242	broad.mit.edu	37	chr7	51287530	51287530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgcctccttcatgcgaacCaagttctgctgcgacccgag	8	8	10	15	4	2	0	1	0	1	0	3	3	3	0	4	0	5	2	4	0	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr7:51287530C>G	uc003tpr.3	-	2	338	c.153G>C	c.(151-153)TTG>TTC	p.L51F	COBL_uc003tps.2_Missense_Mutation_p.L51F|COBL_uc011kcl.1_Missense_Mutation_p.L51F|COBL_uc010kzc.2_Missense_Mutation_p.L51F|COBL_uc003tpt.2_Missense_Mutation_p.L51F	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	51										skin(3)|ovary(2)	5	Glioma(55;0.08)					TCATGCGAACCAAGTTCTGCT	0.642													5	72					0	0	0	0	G	51287530	G	G	51287530	3	3	264	1	0	0	0	0	1	0	0	0	3668	593	21	4	3680	4	COBL	7	51287530	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	26579404	51287530	107851133	78	48148											
ABCB1	5243	broad.mit.edu	37	chr7	87135328	87135328	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctggccaccagagagctgaGttcctttgtctcctacttta	7	14	8	12	0	2	2	0	1	2	1	4	3	3	2	4	1	2	2	4	1	2	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr7:87135328G>A	uc003uiz.1	-	28	3939	c.3521C>T	c.(3520-3522)ACT>ATT	p.T1174I	ABCB1_uc011khc.1_Missense_Mutation_p.T1110I	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	1174	Cytoplasmic (Potential).|ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AGAGAGCTGAGTTCCTTTGTC	0.403													32	55					0	0	0	0	A	87135328	A	A	87135328	3	1	264	1	0	0	0	0	1	0	0	0	40	1029	36	4	329	4	ABCB1	7	87135328	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	35847798	87135328	72003335	79	48149											
DYNC1I1	1780	broad.mit.edu	37	chr7	95439771	95439771	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatcgcaaacgacgagagaCagaggctttgctgcaaagca	14	5	13	9	3	0	2	0	0	0	2	1	6	0	3	0	2	4	5	0	2	2	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr7:95439771C>G	uc003uoc.3	+	3	453	c.176C>G	c.(175-177)ACA>AGA	p.T59R	DYNC1I1_uc003uod.3_Missense_Mutation_p.T59R|DYNC1I1_uc003uob.2_Missense_Mutation_p.T59R|DYNC1I1_uc003uoe.3_Missense_Mutation_p.T59R|DYNC1I1_uc010lfl.2_Missense_Mutation_p.T65R	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	59	Interaction with DCTN1 (By similarity).				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CGACGAGAGACAGAGGCTTTG	0.453													5	35					0	0	0	0	G	95439771	G	G	95439771	3	3	264	1	0	0	0	0	1	0	0	0	4864	478	17	4	182	4	DYNC1I1	7	95439771	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	8304443	95439771	63698892	80	48150											
CFTR	1080	broad.mit.edu	37	chr7	117235095	117235095	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtgctaatttggtgcttaGtaatttttctggcagaggta	8	18	11	4	0	1	1	0	0	1	1	1	1	1	1	0	3	2	5	0	3	4	8			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr7:117235095G>A	uc003vjd.2	+	15	2734	c.2602G>A	c.(2602-2604)GTA>ATA	p.V868I	CFTR_uc011knq.1_Missense_Mutation_p.V274I	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	868	Helical; Name=7; (Potential).|ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TTGGTGCTTAGTAATTTTTCT	0.303									Cystic_Fibrosis				17	36					0	0	0	0	A	117235095	A	A	117235095	3	1	264	1	0	0	0	0	1	0	0	0	3309	1029	36	4	2660	4	CFTR	7	117235095	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	21795324	117235095	41903568	81	48151											
CHRM2	1129	broad.mit.edu	37	chr7	136700564	136700564	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctgggccattccaaagatGagaactctaagcaaacatgc	14	7	8	12	0	1	2	0	1	1	2	2	3	2	2	3	1	4	1	3	1	4	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr7:136700564G>A	uc003vtf.1	+	4	1575	c.952G>A	c.(952-954)GAG>AAG	p.E318K	CHRM2_uc003vtg.1_Missense_Mutation_p.E318K|CHRM2_uc003vtj.1_Missense_Mutation_p.E318K|CHRM2_uc003vtk.1_Missense_Mutation_p.E318K|CHRM2_uc003vtl.1_Missense_Mutation_p.E318K|CHRM2_uc003vtm.1_Missense_Mutation_p.E318K|CHRM2_uc003vti.1_Missense_Mutation_p.E318K|CHRM2_uc003vto.1_Missense_Mutation_p.E318K|CHRM2_uc003vtn.1_Missense_Mutation_p.E318K|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	318	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	TTCCAAAGATGAGAACTCTAA	0.468													33	74					0	0	0	0	A	136700564	A	A	136700564	3	1	264	1	0	0	0	0	1	0	0	0	3392	1291	45	2	954	2	CHRM2	7	136700564	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	19465469	136700564	22438099	82	48152											
SSPO	23145	broad.mit.edu	37	chr7	149493814	149493814	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatgaggagggctgtgtgttGctgcctgagggcactggcag	6	9	19	7	0	0	2	0	2	0	0	0	4	0	3	1	4	2	5	1	4	0	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr7:149493814G>A	uc010lpk.2	+	46	6810	c.6810G>A	c.(6808-6810)TTG>TTA	p.L2270L		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2270					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCTGTGTGTTGCTGCCTGAGG	0.652													4	10					0	0	0	0	A	149493814	A	A	149493814	2	1	264	1	0	0	0	0	0	0	0	1	15255	1310	46	4		4	SSPO	7	149493814	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	12793250	149493814	9644849	83	48153											
MYOM2	9172	broad.mit.edu	37	chr8	2024315	2024315	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatcgtgacctggaagccGcccaacaccaccactgagag	11	5	10	15	2	1	2	1	2	0	1	2	4	1	3	5	1	2	0	5	1	2	0			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr8:2024315G>A	uc003wpx.3	+	11	1353	c.1215G>A	c.(1213-1215)CCG>CCA	p.P405P	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	405	Fibronectin type-III 1.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CCTGGAAGCCGCCCAACACCA	0.622													10	18					0	0	0	0	A	2024315	A	A	2024315	2	1	264	1	0	0	0	0	0	0	0	1	10145	1074	38	1		1	MYOM2	8	2024315	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08		2024315	144339707	84	48154											
CSMD1	64478	broad.mit.edu	37	chr8	2820134	2820134	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cactaagtcgcccttctgcgGggatgccagggtctccgcag	6	8	13	14	3	2	0	0	0	2	0	4	1	2	1	3	3	2	1	3	3	1	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr8:2820134G>A	uc011kwk.1	-	61	9875	c.9485C>T	c.(9484-9486)CCC>CTC	p.P3162L	CSMD1_uc011kwj.1_Missense_Mutation_p.P2491L|CSMD1_uc010lrg.2_Missense_Mutation_p.P1053L	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3162	Extracellular (Potential).|Sushi 26.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCTTCTGCGGGGATGCCAGG	0.493													9	28					0	0	0	0	A	2820134	A	A	2820134	3	1	264	1	0	0	0	0	1	0	0	0	3961	1232	43	4	1252	4	CSMD1	8	2820134	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	795819	2820134	143543888	85	48155											
NECAB1	64168	broad.mit.edu	37	chr8	91929769	91929769	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcgtaactagatttttatTgaaggaaaccctgaatcagc	14	13	7	7	1	1	3	1	2	0	1	2	4	1	4	1	1	3	1	1	1	6	7			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr8:91929769T>A	uc011lgg.1	+	6	601	c.407T>A	c.(406-408)TTG>TAG	p.L136*		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	136	Potential.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			AGATTTTTATTGAAGGAAACC	0.403													15	31					0	0	0	0	A	91929769	A	A	91929769	4	1	264	1	0	0	0	0	0	1	0	0	10358	1821	63	5	429	5	NECAB1	8	91929769	Nonsense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	89109635	91929769	54434253	86	48156											
TSPYL5	85453	broad.mit.edu	37	chr8	98290055	98290055	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgcgggaggactttcgaccCcgacttcggccgctcatggt	5	8	14	14	6	1	0	1	0	0	0	3	4	1	2	3	4	0	1	3	4	0	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr8:98290055C>A	uc003yhy.2	-	1	122	c.18G>T	c.(16-18)CGG>CGT	p.R6R		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	6					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					ACTTTCGACCCCGACTTCGGC	0.706													7	6					3.09899e-07	3.39787e-07	1	0	A	98290055	A	A	98290055	2	1	264	1	0	0	0	0	0	0	0	1	16729	610	22	4		4	TSPYL5	8	98290055	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	6360286	98290055	48073967	87	48157											
ABRA	137735	broad.mit.edu	37	chr8	107782189	107782189	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtggcgactttggggcaCtctgagctttctggtgtgaa	5	12	17	7	1	2	2	0	2	2	0	2	3	2	2	0	6	1	2	0	6	1	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr8:107782189C>A	uc003ymm.3	-	1	284	c.230G>T	c.(229-231)AGT>ATT	p.S77I		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	77					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CTTTGGGGCACTCTGAGCTTT	0.572													31	89					3.11337e-16	3.65483e-16	1	0	A	107782189	A	A	107782189	3	1	264	1	0	0	0	0	1	0	0	0	100	565	20	4	923	4	ABRA	8	107782189	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	9492134	107782189	38581833	88	48158											
PTK2	5747	broad.mit.edu	37	chr8	141900746	141900746	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taatactcgctccattgcacCaggagaacgttccataccag	12	9	7	13	2	0	1	0	0	0	1	3	2	2	1	4	1	4	3	4	1	4	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr8:141900746C>A	uc003yvu.2	-	3	321	c.91G>T	c.(91-93)GGT>TGT	p.G31C	PTK2_uc003yvs.2_Missense_Mutation_p.G31C|PTK2_uc003yvt.2_Missense_Mutation_p.G53C|PTK2_uc003yvv.2_5'UTR|PTK2_uc011ljr.1_Missense_Mutation_p.G31C	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	31					axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TCCATTGCACCAGGAGAACGT	0.443													27	76					1.1804e-14	1.36345e-14	1	0	A	141900746	A	A	141900746	3	1	264	1	0	0	0	0	1	0	0	0	12825	594	21	4	3187	4	PTK2	8	141900746	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	34118557	141900746	4463276	89	48159											
ZNF623	9831	broad.mit.edu	37	chr8	144732254	144732254	+	Frame_Shift_Del	DEL	C	-	-																															aggtcagagcctggggagttCcccctctcaggacaggggct																										TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr8:144732254delC	uc003yzd.2	+	1	301	c.212delC	c.(211-213)TCCfs	p.S71fs	ZNF623_uc011lkp.1_Frame_Shift_Del_p.S31fs|ZNF623_uc003yzc.2_Frame_Shift_Del_p.S31fs	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	71					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTGGGGAGTTCCCCCTCTCAG	0.572													---	---	---								-	144732254	-	-	144732254	7	5	264	1	0	1	0	1	0	0	0	0	18114	855	30	0	214	0	ZNF623	8	144732254	Frame_Shift_Del	DEL	C	TCGA-CV-7432-01A-11D-2129-08	2831508	144732254	1631768	90	48160											
PLEC	5339	broad.mit.edu	37	chr8	144990748	144990748	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgggcgtccaccgtgccgCgctgcagggcctcgtccagg	3	6	16	16	6	0	0	0	0	0	0	3	0	2	0	5	3	3	2	5	3	0	0			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr8:144990748C>T	uc003zaf.1	-	32	13822	c.13652G>A	c.(13651-13653)CGC>CAC	p.R4551H	PLEC_uc003zab.1_Missense_Mutation_p.R4414H|PLEC_uc003zac.1_Missense_Mutation_p.R4418H|PLEC_uc003zad.2_Missense_Mutation_p.R4414H|PLEC_uc003zae.1_Missense_Mutation_p.R4382H|PLEC_uc003zag.1_Missense_Mutation_p.R4392H|PLEC_uc003zah.2_Missense_Mutation_p.R4400H|PLEC_uc003zaj.2_Missense_Mutation_p.R4441H	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4551	Plectin 32.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CACCGTGCCGCGCTGCAGGGC	0.672													7	75					0	0	0	0	T	144990748	T	T	144990748	3	4	264	1	0	0	0	0	1	0	0	0	12107	768	27	1	406	1	PLEC	8	144990748	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	258494	144990748	1373274	91	48161											
CDKN2A	1029	broad.mit.edu	37	chr9	21971196	21971198	+	In_Frame_Del	DEL	CAT	-	-																															tccgccactcgggcgctgccCatcatcatgacctgccagag																										TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr9:21971196_21971198delCAT	uc003zpk.2	-	2	372_374	c.160_162delATG	c.(160-162)ATGdel	p.M54del	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_In_Frame_Del_p.D109del	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	54	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(14)|p.M53_R58del(3)|p.M54fs*92(2)|p.M54fs*61(2)|p.M54fs*66(2)|p.V28_V51del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GGGCGCTGCCCATCATCATGACC	0.68		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---								-	21971198	-	-	21971196	7	5	264	1	0	1	0	1	0	0	0	0	3176	594	21	0	316	0	CDKN2A	9	21971196	In_Frame_Del	DEL	CAT	TCGA-CV-7432-01A-11D-2129-08		21971196	119242235	92	48162											
ALDH1A1	216	broad.mit.edu	37	chr9	75531989	75531989	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggccctggtggtagaatacCccatggtgtgcaaattcaac	10	10	11	10	0	1	1	1	0	0	1	1	1	1	1	3	4	3	2	3	4	5	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr9:75531989C>T	uc004ajd.2	-	9	935	c.882G>A	c.(880-882)GGG>GGA	p.G294G	ALDH1A1_uc011lsh.1_Silent_p.G215G|ALDH1A1_uc011lsg.1_Silent_p.G120G	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	294					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GGTAGAATACCCCATGGTGTG	0.363													60	101					0	0	0	0	T	75531989	T	T	75531989	2	4	264	1	0	0	0	0	0	0	0	1	490	610	22	4		4	ALDH1A1	9	75531989	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	53560793	75531989	65681442	93	48163											
GABBR2	9568	broad.mit.edu	37	chr9	101216493	101216493	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactctctctcatactgctGtggagtctggaaaaacaggg	10	11	11	9	0	3	0	1	0	3	0	5	2	3	2	0	3	4	2	0	3	4	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr9:101216493G>T	uc004ays.2	-	7	1162	c.1006C>A	c.(1006-1008)CAG>AAG	p.Q336K		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	336	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	TCATACTGCTGTGGAGTCTGG	0.493													25	64					1.12875e-08	1.26327e-08	1	0	T	101216493	T	T	101216493	3	4	264	1	0	0	0	0	1	0	0	0	6190	1386	48	4	1871	4	GABBR2	9	101216493	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	25684504	101216493	39996938	94	48164											
MUSK	4593	broad.mit.edu	37	chr9	113445040	113445040	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcagtggaatcctaccccCagcctgagatttcctggact	8	10	10	13	0	0	1	0	1	0	1	2	4	2	3	5	2	3	1	5	2	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr9:113445040C>A	uc004bey.2	+	2	264	c.166C>A	c.(166-168)CAG>AAG	p.Q56K	MUSK_uc004bex.2_Missense_Mutation_p.Q56K	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	56	Ig-like 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						ATCCTACCCCCAGCCTGAGAT	0.333													11	115					0.000673444	0.000689402	1	0	A	113445040	A	A	113445040	3	1	264	1	0	0	0	0	1	0	0	0	10042	595	21	4	172	4	MUSK	9	113445040	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	12228547	113445040	27768391	95	48165											
MAPKAP1	79109	broad.mit.edu	37	chr9	128206807	128206807	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatttcattgacggtagcAgcgtccgattcaaagtagag	13	10	10	8	3	2	2	2	1	0	1	3	3	3	2	1	1	2	3	1	1	4	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr9:128206807A>G	uc004bpv.2	-	11	1749	c.1416T>C	c.(1414-1416)GCT>GCC	p.A472A	MAPKAP1_uc011lzt.1_Silent_p.A275A|MAPKAP1_uc010mwz.2_RNA|MAPKAP1_uc011lzu.1_Silent_p.A275A|MAPKAP1_uc011lzv.1_Silent_p.A180A|MAPKAP1_uc004bpw.2_Silent_p.A280A|MAPKAP1_uc004bpx.2_Silent_p.A280A|MAPKAP1_uc004bpy.2_Silent_p.A436A|MAPKAP1_uc004bpz.2_Silent_p.A425A|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc004bpu.2_RNA	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	472	Interaction with ATF2.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						TGACGGTAGCAGCGTCCGATT	0.473													53	93					0	0	0	0	G	128206807	G	G	128206807	2	3	264	1	0	0	0	0	0	0	0	1	9341	175	7	5		5	MAPKAP1	9	128206807	Silent	SNP	A	TCGA-CV-7432-01A-11D-2129-08	14761767	128206807	13006624	96	48166											
FAM102A	399665	broad.mit.edu	37	chr9	130707135	130707135	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgcatcgatccgcgtgtcGtccacccaggtcgggtggct	4	9	13	15	6	0	0	0	0	0	0	6	1	3	0	4	3	0	2	4	3	0	0	rs139831125		TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr9:130707135G>T	uc004bsx.1	-	9	1039	c.960C>A	c.(958-960)GAC>GAA	p.D320E	FAM102A_uc004bsw.1_Missense_Mutation_p.D178E|FAM102A_uc004bsy.1_Missense_Mutation_p.D48E	NM_001035254	NP_001030331	Q5T9C2	F102A_HUMAN	early estrogen-induced gene 1 protein isoform a	320										ovary(1)	1						TCCGCGTGTCGTCCACCCAGG	0.617													10	34					7.48243e-07	8.08102e-07	1	0	T	130707135	T	T	130707135	3	4	264	1	0	0	0	0	1	0	0	0	5410	1136	40	3	206	3	FAM102A	9	130707135	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	2500328	130707135	10506296	97	48167											
BARHL1	56751	broad.mit.edu	37	chr9	135462840	135462840	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgcagctggagcgcagcttCgagcggcagaagtacctgag	9	5	16	11	4	0	2	0	1	0	1	1	4	0	3	1	2	5	6	1	2	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr9:135462840C>T	uc004cbp.1	+	2	783	c.591C>T	c.(589-591)TTC>TTT	p.F197F		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	197	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		AGCGCAGCTTCGAGCGGCAGA	0.657													10	20					0	0	0	0	T	135462840	T	T	135462840	2	4	264	1	0	0	0	0	0	0	0	1	1315	883	31	1		1	BARHL1	9	135462840	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	4755705	135462840	5750591	98	48168											
SURF4	6836	broad.mit.edu	37	chr9	136234283	136234283	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctgatcagacagaggcgCgccacgtggggcaggtactg	8	6	17	10	3	1	3	1	1	0	2	1	3	1	3	1	4	2	3	1	4	1	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr9:136234283C>T	uc004cdj.2	-	2	217	c.87G>A	c.(85-87)GCG>GCA	p.A29A	SURF4_uc011mda.1_Silent_p.A20A|SURF4_uc010nal.2_Silent_p.A61A|SURF4_uc011mdb.1_5'UTR|SURF4_uc011mdc.1_5'UTR|SURF4_uc011mdd.1_Silent_p.A29A	NM_033161	NP_149351	O15260	SURF4_HUMAN	surfeit 4	29						endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		GACAGAGGCGCGCCACGTGGG	0.642													6	62					0	0	0	0	T	136234283	T	T	136234283	2	4	264	1	0	0	0	0	0	0	0	1	15471	755	27	1		1	SURF4	9	136234283	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	771443	136234283	4979148	99	48169											
CUBN	8029	broad.mit.edu	37	chr10	16949520	16949520	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acattacctgcatcttcactGgaggtataggaagcagtgaa	13	10	10	8	0	2	1	1	1	1	0	2	3	2	3	1	3	3	3	1	3	5	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr10:16949520G>T	uc001ioo.2	-	49	7744	c.7692C>A	c.(7690-7692)TCC>TCA	p.S2564S	CUBN_uc009xjq.1_Intron|CUBN_uc009xjr.1_Intron	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2564	CUB 18.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CATCTTCACTGGAGGTATAGG	0.463													11	48					4.3838e-07	4.78233e-07	1	0	T	16949520	T	T	16949520	2	4	264	1	0	0	0	0	0	0	0	1	4068	1335	47	4		4	CUBN	10	16949520	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08		16949520	118585227	100	48170											
SPAG6	9576	broad.mit.edu	37	chr10	22676869	22676869	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtctgaaggacaaggatgaaTacgtgaagaaaaatgcttct	16	9	11	5	1	2	4	0	3	2	1	2	6	2	6	0	2	2	1	0	2	7	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr10:22676869T>A	uc001iri.2	+	6	938	c.796T>A	c.(796-798)TAC>AAC	p.Y266N	SPAG6_uc001irj.2_Missense_Mutation_p.Y266N|SPAG6_uc010qct.1_Missense_Mutation_p.Y236N|SPAG6_uc009xkh.2_Missense_Mutation_p.Y244N	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	266	ARM 6.				cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						CAAGGATGAATACGTGAAGAA	0.373													19	39					0	0	0	0	A	22676869	A	A	22676869	3	1	264	1	0	0	0	0	1	0	0	0	15048	1406	49	5	818	5	SPAG6	10	22676869	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	5727349	22676869	112857878	101	48171											
ZNF33B	7582	broad.mit.edu	37	chr10	43088789	43088789	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtattgtgaggtctgactTcaagcagaaggttttcccac	10	13	10	8	0	2	3	1	2	1	1	3	3	3	3	1	2	1	3	1	2	3	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr10:43088789T>C	uc001jaf.1	-	5	1724	c.1609A>G	c.(1609-1611)AAG>GAG	p.K537E	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.K425E|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	537	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGGTCTGACTTCAAGCAGAAG	0.423													27	110					0	0	0	0	C	43088789	C	C	43088789	3	2	264	1	0	0	0	0	1	0	0	0	17922	1792	62	5	731	5	ZNF33B	10	43088789	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	20411920	43088789	92445958	102	48172											
SFTPD	6441	broad.mit.edu	37	chr10	81697729	81697729	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgggctcccctggggcccagTtggaatagaccagggactct	7	8	14	12	0	1	1	0	0	1	1	2	3	2	3	4	5	0	2	4	5	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr10:81697729T>C	uc001kbh.2	-	8	1050	c.1007A>G	c.(1006-1008)AAC>AGC	p.N336S	MBL1P_uc001kbf.2_Intron	NM_003019	NP_003010	P35247	SFTPD_HUMAN	pulmonary surfactant-associated protein D	336	C-type lectin.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			skin(1)	1	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			TGGGGCCCAGTTGGAATAGAC	0.552													25	145					0	0	0	0	C	81697729	C	C	81697729	3	2	264	1	0	0	0	0	1	0	0	0	14258	1725	60	5	124	5	SFTPD	10	81697729	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	38608940	81697729	53837018	103	48173											
PPP2R2D	55844	broad.mit.edu	37	chr10	133758916	133758916	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtagcaaagggaccatccGcctgtgtgacatgcgctcct	9	8	11	13	2	0	1	0	1	0	0	2	2	2	2	4	1	2	3	4	1	2	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr10:133758916G>A	uc001lks.2	+	5	917	c.674G>A	c.(673-675)CGC>CAC	p.R225H	PPP2R2D_uc001lkr.2_Missense_Mutation_p.R31H|PPP2R2D_uc001lkt.2_Missense_Mutation_p.R31H|PPP2R2D_uc009yay.2_Missense_Mutation_p.R93H	NM_018461	NP_060931	Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B,	258	WD 4.				cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			skin(1)	1		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		GGGACCATCCGCCTGTGTGAC	0.468													20	46					0	0	0	0	A	133758916	A	A	133758916	3	1	264	1	0	0	0	0	1	0	0	0	12447	1087	38	1	693	1	PPP2R2D	10	133758916	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	52061187	133758916	1775831	104	48174											
TAF10	6881	broad.mit.edu	37	chr11	6632501	6632501	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcattggcaatatctgagatGaatttctgggcagctaagga	12	12	11	6	0	3	2	1	2	2	1	3	4	3	3	0	3	1	3	0	3	4	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr11:6632501G>A	uc001mej.1	-	4	511	c.486C>T	c.(484-486)TTC>TTT	p.F162F		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	162					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TATCTGAGATGAATTTCTGGG	0.488													37	74					0	0	0	0	A	6632501	A	A	6632501	2	1	264	1	0	0	0	0	0	0	0	1	15580	1281	45	2		2	TAF10	11	6632501	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08		6632501	128374015	105	48175											
OR5D14	219436	broad.mit.edu	37	chr11	55563785	55563785	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacctgacttctatcaccAtcttccatgggaccatcctt	8	12	4	17	0	3	1	1	1	2	0	5	2	5	2	6	1	0	0	6	1	1	4	rs149902192		TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr11:55563785A>G	uc010rim.1	+	1	754	c.754A>G	c.(754-756)ATC>GTC	p.I252V		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TTCTATCACCATCTTCCATGG	0.458													24	62					0	0	0	0	G	55563785	G	G	55563785	3	3	264	1	0	0	0	0	1	0	0	0	11209	217	8	5	756	5	OR5D14	11	55563785	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	48931284	55563785	79442731	106	48176											
OR5D18	219438	broad.mit.edu	37	chr11	55587248	55587248	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggaatattgggttgattgTgatcatcaaaatcaacccca	14	11	9	7	0	3	2	3	2	0	0	3	3	3	3	2	2	1	1	2	2	5	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr11:55587248T>A	uc010rin.1	+	1	143	c.143T>A	c.(142-144)GTG>GAG	p.V48E		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GGGTTGATTGTGATCATCAAA	0.458													69	119					0	0	0	0	A	55587248	A	A	55587248	3	1	264	1	0	0	0	0	1	0	0	0	11211	1696	59	5	145	5	OR5D18	11	55587248	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	23463	55587248	79419268	107	48177											
KCNE3	10008	broad.mit.edu	37	chr11	74168458	74168458	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggagttgtcatcacggccagGtaggctggcccgcctctctt	5	10	13	13	2	3	0	2	0	1	0	4	1	3	1	3	5	0	3	3	5	1	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr11:74168458G>A	uc001ovc.2	-	3	498	c.151C>T	c.(151-153)CCT>TCT	p.P51S	KCNE3_uc001ovd.2_Missense_Mutation_p.P51S	NM_005472	NP_005463	Q9Y6H6	KCNE3_HUMAN	potassium voltage-gated channel, Isk-related	51						integral to membrane	voltage-gated potassium channel activity			ovary(1)	1	Breast(11;2.86e-06)					TCACGGCCAGGTAGGCTGGCC	0.557													19	116					0	0	0	0	A	74168458	A	A	74168458	3	1	264	1	0	0	0	0	1	0	0	0	8063	1261	44	4	164	4	KCNE3	11	74168458	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	18581210	74168458	60838058	108	48178											
DYNC2H1	79659	broad.mit.edu	37	chr11	103175431	103175431	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttacatcttgtggtatcttgGctgccagttctggaaaaggt	8	15	11	7	0	3	0	0	0	3	0	3	1	3	1	1	4	2	3	1	4	4	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr11:103175431G>C	uc001pho.2	+	77	11508	c.11364G>C	c.(11362-11364)TGG>TGC	p.W3788C	DYNC2H1_uc001phn.1_Missense_Mutation_p.W3795C|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3788	AAA 6 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TGGTATCTTGGCTGCCAGTTC	0.378													21	645					0	0	0	0	C	103175431	C	C	103175431	3	2	264	1	0	0	0	0	1	0	0	0	4868	1212	42	4	11695	4	DYNC2H1	11	103175431	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	29006973	103175431	31831085	109	48179											
ITFG2	55846	broad.mit.edu	37	chr12	2927360	2927360	+	Frame_Shift_Del	DEL	A	-	-																															ggatgcttctgggcaccacgAgacactaatcggagaggagc																										TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr12:2927360delA	uc001qlb.1	+	4	387	c.323delA	c.(322-324)GAGfs	p.E108fs	ITFG2_uc001qla.1_Frame_Shift_Del_p.E108fs|ITFG2_uc010seb.1_Intron|ITFG2_uc010sec.1_RNA	NM_018463	NP_060933	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	108											0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GGGCACCACGAGACACTAATC	0.537													---	---	---								-	2927360	-	-	2927360	7	5	264	1	0	1	0	1	0	0	0	0	7909	304	11	0	337	0	ITFG2	12	2927360	Frame_Shift_Del	DEL	A	TCGA-CV-7432-01A-11D-2129-08		2927360	130924535	110	48180											
GALNT8	26290	broad.mit.edu	37	chr12	4854710	4854710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtatgaactggcagttgatGggtttaactgggaactctgg	10	12	14	5	0	1	2	0	2	1	0	1	3	1	3	0	4	3	4	0	4	4	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr12:4854710G>A	uc001qne.1	+	5	1068	c.976G>A	c.(976-978)GGG>AGG	p.G326R		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	326	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						GGCAGTTGATGGGTTTAACTG	0.493													11	49					0	0	0	0	A	4854710	A	A	4854710	3	1	264	1	0	0	0	0	1	0	0	0	6254	1348	47	4	994	4	GALNT8	12	4854710	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	1927350	4854710	128997185	111	48181											
ENO2	2026	broad.mit.edu	37	chr12	7028878	7028878	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccttcccgatacatcacTggggaccagctgggggcact	8	8	12	13	1	1	0	1	0	0	0	3	3	3	1	3	4	2	2	3	4	1	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr12:7028878T>A	uc001qru.1	+	8	1038	c.816T>A	c.(814-816)ACT>ACA	p.T272T	ENO2_uc009zfi.1_Silent_p.T272T|ENO2_uc010sfq.1_Silent_p.T229T|ENO2_uc001qrv.1_Silent_p.T272T	NM_001975	NP_001966	P09104	ENOG_HUMAN	enolase 2	272					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex|plasma membrane	magnesium ion binding|phosphopyruvate hydratase activity				0						GATACATCACTGGGGACCAGC	0.542													21	54					0	0	0	0	A	7028878	A	A	7028878	2	1	264	1	0	0	0	0	0	0	0	1	5146	1567	55	5		5	ENO2	12	7028878	Silent	SNP	T	TCGA-CV-7432-01A-11D-2129-08	2174168	7028878	126823017	112	48182											
SLCO1B1	10599	broad.mit.edu	37	chr12	21358894	21358894	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcaatgggaaccagtctgtgGaaacaatggaataacttaca	16	9	9	7	0	2	0	1	0	1	0	2	3	2	3	1	3	4	0	1	3	7	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr12:21358894G>C	uc001req.3	+	11	1528	c.1424G>C	c.(1423-1425)GGA>GCA	p.G475A		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	475	Extracellular (Potential).|Kazal-like.				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CCAGTCTGTGGAAACAATGGA	0.378													17	110					0	0	0	0	C	21358894	C	C	21358894	3	2	264	1	0	0	0	0	1	0	0	0	14787	1174	41	2	1462	2	SLCO1B1	12	21358894	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	14330016	21358894	112493001	113	48183											
KCNH3	23416	broad.mit.edu	37	chr12	49951243	49951243	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagggagggtccgtgccctcGggcatcgggagaggggccgt	5	5	20	11	4	0	1	0	0	0	1	3	3	1	2	3	6	1	1	3	6	0	0			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr12:49951243G>A	uc001ruh.1	+	15	3019	c.2759G>A	c.(2758-2760)CGG>CAG	p.R920Q	KCNH3_uc010smj.1_Missense_Mutation_p.R860Q	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	920	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						CCGTGCCCTCGGGCATCGGGA	0.677													4	18					0	0	0	0	A	49951243	A	A	49951243	3	1	264	1	0	0	0	0	1	0	0	0	8072	1116	39	1	2817	1	KCNH3	12	49951243	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	28592349	49951243	83900652	114	48184											
KRT5	3852	broad.mit.edu	37	chr12	52909018	52909018	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaggaaacactgcttgtgAcaacagctgcagggaaagga	15	5	13	8	0	0	2	0	1	0	1	0	5	0	5	0	3	5	3	0	3	3	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr12:52909018A>T	uc001san.2	-	9	1644	c.1481T>A	c.(1480-1482)GTC>GAC	p.V494D		NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	494	Tail.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACTGCTTGTGACAACAGCTGC	0.323													12	26					0	0	0	0	T	52909018	T	T	52909018	3	4	264	1	0	0	0	0	1	0	0	0	8518	275	10	5	295	5	KRT5	12	52909018	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	2957775	52909018	80942877	115	48185											
FAM119B	25895	broad.mit.edu	37	chr12	58166597	58166597	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagactcttactcggagaaGagccagttctgtttctgtgg	8	12	12	9	1	3	3	0	0	3	3	4	4	3	3	1	2	2	3	1	2	2	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr12:58166597G>C	uc001sqg.2	+	1	215	c.90G>C	c.(88-90)AAG>AAC	p.K30N	METTL1_uc010ssd.1_5'Flank|METTL1_uc009zqc.2_5'Flank|FAM119B_uc001sqf.2_Missense_Mutation_p.K30N|FAM119B_uc009zqd.2_RNA	NM_015433	NP_056248	Q96AZ1	MT21B_HUMAN	hypothetical protein LOC25895 isoform a	30						integral to membrane|intracellular	methyltransferase activity				0	all_cancers(7;9.07e-82)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					ACTCGGAGAAGAGCCAGTTCT	0.652													16	42					0	0	0	0	C	58166597	C	C	58166597	3	2	264	1	0	0	0	0	1	0	0	0	5442	933	33	2	92	2	FAM119B	12	58166597	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	5257579	58166597	75685298	116	48186											
OAS2	4939	broad.mit.edu	37	chr12	113435452	113435452	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaggcgtcagaaccgtacTggagctgatcaaatgccagg	12	7	13	9	2	2	3	2	2	0	1	2	4	2	4	2	3	4	2	2	3	4	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr12:113435452T>A	uc001tuj.2	+	4	895	c.755T>A	c.(754-756)CTG>CAG	p.L252Q	OAS2_uc001tui.1_Missense_Mutation_p.L252Q	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	252	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						AGAACCGTACTGGAGCTGATC	0.502													16	41					0	0	0	0	A	113435452	A	A	113435452	3	1	264	1	0	0	0	0	1	0	0	0	10854	1580	55	5	840	5	OAS2	12	113435452	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	55268855	113435452	20416443	117	48187											
ULK1	8408	broad.mit.edu	37	chr12	132401102	132401102	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccgttgggccctggcctgCggccaggcgaggaccccaag	6	4	16	15	3	0	0	0	0	0	0	0	2	0	1	6	5	2	1	6	5	1	1	rs147399196	byFrequency	TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr12:132401102C>T	uc001uje.2	+	20	2306	c.2038C>T	c.(2038-2040)CGG>TGG	p.R680W		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	680					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CCCTGGCCTGCGGCCAGGCGA	0.687													5	47					0	0	0	0	T	132401102	T	T	132401102	3	4	264	1	0	0	0	0	1	0	0	0	17043	759	27	1	2116	1	ULK1	12	132401102	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	18965650	132401102	1450793	118	48188											
POSTN	10631	broad.mit.edu	37	chr13	38137487	38137487	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttttcactgagaacgaccttCccttaatcgtcttctagatc	9	15	5	12	2	3	2	1	1	2	2	6	4	4	2	2	0	1	0	2	0	3	6			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr13:38137487C>T	uc001uwo.3	-	23	2612	c.2494G>A	c.(2494-2496)GAA>AAA	p.E832K	POSTN_uc010tet.1_Missense_Mutation_p.E333K|POSTN_uc001uwp.3_Missense_Mutation_p.E775K|POSTN_uc001uwr.2_Missense_Mutation_p.E777K|POSTN_uc001uwq.2_Missense_Mutation_p.E747K	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	832					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GAACGACCTTCCCTTAATCGT	0.299													16	39					0	0	0	0	T	38137487	T	T	38137487	3	4	264	1	0	0	0	0	1	0	0	0	12314	864	30	2	20	2	POSTN	13	38137487	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08		38137487	77032391	119	48189											
CYSLTR2	57105	broad.mit.edu	37	chr13	49281497	49281497	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acagtggctctgagcagaacGgcagtgtcacatcatgctta	11	9	11	10	1	3	2	2	1	1	1	3	2	3	2	0	2	3	4	0	2	2	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr13:49281497G>A	uc010acx.1	+	6	1227	c.544G>A	c.(544-546)GGC>AGC	p.G182S	CYSLTR2_uc010acy.1_Missense_Mutation_p.G182S|CYSLTR2_uc010acz.1_Missense_Mutation_p.G182S|CYSLTR2_uc010ada.1_Missense_Mutation_p.G182S|CYSLTR2_uc010adb.1_Missense_Mutation_p.G182S|CYSLTR2_uc010adc.1_Missense_Mutation_p.G182S|CYSLTR2_uc010add.1_Missense_Mutation_p.G182S|CYSLTR2_uc010acw.1_Missense_Mutation_p.G182S|CYSLTR2_uc001vck.2_Missense_Mutation_p.G182S	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	182	Extracellular (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TGAGCAGAACGGCAGTGTCAC	0.483													39	122					0	0	0	0	A	49281497	A	A	49281497	3	1	264	1	0	0	0	0	1	0	0	0	4219	1116	39	1	546	1	CYSLTR2	13	49281497	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	11144010	49281497	65888381	120	48190											
DIAPH3	81624	broad.mit.edu	37	chr13	60485887	60485887	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacaaccacaaactgctcAggttcacataagttgctata	15	9	5	12	0	2	0	2	0	0	0	2	0	2	0	2	1	4	4	2	1	5	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr13:60485887A>T	uc001vht.2	-	20	2568	c.2349T>A	c.(2347-2349)CCT>CCA	p.P783P	DIAPH3_uc001vhu.2_Silent_p.P520P|DIAPH3_uc001vhv.2_Silent_p.P361P	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	783	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		CAAACTGCTCAGGTTCACATA	0.348													30	56					0	0	0	0	T	60485887	T	T	60485887	2	4	264	1	0	0	0	0	0	0	0	1	4542	175	7	5		5	DIAPH3	13	60485887	Silent	SNP	A	TCGA-CV-7432-01A-11D-2129-08	11204390	60485887	54683991	121	48191											
GPC5	2262	broad.mit.edu	37	chr13	92797193	92797193	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgatgatgaagatggttgCgggggatcaggaagtggaga	11	9	19	2	1	1	5	1	3	0	2	1	8	1	7	0	5	1	1	0	5	2	1	rs147244156		TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr13:92797193C>T	uc010tif.1	+	7	1878	c.1512C>T	c.(1510-1512)TGC>TGT	p.C504C		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	504						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AAGATGGTTGCGGGGGATCAG	0.443													16	62					0	0	0	0	T	92797193	T	T	92797193	2	4	264	1	0	0	0	0	0	0	0	1	6639	776	27	1		1	GPC5	13	92797193	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	32311306	92797193	22372685	122	48192											
TTC5	91875	broad.mit.edu	37	chr14	20768886	20768886	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagcttcacagcctttgaCagaagctcctcagccttagg	9	10	8	14	0	2	2	2	1	0	1	4	2	4	2	4	1	4	2	4	1	2	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr14:20768886C>A	uc001vwt.2	-	3	333	c.276G>T	c.(274-276)CTG>CTT	p.L92L	TTC5_uc001vwu.2_5'UTR	NM_138376	NP_612385	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	92	TPR 1.				DNA repair	cytoplasm|nucleus	binding			ovary(1)	1	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		CAGCCTTTGACAGAAGCTCCT	0.532													62	64					4.17052e-40	5.06085e-40	1	0	A	20768886	A	A	20768886	2	1	264	1	0	0	0	0	0	0	0	1	16779	465	17	4		4	TTC5	14	20768886	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08		20768886	86580654	123	48193											
JUB	84962	broad.mit.edu	37	chr14	23450599	23450599	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgcgggctccggcttctcGcccaccggtgcccaccgtca	3	7	11	20	6	2	0	1	0	1	0	5	0	4	0	6	3	1	2	6	3	0	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr14:23450599G>A	uc001whz.2	-	1	1253	c.877C>T	c.(877-879)CGA>TGA	p.R293*		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	293	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CCGGCTTCTCGCCCACCGGTG	0.706													10	10					0	0	0	0	A	23450599	A	A	23450599	4	1	264	1	0	0	0	0	0	1	0	0	8007	1095	38	1	771	1	JUB	14	23450599	Nonsense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	2681713	23450599	83898941	124	48194											
C14orf105	55195	broad.mit.edu	37	chr14	57938276	57938276	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtagttattcactgcttGatgtttcaaaaattctgtat	12	17	6	6	0	3	1	2	1	1	0	3	1	3	1	0	0	1	5	0	0	5	7			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr14:57938276G>T	uc001xcy.2	-	6	831	c.688C>A	c.(688-690)CAA>AAA	p.Q230K	C14orf105_uc010trl.1_Missense_Mutation_p.Q270K|C14orf105_uc010trm.1_Missense_Mutation_p.Q141K|C14orf105_uc010trn.1_Missense_Mutation_p.Q141K|C14orf105_uc001xcz.2_Missense_Mutation_p.Q229K	NM_018168	NP_060638	Q9NVL8	CN105_HUMAN	hypothetical protein LOC55195	230											0						TTCACTGCTTGATGTTTCAAA	0.358													12	21					1.61879e-10	1.83068e-10	1	0	T	57938276	T	T	57938276	3	4	264	1	0	0	0	0	1	0	0	0	1743	1299	45	2	206	2	C14orf105	14	57938276	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	34487677	57938276	49411264	125	48195											
SIPA1L1	26037	broad.mit.edu	37	chr14	72054661	72054661	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctctgttgttggcacagaCggcacccccaaagtccacac	9	7	9	16	1	1	1	0	0	1	1	2	1	2	1	4	2	0	4	4	2	1	2	rs112129340		TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr14:72054661C>T	uc001xms.2	+	2	420	c.72C>T	c.(70-72)GAC>GAT	p.D24D	SIPA1L1_uc001xmt.2_Silent_p.D24D|SIPA1L1_uc001xmu.2_Silent_p.D24D|SIPA1L1_uc001xmv.2_Silent_p.D24D	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	24					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TTGGCACAGACGGCACCCCCA	0.522													48	93					0	0	0	0	T	72054661	T	T	72054661	2	4	264	1	0	0	0	0	0	0	0	1	14394	535	19	1		1	SIPA1L1	14	72054661	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	14116385	72054661	35294879	126	48196											
NRXN3	9369	broad.mit.edu	37	chr14	80328189	80328189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctatcaagtggacgagaCgcggaactacatcagcaact	13	7	10	11	3	2	1	2	0	0	1	3	4	3	3	1	2	4	1	1	2	5	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr14:80328189C>T	uc001xun.2	+	17	3559	c.3068C>T	c.(3067-3069)ACG>ATG	p.T1023M	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.T599M|NRXN3_uc010asw.2_Missense_Mutation_p.T421M|NRXN3_uc001xur.3_Missense_Mutation_p.T394M	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1605	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GTGGACGAGACGCGGAACTAC	0.562													8	18					0	0	0	0	T	80328189	T	T	80328189	3	4	264	1	0	0	0	0	1	0	0	0	10721	536	19	1	3480	1	NRXN3	14	80328189	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	8273528	80328189	27021351	127	48197											
FLRT2	23768	broad.mit.edu	37	chr14	86088735	86088735	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaactgcggatgctgactCaaggggtttttgataatctc	10	12	10	9	1	2	2	1	2	1	0	3	3	2	3	1	3	3	2	1	3	3	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr14:86088735C>G	uc001xvr.2	+	2	1644	c.877C>G	c.(877-879)CAA>GAA	p.Q293E	FLRT2_uc010atd.2_Missense_Mutation_p.Q293E	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	293	Extracellular (Potential).|LRR 10.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GATGCTGACTCAAGGGGTTTT	0.463													75	205					0	0	0	0	G	86088735	G	G	86088735	3	3	264	1	0	0	0	0	1	0	0	0	5971	827	29	2	879	2	FLRT2	14	86088735	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	5760546	86088735	21260805	128	48198											
TYRO3	7301	broad.mit.edu	37	chr15	41857341	41857342	+	Splice_Site	INS	-	A	A																															cagtcctgtacagttcaggtINSaggctctccgggccgggcca																										TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr15:41857341_41857342insA	uc001zof.1	+	6	1007	c.783_splice	c.e6+2	p.Q261_splice		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor							integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		ACAGTTCAGGTAGGCTCTCCGG	0.579													---	---	---								A	41857342	A	A	41857341	8	5	264	1	0	1	1	0	0	0	1	0	16882	1652	57	0	807	0	TYRO3	15	41857341	Splice_Site	INS	-	TCGA-CV-7432-01A-11D-2129-08		41857341	60674051	129	48199											
CAPN3	825	broad.mit.edu	37	chr15	42693865	42693865	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggaccaaccctcagtacCgtctgaagctcctggaggag	9	8	11	13	1	3	1	1	1	2	0	4	4	4	4	4	3	3	2	4	3	3	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr15:42693865C>T	uc001zpn.1	+	11	1687	c.1381C>T	c.(1381-1383)CGT>TGT	p.R461C	CAPN3_uc001zpk.1_Missense_Mutation_p.R234C|CAPN3_uc001zpl.1_Missense_Mutation_p.R374C|CAPN3_uc010udf.1_Missense_Mutation_p.R374C|CAPN3_uc010udg.1_Missense_Mutation_p.R326C|CAPN3_uc001zpo.1_Missense_Mutation_p.R461C|CAPN3_uc001zpp.1_Missense_Mutation_p.R413C|CAPN3_uc001zpq.1_5'Flank	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	461	Domain III.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CCCTCAGTACCGTCTGAAGCT	0.582													7	24					0	0	0	0	T	42693865	T	T	42693865	3	4	264	1	0	0	0	0	1	0	0	0	2640	652	23	1	1475	1	CAPN3	15	42693865	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	836524	42693865	59837527	130	48200											
LINS1	55180	broad.mit.edu	37	chr15	101120487	101120487	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttttctctcaattggaaaTatagaagcaatgcaaggcac	14	11	7	9	0	2	1	1	0	1	1	3	2	2	2	1	2	2	3	1	2	7	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr15:101120487T>G	uc002bwe.2	-	4	761	c.470A>C	c.(469-471)TAT>TCT	p.Y157S	LINS1_uc002bwf.2_Missense_Mutation_p.Y157S|LINS1_uc002bwg.2_Missense_Mutation_p.Y157S|LINS1_uc002bwh.2_Missense_Mutation_p.Y157S|LINS1_uc010usa.1_Missense_Mutation_p.Y38S|LINS1_uc002bwi.2_Missense_Mutation_p.Y157S	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	157											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			CAATTGGAAATATAGAAGCAA	0.254													9	17					0	0	0	0	G	101120487	G	G	101120487	3	3	264	1	0	0	0	0	1	0	0	0	8860	1406	49	5	1823	5	LINS1	15	101120487	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	58426622	101120487	1410905	131	48201											
PKD1	5310	broad.mit.edu	37	chr16	2143887	2143888	+	Frame_Shift_Ins	INS	-	G	G																															gccacgcaacactcacgcccINSggggggaagctcgcacccac																										TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr16:2143887_2143888insG	uc002cos.1	-	36	10954_10955	c.10745_10746insC	c.(10744-10746)CCGfs	p.P3582fs	PKD1_uc002cot.1_Frame_Shift_Ins_p.P3581fs|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	3582	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CACTCACGCCCGGGGGGAAGCT	0.698													---	---	---								G	2143888	G	G	2143887	7	5	264	1	0	1	1	0	0	0	0	0	12018	639	23	0	2209	0	PKD1	16	2143887	Frame_Shift_Ins	INS	-	TCGA-CV-7432-01A-11D-2129-08		2143887	88210866	132	48202											
ACSM2B	348158	broad.mit.edu	37	chr16	20554275	20554275	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgctgatcacagccgtCtcaaccacagcagggtgctt	8	8	12	13	1	2	1	2	1	1	0	3	1	2	1	2	2	5	4	2	2	1	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr16:20554275C>A	uc002dhj.3	-	13	1680	c.1470G>T	c.(1468-1470)GAG>GAT	p.E490D	ACSM2B_uc002dhk.3_Missense_Mutation_p.E490D|ACSM2B_uc010bwf.1_Missense_Mutation_p.E490D	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	490					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding	p.E490A(1)		skin(3)|ovary(1)|central_nervous_system(1)	5						TCACAGCCGTCTCAACCACAG	0.522													15	60					1.15088e-07	1.26831e-07	1	0	A	20554275	A	A	20554275	3	1	264	1	0	0	0	0	1	0	0	0	184	912	32	2	275	2	ACSM2B	16	20554275	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	18410388	20554275	69800478	133	48203											
CDH8	1006	broad.mit.edu	37	chr16	61687870	61687870	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattttgtaaagttgcaatgTcaaaagcctctgtgtcctcc	10	14	8	9	0	2	0	1	0	1	0	4	1	4	0	3	0	2	3	3	0	5	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr16:61687870T>A	uc002eog.1	-	12	2294	c.2042A>T	c.(2041-2043)GAC>GTC	p.D681V		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	681	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AGTTGCAATGTCAAAAGCCTC	0.398													43	88					0	0	0	0	A	61687870	A	A	61687870	3	1	264	1	0	0	0	0	1	0	0	0	3131	1667	58	5	361	5	CDH8	16	61687870	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	41133595	61687870	28666883	134	48204											
EXOC3L	283849	broad.mit.edu	37	chr16	67218811	67218811	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagaagctctcaccaaactGaggaaaagctgctgaagctg	15	6	10	10	0	1	3	1	2	1	1	2	4	1	4	1	1	5	4	1	1	6	0			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr16:67218811G>A	uc002erx.1	-	12	2140	c.1899C>T	c.(1897-1899)CTC>CTT	p.L633L	KIAA0895L_uc002ert.2_5'Flank|KIAA0895L_uc002eru.2_5'Flank|EXOC3L_uc002erv.1_RNA|EXOC3L_uc002erw.1_Silent_p.L284L|EXOC3L_uc002ery.1_Silent_p.L535L|EXOC3L_uc010vje.1_Silent_p.L530L	NM_178516	NP_848611	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like	633					exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0021)|Epithelial(162;0.0073)|all cancers(182;0.0616)		TCACCAAACTGAGGAAAAGCT	0.687													3	18					0	0	0	0	A	67218811	A	A	67218811	2	1	264	1	0	0	0	0	0	0	0	1	5328	1277	45	2		2	EXOC3L	16	67218811	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	5530941	67218811	23135942	135	48205											
TMCO7	79613	broad.mit.edu	37	chr16	68894425	68894425	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgctaacacctgcagaaGaggtaaatatacattgagaa	18	8	8	7	0	0	3	0	1	0	3	0	4	0	3	1	1	5	3	1	1	8	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr16:68894425G>T	uc002ewi.3	+	2	745	c.733G>T	c.(733-735)GAG>TAG	p.E245*	TMCO7_uc002ewh.2_Nonsense_Mutation_p.E245*	NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	245						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		ACCTGCAGAAGAGGTAAATAT	0.428													14	40					1.5842e-08	1.76385e-08	1	0	T	68894425	T	T	68894425	4	4	264	1	0	0	0	0	0	1	0	0	16067	943	33	2	739	2	TMCO7	16	68894425	Nonsense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	1675614	68894425	21460328	136	48206											
ZFHX3	463	broad.mit.edu	37	chr16	72993956	72993956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgggtttgtcagggaggtggGtgctgttgagttcagtccat	5	14	17	5	0	2	1	2	1	0	0	3	2	3	2	1	4	1	4	1	4	0	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr16:72993956G>A	uc002fck.2	-	2	762	c.89C>T	c.(88-90)ACC>ATC	p.T30I	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	30					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				AGGGAGGTGGGTGCTGTTGAG	0.627													17	59					0	0	0	0	A	72993956	A	A	72993956	3	1	264	1	0	0	0	0	1	0	0	0	17701	1261	44	4	11058	4	ZFHX3	16	72993956	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	4099531	72993956	17360797	137	48207											
LDHD	197257	broad.mit.edu	37	chr16	75148731	75148731	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttcgcgagtcctacccacggGaaaccagaggccgctgtccc	8	6	11	16	4	0	1	0	0	0	1	3	3	2	2	5	2	2	1	5	2	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr16:75148731G>T	uc002fdm.2	-	4	510	c.463C>A	c.(463-465)CCC>ACC	p.P155T	LDHD_uc002fdn.2_Missense_Mutation_p.P155T	NM_153486	NP_705690	Q86WU2	LDHD_HUMAN	D-lactate dehydrogenase isoform 1 precursor	155	FAD-binding PCMH-type.						D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding				0						CTACCCACGGGAAACCAGAGG	0.657													9	32					1.76689e-08	1.95717e-08	1	0	T	75148731	T	T	75148731	3	4	264	1	0	0	0	0	1	0	0	0	8743	1174	41	2	1092	2	LDHD	16	75148731	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	2154775	75148731	15206022	138	48208											
ATP2A3	489	broad.mit.edu	37	chr17	3853822	3853822	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagaaaacagcatgttctTcttgtcctggttcacagctc	10	13	7	11	0	3	1	1	0	2	1	5	1	4	1	1	1	4	4	1	1	3	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr17:3853822T>C	uc002fxb.1	-	7	764	c.613A>G	c.(613-615)AAG>GAG	p.K205E	ATP2A3_uc002fwx.1_Missense_Mutation_p.K205E|ATP2A3_uc002fwy.1_Missense_Mutation_p.K205E|ATP2A3_uc002fwz.1_Missense_Mutation_p.K205E|ATP2A3_uc002fxa.1_Missense_Mutation_p.K205E|ATP2A3_uc002fxc.1_Missense_Mutation_p.K205E|ATP2A3_uc002fxd.1_Missense_Mutation_p.K205E	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	205	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		AGCATGTTCTTCTTGTCCTGG	0.428													12	71					0	0	0	0	C	3853822	C	C	3853822	3	2	264	1	0	0	0	0	1	0	0	0	1140	1792	62	5	2657	5	ATP2A3	17	3853822	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08		3853822	77341388	139	48209											
FXR2	9513	broad.mit.edu	37	chr17	7495898	7495898	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cggcggctgcgattacgacgTtgaggtcttgattcatcttc	6	13	12	10	5	3	2	1	2	2	0	4	4	3	2	0	3	2	2	0	3	1	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr17:7495898T>C	uc002gia.1	-	15	1976	c.1749A>G	c.(1747-1749)CAA>CAG	p.Q583Q	MPDU1_uc010vuc.1_3'UTR|SOX15_uc002ghy.1_5'Flank|SOX15_uc002ghz.1_5'Flank	NM_004860	NP_004851	P51116	FXR2_HUMAN	fragile X mental retardation syndrome related	583						cytosolic large ribosomal subunit	protein binding|RNA binding				0				READ - Rectum adenocarcinoma(115;0.17)		GATTACGACGTTGAGGTCTTG	0.542													49	125					0	0	0	0	C	7495898	C	C	7495898	2	2	264	1	0	0	0	0	0	0	0	1	6150	1722	60	5		5	FXR2	17	7495898	Silent	SNP	T	TCGA-CV-7432-01A-11D-2129-08	3642076	7495898	73699312	140	48210											
TP53	7157	broad.mit.edu	37	chr17	7577554	7577564	+	Frame_Shift_Del	DEL	TGCAGGAACTG	-	-																															cctccggttcatgccgcccaTgcaggaactgttacacatgt																								rs121912655		TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr17:7577554_7577564delTGCAGGAACTG	uc002gim.2	-	7	911_921	c.717_727delCAGTTCCTGCA	c.(715-729)AACAGTTCCTGCATGfs	p.N239fs	TP53_uc002gig.1_Frame_Shift_Del_p.N239fs|TP53_uc002gih.2_Frame_Shift_Del_p.N239fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.N107fs|TP53_uc010cng.1_Frame_Shift_Del_p.N107fs|TP53_uc002gii.1_Frame_Shift_Del_p.N107fs|TP53_uc010cnh.1_Frame_Shift_Del_p.N239fs|TP53_uc010cni.1_Frame_Shift_Del_p.N239fs|TP53_uc002gij.2_Frame_Shift_Del_p.N239fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.N146fs|TP53_uc002gio.2_Frame_Shift_Del_p.N107fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	239_243	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		M -> L (in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> I (in sporadic cancers; somatic mutation).|M -> R (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|MG -> IC (in a sporadic cancer; somatic mutation).|MG -> IS (in a sporadic cancer; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(73)|p.C242F(63)|p.C242Y(37)|p.N239D(31)|p.C242S(25)|p.S241C(24)|p.N239S(19)|p.C242fs*5(16)|p.S240G(14)|p.N239fs*25(12)|p.C242R(11)|p.M243L(10)|p.S240R(8)|p.S241fs*6(8)|p.C242W(7)|p.0?(7)|p.S241Y(7)|p.N239Y(6)|p.N239K(6)|p.S240I(6)|p.S241A(6)|p.S241del(5)|p.S241T(5)|p.N239T(4)|p.N239_C242delNSSC(3)|p.M243V(3)|p.C242*(3)|p.S241S(3)|p.S240C(3)|p.S241P(3)|p.N239_S240insX(2)|p.N239fs*8(2)|p.S240S(2)|p.S240T(2)|p.C242C(2)|p.C242G(2)|p.S240fs*7(2)|p.N239_S240delNS(2)|p.S241fs*22(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.N239fs*26(1)|p.Y236_M243delYMCNSSCM(1)|p.N239fs*1(1)|p.N239_S240insN(1)|p.V225fs*23(1)|p.N239fs*6(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.S240>CSC(1)|p.C238_M246delCNSSCMGGM(1)|p.S240P(1)|p.S241_C242insX(1)|p.M243fs*4(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.N239N(1)|p.M243fs*18(1)|p.H233fs*6(1)|p.S241fs*7(1)|p.S240fs*26(1)|p.N239*(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241fs*23(1)|p.S241_G245delSCMGG(1)|p.N239fs*0(1)|p.S240fs*23(1)|p.C238_N239insX(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGCCGCCCATGCAGGAACTGTTACACATGT	0.583		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7577564	-	-	7577554	7	5	264	1	0	1	0	1	0	0	0	0	16448	1464	51	0	563	0	TP53	17	7577554	Frame_Shift_Del	DEL	TGCAGGAACTG	TCGA-CV-7432-01A-11D-2129-08	81656	7577554	73617656	141	48211											
TP53	7157	broad.mit.edu	37	chr17	7579312	7579312	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccctcagggcaactgacCgtgcaagtcacagacttggc	10	6	11	14	1	2	2	2	1	0	1	2	2	2	2	3	2	3	2	3	2	2	1	rs55863639		TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr17:7579312C>A	uc002gim.2	-	4	569	c.375G>T	c.(373-375)ACG>ACT	p.T125T	TP53_uc002gig.1_Silent_p.T125T|TP53_uc002gih.2_Silent_p.T125T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Silent_p.T125T|TP53_uc010cni.1_Silent_p.T125T|TP53_uc002gij.2_Silent_p.T125T|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Silent_p.T86T|TP53_uc010cnk.1_Silent_p.T140T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	125	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in a sporadic cancer; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(15)|p.0?(7)|p.T125M(7)|p.T125K(3)|p.T125R(3)|p.?(2)|p.V73fs*9(1)|p.T125P(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.T125fs*45(1)|p.T125fs*24(1)|p.T125A(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	55					7.88262e-20	9.45915e-20	1	0	A	7579312	A	A	7579312	2	1	264	1	0	0	0	0	0	0	0	1	16448	666	23	3		3	TP53	17	7579312	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	1758	7579312	73615898	142	48212											
MYH4	4622	broad.mit.edu	37	chr17	10369620	10369620	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggctgcgtaacgctctttGaggttatacagcacagcagg	10	9	12	10	2	1	1	0	1	1	0	1	1	1	1	0	3	5	6	0	3	3	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr17:10369620G>A	uc002gmn.2	-	4	429	c.318C>T	c.(316-318)CTC>CTT	p.L106L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	106	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AACGCTCTTTGAGGTTATACA	0.453													34	92					0	0	0	0	A	10369620	A	A	10369620	2	1	264	1	0	0	0	0	0	0	0	1	10090	1277	45	2		2	MYH4	17	10369620	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	2790308	10369620	70825590	143	48213											
DBF4B	80174	broad.mit.edu	37	chr17	42828265	42828265	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggcccactcctcttccctGaagccagaccgtggcttatg	7	9	10	15	1	1	2	0	1	1	1	3	2	3	2	5	2	1	1	5	2	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr17:42828265G>A	uc002ihf.2	+	14	1705	c.1492G>A	c.(1492-1494)GAA>AAA	p.E498K	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	498					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				CCTCTTCCCTGAAGCCAGACC	0.587													20	105					0	0	0	0	A	42828265	A	A	42828265	3	1	264	1	0	0	0	0	1	0	0	0	4266	1291	45	2	1591	2	DBF4B	17	42828265	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	32458645	42828265	38366945	144	48214											
ZNF652	22834	broad.mit.edu	37	chr17	47394438	47394438	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttacgcttaggtggctctAcactcttcctacgacctctt	6	15	6	14	2	4	0	0	0	4	0	5	1	5	0	2	2	3	2	2	2	4	6			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr17:47394438A>C	uc002iov.3	-	2	1114	c.650T>G	c.(649-651)GTA>GGA	p.V217G	ZNF652_uc002iow.2_Missense_Mutation_p.V217G|ZNF652_uc002iou.3_Intron	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			AGGTGGCTCTACACTCTTCCT	0.522													19	42					0	0	0	0	C	47394438	C	C	47394438	3	2	264	1	0	0	0	0	1	0	0	0	18132	391	14	5	1190	5	ZNF652	17	47394438	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	4566173	47394438	33800772	145	48215											
ABCA8	10351	broad.mit.edu	37	chr17	66865847	66865847	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcatacttcttacccttctCtaatttgaagaaagcttggg	10	15	7	9	0	3	2	1	1	2	1	4	2	3	2	1	1	3	1	1	1	5	7			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr17:66865847C>G	uc002jhp.2	-	36	4764	c.4585G>C	c.(4585-4587)GAG>CAG	p.E1529Q	ABCA8_uc002jhq.2_Missense_Mutation_p.E1569Q|ABCA8_uc010wqq.1_Missense_Mutation_p.E1564Q	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1529						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TTACCCTTCTCTAATTTGAAG	0.363													56	128					0	0	0	0	G	66865847	G	G	66865847	3	3	264	1	0	0	0	0	1	0	0	0	38	922	32	2	172	2	ABCA8	17	66865847	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	19471409	66865847	14329363	146	48216											
CCDC40	55036	broad.mit.edu	37	chr17	78013907	78013907	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctggagaggaggcatacgaTagtgttagcggggaggctgg	9	7	19	6	2	0	1	0	0	0	1	0	5	0	3	1	7	2	3	1	7	3	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	a0228446-5e7f-437e-b15e-b7a022572d9d	g.chr17:78013907T>G	uc010dht.2	+	3	417	c.390T>G	c.(388-390)GAT>GAG	p.D130E	CCDC40_uc010wub.1_Missense_Mutation_p.D130E	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	130					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGGCATACGATAGTGTTAGCG	0.562													5	48					0	0	0	0	G	78013907	G	G	78013907	3	3	264	1	0	0	0	0	1	0	0	0	2825	1403	49	5	400	5	CCDC40	17	78013907	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	11148060	78013907	3181303	147	48217											
LRRC30	339291	broad.mit.edu	37	chr18	7231433	7231433	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgacccggatcgtggtcctGaacttgtgcgggaaccgcct	6	9	13	13	4	0	2	0	2	0	0	2	4	1	4	4	3	3	0	4	3	2	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr18:7231433G>A	uc010wzk.1	+	1	297	c.297G>A	c.(295-297)CTG>CTA	p.L99L		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	99	LRR 2.									ovary(1)|liver(1)	2						TCGTGGTCCTGAACTTGTGCG	0.577													10	29					0	0	0	0	A	7231433	A	A	7231433	2	1	264	1	0	0	0	0	0	0	0	1	9035	1277	45	2		2	LRRC30	18	7231433	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08		7231433	70845815	148	48218											
ANKRD12	23253	broad.mit.edu	37	chr18	9256801	9256801	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgactttagggaagtcatCttttgtttcagataatagct	12	16	8	5	0	3	2	2	1	1	1	3	3	3	3	0	1	1	2	0	1	5	7			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr18:9256801C>G	uc002knv.2	+	9	3793	c.3536C>G	c.(3535-3537)TCT>TGT	p.S1179C	ANKRD12_uc002knw.2_Missense_Mutation_p.S1156C|ANKRD12_uc002knx.2_Missense_Mutation_p.S1156C|ANKRD12_uc010dkx.1_Missense_Mutation_p.S886C	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1179						nucleus				ovary(2)|central_nervous_system(1)	3						GGGAAGTCATCTTTTGTTTCA	0.383													16	48					0	0	0	0	G	9256801	G	G	9256801	3	3	264	1	0	0	0	0	1	0	0	0	640	913	32	2	3566	2	ANKRD12	18	9256801	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	2025368	9256801	68820447	149	48219											
CCDC11	220136	broad.mit.edu	37	chr18	47777156	47777156	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttctttttatctgcctctTcctgtaagtcttgaagggcc	5	18	8	10	0	4	1	0	1	4	0	5	1	5	1	3	1	1	2	3	1	3	7			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr18:47777156T>A	uc002lee.2	-	5	1059	c.968A>T	c.(967-969)GAA>GTA	p.E323V		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	323	Potential.									ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		ATCTGCCTCTTCCTGTAAGTC	0.428													52	182					0	0	0	0	A	47777156	A	A	47777156	3	1	264	1	0	0	0	0	1	0	0	0	2758	1783	62	5	592	5	CCDC11	18	47777156	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	38520355	47777156	30300092	150	48220											
PIGN	23556	broad.mit.edu	37	chr18	59742026	59742026	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttaccaaagccataatgtCtgatatgacgagaacaatga	16	9	7	9	1	1	4	0	3	1	1	1	5	1	4	3	0	3	0	3	0	6	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr18:59742026C>A	uc002lii.3	-	30	3053	c.2605G>T	c.(2605-2607)GAC>TAC	p.D869Y	PIGN_uc002lij.3_Missense_Mutation_p.D869Y	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	869	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				GCCATAATGTCTGATATGACG	0.318													13	17					1.3612e-06	1.46279e-06	1	0	A	59742026	A	A	59742026	3	1	264	1	0	0	0	0	1	0	0	0	11948	913	32	2	202	2	PIGN	18	59742026	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	11964870	59742026	18335222	151	48221											
BTBD2	55643	broad.mit.edu	37	chr19	1993106	1993106	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcgagcgctggcaccgcgtaCttcttggcggtgtatagcgt	5	11	14	11	6	1	0	0	0	1	0	2	1	1	0	1	3	3	4	1	3	3	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:1993106C>T	uc002lup.1	-	3	597	c.597G>A	c.(595-597)AAG>AAA	p.K199K	BTBD2_uc002luo.1_5'Flank	NM_017797	NP_060267	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	199						cytoplasmic mRNA processing body	protein binding			ovary(1)|skin(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACCGCGTACTTCTTGGCGG	0.632													5	24					0	0	0	0	T	1993106	T	T	1993106	2	4	264	1	0	0	0	0	0	0	0	1	1548	564	20	4		4	BTBD2	19	1993106	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08		1993106	57135877	152	48222											
PLIN5	440503	broad.mit.edu	37	chr19	4523797	4523797	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgctccacaaggatgggcgCgaagggtcccaccagccagg	9	4	14	14	3	0	0	0	0	0	0	3	2	2	1	4	4	1	1	4	4	2	0			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:4523797C>G	uc002mas.2	-	8	1188	c.1135G>C	c.(1135-1137)GCG>CCG	p.A379P		NM_001013706	NP_001013728	Q00G26	PLIN5_HUMAN	lipid storage droplet protein 5	379						lipid particle					0						AGGATGGGCGCGAAGGGTCCC	0.751													12	25					0	0	0	0	G	4523797	G	G	4523797	3	3	264	1	0	0	0	0	1	0	0	0	12148	768	27	3	260	3	PLIN5	19	4523797	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	2530691	4523797	54605186	153	48223											
ZNF700	90592	broad.mit.edu	37	chr19	12060067	12060067	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttcctttcgatatcatgaaAggattcacactggagagaaa	14	11	9	7	1	2	2	2	1	0	1	4	6	3	4	1	2	0	1	1	2	3	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:12060067A>G	uc002msu.2	+	4	1354	c.1228A>G	c.(1228-1230)AGG>GGG	p.R410G	ZNF700_uc010xme.1_Missense_Mutation_p.R428G|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	410	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATATCATGAAAGGATTCACAC	0.443													22	62					0	0	0	0	G	12060067	G	G	12060067	3	3	264	1	0	0	0	0	1	0	0	0	18171	63	3	5	1242	5	ZNF700	19	12060067	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	7536270	12060067	47068916	154	48224											
ZNF709	163051	broad.mit.edu	37	chr19	12575299	12575299	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctaaaggctttaccacactgTttacattcatagggtttctc	10	15	6	10	0	2	0	1	0	1	0	3	0	2	0	1	2	2	3	1	2	5	8			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:12575299T>C	uc002mtv.3	-	4	1598	c.1437A>G	c.(1435-1437)AAA>AAG	p.K479K	ZNF709_uc002mtw.3_Silent_p.K447K|ZNF709_uc002mtx.3_Silent_p.K479K	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	479	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACCACACTGTTTACATTCAT	0.398													42	102					0	0	0	0	C	12575299	C	C	12575299	2	2	264	1	0	0	0	0	0	0	0	1	18180	1722	60	5		5	ZNF709	19	12575299	Silent	SNP	T	TCGA-CV-7432-01A-11D-2129-08	515232	12575299	46553684	155	48225											
MAP1S	55201	broad.mit.edu	37	chr19	17844128	17844128	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagttcttccagcgcgtgcGcgcgctctgctacgtcatca	5	10	12	14	6	4	0	2	0	2	0	5	1	5	1	1	1	4	3	1	1	1	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:17844128G>T	uc002nhe.1	+	6	2924	c.2915G>T	c.(2914-2916)CGC>CTC	p.R972L	MAP1S_uc010eba.1_Intron|MAP1S_uc002nhf.1_Missense_Mutation_p.R220L|MAP1S_uc010xpv.1_Missense_Mutation_p.R946L	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	972	Necessary for association with actin (By similarity).|Necessary for interaction with RASSF1 isoform A and isoform C.|Necessary for the mitochondrial aggregation and genome destruction.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						CAGCGCGTGCGCGCGCTCTGC	0.672													8	12					0.00448238	0.00452427	1	0	T	17844128	T	T	17844128	3	4	264	1	0	0	0	0	1	0	0	0	9287	1087	38	3	2937	3	MAP1S	19	17844128	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	5268829	17844128	41284855	156	48226											
ZNF626	199777	broad.mit.edu	37	chr19	20807449	20807449	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattttcttatgtgtagtaaGgttagaggagtacttaaaag	14	15	10	2	0	1	1	0	0	1	1	1	2	1	2	0	2	1	4	0	2	8	8			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:20807449G>T	uc002npb.1	-	4	1384	c.1234C>A	c.(1234-1236)CTT>ATT	p.L412I	ZNF626_uc002npc.1_Missense_Mutation_p.L336I	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	412	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TGTGTAGTAAGGTTAGAGGAG	0.403													16	49					3.41278e-10	3.83938e-10	1	0	T	20807449	T	T	20807449	3	4	264	1	0	0	0	0	1	0	0	0	18117	1000	35	4	356	4	ZNF626	19	20807449	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	2963321	20807449	38321534	157	48227											
MIA	8190	broad.mit.edu	37	chr19	41281724	41281724	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgccgattcctgaccattcaCcggggccaagtggtgtatgt	7	11	12	11	2	1	1	1	1	0	0	2	2	2	1	5	3	1	1	5	3	2	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:41281724C>T	uc002opb.3	+	2	343	c.195C>T	c.(193-195)CAC>CAT	p.H65H	MIA_uc010xvt.1_RNA|RAB4B_uc002opc.1_RNA|RAB4B_uc002opd.1_5'Flank|RAB4B_uc002ope.1_5'Flank|EGLN2_uc010ehd.2_5'Flank	NM_006533	NP_006524	Q16674	MIA_HUMAN	melanoma inhibitory activity precursor	65	SH3.				cell proliferation	extracellular space	growth factor activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)	GBM - Glioblastoma multiforme(1328;0.0199)		TGACCATTCACCGGGGCCAAG	0.587													33	62					0	0	0	0	T	41281724	T	T	41281724	2	4	264	1	0	0	0	0	0	0	0	1	9616	506	18	4		4	MIA	19	41281724	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	20474275	41281724	17847259	158	48228											
PTOV1	53635	broad.mit.edu	37	chr19	50361873	50361873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcaccaaggacctggagaCactgaagagcctgtgccgga	11	6	12	12	1	1	3	1	1	0	2	1	6	1	5	4	3	2	0	4	3	2	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:50361873C>T	uc002pqf.1	+	10	1174	c.1004C>T	c.(1003-1005)ACA>ATA	p.T335I	PTOV1_uc002ppz.3_RNA|PTOV1_uc002pqb.3_Missense_Mutation_p.T303I|PTOV1_uc002pqa.2_RNA|PTOV1_uc002pqc.1_RNA|PTOV1_uc002pqd.2_RNA|PTOV1_uc002pqe.1_RNA	NM_017432	NP_059128	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	335	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		GACCTGGAGACACTGAAGAGC	0.667													4	9					0	0	0	0	T	50361873	T	T	50361873	3	4	264	1	0	0	0	0	1	0	0	0	12832	478	17	4	1042	4	PTOV1	19	50361873	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	9080149	50361873	8767110	159	48229											
ZNF845	91664	broad.mit.edu	37	chr19	53855800	53855800	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcgttcataccttgcagtTcattggcgaactcatagtgg	9	13	9	10	2	3	0	3	0	0	0	4	1	3	0	1	2	3	3	1	2	3	6			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:53855800T>C	uc010ydv.1	+	4	1989	c.1872T>C	c.(1870-1872)GTT>GTC	p.V624V	ZNF845_uc010ydw.1_Silent_p.V624V	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	624	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACCTTGCAGTTCATTGGCGAA	0.363													2	11					0	0	0	0	C	53855800	C	C	53855800	2	2	264	1	0	0	0	0	0	0	0	1	18258	1770	62	5		5	ZNF845	19	53855800	Silent	SNP	T	TCGA-CV-7432-01A-11D-2129-08	3493927	53855800	5273183	160	48230											
CACNG8	59283	broad.mit.edu	37	chr19	54466453	54466453	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctggtgcgagaagggggtGcaggtgctgctgacgacggt	6	8	19	8	3	1	2	0	1	1	1	1	4	1	2	0	5	4	3	0	5	1	0			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	a0228446-5e7f-437e-b15e-b7a022572d9d	g.chr19:54466453G>A	uc002qcs.1	+	1	160	c.54G>A	c.(52-54)GTG>GTA	p.V18V		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	19	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		AGAAGGGGGTGCAGGTGCTGC	0.682													6	13					0	0	0	0	A	54466453	A	A	54466453	2	1	264	1	0	0	0	0	0	0	0	1	2575	1306	46	4		4	CACNG8	19	54466453	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	610653	54466453	4662530	161	48231											
LILRA2	11027	broad.mit.edu	37	chr19	55086773	55086773	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agccaggtcctatggtggccCccggggagagcctgaccctc	6	6	14	15	1	0	2	0	1	0	1	2	3	1	2	6	5	2	0	6	5	1	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:55086773C>T	uc002qgg.3	+	5	795	c.706C>T	c.(706-708)CCC>TCC	p.P236S	LILRA2_uc010ern.2_Missense_Mutation_p.P236S|LILRA2_uc002qgf.2_Missense_Mutation_p.P236S|LILRA2_uc010yfe.1_Missense_Mutation_p.P236S|LILRA2_uc010yff.1_Missense_Mutation_p.P224S|LILRA2_uc010ero.2_Missense_Mutation_p.P224S|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	236	Ig-like C2-type 3.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		TATGGTGGCCCCCGGGGAGAG	0.567													47	83					0	0	0	0	T	55086773	T	T	55086773	3	4	264	1	0	0	0	0	1	0	0	0	8826	623	22	4	724	4	LILRA2	19	55086773	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	620320	55086773	4042210	162	48232											
NLRP7	199713	broad.mit.edu	37	chr19	55450643	55450643	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagtgtcctacttgaatcAggtcggggttcttgagtctt	8	14	12	7	1	3	3	1	2	2	1	5	3	4	3	1	3	1	1	1	3	3	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:55450643A>T	uc002qih.3	-	4	1620	c.1544T>A	c.(1543-1545)CTG>CAG	p.L515Q	NLRP7_uc002qig.3_Missense_Mutation_p.L515Q|NLRP7_uc002qii.3_Missense_Mutation_p.L515Q|NLRP7_uc010esk.2_Missense_Mutation_p.L515Q|NLRP7_uc010esl.2_Missense_Mutation_p.L543Q	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	515							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TACTTGAATCAGGTCGGGGTT	0.567													28	66					0	0	0	0	T	55450643	T	T	55450643	3	4	264	1	0	0	0	0	1	0	0	0	10536	188	7	5	1601	5	NLRP7	19	55450643	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	363870	55450643	3678340	163	48233											
NLRP4	147945	broad.mit.edu	37	chr19	56370318	56370318	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aaaactggatgcgttttttgGcttccaactgtcccaagaga	11	12	9	9	1	0	1	0	0	0	1	2	3	2	2	2	2	3	2	2	2	4	4			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr19:56370318G>T	uc002qmd.3	+	3	1981	c.1559G>T	c.(1558-1560)GGC>GTC	p.G520V	NLRP4_uc002qmf.2_Missense_Mutation_p.G445V|NLRP4_uc010etf.2_Missense_Mutation_p.G351V	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	520							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GCGTTTTTTGGCTTCCAACTG	0.428													24	61					1.55469e-16	1.84513e-16	1	0	T	56370318	T	T	56370318	3	4	264	1	0	0	0	0	1	0	0	0	10533	1203	42	4	1565	4	NLRP4	19	56370318	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	919675	56370318	2758665	164	48234											
TMC2	117532	broad.mit.edu	37	chr20	2517943	2517943	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagtgaaagggcgggtgaaGagcggctctccacacacagg	11	4	17	9	2	1	3	0	2	1	1	2	4	1	4	1	5	1	1	1	5	2	0			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	a0228446-5e7f-437e-b15e-b7a022572d9d	g.chr20:2517943G>A	uc002wgf.1	+	2	78	c.63G>A	c.(61-63)AAG>AAA	p.K21K	TMC2_uc002wgg.1_Intron	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	21	Arg/Asp/Glu/Lys-rich (highly charged).|Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GGCGGGTGAAGAGCGGCTCTC	0.632													6	14					0	0	0	0	A	2517943	A	A	2517943	2	1	264	1	0	0	0	0	0	0	0	1	16051	933	33	2		2	TMC2	20	2517943	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08		2517943	60507577	165	48235											
SIGLEC1	6614	broad.mit.edu	37	chr20	3684491	3684491	+	Frame_Shift_Del	DEL	G	-	-																															ctgaagatgtggaggctgatGgggggtgagaccaaagagcc																										TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr20:3684491delG	uc002wja.2	-	4	954	c.954delC	c.(952-954)CCCfs	p.P318fs	SIGLEC1_uc002wiz.3_Frame_Shift_Del_p.P318fs|SIGLEC1_uc002wjc.2_Frame_Shift_Del_p.P229fs	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	318	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GGAGGCTGATGGGGGGTGAGA	0.617													---	---	---								-	3684491	-	-	3684491	7	5	264	1	0	1	0	1	0	0	0	0	14370	1335	47	0	4247	0	SIGLEC1	20	3684491	Frame_Shift_Del	DEL	G	TCGA-CV-7432-01A-11D-2129-08	1166548	3684491	59341029	166	48236											
SNRPB2	6629	broad.mit.edu	37	chr20	16712386	16712386	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catacaatttatatcaacaaTatgaatgacaaaattaaaaa	23	11	2	5	0	1	2	1	2	0	0	1	2	1	2	0	0	2	0	0	0	13	6			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr20:16712386T>C	uc002wph.1	+	2	255	c.39T>C	c.(37-39)AAT>AAC	p.N13N	SNRPB2_uc002wpi.1_Silent_p.N13N	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''	13	RRM 1.					catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						ATATCAACAATATGAATGACA	0.274													39	102					0	0	0	0	C	16712386	C	C	16712386	2	2	264	1	0	0	0	0	0	0	0	1	14926	1403	49	5		5	SNRPB2	20	16712386	Silent	SNP	T	TCGA-CV-7432-01A-11D-2129-08	13027895	16712386	46313134	167	48237											
CST11	140880	broad.mit.edu	37	chr20	23433318	23433318	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccactgcaagctgtccttcGcatagttttctactgccatc	7	14	6	14	1	1	0	0	0	1	0	5	0	3	0	3	0	4	4	3	0	3	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr20:23433318G>A	uc002wtf.1	-	1	165	c.131C>T	c.(130-132)GCG>GTG	p.A44V	CST11_uc002wtg.1_Missense_Mutation_p.A44V	NM_130794	NP_570612	Q9H112	CST11_HUMAN	cystatin 11 isoform 1 precursor	44					defense response to bacterium	cytoplasm|nucleus	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					GCTGTCCTTCGCATAGTTTTC	0.483													45	113					0	0	0	0	A	23433318	A	A	23433318	3	1	264	1	0	0	0	0	1	0	0	0	3988	1087	38	1	297	1	CST11	20	23433318	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	6720932	23433318	39592202	168	48238											
CST5	1473	broad.mit.edu	37	chr20	23860167	23860167	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtactcgctgatggcaaaGtccagggcacactgcacact	10	9	10	12	1	0	1	0	1	0	0	2	1	1	1	1	2	2	5	1	2	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr20:23860167G>A	uc002wtr.1	-	1	214	c.147C>T	c.(145-147)GAC>GAT	p.D49D		NM_001900	NP_001891	P28325	CYTD_HUMAN	cystatin D precursor	49						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding				0						TGATGGCAAAGTCCAGGGCAC	0.577													59	130					0	0	0	0	A	23860167	A	A	23860167	2	1	264	1	0	0	0	0	0	0	0	1	3992	1020	36	4		4	CST5	20	23860167	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	426849	23860167	39165353	169	48239											
MYLK2	85366	broad.mit.edu	37	chr20	30414610	30414610	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgcacacagcatcgagggcGgagagctcttcgagaggatt	10	7	15	9	3	1	2	0	0	1	2	3	6	1	3	0	3	3	3	0	3	0	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr20:30414610G>A	uc002wwq.2	+	8	1195	c.1093G>A	c.(1093-1095)GGA>AGA	p.G365R	MYLK2_uc002wws.2_5'UTR	NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	365	Protein kinase.				cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CATCGAGGGCGGAGAGCTCTT	0.587													9	25					0	0	0	0	A	30414610	A	A	30414610	3	1	264	1	0	0	0	0	1	0	0	0	10110	1117	39	1	1119	1	MYLK2	20	30414610	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	6554443	30414610	32610910	170	48240											
ASXL1	171023	broad.mit.edu	37	chr20	31021634	31021634	+	Frame_Shift_Del	DEL	C	-	-																															agaagccccggcttgaagatCgtcagtcctttcgtaacaca																								rs137920574	byFrequency	TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr20:31021634delC	uc002wxs.2	+	11	2059	c.1633delC	c.(1633-1635)CGTfs	p.R545fs	ASXL1_uc010geb.2_Frame_Shift_Del_p.R436fs	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	545					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GCTTGAAGATCGTCAGTCCTT	0.517			F|N|Mis		MDS|CMML								---	---	---								-	31021634	-	-	31021634	7	5	264	1	0	1	0	1	0	0	0	0	1068	884	31	0	1685	0	ASXL1	20	31021634	Frame_Shift_Del	DEL	C	TCGA-CV-7432-01A-11D-2129-08	607024	31021634	32003886	171	48241											
PTGIS	5740	broad.mit.edu	37	chr20	48124503	48124503	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacgtcgtgttccggctgcAtcagaccgaagccgtacctg	7	8	12	14	5	1	1	1	0	0	1	3	2	2	1	4	1	3	5	4	1	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr20:48124503A>G	uc002xut.2	-	10	1511	c.1457T>C	c.(1456-1458)ATG>ACG	p.M486T	PTGIS_uc010zyi.1_Missense_Mutation_p.M347T	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	486					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	TTCCGGCTGCATCAGACCGAA	0.527													15	36					0	0	0	0	G	48124503	G	G	48124503	3	3	264	1	0	0	0	0	1	0	0	0	12815	217	8	5	49	5	PTGIS	20	48124503	Missense_Mutation	SNP	A	TCGA-CV-7432-01A-11D-2129-08	17102869	48124503	14901017	172	48242											
LAMA5	3911	broad.mit.edu	37	chr20	60893707	60893707	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgcacccgggccagcaCtagccgagaccagggtgagg	8	4	14	15	2	0	2	0	1	0	1	1	3	1	2	5	3	3	2	5	3	1	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr20:60893707C>A	uc002ycq.2	-	53	7110	c.7043_splice	c.e53-1	p.L2348_splice		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor						angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGGCCAGCACTAGCCGAGAC	0.677													18	23					5.3912e-06	5.70833e-06	1	0	A	60893707	A	A	60893707	5	1	264	1	0	0	0	0	0	0	1	0	8649	579	20	4	4157	4	LAMA5	20	60893707	Splice_Site	SNP	C	TCGA-CV-7432-01A-11D-2129-08	12769204	60893707	2131813	173	48243											
BTG3	10950	broad.mit.edu	37	chr21	18971032	18971032	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaggatcctgaatgataaTcagaggtaaccttatcaagg	16	9	10	6	0	2	4	2	2	0	2	3	5	3	5	2	3	1	1	2	3	6	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr21:18971032T>A	uc002ykk.2	-	4	682	c.422A>T	c.(421-423)GAT>GTT	p.D141V	BTG3_uc002ykl.2_Missense_Mutation_p.D185V	NM_006806	NP_006797	Q14201	BTG3_HUMAN	B-cell translocation gene 3 isoform b	141					negative regulation of cell proliferation|negative regulation of mitotic cell cycle	cytoplasm					0				Epithelial(23;0.000283)|all cancers(11;0.0012)|Lung(58;0.0191)|OV - Ovarian serous cystadenocarcinoma(11;0.0206)|COAD - Colon adenocarcinoma(22;0.0315)|LUSC - Lung squamous cell carcinoma(23;0.0703)|Colorectal(24;0.0971)		TGAATGATAATCAGAGGTAAC	0.423													12	25					0	0	0	0	A	18971032	A	A	18971032	3	1	264	1	0	0	0	0	1	0	0	0	1560	1435	50	5	344	5	BTG3	21	18971032	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08		18971032	29158863	174	48244											
KRTAP13-2	337959	broad.mit.edu	37	chr21	31744360	31744360	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgggctcccagcagatctCctgacagcccctatagagag	9	7	12	13	0	1	3	0	1	1	2	3	4	2	3	4	2	2	2	4	2	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr21:31744360C>A	uc002ynz.3	-	1	198	c.172G>T	c.(172-174)GAG>TAG	p.E58*		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	58	5 X 10 AA approximate repeats.|2.					intermediate filament					0						CAGCAGATCTCCTGACAGCCC	0.612													12	53					0.000978159	0.000996615	1	0	A	31744360	A	A	31744360	4	1	264	1	0	0	0	0	0	1	0	0	8562	864	30	2	359	2	KRTAP13-2	21	31744360	Nonsense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	12773328	31744360	16385535	175	48245											
GGTLC2	91227	broad.mit.edu	37	chr22	22988902	22988902	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctactacaagcccgagttCtacacgccggttgatggggg	8	9	12	12	3	1	1	0	1	1	0	2	2	2	1	3	3	4	2	3	3	4	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr22:22988902C>G	uc010gtt.2	+	1	121	c.87C>G	c.(85-87)TTC>TTG	p.F29L	LOC96610_uc011aim.1_Intron|POM121L1P_uc011ait.1_5'Flank|GGTLC2_uc010gts.2_Missense_Mutation_p.F29L	NM_199127	NP_954578	Q14390	GGTL2_HUMAN	gamma-glutamyltransferase-like 4 isoform 1	29					glutathione biosynthetic process		gamma-glutamyltransferase activity			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		AGCCCGAGTTCTACACGCCGG	0.607													13	15					0	0	0	0	G	22988902	G	G	22988902	3	3	264	1	0	0	0	0	1	0	0	0	6403	912	32	2	89	2	GGTLC2	22	22988902	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08		22988902	28315664	176	48246											
ASPHD2	57168	broad.mit.edu	37	chr22	26830196	26830196	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgtgagtttgagaccctCtacaaagctttctcaaactg	10	13	8	10	0	2	2	1	2	2	1	3	3	2	2	1	0	3	2	1	0	3	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr22:26830196C>T	uc003acg.2	+	2	1012	c.615C>T	c.(613-615)CTC>CTT	p.L205L		NM_020437	NP_065170	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	205	Lumenal (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			ovary(1)	1						TTGAGACCCTCTACAAAGCTT	0.532													22	28					0	0	0	0	T	26830196	T	T	26830196	2	4	264	1	0	0	0	0	0	0	0	1	1057	900	32	2		2	ASPHD2	22	26830196	Silent	SNP	C	TCGA-CV-7432-01A-11D-2129-08	3841294	26830196	24474370	177	48247											
CACNA1I	8911	broad.mit.edu	37	chr22	40073401	40073401	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttcatctatgctgctctcgGggtggagctctttgggaagc	5	13	13	10	1	4	0	1	0	3	0	5	2	4	2	0	4	4	3	0	4	2	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chr22:40073401G>T	uc003ayc.2	+	30	4910	c.4910G>T	c.(4909-4911)GGG>GTG	p.G1637V	CACNA1I_uc003ayd.2_Missense_Mutation_p.G1602V|CACNA1I_uc003aye.2_Missense_Mutation_p.G1552V|CACNA1I_uc003ayf.2_Missense_Mutation_p.G1517V	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1637	Helical; Name=S5 of repeat IV; (Potential).|IV.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GCTGCTCTCGGGGTGGAGCTC	0.682													3	6					0.000602214	0.000619421	1	0	T	40073401	T	T	40073401	3	4	264	1	0	0	0	0	1	0	0	0	2558	1232	43	4	5028	4	CACNA1I	22	40073401	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	13243205	40073401	11231165	178	48248											
MXRA5	25878	broad.mit.edu	37	chrX	3238516	3238516	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaactgtggaaaagaaagaGtcttgttggtaaagaaaggg	16	8	13	4	0	1	3	0	0	1	3	1	4	1	4	1	3	1	2	1	3	7	3			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chrX:3238516G>A	uc004crg.3	-	5	5367	c.5210C>T	c.(5209-5211)ACT>ATT	p.T1737I		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1737						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAAAGAAAGAGTCTTGTTGGT	0.463													4	10					0	0	0	0	A	3238516	A	A	3238516	3	1	264	1	0	0	0	0	1	0	0	0	10056	1029	36	4	3288	4	MXRA5	23	3238516	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08		3238516	152032044	179	48249											
CDKL5	6792	broad.mit.edu	37	chrX	18606257	18606257	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agtaatcctcgcttccatggGctccgggtaagaggttttgc	7	12	12	10	2	0	1	0	0	0	1	4	1	3	1	3	3	1	5	3	3	2	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chrX:18606257G>T	uc004cym.2	+	9	991	c.738G>T	c.(736-738)GGG>GGT	p.G246G	CDKL5_uc004cyn.2_Silent_p.G246G	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	246	Protein kinase.				neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					GCTTCCATGGGCTCCGGGTAA	0.403													44	55					2.68985e-26	3.24585e-26	1	0	T	18606257	T	T	18606257	2	4	264	1	0	0	0	0	0	0	0	1	3172	1190	42	4		4	CDKL5	23	18606257	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	15367741	18606257	136664303	180	48250											
FAM47C	442444	broad.mit.edu	37	chrX	37028110	37028111	+	Frame_Shift_Ins	INS	-	TA	TA																															ggcacctcctgagagtagcgINStatctcatctccgcccagag																								rs143115052	byFrequency	TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chrX:37028110_37028111insTA	uc004ddl.1	+	1	1641_1642	c.1627_1628insTA	c.(1627-1629)GTAfs	p.V543fs		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	543										ovary(3)	3						TGAGAGTAGCGTATCTCATCTC	0.619													---	---	---								TA	37028111	TA	TA	37028110	7	5	264	1	0	1	1	0	0	0	0	0	5603	1145	40	0	1629	0	FAM47C	23	37028110	Frame_Shift_Ins	INS	-	TCGA-CV-7432-01A-11D-2129-08	18421853	37028110	118242450	181	48251											
FAM47C	442444	broad.mit.edu	37	chrX	37028185	37028185	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agcctcccaagactcggatgTacagtctccgcccggagcct	8	7	10	16	3	1	1	0	0	1	1	4	3	2	3	5	2	3	1	5	2	2	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chrX:37028185T>C	uc004ddl.1	+	1	1716	c.1702T>C	c.(1702-1704)TAC>CAC	p.Y568H		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	568										ovary(3)	3						GACTCGGATGTACAGTCTCCG	0.647													25	33					0	0	0	0	C	37028185	C	C	37028185	3	2	264	1	0	0	0	0	1	0	0	0	5603	1638	57	5	1704	5	FAM47C	23	37028185	Missense_Mutation	SNP	T	TCGA-CV-7432-01A-11D-2129-08	75	37028185	118242375	182	48252											
TBC1D25	4943	broad.mit.edu	37	chrX	48419318	48419318	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgattacctgcagtcagaGgtgtgggactcagaggaggg	9	8	17	7	0	2	3	2	1	0	2	2	5	2	5	1	4	2	2	1	4	1	1			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chrX:48419318G>A	uc004dka.1	+	6	2133	c.2022G>A	c.(2020-2022)GAG>GAA	p.E674E	TBC1D25_uc011mly.1_Silent_p.E616E|TBC1D25_uc004dkb.1_Silent_p.E420E|TBC1D25_uc011mlz.1_Silent_p.E420E|TBC1D25_uc011mma.1_Silent_p.E420E|TBC1D25_uc004dkc.1_Silent_p.E420E|TBC1D25_uc011mmb.1_Silent_p.E678E|TBC1D25_uc011mmc.1_Silent_p.E420E|TBC1D25_uc011mmd.1_Silent_p.E420E	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	674						intracellular	Rab GTPase activator activity			ovary(1)	1						TGCAGTCAGAGGTGTGGGACT	0.597													14	8					0	0	0	0	A	48419318	A	A	48419318	2	1	264	1	0	0	0	0	0	0	0	1	15681	991	35	4		4	TBC1D25	23	48419318	Silent	SNP	G	TCGA-CV-7432-01A-11D-2129-08	11391133	48419318	106851242	183	48253											
GNL3L	54552	broad.mit.edu	37	chrX	54569430	54569430	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atatgtttcctcagctggatGacgaggccacgaggaaggct	10	9	13	9	2	1	1	1	1	0	0	2	5	2	3	2	4	1	3	2	4	2	2			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chrX:54569430G>A	uc004dth.1	+	6	488	c.349G>A	c.(349-351)GAC>AAC	p.D117N	GNL3L_uc004dti.2_RNA	NM_019067	NP_061940	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3	117					ribosome biogenesis	nucleolus	GTP binding			ovary(1)	1						TCAGCTGGATGACGAGGCCAC	0.488													10	11					0	0	0	0	A	54569430	A	A	54569430	3	1	264	1	0	0	0	0	1	0	0	0	6575	1290	45	2	367	2	GNL3L	23	54569430	Missense_Mutation	SNP	G	TCGA-CV-7432-01A-11D-2129-08	6150112	54569430	100701130	184	48254											
MCF2	4168	broad.mit.edu	37	chrX	138687074	138687074	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catgtttccaaagagaatgtCctttttatttctcaggagag	11	15	8	7	0	1	2	1	0	1	2	4	4	3	2	2	1	0	1	2	1	3	5			TCGA-CV-7432-01A-11D-2129-08	TCGA-CV-7432-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	60da7e3f-4d9c-4cb3-856d-6cc02e381028	8bc27f43-8ac4-4406-bf34-c595c8d07563	g.chrX:138687074C>A	uc004fau.2	-	14	1921	c.1627G>T	c.(1627-1629)GAC>TAC	p.D543Y	MCF2_uc004fav.2_Missense_Mutation_p.D559Y|MCF2_uc011mwl.1_Missense_Mutation_p.D520Y|MCF2_uc010nsh.1_Missense_Mutation_p.D543Y|MCF2_uc011mwm.1_Missense_Mutation_p.D504Y|MCF2_uc011mwn.1_Missense_Mutation_p.D688Y|MCF2_uc004faw.2_Missense_Mutation_p.D603Y|MCF2_uc011mwo.1_Missense_Mutation_p.D619Y	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	543	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					AAGAGAATGTCCTTTTTATTT	0.308													54	58					1.27102e-15	1.484e-15	1	0	A	138687074	A	A	138687074	3	1	264	1	0	0	0	0	1	0	0	0	9431	855	30	2	1226	2	MCF2	23	138687074	Missense_Mutation	SNP	C	TCGA-CV-7432-01A-11D-2129-08	84117644	138687074	16583486	185	48255											
TAS1R1	80835	broad.mit.edu	37	chr1	6639390	6639390	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttgccagagaactacaacGaggccaaatgtgtcaccttc	13	8	8	12	1	1	1	1	0	0	1	2	3	1	1	3	1	4	0	3	1	4	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:6639390G>A	uc001ant.2	+	6	2272	c.2272G>A	c.(2272-2274)GAG>AAG	p.E758K	TAS1R1_uc001anu.2_Missense_Mutation_p.E504K|TAS1R1_uc001anv.2_Silent_p.T289T|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	758	Cytoplasmic (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		GAACTACAACGAGGCCAAATG	0.572													24	42					0	0	0	0	A	6639390	A	A	6639390	3	1	265	1	0	0	0	0	1	0	0	0	15628	1059	37	1	2294	1	TAS1R1	1	6639390	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08		6639390	242611231	1	48256											
SPEN	23013	broad.mit.edu	37	chr1	16257103	16257103	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagctaaatccctctcttcAtctcgtgaagaaaattggtc	12	12	7	10	1	3	3	1	1	2	2	7	3	4	3	1	1	1	1	1	1	5	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:16257103A>G	uc001axk.1	+	11	4572	c.4368A>G	c.(4366-4368)TCA>TCG	p.S1456S	SPEN_uc010obp.1_Silent_p.S1415S	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1456					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCCTCTCTTCATCTCGTGAAG	0.368													11	93					0	0	0	0	G	16257103	G	G	16257103	2	3	265	1	0	0	0	0	0	0	0	1	15104	204	8	5		5	SPEN	1	16257103	Silent	SNP	A	TCGA-CV-7433-01A-11D-2129-08	9617713	16257103	232993518	2	48257											
IL12RB2	3595	broad.mit.edu	37	chr1	67787482	67787482	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaattctcaagtcacaggtCttccccttggtacaaccttg	9	13	6	13	0	4	0	3	0	2	0	6	0	5	0	3	2	2	1	3	2	4	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:67787482C>G	uc001ddu.2	+	3	914	c.274C>G	c.(274-276)CTT>GTT	p.L92V	IL12RB2_uc010oqi.1_Missense_Mutation_p.L92V|IL12RB2_uc010oqj.1_Missense_Mutation_p.L92V|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.L92V|IL12RB2_uc010oqm.1_Missense_Mutation_p.L92V|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	92	Extracellular (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						AGTCACAGGTCTTCCCCTTGG	0.423													16	150					0	0	0	0	G	67787482	G	G	67787482	3	3	265	1	0	0	0	0	1	0	0	0	7666	913	32	2	280	2	IL12RB2	1	67787482	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	51530379	67787482	181463139	3	48258											
RPAP2	79871	broad.mit.edu	37	chr1	92789160	92789160	+	Missense_Mutation	SNP	T	A	A																															agactttgtttcctccattcTaccaggaaacagaccaaatt																										TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:92789160T>A	uc001dot.2	+	8	792	c.683T>A	c.(682-684)CTA>CAA	p.L228Q	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	228						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		TCCTCCATTCTACCAGGAAAC	0.383													18	78					0	0	0	0	A	92789160	A	A	92789160	3	1	265	1	0	0	0	0	1	0	0	0	13607	1522	53	5	713	5	RPAP2	1	92789160	Missense_Mutation	SNP	T	TCGA-CV-7433-01A-11D-2129-08	25001678	92789160	156461461	4	48259	107	2									
RPAP2	79871	broad.mit.edu	37	chr1	92789163	92789163	+	Missense_Mutation	SNP	C	A	A																															ctttgtttcctccattctacCaggaaacagaccaaattcaa																										TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:92789163C>A	uc001dot.2	+	8	795	c.686C>A	c.(685-687)CCA>CAA	p.P229Q	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	229						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		TCCATTCTACCAGGAAACAGA	0.383													19	78					1.15919e-05	1.25381e-05	1	0	A	92789163	A	A	92789163	3	1	265	1	0	0	0	0	1	0	0	0	13607	594	21	4	716	4	RPAP2	1	92789163	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	3	92789163	156461458	5	48260	107	2									
SSR2	6746	broad.mit.edu	37	chr1	155989899	155989899	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggaagccaaaagcctggcTccttcctctgcttgagtgac	8	11	10	12	0	1	2	0	2	1	0	3	3	3	3	4	2	3	2	4	2	3	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:155989899T>A	uc001fmx.2	-	2	140	c.60A>T	c.(58-60)GGA>GGT	p.G20G	SSR2_uc001fmw.2_RNA|SSR2_uc001fmy.2_RNA|SSR2_uc010pgv.1_Silent_p.G39G|SSR2_uc010pgw.1_Silent_p.G39G	NM_003145	NP_003136	P43308	SSRB_HUMAN	signal sequence receptor, beta precursor	20	Lumenal (Potential).				cotranslational protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					AAAGCCTGGCTCCTTCCTCTG	0.468													18	48					0	0	0	0	A	155989899	A	A	155989899	2	1	265	1	0	0	0	0	0	0	0	1	15257	1538	54	5		5	SSR2	1	155989899	Silent	SNP	T	TCGA-CV-7433-01A-11D-2129-08	63200736	155989899	93260722	6	48261											
F11R	50848	broad.mit.edu	37	chr1	160990822	160990822	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacaggatcgccaatatgaaGaggcacaacagtttcctctc	14	8	8	11	1	1	2	0	1	1	1	4	3	2	3	2	2	2	2	2	2	5	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:160990822G>C	uc009wtt.2	-	1	312	c.42C>G	c.(40-42)CTC>CTG	p.L14L	F11R_uc010pjv.1_Silent_p.L14L|F11R_uc001fxe.3_Silent_p.L14L|F11R_uc009wtu.2_Silent_p.L14L|F11R_uc010pjw.1_Intron|F11R_uc001fxf.3_Silent_p.L14L	NM_016946	NP_058642	Q9Y624	JAM1_HUMAN	F11 receptor precursor	14					blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction		p.L14F(1)		ovary(2)	2	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			CCAATATGAAGAGGCACAACA	0.587													8	37					0	0	0	0	C	160990822	C	C	160990822	2	2	265	1	0	0	0	0	0	0	0	1	5363	929	33	2		2	F11R	1	160990822	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08	5000923	160990822	88259799	7	48262											
CFHR1	3078	broad.mit.edu	37	chr1	196796099	196796099	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acaacatttcatgtgtagaaCggggctggtccacccctccc	9	9	9	14	1	1	1	1	0	0	1	3	1	3	1	4	3	2	2	4	3	3	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:196796099C>A	uc001gtn.2	+	3	508	c.394C>A	c.(394-396)CGG>AGG	p.R132R	CFHR1_uc001gtm.2_Intron	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	132	Sushi 2.				complement activation	extracellular space					0						ATGTGTAGAACGGGGCTGGTC	0.393													24	57					1.85244e-09	2.18176e-09	1	0	A	196796099	A	A	196796099	2	1	265	1	0	0	0	0	0	0	0	1	3299	527	19	3		3	CFHR1	1	196796099	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	35805277	196796099	52454522	8	48263											
MOSC1	64757	broad.mit.edu	37	chr1	220986691	220986691	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggaaaatcaccactctttggGcagtattttgtgctggaaaa	12	12	10	7	0	2	0	1	0	1	0	2	2	2	2	1	3	1	3	1	3	5	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:220986691G>C	uc001hms.2	+	7	1193	c.945G>C	c.(943-945)GGG>GGC	p.G315G	MOSC1_uc001hmt.2_Silent_p.G332G	NM_022746	NP_073583	Q5VT66	MOSC1_HUMAN	MOCO sulphurase C-terminal domain containing 1	315	MOSC.						molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding				0				GBM - Glioblastoma multiforme(131;0.0358)		CACTCTTTGGGCAGTATTTTG	0.473													13	170					0	0	0	0	C	220986691	C	C	220986691	2	2	265	1	0	0	0	0	0	0	0	1	9766	1190	42	4		4	MOSC1	1	220986691	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08	24190592	220986691	28263930	9	48264											
C1orf101	257044	broad.mit.edu	37	chr1	244681992	244681992	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattcttcaaatgagaaaatGagaagggggtatttaatttt	15	15	9	2	0	2	2	1	2	1	2	2	4	2	2	0	2	0	1	0	2	7	8			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:244681992G>C	uc001iam.2	+	8	587	c.528G>C	c.(526-528)ATG>ATC	p.M176I	C1orf101_uc001iak.1_Intron|C1orf101_uc001ial.2_Missense_Mutation_p.M176I|C1orf101_uc010pym.1_Missense_Mutation_p.M25I|C1orf101_uc010pyn.1_Intron	NM_001130957	NP_001124429	Q5SY80	CA101_HUMAN	hypothetical protein LOC257044 isoform 1	176	Extracellular (Potential).					integral to membrane				ovary(1)|breast(1)	2	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			ATGAGAAAATGAGAAGGGGGt	0.299													9	54					0	0	0	0	C	244681992	C	C	244681992	3	2	265	1	0	0	0	0	1	0	0	0	1985	1290	45	2	558	2	C1orf101	1	244681992	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	23695301	244681992	4568629	10	48265											
NLRP3	114548	broad.mit.edu	37	chr1	247588376	247588376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggaaaaggaaggaaggaCgaacgttccagggagtcgtt	15	5	16	5	3	0	1	0	0	0	1	2	7	1	6	1	5	1	2	1	5	5	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr1:247588376C>T	uc001icr.2	+	5	1769	c.1631C>T	c.(1630-1632)ACG>ATG	p.T544M	NLRP3_uc001ics.2_Missense_Mutation_p.T544M|NLRP3_uc001icu.2_Missense_Mutation_p.T544M|NLRP3_uc001icw.2_Missense_Mutation_p.T544M|NLRP3_uc001icv.2_Missense_Mutation_p.T544M|NLRP3_uc010pyw.1_Missense_Mutation_p.T542M|NLRP3_uc001ict.1_Missense_Mutation_p.T542M	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	544					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GAAGGAAGGACGAACGTTCCA	0.473													14	36					0	0	0	0	T	247588376	T	T	247588376	3	4	265	1	0	0	0	0	1	0	0	0	10532	536	19	1	1641	1	NLRP3	1	247588376	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	2906384	247588376	1662245	11	48266											
ID2	3398	broad.mit.edu	37	chr2	8822625	8822625	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaccctcaacacggatatCagcatcctgtccttgcaggt	10	9	7	15	1	2	0	2	0	0	0	4	1	4	1	4	2	3	2	4	2	2	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr2:8822625C>T	uc010yiu.1	+	3	825	c.330C>T	c.(328-330)ATC>ATT	p.I110I	ID2_uc002qza.2_Silent_p.I110I	NM_002166	NP_002157	Q02363	ID2_HUMAN	inhibitor of DNA binding 2	110	Nuclear export signal (By similarity).				cellular senescence|embryonic digestive tract morphogenesis|endodermal digestive tract morphogenesis|epithelial cell differentiation involved in mammary gland alveolus development|mammary gland epithelial cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of neuron differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|neuron fate commitment|positive regulation of blood pressure|positive regulation of cell cycle arrest|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent	protein complex	protein binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ACACGGATATCAGCATCCTGT	0.652													7	53					0	0	0	0	T	8822625	T	T	8822625	2	4	265	1	0	0	0	0	0	0	0	1	7529	816	29	2		2	ID2	2	8822625	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08		8822625	234376748	12	48267											
ROCK2	9475	broad.mit.edu	37	chr2	11341183	11341183	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttctctttttccaaatcaGaatattgttcttcagcaatt	10	19	3	9	0	5	1	2	0	3	1	7	1	6	1	1	0	1	2	1	0	4	8			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr2:11341183G>C	uc002rbd.1	-	23	3259	c.2810C>G	c.(2809-2811)TCT>TGT	p.S937C		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	937	Potential.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TTCCAAATCAGAATATTGTTC	0.413													13	155					0	0	0	0	C	11341183	C	C	11341183	3	2	265	1	0	0	0	0	1	0	0	0	13583	942	33	2	1400	2	ROCK2	2	11341183	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	2518558	11341183	231858190	13	48268											
CLIP4	79745	broad.mit.edu	37	chr2	29356553	29356553	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagctgtaaaatttgcaactCagcttattgacctgggagca	12	11	9	9	0	1	1	1	1	0	0	1	2	1	2	1	1	5	5	1	1	4	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr2:29356553C>G	uc002rmv.2	+	5	639	c.400C>G	c.(400-402)CAG>GAG	p.Q134E	CLIP4_uc002rmu.2_Missense_Mutation_p.Q134E|CLIP4_uc010ezm.1_Missense_Mutation_p.Q134E|CLIP4_uc002rmw.2_RNA|CLIP4_uc010ymn.1_Missense_Mutation_p.Q116E	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	134										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					ATTTGCAACTCAGCTTATTGA	0.368													11	46					0	0	0	0	G	29356553	G	G	29356553	3	3	265	1	0	0	0	0	1	0	0	0	3550	827	29	2	414	2	CLIP4	2	29356553	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	18015370	29356553	213842820	14	48269											
MSH6	2956	broad.mit.edu	37	chr2	48026701	48026714	+	Frame_Shift_Del	DEL	CTGGAAGGTGATCC	-	-																															gtacacagacttacagtgtgCtggaaggtgatccctctgag																								rs63751090		TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr2:48026701_48026714delCTGGAAGGTGATCC	uc002rwd.3	+	4	1731_1744	c.1579_1592delCTGGAAGGTGATCC	c.(1579-1593)CTGGAAGGTGATCCCfs	p.L527fs	MSH6_uc002rwc.2_Frame_Shift_Del_p.L527fs|MSH6_uc010fbj.2_Frame_Shift_Del_p.L225fs|MSH6_uc010yoi.1_Frame_Shift_Del_p.L397fs|MSH6_uc010yoj.1_Frame_Shift_Del_p.L225fs	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	527_531					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTACAGTGTGCTGGAAGGTGATCCCTCTGAGAAC	0.435			Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				---	---	---								-	48026714	-	-	48026701	7	5	265	1	0	1	0	1	0	0	0	0	9927	796	28	0	1593	0	MSH6	2	48026701	Frame_Shift_Del	DEL	CTGGAAGGTGATCC	TCGA-CV-7433-01A-11D-2129-08	18670148	48026701	195172672	15	48270											
RTN4	57142	broad.mit.edu	37	chr2	55252633	55252633	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caatgtagggaactcatctaTaatttcaattggagatgaat	15	13	8	5	0	3	2	2	1	1	1	3	4	3	3	0	2	1	1	0	2	7	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr2:55252633T>C	uc002rye.2	-	3	2900	c.2602A>G	c.(2602-2604)ATA>GTA	p.I868V	RTN4_uc002ryd.2_Missense_Mutation_p.I662V|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	868	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						AACTCATCTATAATTTCAATT	0.333													8	72					0	0	0	0	C	55252633	C	C	55252633	3	2	265	1	0	0	0	0	1	0	0	0	13793	1406	49	5	1042	5	RTN4	2	55252633	Missense_Mutation	SNP	T	TCGA-CV-7433-01A-11D-2129-08	7225932	55252633	187946740	16	48271											
ERCC3	2071	broad.mit.edu	37	chr2	128044304	128044304	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	atggtgtgcacttcatccagGatcatgaggccccactcctg	8	10	10	13	0	2	1	2	1	0	0	4	2	4	2	4	3	1	1	4	3	0	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr2:128044304G>C	uc002toh.1	-	8	1412	c.1317C>G	c.(1315-1317)ATC>ATG	p.I439M	ERCC3_uc002toe.1_Missense_Mutation_p.I194M|ERCC3_uc002tof.1_Missense_Mutation_p.I375M|ERCC3_uc002tog.1_Missense_Mutation_p.I375M|ERCC3_uc010flx.1_Missense_Mutation_p.I194M	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	439	Helicase ATP-binding.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CTTCATCCAGGATCATGAGGC	0.552			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				6	97					0	0	0	0	C	128044304	C	C	128044304	3	2	265	1	0	0	0	0	1	0	0	0	5238	1164	41	2	1063	2	ERCC3	2	128044304	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	72791671	128044304	115155069	17	48272											
STAM2	10254	broad.mit.edu	37	chr2	152989924	152989924	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagggaccctacctcatctaTataaacaggctcaggctctg	11	9	9	12	0	4	0	2	0	2	0	4	2	4	1	2	3	2	2	2	3	5	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr2:152989924T>C	uc002tyc.3	-	9	1224	c.874A>G	c.(874-876)ATA>GTA	p.I292V	STAM2_uc010foa.1_Missense_Mutation_p.I292V|STAM2_uc002tyd.2_Missense_Mutation_p.I292V	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	292					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		ACCTCATCTATATAAACAGGC	0.318													21	116					0	0	0	0	C	152989924	C	C	152989924	3	2	265	1	0	0	0	0	1	0	0	0	15315	1406	49	5	727	5	STAM2	2	152989924	Missense_Mutation	SNP	T	TCGA-CV-7433-01A-11D-2129-08	24945620	152989924	90209449	18	48273											
PKP4	8502	broad.mit.edu	37	chr2	159433849	159433849	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agattgttgccagtcagctaGaaagatgtaggcttggagca	12	10	13	6	0	1	3	1	0	0	3	1	4	1	4	1	2	3	5	1	2	3	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr2:159433849G>C	uc002tzv.2	+	3	459	c.199G>C	c.(199-201)GAA>CAA	p.E67Q	PKP4_uc002tzt.1_Intron|PKP4_uc002tzu.2_Missense_Mutation_p.E67Q|PKP4_uc002tzw.2_Missense_Mutation_p.E67Q|PKP4_uc002tzx.2_5'UTR|PKP4_uc002tzy.1_5'UTR|PKP4_uc002tzz.1_Missense_Mutation_p.E67Q|PKP4_uc002uaa.2_5'UTR	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	67	Potential.				cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						CAGTCAGCTAGAAAGATGTAG	0.478										HNSCC(62;0.18)			5	34					0	0	0	0	C	159433849	C	C	159433849	3	2	265	1	0	0	0	0	1	0	0	0	12042	943	33	2	205	2	PKP4	2	159433849	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	6443925	159433849	83765524	19	48274											
NFE2L2	4780	broad.mit.edu	37	chr2	178098965	178098965	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttactccaagatctataTcttgcctccaaagtatgtca	12	13	5	11	0	3	1	1	0	2	1	5	2	5	1	3	0	2	1	3	0	6	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr2:178098965T>C	uc002ulh.3	-	2	635	c.80A>G	c.(79-81)GAT>GGT	p.D27G	NFE2L2_uc002ulg.3_Missense_Mutation_p.D11G|NFE2L2_uc010zfa.1_Missense_Mutation_p.D11G|NFE2L2_uc002uli.3_Missense_Mutation_p.D11G|NFE2L2_uc010fra.2_Missense_Mutation_p.D11G|NFE2L2_uc010frb.2_Missense_Mutation_p.D11G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	27					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AAGATCTATATCTTGCCTCCA	0.353			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			5	32					0	0	0	0	C	178098965	C	C	178098965	3	2	265	1	0	0	0	0	1	0	0	0	10422	1435	50	5	1753	5	NFE2L2	2	178098965	Missense_Mutation	SNP	T	TCGA-CV-7433-01A-11D-2129-08	18665116	178098965	65100408	20	48275											
SATB2	23314	broad.mit.edu	37	chr2	200245204	200245204	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggcaagtcttccaacttTgaacaactgcaaaacagagc	15	7	8	11	0	1	2	0	1	1	1	2	2	2	2	1	1	6	3	1	1	6	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr2:200245204T>A	uc002uuy.1	-	5	1297	c.480A>T	c.(478-480)TCA>TCT	p.S160S	SATB2_uc010fsq.1_Intron|SATB2_uc002uuz.1_Silent_p.S160S|SATB2_uc002uva.1_Silent_p.S160S	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	160						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTCCAACTTTGAACAACTGC	0.483													7	56					0	0	0	0	A	200245204	A	A	200245204	2	1	265	1	0	0	0	0	0	0	0	1	13919	1799	63	5		5	SATB2	2	200245204	Silent	SNP	T	TCGA-CV-7433-01A-11D-2129-08	22146239	200245204	42954169	21	48276											
SLC22A14	9389	broad.mit.edu	37	chr3	38349184	38349184	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcatctcgcagtcagtggtgGgctacgccatcagcagcatt	8	9	12	12	2	3	0	2	0	1	0	4	0	3	0	1	2	3	5	1	2	1	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr3:38349184G>A	uc010hhc.1	+	4	790	c.748G>A	c.(748-750)GGC>AGC	p.G250S	SLC22A14_uc003cia.2_3'UTR|SLC22A14_uc003cib.2_Missense_Mutation_p.G250S|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	250	Helical; (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		GTCAGTGGTGGGCTACGCCAT	0.577													24	118					0	0	0	0	A	38349184	A	A	38349184	3	1	265	1	0	0	0	0	1	0	0	0	14510	1232	43	4	758	4	SLC22A14	3	38349184	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08		38349184	159673246	22	48277											
PFKFB4	5210	broad.mit.edu	37	chr3	48560992	48560992	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgccacaggagtcagcttCaggactgtgtgcagcggaca	10	8	13	10	1	2	0	2	0	0	0	2	3	2	3	1	3	4	2	1	3	1	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr3:48560992C>G	uc003ctv.2	-	12	1280	c.1263G>C	c.(1261-1263)CTG>CTC	p.L421L	PFKFB4_uc003ctw.2_Silent_p.L230L|PFKFB4_uc010hkc.2_Silent_p.L386L|PFKFB4_uc003ctx.2_Silent_p.L378L|PFKFB4_uc010hkb.2_Silent_p.L414L|PFKFB4_uc011bbm.1_Silent_p.L410L	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	421	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		GAGTCAGCTTCAGGACTGTGT	0.522													9	85					0	0	0	0	G	48560992	G	G	48560992	2	3	265	1	0	0	0	0	0	0	0	1	11818	813	29	2		2	PFKFB4	3	48560992	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	10211808	48560992	149461438	23	48278											
BOC	91653	broad.mit.edu	37	chr3	112987215	112987215	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gggaaacacagcagtcattgCctgccacctgcctgagagcc	10	6	11	14	0	1	1	1	1	0	1	1	3	1	2	5	1	6	1	5	1	1	1	rs139434929		TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr3:112987215C>T	uc003dzx.2	+	5	1067	c.446C>T	c.(445-447)GCC>GTC	p.A149V	BOC_uc010hqi.2_Missense_Mutation_p.A149V|BOC_uc003dzy.2_Missense_Mutation_p.A149V|BOC_uc003dzz.2_Missense_Mutation_p.A149V|BOC_uc003eab.2_5'Flank	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	149	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GCAGTCATTGCCTGCCACCTG	0.572													6	25					0	0	0	0	T	112987215	T	T	112987215	3	4	265	1	0	0	0	0	1	0	0	0	1484	739	26	4	456	4	BOC	3	112987215	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	64426223	112987215	85035215	24	48279											
MCM2	4171	broad.mit.edu	37	chr3	127339922	127339922	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttttcctgcagacttttGcccgctacctttcattccgg	4	17	6	14	2	1	1	1	0	0	1	3	1	3	1	4	1	3	2	4	1	1	8			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr3:127339922G>T	uc003ejp.2	+	15	2512	c.2455G>T	c.(2455-2457)GCC>TCC	p.A819S	MCM2_uc011bkm.1_Missense_Mutation_p.A689S|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Missense_Mutation_p.A772S	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	819					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						GCAGACTTTTGCCCGCTACCT	0.547													14	216					9.16793e-09	1.04121e-08	1	0	T	127339922	T	T	127339922	3	4	265	1	0	0	0	0	1	0	0	0	9439	1319	46	4	2513	4	MCM2	3	127339922	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	14352707	127339922	70682508	25	48280											
PLSCR4	57088	broad.mit.edu	37	chr3	145913005	145913005	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtcagcatctgccattgctGataacaaaccattccacttc	11	11	6	13	0	2	1	1	1	1	0	4	1	3	1	3	1	5	2	3	1	2	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr3:145913005G>A	uc010huy.2	-	8	1180	c.851C>T	c.(850-852)TCA>TTA	p.S284L	PLSCR4_uc010huz.2_Missense_Mutation_p.S284L|PLSCR4_uc003evt.3_Missense_Mutation_p.S284L|PLSCR4_uc010hva.2_Missense_Mutation_p.S194L|PLSCR4_uc003evu.3_Missense_Mutation_p.S179L	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	284	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						TGCCATTGCTGATAACAAACC	0.423													15	96					0	0	0	0	A	145913005	A	A	145913005	3	1	265	1	0	0	0	0	1	0	0	0	12167	1294	45	2	146	2	PLSCR4	3	145913005	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	18573083	145913005	52109425	26	48281											
SSR3	6747	broad.mit.edu	37	chr3	156272786	156272786	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaacgcgtttccgaagaaGagcgcggaggacttggccga	11	6	15	9	6	0	3	0	1	0	2	1	7	1	5	2	3	2	1	2	3	3	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr3:156272786G>C	uc003fau.2	-	1	150	c.93C>G	c.(91-93)CTC>CTG	p.L31L	SSR3_uc011bop.1_Silent_p.L31L	NM_007107	NP_009038	Q9UNL2	SSRG_HUMAN	signal sequence receptor gamma subunit	31	Helical; (Potential).				cotranslational protein targeting to membrane	integral to endoplasmic reticulum membrane|microsome|Sec61 translocon complex	protein binding|signal sequence binding				0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TTCCGAAGAAGAGCGCGGAGG	0.637													7	41					0	0	0	0	C	156272786	C	C	156272786	2	2	265	1	0	0	0	0	0	0	0	1	15258	929	33	2		2	SSR3	3	156272786	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08	10359781	156272786	41749644	27	48282											
FAM131A	131408	broad.mit.edu	37	chr3	184062544	184062547	+	Frame_Shift_Del	DEL	TGGG	-	-																															ggaaagtgccttccgcagccTgggcccactggaggcccagg																								rs145523198	byFrequency	TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr3:184062544_184062547delTGGG	uc003fog.2	+	3	2158_2161	c.794_797delTGGG	c.(793-798)CTGGGCfs	p.L265fs	FAM131A_uc003fob.1_Frame_Shift_Del_p.L173fs|FAM131A_uc003foc.2_Frame_Shift_Del_p.L211fs|FAM131A_uc003foe.2_Frame_Shift_Del_p.L211fs	NM_144635	NP_653236	Q6UXB0	F131A_HUMAN	hypothetical protein LOC131408 precursor	265_266						extracellular region				breast(1)	1	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCCGCAGCCTGGGCCCACTGGAG	0.691													---	---	---								-	184062547	-	-	184062544	7	5	265	1	0	1	0	1	0	0	0	0	5467	1580	55	0	909	0	FAM131A	3	184062544	Frame_Shift_Del	DEL	TGGG	TCGA-CV-7433-01A-11D-2129-08	27789758	184062544	13959886	28	48283											
GABRA4	2557	broad.mit.edu	37	chr4	46979498	46979498	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagctgtcatattatgtgaGacagatttctttccattcct	9	16	8	8	0	2	2	1	1	1	2	4	4	4	3	2	1	1	1	2	1	2	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr4:46979498G>C	uc003gxg.2	-	4	562	c.423C>G	c.(421-423)GTC>GTG	p.V141V		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	141	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TATTATGTGAGACAGATTTCT	0.299													7	39					0	0	0	0	C	46979498	C	C	46979498	2	2	265	1	0	0	0	0	0	0	0	1	6197	929	33	2		2	GABRA4	4	46979498	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08		46979498	144174778	29	48284											
DCK	1633	broad.mit.edu	37	chr4	71892453	71892453	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaagactttaaagacaaatAtgaaagtctggttgaaaagg	18	10	10	3	0	1	5	0	3	1	2	1	5	1	5	0	2	0	1	0	2	8	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr4:71892453A>T	uc003hfx.2	+	6	1025	c.737A>T	c.(736-738)TAT>TTT	p.Y246F	DCK_uc011cbb.1_Missense_Mutation_p.Y174F	NM_000788	NP_000779	P27707	DCK_HUMAN	deoxycytidine kinase	246					purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			ovary(1)	1			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)	AAAGACAAATATGAAAGTCTG	0.294													11	58					0	0	0	0	T	71892453	T	T	71892453	3	4	265	1	0	0	0	0	1	0	0	0	4307	449	16	5	759	5	DCK	4	71892453	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08	24912955	71892453	119261823	30	48285											
AFM	173	broad.mit.edu	37	chr4	74350051	74350051	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctggtgaaagacatggtaGaatacaaagacagatgtatg	17	8	12	4	0	0	5	0	1	0	4	0	5	0	5	0	2	2	3	0	2	6	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr4:74350051G>C	uc003hhb.2	+	3	245	c.214G>C	c.(214-216)GAA>CAA	p.E72Q		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	72	Albumin 1.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGACATGGTAGAATACAAAGA	0.383													12	97					0	0	0	0	C	74350051	C	C	74350051	3	2	265	1	0	0	0	0	1	0	0	0	361	943	33	2	224	2	AFM	4	74350051	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	2457598	74350051	116804225	31	48286											
BTC	685	broad.mit.edu	37	chr4	75673268	75673268	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actttaagcaatatttgtctCttcaatatcttcattgatag	12	18	4	7	0	4	1	2	1	2	0	5	1	4	1	0	0	1	1	0	0	6	9			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr4:75673268C>T	uc003hig.2	-	5	867	c.520G>A	c.(520-522)GAG>AAG	p.E174K		NM_001729	NP_001720	P35070	BTC_HUMAN	betacellulin precursor	174	Cytoplasmic (Potential).				positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|skin(1)	2			Lung(101;0.219)			ATATTTGTCTCTTCAATATCT	0.338													10	65					0	0	0	0	T	75673268	T	T	75673268	3	4	265	1	0	0	0	0	1	0	0	0	1554	922	32	2	20	2	BTC	4	75673268	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	1323217	75673268	115481008	32	48287											
CNOT6L	246175	broad.mit.edu	37	chr4	78697453	78697453	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctaattctgcccagtgagaTtttttcccattggctacctc	7	16	6	12	0	2	1	0	1	2	1	4	2	3	1	3	1	2	1	3	1	2	7			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr4:78697453T>C	uc011ccd.1	-	2	230	c.99A>G	c.(97-99)AAA>AAG	p.K33K	CNOT6L_uc003hks.2_Silent_p.K33K|CNOT6L_uc011cce.1_Silent_p.K33K	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	33					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						CCCAGTGAGATTTTTTCCCAT	0.373													17	118					0	0	0	0	C	78697453	C	C	78697453	2	2	265	1	0	0	0	0	0	0	0	1	3638	1490	52	5		5	CNOT6L	4	78697453	Silent	SNP	T	TCGA-CV-7433-01A-11D-2129-08	3024185	78697453	112456823	33	48288											
HELQ	113510	broad.mit.edu	37	chr4	84350691	84350691	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttacccttaaatgaagcaCgtcccaactttgtaatatga	13	13	5	10	1	1	2	0	2	1	0	2	2	2	2	2	0	3	2	2	0	7	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr4:84350691C>T	uc003hom.2	-	12	2683	c.2504G>A	c.(2503-2505)CGT>CAT	p.R835H	HELQ_uc010ikb.2_Missense_Mutation_p.R768H|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	835							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						AAATGAAGCACGTCCCAACTT	0.279								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					9	51					0	0	0	0	T	84350691	T	T	84350691	3	4	265	1	0	0	0	0	1	0	0	0	7086	536	19	1	829	1	HELQ	4	84350691	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	5653238	84350691	106803585	34	48289											
NPY1R	4886	broad.mit.edu	37	chr4	164246608	164246608	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggaaatcacaaaagttgaaGaagaactgcaagtctctctg	16	8	9	8	1	3	3	1	1	2	2	4	4	3	4	0	1	2	2	0	1	7	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr4:164246608G>C	uc003iqm.1	-	3	1268	c.1002C>G	c.(1000-1002)TTC>TTG	p.F334L	NPY1R_uc011cjj.1_Missense_Mutation_p.F91L	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	334	Cytoplasmic (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AAAAGTTGAAGAAGAACTGCA	0.418													25	99					0	0	0	0	C	164246608	C	C	164246608	3	2	265	1	0	0	0	0	1	0	0	0	10662	933	33	2	156	2	NPY1R	4	164246608	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	79895917	164246608	26907668	35	48290											
SLC6A19	340024	broad.mit.edu	37	chr5	1212490	1212490	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagacgctcaacatctccaCgtccatcagcgactcgggct	10	7	9	15	4	3	1	2	0	1	1	6	3	4	1	2	1	2	2	2	1	1	0			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr5:1212490C>T	uc003jbw.3	+	4	610	c.554C>T	c.(553-555)ACG>ATG	p.T185M		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	185	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AACATCTCCACGTCCATCAGC	0.617													20	123					0	0	0	0	T	1212490	T	T	1212490	3	4	265	1	0	0	0	0	1	0	0	0	14746	536	19	1	568	1	SLC6A19	5	1212490	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08		1212490	179702770	36	48291											
SLC6A3	6531	broad.mit.edu	37	chr5	1432607	1432607	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggcagcaggtgtggtccCaaaagtgtcgttgaggcccg	7	8	15	11	3	0	1	0	1	0	0	3	1	1	1	2	4	1	3	2	4	2	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr5:1432607C>A	uc003jck.2	-	4	746	c.625G>T	c.(625-627)GGG>TGG	p.G209W		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	209	Extracellular (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	GGTGTGGTCCCAAAAGTGTCG	0.612													7	48					0.000274275	0.000292683	1	0	A	1432607	A	A	1432607	3	1	265	1	0	0	0	0	1	0	0	0	14749	594	21	4	1285	4	SLC6A3	5	1432607	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	220117	1432607	179482653	37	48292											
RICTOR	253260	broad.mit.edu	37	chr5	38957791	38957791	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgttttgctacataacctCtttcattcagataggaaaat	13	16	5	7	0	3	1	2	0	1	1	3	2	3	2	1	1	3	2	1	1	5	8			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr5:38957791C>T	uc003jlp.2	-	25	2486	c.2462G>A	c.(2461-2463)AGA>AAA	p.R821K	RICTOR_uc003jlo.2_Missense_Mutation_p.R821K|RICTOR_uc010ivf.2_Missense_Mutation_p.R536K	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	821					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TACATAACCTCTTTCATTCAG	0.308													10	82					0	0	0	0	T	38957791	T	T	38957791	3	4	265	1	0	0	0	0	1	0	0	0	13423	913	32	2	2720	2	RICTOR	5	38957791	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	37525184	38957791	141957469	38	48293											
TTC33	23548	broad.mit.edu	37	chr5	40716521	40716521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgctgctcctggagcgttCttgcccaagagaggtcttct	5	13	11	12	1	4	1	0	0	4	1	5	3	5	2	2	2	4	3	2	2	1	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr5:40716521C>T	uc003jma.2	-	5	663	c.515G>A	c.(514-516)AGA>AAA	p.R172K	TTC33_uc011cpm.1_Missense_Mutation_p.R64K|TTC33_uc010ivg.2_3'UTR	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	172							binding			ovary(1)	1						CTGGAGCGTTCTTGCCCAAGA	0.423													21	163					0	0	0	0	T	40716521	T	T	40716521	3	4	265	1	0	0	0	0	1	0	0	0	16770	913	32	2	277	2	TTC33	5	40716521	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	1758730	40716521	140198739	39	48294											
CARD6	84674	broad.mit.edu	37	chr5	40854219	40854219	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggggcttcaaatccagctCtccaaatagggtcccatccc	9	9	9	14	0	2	0	1	0	1	0	6	0	5	0	4	3	1	2	4	3	3	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr5:40854219C>A	uc003jmg.2	+	3	2860	c.2785C>A	c.(2785-2787)CTC>ATC	p.L929I		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	929					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						AAATCCAGCTCTCCAAATAGG	0.507													26	154					4.7796e-09	5.50693e-09	1	0	A	40854219	A	A	40854219	3	1	265	1	0	0	0	0	1	0	0	0	2662	913	32	2	2795	2	CARD6	5	40854219	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	137698	40854219	140061041	40	48295											
RGS7BP	401190	broad.mit.edu	37	chr5	63871704	63871704	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctaaaatccatatgtctgCtggggtctcttcagtttcat	8	16	8	9	0	4	0	2	0	2	0	6	0	5	0	1	2	2	3	1	2	3	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr5:63871704C>T	uc003jtj.2	+	3	436	c.436C>T	c.(436-438)CTG>TTG	p.L146L	RGS7BP_uc011cqu.1_Silent_p.L13L	NM_001029875	NP_001025046	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding	146					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane					0		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		CATATGTCTGCTGGGGTCTCT	0.418													5	89					0	0	0	0	T	63871704	T	T	63871704	2	4	265	1	0	0	0	0	0	0	0	1	13376	796	28	4		4	RGS7BP	5	63871704	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	23017485	63871704	117043556	41	48296											
PCDHB7	56129	broad.mit.edu	37	chr5	140552561	140552562	+	Missense_Mutation	DNP	GC	CT	CT																															gcacctttcttaccaacttgGcaaaagacctagggttaggg																										TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr5:140552561_140552562GC>CT	uc003lit.2	+	1	319_320	c.145_146GC>CT	c.(145-147)GCA>CTA	p.A49L		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	49	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TACCAACTTGGCAAAAGACCTA	0.49													11	96					0	0	0	0	CT	140552562	CT	CT	140552561	3	2	265	1	0	0	0	0	1	0	0	0	11601	1203	42	4	147	4	PCDHB7	5	140552561	Missense_Mutation	DNP	GC	TCGA-CV-7433-01A-11D-2129-08	76680857	140552561	40362699	42	48297											
PCDHGA7	56108	broad.mit.edu	37	chr5	140764402	140764402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagagcctcgtggtggccGtccaggaccacggtcagcct	7	6	14	14	3	1	1	1	0	0	1	3	2	2	2	5	4	3	1	5	4	0	0			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr5:140764402G>A	uc003lka.1	+	1	1936	c.1936G>A	c.(1936-1938)GTC>ATC	p.V646I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.V646I	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	646	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGTGGCCGTCCAGGACCA	0.662													13	29					0	0	0	0	A	140764402	A	A	140764402	3	1	265	1	0	0	0	0	1	0	0	0	11613	1145	40	1	1938	1	PCDHGA7	5	140764402	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	211841	140764402	40150858	43	48298											
NR3C1	2908	broad.mit.edu	37	chr5	142779482	142779482	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tattaccaattatatttgctCcaggaaagcttgcctgacag	12	13	7	9	0	0	1	0	1	0	0	1	2	1	2	3	1	4	2	3	1	6	6			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr5:142779482C>G	uc003lmz.2	-	2	1415	c.923G>C	c.(922-924)GGA>GCA	p.G308A	NR3C1_uc003lmy.2_Missense_Mutation_p.G308A|NR3C1_uc003lna.2_Missense_Mutation_p.G308A|NR3C1_uc003lnb.2_Missense_Mutation_p.G308A|NR3C1_uc011dbk.1_Intron|NR3C1_uc003lnc.2_Missense_Mutation_p.G308A|NR3C1_uc003lnd.2_Missense_Mutation_p.G308A|NR3C1_uc003lne.2_Missense_Mutation_p.G308A|NR3C1_uc003lnf.2_Missense_Mutation_p.G308A|NR3C1_uc003lng.2_Missense_Mutation_p.G308A|NR3C1_uc003lnh.2_Missense_Mutation_p.G308A|NR3C1_uc003lni.2_Missense_Mutation_p.G308A	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	308	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	TATATTTGCTCCAGGAAAGCT	0.418													10	140					0	0	0	0	G	142779482	G	G	142779482	3	3	265	1	0	0	0	0	1	0	0	0	10684	855	30	2	1497	2	NR3C1	5	142779482	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	2015080	142779482	38135778	44	48299											
ADRA1B	147	broad.mit.edu	37	chr5	159343986	159343986	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagttgaaaaatgccaactTcactggccccaaccagacct	14	7	7	13	0	1	3	1	1	0	2	1	3	1	3	5	1	3	1	5	1	4	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr5:159343986T>G	uc003lxt.1	+	1	247	c.74T>G	c.(73-75)TTC>TGC	p.F25C		NM_000679	NP_000670	P35368	ADA1B_HUMAN	alpha-1B-adrenergic receptor	25	Extracellular (By similarity).				cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			lung(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	AATGCCAACTTCACTGGCCCC	0.597													5	89					0	0	0	0	G	159343986	G	G	159343986	3	3	265	1	0	0	0	0	1	0	0	0	335	1783	62	5	76	5	ADRA1B	5	159343986	Missense_Mutation	SNP	T	TCGA-CV-7433-01A-11D-2129-08	16564504	159343986	21571274	45	48300											
DSP	1832	broad.mit.edu	37	chr6	7566626	7566626	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagatacgcatgagtcaacTggaagttaaagaaaaagagc	19	6	10	6	1	1	4	1	1	0	3	1	5	1	5	0	1	3	2	0	1	7	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:7566626T>C	uc003mxp.1	+	8	1235	c.956T>C	c.(955-957)CTG>CCG	p.L319P	DSP_uc003mxq.1_Missense_Mutation_p.L319P	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	319	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ATGAGTCAACTGGAAGTTAAA	0.378													8	50					0	0	0	0	C	7566626	C	C	7566626	3	2	265	1	0	0	0	0	1	0	0	0	4803	1580	55	5	986	5	DSP	6	7566626	Missense_Mutation	SNP	T	TCGA-CV-7433-01A-11D-2129-08		7566626	163548441	46	48301											
DSP	1832	broad.mit.edu	37	chr6	7581448	7581448	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccaggaacaggaaagtgtCaaacaagctcacttgaggaa	16	6	10	9	0	2	1	2	1	0	0	3	4	3	4	1	3	3	1	1	3	5	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:7581448C>T	uc003mxp.1	+	23	5304	c.5025C>T	c.(5023-5025)GTC>GTT	p.V1675V	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1675	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGGAAAGTGTCAAACAAGCTC	0.493													12	99					0	0	0	0	T	7581448	T	T	7581448	2	4	265	1	0	0	0	0	0	0	0	1	4803	813	29	2		2	DSP	6	7581448	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	14822	7581448	163533619	47	48302											
DSP	1832	broad.mit.edu	37	chr6	7583519	7583519	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaagaagttgcttctgaaatCcagccattccttcggggtgc	9	11	11	10	1	1	2	0	1	1	1	4	3	3	2	3	2	3	2	3	2	3	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:7583519C>G	uc003mxp.1	+	24	6303	c.6024C>G	c.(6022-6024)ATC>ATG	p.I2008M	DSP_uc003mxq.1_Missense_Mutation_p.I1409M	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2008	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTTCTGAAATCCAGCCATTCC	0.453													6	74					0	0	0	0	G	7583519	G	G	7583519	3	3	265	1	0	0	0	0	1	0	0	0	4803	845	30	2	6118	2	DSP	6	7583519	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	2071	7583519	163531548	48	48303											
DSP	1832	broad.mit.edu	37	chr6	7585993	7585993	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccggctcccgctcgggatCtcgctccggatctcgctccg	2	9	11	19	7	2	0	0	0	2	0	9	2	6	2	4	3	0	4	4	3	0	0			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:7585993C>A	uc003mxp.1	+	24	8777	c.8498C>A	c.(8497-8499)TCT>TAT	p.S2833Y	DSP_uc003mxq.1_Missense_Mutation_p.S2234Y	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2833	6 X 4 AA tandem repeats of G-S-R-[SR].|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		cgctcgggatctcgctccgga	0.413													12	105					1.61879e-10	1.9208e-10	1	0	A	7585993	A	A	7585993	3	1	265	1	0	0	0	0	1	0	0	0	4803	913	32	2	8592	2	DSP	6	7585993	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	2474	7585993	163529074	49	48304											
NOTCH4	4855	broad.mit.edu	37	chr6	32172089	32172089	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggtttgggagtacaggtTccatggttgtgacagggttg	7	12	16	6	0	0	1	0	1	0	0	1	2	1	2	2	5	1	5	2	5	1	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:32172089T>A	uc003obb.2	-	19	3082	c.2943A>T	c.(2941-2943)GGA>GGT	p.G981G	NOTCH4_uc003oba.2_5'Flank|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	981	EGF-like 25.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GAGTACAGGTTCCATGGTTGT	0.562													10	45					0	0	0	0	A	32172089	A	A	32172089	2	1	265	1	0	0	0	0	0	0	0	1	10605	1770	62	5		5	NOTCH4	6	32172089	Silent	SNP	T	TCGA-CV-7433-01A-11D-2129-08	24586096	32172089	138942978	50	48305											
PPP2R5D	5528	broad.mit.edu	37	chr6	42975736	42975736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcctcaagaccattttgcatCgcatctatggcaagtttttg	9	15	7	10	1	2	1	1	0	1	1	4	1	3	1	2	1	1	4	2	1	3	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:42975736C>T	uc003oth.2	+	7	876	c.790C>T	c.(790-792)CGC>TGC	p.R264C	MEA1_uc010jyc.1_Intron|PPP2R5D_uc003otg.2_Missense_Mutation_p.R232C|PPP2R5D_uc010jyd.2_Missense_Mutation_p.R158C|PPP2R5D_uc011dva.1_Missense_Mutation_p.R113C|PPP2R5D_uc003oti.2_Missense_Mutation_p.R113C|PPP2R5D_uc003otj.2_Missense_Mutation_p.R113C	NM_006245	NP_006236	Q14738	2A5D_HUMAN	delta isoform of regulatory subunit B56, protein	264					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			breast(1)|central_nervous_system(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CATTTTGCATCGCATCTATGG	0.537													12	147					0	0	0	0	T	42975736	T	T	42975736	3	4	265	1	0	0	0	0	1	0	0	0	12455	884	31	1	816	1	PPP2R5D	6	42975736	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	10803647	42975736	128139331	51	48306											
SLC35B2	347734	broad.mit.edu	37	chr6	44222466	44222466	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaccttctgcacaggagactCaacaggcacagccttctttc	11	9	7	14	0	3	1	1	0	2	1	4	2	3	1	2	2	4	2	2	2	2	3	rs150122797		TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:44222466C>G	uc003oxd.2	-	4	1412	c.1276G>C	c.(1276-1278)GAG>CAG	p.E426Q	SLC35B2_uc011dvt.1_Missense_Mutation_p.E329Q|SLC35B2_uc011dvu.1_Missense_Mutation_p.E293Q	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	426					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACAGGAGACTCAACAGGCACA	0.602													11	143					0	0	0	0	G	44222466	G	G	44222466	3	3	265	1	0	0	0	0	1	0	0	0	14640	835	29	2	26	2	SLC35B2	6	44222466	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	1246730	44222466	126892601	52	48307											
GPR111	222611	broad.mit.edu	37	chr6	47646751	47646751	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtctgtacagactactccCagtgtactcaaccttgccct	8	12	7	14	0	2	1	1	0	1	1	3	1	3	1	3	0	5	2	3	0	4	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:47646751C>T	uc010jzj.1	+	4	353	c.352C>T	c.(352-354)CAG>TAG	p.Q118*	GPR111_uc010jzk.1_Nonsense_Mutation_p.Q50*|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	118	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						AGACTACTCCCAGTGTACTCA	0.512													9	77					0	0	0	0	T	47646751	T	T	47646751	4	4	265	1	0	0	0	0	0	1	0	0	6666	595	21	4	158	4	GPR111	6	47646751	Nonsense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	3424285	47646751	123468316	53	48308											
COL9A1	1297	broad.mit.edu	37	chr6	70993468	70993468	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggctggcagctcatggcaaGtttctctcctgggccgcagg	5	10	14	12	1	2	0	1	0	1	0	4	0	3	0	2	5	1	6	2	5	1	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:70993468G>A	uc003pfg.3	-	6	911	c.752C>T	c.(751-753)ACT>ATT	p.T251I	COL9A1_uc003pff.3_5'Flank	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	251	Nonhelical region (NC4).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						CTCATGGCAAGTTTCTCTCCT	0.522													3	13					0	0	0	0	A	70993468	A	A	70993468	3	1	265	1	0	0	0	0	1	0	0	0	3722	1029	36	4	2221	4	COL9A1	6	70993468	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	23346717	70993468	100121599	54	48309											
HS3ST5	222537	broad.mit.edu	37	chr6	114378702	114378702	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgtgatgaggcgatctccatCgacgacatgaaattgctcaa	12	9	10	10	4	2	3	1	3	1	0	4	6	2	3	1	1	1	1	1	1	2	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:114378702C>G	uc003pwg.3	-	2	792	c.760G>C	c.(760-762)GAT>CAT	p.D254H	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.D254H	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	254	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		CGATCTCCATCGACGACATGA	0.418													8	81					0	0	0	0	G	114378702	G	G	114378702	3	3	265	1	0	0	0	0	1	0	0	0	7407	884	31	3	284	3	HS3ST5	6	114378702	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	43385234	114378702	56736365	55	48310											
HS3ST5	222537	broad.mit.edu	37	chr6	114378831	114378831	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggtctatggccagcttctCaaacttgtaataagttttgt	10	15	9	7	0	2	0	1	0	2	0	3	0	2	0	1	2	2	3	1	2	4	7			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:114378831C>G	uc003pwg.3	-	2	663	c.631G>C	c.(631-633)GAG>CAG	p.E211Q	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.E211Q	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	211	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GCCAGCTTCTCAAACTTGTAA	0.413													29	287					0	0	0	0	G	114378831	G	G	114378831	3	3	265	1	0	0	0	0	1	0	0	0	7407	835	29	2	413	2	HS3ST5	6	114378831	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	129	114378831	56736236	56	48311											
RSPH4A	345895	broad.mit.edu	37	chr6	116938343	116938343	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtttttcaggaggaagactCaaacagtgactatgatttac	13	12	9	7	1	2	3	2	2	0	1	2	5	2	5	0	2	2	1	0	2	4	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:116938343C>G	uc003pxe.2	+	1	702	c.557C>G	c.(556-558)TCA>TGA	p.S186*	RSPH4A_uc010kee.2_Nonsense_Mutation_p.S186*	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	186					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						GAGGAAGACTCAAACAGTGAC	0.512									Kartagener_syndrome				11	158					0	0	0	0	G	116938343	G	G	116938343	4	3	265	1	0	0	0	0	0	1	0	0	13771	838	29	2	559	2	RSPH4A	6	116938343	Nonsense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	2559512	116938343	54176724	57	48312											
ARHGAP18	93663	broad.mit.edu	37	chr6	129939986	129939986	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacccgttttgtcttttggCaatctgaaactctaaaataa	12	15	6	8	1	3	1	0	1	3	0	3	1	3	1	1	1	2	3	1	1	6	7			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:129939986C>A	uc003qbr.2	-	6	887	c.798G>T	c.(796-798)TTG>TTT	p.L266F	ARHGAP18_uc011ebw.1_Missense_Mutation_p.L266F	NM_033515	NP_277050	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	266					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			ovary(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		TGTCTTTTGGCAATCTGAAAC	0.403													15	66					2.32078e-09	2.71327e-09	1	0	A	129939986	A	A	129939986	3	1	265	1	0	0	0	0	1	0	0	0	868	709	25	4	1233	4	ARHGAP18	6	129939986	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	13001643	129939986	41175081	58	48313											
EYA4	2070	broad.mit.edu	37	chr6	133769304	133769304	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctgagttgcaacaccccCtcttctgcaacaagtatgag	10	11	8	12	0	2	2	0	2	2	0	2	2	2	2	2	0	5	5	2	0	4	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:133769304C>T	uc003qec.3	+	5	722	c.264C>T	c.(262-264)CCC>CCT	p.P88P	EYA4_uc011ecq.1_Intron|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Silent_p.P88P|EYA4_uc003qee.3_Intron|EYA4_uc011ecs.1_Silent_p.P88P|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	88					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		GCAACACCCCCTCTTCTGCAA	0.453													4	58					0	0	0	0	T	133769304	T	T	133769304	2	4	265	1	0	0	0	0	0	0	0	1	5356	668	24	4		4	EYA4	6	133769304	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	3829318	133769304	37345763	59	48314											
PLG	5340	broad.mit.edu	37	chr6	161139457	161139457	+	Frame_Shift_Del	DEL	C	-	-																															gtgcacagacccctcacacaCataacaggacaccagaaaac																										TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr6:161139457delC	uc003qtm.3	+	8	982	c.919delC	c.(919-921)CATfs	p.H307fs		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	307	Kringle 3.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CCCTCACACACATAACAGGAC	0.512													---	---	---								-	161139457	-	-	161139457	7	5	265	1	0	1	0	1	0	0	0	0	12141	478	17	0	953	0	PLG	6	161139457	Frame_Shift_Del	DEL	C	TCGA-CV-7433-01A-11D-2129-08	27370153	161139457	9975610	60	48315											
DNAH11	8701	broad.mit.edu	37	chr7	21747407	21747407	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagctgtgacaacagatgaaCtctttggtttcatacatcat	13	13	7	8	0	3	3	2	2	1	1	3	3	3	3	0	1	4	2	0	1	4	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr7:21747407C>G	uc003svc.2	+	41	6689	c.6658C>G	c.(6658-6660)CTC>GTC	p.L2220V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2220	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AACAGATGAACTCTTTGGTTT	0.393									Kartagener_syndrome				6	31					0	0	0	0	G	21747407	G	G	21747407	3	3	265	1	0	0	0	0	1	0	0	0	4621	565	20	4	6817	4	DNAH11	7	21747407	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08		21747407	137391256	61	48316											
FKBP14	55033	broad.mit.edu	37	chr7	30065984	30065984	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttcatagtggaccaacatCaaatcccctcctttggtctt	9	13	5	14	0	3	0	2	0	1	0	5	1	5	1	5	2	1	0	5	2	3	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr7:30065984C>G	uc003tal.1	-	1	285	c.141G>C	c.(139-141)TTG>TTC	p.L47F	PLEKHA8_uc003tao.2_5'Flank|PLEKHA8_uc003tap.1_5'Flank|FKBP14_uc010kvq.1_RNA|PLEKHA8_uc003tam.1_5'Flank|PLEKHA8_uc003tan.2_5'Flank	NM_017946	NP_060416	Q9NWM8	FKB14_HUMAN	FK506 binding protein 14 precursor	47	PPIase FKBP-type.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						GGACCAACATCAAATCCCCTC	0.428													11	121					0	0	0	0	G	30065984	G	G	30065984	3	3	265	1	0	0	0	0	1	0	0	0	5936	825	29	2	510	2	FKBP14	7	30065984	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	8318577	30065984	129072679	62	48317											
GGCT	79017	broad.mit.edu	37	chr7	30538508	30538508	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttccttcttgagttgcaaCtttaacttctattacaacat	10	19	3	9	0	2	1	0	1	2	0	3	1	3	1	1	0	5	2	1	0	5	10			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr7:30538508C>G	uc003tba.2	-	3	461	c.334G>C	c.(334-336)GTT>CTT	p.V112L	GGCT_uc003tbb.2_Intron|GGCT_uc003tbc.2_RNA|GGCT_uc003taz.2_Missense_Mutation_p.V51L	NM_024051	NP_076956	O75223	GGCT_HUMAN	gamma-glutamyl cyclotransferase	112					release of cytochrome c from mitochondria	cytosol	acyltransferase activity|gamma-glutamylcyclotransferase activity|protein homodimerization activity				0						TGAGTTGCAACTTTAACTTCT	0.373													9	110					0	0	0	0	G	30538508	G	G	30538508	3	3	265	1	0	0	0	0	1	0	0	0	6392	565	20	4	240	4	GGCT	7	30538508	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	472524	30538508	128600155	63	48318											
HIP1	3092	broad.mit.edu	37	chr7	75171237	75171237	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acttacagatggagctctcaCctgagaatccatctcttggc	10	11	8	12	0	2	2	1	1	2	2	5	4	3	3	2	2	2	1	2	2	2	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr7:75171237C>T	uc003uds.1	-	29	2993	c.2952_splice	c.e29+1	p.Q984_splice	HIP1_uc011kfz.1_Splice_Site_p.Q810_splice	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1						activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						GGAGCTCTCACCTGAGAATCC	0.443			T	PDGFRB	CMML								19	80					0	0	0	0	T	75171237	T	T	75171237	5	4	265	1	0	0	0	0	0	0	1	0	7153	521	18	4	172	4	HIP1	7	75171237	Splice_Site	SNP	C	TCGA-CV-7433-01A-11D-2129-08	44632729	75171237	83967426	64	48319											
POR	5447	broad.mit.edu	37	chr7	75612939	75612939	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacctggaattggacatctCggactccaaaatcaggtacc	12	8	9	12	1	2	0	1	0	1	0	4	3	3	3	3	4	1	2	3	4	4	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr7:75612939C>T	uc003udy.2	+	9	1014	c.932C>T	c.(931-933)TCG>TTG	p.S311L	POR_uc011kgc.1_Missense_Mutation_p.S119L|POR_uc011kgd.1_Missense_Mutation_p.S210L|POR_uc011kge.1_Missense_Mutation_p.S49L|POR_uc003uea.2_5'Flank	NM_000941	NP_000932	P16435	NCPR_HUMAN	cytochrome P450 reductase	308	FAD-binding FR-type.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)	1					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	TTGGACATCTCGGACTCCAAA	0.622													15	100					0	0	0	0	T	75612939	T	T	75612939	3	4	265	1	0	0	0	0	1	0	0	0	12312	893	31	1	962	1	POR	7	75612939	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	441702	75612939	83525724	65	48320											
AKAP9	10142	broad.mit.edu	37	chr7	91652175	91652175	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctctgcaagatcttgaaaaaActaaacttgaagaacaagtt	18	10	6	7	0	2	4	0	2	2	2	2	4	2	4	0	0	4	2	0	0	9	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr7:91652175A>T	uc003ulg.2	+	14	4225	c.4000A>T	c.(4000-4002)ACT>TCT	p.T1334S	AKAP9_uc003ule.2_Missense_Mutation_p.T1346S|AKAP9_uc003ulf.2_Missense_Mutation_p.T1334S|AKAP9_uc003uli.2_Missense_Mutation_p.T959S	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1346	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCTTGAAAAAACTAAACTTGA	0.323			T	BRAF	papillary thyroid								7	39					0	0	0	0	T	91652175	T	T	91652175	3	4	265	1	0	0	0	0	1	0	0	0	459	43	2	5	4054	5	AKAP9	7	91652175	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08	16039236	91652175	67486488	66	48321											
IDO1	3620	broad.mit.edu	37	chr8	39782292	39782292	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttcgcatatatttgtctggGtatgtagtcttatgtttgaa	8	19	9	5	1	2	1	0	1	2	0	3	1	2	1	0	1	0	4	0	1	6	8			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr8:39782292G>T	uc003xnm.2	+	8	821	c.707_splice	c.e8+1	p.G236_splice	IDO1_uc003xnn.2_Splice_Site	NM_002164	NP_002155	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1						female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)	2					L-Tryptophan(DB00150)	ATTTGTCTGGGTATGTAGTCT	0.353													4	15					0.00116845	0.00121427	1	0	T	39782292	T	T	39782292	5	4	265	1	0	0	0	0	0	0	1	0	7540	1275	44	4	738	4	IDO1	8	39782292	Splice_Site	SNP	G	TCGA-CV-7433-01A-11D-2129-08		39782292	106581730	67	48322											
VPS13B	157680	broad.mit.edu	37	chr8	100493856	100493856	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctatgaactaactgatatCatgaataaggtctggaacaa	16	12	7	6	0	3	3	1	3	2	0	3	4	3	4	0	2	3	0	0	2	8	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr8:100493856C>A	uc003yiv.2	+	25	3807	c.3696C>A	c.(3694-3696)ATC>ATA	p.I1232I	VPS13B_uc003yiw.2_Silent_p.I1232I|VPS13B_uc003yiu.1_Silent_p.I1232I|VPS13B_uc003yix.1_Silent_p.I702I	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1232					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TAACTGATATCATGAATAAGG	0.393													28	280					1.30897e-18	1.58875e-18	1	0	A	100493856	A	A	100493856	2	1	265	1	0	0	0	0	0	0	0	1	17258	816	29	2		2	VPS13B	8	100493856	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	60711564	100493856	45870166	68	48323											
VPS13B	157680	broad.mit.edu	37	chr8	100796680	100796680	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctccacagtcaccagtacagCtggcgctctcacaaatcccc	10	7	6	18	1	2	0	2	0	1	0	5	0	4	0	4	1	2	3	4	1	2	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr8:100796680C>T	uc003yiv.2	+	43	8103	c.7992C>T	c.(7990-7992)AGC>AGT	p.S2664S	VPS13B_uc003yiw.2_Silent_p.S2639S	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2664					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ACCAGTACAGCTGGCGCTCTC	0.473													38	103					0	0	0	0	T	100796680	T	T	100796680	2	4	265	1	0	0	0	0	0	0	0	1	17258	796	28	4		4	VPS13B	8	100796680	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	302824	100796680	45567342	69	48324											
LRP12	29967	broad.mit.edu	37	chr8	105503225	105503225	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtctcaaaggactctggttCtgacttagggaacttgatcg	9	13	11	8	1	3	2	1	2	3	0	5	4	3	4	0	3	1	1	0	3	3	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr8:105503225C>T	uc003yma.2	-	7	2351	c.2256G>A	c.(2254-2256)CAG>CAA	p.Q752Q	LRP12_uc003ymb.2_Silent_p.Q733Q|LRP12_uc003ylz.2_Silent_p.Q158Q	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	752	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GACTCTGGTTCTGACTTAGGG	0.443													13	110					0	0	0	0	T	105503225	T	T	105503225	2	4	265	1	0	0	0	0	0	0	0	1	9004	912	32	2		2	LRP12	8	105503225	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	4706545	105503225	40860797	70	48325											
ADCY8	114	broad.mit.edu	37	chr8	132002670	132002670	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctgtctccaggcgcagcCtggcctccacacacctccga	6	8	8	19	2	2	0	0	0	2	0	6	1	4	0	6	2	1	1	6	2	0	0			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr8:132002670C>T	uc003ytd.3	-	2	1335	c.1079G>A	c.(1078-1080)AGG>AAG	p.R360K	ADCY8_uc010mds.2_Missense_Mutation_p.R360K	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	360	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CAGGCGCAGCCTGGCCTCCAC	0.502										HNSCC(32;0.087)			27	163					0	0	0	0	T	132002670	T	T	132002670	3	4	265	1	0	0	0	0	1	0	0	0	300	681	24	4	2744	4	ADCY8	8	132002670	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	26499445	132002670	14361352	71	48326											
KIAA1797	54914	broad.mit.edu	37	chr9	20885141	20885141	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgctatgatgtttccatgtAtcagagtaaagatggaaaac	14	13	9	5	0	1	3	1	1	0	2	2	4	2	4	1	1	2	4	1	1	6	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr9:20885141A>G	uc003zog.1	+	23	2900	c.2537A>G	c.(2536-2538)TAT>TGT	p.Y846C	KIAA1797_uc003zoh.1_Missense_Mutation_p.Y282C	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	846						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		GTTTCCATGTATCAGAGTAAA	0.303													16	46					0	0	0	0	G	20885141	G	G	20885141	3	3	265	1	0	0	0	0	1	0	0	0	8297	449	16	5	2615	5	KIAA1797	9	20885141	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08		20885141	120328290	72	48327											
NOTCH1	4851	broad.mit.edu	37	chr9	139412326	139412326	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccgtgtagccctgcagaCactggcactcgaaggagccc	8	5	13	15	2	0	1	0	0	0	1	1	3	0	2	3	3	3	3	3	3	2	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr9:139412326C>A	uc004chz.2	-	8	1319	c.1319G>T	c.(1318-1320)TGT>TTT	p.C440F		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	440	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCCCTGCAGACACTGGCACTC	0.657			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			23	53					2.89027e-11	3.45528e-11	1	0	A	139412326	A	A	139412326	3	1	265	1	0	0	0	0	1	0	0	0	10601	478	17	4	6456	4	NOTCH1	9	139412326	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	118527185	139412326	1801105	73	48328											
RET	5979	broad.mit.edu	37	chr10	43612115	43612115	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatttggaaaagtggtcaaGgcaacggccttccatctgaa	13	9	11	8	1	2	1	1	1	1	0	3	3	3	2	2	4	1	1	2	4	6	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr10:43612115G>T	uc001jal.2	+	12	2410	c.2220G>T	c.(2218-2220)AAG>AAT	p.K740N	RET_uc001jak.1_Missense_Mutation_p.K740N|RET_uc010qez.1_Missense_Mutation_p.K486N	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	740	Protein kinase.|Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	AAGTGGTCAAGGCAACGGCCT	0.532		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				34	143					6.05902e-23	7.41065e-23	1	0	T	43612115	T	T	43612115	3	4	265	1	0	0	0	0	1	0	0	0	13300	991	35	4	2266	4	RET	10	43612115	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08		43612115	91922632	74	48329											
DDX21	9188	broad.mit.edu	37	chr10	70728861	70728861	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtaaaaagactcagaaaaCggcaataactgtggaggtaa	18	7	11	5	1	1	2	1	0	0	2	1	3	1	3	0	4	2	3	0	4	8	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr10:70728861C>T	uc001jov.1	+	7	1310	c.1220C>T	c.(1219-1221)ACG>ATG	p.T407M	DDX21_uc001jow.1_Missense_Mutation_p.T339M	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	407						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						ACTCAGAAAACGGCAATAACT	0.328													9	44					0	0	0	0	T	70728861	T	T	70728861	3	4	265	1	0	0	0	0	1	0	0	0	4366	536	19	1	1246	1	DDX21	10	70728861	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	27116746	70728861	64805886	75	48330											
PDCD4	27250	broad.mit.edu	37	chr10	112641196	112641196	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagcgacagtgggagtgaCgcccttagaagtggattaac	11	8	14	8	2	1	2	1	1	0	1	1	5	1	4	1	2	2	0	1	2	3	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr10:112641196C>T	uc001kzh.2	+	3	492	c.249C>T	c.(247-249)GAC>GAT	p.D83D	PDCD4_uc001kzg.2_Silent_p.D72D|PDCD4_uc010qre.1_Silent_p.D69D	NM_014456	NP_055271	Q53EL6	PDCD4_HUMAN	programmed cell death 4 isoform 1	83					apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		GTGGGAGTGACGCCCTTAGAA	0.502													12	66					0	0	0	0	T	112641196	T	T	112641196	2	4	265	1	0	0	0	0	0	0	0	1	11675	535	19	1		1	PDCD4	10	112641196	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	41912335	112641196	22893551	76	48331											
SPON1	10418	broad.mit.edu	37	chr11	14277228	14277228	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accattccccaggagaaaatCcggcccctgaccagcctgga	11	5	9	16	1	0	2	0	1	0	1	2	4	2	3	8	3	1	0	8	3	2	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr11:14277228C>A	uc001mle.2	+	10	1666	c.1128C>A	c.(1126-1128)ATC>ATA	p.I376I		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	376	Spondin.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		AGGAGAAAATCCGGCCCCTGA	0.488													16	121					2.23348e-06	2.46614e-06	1	0	A	14277228	A	A	14277228	2	1	265	1	0	0	0	0	0	0	0	1	15148	845	30	2		2	SPON1	11	14277228	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08		14277228	120729288	77	48332											
OR4X2	119764	broad.mit.edu	37	chr11	48266856	48266856	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggagatctgctactcctcCgctacagcccccaaactcat	10	9	6	16	1	2	1	1	0	1	1	4	2	4	1	4	1	5	2	4	1	3	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr11:48266856C>T	uc001ngs.1	+	1	201	c.201C>T	c.(199-201)TCC>TCT	p.S67S		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTACTCCTCCGCTACAGCCC	0.502													20	117					0	0	0	0	T	48266856	T	T	48266856	2	4	265	1	0	0	0	0	0	0	0	1	11139	639	23	1		1	OR4X2	11	48266856	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	33989628	48266856	86739660	78	48333											
PLCB3	5331	broad.mit.edu	37	chr11	64032844	64032844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggtcaagctccggagcCggcaagagcgagacctgcgg	8	5	15	13	4	2	2	1	0	1	2	3	4	3	3	3	4	4	2	3	4	2	0			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr11:64032844C>T	uc001nzb.2	+	25	2905	c.2905C>T	c.(2905-2907)CGG>TGG	p.R969W	PLCB3_uc009ypg.1_Missense_Mutation_p.R969W|PLCB3_uc009yph.1_Missense_Mutation_p.R902W|PLCB3_uc009ypi.2_Missense_Mutation_p.R969W	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	969					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						GCTCCGGAGCCGGCAAGAGCG	0.692													7	25					0	0	0	0	T	64032844	T	T	64032844	3	4	265	1	0	0	0	0	1	0	0	0	12084	643	23	1	3003	1	PLCB3	11	64032844	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	15765988	64032844	70973672	79	48334											
LTBP3	4054	broad.mit.edu	37	chr11	65314018	65314018	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcgagcaggggctgccctCggcgcactcgttcacgtctg	5	7	15	14	5	2	0	1	0	1	0	4	1	2	0	1	4	2	4	1	4	0	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr11:65314018C>A	uc001oej.2	-	16	2517	c.2248G>T	c.(2248-2250)GAG>TAG	p.E750*	LTBP3_uc001oef.2_5'Flank|LTBP3_uc001oeg.2_5'UTR|LTBP3_uc001oeh.2_Nonsense_Mutation_p.E180*|LTBP3_uc010roi.1_Nonsense_Mutation_p.E633*|LTBP3_uc001oei.2_Nonsense_Mutation_p.E750*|LTBP3_uc010roj.1_Nonsense_Mutation_p.E451*|LTBP3_uc010rok.1_Nonsense_Mutation_p.E661*	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	750	Cys-rich.|EGF-like 6; calcium-binding (Potential).					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						GGGCTGCCCTCGGCGCACTCG	0.726													5	25					0.00116845	0.00121427	1	0	A	65314018	A	A	65314018	4	1	265	1	0	0	0	0	0	1	0	0	9125	893	31	3	1715	3	LTBP3	11	65314018	Nonsense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	1281174	65314018	69692498	80	48335											
OR10G4	390264	broad.mit.edu	37	chr11	123887153	123887153	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttgtgtacaccctgagaaAcaaggaggtgaagaaagctg	14	8	13	6	0	0	3	0	2	0	2	0	5	0	4	1	2	3	3	1	2	5	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr11:123887153A>G	uc010sac.1	+	1	872	c.872A>G	c.(871-873)AAC>AGC	p.N291S		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	291	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		ACCCTGAGAAACAAGGAGGTG	0.433													22	70					0	0	0	0	G	123887153	G	G	123887153	3	3	265	1	0	0	0	0	1	0	0	0	10955	43	2	5	874	5	OR10G4	11	123887153	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08	58573135	123887153	11119363	81	48336											
HEPACAM	220296	broad.mit.edu	37	chr11	124794745	124794745	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagcagggagccattttcAaagagtcggatacggtctcg	12	8	13	8	3	2	2	1	0	1	2	4	4	2	4	1	3	3	1	1	3	3	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr11:124794745A>G	uc001qbk.2	-	2	712	c.306T>C	c.(304-306)TTT>TTC	p.F102F	HEPACAM_uc009zbj.2_5'Flank|HEPACAM_uc001qbl.1_Silent_p.F102F	NM_152722	NP_689935	Q14CZ8	HECAM_HUMAN	hepatocyte cell adhesion molecule precursor	102	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		AGCCATTTTCAAAGAGTCGGA	0.592													27	118					0	0	0	0	G	124794745	G	G	124794745	2	3	265	1	0	0	0	0	0	0	0	1	7091	127	5	5		5	HEPACAM	11	124794745	Silent	SNP	A	TCGA-CV-7433-01A-11D-2129-08	907592	124794745	10211771	82	48337											
PEX5	5830	broad.mit.edu	37	chr12	7343015	7343015	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggccgaatgcgggggtgcCaacccgctcatgaagctcgc	8	5	15	13	4	1	1	1	1	0	0	2	3	1	1	3	3	4	2	3	3	3	0			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr12:7343015C>T	uc009zfu.1	+	3	622	c.42C>T	c.(40-42)GCC>GCT	p.A14A	PEX5_uc001qsw.2_Silent_p.A14A|PEX5_uc010sgc.1_Silent_p.A14A|PEX5_uc001qsu.2_Silent_p.A14A|PEX5_uc010sgd.1_Silent_p.A35A|PEX5_uc001qsv.2_Silent_p.A14A	NM_001131026	NP_001124498	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5 isoform d	14					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			ovary(1)	1						GCGGGGGTGCCAACCCGCTCA	0.667													18	63					0	0	0	0	T	7343015	T	T	7343015	2	4	265	1	0	0	0	0	0	0	0	1	11803	581	21	4		4	PEX5	12	7343015	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08		7343015	126508880	83	48338											
OLR1	4973	broad.mit.edu	37	chr12	10319441	10319441	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttccttgagttcgttttcTgactcctgtgaagcttcttc	5	19	7	10	1	2	3	0	3	2	0	6	3	4	3	2	0	1	3	2	0	1	7			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr12:10319441T>A	uc001qxo.1	-	3	408	c.294A>T	c.(292-294)TCA>TCT	p.S98S	OLR1_uc010sgz.1_5'UTR|OLR1_uc010sha.1_Silent_p.S98S	NM_002543	NP_002534	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like)	98	Extracellular (Potential).|Neck.|Potential.				blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			ovary(1)	1						GTTCGTTTTCTGACTCCTGTG	0.453													10	147					0	0	0	0	A	10319441	A	A	10319441	2	1	265	1	0	0	0	0	0	0	0	1	10917	1567	55	5		5	OLR1	12	10319441	Silent	SNP	T	TCGA-CV-7433-01A-11D-2129-08	2976426	10319441	123532454	84	48339											
MIP	4284	broad.mit.edu	37	chr12	56848316	56848316	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcgcagtgaggaccccaGcccaaagaagacatagaaga	16	2	11	12	1	0	5	0	1	0	4	0	6	0	6	4	1	2	1	4	1	4	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr12:56848316G>T	uc001slh.2	-	1	114	c.82C>A	c.(82-84)CTG>ATG	p.L28M		NM_012064	NP_036196	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	28	Helical; (By similarity).				response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			skin(1)	1						GAGGACCCCAGCCCAAAGAAG	0.587													8	81					5.4927e-09	6.28302e-09	1	0	T	56848316	T	T	56848316	3	4	265	1	0	0	0	0	1	0	0	0	9644	962	34	4	725	4	MIP	12	56848316	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	46528875	56848316	77003579	85	48340											
INHBC	3626	broad.mit.edu	37	chr12	57828902	57828902	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgaggactgcactgcagcAcctccacggggtcccacagg	8	7	12	14	1	0	1	0	1	0	0	2	2	2	2	3	4	3	3	3	4	0	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr12:57828902A>C	uc001snv.1	+	1	360	c.233A>C	c.(232-234)CAC>CCC	p.H78P		NM_005538	NP_005529	P55103	INHBC_HUMAN	inhibin beta C chain preproprotein	78					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding				0						GCACTGCAGCACCTCCACGGG	0.567													8	47					0	0	0	0	C	57828902	C	C	57828902	3	2	265	1	0	0	0	0	1	0	0	0	7782	159	6	5	235	5	INHBC	12	57828902	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08	980586	57828902	76022993	86	48341											
TBK1	29110	broad.mit.edu	37	chr12	64891448	64891448	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacaagaaactctgcctcaGaaaatgtttacagcttccag	14	11	6	10	0	2	2	1	0	1	2	3	2	3	2	2	0	5	2	2	0	6	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr12:64891448G>C	uc001ssc.1	+	19	2042	c.1980G>C	c.(1978-1980)CAG>CAC	p.Q660H		NM_013254	NP_037386	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	660	Potential.				I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|large_intestine(1)|breast(1)	5				GBM - Glioblastoma multiforme(28;0.0386)		CTCTGCCTCAGAAAATGTTTA	0.328													13	73					0	0	0	0	C	64891448	C	C	64891448	3	2	265	1	0	0	0	0	1	0	0	0	15703	933	33	2	2050	2	TBK1	12	64891448	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	7062546	64891448	68960447	87	48342											
YEATS4	8089	broad.mit.edu	37	chr12	69756669	69756669	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcagtggacagtatatgtGaaaccatatagaaatgaggt	16	10	10	5	0	1	3	1	2	0	1	1	4	1	4	1	2	1	1	1	2	6	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr12:69756669G>C	uc001sux.2	+	2	374	c.153G>C	c.(151-153)GTG>GTC	p.V51V		NM_006530	NP_006521	O95619	YETS4_HUMAN	glioma-amplified sequence-41	51	YEATS.				histone H2A acetylation|histone H4 acetylation|mitosis|positive regulation of transcription, DNA-dependent|regulation of growth	NuA4 histone acetyltransferase complex|nuclear matrix	DNA binding|protein C-terminus binding|sequence-specific DNA binding transcription factor activity|structural constituent of cytoskeleton				0	all_epithelial(5;9.25e-35)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;6.89e-18)|BRCA - Breast invasive adenocarcinoma(5;3.14e-09)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			CAGTATATGTGAAACCATATA	0.343													11	117					0	0	0	0	C	69756669	C	C	69756669	2	2	265	1	0	0	0	0	0	0	0	1	17541	1277	45	2		2	YEATS4	12	69756669	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08	4865221	69756669	64095226	88	48343											
PWP1	11137	broad.mit.edu	37	chr12	108086644	108086644	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacggtctacgggagtaatGatcaagatccttacgttact	11	13	9	8	3	2	2	1	1	1	1	3	3	3	3	1	2	4	2	1	2	6	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr12:108086644G>C	uc001tmo.1	+	4	460	c.373G>C	c.(373-375)GAT>CAT	p.D125H	PWP1_uc001tmn.1_RNA|PWP1_uc009zuu.1_Missense_Mutation_p.D125H	NM_007062	NP_008993	Q13610	PWP1_HUMAN	periodic tryptophan protein 1	125					transcription, DNA-dependent	nucleus					0						CGGGAGTAATGATCAAGATCC	0.348													13	46					0	0	0	0	C	108086644	C	C	108086644	3	2	265	1	0	0	0	0	1	0	0	0	12908	1290	45	2	387	2	PWP1	12	108086644	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	38329975	108086644	25765251	89	48344											
TRPV4	59341	broad.mit.edu	37	chr12	110232203	110232203	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcacacaggtaggagaccacGttgatgtagaaggagacggc	13	5	15	8	2	0	4	0	1	0	3	0	6	0	4	1	4	0	4	1	4	3	3	rs140533102		TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr12:110232203G>A	uc001tpj.1	-	7	1517	c.1422C>T	c.(1420-1422)AAC>AAT	p.N474N	TRPV4_uc001tpg.1_Silent_p.N440N|TRPV4_uc001tph.1_Silent_p.N427N|TRPV4_uc001tpi.1_Silent_p.N367N|TRPV4_uc001tpk.1_Silent_p.N474N|TRPV4_uc001tpl.1_Silent_p.N414N	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	474	Helical; (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AGGAGACCACGTTGATGTAGA	0.622													7	132					0	0	0	0	A	110232203	A	A	110232203	2	1	265	1	0	0	0	0	0	0	0	1	16665	1136	40	1		1	TRPV4	12	110232203	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08	2145559	110232203	23619692	90	48345											
COG3	83548	broad.mit.edu	37	chr13	46067614	46067614	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgcttgaagatcatgtgcaGaacaatggtaaatgagtaga	15	10	12	4	0	1	5	1	2	0	3	1	5	1	5	0	1	3	4	0	1	6	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr13:46067614G>C	uc001vak.2	+	12	1421	c.1320G>C	c.(1318-1320)CAG>CAC	p.Q440H	COG3_uc001vai.2_Missense_Mutation_p.Q440H|COG3_uc001vaj.1_Missense_Mutation_p.Q440H|COG3_uc010tfv.1_Missense_Mutation_p.Q277H|COG3_uc010aci.2_Missense_Mutation_p.Q216H	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	440					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		ATCATGTGCAGAACAATGGTA	0.353													9	86					0	0	0	0	C	46067614	C	C	46067614	3	2	265	1	0	0	0	0	1	0	0	0	3674	933	33	2	1366	2	COG3	13	46067614	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08		46067614	69102264	91	48346											
OR4K2	390431	broad.mit.edu	37	chr14	20345320	20345320	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagaagtaaagatagccatGaggaaactgaaaaataggtt	20	7	10	4	0	0	4	0	2	0	2	0	5	0	5	1	2	2	2	1	2	9	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr14:20345320G>T	uc001vwh.1	+	1	894	c.894G>T	c.(892-894)ATG>ATT	p.M298I		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGATAGCCATGAGGAAACTGA	0.343													12	82					4.3838e-07	4.90862e-07	1	0	T	20345320	T	T	20345320	3	4	265	1	0	0	0	0	1	0	0	0	11126	1290	45	2	896	2	OR4K2	14	20345320	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08		20345320	87004220	92	48347											
OR4K13	390433	broad.mit.edu	37	chr14	20502196	20502196	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcacaactgtgatgtgagctGagagagtggagaaagcctta	13	9	13	6	0	1	5	1	3	0	2	1	7	1	5	1	1	3	1	1	1	3	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr14:20502196G>A	uc010tkz.1	-	1	722	c.722C>T	c.(721-723)TCA>TTA	p.S241L		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GATGTGAGCTGAGAGAGTGGA	0.458													16	49					0	0	0	0	A	20502196	A	A	20502196	3	1	265	1	0	0	0	0	1	0	0	0	11122	1294	45	2	194	2	OR4K13	14	20502196	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	156876	20502196	86847344	93	48348											
IL25	64806	broad.mit.edu	37	chr14	23842343	23842350	+	Frame_Shift_Del	DEL	AGATTAGG	-	-																															tgcagatgagggagcgacccAgattaggtgaggacagttct																										TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr14:23842343_23842350delAGATTAGG	uc001wjr.2	+	1	326_333	c.16_23delAGATTAGG	c.(16-24)AGATTAGGTfs	p.R6fs	IL25_uc001wjq.2_Intron	NM_022789	NP_073626	Q9H293	IL25_HUMAN	interleukin 25 isoform 1 precursor	6_8					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			ovary(1)	1	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		GGAGCGACCCAGATTAGGTGAGGACAGT	0.596													---	---	---								-	23842350	-	-	23842343	7	5	265	1	0	1	0	1	0	0	0	0	7717	180	7	0	31	0	IL25	14	23842343	Frame_Shift_Del	DEL	AGATTAGG	TCGA-CV-7433-01A-11D-2129-08	3340147	23842343	83507197	94	48349											
DAAM1	23002	broad.mit.edu	37	chr14	59789901	59789901	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagaaggttctgcaggccatGctgcactaccagaagtatgc	12	8	11	10	0	1	2	0	0	1	2	1	2	1	2	2	2	5	5	2	2	5	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr14:59789901G>T	uc001xdz.1	+	6	857	c.732G>T	c.(730-732)ATG>ATT	p.M244I	DAAM1_uc001xea.1_Missense_Mutation_p.M244I|DAAM1_uc001xeb.1_Missense_Mutation_p.M244I	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	244	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		TGCAGGCCATGCTGCACTACC	0.552													4	22					1.024e-07	1.15472e-07	1	0	T	59789901	T	T	59789901	3	4	265	1	0	0	0	0	1	0	0	0	4232	1319	46	4	750	4	DAAM1	14	59789901	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	35947558	59789901	47559639	95	48350											
PTPN21	11099	broad.mit.edu	37	chr14	88936012	88936012	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgatcttaaaccttccataGgtgacagtgttgtgcctgga	9	13	11	8	0	1	2	0	2	1	0	2	3	2	3	3	2	2	1	3	2	3	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr14:88936012G>T	uc001xwv.3	-	17	3397	c.3066C>A	c.(3064-3066)ACC>ACA	p.T1022T	PTPN21_uc010twc.1_Silent_p.T818T	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	1022	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						ACCTTCCATAGGTGACAGTGT	0.517													10	62					0.000978159	0.00102998	1	0	T	88936012	T	T	88936012	2	4	265	1	0	0	0	0	0	0	0	1	12851	987	35	4		4	PTPN21	14	88936012	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08	29146111	88936012	18413528	96	48351											
KIAA1409	57578	broad.mit.edu	37	chr14	94007049	94007049	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgctgagcagcgagaacatGagctgaaccggcggcggcag	11	4	16	10	4	0	4	0	3	0	1	0	5	0	4	1	3	6	4	1	3	2	0			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr14:94007049G>A	uc001ybv.1	+	10	948	c.865G>A	c.(865-867)GAG>AAG	p.E289K	KIAA1409_uc001ybs.1_Missense_Mutation_p.E289K|KIAA1409_uc001ybu.1_Missense_Mutation_p.E227K	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	466						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GCGAGAACATGAGCTGAACCG	0.483													11	80					0	0	0	0	A	94007049	A	A	94007049	3	1	265	1	0	0	0	0	1	0	0	0	8269	1291	45	2	903	2	KIAA1409	14	94007049	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	5071037	94007049	13342491	97	48352											
SERPINA4	5267	broad.mit.edu	37	chr14	95030432	95030432	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgagctcaagaaggacGtcttgatggtgctggtgaat	10	11	14	6	1	3	4	2	3	1	1	3	5	3	5	0	3	2	2	0	3	3	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr14:95030432G>A	uc001ydk.2	+	2	679	c.613G>A	c.(613-615)GTC>ATC	p.V205I	SERPINA4_uc010avd.2_Missense_Mutation_p.V242I|SERPINA4_uc001ydl.2_Missense_Mutation_p.V205I	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	205					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		CAAGAAGGACGTCTTGATGGT	0.458													11	205					0	0	0	0	A	95030432	A	A	95030432	3	1	265	1	0	0	0	0	1	0	0	0	14156	1145	40	1	615	1	SERPINA4	14	95030432	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	1023383	95030432	12319108	98	48353											
FRMD5	84978	broad.mit.edu	37	chr15	44202113	44202113	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agctgctaacaaggcagcatCcgatgttttacagaggagtc	12	9	11	9	1	0	1	0	0	0	1	2	3	1	2	1	2	5	5	1	2	3	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr15:44202113C>T	uc001ztl.2	-	5	571	c.394G>A	c.(394-396)GAT>AAT	p.D132N	FRMD5_uc001ztj.1_5'UTR|FRMD5_uc001ztk.1_Missense_Mutation_p.D43N|FRMD5_uc001ztm.2_5'UTR|FRMD5_uc001ztn.2_5'UTR	NM_032892	NP_116281	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5 isoform 2	132	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		AAGGCAGCATCCGATGTTTTA	0.388											OREG0003950	type=REGULATORY REGION|Gene=FRMD5|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	10	59					0	0	0	0	T	44202113	T	T	44202113	3	4	265	1	0	0	0	0	1	0	0	0	6087	855	30	2	1358	2	FRMD5	15	44202113	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08		44202113	58329279	99	48354											
ZNF280D	54816	broad.mit.edu	37	chr15	56961080	56961080	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tataaatgttcgatggtgttGagtcttatgatccattttct	9	19	8	5	1	2	2	0	2	2	0	4	3	3	2	1	1	0	2	1	1	4	7			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr15:56961080G>A	uc002adu.2	-	14	1703	c.1486C>T	c.(1486-1488)CAA>TAA	p.Q496*	ZNF280D_uc002adv.2_Nonsense_Mutation_p.Q483*|ZNF280D_uc010bfq.2_Nonsense_Mutation_p.Q496*|ZNF280D_uc002adw.1_Nonsense_Mutation_p.Q524*|ZNF280D_uc010bfr.1_RNA|ZNF280D_uc010bfp.2_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	496					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		CGATGGTGTTGAGTCTTATGA	0.313													18	74					0	0	0	0	A	56961080	A	A	56961080	4	1	265	1	0	0	0	0	0	1	0	0	17884	1299	45	2	1489	2	ZNF280D	15	56961080	Nonsense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	12758967	56961080	45570312	100	48355											
MAN2A2	4122	broad.mit.edu	37	chr15	91449139	91449139	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacatcctcaatagcatggtGtctaagctgcaggaggaccc	11	8	10	12	0	2	0	1	0	1	0	3	2	3	2	2	3	3	3	2	3	3	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr15:91449139G>T	uc010bnz.2	+	5	715	c.600G>T	c.(598-600)GTG>GTT	p.V200V	MAN2A2_uc010boa.2_Silent_p.V242V|MAN2A2_uc002bqc.2_Silent_p.V200V|MAN2A2_uc010uql.1_5'Flank|MAN2A2_uc010uqm.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	200	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			ATAGCATGGTGTCTAAGCTGC	0.562													4	11					0.00024832	0.000266776	1	0	T	91449139	T	T	91449139	2	4	265	1	0	0	0	0	0	0	0	1	9268	1364	48	4		4	MAN2A2	15	91449139	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08	34488059	91449139	11082253	101	48356											
CASKIN1	57524	broad.mit.edu	37	chr16	2236796	2236796	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgtcatggatgcagcccttCcaccggccatccggatgctg	6	10	11	14	2	1	0	1	0	0	0	3	2	3	2	5	3	3	2	5	3	0	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr16:2236796C>A	uc010bsg.1	-	10	992	c.960G>T	c.(958-960)TGG>TGT	p.W320C		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	320	SH3.				signal transduction	cytoplasm				skin(2)	2						TGCAGCCCTTCCACCGGCCAT	0.662													9	66					0.000673444	0.000713851	1	0	A	2236796	A	A	2236796	3	1	265	1	0	0	0	0	1	0	0	0	2678	856	30	2	3379	2	CASKIN1	16	2236796	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08		2236796	88117957	102	48357											
PRSS22	64063	broad.mit.edu	37	chr16	2903246	2903246	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaccccgggcctgttgcgctCggcacagccctcgccccagc	4	5	12	20	4	0	0	0	0	0	0	2	1	0	0	6	2	3	3	6	2	0	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr16:2903246C>T	uc002cry.1	-	6	868	c.802G>A	c.(802-804)GAG>AAG	p.E268K	PRSS22_uc002crz.1_Missense_Mutation_p.E158K	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	268	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						CTGTTGCGCTCGGCACAGCCC	0.721													11	39					0	0	0	0	T	2903246	T	T	2903246	3	4	265	1	0	0	0	0	1	0	0	0	12681	893	31	1	155	1	PRSS22	16	2903246	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	666450	2903246	87451507	103	48358											
KCTD13	253980	broad.mit.edu	37	chr16	29937220	29937220	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaacgagccgcccacgttCagcttcacgtatttgctgtt	7	12	9	13	4	2	0	2	0	0	0	2	1	2	0	2	0	5	6	2	0	2	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr16:29937220C>T	uc002duv.2	-	1	326	c.135G>A	c.(133-135)CTG>CTA	p.L45L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KCTD13_uc010vee.1_RNA	NM_178863	NP_849194	Q8WZ19	BACD1_HUMAN	potassium channel tetramerisation domain	45	BTB.				cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0						CGCCCACGTTCAGCTTCACGT	0.672													6	39					0	0	0	0	T	29937220	T	T	29937220	2	4	265	1	0	0	0	0	0	0	0	1	8139	813	29	2		2	KCTD13	16	29937220	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	27033974	29937220	60417533	104	48359											
ACD	65057	broad.mit.edu	37	chr16	67691743	67691743	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcagaaccatcacgatgcCtctttgggggttcctgaaag	10	9	12	10	1	2	2	1	1	1	1	3	3	3	2	3	3	2	2	3	3	2	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr16:67691743C>A	uc002etq.3	-	11	1815	c.1478G>T	c.(1477-1479)AGG>ATG	p.R493M	ACD_uc002etp.3_Missense_Mutation_p.R490M|ACD_uc002etr.3_Intron	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	493					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		ATCACGATGCCTCTTTGGGGG	0.587													27	66					2.70662e-09	3.14126e-09	1	0	A	67691743	A	A	67691743	3	1	265	1	0	0	0	0	1	0	0	0	135	681	24	4	164	4	ACD	16	67691743	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	37754523	67691743	22663010	105	48360											
AP1G1	164	broad.mit.edu	37	chr16	71783838	71783838	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acactggccagatacaagaaGatcaccatattcacctatac	16	8	5	12	0	2	3	2	0	0	3	2	3	2	3	3	1	2	0	3	1	6	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr16:71783838G>A	uc010cgg.2	-	15	1770	c.1456C>T	c.(1456-1458)CTT>TTT	p.L486F	AP1G1_uc002fba.2_Missense_Mutation_p.L489F|AP1G1_uc002fbb.2_Missense_Mutation_p.L509F|AP1G1_uc002faz.2_5'Flank	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	486					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				GATACAAGAAGATCACCATAT	0.408													40	225					0	0	0	0	A	71783838	A	A	71783838	3	1	265	1	0	0	0	0	1	0	0	0	732	942	33	2	1048	2	AP1G1	16	71783838	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	4092095	71783838	18570915	106	48361											
DEF8	54849	broad.mit.edu	37	chr16	90030604	90030604	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatcggcagcattttgtggaGaacgacgagatgtactctgt	10	11	13	7	3	1	2	0	0	1	2	2	6	1	2	0	2	3	3	0	2	2	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr16:90030604G>C	uc002fpn.1	+	11	1301	c.1212G>C	c.(1210-1212)GAG>GAC	p.E404D	DEF8_uc002fpo.1_Missense_Mutation_p.E343D|DEF8_uc002fpp.1_Missense_Mutation_p.E333D|DEF8_uc010vpq.1_Missense_Mutation_p.E283D|DEF8_uc010vpr.1_Intron|DEF8_uc002fpq.1_Missense_Mutation_p.E101D	NM_207514	NP_997397	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 isoform 1	404					intracellular signal transduction		zinc ion binding			central_nervous_system(1)	1		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		ATTTTGTGGAGAACGACGAGA	0.657													9	61					0	0	0	0	C	90030604	C	C	90030604	3	2	265	1	0	0	0	0	1	0	0	0	4404	933	33	2	1330	2	DEF8	16	90030604	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	18246766	90030604	324149	107	48362											
TP53	7157	broad.mit.edu	37	chr17	7577106	7577106	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtgcgccggtctctcccagGacaggcacaaacacgcacct	9	6	10	16	3	1	0	0	0	1	0	3	1	2	1	3	3	2	2	3	3	1	0	rs17849781		TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr17:7577106G>A	uc002gim.2	-	8	1026	c.832C>T	c.(832-834)CCT>TCT	p.P278S	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.P278S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P146S|TP53_uc010cng.1_Missense_Mutation_p.P146S|TP53_uc002gii.1_Missense_Mutation_p.P146S|TP53_uc010cnh.1_Missense_Mutation_p.P278S|TP53_uc010cni.1_Missense_Mutation_p.P278S|TP53_uc002gij.2_Missense_Mutation_p.P278S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	278	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P278L(52)|p.P278S(48)|p.P278R(26)|p.P278T(21)|p.P278A(18)|p.P278H(11)|p.0?(7)|p.P278fs*67(5)|p.P278F(3)|p.P278fs*28(2)|p.?(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.P278P(1)|p.C277_P278insXXXXXXX(1)|p.F270_D281del12(1)|p.P278_G279insXXXXX(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTCTCCCAGGACAGGCACAA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	30					0	0	0	0	A	7577106	A	A	7577106	3	1	265	1	0	0	0	0	1	0	0	0	16448	1174	41	2	454	2	TP53	17	7577106	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08		7577106	73618104	108	48363											
MYO15A	51168	broad.mit.edu	37	chr17	18066632	18066632	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catctcaaaatcaaaacatgCactgtaagtgaagaaatgtc	18	9	6	8	0	2	2	2	1	1	1	4	2	2	2	0	0	2	2	0	0	7	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr17:18066632C>T	uc010vxh.1	+	58	10025	c.9687C>T	c.(9685-9687)TGC>TGT	p.C3229C	MYO15A_uc010vxi.1_Silent_p.C493C|MYO15A_uc010vxk.1_5'UTR|MYO15A_uc010vxl.1_Silent_p.C218C|MYO15A_uc002gsl.2_Silent_p.C236C|MYO15A_uc010vxm.1_Silent_p.C151C|MYO15A_uc002gsm.1_Silent_p.C151C|MYO15A_uc010cpv.2_RNA	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3229	Tail.|FERM.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TCAAAACATGCACTGTAAGTG	0.552													12	94					0	0	0	0	T	18066632	T	T	18066632	2	4	265	1	0	0	0	0	0	0	0	1	10116	718	25	4		4	MYO15A	17	18066632	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	10489526	18066632	63128578	109	48364											
SSH2	85464	broad.mit.edu	37	chr17	27999102	27999102	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcctgggtagtagttatgCgctctggcgacttcacaagc	7	11	12	11	2	2	0	1	0	1	0	2	1	2	0	1	2	3	4	1	2	4	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr17:27999102C>T	uc002heo.1	-	8	579	c.579G>A	c.(577-579)GCG>GCA	p.A193A	SSH2_uc010wbh.1_Silent_p.A220A|SSH2_uc002hep.1_Silent_p.A193A	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	193					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						AGTAGTTATGCGCTCTGGCGA	0.473													12	71					0	0	0	0	T	27999102	T	T	27999102	2	4	265	1	0	0	0	0	0	0	0	1	15251	755	27	1		1	SSH2	17	27999102	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	9932470	27999102	53196108	110	48365											
ATAD5	79915	broad.mit.edu	37	chr17	29220393	29220393	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcggaatgtagattttttaTatagtaatcttgagtttatt	11	20	8	2	1	1	2	0	1	1	1	1	3	1	3	0	1	1	3	0	1	7	11			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr17:29220393T>C	uc002hfs.1	+	21	4868	c.4522T>C	c.(4522-4524)TAT>CAT	p.Y1508H		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1508					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGATTTTTTATATAGTAATCT	0.353													25	114					0	0	0	0	C	29220393	C	C	29220393	3	2	265	1	0	0	0	0	1	0	0	0	1078	1406	49	5	4604	5	ATAD5	17	29220393	Missense_Mutation	SNP	T	TCGA-CV-7433-01A-11D-2129-08	1221291	29220393	51974817	111	48366											
TADA2A	6871	broad.mit.edu	37	chr17	35802715	35802715	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actccttgctttctcgggacAtggccgggtacatgccagct	6	11	11	13	2	1	0	0	0	1	0	3	1	2	1	3	3	4	3	3	3	1	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr17:35802715A>G	uc002hnt.2	+	7	650	c.493A>G	c.(493-495)ATG>GTG	p.M165V	TADA2A_uc002hnu.1_Missense_Mutation_p.M165V|TADA2A_uc002hnv.2_Missense_Mutation_p.M165V|TADA2A_uc010wdd.1_Missense_Mutation_p.M165V|TADA2A_uc002hnw.2_Missense_Mutation_p.M64V|TADA2A_uc010cvb.2_Intron	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	165					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						TTCTCGGGACATGGCCGGGTA	0.418													5	56					0	0	0	0	G	35802715	G	G	35802715	3	3	265	1	0	0	0	0	1	0	0	0	15576	217	8	5	515	5	TADA2A	17	35802715	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08	6582322	35802715	45392495	112	48367											
MFSD11	79157	broad.mit.edu	37	chr17	74734467	74734467	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctaaaaagcttttcaacatCattattttaggagttgcctt	12	17	5	7	0	3	0	2	0	1	0	3	1	3	1	1	1	3	2	1	1	6	8			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr17:74734467C>T	uc002jta.2	+	2	1006	c.33C>T	c.(31-33)ATC>ATT	p.I11I	SFRS2_uc002jsv.2_5'Flank|SFRS2_uc002jsw.1_5'Flank|SFRS2_uc002jsx.1_5'Flank|SFRS2_uc002jsy.3_5'Flank|SFRS2_uc010wtg.1_5'Flank|MFSD11_uc002jsz.1_RNA|MIR636_hsa-mir-636|MI0003651_5'Flank|MFSD11_uc002jtb.2_Silent_p.I11I|MFSD11_uc010dha.2_Silent_p.I11I|MFSD11_uc002jtc.2_Silent_p.I11I|MFSD11_uc002jtd.3_Silent_p.I11I|MFSD11_uc010dhb.2_Silent_p.I11I|MFSD11_uc002jte.2_Silent_p.I11I	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	11	Helical; (Potential).					integral to membrane				ovary(1)	1						TTTTCAACATCATTATTTTAG	0.502													4	37					0	0	0	0	T	74734467	T	T	74734467	2	4	265	1	0	0	0	0	0	0	0	1	9582	816	29	2		2	MFSD11	17	74734467	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	38931752	74734467	6460743	113	48368											
KIAA0802	23255	broad.mit.edu	37	chr18	8720391	8720391	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acttaagacggtggaggaaaAgcgcgctaaagctgaggatg	14	6	15	6	3	0	2	0	1	0	1	0	5	0	5	0	4	2	2	0	4	5	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr18:8720391A>T	uc002knr.2	+	4	396	c.254A>T	c.(253-255)AAG>ATG	p.K85M	KIAA0802_uc002knq.2_Missense_Mutation_p.K85M	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	436	Potential.										0						GTGGAGGAAAAGCGCGCTAAA	0.463													9	70					0	0	0	0	T	8720391	T	T	8720391	3	4	265	1	0	0	0	0	1	0	0	0	8233	72	3	5	260	5	KIAA0802	18	8720391	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08		8720391	69356857	114	48369											
BEST2	54831	broad.mit.edu	37	chr19	12866735	12866735	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgagaccaactttctgatcGatagaaacttccaggtgaga	13	11	9	8	1	1	4	0	3	1	3	3	7	2	4	2	1	2	0	2	1	3	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr19:12866735G>A	uc002mux.2	+	7	934	c.934G>A	c.(934-936)GAT>AAT	p.D312N		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	312	Cytoplasmic (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						CTTTCTGATCGATAGAAACTT	0.542													5	56					0	0	0	0	A	12866735	A	A	12866735	3	1	265	1	0	0	0	0	1	0	0	0	1407	1058	37	1	960	1	BEST2	19	12866735	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08		12866735	46262248	115	48370											
ZSWIM4	65249	broad.mit.edu	37	chr19	13941241	13941241	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgtgcgagaagaaccacTcggccttcgaggcggcctac	8	6	12	15	4	0	2	0	0	0	2	2	4	0	2	4	3	3	0	4	3	3	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr19:13941241T>G	uc002mxh.1	+	13	2536	c.2347T>G	c.(2347-2349)TCG>GCG	p.S783A	ZSWIM4_uc010xng.1_Missense_Mutation_p.S706A	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	783							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			GAAGAACCACTCGGCCTTCGA	0.697													13	136					0	0	0	0	G	13941241	G	G	13941241	3	3	265	1	0	0	0	0	1	0	0	0	18310	1551	54	5	2397	5	ZSWIM4	19	13941241	Missense_Mutation	SNP	T	TCGA-CV-7433-01A-11D-2129-08	1074506	13941241	45187742	116	48371											
UBA52	7311	broad.mit.edu	37	chr19	18684147	18684147	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaccctcactggcaaaaccAtcacccttgaggtcgagccc	11	6	8	16	1	2	2	2	1	0	1	3	3	2	2	4	2	2	1	4	2	2	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr19:18684147A>G	uc002njr.2	+	2	151	c.37A>G	c.(37-39)ATC>GTC	p.I13V	UBA52_uc002njs.2_Missense_Mutation_p.I13V|UBA52_uc002njt.2_Missense_Mutation_p.I13V	NM_001033930	NP_001029102	P62987	RL40_HUMAN	ubiquitin and ribosomal protein L40 precursor	13	Ubiquitin-like.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome				0						TGGCAAAACCATCACCCTTGA	0.537													5	37					0	0	0	0	G	18684147	G	G	18684147	3	3	265	1	0	0	0	0	1	0	0	0	16899	217	8	5	39	5	UBA52	19	18684147	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08	4742906	18684147	40444836	117	48372											
CCNE1	898	broad.mit.edu	37	chr19	30312987	30312987	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catatctaaatgacttacatGaagtgctactgccgcagtat	13	12	7	9	1	1	2	0	2	1	0	1	2	1	2	1	0	4	3	1	0	7	5			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr19:30312987G>T	uc002nsn.2	+	9	973	c.790G>T	c.(790-792)GAA>TAA	p.E264*	CCNE1_uc002nso.2_Nonsense_Mutation_p.E249*|CCNE1_uc002nsp.2_Nonsense_Mutation_p.E11*	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	264					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			TGACTTACATGAAGTGCTACT	0.488													8	114					5.18039e-06	5.68057e-06	1	0	T	30312987	T	T	30312987	4	4	265	1	0	0	0	0	0	1	0	0	2935	1291	45	2	820	2	CCNE1	19	30312987	Nonsense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	11628840	30312987	28815996	118	48373											
CCDC8	83987	broad.mit.edu	37	chr19	46914545	46914545	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctctcctgccctggggactCtcttgggcagggttggcaac	4	10	13	14	0	2	0	0	0	2	0	4	1	2	1	3	5	2	3	3	5	1	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr19:46914545C>G	uc002pep.2	-	1	2375	c.1523G>C	c.(1522-1524)AGA>ACA	p.R508T		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	508						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CCTGGGGACTCTCTTGGGCAG	0.622													10	89					0	0	0	0	G	46914545	G	G	46914545	3	3	265	1	0	0	0	0	1	0	0	0	2866	913	32	2	97	2	CCDC8	19	46914545	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	16601558	46914545	12214438	119	48374											
CCDC8	83987	broad.mit.edu	37	chr19	46915167	46915167	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctcttccctttgactatCtgcagcctctcccccctgat	4	13	6	18	0	3	2	0	2	3	0	5	2	4	2	6	1	2	1	6	1	1	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr19:46915167C>T	uc002pep.2	-	1	1753	c.901G>A	c.(901-903)GAT>AAT	p.D301N		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	301						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CTTTGACTATCTGCAGCCTCT	0.627													15	223					0	0	0	0	T	46915167	T	T	46915167	3	4	265	1	0	0	0	0	1	0	0	0	2866	913	32	2	719	2	CCDC8	19	46915167	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	622	46915167	12213816	120	48375											
SOX12	6666	broad.mit.edu	37	chr20	307440	307440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttcgagttcccggactactGcacccccgaggttaccgaga	8	8	10	15	4	0	1	0	0	0	1	2	5	1	2	4	2	3	3	4	2	2	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr20:307440G>A	uc002wdh.2	+	1	1202	c.872G>A	c.(871-873)TGC>TAC	p.C291Y		NM_006943	NP_008874	O15370	SOX12_HUMAN	SRY (sex determining region Y)-box 12	291					cell fate commitment|spinal cord development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|transcription regulatory region sequence-specific DNA binding				0		all_cancers(10;0.000331)|Lung NSC(37;0.0496)|all_lung(30;0.0831)|all_epithelial(17;0.0868)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CCGGACTACTGCACCCCCGAG	0.701													4	30					0	0	0	0	A	307440	A	A	307440	3	1	265	1	0	0	0	0	1	0	0	0	15007	1319	46	4	874	4	SOX12	20	307440	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08		307440	62718080	121	48376											
SIRPB1	10326	broad.mit.edu	37	chr20	1558986	1558986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccacgctgtactcaccgCgcacagacagctcagtgcct	8	6	10	17	3	2	1	2	0	0	1	2	1	2	1	3	1	3	4	3	1	1	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr20:1558986C>T	uc010gai.2	-	2	530	c.431G>A	c.(430-432)CGC>CAC	p.R144H	SIRPB1_uc002wfk.3_Missense_Mutation_p.R144H	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	144	Extracellular (Potential).				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						GTACTCACCGCGCACAGACAG	0.552													30	97					0	0	0	0	T	1558986	T	T	1558986	3	4	265	1	0	0	0	0	1	0	0	0	14398	768	27	1	781	1	SIRPB1	20	1558986	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	1251546	1558986	61466534	122	48377											
JAG1	182	broad.mit.edu	37	chr20	10622312	10622312	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cactcgctgtgccctttgtgGagcaggcaaggtcgagggcc	6	8	15	12	2	0	0	0	0	0	0	2	2	0	1	2	4	2	3	2	4	1	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr20:10622312G>A	uc002wnw.2	-	23	3228	c.2712C>T	c.(2710-2712)CTC>CTT	p.L904L	JAG1_uc010gcd.1_Silent_p.L462L	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	904	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GCCCTTTGTGGAGCAGGCAAG	0.612									Alagille_Syndrome				9	32					0	0	0	0	A	10622312	A	A	10622312	2	1	265	1	0	0	0	0	0	0	0	1	7973	1161	41	2		2	JAG1	20	10622312	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08	9063326	10622312	52403208	123	48378											
ASXL1	171023	broad.mit.edu	37	chr20	31023178	31023178	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaagaaaacttgaaaaccaAggctctcgtttctaacagtt	16	10	6	9	1	2	2	0	1	2	1	3	2	2	2	1	1	3	3	1	1	7	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr20:31023178A>G	uc002wxs.2	+	12	3089	c.2663A>G	c.(2662-2664)AAG>AGG	p.K888R	ASXL1_uc010geb.2_Missense_Mutation_p.K779R	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	888					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.K888fs*6(1)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						TTGAAAACCAAGGCTCTCGTT	0.448			F|N|Mis		MDS|CMML								26	118					0	0	0	0	G	31023178	G	G	31023178	3	3	265	1	0	0	0	0	1	0	0	0	1068	72	3	5	2719	5	ASXL1	20	31023178	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08	20400866	31023178	32002342	124	48379											
NTSR1	4923	broad.mit.edu	37	chr20	61391421	61391421	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggtgaccaacgcactcttCtacgtcagctccaccatcaa	11	9	6	15	2	4	1	2	1	2	0	5	1	5	1	3	1	3	2	3	1	3	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr20:61391421C>G	uc002ydf.2	+	4	1430	c.1059C>G	c.(1057-1059)TTC>TTG	p.F353L		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	353	Helical; Name=7; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			ACGCACTCTTCTACGTCAGCT	0.577													11	219					0	0	0	0	G	61391421	G	G	61391421	3	3	265	1	0	0	0	0	1	0	0	0	10764	912	32	2	1073	2	NTSR1	20	61391421	Missense_Mutation	SNP	C	TCGA-CV-7433-01A-11D-2129-08	30368243	61391421	1634099	125	48380											
KRTAP6-2	337967	broad.mit.edu	37	chr21	31971047	31971047	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catccatagccacagccacaGaagaagcgggagccgtagcc	13	3	11	14	2	0	2	0	0	0	2	1	3	1	3	5	1	5	1	5	1	4	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr21:31971047G>C	uc011adc.1	-	1	147	c.147C>G	c.(145-147)TTC>TTG	p.F49L	KRTAP22-1_uc011add.1_5'Flank	NM_181604	NP_853635	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	49						intermediate filament					0						CACAGCCACAGAAGAAGCGGG	0.552													4	46					0	0	0	0	C	31971047	C	C	31971047	3	2	265	1	0	0	0	0	1	0	0	0	8610	933	33	2	44	2	KRTAP6-2	21	31971047	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08		31971047	16158848	126	48381											
CECR2	27443	broad.mit.edu	37	chr22	18022154	18022154	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgagtacactctgccgtctgGaatgggaaccatggtgctac	9	9	12	11	2	2	0	0	0	2	0	2	3	2	2	2	3	5	2	2	3	4	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr22:18022154G>A	uc010gqw.1	+	15	2382	c.2256G>A	c.(2254-2256)TGG>TGA	p.W752*	CECR2_uc010gqv.1_Nonsense_Mutation_p.W611*|CECR2_uc002zml.2_Nonsense_Mutation_p.W611*	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	794					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		CTGCCGTCTGGAATGGGAACC	0.577													4	34					0	0	0	0	A	18022154	A	A	18022154	4	1	265	1	0	0	0	0	0	1	0	0	3221	1183	41	2	2316	2	CECR2	22	18022154	Nonsense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08		18022154	33282412	127	48382											
SLC2A11	66035	broad.mit.edu	37	chr22	24219248	24219248	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtgagcatgaacatccaGcccatgtacctgggggagag	10	7	15	9	0	0	3	0	2	0	1	1	4	1	3	3	3	4	2	3	3	2	1			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr22:24219248G>A	uc002zyn.3	+	5	525	c.426G>A	c.(424-426)CAG>CAA	p.Q142Q	SLC2A11_uc002zyl.1_Silent_p.Q149Q|SLC2A11_uc002zym.3_Silent_p.Q149Q|SLC2A11_uc002zyo.3_RNA|SLC2A11_uc011ajc.1_Silent_p.Q149Q|SLC2A11_uc011ajd.1_Silent_p.Q136Q|SLC2A11_uc002zyp.3_Silent_p.Q145Q	NM_001024938	NP_001020109	Q9BYW1	GTR11_HUMAN	glucose transporter protein 10 isoform c	142	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity			ovary(1)	1						TGAACATCCAGCCCATGTACC	0.642													12	56					0	0	0	0	A	24219248	A	A	24219248	2	1	265	1	0	0	0	0	0	0	0	1	14604	962	34	4		4	SLC2A11	22	24219248	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08	6197094	24219248	27085318	128	48383											
EMID1	129080	broad.mit.edu	37	chr22	29627077	29627077	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acccctgaggaccctgccccGctctggggtccccctcctgc	3	7	10	21	1	1	1	0	1	1	0	3	2	3	2	8	3	2	1	8	3	0	0			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr22:29627077G>T	uc003aen.2	+	6	603	c.528G>T	c.(526-528)CCG>CCT	p.P176P	EMID1_uc003aem.2_Silent_p.P178P|EMID1_uc003aeo.2_Silent_p.P178P|EMID1_uc003aep.2_Silent_p.P178P	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	EMI domain containing 1	176						collagen					0						ACCCTGCCCCGCTCTGGGGTC	0.582													13	84					2.61681e-11	3.15207e-11	1	0	T	29627077	T	T	29627077	2	4	265	1	0	0	0	0	0	0	0	1	5115	1074	38	3		3	EMID1	22	29627077	Silent	SNP	G	TCGA-CV-7433-01A-11D-2129-08	5407829	29627077	21677489	129	48384											
THOC5	8563	broad.mit.edu	37	chr22	29913096	29913096	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atccacaatgtctttggtgaAgtgcagctcctagaagaggt	11	11	11	8	0	1	3	0	1	1	2	3	3	3	3	2	2	2	2	2	2	4	2			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr22:29913096A>G	uc003afr.2	-	18	1938	c.1603T>C	c.(1603-1605)TTC>CTC	p.F535L	THOC5_uc003afq.2_Missense_Mutation_p.F196L|THOC5_uc003afs.2_Missense_Mutation_p.F535L|THOC5_uc003aft.2_Missense_Mutation_p.F535L|THOC5_uc003afu.2_Missense_Mutation_p.F535L|THOC5_uc010gvo.2_Missense_Mutation_p.F279L	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	535					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						TCTTTGGTGAAGTGCAGCTCC	0.537													14	113					0	0	0	0	G	29913096	G	G	29913096	3	3	265	1	0	0	0	0	1	0	0	0	15934	72	3	5	464	5	THOC5	22	29913096	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08	286019	29913096	21391470	130	48385											
HMGXB4	10042	broad.mit.edu	37	chr22	35660938	35660938	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagacactgacccttcgggAgcctgatggtttaaaaatga	13	9	11	8	1	0	4	0	3	0	1	1	6	0	5	2	2	1	1	2	2	3	3			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr22:35660938A>G	uc003anl.2	+	5	731	c.557A>G	c.(556-558)GAG>GGG	p.E186G	HMGXB4_uc011amh.1_Missense_Mutation_p.E77G|HMGXB4_uc003ank.2_Missense_Mutation_p.E77G	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	186					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						ACCCTTCGGGAGCCTGATGGT	0.463													24	149					0	0	0	0	G	35660938	G	G	35660938	3	3	265	1	0	0	0	0	1	0	0	0	7278	304	11	5	571	5	HMGXB4	22	35660938	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08	5747842	35660938	15643628	131	48386											
KCNJ4	3761	broad.mit.edu	37	chr22	38824021	38824021	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgtccgccatgtagcgctgCgacttgttgctcaggttggc	5	12	13	11	3	1	0	1	0	0	0	2	1	2	0	2	2	3	5	2	2	1	4			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chr22:38824021C>T	uc003avs.1	-	2	214	c.117G>A	c.(115-117)TCG>TCA	p.S39S	KCNJ4_uc003avt.1_Silent_p.S39S	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	39	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					TGTAGCGCTGCGACTTGTTGC	0.612													56	235					0	0	0	0	T	38824021	T	T	38824021	2	4	265	1	0	0	0	0	0	0	0	1	8092	755	27	1		1	KCNJ4	22	38824021	Silent	SNP	C	TCGA-CV-7433-01A-11D-2129-08	3163083	38824021	12480545	132	48387											
MXRA5	25878	broad.mit.edu	37	chrX	3239737	3239737	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtttgtcaacatttgtggcaAcatcatccttaatttctttt	9	19	5	8	0	3	0	2	0	1	0	4	0	4	0	1	1	2	2	1	1	3	6			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chrX:3239737A>G	uc004crg.3	-	5	4146	c.3989T>C	c.(3988-3990)GTT>GCT	p.V1330A		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1330						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ATTTGTGGCAACATCATCCTT	0.378													27	60					0	0	0	0	G	3239737	G	G	3239737	3	3	265	1	0	0	0	0	1	0	0	0	10056	43	2	5	4509	5	MXRA5	23	3239737	Missense_Mutation	SNP	A	TCGA-CV-7433-01A-11D-2129-08		3239737	152030823	133	48388											
USP9X	8239	broad.mit.edu	37	chrX	40990715	40990715	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtaaaacttttaggcctcGatgggtggttccagttttgc	7	15	12	7	1	0	0	0	0	0	0	2	1	1	0	2	4	2	3	2	4	3	6			TCGA-CV-7433-01A-11D-2129-08	TCGA-CV-7433-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	15380da5-6a0b-4649-b21b-ce1ed7d61b67	717e9800-2dac-4894-a61b-8c3cb6082364	g.chrX:40990715G>T	uc004dfb.2	+	4	881	c.248G>T	c.(247-249)CGA>CTA	p.R83L	USP9X_uc004dfc.2_Missense_Mutation_p.R83L	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	83					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TTTAGGCCTCGATGGGTGGTT	0.343													10	44					1.58986e-06	1.76775e-06	1	0	T	40990715	T	T	40990715	3	4	265	1	0	0	0	0	1	0	0	0	17158	1058	37	3	258	3	USP9X	23	40990715	Missense_Mutation	SNP	G	TCGA-CV-7433-01A-11D-2129-08	37750978	40990715	114279845	134	48389											
SPEN	23013	broad.mit.edu	37	chr1	16254617	16254617	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcatcctacgactataacCaagatcgtacatattatgag	14	10	8	9	2	0	2	0	1	0	1	2	3	1	2	2	1	3	2	2	1	7	6			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:16254617C>G	uc001axk.1	+	11	2086	c.1882C>G	c.(1882-1884)CAA>GAA	p.Q628E	SPEN_uc010obp.1_Missense_Mutation_p.Q587E	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	628	Arg-rich.|Tyr-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CGACTATAACCAAGATCGTAC	0.403													32	56					0	0	0	0	G	16254617	G	G	16254617	3	3	266	1	0	0	0	0	1	0	0	0	15104	595	21	4	1924	4	SPEN	1	16254617	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08		16254617	232996004	1	48390											
COL11A1	1301	broad.mit.edu	37	chr1	103471421	103471421	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttgtcacctggcagaccCggaagtccatcaaaccctcg	9	8	8	16	2	2	1	2	0	0	1	4	2	3	2	5	2	1	1	5	2	2	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:103471421C>T	uc001dul.2	-	18	2136	c.1818G>A	c.(1816-1818)CCG>CCA	p.P606P	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Silent_p.P618P|COL11A1_uc001dun.2_Silent_p.P567P|COL11A1_uc009weh.2_Silent_p.P490P	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	606	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGGCAGACCCGGAAGTCCAT	0.303													28	54					0	0	0	0	T	103471421	T	T	103471421	2	4	266	1	0	0	0	0	0	0	0	1	3682	639	23	1		1	COL11A1	1	103471421	Silent	SNP	C	TCGA-CV-7434-01A-11D-2129-08	87216804	103471421	145779200	2	48391											
KCNA10	3744	broad.mit.edu	37	chr1	111060811	111060811	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagaggagccagaactgaCggtggatgtcattggtgggt	11	8	16	6	1	1	3	1	1	0	2	1	5	1	5	1	5	2	0	1	5	2	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:111060811C>T	uc001dzt.1	-	1	987	c.599G>A	c.(598-600)CGT>CAT	p.R200H		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	200			R -> H (in a colorectal cancer sample; somatic mutation).			voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity	p.R200H(1)		ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		CCAGAACTGACGGTGGATGTC	0.547													27	45					0	0	0	0	T	111060811	T	T	111060811	3	4	266	1	0	0	0	0	1	0	0	0	8041	536	19	1	940	1	KCNA10	1	111060811	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	7589390	111060811	138189810	3	48392											
KCNA2	3737	broad.mit.edu	37	chr1	111147063	111147063	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcttctcccagctcataaaaCcgaatttcttcagagaatat	13	13	4	11	1	5	1	2	0	3	1	6	3	5	1	2	0	2	1	2	0	5	5			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:111147063C>T	uc001dzu.2	-	2	838	c.342G>A	c.(340-342)CGG>CGA	p.R114R	KCNA2_uc009wfv.1_Silent_p.R114R|KCNA2_uc009wfw.2_Silent_p.R114R	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	114						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		GCTCATAAAACCGAATTTCTT	0.478													14	34					0	0	0	0	T	111147063	T	T	111147063	2	4	266	1	0	0	0	0	0	0	0	1	8042	494	18	4		4	KCNA2	1	111147063	Silent	SNP	C	TCGA-CV-7434-01A-11D-2129-08	86252	111147063	138103558	4	48393											
RSBN1	54665	broad.mit.edu	37	chr1	114310877	114310877	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtacagctttcaaaactccaAcagcagccgtactctgccag	12	8	7	14	1	2	0	1	0	1	0	3	0	3	0	3	0	8	4	3	0	5	3			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:114310877A>G	uc001edq.2	-	5	1829	c.1793T>C	c.(1792-1794)GTT>GCT	p.V598A	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	598						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAAACTCCAACAGCAGCCGT	0.438													16	35					0	0	0	0	G	114310877	G	G	114310877	3	3	266	1	0	0	0	0	1	0	0	0	13761	43	2	5	627	5	RSBN1	1	114310877	Missense_Mutation	SNP	A	TCGA-CV-7434-01A-11D-2129-08	3163814	114310877	134939744	5	48394											
HIPK1	204851	broad.mit.edu	37	chr1	114506106	114506106	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tactctgagctgcgcagccgGccggccggcgctggttgaac	5	7	15	14	5	1	2	0	2	1	0	1	2	1	2	3	4	5	4	3	4	2	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:114506106G>T	uc001eem.2	+	10	2362	c.2201G>T	c.(2200-2202)GGC>GTC	p.G734V	HIPK1_uc001eel.2_Missense_Mutation_p.G734V|HIPK1_uc001een.2_Missense_Mutation_p.G734V|HIPK1_uc001eeo.2_Missense_Mutation_p.G360V|HIPK1_uc001eep.2_Missense_Mutation_p.G340V|HIPK1_uc001eeq.2_Missense_Mutation_p.G27V	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	734					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGCGCAGCCGGCCGGCCGGCG	0.488													22	42					1.10513e-12	1.36095e-12	1	0	T	114506106	T	T	114506106	3	4	266	1	0	0	0	0	1	0	0	0	7155	1203	42	4	2253	4	HIPK1	1	114506106	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	195229	114506106	134744515	6	48395											
ANKRD35	148741	broad.mit.edu	37	chr1	145562297	145562297	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttgtgcccaagccagaggCgcaggtccagctacagcagt	9	7	13	12	1	0	1	0	0	0	1	1	1	1	1	3	2	5	4	3	2	2	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:145562297C>T	uc001eob.1	+	10	2093	c.1985C>T	c.(1984-1986)GCG>GTG	p.A662V	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.A505V	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	662	Potential.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAGCCAGAGGCGCAGGTCCAG	0.632													19	41					0	0	0	0	T	145562297	T	T	145562297	3	4	266	1	0	0	0	0	1	0	0	0	664	768	27	1	2023	1	ANKRD35	1	145562297	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	31056191	145562297	103688324	7	48396											
FLG	2312	broad.mit.edu	37	chr1	152285838	152285838	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcctgaccctcttgggaCgctgaatgcctggagctgtc	5	11	13	12	1	1	2	0	2	1	0	3	4	2	4	3	2	2	2	3	2	1	1	rs148161383	byFrequency	TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:152285838C>T	uc001ezu.1	-	3	1560	c.1524G>A	c.(1522-1524)GCG>GCA	p.A508A	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	508	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCTTGGGACGCTGAATGCC	0.597									Ichthyosis				143	278					0	0	0	0	T	152285838	T	T	152285838	2	4	266	1	0	0	0	0	0	0	0	1	5954	523	19	1		1	FLG	1	152285838	Silent	SNP	C	TCGA-CV-7434-01A-11D-2129-08	6723541	152285838	96964783	8	48397											
NTRK1	4914	broad.mit.edu	37	chr1	156846199	156846199	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgcttccatccaggcactgaAggaggcgtccgagagtgctc	8	7	13	13	3	0	2	0	1	0	1	4	4	3	3	3	3	1	3	3	3	1	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:156846199A>C	uc001fqh.1	+	14	1696	c.1640A>C	c.(1639-1641)AAG>ACG	p.K547T	NTRK1_uc001fqf.1_Missense_Mutation_p.K511T|NTRK1_uc009wsi.1_Missense_Mutation_p.K246T|NTRK1_uc001fqi.1_Missense_Mutation_p.K541T|NTRK1_uc009wsk.1_Missense_Mutation_p.K544T	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	547	Cytoplasmic (Potential).|Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CAGGCACTGAAGGAGGCGTCC	0.657			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			6	27					0	0	0	0	C	156846199	C	C	156846199	3	2	266	1	0	0	0	0	1	0	0	0	10760	72	3	5	1824	5	NTRK1	1	156846199	Missense_Mutation	SNP	A	TCGA-CV-7434-01A-11D-2129-08	4560361	156846199	92404422	9	48398											
FASLG	356	broad.mit.edu	37	chr1	172634881	172634881	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgaaactgggctgtactttGtatattccaaagtatacttc	12	15	7	7	0	0	1	0	1	0	0	2	1	1	1	1	1	3	4	1	1	7	8			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:172634881G>T	uc001gis.2	+	4	728	c.571G>T	c.(571-573)GTA>TTA	p.V191L	FASLG_uc001git.2_3'UTR	NM_000639	NP_000630	P48023	TNFL6_HUMAN	fas ligand	191	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3						GCTGTACTTTGTATATTCCAA	0.468													25	61					1.42536e-11	1.72339e-11	1	0	T	172634881	T	T	172634881	3	4	266	1	0	0	0	0	1	0	0	0	5714	1377	48	4	585	4	FASLG	1	172634881	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	15788682	172634881	76615740	10	48399											
RASAL2	9462	broad.mit.edu	37	chr1	178423671	178423671	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgctttcttttggagatctCtaatccagacaccatctcaa	10	13	6	12	1	3	2	1	0	3	2	6	3	4	2	2	1	0	1	2	1	2	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:178423671C>G	uc001glr.2	+	10	1780	c.1655C>G	c.(1654-1656)TCT>TGT	p.S552C	RASAL2_uc001glq.2_Missense_Mutation_p.S700C|RASAL2_uc009wxc.2_Missense_Mutation_p.S66C	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	552					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						TTGGAGATCTCTAATCCAGAC	0.423													37	77					0	0	0	0	G	178423671	G	G	178423671	3	3	266	1	0	0	0	0	1	0	0	0	13129	913	32	2	2162	2	RASAL2	1	178423671	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	5788790	178423671	70826950	11	48400											
C1orf27	54953	broad.mit.edu	37	chr1	186367550	186367550	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cttatatccacagcagtaaaCccaaagttaaagatgctgtg	15	10	7	9	0	0	1	0	0	0	1	1	1	1	1	2	0	3	4	2	0	7	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:186367550C>A	uc001grw.2	+	10	1122	c.886C>A	c.(886-888)CCC>ACC	p.P296T	C1orf27_uc010poq.1_Missense_Mutation_p.P273T|C1orf27_uc010por.1_Missense_Mutation_p.P264T|OCLM_uc001gry.2_5'Flank	NM_017847	NP_060317	Q5SWX8	ODR4_HUMAN	odorant response abnormal 4 isoform 1	296						integral to membrane	oxidoreductase activity|zinc ion binding			ovary(1)	1						CAGCAGTAAACCCAAAGTTAA	0.378													28	30					7.41945e-09	8.3626e-09	1	0	A	186367550	A	A	186367550	3	1	266	1	0	0	0	0	1	0	0	0	2046	507	18	4	920	4	C1orf27	1	186367550	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	7943879	186367550	62883071	12	48401											
KCNT2	343450	broad.mit.edu	37	chr1	196309633	196309633	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtagaattcataatgtatcGaggacctggattcagcaaaa	15	11	9	6	1	2	1	2	0	0	1	3	4	2	3	1	2	1	3	1	2	6	5			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:196309633G>A	uc001gtd.1	-	16	1681	c.1621C>T	c.(1621-1623)CGA>TGA	p.R541*	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Nonsense_Mutation_p.R491*|KCNT2_uc001gtf.1_Nonsense_Mutation_p.R541*|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Nonsense_Mutation_p.R541*|KCNT2_uc001gth.1_Nonsense_Mutation_p.R62*	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	541	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						ATAATGTATCGAGGACCTGGA	0.323													14	34					0	0	0	0	A	196309633	A	A	196309633	4	1	266	1	0	0	0	0	0	1	0	0	8131	1066	37	1	1838	1	KCNT2	1	196309633	Nonsense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	9942083	196309633	52940988	13	48402											
KIF14	9928	broad.mit.edu	37	chr1	200555247	200555247	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acctgtaaaagttttatcccTattattccgattctgctgta	10	17	5	9	1	1	0	0	0	1	0	3	1	3	0	3	0	1	4	3	0	6	8			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	c609bd55-58d8-47e2-a609-40fb839ef1e8	g.chr1:200555247T>C	uc010ppk.1	-	19	3662	c.3223A>G	c.(3223-3225)AGG>GGG	p.R1075G	KIF14_uc010ppj.1_Missense_Mutation_p.R584G	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1075	Potential.|Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						GTTTTATCCCTATTATTCCGA	0.303													3	42					0	0	0	0	C	200555247	C	C	200555247	3	2	266	1	0	0	0	0	1	0	0	0	8315	1521	53	5	1771	5	KIF14	1	200555247	Missense_Mutation	SNP	T	TCGA-CV-7434-01A-11D-2129-08	4245614	200555247	48695374	14	48403											
OBSCN	84033	broad.mit.edu	37	chr1	228434319	228434319	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacactgagctgtgaggtggCccaggcccagacagaggtga	10	5	15	11	0	0	5	0	3	0	2	0	5	0	5	2	4	1	1	2	4	0	0			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:228434319C>A	uc009xez.1	+	13	3892	c.3848C>A	c.(3847-3849)GCC>GAC	p.A1283D	OBSCN_uc001hsn.2_Missense_Mutation_p.A1283D	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1283	Ig-like 13.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGTGAGGTGGCCCAGGCCCAG	0.612													33	45					2.85442e-18	3.6858e-18	1	0	A	228434319	A	A	228434319	3	1	266	1	0	0	0	0	1	0	0	0	10866	739	26	4	3894	4	OBSCN	1	228434319	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	27879072	228434319	20816302	15	48404											
C1orf198	84886	broad.mit.edu	37	chr1	231004121	231004121	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcgcggatcttctccttGtcctgcatgatcttcctggc	3	16	8	14	2	4	1	0	1	4	0	8	2	6	2	3	2	1	1	3	2	0	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr1:231004121G>T	uc001hub.2	-	1	182	c.138C>A	c.(136-138)GAC>GAA	p.D46E	C1orf198_uc001huc.1_Intron|C1orf198_uc001hud.1_Missense_Mutation_p.D8E	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	46											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TCTTCTCCTTGTCCTGCATGA	0.612													15	16					1.15088e-07	1.23441e-07	1	0	T	231004121	T	T	231004121	3	4	266	1	0	0	0	0	1	0	0	0	2035	1368	48	4	861	4	C1orf198	1	231004121	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	2569802	231004121	18246500	16	48405											
CCDC85A	114800	broad.mit.edu	37	chr2	56420052	56420052	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcccggagcacctgcagaaGccccggagcgagggcagccc	9	1	15	16	3	0	1	0	0	0	1	0	4	0	3	5	3	6	3	5	3	1	0			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr2:56420052G>A	uc002rzn.2	+	2	1219	c.717G>A	c.(715-717)AAG>AAA	p.K239K		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	239	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACCTGCAGAAGCCCCGGAGCG	0.672													16	18					0	0	0	0	A	56420052	A	A	56420052	2	1	266	1	0	0	0	0	0	0	0	1	2872	962	34	4		4	CCDC85A	2	56420052	Silent	SNP	G	TCGA-CV-7434-01A-11D-2129-08		56420052	186779321	17	48406											
ANKRD36	375248	broad.mit.edu	37	chr2	97784187	97784187	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctctgcactacgctgtgtAtaatgaagatacatccatga	12	12	8	9	1	1	3	0	2	1	1	2	3	2	3	1	0	4	4	1	0	5	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr2:97784187A>G	uc010yva.1	+	3	663	c.419A>G	c.(418-420)TAT>TGT	p.Y140C	ANKRD36_uc002sxn.2_Missense_Mutation_p.Y140C|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Missense_Mutation_p.Y140C|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	140	ANK 4.										0						TACGCTGTGTATAATGAAGAT	0.398													21	11					0	0	0	0	G	97784187	G	G	97784187	3	3	266	1	0	0	0	0	1	0	0	0	665	449	16	5	429	5	ANKRD36	2	97784187	Missense_Mutation	SNP	A	TCGA-CV-7434-01A-11D-2129-08	41364135	97784187	145415186	18	48407											
SCN9A	6335	broad.mit.edu	37	chr2	167055277	167055277	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggctttgttacactatcatAtgaaggtggagaggtggtgg	9	13	15	4	0	1	2	1	1	0	1	1	3	1	2	0	6	1	2	0	6	4	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr2:167055277A>G	uc010fpl.2	-	27	6180	c.5839T>C	c.(5839-5841)TAT>CAT	p.Y1947H	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1958						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	ACACTATCATATGAAGGTGGA	0.358													3	17					0	0	0	0	G	167055277	G	G	167055277	3	3	266	1	0	0	0	0	1	0	0	0	13990	449	16	5	98	5	SCN9A	2	167055277	Missense_Mutation	SNP	A	TCGA-CV-7434-01A-11D-2129-08	69271090	167055277	76144096	19	48408											
FARSB	10056	broad.mit.edu	37	chr2	223497951	223497951	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcattgaaaggacgacacCattgctatcatagataactg	15	9	9	8	1	1	2	1	1	0	1	1	4	1	3	1	2	2	2	1	2	4	5			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr2:223497951C>A	uc002vne.1	-	7	717	c.682G>T	c.(682-684)GGT>TGT	p.G228C	FARSB_uc010zlq.1_Missense_Mutation_p.G248C|FARSB_uc002vnf.1_Missense_Mutation_p.G129C	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	228					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	AGGACGACACCATTGCTATCA	0.333													32	83					9.62906e-15	1.20817e-14	1	0	A	223497951	A	A	223497951	3	1	266	1	0	0	0	0	1	0	0	0	5712	594	21	4	1131	4	FARSB	2	223497951	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	56442674	223497951	19701422	20	48409											
ARMC9	80210	broad.mit.edu	37	chr2	232209757	232209757	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggagcggggatgagccccTgcaaaggcccgtcacccccg	7	4	15	15	3	1	1	1	1	0	0	1	3	1	3	5	4	3	1	5	4	1	0			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr2:232209757T>A	uc002vrq.3	+	21	2061	c.1949T>A	c.(1948-1950)CTG>CAG	p.L650Q	ARMC9_uc002vrp.3_Missense_Mutation_p.L650Q|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	650							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		GATGAGCCCCTGCAAAGGCCC	0.547													33	52					0	0	0	0	A	232209757	A	A	232209757	3	1	266	1	0	0	0	0	1	0	0	0	960	1580	55	5	2027	5	ARMC9	2	232209757	Missense_Mutation	SNP	T	TCGA-CV-7434-01A-11D-2129-08	8711806	232209757	10989616	21	48410											
PLXNB1	5364	broad.mit.edu	37	chr3	48451945	48451945	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcgtcagaaagaatgaggtgCccggccaccccagaccgcca	11	4	11	15	3	1	4	1	1	0	3	2	4	1	4	6	2	1	0	6	2	2	0			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:48451945C>A	uc003csw.2	-	30	5709	c.5439G>T	c.(5437-5439)GGG>GGT	p.G1813G	PLXNB1_uc003cst.2_Silent_p.G263G|PLXNB1_uc003csu.2_Silent_p.G1630G|PLXNB1_uc003csx.2_Silent_p.G1813G	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	1813	Cytoplasmic (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAATGAGGTGCCCGGCCACCC	0.597													18	21					4.96729e-08	5.41516e-08	1	0	A	48451945	A	A	48451945	2	1	266	1	0	0	0	0	0	0	0	1	12178	726	26	4		4	PLXNB1	3	48451945	Silent	SNP	C	TCGA-CV-7434-01A-11D-2129-08		48451945	149570485	22	48411											
SHISA5	51246	broad.mit.edu	37	chr3	48510918	48510918	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgggcggcacacttggaGgctgaggataaggggcatgc	9	6	18	8	1	0	1	0	1	0	0	0	3	0	3	0	7	2	4	0	7	1	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:48510918G>T	uc003ctp.1	-	5	619	c.485C>A	c.(484-486)CCT>CAT	p.P162H	SHISA5_uc003ctn.1_Silent_p.A30A|SHISA5_uc003ctm.1_Missense_Mutation_p.P59H|SHISA5_uc011bbk.1_Silent_p.A70A|SHISA5_uc003cto.1_Missense_Mutation_p.P131H|SHISA5_uc003ctq.1_Missense_Mutation_p.P155H|SHISA5_uc003ctr.1_Missense_Mutation_p.P131H|SHISA5_uc003cts.1_Missense_Mutation_p.P131H|SHISA5_uc003ctt.2_Missense_Mutation_p.P59H|SHISA5_uc003ctu.1_RNA|SHISA5_uc011bbl.1_Missense_Mutation_p.P60H	NM_016479	NP_057563	Q8N114	SHSA5_HUMAN	scotin precursor	162	Cytoplasmic (Potential).|Pro-rich.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	signal transducer activity|WW domain binding				0						CACACTTGGAGGCTGAGGATA	0.607													13	20					2.27111e-07	2.41646e-07	1	0	T	48510918	T	T	48510918	3	4	266	1	0	0	0	0	1	0	0	0	14348	1000	35	4	245	4	SHISA5	3	48510918	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	58973	48510918	149511512	23	48412											
RNF123	63891	broad.mit.edu	37	chr3	49742142	49742142	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagctccagtcaaccgccAtggatgacctagatgaggat	11	8	12	10	1	1	3	1	2	0	1	2	6	2	6	4	3	2	1	4	3	2	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:49742142A>G	uc003cxh.2	+	22	1998	c.1912A>G	c.(1912-1914)ATG>GTG	p.M638V	RNF123_uc010hky.1_Missense_Mutation_p.M300V|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	638						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GTCAACCGCCATGGATGACCT	0.587													4	6					0	0	0	0	G	49742142	G	G	49742142	3	3	266	1	0	0	0	0	1	0	0	0	13498	217	8	5	1994	5	RNF123	3	49742142	Missense_Mutation	SNP	A	TCGA-CV-7434-01A-11D-2129-08	1231224	49742142	148280288	24	48413											
EPHB1	2047	broad.mit.edu	37	chr3	134884901	134884901	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgtgtccttggtggccatCtctatcgtctgtagcaggta	5	15	12	9	1	2	0	0	0	2	0	5	0	3	0	2	3	1	4	2	3	3	5			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:134884901C>T	uc003eqt.2	+	8	1897	c.1677C>T	c.(1675-1677)ATC>ATT	p.I559I	EPHB1_uc003equ.2_Silent_p.I120I	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	559	Helical; (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TGGTGGCCATCTCTATCGTCT	0.587													32	106					0	0	0	0	T	134884901	T	T	134884901	2	4	266	1	0	0	0	0	0	0	0	1	5198	903	32	2		2	EPHB1	3	134884901	Silent	SNP	C	TCGA-CV-7434-01A-11D-2129-08	85142759	134884901	63137529	25	48414											
ZIC1	7545	broad.mit.edu	37	chr3	147128258	147128258	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccagcgcacagcacagccTctttgctgcatcggccgggg	7	6	13	15	3	1	0	0	0	1	0	2	0	1	0	3	3	6	4	3	3	0	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:147128258T>C	uc003ewe.2	+	1	1078	c.359T>C	c.(358-360)CTC>CCC	p.L120P		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	120					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CAGCACAGCCTCTTTGCTGCA	0.706													16	40					0	0	0	0	C	147128258	C	C	147128258	3	2	266	1	0	0	0	0	1	0	0	0	17745	1551	54	5	361	5	ZIC1	3	147128258	Missense_Mutation	SNP	T	TCGA-CV-7434-01A-11D-2129-08	12243357	147128258	50894172	26	48415											
ATP11B	23200	broad.mit.edu	37	chr3	182597414	182597414	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagctgtattatgctgtcgtAtggctccactgcagaaagca	10	11	10	10	1	0	1	0	0	0	1	2	1	1	1	1	1	4	7	1	1	4	3			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:182597414A>G	uc003flb.2	+	20	2640	c.2383A>G	c.(2383-2385)ATG>GTG	p.M795V	ATP11B_uc003flc.2_Missense_Mutation_p.M379V|ATP11B_uc011bqm.1_Missense_Mutation_p.M99V|ATP11B_uc010hxf.1_5'UTR	NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	795	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			ATGCTGTCGTATGGCTCCACT	0.353													22	67					0	0	0	0	G	182597414	G	G	182597414	3	3	266	1	0	0	0	0	1	0	0	0	1122	449	16	5	2461	5	ATP11B	3	182597414	Missense_Mutation	SNP	A	TCGA-CV-7434-01A-11D-2129-08	35469156	182597414	15425016	27	48416											
CCDC50	152137	broad.mit.edu	37	chr3	191098615	191098615	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atattgactgtattttgtttAggaaatcgctcgacttctaa	11	17	7	6	2	1	1	0	1	1	0	3	3	1	2	0	1	0	3	0	1	5	9			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr3:191098615A>C	uc003fsw.2	+	8	1200	c.610_splice	c.e8-2	p.E204_splice	CCDC50_uc003fsv.2_Splice_Site_p.E380_splice	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform							cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		TATTTTGTTTAGGAAATCGCT	0.368													11	42					0	0	0	0	C	191098615	C	C	191098615	5	2	266	1	0	0	0	0	0	0	1	0	2833	434	15	5	1170	5	CCDC50	3	191098615	Splice_Site	SNP	A	TCGA-CV-7434-01A-11D-2129-08	8501201	191098615	6923815	28	48417											
GPR125	166647	broad.mit.edu	37	chr4	22439976	22439976	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtcctcgtattattcccacGtttggtctggacatgacagc	8	13	9	11	2	1	1	0	1	1	0	4	2	3	2	2	2	1	2	2	2	2	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr4:22439976G>A	uc003gqm.1	-	8	1253	c.988C>T	c.(988-990)CGT>TGT	p.R330C	GPR125_uc010ieo.1_Missense_Mutation_p.R204C|GPR125_uc003gqn.1_Missense_Mutation_p.R104C|GPR125_uc003gqo.2_Missense_Mutation_p.R330C	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	330	Extracellular (Potential).|Ig-like.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				TTATTCCCACGTTTGGTCTGG	0.423													29	46					0	0	0	0	A	22439976	A	A	22439976	3	1	266	1	0	0	0	0	1	0	0	0	6677	1145	40	1	3025	1	GPR125	4	22439976	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08		22439976	168714300	29	48418											
SHROOM3	57619	broad.mit.edu	37	chr4	77676119	77676119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatatctgagtctgtcctgCgggactccccgccacctcat	7	10	9	15	2	3	1	1	1	2	0	5	3	5	2	5	1	1	0	5	1	2	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr4:77676119C>T	uc011cbx.1	+	7	5436	c.4483C>T	c.(4483-4485)CGG>TGG	p.R1495W	SHROOM3_uc003hkg.2_Missense_Mutation_p.R1273W	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1495					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GTCTGTCCTGCGGGACTCCCC	0.577													20	55					0	0	0	0	T	77676119	T	T	77676119	3	4	266	1	0	0	0	0	1	0	0	0	14360	759	27	1	4509	1	SHROOM3	4	77676119	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	55236143	77676119	113478157	30	48419											
CENPE	1062	broad.mit.edu	37	chr4	104070291	104070291	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttactgtagcttcaatttctCttatatatcctctaaggtgg	9	18	6	8	0	3	0	1	0	2	0	5	0	4	0	1	2	2	2	1	2	7	8			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr4:104070291C>G	uc003hxb.1	-	27	3761	c.3671G>C	c.(3670-3672)AGA>ACA	p.R1224T	CENPE_uc003hxc.1_Missense_Mutation_p.R1199T	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1224	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTCAATTTCTCTTATATATCC	0.338													21	39					0	0	0	0	G	104070291	G	G	104070291	3	3	266	1	0	0	0	0	1	0	0	0	3245	913	32	2	4526	2	CENPE	4	104070291	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	26394172	104070291	87083985	31	48420											
SEC24B	10427	broad.mit.edu	37	chr4	110442694	110442694	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtctccaacaggtggccGtgtgtctgtatttcagacac	9	12	10	10	1	3	1	1	0	2	1	4	1	3	1	2	2	1	1	2	2	3	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr4:110442694G>T	uc003hzk.2	+	14	2475	c.2420G>T	c.(2419-2421)CGT>CTT	p.R807L	SEC24B_uc003hzl.2_Missense_Mutation_p.R772L|SEC24B_uc011cfp.1_Missense_Mutation_p.R837L|SEC24B_uc011cfq.1_Missense_Mutation_p.R806L|SEC24B_uc011cfr.1_Missense_Mutation_p.R771L	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	807					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		ACAGGTGGCCGTGTGTCTGTA	0.428													18	21					4.96729e-08	5.41516e-08	1	0	T	110442694	T	T	110442694	3	4	266	1	0	0	0	0	1	0	0	0	14060	1145	40	3	2474	3	SEC24B	4	110442694	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	6372403	110442694	80711582	32	48421											
HELT	391723	broad.mit.edu	37	chr4	185940787	185940787	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgagcgcagggcgaacctCaggaggctctggcgcagatc	8	5	15	13	3	2	2	1	1	1	1	3	4	2	3	2	4	2	3	2	4	1	0			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr4:185940787C>T	uc011ckq.1	+	3	274	c.274C>T	c.(274-276)CAG>TAG	p.Q92*	HELT_uc011cko.1_Intron|HELT_uc003ixa.3_Intron|HELT_uc011ckp.1_5'UTR	NM_001029887	NP_001025058	A6NFD8	HELT_HUMAN	HES/HEY-like transcription factor	92	Helix-loop-helix motif.						DNA binding				0		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;8.92e-26)|Epithelial(43;3.02e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-11)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GGGCGAACCTCAGGAGGCTCT	0.746													3	13					0	0	0	0	T	185940787	T	T	185940787	4	4	266	1	0	0	0	0	0	1	0	0	7087	827	29	2	284	2	HELT	4	185940787	Nonsense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	75498093	185940787	5213489	33	48422											
TIMD4	91937	broad.mit.edu	37	chr5	156346537	156346537	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaggacatttttactatcTccaatgtagtctagcctgta	10	16	7	8	0	2	1	0	1	2	0	3	2	2	2	2	1	2	2	2	1	6	8			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr5:156346537T>A	uc003lwh.2	-	9	1125	c.1068A>T	c.(1066-1068)GGA>GGT	p.G356G	TIMD4_uc010jii.2_Silent_p.G328G|TIMD4_uc003lwg.2_Silent_p.G58G	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	356	Cytoplasmic (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTTACTATCTCCAATGTAGT	0.423													19	37					0	0	0	0	A	156346537	A	A	156346537	2	1	266	1	0	0	0	0	0	0	0	1	15969	1538	54	5		5	TIMD4	5	156346537	Silent	SNP	T	TCGA-CV-7434-01A-11D-2129-08		156346537	24568723	34	48423											
ME1	4199	broad.mit.edu	37	chr6	83937086	83937091	+	In_Frame_Del	DEL	ATTCTG	-	-																															gtagcactgctctgcagaacAttctgctttgctagttggat																										TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:83937086_83937091delATTCTG	uc003pjy.2	-	11	1344_1349	c.1238_1243delCAGAAT	c.(1237-1245)GCAGAATGT>GGT	p.413_415AEC>G	ME1_uc011dzb.1_In_Frame_Del_p.338_340AEC>G|ME1_uc011dzc.1_In_Frame_Del_p.247_249AEC>G	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	413_415					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	TCTGCAGAACATTCTGCTTTGCTAGT	0.35													---	---	---								-	83937091	-	-	83937086	7	5	266	1	0	1	0	1	0	0	0	0	9470	217	8	0	491	0	ME1	6	83937086	In_Frame_Del	DEL	ATTCTG	TCGA-CV-7434-01A-11D-2129-08		83937086	87177981	35	48424											
OSTM1	28962	broad.mit.edu	37	chr6	108370556	108370556	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cacagaaacagcaattacagGcactgtgtcactgcaaggga	15	6	10	10	0	1	1	1	0	0	1	1	2	1	2	0	2	4	3	0	2	4	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:108370556G>A	uc003psd.2	-	5	936	c.850C>T	c.(850-852)CCT>TCT	p.P284S		NM_014028	NP_054747	Q86WC4	OSTM1_HUMAN	osteopetrosis associated transmembrane protein 1	284	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0131)|Epithelial(106;0.0438)|OV - Ovarian serous cystadenocarcinoma(136;0.0571)|all cancers(137;0.0581)		GCAATTACAGGCACTGTGTCA	0.398													20	119					0	0	0	0	A	108370556	A	A	108370556	3	1	266	1	0	0	0	0	1	0	0	0	11352	1203	42	4	162	4	OSTM1	6	108370556	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	24433470	108370556	62744511	36	48425											
LACE1	246269	broad.mit.edu	37	chr6	108645100	108645100	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttatttgaaagctttggccGtttgccatggacctctggac	7	14	10	10	1	1	1	0	1	1	0	1	3	1	3	3	3	2	2	3	3	2	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:108645100G>A	uc003psj.2	+	2	397	c.211G>A	c.(211-213)GTT>ATT	p.V71I		NM_145315	NP_660358	Q8WV93	LACE1_HUMAN	lactation elevated 1	71							ATP binding			central_nervous_system(1)	1		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		AGCTTTGGCCGTTTGCCATGG	0.398													118	74					0	0	0	0	A	108645100	A	A	108645100	3	1	266	1	0	0	0	0	1	0	0	0	8635	1145	40	1	217	1	LACE1	6	108645100	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	274544	108645100	62469967	37	48426											
DCBLD1	285761	broad.mit.edu	37	chr6	117865742	117865742	+	Splice_Site	DEL	T	-	-																															gcagaggctcagaaaacaggTtggttgaaaactctatctac																										TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:117865742delT	uc003pxs.2	+	13	1620	c.1495_splice	c.e13+2	p.D499_splice	GOPC_uc003pxq.1_Intron|DCBLD1_uc003pxr.1_Splice_Site_p.Q497_splice|DCBLD1_uc003pxt.1_Splice_Site_p.D154_splice	NM_173674	NP_775945	Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1						cell adhesion	integral to membrane				ovary(1)	1		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		AGAAAACAGGTTGGTTGAAAA	0.393													---	---	---								-	117865742	-	-	117865742	8	5	266	1	0	1	0	1	0	0	1	0	4297	1739	60	0	1547	0	DCBLD1	6	117865742	Splice_Site	DEL	T	TCGA-CV-7434-01A-11D-2129-08	9220642	117865742	53249325	38	48427											
ACAT2	39	broad.mit.edu	37	chr6	160199796	160199796	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggagagaatgggcagaagtCgtggtgttgcagccctgtgc	8	9	17	7	1	0	2	0	0	0	2	1	4	0	3	1	3	3	3	1	3	2	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr6:160199796C>T	uc010kjy.2	+	9	1260	c.1129C>T	c.(1129-1131)CGT>TGT	p.R377C	ACAT2_uc011efw.1_Missense_Mutation_p.R406C|TCP1_uc003qsr.2_3'UTR|TCP1_uc003qss.2_3'UTR|TCP1_uc010kjz.2_3'UTR|TCP1_uc003qst.2_3'UTR	NM_005891	NP_005882	Q9BWD1	THIC_HUMAN	acetyl-Coenzyme A acetyltransferase 2	377						mitochondrion|nucleolus	acetyl-CoA C-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.51e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		GGGCAGAAGTCGTGGTGTTGC	0.478													33	108					0	0	0	0	T	160199796	T	T	160199796	3	4	266	1	0	0	0	0	1	0	0	0	122	884	31	1	1163	1	ACAT2	6	160199796	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	42334054	160199796	10915271	39	48428											
TNRC18	84629	broad.mit.edu	37	chr7	5427413	5427413	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagccactgcaatgcccacaGgcgggtgtcgcacttctgcc	7	7	11	16	2	1	0	0	0	1	0	2	0	1	0	3	2	4	2	3	2	1	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr7:5427413G>A	uc003soi.3	-	5	2391	c.2042C>T	c.(2041-2043)CCT>CTT	p.P681L	TNRC18_uc010ksx.1_Missense_Mutation_p.P607L	NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	681							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AATGCCCACAGGCGGGTGTCG	0.701													20	35					0	0	0	0	A	5427413	A	A	5427413	3	1	266	1	0	0	0	0	1	0	0	0	16405	1000	35	4	6968	4	TNRC18	7	5427413	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08		5427413	153711250	40	48429											
TYW1B	441250	broad.mit.edu	37	chr7	72300332	72300332	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcgaaatcgcctgctacaGaaacaaggtcgtcggctggc	10	8	11	12	4	0	1	0	0	0	1	4	2	0	1	1	3	3	2	1	3	4	2	rs2240537	by1000genomes	TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	c609bd55-58d8-47e2-a609-40fb839ef1e8	g.chr7:72300332G>A	uc011kej.1	-						TYW1B_uc011keh.1_5'Flank|TYW1B_uc011kek.1_5'Flank|SBDSP1_uc003twf.2_RNA|SBDSP1_uc011kel.1_RNA|SBDSP1_uc003twg.2_RNA|SBDSP1_uc003twh.2_RNA|SBDSP1_uc003twe.2_RNA	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GCCTGCTACAGAAACAAGGTC	0.652													3	44					0	0	0	0	A	72300332	A	A	72300332	1	1	266	0	1	0	0	0	0	0	0	0	16887	957	33	2		2	TYW1B	7	72300332	5'Flank	SNP	G	TCGA-CV-7434-01A-11D-2129-08	66872919	72300332	86838331	41	48430											
TMEM168	64418	broad.mit.edu	37	chr7	112424255	112424255	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggaaaaaaataacaaaactGcaaaaataactaagtttgga	24	7	6	4	0	0	0	0	0	0	0	0	2	0	2	0	2	4	2	0	2	10	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr7:112424255G>T	uc003vgn.2	-	2	1018	c.626C>A	c.(625-627)GCA>GAA	p.A209E	TMEM168_uc010lju.2_Missense_Mutation_p.A209E|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	209	Helical; (Potential).					integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						TAACAAAACTGCAAAAATAAC	0.333													11	40					6.40141e-05	6.65147e-05	1	0	T	112424255	T	T	112424255	3	4	266	1	0	0	0	0	1	0	0	0	16149	1319	46	4	1483	4	TMEM168	7	112424255	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	40123923	112424255	46714408	42	48431											
CTTNBP2	83992	broad.mit.edu	37	chr7	117351685	117351685	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctatttgccttgtattactgCtgctgctgcttcttttggtg	3	20	9	9	0	1	0	0	0	1	0	1	0	1	0	1	1	6	5	1	1	3	8			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr7:117351685C>T	uc003vjf.2	-	23	4990	c.4898G>A	c.(4897-4899)AGC>AAC	p.S1633N		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1633										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGTATTACTGCTGCTGCTGCT	0.383													4	89					0	0	0	0	T	117351685	T	T	117351685	3	4	266	1	0	0	0	0	1	0	0	0	4062	797	28	4	97	4	CTTNBP2	7	117351685	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	4927430	117351685	41786978	43	48432											
FAM135B	51059	broad.mit.edu	37	chr8	139165127	139165127	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagtatccacatctgccaCtggatatgtcccagcatcag	12	9	8	12	0	2	1	1	0	1	1	4	2	4	2	3	1	2	2	3	1	3	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr8:139165127C>G	uc003yuy.2	-	13	1762	c.1591G>C	c.(1591-1593)GTG>CTG	p.V531L	FAM135B_uc003yux.2_Missense_Mutation_p.V432L|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.V93L|FAM135B_uc003yvb.2_Missense_Mutation_p.V93L	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	531										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACATCTGCCACTGGATATGTC	0.458										HNSCC(54;0.14)			34	125					0	0	0	0	G	139165127	G	G	139165127	3	3	266	1	0	0	0	0	1	0	0	0	5477	565	20	4	2661	4	FAM135B	8	139165127	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08		139165127	7198895	44	48433											
ZNF251	90987	broad.mit.edu	37	chr8	145947838	145947839	+	Frame_Shift_Del	DEL	TC	-	-																															ttcattacatacatagggttTctctccagtatgaacccgat																										TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr8:145947838_145947839delTC	uc003zdv.3	-	5	1462_1463	c.1206_1207delGA	c.(1204-1209)GAGAAAfs	p.E402fs		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	402_403					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		ACATAGGGTTTCTCTCCAGTAT	0.441													---	---	---								-	145947839	-	-	145947838	7	5	266	1	0	1	0	1	0	0	0	0	17863	1792	62	0	812	0	ZNF251	8	145947838	Frame_Shift_Del	DEL	TC	TCGA-CV-7434-01A-11D-2129-08	6782711	145947838	416184	45	48434											
INSL4	3641	broad.mit.edu	37	chr9	5233853	5233853	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtaatttgtgacgatggAacttcagttaaattatgtac	14	14	9	4	1	1	1	1	1	0	0	1	4	1	2	0	1	2	3	0	1	7	6			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr9:5233853A>G	uc003ziy.2	+	2	501	c.396A>G	c.(394-396)GGA>GGG	p.G132G		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	132					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		GTGACGATGGAACTTCAGTTA	0.363													38	99					0	0	0	0	G	5233853	G	G	5233853	2	3	266	1	0	0	0	0	0	0	0	1	7807	233	9	5		5	INSL4	9	5233853	Silent	SNP	A	TCGA-CV-7434-01A-11D-2129-08		5233853	135979578	46	48435											
ZNF510	22869	broad.mit.edu	37	chr9	99522150	99522150	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattatattcctccacagttGacttctcaaaggatttccca	11	15	4	11	0	1	1	1	1	1	0	5	2	4	2	3	1	0	1	3	1	4	7			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr9:99522150G>C	uc004awn.1	-	6	1151	c.962C>G	c.(961-963)TCA>TGA	p.S321*	ZNF510_uc004awo.1_Nonsense_Mutation_p.S321*	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				CTCCACAGTTGACTTCTCAAA	0.358													24	78					0	0	0	0	C	99522150	C	C	99522150	4	2	266	1	0	0	0	0	0	1	0	0	18021	1294	45	2	1093	2	ZNF510	9	99522150	Nonsense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	94288297	99522150	41691281	47	48436											
TEX10	54881	broad.mit.edu	37	chr9	103091488	103091488	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacttcaataacaaagtcCgaactggaaggataaggccc	18	6	8	9	1	1	0	1	0	0	0	2	3	2	2	2	3	3	0	2	3	8	3			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr9:103091488C>A	uc004bas.2	-	7	1774	c.1559G>T	c.(1558-1560)CGG>CTG	p.R520L	TEX10_uc011lvf.1_Missense_Mutation_p.R359L|TEX10_uc011lvg.1_Missense_Mutation_p.R523L	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	520						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TAACAAAGTCCGAACTGGAAG	0.343													52	195					2.81731e-22	3.67355e-22	1	0	A	103091488	A	A	103091488	3	1	266	1	0	0	0	0	1	0	0	0	15838	652	23	3	1266	3	TEX10	9	103091488	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	3569338	103091488	38121943	48	48437											
SH2D3C	10044	broad.mit.edu	37	chr9	130507362	130507362	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagaaggggctgcaggggcGgcatggacacgggttactgc	8	5	19	9	2	0	1	0	0	0	1	0	2	0	2	0	7	3	5	0	7	2	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr9:130507362G>A	uc004bsc.2	-	7	1423	c.1281C>T	c.(1279-1281)GCC>GCT	p.A427A	SH2D3C_uc010mxo.2_Silent_p.A267A|SH2D3C_uc004bry.2_Silent_p.A269A|SH2D3C_uc004brz.3_Silent_p.A73A|SH2D3C_uc011mak.1_Silent_p.A73A|SH2D3C_uc004bsa.2_Silent_p.A270A|SH2D3C_uc004bsb.2_Silent_p.A359A	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	427					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						CTGCAGGGGCGGCATGGACAC	0.622													24	37					0	0	0	0	A	130507362	A	A	130507362	2	1	266	1	0	0	0	0	0	0	0	1	14299	1103	39	1		1	SH2D3C	9	130507362	Silent	SNP	G	TCGA-CV-7434-01A-11D-2129-08	27415874	130507362	10706069	49	48438											
CACNA1B	774	broad.mit.edu	37	chr9	140811748	140811748	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaggccccagcccggctgtgCgagggcgacactgagtgccg	6	4	17	14	4	0	1	0	1	0	0	0	4	0	1	4	3	3	1	4	3	0	0			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr9:140811748C>T	uc004cog.2	+	6	976	c.831C>T	c.(829-831)TGC>TGT	p.C277C		NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	277	I.|Extracellular (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCCGGCTGTGCGAGGGCGACA	0.572													43	54					0	0	0	0	T	140811748	T	T	140811748	2	4	266	1	0	0	0	0	0	0	0	1	2551	776	27	1		1	CACNA1B	9	140811748	Silent	SNP	C	TCGA-CV-7434-01A-11D-2129-08	10304386	140811748	401683	50	48439											
CTNNA3	29119	broad.mit.edu	37	chr10	68139106	68139106	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgacatcttccaagatatgGctttctgtaagtaaatgaat	13	15	7	6	0	2	3	0	2	2	1	3	3	3	3	1	1	0	3	1	1	6	6			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr10:68139106G>T	uc009xpn.1	-	12	1659	c.1536C>A	c.(1534-1536)AGC>AGA	p.S512R	CTNNA3_uc001jmw.2_Missense_Mutation_p.S512R	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	512					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CCAAGATATGGCTTTCTGTAA	0.378													18	40					2.35188e-11	2.81802e-11	1	0	T	68139106	T	T	68139106	3	4	266	1	0	0	0	0	1	0	0	0	4031	1194	42	4	1179	4	CTNNA3	10	68139106	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08		68139106	67395641	51	48440											
DDIT4	54541	broad.mit.edu	37	chr10	74034470	74034470	+	Frame_Shift_Del	DEL	G	-	-																															cagacacggcttacctggatGgggtgtcgttgcccgacttc																										TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr10:74034470delG	uc001jsx.1	+	3	425	c.223delG	c.(223-225)GGGfs	p.G75fs		NM_019058	NP_061931	Q9NX09	DDIT4_HUMAN	RTP801	75					apoptosis					pancreas(1)	1						TTACCTGGATGGGGTGTCGTT	0.587													---	---	---								-	74034470	-	-	74034470	7	5	266	1	0	1	0	1	0	0	0	0	4348	1348	47	0	229	0	DDIT4	10	74034470	Frame_Shift_Del	DEL	G	TCGA-CV-7434-01A-11D-2129-08	5895364	74034470	61500277	52	48441											
CTBP2	1488	broad.mit.edu	37	chr10	126682531	126682531	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccgccacgggctgcgttCacaaggaatgctccctgcct	7	7	12	15	3	1	0	1	0	0	0	2	1	2	1	4	3	3	3	4	3	2	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr10:126682531C>A	uc009yak.2	-	8	1091	c.804G>T	c.(802-804)GTG>GTT	p.V268V	CTBP2_uc009yal.2_Silent_p.V268V|CTBP2_uc001lif.3_Silent_p.V268V|CTBP2_uc001lih.3_Silent_p.V268V|CTBP2_uc001lid.3_Silent_p.V336V|CTBP2_uc001lie.3_Silent_p.V808V	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	268					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GGGCTGCGTTCACAAGGAATG	0.557													40	66					3.4345e-17	4.39219e-17	1	0	A	126682531	A	A	126682531	2	1	266	1	0	0	0	0	0	0	0	1	4015	813	29	2		2	CTBP2	10	126682531	Silent	SNP	C	TCGA-CV-7434-01A-11D-2129-08	52648061	126682531	8852216	53	48442											
OSBPL5	114879	broad.mit.edu	37	chr11	3121473	3121473	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctttgccgtccagcagcgcCgacagcgagttccctgcaga	7	7	12	15	4	0	1	0	0	0	1	2	3	2	1	4	0	5	4	4	0	0	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:3121473C>T	uc001lxk.2	-	14	1694	c.1536G>A	c.(1534-1536)TCG>TCA	p.S512S	OSBPL5_uc010qxq.1_Silent_p.S423S|OSBPL5_uc009ydw.2_Silent_p.S444S|OSBPL5_uc001lxl.2_Silent_p.S444S|OSBPL5_uc009ydx.2_Silent_p.S536S	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	512					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CCAGCAGCGCCGACAGCGAGT	0.607													11	13					0	0	0	0	T	3121473	T	T	3121473	2	4	266	1	0	0	0	0	0	0	0	1	11334	639	23	1		1	OSBPL5	11	3121473	Silent	SNP	C	TCGA-CV-7434-01A-11D-2129-08		3121473	131885043	54	48443											
OR51A4	401666	broad.mit.edu	37	chr11	4968495	4968498	+	5'Flank	DEL	TGGT	-	-																															gctatcatcatgaagagagaTggttggttgctgctttggac																								rs143841512		TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	c609bd55-58d8-47e2-a609-40fb839ef1e8	g.chr11:4968495_4968498delTGGT	uc010qys.1	-							NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAAGAGAGATGGTTGGTTGCTGC	0.304													---	---	---								-	4968498	-	-	4968495	6	5	266	0	1	1	0	1	0	0	0	0	11141	1479	51	0		0	OR51A4	11	4968495	5'Flank	DEL	TGGT	TCGA-CV-7434-01A-11D-2129-08	1847022	4968495	130038021	55	48444											
OR5D14	219436	broad.mit.edu	37	chr11	55563815	55563815	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccatccttttcctttacTgtgtacccaactccaaaaac	11	12	4	14	0	0	0	0	0	0	0	3	1	3	1	5	1	4	1	5	1	5	5			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:55563815T>A	uc010rim.1	+	1	784	c.784T>A	c.(784-786)TGT>AGT	p.C262S		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TTTCCTTTACTGTGTACCCAA	0.488													21	30					0	0	0	0	A	55563815	A	A	55563815	3	1	266	1	0	0	0	0	1	0	0	0	11209	1580	55	5	786	5	OR5D14	11	55563815	Missense_Mutation	SNP	T	TCGA-CV-7434-01A-11D-2129-08	50595320	55563815	79442701	56	48445											
MARK2	2011	broad.mit.edu	37	chr11	63666242	63666242	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtctcttacaggagaggtAtttgattacctagtggctca	9	14	11	7	0	2	2	1	1	1	1	3	3	2	2	1	4	2	2	1	4	4	5			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:63666242A>G	uc001nxw.2	+	6	990	c.411A>G	c.(409-411)GTA>GTG	p.V137V	MARK2_uc001nxx.2_Silent_p.V137V|MARK2_uc001nxy.2_Silent_p.V137V|MARK2_uc001nxv.3_Silent_p.V137V|MARK2_uc001nxz.3_Silent_p.V104V|MARK2_uc009yoy.2_Silent_p.V104V	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	137	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CAGGAGAGGTATTTGATTACC	0.552													17	52					0	0	0	0	G	63666242	G	G	63666242	2	3	266	1	0	0	0	0	0	0	0	1	9366	436	16	5		5	MARK2	11	63666242	Silent	SNP	A	TCGA-CV-7434-01A-11D-2129-08	8102427	63666242	71340274	57	48446											
CPT1A	1374	broad.mit.edu	37	chr11	68552321	68552321	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgccagcctggcctccccGggctgaggctccgaggtatt	4	8	14	15	2	0	1	0	1	0	0	2	2	2	1	6	4	2	4	6	4	1	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:68552321G>A	uc001oog.3	-	10	1295	c.1125C>T	c.(1123-1125)CCC>CCT	p.P375P	CPT1A_uc001oof.3_Silent_p.P375P|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	375	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	TGGCCTCCCCGGGCTGAGGCT	0.642													28	30					0	0	0	0	A	68552321	A	A	68552321	2	1	266	1	0	0	0	0	0	0	0	1	3846	1103	39	1		1	CPT1A	11	68552321	Silent	SNP	G	TCGA-CV-7434-01A-11D-2129-08	4886079	68552321	66454195	58	48447											
GRIA4	2893	broad.mit.edu	37	chr11	105804580	105804580	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcaaatttgcctttctcctgGagtccactatgaatgaatac	11	13	7	10	0	1	2	0	2	1	0	3	3	2	3	3	1	2	1	3	1	5	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:105804580G>T	uc001pix.2	+	14	2625	c.2179G>T	c.(2179-2181)GAG>TAG	p.E727*	GRIA4_uc001piw.2_Nonsense_Mutation_p.E727*|GRIA4_uc010rvm.1_RNA|GRIA4_uc009yxl.1_RNA	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	727	Extracellular (Potential).	Glutamate (By similarity).			glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	CTTTCTCCTGGAGTCCACTAT	0.488													20	31					4.63292e-17	5.86837e-17	1	0	T	105804580	T	T	105804580	4	4	266	1	0	0	0	0	0	1	0	0	6809	1175	41	2	2266	2	GRIA4	11	105804580	Nonsense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	37252259	105804580	29201936	59	48448											
ADAMTS8	11095	broad.mit.edu	37	chr11	130275888	130275888	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcagagatggccaggttgccGttgagcaggtactgcccatc	8	8	14	11	1	0	2	0	1	0	1	1	3	0	2	3	3	4	5	3	3	1	3			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr11:130275888G>A	uc001qgg.3	-	9	2593	c.2235C>T	c.(2233-2235)AAC>AAT	p.N745N	ADAMTS8_uc001qgf.2_Silent_p.N226N	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	745	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CCAGGTTGCCGTTGAGCAGGT	0.597													17	70					0	0	0	0	A	130275888	A	A	130275888	2	1	266	1	0	0	0	0	0	0	0	1	272	1136	40	1		1	ADAMTS8	11	130275888	Silent	SNP	G	TCGA-CV-7434-01A-11D-2129-08	24471308	130275888	4730628	60	48449											
MLL2	8085	broad.mit.edu	37	chr12	49435983	49435983	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagcgctgaagactccgctGgttataggagagtccgtcgc	8	8	13	12	4	0	3	0	1	0	2	3	4	2	3	3	2	1	3	3	2	3	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:49435983G>A	uc001rta.3	-	28	5998	c.5998C>T	c.(5998-6000)CAG>TAG	p.Q2000*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2000					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGACTCCGCTGGTTATAGGAG	0.607			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			7	7					0	0	0	0	A	49435983	A	A	49435983	4	1	266	1	0	0	0	0	0	1	0	0	9674	1357	47	4	10723	4	MLL2	12	49435983	Nonsense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08		49435983	84415912	61	48450											
FMNL3	91010	broad.mit.edu	37	chr12	50044492	50044492	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcagatctcctcagccgagCggccagccttgcgtagggtg	6	8	14	13	3	2	1	1	0	1	1	3	2	2	1	4	2	5	2	4	2	1	2	rs149056505	by1000genomes	TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:50044492C>A	uc001ruv.1	-	17	2201	c.1967G>T	c.(1966-1968)CGC>CTC	p.R656L	FMNL3_uc001ruw.1_Missense_Mutation_p.R605L|FMNL3_uc001rut.1_Missense_Mutation_p.R222L|FMNL3_uc001ruu.1_Missense_Mutation_p.R506L	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	656	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						CTCAGCCGAGCGGCCAGCCTT	0.582													23	32					4.72057e-08	5.23197e-08	1	0	A	50044492	A	A	50044492	3	1	266	1	0	0	0	0	1	0	0	0	5985	768	27	3	1156	3	FMNL3	12	50044492	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	608509	50044492	83807403	62	48451											
DAZAP2	9802	broad.mit.edu	37	chr12	51636287	51636287	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaagacatcacataccttCagcacttctcacaatgtaac	15	9	5	12	0	3	1	3	0	1	1	4	2	3	2	1	1	3	2	1	1	4	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:51636287C>T	uc010snd.1	+	4	659	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	DAZAP2_uc001ryb.2_3'UTR|DAZAP2_uc010snc.1_3'UTR|DAZAP2_uc010sne.1_3'UTR|DAZAP2_uc010snf.1_Intron	NM_001136266	NP_001129738	Q15038	DAZP2_HUMAN	DAZ associated protein 2 isoform c	Error:Variant_position_missing_in_Q15038_after_alignment							WW domain binding				0						CACATACCTTCAGCACTTCTC	0.483													19	46					0	0	0	0	T	51636287	T	T	51636287	4	4	266	1	0	0	0	0	0	1	0	0	4262	827	29	2	566	2	DAZAP2	12	51636287	Nonsense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	1591795	51636287	82215608	63	48452											
NR4A1	3164	broad.mit.edu	37	chr12	52451148	52451148	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgccaggtctaagccaggCgagggcaagctcatcttctg	8	8	12	13	1	4	0	1	0	3	0	4	1	4	0	3	3	3	2	3	3	2	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:52451148C>A	uc001rzs.2	+	7	1688	c.1374C>A	c.(1372-1374)GGC>GGA	p.G458G	NR4A1_uc010sno.1_Silent_p.G471G|NR4A1_uc001rzt.2_Silent_p.G458G|NR4A1_uc009zmc.2_Missense_Mutation_p.A72E	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	458	Ligand-binding (Potential).				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CTAAGCCAGGCGAGGGCAAGC	0.607													17	33					3.41278e-10	3.98158e-10	1	0	A	52451148	A	A	52451148	2	1	266	1	0	0	0	0	0	0	0	1	10686	755	27	3		3	NR4A1	12	52451148	Silent	SNP	C	TCGA-CV-7434-01A-11D-2129-08	814861	52451148	81400747	64	48453											
PA2G4	5036	broad.mit.edu	37	chr12	56506656	56506656	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggggaaacattagaagaaaAtgaagctggggactgaggtg	15	7	16	3	0	0	4	0	2	0	2	0	6	0	6	0	5	2	1	0	5	6	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:56506656A>G	uc001sjm.2	+	13	1588	c.1169A>G	c.(1168-1170)AAT>AGT	p.N390S	PA2G4_uc009zol.2_Missense_Mutation_p.N372S|PA2G4_uc009zom.2_3'UTR	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	390	Necessary for nucleolar localization.				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			TTAGAAGAAAATGAAGCTGGG	0.517													27	65					0	0	0	0	G	56506656	G	G	56506656	3	3	266	1	0	0	0	0	1	0	0	0	11415	101	4	5	1219	5	PA2G4	12	56506656	Missense_Mutation	SNP	A	TCGA-CV-7434-01A-11D-2129-08	4055508	56506656	77345239	65	48454											
RAB21	23011	broad.mit.edu	37	chr12	72176380	72176380	+	Nonsense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtgggagcaaaacattaTcatacttcagccaaacagaa	16	9	7	9	0	3	1	2	0	1	1	3	2	3	2	1	1	5	1	1	1	6	3			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:72176380T>G	uc001swt.2	+	6	729	c.477T>G	c.(475-477)TAT>TAG	p.Y159*		NM_014999	NP_055814	Q9UL25	RAB21_HUMAN	RAB21, member RAS oncogene family	159					protein transport|small GTPase mediated signal transduction	cleavage furrow|cytoplasmic vesicle membrane|early endosome membrane|endoplasmic reticulum membrane|Golgi membrane	GDP binding|GTP binding|GTPase activity|protein binding				0						CAAAACATTATCATACTTCAG	0.303													10	22					0	0	0	0	G	72176380	G	G	72176380	4	3	266	1	0	0	0	0	0	1	0	0	12973	1442	50	5	499	5	RAB21	12	72176380	Nonsense_Mutation	SNP	T	TCGA-CV-7434-01A-11D-2129-08	15669724	72176380	61675515	66	48455											
ACSS3	79611	broad.mit.edu	37	chr12	81545669	81545669	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctgtcatgctacactggtCaatgtcttccatatacggac	9	12	8	12	2	3	0	2	0	1	0	4	1	4	1	1	2	3	2	1	2	4	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:81545669C>A	uc001szl.1	+	6	1059	c.968C>A	c.(967-969)TCA>TAA	p.S323*	ACSS3_uc001szm.1_Nonsense_Mutation_p.S322*|ACSS3_uc001szn.1_Nonsense_Mutation_p.S5*	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	323						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CTACACTGGTCAATGTCTTCC	0.343													19	45					5.26018e-13	6.53835e-13	1	0	A	81545669	A	A	81545669	4	1	266	1	0	0	0	0	0	1	0	0	190	838	29	2	990	2	ACSS3	12	81545669	Nonsense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	9369289	81545669	52306226	67	48456											
CMKLR1	1240	broad.mit.edu	37	chr12	108686279	108686279	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggccatgtaagccaggCgaacgctgcggtggttctgg	7	8	16	10	3	1	0	0	0	1	0	1	1	1	0	2	5	4	4	2	5	2	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr12:108686279C>T	uc009zuw.2	-	3	652	c.461G>A	c.(460-462)CGC>CAC	p.R154H	CMKLR1_uc001tmw.2_Missense_Mutation_p.R154H|CMKLR1_uc001tmv.2_Missense_Mutation_p.R152H|CMKLR1_uc009zuv.2_Missense_Mutation_p.R154H	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	154	Cytoplasmic (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						GTAAGCCAGGCGAACGCTGCG	0.562													10	38					0	0	0	0	T	108686279	T	T	108686279	3	4	266	1	0	0	0	0	1	0	0	0	3594	768	27	1	664	1	CMKLR1	12	108686279	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	27140610	108686279	25165616	68	48457											
TPTE2	93492	broad.mit.edu	37	chr13	20025355	20025355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtttcttatctagaaacCgcacaacttcctaaaaaaga	16	11	5	9	1	2	2	0	0	2	2	3	3	3	2	2	0	2	2	2	0	7	5			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr13:20025355C>T	uc001umd.2	-	12	963	c.752G>A	c.(751-753)CGG>CAG	p.R251Q	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.R140Q|TPTE2_uc001ume.2_Missense_Mutation_p.R174Q|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	251	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ATCTAGAAACCGCACAACTTC	0.338													20	41					0	0	0	0	T	20025355	T	T	20025355	3	4	266	1	0	0	0	0	1	0	0	0	16498	652	23	1	856	1	TPTE2	13	20025355	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08		20025355	95144523	69	48458											
PCDH9	5101	broad.mit.edu	37	chr13	67802486	67802486	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaggcaattcctctctaatAgtgtaaataagttcttgagc	12	14	7	8	0	3	1	1	1	2	0	5	1	4	1	1	1	1	3	1	1	6	7			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr13:67802486A>T	uc001vik.2	-	2	779	c.87T>A	c.(85-87)ACT>ACA	p.T29T	PCDH9_uc001vil.2_Silent_p.T29T|PCDH9_uc010thl.1_Silent_p.T29T|PCDH9_uc001vin.3_Silent_p.T29T	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	29	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CCTCTCTAATAGTGTAAATAA	0.433													27	42					0	0	0	0	T	67802486	T	T	67802486	2	4	266	1	0	0	0	0	0	0	0	1	11572	407	15	5		5	PCDH9	13	67802486	Silent	SNP	A	TCGA-CV-7434-01A-11D-2129-08	47777131	67802486	47367392	70	48459											
TPP2	7174	broad.mit.edu	37	chr13	103271177	103271177	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatatgactgcttggtatggCatgatggcgaagtctggagg	9	12	15	5	1	1	2	0	2	1	0	1	4	1	3	0	5	1	3	0	5	4	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr13:103271177C>T	uc001vpi.3	+	5	704	c.601C>T	c.(601-603)CAT>TAT	p.H201Y		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	201					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTTGGTATGGCATGATGGCGA	0.368													29	85					0	0	0	0	T	103271177	T	T	103271177	3	4	266	1	0	0	0	0	1	0	0	0	16479	710	25	4	619	4	TPP2	13	103271177	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	35468691	103271177	11898701	71	48460											
SEC23A	10484	broad.mit.edu	37	chr14	39509955	39509955	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggctgcctccatgttcaGtgtcaatgtatcttggcatt	6	15	9	11	0	3	0	2	0	1	0	4	0	4	0	3	2	1	4	3	2	2	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr14:39509955G>A	uc001wup.1	-	18	2346	c.2123C>T	c.(2122-2124)ACT>ATT	p.T708I	SEC23A_uc010tqa.1_Missense_Mutation_p.T594I|SEC23A_uc010tqb.1_Missense_Mutation_p.T679I	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	708					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		TCCATGTTCAGTGTCAATGTA	0.428													83	84					0	0	0	0	A	39509955	A	A	39509955	3	1	266	1	0	0	0	0	1	0	0	0	14056	1029	36	4	186	4	SEC23A	14	39509955	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08		39509955	67839585	72	48461											
SOS2	6655	broad.mit.edu	37	chr14	50597308	50597308	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggtgtatttggagaggttGgtgctgacactgttgattcc	7	15	14	5	0	0	3	0	2	0	1	1	4	1	3	1	4	1	4	1	4	1	5			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr14:50597308G>T	uc001wxs.3	-	20	3346	c.3248C>A	c.(3247-3249)CCA>CAA	p.P1083Q	SOS2_uc010ans.2_5'UTR|SOS2_uc010tql.1_Missense_Mutation_p.P1050Q	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1083					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					TGGAGAGGTTGGTGCTGACAC	0.423													65	83					1.32218e-49	1.74108e-49	1	0	T	50597308	T	T	50597308	3	4	266	1	0	0	0	0	1	0	0	0	15001	1348	47	4	766	4	SOS2	14	50597308	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	11087353	50597308	56752232	73	48462											
ZC3H14	79882	broad.mit.edu	37	chr14	89063145	89063145	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggcagaaactctgcagatGagtcaaggttggtaatgttt	12	12	12	5	0	2	3	1	1	1	2	2	3	2	3	0	3	2	5	0	3	3	3			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr14:89063145G>A	uc001xww.2	+	10	1572	c.1347G>A	c.(1345-1347)ATG>ATA	p.M449I	ZC3H14_uc010twd.1_Missense_Mutation_p.M449I|ZC3H14_uc010twe.1_Missense_Mutation_p.M449I|ZC3H14_uc001xwx.2_Intron|ZC3H14_uc010twf.1_Missense_Mutation_p.M294I|ZC3H14_uc001xwy.2_Missense_Mutation_p.M415I|ZC3H14_uc010twg.1_Intron|ZC3H14_uc001xxa.2_Intron|ZC3H14_uc001xxc.2_Intron|ZC3H14_uc001xxb.2_Missense_Mutation_p.M151I	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	449						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						CTCTGCAGATGAGTCAAGGTT	0.383													23	56					0	0	0	0	A	89063145	A	A	89063145	3	1	266	1	0	0	0	0	1	0	0	0	17633	1290	45	2	1774	2	ZC3H14	14	89063145	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	38465837	89063145	18286395	74	48463											
TTC7B	145567	broad.mit.edu	37	chr14	91007854	91007854	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcccgttccagacctcgtggGctgtcgagttcacctgcacc	5	9	11	16	3	1	1	1	0	0	1	4	2	2	1	5	1	1	4	5	1	0	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr14:91007854G>T	uc001xyp.2	-	20	2512	c.2390C>A	c.(2389-2391)GCC>GAC	p.A797D	TTC7B_uc001xyo.2_Missense_Mutation_p.A241D|TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	797	TPR 10.						binding			ovary(2)	2		Melanoma(154;0.222)				GACCTCGTGGGCTGTCGAGTT	0.647													12	42					1.5842e-08	1.77058e-08	1	0	T	91007854	T	T	91007854	3	4	266	1	0	0	0	0	1	0	0	0	16781	1203	42	4	145	4	TTC7B	14	91007854	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	1944709	91007854	16341686	75	48464											
PLA2G4E	123745	broad.mit.edu	37	chr15	42292147	42292147	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcacctgaccatcggaaaGgcagtcgaggggctggctga	10	6	14	11	2	1	2	1	2	0	0	3	4	1	3	2	5	0	3	2	5	1	0			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr15:42292147G>A	uc001zow.1	-	8	817	c.817C>T	c.(817-819)CTT>TTT	p.L273F	PLA2G4E_uc010udc.1_5'Flank|PLA2G4E_uc001zov.1_5'Flank	NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	295					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		CCATCGGAAAGGCAGTCGAGG	0.642													4	6					0	0	0	0	A	42292147	A	A	42292147	3	1	266	1	0	0	0	0	1	0	0	0	12060	1000	35	4	1750	4	PLA2G4E	15	42292147	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08		42292147	60239245	76	48465											
STRA6	64220	broad.mit.edu	37	chr15	74490148	74490148	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtggtatgctggtgtggcagGagggcacttccctgcagagc	6	9	17	9	0	0	1	0	0	0	1	1	2	1	2	1	5	3	5	1	5	1	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr15:74490148G>A	uc002axk.2	-	3	307	c.125C>T	c.(124-126)TCC>TTC	p.S42F	STRA6_uc002axi.2_5'Flank|STRA6_uc010ulh.1_Missense_Mutation_p.S80F|STRA6_uc002axj.2_Missense_Mutation_p.S81F|STRA6_uc010bji.2_Missense_Mutation_p.S42F|STRA6_uc002axl.2_5'UTR|STRA6_uc002axm.2_Missense_Mutation_p.S42F|STRA6_uc002axn.2_Missense_Mutation_p.S42F|STRA6_uc010uli.1_Missense_Mutation_p.S79F|STRA6_uc010bjj.1_RNA|STRA6_uc010bjk.2_Missense_Mutation_p.S42F	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	42	Extracellular (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						GGTGTGGCAGGAGGGCACTTC	0.622													3	25					0	0	0	0	A	74490148	A	A	74490148	3	1	266	1	0	0	0	0	1	0	0	0	15388	1174	41	2	1996	2	STRA6	15	74490148	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	32198001	74490148	28041244	77	48466											
CREBBP	1387	broad.mit.edu	37	chr16	3788645	3788646	+	Missense_Mutation	DNP	TA	AC	AC																															acgtggccggaagaaatgaaTactatccagataagaaatgt																										TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr16:3788645_3788646TA>AC	uc002cvv.2	-	26	4512_4513	c.4308_4309TA>GT	c.(4306-4311)AGTATT>AGGTTT	p.1436_1437SI>RF	CREBBP_uc002cvw.2_Missense_Mutation_p.1398_1399SI>RF	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1436_1437	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AAGAAATGAATACTATCCAGAT	0.416			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				3	19					0	0	0	0	AC	3788646	AC	AC	3788645	3	1	266	1	0	0	0	0	1	0	0	0	3876	1406	49	5	3043	5	CREBBP	16	3788645	Missense_Mutation	DNP	TA	TCGA-CV-7434-01A-11D-2129-08		3788645	86566108	78	48467											
ERCC4	2072	broad.mit.edu	37	chr16	14029437	14029437	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctttcggaatcctgaaagaaCccctcactatcatccatccg	11	10	5	15	2	2	2	2	1	0	1	6	3	5	3	5	1	1	0	5	1	4	2	rs139197943		TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr16:14029437C>T	uc002dce.2	+	8	1657	c.1648C>T	c.(1648-1650)CCC>TCC	p.P550S	ERCC4_uc010uyz.1_Missense_Mutation_p.P100S	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	550					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						CCTGAAAGAACCCCTCACTAT	0.463			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				22	53					0	0	0	0	T	14029437	T	T	14029437	3	4	266	1	0	0	0	0	1	0	0	0	5239	507	18	4	1678	4	ERCC4	16	14029437	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	10240792	14029437	76325316	79	48468											
ACSM2B	348158	broad.mit.edu	37	chr16	20570579	20570579	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctcgaatgcagcccaggAtcaccagccaccactcaggc	10	5	9	17	1	2	0	2	0	0	0	3	2	2	1	4	2	4	2	4	2	1	0			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr16:20570579A>G	uc002dhj.3	-	4	578	c.368T>C	c.(367-369)ATC>ACC	p.I123T	ACSM2B_uc002dhk.3_Missense_Mutation_p.I123T|ACSM2B_uc010bwf.1_Missense_Mutation_p.I123T	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	123					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GCAGCCCAGGATCACCAGCCA	0.577													8	17					0	0	0	0	G	20570579	G	G	20570579	3	3	266	1	0	0	0	0	1	0	0	0	184	333	12	5	1413	5	ACSM2B	16	20570579	Missense_Mutation	SNP	A	TCGA-CV-7434-01A-11D-2129-08	6541142	20570579	69784174	80	48469											
CLN3	1201	broad.mit.edu	37	chr16	28497943	28497943	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggaaggtgacctccccaagGcctgatgagatgctagcgaa	12	6	13	10	1	0	3	0	3	0	1	1	6	1	4	4	3	2	1	4	3	4	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr16:28497943G>A	uc002dpo.2	-	7	812	c.489C>T	c.(487-489)GGC>GGT	p.G163G	uc010vct.1_Intron|CLN3_uc002dpl.2_Silent_p.G85G|CLN3_uc010vcu.1_Silent_p.G63G|CLN3_uc002dpn.2_Intron|CLN3_uc002dpm.2_Silent_p.G109G|CLN3_uc010vcv.1_Silent_p.G139G|CLN3_uc010byd.2_Silent_p.G163G|CLN3_uc002dpp.2_Silent_p.G163G|CLN3_uc002dpt.1_Silent_p.G63G|CLN3_uc002dpq.1_Silent_p.G163G|CLN3_uc010bye.1_Silent_p.G163G|CLN3_uc002dpr.1_Intron|CLN3_uc010byf.1_Intron|CLN3_uc002dps.1_Intron|CLN3_uc002dpu.1_Silent_p.G109G|CLN3_uc002dpw.1_Intron|CLN3_uc010vcw.1_Silent_p.G109G|CLN3_uc002dqa.2_Silent_p.G214G|CLN3_uc010vcx.1_Silent_p.G63G|CLN3_uc002dpx.1_Intron|CLN3_uc002dpy.1_Intron|CLN3_uc002dpz.1_RNA	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	163					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						CCTCCCCAAGGCCTGATGAGA	0.607													3	9					0	0	0	0	A	28497943	A	A	28497943	2	1	266	1	0	0	0	0	0	0	0	1	3558	1190	42	4		4	CLN3	16	28497943	Silent	SNP	G	TCGA-CV-7434-01A-11D-2129-08	7927364	28497943	61856810	81	48470											
CENPBD1	92806	broad.mit.edu	37	chr16	90038291	90038291	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttccgttcccttttggcacTagggatgacagttgcatctg	6	15	10	10	1	1	1	0	1	1	0	3	2	3	2	2	2	1	4	2	2	1	6			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr16:90038291T>G	uc002fpr.2	-	1	652	c.40A>C	c.(40-42)AGT>CGT	p.S14R	AFG3L1_uc002fps.1_5'Flank|AFG3L1_uc002fpt.1_5'Flank|AFG3L1_uc002fpu.1_5'Flank|AFG3L1_uc002fpv.1_5'Flank|AFG3L1_uc002fpw.1_5'Flank|AFG3L1_uc002fpx.1_5'Flank	NM_145039	NP_659476	B2RD01	CENP1_HUMAN	CENPB DNA-binding domains containing 1	14	HTH psq-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CTTTTGGCACTAGGGATGACA	0.502													9	23					0	0	0	0	G	90038291	G	G	90038291	3	3	266	1	0	0	0	0	1	0	0	0	3243	1522	53	5	527	5	CENPBD1	16	90038291	Missense_Mutation	SNP	T	TCGA-CV-7434-01A-11D-2129-08	61540348	90038291	316462	82	48471											
ACADVL	37	broad.mit.edu	37	chr17	7124963	7124963	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcctgctctttggcacaaAggcccagaaagaaaaatacc	15	7	7	12	0	1	2	0	0	1	2	2	2	2	2	3	2	2	2	3	2	5	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr17:7124963A>G	uc002gev.2	+	7	735	c.584A>G	c.(583-585)AAG>AGG	p.K195R	DLG4_uc002get.3_5'Flank|DLG4_uc010vto.1_5'Flank|ACADVL_uc010vtp.1_Missense_Mutation_p.K205R|ACADVL_uc010vtq.1_Missense_Mutation_p.K241R|ACADVL_uc002gew.2_Missense_Mutation_p.K173R|ACADVL_uc002gex.2_Missense_Mutation_p.K119R	NM_000018	NP_000009	P49748	ACADV_HUMAN	acyl-Coenzyme A dehydrogenase, very long chain	195	Catalytic.				energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			ovary(3)	3						TTTGGCACAAAGGCCCAGAAA	0.577													27	57					0	0	0	0	G	7124963	G	G	7124963	3	3	266	1	0	0	0	0	1	0	0	0	116	72	3	5	610	5	ACADVL	17	7124963	Missense_Mutation	SNP	A	TCGA-CV-7434-01A-11D-2129-08		7124963	74070247	83	48472											
TP53	7157	broad.mit.edu	37	chr17	7578527	7578527	+	Frame_Shift_Del	DEL	A	-	-																															gcaggtcttggccagttggcAaaacatcttgttgagggcag																										TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr17:7578527delA	uc002gim.2	-	5	597	c.403delT	c.(403-405)TGCfs	p.C135fs	TP53_uc002gig.1_Frame_Shift_Del_p.C135fs|TP53_uc002gih.2_Frame_Shift_Del_p.C135fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.C3fs|TP53_uc010cng.1_Frame_Shift_Del_p.C3fs|TP53_uc002gii.1_Frame_Shift_Del_p.C3fs|TP53_uc010cnh.1_Frame_Shift_Del_p.C135fs|TP53_uc010cni.1_Frame_Shift_Del_p.C135fs|TP53_uc002gij.2_Frame_Shift_Del_p.C135fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.C42fs|TP53_uc002gio.2_Frame_Shift_Del_p.C3fs|TP53_uc010vug.1_Frame_Shift_Del_p.C96fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	135	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation; decreased E6-mediated binding to E6-AP).|C -> T (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C135Y(49)|p.C135F(34)|p.C135W(19)|p.C135S(10)|p.C135fs*35(9)|p.0?(7)|p.C135*(7)|p.C135G(6)|p.C135R(6)|p.C135C(5)|p.C135fs*14(2)|p.N131fs*27(2)|p.F134_T140>S(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.C135T(1)|p.V73fs*9(1)|p.C135fs*36(1)|p.C135fs*15(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.M133fs*13(1)|p.C135_T140delCQLAKT(1)|p.C135_Q136insXXXXXX(1)|p.C135_Q136insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCAGTTGGCAAAACATCTTG	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578527	-	-	7578527	7	5	266	1	0	1	0	1	0	0	0	0	16448	130	5	0	895	0	TP53	17	7578527	Frame_Shift_Del	DEL	A	TCGA-CV-7434-01A-11D-2129-08	453564	7578527	73616683	84	48473											
RAB5C	5878	broad.mit.edu	37	chr17	40282496	40282496	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagctggtccattgggtcGtgctgcgcctccccgacccg	4	8	13	16	4	0	0	0	0	0	0	3	1	2	0	5	2	4	3	5	2	0	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr17:40282496G>A	uc002hyz.2	-	3	342	c.25C>T	c.(25-27)CGA>TGA	p.R9*	RAB5C_uc002hza.2_Nonsense_Mutation_p.R9*|RAB5C_uc010cxx.2_Nonsense_Mutation_p.R42*|RAB5C_uc010cxy.2_Intron	NM_201434	NP_958842	P51148	RAB5C_HUMAN	RAB5C, member RAS oncogene family isoform a	9					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GTP binding|GTPase activity|protein binding			large_intestine(1)|skin(1)	2		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		CCATTGGGTCGTGCTGCGCCT	0.602													11	19					0	0	0	0	A	40282496	A	A	40282496	4	1	266	1	0	0	0	0	0	1	0	0	13015	1153	40	1	645	1	RAB5C	17	40282496	Nonsense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	32703969	40282496	40912714	85	48474											
MGAT5B	146664	broad.mit.edu	37	chr17	74944756	74944756	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacagcaccgagtcggagAtgaaccacctgtacccggcg	10	5	13	13	4	0	3	0	2	0	1	1	5	0	3	4	2	3	2	4	2	2	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr17:74944756A>T	uc002jti.2	+	16	2345	c.2242A>T	c.(2242-2244)ATG>TTG	p.M748L	MGAT5B_uc002jth.2_Missense_Mutation_p.M737L|MGAT5B_uc002jtj.2_Missense_Mutation_p.M144L	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	739	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						CGAGTCGGAGATGAACCACCT	0.652													4	9					0	0	0	0	T	74944756	T	T	74944756	3	4	266	1	0	0	0	0	1	0	0	0	9602	333	12	5	2376	5	MGAT5B	17	74944756	Missense_Mutation	SNP	A	TCGA-CV-7434-01A-11D-2129-08	34662260	74944756	6250454	86	48475											
CDH2	1000	broad.mit.edu	37	chr18	25593761	25593761	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacttggcatgctcagaagaGagtggaaagcttctcacggc	12	8	12	9	1	2	2	2	0	1	2	3	4	2	3	0	3	3	3	0	3	3	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr18:25593761G>C	uc002kwg.2	-	3	744	c.285C>G	c.(283-285)CTC>CTG	p.L95L	CDH2_uc010xbn.1_Silent_p.L64L	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	95					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GCTCAGAAGAGAGTGGAAAGC	0.448													24	21					0	0	0	0	C	25593761	C	C	25593761	2	2	266	1	0	0	0	0	0	0	0	1	3120	929	33	2		2	CDH2	18	25593761	Silent	SNP	G	TCGA-CV-7434-01A-11D-2129-08		25593761	52483487	87	48476											
CCDC159	126075	broad.mit.edu	37	chr19	11464486	11464488	+	Missense_Mutation	TNP	GCA	TAT	TAT																															aggtctgctgtgcacgtgctGcagaactccatagacagcct																										TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:11464486_11464488GCA>TAT	uc010xlw.1	+	10	1036_1038	c.957_959GCA>TAT	c.(955-960)CTGCAG>CTTATG	p.Q320M	CCDC159_uc010xlt.1_Missense_Mutation_p.Q237M|LPPR2_uc002mre.1_5'Flank|LPPR2_uc002mrf.1_5'Flank	NM_001080503	NP_001073972	P0C7I6	CC159_HUMAN	coiled-coil domain-containing-like	352										ovary(1)	1						TGCACGTGCTGCAGAACTCCATA	0.601													4	7					0	0	0	0	TAT	11464488	TAT	TAT	11464486	3	4	266	1	0	0	0	0	1	0	0	0	2804	1306	46	4	742	4	CCDC159	19	11464486	Missense_Mutation	TNP	GCA	TCGA-CV-7434-01A-11D-2129-08		11464486	47664497	88	48477											
ZNF333	84449	broad.mit.edu	37	chr19	14805946	14805946	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caggaccctggcctccagggGtaaggctggcgtcacctggc	6	6	15	14	1	1	0	1	0	0	0	2	1	2	1	4	7	0	2	4	7	1	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:14805946G>A	uc002mzn.2	+	3	261	c.127_splice	c.e3+1	p.G43_splice	ZNF333_uc010dzq.2_Splice_Site_p.G43_splice|ZNF333_uc002mzk.3_Splice_Site|ZNF333_uc002mzl.3_Splice_Site_p.G43_splice|ZNF333_uc002mzm.2_Splice_Site_p.G43_splice|ZNF333_uc010dzr.1_Splice_Site	NM_032433	NP_115809	Q96JL9	ZN333_HUMAN	zinc finger protein 333						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCCTCCAGGGGTAAGGCTGGC	0.582													13	26					0	0	0	0	A	14805946	A	A	14805946	5	1	266	1	0	0	0	0	0	0	1	0	17917	1275	44	4	134	4	ZNF333	19	14805946	Splice_Site	SNP	G	TCGA-CV-7434-01A-11D-2129-08	3341460	14805946	44323037	89	48478											
JAK3	3718	broad.mit.edu	37	chr19	17941381	17941381	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgaccccgaagctccagacGtctgactggcgagagaagat	12	5	12	12	4	1	4	0	1	1	3	2	8	2	4	3	1	1	1	3	1	2	0			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:17941381G>A	uc002nhn.3	-	22	3127	c.3027C>T	c.(3025-3027)GAC>GAT	p.D1009D	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Silent_p.D1009D	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	1009	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						AGCTCCAGACGTCTGACTGGC	0.597		2	Mis		acute megakaryocytic leukemia|								18	24					0	0	0	0	A	17941381	A	A	17941381	2	1	266	1	0	0	0	0	0	0	0	1	7978	1136	40	1		1	JAK3	19	17941381	Silent	SNP	G	TCGA-CV-7434-01A-11D-2129-08	3135435	17941381	41187602	90	48479											
ZNF546	339327	broad.mit.edu	37	chr19	40520277	40520277	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtttgtggcaagacctttaGggtacaacgacatattagtc	11	12	11	7	1	0	1	0	0	0	1	1	2	0	1	1	3	2	3	1	3	6	6			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:40520277G>A	uc002oms.2	+	7	1356	c.1100G>A	c.(1099-1101)AGG>AAG	p.R367K	ZNF546_uc002omt.2_Missense_Mutation_p.R341K	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	367	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AAGACCTTTAGGGTACAACGA	0.388													18	35					0	0	0	0	A	40520277	A	A	40520277	3	1	266	1	0	0	0	0	1	0	0	0	18045	1000	35	4	1118	4	ZNF546	19	40520277	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	22578896	40520277	18608706	91	48480											
PSG8	440533	broad.mit.edu	37	chr19	43268311	43268311	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgtaccagatgtagccagTaagattctggggcaaattgt	11	13	11	6	0	1	2	0	0	1	2	1	2	1	2	2	2	2	4	2	2	4	6			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:43268311T>C	uc002ouo.2	-	2	285	c.187A>G	c.(187-189)ACT>GCT	p.T63A	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Missense_Mutation_p.T63A|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_5'UTR|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Missense_Mutation_p.T63A|PSG8_uc002oum.3_Missense_Mutation_p.T63A|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.T63A	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	63	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				ATGTAGCCAGTAAGATTCTGG	0.458													90	197					0	0	0	0	C	43268311	C	C	43268311	3	2	266	1	0	0	0	0	1	0	0	0	12723	1638	57	5	1130	5	PSG8	19	43268311	Missense_Mutation	SNP	T	TCGA-CV-7434-01A-11D-2129-08	2748034	43268311	15860672	92	48481											
AP2A1	160	broad.mit.edu	37	chr19	50302996	50302996	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgctgcggtacctggagacGgcagactacgccatccgcga	9	6	13	13	5	0	2	0	0	0	2	1	4	1	2	3	3	4	3	3	3	2	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:50302996G>A	uc002ppn.2	+	10	1456	c.1245G>A	c.(1243-1245)ACG>ACA	p.T415T	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Silent_p.T415T|AP2A1_uc002ppp.1_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	415					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		ACCTGGAGACGGCAGACTACG	0.438													9	18					0	0	0	0	A	50302996	A	A	50302996	2	1	266	1	0	0	0	0	0	0	0	1	739	1103	39	1		1	AP2A1	19	50302996	Silent	SNP	G	TCGA-CV-7434-01A-11D-2129-08	7034685	50302996	8825987	93	48482											
SIGLEC10	89790	broad.mit.edu	37	chr19	51914599	51914599	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtccgaggactgtttggTgtggctttctgattccgctt	3	15	15	8	2	1	1	0	1	1	0	3	3	3	2	2	5	0	3	2	5	0	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:51914599T>C	uc002pwo.2	-	11	2464	c.1848A>G	c.(1846-1848)ACA>ACG	p.T616T	SIGLEC10_uc002pwp.2_Silent_p.T558T|SIGLEC10_uc002pwq.2_Silent_p.T463T|SIGLEC10_uc002pwr.2_Silent_p.T521T|SIGLEC10_uc010ycy.1_Silent_p.T431T|SIGLEC10_uc010ycz.1_Silent_p.T473T|SIGLEC10_uc010eow.2_Silent_p.T333T	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	616	Cytoplasmic (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GACTGTTTGGTGTGGCTTTCT	0.398													27	52					0	0	0	0	C	51914599	C	C	51914599	2	2	266	1	0	0	0	0	0	0	0	1	14371	1683	59	5		5	SIGLEC10	19	51914599	Silent	SNP	T	TCGA-CV-7434-01A-11D-2129-08	1611603	51914599	7214384	94	48483											
KIR3DL3	115653	broad.mit.edu	37	chr19	55239225	55239225	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaccccttgcgcctcgtTggacagctccacgatgcggg	6	7	14	14	4	0	0	0	0	0	0	2	4	1	2	4	3	3	2	4	3	0	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:55239225T>C	uc002qgu.1	+	4	522	c.504T>C	c.(502-504)GTT>GTC	p.V168V	KIR2DL3_uc002qgv.2_Intron	NM_153443	NP_703144	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three	168	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		TGCGCCTCGTTGGACAGCTCC	0.557													4	71					0	0	0	0	C	55239225	C	C	55239225	2	2	266	1	0	0	0	0	0	0	0	1	8361	1799	63	5		5	KIR3DL3	19	55239225	Silent	SNP	T	TCGA-CV-7434-01A-11D-2129-08	3324626	55239225	3889758	95	48484											
ZNF671	79891	broad.mit.edu	37	chr19	58232346	58232346	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcccacatttgccacactGatagagtctttcacccgtgt	8	14	6	13	1	2	2	1	1	1	1	3	2	3	2	3	0	1	0	3	0	1	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr19:58232346G>T	uc002qpz.3	-	4	1207	c.1108C>A	c.(1108-1110)CAG>AAG	p.Q370K	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Missense_Mutation_p.Q293K|ZNF671_uc010yhf.1_Missense_Mutation_p.Q272K	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	370	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TTGCCACACTGATAGAGTCTT	0.473													18	34					5.01169e-05	5.24847e-05	1	0	T	58232346	T	T	58232346	3	4	266	1	0	0	0	0	1	0	0	0	18145	1299	45	2	500	2	ZNF671	19	58232346	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	2993121	58232346	896637	96	48485											
CSNK2A1	1457	broad.mit.edu	37	chr20	468128	468128	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgtgactggtggtcatatcGcagcagtttgtccaggaaat	9	11	12	9	2	1	1	1	1	0	0	3	2	2	2	2	3	1	3	2	3	2	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:468128G>A	uc002wdw.1	-	12	1309	c.916C>T	c.(916-918)CGA>TGA	p.R306*	CSNK2A1_uc002wdx.1_Nonsense_Mutation_p.R306*|CSNK2A1_uc002wdy.1_Nonsense_Mutation_p.R170*	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	306	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			TGGTCATATCGCAGCAGTTTG	0.527													39	68					0	0	0	0	A	468128	A	A	468128	4	1	266	1	0	0	0	0	0	1	0	0	3974	1095	38	1	271	1	CSNK2A1	20	468128	Nonsense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08		468128	62557392	97	48486											
ISM1	140862	broad.mit.edu	37	chr20	13279750	13279750	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatcaagcgcaaggacttcCgctggaaggacgccagcggg	10	4	15	12	4	1	0	1	0	0	0	2	3	2	3	2	4	2	3	2	4	3	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:13279750C>T	uc010gce.1	+	6	1045	c.1039C>T	c.(1039-1041)CGC>TGC	p.R347C	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	347	AMOP.					extracellular region					0						CAAGGACTTCCGCTGGAAGGA	0.627													4	26					0	0	0	0	T	13279750	T	T	13279750	3	4	266	1	0	0	0	0	1	0	0	0	7899	652	23	1	1061	1	ISM1	20	13279750	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	12811622	13279750	49745770	98	48487											
VSX1	30813	broad.mit.edu	37	chr20	25057052	25057052	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagccattctcagggctcaCtttatctgagcctctctgtg	7	13	8	13	0	4	1	2	1	3	0	6	1	4	1	2	1	2	1	2	1	2	3			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:25057052C>A	uc002wuf.2	-	5	978	c.943G>T	c.(943-945)GTG>TTG	p.V315L	VSX1_uc002wue.2_Intron|VSX1_uc010gdd.1_Intron|VSX1_uc010gde.1_Intron|VSX1_uc010gdf.1_Intron	NM_014588	NP_055403	Q9NZR4	VSX1_HUMAN	visual system homeobox 1 isoform a	315					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCAGGGCTCACTTTATCTGAG	0.547													37	53					5.73237e-09	6.51628e-09	1	0	A	25057052	A	A	25057052	3	1	266	1	0	0	0	0	1	0	0	0	17299	565	20	4	158	4	VSX1	20	25057052	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	11777302	25057052	37968468	99	48488											
PHF20	51230	broad.mit.edu	37	chr20	34389470	34389470	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcatccacctaacagacGaggaatcagctttgaagtgg	15	7	10	9	1	1	2	1	1	0	1	2	4	2	3	2	2	3	2	2	2	4	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:34389470G>T	uc002xek.1	+	2	137	c.26G>T	c.(25-27)CGA>CTA	p.R9L	PHF20_uc002xei.1_Missense_Mutation_p.R9L|PHF20_uc010gfo.1_Missense_Mutation_p.R9L|PHF20_uc002xej.1_5'UTR|PHF20_uc002xeh.2_RNA	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CCTAACAGACGAGGAATCAGC	0.408													15	37					1.5739e-10	1.869e-10	1	0	T	34389470	T	T	34389470	3	4	266	1	0	0	0	0	1	0	0	0	11886	1058	37	3	28	3	PHF20	20	34389470	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	9332418	34389470	28636050	100	48489											
PTPRT	11122	broad.mit.edu	37	chr20	40730876	40730876	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgattcttatcatggttcCggggcaggagcccaatgctg	7	12	12	10	2	2	0	1	0	1	0	4	2	3	1	2	4	2	3	2	4	2	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:40730876C>A	uc002xkg.2	-	26	3786	c.3602G>T	c.(3601-3603)CGG>CTG	p.R1201L	PTPRT_uc010ggj.2_Missense_Mutation_p.R1220L|PTPRT_uc010ggi.2_Missense_Mutation_p.R404L	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1201	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATCATGGTTCCGGGGCAGGAG	0.557													20	29					2.4624e-09	2.82326e-09	1	0	A	40730876	A	A	40730876	3	1	266	1	0	0	0	0	1	0	0	0	12877	652	23	3	747	3	PTPRT	20	40730876	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	6341406	40730876	22294644	101	48490											
SFRS6	6431	broad.mit.edu	37	chr20	42088474	42088474	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caaatacggaccacctgttcGtacagaatacaggcttattg	13	10	8	10	2	0	1	0	0	0	1	1	2	0	2	2	2	3	3	2	2	6	6			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr20:42088474G>C	uc010zwg.1	+	3	490	c.320G>C	c.(319-321)CGT>CCT	p.R107P	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Missense_Mutation_p.R107P	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	107					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCACCTGTTCGTACAGAATAC	0.393													38	58					0	0	0	0	C	42088474	C	C	42088474	3	2	266	1	0	0	0	0	1	0	0	0	14246	1145	40	3	330	3	SFRS6	20	42088474	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	1357598	42088474	20937046	102	48491											
DGCR14	8220	broad.mit.edu	37	chr22	19130247	19130247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtcctcatacagggtggcGggggctcccgggacatcttg	5	8	17	11	2	2	0	1	0	1	0	4	1	4	1	2	6	1	1	2	6	1	2	rs111488352	byFrequency	TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:19130247G>A	uc002zou.2	-	2	333	c.296C>T	c.(295-297)CCG>CTG	p.P99L	DGCR14_uc002zot.2_Missense_Mutation_p.P20L|DGCR14_uc002zov.2_RNA	NM_022719	NP_073210	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region protein 14	99					nervous system development	catalytic step 2 spliceosome				ovary(1)	1	Colorectal(54;0.0993)					ACAGGGTGGCGGGGGCTCCCG	0.582													5	112					0	0	0	0	A	19130247	A	A	19130247	3	1	266	1	0	0	0	0	1	0	0	0	4482	1116	39	1	1170	1	DGCR14	22	19130247	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08		19130247	32174319	103	48492											
MN1	4330	broad.mit.edu	37	chr22	28193502	28193502	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agcaactcagcccccttcccCcaggatggcgacgtgagcgc	8	5	11	17	3	1	1	1	1	0	0	2	3	2	2	4	2	4	1	4	2	1	1			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:28193502C>G	uc003adj.2	-	1	3985	c.3030G>C	c.(3028-3030)TGG>TGC	p.W1010C		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1010							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						CCCCCTTCCCCCAGGATGGCG	0.692			T	ETV6	AML|meningioma								21	42					0	0	0	0	G	28193502	G	G	28193502	3	3	266	1	0	0	0	0	1	0	0	0	9726	624	22	4	940	4	MN1	22	28193502	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08	9063255	28193502	23111064	104	48493											
OSBP2	23762	broad.mit.edu	37	chr22	31286872	31286872	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctactccaccacagtgcaccGcatcgccaagcccttcaacc	10	6	5	20	2	1	0	1	0	0	0	3	0	2	0	6	0	4	2	6	0	3	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:31286872G>A	uc003aiy.1	+	8	1885	c.1781G>A	c.(1780-1782)CGC>CAC	p.R594H	OSBP2_uc011ala.1_Missense_Mutation_p.R428H|OSBP2_uc010gwc.1_Missense_Mutation_p.R421H|OSBP2_uc011alb.1_Missense_Mutation_p.R545H|OSBP2_uc003aiz.1_Missense_Mutation_p.R593H|OSBP2_uc003aja.1_Missense_Mutation_p.R227H|OSBP2_uc011alc.1_Missense_Mutation_p.R336H|OSBP2_uc003ajb.2_Missense_Mutation_p.R139H|OSBP2_uc011ald.1_Missense_Mutation_p.R138H|OSBP2_uc010gwd.1_Missense_Mutation_p.R139H	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	594					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						ACAGTGCACCGCATCGCCAAG	0.642											OREG0026467	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	36					0	0	0	0	A	31286872	A	A	31286872	3	1	266	1	0	0	0	0	1	0	0	0	11328	1087	38	1	1811	1	OSBP2	22	31286872	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	3093370	31286872	20017694	105	48494											
CSF2RB	1439	broad.mit.edu	37	chr22	37322077	37322077	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctcagtgatgacatgccctgGtcagcctgcccccatccccg	6	8	9	18	1	2	2	2	2	0	0	3	2	3	2	6	1	3	0	6	1	0	0			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:37322077G>A	uc003aqa.3	+	4	466	c.249G>A	c.(247-249)TGG>TGA	p.W83*	CSF2RB_uc003aqc.3_Nonsense_Mutation_p.W83*	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	83	Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	ACATGCCCTGGTCAGCCTGCC	0.547													11	36					0	0	0	0	A	37322077	A	A	37322077	4	1	266	1	0	0	0	0	0	1	0	0	3952	1270	44	4	259	4	CSF2RB	22	37322077	Nonsense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	6035205	37322077	13982489	106	48495											
CYTH4	27128	broad.mit.edu	37	chr22	37695300	37695300	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcaggtcctccaggccttCgtggactgccacgagttcgc	5	9	12	15	3	0	0	0	0	0	0	4	2	2	1	4	3	2	2	4	3	0	2			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:37695300C>T	uc003arf.2	+	6	503	c.387C>T	c.(385-387)TTC>TTT	p.F129F	CYTH4_uc003are.2_Silent_p.F129F|CYTH4_uc011amw.1_Silent_p.F72F|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	129	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TCCAGGCCTTCGTGGACTGCC	0.657													10	22					0	0	0	0	T	37695300	T	T	37695300	2	4	266	1	0	0	0	0	0	0	0	1	4223	883	31	1		1	CYTH4	22	37695300	Silent	SNP	C	TCGA-CV-7434-01A-11D-2129-08	373223	37695300	13609266	107	48496											
PPPDE2	27351	broad.mit.edu	37	chr22	42000099	42000099	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actccagaaagatttcttctGtgacttctgtactccccaca	10	13	5	13	0	3	3	0	1	3	2	5	3	5	3	3	0	1	1	3	0	2	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chr22:42000099G>C	uc003ban.1	-	4	312	c.239C>G	c.(238-240)ACA>AGA	p.T80R	PPPDE2_uc011apb.1_RNA	NM_015704	NP_056519	Q6ICB0	PPDE2_HUMAN	PPPDE peptidase domain containing 2	80	PPPDE peptidase.										0						GATTTCTTCTGTGACTTCTGT	0.527													24	79					0	0	0	0	C	42000099	C	C	42000099	3	2	266	1	0	0	0	0	1	0	0	0	12469	1377	48	4	279	4	PPPDE2	22	42000099	Missense_Mutation	SNP	G	TCGA-CV-7434-01A-11D-2129-08	4304799	42000099	9304467	108	48497											
CNKSR2	22866	broad.mit.edu	37	chrX	21534662	21534662	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggacccgagtggtgttatCttaactttgaaaaagcgacc	12	10	11	8	2	1	1	0	1	1	0	1	5	1	2	2	2	2	1	2	2	4	3			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chrX:21534662C>G	uc004czx.1	+	9	906	c.870C>G	c.(868-870)ATC>ATG	p.I290M	CNKSR2_uc004czw.2_Missense_Mutation_p.I290M|CNKSR2_uc011mjn.1_Intron|CNKSR2_uc011mjo.1_Missense_Mutation_p.I290M	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	290	PDZ.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						GTGGTGTTATCTTAACTTTGA	0.433													29	15					0	0	0	0	G	21534662	G	G	21534662	3	3	266	1	0	0	0	0	1	0	0	0	3622	903	32	2	904	2	CNKSR2	23	21534662	Missense_Mutation	SNP	C	TCGA-CV-7434-01A-11D-2129-08		21534662	133735898	109	48498											
ATRX	546	broad.mit.edu	37	chrX	76776335	76776335	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatcaagctcctggctggcTtgtctacttaatgctaacgc	9	12	8	12	1	2	0	1	0	1	0	3	0	3	0	1	2	4	4	1	2	4	4			TCGA-CV-7434-01A-11D-2129-08	TCGA-CV-7434-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	d64e4e80-e6c6-42c8-8bc6-0fafb6475c51	e03b22c3-93a2-41a7-894f-020298a5f713	g.chrX:76776335T>C	uc004ecp.3	-	34	7363	c.7131A>G	c.(7129-7131)CAA>CAG	p.Q2377Q	ATRX_uc004ecq.3_Silent_p.Q2339Q|ATRX_uc004eco.3_Silent_p.Q2162Q	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2377					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CCTGGCTGGCTTGTCTACTTA	0.378			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						17	10					0	0	0	0	C	76776335	C	C	76776335	2	2	266	1	0	0	0	0	0	0	0	1	1210	1606	56	5		5	ATRX	23	76776335	Silent	SNP	T	TCGA-CV-7434-01A-11D-2129-08	55241673	76776335	78494225	110	48499											
PTCHD2	57540	broad.mit.edu	37	chr1	11596425	11596426	+	Missense_Mutation	DNP	GC	TT	TT																															cgtacgctggaggccgtgcgGcacgtgggcgtggccatcgt																										TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:11596425_11596426GC>TT	uc001ash.3	+	21	3999_4000	c.3861_3862GC>TT	c.(3859-3864)CGGCAC>CGTTAC	p.H1288Y		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1288	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AGGCCGTGCGGCACGTGGGCGT	0.673													25	29					0	0	0	0	TT	11596426	TT	TT	11596425	3	4	267	1	0	0	0	0	1	0	0	0	12795	1190	42	4	3939	4	PTCHD2	1	11596425	Missense_Mutation	DNP	GC	TCGA-CV-7435-01A-11D-2129-08		11596425	237654196	1	48500											
EPHA10	284656	broad.mit.edu	37	chr1	38227471	38227471	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgtccgccgcgatcgtgtcGattttgcggggccggctgcc	2	10	15	14	8	0	0	0	0	0	0	4	2	1	0	4	3	2	1	4	3	0	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:38227471G>A	uc009vvi.2	-	3	542	c.456C>T	c.(454-456)ATC>ATT	p.I152I	EPHA10_uc001cbw.3_Silent_p.I152I	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	152	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CGATCGTGTCGATTTTGCGGG	0.662													13	28					0	0	0	0	A	38227471	A	A	38227471	2	1	267	1	0	0	0	0	0	0	0	1	5190	1048	37	1		1	EPHA10	1	38227471	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08	26631046	38227471	211023150	2	48501											
HOOK1	51361	broad.mit.edu	37	chr1	60314747	60314747	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgtttctgacattaggtTcaagatcttcatgttaaact	10	19	6	6	0	4	2	2	1	2	1	4	2	4	2	0	1	1	3	0	1	4	7			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:60314747T>G	uc009wad.2	+	13	1236	c.1134T>G	c.(1132-1134)GTT>GTG	p.V378V	HOOK1_uc001czo.2_Silent_p.V378V|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Silent_p.V336V	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	378	Potential.|Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					GACATTAGGTTCAAGATCTTC	0.338													20	51					0	0	0	0	G	60314747	G	G	60314747	2	3	267	1	0	0	0	0	0	0	0	1	7321	1770	62	5		5	HOOK1	1	60314747	Silent	SNP	T	TCGA-CV-7435-01A-11D-2129-08	22087276	60314747	188935874	3	48502											
PIGK	10026	broad.mit.edu	37	chr1	77632420	77632420	+	Frame_Shift_Del	DEL	A	-	-																															ttacctgtcatataaattagAatattgcttctgtcatcaga																										TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:77632420delA	uc001dhk.2	-	5	516	c.471delT	c.(469-471)ATTfs	p.I157fs	PIGK_uc010orj.1_Frame_Shift_Del_p.I81fs|PIGK_uc009wbx.2_Frame_Shift_Del_p.I63fs|PIGK_uc001dhl.1_Frame_Shift_Del_p.I157fs	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	157	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						TATAAATTAGAATATTGCTTC	0.333													---	---	---								-	77632420	-	-	77632420	7	5	267	1	0	1	0	1	0	0	0	0	11945	242	9	0	744	0	PIGK	1	77632420	Frame_Shift_Del	DEL	A	TCGA-CV-7435-01A-11D-2129-08	17317673	77632420	171618201	4	48503											
PDE4DIP	9659	broad.mit.edu	37	chr1	144879069	144879069	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgatctcagctcctcagccaGcttctcttctagtccatttt	6	16	5	14	0	4	1	2	1	3	0	8	1	6	1	3	0	3	2	3	0	1	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:144879069G>A	uc001elw.3	-	27	4672	c.4381C>T	c.(4381-4383)CTG>TTG	p.L1461L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L1417L|PDE4DIP_uc001elv.3_Silent_p.L468L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1461					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCTCAGCCAGCTTCTCTTCT	0.517			T	PDGFRB	MPD								15	221					0	0	0	0	A	144879069	A	A	144879069	2	1	267	1	0	0	0	0	0	0	0	1	11697	962	34	4		4	PDE4DIP	1	144879069	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08	67246649	144879069	104371552	5	48504											
NOTCH2NL	388677	broad.mit.edu	37	chr1	145281460	145281460	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccaaccagttctcctgcaaAtgcctcacaggcttcacagg	10	8	8	15	0	3	0	2	0	1	0	4	0	3	0	4	2	3	3	4	2	2	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:145281460A>G	uc001emn.3	+	4	760	c.390A>G	c.(388-390)AAA>AAG	p.K130K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Silent_p.K130K|NOTCH2NL_uc001emo.2_Silent_p.K130K|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	130	EGF-like 4.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						TCTCCTGCAAATGCCTCACAG	0.537													37	404					0	0	0	0	G	145281460	G	G	145281460	2	3	267	1	0	0	0	0	0	0	0	1	10603	98	4	5		5	NOTCH2NL	1	145281460	Silent	SNP	A	TCGA-CV-7435-01A-11D-2129-08	402391	145281460	103969161	6	48505											
CHRNB2	1141	broad.mit.edu	37	chr1	154543837	154543837	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgttcgtggacctacgacCgcacagagatcgacttggtg	8	9	12	12	5	0	1	0	0	0	1	3	5	1	2	3	2	1	2	3	2	1	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:154543837C>T	uc001ffg.2	+	5	802	c.538C>T	c.(538-540)CGC>TGC	p.R180C		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	180	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	GACCTACGACCGCACAGAGAT	0.577													5	48					0	0	0	0	T	154543837	T	T	154543837	3	4	267	1	0	0	0	0	1	0	0	0	3406	652	23	1	556	1	CHRNB2	1	154543837	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	9262377	154543837	94706784	7	48506											
USP21	27005	broad.mit.edu	37	chr1	161132797	161132798	+	Frame_Shift_Ins	INS	-	T	T																															ccgccgggctccaccgatacINSttgccaatggtccagttccc																								rs147410329		TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:161132797_161132798insT	uc010pke.1	+	7	1359_1360	c.982_983insT	c.(982-984)CTTfs	p.L328fs	USP21_uc010pkc.1_Frame_Shift_Ins_p.L328fs|USP21_uc010pkd.1_Frame_Shift_Ins_p.L328fs|USP21_uc010pkf.1_Frame_Shift_Ins_p.L328fs	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	328					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TCCACCGATACTTGCCAATGGT	0.594													---	---	---								T	161132798	T	T	161132797	7	5	267	1	0	1	1	0	0	0	0	0	17121	565	20	0	1000	0	USP21	1	161132797	Frame_Shift_Ins	INS	-	TCGA-CV-7435-01A-11D-2129-08	6588960	161132797	88117824	8	48507											
SLC9A11	284525	broad.mit.edu	37	chr1	173490489	173490489	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttccttgtggcatttcacctCctttacaaatggtatctcca	8	16	5	12	0	2	0	1	0	1	0	5	0	4	0	4	2	1	2	4	2	3	6			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:173490489C>G	uc001giz.2	-	22	3113	c.2690G>C	c.(2689-2691)GGA>GCA	p.G897A	SLC9A11_uc009wwe.2_Missense_Mutation_p.G455A	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	897	cNMP.				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						CATTTCACCTCCTTTACAAAT	0.318													7	51					0	0	0	0	G	173490489	G	G	173490489	3	3	267	1	0	0	0	0	1	0	0	0	14775	855	30	2	712	2	SLC9A11	1	173490489	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	12357692	173490489	75760132	9	48508											
CEP350	9857	broad.mit.edu	37	chr1	179983098	179983098	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgaaaataatataaagaaaCtagcttcatctcttccagat	17	12	4	8	0	2	3	1	1	1	2	4	3	3	3	1	0	2	1	1	0	8	6			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:179983098C>G	uc001gnt.2	+	10	1893	c.1510C>G	c.(1510-1512)CTA>GTA	p.L504V	CEP350_uc009wxl.2_Missense_Mutation_p.L503V|CEP350_uc001gnu.2_Missense_Mutation_p.L338V	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	504						centrosome|nucleus|spindle				ovary(4)	4						TATAAAGAAACTAGCTTCATC	0.368													18	43					0	0	0	0	G	179983098	G	G	179983098	3	3	267	1	0	0	0	0	1	0	0	0	3269	564	20	4	1544	4	CEP350	1	179983098	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	6492609	179983098	69267523	10	48509											
XPR1	9213	broad.mit.edu	37	chr1	180794421	180794421	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggatttatggttttcttcCttatcaaccccaccaaaact	11	15	4	11	0	2	0	1	0	1	0	3	1	3	1	4	2	2	1	4	2	5	6			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:180794421C>T	uc001goi.2	+	9	1267	c.1075C>T	c.(1075-1077)CTT>TTT	p.L359F	XPR1_uc009wxm.2_Missense_Mutation_p.L359F|XPR1_uc009wxn.2_Missense_Mutation_p.L359F	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	359	Helical; (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						GGTTTTCTTCCTTATCAACCC	0.423													40	117					0	0	0	0	T	180794421	T	T	180794421	3	4	267	1	0	0	0	0	1	0	0	0	17519	681	24	4	1109	4	XPR1	1	180794421	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	811323	180794421	68456200	11	48510											
FAM5C	339479	broad.mit.edu	37	chr1	190067993	190067993	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggtcagtttcaaagccaaTatagtgatcggtggactcgg	11	10	12	8	2	2	1	2	1	0	0	4	2	2	2	1	4	1	1	1	4	4	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr1:190067993T>C	uc001gse.1	-	8	1688	c.1456A>G	c.(1456-1458)ATT>GTT	p.I486V	FAM5C_uc010pot.1_Missense_Mutation_p.I384V	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	486						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TCAAAGCCAATATAGTGATCG	0.522													22	158					0	0	0	0	C	190067993	C	C	190067993	3	2	267	1	0	0	0	0	1	0	0	0	5626	1406	49	5	848	5	FAM5C	1	190067993	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08	9273572	190067993	59182628	12	48511											
IAH1	285148	broad.mit.edu	37	chr2	9628388	9628388	+	Frame_Shift_Del	DEL	T	-	-																															ggtctcttctctacctttgcTgcttccttactggcgggatg																										TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr2:9628388delT	uc002qzr.2	+	6	703	c.677delT	c.(676-678)CTGfs	p.L226fs	IAH1_uc002qzs.2_Frame_Shift_Del_p.L113fs|IAH1_uc002qzt.2_Frame_Shift_Del_p.L113fs|IAH1_uc010yiz.1_RNA	NM_001039613	NP_001034702	Q2TAA2	IAH1_HUMAN	isoamyl acetate-hydrolyzing esterase 1 homolog	226					lipid catabolic process		hydrolase activity, acting on ester bonds				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTACCTTTGCTGCTTCCTTAC	0.433													---	---	---								-	9628388	-	-	9628388	7	5	267	1	0	1	0	1	0	0	0	0	7510	1580	55	0	699	0	IAH1	2	9628388	Frame_Shift_Del	DEL	T	TCGA-CV-7435-01A-11D-2129-08		9628388	233570985	13	48512											
CD207	50489	broad.mit.edu	37	chr2	71060135	71060136	+	Frame_Shift_Ins	INS	-	C	C																															agagaaaagtaatagaagttINSccccttgaagtacttccagc																										TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr2:71060135_71060136insC	uc002shg.2	-	4	659_660	c.612_613insG	c.(610-615)GGGAACfs	p.G204fs		NM_015717	NP_056532	Q9UJ71	CLC4K_HUMAN	CD207 antigen, langerin	204_205	C-type lectin.|Extracellular (Potential).				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			ovary(1)|lung(1)	2						TAATAGAAGTTCCCCTTGAAGT	0.446													---	---	---								C	71060136	C	C	71060135	7	5	267	1	0	1	1	0	0	0	0	0	2998	1783	62	0	385	0	CD207	2	71060135	Frame_Shift_Ins	INS	-	TCGA-CV-7435-01A-11D-2129-08	61431747	71060135	172139238	14	48513											
PLCL1	5334	broad.mit.edu	37	chr2	199011631	199011631	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgctgaggccaagagcaagcGcagcctggaagccatagagg	12	4	15	10	1	0	3	0	1	0	2	0	4	0	4	3	3	5	3	3	3	4	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr2:199011631G>A	uc010fsp.2	+	6	3524	c.3233G>A	c.(3232-3234)CGC>CAC	p.R1078H	PLCL1_uc002uuv.3_Missense_Mutation_p.R999H	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	1078					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AAGAGCAAGCGCAGCCTGGAA	0.512													12	31					0	0	0	0	A	199011631	A	A	199011631	3	1	267	1	0	0	0	0	1	0	0	0	12094	1087	38	1	3255	1	PLCL1	2	199011631	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	127951496	199011631	44187742	15	48514											
FZD7	8324	broad.mit.edu	37	chr2	202899737	202899737	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatcccgccgtgtcgttctCtgtgcgagcgcgcccgccag	3	8	12	18	7	1	0	0	0	1	0	4	1	2	0	5	0	2	1	5	0	0	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr2:202899737C>T	uc002uyw.1	+	1	428	c.367C>T	c.(367-369)CTG>TTG	p.L123L		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	123	FZ.|Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						GTGTCGTTCTCTGTGCGAGCG	0.642											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	65					0	0	0	0	T	202899737	T	T	202899737	2	4	267	1	0	0	0	0	0	0	0	1	6169	912	32	2		2	FZD7	2	202899737	Silent	SNP	C	TCGA-CV-7435-01A-11D-2129-08	3888106	202899737	40299636	16	48515											
C2orf57	165100	broad.mit.edu	37	chr2	232458286	232458286	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccccacaccctgaagctgaAgctttaccatctgatgagtc	10	9	8	14	0	1	4	0	4	1	0	2	4	1	4	4	0	3	2	4	0	3	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr2:232458286A>C	uc002vrz.2	+	1	675	c.624A>C	c.(622-624)GAA>GAC	p.E208D		NM_152614	NP_689827	Q53QW1	CB057_HUMAN	hypothetical protein LOC165100	208										ovary(1)	1		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		CTGAAGCTGAAGCTTTACCAT	0.582													10	117					0	0	0	0	C	232458286	C	C	232458286	3	2	267	1	0	0	0	0	1	0	0	0	2188	69	3	5	626	5	C2orf57	2	232458286	Missense_Mutation	SNP	A	TCGA-CV-7435-01A-11D-2129-08	29558549	232458286	10741087	17	48516											
FBLN2	2199	broad.mit.edu	37	chr3	13611903	13611903	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctggcttgctctgggcctGgccctggccctgggccccag	1	8	15	17	0	1	0	0	0	1	0	1	0	1	0	6	5	1	2	6	5	0	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	f2192c96-2c1b-435a-ba30-a29247b9f1b7	g.chr3:13611903G>T	uc011avb.1	+	2	173	c.48G>T	c.(46-48)CTG>CTT	p.L16L	FBLN2_uc011auz.1_Silent_p.L42L|FBLN2_uc011ava.1_Silent_p.L16L|FBLN2_uc011avc.1_Silent_p.L16L	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	16						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CTCTGGGCCTGGCCCTGGCCC	0.706													3	3					1.024e-07	1.1433e-07	1	0	T	13611903	T	T	13611903	2	4	267	1	0	0	0	0	0	0	0	1	5731	1335	47	4		4	FBLN2	3	13611903	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08		13611903	184410527	18	48517											
C3orf39	84892	broad.mit.edu	37	chr3	43122688	43122688	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagagccacttgaagcggCagatgcggtctgtgtgcgtg	8	8	16	9	3	1	3	0	1	1	2	1	3	1	3	1	2	5	2	1	2	1	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr3:43122688C>G	uc003cmq.1	-	2	377	c.236G>C	c.(235-237)TGC>TCC	p.C79S	C3orf39_uc003cmr.1_Missense_Mutation_p.C79S	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	79						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)		CTTGAAGCGGCAGATGCGGTC	0.617													13	32					0	0	0	0	G	43122688	G	G	43122688	3	3	267	1	0	0	0	0	1	0	0	0	2239	710	25	4	1510	4	C3orf39	3	43122688	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	29510785	43122688	154899742	19	48518											
ARL13B	200894	broad.mit.edu	37	chr3	93769695	93769695	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaacccctaaagtcactaGacttccaaaacttgagcctc	13	8	7	13	0	1	2	1	1	0	1	3	3	2	3	4	1	3	0	4	1	6	4			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr3:93769695G>A	uc003drc.2	+	9	1455	c.1169G>A	c.(1168-1170)AGA>AAA	p.R390K	ARL13B_uc010hop.2_Missense_Mutation_p.R241K|ARL13B_uc003drd.2_Missense_Mutation_p.R283K|ARL13B_uc003dre.2_Missense_Mutation_p.R375K|ARL13B_uc003drf.2_Missense_Mutation_p.R390K|ARL13B_uc003drg.2_Missense_Mutation_p.R287K	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	390	Pro-rich.						GTP binding				0						AAAGTCACTAGACTTCCAAAA	0.368													13	43					0	0	0	0	A	93769695	A	A	93769695	3	1	267	1	0	0	0	0	1	0	0	0	929	942	33	2	1203	2	ARL13B	3	93769695	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	50647007	93769695	104252735	20	48519											
UROC1	131669	broad.mit.edu	37	chr3	126224562	126224562	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acctctgctatcacaccgatGcaccccacgatgactgcggc	9	7	8	17	3	2	1	1	1	1	0	2	3	2	1	4	1	3	2	4	1	1	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr3:126224562G>A	uc003eiz.1	-	8	827	c.795C>T	c.(793-795)TGC>TGT	p.C265C	UROC1_uc010hsi.1_Silent_p.C265C	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	265					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		TCACACCGATGCACCCCACGA	0.413													15	37					0	0	0	0	A	126224562	A	A	126224562	2	1	267	1	0	0	0	0	0	0	0	1	17096	1311	46	4		4	UROC1	3	126224562	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08	32454867	126224562	71797868	21	48520											
PLSCR1	5359	broad.mit.edu	37	chr3	146246480	146246494	+	In_Frame_Del	DEL	ACTGGCTGATTATAT	-	-																															atggtacccctgcagctccaActggctgattatatactggc																								rs147509085	byFrequency	TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr3:146246480_146246494delACTGGCTGATTATAT	uc003evx.3	-	4	607_621	c.219_233delATATAATCAGCCAGT	c.(217-234)GTATATAATCAGCCAGTT>GTT	p.73_78VYNQPV>V	PLSCR1_uc003evy.3_In_Frame_Del_p.66_71VYNQPV>V|PLSCR1_uc011bnn.1_Intron|PLSCR1_uc003evz.3_Intron|PLSCR1_uc003ewa.2_In_Frame_Del_p.73_78VYNQPV>V	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	73_78	Cytoplasmic.				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						TGCAGCTCCAACTGGCTGATTATATACTGGCTGAT	0.521													---	---	---								-	146246494	-	-	146246480	7	5	267	1	0	1	0	1	0	0	0	0	12164	43	2	0	747	0	PLSCR1	3	146246480	In_Frame_Del	DEL	ACTGGCTGATTATAT	TCGA-CV-7435-01A-11D-2129-08	20021918	146246480	51775950	22	48521											
MED12L	116931	broad.mit.edu	37	chr3	150908705	150908705	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactattcaaaggaccatgAtgtgaaaatggaggtatggc	15	9	11	6	0	1	2	1	2	0	0	1	4	1	4	1	4	0	1	1	4	5	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr3:150908705A>T	uc003eyp.2	+	13	1993	c.1955A>T	c.(1954-1956)GAT>GTT	p.D652V	MED12L_uc011bnz.1_Missense_Mutation_p.D512V|MED12L_uc003eyn.2_Missense_Mutation_p.D652V|MED12L_uc003eyo.2_Missense_Mutation_p.D652V	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	652					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGGACCATGATGTGAAAATG	0.483													11	35					0	0	0	0	T	150908705	T	T	150908705	3	4	267	1	0	0	0	0	1	0	0	0	9482	333	12	5	2005	5	MED12L	3	150908705	Missense_Mutation	SNP	A	TCGA-CV-7435-01A-11D-2129-08	4662225	150908705	47113725	23	48522											
PLD1	5337	broad.mit.edu	37	chr3	171394576	171394576	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcccgtggactgcagaggCaatgtcatgccagggcatcc	8	8	12	13	1	1	1	1	0	0	1	3	2	3	2	3	3	2	3	3	3	1	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr3:171394576C>T	uc003fhs.2	-	18	2160	c.2044G>A	c.(2044-2046)GCC>ACC	p.A682T	PLD1_uc003fht.2_Missense_Mutation_p.A644T|PLD1_uc003fhu.3_5'Flank|PLD1_uc003fhv.1_Missense_Mutation_p.A7T	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	682	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ACTGCAGAGGCAATGTCATGC	0.527													13	78					0	0	0	0	T	171394576	T	T	171394576	3	4	267	1	0	0	0	0	1	0	0	0	12100	710	25	4	1220	4	PLD1	3	171394576	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	20485871	171394576	26627854	24	48523											
LRRC15	131578	broad.mit.edu	37	chr3	194081302	194081302	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtattccaggtggttgccGtgcaactgcagctccttgag	7	12	12	10	1	0	1	0	1	0	0	2	1	2	1	3	2	5	5	3	2	2	4	rs143343570	byFrequency	TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr3:194081302G>A	uc003ftu.2	-	2	557	c.471C>T	c.(469-471)CAC>CAT	p.H157H	LRRC15_uc003ftt.2_Silent_p.H163H	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	157	Extracellular (Potential).|LRR 5.					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		GGTGGTTGCCGTGCAACTGCA	0.572													31	251					0	0	0	0	A	194081302	A	A	194081302	2	1	267	1	0	0	0	0	0	0	0	1	9020	1136	40	1		1	LRRC15	3	194081302	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08	22686726	194081302	3941128	25	48524											
MAP9	79884	broad.mit.edu	37	chr4	156274418	156274418	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctttttggcagctattttCtttgcttccttttctttcat	3	24	4	10	0	4	0	1	0	3	0	5	0	5	0	1	1	2	3	1	1	1	10			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr4:156274418C>A	uc003ios.2	-	11	1719	c.1455G>T	c.(1453-1455)AAG>AAT	p.K485N	MAP9_uc011cin.1_Missense_Mutation_p.K460N|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.K484N	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	485	Potential.				cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CAGCTATTTTCTTTGCTTCCT	0.353													10	53					1.76689e-08	1.98565e-08	1	0	A	156274418	A	A	156274418	3	1	267	1	0	0	0	0	1	0	0	0	9323	912	32	2	504	2	MAP9	4	156274418	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08		156274418	34879858	26	48525											
FAT1	2195	broad.mit.edu	37	chr4	187629852	187629853	+	Frame_Shift_Ins	INS	-	T	T																															gttgggaggagcaaattcacINSttatttctgctctgtaaaca																										TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr4:187629852_187629853insT	uc003izf.2	-	2	1317_1318	c.1129_1130insA	c.(1129-1131)AGTfs	p.S377fs	FAT1_uc010iso.1_Frame_Shift_Ins_p.S377fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	377	Extracellular (Potential).|Cadherin 3.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AGCAAATTCACTTATTTCTGCT	0.431										HNSCC(5;0.00058)			---	---	---								T	187629853	T	T	187629852	7	5	267	1	0	1	1	0	0	0	0	0	5721	565	20	0	12740	0	FAT1	4	187629852	Frame_Shift_Ins	INS	-	TCGA-CV-7435-01A-11D-2129-08	31355434	187629852	3524424	27	48526											
HEATR7B2	133558	broad.mit.edu	37	chr5	41065470	41065470	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcagccagggcaagcacaacGaattcatctggtagctctaa	13	8	9	11	1	4	0	2	0	2	0	4	1	4	0	1	2	4	4	1	2	5	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr5:41065470G>A	uc003jmj.3	-	4	814	c.324C>T	c.(322-324)TTC>TTT	p.F108F		NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	108							binding			ovary(6)|central_nervous_system(2)	8						CAAGCACAACGAATTCATCTG	0.418													12	18					0	0	0	0	A	41065470	A	A	41065470	2	1	267	1	0	0	0	0	0	0	0	1	7074	1049	37	1		1	HEATR7B2	5	41065470	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08		41065470	139849790	28	48527											
APC	324	broad.mit.edu	37	chr5	112173816	112173816	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatcaagaggaagcttagAtagttctcgttctgaaaaag	14	12	9	6	1	4	3	2	1	2	2	5	4	4	4	0	1	1	3	0	1	6	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr5:112173816A>T	uc010jby.2	+	16	2905	c.2525A>T	c.(2524-2526)GAT>GTT	p.D842V	APC_uc011cvt.1_Missense_Mutation_p.D824V|APC_uc003kpz.3_Missense_Mutation_p.D842V|APC_uc003kpy.3_Missense_Mutation_p.D842V|APC_uc010jbz.2_Missense_Mutation_p.D559V|APC_uc010jca.2_Missense_Mutation_p.D142V	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	842	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GGAAGCTTAGATAGTTCTCGT	0.403		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			17	43					0	0	0	0	T	112173816	T	T	112173816	3	4	267	1	0	0	0	0	1	0	0	0	763	333	12	5	2583	5	APC	5	112173816	Missense_Mutation	SNP	A	TCGA-CV-7435-01A-11D-2129-08	71108346	112173816	68741444	29	48528											
RAD50	10111	broad.mit.edu	37	chr5	131911505	131911505	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtgagagcccagattcgtCtgcaatttcgtgatgtcaat	10	13	10	8	2	2	3	1	2	1	2	4	4	2	3	1	0	2	1	1	0	2	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr5:131911505C>T	uc003kxi.2	+	3	637	c.250C>T	c.(250-252)CTG>TTG	p.L84L	RAD50_uc003kxg.1_5'UTR|RAD50_uc003kxh.2_5'UTR	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	84					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCAGATTCGTCTGCAATTTCG	0.378								Homologous_recombination					12	46					0	0	0	0	T	131911505	T	T	131911505	2	4	267	1	0	0	0	0	0	0	0	1	13049	912	32	2		2	RAD50	5	131911505	Silent	SNP	C	TCGA-CV-7435-01A-11D-2129-08	19737689	131911505	49003755	30	48529											
PPP2R2B	5521	broad.mit.edu	37	chr5	146077680	146077680	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgctgtaaacattgtattCacccctacgatgaacctgat	11	13	7	10	1	1	2	1	2	0	0	1	3	1	2	3	0	4	3	3	0	5	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr5:146077680C>T	uc003loe.2	-	3	721	c.196G>A	c.(196-198)GAA>AAA	p.E66K	PPP2R2B_uc010jgm.2_Missense_Mutation_p.E55K|PPP2R2B_uc003log.3_Missense_Mutation_p.E66K|PPP2R2B_uc003lof.3_Missense_Mutation_p.E66K|PPP2R2B_uc003loi.3_Missense_Mutation_p.E69K|PPP2R2B_uc003loh.3_Missense_Mutation_p.E66K|PPP2R2B_uc003loj.3_Missense_Mutation_p.E46K|PPP2R2B_uc003lok.3_Missense_Mutation_p.E55K|PPP2R2B_uc011dbu.1_Missense_Mutation_p.E72K|PPP2R2B_uc011dbv.1_Missense_Mutation_p.E124K	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	66					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACATTGTATTCACCCCTACGA	0.373													33	52					0	0	0	0	T	146077680	T	T	146077680	3	4	267	1	0	0	0	0	1	0	0	0	12445	835	29	2	1163	2	PPP2R2B	5	146077680	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	14166175	146077680	34837580	31	48530											
WWC1	23286	broad.mit.edu	37	chr5	167812359	167812359	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagcgcctggagcttgcaCagcaggagtaccagcaactg	11	5	13	12	1	0	0	0	0	0	0	0	2	0	2	2	2	8	6	2	2	2	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr5:167812359C>T	uc003lzu.2	+	3	466	c.373C>T	c.(373-375)CAG>TAG	p.Q125*	WWC1_uc003lzv.2_Nonsense_Mutation_p.Q125*|WWC1_uc011den.1_Nonsense_Mutation_p.Q125*	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	125	Potential.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GGAGCTTGCACAGCAGGAGTA	0.587													16	31					0	0	0	0	T	167812359	T	T	167812359	4	4	267	1	0	0	0	0	0	1	0	0	17479	479	17	4	383	4	WWC1	5	167812359	Nonsense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	21734679	167812359	13102901	32	48531											
HIST1H4E	8367	broad.mit.edu	37	chr6	26205057	26205057	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcgcggggttctgaaggtgtTtctggaaaacgtgattcgtg	7	13	15	6	4	2	2	0	2	2	0	4	3	2	3	0	4	1	2	0	4	3	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr6:26205057T>G	uc003ngy.2	+	1	185	c.185T>G	c.(184-186)TTT>TGT	p.F62C		NM_003545	NP_003536	P62805	H4_HUMAN	histone cluster 1, H4e	62					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				CTGAAGGTGTTTCTGGAAAAC	0.567													13	88					0	0	0	0	G	26205057	G	G	26205057	3	3	267	1	0	0	0	0	1	0	0	0	7208	1841	64	5	187	5	HIST1H4E	6	26205057	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08		26205057	144910010	33	48532											
C6orf27	80737	broad.mit.edu	37	chr6	31743155	31743155	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccttggccagaggaggtgagGgtgtggctgctgctcgccca	5	8	17	11	1	0	2	0	1	0	1	1	3	0	3	3	5	2	3	3	5	0	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr6:31743155G>T	uc011dog.1	-	4	803	c.565C>A	c.(565-567)CCT>ACT	p.P189T	C6orf27_uc003nxd.2_5'UTR|C6orf27_uc011doh.1_RNA	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	189						extracellular region				ovary(3)	3						AGGAGGTGAGGGTGTGGCTGC	0.612													18	31					5.35267e-07	5.90294e-07	1	0	T	31743155	T	T	31743155	3	4	267	1	0	0	0	0	1	0	0	0	2372	1232	43	4	2165	4	C6orf27	6	31743155	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	5538098	31743155	139371912	34	48533											
FAM83B	222584	broad.mit.edu	37	chr6	54804590	54804590	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcctttgatgaagaatttaGaactctctatgccagatcct	11	14	7	9	0	1	5	0	2	1	3	4	5	3	5	3	0	2	0	3	0	5	4			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr6:54804590G>A	uc003pck.2	+	5	937	c.821G>A	c.(820-822)AGA>AAA	p.R274K		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	274										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					GAAGAATTTAGAACTCTCTAT	0.423													11	60					0	0	0	0	A	54804590	A	A	54804590	3	1	267	1	0	0	0	0	1	0	0	0	5666	942	33	2	835	2	FAM83B	6	54804590	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	23061435	54804590	116310477	35	48534											
MDN1	23195	broad.mit.edu	37	chr6	90497660	90497660	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctctccattctccaagagaGggatcagcacagaaacctaa	14	7	8	12	0	3	2	1	0	2	2	5	4	3	3	3	1	2	2	3	1	3	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr6:90497660G>A	uc003pnn.1	-	8	1363	c.1247C>T	c.(1246-1248)CCT>CTT	p.P416L	MDN1_uc003pno.1_5'Flank|MDN1_uc003pnp.1_Missense_Mutation_p.P416L	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	416					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CTCCAAGAGAGGGATCAGCAC	0.408													25	36					0	0	0	0	A	90497660	A	A	90497660	3	1	267	1	0	0	0	0	1	0	0	0	9468	1000	35	4	15923	4	MDN1	6	90497660	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	35693070	90497660	80617407	36	48535											
GTF3C6	112495	broad.mit.edu	37	chr6	111288940	111288941	+	Frame_Shift_Ins	INS	-	T	T																															ttctggtcctcttattgataINStaccttctgagacagaaggt																								rs41289884	byFrequency	TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr6:111288940_111288941insT	uc003pum.2	+	6	799_800	c.589_590insT	c.(589-591)ATAfs	p.I197fs		NM_138408	NP_612417	Q969F1	TF3C6_HUMAN	general transcription factor IIIC, polypeptide	197						transcription factor TFIIIC complex	DNA binding|protein binding				0		all_cancers(87;0.00328)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|Colorectal(196;0.0466)|all_epithelial(87;0.0575)		OV - Ovarian serous cystadenocarcinoma(136;0.105)|all cancers(137;0.179)|Epithelial(106;0.186)		TCTTATTGATATACCTTCTGAG	0.371													---	---	---								T	111288941	T	T	111288940	7	5	267	1	0	1	1	0	0	0	0	0	6916	449	16	0	611	0	GTF3C6	6	111288940	Frame_Shift_Ins	INS	-	TCGA-CV-7435-01A-11D-2129-08	20791280	111288940	59826127	37	48536											
MIOS	54468	broad.mit.edu	37	chr7	7636027	7636027	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacaagttgtcctggctgtcGaaaaccacttcctcgatgtg	9	11	9	12	2	0	0	0	0	0	0	4	2	2	0	3	1	1	2	3	1	3	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr7:7636027G>A	uc003srf.2	+	11	2644	c.2336G>A	c.(2335-2337)CGA>CAA	p.R779Q	MIOS_uc003srg.2_Missense_Mutation_p.R314Q|MIOS_uc010ktq.2_Missense_Mutation_p.R174Q	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	779											0						CCTGGCTGTCGAAAACCACTT	0.428													11	154					0	0	0	0	A	7636027	A	A	7636027	3	1	267	1	0	0	0	0	1	0	0	0	9642	1058	37	1	2366	1	MIOS	7	7636027	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08		7636027	151502636	38	48537											
SEMA3C	10512	broad.mit.edu	37	chr7	80435066	80435066	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatatacattccagagaaaaGctcctcatctatgaaaaaga	18	10	5	8	0	2	3	1	1	1	2	4	4	4	3	2	0	2	1	2	0	8	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr7:80435066G>A	uc003uhj.2	-	7	1109	c.547C>T	c.(547-549)CTT>TTT	p.L183F	SEMA3C_uc011kgw.1_Missense_Mutation_p.L201F|SEMA3C_uc011kgx.1_Missense_Mutation_p.L35F	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	183	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						CCAGAGAAAAGCTCCTCATCT	0.323													17	34					0	0	0	0	A	80435066	A	A	80435066	3	1	267	1	0	0	0	0	1	0	0	0	14091	971	34	4	1756	4	SEMA3C	7	80435066	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	72799039	80435066	78703597	39	48538											
PCLO	27445	broad.mit.edu	37	chr7	82387992	82387992	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaggcttcaccaatcaaggTctttttcataaacttccctc	11	13	4	13	0	4	0	3	0	1	0	6	0	5	0	2	2	1	1	2	2	4	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr7:82387992T>G	uc003uhx.2	-	25	15617	c.15328A>C	c.(15328-15330)ACC>CCC	p.T5110P		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	5033	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CCAATCAAGGTCTTTTTCATA	0.333													32	107					0	0	0	0	G	82387992	G	G	82387992	3	3	267	1	0	0	0	0	1	0	0	0	11637	1667	58	5	104	5	PCLO	7	82387992	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08	1952926	82387992	76750671	40	48539											
PODXL	5420	broad.mit.edu	37	chr7	131194197	131194197	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagttgatgctgctgtggggCtggagctcatggtctctggc	4	13	16	8	0	2	1	1	1	1	0	3	2	2	2	0	5	3	5	0	5	1	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr7:131194197C>T	uc003vqw.3	-	4	1208	c.950G>A	c.(949-951)AGC>AAC	p.S317N	PODXL_uc003vqx.3_Missense_Mutation_p.S285N	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	podocalyxin-like isoform 1 precursor	317	Thr-rich.|Extracellular (Potential).				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)					TGCTGTGGGGCTGGAGCTCAT	0.602													45	85					0	0	0	0	T	131194197	T	T	131194197	3	4	267	1	0	0	0	0	1	0	0	0	12235	797	28	4	750	4	PODXL	7	131194197	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	48806205	131194197	27944466	41	48540											
LONRF1	91694	broad.mit.edu	37	chr8	12586780	12586780	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttggctcaaatacatggaGagggcaaggcacagtggggt	11	8	15	7	0	2	1	1	0	1	1	2	2	2	1	0	6	1	3	0	6	3	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr8:12586780G>C	uc003wwd.1	-	9	1813	c.1750C>G	c.(1750-1752)CTC>GTC	p.L584V	LONRF1_uc011kxv.1_Missense_Mutation_p.L173V|LONRF1_uc010lsp.1_Missense_Mutation_p.L184V	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	584	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		AATACATGGAGAGGGCAAGGC	0.388													19	59					0	0	0	0	C	12586780	C	C	12586780	3	2	267	1	0	0	0	0	1	0	0	0	8944	942	33	2	587	2	LONRF1	8	12586780	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08		12586780	133777242	42	48541											
PURG	29942	broad.mit.edu	37	chr8	30890027	30890027	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgccggcctctccctatcCagacttcggctatctttagg	5	12	8	16	2	2	1	0	0	2	1	5	1	3	1	5	3	1	1	5	3	3	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr8:30890027C>T	uc003xin.2	-	1	291	c.272G>A	c.(271-273)TGG>TAG	p.W91*	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Nonsense_Mutation_p.W91*	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	91	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		TCTCCCTATCCAGACTTCGGC	0.547													21	36					0	0	0	0	T	30890027	T	T	30890027	4	4	267	1	0	0	0	0	0	1	0	0	12894	595	21	4	884	4	PURG	8	30890027	Nonsense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	18303247	30890027	115473995	43	48542											
TM7SF4	81501	broad.mit.edu	37	chr8	105367322	105367322	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccccagcgtggagaggaagcGcatccaatatctgcatgcaa	12	6	11	12	2	1	1	0	0	1	1	2	3	2	2	3	2	4	3	3	2	4	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr8:105367322G>A	uc003ylx.1	+	3	1296	c.1247G>A	c.(1246-1248)CGC>CAC	p.R416H		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	416	Cytoplasmic.				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GAGAGGAAGCGCATCCAATAT	0.443													5	83					0	0	0	0	A	105367322	A	A	105367322	3	1	267	1	0	0	0	0	1	0	0	0	16042	1087	38	1	1253	1	TM7SF4	8	105367322	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	74477295	105367322	40996700	44	48543											
EIF3H	8667	broad.mit.edu	37	chr8	117671059	117671059	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctcctactaaccataaatGagaacgacagattcttcaat	16	10	4	11	1	2	2	1	1	1	2	3	4	3	2	3	0	3	0	3	0	6	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr8:117671059G>A	uc003yoa.2	-	3	476	c.450C>T	c.(448-450)CTC>CTT	p.L150L	EIF3H_uc003yob.2_Silent_p.L164L|EIF3H_uc011lhz.1_Silent_p.L150L	NM_003756	NP_003747	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3,	150					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					AACCATAAATGAGAACGACAG	0.413													24	107					0	0	0	0	A	117671059	A	A	117671059	2	1	267	1	0	0	0	0	0	0	0	1	5042	1277	45	2		2	EIF3H	8	117671059	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08	12303737	117671059	28692963	45	48544											
PIP5K1B	8395	broad.mit.edu	37	chr9	71503904	71503904	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttacccttttagtattccaTctgcagtgaacctctaatag	10	16	5	10	0	2	1	0	1	2	0	3	1	3	1	3	0	3	2	3	0	6	8			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr9:71503904T>A	uc004agu.2	+	7	631	c.326T>A	c.(325-327)ATC>AAC	p.I109N	PIP5K1B_uc011lrq.1_Missense_Mutation_p.I109N|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	109	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		TAGTATTCCATCTGCAGTGAA	0.383													41	68					0	0	0	0	A	71503904	A	A	71503904	3	1	267	1	0	0	0	0	1	0	0	0	11995	1435	50	5	340	5	PIP5K1B	9	71503904	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08		71503904	69709527	46	48545											
AGTPBP1	23287	broad.mit.edu	37	chr9	88293287	88293287	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaagaatgcttaagatattAagtgtagtttgaagatcttt	15	15	8	3	0	1	4	0	1	1	3	1	4	1	4	0	0	1	3	0	0	7	6			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr9:88293287A>T	uc011ltd.1	-	4	285	c.252T>A	c.(250-252)CTT>CTA	p.L84L	AGTPBP1_uc011ltc.1_Silent_p.L26L|AGTPBP1_uc010mqc.2_Silent_p.L84L|AGTPBP1_uc011lte.1_Silent_p.L136L	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	84					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						TTAAGATATTAAGTGTAGTTT	0.308													4	15					0	0	0	0	T	88293287	T	T	88293287	2	4	267	1	0	0	0	0	0	0	0	1	400	349	13	5		5	AGTPBP1	9	88293287	Silent	SNP	A	TCGA-CV-7435-01A-11D-2129-08	16789383	88293287	52920144	47	48546											
C9orf156	51531	broad.mit.edu	37	chr9	100672670	100672670	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggtttcctcttagtgctaTggtggggttgtggctcatca	5	16	13	7	0	3	0	2	0	1	0	4	0	4	0	1	5	1	4	1	5	3	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr9:100672670T>C	uc004axv.1	-	4	715	c.638A>G	c.(637-639)CAT>CGT	p.H213R	C9orf156_uc004axw.1_Missense_Mutation_p.H110R|C9orf156_uc004axx.1_Missense_Mutation_p.H67R|C9orf156_uc010msq.1_Missense_Mutation_p.H110R	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	213					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				CTTAGTGCTATGGTGGGGTTG	0.473													17	42					0	0	0	0	C	100672670	C	C	100672670	3	2	267	1	0	0	0	0	1	0	0	0	2477	1464	51	5	695	5	C9orf156	9	100672670	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08	12379383	100672670	40540761	48	48547											
ODF2	4957	broad.mit.edu	37	chr9	131221864	131221864	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtttccatcgtgtgggaaGaacggagtaacgagtctcac	11	9	13	8	3	1	1	1	0	1	1	4	4	2	3	1	3	2	2	1	3	3	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr9:131221864G>A	uc011mbd.1	+	3	362	c.51G>A	c.(49-51)AAG>AAA	p.K17K	ODF2_uc011maz.1_Silent_p.K17K|ODF2_uc011mba.1_5'UTR|ODF2_uc010myb.2_5'UTR|ODF2_uc011mbb.1_5'UTR|ODF2_uc011mbc.1_5'UTR|ODF2_uc004bva.2_5'UTR|ODF2_uc004bvb.2_5'UTR|ODF2_uc011mbe.1_5'UTR|ODF2_uc004bvc.2_5'UTR|ODF2_uc010myc.2_Silent_p.K17K|ODF2_uc011mbf.1_Silent_p.K17K|ODF2_uc004bvd.3_Silent_p.K17K|ODF2_uc004bve.2_Silent_p.K17K	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	17					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						CGTGTGGGAAGAACGGAGTAA	0.483													9	13					0	0	0	0	A	131221864	A	A	131221864	2	1	267	1	0	0	0	0	0	0	0	1	10881	933	33	2		2	ODF2	9	131221864	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08	30549194	131221864	9991567	49	48548											
CDNF	441549	broad.mit.edu	37	chr10	14870200	14870200	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgatcaattctttctctaTagtgtccagcgaaaagttaa	13	14	6	8	1	3	1	1	1	2	0	5	2	4	1	1	0	1	1	1	0	6	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr10:14870200T>C	uc001inb.1	-	2	225	c.187A>G	c.(187-189)ATA>GTA	p.I63V	CDNF_uc010qbv.1_Missense_Mutation_p.I63V|CDNF_uc001inc.1_5'UTR	NM_001029954	NP_001025125	Q49AH0	CDNF_HUMAN	arginine-rich, mutated in early stage	63						extracellular region	growth factor activity				0						TCTTTCTCTATAGTGTCCAGC	0.368													29	105					0	0	0	0	C	14870200	C	C	14870200	3	2	267	1	0	0	0	0	1	0	0	0	3183	1406	49	5	388	5	CDNF	10	14870200	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08		14870200	120664547	50	48549											
PCDH15	65217	broad.mit.edu	37	chr10	55955480	55955480	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagagctactattcttaaaGgtgaagtcaaattgagactg	14	11	9	7	0	2	3	1	2	1	2	2	4	2	3	1	1	2	1	1	1	6	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr10:55955480G>T	uc001jju.1	-	11	1663	c.1268C>A	c.(1267-1269)CCT>CAT	p.P423H	PCDH15_uc010qhq.1_Missense_Mutation_p.P428H|PCDH15_uc010qhr.1_Missense_Mutation_p.P423H|PCDH15_uc010qhs.1_Missense_Mutation_p.P428H|PCDH15_uc010qht.1_Missense_Mutation_p.P423H|PCDH15_uc010qhu.1_Missense_Mutation_p.P423H|PCDH15_uc001jjv.1_Missense_Mutation_p.P401H|PCDH15_uc010qhv.1_Missense_Mutation_p.P423H|PCDH15_uc010qhw.1_Missense_Mutation_p.P386H|PCDH15_uc010qhx.1_Missense_Mutation_p.P423H|PCDH15_uc010qhy.1_Missense_Mutation_p.P428H|PCDH15_uc010qhz.1_Missense_Mutation_p.P423H|PCDH15_uc010qia.1_Missense_Mutation_p.P401H|PCDH15_uc010qib.1_Missense_Mutation_p.P401H|PCDH15_uc001jjw.2_Missense_Mutation_p.P423H	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	423	Cadherin 4.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TATTCTTAAAGGTGAAGTCAA	0.368										HNSCC(58;0.16)			10	108					4.68919e-08	5.22004e-08	1	0	T	55955480	T	T	55955480	3	4	267	1	0	0	0	0	1	0	0	0	11565	1000	35	4	6335	4	PCDH15	10	55955480	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	41085280	55955480	79579267	51	48550											
ZNF365	22891	broad.mit.edu	37	chr10	64148197	64148197	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctggaagcggcagctgaGaaggaggttcaagggaaagc	12	6	16	7	1	1	1	1	1	0	1	2	5	2	4	1	5	3	3	1	5	4	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr10:64148197G>A	uc001jmc.2	+	3	1101	c.786G>A	c.(784-786)GAG>GAA	p.E262E	ZNF365_uc001jly.3_Silent_p.E277E|ZNF365_uc001jmb.3_Silent_p.E262E|ZNF365_uc001jlz.3_Silent_p.E262E|ZNF365_uc001jma.3_RNA	NM_199451	NP_955523	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform C	Error:Variant_position_missing_in_Q70YC4_after_alignment										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					CGGCAGCTGAGAAGGAGGTTC	0.458													7	57					0	0	0	0	A	64148197	A	A	64148197	2	1	267	1	0	0	0	0	0	0	0	1	17936	933	33	2		2	ZNF365	10	64148197	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08	8192717	64148197	71386550	52	48551											
TET1	80312	broad.mit.edu	37	chr10	70333405	70333405	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttccttcctgttcctcCaaatccaattgctaccttta	7	17	3	14	0	1	0	0	0	1	0	6	0	6	0	6	0	2	2	6	0	4	7			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr10:70333405C>T	uc001jok.3	+	2	1815	c.1310C>T	c.(1309-1311)CCA>CTA	p.P437L		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	437					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						CCTGTTCCTCCAAATCCAATT	0.468													27	102					0	0	0	0	T	70333405	T	T	70333405	3	4	267	1	0	0	0	0	1	0	0	0	15835	594	21	4	1312	4	TET1	10	70333405	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	6185208	70333405	65201342	53	48552											
AVPI1	60370	broad.mit.edu	37	chr10	99437758	99437758	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcactctgtgggttggcCagtgcagagtggggctccag	5	9	18	9	0	1	1	0	0	1	1	2	1	2	1	2	5	1	4	2	5	0	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr10:99437758C>T	uc001koh.1	-	3	423	c.312G>A	c.(310-312)CTG>CTA	p.L104L	AVPI1_uc001koi.2_Silent_p.L104L	NM_021732	NP_068378	Q5T686	AVPI1_HUMAN	vasopressin-induced protein, 32kDa	104					cell cycle					breast(1)	1		Colorectal(252;0.162)		Epithelial(162;8.37e-11)|all cancers(201;7.94e-09)		GTGGGTTGGCCAGTGCAGAGT	0.522													26	62					0	0	0	0	T	99437758	T	T	99437758	2	4	267	1	0	0	0	0	0	0	0	1	1232	581	21	4		4	AVPI1	10	99437758	Silent	SNP	C	TCGA-CV-7435-01A-11D-2129-08	29104353	99437758	36096989	54	48553											
C10orf125	282969	broad.mit.edu	37	chr10	135168929	135168929	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggatgaggtttccgtagAgggccgtctccctgcagagg	7	9	16	9	2	1	4	0	2	1	2	3	5	2	5	3	4	1	3	3	4	1	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr10:135168929A>T	uc001lmt.2	-	6	428	c.410T>A	c.(409-411)CTC>CAC	p.L137H	C10orf125_uc001lms.2_3'UTR	NM_001098483	NP_001091953	A2VDF0	FUCM_HUMAN	hypothetical protein LOC282969 isoform 1	137					fucose metabolic process		fucose binding|racemase and epimerase activity, acting on carbohydrates and derivatives				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;6.94e-06)|OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)		GTTTCCGTAGAGGGCCGTCTC	0.662													5	22					0	0	0	0	T	135168929	T	T	135168929	3	4	267	1	0	0	0	0	1	0	0	0	1597	304	11	5	58	5	C10orf125	10	135168929	Missense_Mutation	SNP	A	TCGA-CV-7435-01A-11D-2129-08	35731171	135168929	365818	55	48554											
LUZP2	338645	broad.mit.edu	37	chr11	24750809	24750809	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaagacatcaagagaacttGatggaattaaagtcaatctt	18	10	7	6	0	3	3	2	1	1	2	3	5	3	4	0	1	1	0	0	1	7	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr11:24750809G>A	uc001mqs.2	+	2	391	c.157G>A	c.(157-159)GAT>AAT	p.D53N	LUZP2_uc009yif.2_5'UTR|LUZP2_uc009yig.2_Missense_Mutation_p.D53N	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	53	Potential.					extracellular region				ovary(1)|skin(1)	2						AAGAGAACTTGATGGAATTAA	0.403													4	62					0	0	0	0	A	24750809	A	A	24750809	3	1	267	1	0	0	0	0	1	0	0	0	9137	1290	45	2	163	2	LUZP2	11	24750809	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08		24750809	110255707	56	48555											
LGALS12	85329	broad.mit.edu	37	chr11	63276452	63276452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctctttctcttcgggaatGaggaagtgaaggtgaaggaa	11	11	13	6	1	2	3	0	3	2	0	5	6	3	6	1	4	0	0	1	4	5	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr11:63276452G>A	uc001nxa.2	+	3	768	c.427G>A	c.(427-429)GAG>AAG	p.E143K	LGALS12_uc001nxb.2_Missense_Mutation_p.E143K|LGALS12_uc001nxc.2_Missense_Mutation_p.E144K|LGALS12_uc001nxd.2_Missense_Mutation_p.E82K|LGALS12_uc001nxe.2_Missense_Mutation_p.E82K|LGALS12_uc009yot.2_Missense_Mutation_p.E103K	NM_033101	NP_149092	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12 isoform	143	Galectin 1.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			ovary(2)	2						CTTCGGGAATGAGGAAGTGAA	0.592													10	27					0	0	0	0	A	63276452	A	A	63276452	3	1	267	1	0	0	0	0	1	0	0	0	8779	1291	45	2	440	2	LGALS12	11	63276452	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	38525643	63276452	71730064	57	48556											
SLC29A2	3177	broad.mit.edu	37	chr11	66134014	66134014	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagagctactttctggggaCtactgggaatcccgttctca	8	12	10	11	1	3	1	2	0	2	1	5	3	4	3	1	3	3	2	1	3	3	4			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr11:66134014C>T	uc001oht.2	-	8	984	c.755G>A	c.(754-756)AGT>AAT	p.S252N	SLC29A2_uc001ohs.2_Missense_Mutation_p.S132N|SLC29A2_uc010rpb.1_RNA|SLC29A2_uc009yrf.2_Missense_Mutation_p.S132N|SLC29A2_uc001ohu.2_Missense_Mutation_p.S252N|SLC29A2_uc001ohv.2_Intron|uc001ohw.1_5'Flank	NM_001532	NP_001523	Q14542	S29A2_HUMAN	solute carrier family 29 (nucleoside	252					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1						TTTCTGGGGACTACTGGGAAT	0.577													7	52					0	0	0	0	T	66134014	T	T	66134014	3	4	267	1	0	0	0	0	1	0	0	0	14599	565	20	4	635	4	SLC29A2	11	66134014	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	2857562	66134014	68872502	58	48557											
GRM5	2915	broad.mit.edu	37	chr11	88242175	88242175	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacagcatcatggagttgAgctcgctgatgttggccgtg	7	11	15	8	2	1	2	1	2	0	0	2	4	1	4	1	3	2	5	1	3	0	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	f2192c96-2c1b-435a-ba30-a29247b9f1b7	g.chr11:88242175A>T	uc001pcq.2	-	9	3424	c.3224T>A	c.(3223-3225)CTC>CAC	p.L1075H	GRM5_uc009yvm.2_Missense_Mutation_p.L1043H	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	1075	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CATGGAGTTGAGCTCGCTGAT	0.667													3	7					0	0	0	0	T	88242175	T	T	88242175	3	4	267	1	0	0	0	0	1	0	0	0	6839	304	11	5	418	5	GRM5	11	88242175	Missense_Mutation	SNP	A	TCGA-CV-7435-01A-11D-2129-08	22108161	88242175	46764341	59	48558											
FAM90A1	55138	broad.mit.edu	37	chr12	8380429	8380429	+	5'Flank	DEL	C	-	-																															ggctggagggccgaggactaCccccgcttctaggtgagagg																										TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr12:8380429delC	uc001qui.2	-						FAM90A1_uc001quh.2_5'Flank	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138								nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		CCGAGGACTACCCCCGCTTCT	0.607													---	---	---								-	8380429	-	-	8380429	6	5	267	0	1	1	0	1	0	0	0	0	5682	522	18	0		0	FAM90A1	12	8380429	5'Flank	DEL	C	TCGA-CV-7435-01A-11D-2129-08		8380429	125471466	60	48559											
PPFIBP1	8496	broad.mit.edu	37	chr12	27829391	27829391	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggcagaaagcaggccatttGggacccttcctcccaggccc	8	6	11	16	1	0	1	0	0	0	1	2	2	2	2	5	4	1	2	5	4	1	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr12:27829391G>T	uc001ric.1	+	18	1869	c.1492G>T	c.(1492-1494)GGG>TGG	p.G498W	PPFIBP1_uc010sjr.1_Missense_Mutation_p.G329W|PPFIBP1_uc001rib.1_Missense_Mutation_p.G481W|PPFIBP1_uc001ria.2_Missense_Mutation_p.G467W|PPFIBP1_uc001rid.1_Missense_Mutation_p.G345W|PPFIBP1_uc001rif.1_5'Flank	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	498					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					CAGGCCATTTGGGACCCTTCC	0.552													11	227					7.03913e-09	7.9867e-09	1	0	T	27829391	T	T	27829391	3	4	267	1	0	0	0	0	1	0	0	0	12368	1348	47	4	1545	4	PPFIBP1	12	27829391	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	19448962	27829391	106022504	61	48560											
SENP1	29843	broad.mit.edu	37	chr12	48468185	48468185	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atgatggggatgatgaagagTaccagaatctttggatccaa	14	10	12	5	0	1	5	0	3	1	2	2	7	2	7	2	3	1	1	2	3	4	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr12:48468185T>C	uc001rqx.2	-	8	1308	c.862A>G	c.(862-864)ACT>GCT	p.T288A	SENP1_uc001rqw.2_Missense_Mutation_p.T288A|SENP1_uc001rqy.2_Missense_Mutation_p.T89A|SENP1_uc001rqz.2_Missense_Mutation_p.T89A|SENP1_uc009zkx.2_Missense_Mutation_p.T288A	NM_014554	NP_055369	Q9P0U3	SENP1_HUMAN	sentrin/SUMO-specific protease 1	288					activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			pancreas(2)|lung(1)	3		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				TGATGAAGAGTACCAGAATCT	0.408													18	98					0	0	0	0	C	48468185	C	C	48468185	3	2	267	1	0	0	0	0	1	0	0	0	14111	1638	57	5	1113	5	SENP1	12	48468185	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08	20638794	48468185	85383710	62	48561											
MLL2	8085	broad.mit.edu	37	chr12	49446699	49446699	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagtccccaccacttaccTgctacacaccggggtatgct	8	9	8	16	1	1	0	1	0	0	0	2	0	2	0	5	2	4	3	5	2	3	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr12:49446699T>C	uc001rta.3	-	8	1111	c.1111A>G	c.(1111-1113)AGA>GGA	p.R371G		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	371					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ACCACTTACCTGCTACACACC	0.547			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			30	91					0	0	0	0	C	49446699	C	C	49446699	3	2	267	1	0	0	0	0	1	0	0	0	9674	1594	55	5	15690	5	MLL2	12	49446699	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08	978514	49446699	84405196	63	48562											
AQP6	363	broad.mit.edu	37	chr12	50367087	50367087	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgttctttggcgtgggctCagtcatgcgctggcccacag	4	12	14	11	2	3	0	2	0	1	0	3	0	3	0	1	3	1	3	1	3	0	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr12:50367087C>T	uc001rvr.1	+	1	468	c.131C>T	c.(130-132)TCA>TTA	p.S44L	AQP6_uc001rvp.1_Intron|AQP6_uc001rvq.1_RNA	NM_001652	NP_001643	Q13520	AQP6_HUMAN	aquaporin 6	44	Helical; (Potential).				excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity				0						GGCGTGGGCTCAGTCATGCGC	0.607													23	80					0	0	0	0	T	50367087	T	T	50367087	3	4	267	1	0	0	0	0	1	0	0	0	830	838	29	2	133	2	AQP6	12	50367087	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	920388	50367087	83484808	64	48563											
ATF7	11016	broad.mit.edu	37	chr12	53994854	53994854	+	5'Flank	DEL	A	-	-																															tatgttaaatatgctggagcAaaaaaaaaaaaaaagtgctt																										TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr12:53994854delA	uc001sdy.2	-						ATF7_uc010sok.1_Intron|ATF7_uc001sdz.2_Intron|ATF7_uc010sol.1_Intron|ATF7_uc001sea.3_Intron|ATF7_uc001seb.3_Intron	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1						interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						ATGCTGGAGCAAAAAAAAAAA	0.418													---	---	---								-	53994854	-	-	53994854	6	5	267	0	1	1	0	1	0	0	0	0	1088	145	5	0		0	ATF7	12	53994854	5'Flank	DEL	A	TCGA-CV-7435-01A-11D-2129-08	3627767	53994854	79857041	65	48564											
BBS10	79738	broad.mit.edu	37	chr12	76741323	76741323	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaaaagtgtctacttaggtActggtccataataccgtcta	13	12	7	9	1	2	0	0	0	2	0	3	0	3	0	2	2	3	1	2	2	8	6			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr12:76741323A>T	uc001syd.1	-	2	526	c.442T>A	c.(442-444)TAC>AAC	p.Y148N		NM_024685	NP_078961	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	148					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			ovary(1)|skin(1)	2						CTACTTAGGTACTGGTCCATA	0.393									Bardet-Biedl_syndrome				11	65					0	0	0	0	T	76741323	T	T	76741323	3	4	267	1	0	0	0	0	1	0	0	0	1338	391	14	5	1733	5	BBS10	12	76741323	Missense_Mutation	SNP	A	TCGA-CV-7435-01A-11D-2129-08	22746469	76741323	57110572	66	48565											
HAL	3034	broad.mit.edu	37	chr12	96377733	96377733	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtggtaatgatgttctTcacaaatgctattgtatcat	10	18	7	6	0	4	1	2	1	2	0	4	1	4	1	0	1	1	4	0	1	4	7			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr12:96377733T>C	uc001tem.1	-	15	1540	c.1243A>G	c.(1243-1245)AAG>GAG	p.K415E	HAL_uc009zti.1_RNA|HAL_uc010suw.1_Missense_Mutation_p.K207E|HAL_uc010sux.1_Missense_Mutation_p.K415E	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	415					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	ATGATGTTCTTCACAAATGCT	0.338													21	39					0	0	0	0	C	96377733	C	C	96377733	3	2	267	1	0	0	0	0	1	0	0	0	6986	1792	62	5	758	5	HAL	12	96377733	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08	19636410	96377733	37474162	67	48566											
DHRS1	115817	broad.mit.edu	37	chr14	24760813	24760813	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caattctgtggtttccgcagAtgagaaggctgatttgaact	10	13	11	7	1	1	4	0	3	1	2	2	5	2	4	1	2	1	3	1	2	3	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr14:24760813A>G	uc001woj.1	-	7	942	c.673T>C	c.(673-675)TCT>CCT	p.S225P	DHRS1_uc010aln.1_Intron|DHRS1_uc001wok.2_Missense_Mutation_p.S225P	NM_138452	NP_612461	Q96LJ7	DHRS1_HUMAN	dehydrogenase/reductase (SDR family) member 1	225						endoplasmic reticulum	binding|oxidoreductase activity				0				GBM - Glioblastoma multiforme(265;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(311;0.0442)		GTTTCCGCAGATGAGAAGGCT	0.488													34	218					0	0	0	0	G	24760813	G	G	24760813	3	3	267	1	0	0	0	0	1	0	0	0	4508	333	12	5	280	5	DHRS1	14	24760813	Missense_Mutation	SNP	A	TCGA-CV-7435-01A-11D-2129-08		24760813	82588727	68	48567											
SYT16	83851	broad.mit.edu	37	chr14	62567240	62567240	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttccaggtggccctctttCagctgtctgatgtcacgttg	4	16	10	11	1	4	1	2	1	2	0	5	1	5	1	2	2	1	2	2	2	0	4			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr14:62567240C>T	uc001xfu.1	+	6	1950	c.1753C>T	c.(1753-1755)CAG>TAG	p.Q585*	SYT16_uc010tse.1_Nonsense_Mutation_p.Q143*	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	585	C2 2.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GGCCCTCTTTCAGCTGTCTGA	0.502													15	31					0	0	0	0	T	62567240	T	T	62567240	4	4	267	1	0	0	0	0	0	1	0	0	15538	827	29	2	1775	2	SYT16	14	62567240	Nonsense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	37806427	62567240	44782300	69	48568											
SYNE2	23224	broad.mit.edu	37	chr14	64496627	64496627	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttaggattctgtgcaaaaCttggacggtcacgttcgaga	10	13	11	7	3	2	1	1	0	1	1	3	4	2	3	0	3	2	2	0	3	3	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr14:64496627C>G	uc001xgm.2	+	44	6959	c.6729C>G	c.(6727-6729)AAC>AAG	p.N2243K	SYNE2_uc001xgl.2_Missense_Mutation_p.N2243K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2243	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTGTGCAAAACTTGGACGGTC	0.338													5	25					0	0	0	0	G	64496627	G	G	64496627	3	3	267	1	0	0	0	0	1	0	0	0	15512	564	20	4	6899	4	SYNE2	14	64496627	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	1929387	64496627	42852913	70	48569											
MTFMT	123263	broad.mit.edu	37	chr15	65313852	65313852	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatattggggaattatacCatgttggcacccagtcttga	11	12	11	7	0	1	1	0	1	1	0	1	3	1	3	2	4	1	2	2	4	4	6			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr15:65313852C>A	uc002aof.3	-	4	671	c.645G>T	c.(643-645)ATG>ATT	p.M215I		NM_139242	NP_640335	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	215						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			ovary(2)	2					Tetrahydrofolic acid(DB00116)	GGAATTATACCATGTTGGCAC	0.383													20	50					1.01871e-10	1.17851e-10	1	0	A	65313852	A	A	65313852	3	1	267	1	0	0	0	0	1	0	0	0	9977	608	21	4	548	4	MTFMT	15	65313852	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08		65313852	37217540	71	48570											
RGS11	8786	broad.mit.edu	37	chr16	321023	321023	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aagtccatgaagtgggcccgCcccacggggtcctccaggag	8	5	14	14	2	0	1	0	1	0	0	3	2	3	2	6	4	0	0	6	4	2	0			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr16:321023C>A	uc002cgj.1	-	13	942	c.939G>T	c.(937-939)GGG>GGT	p.G313G	RGS11_uc002cgi.1_Silent_p.G292G|RGS11_uc010bqs.1_Silent_p.G302G|RGS11_uc002cgk.1_Silent_p.G129G	NM_183337	NP_899180	O94810	RGS11_HUMAN	regulator of G-protein signalling 11 isoform 1	313	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			lung(1)|pancreas(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				AGTGGGCCCGCCCCACGGGGT	0.682													3	36					0.00024832	0.00026398	1	0	A	321023	A	A	321023	2	1	267	1	0	0	0	0	0	0	0	1	13359	726	26	4		4	RGS11	16	321023	Silent	SNP	C	TCGA-CV-7435-01A-11D-2129-08		321023	90033730	72	48571											
SRRM2	23524	broad.mit.edu	37	chr16	2812431	2812431	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgatcaccagtacgacgcagGtctcgtagtagatcaccagc	11	7	10	13	4	3	1	2	0	1	1	4	3	3	1	2	1	2	4	2	1	3	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr16:2812431G>T	uc002crk.2	+	11	2451	c.1902G>T	c.(1900-1902)AGG>AGT	p.R634S	SRRM2_uc002crj.1_Missense_Mutation_p.R538S|SRRM2_uc002crl.1_Missense_Mutation_p.R634S|SRRM2_uc010bsu.1_Missense_Mutation_p.R538S	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	634	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TACGACGCAGGTCTCGTAGTA	0.622													22	80					3.5997e-14	4.20559e-14	1	0	T	2812431	T	T	2812431	3	4	267	1	0	0	0	0	1	0	0	0	15235	1252	44	4	1940	4	SRRM2	16	2812431	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	2491408	2812431	87542322	73	48572											
ACSM2A	123876	broad.mit.edu	37	chr16	20480920	20480920	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctaaggccaaggctattgttGctggggatgaagtcatccaa	11	10	12	8	0	1	1	1	1	0	0	2	2	2	2	2	4	1	3	2	4	5	4			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr16:20480920G>T	uc010bwe.2	+	5	714	c.475G>T	c.(475-477)GCT>TCT	p.A159S	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Missense_Mutation_p.A80S|ACSM2A_uc002dhf.3_Missense_Mutation_p.A159S|ACSM2A_uc002dhg.3_Missense_Mutation_p.A159S|ACSM2A_uc010vay.1_Missense_Mutation_p.A80S	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	159					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GGCTATTGTTGCTGGGGATGA	0.458													52	128					2.76378e-25	3.26127e-25	1	0	T	20480920	T	T	20480920	3	4	267	1	0	0	0	0	1	0	0	0	183	1319	46	4	485	4	ACSM2A	16	20480920	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	17668489	20480920	69873833	74	48573											
DNAH3	55567	broad.mit.edu	37	chr16	21069448	21069448	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttgggacacctcctgggTccaaaagatggaggagacac	11	6	14	10	0	0	2	0	0	0	2	2	5	2	4	3	5	0	1	3	5	2	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr16:21069448T>A	uc010vbe.1	-	27	3883	c.3883A>T	c.(3883-3885)ACC>TCC	p.T1295S		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1295	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ACCTCCTGGGTCCAAAAGATG	0.478													16	36					0	0	0	0	A	21069448	A	A	21069448	3	1	267	1	0	0	0	0	1	0	0	0	4625	1667	58	5	8610	5	DNAH3	16	21069448	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08	588528	21069448	69285305	75	48574											
GTF3C1	2975	broad.mit.edu	37	chr16	27476027	27476027	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctggcctgggggtcttctCtctggatgtcggcgtcttct	1	15	14	11	2	6	0	0	0	6	0	8	1	6	1	1	5	0	0	1	5	0	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr16:27476027C>G	uc002dov.1	-	34	5526	c.5486G>C	c.(5485-5487)AGA>ACA	p.R1829T	GTF3C1_uc002dou.2_Missense_Mutation_p.R1829T	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1829						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GGGGTCTTCTCTCTGGATGTC	0.672													17	69					0	0	0	0	G	27476027	G	G	27476027	3	3	267	1	0	0	0	0	1	0	0	0	6911	913	32	2	859	2	GTF3C1	16	27476027	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	6406579	27476027	62878726	76	48575											
CNOT1	23019	broad.mit.edu	37	chr16	58592411	58592411	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaagtcctccaataccactGaatgcagtggtctgattggg	11	10	11	9	0	1	2	0	2	1	0	3	3	3	2	3	2	2	1	3	2	4	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr16:58592411G>T	uc002env.2	-	18	2591	c.2298C>A	c.(2296-2298)TTC>TTA	p.F766L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.F766L|CNOT1_uc002enx.2_Missense_Mutation_p.F766L|CNOT1_uc002enz.1_Missense_Mutation_p.F195L	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	766					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CAATACCACTGAATGCAGTGG	0.463													10	35					6.40141e-05	6.92997e-05	1	0	T	58592411	T	T	58592411	3	4	267	1	0	0	0	0	1	0	0	0	3632	1281	45	2	5182	2	CNOT1	16	58592411	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	31116384	58592411	31762342	77	48576											
TP53	7157	broad.mit.edu	37	chr17	7578190	7578190	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accagacctcaggcggctcaTagggcaccaccacactatgt	11	6	9	15	1	2	1	2	0	0	1	2	1	2	1	4	3	0	2	4	3	2	2	rs121912666		TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr17:7578190T>C	uc002gim.2	-	6	853	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	TP53_uc002gig.1_Missense_Mutation_p.Y220C|TP53_uc002gih.2_Missense_Mutation_p.Y220C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y88C|TP53_uc010cng.1_Missense_Mutation_p.Y88C|TP53_uc002gii.1_Missense_Mutation_p.Y88C|TP53_uc010cnh.1_Missense_Mutation_p.Y220C|TP53_uc010cni.1_Missense_Mutation_p.Y220C|TP53_uc002gij.2_Missense_Mutation_p.Y220C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y127C|TP53_uc002gio.2_Missense_Mutation_p.Y88C|TP53_uc010vug.1_Missense_Mutation_p.Y181C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	220	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(205)|p.Y220N(12)|p.Y220H(9)|p.Y220S(9)|p.0?(7)|p.Y220fs*27(4)|p.Y220*(3)|p.Y220D(2)|p.Y127C(2)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.?(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*1(1)|p.Y220fs*2(1)|p.V218fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	20					0	0	0	0	C	7578190	C	C	7578190	3	2	267	1	0	0	0	0	1	0	0	0	16448	1406	49	5	635	5	TP53	17	7578190	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08		7578190	73617020	78	48577											
DNAH2	146754	broad.mit.edu	37	chr17	7734767	7734767	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaaatgatcgactatgagggGactcaaaaactgctagctct	14	9	10	8	1	2	2	1	2	1	0	3	5	2	3	0	2	3	2	0	2	5	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr17:7734767G>C	uc002giu.1	+	80	12533	c.12519G>C	c.(12517-12519)GGG>GGC	p.G4173G	DNAH2_uc010cnm.1_Silent_p.G1111G	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4173					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACTATGAGGGGACTCAAAAAC	0.527													12	37					0	0	0	0	C	7734767	C	C	7734767	2	2	267	1	0	0	0	0	0	0	0	1	4624	1161	41	2		2	DNAH2	17	7734767	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08	156577	7734767	73460443	79	48578											
RNF135	84282	broad.mit.edu	37	chr17	29326075	29326075	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgaggagggaaagcttgccTtctattcagtggacaatcag	11	11	12	7	0	3	1	2	1	1	0	3	4	3	4	1	3	2	1	1	3	3	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr17:29326075T>C	uc002hfz.2	+	5	1301	c.1165T>C	c.(1165-1167)TTC>CTC	p.F389L	RNF135_uc002hga.2_3'UTR|RNF135_uc010csm.2_3'UTR|RNF135_uc002hgb.2_3'UTR	NM_032322	NP_115698	Q8IUD6	RN135_HUMAN	ring finger protein 135 isoform 1	389	B30.2/SPRY.				innate immune response|negative regulation of type I interferon production|positive regulation of interferon-beta production|regulation of innate immune response	cytosol	protein binding|ribonucleoprotein binding|ubiquitin-protein ligase activity|zinc ion binding	p.?(1)		skin(2)	2		all_cancers(10;8.65e-08)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Myeloproliferative disorder(56;0.0255)				AAAGCTTGCCTTCTATTCAGT	0.532													25	71					0	0	0	0	C	29326075	C	C	29326075	3	2	267	1	0	0	0	0	1	0	0	0	13505	1609	56	5	1252	5	RNF135	17	29326075	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08	21591308	29326075	51869135	80	48579											
MED13	9969	broad.mit.edu	37	chr17	60032881	60032881	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttagctgagatgtctgcaTatttagagtcgtgcttcttc	8	17	9	7	1	2	2	0	1	2	2	4	3	2	2	0	0	3	3	0	0	3	7			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr17:60032881T>A	uc002izo.2	-	26	5907	c.5830A>T	c.(5830-5832)ATG>TTG	p.M1944L		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1944					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GATGTCTGCATATTTAGAGTC	0.343													23	134					0	0	0	0	A	60032881	A	A	60032881	3	1	267	1	0	0	0	0	1	0	0	0	9483	1406	49	5	714	5	MED13	17	60032881	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08	30706806	60032881	21162329	81	48580											
SLC26A11	284129	broad.mit.edu	37	chr17	78223009	78223009	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtctgcagcatcgactacActgtggtgctgggactcggc	7	10	13	11	2	1	0	0	0	1	0	3	2	1	1	0	3	4	3	0	3	1	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr17:78223009A>G	uc002jyb.1	+	16	1848	c.1579A>G	c.(1579-1581)ACT>GCT	p.T527A	SLC26A11_uc002jyc.1_Missense_Mutation_p.T527A|SLC26A11_uc002jyd.1_Missense_Mutation_p.T527A|SLC26A11_uc010dhv.1_Missense_Mutation_p.T527A	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	527	Extracellular (Potential).|STAS.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CATCGACTACACTGTGGTGCT	0.672													5	25					0	0	0	0	G	78223009	G	G	78223009	3	3	267	1	0	0	0	0	1	0	0	0	14580	159	6	5	1633	5	SLC26A11	17	78223009	Missense_Mutation	SNP	A	TCGA-CV-7435-01A-11D-2129-08	18190128	78223009	2972201	82	48581											
ROCK1	6093	broad.mit.edu	37	chr18	18534911	18534911	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagtgtaggaataaactcaTggcctttgtgattttggaaa	13	13	11	4	0	1	2	1	1	0	1	1	4	1	4	1	3	1	1	1	3	5	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr18:18534911T>C	uc002kte.2	-	31	4627	c.3686A>G	c.(3685-3687)CAT>CGT	p.H1229R		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1229	PH.|Auto-inhibitory.|Phorbol-ester/DAG-type.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					AATAAACTCATGGCCTTTGTG	0.413													11	37					0	0	0	0	C	18534911	C	C	18534911	3	2	267	1	0	0	0	0	1	0	0	0	13582	1464	51	5	390	5	ROCK1	18	18534911	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08		18534911	59542337	83	48582											
B4GALT6	9331	broad.mit.edu	37	chr18	29211087	29211087	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacattgaaaagcatcgcaCggttaaaaggttgtgtgcca	13	9	10	9	2	0	1	0	1	0	0	1	1	0	1	2	2	2	4	2	2	4	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr18:29211087C>T	uc002kwz.3	-	6	908	c.611G>A	c.(610-612)CGT>CAT	p.R204H	B4GALT6_uc010dma.2_Missense_Mutation_p.R165H|B4GALT6_uc010dmb.2_Missense_Mutation_p.R165H	NM_004775	NP_004766	Q9UBX8	B4GT6_HUMAN	beta-1,4-galactosyltransferase 6	204	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding				0			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			AAGCATCGCACGGTTAAAAGG	0.398													19	37					0	0	0	0	T	29211087	T	T	29211087	3	4	267	1	0	0	0	0	1	0	0	0	1277	536	19	1	553	1	B4GALT6	18	29211087	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	10676176	29211087	48866161	84	48583											
S1PR4	8698	broad.mit.edu	37	chr19	3179854	3179854	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccaccaccgacagctctcTgaggccaagggacagctttc	9	8	9	15	1	1	1	0	1	1	0	4	3	2	2	4	2	2	2	4	2	1	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr19:3179854T>A	uc002lxg.2	+	1	1089	c.1064T>A	c.(1063-1065)CTG>CAG	p.L355Q		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	355	Cytoplasmic (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						GACAGCTCTCTGAGGCCAAGG	0.682													30	89					0	0	0	0	A	3179854	A	A	3179854	3	1	267	1	0	0	0	0	1	0	0	0	13861	1580	55	5	1066	5	S1PR4	19	3179854	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08		3179854	55949129	85	48584											
MUC16	94025	broad.mit.edu	37	chr19	9073955	9073955	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaggttccatgcttgtgttCaacatatctgtggtcttcac	8	15	8	10	0	4	0	2	0	2	0	5	0	5	0	1	2	2	3	1	2	2	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr19:9073955C>G	uc002mkp.2	-	3	13695	c.13491G>C	c.(13489-13491)TTG>TTC	p.L4497F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4499	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGCTTGTGTTCAACATATCTG	0.453													28	76					0	0	0	0	G	9073955	G	G	9073955	3	3	267	1	0	0	0	0	1	0	0	0	10026	825	29	2	30360	2	MUC16	19	9073955	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	5894101	9073955	50055028	86	48585											
ZNF433	163059	broad.mit.edu	37	chr19	12126659	12126659	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gataatactttcccacaatgTttacattcatagggtttttt	11	18	5	7	0	1	0	1	0	0	0	2	1	2	0	1	1	2	2	1	1	5	10			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr19:12126659T>G	uc002msy.1	-	4	1194	c.1023A>C	c.(1021-1023)AAA>AAC	p.K341N	uc002msx.1_Intron|ZNF433_uc002msz.1_Missense_Mutation_p.K306N	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	341	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCCACAATGTTTACATTCAT	0.388													6	58					0	0	0	0	G	12126659	G	G	12126659	3	3	267	1	0	0	0	0	1	0	0	0	17974	1722	60	5	1002	5	ZNF433	19	12126659	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08	3052704	12126659	47002324	87	48586											
ZNF99	7652	broad.mit.edu	37	chr19	22940586	22940586	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctaaaagctttgccacattCttcacatttgtagggtttct	9	16	7	9	0	3	0	1	0	2	0	3	0	3	0	1	1	2	4	1	1	3	7			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr19:22940586C>G	uc010xrh.1	-	5	1852	c.1852G>C	c.(1852-1854)GAA>CAA	p.E618Q		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTGCCACATTCTTCACATTTG	0.373													16	38					0	0	0	0	G	22940586	G	G	22940586	3	3	267	1	0	0	0	0	1	0	0	0	18271	922	32	2	1272	2	ZNF99	19	22940586	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	10813927	22940586	36188397	88	48587											
SARS2	54938	broad.mit.edu	37	chr19	39422789	39422789	+	5'Flank	DEL	A	-	-																															ttgtctcaaaaaaaaaaaagAaaaaaaaaaaaaaggtaatg																								rs59452154		TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr19:39422789delA	uc002oka.2	-						SARS2_uc002ojz.2_5'Flank|SARS2_uc010xup.1_5'Flank|SARS2_uc002okb.2_5'Flank|SARS2_uc010xuq.1_Intron|SARS2_uc010xur.1_5'Flank|SARS2_uc010xus.1_5'Flank|MRPS12_uc002okc.2_Intron|MRPS12_uc002okd.2_Intron|MRPS12_uc002oke.2_Intron	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor						seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			aaaaaaaaagaaaaaaaaaaa	0.134													---	---	---								-	39422789	-	-	39422789	6	5	267	0	1	1	0	1	0	0	0	0	13910	261	9	0		0	SARS2	19	39422789	5'Flank	DEL	A	TCGA-CV-7435-01A-11D-2129-08	16482203	39422789	19706194	89	48588											
CEACAM21	90273	broad.mit.edu	37	chr19	42085740	42085740	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccctccatccaagccagcagCaccacagtcacagagaaggg	13	3	9	16	0	1	1	1	0	0	1	3	2	3	1	5	1	3	2	5	1	2	0			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr19:42085740C>A	uc002ore.3	+	3	555	c.459C>A	c.(457-459)AGC>AGA	p.S153R	CEACAM21_uc002orc.1_RNA|CEACAM21_uc002ord.1_RNA|CEACAM21_uc002orf.2_RNA|CEACAM21_uc002org.3_Missense_Mutation_p.S153R	NM_001098506	NP_001091976	Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion	153	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1						AAGCCAGCAGCACCACAGTCA	0.537													6	75					8.12818e-05	8.71932e-05	1	0	A	42085740	A	A	42085740	3	1	267	1	0	0	0	0	1	0	0	0	3207	709	25	4	469	4	CEACAM21	19	42085740	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	2662951	42085740	17043243	90	48589											
LILRB4	11006	broad.mit.edu	37	chr19	55174502	55174502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccatgatccccaccttcaCggctctgctctgcctcggtg	4	10	9	18	3	3	1	1	1	2	0	5	1	4	1	5	2	2	2	5	2	0	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr19:55174502C>T	uc002qgp.2	+	1	379	c.17C>T	c.(16-18)ACG>ATG	p.T6M	LILRB4_uc002qgo.1_Missense_Mutation_p.T47M|LILRB4_uc002qgq.2_Missense_Mutation_p.T6M|LILRB4_uc010ers.1_Translation_Start_Site|LILRB4_uc002qgr.2_Missense_Mutation_p.T47M|LILRB4_uc010ert.2_Missense_Mutation_p.T47M|LILRB4_uc010eru.2_Missense_Mutation_p.T47M	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	6						integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		CCCACCTTCACGGCTCTGCTC	0.602											OREG0003670	type=REGULATORY REGION|Gene=LILRB4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	105					0	0	0	0	T	55174502	T	T	55174502	3	4	267	1	0	0	0	0	1	0	0	0	8834	536	19	1	19	1	LILRB4	19	55174502	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	13088762	55174502	3954481	91	48590											
ZMYND8	23613	broad.mit.edu	37	chr20	45875011	45875011	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctccagggtctgccttctcGctggctggtgacgtgctttt	2	14	13	12	2	2	1	0	1	2	0	4	1	3	1	2	3	2	4	2	3	0	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr20:45875011G>A	uc002xta.1	-	14	2219	c.1965C>T	c.(1963-1965)AGC>AGT	p.S655S	ZMYND8_uc010ghq.1_Silent_p.S332S|ZMYND8_uc010ghr.1_Silent_p.S630S|ZMYND8_uc002xst.1_Silent_p.S583S|ZMYND8_uc002xsu.1_Silent_p.S655S|ZMYND8_uc002xsv.1_Silent_p.S583S|ZMYND8_uc002xsw.1_Silent_p.S407S|ZMYND8_uc002xsx.1_Silent_p.S407S|ZMYND8_uc002xsy.1_Silent_p.S630S|ZMYND8_uc002xsz.1_Silent_p.S592S|ZMYND8_uc010zxy.1_Silent_p.S682S|ZMYND8_uc002xtb.1_Silent_p.S675S|ZMYND8_uc002xss.2_Silent_p.S655S|ZMYND8_uc010zxz.1_Silent_p.S650S|ZMYND8_uc002xtc.1_Silent_p.S675S|ZMYND8_uc002xtd.1_Silent_p.S650S|ZMYND8_uc002xte.1_Silent_p.S655S|ZMYND8_uc010zya.1_Silent_p.S655S|ZMYND8_uc002xtf.1_Silent_p.S675S|ZMYND8_uc002xtg.2_Silent_p.S649S|ZMYND8_uc010ghs.1_Silent_p.S649S	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	655							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			CTGCCTTCTCGCTGGCTGGTG	0.502													39	194					0	0	0	0	A	45875011	A	A	45875011	2	1	267	1	0	0	0	0	0	0	0	1	17778	1078	38	1		1	ZMYND8	20	45875011	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08		45875011	17150509	92	48591											
GART	2618	broad.mit.edu	37	chr21	34897183	34897183	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttggcttcctcaagggctgaTatgagattttcccggatggc	7	13	12	9	1	1	2	1	2	0	1	3	4	3	3	2	4	0	2	2	4	2	5			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr21:34897183T>C	uc002yrx.2	-	11	1326	c.1191A>G	c.(1189-1191)ATA>ATG	p.I397M	GART_uc002yrz.2_Missense_Mutation_p.I397M|GART_uc010gmd.2_Missense_Mutation_p.I59M|GART_uc002yry.2_Missense_Mutation_p.I397M|GART_uc002ysa.2_Missense_Mutation_p.I397M	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	397					'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	CAAGGGCTGATATGAGATTTT	0.488													34	70					0	0	0	0	C	34897183	C	C	34897183	3	2	267	1	0	0	0	0	1	0	0	0	6278	1396	49	5	1893	5	GART	21	34897183	Missense_Mutation	SNP	T	TCGA-CV-7435-01A-11D-2129-08		34897183	13232712	93	48592											
LARGE	9215	broad.mit.edu	37	chr22	33780226	33780226	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccatgagctccctctctgcGgtcagcctccacatctgctc	5	10	7	19	1	3	1	1	1	2	0	7	1	5	1	4	1	4	2	4	1	0	0			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chr22:33780226G>A	uc003and.3	-	9	1536	c.957C>T	c.(955-957)ACC>ACT	p.T319T	LARGE_uc011amd.1_Silent_p.T118T|LARGE_uc003ane.3_Silent_p.T319T|LARGE_uc010gwp.2_Silent_p.T319T|LARGE_uc011ame.1_Silent_p.T251T|LARGE_uc011amf.1_Silent_p.T319T|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	319	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				CCCTCTCTGCGGTCAGCCTCC	0.512													6	152					0	0	0	0	A	33780226	A	A	33780226	2	1	267	1	0	0	0	0	0	0	0	1	8667	1103	39	1		1	LARGE	22	33780226	Silent	SNP	G	TCGA-CV-7435-01A-11D-2129-08		33780226	17524340	94	48593											
FANCB	2187	broad.mit.edu	37	chrX	14883285	14883285	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcaaacgcatttcaaatttAttagtactgtgaaggattag	14	14	7	6	1	2	1	2	1	0	0	2	2	2	2	0	1	2	2	0	1	7	6			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chrX:14883285A>G	uc004cwg.1	-	3	616	c.348T>C	c.(346-348)AAT>AAC	p.N116N	FANCB_uc004cwh.1_Silent_p.N116N	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	116					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					TTTCAAATTTATTAGTACTGT	0.318								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				15	48					0	0	0	0	G	14883285	G	G	14883285	2	3	267	1	0	0	0	0	0	0	0	1	5695	446	16	5		5	FANCB	23	14883285	Silent	SNP	A	TCGA-CV-7435-01A-11D-2129-08		14883285	140387275	95	48594											
CXorf21	80231	broad.mit.edu	37	chrX	30577998	30577998	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgggtaaaggaatctcagAtgacttcagcaaagggccat	14	8	11	8	0	2	2	2	1	1	1	3	3	2	3	1	3	1	2	1	3	4	2			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chrX:30577998A>T	uc004dcg.1	-	3	751	c.475T>A	c.(475-477)TCT>ACT	p.S159T		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	159										ovary(1)	1						GGAATCTCAGATGACTTCAGC	0.453													22	54					0	0	0	0	T	30577998	T	T	30577998	3	4	267	1	0	0	0	0	1	0	0	0	4118	333	12	5	434	5	CXorf21	23	30577998	Missense_Mutation	SNP	A	TCGA-CV-7435-01A-11D-2129-08	15694713	30577998	124692562	96	48595											
FAM47C	442444	broad.mit.edu	37	chrX	37026592	37026592	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcgaagcgcaagcacaggCgcctgaggttcccgcctgtg	7	6	14	14	5	0	1	0	1	0	0	2	2	1	1	3	2	2	3	3	2	2	1			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chrX:37026592C>T	uc004ddl.1	+	1	123	c.109C>T	c.(109-111)CGC>TGC	p.R37C		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	37										ovary(3)	3						CAAGCACAGGCGCCTGAGGTT	0.617													17	25					0	0	0	0	T	37026592	T	T	37026592	3	4	267	1	0	0	0	0	1	0	0	0	5603	768	27	1	111	1	FAM47C	23	37026592	Missense_Mutation	SNP	C	TCGA-CV-7435-01A-11D-2129-08	6448594	37026592	118243968	97	48596											
ZNF630	57232	broad.mit.edu	37	chrX	47918974	47918974	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atacatatggtttctctccaGtatgaattctttgatgtata	11	18	6	6	0	2	2	0	2	2	0	4	2	3	2	1	1	1	3	1	1	6	8			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chrX:47918974G>A	uc004div.3	-	5	1109	c.857C>T	c.(856-858)ACT>ATT	p.T286I	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.T162I	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						TTTCTCTCCAGTATGAATTCT	0.388													32	100					0	0	0	0	A	47918974	A	A	47918974	3	1	267	1	0	0	0	0	1	0	0	0	18121	1029	36	4	1120	4	ZNF630	23	47918974	Missense_Mutation	SNP	G	TCGA-CV-7435-01A-11D-2129-08	10892382	47918974	107351586	98	48597											
HEPH	9843	broad.mit.edu	37	chrX	65476116	65476116	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaacccatgggtcccaggAtccaggcagtattaacctac	11	7	10	13	0	0	0	0	0	0	0	2	1	2	1	4	4	3	3	4	4	4	3			TCGA-CV-7435-01A-11D-2129-08	TCGA-CV-7435-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	16b7fd85-3664-4c4a-9a43-48b107dbcf7f	87d31453-f5b2-412a-b996-83d5b9d233ec	g.chrX:65476116A>G	uc011moz.1	+	17	2909	c.2849A>G	c.(2848-2850)GAT>GGT	p.D950G	HEPH_uc004dwn.2_Missense_Mutation_p.D950G|HEPH_uc004dwo.2_Missense_Mutation_p.D680G|HEPH_uc010nkr.2_Missense_Mutation_p.D758G|HEPH_uc011mpa.1_Missense_Mutation_p.D950G|HEPH_uc010nks.2_Missense_Mutation_p.D239G	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	947	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						GGGTCCCAGGATCCAGGCAGT	0.413													23	87					0	0	0	0	G	65476116	G	G	65476116	3	3	267	1	0	0	0	0	1	0	0	0	7093	333	12	5	3068	5	HEPH	23	65476116	Missense_Mutation	SNP	A	TCGA-CV-7435-01A-11D-2129-08	17557142	65476116	89794444	99	48598											
KIAA1522	57648	broad.mit.edu	37	chr1	33235551	33235551	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggatgccgtacgcatcccCacagtggacggccgcccccg	6	4	13	18	6	0	0	0	0	0	0	1	2	1	2	6	3	2	2	6	3	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:33235551C>T	uc001bvv.2	+	6	730	c.594C>T	c.(592-594)CCC>CCT	p.P198P	KIAA1522_uc001bvu.1_Silent_p.P257P|KIAA1522_uc010ohm.1_Silent_p.P209P|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	198											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TACGCATCCCCACAGTGGACG	0.721													13	14					0	0	0	0	T	33235551	T	T	33235551	2	4	268	1	0	0	0	0	0	0	0	1	8277	581	21	4		4	KIAA1522	1	33235551	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08		33235551	216015070	1	48599											
NSUN4	387338	broad.mit.edu	37	chr1	46810800	46810800	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgacagaggggatatcagtCgcttccctcctgccaggtag	8	10	12	11	1	1	2	1	1	0	1	4	3	3	3	3	3	1	2	3	3	2	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:46810800C>T	uc001cpr.1	+	2	530	c.421C>T	c.(421-423)CGC>TGC	p.R141C	NSUN4_uc010omc.1_Missense_Mutation_p.R92C|NSUN4_uc009vyf.1_Silent_p.V41V|NSUN4_uc009vyg.1_Missense_Mutation_p.R92C|NSUN4_uc001cpt.1_RNA|NSUN4_uc001cps.1_Intron	NM_199044	NP_950245	Q96CB9	NSUN4_HUMAN	NOL1/NOP2/Sun domain family 4 protein	141							methyltransferase activity				0	Acute lymphoblastic leukemia(166;0.155)					GGATATCAGTCGCTTCCCTCC	0.567													16	55					0	0	0	0	T	46810800	T	T	46810800	3	4	268	1	0	0	0	0	1	0	0	0	10734	884	31	1	427	1	NSUN4	1	46810800	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	13575249	46810800	202439821	2	48600											
EPHX4	253152	broad.mit.edu	37	chr1	92495663	92495663	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggctgcgggattgcctgccCcgcctgatgctcacgctccg	4	8	13	16	4	1	1	1	1	0	0	2	2	2	2	5	2	4	3	5	2	0	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:92495663C>G	uc001don.2	+	1	131	c.27C>G	c.(25-27)CCC>CCG	p.P9P		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	9						integral to membrane	hydrolase activity			central_nervous_system(1)	1						ATTGCCTGCCCCGCCTGATGC	0.701													9	7					0	0	0	0	G	92495663	G	G	92495663	2	3	268	1	0	0	0	0	0	0	0	1	5206	610	22	4		4	EPHX4	1	92495663	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	45684863	92495663	156754958	3	48601											
KCNA3	3738	broad.mit.edu	37	chr1	111216794	111216794	+	Frame_Shift_Del	DEL	C	-	-																															cctggcgctggaagtcgcggCggggcaagggccgctcctcc																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:111216794delC	uc001dzv.1	-	1	862	c.638delG	c.(637-639)CGCfs	p.R213fs		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	213						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAGTCGCGGCGGGGCAAGGG	0.682													---	---	---								-	111216794	-	-	111216794	7	5	268	1	0	1	0	1	0	0	0	0	8043	768	27	0	1093	0	KCNA3	1	111216794	Frame_Shift_Del	DEL	C	TCGA-CV-7437-01A-21D-2129-08	18721131	111216794	138033827	4	48602											
NOTCH2	4853	broad.mit.edu	37	chr1	120467945	120467945	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tacttgcatgtcttgctgttCccctggcattcaaagttgtc	6	16	8	11	0	2	0	1	0	1	0	4	0	3	0	2	1	3	5	2	1	2	6			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:120467945C>T	uc001eik.2	-	25	4750	c.4494G>A	c.(4492-4494)GGG>GGA	p.G1498G		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1498	Negative regulatory region (NRR).|LNR 2.|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTTGCTGTTCCCCTGGCATT	0.498			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				27	466					0	0	0	0	T	120467945	T	T	120467945	2	4	268	1	0	0	0	0	0	0	0	1	10602	842	30	2		2	NOTCH2	1	120467945	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	9251151	120467945	128782676	5	48603											
PLEKHO1	51177	broad.mit.edu	37	chr1	150128284	150128284	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatgagaaaaatattcaaGaggtatttgacctgagtgac	17	10	10	4	0	1	6	1	4	0	3	1	7	1	6	1	1	0	1	1	1	6	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:150128284G>T	uc001ett.2	+	3	480	c.202G>T	c.(202-204)GAG>TAG	p.E68*	PLEKHO1_uc001etr.2_5'UTR|PLEKHO1_uc001ets.2_5'UTR|PLEKHO1_uc001etu.2_5'UTR	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	68	PH.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAATATTCAAGAGGTATTTGA	0.438													9	236					0.000673444	0.000693135	1	0	T	150128284	T	T	150128284	4	4	268	1	0	0	0	0	0	1	0	0	12139	943	33	2	212	2	PLEKHO1	1	150128284	Nonsense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	29660339	150128284	99122337	6	48604											
FLG	2312	broad.mit.edu	37	chr1	152281214	152281214	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtctgagtcttctgaatGtccctcactgtcactggcct	5	15	9	12	0	5	2	2	2	3	0	6	2	6	2	2	1	0	0	2	1	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:152281214G>T	uc001ezu.1	-	3	6184	c.6148C>A	c.(6148-6150)CAT>AAT	p.H2050N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2050	Ser-rich.|Filaggrin 12.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTTCTGAATGTCCCTCACTG	0.562									Ichthyosis				30	861					1.08312e-15	1.22198e-15	1	0	T	152281214	T	T	152281214	3	4	268	1	0	0	0	0	1	0	0	0	5954	1377	48	4	6041	4	FLG	1	152281214	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	2152930	152281214	96969407	7	48605											
RUSC1	23623	broad.mit.edu	37	chr1	155292476	155292476	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggatggagaagtgacgtcagCgaggagccggtgccccaccg	9	4	17	11	4	1	2	1	1	0	1	1	6	1	4	4	4	3	0	4	4	1	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:155292476C>T	uc001fkj.2	+	2	1141	c.912C>T	c.(910-912)AGC>AGT	p.S304S	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_5'Flank|C1orf104_uc001fki.2_Intron|RUSC1_uc001fkk.2_Silent_p.S304S|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank|RUSC1_uc001fkn.2_5'Flank|RUSC1_uc001fko.2_5'Flank|RUSC1_uc001fkr.2_5'Flank|RUSC1_uc001fks.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	304						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			GTGACGTCAGCGAGGAGCCGG	0.557													35	117					0	0	0	0	T	155292476	T	T	155292476	2	4	268	1	0	0	0	0	0	0	0	1	13815	767	27	1		1	RUSC1	1	155292476	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	3011262	155292476	93958145	8	48606											
CD247	919	broad.mit.edu	37	chr1	167400951	167400951	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcctgcatgtgaagggcGtcgtaggtgtccttggtggc	5	10	18	8	2	0	1	0	1	0	0	2	1	1	1	2	5	1	2	2	5	2	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:167400951G>A	uc001gei.3	-	8	607	c.462C>T	c.(460-462)GAC>GAT	p.D154D	CD247_uc001gej.3_Silent_p.D153D	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	154	ITAM 3.|Cytoplasmic (Potential).				interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			TGTGAAGGGCGTCGTAGGTGT	0.562													8	211					0	0	0	0	A	167400951	A	A	167400951	2	1	268	1	0	0	0	0	0	0	0	1	3003	1136	40	1		1	CD247	1	167400951	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	12108475	167400951	81849670	9	48607											
SERPINC1	462	broad.mit.edu	37	chr1	173881055	173881055	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggctgatactaacttggagGatttgttggcttttcgatag	8	16	12	5	1	0	1	0	1	0	0	1	4	0	3	0	4	2	3	0	4	3	8			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:173881055G>T	uc001gjt.2	-	3	625	c.506C>A	c.(505-507)TCC>TAC	p.S169Y		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	169					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	TAACTTGGAGGATTTGTTGGC	0.423													18	186					7.07596e-05	7.36905e-05	1	0	T	173881055	T	T	173881055	3	4	268	1	0	0	0	0	1	0	0	0	14174	1174	41	2	908	2	SERPINC1	1	173881055	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	6480104	173881055	75369566	10	48608											
PRG4	10216	broad.mit.edu	37	chr1	186275519	186275519	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	accagttgtagatgaagctgGaagtggattggacaatggtg	12	10	15	4	0	0	2	0	1	0	1	0	5	0	5	1	4	1	3	1	4	4	3	rs28698702		TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:186275519G>C	uc001gru.3	+	7	719	c.668G>C	c.(667-669)GGA>GCA	p.G223A	PRG4_uc001grt.3_Missense_Mutation_p.G182A|PRG4_uc009wyl.2_Missense_Mutation_p.G130A|PRG4_uc009wym.2_Missense_Mutation_p.G89A|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	223					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						GATGAAGCTGGAAGTGGATTG	0.393													57	206					0	0	0	0	C	186275519	C	C	186275519	3	2	268	1	0	0	0	0	1	0	0	0	12543	1174	41	2	690	2	PRG4	1	186275519	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	12394464	186275519	62975102	11	48609											
CFH	3075	broad.mit.edu	37	chr1	196642255	196642255	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aataatggtatgcaggaaggGagaatgggttgctcttaatc	13	11	13	4	0	1	1	0	0	1	1	2	3	1	2	0	4	2	4	0	4	6	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:196642255G>T	uc001gtj.3	+	2	446	c.206G>T	c.(205-207)GGA>GTA	p.G69V	CFH_uc001gti.3_Missense_Mutation_p.G69V|CFH_uc009wyw.2_Missense_Mutation_p.G69V|CFH_uc009wyx.2_Missense_Mutation_p.G69V	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	69	Sushi 1.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TGCAGGAAGGGAGAATGGGTT	0.363													69	44					2.72615e-36	3.28632e-36	1	0	T	196642255	T	T	196642255	3	4	268	1	0	0	0	0	1	0	0	0	3298	1174	41	2	212	2	CFH	1	196642255	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	10366736	196642255	52608366	12	48610											
AVPR1B	553	broad.mit.edu	37	chr1	206224960	206224960	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcaagtcttcattttttccCtgcgggaggtgatccagggc	6	13	11	11	1	3	1	2	1	1	0	5	2	5	2	2	3	1	0	2	3	1	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:206224960C>T	uc001hds.2	+	1	678	c.520C>T	c.(520-522)CTG>TTG	p.L174L		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	174	Extracellular (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CATTTTTTCCCTGCGGGAGGT	0.647													14	107					0	0	0	0	T	206224960	T	T	206224960	2	4	268	1	0	0	0	0	0	0	0	1	1234	680	24	4		4	AVPR1B	1	206224960	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	9582705	206224960	43025661	13	48611											
PGBD5	79605	broad.mit.edu	37	chr1	230468601	230468601	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcactcaccctgctgcaccGgggagtaggcgttggtcagg	6	7	15	13	3	2	0	2	0	0	0	2	1	2	1	2	5	2	5	2	5	1	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:230468601G>A	uc010pwb.1	-	5	1055	c.1055C>T	c.(1054-1056)CCG>CTG	p.P352L	PGBD5_uc001htv.2_Missense_Mutation_p.P451L	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	352						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		CTGCTGCACCGGGGAGTAGGC	0.627													33	63					0	0	0	0	A	230468601	A	A	230468601	3	1	268	1	0	0	0	0	1	0	0	0	11839	1116	39	1	324	1	PGBD5	1	230468601	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	24243641	230468601	18782020	14	48612											
PGBD2	267002	broad.mit.edu	37	chr1	249211729	249211729	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagccctcacagggcacaCtgtttaccaagccagacagg	11	7	10	13	0	1	2	1	1	0	1	1	2	1	2	3	2	3	2	3	2	2	3	rs75935520		TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr1:249211729C>G	uc001ifh.2	+	3	1093	c.946C>G	c.(946-948)CTG>GTG	p.L316V	PGBD2_uc001ifg.2_Missense_Mutation_p.L65V|PGBD2_uc009xhd.2_Missense_Mutation_p.L313V	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	316										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ACAGGGCACACTGTTTACCAA	0.512													82	33					0	0	0	0	G	249211729	G	G	249211729	3	3	268	1	0	0	0	0	1	0	0	0	11836	564	20	4	952	4	PGBD2	1	249211729	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	18743128	249211729	38892	15	48613											
OSR1	130497	broad.mit.edu	37	chr2	19552911	19552911	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtgccgcacctgtggtctCgcaggtggtcttgcctccgg	3	10	14	14	3	2	0	0	0	2	0	4	0	3	0	4	4	2	2	4	4	0	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:19552911C>T	uc002rdc.2	-	2	959	c.656G>A	c.(655-657)CGA>CAA	p.R219Q		NM_145260	NP_660303	Q8TAX0	OSR1_HUMAN	odd-skipped related 1	219	C2H2-type 2.				chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)				CCTGTGGTCTCGCAGGTGGTC	0.597													48	65					0	0	0	0	T	19552911	T	T	19552911	3	4	268	1	0	0	0	0	1	0	0	0	11347	884	31	1	152	1	OSR1	2	19552911	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08		19552911	223646462	16	48614											
PLEKHH2	130271	broad.mit.edu	37	chr2	43927243	43927243	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaggaacaagatagttcCtcggatgaactgaataaaaa	21	7	8	5	1	0	3	0	2	0	1	2	5	1	5	1	2	2	1	1	2	10	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:43927243C>T	uc010yny.1	+	8	1229	c.1146C>T	c.(1144-1146)TCC>TCT	p.S382S	PLEKHH2_uc002rte.3_Silent_p.S382S|PLEKHH2_uc002rtf.3_Silent_p.S381S	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	382						cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAGATAGTTCCTCGGATGAAC	0.403													51	63					0	0	0	0	T	43927243	T	T	43927243	2	4	268	1	0	0	0	0	0	0	0	1	12132	668	24	4		4	PLEKHH2	2	43927243	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	24374332	43927243	199272130	17	48615											
ABCG8	64241	broad.mit.edu	37	chr2	44078781	44078781	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgaggtcacggcggcaagatCaagtcaggccagatctggat	11	6	14	10	3	4	2	3	0	1	2	4	4	4	3	1	5	0	1	1	5	2	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:44078781C>G	uc002rtq.2	+	4	471	c.381C>G	c.(379-381)ATC>ATG	p.I127M	ABCG8_uc010yoa.1_Missense_Mutation_p.I127M	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	127	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GCGGCAAGATCAAGTCAGGCC	0.602													42	48					0	0	0	0	G	44078781	G	G	44078781	3	3	268	1	0	0	0	0	1	0	0	0	72	816	29	2	395	2	ABCG8	2	44078781	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	151538	44078781	199120592	18	48616											
ZNF514	84874	broad.mit.edu	37	chr2	95815442	95815442	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaggctctcccacattcaCtgcattcatagggcttttct	8	14	7	12	0	4	1	2	1	2	0	5	1	4	1	1	2	1	3	1	2	2	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:95815442C>A	uc002sue.1	-	5	1162	c.788G>T	c.(787-789)AGT>ATT	p.S263I	ZNF514_uc002sud.1_Missense_Mutation_p.S336I	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	263	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCCACATTCACTGCATTCATA	0.433													26	115					3.01185e-09	3.23223e-09	1	0	A	95815442	A	A	95815442	3	1	268	1	0	0	0	0	1	0	0	0	18026	565	20	4	418	4	ZNF514	2	95815442	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	51736661	95815442	147383931	19	48617			1	73		2	2	12	N	G_C	5.827326e-05
ZNF514	84874	broad.mit.edu	37	chr2	95815453	95815453	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacattcactgcattcataGggcttttctccagtatgagt	9	14	7	11	0	3	1	2	1	1	0	4	1	3	1	2	1	1	3	2	1	2	6	rs140564139		TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:95815453G>C	uc002sue.1	-	5	1151	c.777C>G	c.(775-777)CCC>CCG	p.P259P	ZNF514_uc002sud.1_Silent_p.P332P	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCATTCATAGGGCTTTTCTC	0.418													30	130					0	0	0	0	C	95815453	C	C	95815453	2	2	268	1	0	0	0	0	0	0	0	1	18026	987	35	4		4	ZNF514	2	95815453	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	11	95815453	147383920	20	48618			1	73		2	2	12	N	G_C	5.827326e-05
TUBA3E	112714	broad.mit.edu	37	chr2	130951598	130951598	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagctgagatgactggggCgtaggtggccagggggaagt	8	7	19	7	1	1	2	1	2	0	1	1	4	1	3	1	6	1	2	1	6	2	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:130951598C>T	uc002tqv.2	-	4	918	c.817G>A	c.(817-819)GCC>ACC	p.A273T		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	273					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					ATGACTGGGGCGTAGGTGGCC	0.597													32	199					0	0	0	0	T	130951598	T	T	130951598	3	4	268	1	0	0	0	0	1	0	0	0	16816	768	27	1	543	1	TUBA3E	2	130951598	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	35136145	130951598	112247775	21	48619											
BAZ2B	29994	broad.mit.edu	37	chr2	160204131	160204131	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgagttacttggttttcttCattttcattcagttcaataa	9	20	5	7	1	5	0	4	0	1	0	6	1	5	0	0	1	1	3	0	1	3	10			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:160204131C>T	uc002uao.2	-	31	5672	c.5320G>A	c.(5320-5322)GAA>AAA	p.E1774K	BAZ2B_uc002uap.2_Missense_Mutation_p.E1738K	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1774					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TGGTTTTCTTCATTTTCATTC	0.343													14	33					0	0	0	0	T	160204131	T	T	160204131	3	4	268	1	0	0	0	0	1	0	0	0	1334	835	29	2	1214	2	BAZ2B	2	160204131	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	29252533	160204131	82995242	22	48620											
TBR1	10716	broad.mit.edu	37	chr2	162274717	162274717	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatttctttctctaggaaatCgggtctatatgcatccggat	9	16	8	8	2	3	0	0	0	3	0	6	2	4	2	1	3	1	1	1	3	5	6			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:162274717C>T	uc002ubw.1	+	3	1155	c.853C>T	c.(853-855)CGG>TGG	p.R285W	TBR1_uc010foy.2_5'UTR	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	285	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						TCTAGGAAATCGGGTCTATAT	0.413													19	28					0	0	0	0	T	162274717	T	T	162274717	3	4	268	1	0	0	0	0	1	0	0	0	15713	875	31	1	863	1	TBR1	2	162274717	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	2070586	162274717	80924656	23	48621											
NFE2L2	4780	broad.mit.edu	37	chr2	178098962	178098962	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcgacttactccaagatctAtatcttgcctccaaagtatg	11	13	5	12	1	2	1	0	0	2	1	5	2	4	1	3	0	2	1	3	0	6	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:178098962A>G	uc002ulh.3	-	2	638	c.83T>C	c.(82-84)ATA>ACA	p.I28T	NFE2L2_uc002ulg.3_Missense_Mutation_p.I12T|NFE2L2_uc010zfa.1_Missense_Mutation_p.I12T|NFE2L2_uc002uli.3_Missense_Mutation_p.I12T|NFE2L2_uc010fra.2_Missense_Mutation_p.I12T|NFE2L2_uc010frb.2_Missense_Mutation_p.I12T	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	28					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCCAAGATCTATATCTTGCCT	0.358			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			19	14					0	0	0	0	G	178098962	G	G	178098962	3	3	268	1	0	0	0	0	1	0	0	0	10422	449	16	5	1750	5	NFE2L2	2	178098962	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08	15824245	178098962	65100411	24	48622											
TTN	7273	broad.mit.edu	37	chr2	179463494	179463494	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaattggatctctagcagtCgctgggtctgatggcagact	8	11	12	10	1	2	2	0	1	2	1	4	3	2	3	1	3	1	3	1	3	2	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:179463494C>T	uc010zfg.1	-	240	49463	c.49239G>A	c.(49237-49239)GCG>GCA	p.A16413A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.A10108A|TTN_uc010zfi.1_Silent_p.A10041A|TTN_uc010zfj.1_Silent_p.A9916A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17340							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTAGCAGTCGCTGGGTCTG	0.418													56	162					0	0	0	0	T	179463494	T	T	179463494	2	4	268	1	0	0	0	0	0	0	0	1	16803	871	31	1		1	TTN	2	179463494	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	1364532	179463494	63735879	25	48623											
BARD1	580	broad.mit.edu	37	chr2	215645436	215645436	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtacctggtgaaagactaaTgaattcatcggacatgttac	13	12	9	7	1	1	3	1	2	0	1	2	4	1	4	1	2	2	2	1	2	5	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:215645436T>C	uc002veu.2	-	4	1297	c.1162A>G	c.(1162-1164)ATT>GTT	p.I388V	BARD1_uc010zjm.1_Missense_Mutation_p.I244V	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	388					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GAAAGACTAATGAATTCATCG	0.423									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				6	114					0	0	0	0	C	215645436	C	C	215645436	3	2	268	1	0	0	0	0	1	0	0	0	1314	1464	51	5	1203	5	BARD1	2	215645436	Missense_Mutation	SNP	T	TCGA-CV-7437-01A-21D-2129-08	36181942	215645436	27553937	26	48624											
PAX3	5077	broad.mit.edu	37	chr2	223161823	223161823	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacgcagggccggatgccGtggtgggccatctccacgat	7	7	15	12	4	1	1	0	1	1	0	2	3	1	2	4	4	1	1	4	4	0	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr2:223161823G>T	uc010fwo.2	-	2	561	c.195C>A	c.(193-195)CAC>CAA	p.H65Q	PAX3_uc002vmt.1_Missense_Mutation_p.H65Q|PAX3_uc002vmy.1_Missense_Mutation_p.H65Q|PAX3_uc002vmv.1_Missense_Mutation_p.H65Q|PAX3_uc002vmw.1_Missense_Mutation_p.H65Q|PAX3_uc002vmx.1_Missense_Mutation_p.H65Q|PAX3_uc002vmz.1_Missense_Mutation_p.H65Q|PAX3_uc002vna.1_Missense_Mutation_p.H65Q|CCDC140_uc002vnb.1_5'Flank	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	65	Paired.		Missing (in WS1).		apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCGGATGCCGTGGTGGGCCA	0.657			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						15	7					4.7546e-09	5.07158e-09	1	0	T	223161823	T	T	223161823	3	4	268	1	0	0	0	0	1	0	0	0	11534	1136	40	3	1487	3	PAX3	2	223161823	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	7516387	223161823	20037550	27	48625											
TTC21A	199223	broad.mit.edu	37	chr3	39170771	39170771	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catctacctgcagaccctcaGagacaggcgcctctacatca	11	7	7	16	1	4	2	2	0	2	2	4	3	4	2	3	1	3	1	3	1	2	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr3:39170771G>A	uc003cjc.2	+	15	2303	c.2126G>A	c.(2125-2127)AGA>AAA	p.R709K	TTC21A_uc003cje.2_Missense_Mutation_p.R710K|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.R661K	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	709							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CAGACCCTCAGAGACAGGCGC	0.522													67	52					0	0	0	0	A	39170771	A	A	39170771	3	1	268	1	0	0	0	0	1	0	0	0	16755	942	33	2	2187	2	TTC21A	3	39170771	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		39170771	158851659	28	48626											
MAGI1	9223	broad.mit.edu	37	chr3	65376930	65376930	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctctgcaggtgggaactcgGggagcacctgtgtgctgtgg	5	9	17	10	1	1	0	0	0	1	0	2	2	1	2	2	5	4	3	2	5	1	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr3:65376930G>A	uc003dmn.2	-	14	2829	c.2303C>T	c.(2302-2304)CCC>CTC	p.P768L	MAGI1_uc003dmm.2_Missense_Mutation_p.P768L|MAGI1_uc003dmo.2_Missense_Mutation_p.P768L|MAGI1_uc003dmp.2_Missense_Mutation_p.P768L|MAGI1_uc010hnx.1_Missense_Mutation_p.P51L	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	768					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TGGGAACTCGGGGAGCACCTG	0.547													54	25					0	0	0	0	A	65376930	A	A	65376930	3	1	268	1	0	0	0	0	1	0	0	0	9243	1232	43	4	2359	4	MAGI1	3	65376930	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	26206159	65376930	132645500	29	48627											
ZDHHC23	254887	broad.mit.edu	37	chr3	113672830	113672830	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagccttggactgttctctCtgggctacatgtactatgtg	6	15	11	9	0	2	1	0	1	2	0	3	2	2	2	1	2	3	3	1	2	3	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr3:113672830C>T	uc003eau.2	+	3	744	c.445C>T	c.(445-447)CTG>TTG	p.L149L	ZDHHC23_uc003eav.2_Silent_p.L143L	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	149	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						ACTGTTCTCTCTGGGCTACAT	0.522													34	96					0	0	0	0	T	113672830	T	T	113672830	2	4	268	1	0	0	0	0	0	0	0	1	17681	912	32	2		2	ZDHHC23	3	113672830	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	48295900	113672830	84349600	30	48628											
SHOX2	6474	broad.mit.edu	37	chr3	157820514	157820514	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgctggctcagttcctctcGcatgaaggcgtcgggatagt	6	11	13	11	4	2	1	1	1	1	0	6	2	3	2	1	3	0	4	1	3	2	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr3:157820514G>A	uc003fbr.2	-	2	647	c.508C>T	c.(508-510)CGA>TGA	p.R170*	SHOX2_uc003fbs.2_Nonsense_Mutation_p.R194*|SHOX2_uc010hvw.2_Nonsense_Mutation_p.R170*	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	170	Homeobox.				nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			AGTTCCTCTCGCATGAAGGCG	0.597													23	246					0	0	0	0	A	157820514	A	A	157820514	4	1	268	1	0	0	0	0	0	1	0	0	14354	1095	38	1	503	1	SHOX2	3	157820514	Nonsense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	44147684	157820514	40201916	31	48629											
SCHIP1	29970	broad.mit.edu	37	chr3	159605682	159605682	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaacaggaaaaagtctccCgtcgctgatcttgtaagcag	13	8	10	10	2	2	2	0	1	2	1	4	3	2	3	1	1	2	3	1	1	4	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr3:159605682C>T	uc003fcs.1	+	5	1248	c.1182C>T	c.(1180-1182)CCC>CCT	p.P394P	SCHIP1_uc003fcq.1_Silent_p.P470P|SCHIP1_uc003fcr.1_Silent_p.P383P|SCHIP1_uc003fct.1_Silent_p.P381P|SCHIP1_uc010hvz.1_Silent_p.P354P|SCHIP1_uc003fcu.1_Silent_p.P151P|SCHIP1_uc003fcv.1_Silent_p.P167P	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	394						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			AAAAGTCTCCCGTCGCTGATC	0.458													21	97					0	0	0	0	T	159605682	T	T	159605682	2	4	268	1	0	0	0	0	0	0	0	1	13969	639	23	1		1	SCHIP1	3	159605682	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	1785168	159605682	38416748	32	48630											
LRRIQ4	344657	broad.mit.edu	37	chr3	169540507	169540507	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acggaaatcgggctgagcggGaaccgcctggagaaggtgcc	10	4	17	10	4	0	2	0	1	0	1	1	5	0	4	3	5	3	1	3	5	3	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr3:169540507G>A	uc003fgb.2	+	1	798	c.798G>A	c.(796-798)GGG>GGA	p.G266G		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	266	LRR 11.										0						GGCTGAGCGGGAACCGCCTGG	0.612													7	114					0	0	0	0	A	169540507	A	A	169540507	2	1	268	1	0	0	0	0	0	0	0	1	9081	1161	41	2		2	LRRIQ4	3	169540507	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	9934825	169540507	28481923	33	48631											
PHC3	80012	broad.mit.edu	37	chr3	169840414	169840414	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaagtcaaatcttctcctCtccccactgttatagctgct	9	13	5	14	0	4	1	1	0	3	1	6	1	4	1	3	0	2	3	3	0	4	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr3:169840414C>G	uc010hws.1	-	9	1935	c.1871G>C	c.(1870-1872)AGA>ACA	p.R624T	PHC3_uc003fgl.2_Missense_Mutation_p.R636T|PHC3_uc011bpq.1_Missense_Mutation_p.R583T	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	polyhomeotic like 3	624	Pro-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			ATCTTCTCCTCTCCCCACTGT	0.398													10	202					0	0	0	0	G	169840414	G	G	169840414	3	3	268	1	0	0	0	0	1	0	0	0	11873	913	32	2	1108	2	PHC3	3	169840414	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	299907	169840414	28182016	34	48632											
N4BP2	55728	broad.mit.edu	37	chr4	40122594	40122594	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttctgaaatgctgctcagtGaaatgacctgtgagagtcag	11	11	12	7	0	3	4	2	4	1	1	3	5	3	4	1	0	2	3	1	0	2	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr4:40122594G>A	uc003guy.3	+	9	3201	c.2863G>A	c.(2863-2865)GAA>AAA	p.E955K	N4BP2_uc010ifq.2_Missense_Mutation_p.E875K|N4BP2_uc010ifr.2_Missense_Mutation_p.E875K	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	955						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GCTGCTCAGTGAAATGACCTG	0.438													28	36					0	0	0	0	A	40122594	A	A	40122594	3	1	268	1	0	0	0	0	1	0	0	0	10163	1291	45	2	2889	2	N4BP2	4	40122594	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		40122594	151031682	35	48633											
ADAMTS3	9508	broad.mit.edu	37	chr4	73149358	73149358	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acttgttataacctggtatgGagcagtatcgtgccaacact	11	12	9	9	1	0	0	0	0	0	0	1	1	0	1	2	2	4	4	2	2	5	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr4:73149358G>A	uc003hgk.1	-	22	3150	c.3113C>T	c.(3112-3114)TCC>TTC	p.S1038F		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1038	PLAC.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ACCTGGTATGGAGCAGTATCG	0.418													7	116					0	0	0	0	A	73149358	A	A	73149358	3	1	268	1	0	0	0	0	1	0	0	0	267	1174	41	2	508	2	ADAMTS3	4	73149358	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	33026764	73149358	118004918	36	48634											
IL2	3558	broad.mit.edu	37	chr4	123377563	123377563	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacaagtgcaagacttagTgcaatgcaagacaggagttg	14	8	13	6	0	0	3	0	1	0	2	0	4	0	4	0	1	3	4	0	1	5	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr4:123377563T>C	uc003ier.2	-	1	88	c.33A>G	c.(31-33)GCA>GCG	p.A11A		NM_000586	NP_000577	P60568	IL2_HUMAN	interleukin 2 precursor	11					anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity			skin(1)	1				LUSC - Lung squamous cell carcinoma(721;0.185)		CAAGACTTAGTGCAATGCAAG	0.413			T	TNFRSF17	intestinal T-cell lymphoma								39	22					0	0	0	0	C	123377563	C	C	123377563	2	2	268	1	0	0	0	0	0	0	0	1	7705	1683	59	5		5	IL2	4	123377563	Silent	SNP	T	TCGA-CV-7437-01A-21D-2129-08	50228205	123377563	67776713	37	48635											
F11	2160	broad.mit.edu	37	chr4	187205256	187205256	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgttgcagagtgtaccacCaaaatcaagcccaggatcgt	12	9	9	11	1	2	1	1	0	1	1	3	2	2	2	3	1	3	3	3	1	4	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr4:187205256C>T	uc003iza.1	+	11	1479	c.1146C>T	c.(1144-1146)ACC>ACT	p.T382T		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	382					blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	AGTGTACCACCAAAATCAAGC	0.502													32	27					0	0	0	0	T	187205256	T	T	187205256	2	4	268	1	0	0	0	0	0	0	0	1	5362	581	21	4		4	F11	4	187205256	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	63827693	187205256	3949020	38	48636											
FAT1	2195	broad.mit.edu	37	chr4	187630671	187630692	+	Frame_Shift_Del	DEL	TTTCCTCCTTTGGTCCTTATTC	-	-																															ctctattaagaatagctgtaTttcctcctttggtccttatt																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	d40bb6dd-d5a2-466e-b9fe-03b553c19814	g.chr4:187630671_187630692delTTTCCTCCTTTGGTCCTTATTC	uc003izf.2	-	2	478_499	c.290_311delGAATAAGGACCAAAGGAGGAAA	c.(289-312)AGAATAAGGACCAAAGGAGGAAATfs	p.R97fs	FAT1_uc010iso.1_Frame_Shift_Del_p.R97fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	97_104	Extracellular (Potential).|Cadherin 1.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AATAGCTGTATTTCCTCCTTTGGTCCTTATTCTTAGAAAGCA	0.405										HNSCC(5;0.00058)			---	---	---								-	187630692	-	-	187630671	7	5	268	1	0	1	0	1	0	0	0	0	5721	1493	52	0	13559	0	FAT1	4	187630671	Frame_Shift_Del	DEL	TTTCCTCCTTTGGTCCTTATTC	TCGA-CV-7437-01A-21D-2129-08	425415	187630671	3523605	39	48637											
NKD2	85409	broad.mit.edu	37	chr5	1033581	1033581	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagcaaaccgcgagggcccGcgaggaccgggcgggcagcg	8	0	19	14	7	0	0	0	0	0	0	0	3	0	1	3	4	3	3	3	4	1	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	d40bb6dd-d5a2-466e-b9fe-03b553c19814	g.chr5:1033581G>A	uc003jbt.1	+	5	302	c.297G>A	c.(295-297)CCG>CCA	p.P99P	NKD2_uc010itf.1_Silent_p.P99P	NM_033120	NP_149111	Q969F2	NKD2_HUMAN	naked cuticle homolog 2	99	Targeting to the basolateral cell membrane.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding				0	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			GCGAGGGCCCGCGAGGACCGG	0.692													4	2					0	0	0	0	A	1033581	A	A	1033581	2	1	268	1	0	0	0	0	0	0	0	1	10496	1074	38	1		1	NKD2	5	1033581	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08		1033581	179881679	40	48638											
SLC6A3	6531	broad.mit.edu	37	chr5	1416215	1416215	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccctgctaggggctcacctGtagcagttgttggtgaactt	6	12	13	10	0	1	1	1	1	0	0	1	1	1	1	2	3	3	6	2	3	3	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:1416215G>T	uc003jck.2	-	7	1150	c.1029C>A	c.(1027-1029)TAC>TAA	p.Y343*		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	343					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	GGGCTCACCTGTAGCAGTTGT	0.587													14	57					1.05317e-09	1.14419e-09	1	0	T	1416215	T	T	1416215	4	4	268	1	0	0	0	0	0	1	0	0	14749	1372	48	4	869	4	SLC6A3	5	1416215	Nonsense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	382634	1416215	179499045	41	48639											
FAM173B	134145	broad.mit.edu	37	chr5	10239377	10239377	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agcccagtaagtaagaacccCcagttgcttttctgcaaact	12	10	7	12	0	1	1	0	0	1	1	1	1	1	1	3	0	5	5	3	0	4	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:10239377C>T	uc003jeo.2	-	2	137	c.108G>A	c.(106-108)TGG>TGA	p.W36*	FAM173B_uc003jep.2_RNA|FAM173B_uc010itr.2_Nonsense_Mutation_p.W36*	NM_199133	NP_954584	Q6P4H8	F173B_HUMAN	hypothetical protein LOC134145	36						integral to membrane				kidney(1)|central_nervous_system(1)	2						GTAAGAACCCCCAGTTGCTTT	0.478													60	109					0	0	0	0	T	10239377	T	T	10239377	4	4	268	1	0	0	0	0	0	1	0	0	5522	624	22	4	609	4	FAM173B	5	10239377	Nonsense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	8823162	10239377	170675883	42	48640											
CTNND2	1501	broad.mit.edu	37	chr5	11364898	11364898	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catagggggcttctgatagaCgcggtcttcatagatgggat	9	11	14	7	2	3	3	1	1	2	2	3	4	3	4	0	4	0	1	0	4	3	5	rs148824970	byFrequency	TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:11364898C>T	uc003jfa.1	-	8	1427	c.1282G>A	c.(1282-1284)GTC>ATC	p.V428I	CTNND2_uc010itt.2_Missense_Mutation_p.V337I|CTNND2_uc011cmy.1_Missense_Mutation_p.V91I|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	428	ARM 1.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TTCTGATAGACGCGGTCTTCA	0.617													15	59					0	0	0	0	T	11364898	T	T	11364898	3	4	268	1	0	0	0	0	1	0	0	0	4037	536	19	1	2455	1	CTNND2	5	11364898	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	1125521	11364898	169550362	43	48641											
DNAH5	1767	broad.mit.edu	37	chr5	13830755	13830755	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccatctggtctgaacaattGaaaaccacgacgtatttccc	12	11	6	12	2	2	2	0	2	2	0	4	3	4	2	3	1	2	1	3	1	5	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:13830755G>A	uc003jfd.2	-	36	6054	c.6012C>T	c.(6010-6012)TTC>TTT	p.F2004F		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2004	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTGAACAATTGAAAACCACGA	0.473									Kartagener_syndrome				19	104					0	0	0	0	A	13830755	A	A	13830755	2	1	268	1	0	0	0	0	0	0	0	1	4626	1281	45	2		2	DNAH5	5	13830755	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	2465857	13830755	167084505	44	48642											
UGT3A2	167127	broad.mit.edu	37	chr5	36049095	36049095	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtcagagttaatgaaccAcaactctgctttcagtagaa	16	10	7	8	0	3	3	2	1	1	2	3	3	3	3	1	0	3	3	1	0	6	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:36049095A>G	uc003jjz.1	-	4	832	c.739T>C	c.(739-741)TGG>CGG	p.W247R	UGT3A2_uc011cos.1_Missense_Mutation_p.W213R|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	247	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTAATGAACCACAACTCTGCT	0.428													66	77					0	0	0	0	G	36049095	G	G	36049095	3	3	268	1	0	0	0	0	1	0	0	0	17032	159	6	5	848	5	UGT3A2	5	36049095	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08	22218340	36049095	144866165	45	48643											
LMBRD2	92255	broad.mit.edu	37	chr5	36111350	36111350	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accgagcagattcaaacaacGggttcccaaactaataaaag	18	6	7	10	2	1	1	1	0	0	1	2	2	2	1	2	1	4	2	2	1	6	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:36111350G>A	uc003jkb.1	-	14	2066	c.1651C>T	c.(1651-1653)CGT>TGT	p.R551C		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	551	Cytoplasmic (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTCAAACAACGGGTTCCCAAA	0.313													16	36					0	0	0	0	A	36111350	A	A	36111350	3	1	268	1	0	0	0	0	1	0	0	0	8885	1116	39	1	456	1	LMBRD2	5	36111350	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	62255	36111350	144803910	46	48644											
PCDHA2	56146	broad.mit.edu	37	chr5	140176624	140176624	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgccgcgggctcagaggctaCgctggtggatgtcaacgtgt	6	8	16	11	5	2	1	2	0	0	1	2	2	2	2	1	4	2	3	1	4	2	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:140176624C>T	uc003lhd.2	+	1	2181	c.2075C>T	c.(2074-2076)ACG>ATG	p.T692M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.T692M|PCDHA2_uc011czy.1_Missense_Mutation_p.T692M	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	692	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGAGGCTACGCTGGTGGAT	0.647													41	97					0	0	0	0	T	140176624	T	T	140176624	3	4	268	1	0	0	0	0	1	0	0	0	11578	536	19	1	2077	1	PCDHA2	5	140176624	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	104065274	140176624	40738636	47	48645											
PCDHA7	56141	broad.mit.edu	37	chr5	140215817	140215817	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttgcaaccggtggcggccGgtgcgagcatcccgttccgc	5	7	15	14	6	0	0	0	0	0	0	2	1	2	0	4	4	4	4	4	4	1	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:140215817G>A	uc003lhq.2	+	1	1849	c.1849G>A	c.(1849-1851)GGT>AGT	p.G617S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.G617S	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	617	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGCGGCCGGTGCGAGCAT	0.642													28	41					0	0	0	0	A	140215817	A	A	140215817	3	1	268	1	0	0	0	0	1	0	0	0	11583	1116	39	1	1851	1	PCDHA7	5	140215817	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	39193	140215817	40699443	48	48646											
PCDHB1	29930	broad.mit.edu	37	chr5	140431883	140431883	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgagggcaccaacaaagcGataacttactctttagctca	14	8	8	11	2	2	0	1	0	1	0	2	3	2	0	1	1	5	2	1	1	5	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:140431883G>T	uc003lik.1	+	1	905	c.828G>T	c.(826-828)GCG>GCT	p.A276A		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	276	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCAACAAAGCGATAACTTACT	0.507													7	31					0.00198382	0.00202995	1	0	T	140431883	T	T	140431883	2	4	268	1	0	0	0	0	0	0	0	1	11588	1045	37	3		3	PCDHB1	5	140431883	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	216066	140431883	40483377	49	48647											
PCDHB7	56129	broad.mit.edu	37	chr5	140554402	140554402	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccacgctgcacgtgctcctGgtggacggcttctcccagcc	4	8	12	17	3	1	0	0	0	1	0	3	1	2	1	4	3	3	4	4	3	0	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:140554402G>T	uc003lit.2	+	1	2160	c.1986G>T	c.(1984-1986)CTG>CTT	p.L662L		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	662	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGTGCTCCTGGTGGACGGCT	0.701													15	54					1.33834e-09	1.44508e-09	1	0	T	140554402	T	T	140554402	2	4	268	1	0	0	0	0	0	0	0	1	11601	1335	47	4		4	PCDHB7	5	140554402	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	122519	140554402	40360858	50	48648											
PCDHB12	56124	broad.mit.edu	37	chr5	140590512	140590512	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctctcccggaggcggcccCggcccaggcccaggccgact	4	3	14	20	4	1	0	0	0	1	0	2	2	1	1	7	6	0	0	7	6	0	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:140590512C>T	uc003liz.2	+	1	2222	c.2033C>T	c.(2032-2034)CCG>CTG	p.P678L	PCDHB12_uc011dak.1_Missense_Mutation_p.P341L|PCDHB13_uc003lja.1_5'Flank	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	678	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGCGGCCCCGGCCCAGGCC	0.692													11	148					0	0	0	0	T	140590512	T	T	140590512	3	4	268	1	0	0	0	0	1	0	0	0	11591	652	23	1	2035	1	PCDHB12	5	140590512	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	36110	140590512	40324748	51	48649											
C5orf40	408263	broad.mit.edu	37	chr5	156770492	156770492	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcagggctccgaggacGaccaggagatgatggctcct	9	5	15	12	2	0	2	0	1	0	1	2	6	2	3	4	5	0	3	4	5	0	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:156770492G>T	uc003lwu.2	-	2	241	c.53C>A	c.(52-54)TCG>TAG	p.S18*	CYFIP2_uc003lwq.2_Intron|CYFIP2_uc011ddn.1_Intron|CYFIP2_uc011ddo.1_Intron|CYFIP2_uc003lwr.2_Intron|CYFIP2_uc003lws.2_Intron|CYFIP2_uc003lwt.2_Intron|CYFIP2_uc011ddp.1_Intron	NM_001001343	NP_001001343	Q8TBE3	FNDC9_HUMAN	hypothetical protein LOC408263	18	Fibronectin type-III.					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTCCGAGGACGACCAGGAGAT	0.498													16	42					3.57192e-18	4.0822e-18	1	0	T	156770492	T	T	156770492	4	4	268	1	0	0	0	0	0	1	0	0	2309	1059	37	3	625	3	C5orf40	5	156770492	Nonsense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	16179980	156770492	24144768	52	48650											
SH3PXD2B	285590	broad.mit.edu	37	chr5	171849445	171849445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtcaaaaaacttgctgtagCgccggtaaatggcctcggtg	10	9	13	9	3	1	0	1	0	0	0	2	0	1	0	2	4	3	3	2	4	6	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr5:171849445C>T	uc003mbr.2	-	2	302	c.131G>A	c.(130-132)CGC>CAC	p.R44H	SH3PXD2B_uc003mbs.1_Missense_Mutation_p.R44H	NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	44	PX.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTTGCTGTAGCGCCGGTAAAT	0.517													6	11					0	0	0	0	T	171849445	T	T	171849445	3	4	268	1	0	0	0	0	1	0	0	0	14322	768	27	1	2652	1	SH3PXD2B	5	171849445	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	15078953	171849445	9065815	53	48651											
IRF4	3662	broad.mit.edu	37	chr6	407576	407576	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattaccacagatctatccGccattcctctattcaagaat	13	12	4	12	1	3	3	1	0	2	3	5	3	5	3	4	0	1	0	4	0	5	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr6:407576G>A	uc003msz.3	+	9	1447	c.1334G>A	c.(1333-1335)CGC>CAC	p.R445H	IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.R444H	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	445					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		AGATCTATCCGCCATTCCTCT	0.279			T	IGH@	MM 								21	49					0	0	0	0	A	407576	A	A	407576	3	1	268	1	0	0	0	0	1	0	0	0	7871	1087	38	1	1364	1	IRF4	6	407576	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		407576	170707491	54	48652											
F13A1	2162	broad.mit.edu	37	chr6	6266932	6266932	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaagactggatggacagccGcacagacctgtcctctctca	10	7	11	13	1	2	2	1	0	1	2	4	5	3	5	3	3	1	1	3	3	1	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr6:6266932G>T	uc003mwv.2	-	4	553	c.430C>A	c.(430-432)CGG>AGG	p.R144R	F13A1_uc011dib.1_Silent_p.R81R	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	144					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	ATGGACAGCCGCACAGACCTG	0.512													20	43					3.99206e-14	4.39126e-14	1	0	T	6266932	T	T	6266932	2	4	268	1	0	0	0	0	0	0	0	1	5365	1086	38	3		3	F13A1	6	6266932	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	5859356	6266932	164848135	55	48653											
DNAH8	1769	broad.mit.edu	37	chr6	38951989	38951989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttttaataaagggtgtatCatggaatacggttcggtaca	13	13	10	5	2	1	0	1	0	0	0	2	1	1	1	0	4	2	3	0	4	7	7			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr6:38951989C>T	uc003ooe.1	+	85	12908	c.12308C>T	c.(12307-12309)TCA>TTA	p.S4103L	DNAH8_uc003oog.1_Missense_Mutation_p.S552L	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAGGGTGTATCATGGAATACG	0.373													11	45					0	0	0	0	T	38951989	T	T	38951989	3	4	268	1	0	0	0	0	1	0	0	0	4629	838	29	2	12638	2	DNAH8	6	38951989	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	32685057	38951989	132163078	56	48654											
PAPOLB	56903	broad.mit.edu	37	chr7	4901062	4901062	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaggtgaaaaagtcgcttCgatccacatgacttggtgca	12	10	11	8	2	0	3	0	3	0	0	3	4	1	3	1	2	1	2	1	2	2	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:4901062C>T	uc003snk.2	-	1	564	c.380G>A	c.(379-381)CGA>CAA	p.R127Q	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	126					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		AAAGTCGCTTCGATCCACATG	0.438													13	36					0	0	0	0	T	4901062	T	T	4901062	3	4	268	1	0	0	0	0	1	0	0	0	11484	884	31	1	1537	1	PAPOLB	7	4901062	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08		4901062	154237601	57	48655											
NXPH1	30010	broad.mit.edu	37	chr7	8790658	8790658	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcacatgtgccaatttaacGaacggtggaaagtcagaact	14	9	10	8	2	2	1	2	0	0	1	2	3	2	2	1	2	4	0	1	2	5	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:8790658G>A	uc003srv.2	+	3	986	c.75G>A	c.(73-75)ACG>ACA	p.T25T	NXPH1_uc011jxh.1_5'UTR	NM_152745	NP_689958	P58417	NXPH1_HUMAN	neurexophilin 1 precursor	25	II.					extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		CCAATTTAACGAACGGTGGAA	0.423													69	71					0	0	0	0	A	8790658	A	A	8790658	2	1	268	1	0	0	0	0	0	0	0	1	10844	1045	37	1		1	NXPH1	7	8790658	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	3889596	8790658	150348005	58	48656											
DNAH11	8701	broad.mit.edu	37	chr7	21730399	21730399	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtagatttgtatttcttgggGaagctatcacactgaagcca	11	13	10	7	0	2	2	1	1	1	1	2	3	2	3	1	2	2	3	1	2	5	6			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:21730399G>A	uc003svc.2	+	36	5993	c.5962G>A	c.(5962-5964)GAA>AAA	p.E1988K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1988	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ATTTCTTGGGGAAGCTATCAC	0.363									Kartagener_syndrome				48	194					0	0	0	0	A	21730399	A	A	21730399	3	1	268	1	0	0	0	0	1	0	0	0	4621	1175	41	2	6101	2	DNAH11	7	21730399	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	12939741	21730399	137408264	59	48657											
TRA2A	29896	broad.mit.edu	37	chr7	23561437	23561437	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcaggagttcccgttggaGattttgactgagagcgagac	10	9	15	7	2	0	4	0	2	0	3	1	9	1	5	1	2	2	3	1	2	0	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:23561437G>T	uc003swi.2	-	2	273	c.59C>A	c.(58-60)TCT>TAT	p.S20Y	TRA2A_uc011jzb.1_RNA|TRA2A_uc011jzc.1_5'UTR|TRA2A_uc011jzd.1_5'UTR|TRA2A_uc010kuo.1_RNA	NM_013293	NP_037425	Q13595	TRA2A_HUMAN	transformer-2 alpha	20					nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TCCCGTTGGAGATTTTGACTG	0.433													17	89					5.3912e-06	5.64793e-06	1	0	T	23561437	T	T	23561437	3	4	268	1	0	0	0	0	1	0	0	0	16500	942	33	2	817	2	TRA2A	7	23561437	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	1831038	23561437	135577226	60	48658											
ZNF713	349075	broad.mit.edu	37	chr7	56007358	56007358	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcagcattcatcctttactCaacatctgaggattcatact	11	14	5	11	0	5	1	4	1	1	0	6	2	6	2	1	1	4	1	1	1	3	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:56007358C>T	uc003trc.1	+	4	990	c.952C>T	c.(952-954)CAA>TAA	p.Q318*	ZNF713_uc003tra.1_Nonsense_Mutation_p.Q331*|MRPS17_uc003trb.2_Intron	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	318	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ATCCTTTACTCAACATCTGAG	0.398													39	147					0	0	0	0	T	56007358	T	T	56007358	4	4	268	1	0	0	0	0	0	1	0	0	18184	827	29	2	966	2	ZNF713	7	56007358	Nonsense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	32445921	56007358	103131305	61	48659											
CCT6A	908	broad.mit.edu	37	chr7	56120139	56120139	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttctggcgctggagacatCaaacttactaaagacggcaa	13	9	10	9	2	2	2	1	0	1	2	2	3	2	2	0	3	2	3	0	3	5	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:56120139C>T	uc003trl.1	+	2	326	c.162C>T	c.(160-162)ATC>ATT	p.I54I	PSPH_uc003trh.2_5'Flank|PSPH_uc003tri.2_5'Flank|PSPH_uc003trj.2_Intron|PSPH_uc003trk.1_5'Flank|CCT6A_uc003trm.1_Silent_p.I54I|CCT6A_uc011kcu.1_Silent_p.I23I	NM_001762	NP_001753	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A isoform	54					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			upper_aerodigestive_tract(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTGGAGACATCAAACTTACTA	0.423													48	88					0	0	0	0	T	56120139	T	T	56120139	2	4	268	1	0	0	0	0	0	0	0	1	2972	816	29	2		2	CCT6A	7	56120139	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	112781	56120139	103018524	62	48660											
ZNF735	730291	broad.mit.edu	37	chr7	63679804	63679804	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggacatgagaatttacaattAaaaaaatgttgtaaaagagt	20	11	8	2	0	0	2	0	1	0	2	0	4	0	3	0	1	1	2	0	1	9	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:63679804A>T	uc011kdn.1	+	4	375	c.375A>T	c.(373-375)TTA>TTT	p.L125F		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTACAATTAAAAAAATGTT	0.333													29	44					0	0	0	0	T	63679804	T	T	63679804	3	4	268	1	0	0	0	0	1	0	0	0	18191	359	13	5	389	5	ZNF735	7	63679804	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08	7559665	63679804	95458859	63	48661											
ELN	2006	broad.mit.edu	37	chr7	73477973	73477973	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctagtgggagccgctgggctCggaggactcggagtcggagg	6	6	20	9	4	0	0	0	0	0	0	3	5	0	5	1	7	1	2	1	7	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:73477973C>T	uc003tzw.2	+	29	2050	c.1959C>T	c.(1957-1959)CTC>CTT	p.L653L	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Silent_p.L647L|ELN_uc003tzz.2_Silent_p.L566L|ELN_uc003tzo.2_Silent_p.L599L|ELN_uc003tzp.2_Silent_p.L558L|ELN_uc003tzq.2_Silent_p.L511L|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_Silent_p.L628L|ELN_uc003tzt.2_Silent_p.L652L|ELN_uc003tzu.2_Silent_p.L633L|ELN_uc003tzv.2_Silent_p.L618L|ELN_uc003tzx.2_Silent_p.L637L|ELN_uc011kff.1_Silent_p.L647L|ELN_uc003tzy.2_Silent_p.L623L	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	709	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CCGCTGGGCTCGGAGGACTCG	0.597			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						58	86					0	0	0	0	T	73477973	T	T	73477973	2	4	268	1	0	0	0	0	0	0	0	1	5095	871	31	1		1	ELN	7	73477973	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	9798169	73477973	85660690	64	48662											
CACNA2D1	781	broad.mit.edu	37	chr7	81620503	81620503	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaaatacagttaattacctGtaatctgtgccattgacagg	14	13	7	7	0	1	1	0	1	1	0	1	1	1	1	2	1	3	2	2	1	6	6			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:81620503G>C	uc003uhr.1	-	21	2050	c.1794C>G	c.(1792-1794)TAC>TAG	p.Y598*		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	617	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TTAATTACCTGTAATCTGTGC	0.308													17	32					0	0	0	0	C	81620503	C	C	81620503	4	2	268	1	0	0	0	0	0	1	0	0	2560	1372	48	4	1557	4	CACNA2D1	7	81620503	Nonsense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	8142530	81620503	77518160	65	48663											
DNAJB9	4189	broad.mit.edu	37	chr7	108213555	108213555	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaaatcatttccagacaCgccaggatggtggttccagt	11	11	10	9	1	1	2	1	1	0	1	3	3	3	3	3	3	0	1	3	3	2	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:108213555C>T	uc003vfn.2	+	3	632	c.430C>T	c.(430-432)CGC>TGC	p.R144C		NM_012328	NP_036460	Q9UBS3	DNJB9_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 9	144					ER-associated protein catabolic process|protein folding	endoplasmic reticulum|nucleolus	heat shock protein binding|misfolded protein binding|unfolded protein binding				0						TTTCCAGACACGCCAGGATGG	0.348													21	62					0	0	0	0	T	108213555	T	T	108213555	3	4	268	1	0	0	0	0	1	0	0	0	4649	536	19	1	436	1	DNAJB9	7	108213555	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	26593052	108213555	50925108	66	48664											
FEZF1	389549	broad.mit.edu	37	chr7	121943848	121943848	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	acaggtctttgaaagctactCcagaagggtatttctccacc	11	11	8	11	0	2	2	0	1	2	1	4	2	3	2	3	2	2	2	3	2	4	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:121943848C>G	uc003vkd.2	-	1	718	c.644G>C	c.(643-645)GGA>GCA	p.G215A	FEZF1_uc003vkc.2_Missense_Mutation_p.G165A|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	215					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						GAAAGCTACTCCAGAAGGGTA	0.507													23	55					0	0	0	0	G	121943848	G	G	121943848	3	3	268	1	0	0	0	0	1	0	0	0	5857	855	30	2	799	2	FEZF1	7	121943848	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	13730293	121943848	37194815	67	48665											
SPAM1	6677	broad.mit.edu	37	chr7	123593871	123593871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggaagcccccgaataaacGccaccgggcaaggtgttaca	13	5	11	12	3	0	0	0	0	0	0	0	2	0	1	4	3	3	2	4	3	7	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:123593871G>A	uc003vld.2	+	4	649	c.247G>A	c.(247-249)GCC>ACC	p.A83T	SPAM1_uc003vle.2_Missense_Mutation_p.A83T|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.A83T|SPAM1_uc010lku.2_Missense_Mutation_p.A83T	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	83					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	CCGAATAAACGCCACCGGGCA	0.443													26	33					0	0	0	0	A	123593871	A	A	123593871	3	1	268	1	0	0	0	0	1	0	0	0	15052	1087	38	1	249	1	SPAM1	7	123593871	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	1650023	123593871	35544792	68	48666											
ZNF800	168850	broad.mit.edu	37	chr7	127014179	127014179	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caactttaacttttatttctGaactgttggcagtattatta	11	19	5	6	0	1	1	0	1	1	0	1	1	1	1	0	1	3	3	0	1	7	9			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:127014179G>C	uc003vlx.1	-	5	1474	c.1211C>G	c.(1210-1212)TCA>TGA	p.S404*	ZNF800_uc003vlw.1_Nonsense_Mutation_p.S307*|ZNF800_uc003vly.1_Nonsense_Mutation_p.S404*|ZNF800_uc010lla.2_Nonsense_Mutation_p.S404*	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTTTATTTCTGAACTGTTGGC	0.348													30	64					0	0	0	0	C	127014179	C	C	127014179	4	2	268	1	0	0	0	0	0	1	0	0	18236	1294	45	2	791	2	ZNF800	7	127014179	Nonsense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	3420308	127014179	32124484	69	48667											
WEE2	494551	broad.mit.edu	37	chr7	141418927	141418927	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgaaaaagaattcttggAggttgaaaaaattggggttg	15	12	12	2	0	1	3	0	2	1	1	1	4	1	4	0	4	0	2	0	4	7	6			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:141418927A>T	uc003vwn.2	+	4	1047	c.641A>T	c.(640-642)GAG>GTG	p.E214V	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	214	Protein kinase.				egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					GAATTCTTGGAGGTTGAAAAA	0.353													60	52					0	0	0	0	T	141418927	T	T	141418927	3	4	268	1	0	0	0	0	1	0	0	0	17413	304	11	5	655	5	WEE2	7	141418927	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08	14404748	141418927	17719736	70	48668											
MGAM	8972	broad.mit.edu	37	chr7	141721402	141721402	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagttgactgaccaaaccaAtaacaggtttgaagtgcccc	14	8	8	11	0	0	3	0	3	0	0	0	3	0	3	4	1	3	2	4	1	4	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:141721402A>C	uc003vwy.2	+	6	629	c.575A>C	c.(574-576)AAT>ACT	p.N192T		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	192	Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GACCAAACCAATAACAGGTTT	0.433													10	33					0	0	0	0	C	141721402	C	C	141721402	3	2	268	1	0	0	0	0	1	0	0	0	9594	101	4	5	593	5	MGAM	7	141721402	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08	302475	141721402	17417261	71	48669											
GIMAP8	155038	broad.mit.edu	37	chr7	150174742	150174742	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaacaaaggtcaatgatctGagaaaagaaagtgggtggtc	16	9	12	4	0	2	3	1	2	1	2	3	4	2	3	0	3	1	0	0	3	6	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr7:150174742G>T	uc003whj.2	+	5	2202	c.1872G>T	c.(1870-1872)CTG>CTT	p.L624L		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	624	Potential.					endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TCAATGATCTGAGAAAAGAAA	0.443													25	103					2.44723e-14	2.70888e-14	1	0	T	150174742	T	T	150174742	2	4	268	1	0	0	0	0	0	0	0	1	6422	1277	45	2		2	GIMAP8	7	150174742	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	8453340	150174742	8963921	72	48670											
TNKS	8658	broad.mit.edu	37	chr8	9588487	9588487	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcagcaggctacaaccgcGtgtctgttgtagagtacctg	8	10	12	11	3	1	1	0	0	1	1	2	1	1	1	2	1	4	6	2	1	4	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr8:9588487G>A	uc003wss.2	+	14	2094	c.2089G>A	c.(2089-2091)GTG>ATG	p.V697M	TNKS_uc011kww.1_Missense_Mutation_p.V460M|TNKS_uc010lrs.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	697	ANK 10.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		CTACAACCGCGTGTCTGTTGT	0.502													33	6					0	0	0	0	A	9588487	A	A	9588487	3	1	268	1	0	0	0	0	1	0	0	0	16385	1145	40	1	2143	1	TNKS	8	9588487	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		9588487	136775535	73	48671											
FDFT1	2222	broad.mit.edu	37	chr8	11660408	11660408	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggtgcgcttccggatcgggGgcaagcggaaggtgatgccc	6	7	18	10	4	0	1	0	1	0	0	2	3	1	3	2	6	3	2	2	6	2	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr8:11660408G>A	uc003wui.2	+	1	219	c.67G>A	c.(67-69)GGC>AGC	p.G23S	FDFT1_uc003wuh.2_Intron|FDFT1_uc010lsa.1_5'UTR|FDFT1_uc011kxe.1_5'UTR|FDFT1_uc011kxf.1_Missense_Mutation_p.G23S|FDFT1_uc011kxg.1_Missense_Mutation_p.G18E|FDFT1_uc003wuj.2_Missense_Mutation_p.G23S|FDFT1_uc010lsb.2_5'Flank|FDFT1_uc011kxh.1_5'Flank|FDFT1_uc011kxi.1_5'Flank	NM_004462	NP_004453	P37268	FDFT_HUMAN	squalene synthase	23					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity				0	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		CCGGATCGGGGGCAAGCGGAA	0.692													4	15					0	0	0	0	A	11660408	A	A	11660408	3	1	268	1	0	0	0	0	1	0	0	0	5834	1232	43	4	69	4	FDFT1	8	11660408	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	2071921	11660408	134703614	74	48672											
RHOBTB2	23221	broad.mit.edu	37	chr8	22864371	22864371	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtctttgacaacgccatcCgagctgcactcatctcccgc	8	9	7	17	4	3	1	1	1	2	0	5	2	4	1	3	0	3	2	3	0	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr8:22864371C>T	uc003xcq.2	+	5	1150	c.613C>T	c.(613-615)CGA>TGA	p.R205*	RHOBTB2_uc003xcp.2_Nonsense_Mutation_p.R227*|RHOBTB2_uc011kzp.1_Nonsense_Mutation_p.R212*|uc003xcr.2_RNA	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	205	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		CAACGCCATCCGAGCTGCACT	0.632													29	56					0	0	0	0	T	22864371	T	T	22864371	4	4	268	1	0	0	0	0	0	1	0	0	13399	644	23	1	712	1	RHOBTB2	8	22864371	Nonsense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	11203963	22864371	123499651	75	48673											
TNFRSF10A	8797	broad.mit.edu	37	chr8	23082438	23082438	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggcccccgcctcgtggtTcaatcctccccgcggaagag	5	7	11	18	5	1	1	1	0	0	1	5	2	3	2	6	3	0	1	6	3	2	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	d40bb6dd-d5a2-466e-b9fe-03b553c19814	g.chr8:23082438T>C	uc003xda.2	-	1	202	c.137A>G	c.(136-138)GAA>GGA	p.E46G	uc003xdb.1_5'Flank	NM_003844	NP_003835	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily,	46	Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			central_nervous_system(3)|ovary(2)|skin(1)	6		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		GCCTCGTGGTTCAATCCTCCC	0.726													3	1					0	0	0	0	C	23082438	C	C	23082438	3	2	268	1	0	0	0	0	1	0	0	0	16346	1783	62	5	1309	5	TNFRSF10A	8	23082438	Missense_Mutation	SNP	T	TCGA-CV-7437-01A-21D-2129-08	218067	23082438	123281584	76	48674											
LETM2	137994	broad.mit.edu	37	chr8	38264944	38264944	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaccatcaacacctatttCattacctaaaggacccatca	16	9	2	14	0	3	0	3	0	0	0	3	1	3	1	4	1	3	0	4	1	6	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr8:38264944C>A	uc003xlm.1	+	10	1406	c.1235C>A	c.(1234-1236)TCA>TAA	p.S412*	LETM2_uc003xll.1_Nonsense_Mutation_p.S364*|LETM2_uc003xln.1_Nonsense_Mutation_p.S256*|LETM2_uc003xlo.1_Nonsense_Mutation_p.S256*	NM_144652	NP_653253	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane	459	Mitochondrial matrix (Potential).					integral to membrane|mitochondrial inner membrane					0	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			ACACCTATTTCATTACCTAAA	0.378													30	89					3.1745e-13	3.47026e-13	1	0	A	38264944	A	A	38264944	4	1	268	1	0	0	0	0	0	1	0	0	8775	838	29	2	1117	2	LETM2	8	38264944	Nonsense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	15182506	38264944	108099078	77	48675											
PXDNL	137902	broad.mit.edu	37	chr8	52321226	52321226	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcccagtgggggttcagggcGgacagctccgtggccatcct	5	8	15	13	2	1	0	1	0	0	0	4	1	4	1	4	5	1	2	4	5	0	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr8:52321226G>A	uc003xqu.3	-	17	3059	c.2958C>T	c.(2956-2958)TCC>TCT	p.S986S	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	986					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GGTTCAGGGCGGACAGCTCCG	0.642													4	5					0	0	0	0	A	52321226	A	A	52321226	2	1	268	1	0	0	0	0	0	0	0	1	12913	1103	39	1		1	PXDNL	8	52321226	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	14056282	52321226	94042796	78	48676											
TOX	9760	broad.mit.edu	37	chr8	59764139	59764139	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actggatggtgaaggagttgCagacttgcttccaggtggag	9	10	16	6	0	0	2	0	1	0	1	1	5	1	5	1	5	2	3	1	5	1	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr8:59764139C>T	uc003xtw.1	-	4	858	c.637G>A	c.(637-639)GCA>ACA	p.A213T		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	213						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				GAAGGAGTTGCAGACTTGCTT	0.438													15	79					0	0	0	0	T	59764139	T	T	59764139	3	4	268	1	0	0	0	0	1	0	0	0	16444	710	25	4	967	4	TOX	8	59764139	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	7442913	59764139	86599883	79	48677											
KCNB2	9312	broad.mit.edu	37	chr8	73849229	73849229	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggagatgctatacaatgaaAtcaccaagacacagcctcat	16	8	7	10	0	2	3	2	1	0	2	2	4	2	3	2	1	3	1	2	1	5	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr8:73849229A>G	uc003xzb.2	+	3	2227	c.1639A>G	c.(1639-1641)ATC>GTC	p.I547V		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	547	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			ATACAATGAAATCACCAAGAC	0.488													23	88					0	0	0	0	G	73849229	G	G	73849229	3	3	268	1	0	0	0	0	1	0	0	0	8052	101	4	5	1645	5	KCNB2	8	73849229	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08	14085090	73849229	72514793	80	48678											
FAM164A	51101	broad.mit.edu	37	chr8	79588079	79588079	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgcaagatttgtggaagaaCattctttccagtagcattag	12	14	9	6	0	1	2	0	0	1	2	2	3	2	3	1	1	3	3	1	1	5	6			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr8:79588079C>A	uc003ybd.2	+	2	176	c.74C>A	c.(73-75)ACA>AAA	p.T25K		NM_016010	NP_057094	Q96GY0	F164A_HUMAN	hypothetical protein LOC51101	25										ovary(1)	1						TGTGGAAGAACATTCTTTCCA	0.323													35	147					5.44703e-19	6.26586e-19	1	0	A	79588079	A	A	79588079	3	1	268	1	0	0	0	0	1	0	0	0	5506	478	17	4	80	4	FAM164A	8	79588079	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	5738850	79588079	66775943	81	48679											
CNGB3	54714	broad.mit.edu	37	chr8	87660048	87660048	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttaacatcctatttgctCtaaacattggattaaaccca	13	14	3	11	0	1	0	0	0	1	0	2	1	2	1	3	1	4	1	3	1	6	7			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr8:87660048C>G	uc003ydx.2	-	8	1017	c.971G>C	c.(970-972)AGA>ACA	p.R324T	CNGB3_uc010maj.2_Missense_Mutation_p.R186T	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	324	Extracellular (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						CCTATTTGCTCTAAACATTGG	0.294													26	114					0	0	0	0	G	87660048	G	G	87660048	3	3	268	1	0	0	0	0	1	0	0	0	3616	913	32	2	1502	2	CNGB3	8	87660048	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	8071969	87660048	58703974	82	48680											
SLC45A4	57210	broad.mit.edu	37	chr8	142229896	142229896	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgtgagcacgatgccaatggGctgccggttggggacatcgc	7	7	16	11	4	0	1	0	1	0	0	1	3	0	2	2	4	3	3	2	4	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	d40bb6dd-d5a2-466e-b9fe-03b553c19814	g.chr8:142229896G>C	uc003ywd.1	-	3	618	c.310C>G	c.(310-312)CCC>GCC	p.P104A	SLC45A4_uc003ywc.1_Missense_Mutation_p.P104A|SLC45A4_uc010meq.1_Missense_Mutation_p.P102A	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	155	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			ATGCCAATGGGCTGCCGGTTG	0.662													6	5					0	0	0	0	C	142229896	C	C	142229896	3	2	268	1	0	0	0	0	1	0	0	0	14707	1203	42	4	2110	4	SLC45A4	8	142229896	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	54569848	142229896	4134126	83	48681											
IFNK	56832	broad.mit.edu	37	chr9	27524569	27524569	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctgcaatacacccaacctAtgaagagggacatcaagaag	16	7	8	10	0	2	3	1	1	1	2	2	4	2	4	2	1	3	1	2	1	7	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr9:27524569A>G	uc003zqp.2	+	1	258	c.235A>G	c.(235-237)ATG>GTG	p.M79V	MOBKL2B_uc003zqn.2_Intron	NM_020124	NP_064509	Q9P0W0	IFNK_HUMAN	interferon kappa precursor	79					cytokine-mediated signaling pathway|defense response|natural killer cell activation|negative regulation of cell proliferation|positive regulation of innate immune response|regulation of transcription, DNA-dependent|response to virus	extracellular space	cytokine activity|interferon-alpha/beta receptor binding				0		all_neural(11;7.9e-11)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.000158)		CACCCAACCTATGAAGAGGGA	0.423													32	82					0	0	0	0	G	27524569	G	G	27524569	3	3	268	1	0	0	0	0	1	0	0	0	7590	449	16	5	237	5	IFNK	9	27524569	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08		27524569	113688862	84	48682											
ALDH1B1	219	broad.mit.edu	37	chr9	38396909	38396909	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaactcctctgtggcggAgagcgtttcggggagcgtgg	7	8	17	9	4	1	1	0	0	1	1	3	3	2	2	1	5	3	2	1	5	2	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	d40bb6dd-d5a2-466e-b9fe-03b553c19814	g.chr9:38396909A>G	uc004aay.2	+	2	1276	c.1164A>G	c.(1162-1164)GGA>GGG	p.G388G		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	388					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	TCTGTGGCGGAGAGCGTTTCG	0.562													8	52					0	0	0	0	G	38396909	G	G	38396909	2	3	268	1	0	0	0	0	0	0	0	1	493	291	11	5		5	ALDH1B1	9	38396909	Silent	SNP	A	TCGA-CV-7437-01A-21D-2129-08	10872340	38396909	102816522	85	48683											
PIP5K1B	8395	broad.mit.edu	37	chr9	71532547	71532547	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccctcaaagagaaagaggaGgagaccccacaaaatgtgcc	16	4	10	11	0	1	3	1	0	0	3	2	6	2	4	4	2	1	0	4	2	4	0	rs61752951	byFrequency	TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr9:71532547G>A	uc004agu.2	+	9	1160	c.855G>A	c.(853-855)GAG>GAA	p.E285E	PIP5K1B_uc011lrq.1_Silent_p.E285E|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	285	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		AGAAAGAGGAGGAGACCCCAC	0.463													10	215					0	0	0	0	A	71532547	A	A	71532547	2	1	268	1	0	0	0	0	0	0	0	1	11995	991	35	4		4	PIP5K1B	9	71532547	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	33135638	71532547	69680884	86	48684											
TRPM3	80036	broad.mit.edu	37	chr9	73151427	73151427	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttgagggggaaaacataaaGctatgagatttcacaatggg	15	9	12	5	0	1	2	1	2	0	1	1	4	1	3	0	3	2	1	0	3	6	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr9:73151427G>A	uc004aid.2	-	25	4810	c.4566C>T	c.(4564-4566)AGC>AGT	p.S1522S	TRPM3_uc004ahu.2_Silent_p.S1364S|TRPM3_uc004ahv.2_Silent_p.S1324S|TRPM3_uc004ahw.2_Silent_p.S1394S|TRPM3_uc004ahx.2_Silent_p.S1381S|TRPM3_uc004ahy.2_Silent_p.S1384S|TRPM3_uc004ahz.2_Silent_p.S1371S|TRPM3_uc004aia.2_Silent_p.S1369S|TRPM3_uc004aib.2_Silent_p.S1359S|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1547	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AAAACATAAAGCTATGAGATT	0.458													59	30					0	0	0	0	A	73151427	A	A	73151427	2	1	268	1	0	0	0	0	0	0	0	1	16654	962	34	4		4	TRPM3	9	73151427	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	1618880	73151427	68062004	87	48685											
ZNF484	83744	broad.mit.edu	37	chr9	95609196	95609196	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtgaatctgctgatgtaCgtggagctgtgatttcttag	7	16	13	5	1	2	3	0	3	2	0	2	4	2	4	0	1	3	3	0	1	3	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr9:95609196C>T	uc004asu.1	-	5	2022	c.1873G>A	c.(1873-1875)GTA>ATA	p.V625I	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Missense_Mutation_p.V627I|ZNF484_uc010mrb.1_Missense_Mutation_p.V589I|ZNF484_uc004asv.1_Missense_Mutation_p.V589I	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	625	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCTGATGTACGTGGAGCTGT	0.393													25	41					0	0	0	0	T	95609196	T	T	95609196	3	4	268	1	0	0	0	0	1	0	0	0	18004	536	19	1	689	1	ZNF484	9	95609196	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	22457769	95609196	45604235	88	48686											
RAPGEF1	2889	broad.mit.edu	37	chr9	134473675	134473675	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccgactgagccgactccaGagcatctggtgactttgggg	7	9	13	12	2	1	3	0	2	1	1	3	5	3	3	3	3	2	1	3	3	0	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr9:134473675G>C	uc004cbc.2	-	13	2096	c.1966C>G	c.(1966-1968)CTG>GTG	p.L656V	RAPGEF1_uc004cbb.2_Missense_Mutation_p.L674V|RAPGEF1_uc010mzm.2_RNA|RAPGEF1_uc010mzn.2_Missense_Mutation_p.L831V|RAPGEF1_uc004cbd.2_Missense_Mutation_p.L661V|RAPGEF1_uc010mzs.1_Missense_Mutation_p.L188V|RAPGEF1_uc010mzl.1_Missense_Mutation_p.L154V|RAPGEF1_uc010mzo.1_3'UTR|RAPGEF1_uc010mzp.1_Missense_Mutation_p.L133V|RAPGEF1_uc010mzq.1_Missense_Mutation_p.L240V|RAPGEF1_uc010mzr.1_Missense_Mutation_p.L241V	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	656					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GCCGACTCCAGAGCATCTGGT	0.582													10	16					0	0	0	0	C	134473675	C	C	134473675	3	2	268	1	0	0	0	0	1	0	0	0	13108	933	33	2	1315	2	RAPGEF1	9	134473675	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	38864479	134473675	6739756	89	48687											
LARP4B	23185	broad.mit.edu	37	chr10	931622	931622	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctggactctctgcgtctGcggttcagccacaaccttag	6	11	9	15	2	3	0	1	0	2	0	5	1	4	1	3	2	4	1	3	2	2	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr10:931622G>A	uc001ifs.1	-	1	81	c.40C>T	c.(40-42)CAG>TAG	p.Q14*		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	14							nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						CTCTGCGTCTGCGGTTCAGCC	0.512													26	45					0	0	0	0	A	931622	A	A	931622	4	1	268	1	0	0	0	0	0	1	0	0	8671	1328	46	4	2244	4	LARP4B	10	931622	Nonsense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		931622	134603125	90	48688											
SLC39A12	221074	broad.mit.edu	37	chr10	18280093	18280093	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgaaggttcttggtttacAtaagcaggaagccccagaat	12	10	10	9	0	1	2	0	1	1	1	1	3	1	3	3	3	3	3	3	3	5	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr10:18280093A>T	uc001ipo.2	+	8	1556	c.1283A>T	c.(1282-1284)CAT>CTT	p.H428L	SLC39A12_uc001ipn.2_Missense_Mutation_p.H428L|SLC39A12_uc001ipp.2_Missense_Mutation_p.H428L|SLC39A12_uc010qck.1_Missense_Mutation_p.H294L	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	428	Cytoplasmic (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						CTTGGTTTACATAAGCAGGAA	0.373													11	42					0	0	0	0	T	18280093	T	T	18280093	3	4	268	1	0	0	0	0	1	0	0	0	14679	217	8	5	1309	5	SLC39A12	10	18280093	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08	17348471	18280093	117254654	91	48689											
OR13A1	79290	broad.mit.edu	37	chr10	45799805	45799805	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcggttaccaacgtctggttActcatcatccttgggctggg	6	13	11	11	2	3	0	2	0	1	0	5	0	4	0	2	4	3	3	2	4	3	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr10:45799805A>G	uc001jcc.1	-	4	375	c.66T>C	c.(64-66)AGT>AGC	p.S22S	OR13A1_uc001jcd.1_Silent_p.S18S	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACGTCTGGTTACTCATCATCC	0.502													23	60					0	0	0	0	G	45799805	G	G	45799805	2	3	268	1	0	0	0	0	0	0	0	1	10987	388	14	5		5	OR13A1	10	45799805	Silent	SNP	A	TCGA-CV-7437-01A-21D-2129-08	27519712	45799805	89734942	92	48690											
TMEM26	219623	broad.mit.edu	37	chr10	63170317	63170317	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accacgaggaagttcttcgcGgcaaagaacaccagcatctg	13	6	10	12	3	2	1	0	0	2	1	3	3	2	2	2	2	2	3	2	2	3	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr10:63170317G>A	uc001jlo.2	-	6	1239	c.870C>T	c.(868-870)GCC>GCT	p.A290A	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlp.1_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	290	Helical; (Potential).					integral to membrane					0	Prostate(12;0.0112)					AGTTCTTCGCGGCAAAGAACA	0.507													3	46					0	0	0	0	A	63170317	A	A	63170317	2	1	268	1	0	0	0	0	0	0	0	1	16217	1103	39	1		1	TMEM26	10	63170317	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	17370512	63170317	72364430	93	48691											
RTKN2	219790	broad.mit.edu	37	chr10	64022543	64022543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccatattccttctcgcattCgaatttctaagtctattttt	8	20	3	10	2	3	0	0	0	3	0	7	1	5	0	2	0	0	1	2	0	4	9			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr10:64022543C>T	uc001jlw.2	-	2	195	c.98G>A	c.(97-99)CGA>CAA	p.R33Q	ZNF365_uc001jly.3_Intron|RTKN2_uc001jlx.2_Missense_Mutation_p.R33Q	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	33					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					TTCTCGCATTCGAATTTCTAA	0.333													7	26					0	0	0	0	T	64022543	T	T	64022543	3	4	268	1	0	0	0	0	1	0	0	0	13788	884	31	1	1775	1	RTKN2	10	64022543	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	852226	64022543	71512204	94	48692											
CDH23	64072	broad.mit.edu	37	chr10	73545397	73545397	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacatcccagacagggatcGtcactgtgaaccggcccctg	9	6	10	16	2	1	2	1	1	0	1	3	3	2	3	5	2	1	0	5	2	1	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr10:73545397G>A	uc001jrx.3	+	42	6099	c.5722G>A	c.(5722-5724)GTC>ATC	p.V1908I		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1908	Cadherin 18.|Extracellular (Potential).		V -> I.		calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GACAGGGATCGTCACTGTGAA	0.582													3	4					0	0	0	0	A	73545397	A	A	73545397	3	1	268	1	0	0	0	0	1	0	0	0	3123	1145	40	1	6237	1	CDH23	10	73545397	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	9522854	73545397	61989350	95	48693											
C10orf12	26148	broad.mit.edu	37	chr10	98742657	98742657	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaattccctgaggcctctGataggtgcctaagaagtcaa	14	9	9	9	0	2	3	1	2	1	1	3	3	3	3	3	2	1	0	3	2	6	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr10:98742657G>A	uc001kmv.2	+	1	1617	c.1510G>A	c.(1510-1512)GAT>AAT	p.D504N		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	504										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGAGGCCTCTGATAGGTGCCT	0.398													32	62					0	0	0	0	A	98742657	A	A	98742657	3	1	268	1	0	0	0	0	1	0	0	0	1595	1290	45	2	1512	2	C10orf12	10	98742657	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	25197260	98742657	36792090	96	48694											
DHDPSL	112817	broad.mit.edu	37	chr10	99371333	99371333	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtttggctactatggaggcCcctgccgcgcccccttgcag	4	9	13	15	2	0	0	0	0	0	0	0	1	0	1	5	4	3	3	5	4	2	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr10:99371333C>T	uc001kny.2	+	7	1260	c.901C>T	c.(901-903)CCC>TCC	p.P301S	DHDPSL_uc001knz.2_Missense_Mutation_p.P138S|PI4K2A_uc010qoy.1_Intron	NM_138413	NP_612422	Q86XE5	HOGA1_HUMAN	DHDPS-like protein isoform 1	301					glyoxylate catabolic process	mitochondrion	4-hydroxy-2-oxoglutarate aldolase activity				0						CTATGGAGGCCCCTGCCGCGC	0.612													17	31					0	0	0	0	T	99371333	T	T	99371333	3	4	268	1	0	0	0	0	1	0	0	0	4502	623	22	4	927	4	DHDPSL	10	99371333	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	628676	99371333	36163414	97	48695											
CHST15	51363	broad.mit.edu	37	chr10	125771991	125771991	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcatagagcccaacctggagCctcacctaggaccacagaag	13	4	10	14	0	1	2	1	0	0	2	1	4	1	4	5	2	3	1	5	2	4	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr10:125771991C>G	uc001lhl.2	-	6	1866	c.1353G>C	c.(1351-1353)AGG>AGC	p.R451S	CHST15_uc001lhm.2_Missense_Mutation_p.R451S|CHST15_uc001lhn.2_Missense_Mutation_p.R451S	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	451	Lumenal (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						CAACCTGGAGCCTCACCTAGG	0.493													8	18					0	0	0	0	G	125771991	G	G	125771991	3	3	268	1	0	0	0	0	1	0	0	0	3418	738	26	4	340	4	CHST15	10	125771991	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	26400658	125771991	9762756	98	48696											
OR51I1	390063	broad.mit.edu	37	chr11	5462252	5462252	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagaagggcagtcgtttcaCcacaaaagggaaagggaaga	16	4	14	7	1	1	2	1	0	0	2	2	4	1	4	1	3	0	3	1	3	5	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr11:5462252C>T	uc010qze.1	-	1	493	c.493G>A	c.(493-495)GTG>ATG	p.V165M	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGTCGTTTCACCACAAAAGGG	0.458													3	49					0	0	0	0	T	5462252	T	T	5462252	3	4	268	1	0	0	0	0	1	0	0	0	11154	507	18	4	455	4	OR51I1	11	5462252	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08		5462252	129544264	99	48697											
OR52N1	79473	broad.mit.edu	37	chr11	5809550	5809550	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccttgcagtatggaaggcgcTtggtgaggaaagtggaaggg	10	8	18	5	1	0	1	0	1	0	0	0	4	0	4	1	6	1	3	1	6	4	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr11:5809550T>C	uc010qzo.1	-	1	497	c.497A>G	c.(496-498)AAG>AGG	p.K166R	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		TGGAAGGCGCTTGGTGAGGAA	0.488													15	32					0	0	0	0	C	5809550	C	C	5809550	3	2	268	1	0	0	0	0	1	0	0	0	11181	1609	56	5	468	5	OR52N1	11	5809550	Missense_Mutation	SNP	T	TCGA-CV-7437-01A-21D-2129-08	347298	5809550	129196966	100	48698											
DKK3	27122	broad.mit.edu	37	chr11	12030045	12030045	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgggcttgactggagccgAggtcgccgtcggagcgggcg	4	5	20	12	7	0	1	0	1	0	0	2	4	0	3	3	5	2	1	3	5	0	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr11:12030045A>T	uc001mju.2	-	1	142	c.85T>A	c.(85-87)TCG>ACG	p.S29T	DKK3_uc010rcf.1_Missense_Mutation_p.S29T|DKK3_uc001mjv.2_Missense_Mutation_p.S29T|DKK3_uc001mjw.2_Missense_Mutation_p.S29T|DKK3_uc010rcg.1_Missense_Mutation_p.S29T|DKK3_uc001mjx.2_Missense_Mutation_p.S29T	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	29	O-glycosylated at one site.				adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		ACTGGAGCCGAGGTCGCCGTC	0.716													3	13					0	0	0	0	T	12030045	T	T	12030045	3	4	268	1	0	0	0	0	1	0	0	0	4568	304	11	5	995	5	DKK3	11	12030045	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08	6220495	12030045	122976471	101	48699											
COPB1	1315	broad.mit.edu	37	chr11	14504607	14504607	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgttcatgagcaggatgctCttttaattctatcaagcgat	10	15	8	8	2	4	1	2	1	2	0	5	3	4	2	0	1	3	3	0	1	3	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr11:14504607C>G	uc001mli.2	-	8	1235	c.928G>C	c.(928-930)GAG>CAG	p.E310Q	COPB1_uc001mlg.2_Missense_Mutation_p.E310Q|COPB1_uc001mlh.2_Missense_Mutation_p.E310Q	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	310	HEAT 4.				COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						GCAGGATGCTCTTTTAATTCT	0.333													27	5					0	0	0	0	G	14504607	G	G	14504607	3	3	268	1	0	0	0	0	1	0	0	0	3743	922	32	2	1993	2	COPB1	11	14504607	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	2474562	14504607	120501909	102	48700											
EXT2	2132	broad.mit.edu	37	chr11	44146485	44146485	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agagggtgtcctttctgtccGtaagcgctgccacaagcacc	8	9	11	13	2	1	1	0	0	1	1	3	1	3	1	4	1	3	3	4	1	2	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr11:44146485G>A	uc001mxz.2	+	5	1224	c.890G>A	c.(889-891)CGT>CAT	p.R297H	EXT2_uc010rfo.1_Missense_Mutation_p.R325H|EXT2_uc001mxy.2_Missense_Mutation_p.R310H|EXT2_uc009ykt.2_Missense_Mutation_p.R297H|EXT2_uc001mya.2_Missense_Mutation_p.R330H	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	297	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						CTTTCTGTCCGTAAGCGCTGC	0.502			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				19	75					0	0	0	0	A	44146485	A	A	44146485	3	1	268	1	0	0	0	0	1	0	0	0	5349	1145	40	1	1007	1	EXT2	11	44146485	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	29641878	44146485	90860031	103	48701											
NXF1	10482	broad.mit.edu	37	chr11	62571396	62571396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caccatatttccaccggaagGgaccccggcctttcttcttt	7	12	7	15	2	2	0	0	0	2	0	3	2	3	2	6	3	0	0	6	3	2	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr11:62571396G>A	uc001nvf.1	-	2	219	c.83C>T	c.(82-84)CCC>CTC	p.P28L	NXF1_uc001nvg.1_Missense_Mutation_p.P28L|NXF1_uc009yog.1_Missense_Mutation_p.P71L|NXF1_uc010rmh.1_Intron	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	28	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						CCACCGGAAGGGACCCCGGCC	0.473													96	183					0	0	0	0	A	62571396	A	A	62571396	3	1	268	1	0	0	0	0	1	0	0	0	10836	1232	43	4	1911	4	NXF1	11	62571396	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	18424911	62571396	72435120	104	48702											
RASGRP2	10235	broad.mit.edu	37	chr11	64510284	64510284	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accgaaggcttcgatgcaccCgcggagcagctcctccaccg	8	5	11	17	5	0	0	0	0	0	0	3	3	2	1	5	2	3	4	5	2	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr11:64510284C>T	uc009ypu.2	-	2	282	c.55G>A	c.(55-57)GGG>AGG	p.G19R	RASGRP2_uc001oat.2_5'Flank|RASGRP2_uc001oau.2_5'Flank|RASGRP2_uc009ypv.2_Missense_Mutation_p.G19R|RASGRP2_uc009ypw.2_Missense_Mutation_p.G19R|RASGRP2_uc001oaw.1_Silent_p.A321A	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	19	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						TCGATGCACCCGCGGAGCAGC	0.731													3	9					0	0	0	0	T	64510284	T	T	64510284	3	4	268	1	0	0	0	0	1	0	0	0	13140	652	23	1	1834	1	RASGRP2	11	64510284	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	1938888	64510284	70496232	105	48703											
POLA2	23649	broad.mit.edu	37	chr11	65064593	65064608	+	Frame_Shift_Del	DEL	TGTCCTCGGCTGTGTC	-	-																															ctctcctctcctccccaggaTgtcctcggctgtgtctgtgt																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr11:65064593_65064608delTGTCCTCGGCTGTGTC	uc001odj.2	+	18	1992_2007	c.1650_1665delTGTCCTCGGCTGTGTC	c.(1648-1665)GATGTCCTCGGCTGTGTCfs	p.D550fs	POLA2_uc001odk.2_Frame_Shift_Del_p.D247fs	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	550_555					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	CTCCCCAGGATGTCCTCGGCTGTGTCTGTGTGAACC	0.602													---	---	---								-	65064608	-	-	65064593	7	5	268	1	0	1	0	1	0	0	0	0	12243	1461	51	0	1720	0	POLA2	11	65064593	Frame_Shift_Del	DEL	TGTCCTCGGCTGTGTC	TCGA-CV-7437-01A-21D-2129-08	554309	65064593	69941923	106	48704											
RCE1	9986	broad.mit.edu	37	chr11	66612403	66612403	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggaaccaagtgatcgcccCgctgacagaggagctggtgt	9	6	15	11	3	0	3	0	2	0	1	1	5	0	5	3	3	2	2	3	3	2	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr11:66612403C>T	uc001ojk.1	+	5	559	c.515C>T	c.(514-516)CCG>CTG	p.P172L	RCE1_uc001ojl.1_Missense_Mutation_p.P68L	NM_005133	NP_005124	Q9Y256	FACE2_HUMAN	prenyl protein peptidase RCE1 isoform 1	172					proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			ovary(1)|breast(1)	2						GTGATCGCCCCGCTGACAGAG	0.632													21	10					0	0	0	0	T	66612403	T	T	66612403	3	4	268	1	0	0	0	0	1	0	0	0	13241	652	23	1	533	1	RCE1	11	66612403	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	1547810	66612403	68394113	107	48705											
B3GNT6	192134	broad.mit.edu	37	chr11	76750656	76750656	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcctgcctcctggtgggcGtgagtttcttagcactgcag	4	12	14	11	1	1	1	0	1	1	0	2	1	2	1	3	3	3	3	3	3	1	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr11:76750656G>A	uc001oxw.2	+	2	149	c.61G>A	c.(61-63)GTG>ATG	p.V21M		NM_138706	NP_619651	Q6ZMB0	B3GN6_HUMAN	UDP-GlcNAc:betaGal	21	Helical; Signal-anchor for type II membrane protein; (Potential).				O-glycan processing, core 3	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|galactosyltransferase activity				0						CCTGGTGGGCGTGAGTTTCTT	0.657											OREG0021252	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	78	37					0	0	0	0	A	76750656	A	A	76750656	3	1	268	1	0	0	0	0	1	0	0	0	1263	1145	40	1	63	1	B3GNT6	11	76750656	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	10138253	76750656	58255860	108	48706											
C1S	716	broad.mit.edu	37	chr12	7169971	7169971	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagctgtcagagaactgtgcGtatgactcagtgcaggtatg	10	10	14	7	1	2	2	2	1	0	1	2	4	2	2	0	1	4	4	0	1	3	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:7169971G>A	uc001qsj.2	+	6	917	c.198G>A	c.(196-198)GCG>GCA	p.A66A	C1S_uc001qsk.2_Silent_p.A66A|C1S_uc001qsl.2_Silent_p.A66A|C1S_uc009zfr.2_Intron|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	66	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	AGAACTGTGCGTATGACTCAG	0.468													37	151					0	0	0	0	A	7169971	A	A	7169971	2	1	268	1	0	0	0	0	0	0	0	1	1983	1132	40	1		1	C1S	12	7169971	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08		7169971	126681924	109	48707											
CLSTN3	9746	broad.mit.edu	37	chr12	7302138	7302138	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgacagacacacgcatgtcGgatgagattgtgcacaacct	12	8	11	10	2	0	3	0	2	0	2	1	5	0	4	1	1	2	2	1	1	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:7302138G>T	uc001qsr.2	+	14	2372	c.2094G>T	c.(2092-2094)TCG>TCT	p.S698S	CLSTN3_uc001qss.2_Silent_p.S710S	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	698	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						CACGCATGTCGGATGAGATTG	0.577													36	54					9.9191e-30	1.17957e-29	1	0	T	7302138	T	T	7302138	2	4	268	1	0	0	0	0	0	0	0	1	3578	1103	39	3		3	CLSTN3	12	7302138	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	132167	7302138	126549757	110	48708											
MFAP5	8076	broad.mit.edu	37	chr12	8800752	8800752	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagtcggaagtaattggagcGacggagtctcctagggggca	11	7	16	7	3	1	0	0	0	1	0	3	4	1	3	1	5	1	2	1	5	4	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:8800752G>A	uc001qut.1	-	10	670	c.457C>T	c.(457-459)CGC>TGC	p.R153C	MFAP5_uc001qus.2_Missense_Mutation_p.R143C|MFAP5_uc009zge.1_Missense_Mutation_p.R128C	NM_003480	NP_003471	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5 precursor	153						microfibril	extracellular matrix structural constituent			breast(1)	1	Lung SC(5;0.184)					TAATTGGAGCGACGGAGTCTC	0.458													27	56					0	0	0	0	A	8800752	A	A	8800752	3	1	268	1	0	0	0	0	1	0	0	0	9571	1058	37	1	68	1	MFAP5	12	8800752	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	1498614	8800752	125051143	111	48709											
C12orf68	387856	broad.mit.edu	37	chr12	48578417	48578417	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggtctccttgggggggAcgggccacttgtggagcccc	3	9	17	12	1	1	0	0	0	1	0	2	2	1	2	4	6	2	1	4	6	0	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:48578417A>G	uc001rrj.2	+	1	1052	c.512A>G	c.(511-513)GAC>GGC	p.D171G		NM_001013635	NP_001013657	Q52MB2	CL068_HUMAN	hypothetical protein LOC387856	171						cytoplasm				central_nervous_system(1)	1						CTTGGGGGGGACGGGCCACTT	0.587													2	5					0	0	0	0	G	48578417	G	G	48578417	3	3	268	1	0	0	0	0	1	0	0	0	1716	275	10	5	514	5	C12orf68	12	48578417	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08	39777665	48578417	85273478	112	48710											
MLL2	8085	broad.mit.edu	37	chr12	49435964	49435964	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaactcctcatccttctccCagcgctgaagactccgctgg	7	9	7	18	2	2	2	1	1	1	1	6	2	5	2	5	1	2	2	5	1	2	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:49435964C>T	uc001rta.3	-	28	6017	c.6017G>A	c.(6016-6018)TGG>TAG	p.W2006*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2006					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ATCCTTCTCCCAGCGCTGAAG	0.582			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			11	3					0	0	0	0	T	49435964	T	T	49435964	4	4	268	1	0	0	0	0	0	1	0	0	9674	595	21	4	10704	4	MLL2	12	49435964	Nonsense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	857547	49435964	84415931	113	48711											
KCNH3	23416	broad.mit.edu	37	chr12	49950962	49950966	+	Splice_Site	DEL	ACAGA	-	-																															ataaccccatcctactacccAcagagagcggcctgctcact																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:49950962_49950966delACAGA	uc001ruh.1	+	14	2836	c.2576_splice	c.e14-1	p.E859_splice	KCNH3_uc010smj.1_Splice_Site_p.E799_splice	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H						regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						CCTACTACCCACAGAGAGCGGCCTG	0.595													---	---	---								-	49950966	-	-	49950962	8	5	268	1	0	1	0	1	0	0	1	0	8072	174	6	0		0	KCNH3	12	49950962	Splice_Site	DEL	ACAGA	TCGA-CV-7437-01A-21D-2129-08	514998	49950962	83900933	114	48712											
ATF7	11016	broad.mit.edu	37	chr12	53918430	53918430	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctttcgcttttggcggcagCgggaggctgcagcccggttg	3	10	17	11	4	0	0	0	0	0	0	1	1	0	1	1	5	3	6	1	5	0	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:53918430C>A	uc001sdy.2	-	9	1097	c.1076G>T	c.(1075-1077)CGC>CTC	p.R359L	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Missense_Mutation_p.R348L|ATF7_uc010sol.1_Missense_Mutation_p.R327L	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	359	Basic motif.|Essential for binding adenovirus 2 E1A.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						TTGGCGGCAGCGGGAGGCTGC	0.607													33	45					3.03874e-20	3.51854e-20	1	0	A	53918430	A	A	53918430	3	1	268	1	0	0	0	0	1	0	0	0	1088	768	27	3	420	3	ATF7	12	53918430	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	3967468	53918430	79933465	115	48713											
OR10A7	121364	broad.mit.edu	37	chr12	55615608	55615608	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcggcccaaatcaaaccagtCccctgagagcaagaagctag	14	4	10	13	1	1	2	1	1	0	2	2	3	2	2	4	1	3	2	4	1	5	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:55615608C>T	uc010spf.1	+	1	800	c.800C>T	c.(799-801)TCC>TTC	p.S267F		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						TCAAACCAGTCCCCTGAGAGC	0.507													15	76					0	0	0	0	T	55615608	T	T	55615608	3	4	268	1	0	0	0	0	1	0	0	0	10949	855	30	2	802	2	OR10A7	12	55615608	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	1697178	55615608	78236287	116	48714											
DNAJC14	85406	broad.mit.edu	37	chr12	56221350	56221350	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatccagccaagagaagaGccaggtagccttatccctcc	13	6	9	13	0	0	3	0	0	0	3	3	4	3	3	6	1	3	1	6	1	5	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:56221350G>A	uc001shx.1	-	2	1297	c.1093C>T	c.(1093-1095)CTC>TTC	p.L365F	DNAJC14_uc001shu.1_Missense_Mutation_p.L365F|DNAJC14_uc009zob.1_Missense_Mutation_p.L365F|DNAJC14_uc001shy.1_Missense_Mutation_p.L365F	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	365					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						CAAGAGAAGAGCCAGGTAGCC	0.567													22	70					0	0	0	0	A	56221350	A	A	56221350	3	1	268	1	0	0	0	0	1	0	0	0	4655	971	34	4	1039	4	DNAJC14	12	56221350	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	605742	56221350	77630545	117	48715											
TIMELESS	8914	broad.mit.edu	37	chr12	56815168	56815168	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaactttttctgccgtttCttgtacagctcccgccgctc	4	14	7	16	3	2	0	0	0	2	0	4	0	3	0	4	0	4	4	4	0	2	5	rs113553695		TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:56815168C>T	uc001slf.2	-	23	3003	c.2835G>A	c.(2833-2835)AAG>AAA	p.K945K		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	945					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						TCTGCCGTTTCTTGTACAGCT	0.527													75	66					0	0	0	0	T	56815168	T	T	56815168	2	4	268	1	0	0	0	0	0	0	0	1	15970	912	32	2		2	TIMELESS	12	56815168	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	593818	56815168	77036727	118	48716											
TMEM194A	23306	broad.mit.edu	37	chr12	57454716	57454716	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaacaggcttttctgctccCttacacacctttctgtgctc	6	14	7	14	0	2	0	0	0	2	0	4	1	3	1	2	2	4	3	2	2	2	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:57454716C>T	uc001smy.2	-	8	1039	c.993G>A	c.(991-993)AAG>AAA	p.K331K	TMEM194A_uc001smx.2_Silent_p.K258K|TMEM194A_uc010sra.1_Silent_p.K72K	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	331						integral to membrane					0						TTTCTGCTCCCTTACACACCT	0.438													29	76					0	0	0	0	T	57454716	T	T	57454716	2	4	268	1	0	0	0	0	0	0	0	1	16182	680	24	4		4	TMEM194A	12	57454716	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	639548	57454716	76397179	119	48717											
TMTC2	160335	broad.mit.edu	37	chr12	83324299	83324299	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctttgtactaccgcagcAacatggctgacatgctttat	10	13	8	10	1	0	1	0	1	0	0	0	1	0	1	1	1	6	6	1	1	4	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr12:83324299A>G	uc001szt.2	+	4	2005	c.1573A>G	c.(1573-1575)AAC>GAC	p.N525D	TMTC2_uc001szr.1_Missense_Mutation_p.N525D|TMTC2_uc001szs.1_Missense_Mutation_p.N525D|TMTC2_uc010suk.1_Missense_Mutation_p.N280D	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	525	TPR 2.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CTACCGCAGCAACATGGCTGA	0.433													9	43					0	0	0	0	G	83324299	G	G	83324299	3	3	268	1	0	0	0	0	1	0	0	0	16327	130	5	5	1587	5	TMTC2	12	83324299	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08	25869583	83324299	50527596	120	48718											
FREM2	341640	broad.mit.edu	37	chr13	39265184	39265184	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctattacccaattccccactCatggtcacatcatgaatcag	12	11	4	14	0	4	1	4	1	0	0	5	1	5	1	3	1	1	0	3	1	4	3	rs151214132		TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr13:39265184C>A	uc001uwv.2	+	1	4012	c.3703C>A	c.(3703-3705)CAT>AAT	p.H1235N		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1235	CSPG 8.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ATTCCCCACTCATGGTCACAT	0.428													58	258					2.12129e-23	2.48898e-23	1	0	A	39265184	A	A	39265184	3	1	268	1	0	0	0	0	1	0	0	0	6079	826	29	2	3705	2	FREM2	13	39265184	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08		39265184	75904694	121	48719											
GPC5	2262	broad.mit.edu	37	chr13	92380812	92380812	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggatttgtggccgccctgtAagaacacccacacaaagccc	12	6	9	14	1	0	1	0	0	0	1	0	2	0	2	4	2	2	1	4	2	3	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr13:92380812A>T	uc010tif.1	+	4	1413	c.1047A>T	c.(1045-1047)GTA>GTT	p.V349V		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	349						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GCCGCCCTGTAAGAACACCCA	0.423													14	126					0	0	0	0	T	92380812	T	T	92380812	2	4	268	1	0	0	0	0	0	0	0	1	6639	349	13	5		5	GPC5	13	92380812	Silent	SNP	A	TCGA-CV-7437-01A-21D-2129-08	53115628	92380812	22789066	122	48720											
UGGT2	55757	broad.mit.edu	37	chr13	96675306	96675306	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taatttaccttgaagcagctTtcttcagcagctttttaatc	10	17	5	9	0	2	1	1	1	1	0	3	1	2	1	1	0	5	4	1	0	4	9			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr13:96675306T>A	uc001vmt.2	-	4	643	c.473A>T	c.(472-474)AAA>ATA	p.K158I	UGGT2_uc010afo.2_RNA|UGGT2_uc001vmv.2_Missense_Mutation_p.K158I|UGGT2_uc010afp.2_Missense_Mutation_p.K158I	NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	158					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						TGAAGCAGCTTTCTTCAGCAG	0.323													22	56					0	0	0	0	A	96675306	A	A	96675306	3	1	268	1	0	0	0	0	1	0	0	0	17010	1841	64	5	4221	5	UGGT2	13	96675306	Missense_Mutation	SNP	T	TCGA-CV-7437-01A-21D-2129-08	4294494	96675306	18494572	123	48721											
AKAP6	9472	broad.mit.edu	37	chr14	33293503	33293503	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttttgaggcctgtgttgagGgtgactctgatggagaggag	7	13	17	4	0	1	5	0	4	1	1	1	7	1	6	1	4	0	1	1	4	0	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr14:33293503G>A	uc001wrq.2	+	13	6654	c.6484G>A	c.(6484-6486)GGT>AGT	p.G2162S		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2162					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CTGTGTTGAGGGTGACTCTGA	0.478													30	17					0	0	0	0	A	33293503	A	A	33293503	3	1	268	1	0	0	0	0	1	0	0	0	455	1232	43	4	6530	4	AKAP6	14	33293503	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		33293503	74056037	124	48722											
C14orf37	145407	broad.mit.edu	37	chr14	58471868	58471868	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctccagctatcccaaccccTacaggcaccagcatcccaga	11	5	6	19	0	0	1	0	0	0	1	3	1	3	1	6	1	4	4	6	1	3	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr14:58471868T>G	uc001xdc.2	-	7	2265	c.2154A>C	c.(2152-2154)GTA>GTC	p.V718V	C14orf37_uc010tro.1_Silent_p.V756V|C14orf37_uc001xdd.2_Silent_p.V718V	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	718	Helical; (Potential).					integral to membrane	binding				0						TCCCAACCCCTACAGGCACCA	0.488													47	50					0	0	0	0	G	58471868	G	G	58471868	2	3	268	1	0	0	0	0	0	0	0	1	1777	1509	53	5		5	C14orf37	14	58471868	Silent	SNP	T	TCGA-CV-7437-01A-21D-2129-08	25178365	58471868	48877672	125	48723											
SNAPC1	6617	broad.mit.edu	37	chr14	62233670	62233672	+	In_Frame_Del	DEL	CCA	-	-																															cttggcgatattttttacctCcatacaccttccagatcaga																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr14:62233670_62233672delCCA	uc001xft.2	+	2	309_311	c.205_207delCCA	c.(205-207)CCAdel	p.P69del		NM_003082	NP_003073	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex,	69	SNAPC3-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)		TTTTTTACCTCCATACACCTTCC	0.33													---	---	---								-	62233672	-	-	62233670	7	5	268	1	0	1	0	1	0	0	0	0	14898	855	30	0	211	0	SNAPC1	14	62233670	In_Frame_Del	DEL	CCA	TCGA-CV-7437-01A-21D-2129-08	3761802	62233670	45115870	126	48724											
FCF1	51077	broad.mit.edu	37	chr14	75182665	75182665	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccttcagtccccaacaccCttcctgcttatttttccaat	7	16	2	16	0	1	0	1	0	0	0	5	0	5	0	6	0	2	1	6	0	3	6	rs114572906	by1000genomes	TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr14:75182665C>G	uc001xqh.2	+	4	206	c.155C>G	c.(154-156)CCT>CGT	p.P52R	KIAA0317_uc001xqb.2_5'Flank|KIAA0317_uc010tut.1_5'Flank|KIAA0317_uc001xqc.2_5'Flank|KIAA0317_uc001xqd.1_5'Flank|FCF1_uc001xqf.1_Missense_Mutation_p.P37R|FCF1_uc001xqg.2_RNA|FCF1_uc001xqi.2_RNA	NM_015962	NP_057046	Q9Y324	FCF1_HUMAN	FCF1 small subunit	52					rRNA processing	nucleolus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0037)		CCCCAACACCCTTCCTGCTTA	0.373													12	178					0	0	0	0	G	75182665	G	G	75182665	3	3	268	1	0	0	0	0	1	0	0	0	5809	681	24	4	169	4	FCF1	14	75182665	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	12948995	75182665	32166875	127	48725											
KCNK13	56659	broad.mit.edu	37	chr14	90650616	90650616	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtgccaccagcggcagctcCggagacgaggggccctgccc	6	3	15	17	4	0	1	0	0	0	1	1	3	1	1	5	4	4	2	5	4	0	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr14:90650616C>T	uc001xye.1	+	2	938	c.496C>T	c.(496-498)CGG>TGG	p.R166W		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	166	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				GCGGCAGCTCCGGAGACGAGG	0.612													5	76					0	0	0	0	T	90650616	T	T	90650616	3	4	268	1	0	0	0	0	1	0	0	0	8100	643	23	1	502	1	KCNK13	14	90650616	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	15467951	90650616	16698924	128	48726											
DICER1	23405	broad.mit.edu	37	chr14	95584087	95584087	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtttgccagcttcctttaTcaatctaagaaaattataca	13	16	4	8	0	2	1	1	0	1	1	3	1	3	1	2	0	3	2	2	0	7	8	rs141163928		TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr14:95584087T>C	uc001ydw.2	-	10	1563	c.1381A>G	c.(1381-1383)ATA>GTA	p.I461V	DICER1_uc001ydv.2_Missense_Mutation_p.I451V|DICER1_uc001ydx.2_Missense_Mutation_p.I461V	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	461	Helicase C-terminal.|Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GCTTCCTTTATCAATCTAAGA	0.348			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				8	43					0	0	0	0	C	95584087	C	C	95584087	3	2	268	1	0	0	0	0	1	0	0	0	4543	1435	50	5	4463	5	DICER1	14	95584087	Missense_Mutation	SNP	T	TCGA-CV-7437-01A-21D-2129-08	4933471	95584087	11765453	129	48727											
SEMA6D	80031	broad.mit.edu	37	chr15	48063143	48063143	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgaagagccactcagaaaagGcccatggccatggagcttca	13	6	11	11	0	2	3	2	1	0	2	2	4	2	4	3	3	2	1	3	3	3	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr15:48063143G>T	uc010bek.2	+	19	2743	c.2383G>T	c.(2383-2385)GCC>TCC	p.A795S	SEMA6D_uc001zvw.2_Missense_Mutation_p.A733S|SEMA6D_uc001zvy.2_Missense_Mutation_p.A795S|SEMA6D_uc001zvz.2_Missense_Mutation_p.A739S|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Missense_Mutation_p.A733S|SEMA6D_uc001zwc.2_Missense_Mutation_p.A720S	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	795	Cytoplasmic (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CTCAGAAAAGGCCCATGGCCA	0.542													24	53					5.45024e-15	6.10982e-15	1	0	T	48063143	T	T	48063143	3	4	268	1	0	0	0	0	1	0	0	0	14107	1203	42	4	2496	4	SEMA6D	15	48063143	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		48063143	54468249	130	48728											
EFTUD1	79631	broad.mit.edu	37	chr15	82456255	82456259	+	Frame_Shift_Del	DEL	AAATG	-	-																															gcttcgaagttgagtggtatAaatggtgggcaggatggcag																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr15:82456255_82456259delAAATG	uc002bgt.1	-	16	1986_1990	c.1817_1821delCATTT	c.(1816-1821)CCATTTfs	p.P606fs	EFTUD1_uc002bgu.1_Frame_Shift_Del_p.P555fs	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	606_607					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						TGAGTGGTATAAATGGTGGGCAGGA	0.4													---	---	---								-	82456259	-	-	82456255	7	5	268	1	0	1	0	1	0	0	0	0	4982	359	13	0	1561	0	EFTUD1	15	82456255	Frame_Shift_Del	DEL	AAATG	TCGA-CV-7437-01A-21D-2129-08	34393112	82456255	20075137	131	48729											
TAOK2	9344	broad.mit.edu	37	chr16	29993064	29993064	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacgaatcccccgtgctccaGtcaggacactggtgaggact	10	7	11	13	2	1	1	1	1	0	0	3	4	3	3	3	3	2	1	3	3	2	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr16:29993064G>T	uc002dva.1	+	9	1521	c.738G>T	c.(736-738)CAG>CAT	p.Q246H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.Q246H|TAOK2_uc002dvc.1_Missense_Mutation_p.Q246H|TAOK2_uc010bzm.1_Missense_Mutation_p.Q246H|TAOK2_uc002dvd.1_Missense_Mutation_p.Q73H	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	246	Protein kinase.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CCGTGCTCCAGTCAGGACACT	0.542													14	59					7.93312e-07	8.36065e-07	1	0	T	29993064	T	T	29993064	3	4	268	1	0	0	0	0	1	0	0	0	15614	1020	36	4	768	4	TAOK2	16	29993064	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		29993064	60361689	132	48730											
ZFPM1	161882	broad.mit.edu	37	chr16	88598407	88598408	+	Splice_Site	INS	-	AGAAG	AGAAG																															ccgcctgcttcccaccccacINSagaagacgtcttcccctgca																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr16:88598407_88598408insAGAAG	uc002fkv.2	+	7	746	c.713_splice	c.e7-2	p.K238_splice		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1						blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TCCCACCCCACAGAAGACGTCT	0.698													---	---	---								AGAAG	88598408	AGAAG	AGAAG	88598407	8	5	268	1	0	1	1	0	0	0	1	0	17724	493	17	0		0	ZFPM1	16	88598407	Splice_Site	INS	-	TCGA-CV-7437-01A-21D-2129-08	58605343	88598407	1756346	133	48731											
TP53	7157	broad.mit.edu	37	chr17	7579336	7579336	+	Frame_Shift_Del	DEL	C	-	-																															caagtcacagacttggctgtCccagaatgcaagaagcccag																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr17:7579336delC	uc002gim.2	-	4	545	c.351delG	c.(349-351)GGGfs	p.G117fs	TP53_uc002gig.1_Frame_Shift_Del_p.G117fs|TP53_uc002gih.2_Frame_Shift_Del_p.G117fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.G117fs|TP53_uc010cni.1_Frame_Shift_Del_p.G117fs|TP53_uc002gij.2_Frame_Shift_Del_p.G117fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.G78fs|TP53_uc010cnk.1_Frame_Shift_Del_p.G132fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	117	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> E (in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G59fs*23(3)|p.G117E(2)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G112_V122delGFLHSGTAKSV(1)|p.T118fs*27(1)|p.H115fs*27(1)|p.T118fs*6(1)|p.Y107fs*44(1)|p.G117R(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.T118fs*5(1)|p.T118fs*31(1)|p.L114fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACTTGGCTGTCCCAGAATGCA	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7579336	-	-	7579336	7	5	268	1	0	1	0	1	0	0	0	0	16448	842	30	0	951	0	TP53	17	7579336	Frame_Shift_Del	DEL	C	TCGA-CV-7437-01A-21D-2129-08		7579336	73615874	134	48732											
NOS2	4843	broad.mit.edu	37	chr17	26114800	26114800	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccctgggtcctctggtcaaaCttttgggagtcataatggac	8	12	11	10	0	3	0	2	0	1	0	4	2	4	2	2	4	1	0	2	4	2	3	rs148763708	byFrequency	TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr17:26114800C>T	uc002gzu.2	-	5	635	c.371G>A	c.(370-372)AGT>AAT	p.S124N	NOS2_uc010crh.1_Missense_Mutation_p.S124N|NOS2_uc010wab.1_Missense_Mutation_p.S124N	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	124					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TCTGGTCAAACTTTTGGGAGT	0.498													6	164					0	0	0	0	T	26114800	T	T	26114800	3	4	268	1	0	0	0	0	1	0	0	0	10597	565	20	4	3182	4	NOS2	17	26114800	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	18535464	26114800	55080410	135	48733											
ABCA5	23461	broad.mit.edu	37	chr17	67302927	67302927	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttatttttttttctttttCtgctacgatatgaattgcca	7	24	4	6	1	2	1	0	1	2	0	2	2	2	1	1	0	3	1	1	0	4	11			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr17:67302927C>T	uc002jif.2	-	5	1945	c.727G>A	c.(727-729)GAA>AAA	p.E243K	ABCA5_uc002jig.2_Missense_Mutation_p.E243K|ABCA5_uc002jih.2_Missense_Mutation_p.E243K|ABCA5_uc010dfe.2_Missense_Mutation_p.E243K	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	243					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					TTTTCTTTTTCTGCTACGATA	0.249													13	32					0	0	0	0	T	67302927	T	T	67302927	3	4	268	1	0	0	0	0	1	0	0	0	35	922	32	2	4337	2	ABCA5	17	67302927	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	41188127	67302927	13892283	136	48734											
FAM104A	84923	broad.mit.edu	37	chr17	71223343	71223343	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaaagacagggtttctgctActtcttttggtctggggggg	6	14	15	6	0	3	2	0	1	3	1	3	2	3	2	0	5	2	2	0	5	2	5			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr17:71223343A>G	uc002jji.3	-	2	370	c.282T>C	c.(280-282)AGT>AGC	p.S94S	FAM104A_uc002jjj.3_Silent_p.S94S	NM_032837	NP_116226	Q969W3	F104A_HUMAN	hypothetical protein LOC84923 isoform 2	94	Ser-rich.										0			LUSC - Lung squamous cell carcinoma(166;0.197)			GGTTTCTGCTACTTCTTTTGG	0.408													20	103					0	0	0	0	G	71223343	G	G	71223343	2	3	268	1	0	0	0	0	0	0	0	1	5413	388	14	5		5	FAM104A	17	71223343	Silent	SNP	A	TCGA-CV-7437-01A-21D-2129-08	3920416	71223343	9971867	137	48735											
LAMA1	284217	broad.mit.edu	37	chr18	6943269	6943269	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccaactgcgttcccgtcaaCaatcagagtgatacggtgtt	10	10	10	11	3	2	2	2	1	0	1	3	2	3	2	2	1	4	2	2	1	4	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr18:6943269C>A	uc002knm.2	-	62	9071	c.8977G>T	c.(8977-8979)GTT>TTT	p.V2993F	LAMA1_uc002knk.2_Missense_Mutation_p.V323F|LAMA1_uc002knl.2_Missense_Mutation_p.V446F|LAMA1_uc010wzj.1_Missense_Mutation_p.V2469F	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2993	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCCCGTCAACAATCAGAGTG	0.488													99	30					1.54295e-31	1.84734e-31	1	0	A	6943269	A	A	6943269	3	1	268	1	0	0	0	0	1	0	0	0	8645	478	17	4	258	4	LAMA1	18	6943269	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08		6943269	71133979	138	48736											
SS18	6760	broad.mit.edu	37	chr18	23619368	23619369	+	Frame_Shift_Ins	INS	-	C	C																															cttggtaatgctgtccgcctINSccctgtggcatattgtattg																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr18:23619368_23619369insC	uc002kvm.2	-	6	737_738	c.659_660insG	c.(658-660)GGAfs	p.G220fs	SS18_uc002kvn.2_Frame_Shift_Ins_p.G220fs|SS18_uc010xbf.1_Frame_Shift_Ins_p.G138fs|SS18_uc010xbg.1_Frame_Shift_Ins_p.G168fs|SS18_uc010xbh.1_Frame_Shift_Ins_p.G168fs|SS18_uc010xbi.1_Frame_Shift_Ins_p.G197fs|SS18_uc010dlz.1_Frame_Shift_Ins_p.G168fs	NM_001007559	NP_001007560	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	220	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					GCTGTCCGCCTCCCTGTGGCAT	0.426			T	SSX1| SSX2	synovial sarcoma								---	---	---								C	23619369	C	C	23619368	7	5	268	1	0	1	1	0	0	0	0	0	15241	1538	54	0	620	0	SS18	18	23619368	Frame_Shift_Ins	INS	-	TCGA-CV-7437-01A-21D-2129-08	16676099	23619368	54457880	139	48737											
CDH20	28316	broad.mit.edu	37	chr18	59166671	59166671	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acaatgagcccaagttcctgGacggaccttatgtggccact	10	9	10	12	1	0	1	0	1	0	0	1	3	1	3	4	3	1	1	4	3	3	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr18:59166671G>A	uc010dps.1	+	2	511	c.499G>A	c.(499-501)GAC>AAC	p.D167N	CDH20_uc002lif.2_Missense_Mutation_p.D161N	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	167	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				CAAGTTCCTGGACGGACCTTA	0.483													14	42					0	0	0	0	A	59166671	A	A	59166671	3	1	268	1	0	0	0	0	1	0	0	0	3121	1174	41	2	505	2	CDH20	18	59166671	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	35547303	59166671	18910577	140	48738											
KCNG2	26251	broad.mit.edu	37	chr18	77659522	77659522	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgtcatctccatgaccacCgtgggctacggcgacatggt	7	8	12	14	4	2	1	1	1	1	0	3	2	2	1	4	3	1	1	4	3	1	1	rs3744887		TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr18:77659522C>T	uc010xfl.1	+	2	1107	c.1107C>T	c.(1105-1107)ACC>ACT	p.T369T		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	369	Selectivity filter (By similarity).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CCATGACCACCGTGGGCTACG	0.706													25	15					0	0	0	0	T	77659522	T	T	77659522	2	4	268	1	0	0	0	0	0	0	0	1	8067	639	23	1		1	KCNG2	18	77659522	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	18492851	77659522	417726	141	48739											
DOT1L	84444	broad.mit.edu	37	chr19	2223362	2223362	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctcccctgtgccctaccAggaccacgaccagccccccg	7	4	9	21	2	0	0	0	0	0	0	1	3	1	1	9	1	4	1	9	1	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr19:2223362A>G	uc002lvb.3	+	25	3509	c.3473A>G	c.(3472-3474)CAG>CGG	p.Q1158R	DOT1L_uc002lvc.1_Missense_Mutation_p.Q452R	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1158						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCCCTACCAGGACCACGAC	0.622													11	62					0	0	0	0	G	2223362	G	G	2223362	3	3	268	1	0	0	0	0	1	0	0	0	4731	188	7	5	3571	5	DOT1L	19	2223362	Missense_Mutation	SNP	A	TCGA-CV-7437-01A-21D-2129-08		2223362	56905621	142	48740											
TICAM1	148022	broad.mit.edu	37	chr19	4816803	4816803	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcctgaagcctgtggggCttgaaggtgttggccacctt	5	10	16	10	1	0	2	0	2	0	0	0	2	0	2	4	5	1	2	4	5	2	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr19:4816803C>A	uc002mbi.2	-	2	1838	c.1587G>T	c.(1585-1587)AAG>AAT	p.K529N		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	529	Sufficient to induce apoptosis.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GCCTGTGGGGCTTGAAGGTGT	0.657													13	23					7.93312e-07	8.36065e-07	1	0	A	4816803	A	A	4816803	3	1	268	1	0	0	0	0	1	0	0	0	15958	796	28	4	555	4	TICAM1	19	4816803	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	2593441	4816803	54312180	143	48741											
FUT5	2527	broad.mit.edu	37	chr19	5867388	5867388	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtgcacgatgaccgcgtCtgcctgtgggtacacactgg	6	9	15	11	3	1	1	0	1	1	0	1	2	1	1	2	3	3	2	2	3	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr19:5867388C>T	uc002mdo.3	-	2	437	c.349G>A	c.(349-351)GAC>AAC	p.D117N	FUT5_uc010duo.2_Missense_Mutation_p.D117N	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	117	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						ATGACCGCGTCTGCCTGTGGG	0.642													21	38					0	0	0	0	T	5867388	T	T	5867388	3	4	268	1	0	0	0	0	1	0	0	0	6141	913	32	2	779	2	FUT5	19	5867388	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	1050585	5867388	53261595	144	48742											
SLC1A6	6511	broad.mit.edu	37	chr19	15072831	15072831	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caccagataatgatgcccacCagcctcataatagcctcatt	13	9	5	14	0	2	2	2	1	0	1	2	2	2	2	5	0	3	0	5	0	3	4			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr19:15072831C>A	uc002naa.1	-	5	926	c.918G>T	c.(916-918)CTG>CTT	p.L306L	SLC1A6_uc010dzu.1_Silent_p.L306L|SLC1A6_uc010xod.1_Silent_p.L242L|SLC1A6_uc002nab.2_Silent_p.L306L|SLC1A6_uc002nac.2_Silent_p.L306L	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	306	Helical; (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	TGATGCCCACCAGCCTCATAA	0.572													4	92					0.00909568	0.00920023	1	0	A	15072831	A	A	15072831	2	1	268	1	0	0	0	0	0	0	0	1	14501	581	21	4		4	SLC1A6	19	15072831	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	9205443	15072831	44056152	145	48743											
CYP4F12	66002	broad.mit.edu	37	chr19	15784508	15784508	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtttcccacagcccccaaaaCggaactggttttggggtcac	9	9	10	13	1	1	0	1	0	0	0	2	1	2	1	3	4	3	2	3	4	3	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr19:15784508C>T	uc002nbl.2	+	2	230	c.169C>T	c.(169-171)CGG>TGG	p.R57W	CYP4F12_uc010xoo.1_Missense_Mutation_p.R57W|CYP4F12_uc010xop.1_Missense_Mutation_p.R57W	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					GCCCCCAAAACGGAACTGGTT	0.592													6	123					0	0	0	0	T	15784508	T	T	15784508	3	4	268	1	0	0	0	0	1	0	0	0	4204	527	19	1	171	1	CYP4F12	19	15784508	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	711677	15784508	43344475	146	48744											
FCGBP	8857	broad.mit.edu	37	chr19	40408592	40408592	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccacctcctcccaggagttgCcgaactcattggcgttgcct	6	10	9	16	2	1	0	1	0	0	0	3	2	3	1	6	2	3	2	6	2	1	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr19:40408592C>T	uc002omp.3	-	8	4255	c.4247G>A	c.(4246-4248)GGC>GAC	p.G1416D		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1416	VWFD 3.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCAGGAGTTGCCGAACTCATT	0.637													70	35					0	0	0	0	T	40408592	T	T	40408592	3	4	268	1	0	0	0	0	1	0	0	0	5810	739	26	4	12086	4	FCGBP	19	40408592	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	24624084	40408592	18720391	147	48745											
RPL13A	23521	broad.mit.edu	37	chr19	49993179	49993179	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggctaaacaggtactgctgGgtaagtcgctgctcgtggcc	7	10	14	10	2	0	0	0	0	0	0	2	0	0	0	1	4	4	6	1	4	4	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr19:49993179G>A	uc002pny.2	+	2	110	c.88G>A	c.(88-90)GGC>AGC	p.G30S	RPL13A_uc002pnz.2_Intron|RPL13A_uc002poa.2_Nonsense_Mutation_p.W20*|SNORD32A_uc010emy.1_5'Flank|SNORD33_uc010emz.1_5'Flank|SNORD34_uc010ena.1_5'Flank|SNORD35A_uc010enb.1_5'Flank	NM_012423	NP_036555	P40429	RL13A_HUMAN	ribosomal protein L13a	30					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		GGTACTGCTGGGTAAGTCGCT	0.592													38	100					0	0	0	0	A	49993179	A	A	49993179	3	1	268	1	0	0	0	0	1	0	0	0	13625	1246	43	4	94	4	RPL13A	19	49993179	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	9584587	49993179	9135804	148	48746											
SYT5	6861	broad.mit.edu	37	chr19	55687172	55687172	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtccggcagcaggtagacccGcacataggggtccgaggagc	9	4	16	12	3	0	1	0	0	0	1	2	3	2	2	3	5	2	4	3	5	2	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr19:55687172G>A	uc002qjm.1	-	4	1505	c.445C>T	c.(445-447)CGG>TGG	p.R149W	SYT5_uc002qjp.2_Missense_Mutation_p.R146W|SYT5_uc002qjn.1_Missense_Mutation_p.R149W|SYT5_uc002qjo.1_Missense_Mutation_p.R149W	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	149	Cytoplasmic (Potential).|C2 1.				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		AGGTAGACCCGCACATAGGGG	0.622													27	82					0	0	0	0	A	55687172	A	A	55687172	3	1	268	1	0	0	0	0	1	0	0	0	15543	1086	38	1	735	1	SYT5	19	55687172	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	5693993	55687172	3441811	149	48747											
SBK2	646643	broad.mit.edu	37	chr19	56042631	56042631	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tggctgagtgcgcgcccagcGagagccccacacagaactcg	9	4	13	15	4	0	3	0	1	0	2	1	4	0	3	3	1	4	1	3	1	1	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr19:56042631G>C	uc010ygc.1	-	2	335	c.335C>G	c.(334-336)TCG>TGG	p.S112W		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	112	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0						CGCGCCCAGCGAGAGCCCCAC	0.667													5	24					0	0	0	0	C	56042631	C	C	56042631	3	2	268	1	0	0	0	0	1	0	0	0	13926	1059	37	3	718	3	SBK2	19	56042631	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	355459	56042631	3086352	150	48748											
PLCB1	23236	broad.mit.edu	37	chr20	8745992	8745992	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggaaaagtccgccaaaaagGacagtaagaaaaagtaagtt	20	6	10	5	1	0	1	0	0	0	1	1	3	1	3	2	2	0	3	2	2	8	3			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr20:8745992G>T	uc002wnb.2	+	26	2920	c.2917G>T	c.(2917-2919)GAC>TAC	p.D973Y	PLCB1_uc010zrb.1_Missense_Mutation_p.D872Y|PLCB1_uc002wna.2_Missense_Mutation_p.D973Y|PLCB1_uc002wnc.1_Missense_Mutation_p.D872Y|PLCB1_uc002wnd.1_Missense_Mutation_p.D550Y	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	973					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CGCCAAAAAGGACAGTAAGAA	0.328													31	27					7.63505e-26	9.01858e-26	1	0	T	8745992	T	T	8745992	3	4	268	1	0	0	0	0	1	0	0	0	12082	1174	41	2	3019	2	PLCB1	20	8745992	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		8745992	54279528	151	48749											
SSTR4	6754	broad.mit.edu	37	chr20	23016973	23016973	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagctgctgaacctcttcGtgaccagccttgatgccacc	7	10	9	15	1	1	3	0	3	1	0	2	3	1	3	5	0	6	3	5	0	1	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr20:23016973G>A	uc002wsr.2	+	1	917	c.853G>A	c.(853-855)GTG>ATG	p.V285M		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	285	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GAACCTCTTCGTGACCAGCCT	0.552													42	127					0	0	0	0	A	23016973	A	A	23016973	3	1	268	1	0	0	0	0	1	0	0	0	15266	1145	40	1	855	1	SSTR4	20	23016973	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	14270981	23016973	40008547	152	48750											
TTLL9	164395	broad.mit.edu	37	chr20	30486334	30486334	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacacactcatggacgtcCttcgccacaggccaggatgg	10	7	11	13	2	1	1	1	1	0	0	3	3	2	3	3	4	1	0	3	4	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr20:30486334C>T	uc010gdx.1	+	4	425	c.172C>T	c.(172-174)CTT>TTT	p.L58F	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_RNA|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Missense_Mutation_p.P67L|TTLL9_uc010ztp.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	58	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CATGGACGTCCTTCGCCACAG	0.522													24	45					0	0	0	0	T	30486334	T	T	30486334	3	4	268	1	0	0	0	0	1	0	0	0	16802	681	24	4	182	4	TTLL9	20	30486334	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	7469361	30486334	32539186	153	48751											
C20orf186	149954	broad.mit.edu	37	chr20	31677343	31677343	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgctgggtcttgtcaatGaccagctgggcctcgtggat	5	12	15	9	1	2	1	1	1	1	0	3	2	2	2	2	4	2	2	2	4	1	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr20:31677343G>C	uc010zue.1	+	7	1045	c.1030G>C	c.(1030-1032)GAC>CAC	p.D344H		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	344						cytoplasm|extracellular region	lipid binding				0						TCTTGTCAATGACCAGCTGGG	0.582													54	66					0	0	0	0	C	31677343	C	C	31677343	3	2	268	1	0	0	0	0	1	0	0	0	2108	1290	45	2	1056	2	C20orf186	20	31677343	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08	1191009	31677343	31348177	154	48752											
ATP9A	10079	broad.mit.edu	37	chr20	50234077	50234077	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattcctgaatcatgctgacGtcattgcctccgtcccctgc	6	12	8	15	2	2	2	2	2	0	0	5	3	5	2	5	0	3	1	5	0	1	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr20:50234077G>A	uc002xwg.1	-	22	2367	c.2367C>T	c.(2365-2367)GAC>GAT	p.D789D	ATP9A_uc010gih.1_Silent_p.D653D|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	789	Cytoplasmic (Potential).	Magnesium (By similarity).			ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TCATGCTGACGTCATTGCCTC	0.498													6	11					0	0	0	0	A	50234077	A	A	50234077	2	1	268	1	0	0	0	0	0	0	0	1	1200	1136	40	1		1	ATP9A	20	50234077	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	18556734	50234077	12791443	155	48753											
LIPI	149998	broad.mit.edu	37	chr21	15538694	15538694	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagtatacctgagaaaattGatttaggacagccaggttgt	13	12	10	6	0	1	2	1	2	0	1	1	4	1	3	2	2	2	2	2	2	5	6			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr21:15538694G>C	uc002yjm.2	-	5	795	c.785C>G	c.(784-786)TCA>TGA	p.S262*	LIPI_uc010gkw.1_Intron	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	241					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TGAGAAAATTGATTTAGGACA	0.358													21	57					0	0	0	0	C	15538694	C	C	15538694	4	2	268	1	0	0	0	0	0	1	0	0	8867	1294	45	2	684	2	LIPI	21	15538694	Nonsense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		15538694	32591201	156	48754											
CECR2	27443	broad.mit.edu	37	chr22	18022469	18022469	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcagggaggggactccatGatggacagcccagagatgat	11	6	16	8	0	0	3	0	2	0	1	1	7	1	6	2	4	2	1	2	4	0	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr22:18022469G>T	uc010gqw.1	+	15	2697	c.2571G>T	c.(2569-2571)ATG>ATT	p.M857I	CECR2_uc010gqv.1_Missense_Mutation_p.M716I|CECR2_uc002zml.2_Missense_Mutation_p.M716I	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	899					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		GGGACTCCATGATGGACAGCC	0.637													26	61					2.44723e-14	2.70888e-14	1	0	T	18022469	T	T	18022469	3	4	268	1	0	0	0	0	1	0	0	0	3221	1290	45	2	2631	2	CECR2	22	18022469	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		18022469	33282097	157	48755											
LZTR1	8216	broad.mit.edu	37	chr22	21349206	21349206	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtcccacttcaaccaggtGatcatgatgaaggagttcga	12	9	11	9	1	2	3	2	3	0	0	4	6	3	4	2	2	1	1	2	2	2	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr22:21349206G>A	uc002zto.2	+	16	1936	c.1833G>A	c.(1831-1833)GTG>GTA	p.V611V	LZTR1_uc002ztn.2_Silent_p.V570V|LZTR1_uc011ahy.1_Silent_p.V592V|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	611					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TCAACCAGGTGATCATGATGA	0.617													51	108					0	0	0	0	A	21349206	A	A	21349206	2	1	268	1	0	0	0	0	0	0	0	1	9188	1277	45	2		2	LZTR1	22	21349206	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	3326737	21349206	29955360	158	48756											
MN1	4330	broad.mit.edu	37	chr22	28196406	28196418	+	Frame_Shift_Del	DEL	CCCAGTGTGGAAA	-	-																															tccacagggccagggggcccCccagtgtggaaagccggggc																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr22:28196406_28196418delCCCAGTGTGGAAA	uc003adj.2	-	1	1069_1081	c.114_126delTTTCCACACTGGG	c.(112-126)GCTTTCCACACTGGGfs	p.A38fs		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	38_42							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						CAGGGGGCCCCCCAGTGTGGAAAGCCGGGGCCT	0.634			T	ETV6	AML|meningioma								---	---	---								-	28196418	-	-	28196406	7	5	268	1	0	1	0	1	0	0	0	0	9726	610	22	0	3844	0	MN1	22	28196406	Frame_Shift_Del	DEL	CCCAGTGTGGAAA	TCGA-CV-7437-01A-21D-2129-08	6847200	28196406	23108160	159	48757											
MYH9	4627	broad.mit.edu	37	chr22	36698676	36698678	+	In_Frame_Del	DEL	GGA	-	-																															gtaggcagcgcagttccgctGgaggaccttcatggcggtaa																										TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr22:36698676_36698678delGGA	uc003apg.2	-	20	2666_2668	c.2435_2437delTCC	c.(2434-2439)CTCCAG>CAG	p.L812del	MYH9_uc003aph.1_In_Frame_Del_p.L676del	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	812					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CAGTTCCGCTGGAGGACCTTCAT	0.542			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				---	---	---								-	36698678	-	-	36698676	7	5	268	1	0	1	0	1	0	0	0	0	10095	1357	47	0	3533	0	MYH9	22	36698676	In_Frame_Del	DEL	GGA	TCGA-CV-7437-01A-21D-2129-08	8502270	36698676	14605890	160	48758											
SEPT3	55964	broad.mit.edu	37	chr22	42383247	42383247	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcaaaatgaagctgaccgtCatcgacaccccaggctttgg	11	8	10	12	2	2	2	2	2	0	0	3	3	2	2	3	2	1	2	3	2	3	1			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr22:42383247C>T	uc003bbr.3	+	4	507	c.369C>T	c.(367-369)GTC>GTT	p.V123V	WBP2NL_uc011ape.1_Intron|SEPT3_uc003bbs.3_Silent_p.V123V|SEPT3_uc010gyr.2_Silent_p.V59V|SEPT3_uc011apj.1_Silent_p.V59V|SEPT3_uc010gys.2_Intron	NM_145733	NP_663786	Q9UH03	SEPT3_HUMAN	septin 3 isoform A	123					cell cycle|cytokinesis	cell junction|septin complex	GTP binding				0						AGCTGACCGTCATCGACACCC	0.493													22	54					0	0	0	0	T	42383247	T	T	42383247	2	4	268	1	0	0	0	0	0	0	0	1	14130	813	29	2		2	SEPT3	22	42383247	Silent	SNP	C	TCGA-CV-7437-01A-21D-2129-08	5684571	42383247	8921319	161	48759											
GRAMD4	23151	broad.mit.edu	37	chr22	47054120	47054120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcgagaagaaaccaacgCggagatgctgcggcaggagc	12	3	16	10	4	0	3	0	0	0	3	0	6	0	4	1	3	6	3	1	3	3	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chr22:47054120C>T	uc003bhx.2	+	3	359	c.320C>T	c.(319-321)GCG>GTG	p.A107V	GRAMD4_uc010had.2_Missense_Mutation_p.A46V	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	107	Potential.				apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		GAAACCAACGCGGAGATGCTG	0.657													10	42					0	0	0	0	T	47054120	T	T	47054120	3	4	268	1	0	0	0	0	1	0	0	0	6791	768	27	1	330	1	GRAMD4	22	47054120	Missense_Mutation	SNP	C	TCGA-CV-7437-01A-21D-2129-08	4670873	47054120	4250446	162	48760											
GLRA2	2742	broad.mit.edu	37	chrX	14748410	14748410	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccaagtgaaagatggaacaGctgtcaaggccacacctgcc	13	6	10	12	0	1	2	1	1	0	1	2	3	2	3	4	2	3	1	4	2	4	0			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chrX:14748410G>A	uc010nep.2	+	10	1494	c.1162G>A	c.(1162-1164)GCT>ACT	p.A388T	GLRA2_uc010neq.2_Missense_Mutation_p.A388T|GLRA2_uc004cwe.3_Missense_Mutation_p.A388T|GLRA2_uc011mio.1_Missense_Mutation_p.A299T|GLRA2_uc011mip.1_Missense_Mutation_p.A366T	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	388	Cytoplasmic (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	AGATGGAACAGCTGTCAAGGC	0.473													7	172					0	0	0	0	A	14748410	A	A	14748410	3	1	268	1	0	0	0	0	1	0	0	0	6492	971	34	4	1268	4	GLRA2	23	14748410	Missense_Mutation	SNP	G	TCGA-CV-7437-01A-21D-2129-08		14748410	140522150	163	48761											
ASB9	140462	broad.mit.edu	37	chrX	15270437	15270437	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggttgaacgctggctccGtgctgcagaagcaaattcac	10	9	11	11	2	2	2	2	1	0	1	3	2	3	2	1	2	4	6	1	2	3	2			TCGA-CV-7437-01A-21D-2129-08	TCGA-CV-7437-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	53413980-80cc-4c73-8bb6-31a01d6df86e	8e46f3c1-520c-4518-a734-4579dfcd97a3	g.chrX:15270437G>A	uc004cwl.2	-	4	619	c.372C>T	c.(370-372)CAC>CAT	p.H124H	ASB9_uc004cwk.2_Silent_p.H124H|ASB9_uc004cwm.2_Silent_p.H124H|ASB9_uc010ner.2_Silent_p.H124H|ASB9_uc004cwn.2_Silent_p.H95H	NM_001031739	NP_001026909	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box-containing 9 isoform	124	ANK 3.				intracellular signal transduction						0	Hepatocellular(33;0.183)					CGCTGGCTCCGTGCTGCAGAA	0.478													46	13					0	0	0	0	A	15270437	A	A	15270437	2	1	268	1	0	0	0	0	0	0	0	1	1032	1136	40	1		1	ASB9	23	15270437	Silent	SNP	G	TCGA-CV-7437-01A-21D-2129-08	522027	15270437	140000123	164	48762											
EPHA2	1969	broad.mit.edu	37	chr1	16475205	16475210	+	In_Frame_Del	DEL	TTCAGC	-	-																															ccacggagcgctcctccacgTtcagcttcacgtggcgtgcc																								rs146626026	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:16475205_16475210delTTCAGC	uc001aya.1	-	3	623_628	c.486_491delGCTGAA	c.(484-492)AAGCTGAAC>AAC	p.KL162del	EPHA2_uc010oca.1_In_Frame_Del_p.KL162del	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	162_163	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CTCCTCCACGTTCAGCTTCACGTGGC	0.612													---	---	---								-	16475210	-	-	16475205	7	5	269	1	0	1	0	1	0	0	0	0	5191	1725	60	0	2499	0	EPHA2	1	16475205	In_Frame_Del	DEL	TTCAGC	TCGA-CV-7438-01A-21D-2129-08		16475205	232775416	1	48763											
UBR4	23352	broad.mit.edu	37	chr1	19478948	19478948	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaagtcaatggggaaagtCacctggctagacgtgcgggt	13	7	14	7	2	2	1	2	0	0	1	2	2	2	2	1	4	1	1	1	4	5	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:19478948C>T	uc001bbi.2	-	47	6859	c.6855G>A	c.(6853-6855)GTG>GTA	p.V2285V	UBR4_uc001bbk.1_5'Flank|UBR4_uc001bbl.1_Silent_p.V222V|UBR4_uc001bbm.1_Silent_p.V1497V	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2285					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGGGGAAAGTCACCTGGCTAG	0.507													8	153					0	0	0	0	T	19478948	T	T	19478948	2	4	269	1	0	0	0	0	0	0	0	1	16972	813	29	2		2	UBR4	1	19478948	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	3003743	19478948	229771673	2	48764											
C1orf38	9473	broad.mit.edu	37	chr1	28208651	28208651	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggaggttcctgagggccgCcccatcttcctcagcccgtg	4	9	12	16	2	2	1	1	1	1	0	4	2	4	2	6	3	1	1	6	3	0	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:28208651C>G	uc001bpc.3	+	4	844	c.816C>G	c.(814-816)CGC>CGG	p.R272R	C1orf38_uc001boz.2_Intron|C1orf38_uc001bpa.2_Intron|C1orf38_uc010ofn.1_Intron|C1orf38_uc010ofo.1_Intron	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	272	CABIT 2.				cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		CTGAGGGCCGCCCCATCTTCC	0.632													14	35					0	0	0	0	G	28208651	G	G	28208651	2	3	269	1	0	0	0	0	0	0	0	1	2049	726	26	4		4	C1orf38	1	28208651	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	8729703	28208651	221041970	3	48765											
KHDRBS1	10657	broad.mit.edu	37	chr1	32498892	32498892	+	Frame_Shift_Del	DEL	T	-	-																															cccatgtgaggcttatgctcTtatggcccatgccatggagg																										TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:32498892delT	uc001bub.2	+	4	834	c.728delT	c.(727-729)CTTfs	p.L243fs	KHDRBS1_uc001bua.1_Frame_Shift_Del_p.L204fs|KHDRBS1_uc001buc.1_RNA	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal	243					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GCTTATGCTCTTATGGCCCAT	0.458													---	---	---								-	32498892	-	-	32498892	7	5	269	1	0	1	0	1	0	0	0	0	8185	1609	56	0	742	0	KHDRBS1	1	32498892	Frame_Shift_Del	DEL	T	TCGA-CV-7438-01A-21D-2129-08	4290241	32498892	216751729	4	48766											
COL9A2	1298	broad.mit.edu	37	chr1	40775985	40775985	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtagcccctgatgccctggGgaccctgttgagaaagaaaa	11	7	13	10	0	0	3	0	2	0	2	0	5	0	4	4	3	2	2	4	3	4	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:40775985G>A	uc001cfh.1	-	14	759	c.689C>T	c.(688-690)CCC>CTC	p.P230L	COL9A2_uc001cfi.1_Missense_Mutation_p.P49L	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	230	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			GATGCCCTGGGGACCCTGTTG	0.378													6	71					0	0	0	0	A	40775985	A	A	40775985	3	1	269	1	0	0	0	0	1	0	0	0	3723	1232	43	4	1456	4	COL9A2	1	40775985	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	8277093	40775985	208474636	5	48767											
PTGFR	5737	broad.mit.edu	37	chr1	78958948	78958948	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgctgcccatccttggaCatcgagactataaaattcag	11	12	7	11	1	1	1	1	0	0	1	3	3	2	2	2	1	2	1	2	1	3	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:78958948C>T	uc001din.2	+	2	786	c.520C>T	c.(520-522)CAT>TAT	p.H174Y	PTGFR_uc001dim.2_Missense_Mutation_p.H174Y	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	174	Helical; Name=4; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CATCCTTGGACATCGAGACTA	0.368													11	131					0	0	0	0	T	78958948	T	T	78958948	3	4	269	1	0	0	0	0	1	0	0	0	12812	478	17	4	522	4	PTGFR	1	78958948	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	38182963	78958948	170291673	6	48768											
WDR63	126820	broad.mit.edu	37	chr1	85560225	85560225	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttctggagcttctctgatcCtatacatcctcaggtaatta	9	16	6	10	0	3	1	1	1	2	0	6	2	5	2	2	2	2	2	2	2	4	6			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:85560225C>T	uc001dkt.2	+	10	1351	c.1160C>T	c.(1159-1161)CCT>CTT	p.P387L	WDR63_uc009wcl.2_Missense_Mutation_p.P348L	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	387										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TTCTCTGATCCTATACATCCT	0.383													6	183					0	0	0	0	T	85560225	T	T	85560225	3	4	269	1	0	0	0	0	1	0	0	0	17382	681	24	4	1194	4	WDR63	1	85560225	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	6601277	85560225	163690396	7	48769											
CLCA4	22802	broad.mit.edu	37	chr1	87031654	87031654	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttctcattgctgaagaTcagtcaaagaattgtgtgct	10	15	9	7	0	4	3	3	1	2	2	5	3	4	3	0	0	2	2	0	0	3	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:87031654T>C	uc009wcs.2	+	6	949	c.905T>C	c.(904-906)ATC>ACC	p.I302T	CLCA4_uc009wct.2_Missense_Mutation_p.I65T|CLCA4_uc009wcu.2_Missense_Mutation_p.I122T	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	302						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TTGCTGAAGATCAGTCAAAGA	0.413													25	84					0	0	0	0	C	87031654	C	C	87031654	3	2	269	1	0	0	0	0	1	0	0	0	3474	1435	50	5	927	5	CLCA4	1	87031654	Missense_Mutation	SNP	T	TCGA-CV-7438-01A-21D-2129-08	1471429	87031654	162218967	8	48770											
SLC6A17	388662	broad.mit.edu	37	chr1	110709557	110709557	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcccaggtggcatcaatgccGaagaacagcaaagtgaccca	14	4	11	12	1	1	2	1	1	0	1	1	3	1	2	3	2	3	2	3	2	4	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:110709557G>A	uc009wfq.2	+	2	467	c.6G>A	c.(4-6)CCG>CCA	p.P2P		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	2	Cytoplasmic (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		CATCAATGCCGAAGAACAGCA	0.572													12	11					0	0	0	0	A	110709557	A	A	110709557	2	1	269	1	0	0	0	0	0	0	0	1	14744	1045	37	1		1	SLC6A17	1	110709557	Silent	SNP	G	TCGA-CV-7438-01A-21D-2129-08	23677903	110709557	138541064	9	48771											
NBPF15	284565	broad.mit.edu	37	chr1	148594513	148594513	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgactcattccagcactacaGaagtgtgttttactcatttg	10	15	7	9	0	2	2	2	1	0	1	3	2	3	2	1	0	3	2	1	0	3	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:148594513G>A	uc001esc.2	+	19	2375	c.1886G>A	c.(1885-1887)AGA>AAA	p.R629K		NM_173638	NP_775909	Q8N660	NBPFF_HUMAN	hypothetical protein LOC284565	629	NBPF 6.					cytoplasm					0	all_hematologic(923;0.032)					CAGCACTACAGAAGTGTGTTT	0.438													18	421					0	0	0	0	A	148594513	A	A	148594513	3	1	269	1	0	0	0	0	1	0	0	0	10249	942	33	2	1944	2	NBPF15	1	148594513	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	37884956	148594513	100656108	10	48772											
FCRL4	83417	broad.mit.edu	37	chr1	157557115	157557115	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttgtggatgttacccctCactgtttcagcaccacacca	8	12	7	14	0	2	0	2	0	0	0	2	1	2	1	4	1	3	4	4	1	1	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:157557115C>G	uc001fqw.2	-	5	934	c.798G>C	c.(796-798)GTG>GTC	p.V266V	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	266	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				TGTTACCCCTCACTGTTTCAG	0.572													108	218					0	0	0	0	G	157557115	G	G	157557115	2	3	269	1	0	0	0	0	0	0	0	1	5829	813	29	2		2	FCRL4	1	157557115	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	8962602	157557115	91693506	11	48773											
CFHR4	10877	broad.mit.edu	37	chr1	196871631	196871631	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gactatactttccagcagctGcaggacaatcttattcctat	11	13	6	11	0	1	0	0	0	1	0	3	2	3	1	2	1	4	3	2	1	5	6			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:196871631G>T	uc001gto.2	+	2	211	c.142G>T	c.(142-144)GCA>TCA	p.A48S	CFHR4_uc009wyy.2_Missense_Mutation_p.A47S|CFHR4_uc001gtp.2_Missense_Mutation_p.A48S	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	48	Sushi 1.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						TCCAGCAGCTGCAGGACAATC	0.363													20	117					4.35082e-09	4.82033e-09	1	0	T	196871631	T	T	196871631	3	4	269	1	0	0	0	0	1	0	0	0	3302	1319	46	4	148	4	CFHR4	1	196871631	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	39314516	196871631	52378990	12	48774											
USH2A	7399	broad.mit.edu	37	chr1	215955425	215955425	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcaaccgtgcaagctttcaGctgatatgaatattcctgaa	13	11	8	9	1	1	3	1	3	0	0	2	3	2	3	2	0	5	4	2	0	6	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr1:215955425G>T	uc001hku.1	-	54	11086	c.10699C>A	c.(10699-10701)CTG>ATG	p.L3567M		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3567	Extracellular (Potential).|Fibronectin type-III 20.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAAGCTTTCAGCTGATATGAA	0.438										HNSCC(13;0.011)			26	64					2.41591e-17	2.75593e-17	1	0	T	215955425	T	T	215955425	3	4	269	1	0	0	0	0	1	0	0	0	17104	962	34	4	4985	4	USH2A	1	215955425	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	19083794	215955425	33295196	13	48775											
VIT	5212	broad.mit.edu	37	chr2	37028521	37028521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacagccatagagaaaattaCtcagagaggaggactttcta	16	8	10	7	0	2	2	1	0	1	2	2	7	2	4	1	2	2	0	1	2	5	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:37028521C>T	uc002rpl.2	+	13	1357	c.1136C>T	c.(1135-1137)ACT>ATT	p.T379I	VIT_uc002rpm.2_Missense_Mutation_p.T357I|VIT_uc010ezv.2_Missense_Mutation_p.T335I|VIT_uc010ezw.2_Missense_Mutation_p.T336I	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	364	VWFA 1.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				GAGAAAATTACTCAGAGAGGA	0.393													13	167					0	0	0	0	T	37028521	T	T	37028521	3	4	269	1	0	0	0	0	1	0	0	0	17239	565	20	4	1307	4	VIT	2	37028521	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08		37028521	206170852	14	48776											
GGCX	2677	broad.mit.edu	37	chr2	85779683	85779683	+	Frame_Shift_Del	DEL	G	-	-																															ccttccatcgccgactctgtGtaaatacctgccccaaaccc																										TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:85779683delG	uc002sps.2	-	10	1401	c.1295delC	c.(1294-1296)ACAfs	p.T432fs	GGCX_uc010yss.1_Frame_Shift_Del_p.T271fs|GGCX_uc010yst.1_Frame_Shift_Del_p.T375fs	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	432	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	CCGACTCTGTGTAAATACCTG	0.512											OREG0014747	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	85779683	-	-	85779683	7	5	269	1	0	1	0	1	0	0	0	0	6393	1377	48	0	1005	0	GGCX	2	85779683	Frame_Shift_Del	DEL	G	TCGA-CV-7438-01A-21D-2129-08	48751162	85779683	157419690	15	48777											
CNGA3	1261	broad.mit.edu	37	chr2	99013475	99013475	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagacaacctgatcgatgaGgagctggccagggcgggcgc	11	4	16	10	3	0	3	0	2	0	1	1	5	0	4	2	4	2	1	2	4	2	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:99013475G>A	uc002syt.2	+	8	2259	c.1842G>A	c.(1840-1842)GAG>GAA	p.E614E	CNGA3_uc002syu.2_Silent_p.E596E|CNGA3_uc010fij.2_Silent_p.E618E	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	614					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						TGATCGATGAGGAGCTGGCCA	0.622													9	18					0	0	0	0	A	99013475	A	A	99013475	2	1	269	1	0	0	0	0	0	0	0	1	3613	991	35	4		4	CNGA3	2	99013475	Silent	SNP	G	TCGA-CV-7438-01A-21D-2129-08	13233792	99013475	144185898	16	48778			1	74		2	2	19	N	G_C	7.209808e-05
CNGA3	1261	broad.mit.edu	37	chr2	99013493	99013493	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggagctggccagggcgggCgcggaccccaaggaccttga	8	3	18	12	3	0	1	0	1	0	0	0	5	0	4	4	6	1	1	4	6	1	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:99013493C>T	uc002syt.2	+	8	2277	c.1860C>T	c.(1858-1860)GGC>GGT	p.G620G	CNGA3_uc002syu.2_Silent_p.G602G|CNGA3_uc010fij.2_Silent_p.G624G	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	620					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CCAGGGCGGGCGCGGACCCCA	0.622													3	17					0	0	0	0	T	99013493	T	T	99013493	2	4	269	1	0	0	0	0	0	0	0	1	3613	755	27	1		1	CNGA3	2	99013493	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	18	99013493	144185880	17	48779			1	74		2	2	19	N	G_C	7.209808e-05
EPB41L5	57669	broad.mit.edu	37	chr2	120925517	120925517	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgacagggaaggagggacAtggtaataaagatggaatct	15	9	14	3	0	1	2	0	1	1	1	1	6	1	6	0	5	0	1	0	5	5	3	rs143558813	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:120925517A>C	uc002tmg.2	+	24	2195	c.2069A>C	c.(2068-2070)CAT>CCT	p.H690P	EPB41L5_uc010fll.2_Intron|EPB41L5_uc010flm.2_Missense_Mutation_p.H493P	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	690						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1						AAGGAGGGACATGGTAATAAA	0.453													5	100					0	0	0	0	C	120925517	C	C	120925517	3	2	269	1	0	0	0	0	1	0	0	0	5181	217	8	5	2344	5	EPB41L5	2	120925517	Missense_Mutation	SNP	A	TCGA-CV-7438-01A-21D-2129-08	21912024	120925517	122273856	18	48780											
NEB	4703	broad.mit.edu	37	chr2	152539240	152539240	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggacccaaaaggcacccagCcacaacctttcatccagcta	14	5	6	16	0	1	0	1	0	0	0	2	1	2	1	5	2	3	2	5	2	4	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:152539240C>G	uc010fnx.2	-	29	3070	c.2879G>C	c.(2878-2880)GGC>GCC	p.G960A		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	960	Nebulin 23.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGGCACCCAGCCACAACCTTT	0.438													3	19					0	0	0	0	G	152539240	G	G	152539240	3	3	269	1	0	0	0	0	1	0	0	0	10356	739	26	4	23423	4	NEB	2	152539240	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	31613723	152539240	90660133	19	48781											
HOXD3	3232	broad.mit.edu	37	chr2	177036312	177036312	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtacgcacggcatacacgagCgcgcagctggtggaattgga	10	6	15	10	5	0	0	0	0	0	0	0	3	0	2	0	4	4	5	0	4	3	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:177036312C>T	uc002ukt.1	+	3	785	c.609C>T	c.(607-609)AGC>AGT	p.S203S		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	203	Homeobox.				anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		CATACACGAGCGCGCAGCTGG	0.642													11	35					0	0	0	0	T	177036312	T	T	177036312	2	4	269	1	0	0	0	0	0	0	0	1	7362	767	27	1		1	HOXD3	2	177036312	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	24497072	177036312	66163061	20	48782											
FN1	2335	broad.mit.edu	37	chr2	216274717	216274717	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgagtcacttcttggtggcCgtactgctggatgctgatga	6	12	14	9	2	2	2	1	2	1	0	2	4	2	3	1	3	3	3	1	3	1	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:216274717C>T	uc002vfa.2	-	14	2328	c.2062G>A	c.(2062-2064)GGC>AGC	p.G688S	FN1_uc002vfb.2_Missense_Mutation_p.G688S|FN1_uc002vfc.2_Missense_Mutation_p.G688S|FN1_uc002vfd.2_Missense_Mutation_p.G688S|FN1_uc002vfe.2_Missense_Mutation_p.G688S|FN1_uc002vff.2_Missense_Mutation_p.G688S|FN1_uc002vfg.2_Missense_Mutation_p.G688S|FN1_uc002vfh.2_Missense_Mutation_p.G688S|FN1_uc002vfi.2_Missense_Mutation_p.G688S|FN1_uc002vfj.2_Missense_Mutation_p.G688S	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	688	Fibronectin type-III 1.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTTGGTGGCCGTACTGCTGG	0.552													19	94					0	0	0	0	T	216274717	T	T	216274717	3	4	269	1	0	0	0	0	1	0	0	0	5994	652	23	1	5503	1	FN1	2	216274717	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	39238405	216274717	26924656	21	48783											
NHEJ1	79840	broad.mit.edu	37	chr2	220033735	220033735	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccacccttatcccttctcAcctccagatacccacctcct	8	10	1	22	0	1	1	1	0	1	1	5	1	4	1	8	0	1	0	8	0	2	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:220033735A>T	uc002vjq.3	-	4		c.580_splice	c.e4+1		SLC23A3_uc010zkr.1_Intron|SLC23A3_uc010zks.1_Intron|SLC23A3_uc010fwb.2_Intron|SLC23A3_uc002vjs.1_Intron|SLC23A3_uc002vjt.1_Intron			Q9H9Q4	NHEJ1_HUMAN	Synthetic construct DNA, clone: pF1KE1061, Homo sapiens NHEJ1 gene for nonhomologous end-joining factor 1, without stop codon, in Flexi system.						B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			lung(1)	1		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)		ATCCCTTCTCACCTCCAGATA	0.557								Direct_reversal_of_damage|NHEJ					12	31					0	0	0	0	T	220033735	T	T	220033735	5	4	269	1	0	0	0	0	0	0	1	0	10456	174	6	5		5	NHEJ1	2	220033735	Splice_Site	SNP	A	TCGA-CV-7438-01A-21D-2129-08	3759018	220033735	23165638	22	48784											
NCL	4691	broad.mit.edu	37	chr2	232326268	232326285	+	In_Frame_Del	DEL	TCGTCATCCTCATCATCT	-	-																															taccatcttcctcatcgtcaTcgtcatcctcatcatcttcg																								rs80005798	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr2:232326268_232326285delTCGTCATCCTCATCATCT	uc002vru.2	-	3	720_737	c.579_596delAGATGATGAGGATGACGA	c.(577-597)GAAGATGATGAGGATGACGAT>GAT	p.EDDEDD193del	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	193_198	Asp/Glu-rich (acidic).				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		ctcatcgtcatcgtcatcctcatcatcttcgtcatcct	0.289													---	---	---								-	232326285	-	-	232326268	7	5	269	1	0	1	0	1	0	0	0	0	10280	1435	50	0	1584	0	NCL	2	232326268	In_Frame_Del	DEL	TCGTCATCCTCATCATCT	TCGA-CV-7438-01A-21D-2129-08	12292533	232326268	10873105	23	48785											
CPNE9	151835	broad.mit.edu	37	chr3	9757188	9757188	+	Missense_Mutation	SNP	A	T	T																															tcggaagaaatgtaagaagaAgaaatatgtcaactcaggaa																										TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:9757188A>T	uc003bsd.2	+	12	971	c.800A>T	c.(799-801)AAG>ATG	p.K267M		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	267	Poly-Lys.									ovary(2)	2	Medulloblastoma(99;0.227)					TGTAAGAAGAAGAAATATGTC	0.433													25	43					0	0	0	0	T	9757188	T	T	9757188	3	4	269	1	0	0	0	0	1	0	0	0	3834	72	3	5	846	5	CPNE9	3	9757188	Missense_Mutation	SNP	A	TCGA-CV-7438-01A-21D-2129-08		9757188	188265242	24	48786	108	2									
CPNE9	151835	broad.mit.edu	37	chr3	9757198	9757198	+	Silent	SNP	C	T	T																															tgtaagaagaagaaatatgtCaactcaggaactgtgagtgc																										TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:9757198C>T	uc003bsd.2	+	12	981	c.810C>T	c.(808-810)GTC>GTT	p.V270V		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	270										ovary(2)	2	Medulloblastoma(99;0.227)					AGAAATATGTCAACTCAGGAA	0.408													21	35					0	0	0	0	T	9757198	T	T	9757198	2	4	269	1	0	0	0	0	0	0	0	1	3834	813	29	2		2	CPNE9	3	9757198	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	10	9757198	188265232	25	48787	108	2									
TGM4	7047	broad.mit.edu	37	chr3	44952543	44952543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tatcagaggtttcatcattgCggaaattgtggagtctaagg	11	13	12	5	1	4	1	3	0	1	1	4	3	4	3	0	4	1	1	0	4	3	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:44952543C>T	uc003coc.3	+	12	1773	c.1700C>T	c.(1699-1701)GCG>GTG	p.A567V		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	567					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TTCATCATTGCGGAAATTGTG	0.453													14	61					0	0	0	0	T	44952543	T	T	44952543	3	4	269	1	0	0	0	0	1	0	0	0	15898	768	27	1	1746	1	TGM4	3	44952543	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	35195345	44952543	153069887	26	48788											
SETD2	29072	broad.mit.edu	37	chr3	47098467	47098467	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttgaatcccaaacactataAttctgtccctgaactgggcc	11	12	6	12	0	1	2	0	2	1	0	3	2	3	2	3	1	2	0	3	1	5	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:47098467A>C	uc003cqs.2	-	15	6860	c.6807T>G	c.(6805-6807)AAT>AAG	p.N2269K	SETD2_uc003cqv.2_Missense_Mutation_p.N2336K|SETD2_uc003cqt.1_RNA	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2269	Gln-rich.|Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AAACACTATAATTCTGTCCCT	0.512			N|F|S|Mis		clear cell renal carcinoma								17	48					0	0	0	0	C	47098467	C	C	47098467	3	2	269	1	0	0	0	0	1	0	0	0	14196	98	4	5	915	5	SETD2	3	47098467	Missense_Mutation	SNP	A	TCGA-CV-7438-01A-21D-2129-08	2145924	47098467	150923963	27	48789											
USP4	7375	broad.mit.edu	37	chr3	49362439	49362439	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcacgctccgcagggatgTtgaatagcttccgcatctct	7	13	9	12	3	2	1	1	1	1	0	5	2	4	2	2	1	1	5	2	1	2	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:49362439T>G	uc003cwq.2	-	5	600	c.521A>C	c.(520-522)AAC>ACC	p.N174T	USP4_uc003cwr.2_Missense_Mutation_p.N174T	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	174					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		CGCAGGGATGTTGAATAGCTT	0.498													21	109					0	0	0	0	G	49362439	G	G	49362439	3	3	269	1	0	0	0	0	1	0	0	0	17139	1725	60	5	2442	5	USP4	3	49362439	Missense_Mutation	SNP	T	TCGA-CV-7438-01A-21D-2129-08	2263972	49362439	148659991	28	48790											
TWF2	11344	broad.mit.edu	37	chr3	52263196	52263196	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggaactctgccgtcagctCtgccccatcgccaatctcaa	9	8	8	16	2	4	0	2	0	3	0	6	2	4	1	4	1	4	1	4	1	3	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:52263196C>T	uc003ddd.2	-	9	1055	c.904G>A	c.(904-906)GAG>AAG	p.E302K	TLR9_uc003ddb.2_Intron|TLR9_uc003ddc.1_Intron|TWF2_uc010hmc.2_3'UTR	NM_007284	NP_009215	Q6IBS0	TWF2_HUMAN	twinfilin-like protein	302	ADF-H 2.					cytoskeleton|perinuclear region of cytoplasm	actin binding|ATP binding			stomach(1)|ovary(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;2.43e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCCGTCAGCTCTGCCCCATCG	0.652													4	60					0	0	0	0	T	52263196	T	T	52263196	3	4	269	1	0	0	0	0	1	0	0	0	16850	922	32	2	149	2	TWF2	3	52263196	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	2900757	52263196	145759234	29	48791											
SFMBT1	51460	broad.mit.edu	37	chr3	52941219	52941219	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggagcatgactttttttCtgacatttctgattcttcct	8	18	7	8	0	3	4	0	3	3	1	4	5	4	5	1	1	1	1	1	1	0	6			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:52941219C>G	uc003dgf.2	-	20	2766	c.2197G>C	c.(2197-2199)GAA>CAA	p.E733Q	SFMBT1_uc010hmr.2_Missense_Mutation_p.E680Q|SFMBT1_uc003dgg.2_Missense_Mutation_p.E733Q|SFMBT1_uc003dgh.2_Missense_Mutation_p.E733Q	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	733					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		GACTTTTTTTCTGACATTTCT	0.463													8	87					0	0	0	0	G	52941219	G	G	52941219	3	3	269	1	0	0	0	0	1	0	0	0	14222	922	32	2	415	2	SFMBT1	3	52941219	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	678023	52941219	145081211	30	48792											
EPHA6	285220	broad.mit.edu	37	chr3	97202858	97202858	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cagtccatgaatttgcaaagGagattgatccctcaagaatt	14	11	8	8	0	1	4	1	2	0	2	3	5	3	4	2	1	1	1	2	1	4	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:97202858G>C	uc010how.1	+	10	2198	c.2155G>C	c.(2155-2157)GAG>CAG	p.E719Q	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Missense_Mutation_p.E85Q|EPHA6_uc003drs.3_Missense_Mutation_p.E111Q|EPHA6_uc003drr.3_Missense_Mutation_p.E111Q|EPHA6_uc003drt.2_Missense_Mutation_p.E111Q|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	624	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.A719S(1)		stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						ATTTGCAAAGGAGATTGATCC	0.308													10	25					0	0	0	0	C	97202858	C	C	97202858	3	2	269	1	0	0	0	0	1	0	0	0	5195	1175	41	2	2261	2	EPHA6	3	97202858	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	44261639	97202858	100819572	31	48793											
IMPG2	50939	broad.mit.edu	37	chr3	100963246	100963246	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actagtttcttgtcttcaatCtcagctggcaaaagtgaatc	11	14	7	9	0	4	1	2	1	3	0	6	1	4	1	0	1	1	3	0	1	5	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:100963246C>T	uc003duq.1	-	13	2132	c.1929G>A	c.(1927-1929)GAG>GAA	p.E643E	IMPG2_uc011bhe.1_Silent_p.E506E	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	643	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TGTCTTCAATCTCAGCTGGCA	0.413													28	90					0	0	0	0	T	100963246	T	T	100963246	2	4	269	1	0	0	0	0	0	0	0	1	7768	912	32	2		2	IMPG2	3	100963246	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	3760388	100963246	97059184	32	48794											
PODXL2	50512	broad.mit.edu	37	chr3	127379692	127379692	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacagtgctgccagctgcagGgcttggggtagagttcgagg	7	8	17	9	1	0	1	0	0	0	1	1	2	0	1	1	4	4	6	1	4	1	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:127379692G>A	uc003ejq.2	+	3	845	c.821G>A	c.(820-822)GGG>GAG	p.G274E		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	274	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						CCAGCTGCAGGGCTTGGGGTA	0.637													7	45					0	0	0	0	A	127379692	A	A	127379692	3	1	269	1	0	0	0	0	1	0	0	0	12236	1232	43	4	831	4	PODXL2	3	127379692	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	26416446	127379692	70642738	33	48795											
EEFSEC	60678	broad.mit.edu	37	chr3	128127010	128127010	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaggcaggaggagagcgccGagcggagcgagccctcacag	10	1	17	13	4	1	1	1	0	0	1	1	6	1	3	3	4	4	1	3	4	0	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:128127010G>A	uc003eki.2	+	7	1737	c.1699G>A	c.(1699-1701)GAG>AAG	p.E567K	EEFSEC_uc003ekj.2_3'UTR	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	567						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GGAGAGCGCCGAGCGGAGCGA	0.647													3	43					0	0	0	0	A	128127010	A	A	128127010	3	1	269	1	0	0	0	0	1	0	0	0	4953	1059	37	1	1725	1	EEFSEC	3	128127010	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	747318	128127010	69895420	34	48796											
IFT122	55764	broad.mit.edu	37	chr3	129180117	129180117	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctacaatcctattactcatCaactggcatcttgttcctcc	9	14	3	15	0	3	0	2	0	1	0	6	0	6	0	4	1	3	2	4	1	5	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:129180117C>T	uc003emm.2	+	5	525	c.319C>T	c.(319-321)CAA>TAA	p.Q107*	IFT122_uc003eml.2_Nonsense_Mutation_p.Q158*|IFT122_uc003emn.2_Nonsense_Mutation_p.Q107*|IFT122_uc003emo.2_Intron|IFT122_uc003emp.2_5'UTR|IFT122_uc010htc.2_Nonsense_Mutation_p.Q158*|IFT122_uc011bky.1_5'UTR|IFT122_uc003emq.2_Intron|IFT122_uc003emr.2_5'Flank|IFT122_uc011bla.1_5'Flank|IFT122_uc011bkx.1_Intron|IFT122_uc011bkz.1_5'Flank	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	107	WD 3.				camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						TATTACTCATCAACTGGCATC	0.398													15	53					0	0	0	0	T	129180117	T	T	129180117	4	4	269	1	0	0	0	0	0	1	0	0	7594	827	29	2	494	2	IFT122	3	129180117	Nonsense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	1053107	129180117	68842313	35	48797											
PIK3CA	5290	broad.mit.edu	37	chr3	178937422	178937422	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctatggaacttctggacTgtaattacccagatcctatg	11	12	9	9	0	1	1	0	0	1	1	2	3	2	3	2	3	2	2	2	3	5	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:178937422T>C	uc003fjk.2	+	12	1967	c.1810T>C	c.(1810-1812)TGT>CGT	p.C604R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	604	PI3K helical.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACTTCTGGACTGTAATTACCC	0.368		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			13	35					0	0	0	0	C	178937422	C	C	178937422	3	2	269	1	0	0	0	0	1	0	0	0	11968	1580	55	5	1852	5	PIK3CA	3	178937422	Missense_Mutation	SNP	T	TCGA-CV-7438-01A-21D-2129-08	49757305	178937422	19085008	36	48798											
DVL3	1857	broad.mit.edu	37	chr3	183882981	183882981	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcggcggaagcagaaggtttCtcggattgagcgggtatggg	8	8	19	6	4	1	2	0	1	1	1	2	4	1	4	0	6	2	3	0	6	3	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr3:183882981C>T	uc003fms.2	+	6	820	c.680C>T	c.(679-681)TCT>TTT	p.S227F	DVL3_uc011bqw.1_Missense_Mutation_p.S227F|DVL3_uc003fmt.2_5'UTR|DVL3_uc003fmu.2_Missense_Mutation_p.S59F	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	227					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CAGAAGGTTTCTCGGATTGAG	0.597													13	30					0	0	0	0	T	183882981	T	T	183882981	3	4	269	1	0	0	0	0	1	0	0	0	4859	913	32	2	702	2	DVL3	3	183882981	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	4945559	183882981	14139449	37	48799											
ZNF718	255403	broad.mit.edu	37	chr4	154749	154749	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttggacagtgcagggcataGaagattcattccacaaactt	13	11	9	8	0	1	2	1	0	0	2	2	3	2	3	1	2	2	2	1	2	3	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr4:154749G>C	uc003fzt.3	+	8	407	c.274G>C	c.(274-276)GAA>CAA	p.E92Q	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_5'UTR	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		GCAGGGCATAGAAGATTCATT	0.328													9	39					0	0	0	0	C	154749	C	C	154749	3	2	269	1	0	0	0	0	1	0	0	0	18187	943	33	2	288	2	ZNF718	4	154749	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08		154749	190999527	38	48800											
WFS1	7466	broad.mit.edu	37	chr4	6303197	6303197	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggcctggggctgctccgcGcctccatcggctacttcctc	2	9	11	19	4	0	0	0	0	0	0	5	0	3	0	6	4	2	3	6	4	1	2	rs55814513	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr4:6303197G>A	uc003giy.2	+	8	1841	c.1675G>A	c.(1675-1677)GCC>ACC	p.A559T	WFS1_uc003gix.2_Missense_Mutation_p.A559T|WFS1_uc003giz.2_Missense_Mutation_p.A377T	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	559					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		GCTGCTCCGCGCCTCCATCGG	0.652													6	100					0	0	0	0	A	6303197	A	A	6303197	3	1	269	1	0	0	0	0	1	0	0	0	17428	1087	38	1	1701	1	WFS1	4	6303197	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	6148448	6303197	184851079	39	48801											
CDH10	1008	broad.mit.edu	37	chr5	24488189	24488189	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagctcacaatgttgtctctGatatcttcttttgacaagat	10	17	6	8	0	4	3	1	2	3	1	5	3	4	3	0	0	1	2	0	0	4	6			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:24488189G>C	uc003jgr.1	-	12	2282	c.1950C>G	c.(1948-1950)ATC>ATG	p.I650M	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	650	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TGTTGTCTCTGATATCTTCTT	0.428										HNSCC(23;0.051)			6	51					0	0	0	0	C	24488189	C	C	24488189	3	2	269	1	0	0	0	0	1	0	0	0	3111	1280	45	2	420	2	CDH10	5	24488189	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08		24488189	156427071	40	48802											
SV2C	22987	broad.mit.edu	37	chr5	75427937	75427937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgatgagtacaaggaccggcGggagctggaatcagaaagga	14	4	16	7	3	1	2	1	1	0	1	1	7	1	6	1	5	2	2	1	5	4	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:75427937G>A	uc003kei.1	+	2	496	c.362G>A	c.(361-363)CGG>CAG	p.R121Q		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	121	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		AAGGACCGGCGGGAGCTGGAA	0.547													7	49					0	0	0	0	A	75427937	A	A	75427937	3	1	269	1	0	0	0	0	1	0	0	0	15485	1116	39	1	364	1	SV2C	5	75427937	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	50939748	75427937	105487323	41	48803											
PCDHA3	56145	broad.mit.edu	37	chr5	140180884	140180884	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggccagctccactactcCgtctctgaggaggccaagca	9	6	11	15	2	1	1	0	1	1	0	4	2	3	2	4	3	4	2	4	3	2	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:140180884C>A	uc003lhf.2	+	1	102	c.102C>A	c.(100-102)TCC>TCA	p.S34S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.S34S	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	34	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCACTACTCCGTCTCTGAGG	0.667													26	73					1.85244e-09	2.06722e-09	1	0	A	140180884	A	A	140180884	2	1	269	1	0	0	0	0	0	0	0	1	11579	639	23	3		3	PCDHA3	5	140180884	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	64752947	140180884	40734376	42	48804											
PCDHB14	56122	broad.mit.edu	37	chr5	140605383	140605383	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagttcaaatttctgaagcCgattatccccaattttcaag	12	14	6	9	1	3	2	2	2	1	0	4	3	4	2	3	0	1	1	3	0	5	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:140605383C>A	uc003ljb.2	+	1	2306	c.2306C>A	c.(2305-2307)CCG>CAG	p.P769Q	PCDHB14_uc011dal.1_Missense_Mutation_p.P616Q	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	769	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTCTGAAGCCGATTATCCCC	0.453													8	90					5.4927e-09	6.04197e-09	1	0	A	140605383	A	A	140605383	3	1	269	1	0	0	0	0	1	0	0	0	11593	652	23	3	2308	3	PCDHB14	5	140605383	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	424499	140605383	40309877	43	48805											
SLIT3	6586	broad.mit.edu	37	chr5	168112816	168112816	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggcgaagcctggtgggcagCggcaggtgggctcctgctgc	4	6	19	12	3	0	0	0	0	0	0	1	1	1	0	2	6	4	4	2	6	1	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:168112816C>T	uc003mab.2	-	31	3851	c.3431G>A	c.(3430-3432)CGC>CAC	p.R1144H	SLIT3_uc010jjg.2_Missense_Mutation_p.R1151H	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1144	EGF-like 6.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGTGGGCAGCGGCAGGTGGG	0.647													4	20					0	0	0	0	T	168112816	T	T	168112816	3	4	269	1	0	0	0	0	1	0	0	0	14805	768	27	1	1164	1	SLIT3	5	168112816	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	27507433	168112816	12802444	44	48806											
TBC1D9B	23061	broad.mit.edu	37	chr5	179321452	179321452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggtacagccagccctgccGgggcacgcggcccttccagt	6	5	13	17	3	0	0	0	0	0	0	1	0	1	0	5	4	4	2	5	4	1	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr5:179321452G>A	uc003mlh.2	-	4	548	c.511C>T	c.(511-513)CGG>TGG	p.R171W	TBC1D9B_uc003mli.2_Missense_Mutation_p.R171W|TBC1D9B_uc003mlj.2_Missense_Mutation_p.R171W	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	171	GRAM 1.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGCCCTGCCGGGGCACGCGG	0.627													3	41					0	0	0	0	A	179321452	A	A	179321452	3	1	269	1	0	0	0	0	1	0	0	0	15694	1115	39	1	3317	1	TBC1D9B	5	179321452	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	11208636	179321452	1593808	45	48807											
HIST1H2AA	221613	broad.mit.edu	37	chr6	25727627	25727628	+	5'Flank	INS	-	T	T																															gtagtttctaaccgtaagggINSttttttttttttttgaggcg																								rs61603783		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:25727627_25727628insT	uc003nfc.2	-							NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa						nucleosome assembly	nucleosome|nucleus	DNA binding				0						AACCGTAAGGGttttttttttt	0.203													---	---	---								T	25727628	T	T	25727627	6	5	269	0	1	1	1	0	0	0	0	0	7167	1276	44	0		0	HIST1H2AA	6	25727627	5'Flank	INS	-	TCGA-CV-7438-01A-21D-2129-08		25727627	145387440	46	48808											
SLC39A7	7922	broad.mit.edu	37	chr6	33169860	33169860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcttccagaacctcattctCaccacactctggagcaaccc	10	10	4	17	0	4	1	2	0	3	1	6	2	5	2	4	1	3	1	4	1	2	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:33169860C>G	uc003odf.2	+	4	709	c.592C>G	c.(592-594)CAC>GAC	p.H198D	RXRB_uc003odb.2_5'Flank|RXRB_uc003odc.2_5'Flank|RXRB_uc003odd.2_5'Flank|RXRB_uc011dqr.1_5'Flank|RXRB_uc011dqs.1_5'Flank|RXRB_uc011dqt.1_5'Flank|RXRB_uc011dqu.1_5'Flank|SLC39A7_uc003odg.2_Missense_Mutation_p.H198D|SLC39A7_uc011dqv.1_Missense_Mutation_p.H73D|SLC39A7_uc003odh.2_5'Flank|HSD17B8_uc003odi.1_5'Flank	NM_001077516	NP_001070984	Q92504	S39A7_HUMAN	solute carrier family 39, member 7	198						endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			large_intestine(1)	1						ACCTCATTCTCACCACACTCT	0.527													13	68					0	0	0	0	G	33169860	G	G	33169860	3	3	269	1	0	0	0	0	1	0	0	0	14687	826	29	2	602	2	SLC39A7	6	33169860	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	7442233	33169860	137945207	47	48809											
DAXX	1616	broad.mit.edu	37	chr6	33288181	33288181	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagaatccaaggaggcttcGggggtgtctgcagagtggga	9	7	17	8	1	1	2	0	0	1	2	3	4	2	4	2	5	1	2	2	5	2	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:33288181G>A	uc003oec.2	-	4	1431	c.1227C>T	c.(1225-1227)CCC>CCT	p.P409P	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Silent_p.P334P|DAXX_uc011dre.1_Silent_p.P421P|DAXX_uc003oed.2_Silent_p.P409P|DAXX_uc010juw.2_Silent_p.P334P	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	409	Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						AGGAGGCTTCGGGGGTGTCTG	0.542			Mis|F|N		Pancreatic neuroendocrine tumors								4	85					0	0	0	0	A	33288181	A	A	33288181	2	1	269	1	0	0	0	0	0	0	0	1	4260	1103	39	1		1	DAXX	6	33288181	Silent	SNP	G	TCGA-CV-7438-01A-21D-2129-08	118321	33288181	137826886	48	48810											
FILIP1	27145	broad.mit.edu	37	chr6	76024909	76024909	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccttttcttgttcaaggagCttttttaacctagaaaataa	12	16	6	7	0	2	1	1	0	1	1	2	2	2	2	2	1	2	2	2	1	6	9			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:76024909C>A	uc003pia.2	-	5	1012	c.639G>T	c.(637-639)AAG>AAT	p.K213N	FILIP1_uc003phy.1_Missense_Mutation_p.K213N|FILIP1_uc003phz.2_Missense_Mutation_p.K114N|FILIP1_uc010kbe.2_Missense_Mutation_p.K216N|FILIP1_uc003pib.1_5'UTR	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	213	Potential.									skin(3)|ovary(1)	4						GTTCAAGGAGCTTTTTTAACC	0.299													7	29					8.12818e-05	8.63269e-05	1	0	A	76024909	A	A	76024909	3	1	269	1	0	0	0	0	1	0	0	0	5926	796	28	4	3010	4	FILIP1	6	76024909	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	42736728	76024909	95090158	49	48811											
SOBP	55084	broad.mit.edu	37	chr6	107854757	107854757	+	Silent	SNP	C	T	T																															atgggaagtgaggtgaaaagCttctgcagcgagaagtgctt																										TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:107854757C>T	uc003prx.2	+	4	1020	c.516C>T	c.(514-516)AGC>AGT	p.S172S	SOBP_uc003prw.1_Silent_p.S172S	NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	172	FCS-type 1.						metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		AGGTGAAAAGCTTCTGCAGCG	0.512													31	115					0	0	0	0	T	107854757	T	T	107854757	2	4	269	1	0	0	0	0	0	0	0	1	14976	796	28	4		4	SOBP	6	107854757	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	31829848	107854757	63260310	50	48812	109	2									
SOBP	55084	broad.mit.edu	37	chr6	107854759	107854759	+	Missense_Mutation	SNP	T	G	G																															gggaagtgaggtgaaaagctTctgcagcgagaagtgctttg																										TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:107854759T>G	uc003prx.2	+	4	1022	c.518T>G	c.(517-519)TTC>TGC	p.F173C	SOBP_uc003prw.1_Missense_Mutation_p.F173C	NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	173	FCS-type 1.						metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GTGAAAAGCTTCTGCAGCGAG	0.517													29	115					0	0	0	0	G	107854759	G	G	107854759	3	3	269	1	0	0	0	0	1	0	0	0	14976	1783	62	5	532	5	SOBP	6	107854759	Missense_Mutation	SNP	T	TCGA-CV-7438-01A-21D-2129-08	2	107854759	63260308	51	48813	109	2									
LAMA4	3910	broad.mit.edu	37	chr6	112441515	112441515	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caggccatcattgtatttctCctggcttctaatcttcagtt	7	17	6	11	0	5	0	2	0	3	0	6	0	5	0	2	2	0	3	2	2	2	7			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:112441515C>T	uc003pvu.2	-	33	4945	c.4636G>A	c.(4636-4638)GAG>AAG	p.E1546K	LAMA4_uc003pvv.2_Missense_Mutation_p.E1539K|LAMA4_uc003pvt.2_Missense_Mutation_p.E1539K	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1546	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTGTATTTCTCCTGGCTTCTA	0.418													21	68					0	0	0	0	T	112441515	T	T	112441515	3	4	269	1	0	0	0	0	1	0	0	0	8648	864	30	2	863	2	LAMA4	6	112441515	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	4586756	112441515	58673552	52	48814											
IGF2R	3482	broad.mit.edu	37	chr6	160453983	160453983	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgtttttaggttcatcctAtatttcagatggaaaagaat	12	16	7	6	0	2	2	2	0	0	2	3	3	3	3	2	2	0	2	2	2	6	7			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:160453983A>G	uc003qta.2	+	9	1203	c.1055A>G	c.(1054-1056)TAT>TGT	p.Y352C		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	352	Lumenal (Potential).|3.				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GGTTCATCCTATATTTCAGAT	0.308													21	74					0	0	0	0	G	160453983	G	G	160453983	3	3	269	1	0	0	0	0	1	0	0	0	7615	449	16	5	1089	5	IGF2R	6	160453983	Missense_Mutation	SNP	A	TCGA-CV-7438-01A-21D-2129-08	48012468	160453983	10661084	53	48815											
UNC93A	54346	broad.mit.edu	37	chr6	167728857	167728857	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtatgggcttgtggagtgcGtggagtccaagaacccgatc	8	9	15	9	3	0	1	0	0	0	1	2	4	1	3	2	3	2	2	2	3	3	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:167728857G>A	uc003qvq.2	+	8	1466	c.1291G>A	c.(1291-1293)GTG>ATG	p.V431M	UNC93A_uc003qvr.2_Missense_Mutation_p.V389M	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	431						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TGTGGAGTGCGTGGAGTCCAA	0.547													21	306					0	0	0	0	A	167728857	A	A	167728857	3	1	269	1	0	0	0	0	1	0	0	0	17064	1145	40	1	1321	1	UNC93A	6	167728857	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	7274874	167728857	3386210	54	48816											
DLL1	28514	broad.mit.edu	37	chr6	170594698	170594698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccagccttcctggcagttgCactgccagggctgctggcag	5	8	13	15	0	0	0	0	0	0	0	1	0	1	0	4	3	4	6	4	3	0	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr6:170594698C>T	uc003qxm.2	-	6	1291	c.821G>A	c.(820-822)TGC>TAC	p.C274Y		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	274	Extracellular (Potential).|EGF-like 2.				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CTGGCAGTTGCACTGCCAGGG	0.627													23	45					0	0	0	0	T	170594698	T	T	170594698	3	4	269	1	0	0	0	0	1	0	0	0	4588	710	25	4	1374	4	DLL1	6	170594698	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	2865841	170594698	520369	55	48817											
SDK1	221935	broad.mit.edu	37	chr7	4116798	4116798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcctggtgacttcatccaCcatttcttctggagtgcccc	5	13	9	14	0	3	1	1	1	2	0	4	2	4	2	5	3	1	0	5	3	0	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:4116798C>T	uc003smx.2	+	21	3318	c.3179C>T	c.(3178-3180)ACC>ATC	p.T1060I	SDK1_uc010kso.2_Missense_Mutation_p.T336I	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1060	Fibronectin type-III 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACTTCATCCACCATTTCTTCT	0.562													6	27					0	0	0	0	T	4116798	T	T	4116798	3	4	269	1	0	0	0	0	1	0	0	0	14033	507	18	4	3261	4	SDK1	7	4116798	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08		4116798	155021865	56	48818											
EPO	2056	broad.mit.edu	37	chr7	100320671	100320671	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatcactgctgacactttccGcaaactcttccgagtctact	10	12	5	14	2	3	1	1	1	2	0	5	2	5	1	2	0	3	2	2	0	3	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:100320671G>A	uc003uwi.2	+	5	678	c.497G>A	c.(496-498)CGC>CAC	p.R166H	EPO_uc011kkc.1_Missense_Mutation_p.R165H	NM_000799	NP_000790	P01588	EPO_HUMAN	erythropoietin precursor	166					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	GACACTTTCCGCAAACTCTTC	0.572													28	134					0	0	0	0	A	100320671	A	A	100320671	3	1	269	1	0	0	0	0	1	0	0	0	5212	1087	38	1	515	1	EPO	7	100320671	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	96203873	100320671	58817992	57	48819											
RELN	5649	broad.mit.edu	37	chr7	103132413	103132413	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaaaccttgcatccttagTgtattccagcattacggaat	12	12	6	11	1	0	0	0	0	0	0	2	1	2	1	3	1	4	3	3	1	5	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:103132413T>C	uc003vca.2	-	58	9590	c.9430A>G	c.(9430-9432)ACT>GCT	p.T3144A	RELN_uc010liz.2_Missense_Mutation_p.T3144A	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3144	BNR 15.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GCATCCTTAGTGTATTCCAGC	0.303													7	16					0	0	0	0	C	103132413	C	C	103132413	3	2	269	1	0	0	0	0	1	0	0	0	13285	1696	59	5	984	5	RELN	7	103132413	Missense_Mutation	SNP	T	TCGA-CV-7438-01A-21D-2129-08	2811742	103132413	56006250	58	48820											
NUP205	23165	broad.mit.edu	37	chr7	135323426	135323426	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttaatagagatggaccgcGgcaaggtgagcttagttttt	11	12	13	5	2	0	2	0	1	0	1	0	4	0	3	1	3	1	4	1	3	4	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:135323426G>A	uc003vsw.2	+	38	5418	c.5387G>A	c.(5386-5388)CGG>CAG	p.R1796Q	NUP205_uc003vsx.2_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1796					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GATGGACCGCGGCAAGGTGAG	0.438													43	108					0	0	0	0	A	135323426	A	A	135323426	3	1	269	1	0	0	0	0	1	0	0	0	10813	1116	39	1	5537	1	NUP205	7	135323426	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	32191013	135323426	23815237	59	48821											
TAS2R40	259286	broad.mit.edu	37	chr7	142919983	142919983	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctttccacgtccaacatctTtgacacttacagttcctgga	9	14	5	13	1	2	1	0	1	2	0	5	2	5	2	3	1	2	1	3	1	2	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr7:142919983T>C	uc011ksx.1	+	1	812	c.812T>C	c.(811-813)TTT>TCT	p.F271S		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	271	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					TCCAACATCTTTGACACTTAC	0.473													33	86					0	0	0	0	C	142919983	C	C	142919983	3	2	269	1	0	0	0	0	1	0	0	0	15644	1841	64	5	814	5	TAS2R40	7	142919983	Missense_Mutation	SNP	T	TCGA-CV-7438-01A-21D-2129-08	7596557	142919983	16218680	60	48822											
TPD52	7163	broad.mit.edu	37	chr8	80954859	80954859	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatctctctacttgcctttAagttttcgaccttttcttca	6	20	3	12	1	5	0	2	0	3	0	7	1	5	0	2	0	2	1	2	0	2	9			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr8:80954859A>T	uc003ybr.1	-	5	873	c.551T>A	c.(550-552)TTA>TAA	p.L184*	TPD52_uc010lzr.2_RNA|TPD52_uc010lzs.1_RNA|TPD52_uc003ybs.1_Nonsense_Mutation_p.L167*|TPD52_uc003ybt.1_Nonsense_Mutation_p.L144*|TPD52_uc003ybq.1_RNA|TPD52_uc003ybu.1_RNA	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	184					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			ACTTGCCTTTAAGTTTTCGAC	0.308													22	67					0	0	0	0	T	80954859	T	T	80954859	4	4	269	1	0	0	0	0	0	1	0	0	16464	372	13	5	131	5	TPD52	8	80954859	Nonsense_Mutation	SNP	A	TCGA-CV-7438-01A-21D-2129-08		80954859	65409163	61	48823											
UBR5	51366	broad.mit.edu	37	chr8	103359220	103359220	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaccctcgatcccgtcctgTccgaataactcgagtctgcc	8	9	8	16	4	1	1	0	0	1	1	6	4	4	1	5	0	2	0	5	0	2	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr8:103359220T>A	uc003ykr.1	-	6	520	c.487A>T	c.(487-489)ACA>TCA	p.T163S	UBR5_uc003yks.1_Missense_Mutation_p.T163S	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	163					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TCCCGTCCTGTCCGAATAACT	0.567													24	197					0	0	0	0	A	103359220	A	A	103359220	3	1	269	1	0	0	0	0	1	0	0	0	16973	1667	58	5	8128	5	UBR5	8	103359220	Missense_Mutation	SNP	T	TCGA-CV-7438-01A-21D-2129-08	22404361	103359220	43004802	62	48824											
INSL4	3641	broad.mit.edu	37	chr9	5233770	5233770	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagggcagccatcattgAagaaaataatactttcccgc	14	9	8	10	1	1	3	1	2	0	1	2	3	2	3	2	1	2	1	2	1	6	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr9:5233770A>C	uc003ziy.2	+	2	418	c.313A>C	c.(313-315)AAG>CAG	p.K105Q		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	105					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		GCCATCATTGAAGAAAATAAT	0.393													4	66					0	0	0	0	C	5233770	C	C	5233770	3	2	269	1	0	0	0	0	1	0	0	0	7807	247	9	5	319	5	INSL4	9	5233770	Missense_Mutation	SNP	A	TCGA-CV-7438-01A-21D-2129-08		5233770	135979661	63	48825											
ZNF322B	387328	broad.mit.edu	37	chr9	99961655	99961655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacaagttttgcttgcattCaaggcactggtatatatgac	12	13	8	8	0	1	1	1	1	0	0	1	1	1	1	0	2	2	5	0	2	5	7			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr9:99961655C>T	uc004axd.1	-	1	256	c.139G>A	c.(139-141)GAA>AAA	p.E47K	uc004axb.2_5'Flank|ZNF322B_uc004axc.1_5'Flank|uc010msl.1_Intron	NM_199005	NP_945356			zinc finger protein 322B												0		Acute lymphoblastic leukemia(62;0.158)				TGCTTGCATTCAAGGCACTGG	0.338													11	303					0	0	0	0	T	99961655	T	T	99961655	3	4	269	1	0	0	0	0	1	0	0	0	17909	835	29	2	1073	2	ZNF322B	9	99961655	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	94727885	99961655	41251776	64	48826											
PAPPA	5069	broad.mit.edu	37	chr9	119093591	119093591	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctggtacccttgcaccatCagctacccatattcccagct	8	10	6	17	0	1	0	1	0	0	0	2	0	2	0	5	1	5	4	5	1	3	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr9:119093591C>T	uc004bjn.2	+	11	3597	c.3216C>T	c.(3214-3216)ATC>ATT	p.I1072I	PAPPA_uc011lxp.1_Silent_p.I767I|PAPPA_uc011lxq.1_Silent_p.I447I	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1072					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CTTGCACCATCAGCTACCCAT	0.473													26	65					0	0	0	0	T	119093591	T	T	119093591	2	4	269	1	0	0	0	0	0	0	0	1	11486	816	29	2		2	PAPPA	9	119093591	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	19131936	119093591	22119840	65	48827											
ADAMTS14	140766	broad.mit.edu	37	chr10	72511852	72511852	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagcctgcccaccccataggGatccagttcaccaaatacgg	11	6	8	16	1	1	0	1	0	0	0	2	1	2	1	6	2	3	1	6	2	3	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr10:72511852G>T	uc001jrh.2	+	18	2598	c.2598G>T	c.(2596-2598)GGG>GGT	p.G866G	ADAMTS14_uc001jrg.2_Silent_p.G869G	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	866	TSP type-1 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						ACCCCATAGGGATCCAGTTCA	0.662													8	20					0.00307968	0.00318302	1	0	T	72511852	T	T	72511852	2	4	269	1	0	0	0	0	0	0	0	1	259	1188	41	2		2	ADAMTS14	10	72511852	Silent	SNP	G	TCGA-CV-7438-01A-21D-2129-08		72511852	63022895	66	48828											
BLNK	29760	broad.mit.edu	37	chr10	97956812	97956812	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcttttccgaataagaaatGatccatcctgtttaattttt	12	17	5	7	1	0	2	0	1	0	1	3	3	3	2	3	0	1	2	3	0	4	7			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr10:97956812G>C	uc001kls.3	-	16	1281	c.1103C>G	c.(1102-1104)TCA>TGA	p.S368*	BLNK_uc001kme.3_Nonsense_Mutation_p.S263*|BLNK_uc001klt.3_Nonsense_Mutation_p.S259*|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Intron|BLNK_uc001klv.3_Intron|BLNK_uc001klw.3_Intron|BLNK_uc001klx.3_Nonsense_Mutation_p.S345*|BLNK_uc001kly.3_Intron|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Intron|BLNK_uc001kmb.3_Nonsense_Mutation_p.S164*|BLNK_uc001kmc.3_Intron|BLNK_uc001kmd.3_Nonsense_Mutation_p.S286*|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	368	SH2.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		AATAAGAAATGATCCATCCTG	0.269													5	36					0	0	0	0	C	97956812	C	C	97956812	4	2	269	1	0	0	0	0	0	1	0	0	1450	1294	45	2	275	2	BLNK	10	97956812	Nonsense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	25444960	97956812	37577935	67	48829											
JAKMIP3	282973	broad.mit.edu	37	chr10	133962932	133962932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaggagagggagaggaagtCacccgccatcagcttccacc	11	5	12	13	1	2	2	2	0	0	2	3	5	3	3	4	3	1	1	4	3	2	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr10:133962932C>T	uc001lkx.3	+	14	1865	c.1865C>T	c.(1864-1866)TCA>TTA	p.S622L	JAKMIP3_uc009yba.1_Missense_Mutation_p.S59L	NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GAGAGGAAGTCACCCGCCATC	0.647													6	12					0	0	0	0	T	133962932	T	T	133962932	3	4	269	1	0	0	0	0	1	0	0	0	7981	838	29	2	1919	2	JAKMIP3	10	133962932	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	36006120	133962932	1571815	68	48830											
ART1	417	broad.mit.edu	37	chr11	3680852	3680852	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacgacgagacctcttctctCaagagattcagctggacatg	11	9	9	12	2	4	2	2	0	2	2	5	6	4	3	1	1	1	1	1	1	1	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:3680852C>G	uc001lye.1	+	3	204	c.103C>G	c.(103-105)CAA>GAA	p.Q35E	ART1_uc009yeb.1_Missense_Mutation_p.Q35E	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	35					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	CCTCTTCTCTCAAGAGATTCA	0.602													12	38					0	0	0	0	G	3680852	G	G	3680852	3	3	269	1	0	0	0	0	1	0	0	0	999	827	29	2	109	2	ART1	11	3680852	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08		3680852	131325664	69	48831											
UBQLNL	143630	broad.mit.edu	37	chr11	5537578	5537578	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgcagtcttcactatcactcGagtggcacttgaagagatat	11	12	9	9	1	3	2	2	1	1	1	4	4	3	2	0	1	1	2	0	1	3	4	rs140401116		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:5537578G>C	uc001maz.3	-	1	379	c.94C>G	c.(94-96)CGA>GGA	p.R32G	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	32	Ubiquitin-like.									large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		ACTATCACTCGAGTGGCACTT	0.483													4	91					0	0	0	0	C	5537578	C	C	5537578	3	2	269	1	0	0	0	0	1	0	0	0	16968	1066	37	3	1337	3	UBQLNL	11	5537578	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	1856726	5537578	129468938	70	48832											
RIC3	79608	broad.mit.edu	37	chr11	8158952	8158953	+	Frame_Shift_Ins	INS	-	T	T																															attaggtcccactctgttgaINSttaatttttccatggctgct																										TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:8158952_8158953insT	uc001mgd.2	-	4	547_548	c.493_494insA	c.(493-495)ATCfs	p.I165fs	RIC3_uc001mgb.2_5'UTR|RIC3_uc001mgc.2_Frame_Shift_Ins_p.I165fs|RIC3_uc001mge.2_Intron|RIC3_uc010rbl.1_Frame_Shift_Ins_p.I115fs|RIC3_uc010rbm.1_Frame_Shift_Ins_p.I165fs|RIC3_uc009yfm.2_Intron|RIC3_uc009yfn.2_Intron	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	165	Potential.|Cytoplasmic (Potential).			I -> F (in Ref. 6; AAH22455).		endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		CACTCTGTTGATTAATTTTTCC	0.342													---	---	---								T	8158953	T	T	8158952	7	5	269	1	0	1	1	0	0	0	0	0	13419	333	12	0	624	0	RIC3	11	8158952	Frame_Shift_Ins	INS	-	TCGA-CV-7438-01A-21D-2129-08	2621374	8158952	126847564	71	48833											
KIF18A	81930	broad.mit.edu	37	chr11	28084055	28084055	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtgacaatgaagatctttCttgagttcctagggcaaaca	12	12	10	7	0	2	4	0	3	2	1	3	4	3	4	1	2	1	2	1	2	4	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:28084055C>A	uc001msc.2	-	12	1781	c.1599G>T	c.(1597-1599)AAG>AAT	p.K533N		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	533					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						GAAGATCTTTCTTGAGTTCCT	0.323													22	49					4.4004e-07	4.77227e-07	1	0	A	28084055	A	A	28084055	3	1	269	1	0	0	0	0	1	0	0	0	8319	912	32	2	1121	2	KIF18A	11	28084055	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	19925103	28084055	106922461	72	48834											
SCYL1	57410	broad.mit.edu	37	chr11	65304114	65304114	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagccgcagctagctgggCaggctgggccgtgaccgggg	6	4	20	11	3	0	1	0	1	0	0	0	2	0	2	3	6	3	5	3	6	1	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:65304114C>T	uc001oea.1	+	13	1786	c.1709C>T	c.(1708-1710)GCA>GTA	p.A570V	SCYL1_uc009yqk.2_Missense_Mutation_p.A570V|SCYL1_uc001oeb.1_Missense_Mutation_p.A570V|SCYL1_uc001oec.1_Missense_Mutation_p.A570V|SCYL1_uc001oed.1_Missense_Mutation_p.A427V|SCYL1_uc001oee.1_Missense_Mutation_p.A214V	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	570					regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						GCTAGCTGGGCAGGCTGGGCC	0.627													12	67					0	0	0	0	T	65304114	T	T	65304114	3	4	269	1	0	0	0	0	1	0	0	0	14012	710	25	4	1759	4	SCYL1	11	65304114	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	37220059	65304114	69702402	73	48835											
SYT12	91683	broad.mit.edu	37	chr11	66811318	66811318	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggctctatttacaggaccaGaacaaggtaagtgacttgcc	12	10	10	9	0	1	2	0	1	1	1	1	3	1	3	2	3	3	2	2	3	5	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:66811318G>A	uc009yrl.2	+	5	1061	c.831G>A	c.(829-831)CAG>CAA	p.Q277Q	SYT12_uc001oju.2_Silent_p.Q277Q	NM_177963	NP_808878	Q8IV01	SYT12_HUMAN	synaptotagmin XII	277	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane				ovary(1)	1						TACAGGACCAGAACAAGGTAA	0.552													14	49					0	0	0	0	A	66811318	A	A	66811318	2	1	269	1	0	0	0	0	0	0	0	1	15534	933	33	2		2	SYT12	11	66811318	Silent	SNP	G	TCGA-CV-7438-01A-21D-2129-08	1507204	66811318	68195198	74	48836											
ANO1	55107	broad.mit.edu	37	chr11	70007358	70007358	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaactcctccccctccgtgcGgtccaacatccgggtcacag	7	7	9	18	3	1	0	1	0	0	0	6	1	6	0	6	2	3	0	6	2	2	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:70007358G>A	uc001opj.2	+	17	1975	c.1670G>A	c.(1669-1671)CGG>CAG	p.R557Q	ANO1_uc001opk.1_Missense_Mutation_p.R499Q|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.R266Q	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	557	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CCCTCCGTGCGGTCCAACATC	0.592													23	69					0	0	0	0	A	70007358	A	A	70007358	3	1	269	1	0	0	0	0	1	0	0	0	695	1116	39	1	1736	1	ANO1	11	70007358	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	3196040	70007358	64999158	75	48837											
FZD4	8322	broad.mit.edu	37	chr11	86662820	86662820	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtcctgctgccaaaaaccaAgtgagtgtcagaataaccca	15	7	8	11	0	1	2	1	1	0	1	2	2	2	2	4	0	4	1	4	0	5	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr11:86662820A>G	uc001pce.2	-	2	1284	c.978T>C	c.(976-978)ACT>ACC	p.T326T	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	326	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCAAAAACCAAGTGAGTGTCA	0.453													4	22					0	0	0	0	G	86662820	G	G	86662820	2	3	269	1	0	0	0	0	0	0	0	1	6166	59	3	5		5	FZD4	11	86662820	Silent	SNP	A	TCGA-CV-7438-01A-21D-2129-08	16655462	86662820	48343696	76	48838											
WNK1	65125	broad.mit.edu	37	chr12	989016	989016	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcatctgctacaacagctgCgatcccgggggtatcaactg	9	10	10	12	2	3	0	2	0	1	0	4	1	4	0	1	2	6	3	1	2	4	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:989016C>T	uc001qio.3	+	11	3158	c.2651C>T	c.(2650-2652)GCG>GTG	p.A884V	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	884					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ACAACAGCTGCGATCCCGGGG	0.547													25	95					0	0	0	0	T	989016	T	T	989016	3	4	269	1	0	0	0	0	1	0	0	0	17445	768	27	1	4195	1	WNK1	12	989016	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08		989016	132862879	77	48839											
FKBP4	2288	broad.mit.edu	37	chr12	2909727	2909727	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaggccttctctgctgccaTtgaaagctgtaacaaggtga	11	10	10	10	0	1	2	0	2	1	0	2	2	1	2	2	2	4	3	2	2	3	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:2909727T>C	uc001qkz.2	+	8	1214	c.1016T>C	c.(1015-1017)ATT>ACT	p.I339T		NM_002014	NP_002005	Q02790	FKBP4_HUMAN	FK506 binding protein 52	339	TPR 2.|Interaction with tubulin (By similarity).				negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging				0			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	TCTGCTGCCATTGAAAGCTGT	0.532													9	39					0	0	0	0	C	2909727	C	C	2909727	3	2	269	1	0	0	0	0	1	0	0	0	5942	1493	52	5	1046	5	FKBP4	12	2909727	Missense_Mutation	SNP	T	TCGA-CV-7438-01A-21D-2129-08	1920711	2909727	130942168	78	48840											
SPSB2	84727	broad.mit.edu	37	chr12	6981568	6981569	+	Frame_Shift_Del	DEL	TC	-	-																															atgtccagaaccaccagcagTctctctggcacctccagctg																										TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:6981568_6981569delTC	uc001qrl.2	-	2	653_654	c.497_498delGA	c.(496-498)AGAfs	p.R166fs	SPSB2_uc001qrm.2_Frame_Shift_Del_p.R166fs|SPSB2_uc010sfp.1_Frame_Shift_Del_p.R166fs|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	166	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1						CCACCAGCAGTCTCTCTGGCAC	0.644											OREG0021639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	6981569	-	-	6981568	7	5	269	1	0	1	0	1	0	0	0	0	15179	1664	58	0	301	0	SPSB2	12	6981568	Frame_Shift_Del	DEL	TC	TCGA-CV-7438-01A-21D-2129-08	4071841	6981568	126870327	79	48841											
PDE3A	5139	broad.mit.edu	37	chr12	20801805	20801805	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaagaaacactttgacttcGtagccaaatttaatggcaag	15	11	8	7	1	0	3	0	2	0	1	1	3	0	3	1	1	2	2	1	1	6	5	rs148455779		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:20801805G>A	uc001reh.1	+	13	2771	c.2749G>A	c.(2749-2751)GTA>ATA	p.V917I		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	917	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTTTGACTTCGTAGCCAAATT	0.269													18	60					0	0	0	0	A	20801805	A	A	20801805	3	1	269	1	0	0	0	0	1	0	0	0	11691	1145	40	1	2799	1	PDE3A	12	20801805	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	13820237	20801805	113050090	80	48842											
ESPL1	9700	broad.mit.edu	37	chr12	53680134	53680134	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacccaagctctccaagcttCcctgaatcataaaacacccc	13	7	3	18	0	2	1	1	1	1	0	4	1	3	1	5	0	3	2	5	0	5	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:53680134C>T	uc001sck.2	+	18	3705	c.3614C>T	c.(3613-3615)TCC>TTC	p.S1205F	ESPL1_uc001scj.2_Missense_Mutation_p.S880F|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1205					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CTCCAAGCTTCCCTGAATCAT	0.587													28	99					0	0	0	0	T	53680134	T	T	53680134	3	4	269	1	0	0	0	0	1	0	0	0	5277	855	30	2	3680	2	ESPL1	12	53680134	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	32878329	53680134	80171761	81	48843											
LRP1	4035	broad.mit.edu	37	chr12	57571375	57571375	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atcctttggattgacgccagGtcagcaccctctgtgccctg	6	11	10	14	1	2	1	1	1	1	0	3	2	3	2	4	2	2	1	4	2	0	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:57571375G>T	uc001snd.2	+	26	4827	c.4361_splice	c.e26+1	p.R1454_splice		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1						aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TTGACGCCAGGTCAGCACCCT	0.652													9	19					2.74318e-10	3.08357e-10	1	0	T	57571375	T	T	57571375	5	4	269	1	0	0	0	0	0	0	1	0	9001	1275	44	4	4464	4	LRP1	12	57571375	Splice_Site	SNP	G	TCGA-CV-7438-01A-21D-2129-08	3891241	57571375	76280520	82	48844											
LRIG3	121227	broad.mit.edu	37	chr12	59272720	59272720	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gataaagaacacgtcatcctCgggcatcacatgcatgcgtc	12	8	9	12	3	2	1	2	0	0	1	5	2	3	1	1	1	3	2	1	1	3	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:59272720C>A	uc001sqr.2	-	14	2215	c.1969G>T	c.(1969-1971)GAG>TAG	p.E657*	LRIG3_uc009zqh.2_Nonsense_Mutation_p.E597*|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	657	Ig-like C2-type 2.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			ACGTCATCCTCGGGCATCACA	0.552													9	95					0.000274275	0.000287336	1	0	A	59272720	A	A	59272720	4	1	269	1	0	0	0	0	0	1	0	0	8996	893	31	3	1414	3	LRIG3	12	59272720	Nonsense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	1701345	59272720	74579175	83	48845											
PPFIA2	8499	broad.mit.edu	37	chr12	81762943	81762943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accctctaaatgtctcatacGttcttcaatatttccatgtc	10	16	3	12	1	4	0	2	0	3	0	7	0	5	0	2	0	1	1	2	0	5	6			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr12:81762943G>A	uc001szo.1	-	12	1458	c.1297C>T	c.(1297-1299)CGT>TGT	p.R433C	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	359										ovary(3)|lung(2)|pancreas(1)	6						TGTCTCATACGTTCTTCAATA	0.318													6	17					0	0	0	0	A	81762943	A	A	81762943	3	1	269	1	0	0	0	0	1	0	0	0	12365	1145	40	1	2560	1	PPFIA2	12	81762943	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	22490223	81762943	52088952	84	48846											
XPO4	64328	broad.mit.edu	37	chr13	21375044	21375044	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaaccaaacaatatctttgcCcatctggggacttagtagat	14	11	7	9	0	2	1	0	0	2	1	2	2	2	2	2	2	3	1	2	2	6	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr13:21375044C>A	uc001unq.3	-	14	1939	c.1903G>T	c.(1903-1905)GGC>TGC	p.G635C		NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	635					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		ATATCTTTGCCCATCTGGGGA	0.393													35	142					4.3181e-19	4.96259e-19	1	0	A	21375044	A	A	21375044	3	1	269	1	0	0	0	0	1	0	0	0	17514	623	22	4	1592	4	XPO4	13	21375044	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08		21375044	93794834	85	48847											
RXFP2	122042	broad.mit.edu	37	chr13	32339254	32339254	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacttaaagtctgtgccgAtgatttctaacaatgtgaca	12	13	9	7	1	2	3	0	3	2	0	2	4	2	3	1	0	2	0	1	0	4	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr13:32339254A>C	uc001utt.2	+	4	471	c.400A>C	c.(400-402)ATG>CTG	p.M134L	RXFP2_uc010aba.2_Missense_Mutation_p.M117L	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	134	Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		GTCTGTGCCGATGATTTCTAA	0.348													6	73					0	0	0	0	C	32339254	C	C	32339254	3	2	269	1	0	0	0	0	1	0	0	0	13825	333	12	5	414	5	RXFP2	13	32339254	Missense_Mutation	SNP	A	TCGA-CV-7438-01A-21D-2129-08	10964210	32339254	82830624	86	48848											
MDGA2	161357	broad.mit.edu	37	chr14	47530570	47530570	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatcaatgatgtccaagttTgttgttcccggagagacatc	12	12	9	8	1	1	2	1	1	0	1	4	4	3	3	2	1	0	3	2	1	3	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr14:47530570T>C	uc001wwj.3	-	7	1396	c.1200A>G	c.(1198-1200)ACA>ACG	p.T400T	MDGA2_uc001wwi.3_Silent_p.T171T|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	400	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TGTCCAAGTTTGTTGTTCCCG	0.403													8	182					0	0	0	0	C	47530570	C	C	47530570	2	2	269	1	0	0	0	0	0	0	0	1	9460	1799	63	5		5	MDGA2	14	47530570	Silent	SNP	T	TCGA-CV-7438-01A-21D-2129-08		47530570	59818970	87	48849											
PLEKHH1	57475	broad.mit.edu	37	chr14	68050595	68050596	+	Silent	DNP	GC	AT	AT																															catggggcccccgctgaacaGctgaggtaggtaggctacaa																										TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr14:68050595_68050596GC>AT	uc001xjl.1	+	25	3706_3707	c.3564_3565GC>AT	c.(3562-3567)CAGCTG>CAATTG	p.1188_1189QL>QL	PLEKHH1_uc010tsw.1_Silent_p.756_757QL>QL|PLEKHH1_uc001xjn.1_Silent_p.703_704QL>QL|PLEKHH1_uc010tsx.1_Silent_p.53_54QL>QL|PLEKHH1_uc001xjo.1_Silent_p.53_54QL>QL|PLEKHH1_uc001xjp.1_Silent_p.53_54QL>QL	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	1188_1189	FERM.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CCGCTGAACAGCTGAGGTAGGT	0.584											OREG0022749	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	29					0	0	0	0	AT	68050596	AT	AT	68050595	2	1	269	1	0	0	0	0	0	0	0	1	12131	962	34	4		4	PLEKHH1	14	68050595	Silent	DNP	GC	TCGA-CV-7438-01A-21D-2129-08	20520025	68050595	39298945	88	48850											
ZFP36L1	677	broad.mit.edu	37	chr14	69257020	69257020	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcggtctcggaagcggctgtCtcgcgagctcagagcggggg	5	6	19	11	6	3	1	1	0	2	1	5	3	3	2	0	5	3	2	0	5	1	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr14:69257020C>G	uc001xkh.1	-	2	377	c.247G>C	c.(247-249)GAC>CAC	p.D83H	ZFP36L1_uc001xki.1_Missense_Mutation_p.D83H	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	83					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AAGCGGCTGTCTCGCGAGCTC	0.682											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	31					0	0	0	0	G	69257020	G	G	69257020	3	3	269	1	0	0	0	0	1	0	0	0	17713	913	32	2	773	2	ZFP36L1	14	69257020	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	1206425	69257020	38092520	89	48851											
ADSSL1	122622	broad.mit.edu	37	chr14	105201381	105201381	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcaacaacgccggccacacgGtggtggtggatgggaaagag	11	4	17	9	3	0	1	0	0	0	1	0	3	0	3	2	6	2	1	2	6	3	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr14:105201381G>T	uc001ypd.2	+	2	291	c.217G>T	c.(217-219)GTG>TTG	p.V73L	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Missense_Mutation_p.V116L|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	73					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CGGCCACACGGTGGTGGTGGA	0.627													4	21					0.00909568	0.00933823	1	0	T	105201381	T	T	105201381	3	4	269	1	0	0	0	0	1	0	0	0	348	1261	44	4	548	4	ADSSL1	14	105201381	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	35944361	105201381	2148159	90	48852											
DUOX1	53905	broad.mit.edu	37	chr15	45428812	45428812	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaccatggtgccccctggCgtctacatgaggtgagggag	7	8	14	12	1	1	2	0	2	1	0	2	3	2	3	4	4	2	0	4	4	1	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr15:45428812C>T	uc001zus.1	+	10	1357	c.1011C>T	c.(1009-1011)GGC>GGT	p.G337G	DUOX1_uc001zut.1_Silent_p.G337G|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	337	Peroxidase-like; mediates peroxidase activity.|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TGCCCCCTGGCGTCTACATGA	0.592													11	52					0	0	0	0	T	45428812	T	T	45428812	2	4	269	1	0	0	0	0	0	0	0	1	4822	755	27	1		1	DUOX1	15	45428812	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08		45428812	57102580	91	48853											
TRPM7	54822	broad.mit.edu	37	chr15	50867173	50867173	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggatatcatgttctgaccagGtacactgtactttgacagct	10	13	9	9	0	2	2	1	2	1	0	2	3	2	3	1	2	3	4	1	2	3	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr15:50867173G>A	uc001zyt.3	-	34	5159	c.4895C>T	c.(4894-4896)ACC>ATC	p.T1632I	TRPM7_uc001zyr.2_Missense_Mutation_p.T69I	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	1632	Cytoplasmic (Potential).|Alpha-type protein kinase.				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TTCTGACCAGGTACACTGTAC	0.388													33	115					0	0	0	0	A	50867173	A	A	50867173	3	1	269	1	0	0	0	0	1	0	0	0	16658	1261	44	4	726	4	TRPM7	15	50867173	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	5438361	50867173	51664219	92	48854											
CYP1A2	1544	broad.mit.edu	37	chr15	75042710	75042710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttcggacagcacttccctGagagtagcgatgagatgctc	9	9	12	11	2	0	2	0	2	0	2	3	6	1	3	1	1	3	4	1	1	1	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr15:75042710G>A	uc002ayr.1	+	2	695	c.631G>A	c.(631-633)GAG>AAG	p.E211K		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	211					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	GCACTTCCCTGAGAGTAGCGA	0.577													26	173					0	0	0	0	A	75042710	A	A	75042710	3	1	269	1	0	0	0	0	1	0	0	0	4167	1291	45	2	633	2	CYP1A2	15	75042710	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	24175537	75042710	27488682	93	48855											
PDXDC1	23042	broad.mit.edu	37	chr16	15110041	15110041	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agattgaaagaactctgtgaGcagtatggcatatggcttca	13	11	11	6	0	2	4	1	2	1	2	2	4	2	4	0	2	2	4	0	2	4	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr16:15110041G>C	uc002dda.3	+	9	1007	c.783G>C	c.(781-783)GAG>GAC	p.E261D	PDXDC1_uc010uzl.1_Missense_Mutation_p.E246D|PDXDC1_uc010uzm.1_Missense_Mutation_p.E170D|PDXDC1_uc002dcz.2_Missense_Mutation_p.E238D|PDXDC1_uc002ddb.3_Missense_Mutation_p.E234D|PDXDC1_uc010uzn.1_Missense_Mutation_p.E233D|PDXDC1_uc002ddc.2_Missense_Mutation_p.E261D	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	261					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	AACTCTGTGAGCAGTATGGCA	0.502													8	55					0	0	0	0	C	15110041	C	C	15110041	3	2	269	1	0	0	0	0	1	0	0	0	11750	962	34	4	817	4	PDXDC1	16	15110041	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08		15110041	75244712	94	48856											
HPR	3250	broad.mit.edu	37	chr16	72110502	72110502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctaccaccaggtagatattgGgctcatcaaactcaaacaga	15	8	7	11	0	3	2	3	0	0	2	3	2	3	2	2	2	3	2	2	2	5	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr16:72110502G>A	uc002fby.2	+	5	599	c.569G>A	c.(568-570)GGG>GAG	p.G190E	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	190	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				GTAGATATTGGGCTCATCAAA	0.448													15	75					0	0	0	0	A	72110502	A	A	72110502	3	1	269	1	0	0	0	0	1	0	0	0	7376	1232	43	4	587	4	HPR	16	72110502	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	57000461	72110502	18244251	95	48857											
KCNG4	93107	broad.mit.edu	37	chr16	84270496	84270496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggttcatgcacaggccccagCgcgaggagtgcgaggcgggg	7	4	19	11	4	1	0	1	0	0	0	1	3	1	1	2	6	3	2	2	6	0	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr16:84270496C>T	uc010voc.1	-	2	717	c.596G>A	c.(595-597)CGC>CAC	p.R199H	KCNG4_uc002fhu.1_Missense_Mutation_p.R199H	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	199						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						CAGGCCCCAGCGCGAGGAGTG	0.677													15	36					0	0	0	0	T	84270496	T	T	84270496	3	4	269	1	0	0	0	0	1	0	0	0	8069	768	27	1	969	1	KCNG4	16	84270496	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	12159994	84270496	6084257	96	48858											
TP53	7157	broad.mit.edu	37	chr17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcaccaccacactatgtcGaaaagtgtttctgtcatcca	11	10	8	12	1	2	0	1	0	1	0	4	1	3	0	3	1	0	2	3	1	3	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	24					0	0	0	0	A	7578212	A	A	7578212	4	1	269	1	0	0	0	0	0	1	0	0	16448	1066	37	1	657	1	TP53	17	7578212	Nonsense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08		7578212	73616998	97	48859											
MYH3	4621	broad.mit.edu	37	chr17	10542363	10542363	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtggttgaagggcatacttCttgagcctttcgtccagctg	7	13	12	9	1	1	2	0	2	1	0	3	2	2	2	2	2	3	3	2	2	2	5			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:10542363C>G	uc002gmq.1	-	24	3323	c.3246G>C	c.(3244-3246)AAG>AAC	p.K1082N		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1082	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.K1082N(1)		ovary(4)|central_nervous_system(2)|pancreas(1)	7						GGGCATACTTCTTGAGCCTTT	0.398													22	71					0	0	0	0	G	10542363	G	G	10542363	3	3	269	1	0	0	0	0	1	0	0	0	10089	912	32	2	2644	2	MYH3	17	10542363	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	2964151	10542363	70652847	98	48860											
KRT14	3861	broad.mit.edu	37	chr17	39740142	39740142	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ccatctccacattgacatctCcacccacctggcctctcagg	8	9	5	19	0	3	1	1	1	3	0	6	1	3	1	6	2	0	0	6	2	0	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:39740142C>G	uc002hxf.1	-	4	858	c.797G>C	c.(796-798)GGA>GCA	p.G266A	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Missense_Mutation_p.G266A	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	266	Rod.|Linker 12.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				ATTGACATCTCCACCCACCTG	0.577													9	108					0	0	0	0	G	39740142	G	G	39740142	3	3	269	1	0	0	0	0	1	0	0	0	8490	855	30	2	641	2	KRT14	17	39740142	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	29197779	39740142	41455068	99	48861											
SPOP	8405	broad.mit.edu	37	chr17	47679366	47679366	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctttaagcgctccagggCatactgtaaaacacaagcac	14	7	8	12	1	0	0	0	0	0	0	1	1	1	0	2	1	4	4	2	1	5	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:47679366C>A	uc010dbk.2	-	10	1473	c.841G>T	c.(841-843)GCC>TCC	p.A281S	SPOP_uc002ipb.2_Missense_Mutation_p.A281S|SPOP_uc002ipc.2_Missense_Mutation_p.A281S|SPOP_uc002ipd.2_Missense_Mutation_p.A281S|SPOP_uc002ipe.2_Missense_Mutation_p.A281S|SPOP_uc002ipf.2_Missense_Mutation_p.A281S|SPOP_uc002ipg.2_Missense_Mutation_p.A281S	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein	281	BTB.				mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						CGCTCCAGGGCATACTGTAAA	0.493										Prostate(2;0.17)			42	45					6.48837e-15	7.34712e-15	1	0	A	47679366	A	A	47679366	3	1	269	1	0	0	0	0	1	0	0	0	15150	710	25	4	291	4	SPOP	17	47679366	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	7939224	47679366	33515844	100	48862											
SGCA	6442	broad.mit.edu	37	chr17	48245850	48245850	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggggggactctgggagccCggagagcttcagctgctcaa	7	8	16	10	1	3	1	2	0	1	1	3	4	3	3	1	5	4	3	1	5	1	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr17:48245850C>T	uc002iqi.2	+	5	537	c.501C>T	c.(499-501)CCC>CCT	p.P167P	SGCA_uc010wmh.1_Silent_p.P65P|SGCA_uc002iqj.2_Silent_p.P167P|SGCA_uc010wmi.1_RNA|uc010dbn.1_5'Flank	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	167	Extracellular (Potential).				muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						TCTGGGAGCCCGGAGAGCTTC	0.642													5	1					0	0	0	0	T	48245850	T	T	48245850	2	4	269	1	0	0	0	0	0	0	0	1	14264	639	23	1		1	SGCA	17	48245850	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	566484	48245850	32949360	101	48863											
GNAL	2774	broad.mit.edu	37	chr18	11872355	11872355	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagggaaatcaaaaattgaaGactatttcccagaatatgca	18	9	7	7	0	1	3	1	1	0	2	2	4	2	4	1	1	1	1	1	1	7	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr18:11872355G>C	uc010dkz.2	+	11	1135	c.889G>C	c.(889-891)GAC>CAC	p.D297H	GNAL_uc002kqc.2_Missense_Mutation_p.D374H|GNAL_uc002kqd.2_Missense_Mutation_p.D297H|GNAL_uc010wzt.1_Missense_Mutation_p.D90H	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	297					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						AAAAATTGAAGACTATTTCCC	0.333													24	71					0	0	0	0	C	11872355	C	C	11872355	3	2	269	1	0	0	0	0	1	0	0	0	6544	942	33	2	1307	2	GNAL	18	11872355	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08		11872355	66204893	102	48864											
TRAPPC5	126003	broad.mit.edu	37	chr19	7747352	7747352	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctggatgcgctggtggcGcgcgaaaagggtgcccggcg	5	6	20	10	6	0	0	0	0	0	0	0	2	0	1	1	5	3	2	1	5	2	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:7747352G>A	uc002mhi.1	+	2	283	c.213G>A	c.(211-213)GCG>GCA	p.A71A	TRAPPC5_uc002mhj.1_Silent_p.A71A|TRAPPC5_uc002mhk.1_Silent_p.A71A	NM_001042462	NP_001035927	Q8IUR0	TPPC5_HUMAN	trafficking protein particle complex 5	71					vesicle-mediated transport	endoplasmic reticulum	guanylate cyclase activity|heme binding				0						CGCTGGTGGCGCGCGAAAAGG	0.711													10	27					0	0	0	0	A	7747352	A	A	7747352	2	1	269	1	0	0	0	0	0	0	0	1	16529	1074	38	1		1	TRAPPC5	19	7747352	Silent	SNP	G	TCGA-CV-7438-01A-21D-2129-08		7747352	51381631	103	48865											
LPPR2	64748	broad.mit.edu	37	chr19	11470246	11470246	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgatcctgcttgcttaccgCctggagttcacggacacctt	6	12	10	13	2	1	1	1	1	0	0	2	3	2	3	4	2	3	3	4	2	1	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:11470246C>G	uc002mre.1	+	4	442	c.105C>G	c.(103-105)CGC>CGG	p.R35R	LPPR2_uc002mrf.1_Intron|LPPR2_uc010dxy.1_5'Flank	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	35						integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						TTGCTTACCGCCTGGAGTTCA	0.622													9	49					0	0	0	0	G	11470246	G	G	11470246	2	3	269	1	0	0	0	0	0	0	0	1	8975	726	26	4		4	LPPR2	19	11470246	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	3722894	11470246	47658737	104	48866											
OR10H1	26539	broad.mit.edu	37	chr19	15918404	15918404	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgaccaagccaccagcccaGgagcagcccaccaggcaggc	12	1	11	17	0	0	1	0	1	0	0	0	2	0	2	6	3	4	2	6	3	1	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:15918404G>A	uc002nbq.2	-	1	533	c.444C>T	c.(442-444)TCC>TCT	p.S148S		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACCAGCCCAGGAGCAGCCCA	0.632													4	82					0	0	0	0	A	15918404	A	A	15918404	2	1	269	1	0	0	0	0	0	0	0	1	10959	987	35	4		4	OR10H1	19	15918404	Silent	SNP	G	TCGA-CV-7438-01A-21D-2129-08	4448158	15918404	43210579	105	48867											
SIN3B	23309	broad.mit.edu	37	chr19	16974605	16974605	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgtgaggacgagcgcttcGaggtgtgtgtgctgctgtgg	4	11	19	7	3	0	1	0	1	0	0	1	4	0	2	0	3	3	4	0	3	0	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:16974605G>A	uc002ney.1	+	11	1491	c.1477G>A	c.(1477-1479)GAG>AAG	p.E493K	SIN3B_uc002nez.1_Missense_Mutation_p.E461K|SIN3B_uc010xpi.1_Missense_Mutation_p.E51K	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	493	Interaction with SDS3 and HDAC1 (By similarity).|Interaction with NCOR1 (By similarity).				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						CGAGCGCTTCGAGGTGTGTGT	0.612													12	41					0	0	0	0	A	16974605	A	A	16974605	3	1	269	1	0	0	0	0	1	0	0	0	14391	1059	37	1	1519	1	SIN3B	19	16974605	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	1056201	16974605	42154378	106	48868											
ZNF100	163227	broad.mit.edu	37	chr19	21909496	21909496	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacatttttcacatttgtaGggtttctctccagtatgagt	8	17	7	9	0	2	1	1	1	1	0	4	1	3	1	2	1	0	3	2	1	2	6			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:21909496G>C	uc002nqi.2	-	5	1817	c.1618C>G	c.(1618-1620)CTA>GTA	p.L540V	ZNF100_uc002nqh.2_Missense_Mutation_p.L476V	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	540					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACATTTGTAGGGTTTCTCTC	0.363													3	44					0	0	0	0	C	21909496	C	C	21909496	3	2	269	1	0	0	0	0	1	0	0	0	17780	991	35	4	14	4	ZNF100	19	21909496	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	4934891	21909496	37219487	107	48869											
ZNF208	7757	broad.mit.edu	37	chr19	22157388	22157388	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttatgaaagacatttgcatAtttgccacgttgaaatactt	13	16	6	6	1	0	3	0	2	0	1	0	3	0	3	1	0	3	2	1	0	5	8			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:22157388A>G	uc002nqp.2	-	4	597	c.448T>C	c.(448-450)TAT>CAT	p.Y150H	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATTTGCATATTTGCCACGT	0.328													21	81					0	0	0	0	G	22157388	G	G	22157388	3	3	269	1	0	0	0	0	1	0	0	0	17833	449	16	5	3398	5	ZNF208	19	22157388	Missense_Mutation	SNP	A	TCGA-CV-7438-01A-21D-2129-08	247892	22157388	36971595	108	48870											
MAG	4099	broad.mit.edu	37	chr19	35791165	35791165	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgacctggatgcgggaCgggacagtcctccgggaggc	6	6	17	12	3	0	1	0	1	0	0	2	5	2	5	3	5	2	1	3	5	0	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:35791165C>T	uc002nyy.1	+	6	977	c.828C>T	c.(826-828)GAC>GAT	p.D276D	MAG_uc002nyx.1_Silent_p.D276D|MAG_uc010eds.1_Silent_p.D251D|MAG_uc002nyz.1_Silent_p.D276D	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	276	Ig-like C2-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GGATGCGGGACGGGACAGTCC	0.687													4	14					0	0	0	0	T	35791165	T	T	35791165	2	4	269	1	0	0	0	0	0	0	0	1	9213	535	19	1		1	MAG	19	35791165	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	13633777	35791165	23337818	109	48871											
HIPK4	147746	broad.mit.edu	37	chr19	40887043	40887043	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaatctggtccaacgacttGagcatatacttgcggcgctc	9	11	9	12	3	2	1	1	1	1	0	4	2	3	1	1	2	4	2	1	2	4	4			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:40887043G>C	uc002onp.2	-	3	1140	c.855C>G	c.(853-855)CTC>CTG	p.L285L		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	285	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			CCAACGACTTGAGCATATACT	0.632													12	34					0	0	0	0	C	40887043	C	C	40887043	2	2	269	1	0	0	0	0	0	0	0	1	7158	1277	45	2		2	HIPK4	19	40887043	Silent	SNP	G	TCGA-CV-7438-01A-21D-2129-08	5095878	40887043	18241940	110	48872											
B3GNT8	374907	broad.mit.edu	37	chr19	41932174	41932174	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggagctggactgccccaCgtctctctcacggcctgtcg	4	9	11	17	3	2	0	1	0	2	0	5	2	2	2	4	3	2	1	4	3	0	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr19:41932174C>T	uc002oqs.2	-	3	964	c.510G>A	c.(508-510)ACG>ACA	p.T170T	CYP2F1_uc010xvw.1_Intron|B3GNT8_uc002oqt.1_Intron	NM_198540	NP_940942	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal	170	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity				0						GACTGCCCCACGTCTCTCTCA	0.627													22	76					0	0	0	0	T	41932174	T	T	41932174	2	4	269	1	0	0	0	0	0	0	0	1	1265	523	19	1		1	B3GNT8	19	41932174	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	1045131	41932174	17196809	111	48873											
JAG1	182	broad.mit.edu	37	chr20	10630209	10630209	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catccagccgggaagacagtCgcagtagtagctggcaatga	12	6	13	10	2	0	2	0	1	0	1	2	3	1	3	2	2	2	5	2	2	4	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:10630209C>T	uc002wnw.2	-	10	1825	c.1309G>A	c.(1309-1311)GAC>AAC	p.D437N	JAG1_uc010gcd.1_5'UTR	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	437	EGF-like 6; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GGAAGACAGTCGCAGTAGTAG	0.458									Alagille_Syndrome				9	39					0	0	0	0	T	10630209	T	T	10630209	3	4	269	1	0	0	0	0	1	0	0	0	7973	884	31	1	2415	1	JAG1	20	10630209	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08		10630209	52395311	112	48874											
PCSK2	5126	broad.mit.edu	37	chr20	17434530	17434530	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacggcaggactgccctgtaCgacgagagctgctcttccac	8	7	12	14	3	1	1	0	0	1	1	2	5	2	2	2	2	4	4	2	2	1	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:17434530C>T	uc002wpm.2	+	9	1349	c.1029C>T	c.(1027-1029)TAC>TAT	p.Y343Y	PCSK2_uc002wpl.2_Silent_p.Y324Y|PCSK2_uc010zrm.1_Silent_p.Y308Y	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	343	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity	p.Y343Y(1)		ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGCCCTGTACGACGAGAGCT	0.597													24	50					0	0	0	0	T	17434530	T	T	17434530	2	4	269	1	0	0	0	0	0	0	0	1	11655	547	19	1		1	PCSK2	20	17434530	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	6804321	17434530	45590990	113	48875											
CD93	22918	broad.mit.edu	37	chr20	23065975	23065975	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cggaatcctggtcggcagccGcagaggaaggagccatcccc	9	4	14	14	3	0	1	0	0	0	1	3	4	2	4	5	5	2	2	5	5	2	0			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:23065975G>A	uc002wsv.2	-	1	1003	c.855C>T	c.(853-855)TGC>TGT	p.C285C		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	285	EGF-like 1.|Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GTCGGCAGCCGCAGAGGAAGG	0.647													18	125					0	0	0	0	A	23065975	A	A	23065975	2	1	269	1	0	0	0	0	0	0	0	1	3062	1079	38	1		1	CD93	20	23065975	Silent	SNP	G	TCGA-CV-7438-01A-21D-2129-08	5631445	23065975	39959545	114	48876											
MANBAL	63905	broad.mit.edu	37	chr20	35929759	35929759	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggactcttcctgggagccatCttccagctcatctgtgtgct	5	13	10	13	0	4	0	1	0	3	0	6	2	6	2	3	2	3	2	3	2	0	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:35929759C>T	uc002xgu.2	+	3	305	c.93C>T	c.(91-93)ATC>ATT	p.I31I	MANBAL_uc002xgv.2_Silent_p.I31I|MANBAL_uc002xgw.2_RNA|MANBAL_uc010gfx.2_RNA|MANBAL_uc010gfy.2_RNA	NM_022077	NP_071360	Q9NQG1	MANBL_HUMAN	mannosidase, beta A, lysosomal-like	31	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(115;0.00878)				TGGGAGCCATCTTCCAGCTCA	0.602													5	140					0	0	0	0	T	35929759	T	T	35929759	2	4	269	1	0	0	0	0	0	0	0	1	9273	903	32	2		2	MANBAL	20	35929759	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	12863784	35929759	27095761	115	48877											
LPIN3	64900	broad.mit.edu	37	chr20	39978495	39978495	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcccagtcccctaagagcCgagtcccacatgcagtgggc	9	5	12	15	1	0	1	0	0	0	1	2	3	2	1	5	1	3	1	5	1	1	1	rs150401004	byFrequency	TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:39978495C>T	uc002xjx.2	+	6	811	c.720C>T	c.(718-720)GCC>GCT	p.A240A	LPIN3_uc010ggh.2_Silent_p.A241A|LPIN3_uc010zwf.1_RNA	NM_022896	NP_075047	Q9BQK8	LPIN3_HUMAN	lipin 3	240					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.000739)				CCCTAAGAGCCGAGTCCCACA	0.637													12	58					0	0	0	0	T	39978495	T	T	39978495	2	4	269	1	0	0	0	0	0	0	0	1	8970	639	23	1		1	LPIN3	20	39978495	Silent	SNP	C	TCGA-CV-7438-01A-21D-2129-08	4048736	39978495	23047025	116	48878											
WFDC8	90199	broad.mit.edu	37	chr20	44181876	44181876	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgaaggtggacactccttaCgttcagtgaaagggaagagt	13	9	13	6	1	1	3	1	2	0	1	2	5	2	5	1	3	1	1	1	3	4	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr20:44181876C>T	uc002xow.2	-	5	564	c.485G>A	c.(484-486)CGT>CAT	p.R162H	WFDC8_uc002xox.2_Missense_Mutation_p.R162H	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	162	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				ACACTCCTTACGTTCAGTGAA	0.488													11	58					0	0	0	0	T	44181876	T	T	44181876	3	4	269	1	0	0	0	0	1	0	0	0	17424	536	19	1	248	1	WFDC8	20	44181876	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	4203381	44181876	18843644	117	48879											
RRP1	8568	broad.mit.edu	37	chr21	45213246	45213246	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagaccatgaatcgcgagtgGacgggcattgacaggctgcg	10	6	15	10	4	0	3	0	2	0	1	1	5	0	4	1	3	1	2	1	3	1	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr21:45213246G>T	uc002zds.2	+	4	414	c.321G>T	c.(319-321)TGG>TGT	p.W107C	RRP1_uc011aez.1_Missense_Mutation_p.W107C|RRP1_uc010gpk.1_5'UTR|RRP1_uc010gpl.1_Missense_Mutation_p.W5C	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	107					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		ATCGCGAGTGGACGGGCATTG	0.612													9	122					4.68919e-08	5.12153e-08	1	0	T	45213246	T	T	45213246	3	4	269	1	0	0	0	0	1	0	0	0	13750	1183	41	2	335	2	RRP1	21	45213246	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08		45213246	2916649	118	48880											
CABIN1	23523	broad.mit.edu	37	chr22	24480679	24480679	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaccattgtgcctcgcacaGagaggccagcccttagcctg	8	7	10	16	1	0	1	0	0	0	1	1	2	0	1	6	1	3	1	6	1	1	2	rs35231087		TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chr22:24480679G>C	uc002zzi.1	+	21	3185	c.3058G>C	c.(3058-3060)GAG>CAG	p.E1020Q	CABIN1_uc002zzj.1_Missense_Mutation_p.E970Q|CABIN1_uc002zzl.1_Missense_Mutation_p.E1020Q	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1020					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GCCTCGCACAGAGAGGCCAGC	0.557													21	66					0	0	0	0	C	24480679	C	C	24480679	3	2	269	1	0	0	0	0	1	0	0	0	2540	943	33	2	3136	2	CABIN1	22	24480679	Missense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08		24480679	26823887	119	48881											
DMD	1756	broad.mit.edu	37	chrX	32380945	32380945	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaaatggctgcaaatcgaTggttgagctctgagatttgg	10	12	14	5	1	1	3	0	3	1	1	2	5	1	3	0	3	2	4	0	3	2	2			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:32380945T>C	uc004dda.1	-	37	5529	c.5285A>G	c.(5284-5286)CAT>CGT	p.H1762R	DMD_uc004dcw.2_Missense_Mutation_p.H418R|DMD_uc004dcx.2_Missense_Mutation_p.H421R|DMD_uc004dcz.2_Missense_Mutation_p.H1639R|DMD_uc004dcy.1_Missense_Mutation_p.H1758R|DMD_uc004ddb.1_Missense_Mutation_p.H1754R|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1762	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGCAAATCGATGGTTGAGCTC	0.483													30	103					0	0	0	0	C	32380945	C	C	32380945	3	2	269	1	0	0	0	0	1	0	0	0	4602	1464	51	5	6092	5	DMD	23	32380945	Missense_Mutation	SNP	T	TCGA-CV-7438-01A-21D-2129-08		32380945	122889615	120	48882											
ZXDA	7789	broad.mit.edu	37	chrX	57935933	57935933	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggtggtgaaggtccagcCgcagccacccagggggcatt	9	5	16	11	1	0	2	0	1	0	1	1	2	1	2	4	5	2	2	4	5	1	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:57935933C>T	uc004dve.2	-	1	1135	c.922G>A	c.(922-924)GGC>AGC	p.G308S		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	308	Required for interaction with ZXDC.|C2H2-type 2.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AAGGTCCAGCCGCAGCCACCC	0.627													7	24					0	0	0	0	T	57935933	T	T	57935933	3	4	269	1	0	0	0	0	1	0	0	0	18317	652	23	1	1481	1	ZXDA	23	57935933	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	25554988	57935933	97334627	121	48883											
COL4A6	1288	broad.mit.edu	37	chrX	107417817	107417817	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggagctccaggtaggccTggtggtccaggtcgaccagc	7	6	15	13	1	0	0	0	0	0	0	3	2	2	1	5	6	2	2	5	6	1	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:107417817T>C	uc004enw.3	-	31	3097	c.2994A>G	c.(2992-2994)CCA>CCG	p.P998P	COL4A6_uc004env.3_Silent_p.P997P|COL4A6_uc011msn.1_Silent_p.P997P|COL4A6_uc010npk.2_Silent_p.P997P	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	998	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CAGGTAGGCCTGGTGGTCCAG	0.537									Alport_syndrome_with_Diffuse_Leiomyomatosis				17	45					0	0	0	0	C	107417817	C	C	107417817	2	2	269	1	0	0	0	0	0	0	0	1	3710	1567	55	5		5	COL4A6	23	107417817	Silent	SNP	T	TCGA-CV-7438-01A-21D-2129-08	49481884	107417817	47852743	122	48884											
ZNF449	203523	broad.mit.edu	37	chrX	134483215	134483215	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaactatggtgctactggaGaatgtcagaactttctggac	11	12	11	7	0	2	3	1	1	1	2	2	5	2	4	0	3	4	1	0	3	5	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:134483215G>T	uc004eys.2	+	3	700	c.535G>T	c.(535-537)GAA>TAA	p.E179*	ZNF449_uc004eyq.1_3'UTR|ZNF449_uc004eyt.2_Nonsense_Mutation_p.E59*	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	179					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TGCTACTGGAGAATGTCAGAA	0.537													10	99					7.48243e-07	8.058e-07	1	0	T	134483215	T	T	134483215	4	4	269	1	0	0	0	0	0	1	0	0	17987	943	33	2	541	2	ZNF449	23	134483215	Nonsense_Mutation	SNP	G	TCGA-CV-7438-01A-21D-2129-08	27065398	134483215	20787345	123	48885											
SLC9A6	10479	broad.mit.edu	37	chrX	135106627	135106627	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggcaccactgcaatgctgtCatgcttgcatatcaggtaag	10	11	10	10	0	2	0	2	0	0	0	2	0	2	0	1	2	4	6	1	2	3	3			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:135106627C>T	uc004ezj.2	+	12	1581	c.1505C>T	c.(1504-1506)TCA>TTA	p.S502L	SLC9A6_uc004ezk.2_Missense_Mutation_p.S534L	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	502	Helical; (Potential).				regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GCAATGCTGTCATGCTTGCAT	0.378													19	119					0	0	0	0	T	135106627	T	T	135106627	3	4	269	1	0	0	0	0	1	0	0	0	14782	838	29	2	1647	2	SLC9A6	23	135106627	Missense_Mutation	SNP	C	TCGA-CV-7438-01A-21D-2129-08	623412	135106627	20163933	124	48886											
TREX2	11219	broad.mit.edu	37	chrX	152710829	152710829	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atctcgggctccacactgggGagcccagtggcttccaggtc	6	8	13	14	1	1	0	0	0	1	0	5	1	3	1	3	5	1	2	3	5	0	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:152710829G>A	uc010nue.1	-	3	302	c.186C>T	c.(184-186)CTC>CTT	p.L62L	TREX2_uc010nud.1_Silent_p.L20L|TREX2_uc011myp.1_Silent_p.L20L|HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA	NM_080701	NP_542432	Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	63					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			large_intestine(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCACACTGGGGAGCCCAGTGG	0.622								Editing_and_processing_nucleases					5	6					0	0	0	0	A	152710829	A	A	152710829	2	1	269	1	0	0	0	0	0	0	0	1	16544	1161	41	2		2	TREX2	23	152710829	Silent	SNP	G	TCGA-CV-7438-01A-21D-2129-08	17604202	152710829	2559731	125	48887											
FAM3A	60343	broad.mit.edu	37	chrX	153740200	153740200	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgcagtcaccgagctctcTggacctgtggatacagagtg	8	9	12	12	1	2	1	1	0	1	1	3	4	2	3	3	2	3	2	3	2	1	1			TCGA-CV-7438-01A-21D-2129-08	TCGA-CV-7438-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	6fd3ecf3-c87c-46c3-81f0-11e2f8936d61	5325b2e0-579a-4463-bf95-a1e6da6b0a33	g.chrX:153740200T>A	uc004fls.1	-	3	409	c.132A>T	c.(130-132)CCA>CCT	p.P44P	FAM3A_uc004flt.1_Silent_p.P58P|FAM3A_uc011mzp.1_Silent_p.P44P|FAM3A_uc004flu.1_Silent_p.P58P|FAM3A_uc011mzq.1_Silent_p.P44P|FAM3A_uc004flw.1_Silent_p.P44P	NM_021806	NP_068578	P98173	FAM3A_HUMAN	family 3, member A protein precursor	44						extracellular region				large_intestine(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCGAGCTCTCTGGACCTGTGG	0.632											OREG0003614	type=REGULATORY REGION|Gene=FAM3A|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	12	36					0	0	0	0	A	153740200	A	A	153740200	2	1	269	1	0	0	0	0	0	0	0	1	5588	1567	55	5		5	FAM3A	23	153740200	Silent	SNP	T	TCGA-CV-7438-01A-21D-2129-08	1029371	153740200	1530360	126	48888											
MMEL1	79258	broad.mit.edu	37	chr1	2540804	2540804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgcaggagcggtacagcGtcctggccttctccacagcc	7	8	11	15	2	2	0	1	0	1	0	4	1	3	1	4	3	5	2	4	3	1	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:2540804G>A	uc001ajy.2	-	6	723	c.509C>T	c.(508-510)ACG>ATG	p.T170M	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	170	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GCGGTACAGCGTCCTGGCCTT	0.687													6	5					0	0	0	0	A	2540804	A	A	2540804	3	1	270	1	0	0	0	0	1	0	0	0	9699	1145	40	1	1906	1	MMEL1	1	2540804	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08		2540804	246709817	1	48889											
CAMTA1	23261	broad.mit.edu	37	chr1	7724486	7724486	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgccagcaaacccctccccGtcgagcagaacacccacagc	12	2	7	20	3	0	1	0	0	0	1	2	2	1	1	6	0	5	2	6	0	2	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:7724486G>T	uc001aoi.2	+	9	2086	c.1879G>T	c.(1879-1881)GTC>TTC	p.V627F		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	627					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		ACCCCTCCCCGTCGAGCAGAA	0.652													79	81					2.27196e-54	3.20677e-54	1	0	T	7724486	T	T	7724486	3	4	270	1	0	0	0	0	1	0	0	0	2625	1145	40	3	1913	3	CAMTA1	1	7724486	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	5183682	7724486	241526135	2	48890											
NPPB	4879	broad.mit.edu	37	chr1	11918291	11918291	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctttgcagcccaggccactgGaggagctgatccggtccatc	7	8	12	14	1	0	1	0	1	0	0	3	3	2	3	4	4	3	2	4	4	0	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:11918291G>A	uc001atj.2	-	2	470	c.368C>T	c.(367-369)TCC>TTC	p.S123F		NM_002521	NP_002512	P16860	ANFB_HUMAN	natriuretic peptide precursor B preproprotein	123					body fluid secretion|cGMP biosynthetic process|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation	extracellular space	diuretic hormone activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)	Carvedilol(DB01136)|Nesiritide(DB04899)|Testosterone(DB00624)	CAGGCCACTGGAGGAGCTGAT	0.602													23	32					0	0	0	0	A	11918291	A	A	11918291	3	1	270	1	0	0	0	0	1	0	0	0	10646	1174	41	2	44	2	NPPB	1	11918291	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	4193805	11918291	237332330	3	48891											
EPHA2	1969	broad.mit.edu	37	chr1	16477390	16477390	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccaccccgaaggcttacataCccctttgccatacgggtgtg	8	9	9	15	2	0	0	0	0	0	0	0	1	0	0	6	2	4	1	6	2	4	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:16477390C>G	uc001aya.1	-	2	290	c.153_splice	c.e2+1	p.G51_splice	EPHA2_uc010oca.1_Splice_Site_p.G51_splice	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor						activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GGCTTACATACCCCTTTGCCA	0.453													37	74					0	0	0	0	G	16477390	G	G	16477390	5	3	270	1	0	0	0	0	0	0	1	0	5191	521	18	4	2840	4	EPHA2	1	16477390	Splice_Site	SNP	C	TCGA-CV-7440-01A-11D-2129-08	4559099	16477390	232773231	4	48892											
ARID1A	8289	broad.mit.edu	37	chr1	27100151	27100151	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgccttccaacccagactCggggatgtattctcctagcc	8	10	8	15	1	1	1	0	0	1	1	4	2	2	2	5	2	3	1	5	2	3	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:27100151C>A	uc001bmv.1	+	16	4320	c.3947C>A	c.(3946-3948)TCG>TAG	p.S1316*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.S1315*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.S1316*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.S933*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.S162*|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1316					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AACCCAGACTCGGGGATGTAT	0.507			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								41	38					9.39024e-22	1.27877e-21	1	0	A	27100151	A	A	27100151	4	1	270	1	0	0	0	0	0	1	0	0	913	893	31	3	4009	3	ARID1A	1	27100151	Nonsense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	10622761	27100151	222150470	5	48893											
RLF	6018	broad.mit.edu	37	chr1	40705888	40705888	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgactctacaattcatgaGaacctgactgcaatcccacc	13	9	6	13	0	2	3	1	3	1	1	3	4	3	3	3	0	3	1	3	0	4	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:40705888G>C	uc001cfc.3	+	8	5545	c.5514G>C	c.(5512-5514)GAG>GAC	p.E1838D	RLF_uc001cfd.3_Missense_Mutation_p.E1529D	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1838					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			CAATTCATGAGAACCTGACTG	0.398													15	85					0	0	0	0	C	40705888	C	C	40705888	3	2	270	1	0	0	0	0	1	0	0	0	13454	933	33	2	5544	2	RLF	1	40705888	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	13605737	40705888	208544733	6	48894											
RIMS3	9783	broad.mit.edu	37	chr1	41101587	41101587	+	Splice_Site	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcacggggctgcacgcaCgtgccgtcggagctgttgct	6	7	15	13	5	0	0	0	0	0	0	1	1	0	1	1	3	5	7	1	3	0	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:41101587C>A	uc001cfu.1	-	4	828	c.359_splice	c.e4+1	p.T120_splice	RIMS3_uc001cfv.1_Splice_Site_p.T120_splice	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3						neurotransmitter transport	cell junction|synapse					0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			GCTGCACGCACGTGCCGTCGG	0.667													14	55					1.15088e-07	1.31598e-07	1	0	A	41101587	A	A	41101587	5	1	270	1	0	0	0	0	0	0	1	0	13434	550	19	3	586	3	RIMS3	1	41101587	Splice_Site	SNP	C	TCGA-CV-7440-01A-11D-2129-08	395699	41101587	208149034	7	48895											
EIF2B3	8891	broad.mit.edu	37	chr1	45444037	45444037	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctgcagttcccatgtcagCgtcatcaggaatacacacaa	13	9	7	12	1	4	0	3	0	1	0	5	1	5	1	1	1	3	2	1	1	3	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:45444037C>T	uc001cmt.1	-	3	371	c.244G>A	c.(244-246)GCT>ACT	p.A82T	EIF2B3_uc001cmu.1_Missense_Mutation_p.A82T|EIF2B3_uc001cmv.1_Missense_Mutation_p.A82T|EIF2B3_uc001cmw.2_Missense_Mutation_p.A82T	NM_020365	NP_065098	Q9NR50	EI2BG_HUMAN	eukaryotic translation initiation factor 2B,	82					negative regulation of translational initiation in response to stress|oligodendrocyte development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	nucleotidyltransferase activity|protein binding|translation initiation factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CCCATGTCAGCGTCATCAGGA	0.363													62	106					0	0	0	0	T	45444037	T	T	45444037	3	4	270	1	0	0	0	0	1	0	0	0	5024	768	27	1	1191	1	EIF2B3	1	45444037	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	4342450	45444037	203806584	8	48896											
WDR78	79819	broad.mit.edu	37	chr1	67292591	67292591	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggagaccaggcaacgtcgtAaacaacagaagtagctggat	15	6	12	8	2	0	2	0	0	0	2	1	4	0	3	1	3	4	4	1	3	6	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:67292591A>C	uc001dcx.2	-	15	2307	c.2251T>G	c.(2251-2253)TAC>GAC	p.Y751D	WDR78_uc009waw.2_Missense_Mutation_p.Y464D|WDR78_uc009wax.2_RNA	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	751	WD 5.									ovary(2)	2						GCAACGTCGTAAACAACAGAA	0.398													21	94					0	0	0	0	C	67292591	C	C	67292591	3	2	270	1	0	0	0	0	1	0	0	0	17396	362	13	5	307	5	WDR78	1	67292591	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	21848554	67292591	181958030	9	48897											
PIGK	10026	broad.mit.edu	37	chr1	77627356	77627356	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaatcgttcatacatggatgCtccttggcaagtatcaataa	14	12	7	8	1	2	0	2	0	0	0	4	1	3	1	1	2	2	4	1	2	6	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:77627356C>A	uc001dhk.2	-	7	670	c.625G>T	c.(625-627)GCA>TCA	p.A209S	PIGK_uc010orj.1_Missense_Mutation_p.A133S|PIGK_uc009wbx.2_Missense_Mutation_p.A115S|PIGK_uc001dhl.1_Missense_Mutation_p.A209S	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	209	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						TACATGGATGCTCCTTGGCAA	0.358													35	59					1.36161e-19	1.83581e-19	1	0	A	77627356	A	A	77627356	3	1	270	1	0	0	0	0	1	0	0	0	11945	797	28	4	582	4	PIGK	1	77627356	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	10334765	77627356	171623265	10	48898											
COL11A1	1301	broad.mit.edu	37	chr1	103405901	103405901	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accttgtctccgtcttccccAggggagccggcaggaccagc	6	7	12	16	2	2	0	0	0	2	0	4	2	3	2	6	4	2	1	6	4	0	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:103405901A>T	uc001dul.2	-	43	3684	c.3366T>A	c.(3364-3366)CCT>CCA	p.P1122P	COL11A1_uc001duk.2_Silent_p.P318P|COL11A1_uc001dum.2_Silent_p.P1134P|COL11A1_uc001dun.2_Silent_p.P1083P|COL11A1_uc009weh.2_Silent_p.P1006P	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1122	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CGTCTTCCCCAGGGGAGCCGG	0.463													25	39					0	0	0	0	T	103405901	T	T	103405901	2	4	270	1	0	0	0	0	0	0	0	1	3682	175	7	5		5	COL11A1	1	103405901	Silent	SNP	A	TCGA-CV-7440-01A-11D-2129-08	25778545	103405901	145844720	11	48899											
AMPD1	270	broad.mit.edu	37	chr1	115216688	115216688	+	Frame_Shift_Del	DEL	A	-	-																															ttgggctaagaaaaacaagtActgtagcacgggactctgaa																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:115216688delA	uc001efe.1	-	14	1900	c.1816delT	c.(1816-1818)TACfs	p.Y606fs	AMPD1_uc001eff.1_Frame_Shift_Del_p.Y602fs	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	606					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	AAAAACAAGTACTGTAGCACG	0.343													---	---	---								-	115216688	-	-	115216688	7	5	270	1	0	1	0	1	0	0	0	0	585	391	14	0	439	0	AMPD1	1	115216688	Frame_Shift_Del	DEL	A	TCGA-CV-7440-01A-11D-2129-08	11810787	115216688	134033933	12	48900											
GJA8	2703	broad.mit.edu	37	chr1	147380527	147380527	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctggaggggaccctgctgAggacctacatctgccacatc	8	7	13	13	0	1	1	0	1	1	0	2	4	1	4	3	5	3	2	3	5	1	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:147380527A>T	uc001epu.1	+	2	508	c.445A>T	c.(445-447)AGG>TGG	p.R149W		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	149	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					GACCCTGCTGAGGACCTACAT	0.607													20	115					0	0	0	0	T	147380527	T	T	147380527	3	4	270	1	0	0	0	0	1	0	0	0	6442	295	11	5	447	5	GJA8	1	147380527	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	32163839	147380527	101870094	13	48901											
FMO4	2329	broad.mit.edu	37	chr1	171310604	171310604	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgactacattgcctacatgGatgatatcgctgcctgcata	10	13	8	10	1	0	2	0	2	0	0	1	3	0	3	2	1	5	2	2	1	4	6	rs67000791		TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:171310604G>T	uc001gho.2	+	10	1520	c.1303G>T	c.(1303-1305)GAT>TAT	p.D435Y		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	435					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGCCTACATGGATGATATCGC	0.473													18	34					1.45105e-14	1.88151e-14	1	0	T	171310604	T	T	171310604	3	4	270	1	0	0	0	0	1	0	0	0	5989	1174	41	2	1333	2	FMO4	1	171310604	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	23930077	171310604	77940017	14	48902											
QSOX1	5768	broad.mit.edu	37	chr1	180159622	180159622	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgccaggggagtgagccgCatttccggggctttccctgc	4	9	15	13	2	0	1	0	1	0	0	2	2	2	2	4	4	3	3	4	4	0	2	rs143670617	byFrequency	TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:180159622C>T	uc001gnz.2	+	10	1270	c.1195C>T	c.(1195-1197)CAT>TAT	p.H399Y	QSOX1_uc001gny.2_Missense_Mutation_p.H399Y|QSOX1_uc001goa.2_Missense_Mutation_p.H399Y	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	399	ERV/ALR sulfhydryl oxidase.				cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						GAGTGAGCCGCATTTCCGGGG	0.557													50	121					0	0	0	0	T	180159622	T	T	180159622	3	4	270	1	0	0	0	0	1	0	0	0	12948	710	25	4	1233	4	QSOX1	1	180159622	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	8849018	180159622	69090999	15	48903											
RGL1	23179	broad.mit.edu	37	chr1	183876207	183876207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaccacctcgcccaagcctCggaagagcatggtgaagaga	12	4	12	13	2	0	3	0	1	0	2	2	5	0	4	4	2	2	2	4	2	3	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:183876207C>T	uc001gqo.2	+	14	1691	c.1534C>T	c.(1534-1536)CGG>TGG	p.R512W	RGL1_uc010pof.1_Missense_Mutation_p.R317W|RGL1_uc001gqm.2_Missense_Mutation_p.R547W|RGL1_uc010pog.1_Missense_Mutation_p.R510W|RGL1_uc010poh.1_Missense_Mutation_p.R510W|RGL1_uc010poi.1_Missense_Mutation_p.R483W	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	512					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						GCCCAAGCCTCGGAAGAGCAT	0.557													7	8					0	0	0	0	T	183876207	T	T	183876207	3	4	270	1	0	0	0	0	1	0	0	0	13341	875	31	1	1693	1	RGL1	1	183876207	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	3716585	183876207	65374414	16	48904											
ASPM	259266	broad.mit.edu	37	chr1	197091420	197091420	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taggagctctttgtatagctCtgaagtattttctattatgc	9	18	8	6	0	3	1	0	1	3	0	3	2	3	2	0	1	3	4	0	1	7	9			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:197091420C>G	uc001gtu.2	-	15	3867	c.3610G>C	c.(3610-3612)GAG>CAG	p.E1204Q	ASPM_uc001gtv.2_Missense_Mutation_p.E1204Q|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1204	CH 2.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTGTATAGCTCTGAAGTATTT	0.363													18	45					0	0	0	0	G	197091420	G	G	197091420	3	3	270	1	0	0	0	0	1	0	0	0	1058	922	32	2	6879	2	ASPM	1	197091420	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	13215213	197091420	52159201	17	48905											
PIK3C2B	5287	broad.mit.edu	37	chr1	204425081	204425081	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggaccaggtcatgcttgcGgctcccgggcactgccgtct	4	9	13	15	3	2	0	1	0	1	0	3	1	3	1	3	4	3	3	3	4	0	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:204425081G>A	uc001haw.2	-	12	2325	c.1846C>T	c.(1846-1848)CGC>TGC	p.R616C	PIK3C2B_uc010pqv.1_Missense_Mutation_p.R616C|PIK3C2B_uc001hax.1_Missense_Mutation_p.R616C|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	616					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TCATGCTTGCGGCTCCCGGGC	0.612													39	64					0	0	0	0	A	204425081	A	A	204425081	3	1	270	1	0	0	0	0	1	0	0	0	11965	1116	39	1	3150	1	PIK3C2B	1	204425081	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	7333661	204425081	44825540	18	48906											
IL19	29949	broad.mit.edu	37	chr1	207010323	207010323	+	Frame_Shift_Del	DEL	A	-	-																															caagctaaggacaccttcccAaatgtcactatcctgtccac																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:207010323delA	uc001hep.2	+	4	1104	c.165delA	c.(163-165)CCAfs	p.P55fs	IL19_uc001heo.2_Frame_Shift_Del_p.P93fs|IL19_uc010prx.1_Frame_Shift_Del_p.P55fs	NM_013371	NP_037503	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 2 precursor	55					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			ACACCTTCCCAAATGTCACTA	0.418													---	---	---								-	207010323	-	-	207010323	7	5	270	1	0	1	0	1	0	0	0	0	7688	117	5	0	289	0	IL19	1	207010323	Frame_Shift_Del	DEL	A	TCGA-CV-7440-01A-11D-2129-08	2585242	207010323	42240298	19	48907											
KCTD3	51133	broad.mit.edu	37	chr1	215752341	215752341	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttttcttcttctctttatAggtattcctagtcgtaaaat	8	21	5	7	1	3	0	0	0	3	0	6	0	4	0	1	1	0	3	1	1	6	11			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:215752341A>G	uc001hks.2	+	7	692	c.398_splice	c.e7-2	p.G133_splice	KCTD3_uc001hkt.2_Splice_Site_p.G133_splice|KCTD3_uc010pub.1_Splice_Site_p.G31_splice|KCTD3_uc009xdn.2_5'Flank	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain							voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		TTCTCTTTATAGGTATTCCTA	0.333													4	28					0	0	0	0	G	215752341	G	G	215752341	5	3	270	1	0	0	0	0	0	0	1	0	8149	434	15	5	422	5	KCTD3	1	215752341	Splice_Site	SNP	A	TCGA-CV-7440-01A-11D-2129-08	8742018	215752341	33498280	20	48908											
EGLN1	54583	broad.mit.edu	37	chr1	231556851	231556851	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttcgcagccgggctcctTgccctcgatccaggtgatct	4	11	12	14	3	1	1	0	1	1	0	5	2	3	1	4	3	2	3	4	3	0	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:231556851T>G	uc001huv.2	-	1	3940	c.784A>C	c.(784-786)AAG>CAG	p.K262Q	EGLN1_uc001huu.3_5'Flank	NM_022051	NP_071334	Q9GZT9	EGLN1_HUMAN	egl nine homolog 1	262					negative regulation of sequence-specific DNA binding transcription factor activity|oxygen homeostasis|response to hypoxia	cytosol	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline dioxygenase activity|protein binding|zinc ion binding				0		Prostate(94;0.194)|Acute lymphoblastic leukemia(190;0.244)			Vitamin C(DB00126)	CCGGGCTCCTTGCCCTCGATC	0.592													58	66					0	0	0	0	G	231556851	G	G	231556851	3	3	270	1	0	0	0	0	1	0	0	0	4990	1821	63	5	516	5	EGLN1	1	231556851	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	15804510	231556851	17693770	21	48909											
SLC35F3	148641	broad.mit.edu	37	chr1	234367481	234367481	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagcagtctgtgaagcagcGatacaggtaggcgcgtcctg	10	7	15	9	3	1	1	0	1	1	0	2	3	2	1	1	2	4	3	1	2	4	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:234367481G>A	uc001hwa.1	+	2	623	c.395G>A	c.(394-396)CGA>CAA	p.R132Q	SLC35F3_uc001hvy.1_Missense_Mutation_p.R201Q	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	132					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			GTGAAGCAGCGATACAGGTAG	0.597													23	138					0	0	0	0	A	234367481	A	A	234367481	3	1	270	1	0	0	0	0	1	0	0	0	14654	1058	37	1	612	1	SLC35F3	1	234367481	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	2810630	234367481	14883140	22	48910											
RBM34	23029	broad.mit.edu	37	chr1	235324636	235324636	+	5'Flank	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggccacgccccctcccctccGgcagtcggccgccgggcggc	2	3	14	22	6	0	0	0	0	0	0	3	0	2	0	8	5	0	1	8	5	0	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:235324636G>C	uc001hwn.2	-						RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_5'Flank	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1							nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			CCTCCCCTCCGGCAGTCGGCC	0.672													22	41					0	0	0	0	C	235324636	C	C	235324636	1	2	270	0	1	0	0	0	0	0	0	0	13196	1131	39	3		3	RBM34	1	235324636	5'Flank	SNP	G	TCGA-CV-7440-01A-11D-2129-08	957155	235324636	13925985	23	48911											
TRIM58	25893	broad.mit.edu	37	chr1	248028155	248028155	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgggagagcaagagccggcTggtccagcagagcaaggccc	10	2	17	12	2	0	3	0	0	0	3	1	4	1	3	3	4	4	4	3	4	2	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:248028155T>A	uc001ido.2	+	3	713	c.665T>A	c.(664-666)CTG>CAG	p.L222Q		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	222	Potential.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AAGAGCCGGCTGGTCCAGCAG	0.692													7	22					0	0	0	0	A	248028155	A	A	248028155	3	1	270	1	0	0	0	0	1	0	0	0	16598	1580	55	5	675	5	TRIM58	1	248028155	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	12703519	248028155	1222466	24	48912											
OR2W3	343171	broad.mit.edu	37	chr1	248059405	248059405	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taccccgctgtgggcaccacGaggtggaccacttcctgcgt	6	8	12	15	3	0	0	0	0	0	0	1	2	1	1	5	3	2	2	5	3	1	2	rs139271211		TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr1:248059405G>A	uc001idp.1	+	3	786	c.517G>A	c.(517-519)GAG>AAG	p.E173K	OR2W3_uc010pzb.1_Missense_Mutation_p.E173K	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGGGCACCACGAGGTGGACCA	0.657													41	76					0	0	0	0	A	248059405	A	A	248059405	3	1	270	1	0	0	0	0	1	0	0	0	11087	1059	37	1	519	1	OR2W3	1	248059405	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	31250	248059405	1191216	25	48913											
KIDINS220	57498	broad.mit.edu	37	chr2	8919048	8919048	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagtatctgagcatggaacGtctccatttgttgctgaagt	9	14	11	7	1	2	2	0	2	2	0	3	3	2	3	1	1	3	5	1	1	4	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:8919048G>T	uc002qzc.2	-	19	2774	c.2592C>A	c.(2590-2592)GAC>GAA	p.D864E	KIDINS220_uc010yiv.1_Missense_Mutation_p.D630E|KIDINS220_uc002qzd.2_Missense_Mutation_p.D822E|KIDINS220_uc010yiw.1_Missense_Mutation_p.D865E	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	864	KAP NTPase.|Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AGCATGGAACGTCTCCATTTG	0.398													17	114					1.33834e-09	1.60482e-09	1	0	T	8919048	T	T	8919048	3	4	270	1	0	0	0	0	1	0	0	0	8310	1136	40	3	2771	3	KIDINS220	2	8919048	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08		8919048	234280325	26	48914											
GALNT14	79623	broad.mit.edu	37	chr2	31133837	31133837	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggttgacgacgatttccttgCcgttctcggtgccatcaccg	5	12	11	13	5	2	1	1	1	1	0	4	3	3	1	4	2	2	2	4	2	0	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:31133837C>G	uc002rnr.2	-	15	2208	c.1589G>C	c.(1588-1590)GGC>GCC	p.G530A	GALNT14_uc002rnq.2_Missense_Mutation_p.G510A|GALNT14_uc002rns.2_Missense_Mutation_p.G535A|GALNT14_uc010ymr.1_Missense_Mutation_p.G495A	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	530	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GATTTCCTTGCCGTTCTCGGT	0.542													16	71					0	0	0	0	G	31133837	G	G	31133837	3	3	270	1	0	0	0	0	1	0	0	0	6247	739	26	4	73	4	GALNT14	2	31133837	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	22214789	31133837	212065536	27	48915											
SMEK2	57223	broad.mit.edu	37	chr2	55831140	55831140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattttttcccagatctcatCacagccagctttctcctgaa	10	14	4	13	0	3	2	2	1	2	1	6	2	4	2	3	0	2	1	3	0	2	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:55831140C>T	uc002rzc.2	-	3	646	c.271G>A	c.(271-273)GAT>AAT	p.D91N	SMEK2_uc002rzb.2_Missense_Mutation_p.D91N|SMEK2_uc002rzd.2_Missense_Mutation_p.D91N|SMEK2_uc002rza.2_5'UTR	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	91	WH1.					microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CAGATCTCATCACAGCCAGCT	0.299													16	65					0	0	0	0	T	55831140	T	T	55831140	3	4	270	1	0	0	0	0	1	0	0	0	14858	826	29	2	2338	2	SMEK2	2	55831140	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	24697303	55831140	187368233	28	48916											
RNF181	51255	broad.mit.edu	37	chr2	85824002	85824006	+	Frame_Shift_Del	DEL	TGCCT	-	-																															ggaggagactgccattgagaTgccttgccatcaccttttcc																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:85824002_85824006delTGCCT	uc002spv.1	+	3	325_329	c.275_279delTGCCT	c.(274-279)ATGCCTfs	p.M92fs		NM_016494	NP_057578	Q9P0P0	RN181_HUMAN	ring finger protein 181	92_93	RING-type; atypical.						ligase activity|zinc ion binding				0						GCCATTGAGATGCCTTGCCATCACC	0.532													---	---	---								-	85824006	-	-	85824002	7	5	270	1	0	1	0	1	0	0	0	0	13530	1464	51	0	285	0	RNF181	2	85824002	Frame_Shift_Del	DEL	TGCCT	TCGA-CV-7440-01A-11D-2129-08	29992862	85824002	157375371	29	48917											
FER1L5	90342	broad.mit.edu	37	chr2	97370099	97370099	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacttcatctattcagctccGgtgagtggcagccatggggg	8	10	13	10	1	3	1	2	1	1	0	4	1	4	1	2	4	3	2	2	4	2	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:97370099G>A	uc010fia.2	+	51	6057	c.6057G>A	c.(6055-6057)CCG>CCA	p.P2019P	FER1L5_uc002sws.3_Silent_p.P728P|FER1L5_uc002swt.3_Silent_p.P728P|FER1L5_uc010yus.1_Silent_p.P727P	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	2019						integral to membrane				ovary(1)	1						ATTCAGCTCCGGTGAGTGGCA	0.483													58	120					0	0	0	0	A	97370099	A	A	97370099	2	1	270	1	0	0	0	0	0	0	0	1	5846	1130	39	1		1	FER1L5	2	97370099	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	11546097	97370099	145829274	30	48918											
LRP1B	53353	broad.mit.edu	37	chr2	141027836	141027836	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cacaggtacatttgtctcggGgtccagctggcatgtgccac	7	10	12	12	1	1	0	0	0	1	0	3	0	2	0	2	4	3	3	2	4	1	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:141027836G>C	uc002tvj.1	-	86	14194	c.13222C>G	c.(13222-13224)CCC>GCC	p.P4408A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4408	Extracellular (Potential).|EGF-like 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTGTCTCGGGGTCCAGCTGG	0.403										TSP Lung(27;0.18)			19	38					0	0	0	0	C	141027836	C	C	141027836	3	2	270	1	0	0	0	0	1	0	0	0	9005	1232	43	4	601	4	LRP1B	2	141027836	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	43657737	141027836	102171537	31	48919											
LRP1B	53353	broad.mit.edu	37	chr2	141128763	141128763	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttacctcatctgaaccatcAgcacaatcatattctccatt	12	14	2	13	0	5	1	3	1	2	0	6	1	5	1	3	0	3	1	3	0	4	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:141128763A>G	uc002tvj.1	-	70	11832	c.10860T>C	c.(10858-10860)GCT>GCC	p.A3620A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3620	Extracellular (Potential).|LDL-receptor class A 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGAACCATCAGCACAATCAT	0.299										TSP Lung(27;0.18)			3	21					0	0	0	0	G	141128763	G	G	141128763	2	3	270	1	0	0	0	0	0	0	0	1	9005	175	7	5		5	LRP1B	2	141128763	Silent	SNP	A	TCGA-CV-7440-01A-11D-2129-08	100927	141128763	102070610	32	48920											
LRP1B	53353	broad.mit.edu	37	chr2	141571366	141571366	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcttgttttccacatagtctAtcgatagacctgtaattaaa	12	15	6	8	1	1	1	0	0	1	1	3	2	2	1	2	0	0	3	2	0	6	8			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:141571366A>G	uc002tvj.1	-	32	6191	c.5219T>C	c.(5218-5220)ATA>ACA	p.I1740T		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1740	Extracellular (Potential).|LDL-receptor class B 16.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CACATAGTCTATCGATAGACC	0.343										TSP Lung(27;0.18)			7	58					0	0	0	0	G	141571366	G	G	141571366	3	3	270	1	0	0	0	0	1	0	0	0	9005	449	16	5	8820	5	LRP1B	2	141571366	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	442603	141571366	101628007	33	48921											
MBD5	55777	broad.mit.edu	37	chr2	149226943	149226943	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatttcatgatgccacctgtAggaccccaggccacttctag	10	10	8	13	0	2	1	1	1	1	0	2	2	2	2	5	2	1	1	5	2	3	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:149226943A>T	uc002twm.3	+	9	2419	c.1431A>T	c.(1429-1431)GTA>GTT	p.V477V	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Silent_p.V477V|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	477						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TGCCACCTGTAGGACCCCAGG	0.502													7	31					0	0	0	0	T	149226943	T	T	149226943	2	4	270	1	0	0	0	0	0	0	0	1	9400	407	15	5		5	MBD5	2	149226943	Silent	SNP	A	TCGA-CV-7440-01A-11D-2129-08	7655577	149226943	93972430	34	48922											
IFIH1	64135	broad.mit.edu	37	chr2	163134806	163134806	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caataagtttgaatccttgtCattatttctagaagtttctc	11	18	5	7	0	3	2	1	1	2	1	5	2	4	2	1	0	0	2	1	0	6	7			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:163134806C>A	uc002uce.2	-	9	1896	c.1674G>T	c.(1672-1674)ATG>ATT	p.M558I		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	558					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						GAATCCTTGTCATTATTTCTA	0.289													5	38					1.23904e-05	1.32719e-05	1	0	A	163134806	A	A	163134806	3	1	270	1	0	0	0	0	1	0	0	0	7559	826	29	2	1435	2	IFIH1	2	163134806	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	13907863	163134806	80064567	35	48923											
COL5A2	1290	broad.mit.edu	37	chr2	189962019	189962019	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttacaggtcttccttttggcCctcgctctcctcttggtccc	2	16	7	16	1	3	0	0	0	3	0	7	0	5	0	4	3	1	1	4	3	1	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:189962019C>T	uc002uqk.2	-	6	715	c.440G>A	c.(439-441)GGG>GAG	p.G147E		NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	147					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TCCTTTTGGCCCTCGCTCTCC	0.443													8	55					0	0	0	0	T	189962019	T	T	189962019	3	4	270	1	0	0	0	0	1	0	0	0	3712	623	22	4	4255	4	COL5A2	2	189962019	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	26827213	189962019	53237354	36	48924											
DNAH7	56171	broad.mit.edu	37	chr2	196834805	196834805	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccaattcctccacaaacCgttcacaccgtaactaataa	14	10	2	15	2	2	0	1	0	1	0	5	0	4	0	5	0	2	2	5	0	5	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:196834805C>T	uc002utj.3	-	17	2173	c.2072G>A	c.(2071-2073)CGG>CAG	p.R691Q		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	691	Stem (By similarity).|Potential.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CTCCACAAACCGTTCACACCG	0.323													19	54					0	0	0	0	T	196834805	T	T	196834805	3	4	270	1	0	0	0	0	1	0	0	0	4628	652	23	1	10198	1	DNAH7	2	196834805	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	6872786	196834805	46364568	37	48925											
PLCL1	5334	broad.mit.edu	37	chr2	198950188	198950188	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tatccaagtgccatgaggatCgattccagtaacttgaatcc	12	11	8	10	1	0	2	0	2	0	0	4	4	3	3	4	1	2	1	4	1	4	4	rs151231252		TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:198950188C>G	uc010fsp.2	+	2	2238	c.1947C>G	c.(1945-1947)ATC>ATG	p.I649M	PLCL1_uc002uuv.3_Missense_Mutation_p.I570M	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	649	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CCATGAGGATCGATTCCAGTA	0.423													5	45					0	0	0	0	G	198950188	G	G	198950188	3	3	270	1	0	0	0	0	1	0	0	0	12094	874	31	3	1953	3	PLCL1	2	198950188	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	2115383	198950188	44249185	38	48926											
ABCA12	26154	broad.mit.edu	37	chr2	215880315	215880315	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacaggttgcagaattcttTcattgcatcttctagtttgg	9	16	9	7	0	4	2	1	0	3	2	4	2	4	2	0	2	2	4	0	2	2	7			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:215880315T>A	uc002vew.2	-	15	2075	c.1855A>T	c.(1855-1857)AAA>TAA	p.K619*	ABCA12_uc002vev.2_Nonsense_Mutation_p.K301*|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	619					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CAGAATTCTTTCATTGCATCT	0.403													8	25					0	0	0	0	A	215880315	A	A	215880315	4	1	270	1	0	0	0	0	0	1	0	0	30	1792	62	5	6088	5	ABCA12	2	215880315	Nonsense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	16930127	215880315	27319058	39	48927											
ALPP	250	broad.mit.edu	37	chr2	233243704	233243716	+	Frame_Shift_Del	DEL	TGGAACCGCGAGG	-	-																															aggaggagaacccggacttcTggaaccgcgaggcagccgag																								rs61747708	byFrequency	TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:233243704_233243716delTGGAACCGCGAGG	uc002vsq.2	+	2	265_277	c.100_112delTGGAACCGCGAGG	c.(100-114)TGGAACCGCGAGGCAfs	p.W34fs	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	34_38						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		CCCGGACTTCTGGAACCGCGAGGCAGCCGAGGC	0.634													---	---	---								-	233243716	-	-	233243704	7	5	270	1	0	1	0	1	0	0	0	0	548	1580	55	0	106	0	ALPP	2	233243704	Frame_Shift_Del	DEL	TGGAACCGCGAGG	TCGA-CV-7440-01A-11D-2129-08	17363389	233243704	9955669	40	48928											
MYEOV2	150678	broad.mit.edu	37	chr2	241066107	241066107	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatattgtgctgtcttcgCtgacctctcgcctgcttctt	3	17	8	13	2	3	2	0	2	3	0	5	2	3	2	2	0	2	3	2	0	1	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr2:241066107C>A	uc002vyu.1	-	5	632	c.632G>T	c.(631-633)AGC>ATC	p.S211I		NM_138336	NP_612209	Q8WXC6	MYOV2_HUMAN	hypothetical protein LOC150678 isoform 1	Error:Variant_position_missing_in_Q8WXC6_after_alignment											0		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		GCTGTCTTCGCTGACCTCTCG	0.478													41	57					2.66277e-13	3.38784e-13	1	0	A	241066107	A	A	241066107	3	1	270	1	0	0	0	0	1	0	0	0	10079	797	28	4	130	4	MYEOV2	2	241066107	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	7822403	241066107	2133266	41	48929											
CNTN6	27255	broad.mit.edu	37	chr3	1444056	1444056	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atattttggaaacaaacaatAcatcagctgagcttctggtt	14	13	7	7	0	2	1	1	1	1	0	2	2	2	2	0	2	5	3	0	2	5	6			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr3:1444056A>G	uc003boz.2	+	22	3139	c.2872A>G	c.(2872-2874)ACA>GCA	p.T958A	CNTN6_uc011asj.1_Missense_Mutation_p.T886A|CNTN6_uc003bpa.2_Missense_Mutation_p.T958A	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	958	Fibronectin type-III 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AACAAACAATACATCAGCTGA	0.368													19	21					0	0	0	0	G	1444056	G	G	1444056	3	3	270	1	0	0	0	0	1	0	0	0	3660	391	14	5	2954	5	CNTN6	3	1444056	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08		1444056	196578374	42	48930											
ATP2B2	491	broad.mit.edu	37	chr3	10401651	10401651	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacagtgctcatggacttgcGcacggagttgaaggtgtaca	10	9	14	8	2	1	1	1	1	0	0	1	4	1	3	0	3	3	4	0	3	2	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr3:10401651G>A	uc003bvt.2	-	13	2255	c.1816C>T	c.(1816-1818)CGC>TGC	p.R606C	ATP2B2_uc003bvv.2_Missense_Mutation_p.R561C|ATP2B2_uc003bvw.2_Missense_Mutation_p.R561C|ATP2B2_uc010hdo.2_Missense_Mutation_p.R311C	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	606	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						ATGGACTTGCGCACGGAGTTG	0.577													53	42					0	0	0	0	A	10401651	A	A	10401651	3	1	270	1	0	0	0	0	1	0	0	0	1142	1087	38	1	1959	1	ATP2B2	3	10401651	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	8957595	10401651	187620779	43	48931											
KBTBD5	131377	broad.mit.edu	37	chr3	42727527	42727527	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcttggccgtcttccgtctCggcctcctgctcgactgcgc	1	12	11	17	5	2	0	0	0	2	0	6	1	4	0	4	2	3	2	4	2	0	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr3:42727527C>T	uc003clv.1	+	1	517	c.417C>T	c.(415-417)CTC>CTT	p.L139L		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	139	BACK.									ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TCTTCCGTCTCGGCCTCCTGC	0.652													52	50					0	0	0	0	T	42727527	T	T	42727527	2	4	270	1	0	0	0	0	0	0	0	1	8035	871	31	1		1	KBTBD5	3	42727527	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	32325876	42727527	155294903	44	48932											
IMPG2	50939	broad.mit.edu	37	chr3	100963144	100963144	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactaagaggctcttcctcTggaaagtgtgtggatctgtc	8	12	11	10	0	3	1	0	0	3	1	5	3	4	3	2	3	0	1	2	3	2	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr3:100963144T>C	uc003duq.1	-	13	2234	c.2031A>G	c.(2029-2031)CCA>CCG	p.P677P	IMPG2_uc011bhe.1_Silent_p.P540P	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	677	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GCTCTTCCTCTGGAAAGTGTG	0.443													3	43					0	0	0	0	C	100963144	C	C	100963144	2	2	270	1	0	0	0	0	0	0	0	1	7768	1567	55	5		5	IMPG2	3	100963144	Silent	SNP	T	TCGA-CV-7440-01A-11D-2129-08	58235617	100963144	97059286	45	48933											
GRAMD1C	54762	broad.mit.edu	37	chr3	113634611	113634611	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgtatttttcatatcagtgCtgacagaatgtttgaattgc	10	16	8	7	1	2	3	2	2	0	1	2	3	2	3	1	0	2	3	1	0	4	6			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr3:113634611C>T	uc003eaq.3	+	10	1092	c.1016C>T	c.(1015-1017)GCT>GTT	p.A339V	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA|GRAMD1C_uc003ear.2_Missense_Mutation_p.A172V|GRAMD1C_uc003eas.2_Missense_Mutation_p.A134V|GRAMD1C_uc003eat.2_5'UTR	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	339						integral to membrane				ovary(2)|skin(1)	3						CATATCAGTGCTGACAGAATG	0.338													11	40					0	0	0	0	T	113634611	T	T	113634611	3	4	270	1	0	0	0	0	1	0	0	0	6788	797	28	4	1054	4	GRAMD1C	3	113634611	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	12671467	113634611	84387819	46	48934											
DRD3	1814	broad.mit.edu	37	chr3	113866346	113866346	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatcatgagggccacgcgccGacaggagctctgtcccgtgc	7	6	14	14	4	2	1	1	1	1	0	3	4	3	2	3	2	2	1	3	2	0	0	rs141573183		TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr3:113866346G>A	uc003ebd.2	-	5	865	c.442C>T	c.(442-444)CGG>TGG	p.R148W	DRD3_uc010hqn.1_Missense_Mutation_p.R148W|DRD3_uc003ebb.1_Missense_Mutation_p.R148W|DRD3_uc003ebc.1_Missense_Mutation_p.R148W	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	148	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GCCACGCGCCGACAGGAGCTC	0.562													4	69					0	0	0	0	A	113866346	A	A	113866346	3	1	270	1	0	0	0	0	1	0	0	0	4780	1057	37	1	776	1	DRD3	3	113866346	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	231735	113866346	84156084	47	48935											
PCCB	5096	broad.mit.edu	37	chr3	135969356	135969356	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacaagcgccggaccgcgCtgctgggagggggccaacgc	10	2	16	13	5	0	0	0	0	0	0	0	2	0	2	3	4	4	2	3	4	4	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr3:135969356C>T	uc003eqy.1	+	1	190	c.139C>T	c.(139-141)CTG>TTG	p.L47L	PCCB_uc003eqz.1_Silent_p.L47L|PCCB_uc011bmc.1_Silent_p.L47L	NM_000532	NP_000523	P05166	PCCB_HUMAN	propionyl Coenzyme A carboxylase, beta	47	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity				0					Biotin(DB00121)|L-Valine(DB00161)	CCGGACCGCGCTGCTGGGAGG	0.667											OREG0015823	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	16					0	0	0	0	T	135969356	T	T	135969356	2	4	270	1	0	0	0	0	0	0	0	1	11559	796	28	4		4	PCCB	3	135969356	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	22103010	135969356	62053074	48	48936											
TRIM42	287015	broad.mit.edu	37	chr3	140409849	140409849	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaagacgtggactcttttGagatggaattctatgaagtc	12	12	11	6	1	2	4	0	2	2	3	3	7	2	6	0	2	0	0	0	2	4	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr3:140409849G>A	uc003eto.1	+	4	2091	c.1900G>A	c.(1900-1902)GAG>AAG	p.E634K		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	634	Fibronectin type-III.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						GGACTCTTTTGAGATGGAATT	0.418													19	78					0	0	0	0	A	140409849	A	A	140409849	3	1	270	1	0	0	0	0	1	0	0	0	16584	1291	45	2	1914	2	TRIM42	3	140409849	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	4440493	140409849	57612581	49	48937											
SLC7A14	57709	broad.mit.edu	37	chr3	170185021	170185021	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcctcctggctctcgcccTctgtggcgtaggagaaaccc	6	9	11	15	2	2	1	0	0	2	1	5	2	4	1	4	3	1	2	4	3	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr3:170185021T>C	uc003fgz.2	-	8	2454	c.2138A>G	c.(2137-2139)GAG>GGG	p.E713G	CLDN11_uc011bpt.1_Intron|uc003fha.1_5'Flank	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	713						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			GCTCTCGCCCTCTGTGGCGTA	0.572													24	48					0	0	0	0	C	170185021	C	C	170185021	3	2	270	1	0	0	0	0	1	0	0	0	14760	1551	54	5	181	5	SLC7A14	3	170185021	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	29775172	170185021	27837409	50	48938											
CC2D2A	57545	broad.mit.edu	37	chr4	15556795	15556795	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagagtccaagctcgacccaAatgaccccaacaatgcccct	13	5	6	17	1	0	2	0	1	0	1	2	3	1	2	6	0	3	1	6	0	4	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr4:15556795A>G	uc010idv.2	+	21	2832	c.2587A>G	c.(2587-2589)AAT>GAT	p.N863D	CC2D2A_uc003gnx.2_Missense_Mutation_p.N814D|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	863					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						GCTCGACCCAAATGACCCCAA	0.463													10	27					0	0	0	0	G	15556795	G	G	15556795	3	3	270	1	0	0	0	0	1	0	0	0	2740	14	1	5	2864	5	CC2D2A	4	15556795	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08		15556795	175597481	51	48939											
LPHN3	23284	broad.mit.edu	37	chr4	62758534	62758534	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtcgaggtacttgatgaCatgaccacacaccttccatc	10	10	8	13	1	0	3	0	3	0	0	3	4	1	3	3	1	1	2	3	1	1	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr4:62758534C>G	uc010ihh.2	+	7	1610	c.1437C>G	c.(1435-1437)GAC>GAG	p.D479E	LPHN3_uc003hcq.3_Missense_Mutation_p.D479E|LPHN3_uc003hcs.1_Missense_Mutation_p.D308E	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	479	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TACTTGATGACATGACCACAC	0.527													9	42					0	0	0	0	G	62758534	G	G	62758534	3	3	270	1	0	0	0	0	1	0	0	0	8967	477	17	4	1463	4	LPHN3	4	62758534	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	47201739	62758534	128395742	52	48940											
SEC31A	22872	broad.mit.edu	37	chr4	83748592	83748592	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgaaaaagatggtggcatgCctgtttgaccaagaggttgc	11	11	13	6	0	0	4	0	2	0	2	0	4	0	4	2	3	2	3	2	3	3	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr4:83748592C>G	uc003hnf.2	-	24	3385	c.3221G>C	c.(3220-3222)GGC>GCC	p.G1074A	SEC31A_uc003hnd.2_Missense_Mutation_p.G243A|SEC31A_uc003hne.2_Missense_Mutation_p.G823A|SEC31A_uc011ccl.1_Missense_Mutation_p.G1020A|SEC31A_uc003hnl.2_Missense_Mutation_p.G921A|SEC31A_uc003hng.2_Missense_Mutation_p.G1059A|SEC31A_uc003hnh.2_Missense_Mutation_p.G1074A|SEC31A_uc003hni.2_Missense_Mutation_p.G960A|SEC31A_uc003hnj.2_Missense_Mutation_p.G1035A|SEC31A_uc011ccm.1_Missense_Mutation_p.G1054A|SEC31A_uc011ccn.1_Missense_Mutation_p.G1059A|SEC31A_uc003hnk.2_Missense_Mutation_p.G1035A|SEC31A_uc003hnm.2_Missense_Mutation_p.G1074A	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	1074	Interaction with PDCD6.|Pro-rich.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				TGGTGGCATGCCTGTTTGACC	0.502													30	147					0	0	0	0	G	83748592	G	G	83748592	3	3	270	1	0	0	0	0	1	0	0	0	14063	739	26	4	457	4	SEC31A	4	83748592	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	20990058	83748592	107405684	53	48941											
MMRN1	22915	broad.mit.edu	37	chr4	90856493	90856493	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttacatgaaaatataaaGaagcagagtttgatgatgct	17	12	8	4	0	0	5	0	3	0	2	0	5	0	5	0	0	3	3	0	0	7	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr4:90856493G>T	uc003hst.2	+	6	1733	c.1662G>T	c.(1660-1662)AAG>AAT	p.K554N	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.K296N	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	554					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AAAATATAAAGAAGCAGAGTT	0.383													10	59					5.50884e-06	5.92419e-06	1	0	T	90856493	T	T	90856493	3	4	270	1	0	0	0	0	1	0	0	0	9723	933	33	2	1684	2	MMRN1	4	90856493	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	7107901	90856493	100297783	54	48942											
SGMS2	166929	broad.mit.edu	37	chr4	108831579	108831579	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcttttatttttttgagaAaaatgtacaaggctcaattc	13	17	5	6	0	2	1	1	1	1	1	3	2	2	1	0	1	1	2	0	1	6	7			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr4:108831579A>T	uc003hyl.3	+	7	1523	c.968A>T	c.(967-969)AAA>ATA	p.K323I	uc003hym.1_Intron|SGMS2_uc003hyn.2_Missense_Mutation_p.K323I|SGMS2_uc003hyo.2_Missense_Mutation_p.K323I	NM_001136258	NP_001129730	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	323	Cytoplasmic (Potential).				sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity	p.K323N(1)		lung(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	TTTTTTGAGAAAAATGTACAA	0.398													29	30					0	0	0	0	T	108831579	T	T	108831579	3	4	270	1	0	0	0	0	1	0	0	0	14280	14	1	5	986	5	SGMS2	4	108831579	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	17975086	108831579	82322697	55	48943											
NDST4	64579	broad.mit.edu	37	chr4	115998155	115998155	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagctaagagaacaatcaatGttcgaaaacttctccgaagt	16	10	7	8	2	2	1	1	0	1	1	4	4	2	1	1	0	3	2	1	0	8	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr4:115998155G>T	uc003ibu.2	-	2	717	c.38C>A	c.(37-39)ACA>AAA	p.T13K	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	13	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AACAATCAATGTTCGAAAACT	0.348													4	20					0.00909568	0.00923194	1	0	T	115998155	T	T	115998155	3	4	270	1	0	0	0	0	1	0	0	0	10312	1377	48	4	2632	4	NDST4	4	115998155	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	7166576	115998155	75156121	56	48944											
PCDH10	57575	broad.mit.edu	37	chr4	134073285	134073285	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgatcgaggtgcgcgaccatGggcagccgcccctttcctcc	5	8	12	16	4	0	1	0	1	0	0	3	3	2	1	6	2	2	1	6	2	0	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr4:134073285G>T	uc003iha.2	+	1	2816	c.1990G>T	c.(1990-1992)GGG>TGG	p.G664W	PCDH10_uc003igz.2_Missense_Mutation_p.G664W	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	664	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCGCGACCATGGGCAGCCGCC	0.612													5	35					0.000602214	0.000622901	1	0	T	134073285	T	T	134073285	3	4	270	1	0	0	0	0	1	0	0	0	11561	1348	47	4	1992	4	PCDH10	4	134073285	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	18075130	134073285	57080991	57	48945											
MAB21L2	10586	broad.mit.edu	37	chr4	151504953	151504953	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcagtgctgaagactctgCgggaccgccacctggagcta	8	8	12	13	2	2	2	1	1	2	1	3	4	2	4	3	2	3	2	3	2	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr4:151504953C>A	uc003ilw.2	+	1	1877	c.772C>A	c.(772-774)CGG>AGG	p.R258R	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	258					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		GAAGACTCTGCGGGACCGCCA	0.627													31	23					2.4375e-19	3.27011e-19	1	0	A	151504953	A	A	151504953	2	1	270	1	0	0	0	0	0	0	0	1	9193	759	27	3		3	MAB21L2	4	151504953	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	17431668	151504953	39649323	58	48946											
GLRB	2743	broad.mit.edu	37	chr4	158060002	158060002	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacgatttatctggcagtcaGgagatcctgtgcaattagaa	12	12	10	7	1	2	2	1	0	1	2	3	4	3	2	1	2	2	2	1	2	5	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr4:158060002G>T	uc003ipj.2	+	7	854	c.652G>T	c.(652-654)GGA>TGA	p.G218*		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	218	Extracellular (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	CTGGCAGTCAGGAGATCCTGT	0.274													12	70					2.61681e-11	3.25301e-11	1	0	T	158060002	T	T	158060002	4	4	270	1	0	0	0	0	0	1	0	0	6495	1001	35	4	674	4	GLRB	4	158060002	Nonsense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	6555049	158060002	33094274	59	48947											
KLHL2	11275	broad.mit.edu	37	chr4	166232680	166232680	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcatgtagctcccatgaaTacaaggaggagcagtgttgg	11	11	12	7	0	1	1	1	1	0	0	2	3	2	3	1	3	3	4	1	3	4	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr4:166232680T>C	uc003irb.2	+	11	1561	c.1302T>C	c.(1300-1302)AAT>AAC	p.N434N	KLHL2_uc011cjm.1_Silent_p.N438N|KLHL2_uc003irc.2_Silent_p.N346N|KLHL2_uc010ira.2_Silent_p.N87N	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	434	Kelch 3.				intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		CTCCCATGAATACAAGGAGGA	0.418													29	155					0	0	0	0	C	166232680	C	C	166232680	2	2	270	1	0	0	0	0	0	0	0	1	8413	1403	49	5		5	KLHL2	4	166232680	Silent	SNP	T	TCGA-CV-7440-01A-11D-2129-08	8172678	166232680	24921596	60	48948											
SEMA5A	9037	broad.mit.edu	37	chr5	9136622	9136622	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgggcactcaccggacaCgcagagatgctctgttccca	9	7	12	13	2	2	1	1	0	1	1	3	3	3	2	2	3	1	4	2	3	0	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:9136622C>A	uc003jek.2	-	13	2305	c.1593G>T	c.(1591-1593)GCG>GCT	p.A531A		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	531	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TCACCGGACACGCAGAGATGC	0.587													4	27					0.00024832	0.000258826	1	0	A	9136622	A	A	9136622	2	1	270	1	0	0	0	0	0	0	0	1	14102	523	19	3		3	SEMA5A	5	9136622	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08		9136622	171778638	61	48949											
SEMA5A	9037	broad.mit.edu	37	chr5	9190523	9190523	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgcatcagaatgaacttctGagcatcctgcagatttctct	11	13	7	10	0	3	4	1	2	2	2	5	4	4	4	1	0	4	3	1	0	2	2	rs147170997		TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:9190523G>C	uc003jek.2	-	11	1841	c.1129C>G	c.(1129-1131)CAG>GAG	p.Q377E		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	377	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						ATGAACTTCTGAGCATCCTGC	0.577													23	33					0	0	0	0	C	9190523	C	C	9190523	3	2	270	1	0	0	0	0	1	0	0	0	14102	1299	45	2	2147	2	SEMA5A	5	9190523	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	53901	9190523	171724737	62	48950											
CDH9	1007	broad.mit.edu	37	chr5	26988405	26988405	+	Frame_Shift_Del	DEL	C	-	-																															actgtatggaacatataggtCcagatgaataatggtatata																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:26988405delC	uc003jgs.1	-	2	205	c.36delG	c.(34-36)TGGfs	p.W12fs	CDH9_uc010iug.2_Frame_Shift_Del_p.W12fs	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	12					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ACATATAGGTCCAGATGAATA	0.348													---	---	---								-	26988405	-	-	26988405	7	5	270	1	0	1	0	1	0	0	0	0	3132	856	30	0	2377	0	CDH9	5	26988405	Frame_Shift_Del	DEL	C	TCGA-CV-7440-01A-11D-2129-08	17797882	26988405	153926855	63	48951											
HTR1A	3350	broad.mit.edu	37	chr5	63256581	63256581	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgttgcgctcatttttcctCtcgaaagaggcgggggcaca	7	10	13	11	4	2	1	1	0	1	1	4	2	3	1	1	3	1	3	1	3	1	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:63256581C>T	uc011cqt.1	-	1	966	c.966G>A	c.(964-966)GAG>GAA	p.E322E		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	322	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CATTTTTCCTCTCGAAAGAGG	0.617													7	55					0	0	0	0	T	63256581	T	T	63256581	2	4	270	1	0	0	0	0	0	0	0	1	7475	912	32	2		2	HTR1A	5	63256581	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	36268176	63256581	117658679	64	48952											
IQGAP2	10788	broad.mit.edu	37	chr5	75954373	75954373	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atttccaggaggaactagagGttgcacgattaagggaagaa	15	8	13	5	1	0	2	0	0	0	2	1	6	1	5	1	4	2	2	1	4	5	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:75954373G>T	uc003kek.2	+	21	2632	c.2410G>T	c.(2410-2412)GTT>TTT	p.V804F	IQGAP2_uc010izv.2_Missense_Mutation_p.V357F|IQGAP2_uc011csv.1_Missense_Mutation_p.V300F|IQGAP2_uc003kel.2_Missense_Mutation_p.V300F	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	804					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GGAACTAGAGGTTGCACGATT	0.448													37	45					2.19358e-23	3.01756e-23	1	0	T	75954373	T	T	75954373	3	4	270	1	0	0	0	0	1	0	0	0	7854	1261	44	4	2492	4	IQGAP2	5	75954373	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	12697792	75954373	104960887	65	48953											
TMEM167A	153339	broad.mit.edu	37	chr5	82357723	82357723	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcacacttccaaaatatacCcaacaatctgcatagaataa	18	8	4	11	0	1	1	0	0	1	1	2	1	2	1	2	1	3	2	2	1	9	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:82357723C>T	uc003khx.3	-	3	251	c.121G>A	c.(121-123)GGT>AGT	p.G41S		NM_174909	NP_777569	Q8TBQ9	KISHA_HUMAN	transmembrane protein 167A precursor	41	Extracellular (Potential).					Golgi membrane|integral to membrane					0						CAAAATATACCCAACAATCTG	0.303													9	40					0	0	0	0	T	82357723	T	T	82357723	3	4	270	1	0	0	0	0	1	0	0	0	16147	623	22	4	105	4	TMEM167A	5	82357723	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	6403350	82357723	98557537	66	48954											
C5orf36	285600	broad.mit.edu	37	chr5	93856508	93856508	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agacgtcctagagaggaaatGgaaagatgttccacttaggg	14	8	13	6	1	0	3	0	0	0	3	2	6	2	5	2	3	0	1	2	3	4	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:93856508G>T	uc011cuk.1	-	5	672	c.415C>A	c.(415-417)CAT>AAT	p.H139N	C5orf36_uc003kkp.2_Missense_Mutation_p.H139N	NM_001145678	NP_001139150	Q8IV33	K0825_HUMAN	hypothetical protein LOC285600 isoform 1	139											0		all_cancers(142;2.12e-08)|all_epithelial(76;5.95e-11)|all_lung(232;0.000996)|Lung NSC(167;0.0108)|Ovarian(174;0.0218)|Colorectal(57;0.0329)|Breast(839;0.214)|Lung SC(612;0.236)		all cancers(79;3.96e-19)		GAGAGGAAATGGAAAGATGTT	0.413													4	37					0.00024832	0.000258826	1	0	T	93856508	T	T	93856508	3	4	270	1	0	0	0	0	1	0	0	0	2305	1348	47	4	3485	4	C5orf36	5	93856508	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	11498785	93856508	87058752	67	48955											
BRD8	10902	broad.mit.edu	37	chr5	137476488	137476488	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacagcattttggaacatcAgcatcaggtctcgcaggaat	12	11	9	9	1	3	0	2	0	1	0	4	2	3	2	0	3	4	3	0	3	3	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:137476488A>G	uc003lcf.1	-	26	3576	c.3521T>C	c.(3520-3522)CTG>CCG	p.L1174P	BRD8_uc003lcc.1_Intron|NME5_uc003lce.2_5'Flank	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	1174	Bromo 2.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTGGAACATCAGCATCAGGTC	0.483													60	255					0	0	0	0	G	137476488	G	G	137476488	3	3	270	1	0	0	0	0	1	0	0	0	1511	188	7	5	194	5	BRD8	5	137476488	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	43619980	137476488	43438772	68	48956											
PCDHA8	56140	broad.mit.edu	37	chr5	140223207	140223207	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgaggggccaccgaagacGgacctcatggccttcagccc	8	5	14	14	2	2	2	2	1	0	1	2	4	2	3	5	5	1	0	5	5	1	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:140223207G>C	uc003lhs.2	+	1	2301	c.2301G>C	c.(2299-2301)ACG>ACC	p.T767T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.T767T	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	767	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCGAAGACGGACCTCATGG	0.572													12	33					0	0	0	0	C	140223207	C	C	140223207	2	2	270	1	0	0	0	0	0	0	0	1	11584	1103	39	3		3	PCDHA8	5	140223207	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	2746719	140223207	40692053	69	48957											
PCDHB12	56124	broad.mit.edu	37	chr5	140588692	140588692	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgggtggtttctaatgataaCaaagagtgtttgcagctgga	11	12	13	5	1	1	2	0	1	1	1	1	3	1	3	0	3	3	4	0	3	3	4	rs145009914		TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:140588692C>A	uc003liz.2	+	1	402	c.213C>A	c.(211-213)AAC>AAA	p.N71K	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	71	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTAATGATAACAAAGAGTGTT	0.522													31	62					2.08457e-15	2.71595e-15	1	0	A	140588692	A	A	140588692	3	1	270	1	0	0	0	0	1	0	0	0	11591	477	17	4	215	4	PCDHB12	5	140588692	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	365485	140588692	40326568	70	48958											
WWC1	23286	broad.mit.edu	37	chr5	167855056	167855056	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agctgtgaatacggcccaggGgtgtggcctgaaagtggcct	8	8	16	9	1	0	2	0	2	0	0	0	2	0	2	3	5	2	1	3	5	3	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:167855056G>T	uc003lzu.2	+	12	1922	c.1829G>T	c.(1828-1830)GGG>GTG	p.G610V	WWC1_uc003lzv.2_Missense_Mutation_p.G610V|WWC1_uc011den.1_Missense_Mutation_p.G610V|WWC1_uc003lzw.2_Missense_Mutation_p.G409V	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	610					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		ACGGCCCAGGGGTGTGGCCTG	0.512													15	31					6.31663e-08	7.25341e-08	1	0	T	167855056	T	T	167855056	3	4	270	1	0	0	0	0	1	0	0	0	17479	1232	43	4	1875	4	WWC1	5	167855056	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	27266364	167855056	13060204	71	48959											
SLIT3	6586	broad.mit.edu	37	chr5	168135107	168135107	+	Splice_Site	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgttgatgtccactggcccTgggcagcaaaaccagagtac	11	8	11	11	0	0	2	0	1	0	1	1	2	1	2	3	2	3	4	3	2	3	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:168135107T>G	uc003mab.2	-	26	3140	c.2720_splice	c.e26-1	p.G907_splice	SLIT3_uc010jjg.2_Silent_p.P913P	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor						apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCACTGGCCCTGGGCAGCAAA	0.612													5	41					0	0	0	0	G	168135107	G	G	168135107	5	3	270	1	0	0	0	0	0	0	1	0	14805	1594	55	5	1897	5	SLIT3	5	168135107	Splice_Site	SNP	T	TCGA-CV-7440-01A-11D-2129-08	280051	168135107	12780153	72	48960											
CCDC99	54908	broad.mit.edu	37	chr5	169015579	169015579	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaatgatgaccatgactgaGgtaggactctggactcctct	11	10	11	9	0	2	4	0	4	2	0	3	7	3	6	2	3	0	1	2	3	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:169015579G>C	uc003mae.3	+	2	438	c.159G>C	c.(157-159)GAG>GAC	p.E53D	CCDC99_uc010jjj.2_Intron|CCDC99_uc011deq.1_5'UTR|CCDC99_uc010jjk.2_5'UTR	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	53	Potential.				cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCATGACTGAGGTAGGACTCT	0.363													9	38					0	0	0	0	C	169015579	C	C	169015579	3	2	270	1	0	0	0	0	1	0	0	0	2889	1014	35	4	161	4	CCDC99	5	169015579	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	880472	169015579	11899681	73	48961											
CDHR2	54825	broad.mit.edu	37	chr5	176005489	176005489	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacagacggcgggaacctGtcctcctccaccacactgca	9	5	9	18	2	0	1	0	0	0	1	3	2	3	2	6	2	2	1	6	2	1	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:176005489G>A	uc003mem.1	+	16	1764	c.1698G>A	c.(1696-1698)CTG>CTA	p.L566L	CDHR2_uc003men.1_Silent_p.L566L	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	566	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GCGGGAACCTGTCCTCCTCCA	0.627													4	23					0	0	0	0	A	176005489	A	A	176005489	2	1	270	1	0	0	0	0	0	0	0	1	3134	1364	48	4		4	CDHR2	5	176005489	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	6989910	176005489	4909771	74	48962											
NSD1	64324	broad.mit.edu	37	chr5	176637776	176637776	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagttccgaagtataaagtgCaaacacaaagaaaatccagt	20	7	7	7	1	0	1	0	0	0	1	2	2	2	1	2	0	2	3	2	0	9	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:176637776C>A	uc003mfr.3	+	5	2514	c.2376C>A	c.(2374-2376)TGC>TGA	p.C792*	NSD1_uc003mft.3_Nonsense_Mutation_p.C523*|NSD1_uc003mfs.1_Nonsense_Mutation_p.C689*|NSD1_uc011dfx.1_Nonsense_Mutation_p.C440*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	792					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GTATAAAGTGCAAACACAAAG	0.428			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			11	38					0.000673444	0.000693929	1	0	A	176637776	A	A	176637776	4	1	270	1	0	0	0	0	0	1	0	0	10723	718	25	4	2390	4	NSD1	5	176637776	Nonsense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	632287	176637776	4277484	75	48963											
NSD1	64324	broad.mit.edu	37	chr5	176684042	176684042	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagttttaccatgaagagtGtgtccagaagtacccaccca	14	9	8	10	0	0	3	0	1	0	2	1	3	1	3	4	0	2	2	4	0	5	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:176684042G>C	uc003mfr.3	+	13	4994	c.4856G>C	c.(4855-4857)TGT>TCT	p.C1619S	NSD1_uc003mft.3_Missense_Mutation_p.C1350S|NSD1_uc003mfs.1_Missense_Mutation_p.C1516S|NSD1_uc011dfx.1_Missense_Mutation_p.C1267S	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1619	PHD-type 2.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CATGAAGAGTGTGTCCAGAAG	0.468			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			39	50					0	0	0	0	C	176684042	C	C	176684042	3	2	270	1	0	0	0	0	1	0	0	0	10723	1377	48	4	4902	4	NSD1	5	176684042	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	46266	176684042	4231218	76	48964											
NSD1	64324	broad.mit.edu	37	chr5	176721512	176721512	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggagaaaacctcagttccCactggcctgagacttccgcc	9	8	9	15	1	1	2	1	1	0	2	3	4	3	2	5	2	1	1	5	2	2	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr5:176721512C>A	uc003mfr.3	+	23	7281	c.7143C>A	c.(7141-7143)CCC>CCA	p.P2381P	NSD1_uc003mft.3_Silent_p.P2112P|NSD1_uc011dfx.1_Silent_p.P2029P	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2381	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CCTCAGTTCCCACTGGCCTGA	0.562			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			16	63					2.31682e-05	2.47189e-05	1	0	A	176721512	A	A	176721512	2	1	270	1	0	0	0	0	0	0	0	1	10723	581	21	4		4	NSD1	5	176721512	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	37470	176721512	4193748	77	48965											
NCR2	9436	broad.mit.edu	37	chr6	41318574	41318574	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgcaaggactaagataaGcgatgatgatgatgaacaca	16	9	11	5	1	0	5	0	4	0	1	0	7	0	6	0	1	3	2	0	1	4	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr6:41318574G>C	uc003oqh.2	+	5	890	c.803G>C	c.(802-804)AGC>ACC	p.S268T	NCR2_uc003oqi.2_3'UTR|NCR2_uc003oqj.2_3'UTR	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	268	Cytoplasmic (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					actaagataagcgatgatgat	0.129													16	34					0	0	0	0	C	41318574	C	C	41318574	3	2	270	1	0	0	0	0	1	0	0	0	10292	971	34	4	821	4	NCR2	6	41318574	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08		41318574	129796493	78	48966											
COL19A1	1310	broad.mit.edu	37	chr6	70778326	70778326	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcctcatagggttccctgggGatacaaggcccccaaggtcc	8	8	11	14	0	1	0	1	0	0	0	4	1	4	1	5	5	1	1	5	5	4	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr6:70778326G>T	uc003pfc.1	+	15	1299	c.1182G>T	c.(1180-1182)GGG>GGT	p.G394G	COL19A1_uc010kam.1_Silent_p.G290G	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	394	Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GTTCCCTGGGGATACAAGGCC	0.418													13	38					1.67942e-08	1.95231e-08	1	0	T	70778326	T	T	70778326	2	4	270	1	0	0	0	0	0	0	0	1	3691	1161	41	2		2	COL19A1	6	70778326	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	29459752	70778326	100336741	79	48967											
LIN28B	389421	broad.mit.edu	37	chr6	105474345	105474346	+	Frame_Shift_Ins	INS	-	A	A																															acactacagaaaagaaaaccINSaaagggagataggtaatcat																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr6:105474345_105474346insA	uc003pqv.1	+	3	574_575	c.371_372insA	c.(370-372)CCAfs	p.P124fs	LIN28B_uc010kda.1_Frame_Shift_Ins_p.P84fs	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	124					miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				AAAAGAAAACCAAAGGGAGATA	0.376													---	---	---								A	105474346	A	A	105474345	7	5	270	1	0	1	1	0	0	0	0	0	8848	594	21	0	381	0	LIN28B	6	105474345	Frame_Shift_Ins	INS	-	TCGA-CV-7440-01A-11D-2129-08	34696019	105474345	65640722	80	48968											
SLC35F1	222553	broad.mit.edu	37	chr6	118556735	118556735	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtacatgattttgggactcaTagacctggaagcaaattatc	13	12	9	7	0	1	2	1	1	0	1	2	4	1	4	1	2	2	2	1	2	5	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr6:118556735T>C	uc003pxx.3	+	3	614	c.413T>C	c.(412-414)ATA>ACA	p.I138T		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	138	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		TTGGGACTCATAGACCTGGAA	0.433													23	46					0	0	0	0	C	118556735	C	C	118556735	3	2	270	1	0	0	0	0	1	0	0	0	14652	1406	49	5	423	5	SLC35F1	6	118556735	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	13082390	118556735	52558332	81	48969											
FAM184A	79632	broad.mit.edu	37	chr6	119341265	119341265	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactctcgatttttctgattCtaaatctttaattgtaactt	10	20	4	7	1	4	1	0	1	4	0	5	3	4	1	0	0	1	1	0	0	4	9			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr6:119341265C>A	uc003pyj.2	-	4	1558	c.1210G>T	c.(1210-1212)GAA>TAA	p.E404*	FAM184A_uc003pyk.3_Nonsense_Mutation_p.E284*|FAM184A_uc003pyl.3_Nonsense_Mutation_p.E284*	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	404	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TTTTCTGATTCTAAATCTTTA	0.363													13	35					9.05144e-12	1.1409e-11	1	0	A	119341265	A	A	119341265	4	1	270	1	0	0	0	0	0	1	0	0	5539	922	32	2	2272	2	FAM184A	6	119341265	Nonsense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	784530	119341265	51773802	82	48970											
LAMA2	3908	broad.mit.edu	37	chr6	129674405	129674405	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcactgcctgtgccctgtgaCcctgtcacaggattctgcac	6	11	9	15	0	3	1	2	1	1	0	3	2	3	2	3	1	3	1	3	1	0	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr6:129674405C>G	uc003qbn.2	+	32	4725	c.4620C>G	c.(4618-4620)GAC>GAG	p.D1540E	LAMA2_uc003qbo.2_Missense_Mutation_p.D1540E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1540	Laminin EGF-like 17.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGCCCTGTGACCCTGTCACAG	0.602													23	50					0	0	0	0	G	129674405	G	G	129674405	3	3	270	1	0	0	0	0	1	0	0	0	8646	506	18	4	4746	4	LAMA2	6	129674405	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	10333140	129674405	41440662	83	48971											
LAMA2	3908	broad.mit.edu	37	chr6	129714275	129714275	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaatggagaaggatctccggGaaaaactggctgactacaaa	17	6	11	7	1	1	2	0	1	1	1	2	5	1	4	1	4	2	1	1	4	6	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr6:129714275G>T	uc003qbn.2	+	37	5425	c.5320G>T	c.(5320-5322)GAA>TAA	p.E1774*	LAMA2_uc003qbo.2_Nonsense_Mutation_p.E1774*	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1774	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GGATCTCCGGGAAAAACTGGC	0.448													17	47					4.7546e-09	5.62663e-09	1	0	T	129714275	T	T	129714275	4	4	270	1	0	0	0	0	0	1	0	0	8646	1175	41	2	5466	2	LAMA2	6	129714275	Nonsense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	39870	129714275	41400792	84	48972											
ENPP3	5169	broad.mit.edu	37	chr6	132039838	132039838	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atcaaatacaaattgtggagGaggcaaccatggttataaca	17	9	9	6	0	1	0	1	0	0	0	1	2	1	2	1	4	3	2	1	4	6	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr6:132039838G>A	uc003qcu.3	+	17	1786	c.1439G>A	c.(1438-1440)GGA>GAA	p.G480E	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.G480E	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	480	Extracellular (Potential).|Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		AATTGTGGAGGAGGCAACCAT	0.234													25	67					0	0	0	0	A	132039838	A	A	132039838	3	1	270	1	0	0	0	0	1	0	0	0	5155	1174	41	2	1501	2	ENPP3	6	132039838	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	2325563	132039838	39075229	85	48973											
SYNE1	23345	broad.mit.edu	37	chr6	152665276	152665276	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttggctctaaatccggctgGactgcagaaagccaggcctg	9	8	12	12	1	1	1	0	0	1	1	2	2	2	2	3	4	2	3	3	4	3	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr6:152665276G>T	uc010kiw.2	-	74	12767	c.12165C>A	c.(12163-12165)GTC>GTA	p.V4055V	SYNE1_uc003qot.3_Silent_p.V3984V|SYNE1_uc003qou.3_Silent_p.V4055V|SYNE1_uc010kja.1_Silent_p.V760V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4055	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AATCCGGCTGGACTGCAGAAA	0.478										HNSCC(10;0.0054)			42	39					3.61848e-18	4.8069e-18	1	0	T	152665276	T	T	152665276	2	4	270	1	0	0	0	0	0	0	0	1	15511	1161	41	2		2	SYNE1	6	152665276	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	20625438	152665276	18449791	86	48974											
SDK1	221935	broad.mit.edu	37	chr7	4188976	4188976	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggctccagtgggtcccgggCagcgacggggcctcccccat	4	5	15	17	4	0	0	0	0	0	0	3	1	3	0	5	5	1	2	5	5	0	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:4188976C>T	uc003smx.2	+	30	4645	c.4506C>T	c.(4504-4506)GGC>GGT	p.G1502G	SDK1_uc010kso.2_Silent_p.G778G|SDK1_uc003smy.2_5'UTR	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1502	Fibronectin type-III 9.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGGTCCCGGGCAGCGACGGGG	0.677													10	22					0	0	0	0	T	4188976	T	T	4188976	2	4	270	1	0	0	0	0	0	0	0	1	14033	697	25	4		4	SDK1	7	4188976	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08		4188976	154949687	87	48975											
SLC29A4	222962	broad.mit.edu	37	chr7	5342477	5342477	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgacgctggggtccgcCgtggcctactgcacctacag	5	7	15	14	3	0	1	0	1	0	0	1	1	1	1	4	4	3	3	4	4	2	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	e55ecf9c-0059-48ac-ba84-6879a8ec7311	g.chr7:5342477C>T	uc003sod.2	+	11	1661	c.1500C>T	c.(1498-1500)GCC>GCT	p.A500A	SLC29A4_uc003soc.2_Silent_p.A500A|SLC29A4_uc003soe.2_Silent_p.A486A|SLC29A4_uc010ksw.2_RNA	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	500	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		TGGGGTCCGCCGTGGCCTACT	0.677													3	3					0	0	0	0	T	5342477	T	T	5342477	2	4	270	1	0	0	0	0	0	0	0	1	14601	639	23	1		1	SLC29A4	7	5342477	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	1153501	5342477	153796186	88	48976											
ABCA13	154664	broad.mit.edu	37	chr7	48312325	48312325	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttaagacagcagaggttcTtgggggaatttctaatgtat	12	14	11	4	0	2	2	0	0	2	2	2	3	2	3	0	3	1	3	0	3	4	7			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:48312325T>A	uc003toq.2	+	17	3087	c.3062T>A	c.(3061-3063)CTT>CAT	p.L1021H	ABCA13_uc010kyr.2_Missense_Mutation_p.L524H	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1021					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GCAGAGGTTCTTGGGGGAATT	0.338													8	13					0	0	0	0	A	48312325	A	A	48312325	3	1	270	1	0	0	0	0	1	0	0	0	31	1609	56	5	2957	5	ABCA13	7	48312325	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	42969848	48312325	110826338	89	48977											
PCLO	27445	broad.mit.edu	37	chr7	82582945	82582945	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggagatgcaactgttaactTttttttaggaagaatagttg	12	16	10	3	0	0	2	0	0	0	2	0	4	0	3	0	2	3	3	0	2	6	7			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:82582945T>A	uc003uhx.2	-	5	7613	c.7324A>T	c.(7324-7326)AAG>TAG	p.K2442*	PCLO_uc003uhv.2_Nonsense_Mutation_p.K2442*|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2373	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACTGTTAACTTTTTTTTAGGA	0.274													3	12					0	0	0	0	A	82582945	A	A	82582945	4	1	270	1	0	0	0	0	0	1	0	0	11637	1850	64	5	8205	5	PCLO	7	82582945	Nonsense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	34270620	82582945	76555718	90	48978											
GRM3	2913	broad.mit.edu	37	chr7	86479718	86479718	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	accatgtgcatctctgtcagCctgagtggctttgtggtctt	5	15	11	10	0	3	1	1	1	2	0	4	1	3	1	2	2	2	2	2	2	0	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:86479718C>T	uc003uid.2	+	5	3523	c.2424C>T	c.(2422-2424)AGC>AGT	p.S808S	GRM3_uc010lef.2_Missense_Mutation_p.P451S|GRM3_uc010leg.2_Silent_p.S680S|GRM3_uc010leh.2_Silent_p.S400S	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	808	Helical; Name=7; (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TCTCTGTCAGCCTGAGTGGCT	0.488													17	30					0	0	0	0	T	86479718	T	T	86479718	2	4	270	1	0	0	0	0	0	0	0	1	6837	738	26	4		4	GRM3	7	86479718	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	3896773	86479718	72658945	91	48979											
TRRAP	8295	broad.mit.edu	37	chr7	98609784	98609784	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcctctcctctctcggccGccgggcagccagagaacatg	6	7	11	17	4	2	1	0	0	2	1	6	2	3	1	5	2	2	1	5	2	1	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:98609784G>T	uc003upp.2	+	72	11595	c.11386G>T	c.(11386-11388)GCC>TCC	p.A3796S	TRRAP_uc011kis.1_Missense_Mutation_p.A3767S|TRRAP_uc003upr.2_Missense_Mutation_p.A3502S|TRRAP_uc003ups.2_5'Flank	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3796	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCTCTCGGCCGCCGGGCAGCC	0.582													16	23					1.99824e-07	2.2753e-07	1	0	T	98609784	T	T	98609784	3	4	270	1	0	0	0	0	1	0	0	0	16668	1087	38	3	11577	3	TRRAP	7	98609784	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	12130066	98609784	60528879	92	48980											
GAL3ST4	79690	broad.mit.edu	37	chr7	99757693	99757693	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgggggctcaatccactcCgaagtatatagcccaaaacc	12	8	8	13	1	1	0	1	0	0	0	3	1	3	0	4	2	2	2	4	2	7	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:99757693C>A	uc003utt.2	-	3	2336	c.1319G>T	c.(1318-1320)CGG>CTG	p.R440L	C7orf43_uc010lgp.2_5'Flank|C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.R440L|GAL3ST4_uc010lgq.2_Missense_Mutation_p.R378L	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	440	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAATCCACTCCGAAGTATATA	0.557													14	67					1.05317e-09	1.27415e-09	1	0	A	99757693	A	A	99757693	3	1	270	1	0	0	0	0	1	0	0	0	6235	652	23	3	145	3	GAL3ST4	7	99757693	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	1147909	99757693	59380970	93	48981											
FBXL13	222235	broad.mit.edu	37	chr7	102604000	102604000	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgacagatctgaaagttttgGgtcggagaagacaaccacga	14	8	12	7	2	1	5	0	2	1	3	2	7	1	5	1	2	1	1	1	2	3	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:102604000G>T	uc003vaq.2	-	8	1131	c.704C>A	c.(703-705)CCC>CAC	p.P235H	FBXL13_uc010liq.1_Missense_Mutation_p.P50H|FBXL13_uc010lir.1_Missense_Mutation_p.P235H|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.P235H|FBXL13_uc003vav.2_RNA	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	235	LRR 1.										0						GAAAGTTTTGGGTCGGAGAAG	0.328													20	55					3.62473e-10	4.42479e-10	1	0	T	102604000	T	T	102604000	3	4	270	1	0	0	0	0	1	0	0	0	5741	1232	43	4	1555	4	FBXL13	7	102604000	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	2846307	102604000	56534663	94	48982											
DOCK4	9732	broad.mit.edu	37	chr7	111379256	111379256	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctcttggtgacaggcaagaGttttctcgggaatgtttgtg	7	15	13	6	1	2	2	0	1	2	1	4	3	2	3	0	3	0	3	0	3	2	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:111379256G>A	uc003vfx.2	-	48	5408	c.5139C>T	c.(5137-5139)AAC>AAT	p.N1713N	DOCK4_uc011kml.1_Silent_p.N594N|DOCK4_uc011kmm.1_Silent_p.N620N|DOCK4_uc003vfw.2_Silent_p.N1163N|DOCK4_uc003vfy.2_Silent_p.N1758N|DOCK4_uc003vfv.2_Silent_p.N26N	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1713	Ser-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				ACAGGCAAGAGTTTTCTCGGG	0.483													15	85					0	0	0	0	A	111379256	A	A	111379256	2	1	270	1	0	0	0	0	0	0	0	1	4711	1020	36	4		4	DOCK4	7	111379256	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	8775256	111379256	47759407	95	48983											
CHRM2	1129	broad.mit.edu	37	chr7	136700500	136700500	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgctgttgcctctaatatGagagatgatgaaataaccca	14	11	9	7	0	1	4	0	3	1	1	1	5	1	4	2	0	3	2	2	0	4	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:136700500G>C	uc003vtf.1	+	4	1511	c.888G>C	c.(886-888)ATG>ATC	p.M296I	CHRM2_uc003vtg.1_Missense_Mutation_p.M296I|CHRM2_uc003vtj.1_Missense_Mutation_p.M296I|CHRM2_uc003vtk.1_Missense_Mutation_p.M296I|CHRM2_uc003vtl.1_Missense_Mutation_p.M296I|CHRM2_uc003vtm.1_Missense_Mutation_p.M296I|CHRM2_uc003vti.1_Missense_Mutation_p.M296I|CHRM2_uc003vto.1_Missense_Mutation_p.M296I|CHRM2_uc003vtn.1_Missense_Mutation_p.M296I|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	296	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CCTCTAATATGAGAGATGATG	0.478													9	67					0	0	0	0	C	136700500	C	C	136700500	3	2	270	1	0	0	0	0	1	0	0	0	3392	1290	45	2	890	2	CHRM2	7	136700500	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	25321244	136700500	22438163	96	48984											
TMEM213	155006	broad.mit.edu	37	chr7	138487681	138487681	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaagcagcccggtgctgccGcacaggagtggacgagtacg	10	4	15	12	4	0	0	0	0	0	0	0	3	0	2	2	3	5	4	2	3	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:138487681G>A	uc010lna.2	+	3	302	c.191G>A	c.(190-192)CGC>CAC	p.R64H	TMEM213_uc010lnb.2_Missense_Mutation_p.R63H	NM_001085429	NP_001078898	A2RRL7	TM213_HUMAN	transmembrane protein 213	64	Extracellular (Potential).					integral to membrane					0						CGGTGCTGCCGCACAGGAGTG	0.627													19	36					0	0	0	0	A	138487681	A	A	138487681	3	1	270	1	0	0	0	0	1	0	0	0	16202	1087	38	1	201	1	TMEM213	7	138487681	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	1787181	138487681	20650982	97	48985											
EPHA1	2041	broad.mit.edu	37	chr7	143095840	143095841	+	Frame_Shift_Ins	INS	-	G	G																															tgcaggtgtggtgagcccccINSgggcccccggcgagaagtgc																								rs143087087		TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:143095840_143095841insG	uc003wcz.2	-	6	1276_1277	c.1189_1190insC	c.(1189-1191)CGGfs	p.R397fs		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	397	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GGTGAGCCCCCGGGCCCCCGGC	0.614													---	---	---								G	143095841	G	G	143095840	7	5	270	1	0	1	1	0	0	0	0	0	5189	652	23	0	1792	0	EPHA1	7	143095840	Frame_Shift_Ins	INS	-	TCGA-CV-7440-01A-11D-2129-08	4608159	143095840	16042823	98	48986											
ZNF398	57541	broad.mit.edu	37	chr7	148851047	148851047	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatgcagacatctgaatGggactccgagtgccttacat	10	10	10	11	1	1	2	0	1	1	1	2	4	2	3	2	1	4	2	2	1	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:148851047G>T	uc003wfl.2	+	2	310	c.35G>T	c.(34-36)TGG>TTG	p.W12L	ZNF398_uc011kul.1_5'UTR|ZNF398_uc011kum.1_Missense_Mutation_p.W17L	NM_170686	NP_733787	Q8TD17	ZN398_HUMAN	zinc finger 398 isoform a	12					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			ACATCTGAATGGGACTCCGAG	0.493													21	88					2.98393e-07	3.38345e-07	1	0	T	148851047	T	T	148851047	3	4	270	1	0	0	0	0	1	0	0	0	17952	1357	47	4	41	4	ZNF398	7	148851047	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	5755207	148851047	10287616	99	48987											
ZNF862	643641	broad.mit.edu	37	chr7	149545456	149545456	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaggcaaaaagaaatcactGatggcatccacagctcctca	15	7	8	11	0	2	3	2	2	0	1	4	3	4	3	2	2	1	3	2	2	3	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr7:149545456G>A	uc010lpn.2	+	4	1066	c.874G>A	c.(874-876)GAT>AAT	p.D292N	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1						AGAAATCACTGATGGCATCCA	0.403													3	14					0	0	0	0	A	149545456	A	A	149545456	3	1	270	1	0	0	0	0	1	0	0	0	18262	1290	45	2	888	2	ZNF862	7	149545456	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	694409	149545456	9593207	100	48988											
USP17L2	377630	broad.mit.edu	37	chr8	11994697	11994697	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcactggcacacaagcagagCcctcttgctgtgtttgttct	7	13	9	12	0	3	1	1	0	2	1	3	1	3	1	1	1	3	5	1	1	1	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:11994697C>A	uc003wvc.1	-	1	1573	c.1573G>T	c.(1573-1575)GCT>TCT	p.A525S	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	525					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						ACAAGCAGAGCCCTCTTGCTG	0.448													12	42					1.05317e-09	1.27415e-09	1	0	A	11994697	A	A	11994697	3	1	270	1	0	0	0	0	1	0	0	0	17116	739	26	4	23	4	USP17L2	8	11994697	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08		11994697	134369325	101	48989											
ANK1	286	broad.mit.edu	37	chr8	41572572	41572572	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcccgtacttggccgccacGtgcagaggggtaaatccttt	7	11	11	12	3	0	1	0	0	0	1	2	1	2	1	4	3	2	3	4	3	3	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:41572572G>A	uc003xok.2	-	15	1707	c.1623C>T	c.(1621-1623)CAC>CAT	p.H541H	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Silent_p.H541H|ANK1_uc003xoj.2_Silent_p.H541H|ANK1_uc003xol.2_Silent_p.H541H|ANK1_uc003xom.2_Silent_p.H574H	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	541	89 kDa domain.|ANK 16.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGGCCGCCACGTGCAGAGGGG	0.627													24	67					0	0	0	0	A	41572572	A	A	41572572	2	1	270	1	0	0	0	0	0	0	0	1	620	1136	40	1		1	ANK1	8	41572572	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	29577875	41572572	104791450	102	48990											
DCAF4L2	138009	broad.mit.edu	37	chr8	88886180	88886180	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgtctgcttcctcgagcagtCgcggtcttttgctctccatt	3	16	9	13	3	3	0	0	0	3	0	7	1	4	0	2	1	3	3	2	1	0	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:88886180C>G	uc003ydz.2	-	1	117	c.20G>C	c.(19-21)CGA>CCA	p.R7P		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	7										ovary(1)	1						CTCGAGCAGTCGCGGTCTTTT	0.522													14	34					0	0	0	0	G	88886180	G	G	88886180	3	3	270	1	0	0	0	0	1	0	0	0	4289	884	31	3	1171	3	DCAF4L2	8	88886180	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	47313608	88886180	57477842	103	48991											
RIPK2	8767	broad.mit.edu	37	chr8	90798848	90798848	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggatcctctcagctccatGaaaatagtggttctcctgaa	10	12	9	10	0	2	2	1	2	2	0	6	3	4	3	3	2	1	2	3	2	4	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:90798848G>A	uc003yee.2	+	9	1371	c.1057G>A	c.(1057-1059)GAA>AAA	p.E353K	RIPK2_uc003yef.2_Missense_Mutation_p.E216K	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	353					activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TCAGCTCCATGAAAATAGTGG	0.318													24	112					0	0	0	0	A	90798848	A	A	90798848	3	1	270	1	0	0	0	0	1	0	0	0	13446	1291	45	2	1091	2	RIPK2	8	90798848	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	1912668	90798848	55565174	104	48992											
KIAA1429	25962	broad.mit.edu	37	chr8	95538791	95538791	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttaatctctgacaagacttCatagaaatggcatttttgga	13	15	7	6	0	2	3	1	1	1	2	3	4	2	4	0	2	0	1	0	2	4	6			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:95538791C>T	uc003ygo.1	-	8	1694	c.1681G>A	c.(1681-1683)GAA>AAA	p.E561K	KIAA1429_uc003ygp.2_Missense_Mutation_p.E561K|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	561					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GACAAGACTTCATAGAAATGG	0.403													33	164					0	0	0	0	T	95538791	T	T	95538791	3	4	270	1	0	0	0	0	1	0	0	0	8270	835	29	2	3879	2	KIAA1429	8	95538791	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	4739943	95538791	50825231	105	48993											
ANKRD46	157567	broad.mit.edu	37	chr8	101541965	101541965	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atttgggtcaaagccactttCcaaaagccgcttggaataat	13	11	8	9	1	1	0	1	0	0	0	2	1	2	1	3	2	2	1	3	2	5	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:101541965C>T	uc003yjm.2	-	3	301	c.97G>A	c.(97-99)GAA>AAA	p.E33K	ANKRD46_uc003yjn.1_Missense_Mutation_p.E33K|ANKRD46_uc003yjo.1_Missense_Mutation_p.E33K|ANKRD46_uc003yjp.1_Missense_Mutation_p.E33K	NM_198401	NP_940683	Q86W74	ANR46_HUMAN	ankyrin repeat domain 46	33	ANK 1.					integral to membrane					0	all_cancers(14;5.07e-05)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000353)|all_lung(17;0.000998)		Epithelial(11;2.61e-11)|all cancers(13;5.03e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.49e-06)|STAD - Stomach adenocarcinoma(118;0.0957)			AAGCCACTTTCCAAAAGCCGC	0.453													14	90					0	0	0	0	T	101541965	T	T	101541965	3	4	270	1	0	0	0	0	1	0	0	0	674	864	30	2	601	2	ANKRD46	8	101541965	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	6003174	101541965	44822057	106	48994											
SYBU	55638	broad.mit.edu	37	chr8	110587410	110587410	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaatccagctctctcatgaGgcggtttgcatgaacttctg	10	12	9	10	1	3	2	1	2	2	0	5	2	4	2	1	2	3	3	1	2	3	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:110587410G>C	uc003ynj.3	-	7	1880	c.1717C>G	c.(1717-1719)CTC>GTC	p.L573V	SYBU_uc003yni.3_Missense_Mutation_p.L570V|SYBU_uc003ynk.3_Missense_Mutation_p.L454V|SYBU_uc010mco.2_Missense_Mutation_p.L572V|SYBU_uc003ynl.3_Missense_Mutation_p.L572V|SYBU_uc010mcp.2_Missense_Mutation_p.L573V|SYBU_uc010mcq.2_Missense_Mutation_p.L573V|SYBU_uc003yno.3_Missense_Mutation_p.L454V|SYBU_uc010mcr.2_Missense_Mutation_p.L573V|SYBU_uc003ynm.3_Missense_Mutation_p.L572V|SYBU_uc003ynn.3_Missense_Mutation_p.L572V|SYBU_uc010mcs.2_Missense_Mutation_p.L454V|SYBU_uc010mct.2_Missense_Mutation_p.L573V|SYBU_uc010mcu.2_Missense_Mutation_p.L572V|SYBU_uc003ynp.3_Missense_Mutation_p.L505V|SYBU_uc010mcv.2_Missense_Mutation_p.L573V|SYBU_uc003ynh.3_Missense_Mutation_p.L367V|SYBU_uc011lhw.1_Missense_Mutation_p.L443V	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	573						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						TCTCTCATGAGGCGGTTTGCA	0.547													12	69					0	0	0	0	C	110587410	C	C	110587410	3	2	270	1	0	0	0	0	1	0	0	0	15493	1000	35	4	278	4	SYBU	8	110587410	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	9045445	110587410	35776612	107	48995											
CSMD3	114788	broad.mit.edu	37	chr8	113256689	113256689	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactctatgttctgttccacCtgctaagaagaagccaggct	10	11	8	12	0	2	2	0	0	2	2	3	2	3	2	3	1	2	4	3	1	4	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:113256689C>A	uc003ynu.2	-	65	10495	c.10336G>T	c.(10336-10338)GGT>TGT	p.G3446C	CSMD3_uc003yns.2_Missense_Mutation_p.G2648C|CSMD3_uc003ynt.2_Missense_Mutation_p.G3406C|CSMD3_uc011lhx.1_Missense_Mutation_p.G3277C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3446	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCTGTTCCACCTGCTAAGAAG	0.428										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	75					3.41278e-10	4.18491e-10	1	0	A	113256689	A	A	113256689	3	1	270	1	0	0	0	0	1	0	0	0	3963	681	24	4	815	4	CSMD3	8	113256689	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	2669279	113256689	33107333	108	48996											
FER1L6	654463	broad.mit.edu	37	chr8	125061872	125061872	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccagaatatttgggtgccAcagtggctgctcctgttgtg	7	12	13	9	0	0	1	0	0	0	1	1	1	1	1	3	2	3	3	3	2	2	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:125061872A>G	uc003yqw.2	+	22	2955	c.2749A>G	c.(2749-2751)ACA>GCA	p.T917A	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	917	Cytoplasmic (Potential).|C2 3.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TTTGGGTGCCACAGTGGCTGC	0.473													14	49					0	0	0	0	G	125061872	G	G	125061872	3	3	270	1	0	0	0	0	1	0	0	0	5847	159	6	5	2831	5	FER1L6	8	125061872	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	11805183	125061872	21302150	109	48997											
PTP4A3	11156	broad.mit.edu	37	chr8	142437153	142437153	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcgtggctgtgcactgcGtggcgggcctgggccggtga	2	8	20	11	4	0	1	0	1	0	0	0	1	0	1	2	5	3	3	2	5	0	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:142437153G>T	uc003ywg.1	+	3	647	c.313G>T	c.(313-315)GTG>TTG	p.V105L	PTP4A3_uc003ywh.1_Missense_Mutation_p.V105L|PTP4A3_uc010met.1_Intron	NM_032611	NP_116000	O75365	TP4A3_HUMAN	protein tyrosine phosphatase type IVA, member 3	105	Tyrosine-protein phosphatase.					early endosome|plasma membrane	identical protein binding|prenylated protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(97;2.55e-15)|all_epithelial(106;1.39e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0474)			TGTGCACTGCGTGGCGGGCCT	0.682													27	147					8.53417e-09	1.0012e-08	1	0	T	142437153	T	T	142437153	3	4	270	1	0	0	0	0	1	0	0	0	12835	1145	40	3	323	3	PTP4A3	8	142437153	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	17375281	142437153	3926869	110	48998											
GPAA1	8733	broad.mit.edu	37	chr8	145140516	145140516	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacaggggctggatggcaCtgaagctggtagccctgatc	9	7	15	10	0	0	3	0	2	0	1	1	4	0	4	1	5	2	4	1	5	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr8:145140516C>A	uc003zax.2	+	11	1602	c.1492C>A	c.(1492-1494)CTG>ATG	p.L498M		NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	498	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGGATGGCACTGAAGCTGGT	0.597													30	97					4.74835e-14	6.0986e-14	1	0	A	145140516	A	A	145140516	3	1	270	1	0	0	0	0	1	0	0	0	6625	564	20	4	1534	4	GPAA1	8	145140516	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	2703363	145140516	1223506	111	48999											
TRPM3	80036	broad.mit.edu	37	chr9	73150933	73150933	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagtctcctcatggacaggCtgtcccctcggccctccggc	5	8	10	18	2	2	0	1	0	1	0	6	1	4	1	5	4	0	1	5	4	0	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr9:73150933C>A	uc004aid.2	-	25	5304	c.5060G>T	c.(5059-5061)AGC>ATC	p.S1687I	TRPM3_uc004ahu.2_Missense_Mutation_p.S1529I|TRPM3_uc004ahv.2_Missense_Mutation_p.S1489I|TRPM3_uc004ahw.2_Missense_Mutation_p.S1559I|TRPM3_uc004ahx.2_Missense_Mutation_p.S1546I|TRPM3_uc004ahy.2_Missense_Mutation_p.S1549I|TRPM3_uc004ahz.2_Missense_Mutation_p.S1536I|TRPM3_uc004aia.2_Missense_Mutation_p.S1534I|TRPM3_uc004aib.2_Missense_Mutation_p.S1524I|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1712	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CATGGACAGGCTGTCCCCTCG	0.522													40	72					2.19489e-29	3.06605e-29	1	0	A	73150933	A	A	73150933	3	1	270	1	0	0	0	0	1	0	0	0	16654	797	28	4	67	4	TRPM3	9	73150933	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08		73150933	68062498	112	49000											
C9orf79	286234	broad.mit.edu	37	chr9	90502529	90502529	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaaagtgggggagaagcccCcaacttgggaagtcaccttg	11	7	14	9	0	1	2	1	1	0	1	1	4	1	3	3	3	2	0	3	3	4	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr9:90502529C>T	uc004app.3	+	4	3162	c.3127C>T	c.(3127-3129)CCA>TCA	p.P1043S		NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	1043						integral to membrane				ovary(3)	3						GGAGAAGCCCCCAACTTGGGA	0.602													9	60					0	0	0	0	T	90502529	T	T	90502529	3	4	270	1	0	0	0	0	1	0	0	0	2509	623	22	4	3141	4	C9orf79	9	90502529	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	17351596	90502529	50710902	113	49001											
FAM75C1	441452	broad.mit.edu	37	chr9	90537073	90537073	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtaagcagttccagagggccCcgcgagggatcccatcttca	9	7	12	13	2	2	1	1	0	1	1	4	3	4	2	4	2	1	3	4	2	1	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr9:90537073C>A	uc010mqi.2	+	4	2280	c.2251C>A	c.(2251-2253)CCG>ACG	p.P751T	FAM75C1_uc004apq.3_Missense_Mutation_p.P734T	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						CCAGAGGGCCCCGCGAGGGAT	0.547													9	28					2.80697e-09	3.33636e-09	1	0	A	90537073	A	A	90537073	3	1	270	1	0	0	0	0	1	0	0	0	5655	623	22	4	2265	4	FAM75C1	9	90537073	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	34544	90537073	50676358	114	49002											
ABCA1	19	broad.mit.edu	37	chr9	107547893	107547893	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggttggaccctgctattcgTacaactattgtataaccatc	10	13	8	10	1	0	0	0	0	0	0	2	1	0	1	2	2	4	4	2	2	6	8			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr9:107547893T>C	uc004bcl.2	-	49	6742	c.6429A>G	c.(6427-6429)GTA>GTG	p.V2143V	NIPSNAP3B_uc004bcj.1_Intron	NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	2143	ABC transporter 2.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTGCTATTCGTACAACTATTG	0.428													11	63					0	0	0	0	C	107547893	C	C	107547893	2	2	270	1	0	0	0	0	0	0	0	1	28	1625	57	5		5	ABCA1	9	107547893	Silent	SNP	T	TCGA-CV-7440-01A-11D-2129-08	17010820	107547893	33665538	115	49003											
SVEP1	79987	broad.mit.edu	37	chr9	113163273	113163273	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcatcggagaatggtggcTcccaggttccatcaagctaa	11	10	10	10	1	2	1	2	0	0	1	5	2	4	1	2	4	1	3	2	4	3	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr9:113163273T>C	uc010mtz.2	-	40	10020	c.9683A>G	c.(9682-9684)GAG>GGG	p.E3228G	SVEP1_uc010mty.2_Missense_Mutation_p.E1154G	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3228	Sushi 30.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GAATGGTGGCTCCCAGGTTCC	0.368													14	29					0	0	0	0	C	113163273	C	C	113163273	3	2	270	1	0	0	0	0	1	0	0	0	15486	1551	54	5	1068	5	SVEP1	9	113163273	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	5615380	113163273	28050158	116	49004											
PAPPA	5069	broad.mit.edu	37	chr9	119097340	119097340	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agagaggggagacctacagcCctgccgagcagaggtaaggg	12	3	17	9	1	0	3	0	0	0	3	0	6	0	3	3	4	4	2	3	4	2	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr9:119097340C>A	uc004bjn.2	+	13	3979	c.3598C>A	c.(3598-3600)CCT>ACT	p.P1200T	PAPPA_uc011lxp.1_Missense_Mutation_p.P895T|PAPPA_uc011lxq.1_Missense_Mutation_p.P575T	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1200					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GACCTACAGCCCTGCCGAGCA	0.617													9	54					0.00829132	0.00844717	1	0	A	119097340	A	A	119097340	3	1	270	1	0	0	0	0	1	0	0	0	11486	623	22	4	3648	4	PAPPA	9	119097340	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	5934067	119097340	22116091	117	49005											
COL5A1	1289	broad.mit.edu	37	chr9	137704317	137704317	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgccaggacctccaggcgAgaagggtgagacaggagacg	11	5	16	9	2	0	3	0	1	0	3	1	7	1	4	3	4	1	0	3	4	1	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr9:137704317A>G	uc004cfe.2	+	47	4095	c.3713A>G	c.(3712-3714)GAG>GGG	p.E1238G		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1238	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCTCCAGGCGAGAAGGGTGAG	0.527													6	40					0	0	0	0	G	137704317	G	G	137704317	3	3	270	1	0	0	0	0	1	0	0	0	3711	304	11	5	3899	5	COL5A1	9	137704317	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	18606977	137704317	3509114	118	49006											
C10orf18	54906	broad.mit.edu	37	chr10	5789010	5789010	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaggttgaagtggactcatCatcagcctctaccaccttgg	10	10	9	12	0	4	1	3	1	1	0	4	2	4	2	3	3	2	1	3	3	2	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:5789010C>G	uc001iij.2	+	15	4251	c.3626C>G	c.(3625-3627)TCA>TGA	p.S1209*	C10orf18_uc001iik.2_Nonsense_Mutation_p.S53*	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1209										ovary(1)|central_nervous_system(1)	2						GTGGACTCATCATCAGCCTCT	0.473													19	69					0	0	0	0	G	5789010	G	G	5789010	4	3	270	1	0	0	0	0	0	1	0	0	1602	838	29	2	3672	2	C10orf18	10	5789010	Nonsense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08		5789010	129745737	119	49007											
C10orf18	54906	broad.mit.edu	37	chr10	5790610	5790610	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcaacatgtgaaacaaaGgagctattgaatgtcggggt	13	10	13	5	1	1	2	1	2	0	0	2	3	1	3	0	3	3	1	0	3	5	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:5790610G>A	uc001iij.2	+	15	5851	c.5226G>A	c.(5224-5226)AAG>AAA	p.K1742K	C10orf18_uc001iik.2_Silent_p.K586K	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1742										ovary(1)|central_nervous_system(1)	2						GTGAAACAAAGGAGCTATTGA	0.498													13	40					0	0	0	0	A	5790610	A	A	5790610	2	1	270	1	0	0	0	0	0	0	0	1	1602	991	35	4		4	C10orf18	10	5790610	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	1600	5790610	129744137	120	49008											
FBXO18	84893	broad.mit.edu	37	chr10	5953002	5953002	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctccggagacccagctccacGgtgaccatgccagatgtcac	9	6	10	16	2	1	3	1	1	0	2	3	4	3	3	5	2	2	1	5	2	0	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:5953002G>T	uc001iis.2	+	6	1217	c.1122G>T	c.(1120-1122)ACG>ACT	p.T374T	FBXO18_uc001iir.2_Silent_p.T300T|FBXO18_uc009xig.2_Silent_p.T300T|FBXO18_uc001iit.2_Silent_p.T425T	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	374					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						CCAGCTCCACGGTGACCATGC	0.582													17	96					1.33834e-09	1.60482e-09	1	0	T	5953002	T	T	5953002	2	4	270	1	0	0	0	0	0	0	0	1	5763	1103	39	3		3	FBXO18	10	5953002	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	162392	5953002	129581745	121	49009											
ITGA8	8516	broad.mit.edu	37	chr10	15646284	15646284	+	Frame_Shift_Del	DEL	C	-	-																															ttcagcttcatatgctccttCcccttcatttcttgcattta																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:15646284delC	uc001ioc.1	-	20	2041	c.2041delG	c.(2041-2043)GAAfs	p.E681fs	ITGA8_uc010qcb.1_Frame_Shift_Del_p.E666fs	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	681	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TATGCTCCTTCCCCTTCATTT	0.358													---	---	---								-	15646284	-	-	15646284	7	5	270	1	0	1	0	1	0	0	0	0	7921	864	30	0	1194	0	ITGA8	10	15646284	Frame_Shift_Del	DEL	C	TCGA-CV-7440-01A-11D-2129-08	9693282	15646284	119888463	122	49010											
PARD3	56288	broad.mit.edu	37	chr10	34690830	34690830	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacacgactgttatcctcttCtgtcccatcctcatcctaga	9	13	4	15	1	3	1	1	0	2	1	7	2	7	1	4	0	1	1	4	0	3	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:34690830C>T	uc010qej.1	-	6	730	c.730G>A	c.(730-732)GAA>AAA	p.E244K	PARD3_uc010qek.1_Missense_Mutation_p.E244K|PARD3_uc010qel.1_Missense_Mutation_p.E244K|PARD3_uc010qem.1_Missense_Mutation_p.E244K|PARD3_uc010qen.1_Missense_Mutation_p.E244K|PARD3_uc010qeo.1_Missense_Mutation_p.E244K|PARD3_uc010qep.1_Missense_Mutation_p.E200K|PARD3_uc010qeq.1_Missense_Mutation_p.E200K|PARD3_uc001ixo.1_5'UTR|PARD3_uc001ixp.1_Missense_Mutation_p.E109K|PARD3_uc001ixq.1_Missense_Mutation_p.E244K|PARD3_uc001ixr.1_Missense_Mutation_p.E244K|PARD3_uc001ixt.1_Missense_Mutation_p.E65K|PARD3_uc001ixu.1_Missense_Mutation_p.E200K	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	244					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				TTATCCTCTTCTGTCCCATCC	0.428													58	119					0	0	0	0	T	34690830	T	T	34690830	3	4	270	1	0	0	0	0	1	0	0	0	11497	922	32	2	3455	2	PARD3	10	34690830	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	19044546	34690830	100843917	123	49011											
ANKRD30A	91074	broad.mit.edu	37	chr10	37419231	37419231	+	Nonsense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaacacggctctccattaTgctgtttatagtgagatttt	9	15	9	8	1	1	1	0	1	1	1	2	2	1	1	1	2	2	4	1	2	4	6			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:37419231T>G	uc001iza.1	+	3	366	c.267T>G	c.(265-267)TAT>TAG	p.Y89*		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	145	ANK 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CTCTCCATTATGCTGTTTATA	0.433													16	32					0	0	0	0	G	37419231	G	G	37419231	4	3	270	1	0	0	0	0	0	1	0	0	658	1471	51	5	277	5	ANKRD30A	10	37419231	Nonsense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	2728401	37419231	98115516	124	49012											
ANKRD30A	91074	broad.mit.edu	37	chr10	37508037	37508037	+	Frame_Shift_Del	DEL	T	-	-																															aggaaaaggaaaataaatacTttgaggacattaagatttta																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:37508037delT	uc001iza.1	+	34	3328	c.3229delT	c.(3229-3231)TTTfs	p.F1077fs		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1133	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AAATAAATACTTTGAGGACAT	0.333													---	---	---								-	37508037	-	-	37508037	7	5	270	1	0	1	0	1	0	0	0	0	658	1609	56	0	3363	0	ANKRD30A	10	37508037	Frame_Shift_Del	DEL	T	TCGA-CV-7440-01A-11D-2129-08	88806	37508037	98026710	125	49013											
AGAP4	119016	broad.mit.edu	37	chr10	46322017	46322017	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcccacgcatgttttggatCgactgcagggccatggcctt	6	12	11	12	2	0	0	0	0	0	0	2	2	1	1	3	3	1	3	3	3	0	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:46322017C>T	uc001jcx.3	-	7	1464	c.1338G>A	c.(1336-1338)TCG>TCA	p.S446S	AGAP4_uc010qfl.1_Silent_p.S469S|AGAP4_uc001jcy.3_Silent_p.S361S|uc010qfm.1_5'Flank	NM_133446	NP_597703	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	446	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			ovary(1)	1						TGTTTTGGATCGACTGCAGGG	0.552													63	48					0	0	0	0	T	46322017	T	T	46322017	2	4	270	1	0	0	0	0	0	0	0	1	370	871	31	1		1	AGAP4	10	46322017	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	8813980	46322017	89212730	126	49014											
SLC18A3	6572	broad.mit.edu	37	chr10	50820232	50820232	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcgctcccgttccgagcgCgatgtgctgcttgatgagcc	5	9	13	14	6	0	2	0	2	0	0	2	4	2	2	3	0	4	4	3	0	0	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:50820232C>T	uc001jhw.2	+	1	1886	c.1446C>T	c.(1444-1446)CGC>CGT	p.R482R	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	482	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GTTCCGAGCGCGATGTGCTGC	0.667													40	42					0	0	0	0	T	50820232	T	T	50820232	2	4	270	1	0	0	0	0	0	0	0	1	14492	755	27	1		1	SLC18A3	10	50820232	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	4498215	50820232	84714515	127	49015											
C10orf58	84293	broad.mit.edu	37	chr10	82187100	82187100	+	Frame_Shift_Del	DEL	G	-	-																															ctccatagaaaaagttctatGgtccacaaaggcggaagatg																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:82187100delG	uc001kcc.3	+	5	584	c.424delG	c.(424-426)GGTfs	p.G142fs	C10orf58_uc001kcd.3_Frame_Shift_Del_p.G131fs|C10orf58_uc001kce.3_Frame_Shift_Del_p.G142fs|C10orf58_uc001kcf.3_Frame_Shift_Del_p.G142fs	NM_032333	NP_115709	Q9BRX8	CJ058_HUMAN	hypothetical protein LOC84293 precursor	142						extracellular region					0			Colorectal(32;0.229)			AAAGTTCTATGGTCCACAAAG	0.493													---	---	---								-	82187100	-	-	82187100	7	5	270	1	0	1	0	1	0	0	0	0	1616	1348	47	0	438	0	C10orf58	10	82187100	Frame_Shift_Del	DEL	G	TCGA-CV-7440-01A-11D-2129-08	31366868	82187100	53347647	128	49016											
ABCC2	1244	broad.mit.edu	37	chr10	101591889	101591889	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgtgaacaggtttgccggcGtaagtatctcaagaactgtc	10	12	11	8	2	1	2	1	1	1	1	3	2	1	2	1	2	3	3	1	2	5	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:101591889G>A	uc001kqf.2	+	23	3397	c.3258_splice	c.e23+1	p.G1086_splice		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),							apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTTTGCCGGCGTAAGTATCTC	0.433													10	63					0	0	0	0	A	101591889	A	A	101591889	5	1	270	1	0	0	0	0	0	0	1	0	53	1159	40	1	3349	1	ABCC2	10	101591889	Splice_Site	SNP	G	TCGA-CV-7440-01A-11D-2129-08	19404789	101591889	33942858	129	49017											
GFRA1	2674	broad.mit.edu	37	chr10	118029071	118029071	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atctgctgttaactggttcaTatggggaatcctccagcaga	10	12	10	9	0	2	1	1	0	1	1	4	2	4	2	2	3	3	4	2	3	3	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:118029071T>A	uc001lcj.2	-	4	1060	c.362A>T	c.(361-363)TAT>TTT	p.Y121F	GFRA1_uc001lci.2_Missense_Mutation_p.Y121F|GFRA1_uc009xyr.2_Missense_Mutation_p.Y121F	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	121					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		AACTGGTTCATATGGGGAATC	0.403													8	49					0	0	0	0	A	118029071	A	A	118029071	3	1	270	1	0	0	0	0	1	0	0	0	6384	1406	49	5	1067	5	GFRA1	10	118029071	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	16437182	118029071	17505676	130	49018											
DOCK1	1793	broad.mit.edu	37	chr10	129183096	129183096	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccacctcacccagcgggacGggtaccaggccaccacgcag	9	2	11	19	3	1	0	1	0	0	0	1	1	1	1	6	3	2	2	6	3	1	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr10:129183096G>C	uc001ljt.2	+	38	3851	c.3787G>C	c.(3787-3789)GGG>CGG	p.G1263R	DOCK1_uc010qun.1_Missense_Mutation_p.G1284R|DOCK1_uc009yaq.2_Missense_Mutation_p.G258R	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1263	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CCAGCGGGACGGGTACCAGGC	0.562													13	71					0	0	0	0	C	129183096	C	C	129183096	3	2	270	1	0	0	0	0	1	0	0	0	4706	1116	39	3	3937	3	DOCK1	10	129183096	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	11154025	129183096	6351651	131	49019											
UBQLNL	143630	broad.mit.edu	37	chr11	5537198	5537198	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccaagttttgggtatgcacTttgggtgcatcagaccccac	8	12	10	11	0	1	1	1	0	0	1	2	1	2	1	3	2	2	4	3	2	2	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:5537198T>A	uc001maz.3	-	1	759	c.474A>T	c.(472-474)AAA>AAT	p.K158N	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	158										large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GGGTATGCACTTTGGGTGCAT	0.507													28	49					0	0	0	0	A	5537198	A	A	5537198	3	1	270	1	0	0	0	0	1	0	0	0	16968	1606	56	5	957	5	UBQLNL	11	5537198	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08		5537198	129469318	132	49020											
OR52N4	390072	broad.mit.edu	37	chr11	5776293	5776293	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagatgttcttcacccacaCcttcacagggatggagtctg	9	10	9	13	0	4	1	2	0	2	1	4	3	4	3	3	2	0	1	3	2	0	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:5776293C>G	uc001mbu.2	+	1	371	c.323C>G	c.(322-324)ACC>AGC	p.T108S	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TTCACCCACACCTTCACAGGG	0.483													18	72					0	0	0	0	G	5776293	G	G	5776293	3	3	270	1	0	0	0	0	1	0	0	0	11183	507	18	4	325	4	OR52N4	11	5776293	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	239095	5776293	129230223	133	49021											
OR52N5	390075	broad.mit.edu	37	chr11	5799295	5799295	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatagctttactacagacatGtggtcgcagtacgtatggga	11	11	12	7	2	0	1	0	0	0	1	1	3	0	2	0	2	4	4	0	2	5	6			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:5799295G>A	uc010qzn.1	-	1	570	c.570C>T	c.(568-570)CAC>CAT	p.H190H	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		CTACAGACATGTGGTCGCAGT	0.423													4	65					0	0	0	0	A	5799295	A	A	5799295	2	1	270	1	0	0	0	0	0	0	0	1	11184	1368	48	4		4	OR52N5	11	5799295	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	23002	5799295	129207221	134	49022											
ST5	6764	broad.mit.edu	37	chr11	8737365	8737365	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgttgggtttcagggaaaGctggcgtgggggagaggacg	7	8	21	5	2	1	1	1	0	0	1	1	4	1	3	0	6	1	4	0	6	1	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:8737365G>C	uc001mgt.2	-	6	1816	c.1630C>G	c.(1630-1632)CTT>GTT	p.L544V	ST5_uc009yfr.2_Missense_Mutation_p.L124V|ST5_uc001mgu.2_Missense_Mutation_p.L124V|ST5_uc001mgv.2_Missense_Mutation_p.L544V|ST5_uc010rbq.1_RNA|ST5_uc010rbp.1_Missense_Mutation_p.L57V	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	544					positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		TTCAGGGAAAGCTGGCGTGGG	0.632													18	42					0	0	0	0	C	8737365	C	C	8737365	3	2	270	1	0	0	0	0	1	0	0	0	15286	985	34	4	1843	4	ST5	11	8737365	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	2938070	8737365	126269151	135	49023											
IPO7	10527	broad.mit.edu	37	chr11	9459832	9459832	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagatgatgatgaaaccGgtaagggattttcaatggaa	15	10	12	4	1	1	5	1	4	0	1	1	7	1	7	1	3	1	1	1	3	5	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:9459832G>A	uc001mho.2	+	22	2837	c.2695G>A	c.(2695-2697)GAG>AAG	p.E899K		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	899	Asp-rich.				interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		tgatgaAACCGGTAAGGGATT	0.234													32	33					0	0	0	0	A	9459832	A	A	9459832	3	1	270	1	0	0	0	0	1	0	0	0	7836	1130	39	1	2781	1	IPO7	11	9459832	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	722467	9459832	125546684	136	49024											
SLC6A5	9152	broad.mit.edu	37	chr11	20673889	20673889	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgacctatggctcttacCgctatcctaactggtccatg	8	12	7	14	1	1	1	0	1	1	0	3	1	3	1	5	2	2	2	5	2	4	4	rs151244472	byFrequency	TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:20673889C>T	uc001mqd.2	+	15	2398	c.2125C>T	c.(2125-2127)CGC>TGC	p.R709C	SLC6A5_uc009yic.2_Missense_Mutation_p.R474C	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	709					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	TGGCTCTTACCGCTATCCTAA	0.488													18	107					0	0	0	0	T	20673889	T	T	20673889	3	4	270	1	0	0	0	0	1	0	0	0	14751	652	23	1	2183	1	SLC6A5	11	20673889	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	11214057	20673889	114332627	137	49025											
DCDC1	341019	broad.mit.edu	37	chr11	31327197	31327197	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atggatttaaaaagggctctCccgttgaaacataaacatcg	15	10	8	8	2	1	1	0	1	1	0	3	2	1	2	1	2	2	2	1	2	6	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:31327197C>A	uc001msv.2	-	6	921	c.719G>T	c.(718-720)GGA>GTA	p.G240V	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	240	Doublecortin.				intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					AAAGGGCTCTCCCGTTGAAAC	0.413													31	69					6.05902e-23	8.2929e-23	1	0	A	31327197	A	A	31327197	3	1	270	1	0	0	0	0	1	0	0	0	4301	855	30	2	361	2	DCDC1	11	31327197	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	10653308	31327197	103679319	138	49026											
OR5W2	390148	broad.mit.edu	37	chr11	55681277	55681277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaataggaagaacttggcCggaaatacataaagagcaga	19	5	12	5	1	0	4	0	0	0	4	0	7	0	6	1	3	3	1	1	3	8	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:55681277C>T	uc010rir.1	-	1	782	c.782G>A	c.(781-783)CGG>CAG	p.R261Q		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R261W(1)		ovary(1)|skin(1)	2						AGAACTTGGCCGGAAATACAT	0.443													6	69					0	0	0	0	T	55681277	T	T	55681277	3	4	270	1	0	0	0	0	1	0	0	0	11239	652	23	1	152	1	OR5W2	11	55681277	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	24354080	55681277	79325239	139	49027											
OR5B3	441608	broad.mit.edu	37	chr11	58170004	58170004	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaatgcactcttcacttcCttgttcctcagactatagac	9	15	5	12	0	3	3	2	1	1	2	5	3	5	3	2	0	1	2	2	0	3	7			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:58170004C>G	uc010rkf.1	-	1	879	c.879G>C	c.(877-879)AAG>AAC	p.K293N		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TCTTCACTTCCTTGTTCCTCA	0.438													6	94					0	0	0	0	G	58170004	G	G	58170004	3	3	270	1	0	0	0	0	1	0	0	0	11206	680	24	4	67	4	OR5B3	11	58170004	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	2488727	58170004	76836512	140	49028											
TMEM132A	54972	broad.mit.edu	37	chr11	60699222	60699222	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggagaatagcactggtgggGgcgtagcggtcactcgcccc	7	7	16	11	3	1	1	1	0	0	1	2	2	1	1	2	5	2	2	2	5	3	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:60699222G>T	uc001nqj.2	+	6	1271	c.1078G>T	c.(1078-1080)GGC>TGC	p.G360C	TMEM132A_uc001nqi.2_Missense_Mutation_p.G361C|TMEM132A_uc001nqk.2_Missense_Mutation_p.G373C|TMEM132A_uc001nql.1_Missense_Mutation_p.G373C|TMEM132A_uc001nqm.2_5'Flank	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	360	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CACTGGTGGGGGCGTAGCGGT	0.567													27	131					1.68575e-08	1.95231e-08	1	0	T	60699222	T	T	60699222	3	4	270	1	0	0	0	0	1	0	0	0	16111	1232	43	4	1103	4	TMEM132A	11	60699222	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	2529218	60699222	74307294	141	49029											
AHNAK	79026	broad.mit.edu	37	chr11	62289123	62289123	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtcaggcatggagatctTgggggctttgatgttcatct	9	13	13	6	0	4	2	2	1	2	1	4	3	4	2	0	4	0	3	0	4	1	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:62289123T>C	uc001ntl.2	-	5	13066	c.12766A>G	c.(12766-12768)AAG>GAG	p.K4256E	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4256					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATGGAGATCTTGGGGGCTTTG	0.478													61	327					0	0	0	0	C	62289123	C	C	62289123	3	2	270	1	0	0	0	0	1	0	0	0	414	1821	63	5	5026	5	AHNAK	11	62289123	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	1589901	62289123	72717393	142	49030											
IGHMBP2	3508	broad.mit.edu	37	chr11	68675796	68675796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caatgatgtcacttacaggcGactgaaaaagtaagtggatg	15	9	11	6	1	1	2	1	2	0	0	1	4	1	3	0	2	1	1	0	2	5	2	rs138448914	byFrequency	TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:68675796G>A	uc001ook.1	+	3	542	c.440G>A	c.(439-441)CGA>CAA	p.R147Q	IGHMBP2_uc001ooj.1_RNA	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	147					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ACTTACAGGCGACTGAAAAAG	0.453													44	57					0	0	0	0	A	68675796	A	A	68675796	3	1	270	1	0	0	0	0	1	0	0	0	7630	1058	37	1	450	1	IGHMBP2	11	68675796	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	6386673	68675796	66330720	143	49031											
PAAF1	80227	broad.mit.edu	37	chr11	73620473	73620473	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atacagccatcgttgatcggGggaggaatgtggtgtctgct	8	11	15	7	2	1	1	0	1	1	0	3	3	1	3	1	4	3	2	1	4	2	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:73620473G>A	uc001ouk.1	+	7	596	c.562G>A	c.(562-564)GGG>AGG	p.G188R	PAAF1_uc001oul.1_Missense_Mutation_p.G171R|PAAF1_uc009ytx.1_RNA|PAAF1_uc001oum.1_Missense_Mutation_p.G171R	NM_025155	NP_079431	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	188	WD 3.				interspecies interaction between organisms	proteasome complex	protein binding			ovary(1)|skin(1)	2	Breast(11;7.42e-05)					CGTTGATCGGGGGAGGAATGT	0.507													12	85					0	0	0	0	A	73620473	A	A	73620473	3	1	270	1	0	0	0	0	1	0	0	0	11416	1232	43	4	588	4	PAAF1	11	73620473	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	4944677	73620473	61386043	144	49032											
MMP13	4322	broad.mit.edu	37	chr11	102825316	102825316	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacttcagaatgagtcatatCaggggtgtaattcacaattc	13	12	9	7	0	4	2	4	1	0	1	5	3	4	2	0	2	0	1	0	2	4	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:102825316C>G	uc001phl.2	-	3	410	c.382G>C	c.(382-384)GAT>CAT	p.D128H		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	128					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TGAGTCATATCAGGGGTGTAA	0.348													12	79					0	0	0	0	G	102825316	G	G	102825316	3	3	270	1	0	0	0	0	1	0	0	0	9705	826	29	2	1065	2	MMP13	11	102825316	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	29204843	102825316	32181200	145	49033											
C11orf52	91894	broad.mit.edu	37	chr11	111796827	111796827	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtccccatgcccgggaagtGaaacacgtgcatttagaaaa	13	7	10	11	3	0	2	0	1	0	1	1	3	1	3	3	1	3	1	3	1	5	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:111796827G>T	uc001pmh.2	+	5	759	c.276G>T	c.(274-276)GTG>GTT	p.V92V	C11orf52_uc001pmi.2_Silent_p.V92V	NM_080659	NP_542390	Q96A22	CK052_HUMAN	hypothetical protein LOC91894	92										ovary(1)	1		all_cancers(61;8.8e-15)|all_epithelial(67;6.27e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.63e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.7e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0512)		CCCGGGAAGTGAAACACGTGC	0.552													7	49					8.12818e-05	8.57096e-05	1	0	T	111796827	T	T	111796827	2	4	270	1	0	0	0	0	0	0	0	1	1653	1277	45	2		2	C11orf52	11	111796827	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	8971511	111796827	23209689	146	49034											
NCAM1	4684	broad.mit.edu	37	chr11	113105876	113105876	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcggcctccgagttcaagacGcagccagtccgtaagtaaag	11	6	12	12	4	1	1	1	0	0	1	3	2	3	1	4	1	1	4	4	1	4	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:113105876G>A	uc009yyq.1	+	15	2233	c.1539G>A	c.(1537-1539)ACG>ACA	p.T513T		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	605	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AGTTCAAGACGCAGCCAGTCC	0.622													5	17					0	0	0	0	A	113105876	A	A	113105876	2	1	270	1	0	0	0	0	0	0	0	1	10256	1074	38	1		1	NCAM1	11	113105876	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	1309049	113105876	21900640	147	49035											
TECTA	7007	broad.mit.edu	37	chr11	120984288	120984288	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaatggtggaaacctcacCaatttcttcagcctcccggg	9	12	8	12	1	3	0	2	0	1	0	4	1	4	1	4	3	2	0	4	3	3	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:120984288C>T	uc010rzo.1	+	5	651	c.651C>T	c.(649-651)ACC>ACT	p.T217T		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	217	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GAAACCTCACCAATTTCTTCA	0.468													10	53					0	0	0	0	T	120984288	T	T	120984288	2	4	270	1	0	0	0	0	0	0	0	1	15813	581	21	4		4	TECTA	11	120984288	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	7878412	120984288	14022228	148	49036											
OR8G2	26492	broad.mit.edu	37	chr11	124096236	124096236	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagccatcatctgtcagctCcatggaccaggggaaagtgt	10	8	12	11	0	3	0	2	0	1	0	4	2	4	2	3	3	2	2	3	3	1	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr11:124096236C>A	uc010saf.1	+	1	839	c.839C>A	c.(838-840)TCC>TAC	p.S280Y		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	280						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TCTGTCAGCTCCATGGACCAG	0.478													22	100					1.64293e-13	2.10017e-13	1	0	A	124096236	A	A	124096236	3	1	270	1	0	0	0	0	1	0	0	0	11289	855	30	2	841	2	OR8G2	11	124096236	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	3111948	124096236	10910280	149	49037											
ITPR2	3709	broad.mit.edu	37	chr12	26818845	26818845	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacatgaaaaaattcacctGtgccagtatgttttgttccc	11	14	7	9	0	1	1	1	1	0	0	2	1	2	1	3	0	2	4	3	0	5	6			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:26818845G>A	uc001rhg.2	-	14	1966	c.1549C>T	c.(1549-1551)CAG>TAG	p.Q517*		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	517	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AAATTCACCTGTGCCAGTATG	0.303													21	50					0	0	0	0	A	26818845	A	A	26818845	4	1	270	1	0	0	0	0	0	1	0	0	7960	1386	48	4	6732	4	ITPR2	12	26818845	Nonsense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08		26818845	107033050	150	49038											
C12orf40	283461	broad.mit.edu	37	chr12	40076610	40076610	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcctaaccttctatcagagaAttgtgactcttttgttagtc	9	17	6	9	0	3	2	1	1	2	1	5	3	4	2	2	0	1	1	2	0	4	7			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:40076610A>C	uc001rmc.2	+	8	1051	c.884A>C	c.(883-885)AAT>ACT	p.N295T	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	295										ovary(6)	6						CTATCAGAGAATTGTGACTCT	0.318													34	81					0	0	0	0	C	40076610	C	C	40076610	3	2	270	1	0	0	0	0	1	0	0	0	1692	101	4	5	914	5	C12orf40	12	40076610	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	13257765	40076610	93775285	151	49039											
ESPL1	9700	broad.mit.edu	37	chr12	53676136	53676136	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtacttgctgcgtgtccAggtcctgcagctggtggcag	4	12	15	10	1	0	0	0	0	0	0	2	0	2	0	2	4	5	5	2	4	1	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:53676136A>T	uc001sck.2	+	14	2799	c.2708A>T	c.(2707-2709)CAG>CTG	p.Q903L	ESPL1_uc001scj.2_Missense_Mutation_p.Q578L|ESPL1_uc010soe.1_Missense_Mutation_p.Q114L	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	903					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CTGCGTGTCCAGGTCCTGCAG	0.577													43	90					0	0	0	0	T	53676136	T	T	53676136	3	4	270	1	0	0	0	0	1	0	0	0	5277	188	7	5	2758	5	ESPL1	12	53676136	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	13599526	53676136	80175759	152	49040											
OR10A7	121364	broad.mit.edu	37	chr12	55615024	55615024	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgtcacttcttgaagtatgTttcaccttggttatggtgcc	6	17	9	9	0	3	1	2	1	1	0	3	1	3	1	2	2	1	3	2	2	3	6			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:55615024T>C	uc010spf.1	+	1	216	c.216T>C	c.(214-216)TGT>TGC	p.C72C		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						TTGAAGTATGTTTCACCTTGG	0.408													50	171					0	0	0	0	C	55615024	C	C	55615024	2	2	270	1	0	0	0	0	0	0	0	1	10949	1731	60	5		5	OR10A7	12	55615024	Silent	SNP	T	TCGA-CV-7440-01A-11D-2129-08	1938888	55615024	78236871	153	49041											
ERBB3	2065	broad.mit.edu	37	chr12	56490314	56490319	+	In_Frame_Del	DEL	AAGGCT	-	-																															agcctctggaccccagtgagAaggctaacaaagtcttggcc																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:56490314_56490319delAAGGCT	uc001sjh.2	+	18	2276_2281	c.2083_2088delAAGGCT	c.(2083-2088)AAGGCTdel	p.KA695del	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_In_Frame_Del_p.KA52del|ERBB3_uc010sqc.1_In_Frame_Del_p.KA636del|ERBB3_uc009zok.2_Splice_Site_p.K137_splice|ERBB3_uc001sjk.2_5'UTR	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	695_696	Cytoplasmic (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CCCCAGTGAGAAGGCTAACAAAGTCT	0.51													---	---	---								-	56490319	-	-	56490314	7	5	270	1	0	1	0	1	0	0	0	0	5232	247	9	0	2284	0	ERBB3	12	56490314	In_Frame_Del	DEL	AAGGCT	TCGA-CV-7440-01A-11D-2129-08	875290	56490314	77361581	154	49042											
PTPRB	5787	broad.mit.edu	37	chr12	70954538	70954538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccttccaggaacaaggcCttgaaaccgccactccgtca	10	8	7	16	2	1	1	1	1	0	0	4	2	4	2	6	2	2	0	6	2	3	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:70954538C>T	uc001swb.3	-	15	3721	c.3691G>A	c.(3691-3693)GGC>AGC	p.G1231S	PTPRB_uc010sto.1_Missense_Mutation_p.G1141S|PTPRB_uc010stp.1_Missense_Mutation_p.G1141S|PTPRB_uc001swc.3_Missense_Mutation_p.G1449S|PTPRB_uc001swa.3_Missense_Mutation_p.G1361S|PTPRB_uc001swd.3_Missense_Mutation_p.G1448S|PTPRB_uc009zrr.1_Missense_Mutation_p.G1328S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1231	Fibronectin type-III 14.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGAACAAGGCCTTGAAACCGC	0.493													15	47					0	0	0	0	T	70954538	T	T	70954538	3	4	270	1	0	0	0	0	1	0	0	0	12861	681	24	4	2374	4	PTPRB	12	70954538	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	14464224	70954538	62897357	155	49043											
LIN7A	8825	broad.mit.edu	37	chr12	81331469	81331469	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcaatgtcgccatgtctgcCgtgggagccgaagtgacgct	7	9	14	11	4	2	1	1	1	1	0	3	3	2	2	3	1	2	1	3	1	2	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:81331469C>A	uc001szj.1	-	1	226	c.33G>T	c.(31-33)ACG>ACT	p.T11T	LIN7A_uc001szk.1_RNA|MIR618_hsa-mir-618|MI0003632_5'Flank	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	11					exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						CCATGTCTGCCGTGGGAGCCG	0.498													6	13					0.00198382	0.00203642	1	0	A	81331469	A	A	81331469	2	1	270	1	0	0	0	0	0	0	0	1	8852	639	23	3		3	LIN7A	12	81331469	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	10376931	81331469	52520426	156	49044											
EEA1	8411	broad.mit.edu	37	chr12	93221688	93221688	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aattgaaaatgctagcttacCtgctcttctaaccgagaaag	14	11	7	9	1	2	2	0	1	2	1	2	3	2	2	2	0	5	3	2	0	7	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:93221688C>A	uc001tck.2	-	12	1669	c.1404G>T	c.(1402-1404)CAG>CAT	p.Q468H		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	468	Gln/Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						GCTAGCTTACCTGCTCTTCTA	0.348													43	129					1.00953e-15	1.32165e-15	1	0	A	93221688	A	A	93221688	3	1	270	1	0	0	0	0	1	0	0	0	4943	695	24	4	2903	4	EEA1	12	93221688	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	11890219	93221688	40630207	157	49045											
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100441774	100441774	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttcattggcattactgttgCaacagtttcatcttccaaaa	11	15	5	10	0	3	0	2	0	1	0	4	0	4	0	1	1	3	4	1	1	4	6			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:100441774C>A	uc001tgq.2	-	18	4148	c.3919G>T	c.(3919-3921)GCA>TCA	p.A1307S	UHRF1BP1L_uc001tgp.2_Missense_Mutation_p.A957S	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	1307										ovary(2)	2						ATTACTGTTGCAACAGTTTCA	0.269													11	15					1.58986e-06	1.75858e-06	1	0	A	100441774	A	A	100441774	3	1	270	1	0	0	0	0	1	0	0	0	17037	710	25	4	491	4	UHRF1BP1L	12	100441774	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	7220086	100441774	33410121	158	49046											
TDG	6996	broad.mit.edu	37	chr12	104373699	104373699	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgttgagtcaaaaaaatctgGcaagtctgcaaaatcaaaag	18	9	8	6	0	4	1	2	1	2	0	4	1	4	1	0	1	1	3	0	1	8	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:104373699G>T	uc001tkg.2	+	3	480	c.257G>T	c.(256-258)GGC>GTC	p.G86V	TDG_uc010swh.1_Missense_Mutation_p.G86V|TDG_uc009zuk.2_Missense_Mutation_p.G82V|TDG_uc010swi.1_5'UTR|TDG_uc010swj.1_5'UTR	NM_003211	NP_003202	Q13569	TDG_HUMAN	thymine-DNA glycosylase	86					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			ovary(3)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(302;0.00114)		AAAAAATCTGGCAAGTCTGCA	0.338								BER_DNA_glycosylases					14	79					1.52009e-12	1.92498e-12	1	0	T	104373699	T	T	104373699	3	4	270	1	0	0	0	0	1	0	0	0	15791	1203	42	4	267	4	TDG	12	104373699	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	3931925	104373699	29478196	159	49047											
TCTN1	79600	broad.mit.edu	37	chr12	111078896	111078896	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgatctctcattcgttctggGgacagttagcagcgtagtgg	7	13	13	8	2	3	1	1	1	2	0	5	2	3	2	0	3	2	4	0	3	2	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:111078896G>T	uc009zvs.2	+	9	1154	c.1046G>T	c.(1045-1047)GGG>GTG	p.G349V	TCTN1_uc009zvr.1_RNA|TCTN1_uc001trl.2_RNA|TCTN1_uc001trm.2_Missense_Mutation_p.G289V|TCTN1_uc010syc.1_RNA|TCTN1_uc001tro.2_RNA|TCTN1_uc001trp.3_Missense_Mutation_p.G335V|TCTN1_uc001trn.3_Missense_Mutation_p.G349V|TCTN1_uc001trj.1_Missense_Mutation_p.G293V|TCTN1_uc001trk.3_RNA|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	349					multicellular organismal development	extracellular region					0						TTCGTTCTGGGGACAGTTAGC	0.393													47	101					2.52991e-16	3.34441e-16	1	0	T	111078896	T	T	111078896	3	4	270	1	0	0	0	0	1	0	0	0	15788	1232	43	4	1252	4	TCTN1	12	111078896	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	6705197	111078896	22772999	160	49048											
MAP1LC3B2	643246	broad.mit.edu	37	chr12	117013751	117013751	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcccagatccccacaccatgCcgtcggagaagaccttcaag	11	5	9	16	2	1	3	1	0	0	3	3	4	2	3	6	1	1	0	6	1	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr12:117013751C>T	uc009zwk.1	+	2	158	c.4C>T	c.(4-6)CCG>TCG	p.P2S		NM_001085481	NP_001078950	A6NCE7	MP3B2_HUMAN	microtubule-associated protein 1 light chain 3	2					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule					0						CCACACCATGCCGTCGGAGAA	0.617													33	29					0	0	0	0	T	117013751	T	T	117013751	3	4	270	1	0	0	0	0	1	0	0	0	9285	739	26	4	6	4	MAP1LC3B2	12	117013751	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	5934855	117013751	16838144	161	49049											
PDX1	3651	broad.mit.edu	37	chr13	28498541	28498541	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggctgtcatgttgaacttGaccgagagacacatcaagat	12	10	10	9	1	2	4	2	2	0	2	2	6	2	4	1	1	1	2	1	1	2	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr13:28498541G>C	uc001urt.2	+	2	663	c.555G>C	c.(553-555)TTG>TTC	p.L185F	uc001urs.1_5'Flank	NM_000209	NP_000200	P52945	PDX1_HUMAN	pancreatic and duodenal homeobox 1	185	Homeobox.				detection of glucose|generation of precursor metabolites and energy|insulin secretion|nitric oxide mediated signal transduction|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|type B pancreatic cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0	all_cancers(110;0.175)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		TGTTGAACTTGACCGAGAGAC	0.587													5	71					0	0	0	0	C	28498541	C	C	28498541	3	2	270	1	0	0	0	0	1	0	0	0	11749	1281	45	2	561	2	PDX1	13	28498541	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08		28498541	86671337	162	49050											
LHFP	10186	broad.mit.edu	37	chr13	39952615	39952615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtctgccggacttcctcaCtgtcccagcccaaggggtag	8	8	11	14	1	2	0	1	0	1	0	4	1	4	1	4	3	2	1	4	3	3	2	rs142526688	by1000genomes	TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr13:39952615C>T	uc001uxf.2	-	3	945	c.434G>A	c.(433-435)AGT>AAT	p.S145N		NM_005780	NP_005771	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner precursor	145						integral to membrane	DNA binding		HMGA2/LHFP(2)	soft_tissue(2)|lung(1)|breast(1)	4		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		GACTTCCTCACTGTCCCAGCC	0.502			T	HMGA2	lipoma								10	47					0	0	0	0	T	39952615	T	T	39952615	3	4	270	1	0	0	0	0	1	0	0	0	8804	565	20	4	176	4	LHFP	13	39952615	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	11454074	39952615	75217263	163	49051											
FAM155A	728215	broad.mit.edu	37	chr13	108518775	108518775	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttggcctcggcgcagaacCacaagtgatcagagagcagg	11	5	14	11	2	1	3	1	1	0	2	2	4	1	3	2	3	2	3	2	3	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr13:108518775C>A	uc001vql.2	-	1	686	c.170G>T	c.(169-171)TGG>TTG	p.W57L		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	57	Helical; (Potential).					integral to membrane	binding			skin(1)	1						GGCGCAGAACCACAAGTGATC	0.398													75	74					1.23106e-19	1.66808e-19	1	0	A	108518775	A	A	108518775	3	1	270	1	0	0	0	0	1	0	0	0	5493	595	21	4	1218	4	FAM155A	13	108518775	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	68566160	108518775	6651103	164	49052											
COL4A1	1282	broad.mit.edu	37	chr13	110833680	110833680	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttcccaggtaagccattaaAtcccgggcgacctggagtcc	9	8	11	13	2	0	0	0	0	0	0	3	2	3	1	5	3	1	2	5	3	3	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr13:110833680A>G	uc001vqw.3	-	29	2274	c.2152T>C	c.(2152-2154)TTT>CTT	p.F718L	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	718	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AAGCCATTAAATCCCGGGCGA	0.502													7	45					0	0	0	0	G	110833680	G	G	110833680	3	3	270	1	0	0	0	0	1	0	0	0	3704	101	4	5	2953	5	COL4A1	13	110833680	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	2314905	110833680	4336198	165	49053											
OR4N2	390429	broad.mit.edu	37	chr14	20296501	20296501	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggaagtgaaagcttccatGaaaaaggtgtttaataagca	17	9	10	5	0	0	2	0	2	0	0	1	3	1	3	1	2	2	3	1	2	6	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr14:20296501G>T	uc010tkv.1	+	1	894	c.894G>T	c.(892-894)ATG>ATT	p.M298I		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAGCTTCCATGAAAAAGGTGT	0.353													14	28					1.5842e-08	1.85051e-08	1	0	T	20296501	T	T	20296501	3	4	270	1	0	0	0	0	1	0	0	0	11131	1290	45	2	896	2	OR4N2	14	20296501	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08		20296501	87053039	166	49054											
ADCY4	196883	broad.mit.edu	37	chr14	24788954	24788954	+	Frame_Shift_Del	DEL	A	-	-																															cttggaattttcacctcatcAaaatcagcaattatctcatt																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr14:24788954delA	uc001wov.2	-	21	2733	c.2727delT	c.(2725-2727)TTTfs	p.F909fs	ADCY4_uc001wow.2_Frame_Shift_Del_p.F909fs|ADCY4_uc010toh.1_Frame_Shift_Del_p.F595fs|ADCY4_uc001wox.2_Frame_Shift_Del_p.F909fs|ADCY4_uc001woy.2_Frame_Shift_Del_p.F909fs	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	909	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		TCACCTCATCAAAATCAGCAA	0.453													---	---	---								-	24788954	-	-	24788954	7	5	270	1	0	1	0	1	0	0	0	0	296	127	5	0	526	0	ADCY4	14	24788954	Frame_Shift_Del	DEL	A	TCGA-CV-7440-01A-11D-2129-08	4492453	24788954	82560586	167	49055											
LRFN5	145581	broad.mit.edu	37	chr14	42361015	42361015	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaaaagaaagactggcacaAagccaagtacagaaccacag	21	2	9	9	0	0	4	0	0	0	4	0	4	0	4	2	1	3	2	2	1	7	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr14:42361015A>G	uc001wvm.2	+	4	3146	c.1948A>G	c.(1948-1950)AAG>GAG	p.K650E	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	650	Cytoplasmic (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GACTGGCACAAAGCCAAGTAC	0.478										HNSCC(30;0.082)			12	26					0	0	0	0	G	42361015	G	G	42361015	3	3	270	1	0	0	0	0	1	0	0	0	8991	15	1	5	1954	5	LRFN5	14	42361015	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	17572061	42361015	64988525	168	49056											
TMX1	81542	broad.mit.edu	37	chr14	51713848	51713858	+	Frame_Shift_Del	DEL	GGACTAAGAAG	-	-																															taggcgctatcagggtccaaGgactaagaaggacttcataa																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr14:51713848_51713858delGGACTAAGAAG	uc001wza.3	+	4	478_488	c.353_363delGGACTAAGAAG	c.(352-363)AGGACTAAGAAGfs	p.R118fs	TMX1_uc010aoa.2_Frame_Shift_Del_p.R34fs	NM_030755	NP_110382	Q9H3N1	TMX1_HUMAN	thioredoxin domain containing 1 precursor	118_121	Thioredoxin.|Extracellular (Potential).				anti-apoptosis|cell proliferation|cell redox homeostasis|DNA replication|electron transport chain|ER to Golgi vesicle-mediated transport|leukocyte activation|positive regulation of growth|positive regulation of transcription, DNA-dependent|response to stress|signal transduction	endoplasmic reticulum membrane|integral to membrane|membrane fraction	arsenate reductase (thioredoxin) activity|disulfide oxidoreductase activity				0						CAGGGTCCAAGGACTAAGAAGGACTTCATAA	0.351													---	---	---								-	51713858	-	-	51713848	7	5	270	1	0	1	0	1	0	0	0	0	16332	1000	35	0	367	0	TMX1	14	51713848	Frame_Shift_Del	DEL	GGACTAAGAAG	TCGA-CV-7440-01A-11D-2129-08	9352833	51713848	55635692	169	49057											
DACT1	51339	broad.mit.edu	37	chr14	59112625	59112625	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatcaaaggccgaacaagcCgaaagcaagagggtgcccct	15	3	12	11	2	1	1	1	0	0	1	1	4	1	1	4	2	4	1	4	2	6	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr14:59112625C>A	uc001xdw.2	+	4	1448	c.1284C>A	c.(1282-1284)GCC>GCA	p.A428A	DACT1_uc010trv.1_Silent_p.A147A|DACT1_uc001xdx.2_Silent_p.A391A|DACT1_uc010trw.1_Silent_p.A147A	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	428					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CCGAACAAGCCGAAAGCAAGA	0.597													7	46					5.18039e-06	5.59317e-06	1	0	A	59112625	A	A	59112625	2	1	270	1	0	0	0	0	0	0	0	1	4239	639	23	3		3	DACT1	14	59112625	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	7398777	59112625	48236915	170	49058											
JDP2	122953	broad.mit.edu	37	chr14	75936093	75936093	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgatgctgaaccgacaccGccccacctgcatcgtccgga	8	6	9	18	4	0	2	0	2	0	0	2	4	1	3	7	1	3	2	7	1	1	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr14:75936093G>A	uc010asj.2	+	4	474	c.407G>A	c.(406-408)CGC>CAC	p.R136H	JDP2_uc010tvb.1_Missense_Mutation_p.R136H|JDP2_uc010tvc.1_Missense_Mutation_p.R136H|JDP2_uc001xrq.2_Missense_Mutation_p.R147H	NM_001135047	NP_001128519	Q8WYK2	JDP2_HUMAN	Jun dimerization protein 2 isoform a	136						nucleus	sequence-specific DNA binding				0				BRCA - Breast invasive adenocarcinoma(234;0.0296)		AACCGACACCGCCCCACCTGC	0.587													17	40					0	0	0	0	A	75936093	A	A	75936093	3	1	270	1	0	0	0	0	1	0	0	0	7986	1087	38	1	454	1	JDP2	14	75936093	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	16823468	75936093	31413447	171	49059											
KIAA1409	57578	broad.mit.edu	37	chr14	94088414	94088414	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatctgatagatctatcctCagattcaacctcggggcctg	10	11	9	11	1	4	4	2	1	2	3	6	4	5	4	3	2	1	0	3	2	3	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr14:94088414C>G	uc001ybv.1	+	28	4453	c.4370C>G	c.(4369-4371)TCA>TGA	p.S1457*	KIAA1409_uc001ybs.1_Nonsense_Mutation_p.S1435*	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1612						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GATCTATCCTCAGATTCAACC	0.468													36	97					0	0	0	0	G	94088414	G	G	94088414	4	3	270	1	0	0	0	0	0	1	0	0	8269	838	29	2	4410	2	KIAA1409	14	94088414	Nonsense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	18152321	94088414	13261126	172	49060											
C14orf49	161176	broad.mit.edu	37	chr14	95922000	95922000	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggtgttccgaatgacacccGcagactgctcctccagcgtc	8	8	10	15	3	0	2	0	1	0	1	4	3	3	2	4	1	2	3	4	1	1	1	rs143391386		TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr14:95922000G>T	uc001yei.3	-	5	866	c.851C>A	c.(850-852)GCG>GAG	p.A284E	C14orf49_uc010avi.2_Missense_Mutation_p.A284E|C14orf49_uc001yej.1_Missense_Mutation_p.A284E	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	284	Spectrin 1.|Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		AATGACACCCGCAGACTGCTC	0.567													20	181					3.8784e-16	5.10217e-16	1	0	T	95922000	T	T	95922000	3	4	270	1	0	0	0	0	1	0	0	0	1782	1087	38	3	2128	3	C14orf49	14	95922000	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	1833586	95922000	11427540	173	49061											
SNRPN	6638	broad.mit.edu	37	chr15	25221556	25221556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gactgtggaggggccaccccCcaaagatgtaaggaagatgt	12	6	14	9	0	0	2	0	0	0	2	0	5	0	4	4	4	0	1	4	4	3	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr15:25221556C>T	uc001ywp.1	+	9	1150	c.260C>T	c.(259-261)CCC>CTC	p.P87L	SNRPN_uc001ywq.1_Missense_Mutation_p.P87L|SNRPN_uc001ywr.1_Missense_Mutation_p.P87L|SNRPN_uc001yws.1_Missense_Mutation_p.P87L|SNRPN_uc001ywt.1_Missense_Mutation_p.P87L|SNRPN_uc001ywv.1_Missense_Mutation_p.P90L|SNRPN_uc001yww.1_Missense_Mutation_p.P87L|SNRPN_uc001ywx.1_Missense_Mutation_p.P87L|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	87					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		GGGCCACCCCCCAAAGATGTA	0.488									Prader-Willi_syndrome				12	51					0	0	0	0	T	25221556	T	T	25221556	3	4	270	1	0	0	0	0	1	0	0	0	14934	623	22	4	270	4	SNRPN	15	25221556	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08		25221556	77309836	174	49062											
WDR72	256764	broad.mit.edu	37	chr15	54003099	54003099	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagtaaatgaggataaatGgtctctttaagcactcttcc	13	12	7	9	0	2	1	0	1	2	0	4	2	3	2	1	2	1	2	1	2	5	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr15:54003099G>T	uc002acj.2	-	9	951	c.909C>A	c.(907-909)ACC>ACA	p.T303T	WDR72_uc010bfi.1_Silent_p.T303T	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	303										lung(1)|skin(1)	2				all cancers(107;0.0511)		GAGGATAAATGGTCTCTTTAA	0.383													9	49					3.07112e-06	3.34246e-06	1	0	T	54003099	T	T	54003099	2	4	270	1	0	0	0	0	0	0	0	1	17390	1335	47	4		4	WDR72	15	54003099	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	28781543	54003099	48528293	175	49063											
CILP	8483	broad.mit.edu	37	chr15	65490300	65490300	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccaggttaatcacggagAtcacaaccccctggatctgc	10	8	9	14	1	3	1	2	0	1	1	4	3	4	2	3	3	2	2	3	3	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr15:65490300A>G	uc002aon.2	-	9	2505	c.2324T>C	c.(2323-2325)ATC>ACC	p.I775T		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	775					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						AATCACGGAGATCACAACCCC	0.562													54	87					0	0	0	0	G	65490300	G	G	65490300	3	3	270	1	0	0	0	0	1	0	0	0	3444	333	12	5	1234	5	CILP	15	65490300	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	11487201	65490300	37041092	176	49064											
DENND4A	10260	broad.mit.edu	37	chr15	65959832	65959832	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaagaaagaatcaatccaggTaagttactgggcaagtcaag	17	7	11	6	0	2	2	2	0	0	2	3	3	3	2	1	2	1	3	1	2	8	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr15:65959832T>C	uc002aph.2	-	28	5442	c.5064A>G	c.(5062-5064)TTA>TTG	p.L1688L	DENND4A_uc002api.2_Silent_p.L1731L	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1688					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TCAATCCAGGTAAGTTACTGG	0.368													9	47					0	0	0	0	C	65959832	C	C	65959832	2	2	270	1	0	0	0	0	0	0	0	1	4455	1635	57	5		5	DENND4A	15	65959832	Silent	SNP	T	TCGA-CV-7440-01A-11D-2129-08	469532	65959832	36571560	177	49065											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84581990	84581990	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaaggccccaagctgcccaCcgaacggccctgcctcctgg	7	5	11	18	2	0	1	0	1	0	0	1	2	1	1	7	3	4	1	7	3	3	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr15:84581990C>A	uc002bjz.3	+	16	2071	c.1847C>A	c.(1846-1848)ACC>AAC	p.T616N	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.T616N|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.T616N	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	616	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AAGCTGCCCACCGAACGGCCC	0.617													10	38					7.48243e-07	8.3104e-07	1	0	A	84581990	A	A	84581990	3	1	270	1	0	0	0	0	1	0	0	0	276	507	18	4	1905	4	ADAMTSL3	15	84581990	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	18622158	84581990	17949402	178	49066											
ACAN	176	broad.mit.edu	37	chr15	89398229	89398229	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agccatccccctcagaggaaCcattcccctcagtgaggcca	10	6	8	17	0	2	2	2	1	0	1	4	3	4	3	7	2	2	0	7	2	1	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr15:89398229C>A	uc010upo.1	+	12	2787	c.2413C>A	c.(2413-2415)CCA>ACA	p.P805T	ACAN_uc010upp.1_Missense_Mutation_p.P805T|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	805					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTCAGAGGAACCATTCCCCTC	0.602													7	8					0.000157383	0.000165313	1	0	A	89398229	A	A	89398229	3	1	270	1	0	0	0	0	1	0	0	0	117	507	18	4	2455	4	ACAN	15	89398229	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	4816239	89398229	13133163	179	49067											
CRTC3	64784	broad.mit.edu	37	chr15	91083350	91083350	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaatgtgagccagctgcggaGcagtgcgtcagagtttcagg	10	8	15	8	2	2	2	2	1	0	1	2	3	2	3	1	2	5	3	1	2	1	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr15:91083350G>A	uc002bpp.2	+	2	318	c.212G>A	c.(211-213)AGC>AAC	p.S71N	CRTC3_uc002bpn.2_Missense_Mutation_p.S71N|CRTC3_uc002bpo.2_Missense_Mutation_p.S71N	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	71	Required for interaction with HTLV-1 TAX.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CAGCTGCGGAGCAGTGCGTCA	0.413			T	MAML2	salivary gland mucoepidermoid								29	40					0	0	0	0	A	91083350	A	A	91083350	3	1	270	1	0	0	0	0	1	0	0	0	3916	971	34	4	218	4	CRTC3	15	91083350	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	1685121	91083350	11448042	180	49068											
WDR90	197335	broad.mit.edu	37	chr16	701826	701826	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcacttgtcccccagcaGtccggccgggccgccttggc	3	7	14	17	3	0	0	0	0	0	0	2	0	2	0	6	4	1	2	6	4	0	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr16:701826G>T	uc002cii.1	+	9	895	c.841_splice	c.e9-1	p.S281_splice	WDR90_uc002cig.1_Splice_Site_p.S281_splice|WDR90_uc002cih.1_Missense_Mutation_p.Q281H|WDR90_uc002cij.1_Splice_Site	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90											ovary(1)	1		Hepatocellular(780;0.0218)				TCCCCCAGCAGTCCGGCCGGG	0.687													20	49					7.41877e-09	8.74125e-09	1	0	T	701826	T	T	701826	5	4	270	1	0	0	0	0	0	0	1	0	17405	1043	36	4	874	4	WDR90	16	701826	Splice_Site	SNP	G	TCGA-CV-7440-01A-11D-2129-08		701826	89652927	181	49069											
C16orf42	115939	broad.mit.edu	37	chr16	1400139	1400139	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacctcctccgggctgccgCaggccgcgtacttgtccagg	4	7	13	17	4	0	0	0	0	0	0	3	0	3	0	6	3	2	4	6	3	1	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr16:1400139C>A	uc002cll.2	-	4	691	c.623G>T	c.(622-624)TGC>TTC	p.C208F	GNPTG_uc002clm.2_5'Flank	NM_001001410	NP_001001410	Q9UJK0	TSR3_HUMAN	hypothetical protein LOC115939	208					rRNA processing						0		Hepatocellular(780;0.0893)				CGGGCTGCCGCAGGCCGCGTA	0.622													17	18					1.5739e-10	1.93875e-10	1	0	A	1400139	A	A	1400139	3	1	270	1	0	0	0	0	1	0	0	0	1819	710	25	4	327	4	C16orf42	16	1400139	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	698313	1400139	88954614	182	49070											
NLRC3	197358	broad.mit.edu	37	chr16	3602217	3602217	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgagctctttcagactcctgTtctgcttcaagggcatctgc	6	14	9	12	0	5	2	2	1	3	1	6	2	6	2	1	1	3	4	1	1	1	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr16:3602217T>C	uc010btn.2	-	11	2741	c.2330A>G	c.(2329-2331)AAC>AGC	p.N777S	NLRC3_uc010bto.1_Missense_Mutation_p.N42S	NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	777	LRR 7.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CAGACTCCTGTTCTGCTTCAA	0.388													35	46					0	0	0	0	C	3602217	C	C	3602217	3	2	270	1	0	0	0	0	1	0	0	0	10522	1722	60	5	911	5	NLRC3	16	3602217	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	2202078	3602217	86752536	183	49071											
SBK1	388228	broad.mit.edu	37	chr16	28331653	28331653	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccgcgccgacgggctggCggtggacacgggcgtggacg	4	3	22	12	8	0	0	0	0	0	0	0	3	0	2	2	7	0	1	2	7	0	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr16:28331653C>T	uc002dpd.2	+	4	1475	c.686C>T	c.(685-687)GCG>GTG	p.A229V		NM_001024401	NP_001019572	Q52WX2	SBK1_HUMAN	SH3-binding kinase 1	229	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|kidney(1)	2						GACGGGCTGGCGGTGGACACG	0.736													8	19					0	0	0	0	T	28331653	T	T	28331653	3	4	270	1	0	0	0	0	1	0	0	0	13925	768	27	1	696	1	SBK1	16	28331653	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	24729436	28331653	62023100	184	49072											
SLC9A5	6553	broad.mit.edu	37	chr16	67289038	67289043	+	In_Frame_Del	DEL	TCTTTA	-	-																															ggtgcacgtcaatgagactcTctttatcatcgtctttggcg																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr16:67289038_67289043delTCTTTA	uc002esm.2	+	3	668_673	c.605_610delTCTTTA	c.(604-612)CTCTTTATC>CTC	p.FI203del	SLC9A5_uc010cee.2_5'UTR|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	203_204	Helical; (Potential).				regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		AATGAGACTCTCTTTATCATCGTCTT	0.583													---	---	---								-	67289043	-	-	67289038	7	5	270	1	0	1	0	1	0	0	0	0	14781	1551	54	0	615	0	SLC9A5	16	67289038	In_Frame_Del	DEL	TCTTTA	TCGA-CV-7440-01A-11D-2129-08	38957385	67289038	23065715	185	49073											
MYH4	4622	broad.mit.edu	37	chr17	10362566	10362566	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagctagaaaagtcatatgaAccttctcgatgagctcgatg	14	10	9	8	2	2	3	1	2	1	1	4	5	2	3	1	0	3	2	1	0	6	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:10362566A>T	uc002gmn.2	-	15	1698	c.1587_splice	c.e15+1	p.K529_splice	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AGTCATATGAACCTTCTCGAT	0.473													15	51					0	0	0	0	T	10362566	T	T	10362566	5	4	270	1	0	0	0	0	0	0	1	0	10090	57	2	5	4334	5	MYH4	17	10362566	Splice_Site	SNP	A	TCGA-CV-7440-01A-11D-2129-08		10362566	70832644	186	49074											
MYOCD	93649	broad.mit.edu	37	chr17	12661501	12661501	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caatttcagaggtaacacagCctccatcctatgaagatgcc	13	9	7	12	0	1	3	1	1	0	2	3	3	3	3	4	1	3	1	4	1	4	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:12661501C>T	uc002gnn.2	+	11	2457	c.2158C>T	c.(2158-2160)CCT>TCT	p.P720S	MYOCD_uc002gno.2_Missense_Mutation_p.P768S|MYOCD_uc002gnp.1_Missense_Mutation_p.P672S|MYOCD_uc002gnq.2_Intron	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	720					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GGTAACACAGCCTCCATCCTA	0.393													11	49					0	0	0	0	T	12661501	T	T	12661501	3	4	270	1	0	0	0	0	1	0	0	0	10140	739	26	4	2348	4	MYOCD	17	12661501	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	2298935	12661501	68533709	187	49075											
AMAC1	146861	broad.mit.edu	37	chr17	33521053	33521053	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagttcccagaagggggtCgccacgcagtttaagtagca	11	7	14	9	2	0	1	0	0	0	1	2	2	1	2	2	3	1	5	2	3	3	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:33521053C>A	uc002hjd.2	-	1	360	c.274G>T	c.(274-276)GAC>TAC	p.D92Y		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	92	DUF6 1.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		AGAAGGGGGTCGCCACGCAGT	0.582													88	120					9.24773e-40	1.29852e-39	1	0	A	33521053	A	A	33521053	3	1	270	1	0	0	0	0	1	0	0	0	559	884	31	3	746	3	AMAC1	17	33521053	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	20859552	33521053	47674157	188	49076											
MYO19	80179	broad.mit.edu	37	chr17	34852240	34852241	+	Frame_Shift_Del	DEL	TT	-	-																															gagactttctgcagtgaaacTttatcgatccctagagggga																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:34852240_34852241delTT	uc010wcy.1	-	27	3759_3760	c.2767_2768delAA	c.(2767-2769)AAGfs	p.K923fs	MYO19_uc002hmw.2_Frame_Shift_Del_p.K723fs|MYO19_uc010cuu.2_RNA|ZNHIT3_uc010cut.1_Intron	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	923	Mitochondrial targeting.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCAGTGAAACTTTATCGATCCC	0.495													---	---	---								-	34852241	-	-	34852240	7	5	270	1	0	1	0	1	0	0	0	0	10120	1609	56	0	148	0	MYO19	17	34852240	Frame_Shift_Del	DEL	TT	TCGA-CV-7440-01A-11D-2129-08	1331187	34852240	46342970	189	49077											
KRT34	3885	broad.mit.edu	37	chr17	39538432	39538432	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtagccgtggcagctgggggGcacgcagggccgggaggagc	6	3	22	10	3	0	0	0	0	0	0	0	2	0	2	2	7	3	5	2	7	1	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:39538432G>T	uc002hwm.2	-	1	205	c.193C>A	c.(193-195)CCC>ACC	p.P65T		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	65	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				CAGCTGGGGGGCACGCAGGGC	0.622													19	72					1.01871e-10	1.2606e-10	1	0	T	39538432	T	T	39538432	3	4	270	1	0	0	0	0	1	0	0	0	8510	1203	42	4	1145	4	KRT34	17	39538432	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	4686192	39538432	41656778	190	49078											
DHX8	1659	broad.mit.edu	37	chr17	41570954	41570954	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaagaccagcctgagcatGaaggtaggtgagatggtcag	13	6	14	8	0	1	4	1	3	0	2	1	5	1	4	3	3	2	2	3	3	3	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:41570954G>A	uc002idu.1	+	7	1078	c.1005G>A	c.(1003-1005)ATG>ATA	p.M335I	DHX8_uc010wif.1_Missense_Mutation_p.M244I|DHX8_uc010wig.1_Missense_Mutation_p.M335I	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	335	S1 motif.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		GCCTGAGCATGAAGGTAGGTG	0.527													15	70					0	0	0	0	A	41570954	A	A	41570954	3	1	270	1	0	0	0	0	1	0	0	0	4537	1290	45	2	1031	2	DHX8	17	41570954	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	2032522	41570954	39624256	191	49079											
KIF2B	84643	broad.mit.edu	37	chr17	51900732	51900732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggaccagcgtaccgccaCgaaatgggttgcgatgatcc	10	6	13	12	4	0	1	0	1	0	0	1	4	1	2	4	2	3	2	4	2	2	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:51900732C>T	uc002iua.2	+	1	494	c.338C>T	c.(337-339)ACG>ATG	p.T113M	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	113					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CGTACCGCCACGAAATGGGTT	0.592													19	92					0	0	0	0	T	51900732	T	T	51900732	3	4	270	1	0	0	0	0	1	0	0	0	8337	536	19	1	340	1	KIF2B	17	51900732	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	10329778	51900732	29294478	192	49080											
STXBP4	252983	broad.mit.edu	37	chr17	53158524	53158524	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaacttgttaaatctgttcGtgccttacttgatatggatt	9	17	9	6	1	1	1	0	1	1	0	2	3	1	3	1	2	3	2	1	2	5	7	rs35447433	byFrequency	TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:53158524G>A	uc002iuf.1	+	16	1676	c.1469G>A	c.(1468-1470)CGT>CAT	p.R490H	STXBP4_uc010dcd.1_Missense_Mutation_p.R468H	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	490						cytoplasm	calcium ion binding			ovary(1)	1						AAATCTGTTCGTGCCTTACTT	0.378													7	14					0	0	0	0	A	53158524	A	A	53158524	3	1	270	1	0	0	0	0	1	0	0	0	15421	1145	40	1	1523	1	STXBP4	17	53158524	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	1257792	53158524	28036686	193	49081											
BRIP1	83990	broad.mit.edu	37	chr17	59763502	59763502	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggttgaatggtgctgaatcTgctgccgtacccatttagaa	10	12	11	8	1	1	3	0	2	1	1	1	3	1	3	2	2	4	4	2	2	5	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:59763502T>A	uc002izk.1	-	19	2741	c.2600A>T	c.(2599-2601)CAG>CTG	p.Q867L	BRIP1_uc002izl.1_Missense_Mutation_p.Q248L	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	867					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						GTGCTGAATCTGCTGCCGTAC	0.358			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				9	83					0	0	0	0	A	59763502	A	A	59763502	3	1	270	1	0	0	0	0	1	0	0	0	1519	1580	55	5	1157	5	BRIP1	17	59763502	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	6604978	59763502	21431708	194	49082			1	75		2	2	13	N	T_C	9.4967e-05
BRIP1	83990	broad.mit.edu	37	chr17	59763514	59763514	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgaatctgctgccgtaccCatttagaaagtcctaaagaa	13	10	8	10	1	1	3	0	1	1	2	2	3	2	3	3	0	3	3	3	0	7	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:59763514C>A	uc002izk.1	-	19	2729	c.2588G>T	c.(2587-2589)TGG>TTG	p.W863L	BRIP1_uc002izl.1_Missense_Mutation_p.W244L	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	863					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						CTGCCGTACCCATTTAGAAAG	0.348			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				6	80					3.86212e-05	4.08842e-05	1	0	A	59763514	A	A	59763514	3	1	270	1	0	0	0	0	1	0	0	0	1519	595	21	4	1169	4	BRIP1	17	59763514	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	12	59763514	21431696	195	49083			1	75		2	2	13	N	T_C	9.4967e-05
CCDC46	201134	broad.mit.edu	37	chr17	64062993	64062993	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcattattctttctttctaaAatctgcaaataaatttaaaa	16	18	1	6	0	5	0	1	0	4	0	5	0	5	0	0	0	1	1	0	0	8	8			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:64062993A>G	uc002jfl.2	-	10	1077	c.858T>C	c.(856-858)ATT>ATC	p.I286I	CCDC46_uc010deo.2_Silent_p.I28I|CCDC46_uc002jfm.2_Silent_p.I286I|CCDC46_uc010dep.2_Silent_p.I244I	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	286	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			TTCTTTCTAAAATCTGCAAAT	0.244													7	13					0	0	0	0	G	64062993	G	G	64062993	2	3	270	1	0	0	0	0	0	0	0	1	2830	10	1	5		5	CCDC46	17	64062993	Silent	SNP	A	TCGA-CV-7440-01A-11D-2129-08	4299479	64062993	17132217	196	49084											
CACNG5	27091	broad.mit.edu	37	chr17	64881204	64881204	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcggctgagcaactgctcCgattactcaggccagttcct	7	10	9	15	2	1	1	1	1	0	0	4	2	3	1	4	2	4	4	4	2	2	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:64881204C>T	uc010wqi.1	+	6	912	c.675C>T	c.(673-675)TCC>TCT	p.S225S	CACNG5_uc010wqj.1_Silent_p.S225S	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	225				SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQF LHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSS SPC -> VKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPF WTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHF PPHSSCVLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			GCAACTGCTCCGATTACTCAG	0.622													13	35					0	0	0	0	T	64881204	T	T	64881204	2	4	270	1	0	0	0	0	0	0	0	1	2572	639	23	1		1	CACNG5	17	64881204	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	818211	64881204	16314006	197	49085											
ACTG1	71	broad.mit.edu	37	chr17	79478246	79478246	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggaacagcgcctccggaCaccggaaccgctcattgcca	9	5	11	16	4	1	0	1	0	0	0	2	3	2	3	5	3	4	2	5	3	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:79478246C>T	uc002kaj.1	-	3	795	c.770G>A	c.(769-771)TGT>TAT	p.C257Y	ACTG1_uc002kah.1_Missense_Mutation_p.C135Y|ACTG1_uc002kai.1_Missense_Mutation_p.C214Y|ACTG1_uc002kak.1_Missense_Mutation_p.C257Y|ACTG1_uc010wun.1_Missense_Mutation_p.C257Y|ACTG1_uc002kal.1_Missense_Mutation_p.C257Y|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	257					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			CGCCTCCGGACACCGGAACCG	0.577													18	108					0	0	0	0	T	79478246	T	T	79478246	3	4	270	1	0	0	0	0	1	0	0	0	196	478	17	4	369	4	ACTG1	17	79478246	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	14597042	79478246	1716964	198	49086											
FSCN2	25794	broad.mit.edu	37	chr17	79503253	79503255	+	In_Frame_Del	DEL	GAA	-	-																															aacgggcgctacgtgtgcatGaagaagaatgggcagctggc																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:79503253_79503255delGAA	uc010wup.1	+	3	1206_1208	c.1065_1067delGAA	c.(1063-1068)ATGAAG>ATG	p.K357del	FSCN2_uc010wuo.1_In_Frame_Del_p.K357del	NM_012418	NP_036550	O14926	FSCN2_HUMAN	fascin 2 isoform 1	357					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging				0	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			ACGTGTGCATGAAGAAGAATGGG	0.601													---	---	---								-	79503255	-	-	79503253	7	5	270	1	0	1	0	1	0	0	0	0	6102	1290	45	0	914	0	FSCN2	17	79503253	In_Frame_Del	DEL	GAA	TCGA-CV-7440-01A-11D-2129-08	25007	79503253	1691957	199	49087											
PCYT2	5833	broad.mit.edu	37	chr17	79865452	79865452	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccaaaactgtctgcatacTcccggtactcagaggacatc	11	9	8	13	1	2	1	1	0	1	1	4	2	3	2	2	2	5	2	2	2	4	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr17:79865452T>C	uc002kcf.1	-	6	578	c.515A>G	c.(514-516)GAG>GGG	p.E172G	PCYT2_uc010wva.1_Missense_Mutation_p.E140G|PCYT2_uc010wvb.1_Missense_Mutation_p.E140G|PCYT2_uc002kce.1_Missense_Mutation_p.E94G|PCYT2_uc002kcg.1_Missense_Mutation_p.E183G|PCYT2_uc002kch.1_Missense_Mutation_p.E172G|PCYT2_uc002kci.1_Missense_Mutation_p.E113G|PCYT2_uc010dii.1_Missense_Mutation_p.E172G|PCYT2_uc010wvc.1_Missense_Mutation_p.E94G	NM_002861	NP_002852	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	172	Catalytic 1 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GTCTGCATACTCCCGGTACTC	0.667													3	9					0	0	0	0	C	79865452	C	C	79865452	3	2	270	1	0	0	0	0	1	0	0	0	11666	1551	54	5	744	5	PCYT2	17	79865452	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	362199	79865452	1329758	200	49088											
B3GNTL1	146712	broad.mit.edu	37	chr17	80914579	80914579	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccacactcaccagcttcaCgcagatgacgaagggtggcc	10	5	10	16	2	2	2	2	1	0	1	2	3	2	2	4	2	1	2	4	2	1	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	e55ecf9c-0059-48ac-ba84-6879a8ec7311	g.chr17:80914579C>A	uc002kgg.1	-	11	1011	c.997G>T	c.(997-999)GTG>TTG	p.V333L	B3GNTL1_uc002kgf.1_Missense_Mutation_p.V222L|B3GNTL1_uc002kge.1_RNA	NM_001009905	NP_001009905	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal	333							transferase activity, transferring glycosyl groups			ovary(1)|pancreas(1)	2	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			ACCAGCTTCACGCAGATGACG	0.652													3	3					0.00909568	0.00926046	1	0	A	80914579	A	A	80914579	3	1	270	1	0	0	0	0	1	0	0	0	1267	536	19	3	96	3	B3GNTL1	17	80914579	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	1049127	80914579	280631	201	49089											
SMCHD1	23347	broad.mit.edu	37	chr18	2703849	2703852	+	Frame_Shift_Del	DEL	GAAT	-	-																															gggcaacatatgcagcaataGaatgggatggaaagatatac																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr18:2703849_2703852delGAAT	uc002klm.3	+	13	1996_1999	c.1807_1810delGAAT	c.(1807-1812)GAATGGfs	p.E603fs	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_5'Flank	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	603_604					chromosome organization		ATP binding				0						TGCAGCAATAGAATGGGATGGAAA	0.284													---	---	---								-	2703852	-	-	2703849	7	5	270	1	0	1	0	1	0	0	0	0	14852	943	33	0	1857	0	SMCHD1	18	2703849	Frame_Shift_Del	DEL	GAAT	TCGA-CV-7440-01A-11D-2129-08		2703849	75373399	202	49090											
MYOM1	8736	broad.mit.edu	37	chr18	3116435	3116435	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaccagtgaccggagtccgcCcggagtggactggcggcttc	7	6	15	13	4	0	1	0	1	0	0	2	4	1	4	4	5	1	1	4	5	1	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr18:3116435C>T	uc002klp.2	-	21	3531	c.3197G>A	c.(3196-3198)GGG>GAG	p.G1066E	MYOM1_uc002klq.2_Missense_Mutation_p.G970E	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1066	Fibronectin type-III 5.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CGGAGTCCGCCCGGAGTGGAC	0.547													22	23					0	0	0	0	T	3116435	T	T	3116435	3	4	270	1	0	0	0	0	1	0	0	0	10144	623	22	4	1932	4	MYOM1	18	3116435	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	412586	3116435	74960813	203	49091											
L3MBTL4	91133	broad.mit.edu	37	chr18	5956275	5956275	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagggagttcctgggaatGcctgaacatcaggatagagt	11	10	13	7	0	2	2	2	1	0	1	3	5	3	5	2	3	2	1	2	3	3	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr18:5956275G>A	uc002kmz.3	-	20	1976	c.1816C>T	c.(1816-1818)CAT>TAT	p.H606Y	L3MBTL4_uc010dkt.2_Missense_Mutation_p.H606Y|L3MBTL4_uc002kmy.3_Missense_Mutation_p.H435Y	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	606	SAM.				chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				TCCTGGGAATGCCTGAACATC	0.498													48	184					0	0	0	0	A	5956275	A	A	5956275	3	1	270	1	0	0	0	0	1	0	0	0	8634	1319	46	4	59	4	L3MBTL4	18	5956275	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	2839840	5956275	72120973	204	49092											
FAM59A	64762	broad.mit.edu	37	chr18	29867752	29867752	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgttcacaaacttatagcGgtgcccctcacggatgaagt	11	10	10	10	2	2	1	2	1	0	0	2	3	2	2	2	2	3	1	2	2	4	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr18:29867752G>A	uc002kxl.2	-	4	864	c.808C>T	c.(808-810)CGC>TGC	p.R270C	FAM59A_uc002kxk.1_Missense_Mutation_p.R270C	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	270	CABIT.									ovary(1)|skin(1)	2						AACTTATAGCGGTGCCCCTCA	0.527													16	67					0	0	0	0	A	29867752	A	A	29867752	3	1	270	1	0	0	0	0	1	0	0	0	5624	1116	39	1	1831	1	FAM59A	18	29867752	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	23911477	29867752	48209496	205	49093											
ASXL3	80816	broad.mit.edu	37	chr18	31323155	31323155	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaagctctttgcaaagcatCaagctcgagcccatctcttc	10	11	6	14	1	3	0	1	0	2	0	6	1	3	0	1	0	5	4	1	0	3	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr18:31323155C>G	uc010dmg.1	+	12	3398	c.3343C>G	c.(3343-3345)CAA>GAA	p.Q1115E	ASXL3_uc002kxq.2_Missense_Mutation_p.Q822E	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TGCAAAGCATCAAGCTCGAGC	0.527													4	23					0	0	0	0	G	31323155	G	G	31323155	3	3	270	1	0	0	0	0	1	0	0	0	1070	827	29	2	3389	2	ASXL3	18	31323155	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	1455403	31323155	46754093	206	49094											
TCEB3B	51224	broad.mit.edu	37	chr18	44559422	44559422	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcgaattgccttggccatCagcggggccactttcttggc	5	12	11	13	2	3	0	1	0	2	0	4	1	3	0	3	4	2	0	3	4	1	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr18:44559422C>T	uc002lcr.1	-	1	2567	c.2214G>A	c.(2212-2214)CTG>CTA	p.L738L	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron|TCEB3C_uc010xdb.1_5'Flank	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	738					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CCTTGGCCATCAGCGGGGCCA	0.562													21	127					0	0	0	0	T	44559422	T	T	44559422	2	4	270	1	0	0	0	0	0	0	0	1	15748	813	29	2		2	TCEB3B	18	44559422	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	13236267	44559422	33517826	207	49095											
CDH19	28513	broad.mit.edu	37	chr18	64202289	64202289	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgatccagtgagttacttgTagtgattgtaccattatcat	11	15	8	7	1	1	2	1	2	0	0	2	3	2	2	2	0	2	3	2	0	4	6			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr18:64202289T>C	uc002lkc.1	-	8	1408	c.1270A>G	c.(1270-1272)ACA>GCA	p.T424A	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.T424A|CDH19_uc002lkd.2_Missense_Mutation_p.T424A	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	424	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				GAGTTACTTGTAGTGATTGTA	0.328													4	33					0	0	0	0	C	64202289	C	C	64202289	3	2	270	1	0	0	0	0	1	0	0	0	3119	1638	57	5	1068	5	CDH19	18	64202289	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	19642867	64202289	13874959	208	49096											
TMPRSS9	360200	broad.mit.edu	37	chr19	2408379	2408379	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagacccgacgaagtgggtgGcctacgtgggtgcgacctac	9	6	15	11	4	0	1	0	0	0	1	0	4	0	1	3	3	3	0	3	3	4	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:2408379G>A	uc010xgx.1	+	7	766	c.766G>A	c.(766-768)GCC>ACC	p.A256T	TMPRSS9_uc002lvv.1_Missense_Mutation_p.A290T	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	256	Extracellular (Potential).|Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGTGGGTGGCCTACGTGGG	0.542													17	21					0	0	0	0	A	2408379	A	A	2408379	3	1	270	1	0	0	0	0	1	0	0	0	16319	1203	42	4	792	4	TMPRSS9	19	2408379	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08		2408379	56720604	209	49097											
HDGFRP2	84717	broad.mit.edu	37	chr19	4499579	4499579	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcctcggcccaaagatcgAggcggtgcagaaagtgaaca	12	5	14	10	3	0	3	0	1	0	2	3	4	1	3	2	4	2	1	2	4	3	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:4499579A>G	uc002mao.2	+	14	1760	c.1667A>G	c.(1666-1668)GAG>GGG	p.E556G	HDGFRP2_uc002map.2_Missense_Mutation_p.E556G|HDGFRP2_uc010dtz.1_RNA|HDGFRP2_uc010dua.2_Missense_Mutation_p.E21G|HDGFRP2_uc002maq.1_Missense_Mutation_p.E21G	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	556	Potential.				transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						CCAAAGATCgaggcggtgcag	0.279													8	3					0	0	0	0	G	4499579	G	G	4499579	3	3	270	1	0	0	0	0	1	0	0	0	7059	304	11	5	1721	5	HDGFRP2	19	4499579	Missense_Mutation	SNP	A	TCGA-CV-7440-01A-11D-2129-08	2091200	4499579	54629404	210	49098											
NOTCH3	4854	broad.mit.edu	37	chr19	15271836	15271836	+	Frame_Shift_Del	DEL	G	-	-																															ggccgctcctgcggggagacGggggtccctgggttgagcag																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:15271836delG	uc002nan.2	-	33	6679	c.6603delC	c.(6601-6603)CCCfs	p.P2201fs		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	2201	Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GCGGGGAGACGGGGGTCCCTG	0.741													---	---	---								-	15271836	-	-	15271836	7	5	270	1	0	1	0	1	0	0	0	0	10604	1103	39	0	366	0	NOTCH3	19	15271836	Frame_Shift_Del	DEL	G	TCGA-CV-7440-01A-11D-2129-08	10772257	15271836	43857147	211	49099											
CYP4F3	4051	broad.mit.edu	37	chr19	15760804	15760804	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcagatcctcctgtacatAgacttcctgtattatctcac	10	13	5	13	0	1	2	1	0	1	2	5	2	4	2	3	0	2	3	3	0	4	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:15760804A>T	uc002nbj.2	+	7	779	c.729A>T	c.(727-729)ATA>ATT	p.I243I	CYP4F3_uc010xok.1_Silent_p.I243I|CYP4F3_uc010xol.1_Silent_p.I243I|CYP4F3_uc010xom.1_Silent_p.I94I|CYP4F3_uc002nbk.2_Silent_p.I243I|CYP4F3_uc010xon.1_5'UTR	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	243					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TCCTGTACATAGACTTCCTGT	0.562													7	71					0	0	0	0	T	15760804	T	T	15760804	2	4	270	1	0	0	0	0	0	0	0	1	4207	410	15	5		5	CYP4F3	19	15760804	Silent	SNP	A	TCGA-CV-7440-01A-11D-2129-08	488968	15760804	43368179	212	49100											
ZNF506	440515	broad.mit.edu	37	chr19	19905448	19905448	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctgtctaatatgaattttCttatgtttattaagggctga	10	20	7	4	0	3	2	0	2	3	0	3	2	3	2	0	1	0	2	0	1	6	9			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:19905448C>G	uc010eci.2	-	4	1396	c.1248G>C	c.(1246-1248)AAG>AAC	p.K416N	ZNF506_uc002nog.2_Intron|ZNF506_uc002noh.3_Missense_Mutation_p.K384N	NM_001099269	NP_001092739	Q5JVG8	ZN506_HUMAN	zinc finger protein 506 isoform 1	416	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding				0						TATGAATTTTCTTATGTTTAT	0.338													28	29					0	0	0	0	G	19905448	G	G	19905448	3	3	270	1	0	0	0	0	1	0	0	0	18019	912	32	2	90	2	ZNF506	19	19905448	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	4144644	19905448	39223535	213	49101											
NPHS1	4868	broad.mit.edu	37	chr19	36340485	36340485	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtgaatgaggccttgatggGggcctccagtgctgggctag	6	9	18	8	0	0	3	0	3	0	0	1	3	1	3	3	5	1	2	3	5	2	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:36340485G>T	uc002oby.2	-	6	679	c.679C>A	c.(679-681)CCC>ACC	p.P227T		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	227	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCCTTGATGGGGGCCTCCAGT	0.587													28	55					1.30988e-24	1.81111e-24	1	0	T	36340485	T	T	36340485	3	4	270	1	0	0	0	0	1	0	0	0	10636	1232	43	4	3142	4	NPHS1	19	36340485	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	16435037	36340485	22788498	214	49102											
HIF3A	64344	broad.mit.edu	37	chr19	46815462	46815462	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcccgatgacctgatcggctGttccgcctacgagtacatcc	7	10	9	15	4	0	2	0	2	0	0	4	4	3	2	5	1	2	3	5	1	2	3			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:46815462G>C	uc002peh.2	+	7	844	c.815G>C	c.(814-816)TGT>TCT	p.C272S	HIF3A_uc002pef.1_Missense_Mutation_p.C272S|HIF3A_uc002peg.3_Missense_Mutation_p.C272S|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Missense_Mutation_p.C216S|HIF3A_uc002pej.1_Missense_Mutation_p.C203S|HIF3A_uc002pek.2_Missense_Mutation_p.C216S|HIF3A_uc010xxy.1_Missense_Mutation_p.C203S|HIF3A_uc002pel.2_Missense_Mutation_p.C270S|HIF3A_uc010xxz.1_Missense_Mutation_p.C221S	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	272	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CTGATCGGCTGTTCCGCCTAC	0.602													57	98					0	0	0	0	C	46815462	C	C	46815462	3	2	270	1	0	0	0	0	1	0	0	0	7144	1377	48	4	865	4	HIF3A	19	46815462	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	10474977	46815462	12313521	215	49103											
MYH14	79784	broad.mit.edu	37	chr19	50766677	50766677	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtggcggctgtttaccaaGgtgagggcagcctggggagg	6	8	20	7	1	0	1	0	1	0	0	0	2	0	2	2	8	2	3	2	8	2	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-11A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	e55ecf9c-0059-48ac-ba84-6879a8ec7311	g.chr19:50766677G>A	uc002prr.1	+	20	2618	c.2571G>A	c.(2569-2571)AAG>AAA	p.K857K	MYH14_uc010enu.1_Silent_p.K898K|MYH14_uc002prq.1_Silent_p.K865K	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	857					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		TGTTTACCAAGGTGAGGGCAG	0.532													3	13					0	0	0	0	A	50766677	A	A	50766677	2	1	270	1	0	0	0	0	0	0	0	1	10086	1014	35	4		4	MYH14	19	50766677	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	3951215	50766677	8362306	216	49104											
ZNF432	9668	broad.mit.edu	37	chr19	52537631	52537631	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacagtaaaaccttttccaCattcactacatagatatgac	15	12	3	11	0	2	2	2	1	0	1	3	2	3	2	2	0	2	1	2	0	5	7			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:52537631C>A	uc002pyk.2	-	5	1619	c.1301G>T	c.(1300-1302)TGT>TTT	p.C434F		NM_014650	NP_055465	O94892	ZN432_HUMAN	zinc finger protein 432	434	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|pancreas(1)	3		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		ACCTTTTCCACATTCACTACA	0.408													16	71					6.31663e-08	7.25341e-08	1	0	A	52537631	A	A	52537631	3	1	270	1	0	0	0	0	1	0	0	0	17973	478	17	4	661	4	ZNF432	19	52537631	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	1770954	52537631	6591352	217	49105											
ZNF610	162963	broad.mit.edu	37	chr19	52870011	52870011	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattcactgcgtaccttacaGatggaatgaatgtggcaaaa	15	10	9	7	1	1	2	1	1	0	1	1	3	1	3	1	2	3	2	1	2	7	3	rs144093967	byFrequency	TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:52870011G>C	uc002pyx.3	+	6	1786	c.1380G>C	c.(1378-1380)CAG>CAC	p.Q460H	ZNF610_uc002pyy.3_Missense_Mutation_p.Q460H|ZNF610_uc002pyz.3_Missense_Mutation_p.Q417H|ZNF610_uc002pza.2_Missense_Mutation_p.Q460H	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GTACCTTACAGATGGAATGAA	0.393													3	50					0	0	0	0	C	52870011	C	C	52870011	3	2	270	1	0	0	0	0	1	0	0	0	18103	933	33	2	1394	2	ZNF610	19	52870011	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	332380	52870011	6258972	218	49106											
ZNF415	55786	broad.mit.edu	37	chr19	53612056	53612056	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaaccttaccacattcattGcatttgtaaggtttctctcc	11	15	4	11	0	2	0	1	0	1	0	4	0	3	0	3	1	3	3	3	1	4	6			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:53612056G>A	uc002qax.2	-	7	1735	c.1386C>T	c.(1384-1386)TGC>TGT	p.C462C	ZNF415_uc002qat.2_Silent_p.C426C|ZNF415_uc002qaw.2_Silent_p.C414C|ZNF415_uc010yds.1_Silent_p.C414C|ZNF415_uc010ydt.1_Silent_p.C414C|ZNF415_uc002qau.2_Silent_p.C401C|ZNF415_uc002qav.2_Silent_p.C426C|ZNF415_uc002qba.2_Silent_p.C184C|ZNF415_uc002qay.2_Silent_p.C401C|ZNF415_uc002qaz.2_Silent_p.C462C	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	462	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		CACATTCATTGCATTTGTAAG	0.403													23	41					0	0	0	0	A	53612056	A	A	53612056	2	1	270	1	0	0	0	0	0	0	0	1	17959	1311	46	4		4	ZNF415	19	53612056	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	742045	53612056	5516927	219	49107											
NLRP12	91662	broad.mit.edu	37	chr19	54313980	54313980	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgtttctcctcccagcagagGcaccagggtccctgaggatc	7	8	11	15	1	1	2	0	1	1	1	5	3	3	3	4	3	1	3	4	3	0	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:54313980G>T	uc002qch.3	-	3	1153	c.933C>A	c.(931-933)TGC>TGA	p.C311*	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Nonsense_Mutation_p.C311*|NLRP12_uc002qcj.3_Nonsense_Mutation_p.C311*|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Nonsense_Mutation_p.C311*	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	311	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCCAGCAGAGGCACCAGGGTC	0.567													14	46					2.32078e-09	2.77063e-09	1	0	T	54313980	T	T	54313980	4	4	270	1	0	0	0	0	0	1	0	0	10528	1195	42	4	2380	4	NLRP12	19	54313980	Nonsense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	701924	54313980	4815003	220	49108											
TSEN34	79042	broad.mit.edu	37	chr19	54695621	54695621	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagagcttccaggagcagaGcgccttggcagctgaggccc	8	5	16	12	1	0	3	0	1	0	2	1	5	1	4	3	4	4	4	3	4	0	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:54695621G>A	uc002qdu.2	+	3	402	c.293G>A	c.(292-294)AGC>AAC	p.S98N	MBOAT7_uc002qdq.2_5'Flank|MBOAT7_uc002qdr.2_5'Flank|MBOAT7_uc002qds.2_5'Flank|MBOAT7_uc010yen.1_5'Flank|MBOAT7_uc002qdt.3_5'Flank|TSEN34_uc010yeo.1_Missense_Mutation_p.S98N|TSEN34_uc002qdv.2_Missense_Mutation_p.S98N|TSEN34_uc002qdw.2_Missense_Mutation_p.S98N	NM_024075	NP_076980	Q9BSV6	SEN34_HUMAN	tRNA-intron endonuclease 34	98					mRNA processing|tRNA-type intron splice site recognition and cleavage	nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity				0	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CAGGAGCAGAGCGCCTTGGCA	0.582													25	72					0	0	0	0	A	54695621	A	A	54695621	3	1	270	1	0	0	0	0	1	0	0	0	16680	971	34	4	299	4	TSEN34	19	54695621	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	381641	54695621	4433362	221	49109											
LILRB5	10990	broad.mit.edu	37	chr19	54761048	54761048	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaatcaggactgagagggtGagggtcatggcgtcagctcc	10	7	15	9	1	3	2	3	2	0	1	4	4	4	3	1	4	1	1	1	4	1	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:54761048G>A	uc002qex.2	-	1	120	c.9C>T	c.(7-9)CTC>CTT	p.L3L	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Silent_p.L3L|LILRB5_uc002qey.2_Silent_p.L3L|LILRB5_uc002qez.2_Silent_p.L3L|LILRB5_uc002qfa.1_5'UTR|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	3					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGAGAGGGTGAGGGTCATGG	0.587													9	44					0	0	0	0	A	54761048	A	A	54761048	2	1	270	1	0	0	0	0	0	0	0	1	8835	1277	45	2		2	LILRB5	19	54761048	Silent	SNP	G	TCGA-CV-7440-01A-11D-2129-08	65427	54761048	4367935	222	49110											
ZNF471	57573	broad.mit.edu	37	chr19	57035697	57035697	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttttaatatctttcagattgGgaatctatatatgtgacaca	13	17	6	5	0	3	2	1	1	2	1	3	3	3	3	0	1	0	0	0	1	6	8			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:57035697G>T	uc002qnh.2	+	5	394	c.261G>T	c.(259-261)TGG>TGT	p.W87C		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		TTTCAGATTGGGAATCTATAT	0.333													14	50					2.23348e-06	2.4505e-06	1	0	T	57035697	T	T	57035697	3	4	270	1	0	0	0	0	1	0	0	0	17997	1241	43	4	275	4	ZNF471	19	57035697	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	2274649	57035697	2093286	223	49111											
ZNF211	10520	broad.mit.edu	37	chr19	58152339	58152340	+	Frame_Shift_Del	DEL	CT	-	-																															gcagcacattacagaggcacCtttcagaagttatgtggaca																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:58152339_58152340delCT	uc002qpq.2	+	3	665_666	c.485_486delCT	c.(484-486)CCTfs	p.P162fs	ZNF211_uc010yhb.1_Frame_Shift_Del_p.P166fs|ZNF211_uc002qpp.2_Frame_Shift_Del_p.P175fs|ZNF211_uc002qpr.2_Frame_Shift_Del_p.P226fs|ZNF211_uc002qps.2_Frame_Shift_Del_p.P227fs|ZNF211_uc002qpt.2_Frame_Shift_Del_p.P174fs|ZNF211_uc010yhc.1_Frame_Shift_Del_p.P174fs|ZNF211_uc010yhd.1_Frame_Shift_Del_p.P101fs|ZNF211_uc010yhe.1_Frame_Shift_Del_p.P153fs	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	162						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACAGAGGCACCTTTCAGAAGTT	0.47													---	---	---								-	58152340	-	-	58152339	7	5	270	1	0	1	0	1	0	0	0	0	17834	681	24	0	538	0	ZNF211	19	58152339	Frame_Shift_Del	DEL	CT	TCGA-CV-7440-01A-11D-2129-08	1116642	58152339	976644	224	49112											
ZNF135	7694	broad.mit.edu	37	chr19	58579086	58579086	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggagaaaagccctatgagTgtggtgagtgtgggaaagcc	12	7	16	6	0	0	3	0	2	0	1	0	5	0	4	2	3	2	0	2	3	4	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr19:58579086T>A	uc010yhq.1	+	5	1366	c.1270T>A	c.(1270-1272)TGT>AGT	p.C424S	ZNF135_uc002qre.2_Missense_Mutation_p.C412S|ZNF135_uc002qrd.1_Intron|ZNF135_uc002qrf.2_Missense_Mutation_p.C370S|ZNF135_uc002qrg.2_Missense_Mutation_p.C382S|ZNF135_uc010yhr.1_Missense_Mutation_p.C233S	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	424					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		GCCCTATGAGTGTGGTGAGTG	0.542													18	25					0	0	0	0	A	58579086	A	A	58579086	3	1	270	1	0	0	0	0	1	0	0	0	17792	1696	59	5	1437	5	ZNF135	19	58579086	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	426747	58579086	549897	225	49113											
CSNK2A1	1457	broad.mit.edu	37	chr20	489118	489118	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cattccaccacatgtgactcGtaatcccagtattctcgagg	10	11	7	13	2	1	1	0	1	1	0	5	2	3	1	3	1	0	2	3	1	2	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr20:489118G>T	uc002wdw.1	-	3	471	c.78C>A	c.(76-78)TAC>TAA	p.Y26*	CSNK2A1_uc002wdx.1_Nonsense_Mutation_p.Y26*|CSNK2A1_uc002wdy.1_Intron	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	26					axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CATGTGACTCGTAATCCCAGT	0.458													33	29					1.59361e-14	2.05651e-14	1	0	T	489118	T	T	489118	4	4	270	1	0	0	0	0	0	1	0	0	3974	1140	40	3	1145	3	CSNK2A1	20	489118	Nonsense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08		489118	62536402	226	49114											
ZHX3	23051	broad.mit.edu	37	chr20	39832794	39832794	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgttcctatcaggggccCgttggcggcatgggggtttt	4	12	15	10	2	1	0	1	0	0	0	2	0	2	0	2	6	0	4	2	6	1	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr20:39832794C>A	uc002xjs.1	-	3	1141	c.763G>T	c.(763-765)GGG>TGG	p.G255W	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.G255W|ZHX3_uc002xjt.1_Missense_Mutation_p.G255W|ZHX3_uc002xju.1_Missense_Mutation_p.G255W|ZHX3_uc002xjv.1_Missense_Mutation_p.G255W|ZHX3_uc002xjw.1_Missense_Mutation_p.G255W|ZHX3_uc010ggg.1_Missense_Mutation_p.G255W	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	255	Required for homodimerization and interaction with NFYA.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				ATCAGGGGCCCGTTGGCGGCA	0.582													22	69					1.87028e-06	2.06035e-06	1	0	A	39832794	A	A	39832794	3	1	270	1	0	0	0	0	1	0	0	0	17744	652	23	3	2115	3	ZHX3	20	39832794	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	39343676	39832794	23192726	227	49115											
L3MBTL	26013	broad.mit.edu	37	chr20	42168941	42168941	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagtcgccaagtggaccaTcgatgaggtgaggagcgagg	11	5	17	8	3	0	2	0	2	0	0	2	7	0	4	2	4	1	0	2	4	1	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr20:42168941T>A	uc010zwh.1	+	20	2304	c.2258T>A	c.(2257-2259)ATC>AAC	p.I753N	L3MBTL_uc002xkl.2_Missense_Mutation_p.I685N|L3MBTL_uc002xkm.2_Missense_Mutation_p.I685N|L3MBTL_uc010ggl.2_Missense_Mutation_p.I690N|L3MBTL_uc002xkn.1_Missense_Mutation_p.I444N|L3MBTL_uc002xko.2_Missense_Mutation_p.I337N|L3MBTL_uc002xkp.2_Missense_Mutation_p.I73N|SGK2_uc002xkq.1_5'UTR	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	685	SAM.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			AAGTGGACCATCGATGAGGTG	0.612													34	43					0	0	0	0	A	42168941	A	A	42168941	3	1	270	1	0	0	0	0	1	0	0	0	8631	1435	50	5	2120	5	L3MBTL	20	42168941	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	2336147	42168941	20856579	228	49116											
EDN3	1908	broad.mit.edu	37	chr20	57896161	57896161	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagggaatctgcagctctCacatcggccacacttgcgct	8	9	9	15	2	2	0	1	0	2	0	5	1	3	1	2	2	3	3	2	2	1	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr20:57896161C>T	uc002yap.2	+	3	824	c.455C>T	c.(454-456)TCA>TTA	p.S152L	EDN3_uc002yao.1_Missense_Mutation_p.S152L|EDN3_uc002yaq.2_Missense_Mutation_p.S152L|EDN3_uc002yar.2_Missense_Mutation_p.S152L|EDN3_uc002yas.2_Missense_Mutation_p.S152L	NM_000114	NP_000105	P14138	EDN3_HUMAN	endothelin 3 isoform 1 preproprotein	152					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			skin(1)	1	all_lung(29;0.0115)					CTGCAGCTCTCACATCGGCCA	0.582													33	77					0	0	0	0	T	57896161	T	T	57896161	3	4	270	1	0	0	0	0	1	0	0	0	4940	838	29	2	465	2	EDN3	20	57896161	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	15727220	57896161	5129359	229	49117											
LAMA5	3911	broad.mit.edu	37	chr20	60908211	60908211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgctccgtggggcagggccGgggcaggctgttgtcctggc	2	8	19	12	2	0	0	0	0	0	0	2	0	2	0	3	7	1	5	3	7	0	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr20:60908211G>A	uc002ycq.2	-	26	3284	c.3217C>T	c.(3217-3219)CGG>TGG	p.R1073W		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1073	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGCAGGGCCGGGGCAGGCTG	0.701													8	6					0	0	0	0	A	60908211	A	A	60908211	3	1	270	1	0	0	0	0	1	0	0	0	8649	1115	39	1	8090	1	LAMA5	20	60908211	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	3012050	60908211	2117309	230	49118											
TFIP11	24144	broad.mit.edu	37	chr22	26894935	26894935	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgatctcggtgccataagTgcagtcctgaggagaaaggt	11	9	14	7	1	1	3	0	2	1	1	3	5	2	3	2	3	2	1	2	3	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr22:26894935T>A	uc003acr.2	-	9	1710	c.1336A>T	c.(1336-1338)ACT>TCT	p.T446S	TFIP11_uc003acs.2_Missense_Mutation_p.T446S|TFIP11_uc003act.2_Missense_Mutation_p.T446S	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	446					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						GTGCCATAAGTGCAGTCCTGA	0.557													106	63					0	0	0	0	A	26894935	A	A	26894935	3	1	270	1	0	0	0	0	1	0	0	0	15873	1696	59	5	1201	5	TFIP11	22	26894935	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08		26894935	24409631	231	49119											
CHEK2	11200	broad.mit.edu	37	chr22	29095857	29095867	+	Frame_Shift_Del	DEL	AGCTTGCAGGT	-	-																															agagcatctggtaaaaatagAgcttgcaggtagcttctttc																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr22:29095857_29095867delAGCTTGCAGGT	uc003adu.1	-	9	1039_1049	c.967_977delACCTGCAAGCT	c.(967-978)ACCTGCAAGCTCfs	p.T323fs	CHEK2_uc003ads.1_Frame_Shift_Del_p.T102fs|CHEK2_uc010gvh.1_Frame_Shift_Del_p.T232fs|CHEK2_uc010gvi.1_Frame_Shift_Del_p.T323fs|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Frame_Shift_Del_p.T366fs|CHEK2_uc003adv.1_Frame_Shift_Del_p.T323fs|CHEK2_uc003adw.1_Frame_Shift_Del_p.T323fs|CHEK2_uc003adx.1_Frame_Shift_Del_p.T102fs|CHEK2_uc003ady.1_Frame_Shift_Del_p.T323fs|CHEK2_uc003adz.1_Frame_Shift_Del_p.T127fs	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	323_326	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						GTAAAAATAGAGCTTGCAGGTAGCTTCTTTC	0.464			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				---	---	---								-	29095867	-	-	29095857	7	5	270	1	0	1	0	1	0	0	0	0	3350	304	11	0	682	0	CHEK2	22	29095857	Frame_Shift_Del	DEL	AGCTTGCAGGT	TCGA-CV-7440-01A-11D-2129-08	2200922	29095857	22208709	232	49120											
ADSL	158	broad.mit.edu	37	chr22	40757500	40757501	+	Missense_Mutation	DNP	GC	TG	TG																															ttacatgggcaggctcaagtGcgatgccatataagcggaat																										TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr22:40757500_40757501GC>TG	uc003ayp.3	+	9	930_931	c.871_872GC>TG	c.(871-873)GCG>TGG	p.A291W	ADSL_uc003ays.3_Missense_Mutation_p.A291W|ADSL_uc003ayq.3_Missense_Mutation_p.A291W|ADSL_uc003ayr.3_Missense_Mutation_p.A67W|ADSL_uc003ayt.3_Missense_Mutation_p.A276W|ADSL_uc010gyb.1_RNA	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	291					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1						AGGCTCAAGTGCGATGCCATAT	0.525													17	99					0	0	0	0	TG	40757501	TG	TG	40757500	3	4	270	1	0	0	0	0	1	0	0	0	346	1319	46	4	905	4	ADSL	22	40757500	Missense_Mutation	DNP	GC	TCGA-CV-7440-01A-11D-2129-08	11661643	40757500	10547066	233	49121											
SGSM3	27352	broad.mit.edu	37	chr22	40800432	40800432	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccgctccctggtgctggcCggcatcccacatggcatgag	5	8	12	16	2	0	1	0	1	0	0	3	1	3	1	4	4	1	4	4	4	0	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr22:40800432C>T	uc003ayu.1	+	5	548	c.339C>T	c.(337-339)GCC>GCT	p.A113A	SGSM3_uc010gyc.1_Silent_p.A113A|SGSM3_uc011aos.1_Silent_p.A46A|SGSM3_uc011aot.1_Silent_p.A50A|SGSM3_uc010gyd.1_Silent_p.A113A	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	113					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						TGGTGCTGGCCGGCATCCCAC	0.607													23	12					0	0	0	0	T	40800432	T	T	40800432	2	4	270	1	0	0	0	0	0	0	0	1	14289	639	23	1		1	SGSM3	22	40800432	Silent	SNP	C	TCGA-CV-7440-01A-11D-2129-08	42932	40800432	10504134	234	49122											
CELSR1	9620	broad.mit.edu	37	chr22	46806456	46806456	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagggccggtcagatccaggGacctgggtaggtaaagccat	10	6	16	9	1	1	1	1	0	0	1	2	3	2	2	4	5	1	2	4	5	3	2			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chr22:46806456G>A	uc003bhw.1	-	7	4772	c.4772C>T	c.(4771-4773)TCC>TTC	p.S1591F	CELSR1_uc011arc.1_5'Flank	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1591	Extracellular (Potential).|Laminin G-like 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CAGATCCAGGGACCTGGGTAG	0.642													32	26					0	0	0	0	A	46806456	A	A	46806456	3	1	270	1	0	0	0	0	1	0	0	0	3236	1174	41	2	4388	2	CELSR1	22	46806456	Missense_Mutation	SNP	G	TCGA-CV-7440-01A-11D-2129-08	6006024	46806456	4498110	235	49123											
FRMPD4	9758	broad.mit.edu	37	chrX	12734432	12734432	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcccggggaggccccctgTgaggcagactacagaagtct	9	5	14	13	1	1	3	0	1	1	2	1	4	1	4	3	4	2	1	3	4	2	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chrX:12734432T>A	uc004cuz.1	+	15	2360	c.1854T>A	c.(1852-1854)TGT>TGA	p.C618*	FRMPD4_uc011mij.1_Nonsense_Mutation_p.C610*	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	618					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGGCCCCCTGTGAGGCAGACT	0.532													47	30					0	0	0	0	A	12734432	A	A	12734432	4	1	270	1	0	0	0	0	0	1	0	0	6093	1702	59	5	1912	5	FRMPD4	23	12734432	Nonsense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08		12734432	142536128	236	49124											
HUWE1	10075	broad.mit.edu	37	chrX	53672318	53672318	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcttgtcagatcccagaCgagtgatgtagtttgatctt	8	15	9	9	1	3	4	1	2	2	2	5	5	5	4	2	0	0	2	2	0	1	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chrX:53672318C>G	uc004dsp.2	-	7	851	c.449G>C	c.(448-450)CGT>CCT	p.R150P		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	150					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGATCCCAGACGAGTGATGTA	0.458													16	14					0	0	0	0	G	53672318	G	G	53672318	3	3	270	1	0	0	0	0	1	0	0	0	7500	536	19	3	12987	3	HUWE1	23	53672318	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	40937886	53672318	101598242	237	49125											
HEPH	9843	broad.mit.edu	37	chrX	65480093	65480093	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagaccctcttcactgtttTttctcgaacaggtaagtcct	8	14	8	11	1	3	1	1	0	2	1	5	3	4	1	2	2	1	2	2	2	2	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chrX:65480093T>C	uc011moz.1	+	19	3257	c.3197T>C	c.(3196-3198)TTT>TCT	p.F1066S	HEPH_uc004dwn.2_Missense_Mutation_p.F1066S|HEPH_uc004dwo.2_Missense_Mutation_p.F796S|HEPH_uc010nkr.2_Missense_Mutation_p.F874S|HEPH_uc011mpa.1_Missense_Mutation_p.F1066S	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1063	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						TTCACTGTTTTTTCTCGAACA	0.473													17	12					0	0	0	0	C	65480093	C	C	65480093	3	2	270	1	0	0	0	0	1	0	0	0	7093	1841	64	5	3424	5	HEPH	23	65480093	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	11807775	65480093	89790467	238	49126											
ATRX	546	broad.mit.edu	37	chrX	76907828	76907828	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcttctttttcctcctcttCttcctcagaattactctaca	6	19	1	15	0	6	1	1	0	5	1	9	1	9	1	3	0	2	0	3	0	3	7			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chrX:76907828C>G	uc004ecp.3	-	15	4565	c.4333G>C	c.(4333-4335)GAA>CAA	p.E1445Q	ATRX_uc004ecq.3_Missense_Mutation_p.E1407Q|ATRX_uc004eco.3_Missense_Mutation_p.E1230Q	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1445	Poly-Glu.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	tcctcctcttcttcctcAGAA	0.199			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						22	21					0	0	0	0	G	76907828	G	G	76907828	3	3	270	1	0	0	0	0	1	0	0	0	1210	922	32	2	3229	2	ATRX	23	76907828	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	11427735	76907828	78362732	239	49127											
BEX4	56271	broad.mit.edu	37	chrX	102471104	102471104	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggagtccaaagaggaactagCggcaaacaatctcaacgggg	15	4	13	9	2	1	1	1	0	1	1	3	3	2	3	1	5	4	1	1	5	6	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chrX:102471104C>A	uc004ejv.3	+	3	258	c.23C>A	c.(22-24)GCG>GAG	p.A8E	BEX4_uc004ejw.3_Missense_Mutation_p.A8E	NM_001080425	NP_001073894	Q9NWD9	BEX4_HUMAN	BEX family member 4	8						cytoplasm|nucleus				skin(1)	1						GAGGAACTAGCGGCAAACAAT	0.512													20	21					7.21436e-19	9.631e-19	1	0	A	102471104	A	A	102471104	3	1	270	1	0	0	0	0	1	0	0	0	1415	768	27	3	25	3	BEX4	23	102471104	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	25563276	102471104	52799456	240	49128											
ACSL4	2182	broad.mit.edu	37	chrX	108904779	108904779	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttttggcaaaagcacagaTgttgtcaataagtggacaat	14	11	9	7	0	1	1	1	0	0	1	1	2	1	2	1	2	1	3	1	2	5	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chrX:108904779T>C	uc004eoi.2	-	15	2306	c.1801A>G	c.(1801-1803)ATC>GTC	p.I601V	ACSL4_uc004eoj.2_Missense_Mutation_p.I560V|ACSL4_uc004eok.2_Missense_Mutation_p.I560V	NM_022977	NP_075266	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	601	Cytoplasmic (Potential).				fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(1)|lung(1)|ovary(1)	3					Icosapent(DB00159)|Troglitazone(DB00197)	AAAGCACAGATGTTGTCAATA	0.333													22	19					0	0	0	0	C	108904779	C	C	108904779	3	2	270	1	0	0	0	0	1	0	0	0	179	1464	51	5	346	5	ACSL4	23	108904779	Missense_Mutation	SNP	T	TCGA-CV-7440-01A-11D-2129-08	6433675	108904779	46365781	241	49129											
ALG13	79868	broad.mit.edu	37	chrX	110951259	110951259	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcttcttttcacagggtcCtgacttgtcctgggcaagcc	5	13	9	14	0	3	1	1	1	2	0	5	1	5	1	4	2	1	1	4	2	1	4			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chrX:110951259C>G	uc011msy.1	+	4	422	c.388C>G	c.(388-390)CTG>GTG	p.L130V	ALG13_uc011msw.1_Missense_Mutation_p.L52V|ALG13_uc011msx.1_Missense_Mutation_p.L26V|ALG13_uc011msz.1_Missense_Mutation_p.L52V|ALG13_uc011mta.1_Missense_Mutation_p.L26V|ALG13_uc011mtb.1_Missense_Mutation_p.L26V			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	130					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						TCACAGGGTCCTGACTTGTCC	0.512													7	7					0	0	0	0	G	110951259	G	G	110951259	3	3	270	1	0	0	0	0	1	0	0	0	515	680	24	4	544	4	ALG13	23	110951259	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	2046480	110951259	44319301	242	49130											
TRPC5	7224	broad.mit.edu	37	chrX	111097062	111097062	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccctgtacatgaaggtcTgtcctgacaatgtgctgaga	9	10	12	10	0	1	3	0	3	1	1	2	4	2	3	3	2	2	2	3	2	3	1			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chrX:111097062T>A	uc004epl.1	-	4	2092	c.1173A>T	c.(1171-1173)ACA>ACT	p.T391T	TRPC5_uc004epm.1_Silent_p.T391T	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	391	Extracellular (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						CATGAAGGTCTGTCCTGACAA	0.483													46	28					0	0	0	0	A	111097062	A	A	111097062	2	1	270	1	0	0	0	0	0	0	0	1	16649	1567	55	5		5	TRPC5	23	111097062	Silent	SNP	T	TCGA-CV-7440-01A-11D-2129-08	145803	111097062	44173498	243	49131											
UBE2NL	389898	broad.mit.edu	37	chrX	142967322	142967322	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattttcatgtggtcattgcTggggaatcaaaggattcccc	9	14	10	8	0	3	0	3	0	0	0	4	2	4	2	2	4	1	1	2	4	3	5			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chrX:142967322T>A	uc004fca.2	+	1	150	c.120T>A	c.(118-120)GCT>GCA	p.A40A		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	40							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					TGGTCATTGCTGGGGAATCAA	0.473													53	35					0	0	0	0	A	142967322	A	A	142967322	2	1	270	1	0	0	0	0	0	0	0	1	16935	1567	55	5		5	UBE2NL	23	142967322	Silent	SNP	T	TCGA-CV-7440-01A-11D-2129-08	31870260	142967322	12303238	244	49132											
ATP2B3	492	broad.mit.edu	37	chrX	152807330	152807330	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatccggaacgggcagctcCtccaggtccccgtggctgcg	5	7	13	16	4	1	0	1	0	0	0	5	1	5	1	5	4	3	3	5	4	1	0			TCGA-CV-7440-01A-11D-2129-08	TCGA-CV-7440-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	901c2ed5-8348-4dd9-a84c-6c0b18d6525e	10c383d7-07ab-4de5-b6e3-e19dd22e0d47	g.chrX:152807330C>A	uc004fht.1	+	3	736	c.610C>A	c.(610-612)CTC>ATC	p.L204I	ATP2B3_uc004fhs.1_Missense_Mutation_p.L204I	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	204	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGGGCAGCTCCTCCAGGTCCC	0.622													61	27					3.07184e-27	4.26907e-27	1	0	A	152807330	A	A	152807330	3	1	270	1	0	0	0	0	1	0	0	0	1143	681	24	4	620	4	ATP2B3	23	152807330	Missense_Mutation	SNP	C	TCGA-CV-7440-01A-11D-2129-08	9840008	152807330	2463230	245	49133											
SAMD11	148398	broad.mit.edu	37	chr1	866467	866467	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctttccgagaggcgtcctgCaggtaggagccgtgctgtgc	5	10	15	11	3	1	1	0	0	1	1	3	3	3	2	3	3	4	3	3	3	1	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:866467C>T	uc001abw.1	+	4	383	c.303C>T	c.(301-303)TGC>TGT	p.C101C	SAMD11_uc001abv.1_Silent_p.C101C	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	101						nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		AGGCGTCCTGCAGGTAGGAGC	0.637													21	31					0	0	0	0	T	866467	T	T	866467	2	4	271	1	0	0	0	0	0	0	0	1	13881	718	25	4		4	SAMD11	1	866467	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08		866467	248384154	1	49134											
MIIP	60672	broad.mit.edu	37	chr1	12081875	12081875	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggatgctgtgcggcggtCagtggccagggcagcctcgg	5	6	19	11	3	1	0	1	0	0	0	2	1	1	1	2	6	3	3	2	6	0	0			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:12081875C>T	uc001ato.1	+	2	272	c.92C>T	c.(91-93)TCA>TTA	p.S31L		NM_021933	NP_068752	Q5JXC2	MIIP_HUMAN	invasion inhibitory protein 45	31										ovary(1)	1						GTGCGGCGGTCAGTGGCCAGG	0.612													5	27					0	0	0	0	T	12081875	T	T	12081875	3	4	271	1	0	0	0	0	1	0	0	0	9638	838	29	2	94	2	MIIP	1	12081875	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	11215408	12081875	237168746	2	49135											
USP48	84196	broad.mit.edu	37	chr1	22030033	22030033	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatccacaactttatggacaTagatggtggcttgagtgtat	11	14	10	6	0	0	2	0	1	0	1	1	3	1	3	1	3	1	2	1	3	5	6			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:22030033T>A	uc001bfb.2	-	21	2832	c.2594A>T	c.(2593-2595)TAT>TTT	p.Y865F	USP48_uc001bfa.2_Missense_Mutation_p.Y403F|USP48_uc010odq.1_Missense_Mutation_p.Y877F|USP48_uc009vqc.2_Missense_Mutation_p.Y799F|USP48_uc001bfc.2_Missense_Mutation_p.Y865F|USP48_uc001bfd.1_Intron	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	865					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		TTTATGGACATAGATGGTGGC	0.428													65	126					0	0	0	0	A	22030033	A	A	22030033	3	1	271	1	0	0	0	0	1	0	0	0	17147	1406	49	5	541	5	USP48	1	22030033	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	9948158	22030033	227220588	3	49136											
CPT2	1376	broad.mit.edu	37	chr1	53676319	53676319	+	Frame_Shift_Del	DEL	C	-	-																															tggactcggcagtgttctgtCtctgcctagatgacttcccc																										TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:53676319delC	uc001cvb.3	+	4	1488	c.973delC	c.(973-975)CTCfs	p.L325fs		NM_000098	NP_000089	P23786	CPT2_HUMAN	carnitine O-palmitoyltransferase precursor	325	Mitochondrial matrix (By similarity).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity				0					L-Carnitine(DB00583)|Perhexiline(DB01074)	AGTGTTCTGTCTCTGCCTAGA	0.512													---	---	---								-	53676319	-	-	53676319	7	5	271	1	0	1	0	1	0	0	0	0	3849	913	32	0	987	0	CPT2	1	53676319	Frame_Shift_Del	DEL	C	TCGA-CX-7082-01A-11D-2012-08	31646286	53676319	195574302	4	49137											
USP1	7398	broad.mit.edu	37	chr1	62907261	62907261	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatctcggcaatacttgctaTcttaatagtatacttcaggt	12	15	6	8	1	3	0	1	0	2	0	4	0	3	0	0	2	3	3	0	2	8	8			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:62907261T>C	uc001daj.1	+	3	601	c.273T>C	c.(271-273)TAT>TAC	p.Y91Y	USP1_uc001dak.1_Silent_p.Y91Y|USP1_uc001dal.1_Silent_p.Y91Y	NM_001017415	NP_001017415	O94782	UBP1_HUMAN	ubiquitin specific protease 1	91					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		ATACTTGCTATCTTAATAGTA	0.343													31	36					0	0	0	0	C	62907261	C	C	62907261	2	2	271	1	0	0	0	0	0	0	0	1	17108	1442	50	5		5	USP1	1	62907261	Silent	SNP	T	TCGA-CX-7082-01A-11D-2012-08	9230942	62907261	186343360	5	49138											
RWDD3	25950	broad.mit.edu	37	chr1	95710106	95710106	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggatgatggattgtggataaCtcttttgcatttagatcaca	11	15	10	5	0	2	2	1	1	1	1	2	5	2	5	0	3	2	1	0	3	2	6			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:95710106C>G	uc009wdu.2	+	2	501	c.425C>G	c.(424-426)ACT>AGT	p.T142S	RWDD3_uc001drd.3_3'UTR|RWDD3_uc010oty.1_Missense_Mutation_p.T127S|RWDD3_uc009wdt.2_Missense_Mutation_p.T142S|RWDD3_uc001drf.3_Missense_Mutation_p.T142S|RWDD3_uc001drh.3_Missense_Mutation_p.T127S|RWDD3_uc009wdv.2_Intron|RWDD3_uc001drg.3_RNA|RWDD3_uc001dri.3_Missense_Mutation_p.T142S	NM_015485	NP_056300	Q9Y3V2	RWDD3_HUMAN	RWD domain containing 3 isoform a	142						cytoplasm|nucleus	protein binding			ovary(1)	1		all_epithelial(167;5.99e-05)|all_lung(203;0.00168)|Lung NSC(277;0.00769)		all cancers(265;0.112)|Epithelial(280;0.229)		TTGTGGATAACTCTTTTGCAT	0.418													12	59					0	0	0	0	G	95710106	G	G	95710106	3	3	271	1	0	0	0	0	1	0	0	0	13822	565	20	4	431	4	RWDD3	1	95710106	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	32802845	95710106	153540515	6	49139											
COL11A1	1301	broad.mit.edu	37	chr1	103345461	103345461	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atggaatttccttcaacatcTaagtatgaaagctaggaata	16	12	7	6	0	2	1	1	1	1	0	3	3	3	3	1	2	2	2	1	2	8	6			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:103345461T>A	uc001dul.2	-	66	5370	c.5052A>T	c.(5050-5052)TTA>TTT	p.L1684F	COL11A1_uc001duk.2_Missense_Mutation_p.L880F|COL11A1_uc001dum.2_Missense_Mutation_p.L1696F|COL11A1_uc001dun.2_Missense_Mutation_p.L1645F|COL11A1_uc009weh.2_Missense_Mutation_p.L1568F	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1684	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTTCAACATCTAAGTATGAAA	0.378													11	23					0	0	0	0	A	103345461	A	A	103345461	3	1	271	1	0	0	0	0	1	0	0	0	3682	1519	53	5	376	5	COL11A1	1	103345461	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	7635355	103345461	145905160	7	49140											
PTGFRN	5738	broad.mit.edu	37	chr1	117484584	117484584	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgttaaggcggactgccaaCgacgccgtggagctccacat	9	7	12	13	4	0	0	0	0	0	0	1	3	1	2	3	3	3	2	3	3	2	1	rs149801733		TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:117484584C>T	uc001egv.1	+	2	434	c.297C>T	c.(295-297)AAC>AAT	p.N99N		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	99	Extracellular (Potential).|Ig-like C2-type 1.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GGACTGCCAACGACGCCGTGG	0.587													5	27					0	0	0	0	T	117484584	T	T	117484584	2	4	271	1	0	0	0	0	0	0	0	1	12813	535	19	1		1	PTGFRN	1	117484584	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08	14139123	117484584	131766037	8	49141											
NBPF9	400818	broad.mit.edu	37	chr1	144619881	144619881	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtcccacctggctcatcAgggaggtgcagaaggctgaa	9	8	13	11	0	3	2	2	1	1	1	4	3	4	3	2	4	1	3	2	4	2	0			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:144619881A>C	uc009wig.1	+	8	643	c.567_splice	c.e8-2	p.R189_splice	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Splice_Site_p.R189_splice|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Splice_Site_p.R120_splice|NBPF9_uc001eli.3_Splice_Site|NBPF9_uc010oyf.1_Splice_Site_p.R120_splice|NBPF9_uc010oyg.1_Splice_Site_p.R154_splice|NBPF9_uc009wii.1_Splice_Site	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818							cytoplasm					0						CTGGCTCATCAGGGAGGTGCA	0.522													17	800					0	0	0	0	C	144619881	C	C	144619881	5	2	271	1	0	0	0	0	0	0	1	0	10253	202	7	5	581	5	NBPF9	1	144619881	Splice_Site	SNP	A	TCGA-CX-7082-01A-11D-2012-08	27135297	144619881	104630740	9	49142											
BCL9	607	broad.mit.edu	37	chr1	147096739	147096739	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttagccaaggacctggcaaCccaggaaacatgatgtttta	13	10	9	9	0	0	1	0	1	0	0	0	3	0	3	3	3	3	2	3	3	5	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:147096739C>T	uc001epq.2	+	10	5000	c.4260C>T	c.(4258-4260)AAC>AAT	p.N1420N	BCL9_uc010ozr.1_Silent_p.N1334N	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1420					Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					GACCTGGCAACCCAGGAAACA	0.542			T	IGH@|IGL@	B-ALL								18	15					0	0	0	0	T	147096739	T	T	147096739	2	4	271	1	0	0	0	0	0	0	0	1	1383	506	18	4		4	BCL9	1	147096739	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08	2476858	147096739	102153882	10	49143											
DCAF6	55827	broad.mit.edu	37	chr1	167973999	167973999	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaacaaaggcagtctgttgAggcatctggacaccacacac	13	7	10	11	0	2	2	0	2	2	0	2	3	2	3	1	3	1	3	1	3	2	1			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:167973999A>T	uc001gew.2	+	10	1588	c.1346A>T	c.(1345-1347)GAG>GTG	p.E449V	DCAF6_uc001gev.2_Missense_Mutation_p.E449V|DCAF6_uc001gex.2_Missense_Mutation_p.E449V|DCAF6_uc010plk.1_Missense_Mutation_p.E418V|DCAF6_uc001gey.2_Missense_Mutation_p.E302V	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	449					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CAGTCTGTTGAGGCATCTGGA	0.373													36	14					0	0	0	0	T	167973999	T	T	167973999	3	4	271	1	0	0	0	0	1	0	0	0	4291	304	11	5	1384	5	DCAF6	1	167973999	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	20877260	167973999	81276622	11	49144											
ZBTB37	84614	broad.mit.edu	37	chr1	173839375	173839375	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcacgaccatggagaaaggTgggaacatacaattggagat	15	6	14	6	1	0	2	0	0	0	2	0	6	0	3	1	5	2	1	1	5	4	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:173839375T>C	uc009wwp.1	+	3	288	c.12T>C	c.(10-12)GGT>GGC	p.G4G	GAS5_uc001gjj.2_5'Flank|GAS5_uc001gjk.2_5'Flank|SNORD74_uc001gjo.1_5'Flank|ZBTB37_uc001gjp.1_Silent_p.G4G|ZBTB37_uc001gjq.3_Silent_p.G4G|ZBTB37_uc001gjr.2_Silent_p.G4G	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGGAGAAAGGTGGGAACATAC	0.443													16	22					0	0	0	0	C	173839375	C	C	173839375	2	2	271	1	0	0	0	0	0	0	0	1	17605	1683	59	5		5	ZBTB37	1	173839375	Silent	SNP	T	TCGA-CX-7082-01A-11D-2012-08	5865376	173839375	75411246	12	49145											
EPRS	2058	broad.mit.edu	37	chr1	220206926	220206926	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcagagacaggcaatgattGagttcattaattgtagaagt	14	12	10	5	0	2	4	2	2	0	2	2	5	2	4	0	1	0	3	0	1	4	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:220206926G>C	uc001hly.1	-	4	576	c.306C>G	c.(304-306)CTC>CTG	p.L102L	EPRS_uc010puf.1_5'UTR|EPRS_uc001hlz.1_Silent_p.L102L|EPRS_uc009xdt.1_5'UTR	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	102					glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	GGCAATGATTGAGTTCATTAA	0.343													20	77					0	0	0	0	C	220206926	C	C	220206926	2	2	271	1	0	0	0	0	0	0	0	1	5215	1277	45	2		2	EPRS	1	220206926	Silent	SNP	G	TCGA-CX-7082-01A-11D-2012-08	46367551	220206926	29043695	13	49146											
DISP1	84976	broad.mit.edu	37	chr1	223179194	223179194	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcacaaagttgtggcagAattgtgagagtgaagtgcaa	15	10	12	4	0	1	3	1	2	0	2	1	4	1	3	0	1	1	3	0	1	5	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:223179194A>G	uc001hnu.1	+	8	4602	c.4455A>G	c.(4453-4455)AGA>AGG	p.R1485R		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1485					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		GTTGTGGCAGAATTGTGAGAG	0.408													12	61					0	0	0	0	G	223179194	G	G	223179194	2	3	271	1	0	0	0	0	0	0	0	1	4561	243	9	5		5	DISP1	1	223179194	Silent	SNP	A	TCGA-CX-7082-01A-11D-2012-08	2972268	223179194	26071427	14	49147											
LYST	1130	broad.mit.edu	37	chr1	235860530	235860530	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagcactgggggaacccaCgtattccccccatttcaagc	9	8	10	14	1	1	0	1	0	0	0	2	2	2	2	4	3	3	2	4	3	3	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr1:235860530C>T	uc001hxj.2	-	46	10592	c.10417G>A	c.(10417-10419)GTG>ATG	p.V3473M	LYST_uc001hxi.2_Missense_Mutation_p.V697M	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3473					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GGGGAACCCACGTATTCCCCC	0.468									Chediak-Higashi_syndrome				50	13					0	0	0	0	T	235860530	T	T	235860530	3	4	271	1	0	0	0	0	1	0	0	0	9179	536	19	1	1020	1	LYST	1	235860530	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	12681336	235860530	13390091	15	49148											
COLEC11	78989	broad.mit.edu	37	chr2	3691423	3691423	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggccgcgggggcacgctGagcatgcccaaggacgaggc	8	2	18	13	4	0	1	0	1	0	0	0	3	0	2	2	5	2	3	2	5	1	0			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr2:3691423G>T	uc002qya.2	+	7	679	c.531G>T	c.(529-531)CTG>CTT	p.L177L	COLEC11_uc002qxz.2_Silent_p.L174L|COLEC11_uc002qyb.2_Silent_p.L153L|COLEC11_uc002qyc.2_Silent_p.L153L|COLEC11_uc010ewo.2_Silent_p.L129L|COLEC11_uc010ewp.2_Silent_p.L151L|COLEC11_uc010ewq.2_Silent_p.L127L|COLEC11_uc010ewr.2_Silent_p.L127L|COLEC11_uc010ews.2_Silent_p.L103L	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	177	C-type lectin.					collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		GGGGCACGCTGAGCATGCCCA	0.667													19	26					1.01871e-10	3.59945e-10	1	0	T	3691423	T	T	3691423	2	4	271	1	0	0	0	0	0	0	0	1	3726	1277	45	2		2	COLEC11	2	3691423	Silent	SNP	G	TCGA-CX-7082-01A-11D-2012-08		3691423	239507950	16	49149											
KCNS3	3790	broad.mit.edu	37	chr2	18112633	18112633	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgattcttgctgcagcaatCgctaccaggaacgcaaggag	11	9	11	10	2	1	1	0	1	1	0	2	3	1	3	1	2	5	5	1	2	4	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr2:18112633C>T	uc002rcv.2	+	3	809	c.358C>T	c.(358-360)CGC>TGC	p.R120C	KCNS3_uc002rcw.2_Missense_Mutation_p.R120C	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	120	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTGCAGCAATCGCTACCAGGA	0.507													15	78					0	0	0	0	T	18112633	T	T	18112633	3	4	271	1	0	0	0	0	1	0	0	0	8129	884	31	1	360	1	KCNS3	2	18112633	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	14421210	18112633	225086740	17	49150											
ALK	238	broad.mit.edu	37	chr2	29456487	29456487	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcctgcccactcatgcaCgcttctgttcacacggattt	6	12	7	16	2	3	0	2	0	1	0	4	1	4	1	3	1	2	3	3	1	0	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr2:29456487C>A	uc002rmy.2	-	14	3338	c.2431G>T	c.(2431-2433)GTG>TTG	p.V811L		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	811	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CACTCATGCACGCTTCTGTTC	0.488			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				35	61					1.26612e-14	4.62788e-14	1	0	A	29456487	A	A	29456487	3	1	271	1	0	0	0	0	1	0	0	0	525	536	19	3	2495	3	ALK	2	29456487	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	11343854	29456487	213742886	18	49151											
C2orf65	130951	broad.mit.edu	37	chr2	74802648	74802648	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccaacagcttgtaggtcTgaggatgaacgggagtccat	10	9	13	9	1	1	2	0	2	1	0	2	4	2	4	2	3	4	2	2	3	3	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr2:74802648T>A	uc002smy.2	-	7	1108	c.991A>T	c.(991-993)AGA>TGA	p.R331*	C2orf65_uc010ysa.1_Nonsense_Mutation_p.R331*|C2orf65_uc002smz.2_Nonsense_Mutation_p.R331*|C2orf65_uc010ffp.2_Nonsense_Mutation_p.R49*|C2orf65_uc002smx.2_Nonsense_Mutation_p.R87*	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	331					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						CTTGTAGGTCTGAGGATGAAC	0.483													40	64					0	0	0	0	A	74802648	A	A	74802648	4	1	271	1	0	0	0	0	0	1	0	0	2194	1588	55	5	621	5	C2orf65	2	74802648	Nonsense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	45346161	74802648	168396725	19	49152											
LRRTM1	347730	broad.mit.edu	37	chr2	80529787	80529787	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtggtggccgagctggcaggGggccccagatcactgcggtt	5	7	18	11	2	1	1	1	0	0	1	1	2	1	1	3	6	2	3	3	6	0	1			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr2:80529787G>T	uc002sok.1	-	2	1428	c.1158C>A	c.(1156-1158)CCC>CCA	p.P386P	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	386	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						AGCTGGCAGGGGGCCCCAGAT	0.726										HNSCC(69;0.2)			9	20					9.70103e-10	3.3715e-09	1	0	T	80529787	T	T	80529787	2	4	271	1	0	0	0	0	0	0	0	1	9089	1219	43	4		4	LRRTM1	2	80529787	Silent	SNP	G	TCGA-CX-7082-01A-11D-2012-08	5727139	80529787	162669586	20	49153											
SH3RF3	344558	broad.mit.edu	37	chr2	110015122	110015122	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccagctgcaatgcctcccTgccctctgactccggcgctg	5	9	9	18	2	1	1	0	1	1	0	4	1	4	1	5	1	4	3	5	1	1	0			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr2:110015122T>G	uc010ywt.1	+	4	1022	c.1022T>G	c.(1021-1023)CTG>CGG	p.L341R		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	341							zinc ion binding			ovary(1)	1						AATGCCTCCCTGCCCTCTGAC	0.617													3	7					0	0	0	0	G	110015122	G	G	110015122	3	3	271	1	0	0	0	0	1	0	0	0	14325	1580	55	5	1036	5	SH3RF3	2	110015122	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	29485335	110015122	133184251	21	49154											
KIAA1715	80856	broad.mit.edu	37	chr2	176794733	176794733	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctccacttagttcaggatCaggaatagaatcagctccag	12	11	8	10	0	4	1	3	0	1	1	6	3	5	3	2	2	1	2	2	2	4	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr2:176794733C>A	uc002ukc.1	-	13	1442	c.1249G>T	c.(1249-1251)GAT>TAT	p.D417Y	KIAA1715_uc010zer.1_Missense_Mutation_p.D448Y|KIAA1715_uc010fqw.1_Missense_Mutation_p.D483Y|KIAA1715_uc010zes.1_Missense_Mutation_p.D419Y|KIAA1715_uc002ukd.1_Missense_Mutation_p.D294Y|KIAA1715_uc010zet.1_RNA	NM_030650	NP_085153	Q9C0E8	LNP_HUMAN	Lunapark	417	Cytoplasmic (Potential).					integral to membrane	protein binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0793)			AGTTCAGGATCAGGAATAGAA	0.428													24	61					1.64293e-13	5.95388e-13	1	0	A	176794733	A	A	176794733	3	1	271	1	0	0	0	0	1	0	0	0	8293	826	29	2	41	2	KIAA1715	2	176794733	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	66779611	176794733	66404640	22	49155											
KIAA1715	80856	broad.mit.edu	37	chr2	176794780	176794780	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagttggtttcaatcactGaggcttcctcattctcagtc	7	15	9	10	0	4	1	4	1	1	0	7	2	5	2	1	3	0	3	1	3	1	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr2:176794780G>A	uc002ukc.1	-	13	1395	c.1202C>T	c.(1201-1203)TCA>TTA	p.S401L	KIAA1715_uc010zer.1_Missense_Mutation_p.S432L|KIAA1715_uc010fqw.1_Missense_Mutation_p.S467L|KIAA1715_uc010zes.1_Missense_Mutation_p.S403L|KIAA1715_uc002ukd.1_Missense_Mutation_p.S278L|KIAA1715_uc010zet.1_RNA	NM_030650	NP_085153	Q9C0E8	LNP_HUMAN	Lunapark	401	Cytoplasmic (Potential).					integral to membrane	protein binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0793)			TTCAATCACTGAGGCTTCCTC	0.438													35	59					0	0	0	0	A	176794780	A	A	176794780	3	1	271	1	0	0	0	0	1	0	0	0	8293	1294	45	2	88	2	KIAA1715	2	176794780	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	47	176794780	66404593	23	49156											
TMEFF2	23671	broad.mit.edu	37	chr2	193049123	193049123	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accacaagtatctcactctgCtgtttgcatgcagcctgtcg	8	12	8	13	1	2	0	1	0	2	0	4	0	2	0	2	0	4	5	2	0	2	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr2:193049123C>T	uc002utc.2	-	3	763	c.369G>A	c.(367-369)CAG>CAA	p.Q123Q	TMEFF2_uc002utd.1_Silent_p.Q123Q	NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	123	Kazal-like 1.|Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			TCTCACTCTGCTGTTTGCATG	0.473													25	43					0	0	0	0	T	193049123	T	T	193049123	2	4	271	1	0	0	0	0	0	0	0	1	16080	796	28	4		4	TMEFF2	2	193049123	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08	16254343	193049123	50150250	24	49157											
DOCK10	55619	broad.mit.edu	37	chr2	225653885	225653885	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccatcccatagagaacaTgccttgggaggaccaagcag	12	6	12	11	0	0	1	0	0	0	1	1	4	1	3	4	3	3	1	4	3	3	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr2:225653885T>A	uc010fwz.1	-	48	5553	c.5314A>T	c.(5314-5316)ATG>TTG	p.M1772L	DOCK10_uc002vob.2_Missense_Mutation_p.M1766L|DOCK10_uc002voa.2_Missense_Mutation_p.M428L|DOCK10_uc002voc.2_Missense_Mutation_p.M593L	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1772	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		ATAGAGAACATGCCTTGGGAG	0.373													5	19					0	0	0	0	A	225653885	A	A	225653885	3	1	271	1	0	0	0	0	1	0	0	0	4707	1464	51	5	1282	5	DOCK10	2	225653885	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	32604762	225653885	17545488	25	49158											
OXSM	54995	broad.mit.edu	37	chr3	25832618	25832618	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtttttcggaactgtgcCaatatccagattgcataggc	11	12	10	8	1	0	1	0	0	0	1	2	3	1	2	2	2	3	2	2	2	5	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr3:25832618C>A	uc003cdn.2	+	2	214	c.107C>A	c.(106-108)CCA>CAA	p.P36Q	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_5'UTR|OXSM_uc010hfh.2_Missense_Mutation_p.P36Q	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	36					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						GGAACTGTGCCAATATCCAGA	0.423													46	32					4.06502e-11	1.44838e-10	1	0	A	25832618	A	A	25832618	3	1	271	1	0	0	0	0	1	0	0	0	11389	594	21	4	109	4	OXSM	3	25832618	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08		25832618	172189812	26	49159											
CHDH	55349	broad.mit.edu	37	chr3	53854579	53854579	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaatggagggtgatagggcGggtgcatgcctgctgaatgt	8	10	18	5	1	0	3	0	3	0	0	0	4	0	4	1	4	3	2	1	4	3	1			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr3:53854579G>A	uc003dgz.2	-	6	1482	c.1042C>T	c.(1042-1044)CGC>TGC	p.R348C		NM_018397	NP_060867	Q8NE62	CHDH_HUMAN	choline dehydrogenase precursor	348					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			ovary(1)|central_nervous_system(1)	2		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	GTGATAGGGCGGGTGCATGCC	0.557													18	72					0	0	0	0	A	53854579	A	A	53854579	3	1	271	1	0	0	0	0	1	0	0	0	3348	1116	39	1	758	1	CHDH	3	53854579	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	28021961	53854579	144167851	27	49160											
GRAMD1C	54762	broad.mit.edu	37	chr3	113664258	113664258	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttacagctgaagagctcacTcattatgcttcagaaaacgt	13	12	7	9	1	3	3	3	1	0	2	3	3	3	3	0	0	5	3	0	0	5	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr3:113664258T>G	uc003eaq.3	+	18	1998	c.1922T>G	c.(1921-1923)CTC>CGC	p.L641R	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc003ear.2_Missense_Mutation_p.L474R|GRAMD1C_uc003eas.2_Missense_Mutation_p.L436R|GRAMD1C_uc003eat.2_Missense_Mutation_p.L300R|ZDHHC23_uc003eau.2_5'Flank|ZDHHC23_uc003eav.2_5'Flank	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	641						integral to membrane				ovary(2)|skin(1)	3						AAGAGCTCACTCATTATGCTT	0.323													24	50					0	0	0	0	G	113664258	G	G	113664258	3	3	271	1	0	0	0	0	1	0	0	0	6788	1551	54	5	1992	5	GRAMD1C	3	113664258	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	59809679	113664258	84358172	28	49161											
KALRN	8997	broad.mit.edu	37	chr3	124211627	124211627	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaggagtggatcaagaacaTtcgagaagtgattcaagaaa	17	7	12	5	1	2	4	2	1	0	3	3	7	2	6	0	2	1	1	0	2	5	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr3:124211627T>A	uc003ehg.2	+	32	4851	c.4724T>A	c.(4723-4725)ATT>AAT	p.I1575N	KALRN_uc010hrv.1_Missense_Mutation_p.I1566N|KALRN_uc003ehf.1_Missense_Mutation_p.I1575N|KALRN_uc011bjy.1_Missense_Mutation_p.I1566N	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1575	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ATCAAGAACATTCGAGAAGTG	0.463													24	46					0	0	0	0	A	124211627	A	A	124211627	3	1	271	1	0	0	0	0	1	0	0	0	8014	1493	52	5	4850	5	KALRN	3	124211627	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	10547369	124211627	73810803	29	49162											
OSBPL11	114885	broad.mit.edu	37	chr3	125271261	125271261	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgggtggaagaactgctaAaaacactggatgctacctcg	12	8	11	10	1	0	1	0	0	0	1	1	3	0	3	2	3	5	2	2	3	6	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr3:125271261A>G	uc003eic.2	-	9	2155	c.1418T>C	c.(1417-1419)TTT>TCT	p.F473S		NM_022776	NP_073613	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	473					lipid transport		lipid binding			ovary(3)|breast(1)|kidney(1)	5						AGAACTGCTAAAAACACTGGA	0.453													15	27					0	0	0	0	G	125271261	G	G	125271261	3	3	271	1	0	0	0	0	1	0	0	0	11330	14	1	5	845	5	OSBPL11	3	125271261	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	1059634	125271261	72751169	30	49163											
PLSCR1	5359	broad.mit.edu	37	chr3	146251261	146251261	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcagcaactgctttaccttgGaatgctgtcggtggatactg	8	13	11	9	1	1	0	1	0	0	0	2	2	1	2	1	3	6	3	1	3	4	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr3:146251261G>C	uc003evx.3	-	3	478	c.90C>G	c.(88-90)TTC>TTG	p.F30L	PLSCR1_uc003evy.3_Missense_Mutation_p.F23L|PLSCR1_uc011bnn.1_Missense_Mutation_p.S22C|PLSCR1_uc003evz.3_RNA|PLSCR1_uc003ewa.2_Missense_Mutation_p.F30L	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	30	Cytoplasmic.				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						CTTTACCTTGGAATGCTGTCG	0.294													24	92					0	0	0	0	C	146251261	C	C	146251261	3	2	271	1	0	0	0	0	1	0	0	0	12164	1165	41	2	894	2	PLSCR1	3	146251261	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	20980000	146251261	51771169	31	49164											
AGTR1	185	broad.mit.edu	37	chr3	148458977	148458977	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacagcttggtggtgatagTcatttacttttatatgaagc	12	15	9	5	0	1	2	1	2	0	0	1	2	1	2	0	2	4	1	0	2	6	7	rs150629733	byFrequency	TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr3:148458977T>C	uc003ewg.2	+	4	601	c.155T>C	c.(154-156)GTC>GCC	p.V52A	AGTR1_uc003ewh.2_Missense_Mutation_p.V52A|AGTR1_uc003ewi.2_Missense_Mutation_p.V52A|AGTR1_uc003ewj.2_Missense_Mutation_p.V52A|AGTR1_uc003ewk.2_Missense_Mutation_p.V52A	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	52	Helical; Name=1; (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	GTGGTGATAGTCATTTACTTT	0.378													20	73					0	0	0	0	C	148458977	C	C	148458977	3	2	271	1	0	0	0	0	1	0	0	0	401	1667	58	5	157	5	AGTR1	3	148458977	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	2207716	148458977	49563453	32	49165											
PHC3	80012	broad.mit.edu	37	chr3	169824653	169824653	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatagtgcagaatcgttttGaccgcaaaaattcattagca	15	11	7	8	2	1	2	1	1	0	1	2	2	1	2	1	0	2	4	1	0	5	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr3:169824653G>T	uc010hws.1	-	12	2463	c.2399C>A	c.(2398-2400)TCA>TAA	p.S800*	PHC3_uc003fgl.2_Nonsense_Mutation_p.S812*|PHC3_uc011bpq.1_Nonsense_Mutation_p.S759*	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	polyhomeotic like 3	800	FCS-type.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GAATCGTTTTGACCGCAAAAA	0.373													13	124					9.31168e-06	3.13345e-05	1	0	T	169824653	T	T	169824653	4	4	271	1	0	0	0	0	0	1	0	0	11873	1294	45	2	568	2	PHC3	3	169824653	Nonsense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	21365676	169824653	28197777	33	49166											
PIK3CA	5290	broad.mit.edu	37	chr3	178921501	178921501	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacatctacaaaatccctttGggttataaatagtgcactca	15	12	5	9	0	2	0	1	0	1	0	3	0	3	0	1	1	3	2	1	1	8	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr3:178921501G>C	uc003fjk.2	+	5	1140	c.983G>C	c.(982-984)TGG>TCG	p.W328S		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	328					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AAATCCCTTTGGGTTATAAAT	0.358		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			28	328					0	0	0	0	C	178921501	C	C	178921501	3	2	271	1	0	0	0	0	1	0	0	0	11968	1357	47	4	997	4	PIK3CA	3	178921501	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	9096848	178921501	19100929	34	49167											
HRG	3273	broad.mit.edu	37	chr3	186395211	186395211	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccatgcacaccatcctcatGaacatgatacccatagacag	14	7	5	15	0	1	3	1	2	0	1	2	3	2	3	4	0	3	1	4	0	3	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr3:186395211G>T	uc003fqq.2	+	7	1140	c.1117G>T	c.(1117-1119)GAA>TAA	p.E373*		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	373	His/Pro-rich (HRR).				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		ccatcctcatgaacatgatac	0.045													29	10					1.77063e-15	6.58551e-15	1	0	T	186395211	T	T	186395211	4	4	271	1	0	0	0	0	0	1	0	0	7393	1291	45	2	1143	2	HRG	3	186395211	Nonsense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	7473710	186395211	11627219	35	49168											
THAP6	152815	broad.mit.edu	37	chr4	76442145	76442145	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctccaaatattaaactgaaaCctggagtcataccttctatc	14	12	4	11	0	2	1	1	1	1	0	4	2	3	2	3	1	3	0	3	1	7	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr4:76442145C>T	uc003him.2	+	3	341	c.244C>T	c.(244-246)CCT>TCT	p.P82S	RCHY1_uc003hij.2_5'Flank|RCHY1_uc003hik.2_5'Flank|RCHY1_uc003hil.2_5'Flank|RCHY1_uc010iip.2_5'Flank|RCHY1_uc010iiq.2_5'Flank|RCHY1_uc010iir.2_5'Flank|THAP6_uc010iis.1_Missense_Mutation_p.P41S|THAP6_uc003hin.2_Missense_Mutation_p.P82S|THAP6_uc011cbm.1_Missense_Mutation_p.P82S|THAP6_uc010iiu.1_RNA|THAP6_uc003hio.1_RNA|THAP6_uc010iiv.2_Missense_Mutation_p.P82S	NM_144721	NP_653322	Q8TBB0	THAP6_HUMAN	THAP domain containing 6	82	THAP-type.					microtubule cytoskeleton	DNA binding|metal ion binding				0			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TAAACTGAAACCTGGAGTCAT	0.363													5	33					0	0	0	0	T	76442145	T	T	76442145	3	4	271	1	0	0	0	0	1	0	0	0	15914	507	18	4	250	4	THAP6	4	76442145	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08		76442145	114712131	36	49169											
C4orf29	80167	broad.mit.edu	37	chr4	128951815	128951815	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtgcttatctttttaaacAaggactcttcaggtaagacg	12	14	8	7	1	3	1	1	0	2	1	3	2	3	2	0	2	2	2	0	2	6	7			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr4:128951815A>T	uc003ifr.2	+	12	1547	c.1229A>T	c.(1228-1230)CAA>CTA	p.Q410L	C4orf29_uc003ifs.2_Missense_Mutation_p.Q338L|C4orf29_uc003ift.2_Missense_Mutation_p.Q275L|C4orf29_uc003ifu.2_Missense_Mutation_p.Q275L|C4orf29_uc010inz.2_Missense_Mutation_p.Q241L|C4orf29_uc003ifv.2_Missense_Mutation_p.Q275L	NM_001039717	NP_001034806	Q0P651	CD029_HUMAN	hypothetical protein LOC80167 precursor	410						extracellular region				ovary(1)	1						CTTTTTAAACAAGGACTCTTC	0.353													25	36					0	0	0	0	T	128951815	T	T	128951815	3	4	271	1	0	0	0	0	1	0	0	0	2269	130	5	5	1267	5	C4orf29	4	128951815	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	52509670	128951815	62202461	37	49170											
CDKN2AIP	55602	broad.mit.edu	37	chr4	184368144	184368144	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caatgaagatgtgaaacagaAgcaaccttttttcaatagac	17	10	7	7	0	1	5	1	2	0	3	1	5	1	5	1	0	3	1	1	0	7	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr4:184368144A>G	uc003ivp.1	+	3	1469	c.1307A>G	c.(1306-1308)AAG>AGG	p.K436R	CDKN2AIP_uc003ivq.1_Missense_Mutation_p.K181R	NM_017632	NP_060102	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	436					negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding				0		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GTGAAACAGAAGCAACCTTTT	0.408													24	38					0	0	0	0	G	184368144	G	G	184368144	3	3	271	1	0	0	0	0	1	0	0	0	3177	72	3	5	1317	5	CDKN2AIP	4	184368144	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	55416329	184368144	6786132	38	49171											
FAT1	2195	broad.mit.edu	37	chr4	187540589	187540589	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaagagtggtggattatcaTtgaggtcggtaacgtccacc	11	10	12	8	2	1	2	1	1	0	1	3	3	2	3	2	4	1	1	2	4	3	3	rs139480903	by1000genomes	TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr4:187540589T>C	uc003izf.2	-	10	7339	c.7151A>G	c.(7150-7152)AAT>AGT	p.N2384S		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2384	Extracellular (Potential).|Cadherin 21.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGGATTATCATTGAGGTCGGT	0.502										HNSCC(5;0.00058)			18	39					0	0	0	0	C	187540589	C	C	187540589	3	2	271	1	0	0	0	0	1	0	0	0	5721	1493	52	5	6687	5	FAT1	4	187540589	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	3172445	187540589	3613687	39	49172											
SLC6A18	348932	broad.mit.edu	37	chr5	1244337	1244337	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactgccccagggctggtcTgcctggtctgcttcctctcc	2	11	10	18	0	3	0	0	0	3	0	5	0	4	0	6	3	3	2	6	3	0	1			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr5:1244337T>C	uc003jby.1	+	10	1468	c.1345T>C	c.(1345-1347)TGC>CGC	p.C449R		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	449	Helical; Name=9; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AGGGCTGGTCTGCCTGGTCTG	0.627													26	37					0	0	0	0	C	1244337	C	C	1244337	3	2	271	1	0	0	0	0	1	0	0	0	14745	1580	55	5	1383	5	SLC6A18	5	1244337	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08		1244337	179670923	40	49173											
C5orf34	375444	broad.mit.edu	37	chr5	43506112	43506112	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctttgtaccaggcgaaggcaGctcttccctcccttcagttc	6	12	8	15	1	2	0	1	0	1	0	5	1	4	0	3	2	2	4	3	2	2	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr5:43506112G>C	uc003jnz.1	-	5	987	c.670C>G	c.(670-672)CTG>GTG	p.L224V	C5orf34_uc011cpx.1_Missense_Mutation_p.L110V	NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	224										breast(1)	1	Lung NSC(6;2.07e-05)					GGCGAAGGCAGCTCTTCCCTC	0.423													50	88					0	0	0	0	C	43506112	C	C	43506112	3	2	271	1	0	0	0	0	1	0	0	0	2303	962	34	4	1286	4	C5orf34	5	43506112	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	42261775	43506112	137409148	41	49174											
ZNF366	167465	broad.mit.edu	37	chr5	71756463	71756463	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctgagctgcttgaagagcttCccgcagtgcgtgcacgcgtg	6	9	14	12	4	0	3	0	2	0	1	1	3	1	3	1	0	5	5	1	0	1	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr5:71756463C>G	uc003kce.1	-	2	1047	c.861G>C	c.(859-861)GGG>GGC	p.G287G		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	287	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		TGAAGAGCTTCCCGCAGTGCG	0.627													23	50					0	0	0	0	G	71756463	G	G	71756463	2	3	271	1	0	0	0	0	0	0	0	1	17937	842	30	2		2	ZNF366	5	71756463	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08	28250351	71756463	109158797	42	49175											
PCDHA10	56139	broad.mit.edu	37	chr5	140237238	140237238	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgctacagttccaggtgagCgcgcgcgatgggggcgtgcc	5	7	17	12	5	0	1	0	1	0	0	1	2	1	1	2	3	4	2	2	3	1	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr5:140237238C>T	uc003lhx.2	+	1	1605	c.1605C>T	c.(1603-1605)AGC>AGT	p.S535S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Silent_p.S535S	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	535	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAGGTGAGCGCGCGCGATG	0.682													54	39					0	0	0	0	T	140237238	T	T	140237238	2	4	271	1	0	0	0	0	0	0	0	1	11574	767	27	1		1	PCDHA10	5	140237238	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08	68480775	140237238	40678022	43	49176											
PCDHB4	56131	broad.mit.edu	37	chr5	140502789	140502789	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagaatttttacaccctggtAacagagagaccactggaccg	14	8	9	10	1	0	3	0	0	0	3	0	5	0	4	3	2	2	1	3	2	4	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr5:140502789A>T	uc003lip.1	+	1	1209	c.1209A>T	c.(1207-1209)GTA>GTT	p.V403V		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	403	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGGTAACAGAGAGAC	0.448													32	19					0	0	0	0	T	140502789	T	T	140502789	2	4	271	1	0	0	0	0	0	0	0	1	11598	349	13	5		5	PCDHB4	5	140502789	Silent	SNP	A	TCGA-CX-7082-01A-11D-2012-08	265551	140502789	40412471	44	49177											
HSPA1A	3303	broad.mit.edu	37	chr6	31785354	31785354	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtgtgtaaccccatcatCagcggactgtaccagggtgc	9	8	12	12	1	2	0	2	0	0	0	2	1	2	1	3	3	4	2	3	3	2	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr6:31785354C>T	uc003nxj.2	+	1	2064	c.1821C>T	c.(1819-1821)ATC>ATT	p.I607I	HSPA1L_uc003nxh.2_5'Flank|HSPA1L_uc010jte.2_5'Flank|HSPA1A_uc011doj.1_Silent_p.I370I|HSPA1A_uc003nxi.1_Silent_p.I442I|uc011dok.1_RNA	NM_005345	NP_005336	P08107	HSP71_HUMAN	heat shock 70kDa protein 1A	607					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			ovary(1)	1						ACCCCATCATCAGCGGACTGT	0.632													30	82					0	0	0	0	T	31785354	T	T	31785354	2	4	271	1	0	0	0	0	0	0	0	1	7447	816	29	2		2	HSPA1A	6	31785354	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08		31785354	139329713	45	49178											
RTN4IP1	84816	broad.mit.edu	37	chr6	107031256	107031256	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaacatgggccactggccaTgaaaaatgcccagcgataat	15	7	9	10	1	0	1	0	1	0	0	0	2	0	1	3	2	3	0	3	2	5	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr6:107031256T>C	uc003prj.2	-	8	1507	c.1030A>G	c.(1030-1032)ATG>GTG	p.M344V	RTN4IP1_uc010kdd.2_Silent_p.S220S|RTN4IP1_uc003prk.2_Missense_Mutation_p.M244V	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	344						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		CCACTGGCCATGAAAAATGCC	0.413													20	28					0	0	0	0	C	107031256	C	C	107031256	3	2	271	1	0	0	0	0	1	0	0	0	13794	1464	51	5	168	5	RTN4IP1	6	107031256	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	75245902	107031256	64083811	46	49179											
MACC1	346389	broad.mit.edu	37	chr7	20198105	20198105	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctggttgtaaagacactatCtgacataaacattacttgct	13	14	6	8	0	2	2	0	1	2	1	2	2	2	2	0	1	3	3	0	1	6	6			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr7:20198105C>T	uc003sus.3	-	5	2188	c.1879G>A	c.(1879-1881)GAT>AAT	p.D627N	MACC1_uc010kug.2_Missense_Mutation_p.D627N	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	627					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						AAGACACTATCTGACATAAAC	0.353													33	76					0	0	0	0	T	20198105	T	T	20198105	3	4	271	1	0	0	0	0	1	0	0	0	9194	913	32	2	691	2	MACC1	7	20198105	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08		20198105	138940558	47	49180											
ZNF107	51427	broad.mit.edu	37	chr7	64166764	64166764	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acataaaagattctttccagAaagtgacactgagaagatac	18	9	7	7	0	1	5	0	2	1	4	2	6	2	5	1	0	1	0	1	0	5	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr7:64166764A>G	uc003ttd.2	+	7	868	c.82A>G	c.(82-84)AAA>GAA	p.K28E	ZNF107_uc003tte.2_Missense_Mutation_p.K28E	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TTCTTTCCAGAAAGTGACACT	0.363													26	25					0	0	0	0	G	64166764	G	G	64166764	3	3	271	1	0	0	0	0	1	0	0	0	17782	247	9	5	88	5	ZNF107	7	64166764	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	43968659	64166764	94971899	48	49181											
SMURF1	57154	broad.mit.edu	37	chr7	98638089	98638089	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccccagcagctgcttgtagaAgggcactgtgaagcccccgt	8	7	12	14	1	0	2	0	1	0	1	0	2	0	2	4	1	4	5	4	1	3	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr7:98638089A>G	uc003upu.1	-	14	1860	c.1540T>C	c.(1540-1542)TTC>CTC	p.F514L	SMURF1_uc003upv.1_Missense_Mutation_p.F488L|SMURF1_uc003upt.2_Missense_Mutation_p.F488L	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	514	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			TGCTTGTAGAAGGGCACTGTG	0.542											OREG0018189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	66	55					0	0	0	0	G	98638089	G	G	98638089	3	3	271	1	0	0	0	0	1	0	0	0	14883	72	3	5	757	5	SMURF1	7	98638089	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	34471325	98638089	60500574	49	49182											
SMURF1	57154	broad.mit.edu	37	chr7	98645385	98645385	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcgacagttcgtgtctgagGactttcagcttctggactag	8	12	12	9	2	3	1	1	1	2	0	4	4	3	3	0	2	2	2	0	2	1	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr7:98645385G>A	uc003upu.1	-	11	1472	c.1152C>T	c.(1150-1152)GTC>GTT	p.V384V	SMURF1_uc003upv.1_Silent_p.V358V|SMURF1_uc003upt.2_Silent_p.V358V	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	384					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			CGTGTCTGAGGACTTTCAGCT	0.567													123	97					0	0	0	0	A	98645385	A	A	98645385	2	1	271	1	0	0	0	0	0	0	0	1	14883	1161	41	2		2	SMURF1	7	98645385	Silent	SNP	G	TCGA-CX-7082-01A-11D-2012-08	7296	98645385	60493278	50	49183											
SLC4A2	6522	broad.mit.edu	37	chr7	150771897	150771897	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccgccatcctggtcttcAttctcatcttcatggagaca	7	13	7	14	1	5	1	3	0	3	1	7	2	6	1	3	2	1	0	3	2	0	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr7:150771897A>G	uc003wit.3	+	19	3272	c.3016A>G	c.(3016-3018)ATT>GTT	p.I1006V	SLC4A2_uc011kve.1_Missense_Mutation_p.I997V|SLC4A2_uc003wiu.3_Missense_Mutation_p.I992V|SLC4A2_uc003wiv.3_Missense_Mutation_p.I200V|uc011kvf.1_3'UTR	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	1006	Membrane (anion exchange).|Helical; (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTGGTCTTCATTCTCATCTT	0.597													10	15					0	0	0	0	G	150771897	G	G	150771897	3	3	271	1	0	0	0	0	1	0	0	0	14718	217	8	5	3086	5	SLC4A2	7	150771897	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	52126512	150771897	8366766	51	49184											
MLL3	58508	broad.mit.edu	37	chr7	151945031	151945031	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaaattttctcttagtaaTagctggtttacccatgccaa	13	14	6	8	0	1	1	0	0	1	1	2	1	1	1	2	1	3	3	2	1	7	7			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr7:151945031T>C	uc003wla.2	-	14	2707	c.2488A>G	c.(2488-2490)ATT>GTT	p.I830V		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	830					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTCTTAGTAATAGCTGGTTTA	0.383			N		medulloblastoma								8	167					0	0	0	0	C	151945031	C	C	151945031	3	2	271	1	0	0	0	0	1	0	0	0	9675	1406	49	5	12431	5	MLL3	7	151945031	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	1173134	151945031	7193632	52	49185											
CCNE2	9134	broad.mit.edu	37	chr8	95897779	95897779	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actcttggagtttaggagcaTagatttcctttaaattgtaa	12	16	8	5	0	1	1	0	0	1	1	2	3	2	3	1	2	1	3	1	2	5	9			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr8:95897779T>C	uc003yhc.2	-	8	717	c.608A>G	c.(607-609)TAT>TGT	p.Y203C	CCNE2_uc003yhd.2_Missense_Mutation_p.Y203C	NM_057749	NP_477097	O96020	CCNE2_HUMAN	cyclin E2	203					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding				0	Breast(36;8.75e-07)					TTTAGGAGCATAGATTTCCTT	0.229													26	31					0	0	0	0	C	95897779	C	C	95897779	3	2	271	1	0	0	0	0	1	0	0	0	2936	1406	49	5	626	5	CCNE2	8	95897779	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08		95897779	50466243	53	49186											
TRHR	7201	broad.mit.edu	37	chr8	110100298	110100298	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggctacaagatctccaggaAttactactcacctatttacc	12	12	5	12	0	2	1	1	0	1	1	3	2	2	2	3	2	4	1	3	2	7	6			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr8:110100298A>T	uc003ymz.3	+	1	573	c.557A>T	c.(556-558)AAT>ATT	p.N186I		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	186	Extracellular (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			ATCTCCAGGAATTACTACTCA	0.403													14	51					0	0	0	0	T	110100298	T	T	110100298	3	4	271	1	0	0	0	0	1	0	0	0	16547	101	4	5	559	5	TRHR	8	110100298	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	14202519	110100298	36263724	54	49187											
TAF2	6873	broad.mit.edu	37	chr8	120809913	120809913	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gataccaacctaaaaatgctCatggaagcataagcagccac	17	6	7	11	0	1	0	1	0	0	0	1	2	1	1	3	1	6	3	3	1	7	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr8:120809913C>G	uc003you.2	-	7	1236	c.966G>C	c.(964-966)ATG>ATC	p.M322I		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	322					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TAAAAATGCTCATGGAAGCAT	0.338													11	25					0	0	0	0	G	120809913	G	G	120809913	3	3	271	1	0	0	0	0	1	0	0	0	15590	826	29	2	2713	2	TAF2	8	120809913	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	10709615	120809913	25554109	55	49188											
IL11RA	3590	broad.mit.edu	37	chr9	34655639	34655639	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcaggtccgtgaagctGtgttgtcctggagtgactgc	6	10	15	10	1	0	2	0	2	0	0	2	3	2	3	3	3	2	3	3	3	1	1			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr9:34655639G>A	uc003zvi.2	+	3	1494	c.138G>A	c.(136-138)CTG>CTA	p.L46L	IL11RA_uc011loq.1_Silent_p.L46L|IL11RA_uc003zvj.2_Silent_p.L46L|IL11RA_uc003zvk.2_Silent_p.L46L|IL11RA_uc010mke.2_Translation_Start_Site|IL11RA_uc003zvl.2_RNA	NM_004512	NP_004503	Q14626	I11RA_HUMAN	interleukin 11 receptor, alpha isoform 1	46	Ig-like C2-type.|Extracellular (Potential).					integral to plasma membrane	cytokine receptor activity			skin(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.174)	Oprelvekin(DB00038)	CCGTGAAGCTGTGTTGTCCTG	0.582													10	12					0	0	0	0	A	34655639	A	A	34655639	2	1	271	1	0	0	0	0	0	0	0	1	7662	1364	48	4		4	IL11RA	9	34655639	Silent	SNP	G	TCGA-CX-7082-01A-11D-2012-08		34655639	106557792	56	49189											
COL15A1	1306	broad.mit.edu	37	chr9	101817638	101817638	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgggcctccaggcctgcccgGaaatccaggcccggctgtga	6	6	14	15	2	0	1	0	1	0	0	2	2	2	2	6	5	1	1	6	5	1	0			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr9:101817638G>A	uc004azb.1	+	34	3382	c.3176G>A	c.(3175-3177)GGA>GAA	p.G1059E		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	1059	Triple-helical region 8 (COL8).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				GGCCTGCCCGGAAATCCAGGC	0.542													27	63					0	0	0	0	A	101817638	A	A	101817638	3	1	271	1	0	0	0	0	1	0	0	0	3687	1174	41	2	3310	2	COL15A1	9	101817638	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	67161999	101817638	39395793	57	49190											
OR1L4	254973	broad.mit.edu	37	chr9	125486501	125486501	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatctgcttcacaacagtcaTagtgcctaagatgctggtga	11	12	9	9	0	3	2	2	1	1	1	3	2	3	2	1	1	4	2	1	1	4	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr9:125486501T>C	uc004bmu.1	+	1	233	c.233T>C	c.(232-234)ATA>ACA	p.I78T		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	78	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACAACAGTCATAGTGCCTAAG	0.443													34	100					0	0	0	0	C	125486501	C	C	125486501	3	2	271	1	0	0	0	0	1	0	0	0	11019	1406	49	5	235	5	OR1L4	9	125486501	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	23668863	125486501	15726930	58	49191											
SURF2	6835	broad.mit.edu	37	chr9	136227265	136227266	+	Frame_Shift_Del	DEL	GA	-	-																															aaggccactgatgagagcagGagagagacgaccgtgtaccg																										TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr9:136227265_136227266delGA	uc004cdi.2	+	5	690_691	c.642_643delGA	c.(640-645)AGGAGAfs	p.R214fs		NM_017503	NP_059973	Q15527	SURF2_HUMAN	surfeit 2	214_215							protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		ATGAGAGCAGGAGAGAGACGAC	0.554													---	---	---								-	136227266	-	-	136227265	7	5	271	1	0	1	0	1	0	0	0	0	15470	1165	41	0	660	0	SURF2	9	136227265	Frame_Shift_Del	DEL	GA	TCGA-CX-7082-01A-11D-2012-08	10740764	136227265	4986166	59	49192											
SLC2A6	11182	broad.mit.edu	37	chr9	136338606	136338607	+	Nonsense_Mutation	DNP	GC	AT	AT																															agcgggtgctgccaggggctGcgccaagtccccccaggact																										TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr9:136338606_136338607GC>AT	uc004cee.2	-	8	1247_1248	c.1152_1153GC>AT	c.(1150-1155)GCGCAG>GCATAG	p.Q385*	SLC2A6_uc004cef.2_Intron|SLC2A6_uc004ceg.2_Nonsense_Mutation_p.Q362*	NM_017585	NP_060055	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose	385	Extracellular (Potential).					integral to membrane|plasma membrane	D-glucose transmembrane transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		GCCAGGGGCTGCGCCAAGTCCC	0.663													8	20					0	0	0	0	AT	136338607	AT	AT	136338606	4	1	271	1	0	0	0	0	0	1	0	0	14613	1328	46	4	382	4	SLC2A6	9	136338606	Nonsense_Mutation	DNP	GC	TCGA-CX-7082-01A-11D-2012-08	111341	136338606	4874825	60	49193											
GTPBP4	23560	broad.mit.edu	37	chr10	1038576	1038576	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgatagactttcacaaattCtaacagatttccccaaattg	15	13	4	9	0	2	3	1	1	1	2	3	3	3	3	2	0	1	0	2	0	4	6			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr10:1038576C>G	uc001ift.2	+	2	267	c.196C>G	c.(196-198)CTA>GTA	p.L66V	GTPBP4_uc010qac.1_5'UTR|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_5'UTR|GTPBP4_uc010qae.1_Missense_Mutation_p.L19V	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	66					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		TTCACAAATTCTAACAGATTT	0.343													15	24					0	0	0	0	G	1038576	G	G	1038576	3	3	271	1	0	0	0	0	1	0	0	0	6921	912	32	2	202	2	GTPBP4	10	1038576	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08		1038576	134496171	61	49194											
PRKG1	5592	broad.mit.edu	37	chr10	54040637	54040637	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attccaaaggaatcatttacAgggacctcaagccagaaaat	17	8	7	9	0	2	1	2	0	0	1	3	3	3	3	3	2	2	0	3	2	6	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr10:54040637A>G	uc001jjm.2	+	13	1641	c.1447A>G	c.(1447-1449)AGG>GGG	p.R483G	PRKG1_uc001jjo.2_Missense_Mutation_p.R498G|PRKG1_uc009xow.1_Missense_Mutation_p.R201G|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	483	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		AATCATTTACAGGGACCTCAA	0.423													3	82					0	0	0	0	G	54040637	G	G	54040637	3	3	271	1	0	0	0	0	1	0	0	0	12584	179	7	5	1812	5	PRKG1	10	54040637	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	53002061	54040637	81494110	62	49195											
SGPL1	8879	broad.mit.edu	37	chr10	72610941	72610941	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaatgttttaagctcaccAggaagatgcccattattggt	13	12	9	7	0	1	2	1	0	0	2	1	3	1	3	2	2	2	2	2	2	4	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr10:72610941A>T	uc001jrm.2	+	4	457	c.235A>T	c.(235-237)AGG>TGG	p.R79W		NM_003901	NP_003892	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	79	Cytoplasmic (Potential).				apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity				0					Pyridoxal Phosphate(DB00114)	TAAGCTCACCAGGAAGATGCC	0.328													28	45					0	0	0	0	T	72610941	T	T	72610941	3	4	271	1	0	0	0	0	1	0	0	0	14283	179	7	5	245	5	SGPL1	10	72610941	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	18570304	72610941	62923806	63	49196											
SMC3	9126	broad.mit.edu	37	chr10	112363045	112363045	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatggtgtaaagttcagaaaTaaggtaattttattttacat	15	17	7	2	0	1	1	1	0	0	1	1	1	1	1	0	2	1	3	0	2	8	9			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr10:112363045T>A	uc001kze.2	+	28	3705	c.3579T>A	c.(3577-3579)AAT>AAA	p.N1193K		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	1193					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		AGTTCAGAAATAAGGTAATTT	0.279													10	18					0	0	0	0	A	112363045	A	A	112363045	3	1	271	1	0	0	0	0	1	0	0	0	14848	1403	49	5	3689	5	SMC3	10	112363045	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	39752104	112363045	23171702	64	49197											
HMX3	340784	broad.mit.edu	37	chr10	124895904	124895904	+	Frame_Shift_Del	DEL	C	-	-																															cgcgcactacctggagcgctCcccagcctggtggtacccct																										TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr10:124895904delC	uc010quc.1	+	1	338	c.338delC	c.(337-339)TCCfs	p.S113fs		NM_001105574	NP_001099044	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	113					cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		CTGGAGCGCTCCCCAGCCTGG	0.672													---	---	---								-	124895904	-	-	124895904	7	5	271	1	0	1	0	1	0	0	0	0	7287	855	30	0	340	0	HMX3	10	124895904	Frame_Shift_Del	DEL	C	TCGA-CX-7082-01A-11D-2012-08	12532859	124895904	10638843	65	49198											
OR10Q1	219960	broad.mit.edu	37	chr11	57995517	57995517	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgtagaccaacgcgatttgGctgtcctcatcctctgaggt	7	12	11	11	2	2	2	1	1	1	1	4	3	4	2	3	2	1	2	3	2	2	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr11:57995517G>A	uc010rkd.1	-	1	831	c.831C>T	c.(829-831)AGC>AGT	p.S277S		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				ACGCGATTTGGCTGTCCTCAT	0.557													28	60					0	0	0	0	A	57995517	A	A	57995517	2	1	271	1	0	0	0	0	0	0	0	1	10970	1194	42	4		4	OR10Q1	11	57995517	Silent	SNP	G	TCGA-CX-7082-01A-11D-2012-08		57995517	77010999	66	49199											
RSF1	51773	broad.mit.edu	37	chr11	77411780	77411780	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttaccttgcttactttagAatttgtatctttctctgatt	7	23	4	7	0	2	2	0	1	2	1	3	2	2	2	1	0	3	2	1	0	5	10			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr11:77411780A>C	uc001oyn.2	-	6	2614	c.2494T>G	c.(2494-2496)TCT>GCT	p.S832A	RSF1_uc001oym.2_Missense_Mutation_p.S580A	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	832					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			CTTACTTTAGAATTTGTATCT	0.284													24	16					0	0	0	0	C	77411780	C	C	77411780	3	2	271	1	0	0	0	0	1	0	0	0	13764	246	9	5	1875	5	RSF1	11	77411780	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	19416263	77411780	57594736	67	49200											
MAML2	84441	broad.mit.edu	37	chr11	95825060	95825060	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagtagagcccttacctgtCtctgttgttgggagacttgg	6	14	13	8	0	1	2	0	0	1	2	2	3	1	2	2	2	2	4	2	2	3	6			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr11:95825060C>G	uc001pfw.1	-	2	3420	c.2135G>C	c.(2134-2136)AGA>ACA	p.R712T		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	712					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CCTTACCTGTCTCTGTTGTTG	0.443			T	MECT1|CRTC3	salivary gland mucoepidermoid								9	6					0	0	0	0	G	95825060	G	G	95825060	3	3	271	1	0	0	0	0	1	0	0	0	9259	913	32	2	1351	2	MAML2	11	95825060	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	18413280	95825060	39181456	68	49201											
PDGFD	80310	broad.mit.edu	37	chr11	103780424	103780424	+	Nonstop_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaggatgtgcacattctcttAtcgaggtggtcttgagctgc	8	13	12	8	1	2	1	0	1	2	0	4	3	2	2	0	3	3	2	0	3	2	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr11:103780424A>T	uc001phq.2	-	7	1483	c.1111T>A	c.(1111-1113)TAA>AAA	p.*371K	PDGFD_uc001php.2_Nonstop_Mutation_p.*365K	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	371					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		ACATTCTCTTATCGAGGTGGT	0.443													10	68					0	0	0	0	T	103780424	T	T	103780424	4	4	271	1	0	0	0	0	0	0	0	0	11714	462	16	5	5	5	PDGFD	11	103780424	Nonstop_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	7955364	103780424	31226092	69	49202											
VSIG2	23584	broad.mit.edu	37	chr11	124618415	124618415	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	caatcagagctccggccactCggccttgggagggttctaag	8	8	13	12	2	2	1	1	0	1	1	4	2	3	2	3	4	1	2	3	4	2	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr11:124618415C>G	uc001qas.2	-	6	798	c.722G>C	c.(721-723)CGA>CCA	p.R241P	VSIG2_uc001qat.2_Missense_Mutation_p.R241P	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	241	Extracellular (Potential).					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		TCCGGCCACTCGGCCTTGGGA	0.607													25	13					0	0	0	0	G	124618415	G	G	124618415	3	3	271	1	0	0	0	0	1	0	0	0	17292	884	31	3	269	3	VSIG2	11	124618415	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	20837991	124618415	10388101	70	49203											
STT3A	3703	broad.mit.edu	37	chr11	125479465	125479465	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tactattttgacctgcagctCctcgtcttcatgtttccagg	6	16	7	12	1	2	1	1	1	1	0	5	1	4	1	3	1	3	3	3	1	2	6			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr11:125479465C>T	uc001qcd.2	+	10	1208	c.1098C>T	c.(1096-1098)CTC>CTT	p.L366L	STT3A_uc009zbm.2_Silent_p.L366L|STT3A_uc001qce.2_Silent_p.L366L|STT3A_uc010sbg.1_Silent_p.L274L|STT3A_uc009zbn.2_Intron	NM_152713	NP_689926	P46977	STT3A_HUMAN	integral membrane protein 1	366	Helical; (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		ACCTGCAGCTCCTCGTCTTCA	0.453													37	31					0	0	0	0	T	125479465	T	T	125479465	2	4	271	1	0	0	0	0	0	0	0	1	15399	842	30	2		2	STT3A	11	125479465	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08	861050	125479465	9527051	71	49204											
PZP	5858	broad.mit.edu	37	chr12	9307319	9307319	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggctggctgggccgtgaGataagcgaggagcacatagg	9	5	20	7	2	0	1	0	1	0	1	0	4	0	2	1	6	2	3	1	6	2	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr12:9307319G>T	uc001qvl.2	-	29	3696	c.3667C>A	c.(3667-3669)CTC>ATC	p.L1223I	PZP_uc009zgl.2_Missense_Mutation_p.L1009I	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TGGGCCGTGAGATAAGCGAGG	0.582													20	26					3.62473e-10	1.27015e-09	1	0	T	9307319	T	T	9307319	3	4	271	1	0	0	0	0	1	0	0	0	12934	942	33	2	813	2	PZP	12	9307319	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08		9307319	124544576	72	49205											
PRB1	5542	broad.mit.edu	37	chr12	11506549	11506549	+	Frame_Shift_Del	DEL	G	-	-																															ggggttggttacctccttgtGggggtggtccttgtggcttt																										TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr12:11506549delG	uc001qzw.1	-	4	525	c.488delC	c.(487-489)CCAfs	p.P163fs	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	224	9.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			ACCTCCTTGTGGGGGTGGTCC	0.612													---	---	---								-	11506549	-	-	11506549	7	5	271	1	0	1	0	1	0	0	0	0	12504	1348	47	0	511	0	PRB1	12	11506549	Frame_Shift_Del	DEL	G	TCGA-CX-7082-01A-11D-2012-08	2199230	11506549	122345346	73	49206											
KRT86	3892	broad.mit.edu	37	chr12	52699946	52699946	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctggagggtgccctgcagAaggccaagcaggacatggcc	10	4	16	11	0	0	1	0	0	0	1	0	3	0	3	3	5	4	3	3	5	2	0			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr12:52699946A>G	uc010snq.1	+	8	1262	c.1129A>G	c.(1129-1131)AAG>GAG	p.K377E	KRT86_uc009zmg.2_Missense_Mutation_p.K377E|KRT81_uc001sac.2_Intron|KRT86_uc001sad.2_Missense_Mutation_p.K377E	NM_002284	NP_002275	O43790	KRT86_HUMAN	keratin 86	377	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGCCCTGCAGAAGGCCAAGCA	0.642											OREG0021845	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	76					0	0	0	0	G	52699946	G	G	52699946	3	3	271	1	0	0	0	0	1	0	0	0	8539	247	9	5	1155	5	KRT86	12	52699946	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	41193397	52699946	81151949	74	49207											
TMEM194A	23306	broad.mit.edu	37	chr12	57457026	57457026	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgaaacacaggcccatcaGctgcaaggtccaggtcagca	13	5	10	13	0	2	1	2	1	0	0	3	1	3	1	2	3	4	3	2	3	2	0	rs148717635	byFrequency	TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr12:57457026G>A	uc001smy.2	-	7	902	c.856C>T	c.(856-858)CTG>TTG	p.L286L	TMEM194A_uc001smx.2_Silent_p.L213L|TMEM194A_uc010sra.1_Silent_p.L27L	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	286						integral to membrane					0						AGGCCCATCAGCTGCAAGGTC	0.443													52	81					0	0	0	0	A	57457026	A	A	57457026	2	1	271	1	0	0	0	0	0	0	0	1	16182	962	34	4		4	TMEM194A	12	57457026	Silent	SNP	G	TCGA-CX-7082-01A-11D-2012-08	4757080	57457026	76394869	75	49208											
AGAP2	116986	broad.mit.edu	37	chr12	58124681	58124681	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggggccgcttgcccgggactTtgactgttgttcgcagcaag	5	10	15	11	3	0	1	0	1	0	0	1	2	0	2	2	3	2	5	2	3	1	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr12:58124681T>G	uc001spq.2	-	11	2201	c.2201A>C	c.(2200-2202)AAA>ACA	p.K734T	AGAP2_uc001spp.2_Missense_Mutation_p.K734T|AGAP2_uc001spr.2_Missense_Mutation_p.K398T	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	734	PH.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						GCCCGGGACTTTGACTGTTGT	0.592													3	7					0	0	0	0	G	58124681	G	G	58124681	3	3	271	1	0	0	0	0	1	0	0	0	368	1841	64	5	1413	5	AGAP2	12	58124681	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	667655	58124681	75727214	76	49209											
XPOT	11260	broad.mit.edu	37	chr12	64828639	64828639	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acattgtccccgcatgtttcCtagcacctttaaaacaaacc	12	11	4	14	1	0	0	0	0	0	0	2	0	2	0	5	0	3	3	5	0	4	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr12:64828639C>G	uc001ssb.2	+	21	3061	c.2635C>G	c.(2635-2637)CTA>GTA	p.L879V		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	879	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		CGCATGTTTCCTAGCACCTTT	0.378													36	59					0	0	0	0	G	64828639	G	G	64828639	3	3	271	1	0	0	0	0	1	0	0	0	17518	680	24	4	2713	4	XPOT	12	64828639	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	6703958	64828639	69023256	77	49210											
GRIP1	23426	broad.mit.edu	37	chr12	66932903	66932903	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcaagaaccactctttctcCcacattcttcagcaagctga	11	12	4	14	0	5	2	2	1	3	1	6	2	5	2	2	0	3	2	2	0	3	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr12:66932903C>A	uc001stk.2	-	4	614	c.373G>T	c.(373-375)GGA>TGA	p.G125*	GRIP1_uc010sta.1_Nonsense_Mutation_p.G69*|GRIP1_uc001stl.1_Nonsense_Mutation_p.G69*|GRIP1_uc001stm.2_Nonsense_Mutation_p.G125*	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	125	PDZ 1.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		ACTCTTTCTCCCACATTCTTC	0.363													41	89					6.48837e-15	2.39223e-14	1	0	A	66932903	A	A	66932903	4	1	271	1	0	0	0	0	0	1	0	0	6826	632	22	4	2941	4	GRIP1	12	66932903	Nonsense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	2104264	66932903	66918992	78	49211											
PTPRB	5787	broad.mit.edu	37	chr12	70983891	70983891	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgatgttgagcagcaccaCagaatcattgaagagtagga	15	8	12	6	0	1	5	1	3	0	2	1	6	1	6	1	1	2	4	1	1	3	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr12:70983891C>A	uc001swb.3	-	6	1279	c.1249G>T	c.(1249-1251)GTG>TTG	p.V417L	PTPRB_uc010sto.1_Missense_Mutation_p.V417L|PTPRB_uc010stp.1_Intron|PTPRB_uc001swc.3_Missense_Mutation_p.V635L|PTPRB_uc001swa.3_Missense_Mutation_p.V635L|PTPRB_uc001swd.3_Missense_Mutation_p.V634L|PTPRB_uc009zrr.1_Missense_Mutation_p.V514L	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	417	Fibronectin type-III 5.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGCAGCACCACAGAATCATTG	0.512											OREG0021990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	78					2.43468e-25	9.13544e-25	1	0	A	70983891	A	A	70983891	3	1	271	1	0	0	0	0	1	0	0	0	12861	478	17	4	4852	4	PTPRB	12	70983891	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	4050988	70983891	62868004	79	49212											
DNAH10	196385	broad.mit.edu	37	chr12	124270320	124270320	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcacgggtctggcttccacGtggtcctggacaccatcccc	5	8	11	17	3	1	0	0	0	1	0	4	1	4	1	5	4	0	2	5	4	0	1			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr12:124270320G>A	uc001uft.3	+	9	1100	c.1075G>A	c.(1075-1077)GTG>ATG	p.V359M		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	359	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGGCTTCCACGTGGTCCTGGA	0.537													23	46					0	0	0	0	A	124270320	A	A	124270320	3	1	271	1	0	0	0	0	1	0	0	0	4620	1145	40	1	1109	1	DNAH10	12	124270320	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	53286429	124270320	9581575	80	49213											
MPHOSPH8	54737	broad.mit.edu	37	chr13	20221396	20221396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccggaggttgagcggggaaGagagaggcctctggtccacg	8	5	19	9	3	1	3	0	1	1	2	2	6	2	5	3	6	1	1	3	6	1	1			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr13:20221396G>A	uc001umh.2	+	3	1192	c.1183G>A	c.(1183-1185)GAG>AAG	p.E395K	MPHOSPH8_uc001umf.1_Missense_Mutation_p.E395K|MPHOSPH8_uc001umg.2_Missense_Mutation_p.E395K|MPHOSPH8_uc001umi.2_Missense_Mutation_p.E92K	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	395					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		GAGCGGGGAAGAGAGAGGCCT	0.542													5	48					0	0	0	0	A	20221396	A	A	20221396	3	1	271	1	0	0	0	0	1	0	0	0	9780	943	33	2	1193	2	MPHOSPH8	13	20221396	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08		20221396	94948482	81	49214											
OLFM4	10562	broad.mit.edu	37	chr13	53624472	53624472	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgactcaaactctccctaatGctgcctataataaccgcttt	11	13	4	13	1	2	1	1	1	1	0	3	1	2	1	3	0	4	2	3	0	5	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr13:53624472G>A	uc001vhl.2	+	5	1099	c.1099G>A	c.(1099-1101)GCT>ACT	p.A367T	OLFM4_uc001vhk.1_3'UTR	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	367	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		TCTCCCTAATGCTGCCTATAA	0.408													32	46					0	0	0	0	A	53624472	A	A	53624472	3	1	271	1	0	0	0	0	1	0	0	0	10909	1319	46	4	1117	4	OLFM4	13	53624472	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	33403076	53624472	61545406	82	49215											
JUB	84962	broad.mit.edu	37	chr14	23447583	23447583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaaacaaagcactgggtgtGgtagaggctgtccagggcct	10	7	15	9	0	0	1	0	0	0	1	1	1	1	1	2	4	2	4	2	4	3	1			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr14:23447583G>A	uc001whz.2	-	2	1454	c.1078C>T	c.(1078-1080)CAC>TAC	p.H360Y	JUB_uc001why.2_5'Flank	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	360	LIM zinc-binding 1.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CACTGGGTGTGGTAGAGGCTG	0.527													77	24					0	0	0	0	A	23447583	A	A	23447583	3	1	271	1	0	0	0	0	1	0	0	0	8007	1348	47	4	566	4	JUB	14	23447583	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08		23447583	83901957	83	49216											
MDGA2	161357	broad.mit.edu	37	chr14	47351355	47351355	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagctctgtcaagttatatgTaattaattctcccttttgaa	11	18	5	7	0	3	1	1	1	2	0	4	1	3	1	1	0	1	3	1	0	7	8			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr14:47351355T>A	uc001wwj.3	-	11	2297	c.2101A>T	c.(2101-2103)ACA>TCA	p.T701S	MDGA2_uc001wwh.3_5'UTR|MDGA2_uc001wwi.3_Missense_Mutation_p.T472S|MDGA2_uc010ani.2_Missense_Mutation_p.T261S	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	701					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						AAGTTATATGTAATTAATTCT	0.373													18	17					0	0	0	0	A	47351355	A	A	47351355	3	1	271	1	0	0	0	0	1	0	0	0	9460	1638	57	5	797	5	MDGA2	14	47351355	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	23903772	47351355	59998185	84	49217											
EIF2AK4	440275	broad.mit.edu	37	chr15	40295429	40295429	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactccactactgcttcccCgaaacagacaaatatatgag	14	9	6	12	1	0	2	0	1	0	1	2	3	2	2	3	0	4	2	3	0	6	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr15:40295429C>T	uc001zkm.1	+	23	3321	c.3271C>T	c.(3271-3273)CGA>TGA	p.R1091*	EIF2AK4_uc010bbj.1_Nonsense_Mutation_p.R792*|EIF2AK4_uc001zkn.1_Nonsense_Mutation_p.R191*|EIF2AK4_uc001zko.1_Nonsense_Mutation_p.R29*	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	1091	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		ACTGCTTCCCCGAAACAGACA	0.473													19	41					0	0	0	0	T	40295429	T	T	40295429	4	4	271	1	0	0	0	0	0	1	0	0	5021	644	23	1	3361	1	EIF2AK4	15	40295429	Nonsense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08		40295429	62235963	85	49218											
CENPT	80152	broad.mit.edu	37	chr16	67865170	67865170	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgcaaaaaggcacccacgtCtacagctcggcgggctggag	10	4	13	14	4	1	0	0	0	1	0	2	1	1	1	2	4	2	4	2	4	3	1			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr16:67865170C>T	uc002eun.3	-	10	1201	c.652G>A	c.(652-654)GAC>AAC	p.D218N	CENPT_uc002eum.3_Missense_Mutation_p.D218N|CENPT_uc010vkc.1_5'UTR|CENPT_uc010vkd.1_5'UTR|CENPT_uc010vke.1_Missense_Mutation_p.D115N	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	218					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		GCACCCACGTCTACAGCTCGG	0.607													37	31					0	0	0	0	T	67865170	T	T	67865170	3	4	271	1	0	0	0	0	1	0	0	0	3257	913	32	2	1061	2	CENPT	16	67865170	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08		67865170	22489583	86	49219											
CBFA2T3	863	broad.mit.edu	37	chr16	88951552	88951552	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcctccaggcggtagtgcGgcggcggtgtgggctgcggt	2	9	20	10	5	0	0	0	0	0	0	2	0	2	0	2	7	2	2	2	7	1	1	rs151180006		TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr16:88951552G>A	uc002fmm.1	-	7	1205	c.1019C>T	c.(1018-1020)CCG>CTG	p.P340L	CBFA2T3_uc002fml.1_Missense_Mutation_p.P254L|CBFA2T3_uc010cif.1_Missense_Mutation_p.P279L|CBFA2T3_uc002fmn.1_Missense_Mutation_p.P315L	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	340	Mediates localization to the nucleus (By similarity).|Mediates interaction with PDE7A (in isoform 2).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		GCGGTAGTGCGGCGGCGGTGT	0.697			T	RUNX1	AML								7	19					0	0	0	0	A	88951552	A	A	88951552	3	1	271	1	0	0	0	0	1	0	0	0	2710	1116	39	1	966	1	CBFA2T3	16	88951552	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	21086382	88951552	1403201	87	49220											
ABR	29	broad.mit.edu	37	chr17	1028581	1028581	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccccgccctggctgcgggcGctgagctgcggggacatggt	3	6	17	15	4	0	1	0	1	0	0	0	2	0	2	3	5	3	3	3	5	0	0			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr17:1028581G>A	uc002fsd.2	-	2	293	c.183C>T	c.(181-183)AGC>AGT	p.S61S	ABR_uc002fse.2_Silent_p.S15S|ABR_uc010cjq.1_Silent_p.S73S	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	61					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		GGCTGCGGGCGCTGAGCTGCG	0.662													33	70					0	0	0	0	A	1028581	A	A	1028581	2	1	271	1	0	0	0	0	0	0	0	1	99	1078	38	1		1	ABR	17	1028581	Silent	SNP	G	TCGA-CX-7082-01A-11D-2012-08		1028581	80166629	88	49221											
TP53	7157	broad.mit.edu	37	chr17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcaccaccacactatgtcGaaaagtgtttctgtcatcca	11	10	8	12	1	2	0	1	0	1	0	4	1	3	0	3	1	0	2	3	1	3	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	13					0	0	0	0	A	7578212	A	A	7578212	4	1	271	1	0	0	0	0	0	1	0	0	16448	1066	37	1	657	1	TP53	17	7578212	Nonsense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	6549631	7578212	73616998	89	49222											
SLC47A2	146802	broad.mit.edu	37	chr17	19583338	19583338	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgctgctgctgccggccTgaatgtttcttagcctaaag	6	13	10	12	1	2	1	0	1	2	0	2	1	2	1	3	1	5	4	3	1	4	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr17:19583338T>G	uc002gwe.3	-	16	1690	c.1515A>C	c.(1513-1515)TCA>TCC	p.S505S	SLC47A2_uc002gwg.3_Silent_p.S469S|SLC47A2_uc002gwf.3_Silent_p.S483S|SLC47A2_uc002gwh.3_RNA|SLC47A2_uc002gwi.2_RNA|SLC47A2_uc010cqs.1_RNA	NM_152908	NP_690872	Q86VL8	S47A2_HUMAN	solute carrier family 47, member 2 isoform 1	505	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					GCTGCCGGCCTGAATGTTTCT	0.498													14	24					0	0	0	0	G	19583338	G	G	19583338	2	3	271	1	0	0	0	0	0	0	0	1	14712	1567	55	5		5	SLC47A2	17	19583338	Silent	SNP	T	TCGA-CX-7082-01A-11D-2012-08	12005126	19583338	61611872	90	49223											
NXPH3	11248	broad.mit.edu	37	chr17	47656378	47656378	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaagctgtagagttccacCaggaacagcagatcttcatc	13	9	9	10	0	2	2	1	0	1	2	4	3	3	3	2	1	3	5	2	1	4	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr17:47656378C>T	uc002ipa.2	+	2	759	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	NXPH3_uc010wlw.1_Nonsense_Mutation_p.Q159*	NM_007225	NP_009156	O95157	NXPH3_HUMAN	neurexophilin 3 precursor	159	IV (linker domain).				neuropeptide signaling pathway	extracellular region				pancreas(1)|skin(1)	2	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					AGAGTTCCACCAGGAACAGCA	0.567													5	77					0	0	0	0	T	47656378	T	T	47656378	4	4	271	1	0	0	0	0	0	1	0	0	10846	595	21	4	481	4	NXPH3	17	47656378	Nonsense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08	28073040	47656378	33538832	91	49224											
SS18	6760	broad.mit.edu	37	chr18	23632698	23632698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctctgtgatgatggcacaGaatggttgtaacctcccatg	9	12	11	9	0	1	3	0	2	1	1	2	3	2	3	2	2	2	4	2	2	2	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr18:23632698G>A	uc002kvm.2	-	5	575	c.497C>T	c.(496-498)TCT>TTT	p.S166F	SS18_uc002kvn.2_Missense_Mutation_p.S166F|SS18_uc010xbf.1_Missense_Mutation_p.S84F|SS18_uc010xbg.1_Missense_Mutation_p.S114F|SS18_uc010xbh.1_Missense_Mutation_p.S114F|SS18_uc010xbi.1_Missense_Mutation_p.S143F|SS18_uc010dlz.1_Missense_Mutation_p.S114F	NM_001007559	NP_001007560	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	166	Transcriptional activation.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					TGATGGCACAGAATGGTTGTA	0.458			T	SSX1| SSX2	synovial sarcoma								48	92					0	0	0	0	A	23632698	A	A	23632698	3	1	271	1	0	0	0	0	1	0	0	0	15241	942	33	2	787	2	SS18	18	23632698	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08		23632698	54444550	92	49225											
RTTN	25914	broad.mit.edu	37	chr18	67843922	67843922	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgccttaccttttcaacagGgagaagcgtttgtagcagtc	9	12	10	10	1	1	1	1	0	0	1	2	2	1	1	2	1	5	3	2	1	4	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr18:67843922G>A	uc002lkp.2	-	11	1533	c.1465C>T	c.(1465-1467)CCT>TCT	p.P489S	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_5'UTR|RTTN_uc002lkq.1_Missense_Mutation_p.P489S	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	489							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				TTTTCAACAGGGAGAAGCGTT	0.418													26	59					0	0	0	0	A	67843922	A	A	67843922	3	1	271	1	0	0	0	0	1	0	0	0	13802	1232	43	4	5371	4	RTTN	18	67843922	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	44211224	67843922	10233326	93	49226											
MUC16	94025	broad.mit.edu	37	chr19	9046408	9046408	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgatctgtgaagtcaccatCtctggtgcaccaggtgagat	9	11	12	9	0	3	3	1	3	2	1	4	4	3	3	2	2	1	1	2	2	1	0			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr19:9046408C>T	uc002mkp.2	-	5	35427	c.35223G>A	c.(35221-35223)GAG>GAA	p.E11741E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11743	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAGTCACCATCTCTGGTGCAC	0.493													44	52					0	0	0	0	T	9046408	T	T	9046408	2	4	271	1	0	0	0	0	0	0	0	1	10026	912	32	2		2	MUC16	19	9046408	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08		9046408	50082575	94	49227											
EPS15L1	58513	broad.mit.edu	37	chr19	16514739	16514739	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttgcgttttcagtgatgaGatctgaaatgagatgttaaa	13	15	10	3	1	2	4	1	4	1	2	2	6	2	4	0	0	1	2	0	0	3	4			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr19:16514739G>C	uc002ndz.1	-	15	1437	c.1431C>G	c.(1429-1431)ATC>ATG	p.I477M	EPS15L1_uc002ndx.2_Missense_Mutation_p.I477M|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.I367M|EPS15L1_uc010xpf.1_Missense_Mutation_p.I380M|EPS15L1_uc002nea.1_Missense_Mutation_p.I477M|EPS15L1_uc010eah.1_Missense_Mutation_p.I477M|EPS15L1_uc002neb.1_Missense_Mutation_p.I323M|EPS15L1_uc002nec.1_Missense_Mutation_p.I477M	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	477					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						TCAGTGATGAGATCTGAAATG	0.458													13	21					0	0	0	0	C	16514739	C	C	16514739	3	2	271	1	0	0	0	0	1	0	0	0	5217	932	33	2	1199	2	EPS15L1	19	16514739	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	7468331	16514739	42614244	95	49228											
ZNF737	100129842	broad.mit.edu	37	chr19	20728437	20728437	+	Frame_Shift_Del	DEL	T	-	-																															ccccagtatgaattttcttaTgtgtagtaagggttgaagac																										TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr19:20728437delT	uc002npa.2	-	4	752	c.572delA	c.(571-573)CATfs	p.H191fs		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	191					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AATTTTCTTATGTGTAGTAAG	0.358													---	---	---								-	20728437	-	-	20728437	7	5	271	1	0	1	0	1	0	0	0	0	18193	1464	51	0	1042	0	ZNF737	19	20728437	Frame_Shift_Del	DEL	T	TCGA-CX-7082-01A-11D-2012-08	4213698	20728437	38400546	96	49229											
UQCRFS1	7386	broad.mit.edu	37	chr19	29698472	29698472	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctcttaaccaacaatcaccaTatcgtcactggtgaactcat	13	11	4	13	1	4	1	3	1	1	0	5	1	4	1	2	1	3	0	2	1	5	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr19:29698472T>C	uc002nsd.2	-	2	919	c.808A>G	c.(808-810)ATG>GTG	p.M270V		NM_006003	NP_005994	P47985	UCRI_HUMAN	ubiquinol-cytochrome c reductase, Rieske	270	Rieske.				respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity				0	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)			ACAATCACCATATCGTCACTG	0.473													14	26					0	0	0	0	C	29698472	C	C	29698472	3	2	271	1	0	0	0	0	1	0	0	0	17089	1406	49	5	20	5	UQCRFS1	19	29698472	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	8970035	29698472	29430511	97	49230											
ZNF507	22847	broad.mit.edu	37	chr19	32844889	32844889	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacatcagcacagaaaatcAtcagcagcagccccaataaa	18	6	5	12	0	3	1	3	0	0	1	3	1	3	1	2	0	5	3	2	0	6	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr19:32844889A>G	uc002nte.2	+	3	1425	c.1153A>G	c.(1153-1155)ATC>GTC	p.I385V	ZNF507_uc002ntc.2_Missense_Mutation_p.I385V|ZNF507_uc010xrn.1_Missense_Mutation_p.I385V|ZNF507_uc002ntd.2_Missense_Mutation_p.I385V	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					ACAGAAAATCATCAGCAGCAG	0.458													29	44					0	0	0	0	G	32844889	G	G	32844889	3	3	271	1	0	0	0	0	1	0	0	0	18020	217	8	5	1155	5	ZNF507	19	32844889	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	3146417	32844889	26284094	98	49231											
ZNF345	25850	broad.mit.edu	37	chr19	37368870	37368870	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaatgtgggaaggcctttGgtagtggctcaaaacttatc	11	11	13	6	0	1	0	1	0	0	0	2	2	1	2	1	5	1	2	1	5	6	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr19:37368870G>A	uc002oex.2	+	3	1516	c.1138G>A	c.(1138-1140)GGT>AGT	p.G380S	ZNF345_uc002oey.3_Missense_Mutation_p.G380S|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	380	C2H2-type 12.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAAGGCCTTTGGTAGTGGCTC	0.418													14	50					0	0	0	0	A	37368870	A	A	37368870	3	1	271	1	0	0	0	0	1	0	0	0	17926	1348	47	4	1140	4	ZNF345	19	37368870	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	4523981	37368870	21760113	99	49232											
ZNF345	25850	broad.mit.edu	37	chr19	37368948	37368948	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtaaagaatgtggaaagTcctttagtagtggttcagct	13	13	11	4	0	1	1	1	0	0	1	2	2	2	2	1	2	1	4	1	2	7	5			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr19:37368948T>G	uc002oex.2	+	3	1594	c.1216T>G	c.(1216-1218)TCC>GCC	p.S406A	ZNF345_uc002oey.3_Missense_Mutation_p.S406A|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	406	C2H2-type 13.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATGTGGAAAGTCCTTTAGTAG	0.433													8	42					0	0	0	0	G	37368948	G	G	37368948	3	3	271	1	0	0	0	0	1	0	0	0	17926	1667	58	5	1218	5	ZNF345	19	37368948	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	78	37368948	21760035	100	49233											
ZNF225	7768	broad.mit.edu	37	chr19	44636171	44636171	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaagagctttggctgggcCtcgtgtcttttgaatcatca	7	13	13	8	1	3	2	2	1	1	1	4	3	3	3	1	3	1	2	1	3	2	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr19:44636171C>T	uc002oyj.1	+	5	1647	c.1404C>T	c.(1402-1404)GCC>GCT	p.A468A	ZNF225_uc010eje.1_Silent_p.A385A|ZNF225_uc010ejf.1_Silent_p.A468A	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	468	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TTGGCTGGGCCTCGTGTCTTT	0.418													27	34					0	0	0	0	T	44636171	T	T	44636171	2	4	271	1	0	0	0	0	0	0	0	1	17846	668	24	4		4	ZNF225	19	44636171	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08	7267223	44636171	14492812	101	49234											
ZNF233	353355	broad.mit.edu	37	chr19	44777755	44777755	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacataggagagaaatgctaTaggaatggtgacagtggtga	15	8	14	4	0	0	3	0	2	0	1	0	6	0	5	0	4	1	1	0	4	5	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr19:44777755T>C	uc002oyz.1	+	5	1069	c.942T>C	c.(940-942)TAT>TAC	p.Y314Y	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Silent_p.Y129Y	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	314	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				AGAAATGCTATAGGAATGGTG	0.488													22	29					0	0	0	0	C	44777755	C	C	44777755	2	2	271	1	0	0	0	0	0	0	0	1	17853	1413	49	5		5	ZNF233	19	44777755	Silent	SNP	T	TCGA-CX-7082-01A-11D-2012-08	141584	44777755	14351228	102	49235											
NAPB	63908	broad.mit.edu	37	chr20	23401954	23401954	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgctcacccaaacagccctCggaggaaggagtgggaggcc	10	3	15	13	2	1	0	1	0	0	0	2	4	1	4	3	5	2	1	3	5	2	0			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr20:23401954C>T	uc002wta.2	-	1	203	c.86G>A	c.(85-87)CGA>CAA	p.R29Q	NAPB_uc002wtc.2_5'UTR|NAPB_uc002wtb.2_Missense_Mutation_p.R29Q|NAPB_uc002wtd.3_RNA|NAPB_uc010zst.1_Missense_Mutation_p.R29Q	NM_022080	NP_071363	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment	29					intracellular protein transport|vesicle-mediated transport	membrane				ovary(1)	1	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)					AAACAGCCCTCGGAGGAAGGA	0.697													4	7					0	0	0	0	T	23401954	T	T	23401954	3	4	271	1	0	0	0	0	1	0	0	0	10215	884	31	1	854	1	NAPB	20	23401954	Missense_Mutation	SNP	C	TCGA-CX-7082-01A-11D-2012-08		23401954	39623566	103	49236											
KRTAP26-1	388818	broad.mit.edu	37	chr21	31692054	31692054	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caggaactggagaagaaagaAgcaggaagaaaactgcttcc	18	4	12	7	0	0	4	0	0	0	4	1	7	1	6	1	3	4	2	1	3	7	1			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr21:31692054A>G	uc002ynw.2	-	1	554	c.300T>C	c.(298-300)GCT>GCC	p.A100A		NM_203405	NP_981950	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	100						intermediate filament				ovary(1)	1						AGAAGAAAGAAGCAGGAAGAA	0.542													25	74					0	0	0	0	G	31692054	G	G	31692054	2	3	271	1	0	0	0	0	0	0	0	1	8583	59	3	5		5	KRTAP26-1	21	31692054	Silent	SNP	A	TCGA-CX-7082-01A-11D-2012-08		31692054	16437841	104	49237											
MORC2	22880	broad.mit.edu	37	chr22	31330915	31330915	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaggtcgggatgcagtcttGacgagagtgttggcaggctt	7	10	17	7	2	1	2	0	1	1	1	2	4	1	3	0	4	1	5	0	4	0	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr22:31330915G>C	uc003aje.1	-	20	3224	c.1860C>G	c.(1858-1860)GTC>GTG	p.V620V		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	682							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						ATGCAGTCTTGACGAGAGTGT	0.602													26	56					0	0	0	0	C	31330915	C	C	31330915	2	2	271	1	0	0	0	0	0	0	0	1	9755	1277	45	2		2	MORC2	22	31330915	Silent	SNP	G	TCGA-CX-7082-01A-11D-2012-08		31330915	19973651	105	49238											
MEI1	150365	broad.mit.edu	37	chr22	42191530	42191531	+	Frame_Shift_Ins	INS	-	T	T																															accacactccaggccctgcaINStggcttcttccagcaggtgg																										TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr22:42191530_42191531insT	uc003baz.1	+	29	3675_3676	c.3650_3651insT	c.(3649-3651)CATfs	p.H1217fs	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Frame_Shift_Ins_p.H603fs|MEI1_uc003bbc.1_Frame_Shift_Ins_p.H585fs|MEI1_uc010gym.1_Frame_Shift_Ins_p.H550fs|MEI1_uc003bbd.1_Intron|MEI1_uc010gyn.1_RNA|MEI1_uc003bbe.1_RNA|MEI1_uc003bbf.2_Frame_Shift_Ins_p.H231fs|MEI1_uc003bbg.2_Intron	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	1217							binding			central_nervous_system(1)|skin(1)	2						CAGGCCCTGCATGGCTTCTTCC	0.574													---	---	---								T	42191531	T	T	42191530	7	5	271	1	0	1	1	0	0	0	0	0	9518	217	8	0	3764	0	MEI1	22	42191530	Frame_Shift_Ins	INS	-	TCGA-CX-7082-01A-11D-2012-08	10860615	42191530	9113036	106	49239											
PLXNB2	23654	broad.mit.edu	37	chr22	50716358	50716358	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctgctcgtccaggaagtcgaAgaagtacttgactgcaggtg	10	9	13	9	2	0	2	0	1	0	1	3	4	1	3	1	2	3	3	1	2	4	2			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr22:50716358A>G	uc003bkv.3	-	32	5078	c.4972T>C	c.(4972-4974)TTC>CTC	p.F1658L	PLXNB2_uc003bkt.1_Missense_Mutation_p.F450L|PLXNB2_uc003bku.1_Missense_Mutation_p.F643L	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1658	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGGAAGTCGAAGAAGTACTTG	0.602													29	45					0	0	0	0	G	50716358	G	G	50716358	3	3	271	1	0	0	0	0	1	0	0	0	12179	72	3	5	568	5	PLXNB2	22	50716358	Missense_Mutation	SNP	A	TCGA-CX-7082-01A-11D-2012-08	8524828	50716358	588208	107	49240											
SHANK3	85358	broad.mit.edu	37	chr22	51117039	51117039	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgaagaagttcatggactaCgtccagctgcatagcacgga	12	8	11	10	2	1	2	1	1	0	1	2	4	2	4	1	2	4	4	1	2	4	3			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chr22:51117039C>T	uc003bne.1	+	4	366	c.366C>T	c.(364-366)TAC>TAT	p.Y122Y		NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	122										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		TCATGGACTACGTCCAGCTGC	0.602													8	17					0	0	0	0	T	51117039	T	T	51117039	2	4	271	1	0	0	0	0	0	0	0	1	14331	547	19	1		1	SHANK3	22	51117039	Silent	SNP	C	TCGA-CX-7082-01A-11D-2012-08	400681	51117039	187527	108	49241											
ABCB7	22	broad.mit.edu	37	chrX	74288843	74288843	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttctgtttttaaataccTgaggtaccactcccactgcc	8	16	5	12	0	1	1	0	1	1	0	2	1	2	1	4	1	3	2	4	1	4	7			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chrX:74288843T>C	uc004eca.2	-	12	1683	c.1658A>G	c.(1657-1659)CAG>CGG	p.Q553R	ABCB7_uc004ebz.2_Missense_Mutation_p.Q554R|ABCB7_uc011mqn.1_Missense_Mutation_p.Q527R|ABCB7_uc010nls.2_Missense_Mutation_p.Q514R|ABCB7_uc010nlt.2_Missense_Mutation_p.Q513R	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	553	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						TTTAAATACCTGAGGTACCAC	0.403													3	73					0	0	0	0	C	74288843	C	C	74288843	3	2	271	1	0	0	0	0	1	0	0	0	46	1594	55	5	620	5	ABCB7	23	74288843	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08		74288843	80981717	109	49242											
RBM41	55285	broad.mit.edu	37	chrX	106358744	106358744	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttcttcaatatcttgaaGacggttctgtattgcttcag	8	17	7	9	1	5	2	2	1	3	1	5	2	5	2	1	1	1	3	1	1	4	8			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chrX:106358744G>C	uc004emz.2	-	4	392	c.361C>G	c.(361-363)CTT>GTT	p.L121V	RBM41_uc004emy.1_Missense_Mutation_p.L121V	NM_018301	NP_060771	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	121							nucleotide binding|RNA binding			ovary(1)	1						ATATCTTGAAGACGGTTCTGT	0.463													32	13					0	0	0	0	C	106358744	C	C	106358744	3	2	271	1	0	0	0	0	1	0	0	0	13200	942	33	2	905	2	RBM41	23	106358744	Missense_Mutation	SNP	G	TCGA-CX-7082-01A-11D-2012-08	32069901	106358744	48911816	110	49243											
TMLHE	55217	broad.mit.edu	37	chrX	154736595	154736595	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttattccatgggtagataTttaagactggcccaatccca	11	13	7	10	0	0	2	0	0	0	2	2	2	2	2	3	2	0	1	3	2	5	7			TCGA-CX-7082-01A-11D-2012-08	TCGA-CX-7082-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4c6c96b8-958e-4235-9673-8bf4ce0e6b38	9cf2fe5e-2262-4970-892a-5c0e5571a4d6	g.chrX:154736595T>C	uc004fnn.2	-	6	1125	c.959A>G	c.(958-960)AAT>AGT	p.N320S	TMLHE_uc004fno.2_Missense_Mutation_p.N320S|TMLHE_uc004fnp.3_Missense_Mutation_p.N320S	NM_018196	NP_060666	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	320					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	TGGGTAGATATTTAAGACTGG	0.373													70	14					0	0	0	0	C	154736595	C	C	154736595	3	2	271	1	0	0	0	0	1	0	0	0	16298	1493	52	5	458	5	TMLHE	23	154736595	Missense_Mutation	SNP	T	TCGA-CX-7082-01A-11D-2012-08	48377851	154736595	533965	111	49244											
NBPF1	55672	broad.mit.edu	37	chr1	16907249	16907249	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagaggctacctgggagaaTgtttacagcatcctgacatt	12	11	10	8	0	0	3	0	1	0	2	1	4	1	3	2	2	3	3	2	2	4	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:16907249T>C	uc009vos.1	-	16	2470	c.1582A>G	c.(1582-1584)ATT>GTT	p.I528V	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Intron|NBPF1_uc010oce.1_Missense_Mutation_p.I257V	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	528	NBPF 2.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CCTGGGAGAATGTTTACAGCA	0.423													14	649					0	0	0	0	C	16907249	C	C	16907249	3	2	272	1	0	0	0	0	1	0	0	0	10245	1464	51	5	1898	5	NBPF1	1	16907249	Missense_Mutation	SNP	T	TCGA-CX-7085-01A-21D-2012-08		16907249	232343372	1	49245											
IQCC	55721	broad.mit.edu	37	chr1	32673134	32673134	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagcaagtctggaccaccGtcgtctataccatcaaacag	13	8	7	13	2	3	0	1	0	2	0	4	1	3	1	3	1	4	1	3	1	5	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:32673134G>A	uc001bum.2	+	5	899	c.852G>A	c.(850-852)CCG>CCA	p.P284P	IQCC_uc009vua.2_Silent_p.P364P|IQCC_uc010ogz.1_Silent_p.P184P|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	284										ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CTGGACCACCGTCGTCTATAC	0.537													10	57					0	0	0	0	A	32673134	A	A	32673134	2	1	272	1	0	0	0	0	0	0	0	1	7843	1132	40	1		1	IQCC	1	32673134	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	15765885	32673134	216577487	2	49246											
OSCP1	127700	broad.mit.edu	37	chr1	36909632	36909632	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgtccacctctgtccattCatctacatgaagcatacaaa	12	12	4	13	0	4	1	1	1	3	0	6	1	6	1	3	0	3	1	3	0	4	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:36909632C>T	uc001cap.2	-	2	197	c.115G>A	c.(115-117)GAA>AAA	p.E39K	OSCP1_uc001caq.2_Intron|OSCP1_uc001car.2_Intron	NM_145047	NP_659484	Q8WVF1	OSCP1_HUMAN	oxidored-nitro domain-containing protein isoform	39					transport	basal plasma membrane				ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCTGTCCATTCATCTACATGA	0.418													10	129					0	0	0	0	T	36909632	T	T	36909632	3	4	272	1	0	0	0	0	1	0	0	0	11340	841	29	2		2	OSCP1	1	36909632	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	4236498	36909632	212340989	3	49247											
GLIS1	148979	broad.mit.edu	37	chr1	54060498	54060498	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtggcgaggcttcggcccggGaggtccaggtctgggtgcag	4	7	20	10	3	1	0	0	0	1	0	3	2	2	1	2	7	1	2	2	7	0	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:54060498G>A	uc001cvr.1	-	3	645	c.78C>T	c.(76-78)CTC>CTT	p.L26L		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	26					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTCGGCCCGGGAGGTCCAGGT	0.706													3	11					0	0	0	0	A	54060498	A	A	54060498	2	1	272	1	0	0	0	0	0	0	0	1	6482	1161	41	2		2	GLIS1	1	54060498	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	17150866	54060498	195190123	4	49248											
LRIG2	9860	broad.mit.edu	37	chr1	113657399	113657399	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacagttggcattgtcatcAttgttgtggtctgctgtgtt	5	17	11	8	0	3	0	2	0	1	0	3	0	3	0	1	2	1	5	1	2	0	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:113657399A>G	uc001edf.1	+	15	2629	c.2431A>G	c.(2431-2433)ATT>GTT	p.I811V	LRIG2_uc009wgn.1_Missense_Mutation_p.I708V	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	811	Helical; (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		CATTGTCATCATTGTTGTGGT	0.423													14	95					0	0	0	0	G	113657399	G	G	113657399	3	3	272	1	0	0	0	0	1	0	0	0	8995	217	8	5	2489	5	LRIG2	1	113657399	Missense_Mutation	SNP	A	TCGA-CX-7085-01A-21D-2012-08	59596901	113657399	135593222	5	49249											
TTF2	8458	broad.mit.edu	37	chr1	117644143	117644143	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcagagtcctttttggcatCtaacctcctgtggataaggg	8	13	10	10	0	2	1	1	0	1	1	4	2	4	2	3	3	1	1	3	3	2	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:117644143C>T	uc001egy.2	+	23	3506	c.3486C>T	c.(3484-3486)ATC>ATT	p.I1162I		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	1162					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TTTTTGGCATCTAACCTCCTG	0.443													22	201					0	0	0	0	T	117644143	T	T	117644143	2	4	272	1	0	0	0	0	0	0	0	1	16787	903	32	2		2	TTF2	1	117644143	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	3986744	117644143	131606478	6	49250											
HIST2H2BF	440689	broad.mit.edu	37	chr1	149783657	149783657	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aggcgggacgcctctcccgcGatgcgctcgaagatgtcgtt	6	8	14	13	7	1	1	0	0	1	1	4	4	1	2	2	2	1	2	2	2	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:149783657G>C	uc001esr.2	-	1	272	c.222C>G	c.(220-222)ATC>ATG	p.I74M	HIST2H2BF_uc010pbj.1_Missense_Mutation_p.I74M|HIST2H2BF_uc010pbk.1_Missense_Mutation_p.I74M	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	74					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					CCTCTCCCGCGATGCGCTCGA	0.642													6	124					0	0	0	0	C	149783657	C	C	149783657	3	2	272	1	0	0	0	0	1	0	0	0	7219	1048	37	3	579	3	HIST2H2BF	1	149783657	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	32139514	149783657	99466964	7	49251											
ANXA9	8416	broad.mit.edu	37	chr1	150956843	150956843	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcccacagcccagtttgaCgcccaggaattgaggacagc	11	5	11	14	1	0	2	0	2	0	0	0	4	0	4	3	2	3	1	3	2	1	2	rs150030788		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:150956843C>T	uc001ewa.2	+	6	824	c.354C>T	c.(352-354)GAC>GAT	p.D118D		NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9	118	Annexin 2.				cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCAGTTTGACGCCCAGGAAT	0.552													8	115					0	0	0	0	T	150956843	T	T	150956843	2	4	272	1	0	0	0	0	0	0	0	1	725	535	19	1		1	ANXA9	1	150956843	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	1173186	150956843	98293778	8	49252											
SH2D2A	9047	broad.mit.edu	37	chr1	156779022	156779022	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgggacaggcctggaccaGctcttccgtaggacagggtg	7	7	15	12	1	1	0	0	0	1	0	2	3	2	3	4	5	1	2	4	5	1	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:156779022G>A	uc001fqd.2	-	7	1115	c.975C>T	c.(973-975)AGC>AGT	p.S325S	SH2D2A_uc001fqc.1_Silent_p.S297S|SH2D2A_uc009wsh.2_Silent_p.S335S|SH2D2A_uc001fqe.2_Silent_p.S307S|SH2D2A_uc010phs.1_Silent_p.S325S	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	325	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCTGGACCAGCTCTTCCGTA	0.612													17	226					0	0	0	0	A	156779022	A	A	156779022	2	1	272	1	0	0	0	0	0	0	0	1	14297	962	34	4		4	SH2D2A	1	156779022	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	5822179	156779022	92471599	9	49253											
OR2T6	254879	broad.mit.edu	37	chr1	248551279	248551279	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatggcctatgaccgctacGtggccatctgcaacccactg	8	9	9	15	2	2	1	1	1	1	0	2	1	2	1	4	2	3	2	4	2	3	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:248551279G>A	uc001iei.1	+	1	370	c.370G>A	c.(370-372)GTG>ATG	p.V124M		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGACCGCTACGTGGCCATCTG	0.567													10	68					0	0	0	0	A	248551279	A	A	248551279	3	1	272	1	0	0	0	0	1	0	0	0	11083	1145	40	1	372	1	OR2T6	1	248551279	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	91772257	248551279	699342	10	49254											
SOS1	6654	broad.mit.edu	37	chr2	39234174	39234174	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacatgtagaaacctacctCaaatgtgtggtctagtctgt	12	12	8	9	0	3	1	1	0	2	1	3	1	3	1	2	1	2	1	2	1	5	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:39234174C>G	uc002rrk.3	-	16	2712	c.2671G>C	c.(2671-2673)GAG>CAG	p.E891Q	SOS1_uc002rrj.3_Missense_Mutation_p.E505Q	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	891	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				AAACCTACCTCAAATGTGTGG	0.284									Noonan_syndrome				3	87					0	0	0	0	G	39234174	G	G	39234174	3	3	272	1	0	0	0	0	1	0	0	0	15000	835	29	2	1362	2	SOS1	2	39234174	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08		39234174	203965199	11	49255											
SOS1	6654	broad.mit.edu	37	chr2	39234255	39234255	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accattaaagttgttcaactCttgaaagacttgtagaatct	14	14	6	7	0	3	3	1	1	2	2	3	3	3	3	1	0	1	3	1	0	6	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:39234255C>G	uc002rrk.3	-	16	2631	c.2590G>C	c.(2590-2592)GAG>CAG	p.E864Q	SOS1_uc002rrj.3_Missense_Mutation_p.E478Q	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	864	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				TTGTTCAACTCTTGAAAGACT	0.358									Noonan_syndrome				11	126					0	0	0	0	G	39234255	G	G	39234255	3	3	272	1	0	0	0	0	1	0	0	0	15000	922	32	2	1443	2	SOS1	2	39234255	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	81	39234255	203965118	12	49256											
KDM3A	55818	broad.mit.edu	37	chr2	86693679	86693679	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcagcctaagacaaacactGatcaggaaaacagattggag	17	6	9	9	0	2	3	2	1	0	2	2	5	2	5	1	2	3	0	1	2	4	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:86693679G>A	uc002sri.3	+	10	1519	c.1192G>A	c.(1192-1194)GAT>AAT	p.D398N	KDM3A_uc010ytj.1_Missense_Mutation_p.D398N|KDM3A_uc010ytk.1_Missense_Mutation_p.D346N	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	398					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						GACAAACACTGATCAGGAAAA	0.453													15	169					0	0	0	0	A	86693679	A	A	86693679	3	1	272	1	0	0	0	0	1	0	0	0	8165	1290	45	2	1226	2	KDM3A	2	86693679	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	47459424	86693679	156505694	13	49257											
MITD1	129531	broad.mit.edu	37	chr2	99797402	99797402	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgctttagcacagtggctgCagctgtgctctgcgggtcct	4	11	13	13	2	1	0	0	0	1	0	2	0	2	0	2	2	5	6	2	2	1	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:99797402C>T	uc002szs.1	-	1	91	c.43G>A	c.(43-45)GCA>ACA	p.A15T	MRPL30_uc002szl.1_Intron|MRPL30_uc002szr.2_Intron|MRPL30_uc002szt.1_5'Flank|MRPL30_uc002szu.2_5'Flank|MRPL30_uc002szv.2_5'Flank	NM_138798	NP_620153	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport,	15	MIT.				protein transport	late endosome membrane				large_intestine(1)|ovary(1)	2						ACAGTGGCTGCAGCTGTGCTC	0.587													5	57					0	0	0	0	T	99797402	T	T	99797402	3	4	272	1	0	0	0	0	1	0	0	0	9648	710	25	4	734	4	MITD1	2	99797402	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	13103723	99797402	143401971	14	49258											
EIF5B	9669	broad.mit.edu	37	chr2	100007051	100007051	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accactatagatgtcatcttGatcaatgggcgtttgaagga	12	12	10	7	1	3	3	2	2	1	1	3	4	3	4	1	2	0	1	1	2	4	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:100007051G>C	uc002tab.2	+	17	2815	c.2631G>C	c.(2629-2631)TTG>TTC	p.L877F		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	877					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						ATGTCATCTTGATCAATGGGC	0.438													3	80					0	0	0	0	C	100007051	C	C	100007051	3	2	272	1	0	0	0	0	1	0	0	0	5068	1281	45	2	2697	2	EIF5B	2	100007051	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	209649	100007051	143192322	15	49259											
BAZ2B	29994	broad.mit.edu	37	chr2	160229587	160229587	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccatgccttctacaaaaatCcccccacattggggaagaat	13	9	6	13	0	1	1	0	0	1	1	3	2	3	2	5	2	2	0	5	2	5	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:160229587C>T	uc002uao.2	-	27	4534	c.4182G>A	c.(4180-4182)GGG>GGA	p.G1394G	BAZ2B_uc002uap.2_Silent_p.G1358G	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CTACAAAAATCCCCCCACATT	0.403													4	49					0	0	0	0	T	160229587	T	T	160229587	2	4	272	1	0	0	0	0	0	0	0	1	1334	842	30	2		2	BAZ2B	2	160229587	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	60222536	160229587	82969786	16	49260											
LRP2	4036	broad.mit.edu	37	chr2	170050332	170050332	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tcattatcaccgtcacagatCcattcgcttgggatgcacct	9	12	7	13	2	3	1	3	0	0	1	5	2	4	2	3	1	1	2	3	1	1	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:170050332C>G	uc002ues.2	-	47	8982	c.8769G>C	c.(8767-8769)TGG>TGC	p.W2923C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2923	LDL-receptor class A 21.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CGTCACAGATCCATTCGCTTG	0.463													5	98					0	0	0	0	G	170050332	G	G	170050332	3	3	272	1	0	0	0	0	1	0	0	0	9006	856	30	2	5330	2	LRP2	2	170050332	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	9820745	170050332	73149041	17	49261											
NAB1	4664	broad.mit.edu	37	chr2	191524404	191524404	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaaggccaccatgccactGagagcgagcacagcctctcc	10	4	11	16	1	1	1	0	1	1	1	2	3	1	1	5	2	4	2	5	2	1	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:191524404G>A	uc002usb.2	+	4	1074	c.502G>A	c.(502-504)GAG>AAG	p.E168K	NAB1_uc010fsc.2_Missense_Mutation_p.E168K|NAB1_uc010fsd.2_Missense_Mutation_p.E168K|NAB1_uc002usc.2_Missense_Mutation_p.E168K|NAB1_uc010zgh.1_Missense_Mutation_p.E168K	NM_005966	NP_005957	Q13506	NAB1_HUMAN	NGFI-A binding protein 1	168					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			CCATGCCACTGAGAGCGAGCA	0.627													7	40					0	0	0	0	A	191524404	A	A	191524404	3	1	272	1	0	0	0	0	1	0	0	0	10184	1291	45	2	504	2	NAB1	2	191524404	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	21474072	191524404	51674969	18	49262											
CASP8	841	broad.mit.edu	37	chr2	202151270	202151270	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatggggaaacagatgcctCagcctactttcacactaaga	14	8	8	11	0	2	2	2	0	0	2	2	3	2	3	2	2	4	0	2	2	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:202151270C>T	uc002uxr.1	+	10	1602	c.1393C>T	c.(1393-1395)CAG>TAG	p.Q465*	CASP8_uc002uxp.1_Nonsense_Mutation_p.Q482*|CASP8_uc002uxq.1_Nonsense_Mutation_p.Q450*|CASP8_uc002uxt.1_Nonsense_Mutation_p.Q524*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.Q450*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.Q381*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	465					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						ACAGATGCCTCAGCCTACTTT	0.313										HNSCC(4;0.00038)			7	40					0	0	0	0	T	202151270	T	T	202151270	4	4	272	1	0	0	0	0	0	1	0	0	2689	827	29	2	1704	2	CASP8	2	202151270	Nonsense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	10626866	202151270	41048103	19	49263											
WDR12	55759	broad.mit.edu	37	chr2	203772641	203772641	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactaaggtcggcaatttcaGaggcagcagggattgagaag	13	8	14	6	1	1	2	1	1	0	2	2	4	1	3	0	4	2	3	0	4	4	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:203772641G>C	uc002uzl.2	-	2	833	c.83C>G	c.(82-84)TCT>TGT	p.S28C	WDR12_uc010ftt.2_Missense_Mutation_p.S28C	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	28					cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						GGCAATTTCAGAGGCAGCAGG	0.373													3	38					0	0	0	0	C	203772641	C	C	203772641	3	2	272	1	0	0	0	0	1	0	0	0	17342	942	33	2	1236	2	WDR12	2	203772641	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	1621371	203772641	39426732	20	49264											
SMARCAL1	50485	broad.mit.edu	37	chr2	217279568	217279568	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccattgctggcaacccattCcaggccaagcaaggcccatc	10	7	8	16	0	0	0	0	0	0	0	3	0	2	0	5	3	3	3	5	3	3	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:217279568C>T	uc002vgc.3	+	3	471	c.141C>T	c.(139-141)TTC>TTT	p.F47F	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Silent_p.F47F|SMARCAL1_uc010fvg.2_Silent_p.F47F	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	47					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		GCAACCCATTCCAGGCCAAGC	0.507									Schimke_Immuno-Osseous_Dysplasia				14	181					0	0	0	0	T	217279568	T	T	217279568	2	4	272	1	0	0	0	0	0	0	0	1	14837	854	30	2		2	SMARCAL1	2	217279568	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	13506927	217279568	25919805	21	49265											
COL6A3	1293	broad.mit.edu	37	chr2	238283539	238283539	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tactgcaccacggccacgcgGacccggtcctggcccacatc	7	5	10	19	4	0	0	0	0	0	0	2	1	1	1	5	4	2	1	5	4	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:238283539G>A	uc002vwl.2	-	8	3480	c.3195C>T	c.(3193-3195)GTC>GTT	p.V1065V	COL6A3_uc002vwo.2_Silent_p.V859V|COL6A3_uc010znj.1_Silent_p.V458V|COL6A3_uc002vwq.2_Silent_p.V859V|COL6A3_uc002vwr.2_Silent_p.V658V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1065	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CGGCCACGCGGACCCGGTCCT	0.592													9	79					0	0	0	0	A	238283539	A	A	238283539	2	1	272	1	0	0	0	0	0	0	0	1	3716	1161	41	2		2	COL6A3	2	238283539	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	21003971	238283539	4915834	22	49266											
TREX1	11277	broad.mit.edu	37	chr3	48508971	48508971	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcagtagccacactgtatgGactatccctggccacacctg	9	8	10	14	0	0	0	0	0	0	0	1	1	1	1	4	3	1	3	4	3	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:48508971G>A	uc003ctj.2	+	2	2339	c.1082G>A	c.(1081-1083)GGA>GAA	p.G361E	TREX1_uc010hjy.2_Missense_Mutation_p.G306E|TREX1_uc003ctk.2_Missense_Mutation_p.G167E|TREX1_uc010hjz.2_Missense_Mutation_p.G306E|TREX1_uc010hka.2_Missense_Mutation_p.G361E	NM_033629	NP_338599	Q9NSU2	TREX1_HUMAN	three prime repair exonuclease 1 isoform b	361			G -> A (in systemic lupus erythematosus).		cell death|DNA recombination|DNA replication|mismatch repair	nuclear envelope	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|metal ion binding|MutLalpha complex binding|MutSalpha complex binding|protein homodimerization activity|single-stranded DNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		ACACTGTATGGACTATCCCTG	0.592								Direct_reversal_of_damage|Editing_and_processing_nucleases					6	59					0	0	0	0	A	48508971	A	A	48508971	3	1	272	1	0	0	0	0	1	0	0	0	16543	1174	41	2	1084	2	TREX1	3	48508971	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08		48508971	149513459	23	49267											
DALRD3	55152	broad.mit.edu	37	chr3	49053656	49053656	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agtggggtacagaccttgttCcatactacacttgtaactct	10	13	8	10	0	1	1	0	0	1	1	2	1	2	1	2	2	4	3	2	2	4	7			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:49053656C>G	uc003cvk.1	-	9	1284	c.1264G>C	c.(1264-1266)GAA>CAA	p.E422Q	DALRD3_uc003cvl.1_Missense_Mutation_p.E422Q|DALRD3_uc003cvm.1_Missense_Mutation_p.E255Q|DALRD3_uc010hko.1_Missense_Mutation_p.E255Q|DALRD3_uc011bca.1_Missense_Mutation_p.E422Q	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	422					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGACCTTGTTCCATACTACAC	0.502													6	67					0	0	0	0	G	49053656	G	G	49053656	3	3	272	1	0	0	0	0	1	0	0	0	4246	864	30	2	383	2	DALRD3	3	49053656	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	544685	49053656	148968774	24	49268											
RASSF1	11186	broad.mit.edu	37	chr3	50369058	50369058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catccaccaccaagaactttCgcagcagggcctcaatgact	12	7	7	15	1	1	2	1	1	0	1	3	2	2	2	4	1	2	2	4	1	3	1	rs148222115	byFrequency	TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:50369058C>T	uc003dad.1	-	4	835	c.704G>A	c.(703-705)CGA>CAA	p.R235Q	RASSF1_uc003daa.1_Missense_Mutation_p.R80Q|RASSF1_uc003dab.1_Missense_Mutation_p.R161Q|RASSF1_uc003dac.2_Missense_Mutation_p.R80Q|RASSF1_uc003dae.1_Missense_Mutation_p.R231Q|RASSF1_uc010hlk.1_RNA|RASSF1_uc003daf.1_Missense_Mutation_p.R80Q	NM_170714	NP_733832	Q9NS23	RASF1_HUMAN	Ras association domain family 1 isoform D	235	Ras-associating.				cell cycle arrest|negative regulation of cell cycle arrest|positive regulation of protein ubiquitination|protein stabilization|Ras protein signal transduction|response to DNA damage stimulus	microtubule|microtubule cytoskeleton|microtubule organizing center|nucleus|spindle pole	identical protein binding|protein binding|protein N-terminus binding|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000278)|OV - Ovarian serous cystadenocarcinoma(275;0.0015)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CAAGAACTTTCGCAGCAGGGC	0.597													11	77					0	0	0	0	T	50369058	T	T	50369058	3	4	272	1	0	0	0	0	1	0	0	0	13149	884	31	1	342	1	RASSF1	3	50369058	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	1315402	50369058	147653372	25	49269											
PRICKLE2	166336	broad.mit.edu	37	chr3	64145632	64145632	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttacctgttcacaaatagctCctgtcatggtgactgggaaa	11	12	9	9	0	2	1	2	1	0	0	3	2	3	2	2	2	2	2	2	2	4	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:64145632C>T	uc003dmf.2	-	4	966	c.380G>A	c.(379-381)GGA>GAA	p.G127E		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	127						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		ACAAATAGCTCCTGTCATGGT	0.438													15	151					0	0	0	0	T	64145632	T	T	64145632	3	4	272	1	0	0	0	0	1	0	0	0	12549	855	30	2	2174	2	PRICKLE2	3	64145632	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	13776574	64145632	133876798	26	49270											
GPR156	165829	broad.mit.edu	37	chr3	119885902	119885902	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccagcgtgggtttcaagtCatctttgaagttcacaatag	11	12	9	9	1	4	1	3	1	1	0	4	1	4	1	1	1	1	2	1	1	4	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:119885902C>T	uc011bjf.1	-	9	2422	c.2422G>A	c.(2422-2424)GAC>AAC	p.D808N	GPR156_uc011bjg.1_Missense_Mutation_p.D804N	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	808	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		GGTTTCAAGTCATCTTTGAAG	0.537													9	300					0	0	0	0	T	119885902	T	T	119885902	3	4	272	1	0	0	0	0	1	0	0	0	6699	826	29	2	26	2	GPR156	3	119885902	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	55740270	119885902	78136528	27	49271											
MYLK	4638	broad.mit.edu	37	chr3	123452808	123452808	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcttgcggcctgcagggtGatggagctggaagtcttctg	6	11	15	9	1	3	1	0	1	3	0	3	3	3	3	1	4	3	2	1	4	1	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:123452808G>A	uc003ego.2	-	10	1317	c.1035C>T	c.(1033-1035)ATC>ATT	p.I345I	MYLK_uc011bjw.1_Silent_p.I345I|MYLK_uc003egp.2_Silent_p.I345I|MYLK_uc003egq.2_Silent_p.I345I|MYLK_uc003egr.2_Silent_p.I345I|MYLK_uc003egs.2_Silent_p.I169I	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	345					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCTGCAGGGTGATGGAGCTGG	0.637													7	116					0	0	0	0	A	123452808	A	A	123452808	2	1	272	1	0	0	0	0	0	0	0	1	10109	1280	45	2		2	MYLK	3	123452808	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	3566906	123452808	74569622	28	49272											
SEC61A1	29927	broad.mit.edu	37	chr3	127786876	127786876	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgatgagaggccaccgagaGacctccatggtccatgaact	11	7	12	11	1	0	4	0	3	0	2	2	7	2	4	5	2	1	0	5	2	1	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:127786876G>C	uc003ekb.2	+	11	1402	c.1218G>C	c.(1216-1218)GAG>GAC	p.E406D	RUVBL1_uc003eke.2_Intron|RUVBL1_uc003ekf.2_Intron|SEC61A1_uc003ekc.2_Missense_Mutation_p.E353D|SEC61A1_uc003ekd.2_Missense_Mutation_p.E286D|SEC61A1_uc003ekg.2_Missense_Mutation_p.E100D	NM_013336	NP_037468	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit	406	Cytoplasmic (Potential).				protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			ovary(1)	1						GCCACCGAGAGACCTCCATGG	0.572											OREG0015775	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	74					0	0	0	0	C	127786876	C	C	127786876	3	2	272	1	0	0	0	0	1	0	0	0	14065	933	33	2	1260	2	SEC61A1	3	127786876	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	4334068	127786876	70235554	29	49273											
ACAD9	28976	broad.mit.edu	37	chr3	128631364	128631364	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccagatgctccagaaaacCtagatgagcagattaagaaa	17	7	8	9	0	0	6	0	1	0	5	2	6	2	6	3	0	3	2	3	0	5	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:128631364C>G	uc003ela.3	+	18	1982	c.1780C>G	c.(1780-1782)CTA>GTA	p.L594V	KIAA1257_uc003elg.1_Intron|ACAD9_uc011bks.1_Missense_Mutation_p.L471V|ACAD9_uc003elb.2_Missense_Mutation_p.L471V|ACAD9_uc003eld.1_RNA|ACAD9_uc003ele.2_Missense_Mutation_p.L246V|uc003elf.1_Intron	NM_014049	NP_054768	Q9H845	ACAD9_HUMAN	acyl-Coenzyme A dehydrogenase family, member 9	594						mitochondrion	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			ovary(2)|central_nervous_system(1)	3						TCCAGAAAACCTAGATGAGCA	0.502													12	57					0	0	0	0	G	128631364	G	G	128631364	3	3	272	1	0	0	0	0	1	0	0	0	111	680	24	4	1850	4	ACAD9	3	128631364	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	844488	128631364	69391066	30	49274											
HLTF	6596	broad.mit.edu	37	chr3	148781309	148781309	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgttcactacatctagatgCgtctatttcaaagaaaaatg	14	14	6	7	1	4	2	2	0	2	2	4	2	4	2	0	0	2	1	0	0	6	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:148781309C>T	uc003ewq.1	-	10	1287	c.1069G>A	c.(1069-1071)GCA>ACA	p.A357T	HLTF_uc003ewr.1_Missense_Mutation_p.A357T|HLTF_uc003ews.1_Missense_Mutation_p.A357T|HLTF_uc010hve.1_Missense_Mutation_p.A357T	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	357					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CATCTAGATGCGTCTATTTCA	0.343													5	58					0	0	0	0	T	148781309	T	T	148781309	3	4	272	1	0	0	0	0	1	0	0	0	7254	768	27	1	2024	1	HLTF	3	148781309	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	20149945	148781309	49241121	31	49275											
SMC4	10051	broad.mit.edu	37	chr3	160149430	160149430	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccctaaattgaacttttaGatttcaaaaatatcactgca	15	14	3	9	0	2	2	2	1	0	1	3	2	3	2	2	0	2	1	2	0	7	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:160149430G>A	uc003fdh.2	+	21	3228	c.3115_splice	c.e21-1	p.I1039_splice	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Splice_Site_p.I1014_splice|SMC4_uc003fdj.2_Splice_Site_p.I1039_splice|SMC4_uc010hwd.2_Splice_Site_p.I981_splice|SMC4_uc003fdl.2_Splice_Site_p.I742_splice	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes						cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TGAACTTTTAGATTTCAAAAA	0.313													4	66					0	0	0	0	A	160149430	A	A	160149430	5	1	272	1	0	0	0	0	0	0	1	0	14849	956	33	2	3192	2	SMC4	3	160149430	Splice_Site	SNP	G	TCGA-CX-7085-01A-21D-2012-08	11368121	160149430	37873000	32	49276											
TTC14	151613	broad.mit.edu	37	chr3	180321060	180321060	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcggttttttcatggtgttGatctgtttaggaagtggtat	6	20	12	3	1	2	1	1	1	1	0	3	2	2	2	0	4	0	4	0	4	3	8			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:180321060G>A	uc003fkk.2	+	3	567	c.435G>A	c.(433-435)TTG>TTA	p.L145L	TTC14_uc003fkl.2_Silent_p.L145L|TTC14_uc003fkm.2_Silent_p.L145L	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	145	S1 motif.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TCATGGTGTTGATCTGTTTAG	0.373													5	88					0	0	0	0	A	180321060	A	A	180321060	2	1	272	1	0	0	0	0	0	0	0	1	16749	1281	45	2		2	TTC14	3	180321060	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	20171630	180321060	17701370	33	49277											
FGFR3	2261	broad.mit.edu	37	chr4	1801486	1801486	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccttgcagacgctccatcctCgggagatgacgaagacgggg	9	6	14	12	4	0	4	0	1	0	3	3	6	2	4	3	3	1	2	3	3	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:1801486C>T	uc003gdr.3	+	4	648	c.392C>T	c.(391-393)TCG>TTG	p.S131L	FGFR3_uc003gdu.2_Missense_Mutation_p.S131L|FGFR3_uc003gds.3_Missense_Mutation_p.S131L|FGFR3_uc003gdq.3_Missense_Mutation_p.S131L|FGFR3_uc010icb.1_5'Flank|FGFR3_uc003gdt.1_5'Flank	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	131	Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S131L(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GCTCCATCCTCGGGAGATGAC	0.677		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				5	40					0	0	0	0	T	1801486	T	T	1801486	3	4	272	1	0	0	0	0	1	0	0	0	5899	893	31	1	402	1	FGFR3	4	1801486	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08		1801486	189352790	34	49278											
CCKAR	886	broad.mit.edu	37	chr4	26490898	26490898	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaacggcgctcccgaagatGaaatccttgagcagattggg	12	7	12	10	3	0	4	0	2	0	2	2	5	2	4	2	2	2	2	2	2	3	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:26490898G>T	uc003gse.1	-	2	474	c.321C>A	c.(319-321)TTC>TTA	p.F107L		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	107	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	TCCCGAAGATGAAATCCTTGA	0.562													7	115					8.12818e-05	0.000383071	1	0	T	26490898	T	T	26490898	3	4	272	1	0	0	0	0	1	0	0	0	2893	1281	45	2	981	2	CCKAR	4	26490898	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	24689412	26490898	164663378	35	49279											
PDGFRA	5156	broad.mit.edu	37	chr4	55144560	55144560	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcatcacagagtattgcttCtatggagatttggtcaacta	12	14	8	7	0	4	2	3	0	1	2	4	3	4	2	0	2	2	2	0	2	4	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:55144560C>G	uc003han.3	+	15	2365	c.2034C>G	c.(2032-2034)TTC>TTG	p.F678L	PDGFRA_uc003haa.2_Missense_Mutation_p.F438L|PDGFRA_uc010igq.1_Missense_Mutation_p.F572L|PDGFRA_uc003ham.2_RNA|PDGFRA_uc003hao.1_Missense_Mutation_p.F57L	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	678	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	AGTATTGCTTCTATGGAGATT	0.433			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			4	88					0	0	0	0	G	55144560	G	G	55144560	3	3	272	1	0	0	0	0	1	0	0	0	11715	912	32	2	2088	2	PDGFRA	4	55144560	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	28653662	55144560	136009716	36	49280											
UGT2B11	10720	broad.mit.edu	37	chr4	70074139	70074139	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcatgttacttatcactGaccccagagaaaacaccaca	14	9	5	13	0	2	2	2	1	0	1	2	3	2	2	3	0	2	1	3	0	4	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:70074139G>A	uc003heh.2	-	3	941	c.932C>T	c.(931-933)TCA>TTA	p.S311L	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	311					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						ACTTATCACTGACCCCAGAGA	0.418													19	189					0	0	0	0	A	70074139	A	A	70074139	3	1	272	1	0	0	0	0	1	0	0	0	17025	1294	45	2	673	2	UGT2B11	4	70074139	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	14929579	70074139	121080137	37	49281											
USO1	8615	broad.mit.edu	37	chr4	76708301	76708301	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccagtgtgggttattgcaGcagctttgtactatcctaat	8	16	9	8	0	0	0	0	0	0	0	2	0	2	0	2	1	4	5	2	1	4	7			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:76708301G>A	uc003hiu.2	+	9	1117	c.942G>A	c.(940-942)CAG>CAA	p.Q314Q	USO1_uc003hiv.2_Silent_p.Q149Q|USO1_uc003hiw.2_Silent_p.Q149Q	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	314	ARM 6.|Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GGTTATTGCAGCAGCTTTGTA	0.468													7	104					0	0	0	0	A	76708301	A	A	76708301	2	1	272	1	0	0	0	0	0	0	0	1	17107	962	34	4		4	USO1	4	76708301	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	6634162	76708301	114445975	38	49282											
NAP1L5	266812	broad.mit.edu	37	chr4	89618637	89618637	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcttctatcttatcgcatCgcttctgcagctttttgagg	5	17	9	10	2	3	1	0	1	3	0	5	1	3	1	0	2	2	5	0	2	2	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:89618637C>A	uc003hrx.2	-	1	387	c.269G>T	c.(268-270)CGA>CTA	p.R90L	HERC3_uc003hrw.1_Intron|HERC3_uc011cdn.1_Intron|HERC3_uc011cdo.1_Intron	NM_153757	NP_715638	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	90	Potential.				nucleosome assembly	nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		CTTATCGCATCGCTTCTGCAG	0.458													12	119					6.40141e-05	0.000303191	1	0	A	89618637	A	A	89618637	3	1	272	1	0	0	0	0	1	0	0	0	10213	884	31	3	283	3	NAP1L5	4	89618637	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	12910336	89618637	101535639	39	49283											
FAT4	79633	broad.mit.edu	37	chr4	126239528	126239528	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacagagaagagcaagccttCtactccctgttggttctggc	9	10	11	11	0	2	2	0	0	2	2	3	4	3	2	2	2	3	3	2	2	3	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:126239528C>G	uc003ifj.3	+	1	1962	c.1962C>G	c.(1960-1962)TTC>TTG	p.F654L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	654	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGCAAGCCTTCTACTCCCTGT	0.517													8	59					0	0	0	0	G	126239528	G	G	126239528	3	3	272	1	0	0	0	0	1	0	0	0	5724	912	32	2	1964	2	FAT4	4	126239528	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	36620891	126239528	64914748	40	49284											
SLC7A11	23657	broad.mit.edu	37	chr4	139153472	139153472	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagttcagggatttcacattGaataaaaaatggttccagaa	17	11	8	5	0	2	2	2	1	0	1	3	3	3	3	1	2	0	2	1	2	6	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:139153472G>C	uc011chb.1	-	3	749	c.469C>G	c.(469-471)CAA>GAA	p.Q157E		NM_014331	NP_055146	Q9UPY5	XCT_HUMAN	solute carrier family 7, (cationic amino acid	157	Extracellular (Potential).				blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			skin(1)	1	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	ATTTCACATTGAATAAAAAAT	0.368													10	68					0	0	0	0	C	139153472	C	C	139153472	3	2	272	1	0	0	0	0	1	0	0	0	14758	1299	45	2	1076	2	SLC7A11	4	139153472	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	12913944	139153472	52000804	41	49285											
KIAA0922	23240	broad.mit.edu	37	chr4	154544100	154544100	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgtggacaagttctgctccGattccagctctgactgtggg	6	12	13	10	1	2	1	0	1	2	0	4	3	4	2	2	2	2	3	2	2	1	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:154544100G>A	uc003inm.3	+	29	3959	c.3907G>A	c.(3907-3909)GAT>AAT	p.D1303N	KIAA0922_uc010ipp.2_Missense_Mutation_p.D1304N|KIAA0922_uc010ipq.2_Missense_Mutation_p.D1072N	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1303	Ser-rich.|Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				GTTCTGCTCCGATTCCAGCTC	0.562													14	121					0	0	0	0	A	154544100	A	A	154544100	3	1	272	1	0	0	0	0	1	0	0	0	8240	1058	37	1	4024	1	KIAA0922	4	154544100	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	15390628	154544100	36610176	42	49286											
ODZ3	55714	broad.mit.edu	37	chr4	183713749	183713749	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tacctatgatgaaacagcagGagtcctaaagacagtaaacc	17	7	8	9	0	0	3	0	2	0	1	1	4	1	4	3	1	4	2	3	1	7	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:183713749G>C	uc003ivd.1	+	25	5961	c.5924G>C	c.(5923-5925)GGA>GCA	p.G1975A		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1975	Extracellular (Potential).|YD 11.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GAAACAGCAGGAGTCCTAAAG	0.408													10	187					0	0	0	0	C	183713749	C	C	183713749	3	2	272	1	0	0	0	0	1	0	0	0	10890	1174	41	2	6022	2	ODZ3	4	183713749	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	29169649	183713749	7440527	43	49287											
FAT1	2195	broad.mit.edu	37	chr4	187516868	187516868	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcatcgcacgattcggactgGaaggagctcagagactgcac	11	7	12	11	3	2	1	2	0	0	1	4	6	2	4	0	3	2	3	0	3	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:187516868G>C	uc003izf.2	-	26	13301	c.13113C>G	c.(13111-13113)TTC>TTG	p.F4371L	FAT1_uc010isn.2_5'UTR|FAT1_uc003ize.2_Missense_Mutation_p.F262L	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4371	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATTCGGACTGGAAGGAGCTCA	0.512										HNSCC(5;0.00058)			9	90					0	0	0	0	C	187516868	C	C	187516868	3	2	272	1	0	0	0	0	1	0	0	0	5721	1165	41	2	661	2	FAT1	4	187516868	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	3803119	187516868	3637408	44	49288			1	76		2	2	14	G		7.474681e-05
FAT1	2195	broad.mit.edu	37	chr4	187516881	187516881	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggactggaaggagctcagaGactgcacttcagacaggctt	11	7	13	10	1	2	2	2	0	0	2	2	6	2	5	0	4	2	3	0	4	1	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:187516881G>C	uc003izf.2	-	26	13288	c.13100C>G	c.(13099-13101)TCT>TGT	p.S4367C	FAT1_uc010isn.2_5'UTR|FAT1_uc003ize.2_Missense_Mutation_p.S258C	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4367	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGAGCTCAGAGACTGCACTTC	0.517										HNSCC(5;0.00058)			10	90					0	0	0	0	C	187516881	C	C	187516881	3	2	272	1	0	0	0	0	1	0	0	0	5721	942	33	2	674	2	FAT1	4	187516881	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	13	187516881	3637395	45	49289			1	76		2	2	14	G		7.474681e-05
FAT1	2195	broad.mit.edu	37	chr4	187630459	187630459	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gttggttcctatgtctgcatCcgtggcgctgactcttgcga	4	14	12	11	3	2	1	0	1	2	0	4	2	4	1	2	2	2	4	2	2	1	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:187630459C>G	uc003izf.2	-	2	711	c.523G>C	c.(523-525)GAT>CAT	p.D175H	FAT1_uc010iso.1_Missense_Mutation_p.D175H	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	175	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATGTCTGCATCCGTGGCGCTG	0.433										HNSCC(5;0.00058)			20	162					0	0	0	0	G	187630459	G	G	187630459	3	3	272	1	0	0	0	0	1	0	0	0	5721	855	30	2	13347	2	FAT1	4	187630459	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	113578	187630459	3523817	46	49290											
SLC45A2	51151	broad.mit.edu	37	chr5	33963899	33963899	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catactcgtacattccatctGatgacaatggagggtcctga	11	11	9	10	1	1	3	0	3	1	0	4	4	3	4	2	2	2	1	2	2	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:33963899G>C	uc003jid.2	-	3	877	c.785C>G	c.(784-786)TCA>TGA	p.S262*	SLC45A2_uc003jie.2_Nonsense_Mutation_p.S262*|SLC45A2_uc003jif.3_Intron|SLC45A2_uc011coe.1_Intron	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	262	Cytoplasmic (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CATTCCATCTGATGACAATGG	0.443													6	117					0	0	0	0	C	33963899	C	C	33963899	4	2	272	1	0	0	0	0	0	1	0	0	14705	1294	45	2	842	2	SLC45A2	5	33963899	Nonsense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08		33963899	146951361	47	49291											
CMYA5	202333	broad.mit.edu	37	chr5	79026056	79026056	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaggaggaaaacatgcttGagccatccatttctctttct	12	12	8	9	0	2	2	0	1	2	1	4	4	3	4	2	2	3	1	2	2	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:79026056G>C	uc003kgc.2	+	2	1540	c.1468G>C	c.(1468-1470)GAG>CAG	p.E490Q		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	490	Glu-rich.					perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAACATGCTTGAGCCATCCAT	0.458													15	125					0	0	0	0	C	79026056	C	C	79026056	3	2	272	1	0	0	0	0	1	0	0	0	3605	1291	45	2	1474	2	CMYA5	5	79026056	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	45062157	79026056	101889204	48	49292											
SLCO4C1	353189	broad.mit.edu	37	chr5	101597639	101597639	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaatgttttggaaagcaaGaaaaaggtattattaaagac	19	11	9	2	0	0	2	0	0	0	2	0	3	0	3	0	2	1	4	0	2	10	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:101597639G>T	uc003knm.2	-	5	1285	c.998C>A	c.(997-999)TCT>TAT	p.S333Y		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	333	Helical; Name=6; (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TGGAAAGCAAGAAAAAGGTAT	0.368													4	39					0.00024832	0.00115883	1	0	T	101597639	T	T	101597639	3	4	272	1	0	0	0	0	1	0	0	0	14794	942	33	2	1212	2	SLCO4C1	5	101597639	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	22571583	101597639	79317621	49	49293											
SLCO6A1	133482	broad.mit.edu	37	chr5	101724493	101724493	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtaaaatacaagaagtttctCctgacattttaaagattgat	16	14	6	5	0	1	4	0	2	1	2	2	4	1	4	1	0	1	2	1	0	7	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:101724493C>T	uc003knn.2	-	12	2088	c.1916G>A	c.(1915-1917)GGA>GAA	p.G639E	SLCO6A1_uc003kno.2_Missense_Mutation_p.G386E|SLCO6A1_uc003knp.2_Missense_Mutation_p.G639E|SLCO6A1_uc003knq.2_Missense_Mutation_p.G577E	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	639	Helical; Name=11; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AGAAGTTTCTCCTGACATTTT	0.323													5	22					0	0	0	0	T	101724493	T	T	101724493	3	4	272	1	0	0	0	0	1	0	0	0	14796	855	30	2	251	2	SLCO6A1	5	101724493	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	126854	101724493	79190767	50	49294											
CSF2	1437	broad.mit.edu	37	chr5	131411512	131411512	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggactttctgcttgtcatCccctttgactgctgggagcc	6	13	10	12	0	2	1	1	1	1	0	3	3	3	3	3	2	3	2	3	2	1	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:131411512C>T	uc003kwf.2	+	4	434	c.402C>T	c.(400-402)ATC>ATT	p.I134I		NM_000758	NP_000749	P04141	CSF2_HUMAN	colony stimulating factor 2 precursor	134					immune response|negative regulation of cytolysis|positive regulation of DNA replication|positive regulation of interleukin-23 production|positive regulation of macrophage derived foam cell differentiation|positive regulation of podosome assembly|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|growth factor activity				0		all_cancers(142;4.28e-07)|all_lung(232;2.81e-05)|Lung NSC(810;0.000693)|Lung SC(612;0.122)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Sargramostim(DB00020)	TGCTTGTCATCCCCTTTGACT	0.463													5	115					0	0	0	0	T	131411512	T	T	131411512	2	4	272	1	0	0	0	0	0	0	0	1	3950	845	30	2		2	CSF2	5	131411512	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	29687019	131411512	49503748	51	49295											
PCDHA9	9752	broad.mit.edu	37	chr5	140229699	140229699	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggtgagcgcgcgcgacgCgggcgtgccgcctctgggca	4	4	18	15	8	1	1	0	1	1	0	1	2	1	1	3	3	2	1	3	3	0	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:140229699C>T	uc003lhu.2	+	1	2343	c.1619C>T	c.(1618-1620)GCG>GTG	p.A540V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.A540V	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	540	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCGACGCGGGCGTGCCG	0.667													20	154					0	0	0	0	T	140229699	T	T	140229699	3	4	272	1	0	0	0	0	1	0	0	0	11585	768	27	1	1621	1	PCDHA9	5	140229699	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	8818187	140229699	40685561	52	49296											
PCDHA13	56136	broad.mit.edu	37	chr5	140264038	140264038	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgctcggcaccgcccaccGagggcgcgtgcgcgccgggc	3	3	18	17	8	0	0	0	0	0	0	1	1	0	0	4	4	2	2	4	4	0	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:140264038G>A	uc003lif.2	+	1	2185	c.2185G>A	c.(2185-2187)GAG>AAG	p.E729K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.E729K|PCDHA13_uc003lid.2_Missense_Mutation_p.E729K	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	729	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGCCCACCGAGGGCGCGTG	0.647													6	125					0	0	0	0	A	140264038	A	A	140264038	3	1	272	1	0	0	0	0	1	0	0	0	11577	1059	37	1	2187	1	PCDHA13	5	140264038	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	34339	140264038	40651222	53	49297											
PCDHAC1	56135	broad.mit.edu	37	chr5	140306523	140306523	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgtttgtgggtttcctgcGgcgctgcagcgggacagctc	4	12	15	10	3	0	0	0	0	0	0	2	1	1	1	1	3	4	5	1	3	1	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:140306523G>A	uc003lih.2	+	1	222	c.46G>A	c.(46-48)GGC>AGC	p.G16S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.G16S	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	16					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTTTCCTGCGGCGCTGCAGC	0.642													5	47					0	0	0	0	A	140306523	A	A	140306523	3	1	272	1	0	0	0	0	1	0	0	0	11586	1116	39	1	48	1	PCDHAC1	5	140306523	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	42485	140306523	40608737	54	49298											
PCDHGA4	56111	broad.mit.edu	37	chr5	140734878	140734878	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attctctactcggtgtttgaGgagcaggaagaaggctcagt	10	11	13	7	1	2	2	1	1	1	1	4	4	2	4	0	4	2	3	0	4	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:140734878G>T	uc003ljq.1	+	1	111	c.111G>T	c.(109-111)GAG>GAT	p.E37D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.E37D	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	37	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGTGTTTGAGGAGCAGGAAG	0.632													10	80					7.48243e-07	3.57953e-06	1	0	T	140734878	T	T	140734878	3	4	272	1	0	0	0	0	1	0	0	0	11610	991	35	4	113	4	PCDHGA4	5	140734878	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	428355	140734878	40180382	55	49299											
NR3C1	2908	broad.mit.edu	37	chr5	142780167	142780178	+	In_Frame_Del	DEL	TGGACAGATCTG	-	-																															cattgagagtgaaactgcttTggacagatctggctgctgcg																										TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:142780167_142780178delTGGACAGATCTG	uc003lmz.2	-	2	719_730	c.227_238delCAGATCTGTCCA	c.(226-240)CCAGATCTGTCCAAA>CAA	p.76_80PDLSK>Q	NR3C1_uc003lmy.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lna.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lnb.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc011dbk.1_Intron|NR3C1_uc003lnc.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lnd.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lne.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lnf.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lng.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lnh.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lni.2_In_Frame_Del_p.76_80PDLSK>Q	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	76_80	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	GAAACTGCTTTGGACAGATCTGGCTGCTGCGC	0.491													---	---	---								-	142780178	-	-	142780167	7	5	272	1	0	1	0	1	0	0	0	0	10684	1821	63	0	2182	0	NR3C1	5	142780167	In_Frame_Del	DEL	TGGACAGATCTG	TCGA-CX-7085-01A-21D-2012-08	2045289	142780167	38135093	56	49300											
HIST1H2BB	3018	broad.mit.edu	37	chr6	26043604	26043604	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggcgcacagccgtctgaatCtccctggaggtgatggtcga	8	8	14	11	3	2	2	0	2	2	0	4	4	2	3	2	4	1	1	2	4	1	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:26043604C>T	uc003nfu.2	-	1	282	c.282G>A	c.(280-282)GAG>GAA	p.E94E	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	94					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CCGTCTGAATCTCCCTGGAGG	0.562													5	99					0	0	0	0	T	26043604	T	T	26043604	2	4	272	1	0	0	0	0	0	0	0	1	7180	912	32	2		2	HIST1H2BB	6	26043604	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08		26043604	145071463	57	49301											
PPP1R10	5514	broad.mit.edu	37	chr6	30571943	30571943	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctccatgttatcatggctCagacgccgcgctgtctcaaa	8	11	8	14	3	3	1	3	0	1	1	6	1	5	1	3	1	0	3	3	1	2	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:30571943C>T	uc003nqn.1	-	14	1902	c.1350G>A	c.(1348-1350)CTG>CTA	p.L450L	PPP1R10_uc010jsc.1_Silent_p.L104L	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	450	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						TATCATGGCTCAGACGCCGCG	0.562													11	158					0	0	0	0	T	30571943	T	T	30571943	2	4	272	1	0	0	0	0	0	0	0	1	12412	813	29	2		2	PPP1R10	6	30571943	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	4528339	30571943	140543124	58	49302											
C4A	720	broad.mit.edu	37	chr6	31994872	31994872	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggagctgcggcctgtcctCtataactacctggataaaaa	11	10	9	11	1	1	0	0	0	1	0	2	2	2	2	3	3	4	1	3	3	6	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:31994872C>G	uc011dpd.1	+	20	2616	c.2565C>G	c.(2563-2565)CTC>CTG	p.L855L	C4A_uc011dpe.1_Silent_p.L855L	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	855					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						GGCCTGTCCTCTATAACTACC	0.632													7	103					0	0	0	0	G	31994872	G	G	31994872	2	3	272	1	0	0	0	0	0	0	0	1	2257	900	32	2		2	C4A	6	31994872	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	1422929	31994872	139120195	59	49303											
IP6K3	117283	broad.mit.edu	37	chr6	33693275	33693275	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgctctgcgcacacttcctCatgtggcgggccttcttctc	3	13	10	15	2	4	0	1	0	3	0	6	0	5	0	2	2	2	2	2	2	0	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:33693275C>G	uc010jvf.2	-	6	1244	c.708G>C	c.(706-708)ATG>ATC	p.M236I	IP6K3_uc003ofb.2_Missense_Mutation_p.M236I	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	236					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						CACACTTCCTCATGTGGCGGG	0.632													4	40					0	0	0	0	G	33693275	G	G	33693275	3	3	272	1	0	0	0	0	1	0	0	0	7829	826	29	2	532	2	IP6K3	6	33693275	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	1698403	33693275	137421792	60	49304											
DAAM2	23500	broad.mit.edu	37	chr6	39843215	39843215	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgacctggctcccttggaGaacttcaatgtcaagaacat	11	10	8	12	0	2	3	2	1	0	2	3	4	3	3	3	2	2	1	3	2	4	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:39843215G>A	uc003oow.2	+	11	1428	c.1272G>A	c.(1270-1272)GAG>GAA	p.E424E	DAAM2_uc010jxc.2_Silent_p.E424E|DAAM2_uc003oox.2_Silent_p.E424E	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	424					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CTCCCTTGGAGAACTTCAATG	0.577													11	79					0	0	0	0	A	39843215	A	A	39843215	2	1	272	1	0	0	0	0	0	0	0	1	4233	933	33	2		2	DAAM2	6	39843215	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	6149940	39843215	131271852	61	49305											
CUL7	9820	broad.mit.edu	37	chr6	43006181	43006181	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcccatctcgacctgggttCcttgctgccatctcgaatct	5	13	8	15	2	3	0	0	0	3	0	7	2	5	0	4	1	2	2	4	1	1	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:43006181C>T	uc003otq.2	-	25	4900	c.4597G>A	c.(4597-4599)GAA>AAA	p.E1533K	CUL7_uc010jyg.2_Missense_Mutation_p.E812K|CUL7_uc011dvb.1_Missense_Mutation_p.E1617K|CUL7_uc010jyh.2_Missense_Mutation_p.E526K|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1533					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GACCTGGGTTCCTTGCTGCCA	0.567													4	62					0	0	0	0	T	43006181	T	T	43006181	3	4	272	1	0	0	0	0	1	0	0	0	4077	864	30	2	507	2	CUL7	6	43006181	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	3162966	43006181	128108886	62	49306											
SMAP1	60682	broad.mit.edu	37	chr6	71562302	71562302	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggtgccacccctgaacgatGatctggacatctttggaccg	8	9	11	13	3	2	2	0	2	2	0	2	5	2	4	4	3	2	0	4	3	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:71562302G>A	uc003pfr.2	+	8	972	c.724G>A	c.(724-726)GAT>AAT	p.D242N	SMAP1_uc003pfs.2_Missense_Mutation_p.D215N|SMAP1_uc010kao.2_Missense_Mutation_p.D215N|SMAP1_uc010kap.2_Missense_Mutation_p.D232N	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	stromal membrane-associated GTPase-activating	242					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding				0						CCTGAACGATGATCTGGACAT	0.458													10	134					0	0	0	0	A	71562302	A	A	71562302	3	1	272	1	0	0	0	0	1	0	0	0	14830	1290	45	2	754	2	SMAP1	6	71562302	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	28556121	71562302	99552765	63	49307											
C6orf204	387119	broad.mit.edu	37	chr6	118812872	118812872	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcctctagtttcttcttctCttcactaaataggcttagtc	7	19	4	11	0	5	0	1	0	4	0	8	0	6	0	1	1	0	2	1	1	5	9			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:118812872C>T	uc003pxz.1	-	6	2002	c.1414G>A	c.(1414-1416)GAG>AAG	p.E472K	C6orf204_uc003pya.1_Missense_Mutation_p.E475K|C6orf204_uc003pyb.2_Missense_Mutation_p.E472K|C6orf204_uc011ebj.1_Missense_Mutation_p.E370K|C6orf204_uc003pyc.2_Missense_Mutation_p.E475K	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	472	Potential.					centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		TTCTTCTTCTCTTCACTAAAT	0.338													4	21					0	0	0	0	T	118812872	T	T	118812872	3	4	272	1	0	0	0	0	1	0	0	0	2363	922	32	2	1089	2	C6orf204	6	118812872	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	47250570	118812872	52302195	64	49308											
LAMA2	3908	broad.mit.edu	37	chr6	129419471	129419471	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	taacgctttacaatatttatCcccgcactgggccaccgtca	10	11	6	14	3	1	0	1	0	0	0	2	0	2	0	4	1	2	2	4	1	5	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:129419471C>T	uc003qbn.2	+	4	655	c.550C>T	c.(550-552)CCC>TCC	p.P184S	LAMA2_uc003qbo.2_Missense_Mutation_p.P184S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	184	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CAATATTTATCCCCGCACTGG	0.448													10	68					0	0	0	0	T	129419471	T	T	129419471	3	4	272	1	0	0	0	0	1	0	0	0	8646	855	30	2	564	2	LAMA2	6	129419471	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	10606599	129419471	41695596	65	49309											
RAC1	5879	broad.mit.edu	37	chr7	6431563	6431563	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccattctacagctttgacaAttattctgccaatgttatgg	10	16	6	9	0	2	1	0	1	2	0	3	1	3	1	2	1	3	2	2	1	5	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:6431563A>G	uc003spx.2	+	3	357	c.116A>G	c.(115-117)AAT>AGT	p.N39S	RAC1_uc003spw.2_Missense_Mutation_p.N39S	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	39	Effector region (Potential).				actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	AGCTTTGACAATTATTCTGCC	0.438													4	64					0	0	0	0	G	6431563	G	G	6431563	3	3	272	1	0	0	0	0	1	0	0	0	13039	101	4	5	126	5	RAC1	7	6431563	Missense_Mutation	SNP	A	TCGA-CX-7085-01A-21D-2012-08		6431563	152707100	66	49310											
RAC1	5879	broad.mit.edu	37	chr7	6441974	6441974	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatacctggagtgctcggCgctcacacagcgaggcctca	11	6	11	13	3	2	0	2	0	0	0	3	2	2	1	2	3	3	2	2	3	3	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:6441974C>T	uc003spx.2	+	6	717	c.476C>T	c.(475-477)GCG>GTG	p.A159V	RAC1_uc003spw.2_Missense_Mutation_p.A178V	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	159					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	GAGTGCTCGGCGCTCACACAG	0.567													6	79					0	0	0	0	T	6441974	T	T	6441974	3	4	272	1	0	0	0	0	1	0	0	0	13039	768	27	1	559	1	RAC1	7	6441974	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	10411	6441974	152696689	67	49311											
GLI3	2737	broad.mit.edu	37	chr7	42084994	42084994	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcacttactatccatagcaTgaagatattccatgtggatg	12	13	8	8	0	1	2	1	1	0	1	3	3	3	3	2	1	2	1	2	1	5	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:42084994T>A	uc011kbh.1	-	6	906	c.815A>T	c.(814-816)CAT>CTT	p.H272L	GLI3_uc011kbg.1_Missense_Mutation_p.H213L	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	272					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ATCCATAGCATGAAGATATTC	0.502									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				23	217					0	0	0	0	A	42084994	A	A	42084994	3	1	272	1	0	0	0	0	1	0	0	0	6476	1464	51	5	3967	5	GLI3	7	42084994	Missense_Mutation	SNP	T	TCGA-CX-7085-01A-21D-2012-08	35643020	42084994	117053669	68	49312											
DTX2	113878	broad.mit.edu	37	chr7	76109854	76109854	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggccccaagcccttccctgGtgcaggtgtacaccagcccc	6	7	10	18	0	0	0	0	0	0	0	1	0	1	0	7	3	4	2	7	3	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:76109854G>T	uc003uff.3	+	4	584	c.28G>T	c.(28-30)GTG>TTG	p.V10L	DTX2_uc011kgk.1_Intron|DTX2_uc003ufg.3_Missense_Mutation_p.V10L|DTX2_uc003ufh.3_Missense_Mutation_p.V10L|DTX2_uc003ufj.3_Missense_Mutation_p.V10L	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	10	WWE 1.				Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CCCTTCCCTGGTGCAGGTGTA	0.657													4	31					0.00024832	0.00115883	1	0	T	76109854	T	T	76109854	3	4	272	1	0	0	0	0	1	0	0	0	4816	1261	44	4	30	4	DTX2	7	76109854	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	34024860	76109854	83028809	69	49313											
DMTF1	9988	broad.mit.edu	37	chr7	86815200	86815200	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaactgggatctgttagctGagggatggagtagtgtccgt	8	13	15	5	1	1	1	0	1	1	0	2	4	2	4	1	3	2	3	1	3	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:86815200G>A	uc003uih.2	+	12	1431	c.1105G>A	c.(1105-1107)GAG>AAG	p.E369K	DMTF1_uc003uii.2_Missense_Mutation_p.E103K|DMTF1_uc003uij.2_Missense_Mutation_p.E103K|DMTF1_uc011khb.1_Missense_Mutation_p.E281K|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Missense_Mutation_p.E369K|DMTF1_uc003uin.2_Missense_Mutation_p.E103K	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	369	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for DNA-binding (By similarity).|Myb-like 2.				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					TCTGTTAGCTGAGGGATGGAG	0.393													10	69					0	0	0	0	A	86815200	A	A	86815200	3	1	272	1	0	0	0	0	1	0	0	0	4614	1291	45	2	1143	2	DMTF1	7	86815200	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	10705346	86815200	72323463	70	49314											
GIGYF1	64599	broad.mit.edu	37	chr7	100281196	100281196	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgttgcagctggagttgttCtagaattggaccctgagtcg	8	13	13	7	1	1	2	0	1	1	1	2	4	1	4	1	2	2	5	1	2	2	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:100281196C>G	uc003uwg.1	-	17	3038	c.2029G>C	c.(2029-2031)GAA>CAA	p.E677Q		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	677										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TGGAGTTGTTCTAGAATTGGA	0.612													10	158					0	0	0	0	G	100281196	G	G	100281196	3	3	272	1	0	0	0	0	1	0	0	0	6414	922	32	2	1110	2	GIGYF1	7	100281196	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	13465996	100281196	58857467	71	49315											
SRRT	51593	broad.mit.edu	37	chr7	100482943	100482943	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcataagacctgctccctCttcatgcgcaacatcgcgcc	8	9	7	17	3	2	1	1	0	1	1	4	1	3	1	3	0	4	3	3	0	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:100482943C>G	uc003uwy.2	+	11	1537	c.1269C>G	c.(1267-1269)CTC>CTG	p.L423L	SRRT_uc010lhl.1_Silent_p.L422L|SRRT_uc003uxa.2_Silent_p.L422L|SRRT_uc003uwz.2_Silent_p.L423L	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	423					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						CCTGCTCCCTCTTCATGCGCA	0.622													6	61					0	0	0	0	G	100482943	G	G	100482943	2	3	272	1	0	0	0	0	0	0	0	1	15238	900	32	2		2	SRRT	7	100482943	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	201747	100482943	58655720	72	49316											
SRRT	51593	broad.mit.edu	37	chr7	100483972	100483972	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagattgtgcgcaacgacatCaagctggcggccaagctgat	11	7	12	11	3	1	2	1	1	0	1	1	3	1	2	1	2	4	3	1	2	3	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:100483972C>G	uc003uwy.2	+	14	1831	c.1563C>G	c.(1561-1563)ATC>ATG	p.I521M	SRRT_uc010lhl.1_Missense_Mutation_p.I520M|SRRT_uc003uxa.2_Missense_Mutation_p.I520M|SRRT_uc003uwz.2_Missense_Mutation_p.I521M	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	521					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GCAACGACATCAAGCTGGCGG	0.617													7	41					0	0	0	0	G	100483972	G	G	100483972	3	3	272	1	0	0	0	0	1	0	0	0	15238	816	29	2	1609	2	SRRT	7	100483972	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	1029	100483972	58654691	73	49317											
LHFPL3	375612	broad.mit.edu	37	chr7	104377175	104377175	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgatggctgggactcagatGaagtaaaacggatgtgtgga	12	9	15	5	1	1	3	1	2	0	1	1	6	1	6	0	4	1	2	0	4	3	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:104377175G>A	uc003vce.2	+	2	623	c.499G>A	c.(499-501)GAA>AAA	p.E167K	LHFPL3_uc003vcf.2_Missense_Mutation_p.E167K	NM_199000	NP_945351	Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	153						integral to membrane					0						GGACTCAGATGAAGTAAAACG	0.443													5	33					0	0	0	0	A	104377175	A	A	104377175	3	1	272	1	0	0	0	0	1	0	0	0	8807	1291	45	2	505	2	LHFPL3	7	104377175	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	3893203	104377175	54761488	74	49318											
MKRN1	23608	broad.mit.edu	37	chr7	140154936	140154936	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cactttctgtctctgtggctCctctctacggccatcagggt	4	14	9	14	1	4	0	1	0	3	0	7	0	5	0	2	3	1	1	2	3	1	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:140154936C>G	uc003vvt.2	-	7	1420	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q	MKRN1_uc003vvs.2_Missense_Mutation_p.E335Q|MKRN1_uc011krd.1_Missense_Mutation_p.E133Q	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	399							ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					CTCTGTGGCTCCTCTCTACGG	0.488													12	158					0	0	0	0	G	140154936	G	G	140154936	3	3	272	1	0	0	0	0	1	0	0	0	9659	864	30	2	261	2	MKRN1	7	140154936	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	35777761	140154936	18983727	75	49319											
INTS10	55174	broad.mit.edu	37	chr8	19683985	19683985	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggttcttcttgaagatgtatCgaatgtgtatggtgatgtag	9	16	13	3	1	2	3	0	2	2	1	3	4	2	3	0	2	0	4	0	2	5	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr8:19683985C>T	uc003wzj.2	+	9	1186	c.1055C>T	c.(1054-1056)TCG>TTG	p.S352L		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	352					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		GAAGATGTATCGAATGTGTAT	0.398													13	101					0	0	0	0	T	19683985	T	T	19683985	3	4	272	1	0	0	0	0	1	0	0	0	7815	893	31	1	1089	1	INTS10	8	19683985	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08		19683985	126680037	76	49320											
NRG1	3084	broad.mit.edu	37	chr8	32621346	32621346	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcccccaaatcgcccccttCggaaatgtctccacccgtgt	7	9	6	19	3	1	0	0	0	1	0	5	1	2	1	6	1	0	0	6	1	2	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr8:32621346C>T	uc003xiv.2	+	12	1866	c.1349C>T	c.(1348-1350)TCG>TTG	p.S450L	NRG1_uc010lvo.2_3'UTR|NRG1_uc003xiu.2_Missense_Mutation_p.S455L|NRG1_uc003xiw.2_Missense_Mutation_p.S447L|NRG1_uc003xit.2_3'UTR|NRG1_uc010lvr.2_Missense_Mutation_p.S192L|NRG1_uc010lvs.2_Missense_Mutation_p.S192L|NRG1_uc010lvp.2_Missense_Mutation_p.S404L|NRG1_uc010lvq.2_Missense_Mutation_p.S387L|NRG1_uc011lbg.1_3'UTR|NRG1_uc011lbh.1_Missense_Mutation_p.S293L|NRG1_uc003xja.2_Missense_Mutation_p.S261L	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	450	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TCGCCCCCTTCGGAAATGTCT	0.562													11	124					0	0	0	0	T	32621346	T	T	32621346	3	4	272	1	0	0	0	0	1	0	0	0	10701	893	31	1	3120	1	NRG1	8	32621346	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	12937361	32621346	113742676	77	49321											
FAM135B	51059	broad.mit.edu	37	chr8	139164247	139164247	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaccaggggatggtctgctCcagcatctgttccagagtca	8	9	11	13	0	3	1	1	0	2	1	5	2	5	2	4	3	2	3	4	3	0	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr8:139164247C>A	uc003yuy.2	-	13	2642	c.2471G>T	c.(2470-2472)GGA>GTA	p.G824V	FAM135B_uc003yux.2_Missense_Mutation_p.G725V|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.G386V|FAM135B_uc003yvb.2_Missense_Mutation_p.G386V	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	824										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATGGTCTGCTCCAGCATCTGT	0.507										HNSCC(54;0.14)			7	76					1.12685e-05	5.36381e-05	1	0	A	139164247	A	A	139164247	3	1	272	1	0	0	0	0	1	0	0	0	5477	855	30	2	1781	2	FAM135B	8	139164247	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	106542901	139164247	7199775	78	49322											
TAF1L	138474	broad.mit.edu	37	chr9	32632475	32632475	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgggacaactttttaatctCttcctcaggcacaccaaatt	11	12	6	12	1	2	0	1	0	1	0	4	1	3	1	2	2	1	1	2	2	3	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:32632475C>T	uc003zrg.1	-	1	3193	c.3103G>A	c.(3103-3105)GAG>AAG	p.E1035K	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1035					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTTTTAATCTCTTCCTCAGGC	0.488													22	234					0	0	0	0	T	32632475	T	T	32632475	3	4	272	1	0	0	0	0	1	0	0	0	15589	922	32	2	2381	2	TAF1L	9	32632475	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08		32632475	108580956	79	49323											
TGFBR1	7046	broad.mit.edu	37	chr9	101910003	101910003	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacccatcagttgaagaaatGagaaaagttgtttgtgaaca	16	10	10	5	0	1	4	1	3	0	2	1	6	1	4	1	0	1	3	1	0	5	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:101910003G>C	uc004azc.2	+	8	1399	c.1323G>C	c.(1321-1323)ATG>ATC	p.M441I	TGFBR1_uc004azd.2_Missense_Mutation_p.M364I|TGFBR1_uc011lvc.1_Missense_Mutation_p.M372I	NM_004612	NP_004603	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor I	441	Protein kinase.|Cytoplasmic (Potential).				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)				TTGAAGAAATGAGAAAAGTTG	0.323													7	55					0	0	0	0	C	101910003	C	C	101910003	3	2	272	1	0	0	0	0	1	0	0	0	15887	1290	45	2	1353	2	TGFBR1	9	101910003	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	69277528	101910003	39303428	80	49324											
IKBKAP	8518	broad.mit.edu	37	chr9	111670656	111670656	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacccacagctcccagtttCactgtagggtcagcacttgg	8	9	9	15	0	2	0	2	0	0	0	3	0	3	0	3	2	2	4	3	2	1	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:111670656C>T	uc004bdm.3	-	13	1909	c.1389G>A	c.(1387-1389)GTG>GTA	p.V463V	IKBKAP_uc004bdl.2_Silent_p.V114V|IKBKAP_uc011lwc.1_Silent_p.V349V|IKBKAP_uc010mtq.2_Silent_p.V114V	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	463					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						CTCCCAGTTTCACTGTAGGGT	0.388													4	45					0	0	0	0	T	111670656	T	T	111670656	2	4	272	1	0	0	0	0	0	0	0	1	7649	813	29	2		2	IKBKAP	9	111670656	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	9760653	111670656	29542775	81	49325											
TNFSF8	944	broad.mit.edu	37	chr9	117692466	117692466	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagagtggctgtggtcaaatAgaaatagctgcggctcgtgg	10	9	15	7	2	1	2	1	0	0	2	2	2	1	2	0	4	2	3	0	4	4	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:117692466A>G	uc004bji.1	-	1	305	c.118T>C	c.(118-120)TAT>CAT	p.Y40H		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	40	Helical; Signal-anchor for type II membrane protein; (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						GTGGTCAAATAGAAATAGCTG	0.597													13	114					0	0	0	0	G	117692466	G	G	117692466	3	3	272	1	0	0	0	0	1	0	0	0	16377	420	15	5	602	5	TNFSF8	9	117692466	Missense_Mutation	SNP	A	TCGA-CX-7085-01A-21D-2012-08	6021810	117692466	23520965	82	49326											
METTL11A	28989	broad.mit.edu	37	chr9	132397708	132397708	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcaggagaacctccccgatGagatctaccatgtctatagc	11	8	10	12	1	2	2	0	1	2	2	3	5	3	2	4	2	3	1	4	2	4	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:132397708G>C	uc004byd.1	+	4	831	c.637G>C	c.(637-639)GAG>CAG	p.E213Q	METTL11A_uc010myw.1_RNA|METTL11A_uc011mbs.1_3'UTR|ASB6_uc004bye.1_3'UTR|ASB6_uc004byf.1_3'UTR|ASB6_uc004byg.1_3'UTR|ASB6_uc011mbt.1_3'UTR|ASB6_uc010myx.1_3'UTR	NM_014064	NP_054783	Q9BV86	NTM1A_HUMAN	methyltransferase like 11A	213					chromosome segregation|N-terminal peptidyl-proline dimethylation|N-terminal peptidyl-serine dimethylation|N-terminal peptidyl-serine trimethylation|spindle organization	nucleus	protein binding|protein methyltransferase activity				0						CCTCCCCGATGAGATCTACCA	0.627													7	119					0	0	0	0	C	132397708	C	C	132397708	3	2	272	1	0	0	0	0	1	0	0	0	9548	1291	45	2	647	2	METTL11A	9	132397708	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	14705242	132397708	8815723	83	49327											
GPR107	57720	broad.mit.edu	37	chr9	132854657	132854657	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gattcatatccttcgaaaacGacggtaaactatttctccct	12	13	5	11	3	2	0	1	0	1	0	5	3	3	0	2	1	2	1	2	1	6	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:132854657G>A	uc004bze.2	+	9	1087	c.860G>A	c.(859-861)CGA>CAA	p.R287Q	GPR107_uc004bzb.2_Missense_Mutation_p.R98Q|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.R287Q|GPR107_uc004bzd.2_Missense_Mutation_p.R287Q	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	287						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				CTTCGAAAACGACGGTAAACT	0.418													6	71					0	0	0	0	A	132854657	A	A	132854657	3	1	272	1	0	0	0	0	1	0	0	0	6661	1058	37	1	894	1	GPR107	9	132854657	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	456949	132854657	8358774	84	49328											
GTF3C4	9329	broad.mit.edu	37	chr9	135554308	135554308	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccatgactgcagacaaacaGaatggaacagtctatacttg	15	9	8	9	0	1	3	0	1	1	2	2	4	2	4	1	1	4	1	1	1	5	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:135554308G>C	uc010mzv.2	+	2	1560	c.1302G>C	c.(1300-1302)CAG>CAC	p.Q434H	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	434					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		CAGACAAACAGAATGGAACAG	0.453													4	102					0	0	0	0	C	135554308	C	C	135554308	3	2	272	1	0	0	0	0	1	0	0	0	6914	933	33	2	1308	2	GTF3C4	9	135554308	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	2699651	135554308	5659123	85	49329											
NOTCH1	4851	broad.mit.edu	37	chr9	139412282	139412282	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcacgggttcgagacgcactCgttgacgtcgatctcgcatc	7	9	12	13	7	1	2	0	1	1	1	6	4	1	2	0	1	0	5	0	1	0	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:139412282C>T	uc004chz.2	-	8	1363	c.1363G>A	c.(1363-1365)GAG>AAG	p.E455K		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	455	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GAGACGCACTCGTTGACGTCG	0.667			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			15	51					0	0	0	0	T	139412282	T	T	139412282	3	4	272	1	0	0	0	0	1	0	0	0	10601	893	31	1	6412	1	NOTCH1	9	139412282	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	3857974	139412282	1801149	86	49330											
CACNB2	783	broad.mit.edu	37	chr10	18827254	18827254	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagccgtacattagccacttCaagtctgcctcttagcccca	9	11	6	15	1	3	0	1	0	2	0	3	0	3	0	5	0	5	1	5	0	5	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:18827254C>G	uc001ipr.2	+	13	1508	c.1448C>G	c.(1447-1449)TCA>TGA	p.S483*	CACNB2_uc009xjz.1_Nonsense_Mutation_p.S233*|CACNB2_uc001ips.2_Nonsense_Mutation_p.S459*|CACNB2_uc001ipt.2_Nonsense_Mutation_p.S445*|CACNB2_uc001ipu.2_Nonsense_Mutation_p.S455*|CACNB2_uc001ipv.2_Nonsense_Mutation_p.S431*|CACNB2_uc009xka.1_Nonsense_Mutation_p.S417*|CACNB2_uc001ipw.2_Nonsense_Mutation_p.S390*|CACNB2_uc001ipx.2_Nonsense_Mutation_p.S428*|CACNB2_uc001ipz.2_Nonsense_Mutation_p.S405*|CACNB2_uc001ipy.2_Nonsense_Mutation_p.S429*|CACNB2_uc010qco.1_Nonsense_Mutation_p.S397*|CACNB2_uc001iqa.2_Nonsense_Mutation_p.S435*|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	483					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTAGCCACTTCAAGTCTGCCT	0.478													9	266					0	0	0	0	G	18827254	G	G	18827254	4	3	272	1	0	0	0	0	0	1	0	0	2565	838	29	2	1808	2	CACNB2	10	18827254	Nonsense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08		18827254	116707493	87	49331											
GPR158	57512	broad.mit.edu	37	chr10	25887142	25887142	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aactaacacaaaaactaaaaGaagacagcgaggctgagtcc	20	4	8	9	1	0	3	0	1	0	2	1	4	1	3	1	1	4	1	1	1	7	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:25887142G>C	uc001isj.2	+	11	2647	c.2587G>C	c.(2587-2589)GAA>CAA	p.E863Q	GPR158_uc001isk.2_Missense_Mutation_p.E238Q	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	863	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AAAACTAAAAGAAGACAGCGA	0.507													5	144					0	0	0	0	C	25887142	C	C	25887142	3	2	272	1	0	0	0	0	1	0	0	0	6701	943	33	2	2629	2	GPR158	10	25887142	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	7059888	25887142	109647605	88	49332											
ARMC4	55130	broad.mit.edu	37	chr10	28229719	28229719	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgtggaatcatgtgcacAgtctagtagagcaacctata	12	13	9	7	0	2	1	1	0	1	1	2	2	2	2	1	1	3	3	1	1	6	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:28229719A>T	uc009xky.2	-	13	1857	c.1759T>A	c.(1759-1761)TGT>AGT	p.C587S	ARMC4_uc010qds.1_Missense_Mutation_p.C112S|ARMC4_uc010qdt.1_Missense_Mutation_p.C279S|ARMC4_uc001itz.2_Missense_Mutation_p.C587S|ARMC4_uc010qdu.1_Missense_Mutation_p.C279S	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	587							binding			ovary(4)|skin(2)	6						TCATGTGCACAGTCTAGTAGA	0.443													6	66					0	0	0	0	T	28229719	T	T	28229719	3	4	272	1	0	0	0	0	1	0	0	0	955	188	7	5	1407	5	ARMC4	10	28229719	Missense_Mutation	SNP	A	TCGA-CX-7085-01A-21D-2012-08	2342577	28229719	107305028	89	49333											
NRP1	8829	broad.mit.edu	37	chr10	33502550	33502550	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggttaccaggcggatgttttCaggcatccagtttctgtccc	6	13	11	11	1	2	0	1	0	1	0	4	1	4	1	3	4	1	4	3	4	1	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:33502550C>G	uc001iwx.3	-	9	1901	c.1378G>C	c.(1378-1380)GAA>CAA	p.E460Q	NRP1_uc001iwv.3_Missense_Mutation_p.E460Q|NRP1_uc009xlz.2_Missense_Mutation_p.E460Q|NRP1_uc001iww.3_Missense_Mutation_p.E279Q|NRP1_uc001iwy.3_Missense_Mutation_p.E460Q|NRP1_uc001iwz.2_Missense_Mutation_p.E460Q|NRP1_uc001ixa.2_Missense_Mutation_p.E460Q|NRP1_uc001ixb.1_Missense_Mutation_p.E460Q|NRP1_uc001ixc.1_Missense_Mutation_p.E460Q	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	460	Extracellular (Potential).|F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	CGGATGTTTTCAGGCATCCAG	0.517													11	136					0	0	0	0	G	33502550	G	G	33502550	3	3	272	1	0	0	0	0	1	0	0	0	10714	835	29	2	1440	2	NRP1	10	33502550	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	5272831	33502550	102032197	90	49334											
RHOBTB1	9886	broad.mit.edu	37	chr10	62631978	62631978	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgatttccttacggaacttgGagcatacactgttgtagttg	9	15	10	7	1	0	1	0	1	0	0	1	3	1	3	1	2	4	4	1	2	4	7	rs148172627		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:62631978G>C	uc001jli.2	-	11	2324	c.1886C>G	c.(1885-1887)TCC>TGC	p.S629C	RHOBTB1_uc001jlh.2_Missense_Mutation_p.S629C|RHOBTB1_uc001jlj.2_Missense_Mutation_p.S629C|RHOBTB1_uc001jlk.2_Missense_Mutation_p.S629C|RHOBTB1_uc009xpe.1_Missense_Mutation_p.S567C|RHOBTB1_uc009xpd.2_Intron|RHOBTB1_uc001jll.2_Missense_Mutation_p.S379C	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	629					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					ACGGAACTTGGAGCATACACT	0.483													5	115					0	0	0	0	C	62631978	C	C	62631978	3	2	272	1	0	0	0	0	1	0	0	0	13398	1174	41	2	212	2	RHOBTB1	10	62631978	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	29129428	62631978	72902769	91	49335											
RUFY2	55680	broad.mit.edu	37	chr10	70156542	70156542	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttaatagtactaacctcaaGagatccctctgaataattaa	16	12	4	9	0	2	2	1	1	1	1	3	3	3	2	2	0	2	1	2	0	8	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:70156542G>A	uc001job.2	-	4	825	c.498C>T	c.(496-498)CTC>CTT	p.L166L	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Intron|RUFY2_uc010qiw.1_Silent_p.L73L|RUFY2_uc001jod.1_Silent_p.L131L|RUFY2_uc009xpv.1_Silent_p.L14L|RUFY2_uc001joe.1_Silent_p.L131L	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	180	RUN.					nucleus	metal ion binding			ovary(1)	1						CTAACCTCAAGAGATCCCTCT	0.353													6	41					0	0	0	0	A	70156542	A	A	70156542	2	1	272	1	0	0	0	0	0	0	0	1	13804	929	33	2		2	RUFY2	10	70156542	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	7524564	70156542	65378205	92	49336											
VCL	7414	broad.mit.edu	37	chr10	75855416	75855416	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttttctcttggtccaggtCaggctgccatccgggggctt	3	14	13	11	1	2	0	1	0	1	0	5	0	4	0	3	5	1	3	3	5	0	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:75855416C>G	uc001jwd.2	+	12	1640	c.1546C>G	c.(1546-1548)CAG>GAG	p.Q516E	VCL_uc009xrr.2_Missense_Mutation_p.Q265E|VCL_uc010qky.1_Missense_Mutation_p.Q423E|VCL_uc001jwe.2_Missense_Mutation_p.Q516E|VCL_uc010qkz.1_Intron	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	516	N-terminal globular head.|3.|3 X 112 AA tandem repeats.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					TGGTCCAGGTCAGGCTGCCAT	0.478													4	88					0	0	0	0	G	75855416	G	G	75855416	3	3	272	1	0	0	0	0	1	0	0	0	17207	827	29	2	1592	2	VCL	10	75855416	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	5698874	75855416	59679331	93	49337											
LGI1	9211	broad.mit.edu	37	chr10	95556810	95556810	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtttggtggctctcacatCtataagcgagacagttttgc	8	14	10	9	1	2	1	1	0	2	1	3	2	2	1	0	2	2	3	0	2	2	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:95556810C>G	uc001kjc.3	+	8	1260	c.924C>G	c.(922-924)ATC>ATG	p.I308M	LGI1_uc010qnv.1_Missense_Mutation_p.I260M|LGI1_uc001kjd.3_Intron|LGI1_uc009xui.2_RNA|LGI1_uc001kje.2_Intron	NM_005097	NP_005088	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1 precursor	308	EAR 2.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4		Colorectal(252;0.124)				GCTCTCACATCTATAAGCGAG	0.373													4	77					0	0	0	0	G	95556810	G	G	95556810	3	3	272	1	0	0	0	0	1	0	0	0	8792	903	32	2	954	2	LGI1	10	95556810	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	19701394	95556810	39977937	94	49338											
PDCD11	22984	broad.mit.edu	37	chr10	105203734	105203734	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggagaaagctgtgtggatCaaatacggcgccttccttct	10	10	11	10	2	2	1	1	0	1	1	3	3	3	2	2	3	2	1	2	3	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:105203734C>G	uc001kwy.1	+	34	5274	c.5187C>G	c.(5185-5187)ATC>ATG	p.I1729M		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1729	HAT 2.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CTGTGTGGATCAAATACGGCG	0.597													9	94					0	0	0	0	G	105203734	G	G	105203734	3	3	272	1	0	0	0	0	1	0	0	0	11671	816	29	2	5317	2	PDCD11	10	105203734	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	9646924	105203734	30331013	95	49339											
ACSL5	51703	broad.mit.edu	37	chr10	114169340	114169340	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaatgtagagaaaggcttcaCcccgagcctgaaggtgatca	13	7	12	9	1	2	3	2	2	0	1	2	6	2	3	3	2	1	2	3	2	4	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:114169340C>T	uc001kzs.2	+	7	749	c.608C>T	c.(607-609)ACC>ATC	p.T203I	ACSL5_uc001kzt.2_Missense_Mutation_p.T203I|ACSL5_uc001kzu.2_Missense_Mutation_p.T259I|ACSL5_uc009xxz.2_Missense_Mutation_p.T203I|ACSL5_uc010qrj.1_5'UTR	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	203	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		AAAGGCTTCACCCCGAGCCTG	0.478													16	118					0	0	0	0	T	114169340	T	T	114169340	3	4	272	1	0	0	0	0	1	0	0	0	180	507	18	4	802	4	ACSL5	10	114169340	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	8965606	114169340	21365407	96	49340											
PRLHR	2834	broad.mit.edu	37	chr10	120353832	120353832	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagcccaaaggcgtaagggtCgatggcgtgggggtcgaggt	8	6	19	8	4	0	0	0	0	0	0	2	2	0	0	1	6	1	1	1	6	2	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:120353832C>T	uc001ldp.1	-	2	1064	c.925G>A	c.(925-927)GAC>AAC	p.D309N		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	309	Extracellular (Potential).				female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GCGTAAGGGTCGATGGCGTGG	0.632													5	69					0	0	0	0	T	120353832	T	T	120353832	3	4	272	1	0	0	0	0	1	0	0	0	12592	884	31	1	191	1	PRLHR	10	120353832	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	6184492	120353832	15180915	97	49341											
GRK5	2869	broad.mit.edu	37	chr10	121207689	121207689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaggaggagggggctgcaGaggtcaagagacaccccttc	10	4	16	11	0	1	2	1	0	0	2	2	5	1	4	3	5	1	2	3	5	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:121207689G>A	uc001led.2	+	13	1554	c.1321G>A	c.(1321-1323)GAG>AAG	p.E441K	GRK5_uc009xzh.2_Missense_Mutation_p.E306K	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	441	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GGGGGCTGCAGAGGTCAAGAG	0.597													21	116					0	0	0	0	A	121207689	A	A	121207689	3	1	272	1	0	0	0	0	1	0	0	0	6831	943	33	2	1371	2	GRK5	10	121207689	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	853857	121207689	14327058	98	49342											
OR51G2	81282	broad.mit.edu	37	chr11	4936270	4936270	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctatacccactgtagagacGatgacaaacatgccgtagat	14	9	8	10	2	1	3	0	1	1	2	1	5	1	3	2	0	3	2	2	0	5	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:4936270G>A	uc001lzr.1	-	1	624	c.624C>T	c.(622-624)ATC>ATT	p.I208I		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTAGAGACGATGACAAACA	0.512													4	33					0	0	0	0	A	4936270	A	A	4936270	2	1	272	1	0	0	0	0	0	0	0	1	11153	1048	37	1		1	OR51G2	11	4936270	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08		4936270	130070246	99	49343											
CYP2R1	120227	broad.mit.edu	37	chr11	14899669	14899669	+	Nonstop_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaaacatcccaggcagtttCagcgtctttcagcacagatg	12	9	9	11	1	3	1	2	0	1	1	4	2	4	1	1	1	3	3	1	1	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:14899669C>A	uc001mlr.2	-	5	1505	c.1505G>T	c.(1504-1506)TGA>TTA	p.*502L	CYP2R1_uc001mlo.2_Nonstop_Mutation_p.*269L|CYP2R1_uc001mlp.2_Nonstop_Mutation_p.*385L|CYP2R1_uc001mlq.2_RNA	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	502					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	CAGGCAGTTTCAGCGTCTTTC	0.418													9	89					0.000442599	0.00205539	1	0	A	14899669	A	A	14899669	4	1	272	1	0	0	0	0	0	0	0	0	4190	837	29	2	4	2	CYP2R1	11	14899669	Nonstop_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	9963399	14899669	120106847	100	49344											
CYP2R1	120227	broad.mit.edu	37	chr11	14900748	14900748	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggaacacttctgggtctctCcagtacttttcatcaaagtg	9	14	8	10	0	4	0	2	0	2	0	6	1	5	1	1	2	2	1	1	2	3	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:14900748C>A	uc001mlr.2	-	4	1242	c.1242G>T	c.(1240-1242)TGG>TGT	p.W414C	CYP2R1_uc001mlo.2_Missense_Mutation_p.W181C|CYP2R1_uc001mlp.2_Missense_Mutation_p.W297C|CYP2R1_uc001mlq.2_RNA	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	414					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	CTGGGTCTCTCCAGTACTTTT	0.408													5	53					0.000602214	0.00278305	1	0	A	14900748	A	A	14900748	3	1	272	1	0	0	0	0	1	0	0	0	4190	856	30	2	271	2	CYP2R1	11	14900748	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	1079	14900748	120105768	101	49345											
OR5AR1	219493	broad.mit.edu	37	chr11	56431616	56431616	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctgggctcttacctggctgGtctagtgagtttagtagccc	5	13	13	10	0	2	1	0	1	2	0	2	1	2	1	2	3	2	5	2	3	4	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:56431616G>A	uc010rjm.1	+	1	455	c.455G>A	c.(454-456)GGT>GAT	p.G152D		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TACCTGGCTGGTCTAGTGAGT	0.502													13	161					0	0	0	0	A	56431616	A	A	56431616	3	1	272	1	0	0	0	0	1	0	0	0	11199	1261	44	4	457	4	OR5AR1	11	56431616	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	41530868	56431616	78574900	102	49346											
CTNND1	1500	broad.mit.edu	37	chr11	57578934	57578934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgatgatagtactctccctCtcattgaccggaaccaaaaa	14	10	6	11	1	2	3	1	3	2	0	4	4	2	4	3	1	2	1	3	1	5	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:57578934C>T	uc001nmc.3	+	17	3185	c.2614C>T	c.(2614-2616)CTC>TTC	p.L872F	CTNND1_uc001nlh.1_Missense_Mutation_p.L872F|CTNND1_uc001nlu.3_Missense_Mutation_p.L765F|CTNND1_uc001nlt.3_Missense_Mutation_p.L765F|CTNND1_uc001nls.3_Missense_Mutation_p.L765F|CTNND1_uc001nlw.3_Missense_Mutation_p.L765F|CTNND1_uc001nmf.3_Missense_Mutation_p.L872F|CTNND1_uc001nmd.3_Missense_Mutation_p.L818F|CTNND1_uc001nlk.3_Missense_Mutation_p.L818F|CTNND1_uc001nme.3_Missense_Mutation_p.L866F|CTNND1_uc001nll.3_Missense_Mutation_p.L812F|CTNND1_uc001nmg.3_Missense_Mutation_p.L812F|CTNND1_uc001nlj.3_Missense_Mutation_p.L812F|CTNND1_uc001nlr.3_Missense_Mutation_p.L812F|CTNND1_uc001nlp.3_Missense_Mutation_p.L812F|CTNND1_uc001nlx.3_Missense_Mutation_p.L549F|CTNND1_uc001nlz.3_Missense_Mutation_p.L549F|CTNND1_uc009ymn.2_Missense_Mutation_p.L543F|CTNND1_uc001nlm.3_Missense_Mutation_p.L866F|CTNND1_uc001nly.3_Missense_Mutation_p.L543F|CTNND1_uc001nmb.3_Missense_Mutation_p.L543F|CTNND1_uc001nma.3_Missense_Mutation_p.L543F|CTNND1_uc001nmi.3_Missense_Mutation_p.L771F|CTNND1_uc001nmh.3_Missense_Mutation_p.L866F|CTNND1_uc001nlq.3_Missense_Mutation_p.L771F|CTNND1_uc001nln.3_Missense_Mutation_p.L866F|CTNND1_uc001nli.3_Missense_Mutation_p.L866F|CTNND1_uc001nlo.3_Missense_Mutation_p.L765F|CTNND1_uc001nlv.3_Missense_Mutation_p.L765F	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	872					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				TACTCTCCCTCTCATTGACCG	0.438													8	158					0	0	0	0	T	57578934	T	T	57578934	3	4	272	1	0	0	0	0	1	0	0	0	4036	913	32	2	2672	2	CTNND1	11	57578934	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	1147318	57578934	77427582	103	49347											
C11orf9	745	broad.mit.edu	37	chr11	61551813	61551813	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caaaggaggaaccatgtgagGaggggagccttccacagagt	13	5	15	8	0	0	2	0	1	0	1	1	6	1	6	3	5	2	0	3	5	2	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:61551813G>C	uc001nsc.1	+	25	3352	c.3256G>C	c.(3256-3258)GAG>CAG	p.E1086Q	C11orf9_uc001nse.1_Missense_Mutation_p.E1046Q|C11orf9_uc010rll.1_Missense_Mutation_p.E472Q	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	1086					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						ACCATGTGAGGAGGGGAGCCT	0.622													4	50					0	0	0	0	C	61551813	C	C	61551813	3	2	272	1	0	0	0	0	1	0	0	0	1677	1175	41	2	3380	2	C11orf9	11	61551813	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	3972879	61551813	73454703	104	49348											
CD248	57124	broad.mit.edu	37	chr11	66083138	66083138	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagtgtgggatgcgtggcaGagaccaccacaggccgggtg	8	5	18	10	2	0	1	0	0	0	1	0	3	0	2	3	4	1	2	3	4	0	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:66083138G>C	uc001ohm.1	-	1	1378	c.1361C>G	c.(1360-1362)TCT>TGT	p.S454C		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	454	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	ATGCGTGGCAGAGACCACCAC	0.667													7	106					0	0	0	0	C	66083138	C	C	66083138	3	2	272	1	0	0	0	0	1	0	0	0	3004	942	33	2	916	2	CD248	11	66083138	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	4531325	66083138	68923378	105	49349											
RSF1	51773	broad.mit.edu	37	chr11	77412118	77412118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggttatctctgtattttctGaggcagtggtttcttcttca	6	19	9	7	0	5	1	1	1	4	0	6	1	5	1	0	3	0	4	0	3	2	7			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:77412118G>A	uc001oyn.2	-	6	2276	c.2156C>T	c.(2155-2157)TCA>TTA	p.S719L	RSF1_uc001oym.2_Missense_Mutation_p.S467L	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	719					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			TGTATTTTCTGAGGCAGTGGT	0.428													6	110					0	0	0	0	A	77412118	A	A	77412118	3	1	272	1	0	0	0	0	1	0	0	0	13764	1294	45	2	2213	2	RSF1	11	77412118	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	11328980	77412118	57594398	106	49350											
RSF1	51773	broad.mit.edu	37	chr11	77412372	77412372	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtttctcacagtggtcaatGatattagatggtggagaagt	12	13	12	4	0	2	3	2	1	1	2	3	4	2	3	0	3	0	1	0	3	4	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:77412372G>C	uc001oyn.2	-	6	2022	c.1902C>G	c.(1900-1902)ATC>ATG	p.I634M	RSF1_uc001oym.2_Missense_Mutation_p.I382M	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	634					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			AGTGGTCAATGATATTAGATG	0.428													8	106					0	0	0	0	C	77412372	C	C	77412372	3	2	272	1	0	0	0	0	1	0	0	0	13764	1280	45	2	2467	2	RSF1	11	77412372	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	254	77412372	57594144	107	49351											
MMP12	4321	broad.mit.edu	37	chr11	102734890	102734890	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacttactgtttttagagtaGaagactgcatcaattttagg	12	16	8	5	0	1	3	1	0	0	3	1	3	1	3	0	1	3	3	0	1	7	8			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:102734890G>C	uc001phk.2	-	10	1344	c.1299C>G	c.(1297-1299)TTC>TTG	p.F433L		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	433	Hemopexin-like 4.				positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TTTTAGAGTAGAAGACTGCAT	0.383													3	38					0	0	0	0	C	102734890	C	C	102734890	3	2	272	1	0	0	0	0	1	0	0	0	9704	933	33	2	121	2	MMP12	11	102734890	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	25322518	102734890	32271626	108	49352											
MLL	4297	broad.mit.edu	37	chr11	118374023	118374023	+	Missense_Mutation	SNP	G	C	C																															gagtttatggatgaggttttGactcctgagtatatgggcca																										TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:118374023G>C	uc001pta.2	+	27	7430	c.7407G>C	c.(7405-7407)TTG>TTC	p.L2469F	MLL_uc001ptb.2_Missense_Mutation_p.L2472F	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2469					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		ATGAGGTTTTGACTCCTGAGT	0.433			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								5	68					0	0	0	0	C	118374023	C	C	118374023	3	2	272	1	0	0	0	0	1	0	0	0	9673	1281	45	2	7513	2	MLL	11	118374023	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	15639133	118374023	16632493	109	49353	110	2									
MLL	4297	broad.mit.edu	37	chr11	118374030	118374030	+	Missense_Mutation	SNP	G	A	A																															tggatgaggttttgactcctGagtatatgggccaacgacca																										TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:118374030G>A	uc001pta.2	+	27	7437	c.7414G>A	c.(7414-7416)GAG>AAG	p.E2472K	MLL_uc001ptb.2_Missense_Mutation_p.E2475K	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2472					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TTTGACTCCTGAGTATATGGG	0.438			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								5	67					0	0	0	0	A	118374030	A	A	118374030	3	1	272	1	0	0	0	0	1	0	0	0	9673	1291	45	2	7520	2	MLL	11	118374030	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	7	118374030	16632486	110	49354	110	2									
OR8G2	26492	broad.mit.edu	37	chr11	124095773	124095773	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttgctattgcagagtgtCacatgttggctgtaacggca	8	15	11	7	1	1	1	1	0	0	1	1	1	1	1	0	2	3	6	0	2	2	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:124095773C>T	uc010saf.1	+	1	376	c.376C>T	c.(376-378)CAC>TAC	p.H126Y		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	126						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TGCAGAGTGTCACATGTTGGC	0.458													18	198					0	0	0	0	T	124095773	T	T	124095773	3	4	272	1	0	0	0	0	1	0	0	0	11289	826	29	2	378	2	OR8G2	11	124095773	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	5721743	124095773	10910743	111	49355											
SLCO1C1	53919	broad.mit.edu	37	chr12	20876121	20876121	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattctctgttcggcatggtGacgtacaaaccaaagtacat	13	11	8	9	2	1	1	0	1	1	0	3	1	1	1	1	2	3	4	1	2	5	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:20876121G>A	uc001rej.3	+	10	1474	c.1119G>A	c.(1117-1119)GTG>GTA	p.V373V	SLCO1C1_uc010sii.1_Silent_p.V373V|SLCO1C1_uc010sij.1_Silent_p.V324V|SLCO1C1_uc009zip.2_Silent_p.V207V|SLCO1C1_uc001rei.2_Silent_p.V373V|SLCO1C1_uc010sik.1_Silent_p.V255V	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	373	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TCGGCATGGTGACGTACAAAC	0.423													7	81					0	0	0	0	A	20876121	A	A	20876121	2	1	272	1	0	0	0	0	0	0	0	1	14789	1277	45	2		2	SLCO1C1	12	20876121	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08		20876121	112975774	112	49356											
C12orf35	55196	broad.mit.edu	37	chr12	32135621	32135621	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaatataaatcaaaaattCaaaatgaaaatatgctactt	22	11	4	4	0	2	1	2	1	0	0	2	2	2	2	0	1	2	1	0	1	12	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:32135621C>G	uc001rks.2	+	4	2146	c.1732C>G	c.(1732-1734)CAA>GAA	p.Q578E		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	578										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			ATCAAAAATTCAAAATGAAAA	0.348													5	31					0	0	0	0	G	32135621	G	G	32135621	3	3	272	1	0	0	0	0	1	0	0	0	1688	827	29	2	1734	2	C12orf35	12	32135621	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	11259500	32135621	101716274	113	49357											
NCKAP1L	3071	broad.mit.edu	37	chr12	54910753	54910753	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagactgtgttggctgatGaaccgggactactgggtcct	7	11	15	8	1	0	3	0	2	0	1	1	5	1	4	2	4	2	2	2	4	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:54910753G>A	uc001sgc.3	+	11	1151	c.1072G>A	c.(1072-1074)GAA>AAA	p.E358K	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.E308K	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	358					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GTTGGCTGATGAACCGGGACT	0.507													9	88					0	0	0	0	A	54910753	A	A	54910753	3	1	272	1	0	0	0	0	1	0	0	0	10276	1291	45	2	1114	2	NCKAP1L	12	54910753	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	22775132	54910753	78941142	114	49358											
TRHDE	29953	broad.mit.edu	37	chr12	72667122	72667122	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcacgcttcccgagtggcGgtggagaaagtgcagctggc	7	7	16	11	3	0	1	0	0	0	1	1	3	1	1	1	4	3	4	1	4	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:72667122G>A	uc001sxa.2	+	1	594	c.564G>A	c.(562-564)GCG>GCA	p.A188A	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	188	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CCCGAGTGGCGGTGGAGAAAG	0.627													10	65					0	0	0	0	A	72667122	A	A	72667122	2	1	272	1	0	0	0	0	0	0	0	1	16546	1103	39	1		1	TRHDE	12	72667122	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	17756369	72667122	61184773	115	49359											
SLC5A8	160728	broad.mit.edu	37	chr12	101555757	101555757	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtttagatagttacctgttGataaactgacaagtatcccc	12	14	7	8	0	0	3	0	2	0	1	1	3	1	3	3	0	2	4	3	0	7	7	rs142965122		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:101555757G>A	uc001thz.3	-	13	2015	c.1625C>T	c.(1624-1626)TCA>TTA	p.S542L		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	542	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						GTTACCTGTTGATAAACTGAC	0.313													6	178					0	0	0	0	A	101555757	A	A	101555757	3	1	272	1	0	0	0	0	1	0	0	0	14735	1294	45	2	219	2	SLC5A8	12	101555757	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	28888635	101555757	32296138	116	49360											
ASCL1	429	broad.mit.edu	37	chr12	103352547	103352547	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctgcagcagctgctggaCgagcatgacgcggtgagcgc	7	5	17	12	5	0	2	0	2	0	0	0	4	0	3	0	2	6	6	0	2	0	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:103352547C>T	uc001tjr.3	+	1	1096	c.525C>T	c.(523-525)GAC>GAT	p.D175D		NM_004316	NP_004307	P50553	ASCL1_HUMAN	achaete-scute complex homolog 1	175					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity				0						AGCTGCTGGACGAGCATGACG	0.662													11	45					0	0	0	0	T	103352547	T	T	103352547	2	4	272	1	0	0	0	0	0	0	0	1	1036	535	19	1		1	ASCL1	12	103352547	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	1796790	103352547	30499348	117	49361											
GCN1L1	10985	broad.mit.edu	37	chr12	120572483	120572483	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtcctgcagggctttggtGaaagtggtctgcagctgggg	6	10	18	7	0	1	1	0	1	1	0	2	2	2	1	1	5	3	4	1	5	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:120572483G>A	uc001txo.2	-	52	7069	c.7056C>T	c.(7054-7056)TTC>TTT	p.F2352F		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2352	HEAT 21.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGCTTTGGTGAAAGTGGTCT	0.582													8	69					0	0	0	0	A	120572483	A	A	120572483	2	1	272	1	0	0	0	0	0	0	0	1	6334	1281	45	2		2	GCN1L1	12	120572483	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	17219936	120572483	13279412	118	49362											
ACADS	35	broad.mit.edu	37	chr12	121164932	121164932	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatgccgggactttgccgaGaaggagttgtttcccattgc	8	11	12	10	2	0	1	0	0	0	1	1	4	1	3	3	2	3	2	3	2	1	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:121164932G>A	uc001tza.3	+	2	268	c.150G>A	c.(148-150)GAG>GAA	p.E50E	ACADS_uc010szl.1_Silent_p.E50E	NM_000017	NP_000008	P16219	ACADS_HUMAN	short-chain acyl-CoA dehydrogenase precursor	50						mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(2)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)	ACTTTGCCGAGAAGGAGTTGT	0.572													11	184					0	0	0	0	A	121164932	A	A	121164932	2	1	272	1	0	0	0	0	0	0	0	1	114	933	33	2		2	ACADS	12	121164932	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	592449	121164932	12686963	119	49363											
CPB2	1361	broad.mit.edu	37	chr13	46656636	46656636	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctcgggggctgactgtgtcGttggaaatctgctgttgaat	6	13	15	7	2	1	2	0	2	1	0	3	3	1	3	0	3	1	5	0	3	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr13:46656636G>A	uc001vaw.2	-	4	391	c.324C>T	c.(322-324)AAC>AAT	p.N108N	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Silent_p.N108N	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	108					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		TGACTGTGTCGTTGGAAATCT	0.453													7	109					0	0	0	0	A	46656636	A	A	46656636	2	1	272	1	0	0	0	0	0	0	0	1	3812	1136	40	1		1	CPB2	13	46656636	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08		46656636	68513242	120	49364											
RB1	5925	broad.mit.edu	37	chr13	49033886	49033886	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccttctgtctgagcacccaGaattagaacatatcatctgg	11	11	8	11	0	4	3	1	1	3	2	4	3	4	3	2	1	2	1	2	1	4	3	rs137853295		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr13:49033886G>C	uc001vcb.2	+	20	2189	c.2023G>C	c.(2023-2025)GAA>CAA	p.E675Q		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	675	Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGAGCACCCAGAATTAGAACA	0.423		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			6	87					0	0	0	0	C	49033886	C	C	49033886	3	2	272	1	0	0	0	0	1	0	0	0	13163	943	33	2	2101	2	RB1	13	49033886	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	2377250	49033886	66135992	121	49365											
OR4M1	441670	broad.mit.edu	37	chr14	20248859	20248859	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgaccgctatgctgctatCtgccgacccctccactatgc	7	11	7	16	2	1	1	0	1	1	0	2	2	2	1	5	0	4	3	5	0	4	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:20248859C>T	uc010tku.1	+	1	378	c.378C>T	c.(376-378)ATC>ATT	p.I126I		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATGCTGCTATCTGCCGACCCC	0.507													19	512					0	0	0	0	T	20248859	T	T	20248859	2	4	272	1	0	0	0	0	0	0	0	1	11129	903	32	2		2	OR4M1	14	20248859	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08		20248859	87100681	122	49366											
ARHGAP5	394	broad.mit.edu	37	chr14	32561983	32561983	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacattaattctggctaatcAgagagattccattagtaaga	15	13	7	6	0	2	3	1	0	1	3	3	4	3	3	1	1	1	2	1	1	5	7			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:32561983A>G	uc001wrl.2	+	2	2347	c.2108A>G	c.(2107-2109)CAG>CGG	p.Q703R	ARHGAP5_uc001wrm.2_Missense_Mutation_p.Q703R|ARHGAP5_uc001wrn.2_Missense_Mutation_p.Q703R|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	703					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CTGGCTAATCAGAGAGATTCC	0.373													4	49					0	0	0	0	G	32561983	G	G	32561983	3	3	272	1	0	0	0	0	1	0	0	0	886	188	7	5	2110	5	ARHGAP5	14	32561983	Missense_Mutation	SNP	A	TCGA-CX-7085-01A-21D-2012-08	12313124	32561983	74787557	123	49367											
MIPOL1	145282	broad.mit.edu	37	chr14	37777588	37777588	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actgaacagaataaacaatgCagacacagggatagctattc	18	7	8	8	0	0	3	0	1	0	2	1	4	0	4	0	1	4	2	0	1	7	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:37777588C>G	uc001wuc.2	+	10	1195	c.692C>G	c.(691-693)GCA>GGA	p.A231G	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Missense_Mutation_p.A200G|MIPOL1_uc001wud.2_Missense_Mutation_p.A231G|MIPOL1_uc010ams.2_Missense_Mutation_p.A231G|MIPOL1_uc001wue.2_Missense_Mutation_p.A200G|MIPOL1_uc010amt.2_Missense_Mutation_p.A50G	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	231										ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		ATAAACAATGCAGACACAGGG	0.313													5	128					0	0	0	0	G	37777588	G	G	37777588	3	3	272	1	0	0	0	0	1	0	0	0	9646	710	25	4	718	4	MIPOL1	14	37777588	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	5215605	37777588	69571952	124	49368											
ESR2	2100	broad.mit.edu	37	chr14	64716327	64716327	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgttggagttttaactctcGaaaccttgaagtagttgcca	10	14	10	7	1	1	1	0	1	1	0	2	3	1	2	2	1	3	4	2	1	4	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:64716327G>A	uc001xha.1	-	7	1630	c.1162C>T	c.(1162-1164)CGA>TGA	p.R388*	ESR2_uc001xgu.2_Nonsense_Mutation_p.R388*|ESR2_uc001xgv.2_Nonsense_Mutation_p.R388*|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Nonsense_Mutation_p.R388*|ESR2_uc001xgy.1_Nonsense_Mutation_p.R388*|ESR2_uc001xgz.1_Nonsense_Mutation_p.R388*|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Intron|ESR2_uc010aqd.1_Intron	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	388	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	TTTAACTCTCGAAACCTTGAA	0.423													10	62					0	0	0	0	A	64716327	A	A	64716327	4	1	272	1	0	0	0	0	0	1	0	0	5281	1066	37	1	528	1	ESR2	14	64716327	Nonsense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	26938739	64716327	42633213	125	49369											
SPTB	6710	broad.mit.edu	37	chr14	65234494	65234494	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtccactgtgtgtccaaagtCcccgctggccaggtagggct	6	9	13	13	1	0	0	0	0	0	0	3	0	3	0	5	3	0	3	5	3	2	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:65234494C>G	uc001xht.2	-	29	6160	c.6106G>C	c.(6106-6108)GAC>CAC	p.D2036H	SPTB_uc001xhr.2_Missense_Mutation_p.D2036H|SPTB_uc001xhs.2_Missense_Mutation_p.D2036H|SPTB_uc001xhu.2_Missense_Mutation_p.D2036H|SPTB_uc010aqi.2_Missense_Mutation_p.D697H	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	2036	Spectrin 17.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGTCCAAAGTCCCCGCTGGCC	0.617													4	74					0	0	0	0	G	65234494	G	G	65234494	3	3	272	1	0	0	0	0	1	0	0	0	15184	855	30	2	977	2	SPTB	14	65234494	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	518167	65234494	42115046	126	49370											
FLRT2	23768	broad.mit.edu	37	chr14	86088748	86088748	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgactcaaggggtttttgAtaatctctccaacctgaagc	10	12	9	10	0	2	3	1	3	1	0	4	3	3	3	2	2	2	2	2	2	4	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:86088748A>G	uc001xvr.2	+	2	1657	c.890A>G	c.(889-891)GAT>GGT	p.D297G	FLRT2_uc010atd.2_Missense_Mutation_p.D297G	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	297	Extracellular (Potential).|LRR 10.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GGGGTTTTTGATAATCTCTCC	0.443													21	234					0	0	0	0	G	86088748	G	G	86088748	3	3	272	1	0	0	0	0	1	0	0	0	5971	333	12	5	892	5	FLRT2	14	86088748	Missense_Mutation	SNP	A	TCGA-CX-7085-01A-21D-2012-08	20854254	86088748	21260792	127	49371											
TTBK2	146057	broad.mit.edu	37	chr15	43122171	43122171	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcaagaatcccacagaatGaatgctttcaatagactcca	16	9	6	10	0	1	4	1	1	0	3	3	4	3	4	2	0	2	2	2	0	6	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr15:43122171G>A	uc001zqo.2	-	5	836	c.397C>T	c.(397-399)CAT>TAT	p.H133Y	TTBK2_uc010bcy.2_Missense_Mutation_p.H64Y|TTBK2_uc001zqp.2_Missense_Mutation_p.H133Y|TTBK2_uc010bcz.1_Missense_Mutation_p.H133Y	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	133	Protein kinase.				cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CCCACAGAATGAATGCTTTCA	0.458													5	49					0	0	0	0	A	43122171	A	A	43122171	3	1	272	1	0	0	0	0	1	0	0	0	16745	1290	45	2	3381	2	TTBK2	15	43122171	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08		43122171	59409221	128	49372											
SIN3A	25942	broad.mit.edu	37	chr15	75668128	75668128	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atccagactatccacattctCcatggtcttcttgctgtttc	7	16	5	13	0	3	1	0	0	3	1	7	1	5	1	3	1	1	2	3	1	1	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr15:75668128C>G	uc002bai.2	-	20	3728	c.3469G>C	c.(3469-3471)GAG>CAG	p.E1157Q	SIN3A_uc002baj.2_Missense_Mutation_p.E1157Q|SIN3A_uc010uml.1_Missense_Mutation_p.E1157Q	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	1157					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						TCCACATTCTCCATGGTCTTC	0.463													6	131					0	0	0	0	G	75668128	G	G	75668128	3	3	272	1	0	0	0	0	1	0	0	0	14390	864	30	2	360	2	SIN3A	15	75668128	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	32545957	75668128	26863264	129	49373											
ADAMTS17	170691	broad.mit.edu	37	chr15	100594257	100594257	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccccttacccgagtctttgaGagctagaaagcaagttgaag	12	9	10	10	1	1	3	0	2	1	2	1	5	1	3	3	0	3	3	3	0	5	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr15:100594257G>C	uc002bvv.1	-	16	2219	c.2140C>G	c.(2140-2142)CTC>GTC	p.L714V		NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	714	Spacer.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		GAGTCTTTGAGAGCTAGAAAG	0.537													11	126					0	0	0	0	C	100594257	C	C	100594257	3	2	272	1	0	0	0	0	1	0	0	0	262	942	33	2	1175	2	ADAMTS17	15	100594257	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	24926129	100594257	1937135	130	49374											
C16orf73	254528	broad.mit.edu	37	chr16	1891862	1891862	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagtttcatcatcaatgttGagtgtggaaatgtaggcata	12	14	11	4	0	3	1	3	1	0	0	3	2	3	2	0	2	0	5	0	2	5	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:1891862G>C	uc002cne.2	-	11	1111	c.993C>G	c.(991-993)CTC>CTG	p.L331L	C16orf73_uc010uvq.1_Silent_p.L331L|C16orf73_uc010uvr.1_Silent_p.L124L	NM_152764	NP_689977	Q8N635	CP073_HUMAN	hypothetical protein LOC254528 isoform 2	331					meiosis	cytoplasm					0						CATCAATGTTGAGTGTGGAAA	0.328													4	37					0	0	0	0	C	1891862	C	C	1891862	2	2	272	1	0	0	0	0	0	0	0	1	1838	1277	45	2		2	C16orf73	16	1891862	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08		1891862	88462891	131	49375											
CCNF	899	broad.mit.edu	37	chr16	2495573	2495573	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcggaggaggctggtgccGcggtacaggctccagctgct	5	7	17	12	3	0	0	0	0	0	0	1	2	1	2	2	6	5	5	2	6	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:2495573G>A	uc002cqd.1	+	10	1132	c.1044G>A	c.(1042-1044)CCG>CCA	p.P348P	CCNF_uc002cqe.1_Silent_p.P40P	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	348	Cyclin N-terminal.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				GGCTGGTGCCGCGGTACAGGC	0.652													5	51					0	0	0	0	A	2495573	A	A	2495573	2	1	272	1	0	0	0	0	0	0	0	1	2937	1074	38	1		1	CCNF	16	2495573	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	603711	2495573	87859180	132	49376											
SMG1	23049	broad.mit.edu	37	chr16	18827770	18827770	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctgtctgaattgccctctGagtagacatatcctgggtca	8	13	9	11	0	4	3	1	2	3	1	5	3	5	3	2	1	1	1	2	1	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:18827770G>C	uc002dfm.2	-	58	10519	c.10156C>G	c.(10156-10158)CAG>GAG	p.Q3386E	SMG1_uc010bwb.2_Missense_Mutation_p.Q3246E|SMG1_uc010bwa.2_Missense_Mutation_p.Q2117E	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3386					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						ATTGCCCTCTGAGTAGACATA	0.413													4	61					0	0	0	0	C	18827770	C	C	18827770	3	2	272	1	0	0	0	0	1	0	0	0	14859	1299	45	2	853	2	SMG1	16	18827770	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	16332197	18827770	71526983	133	49377											
ARHGAP17	55114	broad.mit.edu	37	chr16	24955123	24955123	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccagtcggcatgctgaatGatgggttcaatcactgcaac	12	9	10	10	1	2	2	2	2	0	0	3	2	2	2	1	2	4	4	1	2	4	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:24955123G>A	uc002dnb.2	-	15	1395	c.1302C>T	c.(1300-1302)ATC>ATT	p.I434I	ARHGAP17_uc002dna.2_Silent_p.I161I|ARHGAP17_uc002dnc.2_Silent_p.I434I|ARHGAP17_uc010vcf.1_Silent_p.I255I	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	434	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CATGCTGAATGATGGGTTCAA	0.428													6	74					0	0	0	0	A	24955123	A	A	24955123	2	1	272	1	0	0	0	0	0	0	0	1	867	1280	45	2		2	ARHGAP17	16	24955123	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	6127353	24955123	65399630	134	49378											
C16orf93	90835	broad.mit.edu	37	chr16	30771928	30771928	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgcccccctcagtccctactCcctcatctcagcattggtgg	5	10	7	19	1	3	0	3	0	1	0	6	0	5	0	5	2	2	1	5	2	1	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:30771928C>G	uc002dzm.2	-	3	629	c.298G>C	c.(298-300)GAG>CAG	p.E100Q	C16orf93_uc002dzn.2_Missense_Mutation_p.E100Q|C16orf93_uc002dzo.2_Missense_Mutation_p.E63Q|C16orf93_uc002dzp.2_Missense_Mutation_p.E100Q|RNF40_uc002dzq.2_5'Flank|RNF40_uc010caa.2_5'Flank|RNF40_uc010cab.2_5'Flank|RNF40_uc010vfa.1_5'Flank|RNF40_uc002dzr.2_5'Flank|RNF40_uc010vfb.1_5'Flank	NM_001014979	NP_001014979	A1A4V9	CP093_HUMAN	hypothetical protein LOC90835	100											0						AGTCCCTACTCCCTCATCTCA	0.522													2	0					0	0	0	0	G	30771928	G	G	30771928	3	3	272	1	0	0	0	0	1	0	0	0	1852	869	30	2	725	2	C16orf93	16	30771928	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	5816805	30771928	59582825	135	49379											
NUP93	9688	broad.mit.edu	37	chr16	56839414	56839414	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctctgttcctttctggcAgaccttcggcatggctgagg	4	14	12	11	1	2	2	0	1	2	1	5	2	3	2	2	4	0	5	2	4	0	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:56839414A>T	uc002eka.2	+	5	482	c.361_splice	c.e5-2	p.T121_splice	NUP93_uc002ekb.2_Splice_Site|NUP93_uc010vhi.1_Splice_Site	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						CCTTTCTGGCAGACCTTCGGC	0.473													4	45					0	0	0	0	T	56839414	T	T	56839414	5	4	272	1	0	0	0	0	0	0	1	0	10826	202	7	5	373	5	NUP93	16	56839414	Splice_Site	SNP	A	TCGA-CX-7085-01A-21D-2012-08	26067486	56839414	33515339	136	49380											
CDH11	1009	broad.mit.edu	37	chr16	65032553	65032553	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtcctggaccttgacaatGaattccgacggtggctccag	9	10	11	11	2	0	2	0	2	0	0	3	4	3	3	4	3	0	1	4	3	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:65032553G>C	uc002eoi.2	-	4	869	c.435C>G	c.(433-435)TTC>TTG	p.F145L	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Missense_Mutation_p.F145L|CDH11_uc010vin.1_Missense_Mutation_p.F19L|CDH11_uc010vio.1_Missense_Mutation_p.F145L	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	145	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCTTGACAATGAATTCCGACG	0.567			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			3	65					0	0	0	0	C	65032553	C	C	65032553	3	2	272	1	0	0	0	0	1	0	0	0	3112	1281	45	2	1995	2	CDH11	16	65032553	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	8193139	65032553	25322200	137	49381											
CDH5	1003	broad.mit.edu	37	chr16	66423424	66423424	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacttccccttcttcacccaGagtgagcccctcctctaggg	7	10	7	17	0	3	2	1	1	2	1	5	2	5	2	6	1	2	0	6	1	2	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:66423424G>C	uc002eom.3	+	5	936	c.780G>C	c.(778-780)CAG>CAC	p.Q260H	CDH5_uc002eon.1_Missense_Mutation_p.Q260H	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	260	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		TCTTCACCCAGAGTGAGCCCC	0.602													3	40					0	0	0	0	C	66423424	C	C	66423424	3	2	272	1	0	0	0	0	1	0	0	0	3128	956	33	2	794	2	CDH5	16	66423424	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	1390871	66423424	23931329	138	49382											
DYNC1LI2	1783	broad.mit.edu	37	chr16	66759798	66759798	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagagcctgtctttttactCaacagactgttgaagaagct	11	12	10	8	0	2	4	1	1	1	3	2	5	2	4	1	1	4	2	1	1	4	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:66759798C>T	uc002eqb.1	-	12	1342	c.1311G>A	c.(1309-1311)TTG>TTA	p.L437L	DYNC1LI2_uc010vis.1_Silent_p.L360L	NM_006141	NP_006132	O43237	DC1L2_HUMAN	dynein, cytoplasmic, light intermediate	437					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|skin(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		TCTTTTTACTCAACAGACTGT	0.458													7	187					0	0	0	0	T	66759798	T	T	66759798	2	4	272	1	0	0	0	0	0	0	0	1	4867	825	29	2		2	DYNC1LI2	16	66759798	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	336374	66759798	23594955	139	49383											
NFAT5	10725	broad.mit.edu	37	chr16	69689635	69689635	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaatacaactccttgcaaaGaagtggacattgaaggcact	16	8	9	8	0	0	2	0	1	0	1	1	4	1	3	1	2	3	2	1	2	6	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:69689635G>C	uc002exm.1	+	5	2283	c.1075G>C	c.(1075-1077)GAA>CAA	p.E359Q	NFAT5_uc002exh.1_Missense_Mutation_p.E153Q|NFAT5_uc002exi.2_Missense_Mutation_p.E283Q|NFAT5_uc002exj.1_Missense_Mutation_p.E283Q|NFAT5_uc002exk.1_Missense_Mutation_p.E283Q|NFAT5_uc002exl.1_Missense_Mutation_p.E377Q|NFAT5_uc002exn.1_Missense_Mutation_p.E377Q	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	359	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TCCTTGCAAAGAAGTGGACAT	0.423													3	71					0	0	0	0	C	69689635	C	C	69689635	3	2	272	1	0	0	0	0	1	0	0	0	10414	943	33	2	1151	2	NFAT5	16	69689635	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	2929837	69689635	20665118	140	49384											
VAT1L	57687	broad.mit.edu	37	chr16	77896753	77896753	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actctgtgacccacctctttGacagaaatgcagactacgtg	11	10	8	12	1	2	4	0	2	2	2	2	4	2	4	2	0	2	1	2	0	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:77896753G>C	uc002ffg.1	+	4	785	c.688G>C	c.(688-690)GAC>CAC	p.D230H		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	230							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						CCACCTCTTTGACAGAAATGC	0.473													4	112					0	0	0	0	C	77896753	C	C	77896753	3	2	272	1	0	0	0	0	1	0	0	0	17198	1290	45	2	702	2	VAT1L	16	77896753	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	8207118	77896753	12458000	141	49385											
CNTROB	116840	broad.mit.edu	37	chr17	7838431	7838431	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagattttcaggggctgagaGatgcattggattcagagcat	11	11	13	6	0	2	4	2	1	0	3	2	6	2	5	0	3	2	3	0	3	0	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:7838431G>C	uc002gjq.2	+	5	1481	c.562G>C	c.(562-564)GAT>CAT	p.D188H	CNTROB_uc002gjp.2_Missense_Mutation_p.D188H|CNTROB_uc002gjr.2_Missense_Mutation_p.D90H|CNTROB_uc010vum.1_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	188					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				GGGGCTGAGAGATGCATTGGA	0.542													3	65					0	0	0	0	C	7838431	C	C	7838431	3	2	272	1	0	0	0	0	1	0	0	0	3666	942	33	2	576	2	CNTROB	17	7838431	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08		7838431	73356779	142	49386											
KRBA2	124751	broad.mit.edu	37	chr17	8273686	8273686	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cagctctctgaggcatcatgGagagctgtaagaaggatcct	11	9	12	9	0	2	3	1	1	1	2	4	5	3	4	1	3	2	4	1	3	2	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:8273686G>C	uc002glf.1	-	2	251	c.245C>G	c.(244-246)TCC>TGC	p.S82C	KRBA2_uc002glg.1_5'UTR	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	82	KRAB.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						AGGCATCATGGAGAGCTGTAA	0.403													5	78					0	0	0	0	C	8273686	C	C	8273686	3	2	272	1	0	0	0	0	1	0	0	0	8479	1174	41	2	1237	2	KRBA2	17	8273686	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	435255	8273686	72921524	143	49387											
KRBA2	124751	broad.mit.edu	37	chr17	8274828	8274828	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggactggggaagagacaaGagagggcaccaggaatgaag	16	2	17	6	0	0	3	0	1	0	2	0	8	0	6	1	5	0	1	1	5	4	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:8274828G>C	uc002glf.1	-	1	31	c.25C>G	c.(25-27)CTT>GTT	p.L9V	KRBA2_uc002glg.1_Intron	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	9					DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						GAAGAGACAAGAGAGGGCACC	0.483													3	56					0	0	0	0	C	8274828	C	C	8274828	3	2	272	1	0	0	0	0	1	0	0	0	8479	942	33	2	1461	2	KRBA2	17	8274828	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	1142	8274828	72920382	144	49388											
FAM83G	644815	broad.mit.edu	37	chr17	18881189	18881189	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccacggccggagctgcctGagtggctgtcctggtcactg	4	8	16	13	2	1	1	1	1	0	0	2	2	2	2	4	5	2	2	4	5	0	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:18881189G>C	uc002guw.2	-	5	1957	c.1790C>G	c.(1789-1791)TCA>TGA	p.S597*	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	597										ovary(1)|central_nervous_system(1)	2						GGAGCTGCCTGAGTGGCTGTC	0.642													11	68					0	0	0	0	C	18881189	C	C	18881189	4	2	272	1	0	0	0	0	0	1	0	0	5671	1294	45	2	689	2	FAM83G	17	18881189	Nonsense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	10606361	18881189	62314021	145	49389											
TNFAIP1	7126	broad.mit.edu	37	chr17	26669278	26669278	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatgtttttttcagcaactCtgacgaccacctgctgaaaa	11	13	6	11	1	3	2	2	2	1	0	3	3	3	2	2	0	3	3	2	0	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:26669278C>G	uc002hax.1	+	6	543	c.524C>G	c.(523-525)TCT>TGT	p.S175C	TNFAIP1_uc002hay.2_Missense_Mutation_p.S175C|TNFAIP1_uc010waf.1_Missense_Mutation_p.S71C	NM_021137	NP_066960	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1	175					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		TTCAGCAACTCTGACGACCAC	0.572													4	31					0	0	0	0	G	26669278	G	G	26669278	3	3	272	1	0	0	0	0	1	0	0	0	16338	913	32	2	542	2	TNFAIP1	17	26669278	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	7788089	26669278	54525932	146	49390											
LRRC37B	114659	broad.mit.edu	37	chr17	30349042	30349042	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcagcttctacagctccctCaggaggtagaaccttcaacc	10	8	8	15	1	3	1	2	0	1	1	4	2	4	2	3	2	5	4	3	2	4	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:30349042C>G	uc002hgu.2	+	1	888	c.877C>G	c.(877-879)CAG>GAG	p.Q293E	LRRC37B_uc010wbx.1_Missense_Mutation_p.Q211E|LRRC37B_uc010csu.2_Missense_Mutation_p.Q293E	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	293	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				ACAGCTCCCTCAGGAGGTAGA	0.522													16	127					0	0	0	0	G	30349042	G	G	30349042	3	3	272	1	0	0	0	0	1	0	0	0	9044	827	29	2	879	2	LRRC37B	17	30349042	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	3679764	30349042	50846168	147	49391											
ACACA	31	broad.mit.edu	37	chr17	35602001	35602001	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccttcctactcacctgctGaaccttgctggggttgtcca	6	12	8	15	0	1	1	1	1	0	0	3	1	3	1	5	2	4	3	5	2	2	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:35602001G>C	uc002hnm.2	-	20	2670	c.2479C>G	c.(2479-2481)CAG>GAG	p.Q827E	ACACA_uc002hnk.2_Missense_Mutation_p.Q749E|ACACA_uc002hnl.2_Missense_Mutation_p.Q769E|ACACA_uc002hnn.2_Missense_Mutation_p.Q827E|ACACA_uc002hno.2_Missense_Mutation_p.Q864E|ACACA_uc010cuz.2_Missense_Mutation_p.Q827E	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	827					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTCACCTGCTGAACCTTGCTG	0.498													20	295					0	0	0	0	C	35602001	C	C	35602001	3	2	272	1	0	0	0	0	1	0	0	0	106	1299	45	2	4709	2	ACACA	17	35602001	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	5252959	35602001	45593209	148	49392											
DDX52	11056	broad.mit.edu	37	chr17	36003614	36003614	+	5'Flank	DEL	T	-	-																															gtactccgtcattatttatcTtttttttttttttttgaaac																										TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:36003614delT	uc002hoi.1	-						DDX52_uc002hoh.1_5'Flank|DDX52_uc002hoj.1_5'Flank	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a							nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				ATTAtttatcttttttttttt	0.244													---	---	---								-	36003614	-	-	36003614	6	5	272	0	1	1	0	1	0	0	0	0	4387	1624	56	0		0	DDX52	17	36003614	5'Flank	DEL	T	TCGA-CX-7085-01A-21D-2012-08	401613	36003614	45191596	149	49393											
NPEPPS	9520	broad.mit.edu	37	chr17	45662950	45662950	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cacctgttatgtctacatatCtggtggcatttgttgtgggt	6	17	11	7	0	2	0	0	0	2	0	2	0	2	0	1	3	1	3	1	3	3	5			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:45662950C>G	uc002ilr.3	+	6	956	c.733C>G	c.(733-735)CTG>GTG	p.L245V	NPEPPS_uc010wkt.1_Missense_Mutation_p.L241V|NPEPPS_uc010wku.1_Missense_Mutation_p.L209V|NPEPPS_uc010dba.1_Missense_Mutation_p.L90V|NPEPPS_uc010wkv.1_5'Flank	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	245					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						GTCTACATATCTGGTGGCATT	0.403													19	133					0	0	0	0	G	45662950	G	G	45662950	3	3	272	1	0	0	0	0	1	0	0	0	10629	912	32	2	755	2	NPEPPS	17	45662950	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	9659336	45662950	35532260	150	49394											
KCNH6	81033	broad.mit.edu	37	chr17	61621693	61621693	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccccaaggcacagccccCaaagccctcaggaagaccca	12	2	8	19	0	1	1	1	0	0	1	1	2	1	2	6	2	3	1	6	2	3	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:61621693C>G	uc002jay.2	+	12	2505	c.2425C>G	c.(2425-2427)CAA>GAA	p.Q809E	KCNH6_uc010wpl.1_Missense_Mutation_p.Q650E|KCNH6_uc010wpm.1_Missense_Mutation_p.Q773E|KCNH6_uc002jaz.1_Missense_Mutation_p.Q720E	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	809	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	GCACAGCCCCCAAAGCCCTCA	0.617													5	35					0	0	0	0	G	61621693	G	G	61621693	3	3	272	1	0	0	0	0	1	0	0	0	8075	595	21	4	2471	4	KCNH6	17	61621693	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	15958743	61621693	19573517	151	49395											
DDX42	11325	broad.mit.edu	37	chr17	61889312	61889312	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaaatgaagatgtgacacaGattgtggagattctccattc	13	11	10	7	0	1	5	0	2	1	3	3	6	1	5	1	1	0	1	1	1	2	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:61889312G>C	uc002jbu.2	+	15	1676	c.1419G>C	c.(1417-1419)CAG>CAC	p.Q473H	DDX42_uc002jbv.2_Missense_Mutation_p.Q473H|DDX42_uc002jbw.1_Missense_Mutation_p.Q209H|DDX42_uc002jbx.2_Missense_Mutation_p.Q209H|DDX42_uc002jby.2_Missense_Mutation_p.Q19H	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	473					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						ATGTGACACAGATTGTGGAGA	0.443													27	275					0	0	0	0	C	61889312	C	C	61889312	3	2	272	1	0	0	0	0	1	0	0	0	4379	933	33	2	1469	2	DDX42	17	61889312	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	267619	61889312	19305898	152	49396											
YES1	7525	broad.mit.edu	37	chr18	743308	743308	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcctagtttaacctctagtcGcaaagattctcgagggattt	10	14	8	9	2	2	1	0	0	2	1	5	3	3	2	2	1	1	2	2	1	4	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr18:743308G>A	uc002kky.2	-	7	1053	c.832C>T	c.(832-834)CGA>TGA	p.R278*	YES1_uc002kkz.2_Nonsense_Mutation_p.R278*	NM_005433	NP_005424	P07947	YES_HUMAN	viral oncogene yes-1 homolog 1	278	Protein kinase.				blood coagulation|leukocyte migration|regulation of vascular permeability|T cell costimulation	cytosol|plasma membrane	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|ovary(1)	3					Dasatinib(DB01254)	ACCTCTAGTCGCAAAGATTCT	0.423													8	55					0	0	0	0	A	743308	A	A	743308	4	1	272	1	0	0	0	0	0	1	0	0	17542	1095	38	1	823	1	YES1	18	743308	Nonsense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08		743308	77333940	153	49397											
ZNF407	55628	broad.mit.edu	37	chr18	72345521	72345521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagacctaaaggtaacatctCacggacgtgttcacactgtg	12	9	10	10	2	2	1	2	0	1	1	3	3	2	2	1	2	1	2	1	2	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr18:72345521C>T	uc002llw.2	+	1	2603	c.2546C>T	c.(2545-2547)TCA>TTA	p.S849L	ZNF407_uc010xfc.1_Missense_Mutation_p.S849L|ZNF407_uc010dqu.1_Missense_Mutation_p.S849L|ZNF407_uc002llu.2_Missense_Mutation_p.S848L	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	849					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGTAACATCTCACGGACGTGT	0.438													8	74					0	0	0	0	T	72345521	T	T	72345521	3	4	272	1	0	0	0	0	1	0	0	0	17954	838	29	2	2548	2	ZNF407	18	72345521	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	71602213	72345521	5731727	154	49398											
GNA15	2769	broad.mit.edu	37	chr19	3155896	3155896	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaacgtgatcgccctcatCtacctggcctcactgagtga	9	9	10	13	2	3	4	2	3	1	1	4	5	3	4	3	1	2	0	3	1	2	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:3155896C>G	uc002lxf.2	+	5	948	c.690C>G	c.(688-690)ATC>ATG	p.I230M		NM_002068	NP_002059	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein),	230					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		TCGCCCTCATCTACCTGGCCT	0.602													3	48					0	0	0	0	G	3155896	G	G	3155896	3	3	272	1	0	0	0	0	1	0	0	0	6540	903	32	2	708	2	GNA15	19	3155896	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08		3155896	55973087	155	49399											
DPY19L3	147991	broad.mit.edu	37	chr19	32954294	32954294	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attctacaaatcaacaatccGtgggtaaaatggaaaaaggc	18	8	8	7	1	2	0	1	0	1	0	3	1	3	1	1	3	2	1	1	3	8	3	rs148244577	byFrequency	TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:32954294G>A	uc002ntg.2	+	13	1521	c.1345G>A	c.(1345-1347)GTG>ATG	p.V449M	DPY19L3_uc002nth.1_Missense_Mutation_p.V449M|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	449						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					TCAACAATCCGTGGGTAAAAT	0.338													6	52					0	0	0	0	A	32954294	A	A	32954294	3	1	272	1	0	0	0	0	1	0	0	0	4764	1145	40	1	1391	1	DPY19L3	19	32954294	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	29798398	32954294	26174689	156	49400											
KIRREL2	84063	broad.mit.edu	37	chr19	36357106	36357106	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgaggagtcagtgtgagcctGagccttggcgaagcccctgg	7	7	16	11	2	1	2	1	2	0	0	1	5	1	3	4	3	3	0	4	3	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:36357106G>A	uc002ocb.3	+	15	2051	c.1839G>A	c.(1837-1839)CTG>CTA	p.L613L	KIRREL2_uc002obz.3_Intron|KIRREL2_uc002oca.3_Intron|KIRREL2_uc002occ.3_Silent_p.L560L|KIRREL2_uc002ocd.3_Silent_p.L575L|APLP1_uc010xsz.1_5'Flank|APLP1_uc002oce.2_5'Flank|APLP1_uc002ocf.2_5'Flank|APLP1_uc002ocg.2_5'Flank	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	613	Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTGTGAGCCTGAGCCTTGGCG	0.607													12	98					0	0	0	0	A	36357106	A	A	36357106	2	1	272	1	0	0	0	0	0	0	0	1	8364	1277	45	2		2	KIRREL2	19	36357106	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	3402812	36357106	22771877	157	49401											
LTBP4	8425	broad.mit.edu	37	chr19	41122917	41122917	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcagcccacgccagggggcGgatgccagggtgggtgtcca	7	5	17	12	2	1	0	1	0	0	0	2	1	2	1	4	5	2	0	4	5	0	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:41122917G>A	uc002ooh.1	+	23	3136	c.3136G>A	c.(3136-3138)GGA>AGA	p.G1046R	LTBP4_uc002oog.1_Missense_Mutation_p.G1009R|LTBP4_uc002ooi.1_Missense_Mutation_p.G979R|LTBP4_uc002ooj.1_5'UTR|LTBP4_uc002ook.1_Intron|LTBP4_uc002ool.1_Intron|LTBP4_uc002oom.1_Intron|LTBP4_uc010xvp.1_Intron	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1046	Cys-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCCAGGGGGCGGATGCCAGGG	0.602													8	49					0	0	0	0	A	41122917	A	A	41122917	3	1	272	1	0	0	0	0	1	0	0	0	9126	1117	39	1	3519	1	LTBP4	19	41122917	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	4765811	41122917	18006066	158	49402											
CLPTM1	1209	broad.mit.edu	37	chr19	45490456	45490456	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgtgaagttcgacgccgtGagcggtgactactatcccat	9	10	12	10	4	0	3	0	3	0	0	2	5	1	3	2	1	2	1	2	1	3	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:45490456G>A	uc002pai.2	+	8	828	c.813G>A	c.(811-813)GTG>GTA	p.V271V	CLPTM1_uc010ejv.1_Silent_p.V169V|CLPTM1_uc010xxf.1_Silent_p.V169V|CLPTM1_uc010xxg.1_Silent_p.V257V	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	271	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		TCGACGCCGTGAGCGGTGACT	0.612													17	157					0	0	0	0	A	45490456	A	A	45490456	2	1	272	1	0	0	0	0	0	0	0	1	3569	1277	45	2		2	CLPTM1	19	45490456	Silent	SNP	G	TCGA-CX-7085-01A-21D-2012-08	4367539	45490456	13638527	159	49403											
SPHK2	56848	broad.mit.edu	37	chr19	49129394	49129394	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtggcctggtcccgttggccGaggtctcaggctgctgcacc	3	9	15	14	2	1	0	1	0	1	0	3	1	2	0	4	5	2	4	4	5	0	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:49129394G>A	uc002pjr.2	+	3	652	c.286G>A	c.(286-288)GAG>AAG	p.E96K	SPHK2_uc010xzt.1_Missense_Mutation_p.E37K|SPHK2_uc002pjs.2_Missense_Mutation_p.E96K|SPHK2_uc002pjt.2_Intron|SPHK2_uc002pju.2_Missense_Mutation_p.E60K|SPHK2_uc002pjv.2_Missense_Mutation_p.E60K|SPHK2_uc002pjw.2_Missense_Mutation_p.E158K|SPHK2_uc010xzu.1_Missense_Mutation_p.E60K	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	96	Required for binding to sulfatide and phosphoinositides and for membrane localization.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CCCGTTGGCCGAGGTCTCAGG	0.587													8	47					0	0	0	0	A	49129394	A	A	49129394	3	1	272	1	0	0	0	0	1	0	0	0	15113	1059	37	1	292	1	SPHK2	19	49129394	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	3638938	49129394	9999589	160	49404											
ZNF836	162962	broad.mit.edu	37	chr19	52658816	52658816	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgatatcttgcaagttttGaactttggataaatgcccct	10	16	8	7	0	1	2	0	2	1	0	1	3	1	3	2	1	3	2	2	1	5	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:52658816G>C	uc010ydi.1	-	5	2494	c.2120C>G	c.(2119-2121)TCA>TGA	p.S707*	ZNF836_uc010ydj.1_Nonsense_Mutation_p.S707*	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	707	C2H2-type 18; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCAAGTTTTGAACTTTGGAT	0.398													11	59					0	0	0	0	C	52658816	C	C	52658816	4	2	272	1	0	0	0	0	0	1	0	0	18254	1294	45	2	692	2	ZNF836	19	52658816	Nonsense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	3529422	52658816	6470167	161	49405											
MYADM	91663	broad.mit.edu	37	chr19	54377026	54377026	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttctccgtgaccctgatCatcctcatcgtggagctgtg	5	13	10	13	2	3	2	2	2	1	0	6	3	4	3	3	1	2	2	3	1	0	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:54377026C>G	uc002qcl.2	+	3	391	c.243C>G	c.(241-243)ATC>ATG	p.I81M	MYADM_uc002qcm.2_Missense_Mutation_p.I81M|MYADM_uc002qcn.2_Missense_Mutation_p.I81M|MYADM_uc002qco.2_Missense_Mutation_p.I81M|MYADM_uc002qcp.2_Missense_Mutation_p.I81M	NM_001020820	NP_001018656	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	81	MARVEL 1.|Helical; (Potential).			Missing (in Ref. 4; BAC04265).		integral to membrane				ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		TGACCCTGATCATCCTCATCG	0.642											OREG0003650	type=REGULATORY REGION|Gene=MYADM|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	123					0	0	0	0	G	54377026	G	G	54377026	3	3	272	1	0	0	0	0	1	0	0	0	10059	816	29	2	245	2	MYADM	19	54377026	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	1718210	54377026	4751957	162	49406											
FCAR	2204	broad.mit.edu	37	chr19	55401062	55401062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacttgatccgcatggccGtggcaggactggtcctcgtg	7	9	14	11	3	0	2	0	1	0	1	3	3	2	3	3	4	1	2	3	4	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:55401062G>A	uc002qhr.1	+	5	894	c.697G>A	c.(697-699)GTG>ATG	p.V233M	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Missense_Mutation_p.V184M|FCAR_uc010esi.1_Missense_Mutation_p.V110M|FCAR_uc002qhu.1_Missense_Mutation_p.V137M|FCAR_uc002qhv.1_Missense_Mutation_p.V211M|FCAR_uc002qhw.1_Missense_Mutation_p.V221M|FCAR_uc002qhx.1_Missense_Mutation_p.V125M|FCAR_uc002qhy.1_Missense_Mutation_p.V199M|FCAR_uc002qhz.1_Missense_Mutation_p.R196H|FCAR_uc002qia.1_Missense_Mutation_p.V124M	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	233	Helical; (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		CCGCATGGCCGTGGCAGGACT	0.527													31	387					0	0	0	0	A	55401062	A	A	55401062	3	1	272	1	0	0	0	0	1	0	0	0	5805	1145	40	1	786	1	FCAR	19	55401062	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	1024036	55401062	3727921	163	49407											
ZNF274	10782	broad.mit.edu	37	chr19	58697097	58697097	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaaccagtgacctttgaaGatgtaacactgggttttacc	12	11	10	8	0	0	3	0	2	0	1	0	4	0	4	3	2	3	2	3	2	4	4			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:58697097G>A	uc002qrq.1	+	3	511	c.52G>A	c.(52-54)GAT>AAT	p.D18N	ZNF274_uc010yhu.1_RNA|ZNF274_uc010yhv.1_Intron|ZNF274_uc002qrr.1_Missense_Mutation_p.D18N|ZNF274_uc002qrs.1_Intron|ZNF274_uc010eum.1_5'UTR	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	18	KRAB 1.				viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		GACCTTTGAAGATGTAACACT	0.517													12	97					0	0	0	0	A	58697097	A	A	58697097	3	1	272	1	0	0	0	0	1	0	0	0	17876	942	33	2	58	2	ZNF274	19	58697097	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	3296035	58697097	431886	164	49408											
CHMP2A	27243	broad.mit.edu	37	chr19	59063499	59063499	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctccttcatatccatgatCtctgcctgccgctcaaactc	7	13	4	17	1	3	1	2	1	1	0	8	1	6	1	5	0	3	1	5	0	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:59063499C>T	uc002qti.2	-	3	828	c.402G>A	c.(400-402)GAG>GAA	p.E134E	CHMP2A_uc002qtj.2_Silent_p.E134E|CHMP2A_uc002qtk.2_Silent_p.E134E	NM_198426	NP_940818	O43633	CHM2A_HUMAN	chromatin modifying protein 2A	134	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TATCCATGATCTCTGCCTGCC	0.512													12	186					0	0	0	0	T	59063499	T	T	59063499	2	4	272	1	0	0	0	0	0	0	0	1	3369	912	32	2		2	CHMP2A	19	59063499	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	366402	59063499	65484	165	49409											
ITPA	3704	broad.mit.edu	37	chr20	3194643	3194643	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcaggtacaggggcccGtgctggttgaggacacttgt	6	10	16	9	1	0	1	0	1	0	0	0	2	0	2	1	5	4	5	1	5	1	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr20:3194643G>A	uc002wid.2	+	4	344	c.202G>A	c.(202-204)GTG>ATG	p.V68M	ITPA_uc002wie.2_Missense_Mutation_p.V51M|ITPA_uc002wif.2_RNA	NM_033453	NP_258412	Q9BY32	ITPA_HUMAN	inosine triphosphatase isoform a	68					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			ovary(1)	1						ACAGGGGCCCGTGCTGGTTGA	0.627													6	89					0	0	0	0	A	3194643	A	A	3194643	3	1	272	1	0	0	0	0	1	0	0	0	7954	1145	40	1	216	1	ITPA	20	3194643	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08		3194643	59830877	166	49410											
CEP250	11190	broad.mit.edu	37	chr20	34091328	34091328	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agctgatgcaggaacgggcaGaggaagggaagggcccaagt	13	3	18	7	1	0	2	0	1	0	1	0	5	0	5	1	5	3	3	1	5	4	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr20:34091328G>C	uc002xcm.2	+	31	5802	c.5131G>C	c.(5131-5133)GAG>CAG	p.E1711Q	CEP250_uc010zve.1_Missense_Mutation_p.E1079Q	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1711	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGAACGGGCAGAGGAAGGGAA	0.582													6	122					0	0	0	0	C	34091328	C	C	34091328	3	2	272	1	0	0	0	0	1	0	0	0	3267	943	33	2	5237	2	CEP250	20	34091328	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	30896685	34091328	28934192	167	49411											
HMGXB4	10042	broad.mit.edu	37	chr22	35658315	35658315	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttccttctttgtttctcaGacctggtcctgtagacggga	5	17	9	10	1	2	2	1	0	2	2	5	3	4	3	3	2	0	2	3	2	1	6			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr22:35658315G>C	uc003anl.2	+	2	107	c.-67_splice	c.e2-1		HMGXB4_uc011amh.1_Intron|HMGXB4_uc003ank.2_Splice_Site	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1						endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						TTGTTTCTCAGACCTGGTCCT	0.512													11	119					0	0	0	0	C	35658315	C	C	35658315	5	2	272	1	0	0	0	0	0	0	1	0	7278	956	33	2		2	HMGXB4	22	35658315	Splice_Site	SNP	G	TCGA-CX-7085-01A-21D-2012-08		35658315	15646251	168	49412											
PACSIN2	11252	broad.mit.edu	37	chr22	43272940	43272940	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actgacggtgctgcccgtgtCgtcctcatcctcgaaggggt	5	10	13	13	4	1	1	1	1	0	0	5	2	3	1	3	3	2	1	3	3	1	0			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr22:43272940C>T	uc010gzg.2	-	9	1327	c.1105G>A	c.(1105-1107)GAC>AAC	p.D369N	PACSIN2_uc003bdg.3_Missense_Mutation_p.D369N|PACSIN2_uc003bde.3_Missense_Mutation_p.D369N|PACSIN2_uc003bdf.3_Intron	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	369					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				CTGCCCGTGTCGTCCTCATCC	0.567													12	164					0	0	0	0	T	43272940	T	T	43272940	3	4	272	1	0	0	0	0	1	0	0	0	11429	884	31	1	367	1	PACSIN2	22	43272940	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	7614625	43272940	8031626	169	49413											
PLXNB2	23654	broad.mit.edu	37	chr22	50728422	50728422	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgtggtccgtgtaggcttCaaaggcctccctgctgtcag	5	10	14	12	2	2	0	2	0	0	0	4	0	4	0	3	4	1	3	3	4	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr22:50728422C>T	uc003bkv.3	-	3	698	c.592G>A	c.(592-594)GAA>AAA	p.E198K		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	198	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GTGTAGGCTTCAAAGGCCTCC	0.607													5	57					0	0	0	0	T	50728422	T	T	50728422	3	4	272	1	0	0	0	0	1	0	0	0	12179	835	29	2	5064	2	PLXNB2	22	50728422	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	7455482	50728422	576144	170	49414											
FAM48B2	170067	broad.mit.edu	37	chrX	24330433	24330433	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcatgtctgaaagggtcttCtacctcctgggctggccaga	7	11	12	11	0	3	2	0	1	3	1	4	2	4	2	3	3	2	2	3	3	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:24330433C>G	uc011mjw.1	-	1	1000	c.1000G>C	c.(1000-1002)GAA>CAA	p.E334Q		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	334											0						AAAGGGTCTTCTACCTCCTGG	0.537													15	186					0	0	0	0	G	24330433	G	G	24330433	3	3	272	1	0	0	0	0	1	0	0	0	5606	922	32	2	1456	2	FAM48B2	23	24330433	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08		24330433	130940127	171	49415											
PHF16	9767	broad.mit.edu	37	chrX	46887308	46887308	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcaggttgtgggccagttGatgagaatcttatggaaaag	11	11	15	4	0	1	2	0	2	1	1	1	4	1	3	1	3	1	3	1	3	4	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:46887308G>A	uc004dgx.2	+	6	541	c.490G>A	c.(490-492)GAT>AAT	p.D164N	PHF16_uc004dgy.2_Missense_Mutation_p.D164N	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	164					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						TGGGCCAGTTGATGAGAATCT	0.458													8	61					0	0	0	0	A	46887308	A	A	46887308	3	1	272	1	0	0	0	0	1	0	0	0	11882	1290	45	2	508	2	PHF16	23	46887308	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	22556875	46887308	108383252	172	49416											
SPIN3	169981	broad.mit.edu	37	chrX	57020780	57020780	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtctatgacttctcctggctCcctctctgccagaggagaat	7	12	9	13	0	3	3	0	1	3	2	6	4	4	3	3	2	1	1	3	2	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:57020780C>T	uc010nkj.2	-	2	887	c.601G>A	c.(601-603)GAG>AAG	p.E201K	SPIN3_uc004duu.3_Intron|SPIN3_uc004duw.3_Intron|SPIN3_uc004duv.3_Intron|SPIN3_uc004dux.1_Missense_Mutation_p.E201K	NM_001010862	NP_001010862	Q5JUX0	SPIN3_HUMAN	spindlin family, member 3	201					gamete generation					ovary(1)|central_nervous_system(1)	2						TCTCCTGGCTCCCTCTCTGCC	0.463													11	63					0	0	0	0	T	57020780	T	T	57020780	3	4	272	1	0	0	0	0	1	0	0	0	15121	864	30	2	179	2	SPIN3	23	57020780	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	10133472	57020780	98249780	173	49417											
HEPH	9843	broad.mit.edu	37	chrX	65486458	65486458	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgacagagaaagctacgaCgcaataggaggtccatcctg	14	6	11	10	3	0	1	0	0	0	1	3	5	2	2	2	2	2	2	2	2	4	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:65486458C>T	uc011moz.1	+	21	3490	c.3430C>T	c.(3430-3432)CGC>TGC	p.R1144C	HEPH_uc004dwn.2_Missense_Mutation_p.R1143C|HEPH_uc004dwo.2_Missense_Mutation_p.R874C|HEPH_uc010nkr.2_Missense_Mutation_p.R952C|HEPH_uc011mpa.1_Missense_Mutation_p.R1144C	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1141	Cytoplasmic (Potential).				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						AAAGCTACGACGCAATAGGAG	0.498													5	48					0	0	0	0	T	65486458	T	T	65486458	3	4	272	1	0	0	0	0	1	0	0	0	7093	536	19	1	3665	1	HEPH	23	65486458	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	8465678	65486458	89784102	174	49418											
XKRX	402415	broad.mit.edu	37	chrX	100177939	100177939	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcccacctcccattctatCagcacctcctcgccatctat	7	11	4	19	1	3	0	1	0	2	0	6	0	5	0	6	1	1	1	6	1	2	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:100177939C>G	uc004egn.2	-	2	1052	c.447G>C	c.(445-447)CTG>CTC	p.L149L	XKRX_uc011mre.1_Intron	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	149						integral to membrane|plasma membrane				breast(1)	1						CCCATTCTATCAGCACCTCCT	0.547													6	157					0	0	0	0	G	100177939	G	G	100177939	2	3	272	1	0	0	0	0	0	0	0	1	17507	813	29	2		2	XKRX	23	100177939	Silent	SNP	C	TCGA-CX-7085-01A-21D-2012-08	34691481	100177939	55092621	175	49419											
GRIA3	2892	broad.mit.edu	37	chrX	122551330	122551330	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatttttcaaagccattcatGagcctgggcatctccatcat	10	13	7	11	0	4	1	3	1	1	0	5	2	4	1	3	1	2	1	3	1	1	3			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:122551330G>C	uc004etq.3	+	12	1871	c.1578G>C	c.(1576-1578)ATG>ATC	p.M526I	GRIA3_uc004etr.3_Missense_Mutation_p.M526I|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.M510I	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	526	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	AGCCATTCATGAGCCTGGGCA	0.398													9	217					0	0	0	0	C	122551330	C	C	122551330	3	2	272	1	0	0	0	0	1	0	0	0	6808	1290	45	2	1620	2	GRIA3	23	122551330	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	22373391	122551330	32719230	176	49420											
THOC2	57187	broad.mit.edu	37	chrX	122747943	122747943	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttttcatcttttttctctCtttctctggatctttccctt	2	24	2	13	0	6	0	1	0	5	0	9	1	7	1	2	1	0	0	2	1	0	8			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:122747943C>T	uc004etu.2	-	34	4441	c.4409G>A	c.(4408-4410)AGA>AAA	p.R1470K	THOC2_uc010nqt.1_RNA|THOC2_uc004etw.1_Missense_Mutation_p.R291K	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1470	Lys-rich.|Potential.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TTTTTTCTCTCTTTCTCTGGA	0.378													8	111					0	0	0	0	T	122747943	T	T	122747943	3	4	272	1	0	0	0	0	1	0	0	0	15931	913	32	2	392	2	THOC2	23	122747943	Missense_Mutation	SNP	C	TCGA-CX-7085-01A-21D-2012-08	196613	122747943	32522617	177	49421											
MAGEC1	9947	broad.mit.edu	37	chrX	140993500	140993500	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaattctcagagttctcctGaggggaaggactccctgtct	9	11	11	10	0	3	3	1	1	3	2	6	5	4	5	2	3	0	1	2	3	2	2			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:140993500G>C	uc004fbt.2	+	4	596	c.310G>C	c.(310-312)GAG>CAG	p.E104Q	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	104							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTTCTCCTGAGGGGAAGGA	0.562										HNSCC(15;0.026)			11	130					0	0	0	0	C	140993500	C	C	140993500	3	2	272	1	0	0	0	0	1	0	0	0	9233	1291	45	2	316	2	MAGEC1	23	140993500	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	18245557	140993500	14277060	178	49422											
ABCD1	215	broad.mit.edu	37	chrX	153006171	153006171	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccacatcctgcagcgggaggGaggtaggaggcctggggctg	7	5	19	10	1	0	0	0	0	0	0	1	3	1	3	3	7	2	3	3	7	1	1			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:153006171G>C	uc004fif.2	+	7	2177	c.1778G>C	c.(1777-1779)GGA>GCA	p.G593A	ABCD1_uc004fig.2_Missense_Mutation_p.G93A|ABCD1_uc004fih.2_5'Flank	NM_000033	NP_000024	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member	593	ABC transporter.				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGCGGGAGGGAGGTAGGAGG	0.612													10	71					0	0	0	0	C	153006171	C	C	153006171	3	2	272	1	0	0	0	0	1	0	0	0	60	1174	41	2	1804	2	ABCD1	23	153006171	Missense_Mutation	SNP	G	TCGA-CX-7085-01A-21D-2012-08	12012671	153006171	2264389	179	49423											
CDK11B	984	broad.mit.edu	37	chr1	1650883	1650885	+	In_Frame_Del	DEL	TCT	-	-																															gtttgatggccaaagaatcaTcttcttctcctctgaaataa																								rs147453611	by1000genomes	TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:1650883_1650885delTCT	uc001agv.1	-	6	348_350	c.237_239delAGA	c.(235-240)GAAGAT>GAT	p.E79del	CDK11B_uc001ags.1_5'Flank|CDK11B_uc001agt.1_5'Flank|CDK11B_uc001aha.1_In_Frame_Del_p.E45del|CDK11B_uc001agw.1_In_Frame_Del_p.E45del|CDK11B_uc001agy.1_In_Frame_Del_p.E79del|CDK11B_uc001agx.1_In_Frame_Del_p.E79del|CDK11B_uc001agz.1_Translation_Start_Site|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc009vkr.2_In_Frame_Del_p.E79del|CDK11A_uc009vks.2_In_Frame_Del_p.E79del|CDK11A_uc010nys.1_In_Frame_Del_p.E79del|CDK11A_uc010nyt.1_In_Frame_Del_p.E79del|CDK11A_uc010nyu.1_RNA|CDK11A_uc009vkt.1_In_Frame_Del_p.E79del|CDK11A_uc009vku.1_In_Frame_Del_p.E79del|CDK11A_uc009vkv.1_In_Frame_Del_p.E79del|CDK11A_uc001aht.1_In_Frame_Del_p.E79del|CDK11B_uc001ahu.1_In_Frame_Del_p.E79del|CDK11B_uc001ahv.1_In_Frame_Del_p.E79del|CDK11B_uc001ahw.1_In_Frame_Del_p.E79del	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	79					apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CAAAGAATCATCTTCTTCTCCTC	0.394													---	---	---								-	1650885	-	-	1650883	7	5	273	1	0	1	0	1	0	0	0	0	3142	1435	50	0	2198	0	CDK11B	1	1650883	In_Frame_Del	DEL	TCT	TCGA-CX-7086-01A-11D-2078-08		1650883	247599738	1	49424											
KAZ	23254	broad.mit.edu	37	chr1	15287295	15287295	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcggcaagtcctctgaggtCctctcggccaccgagctcag	6	7	13	15	3	3	1	1	1	2	0	6	2	5	1	4	4	1	2	4	4	1	0	rs150589352	byFrequency	TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:15287295C>T	uc001avm.3	+	2	623	c.342C>T	c.(340-342)GTC>GTT	p.V114V	KAZ_uc009vog.1_Silent_p.V114V|KAZ_uc010obj.1_Silent_p.V114V|KAZ_uc001avo.2_Silent_p.V108V|KAZ_uc001avp.2_Silent_p.V20V|KAZ_uc001avq.2_Silent_p.V20V|KAZ_uc001avr.2_Silent_p.V17V	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	114	Potential.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						CCTCTGAGGTCCTCTCGGCCA	0.612													7	10					0	0	0	0	T	15287295	T	T	15287295	2	4	273	1	0	0	0	0	0	0	0	1	8027	842	30	2		2	KAZ	1	15287295	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	13636412	15287295	233963326	2	49425											
ZNF436	80818	broad.mit.edu	37	chr1	23689135	23689136	+	Frame_Shift_Ins	INS	-	CA	CA																															ctcacactcatagggtttctINScaccactgtgggtcctttgg																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:23689135_23689136insCA	uc001bgt.2	-	3	1120_1121	c.739_740insTG	c.(739-741)GAGfs	p.E247fs	ZNF436_uc001bgu.2_Frame_Shift_Ins_p.E247fs	NM_030634	NP_085137	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		ATAGGGTTTCTCACCACTGTGG	0.5													---	---	---								CA	23689136	CA	CA	23689135	7	5	273	1	0	1	1	0	0	0	0	0	17976	1551	54	0	676	0	ZNF436	1	23689135	Frame_Shift_Ins	INS	-	TCGA-CX-7086-01A-11D-2078-08	8401840	23689135	225561486	3	49426											
EIF2C1	26523	broad.mit.edu	37	chr1	36379463	36379463	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaggtgaaacgtgtcggaGatacactcttgggaatggct	10	10	14	7	2	1	3	0	2	1	1	2	5	1	4	0	4	2	1	0	4	3	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:36379463G>A	uc001bzl.2	+	13	1816	c.1603G>A	c.(1603-1605)GAT>AAT	p.D535N	EIF2C1_uc001bzk.2_Missense_Mutation_p.D460N|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	535	Piwi.				negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACGTGTCGGAGATACACTCTT	0.363													11	72					0	0	0	0	A	36379463	A	A	36379463	3	1	273	1	0	0	0	0	1	0	0	0	5027	942	33	2	1653	2	EIF2C1	1	36379463	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	12690328	36379463	212871158	4	49427											
MRPS15	64960	broad.mit.edu	37	chr1	36921787	36921787	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agccgcaattctgactcgtaCccgaatgcacagagccttct	10	9	8	14	3	2	2	0	1	2	1	3	3	2	2	3	0	4	3	3	0	3	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:36921787C>G	uc001cas.2	-	7	800	c.636_splice	c.e7+1	p.R212_splice		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor						translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTGACTCGTACCCGAATGCAC	0.552													9	48					0	0	0	0	G	36921787	G	G	36921787	5	3	273	1	0	0	0	0	0	0	1	0	9878	521	18	4	144	4	MRPS15	1	36921787	Splice_Site	SNP	C	TCGA-CX-7086-01A-11D-2078-08	542324	36921787	212328834	5	49428											
GRIK3	2899	broad.mit.edu	37	chr1	37271712	37271712	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccctcgctcacccatgggCgtgccgatgccgtagccctt	4	8	11	18	4	1	0	1	0	0	0	2	1	1	0	6	1	3	2	6	1	1	2	rs114469448	by1000genomes	TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:37271712C>T	uc001caz.2	-	14	2442	c.2307G>A	c.(2305-2307)ACG>ACA	p.T769T	GRIK3_uc001cba.1_Silent_p.T769T	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	769	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CACCCATGGGCGTGCCGATGC	0.647													12	35					0	0	0	0	T	37271712	T	T	37271712	2	4	273	1	0	0	0	0	0	0	0	1	6814	755	27	1		1	GRIK3	1	37271712	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	349925	37271712	211978909	6	49429											
HPDL	84842	broad.mit.edu	37	chr1	45793381	45793381	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacgactgcctgggcttttgCcacttgccgctgagcccagg	5	9	12	15	2	0	1	0	1	0	0	0	2	0	1	4	2	4	2	4	2	0	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:45793381C>T	uc001cne.2	+	1	837	c.561C>T	c.(559-561)TGC>TGT	p.C187C		NM_032756	NP_116145	Q96IR7	HPDL_HUMAN	glyoxalase domain containing 1	187					aromatic amino acid family metabolic process		4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	Acute lymphoblastic leukemia(166;0.155)					TGGGCTTTTGCCACTTGCCGC	0.672													3	35					0	0	0	0	T	45793381	T	T	45793381	2	4	273	1	0	0	0	0	0	0	0	1	7372	747	26	4		4	HPDL	1	45793381	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	8521669	45793381	203457240	7	49430											
NASP	4678	broad.mit.edu	37	chr1	46073825	46073825	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaggactagaggagaaggtCagggcaaagctggttcctag	12	7	15	7	0	2	2	2	0	0	2	3	4	3	3	1	5	1	3	1	5	4	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:46073825C>G	uc001coi.1	+	6	1344	c.1242C>G	c.(1240-1242)GTC>GTG	p.V414V	NASP_uc010olq.1_Silent_p.V377V|NASP_uc001coh.1_Silent_p.V416V|NASP_uc001coj.1_Intron|NASP_uc010olr.1_Silent_p.V350V|NASP_uc001cok.1_Silent_p.V297V	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	414	Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					AGGAGAAGGTCAGGGCAAAGC	0.493													11	46					0	0	0	0	G	46073825	G	G	46073825	2	3	273	1	0	0	0	0	0	0	0	1	10225	813	29	2		2	NASP	1	46073825	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	280444	46073825	203176796	8	49431											
NRD1	4898	broad.mit.edu	37	chr1	52287187	52287187	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacttgtttggtatctgagaGaagatttcagtcacccactt	10	15	8	8	0	3	3	2	1	1	2	3	4	3	3	1	1	1	2	1	1	3	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:52287187G>C	uc001ctc.3	-	10	1726	c.1404C>G	c.(1402-1404)TTC>TTG	p.F468L	NRD1_uc009vzb.2_Missense_Mutation_p.F163L|NRD1_uc001ctd.3_Missense_Mutation_p.F400L|NRD1_uc001cte.2_Missense_Mutation_p.F336L|NRD1_uc001ctf.2_Missense_Mutation_p.F400L|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.F268L	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	399					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						GTATCTGAGAGAAGATTTCAG	0.254													4	33					0	0	0	0	C	52287187	C	C	52287187	3	2	273	1	0	0	0	0	1	0	0	0	10699	933	33	2	2351	2	NRD1	1	52287187	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	6213362	52287187	196963434	9	49432											
CACHD1	57685	broad.mit.edu	37	chr1	64936610	64936610	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctggcggccgaggagctgggGgtcgtcaccatgcaggtaag	7	6	18	10	3	1	0	1	0	0	0	2	2	1	1	2	6	2	3	2	6	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:64936610G>A	uc001dbo.1	+	1	135	c.30G>A	c.(28-30)GGG>GGA	p.G10G		NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	61	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						AGGAGCTGGGGGTCGTCACCA	0.672													10	10					0	0	0	0	A	64936610	A	A	64936610	2	1	273	1	0	0	0	0	0	0	0	1	2549	1219	43	4		4	CACHD1	1	64936610	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	12649423	64936610	184314011	10	49433											
AMY2B	280	broad.mit.edu	37	chr1	104115729	104115729	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attaatcatatgtctggtaaTgctgtgagtgcaggaacaag	13	12	11	5	0	2	1	1	1	1	0	2	2	2	2	0	2	3	3	0	2	5	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:104115729T>A	uc001duq.2	+	5	976	c.360T>A	c.(358-360)AAT>AAA	p.N120K	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.N120K|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	120					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TGTCTGGTAATGCTGTGAGTG	0.408													139	141					0	0	0	0	A	104115729	A	A	104115729	3	1	273	1	0	0	0	0	1	0	0	0	595	1461	51	5	370	5	AMY2B	1	104115729	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	39179119	104115729	145134892	11	49434											
BCL9	607	broad.mit.edu	37	chr1	147091317	147091317	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gttccaccttctatgaactcCcagtctgggaccataggacc	9	10	8	14	0	2	1	0	1	2	0	4	3	4	3	5	2	1	1	5	2	3	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:147091317C>T	uc001epq.2	+	8	2096	c.1356C>T	c.(1354-1356)TCC>TCT	p.S452S	BCL9_uc010ozr.1_Silent_p.S378S	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	452	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CTATGAACTCCCAGTCTGGGA	0.532			T	IGH@|IGL@	B-ALL								12	55					0	0	0	0	T	147091317	T	T	147091317	2	4	273	1	0	0	0	0	0	0	0	1	1383	610	22	4		4	BCL9	1	147091317	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	42975588	147091317	102159304	12	49435											
HIST2H3D	653604	broad.mit.edu	37	chr1	149785127	149785127	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gccggtagcggtgcggcttcTtcaccccgcccgtggccggc	2	7	15	17	6	2	0	1	0	1	0	2	0	2	0	5	5	2	2	5	5	1	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:149785127T>A	uc010pbl.1	-	1	110	c.110A>T	c.(109-111)AAG>ATG	p.K37M	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	37					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						GTGCGGCTTCTTCACCCCGCC	0.697													5	23					0	0	0	0	A	149785127	A	A	149785127	3	1	273	1	0	0	0	0	1	0	0	0	7220	1609	56	5	302	5	HIST2H3D	1	149785127	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	2693810	149785127	99465494	13	49436											
FLG	2312	broad.mit.edu	37	chr1	152276145	152276145	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgtctcgtgcctgctcGtggcgggatccttgtcttcc	2	13	13	13	3	2	0	0	0	2	0	6	2	4	1	3	2	3	2	3	2	0	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:152276145G>A	uc001ezu.1	-	3	11253	c.11217C>T	c.(11215-11217)CAC>CAT	p.H3739H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3739	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGCCTGCTCGTGGCGGGATC	0.602									Ichthyosis				16	363					0	0	0	0	A	152276145	A	A	152276145	2	1	273	1	0	0	0	0	0	0	0	1	5954	1136	40	1		1	FLG	1	152276145	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	2491018	152276145	96974476	14	49437											
FLG	2312	broad.mit.edu	37	chr1	152283117	152283117	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctgctgatggggcccagcTtgtccgtgggctgacactga	5	10	14	12	1	1	3	0	3	1	0	2	3	2	3	2	3	2	3	2	3	0	1	rs150981235		TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:152283117T>C	uc001ezu.1	-	3	4281	c.4245A>G	c.(4243-4245)CAA>CAG	p.Q1415Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1415	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGGCCCAGCTTGTCCGTGGG	0.562									Ichthyosis				10	247					0	0	0	0	C	152283117	C	C	152283117	2	2	273	1	0	0	0	0	0	0	0	1	5954	1606	56	5		5	FLG	1	152283117	Silent	SNP	T	TCGA-CX-7086-01A-11D-2078-08	6972	152283117	96967504	15	49438											
IQGAP3	128239	broad.mit.edu	37	chr1	156504953	156504953	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtggggagacaacacttGccttatagacctcgctgtct	8	10	13	10	1	1	2	0	0	1	2	2	3	1	2	2	4	2	1	2	4	3	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:156504953G>T	uc001fpf.2	-	28	3582	c.3507_splice	c.e28+1	p.K1169_splice		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3						small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GACAACACTTGCCTTATAGAC	0.507													27	108					5.09552e-08	5.72551e-08	1	0	T	156504953	T	T	156504953	5	4	273	1	0	0	0	0	0	0	1	0	7855	1333	46	4	1430	4	IQGAP3	1	156504953	Splice_Site	SNP	G	TCGA-CX-7086-01A-11D-2078-08	4221836	156504953	92745668	16	49439											
FCGR2A	2212	broad.mit.edu	37	chr1	161487824	161487824	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgaagaaaccaacaatgaCtatgaaacagctgacggcgg	16	6	10	9	2	0	5	0	4	0	1	0	5	0	5	1	2	4	1	1	2	6	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:161487824C>T	uc001gan.2	+	7	893	c.840C>T	c.(838-840)GAC>GAT	p.D280D	FCGR2A_uc001gam.2_Silent_p.D279D|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	280	Cytoplasmic (Potential).					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCAACAATGACTATGAAACAG	0.274													28	15					0	0	0	0	T	161487824	T	T	161487824	2	4	273	1	0	0	0	0	0	0	0	1	5813	564	20	4		4	FCGR2A	1	161487824	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	4982871	161487824	87762797	17	49440											
OLFML2B	25903	broad.mit.edu	37	chr1	161953788	161953788	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgctcaggacaatgacctCctggctgaagccctcatcgt	8	10	9	14	1	2	2	2	2	0	0	4	3	3	3	3	2	2	2	3	2	2	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:161953788C>A	uc001gbu.2	-	8	2354	c.1930G>T	c.(1930-1932)GAG>TAG	p.E644*	OLFML2B_uc001gbt.2_Nonsense_Mutation_p.E127*|OLFML2B_uc010pkq.1_Nonsense_Mutation_p.E645*	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	644	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			ACAATGACCTCCTGGCTGAAG	0.607													38	8					2.35968e-33	2.81522e-33	1	0	A	161953788	A	A	161953788	4	1	273	1	0	0	0	0	0	1	0	0	10912	864	30	2	326	2	OLFML2B	1	161953788	Nonsense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	465964	161953788	87296833	18	49441											
C1orf114	57821	broad.mit.edu	37	chr1	169364286	169364286	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatatttaatagaaactttCagttataatgatcagtaaaa	20	14	4	3	0	2	2	2	1	0	1	2	2	2	2	0	0	1	2	0	0	9	8			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:169364286C>T	uc001gga.1	-	6	1697	c.1529G>A	c.(1528-1530)TGA>TAA	p.*510*	BLZF1_uc001gfy.2_Intron|C1orf114_uc001gfz.1_Silent_p.*509*|C1orf114_uc009wvq.1_Silent_p.*509*	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	510											0	all_hematologic(923;0.208)					TAGAAACTTTCAGTTATAATG	0.348													15	25					0	0	0	0	T	169364286	T	T	169364286	2	4	273	1	0	0	0	0	0	0	0	1	1996	837	29	2		2	C1orf114	1	169364286	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	7410498	169364286	79886335	19	49442											
C1orf129	80133	broad.mit.edu	37	chr1	170967299	170967299	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttattctcttttacagaactCtcagtgaatataactttcca	12	17	3	9	0	2	2	1	1	2	1	5	2	3	2	1	0	3	0	1	0	6	7			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:170967299C>G	uc001ghg.2	+	15	1610	c.1480C>G	c.(1480-1482)CTC>GTC	p.L494V	C1orf129_uc009wvy.2_Missense_Mutation_p.L301V|C1orf129_uc010plz.1_Missense_Mutation_p.L494V	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	494							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTACAGAACTCTCAGTGAATA	0.398													37	32					0	0	0	0	G	170967299	G	G	170967299	3	3	273	1	0	0	0	0	1	0	0	0	2005	913	32	2	1534	2	C1orf129	1	170967299	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1603013	170967299	78283322	20	49443											
DNM3	26052	broad.mit.edu	37	chr1	172376929	172376929	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagccggagaccacccccatCaccaactcgtcccactataa	12	6	5	18	2	1	1	1	0	0	1	3	2	2	1	6	1	2	0	6	1	4	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:172376929C>A	uc001gie.2	+	21	2716	c.2540C>A	c.(2539-2541)TCA>TAA	p.S847*	DNM3_uc001gif.2_Nonsense_Mutation_p.S843*|DNM3_uc001gih.1_Intron|PIGC_uc001gii.1_Intron|PIGC_uc001gij.1_Intron	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	853					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						CCACCCCCATCACCAACTCGT	0.433													66	38					2.42712e-22	2.87349e-22	1	0	A	172376929	A	A	172376929	4	1	273	1	0	0	0	0	0	1	0	0	4695	838	29	2	2622	2	DNM3	1	172376929	Nonsense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1409630	172376929	76873692	21	49444											
SERPINC1	462	broad.mit.edu	37	chr1	173878987	173878987	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataacggaacttgccttcctGgtacatcatagatgctgaac	12	11	8	10	1	1	2	1	1	0	1	2	3	2	3	2	2	6	2	2	2	5	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:173878987G>T	uc001gjt.2	-	5	975	c.856C>A	c.(856-858)CAG>AAG	p.Q286K		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	286			Missing (in AT3D; type-I).		blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	TTGCCTTCCTGGTACATCATA	0.522													13	65					2.27111e-07	2.52436e-07	1	0	T	173878987	T	T	173878987	3	4	273	1	0	0	0	0	1	0	0	0	14174	1357	47	4	550	4	SERPINC1	1	173878987	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1502058	173878987	75371634	22	49445											
PPFIA4	8497	broad.mit.edu	37	chr1	203024771	203024771	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctcccgcagtgctgcccagGacctggaccgaatgggggtc	6	6	14	15	2	0	0	0	0	0	0	2	3	1	2	5	4	2	2	5	4	1	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:203024771G>A	uc001gyz.2	+	3	1116	c.523G>A	c.(523-525)GAC>AAC	p.D175N	PPFIA4_uc009xaj.2_Missense_Mutation_p.D806N|PPFIA4_uc010pqf.1_Missense_Mutation_p.D388N|PPFIA4_uc001gza.2_Missense_Mutation_p.D175N|PPFIA4_uc001gzb.1_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	175					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						TGCTGCCCAGGACCTGGACCG	0.657													9	43					0	0	0	0	A	203024771	A	A	203024771	3	1	273	1	0	0	0	0	1	0	0	0	12367	1174	41	2	533	2	PPFIA4	1	203024771	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	29145784	203024771	46225850	23	49446											
REN	5972	broad.mit.edu	37	chr1	204124947	204124947	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggggccgactcgaacctcaCctgaaatacatagtccgcgc	10	6	11	14	4	1	1	1	1	0	0	3	3	2	1	4	2	2	0	4	2	4	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:204124947C>A	uc001haq.2	-	9	1103	c.1059_splice	c.e9+1	p.Q353_splice		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein						angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	TCGAACCTCACCTGAAATACA	0.522													12	5					7.03913e-09	7.96736e-09	1	0	A	204124947	A	A	204124947	5	1	273	1	0	0	0	0	0	0	1	0	13289	521	18	4	168	4	REN	1	204124947	Splice_Site	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1100176	204124947	45125674	24	49447											
CR2	1380	broad.mit.edu	37	chr1	207639997	207639997	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcctcattggagaaaaaaGtctattatgcataactaaag	16	10	7	8	1	2	1	1	0	1	1	2	2	2	1	2	1	2	1	2	1	8	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:207639997G>A	uc001hfw.2	+	2	279	c.185G>A	c.(184-186)AGT>AAT	p.S62N	CR2_uc001hfv.2_Missense_Mutation_p.S62N|CR2_uc009xch.2_Missense_Mutation_p.S62N	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	62	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						GGAGAAAAAAGTCTATTATGC	0.398													24	91					0	0	0	0	A	207639997	A	A	207639997	3	1	273	1	0	0	0	0	1	0	0	0	3857	1029	36	4	191	4	CR2	1	207639997	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	3515050	207639997	41610624	25	49448											
URB2	9816	broad.mit.edu	37	chr1	229770966	229770966	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatgtgactgctcacctgctCcagccgtgcctggtcctgag	5	10	12	14	1	1	2	1	2	0	0	3	3	3	2	5	1	4	2	5	1	0	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:229770966C>T	uc001hts.1	+	4	742	c.606C>T	c.(604-606)CTC>CTT	p.L202L	URB2_uc009xfd.1_Silent_p.L202L	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	202						nucleolus				central_nervous_system(2)|ovary(1)	3						CTCACCTGCTCCAGCCGTGCC	0.607													8	61					0	0	0	0	T	229770966	T	T	229770966	2	4	273	1	0	0	0	0	0	0	0	1	17093	842	30	2		2	URB2	1	229770966	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	22130969	229770966	19479655	26	49449											
AHCTF1	25909	broad.mit.edu	37	chr1	247024567	247024567	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcacattttttaggtgtagTaaatacttctaatttgctat	11	19	6	5	0	1	0	0	0	1	0	1	0	1	0	0	1	3	4	0	1	7	10			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:247024567T>C	uc001ibu.1	-	28	3773	c.3766A>G	c.(3766-3768)ACT>GCT	p.T1256A	AHCTF1_uc001ibv.1_Missense_Mutation_p.T1265A|AHCTF1_uc009xgs.1_Missense_Mutation_p.T117A|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1256	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTAGGTGTAGTAAATACTTCT	0.363													9	5					0	0	0	0	C	247024567	C	C	247024567	3	2	273	1	0	0	0	0	1	0	0	0	408	1638	57	5	3066	5	AHCTF1	1	247024567	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	17253601	247024567	2226054	27	49450											
OR2T12	127064	broad.mit.edu	37	chr1	248458195	248458195	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggccttcttgcgggcttctGtagagcgcatgagcagaaca	9	9	13	10	2	2	3	0	1	2	2	2	3	2	3	1	2	4	4	1	2	2	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr1:248458195G>T	uc010pzj.1	-	1	686	c.686C>A	c.(685-687)ACA>AAA	p.T229K		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GCGGGCTTCTGTAGAGCGCAT	0.517													16	60					2.35188e-11	2.7016e-11	1	0	T	248458195	T	T	248458195	3	4	273	1	0	0	0	0	1	0	0	0	11073	1377	48	4	279	4	OR2T12	1	248458195	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1433628	248458195	792426	28	49451											
IAH1	285148	broad.mit.edu	37	chr2	9624665	9624666	+	Frame_Shift_Ins	INS	-	T	T																															acttgacctgtggaccctgaINStgcaggacagccaggtacgg																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr2:9624665_9624666insT	uc002qzr.2	+	5	576_577	c.550_551insT	c.(550-552)ATGfs	p.M184fs	IAH1_uc002qzs.2_Frame_Shift_Ins_p.M71fs|IAH1_uc002qzt.2_Frame_Shift_Ins_p.M71fs|IAH1_uc010yiz.1_RNA	NM_001039613	NP_001034702	Q2TAA2	IAH1_HUMAN	isoamyl acetate-hydrolyzing esterase 1 homolog	184					lipid catabolic process		hydrolase activity, acting on ester bonds				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTGGACCCTGATGCAGGACAGC	0.515													---	---	---								T	9624666	T	T	9624665	7	5	273	1	0	1	1	0	0	0	0	0	7510	333	12	0	568	0	IAH1	2	9624665	Frame_Shift_Ins	INS	-	TCGA-CX-7086-01A-11D-2078-08		9624665	233574708	29	49452											
LPIN1	23175	broad.mit.edu	37	chr2	11911611	11911611	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgagaggcctggaccccagCacgccagcccaagtgatcgc	10	4	12	15	2	0	2	0	2	0	1	1	4	0	3	5	2	2	1	5	2	1	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr2:11911611C>T	uc010yjn.1	+	5	676	c.402C>T	c.(400-402)AGC>AGT	p.S134S	LPIN1_uc010yjm.1_Silent_p.S183S|LPIN1_uc002rbt.2_Silent_p.S134S|LPIN1_uc002rbs.2_Silent_p.S134S	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	134					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		TGGACCCCAGCACGCCAGCCC	0.572													3	24					0	0	0	0	T	11911611	T	T	11911611	2	4	273	1	0	0	0	0	0	0	0	1	8968	709	25	4		4	LPIN1	2	11911611	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	2286946	11911611	231287762	30	49453											
NRXN1	9378	broad.mit.edu	37	chr2	50318511	50318511	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtccacctgcaacgtggcaTtgccaccactcctcgtgaaa	9	9	8	15	2	0	1	0	1	0	0	3	1	2	1	5	1	3	2	5	1	2	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr2:50318511T>A	uc010fbp.2	-	3	1370	c.563A>T	c.(562-564)AAT>ATT	p.N188I	NRXN1_uc002rxb.3_Missense_Mutation_p.N895I|NRXN1_uc010fbq.2_Missense_Mutation_p.N1263I|NRXN1_uc002rxe.3_Missense_Mutation_p.N1223I	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	188	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CAACGTGGCATTGCCACCACT	0.453													25	128					0	0	0	0	A	50318511	A	A	50318511	3	1	273	1	0	0	0	0	1	0	0	0	10719	1493	52	5	875	5	NRXN1	2	50318511	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	38406900	50318511	192880862	31	49454											
SPTBN1	6711	broad.mit.edu	37	chr2	54859772	54859772	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcagcaattaaaaagcaaGaggacttcatgaccaccatg	18	6	8	9	0	1	2	1	1	0	1	1	3	1	3	2	1	3	3	2	1	6	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr2:54859772G>C	uc002rxu.2	+	17	3883	c.3634G>C	c.(3634-3636)GAG>CAG	p.E1212Q	SPTBN1_uc002rxx.2_Missense_Mutation_p.E1199Q	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1212	Spectrin 9.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			TAAAAAGCAAGAGGACTTCAT	0.478													6	39					0	0	0	0	C	54859772	C	C	54859772	3	2	273	1	0	0	0	0	1	0	0	0	15185	943	33	2	3809	2	SPTBN1	2	54859772	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	4541261	54859772	188339601	32	49455											
BCL11A	53335	broad.mit.edu	37	chr2	60687943	60687943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccgtccagctccccgggcgGtgtggagaagcgcaaactcc	7	6	13	15	4	0	1	0	0	0	1	4	2	4	1	5	3	3	2	5	3	2	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr2:60687943G>A	uc002sae.1	-	4	2332	c.2104C>T	c.(2104-2106)CCG>TCG	p.P702S	BCL11A_uc002sab.2_Missense_Mutation_p.P702S|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.P371S|BCL11A_uc010ypj.1_Missense_Mutation_p.P668S|BCL11A_uc002sad.1_Missense_Mutation_p.P550S|BCL11A_uc002saf.1_Missense_Mutation_p.P668S	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	702					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TCCCCGGGCGGTGTGGAGAAG	0.652			T	IGH@	B-CLL								13	31					0	0	0	0	A	60687943	A	A	60687943	3	1	273	1	0	0	0	0	1	0	0	0	1365	1261	44	4	513	4	BCL11A	2	60687943	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	5828171	60687943	182511430	33	49456											
MBD5	55777	broad.mit.edu	37	chr2	149247498	149247498	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccaaaaaacagtgggacgggGagcaaagccccagaggggag	15	1	16	9	1	0	1	0	0	0	1	0	4	0	4	3	5	3	1	3	5	4	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr2:149247498G>A	uc002twm.3	+	12	4586	c.3598G>A	c.(3598-3600)GAG>AAG	p.E1200K	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Missense_Mutation_p.E1200K|MBD5_uc002two.2_Missense_Mutation_p.E458K|MBD5_uc002twp.2_Missense_Mutation_p.E250K	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1200						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GTGGGACGGGGAGCAAAGCCC	0.473													5	81					0	0	0	0	A	149247498	A	A	149247498	3	1	273	1	0	0	0	0	1	0	0	0	9400	1175	41	2	3624	2	MBD5	2	149247498	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	88559555	149247498	93951875	34	49457											
TTN	7273	broad.mit.edu	37	chr2	179598082	179598082	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atttgagctgggcaacattgTttttaaaacttattcggtat	11	17	8	5	1	0	1	0	1	0	0	1	1	0	1	0	2	3	4	0	2	5	8			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr2:179598082T>A	uc010zfg.1	-	51	12430	c.12206A>T	c.(12205-12207)AAC>ATC	p.N4069I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.N730I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4996							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCAACATTGTTTTTAAAACT	0.463													26	41					0	0	0	0	A	179598082	A	A	179598082	3	1	273	1	0	0	0	0	1	0	0	0	16803	1725	60	5	88827	5	TTN	2	179598082	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	30350584	179598082	63601291	35	49458											
PIKFYVE	200576	broad.mit.edu	37	chr2	209191008	209191008	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggccgattatcgagccaGaggaggaagaattcagccca	12	6	13	10	2	1	2	1	0	0	2	2	6	1	4	3	3	2	1	3	3	3	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr2:209191008G>T	uc002vcz.2	+	20	3631	c.3473G>T	c.(3472-3474)AGA>ATA	p.R1158I	PIKFYVE_uc010fun.1_Missense_Mutation_p.R839I|PIKFYVE_uc002vcy.1_Missense_Mutation_p.R1102I	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1158					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TATCGAGCCAGAGGAGGAAGA	0.463													8	31					0.00307968	0.00319336	1	0	T	209191008	T	T	209191008	3	4	273	1	0	0	0	0	1	0	0	0	11979	942	33	2	3558	2	PIKFYVE	2	209191008	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	29592926	209191008	34008365	36	49459											
PIKFYVE	200576	broad.mit.edu	37	chr2	209191022	209191022	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagccagaggaggaagaattCagcccaaaaattcagaccct	16	5	10	10	0	2	3	2	0	0	3	2	6	2	5	3	2	2	0	3	2	4	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr2:209191022C>T	uc002vcz.2	+	20	3645	c.3487C>T	c.(3487-3489)CAG>TAG	p.Q1163*	PIKFYVE_uc010fun.1_Nonsense_Mutation_p.Q844*|PIKFYVE_uc002vcy.1_Nonsense_Mutation_p.Q1107*	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1163					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						AGGAAGAATTCAGCCCAAAAA	0.478													9	31					0	0	0	0	T	209191022	T	T	209191022	4	4	273	1	0	0	0	0	0	1	0	0	11979	827	29	2	3572	2	PIKFYVE	2	209191022	Nonsense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	14	209191022	34008351	37	49460											
FARP2	9855	broad.mit.edu	37	chr2	242415337	242415337	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctcatccggctggagaacCtgcagaagctaacggagctg	10	8	12	11	2	1	2	1	0	1	2	3	4	2	3	2	3	5	4	2	3	3	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr2:242415337C>T	uc002wbi.1	+	19	2314	c.2197C>T	c.(2197-2199)CTG>TTG	p.L733L	hsa-mir-3133|MI0014153_5'Flank	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	733					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GCTGGAGAACCTGCAGAAGCT	0.557													9	26					0	0	0	0	T	242415337	T	T	242415337	2	4	273	1	0	0	0	0	0	0	0	1	5709	680	24	4		4	FARP2	2	242415337	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	33224315	242415337	784036	38	49461											
ATRIP	84126	broad.mit.edu	37	chr3	48505262	48505262	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accacgaccagctggcacctCagctctgttcccactcaggt	8	8	8	17	1	3	0	2	0	1	0	4	1	4	0	4	2	2	4	4	2	0	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:48505262C>T	uc003ctf.1	+	9	1896	c.1864C>T	c.(1864-1866)CAG>TAG	p.Q622*	ATRIP_uc011bbj.1_Nonsense_Mutation_p.Q495*|ATRIP_uc003ctg.1_Nonsense_Mutation_p.Q622*|TREX1_uc010hjy.2_5'UTR|TREX1_uc003ctj.2_5'Flank|TREX1_uc003ctk.2_5'Flank|TREX1_uc010hjz.2_5'Flank|TREX1_uc010hka.2_5'Flank	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	622					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCTGGCACCTCAGCTCTGTTC	0.627								Other_conserved_DNA_damage_response_genes					5	26					0	0	0	0	T	48505262	T	T	48505262	4	4	273	1	0	0	0	0	0	1	0	0	1207	827	29	2	1898	2	ATRIP	3	48505262	Nonsense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08		48505262	149517168	39	49462											
HYAL2	8692	broad.mit.edu	37	chr3	50357479	50357479	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaccggcgatacacatcttTgtcctgccagttgcgcaccc	8	10	8	15	3	1	0	0	0	1	0	2	1	2	0	4	1	4	2	4	1	2	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:50357479T>C	uc003czu.2	-	2	662	c.442A>G	c.(442-444)AAA>GAA	p.K148E	HYAL2_uc003czx.2_Missense_Mutation_p.K148E|HYAL2_uc003czv.2_Missense_Mutation_p.K148E|HYAL2_uc003czw.2_Missense_Mutation_p.K148E|HYAL2_uc010hlj.2_Missense_Mutation_p.K148E	NM_033158	NP_149348	Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2 precursor	148						anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	TACACATCTTTGTCCTGCCAG	0.572													36	15					0	0	0	0	C	50357479	C	C	50357479	3	2	273	1	0	0	0	0	1	0	0	0	7503	1821	63	5	991	5	HYAL2	3	50357479	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	1852217	50357479	147664951	40	49463											
VPRBP	9730	broad.mit.edu	37	chr3	51450829	51450829	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	taagtcatcttcatcatctgCctgcaacatagcttgagggg	10	12	9	10	0	5	1	3	1	2	0	5	1	5	1	1	2	4	2	1	2	3	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:51450829C>T	uc003dbe.1	-	20	4111	c.3943G>A	c.(3943-3945)GCA>ACA	p.A1315T	VPRBP_uc003dbf.1_Missense_Mutation_p.A591T	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	1315					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		TCATCATCTGCCTGCAACATA	0.433													5	8					0	0	0	0	T	51450829	T	T	51450829	3	4	273	1	0	0	0	0	1	0	0	0	17253	739	26	4	600	4	VPRBP	3	51450829	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1093350	51450829	146571601	41	49464											
CACNA2D3	55799	broad.mit.edu	37	chr3	54420765	54420765	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctggtggaggctgcagaagaAgcacacctgaaacatgaatt	14	7	12	8	0	0	4	0	2	0	2	0	5	0	5	1	3	3	3	1	3	4	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:54420765A>T	uc003dhf.2	+	4	393	c.345A>T	c.(343-345)GAA>GAT	p.E115D	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.E21D|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Translation_Start_Site	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	115	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CTGCAGAAGAAGCACACCTGA	0.393													4	0					0	0	0	0	T	54420765	T	T	54420765	3	4	273	1	0	0	0	0	1	0	0	0	2562	69	3	5	359	5	CACNA2D3	3	54420765	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	2969936	54420765	143601665	42	49465											
ALCAM	214	broad.mit.edu	37	chr3	105258904	105258904	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atcactcttaaatgcttaggGaatggcaaccctcccccaga	12	9	7	13	0	2	1	1	0	1	1	3	2	3	2	3	2	2	2	3	2	5	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:105258904G>A	uc003dvx.2	+	7	1356	c.816G>A	c.(814-816)GGG>GGA	p.G272G	ALCAM_uc003dvw.1_Silent_p.G272G|ALCAM_uc003dvy.2_Silent_p.G272G|ALCAM_uc011bhh.1_Silent_p.G221G|ALCAM_uc010hpp.2_Intron	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	272	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						AATGCTTAGGGAATGGCAACC	0.398													21	107					0	0	0	0	A	105258904	A	A	105258904	2	1	273	1	0	0	0	0	0	0	0	1	487	1161	41	2		2	ALCAM	3	105258904	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	50838139	105258904	92763526	43	49466											
BOC	91653	broad.mit.edu	37	chr3	112968723	112968723	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttgcctcctcctagccaCagcaggctgctttgctgact	5	11	10	15	0	0	1	0	1	0	0	2	1	2	1	4	2	5	5	4	2	1	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:112968723C>A	uc003dzx.2	+	3	695	c.74C>A	c.(73-75)ACA>AAA	p.T25K	BOC_uc010hqi.2_Missense_Mutation_p.T25K|BOC_uc003dzy.2_Missense_Mutation_p.T25K|BOC_uc003dzz.2_Missense_Mutation_p.T25K|BOC_uc003dzw.1_Missense_Mutation_p.T25K|BOC_uc003eaa.1_Missense_Mutation_p.T25K	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	25					cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			CTCCTAGCCACAGCAGGCTGC	0.507													6	23					3.59834e-05	3.84736e-05	1	0	A	112968723	A	A	112968723	3	1	273	1	0	0	0	0	1	0	0	0	1484	478	17	4	76	4	BOC	3	112968723	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	7709819	112968723	85053707	44	49467											
GPR156	165829	broad.mit.edu	37	chr3	119912164	119912164	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatgagagtttccattgagCtccccactaaaacatcctga	13	10	7	11	0	0	3	0	3	0	1	3	5	3	3	4	0	2	2	4	0	3	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:119912164C>T	uc011bjf.1	-	3	341	c.341G>A	c.(340-342)AGC>AAC	p.S114N	GPR156_uc011bjg.1_Missense_Mutation_p.S114N	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	114	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		TTCCATTGAGCTCCCCACTAA	0.413													27	44					0	0	0	0	T	119912164	T	T	119912164	3	4	273	1	0	0	0	0	1	0	0	0	6699	797	28	4	2131	4	GPR156	3	119912164	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	6943441	119912164	78110266	45	49468											
STXBP5L	9515	broad.mit.edu	37	chr3	120998727	120998727	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactgttaagcatggggacCattgacctatatagatcaag	13	11	10	7	0	1	2	1	1	0	1	1	3	1	3	2	2	2	3	2	2	6	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:120998727C>T	uc003eec.3	+	19	2174	c.2034C>T	c.(2032-2034)ACC>ACT	p.T678T	STXBP5L_uc011bji.1_Silent_p.T678T	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	678	WD 10.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GCATGGGGACCATTGACCTAT	0.398													42	55					0	0	0	0	T	120998727	T	T	120998727	2	4	273	1	0	0	0	0	0	0	0	1	15423	581	21	4		4	STXBP5L	3	120998727	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1086563	120998727	77023703	46	49469											
CASR	846	broad.mit.edu	37	chr3	122003858	122003858	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttactcccgctgcagtgcggGgaaacggacttagatctgac	9	9	12	11	3	1	2	0	1	1	1	2	4	2	4	1	3	4	2	1	3	3	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:122003858G>A	uc003eev.3	+	7	3429	c.3057G>A	c.(3055-3057)GGG>GGA	p.G1019G	CASR_uc003eew.3_Silent_p.G1029G	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	1019	Cytoplasmic (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGCAGTGCGGGGAAACGGACT	0.602													13	58					0	0	0	0	A	122003858	A	A	122003858	2	1	273	1	0	0	0	0	0	0	0	1	2694	1219	43	4		4	CASR	3	122003858	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1005131	122003858	76018572	47	49470											
SEMA5B	54437	broad.mit.edu	37	chr3	122629889	122629889	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaccaagtggatgagattgAaccctaggggaagagaggca	14	5	14	8	0	0	3	0	2	0	2	0	7	0	5	3	4	1	1	3	4	4	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:122629889A>T	uc003efz.1	-	22	3399	c.3095T>A	c.(3094-3096)TTC>TAC	p.F1032Y	SEMA5B_uc011bju.1_Missense_Mutation_p.F938Y|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.F1032Y|SEMA5B_uc003efy.1_Missense_Mutation_p.F10Y	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	1032	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		GATGAGATTGAACCCTAGGGG	0.587													11	14					0	0	0	0	T	122629889	T	T	122629889	3	4	273	1	0	0	0	0	1	0	0	0	14103	246	9	5	368	5	SEMA5B	3	122629889	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	626031	122629889	75392541	48	49471											
KALRN	8997	broad.mit.edu	37	chr3	124413262	124413262	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtgcaaagtctgtgggCggccaaagcccaccatcact	10	7	11	13	1	2	0	1	0	1	0	2	0	2	0	3	2	3	2	3	2	2	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:124413262C>T	uc003ehg.2	+	53	7616	c.7489C>T	c.(7489-7491)CGG>TGG	p.R2497W	KALRN_uc003ehk.2_Missense_Mutation_p.R800W	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2496	Ig-like C2-type.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AGTCTGTGGGCGGCCAAAGCC	0.527													42	58					0	0	0	0	T	124413262	T	T	124413262	3	4	273	1	0	0	0	0	1	0	0	0	8014	759	27	1	7855	1	KALRN	3	124413262	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1783373	124413262	73609168	49	49472											
PLXND1	23129	broad.mit.edu	37	chr3	129293182	129293182	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccactgggcatgcttaccgcGtggatctcgggggcggggca	5	7	17	12	4	1	0	0	0	1	0	2	1	1	1	2	6	2	3	2	6	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:129293182G>A	uc003emx.2	-	12	2782	c.2682C>T	c.(2680-2682)CGC>CGT	p.R894R		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	894	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGCTTACCGCGTGGATCTCGG	0.701													3	11					0	0	0	0	A	129293182	A	A	129293182	2	1	273	1	0	0	0	0	0	0	0	1	12182	1136	40	1		1	PLXND1	3	129293182	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	4879920	129293182	68729248	50	49473											
COL6A6	131873	broad.mit.edu	37	chr3	130289961	130289961	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcagaccacatgttcactGaagcccggggcagccgcctg	8	7	11	15	2	2	2	2	1	1	1	3	2	2	2	4	2	2	2	4	2	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:130289961G>A	uc010htl.2	+	6	2732	c.2701G>A	c.(2701-2703)GAA>AAA	p.E901K		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	901	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CATGTTCACTGAAGCCCGGGG	0.532													10	18					0	0	0	0	A	130289961	A	A	130289961	3	1	273	1	0	0	0	0	1	0	0	0	3718	1291	45	2	2723	2	COL6A6	3	130289961	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	996779	130289961	67732469	51	49474											
ASTE1	28990	broad.mit.edu	37	chr3	130743229	130743229	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agtaccacactggaagaagtCctgtagcttcacctgggact	11	9	10	11	0	1	1	1	0	0	1	2	3	2	3	3	2	2	3	3	2	4	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:130743229C>G	uc003env.1	-	3	1364	c.922G>C	c.(922-924)GAC>CAC	p.D308H	NEK11_uc003enx.2_5'Flank|NEK11_uc003eny.2_5'Flank|NEK11_uc003eoa.2_5'Flank|NEK11_uc003enz.2_5'Flank|NEK11_uc010htn.2_5'Flank|NEK11_uc011blk.1_5'Flank|NEK11_uc011bll.1_5'Flank|NEK11_uc003enw.1_5'Flank|NEK11_uc011blm.1_5'Flank|ASTE1_uc010htm.1_Missense_Mutation_p.D308H|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	308					DNA repair		nuclease activity				0						TGGAAGAAGTCCTGTAGCTTC	0.423													7	79					0	0	0	0	G	130743229	G	G	130743229	3	3	273	1	0	0	0	0	1	0	0	0	1064	855	30	2	1133	2	ASTE1	3	130743229	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	453268	130743229	67279201	52	49475											
PLSCR4	57088	broad.mit.edu	37	chr3	145917612	145917612	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctgacctcttgtctggcAgaggggcaacagaagcaaca	11	8	11	11	0	3	3	0	1	3	2	4	3	3	3	1	3	3	3	1	3	3	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:145917612A>G	uc010huy.2	-	6	941	c.612T>C	c.(610-612)TCT>TCC	p.S204S	PLSCR4_uc010huz.2_Silent_p.S204S|PLSCR4_uc003evt.3_Silent_p.S204S|PLSCR4_uc010hva.2_Intron|PLSCR4_uc003evu.3_Intron	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	204	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						CTTGTCTGGCAGAGGGGCAAC	0.502													6	17					0	0	0	0	G	145917612	G	G	145917612	2	3	273	1	0	0	0	0	0	0	0	1	12167	175	7	5		5	PLSCR4	3	145917612	Silent	SNP	A	TCGA-CX-7086-01A-11D-2078-08	15174383	145917612	52104818	53	49476											
IFT80	57560	broad.mit.edu	37	chr3	160095241	160095241	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taactaatgctgttccttcaTaattccatcttcctgcaagt	10	16	4	11	0	2	0	1	0	1	0	5	0	5	0	3	0	3	3	3	0	4	7			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:160095241T>C	uc011boy.1	-	4	780	c.347A>G	c.(346-348)TAT>TGT	p.Y116C	IFT80_uc003fda.2_Intron|IFT80_uc003fdb.1_5'UTR|IFT80_uc003fdd.1_5'UTR|IFT80_uc003fde.1_5'UTR	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	116	WD 2.					cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TGTTCCTTCATAATTCCATCT	0.308													10	61					0	0	0	0	C	160095241	C	C	160095241	3	2	273	1	0	0	0	0	1	0	0	0	7603	1406	49	5	2054	5	IFT80	3	160095241	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	14177629	160095241	37927189	54	49477											
PEX5L	51555	broad.mit.edu	37	chr3	179525537	179525538	+	Missense_Mutation	DNP	GC	TT	TT																															atcctggctgaatctccagtGctcgcgtataggcctccacg																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:179525537_179525538GC>TT	uc003fki.1	-	14	1730_1731	c.1600_1601GC>AA	c.(1600-1602)GCA>AAA	p.A534K	PEX5L_uc011bqd.1_Missense_Mutation_p.A491K|PEX5L_uc011bqe.1_Missense_Mutation_p.A342K|PEX5L_uc011bqf.1_Missense_Mutation_p.A426K|PEX5L_uc003fkj.1_Missense_Mutation_p.A499K|PEX5L_uc010hxd.1_Missense_Mutation_p.A532K|PEX5L_uc011bqg.1_Missense_Mutation_p.A510K|PEX5L_uc011bqh.1_Missense_Mutation_p.A475K	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	534	TPR 4.				protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			AATCTCCAGTGCTCGCGTATAG	0.554													63	108					0	0	0	0	TT	179525538	TT	TT	179525537	3	4	273	1	0	0	0	0	1	0	0	0	11804	1319	46	4	287	4	PEX5L	3	179525537	Missense_Mutation	DNP	GC	TCGA-CX-7086-01A-11D-2078-08	19430296	179525537	18496893	55	49478											
PARL	55486	broad.mit.edu	37	chr3	183560190	183560190	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttgctgccatgtgaaataagGagaaatgactgaatgttgac	14	11	11	5	0	0	5	0	4	0	1	0	6	0	5	1	1	2	2	1	1	4	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:183560190G>A	uc003fmd.2	-	6	712	c.653C>T	c.(652-654)TCC>TTC	p.S218F	PARL_uc003fme.2_Intron	NM_018622	NP_061092	Q9H300	PARL_HUMAN	presenilin associated, rhomboid-like isoform 1	218	Helical; (Potential).				proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity				0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GTGAAATAAGGAGAAATGACT	0.398													21	87					0	0	0	0	A	183560190	A	A	183560190	3	1	273	1	0	0	0	0	1	0	0	0	11505	1174	41	2	506	2	PARL	3	183560190	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	4034653	183560190	14462240	56	49479											
VPS8	23355	broad.mit.edu	37	chr3	184567769	184567769	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaaacttctaagatcaataAcagatgctcatcctccagga	16	9	6	10	0	3	2	2	0	1	2	5	4	5	3	2	1	3	1	2	1	5	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr3:184567769A>G	uc003fpb.1	+	9	877	c.706A>G	c.(706-708)ACA>GCA	p.T236A	VPS8_uc010hyd.1_Missense_Mutation_p.T236A	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	238							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			AAGATCAATAACAGATGCTCA	0.313													8	46					0	0	0	0	G	184567769	G	G	184567769	3	3	273	1	0	0	0	0	1	0	0	0	17286	43	2	5	742	5	VPS8	3	184567769	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	1007579	184567769	13454661	57	49480											
HTT	3064	broad.mit.edu	37	chr4	3225795	3225795	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtttcaaagagagagaatAttgccacccatcatttatat	14	13	7	7	0	2	2	2	0	0	2	2	4	2	2	2	1	1	1	2	1	5	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:3225795A>G	uc011bvq.1	+	57	7853	c.7708A>G	c.(7708-7710)ATT>GTT	p.I2570V		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2568					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GAGAGAGAATATTGCCACCCA	0.468													22	82					0	0	0	0	G	3225795	G	G	3225795	3	3	273	1	0	0	0	0	1	0	0	0	7496	449	16	5	7924	5	HTT	4	3225795	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08		3225795	187928481	58	49481											
STIM2	57620	broad.mit.edu	37	chr4	27004653	27004653	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcaaaggaggaggcttgtcGgctgagagagctaagggagg	11	6	19	5	1	0	2	0	1	0	1	1	6	0	5	0	6	2	4	0	6	2	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:27004653G>A	uc003gsh.3	+	7	1385	c.1169G>A	c.(1168-1170)CGG>CAG	p.R390Q	STIM2_uc003gsg.3_Missense_Mutation_p.R390Q|STIM2_uc010iex.2_Missense_Mutation_p.R390Q|STIM2_uc010iey.2_Missense_Mutation_p.R14Q	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	303	Cytoplasmic (Potential).|Potential.				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				GAGGCTTGTCGGCTGAGAGAG	0.388													13	28					0	0	0	0	A	27004653	A	A	27004653	3	1	273	1	0	0	0	0	1	0	0	0	15350	1116	39	1	934	1	STIM2	4	27004653	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	23778858	27004653	164149623	59	49482											
COMMD8	54951	broad.mit.edu	37	chr4	47458656	47458656	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaactatttctcttgacaGagcctgtttgatttcatctt	9	17	6	9	0	3	3	1	2	2	1	4	3	3	3	1	0	3	2	1	0	2	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:47458656G>C	uc003gxi.2	-	3	321	c.313C>G	c.(313-315)CTG>GTG	p.L105V		NM_017845	NP_060315	Q9NX08	COMD8_HUMAN	COMM domain containing 8	105							protein binding				0						TCTCTTGACAGAGCCTGTTTG	0.328													19	82					0	0	0	0	C	47458656	C	C	47458656	3	2	273	1	0	0	0	0	1	0	0	0	3737	933	33	2	250	2	COMMD8	4	47458656	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	20454003	47458656	143695620	60	49483											
SLC10A4	201780	broad.mit.edu	37	chr4	48487038	48487038	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcttggatcaacacccCtatcgtgcagttactacccc	8	10	8	15	1	1	0	1	0	0	0	2	1	1	1	4	2	4	3	4	2	4	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:48487038C>A	uc003gyc.2	+	2	899	c.680C>A	c.(679-681)CCT>CAT	p.P227H		NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	227	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1						ATCAACACCCCTATCGTGCAG	0.552													62	126					6.26901e-30	7.45048e-30	1	0	A	48487038	A	A	48487038	3	1	273	1	0	0	0	0	1	0	0	0	14441	681	24	4	686	4	SLC10A4	4	48487038	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1028382	48487038	142667238	61	49484											
LRRC66	339977	broad.mit.edu	37	chr4	52861475	52861475	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtctaattcattggaatcAtaacggcttgagccagagac	12	10	11	8	1	3	2	2	1	1	1	3	4	3	3	1	3	2	1	1	3	3	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:52861475A>G	uc003gzi.2	-	4	1726	c.1713T>C	c.(1711-1713)TAT>TAC	p.Y571Y		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	571						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CATTGGAATCATAACGGCTTG	0.498													23	92					0	0	0	0	G	52861475	G	G	52861475	2	3	273	1	0	0	0	0	0	0	0	1	9068	224	8	5		5	LRRC66	4	52861475	Silent	SNP	A	TCGA-CX-7086-01A-11D-2078-08	4374437	52861475	138292801	62	49485											
SCARB2	950	broad.mit.edu	37	chr4	77116980	77116980	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcagagggggcttctcccagGagtcaaatgcctcagtacca	10	7	12	12	0	3	1	2	0	1	1	4	2	3	2	3	3	2	3	3	3	2	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:77116980G>A	uc003hju.1	-	2	494	c.155C>T	c.(154-156)TCC>TTC	p.S52F	SCARB2_uc011cbu.1_Missense_Mutation_p.S52F	NM_005506	NP_005497	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	52	Lumenal (Potential).				cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity				0			Lung(101;0.196)			CTTCTCCCAGGAGTCAAATGC	0.438													25	35					0	0	0	0	A	77116980	A	A	77116980	3	1	273	1	0	0	0	0	1	0	0	0	13947	1174	41	2	1325	2	SCARB2	4	77116980	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	24255505	77116980	114037296	63	49486											
CCDC158	339965	broad.mit.edu	37	chr4	77300534	77300534	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagctgacgcatatacataGagttttggtttcttgcttgc	8	16	10	7	1	1	3	0	2	1	1	1	3	1	3	0	1	4	5	0	1	3	8			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:77300534G>A	uc003hkb.3	-	8	1091	c.938C>T	c.(937-939)TCT>TTT	p.S313F	CCDC158_uc003hkd.2_Missense_Mutation_p.S313F	NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	313	Potential.									skin(3)|ovary(2)|pancreas(1)	6						CATATACATAGAGTTTTGGTT	0.383													10	41					0	0	0	0	A	77300534	A	A	77300534	3	1	273	1	0	0	0	0	1	0	0	0	2803	942	33	2	2471	2	CCDC158	4	77300534	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	183554	77300534	113853742	64	49487											
CCNG2	901	broad.mit.edu	37	chr4	78081922	78081923	+	Missense_Mutation	DNP	GC	TT	TT																															gagtctgttcttttttgctgGctgctagaatagttgaagaa																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:78081922_78081923GC>TT	uc003hkq.3	+	4	628_629	c.325_326GC>TT	c.(325-327)GCT>TTT	p.A109F	CCNG2_uc003hkn.3_Missense_Mutation_p.A109F|CCNG2_uc011ccc.1_Missense_Mutation_p.A109F|CCNG2_uc003hkp.3_Missense_Mutation_p.A109F	NM_004354	NP_004345	Q16589	CCNG2_HUMAN	cyclin G2	109					cell cycle checkpoint|cell division|mitosis	cytoplasm				ovary(2)|lung(1)	3						TTTTTTGCTGGCTGCTAGAATA	0.386													41	78					0	0	0	0	TT	78081923	TT	TT	78081922	3	4	273	1	0	0	0	0	1	0	0	0	2939	1203	42	4	335	4	CCNG2	4	78081922	Missense_Mutation	DNP	GC	TCGA-CX-7086-01A-11D-2078-08	781388	78081922	113072354	65	49488											
TACR3	6870	broad.mit.edu	37	chr4	104640669	104640669	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggcagtcccagcgcggaaGgggaggaggagaggttgcca	10	3	19	9	2	0	1	0	0	0	1	1	5	1	4	2	7	2	2	2	7	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:104640669G>A	uc003hxe.1	-	1	307	c.164C>T	c.(163-165)CCT>CTT	p.P55L		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	55	Extracellular (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		CAGCGCGGAAGGGGAGGAGGA	0.697													7	36					0	0	0	0	A	104640669	A	A	104640669	3	1	273	1	0	0	0	0	1	0	0	0	15573	1000	35	4	1253	4	TACR3	4	104640669	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	26558747	104640669	86513607	66	49489											
TIGD4	201798	broad.mit.edu	37	chr4	153691231	153691231	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacatttggaagataaacatGatggaaagaatgctaactca	18	10	8	5	0	1	3	1	1	0	2	1	5	1	5	0	2	4	1	0	2	7	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:153691231G>A	uc003imy.2	-	2	1708	c.926C>T	c.(925-927)TCA>TTA	p.S309L		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	309	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					AGATAAACATGATGGAAAGAA	0.343													6	46					0	0	0	0	A	153691231	A	A	153691231	3	1	273	1	0	0	0	0	1	0	0	0	15964	1294	45	2	616	2	TIGD4	4	153691231	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	49050562	153691231	37463045	67	49490											
FGG	2266	broad.mit.edu	37	chr4	155528082	155528082	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcgaagtaggcatatgttaGgcggtacttgtcagcttcag	10	11	13	7	2	2	0	2	0	0	0	2	1	2	0	0	3	3	5	0	3	5	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:155528082G>T	uc003ioj.2	-	8	1045	c.904C>A	c.(904-906)CTA>ATA	p.L302I	FGG_uc003iog.2_Missense_Mutation_p.L302I|FGG_uc003ioh.2_Missense_Mutation_p.L310I|FGG_uc010ipx.2_Missense_Mutation_p.L130I|FGG_uc010ipy.2_Missense_Mutation_p.L13I|FGG_uc003ioi.2_Missense_Mutation_p.L13I|FGG_uc003iok.2_Missense_Mutation_p.L310I	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	302	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GCATATGTTAGGCGGTACTTG	0.478													9	55					1.76689e-08	1.99259e-08	1	0	T	155528082	T	T	155528082	3	4	273	1	0	0	0	0	1	0	0	0	5902	991	35	4	484	4	FGG	4	155528082	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1836851	155528082	35626194	68	49491											
KIAA1712	80817	broad.mit.edu	37	chr4	175229984	175229984	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	taaagatgcctgaagtaaagGttcctgaaatcaaggctgag	15	9	11	6	0	1	4	1	3	0	1	2	4	2	4	2	2	1	3	2	2	7	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr4:175229984G>A	uc003itr.2	+	7	1066	c.652G>A	c.(652-654)GTT>ATT	p.V218I	KIAA1712_uc010iro.2_Missense_Mutation_p.V218I|KIAA1712_uc003its.2_RNA	NM_001040157	NP_001035247	Q9C0F1	CEP44_HUMAN	HBV PreS1-transactivated protein 3 isoform a	218						centrosome|midbody|spindle pole					0		Prostate(90;0.00276)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;4.06e-18)|Epithelial(43;1.18e-15)|OV - Ovarian serous cystadenocarcinoma(60;4.65e-09)|GBM - Glioblastoma multiforme(59;0.00098)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0949)		TGAAGTAAAGGTTCCTGAAAT	0.328													4	27					0	0	0	0	A	175229984	A	A	175229984	3	1	273	1	0	0	0	0	1	0	0	0	8292	1261	44	4	670	4	KIAA1712	4	175229984	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	19701902	175229984	15924292	69	49492											
MARCH11	441061	broad.mit.edu	37	chr5	16177895	16177895	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctataacagcaaagttcacaGgtccaggaacctctctcact	13	9	6	13	0	3	0	2	0	1	0	5	1	4	1	2	2	3	2	2	2	4	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:16177895G>T	uc003jfo.2	-	2	846	c.633C>A	c.(631-633)ACC>ACA	p.T211T	uc003jfp.2_5'Flank	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	211	RING-CH-type.					cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						AAAGTTCACAGGTCCAGGAAC	0.408													7	42					2.0095e-06	2.19412e-06	1	0	T	16177895	T	T	16177895	2	4	273	1	0	0	0	0	0	0	0	1	9353	987	35	4		4	MARCH11	5	16177895	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08		16177895	164737365	70	49493											
CDH18	1016	broad.mit.edu	37	chr5	19747278	19747278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcgtcaatgataaatataGtcccagcaccctctccagta	13	11	5	12	1	2	1	1	1	1	0	5	1	3	1	3	0	1	2	3	0	7	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:19747278G>A	uc003jgc.2	-	3	673	c.296C>T	c.(295-297)ACT>ATT	p.T99I	CDH18_uc003jgd.2_Missense_Mutation_p.T99I|CDH18_uc011cnm.1_Missense_Mutation_p.T99I	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	99	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GATAAATATAGTCCCAGCACC	0.418													41	51					0	0	0	0	A	19747278	A	A	19747278	3	1	273	1	0	0	0	0	1	0	0	0	3118	1029	36	4	2116	4	CDH18	5	19747278	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	3569383	19747278	161167982	71	49494											
PDZD2	23037	broad.mit.edu	37	chr5	32089442	32089443	+	Frame_Shift_Ins	INS	-	TCGT	TCGT																															gtgctggaaagcaagccaccINStcttgccacctctgggccac																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:32089442_32089443insTCGT	uc003jhl.2	+	20	6276_6277	c.5888_5889insTCGT	c.(5887-5889)CCTfs	p.P1963fs	PDZD2_uc003jhm.2_Frame_Shift_Ins_p.P1963fs	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1963					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AGCAAGCCACCTCTTGCCACCT	0.604													---	---	---								TCGT	32089443	TCGT	TCGT	32089442	7	5	273	1	0	1	1	0	0	0	0	0	11755	681	24	0	5962	0	PDZD2	5	32089442	Frame_Shift_Ins	INS	-	TCGA-CX-7086-01A-11D-2078-08	12342164	32089442	148825818	72	49495											
C6	729	broad.mit.edu	37	chr5	41153999	41153999	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcccagcaacaacaaagcCtttggggcaagttagctcaa	13	7	10	11	0	1	0	1	0	0	0	1	0	1	0	2	3	5	4	2	3	6	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:41153999C>T	uc003jmk.2	-	15	2413	c.2203G>A	c.(2203-2205)GGC>AGC	p.G735S	C6_uc003jml.1_Missense_Mutation_p.G735S	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	735	C5b-binding domain.|Sushi 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ACAACAAAGCCTTTGGGGCAA	0.473													12	45					0	0	0	0	T	41153999	T	T	41153999	3	4	273	1	0	0	0	0	1	0	0	0	2325	681	24	4	617	4	C6	5	41153999	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	9064557	41153999	139761261	73	49496											
FGF10	2255	broad.mit.edu	37	chr5	44305279	44305279	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctctccttcagcttacagtCattgttaaattctttctgca	8	17	4	12	0	5	0	2	0	3	0	6	0	5	0	2	0	3	3	2	0	3	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:44305279C>T	uc003jog.1	-	3	445	c.445G>A	c.(445-447)GAC>AAC	p.D149N		NM_004465	NP_004456	O15520	FGF10_HUMAN	fibroblast growth factor 10 precursor	149					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			lung(3)	3	Lung NSC(6;1.12e-06)					AGCTTACAGTCATTGTTAAAT	0.378													12	86					0	0	0	0	T	44305279	T	T	44305279	3	4	273	1	0	0	0	0	1	0	0	0	5871	826	29	2	185	2	FGF10	5	44305279	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	3151280	44305279	136609981	74	49497											
EMB	133418	broad.mit.edu	37	chr5	49706781	49706781	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaataacttcccatttgtttGctattaatgatggtgaacct	11	16	7	7	0	0	2	0	2	0	0	1	3	1	2	2	1	3	2	2	1	5	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:49706781G>A	uc003jom.2	-	4	651	c.402C>T	c.(400-402)AGC>AGT	p.S134S	EMB_uc003jol.2_Silent_p.S65S|EMB_uc011cpy.1_Silent_p.S84S|EMB_uc010ivr.2_Silent_p.S80S	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	134	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				CCATTTGTTTGCTATTAATGA	0.284													5	18					0	0	0	0	A	49706781	A	A	49706781	2	1	273	1	0	0	0	0	0	0	0	1	5109	1310	46	4		4	EMB	5	49706781	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	5401502	49706781	131208479	75	49498											
HTR1A	3350	broad.mit.edu	37	chr5	63256935	63256935	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagcagcagcgggatgtaGaaagctccaaaggtggaata	15	6	14	6	1	0	2	0	1	0	1	1	4	1	4	1	3	4	4	1	3	5	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:63256935G>T	uc011cqt.1	-	1	612	c.612C>A	c.(610-612)TTC>TTA	p.F204L		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	204	Helical; Name=5; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GCGGGATGTAGAAAGCTCCAA	0.582													27	66					7.76418e-22	9.12218e-22	1	0	T	63256935	T	T	63256935	3	4	273	1	0	0	0	0	1	0	0	0	7475	933	33	2	659	2	HTR1A	5	63256935	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	13550154	63256935	117658325	76	49499											
SLCO4C1	353189	broad.mit.edu	37	chr5	101572684	101572684	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttatacaaaaagattgcaaAtccattgaagaacatggtga	18	11	7	5	0	0	4	0	2	0	2	1	4	1	4	1	1	3	1	1	1	7	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:101572684A>G	uc003knm.2	-	13	2340	c.2053T>C	c.(2053-2055)TTT>CTT	p.F685L		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	685	Helical; Name=12; (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		AAGATTGCAAATCCATTGAAG	0.308													13	10					0	0	0	0	G	101572684	G	G	101572684	3	3	273	1	0	0	0	0	1	0	0	0	14794	101	4	5	125	5	SLCO4C1	5	101572684	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	38315749	101572684	79342576	77	49500											
COMMD10	51397	broad.mit.edu	37	chr5	115628170	115628170	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagactatacaagcacagcTggattcccttacatgatgtt	13	11	8	9	0	0	2	0	1	0	1	1	4	1	3	1	1	4	3	1	1	4	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:115628170T>C	uc003krt.1	+	7	616	c.593T>C	c.(592-594)CTG>CCG	p.L198P		NM_016144	NP_057228	Q9Y6G5	COMDA_HUMAN	COMM domain containing 10	198	COMM.						protein binding			ovary(1)	1		all_cancers(142;0.0834)|all_epithelial(76;0.00314)|Prostate(80;0.0102)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;4.3e-07)|Epithelial(69;8.06e-07)|all cancers(49;4.06e-05)		CAAGCACAGCTGGATTCCCTT	0.373													20	33					0	0	0	0	C	115628170	C	C	115628170	3	2	273	1	0	0	0	0	1	0	0	0	3730	1580	55	5	619	5	COMMD10	5	115628170	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	14055486	115628170	65287090	78	49501											
PCDHB12	56124	broad.mit.edu	37	chr5	140590345	140590345	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgtgtgggcgcacaatggCgaggtgcgcaccgccaggct	6	5	18	12	5	0	0	0	0	0	0	0	1	0	0	2	5	1	3	2	5	1	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:140590345C>G	uc003liz.2	+	1	2055	c.1866C>G	c.(1864-1866)GGC>GGG	p.G622G	PCDHB12_uc011dak.1_Silent_p.G285G	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	622	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCACAATGGCGAGGTGCGCA	0.701													12	46					0	0	0	0	G	140590345	G	G	140590345	2	3	273	1	0	0	0	0	0	0	0	1	11591	755	27	3		3	PCDHB12	5	140590345	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	24962175	140590345	40324915	79	49502											
GABRB2	2561	broad.mit.edu	37	chr5	160758096	160758097	+	Missense_Mutation	DNP	GG	TA	TA																															agggagagtttcccggaggtGggtgttgattgtggtcattg																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:160758096_160758097GG>TA	uc003lys.1	-	9	1088_1089	c.870_871CC>TA	c.(868-873)ACCCAC>ACTAAC	p.H291N	GABRB2_uc011deh.1_Missense_Mutation_p.H130N|GABRB2_uc003lyr.1_Missense_Mutation_p.H291N|GABRB2_uc003lyt.1_Missense_Mutation_p.H291N|GABRB2_uc010jiu.1_Missense_Mutation_p.H228N	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	291	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCCCGGAGGTGGGTGTTGATTG	0.426													14	61					0	0	0	0	TA	160758097	TA	TA	160758096	3	4	273	1	0	0	0	0	1	0	0	0	6201	1348	47	4	679	4	GABRB2	5	160758096	Missense_Mutation	DNP	GG	TCGA-CX-7086-01A-11D-2078-08	20167751	160758096	20157164	80	49503											
FAM193B	54540	broad.mit.edu	37	chr5	176951848	176951848	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcctggagcttgtaacgtgTggttctgaggggagcccaaa	8	9	15	9	2	1	1	0	1	1	0	1	3	1	3	2	4	3	3	2	4	2	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr5:176951848T>A	uc003mhs.3	-	8	3124	c.1535A>T	c.(1534-1536)CAC>CTC	p.H512L	FAM193B_uc003mhr.2_Missense_Mutation_p.H49L|FAM193B_uc003mht.2_Missense_Mutation_p.H171L|FAM193B_uc003mhu.2_Missense_Mutation_p.H224L|FAM193B_uc003mhv.2_Missense_Mutation_p.H171L|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	545											0						TTGTAACGTGTGGTTCTGAGG	0.617													7	2					0	0	0	0	A	176951848	A	A	176951848	3	1	273	1	0	0	0	0	1	0	0	0	5553	1696	59	5	846	5	FAM193B	5	176951848	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	16193752	176951848	3963412	81	49504											
SNRNP48	154007	broad.mit.edu	37	chr6	7601613	7601613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aagttcctttgaatcacaaaCggtttgtttgtgatctaact	11	16	7	7	1	2	2	1	2	1	0	3	2	3	2	1	1	2	3	1	1	4	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:7601613C>T	uc003mxr.2	+	5	510	c.451C>T	c.(451-453)CGG>TGG	p.R151W	SNRNP48_uc003mxs.2_RNA	NM_152551	NP_689764	Q6IEG0	SNR48_HUMAN	U11/U12 snRNP 48K	151					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0						GAATCACAAACGGTTTGTTTG	0.328													17	54					0	0	0	0	T	7601613	T	T	7601613	3	4	273	1	0	0	0	0	1	0	0	0	14921	527	19	1	469	1	SNRNP48	6	7601613	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08		7601613	163513454	82	49505											
BAT2	7916	broad.mit.edu	37	chr6	31598493	31598493	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaagttggcctgggtaggaGatgtcttcaccgccacaccc	9	8	11	13	1	2	1	1	0	1	1	2	2	2	1	4	3	0	2	4	3	2	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:31598493G>C	uc003nvb.3	+	15	2629	c.2380G>C	c.(2380-2382)GAT>CAT	p.D794H	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.D794H	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	794	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						CTGGGTAGGAGATGTCTTCAC	0.597													15	30					0	0	0	0	C	31598493	C	C	31598493	3	2	273	1	0	0	0	0	1	0	0	0	1321	942	33	2	2434	2	BAT2	6	31598493	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	23996880	31598493	139516574	83	49506											
DNAH8	1769	broad.mit.edu	37	chr6	38819387	38819387	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttactgtttccaagattcttCtttgtatctgatccagttct	7	20	5	9	0	4	2	0	1	4	1	6	2	6	2	2	0	1	3	2	0	3	7			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:38819387C>T	uc003ooe.1	+	37	5352	c.4752C>T	c.(4750-4752)TTC>TTT	p.F1584F		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CAAGATTCTTCTTTGTATCTG	0.353													6	34					0	0	0	0	T	38819387	T	T	38819387	2	4	273	1	0	0	0	0	0	0	0	1	4629	912	32	2		2	DNAH8	6	38819387	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	7220894	38819387	132295680	84	49507											
TREML1	340205	broad.mit.edu	37	chr6	41119090	41119090	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagaatgcgttctcagccaGactgccaatcttatgggtct	9	12	10	10	1	3	2	1	1	3	2	4	3	3	2	2	1	3	1	2	1	3	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:41119090G>C	uc011duc.1	-	3	453	c.409C>G	c.(409-411)CTG>GTG	p.L137V	TREML1_uc003opx.2_Missense_Mutation_p.L137V|TREML1_uc011dud.1_Missense_Mutation_p.L26V	NM_178174	NP_835468	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid	137	Extracellular (Potential).				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					TTCTCAGCCAGACTGCCAATC	0.517													16	52					0	0	0	0	C	41119090	C	C	41119090	3	2	273	1	0	0	0	0	1	0	0	0	16539	933	33	2	540	2	TREML1	6	41119090	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	2299703	41119090	129995977	85	49508											
PRPH2	5961	broad.mit.edu	37	chr6	42666201	42666202	+	Frame_Shift_Ins	INS	-	T	T																															cctcggggttggacacaccaINStccagcgacgtctgtaggta																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:42666201_42666202insT	uc003osk.2	-	3	1158_1159	c.872_873insA	c.(871-873)GATfs	p.D291fs		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	291	Cytoplasmic (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			TGGACACACCATCCAGCGACGT	0.589													---	---	---								T	42666202	T	T	42666201	7	5	273	1	0	1	1	0	0	0	0	0	12639	214	8	0	171	0	PRPH2	6	42666201	Frame_Shift_Ins	INS	-	TCGA-CX-7086-01A-11D-2078-08	1547111	42666201	128448866	86	49509											
CD109	135228	broad.mit.edu	37	chr6	74477802	74477802	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tatccaggggacagttggtgGctgtaggaaaacaaaattca	14	9	12	6	0	1	0	1	0	0	0	2	2	2	2	1	5	1	3	1	5	6	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:74477802G>T	uc003php.2	+	14	1947	c.1522G>T	c.(1522-1524)GCT>TCT	p.A508S	CD109_uc010kaz.2_Missense_Mutation_p.A508S|CD109_uc003phq.2_Missense_Mutation_p.A508S|CD109_uc010kba.2_Missense_Mutation_p.A431S	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	508						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						ACAGTTGGTGGCTGTAGGAAA	0.363													17	38					2.23348e-06	2.43009e-06	1	0	T	74477802	T	T	74477802	3	4	273	1	0	0	0	0	1	0	0	0	2978	1203	42	4	1576	4	CD109	6	74477802	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	31811601	74477802	96637265	87	49510											
BVES	11149	broad.mit.edu	37	chr6	105573428	105573428	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caaacaatcgccggtacatgCcactgagttccttttcaatc	11	11	6	13	2	1	1	1	1	0	0	4	1	2	1	3	1	3	2	3	1	4	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:105573428C>G	uc003pqw.2	-	4	534	c.377G>C	c.(376-378)GGC>GCC	p.G126A	BVES_uc003pqx.2_Missense_Mutation_p.G126A|BVES_uc003pqy.2_Missense_Mutation_p.G126A	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	126	Cytoplasmic (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				CCGGTACATGCCACTGAGTTC	0.438													13	67					0	0	0	0	G	105573428	G	G	105573428	3	3	273	1	0	0	0	0	1	0	0	0	1580	739	26	4	725	4	BVES	6	105573428	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	31095626	105573428	65541639	88	49511											
RFX6	222546	broad.mit.edu	37	chr6	117248219	117248219	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctttcacagattgctggtCatctgatgacaccacccatt	10	12	7	12	0	3	3	2	2	1	1	3	3	3	3	2	1	2	2	2	1	0	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:117248219C>A	uc003pxm.2	+	17	1978	c.1915C>A	c.(1915-1917)CAT>AAT	p.H639N		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	639					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GATTGCTGGTCATCTGATGAC	0.453													19	55					1.2644e-06	1.39039e-06	1	0	A	117248219	A	A	117248219	3	1	273	1	0	0	0	0	1	0	0	0	13332	826	29	2	1981	2	RFX6	6	117248219	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	11674791	117248219	53866848	89	49512											
C6orf204	387119	broad.mit.edu	37	chr6	118887420	118887420	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cggcatcacatgggcagtagGaagagtaatcaatgattgac	14	8	12	7	1	2	3	2	2	0	1	2	4	2	4	0	3	0	4	0	3	4	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:118887420G>A	uc003pxz.1	-	3	880	c.292C>T	c.(292-294)CCT>TCT	p.P98S	C6orf204_uc003pya.1_Missense_Mutation_p.P101S|C6orf204_uc003pyb.2_Missense_Mutation_p.P98S|C6orf204_uc011ebj.1_5'UTR|C6orf204_uc003pyc.2_Missense_Mutation_p.P101S|C6orf204_uc011ebl.1_5'UTR	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	98						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		TGGGCAGTAGGAAGAGTAATC	0.388													3	26					0	0	0	0	A	118887420	A	A	118887420	3	1	273	1	0	0	0	0	1	0	0	0	2363	1174	41	2	2223	2	C6orf204	6	118887420	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1639201	118887420	52227647	90	49513											
C6orf58	352999	broad.mit.edu	37	chr6	127899855	127899855	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attagctgatccaacccgaaGgacaaactgtggctatgaat	14	9	9	9	1	0	2	0	2	0	0	1	4	1	3	2	2	3	2	2	2	6	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:127899855G>A	uc003qbh.2	+	2	338	c.326G>A	c.(325-327)AGG>AAG	p.R109K		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	109						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		CCAACCCGAAGGACAAACTGT	0.418													53	64					0	0	0	0	A	127899855	A	A	127899855	3	1	273	1	0	0	0	0	1	0	0	0	2377	1000	35	4	332	4	C6orf58	6	127899855	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	9012435	127899855	43215212	91	49514											
LAMA2	3908	broad.mit.edu	37	chr6	129621886	129621886	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttataccggtgaagcttgtGaatgttctcatctgggtaat	9	15	10	7	1	2	2	1	2	2	0	3	2	2	2	1	2	2	3	1	2	5	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:129621886G>A	uc003qbn.2	+	22	3148	c.3043G>A	c.(3043-3045)GAA>AAA	p.E1015K	LAMA2_uc003qbo.2_Missense_Mutation_p.E1015K	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1015	Laminin EGF-like 11.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGAAGCTTGTGAATGTTCTCA	0.378													30	35					0	0	0	0	A	129621886	A	A	129621886	3	1	273	1	0	0	0	0	1	0	0	0	8646	1291	45	2	3129	2	LAMA2	6	129621886	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1722031	129621886	41493181	92	49515											
ARHGAP18	93663	broad.mit.edu	37	chr6	129950552	129950552	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttctccttggagctctcTttctgattgagtgcttgctc	4	19	8	10	0	3	2	0	2	3	0	6	3	3	3	1	1	3	3	1	1	0	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:129950552T>C	uc003qbr.2	-	5	821	c.732A>G	c.(730-732)AAA>AAG	p.K244K	ARHGAP18_uc011ebw.1_Silent_p.K244K	NM_033515	NP_277050	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	244					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			ovary(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		TGGAGCTCTCTTTCTGATTGA	0.418													20	72					0	0	0	0	C	129950552	C	C	129950552	2	2	273	1	0	0	0	0	0	0	0	1	868	1606	56	5		5	ARHGAP18	6	129950552	Silent	SNP	T	TCGA-CX-7086-01A-11D-2078-08	328666	129950552	41164515	93	49516											
ARHGAP18	93663	broad.mit.edu	37	chr6	129959657	129959657	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcttctgaactgctgctGcctgggtccgcgtcaatgtt	4	13	11	13	3	2	1	1	1	1	0	4	1	3	1	2	1	4	4	2	1	2	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:129959657G>T	uc003qbr.2	-	3	523	c.434C>A	c.(433-435)GCA>GAA	p.A145E	ARHGAP18_uc011ebw.1_Missense_Mutation_p.A145E	NM_033515	NP_277050	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	145					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			ovary(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		AACTGCTGCTGCCTGGGTCCG	0.478													25	72					5.35047e-06	5.80104e-06	1	0	T	129959657	T	T	129959657	3	4	273	1	0	0	0	0	1	0	0	0	868	1319	46	4	1609	4	ARHGAP18	6	129959657	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	9105	129959657	41155410	94	49517											
GRM1	2911	broad.mit.edu	37	chr6	146755040	146755040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgtgtcatggtctgaacCaggtggaggacaggtgccca	8	9	15	9	0	3	1	1	1	2	0	3	3	3	3	2	5	2	0	2	5	1	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:146755040C>T	uc010khw.1	+	9	3163	c.2693C>T	c.(2692-2694)CCA>CTA	p.P898L	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_Intron|GRM1_uc011eea.1_Intron	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	898	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TGGTCTGAACCAGGTGGAGGA	0.458													4	32					0	0	0	0	T	146755040	T	T	146755040	3	4	273	1	0	0	0	0	1	0	0	0	6835	594	21	4	2788	4	GRM1	6	146755040	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	16795383	146755040	24360027	95	49518											
TAB2	23118	broad.mit.edu	37	chr6	149700391	149700391	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgagcaataggcaataactCtgcaacctctcctcgagtgg	11	9	9	12	2	2	0	0	0	2	0	5	2	2	0	2	2	4	3	2	2	5	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:149700391C>T	uc003qmj.2	+	3	1518	c.1340C>T	c.(1339-1341)TCT>TTT	p.S447F	TAB2_uc011eec.1_Missense_Mutation_p.S415F|TAB2_uc010kia.1_Missense_Mutation_p.S447F|TAB2_uc010kib.1_Missense_Mutation_p.S447F|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	447					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						GGCAATAACTCTGCAACCTCT	0.502													22	60					0	0	0	0	T	149700391	T	T	149700391	3	4	273	1	0	0	0	0	1	0	0	0	15562	913	32	2	1346	2	TAB2	6	149700391	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	2945351	149700391	21414676	96	49519											
C6orf97	80129	broad.mit.edu	37	chr6	151859372	151859372	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagaacagaaatcacagctCacgctgcaatcaaggagaac	17	5	8	11	1	4	3	4	0	0	3	4	4	4	3	0	1	4	3	0	1	5	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:151859372C>T	uc003qol.2	+	3	468	c.379C>T	c.(379-381)CAC>TAC	p.H127Y		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	127	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		AATCACAGCTCACGCTGCAAT	0.363													10	29					0	0	0	0	T	151859372	T	T	151859372	3	4	273	1	0	0	0	0	1	0	0	0	2385	826	29	2	389	2	C6orf97	6	151859372	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	2158981	151859372	19255695	97	49520											
UNC93A	54346	broad.mit.edu	37	chr6	167728907	167728907	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctccaggacaggtcaaccaGgcagaggatgaagaaataca	16	4	12	9	0	1	3	1	1	0	2	2	5	2	5	2	4	2	2	2	4	4	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr6:167728907G>A	uc003qvq.2	+	8	1516	c.1341G>A	c.(1339-1341)CAG>CAA	p.Q447Q	UNC93A_uc003qvr.2_Silent_p.Q405Q	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	447						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		AGGTCAACCAGGCAGAGGATG	0.532													38	61					0	0	0	0	A	167728907	A	A	167728907	2	1	273	1	0	0	0	0	0	0	0	1	17064	991	35	4		4	UNC93A	6	167728907	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	15869535	167728907	3386160	98	49521											
RADIL	55698	broad.mit.edu	37	chr7	4862158	4862158	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaaccagatcagccatggcGcagctggccagcgagatggg	10	4	16	11	2	1	2	1	0	0	2	1	4	1	3	3	4	4	2	3	4	1	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:4862158G>A	uc003snj.1	-	6	1655	c.1482C>T	c.(1480-1482)TGC>TGT	p.C494C	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_5'UTR|RADIL_uc011jwc.1_Silent_p.C254C|RADIL_uc011jwd.1_Intron	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	494					cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CAGCCATGGCGCAGCTGGCCA	0.532													18	28					0	0	0	0	A	4862158	A	A	4862158	2	1	273	1	0	0	0	0	0	0	0	1	13062	1079	38	1		1	RADIL	7	4862158	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08		4862158	154276505	99	49522											
ANLN	54443	broad.mit.edu	37	chr7	36459826	36459826	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaagacaccagcagaagtGatgaaagtccaaaaccagga	19	4	10	8	0	0	5	0	3	0	2	1	6	1	6	3	1	2	1	3	1	5	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:36459826G>C	uc003tff.2	+	11	2122	c.1918G>C	c.(1918-1920)GAT>CAT	p.D640H	ANLN_uc011kaz.1_Missense_Mutation_p.D552H|ANLN_uc003tfg.2_Missense_Mutation_p.D603H|ANLN_uc010kxe.2_Missense_Mutation_p.D602H	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	640	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						CAGCAGAAGTGATGAAAGTCC	0.403													7	57					0	0	0	0	C	36459826	C	C	36459826	3	2	273	1	0	0	0	0	1	0	0	0	694	1290	45	2	1960	2	ANLN	7	36459826	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	31597668	36459826	122678837	100	49523											
HUS1	3364	broad.mit.edu	37	chr7	48007409	48007409	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaagcacactcactgcataAggcctttgtgggatttactt	11	12	9	9	0	1	1	1	0	0	1	1	2	1	2	1	2	3	2	1	2	3	5	rs79656108		TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:48007409A>C	uc003tod.1	-	7	884	c.754T>G	c.(754-756)TTA>GTA	p.L252V	HUS1_uc003toe.1_Missense_Mutation_p.L252V|HUS1_uc011kce.1_RNA	NM_004507	NP_004498	O60921	HUS1_HUMAN	HUS1 checkpoint protein	252					DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			ovary(2)|lung(2)|kidney(1)	5		Breast(660;0.00139)				TCACTGCATAAGGCCTTTGTG	0.388								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					23	40					0	0	0	0	C	48007409	C	C	48007409	3	2	273	1	0	0	0	0	1	0	0	0	7498	69	3	5	96	5	HUS1	7	48007409	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	11547583	48007409	111131254	101	49524											
ABCA13	154664	broad.mit.edu	37	chr7	48313389	48313389	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaggatgttacgtattctaGacacgttaaattccacattt	13	14	7	7	2	1	2	0	0	1	2	2	3	2	3	1	1	1	3	1	1	5	7			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:48313389G>C	uc003toq.2	+	17	4151	c.4126G>C	c.(4126-4128)GAC>CAC	p.D1376H	ABCA13_uc010kyr.2_Missense_Mutation_p.D879H	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1376					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ACGTATTCTAGACACGTTAAA	0.328													6	15					0	0	0	0	C	48313389	C	C	48313389	3	2	273	1	0	0	0	0	1	0	0	0	31	942	33	2	4021	2	ABCA13	7	48313389	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	305980	48313389	110825274	102	49525											
GRB10	2887	broad.mit.edu	37	chr7	50663143	50663143	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaatacttacaggtaagatCtggaaatttttaattttctg	13	17	6	5	0	3	1	1	0	2	1	3	2	3	2	0	2	2	1	0	2	6	8			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:50663143C>A	uc003tpi.2	-	15	1660	c.1629G>T	c.(1627-1629)CAG>CAT	p.Q543H	GRB10_uc003tph.3_Missense_Mutation_p.Q485H|GRB10_uc003tpj.2_Missense_Mutation_p.Q497H|GRB10_uc003tpk.2_Missense_Mutation_p.Q543H|GRB10_uc010kzb.2_Missense_Mutation_p.Q485H|GRB10_uc003tpl.2_Missense_Mutation_p.Q537H|GRB10_uc003tpm.2_Missense_Mutation_p.Q485H|GRB10_uc003tpn.2_Missense_Mutation_p.Q485H	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	543	SH2.				insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					CAGGTAAGATCTGGAAATTTT	0.398									Russell-Silver_syndrome				56	99					2.31391e-43	2.77131e-43	1	0	A	50663143	A	A	50663143	3	1	273	1	0	0	0	0	1	0	0	0	6795	912	32	2	163	2	GRB10	7	50663143	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	2349754	50663143	108475520	103	49526											
PEX1	5189	broad.mit.edu	37	chr7	92120800	92120800	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagacttaggtcactatcaGagctggaacttccatcctaa	13	10	7	11	0	2	2	2	0	0	2	4	3	4	3	2	2	2	1	2	2	4	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:92120800G>C	uc003uly.2	-	21	3320	c.3224C>G	c.(3223-3225)TCT>TGT	p.S1075C	PEX1_uc011khr.1_Missense_Mutation_p.S867C|PEX1_uc010ley.2_Missense_Mutation_p.S1018C|PEX1_uc011khs.1_Missense_Mutation_p.S753C	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	1075					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GTCACTATCAGAGCTGGAACT	0.373													16	63					0	0	0	0	C	92120800	C	C	92120800	3	2	273	1	0	0	0	0	1	0	0	0	11790	942	33	2	643	2	PEX1	7	92120800	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	41457657	92120800	67017863	104	49527											
CALCR	799	broad.mit.edu	37	chr7	93073008	93073008	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatagatcccttcacagagcAtccagaaatagttgcaggcc	13	8	9	11	0	1	3	1	0	0	3	3	4	3	3	3	1	2	3	3	1	3	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:93073008A>G	uc003umv.1	-	10	1073	c.812T>C	c.(811-813)ATG>ACG	p.M271T	CALCR_uc011kia.1_Missense_Mutation_p.M51T|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.M237T|CALCR_uc003umw.2_Missense_Mutation_p.M237T	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	253	Helical; Name=3; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TTCACAGAGCATCCAGAAATA	0.443													27	71					0	0	0	0	G	93073008	G	G	93073008	3	3	273	1	0	0	0	0	1	0	0	0	2591	217	8	5	738	5	CALCR	7	93073008	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	952208	93073008	66065655	105	49528											
MLL5	55904	broad.mit.edu	37	chr7	104752438	104752438	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaataacaaccaagcactttCaaagaatcatcctcctcaga	18	8	3	12	0	3	2	3	0	0	2	5	2	5	2	3	0	3	1	3	0	6	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:104752438C>G	uc003vcm.2	+	27	4769	c.4235C>G	c.(4234-4236)TCA>TGA	p.S1412*	MLL5_uc010ljc.2_Nonsense_Mutation_p.S1412*|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Nonsense_Mutation_p.S146*	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1412					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						CAAGCACTTTCAAAGAATCAT	0.433													17	81					0	0	0	0	G	104752438	G	G	104752438	4	3	273	1	0	0	0	0	0	1	0	0	9677	838	29	2	4333	2	MLL5	7	104752438	Nonsense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	11679430	104752438	54386225	106	49529											
MDFIC	29969	broad.mit.edu	37	chr7	114619638	114619638	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaataggcaagataaagaacGgccacacaggtctgagcaat	18	5	10	8	1	1	3	0	1	1	2	1	3	1	3	1	3	2	2	1	3	7	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:114619638G>C	uc003vhf.2	+	4	885	c.622G>C	c.(622-624)GGC>CGC	p.G208R		NM_199072	NP_951038	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing protein	99					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleolus|nucleolus|nucleus	cyclin binding|Tat protein binding			ovary(1)	1						GATAAAGAACGGCCACACAGG	0.473													16	20					0	0	0	0	C	114619638	C	C	114619638	3	2	273	1	0	0	0	0	1	0	0	0	9458	1116	39	3	678	3	MDFIC	7	114619638	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	9867200	114619638	44519025	107	49530											
ING3	54556	broad.mit.edu	37	chr7	120590962	120590962	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggccgcgatgttgtacctAgaagactatctggaaagtga	12	9	13	7	2	1	3	0	1	1	2	1	5	1	4	2	2	1	2	2	2	5	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:120590962A>G	uc003vjn.2	+	1	146	c.12A>G	c.(10-12)CTA>CTG	p.L4L	ING3_uc011knr.1_Silent_p.L4L|ING3_uc003vjl.2_Silent_p.L4L|ING3_uc003vjm.1_Silent_p.L4L|ING3_uc003vjo.2_5'UTR|ING3_uc003vjp.2_Silent_p.L4L|ING3_uc011kns.1_5'Flank	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	4					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					TGTTGTACCTAGAAGACTATC	0.443													25	74					0	0	0	0	G	120590962	G	G	120590962	2	3	273	1	0	0	0	0	0	0	0	1	7776	407	15	5		5	ING3	7	120590962	Silent	SNP	A	TCGA-CX-7086-01A-11D-2078-08	5971324	120590962	38547701	108	49531											
MKLN1	4289	broad.mit.edu	37	chr7	131122674	131122674	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaaagtgacttctatcgttAtgacattgatacaaacacat	16	12	6	7	1	1	3	0	3	1	0	2	4	1	3	0	0	2	1	0	0	6	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:131122674A>T	uc011kpm.1	+	10	1155	c.1091A>T	c.(1090-1092)TAT>TTT	p.Y364F	MKLN1_uc011kpl.1_Missense_Mutation_p.Y341F|MKLN1_uc010lmh.2_Missense_Mutation_p.Y364F|MKLN1_uc003vqs.2_Missense_Mutation_p.Y157F	NM_013255	NP_037387	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing	364	Kelch 2.				signal transduction	cytoplasm	protein binding			breast(1)	1	Melanoma(18;0.162)					TTCTATCGTTATGACATTGAT	0.413													56	75					0	0	0	0	T	131122674	T	T	131122674	3	4	273	1	0	0	0	0	1	0	0	0	9656	449	16	5	1162	5	MKLN1	7	131122674	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	10531712	131122674	28015989	109	49532											
PLXNA4	91584	broad.mit.edu	37	chr7	131870132	131870132	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgaaagaccaggtcctggtgGatcttggccctgtccacctg	7	10	12	12	0	1	2	0	1	1	1	3	3	3	3	5	4	0	0	5	4	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:131870132G>C	uc003vra.3	-	16	3313	c.3084C>G	c.(3082-3084)ATC>ATG	p.I1028M		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1028	IPT/TIG 2.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GGTCCTGGTGGATCTTGGCCC	0.557													8	45					0	0	0	0	C	131870132	C	C	131870132	3	2	273	1	0	0	0	0	1	0	0	0	12177	1164	41	2	2668	2	PLXNA4	7	131870132	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	747458	131870132	27268531	110	49533											
GIMAP1	170575	broad.mit.edu	37	chr7	150417901	150417901	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctgtggaagtggctgaagtCccccaggagctggaggctgg	7	7	18	9	0	0	1	0	1	0	0	1	4	1	4	2	6	1	4	2	6	2	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr7:150417901C>T	uc003whq.2	+	3	896	c.809C>T	c.(808-810)TCC>TTC	p.S270F	GIMAP1_uc003whp.2_Missense_Mutation_p.S278F	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	270	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGCTGAAGTCCCCCAGGAGC	0.741													5	4					0	0	0	0	T	150417901	T	T	150417901	3	4	273	1	0	0	0	0	1	0	0	0	6416	855	30	2	815	2	GIMAP1	7	150417901	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	18547769	150417901	8720762	111	49534											
ZNF596	169270	broad.mit.edu	37	chr8	195664	195664	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagacgacatgagatgattCacactagagaaaaagcacag	18	7	9	7	1	1	4	1	2	0	3	1	7	1	4	0	0	1	1	0	0	4	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:195664C>A	uc003wot.2	+	6	1105	c.817C>A	c.(817-819)CAC>AAC	p.H273N	ZNF596_uc003wou.2_Missense_Mutation_p.H172N|ZNF596_uc003wov.2_Missense_Mutation_p.H273N|ZNF596_uc003wow.2_Missense_Mutation_p.H273N	NM_173539	NP_775810	Q8TC21	ZN596_HUMAN	zinc finger protein 596	273	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)		TGAGATGATTCACACTAGAGA	0.408													8	59					0.000274275	0.000287292	1	0	A	195664	A	A	195664	3	1	273	1	0	0	0	0	1	0	0	0	18093	826	29	2	835	2	ZNF596	8	195664	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08		195664	146168358	112	49535											
CSMD1	64478	broad.mit.edu	37	chr8	2886928	2886928	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccttctaagtagtaaccagGactgcagctcagcaatactt	12	10	8	11	0	2	0	1	0	1	0	2	1	2	1	2	1	5	5	2	1	5	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:2886928G>T	uc011kwk.1	-	51	8161	c.7771C>A	c.(7771-7773)CCT>ACT	p.P2591T	CSMD1_uc011kwj.1_Missense_Mutation_p.P1920T|CSMD1_uc010lrg.2_Missense_Mutation_p.P659T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2591	Extracellular (Potential).|Sushi 16.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TAGTAACCAGGACTGCAGCTC	0.532													6	12					0.00198382	0.00206397	1	0	T	2886928	T	T	2886928	3	4	273	1	0	0	0	0	1	0	0	0	3961	1174	41	2	3006	2	CSMD1	8	2886928	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	2691264	2886928	143477094	113	49536											
RP1	6101	broad.mit.edu	37	chr8	55542523	55542523	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttaaagaaatttcaaccagaTttgaaggaaaggttttgtat	16	14	8	3	0	1	3	1	1	0	2	1	4	1	4	1	2	1	2	1	2	7	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:55542523T>A	uc003xsd.1	+	4	6229	c.6081T>A	c.(6079-6081)GAT>GAA	p.D2027E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	2027					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCAACCAGATTTGAAGGAAA	0.338													26	119					0	0	0	0	A	55542523	A	A	55542523	3	1	273	1	0	0	0	0	1	0	0	0	13597	1490	52	5	6091	5	RP1	8	55542523	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	52655595	55542523	90821499	114	49537											
XKR4	114786	broad.mit.edu	37	chr8	56436490	56436490	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacggtccatctccaacaacCgcagtgttgtcagcgaccgc	9	8	9	15	4	2	0	1	0	1	0	4	1	3	0	4	1	4	2	4	1	3	2	rs145363139		TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:56436490C>T	uc003xsf.2	+	3	1689	c.1657C>T	c.(1657-1659)CGC>TGC	p.R553C		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	553						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			CTCCAACAACCGCAGTGTTGT	0.587													30	73					0	0	0	0	T	56436490	T	T	56436490	3	4	273	1	0	0	0	0	1	0	0	0	17501	652	23	1	1667	1	XKR4	8	56436490	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	893967	56436490	89927532	115	49538											
TGS1	96764	broad.mit.edu	37	chr8	56717593	56717593	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttgccttaacaggaatgaGaggtaattagccatcaatgg	13	11	11	6	0	1	1	1	1	0	1	1	3	1	2	2	3	3	2	2	3	5	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:56717593G>C	uc003xsj.3	+	10	2528	c.2141G>C	c.(2140-2142)AGA>ACA	p.R714T	TGS1_uc010lyh.2_Missense_Mutation_p.R618T	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	714	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			ACAGGAATGAGAGGTAATTAG	0.378													15	73					0	0	0	0	C	56717593	C	C	56717593	3	2	273	1	0	0	0	0	1	0	0	0	15903	942	33	2	2179	2	TGS1	8	56717593	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	281103	56717593	89646429	116	49539											
ASPH	444	broad.mit.edu	37	chr8	62555450	62555450	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaaagcatttgcaaaccttGttcctcatagacttggtatg	12	13	8	8	0	1	2	1	0	0	2	2	2	2	2	2	1	3	4	2	1	4	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:62555450G>A	uc003xuj.2	-	10	1056	c.787C>T	c.(787-789)CAA>TAA	p.Q263*	ASPH_uc011leg.1_Nonsense_Mutation_p.Q234*|ASPH_uc003xuo.2_Nonsense_Mutation_p.Q244*|ASPH_uc011leh.1_Nonsense_Mutation_p.Q230*|ASPH_uc003xul.2_Nonsense_Mutation_p.Q249*|ASPH_uc011lei.1_Nonsense_Mutation_p.Q249*|ASPH_uc011lej.1_Nonsense_Mutation_p.Q206*|ASPH_uc003xun.2_Nonsense_Mutation_p.Q220*|ASPH_uc011lek.1_Nonsense_Mutation_p.Q244*|ASPH_uc003xum.2_Nonsense_Mutation_p.Q263*	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	263	Glu-rich.|Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	TGCAAACCTTGTTCCTCATAG	0.164													7	6					0	0	0	0	A	62555450	A	A	62555450	4	1	273	1	0	0	0	0	0	1	0	0	1055	1386	48	4	1565	4	ASPH	8	62555450	Nonsense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	5837857	62555450	83808572	117	49540											
CYP7B1	9420	broad.mit.edu	37	chr8	65528763	65528763	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ataatttattagaaaatactCgaaagcttaattgtttatga	17	16	5	3	1	0	2	0	1	0	1	1	3	0	2	0	0	2	2	0	0	9	9			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:65528763C>T	uc003xvj.2	-	3	539	c.335G>A	c.(334-336)CGA>CAA	p.R112Q		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	112					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				AGAAAATACTCGAAAGCTTAA	0.313													3	36					0	0	0	0	T	65528763	T	T	65528763	3	4	273	1	0	0	0	0	1	0	0	0	4214	884	31	1	1201	1	CYP7B1	8	65528763	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	2973313	65528763	80835259	118	49541											
ENY2	56943	broad.mit.edu	37	chr8	110355642	110355642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttgtttttcagccctggtaCctgacagtgtaaagaaggag	10	13	11	7	0	1	2	1	1	0	1	1	3	1	3	2	2	2	3	2	2	4	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:110355642C>T	uc003ynd.2	+	5	300	c.238C>T	c.(238-240)CCT>TCT	p.P80S	ENY2_uc003ync.2_Missense_Mutation_p.P75S	NM_020189	NP_064574	Q9NPA8	ENY2_HUMAN	enhancer of yellow 2 homolog	80					histone deubiquitination|mRNA transport|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity				0	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;9.05e-13)			AGCCCTGGTACCTGACAGTGT	0.343													49	53					0	0	0	0	T	110355642	T	T	110355642	3	4	273	1	0	0	0	0	1	0	0	0	5170	507	18	4	256	4	ENY2	8	110355642	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	44826879	110355642	36008380	119	49542											
COL14A1	7373	broad.mit.edu	37	chr8	121222116	121222116	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttatgctcctctaacagaGggcctggctggggatgaaaa	10	10	12	9	0	1	2	0	1	1	1	2	3	2	3	2	4	2	2	2	4	4	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:121222116G>A	uc003yox.2	+	12	1708	c.1443G>A	c.(1441-1443)GAG>GAA	p.E481E	COL14A1_uc003yoy.2_Silent_p.E159E|COL14A1_uc010mde.1_Silent_p.E159E	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	481	Fibronectin type-III 3.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CTCTAACAGAGGGCCTGGCTG	0.408													18	49					0	0	0	0	A	121222116	A	A	121222116	2	1	273	1	0	0	0	0	0	0	0	1	3686	991	35	4		4	COL14A1	8	121222116	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	10866474	121222116	25141906	120	49543											
COL14A1	7373	broad.mit.edu	37	chr8	121292244	121292244	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttagcattggcagtaagccCagcgcacgccatgtcttctt	8	11	10	12	2	2	0	0	0	2	0	2	0	2	0	2	1	3	5	2	1	2	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:121292244C>T	uc003yox.2	+	29	3817	c.3552C>T	c.(3550-3552)CCC>CCT	p.P1184P	COL14A1_uc003yoz.2_Silent_p.P149P	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1184	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GCAGTAAGCCCAGCGCACGCC	0.443													5	62					0	0	0	0	T	121292244	T	T	121292244	2	4	273	1	0	0	0	0	0	0	0	1	3686	581	21	4		4	COL14A1	8	121292244	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	70128	121292244	25071778	121	49544											
FBXO32	114907	broad.mit.edu	37	chr8	124526525	124526525	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcatgaagttcttttgggCgatgccactcagggatgtga	9	13	12	7	1	3	2	2	2	1	0	3	4	3	3	1	2	1	1	1	2	1	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:124526525C>T	uc003yqr.2	-	5	613	c.421G>A	c.(421-423)GCC>ACC	p.A141T	FBXO32_uc003yqq.2_5'UTR|FBXO32_uc010mdk.2_Intron	NM_058229	NP_478136	Q969P5	FBX32_HUMAN	F-box only protein 32 isoform 1	141										skin(3)|breast(2)|lung(1)	6	Lung NSC(37;1.13e-13)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TTCTTTTGGGCGATGCCACTC	0.448													4	31					0	0	0	0	T	124526525	T	T	124526525	3	4	273	1	0	0	0	0	1	0	0	0	5774	768	27	1	666	1	FBXO32	8	124526525	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	3234281	124526525	21837497	122	49545											
FAM135B	51059	broad.mit.edu	37	chr8	139263195	139263195	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtggtgcagaccattccggGggtggaagtgcaggccaagc	8	6	18	9	1	0	1	0	0	0	1	1	2	1	2	3	6	3	2	3	6	2	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:139263195G>A	uc003yuy.2	-	6	602	c.431C>T	c.(430-432)CCC>CTC	p.P144L	FAM135B_uc003yux.2_Missense_Mutation_p.P45L|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	144										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACCATTCCGGGGGTGGAAGTG	0.597										HNSCC(54;0.14)			12	134					0	0	0	0	A	139263195	A	A	139263195	3	1	273	1	0	0	0	0	1	0	0	0	5477	1232	43	4	3849	4	FAM135B	8	139263195	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	14736670	139263195	7100827	123	49546											
EPPK1	83481	broad.mit.edu	37	chr8	144946383	144946383	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggagctctgggctgaccaGgcccgccctgactgcctcgt	5	8	13	15	2	1	2	0	2	1	0	2	3	1	3	4	3	2	2	4	3	0	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:144946383G>A	uc003zaa.1	-	1	1052	c.1039C>T	c.(1039-1041)CTG>TTG	p.L347L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	347	Plectin 7.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGCTGACCAGGCCCGCCCTG	0.682													24	15					0	0	0	0	A	144946383	A	A	144946383	2	1	273	1	0	0	0	0	0	0	0	1	5214	991	35	4		4	EPPK1	8	144946383	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	5683188	144946383	1417639	124	49547											
PLEC	5339	broad.mit.edu	37	chr8	144991527	144991527	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccttgcggtaggcctcgtaCactgacatctccttgcccgt	5	11	9	16	3	1	1	0	1	1	0	3	1	1	1	4	2	3	2	4	2	2	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:144991527C>G	uc003zaf.1	-	32	13043	c.12873G>C	c.(12871-12873)GTG>GTC	p.V4291V	PLEC_uc003zab.1_Silent_p.V4154V|PLEC_uc003zac.1_Silent_p.V4158V|PLEC_uc003zad.2_Silent_p.V4154V|PLEC_uc003zae.1_Silent_p.V4122V|PLEC_uc003zag.1_Silent_p.V4132V|PLEC_uc003zah.2_Silent_p.V4140V|PLEC_uc003zaj.2_Silent_p.V4181V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4291	Binding to intermediate filaments (By similarity).|Globular 2.|Plectin 27.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGGCCTCGTACACTGACATCT	0.622													6	72					0	0	0	0	G	144991527	G	G	144991527	2	3	273	1	0	0	0	0	0	0	0	1	12107	465	17	4		4	PLEC	8	144991527	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	45144	144991527	1372495	125	49548											
SPATC1	375686	broad.mit.edu	37	chr8	145096194	145096194	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccttccagctggaccgcagGatcctgtccagcatcttccc	6	9	9	17	1	1	0	0	0	1	0	5	2	5	2	6	2	2	3	6	2	0	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:145096194G>A	uc011lkw.1	+	4	1470	c.1368G>A	c.(1366-1368)AGG>AGA	p.R456R	SPATC1_uc011lkx.1_Intron	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	456										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGACCGCAGGATCCTGTCCA	0.622													7	30					0	0	0	0	A	145096194	A	A	145096194	2	1	273	1	0	0	0	0	0	0	0	1	15083	1165	41	2		2	SPATC1	8	145096194	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	104667	145096194	1267828	126	49549											
NFKBIL2	4796	broad.mit.edu	37	chr8	145662239	145662239	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcgtggaggggggtgatgccTtcgcagccctggccacctgg	4	8	17	12	2	0	1	0	1	0	0	2	2	0	2	4	6	2	1	4	6	0	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:145662239T>C	uc011llg.1	-	15	1806	c.1791A>G	c.(1789-1791)GAA>GAG	p.E597E	uc011llh.1_RNA	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	597	ANK 3.				cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GGGTGATGCCTTCGCAGCCCT	0.657													46	54					0	0	0	0	C	145662239	C	C	145662239	2	2	273	1	0	0	0	0	0	0	0	1	10436	1606	56	5		5	NFKBIL2	8	145662239	Silent	SNP	T	TCGA-CX-7086-01A-11D-2078-08	566045	145662239	701783	127	49550											
ZNF251	90987	broad.mit.edu	37	chr8	145948557	145948557	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggtagcttctgttaaaactCtcttgtgaatattgggtttg	8	17	10	6	1	2	1	0	1	2	0	3	1	2	1	0	2	2	4	0	2	5	7			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr8:145948557C>G	uc003zdv.3	-	5	744	c.488G>C	c.(487-489)AGA>ACA	p.R163T		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TGTTAAAACTCTCTTGTGAAT	0.478													26	87					0	0	0	0	G	145948557	G	G	145948557	3	3	273	1	0	0	0	0	1	0	0	0	17863	913	32	2	1531	2	ZNF251	8	145948557	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	286318	145948557	415465	128	49551											
BNC2	54796	broad.mit.edu	37	chr9	16419593	16419593	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgacgagtccaggcccatGtcatcgagttctttggtcaa	8	11	11	11	3	3	0	2	0	1	0	5	3	4	0	2	2	1	1	2	2	1	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr9:16419593G>A	uc003zml.2	-	7	2834	c.2694C>T	c.(2692-2694)GAC>GAT	p.D898D	BNC2_uc011lmw.1_Silent_p.D803D|BNC2_uc003zmm.2_3'UTR|BNC2_uc011lmv.1_3'UTR|BNC2_uc003zmj.2_3'UTR|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Silent_p.D685D	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	898					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		CCAGGCCCATGTCATCGAGTT	0.542													42	14					0	0	0	0	A	16419593	A	A	16419593	2	1	273	1	0	0	0	0	0	0	0	1	1478	1368	48	4		4	BNC2	9	16419593	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08		16419593	124793838	129	49552											
SLC24A2	25769	broad.mit.edu	37	chr9	19786060	19786060	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaaaaataagctgttaagaGaagcaagctttcccaccaca	17	7	7	10	0	0	1	0	0	0	1	1	2	1	1	2	0	3	5	2	0	6	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr9:19786060G>A	uc003zoa.1	-	1	867	c.805C>T	c.(805-807)CTC>TTC	p.L269F	SLC24A2_uc003zob.1_Missense_Mutation_p.L269F	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	269	Helical; (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GCTGTTAAGAGAAGCAAGCTT	0.393													14	39					0	0	0	0	A	19786060	A	A	19786060	3	1	273	1	0	0	0	0	1	0	0	0	14530	942	33	2	1220	2	SLC24A2	9	19786060	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	3366467	19786060	121427371	130	49553											
IFT74	80173	broad.mit.edu	37	chr9	27056421	27056421	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacatagagtatgaggcactAaaaacacaattgcaagaaaa	22	6	7	6	0	0	3	0	1	0	2	0	3	0	3	0	1	3	3	0	1	10	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr9:27056421A>G	uc010mja.2	+	18	1714	c.1587A>G	c.(1585-1587)CTA>CTG	p.L529L	IFT74_uc010mjb.2_Silent_p.L529L|IFT74_uc003zqg.3_Silent_p.L529L	NM_001099223	NP_001092693	Q96LB3	IFT74_HUMAN	coiled-coil domain containing 2 isoform a	529						cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				skin(1)	1		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		ATGAGGCACTAAAAACACAAT	0.308													21	27					0	0	0	0	G	27056421	G	G	27056421	2	3	273	1	0	0	0	0	0	0	0	1	7602	349	13	5		5	IFT74	9	27056421	Silent	SNP	A	TCGA-CX-7086-01A-11D-2078-08	7270361	27056421	114157010	131	49554											
NUDT2	318	broad.mit.edu	37	chr9	34339067	34339067	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagcatgtggcttgatcatCttccgaagatgcctcattcc	9	12	9	11	1	3	3	2	1	1	2	5	4	5	3	3	1	2	2	3	1	1	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr9:34339067C>G	uc003zub.2	+	4	388	c.30C>G	c.(28-30)ATC>ATG	p.I10M	NUDT2_uc003zuc.2_Missense_Mutation_p.I10M|NUDT2_uc003zud.2_Missense_Mutation_p.I10M	NM_001161	NP_001152	P50583	AP4A_HUMAN	nudix-type motif 2	10	Nudix hydrolase.				induction of apoptosis|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity|bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity|GTP binding				0			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		GCTTGATCATCTTCCGAAGAT	0.428													14	41					0	0	0	0	G	34339067	G	G	34339067	3	3	273	1	0	0	0	0	1	0	0	0	10791	903	32	2	32	2	NUDT2	9	34339067	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	7282646	34339067	106874364	132	49555											
DIRAS2	54769	broad.mit.edu	37	chr9	93375945	93375945	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtcggtgatctgcaatgtGcatatgctcttgtcacagct	7	14	11	9	1	3	1	1	1	2	0	4	1	3	1	0	1	4	4	0	1	2	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr9:93375945G>A	uc004aqx.1	-	2	276	c.165C>T	c.(163-165)TGC>TGT	p.C55C		NM_017594	NP_060064	Q96HU8	DIRA2_HUMAN	Di-Ras2	55					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity				0						TCTGCAATGTGCATATGCTCT	0.567													73	23					0	0	0	0	A	93375945	A	A	93375945	2	1	273	1	0	0	0	0	0	0	0	1	4553	1311	46	4		4	DIRAS2	9	93375945	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	59036878	93375945	47837486	133	49556											
ZNF462	58499	broad.mit.edu	37	chr9	109734354	109734354	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcagtcagctgccctggcaAggaacaacagccgtgttagc	11	7	11	12	1	2	0	2	0	0	0	2	1	2	1	2	2	6	3	2	2	4	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr9:109734354A>T	uc004bcz.2	+	8	6785	c.6496A>T	c.(6496-6498)AGG>TGG	p.R2166W	ZNF462_uc010mto.2_Missense_Mutation_p.R2075W|ZNF462_uc004bda.2_Missense_Mutation_p.R2074W|ZNF462_uc011lvz.1_Missense_Mutation_p.R123W|ZNF462_uc004bdb.1_Missense_Mutation_p.R74W	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2166					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						TGCCCTGGCAAGGAACAACAG	0.527													48	15					0	0	0	0	T	109734354	T	T	109734354	3	4	273	1	0	0	0	0	1	0	0	0	17993	63	3	5	6522	5	ZNF462	9	109734354	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	16358409	109734354	31479077	134	49557											
MUSK	4593	broad.mit.edu	37	chr9	113538912	113538912	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttatcctttccccttcagAttataacaaagaaaacctaa	15	14	2	10	0	1	2	1	0	0	2	3	2	3	2	4	0	2	0	4	0	7	7			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr9:113538912A>C	uc004bey.2	+	10	1459	c.1361A>C	c.(1360-1362)GAT>GCT	p.D454A	MUSK_uc004bez.1_Intron	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	454	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						TCCCCTTCAGATTATAACAAA	0.338													18	56					0	0	0	0	C	113538912	C	C	113538912	3	2	273	1	0	0	0	0	1	0	0	0	10042	347	12	5	1435	5	MUSK	9	113538912	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	3804558	113538912	27674519	135	49558											
TLR4	7099	broad.mit.edu	37	chr9	120475917	120475917	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttgaccttcctggacctctCtcagtgtcaactggagcagt	7	12	9	13	0	3	1	2	1	1	0	5	3	4	3	3	2	2	1	3	2	1	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr9:120475917C>G	uc004bjz.2	+	3	1802	c.1511C>G	c.(1510-1512)TCT>TGT	p.S504C	TLR4_uc004bka.2_Missense_Mutation_p.S464C|TLR4_uc004bkb.2_Missense_Mutation_p.S304C	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	504	LRR 16.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CTGGACCTCTCTCAGTGTCAA	0.438													10	51					0	0	0	0	G	120475917	G	G	120475917	3	3	273	1	0	0	0	0	1	0	0	0	16019	913	32	2	1521	2	TLR4	9	120475917	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	6937005	120475917	20737514	136	49559											
GOLGA2	2801	broad.mit.edu	37	chr9	131022757	131022757	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agcgcaccagctttacaaatCcgctctgcagctcagccagc	10	7	8	16	2	2	0	1	0	1	0	3	0	3	0	3	0	7	5	3	0	2	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr9:131022757C>G	uc011maw.1	-	17	1677	c.1664G>C	c.(1663-1665)GGA>GCA	p.G555A	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004buh.2_Missense_Mutation_p.G28A|uc004bun.2_5'Flank	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	555	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						CTTTACAAATCCGCTCTGCAG	0.612													12	57					0	0	0	0	G	131022757	G	G	131022757	3	3	273	1	0	0	0	0	1	0	0	0	6589	855	30	2	1384	2	GOLGA2	9	131022757	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	10546840	131022757	10190674	137	49560											
PRRX2	51450	broad.mit.edu	37	chr9	132481518	132481518	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caacctccgcaggtgagtgtCccagcccggggcgcggtagc	6	5	15	15	4	0	1	0	1	0	0	2	1	2	1	4	4	3	2	4	4	2	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr9:132481518C>T	uc004byh.2	+	2	495	c.268C>T	c.(268-270)CCC>TCC	p.P90S		NM_016307	NP_057391	Q99811	PRRX2_HUMAN	paired related homeobox 2	90				P -> S (in Ref. 5; AAB39864).		nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		Ovarian(14;0.00556)				AGGTGAGTGTCCCAGCCCGGG	0.657													6	3					0	0	0	0	T	132481518	T	T	132481518	3	4	273	1	0	0	0	0	1	0	0	0	12675	855	30	2	274	2	PRRX2	9	132481518	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1458761	132481518	8731913	138	49561											
PTF1A	256297	broad.mit.edu	37	chr10	23481462	23481462	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccactgcggcggcgagcatGgacgcggtgttgctggagca	6	6	17	12	5	0	0	0	0	0	0	0	3	0	2	1	5	4	4	1	5	0	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr10:23481462G>C	uc001irp.2	+	1	3	c.3G>C	c.(1-3)ATG>ATC	p.M1I		NM_178161	NP_835455	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	1					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				pancreas(1)|skin(1)	2						CGGCGAGCATGGACGCGGTGT	0.657													8	35					0	0	0	0	C	23481462	C	C	23481462	3	2	273	1	0	0	0	0	1	0	0	0	12802	1348	47	4	5	4	PTF1A	10	23481462	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08		23481462	112053285	139	49562											
ZEB1	6935	broad.mit.edu	37	chr10	31803553	31803553	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acatgtgacgcagtctgggtGtaatcgtaaattcaaatgca	13	11	10	7	2	2	1	1	1	1	0	3	1	2	1	0	1	1	4	0	1	4	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr10:31803553G>T	uc001ivs.3	+	6	770	c.707G>T	c.(706-708)TGT>TTT	p.C236F	ZEB1_uc001ivr.3_Missense_Mutation_p.C18F|ZEB1_uc010qee.1_Missense_Mutation_p.C18F|ZEB1_uc010qef.1_Missense_Mutation_p.C18F|ZEB1_uc009xlh.1_RNA|ZEB1_uc009xli.1_RNA|ZEB1_uc009xlj.1_Missense_Mutation_p.C162F|ZEB1_uc010qeg.1_Missense_Mutation_p.C95F|ZEB1_uc009xlk.1_Missense_Mutation_p.C18F|ZEB1_uc001ivt.3_Missense_Mutation_p.C18F|ZEB1_uc001ivu.3_Missense_Mutation_p.C237F|ZEB1_uc001ivv.3_Missense_Mutation_p.C216F|ZEB1_uc010qeh.1_Missense_Mutation_p.C169F|ZEB1_uc009xll.2_RNA|ZEB1_uc009xlm.1_RNA|ZEB1_uc009xln.1_RNA|ZEB1_uc009xlo.1_Missense_Mutation_p.C219F|ZEB1_uc009xlp.2_Missense_Mutation_p.C220F	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	236					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				CAGTCTGGGTGTAATCGTAAA	0.328													7	41					2.0095e-06	2.19412e-06	1	0	T	31803553	T	T	31803553	3	4	273	1	0	0	0	0	1	0	0	0	17690	1377	48	4	743	4	ZEB1	10	31803553	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	8322091	31803553	103731194	140	49563											
KIAA0913	23053	broad.mit.edu	37	chr10	75552009	75552009	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgcctctcagctgaaggggGagataaagctctacataaga	13	7	11	10	1	2	3	1	1	2	2	3	4	2	3	2	2	3	2	2	2	5	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr10:75552009G>A	uc009xrl.2	+	10	1744	c.1712G>A	c.(1711-1713)GGA>GAA	p.G571E	KIAA0913_uc001jve.2_Missense_Mutation_p.G571E|KIAA0913_uc001jvf.2_Missense_Mutation_p.G571E|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_5'UTR|KIAA0913_uc010qkr.1_5'UTR|KIAA0913_uc001jvj.2_5'UTR	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	571	Gly-rich.						zinc ion binding			breast(1)	1	Prostate(51;0.0112)					GCTGAAGGGGGAGATAAAGCT	0.652													3	35					0	0	0	0	A	75552009	A	A	75552009	3	1	273	1	0	0	0	0	1	0	0	0	8239	1174	41	2	1750	2	KIAA0913	10	75552009	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	43748456	75552009	59982738	141	49564											
IFIT2	3433	broad.mit.edu	37	chr10	91066959	91066959	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaagatgaaagacaaactgCaaaaaattgccaaaatgcga	23	5	7	6	1	0	3	0	1	0	2	0	4	0	3	1	0	4	1	1	0	9	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr10:91066959C>A	uc009xts.2	+	2	1421	c.1246C>A	c.(1246-1248)CAA>AAA	p.Q416K	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	416					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				AGACAAACTGCAAAAAATTGC	0.388													23	76					9.57634e-11	1.09191e-10	1	0	A	91066959	A	A	91066959	3	1	273	1	0	0	0	0	1	0	0	0	7562	711	25	4	1252	4	IFIT2	10	91066959	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	15514950	91066959	44467788	142	49565											
CYP26A1	1592	broad.mit.edu	37	chr10	94835689	94835689	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctctacccacatgttctccAgaaagtgcgagaagagctga	12	8	10	11	1	2	4	0	1	2	3	3	5	2	4	2	0	3	3	2	0	3	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr10:94835689A>G	uc001kil.2	+	5	1016	c.971A>G	c.(970-972)CAG>CGG	p.Q324R	CYP26A1_uc001kik.1_Missense_Mutation_p.Q255R|CYP26A1_uc001kim.1_Missense_Mutation_p.Q222R	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	324					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)				CATGTTCTCCAGAAAGTGCGA	0.512													21	18					0	0	0	0	G	94835689	G	G	94835689	3	3	273	1	0	0	0	0	1	0	0	0	4172	188	7	5	989	5	CYP26A1	10	94835689	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	3768730	94835689	40699058	143	49566											
ACSL5	51703	broad.mit.edu	37	chr10	114177625	114177625	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcctgggcggaagggttCgtgtaattgtcactggagct	8	10	15	8	2	1	0	1	0	0	0	2	2	1	2	1	4	2	3	1	4	2	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr10:114177625C>A	uc001kzs.2	+	14	1381	c.1240C>A	c.(1240-1242)CGT>AGT	p.R414S	ACSL5_uc001kzt.2_Missense_Mutation_p.R414S|ACSL5_uc001kzu.2_Missense_Mutation_p.R470S|ACSL5_uc009xxz.2_Missense_Mutation_p.R414S|ACSL5_uc010qrj.1_Missense_Mutation_p.R196S	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	414	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		CGGAAGGGTTCGTGTAATTGT	0.383													31	25					3.86903e-22	4.56309e-22	1	0	A	114177625	A	A	114177625	3	1	273	1	0	0	0	0	1	0	0	0	180	884	31	3	1462	3	ACSL5	10	114177625	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	19341936	114177625	21357122	144	49567											
DMBT1	1755	broad.mit.edu	37	chr10	124336113	124336113	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctggtttggccagggctCaggacccattgccctggatg	5	10	14	12	0	1	0	1	0	0	0	1	2	1	2	4	5	2	2	4	5	0	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr10:124336113C>A	uc001lgk.1	+	7	588	c.482C>A	c.(481-483)TCA>TAA	p.S161*	DMBT1_uc001lgl.1_Nonsense_Mutation_p.S161*|DMBT1_uc001lgm.1_Nonsense_Mutation_p.S161*|DMBT1_uc009xzz.1_Nonsense_Mutation_p.S161*|DMBT1_uc010qtx.1_Nonsense_Mutation_p.S161*|DMBT1_uc009yaa.1_Nonsense_Mutation_p.S13*	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	161	SRCR 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGCCAGGGCTCAGGACCCATT	0.592													35	92					1.99505e-19	2.33512e-19	1	0	A	124336113	A	A	124336113	4	1	273	1	0	0	0	0	0	1	0	0	4599	838	29	2	508	2	DMBT1	10	124336113	Nonsense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	10158488	124336113	11198634	145	49568											
PHRF1	57661	broad.mit.edu	37	chr11	607244	607244	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcacccccgcccgcaccgcGggggcgcctgtgaggctgga	4	3	16	18	6	0	1	0	1	0	0	0	2	0	2	5	4	0	3	5	4	0	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:607244G>A	uc001lqe.2	+	14	1919	c.1788G>A	c.(1786-1788)GCG>GCA	p.A596A	PHRF1_uc010qwc.1_Silent_p.A595A|PHRF1_uc010qwd.1_Silent_p.A594A|PHRF1_uc010qwe.1_Silent_p.A592A|PHRF1_uc009ybz.1_Silent_p.A386A|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	596							RNA polymerase binding|zinc ion binding				0						CCCGCACCGCGGGGGCGCCTG	0.692													14	44					0	0	0	0	A	607244	A	A	607244	2	1	273	1	0	0	0	0	0	0	0	1	11916	1103	39	1		1	PHRF1	11	607244	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08		607244	134399272	146	49569											
OR51M1	390059	broad.mit.edu	37	chr11	5410918	5410918	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccaccactatggggatctTctggtttaactcccatagta	9	12	8	12	0	2	0	0	0	2	0	3	1	3	1	3	3	1	2	3	3	4	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:5410918T>C	uc010qzc.1	+	1	290	c.290T>C	c.(289-291)TTC>TCC	p.F97S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	97						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGGGGATCTTCTGGTTTAAC	0.502													33	82					0	0	0	0	C	5410918	C	C	5410918	3	2	273	1	0	0	0	0	1	0	0	0	11157	1783	62	5	292	5	OR51M1	11	5410918	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	4803674	5410918	129595598	147	49570											
CCKBR	887	broad.mit.edu	37	chr11	6292427	6292427	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctaagaagcgcgtggtgcGaatgttgctggtgatcgttg	7	11	17	6	4	0	2	0	1	0	1	1	3	0	2	0	3	3	4	0	3	3	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:6292427G>A	uc001mcp.2	+	5	1191	c.998G>A	c.(997-999)CGA>CAA	p.R333Q	CCKBR_uc001mcq.2_Missense_Mutation_p.R261Q|CCKBR_uc001mcr.2_Missense_Mutation_p.R333Q|CCKBR_uc001mcs.2_Missense_Mutation_p.R402Q|CCKBR_uc001mct.1_RNA	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	333	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	CGCGTGGTGCGAATGTTGCTG	0.632													6	37					0	0	0	0	A	6292427	A	A	6292427	3	1	273	1	0	0	0	0	1	0	0	0	2894	1058	37	1	1016	1	CCKBR	11	6292427	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	881509	6292427	128714089	148	49571											
PIK3C2A	5286	broad.mit.edu	37	chr11	17122958	17122958	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgacatatgccatatcagagGtcagcacaaaaggagcccga	15	6	10	10	1	2	2	2	1	0	1	2	4	2	3	2	2	3	1	2	2	4	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:17122958G>A	uc001mmq.3	-	24	3941	c.3875C>T	c.(3874-3876)ACC>ATC	p.T1292I	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.T912I|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1292	PI3K/PI4K.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	CATATCAGAGGTCAGCACAAA	0.373													7	32					0	0	0	0	A	17122958	A	A	17122958	3	1	273	1	0	0	0	0	1	0	0	0	11964	1261	44	4	1221	4	PIK3C2A	11	17122958	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	10830531	17122958	117883558	149	49572											
NELL1	4745	broad.mit.edu	37	chr11	20907084	20907084	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaaaagcatggcttattcAaagtaagcactaacgttctt	15	11	6	9	1	2	0	1	0	1	0	2	0	2	0	1	1	3	5	1	1	6	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:20907084A>G	uc001mqe.2	+	5	754	c.601A>G	c.(601-603)AAA>GAA	p.K201E	NELL1_uc001mqf.2_Missense_Mutation_p.K201E|NELL1_uc009yid.2_Missense_Mutation_p.K229E|NELL1_uc010rdo.1_Missense_Mutation_p.K144E|NELL1_uc010rdp.1_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	201	TSP N-terminal.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TGGCTTATTCAAAGTAAGCAC	0.393													13	26					0	0	0	0	G	20907084	G	G	20907084	3	3	273	1	0	0	0	0	1	0	0	0	10387	131	5	5	619	5	NELL1	11	20907084	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	3784126	20907084	114099432	150	49573											
OR4C46	119749	broad.mit.edu	37	chr11	51515583	51515583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgcatgactcaagtctttgGagaacatttcttcggaggtg	10	13	11	7	1	3	2	1	1	2	1	4	4	3	3	0	3	2	1	0	3	2	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:51515583G>A	uc010ric.1	+	1	302	c.302G>A	c.(301-303)GGA>GAA	p.G101E		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	101	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CAAGTCTTTGGAGAACATTTC	0.463													21	69					0	0	0	0	A	51515583	A	A	51515583	3	1	273	1	0	0	0	0	1	0	0	0	11105	1174	41	2	304	2	OR4C46	11	51515583	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	30608499	51515583	83490933	151	49574											
OR5F1	338674	broad.mit.edu	37	chr11	55761812	55761812	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaagtacatctgtaggaagCagccagcaaaagagatggtt	16	7	12	6	0	1	2	0	0	1	2	1	4	1	3	1	2	4	5	1	2	6	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:55761812C>A	uc010riv.1	-	1	290	c.290G>T	c.(289-291)TGC>TTC	p.C97F		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CTGTAGGAAGCAGCCAGCAAA	0.473													23	67					1.42536e-11	1.64341e-11	1	0	A	55761812	A	A	55761812	3	1	273	1	0	0	0	0	1	0	0	0	11212	710	25	4	657	4	OR5F1	11	55761812	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	4246229	55761812	79244704	152	49575											
DAK	26007	broad.mit.edu	37	chr11	61110820	61110820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggtattgcagagggccGcggggtgaagattgcccgtg	6	9	17	9	3	1	3	0	1	1	2	1	3	1	3	2	4	2	2	2	4	2	3	rs142716350	byFrequency	TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:61110820G>A	uc001nre.2	+	11	1129	c.872G>A	c.(871-873)CGC>CAC	p.R291H	DDB1_uc010rlf.1_5'Flank|DAK_uc009ynm.1_Missense_Mutation_p.R221H	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	291	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						GCAGAGGGCCGCGGGGTGAAG	0.562													22	61					0	0	0	0	A	61110820	A	A	61110820	3	1	273	1	0	0	0	0	1	0	0	0	4245	1087	38	1	910	1	DAK	11	61110820	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	5349008	61110820	73895696	153	49576											
LTBP3	4054	broad.mit.edu	37	chr11	65308358	65308358	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaccacggtgggctgggatGccgtagttgacgatgttgtt	6	13	15	7	3	0	1	0	1	0	0	0	3	0	2	2	3	2	5	2	3	2	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:65308358G>A	uc001oej.2	-	21	3230	c.2961C>T	c.(2959-2961)GGC>GGT	p.G987G	LTBP3_uc001oef.2_5'UTR|LTBP3_uc001oeg.2_5'UTR|LTBP3_uc001oeh.2_Silent_p.G417G|LTBP3_uc010roi.1_Silent_p.G870G|LTBP3_uc001oei.2_Silent_p.G987G|LTBP3_uc010roj.1_Silent_p.G688G|LTBP3_uc010rok.1_Silent_p.G898G	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	987						extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						GGGCTGGGATGCCGTAGTTGA	0.706											OREG0021080	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	6					0	0	0	0	A	65308358	A	A	65308358	2	1	273	1	0	0	0	0	0	0	0	1	9125	1306	46	4		4	LTBP3	11	65308358	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	4197538	65308358	69698158	154	49577											
EHBP1L1	254102	broad.mit.edu	37	chr11	65350494	65350494	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagatagcatctagggattCaggggtcccagggttagaag	12	8	15	6	0	2	2	1	0	1	2	3	4	3	3	1	4	1	2	1	4	4	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:65350494C>T	uc001oeo.3	+	9	2616	c.2351C>T	c.(2350-2352)TCA>TTA	p.S784L	EHBP1L1_uc001oep.1_Intron	NM_001099409	NP_001092879	Q8N3D4	EH1L1_HUMAN	tangerin	784	Glu-rich.									central_nervous_system(1)	1						TCTAGGGATTCAGGGGTCCCA	0.542													8	27					0	0	0	0	T	65350494	T	T	65350494	3	4	273	1	0	0	0	0	1	0	0	0	4998	838	29	2	2385	2	EHBP1L1	11	65350494	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	42136	65350494	69656022	155	49578											
SPTBN2	6712	broad.mit.edu	37	chr11	66460538	66460557	+	Frame_Shift_Del	DEL	GCTTCTTCACCTCTGCCTGG	-	-																															ggcttgctccagcacctggtGcttcttcacctctgcctggg																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:66460538_66460557delGCTTCTTCACCTCTGCCTGG	uc001ojd.2	-	24	4941_4960	c.4869_4888delCCAGGCAGAGGTGAAGAAGC	c.(4867-4890)GCCCAGGCAGAGGTGAAGAAGCACfs	p.A1623fs		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1623_1630	Spectrin 13.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						AGCACCTGGTGCTTCTTCACCTCTGCCTGGGCACTCAGCT	0.632													---	---	---								-	66460557	-	-	66460538	7	5	273	1	0	1	0	1	0	0	0	0	15186	1319	46	0	2340	0	SPTBN2	11	66460538	Frame_Shift_Del	DEL	GCTTCTTCACCTCTGCCTGG	TCGA-CX-7086-01A-11D-2078-08	1110044	66460538	68545978	156	49579											
KDM2A	22992	broad.mit.edu	37	chr11	66888812	66888812	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacccgaagaagaaaggattCgttacagccagagattggtt	15	8	11	7	2	0	3	0	0	0	3	1	6	0	4	2	2	3	2	2	2	5	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:66888812C>T	uc001ojw.2	+	2	889	c.25C>T	c.(25-27)CGT>TGT	p.R9C	KDM2A_uc001ojx.2_RNA	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						AGAAAGGATTCGTTACAGCCA	0.423													8	23					0	0	0	0	T	66888812	T	T	66888812	3	4	273	1	0	0	0	0	1	0	0	0	8163	884	31	1	27	1	KDM2A	11	66888812	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	428274	66888812	68117704	157	49580											
ALDH3B1	221	broad.mit.edu	37	chr11	67789312	67789312	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgtgtggccattgggggcCagagcgatgagagcgatcgc	7	6	19	9	4	0	2	0	1	0	2	1	5	0	2	2	4	2	0	2	4	0	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:67789312C>T	uc010rpy.1	+	9	1038	c.922C>T	c.(922-924)CAG>TAG	p.Q308*	ALDH3B1_uc001omz.2_Nonsense_Mutation_p.Q308*|ALDH3B1_uc001ona.2_Nonsense_Mutation_p.Q271*|ALDH3B1_uc001onb.2_RNA	NM_001161473	NP_001154945	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3B1 isoform a	308					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase				0					NADH(DB00157)	CATTGGGGGCCAGAGCGATGA	0.662													13	37					0	0	0	0	T	67789312	T	T	67789312	4	4	273	1	0	0	0	0	0	1	0	0	499	581	21	4	942	4	ALDH3B1	11	67789312	Nonsense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	900500	67789312	67217204	158	49581											
PPFIA1	8500	broad.mit.edu	37	chr11	70171106	70171106	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatttgaacaccacaaagctCtggatgaaaaggtgccatca	15	9	8	9	0	2	2	1	2	1	0	2	3	2	3	2	2	3	1	2	2	5	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:70171106C>G	uc001opo.2	+	4	718	c.520C>G	c.(520-522)CTG>GTG	p.L174V	PPFIA1_uc001opn.1_Missense_Mutation_p.L174V|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_5'Flank	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	174					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CCACAAAGCTCTGGATGAAAA	0.473													16	341					0	0	0	0	G	70171106	G	G	70171106	3	3	273	1	0	0	0	0	1	0	0	0	12364	912	32	2	530	2	PPFIA1	11	70171106	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	2381794	70171106	64835410	159	49582											
PPFIA1	8500	broad.mit.edu	37	chr11	70176374	70176374	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccacatctgtgcatgacctCaatgataaacttgaaaatga	15	10	7	9	0	2	4	1	4	1	0	2	4	2	4	2	0	2	1	2	0	5	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:70176374C>G	uc001opo.2	+	8	1224	c.1026C>G	c.(1024-1026)CTC>CTG	p.L342L	PPFIA1_uc001opn.1_Silent_p.L342L|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	342	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGCATGACCTCAATGATAAAC	0.383													12	296					0	0	0	0	G	70176374	G	G	70176374	2	3	273	1	0	0	0	0	0	0	0	1	12364	813	29	2		2	PPFIA1	11	70176374	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	5268	70176374	64830142	160	49583											
KIAA1377	57562	broad.mit.edu	37	chr11	101832997	101832997	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagagaccattagttactGagagcccaacatttaaattt	15	11	8	7	0	0	3	0	1	0	3	0	6	0	3	2	0	3	1	2	0	5	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr11:101832997G>A	uc001pgm.2	+	6	1501	c.1231G>A	c.(1231-1233)GAG>AAG	p.E411K	KIAA1377_uc001pgn.2_Missense_Mutation_p.E367K|KIAA1377_uc010run.1_Missense_Mutation_p.E212K|KIAA1377_uc009yxa.1_Missense_Mutation_p.E212K	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	411							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		ATTAGTTACTGAGAGCCCAAC	0.378													8	174					0	0	0	0	A	101832997	A	A	101832997	3	1	273	1	0	0	0	0	1	0	0	0	8266	1291	45	2	1253	2	KIAA1377	11	101832997	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	31656623	101832997	33173519	161	49584											
ADIPOR2	79602	broad.mit.edu	37	chr12	1889776	1889776	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacacagtctactgccactCagagggggtctctcggctct	7	9	10	15	1	4	1	1	0	3	1	6	1	4	1	2	3	2	1	2	3	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:1889776C>T	uc001qjm.2	+	5	820	c.623C>T	c.(622-624)TCA>TTA	p.S208L	ADIPOR2_uc001qjn.2_Missense_Mutation_p.S208L	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	208	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)			TACTGCCACTCAGAGGGGGTC	0.458													28	176					0	0	0	0	T	1889776	T	T	1889776	3	4	273	1	0	0	0	0	1	0	0	0	319	838	29	2	637	2	ADIPOR2	12	1889776	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08		1889776	131962119	162	49585											
VWF	7450	broad.mit.edu	37	chr12	6128892	6128892	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcaggcttcacaggtgaggTtgacaacatcacagtggctg	10	8	14	9	0	2	2	2	2	0	0	2	2	2	2	0	5	1	4	0	5	1	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:6128892T>G	uc001qnn.1	-	28	3942	c.3692A>C	c.(3691-3693)AAC>ACC	p.N1231T	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1231					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	ACAGGTGAGGTTGACAACATC	0.542													4	19					0	0	0	0	G	6128892	G	G	6128892	3	3	273	1	0	0	0	0	1	0	0	0	17314	1725	60	5	4849	5	VWF	12	6128892	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	4239116	6128892	127723003	163	49586											
CD163	9332	broad.mit.edu	37	chr12	7649555	7649555	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atcccttactggcgttaactCgaccaatggctgtgacggca	9	10	10	12	3	0	1	0	1	0	0	2	2	1	1	2	3	2	3	2	3	3	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:7649555C>G	uc001qsz.3	-	5	1081	c.953G>C	c.(952-954)CGA>CCA	p.R318P	CD163_uc001qta.3_Missense_Mutation_p.R318P|CD163_uc009zfw.2_Missense_Mutation_p.R318P	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	318	SRCR 3.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GGCGTTAACTCGACCAATGGC	0.517													35	34					0	0	0	0	G	7649555	G	G	7649555	3	3	273	1	0	0	0	0	1	0	0	0	2982	884	31	3	2565	3	CD163	12	7649555	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1520663	7649555	126202340	164	49587											
C3AR1	719	broad.mit.edu	37	chr12	8211882	8211882	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcgtagaaggaattgctagaAgcgctagggaacagctttaa	14	9	12	6	2	0	2	0	0	0	2	1	4	0	4	0	2	4	4	0	2	8	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:8211882A>T	uc001qtv.1	-	2	992	c.900T>A	c.(898-900)GCT>GCA	p.A300A		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	300	Extracellular (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		AATTGCTAGAAGCGCTAGGGA	0.448													34	64					0	0	0	0	T	8211882	T	T	8211882	2	4	273	1	0	0	0	0	0	0	0	1	2215	59	3	5		5	C3AR1	12	8211882	Silent	SNP	A	TCGA-CX-7086-01A-11D-2078-08	562327	8211882	125640013	165	49588											
ABCC9	10060	broad.mit.edu	37	chr12	21998701	21998702	+	Missense_Mutation	DNP	GC	TT	TT																															gcgccagcaggttttccatgGcattttagtcctgagcctca																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:21998701_21998702GC>TT	uc001rfi.1	-	24	2951_2952	c.2931_2932GC>AA	c.(2929-2934)ATGCCA>ATAACA	p.977_978MP>IT	ABCC9_uc001rfh.2_Missense_Mutation_p.977_978MP>IT|ABCC9_uc001rfj.1_Missense_Mutation_p.941_942MP>IT	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	977_978	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTTTTCCATGGCATTTTAGTCC	0.421													9	46					0	0	0	0	TT	21998702	TT	TT	21998701	3	4	273	1	0	0	0	0	1	0	0	0	59	1203	42	4	1919	4	ABCC9	12	21998701	Missense_Mutation	DNP	GC	TCGA-CX-7086-01A-11D-2078-08	13786819	21998701	111853194	166	49589											
TMTC1	83857	broad.mit.edu	37	chr12	29689237	29689237	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaggtgatagcttcttcctTtttctcctgggacctataga	8	16	8	9	0	2	2	0	1	2	1	4	3	3	3	3	2	1	1	3	2	4	8			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:29689237T>G	uc001rjb.2	-	11	1840	c.1366A>C	c.(1366-1368)AAG>CAG	p.K456Q	TMTC1_uc001riz.2_Missense_Mutation_p.K213Q|TMTC1_uc001rja.2_Missense_Mutation_p.K300Q|TMTC1_uc001rjc.1_Missense_Mutation_p.K518Q	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	564	TPR 3.					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GCTTCTTCCTTTTTCTCCTGG	0.378													38	52					0	0	0	0	G	29689237	G	G	29689237	3	3	273	1	0	0	0	0	1	0	0	0	16326	1850	64	5	990	5	TMTC1	12	29689237	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	7690536	29689237	104162658	167	49590											
RAPGEF3	10411	broad.mit.edu	37	chr12	48143226	48143226	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgcaggaaatgacagttgtCttctcgcaggatgatggtgg	10	10	14	7	2	2	2	0	2	2	0	3	4	2	4	0	4	0	3	0	4	1	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:48143226C>T	uc009zkp.2	-	9	1302	c.862G>A	c.(862-864)GAC>AAC	p.D288N	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Missense_Mutation_p.D288N|RAPGEF3_uc001rpz.3_Missense_Mutation_p.D330N|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Missense_Mutation_p.D342N|RAPGEF3_uc001rqb.3_Missense_Mutation_p.D330N	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	288					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		TGACAGTTGTCTTCTCGCAGG	0.582													6	50					0	0	0	0	T	48143226	T	T	48143226	3	4	273	1	0	0	0	0	1	0	0	0	13110	913	32	2	1859	2	RAPGEF3	12	48143226	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	18453989	48143226	85708669	168	49591											
MLL2	8085	broad.mit.edu	37	chr12	49445184	49445184	+	Frame_Shift_Del	DEL	A	-	-																															gctcctcagcctgcggagatAggtgtggctcctcaggccgg																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:49445184delA	uc001rta.3	-	10	2282	c.2282delT	c.(2281-2283)CTAfs	p.L761fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	761	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTGCGGAGATAGGTGTGGCTC	0.697			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								-	49445184	-	-	49445184	7	5	273	1	0	1	0	1	0	0	0	0	9674	420	15	0	14511	0	MLL2	12	49445184	Frame_Shift_Del	DEL	A	TCGA-CX-7086-01A-11D-2078-08	1301958	49445184	84406711	169	49592											
GLI1	2735	broad.mit.edu	37	chr12	57858517	57858517	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagaagcgggcactgtccatCtcacctctgtcggatgccag	9	8	11	13	2	2	1	1	0	2	1	5	2	3	2	3	2	2	1	3	2	2	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:57858517C>G	uc001snx.2	+	4	333	c.255C>G	c.(253-255)ATC>ATG	p.I85M	GLI1_uc009zpp.2_RNA|GLI1_uc009zpq.2_Translation_Start_Site|GLI1_uc009zpr.1_RNA	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	85					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CACTGTCCATCTCACCTCTGT	0.587													12	33					0	0	0	0	G	57858517	G	G	57858517	3	3	273	1	0	0	0	0	1	0	0	0	6474	903	32	2	265	2	GLI1	12	57858517	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	8413333	57858517	75993378	170	49593											
LRRIQ1	84125	broad.mit.edu	37	chr12	85500352	85500352	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctattctctccatgaattGtctcttactggaaacccact	9	15	5	12	0	2	1	0	1	2	0	5	2	3	2	2	1	3	1	2	1	4	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:85500352G>T	uc001tac.2	+	15	3447	c.3336G>T	c.(3334-3336)TTG>TTT	p.L1112F	LRRIQ1_uc001tab.1_Missense_Mutation_p.L1112F	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1112										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TCCATGAATTGTCTCTTACTG	0.338													8	49					0.000157383	0.000165413	1	0	T	85500352	T	T	85500352	3	4	273	1	0	0	0	0	1	0	0	0	9079	1368	48	4	3390	4	LRRIQ1	12	85500352	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	27641835	85500352	48351543	171	49594											
UTP20	27340	broad.mit.edu	37	chr12	101685601	101685601	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agattaaaaggttgttggaaAcataccttatacttgtaaaa	17	13	7	4	0	0	1	0	0	0	1	0	2	0	2	1	2	3	3	1	2	8	8			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:101685601A>G	uc001tia.1	+	9	1129	c.973A>G	c.(973-975)ACA>GCA	p.T325A		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	325					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						GTTGTTGGAAACATACCTTAT	0.383													7	20					0	0	0	0	G	101685601	G	G	101685601	3	3	273	1	0	0	0	0	1	0	0	0	17167	43	2	5	1007	5	UTP20	12	101685601	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	16185249	101685601	32166294	172	49595											
NUAK1	9891	broad.mit.edu	37	chr12	106461427	106461427	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggcactgcatcctgaccaGactgagcaaagtcattctct	11	9	8	13	0	2	3	1	2	1	1	4	3	3	3	2	1	2	3	2	1	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr12:106461427G>A	uc001tlj.1	-	7	2519	c.1139C>T	c.(1138-1140)TCT>TTT	p.S380F		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	380							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						ATCCTGACCAGACTGAGCAAA	0.542													26	65					0	0	0	0	A	106461427	A	A	106461427	3	1	273	1	0	0	0	0	1	0	0	0	10766	942	33	2	850	2	NUAK1	12	106461427	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	4775826	106461427	27390468	173	49596											
SACS	26278	broad.mit.edu	37	chr13	23945292	23945292	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcagatctccaatcttgaTccagtcagataactgaaaaa	16	10	6	9	0	4	4	2	2	2	2	6	4	5	4	2	0	1	0	2	0	4	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr13:23945292T>A	uc001uon.2	-	4	773	c.184A>T	c.(184-186)ATC>TTC	p.I62F	SACS_uc001uoo.2_Intron|SACS_uc001uoq.1_5'Flank	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	62	Ubiquitin-like.				cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CCAATCTTGATCCAGTCAGAT	0.303													9	21					0	0	0	0	A	23945292	A	A	23945292	3	1	273	1	0	0	0	0	1	0	0	0	13869	1435	50	5	13583	5	SACS	13	23945292	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08		23945292	91224586	174	49597											
NBEA	26960	broad.mit.edu	37	chr13	35517144	35517144	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccccgcggggatgattaacCcttcggtgccgatccgcaac	7	8	11	15	5	0	1	0	1	0	0	3	3	2	2	5	3	3	1	5	3	2	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr13:35517144C>G	uc001uvb.2	+	2	393	c.187C>G	c.(187-189)CCT>GCT	p.P63A		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	63						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GATGATTAACCCTTCGGTGCC	0.498													9	16					0	0	0	0	G	35517144	G	G	35517144	3	3	273	1	0	0	0	0	1	0	0	0	10240	623	22	4	189	4	NBEA	13	35517144	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	11571852	35517144	79652734	175	49598											
ZC3H13	23091	broad.mit.edu	37	chr13	46563012	46563012	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cattggagagcgatgtcttgGaggactctgctttctctggg	6	13	14	8	1	3	1	0	0	3	1	4	5	3	3	0	4	2	1	0	4	0	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr13:46563012G>C	uc010tfw.1	-	8	1171	c.1165C>G	c.(1165-1167)CCA>GCA	p.P389A	ZC3H13_uc001vas.1_Missense_Mutation_p.P389A|ZC3H13_uc001vat.1_Missense_Mutation_p.P389A	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	389	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		CGATGTCTTGGAGGACTCTGC	0.493													7	23					0	0	0	0	C	46563012	C	C	46563012	3	2	273	1	0	0	0	0	1	0	0	0	17632	1174	41	2	3565	2	ZC3H13	13	46563012	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	11045868	46563012	68606866	176	49599											
MYO16	23026	broad.mit.edu	37	chr13	109438041	109438041	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatcccattagattatgctgTagaagggacagaatccagct	13	11	9	8	0	0	3	0	0	0	3	2	4	2	4	2	1	2	3	2	1	6	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr13:109438041T>C	uc001vqt.1	+	5	626	c.500T>C	c.(499-501)GTA>GCA	p.V167A	MYO16_uc010agk.1_Missense_Mutation_p.V189A	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	167	ANK 4.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GATTATGCTGTAGAAGGGACA	0.343													21	24					0	0	0	0	C	109438041	C	C	109438041	3	2	273	1	0	0	0	0	1	0	0	0	10117	1638	57	5	514	5	MYO16	13	109438041	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	62875029	109438041	5731837	177	49600											
MCF2L	23263	broad.mit.edu	37	chr13	113748882	113748882	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaggacgacgggggctggtCaagtgcagaggagcagatta	11	6	18	6	2	1	3	1	1	0	2	1	6	1	5	0	5	2	3	0	5	2	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr13:113748882C>G	uc001vsu.2	+	27	3201	c.3179C>G	c.(3178-3180)TCA>TGA	p.S1060*	MCF2L_uc001vsq.2_Nonsense_Mutation_p.S1060*|MCF2L_uc010tjr.1_Nonsense_Mutation_p.S1003*|MCF2L_uc001vsr.2_Nonsense_Mutation_p.S1007*|MCF2L_uc010tjs.1_Nonsense_Mutation_p.S1001*	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	1033					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				GGGGGCTGGTCAAGTGCAGAG	0.632													7	16					0	0	0	0	G	113748882	G	G	113748882	4	3	273	1	0	0	0	0	0	1	0	0	9432	838	29	2	3380	2	MCF2L	13	113748882	Nonsense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	4310841	113748882	1420996	178	49601											
ACIN1	22985	broad.mit.edu	37	chr14	23548865	23548865	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacgagggttggcatgagtaCgtgcctgggctacatctctc	7	10	13	11	2	1	1	0	1	1	0	3	2	1	1	1	3	3	4	1	3	2	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr14:23548865C>T	uc001wit.3	-	6	2181	c.1853G>A	c.(1852-1854)CGT>CAT	p.R618H	ACIN1_uc001wis.3_Missense_Mutation_p.R300H|ACIN1_uc010akg.2_Missense_Mutation_p.R618H|ACIN1_uc010tnj.1_Missense_Mutation_p.R578H	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	618	Ser-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGCATGAGTACGTGCCTGGGC	0.522													25	107					0	0	0	0	T	23548865	T	T	23548865	3	4	273	1	0	0	0	0	1	0	0	0	142	536	19	1	2375	1	ACIN1	14	23548865	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08		23548865	83800675	179	49602											
LRRC16B	90668	broad.mit.edu	37	chr14	24531703	24531703	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacagtgaagtgaagctctCagtcgtcacctacctaacca	12	8	7	14	1	2	2	2	2	1	0	4	2	2	2	4	0	3	1	4	0	4	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr14:24531703C>G	uc001wlj.2	+	28	2652	c.2495C>G	c.(2494-2496)TCA>TGA	p.S832*	LRRC16B_uc001wlk.2_5'UTR	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	832										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		GTGAAGCTCTCAGTCGTCACC	0.572													28	110					0	0	0	0	G	24531703	G	G	24531703	4	3	273	1	0	0	0	0	0	1	0	0	9022	838	29	2	2605	2	LRRC16B	14	24531703	Nonsense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	982838	24531703	82817837	180	49603											
STXBP6	29091	broad.mit.edu	37	chr14	25288333	25288333	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatcgctctccacgctcattCaaggcctggcttgccttctg	6	12	8	15	2	4	0	2	0	2	0	6	0	4	0	3	2	1	3	3	2	2	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr14:25288333C>G	uc001wpu.2	-	5	1234	c.519G>C	c.(517-519)TTG>TTC	p.L173F	STXBP6_uc001wpv.2_Missense_Mutation_p.L173F|STXBP6_uc001wpw.2_Missense_Mutation_p.L173F|STXBP6_uc001wpx.1_RNA|STXBP6_uc001wpt.2_Missense_Mutation_p.L71F	NM_014178	NP_054897	Q8NFX7	STXB6_HUMAN	amisyn	173	v-SNARE coiled-coil homology.				vesicle-mediated transport	cytoplasm|integral to membrane					0				GBM - Glioblastoma multiforme(265;0.0296)		CACGCTCATTCAAGGCCTGGC	0.562													5	88					0	0	0	0	G	25288333	G	G	25288333	3	3	273	1	0	0	0	0	1	0	0	0	15424	825	29	2	121	2	STXBP6	14	25288333	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	756630	25288333	82061207	181	49604											
MUDENG	55745	broad.mit.edu	37	chr14	57749862	57749862	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaaatcaatggaaattagtCtttctggaactgtaactttt	14	15	6	6	0	3	0	1	0	2	0	3	2	3	2	0	2	2	1	0	2	7	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr14:57749862C>T	uc001xcv.2	+	6	1634	c.1207C>T	c.(1207-1209)CTT>TTT	p.L403F	MUDENG_uc010tri.1_Missense_Mutation_p.L157F|MUDENG_uc010trj.1_Missense_Mutation_p.L300F	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	403	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1						GGAAATTAGTCTTTCTGGAAC	0.318													8	39					0	0	0	0	T	57749862	T	T	57749862	3	4	273	1	0	0	0	0	1	0	0	0	10036	913	32	2	1229	2	MUDENG	14	57749862	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	32461529	57749862	49599678	182	49605											
TRMT5	57570	broad.mit.edu	37	chr14	61444232	61444232	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggagataataaaatatacCtttgtcatcatgttctgctc	12	16	6	7	0	3	1	2	0	1	1	4	2	3	1	1	1	2	2	1	1	5	7			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr14:61444232C>A	uc001xff.3	-	3	883	c.792G>T	c.(790-792)AAG>AAT	p.K264N		NM_020810	NP_065861	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	264						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			central_nervous_system(2)|large_intestine(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		TAAAATATACCTTTGTCATCA	0.249													8	64					7.48243e-07	8.25739e-07	1	0	A	61444232	A	A	61444232	3	1	273	1	0	0	0	0	1	0	0	0	16634	695	24	4	749	4	TRMT5	14	61444232	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	3694370	61444232	45905308	183	49606											
SYNE2	23224	broad.mit.edu	37	chr14	64595181	64595181	+	Missense_Mutation	SNP	G	T	T																															atcttacagaatgaaataaaGagattatatcatcagctcat																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr14:64595181G>T	uc001xgm.2	+	74	14159	c.13929G>T	c.(13927-13929)AAG>AAT	p.K4643N	SYNE2_uc001xgl.2_Missense_Mutation_p.K4643N|SYNE2_uc010apy.2_Missense_Mutation_p.K1028N|SYNE2_uc010apz.1_Missense_Mutation_p.K535N	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4643	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATGAAATAAAGAGATTATATC	0.289													7	49					0.000157383	0.000165413	1	0	T	64595181	T	T	64595181	3	4	273	1	0	0	0	0	1	0	0	0	15512	933	33	2	14219	2	SYNE2	14	64595181	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	3150949	64595181	42754359	184	49607	111	2									
SYNE2	23224	broad.mit.edu	37	chr14	64595183	64595183	+	Missense_Mutation	SNP	G	A	A																															cttacagaatgaaataaagaGattatatcatcagctcatta																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr14:64595183G>A	uc001xgm.2	+	74	14161	c.13931G>A	c.(13930-13932)AGA>AAA	p.R4644K	SYNE2_uc001xgl.2_Missense_Mutation_p.R4644K|SYNE2_uc010apy.2_Missense_Mutation_p.R1029K|SYNE2_uc010apz.1_Missense_Mutation_p.R536K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4644	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAAATAAAGAGATTATATCAT	0.294													7	47					0	0	0	0	A	64595183	A	A	64595183	3	1	273	1	0	0	0	0	1	0	0	0	15512	942	33	2	14221	2	SYNE2	14	64595183	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	2	64595183	42754357	185	49608	111	2									
SYNE2	23224	broad.mit.edu	37	chr14	64596835	64596835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagcagccctttcgtcactGagagccagcaagatgctttg	9	10	10	12	1	2	2	2	1	0	2	3	3	2	2	2	0	5	3	2	0	1	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr14:64596835G>A	uc001xgm.2	+	76	14439	c.14209G>A	c.(14209-14211)GAG>AAG	p.E4737K	SYNE2_uc001xgl.2_Missense_Mutation_p.E4737K|SYNE2_uc010apy.2_Missense_Mutation_p.E1122K|SYNE2_uc010apz.1_Missense_Mutation_p.E629K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4737	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTTCGTCACTGAGAGCCAGCA	0.468													4	32					0	0	0	0	A	64596835	A	A	64596835	3	1	273	1	0	0	0	0	1	0	0	0	15512	1291	45	2	14507	2	SYNE2	14	64596835	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1652	64596835	42752705	186	49609											
TTC7B	145567	broad.mit.edu	37	chr14	91142901	91142901	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catactggcctcttcttccaAgagcaatggtgagtaagtca	11	11	9	10	0	3	2	1	1	2	1	4	2	4	2	2	2	2	2	2	2	4	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr14:91142901A>G	uc001xyp.2	-	9	1240	c.1118T>C	c.(1117-1119)CTT>CCT	p.L373P	TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	373	TPR 3.						binding			ovary(2)	2		Melanoma(154;0.222)				TCTTCTTCCAAGAGCAATGGT	0.547													11	68					0	0	0	0	G	91142901	G	G	91142901	3	3	273	1	0	0	0	0	1	0	0	0	16781	72	3	5	1461	5	TTC7B	14	91142901	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	26546066	91142901	16206639	187	49610											
MAGEL2	54551	broad.mit.edu	37	chr15	23890759	23890759	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggagtcatcaatgatttagCggagcccaggggaaaatttg	12	10	13	6	1	2	1	2	1	0	0	2	4	2	4	1	4	2	0	1	4	4	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:23890759C>T	uc001ywj.3	-	1	417	c.322G>A	c.(322-324)GCT>ACT	p.A108T		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		AATGATTTAGCGGAGCCCAGG	0.632													4	7					0	0	0	0	T	23890759	T	T	23890759	3	4	273	1	0	0	0	0	1	0	0	0	9242	768	27	1	1622	1	MAGEL2	15	23890759	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08		23890759	78640633	188	49611											
RYR3	6263	broad.mit.edu	37	chr15	33927944	33927944	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggaggagacatgcgagtcgGctgggcgaggccaggctgtc	7	6	19	9	3	0	1	0	0	0	1	2	5	0	2	1	6	1	2	1	6	0	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:33927944G>A	uc001zhi.2	+	26	3375	c.3305G>A	c.(3304-3306)GGC>GAC	p.G1102D	RYR3_uc010bar.2_Missense_Mutation_p.G1102D	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1102	B30.2/SPRY 2.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATGCGAGTCGGCTGGGCGAGG	0.507													7	14					0	0	0	0	A	33927944	A	A	33927944	3	1	273	1	0	0	0	0	1	0	0	0	13835	1203	42	4	3407	4	RYR3	15	33927944	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	10037185	33927944	68603448	189	49612											
PAK6	56924	broad.mit.edu	37	chr15	40568201	40568201	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagagagccacagcccaggAgctcctagaccaccccttcc	11	4	9	17	0	0	3	0	0	0	3	2	5	2	4	7	1	3	1	7	1	1	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:40568201A>T	uc010bbl.2	+	11	2392	c.1952A>T	c.(1951-1953)GAG>GTG	p.E651V	PAK6_uc010bbm.2_Missense_Mutation_p.E651V|PAK6_uc001zky.3_Missense_Mutation_p.E606V|PAK6_uc010bbn.2_Missense_Mutation_p.E651V|PAK6_uc001zlb.2_Missense_Mutation_p.E651V	NM_001128628	NP_001122100	Q9NQU5	PAK6_HUMAN	p21-activated kinase 6	651	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(5)|large_intestine(1)|ovary(1)|skin(1)	8		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		ACAGCCCAGGAGCTCCTAGAC	0.627													17	57					0	0	0	0	T	40568201	T	T	40568201	3	4	273	1	0	0	0	0	1	0	0	0	11458	304	11	5	1982	5	PAK6	15	40568201	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	6640257	40568201	61963191	190	49613											
UBR1	197131	broad.mit.edu	37	chr15	43346982	43346982	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atactcttcccaatttgtccTggctataaccctggaagttg	9	14	7	11	0	1	0	0	0	1	0	3	1	3	1	3	2	2	2	3	2	5	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:43346982T>A	uc001zqq.2	-	12	1463	c.1397A>T	c.(1396-1398)CAG>CTG	p.Q466L	UBR1_uc010udk.1_Missense_Mutation_p.Q466L	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	466					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		CAATTTGTCCTGGCTATAACC	0.388													29	49					0	0	0	0	A	43346982	A	A	43346982	3	1	273	1	0	0	0	0	1	0	0	0	16969	1580	55	5	3996	5	UBR1	15	43346982	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	2778781	43346982	59184410	191	49614											
DUOX1	53905	broad.mit.edu	37	chr15	45455880	45455880	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttcgacctcaggaccactAtgctggtatgtcagggccca	9	9	11	12	1	2	0	2	0	0	0	3	2	2	1	3	3	1	3	3	3	2	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:45455880A>G	uc001zus.1	+	33	4745	c.4399A>G	c.(4399-4401)ATG>GTG	p.M1467V	DUOX1_uc001zut.1_Missense_Mutation_p.M1467V|DUOX1_uc010bee.1_Missense_Mutation_p.M847V	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	1467	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CAGGACCACTATGCTGGTATG	0.562											OREG0023103	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	69					0	0	0	0	G	45455880	G	G	45455880	3	3	273	1	0	0	0	0	1	0	0	0	4822	449	16	5	4521	5	DUOX1	15	45455880	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	2108898	45455880	57075512	192	49615											
MYO5C	55930	broad.mit.edu	37	chr15	52531989	52531989	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtaagctgaatattaagcaCgaatcgtcggatactctgga	14	10	10	7	3	1	1	0	1	1	0	3	4	1	3	0	2	3	3	0	2	6	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:52531989C>A	uc010bff.2	-	21	2781	c.2644G>T	c.(2644-2646)GTG>TTG	p.V882L	MYO5C_uc010uga.1_RNA|MYO5C_uc010ugb.1_Intron	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	882	IQ 5.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		ATATTAAGCACGAATCGTCGG	0.438													13	60					2.27111e-07	2.52436e-07	1	0	A	52531989	A	A	52531989	3	1	273	1	0	0	0	0	1	0	0	0	10133	536	19	3	2668	3	MYO5C	15	52531989	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	7076109	52531989	49999403	193	49616											
CCPG1	9236	broad.mit.edu	37	chr15	55677908	55677908	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcaacatttctatatctGacccctaaggaaaagtgata	16	12	5	8	0	3	2	1	2	2	0	3	3	3	3	2	1	1	0	2	1	8	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:55677908G>T	uc002acv.1	-	3	230	c.65C>A	c.(64-66)TCA>TAA	p.S22*	CCPG1_uc002acy.2_Nonsense_Mutation_p.S22*|DYX1C1_uc010ugh.1_RNA|CCPG1_uc002acw.1_5'UTR|CCPG1_uc002acx.2_Nonsense_Mutation_p.S22*|CCPG1_uc010bfk.1_Nonsense_Mutation_p.S22*|CCPG1_uc002acz.1_Nonsense_Mutation_p.S22*	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	22	Cytoplasmic (Potential).|Interaction with MCF2L and SRC (By similarity).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		TTCTATATCTGACCCCTAAGG	0.403													9	14					1.12685e-05	1.21747e-05	1	0	T	55677908	T	T	55677908	4	4	273	1	0	0	0	0	0	1	0	0	2953	1294	45	2	2232	2	CCPG1	15	55677908	Nonsense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	3145919	55677908	46853484	194	49617											
VPS13C	54832	broad.mit.edu	37	chr15	62254026	62254026	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcacacttgtggcagcccTttctgcagcctgggcagtgg	5	12	12	12	0	2	0	1	0	1	0	2	0	2	0	2	3	3	3	2	3	0	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:62254026T>C	uc002agz.2	-	35	3744	c.3670A>G	c.(3670-3672)AGG>GGG	p.R1224G	VPS13C_uc002aha.2_Missense_Mutation_p.R1181G|VPS13C_uc002ahb.1_Missense_Mutation_p.R1224G|VPS13C_uc002ahc.1_Missense_Mutation_p.R1181G	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1224					protein localization					ovary(2)	2						GTGGCAGCCCTTTCTGCAGCC	0.438													19	54					0	0	0	0	C	62254026	C	C	62254026	3	2	273	1	0	0	0	0	1	0	0	0	17259	1608	56	5	7823	5	VPS13C	15	62254026	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	6576118	62254026	40277366	195	49618											
CILP	8483	broad.mit.edu	37	chr15	65490630	65490630	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctctgaggtgacctcatctCtgaagtccacagagaacatg	11	9	10	11	0	3	4	1	3	2	1	5	5	4	4	2	1	1	1	2	1	2	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:65490630C>G	uc002aon.2	-	9	2175	c.1994G>C	c.(1993-1995)AGA>ACA	p.R665T		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	665					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						GACCTCATCTCTGAAGTCCAC	0.512													14	58					0	0	0	0	G	65490630	G	G	65490630	3	3	273	1	0	0	0	0	1	0	0	0	3444	913	32	2	1564	2	CILP	15	65490630	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	3236604	65490630	37040762	196	49619											
LRRC49	54839	broad.mit.edu	37	chr15	71197029	71197029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggatttatatgataaccaGattgaagaaattagtgggct	14	14	10	3	0	0	4	0	2	0	2	0	5	0	5	1	2	1	1	1	2	6	7			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:71197029G>C	uc002asw.2	+	5	682	c.435G>C	c.(433-435)CAG>CAC	p.Q145H	LRRC49_uc002asu.2_Missense_Mutation_p.Q135H|LRRC49_uc002asx.2_Missense_Mutation_p.Q101H|LRRC49_uc010ukf.1_Missense_Mutation_p.Q150H|LRRC49_uc002asy.2_5'UTR|LRRC49_uc002asz.2_Missense_Mutation_p.Q117H	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	145	LRR 2.					cytoplasm|microtubule				ovary(1)	1						ATGATAACCAGATTGAAGAAA	0.348													32	99					0	0	0	0	C	71197029	C	C	71197029	3	2	273	1	0	0	0	0	1	0	0	0	9056	933	33	2	453	2	LRRC49	15	71197029	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	5706399	71197029	31334363	197	49620											
C15orf39	56905	broad.mit.edu	37	chr15	75501034	75501034	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccacgctgtcggaggagcGggcactgcgggagctcgccc	6	4	16	15	5	0	0	0	0	0	0	2	3	0	3	2	4	3	3	2	4	0	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:75501034G>A	uc002azp.3	+	2	2965	c.2645G>A	c.(2644-2646)CGG>CAG	p.R882Q	C15orf39_uc002azq.3_Missense_Mutation_p.R882Q|C15orf39_uc002azr.3_Missense_Mutation_p.R280Q	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	882											0						TCGGAGGAGCGGGCACTGCGG	0.672													5	9					0	0	0	0	A	75501034	A	A	75501034	3	1	273	1	0	0	0	0	1	0	0	0	1799	1116	39	1	2647	1	C15orf39	15	75501034	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	4304005	75501034	27030358	198	49621											
IL16	3603	broad.mit.edu	37	chr15	81575048	81575048	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgcatctctggcattttcGtccacacgctgtcaccagga	9	11	8	13	2	2	0	1	0	1	0	5	1	3	1	2	2	1	3	2	2	1	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:81575048G>A	uc002bgh.3	+	9	1526	c.1150G>A	c.(1150-1152)GTC>ATC	p.V384I	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.V384I|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.V426I|IL16_uc002bgg.2_Missense_Mutation_p.V384I|IL16_uc002bgi.1_5'UTR	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	384	PDZ 2.|Interaction with GRIN2A.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						TGGCATTTTCGTCCACACGCT	0.597													34	123					0	0	0	0	A	81575048	A	A	81575048	3	1	273	1	0	0	0	0	1	0	0	0	7672	1145	40	1	1180	1	IL16	15	81575048	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	6074014	81575048	20956344	199	49622											
BNC1	646	broad.mit.edu	37	chr15	83926268	83926268	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgtgtctgtttcgactgcGaacagacgaaaacatggtgt	10	11	12	8	3	1	1	0	0	1	1	2	4	1	1	0	1	3	2	0	1	3	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:83926268G>A	uc002bjt.1	-	5	2999	c.2911C>T	c.(2911-2913)CGC>TGC	p.R971C	BNC1_uc010uos.1_Missense_Mutation_p.R959C	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	971	C2H2-type 6.				epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TTTCGACTGCGAACAGACGAA	0.507													59	45					0	0	0	0	A	83926268	A	A	83926268	3	1	273	1	0	0	0	0	1	0	0	0	1477	1058	37	1	77	1	BNC1	15	83926268	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	2351220	83926268	18605124	200	49623											
AKAP13	11214	broad.mit.edu	37	chr15	86286764	86286764	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgatgaggatcccatcgttCttccccagtcctgaggagcc	7	10	10	14	1	1	3	0	3	1	0	5	5	4	5	5	2	1	1	5	2	0	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr15:86286764C>G	uc002blv.1	+	36	8270	c.8100C>G	c.(8098-8100)TTC>TTG	p.F2700L	AKAP13_uc002blu.1_Missense_Mutation_p.F2704L|AKAP13_uc002blw.1_Missense_Mutation_p.F1165L|AKAP13_uc002blx.1_Missense_Mutation_p.F945L	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2700	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						TCCCATCGTTCTTCCCCAGTC	0.517													8	58					0	0	0	0	G	86286764	G	G	86286764	3	3	273	1	0	0	0	0	1	0	0	0	449	912	32	2	8308	2	AKAP13	15	86286764	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	2360496	86286764	16244628	201	49624											
CLCN7	1186	broad.mit.edu	37	chr16	1498432	1498432	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgctcagcacgtccacaatgAcgccgaccttctcacgccgc	8	6	8	19	6	2	1	2	1	1	0	4	2	3	1	4	0	1	2	4	0	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:1498432A>T	uc002clv.2	-	21	2047	c.1937T>A	c.(1936-1938)GTC>GAC	p.V646D	CLCN7_uc010brq.1_Missense_Mutation_p.V16D|CLCN7_uc002clu.2_Missense_Mutation_p.V94D|CLCN7_uc002clw.2_Missense_Mutation_p.V622D	NM_001287	NP_001278	P51798	CLCN7_HUMAN	chloride channel 7 isoform a	646	Cytoplasmic (By similarity).|CBS 1.					integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Hepatocellular(780;0.0893)				GTCCACAATGACGCCGACCTT	0.652													12	24					0	0	0	0	T	1498432	T	T	1498432	3	4	273	1	0	0	0	0	1	0	0	0	3483	275	10	5	500	5	CLCN7	16	1498432	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08		1498432	88856321	202	49625											
NTN3	4917	broad.mit.edu	37	chr16	2522335	2522335	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctggacagcagcccagtgctCcaagactgggtgaccgccac	9	5	12	15	1	0	2	0	1	0	1	1	3	1	3	4	2	3	2	4	2	1	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:2522335C>G	uc002cqj.2	+	1	836	c.633C>G	c.(631-633)CTC>CTG	p.L211L	TBC1D24_uc002cqk.2_5'Flank|TBC1D24_uc002cql.2_5'Flank	NM_006181	NP_006172	O00634	NET3_HUMAN	netrin 3 precursor	211	Laminin N-terminal.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				central_nervous_system(1)	1						GCCCAGTGCTCCAAGACTGGG	0.672													4	22					0	0	0	0	G	2522335	G	G	2522335	2	3	273	1	0	0	0	0	0	0	0	1	10755	842	30	2		2	NTN3	16	2522335	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1023903	2522335	87832418	203	49626											
IQCK	124152	broad.mit.edu	37	chr16	19838428	19838428	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcacattcaccagcaagtCaaaattttctgggccaagca	15	8	7	11	0	3	0	2	0	1	0	3	0	3	0	2	1	3	3	2	1	5	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:19838428C>T	uc002dgr.2	+	9	1470	c.771C>T	c.(769-771)GTC>GTT	p.V257V	IQCK_uc002dgs.2_RNA|IQCK_uc010vat.1_Missense_Mutation_p.S229L|IQCK_uc010bwc.2_RNA|IQCK_uc010vau.1_Silent_p.V169V	NM_153208	NP_694940	Q8N0W5	IQCK_HUMAN	IQ motif containing K	257										skin(1)	1						ACCAGCAAGTCAAAATTTTCT	0.443													7	40					0	0	0	0	T	19838428	T	T	19838428	2	4	273	1	0	0	0	0	0	0	0	1	7852	813	29	2		2	IQCK	16	19838428	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	17316093	19838428	70516325	204	49627											
LCMT1	51451	broad.mit.edu	37	chr16	25175987	25175987	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagcagtccgcaaacctccTgaagtgggcagccaacagtt	12	6	11	12	1	0	2	0	1	0	1	2	2	2	2	4	1	4	4	4	1	3	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:25175987T>A	uc002dnx.1	+	7	796	c.638T>A	c.(637-639)CTG>CAG	p.L213Q	LCMT1_uc002dny.1_Missense_Mutation_p.L158Q|LCMT1_uc002dnz.1_Missense_Mutation_p.L113Q|LCMT1_uc002doa.1_Missense_Mutation_p.L58Q	NM_016309	NP_057393	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1 isoform a	213							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity				0				GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	GCAAACCTCCTGAAGTGGGCA	0.448													9	44					0	0	0	0	A	25175987	A	A	25175987	3	1	273	1	0	0	0	0	1	0	0	0	8718	1580	55	5	664	5	LCMT1	16	25175987	Missense_Mutation	SNP	T	TCGA-CX-7086-01A-11D-2078-08	5337559	25175987	65178766	205	49628											
IL4R	3566	broad.mit.edu	37	chr16	27363876	27363876	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagttcagaatctataacGtgacctacctagaaccctcc	13	9	5	14	1	2	3	1	1	1	2	3	3	3	3	5	0	3	1	5	0	6	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:27363876G>A	uc002don.2	+	7	771	c.529G>A	c.(529-531)GTG>ATG	p.V177M	IL4R_uc002dom.2_Missense_Mutation_p.V177M|IL4R_uc002dop.3_Missense_Mutation_p.V162M|IL4R_uc010bxy.2_Missense_Mutation_p.V177M|IL4R_uc002doo.2_Missense_Mutation_p.V17M	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	177	Extracellular (Potential).|Fibronectin type-III.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						AATCTATAACGTGACCTACCT	0.592													18	60					0	0	0	0	A	27363876	A	A	27363876	3	1	273	1	0	0	0	0	1	0	0	0	7737	1145	40	1	547	1	IL4R	16	27363876	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	2187889	27363876	62990877	206	49629											
ATXN2L	11273	broad.mit.edu	37	chr16	28847379	28847379	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccaaggcgcggtgccccaGagtggggtgcctgcactctc	5	6	14	16	2	1	1	0	0	1	1	2	1	1	1	5	4	3	1	5	4	1	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:28847379G>A	uc002drc.2	+	22	3189	c.3021G>A	c.(3019-3021)CAG>CAA	p.Q1007Q	uc010vct.1_Intron|ATXN2L_uc002drb.2_Silent_p.Q1007Q|ATXN2L_uc002dqy.2_Silent_p.Q1007Q|ATXN2L_uc002dra.2_Silent_p.Q1007Q|ATXN2L_uc002dqz.2_Silent_p.Q1007Q|ATXN2L_uc010vdb.1_Silent_p.Q1013Q|ATXN2L_uc002dre.2_Silent_p.Q1007Q|ATXN2L_uc002drf.2_Silent_p.Q416Q|ATXN2L_uc002drg.2_Silent_p.Q290Q	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	1007						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CGGTGCCCCAGAGTGGGGTGC	0.706													23	91					0	0	0	0	A	28847379	A	A	28847379	2	1	273	1	0	0	0	0	0	0	0	1	1214	933	33	2		2	ATXN2L	16	28847379	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1483503	28847379	61507374	207	49630											
TOX3	27324	broad.mit.edu	37	chr16	52473778	52473778	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctgacactgttccatgttGagacagtggagtgttgagaa	10	12	13	6	0	0	3	0	3	0	2	1	6	1	4	1	1	1	4	1	1	1	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:52473778G>A	uc002egw.2	-	7	1261	c.1090C>T	c.(1090-1092)CAA>TAA	p.Q364*	TOX3_uc010vgt.1_Nonsense_Mutation_p.Q359*|TOX3_uc010vgu.1_Nonsense_Mutation_p.Q364*	NM_001080430	NP_001073899	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	364					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity				0						GTTCCATGTTGAGACAGTGGA	0.527													12	75					0	0	0	0	A	52473778	A	A	52473778	4	1	273	1	0	0	0	0	0	1	0	0	16446	1299	45	2	644	2	TOX3	16	52473778	Nonsense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	23626399	52473778	37880975	208	49631											
CNOT1	23019	broad.mit.edu	37	chr16	58589282	58589282	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaagtgaccagtcctttctCaattataccaccaaataggc	13	11	6	11	0	1	1	1	1	1	0	3	1	2	1	4	1	1	1	4	1	6	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:58589282C>T	uc002env.2	-	21	3057	c.2764G>A	c.(2764-2766)GAG>AAG	p.E922K	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.E917K|CNOT1_uc002enx.2_Missense_Mutation_p.E922K|CNOT1_uc002enz.1_Missense_Mutation_p.E351K	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	922				E -> G (in Ref. 1; ABQ66268).	nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AGTCCTTTCTCAATTATACCA	0.388													28	90					0	0	0	0	T	58589282	T	T	58589282	3	4	273	1	0	0	0	0	1	0	0	0	3632	835	29	2	4704	2	CNOT1	16	58589282	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	6115504	58589282	31765471	209	49632											
HSF4	3299	broad.mit.edu	37	chr16	67203679	67203679	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgggcccggaagccagtccCtccccctaagaccccgcgcc	6	5	10	20	3	0	1	0	0	0	1	2	2	2	2	8	2	1	0	8	2	2	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:67203679C>T	uc002erl.1	+	15	2435	c.1470C>T	c.(1468-1470)CCC>CCT	p.P490P	HSF4_uc002erm.1_Silent_p.P460P|HSF4_uc002ern.1_RNA|HSF4_uc010cec.1_RNA|NOL3_uc010vjc.1_5'Flank	NM_001040667	NP_001035757	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4 isoform b	490					response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		AAGCCAGTCCCTCCCCCTAAG	0.662											OREG0023873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	47					0	0	0	0	T	67203679	T	T	67203679	2	4	273	1	0	0	0	0	0	0	0	1	7437	668	24	4		4	HSF4	16	67203679	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	8614397	67203679	23151074	210	49633											
FAM65A	79567	broad.mit.edu	37	chr16	67574260	67574260	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgggcgagtttcatctccgaAtgaaaggtactgagttgtgg	9	12	14	6	2	2	2	1	2	1	0	3	4	2	2	1	3	1	3	1	3	3	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:67574260A>G	uc010vjp.1	+	8	781	c.685A>G	c.(685-687)ATG>GTG	p.M229V	FAM65A_uc010cei.1_Missense_Mutation_p.M51V|FAM65A_uc002eth.2_Missense_Mutation_p.M209V|FAM65A_uc010cej.2_Missense_Mutation_p.M212V|FAM65A_uc002eti.1_Missense_Mutation_p.M172V|FAM65A_uc010vjq.1_Missense_Mutation_p.M223V|FAM65A_uc002etj.1_Missense_Mutation_p.M208V|FAM65A_uc002etk.2_Missense_Mutation_p.M208V	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	213						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		TCATCTCCGAATGAAAGGTAC	0.612													15	40					0	0	0	0	G	67574260	G	G	67574260	3	3	273	1	0	0	0	0	1	0	0	0	5631	101	4	5	651	5	FAM65A	16	67574260	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	370581	67574260	22780493	211	49634											
SF3B3	23450	broad.mit.edu	37	chr16	70575647	70575647	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcagccatgcctctggaagaAggagacacattcttttttca	11	12	8	10	0	4	2	2	0	2	2	4	4	4	3	2	2	2	0	2	2	2	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr16:70575647A>G	uc002ezf.2	+	9	1354	c.1143A>G	c.(1141-1143)GAA>GAG	p.E381E		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	381					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				CTCTGGAAGAAGGAGACACAT	0.448													36	99					0	0	0	0	G	70575647	G	G	70575647	2	3	273	1	0	0	0	0	0	0	0	1	14217	69	3	5		5	SF3B3	16	70575647	Silent	SNP	A	TCGA-CX-7086-01A-11D-2078-08	3001387	70575647	19779106	212	49635											
TP53	7157	broad.mit.edu	37	chr17	7577062	7577062	+	Frame_Shift_Del	DEL	T	-	-																															agctcgtggtgaggctccccTttcttgcggagattctcttc																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr17:7577062delT	uc002gim.2	-	8	1070	c.876delA	c.(874-876)AAAfs	p.K292fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.K292fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.K160fs|TP53_uc010cng.1_Frame_Shift_Del_p.K160fs|TP53_uc002gii.1_Frame_Shift_Del_p.K160fs|TP53_uc010cnh.1_Frame_Shift_Del_p.K292fs|TP53_uc010cni.1_Frame_Shift_Del_p.K292fs|TP53_uc002gij.2_Frame_Shift_Del_p.K292fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	292	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> Q (in a sporadic cancer; somatic mutation).|K -> G (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> T (in sporadic cancers; somatic mutation).|K -> R (in sporadic cancers; somatic mutation).|K -> E (in sporadic cancers; somatic mutation).|K -> I (in LFS; germline mutation and in a sporadic cancer; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).	KK->RR: Abolishes polyubiquitination by MKRN1.	activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K291fs*48(8)|p.0?(7)|p.K292R(5)|p.K292T(4)|p.G293fs*13(3)|p.K292N(3)|p.?(2)|p.K292E(2)|p.K292fs*13(1)|p.T284_G293del10(1)|p.L265_K305del41(1)|p.R290fs*12(1)|p.R290fs*50(1)|p.R290_P295>X(1)|p.K292K(1)|p.K292*(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGCTCCCCTTTCTTGCGGA	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7577062	-	-	7577062	7	5	273	1	0	1	0	1	0	0	0	0	16448	1606	56	0	410	0	TP53	17	7577062	Frame_Shift_Del	DEL	T	TCGA-CX-7086-01A-11D-2078-08		7577062	73618148	213	49636											
SSH2	85464	broad.mit.edu	37	chr17	27963169	27963169	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgggaaaaagatcgtgaccgGgtttcttgggagagctccac	10	9	14	8	2	1	3	0	1	1	2	3	5	2	4	2	3	1	2	2	3	2	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr17:27963169G>A	uc002heo.1	-	14	1998	c.1998C>T	c.(1996-1998)ACC>ACT	p.T666T	SSH2_uc010wbh.1_Silent_p.T693T	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	666					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						ATCGTGACCGGGTTTCTTGGG	0.493													42	54					0	0	0	0	A	27963169	A	A	27963169	2	1	273	1	0	0	0	0	0	0	0	1	15251	1219	43	4		4	SSH2	17	27963169	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	20386107	27963169	53232041	214	49637											
EFCAB5	374786	broad.mit.edu	37	chr17	28296203	28296203	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgttaactcaagtagaaaaGaagaaggttttgacagaagc	18	9	10	4	0	1	5	1	1	0	4	1	5	1	5	0	1	2	3	0	1	8	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr17:28296203G>A	uc002het.2	+	4	777	c.585G>A	c.(583-585)AAG>AAA	p.K195K	EFCAB5_uc010wbi.1_Intron|EFCAB5_uc010wbj.1_Silent_p.K139K|EFCAB5_uc010wbk.1_Intron|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Silent_p.K74K|EFCAB5_uc010csf.2_Silent_p.K74K	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	195							calcium ion binding			ovary(1)|skin(1)	2						AAGTAGAAAAGAAGAAGGTTT	0.343													7	27					0	0	0	0	A	28296203	A	A	28296203	2	1	273	1	0	0	0	0	0	0	0	1	4960	933	33	2		2	EFCAB5	17	28296203	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	333034	28296203	52899007	215	49638											
C17orf53	78995	broad.mit.edu	37	chr17	42228331	42228331	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttccctcccctcttagcaGagtgggagaagtctggagga	8	9	12	12	0	2	2	0	0	2	2	4	5	4	4	4	3	1	1	4	3	2	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr17:42228331G>A	uc002ifi.1	+	4	1412	c.1227G>A	c.(1225-1227)CAG>CAA	p.Q409Q	C17orf53_uc010czq.1_Silent_p.Q409Q|C17orf53_uc002ifj.1_Intron|C17orf53_uc002ifk.1_Intron	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	409											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CCTCTTAGCAGAGTGGGAGAA	0.453													3	20					0	0	0	0	A	42228331	A	A	42228331	2	1	273	1	0	0	0	0	0	0	0	1	1869	933	33	2		2	C17orf53	17	42228331	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	13932128	42228331	38966879	216	49639											
B4GALNT2	124872	broad.mit.edu	37	chr17	47241498	47241498	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctaccaagactttcctccGcccccacaagctcatgatca	10	9	5	17	1	2	2	2	1	0	1	4	2	4	2	5	0	3	2	5	0	3	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr17:47241498G>A	uc002ion.2	+	8	1054	c.995G>A	c.(994-996)CGC>CAC	p.R332H	B4GALNT2_uc010wlt.1_Missense_Mutation_p.R246H|B4GALNT2_uc010wlu.1_Missense_Mutation_p.R272H	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	332	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			ACTTTCCTCCGCCCCCACAAG	0.502													60	97					0	0	0	0	A	47241498	A	A	47241498	3	1	273	1	0	0	0	0	1	0	0	0	1269	1087	38	1	1043	1	B4GALNT2	17	47241498	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	5013167	47241498	33953712	217	49640											
GPR142	350383	broad.mit.edu	37	chr17	72367969	72367969	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcctcggatatcatcatcCaggtggtcatcgtgttcgcg	7	11	11	12	4	3	0	3	0	0	0	7	1	4	1	2	3	1	1	2	3	1	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr17:72367969C>T	uc010wqy.1	+	4	619	c.619C>T	c.(619-621)CAG>TAG	p.Q207*	GPR142_uc010wqx.1_Nonsense_Mutation_p.Q119*	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	207	Helical; Name=2; (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TATCATCATCCAGGTGGTCAT	0.657													10	11					0	0	0	0	T	72367969	T	T	72367969	4	4	273	1	0	0	0	0	0	1	0	0	6688	595	21	4	633	4	GPR142	17	72367969	Nonsense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	25126471	72367969	8827241	218	49641											
THOC4	10189	broad.mit.edu	37	chr17	79846187	79846187	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gctgctttgaattcctgccgGcacctctgcctcttccacgg	4	12	9	16	2	2	1	0	1	2	0	4	1	4	1	5	2	3	3	5	2	1	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr17:79846187G>A	uc002kbu.2	-	5	716	c.710C>T	c.(709-711)GCC>GTC	p.A237V		NM_005782	NP_005773	Q86V81	THOC4_HUMAN	THO complex 4	230	Ala/Arg/Gly-rich.				intronless viral mRNA export from host nucleus|mRNA 3'-end processing|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear speck|transcription export complex	nucleotide binding|protein binding|RNA binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			ATTCCTGCCGGCACCTCTGCC	0.647													16	14					0	0	0	0	A	79846187	A	A	79846187	3	1	273	1	0	0	0	0	1	0	0	0	15933	1203	42	4	92	4	THOC4	17	79846187	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	7478218	79846187	1349023	219	49642											
ESCO1	114799	broad.mit.edu	37	chr18	19153946	19153946	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccagctcattatcactttGttcaggcactgatggctgtg	7	14	9	11	0	3	1	3	1	0	0	4	1	4	1	1	2	1	4	1	2	1	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr18:19153946G>C	uc002kth.1	-	4	1793	c.859C>G	c.(859-861)CAA>GAA	p.Q287E	ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1	287					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						TTATCACTTTGTTCAGGCACT	0.423													23	59					0	0	0	0	C	19153946	C	C	19153946	3	2	273	1	0	0	0	0	1	0	0	0	5272	1386	48	4	1699	4	ESCO1	18	19153946	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08		19153946	58923302	220	49643											
UHRF1	29128	broad.mit.edu	37	chr19	4960672	4960672	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgtgtcttacaggactGcctggacagatcctttcggg	6	12	12	11	1	1	1	0	0	1	1	3	3	2	3	2	3	3	1	2	3	1	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:4960672G>A	uc002mbo.2	+	19	2408	c.2240G>A	c.(2239-2241)TGC>TAC	p.C747Y	UHRF1_uc010xik.1_RNA|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.C760Y	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	747	RING-type.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		TTACAGGACTGCCTGGACAGA	0.597													6	18					0	0	0	0	A	4960672	A	A	4960672	3	1	273	1	0	0	0	0	1	0	0	0	17035	1319	46	4	2340	4	UHRF1	19	4960672	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08		4960672	54168311	221	49644											
MUC16	94025	broad.mit.edu	37	chr19	9047546	9047546	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aataattaggggttgtcctgGgaactgttgtgctggtgact	8	14	14	5	0	0	1	0	1	0	0	1	2	1	2	1	4	2	3	1	4	4	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:9047546G>A	uc002mkp.2	-	5	34289	c.34085C>T	c.(34084-34086)CCC>CTC	p.P11362L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11364	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTTGTCCTGGGAACTGTTGT	0.488													33	149					0	0	0	0	A	9047546	A	A	9047546	3	1	273	1	0	0	0	0	1	0	0	0	10026	1232	43	4	9758	4	MUC16	19	9047546	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	4086874	9047546	50081437	222	49645											
MUC16	94025	broad.mit.edu	37	chr19	9049324	9049324	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctgtgcttcaggatgggtGactaatgaggctatcgtctt	7	14	13	7	1	3	2	1	2	2	0	4	3	3	3	0	3	1	2	0	3	2	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:9049324G>A	uc002mkp.2	-	5	32511	c.32307C>T	c.(32305-32307)GTC>GTT	p.V10769V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10771	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGGATGGGTGACTAATGAGG	0.483													14	97					0	0	0	0	A	9049324	A	A	9049324	2	1	273	1	0	0	0	0	0	0	0	1	10026	1277	45	2		2	MUC16	19	9049324	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1778	9049324	50079659	223	49646											
OR7A5	26659	broad.mit.edu	37	chr19	14938380	14938380	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagctgatgagattgcatgtAtggaagaaattatcttagag	14	12	12	3	0	1	4	0	2	1	3	1	7	1	5	0	1	2	3	0	1	5	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:14938380A>G	uc002mzw.2	-	1	897	c.674T>C	c.(673-675)ATA>ACA	p.I225T	OR7A5_uc010xoa.1_Missense_Mutation_p.I225T	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						GATTGCATGTATGGAAGAAAT	0.443													16	62					0	0	0	0	G	14938380	G	G	14938380	3	3	273	1	0	0	0	0	1	0	0	0	11270	449	16	5	289	5	OR7A5	19	14938380	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	5889056	14938380	44190603	224	49647											
BRD4	23476	broad.mit.edu	37	chr19	15349769	15349769	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccgccgggcctgctccaGcgcatcctcgtcctctcggc	2	7	12	20	5	1	0	0	0	1	0	6	0	4	0	6	3	2	2	6	3	0	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:15349769G>A	uc002nar.2	-	19	4027	c.3805C>T	c.(3805-3807)CTG>TTG	p.L1269L		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	1269					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GCCTGCTCCAGCGCATCCTCG	0.512			T	NUT|C15orf55	lethal midline carcinoma of young people								3	7					0	0	0	0	A	15349769	A	A	15349769	2	1	273	1	0	0	0	0	0	0	0	1	1509	962	34	4		4	BRD4	19	15349769	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	411389	15349769	43779214	225	49648											
BRD4	23476	broad.mit.edu	37	chr19	15350615	15350615	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggggctggggctggaccacGgaggcagcacgcagctcctg	7	4	18	12	2	0	0	0	0	0	0	1	2	1	2	2	7	2	6	2	7	0	0			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:15350615G>A	uc002nar.2	-	16	3522	c.3300C>T	c.(3298-3300)TCC>TCT	p.S1100S		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	1100					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GCTGGACCACGGAGGCAGCAC	0.706			T	NUT|C15orf55	lethal midline carcinoma of young people								21	38					0	0	0	0	A	15350615	A	A	15350615	2	1	273	1	0	0	0	0	0	0	0	1	1509	1103	39	1		1	BRD4	19	15350615	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	846	15350615	43778368	226	49649											
GRAMD1A	57655	broad.mit.edu	37	chr19	35516979	35516979	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctcgctggagaagctgcaCcaaggcatcacagtctcaga	11	8	10	12	1	3	2	2	0	2	2	5	3	3	2	1	2	2	4	1	2	2	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:35516979C>T	uc010xse.1	+	20	2246	c.2109C>T	c.(2107-2109)CAC>CAT	p.H703H	GRAMD1A_uc002nxk.2_Silent_p.H692H|GRAMD1A_uc002nxl.2_Silent_p.H465H|GRAMD1A_uc010xsf.1_Silent_p.H704H|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Silent_p.H314H	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	703						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			AGAAGCTGCACCAAGGCATCA	0.647													7	25					0	0	0	0	T	35516979	T	T	35516979	2	4	273	1	0	0	0	0	0	0	0	1	6786	506	18	4		4	GRAMD1A	19	35516979	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	20166364	35516979	23612004	227	49650											
IL28A	282616	broad.mit.edu	37	chr19	39760455	39760455	+	Frame_Shift_Del	DEL	A	-	-																															taccggctccaggaggccccAaaaaaggtgagtgacccggg																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:39760455delA	uc002oku.1	+	5	550	c.498delA	c.(496-498)CCAfs	p.P166fs		NM_172138	NP_742150	Q8IZJ0	IL28A_HUMAN	interleukin 28A precursor	166					response to virus	extracellular space	cytokine activity			ovary(1)|skin(1)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;5.39e-26)|all cancers(26;4.1e-23)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			AGGAGGCCCCAAAAAAGGTGA	0.677													---	---	---								-	39760455	-	-	39760455	7	5	273	1	0	1	0	1	0	0	0	0	7721	117	5	0	516	0	IL28A	19	39760455	Frame_Shift_Del	DEL	A	TCGA-CX-7086-01A-11D-2078-08	4243476	39760455	19368528	228	49651											
SUPT5H	6829	broad.mit.edu	37	chr19	39957129	39957129	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgctcaggtggactacGtggagcccagccagaacacc	9	5	12	15	1	1	1	1	0	0	1	1	3	1	3	4	3	5	1	4	3	2	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:39957129G>A	uc002olo.3	+	12	1065	c.886G>A	c.(886-888)GTG>ATG	p.V296M	SUPT5H_uc002olp.3_Missense_Mutation_p.V296M|SUPT5H_uc002olq.3_Missense_Mutation_p.V292M|SUPT5H_uc002oln.3_Missense_Mutation_p.V296M|SUPT5H_uc002olr.3_Missense_Mutation_p.V296M|SUPT5H_uc002ols.1_5'Flank	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	296	KOW 1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGTGGACTACGTGGAGCCCAG	0.592													13	26					0	0	0	0	A	39957129	A	A	39957129	3	1	273	1	0	0	0	0	1	0	0	0	15465	1145	40	1	928	1	SUPT5H	19	39957129	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	196674	39957129	19171854	229	49652											
TOMM40	10452	broad.mit.edu	37	chr19	45395690	45395690	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggtgtcaagctcacagtCaacaaagggttgagtaacca	14	7	12	8	0	3	1	3	1	0	0	3	2	3	1	1	2	3	3	1	2	4	2	rs142332544	by1000genomes	TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:45395690C>A	uc002ozx.3	+	3	416	c.315C>A	c.(313-315)GTC>GTA	p.V105V	TOMM40_uc002ozy.3_Silent_p.V105V|TOMM40_uc002paa.3_Silent_p.V105V|TOMM40_uc002ozz.2_Silent_p.V105V	NM_006114	NP_006105	O96008	TOM40_HUMAN	translocase of outer mitochondrial membrane 40	105					protein targeting to mitochondrion	integral to membrane of membrane fraction|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex|pore complex	porin activity|protein transmembrane transporter activity|voltage-gated anion channel activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)			OV - Ovarian serous cystadenocarcinoma(262;0.0033)|Epithelial(262;0.176)		AGCTCACAGTCAACAAAGGGT	0.552													10	59					0.00010058	0.00010717	1	0	A	45395690	A	A	45395690	2	1	273	1	0	0	0	0	0	0	0	1	16424	813	29	2		2	TOMM40	19	45395690	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	5438561	45395690	13733293	230	49653											
RELB	5971	broad.mit.edu	37	chr19	45540982	45540982	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttgtgggcagcaacatgttCcccaatcattaccgcgaggc	9	9	10	13	2	1	0	1	0	0	0	2	1	2	0	3	2	3	3	3	2	3	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:45540982C>T	uc002paj.1	+	13	1800	c.1674C>T	c.(1672-1674)TTC>TTT	p.F558F	SFRS16_uc002pak.2_5'Flank|SFRS16_uc002pal.2_5'Flank|SFRS16_uc010xxh.1_5'Flank|SFRS16_uc002pam.2_5'Flank|SFRS16_uc002pan.1_5'Flank	NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	558						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		GCAACATGTTCCCCAATCATT	0.697													5	33					0	0	0	0	T	45540982	T	T	45540982	2	4	273	1	0	0	0	0	0	0	0	1	13282	854	30	2		2	RELB	19	45540982	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	145292	45540982	13588001	231	49654											
FGF21	26291	broad.mit.edu	37	chr19	49260229	49260229	+	Frame_Shift_Del	DEL	G	-	-																															ccgggagttattcaaatcttGggagtcaagacatccaggtt																										TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:49260229delG	uc002pkn.1	+	3	854	c.282delG	c.(280-282)TTGfs	p.L94fs	FUT1_uc002pkk.2_5'Flank|FUT1_uc002pkm.1_5'Flank|FGF21_uc002pko.1_Frame_Shift_Del_p.L94fs	NM_019113	NP_061986	Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21 precursor	94					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TTCAAATCTTGGGAGTCAAGA	0.577													---	---	---								-	49260229	-	-	49260229	7	5	273	1	0	1	0	1	0	0	0	0	5882	1339	47	0	288	0	FGF21	19	49260229	Frame_Shift_Del	DEL	G	TCGA-CX-7086-01A-11D-2078-08	3719247	49260229	9868754	232	49655											
CPT1C	126129	broad.mit.edu	37	chr19	50212082	50212082	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agccccagcggctgcaatggGaccttccagaccaggtgagg	9	5	14	13	1	0	2	0	1	0	1	1	3	1	3	5	4	3	2	5	4	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:50212082G>C	uc002ppj.2	+	13	1757	c.1552G>C	c.(1552-1554)GAC>CAC	p.D518H	CPT1C_uc002ppl.3_Missense_Mutation_p.D484H|CPT1C_uc002ppi.2_Missense_Mutation_p.D435H|CPT1C_uc002ppk.2_Missense_Mutation_p.D507H|CPT1C_uc010eng.2_Missense_Mutation_p.D518H|CPT1C_uc010enh.2_Missense_Mutation_p.D518H|CPT1C_uc010ybc.1_Missense_Mutation_p.D389H|CPT1C_uc010eni.1_Missense_Mutation_p.D175H	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	518	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GCTGCAATGGGACCTTCCAGA	0.478													15	39					0	0	0	0	C	50212082	C	C	50212082	3	2	273	1	0	0	0	0	1	0	0	0	3848	1174	41	2	1598	2	CPT1C	19	50212082	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	951853	50212082	8916901	233	49656											
ZNF701	55762	broad.mit.edu	37	chr19	53086538	53086538	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cattcatactggagagaaacGttacaagtgtaatgaatgtg	15	11	10	5	1	1	2	1	1	0	1	1	4	1	3	0	1	3	2	0	1	6	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:53086538G>C	uc002pzs.1	+	4	1353	c.1226G>C	c.(1225-1227)CGT>CCT	p.R409P	ZNF701_uc010ydn.1_Missense_Mutation_p.R475P	NM_018260	NP_060730	Q9NV72	ZN701_HUMAN	zinc finger protein 701	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		GGAGAGAAACGTTACAAGTGT	0.373													5	41					0	0	0	0	C	53086538	C	C	53086538	3	2	273	1	0	0	0	0	1	0	0	0	18172	1145	40	3	1438	3	ZNF701	19	53086538	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	2874456	53086538	6042445	234	49657											
ZNF83	55769	broad.mit.edu	37	chr19	53116465	53116465	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaaggtttctctccagtGtgaattttccgatgatgtgc	8	16	10	7	1	1	3	0	3	1	0	4	4	3	3	2	1	1	1	2	1	2	4			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:53116465G>T	uc002pzu.3	-	2	2597	c.1353C>A	c.(1351-1353)CAC>CAA	p.H451Q	ZNF83_uc002pzv.3_Missense_Mutation_p.H451Q|ZNF83_uc010eps.2_Missense_Mutation_p.H423Q|ZNF83_uc010ept.2_Missense_Mutation_p.H451Q|ZNF83_uc010epu.2_Missense_Mutation_p.H451Q|ZNF83_uc010epv.2_Missense_Mutation_p.H451Q|ZNF83_uc010epw.2_Missense_Mutation_p.H451Q|ZNF83_uc010epx.2_Missense_Mutation_p.H423Q|ZNF83_uc010epy.2_Missense_Mutation_p.H451Q|ZNF83_uc010epz.2_Missense_Mutation_p.H423Q	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	451	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		TCTCTCCAGTGTGAATTTTCC	0.388													19	64					7.45023e-12	8.62217e-12	1	0	T	53116465	T	T	53116465	3	4	273	1	0	0	0	0	1	0	0	0	18250	1368	48	4	201	4	ZNF83	19	53116465	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	29927	53116465	6012518	235	49658											
PRKCG	5582	broad.mit.edu	37	chr19	54392993	54392993	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggcttgtgcaccagggcatGaaatgctcctgtgagtgacc	8	9	14	10	0	0	3	0	3	0	0	1	3	1	3	3	2	2	4	3	2	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:54392993G>C	uc002qcq.1	+	4	669	c.387G>C	c.(385-387)ATG>ATC	p.M129I	PRKCG_uc010eqz.1_Missense_Mutation_p.M129I|PRKCG_uc010yef.1_Missense_Mutation_p.M129I|PRKCG_uc010yeg.1_Missense_Mutation_p.M129I|PRKCG_uc010yeh.1_Intron	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	129	Phorbol-ester/DAG-type 2.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACCAGGGCATGAAATGCTCCT	0.632													4	23					0	0	0	0	C	54392993	C	C	54392993	3	2	273	1	0	0	0	0	1	0	0	0	12574	1290	45	2	401	2	PRKCG	19	54392993	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1276528	54392993	4735990	236	49659											
FCAR	2204	broad.mit.edu	37	chr19	55401062	55401062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacttgatccgcatggccGtggcaggactggtcctcgtg	7	9	14	11	3	0	2	0	1	0	1	3	3	2	3	3	4	1	2	3	4	1	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:55401062G>A	uc002qhr.1	+	5	894	c.697G>A	c.(697-699)GTG>ATG	p.V233M	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Missense_Mutation_p.V184M|FCAR_uc010esi.1_Missense_Mutation_p.V110M|FCAR_uc002qhu.1_Missense_Mutation_p.V137M|FCAR_uc002qhv.1_Missense_Mutation_p.V211M|FCAR_uc002qhw.1_Missense_Mutation_p.V221M|FCAR_uc002qhx.1_Missense_Mutation_p.V125M|FCAR_uc002qhy.1_Missense_Mutation_p.V199M|FCAR_uc002qhz.1_Missense_Mutation_p.R196H|FCAR_uc002qia.1_Missense_Mutation_p.V124M	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	233	Helical; (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		CCGCATGGCCGTGGCAGGACT	0.527													47	186					0	0	0	0	A	55401062	A	A	55401062	3	1	273	1	0	0	0	0	1	0	0	0	5805	1145	40	1	786	1	FCAR	19	55401062	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	1008069	55401062	3727921	237	49660											
NLRP7	199713	broad.mit.edu	37	chr19	55447788	55447788	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtacgcggtgtcaggggtgAcgtttttaatcctagggaaa	9	11	15	6	3	1	1	1	1	0	0	2	2	2	2	1	5	1	2	1	5	4	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:55447788A>G	uc002qih.3	-	6	2217	c.2141T>C	c.(2140-2142)GTC>GCC	p.V714A	NLRP7_uc002qig.3_Missense_Mutation_p.V686A|NLRP7_uc002qii.3_Missense_Mutation_p.V714A|NLRP7_uc010esk.2_Missense_Mutation_p.V714A|NLRP7_uc010esl.2_Missense_Mutation_p.V742A	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	714							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GTCAGGGGTGACGTTTTTAAT	0.483													6	14					0	0	0	0	G	55447788	G	G	55447788	3	3	273	1	0	0	0	0	1	0	0	0	10536	275	10	5	996	5	NLRP7	19	55447788	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	46726	55447788	3681195	238	49661											
ZNF324B	388569	broad.mit.edu	37	chr19	58967773	58967773	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtgtgcacgcagtgtggcCgcgccttccgtgagcgccct	3	9	14	15	6	0	1	0	1	0	0	2	1	1	1	4	1	2	2	4	1	0	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr19:58967773C>T	uc002qsv.1	+	4	1569	c.1462C>T	c.(1462-1464)CGC>TGC	p.R488C	ZNF324B_uc002qsu.1_Missense_Mutation_p.R478C|ZNF324B_uc010euq.1_Missense_Mutation_p.R488C	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	488	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCAGTGTGGCCGCGCCTTCCG	0.662													7	43					0	0	0	0	T	58967773	T	T	58967773	3	4	273	1	0	0	0	0	1	0	0	0	17912	652	23	1	1472	1	ZNF324B	19	58967773	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	3519985	58967773	161210	239	49662											
PLCB1	23236	broad.mit.edu	37	chr20	8639216	8639216	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaccatatcttaccgttGatcagatgatggattttatc	12	14	7	8	1	2	3	1	2	1	1	3	4	2	4	2	1	2	2	2	1	4	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr20:8639216G>T	uc002wnb.2	+	9	730	c.727G>T	c.(727-729)GAT>TAT	p.D243Y	PLCB1_uc010zrb.1_Missense_Mutation_p.D142Y|PLCB1_uc002wna.2_Missense_Mutation_p.D243Y|PLCB1_uc002wnc.1_Missense_Mutation_p.D142Y	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	243					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TCTTACCGTTGATCAGATGAT	0.318													13	52					1.49906e-05	1.60837e-05	1	0	T	8639216	T	T	8639216	3	4	273	1	0	0	0	0	1	0	0	0	12082	1290	45	2	761	2	PLCB1	20	8639216	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08		8639216	54386304	240	49663											
SEL1L2	80343	broad.mit.edu	37	chr20	13839917	13839917	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaaattacctttgtgatGcctaagccgtgttcatacat	12	13	7	9	1	1	1	1	1	0	0	1	1	1	1	3	0	5	2	3	0	5	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr20:13839917G>A	uc010gcf.2	-	18	1891	c.1809C>T	c.(1807-1809)GGC>GGT	p.G603G	SEL1L2_uc002woq.3_Silent_p.G464G|SEL1L2_uc010zrl.1_Intron|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	603	Extracellular (Potential).|Sel1-like 11.					integral to membrane	binding			ovary(2)	2						CCTTTGTGATGCCTAAGCCGT	0.393													11	12					0	0	0	0	A	13839917	A	A	13839917	2	1	273	1	0	0	0	0	0	0	0	1	14076	1306	46	4		4	SEL1L2	20	13839917	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	5200701	13839917	49185603	241	49664											
FAM83C	128876	broad.mit.edu	37	chr20	33876280	33876280	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcacctgtaactgcccgccaCcacttgctcacagtcaatga	10	9	6	16	1	3	1	3	1	0	0	3	1	3	1	4	0	3	2	4	0	2	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr20:33876280C>A	uc010zux.1	-	3	908	c.790G>T	c.(790-792)GTG>TTG	p.V264L	FAM83C_uc002xcb.1_Intron	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	264										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CTGCCCGCCACCACTTGCTCA	0.602													6	56					0.000157383	0.000165413	1	0	A	33876280	A	A	33876280	3	1	273	1	0	0	0	0	1	0	0	0	5667	507	18	4	1461	4	FAM83C	20	33876280	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	20036363	33876280	29149240	242	49665											
ACTR5	79913	broad.mit.edu	37	chr20	37396229	37396229	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagatgagacccttccggtCttcttttcaggtactgattg	7	14	11	9	1	3	3	1	2	2	2	4	5	4	3	2	3	1	1	2	3	1	6			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr20:37396229C>T	uc002xjd.2	+	8	1581	c.1556C>T	c.(1555-1557)TCT>TTT	p.S519F		NM_024855	NP_079131	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog	519					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding				0		Myeloproliferative disorder(115;0.00878)				CCCTTCCGGTCTTCTTTTCAG	0.373													7	55					0	0	0	0	T	37396229	T	T	37396229	3	4	273	1	0	0	0	0	1	0	0	0	215	913	32	2	1586	2	ACTR5	20	37396229	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	3519949	37396229	25629291	243	49666											
SNX21	90203	broad.mit.edu	37	chr20	44469390	44469390	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacctgcagcggcaattccGgggcccaatggctgccatct	9	7	11	14	2	1	0	0	0	1	0	2	0	2	0	4	4	4	3	4	4	3	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr20:44469390G>A	uc002xpv.1	+	4	649	c.560G>A	c.(559-561)CGG>CAG	p.R187Q	SNX21_uc002xps.1_Missense_Mutation_p.R187Q|SNX21_uc002xpt.1_3'UTR|SNX21_uc002xpu.1_3'UTR|SNX21_uc002xpw.1_5'UTR|SNX21_uc002xpx.2_Missense_Mutation_p.R177Q|SNX21_uc010zxd.1_3'UTR|SNX21_uc002xpy.1_5'UTR|SNX21_uc002xpz.1_5'UTR	NM_033421	NP_219489	Q969T3	SNX21_HUMAN	sorting nexin 21 isoform a	187	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			breast(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				CGGCAATTCCGGGGCCCAATG	0.627													31	65					0	0	0	0	A	44469390	A	A	44469390	3	1	273	1	0	0	0	0	1	0	0	0	14957	1116	39	1	589	1	SNX21	20	44469390	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	7073161	44469390	18556130	244	49667											
NCOA5	57727	broad.mit.edu	37	chr20	44692044	44692044	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catcagccgctccttccgctCtcgcaggtagttgatgatct	6	12	9	14	3	3	2	1	2	2	0	6	2	5	2	3	1	1	5	3	1	1	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr20:44692044C>T	uc002xrd.2	-	6	1633	c.1105G>A	c.(1105-1107)GAG>AAG	p.E369K	NCOA5_uc002xrc.2_Missense_Mutation_p.E257K|NCOA5_uc002xre.2_Missense_Mutation_p.E369K	NM_020967	NP_066018	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				TCCTTCCGCTCTCGCAGGTAG	0.577													5	40					0	0	0	0	T	44692044	T	T	44692044	3	4	273	1	0	0	0	0	1	0	0	0	10286	922	32	2	642	2	NCOA5	20	44692044	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	222654	44692044	18333476	245	49668											
DPM1	8813	broad.mit.edu	37	chr20	49562395	49562395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accacttacatggtgtgagaGatcagcatccataataatga	15	10	8	8	0	1	3	1	2	0	1	2	4	2	3	2	1	2	1	2	1	3	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr20:49562395G>A	uc002xvw.1	-	4	361	c.361C>T	c.(361-363)CTC>TTC	p.L121F	DPM1_uc002xvv.1_Missense_Mutation_p.L16F|DPM1_uc002xvx.1_RNA	NM_003859	NP_003850	O60762	DPM1_HUMAN	dolichyl-phosphate mannosyltransferase 1	121					C-terminal protein lipidation|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|protein N-linked glycosylation via asparagine|protein O-linked mannosylation	dolichol-phosphate-mannose synthase complex|endoplasmic reticulum membrane|membrane fraction	dolichyl-phosphate beta-D-mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding			ovary(1)	1						TGGTGTGAGAGATCAGCATCC	0.323													32	43					0	0	0	0	A	49562395	A	A	49562395	3	1	273	1	0	0	0	0	1	0	0	0	4746	942	33	2	445	2	DPM1	20	49562395	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	4870351	49562395	13463125	246	49669											
BRWD1	54014	broad.mit.edu	37	chr21	40572223	40572223	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccactgcgtgaggaggattCacgagctctggaactctctt	8	10	11	12	2	3	1	1	1	2	0	4	5	3	4	1	3	3	1	1	3	1	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr21:40572223C>T	uc002yxk.1	-	39	4814	c.4675G>A	c.(4675-4677)GAA>AAA	p.E1559K	BRWD1_uc010goc.1_Missense_Mutation_p.E202K|BRWD1_uc002yxl.2_Missense_Mutation_p.E1559K	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GAGGAGGATTCACGAGCTCTG	0.443													15	28					0	0	0	0	T	40572223	T	T	40572223	3	4	273	1	0	0	0	0	1	0	0	0	1530	835	29	2	2542	2	BRWD1	21	40572223	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08		40572223	7557672	247	49670											
TSSK2	23617	broad.mit.edu	37	chr22	19118919	19118919	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgctcctggcaccatggacGatgccacagtcctaaggaag	10	7	11	13	2	0	0	0	0	0	0	3	3	2	2	4	3	1	2	4	3	2	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr22:19118919G>A	uc002zow.2	+	1	599	c.7G>A	c.(7-9)GAT>AAT	p.D3N	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	3					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					CACCATGGACGATGCCACAGT	0.562													6	13					0	0	0	0	A	19118919	A	A	19118919	3	1	273	1	0	0	0	0	1	0	0	0	16736	1058	37	1	9	1	TSSK2	22	19118919	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08		19118919	32185647	248	49671											
PES1	23481	broad.mit.edu	37	chr22	30983347	30983347	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctacagtgttccactcgctCttcccataagccttccggag	7	12	7	15	2	2	0	0	0	2	0	6	1	5	1	4	1	2	2	4	1	2	5			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr22:30983347C>G	uc003aij.1	-	4	368	c.294G>C	c.(292-294)AAG>AAC	p.K98N	PES1_uc003aik.1_Missense_Mutation_p.K98N|PES1_uc003ail.1_Missense_Mutation_p.K98N|PES1_uc003aim.1_Missense_Mutation_p.K98N|PES1_uc003ain.1_5'UTR|PES1_uc003aio.1_5'UTR	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	98	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						TCCACTCGCTCTTCCCATAAG	0.507													13	55					0	0	0	0	G	30983347	G	G	30983347	3	3	273	1	0	0	0	0	1	0	0	0	11787	912	32	2	1520	2	PES1	22	30983347	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	11864428	30983347	20321219	249	49672											
NPTXR	23467	broad.mit.edu	37	chr22	39218697	39218697	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caccaacttgtcttcccaggGaaggacgttgcccagcagtg	9	8	11	13	1	1	0	0	0	1	0	2	2	2	2	3	2	3	2	3	2	2	3			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr22:39218697G>A	uc003awk.2	-	5	1574	c.1420C>T	c.(1420-1422)CCC>TCC	p.P474S		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	474	Pentaxin.|Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					TCTTCCCAGGGAAGGACGTTG	0.617													6	17					0	0	0	0	A	39218697	A	A	39218697	3	1	273	1	0	0	0	0	1	0	0	0	10658	1174	41	2	86	2	NPTXR	22	39218697	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	8235350	39218697	12085869	250	49673											
MCHR1	2847	broad.mit.edu	37	chr22	41077104	41077104	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactggtgcaacaacgtcccCgacatcttcatcatcaacct	11	9	5	16	2	4	0	3	0	1	0	5	1	5	0	3	1	4	1	3	1	3	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr22:41077104C>A	uc003ayz.2	+	2	709	c.441C>A	c.(439-441)CCC>CCA	p.P147P	MCHR1_uc003aza.2_Silent_p.P36P	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	147	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0						ACAACGTCCCCGACATCTTCA	0.562													14	54					0.000151284	0.000160642	1	0	A	41077104	A	A	41077104	2	1	273	1	0	0	0	0	0	0	0	1	9435	639	23	3		3	MCHR1	22	41077104	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	1858407	41077104	10227462	251	49674											
ATXN10	25814	broad.mit.edu	37	chr22	46088947	46088947	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgcgagtggaacaggaatCtctgttgacaggtagcatgc	11	9	13	8	1	1	1	0	1	1	0	2	4	1	3	0	3	4	3	0	3	3	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr22:46088947C>G	uc003bgm.1	+	3	637	c.380C>G	c.(379-381)TCT>TGT	p.S127C	ATXN10_uc011aqt.1_Missense_Mutation_p.S63C|ATXN10_uc003bgn.1_Translation_Start_Site	NM_013236	NP_037368	Q9UBB4	ATX10_HUMAN	ataxin 10	127					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm		p.S127C(1)		ovary(1)|kidney(1)	2		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		GAACAGGAATCTCTGTTGACA	0.328													8	27					0	0	0	0	G	46088947	G	G	46088947	3	3	273	1	0	0	0	0	1	0	0	0	1212	913	32	2	390	2	ATXN10	22	46088947	Missense_Mutation	SNP	C	TCGA-CX-7086-01A-11D-2078-08	5011843	46088947	5215619	252	49675											
MLC1	23209	broad.mit.edu	37	chr22	50500013	50500013	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggtttccgcgtctgggggtCactgggccatttgcaccacg	4	10	14	13	4	2	0	1	0	1	0	3	0	3	0	3	4	1	2	3	4	0	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chr22:50500013C>T	uc003bjg.1	-	12	1406	c.1133G>A	c.(1132-1134)TGA>TAA	p.*378*	MLC1_uc011arl.1_Silent_p.*326*|MLC1_uc003bjh.1_Silent_p.*378*|MLC1_uc011arm.1_Silent_p.*348*|MLC1_uc011arn.1_Silent_p.*299*|MLC1_uc011aro.1_Silent_p.*344*	NM_139202	NP_631941	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with	378						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		GTCTGGGGGTCACTGGGCCAT	0.607													10	37					0	0	0	0	T	50500013	T	T	50500013	2	4	273	1	0	0	0	0	0	0	0	1	9665	837	29	2		2	MLC1	22	50500013	Silent	SNP	C	TCGA-CX-7086-01A-11D-2078-08	4411066	50500013	804553	253	49676											
DDX53	168400	broad.mit.edu	37	chrX	23018798	23018798	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacataacgtgtgatgacttGaaaagtggtgaaaagcgtct	15	10	11	5	2	1	4	0	4	1	0	1	4	1	4	0	1	3	0	0	1	6	2			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chrX:23018798G>C	uc004daj.2	+	1	712	c.624G>C	c.(622-624)TTG>TTC	p.L208F		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	208						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						GTGATGACTTGAAAAGTGGTG	0.378													15	14					0	0	0	0	C	23018798	C	C	23018798	3	2	273	1	0	0	0	0	1	0	0	0	4388	1281	45	2	626	2	DDX53	23	23018798	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08		23018798	132251762	254	49677											
CYLC1	1538	broad.mit.edu	37	chrX	83128670	83128670	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagttaagaaaaatgtcaaGaaagatgacaagaaaaagga	25	5	9	2	0	1	5	1	1	0	4	1	6	1	6	0	1	0	1	0	1	9	1			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chrX:83128670G>A	uc004eei.1	+	4	975	c.954G>A	c.(952-954)AAG>AAA	p.K318K	CYLC1_uc004eeh.1_Silent_p.K317K	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	318	2.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						AAAATGTCAAGAAAGATGACA	0.299													22	6					0	0	0	0	A	83128670	A	A	83128670	2	1	273	1	0	0	0	0	0	0	0	1	4158	933	33	2		2	CYLC1	23	83128670	Silent	SNP	G	TCGA-CX-7086-01A-11D-2078-08	60109872	83128670	72141890	255	49678											
TBC1D8B	54885	broad.mit.edu	37	chrX	106097447	106097447	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaatatggtaatattcgctAtgaagatatacatagtatgc	16	13	8	4	1	0	2	0	1	0	1	1	3	0	2	0	1	2	3	0	1	10	9			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chrX:106097447A>G	uc004emo.2	+	14	2438	c.2273A>G	c.(2272-2274)TAT>TGT	p.Y758C	MORC4_uc004emp.3_Intron	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	758						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AATATTCGCTATGAAGATATA	0.353													25	6					0	0	0	0	G	106097447	G	G	106097447	3	3	273	1	0	0	0	0	1	0	0	0	15692	449	16	5	2393	5	TBC1D8B	23	106097447	Missense_Mutation	SNP	A	TCGA-CX-7086-01A-11D-2078-08	22968777	106097447	49173113	256	49679											
ACSL4	2182	broad.mit.edu	37	chrX	108912328	108912328	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtaatcataccctatcttGaacagagttttctgaatata	13	16	5	7	0	3	3	1	2	2	1	3	3	3	3	1	0	2	2	1	0	7	9			TCGA-CX-7086-01A-11D-2078-08	TCGA-CX-7086-10D-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	dfcb7c6e-b0f4-4557-9669-4c580d1093a0	46e82d02-3ae8-46f0-9615-e8b9ca710f23	g.chrX:108912328G>C	uc004eoi.2	-	11	1705	c.1200C>G	c.(1198-1200)TTC>TTG	p.F400L	ACSL4_uc004eoj.2_Missense_Mutation_p.F359L|ACSL4_uc004eok.2_Missense_Mutation_p.F359L|ACSL4_uc010npp.1_Missense_Mutation_p.F400L	NM_022977	NP_075266	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	400	Cytoplasmic (Potential).				fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(1)|lung(1)|ovary(1)	3					Icosapent(DB00159)|Troglitazone(DB00197)	ACCCTATCTTGAACAGAGTTT	0.323													14	33					0	0	0	0	C	108912328	C	C	108912328	3	2	273	1	0	0	0	0	1	0	0	0	179	1281	45	2	963	2	ACSL4	23	108912328	Missense_Mutation	SNP	G	TCGA-CX-7086-01A-11D-2078-08	2814881	108912328	46358232	257	49680											
KLHL17	339451	broad.mit.edu	37	chr1	896822	896822	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggccatgagccgcatgcGccagcgcggcctcctgtgcg	4	6	15	16	6	0	1	0	1	0	0	1	1	1	1	5	2	4	1	5	2	0	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:896822G>A	uc001aca.1	+	2	364	c.257G>A	c.(256-258)CGC>CAC	p.R86H	NOC2L_uc001aby.3_5'Flank|NOC2L_uc001abz.3_5'Flank|NOC2L_uc009vjq.2_5'Flank|NOC2L_uc009vjr.1_5'Flank|KLHL17_uc001acb.1_5'Flank|KLHL17_uc010nya.1_5'Flank|KLHL17_uc001acc.1_5'Flank|KLHL17_uc010nyb.1_5'Flank	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	86					actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGCCGCATGCGCCAGCGCGGC	0.672													5	28					0	0	0	0	A	896822	A	A	896822	3	1	274	1	0	0	0	0	1	0	0	0	8411	1087	38	1	263	1	KLHL17	1	896822	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08		896822	248353799	1	49681											
SDF4	51150	broad.mit.edu	37	chr1	1152946	1152946	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagcttgctgcccgtgaaGaactcgctgtacttgagcac	9	9	10	13	2	0	3	0	2	0	1	1	3	0	3	2	0	6	5	2	0	3	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:1152946G>A	uc001adh.3	-	7	1364	c.1035C>T	c.(1033-1035)TTC>TTT	p.F345F	SDF4_uc001adg.2_RNA|SDF4_uc001adi.3_3'UTR|SDF4_uc009vjv.2_Silent_p.F223F|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	345	Necessary for intracellular retention in Golgi apparatus lumen (By similarity).|EF-hand 6.				cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		TGCCCGTGAAGAACTCGCTGT	0.537													11	57					0	0	0	0	A	1152946	A	A	1152946	2	1	274	1	0	0	0	0	0	0	0	1	14027	933	33	2		2	SDF4	1	1152946	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	256124	1152946	248097675	2	49682											
ACAP3	116983	broad.mit.edu	37	chr1	1235353	1235353	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccctcccaaaggctcacCtcggctgccagcttcttcat	7	9	6	19	1	3	0	2	0	1	0	5	0	4	0	5	2	2	3	5	2	1	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:1235353C>G	uc001aeb.2	-	8	737	c.663G>C	c.(661-663)GAG>GAC	p.E221D	ACAP3_uc001ady.2_5'Flank|ACAP3_uc001aea.2_Missense_Mutation_p.E179D|ACAP3_uc001aec.1_Missense_Mutation_p.E179D	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	221					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						AAAGGCTCACCTCGGCTGCCA	0.632													7	22					0	0	0	0	G	1235353	G	G	1235353	3	3	274	1	0	0	0	0	1	0	0	0	120	695	24	4	1909	4	ACAP3	1	1235353	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	82407	1235353	248015268	3	49683											
UBE4B	10277	broad.mit.edu	37	chr1	10211518	10211518	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaagtcatgtttatgaccaAccctgctgttcagccacgaa	12	10	8	11	1	2	2	2	1	0	1	2	3	2	2	3	0	3	3	3	0	4	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:10211518A>T	uc001aqs.3	+	21	3538	c.2825A>T	c.(2824-2826)AAC>ATC	p.N942I	UBE4B_uc001aqr.3_Missense_Mutation_p.N813I|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Missense_Mutation_p.N397I|UBE4B_uc001aqt.1_Missense_Mutation_p.N282I	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	942					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TTTATGACCAACCCTGCTGTT	0.428													15	100					0	0	0	0	T	10211518	T	T	10211518	3	4	274	1	0	0	0	0	1	0	0	0	16951	43	2	5	2907	5	UBE4B	1	10211518	Missense_Mutation	SNP	A	TCGA-CX-7219-01A-11D-2012-08	8976165	10211518	239039103	4	49684											
PGD	5226	broad.mit.edu	37	chr1	10473290	10473290	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctccgccctggaatacggcGtacccgtcaccctcattggt	6	10	9	16	4	3	0	2	0	1	0	4	1	3	1	4	3	2	1	4	3	3	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:10473290G>A	uc001arc.2	+	8	916	c.826G>A	c.(826-828)GTA>ATA	p.V276I	PGD_uc001ard.2_Missense_Mutation_p.V196I|PGD_uc010oak.1_Missense_Mutation_p.V254I|PGD_uc010oal.1_Missense_Mutation_p.V263I	NM_002631	NP_002622	P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	276					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		GGAATACGGCGTACCCGTCAC	0.542													17	33					0	0	0	0	A	10473290	A	A	10473290	3	1	274	1	0	0	0	0	1	0	0	0	11842	1145	40	1	856	1	PGD	1	10473290	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	261772	10473290	238777331	5	49685											
NBPF1	55672	broad.mit.edu	37	chr1	16902828	16902828	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agccagctgttcttggaggtCctgcccctgggacttgtctg	4	12	13	12	0	2	0	0	0	2	0	3	2	3	2	4	3	3	2	4	3	0	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:16902828C>T	uc009vos.1	-	19	2941	c.2053G>A	c.(2053-2055)GAC>AAC	p.D685N	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Missense_Mutation_p.D143N|NBPF1_uc010oce.1_Missense_Mutation_p.D414N	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	685						cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTGGAGGTCCTGCCCCTGG	0.577													25	748					0	0	0	0	T	16902828	T	T	16902828	3	4	274	1	0	0	0	0	1	0	0	0	10245	855	30	2	1415	2	NBPF1	1	16902828	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	6429538	16902828	232347793	6	49686											
CAP1	10487	broad.mit.edu	37	chr1	40525772	40525772	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atatgtgcaggcatttgactCgctgcttgctggtcctgtgg	5	14	13	9	1	0	1	0	1	0	0	2	1	1	1	1	3	3	5	1	3	1	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:40525772C>T	uc001cfa.3	+	3	375	c.146C>T	c.(145-147)TCG>TTG	p.S49L	CAP1_uc010ojd.1_RNA|CAP1_uc001cey.3_Missense_Mutation_p.S49L|CAP1_uc001cez.3_Missense_Mutation_p.S49L|CAP1_uc009vvz.2_Missense_Mutation_p.S49L|CAP1_uc010oje.1_Missense_Mutation_p.R19C	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	49					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCATTTGACTCGCTGCTTGCT	0.463													21	49					0	0	0	0	T	40525772	T	T	40525772	3	4	274	1	0	0	0	0	1	0	0	0	2631	893	31	1	152	1	CAP1	1	40525772	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	23622944	40525772	208724849	7	49687											
KIAA0467	23334	broad.mit.edu	37	chr1	43909378	43909378	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagccttggctgaaggagctGagcttggctttcctgcagca	7	10	14	10	0	0	2	0	2	0	0	1	4	1	3	2	3	5	6	2	3	1	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:43909378G>A	uc001cjk.1	+	47	6501	c.6039G>A	c.(6037-6039)CTG>CTA	p.L2013L	KIAA0467_uc001cjl.1_5'Flank	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2912						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGAAGGAGCTGAGCTTGGCTT	0.632													45	153					0	0	0	0	A	43909378	A	A	43909378	2	1	274	1	0	0	0	0	0	0	0	1	8217	1277	45	2		2	KIAA0467	1	43909378	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	3383606	43909378	205341243	8	49688											
NBPF9	400818	broad.mit.edu	37	chr1	144618116	144618116	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttcactctcaggaacgaGagctgacgcagttaaaggag	12	8	13	8	2	2	2	2	1	1	1	3	5	2	4	0	3	2	4	0	3	3	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:144618116G>T	uc009wig.1	+	6	389	c.313G>T	c.(313-315)GAG>TAG	p.E105*	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Nonsense_Mutation_p.E36*|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Nonsense_Mutation_p.E36*|NBPF9_uc010oyg.1_Nonsense_Mutation_p.E70*|NBPF9_uc009wii.1_5'UTR	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	105	Potential.					cytoplasm					0						TCAGGAACGAGAGCTGACGCA	0.473													59	472					8.3131e-28	2.40283e-27	1	0	T	144618116	T	T	144618116	4	4	274	1	0	0	0	0	0	1	0	0	10253	943	33	2	321	2	NBPF9	1	144618116	Nonsense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	100708738	144618116	104632505	9	49689											
PRG4	10216	broad.mit.edu	37	chr1	186275989	186275989	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgcacccaccacccccaagGagcctgcacccaccaccacc	10	2	5	24	0	0	0	0	0	0	0	0	1	0	1	9	1	3	2	9	1	1	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:186275989G>T	uc001gru.3	+	7	1189	c.1138G>T	c.(1138-1140)GAG>TAG	p.E380*	PRG4_uc001grt.3_Nonsense_Mutation_p.E339*|PRG4_uc009wyl.2_Nonsense_Mutation_p.E287*|PRG4_uc009wym.2_Nonsense_Mutation_p.E246*|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	380	5.|59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CACCCCCAAGGAGCCTGCACC	0.642													22	101					1.10513e-12	3.04815e-12	1	0	T	186275989	T	T	186275989	4	4	274	1	0	0	0	0	0	1	0	0	12543	1175	41	2	1160	2	PRG4	1	186275989	Nonsense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	41657873	186275989	62974632	10	49690											
PTPRC	5788	broad.mit.edu	37	chr1	198719738	198719738	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttattgttatgctgacagaaCtgaaacatggagaccaggtt	13	12	10	6	0	0	4	0	2	0	2	0	5	0	4	1	2	3	3	1	2	4	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:198719738C>T	uc001gur.1	+	29	3364	c.3184C>T	c.(3184-3186)CTG>TTG	p.L1062L	PTPRC_uc001gus.1_Silent_p.L1014L|PTPRC_uc001gut.1_Silent_p.L901L	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1062	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GCTGACAGAACTGAAACATGG	0.408													16	78					0	0	0	0	T	198719738	T	T	198719738	2	4	274	1	0	0	0	0	0	0	0	1	12862	564	20	4		4	PTPRC	1	198719738	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	12443749	198719738	50530883	11	49691											
DDX59	83479	broad.mit.edu	37	chr1	200635479	200635479	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagatgtttcgctttacaCtccaaactacacacatcttc	13	12	4	12	1	1	2	0	0	1	2	4	2	2	2	1	0	3	2	1	0	4	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:200635479C>A	uc009wzk.2	-	2	633	c.390G>T	c.(388-390)GAG>GAT	p.E130D	DDX59_uc010ppl.1_Missense_Mutation_p.E130D	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	130	HIT-type.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TCGCTTTACACTCCAAACTAC	0.448													20	58					2.37509e-13	6.594e-13	1	0	A	200635479	A	A	200635479	3	1	274	1	0	0	0	0	1	0	0	0	4393	564	20	4	1497	4	DDX59	1	200635479	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	1915741	200635479	48615142	12	49692											
KIF26B	55083	broad.mit.edu	37	chr1	245775205	245775205	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggactgtgatgaggacgaCcaccgcaactcacacgtgtt	11	7	11	12	3	1	2	1	2	0	0	1	5	1	4	2	2	1	2	2	2	1	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr1:245775205C>T	uc001ibf.1	+	9	2465	c.2025C>T	c.(2023-2025)GAC>GAT	p.D675D	KIF26B_uc010pyq.1_Silent_p.D675D|KIF26B_uc001ibg.1_Silent_p.D293D	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	675	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			ATGAGGACGACCACCGCAACT	0.612													6	45					0	0	0	0	T	245775205	T	T	245775205	2	4	274	1	0	0	0	0	0	0	0	1	8334	506	18	4		4	KIF26B	1	245775205	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	45139726	245775205	3475416	13	49693											
SLC5A7	60482	broad.mit.edu	37	chr2	108622649	108622649	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tactcattggggccattggaGcatcaacaggtaaatctctt	11	12	9	9	0	3	0	2	0	1	0	4	1	3	1	1	4	3	2	1	4	4	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:108622649G>A	uc002tdv.2	+	7	1162	c.886G>A	c.(886-888)GCA>ACA	p.A296T	SLC5A7_uc010ywm.1_Missense_Mutation_p.A49T|SLC5A7_uc010fjj.2_Missense_Mutation_p.A296T|SLC5A7_uc010ywn.1_Missense_Mutation_p.A183T	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	296	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GGCCATTGGAGCATCAACAGG	0.542													23	70					0	0	0	0	A	108622649	A	A	108622649	3	1	274	1	0	0	0	0	1	0	0	0	14734	971	34	4	908	4	SLC5A7	2	108622649	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08		108622649	134576724	14	49694											
TTN	7273	broad.mit.edu	37	chr2	179434249	179434249	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttaacttctggtgtaggaCgaccttttataggaacaaat	13	14	8	6	1	1	0	0	0	1	0	1	3	1	2	1	3	2	1	1	3	6	7			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:179434249C>T	uc010zfg.1	-	275	69130	c.68906G>A	c.(68905-68907)CGT>CAT	p.R22969H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16664H|TTN_uc010zfi.1_Missense_Mutation_p.R16597H|TTN_uc010zfj.1_Missense_Mutation_p.R16472H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23896							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTGTAGGACGACCTTTTAT	0.393													4	42					0	0	0	0	T	179434249	T	T	179434249	3	4	274	1	0	0	0	0	1	0	0	0	16803	536	19	1	31517	1	TTN	2	179434249	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	70811600	179434249	63765124	15	49695											
TTN	7273	broad.mit.edu	37	chr2	179648932	179648932	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtgtgtcagcgaaggggaaCtgtggcaagggtgtgggctc	7	8	20	6	1	1	0	1	0	0	0	2	2	1	1	0	6	2	2	0	6	3	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:179648932C>T	uc010zfg.1	-	16	2864	c.2640G>A	c.(2638-2640)CAG>CAA	p.Q880Q	TTN_uc010zfh.1_Silent_p.Q834Q|TTN_uc010zfi.1_Silent_p.Q834Q|TTN_uc010zfj.1_Silent_p.Q834Q|TTN_uc002unb.2_Silent_p.Q880Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	880							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGAAGGGGAACTGTGGCAAGG	0.537													17	65					0	0	0	0	T	179648932	T	T	179648932	2	4	274	1	0	0	0	0	0	0	0	1	16803	564	20	4		4	TTN	2	179648932	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	214683	179648932	63550441	16	49696											
PDE1A	5136	broad.mit.edu	37	chr2	183033014	183033014	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acttctgtgaactggttcttGcttctgaaaaaaaaaaaagc	15	12	7	7	0	3	2	0	2	3	0	3	2	3	2	0	1	3	2	0	1	7	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:183033014G>C	uc002uos.2	-	15	1652	c.1568C>G	c.(1567-1569)GCA>GGA	p.A523G	PDE1A_uc010zfp.1_Intron|PDE1A_uc002uoq.1_Intron|PDE1A_uc010zfq.1_Intron|PDE1A_uc002uor.2_Missense_Mutation_p.A507G|PDE1A_uc002uou.2_Missense_Mutation_p.A489G	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	523					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			ACTGGTTCTTGCTTCTGAAAA	0.318													10	35					0	0	0	0	C	183033014	C	C	183033014	3	2	274	1	0	0	0	0	1	0	0	0	11687	1319	46	4	121	4	PDE1A	2	183033014	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	3384082	183033014	60166359	17	49697											
HECW2	57520	broad.mit.edu	37	chr2	197189757	197189757	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatgatagtagaccgtctctCctgcccgtggtgggcacagg	7	9	14	11	2	1	2	0	1	1	1	3	3	2	2	3	3	1	2	3	3	2	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:197189757C>T	uc002utm.1	-	6	871	c.688G>A	c.(688-690)GAG>AAG	p.E230K	HECW2_uc002utl.1_5'UTR	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	230	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GACCGTCTCTCCTGCCCGTGG	0.498													62	184					0	0	0	0	T	197189757	T	T	197189757	3	4	274	1	0	0	0	0	1	0	0	0	7082	864	30	2	4126	2	HECW2	2	197189757	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	14156743	197189757	46009616	18	49698											
NDUFB3	4709	broad.mit.edu	37	chr2	201950235	201950235	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagagtgtttccttttctgAtgtattctttaaaggattca	11	18	7	5	0	3	2	1	1	2	1	4	3	4	3	1	1	0	2	1	1	4	8			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:201950235A>C	uc002uwx.3	+	3	517	c.194A>C	c.(193-195)GAT>GCT	p.D65A		NM_002491	NP_002482	O43676	NDUB3_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	65					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	TCCTTTTCTGATGTATTCTTT	0.363													3	68					0	0	0	0	C	201950235	C	C	201950235	3	2	274	1	0	0	0	0	1	0	0	0	10336	333	12	5	200	5	NDUFB3	2	201950235	Missense_Mutation	SNP	A	TCGA-CX-7219-01A-11D-2012-08	4760478	201950235	41249138	19	49699											
NBEAL1	65065	broad.mit.edu	37	chr2	204078305	204078305	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgtgtttgtgtcaccaaaGaatacagccatattcttgta	12	15	7	7	0	2	1	1	0	1	1	2	1	2	1	2	0	2	2	2	0	5	7			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:204078305G>C	uc002uzt.3	+	54	8245	c.7912G>C	c.(7912-7914)GAA>CAA	p.E2638Q	NBEAL1_uc002uzs.3_Missense_Mutation_p.E1279Q|NBEAL1_uc002uzu.2_Missense_Mutation_p.E133Q	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2638							binding			ovary(1)|skin(1)	2						TGTCACCAAAGAATACAGCCA	0.383													35	93					0	0	0	0	C	204078305	C	C	204078305	3	2	274	1	0	0	0	0	1	0	0	0	10241	943	33	2	8122	2	NBEAL1	2	204078305	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	2128070	204078305	39121068	20	49700											
SPHKAP	80309	broad.mit.edu	37	chr2	228884679	228884679	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggctgagggatctagactCtgcaaggctgtgttctttgt	6	15	13	7	0	3	2	0	1	3	1	3	3	3	3	0	3	1	4	0	3	2	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr2:228884679C>T	uc002vpq.2	-	7	938	c.891G>A	c.(889-891)CAG>CAA	p.Q297Q	SPHKAP_uc002vpp.2_Silent_p.Q297Q|SPHKAP_uc010zlx.1_Silent_p.Q297Q	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	297						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GATCTAGACTCTGCAAGGCTG	0.418													60	162					0	0	0	0	T	228884679	T	T	228884679	2	4	274	1	0	0	0	0	0	0	0	1	15114	912	32	2		2	SPHKAP	2	228884679	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	24806374	228884679	14314694	21	49701											
PLCL2	23228	broad.mit.edu	37	chr3	17084400	17084400	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaggcgttgattgaaaatgCagatgctgtatatgaaaaga	16	10	11	4	1	0	5	0	3	0	2	0	5	0	5	0	1	2	4	0	1	7	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:17084400C>T	uc011awc.1	+	7	3134	c.3029C>T	c.(3028-3030)GCA>GTA	p.A1010V	PLCL2_uc011awd.1_Missense_Mutation_p.A892V	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	1018					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						ATTGAAAATGCAGATGCTGTA	0.403													30	41					0	0	0	0	T	17084400	T	T	17084400	3	4	274	1	0	0	0	0	1	0	0	0	12095	710	25	4	3061	4	PLCL2	3	17084400	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08		17084400	180938030	22	49702											
SMARCC1	6599	broad.mit.edu	37	chr3	47703871	47703871	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacgcgagggtccaccacaGatgccaaaaaagcaacagta	16	3	9	13	2	0	1	0	0	0	1	1	2	1	1	4	1	3	2	4	1	5	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:47703871G>A	uc003crq.2	-	20	2229	c.2111C>T	c.(2110-2112)TCT>TTT	p.S704F	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.S595F	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	704					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		GTCCACCACAGATGCCAAAAA	0.493													9	21					0	0	0	0	A	47703871	A	A	47703871	3	1	274	1	0	0	0	0	1	0	0	0	14839	942	33	2	1242	2	SMARCC1	3	47703871	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	30619471	47703871	150318559	23	49703											
ERC2	26059	broad.mit.edu	37	chr3	56468821	56468821	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccctttgggtaggttgttGaagccaccccttcatgatca	7	13	10	11	0	2	2	2	2	0	0	2	2	2	2	4	2	2	3	4	2	2	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:56468821G>T	uc003dhr.1	-	2	471	c.215C>A	c.(214-216)TCA>TAA	p.S72*		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	72						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTAGGTTGTTGAAGCCACCCC	0.507													46	70					6.7651e-33	1.96888e-32	1	0	T	56468821	T	T	56468821	4	4	274	1	0	0	0	0	0	1	0	0	5235	1294	45	2	2712	2	ERC2	3	56468821	Nonsense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	8764950	56468821	141553609	24	49704											
CLSTN2	64084	broad.mit.edu	37	chr3	140251315	140251315	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatgcaactcacagtcggCgcttgttggcaaggtaatcc	9	9	11	12	2	1	0	1	0	0	0	3	0	2	0	2	3	2	5	2	3	3	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:140251315C>A	uc003etn.2	+	9	1684	c.1494C>A	c.(1492-1494)GGC>GGA	p.G498G	CLSTN2_uc003etm.2_Silent_p.G498G	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	498	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TCACAGTCGGCGCTTGTTGGC	0.443										HNSCC(16;0.037)			24	72					0.000117367	0.000309555	1	0	A	140251315	A	A	140251315	2	1	274	1	0	0	0	0	0	0	0	1	3577	755	27	3		3	CLSTN2	3	140251315	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	83782494	140251315	57771115	25	49705											
YEATS2	55689	broad.mit.edu	37	chr3	183469895	183469895	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actccatcgccattctctcgGagaagactgtatctatcctc	9	12	6	14	2	2	2	0	0	2	2	8	3	4	2	3	1	0	1	3	1	3	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:183469895G>A	uc003fly.2	+	10	1199	c.1004G>A	c.(1003-1005)GGA>GAA	p.G335E		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	335					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CATTCTCTCGGAGAAGACTGT	0.493													49	117					0	0	0	0	A	183469895	A	A	183469895	3	1	274	1	0	0	0	0	1	0	0	0	17540	1174	41	2	1038	2	YEATS2	3	183469895	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	43218580	183469895	14552535	26	49706											
EIF4G1	1981	broad.mit.edu	37	chr3	184043328	184043328	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccattgaccagatccataagGaggctgagatggaagaacat	15	7	11	8	0	0	4	0	2	0	3	1	7	1	6	3	3	1	1	3	3	3	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:184043328G>T	uc003fnp.2	+	20	3220	c.3022G>T	c.(3022-3024)GAG>TAG	p.E1008*	EIF4G1_uc003fnt.2_Nonsense_Mutation_p.E719*|EIF4G1_uc003fnq.2_Nonsense_Mutation_p.E921*|EIF4G1_uc003fnr.2_Nonsense_Mutation_p.E844*|EIF4G1_uc010hxx.2_Nonsense_Mutation_p.E1015*|EIF4G1_uc003fns.2_Nonsense_Mutation_p.E968*|EIF4G1_uc010hxy.2_Nonsense_Mutation_p.E1015*|EIF4G1_uc003fnv.3_Nonsense_Mutation_p.E1009*|EIF4G1_uc003fnu.3_Nonsense_Mutation_p.E1008*|EIF4G1_uc003fnw.2_Nonsense_Mutation_p.E1015*|EIF4G1_uc003fnx.2_Nonsense_Mutation_p.E813*|EIF4G1_uc003fny.3_Nonsense_Mutation_p.E812*|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1008	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GATCCATAAGGAGGCTGAGAT	0.587													48	122					5.48756e-27	1.57534e-26	1	0	T	184043328	T	T	184043328	4	4	274	1	0	0	0	0	0	1	0	0	5060	1175	41	2	3092	2	EIF4G1	3	184043328	Nonsense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	573433	184043328	13979102	27	49707											
EIF4G1	1981	broad.mit.edu	37	chr3	184045463	184045463	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaatccaaggctatcattGaggaatatctccatctcaat	15	11	6	9	0	3	2	2	1	2	1	6	3	4	3	2	2	0	1	2	2	6	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:184045463G>C	uc003fnp.2	+	25	3949	c.3751G>C	c.(3751-3753)GAG>CAG	p.E1251Q	EIF4G1_uc003fnt.2_Missense_Mutation_p.E962Q|EIF4G1_uc003fnq.2_Missense_Mutation_p.E1164Q|EIF4G1_uc003fnr.2_Missense_Mutation_p.E1087Q|EIF4G1_uc010hxx.2_Missense_Mutation_p.E1258Q|EIF4G1_uc003fns.2_Missense_Mutation_p.E1211Q|EIF4G1_uc010hxy.2_Missense_Mutation_p.E1258Q|EIF4G1_uc003fnv.3_Missense_Mutation_p.E1252Q|EIF4G1_uc003fnu.3_Missense_Mutation_p.E1251Q|EIF4G1_uc003fnw.2_Missense_Mutation_p.E1258Q|EIF4G1_uc003fnx.2_Missense_Mutation_p.E1056Q|EIF4G1_uc003fny.3_Missense_Mutation_p.E1055Q|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1251	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGCTATCATTGAGGAATATCT	0.557													28	74					0	0	0	0	C	184045463	C	C	184045463	3	2	274	1	0	0	0	0	1	0	0	0	5060	1291	45	2	3841	2	EIF4G1	3	184045463	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	2135	184045463	13976967	28	49708											
HRG	3273	broad.mit.edu	37	chr3	186392970	186392970	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcataaactgtgaagtcttCgaccctcaggtgggttgtct	8	13	11	9	1	4	1	2	1	2	0	5	2	4	1	1	2	1	1	1	2	3	3	rs151028119		TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:186392970C>T	uc003fqq.2	+	6	755	c.732C>T	c.(730-732)TTC>TTT	p.F244F		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	244	Cystatin 2.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		GTGAAGTCTTCGACCCTCAGG	0.428													28	243					0	0	0	0	T	186392970	T	T	186392970	2	4	274	1	0	0	0	0	0	0	0	1	7393	883	31	1		1	HRG	3	186392970	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	2347507	186392970	11629460	29	49709											
LRRC33	375387	broad.mit.edu	37	chr3	196381413	196381413	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacagggctgcccttgagatGgagttgctgcctctttggct	5	12	13	11	0	1	1	0	1	1	1	1	3	1	2	2	3	3	4	2	3	0	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr3:196381413G>A	uc003fwv.2	+	2	107	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	1						integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CCCTTGAGATGGAGTTGCTGC	0.567													13	58					0	0	0	0	A	196381413	A	A	196381413	3	1	274	1	0	0	0	0	1	0	0	0	9038	1348	47	4	5	4	LRRC33	3	196381413	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	9988443	196381413	1641017	30	49710											
FRYL	285527	broad.mit.edu	37	chr4	48622739	48622739	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtctgtaccagtcaaacaaGgtgcgaagtaaggaagggag	14	6	14	7	2	2	0	1	0	1	0	2	3	2	2	1	3	3	2	1	3	6	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:48622739G>A	uc003gyh.1	-	6	836	c.231C>T	c.(229-231)ACC>ACT	p.T77T	FRYL_uc003gyk.2_Silent_p.T77T|FRYL_uc003gyl.1_Silent_p.T128T|FRYL_uc003gym.1_Silent_p.T77T	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AGTCAAACAAGGTGCGAAGTA	0.398													26	48					0	0	0	0	A	48622739	A	A	48622739	2	1	274	1	0	0	0	0	0	0	0	1	6098	987	35	4		4	FRYL	4	48622739	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08		48622739	142531537	31	49711											
HELQ	113510	broad.mit.edu	37	chr4	84352817	84352817	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaatttaagaaaaatacCttcaaaccaatcaaagagag	24	7	4	6	0	2	2	2	0	0	2	2	3	2	2	2	0	2	0	2	0	10	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:84352817C>T	uc003hom.2	-	11	2474	c.2295G>A	c.(2293-2295)AAG>AAA	p.K765K	HELQ_uc010ikb.2_Silent_p.K698K|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	765							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						AGAAAAATACCTTCAAACCAA	0.289								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					12	29					0	0	0	0	T	84352817	T	T	84352817	2	4	274	1	0	0	0	0	0	0	0	1	7086	695	24	4		4	HELQ	4	84352817	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	35730078	84352817	106801459	32	49712											
WDFY3	23001	broad.mit.edu	37	chr4	85707147	85707147	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttacctgcttagcaatggcTttgctatccaatttgttata	9	17	6	9	0	0	0	0	0	0	0	1	0	1	0	2	1	4	5	2	1	7	7			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:85707147T>C	uc003hpd.2	-	24	4455	c.4047A>G	c.(4045-4047)AAA>AAG	p.K1349K		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1349						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TAGCAATGGCTTTGCTATCCA	0.418													24	46					0	0	0	0	C	85707147	C	C	85707147	2	2	274	1	0	0	0	0	0	0	0	1	17338	1606	56	5		5	WDFY3	4	85707147	Silent	SNP	T	TCGA-CX-7219-01A-11D-2012-08	1354330	85707147	105447129	33	49713											
AFF1	4299	broad.mit.edu	37	chr4	87968051	87968051	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactagtgtccaccaccagTccattcacactcctgcgtct	9	10	5	17	1	2	0	1	0	1	0	5	0	5	0	5	0	1	0	5	0	1	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:87968051T>C	uc003hqj.3	+	3	750	c.343T>C	c.(343-345)TCC>CCC	p.S115P	AFF1_uc011ccx.1_Missense_Mutation_p.S56P|AFF1_uc003hqh.1_Missense_Mutation_p.S122P|AFF1_uc011ccy.1_Missense_Mutation_p.S122P|AFF1_uc011ccz.1_Missense_Mutation_p.S122P|AFF1_uc003hqk.3_Missense_Mutation_p.S115P|AFF1_uc011cda.1_Intron	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	115						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CCACCACCAGTCCATTCACAC	0.488													18	98					0	0	0	0	C	87968051	C	C	87968051	3	2	274	1	0	0	0	0	1	0	0	0	356	1667	58	5	395	5	AFF1	4	87968051	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08	2260904	87968051	103186225	34	49714											
SPP1	6696	broad.mit.edu	37	chr4	88903947	88903947	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatgaatttcacagccatGaagatatgctggttgtagac	12	11	10	8	0	1	4	1	2	0	2	1	4	1	4	2	1	2	3	2	1	4	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:88903947G>T	uc003hra.2	+	7	1009	c.844G>T	c.(844-846)GAA>TAA	p.E282*	SPP1_uc003hrb.2_Nonsense_Mutation_p.E255*|SPP1_uc003hrc.2_Nonsense_Mutation_p.E268*|SPP1_uc011cde.1_Nonsense_Mutation_p.E295*|SPP1_uc003hrd.2_Nonsense_Mutation_p.E241*	NM_001040058	NP_001035147	P10451	OSTP_HUMAN	secreted phosphoprotein 1 isoform a	282					biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			ovary(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)		TCACAGCCATGAAGATATGCT	0.398													11	108					0.00185496	0.0047442	1	0	T	88903947	T	T	88903947	4	4	274	1	0	0	0	0	0	1	0	0	15152	1291	45	2	866	2	SPP1	4	88903947	Nonsense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	935896	88903947	102250329	35	49715											
ENPEP	2028	broad.mit.edu	37	chr4	111397718	111397718	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgactccagcggggacggcGggccgggcactgcgccagct	5	4	18	14	5	0	1	0	1	0	0	1	2	1	2	3	5	3	2	3	5	0	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr4:111397718G>A	uc003iab.3	+	1	490	c.148G>A	c.(148-150)GGG>AGG	p.G50R		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	50	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CGGGGACGGCGGGCCGGGCAC	0.642													38	108					0	0	0	0	A	111397718	A	A	111397718	3	1	274	1	0	0	0	0	1	0	0	0	5152	1116	39	1	150	1	ENPEP	4	111397718	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	22493771	111397718	79756558	36	49716											
RXFP3	51289	broad.mit.edu	37	chr5	33937017	33937017	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agctggggctggagttgccgGacggcgcgccgccaggacat	6	5	18	12	5	0	0	0	0	0	0	0	3	0	3	3	6	2	3	3	6	0	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:33937017G>T	uc003jic.1	+	1	529	c.172G>T	c.(172-174)GAC>TAC	p.D58Y		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	58	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GGAGTTGCCGGACGGCGCGCC	0.687													41	59					1.15505e-17	3.24954e-17	1	0	T	33937017	T	T	33937017	3	4	274	1	0	0	0	0	1	0	0	0	13826	1174	41	2	174	2	RXFP3	5	33937017	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08		33937017	146978243	37	49717											
SKP2	6502	broad.mit.edu	37	chr5	36152987	36152987	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcatgggggtctccgccctGgagaaagaggagcccgacag	9	4	17	11	2	1	2	0	0	1	2	2	5	1	3	3	5	1	1	3	5	1	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:36152987G>C	uc003jkc.1	+	2	305	c.123G>C	c.(121-123)CTG>CTC	p.L41L	SKP2_uc011cou.1_5'UTR|SKP2_uc003jkd.2_Silent_p.L41L|LMBRD2_uc003jkb.1_5'Flank	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	41					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCTCCGCCCTGGAGAAAGAGG	0.592													14	43					0	0	0	0	C	36152987	C	C	36152987	2	2	274	1	0	0	0	0	0	0	0	1	14427	1335	47	4		4	SKP2	5	36152987	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	2215970	36152987	144762273	38	49718											
CCNB1	891	broad.mit.edu	37	chr5	68471233	68471233	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttgtttcaggttgatgtcGagcaacatactttggccaaa	10	15	9	7	1	1	1	1	1	0	0	2	2	1	1	1	2	3	3	1	2	3	6			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:68471233G>A	uc003jvm.2	+	7	1129	c.952G>A	c.(952-954)GAG>AAG	p.E318K	CCNB1_uc011crd.1_Missense_Mutation_p.E318K|CCNB1_uc010ixb.2_Missense_Mutation_p.E318K	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	318					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		GGTTGATGTCGAGCAACATAC	0.393													23	79					0	0	0	0	A	68471233	A	A	68471233	3	1	274	1	0	0	0	0	1	0	0	0	2926	1059	37	1	978	1	CCNB1	5	68471233	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	32318246	68471233	112444027	39	49719											
RGNEF	64283	broad.mit.edu	37	chr5	73205674	73205674	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgggccactggaagcaCggccggcagaggagcctgcc	7	4	16	14	2	0	1	0	0	0	1	0	3	0	3	4	5	4	3	4	5	1	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:73205674C>T	uc011csq.1	+	33	4610	c.4599C>T	c.(4597-4599)CAC>CAT	p.H1533H	RGNEF_uc003kcx.2_Silent_p.H1533H|RGNEF_uc010izf.2_Silent_p.H1533H|RGNEF_uc011csr.1_Silent_p.H1220H|RGNEF_uc003kcz.3_Silent_p.H497H|RGNEF_uc003kda.3_Silent_p.H453H	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	1533	Interaction with microtubules (By similarity).				cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		ACTGGAAGCACGGCCGGCAGA	0.706													7	6					0	0	0	0	T	73205674	T	T	73205674	2	4	274	1	0	0	0	0	0	0	0	1	13348	535	19	1		1	RGNEF	5	73205674	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	4734441	73205674	107709586	40	49720											
ERAP1	51752	broad.mit.edu	37	chr5	96121617	96121617	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtaatgcacaatgtaataGccattcatgcccacattaaa	15	11	5	10	1	1	0	1	0	0	0	2	0	1	0	2	0	3	3	2	0	6	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:96121617G>A	uc003kmm.2	-	13	2165	c.1818C>T	c.(1816-1818)GGC>GGT	p.G606G	ERAP1_uc003kml.2_Silent_p.G606G|ERAP1_uc010jbm.1_Silent_p.G418G|ERAP1_uc003kmn.2_Silent_p.G606G	NM_001040458	NP_001035548	Q9NZ08	ERAP1_HUMAN	type 1 tumor necrosis factor receptor shedding	606	Lumenal (Potential).				angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		CAATGTAATAGCCATTCATGC	0.428													30	31					0	0	0	0	A	96121617	A	A	96121617	2	1	274	1	0	0	0	0	0	0	0	1	5227	958	34	4		4	ERAP1	5	96121617	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	22915943	96121617	84793643	41	49721											
SEC24A	10802	broad.mit.edu	37	chr5	134033594	134033594	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtgttctcttccaggttgtAtttctcggtattcagcaggt	5	18	10	8	1	3	0	1	0	2	0	6	0	4	0	1	3	1	5	1	3	2	7			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:134033594A>G	uc003kzs.2	+	15	2401	c.2113A>G	c.(2113-2115)ATT>GTT	p.I705V	SEC24A_uc011cxu.1_Missense_Mutation_p.I469V	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	705					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCCAGGTTGTATTTCTCGGTA	0.373													47	50					0	0	0	0	G	134033594	G	G	134033594	3	3	274	1	0	0	0	0	1	0	0	0	14059	449	16	5	2171	5	SEC24A	5	134033594	Missense_Mutation	SNP	A	TCGA-CX-7219-01A-11D-2012-08	37911977	134033594	46881666	42	49722											
PCDHA10	56139	broad.mit.edu	37	chr5	140236912	140236912	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagctggtggtgaccgcgCgggacgggggctcgcctccg	4	6	19	12	6	0	2	0	2	0	0	2	3	1	3	3	5	1	2	3	5	0	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr5:140236912C>T	uc003lhx.2	+	1	1279	c.1279C>T	c.(1279-1281)CGG>TGG	p.R427W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.R427W|PCDHA10_uc011dad.1_Missense_Mutation_p.R427W	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	427	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGACCGCGCGGGACGGGGG	0.647													8	209					0	0	0	0	T	140236912	T	T	140236912	3	4	274	1	0	0	0	0	1	0	0	0	11574	759	27	1	1281	1	PCDHA10	5	140236912	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	6203318	140236912	40678348	43	49723											
HIST1H3C	8352	broad.mit.edu	37	chr6	26045674	26045674	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaacagctcgcaagtctacCggcggcaaagctccgcgcaa	12	4	10	15	5	1	0	0	0	1	0	3	0	2	0	2	2	4	5	2	2	5	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:26045674C>G	uc003nfv.2	+	1	36	c.36C>G	c.(34-36)ACC>ACG	p.T12T	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	12					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GCAAGTCTACCGGCGGCAAAG	0.547													16	65					0	0	0	0	G	26045674	G	G	26045674	2	3	274	1	0	0	0	0	0	0	0	1	7196	639	23	3		3	HIST1H3C	6	26045674	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08		26045674	145069393	44	49724											
SCAND3	114821	broad.mit.edu	37	chr6	28541559	28541559	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actactgtgttcagaaaaggCatgtcttttcttgacaaaaa	14	13	7	7	0	3	2	1	1	2	1	3	2	3	2	0	1	1	2	0	1	5	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:28541559C>G	uc003nlo.2	-	4	2725	c.2107G>C	c.(2107-2109)GCC>CCC	p.A703P		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	703					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						tcagaaaaggcatgtcttttc	0													2	9					0	0	0	0	G	28541559	G	G	28541559	3	3	274	1	0	0	0	0	1	0	0	0	13941	710	25	4	1874	4	SCAND3	6	28541559	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	2495885	28541559	142573508	45	49725											
OR2H2	7932	broad.mit.edu	37	chr6	29555789	29555789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaacacccagggctggaaaGgactctcttcgtggttgtcc	8	10	12	11	1	1	1	0	1	1	0	4	3	2	3	2	4	1	2	2	4	2	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:29555789G>A	uc003nmr.1	+	1	107	c.68G>A	c.(67-69)AGG>AAG	p.R23K	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	23	Extracellular (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGGCTGGAAAGGACTCTCTTC	0.557													52	150					0	0	0	0	A	29555789	A	A	29555789	3	1	274	1	0	0	0	0	1	0	0	0	11056	1000	35	4	70	4	OR2H2	6	29555789	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	1014230	29555789	141559278	46	49726											
PRIM2	5558	broad.mit.edu	37	chr6	57512605	57512605	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaacccaaaccaagtgtccAgaaaaccaaggatgcatcat	17	6	6	12	0	2	1	2	0	0	1	3	2	3	2	4	1	4	1	4	1	6	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:57512605A>C	uc003pdx.2	+	15	1520	c.1433A>C	c.(1432-1434)CAG>CCG	p.Q478P		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	478					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CCAAGTGTCCAGAAAACCAAG	0.398													44	429					0	0	0	0	C	57512605	C	C	57512605	3	2	274	1	0	0	0	0	1	0	0	0	12553	188	7	5	1483	5	PRIM2	6	57512605	Missense_Mutation	SNP	A	TCGA-CX-7219-01A-11D-2012-08	27956816	57512605	113602462	47	49727											
KHDRBS2	202559	broad.mit.edu	37	chr6	62604557	62604557	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacatattcttcataagcttCatgggctggaggaggaggtg	10	12	13	6	0	3	0	2	0	1	0	3	3	3	3	0	5	2	2	0	5	3	6			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:62604557C>A	uc003peg.2	-	6	1040	c.793G>T	c.(793-795)GAA>TAA	p.E265*		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TCATAAGCTTCATGGGCTGGA	0.478													19	63					6.44725e-10	1.76671e-09	1	0	A	62604557	A	A	62604557	4	1	274	1	0	0	0	0	0	1	0	0	8186	835	29	2	272	2	KHDRBS2	6	62604557	Nonsense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	5091952	62604557	108510510	48	49728											
IRAK1BP1	134728	broad.mit.edu	37	chr6	79607895	79607895	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcaaagaagaagaaacaaaAgaatgggaaggccaaataga	24	3	10	4	0	1	5	1	0	0	5	1	6	1	6	1	2	1	0	1	2	10	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:79607895A>G	uc003pim.2	+	4	732	c.627A>G	c.(625-627)AAA>AAG	p.K209K	IRAK1BP1_uc010kbg.1_Intron|IRAK1BP1_uc003pin.2_Silent_p.K122K	NM_001010844	NP_001010844	Q5VVH5	IKBP1_HUMAN	interleukin-1 receptor-associated kinase 1	209					I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0		all_cancers(76;0.0398)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)		BRCA - Breast invasive adenocarcinoma(397;0.21)		AAGAAACAAAAGAATGGGAAG	0.388													10	18					0	0	0	0	G	79607895	G	G	79607895	2	3	274	1	0	0	0	0	0	0	0	1	7861	69	3	5		5	IRAK1BP1	6	79607895	Silent	SNP	A	TCGA-CX-7219-01A-11D-2012-08	17003338	79607895	91507172	49	49729											
DOPEY1	23033	broad.mit.edu	37	chr6	83838721	83838721	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatacaatatcaagcagaccGaactgatgatattgacagag	17	9	8	7	1	1	5	1	3	0	2	1	6	1	5	1	0	3	1	1	0	7	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:83838721G>T	uc003pjs.1	+	16	2095	c.1835G>T	c.(1834-1836)CGA>CTA	p.R612L	DOPEY1_uc011dyy.1_Missense_Mutation_p.R603L|DOPEY1_uc010kbl.1_Missense_Mutation_p.R603L	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	612					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CAAGCAGACCGAACTGATGAT	0.458													39	110					5.44703e-19	1.55314e-18	1	0	T	83838721	T	T	83838721	3	4	274	1	0	0	0	0	1	0	0	0	4729	1058	37	3	1889	3	DOPEY1	6	83838721	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	4230826	83838721	87276346	50	49730											
ASCC3	10973	broad.mit.edu	37	chr6	101054640	101054640	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgggaaaatccacataacGtcttgtttttccatcatagt	13	14	6	8	1	2	0	1	0	1	0	4	1	4	1	2	1	1	1	2	1	5	5	rs112466876		TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:101054640G>A	uc003pqk.2	-	32	5349	c.5020C>T	c.(5020-5022)CGT>TGT	p.R1674C		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1674	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TCCACATAACGTCTTGTTTTT	0.308													23	63					0	0	0	0	A	101054640	A	A	101054640	3	1	274	1	0	0	0	0	1	0	0	0	1035	1145	40	1	1632	1	ASCC3	6	101054640	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	17215919	101054640	70060427	51	49731											
FAM54A	113115	broad.mit.edu	37	chr6	136562633	136562633	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccacaattgctgcaatctGagagcgaagaaaagtcagct	14	9	9	9	1	2	2	1	1	1	2	3	4	3	2	1	0	4	3	1	0	5	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr6:136562633G>C	uc010kgp.1	-	5	853	c.463C>G	c.(463-465)CAG>GAG	p.Q155E	FAM54A_uc003qgt.1_Missense_Mutation_p.Q155E|FAM54A_uc003qgu.1_Missense_Mutation_p.Q112E	NM_001099286	NP_001092756	Q6P444	FA54A_HUMAN	DUF729 domain containing 1	155										skin(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00228)|OV - Ovarian serous cystadenocarcinoma(155;0.00504)		GCTGCAATCTGAGAGCGAAGA	0.343													5	40					0	0	0	0	C	136562633	C	C	136562633	3	2	274	1	0	0	0	0	1	0	0	0	5614	1299	45	2	710	2	FAM54A	6	136562633	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	35507993	136562633	34552434	52	49732											
FERD3L	222894	broad.mit.edu	37	chr7	19184751	19184751	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acctcttccgcgctcctcttCctcctcctcttctccgtccc	1	14	3	23	3	4	0	0	0	4	0	11	0	10	0	8	0	0	1	8	0	0	3	rs71017023		TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:19184751C>T	uc003suo.1	-	1	294	c.235G>A	c.(235-237)GAA>AAA	p.E79K	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	79	Poly-Glu.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						cgctcctcttcctcctcctct	0.363													11	19					0	0	0	0	T	19184751	T	T	19184751	3	4	274	1	0	0	0	0	1	0	0	0	5848	864	30	2	269	2	FERD3L	7	19184751	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08		19184751	139953912	53	49733											
BBS9	27241	broad.mit.edu	37	chr7	33573768	33573768	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtaccgatgcagcagcccCacagaccatggtcatgccag	12	5	10	14	1	1	1	1	0	0	1	1	2	1	1	5	1	5	3	5	1	2	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:33573768C>T	uc003tdn.1	+	21	3014	c.2501C>T	c.(2500-2502)CCA>CTA	p.P834L	BBS9_uc003tdo.1_Missense_Mutation_p.P799L|BBS9_uc003tdp.1_Missense_Mutation_p.P829L|BBS9_uc003tdq.1_Missense_Mutation_p.P794L|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.P358L|BBS9_uc003tds.1_Missense_Mutation_p.P257L|BBS9_uc003tdt.2_RNA	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	834					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GCAGCAGCCCCACAGACCATG	0.478									Bardet-Biedl_syndrome				11	40					0	0	0	0	T	33573768	T	T	33573768	3	4	274	1	0	0	0	0	1	0	0	0	1344	594	21	4	2579	4	BBS9	7	33573768	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	14389017	33573768	125564895	54	49734											
IKZF1	10320	broad.mit.edu	37	chr7	50467751	50467751	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggccgagtccctgcgccCgctggtgcagacgcccccgg	3	4	17	17	5	0	1	0	0	0	1	1	2	1	1	5	4	2	2	5	4	0	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:50467751C>T	uc003tow.3	+	9	1154	c.986C>T	c.(985-987)CCG>CTG	p.P329L	IKZF1_uc003tox.3_Missense_Mutation_p.P287L|IKZF1_uc003toy.3_Missense_Mutation_p.P287L|IKZF1_uc011kck.1_Missense_Mutation_p.P242L|IKZF1_uc003toz.3_Missense_Mutation_p.P299L|IKZF1_uc010kyx.2_Missense_Mutation_p.P69L|IKZF1_uc003tpa.3_Missense_Mutation_p.P71L	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	329					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				TCCCTGCGCCCGCTGGTGCAG	0.652			D		ALL								10	11					0	0	0	0	T	50467751	T	T	50467751	3	4	274	1	0	0	0	0	1	0	0	0	7653	652	23	1	1012	1	IKZF1	7	50467751	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	16893983	50467751	108670912	55	49735											
DDC	1644	broad.mit.edu	37	chr7	50534959	50534959	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgacttccacacagatttCaaagcggggatcctggcgca	12	8	10	11	2	1	2	1	1	0	1	3	3	3	3	2	3	1	1	2	3	2	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:50534959C>A	uc003tpf.3	-	13	1281	c.1195G>T	c.(1195-1197)GAA>TAA	p.E399*	DDC_uc010kza.2_Nonsense_Mutation_p.E314*|DDC_uc003tpg.3_Nonsense_Mutation_p.E399*	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	399					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	ACACAGATTTCAAAGCGGGGA	0.448													42	126					6.5261e-18	1.84833e-17	1	0	A	50534959	A	A	50534959	4	1	274	1	0	0	0	0	0	1	0	0	4342	835	29	2	255	2	DDC	7	50534959	Nonsense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	67208	50534959	108603704	56	49736											
POM121L12	285877	broad.mit.edu	37	chr7	53104149	53104149	+	Frame_Shift_Del	DEL	C	-	-																															gctggtccagcccgccccatCcgccatctgggacttctggg																										TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:53104149delC	uc003tpz.2	+	1	801	c.785delC	c.(784-786)TCCfs	p.S262fs		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	262											0						CCCGCCCCATCCGCCATCTGG	0.657													---	---	---								-	53104149	-	-	53104149	7	5	274	1	0	1	0	1	0	0	0	0	12296	855	30	0	787	0	POM121L12	7	53104149	Frame_Shift_Del	DEL	C	TCGA-CX-7219-01A-11D-2012-08	2569190	53104149	106034514	57	49737											
ZNF679	168417	broad.mit.edu	37	chr7	63720697	63720697	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttatatagagatgtgatgttAgagaactacagaaacctggt	15	12	10	4	0	0	4	0	1	0	3	0	6	0	4	1	1	3	1	1	1	7	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:63720697A>G	uc003tsx.2	+	3	407	c.138A>G	c.(136-138)TTA>TTG	p.L46L		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	46	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATGTGATGTTAGAGAACTACA	0.378													3	74					0	0	0	0	G	63720697	G	G	63720697	2	3	274	1	0	0	0	0	0	0	0	1	18153	417	15	5		5	ZNF679	7	63720697	Silent	SNP	A	TCGA-CX-7219-01A-11D-2012-08	10616548	63720697	95417966	58	49738											
ZAN	7455	broad.mit.edu	37	chr7	100349865	100349865	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacagaaaaacccaccatcTccccagaaaaacccaccatc	17	3	2	19	0	1	2	0	0	1	2	3	2	1	2	7	0	2	0	7	0	4	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:100349865T>C	uc003uwj.2	+	14	2302	c.2137T>C	c.(2137-2139)TCC>CCC	p.S713P	ZAN_uc003uwk.2_Missense_Mutation_p.S713P|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	713	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACCCACCATCTCCCCAGAAAA	0.502													5	111					0	0	0	0	C	100349865	C	C	100349865	3	2	274	1	0	0	0	0	1	0	0	0	17581	1551	54	5	2187	5	ZAN	7	100349865	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08	36629168	100349865	58788798	59	49739											
MLL5	55904	broad.mit.edu	37	chr7	104751259	104751259	+	Frame_Shift_Del	DEL	T	-	-																															aacccacaactacgaatgaaTgtccatccccagatacttct																										TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:104751259delT	uc003vcm.2	+	26	4546	c.4012delT	c.(4012-4014)TGTfs	p.C1338fs	MLL5_uc010ljc.2_Frame_Shift_Del_p.C1338fs|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Frame_Shift_Del_p.C72fs|uc003vcp.1_5'Flank|MLL5_uc010ljh.1_Frame_Shift_Del_p.N101fs	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1338					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						TACGAATGAATGTCCATCCCC	0.358													---	---	---								-	104751259	-	-	104751259	7	5	274	1	0	1	0	1	0	0	0	0	9677	1464	51	0	4106	0	MLL5	7	104751259	Frame_Shift_Del	DEL	T	TCGA-CX-7219-01A-11D-2012-08	4401394	104751259	54387404	60	49740											
LAMB1	3912	broad.mit.edu	37	chr7	107613482	107613482	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacagtcacatggtcgacatCcatccaaatcattgcttaag	13	10	6	12	1	2	0	2	0	0	0	5	1	4	0	2	1	1	1	2	1	2	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:107613482C>A	uc003vew.2	-	13	1852	c.1517G>T	c.(1516-1518)GGA>GTA	p.G506V	LAMB1_uc003vev.2_Missense_Mutation_p.G530V|LAMB1_uc003vex.2_Missense_Mutation_p.G506V|LAMB1_uc010ljn.1_Missense_Mutation_p.G592V	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	506	Laminin EGF-like 4.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGTCGACATCCATCCAAATC	0.458													32	56					2.42023e-17	6.76383e-17	1	0	A	107613482	A	A	107613482	3	1	274	1	0	0	0	0	1	0	0	0	8650	855	30	2	3931	2	LAMB1	7	107613482	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	2862223	107613482	51525181	61	49741											
C7orf60	154743	broad.mit.edu	37	chr7	112472713	112472713	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catcaagtaatctgatttttCctgaggcttgtagcaaccta	11	14	7	9	0	2	2	1	2	1	0	3	2	3	2	2	1	2	4	2	1	5	6			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr7:112472713C>T	uc003vgo.1	-	4	618	c.491G>A	c.(490-492)GGA>GAA	p.G164E	C7orf60_uc011kms.1_Missense_Mutation_p.G190E	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	164										ovary(2)|skin(1)	3						TCTGATTTTTCCTGAGGCTTG	0.294													6	60					0	0	0	0	T	112472713	T	T	112472713	3	4	274	1	0	0	0	0	1	0	0	0	2418	855	30	2	734	2	C7orf60	7	112472713	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	4859231	112472713	46665950	62	49742											
CA1	759	broad.mit.edu	37	chr8	86244757	86244757	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagggcatcaagtactttctGcagctttgggttggcctcac	7	12	12	10	0	3	0	2	0	1	0	3	1	3	0	1	3	3	5	1	3	2	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr8:86244757G>T	uc003ydh.2	-	7	675	c.475C>A	c.(475-477)CAG>AAG	p.Q159K	CA13_uc003ydf.1_Intron|CA1_uc010mae.1_Missense_Mutation_p.Q159K|CA1_uc003ydi.2_Missense_Mutation_p.Q159K	NM_001738	NP_001729	P00915	CAH1_HUMAN	carbonic anhydrase I	159					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	AGTACTTTCTGCAGCTTTGGG	0.328													13	31					7.93312e-07	2.13234e-06	1	0	T	86244757	T	T	86244757	3	4	274	1	0	0	0	0	1	0	0	0	2522	1328	46	4	322	4	CA1	8	86244757	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08		86244757	60119265	63	49743											
VPS13B	157680	broad.mit.edu	37	chr8	100147948	100147948	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcagaatttatcttggattCaactcatcataaggttagag	13	13	8	7	1	4	2	3	0	1	2	4	3	4	3	0	2	1	2	0	2	5	6			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr8:100147948C>T	uc003yiv.2	+	11	1661	c.1550C>T	c.(1549-1551)TCA>TTA	p.S517L	VPS13B_uc003yiw.2_Missense_Mutation_p.S517L|VPS13B_uc003yit.2_Missense_Mutation_p.S517L|VPS13B_uc003yiu.1_Missense_Mutation_p.S517L|VPS13B_uc003yix.1_5'Flank	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	517					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATCTTGGATTCAACTCATCAT	0.348													6	42					0	0	0	0	T	100147948	T	T	100147948	3	4	274	1	0	0	0	0	1	0	0	0	17258	838	29	2	1630	2	VPS13B	8	100147948	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	13903191	100147948	46216074	64	49744											
DPYS	1807	broad.mit.edu	37	chr8	105463606	105463606	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaatggcgaaatcaataatCatggtggtgcctcctgagag	12	9	13	7	1	2	1	2	1	0	1	3	4	3	2	2	4	1	0	2	4	4	1	rs148513732	by1000genomes	TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr8:105463606C>T	uc003yly.3	-	2	420	c.291G>A	c.(289-291)ATG>ATA	p.M97I		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	97					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AATCAATAATCATGGTGGTGC	0.458													43	47					0	0	0	0	T	105463606	T	T	105463606	3	4	274	1	0	0	0	0	1	0	0	0	4768	826	29	2	1300	2	DPYS	8	105463606	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	5315658	105463606	40900416	65	49745											
WISP1	8840	broad.mit.edu	37	chr8	134233036	134233036	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcagtgggtatgtgaggacGacgccaagaggccacgcaag	12	4	16	9	3	0	2	0	1	0	1	0	4	0	3	2	3	1	3	2	3	3	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr8:134233036G>A	uc003yub.2	+	3	638	c.562G>A	c.(562-564)GAC>AAC	p.D188N	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	188					cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			ATGTGAGGACGACGCCAAGAG	0.682													18	86					0	0	0	0	A	134233036	A	A	134233036	3	1	274	1	0	0	0	0	1	0	0	0	17440	1058	37	1	572	1	WISP1	8	134233036	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	28769430	134233036	12130986	66	49746											
PSIP1	11168	broad.mit.edu	37	chr9	15469032	15469033	+	Frame_Shift_Ins	INS	-	G	G																															agtgaagcaagttcatccaaINSggcctcaatgcatctgttca																										TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:15469032_15469033insG	uc003zlv.3	-	13	1458_1459	c.1128_1129insC	c.(1126-1131)GCCTTGfs	p.A376fs	PSIP1_uc003zlw.3_Frame_Shift_Ins_p.A376fs	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	376_377	Potential.				initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		AGTTCATCCAAGGCCTCAATGC	0.361													---	---	---								G	15469033	G	G	15469032	7	5	274	1	0	1	1	0	0	0	0	0	12725	69	3	0	479	0	PSIP1	9	15469032	Frame_Shift_Ins	INS	-	TCGA-CX-7219-01A-11D-2012-08		15469032	125744399	67	49747											
MOBKL2B	79817	broad.mit.edu	37	chr9	27455464	27455464	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgagcccgtttgtgcagctCaaacctctgtgtgccaggtt	6	12	11	12	1	2	1	1	1	1	0	2	1	2	1	3	1	5	4	3	1	1	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:27455464C>T	uc003zqn.2	-	2	581	c.85G>A	c.(85-87)GAG>AAG	p.E29K		NM_024761	NP_079037	Q86TA1	MOL2B_HUMAN	MOB1, Mps One Binder kinase activator-like 2B	29							metal ion binding|protein binding			ovary(1)|pleura(1)	2		all_neural(11;9.12e-11)		Lung(218;6.54e-05)|LUSC - Lung squamous cell carcinoma(38;0.000397)		TTGTGCAGCTCAAACCTCTGT	0.552													42	159					0	0	0	0	T	27455464	T	T	27455464	3	4	274	1	0	0	0	0	1	0	0	0	9738	835	29	2	577	2	MOBKL2B	9	27455464	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	11986432	27455464	113757967	68	49748											
NDUFB6	4712	broad.mit.edu	37	chr9	32558937	32558937	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggacttcttttcaactaTgccatatggtttttcctgta	7	19	6	9	0	3	0	1	0	2	0	4	1	4	1	2	2	2	2	2	2	4	8			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:32558937T>C	uc003zre.1	-	3	413	c.289A>G	c.(289-291)ATA>GTA	p.I97V	NDUFB6_uc003zrf.1_Intron	NM_002493	NP_002484	O95139	NDUB6_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	97					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00199)	NADH(DB00157)	TTTTCAACTATGCCATATGGT	0.224													32	115					0	0	0	0	C	32558937	C	C	32558937	3	2	274	1	0	0	0	0	1	0	0	0	10339	1464	51	5	105	5	NDUFB6	9	32558937	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08	5103473	32558937	108654494	69	49749											
MELK	9833	broad.mit.edu	37	chr9	36599430	36599430	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacagacatgctgtgggagtCtggcttatgcagcacctgag	9	10	13	9	0	1	2	0	1	1	1	1	3	1	3	1	2	4	4	1	2	2	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:36599430C>T	uc003zzn.2	+	7	652	c.514C>T	c.(514-516)CTG>TTG	p.L172L	MELK_uc011lpm.1_Silent_p.L41L|MELK_uc011lpn.1_Silent_p.L172L|MELK_uc011lpo.1_5'UTR|MELK_uc010mll.2_Silent_p.L140L|MELK_uc011lpp.1_Silent_p.L124L|MELK_uc010mlm.2_Silent_p.L101L|MELK_uc011lpq.1_5'UTR|MELK_uc011lpr.1_Silent_p.L101L|MELK_uc011lps.1_Silent_p.L92L	NM_014791	NP_055606	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	172	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			CTGTGGGAGTCTGGCTTATGC	0.299													14	32					0	0	0	0	T	36599430	T	T	36599430	2	4	274	1	0	0	0	0	0	0	0	1	9523	912	32	2		2	MELK	9	36599430	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	4040493	36599430	104614001	70	49750											
C9orf71	169693	broad.mit.edu	37	chr9	71155642	71155642	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagtcgaatatggagcccCaggaaatgaagaaggccccc	14	4	12	11	1	0	2	0	1	0	1	1	6	0	4	4	3	1	0	4	3	5	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:71155642C>G	uc004agt.2	-	1	142	c.89G>C	c.(88-90)TGG>TCG	p.W30S		NM_153237	NP_694969	Q8N6L7	CI071_HUMAN	hypothetical protein LOC169693	30						integral to membrane					0						TATGGAGCCCCAGGAAATGAA	0.522													20	42					0	0	0	0	G	71155642	G	G	71155642	3	3	274	1	0	0	0	0	1	0	0	0	2506	595	21	4	431	4	C9orf71	9	71155642	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	34556212	71155642	70057789	71	49751											
APBA1	320	broad.mit.edu	37	chr9	72131514	72131514	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtcgcgtgcgtccagctcggGcgcgtcccctatctcctcgt	2	10	12	17	7	1	0	0	0	1	0	7	0	3	0	4	1	2	1	4	1	1	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:72131514G>A	uc004ahh.2	-	2	889	c.613C>T	c.(613-615)CCC>TCC	p.P205S		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	205					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						TCCAGCTCGGGCGCGTCCCCT	0.716													7	28					0	0	0	0	A	72131514	A	A	72131514	3	1	274	1	0	0	0	0	1	0	0	0	756	1203	42	4	1948	4	APBA1	9	72131514	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	975872	72131514	69081917	72	49752											
LPAR1	1902	broad.mit.edu	37	chr9	113637831	113637831	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcagcagaggatctgcctaAaggtggcgctcatttctttg	8	11	13	9	1	3	1	1	0	2	1	3	2	3	2	1	4	2	3	1	4	2	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:113637831A>G	uc004bfa.2	-	5	1220	c.965T>C	c.(964-966)TTT>TCT	p.F322S	LPAR1_uc011lwm.1_Missense_Mutation_p.F323S|LPAR1_uc004bfb.2_Missense_Mutation_p.F322S|LPAR1_uc004bfc.2_Missense_Mutation_p.F322S|LPAR1_uc011lwn.1_Missense_Mutation_p.F304S|LPAR1_uc011lwo.1_Missense_Mutation_p.F323S|LPAR1_uc010mub.2_Missense_Mutation_p.F322S	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	322	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						GATCTGCCTAAAGGTGGCGCT	0.552													4	141					0	0	0	0	G	113637831	G	G	113637831	3	3	274	1	0	0	0	0	1	0	0	0	8954	14	1	5	133	5	LPAR1	9	113637831	Missense_Mutation	SNP	A	TCGA-CX-7219-01A-11D-2012-08	41506317	113637831	27575600	73	49753											
HSPA5	3309	broad.mit.edu	37	chr9	128003180	128003180	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgcggccgttcttgaacacGccgacgctggcagaaaaacc	11	5	11	14	6	1	2	0	1	1	1	1	3	1	2	3	2	2	3	3	2	3	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:128003180G>C	uc004bpn.2	-	2	385	c.129C>G	c.(127-129)GGC>GGG	p.G43G		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	43					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	TCTTGAACACGCCGACGCTGG	0.632										Prostate(1;0.17)			9	114					0	0	0	0	C	128003180	C	C	128003180	2	2	274	1	0	0	0	0	0	0	0	1	7453	1074	38	3		3	HSPA5	9	128003180	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	14365349	128003180	13210251	74	49754											
ODF2	4957	broad.mit.edu	37	chr9	131221882	131221882	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaacggagtaacgagtctCacgcagaaaaaggtcttgag	16	6	12	7	3	2	3	1	1	2	2	3	5	2	4	0	2	2	2	0	2	5	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:131221882C>T	uc011mbd.1	+	3	380	c.69C>T	c.(67-69)CTC>CTT	p.L23L	ODF2_uc011maz.1_Silent_p.L23L|ODF2_uc011mba.1_5'UTR|ODF2_uc010myb.2_5'UTR|ODF2_uc011mbb.1_5'UTR|ODF2_uc011mbc.1_5'UTR|ODF2_uc004bva.2_5'UTR|ODF2_uc004bvb.2_5'UTR|ODF2_uc011mbe.1_5'UTR|ODF2_uc004bvc.2_5'UTR|ODF2_uc010myc.2_Silent_p.L23L|ODF2_uc011mbf.1_Silent_p.L23L|ODF2_uc004bvd.3_Silent_p.L23L|ODF2_uc004bve.2_Silent_p.L23L	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	23					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						TAACGAGTCTCACGCAGAAAA	0.493													9	22					0	0	0	0	T	131221882	T	T	131221882	2	4	274	1	0	0	0	0	0	0	0	1	10881	813	29	2		2	ODF2	9	131221882	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	3218702	131221882	9991549	75	49755											
BAT2L1	84726	broad.mit.edu	37	chr9	134308054	134308054	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaagttgctgcagcccggCgcatgccaccgcctgcaaac	9	5	12	15	3	0	0	0	0	0	0	0	1	0	1	4	2	6	5	4	2	2	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:134308054C>T	uc004can.3	+	2	221	c.166C>T	c.(166-168)CGC>TGC	p.R56C	BAT2L1_uc004cam.1_Missense_Mutation_p.R56C	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	56							protein binding				0						TGCAGCCCGGCGCATGCCACC	0.527													34	33					0	0	0	0	T	134308054	T	T	134308054	3	4	274	1	0	0	0	0	1	0	0	0	1322	768	27	1	172	1	BAT2L1	9	134308054	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	3086172	134308054	6905377	76	49756											
SURF4	6836	broad.mit.edu	37	chr9	136234196	136234196	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcaggtagccgcagttccaGgtggtgtcgatgtagtcgcg	7	9	16	9	4	0	0	0	0	0	0	3	1	1	0	2	3	2	5	2	3	2	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr9:136234196G>A	uc004cdj.2	-	2	304	c.174C>T	c.(172-174)ACC>ACT	p.T58T	SURF4_uc011mda.1_Silent_p.T49T|SURF4_uc010nal.2_Silent_p.T90T|SURF4_uc011mdb.1_Silent_p.T15T|SURF4_uc011mdc.1_Silent_p.T15T|SURF4_uc011mdd.1_Silent_p.T58T	NM_033161	NP_149351	O15260	SURF4_HUMAN	surfeit 4	58						endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		CGCAGTTCCAGGTGGTGTCGA	0.617													25	64					0	0	0	0	A	136234196	A	A	136234196	2	1	274	1	0	0	0	0	0	0	0	1	15471	987	35	4		4	SURF4	9	136234196	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	1926142	136234196	4979235	77	49757											
PCDH15	65217	broad.mit.edu	37	chr10	55955493	55955493	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttaaaggtgaagtcaaatTgagactgtccgaaatggttg	13	12	11	5	1	2	2	1	2	1	1	3	4	3	2	1	2	0	1	1	2	5	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr10:55955493T>G	uc001jju.1	-	11	1650	c.1255A>C	c.(1255-1257)AAT>CAT	p.N419H	PCDH15_uc010qhq.1_Missense_Mutation_p.N424H|PCDH15_uc010qhr.1_Missense_Mutation_p.N419H|PCDH15_uc010qhs.1_Missense_Mutation_p.N424H|PCDH15_uc010qht.1_Missense_Mutation_p.N419H|PCDH15_uc010qhu.1_Missense_Mutation_p.N419H|PCDH15_uc001jjv.1_Missense_Mutation_p.N397H|PCDH15_uc010qhv.1_Missense_Mutation_p.N419H|PCDH15_uc010qhw.1_Missense_Mutation_p.N382H|PCDH15_uc010qhx.1_Missense_Mutation_p.N419H|PCDH15_uc010qhy.1_Missense_Mutation_p.N424H|PCDH15_uc010qhz.1_Missense_Mutation_p.N419H|PCDH15_uc010qia.1_Missense_Mutation_p.N397H|PCDH15_uc010qib.1_Missense_Mutation_p.N397H|PCDH15_uc001jjw.2_Missense_Mutation_p.N419H	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	419	Cadherin 4.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GAAGTCAAATTGAGACTGTCC	0.368										HNSCC(58;0.16)			14	43					0	0	0	0	G	55955493	G	G	55955493	3	3	274	1	0	0	0	0	1	0	0	0	11565	1812	63	5	6348	5	PCDH15	10	55955493	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08		55955493	79579254	78	49758											
TET1	80312	broad.mit.edu	37	chr10	70333694	70333694	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcactgggtatagcccaactCtctcaggctggtcctagcaa	9	10	9	13	0	3	0	2	0	1	0	5	0	4	0	2	3	3	3	2	3	5	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr10:70333694C>T	uc001jok.3	+	2	2104	c.1599C>T	c.(1597-1599)CTC>CTT	p.L533L		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	533	Sufficient for binding to genomic CpG islands.				DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TAGCCCAACTCTCTCAGGCTG	0.522													11	74					0	0	0	0	T	70333694	T	T	70333694	2	4	274	1	0	0	0	0	0	0	0	1	15835	900	32	2		2	TET1	10	70333694	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	14378201	70333694	65201053	79	49759											
KIF20B	9585	broad.mit.edu	37	chr10	91532579	91532579	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatctcctattgatatatcAggccaagtggtaagctagta	12	13	8	8	0	3	1	2	1	1	0	4	1	3	1	2	2	1	3	2	2	7	7			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr10:91532579A>G	uc001kgs.1	+	32	5448	c.5376A>G	c.(5374-5376)TCA>TCG	p.S1792S	KIF20B_uc001kgr.1_Silent_p.S1752S|KIF20B_uc001kgt.1_Silent_p.S1003S|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1792	Interaction with PIN1.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						TTGATATATCAGGCCAAGTGG	0.328													3	88					0	0	0	0	G	91532579	G	G	91532579	2	3	274	1	0	0	0	0	0	0	0	1	8326	175	7	5		5	KIF20B	10	91532579	Silent	SNP	A	TCGA-CX-7219-01A-11D-2012-08	21198885	91532579	44002168	80	49760											
PDCD11	22984	broad.mit.edu	37	chr10	105179454	105179454	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctcaggtcttagcggactgGccccaaaagctgtaagttca	10	9	10	12	1	3	0	2	0	1	0	3	1	3	1	3	3	2	3	3	3	4	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr10:105179454G>T	uc001kwy.1	+	16	2353	c.2266G>T	c.(2266-2268)GCC>TCC	p.A756S		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	756	S1 motif 8.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TAGCGGACTGGCCCCAAAAGC	0.488													10	54					4.68919e-08	1.27667e-07	1	0	T	105179454	T	T	105179454	3	4	274	1	0	0	0	0	1	0	0	0	11671	1203	42	4	2324	4	PDCD11	10	105179454	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	13646875	105179454	30355293	81	49761											
PHRF1	57661	broad.mit.edu	37	chr11	605263	605263	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggagctgcctctctgtctCtgtttggagatccttatgag	5	16	11	9	0	2	2	0	1	2	1	5	4	3	3	2	2	2	2	2	2	1	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:605263C>G	uc001lqe.2	+	11	1428	c.1297C>G	c.(1297-1299)CTG>GTG	p.L433V	PHRF1_uc010qwc.1_Missense_Mutation_p.L433V|PHRF1_uc010qwd.1_Missense_Mutation_p.L432V|PHRF1_uc010qwe.1_Missense_Mutation_p.L429V|PHRF1_uc009ybz.1_Missense_Mutation_p.L224V|PHRF1_uc009yca.1_5'Flank	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	433							RNA polymerase binding|zinc ion binding				0						CTCTCTGTCTCTGTTTGGAGA	0.607													38	97					0	0	0	0	G	605263	G	G	605263	3	3	274	1	0	0	0	0	1	0	0	0	11916	912	32	2	1335	2	PHRF1	11	605263	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08		605263	134401253	82	49762											
BRSK2	9024	broad.mit.edu	37	chr11	1475777	1475777	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggaggagcagatcttcgTggtcatcaaagacaaacctc	14	7	11	9	1	3	2	2	0	1	2	5	5	3	4	1	3	2	1	1	3	3	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:1475777T>C	uc001lti.2	+	16	1993	c.1607T>C	c.(1606-1608)GTG>GCG	p.V536A	BRSK2_uc009ycv.1_Missense_Mutation_p.V558A|BRSK2_uc001lth.1_Missense_Mutation_p.V536A|BRSK2_uc001ltj.2_Missense_Mutation_p.V536A|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Missense_Mutation_p.V536A|BRSK2_uc001ltm.2_Missense_Mutation_p.V582A|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA|BRSK2_uc009ycw.2_Missense_Mutation_p.V32A	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	536					establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		CAGATCTTCGTGGTCATCAAA	0.602													12	41					0	0	0	0	C	1475777	C	C	1475777	3	2	274	1	0	0	0	0	1	0	0	0	1529	1696	59	5	1669	5	BRSK2	11	1475777	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08	870514	1475777	133530739	83	49763											
IPO7	10527	broad.mit.edu	37	chr11	9435863	9435863	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagcattttctgccagttCtaaaggatcgttttatccag	9	15	8	9	1	2	0	0	0	2	0	4	1	3	1	2	1	3	4	2	1	3	6			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:9435863C>T	uc001mho.2	+	5	683	c.541C>T	c.(541-543)CTA>TTA	p.L181L		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	181					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TCTGCCAGTTCTAAAGGATCG	0.388													20	60					0	0	0	0	T	9435863	T	T	9435863	2	4	274	1	0	0	0	0	0	0	0	1	7836	912	32	2		2	IPO7	11	9435863	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	7960086	9435863	125570653	84	49764											
MRGPRX3	117195	broad.mit.edu	37	chr11	18159571	18159571	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaccccatcatttacttcttCgtgggctcctttaggcagcg	7	13	8	13	2	2	0	1	0	1	0	4	0	3	0	3	2	3	2	3	2	3	6			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:18159571C>T	uc001mnu.2	+	3	1183	c.822C>T	c.(820-822)TTC>TTT	p.F274F		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	274	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						TTTACTTCTTCGTGGGCTCCT	0.512													30	89					0	0	0	0	T	18159571	T	T	18159571	2	4	274	1	0	0	0	0	0	0	0	1	9821	883	31	1		1	MRGPRX3	11	18159571	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	8723708	18159571	116846945	85	49765											
OR10AG1	282770	broad.mit.edu	37	chr11	55735369	55735369	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacaccaccgctactacatGgactgttatctcattcacaa	14	10	4	13	1	2	0	2	0	1	0	3	1	2	1	2	1	3	2	2	1	5	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:55735369G>A	uc010rit.1	-	1	571	c.571C>T	c.(571-573)CAT>TAT	p.H191Y		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	191	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GCTACTACATGGACTGTTATC	0.398													9	36					0	0	0	0	A	55735369	A	A	55735369	3	1	274	1	0	0	0	0	1	0	0	0	10951	1348	47	4	337	4	OR10AG1	11	55735369	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	37575798	55735369	79271147	86	49766											
TCIRG1	10312	broad.mit.edu	37	chr11	67817516	67817516	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaggcagggggcctggatGatgaagaggaggccgaggtg	12	4	20	5	1	0	3	0	2	0	1	0	6	0	5	2	7	0	1	2	7	3	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:67817516G>A	uc001one.2	+	17	2209	c.2101G>A	c.(2101-2103)GAT>AAT	p.D701N	TCIRG1_uc001ong.2_Missense_Mutation_p.D485N|TCIRG1_uc001onh.2_Missense_Mutation_p.D403N|TCIRG1_uc001oni.2_Missense_Mutation_p.D205N|TCIRG1_uc009ysd.2_RNA	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	701	Lumenal (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						GGGCCTGGATGATGAAGAGGA	0.672													10	27					0	0	0	0	A	67817516	A	A	67817516	3	1	274	1	0	0	0	0	1	0	0	0	15769	1290	45	2	2163	2	TCIRG1	11	67817516	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	12082147	67817516	67189000	87	49767											
GDPD5	81544	broad.mit.edu	37	chr11	75152748	75152748	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagccgctggatgtggcctCtccgcaggctggcgactgcc	4	8	14	15	3	2	0	1	0	1	0	3	2	2	1	4	4	2	3	4	4	0	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:75152748C>T	uc001owo.3	-	14	1805	c.1268G>A	c.(1267-1269)AGA>AAA	p.R423K	GDPD5_uc001owp.3_Missense_Mutation_p.R423K|GDPD5_uc001own.3_Missense_Mutation_p.R178K|GDPD5_uc009yuc.2_Missense_Mutation_p.R285K|GDPD5_uc009yud.2_Missense_Mutation_p.R304K	NM_030792	NP_110419	Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain	423	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			ovary(1)	1						GATGTGGCCTCTCCGCAGGCT	0.672													6	13					0	0	0	0	T	75152748	T	T	75152748	3	4	274	1	0	0	0	0	1	0	0	0	6364	913	32	2	569	2	GDPD5	11	75152748	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	7335232	75152748	59853768	88	49768											
ATM	472	broad.mit.edu	37	chr11	108236053	108236053	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgtgtttttgtccttagtGatattgaccagagtttcaac	8	19	8	6	0	1	3	1	2	0	1	2	3	2	3	2	0	1	2	2	0	3	7			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:108236053G>A	uc001pkb.1	+	63	9374	c.8989G>A	c.(8989-8991)GAT>AAT	p.D2997N	ATM_uc009yxr.1_Missense_Mutation_p.D2997N|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.D1649N	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2997					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TGTCCTTAGTGATATTGACCA	0.398			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			22	33					0	0	0	0	A	108236053	A	A	108236053	3	1	274	1	0	0	0	0	1	0	0	0	1111	1304	45	2	9235	2	ATM	11	108236053	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	33083305	108236053	26770463	89	49769											
CCDC15	80071	broad.mit.edu	37	chr11	124908467	124908467	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaagaaataaaaggaaccaGagaaaaacaacagagagaaa	26	2	8	5	0	1	4	1	0	0	4	1	7	1	5	1	1	3	0	1	1	9	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr11:124908467G>C	uc001qbm.3	+	14	2811	c.2552G>C	c.(2551-2553)AGA>ACA	p.R851T		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	851	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AAAGGAACCAGAGAAAAACAA	0.358													5	1					0	0	0	0	C	124908467	C	C	124908467	3	2	274	1	0	0	0	0	1	0	0	0	2796	942	33	2	2602	2	CCDC15	11	124908467	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	16672414	124908467	10098049	90	49770											
RAD51AP1	10635	broad.mit.edu	37	chr12	4657916	4657916	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggaaaagaaaagcagcatCtaaagctgcagcacagcaga	19	3	11	8	0	1	2	0	0	1	2	1	3	1	3	0	1	6	6	0	1	6	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:4657916C>G	uc001qmw.2	+	7	677	c.521C>G	c.(520-522)TCT>TGT	p.S174C	RAD51AP1_uc001qmu.2_Missense_Mutation_p.S157C|RAD51AP1_uc001qmv.2_Missense_Mutation_p.S120C|RAD51AP1_uc010sep.1_Missense_Mutation_p.S39C|RAD51AP1_uc010seq.1_Missense_Mutation_p.S39C|RAD51AP1_uc009zeg.2_5'Flank	NM_001130862	NP_001124334	Q96B01	R51A1_HUMAN	RAD51 associated protein 1 isoform a	174					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|protein binding|RNA binding|single-stranded DNA binding				0			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			AAAGCAGCATCTAAAGCTGCA	0.413													22	68					0	0	0	0	G	4657916	G	G	4657916	3	3	274	1	0	0	0	0	1	0	0	0	13051	913	32	2	547	2	RAD51AP1	12	4657916	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08		4657916	129193979	91	49771											
ANO2	57101	broad.mit.edu	37	chr12	5744499	5744499	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaccccaaagacgattgaGaatgtcagggcaatctgttt	13	10	9	9	1	3	2	2	1	1	2	3	4	3	2	2	1	0	2	2	1	3	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:5744499G>A	uc001qnm.2	-	17	1707	c.1635C>T	c.(1633-1635)TTC>TTT	p.F545F		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	550	Helical; (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						AGACGATTGAGAATGTCAGGG	0.478													10	16					0	0	0	0	A	5744499	A	A	5744499	2	1	274	1	0	0	0	0	0	0	0	1	697	933	33	2		2	ANO2	12	5744499	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	1086583	5744499	128107396	92	49772											
CLSTN3	9746	broad.mit.edu	37	chr12	7303242	7303242	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagttccggctttcctgctCggaaatgaatggccgttact	8	12	11	10	3	0	1	0	1	0	0	3	3	2	2	3	3	2	4	3	3	4	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:7303242C>T	uc001qsr.2	+	15	2626	c.2348C>T	c.(2347-2349)TCG>TTG	p.S783L	CLSTN3_uc001qss.2_Missense_Mutation_p.S795L	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	783	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						CTTTCCTGCTCGGAAATGAAT	0.547													44	105					0	0	0	0	T	7303242	T	T	7303242	3	4	274	1	0	0	0	0	1	0	0	0	3578	893	31	1	2406	1	CLSTN3	12	7303242	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	1558743	7303242	126548653	93	49773											
SLCO1C1	53919	broad.mit.edu	37	chr12	20893267	20893267	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atcacatcctatactttatcCctaggtggcatacctggata	11	13	6	11	0	1	0	1	0	0	0	3	1	3	1	3	3	2	1	3	3	6	7			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:20893267C>T	uc001rej.3	+	13	2053	c.1698C>T	c.(1696-1698)TCC>TCT	p.S566S	SLCO1C1_uc010sii.1_Silent_p.S566S|SLCO1C1_uc010sij.1_Silent_p.S517S|SLCO1C1_uc009zip.2_Silent_p.S400S|SLCO1C1_uc001rei.2_Silent_p.S566S|SLCO1C1_uc010sik.1_Silent_p.S448S	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	566	Helical; Name=10; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					ATACTTTATCCCTAGGTGGCA	0.378													31	93					0	0	0	0	T	20893267	T	T	20893267	2	4	274	1	0	0	0	0	0	0	0	1	14789	610	22	4		4	SLCO1C1	12	20893267	Silent	SNP	C	TCGA-CX-7219-01A-11D-2012-08	13590025	20893267	112958628	94	49774											
DIP2B	57609	broad.mit.edu	37	chr12	51080375	51080375	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggttggccccggctcaaatgGgttgtaacagattccaagta	10	10	12	9	1	1	1	1	0	0	1	2	1	2	1	3	4	1	5	3	4	4	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:51080375G>A	uc001rwv.2	+	12	1617	c.1461G>A	c.(1459-1461)TGG>TGA	p.W487*	DIP2B_uc009zlt.2_5'UTR	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	487						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GGCTCAAATGGGTTGTAACAG	0.448													17	22					0	0	0	0	A	51080375	A	A	51080375	4	1	274	1	0	0	0	0	0	1	0	0	4550	1241	43	4	1507	4	DIP2B	12	51080375	Nonsense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	30187108	51080375	82771520	95	49775											
HOXC12	3228	broad.mit.edu	37	chr12	54348568	54348568	+	5'Flank	DEL	G	-	-																															agagtgcgggatgggatggtGggggggggggatcggttgtc																										TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:54348568delG	uc010soq.1	+							NM_173860	NP_776272	P31275	HXC12_HUMAN	homeobox C12						multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						ATGGGATGGTGGGGGGGGGGG	0.592													---	---	---								-	54348568	-	-	54348568	6	5	274	0	1	1	0	1	0	0	0	0	7350	1363	47	0		0	HOXC12	12	54348568	5'Flank	DEL	G	TCGA-CX-7219-01A-11D-2012-08	3268193	54348568	79503327	96	49776											
CS	1431	broad.mit.edu	37	chr12	56669923	56669923	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtagagatttcggtagatCtttgctgcaacacaaggtag	11	12	11	7	1	1	2	0	0	1	2	2	3	1	2	0	2	3	5	0	2	5	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:56669923C>G	uc001sks.1	-	7	835	c.645G>C	c.(643-645)AAG>AAC	p.K215N	CS_uc010sql.1_Missense_Mutation_p.K202N|CS_uc001skr.1_Missense_Mutation_p.K149N|CS_uc001skt.1_Missense_Mutation_p.K170N|CS_uc010sqm.1_Missense_Mutation_p.K149N	NM_004077	NP_004068	O75390	CISY_HUMAN	citrate synthase precursor	215					cellular carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	citrate (Si)-synthase activity				0		Myeloproliferative disorder(1001;0.000374)		BRCA - Breast invasive adenocarcinoma(357;6.17e-07)		TTCGGTAGATCTTTGCTGCAA	0.418													21	30					0	0	0	0	G	56669923	G	G	56669923	3	3	274	1	0	0	0	0	1	0	0	0	3939	912	32	2	775	2	CS	12	56669923	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	2321355	56669923	77181972	97	49777											
LRP1	4035	broad.mit.edu	37	chr12	57548365	57548365	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagcaagattgtgtttcctCatggcatcacgctggacctg	9	11	10	11	1	2	1	2	0	0	1	3	2	3	2	2	2	1	4	2	2	1	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:57548365C>T	uc001snd.2	+	8	1574	c.1108C>T	c.(1108-1110)CAT>TAT	p.H370Y	LRP1_uc001snc.1_Missense_Mutation_p.H370Y	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	370	LDL-receptor class B 2.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGTGTTTCCTCATGGCATCAC	0.547													9	10					0	0	0	0	T	57548365	T	T	57548365	3	4	274	1	0	0	0	0	1	0	0	0	9001	826	29	2	1138	2	LRP1	12	57548365	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	878442	57548365	76303530	98	49778											
SFRS8	6433	broad.mit.edu	37	chr12	132239043	132239043	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcgtgccaagaatgatcaaAggtcagaagaagaattttat	16	11	9	5	1	2	5	2	1	0	4	3	5	2	5	1	1	1	0	1	1	7	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:132239043A>G	uc001uja.1	+	9	1593	c.1453A>G	c.(1453-1455)AGA>GGA	p.R485G	SFRS8_uc010tbn.1_Missense_Mutation_p.R485G|SFRS8_uc001ujb.1_Missense_Mutation_p.R278G|SFRS8_uc001uiz.1_3'UTR	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	485	SURP motif 2.				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		GAATGATCAAAGGTCAGAAGA	0.433													23	30					0	0	0	0	G	132239043	G	G	132239043	3	3	274	1	0	0	0	0	1	0	0	0	14248	86	3	5	1487	5	SFRS8	12	132239043	Missense_Mutation	SNP	A	TCGA-CX-7219-01A-11D-2012-08	74690678	132239043	1612852	99	49779											
PUS1	80324	broad.mit.edu	37	chr12	132414283	132414283	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcgcatgggcctccagcttCgcgcgctgttgggagccttc	3	10	14	14	4	0	0	0	0	0	0	3	1	1	1	3	2	3	4	3	2	0	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr12:132414283C>T	uc001ujf.2	+	1	495	c.16C>T	c.(16-18)CGC>TGC	p.R6C	PUS1_uc001ujg.2_Intron|PUS1_uc001ujh.2_Intron|PUS1_uc001uji.2_5'Flank	NM_025215	NP_079491	Q9Y606	TRUA_HUMAN	pseudouridine synthase 1 isoform 1	6						mitochondrion	pseudouridine synthase activity|pseudouridylate synthase activity|RNA binding			breast(1)|central_nervous_system(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.05e-08)|Epithelial(86;2.51e-07)|all cancers(50;2.94e-07)		CCTCCAGCTTCGCGCGCTGTT	0.726													13	15					0	0	0	0	T	132414283	T	T	132414283	3	4	274	1	0	0	0	0	1	0	0	0	12895	884	31	1	18	1	PUS1	12	132414283	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	175240	132414283	1437612	100	49780											
IFT88	8100	broad.mit.edu	37	chr13	21217595	21217595	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttaactgacattgcataagaTatgaattaatggaaaatccc	17	12	6	6	0	0	3	0	2	0	1	1	4	1	4	1	1	2	1	1	1	7	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr13:21217595T>G	uc001unh.2	+	21	2107	c.1711T>G	c.(1711-1713)TAT>GAT	p.Y571D	IFT88_uc001uni.2_Missense_Mutation_p.Y562D|IFT88_uc001unj.2_Missense_Mutation_p.Y561D|IFT88_uc010tcq.1_Missense_Mutation_p.Y542D	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	571	TPR 9.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TTGCATAAGATATGAATTAAT	0.323													20	16					0	0	0	0	G	21217595	G	G	21217595	3	3	274	1	0	0	0	0	1	0	0	0	7605	1420	49	5	1785	5	IFT88	13	21217595	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08		21217595	93952283	101	49781											
SEC23A	10484	broad.mit.edu	37	chr14	39565170	39565170	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggttcatattgaataggtggTaagtcaggtctctctttcag	9	15	11	6	0	5	1	3	1	2	0	6	1	5	1	0	4	0	2	0	4	4	6			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:39565170T>C	uc001wup.1	-	2	376	c.153A>G	c.(151-153)TTA>TTG	p.L51L	SEC23A_uc010tqa.1_Intron|SEC23A_uc010tqb.1_Silent_p.L51L	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	51					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		GAATAGGTGGTAAGTCAGGTC	0.413													14	50					0	0	0	0	C	39565170	C	C	39565170	2	2	274	1	0	0	0	0	0	0	0	1	14056	1635	57	5		5	SEC23A	14	39565170	Silent	SNP	T	TCGA-CX-7219-01A-11D-2012-08		39565170	67784370	102	49782											
FCF1	51077	broad.mit.edu	37	chr14	75199488	75199488	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtacacacaaaggaacctaTgcagatgactgcttagtaca	15	9	8	9	0	0	2	0	1	0	1	0	3	0	3	1	1	5	4	1	1	6	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:75199488T>A	uc001xqh.2	+	6	471	c.420T>A	c.(418-420)TAT>TAA	p.Y140*	FCF1_uc001xqf.1_Nonsense_Mutation_p.Y125*|FCF1_uc001xqg.2_RNA|FCF1_uc001xqi.2_RNA	NM_015962	NP_057046	Q9Y324	FCF1_HUMAN	FCF1 small subunit	140	PINc.				rRNA processing	nucleolus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0037)		AAGGAACCTATGCAGATGACT	0.343													6	76					0	0	0	0	A	75199488	A	A	75199488	4	1	274	1	0	0	0	0	0	1	0	0	5809	1471	51	5	442	5	FCF1	14	75199488	Nonsense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08	35634318	75199488	32150052	103	49783											
ADSSL1	122622	broad.mit.edu	37	chr14	105207565	105207565	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtgccaacgccgccctcCtcgacattgacttcggtatg	7	9	11	14	4	0	1	0	1	0	0	3	2	1	1	4	2	2	1	4	2	2	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:105207565C>T	uc001ypd.2	+	8	852	c.778C>T	c.(778-780)CTC>TTC	p.L260F	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Missense_Mutation_p.L303F|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	260					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CGCCGCCCTCCTCGACATTGA	0.617													20	33					0	0	0	0	T	105207565	T	T	105207565	3	4	274	1	0	0	0	0	1	0	0	0	348	681	24	4	1133	4	ADSSL1	14	105207565	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	30008077	105207565	2141975	104	49784											
AHNAK2	113146	broad.mit.edu	37	chr14	105406529	105406529	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggacctgtggccggtggaGgttcacaccctcacttcctg	5	10	13	13	1	2	0	2	0	0	0	3	2	3	2	4	5	0	1	4	5	0	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:105406529G>A	uc010axc.1	-	7	15379	c.15259C>T	c.(15259-15261)CTC>TTC	p.L5087F	AHNAK2_uc001ypx.2_Missense_Mutation_p.L4987F	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5087						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGCCGGTGGAGGTTCACACCC	0.572													42	95					0	0	0	0	A	105406529	A	A	105406529	3	1	274	1	0	0	0	0	1	0	0	0	415	1000	35	4	2132	4	AHNAK2	14	105406529	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	198964	105406529	1943011	105	49785											
AHNAK2	113146	broad.mit.edu	37	chr14	105410194	105410194	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtttcatgtccacctggCgagcttggaccgtcaggtcg	6	10	14	11	3	2	0	2	0	0	0	4	3	3	2	3	4	1	2	3	4	0	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:105410194C>A	uc010axc.1	-	7	11714	c.11594G>T	c.(11593-11595)CGC>CTC	p.R3865L	AHNAK2_uc001ypx.2_Missense_Mutation_p.R3765L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3865						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTCCACCTGGCGAGCTTGGAC	0.607													82	189					9.35349e-44	2.74109e-43	1	0	A	105410194	A	A	105410194	3	1	274	1	0	0	0	0	1	0	0	0	415	768	27	3	5797	3	AHNAK2	14	105410194	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	3665	105410194	1939346	106	49786											
AHNAK2	113146	broad.mit.edu	37	chr14	105419961	105419962	+	Frame_Shift_Del	DEL	TG	-	-																															tctccttcccttccctgctcTgtgtcttctgtggctttttc																										TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr14:105419961_105419962delTG	uc010axc.1	-	7	1946_1947	c.1826_1827delCA	c.(1825-1827)ACAfs	p.T609fs	AHNAK2_uc001ypx.2_Frame_Shift_Del_p.T509fs	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	609						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTCCCTGCTCTGTGTCTTCTGT	0.475													---	---	---								-	105419962	-	-	105419961	7	5	274	1	0	1	0	1	0	0	0	0	415	1567	55	0	15564	0	AHNAK2	14	105419961	Frame_Shift_Del	DEL	TG	TCGA-CX-7219-01A-11D-2012-08	9767	105419961	1929579	107	49787											
MKRN3	7681	broad.mit.edu	37	chr15	23811447	23811447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttccttgcctgtgattggctCggctgctgaaaggggtttct	4	15	13	9	1	1	2	0	2	1	0	3	2	2	2	2	4	2	4	2	4	1	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr15:23811447C>T	uc001ywh.3	+	1	994	c.518C>T	c.(517-519)TCG>TTG	p.S173L	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.S173L	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	173						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GTGATTGGCTCGGCTGCTGAA	0.612													26	29					0	0	0	0	T	23811447	T	T	23811447	3	4	274	1	0	0	0	0	1	0	0	0	9661	893	31	1	520	1	MKRN3	15	23811447	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08		23811447	78719945	108	49788											
GPR176	11245	broad.mit.edu	37	chr15	40093386	40093386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attgtttctgctcatcttccGctccaccctgcctaccttgg	4	15	6	16	1	3	0	1	0	2	0	5	0	5	0	5	1	3	3	5	1	1	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr15:40093386G>A	uc001zkj.1	-	3	2361	c.1495C>T	c.(1495-1497)CGG>TGG	p.R499W	GPR176_uc010uck.1_Missense_Mutation_p.R439W	NM_007223	NP_009154	Q14439	GP176_HUMAN	G protein-coupled receptor 176	499	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		CTCATCTTCCGCTCCACCCTG	0.512													42	81					0	0	0	0	A	40093386	A	A	40093386	3	1	274	1	0	0	0	0	1	0	0	0	6711	1086	38	1	56	1	GPR176	15	40093386	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	16281939	40093386	62438006	109	49789											
UACA	55075	broad.mit.edu	37	chr15	70960561	70960561	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagctgtttcttaagttcaAcaatattggatttcagagct	12	15	7	7	0	3	1	2	0	1	1	3	2	3	2	0	1	3	4	0	1	4	6			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr15:70960561A>G	uc002asr.2	-	16	2566	c.2462T>C	c.(2461-2463)GTT>GCT	p.V821A	UACA_uc010uke.1_Missense_Mutation_p.V712A|UACA_uc002asq.2_Missense_Mutation_p.V808A|UACA_uc010bin.1_Missense_Mutation_p.V796A	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	821	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						CTTAAGTTCAACAATATTGGA	0.368													3	83					0	0	0	0	G	70960561	G	G	70960561	3	3	274	1	0	0	0	0	1	0	0	0	16892	43	2	5	1804	5	UACA	15	70960561	Missense_Mutation	SNP	A	TCGA-CX-7219-01A-11D-2012-08	30867175	70960561	31570831	110	49790											
MSLN	10232	broad.mit.edu	37	chr16	815234	815234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accccggctggtgagctgccCgggacccctggaccaggacc	6	4	14	17	2	0	1	0	1	0	0	0	4	0	4	7	5	2	2	7	5	0	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:815234C>T	uc002cjw.1	+	8	686	c.635C>T	c.(634-636)CCG>CTG	p.P212L	MSLN_uc002cjt.1_Missense_Mutation_p.P212L|MSLN_uc002cju.1_Missense_Mutation_p.P212L|MSLN_uc010brd.1_Missense_Mutation_p.P211L|MSLN_uc002cjv.1_Missense_Mutation_p.P212L|MSLN_uc002cjx.1_Missense_Mutation_p.P212L|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	212					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane		p.P212P(1)		pancreas(1)	1		Hepatocellular(780;0.00335)				GTGAGCTGCCCGGGACCCCTG	0.697													4	10					0	0	0	0	T	815234	T	T	815234	3	4	274	1	0	0	0	0	1	0	0	0	9934	652	23	1	661	1	MSLN	16	815234	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08		815234	89539519	111	49791											
CASKIN1	57524	broad.mit.edu	37	chr16	2239445	2239445	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catagtgaccatgctgggccGccaggtgcagggggatgtgg	7	7	18	9	1	0	1	0	1	0	0	0	2	0	2	3	5	2	2	3	5	1	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:2239445G>T	uc010bsg.1	-	4	397	c.365C>A	c.(364-366)GCG>GAG	p.A122E		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	122	ANK 3.				signal transduction	cytoplasm				skin(2)	2						ATGCTGGGCCGCCAGGTGCAG	0.547													5	26					0.000602214	0.00155911	1	0	T	2239445	T	T	2239445	3	4	274	1	0	0	0	0	1	0	0	0	2678	1087	38	3	3998	3	CASKIN1	16	2239445	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	1424211	2239445	88115308	112	49792											
DCUN1D3	123879	broad.mit.edu	37	chr16	20871625	20871625	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcttctgttaagaggctaggGaaccgtgcacagattccgtc	9	10	12	10	2	1	2	0	0	1	2	3	3	2	3	2	2	2	4	2	2	3	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:20871625G>A	uc002dhz.2	-	3	639	c.498C>T	c.(496-498)TTC>TTT	p.F166F	ERI2_uc002dht.3_Intron	NM_173475	NP_775746	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain	166	DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				ovary(2)	2				GBM - Glioblastoma multiforme(48;0.249)		AGAGGCTAGGGAACCGTGCAC	0.443													31	67					0	0	0	0	A	20871625	A	A	20871625	2	1	274	1	0	0	0	0	0	0	0	1	4332	1165	41	2		2	DCUN1D3	16	20871625	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	18632180	20871625	69483128	113	49793											
EEF2K	29904	broad.mit.edu	37	chr16	22260121	22260121	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggatgatgaagttctgatCaagatggcatctcaggtgag	11	11	13	6	0	3	5	2	4	2	1	4	6	3	6	0	3	0	2	0	3	2	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:22260121C>G	uc002dki.2	+	4	878	c.393C>G	c.(391-393)ATC>ATG	p.I131M	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	131	Alpha-type protein kinase.				insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		AAGTTCTGATCAAGATGGCAT	0.567													8	35					0	0	0	0	G	22260121	G	G	22260121	3	3	274	1	0	0	0	0	1	0	0	0	4952	816	29	2	403	2	EEF2K	16	22260121	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	1388496	22260121	68094632	114	49794											
CNGB1	1258	broad.mit.edu	37	chr16	58001090	58001090	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctggttccacctccgccTccatctctggctctggttcc	2	14	8	17	1	3	0	0	0	3	0	8	0	7	0	6	3	0	4	6	3	0	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:58001090T>C	uc002emt.2	-	2	166	c.101A>G	c.(100-102)GAG>GGG	p.E34G	CNGB1_uc010cdh.2_Missense_Mutation_p.E34G|CNGB1_uc002emu.2_Missense_Mutation_p.E34G	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	34	Glu-rich.				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						CACCTCCGCCTCCATCTCTGG	0.642													3	81					0	0	0	0	C	58001090	C	C	58001090	3	2	274	1	0	0	0	0	1	0	0	0	3615	1551	54	5	3812	5	CNGB1	16	58001090	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08	35740969	58001090	32353663	115	49795											
CMTM1	113540	broad.mit.edu	37	chr16	66603924	66603924	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacaagtctggaaatctgcaTtgtcgttttttttattctaa	10	18	6	7	1	3	0	0	0	3	0	4	1	3	1	0	1	1	2	0	1	4	7			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr16:66603924T>C	uc002epi.3	+	2	290	c.167T>C	c.(166-168)ATT>ACT	p.I56T	CMTM1_uc002epb.3_RNA|CMTM1_uc002epc.3_RNA|CMTM1_uc002epd.3_Intron|CMTM1_uc002epe.3_Intron|CMTM1_uc002epf.3_Intron|CMTM1_uc002epg.3_Intron|CMTM1_uc002eph.3_Missense_Mutation_p.I56T|CMTM1_uc002epl.3_Intron|CMTM1_uc002epj.3_Intron|CMTM1_uc002epk.3_Intron|CMTM1_uc002epa.3_Intron|CMTM1_uc002epn.3_Missense_Mutation_p.I173T|CMTM1_uc002epo.3_RNA|CMTM1_uc002epp.3_RNA|CMTM1_uc002epq.3_RNA|CMTM1_uc010cds.2_RNA|CMTM1_uc002epr.3_Missense_Mutation_p.I173T|CMTM1_uc002epm.3_RNA|CMTM1_uc002eps.2_RNA	NM_181269	NP_851786	Q8IZ96	CKLF1_HUMAN	chemokine-like factor superfamily 1 isoform 1	56	MARVEL.|Helical; (Potential).				chemotaxis	extracellular space|integral to membrane	cytokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		GAAATCTGCATTGTCGTTTTT	0.343													49	103					0	0	0	0	C	66603924	C	C	66603924	3	2	274	1	0	0	0	0	1	0	0	0	3597	1493	52	5	524	5	CMTM1	16	66603924	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08	8602834	66603924	23750829	116	49796											
TP53	7157	broad.mit.edu	37	chr17	7578262	7578262	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacgcaaatttccttccactCggataagatgctgaggaggg	11	9	11	10	2	0	2	0	1	0	1	3	4	2	4	2	3	1	2	2	3	2	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:7578262C>G	uc002gim.2	-	6	781	c.587G>C	c.(586-588)CGA>CCA	p.R196P	TP53_uc002gig.1_Missense_Mutation_p.R196P|TP53_uc002gih.2_Missense_Mutation_p.R196P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R64P|TP53_uc010cng.1_Missense_Mutation_p.R64P|TP53_uc002gii.1_Missense_Mutation_p.R64P|TP53_uc010cnh.1_Missense_Mutation_p.R196P|TP53_uc010cni.1_Missense_Mutation_p.R196P|TP53_uc002gij.2_Missense_Mutation_p.R196P|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.R103P|TP53_uc002gio.2_Missense_Mutation_p.R64P|TP53_uc010vug.1_Missense_Mutation_p.R157P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(123)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R196L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCTTCCACTCGGATAAGATG	0.547		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	17					0	0	0	0	G	7578262	G	G	7578262	3	3	274	1	0	0	0	0	1	0	0	0	16448	884	31	3	707	3	TP53	17	7578262	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08		7578262	73616948	117	49797											
CCDC144A	9720	broad.mit.edu	37	chr17	16612722	16612722	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagagtttgatttgcaaatgAcaaaaaatatgaaccaaaat	21	10	6	4	0	0	4	0	3	0	1	0	4	0	4	1	0	2	2	1	0	9	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:16612722A>T	uc002gqk.1	+	5	1427	c.1351A>T	c.(1351-1353)ACA>TCA	p.T451S	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	451											0						TTTGCAAATGACAAAAAATAT	0.343													24	26					0	0	0	0	T	16612722	T	T	16612722	3	4	274	1	0	0	0	0	1	0	0	0	2789	275	10	5	1369	5	CCDC144A	17	16612722	Missense_Mutation	SNP	A	TCGA-CX-7219-01A-11D-2012-08	9034460	16612722	64582488	118	49798											
PIGW	284098	broad.mit.edu	37	chr17	34893502	34893502	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgcaatggtttgtctagaGgtcaggaggagaaaatatat	13	12	12	4	0	3	2	1	0	2	2	3	4	3	3	0	4	1	2	0	4	6	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:34893502G>A	uc002hmy.1	+	2	595	c.552G>A	c.(550-552)GAG>GAA	p.E184E	MYO19_uc002hmw.2_5'Flank|MYO19_uc010cuu.2_5'Flank|MYO19_uc010wcy.1_5'Flank|MYO19_uc010wcz.1_5'Flank|MYO19_uc010wda.1_5'Flank|MYO19_uc002hmx.2_5'Flank|PIGW_uc002hmz.1_Silent_p.E184E	NM_178517	NP_848612	Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan, class W	184					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTTGTCTAGAGGTCAGGAGGA	0.418													36	150					0	0	0	0	A	34893502	A	A	34893502	2	1	274	1	0	0	0	0	0	0	0	1	11957	991	35	4		4	PIGW	17	34893502	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	18280780	34893502	46301708	119	49799											
TBX21	30009	broad.mit.edu	37	chr17	45822604	45822604	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagtgattcaggactgggcGaaggagactctaagaggagg	12	6	16	7	1	2	3	1	1	1	2	2	7	2	5	1	5	0	0	1	5	2	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:45822604G>A	uc002ilv.1	+	6	1691	c.1480G>A	c.(1480-1482)GAA>AAA	p.E494K		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	494					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						AGGACTGGGCGAAGGAGACTC	0.617													9	42					0	0	0	0	A	45822604	A	A	45822604	3	1	274	1	0	0	0	0	1	0	0	0	15723	1059	37	1	1502	1	TBX21	17	45822604	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	10929102	45822604	35372606	120	49800											
TRIM37	4591	broad.mit.edu	37	chr17	57119177	57119177	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggagtgacctcattacctgCgggtcctgcagcagctgcat	7	10	12	12	1	1	1	1	1	0	0	2	2	2	2	3	2	6	4	3	2	1	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:57119177C>A	uc002iwy.3	-	17	2194	c.1750G>T	c.(1750-1752)GCA>TCA	p.A584S	TRIM37_uc002iwz.3_Missense_Mutation_p.A584S|TRIM37_uc002ixa.3_Missense_Mutation_p.A462S|TRIM37_uc010woc.1_Missense_Mutation_p.A550S	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	584						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TCATTACCTGCGGGTCCTGCA	0.423									Mulibrey_Nanism				7	19					0.00307968	0.00778218	1	0	A	57119177	A	A	57119177	3	1	274	1	0	0	0	0	1	0	0	0	16578	768	27	3	1184	3	TRIM37	17	57119177	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	11296573	57119177	24076033	121	49801											
C17orf56	146705	broad.mit.edu	37	chr17	79204412	79204412	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagccacggccgggtgcGgaggaggatgtgctcctggg	5	6	19	11	3	0	0	0	0	0	0	1	3	1	3	3	6	4	2	3	6	0	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr17:79204412G>A	uc002jzu.1	-	11	983	c.961C>T	c.(961-963)CGC>TGC	p.R321C	C17orf56_uc002jzr.1_5'UTR|C17orf56_uc002jzs.1_Missense_Mutation_p.R237C|C17orf56_uc002jzt.1_Missense_Mutation_p.R237C|C17orf56_uc002jzv.1_Missense_Mutation_p.R169C|uc002jzw.1_RNA	NM_144679	NP_653280	Q96N21	CQ056_HUMAN	hypothetical protein LOC146705	321						integral to membrane					0	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GGCCGGGTGCGGAGGAGGATG	0.697											OREG0024811	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	25					0	0	0	0	A	79204412	A	A	79204412	3	1	274	1	0	0	0	0	1	0	0	0	1871	1116	39	1	624	1	C17orf56	17	79204412	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	22085235	79204412	1990798	122	49802											
ASXL3	80816	broad.mit.edu	37	chr18	31319985	31319986	+	Frame_Shift_Ins	INS	-	A	A																															tagcgtcctgcaaagaacagINSaaaaaaaagtgttaccttca																										TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr18:31319985_31319986insA	uc010dmg.1	+	11	2672_2673	c.2617_2618insA	c.(2617-2619)GAAfs	p.E873fs	ASXL3_uc002kxq.2_Frame_Shift_Ins_p.E580fs	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	873					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GCAAAGAACAGAAAAAAAAGTG	0.376													---	---	---								A	31319986	A	A	31319985	7	5	274	1	0	1	1	0	0	0	0	0	1070	943	33	0	2659	0	ASXL3	18	31319985	Frame_Shift_Ins	INS	-	TCGA-CX-7219-01A-11D-2012-08		31319985	46757263	123	49803											
HMHA1	23526	broad.mit.edu	37	chr19	1082981	1082981	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaggcagtggcggtggcccTggcaggtcggctgcgggagc	4	5	21	11	4	0	0	0	0	0	0	1	2	0	1	1	8	2	3	1	8	0	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:1082981T>A	uc002lqz.1	+	20	2891	c.2660T>A	c.(2659-2661)CTG>CAG	p.L887Q	HMHA1_uc010xgd.1_Missense_Mutation_p.L903Q|HMHA1_uc010xge.1_Missense_Mutation_p.L755Q|HMHA1_uc002lra.1_Missense_Mutation_p.L727Q|HMHA1_uc002lrb.1_Missense_Mutation_p.L770Q|HMHA1_uc002lrc.1_Missense_Mutation_p.L522Q|HMHA1_uc002lrd.1_5'UTR|HMHA1_uc010dsd.1_5'UTR	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	887	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGTGGCCCTGGCAGGTCGG	0.716													5	8					0	0	0	0	A	1082981	A	A	1082981	3	1	274	1	0	0	0	0	1	0	0	0	7279	1580	55	5	2738	5	HMHA1	19	1082981	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08		1082981	58046002	124	49804											
ZNF700	90592	broad.mit.edu	37	chr19	12060456	12060456	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gagaaaccctatgaatgcaaCcaatgtggtaaagccttcag	15	8	9	9	0	1	2	1	1	0	1	1	3	1	2	3	1	4	2	3	1	7	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:12060456C>G	uc002msu.2	+	4	1743	c.1617C>G	c.(1615-1617)AAC>AAG	p.N539K	ZNF700_uc010xme.1_Missense_Mutation_p.N557K|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	539	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGAATGCAACCAATGTGGTA	0.398													3	87					0	0	0	0	G	12060456	G	G	12060456	3	3	274	1	0	0	0	0	1	0	0	0	18171	506	18	4	1631	4	ZNF700	19	12060456	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	10977475	12060456	47068527	125	49805											
ZNF136	7695	broad.mit.edu	37	chr19	12296615	12296615	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcaggactcggtggcttttGaggatgtagatgtgaacttc	8	14	13	6	1	1	3	1	2	0	1	3	5	1	5	0	4	1	2	0	4	2	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:12296615G>C	uc002mti.2	+	2	119	c.19G>C	c.(19-21)GAG>CAG	p.E7Q	ZNF136_uc010xmh.1_Intron	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	7	KRAB.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						GGTGGCTTTTGAGGATGTAGA	0.478													13	59					0	0	0	0	C	12296615	C	C	12296615	3	2	274	1	0	0	0	0	1	0	0	0	17793	1291	45	2	25	2	ZNF136	19	12296615	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	236159	12296615	46832368	126	49806											
MAST3	23031	broad.mit.edu	37	chr19	18232573	18232573	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggcccctgtcgccattgtcGgtcccaacgggtgagtgtgg	4	9	15	13	4	0	1	0	1	0	0	3	1	1	1	4	4	1	0	4	4	1	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:18232573G>A	uc002nhz.3	+	3	150	c.150G>A	c.(148-150)TCG>TCA	p.S50S		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	50							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						CGCCATTGTCGGTCCCAACGG	0.687													29	83					0	0	0	0	A	18232573	A	A	18232573	2	1	274	1	0	0	0	0	0	0	0	1	9379	1103	39	1		1	MAST3	19	18232573	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	5935958	18232573	40896410	127	49807											
PDCD2L	84306	broad.mit.edu	37	chr19	34895682	34895682	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtctgctgcacgtgttcgcGtgcgcctgccccggctgtag	2	10	14	15	6	1	0	0	0	1	0	2	0	1	0	3	1	4	5	3	1	1	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:34895682G>T	uc002nvj.2	+	2	270	c.237G>T	c.(235-237)GCG>GCT	p.A79A		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	79						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			ACGTGTTCGCGTGCGCCTGCC	0.716													5	11					0.00116845	0.00300661	1	0	T	34895682	T	T	34895682	2	4	274	1	0	0	0	0	0	0	0	1	11674	1132	40	3		3	PDCD2L	19	34895682	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	16663109	34895682	24233301	128	49808											
PSMC4	5704	broad.mit.edu	37	chr19	40478119	40478119	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttcctgggccctgagcctGaggacctggaggacctgtac	6	8	13	14	0	0	2	0	2	0	0	1	5	1	5	6	4	2	1	6	4	1	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:40478119G>C	uc002omq.2	+	2	140	c.103G>C	c.(103-105)GAG>CAG	p.E35Q	PSMC4_uc002omr.2_Missense_Mutation_p.E35Q	NM_006503	NP_006494	P43686	PRS6B_HUMAN	proteasome 26S ATPase subunit 4 isoform 1	35					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			ovary(1)	1	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CCCTGAGCCTGAGGACCTGGA	0.582													24	82					0	0	0	0	C	40478119	C	C	40478119	3	2	274	1	0	0	0	0	1	0	0	0	12751	1291	45	2	109	2	PSMC4	19	40478119	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	5582437	40478119	18650864	129	49809											
FAM83E	54854	broad.mit.edu	37	chr19	49104463	49104463	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcatccccaccgaaccgcCttcgggctggggacagatag	9	6	12	14	3	0	1	0	0	0	1	2	3	1	2	5	3	2	2	5	3	3	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:49104463C>G	uc002pjn.2	-	5	1405	c.1340G>C	c.(1339-1341)AGG>ACG	p.R447T		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	447										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		ACCGAACCGCCTTCGGGCTGG	0.701													11	30					0	0	0	0	G	49104463	G	G	49104463	3	3	274	1	0	0	0	0	1	0	0	0	5669	681	24	4	100	4	FAM83E	19	49104463	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	8626344	49104463	10024520	130	49810											
ZNF845	91664	broad.mit.edu	37	chr19	53855570	53855570	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgtagacttcatactggaGagaaaccttaccagtgtaat	14	12	8	7	0	1	2	1	0	0	2	1	4	1	3	2	1	3	2	2	1	5	6			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:53855570G>A	uc010ydv.1	+	4	1759	c.1642G>A	c.(1642-1644)GAG>AAG	p.E548K	ZNF845_uc010ydw.1_Missense_Mutation_p.E548K	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	548					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATACTGGAGAGAAACCTTA	0.413													6	75					0	0	0	0	A	53855570	A	A	53855570	3	1	274	1	0	0	0	0	1	0	0	0	18258	943	33	2	1652	2	ZNF845	19	53855570	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	4751107	53855570	5273413	131	49811											
ZNF132	7691	broad.mit.edu	37	chr19	58944808	58944808	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctggtgccgaacaagtgtaGatctttcactaaaggctttt	10	14	9	8	1	3	1	1	0	2	1	3	2	3	1	1	2	2	2	1	2	5	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr19:58944808G>C	uc002qst.3	-	3	2404	c.2003C>G	c.(2002-2004)TCT>TGT	p.S668C		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	668	C2H2-type 17.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		AACAAGTGTAGATCTTTCACT	0.468													7	64					0	0	0	0	C	58944808	C	C	58944808	3	2	274	1	0	0	0	0	1	0	0	0	17789	942	33	2	121	2	ZNF132	19	58944808	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	5089238	58944808	184175	132	49812											
PLCB1	23236	broad.mit.edu	37	chr20	8713951	8713951	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtggctacagattgaagcCagagttcatgaggaggcctg	11	8	15	7	0	1	4	1	2	0	2	1	6	1	5	2	3	2	2	2	3	2	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:8713951C>A	uc002wnb.2	+	19	1958	c.1955C>A	c.(1954-1956)CCA>CAA	p.P652Q	PLCB1_uc010zrb.1_Missense_Mutation_p.P551Q|PLCB1_uc002wna.2_Missense_Mutation_p.P652Q|PLCB1_uc002wnc.1_Missense_Mutation_p.P551Q|PLCB1_uc002wnd.1_Missense_Mutation_p.P229Q	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	652	PI-PLC Y-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AGATTGAAGCCAGAGTTCATG	0.423													15	67					2.31682e-05	6.14905e-05	1	0	A	8713951	A	A	8713951	3	1	274	1	0	0	0	0	1	0	0	0	12082	594	21	4	2029	4	PLCB1	20	8713951	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08		8713951	54311569	133	49813											
ACSS1	84532	broad.mit.edu	37	chr20	25038539	25038567	+	Frame_Shift_Del	DEL	CGGGCTGCCTGTGCACTCAGCGCGGGATA	-	-																															cccagaaggcggccggctccCgggctgcctgtgcactcagc																								rs73348757	by1000genomes	TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:25038539_25038567delCGGGCTGCCTGTGCACTCAGCGCGGGATA	uc002wub.2	-	1	1050_1078	c.172_200delTATCCCGCGCTGAGTGCACAGGCAGCCCG	c.(172-201)TATCCCGCGCTGAGTGCACAGGCAGCCCGGfs	p.Y58fs	ACSS1_uc002wuc.2_Frame_Shift_Del_p.Y58fs|ACSS1_uc010gdc.2_Frame_Shift_Del_p.Y58fs	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	58_67					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GGCCGGCTCCCGGGCTGCCTGTGCACTCAGCGCGGGATACGAGCCTGGC	0.734													---	---	---								-	25038567	-	-	25038539	7	5	274	1	0	1	0	1	0	0	0	0	188	652	23	0	1925	0	ACSS1	20	25038539	Frame_Shift_Del	DEL	CGGGCTGCCTGTGCACTCAGCGCGGGATA	TCGA-CX-7219-01A-11D-2012-08	16324588	25038539	37986981	134	49814											
NINL	22981	broad.mit.edu	37	chr20	25457633	25457633	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcgtggcaggggtccctgcGgcggctcctccagctccaag	4	6	15	16	4	0	0	0	0	0	0	4	0	4	0	4	5	2	3	4	5	1	0			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:25457633G>A	uc002wux.1	-	17	2368	c.2294C>T	c.(2293-2295)CCG>CTG	p.P765L	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	765					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GGGTCCCTGCGGCGGCTCCTC	0.692													12	7					0	0	0	0	A	25457633	A	A	25457633	3	1	274	1	0	0	0	0	1	0	0	0	10474	1116	39	1	1886	1	NINL	20	25457633	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	419094	25457633	37567887	135	49815											
DIDO1	11083	broad.mit.edu	37	chr20	61512690	61512690	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcgggcttgtctgcagactGctgctcttgctggaacagct	5	11	14	11	1	2	1	0	0	2	1	2	2	2	2	0	3	6	6	0	3	1	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:61512690G>A	uc002ydr.1	-	16	4882	c.4618C>T	c.(4618-4620)CAG>TAG	p.Q1540*	DIDO1_uc002yds.1_Nonsense_Mutation_p.Q1540*	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1540					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TCTGCAGACTGCTGCTCTTGC	0.667													45	54					0	0	0	0	A	61512690	A	A	61512690	4	1	274	1	0	0	0	0	0	1	0	0	4544	1328	46	4	2108	4	DIDO1	20	61512690	Nonsense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	36055057	61512690	1512830	136	49816											
DIDO1	11083	broad.mit.edu	37	chr20	61542922	61542922	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttgctggtgggtttgatggCcttaggtgcctcctcattgc	3	16	13	9	0	1	1	1	1	0	0	2	1	2	1	3	4	3	2	3	4	1	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:61542922C>T	uc002ydr.1	-	3	307	c.43G>A	c.(43-45)GCC>ACC	p.A15T	DIDO1_uc002yds.1_Missense_Mutation_p.A15T|DIDO1_uc002ydt.1_Missense_Mutation_p.A15T|DIDO1_uc002ydu.1_Missense_Mutation_p.A15T|DIDO1_uc002ydv.1_Missense_Mutation_p.A15T|DIDO1_uc002ydw.1_Missense_Mutation_p.A15T|DIDO1_uc002ydx.1_Missense_Mutation_p.A15T|DIDO1_uc011aao.1_Missense_Mutation_p.A15T	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	15					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GGTTTGATGGCCTTAGGTGCC	0.542													12	13					0	0	0	0	T	61542922	T	T	61542922	3	4	274	1	0	0	0	0	1	0	0	0	4544	739	26	4	6865	4	DIDO1	20	61542922	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	30232	61542922	1482598	137	49817											
ZNF512B	57473	broad.mit.edu	37	chr20	62597655	62597655	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgactgtcactggcttGgtgaccggcacgggtttcgt	4	12	14	11	3	1	2	1	2	0	0	2	2	1	2	1	4	1	4	1	4	0	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr20:62597655G>T	uc002yhl.1	-	5	927	c.873C>A	c.(871-873)ACC>ACA	p.T291T		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TCACTGGCTTGGTGACCGGCA	0.557													8	214					0.000219431	0.000575156	1	0	T	62597655	T	T	62597655	2	4	274	1	0	0	0	0	0	0	0	1	18024	1335	47	4		4	ZNF512B	20	62597655	Silent	SNP	G	TCGA-CX-7219-01A-11D-2012-08	1054733	62597655	427865	138	49818											
U2AF1	7307	broad.mit.edu	37	chr21	44524445	44524445	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggctaaacgtcggtttatTgtgcaaccgagagcacctgt	9	11	11	10	3	0	1	0	0	0	1	1	2	0	1	2	2	4	4	2	2	4	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr21:44524445T>G	uc002zda.1	-	2	196	c.112A>C	c.(112-114)AAT>CAT	p.N38H	U2AF1_uc002zcy.1_5'UTR|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Missense_Mutation_p.N38H|U2AF1_uc010gpi.1_Missense_Mutation_p.N38H|U2AF1_uc002zdc.1_Missense_Mutation_p.N38H	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	38	C3H1-type 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						GTCGGTTTATTGTGCAACCGA	0.343													6	16					0	0	0	0	G	44524445	G	G	44524445	3	3	274	1	0	0	0	0	1	0	0	0	16889	1812	63	5	709	5	U2AF1	21	44524445	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08		44524445	3605450	139	49819											
EP300	2033	broad.mit.edu	37	chr22	41564727	41564727	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accatctcaattgtataggtTtgtggacagtggagagatgg	11	12	13	5	0	1	1	1	0	1	1	2	4	1	3	1	4	0	2	1	4	3	4			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chr22:41564727T>G	uc003azl.3	+	25	4423	c.4028T>G	c.(4027-4029)TTT>TGT	p.F1343C		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1343					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TTGTATAGGTTTGTGGACAGT	0.443			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				17	46					0	0	0	0	G	41564727	G	G	41564727	3	3	274	1	0	0	0	0	1	0	0	0	5172	1841	64	5	4126	5	EP300	22	41564727	Missense_Mutation	SNP	T	TCGA-CX-7219-01A-11D-2012-08		41564727	9739839	140	49820											
ZCCHC18	644353	broad.mit.edu	37	chrX	103359010	103359010	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actggctgatccaagtcaatGaggtcctgccagattggagt	10	10	12	9	0	1	3	1	2	0	1	3	4	3	4	3	3	1	1	3	3	2	1			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chrX:103359010G>C	uc011msh.1	+	3	1524	c.208G>C	c.(208-210)GAG>CAG	p.E70Q	MCART6_uc004elu.2_Intron|ZCCHC18_uc011msg.1_Intron	NM_001143978	NP_001137450	P0CG32	ZCC18_HUMAN	zinc finger, CCHC domain containing 18	70							nucleic acid binding|zinc ion binding				0						CCAAGTCAATGAGGTCCTGCC	0.502													7	8					0	0	0	0	C	103359010	C	C	103359010	3	2	274	1	0	0	0	0	1	0	0	0	17653	1291	45	2	210	2	ZCCHC18	23	103359010	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08		103359010	51911550	141	49821											
PSMD10	5716	broad.mit.edu	37	chrX	107331314	107331314	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagaagccgcaatatgaaGaggagaccaacctgcctata	16	5	10	10	1	0	4	0	1	0	3	0	5	0	4	4	1	4	2	4	1	7	3			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chrX:107331314G>A	uc004enp.1	-	3	327	c.229C>T	c.(229-231)CTT>TTT	p.L77F	PSMD10_uc004enq.1_Missense_Mutation_p.L77F|PSMD10_uc010nph.1_Intron	NM_002814	NP_002805	O75832	PSD10_HUMAN	proteasome 26S non-ATPase subunit 10 isoform 1	77	Interaction with RELA.|ANK 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			ovary(1)	1						GCAATATGAAGAGGAGACCAA	0.453													16	27					0	0	0	0	A	107331314	A	A	107331314	3	1	274	1	0	0	0	0	1	0	0	0	12755	942	33	2	463	2	PSMD10	23	107331314	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	3972304	107331314	47939246	142	49822											
CXorf56	63932	broad.mit.edu	37	chrX	118673707	118673707	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggttatttgaactggttgtCaatcaaggtccccttcattt	8	17	8	8	0	3	1	3	1	0	0	4	1	4	1	2	3	1	2	2	3	4	5			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chrX:118673707C>G	uc004erk.1	-	7	698	c.652G>C	c.(652-654)GAC>CAC	p.D218H	uc004eri.2_5'Flank|CXorf56_uc004erj.1_Missense_Mutation_p.D169H|CXorf56_uc011mtu.1_Missense_Mutation_p.D204H	NM_022101	NP_071384	Q9H5V9	CX056_HUMAN	hypothetical protein LOC63932	218	Potential.						protein binding				0						AACTGGTTGTCAATCAAGGTC	0.373													9	11					0	0	0	0	G	118673707	G	G	118673707	3	3	274	1	0	0	0	0	1	0	0	0	4129	826	29	2	20	2	CXorf56	23	118673707	Missense_Mutation	SNP	C	TCGA-CX-7219-01A-11D-2012-08	11342393	118673707	36596853	143	49823											
CNGA2	1260	broad.mit.edu	37	chrX	150912370	150912370	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggctggcctgctggtagaGctggtactgaaactccgtcc	7	9	14	11	1	0	2	0	1	0	1	2	3	2	2	3	4	4	5	3	4	3	2			TCGA-CX-7219-01A-11D-2012-08	TCGA-CX-7219-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	83f92af6-60ab-402e-8990-e1060ca3cc4c	36b8d80c-bb4c-404e-92fb-5ad87b3b5272	g.chrX:150912370G>C	uc004fey.1	+	7	1619	c.1395G>C	c.(1393-1395)GAG>GAC	p.E465D		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	465	Helical; Name=H6; (Potential).|cAMP (By similarity).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGCTGGTAGAGCTGGTACTGA	0.408													19	30					0	0	0	0	C	150912370	C	C	150912370	3	2	274	1	0	0	0	0	1	0	0	0	3612	962	34	4	1417	4	CNGA2	23	150912370	Missense_Mutation	SNP	G	TCGA-CX-7219-01A-11D-2012-08	32238663	150912370	4358190	144	49824											
TTLL10	254173	broad.mit.edu	37	chr1	1117129	1117129	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgggctgcaggctggaaaAggacgcagcagcgcccgccc	8	3	15	15	3	0	0	0	0	0	0	0	2	0	2	3	4	3	5	3	4	2	0			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:1117129A>T	uc001acy.2	+	9	915	c.764A>T	c.(763-765)AAG>ATG	p.K255M	uc001acx.1_5'Flank|TTLL10_uc010nyg.1_Missense_Mutation_p.K255M|TTLL10_uc001acz.1_Missense_Mutation_p.K182M	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	255	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGGCTGGAAAAGGACGCAGCA	0.672													3	12					0	0	0	0	T	1117129	T	T	1117129	3	4	275	1	0	0	0	0	1	0	0	0	16791	72	3	5	786	5	TTLL10	1	1117129	Missense_Mutation	SNP	A	TCGA-D6-6515-01A-21D-1870-08		1117129	248133492	1	49825											
JAK1	3716	broad.mit.edu	37	chr1	65303626	65303627	+	Missense_Mutation	DNP	GC	AA	AA																															ttcagttaccaaaacacaggGctgtcccggtcatccttgac																										TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:65303626_65303627GC>AA	uc001dbu.1	-	22	3377_3378	c.3128_3129GC>TT	c.(3127-3129)AGC>ATT	p.S1043I	JAK1_uc009wam.1_Missense_Mutation_p.S1031I|JAK1_uc009wal.1_Missense_Mutation_p.S220I	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	1043	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		AAAACACAGGGCTGTCCCGGTC	0.401			Mis		ALL								3	52					0	0	0	0	AA	65303627	AA	AA	65303626	3	1	275	1	0	0	0	0	1	0	0	0	7976	1194	42	4	351	4	JAK1	1	65303626	Missense_Mutation	DNP	GC	TCGA-D6-6515-01A-21D-1870-08	64186497	65303626	183946995	2	49826											
JAK1	3716	broad.mit.edu	37	chr1	65306941	65306941	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacttacctctcccaagtcaCggatcctctttaggaagcgc	10	10	7	14	2	3	0	1	0	2	0	5	2	4	2	3	2	3	0	3	2	5	3			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:65306941C>T	uc001dbu.1	-	19	2885	c.2636G>A	c.(2635-2637)CGT>CAT	p.R879H	JAK1_uc009wam.1_Missense_Mutation_p.R867H|JAK1_uc009wal.1_Missense_Mutation_p.R56H	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	879	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity	p.R879S(1)|p.R879C(1)|p.R879H(1)		haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TCCCAAGTCACGGATCCTCTT	0.493			Mis		ALL								9	70					0	0	0	0	T	65306941	T	T	65306941	3	4	275	1	0	0	0	0	1	0	0	0	7976	536	19	1	856	1	JAK1	1	65306941	Missense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08	3315	65306941	183943680	3	49827											
MSH4	4438	broad.mit.edu	37	chr1	76365359	76365359	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caattgtcttggatgccaagGaaatcacaactcaaattacg	15	10	7	9	1	3	0	2	0	1	0	3	2	3	2	1	2	3	0	1	2	6	3			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:76365359G>A	uc001dhd.1	+	19	2628	c.2587G>A	c.(2587-2589)GAA>AAA	p.E863K		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	863					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						GGATGCCAAGGAAATCACAAC	0.294								MMR					8	66					0	0	0	0	A	76365359	A	A	76365359	3	1	275	1	0	0	0	0	1	0	0	0	9925	1175	41	2	2661	2	MSH4	1	76365359	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	11058418	76365359	172885262	4	49828											
MTMR11	10903	broad.mit.edu	37	chr1	149905361	149905361	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catctgcaaggctgggcagcTcatccatagtgtctaccagg	9	9	11	12	0	3	0	1	0	2	0	4	0	4	0	2	3	3	4	2	3	3	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:149905361T>C	uc001etl.3	-	10	1174	c.923A>G	c.(922-924)GAG>GGG	p.E308G	MTMR11_uc001etm.1_Missense_Mutation_p.E236G|MTMR11_uc010pbm.1_Missense_Mutation_p.E280G|MTMR11_uc010pbn.1_Missense_Mutation_p.E150G	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	308	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GCTGGGCAGCTCATCCATAGT	0.567													3	79					0	0	0	0	C	149905361	C	C	149905361	3	2	275	1	0	0	0	0	1	0	0	0	9993	1551	54	5	1277	5	MTMR11	1	149905361	Missense_Mutation	SNP	T	TCGA-D6-6515-01A-21D-1870-08	73540002	149905361	99345260	5	49829											
ANP32E	81611	broad.mit.edu	37	chr1	150202922	150202922	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaccagagcttctactgtaCtgagatcttttattttgttt	8	20	6	7	0	2	2	0	1	2	2	2	3	2	2	1	0	4	3	1	0	4	9			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:150202922C>G	uc001etw.2	-	3	681	c.311G>C	c.(310-312)AGT>ACT	p.S104T	ANP32E_uc010pbu.1_Missense_Mutation_p.S56T|ANP32E_uc010pbv.1_Intron|ANP32E_uc001etv.3_Missense_Mutation_p.S104T|ANP32E_uc010pbw.1_Missense_Mutation_p.S104T	NM_030920	NP_112182	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	104	LRR 4.					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity				0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTCTACTGTACTGAGATCTTT	0.343													7	57					0	0	0	0	G	150202922	G	G	150202922	3	3	275	1	0	0	0	0	1	0	0	0	709	565	20	4	515	4	ANP32E	1	150202922	Missense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08	297561	150202922	99047699	6	49830											
DDX1	1653	broad.mit.edu	37	chr2	15770222	15770222	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagttacctacggtcagaaaAgggctgctggtggtaagctt	11	10	13	7	1	1	1	1	0	0	1	1	1	1	1	1	4	4	5	1	4	6	4			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr2:15770222A>G	uc002rce.2	+	25	2368	c.2080A>G	c.(2080-2082)AGG>GGG	p.R694G		NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	694	Necessary for interaction with HNRNPK.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		CGGTCAGAAAAGGGCTGCTGG	0.373													3	118					0	0	0	0	G	15770222	G	G	15770222	3	3	275	1	0	0	0	0	1	0	0	0	4358	63	3	5	2178	5	DDX1	2	15770222	Missense_Mutation	SNP	A	TCGA-D6-6515-01A-21D-1870-08		15770222	227429151	7	49831											
APOB	338	broad.mit.edu	37	chr2	21233487	21233487	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacaactataatggtttgtcGattcctctcaaaatattctt	12	17	4	8	1	2	0	1	0	2	0	5	1	3	0	1	1	2	1	1	1	7	8	rs121918386		TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr2:21233487G>A	uc002red.2	-	26	6381	c.6253C>T	c.(6253-6255)CGA>TGA	p.R2085*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2085	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGGTTTGTCGATTCCTCTCA	0.343													6	57					0	0	0	0	A	21233487	A	A	21233487	4	1	275	1	0	0	0	0	0	1	0	0	785	1066	37	1	7454	1	APOB	2	21233487	Nonsense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	5463265	21233487	221965886	8	49832											
TCF7L1	83439	broad.mit.edu	37	chr2	85536379	85536379	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctggctctccactctgccGccttcctgtcggctaaggct	4	11	10	16	2	2	0	0	0	2	0	5	0	3	0	4	3	2	4	4	3	1	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr2:85536379G>A	uc002soy.2	+	12	1635	c.1561G>A	c.(1561-1563)GCC>ACC	p.A521T		NM_031283	NP_112573	Q9HCS4	TF7L1_HUMAN	HMG-box transcription factor TCF-3	521					chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)|central_nervous_system(1)	3						CCACTCTGCCGCCTTCCTGTC	0.687													6	26					0	0	0	0	A	85536379	A	A	85536379	3	1	275	1	0	0	0	0	1	0	0	0	15763	1087	38	1	1607	1	TCF7L1	2	85536379	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	64302892	85536379	157662994	9	49833											
STAT1	6772	broad.mit.edu	37	chr2	191843715	191843715	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcgctccttgctgatgaaGcccatgatgcacctggatat	8	12	9	12	1	1	3	0	3	1	0	3	4	2	4	3	1	3	3	3	1	2	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr2:191843715G>A	uc002usj.2	-	21	2128	c.1740C>T	c.(1738-1740)GGC>GGT	p.G580G	STAT1_uc010fse.1_Silent_p.G580G|STAT1_uc002usk.2_Silent_p.G580G|STAT1_uc002usl.2_Silent_p.G582G	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	580	SH2.				activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TGCTGATGAAGCCCATGATGC	0.522													3	21					0	0	0	0	A	191843715	A	A	191843715	2	1	275	1	0	0	0	0	0	0	0	1	15330	958	34	4		4	STAT1	2	191843715	Silent	SNP	G	TCGA-D6-6515-01A-21D-1870-08	106307336	191843715	51355658	10	49834											
PGAP1	80055	broad.mit.edu	37	chr2	197763049	197763049	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtattaacttaccacacaatGgagaggtggtctgttgagac	12	11	11	7	0	1	2	0	1	1	2	1	4	1	2	1	3	2	2	1	3	4	4			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr2:197763049G>A	uc002utw.2	-	6	966	c.852C>T	c.(850-852)TCC>TCT	p.S284S	PGAP1_uc002utx.2_Silent_p.S110S|PGAP1_uc002uty.1_Silent_p.S284S|PGAP1_uc010zgv.1_RNA|PGAP1_uc010fsj.2_Silent_p.S110S	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	284	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						ACCACACAATGGAGAGGTGGT	0.343													11	67					0	0	0	0	A	197763049	A	A	197763049	2	1	275	1	0	0	0	0	0	0	0	1	11832	1335	47	4		4	PGAP1	2	197763049	Silent	SNP	G	TCGA-D6-6515-01A-21D-1870-08	5919334	197763049	45436324	11	49835											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	57					0	0	0	0	A	178936091	A	A	178936091	3	1	275	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08		178936091	19086339	12	49836											
C4orf37	285555	broad.mit.edu	37	chr4	98893492	98893492	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaaccgagaagaaagtccgaGgaacagaagaaccaaatgca	20	2	11	8	2	0	4	0	0	0	4	1	8	1	5	3	1	4	1	3	1	7	0			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr4:98893492G>A	uc003htt.1	-	7	962	c.872C>T	c.(871-873)CCT>CTT	p.P291L		NM_174952	NP_777612	Q8N412	CD037_HUMAN	hypothetical protein LOC285555	291											0				OV - Ovarian serous cystadenocarcinoma(123;2.27e-08)		GAAAGTCCGAGGAACAGAAGA	0.358													6	120					0	0	0	0	A	98893492	A	A	98893492	3	1	275	1	0	0	0	0	1	0	0	0	2277	1000	35	4	527	4	C4orf37	4	98893492	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08		98893492	92260784	13	49837											
METTL14	57721	broad.mit.edu	37	chr4	119621745	119621745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagattgcagcacctcgatCatttatttttctctggtgtg	7	17	9	8	1	2	1	1	1	1	1	4	3	2	1	1	1	2	2	1	1	1	5			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr4:119621745C>T	uc003icf.2	+	8	802	c.686C>T	c.(685-687)TCA>TTA	p.S229L	METTL14_uc003icg.2_Missense_Mutation_p.S191L	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	229						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						GCACCTCGATCATTTATTTTT	0.338													12	81					0	0	0	0	T	119621745	T	T	119621745	3	4	275	1	0	0	0	0	1	0	0	0	9551	838	29	2	716	2	METTL14	4	119621745	Missense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08	20728253	119621745	71532531	14	49838											
FAT4	79633	broad.mit.edu	37	chr4	126372350	126372350	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgaggtcactgtaaatgtCaccgtgcttgatgcaaatga	12	11	11	7	1	2	3	2	3	0	0	2	4	2	3	1	1	2	3	1	1	3	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr4:126372350C>T	uc003ifj.3	+	9	10179	c.10179C>T	c.(10177-10179)GTC>GTT	p.V3393V	FAT4_uc011cgp.1_Silent_p.V1691V|FAT4_uc003ifi.1_Silent_p.V871V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3393	Cadherin 32.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGTAAATGTCACCGTGCTTG	0.428													19	161					0	0	0	0	T	126372350	T	T	126372350	2	4	275	1	0	0	0	0	0	0	0	1	5724	813	29	2		2	FAT4	4	126372350	Silent	SNP	C	TCGA-D6-6515-01A-21D-1870-08	6750605	126372350	64781926	15	49839											
MAP9	79884	broad.mit.edu	37	chr4	156277012	156277012	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccttttagaactagatttCttcaaaaactcagaggtcat	13	14	5	9	0	4	3	3	0	1	3	5	3	5	3	1	1	2	0	1	1	5	5			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr4:156277012C>T	uc003ios.2	-	9	1410	c.1146G>A	c.(1144-1146)AAG>AAA	p.K382K	MAP9_uc011cin.1_Silent_p.K357K|MAP9_uc010iqa.1_Intron|MAP9_uc003iot.1_Silent_p.K381K	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	382					cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		AACTAGATTTCTTCAAAAACT	0.348													4	38					0	0	0	0	T	156277012	T	T	156277012	2	4	275	1	0	0	0	0	0	0	0	1	9323	912	32	2		2	MAP9	4	156277012	Silent	SNP	C	TCGA-D6-6515-01A-21D-1870-08	29904662	156277012	34877264	16	49840											
ASB5	140458	broad.mit.edu	37	chr4	177146412	177146412	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aaactatatgtaatatattaCctgtgataataatgttctca	16	16	4	5	0	1	1	1	1	1	0	2	1	1	1	1	0	2	2	1	0	9	9			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr4:177146412C>T	uc003iuq.1	-	2	292	c.276_splice	c.e2+1	p.Q92_splice	ASB5_uc003iup.1_Splice_Site_p.Q39_splice	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein						intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TAATATATTACCTGTGATAAT	0.353													5	47					0	0	0	0	T	177146412	T	T	177146412	5	4	275	1	0	0	0	0	0	0	1	0	1028	521	18	4	736	4	ASB5	4	177146412	Splice_Site	SNP	C	TCGA-D6-6515-01A-21D-1870-08	20869400	177146412	14007864	17	49841											
C6	729	broad.mit.edu	37	chr5	41199881	41199881	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atacattaccactgtcacagCgaaatttattcttgcagtca	13	13	5	10	1	3	0	2	0	1	0	3	1	3	0	1	0	4	1	1	0	4	6			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr5:41199881C>T	uc003jmk.2	-	4	644	c.434G>A	c.(433-435)CGC>CAC	p.R145H	C6_uc003jml.1_Missense_Mutation_p.R145H	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	145	LDL-receptor class A.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ACTGTCACAGCGAAATTTATT	0.413													15	105					0	0	0	0	T	41199881	T	T	41199881	3	4	275	1	0	0	0	0	1	0	0	0	2325	768	27	1	2430	1	C6	5	41199881	Missense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08		41199881	139715379	18	49842											
CHD1	1105	broad.mit.edu	37	chr5	98218909	98218909	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctaaattaatccctagaccTccagctcttgtggacagcaa	12	10	7	12	0	1	1	0	0	1	1	3	2	3	2	3	1	2	3	3	1	5	4			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr5:98218909T>C	uc003knf.2	-	18	2749	c.2601A>G	c.(2599-2601)GGA>GGG	p.G867G		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	867	Helicase C-terminal.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TCCCTAGACCTCCAGCTCTTG	0.373													3	43					0	0	0	0	C	98218909	C	C	98218909	2	2	275	1	0	0	0	0	0	0	0	1	3338	1538	54	5		5	CHD1	5	98218909	Silent	SNP	T	TCGA-D6-6515-01A-21D-1870-08	57019028	98218909	82696351	19	49843											
TMED7-TICAM2	100302736	broad.mit.edu	37	chr5	114916440	114916440	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	attgttcaggggccgcatggGtataacagagttgtatttat	10	14	12	5	1	1	1	1	0	0	1	1	1	1	1	1	3	1	5	1	3	4	8			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr5:114916440G>A	uc003krd.2	-	4	1520	c.514C>T	c.(514-516)CCC>TCC	p.P172S	TMED7-TICAM2_uc003kre.2_Missense_Mutation_p.P341S|TICAM2_uc003krc.2_Missense_Mutation_p.P172S	NM_021649	NP_067681	Q86XR7	TCAM2_HUMAN	toll-like receptor adaptor molecule 2	172	TIR.				I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	Golgi apparatus|intrinsic to membrane|plasma membrane	protein binding|transmembrane receptor activity				0						GGCCGCATGGGTATAACAGAG	0.443													6	84					0	0	0	0	A	114916440	A	A	114916440	3	1	275	1	0	0	0	0	1	0	0	0	16076	1261	44	4		4	TMED7-TICAM2	5	114916440	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	16697531	114916440	65998820	20	49844											
DIAPH1	1729	broad.mit.edu	37	chr5	140908785	140908785	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaggtcatcatattcatccTtcagttcagaaagcattttt	11	15	5	10	0	5	1	5	0	0	1	6	1	6	1	2	1	1	2	2	1	2	6			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr5:140908785T>C	uc003llb.3	-	22	2873	c.2732A>G	c.(2731-2733)AAG>AGG	p.K911R	DIAPH1_uc011dbd.1_5'Flank|DIAPH1_uc003llc.3_Missense_Mutation_p.K902R|DIAPH1_uc010jgc.1_Missense_Mutation_p.K347R	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	911	FH2.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATATTCATCCTTCAGTTCAGA	0.498													9	73					0	0	0	0	C	140908785	C	C	140908785	3	2	275	1	0	0	0	0	1	0	0	0	4540	1609	56	5	1118	5	DIAPH1	5	140908785	Missense_Mutation	SNP	T	TCGA-D6-6515-01A-21D-1870-08	25992345	140908785	40006475	21	49845											
N4BP3	23138	broad.mit.edu	37	chr5	177548577	177548577	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatcttcagtctgaagacaCaacttcggggcagccgggca	11	7	12	11	2	3	3	1	1	2	2	4	3	3	3	1	3	2	2	1	3	2	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr5:177548577C>T	uc003mik.1	+	5	1457	c.1210C>T	c.(1210-1212)CAA>TAA	p.Q404*	N4BP3_uc003mil.1_Nonsense_Mutation_p.Q73*	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	404	Potential.					cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTGAAGACACAACTTCGGGG	0.647													13	85					0	0	0	0	T	177548577	T	T	177548577	4	4	275	1	0	0	0	0	0	1	0	0	10166	479	17	4	1224	4	N4BP3	5	177548577	Nonsense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08	36639792	177548577	3366683	22	49846											
MEP1A	4224	broad.mit.edu	37	chr6	46787388	46787388	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggattttaccacgagcagtCaaggacggaccgggatgatt	11	8	14	8	3	1	1	1	1	0	0	1	6	1	5	2	4	2	1	2	4	2	3			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr6:46787388C>G	uc010jzh.1	+	7	545	c.503C>G	c.(502-504)TCA>TGA	p.S168*	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Nonsense_Mutation_p.S196*|MEP1A_uc011dwi.1_Nonsense_Mutation_p.S68*	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	168	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			CACGAGCAGTCAAGGACGGAC	0.478													5	227					0	0	0	0	G	46787388	G	G	46787388	4	3	275	1	0	0	0	0	0	1	0	0	9528	838	29	2	529	2	MEP1A	6	46787388	Nonsense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08		46787388	124327679	23	49847											
PION	54103	broad.mit.edu	37	chr7	77006706	77006706	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatggccagaatttttaatcAcctaaaaatgcaaaaaaaaa	21	9	5	6	0	1	1	1	0	0	1	1	2	1	1	2	1	1	1	2	1	9	4			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr7:77006706A>C	uc003ugf.2	-	9	657	c.578T>G	c.(577-579)GTG>GGG	p.V193G	PION_uc003ugg.1_5'UTR	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	193					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						ATTTTTAATCACCTAAAAATG	0.308													9	64					0	0	0	0	C	77006706	C	C	77006706	3	2	275	1	0	0	0	0	1	0	0	0	11989	173	6	5	2078	5	PION	7	77006706	Missense_Mutation	SNP	A	TCGA-D6-6515-01A-21D-1870-08		77006706	82131957	24	49848											
SH2D4A	63898	broad.mit.edu	37	chr8	19190591	19190591	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattattgctgagagggccCggctgaaagcagaacaggag	14	6	14	7	1	0	3	0	2	0	2	0	5	0	4	1	3	3	3	1	3	4	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr8:19190591C>T	uc003wzb.2	+	3	643	c.307C>T	c.(307-309)CGG>TGG	p.R103W	SH2D4A_uc011kym.1_Missense_Mutation_p.R58W|SH2D4A_uc003wzc.2_Missense_Mutation_p.R103W	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	103						cytoplasm|nucleus	protein binding				0				Colorectal(111;0.0732)		TGAGAGGGCCCGGCTGAAAGC	0.463													8	68					0	0	0	0	T	19190591	T	T	19190591	3	4	275	1	0	0	0	0	1	0	0	0	14300	643	23	1	363	1	SH2D4A	8	19190591	Missense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08		19190591	127173431	25	49849											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			3	14					0	0	0	0	A	21971120	A	A	21971120	4	1	275	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08		21971120	119242311	26	49850											
LRP5	4041	broad.mit.edu	37	chr11	68133078	68133078	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacaatggcggctgctcccAcctgtgcctgctgtccccaa	6	8	11	16	1	0	0	0	0	0	0	2	1	2	1	5	3	3	3	5	3	2	0			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr11:68133078A>C	uc001ont.2	+	5	998	c.923A>C	c.(922-924)CAC>CCC	p.H308P	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	308	EGF-like 1.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GGCTGCTCCCACCTGTGCCTG	0.587													8	104					0	0	0	0	C	68133078	C	C	68133078	3	2	275	1	0	0	0	0	1	0	0	0	9010	159	6	5	941	5	LRP5	11	68133078	Missense_Mutation	SNP	A	TCGA-D6-6515-01A-21D-1870-08		68133078	66873438	27	49851											
CD163	9332	broad.mit.edu	37	chr12	7636017	7636017	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acactcactatggccccagcGtctggcaggacaatcccaca	11	6	8	16	1	2	0	1	0	1	0	3	1	3	1	3	3	1	1	3	3	2	1			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr12:7636017G>A	uc001qsz.3	-	12	3162	c.3034C>T	c.(3034-3036)CGC>TGC	p.R1012C	CD163_uc001qta.3_Missense_Mutation_p.R1012C|CD163_uc009zfw.2_Missense_Mutation_p.R1045C	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1012	SRCR 9.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TGGCCCCAGCGTCTGGCAGGA	0.512													7	50					0	0	0	0	A	7636017	A	A	7636017	3	1	275	1	0	0	0	0	1	0	0	0	2982	1145	40	1	456	1	CD163	12	7636017	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08		7636017	126215878	28	49852											
KRT78	196374	broad.mit.edu	37	chr12	53233611	53233611	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacatccagggaaagcttcGtgctcgtcagctcctggtac	8	9	10	14	2	1	0	1	0	0	0	5	1	3	1	3	2	4	4	3	2	2	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr12:53233611G>A	uc001sbc.1	-	7	1269	c.1205C>T	c.(1204-1206)ACG>ATG	p.T402M		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	402	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						GGAAAGCTTCGTGCTCGTCAG	0.612													9	59					0	0	0	0	A	53233611	A	A	53233611	3	1	275	1	0	0	0	0	1	0	0	0	8530	1145	40	1	369	1	KRT78	12	53233611	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	45597594	53233611	80618284	29	49853											
CSNK1A1L	122011	broad.mit.edu	37	chr13	37679304	37679304	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtgatgcccagataaacGtctccaaaggagccagaccc	12	6	11	12	1	1	3	0	1	1	2	2	4	1	4	4	2	3	0	4	2	3	1			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr13:37679304G>A	uc001uwm.1	-	1	498	c.90C>T	c.(88-90)GAC>GAT	p.D30D		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	30	ATP (By similarity).|Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		CCAGATAAACGTCTCCAAAGG	0.537													7	122					0	0	0	0	A	37679304	A	A	37679304	2	1	275	1	0	0	0	0	0	0	0	1	3968	1136	40	1		1	CSNK1A1L	13	37679304	Silent	SNP	G	TCGA-D6-6515-01A-21D-1870-08		37679304	77490574	30	49854											
FARP1	10160	broad.mit.edu	37	chr13	99042297	99042297	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgtgttgaacatcatgcCttctttagactttttgaaga	10	17	7	7	0	3	4	1	2	2	2	3	4	3	4	1	0	2	1	1	0	3	6			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr13:99042297C>A	uc001vnj.2	+	10	1278	c.942C>A	c.(940-942)GCC>GCA	p.A314A	FARP1_uc001vnh.2_Silent_p.A314A	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	314	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AACATCATGCCTTCTTTAGAC	0.488													7	155					2.0095e-06	2.2539e-06	1	0	A	99042297	A	A	99042297	2	1	275	1	0	0	0	0	0	0	0	1	5708	668	24	4		4	FARP1	13	99042297	Silent	SNP	C	TCGA-D6-6515-01A-21D-1870-08	61362993	99042297	16127581	31	49855											
RASA3	22821	broad.mit.edu	37	chr13	114751137	114751137	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcttatactgggcgtgcTcctgctccaaagccccaacc	7	9	7	18	1	1	0	0	0	1	0	3	0	3	0	6	1	5	2	6	1	4	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr13:114751137T>C	uc001vui.2	-	23	2509	c.2378A>G	c.(2377-2379)GAG>GGG	p.E793G	RASA3_uc010tkk.1_Missense_Mutation_p.E761G|RASA3_uc001vuj.2_Missense_Mutation_p.E410G	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	793					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			CTGGGCGTGCTCCTGCTCCAA	0.582													15	183					0	0	0	0	C	114751137	C	C	114751137	3	2	275	1	0	0	0	0	1	0	0	0	13127	1551	54	5	134	5	RASA3	13	114751137	Missense_Mutation	SNP	T	TCGA-D6-6515-01A-21D-1870-08	15708840	114751137	418741	32	49856											
MAP3K9	4293	broad.mit.edu	37	chr14	71205084	71205084	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgggacgactgagctcctGccccaggttttgctgctttc	4	14	11	12	1	0	1	0	1	0	0	2	3	1	2	3	2	4	4	3	2	0	4			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr14:71205084G>A	uc001xmm.2	-	8	1722	c.1722C>T	c.(1720-1722)GGC>GGT	p.G574G	MAP3K9_uc010ttk.1_Silent_p.G311G|MAP3K9_uc001xmk.2_Silent_p.G316G|MAP3K9_uc001xml.2_Silent_p.G574G	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	574					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CTGAGCTCCTGCCccaggttt	0.328													11	77					0	0	0	0	A	71205084	A	A	71205084	2	1	275	1	0	0	0	0	0	0	0	1	9310	1306	46	4		4	MAP3K9	14	71205084	Silent	SNP	G	TCGA-D6-6515-01A-21D-1870-08		71205084	36144456	33	49857											
C14orf179	112752	broad.mit.edu	37	chr14	76525675	76525675	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttttttgggggcagtttccGcctcagaccacagagcctga	7	11	11	12	1	1	3	1	1	0	2	2	3	2	3	4	2	1	2	4	2	0	4	rs2302858	by1000genomes	TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr14:76525675G>A	uc010asm.1	+	5	288	c.254G>A	c.(253-255)CGC>CAC	p.R85H	C14orf179_uc001xsf.2_RNA|C14orf179_uc010asl.1_Missense_Mutation_p.R85H|C14orf179_uc001xsg.2_Intron|C14orf179_uc010tve.1_RNA	NM_001102564	NP_001096034	Q96FT9	IFT43_HUMAN	hypothetical protein LOC112752 isoform 2	85					cilium morphogenesis|intraflagellar retrograde transport						0				BRCA - Breast invasive adenocarcinoma(234;0.0199)		GGCAGTTTCCGCCTCAGACCA	0.448													7	85					0	0	0	0	A	76525675	A	A	76525675	3	1	275	1	0	0	0	0	1	0	0	0	1768	1087	38	1	272	1	C14orf179	14	76525675	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	5320591	76525675	30823865	34	49858											
ATP8B4	79895	broad.mit.edu	37	chr15	50215663	50215663	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtatctgctcctttggaataAagctttatctgtccttctgg	7	17	8	9	0	3	0	0	0	3	0	5	1	5	1	2	2	2	3	2	2	5	6			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr15:50215663A>C	uc001zxu.2	-	17	1813	c.1671T>G	c.(1669-1671)CTT>CTG	p.L557L	ATP8B4_uc010ber.2_Silent_p.L430L|ATP8B4_uc010ufd.1_Silent_p.L367L|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	557	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CTTTGGAATAAAGCTTTATCT	0.383													4	40					0	0	0	0	C	50215663	C	C	50215663	2	2	275	1	0	0	0	0	0	0	0	1	1199	1	1	5		5	ATP8B4	15	50215663	Silent	SNP	A	TCGA-D6-6515-01A-21D-1870-08		50215663	52315729	35	49859											
RFX7	64864	broad.mit.edu	37	chr15	56393703	56393703	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actcacacacaagacggcaaGcagaagagataacttcttca	17	6	7	11	1	3	3	2	0	1	3	3	4	3	3	0	1	2	2	0	1	4	3			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr15:56393703G>T	uc010bfn.2	-	7	665	c.665C>A	c.(664-666)GCT>GAT	p.A222D	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Missense_Mutation_p.A36D	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	125					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						AAGACGGCAAGCAGAAGAGAT	0.423													8	47					4.1943e-16	4.76887e-16	1	0	T	56393703	T	T	56393703	3	4	275	1	0	0	0	0	1	0	0	0	13333	971	34	4	3729	4	RFX7	15	56393703	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	6178040	56393703	46137689	36	49860											
RAB11FIP3	9727	broad.mit.edu	37	chr16	546835	546835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgcacagtccgacaaagcGgctctccagcaagaaggtgg	11	6	12	12	2	2	1	0	0	2	1	4	2	3	1	2	3	3	3	2	3	3	0			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:546835G>A	uc002chf.2	+	6	1616	c.1277G>A	c.(1276-1278)CGG>CAG	p.R426Q	RAB11FIP3_uc010uuf.1_Missense_Mutation_p.R130Q|RAB11FIP3_uc010uug.1_Missense_Mutation_p.R161Q	NM_014700	NP_055515	O75154	RFIP3_HUMAN	rab11-family interacting protein 3 isoform 1	426					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding				0		Hepatocellular(16;0.0218)				CCGACAAAGCGGCTCTCCAGC	0.423													13	92					0	0	0	0	A	546835	A	A	546835	3	1	275	1	0	0	0	0	1	0	0	0	12960	1116	39	1	1318	1	RAB11FIP3	16	546835	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08		546835	89807918	37	49861											
MAPK8IP3	23162	broad.mit.edu	37	chr16	1815178	1815178	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcatctccagcatcccCggtgagcagctggagtgggc	6	8	14	13	1	1	1	0	1	1	0	3	2	2	2	3	3	4	4	3	3	0	0			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:1815178C>T	uc002cmk.2	+	20	2562	c.2442C>T	c.(2440-2442)CCC>CCT	p.P814P	MAPK8IP3_uc002cml.2_Silent_p.P808P|MAPK8IP3_uc010uvl.1_Silent_p.P815P	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	814					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CCAGCATCCCCGGTGAGCAGC	0.617													3	18					0	0	0	0	T	1815178	T	T	1815178	2	4	275	1	0	0	0	0	0	0	0	1	9339	666	23	1		1	MAPK8IP3	16	1815178	Silent	SNP	C	TCGA-D6-6515-01A-21D-1870-08	1268343	1815178	88539575	38	49862											
MYH11	4629	broad.mit.edu	37	chr16	15841500	15841500	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatcttcaaatctcgctcctCctctaggtgggccaggacgc	7	10	10	14	2	4	0	1	0	3	0	7	2	6	1	3	3	0	1	3	3	2	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:15841500C>T	uc002ddy.2	-	19	2445	c.2338G>A	c.(2338-2340)GAG>AAG	p.E780K	MYH11_uc002ddv.2_Missense_Mutation_p.E787K|MYH11_uc002ddw.2_Missense_Mutation_p.E780K|MYH11_uc002ddx.2_Missense_Mutation_p.E787K|MYH11_uc010bvg.2_Missense_Mutation_p.E612K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	780	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TCTCGCTCCTCCTCTAGGTGG	0.498			T	CBFB	AML								13	86					0	0	0	0	T	15841500	T	T	15841500	3	4	275	1	0	0	0	0	1	0	0	0	10084	864	30	2	3707	2	MYH11	16	15841500	Missense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08	14026322	15841500	74513253	39	49863											
HS3ST4	9951	broad.mit.edu	37	chr16	26147117	26147117	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agacactgtcaaagaaacccGagatccccacctttgaggtg	13	7	9	12	1	1	4	1	1	0	3	2	5	2	4	4	1	1	0	4	1	2	1			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:26147117G>A	uc002dof.2	+	2	1311	c.919G>A	c.(919-921)GAG>AAG	p.E307K		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	307	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		AAAGAAACCCGAGATCCCCAC	0.537													21	165					0	0	0	0	A	26147117	A	A	26147117	3	1	275	1	0	0	0	0	1	0	0	0	7406	1059	37	1	925	1	HS3ST4	16	26147117	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	10305617	26147117	64207636	40	49864											
FAM192A	80011	broad.mit.edu	37	chr16	57206187	57206189	+	In_Frame_Del	DEL	TTC	-	-																															tattccttcagttctttcagTtcttcttctcttcgttgctt																										TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:57206187_57206189delTTC	uc010vhk.1	-	4	581_583	c.322_324delGAA	c.(322-324)GAAdel	p.E108del	FAM192A_uc002ekz.3_In_Frame_Del_p.E108del|FAM192A_uc002ekv.3_In_Frame_Del_p.E31del|FAM192A_uc002ekw.3_In_Frame_Del_p.E108del|FAM192A_uc002ekx.3_In_Frame_Del_p.E108del|FAM192A_uc002eky.3_In_Frame_Del_p.E108del|FAM192A_uc010ccx.2_In_Frame_Del_p.E108del	NM_024946	NP_079222	Q9GZU8	F192A_HUMAN	NEFA-interacting nuclear protein NIP30	108						nucleus					0						GTTCTTTCAGTTCTTCTTCTCTT	0.355													---	---	---								-	57206189	-	-	57206187	7	5	275	1	0	1	0	1	0	0	0	0	5551	1722	60	0	456	0	FAM192A	16	57206187	In_Frame_Del	DEL	TTC	TCGA-D6-6515-01A-21D-1870-08	31059070	57206187	33148566	41	49865											
KIAA0895L	653319	broad.mit.edu	37	chr16	67213451	67213451	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggacagcaggtcctcactCagctgcaccacaacctgcag	10	6	10	15	0	2	0	2	0	0	0	3	1	3	1	3	2	5	4	3	2	1	0			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:67213451C>G	uc002ert.2	-	4	1504	c.729G>C	c.(727-729)CTG>CTC	p.L243L	KIAA0895L_uc002err.2_5'Flank|KIAA0895L_uc002ers.2_5'UTR|KIAA0895L_uc002eru.2_Silent_p.L243L|EXOC3L_uc002erv.1_RNA	NM_001040715	NP_001035805	Q68EN5	K895L_HUMAN	hypothetical protein LOC653319	243											0						GGTCCTCACTCAGCTGCACCA	0.647													4	40					0	0	0	0	G	67213451	G	G	67213451	2	3	275	1	0	0	0	0	0	0	0	1	8237	813	29	2		2	KIAA0895L	16	67213451	Silent	SNP	C	TCGA-D6-6515-01A-21D-1870-08	10007264	67213451	23141302	42	49866											
PELP1	27043	broad.mit.edu	37	chr17	4575883	4575883	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtggcacctgagggtggTgggggtggcagggggggaag	5	6	26	4	0	0	1	0	1	0	0	0	2	0	2	1	10	0	2	1	10	1	0			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:4575883T>G	uc002fyi.3	-	16	2629	c.2403A>C	c.(2401-2403)CCA>CCC	p.P801P	PELP1_uc010vsf.1_Silent_p.P654P	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	801	Pro-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						CTGAGGGTGGTGGGGGTGGCA	0.622													4	27					0	0	0	0	G	4575883	G	G	4575883	2	3	275	1	0	0	0	0	0	0	0	1	11779	1683	59	5		5	PELP1	17	4575883	Silent	SNP	T	TCGA-D6-6515-01A-21D-1870-08		4575883	76619327	43	49867											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	12	6	8	15	2	1	0	1	0	0	0	3	1	3	1	3	2	2	4	3	2	2	1	rs28934576	by1000genomes	TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	22					0	0	0	0	T	7577120	T	T	7577120	3	4	275	1	0	0	0	0	1	0	0	0	16448	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08	3001237	7577120	73618090	44	49868											
KRTAP4-1	85285	broad.mit.edu	37	chr17	39340710	39340710	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggcggcagcaagttgcacGgcagcaggtggtctgacagc	8	5	18	10	2	1	1	0	1	1	0	1	1	1	1	0	6	4	6	0	6	1	1			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:39340710G>A	uc002hwe.3	-	2	381	c.340C>T	c.(340-342)CGT>TGT	p.R114C		NM_033060	NP_149049	Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	133	16.|18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			CAAGTTGCACGGCAGCAGGTG	0.577													6	126					0	0	0	0	A	39340710	A	A	39340710	3	1	275	1	0	0	0	0	1	0	0	0	8588	1116	39	1	47	1	KRTAP4-1	17	39340710	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	31763590	39340710	41854500	45	49869											
WFIKKN2	124857	broad.mit.edu	37	chr17	48917985	48917985	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagggggaaccagcgctgtCgggcctgcaagcctcggcag	7	4	16	14	3	0	0	0	0	0	0	2	1	0	1	4	4	4	3	4	4	2	0			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:48917985C>T	uc002isv.3	+	2	2030	c.1336C>T	c.(1336-1338)CGG>TGG	p.R446W	WFIKKN2_uc010dbu.2_Missense_Mutation_p.R353W	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	446	NTR.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CCAGCGCTGTCGGGCCTGCAA	0.622													8	55					0	0	0	0	T	48917985	T	T	48917985	3	4	275	1	0	0	0	0	1	0	0	0	17427	875	31	1	1342	1	WFIKKN2	17	48917985	Missense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08	9577275	48917985	32277225	46	49870											
GDPD1	284161	broad.mit.edu	37	chr17	57298028	57298028	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggaggatacttggtgaccTcattcttgttgcttaaatac	10	15	9	7	0	2	1	1	1	1	0	2	3	2	3	1	3	3	2	1	3	5	8			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:57298028T>C	uc002ixk.1	+	1	195	c.58T>C	c.(58-60)TCA>CCA	p.S20P	GDPD1_uc002ixj.2_Missense_Mutation_p.S20P	NM_182569	NP_872375	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain	20	Helical; (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					CTTGGTGACCTCATTCTTGTT	0.542											OREG0024617	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	137					0	0	0	0	C	57298028	C	C	57298028	3	2	275	1	0	0	0	0	1	0	0	0	6360	1551	54	5	60	5	GDPD1	17	57298028	Missense_Mutation	SNP	T	TCGA-D6-6515-01A-21D-1870-08	8380043	57298028	23897182	47	49871											
LRRC37A3	374819	broad.mit.edu	37	chr17	62857035	62857035	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgcttgtgtaattcttccGggcttgtaacaccttcatga	8	15	9	9	1	2	1	1	1	1	0	3	1	3	1	2	1	2	4	2	1	2	7			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:62857035G>A	uc002jey.2	-	11	3760	c.3229C>T	c.(3229-3231)CGG>TGG	p.R1077W	LRRC37A3_uc010wqg.1_Missense_Mutation_p.R195W|LRRC37A3_uc002jex.1_Missense_Mutation_p.R54W|LRRC37A3_uc010wqf.1_Missense_Mutation_p.R115W|LRRC37A3_uc010dek.1_Missense_Mutation_p.R83W	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1077	Extracellular (Potential).					integral to membrane					0						TAATTCTTCCGGGCTTGTAAC	0.483													24	269					0	0	0	0	A	62857035	A	A	62857035	3	1	275	1	0	0	0	0	1	0	0	0	9043	1115	39	1	1691	1	LRRC37A3	17	62857035	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	5559007	62857035	18338175	48	49872											
ARHGEF18	23370	broad.mit.edu	37	chr19	7531842	7531842	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatccgatccccgtctgccCaccgtcctggagtcggaggt	6	8	12	15	4	1	0	0	0	1	0	5	4	4	2	6	3	1	0	6	3	1	0			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:7531842C>T	uc002mgi.2	+	14	2632	c.2379C>T	c.(2377-2379)CCC>CCT	p.P793P	ARHGEF18_uc010xjm.1_Silent_p.P635P|ARHGEF18_uc002mgh.2_Silent_p.P635P|ARHGEF18_uc002mgj.1_Silent_p.P436P	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	793					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				CCCGTCTGCCCACCGTCCTGG	0.637													11	68					0	0	0	0	T	7531842	T	T	7531842	2	4	275	1	0	0	0	0	0	0	0	1	901	581	21	4		4	ARHGEF18	19	7531842	Silent	SNP	C	TCGA-D6-6515-01A-21D-1870-08		7531842	51597141	49	49873											
CD97	976	broad.mit.edu	37	chr19	14508888	14508888	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcagacgctttcccgattCttcgacaaagtccaggacct	9	10	8	14	3	1	1	0	0	1	1	4	4	3	2	3	1	1	2	3	1	1	3			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:14508888C>T	uc002myl.2	+	9	957	c.834C>T	c.(832-834)TTC>TTT	p.F278F	CD97_uc002mym.2_Silent_p.F229F|CD97_uc002myn.2_Silent_p.F185F	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	278	Extracellular (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						TTTCCCGATTCTTCGACAAAG	0.587													5	74					0	0	0	0	T	14508888	T	T	14508888	2	4	275	1	0	0	0	0	0	0	0	1	3064	912	32	2		2	CD97	19	14508888	Silent	SNP	C	TCGA-D6-6515-01A-21D-1870-08	6977046	14508888	44620095	50	49874											
USHBP1	83878	broad.mit.edu	37	chr19	17373676	17373676	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggccccattcccagggggCacagtctccttgtactgtag	6	9	13	13	0	1	0	0	0	1	0	3	0	2	0	4	4	1	3	4	4	2	4			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:17373676C>T	uc002nfs.1	-	4	440	c.327G>A	c.(325-327)GTG>GTA	p.V109V	USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Silent_p.V45V|USHBP1_uc010eam.1_Silent_p.V37V	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	109							PDZ domain binding			ovary(1)	1						TCCCAGGGGGCACAGTCTCCT	0.667													14	102					0	0	0	0	T	17373676	T	T	17373676	2	4	275	1	0	0	0	0	0	0	0	1	17105	697	25	4		4	USHBP1	19	17373676	Silent	SNP	C	TCGA-D6-6515-01A-21D-1870-08	2864788	17373676	41755307	51	49875											
LYPD3	27076	broad.mit.edu	37	chr19	43965777	43965777	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctggggccgaggtagaagtgGtgacagatgtggttgaggcc	8	8	19	6	1	0	4	0	2	0	2	0	5	0	4	2	6	0	2	2	6	2	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:43965777G>A	uc002owl.1	-	5	875	c.767C>T	c.(766-768)ACC>ATC	p.T256I	LYPD3_uc002owm.2_3'UTR	NM_014400	NP_055215	O95274	LYPD3_HUMAN	GPI-anchored metastasis-associated protein	256						anchored to plasma membrane				pancreas(1)	1		Prostate(69;0.0153)				GGTAGAAGTGGTGACAGATGT	0.612													20	118					0	0	0	0	A	43965777	A	A	43965777	3	1	275	1	0	0	0	0	1	0	0	0	9162	1261	44	4	277	4	LYPD3	19	43965777	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	26592101	43965777	15163206	52	49876											
CACNG7	59284	broad.mit.edu	37	chr19	54418666	54418666	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatggtcagcctcttcctcGtgttcacggccttcgtcatc	4	13	8	16	3	4	0	3	0	1	0	8	0	5	0	4	2	1	1	4	2	0	3			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:54418666G>A	uc002qcr.1	+	3	346	c.331G>A	c.(331-333)GTG>ATG	p.V111M	CACNG7_uc010era.1_Missense_Mutation_p.V111M	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	111	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		CCTCTTCCTCGTGTTCACGGC	0.607													9	49					0	0	0	0	A	54418666	A	A	54418666	3	1	275	1	0	0	0	0	1	0	0	0	2574	1145	40	1	341	1	CACNG7	19	54418666	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	10452889	54418666	4710317	53	49877											
NLRP8	126205	broad.mit.edu	37	chr19	56466997	56466997	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttatgttctctgtttcccaCaaagactcaaaaattttcat	12	17	3	9	0	3	1	2	0	1	1	5	1	4	1	1	0	0	2	1	0	4	6			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:56466997C>T	uc002qmh.2	+	3	1644	c.1573C>T	c.(1573-1575)CAA>TAA	p.Q525*	NLRP8_uc010etg.2_Nonsense_Mutation_p.Q525*	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	525	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTGTTTCCCACAAAGACTCAA	0.433													8	171					0	0	0	0	T	56466997	T	T	56466997	4	4	275	1	0	0	0	0	0	1	0	0	10537	479	17	4	1583	4	NLRP8	19	56466997	Nonsense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08	2048331	56466997	2661986	54	49878											
C20orf54	113278	broad.mit.edu	37	chr20	746115	746115	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggcgatgctgtggtggcCgtccagcacccaggaggtca	8	6	16	11	2	1	0	1	0	0	0	2	3	2	1	3	5	2	2	3	5	1	0			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr20:746115C>T	uc002wed.3	-	2	643	c.304G>A	c.(304-306)GGC>AGC	p.G102S	C20orf54_uc002wee.2_Missense_Mutation_p.G102S	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	102	Helical; (Potential).				sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						CTGTGGTGGCCGTCCAGCACC	0.597													3	10					0	0	0	0	T	746115	T	T	746115	3	4	275	1	0	0	0	0	1	0	0	0	2124	652	23	1	1121	1	C20orf54	20	746115	Missense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08		746115	62279405	55	49879											
ZNFX1	57169	broad.mit.edu	37	chr20	47863942	47863942	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgtgccaccaatcacttcCttacagtcaggacacgtgcc	9	11	7	14	1	2	0	2	0	0	0	3	1	3	1	4	1	3	0	4	1	2	3			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr20:47863942C>T	uc002xui.2	-	14	5866	c.5619G>A	c.(5617-5619)AAG>AAA	p.K1873K		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1873							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CAATCACTTCCTTACAGTCAG	0.527													10	66					0	0	0	0	T	47863942	T	T	47863942	2	4	275	1	0	0	0	0	0	0	0	1	18272	680	24	4		4	ZNFX1	20	47863942	Silent	SNP	C	TCGA-D6-6515-01A-21D-1870-08	47117827	47863942	15161578	56	49880											
OLIG2	10215	broad.mit.edu	37	chr21	34399432	34399432	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacctcgtcgtctacgtcgTcggcggctgcgtcgtccacc	3	9	12	17	8	1	0	0	0	1	0	7	0	2	0	3	2	2	2	3	2	1	1			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr21:34399432T>G	uc002yqx.1	+	2	420	c.262T>G	c.(262-264)TCG>GCG	p.S88A		NM_005806	NP_005797	Q13516	OLIG2_HUMAN	oligodendrocyte lineage transcription factor 2	88	Poly-Ser.					cytoplasm|nucleus|plasma membrane	DNA binding			central_nervous_system(2)	2						GTCTACGTCGTCGGCGGCTGC	0.632			T	TRA@	T-ALL								6	18					0	0	0	0	G	34399432	G	G	34399432	3	3	275	1	0	0	0	0	1	0	0	0	10915	1667	58	5	264	5	OLIG2	21	34399432	Missense_Mutation	SNP	T	TCGA-D6-6515-01A-21D-1870-08		34399432	13730463	57	49881											
ZC3H7B	23264	broad.mit.edu	37	chr22	41752766	41752766	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtccgacagtgacgccagcGgctgggccttccgcttcccc	4	7	12	18	5	0	1	0	1	0	0	3	2	3	1	6	2	1	2	6	2	0	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr22:41752766G>A	uc003azw.2	+	22	2851	c.2635G>A	c.(2635-2637)GGC>AGC	p.G879S	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	895					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						TGACGCCAGCGGCTGGGCCTT	0.647													4	115					0	0	0	0	A	41752766	A	A	41752766	3	1	275	1	0	0	0	0	1	0	0	0	17640	1116	39	1	2717	1	ZC3H7B	22	41752766	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08		41752766	9551800	58	49882											
DUSP21	63904	broad.mit.edu	37	chrX	44703847	44703847	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggaacagctcatcaattacGaattcaagctgtttaataac	15	11	7	8	1	3	0	3	0	0	0	3	2	3	1	0	1	5	3	0	1	7	5			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:44703847G>A	uc004dgd.2	+	1	599	c.469G>A	c.(469-471)GAA>AAA	p.E157K		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	157	Tyrosine-protein phosphatase.					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						CATCAATTACGAATTCAAGCT	0.498													9	54					0	0	0	0	A	44703847	A	A	44703847	3	1	275	1	0	0	0	0	1	0	0	0	4842	1059	37	1	471	1	DUSP21	23	44703847	Missense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08		44703847	110566713	59	49883											
ZNF41	7592	broad.mit.edu	37	chrX	47308645	47308646	+	Frame_Shift_Ins	INS	-	T	T																															cttggtagtcacatgaattaINSttttttcaatgtttttatgt																										TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:47308645_47308646insT	uc004dhs.3	-	4	716_717	c.649_650insA	c.(649-651)ATAfs	p.I217fs	ZNF41_uc004dhu.3_Frame_Shift_Ins_p.I209fs|ZNF41_uc004dht.3_Frame_Shift_Ins_p.I89fs|ZNF41_uc004dhv.3_Frame_Shift_Ins_p.I185fs|ZNF41_uc004dhw.3_Frame_Shift_Ins_p.I177fs|ZNF41_uc004dhy.3_Frame_Shift_Ins_p.I175fs|ZNF41_uc004dhx.3_Frame_Shift_Ins_p.I175fs|ZNF41_uc011mlm.1_Frame_Shift_Ins_p.I89fs	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	217						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				CACATGAATTATTTTTTCAATG	0.332													---	---	---								T	47308646	T	T	47308645	7	5	275	1	0	1	1	0	0	0	0	0	17956	449	16	0	1819	0	ZNF41	23	47308645	Frame_Shift_Ins	INS	-	TCGA-D6-6515-01A-21D-1870-08	2604798	47308645	107961915	60	49884											
NUDT11	55190	broad.mit.edu	37	chrX	51238820	51238820	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactagggatcgctatctggCgaggatggggccatggagtt	8	10	16	7	2	1	0	0	0	1	0	2	4	1	3	1	6	1	2	1	6	3	4			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:51238820C>T	uc010njt.2	-	1	640	c.477G>A	c.(475-477)TCG>TCA	p.S159S		NM_018159	NP_060629	Q96G61	NUD11_HUMAN	nudix-type motif 11	159						cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0	Ovarian(276;0.236)					CGCTATCTGGCGAGGATGGGG	0.562										HNSCC(48;0.14)			4	31					0	0	0	0	T	51238820	T	T	51238820	2	4	275	1	0	0	0	0	0	0	0	1	10781	755	27	1		1	NUDT11	23	51238820	Silent	SNP	C	TCGA-D6-6515-01A-21D-1870-08	3930175	51238820	104031740	61	49885											
PCDH11X	27328	broad.mit.edu	37	chrX	91133558	91133558	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgtcaatctgttcgtgaaTgagtcggtgaccaatgctac	10	13	10	8	2	2	3	1	3	1	0	4	3	2	3	1	1	2	2	1	1	4	3			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:91133558T>A	uc004efk.1	+	2	3164	c.2319T>A	c.(2317-2319)AAT>AAA	p.N773K	PCDH11X_uc004efl.1_Missense_Mutation_p.N773K|PCDH11X_uc004efo.1_Missense_Mutation_p.N773K|PCDH11X_uc010nmv.1_Missense_Mutation_p.N773K|PCDH11X_uc004efm.1_Missense_Mutation_p.N773K|PCDH11X_uc004efn.1_Missense_Mutation_p.N773K|PCDH11X_uc004efh.1_Missense_Mutation_p.N773K|PCDH11X_uc004efj.1_Missense_Mutation_p.N773K	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	773	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TGTTCGTGAATGAGTCGGTGA	0.433													15	124					0	0	0	0	A	91133558	A	A	91133558	3	1	275	1	0	0	0	0	1	0	0	0	11562	1461	51	5	2325	5	PCDH11X	23	91133558	Missense_Mutation	SNP	T	TCGA-D6-6515-01A-21D-1870-08	39894738	91133558	64137002	62	49886											
SMARCA1	6594	broad.mit.edu	37	chrX	128615129	128615129	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtagtttgctttgcgttctcGtttaggaggttcaatccatt	6	18	10	7	2	2	0	1	0	1	0	4	1	3	1	1	2	2	6	1	2	3	8			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:128615129G>A	uc004eun.3	-	18	2364	c.2251C>T	c.(2251-2253)CGA>TGA	p.R751*	SMARCA1_uc004eup.3_Nonsense_Mutation_p.R739*|SMARCA1_uc011muk.1_Nonsense_Mutation_p.R751*|SMARCA1_uc011mul.1_Nonsense_Mutation_p.R739*	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	751					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						TTGCGTTCTCGTTTAGGAGGT	0.423													11	49					0	0	0	0	A	128615129	A	A	128615129	4	1	275	1	0	0	0	0	0	1	0	0	14832	1153	40	1	941	1	SMARCA1	23	128615129	Nonsense_Mutation	SNP	G	TCGA-D6-6515-01A-21D-1870-08	37481571	128615129	26655431	63	49887											
PNMA3	29944	broad.mit.edu	37	chrX	152226306	152226306	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actcgcctgaaacgagtcttAagtggggccacccttcctga	9	9	10	13	2	1	2	0	2	1	0	3	3	2	2	4	2	1	0	4	2	2	2			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:152226306A>G	uc004fhc.2	+	2	1230	c.894A>G	c.(892-894)TTA>TTG	p.L298L	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	298					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					aacgagtcttaagtggggcca	0													6	63					0	0	0	0	G	152226306	G	G	152226306	2	3	275	1	0	0	0	0	0	0	0	1	12210	359	13	5		5	PNMA3	23	152226306	Silent	SNP	A	TCGA-D6-6515-01A-21D-1870-08	23611177	152226306	3044254	64	49888											
F8	2157	broad.mit.edu	37	chrX	154250784	154250784	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtggcactaaagcagaatCgcaaaaggcacagaaagaag	18	4	12	7	1	0	3	0	0	0	3	1	3	0	3	0	3	1	4	0	3	7	1			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:154250784C>T	uc004fmt.2	-	1	215	c.44G>A	c.(43-45)CGA>CAA	p.R15Q	F8_uc011mzx.1_Intron	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	15					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AAAGCAGAATCGCAAAAGGCA	0.448													4	117					0	0	0	0	T	154250784	T	T	154250784	3	4	275	1	0	0	0	0	1	0	0	0	5375	884	31	1	7143	1	F8	23	154250784	Missense_Mutation	SNP	C	TCGA-D6-6515-01A-21D-1870-08	2024478	154250784	1019776	65	49889											
KLHL17	339451	broad.mit.edu	37	chr1	900538	900538	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aatttcccgccgccatcctcCccgacgctgtccgtgtcctc	4	10	7	20	5	0	0	0	0	0	0	6	1	5	0	8	0	0	1	8	0	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:900538C>T	uc001aca.1	+	12	2003	c.1896C>T	c.(1894-1896)TCC>TCT	p.S632S	KLHL17_uc001acc.1_RNA|PLEKHN1_uc001acd.2_5'Flank|PLEKHN1_uc001acf.2_5'Flank|PLEKHN1_uc001ace.2_5'Flank	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	632	Interaction with F-actin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CGCCATCCTCCCCGACGCTGT	0.667													7	17					0	0	0	0	T	900538	T	T	900538	2	4	276	1	0	0	0	0	0	0	0	1	8411	610	22	4		4	KLHL17	1	900538	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08		900538	248350083	1	49890											
CCNL2	81669	broad.mit.edu	37	chr1	1322774	1322774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgacctgcttcgagaacggGaagaactccggctccgagac	10	6	13	12	4	0	4	0	1	0	3	3	7	2	5	3	2	3	2	3	2	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:1322774G>A	uc001afi.2	-	11	1432	c.1400C>T	c.(1399-1401)TCC>TTC	p.S467F	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Missense_Mutation_p.S245F|CCNL2_uc001afg.1_Missense_Mutation_p.S245F|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	467					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		TCGAGAACGGGAAGAACTCCG	0.572													27	83					0	0	0	0	A	1322774	A	A	1322774	3	1	276	1	0	0	0	0	1	0	0	0	2947	1174	41	2	166	2	CCNL2	1	1322774	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	422236	1322774	247927847	2	49891											
CCNL2	81669	broad.mit.edu	37	chr1	1322852	1322852	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccgggagccccgaatctcaGagcctttgtagggagcgctg	7	8	14	12	3	1	1	1	0	1	1	3	4	2	3	4	2	3	2	4	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:1322852G>A	uc001afi.2	-	11	1354	c.1322C>T	c.(1321-1323)TCT>TTT	p.S441F	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Missense_Mutation_p.S219F|CCNL2_uc001afg.1_Missense_Mutation_p.S219F|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	441					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CCGAATCTCAGAGCCTTTGTA	0.642													9	28					0	0	0	0	A	1322852	A	A	1322852	3	1	276	1	0	0	0	0	1	0	0	0	2947	942	33	2	244	2	CCNL2	1	1322852	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	78	1322852	247927769	3	49892											
PRKCZ	5590	broad.mit.edu	37	chr1	2103808	2103808	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aattacatcgcccccgaaatCctgcggggagaggagtacgg	11	6	13	11	4	0	1	0	0	0	1	2	4	1	2	3	4	3	1	3	4	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:2103808C>T	uc001aiq.2	+	13	1427	c.1266C>T	c.(1264-1266)ATC>ATT	p.I422I	PRKCZ_uc001air.2_Silent_p.I239I|PRKCZ_uc010nyw.1_Silent_p.I318I|PRKCZ_uc001ais.2_Silent_p.I239I|PRKCZ_uc009vla.2_Silent_p.I246I|PRKCZ_uc010nyx.1_RNA|PRKCZ_uc001ait.2_Silent_p.I270I	NM_002744	NP_002735	Q05513	KPCZ_HUMAN	protein kinase C, zeta isoform 1	422	Protein kinase.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CCCCCGAAATCCTGCGGGGAG	0.647													4	12					0	0	0	0	T	2103808	T	T	2103808	2	4	276	1	0	0	0	0	0	0	0	1	12579	845	30	2		2	PRKCZ	1	2103808	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	780956	2103808	247146813	4	49893											
SKI	6497	broad.mit.edu	37	chr1	2234517	2234518	+	Missense_Mutation	DNP	GG	AA	AA																															caagccgtccagctggctgcGgaccttggccggctcttcca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:2234517_2234518GG>AA	uc001aja.3	+	2	1142_1143	c.1070_1071GG>AA	c.(1069-1071)CGG>CAA	p.R357Q		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	357					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		AGCTGGCTGCGGACCTTGGCCG	0.639													16	45					0	0	0	0	AA	2234518	AA	AA	2234517	3	1	276	1	0	0	0	0	1	0	0	0	14422	1116	39	1	1076	1	SKI	1	2234517	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	130709	2234517	247016104	5	49894											
PRDM16	63976	broad.mit.edu	37	chr1	3313153	3313154	+	Missense_Mutation	DNP	GG	AA	AA																															ggcacagtgccgcccggcctGgacggtaagacccctccccc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:3313153_3313154GG>AA	uc001akf.2	+	5	752_753	c.672_673GG>AA	c.(670-675)CTGGAC>CTAAAC	p.D225N	PRDM16_uc001akc.2_Missense_Mutation_p.D225N|PRDM16_uc001akd.2_Missense_Mutation_p.D225N|PRDM16_uc001ake.2_Missense_Mutation_p.D225N|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	225					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CGCCCGGCCTGGACGGTAAGAC	0.634			T	EVI1	MDS|AML								4	6					0	0	0	0	AA	3313154	AA	AA	3313153	3	1	276	1	0	0	0	0	1	0	0	0	12519	1335	47	4	690	4	PRDM16	1	3313153	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	1078636	3313153	245937468	6	49895											
PLEKHG5	57449	broad.mit.edu	37	chr1	6536025	6536025	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agagctctcctcctcctcctCctccaagtccactgcggggc	5	9	8	19	1	1	1	0	0	1	1	8	1	7	1	7	2	2	1	7	2	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:6536025C>T	uc001ano.1	-	4	384	c.283G>A	c.(283-285)GAG>AAG	p.E95K	PLEKHG5_uc001ann.1_Missense_Mutation_p.E76K|PLEKHG5_uc001anq.1_Missense_Mutation_p.E116K|PLEKHG5_uc001anp.1_Missense_Mutation_p.E116K|PLEKHG5_uc009vma.1_5'UTR|PLEKHG5_uc010nzr.1_Missense_Mutation_p.E108K|PLEKHG5_uc001ank.1_Missense_Mutation_p.E39K|PLEKHG5_uc009vmb.1_Missense_Mutation_p.E39K|PLEKHG5_uc001anl.1_Missense_Mutation_p.E39K|PLEKHG5_uc001anm.1_Missense_Mutation_p.E39K	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	95	Poly-Glu.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		TCCTCCTCCTCCTCCAAGTCC	0.642											OREG0013041	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	47					0	0	0	0	T	6536025	T	T	6536025	3	4	276	1	0	0	0	0	1	0	0	0	12128	864	30	2	2981	2	PLEKHG5	1	6536025	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3222872	6536025	242714596	7	49896											
ZBTB48	3104	broad.mit.edu	37	chr1	6640991	6640991	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agttgcgagtgccagaggccGtagagctgtgccagagcttc	8	8	15	10	2	0	3	0	0	0	3	1	4	0	3	3	1	5	4	3	1	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:6640991G>A	uc009vmc.1	+	2	445	c.322G>A	c.(322-324)GTA>ATA	p.V108I	ZBTB48_uc001anx.2_Missense_Mutation_p.V108I|ZBTB48_uc009vmd.1_Missense_Mutation_p.V108I	NM_005341	NP_005332	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	108						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		GCCAGAGGCCGTAGAGCTGTG	0.607													6	30					0	0	0	0	A	6640991	A	A	6640991	3	1	276	1	0	0	0	0	1	0	0	0	17616	1145	40	1	324	1	ZBTB48	1	6640991	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	104966	6640991	242609630	8	49897											
ZBTB48	3104	broad.mit.edu	37	chr1	6642211	6642211	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggaagtcaaatgtaatcCgaaagccctgtgcagctgag	13	7	13	8	1	1	1	1	1	0	0	2	4	2	3	2	2	3	3	2	2	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:6642211C>T	uc009vmc.1	+	3	907	c.784C>T	c.(784-786)CGA>TGA	p.R262*	ZBTB48_uc001anx.2_Nonsense_Mutation_p.R262*|ZBTB48_uc009vmd.1_Nonsense_Mutation_p.R262*	NM_005341	NP_005332	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	262						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		AAATGTAATCCGAAAGCCCTG	0.582													7	20					0	0	0	0	T	6642211	T	T	6642211	4	4	276	1	0	0	0	0	0	1	0	0	17616	644	23	1	790	1	ZBTB48	1	6642211	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1220	6642211	242608410	9	49898											
PER3	8863	broad.mit.edu	37	chr1	7902768	7902768	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgaagattcagctgatGgtgcggccacatcctgtggt	11	10	12	8	1	1	3	1	2	0	1	2	3	2	3	2	3	2	1	2	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:7902768G>A	uc001aoo.2	+	21	3734	c.3559G>A	c.(3559-3561)GGT>AGT	p.G1187S	PER3_uc001aop.2_Missense_Mutation_p.G1196S|PER3_uc010nzw.1_Missense_Mutation_p.G876S	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	1187	CRY binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TTCAGCTGATGGTGCGGCCAC	0.448													17	56					0	0	0	0	A	7902768	A	A	7902768	3	1	276	1	0	0	0	0	1	0	0	0	11785	1348	47	4	3641	4	PER3	1	7902768	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1260557	7902768	241347853	10	49899											
UBE4B	10277	broad.mit.edu	37	chr1	10166447	10166447	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcggtatcgcccctacacTgtcactcacccatgggcgtc	6	8	9	18	4	2	0	2	0	0	0	4	0	2	0	4	2	1	1	4	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:10166447T>G	uc001aqs.3	+	7	1715	c.1002T>G	c.(1000-1002)ACT>ACG	p.T334T	UBE4B_uc001aqr.3_Intron|UBE4B_uc010oai.1_Intron|UBE4B_uc010oaj.1_Intron	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	334					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GCCCCTACACTGTCACTCACC	0.647													18	61					0	0	0	0	G	10166447	G	G	10166447	2	3	276	1	0	0	0	0	0	0	0	1	16951	1567	55	5		5	UBE4B	1	10166447	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	2263679	10166447	239084174	11	49900											
MASP2	10747	broad.mit.edu	37	chr1	11105536	11105536	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtagaaaccgcccaggtggTtgtggcagtggtggtcgcag	8	8	17	8	2	0	1	0	0	0	1	1	1	0	1	2	5	1	4	2	5	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:11105536T>C	uc001aru.2	-	4	494	c.473A>G	c.(472-474)AAC>AGC	p.N158S	MASP2_uc001arv.2_Missense_Mutation_p.N158S|MASP2_uc001arw.2_3'UTR|MASP2_uc001arx.1_Missense_Mutation_p.N158S	NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	158	EGF-like; calcium-binding.	Calcium 2.			complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		GCCCAGGTGGTTGTGGCAGTG	0.682													12	22					0	0	0	0	C	11105536	C	C	11105536	3	2	276	1	0	0	0	0	1	0	0	0	9376	1725	60	5	1637	5	MASP2	1	11105536	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	939089	11105536	238145085	12	49901											
CLCN6	1185	broad.mit.edu	37	chr1	11887266	11887266	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccttctggaaccaagggctCacgtggaaagtggtgaggag	10	8	15	8	1	2	1	1	1	1	0	3	4	3	4	2	5	1	1	2	5	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:11887266C>T	uc001ate.3	+	10	941	c.828C>T	c.(826-828)CTC>CTT	p.L276L	CLCN6_uc009vnf.1_Missense_Mutation_p.H280Y|CLCN6_uc009vng.1_Missense_Mutation_p.H268Y|CLCN6_uc009vnh.1_Silent_p.L276L|CLCN6_uc010oat.1_5'UTR|CLCN6_uc010oau.1_Silent_p.L254L	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	276					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		ACCAAGGGCTCACGTGGAAAG	0.552													11	45					0	0	0	0	T	11887266	T	T	11887266	2	4	276	1	0	0	0	0	0	0	0	1	3482	826	29	2		2	CLCN6	1	11887266	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	781730	11887266	237363355	13	49902											
LOC649330	649330	broad.mit.edu	37	chr1	12907779	12907779	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgggaaactgtacattcCatcataataatcccgttgaa	13	12	7	9	1	1	1	1	1	0	0	3	2	3	2	2	1	3	3	2	1	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:12907779C>T	uc009vno.2	-	1	459	c.364G>A	c.(364-366)GGG>AGG	p.G122R	HNRNPCL1_uc010obf.1_Missense_Mutation_p.G122R	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	122							nucleic acid binding|nucleotide binding				0						CTGTACATTCCATCATAATAA	0.498													13	61					0	0	0	0	T	12907779	T	T	12907779	3	4	276	1	0	0	0	0	1	0	0	0	8935	603	21	4	521	4	LOC649330	1	12907779	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1020513	12907779	236342842	14	49903											
PRAMEF10	343071	broad.mit.edu	37	chr1	12955430	12955430	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccaccagtgtatcaagtccCctcaggacagcttgcaaggt	10	8	10	13	0	2	0	2	0	0	0	3	1	3	1	4	2	2	3	4	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:12955430C>T	uc001auo.2	-	2	322	c.249G>A	c.(247-249)AGG>AGA	p.R83R		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	83											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TATCAAGTCCCCTCAGGACAG	0.607													15	39					0	0	0	0	T	12955430	T	T	12955430	2	4	276	1	0	0	0	0	0	0	0	1	12486	622	22	4		4	PRAMEF10	1	12955430	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	47651	12955430	236295191	15	49904											
TMEM51	55092	broad.mit.edu	37	chr1	15541602	15541603	+	Frame_Shift_Del	DEL	GC	-	-																															acatgatggcccagtccaagGccaatggctcgcactatgcg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:15541602_15541603delGC	uc001avw.3	+	3	538_539	c.19_20delGC	c.(19-21)GCCfs	p.A7fs	TMEM51_uc010obk.1_Frame_Shift_Del_p.A7fs|TMEM51_uc001avz.2_Frame_Shift_Del_p.A7fs|TMEM51_uc001avy.2_Frame_Shift_Del_p.A7fs|TMEM51_uc001avx.2_Frame_Shift_Del_p.A7fs	NM_001136216	NP_001129688	Q9NW97	TMM51_HUMAN	transmembrane protein 51	7						integral to membrane					0		Renal(390;0.00145)|Breast(348;0.00186)|Colorectal(325;0.00215)|all_lung(284;0.00459)|Lung NSC(340;0.0104)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;2.07e-06)|COAD - Colon adenocarcinoma(227;7.14e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000175)|KIRC - Kidney renal clear cell carcinoma(229;0.00141)|STAD - Stomach adenocarcinoma(313;0.00644)|READ - Rectum adenocarcinoma(331;0.0751)		CCAGTCCAAGGCCAATGGCTCG	0.569													---	---	---								-	15541603	-	-	15541602	7	5	276	1	0	1	0	1	0	0	0	0	16243	1203	42	0	21	0	TMEM51	1	15541602	Frame_Shift_Del	DEL	GC	TCGA-D6-6516-01A-11D-1870-08	2586172	15541602	233709019	16	49905											
CELA2B	51032	broad.mit.edu	37	chr1	15812401	15812401	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctggtctcattcagccaacGgggctctccctgatgacctg	6	11	10	14	1	4	2	2	2	3	0	6	2	4	2	3	3	2	1	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:15812401G>A	uc001awl.2	+	6	524	c.499G>A	c.(499-501)GGG>AGG	p.G167R		NM_015849	NP_056933	P08218	CEL2B_HUMAN	elastase 2B preproprotein	167	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						TTCAGCCAACGGGGCTCTCCC	0.562													39	116					0	0	0	0	A	15812401	A	A	15812401	3	1	276	1	0	0	0	0	1	0	0	0	3227	1116	39	1	521	1	CELA2B	1	15812401	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	270799	15812401	233438220	17	49906											
FBLIM1	54751	broad.mit.edu	37	chr1	16093894	16093894	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccaccccctcctcctgtcCtggatggtgaggacgtgctt	4	10	11	16	1	0	1	0	1	0	0	3	3	3	3	6	3	1	1	6	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:16093894C>T	uc001axd.1	+	5	717	c.274C>T	c.(274-276)CTG>TTG	p.L92L	FBLIM1_uc001axe.1_Silent_p.L92L|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axg.1_Silent_p.L92L|FBLIM1_uc001axh.1_Intron|FBLIM1_uc001axi.1_Intron	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	92	Pro-rich.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		TCCTCCTGTCCTGGATGGTGA	0.627													3	27					0	0	0	0	T	16093894	T	T	16093894	2	4	276	1	0	0	0	0	0	0	0	1	5729	680	24	4		4	FBLIM1	1	16093894	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	281493	16093894	233156727	18	49907											
ACTL8	81569	broad.mit.edu	37	chr1	18149591	18149591	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atgagcctcagatggtcttcCcgaacatcgtgaactaccta	11	10	8	12	2	2	3	1	2	1	1	4	4	3	3	3	1	4	0	3	1	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:18149591C>T	uc001bat.2	+	2	304	c.88C>T	c.(88-90)CCG>TCG	p.P30S		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	30						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		GATGGTCTTCCCGAACATCGT	0.582													15	36					0	0	0	0	T	18149591	T	T	18149591	3	4	276	1	0	0	0	0	1	0	0	0	202	623	22	4	90	4	ACTL8	1	18149591	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2055697	18149591	231101030	19	49908											
KLHDC7A	127707	broad.mit.edu	37	chr1	18809042	18809042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgtctggcgcccgctggctCgcatgccccccgaggccgtg	3	7	14	17	5	1	0	0	0	1	0	2	1	1	0	5	3	1	3	5	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:18809042C>T	uc001bax.2	+	1	1619	c.1567C>T	c.(1567-1569)CGC>TGC	p.R523C	KLHDC7A_uc009vpg.2_Missense_Mutation_p.R305C	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	523	Kelch 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCGCTGGCTCGCATGCCCCC	0.672													14	41					0	0	0	0	T	18809042	T	T	18809042	3	4	276	1	0	0	0	0	1	0	0	0	8399	884	31	1	1569	1	KLHDC7A	1	18809042	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	659451	18809042	230441579	20	49909											
UBR4	23352	broad.mit.edu	37	chr1	19447897	19447897	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gacacgccctcatccacaagGaaactgacttggaggaggaa	14	5	11	11	1	1	1	1	1	0	0	2	6	2	5	2	4	1	0	2	4	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:19447897G>A	uc001bbi.2	-	68	9931	c.9927C>T	c.(9925-9927)TTC>TTT	p.F3309F	UBR4_uc001bbk.1_Silent_p.F956F	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3309					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CATCCACAAGGAAACTGACTT	0.582													5	35					0	0	0	0	A	19447897	A	A	19447897	2	1	276	1	0	0	0	0	0	0	0	1	16972	1165	41	2		2	UBR4	1	19447897	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	638855	19447897	229802724	21	49910											
AKR7A2	8574	broad.mit.edu	37	chr1	19630782	19630782	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcttgattaaaggcatccacGacagccggctccaggggccc	9	6	12	14	2	0	1	0	1	0	0	2	2	2	1	4	4	1	3	4	4	2	2	rs148319333		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:19630782G>A	uc001bbw.2	-	7	1039	c.1017C>T	c.(1015-1017)GTC>GTT	p.V339V	AKR7A2_uc001bbx.2_Silent_p.V304V	NM_003689	NP_003680	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2	339					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		AGGCATCCACGACAGCCGGCT	0.602													26	42					0	0	0	0	A	19630782	A	A	19630782	2	1	276	1	0	0	0	0	0	0	0	1	475	1045	37	1		1	AKR7A2	1	19630782	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	182885	19630782	229619839	22	49911											
AKR7A2	8574	broad.mit.edu	37	chr1	19630871	19630871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccaggatgaccgcgtcccCgtgggcaccctgcaagggag	7	4	15	15	3	0	1	0	1	0	0	1	3	1	3	5	3	1	2	5	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:19630871C>T	uc001bbw.2	-	7	950	c.928G>A	c.(928-930)GGG>AGG	p.G310R	AKR7A2_uc001bbx.2_Missense_Mutation_p.G275R	NM_003689	NP_003680	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2	310					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ACCGCGTCCCCGTGGGCACCC	0.647													29	67					0	0	0	0	T	19630871	T	T	19630871	3	4	276	1	0	0	0	0	1	0	0	0	475	652	23	1	155	1	AKR7A2	1	19630871	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	89	19630871	229619750	23	49912											
PLA2G5	5322	broad.mit.edu	37	chr1	20417131	20417132	+	Silent	DNP	CC	TT	TT																															gtctactgcctcaagagaaaCctacggagctacaacccaca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:20417131_20417132CC>TT	uc001bcy.2	+	5	631_632	c.363_364CC>TT	c.(361-366)AACCTA>AATTTA	p.121_122NL>NL	PLA2G5_uc001bcw.2_RNA|PLA2G5_uc001bcx.2_Silent_p.152_153NL>NL	NM_000929	NP_000920	P39877	PA2G5_HUMAN	phospholipase A2, group V precursor	121_122					lipid catabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000249)|Lung NSC(340;0.000287)|Breast(348;0.000812)|Ovarian(437;0.00328)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;8.15e-05)|Kidney(64;0.000184)|GBM - Glioblastoma multiforme(114;0.00089)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0652)		TCAAGAGAAACCTACGGAGCTA	0.54													24	76					0	0	0	0	TT	20417132	TT	TT	20417131	2	4	276	1	0	0	0	0	0	0	0	1	12062	506	18	4		4	PLA2G5	1	20417131	Silent	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	786260	20417131	228833490	24	49913											
MAN1C1	57134	broad.mit.edu	37	chr1	26012975	26012975	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tataagcgttatgcaatgggGaaaaacgaactccgtccact	14	9	9	9	3	0	0	0	0	0	0	2	2	2	1	2	2	4	2	2	2	7	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:26012975G>A	uc001bkm.2	+	2	915	c.585G>A	c.(583-585)GGG>GGA	p.G195G	MAN1C1_uc009vry.1_Silent_p.G15G	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	195	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		ATGCAATGGGGAAAAACGAAC	0.498													33	95					0	0	0	0	A	26012975	A	A	26012975	2	1	276	1	0	0	0	0	0	0	0	1	9266	1161	41	2		2	MAN1C1	1	26012975	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5595844	26012975	223237646	25	49914											
SLC30A2	7780	broad.mit.edu	37	chr1	26366380	26366380	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagatcacgaacagctgtGaagtcaacgcccttgggggt	11	7	13	10	2	2	2	2	1	0	1	2	3	2	2	1	2	4	2	1	2	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:26366380G>A	uc001blh.1	-	6	931	c.714C>T	c.(712-714)TTC>TTT	p.F238F	SLC30A2_uc001blg.1_Silent_p.F287F	NM_032513	NP_115902	Q9BRI3	ZNT2_HUMAN	solute carrier family 30, member 2 isoform 2	238	Cytoplasmic (Potential).				positive regulation of sequestering of zinc ion|zinc ion transport	integral to membrane|late endosome|lysosomal membrane	cation transmembrane transporter activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.09e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00614)|READ - Rectum adenocarcinoma(331;0.0649)		GAACAGCTGTGAAGTCAACGC	0.617													7	18					0	0	0	0	A	26366380	A	A	26366380	2	1	276	1	0	0	0	0	0	0	0	1	14619	1281	45	2		2	SLC30A2	1	26366380	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	353405	26366380	222884241	26	49915											
RPS6KA1	6195	broad.mit.edu	37	chr1	26877918	26877918	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtccggaccaagatggagaGagacatcctggctgatgtaa	12	7	13	9	2	0	4	0	1	0	3	2	7	2	5	3	3	0	2	3	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:26877918G>A	uc001bmr.1	+	5	501	c.338G>A	c.(337-339)AGA>AAA	p.R113K	RPS6KA1_uc010ofe.1_Missense_Mutation_p.R21K|RPS6KA1_uc010off.1_Missense_Mutation_p.R97K|RPS6KA1_uc001bms.1_Missense_Mutation_p.R122K|RPS6KA1_uc009vsl.1_5'UTR	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	113	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		AAGATGGAGAGAGACATCCTG	0.567													10	24					0	0	0	0	A	26877918	A	A	26877918	3	1	276	1	0	0	0	0	1	0	0	0	13715	942	33	2	495	2	RPS6KA1	1	26877918	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	511538	26877918	222372703	27	49916											
ARID1A	8289	broad.mit.edu	37	chr1	27057646	27057647	+	Missense_Mutation	DNP	CC	TT	TT																															attttcctttcctacagattCctccttatggacaacaaggc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:27057646_27057647CC>TT	uc001bmv.1	+	3	1727_1728	c.1354_1355CC>TT	c.(1354-1356)CCT>TTT	p.P452F	ARID1A_uc001bmt.1_Missense_Mutation_p.P452F|ARID1A_uc001bmu.1_Missense_Mutation_p.P452F|ARID1A_uc001bmw.1_Missense_Mutation_p.P69F	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	452					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCTACAGATTCCTCCTTATGGA	0.47			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								35	124					0	0	0	0	TT	27057647	TT	TT	27057646	3	4	276	1	0	0	0	0	1	0	0	0	913	855	30	2	1364	2	ARID1A	1	27057646	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	179728	27057646	222192975	28	49917											
ZDHHC18	84243	broad.mit.edu	37	chr1	27176873	27176873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttctacgcgtttattctctCcctctcattcctgacggcct	4	16	5	16	3	3	1	1	1	3	0	7	1	5	1	3	1	1	1	3	1	2	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:27176873C>T	uc001bnb.2	+	4	823	c.728C>T	c.(727-729)TCC>TTC	p.S243F	ZDHHC18_uc010ofh.1_Missense_Mutation_p.S108F	NM_032283	NP_115659	Q9NUE0	ZDH18_HUMAN	zinc finger, DHHC-type containing 18	243	Helical; (Potential).					integral to membrane	zinc ion binding				0		all_cancers(24;5.82e-22)|all_epithelial(13;9.91e-20)|Colorectal(325;0.000147)|Breast(348;0.000706)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;5.71e-53)|Epithelial(14;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(117;1.53e-29)|Colorectal(126;1.9e-09)|COAD - Colon adenocarcinoma(152;4.2e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000548)|STAD - Stomach adenocarcinoma(196;0.00065)|KIRC - Kidney renal clear cell carcinoma(1967;0.000779)|GBM - Glioblastoma multiforme(114;0.0265)|READ - Rectum adenocarcinoma(331;0.0455)|Lung(427;0.163)|LUSC - Lung squamous cell carcinoma(448;0.237)		TTTATTCTCTCCCTCTCATTC	0.582													13	47					0	0	0	0	T	27176873	T	T	27176873	3	4	276	1	0	0	0	0	1	0	0	0	17675	855	30	2	742	2	ZDHHC18	1	27176873	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	119227	27176873	222073748	29	49918											
SFN	2810	broad.mit.edu	37	chr1	27190366	27190366	+	Silent	SNP	G	A	A																															gacagcaccctcatcatgcaGctgctgcgagacaacctgac																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:27190366G>A	uc001bnc.1	+	1	734	c.663G>A	c.(661-663)CAG>CAA	p.Q221Q	uc010ofi.1_RNA	NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	221					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		TCATCATGCAGCTGCTGCGAG	0.637													25	57					0	0	0	0	A	27190366	A	A	27190366	2	1	276	1	0	0	0	0	0	0	0	1	14224	962	34	4		4	SFN	1	27190366	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	13493	27190366	222060255	30	49919	112	2									
SFN	2810	broad.mit.edu	37	chr1	27190376	27190376	+	Missense_Mutation	SNP	G	A	A																															tcatcatgcagctgctgcgaGacaacctgacactgtggacg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:27190376G>A	uc001bnc.1	+	1	744	c.673G>A	c.(673-675)GAC>AAC	p.D225N	uc010ofi.1_RNA	NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	225					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		GCTGCTGCGAGACAACCTGAC	0.652													18	53					0	0	0	0	A	27190376	A	A	27190376	3	1	276	1	0	0	0	0	1	0	0	0	14224	942	33	2	675	2	SFN	1	27190376	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	10	27190376	222060245	31	49920	112	2									
NR0B2	8431	broad.mit.edu	37	chr1	27240329	27240329	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acataggcagcggctacgggGtcgggggacagccttgaggc	8	5	18	10	3	0	1	0	1	0	0	1	2	0	2	1	7	3	2	1	7	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:27240329G>A	uc001bnf.2	-	1	239	c.103C>T	c.(103-105)CCC>TCC	p.P35S		NM_021969	NP_068804	Q15466	NR0B2_HUMAN	short heterodimer partner	35					cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		CGGCTACGGGGTCGGGGGACA	0.662													6	41					0	0	0	0	A	27240329	A	A	27240329	3	1	276	1	0	0	0	0	1	0	0	0	10668	1261	44	4	678	4	NR0B2	1	27240329	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	49953	27240329	222010292	32	49921											
DCDC2B	149069	broad.mit.edu	37	chr1	32678090	32678090	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcctcacctctctctcccaGactctgcaccctagaggggc	6	9	7	19	0	4	2	1	0	3	2	7	2	5	2	4	2	1	1	4	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:32678090G>A	uc001bun.2	+	5	528	c.528_splice	c.e5-1	p.K176_splice		NM_001099434	NP_001092904	A2VCK2	DCD2B_HUMAN	doublecortin domain containing 2B						intracellular signal transduction						0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CTCTCTCCCAGACTCTGCACC	0.562													9	20					0	0	0	0	A	32678090	A	A	32678090	5	1	276	1	0	0	0	0	0	0	1	0	4303	956	33	2	545	2	DCDC2B	1	32678090	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5437761	32678090	216572531	33	49922											
LCK	3932	broad.mit.edu	37	chr1	32742008	32742008	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagccccagaagccgtggtgGgaggacgagtgggaggttcc	9	5	18	9	2	0	1	0	0	0	1	1	5	1	4	4	5	2	1	4	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:32742008G>A	uc001bux.2	+	8	840	c.702G>A	c.(700-702)TGG>TGA	p.W234*	LCK_uc001buy.2_Nonsense_Mutation_p.W234*|LCK_uc001buz.2_Nonsense_Mutation_p.W234*|LCK_uc010ohc.1_Nonsense_Mutation_p.W278*|LCK_uc001bva.2_Intron	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	234	Interaction with PTPRH.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	AGCCGTGGTGGGAGGACGAGT	0.662			T	TRB@	T-ALL								6	21					0	0	0	0	A	32742008	A	A	32742008	4	1	276	1	0	0	0	0	0	1	0	0	8716	1241	43	4	728	4	LCK	1	32742008	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	63918	32742008	216508613	34	49923											
CSMD2	114784	broad.mit.edu	37	chr1	34554764	34554764	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggctctcaactgtcccattgGgaccgtgcagttggaacgtg	7	10	13	11	2	1	0	1	0	1	0	3	2	2	2	2	3	3	3	2	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:34554764G>A	uc001bxn.1	-	2	127	c.98C>T	c.(97-99)CCC>CTC	p.P33L	CSMD2_uc001bxm.1_Missense_Mutation_p.P73L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	33	CUB 1.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGTCCCATTGGGACCGTGCAG	0.532													8	23					0	0	0	0	A	34554764	A	A	34554764	3	1	276	1	0	0	0	0	1	0	0	0	3962	1232	43	4	10637	4	CSMD2	1	34554764	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1812756	34554764	214695857	35	49924											
ZMYM6	9204	broad.mit.edu	37	chr1	35476584	35476584	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcttacaaccacttggccCtgagacaggggcaccgccga	9	5	13	14	2	0	1	0	1	0	1	0	3	0	1	4	4	2	2	4	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:35476584C>G	uc001byh.2	-	9	1344	c.1116G>C	c.(1114-1116)CAG>CAC	p.Q372H	ZMYM6_uc001byf.1_Missense_Mutation_p.Q372H|ZMYM6_uc010oht.1_Missense_Mutation_p.Q275H|ZMYM6_uc009vup.2_Missense_Mutation_p.Q178H|ZMYM6_uc009vuq.1_Missense_Mutation_p.Q372H|ZMYM6_uc009vur.1_Missense_Mutation_p.Q178H	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	372	MYM-type 5.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				CCACTTGGCCCTGAGACAGGG	0.493													15	37					0	0	0	0	G	35476584	G	G	35476584	3	3	276	1	0	0	0	0	1	0	0	0	17771	680	24	4	2893	4	ZMYM6	1	35476584	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	921820	35476584	213774037	36	49925											
COL8A2	1296	broad.mit.edu	37	chr1	36564591	36564591	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcctaagccagctggaccagGgaggccgggggggccggggg	6	2	22	11	2	0	0	0	0	0	0	0	2	0	2	5	8	2	1	5	8	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:36564591G>A	uc001bzv.1	-	2	698	c.691C>T	c.(691-693)CCT>TCT	p.P231S	COL8A2_uc001bzw.1_Missense_Mutation_p.P166S	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	231	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCTGGACCAGGGAGGCCGGGG	0.716													7	8					0	0	0	0	A	36564591	A	A	36564591	3	1	276	1	0	0	0	0	1	0	0	0	3721	1232	43	4	1424	4	COL8A2	1	36564591	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1088007	36564591	212686030	37	49926											
ZNF643	65243	broad.mit.edu	37	chr1	40929143	40929143	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttgctaaacatcagagaaTtcatactggagaaaaacctt	16	11	6	8	0	2	2	2	0	0	2	2	4	2	2	1	1	4	1	1	1	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:40929143T>A	uc001cfn.1	+	5	1784	c.1487T>A	c.(1486-1488)ATT>AAT	p.I496N	ZNF643_uc001cfl.1_Missense_Mutation_p.I394N|ZNF643_uc001cfm.1_Missense_Mutation_p.I362N	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	496	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			CATCAGAGAATTCATACTGGA	0.378													11	36					0	0	0	0	A	40929143	A	A	40929143	3	1	276	1	0	0	0	0	1	0	0	0	18126	1493	52	5	1505	5	ZNF643	1	40929143	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	4364552	40929143	208321478	38	49927											
SLFNL1	200172	broad.mit.edu	37	chr1	41483465	41483465	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagcggatgccctgcaccaGgccgctgtcctctactccca	6	7	10	18	2	1	0	0	0	1	0	3	1	3	1	5	2	4	3	5	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:41483465G>A	uc001cgm.1	-	3	1019	c.799C>T	c.(799-801)CTG>TTG	p.L267L	SLFNL1_uc009vwf.1_Silent_p.L267L|SLFNL1_uc001cgn.1_Silent_p.L208L|SLFNL1_uc009vwg.1_Silent_p.L267L	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	267	ATP (Potential).						ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				CCCTGCACCAGGCCGCTGTCC	0.662													5	31					0	0	0	0	A	41483465	A	A	41483465	2	1	276	1	0	0	0	0	0	0	0	1	14802	991	35	4		4	SLFNL1	1	41483465	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	554322	41483465	207767156	39	49928											
RIMKLA	284716	broad.mit.edu	37	chr1	42880386	42880386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catgtccttgctgccaaataGgcagactggaaagatggctg	11	9	12	9	0	0	2	0	0	0	2	1	3	1	3	2	3	2	3	2	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:42880386G>A	uc001chi.2	+	5	1055	c.917G>A	c.(916-918)AGG>AAG	p.R306K		NM_173642	NP_775913	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family	306					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CTGCCAAATAGGCAGACTGGA	0.532													24	59					0	0	0	0	A	42880386	A	A	42880386	3	1	276	1	0	0	0	0	1	0	0	0	13430	1000	35	4	935	4	RIMKLA	1	42880386	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1396921	42880386	206370235	40	49929											
WDR65	149465	broad.mit.edu	37	chr1	43675661	43675661	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttgttcatcccttcaacctCccaatgtcttttctctctcc	5	17	2	17	0	5	0	2	0	3	0	9	0	7	0	4	0	1	1	4	0	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:43675661C>T	uc001cip.1	+	11	2124	c.2003C>T	c.(2002-2004)TCC>TTC	p.S668F	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Intron|WDR65_uc001ciq.1_Missense_Mutation_p.S668F	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	Error:Variant_position_missing_in_Q96MR6_after_alignment										skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTTCAACCTCCCAATGTCTT	0.438													19	66					0	0	0	0	T	43675661	T	T	43675661	3	4	276	1	0	0	0	0	1	0	0	0	17384	855	30	2	2041	2	WDR65	1	43675661	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	795275	43675661	205574960	41	49930											
MED8	112950	broad.mit.edu	37	chr1	43853231	43853231	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggaatgatgacctggttacgGaacagcggtgttttttcatg	9	13	13	6	2	1	2	1	2	0	0	1	4	1	4	1	4	3	2	1	4	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:43853231G>A	uc001cjg.3	-	3	261	c.213C>T	c.(211-213)TTC>TTT	p.F71F	MED8_uc001cje.1_Silent_p.F71F|MED8_uc001cjf.3_5'UTR|C1orf84_uc001cjh.2_5'Flank|C1orf84_uc001cji.1_5'Flank|KIAA0467_uc009vws.1_5'Flank	NM_201542	NP_963836	Q96G25	MED8_HUMAN	mediator complex subunit 8 isoform 1	71					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCTGGTTACGGAACAGCGGTG	0.463													15	35					0	0	0	0	A	43853231	A	A	43853231	2	1	276	1	0	0	0	0	0	0	0	1	9506	1165	41	2		2	MED8	1	43853231	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	177570	43853231	205397390	42	49931											
KIAA0467	23334	broad.mit.edu	37	chr1	43897985	43897985	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggccatgttcttcttgaaGaccctgacagtggcttcttc	6	14	9	12	0	3	3	0	2	3	1	4	3	3	3	2	2	0	2	2	2	1	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:43897985G>A	uc001cjk.1	+	22	3082	c.2620G>A	c.(2620-2622)GAC>AAC	p.D874N		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1773						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCTTCTTGAAGACCCTGACAG	0.587													56	191					0	0	0	0	A	43897985	A	A	43897985	3	1	276	1	0	0	0	0	1	0	0	0	8217	942	33	2	2698	2	KIAA0467	1	43897985	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	44754	43897985	205352636	43	49932											
DPH2	1802	broad.mit.edu	37	chr1	44437418	44437418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagagagggccagagatgccCgcgtggtagggctgctggca	8	6	18	9	2	0	2	0	0	0	2	0	4	0	2	2	4	2	4	2	4	2	2	rs139555604	by1000genomes	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:44437418C>T	uc001ckz.2	+	4	1039	c.844C>T	c.(844-846)CGC>TGC	p.R282C	DPH2_uc001cla.2_Intron|DPH2_uc010okk.1_Missense_Mutation_p.R147C|DPH2_uc001clb.2_Missense_Mutation_p.R206C	NM_001384	NP_001375	Q9BQC3	DPH2_HUMAN	diphthamide biosynthesis protein 2 isoform a	282					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				CAGAGATGCCCGCGTGGTAGG	0.622													12	37					0	0	0	0	T	44437418	T	T	44437418	3	4	276	1	0	0	0	0	1	0	0	0	4742	652	23	1	858	1	DPH2	1	44437418	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	539433	44437418	204813203	44	49933											
PTCH2	8643	broad.mit.edu	37	chr1	45292235	45292235	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacaccagcaggatgcagacGgccagcaggaagcagcgccg	12	1	14	14	3	0	1	0	0	0	1	0	3	0	3	3	3	5	4	3	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:45292235G>C	uc010olf.1	-	18	2913	c.2901C>G	c.(2899-2901)GCC>GCG	p.A967A	PTCH2_uc010olg.1_Silent_p.A665A	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	967	Helical; (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					GGATGCAGACGGCCAGCAGGA	0.657									Basal_Cell_Nevus_syndrome				9	22					0	0	0	0	C	45292235	C	C	45292235	2	2	276	1	0	0	0	0	0	0	0	1	12793	1103	39	3		3	PTCH2	1	45292235	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	854817	45292235	203958386	45	49934											
CYP4A22	284541	broad.mit.edu	37	chr1	47614402	47614402	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcacgacttgtgttgaaatCcaaaaatggaatccacctgc	13	9	9	10	1	0	1	0	1	0	0	2	3	2	2	3	2	1	2	3	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:47614402C>T	uc001cqv.1	+	12	1544	c.1493C>T	c.(1492-1494)TCC>TTC	p.S498F		NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	498						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						GTGTTGAAATCCAAAAATGGA	0.582													17	63					0	0	0	0	T	47614402	T	T	47614402	3	4	276	1	0	0	0	0	1	0	0	0	4201	855	30	2	1539	2	CYP4A22	1	47614402	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2322167	47614402	201636219	46	49935											
TAL1	6886	broad.mit.edu	37	chr1	47685629	47685629	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggtccttgccagtcttggcCcgctgggtgccctcctcctc	1	11	12	17	1	1	0	0	0	1	0	5	0	4	0	6	3	2	1	6	3	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:47685629C>T	uc001cqx.2	-	4	1336	c.759G>A	c.(757-759)CGG>CGA	p.R253R	TAL1_uc009vyq.2_Missense_Mutation_p.G10E|TAL1_uc001cqy.2_Silent_p.R253R	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	253					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1						CAGTCTTGGCCCGCTGGGTGC	0.507			T	TRD@|SIL	lymphoblastic leukemia/biphasic								5	12					0	0	0	0	T	47685629	T	T	47685629	2	4	276	1	0	0	0	0	0	0	0	1	15607	610	22	4		4	TAL1	1	47685629	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	71227	47685629	201564992	47	49936											
ORC1L	4998	broad.mit.edu	37	chr1	52841197	52841197	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggggagtcaggcttctgctgGgagaactcacagatctctgt	8	10	14	9	0	4	2	2	0	2	2	5	4	4	3	0	4	2	2	0	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:52841197G>A	uc001ctt.2	-	15	2427	c.2208C>T	c.(2206-2208)TCC>TCT	p.S736S	ORC1L_uc010oni.1_Silent_p.S731S|ORC1L_uc001ctu.2_Silent_p.S736S|ORC1L_uc009vzd.2_Silent_p.S490S	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	736	Necessary and sufficient for ORC complex assembly.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						GCTTCTGCTGGGAGAACTCAC	0.517													18	51					0	0	0	0	A	52841197	A	A	52841197	2	1	276	1	0	0	0	0	0	0	0	1	11315	1219	43	4		4	ORC1L	1	52841197	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5155568	52841197	196409424	48	49937											
GPX7	2882	broad.mit.edu	37	chr1	53074034	53074035	+	Missense_Mutation	DNP	GG	AA	AA																															ccaactgtgtcagtggaggaGgtcagaccccagatcacagc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:53074034_53074035GG>AA	uc001cue.2	+	3	540_541	c.501_502GG>AA	c.(499-504)GAGGTC>GAAATC	p.V168I		NM_015696	NP_056511	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7 precursor	168					response to oxidative stress	extracellular region	glutathione peroxidase activity				0					Glutathione(DB00143)	CAGTGGAGGAGGTCAGACCCCA	0.574													12	67					0	0	0	0	AA	53074035	AA	AA	53074034	3	1	276	1	0	0	0	0	1	0	0	0	6784	991	35	4	511	4	GPX7	1	53074034	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	232837	53074034	196176587	49	49938											
TTC22	55001	broad.mit.edu	37	chr1	55252653	55252653	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgaagcagtctagagggtCggtccctgagtacccgcagt	8	7	14	12	3	1	2	0	1	1	1	3	3	2	2	3	2	2	3	3	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:55252653C>A	uc009vzt.1	-	4	940	c.835G>T	c.(835-837)GAC>TAC	p.D279Y	TTC22_uc001cxz.3_Missense_Mutation_p.D279Y	NM_001114108	NP_001107580	Q5TAA0	TTC22_HUMAN	tetratricopeptide repeat domain 22 isoform 1	279	TPR 4.						binding				0						TCTAGAGGGTCGGTCCCTGAG	0.642													6	8					0.00116845	0.00117961	1	0	A	55252653	A	A	55252653	3	1	276	1	0	0	0	0	1	0	0	0	16757	884	31	3	993	3	TTC22	1	55252653	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2178619	55252653	193997968	50	49939											
INADL	10207	broad.mit.edu	37	chr1	62503685	62503685	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcagatggccgttactccCtttccagtgccatcaagttc	9	12	7	13	1	2	1	2	0	0	1	5	1	4	1	4	1	2	2	4	1	3	3	rs35421196		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:62503685C>A	uc001dab.2	+	30	4110	c.3996C>A	c.(3994-3996)CCC>CCA	p.P1332P	INADL_uc009waf.1_Silent_p.P1332P|INADL_uc001daa.2_Silent_p.P1332P|INADL_uc001dad.3_Silent_p.P1029P|INADL_uc001dac.2_RNA|INADL_uc010oot.1_Silent_p.P116P|INADL_uc009wag.2_Silent_p.P116P|INADL_uc010oou.1_Silent_p.P5P	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1332					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CCGTTACTCCCTTTCCAGTGC	0.393													16	40					9.16793e-09	9.35232e-09	1	0	A	62503685	A	A	62503685	2	1	276	1	0	0	0	0	0	0	0	1	7770	668	24	4		4	INADL	1	62503685	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	7251032	62503685	186746936	51	49940											
RAVER2	55225	broad.mit.edu	37	chr1	65255158	65255158	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accctgccatgttgcaagttCttctacagccccagttatgt	8	13	7	13	0	2	0	0	0	2	0	2	0	2	0	4	0	4	4	4	0	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:65255158C>T	uc001dbs.1	+	5	1144	c.1066C>T	c.(1066-1068)CTT>TTT	p.L356F	RAVER2_uc001dbt.1_Missense_Mutation_p.L235F|RAVER2_uc010opb.1_Missense_Mutation_p.L235F	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	356						cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						GTTGCAAGTTCTTCTACAGCC	0.368													18	41					0	0	0	0	T	65255158	T	T	65255158	3	4	276	1	0	0	0	0	1	0	0	0	13160	913	32	2	1084	2	RAVER2	1	65255158	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2751473	65255158	183995463	52	49941											
LEPR	3953	broad.mit.edu	37	chr1	66031281	66031281	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaattctgtgtggttttgttAcattggggtaagttatttgc	8	19	11	3	0	1	0	0	0	1	0	1	0	1	0	0	3	2	4	0	3	4	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:66031281A>T	uc001dci.2	+	3	235	c.33A>T	c.(31-33)TTA>TTT	p.L11F	LEPR_uc001dcg.2_Missense_Mutation_p.L11F|LEPR_uc001dch.2_Missense_Mutation_p.L11F|LEPR_uc009waq.2_Missense_Mutation_p.L11F|LEPR_uc001dcj.2_Missense_Mutation_p.L11F|LEPR_uc001dck.2_Missense_Mutation_p.L11F	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	11					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TGGTTTTGTTACATTGGGGTA	0.323													10	41					0	0	0	0	T	66031281	T	T	66031281	3	4	276	1	0	0	0	0	1	0	0	0	8768	388	14	5	35	5	LEPR	1	66031281	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	776123	66031281	183219340	53	49942											
C1orf173	127254	broad.mit.edu	37	chr1	75037433	75037433	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgtgtgtttccttctccttCcatgtccccgtccccttccg	1	17	6	17	2	1	0	0	0	1	0	7	0	6	0	8	0	0	1	8	0	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:75037433C>T	uc001dgg.2	-	14	4180	c.3961G>A	c.(3961-3963)GAA>AAA	p.E1321K		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1321	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTTCTCCTTCCATGTCCCCG	0.562													22	79					0	0	0	0	T	75037433	T	T	75037433	3	4	276	1	0	0	0	0	1	0	0	0	2023	864	30	2	635	2	C1orf173	1	75037433	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	9006152	75037433	174213188	54	49943											
C1orf173	127254	broad.mit.edu	37	chr1	75038398	75038398	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccggcttgcctctgcctctCctgtgaaggggctcaagcgt	4	11	12	14	2	3	1	1	1	2	0	5	1	4	1	4	3	3	2	4	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:75038398C>T	uc001dgg.2	-	14	3215	c.2996G>A	c.(2995-2997)GGA>GAA	p.G999E		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	999	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTCTGCCTCTCCTGTGAAGGG	0.537													17	40					0	0	0	0	T	75038398	T	T	75038398	3	4	276	1	0	0	0	0	1	0	0	0	2023	855	30	2	1600	2	C1orf173	1	75038398	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	965	75038398	174212223	55	49944											
C1orf173	127254	broad.mit.edu	37	chr1	75072544	75072544	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcttttctttcctagatttCggcaaagacggttttttgtc	6	19	7	9	2	2	2	0	0	2	2	5	2	3	2	1	2	0	2	1	2	2	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:75072544C>T	uc001dgg.2	-	10	1449	c.1230G>A	c.(1228-1230)CCG>CCA	p.P410P	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.P204P	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	410										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCCTAGATTTCGGCAAAGACG	0.413													25	84					0	0	0	0	T	75072544	T	T	75072544	2	4	276	1	0	0	0	0	0	0	0	1	2023	871	31	1		1	C1orf173	1	75072544	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	34146	75072544	174178077	56	49945											
PIGK	10026	broad.mit.edu	37	chr1	77627083	77627083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggactccaattgcaggatcaGgttgatgctatggaaagggg	11	9	15	6	0	1	1	1	1	0	0	2	4	2	4	1	6	2	3	1	6	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:77627083G>A	uc001dhk.2	-	8	755	c.710C>T	c.(709-711)CCT>CTT	p.P237L	PIGK_uc010orj.1_Missense_Mutation_p.P161L|PIGK_uc009wbx.2_Missense_Mutation_p.P143L|PIGK_uc001dhl.1_Missense_Mutation_p.P237L	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	237	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						TGCAGGATCAGGTTGATGCTA	0.313													8	25					0	0	0	0	A	77627083	A	A	77627083	3	1	276	1	0	0	0	0	1	0	0	0	11945	1000	35	4	493	4	PIGK	1	77627083	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2554539	77627083	171623538	57	49946											
LPHN2	23266	broad.mit.edu	37	chr1	82408872	82408872	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacatataaacttccaaatcGagtagatggtactggatttg	15	12	8	6	1	0	1	0	0	0	1	2	3	1	2	1	2	3	2	1	2	7	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:82408872G>A	uc001dit.3	+	6	798	c.617G>A	c.(616-618)CGA>CAA	p.R206Q	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.R206Q|LPHN2_uc001div.2_Missense_Mutation_p.R206Q|LPHN2_uc009wcd.2_Missense_Mutation_p.R206Q	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	206	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CTTCCAAATCGAGTAGATGGT	0.363													20	28					0	0	0	0	A	82408872	A	A	82408872	3	1	276	1	0	0	0	0	1	0	0	0	8966	1058	37	1	631	1	LPHN2	1	82408872	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4781789	82408872	166841749	58	49947											
MCOLN3	55283	broad.mit.edu	37	chr1	85486956	85486956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agagaccatgttcagagaacGaaactggaaaaagaaaagag	21	4	11	5	1	1	4	1	0	0	4	1	8	1	5	1	1	2	1	1	1	6	1	rs139077973		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:85486956G>A	uc001dkp.2	-	12	1417	c.1324C>T	c.(1324-1326)CGT>TGT	p.R442C	MCOLN3_uc001dko.2_Missense_Mutation_p.R61C|MCOLN3_uc001dkq.2_Missense_Mutation_p.R386C	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	442						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		TTCAGAGAACGAAACTGGAAA	0.368													15	49					0	0	0	0	A	85486956	A	A	85486956	3	1	276	1	0	0	0	0	1	0	0	0	9450	1058	37	1	345	1	MCOLN3	1	85486956	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3078084	85486956	163763665	59	49948											
COL24A1	255631	broad.mit.edu	37	chr1	86315049	86315049	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattaccttttttcctggaCgacctctttgccctggaatt	8	16	6	11	1	1	0	0	0	1	0	2	3	2	2	4	2	2	0	4	2	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:86315049C>T	uc001dlj.2	-	38	3383	c.3341G>A	c.(3340-3342)CGT>CAT	p.R1114H	COL24A1_uc001dli.2_Missense_Mutation_p.R250H|COL24A1_uc010osd.1_Missense_Mutation_p.R414H|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1114					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTTTCCTGGACGACCTCTTTG	0.348													21	83					0	0	0	0	T	86315049	T	T	86315049	3	4	276	1	0	0	0	0	1	0	0	0	3698	536	19	1	1895	1	COL24A1	1	86315049	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	828093	86315049	162935572	60	49949											
CLCA1	1179	broad.mit.edu	37	chr1	86939149	86939149	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcttgaagctacaggaaagcGattttatttcaaaaatgttg	14	13	9	5	1	1	1	1	1	0	0	1	3	1	2	0	1	3	3	0	1	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:86939149G>A	uc001dlt.2	+	2	341	c.212G>A	c.(211-213)CGA>CAA	p.R71Q	CLCA1_uc001dls.1_Intron	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	71					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		ACAGGAAAGCGATTTTATTTC	0.358													17	31					0	0	0	0	A	86939149	A	A	86939149	3	1	276	1	0	0	0	0	1	0	0	0	3472	1058	37	1	218	1	CLCA1	1	86939149	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	624100	86939149	162311472	61	49950											
RBMXL1	494115	broad.mit.edu	37	chr1	89448465	89448465	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccccctttctacagaaggggGaagccctctttcttgtctgc	6	12	9	14	0	4	1	0	0	4	1	4	2	4	2	3	2	3	0	3	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:89448465G>A	uc009wcx.2	-	3	1761	c.1045C>T	c.(1045-1047)CCC>TCC	p.P349S	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Missense_Mutation_p.P349S	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	349	Ser-rich.						nucleotide binding|RNA binding				0						ACAGAAGGGGGAAGCCCTCTT	0.537													47	133					0	0	0	0	A	89448465	A	A	89448465	3	1	276	1	0	0	0	0	1	0	0	0	13218	1174	41	2	131	2	RBMXL1	1	89448465	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2509316	89448465	159802156	62	49951											
TGFBR3	7049	broad.mit.edu	37	chr1	92187698	92187698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccaaagccaatactgttagGagcctgaagatatagcaaaa	17	8	8	8	0	0	2	0	1	0	1	1	3	1	3	3	1	4	2	3	1	9	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:92187698G>A	uc001doh.2	-	8	1355	c.889C>T	c.(889-891)CCT>TCT	p.P297S	TGFBR3_uc009wde.2_Missense_Mutation_p.P75S|TGFBR3_uc010osy.1_Missense_Mutation_p.P255S|TGFBR3_uc001doi.2_Missense_Mutation_p.P297S|TGFBR3_uc001doj.2_Missense_Mutation_p.P297S	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	297	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		ATACTGTTAGGAGCCTGAAGA	0.308													11	26					0	0	0	0	A	92187698	A	A	92187698	3	1	276	1	0	0	0	0	1	0	0	0	15889	1174	41	2	1706	2	TGFBR3	1	92187698	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2739233	92187698	157062923	63	49952											
C1orf146	388649	broad.mit.edu	37	chr1	92709803	92709803	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttttattaatggatactaagGaatgtcttctgtcaactgaa	13	16	7	5	0	3	1	1	1	2	0	3	3	3	3	0	2	2	0	0	2	7	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:92709803G>A	uc001doq.2	+	4	262	c.190G>A	c.(190-192)GAA>AAA	p.E64K	C1orf146_uc010ote.1_Missense_Mutation_p.E5K	NM_001012425	NP_001012425	Q5VVC0	CA146_HUMAN	hypothetical protein LOC388649	64										ovary(1)	1		all_lung(203;0.00528)|Lung NSC(277;0.0193)		all cancers(265;0.00846)|Epithelial(280;0.0952)		GGATACTAAGGAATGTCTTCT	0.299													13	35					0	0	0	0	A	92709803	A	A	92709803	3	1	276	1	0	0	0	0	1	0	0	0	2012	1175	41	2	200	2	C1orf146	1	92709803	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	522105	92709803	156540818	64	49953											
ABCA4	24	broad.mit.edu	37	chr1	94487499	94487499	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctttcctccaatggaaattCctccatacctgacaaggaaa	13	10	6	12	0	0	1	0	1	0	0	4	3	4	3	5	2	1	1	5	2	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:94487499C>T	uc001dqh.2	-	33	4780	c.4676G>A	c.(4675-4677)GGA>GAA	p.G1559E		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1559	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.G1559*(1)		ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AATGGAAATTCCTCCATACCT	0.512													8	36					0	0	0	0	T	94487499	T	T	94487499	3	4	276	1	0	0	0	0	1	0	0	0	34	855	30	2	2217	2	ABCA4	1	94487499	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1777696	94487499	154763122	65	49954											
FRRS1	391059	broad.mit.edu	37	chr1	100212952	100212952	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcagcattacgcgcttctagGagaaagcctttaaatggatg	12	11	10	8	2	2	1	1	0	1	1	2	3	2	2	1	2	3	2	1	2	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:100212952G>A	uc001dsh.1	-	4	833	c.231C>T	c.(229-231)CTC>CTT	p.L77L		NM_001013660	NP_001013682	Q6ZNA5	FRRS1_HUMAN	stromal cell derived factor receptor 2 homolog	77	Reelin.				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		GCGCTTCTAGGAGAAAGCCTT	0.388													39	99					0	0	0	0	A	100212952	A	A	100212952	2	1	276	1	0	0	0	0	0	0	0	1	6094	1161	41	2		2	FRRS1	1	100212952	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5725453	100212952	149037669	66	49955											
DBT	1629	broad.mit.edu	37	chr1	100715333	100715333	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caaacgtgcttaccagcttcCccgcattcctgctccaggtt	7	11	7	16	2	0	0	0	0	0	0	3	0	3	0	5	1	5	5	5	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:100715333C>T	uc001dta.2	-	1	77	c.44G>A	c.(43-45)GGG>GAG	p.G15E	DBT_uc010oug.1_5'UTR	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	15					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TACCAGCTTCCCCGCATTCCT	0.582													9	41					0	0	0	0	T	100715333	T	T	100715333	3	4	276	1	0	0	0	0	1	0	0	0	4275	623	22	4	1448	4	DBT	1	100715333	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	502381	100715333	148535288	67	49956											
COL11A1	1301	broad.mit.edu	37	chr1	103412481	103412481	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtaaaccaattgggccagctGtacctgctgacccacgttct	9	10	9	13	1	1	1	0	1	1	0	1	1	1	1	4	1	4	5	4	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:103412481G>A	uc001dul.2	-	42	3518	c.3200C>T	c.(3199-3201)ACA>ATA	p.T1067I	COL11A1_uc001duk.2_Missense_Mutation_p.T263I|COL11A1_uc001dum.2_Missense_Mutation_p.T1079I|COL11A1_uc001dun.2_Missense_Mutation_p.T1028I|COL11A1_uc009weh.2_Missense_Mutation_p.T951I	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1067	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGGGCCAGCTGTACCTGCTGA	0.458													3	19					0	0	0	0	A	103412481	A	A	103412481	3	1	276	1	0	0	0	0	1	0	0	0	3682	1377	48	4	2324	4	COL11A1	1	103412481	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2697148	103412481	145838140	68	49957											
COL11A1	1301	broad.mit.edu	37	chr1	103427456	103427456	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggccctggggaccttcccctCctttcagtccaggtgcaccc	4	9	10	18	0	1	0	1	0	0	0	4	1	4	1	7	4	1	1	7	4	0	2	rs149000575		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:103427456C>T	uc001dul.2	-	41	3452	c.3134G>A	c.(3133-3135)GGA>GAA	p.G1045E	COL11A1_uc001duk.2_Missense_Mutation_p.G241E|COL11A1_uc001dum.2_Missense_Mutation_p.G1057E|COL11A1_uc001dun.2_Missense_Mutation_p.G1006E|COL11A1_uc009weh.2_Missense_Mutation_p.G929E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1045	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACCTTCCCCTCCTTTCAGTCC	0.388													5	36					0	0	0	0	T	103427456	T	T	103427456	3	4	276	1	0	0	0	0	1	0	0	0	3682	855	30	2	2394	2	COL11A1	1	103427456	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	14975	103427456	145823165	69	49958											
COL11A1	1301	broad.mit.edu	37	chr1	103548459	103548459	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctttctgtttgtgcaaaatCccgttgtttttgatattccc	6	20	6	9	1	2	1	0	1	2	0	4	1	4	1	2	0	1	4	2	0	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:103548459C>T	uc001dul.2	-	2	494	c.176G>A	c.(175-177)GGA>GAA	p.G59E	COL11A1_uc001dum.2_Missense_Mutation_p.G59E|COL11A1_uc001dun.2_Missense_Mutation_p.G59E|COL11A1_uc009weh.2_Missense_Mutation_p.G59E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	59	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGTGCAAAATCCCGTTGTTTT	0.373													20	48					0	0	0	0	T	103548459	T	T	103548459	3	4	276	1	0	0	0	0	1	0	0	0	3682	855	30	2	5665	2	COL11A1	1	103548459	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	121003	103548459	145702162	70	49959											
CELSR2	1952	broad.mit.edu	37	chr1	109793177	109793177	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcccccgggctcagggcagGggaaaggtcaccagaagagt	10	3	17	11	1	2	2	2	0	0	2	2	3	2	3	3	6	0	2	3	6	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:109793177G>A	uc001dxa.3	+	1	537	c.476G>A	c.(475-477)GGG>GAG	p.G159E		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	159	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTCAGGGCAGGGGAAAGGTCA	0.642													7	27					0	0	0	0	A	109793177	A	A	109793177	3	1	276	1	0	0	0	0	1	0	0	0	3237	1232	43	4	478	4	CELSR2	1	109793177	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6244718	109793177	139457444	71	49960											
AMIGO1	57463	broad.mit.edu	37	chr1	110051361	110051361	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgctgtgtaactgggcaaGgaatggggcacattgggcag	10	8	17	6	0	0	0	0	0	0	0	0	1	0	1	0	5	2	5	0	5	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:110051361G>A	uc001dxx.3	-	2	556	c.174C>T	c.(172-174)TCC>TCT	p.S58S		NM_020703	NP_065754	Q86WK6	AMGO1_HUMAN	AMIGO protein precursor	58	LRRNT.|Extracellular (Potential).				axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				ovary(1)|breast(1)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		AACTGGGCAAGGAATGGGGCA	0.642													8	30					0	0	0	0	A	110051361	A	A	110051361	2	1	276	1	0	0	0	0	0	0	0	1	575	987	35	4		4	AMIGO1	1	110051361	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	258184	110051361	139199260	72	49961											
FAM40A	85369	broad.mit.edu	37	chr1	110590435	110590435	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggctgcagcacccacctcAaaagccaaaacagactcaat	15	6	6	14	0	2	1	2	0	0	1	2	1	2	1	3	1	4	3	3	1	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:110590435A>T	uc001dza.1	+	15	1624	c.1605A>T	c.(1603-1605)TCA>TCT	p.S535S	FAM40A_uc001dyz.1_Silent_p.S440S|FAM40A_uc009wfp.1_Silent_p.S359S	NM_033088	NP_149079	Q5VSL9	FA40A_HUMAN	hypothetical protein LOC85369	535						nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)		CACCCACCTCAAAAGCCAAAA	0.502													2	2					0	0	0	0	T	110590435	T	T	110590435	2	4	276	1	0	0	0	0	0	0	0	1	5592	117	5	5		5	FAM40A	1	110590435	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	539074	110590435	138660186	73	49962											
KCNC4	3749	broad.mit.edu	37	chr1	110754452	110754452	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctacgtgctcaactactacCgcaccggcaagctgcactgc	9	7	8	17	3	1	0	1	0	0	0	1	0	1	0	3	1	8	5	3	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:110754452C>T	uc001dzh.2	+	1	388	c.331C>T	c.(331-333)CGC>TGC	p.R111C	KCNC4_uc001dzf.2_Missense_Mutation_p.R111C|KCNC4_uc009wfr.2_Missense_Mutation_p.R111C|KCNC4_uc001dzg.2_Missense_Mutation_p.R111C|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	111	Cytoplasmic (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CAACTACTACCGCACCGGCAA	0.493													13	31					0	0	0	0	T	110754452	T	T	110754452	3	4	276	1	0	0	0	0	1	0	0	0	8056	652	23	1	333	1	KCNC4	1	110754452	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	164017	110754452	138496169	74	49963											
KCNA2	3737	broad.mit.edu	37	chr1	111147020	111147020	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccttgatgtagccttcatCttcccgaaacatctccatcg	8	13	5	15	2	3	1	1	1	2	0	7	2	5	1	4	0	2	1	4	0	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:111147020C>T	uc001dzu.2	-	2	881	c.385G>A	c.(385-387)GAT>AAT	p.D129N	KCNA2_uc009wfv.1_Missense_Mutation_p.D129N|KCNA2_uc009wfw.2_Missense_Mutation_p.D129N	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	129						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		TAGCCTTCATCTTCCCGAAAC	0.488													11	37					0	0	0	0	T	111147020	T	T	111147020	3	4	276	1	0	0	0	0	1	0	0	0	8042	913	32	2	1118	2	KCNA2	1	111147020	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	392568	111147020	138103601	75	49964											
KCNA3	3738	broad.mit.edu	37	chr1	111216580	111216580	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagctggaggctcctgcgcgGgaccccgacgtgctgttgcc	5	7	15	14	4	0	0	0	0	0	0	1	3	1	2	4	3	4	4	4	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:111216580G>A	uc001dzv.1	-	1	1076	c.852C>T	c.(850-852)TCC>TCT	p.S284S		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	284						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTCCTGCGCGGGACCCCGACG	0.627													11	54					0	0	0	0	A	111216580	A	A	111216580	2	1	276	1	0	0	0	0	0	0	0	1	8043	1219	43	4		4	KCNA3	1	111216580	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	69560	111216580	138034041	76	49965											
CHIA	27159	broad.mit.edu	37	chr1	111861776	111861776	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaaaaatggagccactcaggGatgggatgcccctcaggaag	13	5	14	9	0	2	0	2	0	0	0	2	5	2	4	3	4	2	0	3	4	3	0	rs139812869	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:111861776G>A	uc001eas.2	+	10	1053	c.950G>A	c.(949-951)GGA>GAA	p.G317E	CHIA_uc001ear.2_Missense_Mutation_p.G209E|CHIA_uc001eaq.2_Missense_Mutation_p.G209E|CHIA_uc009wgc.2_Missense_Mutation_p.G209E|CHIA_uc001eat.2_Missense_Mutation_p.G156E|CHIA_uc001eav.2_Missense_Mutation_p.G156E|CHIA_uc001eau.2_Missense_Mutation_p.G156E|CHIA_uc009wgd.2_Missense_Mutation_p.G156E	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	317					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		GCCACTCAGGGATGGGATGCC	0.408													10	42					0	0	0	0	A	111861776	A	A	111861776	3	1	276	1	0	0	0	0	1	0	0	0	3357	1174	41	2	984	2	CHIA	1	111861776	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	645196	111861776	137388845	77	49966											
MOV10	4343	broad.mit.edu	37	chr1	113239079	113239079	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gttggtctcggcccagtttcCcattgatcacttcacacaca	8	12	7	14	1	3	1	2	1	1	0	5	1	4	1	2	2	0	2	2	2	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:113239079C>T	uc001eck.2	+	13	2174	c.1904C>T	c.(1903-1905)CCC>CTC	p.P635L	MOV10_uc001ecl.2_Intron|MOV10_uc001ecn.2_Missense_Mutation_p.P635L|MOV10_uc001ecm.2_Missense_Mutation_p.P575L|MOV10_uc009wgj.1_3'UTR	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	635					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		GCCCAGTTTCCCATTGATCAC	0.572													22	79					0	0	0	0	T	113239079	T	T	113239079	3	4	276	1	0	0	0	0	1	0	0	0	9771	623	22	4	1950	4	MOV10	1	113239079	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1377303	113239079	136011542	78	49967											
CSDE1	7812	broad.mit.edu	37	chr1	115280598	115280598	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actaacttgtccattcattcGttcttcagggaggatttctt	8	17	7	9	1	4	0	2	0	2	0	6	2	5	2	1	2	1	1	1	2	1	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:115280598G>C	uc001efk.2	-	4	761	c.295C>G	c.(295-297)CGA>GGA	p.R99G	CSDE1_uc001efi.2_Missense_Mutation_p.R145G|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.R99G|CSDE1_uc001efm.2_Missense_Mutation_p.R145G|CSDE1_uc009wgv.2_Missense_Mutation_p.R99G|CSDE1_uc001efn.2_Missense_Mutation_p.R99G	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	99					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCATTCATTCGTTCTTCAGGG	0.398													11	54					0	0	0	0	C	115280598	C	C	115280598	3	2	276	1	0	0	0	0	1	0	0	0	3946	1153	40	3	2169	3	CSDE1	1	115280598	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2041519	115280598	133970023	79	49968											
SYCP1	6847	broad.mit.edu	37	chr1	115456614	115456614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaataacaaaaagcaagaaGaaaggatgttgaaacaaata	25	5	8	3	0	0	4	0	1	0	3	0	5	0	5	0	1	3	2	0	1	10	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:115456614G>A	uc001efr.2	+	20	1875	c.1666G>A	c.(1666-1668)GAA>AAA	p.E556K	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.E556K|SYCP1_uc009wgw.2_Missense_Mutation_p.E556K	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	556	Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAGCAAGAAGAAAGGATGTT	0.244													9	28					0	0	0	0	A	115456614	A	A	115456614	3	1	276	1	0	0	0	0	1	0	0	0	15497	943	33	2	1740	2	SYCP1	1	115456614	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	176016	115456614	133794007	80	49969											
IGSF3	3321	broad.mit.edu	37	chr1	117122029	117122029	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcacttgtatctagaacacGgatgccgatgggggctgact	9	10	12	10	2	2	2	1	1	1	1	2	4	2	3	1	3	2	2	1	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:117122029G>C	uc001egr.1	-	10	4024	c.3319C>G	c.(3319-3321)CGT>GGT	p.R1107G	IGSF3_uc001egq.1_Missense_Mutation_p.R1127G	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	1107	Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		TCTAGAACACGGATGCCGATG	0.507													14	61					0	0	0	0	C	117122029	C	C	117122029	3	2	276	1	0	0	0	0	1	0	0	0	7640	1116	39	3	273	3	IGSF3	1	117122029	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1665415	117122029	132128592	81	49970											
VTCN1	79679	broad.mit.edu	37	chr1	117699529	117699529	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggcgacagtagtgactgTgatggagtgtctccctgcag	8	10	15	8	1	1	3	0	3	1	0	2	5	1	4	1	2	1	2	1	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:117699529T>A	uc001ehb.2	-	3	184	c.112A>T	c.(112-114)ACA>TCA	p.T38S	VTCN1_uc001ehc.2_5'UTR|VTCN1_uc009whf.1_Intron	NM_024626	NP_078902	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation	38	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane					0	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		GTAGTGACTGTGATGGAGTGT	0.473													15	38					0	0	0	0	A	117699529	A	A	117699529	3	1	276	1	0	0	0	0	1	0	0	0	17302	1696	59	5	748	5	VTCN1	1	117699529	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	577500	117699529	131551092	82	49971											
TBX15	6913	broad.mit.edu	37	chr1	119427862	119427863	+	Missense_Mutation	DNP	GG	AA	AA																															tgaggcatgaaggtttcagaGggctgagtggctgaagtggt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:119427862_119427863GG>AA	uc001ehl.1	-	8	1298_1299	c.983_984CC>TT	c.(982-984)CCC>CTT	p.P328L	TBX15_uc009whj.1_Missense_Mutation_p.P152L	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	434						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		AGGTTTCAGAGGGCTGAGTGGC	0.574													11	32					0	0	0	0	AA	119427863	AA	AA	119427862	3	1	276	1	0	0	0	0	1	0	0	0	15718	987	35	4	510	4	TBX15	1	119427862	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	1728333	119427862	129822759	83	49972											
TBX15	6913	broad.mit.edu	37	chr1	119466122	119466122	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggaaagttgaacgttttcacCccatccccaacaggaacagg	13	7	9	12	1	1	1	1	1	0	0	2	3	2	3	4	3	3	2	4	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:119466122C>T	uc001ehl.1	-	5	795	c.480G>A	c.(478-480)GGG>GGA	p.G160G		NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	266	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		ACGTTTTCACCCCATCCCCAA	0.488													14	38					0	0	0	0	T	119466122	T	T	119466122	2	4	276	1	0	0	0	0	0	0	0	1	15718	610	22	4		4	TBX15	1	119466122	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	38260	119466122	129784499	84	49973											
WARS2	10352	broad.mit.edu	37	chr1	119575733	119575733	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgagcagtgttcatgcccGcgctgcggcgcaccacttcc	6	7	12	16	5	1	0	1	0	0	0	2	1	2	0	3	1	4	4	3	1	0	2	rs140469836		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:119575733G>A	uc001ehn.2	-	6	912	c.884C>T	c.(883-885)GCG>GTG	p.A295V	WARS2_uc010oxf.1_Missense_Mutation_p.A201V|WARS2_uc001ehm.2_3'UTR|WARS2_uc010oxg.1_Missense_Mutation_p.A238V|WARS2_uc010oxh.1_3'UTR	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	295					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	GTTCATGCCCGCGCTGCGGCG	0.597													16	48					0	0	0	0	A	119575733	A	A	119575733	3	1	276	1	0	0	0	0	1	0	0	0	17318	1087	38	1	202	1	WARS2	1	119575733	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	109611	119575733	129674888	85	49974											
PPIAL4G	644591	broad.mit.edu	37	chr1	143767641	143767641	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttgtcaccggtgccattagGgtgtgtgaagtcaccaccct	7	11	11	12	1	2	1	2	1	0	0	2	1	2	1	4	2	1	0	4	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:143767641G>A	uc001ejt.2	-	1	241	c.208C>T	c.(208-210)CCT>TCT	p.P70S		NM_001123068	NP_001116540	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like	70	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity				0						GTGCCATTAGGGTGTGTGAAG	0.468													38	253					0	0	0	0	A	143767641	A	A	143767641	3	1	276	1	0	0	0	0	1	0	0	0	12378	1232	43	4	290	4	PPIAL4G	1	143767641	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	24191908	143767641	105482980	86	49975											
PDE4DIP	9659	broad.mit.edu	37	chr1	145075855	145075855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcaggacccgctgtctgtgCccttcatggatttcctgggc	5	11	12	13	1	2	0	1	0	1	0	3	2	3	2	3	3	2	2	3	3	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:145075855C>T	uc001emh.2	-	1	225	c.8G>A	c.(7-9)GGC>GAC	p.G3D	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Missense_Mutation_p.G3D|PDE4DIP_uc001emk.2_Missense_Mutation_p.G3D	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:Variant_position_missing_in_Q5VU43_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTGTCTGTGCCCTTCATGGA	0.672			T	PDGFRB	MPD								5	58					0	0	0	0	T	145075855	T	T	145075855	3	4	276	1	0	0	0	0	1	0	0	0	11697	739	26	4	8804	4	PDE4DIP	1	145075855	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1308214	145075855	104174766	87	49976											
ACP6	51205	broad.mit.edu	37	chr1	147131114	147131114	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagcccagccagcaaacaacGggtggactccagattccgaa	14	4	10	13	2	0	1	0	0	0	1	2	3	2	2	4	2	5	1	4	2	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:147131114G>A	uc001epr.2	-	4	984	c.520C>T	c.(520-522)CGT>TGT	p.R174C	ACP6_uc009wjj.1_Missense_Mutation_p.R131C	NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	174					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					AGCAAACAACGGGTGGACTCC	0.423													24	112					0	0	0	0	A	147131114	A	A	147131114	3	1	276	1	0	0	0	0	1	0	0	0	165	1116	39	1	794	1	ACP6	1	147131114	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2055259	147131114	102119507	88	49977											
PRPF3	9129	broad.mit.edu	37	chr1	150300844	150300844	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtaaagaagcgacgaataccCcgttttgaggaggtggaaga	14	7	14	6	3	0	3	0	1	0	2	0	7	0	5	2	3	2	2	2	3	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:150300844C>T	uc001eum.3	+	4	504	c.342C>T	c.(340-342)CCC>CCT	p.P114P	PRPF3_uc009wlo.2_Silent_p.P114P|PRPF3_uc009wlp.2_RNA|PRPF3_uc010pca.1_Silent_p.P73P|PRPF3_uc010pcb.1_Intron	NM_004698	NP_004689	O43395	PRPF3_HUMAN	PRP3 pre-mRNA processing factor 3 homolog	114					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			ovary(1)	1	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		GACGAATACCCCGTTTTGAGG	0.498													25	134					0	0	0	0	T	150300844	T	T	150300844	2	4	276	1	0	0	0	0	0	0	0	1	12627	610	22	4		4	PRPF3	1	150300844	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3169730	150300844	98949777	89	49978											
ADAMTSL4	54507	broad.mit.edu	37	chr1	150527914	150527914	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgtcccttagtccagggctCccagcgctgtgaactgaact	7	10	10	14	1	0	2	0	2	0	0	3	2	3	2	3	1	3	2	3	1	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:150527914C>T	uc001eux.2	+	8	1480	c.1244C>T	c.(1243-1245)TCC>TTC	p.S415F	ADAMTSL4_uc001euw.2_Missense_Mutation_p.S415F|ADAMTSL4_uc009wlw.2_Missense_Mutation_p.S438F|ADAMTSL4_uc010pcg.1_Missense_Mutation_p.S438F|ADAMTSL4_uc009wlx.2_5'Flank	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	415					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GTCCAGGGCTCCCAGCGCTGT	0.627													9	7					0	0	0	0	T	150527914	T	T	150527914	3	4	276	1	0	0	0	0	1	0	0	0	277	855	30	2	1266	2	ADAMTSL4	1	150527914	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	227070	150527914	98722707	90	49979											
TNFAIP8L2	79626	broad.mit.edu	37	chr1	151131544	151131545	+	Missense_Mutation	DNP	GG	AA	AA																															tggcctgctgaccgagtgccGggatgtgctgctagagttgg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:151131544_151131545GG>AA	uc001ewx.2	+	2	497_498	c.371_372GG>AA	c.(370-372)CGG>CAA	p.R124Q		NM_024575	NP_078851	Q6P589	TP8L2_HUMAN	tumor necrosis factor, alpha-induced protein	124					innate immune response						0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACCGAGTGCCGGGATGTGCTGC	0.604													11	38					0	0	0	0	AA	151131545	AA	AA	151131544	3	1	276	1	0	0	0	0	1	0	0	0	16344	1116	39	1	373	1	TNFAIP8L2	1	151131544	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	603630	151131544	98119077	91	49980											
RFX5	5993	broad.mit.edu	37	chr1	151316355	151316355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttacttctgggcccatttCtggctgaagtggggaaggac	7	11	15	8	0	2	1	0	1	2	0	2	3	2	3	1	6	1	2	1	6	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:151316355C>T	uc001exv.1	-	9	773	c.559G>A	c.(559-561)GAA>AAA	p.E187K	RFX5_uc001exw.1_Missense_Mutation_p.E187K|RFX5_uc009wmr.1_Missense_Mutation_p.E187K|RFX5_uc010pcx.1_Missense_Mutation_p.E147K	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	187						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGGCCCATTTCTGGCTGAAGT	0.532													10	41					0	0	0	0	T	151316355	T	T	151316355	3	4	276	1	0	0	0	0	1	0	0	0	13331	922	32	2	1303	2	RFX5	1	151316355	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	184811	151316355	97934266	92	49981											
RORC	6097	broad.mit.edu	37	chr1	151785525	151785525	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaagatggagctgatgagctCgctgcagcctgatggagtgg	10	8	16	7	1	0	4	0	3	0	1	1	6	0	6	1	3	4	4	1	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:151785525C>T	uc001ezh.2	-	9	1291	c.1183G>A	c.(1183-1185)GAG>AAG	p.E395K	RORC_uc001ezg.2_Missense_Mutation_p.E374K|RORC_uc010pdo.1_Missense_Mutation_p.E449K|RORC_uc010pdp.1_Missense_Mutation_p.E383K	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	395	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTGATGAGCTCGCTGCAGCCT	0.532													4	25					0	0	0	0	T	151785525	T	T	151785525	3	4	276	1	0	0	0	0	1	0	0	0	13595	893	31	1	385	1	RORC	1	151785525	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	469170	151785525	97465096	93	49982											
TCHHL1	126637	broad.mit.edu	37	chr1	152058789	152058789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgctgttccttcaagttcagGgtgagtctgatctcctcctt	5	16	9	11	0	4	2	2	2	2	0	7	2	6	2	3	1	1	3	3	1	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:152058789G>A	uc001ezo.1	-	3	1434	c.1369C>T	c.(1369-1371)CCT>TCT	p.P457S		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	457							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TCAAGTTCAGGGTGAGTCTGA	0.448													93	156					0	0	0	0	A	152058789	A	A	152058789	3	1	276	1	0	0	0	0	1	0	0	0	15767	1232	43	4	1349	4	TCHHL1	1	152058789	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	273264	152058789	97191832	94	49983											
TCHHL1	126637	broad.mit.edu	37	chr1	152059445	152059445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacactttgctctctggctGgttcatctccttcctgggag	6	14	9	12	0	3	0	1	0	2	0	6	1	4	1	2	3	2	3	2	3	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:152059445G>A	uc001ezo.1	-	3	778	c.713C>T	c.(712-714)CCA>CTA	p.P238L		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	238							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CTCTCTGGCTGGTTCATCTCC	0.453													30	123					0	0	0	0	A	152059445	A	A	152059445	3	1	276	1	0	0	0	0	1	0	0	0	15767	1348	47	4	2005	4	TCHHL1	1	152059445	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	656	152059445	97191176	95	49984											
HRNR	388697	broad.mit.edu	37	chr1	152187529	152187529	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtggctggaggagtgcccCgaaccggacccatgtcggcc	6	5	15	15	4	0	0	0	0	0	0	1	4	0	3	6	5	2	1	6	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:152187529C>T	uc001ezt.1	-	3	6652	c.6576G>A	c.(6574-6576)TCG>TCA	p.S2192S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2192	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGGAGTGCCCCGAACCGGACC	0.637													24	419					0	0	0	0	T	152187529	T	T	152187529	2	4	276	1	0	0	0	0	0	0	0	1	7398	639	23	1		1	HRNR	1	152187529	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	128084	152187529	97063092	96	49985											
HRNR	388697	broad.mit.edu	37	chr1	152187634	152187634	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gacccatgctgaccatagcgGgaagacgaacctgagctaga	13	5	12	11	2	0	4	0	2	0	2	0	7	0	5	3	1	4	2	3	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:152187634G>A	uc001ezt.1	-	3	6547	c.6471C>T	c.(6469-6471)TCC>TCT	p.S2157S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2157	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCATAGCGGGAAGACGAAC	0.617													15	885					0	0	0	0	A	152187634	A	A	152187634	2	1	276	1	0	0	0	0	0	0	0	1	7398	1219	43	4		4	HRNR	1	152187634	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	105	152187634	97062987	97	49986											
HRNR	388697	broad.mit.edu	37	chr1	152188177	152188177	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccagactcatatgggccacgGctggaagaccaccctgagcc	10	5	11	15	1	1	3	1	1	0	2	1	4	1	4	5	3	1	1	5	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:152188177G>A	uc001ezt.1	-	3	6004	c.5928C>T	c.(5926-5928)AGC>AGT	p.S1976S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1976	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGGCCACGGCTGGAAGACC	0.602													16	660					0	0	0	0	A	152188177	A	A	152188177	2	1	276	1	0	0	0	0	0	0	0	1	7398	1194	42	4		4	HRNR	1	152188177	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	543	152188177	97062444	98	49987											
HRNR	388697	broad.mit.edu	37	chr1	152191169	152191169	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgaccatagctggaagacGaacctgagctagatccatgt	12	8	11	10	1	0	4	0	2	0	2	1	6	1	5	3	1	3	3	3	1	4	2	rs144088764		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:152191169G>A	uc001ezt.1	-	3	3012	c.2936C>T	c.(2935-2937)TCG>TTG	p.S979L		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	979	11.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGGAAGACGAACCTGAGCT	0.577													62	252					0	0	0	0	A	152191169	A	A	152191169	3	1	276	1	0	0	0	0	1	0	0	0	7398	1059	37	1	5620	1	HRNR	1	152191169	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2992	152191169	97059452	99	49988											
FLG	2312	broad.mit.edu	37	chr1	152278924	152278924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtgtggctgtgatgggacCctgagtgtccagagctatct	6	12	15	8	0	1	3	0	2	1	1	2	4	2	4	2	3	1	2	2	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:152278924C>T	uc001ezu.1	-	3	8474	c.8438G>A	c.(8437-8439)GGG>GAG	p.G2813E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2813	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGATGGGACCCTGAGTGTCC	0.572									Ichthyosis				50	440					0	0	0	0	T	152278924	T	T	152278924	3	4	276	1	0	0	0	0	1	0	0	0	5954	623	22	4	3751	4	FLG	1	152278924	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	87755	152278924	96971697	100	49989											
FLG2	388698	broad.mit.edu	37	chr1	152326846	152326846	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcatgctgtgcaaagccaGaggatttacctgtgcctgac	10	10	10	11	0	1	2	1	1	0	1	1	3	1	3	3	1	5	2	3	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:152326846G>A	uc001ezw.3	-	3	3489	c.3416C>T	c.(3415-3417)TCT>TTT	p.S1139F	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1139	Ser-rich.|Filaggrin 4.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCAAAGCCAGAGGATTTACC	0.537													47	221					0	0	0	0	A	152326846	A	A	152326846	3	1	276	1	0	0	0	0	1	0	0	0	5955	942	33	2	3763	2	FLG2	1	152326846	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	47922	152326846	96923775	101	49990											
LELP1	149018	broad.mit.edu	37	chr1	153177418	153177418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agccctgcaccaagccctgtCctcctaaatgcccttcatcc	8	9	5	19	0	1	0	1	0	0	0	4	0	4	0	7	0	4	1	7	0	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:153177418C>T	uc001fbl.2	+	2	345	c.235C>T	c.(235-237)CCT>TCT	p.P79S		NM_001010857	NP_001010857	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	79	Cys/Pro-rich.									ovary(1)	1	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAAGCCCTGTCCTCCTAAATG	0.632													4	40					0	0	0	0	T	153177418	T	T	153177418	3	4	276	1	0	0	0	0	1	0	0	0	8758	855	30	2	237	2	LELP1	1	153177418	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	850572	153177418	96073203	102	49991											
S100A1	6271	broad.mit.edu	37	chr1	153604235	153604235	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctagacgagaatggagacgGggaggtggacttccaggagt	11	6	18	6	2	0	3	0	0	0	3	1	8	1	6	1	6	0	1	1	6	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:153604235G>A	uc001fck.1	+	3	316	c.203G>A	c.(202-204)GGG>GAG	p.G68E	C1orf77_uc001fcm.1_5'Flank|C1orf77_uc001fcn.1_5'Flank|S100A13_uc001fcj.2_Intron|S100A1_uc001fcl.1_RNA|C1orf77_uc009woi.1_5'Flank|C1orf77_uc009woj.1_5'Flank	NM_006271	NP_006262	P23297	S10A1_HUMAN	S100 calcium binding protein A1	68	2; high affinity.|EF-hand 2.				intracellular signal transduction|regulation of heart contraction	nucleus|protein complex|sarcoplasmic reticulum	ATPase binding|calcium ion binding|protein homodimerization activity|S100 alpha binding|S100 beta binding				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)		Olopatadine(DB00768)	AATGGAGACGGGGAGGTGGAC	0.542													49	232					0	0	0	0	A	153604235	A	A	153604235	3	1	276	1	0	0	0	0	1	0	0	0	13836	1232	43	4	209	4	S100A1	1	153604235	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	426817	153604235	95646386	103	49992											
IL6R	3570	broad.mit.edu	37	chr1	154401817	154401817	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccagcagatgggctggcatGggaaggaggctgctgctgag	8	6	18	9	0	0	2	0	1	0	1	0	4	0	4	1	5	3	6	1	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:154401817G>A	uc001fez.1	+	2	668	c.231G>A	c.(229-231)ATG>ATA	p.M77I	IL6R_uc001ffa.1_Missense_Mutation_p.M77I	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	77	Extracellular (Potential).|Ig-like C2-type.				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGGCTGGCATGGGAAGGAGGC	0.647													12	31					0	0	0	0	A	154401817	A	A	154401817	3	1	276	1	0	0	0	0	1	0	0	0	7741	1348	47	4	237	4	IL6R	1	154401817	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	797582	154401817	94848804	104	49993											
FLAD1	80308	broad.mit.edu	37	chr1	154962042	154962042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcctgcttggcagggtcttCtttggggaaaaaggtggcag	7	11	16	7	0	2	0	0	0	2	0	2	1	2	1	1	6	2	3	1	6	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:154962042C>T	uc001fgf.1	+	3	1478	c.1124C>T	c.(1123-1125)TCT>TTT	p.S375F	FLAD1_uc001fgd.1_Missense_Mutation_p.S375F|FLAD1_uc001fge.1_Missense_Mutation_p.S278F|FLAD1_uc001fgg.1_Missense_Mutation_p.S278F|FLAD1_uc001fgh.1_Intron	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	375					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCAGGGTCTTCTTTGGGGAAA	0.463													15	80					0	0	0	0	T	154962042	T	T	154962042	3	4	276	1	0	0	0	0	1	0	0	0	5952	913	32	2	1274	2	FLAD1	1	154962042	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	560225	154962042	94288579	105	49994											
CLK2	1196	broad.mit.edu	37	chr1	155236562	155236563	+	Nonsense_Mutation	DNP	GG	AA	AA																															gaaggccatgtggcgcacttGgtggatggggtagggcaggt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:155236562_155236563GG>AA	uc001fjy.2	-	7	1085_1086	c.795_796CC>TT	c.(793-798)CACCAA>CATTAA	p.Q266*	RAG1AP1_uc010pey.1_Intron|CLK2_uc001fjw.2_Nonsense_Mutation_p.Q265*|CLK2_uc001fjx.2_Nonsense_Mutation_p.Q38*|CLK2_uc009wqm.2_Nonsense_Mutation_p.Q266*	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	266	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGCGCACTTGGTGGATGGGGT	0.559								Other_conserved_DNA_damage_response_genes					16	22					0	0	0	0	AA	155236563	AA	AA	155236562	4	1	276	1	0	0	0	0	0	1	0	0	3552	1357	47	4	731	4	CLK2	1	155236562	Nonsense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	274520	155236562	94014059	106	49995											
HCN3	57657	broad.mit.edu	37	chr1	155254458	155254458	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcaccatgctcagcatgatCgtaggtgccacatgctacgc	9	9	9	14	2	2	1	2	1	0	0	3	1	2	1	2	1	5	4	2	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:155254458C>T	uc001fjz.1	+	4	1007	c.999C>T	c.(997-999)ATC>ATT	p.I333I	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_Intron	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	333	Helical; Name=Segment S6; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCAGCATGATCGTAGGTGCCA	0.597													8	27					0	0	0	0	T	155254458	T	T	155254458	2	4	276	1	0	0	0	0	0	0	0	1	7037	874	31	1		1	HCN3	1	155254458	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	17896	155254458	93996163	107	49996											
GON4L	54856	broad.mit.edu	37	chr1	155727075	155727076	+	Missense_Mutation	DNP	GG	AA	AA																															agaaaactcatcctgcaggtGgtcgtggcccttgaggagct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:155727075_155727076GG>AA	uc001flz.2	-	26	5389_5390	c.5292_5293CC>TT	c.(5290-5295)GACCAC>GATTAC	p.H1765Y	GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Missense_Mutation_p.H1765Y|GON4L_uc009wrh.1_Missense_Mutation_p.H1765Y|GON4L_uc001fma.1_Missense_Mutation_p.H1765Y|GON4L_uc001fmb.3_Missense_Mutation_p.H961Y	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	1765	PAH 2.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TCCTGCAGGTGGTCGTGGCCCT	0.53													14	81					0	0	0	0	AA	155727076	AA	AA	155727075	3	1	276	1	0	0	0	0	1	0	0	0	6609	1348	47	4	1457	4	GON4L	1	155727075	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	472617	155727075	93523546	108	49997											
SEMA4A	64218	broad.mit.edu	37	chr1	156145017	156145017	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagtcccgaacctgttgcctCctgtctgcccccaacctgtg	5	10	9	17	1	1	0	0	0	1	0	3	2	3	0	7	0	4	1	7	0	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:156145017C>T	uc001fnl.2	+	13	1679	c.1575C>T	c.(1573-1575)CTC>CTT	p.L525L	SEMA4A_uc009wrq.2_Silent_p.L525L|SEMA4A_uc001fnm.2_Silent_p.L525L|SEMA4A_uc001fnn.2_Silent_p.L393L|SEMA4A_uc001fno.2_Silent_p.L525L	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	525	Extracellular (Potential).|PSI.				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCTGTTGCCTCCTGTCTGCCC	0.617													36	133					0	0	0	0	T	156145017	T	T	156145017	2	4	276	1	0	0	0	0	0	0	0	1	14096	842	30	2		2	SEMA4A	1	156145017	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	417942	156145017	93105604	109	49998											
SMG5	23381	broad.mit.edu	37	chr1	156236039	156236039	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccaactttgggtgggtggCggcgacggcggagacaggag	8	5	19	9	4	0	1	0	0	0	1	0	4	0	2	1	7	1	0	1	7	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:156236039C>T	uc001foc.3	-	12	1537	c.1388G>A	c.(1387-1389)CGC>CAC	p.R463H	SMG5_uc009wrv.2_5'UTR	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	463	Poly-Arg.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					GGGTGGGTGGCGGCGACGGCG	0.602													14	114					0	0	0	0	T	156236039	T	T	156236039	3	4	276	1	0	0	0	0	1	0	0	0	14860	768	27	1	1706	1	SMG5	1	156236039	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	91022	156236039	93014582	110	49999											
SMG5	23381	broad.mit.edu	37	chr1	156246880	156246880	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaggttccactgacctatGagggggtcagtgacatgggt	8	11	14	8	0	2	3	2	3	0	0	3	3	3	3	2	4	0	1	2	4	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:156246880G>A	uc001foc.3	-	4	599	c.450C>T	c.(448-450)CTC>CTT	p.L150L		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	150					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					ACTGACCTATGAGGGGGTCAG	0.542													13	40					0	0	0	0	A	156246880	A	A	156246880	2	1	276	1	0	0	0	0	0	0	0	1	14860	1277	45	2		2	SMG5	1	156246880	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	10841	156246880	93003741	111	50000											
RHBG	57127	broad.mit.edu	37	chr1	156348150	156348150	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggagaagagcaagcaccgCcagggctccgtctaccattc	10	6	11	14	2	1	2	0	0	1	2	3	3	2	2	4	2	3	3	4	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:156348150C>T	uc010pho.1	+	4	671	c.633C>T	c.(631-633)CGC>CGT	p.R211R	RHBG_uc010phm.1_Intron|RHBG_uc010phn.1_RNA|RHBG_uc001fos.2_Silent_p.R142R|RHBG_uc009wrz.2_Silent_p.R179R|RHBG_uc001for.2_Silent_p.R181R	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	211	Cytoplasmic (Potential).				transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					GCAAGCACCGCCAGGGCTCCG	0.622													15	128					0	0	0	0	T	156348150	T	T	156348150	2	4	276	1	0	0	0	0	0	0	0	1	13389	726	26	4		4	RHBG	1	156348150	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	101270	156348150	92902471	112	50001											
IQGAP3	128239	broad.mit.edu	37	chr1	156536225	156536225	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgtagatcttcttcaagggaAccacggagggtgcaaaacag	13	7	12	9	2	3	1	1	0	2	1	3	3	3	3	1	3	3	2	1	3	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:156536225A>G	uc001fpf.2	-	3	314	c.239T>C	c.(238-240)GTT>GCT	p.V80A	IQGAP3_uc009wsb.1_Missense_Mutation_p.V37A	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	80	CH.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTTCAAGGGAACCACGGAGGG	0.577													3	25					0	0	0	0	G	156536225	G	G	156536225	3	3	276	1	0	0	0	0	1	0	0	0	7855	43	2	5	4800	5	IQGAP3	1	156536225	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	188075	156536225	92714396	113	50002											
BCAN	63827	broad.mit.edu	37	chr1	156622557	156622558	+	Missense_Mutation	DNP	GG	AA	AA																															cgggcccctgagggtaccagGgagctggaggccccctctga																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:156622557_156622558GG>AA	uc001fpp.2	+	8	2151_2152	c.1815_1816GG>AA	c.(1813-1818)AGGGAG>AGAAAG	p.E606K	BCAN_uc001fpo.2_Missense_Mutation_p.E606K	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	606					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGGTACCAGGGAGCTGGAGGC	0.653													3	27					0	0	0	0	AA	156622558	AA	AA	156622557	3	1	276	1	0	0	0	0	1	0	0	0	1347	1223	43	4	1841	4	BCAN	1	156622557	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	86332	156622557	92628064	114	50003											
PEAR1	375033	broad.mit.edu	37	chr1	156880483	156880483	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactccttctgccacccctcGaacgggacctgctactgcct	6	9	7	19	2	1	0	0	0	1	0	3	2	2	1	6	1	5	1	6	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:156880483G>A	uc001fqj.1	+	15	2015	c.1899G>A	c.(1897-1899)TCG>TCA	p.S633S	PEAR1_uc001fqk.1_Silent_p.S258S	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	633	EGF-like 8.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCACCCCTCGAACGGGACCT	0.617													4	32					0	0	0	0	A	156880483	A	A	156880483	2	1	276	1	0	0	0	0	0	0	0	1	11766	1045	37	1		1	PEAR1	1	156880483	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	257926	156880483	92370138	115	50004											
ARHGEF11	9826	broad.mit.edu	37	chr1	156909465	156909465	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgggggtaggtgttccagaGaacagagacccatgtcttcc	9	10	13	9	0	1	2	0	0	1	2	3	4	3	2	3	3	1	2	3	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:156909465G>A	uc001fqo.2	-	36	4891	c.3851C>T	c.(3850-3852)TCT>TTT	p.S1284F	ARHGEF11_uc010phu.1_Missense_Mutation_p.S700F|ARHGEF11_uc001fqn.2_Missense_Mutation_p.S1324F	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1284					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTGTTCCAGAGAACAGAGACC	0.592													23	37					0	0	0	0	A	156909465	A	A	156909465	3	1	276	1	0	0	0	0	1	0	0	0	896	942	33	2	737	2	ARHGEF11	1	156909465	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	28982	156909465	92341156	116	50005											
FCRL4	83417	broad.mit.edu	37	chr1	157559185	157559185	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattgcaagtcagagtcactCtctctcctttgaagaatgtg	10	13	8	10	0	4	3	2	1	2	2	6	3	4	3	1	0	1	1	1	0	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:157559185C>T	uc001fqw.2	-	3	252	c.116G>A	c.(115-117)AGA>AAA	p.R39K	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	39	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				CAGAGTCACTCTCTCTCCTTT	0.483													8	35					0	0	0	0	T	157559185	T	T	157559185	3	4	276	1	0	0	0	0	1	0	0	0	5829	913	32	2	1471	2	FCRL4	1	157559185	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	649720	157559185	91691436	117	50006											
OR10T2	128360	broad.mit.edu	37	chr1	158368957	158368957	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccaaggaaaaagaacagctgGgtggcacaggccatgaagga	16	3	14	8	0	0	2	0	1	0	1	0	4	0	4	2	5	2	2	2	5	5	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:158368957G>A	uc010pih.1	-	1	300	c.300C>T	c.(298-300)ACC>ACT	p.T100T		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	100	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					AGAACAGCTGGGTGGCACAGG	0.493													8	47					0	0	0	0	A	158368957	A	A	158368957	2	1	276	1	0	0	0	0	0	0	0	1	10973	1219	43	4		4	OR10T2	1	158368957	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	809772	158368957	90881664	118	50007											
OR10K1	391109	broad.mit.edu	37	chr1	158436049	158436049	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaaaatcccttcctccgttgGaagatacaagaccttctcca	13	10	5	13	1	1	2	0	0	1	2	5	3	4	3	5	1	1	1	5	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:158436049G>A	uc010pij.1	+	1	698	c.698G>A	c.(697-699)GGA>GAA	p.G233E		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCCTCCGTTGGAAGATACAAG	0.448													18	87					0	0	0	0	A	158436049	A	A	158436049	3	1	276	1	0	0	0	0	1	0	0	0	10967	1174	41	2	700	2	OR10K1	1	158436049	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	67092	158436049	90814572	119	50008											
OR6K6	128371	broad.mit.edu	37	chr1	158724701	158724701	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acacagttgacggccagtggGaatcagacaatggtgactga	13	7	13	8	1	1	4	1	3	0	1	1	5	1	5	1	3	0	1	1	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:158724701G>A	uc001fsw.1	+	1	96	c.96G>A	c.(94-96)GGG>GGA	p.G32G		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	32	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					CGGCCAGTGGGAATCAGACAA	0.433													26	91					0	0	0	0	A	158724701	A	A	158724701	2	1	276	1	0	0	0	0	0	0	0	1	11258	1161	41	2		2	OR6K6	1	158724701	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	288652	158724701	90525920	120	50009											
DARC	2532	broad.mit.edu	37	chr1	159176033	159176033	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggatttcctggtgaggtcCaagctgttgctgttgtcaac	6	14	12	9	0	1	1	1	1	0	0	3	2	3	2	2	3	3	4	2	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:159176033C>T	uc001fto.2	+	2	1044	c.804C>T	c.(802-804)TCC>TCT	p.S268S	DARC_uc001ftp.3_Silent_p.S270S	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	268	Extracellular (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					TGGTGAGGTCCAAGCTGTTGC	0.572													26	110					0	0	0	0	T	159176033	T	T	159176033	2	4	276	1	0	0	0	0	0	0	0	1	4257	581	21	4		4	DARC	1	159176033	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	451332	159176033	90074588	121	50010											
NHLH1	4807	broad.mit.edu	37	chr1	160340725	160340726	+	Missense_Mutation	DNP	CC	TT	TT																															agccgcgaggagcgccggcgCcggcgccgcgccacagccaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:160340725_160340726CC>TT	uc001fwa.2	+	2	646_647	c.204_205CC>TT	c.(202-207)CGCCGG>CGTTGG	p.R69W		NM_005598	NP_005589	Q02575	HEN1_HUMAN	nescient helix loop helix 1	69	Poly-Arg.				cell differentiation|central nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_cancers(52;7.11e-19)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			Agcgccggcgccggcgccgcgc	0.634													7	10					0	0	0	0	TT	160340726	TT	TT	160340725	3	4	276	1	0	0	0	0	1	0	0	0	10457	726	26	4	206	4	NHLH1	1	160340725	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1164692	160340725	88909896	122	50011											
ITLN1	55600	broad.mit.edu	37	chr1	160849204	160849204	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caaatcccgcagtgaattccCctgaaaacaagaggcagaaa	17	5	8	11	1	0	4	0	2	0	2	2	4	2	4	3	1	1	2	3	1	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:160849204C>T	uc001fxc.2	-	7	802	c.686G>A	c.(685-687)CGG>CAG	p.R229Q		NM_017625	NP_060095	Q8WWA0	ITLN1_HUMAN	intelectin precursor	229	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)	7	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AGTGAATTCCCCTGAAAACAA	0.493													9	40					0	0	0	0	T	160849204	T	T	160849204	3	4	276	1	0	0	0	0	1	0	0	0	7949	637	22	4	263	4	ITLN1	1	160849204	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	508479	160849204	88401417	123	50012											
ARHGAP30	257106	broad.mit.edu	37	chr1	161018122	161018122	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgcccctcaggctccatctCctctggctgaggtggctgtg	3	11	12	15	0	3	1	1	1	2	0	5	1	4	1	4	4	1	3	4	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:161018122C>T	uc001fxl.2	-	12	3035	c.2689G>A	c.(2689-2691)GAG>AAG	p.E897K	USF1_uc001fxi.2_5'Flank|USF1_uc001fxj.2_5'Flank|ARHGAP30_uc001fxk.2_Missense_Mutation_p.E686K|ARHGAP30_uc001fxm.2_Missense_Mutation_p.E743K|ARHGAP30_uc009wtx.2_Missense_Mutation_p.E570K	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	897	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GGCTCCATCTCCTCTGGCTGA	0.597													7	30					0	0	0	0	T	161018122	T	T	161018122	3	4	276	1	0	0	0	0	1	0	0	0	879	864	30	2	620	2	ARHGAP30	1	161018122	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	168918	161018122	88232499	124	50013											
ADAMTS4	9507	broad.mit.edu	37	chr1	161168017	161168017	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgccaccgactccggatctCcattgatggtgccagtcagg	8	9	11	13	2	2	1	1	1	1	0	4	3	3	2	5	3	2	0	5	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:161168017C>T	uc001fyt.3	-	1	829	c.401G>A	c.(400-402)GGA>GAA	p.G134E	ADAMTS4_uc001fyu.2_Missense_Mutation_p.G134E|NDUFS2_uc001fyv.2_5'Flank	NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	134					proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CTCCGGATCTCCATTGATGGT	0.637													14	49					0	0	0	0	T	161168017	T	T	161168017	3	4	276	1	0	0	0	0	1	0	0	0	268	855	30	2	2148	2	ADAMTS4	1	161168017	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	149895	161168017	88082604	125	50014											
SH2D1B	117157	broad.mit.edu	37	chr1	162368801	162368801	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttaaaaggtgaaccaccatcCcctgatttggtttttcaaat	12	14	6	9	0	1	2	1	2	0	0	2	2	2	2	4	2	1	1	4	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:162368801C>T	uc001gbz.1	-	3	397	c.275G>A	c.(274-276)GGG>GAG	p.G92E	SH2D1B_uc001gca.1_Intron	NM_053282	NP_444512	O14796	SH21B_HUMAN	SH2 domain containing 1B	92	SH2.									pancreas(1)	1	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			AACCACCATCCCCTGATTTGG	0.398													9	62					0	0	0	0	T	162368801	T	T	162368801	3	4	276	1	0	0	0	0	1	0	0	0	14296	623	22	4	131	4	SH2D1B	1	162368801	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1200784	162368801	86881820	126	50015											
FAM78B	149297	broad.mit.edu	37	chr1	166039968	166039968	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cactgatggcttttactctcCcttccctcaagtcaggcagt	7	13	7	14	0	3	1	2	1	1	0	5	1	4	1	2	2	1	2	2	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:166039968C>T	uc001gdr.2	-	3	886	c.296G>A	c.(295-297)GGG>GAG	p.G99E	FAM78B_uc010plc.1_RNA|FAM78B_uc001gdq.2_5'Flank	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	99										central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					TTTTACTCTCCCTTCCCTCAA	0.507													10	44					0	0	0	0	T	166039968	T	T	166039968	3	4	276	1	0	0	0	0	1	0	0	0	5659	623	22	4	493	4	FAM78B	1	166039968	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3671167	166039968	83210653	127	50016											
C1orf114	57821	broad.mit.edu	37	chr1	169390941	169390941	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttctgtactatttgcattaTtaatgggaggcaaaaacccc	12	14	7	8	0	1	0	0	0	1	0	1	1	1	1	2	2	3	3	2	2	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:169390941T>A	uc001gga.1	-	3	896	c.728A>T	c.(727-729)AAT>ATT	p.N243I	C1orf114_uc001gfz.1_Missense_Mutation_p.N243I|C1orf114_uc009wvq.1_Missense_Mutation_p.N243I|C1orf114_uc001ggb.2_Missense_Mutation_p.N243I|C1orf114_uc001ggc.1_Missense_Mutation_p.N243I	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	243											0	all_hematologic(923;0.208)					ATTTGCATTATTAATGGGAGG	0.398													25	100					0	0	0	0	A	169390941	A	A	169390941	3	1	276	1	0	0	0	0	1	0	0	0	1996	1493	52	5	814	5	C1orf114	1	169390941	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	3350973	169390941	79859680	128	50017											
F5	2153	broad.mit.edu	37	chr1	169511036	169511036	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggaattctgattatggtcagGaagtgaggctatccagccaa	12	10	12	7	0	2	2	1	2	1	0	3	4	3	4	2	4	1	1	2	4	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:169511036G>A	uc001ggg.1	-	13	3437	c.3292C>T	c.(3292-3294)CCT>TCT	p.P1098S		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1098	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTATGGTCAGGAAGTGAGGCT	0.458													28	106					0	0	0	0	A	169511036	A	A	169511036	3	1	276	1	0	0	0	0	1	0	0	0	5373	1174	41	2	3434	2	F5	1	169511036	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	120095	169511036	79739585	129	50018											
SELP	6403	broad.mit.edu	37	chr1	169578891	169578891	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atggagagcaatccatgcttCcgtggacaggactctccagc	10	8	11	12	1	1	1	0	0	1	1	4	4	3	3	3	3	3	2	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:169578891C>T	uc001ggi.3	-	8	1249	c.1184G>A	c.(1183-1185)GGA>GAA	p.G395E	SELP_uc001ggh.2_Missense_Mutation_p.G230E|SELP_uc009wvr.2_Missense_Mutation_p.G395E	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	395	Sushi 4.|Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	ATCCATGCTTCCGTGGACAGG	0.488													4	34					0	0	0	0	T	169578891	T	T	169578891	3	4	276	1	0	0	0	0	1	0	0	0	14084	855	30	2	1344	2	SELP	1	169578891	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	67855	169578891	79671730	130	50019											
FMO3	2328	broad.mit.edu	37	chr1	171083464	171083464	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggggctgccattcccacagTtgacctccagtcccgctggg	5	9	12	15	1	0	1	0	1	0	0	3	1	3	1	5	3	1	3	5	3	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:171083464T>C	uc001ghi.2	+	7	1256	c.1145T>C	c.(1144-1146)GTT>GCT	p.V382A	FMO3_uc001ghh.2_Missense_Mutation_p.V382A|FMO3_uc010pmb.1_Missense_Mutation_p.V362A|FMO3_uc010pmc.1_Missense_Mutation_p.V319A	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	382					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATTCCCACAGTTGACCTCCAG	0.453													20	23					0	0	0	0	C	171083464	C	C	171083464	3	2	276	1	0	0	0	0	1	0	0	0	5988	1725	60	5	1167	5	FMO3	1	171083464	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1504573	171083464	78167157	131	50020											
FMO2	2327	broad.mit.edu	37	chr1	171173050	171173050	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggtcatgagccgtatctCtgaagatggctatccttggg	7	12	13	9	1	2	3	1	2	1	1	4	3	3	3	2	3	1	2	2	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:171173050C>T	uc001ghk.1	+	6	791	c.674C>T	c.(673-675)TCT>TTT	p.S225F	FMO2_uc010pmd.1_Missense_Mutation_p.S5F	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	225					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGCCGTATCTCTGAAGATGGC	0.473													8	30					0	0	0	0	T	171173050	T	T	171173050	3	4	276	1	0	0	0	0	1	0	0	0	5987	913	32	2	692	2	FMO2	1	171173050	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	89586	171173050	78077571	132	50021											
TNR	7143	broad.mit.edu	37	chr1	175306677	175306677	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tacttacaatccagccgcccCcgtcggtggtcatatcacag	9	9	8	15	3	2	0	2	0	0	0	4	0	3	0	4	2	3	0	4	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:175306677C>T	uc001gkp.1	-	17	3602	c.3521G>A	c.(3520-3522)GGG>GAG	p.G1174E	TNR_uc009wwu.1_Missense_Mutation_p.G1174E	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1174	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CCAGCCGCCCCCGTCGGTGGT	0.502													19	34					0	0	0	0	T	175306677	T	T	175306677	3	4	276	1	0	0	0	0	1	0	0	0	16404	623	22	4	575	4	TNR	1	175306677	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4133627	175306677	73943944	133	50022											
ASTN1	460	broad.mit.edu	37	chr1	176863845	176863845	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtcccttgctgtggcactcCatgcggactccagccgccat	5	9	10	17	3	0	0	0	0	0	0	3	1	3	1	5	2	3	2	5	2	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:176863845C>T	uc001glc.2	-	17	3005	c.2793G>A	c.(2791-2793)ATG>ATA	p.M931I	ASTN1_uc001glb.1_Missense_Mutation_p.M931I|ASTN1_uc001gld.1_Missense_Mutation_p.M931I	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	939					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TGTGGCACTCCATGCGGACTC	0.612													13	76					0	0	0	0	T	176863845	T	T	176863845	3	4	276	1	0	0	0	0	1	0	0	0	1066	594	21	4	1123	4	ASTN1	1	176863845	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1557168	176863845	72386776	134	50023											
ASTN1	460	broad.mit.edu	37	chr1	176927501	176927501	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacctccacagcatcctcCatcacagtcatgtccgtctt	8	11	5	17	1	3	1	2	1	1	0	7	1	7	1	5	0	1	1	5	0	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:176927501C>T	uc001glc.2	-	10	1928	c.1716G>A	c.(1714-1716)ATG>ATA	p.M572I	ASTN1_uc001glb.1_Missense_Mutation_p.M572I|ASTN1_uc001gld.1_Missense_Mutation_p.M572I|ASTN1_uc009wwx.1_Missense_Mutation_p.M572I	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	580					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CAGCATCCTCCATCACAGTCA	0.537													32	49					0	0	0	0	T	176927501	T	T	176927501	3	4	276	1	0	0	0	0	1	0	0	0	1066	594	21	4	2228	4	ASTN1	1	176927501	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	63656	176927501	72323120	135	50024											
SEC16B	89866	broad.mit.edu	37	chr1	177909754	177909754	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atcccactcacctccagctgCctccgaagttgcgctagcca	8	8	7	18	2	1	0	1	0	0	0	4	1	4	0	6	0	4	3	6	0	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:177909754C>T	uc001gli.1	-	17	2208	c.2118G>A	c.(2116-2118)AGG>AGA	p.R706R	SEC16B_uc001glk.1_Silent_p.R383R|SEC16B_uc009wwy.1_Silent_p.R261R|SEC16B_uc001glh.1_Silent_p.R365R|SEC16B_uc009wwz.1_Silent_p.R365R|SEC16B_uc001glj.1_Silent_p.R707R	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	706					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						CCTCCAGCTGCCTCCGAAGTT	0.557													7	24					0	0	0	0	T	177909754	T	T	177909754	2	4	276	1	0	0	0	0	0	0	0	1	14052	738	26	4		4	SEC16B	1	177909754	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	982253	177909754	71340867	136	50025											
CACNA1E	777	broad.mit.edu	37	chr1	181741312	181741312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaacgagaacgaacgctgcgGcaccgatctggcctacgtgt	10	6	13	12	6	1	1	0	0	1	1	1	5	1	1	2	2	5	2	2	2	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:181741312G>A	uc001gow.2	+	37	5249	c.5084G>A	c.(5083-5085)GGC>GAC	p.G1695D	CACNA1E_uc009wxs.2_Missense_Mutation_p.G1583D|CACNA1E_uc001gox.1_Missense_Mutation_p.G921D|CACNA1E_uc009wxt.2_Missense_Mutation_p.G921D	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1695	Extracellular (Potential).|IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GAACGCTGCGGCACCGATCTG	0.557													61	100					0	0	0	0	A	181741312	A	A	181741312	3	1	276	1	0	0	0	0	1	0	0	0	2554	1203	42	4	5230	4	CACNA1E	1	181741312	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3831558	181741312	67509309	137	50026											
DHX9	1660	broad.mit.edu	37	chr1	182856371	182856371	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatggtggcagcgccaactcCtttcgggcaggatatggtgc	7	10	14	10	2	0	0	0	0	0	0	2	1	1	1	2	5	3	2	2	5	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:182856371C>A	uc001gpr.2	+	28	3778	c.3615C>A	c.(3613-3615)TCC>TCA	p.S1205S	DHX9_uc001gps.2_Silent_p.S991S|DHX9_uc001gpt.2_Silent_p.S484S|DHX9_uc009wyd.2_Silent_p.S170S	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	1205	NTD.			NSFRAGYG -> TPSGRIC (in Ref. 1; AAB48855).	CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						GCGCCAACTCCTTTCGGGCAG	0.557													22	97					3.8784e-16	4.008e-16	1	0	A	182856371	A	A	182856371	2	1	276	1	0	0	0	0	0	0	0	1	4538	668	24	4		4	DHX9	1	182856371	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1115059	182856371	66394250	138	50027											
HMCN1	83872	broad.mit.edu	37	chr1	186092317	186092317	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catggcagccaatgtagcagGatcaagcagcacaagcacca	15	4	10	12	0	1	0	1	0	0	0	1	1	1	1	2	2	5	6	2	2	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:186092317G>A	uc001grq.1	+	81	12693	c.12464G>A	c.(12463-12465)GGA>GAA	p.G4155E		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4155	Ig-like C2-type 40.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AATGTAGCAGGATCAAGCAGC	0.502													7	26					0	0	0	0	A	186092317	A	A	186092317	3	1	276	1	0	0	0	0	1	0	0	0	7259	1174	41	2	12786	2	HMCN1	1	186092317	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3235946	186092317	63158304	139	50028											
GLRX2	51022	broad.mit.edu	37	chr1	193065760	193065760	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttattagtataaacatcactGaaattctttcctcttacttt	12	19	2	8	0	3	1	1	1	2	0	4	1	4	1	1	0	2	1	1	0	7	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:193065760G>A	uc001gsz.1	-	4	534	c.490C>T	c.(490-492)CAG>TAG	p.Q164*	GLRX2_uc001gta.1_Nonsense_Mutation_p.Q165*	NM_197962	NP_932066	Q9NS18	GLRX2_HUMAN	glutaredoxin 2 isoform 2	164					apoptosis|cell differentiation|cell redox homeostasis|DNA protection|electron transport chain|glutathione metabolic process|protein thiol-disulfide exchange|regulation of signal transduction|regulation of transcription, DNA-dependent|response to hydrogen peroxide|response to organic substance|response to redox state|response to temperature stimulus|transport	mitochondrion|nucleus	2 iron, 2 sulfur cluster binding|arsenate reductase (glutaredoxin) activity|electron carrier activity|glutathione disulfide oxidoreductase activity|metal ion binding|protein disulfide oxidoreductase activity				0					Glutathione(DB00143)	AAACATCACTGAAATTCTTTC	0.323													12	9					0	0	0	0	A	193065760	A	A	193065760	4	1	276	1	0	0	0	0	0	1	0	0	6497	1299	45	2	8	2	GLRX2	1	193065760	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6973443	193065760	56184861	140	50029											
KCNT2	343450	broad.mit.edu	37	chr1	196438186	196438186	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggtattcgtaaaatctgttCccagatgtttcccttccaag	9	14	8	10	1	1	1	0	0	1	1	5	1	4	1	3	1	0	4	3	1	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:196438186C>T	uc001gtd.1	-	6	457	c.397G>A	c.(397-399)GAA>AAA	p.E133K	KCNT2_uc009wyt.1_5'Flank|KCNT2_uc001gte.1_Missense_Mutation_p.E133K|KCNT2_uc001gtf.1_Missense_Mutation_p.E133K|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.E133K|KCNT2_uc009wyv.1_Intron	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	133	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						AAAATCTGTTCCCAGATGTTT	0.338													4	13					0	0	0	0	T	196438186	T	T	196438186	3	4	276	1	0	0	0	0	1	0	0	0	8131	864	30	2	3102	2	KCNT2	1	196438186	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3372426	196438186	52812435	141	50030											
CFHR1	3078	broad.mit.edu	37	chr1	196796106	196796106	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcatgtgtagaacggggctGgtccacccctcccaaatgca	9	9	10	13	1	1	1	1	0	0	1	3	1	3	1	4	3	2	3	4	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:196796106G>A	uc001gtn.2	+	3	515	c.401G>A	c.(400-402)TGG>TAG	p.W134*	CFHR1_uc001gtm.2_Intron	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	134	Sushi 2.				complement activation	extracellular space					0						GAACGGGGCTGGTCCACCCCT	0.388													28	68					0	0	0	0	A	196796106	A	A	196796106	4	1	276	1	0	0	0	0	0	1	0	0	3299	1357	47	4	411	4	CFHR1	1	196796106	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	357920	196796106	52454515	142	50031											
ZBTB41	360023	broad.mit.edu	37	chr1	197160945	197160945	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctgtgaacagttaggttaGactttgttgaatagcgctgg	9	15	12	5	1	1	3	0	2	1	1	1	3	1	3	0	2	2	4	0	2	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:197160945G>C	uc001gtx.1	-	2	1274	c.1205C>G	c.(1204-1206)TCT>TGT	p.S402C	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	402	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						AGTTAGGTTAGACTTTGTTGA	0.378													5	27					0	0	0	0	C	197160945	C	C	197160945	3	2	276	1	0	0	0	0	1	0	0	0	17610	942	33	2	1560	2	ZBTB41	1	197160945	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	364839	197160945	52089676	143	50032											
CRB1	23418	broad.mit.edu	37	chr1	197297819	197297819	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgtgaaactaccattggttCctgtggcaagaactcctgcc	9	11	9	12	0	0	2	0	1	0	1	2	2	2	2	4	2	4	2	4	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:197297819C>T	uc001gtz.2	+	2	473	c.338C>T	c.(337-339)TCC>TTC	p.S113F	CRB1_uc010poz.1_Missense_Mutation_p.S44F|CRB1_uc001gty.1_Missense_Mutation_p.S113F|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.S113F|CRB1_uc010ppb.1_Missense_Mutation_p.S113F	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	113	Extracellular (Potential).|EGF-like 3.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ACCATTGGTTCCTGTGGCAAG	0.498													17	28					0	0	0	0	T	197297819	T	T	197297819	3	4	276	1	0	0	0	0	1	0	0	0	3863	855	30	2	344	2	CRB1	1	197297819	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	136874	197297819	51952802	144	50033											
CRB1	23418	broad.mit.edu	37	chr1	197404489	197404490	+	Missense_Mutation	DNP	CC	GT	GT																															gctcttatcattgctcctgtCccttgggatggtcagggaaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:197404489_197404490CC>GT	uc001gtz.2	+	9	3631_3632	c.3496_3497CC>GT	c.(3496-3498)CCC>GTC	p.P1166V	CRB1_uc010poz.1_Missense_Mutation_p.P1142V|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.P1054V|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.P647V|CRB1_uc001gub.1_Missense_Mutation_p.P815V	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1166	Extracellular (Potential).|EGF-like 15.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TTGCTCCTGTCCCTTGGGATGG	0.475													20	40					0	0	0	0	GT	197404490	GT	GT	197404489	3	3	276	1	0	0	0	0	1	0	0	0	3863	855	30	2	3530	2	CRB1	1	197404489	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	106670	197404489	51846132	145	50034											
PTPRC	5788	broad.mit.edu	37	chr1	198671529	198671529	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgcagatgtcccaggagaGaggagtacagccagcacctt	12	7	12	10	0	0	2	0	0	0	2	1	5	1	4	3	2	4	3	3	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:198671529G>A	uc001gur.1	+	6	627	c.447G>A	c.(445-447)GAG>GAA	p.E149E	PTPRC_uc001gus.1_Intron|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Intron|PTPRC_uc009wzf.1_Intron|PTPRC_uc010ppg.1_Silent_p.E85E|PTPRC_uc001guu.1_Silent_p.E192E|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_Intron	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	149	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TCCCAGGAGAGAGGAGTACAG	0.522													24	114					0	0	0	0	A	198671529	A	A	198671529	2	1	276	1	0	0	0	0	0	0	0	1	12862	933	33	2		2	PTPRC	1	198671529	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1267040	198671529	50579092	146	50035											
IPO9	55705	broad.mit.edu	37	chr1	201821287	201821288	+	Missense_Mutation	DNP	CC	TT	TT																															cttgttgctcctgtcattctCccagagatgtataagatctt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:201821287_201821288CC>TT	uc001gwz.2	+	5	620_621	c.570_571CC>TT	c.(568-573)CTCCCA>CTTTCA	p.P191S		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	191					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						CTGTCATTCTCCCAGAGATGTA	0.421													10	43					0	0	0	0	TT	201821288	TT	TT	201821287	3	4	276	1	0	0	0	0	1	0	0	0	7838	842	30	2	588	2	IPO9	1	201821287	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	3149758	201821287	47429334	147	50036											
LGR6	59352	broad.mit.edu	37	chr1	202245593	202245594	+	Missense_Mutation	DNP	CC	TT	TT																															gccatgaccctggccctcaaCcgcatcagccacatccccga																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:202245593_202245594CC>TT	uc001gxu.2	+	5	588_589	c.588_589CC>TT	c.(586-591)AACCGC>AATTGC	p.R197C	LGR6_uc001gxv.2_Missense_Mutation_p.R145C|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Intron|LGR6_uc009xac.1_RNA	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	197	LRR 5.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TGGCCCTCAACCGCATCAGCCA	0.639													6	23					0	0	0	0	TT	202245594	TT	TT	202245593	3	4	276	1	0	0	0	0	1	0	0	0	8799	506	18	4	753	4	LGR6	1	202245593	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	424306	202245593	47005028	148	50037											
PPFIA4	8497	broad.mit.edu	37	chr1	203024700	203024701	+	Missense_Mutation	DNP	CC	TT	TT																															cacctctctgacggccctgtCcctggccagcgcgtccccac																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:203024700_203024701CC>TT	uc001gyz.2	+	3	1045_1046	c.452_453CC>TT	c.(451-453)TCC>TTT	p.S151F	PPFIA4_uc009xaj.2_Missense_Mutation_p.S782F|PPFIA4_uc010pqf.1_Missense_Mutation_p.S364F|PPFIA4_uc001gza.2_Missense_Mutation_p.S151F|PPFIA4_uc001gzb.1_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	151					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						ACGGCCCTGTCCCTGGCCAGCG	0.644													3	40					0	0	0	0	TT	203024701	TT	TT	203024700	3	4	276	1	0	0	0	0	1	0	0	0	12367	855	30	2	462	2	PPFIA4	1	203024700	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	779107	203024700	46225921	149	50038											
CHI3L1	1116	broad.mit.edu	37	chr1	203149598	203149598	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctccccaactccattacCtcatagtaggcaagggtccc	9	10	6	16	0	2	0	1	0	1	0	5	0	4	0	5	2	2	2	5	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:203149598C>T	uc001gzi.2	-	8	1065	c.894G>A	c.(892-894)GAG>GAA	p.E298E	FMOD_uc010pqi.1_Intron|CHI3L1_uc001gzk.1_Intron|CHI3L1_uc001gzj.2_Intron|CHI3L1_uc001gzl.3_5'Flank	NM_001276	NP_001267	P36222	CH3L1_HUMAN	chitinase 3-like 1 precursor	298					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			pancreas(1)	1						ACTCCATTACCTCATAGTAGG	0.552													10	37					0	0	0	0	T	203149598	T	T	203149598	2	4	276	1	0	0	0	0	0	0	0	1	3355	695	24	4		4	CHI3L1	1	203149598	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	124898	203149598	46101023	150	50039											
REN	5972	broad.mit.edu	37	chr1	204124207	204124207	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aactctgtgtagaactttcgGatgaaggtggcccccagggc	9	9	13	10	1	1	2	0	1	1	1	2	3	1	3	2	4	2	1	2	4	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:204124207G>A	uc001haq.2	-	10	1202	c.1158C>T	c.(1156-1158)ATC>ATT	p.I386I	ETNK2_uc001hao.3_5'Flank|ETNK2_uc001han.3_5'Flank|ETNK2_uc010pqs.1_5'Flank|ETNK2_uc010pqt.1_5'Flank	NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	386					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AGAACTTTCGGATGAAGGTGG	0.607													10	43					0	0	0	0	A	204124207	A	A	204124207	2	1	276	1	0	0	0	0	0	0	0	1	13289	1164	41	2		2	REN	1	204124207	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	974609	204124207	45126414	151	50040											
MDM4	4194	broad.mit.edu	37	chr1	204518442	204518442	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcgaagaaccatttcggctCctgtcgttagacctaaagat	11	11	9	10	3	0	3	0	0	0	3	4	4	1	3	3	1	1	2	3	1	5	3	rs140091735	by1000genomes	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:204518442C>T	uc001hba.2	+	11	1267	c.1105C>T	c.(1105-1107)CCT>TCT	p.P369S	MDM4_uc001hbd.1_RNA|MDM4_uc010pqw.1_RNA|MDM4_uc010pqx.1_Missense_Mutation_p.P242S|MDM4_uc001hay.1_Missense_Mutation_p.P319S|MDM4_uc001hbb.2_Missense_Mutation_p.P242S|MDM4_uc010pqy.1_Intron|MDM4_uc001hbc.2_RNA|MDM4_uc009xbe.1_RNA	NM_002393	NP_002384	O15151	MDM4_HUMAN	mouse double minute 4 homolog	369					apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)			CATTTCGGCTCCTGTCGTTAG	0.408			A		GBM|bladder|retinoblastoma								55	89					0	0	0	0	T	204518442	T	T	204518442	3	4	276	1	0	0	0	0	1	0	0	0	9467	855	30	2	1143	2	MDM4	1	204518442	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	394235	204518442	44732179	152	50041											
CNTN2	6900	broad.mit.edu	37	chr1	205042324	205042324	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggaccacagggcccggaggGgatgggatccctgcagaagt	9	4	17	11	2	0	1	0	0	0	1	1	5	1	5	3	6	1	1	3	6	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:205042324G>A	uc001hbr.2	+	22	3242	c.2973G>A	c.(2971-2973)GGG>GGA	p.G991G	CNTN2_uc001hbs.2_Silent_p.G779G	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	991	Fibronectin type-III 4.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGCCCGGAGGGGATGGGATCC	0.577													14	53					0	0	0	0	A	205042324	A	A	205042324	2	1	276	1	0	0	0	0	0	0	0	1	3656	1219	43	4		4	CNTN2	1	205042324	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	523882	205042324	44208297	153	50042											
KLHDC8A	55220	broad.mit.edu	37	chr1	205306655	205306655	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtgtgggcatggcagggaGgatctcccatttgttcttcc	5	12	15	9	0	2	0	0	0	2	0	4	2	3	2	2	5	0	3	2	5	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:205306655G>A	uc001hcf.1	-	6	1493	c.925C>T	c.(925-927)CTC>TTC	p.L309F	KLHDC8A_uc010prg.1_Missense_Mutation_p.L196F|KLHDC8A_uc001hcg.1_Missense_Mutation_p.L309F	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	309	Kelch 7.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ATGGCAGGGAGGATCTCCCAT	0.572													30	121					0	0	0	0	A	205306655	A	A	205306655	3	1	276	1	0	0	0	0	1	0	0	0	8401	1000	35	4	131	4	KLHDC8A	1	205306655	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	264331	205306655	43943966	154	50043											
SLC26A9	115019	broad.mit.edu	37	chr1	205904874	205904874	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggtatgtccggtccttcttCtcaaactcatcgtcgaagag	8	12	10	11	3	3	1	2	0	2	1	8	2	5	1	2	2	1	1	2	2	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:205904874C>T	uc001hdq.2	-	2	189	c.75G>A	c.(73-75)GAG>GAA	p.E25E	SLC26A9_uc001hdp.2_Silent_p.E25E	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	25						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GGTCCTTCTTCTCAAACTCAT	0.542													28	115					0	0	0	0	T	205904874	T	T	205904874	2	4	276	1	0	0	0	0	0	0	0	1	14588	912	32	2		2	SLC26A9	1	205904874	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	598219	205904874	43345747	155	50044											
CTSE	1510	broad.mit.edu	37	chr1	206317632	206317632	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggagctgggagaggcccaagGatcccttcacaggtgagaag	11	5	16	9	0	1	2	1	1	0	2	2	6	2	4	2	5	1	1	2	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:206317632G>A	uc001hdu.2	+	1	174	c.56G>A	c.(55-57)GGA>GAA	p.G19E	CTSE_uc001hdv.2_Missense_Mutation_p.G19E|CTSE_uc010prs.1_5'UTR	NM_001910	NP_001901	P14091	CATE_HUMAN	cathepsin E isoform a preproprotein	19					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GAGGCCCAAGGATCCCTTCAC	0.582													20	49					0	0	0	0	A	206317632	A	A	206317632	3	1	276	1	0	0	0	0	1	0	0	0	4050	1174	41	2	58	2	CTSE	1	206317632	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	412758	206317632	42932989	156	50045											
DYRK3	8444	broad.mit.edu	37	chr1	206821332	206821332	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggagcatcttaagaaacaGgataaaactggtagtatgaa	17	10	10	4	0	1	2	0	1	1	1	1	4	1	4	0	3	3	3	0	3	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:206821332G>A	uc001hej.2	+	3	957	c.789G>A	c.(787-789)CAG>CAA	p.Q263Q	DYRK3_uc001hek.2_Intron|DYRK3_uc001hei.2_Silent_p.Q243Q	NM_003582	NP_003573	O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	263	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|central_nervous_system(1)	3	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			TTAAGAAACAGGATAAAACTG	0.443													24	110					0	0	0	0	A	206821332	A	A	206821332	2	1	276	1	0	0	0	0	0	0	0	1	4879	991	35	4		4	DYRK3	1	206821332	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	503700	206821332	42429289	157	50046											
IL10	3586	broad.mit.edu	37	chr1	206945859	206945859	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tagaccttcacctctctgtcCcccttttatattgtaagctc	7	16	4	14	0	2	1	1	0	1	1	5	1	3	1	4	0	1	2	4	0	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:206945859C>T	uc001hen.1	-						IL10_uc009xbx.2_RNA	NM_000572	NP_000563	P22301	IL10_HUMAN	interleukin 10 precursor						anti-apoptosis|B cell differentiation|B cell proliferation|cytoplasmic sequestering of NF-kappaB|inflammatory response|leukocyte chemotaxis|negative regulation of B cell proliferation|negative regulation of cytokine secretion involved in immune response|negative regulation of interferon-alpha biosynthetic process|negative regulation of interleukin-6 production|negative regulation of membrane protein ectodomain proteolysis|negative regulation of MHC class II biosynthetic process|negative regulation of T cell proliferation|positive regulation of B cell apoptosis|positive regulation of cytokine secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|receptor biosynthetic process|regulation of isotype switching|response to glucocorticoid stimulus|type 2 immune response	extracellular space	cytokine activity|growth factor activity|interleukin-10 receptor binding				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			CCTCTCTGTCCCCCTTTTATA	0.473													6	11					0	0	0	0	T	206945859	T	T	206945859	1	4	276	0	1	0	0	0	0	0	0	0	7658	638	22	4		4	IL10	1	206945859	5'Flank	SNP	C	TCGA-D6-6516-01A-11D-1870-08	124527	206945859	42304762	158	50047											
CR2	1380	broad.mit.edu	37	chr1	207640107	207640107	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgagcccatagtaccaggaGgatacaaaattagaggctct	14	8	10	9	0	1	2	0	1	1	1	1	4	1	4	2	3	3	2	2	3	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:207640107G>A	uc001hfw.2	+	2	389	c.295G>A	c.(295-297)GGA>AGA	p.G99R	CR2_uc001hfv.2_Missense_Mutation_p.G99R|CR2_uc009xch.2_Missense_Mutation_p.G99R	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	99	Sushi 2.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity	p.G99*(1)		upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						AGTACCAGGAGGATACAAAAT	0.408													27	35					0	0	0	0	A	207640107	A	A	207640107	3	1	276	1	0	0	0	0	1	0	0	0	3857	1001	35	4	301	4	CR2	1	207640107	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	694248	207640107	41610514	159	50048											
TRAF3IP3	80342	broad.mit.edu	37	chr1	209936417	209936418	+	Missense_Mutation	DNP	GG	AA	AA																															tttcttctctttccagttacGgagttgcagttctggataag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:209936417_209936418GG>AA	uc001hho.2	+	6	846_847	c.556_557GG>AA	c.(556-558)GGA>AAA	p.G186K	TRAF3IP3_uc001hhl.2_Missense_Mutation_p.G166K|TRAF3IP3_uc001hhm.1_Missense_Mutation_p.G186K|TRAF3IP3_uc001hhn.2_Missense_Mutation_p.G166K|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.G186K	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	186	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		TTCCAGTTACGGAGTTGCAGTT	0.406													5	46					0	0	0	0	AA	209936418	AA	AA	209936417	3	1	276	1	0	0	0	0	1	0	0	0	16509	1117	39	1	570	1	TRAF3IP3	1	209936417	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	2296310	209936417	39314204	160	50049											
C1orf74	148304	broad.mit.edu	37	chr1	209956454	209956455	+	Missense_Mutation	DNP	GG	AA	AA																															gggaacaggatagcccaggaGgatcccaaatacagtacaca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:209956454_209956455GG>AA	uc001hhp.1	-	2	768_769	c.525_526CC>TT	c.(523-528)ATCCTC>ATTTTC	p.L176F		NM_152485	NP_689698	Q96LT6	CA074_HUMAN	hypothetical protein LOC148304	176										skin(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0328)		TAGCCCAGGAGGATCCCAAATA	0.505													44	58					0	0	0	0	AA	209956455	AA	AA	209956454	3	1	276	1	0	0	0	0	1	0	0	0	2068	1000	35	4	287	4	C1orf74	1	209956454	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	20037	209956454	39294167	161	50050											
RPS6KC1	26750	broad.mit.edu	37	chr1	213414910	213414910	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcttgtaaatttacctggTgaattggagtcaacaagaga	13	13	9	6	0	2	2	1	1	1	1	2	4	2	3	1	2	2	1	1	2	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:213414910T>G	uc010ptr.1	+	11	2250	c.2091T>G	c.(2089-2091)GGT>GGG	p.G697G	RPS6KC1_uc001hkd.2_Silent_p.G685G|RPS6KC1_uc010pts.1_Silent_p.G485G|RPS6KC1_uc010ptt.1_Silent_p.G485G|RPS6KC1_uc010ptu.1_Silent_p.G516G|RPS6KC1_uc010ptv.1_Silent_p.G232G|RPS6KC1_uc001hke.2_Silent_p.G516G	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	697					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		ATTTACCTGGTGAATTGGAGT	0.388													18	67					0	0	0	0	G	213414910	G	G	213414910	2	3	276	1	0	0	0	0	0	0	0	1	13723	1683	59	5		5	RPS6KC1	1	213414910	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	3458456	213414910	35835711	162	50051											
PROX1	5629	broad.mit.edu	37	chr1	214171352	214171352	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccttcccttgatggcctatCcatttcagagcccattaggt	7	13	7	14	0	1	2	1	1	0	1	3	2	3	2	5	2	1	0	5	2	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:214171352C>T	uc001hkh.2	+	2	1746	c.1474C>T	c.(1474-1476)CCA>TCA	p.P492S	PROX1_uc001hkg.1_Missense_Mutation_p.P492S	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	492					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GATGGCCTATCCATTTCAGAG	0.592													16	70					0	0	0	0	T	214171352	T	T	214171352	3	4	276	1	0	0	0	0	1	0	0	0	12622	855	30	2	1476	2	PROX1	1	214171352	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	756442	214171352	35079269	163	50052											
PTPN14	5784	broad.mit.edu	37	chr1	214625317	214625317	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaggccaaagtagtgcgTctagataaaagggtaaaata	18	7	10	6	1	1	1	0	0	1	1	1	1	1	1	2	2	1	2	2	2	9	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:214625317T>G	uc001hkk.1	-	3	446	c.175A>C	c.(175-177)ACG>CCG	p.T59P	PTPN14_uc010pty.1_5'UTR	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	59	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		AAGTAGTGCGTCTAGATAAAA	0.488													16	49					0	0	0	0	G	214625317	G	G	214625317	3	3	276	1	0	0	0	0	1	0	0	0	12846	1681	58	5	3456	5	PTPN14	1	214625317	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	453965	214625317	34625304	164	50053											
USH2A	7399	broad.mit.edu	37	chr1	215808040	215808040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttcccaggagttgttaggaCcaagcctgcaaaacccagag	12	8	10	11	0	0	1	0	0	0	1	1	3	1	3	4	2	3	3	4	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:215808040C>T	uc001hku.1	-	70	15445	c.15058G>A	c.(15058-15060)GTC>ATC	p.V5020I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	5020	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTTGTTAGGACCAAGCCTGCA	0.443										HNSCC(13;0.011)			10	73					0	0	0	0	T	215808040	T	T	215808040	3	4	276	1	0	0	0	0	1	0	0	0	17104	507	18	4	562	4	USH2A	1	215808040	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1182723	215808040	33442581	165	50054											
USH2A	7399	broad.mit.edu	37	chr1	216380737	216380737	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattgatagcagaagaacttTgaacttgtcctctgggcgga	11	11	12	7	1	1	4	0	2	1	2	2	6	2	5	1	2	3	1	1	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:216380737T>C	uc001hku.1	-	16	3581	c.3194A>G	c.(3193-3195)CAA>CGA	p.Q1065R	USH2A_uc001hkv.2_Missense_Mutation_p.Q1065R	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1065	Extracellular (Potential).|Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGAAGAACTTTGAACTTGTCC	0.413										HNSCC(13;0.011)			14	67					0	0	0	0	C	216380737	C	C	216380737	3	2	276	1	0	0	0	0	1	0	0	0	17104	1812	63	5	12656	5	USH2A	1	216380737	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	572697	216380737	32869884	166	50055											
ESRRG	2104	broad.mit.edu	37	chr1	216680458	216680458	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctggccagcttcataatcCtgcagcgcttcatgtaagac	9	11	9	12	1	2	1	2	0	0	1	3	1	3	1	2	1	4	5	2	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:216680458C>T	uc001hkw.1	-	7	1366	c.1200G>A	c.(1198-1200)CAG>CAA	p.Q400Q	ESRRG_uc001hky.1_Silent_p.Q377Q|ESRRG_uc009xdp.1_Silent_p.Q377Q|ESRRG_uc001hkz.1_Silent_p.Q338Q|ESRRG_uc010puc.1_Silent_p.Q377Q|ESRRG_uc001hla.1_Silent_p.Q377Q|ESRRG_uc001hlb.1_Silent_p.Q377Q|ESRRG_uc010pud.1_Silent_p.Q208Q|ESRRG_uc001hlc.1_Silent_p.Q377Q|ESRRG_uc001hld.1_Silent_p.Q377Q|ESRRG_uc001hkx.1_Silent_p.Q412Q|ESRRG_uc009xdo.1_Silent_p.Q377Q	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	400					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CTTCATAATCCTGCAGCGCTT	0.498													14	51					0	0	0	0	T	216680458	T	T	216680458	2	4	276	1	0	0	0	0	0	0	0	1	5286	680	24	4		4	ESRRG	1	216680458	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	299721	216680458	32570163	167	50056											
MARK1	4139	broad.mit.edu	37	chr1	220791840	220791840	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagtctgggcgtcattctCtatacattagtcagtggctc	7	14	11	9	1	4	0	2	0	2	0	6	1	4	1	0	3	1	1	0	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:220791840C>T	uc001hmn.3	+	8	1338	c.741C>T	c.(739-741)CTC>CTT	p.L247L	MARK1_uc009xdw.2_Silent_p.L247L|MARK1_uc010pun.1_Silent_p.L247L|MARK1_uc001hmm.3_Silent_p.L225L	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	247	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		GCGTCATTCTCTATACATTAG	0.428													14	65					0	0	0	0	T	220791840	T	T	220791840	2	4	276	1	0	0	0	0	0	0	0	1	9365	900	32	2		2	MARK1	1	220791840	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4111382	220791840	28458781	168	50057											
DUSP10	11221	broad.mit.edu	37	chr1	221879775	221879775	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagggagttgtcacagaggTtttcatggttctgcttaaaa	10	13	13	5	0	3	1	2	0	1	1	3	3	3	3	0	4	1	4	0	4	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:221879775T>C	uc001hmy.1	-	3	1027	c.845A>G	c.(844-846)AAC>AGC	p.N282S	DUSP10_uc001hmx.1_5'UTR|DUSP10_uc001hmz.1_5'UTR	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	282	Rhodanese.				inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		GTCACAGAGGTTTTCATGGTT	0.572													30	71					0	0	0	0	C	221879775	C	C	221879775	3	2	276	1	0	0	0	0	1	0	0	0	4832	1725	60	5	611	5	DUSP10	1	221879775	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1087935	221879775	27370846	169	50058											
HHIPL2	79802	broad.mit.edu	37	chr1	222717466	222717466	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taatcagagcagaggcccggGagattccggagaggcgtctg	10	6	16	9	3	2	4	1	0	1	4	3	6	3	4	2	4	1	1	2	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:222717466G>A	uc001hnh.1	-	2	445	c.387C>T	c.(385-387)CTC>CTT	p.L129L		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	129					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		AGAGGCCCGGGAGATTCCGGA	0.577													33	153					0	0	0	0	A	222717466	A	A	222717466	2	1	276	1	0	0	0	0	0	0	0	1	7133	1161	41	2		2	HHIPL2	1	222717466	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	837691	222717466	26533155	170	50059											
WNT3A	89780	broad.mit.edu	37	chr1	228246955	228246955	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcgcccaacttctgcgagcCcaaccctgagacgggctcct	7	7	9	18	3	1	1	0	1	1	1	3	3	2	1	4	1	4	1	4	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:228246955C>T	uc001hrq.1	+	4	926	c.848C>T	c.(847-849)CCC>CTC	p.P283L	WNT3A_uc001hrp.1_Missense_Mutation_p.P283L	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	283					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)				TTCTGCGAGCCCAACCCTGAG	0.701													6	12					0	0	0	0	T	228246955	T	T	228246955	3	4	276	1	0	0	0	0	1	0	0	0	17457	623	22	4	862	4	WNT3A	1	228246955	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5529489	228246955	21003666	171	50060											
C1orf69	200205	broad.mit.edu	37	chr1	228362983	228362983	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcatccgcaagcgcctcttCcctgtccggttcttggaccc	4	11	9	17	3	3	0	1	0	2	0	6	1	6	1	5	2	1	2	5	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:228362983C>T	uc001hsl.3	+	3	929	c.840C>T	c.(838-840)TTC>TTT	p.F280F	C1orf69_uc010pvw.1_Silent_p.F87F	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	280					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				AGCGCCTCTTCCCTGTCCGGT	0.637													10	56					0	0	0	0	T	228362983	T	T	228362983	2	4	276	1	0	0	0	0	0	0	0	1	2067	854	30	2		2	C1orf69	1	228362983	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	116028	228362983	20887638	172	50061											
C1orf198	84886	broad.mit.edu	37	chr1	230979405	230979405	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggctaggggtcagcgactGgaactcggcctcaggcccct	6	7	14	14	2	2	0	2	0	0	0	3	2	2	1	3	6	2	1	3	6	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:230979405G>A	uc001hub.2	-	3	666	c.622C>T	c.(622-624)CAG>TAG	p.Q208*	C1orf198_uc009xfh.1_Nonsense_Mutation_p.Q78*|C1orf198_uc001huc.1_5'UTR|C1orf198_uc001hud.1_Nonsense_Mutation_p.Q170*	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	208											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GTCAGCGACTGGAACTCGGCC	0.637													18	75					0	0	0	0	A	230979405	A	A	230979405	4	1	276	1	0	0	0	0	0	1	0	0	2035	1357	47	4	369	4	C1orf198	1	230979405	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2616422	230979405	18271216	173	50062											
SIPA1L2	57568	broad.mit.edu	37	chr1	232649796	232649797	+	Missense_Mutation	DNP	GT	TG	TG																															ccagaactgaaagaggatgaGttggctcgagagagcgcaat																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:232649796_232649797GT>TG	uc001hvg.2	-	1	1447_1448	c.1289_1290AC>CA	c.(1288-1290)AAC>ACA	p.N430T		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	430					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AAGAGGATGAGTTGGCTCGAGA	0.515													30	139					0	0	0	0	TG	232649797	TG	TG	232649796	3	4	276	1	0	0	0	0	1	0	0	0	14395	1020	36	4	3962	4	SIPA1L2	1	232649796	Missense_Mutation	DNP	GT	TCGA-D6-6516-01A-11D-1870-08	1670391	232649796	16600825	174	50063											
TARBP1	6894	broad.mit.edu	37	chr1	234584226	234584226	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaattacagaaacaattacCtatactgagtcttcattcct	14	14	3	10	0	3	2	2	1	1	1	4	2	4	2	2	0	4	0	2	0	7	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:234584226C>T	uc001hwd.2	-	11	1961	c.1961G>A	c.(1960-1962)AGC>AAC	p.S654N		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	654					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			AAACAATTACCTATACTGAGT	0.373													8	39					0	0	0	0	T	234584226	T	T	234584226	3	4	276	1	0	0	0	0	1	0	0	0	15621	695	24	4	2984	4	TARBP1	1	234584226	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1934430	234584226	14666395	175	50064											
B3GALNT2	148789	broad.mit.edu	37	chr1	235643460	235643460	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgaagcgagcaatgaagagGgcctcctacaaattgggaga	14	6	13	8	1	0	4	0	2	0	2	1	6	1	4	2	2	3	1	2	2	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:235643460G>A	uc001hxc.2	-	5	790	c.561C>T	c.(559-561)GCC>GCT	p.A187A	B3GALNT2_uc001hxd.1_Silent_p.A228A	NM_152490	NP_689703	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	187	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			breast(1)	1	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			CAATGAAGAGGGCCTCCTACA	0.423													12	46					0	0	0	0	A	235643460	A	A	235643460	2	1	276	1	0	0	0	0	0	0	0	1	1248	1219	43	4		4	B3GALNT2	1	235643460	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1059234	235643460	13607161	176	50065											
RYR2	6262	broad.mit.edu	37	chr1	237540664	237540664	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacaccctgcctctaagcagCgatcagaaggagaaaaagta	16	6	9	10	1	2	2	1	0	1	2	2	4	2	2	2	1	4	2	2	1	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:237540664C>T	uc001hyl.1	+	8	625	c.505C>T	c.(505-507)CGA>TGA	p.R169*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	169	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTCTAAGCAGCGATCAGAAGG	0.418													4	35					0	0	0	0	T	237540664	T	T	237540664	4	4	276	1	0	0	0	0	0	1	0	0	13834	760	27	1	535	1	RYR2	1	237540664	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1897204	237540664	11709957	177	50066											
RYR2	6262	broad.mit.edu	37	chr1	237754053	237754053	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttatcgcctgagcatgccGatcgagtgcgcggaggtctt	6	12	13	10	5	1	1	0	1	1	0	3	4	1	2	2	2	3	1	2	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:237754053G>A	uc001hyl.1	+	31	4041	c.3921G>A	c.(3919-3921)CCG>CCA	p.P1307P		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1307	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGAGCATGCCGATCGAGTGCG	0.507													42	143					0	0	0	0	A	237754053	A	A	237754053	2	1	276	1	0	0	0	0	0	0	0	1	13834	1045	37	1		1	RYR2	1	237754053	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	213389	237754053	11496568	178	50067											
RYR2	6262	broad.mit.edu	37	chr1	237777850	237777850	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agggcagtcttcatgcccggGacccagttggagggactact	8	8	14	11	1	2	0	1	0	1	0	2	3	2	3	2	4	2	2	2	4	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:237777850G>A	uc001hyl.1	+	37	5542	c.5422G>A	c.(5422-5424)GAC>AAC	p.D1808N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1808	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCATGCCCGGGACCCAGTTGG	0.478													45	168					0	0	0	0	A	237777850	A	A	237777850	3	1	276	1	0	0	0	0	1	0	0	0	13834	1174	41	2	5568	2	RYR2	1	237777850	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	23797	237777850	11472771	179	50068											
RYR2	6262	broad.mit.edu	37	chr1	237804216	237804216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgacacagaggaggaggaaGatgacactatccacatgggg	14	5	15	7	0	0	4	0	2	0	2	1	7	1	7	1	5	0	0	1	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:237804216G>A	uc001hyl.1	+	47	7255	c.7135G>A	c.(7135-7137)GAT>AAT	p.D2379N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2379	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGAGGAGGAAGATGACACTAT	0.428													7	27					0	0	0	0	A	237804216	A	A	237804216	3	1	276	1	0	0	0	0	1	0	0	0	13834	942	33	2	7321	2	RYR2	1	237804216	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	26366	237804216	11446405	180	50069											
RYR2	6262	broad.mit.edu	37	chr1	237837398	237837398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcctgacatactcttaggaGgaggaaaccatcctctgctg	10	10	10	11	0	2	1	0	1	2	0	4	4	4	4	3	3	3	1	3	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:237837398G>A	uc001hyl.1	+	59	8713	c.8593G>A	c.(8593-8595)GGA>AGA	p.G2865R	RYR2_uc010pxz.1_5'Flank	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2865	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.|4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACTCTTAGGAGGAGGAAACCA	0.408													16	83					0	0	0	0	A	237837398	A	A	237837398	3	1	276	1	0	0	0	0	1	0	0	0	13834	1001	35	4	8827	4	RYR2	1	237837398	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	33182	237837398	11413223	181	50070											
RYR2	6262	broad.mit.edu	37	chr1	237947405	237947405	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcctgaattatttccagccCtttctgggccgcatcgaaat	8	13	8	12	2	1	1	0	1	1	0	4	2	3	1	4	1	1	1	4	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:237947405C>G	uc001hyl.1	+	90	12513	c.12393C>G	c.(12391-12393)CCC>CCG	p.P4131P	RYR2_uc010pya.1_Silent_p.P546P	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4131					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATTTCCAGCCCTTTCTGGGCC	0.527													11	50					0	0	0	0	G	237947405	G	G	237947405	2	3	276	1	0	0	0	0	0	0	0	1	13834	668	24	4		4	RYR2	1	237947405	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	110007	237947405	11303216	182	50071											
CEP170	9859	broad.mit.edu	37	chr1	243289829	243289829	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atactgaaatcagcctcagaTtcagcattctcaaattcagc	14	11	5	11	0	5	2	5	1	1	1	6	2	5	2	1	0	4	1	1	0	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:243289829T>C	uc001hzs.2	-	20	5085	c.4677A>G	c.(4675-4677)GAA>GAG	p.E1559E	CEP170_uc001hzt.2_Silent_p.E1435E|CEP170_uc001hzu.2_Silent_p.E1461E|CEP170_uc001hzr.2_Silent_p.E148E|CEP170_uc001hzv.1_Intron	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1559	Targeting to microtubules.|Targeting to centrosomes.					centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CAGCCTCAGATTCAGCATTCT	0.458													6	18					0	0	0	0	C	243289829	C	C	243289829	2	2	276	1	0	0	0	0	0	0	0	1	3265	1490	52	5		5	CEP170	1	243289829	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	5342424	243289829	5960792	183	50072											
ZNF695	57116	broad.mit.edu	37	chr1	247163359	247163359	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagaattctagagccacatcCctgaatgccaatagtccctg	12	9	8	12	0	1	3	0	1	1	2	3	4	3	3	4	0	2	0	4	0	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:247163359C>T	uc009xgu.2	-	2	166	c.21G>A	c.(19-21)AGG>AGA	p.R7R	ZNF695_uc001ica.2_RNA|ZNF695_uc001icb.1_RNA|ZNF695_uc009xgt.1_RNA|ZNF695_uc001ibx.2_Silent_p.R7R|ZNF695_uc001iby.2_RNA|ZNF695_uc001icc.2_Silent_p.R7R	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	7	KRAB.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GAGCCACATCCCTGAATGCCA	0.453													9	55					0	0	0	0	T	247163359	T	T	247163359	2	4	276	1	0	0	0	0	0	0	0	1	18165	622	22	4		4	ZNF695	1	247163359	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3873530	247163359	2087262	184	50073											
OR2W5	441932	broad.mit.edu	37	chr1	247655080	247655080	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctctccctcatcctcatctCctatggcgtgattgcagccg	5	12	8	16	2	4	1	2	1	2	0	7	1	5	1	4	1	2	2	4	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:247655080C>T	uc001icz.1	+	1	651	c.651C>T	c.(649-651)CTC>CTT	p.L217L		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			ATCCTCATCTCCTATGGCGTG	0.562													25	81					0	0	0	0	T	247655080	T	T	247655080	2	4	276	1	0	0	0	0	0	0	0	1	11088	842	30	2		2	OR2W5	1	247655080	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	491721	247655080	1595541	185	50074											
OR2G2	81470	broad.mit.edu	37	chr1	247752021	247752021	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtgcgtcctcccggctgtGatgtcctgtgaccgctatgt	4	12	13	12	3	0	2	0	2	0	0	3	3	3	2	4	1	1	2	4	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:247752021G>A	uc010pyy.1	+	1	360	c.360G>A	c.(358-360)GTG>GTA	p.V120V		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCCCGGCTGTGATGTCCTGTG	0.532													33	149					0	0	0	0	A	247752021	A	A	247752021	2	1	276	1	0	0	0	0	0	0	0	1	11052	1277	45	2		2	OR2G2	1	247752021	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	96941	247752021	1498600	186	50075											
OR14A16	284532	broad.mit.edu	37	chr1	247978769	247978769	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccaaggaatgaaatggagTtgttgtgtatcaaagaattg	15	11	12	3	0	1	2	1	1	0	1	1	4	1	4	1	2	1	3	1	2	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:247978769T>C	uc001idm.1	-	1	263	c.263A>G	c.(262-264)AAC>AGC	p.N88S		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGAAATGGAGTTGTTGTGTAT	0.448													8	40					0	0	0	0	C	247978769	C	C	247978769	3	2	276	1	0	0	0	0	1	0	0	0	10999	1725	60	5	670	5	OR14A16	1	247978769	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	226748	247978769	1271852	187	50076											
OR2L3	391192	broad.mit.edu	37	chr1	248224682	248224682	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgaaatctgcagaagggagGaagaaagcctacctgacctg	15	6	12	8	0	1	4	0	2	1	2	1	6	1	6	3	2	3	1	3	2	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:248224682G>A	uc001idx.1	+	1	699	c.699G>A	c.(697-699)AGG>AGA	p.R233R	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CAGAAGGGAGGAAGAAAGCCT	0.478													74	105					0	0	0	0	A	248224682	A	A	248224682	2	1	276	1	0	0	0	0	0	0	0	1	11062	1165	41	2		2	OR2L3	1	248224682	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	245913	248224682	1025939	188	50077											
OR2L13	284521	broad.mit.edu	37	chr1	248262753	248262753	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaatcaaactggaatatttCtcttgtgccttatcatcctc	11	15	4	11	0	3	0	2	0	1	0	6	1	4	1	2	1	2	0	2	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:248262753C>T	uc001ids.2	+	3	413	c.76C>T	c.(76-78)CTC>TTC	p.L26F		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TGGAATATTTCTCTTGTGCCT	0.438													56	80					0	0	0	0	T	248262753	T	T	248262753	3	4	276	1	0	0	0	0	1	0	0	0	11060	913	32	2	78	2	OR2L13	1	248262753	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	38071	248262753	987868	189	50078											
OR2M5	127059	broad.mit.edu	37	chr1	248308568	248308568	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcttttcagtggccttcaTgggaaactctgtcatggttc	7	15	9	10	0	5	0	3	0	2	0	6	1	5	1	1	3	1	1	1	3	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:248308568T>G	uc010pze.1	+	1	119	c.119T>G	c.(118-120)ATG>AGG	p.M40R		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GTGGCCTTCATGGGAAACTCT	0.522													120	183					0	0	0	0	G	248308568	G	G	248308568	3	3	276	1	0	0	0	0	1	0	0	0	11067	1464	51	5	121	5	OR2M5	1	248308568	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	45815	248308568	942053	190	50079											
OR2T12	127064	broad.mit.edu	37	chr1	248458859	248458859	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcctaggagaataaaatctgGggtagtatttctcatctcca	12	13	8	8	0	3	1	1	0	3	1	6	2	4	1	2	3	0	2	2	3	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:248458859G>A	uc010pzj.1	-	1	22	c.22C>T	c.(22-24)CCA>TCA	p.P8S		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATAAAATCTGGGGTAGTATTT	0.438													23	89					0	0	0	0	A	248458859	A	A	248458859	3	1	276	1	0	0	0	0	1	0	0	0	11073	1232	43	4	943	4	OR2T12	1	248458859	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	150291	248458859	791762	191	50080											
OR2G6	391211	broad.mit.edu	37	chr1	248685539	248685539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atacgactttcaacgaggcaGaactctttgtggccagtgta	11	11	10	9	2	2	1	1	0	1	1	2	3	2	1	1	2	3	2	1	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr1:248685539G>A	uc001ien.1	+	1	592	c.592G>A	c.(592-594)GAA>AAA	p.E198K		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAACGAGGCAGAACTCTTTGT	0.473													41	51					0	0	0	0	A	248685539	A	A	248685539	3	1	276	1	0	0	0	0	1	0	0	0	11054	943	33	2	594	2	OR2G6	1	248685539	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	226680	248685539	565082	192	50081											
TPO	7173	broad.mit.edu	37	chr2	1457507	1457507	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctccaacacggccctggcacGatggctccctccagtctatg	7	8	9	17	2	1	0	0	0	1	0	4	1	4	0	4	3	1	2	4	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:1457507G>A	uc002qww.2	+	6	615	c.524G>A	c.(523-525)CGA>CAA	p.R175Q	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.R175Q|TPO_uc002qwr.2_Missense_Mutation_p.R175Q|TPO_uc002qwx.2_Missense_Mutation_p.R175Q|TPO_uc010yio.1_Missense_Mutation_p.R175Q|TPO_uc010yip.1_Missense_Mutation_p.R175Q	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	175	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCCCTGGCACGATGGCTCCCT	0.602													38	104					0	0	0	0	A	1457507	A	A	1457507	3	1	276	1	0	0	0	0	1	0	0	0	16477	1058	37	1	542	1	TPO	2	1457507	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08		1457507	241741866	193	50082											
TPO	7173	broad.mit.edu	37	chr2	1460007	1460007	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgccttcgggggaggggctGactgccagatgacttgtgag	6	9	17	9	1	0	4	0	3	0	1	1	5	0	5	2	4	2	1	2	4	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:1460007G>A	uc002qww.2	+	7	863	c.772G>A	c.(772-774)GAC>AAC	p.D258N	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.D258N|TPO_uc002qwr.2_Missense_Mutation_p.D258N|TPO_uc002qwx.2_Missense_Mutation_p.D258N|TPO_uc010yio.1_Missense_Mutation_p.D258N|TPO_uc010yip.1_Missense_Mutation_p.D258N	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	258	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGAGGGGCTGACTGCCAGAT	0.463													4	44					0	0	0	0	A	1460007	A	A	1460007	3	1	276	1	0	0	0	0	1	0	0	0	16477	1290	45	2	794	2	TPO	2	1460007	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2500	1460007	241739366	194	50083											
TSSC1	7260	broad.mit.edu	37	chr2	3193185	3193185	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagctcagggaggcaaacaGccacgggtcagccgaggacc	12	3	14	12	2	2	0	2	0	0	0	2	3	2	2	3	4	4	2	3	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:3193185G>A	uc002qxj.2	-	9	1277	c.1084C>T	c.(1084-1086)CTG>TTG	p.L362L	TSSC1_uc002qxi.2_RNA	NM_003310	NP_003301	Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	362	WD 5.						protein binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		GAGGCAAACAGCCACGGGTCA	0.622													4	16					0	0	0	0	A	3193185	A	A	3193185	2	1	276	1	0	0	0	0	0	0	0	1	16733	962	34	4		4	TSSC1	2	3193185	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1733178	3193185	240006188	195	50084											
TTC15	51112	broad.mit.edu	37	chr2	3392406	3392406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcgtggacaaggagaacCtcaccatgccgggcctcagg	9	7	13	12	2	2	1	2	0	0	1	3	3	2	2	4	4	2	1	4	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:3392406C>T	uc002qxm.1	+	2	1218	c.1012C>T	c.(1012-1014)CTC>TTC	p.L338F	TTC15_uc002qxn.1_Missense_Mutation_p.L338F|TTC15_uc010ewm.1_Missense_Mutation_p.L338F|TTC15_uc002qxl.1_Missense_Mutation_p.L338F	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	338							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		CAAGGAGAACCTCACCATGCC	0.682													3	12					0	0	0	0	T	3392406	T	T	3392406	3	4	276	1	0	0	0	0	1	0	0	0	16750	681	24	4	1014	4	TTC15	2	3392406	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	199221	3392406	239806967	196	50085											
COLEC11	78989	broad.mit.edu	37	chr2	3691452	3691452	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	caaggacgaggctgccaatgGcctgatggccgcatacctgg	9	6	14	12	2	0	1	0	1	0	0	0	3	0	2	4	5	2	2	4	5	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:3691452G>A	uc002qya.2	+	7	708	c.560G>A	c.(559-561)GGC>GAC	p.G187D	COLEC11_uc002qxz.2_Missense_Mutation_p.G184D|COLEC11_uc002qyb.2_Missense_Mutation_p.G163D|COLEC11_uc002qyc.2_Missense_Mutation_p.G163D|COLEC11_uc010ewo.2_Missense_Mutation_p.G139D|COLEC11_uc010ewp.2_Missense_Mutation_p.G161D|COLEC11_uc010ewq.2_Missense_Mutation_p.G137D|COLEC11_uc010ewr.2_Missense_Mutation_p.G137D|COLEC11_uc010ews.2_Missense_Mutation_p.G113D	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	187	C-type lectin.					collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		GCTGCCAATGGCCTGATGGCC	0.662													4	32					0	0	0	0	A	3691452	A	A	3691452	3	1	276	1	0	0	0	0	1	0	0	0	3726	1203	42	4	665	4	COLEC11	2	3691452	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	299046	3691452	239507921	197	50086											
SOX11	6664	broad.mit.edu	37	chr2	5833795	5833795	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcagccgcctctactacagCttcaagaacatcaccaagca	13	6	7	15	1	3	1	2	0	1	1	3	1	3	1	3	1	6	3	3	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:5833795C>T	uc002qyj.2	+	1	997	c.942C>T	c.(940-942)AGC>AGT	p.S314S		NM_003108	NP_003099	P35716	SOX11_HUMAN	SRY-box 11	314					cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(3)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		TCTACTACAGCTTCAAGAACA	0.697													8	13					0	0	0	0	T	5833795	T	T	5833795	2	4	276	1	0	0	0	0	0	0	0	1	15006	796	28	4		4	SOX11	2	5833795	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2142343	5833795	237365578	198	50087											
ROCK2	9475	broad.mit.edu	37	chr2	11354483	11354483	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatataaaacatgttttacCttttccaaatcagtaaatct	17	15	2	7	0	2	0	1	0	1	0	3	0	3	0	2	0	2	2	2	0	8	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:11354483C>T	uc002rbd.1	-	17	2492	c.2043G>A	c.(2041-2043)AAG>AAA	p.K681K		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	681	Potential.|Interaction with PPP1R12A.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		CATGTTTTACCTTTTCCAAAT	0.328													20	47					0	0	0	0	T	11354483	T	T	11354483	2	4	276	1	0	0	0	0	0	0	0	1	13583	695	24	4		4	ROCK2	2	11354483	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5520688	11354483	231844890	199	50088											
GREB1	9687	broad.mit.edu	37	chr2	11750976	11750976	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactccccgaagcagtgcccCtgcggccacgggctcatggt	7	6	12	16	3	1	0	1	0	0	0	2	1	2	0	5	3	4	2	5	3	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:11750976C>T	uc002rbk.1	+	18	3129	c.2829C>T	c.(2827-2829)CCC>CCT	p.P943P	GREB1_uc002rbo.1_Silent_p.P577P|GREB1_uc002rbp.1_5'Flank	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	943						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		AGCAGTGCCCCTGCGGCCACG	0.692													11	19					0	0	0	0	T	11750976	T	T	11750976	2	4	276	1	0	0	0	0	0	0	0	1	6799	668	24	4		4	GREB1	2	11750976	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	396493	11750976	231448397	200	50089											
NTSR2	23620	broad.mit.edu	37	chr2	11802337	11802337	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaaagcagttagtgccaaGgggagcacgaaggacaccag	15	3	15	8	1	0	0	0	0	0	0	0	4	0	3	2	4	3	3	2	4	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:11802337G>A	uc002rbq.3	-	2	728	c.654C>T	c.(652-654)CCC>CCT	p.P218P		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	218	Helical; Name=5; (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	TTAGTGCCAAGGGGAGCACGA	0.647													65	140					0	0	0	0	A	11802337	A	A	11802337	2	1	276	1	0	0	0	0	0	0	0	1	10765	987	35	4		4	NTSR2	2	11802337	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	51361	11802337	231397036	201	50090											
NBAS	51594	broad.mit.edu	37	chr2	15307441	15307441	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttggtcacaattggaatCattcaccttcaagaaataag	14	13	6	8	0	5	1	4	0	1	1	5	2	5	2	1	2	0	0	1	2	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:15307441C>T	uc002rcc.1	-	52	6873	c.6847G>A	c.(6847-6849)GAT>AAT	p.D2283N	NBAS_uc002rcb.1_Missense_Mutation_p.D123N|NBAS_uc010exl.1_Missense_Mutation_p.D1355N|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	2283										ovary(2)|liver(1)|skin(1)	4						CAATTGGAATCATTCACCTTC	0.517													8	36					0	0	0	0	T	15307441	T	T	15307441	3	4	276	1	0	0	0	0	1	0	0	0	10239	826	29	2	272	2	NBAS	2	15307441	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3505104	15307441	227891932	202	50091											
WDR35	57539	broad.mit.edu	37	chr2	20131060	20131060	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcctttaacttttcctcgCtgggcattcttcatctgttc	4	20	5	12	1	3	0	1	0	2	0	7	0	5	0	2	1	1	3	2	1	1	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:20131060C>A	uc002rdi.2	-	25	3075	c.2967G>T	c.(2965-2967)CAG>CAT	p.Q989H	WDR35_uc002rdj.2_Missense_Mutation_p.Q978H|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Missense_Mutation_p.Q462H	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	989										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTTTCCTCGCTGGGCATTCT	0.338													15	102					9.16793e-09	9.35232e-09	1	0	A	20131060	A	A	20131060	3	1	276	1	0	0	0	0	1	0	0	0	17357	796	28	4	594	4	WDR35	2	20131060	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4823619	20131060	223068313	203	50092											
LAPTM4A	9741	broad.mit.edu	37	chr2	20234791	20234791	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaggcagctggagtccaaGgccaggaggtcatctttgta	10	8	15	8	0	2	0	1	0	1	0	3	3	3	3	2	6	1	3	2	6	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:20234791G>A	uc002rdm.2	-	5	973	c.465C>T	c.(463-465)GCC>GCT	p.A155A	LAPTM4A_uc002rdn.2_Silent_p.A113A	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	155					transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGAGTCCAAGGCCAGGAGGT	0.428													3	9					0	0	0	0	A	20234791	A	A	20234791	2	1	276	1	0	0	0	0	0	0	0	1	8664	987	35	4		4	LAPTM4A	2	20234791	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	103731	20234791	222964582	204	50093											
RHOB	388	broad.mit.edu	37	chr2	20647719	20647719	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtgctctgccaagaccaagGaaggcgtgcgcgaggtcttc	9	7	14	11	3	2	1	0	0	2	1	3	3	2	2	2	3	3	1	2	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:20647719G>A	uc002rdv.2	+	1	885	c.493G>A	c.(493-495)GAA>AAA	p.E165K		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	165					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		CAAGACCAAGGAAGGCGTGCG	0.662													20	101					0	0	0	0	A	20647719	A	A	20647719	3	1	276	1	0	0	0	0	1	0	0	0	13397	1175	41	2	495	2	RHOB	2	20647719	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	412928	20647719	222551654	205	50094											
APOB	338	broad.mit.edu	37	chr2	21265245	21265245	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccataccttgcagttgatCctggtggcacttcttgaatc	7	14	8	12	0	1	2	0	2	1	0	4	2	3	2	3	2	2	3	3	2	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:21265245C>T	uc002red.2	-	3	353	c.225G>A	c.(223-225)AGG>AGA	p.R75R		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	75	Vitellogenin.|Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGCAGTTGATCCTGGTGGCAC	0.587													19	92					0	0	0	0	T	21265245	T	T	21265245	2	4	276	1	0	0	0	0	0	0	0	1	785	854	30	2		2	APOB	2	21265245	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	617526	21265245	221934128	206	50095											
C2orf44	80304	broad.mit.edu	37	chr2	24261404	24261404	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccttcttaaaggtcacaaGgaccaaatgtgaagaatctt	14	11	8	8	0	3	2	1	1	2	1	3	3	3	3	2	2	1	0	2	2	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:24261404G>A	uc002rep.2	-	2	1092	c.961C>T	c.(961-963)CTT>TTT	p.L321F	C2orf44_uc010eya.2_Missense_Mutation_p.L321F	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	321							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGGTCACAAGGACCAAATGT	0.388													11	61					0	0	0	0	A	24261404	A	A	24261404	3	1	276	1	0	0	0	0	1	0	0	0	2178	1000	35	4	1216	4	C2orf44	2	24261404	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2996159	24261404	218937969	207	50096											
ITSN2	50618	broad.mit.edu	37	chr2	24433775	24433775	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgctcgagggccagctttagGgaggaatggtctgcatggct	7	9	16	9	2	1	0	0	0	1	0	2	3	1	2	1	5	2	4	1	5	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:24433775G>A	uc002rfe.2	-	34	4389	c.4131C>T	c.(4129-4131)TCC>TCT	p.S1377S	ITSN2_uc002rff.2_Silent_p.S1350S	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1377	DH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAGCTTTAGGGAGGAATGGT	0.597													20	56					0	0	0	0	A	24433775	A	A	24433775	2	1	276	1	0	0	0	0	0	0	0	1	7966	1219	43	4		4	ITSN2	2	24433775	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	172371	24433775	218765598	208	50097											
DNMT3A	1788	broad.mit.edu	37	chr2	25457168	25457169	+	Missense_Mutation	DNP	CC	TT	TT																															ttacacacacgcaaaatactCcttcagcggagcgaagaggt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:25457168_25457169CC>TT	uc002rgc.2	-	23	2975_2976	c.2718_2719GG>AA	c.(2716-2721)AAGGAG>AAAAAG	p.E907K	DNMT3A_uc002rgd.2_Missense_Mutation_p.E907K|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.E718K	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	907					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCAAAATACTCCTTCAGCGGAG	0.495			Mis|F|N|S		AML								13	78					0	0	0	0	TT	25457169	TT	TT	25457168	3	4	276	1	0	0	0	0	1	0	0	0	4698	864	30	2	23	2	DNMT3A	2	25457168	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1023393	25457168	217742205	209	50098											
DNMT3A	1788	broad.mit.edu	37	chr2	25469512	25469512	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggtggctccaggcccttaGggccagaaggctggaagccc	7	6	15	13	0	0	1	0	0	0	1	1	2	1	2	4	6	1	2	4	6	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:25469512G>A	uc002rgc.2	-	10	1513	c.1256C>T	c.(1255-1257)CCT>CTT	p.P419L	DNMT3A_uc002rgd.2_Missense_Mutation_p.P419L|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.P230L	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	419					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGCCCTTAGGGCCAGAAGG	0.617			Mis|F|N|S		AML								8	61					0	0	0	0	A	25469512	A	A	25469512	3	1	276	1	0	0	0	0	1	0	0	0	4698	1000	35	4	1538	4	DNMT3A	2	25469512	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	12344	25469512	217729861	210	50099											
ASXL2	55252	broad.mit.edu	37	chr2	26029098	26029098	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccccaacaaaatatttacCttcaaagtatatactcccat	15	12	1	13	0	1	0	1	0	0	0	3	0	3	0	4	0	3	1	4	0	9	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:26029098C>T	uc002rgs.2	-	3	473	c.252G>A	c.(250-252)AAG>AAA	p.K84K		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	84					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAATATTTACCTTCAAAGTAT	0.393													9	21					0	0	0	0	T	26029098	T	T	26029098	2	4	276	1	0	0	0	0	0	0	0	1	1069	695	24	4		4	ASXL2	2	26029098	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	559586	26029098	217170275	211	50100											
KIF3C	3797	broad.mit.edu	37	chr2	26203352	26203352	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcgctcaccaggctgcGgtcatcctggatggctgcct	4	10	11	16	2	2	0	2	0	0	0	5	1	4	1	4	4	2	3	4	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:26203352G>C	uc002rgu.2	-	1	2092	c.1435C>G	c.(1435-1437)CGC>GGC	p.R479G	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.R479G	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	479	Potential.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCAGGCTGCGGTCATCCTGG	0.607													27	71					0	0	0	0	C	26203352	C	C	26203352	3	2	276	1	0	0	0	0	1	0	0	0	8341	1116	39	3	978	3	KIF3C	2	26203352	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	174254	26203352	216996021	212	50101											
DPYSL5	56896	broad.mit.edu	37	chr2	27147884	27147884	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgctgtgattacgccctcCacgtggggatcacctggtgg	5	11	13	12	2	2	1	1	1	1	0	3	2	3	2	3	4	2	1	3	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:27147884C>T	uc002rhu.3	+	3	549	c.391C>T	c.(391-393)CAC>TAC	p.H131Y	DPYSL5_uc002rhv.3_Missense_Mutation_p.H131Y	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	131					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTACGCCCTCCACGTGGGGAT	0.612													8	32					0	0	0	0	T	27147884	T	T	27147884	3	4	276	1	0	0	0	0	1	0	0	0	4772	594	21	4	397	4	DPYSL5	2	27147884	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	944532	27147884	216051489	213	50102											
EMILIN1	11117	broad.mit.edu	37	chr2	27307867	27307868	+	Missense_Mutation	DNP	GG	AA	AA																															ctcttctcacaggtcctcaaGgtgaacagggtgagtgcctt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:27307867_27307868GG>AA	uc002rii.3	+	6	2994_2995	c.2566_2567GG>AA	c.(2566-2568)GGT>AAT	p.G856N	EMILIN1_uc002rik.3_Missense_Mutation_p.G91N|KHK_uc002ril.2_5'Flank|KHK_uc002rim.2_5'Flank|KHK_uc002rin.2_5'Flank|KHK_uc002rio.2_5'Flank	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	856	Collagen-like.|Potential.				cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGTCCTCAAGGTGAACAGGGT	0.431													36	103					0	0	0	0	AA	27307868	AA	AA	27307867	3	1	276	1	0	0	0	0	1	0	0	0	5117	1000	35	4	2588	4	EMILIN1	2	27307867	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	159983	27307867	215891506	214	50103											
SLC30A3	7781	broad.mit.edu	37	chr2	27479726	27479726	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agggcacagatggagaagagGaaggtgctgatggggtcggc	11	5	20	5	1	0	4	0	1	0	3	1	6	0	5	0	7	1	2	0	7	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:27479726G>A	uc002rjk.2	-	6	999	c.813C>T	c.(811-813)TTC>TTT	p.F271F	SLC30A3_uc002rjj.2_Missense_Mutation_p.S117F|SLC30A3_uc010ylh.1_Silent_p.F266F	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	271	Helical; (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGAGAAGAGGAAGGTGCTGA	0.572													10	29					0	0	0	0	A	27479726	A	A	27479726	2	1	276	1	0	0	0	0	0	0	0	1	14620	1165	41	2		2	SLC30A3	2	27479726	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	171859	27479726	215719647	215	50104											
SLC30A3	7781	broad.mit.edu	37	chr2	27481075	27481075	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgcgggtggctggacgggtGgagagccagagggagaagag	9	4	23	5	2	0	4	0	0	0	4	0	7	0	5	1	6	2	1	1	6	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:27481075G>A	uc002rjk.2	-	3	564	c.378C>T	c.(376-378)TCC>TCT	p.S126S	SLC30A3_uc002rjj.2_5'UTR|SLC30A3_uc010ylh.1_Silent_p.S121S	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	126	Helical; (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGACGGGTGGAGAGCCAGA	0.637													23	53					0	0	0	0	A	27481075	A	A	27481075	2	1	276	1	0	0	0	0	0	0	0	1	14620	1335	47	4		4	SLC30A3	2	27481075	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1349	27481075	215718298	216	50105											
SNX17	9784	broad.mit.edu	37	chr2	27599207	27599207	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccggcgggtggggggtactCtgagacgctcagacagccag	7	5	18	11	3	2	2	1	1	1	2	2	3	2	2	2	5	2	2	2	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:27599207C>T	uc002rkg.1	+	13	1432	c.1210C>T	c.(1210-1212)CTG>TTG	p.L404L	SNX17_uc010ylj.1_Silent_p.L384L|SNX17_uc010ylk.1_Silent_p.L190L|SNX17_uc010eza.1_Silent_p.L190L|SNX17_uc002rki.1_RNA|SNX17_uc002rkh.1_Silent_p.L190L|SNX17_uc010yll.1_Silent_p.L190L|SNX17_uc010ylm.1_Silent_p.L190L|SNX17_uc010yln.1_Silent_p.L392L|SNX17_uc010ylo.1_Silent_p.L322L|SNX17_uc010ylp.1_Silent_p.L379L|SNX17_uc010ylq.1_Silent_p.L190L	NM_014748	NP_055563	Q15036	SNX17_HUMAN	sorting nexin 17	404					cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGGGGTACTCTGAGACGCTC	0.602													42	99					0	0	0	0	T	27599207	T	T	27599207	2	4	276	1	0	0	0	0	0	0	0	1	14952	912	32	2		2	SNX17	2	27599207	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	118132	27599207	215600166	217	50106											
FAM179A	165186	broad.mit.edu	37	chr2	29259474	29259474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaaccagtgggcgctggagtCcttcgccaagatgatccccc	8	7	12	14	2	0	2	0	1	0	1	3	4	2	3	5	2	1	1	5	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:29259474C>T	uc010ezl.2	+	18	2837	c.2486C>T	c.(2485-2487)TCC>TTC	p.S829F	FAM179A_uc010ymm.1_Missense_Mutation_p.S774F|FAM179A_uc002rmr.3_Missense_Mutation_p.S356F|FAM179A_uc002rms.1_Missense_Mutation_p.S127F	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	829							binding			ovary(3)|skin(1)	4						GCGCTGGAGTCCTTCGCCAAG	0.512													13	57					0	0	0	0	T	29259474	T	T	29259474	3	4	276	1	0	0	0	0	1	0	0	0	5533	855	30	2	2552	2	FAM179A	2	29259474	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1660267	29259474	213939899	218	50107											
CDKL4	344387	broad.mit.edu	37	chr2	39406422	39406422	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggagctctccaggagttggGaacaggttaatctgtcatct	10	11	12	8	0	4	0	1	0	3	0	5	3	4	3	1	4	2	3	1	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:39406422G>A	uc002rrm.2	-	8	833	c.833C>T	c.(832-834)TCC>TTC	p.S278F	CDKL4_uc010fal.1_Missense_Mutation_p.S278F	NM_001009565	NP_001009565	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4	278	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			ovary(1)	1		all_hematologic(82;0.248)				CAGGAGTTGGGAACAGGTTAA	0.433													16	105					0	0	0	0	A	39406422	A	A	39406422	3	1	276	1	0	0	0	0	1	0	0	0	3171	1174	41	2	118	2	CDKL4	2	39406422	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	10146948	39406422	203792951	219	50108											
THADA	63892	broad.mit.edu	37	chr2	43779473	43779473	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagattttccatcaagcattTgataactagaaaaagcaaac	19	10	5	7	0	1	3	1	1	0	2	2	3	2	3	1	0	4	2	1	0	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:43779473T>A	uc002rsw.3	-	18	3032	c.2680A>T	c.(2680-2682)AAA>TAA	p.K894*	THADA_uc010far.2_Nonsense_Mutation_p.K163*|THADA_uc002rsx.3_Nonsense_Mutation_p.K894*|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Nonsense_Mutation_p.K604*|THADA_uc010fat.1_Nonsense_Mutation_p.K42*|THADA_uc002rta.2_Nonsense_Mutation_p.K604*|THADA_uc002rtb.1_Nonsense_Mutation_p.K894*	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	894	Potential.						binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				ATCAAGCATTTGATAACTAGA	0.368													10	29					0	0	0	0	A	43779473	A	A	43779473	4	1	276	1	0	0	0	0	0	1	0	0	15906	1821	63	5	3265	5	THADA	2	43779473	Nonsense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	4373051	43779473	199419900	220	50109											
PLEKHH2	130271	broad.mit.edu	37	chr2	43992618	43992618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcagcaaaaggcagcatttCaccacctctctgctccagca	12	8	6	15	0	3	0	2	0	1	0	5	0	4	0	3	1	4	5	3	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:43992618C>T	uc010yny.1	+	30	4446	c.4363C>T	c.(4363-4365)CAC>TAC	p.H1455Y		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1455						cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GGCAGCATTTCACCACCTCTC	0.483													23	74					0	0	0	0	T	43992618	T	T	43992618	3	4	276	1	0	0	0	0	1	0	0	0	12132	826	29	2	4477	2	PLEKHH2	2	43992618	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	213145	43992618	199206755	221	50110											
SIX3	6496	broad.mit.edu	37	chr2	45169459	45169460	+	Missense_Mutation	DNP	CC	TT	TT																															ggcggcggcggctccagggcCcccccggaagagttgtccat																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:45169459_45169460CC>TT	uc002run.1	+	1	423_424	c.216_217CC>TT	c.(214-219)GCCCCC>GCTTCC	p.P73S		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	73					visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				gcTCCAGGGCCCCCCCGGAAGA	0.356													9	9					0	0	0	0	TT	45169460	TT	TT	45169459	3	4	276	1	0	0	0	0	1	0	0	0	14413	610	22	4	218	4	SIX3	2	45169459	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1176841	45169459	198029914	222	50111											
KLRAQ1	129285	broad.mit.edu	37	chr2	48734518	48734518	+	Nonsense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtaagtcagtgcatttttaTgccgaggtgagtgtagattt	10	15	12	4	1	1	2	1	1	0	1	1	3	1	2	1	1	2	3	1	1	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:48734518T>G	uc002rwm.2	+	19	2264	c.2079T>G	c.(2077-2079)TAT>TAG	p.Y693*	KLRAQ1_uc002rwl.2_Nonsense_Mutation_p.Y647*|KLRAQ1_uc002rwk.2_Nonsense_Mutation_p.Y682*|KLRAQ1_uc010yok.1_Nonsense_Mutation_p.Y651*	NM_001135629	NP_001129101	Q6ZMI0	KLRAQ_HUMAN	KLRAQ motif containing 1 isoform 1	693	Potential.									ovary(1)	1						TGCATTTTTATGCCGAGGTGA	0.418													15	84					0	0	0	0	G	48734518	G	G	48734518	4	3	276	1	0	0	0	0	0	1	0	0	8452	1471	51	5	2153	5	KLRAQ1	2	48734518	Nonsense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	3565059	48734518	194464855	223	50112											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48809495	48809495	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	taaggatacactttcctgtcCcatcgcagtggatcaaggcc	10	10	9	12	1	1	0	1	0	0	0	4	2	3	2	3	3	1	1	3	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:48809495C>T	uc010yol.1	+	1	1770	c.1723C>T	c.(1723-1725)CCA>TCA	p.P575S	STON1_uc002rwo.3_Missense_Mutation_p.P575S|STON1_uc010fbm.2_Missense_Mutation_p.P575S|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.P575S|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.P575S	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	575					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CTTTCCTGTCCCATCGCAGTG	0.498													22	141					0	0	0	0	T	48809495	T	T	48809495	3	4	276	1	0	0	0	0	1	0	0	0	15383	623	22	4	1725	4	STON1-GTF2A1L	2	48809495	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	74977	48809495	194389878	224	50113											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48874001	48874001	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtggagtcagtgctcagtggTtcagctagcatggctcaaaa	10	10	13	8	0	4	0	4	0	0	0	4	1	4	1	0	3	3	5	0	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:48874001T>C	uc010yol.1	+	5	2816	c.2769T>C	c.(2767-2769)GGT>GGC	p.G923G	STON1-GTF2A1L_uc002rwp.1_Silent_p.G970G|GTF2A1L_uc002rws.1_Silent_p.G266G|GTF2A1L_uc010yom.1_Silent_p.G232G|GTF2A1L_uc002rwt.2_Silent_p.G266G	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	923					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TGCTCAGTGGTTCAGCTAGCA	0.453													20	44					0	0	0	0	C	48874001	C	C	48874001	2	2	276	1	0	0	0	0	0	0	0	1	15383	1712	60	5		5	STON1-GTF2A1L	2	48874001	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	64506	48874001	194325372	225	50114											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48906536	48906536	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggtgttatgtgttttggaggGagagactatgtatttgcaaa	10	15	14	2	0	0	1	0	0	0	1	0	4	0	3	0	3	1	4	0	3	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:48906536G>A	uc010yol.1	+	8	3410	c.3363G>A	c.(3361-3363)GGG>GGA	p.G1121G	STON1-GTF2A1L_uc002rwp.1_Silent_p.G1168G|GTF2A1L_uc002rws.1_Silent_p.G464G|GTF2A1L_uc010yom.1_Silent_p.G430G|GTF2A1L_uc002rwt.2_Intron	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	1121					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GTTTTGGAGGGAGAGACTATG	0.348													18	74					0	0	0	0	A	48906536	A	A	48906536	2	1	276	1	0	0	0	0	0	0	0	1	15383	1161	41	2		2	STON1-GTF2A1L	2	48906536	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	32535	48906536	194292837	226	50115											
FSHR	2492	broad.mit.edu	37	chr2	49381544	49381544	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaatgccagcaaagagaccaGgagcagggccataattatgc	15	5	12	9	0	0	1	0	0	0	1	0	4	0	2	3	2	4	2	3	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:49381544G>A	uc002rww.2	-	1	87	c.13C>T	c.(13-15)CTG>TTG	p.L5L	FSHR_uc002rwx.2_Silent_p.L5L|FSHR_uc010fbn.2_Silent_p.L5L|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	5					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	AAAGAGACCAGGAGCAGGGCC	0.493									Gonadal_Dysgenesis_46_XX				14	56					0	0	0	0	A	49381544	A	A	49381544	2	1	276	1	0	0	0	0	0	0	0	1	6107	991	35	4		4	FSHR	2	49381544	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	475008	49381544	193817829	227	50116											
NRXN1	9378	broad.mit.edu	37	chr2	51254989	51254989	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcatgtccctgcgcttggaCttgacctccacccacttggc	5	11	9	16	1	1	1	1	1	0	0	3	2	3	2	4	2	1	1	4	2	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:51254989C>T	uc010fbq.2	-	2	1900	c.423G>A	c.(421-423)AAG>AAA	p.K141K	NRXN1_uc002rxe.3_Silent_p.K141K|NRXN1_uc002rxd.1_Silent_p.K141K	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TGCGCTTGGACTTGACCTCCA	0.677													4	34					0	0	0	0	T	51254989	T	T	51254989	2	4	276	1	0	0	0	0	0	0	0	1	10719	564	20	4		4	NRXN1	2	51254989	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1873445	51254989	191944384	228	50117											
SPTBN1	6711	broad.mit.edu	37	chr2	54891677	54891677	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agtccagccccatcccctccCcgacctctgatcgtaaagcc	8	7	6	20	2	1	1	0	1	1	0	5	2	4	1	9	0	2	1	9	0	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:54891677C>T	uc002rxu.2	+	33	6757	c.6508C>T	c.(6508-6510)CCG>TCG	p.P2170S	SPTBN1_uc010you.1_Missense_Mutation_p.P160S	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	2170					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CATCCCCTCCCCGACCTCTGA	0.592													41	117					0	0	0	0	T	54891677	T	T	54891677	3	4	276	1	0	0	0	0	1	0	0	0	15185	623	22	4	6834	4	SPTBN1	2	54891677	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3636688	54891677	188307696	229	50118											
RTN4	57142	broad.mit.edu	37	chr2	55209756	55209756	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtacttctgaaccaactcCtcagatatagcaacttcaga	13	11	5	12	0	3	3	2	1	1	2	4	3	4	3	2	0	5	2	2	0	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:55209756C>T	uc002rye.2	-	5	3553	c.3255G>A	c.(3253-3255)GAG>GAA	p.E1085E	RTN4_uc002ryc.2_Silent_p.E92E|RTN4_uc002ryd.2_Silent_p.E879E|RTN4_uc002ryf.2_Silent_p.E285E|RTN4_uc002ryg.2_Silent_p.E266E	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	1085	Lumenal (Potential).|Reticulon.				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						GAACCAACTCCTCAGATATAG	0.383													31	62					0	0	0	0	T	55209756	T	T	55209756	2	4	276	1	0	0	0	0	0	0	0	1	13793	680	24	4		4	RTN4	2	55209756	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	318079	55209756	187989617	230	50119											
CCDC85A	114800	broad.mit.edu	37	chr2	56420170	56420171	+	Missense_Mutation	DNP	CC	TT	TT																															aagcactcaaaggacctagcCcggagcaccacaaacccttg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:56420170_56420171CC>TT	uc002rzn.2	+	2	1337_1338	c.835_836CC>TT	c.(835-837)CCG>TTG	p.P279L		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	279	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AGGACCTAGCCCGGAGCACCAC	0.644													28	71					0	0	0	0	TT	56420171	TT	TT	56420170	3	4	276	1	0	0	0	0	1	0	0	0	2872	623	22	4	841	4	CCDC85A	2	56420170	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1210414	56420170	186779203	231	50120											
BCL11A	53335	broad.mit.edu	37	chr2	60689546	60689546	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgtacatgtgtagctgctGggctcatctttacctgcaaa	8	14	10	9	0	2	0	1	0	1	0	2	0	2	0	1	1	5	7	1	1	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:60689546G>A	uc002sae.1	-	4	729	c.501C>T	c.(499-501)CCC>CCT	p.P167P	BCL11A_uc002sab.2_Silent_p.P167P|BCL11A_uc002sac.2_Silent_p.P167P|BCL11A_uc010ypi.1_Silent_p.P15P|BCL11A_uc010ypj.1_Silent_p.P133P|BCL11A_uc002sad.1_Silent_p.P15P|BCL11A_uc002saf.1_Silent_p.P133P	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	167	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGTAGCTGCTGGGCTCATCTT	0.423			T	IGH@	B-CLL								16	90					0	0	0	0	A	60689546	A	A	60689546	2	1	276	1	0	0	0	0	0	0	0	1	1365	1335	47	4		4	BCL11A	2	60689546	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4269376	60689546	182509827	232	50121											
AFTPH	54812	broad.mit.edu	37	chr2	64796332	64796332	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaagcttttgtcctccttgGgaatagacacccgaaacatt	12	11	8	10	1	0	2	0	0	0	2	2	4	2	3	3	1	2	1	3	1	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:64796332G>A	uc002sdc.2	+	3	2226	c.2194G>A	c.(2194-2196)GGA>AGA	p.G732R	AFTPH_uc002scz.2_Missense_Mutation_p.G732R|AFTPH_uc002sda.2_Missense_Mutation_p.G732R|AFTPH_uc002sdb.2_Missense_Mutation_p.G732R	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	732					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						GTCCTCCTTGGGAATAGACAC	0.423													39	65					0	0	0	0	A	64796332	A	A	64796332	3	1	276	1	0	0	0	0	1	0	0	0	364	1233	43	4	2204	4	AFTPH	2	64796332	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4106786	64796332	178403041	233	50122											
GKN2	200504	broad.mit.edu	37	chr2	69172545	69172545	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaaattcccaagatgcccagGagcccagcctttgcacagcc	11	6	9	15	0	0	1	0	0	0	1	1	3	1	2	5	1	5	1	5	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:69172545G>A	uc002sfa.2	-	6	619	c.510C>T	c.(508-510)CTC>CTT	p.L170L	GKN2_uc002sfb.3_3'UTR	NM_182536	NP_872342	Q86XP6	GKN2_HUMAN	trefoil factor interactions(z) 1 precursor	170						extracellular region					0						AGATGCCCAGGAGCCCAGCCT	0.368													39	176					0	0	0	0	A	69172545	A	A	69172545	2	1	276	1	0	0	0	0	0	0	0	1	6462	1161	41	2		2	GKN2	2	69172545	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4376213	69172545	174026828	234	50123											
GMCL1	64395	broad.mit.edu	37	chr2	70076805	70076805	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggatgttccttcaacttgtgCcttcttggaatggatcttta	7	17	9	8	0	3	0	1	0	2	0	4	3	4	3	2	3	2	1	2	3	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:70076805C>T	uc002sfu.2	+	8	1072	c.865C>T	c.(865-867)CCT>TCT	p.P289S		NM_178439	NP_848526	Q96IK5	GMCL1_HUMAN	germ cell-less	289					cell differentiation|multicellular organismal development|spermatogenesis	nuclear matrix				ovary(3)	3						TCAACTTGTGCCTTCTTGGAA	0.299													12	71					0	0	0	0	T	70076805	T	T	70076805	3	4	276	1	0	0	0	0	1	0	0	0	6522	739	26	4	895	4	GMCL1	2	70076805	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	904260	70076805	173122568	235	50124											
DYSF	8291	broad.mit.edu	37	chr2	71892332	71892332	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaccagctccgcccctccCagctcctccacctcttctgc	4	8	7	22	1	2	0	0	0	2	0	6	1	6	1	8	1	3	2	8	1	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:71892332C>T	uc002sie.2	+	46	5474	c.5098C>T	c.(5098-5100)CAG>TAG	p.Q1700*	DYSF_uc010feg.2_Nonsense_Mutation_p.Q1731*|DYSF_uc010feh.2_Nonsense_Mutation_p.Q1707*|DYSF_uc002sig.3_Nonsense_Mutation_p.Q1686*|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Nonsense_Mutation_p.Q1721*|DYSF_uc010fef.2_Nonsense_Mutation_p.Q1738*|DYSF_uc010fei.2_Nonsense_Mutation_p.Q1717*|DYSF_uc010fek.2_Nonsense_Mutation_p.Q1718*|DYSF_uc010fej.2_Nonsense_Mutation_p.Q1708*|DYSF_uc010fel.2_Nonsense_Mutation_p.Q1687*|DYSF_uc010feo.2_Nonsense_Mutation_p.Q1732*|DYSF_uc010fem.2_Nonsense_Mutation_p.Q1722*|DYSF_uc010fen.2_Nonsense_Mutation_p.Q1739*|DYSF_uc002sif.2_Nonsense_Mutation_p.Q1701*|DYSF_uc010yqy.1_Nonsense_Mutation_p.Q581*|DYSF_uc010yqz.1_Nonsense_Mutation_p.Q461*	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1700	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CCGCCCCTCCCAGCTCCTCCA	0.532													9	96					0	0	0	0	T	71892332	T	T	71892332	4	4	276	1	0	0	0	0	0	1	0	0	4881	595	21	4	5539	4	DYSF	2	71892332	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1815527	71892332	171307041	236	50125											
ALMS1	7840	broad.mit.edu	37	chr2	73680577	73680577	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgcttcaaagaaccctcttCcacgggtgtatctaatggtg	9	13	9	10	1	3	1	1	0	2	1	4	1	4	1	2	2	2	2	2	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:73680577C>T	uc002sje.1	+	10	7037	c.6926C>T	c.(6925-6927)TCC>TTC	p.S2309F	ALMS1_uc002sjf.1_Missense_Mutation_p.S2265F|ALMS1_uc002sjg.2_Missense_Mutation_p.S1695F|ALMS1_uc002sjh.1_Missense_Mutation_p.S1695F	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2307					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GAACCCTCTTCCACGGGTGTA	0.433													24	47					0	0	0	0	T	73680577	T	T	73680577	3	4	276	1	0	0	0	0	1	0	0	0	535	855	30	2	6950	2	ALMS1	2	73680577	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1788245	73680577	169518796	237	50126											
ALMS1	7840	broad.mit.edu	37	chr2	73718483	73718483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagtcgtacagccttctcttCcagacagtaacactattact	12	12	5	12	1	1	1	0	0	1	1	4	1	2	1	2	0	4	2	2	0	5	6	rs45493191		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:73718483C>T	uc002sje.1	+	12	9511	c.9400C>T	c.(9400-9402)CCA>TCA	p.P3134S	ALMS1_uc002sjf.1_Missense_Mutation_p.P3090S|ALMS1_uc002sjg.2_Missense_Mutation_p.P2520S|ALMS1_uc002sjh.1_Missense_Mutation_p.P2520S	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3132					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GCCTTCTCTTCCAGACAGTAA	0.393													20	104					0	0	0	0	T	73718483	T	T	73718483	3	4	276	1	0	0	0	0	1	0	0	0	535	855	30	2	9432	2	ALMS1	2	73718483	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	37906	73718483	169480890	238	50127											
C2orf65	130951	broad.mit.edu	37	chr2	74834236	74834236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtccacgtgctctaggattcCctttgtgacctcaacgacct	7	12	8	14	2	2	1	1	1	1	0	4	3	4	2	4	1	2	1	4	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:74834236C>T	uc002smy.2	-	4	658	c.541G>A	c.(541-543)GGA>AGA	p.G181R	C2orf65_uc010ysa.1_Missense_Mutation_p.G181R|C2orf65_uc002smz.2_Missense_Mutation_p.G181R	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	181					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						TCTAGGATTCCCTTTGTGACC	0.433													32	68					0	0	0	0	T	74834236	T	T	74834236	3	4	276	1	0	0	0	0	1	0	0	0	2194	632	22	4	1083	4	C2orf65	2	74834236	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1115753	74834236	168365137	239	50128											
REG1B	5968	broad.mit.edu	37	chr2	79312675	79312675	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcactgctcggggatccagTgtcccaggacttgtaggaga	9	8	14	10	1	0	1	0	0	0	1	3	4	2	3	2	4	2	3	2	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:79312675T>G	uc002sny.2	-	5	488	c.376A>C	c.(376-378)ACT>CCT	p.T126P	REG1B_uc010ffv.1_3'UTR	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	126	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						GGGGATCCAGTGTCCCAGGAC	0.557													11	69					0	0	0	0	G	79312675	G	G	79312675	3	3	276	1	0	0	0	0	1	0	0	0	13276	1696	59	5	132	5	REG1B	2	79312675	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	4478439	79312675	163886698	240	50129											
GGCX	2677	broad.mit.edu	37	chr2	85782639	85782639	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagagccagtgccgggacaaAtattccatggaatagccttc	13	8	10	10	1	0	1	0	0	0	1	2	3	1	3	4	2	3	0	4	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:85782639A>T	uc002sps.2	-	6	799	c.693T>A	c.(691-693)TAT>TAA	p.Y231*	GGCX_uc010yss.1_Nonsense_Mutation_p.Y70*|GGCX_uc010yst.1_Nonsense_Mutation_p.Y174*	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	231	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	GCCGGGACAAATATTCCATGG	0.473													20	59					0	0	0	0	T	85782639	T	T	85782639	4	4	276	1	0	0	0	0	0	1	0	0	6393	108	4	5	1623	5	GGCX	2	85782639	Nonsense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	6469964	85782639	157416734	241	50130											
FAHD2A	51011	broad.mit.edu	37	chr2	96072818	96072818	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaaagaacagaacgtgccCgtgcccaaggagcccatcat	13	5	10	13	2	1	2	1	0	0	2	1	3	1	3	3	1	6	1	3	1	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:96072818C>T	uc002sur.2	+	3	554	c.375C>T	c.(373-375)CCC>CCT	p.P125P	FAHD2A_uc002sus.2_Silent_p.P125P	NM_016044	NP_057128	Q96GK7	FAH2A_HUMAN	fumarylacetoacetate hydrolase domain containing	125							hydrolase activity|metal ion binding			ovary(1)	1						AGAACGTGCCCGTGCCCAAGG	0.572													11	76					0	0	0	0	T	96072818	T	T	96072818	2	4	276	1	0	0	0	0	0	0	0	1	5401	639	23	1		1	FAHD2A	2	96072818	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	10290179	96072818	147126555	242	50131											
ASTL	431705	broad.mit.edu	37	chr2	96789974	96789974	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgcagagatagggaggccGgagcggggctcctaccagtg	8	5	18	10	2	0	1	0	0	0	1	1	4	1	3	3	5	3	3	3	5	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:96789974G>A	uc010yui.1	-	9	911	c.911C>T	c.(910-912)CCG>CTG	p.P304L		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	304					proteolysis		metalloendopeptidase activity|zinc ion binding				0						TAGGGAGGCCGGAGCGGGGCT	0.632													8	13					0	0	0	0	A	96789974	A	A	96789974	3	1	276	1	0	0	0	0	1	0	0	0	1065	1116	39	1	387	1	ASTL	2	96789974	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	717156	96789974	146409399	243	50132											
NCAPH	23397	broad.mit.edu	37	chr2	97024782	97024782	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtacaaatatgtgtgttacaGggaagaaatgatttcccttg	13	13	10	5	0	0	2	0	1	0	1	1	3	1	3	1	1	2	2	1	1	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:97024782G>A	uc002svz.1	+	10	1293	c.1209_splice	c.e10-1	p.Q403_splice	NCAPH_uc010fhu.1_Splice_Site_p.Q379_splice|NCAPH_uc010fhv.1_Splice_Site_p.Q392_splice|NCAPH_uc010yum.1_Splice_Site_p.Q379_splice|NCAPH_uc010fhw.1_Splice_Site_p.Q392_splice|NCAPH_uc010yun.1_Splice_Site_p.Q267_splice|NCAPH_uc002swa.1_Splice_Site	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H						cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				GTGTGTTACAGGGAAGAAATG	0.398													11	29					0	0	0	0	A	97024782	A	A	97024782	5	1	276	1	0	0	0	0	0	0	1	0	10263	1014	35	4	1246	4	NCAPH	2	97024782	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	234808	97024782	146174591	244	50133											
SEMA4C	54910	broad.mit.edu	37	chr2	97526482	97526482	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctccccggtcctcccctcCtagttgtaagcgcacgtaac	6	9	7	19	3	0	0	0	0	0	0	4	0	4	0	7	1	2	4	7	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:97526482C>T	uc002sxh.3	-	15	2543	c.2383G>A	c.(2383-2385)GGA>AGA	p.G795R	ANKRD39_uc002sxd.3_5'Flank|SEMA4C_uc002sxf.3_Missense_Mutation_p.G295R|SEMA4C_uc002sxe.2_Missense_Mutation_p.G336R|SEMA4C_uc002sxg.3_Missense_Mutation_p.G848R	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	795	Cytoplasmic (Potential).				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						TCCTCCCCTCCTAGTTGTAAG	0.642													21	111					0	0	0	0	T	97526482	T	T	97526482	3	4	276	1	0	0	0	0	1	0	0	0	14098	690	24	4	122	4	SEMA4C	2	97526482	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	501700	97526482	145672891	245	50134											
TMEM131	23505	broad.mit.edu	37	chr2	98422128	98422128	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttttaccttctgtgagaaGgaattcataatatttaaact	14	17	5	5	0	2	1	1	1	1	1	2	3	2	2	1	1	2	0	1	1	7	9			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:98422128G>A	uc002syh.3	-	20	2323	c.2094C>T	c.(2092-2094)TCC>TCT	p.S698S		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	698						integral to membrane				ovary(4)|central_nervous_system(2)	6						TCTGTGAGAAGGAATTCATAA	0.333													36	142					0	0	0	0	A	98422128	A	A	98422128	2	1	276	1	0	0	0	0	0	0	0	1	16110	987	35	4		4	TMEM131	2	98422128	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	895646	98422128	144777245	246	50135											
MAP4K4	9448	broad.mit.edu	37	chr2	102483019	102483019	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgggtctcagagtggctcCggggaacgcttcagagtgag	7	8	16	10	2	2	3	2	1	1	2	4	4	3	4	2	4	1	2	2	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:102483019C>T	uc002tbg.2	+	18	2155	c.2100C>T	c.(2098-2100)TCC>TCT	p.S700S	MAP4K4_uc002tbc.2_Silent_p.S778S|MAP4K4_uc002tbd.2_Silent_p.S670S|MAP4K4_uc002tbe.2_Silent_p.S616S|MAP4K4_uc002tbf.2_Silent_p.S670S|MAP4K4_uc010yvy.1_Silent_p.S693S|MAP4K4_uc002tbh.2_Silent_p.S615S|MAP4K4_uc002tbi.2_Silent_p.S500S|MAP4K4_uc010yvz.1_Silent_p.S673S|MAP4K4_uc002tbk.2_Silent_p.S155S|MAP4K4_uc002tbl.2_5'UTR	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	700					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AGAGTGGCTCCGGGGAACGCT	0.542													17	37					0	0	0	0	T	102483019	T	T	102483019	2	4	276	1	0	0	0	0	0	0	0	1	9315	639	23	1		1	MAP4K4	2	102483019	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4060891	102483019	140716354	247	50136											
SLC9A4	389015	broad.mit.edu	37	chr2	103124678	103124678	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcttcctctgtctctttttCctaggaagaaaatgtttgtc	7	18	7	9	0	2	1	0	0	2	1	6	2	4	2	2	1	1	2	2	1	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:103124678C>T	uc002tbz.3	+	5	1796	c.1339C>T	c.(1339-1341)CCT>TCT	p.P447S		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	447	Extracellular (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GTCTCTTTTTCCTAGGAAGAA	0.353													11	53					0	0	0	0	T	103124678	T	T	103124678	3	4	276	1	0	0	0	0	1	0	0	0	14780	855	30	2	1357	2	SLC9A4	2	103124678	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	641659	103124678	140074695	248	50137											
GPR45	11250	broad.mit.edu	37	chr2	105859166	105859166	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctctgctggctgccccactCcgtctacagcctcctgtctg	3	11	8	19	1	3	0	0	0	3	0	5	0	5	0	6	1	4	2	6	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:105859166C>T	uc002tco.1	+	1	967	c.851C>T	c.(850-852)TCC>TTC	p.S284F		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	284	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						CTGCCCCACTCCGTCTACAGC	0.587													44	149					0	0	0	0	T	105859166	T	T	105859166	3	4	276	1	0	0	0	0	1	0	0	0	6734	855	30	2	853	2	GPR45	2	105859166	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2734488	105859166	137340207	249	50138											
GPR45	11250	broad.mit.edu	37	chr2	105859281	105859281	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagtccgtcttcaaccccatCgtctactgctggagaatcaa	11	10	7	13	2	4	1	2	0	2	1	6	2	5	1	3	1	3	1	3	1	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:105859281C>T	uc002tco.1	+	1	1082	c.966C>T	c.(964-966)ATC>ATT	p.I322I		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	322	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TCAACCCCATCGTCTACTGCT	0.547													26	83					0	0	0	0	T	105859281	T	T	105859281	2	4	276	1	0	0	0	0	0	0	0	1	6734	874	31	1		1	GPR45	2	105859281	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	115	105859281	137340092	250	50139											
RGPD4	285190	broad.mit.edu	37	chr2	108455287	108455287	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgttcagtggaattaaaccCaacacaaaaagatctggtgt	15	9	9	8	1	2	1	1	0	1	1	2	2	2	2	1	2	2	1	1	2	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:108455287C>T	uc010ywk.1	+	4	354	c.272C>T	c.(271-273)CCA>CTA	p.P91L	RGPD4_uc002tdu.2_5'UTR	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	91	TPR 1.				intracellular transport		binding			skin(2)	2						GAATTAAACCCAACACAAAAA	0.254													34	31					0	0	0	0	T	108455287	T	T	108455287	3	4	276	1	0	0	0	0	1	0	0	0	13353	594	21	4	286	4	RGPD4	2	108455287	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2596006	108455287	134744086	251	50140											
SLC5A7	60482	broad.mit.edu	37	chr2	108614398	108614398	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgggagggctctattctgtgGcctacactgatgtcgttcag	6	13	13	9	1	3	1	1	1	2	0	4	2	3	2	1	3	1	2	1	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:108614398G>T	uc002tdv.2	+	5	829	c.553G>T	c.(553-555)GCC>TCC	p.A185S	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.A185S|SLC5A7_uc010ywn.1_Missense_Mutation_p.A72S	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	185	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CTATTCTGTGGCCTACACTGA	0.453													85	125					6.8793e-45	7.18825e-45	1	0	T	108614398	T	T	108614398	3	4	276	1	0	0	0	0	1	0	0	0	14734	1203	42	4	567	4	SLC5A7	2	108614398	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	159111	108614398	134584975	252	50141											
SLC5A7	60482	broad.mit.edu	37	chr2	108626920	108626920	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctcttcctgagaataactgGaggggagccatatctgtatc	10	11	10	10	0	2	1	0	1	2	1	4	4	3	3	3	3	2	1	3	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:108626920G>A	uc002tdv.2	+	9	1622	c.1346G>A	c.(1345-1347)GGA>GAA	p.G449E	SLC5A7_uc010ywm.1_Missense_Mutation_p.G202E|SLC5A7_uc010fjj.2_Missense_Mutation_p.G449E|SLC5A7_uc010ywn.1_Missense_Mutation_p.G336E	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	449	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	AGAATAACTGGAGGGGAGCCA	0.433													22	59					0	0	0	0	A	108626920	A	A	108626920	3	1	276	1	0	0	0	0	1	0	0	0	14734	1174	41	2	1376	2	SLC5A7	2	108626920	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	12522	108626920	134572453	253	50142											
SULT1C2	6819	broad.mit.edu	37	chr2	108917299	108917299	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgagctattttaaaggtgtgGaaaaagccaaagcaatgccc	15	9	10	7	0	0	1	0	1	0	0	0	2	0	2	2	2	4	2	2	2	7	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:108917299G>A	uc002tdy.2	+	4	736	c.283G>A	c.(283-285)GAA>AAA	p.E95K	SULT1C2_uc010ywp.1_Intron|SULT1C2_uc002tdx.2_Intron|SULT1C2_uc010ywq.1_Missense_Mutation_p.E109K	NM_001056	NP_001047	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 1	95					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			ovary(1)	1						TAAAGGTGTGGAAAAAGCCAA	0.488													42	69					0	0	0	0	A	108917299	A	A	108917299	3	1	276	1	0	0	0	0	1	0	0	0	15443	1175	41	2	392	2	SULT1C2	2	108917299	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	290379	108917299	134282074	254	50143											
ACOXL	55289	broad.mit.edu	37	chr2	111851062	111851062	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgattacatcctttctgcAggagagatgctgaaacacaa	13	11	8	9	0	2	3	0	2	2	1	3	5	3	4	1	1	4	2	1	1	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:111851062A>C	uc002tgr.3	+	19	1857	c.1633_splice	c.e19-2	p.E545_splice	ACOXL_uc010fkc.2_Splice_Site_p.E515_splice|ACOXL_uc010yxk.1_Intron	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2						fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						TCCTTTCTGCAGGAGAGATGC	0.383													11	21					0	0	0	0	C	111851062	C	C	111851062	5	2	276	1	0	0	0	0	0	0	1	0	161	203	7	5		5	ACOXL	2	111851062	Splice_Site	SNP	A	TCGA-D6-6516-01A-11D-1870-08	2933763	111851062	131348311	255	50144											
MYO7B	4648	broad.mit.edu	37	chr2	128366402	128366402	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtggagaaggtgttcggcttCctccctgccatgattggggg	5	11	16	9	1	0	2	0	1	0	1	3	3	2	2	3	5	1	2	3	5	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:128366402C>T	uc002top.2	+	22	2816	c.2763C>T	c.(2761-2763)TTC>TTT	p.F921F		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	921						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGTTCGGCTTCCTCCCTGCCA	0.627													16	11					0	0	0	0	T	128366402	T	T	128366402	2	4	276	1	0	0	0	0	0	0	0	1	10136	854	30	2		2	MYO7B	2	128366402	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	16515340	128366402	114832971	256	50145											
FAM123C	205147	broad.mit.edu	37	chr2	131521446	131521446	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactgtccagggatgcctctCgagaggaagagacacgaggt	11	6	14	10	2	1	2	0	0	1	2	3	7	2	4	2	3	1	0	2	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:131521446C>T	uc002trw.2	+	2	1991	c.1801C>T	c.(1801-1803)CGA>TGA	p.R601*	FAM123C_uc010fmv.2_Nonsense_Mutation_p.R601*|FAM123C_uc010fms.1_Nonsense_Mutation_p.R601*|FAM123C_uc010fmt.1_Nonsense_Mutation_p.R601*|FAM123C_uc010fmu.1_Nonsense_Mutation_p.R601*	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	601										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GGATGCCTCTCGAGAGGAAGA	0.597													20	65					0	0	0	0	T	131521446	T	T	131521446	4	4	276	1	0	0	0	0	0	1	0	0	5452	876	31	1	1803	1	FAM123C	2	131521446	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3155044	131521446	111677927	257	50146											
ACMSD	130013	broad.mit.edu	37	chr2	135659396	135659396	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaagccggcaatgccctggCatttttgggtcttgagagaa	10	10	12	9	1	1	2	0	1	1	1	1	3	1	2	2	3	2	2	2	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:135659396C>A	uc002ttz.2	+	10	1044	c.977C>A	c.(976-978)GCA>GAA	p.A326E	ACMSD_uc002tua.2_Missense_Mutation_p.A268E|uc010zbe.1_Intron	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	326					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		AATGCCCTGGCATTTTTGGGT	0.294													17	51					6.33239e-15	6.53865e-15	1	0	A	135659396	A	A	135659396	3	1	276	1	0	0	0	0	1	0	0	0	144	710	25	4	1015	4	ACMSD	2	135659396	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4137950	135659396	107539977	258	50147											
R3HDM1	23518	broad.mit.edu	37	chr2	136396634	136396635	+	Silent	DNP	CC	TT	TT																															agcttcagtggaatctcagtCctgacaagaggtgatagttc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:136396634_136396635CC>TT	uc002tuo.2	+	14	1531_1532	c.1161_1162CC>TT	c.(1159-1164)GTCCTG>GTTTTG	p.387_388VL>VL	R3HDM1_uc010fni.2_Silent_p.385_386VL>VL|R3HDM1_uc002tup.2_Silent_p.331_332VL>VL|R3HDM1_uc010zbh.1_Silent_p.219_220VL>VL	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	387_388							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		GAATCTCAGTCCTGACAAGAGG	0.455													34	103					0	0	0	0	TT	136396635	TT	TT	136396634	2	4	276	1	0	0	0	0	0	0	0	1	12952	842	30	2		2	R3HDM1	2	136396634	Silent	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	737238	136396634	106802739	259	50148											
DARS	1615	broad.mit.edu	37	chr2	136681972	136681972	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catacctgaaataattttagGagtttggatttccacaaaac	15	13	6	7	0	0	1	0	1	0	0	1	3	1	3	2	2	2	1	2	2	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:136681972G>A	uc002tux.1	-	8	845	c.661C>T	c.(661-663)CCT>TCT	p.P221S	DARS_uc010fnj.1_Missense_Mutation_p.P121S	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	221					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	ATAATTTTAGGAGTTTGGATT	0.328													3	31					0	0	0	0	A	136681972	A	A	136681972	3	1	276	1	0	0	0	0	1	0	0	0	4258	1174	41	2	880	2	DARS	2	136681972	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	285338	136681972	106517401	260	50149											
THSD7B	80731	broad.mit.edu	37	chr2	137872796	137872796	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggacccgtgtgtggcggtggGatccagacccgggaggtgta	6	7	19	9	3	0	1	0	0	0	1	1	4	1	4	3	6	0	1	3	6	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:137872796G>A	uc002tva.1	+	4	1209	c.1209G>A	c.(1207-1209)GGG>GGA	p.G403G	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.G293G	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GTGGCGGTGGGATCCAGACCC	0.602													13	20					0	0	0	0	A	137872796	A	A	137872796	2	1	276	1	0	0	0	0	0	0	0	1	15946	1161	41	2		2	THSD7B	2	137872796	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1190824	137872796	105326577	261	50150											
LRP1B	53353	broad.mit.edu	37	chr2	141274580	141274580	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacatttgtgtttgttttgaActgtgataaaatatggaatg	12	17	9	3	0	0	2	0	2	0	0	0	3	0	3	0	1	1	2	0	1	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:141274580A>G	uc002tvj.1	-	50	8999	c.8027T>C	c.(8026-8028)GTT>GCT	p.V2676A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2676	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTGTTTTGAACTGTGATAAA	0.299										TSP Lung(27;0.18)			11	25					0	0	0	0	G	141274580	G	G	141274580	3	3	276	1	0	0	0	0	1	0	0	0	9005	57	2	5	5940	5	LRP1B	2	141274580	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	3401784	141274580	101924793	262	50151											
LRP1B	53353	broad.mit.edu	37	chr2	141294269	141294269	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgaataagcgttgcaggagGaatttttagctgcaagaaaa	15	9	11	6	2	0	1	0	0	0	1	0	4	0	3	1	2	4	4	1	2	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:141294269G>A	uc002tvj.1	-	46	8495	c.7523C>T	c.(7522-7524)TCC>TTC	p.S2508F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2508	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTTGCAGGAGGAATTTTTAGC	0.323										TSP Lung(27;0.18)			15	15					0	0	0	0	A	141294269	A	A	141294269	3	1	276	1	0	0	0	0	1	0	0	0	9005	1174	41	2	6460	2	LRP1B	2	141294269	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	19689	141294269	101905104	263	50152											
LRP1B	53353	broad.mit.edu	37	chr2	141751606	141751606	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcttccgtctaggcagtcatCgtcgccatcacatttccacc	7	11	7	16	3	3	0	2	0	1	0	7	0	5	0	4	1	0	2	4	1	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:141751606C>T	uc002tvj.1	-	16	3574	c.2602G>A	c.(2602-2604)GAT>AAT	p.D868N	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	868	Extracellular (Potential).|LDL-receptor class A 3.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGGCAGTCATCGTCGCCATCA	0.438										TSP Lung(27;0.18)			15	89					0	0	0	0	T	141751606	T	T	141751606	3	4	276	1	0	0	0	0	1	0	0	0	9005	884	31	1	11501	1	LRP1B	2	141751606	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	457337	141751606	101447767	264	50153											
LYPD6B	130576	broad.mit.edu	37	chr2	150071213	150071213	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgcctgggtctttgtgcttCcattgctgtgatgccaccat	4	16	10	11	0	1	1	0	1	1	0	2	1	2	1	4	1	4	2	4	1	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:150071213C>T	uc002twv.1	+	7	1014	c.613C>T	c.(613-615)CCA>TCA	p.P205S	LYPD6B_uc002tww.1_Missense_Mutation_p.P167S|LYPD6B_uc002twx.1_Missense_Mutation_p.P167S	NM_177964	NP_808879	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	181						anchored to membrane|plasma membrane					0						CTTTGTGCTTCCATTGCTGTG	0.507													39	134					0	0	0	0	T	150071213	T	T	150071213	3	4	276	1	0	0	0	0	1	0	0	0	9166	855	30	2	635	2	LYPD6B	2	150071213	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	8319607	150071213	93128160	265	50154											
RIF1	55183	broad.mit.edu	37	chr2	152320883	152320883	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagatgtaagcataaaatctCcgatttgcgaaaaacaagat	19	9	7	6	2	1	2	0	0	1	2	2	4	1	2	1	0	3	2	1	0	7	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:152320883C>T	uc002txm.2	+	30	4979	c.4849C>T	c.(4849-4851)CCG>TCG	p.P1617S	RIF1_uc002txl.2_Missense_Mutation_p.P1617S|RIF1_uc002txn.2_Missense_Mutation_p.P1617S|RIF1_uc002txo.2_Missense_Mutation_p.P1617S|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1617					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		CATAAAATCTCCGATTTGCGA	0.333													6	24					0	0	0	0	T	152320883	T	T	152320883	3	4	276	1	0	0	0	0	1	0	0	0	13424	855	30	2	4963	2	RIF1	2	152320883	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2249670	152320883	90878490	266	50155											
NEB	4703	broad.mit.edu	37	chr2	152534436	152534436	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tagacagctccaggtccatgGcgtcaggcaagtaggtgtaa	11	8	13	9	1	1	1	1	0	0	1	3	1	3	1	2	4	1	4	2	4	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:152534436G>A	uc010fnx.2	-	33	3712	c.3521C>T	c.(3520-3522)GCC>GTC	p.A1174V		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1174	Nebulin 29.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAGGTCCATGGCGTCAGGCAA	0.453													13	52					0	0	0	0	A	152534436	A	A	152534436	3	1	276	1	0	0	0	0	1	0	0	0	10356	1203	42	4	22765	4	NEB	2	152534436	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	213553	152534436	90664937	267	50156											
BAZ2B	29994	broad.mit.edu	37	chr2	160206292	160206292	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atccaagaggagctggggtaGgtgaaggtgacttagatggt	11	9	17	4	0	0	4	0	2	0	2	1	5	1	5	1	6	1	2	1	6	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:160206292G>A	uc002uao.2	-	28	5142	c.4790C>T	c.(4789-4791)CCT>CTT	p.P1597L	BAZ2B_uc002uap.2_Missense_Mutation_p.P1561L	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1597					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AGCTGGGGTAGGTGAAGGTGA	0.458													9	41					0	0	0	0	A	160206292	A	A	160206292	3	1	276	1	0	0	0	0	1	0	0	0	1334	1000	35	4	1756	4	BAZ2B	2	160206292	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7671856	160206292	82993081	268	50157											
FIGN	55137	broad.mit.edu	37	chr2	164466247	164466247	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagggggcccaccactgcttCctgacacaaatgagccacat	11	6	10	14	0	0	2	0	2	0	0	1	3	1	2	4	2	2	1	4	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:164466247C>T	uc002uck.1	-	3	2406	c.2095G>A	c.(2095-2097)GAA>AAA	p.E699K		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	699						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						ACCACTGCTTCCTGACACAAA	0.517													19	34					0	0	0	0	T	164466247	T	T	164466247	3	4	276	1	0	0	0	0	1	0	0	0	5923	864	30	2	188	2	FIGN	2	164466247	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4259955	164466247	78733126	269	50158											
SCN1A	6323	broad.mit.edu	37	chr2	166866245	166866245	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttaccctcatcccttcaaatCgagataaggctcttagaggt	11	12	7	11	1	3	2	2	0	1	2	5	3	4	2	2	2	1	1	2	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:166866245C>T	uc010zcz.1	-	20	3971	c.3953G>A	c.(3952-3954)CGA>CAA	p.R1318Q	SCN1A_uc002udo.3_Missense_Mutation_p.R1198Q|SCN1A_uc010fpk.2_Missense_Mutation_p.R1170Q	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1329	Helical; Voltage-sensor; Name=S4 of repeat III; (By similarity).|III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCCTTCAAATCGAGATAAGGC	0.363													31	32					0	0	0	0	T	166866245	T	T	166866245	3	4	276	1	0	0	0	0	1	0	0	0	13979	884	31	1	2071	1	SCN1A	2	166866245	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2399998	166866245	76333128	270	50159											
SCN7A	6332	broad.mit.edu	37	chr2	167298178	167298179	+	Missense_Mutation	DNP	CT	TC	TC																															gaacaacaacaggaccaagtCtttcagggccacccatgagt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:167298178_167298179CT>TC	uc002udu.1	-	14	2011_2012	c.1884_1885AG>GA	c.(1882-1887)AAAGAC>AAGAAC	p.D629N	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	629					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AGGACCAAGTCTTTCAGGGCCA	0.386													43	46					0	0	0	0	TC	167298179	TC	TC	167298178	3	4	276	1	0	0	0	0	1	0	0	0	13988	913	32	2	3211	2	SCN7A	2	167298178	Missense_Mutation	DNP	CT	TCGA-D6-6516-01A-11D-1870-08	431933	167298178	75901195	271	50160											
XIRP2	129446	broad.mit.edu	37	chr2	168105505	168105505	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	caggacaacaaaatccaaaaCcttatatgagaaaatttaag	21	8	5	7	0	0	1	0	1	0	1	1	3	1	2	2	1	2	0	2	1	10	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:168105505C>T	uc002udx.2	+	8	7621	c.7603C>T	c.(7603-7605)CCT>TCT	p.P2535S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.P2360S|XIRP2_uc010fpq.2_Missense_Mutation_p.P2313S|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2360					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAATCCAAAACCTTATATGAG	0.338													47	83					0	0	0	0	T	168105505	T	T	168105505	3	4	276	1	0	0	0	0	1	0	0	0	17498	507	18	4	7633	4	XIRP2	2	168105505	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	807327	168105505	75093868	272	50161											
ABCB11	8647	broad.mit.edu	37	chr2	169783744	169783744	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttccatgggaatttctttGgtgttgtctccatacttgat	6	19	8	8	0	2	1	0	1	2	0	4	2	3	2	2	2	1	1	2	2	2	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:169783744G>A	uc002ueo.1	-	26	3666	c.3540C>T	c.(3538-3540)ACC>ACT	p.T1180T	ABCB11_uc010zda.1_Silent_p.T598T|ABCB11_uc010zdb.1_Silent_p.T656T	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1180	Cytoplasmic (Potential).|ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GAATTTCTTTGGTGTTGTCTC	0.443													58	104					0	0	0	0	A	169783744	A	A	169783744	2	1	276	1	0	0	0	0	0	0	0	1	42	1335	47	4		4	ABCB11	2	169783744	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1678239	169783744	73415629	273	50162											
ABCB11	8647	broad.mit.edu	37	chr2	169824937	169824937	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccatggcttgagcttacCttaaactatcctggtagctc	8	12	8	13	0	0	1	0	1	0	0	2	1	1	1	4	2	4	4	4	2	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:169824937C>T	uc002ueo.1	-	17	2201	c.2075G>A	c.(2074-2076)AGG>AAG	p.R692K	ABCB11_uc010zda.1_Missense_Mutation_p.R134K|ABCB11_uc010zdb.1_Missense_Mutation_p.R168K	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	692	Cytoplasmic (Potential).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TTGAGCTTACCTTAAACTATC	0.423													6	16					0	0	0	0	T	169824937	T	T	169824937	3	4	276	1	0	0	0	0	1	0	0	0	42	695	24	4	1938	4	ABCB11	2	169824937	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	41193	169824937	73374436	274	50163											
LRP2	4036	broad.mit.edu	37	chr2	170038707	170038707	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtgaagggcaagtcctctgGgattatcaaagcagaaggtg	12	8	15	6	0	2	2	1	1	1	1	3	3	3	3	1	4	1	2	1	4	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:170038707G>A	uc002ues.2	-	51	10181	c.9968C>T	c.(9967-9969)CCC>CTC	p.P3323L		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3323	LDL-receptor class B 31.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AAGTCCTCTGGGATTATCAAA	0.537													34	64					0	0	0	0	A	170038707	A	A	170038707	3	1	276	1	0	0	0	0	1	0	0	0	9006	1232	43	4	4115	4	LRP2	2	170038707	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	213770	170038707	73160666	275	50164											
ATF2	1386	broad.mit.edu	37	chr2	175962174	175962174	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taaaaacaacacacataccgGagtttctgtagtggatgtgg	14	10	10	7	1	1	0	0	0	1	0	1	2	1	2	1	3	3	2	1	3	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:175962174G>A	uc002ujl.2	-	11	1238	c.976C>T	c.(976-978)CCG>TCG	p.P326S	ATF2_uc010fqv.2_Missense_Mutation_p.P277S|ATF2_uc002ujv.2_Missense_Mutation_p.P73S|ATF2_uc002ujm.2_Missense_Mutation_p.P268S|ATF2_uc002ujn.2_RNA|ATF2_uc002ujo.2_Intron|ATF2_uc002ujp.2_RNA|ATF2_uc002ujq.2_Missense_Mutation_p.P326S|ATF2_uc002ujr.2_RNA|ATF2_uc010fqu.2_Missense_Mutation_p.P308S|ATF2_uc002ujs.2_Missense_Mutation_p.P268S|ATF2_uc002ujt.2_RNA|ATF2_uc002uju.2_RNA|ATF2_uc002ujw.1_Missense_Mutation_p.P268S|ATF2_uc002ujx.1_RNA	NM_001880	NP_001871	P15336	ATF2_HUMAN	activating transcription factor 2	326					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(1)|breast(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.125)			ACACATACCGGAGTTTCTGTA	0.403													17	84					0	0	0	0	A	175962174	A	A	175962174	3	1	276	1	0	0	0	0	1	0	0	0	1082	1174	41	2	557	2	ATF2	2	175962174	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5923467	175962174	67237199	276	50165											
HOXD3	3232	broad.mit.edu	37	chr2	177033899	177033899	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgagtgcacaatgcagaaGgctgcttactatgaaaaccc	13	8	9	11	0	0	3	0	2	0	1	0	3	0	3	2	1	5	4	2	1	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:177033899G>A	uc002ukt.1	+	2	233	c.57G>A	c.(55-57)AAG>AAA	p.K19K		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	19					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		CAATGCAGAAGGCTGCTTACT	0.537													17	66					0	0	0	0	A	177033899	A	A	177033899	2	1	276	1	0	0	0	0	0	0	0	1	7362	991	35	4		4	HOXD3	2	177033899	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1071725	177033899	66165474	277	50166											
TTC30A	92104	broad.mit.edu	37	chr2	178482974	178482974	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgacctggccatcggtctcAttgtcgcctccactttcttc	4	15	7	15	2	2	1	1	1	2	0	7	1	3	1	4	2	0	0	4	2	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:178482974A>C	uc002ulo.2	-	1	721	c.456T>G	c.(454-456)AAT>AAG	p.N152K		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	152					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			CATCGGTCTCATTGTCGCCTC	0.577													31	115					0	0	0	0	C	178482974	C	C	178482974	3	2	276	1	0	0	0	0	1	0	0	0	16766	214	8	5	1545	5	TTC30A	2	178482974	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1449075	178482974	64716399	278	50167											
TTN	7273	broad.mit.edu	37	chr2	179439624	179439624	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaggtgggtcccaagagaaGgttacaaaatcagatgaaac	16	7	11	7	0	2	3	2	1	0	2	3	4	3	3	1	3	2	1	1	3	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179439624G>A	uc010zfg.1	-	275	63755	c.63531C>T	c.(63529-63531)ACC>ACT	p.T21177T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T14872T|TTN_uc010zfi.1_Silent_p.T14805T|TTN_uc010zfj.1_Silent_p.T14680T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22104							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCAAGAGAAGGTTACAAAAT	0.453													14	18					0	0	0	0	A	179439624	A	A	179439624	2	1	276	1	0	0	0	0	0	0	0	1	16803	987	35	4		4	TTN	2	179439624	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	956650	179439624	63759749	279	50168											
TTN	7273	broad.mit.edu	37	chr2	179446509	179446509	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gttgtatcatatactttaggGaaagccggtgggccaggagg	10	10	15	6	1	1	0	1	0	0	0	1	2	1	2	2	5	2	2	2	5	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179446509G>A	uc010zfg.1	-	265	59006	c.58782C>T	c.(58780-58782)TTC>TTT	p.F19594F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.F13289F|TTN_uc010zfi.1_Silent_p.F13222F|TTN_uc010zfj.1_Silent_p.F13097F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20521							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACTTTAGGGAAAGCCGGTG	0.438													4	18					0	0	0	0	A	179446509	A	A	179446509	2	1	276	1	0	0	0	0	0	0	0	1	16803	1165	41	2		2	TTN	2	179446509	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6885	179446509	63752864	280	50169											
TTN	7273	broad.mit.edu	37	chr2	179474103	179474103	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaggcaggacaaatggttCttcttcttgaacttcaccct	10	12	8	11	0	4	2	1	1	3	1	4	3	4	3	1	3	1	2	1	3	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179474103C>T	uc010zfg.1	-	222	44454	c.44230G>A	c.(44230-44232)GAA>AAA	p.E14744K	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E8439K|TTN_uc010zfi.1_Missense_Mutation_p.E8372K|TTN_uc010zfj.1_Missense_Mutation_p.E8247K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15671							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAAATGGTTCTTCTTCTTGA	0.448													4	52					0	0	0	0	T	179474103	T	T	179474103	3	4	276	1	0	0	0	0	1	0	0	0	16803	922	32	2	56119	2	TTN	2	179474103	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	27594	179474103	63725270	281	50170											
TTN	7273	broad.mit.edu	37	chr2	179486278	179486278	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagcatcctcaaggtgagcGttctgaatgaccaggattct	10	10	10	11	1	3	3	1	3	2	0	4	4	4	4	3	2	2	2	3	2	2	2	rs72677223		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179486278G>A	uc010zfg.1	-	194	37793	c.37569C>T	c.(37567-37569)AAC>AAT	p.N12523N	TTN_uc010zfh.1_Silent_p.N6218N|TTN_uc010zfi.1_Silent_p.N6151N|TTN_uc010zfj.1_Silent_p.N6026N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13450							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGGTGAGCGTTCTGAATGA	0.443													9	67					0	0	0	0	A	179486278	A	A	179486278	2	1	276	1	0	0	0	0	0	0	0	1	16803	1136	40	1		1	TTN	2	179486278	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	12175	179486278	63713095	282	50171											
TTN	7273	broad.mit.edu	37	chr2	179542597	179542597	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcaaatagaacttcctcttCctgaggtagagctacaggaa	13	11	8	9	0	2	3	1	1	1	2	4	4	4	4	2	2	3	2	2	2	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179542597C>T	uc010zfg.1	-	143	30534	c.30310G>A	c.(30310-30312)GAA>AAA	p.E10104K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E6765K|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11031							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTCCTCTTCCTGAGGTAGA	0.383													22	82					0	0	0	0	T	179542597	T	T	179542597	3	4	276	1	0	0	0	0	1	0	0	0	16803	864	30	2	70355	2	TTN	2	179542597	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	56319	179542597	63656776	283	50172											
TTN	7273	broad.mit.edu	37	chr2	179590733	179590733	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgacttcagcatttttaagGgtttctactataggagggaa	11	14	10	6	0	2	1	1	1	1	0	2	3	2	3	0	3	2	2	0	3	5	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179590733G>A	uc010zfg.1	-	67	16808	c.16584C>T	c.(16582-16584)ACC>ACT	p.T5528T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T2189T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6455							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTTTTAAGGGTTTCTACTA	0.403													9	55					0	0	0	0	A	179590733	A	A	179590733	2	1	276	1	0	0	0	0	0	0	0	1	16803	1219	43	4		4	TTN	2	179590733	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	48136	179590733	63608640	284	50173											
TTN	7273	broad.mit.edu	37	chr2	179594214	179594214	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcaaacggaggtgttccCgtaacttcacactccagctc	10	10	7	14	2	2	0	2	0	0	0	5	1	4	1	2	2	3	3	2	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179594214C>T	uc010zfg.1	-	61	15161	c.14937G>A	c.(14935-14937)ACG>ACA	p.T4979T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T1640T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5906							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGGTGTTCCCGTAACTTCAC	0.448													16	101					0	0	0	0	T	179594214	T	T	179594214	2	4	276	1	0	0	0	0	0	0	0	1	16803	639	23	1		1	TTN	2	179594214	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3481	179594214	63605159	285	50174											
TTN	7273	broad.mit.edu	37	chr2	179605333	179605333	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgtggataattcccttcAggttcagctaataaagtttt	11	15	8	7	0	2	0	2	0	0	0	3	2	3	1	1	2	1	3	1	2	4	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179605333A>T	uc010zfh.1	-	46	12338	c.12114T>A	c.(12112-12114)CCT>CCA	p.P4038P	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Silent_p.P3971P|TTN_uc010zfj.1_Silent_p.P3846P|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	3961							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTCCCTTCAGGTTCAGCTA	0.383													17	92					0	0	0	0	T	179605333	T	T	179605333	2	4	276	1	0	0	0	0	0	0	0	1	16803	175	7	5		5	TTN	2	179605333	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	11119	179605333	63594040	286	50175											
TTN	7273	broad.mit.edu	37	chr2	179616729	179616729	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaaaaggcgtcacgtgtatcCctttctgaatgttcagattc	10	13	9	9	2	3	2	2	1	1	1	5	3	4	2	1	1	0	2	1	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179616729C>T	uc002unb.2	-	46	10622	c.10398G>A	c.(10396-10398)AGG>AGA	p.R3466R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACGTGTATCCCTTTCTGAAT	0.358													68	138					0	0	0	0	T	179616729	T	T	179616729	2	4	276	1	0	0	0	0	0	0	0	1	16803	622	22	4		4	TTN	2	179616729	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	11396	179616729	63582644	287	50176											
CCDC141	285025	broad.mit.edu	37	chr2	179732821	179732821	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgtggagatggtctacacGggcttgcttttcctgagagc	6	13	13	9	1	2	2	0	1	2	2	3	4	3	2	1	3	3	2	1	3	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179732821G>A	uc002unf.1	-	6	838	c.781C>T	c.(781-783)CGT>TGT	p.R261C		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	261							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TGGTCTACACGGGCTTGCTTT	0.498													43	41					0	0	0	0	A	179732821	A	A	179732821	3	1	276	1	0	0	0	0	1	0	0	0	2787	1116	39	1	1878	1	CCDC141	2	179732821	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	116092	179732821	63466552	288	50177											
CCDC141	285025	broad.mit.edu	37	chr2	179742774	179742774	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tagctgccactgcttctcagCcgagtcagaacaatgcttgg	9	10	10	12	1	2	1	2	0	1	1	3	2	2	1	2	1	6	3	2	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:179742774C>T	uc002unf.1	-	2	148	c.91G>A	c.(91-93)GCT>ACT	p.A31T	CCDC141_uc002ung.2_Missense_Mutation_p.A606T	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	31							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TGCTTCTCAGCCGAGTCAGAA	0.368													21	79					0	0	0	0	T	179742774	T	T	179742774	3	4	276	1	0	0	0	0	1	0	0	0	2787	739	26	4	2584	4	CCDC141	2	179742774	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	9953	179742774	63456599	289	50178											
NEUROD1	4760	broad.mit.edu	37	chr2	182543494	182543494	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgtctgcctcgtgctcctCgtcctgagaactgagacact	6	12	9	14	2	1	2	0	2	1	2	5	4	3	2	3	0	3	1	3	0	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:182543494C>T	uc002uof.2	-	2	330	c.94G>A	c.(94-96)GAG>AAG	p.E32K	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	32					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TCGTGCTCCTCGTCCTGAGAA	0.512													9	20					0	0	0	0	T	182543494	T	T	182543494	3	4	276	1	0	0	0	0	1	0	0	0	10402	893	31	1	980	1	NEUROD1	2	182543494	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2800720	182543494	60655879	290	50179											
NCKAP1	10787	broad.mit.edu	37	chr2	183843628	183843628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gatgattgattcatcttcagGgcaaacagaaagattctgaa	15	11	9	6	0	4	5	2	3	2	2	4	6	4	5	0	1	1	1	0	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:183843628G>A	uc002upc.2	-	14	1759	c.1357C>T	c.(1357-1359)CCT>TCT	p.P453S	NCKAP1_uc002upb.2_Missense_Mutation_p.P459S	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	453					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TCATCTTCAGGGCAAACAGAA	0.199													8	48					0	0	0	0	A	183843628	A	A	183843628	3	1	276	1	0	0	0	0	1	0	0	0	10275	1232	43	4	2101	4	NCKAP1	2	183843628	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1300134	183843628	59355745	291	50180											
ZNF804A	91752	broad.mit.edu	37	chr2	185802719	185802719	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacaagaagttgcaaaaatcGaaaggaactcagaacaaaca	22	4	7	8	1	1	2	1	0	0	2	2	4	1	3	0	1	4	2	0	1	8	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:185802719G>A	uc002uph.2	+	4	3190	c.2596G>A	c.(2596-2598)GAA>AAA	p.E866K		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	866						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TGCAAAAATCGAAAGGAACTC	0.353													19	41					0	0	0	0	A	185802719	A	A	185802719	3	1	276	1	0	0	0	0	1	0	0	0	18237	1059	37	1	2610	1	ZNF804A	2	185802719	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1959091	185802719	57396654	292	50181											
SLC40A1	30061	broad.mit.edu	37	chr2	190426734	190426734	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtggcccattgccacaaagGagactgaaatcaatacgagc	14	7	10	10	1	1	2	1	1	0	1	1	4	1	2	2	2	3	0	2	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:190426734G>A	uc002uqp.3	-	8	1937	c.1586C>T	c.(1585-1587)TCC>TTC	p.S529F		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	529	Helical; (Potential).				anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			TGCCACAAAGGAGACTGAAAT	0.433													5	36					0	0	0	0	A	190426734	A	A	190426734	3	1	276	1	0	0	0	0	1	0	0	0	14692	1174	41	2	133	2	SLC40A1	2	190426734	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4624015	190426734	52772639	293	50182											
PGAP1	80055	broad.mit.edu	37	chr2	197729786	197729786	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gacataagcaggaagagctcCaccatgaaatctaactacct	16	7	7	11	0	1	2	0	1	1	1	2	4	2	3	3	1	4	2	3	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:197729786C>A	uc002utw.2	-	20	1900	c.1786G>T	c.(1786-1788)GGA>TGA	p.G596*	PGAP1_uc002utx.2_Nonsense_Mutation_p.G422*|PGAP1_uc002uty.1_Intron	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	596	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						GGAAGAGCTCCACCATGAAAT	0.328													20	29					1.01871e-10	1.04424e-10	1	0	A	197729786	A	A	197729786	4	1	276	1	0	0	0	0	0	1	0	0	11832	603	21	4	1014	4	PGAP1	2	197729786	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	7303052	197729786	45469587	294	50183											
ANKRD44	91526	broad.mit.edu	37	chr2	197990587	197990587	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggccgttcagagccgcatGgtgcaaggctgtgcgccccc	5	7	15	14	3	1	1	1	0	0	1	1	1	1	1	4	3	3	4	4	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:197990587G>A	uc002uuc.2	-	5	603	c.436C>T	c.(436-438)CAT>TAT	p.H146Y	ANKRD44_uc002uua.1_Missense_Mutation_p.H121Y|ANKRD44_uc002uub.2_Missense_Mutation_p.H146Y|ANKRD44_uc010zgw.1_Missense_Mutation_p.H74Y	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	146	ANK 5.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AGAGCCGCATGGTGCAAGGCT	0.537													15	88					0	0	0	0	A	197990587	A	A	197990587	3	1	276	1	0	0	0	0	1	0	0	0	672	1348	47	4	2486	4	ANKRD44	2	197990587	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	260801	197990587	45208786	295	50184											
SATB2	23314	broad.mit.edu	37	chr2	200173603	200173603	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggttcaggaagcgacggatGgtacagaggttttcccagag	11	8	15	7	2	1	2	1	0	0	2	2	5	2	4	1	5	2	3	1	5	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:200173603G>A	uc002uuy.1	-	10	2437	c.1620C>T	c.(1618-1620)ACC>ACT	p.T540T	SATB2_uc010fsq.1_Silent_p.T422T|SATB2_uc002uuz.1_Silent_p.T540T|SATB2_uc002uva.1_Silent_p.T540T	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	540	CUT 2.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGCGACGGATGGTACAGAGGT	0.572													16	63					0	0	0	0	A	200173603	A	A	200173603	2	1	276	1	0	0	0	0	0	0	0	1	13919	1335	47	4		4	SATB2	2	200173603	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2183016	200173603	43025770	296	50185											
WDR12	55759	broad.mit.edu	37	chr2	203776182	203776182	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttatcagtgtagaagcgTgtttggagctgagccatggc	8	13	14	6	1	1	2	1	1	0	1	1	3	1	3	1	2	3	4	1	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:203776182T>A	uc002uzl.2	-	1	768	c.18A>T	c.(16-18)ACA>ACT	p.T6T	ALS2CR8_uc002uzn.2_5'Flank|ALS2CR8_uc002uzm.2_5'Flank|ALS2CR8_uc010zhy.1_5'Flank|ALS2CR8_uc010zhz.1_5'Flank|ALS2CR8_uc010ftu.1_5'Flank|ALS2CR8_uc002uzo.2_5'Flank|ALS2CR8_uc010zia.1_5'Flank|ALS2CR8_uc010zib.1_5'Flank|ALS2CR8_uc010zic.1_5'Flank|ALS2CR8_uc002uzp.2_5'Flank|WDR12_uc010ftt.2_Silent_p.T6T	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	6					cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						TGTAGAAGCGTGTTTGGAGCT	0.522													16	56					0	0	0	0	A	203776182	A	A	203776182	2	1	276	1	0	0	0	0	0	0	0	1	17342	1683	59	5		5	WDR12	2	203776182	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	3602579	203776182	39423191	297	50186											
NBEAL1	65065	broad.mit.edu	37	chr2	204055018	204055018	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	acttcttctggttttaggagCtgtggatctggatgccttaa	7	16	11	7	0	3	0	0	0	3	0	3	3	3	3	1	4	2	2	1	4	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:204055018C>T	uc002uzt.3	+	45	7073	c.6740C>T	c.(6739-6741)GCT>GTT	p.A2247V	NBEAL1_uc002uzs.3_Missense_Mutation_p.A957V	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2247	BEACH.						binding			ovary(1)|skin(1)	2						GTTTTAGGAGCTGTGGATCTG	0.343													37	75					0	0	0	0	T	204055018	T	T	204055018	3	4	276	1	0	0	0	0	1	0	0	0	10241	797	28	4	6914	4	NBEAL1	2	204055018	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	278836	204055018	39144355	298	50187											
PARD3B	117583	broad.mit.edu	37	chr2	206480250	206480250	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctacaaggaaagggagcttCcctattatccaggggctcat	11	10	10	10	0	2	0	1	0	1	0	4	2	4	2	2	4	2	2	2	4	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:206480250C>T	uc002var.1	+	23	3538	c.3331C>T	c.(3331-3333)CCC>TCC	p.P1111S	PARD3B_uc002vao.1_Missense_Mutation_p.P1010S|PARD3B_uc002vap.1_Missense_Mutation_p.P1049S|PARD3B_uc002vaq.1_Missense_Mutation_p.P1042S|uc010fuc.1_5'Flank	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	1111					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		AAGGGAGCTTCCCTATTATCC	0.577													12	74					0	0	0	0	T	206480250	T	T	206480250	3	4	276	1	0	0	0	0	1	0	0	0	11498	855	30	2	3421	2	PARD3B	2	206480250	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2425232	206480250	36719123	299	50188											
FAM119A	151194	broad.mit.edu	37	chr2	208486555	208486555	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcagccactatgcccacCagccccgtgccagcacccag	9	3	10	19	1	0	0	0	0	0	0	0	0	0	0	7	1	5	2	7	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:208486555C>T	uc002vcf.2	-	3	394	c.234G>A	c.(232-234)CTG>CTA	p.L78L	FAM119A_uc002vce.2_Silent_p.L78L|FAM119A_uc010fuk.1_Silent_p.L78L|FAM119A_uc002vcg.3_Silent_p.L78L	NM_145280	NP_660323	Q8WXB1	MT21A_HUMAN	hypothetical protein LOC151194	78	Helical; (Potential).					integral to membrane	methyltransferase activity				0				LUSC - Lung squamous cell carcinoma(261;0.0705)|Epithelial(149;0.131)|Lung(261;0.135)		CTATGCCCACCAGCCCCGTGC	0.557													9	67					0	0	0	0	T	208486555	T	T	208486555	2	4	276	1	0	0	0	0	0	0	0	1	5441	581	21	4		4	FAM119A	2	208486555	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2006305	208486555	34712818	300	50189											
MAP2	4133	broad.mit.edu	37	chr2	210559487	210559487	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaaacggacagtcagctcGaagacctgggctactgtgtg	12	8	12	9	2	1	1	1	0	0	1	2	3	1	2	1	2	3	2	1	2	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:210559487G>T	uc002vde.1	+	7	2841	c.2593G>T	c.(2593-2595)GAA>TAA	p.E865*	MAP2_uc002vdc.1_Nonsense_Mutation_p.E865*|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Nonsense_Mutation_p.E861*	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	865					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CAGTCAGCTCGAAGACCTGGG	0.468													31	46					1.55811e-20	1.61742e-20	1	0	T	210559487	T	T	210559487	4	4	276	1	0	0	0	0	0	1	0	0	9288	1059	37	3	2607	3	MAP2	2	210559487	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2072932	210559487	32639886	301	50190											
CPS1	1373	broad.mit.edu	37	chr2	211503916	211503916	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acccatcagtaacaaactatCtctatgttacctacaatggt	14	12	4	11	0	2	0	1	0	1	0	3	0	2	0	2	1	4	2	2	1	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:211503916C>G	uc002vee.3	+	23	3004	c.2872C>G	c.(2872-2874)CTC>GTC	p.L958V	CPS1_uc010fur.2_Missense_Mutation_p.L964V|CPS1_uc010fus.2_Missense_Mutation_p.L507V	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	958					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AACAAACTATCTCTATGTTAC	0.313													3	25					0	0	0	0	G	211503916	G	G	211503916	3	3	276	1	0	0	0	0	1	0	0	0	3838	913	32	2	2984	2	CPS1	2	211503916	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	944429	211503916	31695457	302	50191											
BARD1	580	broad.mit.edu	37	chr2	215610516	215610516	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcactgagcattttctgttgTtctgaagacagcccactgcc	8	13	8	12	0	3	3	1	2	2	1	3	3	3	3	2	0	3	3	2	0	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:215610516T>C	uc002veu.2	-	8	1875	c.1740A>G	c.(1738-1740)GAA>GAG	p.E580E	BARD1_uc010zjm.1_Silent_p.E436E	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	580	BRCT 1.				cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTTTCTGTTGTTCTGAAGACA	0.403									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				39	170					0	0	0	0	C	215610516	C	C	215610516	2	2	276	1	0	0	0	0	0	0	0	1	1314	1722	60	5		5	BARD1	2	215610516	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	4106600	215610516	27588857	303	50192											
FN1	2335	broad.mit.edu	37	chr2	216269261	216269261	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actgcctgggctgtcctcttCgggtaaggcccacggtcagt	5	10	13	13	2	2	0	1	0	1	0	4	0	3	0	3	4	1	2	3	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:216269261C>T	uc002vfa.2	-	20	3370	c.3104G>A	c.(3103-3105)CGA>CAA	p.R1035Q	FN1_uc002vfb.2_Missense_Mutation_p.R1035Q|FN1_uc002vfc.2_Missense_Mutation_p.R1035Q|FN1_uc002vfd.2_Missense_Mutation_p.R1035Q|FN1_uc002vfe.2_Missense_Mutation_p.R1035Q|FN1_uc002vff.2_Missense_Mutation_p.R1035Q|FN1_uc002vfg.2_Missense_Mutation_p.R1035Q|FN1_uc002vfh.2_Missense_Mutation_p.R1035Q|FN1_uc002vfi.2_Missense_Mutation_p.R1035Q|FN1_uc002vfj.2_Missense_Mutation_p.R1035Q	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1035	|Fibronectin type-III 5.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGTCCTCTTCGGGTAAGGCC	0.552													18	50					0	0	0	0	T	216269261	T	T	216269261	3	4	276	1	0	0	0	0	1	0	0	0	5994	884	31	1	4437	1	FN1	2	216269261	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	658745	216269261	26930112	304	50193											
IGFBP5	3488	broad.mit.edu	37	chr2	217542855	217542855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctttctcttgtagaatcCtttgcggtcacaattgggca	7	15	9	10	1	2	1	1	0	1	1	4	1	3	1	1	2	2	3	1	2	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:217542855C>T	uc002vgj.3	-	3	1441	c.667G>A	c.(667-669)GGA>AGA	p.G223R		NM_000599	NP_000590	P24593	IBP5_HUMAN	insulin-like growth factor binding protein 5	223	Thyroglobulin type-1.				negative regulation of insulin-like growth factor receptor signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of translation|signal transduction		insulin-like growth factor I binding				0		Renal(323;0.0822)		Epithelial(149;2.1e-06)|all cancers(144;0.000165)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGTAGAATCCTTTGCGGTCA	0.602													10	63					0	0	0	0	T	217542855	T	T	217542855	3	4	276	1	0	0	0	0	1	0	0	0	7621	690	24	4	159	4	IGFBP5	2	217542855	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1273594	217542855	25656518	305	50194											
TNS1	7145	broad.mit.edu	37	chr2	218712421	218712421	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggcaggcaaggaggaagagGctgggctctttgaatggaaa	13	6	17	5	0	1	2	0	1	1	1	1	5	1	5	0	7	0	4	0	7	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:218712421G>A	uc002vgt.2	-	17	2842	c.2444C>T	c.(2443-2445)GCC>GTC	p.A815V	TNS1_uc002vgr.2_Missense_Mutation_p.A815V|TNS1_uc002vgs.2_Missense_Mutation_p.A815V|TNS1_uc010zjv.1_Missense_Mutation_p.A815V|TNS1_uc010fvj.1_Missense_Mutation_p.A883V|TNS1_uc010fvk.1_Missense_Mutation_p.A940V|TNS1_uc010fvi.1_Missense_Mutation_p.A502V	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	815						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGAGGAAGAGGCTGGGCTCTT	0.597													29	36					0	0	0	0	A	218712421	A	A	218712421	3	1	276	1	0	0	0	0	1	0	0	0	16409	1203	42	4	2831	4	TNS1	2	218712421	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1169566	218712421	24486952	306	50195											
PNKD	25953	broad.mit.edu	37	chr2	219208288	219208288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acactgtgctggggctagggGatgacacccttctgtggcct	6	10	14	11	0	1	1	0	1	1	0	1	2	1	2	2	5	1	2	2	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:219208288G>A	uc002vhn.2	+	8	991	c.847G>A	c.(847-849)GAT>AAT	p.D283N	PNKD_uc002vhq.2_Missense_Mutation_p.D259N	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	283						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGCTAGGGGATGACACCCT	0.632													6	13					0	0	0	0	A	219208288	A	A	219208288	3	1	276	1	0	0	0	0	1	0	0	0	12201	1174	41	2	1242	2	PNKD	2	219208288	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	495867	219208288	23991085	307	50196											
VIL1	7429	broad.mit.edu	37	chr2	219292994	219292994	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaccgaggggatgttttcctCctggaccttgggaagcttat	8	12	12	9	1	0	0	0	0	0	0	2	4	2	3	4	4	2	2	4	4	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:219292994C>T	uc002via.2	+	6	566	c.501C>T	c.(499-501)CTC>CTT	p.L167L	VIL1_uc010zke.1_Intron|VIL1_uc002vib.2_Silent_p.L167L|VIL1_uc002vic.1_Silent_p.L167L	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	167	Gelsolin-like 2.|Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATGTTTTCCTCCTGGACCTTG	0.552													11	56					0	0	0	0	T	219292994	T	T	219292994	2	4	276	1	0	0	0	0	0	0	0	1	17232	842	30	2		2	VIL1	2	219292994	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	84706	219292994	23906379	308	50197											
ZNF142	7701	broad.mit.edu	37	chr2	219508571	219508571	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttctttctgagtagaacagGgcacttcttcagcaggtggg	8	12	13	8	0	4	2	1	1	3	1	4	2	4	2	0	3	2	4	0	3	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:219508571G>A	uc002vin.2	-	8	3104	c.2668C>T	c.(2668-2670)CCT>TCT	p.P890S	ZNF142_uc002vil.2_Missense_Mutation_p.P851S|ZNF142_uc010fvt.2_Missense_Mutation_p.P727S|ZNF142_uc002vim.2_Missense_Mutation_p.P727S	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	890					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGTAGAACAGGGCACTTCTTC	0.607													21	124					0	0	0	0	A	219508571	A	A	219508571	3	1	276	1	0	0	0	0	1	0	0	0	17798	1232	43	4	2407	4	ZNF142	2	219508571	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	215577	219508571	23690802	309	50198											
RNF25	64320	broad.mit.edu	37	chr2	219536676	219536676	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctcccctgcagctgcAgacgcagacgccgccatatc	7	7	8	19	3	0	2	0	0	0	2	4	2	3	2	6	0	3	4	6	0	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:219536676A>G	uc002vit.2	-	1	106	c.18T>C	c.(16-18)TCT>TCC	p.S6S	STK36_uc002viu.2_5'Flank|STK36_uc002viv.2_5'Flank|RNF25_uc010fvw.2_5'UTR	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	6					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGCAGCTGCAGACGCAGACG	0.622													6	15					0	0	0	0	G	219536676	G	G	219536676	2	3	276	1	0	0	0	0	0	0	0	1	13550	175	7	5		5	RNF25	2	219536676	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	28105	219536676	23662697	310	50199											
CCDC108	255101	broad.mit.edu	37	chr2	219892419	219892419	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caccgtgtaaaggcagttggGgtgaggcggctggaagtgca	9	7	18	7	2	0	1	0	1	0	0	0	2	0	2	1	6	1	5	1	6	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:219892419G>A	uc002vjl.1	-	13	2248	c.2164C>T	c.(2164-2166)CCC>TCC	p.P722S	CCDC108_uc010fwa.1_Missense_Mutation_p.P165S|CCDC108_uc010zkp.1_Missense_Mutation_p.P711S|CCDC108_uc010zkq.1_Missense_Mutation_p.P657S	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	722						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGCAGTTGGGGTGAGGCGGC	0.612													14	83					0	0	0	0	A	219892419	A	A	219892419	3	1	276	1	0	0	0	0	1	0	0	0	2755	1232	43	4	3705	4	CCDC108	2	219892419	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	355743	219892419	23306954	311	50200											
FAM134A	79137	broad.mit.edu	37	chr2	220047121	220047121	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccctccccttccattctcCcacctgttccccaggactca	5	10	3	23	0	2	0	1	0	1	0	6	1	5	1	9	1	0	1	9	1	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:220047121C>T	uc002vjw.3	+	9	1538	c.1402C>T	c.(1402-1404)CCA>TCA	p.P468S	FAM134A_uc010fwc.2_Missense_Mutation_p.P261S|FAM134A_uc002vjx.2_Intron	NM_024293	NP_077269	Q8NC44	F134A_HUMAN	hypothetical protein LOC79137	468						endoplasmic reticulum|integral to membrane				ovary(1)|central_nervous_system(1)	2		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTCCATTCTCCCACCTGTTCC	0.627													27	59					0	0	0	0	T	220047121	T	T	220047121	3	4	276	1	0	0	0	0	1	0	0	0	5473	623	22	4	1436	4	FAM134A	2	220047121	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	154702	220047121	23152252	312	50201											
SPEG	10290	broad.mit.edu	37	chr2	220356873	220356873	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctatgagccagacccccagGaaacggaggctcggattgtg	10	7	13	11	2	1	2	0	1	1	1	2	5	1	5	3	4	2	1	3	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:220356873G>A	uc010fwg.2	+	40	9502	c.9502G>A	c.(9502-9504)GAA>AAA	p.E3168K		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	3168	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGACCCCCAGGAAACGGAGGC	0.582													13	32					0	0	0	0	A	220356873	A	A	220356873	3	1	276	1	0	0	0	0	1	0	0	0	15102	1175	41	2	9672	2	SPEG	2	220356873	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	309752	220356873	22842500	313	50202											
OBSL1	23363	broad.mit.edu	37	chr2	220422771	220422771	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagctcagcaccactggctcCccaggggccacacagagcgg	9	3	12	17	1	1	1	1	0	0	1	2	1	2	1	4	4	3	3	4	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:220422771C>T	uc010fwk.2	-	11	3621	c.3564G>A	c.(3562-3564)GGG>GGA	p.G1188G	OBSL1_uc002vmh.1_Silent_p.G179G|OBSL1_uc010zli.1_Silent_p.G87G|OBSL1_uc010fwl.1_Silent_p.G663G	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1188	Ig-like 10.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CCACTGGCTCCCCAGGGGCCA	0.642													5	26					0	0	0	0	T	220422771	T	T	220422771	2	4	276	1	0	0	0	0	0	0	0	1	10867	610	22	4		4	OBSL1	2	220422771	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	65898	220422771	22776602	314	50203											
EPHA4	2043	broad.mit.edu	37	chr2	222301166	222301166	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcctcaagcactcgggacaTgccaaaatcagacactttgc	13	8	7	13	1	2	1	2	0	0	1	4	2	3	2	2	1	3	1	2	1	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:222301166T>C	uc002vmq.2	-	13	2341	c.2299A>G	c.(2299-2301)ATG>GTG	p.M767V	EPHA4_uc002vmr.2_Missense_Mutation_p.M767V|EPHA4_uc010zlm.1_Missense_Mutation_p.M708V|EPHA4_uc010zln.1_Missense_Mutation_p.M767V	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	767	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		ACTCGGGACATGCCAAAATCA	0.488													20	23					0	0	0	0	C	222301166	C	C	222301166	3	2	276	1	0	0	0	0	1	0	0	0	5193	1464	51	5	681	5	EPHA4	2	222301166	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1878395	222301166	20898207	315	50204											
EPHA4	2043	broad.mit.edu	37	chr2	222308288	222308288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctctcgcactgcttggttggGatcttcgtacgtaaaggggt	6	13	13	9	3	2	0	0	0	2	0	4	1	2	1	0	4	2	5	0	4	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:222308288G>A	uc002vmq.2	-	10	1855	c.1813C>T	c.(1813-1815)CCC>TCC	p.P605S	EPHA4_uc002vmr.2_Missense_Mutation_p.P605S|EPHA4_uc010zlm.1_Missense_Mutation_p.P546S|EPHA4_uc010zln.1_Missense_Mutation_p.P605S	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	605	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GCTTGGTTGGGATCTTCGTAC	0.398													26	43					0	0	0	0	A	222308288	A	A	222308288	3	1	276	1	0	0	0	0	1	0	0	0	5193	1174	41	2	1179	2	EPHA4	2	222308288	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7122	222308288	20891085	316	50205											
WDFY1	57590	broad.mit.edu	37	chr2	224760271	224760271	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccttcctccgatgtcccaCatgatgatgctgttgtcaga	7	14	8	12	1	1	3	1	2	0	1	5	4	5	3	4	0	1	2	4	0	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:224760271C>A	uc002vnq.2	-	7	726	c.675G>T	c.(673-675)ATG>ATT	p.M225I		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	225	WD 5.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		CGATGTCCCACATGATGATGC	0.552													11	61					6.42651e-13	6.60626e-13	1	0	A	224760271	A	A	224760271	3	1	276	1	0	0	0	0	1	0	0	0	17336	478	17	4	581	4	WDFY1	2	224760271	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2451983	224760271	18439102	317	50206											
COL4A4	1286	broad.mit.edu	37	chr2	227985823	227985823	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atgggtcctggggctcccagGggtccaattggaccctgtgg	5	9	16	11	0	0	0	0	0	0	0	3	1	3	1	4	7	0	1	4	7	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:227985823G>A	uc010zlt.1	-	5	888	c.234C>T	c.(232-234)CCC>CCT	p.P78P		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	78	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GGGCTCCCAGGGGTCCAATTG	0.547													6	32					0	0	0	0	A	227985823	A	A	227985823	2	1	276	1	0	0	0	0	0	0	0	1	3708	1219	43	4		4	COL4A4	2	227985823	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3225552	227985823	15213550	318	50207											
COL4A3	1285	broad.mit.edu	37	chr2	228172461	228172461	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggattgccaggtttgaaaGgaaaacgtggagacagtgga	14	8	15	4	1	0	2	0	1	0	1	0	6	0	5	1	5	2	1	1	5	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:228172461G>A	uc002vom.1	+	48	4450	c.4288G>A	c.(4288-4290)GGA>AGA	p.G1430R	COL4A3_uc002von.1_Missense_Mutation_p.G1430R|COL4A3_uc002voo.1_Missense_Mutation_p.G1430R|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron|COL4A3_uc010fxf.1_5'UTR	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1430	Triple-helical region.|Epitope recognized by Goodpasture antibodies.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AGGTTTGAAAGGAAAACGTGG	0.433													16	66					0	0	0	0	A	228172461	A	A	228172461	3	1	276	1	0	0	0	0	1	0	0	0	3706	1001	35	4	4478	4	COL4A3	2	228172461	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	186638	228172461	15026912	319	50208											
AGFG1	3267	broad.mit.edu	37	chr2	228398379	228398379	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagtcatcaaacagcatcagCtgttagtaaagtttcaacga	15	10	8	8	1	4	0	4	0	0	0	4	2	4	0	0	0	4	5	0	0	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:228398379C>T	uc002vpc.2	+	7	1179	c.929C>T	c.(928-930)GCT>GTT	p.A310V	AGFG1_uc002vpd.2_Missense_Mutation_p.A334V|AGFG1_uc002vpe.2_Missense_Mutation_p.A310V|AGFG1_uc002vpf.2_Missense_Mutation_p.A270V	NM_004504	NP_004495	P52594	AGFG1_HUMAN	HIV-1 Rev binding protein isoform 2	310					cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4						ACAGCATCAGCTGTTAGTAAA	0.398													31	51					0	0	0	0	T	228398379	T	T	228398379	3	4	276	1	0	0	0	0	1	0	0	0	380	797	28	4	1031	4	AGFG1	2	228398379	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	225918	228398379	14800994	320	50209											
SPHKAP	80309	broad.mit.edu	37	chr2	228883697	228883697	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attaggccttgttaaaaccaGagcagcctccttgagcaatc	12	10	8	11	0	0	2	0	1	0	1	2	2	1	2	4	1	4	3	4	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:228883697G>A	uc002vpq.2	-	7	1920	c.1873C>T	c.(1873-1875)CTG>TTG	p.L625L	SPHKAP_uc002vpp.2_Silent_p.L625L|SPHKAP_uc010zlx.1_Silent_p.L625L	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	625						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GTTAAAACCAGAGCAGCCTCC	0.502													7	28					0	0	0	0	A	228883697	A	A	228883697	2	1	276	1	0	0	0	0	0	0	0	1	15114	933	33	2		2	SPHKAP	2	228883697	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	485318	228883697	14315676	321	50210											
TRIP12	9320	broad.mit.edu	37	chr2	230643188	230643198	+	Frame_Shift_Del	DEL	TAAGAAGCGAA	-	-																															gccttggccattaattttccTaagaagcgaaacttcatctt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:230643188_230643198delTAAGAAGCGAA	uc002vpw.1	-	35	5199_5209	c.5090_5100delTTCGCTTCTTA	c.(5089-5100)TTTCGCTTCTTAfs	p.F1697fs	TRIP12_uc002vpx.1_Frame_Shift_Del_p.F1745fs|TRIP12_uc002vpy.1_Frame_Shift_Del_p.F1427fs	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1697_1700					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TTAATTTTCCTAAGAAGCGAAACTTCATCTT	0.427													---	---	---								-	230643198	-	-	230643188	7	5	276	1	0	1	0	1	0	0	0	0	16623	1519	53	0	906	0	TRIP12	2	230643188	Frame_Shift_Del	DEL	TAAGAAGCGAA	TCGA-D6-6516-01A-11D-1870-08	1759491	230643188	12556185	322	50211											
NEU2	4759	broad.mit.edu	37	chr2	233899488	233899488	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccgctcggggcctggctcCccagcccagtggctgctcta	3	7	12	19	2	1	0	0	0	1	0	3	0	2	0	6	4	2	4	6	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:233899488C>T	uc010zmn.1	+	2	864	c.864C>T	c.(862-864)TCC>TCT	p.S288S		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	288							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		GGCCTGGCTCCCCAGCCCAGT	0.697													9	46					0	0	0	0	T	233899488	T	T	233899488	2	4	276	1	0	0	0	0	0	0	0	1	10396	610	22	4		4	NEU2	2	233899488	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3256300	233899488	9299885	323	50212											
ARL4C	10123	broad.mit.edu	37	chr2	235404769	235404769	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacgccggctggacgtgataGgtggtggccgggataagctc	7	7	17	10	4	0	1	0	1	0	0	1	3	0	3	2	6	1	2	2	6	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:235404769G>A	uc002vvn.2	-	1	925	c.462C>T	c.(460-462)ACC>ACT	p.T154T	ARL4C_uc002vvm.3_Silent_p.T154T	NM_005737	NP_005728	P56559	ARL4C_HUMAN	ADP-ribosylation factor-like 4C	154					endocytic recycling|small GTPase mediated signal transduction	cytoplasm|filopodium|nucleus|plasma membrane	alpha-tubulin binding|GTP binding|GTPase activity			skin(1)	1		Breast(86;0.000596)|Renal(207;0.00339)|all_lung(227;0.00354)|all_hematologic(139;0.0494)|Lung NSC(271;0.0496)|Lung SC(224;0.164)|all_neural(83;0.173)		Epithelial(121;2.6e-19)|BRCA - Breast invasive adenocarcinoma(100;0.000296)|Lung(119;0.002)|LUSC - Lung squamous cell carcinoma(224;0.0048)		GGACGTGATAGGTGGTGGCCG	0.622													6	32					0	0	0	0	A	235404769	A	A	235404769	2	1	276	1	0	0	0	0	0	0	0	1	939	987	35	4		4	ARL4C	2	235404769	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1505281	235404769	7794604	324	50213											
AGAP1	116987	broad.mit.edu	37	chr2	236708049	236708049	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtttaagcgactattcctcCtccgttccatcgactcccag	8	12	6	15	3	0	0	0	0	0	0	6	2	5	0	5	0	1	2	5	0	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:236708049C>T	uc002vvs.2	+	8	1435	c.840C>T	c.(838-840)TCC>TCT	p.S280S	AGAP1_uc002vvt.2_Silent_p.S280S	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	280					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						ACTATTCCTCCTCCGTTCCAT	0.512													17	61					0	0	0	0	T	236708049	T	T	236708049	2	4	276	1	0	0	0	0	0	0	0	1	366	668	24	4		4	AGAP1	2	236708049	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1303280	236708049	6491324	325	50214											
IQCA1	79781	broad.mit.edu	37	chr2	237272434	237272434	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatccataccttgaagactgCatgcagcatcatttggaggc	12	10	9	10	0	1	2	1	1	0	1	2	3	2	3	2	2	4	3	2	2	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:237272434C>T	uc002vvz.1	-	15	2040	c.1858G>A	c.(1858-1860)GCA>ACA	p.A620T	IQCA1_uc002vwb.2_Missense_Mutation_p.A628T|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Missense_Mutation_p.A579T	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	620							ATP binding			ovary(1)	1						TTGAAGACTGCATGCAGCATC	0.448													17	112					0	0	0	0	T	237272434	T	T	237272434	3	4	276	1	0	0	0	0	1	0	0	0	7841	710	25	4	630	4	IQCA1	2	237272434	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	564385	237272434	5926939	326	50215											
PER2	8864	broad.mit.edu	37	chr2	239170870	239170871	+	Missense_Mutation	DNP	CC	TT	TT																															ccaatgatgaaggagattttCctgctccatgggttgatgaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:239170870_239170871CC>TT	uc002vyc.2	-	11	1505_1506	c.1268_1269GG>AA	c.(1267-1269)AGG>AAA	p.R423K	PER2_uc010znv.1_Missense_Mutation_p.R423K|PER2_uc010znw.1_Missense_Mutation_p.R423K|PER2_uc010fyx.1_Missense_Mutation_p.E388K	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	423	PAC.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		AGGAGATTTTCCTGCTCCATGG	0.594													13	43					0	0	0	0	TT	239170871	TT	TT	239170870	3	4	276	1	0	0	0	0	1	0	0	0	11784	854	30	2	2550	2	PER2	2	239170870	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1898436	239170870	4028503	327	50216											
HDLBP	3069	broad.mit.edu	37	chr2	242178142	242178142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctggattctggaacctttggGgcccatgacagatcgatgga	9	10	13	9	1	1	2	0	1	1	1	2	6	1	5	2	5	1	0	2	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:242178142G>A	uc002waz.2	-	20	2899	c.2671C>T	c.(2671-2673)CCC>TCC	p.P891S	HDLBP_uc002wba.2_Missense_Mutation_p.P891S|HDLBP_uc002wbb.2_Missense_Mutation_p.P843S	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	891	KH 11.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		GAACCTTTGGGGCCCATGACA	0.473													65	317					0	0	0	0	A	242178142	A	A	242178142	3	1	276	1	0	0	0	0	1	0	0	0	7064	1232	43	4	1171	4	HDLBP	2	242178142	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3007272	242178142	1021231	328	50217											
THAP4	51078	broad.mit.edu	37	chr2	242576370	242576370	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgtacctgtggaaggagacGgcgcgcttctcgccctttcc	5	9	13	14	5	1	1	0	0	1	1	3	3	2	2	3	3	1	2	3	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr2:242576370G>C	uc002wbt.2	-	1	286	c.63C>G	c.(61-63)GCC>GCG	p.A21A	ATG4B_uc002wbu.2_5'Flank|ATG4B_uc002wbv.2_5'Flank|ATG4B_uc002wbw.2_5'Flank|ATG4B_uc010zox.1_5'Flank|ATG4B_uc010zoy.1_5'Flank|ATG4B_uc010fzp.2_5'Flank	NM_015963	NP_057047	Q8WY91	THAP4_HUMAN	THAP domain containing 4 isoform 1	21	THAP-type.						DNA binding|metal ion binding				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		GGAAGGAGACGGCGCGCTTCT	0.413													6	8					0	0	0	0	C	242576370	C	C	242576370	2	2	276	1	0	0	0	0	0	0	0	1	15912	1103	39	3		3	THAP4	2	242576370	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	398228	242576370	623003	329	50218											
CHL1	10752	broad.mit.edu	37	chr3	383653	383653	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccaaaagggagatctataCttcgcaaacgtggaagaaaa	18	6	10	7	2	1	2	0	0	1	2	2	4	1	3	1	2	3	1	1	2	8	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:383653C>T	uc003bou.2	+	7	838	c.567C>T	c.(565-567)TAC>TAT	p.Y189Y	CHL1_uc003bot.2_Silent_p.Y189Y|CHL1_uc003bow.1_Silent_p.Y189Y|CHL1_uc011asi.1_Silent_p.Y189Y	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	189	Ig-like C2-type 2.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GAGATCTATACTTCGCAAACG	0.383													4	17					0	0	0	0	T	383653	T	T	383653	2	4	276	1	0	0	0	0	0	0	0	1	3364	576	20	4		4	CHL1	3	383653	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08		383653	197638777	330	50219											
CNTN4	152330	broad.mit.edu	37	chr3	2777999	2777999	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgaagctcaattgtgaagtTaaaggaaatccaaaacctca	17	9	8	7	0	2	2	2	2	0	0	3	3	3	3	2	1	2	2	2	1	8	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:2777999T>A	uc003bpc.2	+	4	377	c.156T>A	c.(154-156)GTT>GTA	p.V52V	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Silent_p.V52V	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	52	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ATTGTGAAGTTAAAGGAAATC	0.343													17	52					0	0	0	0	A	2777999	A	A	2777999	2	1	276	1	0	0	0	0	0	0	0	1	3658	1741	61	5		5	CNTN4	3	2777999	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	2394346	2777999	195244431	331	50220											
SUMF1	285362	broad.mit.edu	37	chr3	4461817	4461817	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctttcacaggtaaccaccagGgagcagctgcaacctcaaag	13	6	9	13	0	2	0	2	0	0	0	2	1	2	1	3	2	5	4	3	2	3	2	rs113185435		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:4461817G>A	uc003bpz.1	-	4	558	c.533C>T	c.(532-534)CCC>CTC	p.P178L	SUMF1_uc003bps.1_RNA|SUMF1_uc011ass.1_Missense_Mutation_p.P153L|SUMF1_uc010hby.1_Missense_Mutation_p.P178L|SUMF1_uc011ast.1_Intron	NM_182760	NP_877437	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1 isoform 1	178						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			upper_aerodigestive_tract(1)	1		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		TAACCACCAGGGAGCAGCTGC	0.483													9	30					0	0	0	0	A	4461817	A	A	4461817	3	1	276	1	0	0	0	0	1	0	0	0	15451	1232	43	4	615	4	SUMF1	3	4461817	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1683818	4461817	193560613	332	50221											
ITPR1	3708	broad.mit.edu	37	chr3	4808218	4808218	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggattttcctttgcagcactCctttttctgtcgcttgacag	5	17	8	11	1	1	1	0	1	1	0	4	2	3	2	2	1	2	3	2	1	0	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:4808218C>T	uc003bqa.2	+	42	5753	c.5405C>T	c.(5404-5406)TCC>TTC	p.S1802F	ITPR1_uc010hca.1_Missense_Mutation_p.S1787F|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.S772F	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	1850	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TTGCAGCACTCCTTTTTCTGT	0.428													9	45					0	0	0	0	T	4808218	T	T	4808218	3	4	276	1	0	0	0	0	1	0	0	0	7959	855	30	2	5719	2	ITPR1	3	4808218	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	346401	4808218	193214212	333	50222											
ITPR1	3708	broad.mit.edu	37	chr3	4836803	4836803	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctttctggagcagcatttCgtttaacctggccgtcctga	6	14	10	11	2	2	1	0	1	2	0	4	2	3	2	3	2	3	3	3	2	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:4836803C>T	uc003bqa.2	+	50	7067	c.6719C>T	c.(6718-6720)TCG>TTG	p.S2240L	ITPR1_uc010hca.1_Missense_Mutation_p.S2225L|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.S1210L|ITPR1_uc010hcc.1_Missense_Mutation_p.S8L	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2288	Helical; (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGCAGCATTTCGTTTAACCTG	0.527													4	27					0	0	0	0	T	4836803	T	T	4836803	3	4	276	1	0	0	0	0	1	0	0	0	7959	893	31	1	7065	1	ITPR1	3	4836803	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	28585	4836803	193185627	334	50223											
RPUSD3	285367	broad.mit.edu	37	chr3	9882388	9882388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccagcacctctcaccagtagGtggctgtgggcctttgggct	5	10	13	13	0	1	0	1	0	1	0	2	0	1	0	4	4	1	4	4	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:9882388G>A	uc011atk.1	-	5	513	c.509C>T	c.(508-510)ACC>ATC	p.T170I	ARPC4_uc003btc.1_Intron|RPUSD3_uc011atl.1_Missense_Mutation_p.T155I|RPUSD3_uc011atm.1_Missense_Mutation_p.T162I|RPUSD3_uc003btn.2_3'UTR	NM_173659	NP_775930	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	170					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(1)	1	Medulloblastoma(99;0.227)					TCACCAGTAGGTGGCTGTGGG	0.597													8	35					0	0	0	0	A	9882388	A	A	9882388	3	1	276	1	0	0	0	0	1	0	0	0	13733	1261	44	4	566	4	RPUSD3	3	9882388	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5045585	9882388	188140042	335	50224											
CRELD1	78987	broad.mit.edu	37	chr3	9982847	9982847	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgaggaatcaaactgtttGcaatgcaagaagggctgggc	12	8	13	8	0	1	2	1	1	0	1	1	3	1	3	1	3	3	4	1	3	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:9982847G>T	uc003bug.2	+	7	808	c.690G>T	c.(688-690)TTG>TTT	p.L230F	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Missense_Mutation_p.L230F|CRELD1_uc003buh.2_Missense_Mutation_p.L230F|CRELD1_uc003bui.2_Missense_Mutation_p.L230F|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	230	FU 1.|Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						CAAACTGTTTGCAATGCAAGA	0.592													21	58					1.9806e-07	2.01719e-07	1	0	T	9982847	T	T	9982847	3	4	276	1	0	0	0	0	1	0	0	0	3881	1310	46	4	712	4	CRELD1	3	9982847	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	100459	9982847	188039583	336	50225											
TIMP4	7079	broad.mit.edu	37	chr3	12198975	12198975	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctcactggagattttggcCcgaatcactgcataggaaga	11	11	10	9	1	2	2	2	0	1	2	3	5	2	3	1	3	1	1	1	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:12198975C>T	uc003bwo.2	-	2	454	c.147G>A	c.(145-147)CGG>CGA	p.R49R	SYN2_uc003bwl.1_Intron|SYN2_uc003bwm.2_Intron|SYN2_uc003bwn.2_Intron	NM_003256	NP_003247	Q99727	TIMP4_HUMAN	tissue inhibitor of metalloproteinase 4	49	NTR.						metal ion binding|metalloendopeptidase inhibitor activity				0						AGATTTTGGCCCGAATCACTG	0.493													14	36					0	0	0	0	T	12198975	T	T	12198975	2	4	276	1	0	0	0	0	0	0	0	1	15986	610	22	4		4	TIMP4	3	12198975	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2216128	12198975	185823455	337	50226											
NUP210	23225	broad.mit.edu	37	chr3	13407500	13407500	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcactcaggtggacgtggccGtgtctgtagctcacaagaag	9	8	14	10	2	3	1	2	0	1	1	3	2	3	2	1	3	1	3	1	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:13407500G>A	uc003bxv.1	-	14	1961	c.1878C>T	c.(1876-1878)CAC>CAT	p.H626H	NUP210_uc003bxx.2_Silent_p.H298H	NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	626	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GGACGTGGCCGTGTCTGTAGC	0.637													9	34					0	0	0	0	A	13407500	A	A	13407500	2	1	276	1	0	0	0	0	0	0	0	1	10814	1136	40	1		1	NUP210	3	13407500	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1208525	13407500	184614930	338	50227											
TBC1D5	9779	broad.mit.edu	37	chr3	17226675	17226675	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcaactgcccttgaaggaagGaaatttgggcttctaattct	11	13	9	8	0	3	1	1	1	2	0	3	3	3	3	1	3	2	1	1	3	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:17226675G>A	uc003cbf.2	-	19	3443	c.1778C>T	c.(1777-1779)TCC>TTC	p.S593F	TBC1D5_uc010heu.2_Missense_Mutation_p.S180F|TBC1D5_uc010hev.2_Missense_Mutation_p.S615F|TBC1D5_uc003cbe.2_Missense_Mutation_p.S593F|TBC1D5_uc010hew.1_Missense_Mutation_p.S567F	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	593						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						TTGAAGGAAGGAAATTTGGGC	0.368													7	39					0	0	0	0	A	17226675	A	A	17226675	3	1	276	1	0	0	0	0	1	0	0	0	15689	1174	41	2	625	2	TBC1D5	3	17226675	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3819175	17226675	180795755	339	50228											
KAT2B	8850	broad.mit.edu	37	chr3	20113935	20113935	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctaacagaatcctgtcggagTtgtagccatgccctaggtga	10	10	11	10	1	0	2	0	1	0	1	2	3	1	3	3	2	3	2	3	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:20113935T>C	uc003cbq.2	+	2	860	c.414T>C	c.(412-414)AGT>AGC	p.S138S		NM_003884	NP_003875	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	138					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCTGTCGGAGTTGTAGCCATG	0.458													21	85					0	0	0	0	C	20113935	C	C	20113935	2	2	276	1	0	0	0	0	0	0	0	1	8021	1722	60	5		5	KAT2B	3	20113935	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	2887260	20113935	177908495	340	50229											
RARB	5915	broad.mit.edu	37	chr3	25542804	25542804	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgctttgaagtgggaatGtccaaagaatgtaagtggag	14	10	14	3	0	0	2	0	1	0	1	1	4	1	4	1	2	1	2	1	2	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:25542804G>T	uc011awl.1	+	3	525	c.459G>T	c.(457-459)ATG>ATT	p.M153I	RARB_uc003cdi.1_Missense_Mutation_p.M34I|RARB_uc003cdh.2_Missense_Mutation_p.M146I	NM_016152	NP_057236	P10826	RARB_HUMAN	retinoic acid receptor, beta isoform 2	153	Nuclear receptor.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	AAGTGGGAATGTCCAAAGAAT	0.403													10	20					7.48243e-07	7.60844e-07	1	0	T	25542804	T	T	25542804	3	4	276	1	0	0	0	0	1	0	0	0	13118	1377	48	4	448	4	RARB	3	25542804	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5428869	25542804	172479626	341	50230											
RBMS3	27303	broad.mit.edu	37	chr3	29938882	29938882	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttgcagattttattcttcAccgtacagtattgcaaccaa	11	15	6	9	1	2	1	1	0	1	1	2	1	2	1	2	0	4	5	2	0	5	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:29938882A>C	uc003cel.2	+	9	1034	c.804A>C	c.(802-804)TCA>TCC	p.S268S	RBMS3_uc003cek.2_Silent_p.S268S|RBMS3_uc010hfq.2_Silent_p.S281S|RBMS3_uc003cem.2_Silent_p.S267S|RBMS3_uc010hfr.2_Silent_p.S268S	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	268						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				TTTATTCTTCACCGTACAGTA	0.433													31	93					0	0	0	0	C	29938882	C	C	29938882	2	2	276	1	0	0	0	0	0	0	0	1	13215	146	6	5		5	RBMS3	3	29938882	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	4396078	29938882	168083548	342	50231											
CCR4	1233	broad.mit.edu	37	chr3	32995339	32995339	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atacctggcaattgtgcacgCggtgttttccttgagggcaa	8	12	12	9	2	0	1	0	1	0	0	1	1	1	1	2	3	2	4	2	3	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:32995339C>T	uc003cfg.1	+	2	593	c.425C>T	c.(424-426)GCG>GTG	p.A142V		NM_005508	NP_005499	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	142	Cytoplasmic (Potential).				chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				lung(1)	1						ATTGTGCACGCGGTGTTTTCC	0.488													40	126					0	0	0	0	T	32995339	T	T	32995339	3	4	276	1	0	0	0	0	1	0	0	0	2958	768	27	1	427	1	CCR4	3	32995339	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3056457	32995339	165027091	343	50232											
GLB1	2720	broad.mit.edu	37	chr3	33058317	33058318	+	Missense_Mutation	DNP	GG	AA	AA																															gatcacattgtttcgctcaaGgactccctgggggatctgtg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:33058317_33058318GG>AA	uc003cfi.1	-	14	1479_1480	c.1362_1363CC>TT	c.(1360-1365)GTCCTT>GTTTTT	p.L455F	GLB1_uc003cfh.1_Missense_Mutation_p.L425F|GLB1_uc003cfj.1_Missense_Mutation_p.L324F|GLB1_uc011axk.1_Missense_Mutation_p.L503F	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	455					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				TTTCGCTCAAGGACTCCCTGGG	0.48													14	60					0	0	0	0	AA	33058318	AA	AA	33058317	3	1	276	1	0	0	0	0	1	0	0	0	6464	1000	35	4	682	4	GLB1	3	33058317	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	62978	33058317	164964113	344	50233											
GLB1	2720	broad.mit.edu	37	chr3	33109732	33109733	+	Missense_Mutation	DNP	GG	AA	AA																															aacaacctacctgggtcggaGgagcggagaagaatagactc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:33109732_33109733GG>AA	uc003cfi.1	-	4	563_564	c.446_447CC>TT	c.(445-447)TCC>TTT	p.S149F	GLB1_uc003cfh.1_Missense_Mutation_p.S119F|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Missense_Mutation_p.S197F	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	149			S -> F (in MPS4B; 2.0% of wild-type enzyme activity).		carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				CTGGGTCGGAGGAGCGGAGAAG	0.361													14	52					0	0	0	0	AA	33109733	AA	AA	33109732	3	1	276	1	0	0	0	0	1	0	0	0	6464	987	35	4	1638	4	GLB1	3	33109732	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	51415	33109732	164912698	345	50234											
SUSD5	26032	broad.mit.edu	37	chr3	33194670	33194670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tggtgagctcataggacaggGtggccatgggagattcctct	8	10	15	8	0	2	2	1	1	1	1	3	4	3	3	2	5	1	1	2	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:33194670G>A	uc003cfo.1	-	5	1872	c.1454C>T	c.(1453-1455)ACC>ATC	p.T485I		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	485	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						ATAGGACAGGGTGGCCATGGG	0.522													7	30					0	0	0	0	A	33194670	A	A	33194670	3	1	276	1	0	0	0	0	1	0	0	0	15477	1261	44	4	439	4	SUSD5	3	33194670	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	84938	33194670	164827760	346	50235											
EPM2AIP1	9852	broad.mit.edu	37	chr3	37033026	37033026	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgtattcattccaaagatTagtgtttgcctgaagttttg	9	18	8	6	0	2	2	1	1	1	1	3	2	3	2	2	0	1	3	2	0	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:37033026T>C	uc003cgk.2	-	1	1770	c.1543A>G	c.(1543-1545)AAT>GAT	p.N515D	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	515						endoplasmic reticulum					0						TTCCAAAGATTAGTGTTTGCC	0.383													6	13					0	0	0	0	C	37033026	C	C	37033026	3	2	276	1	0	0	0	0	1	0	0	0	5208	1754	61	5	284	5	EPM2AIP1	3	37033026	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	3838356	37033026	160989404	347	50236											
DLEC1	9940	broad.mit.edu	37	chr3	38087117	38087117	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccaagcacgggctattgcGgaaaatgagcgggtcatgag	11	6	15	9	3	1	2	1	2	0	0	1	3	1	3	1	3	3	2	1	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:38087117G>A	uc003cho.1	+	2	516	c.495G>A	c.(493-495)GCG>GCA	p.A165A	DLEC1_uc003chp.1_Silent_p.A165A|DLEC1_uc010hgv.1_Silent_p.A165A	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	165					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GGGCTATTGCGGAAAATGAGC	0.473													11	41					0	0	0	0	A	38087117	A	A	38087117	2	1	276	1	0	0	0	0	0	0	0	1	4574	1103	39	1		1	DLEC1	3	38087117	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1054091	38087117	159935313	348	50237											
XYLB	9942	broad.mit.edu	37	chr3	38409713	38409713	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagctttgctgcttccctgtTccttggctcttactccccta	3	17	6	15	0	1	0	0	0	1	0	4	0	4	0	4	1	4	5	4	1	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:38409713T>C	uc003cic.2	+	8	720	c.611T>C	c.(610-612)TTC>TCC	p.F204S	XYLB_uc011ayp.1_Missense_Mutation_p.F67S|XYLB_uc003cid.1_Missense_Mutation_p.F126S	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	204					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		GCTTCCCTGTTCCTTGGCTCT	0.517													29	82					0	0	0	0	C	38409713	C	C	38409713	3	2	276	1	0	0	0	0	1	0	0	0	17530	1783	62	5	641	5	XYLB	3	38409713	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	322596	38409713	159612717	349	50238											
SCN5A	6331	broad.mit.edu	37	chr3	38639322	38639322	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgcacatagtgatggtgagGtcagtaaacgggtccatgac	12	9	13	7	1	1	3	1	3	0	0	2	3	2	3	1	3	2	2	1	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:38639322G>T	uc003cio.2	-	14	2354	c.2160C>A	c.(2158-2160)GAC>GAA	p.D720E	SCN5A_uc003cin.2_Missense_Mutation_p.D720E|SCN5A_uc003cil.3_Missense_Mutation_p.D720E|SCN5A_uc010hhi.2_Missense_Mutation_p.D720E|SCN5A_uc010hhk.2_Missense_Mutation_p.D720E|SCN5A_uc011ayr.1_Missense_Mutation_p.D720E|SCN5A_uc010hhj.1_Missense_Mutation_p.D331E	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	720	Helical; Name=S1 of repeat II; (Potential).				blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGATGGTGAGGTCAGTAAACG	0.547													6	54					0.00116845	0.00117961	1	0	T	38639322	T	T	38639322	3	4	276	1	0	0	0	0	1	0	0	0	13987	1252	44	4	3950	4	SCN5A	3	38639322	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	229609	38639322	159383108	350	50239											
SCN10A	6336	broad.mit.edu	37	chr3	38739520	38739520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	actcaggggctcagtgctctCctccgtggccacattgaagt	7	10	11	13	1	3	1	2	1	1	0	5	1	4	1	3	3	1	2	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:38739520C>T	uc003ciq.2	-	27	5191	c.5191G>A	c.(5191-5193)GAG>AAG	p.E1731K		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1731					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCAGTGCTCTCCTCCGTGGCC	0.478													10	40					0	0	0	0	T	38739520	T	T	38739520	3	4	276	1	0	0	0	0	1	0	0	0	13977	864	30	2	683	2	SCN10A	3	38739520	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	100198	38739520	159282910	351	50240											
SCN10A	6336	broad.mit.edu	37	chr3	38743591	38743591	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgtcaaagacaaaaccctGgaacttgttctgagaaaaca	17	8	8	8	0	2	2	1	1	1	2	2	5	2	3	1	1	3	1	1	1	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:38743591G>A	uc003ciq.2	-	26	4396	c.4396C>T	c.(4396-4398)CAG>TAG	p.Q1466*		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1466					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ACAAAACCCTGGAACTTGTTC	0.463													7	30					0	0	0	0	A	38743591	A	A	38743591	4	1	276	1	0	0	0	0	0	1	0	0	13977	1357	47	4	1482	4	SCN10A	3	38743591	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4071	38743591	159278839	352	50241											
SCN10A	6336	broad.mit.edu	37	chr3	38748836	38748836	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatggcattgtagtatttCttctgctcctctgtcatgaa	7	18	7	9	0	5	1	2	1	3	0	6	1	6	1	1	1	1	4	1	1	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:38748836C>T	uc003ciq.2	-	25	4320	c.4320G>A	c.(4318-4320)AAG>AAA	p.K1440K		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1440					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGTAGTATTTCTTCTGCTCCT	0.537													47	100					0	0	0	0	T	38748836	T	T	38748836	2	4	276	1	0	0	0	0	0	0	0	1	13977	912	32	2		2	SCN10A	3	38748836	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5245	38748836	159273594	353	50242											
CCR3	1232	broad.mit.edu	37	chr3	46306731	46306731	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctgctctgtgaaaaagctGataccagagcactgatggcc	11	8	11	11	0	1	4	0	3	1	1	1	4	1	4	3	1	4	3	3	1	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:46306731G>A	uc003cpg.1	+	4	625	c.82G>A	c.(82-84)GAT>AAT	p.D28N	CCR3_uc003cpi.1_Missense_Mutation_p.D28N|CCR3_uc003cpj.1_Missense_Mutation_p.D28N|CCR3_uc003cpk.1_Missense_Mutation_p.D49N|CCR3_uc010hjb.1_Missense_Mutation_p.D46N|CCR3_uc003cpl.1_Missense_Mutation_p.D61N	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	28	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		TGAAAAAGCTGATACCAGAGC	0.502													6	21					0	0	0	0	A	46306731	A	A	46306731	3	1	276	1	0	0	0	0	1	0	0	0	2957	1290	45	2	151	2	CCR3	3	46306731	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7557895	46306731	151715699	354	50243											
NBEAL2	23218	broad.mit.edu	37	chr3	47037517	47037517	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catctggtcaagacagcaccCcttcgctgcccctccctcag	7	8	7	19	1	3	1	2	0	1	1	5	1	4	1	5	1	2	2	5	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:47037517C>T	uc003cqp.2	+	15	2306	c.2127C>T	c.(2125-2127)CCC>CCT	p.P709P	NBEAL2_uc010hjm.1_Silent_p.P270P	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	709							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		AGACAGCACCCCTTCGCTGCC	0.607													4	11					0	0	0	0	T	47037517	T	T	47037517	2	4	276	1	0	0	0	0	0	0	0	1	10242	610	22	4		4	NBEAL2	3	47037517	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	730786	47037517	150984913	355	50244											
KLHL18	23276	broad.mit.edu	37	chr3	47378140	47378140	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgtggtgaacgggcttctCtatgccatcggaggatatga	8	11	14	8	2	1	2	0	2	1	0	3	4	1	4	1	4	2	2	1	4	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:47378140C>T	uc003crd.2	+	7	1140	c.1014C>T	c.(1012-1014)CTC>CTT	p.L338L	KLHL18_uc003crc.2_Silent_p.L338L|KLHL18_uc011bav.1_Silent_p.L226L|KLHL18_uc010hjq.1_Silent_p.L194L	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	338	Kelch 2.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		ACGGGCTTCTCTATGCCATCG	0.592													15	26					0	0	0	0	T	47378140	T	T	47378140	2	4	276	1	0	0	0	0	0	0	0	1	8412	900	32	2		2	KLHL18	3	47378140	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	340623	47378140	150644290	356	50245											
PLXNB1	5364	broad.mit.edu	37	chr3	48447184	48447185	+	Missense_Mutation	DNP	CC	TT	TT																															ttcatgcagggccactcgcgCcccgaggtctccggagtagt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:48447184_48447185CC>TT	uc003csw.2	-	37	6519_6520	c.6249_6250GG>AA	c.(6247-6252)GGGGCG>GGAACG	p.A2084T	PLXNB1_uc003cst.2_Missense_Mutation_p.A534T|PLXNB1_uc003csu.2_Missense_Mutation_p.A1901T|PLXNB1_uc003csx.2_Missense_Mutation_p.A2084T	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	2084	Cytoplasmic (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCCACTCGCGCCCCGAGGTCTC	0.614													9	25					0	0	0	0	TT	48447185	TT	TT	48447184	3	4	276	1	0	0	0	0	1	0	0	0	12178	739	26	4	165	4	PLXNB1	3	48447184	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1069044	48447184	149575246	357	50246											
CELSR3	1951	broad.mit.edu	37	chr3	48677667	48677667	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccgtggcagggtgctgccCcgatctttgggctccagtcg	3	10	14	14	3	1	0	0	0	1	0	4	1	3	0	4	3	2	3	4	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:48677667C>T	uc003cul.2	-	34	9632	c.9351G>A	c.(9349-9351)CGG>CGA	p.R3117R	CELSR3_uc003cuf.1_Silent_p.R3215R|CELSR3_uc010hkf.2_Silent_p.R407R|CELSR3_uc010hkg.2_Silent_p.R1100R	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	3117	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGGTGCTGCCCCGATCTTTGG	0.677													19	33					0	0	0	0	T	48677667	T	T	48677667	2	4	276	1	0	0	0	0	0	0	0	1	3238	610	22	4		4	CELSR3	3	48677667	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	230483	48677667	149344763	358	50247											
CELSR3	1951	broad.mit.edu	37	chr3	48681721	48681721	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcgaggagaaacatggtcCcgttcatctggacccacggc	10	6	12	13	3	2	1	1	0	1	1	3	4	3	2	2	4	2	1	2	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:48681721C>T	uc003cul.2	-	27	8374	c.8093G>A	c.(8092-8094)GGG>GAG	p.G2698E	CELSR3_uc003cuf.1_Missense_Mutation_p.G2795E|CELSR3_uc010hkf.2_5'Flank|CELSR3_uc010hkg.2_Missense_Mutation_p.G681E	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2698	Helical; Name=5; (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AAACATGGTCCCGTTCATCTG	0.502													11	30					0	0	0	0	T	48681721	T	T	48681721	3	4	276	1	0	0	0	0	1	0	0	0	3238	623	22	4	1881	4	CELSR3	3	48681721	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4054	48681721	149340709	359	50248											
CELSR3	1951	broad.mit.edu	37	chr3	48685393	48685393	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtagcgacgggccccccggGgagaactggggtgctccatg	6	5	18	12	3	0	1	0	0	0	1	1	3	1	1	4	6	3	2	4	6	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:48685393G>A	uc003cul.2	-	20	7291	c.7010C>T	c.(7009-7011)CCC>CTC	p.P2337L	CELSR3_uc003cuf.1_Missense_Mutation_p.P2407L|CELSR3_uc010hkg.2_Missense_Mutation_p.P320L	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2337	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGCCCCCCGGGGAGAACTGGG	0.617													33	92					0	0	0	0	A	48685393	A	A	48685393	3	1	276	1	0	0	0	0	1	0	0	0	3238	1232	43	4	2992	4	CELSR3	3	48685393	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3672	48685393	149337037	360	50249											
HYAL3	8372	broad.mit.edu	37	chr3	50332191	50332191	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgaggcggacataggccagGacaggcaggggatgtcggtg	9	5	20	7	2	0	1	0	1	0	0	1	4	0	4	1	8	0	1	1	8	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:50332191G>A	uc003czd.1	-	2	1116	c.843C>T	c.(841-843)GTC>GTT	p.V281V	HYAL3_uc003czc.1_Silent_p.V281V|HYAL3_uc003cze.1_Silent_p.V32V|HYAL3_uc003czf.1_Silent_p.V32V|HYAL3_uc003czg.1_Silent_p.V281V	NM_003549	NP_003540	O43820	HYAL3_HUMAN	hyaluronoglucosaminidase 3 precursor	281					carbohydrate metabolic process	extracellular region|lysosome	hyalurononglucosaminidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		CATAGGCCAGGACAGGCAGGG	0.637													17	43					0	0	0	0	A	50332191	A	A	50332191	2	1	276	1	0	0	0	0	0	0	0	1	7504	1161	41	2		2	HYAL3	3	50332191	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1646798	50332191	147690239	361	50250											
DOCK3	1795	broad.mit.edu	37	chr3	51394395	51394395	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctgtgtgcccctaggtGgaggtgagccctctggagaa	6	10	16	9	0	1	2	0	1	1	1	1	4	1	3	3	4	3	1	3	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:51394395G>A	uc011bds.1	+	44	4529	c.4506G>A	c.(4504-4506)GTG>GTA	p.V1502V		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1502	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GCCCCTAGGTGGAGGTGAGCC	0.517													4	10					0	0	0	0	A	51394395	A	A	51394395	2	1	276	1	0	0	0	0	0	0	0	1	4710	1335	47	4		4	DOCK3	3	51394395	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1062204	51394395	146628035	362	50251											
STAB1	23166	broad.mit.edu	37	chr3	52544384	52544384	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggctgagtgtgtccctgggtCcctgggcacccaccactgca	5	8	13	15	0	0	1	0	1	0	0	2	1	2	1	4	3	1	3	4	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:52544384C>T	uc003dej.2	+	25	2722	c.2648C>T	c.(2647-2649)TCC>TTC	p.S883F		NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	883	Extracellular (Potential).|EGF-like 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GTCCCTGGGTCCCTGGGCACC	0.602													14	46					0	0	0	0	T	52544384	T	T	52544384	3	4	276	1	0	0	0	0	1	0	0	0	15303	855	30	2	2746	2	STAB1	3	52544384	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1149989	52544384	145478046	363	50252											
STAB1	23166	broad.mit.edu	37	chr3	52554682	52554682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctgcagcatctgtgggctgGagccaccctgtcctgagggg	5	8	15	13	0	1	1	0	1	1	0	2	2	2	2	4	4	3	3	4	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:52554682G>A	uc003dej.2	+	54	5748	c.5674G>A	c.(5674-5676)GAG>AAG	p.E1892K	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1892	Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CTGTGGGCTGGAGCCACCCTG	0.647													25	60					0	0	0	0	A	52554682	A	A	52554682	3	1	276	1	0	0	0	0	1	0	0	0	15303	1175	41	2	5888	2	STAB1	3	52554682	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	10298	52554682	145467748	364	50253											
PBRM1	55193	broad.mit.edu	37	chr3	52676029	52676029	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagtgccattgtaattgctGataaacgacctccttgtact	11	13	8	9	1	0	1	0	1	0	0	1	3	1	1	3	0	4	3	3	0	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:52676029G>A	uc003des.2	-	10	1040	c.1028C>T	c.(1027-1029)TCA>TTA	p.S343L	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.S343L|PBRM1_uc003der.2_Missense_Mutation_p.S311L|PBRM1_uc003det.2_Missense_Mutation_p.S343L|PBRM1_uc003deu.2_Missense_Mutation_p.S343L|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.S343L|PBRM1_uc010hmk.1_Missense_Mutation_p.S343L|PBRM1_uc003dey.2_Missense_Mutation_p.S343L|PBRM1_uc003dez.1_Missense_Mutation_p.S343L|PBRM1_uc003dfb.1_Missense_Mutation_p.S241L	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	343					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TGTAATTGCTGATAAACGACC	0.368			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								37	144					0	0	0	0	A	52676029	A	A	52676029	3	1	276	1	0	0	0	0	1	0	0	0	11545	1294	45	2	3956	2	PBRM1	3	52676029	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	121347	52676029	145346401	365	50254											
ITIH3	3699	broad.mit.edu	37	chr3	52836770	52836770	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gggactacatcttcgggaatTacattgagcggctctgggcc	8	10	13	10	2	2	1	0	1	2	0	3	3	2	3	1	4	3	1	1	4	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:52836770T>C	uc003dfv.2	+	13	1693	c.1657T>C	c.(1657-1659)TAC>CAC	p.Y553H	ITIH3_uc011bek.1_Intron	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	553					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CTTCGGGAATTACATTGAGCG	0.617													6	24					0	0	0	0	C	52836770	C	C	52836770	3	2	276	1	0	0	0	0	1	0	0	0	7944	1754	61	5	1707	5	ITIH3	3	52836770	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	160741	52836770	145185660	366	50255											
RFT1	91869	broad.mit.edu	37	chr3	53157826	53157826	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cggaaggcctctctggccagGaagagggtggttgagtaaag	10	7	17	7	1	1	2	0	1	1	1	2	4	1	4	2	6	0	2	2	6	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:53157826G>A	uc003dgj.2	-	3	234	c.180C>T	c.(178-180)TTC>TTT	p.F60F	RFT1_uc003dgk.2_Intron	NM_052859	NP_443091	Q96AA3	RFT1_HUMAN	RFT1 homolog	60	Helical; (Potential).				carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		CTCTGGCCAGGAAGAGGGTGG	0.498													7	26					0	0	0	0	A	53157826	A	A	53157826	2	1	276	1	0	0	0	0	0	0	0	1	13322	1165	41	2		2	RFT1	3	53157826	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	321056	53157826	144864604	367	50256											
PRKCD	5580	broad.mit.edu	37	chr3	53221364	53221364	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctcttgcccaggttttatgCcgctgagataatgtgtggac	7	14	11	9	1	1	1	0	1	1	1	2	3	1	2	2	2	2	2	2	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:53221364C>T	uc003dgl.2	+	15	1714	c.1361C>T	c.(1360-1362)GCC>GTC	p.A454V	PRKCD_uc003dgm.2_Missense_Mutation_p.A454V	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	454	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		AGGTTTTATGCCGCTGAGATA	0.587													13	65					0	0	0	0	T	53221364	T	T	53221364	3	4	276	1	0	0	0	0	1	0	0	0	12571	739	26	4	1411	4	PRKCD	3	53221364	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	63538	53221364	144801066	368	50257											
ERC2	26059	broad.mit.edu	37	chr3	56183087	56183087	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtcctcagtgttcagcacaCcattggcttttaacatctgg	8	13	9	11	0	3	0	2	0	1	0	4	0	4	0	2	3	2	3	2	3	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:56183087C>T	uc003dhr.1	-	5	1479	c.1223G>A	c.(1222-1224)GGT>GAT	p.G408D		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	408	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTTCAGCACACCATTGGCTTT	0.403													17	43					0	0	0	0	T	56183087	T	T	56183087	3	4	276	1	0	0	0	0	1	0	0	0	5235	507	18	4	1692	4	ERC2	3	56183087	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2961723	56183087	141839343	369	50258											
PTPRG	5793	broad.mit.edu	37	chr3	62188887	62188887	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcagccgacatggcccccaTcagctcggggtcttctacct	6	10	9	16	2	4	0	2	0	2	0	5	1	4	0	4	3	3	1	4	3	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:62188887T>C	uc003dlb.2	+	12	2137	c.1418T>C	c.(1417-1419)ATC>ACC	p.I473T	PTPRG_uc003dlc.2_Missense_Mutation_p.I473T	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	473	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ATGGCCCCCATCAGCTCGGGG	0.587													21	68					0	0	0	0	C	62188887	C	C	62188887	3	2	276	1	0	0	0	0	1	0	0	0	12867	1435	50	5	1464	5	PTPRG	3	62188887	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	6005800	62188887	135833543	370	50259											
PTPRG	5793	broad.mit.edu	37	chr3	62257095	62257095	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagggtcgtcagaatgaaaGggtagtgatccagtatcact	13	9	12	7	1	2	3	2	2	0	1	4	3	3	3	1	2	0	2	1	2	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:62257095G>A	uc003dlb.2	+	21	3766	c.3047G>A	c.(3046-3048)AGG>AAG	p.R1016K	PTPRG_uc003dlc.2_Missense_Mutation_p.R987K|PTPRG_uc011bfi.1_Missense_Mutation_p.R262K|uc010hno.2_Intron|uc003dld.3_Intron|uc010hnp.2_Intron|uc003dle.3_Intron	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1016	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CAGAATGAAAGGGTAGTGATC	0.478													10	37					0	0	0	0	A	62257095	A	A	62257095	3	1	276	1	0	0	0	0	1	0	0	0	12867	1000	35	4	3129	4	PTPRG	3	62257095	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	68208	62257095	135765335	371	50260											
THOC7	80145	broad.mit.edu	37	chr3	63823658	63823658	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcaaaacccttaccttggcGattttttcgtattcgttttg	7	18	6	10	3	1	0	1	0	0	0	3	1	1	0	2	1	2	2	2	1	4	9			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:63823658G>A	uc003dlt.3	-	4	477	c.346C>T	c.(346-348)CGC>TGC	p.R116C	C3orf49_uc003dls.3_Intron|THOC7_uc003dlu.3_Missense_Mutation_p.R53C	NM_025075	NP_079351	Q6I9Y2	THOC7_HUMAN	Ngg1 interacting factor 3 like 1 binding protein	116	Potential.|Interaction with THOC5.|Interaction with NIF3L1.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	cytoplasm|THO complex part of transcription export complex	protein binding|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.000439)|Kidney(15;0.00194)|KIRC - Kidney renal clear cell carcinoma(15;0.00218)		TTACCTTGGCGATTTTTTCGT	0.348													29	69					0	0	0	0	A	63823658	A	A	63823658	3	1	276	1	0	0	0	0	1	0	0	0	15936	1058	37	1	288	1	THOC7	3	63823658	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1566563	63823658	134198772	372	50261											
ATXN7	6314	broad.mit.edu	37	chr3	63976037	63976037	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattattcaggtcatcatcCtcagccagcatctgtaagtt	10	14	6	11	0	6	0	5	0	1	0	7	0	7	0	2	1	2	3	2	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:63976037C>T	uc003dlw.3	+	10	2100	c.1547C>T	c.(1546-1548)CCT>CTT	p.P516L	ATXN7_uc003dlv.2_Missense_Mutation_p.P516L|ATXN7_uc010hnv.2_Missense_Mutation_p.P516L|ATXN7_uc011bfn.1_Missense_Mutation_p.P371L	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	516					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		GGTCATCATCCTCAGCCAGCA	0.572													9	31					0	0	0	0	T	63976037	T	T	63976037	3	4	276	1	0	0	0	0	1	0	0	0	1217	681	24	4	1645	4	ATXN7	3	63976037	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	152379	63976037	134046393	373	50262											
ADAMTS9	56999	broad.mit.edu	37	chr3	64587787	64587788	+	Missense_Mutation	DNP	GG	AA	AA																															acagtcctggtcagtttctgGgatataatcctggtcacact																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:64587787_64587788GG>AA	uc003dmg.2	-	26	3881_3882	c.3849_3850CC>TT	c.(3847-3852)ATCCCA>ATTTCA	p.P1284S	ADAMTS9_uc011bfo.1_Missense_Mutation_p.P1256S|ADAMTS9_uc003dmh.1_Missense_Mutation_p.P1113S|ADAMTS9_uc011bfp.1_Missense_Mutation_p.P195S	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1284	TSP type-1 8.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TCAGTTTCTGGGATATAATCCT	0.545													25	69					0	0	0	0	AA	64587788	AA	AA	64587787	3	1	276	1	0	0	0	0	1	0	0	0	273	1232	43	4	2013	4	ADAMTS9	3	64587787	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	611750	64587787	133434643	374	50263											
CNTN3	5067	broad.mit.edu	37	chr3	74418486	74418486	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taattttgctggaaaatggcAgcccatcacttcttctccaa	11	13	6	11	0	3	0	1	0	2	0	4	1	3	1	2	2	2	2	2	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:74418486A>C	uc003dpm.1	-	7	880	c.800T>G	c.(799-801)CTG>CGG	p.L267R		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	267	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GGAAAATGGCAGCCCATCACT	0.403													19	38					0	0	0	0	C	74418486	C	C	74418486	3	2	276	1	0	0	0	0	1	0	0	0	3657	188	7	5	2350	5	CNTN3	3	74418486	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	9830699	74418486	123603944	375	50264											
NSUN3	63899	broad.mit.edu	37	chr3	93803120	93803120	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gttaccttagcagaactccgGgccgaatcccttcagaaaga	12	8	9	12	2	1	3	1	0	0	3	3	4	3	3	4	1	3	2	4	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:93803120G>A	uc003drl.1	+	3	408	c.292G>A	c.(292-294)GGC>AGC	p.G98S		NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	NOL1/NOP2/Sun domain family, member 3	98							methyltransferase activity			skin(1)	1						CAGAACTCCGGGCCGAATCCC	0.423													12	55					0	0	0	0	A	93803120	A	A	93803120	3	1	276	1	0	0	0	0	1	0	0	0	10733	1232	43	4	302	4	NSUN3	3	93803120	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	19384634	93803120	104219310	376	50265											
OR5H15	403274	broad.mit.edu	37	chr3	97887665	97887665	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atatctcatcaccatcatggGgaatcttggtctgattgctg	9	14	9	9	0	5	1	3	1	3	0	6	2	5	2	1	3	1	1	1	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:97887665G>A	uc011bgu.1	+	1	122	c.122G>A	c.(121-123)GGG>GAG	p.G41E		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ACCATCATGGGGAATCTTGGT	0.408													87	145					0	0	0	0	A	97887665	A	A	97887665	3	1	276	1	0	0	0	0	1	0	0	0	11215	1232	43	4	124	4	OR5H15	3	97887665	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4084545	97887665	100134765	377	50266											
OR5K1	26339	broad.mit.edu	37	chr3	98188840	98188840	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcatgatgtccaagaaactCtgcattcagatgaccacagg	14	9	8	10	0	3	4	2	2	1	2	4	4	4	4	2	1	2	1	2	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:98188840C>T	uc003dsm.2	+	1	420	c.420C>T	c.(418-420)CTC>CTT	p.L140L		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						CCAAGAAACTCTGCATTCAGA	0.468													20	107					0	0	0	0	T	98188840	T	T	98188840	2	4	276	1	0	0	0	0	0	0	0	1	11220	900	32	2		2	OR5K1	3	98188840	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	301175	98188840	99833590	378	50267											
IMPG2	50939	broad.mit.edu	37	chr3	100995507	100995507	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aatgaagacacaaaagtataCctcccaatgttgaagtatca	18	9	6	8	0	1	3	1	2	0	1	2	3	2	3	2	0	1	3	2	0	9	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:100995507C>T	uc003duq.1	-	5	786	c.583_splice	c.e5+1	p.D195_splice	IMPG2_uc011bhe.1_Splice_Site_p.D58_splice	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2						visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CAAAAGTATACCTCCCAATGT	0.318													20	45					0	0	0	0	T	100995507	T	T	100995507	5	4	276	1	0	0	0	0	0	0	1	0	7768	521	18	4	3201	4	IMPG2	3	100995507	Splice_Site	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2806667	100995507	97026923	379	50268											
CD96	10225	broad.mit.edu	37	chr3	111261150	111261150	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcatccagatacattttGtcaagggtaagacttccagt	13	12	7	9	0	2	2	2	0	0	2	4	2	4	2	2	1	1	1	2	1	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:111261150G>T	uc003dxw.2	+	1	225	c.55G>T	c.(55-57)GTC>TTC	p.V19F	CD96_uc003dxv.2_Missense_Mutation_p.V19F|CD96_uc003dxx.2_Missense_Mutation_p.V19F|CD96_uc010hpy.1_Missense_Mutation_p.V19F	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	19					cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						GATACATTTTGTCAAGGGTAA	0.438									Opitz_Trigonocephaly_syndrome				23	35					1.96895e-08	2.00774e-08	1	0	T	111261150	T	T	111261150	3	4	276	1	0	0	0	0	1	0	0	0	3063	1377	48	4	57	4	CD96	3	111261150	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	10265643	111261150	86761280	380	50269											
BOC	91653	broad.mit.edu	37	chr3	112991948	112991948	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaccatggagctatcccagCtggtcatcccctggggccag	7	8	11	15	0	2	0	2	0	0	0	4	1	4	1	5	4	2	2	5	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:112991948C>T	uc003dzx.2	+	8	1615	c.994C>T	c.(994-996)CTG>TTG	p.L332L	BOC_uc003dzy.2_Silent_p.L332L|BOC_uc003dzz.2_Silent_p.L332L|BOC_uc003eab.2_Silent_p.L33L	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	332	Ig-like C2-type 4.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GCTATCCCAGCTGGTCATCCC	0.632													22	61					0	0	0	0	T	112991948	T	T	112991948	2	4	276	1	0	0	0	0	0	0	0	1	1484	796	28	4		4	BOC	3	112991948	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1730798	112991948	85030482	381	50270											
SIDT1	54847	broad.mit.edu	37	chr3	113323756	113323756	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggttctttctgcctgcataGgaacatcatcaccattgctg	8	14	8	11	0	4	0	2	0	2	0	4	1	4	1	2	2	4	3	2	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:113323756G>A	uc003eak.2	+	14	1989	c.1338_splice	c.e14-1	p.W446_splice	SIDT1_uc011bif.1_Splice_Site|SIDT1_uc003eaj.1_Splice_Site_p.W446_splice|SIDT1_uc011big.1_Splice_Site_p.W199_splice|SIDT1_uc011bih.1_Splice_Site|SIDT1_uc011bii.1_5'Flank	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor							integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						TGCCTGCATAGGAACATCATC	0.453													19	114					0	0	0	0	A	113323756	A	A	113323756	5	1	276	1	0	0	0	0	0	0	1	0	14367	1014	35	4	1391	4	SIDT1	3	113323756	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	331808	113323756	84698674	382	50271											
DRD3	1814	broad.mit.edu	37	chr3	113858410	113858410	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtcgagtgaggatccttttCcgtctcctttgtttcagcac	5	16	9	11	2	2	1	1	1	1	0	6	3	4	2	3	1	1	2	3	1	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:113858410C>T	uc003ebd.2	-	6	1083	c.660G>A	c.(658-660)CGG>CGA	p.R220R	DRD3_uc010hqn.1_Silent_p.R220R|DRD3_uc003ebb.1_Silent_p.R220R|DRD3_uc003ebc.1_Silent_p.R220R	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	220	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GGATCCTTTTCCGTCTCCTTT	0.507													63	115					0	0	0	0	T	113858410	T	T	113858410	2	4	276	1	0	0	0	0	0	0	0	1	4780	842	30	2		2	DRD3	3	113858410	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	534654	113858410	84164020	383	50272											
PLA1A	51365	broad.mit.edu	37	chr3	119325781	119325781	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctccaaaactctgggttCaatgccactctgggaaccaa	12	8	8	13	0	3	0	1	0	2	0	4	2	4	1	4	2	3	1	4	2	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:119325781C>A	uc003ecu.2	+	2	273	c.234C>A	c.(232-234)TTC>TTA	p.F78L	PLA1A_uc003ecv.2_Missense_Mutation_p.F78L|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_Intron	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	78					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ACTCTGGGTTCAATGCCACTC	0.443													39	153					8.48111e-28	8.84015e-28	1	0	A	119325781	A	A	119325781	3	1	276	1	0	0	0	0	1	0	0	0	12043	825	29	2	240	2	PLA1A	3	119325781	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5467371	119325781	78696649	384	50273											
POLQ	10721	broad.mit.edu	37	chr3	121151809	121151809	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcatataggagttcatcatGgagttgaaggatgaagaagc	14	11	12	4	0	3	3	3	2	0	1	3	6	3	6	0	3	1	2	0	3	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:121151809G>A	uc003eee.3	-	29	7744	c.7615C>T	c.(7615-7617)CAT>TAT	p.H2539Y	POLQ_uc003eed.2_Missense_Mutation_p.H1711Y	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2539					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AGTTCATCATGGAGTTGAAGG	0.413								DNA_polymerases_(catalytic_subunits)					28	28					0	0	0	0	A	121151809	A	A	121151809	3	1	276	1	0	0	0	0	1	0	0	0	12263	1348	47	4	165	4	POLQ	3	121151809	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1826028	121151809	76870621	385	50274											
POLQ	10721	broad.mit.edu	37	chr3	121207527	121207527	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccaatagtattggagaatgGaaaatcgggctttctggagt	12	12	12	5	1	1	1	0	0	1	1	3	4	2	3	1	4	0	2	1	4	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:121207527G>A	uc003eee.3	-	16	4380	c.4251C>T	c.(4249-4251)TTC>TTT	p.F1417F	POLQ_uc003eed.2_Silent_p.F589F	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1417					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TTGGAGAATGGAAAATCGGGC	0.343								DNA_polymerases_(catalytic_subunits)					12	62					0	0	0	0	A	121207527	A	A	121207527	2	1	276	1	0	0	0	0	0	0	0	1	12263	1165	41	2		2	POLQ	3	121207527	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	55718	121207527	76814903	386	50275											
CD86	942	broad.mit.edu	37	chr3	121828255	121828255	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcaactcttataaatgtGgtgagtgagtccttgtcctc	8	14	9	10	1	1	2	0	2	1	0	5	2	3	2	2	1	1	1	2	1	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:121828255G>A	uc003eet.2	+	5	963	c.847G>A	c.(847-849)GGA>AGA	p.G283R	CD86_uc011bjo.1_Missense_Mutation_p.G201R|CD86_uc011bjp.1_Missense_Mutation_p.G171R|CD86_uc003eeu.2_Missense_Mutation_p.G277R	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	283	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	TTATAAATGTGGTGAGTGAGT	0.473													27	129					0	0	0	0	A	121828255	A	A	121828255	3	1	276	1	0	0	0	0	1	0	0	0	3058	1362	47	4	865	4	CD86	3	121828255	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	620728	121828255	76194175	387	50276											
CASR	846	broad.mit.edu	37	chr3	122003885	122003886	+	Missense_Mutation	DNP	GG	AA	AA																															gacttagatctgaccgtccaGgaaacaggtctgcaaggacc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:122003885_122003886GG>AA	uc003eev.3	+	7	3456_3457	c.3084_3085GG>AA	c.(3082-3087)CAGGAA>CAAAAA	p.E1029K	CASR_uc003eew.3_Missense_Mutation_p.E1039K	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	1029	Cytoplasmic (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGACCGTCCAGGAAACAGGTCT	0.584													9	59					0	0	0	0	AA	122003886	AA	AA	122003885	3	1	276	1	0	0	0	0	1	0	0	0	2694	991	35	4	3136	4	CASR	3	122003885	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	175630	122003885	76018545	388	50277											
ALDH1L1	10840	broad.mit.edu	37	chr3	125855667	125855667	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccctcggcatccacgaactcCcccccaatgaagagctggtg	9	6	9	17	2	0	2	0	1	0	1	3	3	2	2	5	2	2	2	5	2	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:125855667C>T	uc003eim.1	-	11	1474	c.1284G>A	c.(1282-1284)GGG>GGA	p.G428G	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Silent_p.G327G|ALDH1L1_uc003eio.2_Silent_p.G130G|ALDH1L1_uc010hsf.1_Silent_p.G454G	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	428	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CCACGAACTCCCCCCCAATGA	0.592													4	16					0	0	0	0	T	125855667	T	T	125855667	2	4	276	1	0	0	0	0	0	0	0	1	494	610	22	4		4	ALDH1L1	3	125855667	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3851782	125855667	72166763	389	50278											
H1FOO	132243	broad.mit.edu	37	chr3	129267879	129267879	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagaagaaaatccagcccagGaagatggcccccgcgacggc	14	2	12	13	3	0	3	0	0	0	3	1	5	1	4	4	3	1	0	4	3	5	0	rs145471008		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:129267879G>A	uc003emu.2	+	3	419	c.414G>A	c.(412-414)AGG>AGA	p.R138R	H1FOO_uc003emv.2_5'UTR	NM_153833	NP_722575	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	138					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding	p.R138R(1)		skin(1)	1						TCCAGCCCAGGAAGATGGCCC	0.647													3	19					0	0	0	0	A	129267879	A	A	129267879	2	1	276	1	0	0	0	0	0	0	0	1	6961	1165	41	2		2	H1FOO	3	129267879	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3412212	129267879	68754551	390	50279											
PLXND1	23129	broad.mit.edu	37	chr3	129292537	129292537	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccggcccaggttccttcCtcggatggtcagcagggtcc	4	8	13	16	3	1	0	1	0	0	0	5	1	4	1	6	5	1	2	6	5	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:129292537C>T	uc003emx.2	-	13	2837	c.2737G>A	c.(2737-2739)GGA>AGA	p.G913R		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	913	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						AGGTTCCTTCCTCGGATGGTC	0.657													7	20					0	0	0	0	T	129292537	T	T	129292537	3	4	276	1	0	0	0	0	1	0	0	0	12182	690	24	4	3136	4	PLXND1	3	129292537	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	24658	129292537	68729893	391	50280											
PLXND1	23129	broad.mit.edu	37	chr3	129324699	129324699	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgatcttgaggatgttgtCgtcggaggggttgaggtcga	6	13	17	5	3	1	3	0	3	1	0	4	6	1	5	0	5	0	2	0	5	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:129324699C>T	uc003emx.2	-	1	884	c.784G>A	c.(784-786)GAC>AAC	p.D262N		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	262	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						AGGATGTTGTCGTCGGAGGGG	0.662													3	18					0	0	0	0	T	129324699	T	T	129324699	3	4	276	1	0	0	0	0	1	0	0	0	12182	884	31	1	5137	1	PLXND1	3	129324699	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	32162	129324699	68697731	392	50281											
TRH	7200	broad.mit.edu	37	chr3	129695865	129695865	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaggaagagagagaggaaGacctgatgcctgaaaaacgc	17	3	15	6	1	0	5	0	2	0	3	0	10	0	8	2	3	2	0	2	3	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:129695865G>A	uc003enc.2	+	3	1096	c.535G>A	c.(535-537)GAC>AAC	p.D179N		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	179					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						gagagaggaagaCCTGATGCC	0.532													17	30					0	0	0	0	A	129695865	A	A	129695865	3	1	276	1	0	0	0	0	1	0	0	0	16545	942	33	2	541	2	TRH	3	129695865	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	371166	129695865	68326565	393	50282											
COL6A6	131873	broad.mit.edu	37	chr3	130313125	130313125	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgatttgtattaactttagGgaagcccagggaagagaggg	12	10	14	5	0	0	2	0	1	0	1	0	5	0	4	1	3	2	1	1	3	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:130313125G>A	uc010htl.2	+	17	4502	c.4471G>A	c.(4471-4473)GGA>AGA	p.G1491R	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1491	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TTAACTTTAGGGAAGCCCAGG	0.428													10	64					0	0	0	0	A	130313125	A	A	130313125	3	1	276	1	0	0	0	0	1	0	0	0	3718	1246	43	4	4537	4	COL6A6	3	130313125	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	617260	130313125	67709305	394	50283											
PIK3R4	30849	broad.mit.edu	37	chr3	130452399	130452399	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aataaactcttaccagcataGgctagtctaacgatagtagc	15	10	7	9	1	2	0	0	0	2	0	2	1	2	0	1	1	5	3	1	1	9	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:130452399G>A	uc003enj.2	-	4	2024	c.1443C>T	c.(1441-1443)GCC>GCT	p.A481A		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	481	HEAT 2.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TACCAGCATAGGCTAGTCTAA	0.353													8	46					0	0	0	0	A	130452399	A	A	130452399	2	1	276	1	0	0	0	0	0	0	0	1	11976	987	35	4		4	PIK3R4	3	130452399	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	139274	130452399	67570031	395	50284											
PCCB	5096	broad.mit.edu	37	chr3	136046022	136046022	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcacaggaatacgggggcatCatccggcatggtgccaagct	10	6	14	11	2	1	0	1	0	0	0	2	1	2	1	2	5	3	4	2	5	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:136046022C>T	uc003eqy.1	+	12	1275	c.1224C>T	c.(1222-1224)ATC>ATT	p.I408I	PCCB_uc003eqz.1_Silent_p.I408I|PCCB_uc011bmc.1_Silent_p.I428I|PCCB_uc011bmd.1_3'UTR	NM_000532	NP_000523	P05166	PCCB_HUMAN	propionyl Coenzyme A carboxylase, beta	408	Carboxyltransferase.		Missing (in PA-2).		fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity				0					Biotin(DB00121)|L-Valine(DB00161)	ACGGGGGCATCATCCGGCATG	0.522													33	40					0	0	0	0	T	136046022	T	T	136046022	2	4	276	1	0	0	0	0	0	0	0	1	11559	816	29	2		2	PCCB	3	136046022	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5593623	136046022	61976408	396	50285											
IL20RB	53833	broad.mit.edu	37	chr3	136708318	136708318	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgggatggagatcaccaaaGatggcttccacctggttatt	10	11	11	9	0	1	2	1	0	0	2	2	4	2	3	3	4	0	2	3	4	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:136708318G>A	uc003eri.1	+	4	691	c.442G>A	c.(442-444)GAT>AAT	p.D148N	IL20RB_uc003erj.1_RNA|IL20RB_uc010hud.1_Missense_Mutation_p.D6N	NM_144717	NP_653318	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta precursor	148	Extracellular (Potential).|Fibronectin type-III 2.					integral to membrane	receptor activity			ovary(1)	1						GATCACCAAAGATGGCTTCCA	0.567													9	55					0	0	0	0	A	136708318	A	A	136708318	3	1	276	1	0	0	0	0	1	0	0	0	7708	942	33	2	456	2	IL20RB	3	136708318	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	662296	136708318	61314112	397	50286											
GRK7	131890	broad.mit.edu	37	chr3	141499323	141499323	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagatggctctcttggaaaaGgaaatcttggagaaggtcag	14	9	13	5	0	3	2	1	0	2	2	4	5	3	4	0	5	0	1	0	5	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:141499323G>A	uc011bnd.1	+	2	804	c.720G>A	c.(718-720)AAG>AAA	p.K240K		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	240	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						TCTTGGAAAAGGAAATCTTGG	0.498													19	76					0	0	0	0	A	141499323	A	A	141499323	2	1	276	1	0	0	0	0	0	0	0	1	6833	991	35	4		4	GRK7	3	141499323	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4791005	141499323	56523107	398	50287											
XRN1	54464	broad.mit.edu	37	chr3	142048324	142048324	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggttgtggcattccaacaagGgaacaaattcgagaaagttc	14	9	11	7	1	0	1	0	0	0	1	3	3	1	2	1	3	2	3	1	3	5	4	rs139447998		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:142048324G>A	uc003eus.2	-	37	4420	c.4353C>T	c.(4351-4353)TCC>TCT	p.S1451S	XRN1_uc010huu.2_Silent_p.S918S|XRN1_uc003eut.2_Silent_p.S1451S|XRN1_uc003euu.2_Silent_p.S1452S	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1451					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						TTCCAACAAGGGAACAAATTC	0.388													12	31					0	0	0	0	A	142048324	A	A	142048324	2	1	276	1	0	0	0	0	0	0	0	1	17527	1219	43	4		4	XRN1	3	142048324	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	549001	142048324	55974106	399	50288											
SLC9A9	285195	broad.mit.edu	37	chr3	143371183	143371183	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggtcgacgtgcagttcatgGaaaatggccagcactgtcac	10	8	13	10	2	2	0	2	0	0	0	3	2	2	1	1	3	2	3	1	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:143371183G>A	uc003evn.2	-	6	851	c.669C>T	c.(667-669)TTC>TTT	p.F223F	SLC9A9_uc011bnk.1_Silent_p.F97F	NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	223	Helical; (Potential).				regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						GCAGTTCATGGAAAATGGCCA	0.473													8	21					0	0	0	0	A	143371183	A	A	143371183	2	1	276	1	0	0	0	0	0	0	0	1	14785	1165	41	2		2	SLC9A9	3	143371183	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1322859	143371183	54651247	400	50289											
TM4SF4	7104	broad.mit.edu	37	chr3	149205446	149205446	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgctgtggttggattcttggGagctggatactcgtttatca	6	16	13	6	1	2	0	1	0	1	0	3	3	2	3	0	4	3	4	0	4	2	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:149205446G>A	uc003exd.1	+	3	536	c.305G>A	c.(304-306)GGA>GAA	p.G102E		NM_004617	NP_004608	P48230	T4S4_HUMAN	transmembrane 4 superfamily member 4	102	Helical; (Potential).					integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GGATTCTTGGGAGCTGGATAC	0.478													17	58					0	0	0	0	A	149205446	A	A	149205446	3	1	276	1	0	0	0	0	1	0	0	0	16036	1174	41	2	315	2	TM4SF4	3	149205446	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5834263	149205446	48816984	401	50290											
CLRN1	7401	broad.mit.edu	37	chr3	150690369	150690369	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcattgacgagcagagctcCcgttttgcagaggacagtgg	9	8	15	9	2	0	3	0	1	0	2	1	5	1	4	1	3	3	5	1	3	0	3	rs111033434		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:150690369C>T	uc003eyk.1	-	1	418	c.127G>A	c.(127-129)GGA>AGA	p.G43R	CLRN1OS_uc011bny.1_Intron|CLRN1OS_uc003eyl.2_5'Flank	NM_174878	NP_777367	P58418	CLRN1_HUMAN	clarin 1 isoform a	43					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AGCAGAGCTCCCGTTTTGCAG	0.547													26	102					0	0	0	0	T	150690369	T	T	150690369	3	4	276	1	0	0	0	0	1	0	0	0	3572	632	22	4	637	4	CLRN1	3	150690369	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1484923	150690369	47332061	402	50291											
MED12L	116931	broad.mit.edu	37	chr3	150876480	150876480	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctttgttcatttaaggaagGaatgttagaaaaacacgaat	16	13	8	4	1	2	1	1	0	1	1	2	4	2	3	0	2	1	2	0	2	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:150876480G>A	uc003eyp.2	+	6	769	c.731G>A	c.(730-732)GGA>GAA	p.G244E	MED12L_uc011bnz.1_Missense_Mutation_p.G244E|MED12L_uc003eym.1_Missense_Mutation_p.G244E|MED12L_uc003eyn.2_Missense_Mutation_p.G244E|MED12L_uc003eyo.2_Missense_Mutation_p.G244E	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	244					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTTAAGGAAGGAATGTTAGAA	0.303													9	26					0	0	0	0	A	150876480	A	A	150876480	3	1	276	1	0	0	0	0	1	0	0	0	9482	1174	41	2	753	2	MED12L	3	150876480	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	186111	150876480	47145950	403	50292											
IGSF10	285313	broad.mit.edu	37	chr3	151155338	151155338	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttaaatggatttctaaatgtCggtcttctcagcatttccag	10	16	7	8	1	3	0	1	0	3	0	6	1	4	1	1	2	1	1	1	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:151155338C>T	uc011bod.1	-	6	7011	c.7011G>A	c.(7009-7011)CCG>CCA	p.P2337P	IGSF10_uc011bob.1_Silent_p.P364P|IGSF10_uc011boc.1_Silent_p.P316P	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2337	Ig-like C2-type 10.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTCTAAATGTCGGTCTTCTCA	0.433													41	69					0	0	0	0	T	151155338	T	T	151155338	2	4	276	1	0	0	0	0	0	0	0	1	7636	871	31	1		1	IGSF10	3	151155338	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	278858	151155338	46867092	404	50293											
VEPH1	79674	broad.mit.edu	37	chr3	157082173	157082173	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tagagccaggggtattgctcCctgcatttatcttgtcttca	7	15	9	10	0	3	1	1	0	2	1	4	1	4	1	2	2	3	3	2	2	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:157082173C>T	uc003fbj.1	-	8	1573	c.1256G>A	c.(1255-1257)GGG>GAG	p.G419E	VEPH1_uc003fbk.1_Missense_Mutation_p.G419E|VEPH1_uc010hvu.1_Missense_Mutation_p.G419E	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	419						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			GGTATTGCTCCCTGCATTTAT	0.373													14	87					0	0	0	0	T	157082173	T	T	157082173	3	4	276	1	0	0	0	0	1	0	0	0	17222	623	22	4	1273	4	VEPH1	3	157082173	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5926835	157082173	40940257	405	50294											
VEPH1	79674	broad.mit.edu	37	chr3	157099102	157099102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccagcaggagaatatggtGaaacgaatgctccatgttgg	12	9	12	8	1	0	2	0	1	0	1	2	4	2	2	2	3	3	3	2	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:157099102G>A	uc003fbj.1	-	7	1287	c.970C>T	c.(970-972)CAC>TAC	p.H324Y	VEPH1_uc003fbk.1_Missense_Mutation_p.H324Y|VEPH1_uc010hvu.1_Missense_Mutation_p.H324Y	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	324						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			AGAATATGGTGAAACGAATGC	0.473													14	67					0	0	0	0	A	157099102	A	A	157099102	3	1	276	1	0	0	0	0	1	0	0	0	17222	1290	45	2	1563	2	VEPH1	3	157099102	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	16929	157099102	40923328	406	50295											
BCHE	590	broad.mit.edu	37	chr3	165503942	165503942	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aacagacacacctgtcatttCcaagacttttggaaaaaatg	16	10	6	9	0	1	2	1	0	0	2	2	3	2	3	2	1	1	0	2	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:165503942C>A	uc003fem.3	-	3	1835	c.1675G>T	c.(1675-1677)GAA>TAA	p.E559*	BCHE_uc003fen.3_RNA	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	559					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	CCTGTCATTTCCAAGACTTTT	0.358													11	51					6.81908e-15	7.03833e-15	1	0	A	165503942	A	A	165503942	4	1	276	1	0	0	0	0	0	1	0	0	1360	864	30	2	141	2	BCHE	3	165503942	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	8404840	165503942	32518488	407	50296											
LRRIQ4	344657	broad.mit.edu	37	chr3	169540214	169540214	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgaaccagaccaagctgaggGagatctacctgaagcgaaac	15	5	11	10	1	1	5	0	3	1	2	1	7	1	5	3	1	5	1	3	1	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:169540214G>A	uc003fgb.2	+	1	505	c.505G>A	c.(505-507)GAG>AAG	p.E169K		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	169	LRR 7.										0						CAAGCTGAGGGAGATCTACCT	0.493													9	54					0	0	0	0	A	169540214	A	A	169540214	3	1	276	1	0	0	0	0	1	0	0	0	9081	1175	41	2	507	2	LRRIQ4	3	169540214	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4036272	169540214	28482216	408	50297											
PLD1	5337	broad.mit.edu	37	chr3	171443857	171443857	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agacagctggcttatatcaaGaaactctgtctgaaaagaag	16	9	9	7	0	3	4	1	1	2	3	3	4	3	4	0	1	2	2	0	1	7	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:171443857G>A	uc003fhs.2	-	7	732	c.616C>T	c.(616-618)CTT>TTT	p.L206F	PLD1_uc003fht.2_Missense_Mutation_p.L206F	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	206	PX.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	CTTATATCAAGAAACTCTGTC	0.318													16	48					0	0	0	0	A	171443857	A	A	171443857	3	1	276	1	0	0	0	0	1	0	0	0	12100	942	33	2	2692	2	PLD1	3	171443857	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1903643	171443857	26578573	409	50298											
MFN1	55669	broad.mit.edu	37	chr3	179104303	179104304	+	Nonsense_Mutation	DNP	GG	AA	AA																															tctttatgaaagactgagctGgaccacccatgccaaggagc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:179104303_179104304GG>AA	uc003fjs.2	+	16	2024_2025	c.1898_1899GG>AA	c.(1897-1899)TGG>TAA	p.W633*	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Nonsense_Mutation_p.W661*|MFN1_uc010hxc.2_Nonsense_Mutation_p.W375*	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	633	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			AGACTGAGCTGGACCACCCATG	0.401													20	62					0	0	0	0	AA	179104304	AA	AA	179104303	4	1	276	1	0	0	0	0	0	1	0	0	9576	1357	47	4	1956	4	MFN1	3	179104303	Nonsense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	7660446	179104303	18918127	410	50299											
PEX5L	51555	broad.mit.edu	37	chr3	179576913	179576913	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggtttctagaaagtaatgcGcttccccagcgatgttcttt	8	15	9	9	2	2	1	0	0	2	1	3	2	3	1	2	1	2	4	2	1	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:179576913G>A	uc003fki.1	-	8	889	c.759C>T	c.(757-759)AGC>AGT	p.S253S	PEX5L_uc011bqd.1_Silent_p.S210S|PEX5L_uc011bqe.1_Silent_p.S61S|PEX5L_uc011bqf.1_Silent_p.S145S|PEX5L_uc003fkj.1_Silent_p.S218S|PEX5L_uc010hxd.1_Silent_p.S251S|PEX5L_uc011bqg.1_Silent_p.S229S|PEX5L_uc011bqh.1_Silent_p.S194S	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	253					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			AAAGTAATGCGCTTCCCCAGC	0.368													23	80					0	0	0	0	A	179576913	A	A	179576913	2	1	276	1	0	0	0	0	0	0	0	1	11804	1078	38	1		1	PEX5L	3	179576913	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	472610	179576913	18445517	411	50300											
KLHL6	89857	broad.mit.edu	37	chr3	183217505	183217505	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggctgcgcctcagggggtcCaggcaggtcacctctgccac	5	6	14	16	2	3	0	2	0	1	0	4	0	4	0	4	5	2	2	4	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:183217505C>T	uc003flr.2	-	4	1078	c.1020G>A	c.(1018-1020)CTG>CTA	p.L340L	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Intron	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	340	Kelch 1.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			TCAGGGGGTCCAGGCAGGTCA	0.577													11	54					0	0	0	0	T	183217505	T	T	183217505	2	4	276	1	0	0	0	0	0	0	0	1	8432	581	21	4		4	KLHL6	3	183217505	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3640592	183217505	14804925	412	50301											
KLHL24	54800	broad.mit.edu	37	chr3	183368285	183368285	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gacttctcttcaggatcatcCcatgccgaaaacatactcca	12	10	5	14	1	3	0	2	0	1	0	6	3	5	1	3	1	3	0	3	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:183368285C>T	uc003flv.2	+	3	436	c.141C>T	c.(139-141)TCC>TCT	p.S47S	KLHL24_uc003flw.2_Silent_p.S47S|KLHL24_uc003flx.2_Silent_p.S47S	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	47						axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CAGGATCATCCCATGCCGAAA	0.403													21	93					0	0	0	0	T	183368285	T	T	183368285	2	4	276	1	0	0	0	0	0	0	0	1	8418	610	22	4		4	KLHL24	3	183368285	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	150780	183368285	14654145	413	50302											
YEATS2	55689	broad.mit.edu	37	chr3	183508723	183508723	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcgtcagcgccacgtccCtcgtgcctacaccaaacccc	7	6	7	21	5	1	0	1	0	0	0	4	0	2	0	7	0	4	0	7	0	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:183508723C>T	uc003fly.2	+	21	3247	c.3052C>T	c.(3052-3054)CTC>TTC	p.L1018F	YEATS2_uc003flz.2_Missense_Mutation_p.L97F	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1018					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CGCCACGTCCCTCGTGCCTAC	0.537													26	90					0	0	0	0	T	183508723	T	T	183508723	3	4	276	1	0	0	0	0	1	0	0	0	17540	681	24	4	3130	4	YEATS2	3	183508723	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	140438	183508723	14513707	414	50303											
HTR3D	200909	broad.mit.edu	37	chr3	183756374	183756374	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcccactgcgccccagaaggGaaataagggcccgggtctca	10	5	12	14	2	1	1	1	0	1	1	3	2	2	2	4	3	1	0	4	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:183756374G>A	uc011bqv.1	+	7	1097	c.1097G>A	c.(1096-1098)GGA>GAA	p.G366E	HTR3D_uc003fmj.2_Missense_Mutation_p.G191E|HTR3D_uc011bqu.1_Missense_Mutation_p.G316E|HTR3D_uc010hxp.2_Missense_Mutation_p.G145E	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	366	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCCCAGAAGGGAAATAAGGGC	0.512													3	20					0	0	0	0	A	183756374	A	A	183756374	3	1	276	1	0	0	0	0	1	0	0	0	7486	1174	41	2	1293	2	HTR3D	3	183756374	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	247651	183756374	14266056	415	50304											
CLCN2	1181	broad.mit.edu	37	chr3	184064422	184064422	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttgtcgtcgctgtcggaaGggctgccctcccgggggagg	4	9	17	11	4	0	0	0	0	0	0	4	2	1	2	2	5	1	2	2	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:184064422G>C	uc003foi.2	-	24	2793	c.2669C>G	c.(2668-2670)CCT>CGT	p.P890R	CLCN2_uc003foh.2_Missense_Mutation_p.P379R|CLCN2_uc010hya.1_Missense_Mutation_p.P873R|CLCN2_uc011brl.1_Missense_Mutation_p.P861R|CLCN2_uc011brm.1_Missense_Mutation_p.P846R	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	890	Cytoplasmic (By similarity).					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	GCTGTCGGAAGGGCTGCCCTC	0.622													6	52					0	0	0	0	C	184064422	C	C	184064422	3	2	276	1	0	0	0	0	1	0	0	0	3478	1000	35	4	31	4	CLCN2	3	184064422	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	308048	184064422	13958008	416	50305											
CLCN2	1181	broad.mit.edu	37	chr3	184071990	184071990	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgggcgacagcgttggcCaggatgacggcgatcatgac	8	7	15	11	4	2	2	1	2	1	0	2	5	2	3	1	4	1	1	1	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:184071990C>T	uc003foi.2	-	15	1744	c.1620G>A	c.(1618-1620)CTG>CTA	p.L540L	CLCN2_uc003foh.2_Silent_p.L64L|CLCN2_uc010hya.1_Silent_p.L523L|CLCN2_uc011brl.1_Silent_p.L540L|CLCN2_uc011brm.1_Silent_p.L496L	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	540	Helical; (By similarity).					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	CAGCGTTGGCCAGGATGACGG	0.612											OREG0015949	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	33					0	0	0	0	T	184071990	T	T	184071990	2	4	276	1	0	0	0	0	0	0	0	1	3478	581	21	4		4	CLCN2	3	184071990	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	7568	184071990	13950440	417	50306											
MAP3K13	9175	broad.mit.edu	37	chr3	185146818	185146818	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tatcattgggaaggcatattCcactgattacaaattgcagc	13	12	8	8	0	1	1	1	1	0	0	2	2	2	2	1	2	3	2	1	2	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:185146818C>T	uc010hyf.2	+	3	715	c.449C>T	c.(448-450)TCC>TTC	p.S150F	MAP3K13_uc011brt.1_Intron|MAP3K13_uc003fph.3_Intron|MAP3K13_uc011bru.1_Intron|MAP3K13_uc003fpi.2_Missense_Mutation_p.S150F|MAP3K13_uc010hyg.2_5'UTR	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	150					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAGGCATATTCCACTGATTAC	0.443													9	41					0	0	0	0	T	185146818	T	T	185146818	3	4	276	1	0	0	0	0	1	0	0	0	9300	855	30	2	451	2	MAP3K13	3	185146818	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1074828	185146818	12875612	418	50307											
TRA2B	6434	broad.mit.edu	37	chr3	185643253	185643253	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccagtttttcatcttaccCgattcccaacatgacgcctg	10	12	5	14	2	2	1	1	1	1	0	3	2	3	1	4	0	3	1	4	0	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:185643253C>G	uc003fpv.2	-	3	608	c.332G>C	c.(331-333)CGG>CCG	p.R111P	TRA2B_uc003fpt.2_5'Flank|TRA2B_uc003fpu.2_RNA|TRA2B_uc010hym.2_Missense_Mutation_p.R11P|TRA2B_uc003fpw.2_Missense_Mutation_p.R111P	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	111	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2						TCATCTTACCCGATTCCCAAC	0.443													16	59					0	0	0	0	G	185643253	G	G	185643253	3	3	276	1	0	0	0	0	1	0	0	0	16501	666	23	3	562	3	TRA2B	3	185643253	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	496435	185643253	12379177	419	50308											
CLDN16	10686	broad.mit.edu	37	chr3	190122651	190122651	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttgactgcgtgaaattcctCcctgatgagccgtacattaa	10	12	8	11	2	0	4	0	4	0	0	2	4	2	4	3	0	3	1	3	0	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:190122651C>T	uc003fsi.2	+	3	596	c.528C>T	c.(526-528)CTC>CTT	p.L176L	CLDN16_uc010hze.2_Intron	NM_006580	NP_006571	Q9Y5I7	CLD16_HUMAN	claudin 16	176	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		TGAAATTCCTCCCTGATGAGC	0.502													19	60					0	0	0	0	T	190122651	T	T	190122651	2	4	276	1	0	0	0	0	0	0	0	1	3492	842	30	2		2	CLDN16	3	190122651	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4479398	190122651	7899779	420	50309											
IL1RAP	3556	broad.mit.edu	37	chr3	190363561	190363562	+	Missense_Mutation	DNP	CC	TT	TT																															gaatttgtattactgaccctCcgtggagttttggagaatga																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:190363561_190363562CC>TT	uc003fsm.1	+	11	1481_1482	c.1275_1276CC>TT	c.(1273-1278)CTCCGT>CTTTGT	p.R426C	IL1RAP_uc010hzg.1_Missense_Mutation_p.R426C|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Missense_Mutation_p.R426C|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Missense_Mutation_p.R426C	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	426	Cytoplasmic (Potential).|TIR.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		TACTGACCCTCCGTGGAGTTTT	0.406													29	49					0	0	0	0	TT	190363562	TT	TT	190363561	3	4	276	1	0	0	0	0	1	0	0	0	7699	842	30	2	1329	2	IL1RAP	3	190363561	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	240910	190363561	7658869	421	50310											
OSTN	344901	broad.mit.edu	37	chr3	190930354	190930354	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agattggcaagtgcacatttCatcctggctgtgacactgac	10	11	10	10	0	1	3	1	2	0	1	2	3	2	3	1	2	1	3	1	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:190930354C>T	uc011bsn.1	+	1	33	c.33C>T	c.(31-33)TTC>TTT	p.F11F		NM_198184	NP_937827	P61366	OSTN_HUMAN	osteocrin precursor	11					cell differentiation|multicellular organismal development|ossification		hormone activity			pancreas(1)|skin(1)	2	all_cancers(143;6.79e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000254)		GTGCACATTTCATCCTGGCTG	0.398													17	21					0	0	0	0	T	190930354	T	T	190930354	2	4	276	1	0	0	0	0	0	0	0	1	11353	825	29	2		2	OSTN	3	190930354	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	566793	190930354	7092076	422	50311											
HRASLS	57110	broad.mit.edu	37	chr3	192980899	192980899	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atgaaacgtacccccctctcCctgtggaagaaatcataaag	14	8	7	12	1	2	2	1	1	1	1	3	3	2	3	4	1	2	1	4	1	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:192980899C>T	uc003fta.2	+	3	685	c.280C>T	c.(280-282)CCT>TCT	p.P94S		NM_020386	NP_065119	Q9HDD0	HRSL1_HUMAN	HRAS-like suppressor	94											0	all_cancers(143;9.1e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000159)		CCCCCCTCTCCCTGTGGAAGA	0.428													21	90					0	0	0	0	T	192980899	T	T	192980899	3	4	276	1	0	0	0	0	1	0	0	0	7388	623	22	4	286	4	HRASLS	3	192980899	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2050545	192980899	5041531	423	50312											
ATP13A4	84239	broad.mit.edu	37	chr3	193174805	193174805	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agacctgtctcaggttggcaAaagctggccaccctctctgg	8	9	11	13	0	2	1	1	0	2	1	4	1	2	1	3	4	1	3	3	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:193174805A>T	uc003ftd.2	-	16	2007	c.1899T>A	c.(1897-1899)TTT>TTA	p.F633L	ATP13A4_uc003fte.1_Missense_Mutation_p.F633L|ATP13A4_uc011bsr.1_Missense_Mutation_p.F104L|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	633	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CAGGTTGGCAAAAGCTGGCCA	0.368													8	23					0	0	0	0	T	193174805	T	T	193174805	3	4	276	1	0	0	0	0	1	0	0	0	1128	11	1	5	1751	5	ATP13A4	3	193174805	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	193906	193174805	4847625	424	50313											
LSG1	55341	broad.mit.edu	37	chr3	194390864	194390864	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attgagttcacttgtgtgcaActatgaaaaaacacagggtg	14	11	10	6	0	1	2	1	2	0	0	1	2	1	2	0	1	3	2	0	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:194390864A>G	uc003fui.2	-	2	415	c.100T>C	c.(100-102)TTG>CTG	p.L34L		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	34					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		CTTGTGTGCAACTATGAAAAA	0.433													22	64					0	0	0	0	G	194390864	G	G	194390864	2	3	276	1	0	0	0	0	0	0	0	1	9099	57	2	5		5	LSG1	3	194390864	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1216059	194390864	3631566	425	50314											
MUC4	4585	broad.mit.edu	37	chr3	195516890	195516890	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccagctgtccctgtagatgGatttcctgtgacaagcctag	8	11	11	11	0	0	2	0	1	0	1	2	3	2	3	4	1	2	2	4	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:195516890G>A	uc011bto.1	-	2	2021	c.1561C>T	c.(1561-1563)CCA>TCA	p.P521S	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.P403S	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	526					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CCTGTAGATGGATTTCCTGTG	0.532													25	79					0	0	0	0	A	195516890	A	A	195516890	3	1	276	1	0	0	0	0	1	0	0	0	10031	1174	41	2		2	MUC4	3	195516890	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1126026	195516890	2505540	426	50315											
KIAA0226	9711	broad.mit.edu	37	chr3	197427593	197427593	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctgagaagctggacctgcgGaggacactggacagctggct	9	7	15	10	1	1	1	0	1	1	1	1	6	1	5	1	5	3	3	1	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:197427593G>A	uc003fyc.2	-	7	1335	c.1152C>T	c.(1150-1152)CTC>CTT	p.L384L	KIAA0226_uc003fyd.3_Silent_p.L324L|KIAA0226_uc003fye.1_Silent_p.L91L|KIAA0226_uc003fyf.2_Silent_p.L217L|KIAA0226_uc003fyg.2_Silent_p.L377L	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	384	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		TGGACCTGCGGAGGACACTGG	0.582													13	59					0	0	0	0	A	197427593	A	A	197427593	2	1	276	1	0	0	0	0	0	0	0	1	8201	1161	41	2		2	KIAA0226	3	197427593	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1910703	197427593	594837	427	50316											
KIAA0226	9711	broad.mit.edu	37	chr3	197432014	197432014	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agccaccggatgtctttcacGaactgccagtaatccgtctg	9	10	9	13	3	3	0	1	0	2	0	4	2	4	1	4	1	3	1	4	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr3:197432014G>A	uc003fyc.2	-	3	435	c.252C>T	c.(250-252)TTC>TTT	p.F84F	KIAA0226_uc003fyd.3_Silent_p.F24F|KIAA0226_uc003fyf.2_5'UTR|KIAA0226_uc003fyg.2_Silent_p.F77F	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	84	RUN.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		TGTCTTTCACGAACTGCCAGT	0.562													6	31					0	0	0	0	A	197432014	A	A	197432014	2	1	276	1	0	0	0	0	0	0	0	1	8201	1049	37	1		1	KIAA0226	3	197432014	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4421	197432014	590416	428	50317											
DGKQ	1609	broad.mit.edu	37	chr4	961572	961572	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccacggcagcgctcccgtcgGcgccgtcgcccccctcgcct	2	5	11	23	8	0	0	0	0	0	0	4	0	1	0	7	2	1	2	7	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:961572G>A	uc003gbw.2	-	7	904	c.830C>T	c.(829-831)GCC>GTC	p.A277V	DGKQ_uc010ibn.2_Missense_Mutation_p.A277V	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	277					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GCTCCCGTCGGCGCCGTCGCC	0.746													3	11					0	0	0	0	A	961572	A	A	961572	3	1	276	1	0	0	0	0	1	0	0	0	4495	1203	42	4	2066	4	DGKQ	4	961572	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08		961572	190192704	429	50318											
HTT	3064	broad.mit.edu	37	chr4	3230704	3230704	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagctcagccaggaggaccCcggccatcctgatcagtgag	9	5	12	15	1	2	2	2	2	0	0	3	4	3	4	6	3	2	1	6	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:3230704C>T	uc011bvq.1	+	60	8228	c.8083C>T	c.(8083-8085)CCG>TCG	p.P2695S		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2693					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CAGGAGGACCCCGGCCATCCT	0.502													10	18					0	0	0	0	T	3230704	T	T	3230704	3	4	276	1	0	0	0	0	1	0	0	0	7496	623	22	4	8311	4	HTT	4	3230704	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2269132	3230704	187923572	430	50319											
DRD5	1816	broad.mit.edu	37	chr4	9784209	9784209	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	actggcacagggaccaggcgGcctcttggggcgggctggac	6	5	18	12	2	1	0	0	0	1	0	1	2	1	2	2	8	0	2	2	8	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:9784209G>A	uc003gmb.3	+	1	952	c.556G>A	c.(556-558)GCC>ACC	p.A186T		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	186	Extracellular (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GGACCAGGCGGCCTCTTGGGG	0.617													13	40					0	0	0	0	A	9784209	A	A	9784209	3	1	276	1	0	0	0	0	1	0	0	0	4782	1203	42	4	558	4	DRD5	4	9784209	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6553505	9784209	181370067	431	50320											
CC2D2A	57545	broad.mit.edu	37	chr4	15572023	15572023	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcccacccttcctttaggaTgaccgtgaaagaggaagtgg	10	10	11	10	1	0	3	0	2	0	1	2	5	2	5	4	3	0	0	4	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:15572023T>A	uc010idv.2	+	29	3743	c.3498T>A	c.(3496-3498)GAT>GAA	p.D1166E	CC2D2A_uc003gnx.2_Missense_Mutation_p.D1117E|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	1166	C2.				cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						TCCTTTAGGATGACCGTGAAA	0.338													3	10					0	0	0	0	A	15572023	A	A	15572023	3	1	276	1	0	0	0	0	1	0	0	0	2740	1461	51	5	3807	5	CC2D2A	4	15572023	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	5787814	15572023	175582253	432	50321											
PPARGC1A	10891	broad.mit.edu	37	chr4	23815563	23815563	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagtttatcactttcatcttCgctgtcatcaaacaggccat	10	14	5	12	1	5	0	4	0	1	0	6	0	5	0	1	1	1	2	1	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:23815563C>T	uc003gqs.2	-	8	1663	c.1543G>A	c.(1543-1545)GAA>AAA	p.E515K	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	515					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				CTTTCATCTTCGCTGTCATCA	0.413													21	46					0	0	0	0	T	23815563	T	T	23815563	3	4	276	1	0	0	0	0	1	0	0	0	12355	893	31	1	877	1	PPARGC1A	4	23815563	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	8243540	23815563	167338713	433	50322											
SLC34A2	10568	broad.mit.edu	37	chr4	25665876	25665876	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccaagggattgggagattGattttacttctcggatttct	8	17	10	6	1	2	2	0	1	2	1	4	5	3	4	1	3	1	0	1	3	2	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:25665876G>A	uc003grr.2	+	4	384	c.303G>A	c.(301-303)TTG>TTA	p.L101L	SLC34A2_uc003grs.2_Silent_p.L100L|SLC34A2_uc010iev.2_Silent_p.L100L	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	101	Helical; Name=M1; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				TTGGGAGATTGATTTTACTTC	0.478													14	60					0	0	0	0	A	25665876	A	A	25665876	2	1	276	1	0	0	0	0	0	0	0	1	14632	1281	45	2		2	SLC34A2	4	25665876	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1850313	25665876	165488400	434	50323											
CCKAR	886	broad.mit.edu	37	chr4	26483501	26483501	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggatgaaggaaatgggggttCctgagaggcggcgctctgcg	8	7	19	7	3	1	2	0	2	1	1	2	5	2	4	1	6	1	2	1	6	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:26483501C>T	uc003gse.1	-	5	1199	c.1046G>A	c.(1045-1047)GGA>GAA	p.G349E		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	349	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	AATGGGGGTTCCTGAGAGGCG	0.597													19	61					0	0	0	0	T	26483501	T	T	26483501	3	4	276	1	0	0	0	0	1	0	0	0	2893	855	30	2	244	2	CCKAR	4	26483501	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	817625	26483501	164670775	435	50324											
TBC1D1	23216	broad.mit.edu	37	chr4	38126639	38126639	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagtggctttaagtctgttgGgaagccataagcccttgatt	10	13	11	7	0	1	1	0	1	1	0	1	2	1	2	2	2	2	2	2	2	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:38126639G>A	uc003gtb.2	+	18	3362	c.3019G>A	c.(3019-3021)GGA>AGA	p.G1007R	TBC1D1_uc011byd.1_Intron|TBC1D1_uc010ifd.2_Missense_Mutation_p.G794R|TBC1D1_uc003gtd.2_Missense_Mutation_p.G19R	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	1007						nucleus	Rab GTPase activator activity			ovary(1)	1						AAGTCTGTTGGGAAGCCATAA	0.393													11	54					0	0	0	0	A	38126639	A	A	38126639	3	1	276	1	0	0	0	0	1	0	0	0	15663	1233	43	4	3085	4	TBC1D1	4	38126639	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	11643138	38126639	153027637	436	50325											
CHRNA9	55584	broad.mit.edu	37	chr4	40351346	40351346	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccggagaaaaggtctccctGggagtgaccatcctgttggc	8	9	13	11	1	1	2	0	1	1	1	4	4	3	3	4	4	0	1	4	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:40351346G>T	uc003gva.1	+	4	829	c.813G>T	c.(811-813)CTG>CTT	p.L271L		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	271	Helical; (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	AGGTCTCCCTGGGAGTGACCA	0.507													43	163					1.52319e-26	1.58702e-26	1	0	T	40351346	T	T	40351346	2	4	276	1	0	0	0	0	0	0	0	1	3404	1335	47	4		4	CHRNA9	4	40351346	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2224707	40351346	150802930	437	50326											
KCTD8	386617	broad.mit.edu	37	chr4	44176945	44176945	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttagcttctcacagactttCtttttggacagatttgtttc	7	19	6	9	0	2	2	1	0	2	2	4	3	2	3	0	1	1	2	0	1	1	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:44176945C>T	uc003gwu.2	-	2	1568	c.1284G>A	c.(1282-1284)AAG>AAA	p.K428K		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	428						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						CACAGACTTTCTTTTTGGACA	0.418										HNSCC(17;0.042)			43	183					0	0	0	0	T	44176945	T	T	44176945	2	4	276	1	0	0	0	0	0	0	0	1	8154	912	32	2		2	KCTD8	4	44176945	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3825599	44176945	146977331	438	50327											
FRYL	285527	broad.mit.edu	37	chr4	48542476	48542476	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctgaggtaaaacccttaagGaagagctgctgaagtcctgg	12	8	13	8	0	0	3	0	2	0	1	1	4	1	4	2	3	3	4	2	3	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:48542476G>A	uc003gyh.1	-	46	6794	c.6189C>T	c.(6187-6189)TTC>TTT	p.F2063F	FRYL_uc003gyg.1_Silent_p.F759F|FRYL_uc003gyi.1_Silent_p.F951F|FRYL_uc003gyj.1_Silent_p.F358F	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2063					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AACCCTTAAGGAAGAGCTGCT	0.398													21	89					0	0	0	0	A	48542476	A	A	48542476	2	1	276	1	0	0	0	0	0	0	0	1	6098	1165	41	2		2	FRYL	4	48542476	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4365531	48542476	142611800	439	50328											
SPATA18	132671	broad.mit.edu	37	chr4	52938270	52938270	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ataagaaacagctccgaaacCtgaaggaggagatagctgtt	16	7	11	7	1	0	3	0	1	0	2	1	6	1	4	2	2	4	3	2	2	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:52938270C>A	uc003gzl.2	+	6	984	c.706C>A	c.(706-708)CTG>ATG	p.L236M	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.L204M|SPATA18_uc003gzk.1_Missense_Mutation_p.L236M	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	236	Potential.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GCTCCGAAACCTGAAGGAGGA	0.483													13	68					1.05317e-09	1.07565e-09	1	0	A	52938270	A	A	52938270	3	1	276	1	0	0	0	0	1	0	0	0	15069	680	24	4	728	4	SPATA18	4	52938270	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4395794	52938270	138216006	440	50329											
FIP1L1	81608	broad.mit.edu	37	chr4	54294260	54294260	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaccacctccgtttttccctCcaggagctcctcccactcac	7	10	4	20	1	1	0	1	0	0	0	6	1	6	1	7	1	2	2	7	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:54294260C>T	uc003gzy.2	+	13	1270	c.1084C>T	c.(1084-1086)CCA>TCA	p.P362S	PDGFRA_uc003haa.2_Intron|FIP1L1_uc003gzx.3_Missense_Mutation_p.P347S|FIP1L1_uc011bzt.1_Missense_Mutation_p.P326S|FIP1L1_uc011bzu.1_Missense_Mutation_p.P347S|FIP1L1_uc003gzz.2_Missense_Mutation_p.P288S|FIP1L1_uc003hab.2_Missense_Mutation_p.P327S|FIP1L1_uc003hac.2_Missense_Mutation_p.P107S|FIP1L1_uc010ign.2_RNA|FIP1L1_uc003had.2_5'UTR|FIP1L1_uc003hae.2_5'UTR	NM_030917	NP_112179	Q6UN15	FIP1_HUMAN	FIP1 like 1 isoform 1	362	Pro-rich.				mRNA processing	nucleus	RNA binding			ovary(1)|skin(1)	2			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			GTTTTTCCCTCCAGGAGctcc	0.333			T	PDGFRA	idiopathic hypereosinophilic syndrome								4	44					0	0	0	0	T	54294260	T	T	54294260	3	4	276	1	0	0	0	0	1	0	0	0	5928	855	30	2	1134	2	FIP1L1	4	54294260	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1355990	54294260	136860016	441	50330											
KIAA1211	57482	broad.mit.edu	37	chr4	57181222	57181223	+	Missense_Mutation	DNP	GG	AA	AA																															gcccttgaacaaggccgcaaGgtggaggagctgcggtggca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:57181222_57181223GG>AA	uc003hbk.2	+	8	1945_1946	c.1554_1555GG>AA	c.(1552-1557)AAGGTG>AAAATG	p.V519M	KIAA1211_uc010iha.2_Missense_Mutation_p.V512M|KIAA1211_uc011bzz.1_Missense_Mutation_p.V429M|KIAA1211_uc003hbm.1_Missense_Mutation_p.V405M	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	519	Glu-rich.									ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					AAGGCCGCAAGGTGGAGGAGCT	0.639													5	27					0	0	0	0	AA	57181223	AA	AA	57181222	3	1	276	1	0	0	0	0	1	0	0	0	8254	991	35	4	1572	4	KIAA1211	4	57181222	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	2886962	57181222	133973054	442	50331											
ARL9	132946	broad.mit.edu	37	chr4	57389990	57389990	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggctcagagataccctccaCcatgcaagatgccaaagact	13	7	8	13	0	1	3	1	0	0	3	2	4	2	3	4	1	3	2	4	1	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:57389990C>T	uc003hby.1	+	4	768	c.320C>T	c.(319-321)ACC>ATC	p.T107I		NM_206919	NP_996802	Q6T311	ARL9_HUMAN	ADP-ribosylation factor-like 9	171							GTP binding				0	Glioma(25;0.08)|all_neural(26;0.101)					ATACCCTCCACCATGCAAGAT	0.488													8	50					0	0	0	0	T	57389990	T	T	57389990	3	4	276	1	0	0	0	0	1	0	0	0	950	507	18	4	330	4	ARL9	4	57389990	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	208768	57389990	133764286	443	50332											
C4orf14	84273	broad.mit.edu	37	chr4	57842906	57842906	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcgctgtggcccttggtgGccaggggccagcaggagccc	4	5	19	13	1	0	0	0	0	0	0	0	1	0	1	4	7	2	2	4	7	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:57842906G>A	uc003hck.2	-	1	921	c.846C>T	c.(844-846)GGC>GGT	p.G282G	POLR2B_uc003hcl.1_5'Flank|POLR2B_uc011cae.1_5'Flank|POLR2B_uc011caf.1_5'Flank	NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	282							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					GCCCTTGGTGGCCAGGGGCCA	0.697													5	38					0	0	0	0	A	57842906	A	A	57842906	2	1	276	1	0	0	0	0	0	0	0	1	2261	1190	42	4		4	C4orf14	4	57842906	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	452916	57842906	133311370	444	50333											
UGT2B10	7365	broad.mit.edu	37	chr4	69682215	69682215	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	taccctgtggtgagctgctgGctgagctatttaacataccc	8	12	10	11	0	0	2	0	2	0	0	0	2	0	2	2	2	6	4	2	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:69682215G>C	uc003hee.2	+	1	503	c.478G>C	c.(478-480)GCT>CCT	p.A160P	UGT2B10_uc011cam.1_Intron	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	160					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TGAGCTGCTGGCTGAGCTATT	0.393													47	112					0	0	0	0	C	69682215	C	C	69682215	3	2	276	1	0	0	0	0	1	0	0	0	17024	1203	42	4	480	4	UGT2B10	4	69682215	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	11839309	69682215	121472061	445	50334											
UGT2B10	7365	broad.mit.edu	37	chr4	69682395	69682395	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctctatgtgctttattttGacttttggttccaaatattt	7	22	6	6	0	1	1	0	1	1	0	2	1	2	1	1	1	2	3	1	1	4	10			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:69682395G>T	uc003hee.2	+	1	683	c.658G>T	c.(658-660)GAC>TAC	p.D220Y	UGT2B10_uc011cam.1_Intron	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	220					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GCTTTATTTTGACTTTTGGTT	0.308													14	65					1.05317e-09	1.07565e-09	1	0	T	69682395	T	T	69682395	3	4	276	1	0	0	0	0	1	0	0	0	17024	1290	45	2	660	2	UGT2B10	4	69682395	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	180	69682395	121471881	446	50335											
UGT2B7	7364	broad.mit.edu	37	chr4	69962535	69962535	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagattaagagatggtcagaCcttccaaaagatacattttg	15	11	8	7	0	1	4	1	0	0	4	2	5	2	4	2	1	1	0	2	1	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:69962535C>T	uc003heg.3	+	1	343	c.297C>T	c.(295-297)GAC>GAT	p.D99D	UGT2B7_uc010ihq.2_Silent_p.D99D	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	99					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GATGGTCAGACCTTCCAAAAG	0.323													21	59					0	0	0	0	T	69962535	T	T	69962535	2	4	276	1	0	0	0	0	0	0	0	1	17030	506	18	4		4	UGT2B7	4	69962535	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	280140	69962535	121191741	447	50336											
UGT2A1	10941	broad.mit.edu	37	chr4	70462099	70462099	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctggataaattcttccatttCctgcatacataatatatttt	12	18	3	8	0	1	0	0	0	1	0	3	1	3	1	2	1	2	1	2	1	6	10			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:70462099C>T	uc003hem.3	-	3	928	c.865G>A	c.(865-867)GAA>AAA	p.E289K	UGT2A1_uc011caq.1_Intron|UGT2A1_uc010ihu.2_Intron|UGT2A1_uc010iht.2_Intron|UGT2A1_uc010ihs.2_Missense_Mutation_p.E290K	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	289	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						TCTTCCATTTCCTGCATACAT	0.308													9	54					0	0	0	0	T	70462099	T	T	70462099	3	4	276	1	0	0	0	0	1	0	0	0	17021	869	30	2	734	2	UGT2A1	4	70462099	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	499564	70462099	120692177	448	50337											
CSN1S1	1446	broad.mit.edu	37	chr4	70810588	70810588	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctttccagcagctcaaccaActtgctgcctacccctatgc	8	10	5	18	0	1	0	1	0	0	0	2	0	2	0	6	0	8	3	6	0	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:70810588A>G	uc003hep.1	+	15	472	c.423A>G	c.(421-423)CAA>CAG	p.Q141Q	CSN1S1_uc003heq.1_Silent_p.Q132Q|CSN1S1_uc003her.1_Silent_p.Q133Q	NM_001890	NP_001881	P47710	CASA1_HUMAN	casein alpha s1 isoform 1	141						extracellular region	protein binding|transporter activity				0						AGCTCAACCAACTTGCTGCCT	0.423													123	249					0	0	0	0	G	70810588	G	G	70810588	2	3	276	1	0	0	0	0	0	0	0	1	3964	40	2	5		5	CSN1S1	4	70810588	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	348489	70810588	120343688	449	50338											
C4orf40	401137	broad.mit.edu	37	chr4	71020140	71020140	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtatgtgttgcttttgcaagGaaggtaagtaaatggacttc	11	14	12	4	0	0	0	0	0	0	0	1	2	0	2	0	3	2	6	0	3	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:71020140G>A	uc003hfa.3	+	2	121	c.48G>A	c.(46-48)AGG>AGA	p.R16R	C4orf40_uc003hfb.3_Silent_p.R16R	NM_214711	NP_999876	Q6MZM9	CD040_HUMAN	hypothetical protein LOC401137 precursor	16						extracellular region					0						CTTTTGCAAGGAAGGTAAGTA	0.303													7	35					0	0	0	0	A	71020140	A	A	71020140	2	1	276	1	0	0	0	0	0	0	0	1	2279	1165	41	2		2	C4orf40	4	71020140	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	209552	71020140	120134136	450	50339											
ODAM	54959	broad.mit.edu	37	chr4	71068544	71068544	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgacagtgcaggagttttCatgccctcaacttcaccaaa	12	10	7	12	0	3	1	3	1	0	0	3	2	3	2	2	1	3	2	2	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:71068544C>T	uc003hfc.2	+	9	737	c.720C>T	c.(718-720)TTC>TTT	p.F240F		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	240					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						CAGGAGTTTTCATGCCCTCAA	0.408													13	34					0	0	0	0	T	71068544	T	T	71068544	2	4	276	1	0	0	0	0	0	0	0	1	10878	825	29	2		2	ODAM	4	71068544	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	48404	71068544	120085732	451	50340											
MUC7	4589	broad.mit.edu	37	chr4	71347144	71347144	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tacaccagctccaccatcttCctcagctccaccagagacca	11	7	4	19	0	2	1	1	0	1	1	5	2	5	1	7	0	3	2	7	0	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:71347144C>T	uc011cat.1	+	4	971	c.683C>T	c.(682-684)TCC>TTC	p.S228F	MUC7_uc011cau.1_Missense_Mutation_p.S228F|MUC7_uc003hfj.2_Missense_Mutation_p.S228F|uc011cav.1_Intron	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	228	3.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			CCACCATCTTCCTCAGCTCCA	0.582													29	103					0	0	0	0	T	71347144	T	T	71347144	3	4	276	1	0	0	0	0	1	0	0	0	10034	855	30	2	689	2	MUC7	4	71347144	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	278600	71347144	119807132	452	50341											
SLC4A4	8671	broad.mit.edu	37	chr4	72397869	72397869	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taggcgtggacaccccaaaaCtaattgtgccaagtgagttc	12	9	10	10	1	0	1	0	1	0	0	1	2	0	2	3	2	2	1	3	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:72397869C>T	uc003hfy.2	+	17	2374	c.2257C>T	c.(2257-2259)CTA>TTA	p.L753L	SLC4A4_uc010iic.2_Silent_p.L753L|SLC4A4_uc010iib.2_Silent_p.L753L|SLC4A4_uc003hfz.2_Silent_p.L753L|SLC4A4_uc003hgc.3_Silent_p.L709L|SLC4A4_uc010iid.2_5'UTR	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	753	Interaction with CA4.|Extracellular (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CACCCCAAAACTAATTGTGCC	0.383													7	47					0	0	0	0	T	72397869	T	T	72397869	2	4	276	1	0	0	0	0	0	0	0	1	14720	564	20	4		4	SLC4A4	4	72397869	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1050725	72397869	118756407	453	50342											
SLC4A4	8671	broad.mit.edu	37	chr4	72425848	72425848	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtcagaaaaggcatggactaCctcttctcccagcacgacct	11	8	8	14	1	3	1	1	0	2	1	4	3	3	2	3	2	2	2	3	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:72425848C>T	uc003hfy.2	+	23	3093	c.2976C>T	c.(2974-2976)TAC>TAT	p.Y992Y	SLC4A4_uc010iic.2_Silent_p.Y992Y|SLC4A4_uc010iib.2_Silent_p.Y908Y|SLC4A4_uc003hfz.2_Silent_p.Y992Y|SLC4A4_uc003hgc.3_Silent_p.Y948Y|SLC4A4_uc010iid.2_Silent_p.Y196Y	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	992	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GCATGGACTACCTCTTCTCCC	0.343													29	106					0	0	0	0	T	72425848	T	T	72425848	2	4	276	1	0	0	0	0	0	0	0	1	14720	518	18	4		4	SLC4A4	4	72425848	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	27979	72425848	118728428	454	50343											
ALB	213	broad.mit.edu	37	chr4	74279194	74279194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgatctccagtaaactgaagGaatgctgtgaaaaacctctg	14	9	9	9	1	2	2	0	2	2	0	3	4	2	3	2	1	3	2	2	1	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:74279194G>A	uc003hgs.3	+	8	974	c.901G>A	c.(901-903)GAA>AAA	p.E301K	ALB_uc003hgw.3_Missense_Mutation_p.E109K|ALB_uc011cbe.1_5'UTR|ALB_uc003hgt.3_Missense_Mutation_p.E301K|ALB_uc010iii.2_Missense_Mutation_p.E186K|ALB_uc003hgu.3_Missense_Mutation_p.E151K|ALB_uc003hgv.3_5'UTR|ALB_uc011cbf.1_Missense_Mutation_p.E191K|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'UTR	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	301	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TAAACTGAAGGAATGCTGTGA	0.408													19	54					0	0	0	0	A	74279194	A	A	74279194	3	1	276	1	0	0	0	0	1	0	0	0	486	1175	41	2	931	2	ALB	4	74279194	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1853346	74279194	116875082	455	50344											
BTC	685	broad.mit.edu	37	chr4	75673329	75673329	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttccatttcttcttctttCttctttcttttacgacgttt	3	25	3	10	2	6	0	0	0	6	0	7	1	7	0	1	0	1	2	1	0	1	10			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:75673329C>T	uc003hig.2	-	5	806	c.459G>A	c.(457-459)AAG>AAA	p.K153K		NM_001729	NP_001720	P35070	BTC_HUMAN	betacellulin precursor	153	Cytoplasmic (Potential).|Arg/Lys-rich (basic).				positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|skin(1)	2			Lung(101;0.219)			CTTCTTCTTTCTTCTTTCTTT	0.353													15	59					0	0	0	0	T	75673329	T	T	75673329	2	4	276	1	0	0	0	0	0	0	0	1	1554	912	32	2		2	BTC	4	75673329	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1394135	75673329	115480947	456	50345											
C4orf26	152816	broad.mit.edu	37	chr4	76489445	76489445	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggtcacaagggcccagccCatcacaaagacacccaggtg	12	3	10	16	1	2	1	2	0	0	1	2	1	2	1	4	3	1	0	4	3	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:76489445C>T	uc003hip.1	+	2	224	c.189C>T	c.(187-189)CCC>CCT	p.P63P	C4orf26_uc011cbn.1_RNA|C4orf26_uc011cbo.1_Missense_Mutation_p.P78L	NM_178497	NP_848592	Q17RF5	CD026_HUMAN	hypothetical protein LOC152816 precursor	63						extracellular region					0			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			GGGCCCAGCCCATCACAAAGA	0.527													18	69					0	0	0	0	T	76489445	T	T	76489445	2	4	276	1	0	0	0	0	0	0	0	1	2267	581	21	4		4	C4orf26	4	76489445	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	816116	76489445	114664831	457	50346											
SHROOM3	57619	broad.mit.edu	37	chr4	77631416	77631416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaaagcagcgtggtcaggagGggttaaacttcggctgaagc	11	7	16	7	2	1	1	1	1	0	0	2	3	1	2	0	5	4	3	0	5	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:77631416G>A	uc011cbx.1	+	3	1384	c.431G>A	c.(430-432)GGG>GAG	p.G144E	SHROOM3_uc011cbz.1_5'UTR	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	144					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			TGGTCAGGAGGGGTTAAACTT	0.567													7	43					0	0	0	0	A	77631416	A	A	77631416	3	1	276	1	0	0	0	0	1	0	0	0	14360	1232	43	4	441	4	SHROOM3	4	77631416	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1141971	77631416	113522860	458	50347											
ANKRD56	345079	broad.mit.edu	37	chr4	77817038	77817038	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaggacaatccctgccttCtttgctccagacaccaagtc	10	10	6	15	0	2	1	1	0	1	1	5	2	4	2	4	1	2	1	4	1	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:77817038C>G	uc003hki.2	-	1	1965	c.1965G>C	c.(1963-1965)AAG>AAC	p.K655N		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	655	ANK 1.										0						TCCCTGCCTTCTTTGCTCCAG	0.532													23	110					0	0	0	0	G	77817038	G	G	77817038	3	3	276	1	0	0	0	0	1	0	0	0	682	912	32	2	420	2	ANKRD56	4	77817038	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	185622	77817038	113337238	459	50348											
FGF5	2250	broad.mit.edu	37	chr4	81188003	81188003	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttgtccttcctcctcctcCtcttcttcagccacctgatc	3	15	4	19	0	3	1	1	1	2	0	9	1	8	1	7	0	1	1	7	0	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:81188003C>T	uc003hmd.2	+	1	262	c.25C>T	c.(25-27)CTC>TTC	p.L9F	FGF5_uc003hme.2_Missense_Mutation_p.L9F	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	9					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						CCTCCTCCTCCTCTTCTTCAG	0.627													3	68					0	0	0	0	T	81188003	T	T	81188003	3	4	276	1	0	0	0	0	1	0	0	0	5887	681	24	4	27	4	FGF5	4	81188003	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3370965	81188003	109966273	460	50349											
MAPK10	5602	broad.mit.edu	37	chr4	86988967	86988967	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccgctgggaagagggaaTctgggaagagtttggggaag	11	7	19	4	1	1	2	0	0	1	2	2	6	2	6	1	5	0	2	1	5	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:86988967T>G	uc003hpq.2	-	9	1011	c.944A>C	c.(943-945)GAT>GCT	p.D315A	MAPK10_uc010ikg.2_Missense_Mutation_p.D277A|MAPK10_uc003hpr.2_Missense_Mutation_p.D277A|MAPK10_uc003hps.2_Missense_Mutation_p.D315A|MAPK10_uc003hpt.2_Missense_Mutation_p.D315A|MAPK10_uc003hpu.2_Missense_Mutation_p.D315A|MAPK10_uc003hpv.2_Missense_Mutation_p.D170A|MAPK10_uc003hpn.2_Missense_Mutation_p.D63A|MAPK10_uc003hpo.2_Missense_Mutation_p.D170A|MAPK10_uc011ccw.1_Missense_Mutation_p.D201A|MAPK10_uc003hpp.2_Missense_Mutation_p.D170A	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	315	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		GAAGAGGGAATCTGGGAAGAG	0.493													21	32					0	0	0	0	G	86988967	G	G	86988967	3	3	276	1	0	0	0	0	1	0	0	0	9325	1435	50	5	475	5	MAPK10	4	86988967	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	5800964	86988967	104165309	461	50350											
AFF1	4299	broad.mit.edu	37	chr4	88047294	88047294	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctcaaagaaggaaatgctcCccccgccacccgtgtcctcg	9	6	8	18	3	1	1	1	0	0	1	4	2	3	2	7	1	1	1	7	1	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:88047294C>T	uc003hqj.3	+	13	3003	c.2596C>T	c.(2596-2598)CCC>TCC	p.P866S	AFF1_uc011ccz.1_Missense_Mutation_p.P873S|AFF1_uc003hqk.3_Missense_Mutation_p.P866S|AFF1_uc011cda.1_Missense_Mutation_p.P504S	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	866	Poly-Pro.					nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GGAAATGCTCCCCCCGCCACC	0.577													15	60					0	0	0	0	T	88047294	T	T	88047294	3	4	276	1	0	0	0	0	1	0	0	0	356	623	22	4	2688	4	AFF1	4	88047294	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1058327	88047294	103106982	462	50351											
SPARCL1	8404	broad.mit.edu	37	chr4	88394947	88394947	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaaacaagagattttcatCtatgtcctctataaaaaaac	18	12	3	8	0	4	1	2	0	2	1	5	2	5	1	1	0	2	0	1	0	9	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:88394947C>T	uc010ikm.2	-	12	2547	c.1975G>A	c.(1975-1977)GAT>AAT	p.D659N	SPARCL1_uc011cdc.1_Missense_Mutation_p.D534N|SPARCL1_uc003hqs.3_Missense_Mutation_p.D659N|SPARCL1_uc011cdd.1_Missense_Mutation_p.D534N	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	659					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		AGATTTTCATCTATGTCCTCT	0.348													29	114					0	0	0	0	T	88394947	T	T	88394947	3	4	276	1	0	0	0	0	1	0	0	0	15062	913	32	2	23	2	SPARCL1	4	88394947	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	347653	88394947	102759329	463	50352											
IBSP	3381	broad.mit.edu	37	chr4	88732536	88732536	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggggatataacaaataaagCtacaaaagagaaggaaagtg	21	6	11	3	0	0	1	0	0	0	1	0	4	0	3	0	3	3	1	0	3	10	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:88732536C>T	uc003hqx.3	+	7	526	c.428C>T	c.(427-429)GCT>GTT	p.A143V		NM_004967	NP_004958	P21815	SIAL_HUMAN	integrin-binding sialoprotein precursor	143	Asp/Glu-rich (acidic).				biomineral tissue development|cell adhesion|ossification						0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		ACAAATAAAGCTACAAAAGAG	0.264													8	19					0	0	0	0	T	88732536	T	T	88732536	3	4	276	1	0	0	0	0	1	0	0	0	7514	797	28	4	450	4	IBSP	4	88732536	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	337589	88732536	102421740	464	50353											
UNC5C	8633	broad.mit.edu	37	chr4	96091343	96091343	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggccagcatcctccagtcAtggcctctcgtctggggggc	4	9	14	14	1	3	0	1	0	2	0	6	0	5	0	4	5	1	1	4	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:96091343A>T	uc003htp.1	-	15	2746	c.2592T>A	c.(2590-2592)CAT>CAA	p.H864Q	uc003hto.2_5'Flank	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	864	Cytoplasmic (Potential).|Death.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TCCTCCAGTCATGGCCTCTCG	0.587													55	120					0	0	0	0	T	96091343	T	T	96091343	3	4	276	1	0	0	0	0	1	0	0	0	17061	214	8	5	211	5	UNC5C	4	96091343	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	7358807	96091343	95062933	465	50354											
UNC5C	8633	broad.mit.edu	37	chr4	96106245	96106245	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagagggaatgggcgatatCgtgaattgacaggcgcaggt	11	7	16	7	3	0	3	0	2	0	1	1	5	0	4	1	4	0	1	1	4	3	2	rs139502011	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:96106245C>T	uc003htp.1	-	13	2393	c.2239G>A	c.(2239-2241)GAT>AAT	p.D747N	UNC5C_uc010ilc.1_Missense_Mutation_p.D766N	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	747	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TGGGCGATATCGTGAATTGAC	0.463													21	93					0	0	0	0	T	96106245	T	T	96106245	3	4	276	1	0	0	0	0	1	0	0	0	17061	884	31	1	572	1	UNC5C	4	96106245	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	14902	96106245	95048031	466	50355											
LRIT3	345193	broad.mit.edu	37	chr4	110788925	110788925	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgaacctgagcgcctcacaGgaattttgtttcagcgggct	8	11	12	10	2	2	2	2	2	0	0	2	3	2	3	2	2	3	2	2	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:110788925G>A	uc003hzx.3	+	2	776	c.583G>A	c.(583-585)GGA>AGA	p.G195R	LRIT3_uc003hzw.3_Missense_Mutation_p.G57R	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	195	LRRCT.					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		GCGCCTCACAGGAATTTTGTT	0.458													33	59					0	0	0	0	A	110788925	A	A	110788925	3	1	276	1	0	0	0	0	1	0	0	0	8999	1001	35	4	589	4	LRIT3	4	110788925	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	14682680	110788925	80365351	467	50356											
EGF	1950	broad.mit.edu	37	chr4	110884392	110884393	+	Nonsense_Mutation	DNP	GG	AA	AA																															tcctcttagcccagtatcctGggaatgtgattgctttcctg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:110884392_110884393GG>AA	uc003hzy.3	+	9	1828_1829	c.1376_1377GG>AA	c.(1375-1377)TGG>TAA	p.W459*	EGF_uc011cfu.1_Nonsense_Mutation_p.W417*|EGF_uc011cfv.1_Nonsense_Mutation_p.W459*	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	459	EGF-like 4.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CCAGTATCCTGGGAATGTGATT	0.455													25	113					0	0	0	0	AA	110884393	AA	AA	110884392	4	1	276	1	0	0	0	0	0	1	0	0	4984	1357	47	4	1410	4	EGF	4	110884392	Nonsense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	95467	110884392	80269884	468	50357											
ANKRD50	57182	broad.mit.edu	37	chr4	125590149	125590150	+	Missense_Mutation	DNP	GG	AA	AA																															aaaatattaccttttataatGgtgtttcctttttatagttg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:125590149_125590150GG>AA	uc003ifg.3	-	3	4548_4549	c.4282_4283CC>TT	c.(4282-4284)CCA>TTA	p.P1428L	ANKRD50_uc011cgo.1_Missense_Mutation_p.P1249L|ANKRD50_uc010inw.2_Missense_Mutation_p.P1428L	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1428										central_nervous_system(1)	1						CTTTTATAATGGTGTTTCCTTT	0.267													15	33					0	0	0	0	AA	125590150	AA	AA	125590149	3	1	276	1	0	0	0	0	1	0	0	0	677	1348	47	4	10	4	ANKRD50	4	125590149	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	14705757	125590149	65564127	469	50358											
FAT4	79633	broad.mit.edu	37	chr4	126241562	126241562	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaaacatgagaattggtgaActcgtgtcctctgttactgc	11	12	10	8	1	1	2	0	2	1	1	3	4	2	2	1	1	4	1	1	1	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:126241562A>G	uc003ifj.3	+	1	3996	c.3996A>G	c.(3994-3996)GAA>GAG	p.E1332E		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1332	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GAATTGGTGAACTCGTGTCCT	0.348													14	98					0	0	0	0	G	126241562	G	G	126241562	2	3	276	1	0	0	0	0	0	0	0	1	5724	40	2	5		5	FAT4	4	126241562	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	651413	126241562	64912714	470	50359											
FAT4	79633	broad.mit.edu	37	chr4	126411359	126411360	+	Missense_Mutation	DNP	CC	TT	TT																															agactcgcacacgggaaggaCctgtgagatggtggtggcct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:126411359_126411360CC>TT	uc003ifj.3	+	17	13382_13383	c.13382_13383CC>TT	c.(13381-13383)ACC>ATT	p.T4461I	FAT4_uc011cgp.1_Missense_Mutation_p.T2702I|FAT4_uc003ifi.1_Missense_Mutation_p.T1938I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4461	EGF-like 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACGGGAAGGACCTGTGAGATGG	0.634													17	57					0	0	0	0	TT	126411360	TT	TT	126411359	3	4	276	1	0	0	0	0	1	0	0	0	5724	507	18	4	13448	4	FAT4	4	126411359	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	169797	126411359	64742917	471	50360											
PHF17	79960	broad.mit.edu	37	chr4	129778492	129778492	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgctgttttccgacctttaGgtgagcattggcagcccaga	7	13	11	10	1	0	2	0	1	0	1	1	3	1	2	3	2	3	4	3	2	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:129778492G>A	uc003igk.2	+	8	1145	c.865_splice	c.e8-1	p.V289_splice	PHF17_uc003igj.2_Splice_Site_p.V289_splice|PHF17_uc003igl.2_Splice_Site_p.V277_splice|PHF17_uc011cgy.1_Splice_Site_p.V289_splice|PHF17_uc003igm.2_Splice_Site_p.V289_splice	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform						apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						CCGACCTTTAGGTGAGCATTG	0.507													50	92					0	0	0	0	A	129778492	A	A	129778492	5	1	276	1	0	0	0	0	0	0	1	0	11883	1014	35	4	890	4	PHF17	4	129778492	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3367133	129778492	61375784	472	50361											
HHIP	64399	broad.mit.edu	37	chr4	145580019	145580019	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggttgtgctttccagattttCcaagaaaacaagtcagagga	13	11	10	7	0	1	3	1	0	0	3	3	4	3	4	2	2	2	2	2	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:145580019C>T	uc003ijs.1	+	3	1205	c.550C>T	c.(550-552)CCA>TCA	p.P184S	HHIP_uc003ijr.1_Missense_Mutation_p.P184S	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	184						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TCCAGATTTTCCAAGAAAACA	0.373													28	85					0	0	0	0	T	145580019	T	T	145580019	3	4	276	1	0	0	0	0	1	0	0	0	7131	855	30	2	560	2	HHIP	4	145580019	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	15801527	145580019	45574257	473	50362											
MAB21L2	10586	broad.mit.edu	37	chr4	151504695	151504695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctatgtggtgcaaatcactCcggcgttcaagtgcaccggg	8	9	13	11	3	2	0	2	0	0	0	3	0	3	0	2	3	2	4	2	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:151504695C>T	uc003ilw.2	+	1	1619	c.514C>T	c.(514-516)CCG>TCG	p.P172S	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	172					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		GCAAATCACTCCGGCGTTCAA	0.637													10	46					0	0	0	0	T	151504695	T	T	151504695	3	4	276	1	0	0	0	0	1	0	0	0	9193	855	30	2	516	2	MAB21L2	4	151504695	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5924676	151504695	39649581	474	50363											
RNF175	285533	broad.mit.edu	37	chr4	154641439	154641439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acacaatgccaaaatccatgGaatctctagctttgattcta	14	12	5	10	0	2	1	0	1	2	0	4	2	3	2	2	1	2	1	2	1	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:154641439G>A	uc003int.2	-	6	900	c.527C>T	c.(526-528)TCC>TTC	p.S176F	RNF175_uc003inu.1_Missense_Mutation_p.S48F	NM_173662	NP_775933	Q8N4F7	RN175_HUMAN	ring finger protein 175	176						integral to membrane	zinc ion binding			ovary(1)|pancreas(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				AAAATCCATGGAATCTCTAGC	0.398													16	62					0	0	0	0	A	154641439	A	A	154641439	3	1	276	1	0	0	0	0	1	0	0	0	13528	1174	41	2	475	2	RNF175	4	154641439	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3136744	154641439	36512837	475	50364											
DCHS2	54798	broad.mit.edu	37	chr4	155157613	155157613	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgaattttgtcattttttCataatccagaggtttaatca	11	18	7	5	0	3	2	3	1	0	1	4	2	4	2	1	2	0	1	1	2	3	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:155157613C>T	uc003inw.2	-	25	6826	c.6826G>A	c.(6826-6828)GAA>AAA	p.E2276K		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2276	Cadherin 20.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GTCATTTTTTCATAATCCAGA	0.343													15	76					0	0	0	0	T	155157613	T	T	155157613	3	4	276	1	0	0	0	0	1	0	0	0	4305	835	29	2	1928	2	DCHS2	4	155157613	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	516174	155157613	35996663	476	50365											
FGG	2266	broad.mit.edu	37	chr4	155533728	155533728	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaagagcatagaagtagaGaattaaattccgggggtgca	17	8	12	4	1	0	3	0	0	0	3	1	4	1	3	1	2	2	3	1	2	8	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:155533728G>A	uc003ioj.2	-	1	175	c.34C>T	c.(34-36)CTC>TTC	p.L12F	FGG_uc003iog.2_Missense_Mutation_p.L12F|FGG_uc003ioh.2_Missense_Mutation_p.L12F|FGG_uc010ipx.2_5'UTR|FGG_uc010ipy.2_5'UTR|FGG_uc003ioi.2_5'Flank|FGG_uc003iok.2_Missense_Mutation_p.L12F	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	12					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TAGAAGTAGAGAATTAAATTC	0.438													12	65					0	0	0	0	A	155533728	A	A	155533728	3	1	276	1	0	0	0	0	1	0	0	0	5902	942	33	2	1382	2	FGG	4	155533728	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	376115	155533728	35620548	477	50366											
ADAM29	11086	broad.mit.edu	37	chr4	175898866	175898866	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgacctcatgagttacctccCcagagtcaaccttgggtgat	9	10	9	13	1	2	3	2	2	0	1	3	4	3	3	5	1	2	1	5	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:175898866C>T	uc003iuc.2	+	5	2860	c.2190C>T	c.(2188-2190)CCC>CCT	p.P730P	ADAM29_uc003iud.2_Silent_p.P730P|ADAM29_uc010irr.2_Silent_p.P730P|ADAM29_uc011cki.1_Silent_p.P730P	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	730	Cytoplasmic (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AGTTACCTCCCCAGAGTCAAC	0.463													20	88					0	0	0	0	T	175898866	T	T	175898866	2	4	276	1	0	0	0	0	0	0	0	1	247	610	22	4		4	ADAM29	4	175898866	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	20365138	175898866	15255410	478	50367											
WDR17	116966	broad.mit.edu	37	chr4	177041154	177041154	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaaagatgctcatagcttCttgtctgatatctgtatgtt	10	16	7	8	0	4	2	1	1	3	1	4	2	4	2	0	0	2	4	0	0	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:177041154C>T	uc003iuj.2	+	5	672	c.516C>T	c.(514-516)TTC>TTT	p.F172F	WDR17_uc003iuk.2_Silent_p.F148F|WDR17_uc003ium.3_Silent_p.F148F|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	172	WD 3.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CTCATAGCTTCTTGTCTGATA	0.423													29	125					0	0	0	0	T	177041154	T	T	177041154	2	4	276	1	0	0	0	0	0	0	0	1	17345	912	32	2		2	WDR17	4	177041154	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1142288	177041154	14113122	479	50368											
WDR17	116966	broad.mit.edu	37	chr4	177077242	177077242	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tattgtagtgggacaaagccCtgtcaattgcaccaggagtc	11	10	11	9	0	1	0	1	0	0	0	2	2	1	2	2	2	2	2	2	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:177077242C>T	uc003iuj.2	+	19	2701	c.2545C>T	c.(2545-2547)CTG>TTG	p.L849L	WDR17_uc003iuk.2_Silent_p.L825L|WDR17_uc003ium.3_Silent_p.L825L|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Silent_p.L68L	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	849										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GGACAAAGCCCTGTCAATTGC	0.373													27	108					0	0	0	0	T	177077242	T	T	177077242	2	4	276	1	0	0	0	0	0	0	0	1	17345	680	24	4		4	WDR17	4	177077242	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	36088	177077242	14077034	480	50369											
ODZ3	55714	broad.mit.edu	37	chr4	183659600	183659600	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtttggacctgactctgtgGgaaaagaggactgccattct	9	12	12	8	0	2	2	0	1	2	1	2	5	2	5	2	3	1	1	2	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:183659600G>A	uc003ivd.1	+	17	3319	c.3282G>A	c.(3280-3282)TGG>TGA	p.W1094*	ODZ3_uc003ive.1_Nonsense_Mutation_p.W500*	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1094	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TGACTCTGTGGGAAAAGAGGA	0.468													46	193					0	0	0	0	A	183659600	A	A	183659600	4	1	276	1	0	0	0	0	0	1	0	0	10890	1241	43	4	3348	4	ODZ3	4	183659600	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6582358	183659600	7494676	481	50370											
CCDC111	201973	broad.mit.edu	37	chr4	185578379	185578379	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaccgttgtcctcagtgtatAgaccaagattgtccaagcca	12	10	8	11	1	1	2	1	0	0	2	3	2	3	2	5	0	2	2	5	0	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:185578379A>G	uc003iwk.2	+	3	518	c.85A>G	c.(85-87)AGA>GGA	p.R29G	CCDC111_uc010isd.1_RNA|CCDC111_uc003iwj.2_Missense_Mutation_p.R29G|CCDC111_uc003iwl.2_Missense_Mutation_p.R29G|CCDC111_uc003iwm.2_Intron|CCDC111_uc003iwn.2_Translation_Start_Site	NM_152683	NP_689896	Q96LW4	CC111_HUMAN	coiled-coil domain containing 111	29					DNA replication, synthesis of RNA primer		DNA primase activity			central_nervous_system(1)	1		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)		CTCAGTGTATAGACCAAGATT	0.393													3	61					0	0	0	0	G	185578379	G	G	185578379	3	3	276	1	0	0	0	0	1	0	0	0	2760	412	15	5	87	5	CCDC111	4	185578379	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1918779	185578379	5575897	482	50371											
SORBS2	8470	broad.mit.edu	37	chr4	186536271	186536271	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	taccaattttgatcaattttCctgaggatgtagacagtatc	12	15	7	7	0	1	3	1	2	0	1	3	4	2	4	2	1	1	2	2	1	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr4:186536271C>T	uc003iyl.2	-	16	3540	c.2682G>A	c.(2680-2682)AGG>AGA	p.R894R	SORBS2_uc003iyh.2_Silent_p.R618R|SORBS2_uc011ckw.1_Silent_p.R455R|SORBS2_uc003iyi.2_Silent_p.R525R|SORBS2_uc011ckx.1_Silent_p.R460R|SORBS2_uc003iyk.2_Silent_p.R438R|SORBS2_uc003iym.2_Silent_p.R994R|SORBS2_uc003iyn.1_Silent_p.R485R|SORBS2_uc011cku.1_Silent_p.R286R|SORBS2_uc011ckv.1_Silent_p.R798R|SORBS2_uc003iyd.2_Silent_p.R593R|SORBS2_uc003iye.2_Silent_p.R467R|SORBS2_uc003iya.2_Silent_p.R414R|SORBS2_uc003iyb.2_Silent_p.R367R|SORBS2_uc003iyc.2_Silent_p.R347R|SORBS2_uc003iyg.2_Silent_p.R1008R|SORBS2_uc003iyf.2_Silent_p.R430R|SORBS2_uc003iyo.1_Silent_p.R343R	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	894	SH3 1.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GATCAATTTTCCTGAGGATGT	0.438													20	82					0	0	0	0	T	186536271	T	T	186536271	2	4	276	1	0	0	0	0	0	0	0	1	14992	854	30	2		2	SORBS2	4	186536271	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	957892	186536271	4618005	483	50372											
SDHA	6389	broad.mit.edu	37	chr5	251133	251133	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caaaatcatgctgccgtgttCcgtgtgggaagcgtgttgca	8	11	13	9	3	1	0	1	0	0	0	2	1	2	1	2	1	4	4	2	1	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:251133C>T	uc003jao.3	+	12	1693	c.1578C>T	c.(1576-1578)TTC>TTT	p.F526F	SDHA_uc011clv.1_Silent_p.F526F|SDHA_uc011clw.1_Silent_p.F478F|SDHA_uc003jap.3_Intron|SDHA_uc003jaq.3_Silent_p.F301F|SDHA_uc003jar.3_Silent_p.F120F	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	526					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	CTGCCGTGTTCCGTGTGGGAA	0.448									Familial_Paragangliomas				15	81					0	0	0	0	T	251133	T	T	251133	2	4	276	1	0	0	0	0	0	0	0	1	14028	854	30	2		2	SDHA	5	251133	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08		251133	180664127	484	50373											
AHRR	57491	broad.mit.edu	37	chr5	376767	376767	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcagcctgcggccggcgcccCctcgcccggagacagctgtc	4	4	14	19	5	0	1	0	0	0	1	2	2	0	1	5	3	3	2	5	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:376767C>T	uc003jav.2	+	4	343	c.299C>T	c.(298-300)CCC>CTC	p.P100L	AHRR_uc003jaw.2_Missense_Mutation_p.P96L|AHRR_uc010isy.2_Intron|AHRR_uc010isz.2_Missense_Mutation_p.P96L	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GCCGGCGCCCCCTCGCCCGGA	0.627													6	19					0	0	0	0	T	376767	T	T	376767	3	4	276	1	0	0	0	0	1	0	0	0	417	623	22	4	313	4	AHRR	5	376767	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	125634	376767	180538493	485	50374											
SLC6A18	348932	broad.mit.edu	37	chr5	1240774	1240774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacgagcactgcctggacaGgtgagcacaggtgccgcgcc	8	5	14	14	3	0	1	0	1	0	0	0	3	0	2	3	3	5	2	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:1240774G>A	uc003jby.1	+	7	1097	c.974G>A	c.(973-975)AGA>AAA	p.R325K		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	325	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TGCCTGGACAGGTGAGCACAG	0.622													9	29					0	0	0	0	A	1240774	A	A	1240774	3	1	276	1	0	0	0	0	1	0	0	0	14745	1014	35	4	1000	4	SLC6A18	5	1240774	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	864007	1240774	179674486	486	50375											
SEMA5A	9037	broad.mit.edu	37	chr5	9224870	9224870	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aatggcaggatcacgtcctgGaaaatccatggctgtagcag	12	8	12	9	1	1	0	1	0	0	0	3	2	3	2	2	4	1	4	2	4	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:9224870G>A	uc003jek.2	-	8	1274	c.562C>T	c.(562-564)CCA>TCA	p.P188S		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	188	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TCACGTCCTGGAAAATCCATG	0.562													9	33					0	0	0	0	A	9224870	A	A	9224870	3	1	276	1	0	0	0	0	1	0	0	0	14102	1174	41	2	2726	2	SEMA5A	5	9224870	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7984096	9224870	171690390	487	50376											
CTNND2	1501	broad.mit.edu	37	chr5	11159760	11159760	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccgatcatcctgaagaggcGaattttcccagcctgagtgg	9	10	11	11	2	1	3	1	2	0	1	4	5	4	3	4	2	1	0	4	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:11159760G>A	uc003jfa.1	-	12	2232	c.2087C>T	c.(2086-2088)TCG>TTG	p.S696L	CTNND2_uc010itt.2_Missense_Mutation_p.S605L|CTNND2_uc011cmy.1_Missense_Mutation_p.S359L|CTNND2_uc011cmz.1_Missense_Mutation_p.S263L|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.S263L	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	696	ARM 5.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CTGAAGAGGCGAATTTTCCCA	0.537													24	87					0	0	0	0	A	11159760	A	A	11159760	3	1	276	1	0	0	0	0	1	0	0	0	4037	1059	37	1	1634	1	CTNND2	5	11159760	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1934890	11159760	169755500	488	50377											
DNAH5	1767	broad.mit.edu	37	chr5	13717484	13717484	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcacagtggcattaaagtcCgcttggttaaattcgtaggg	10	12	12	7	2	0	0	0	0	0	0	2	0	1	0	1	3	1	5	1	3	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:13717484C>T	uc003jfd.2	-	73	12687	c.12645G>A	c.(12643-12645)GCG>GCA	p.A4215A	DNAH5_uc003jfc.2_Silent_p.A383A	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4215	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CATTAAAGTCCGCTTGGTTAA	0.537									Kartagener_syndrome				4	28					0	0	0	0	T	13717484	T	T	13717484	2	4	276	1	0	0	0	0	0	0	0	1	4626	639	23	1		1	DNAH5	5	13717484	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2557724	13717484	167197776	489	50378											
DNAH5	1767	broad.mit.edu	37	chr5	13719151	13719151	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtttctatgattatgtcCatcagctcatccatgaaatc	11	15	5	10	0	4	2	3	2	1	0	7	2	6	2	2	0	1	2	2	0	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:13719151C>T	uc003jfd.2	-	72	12381	c.12339G>A	c.(12337-12339)ATG>ATA	p.M4113I	DNAH5_uc003jfc.2_Missense_Mutation_p.M281I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4113	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGATTATGTCCATCAGCTCAT	0.453									Kartagener_syndrome				15	55					0	0	0	0	T	13719151	T	T	13719151	3	4	276	1	0	0	0	0	1	0	0	0	4626	594	21	4	1567	4	DNAH5	5	13719151	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1667	13719151	167196109	490	50379											
DNAH5	1767	broad.mit.edu	37	chr5	13766128	13766128	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgcagtcatcaattttaagGattcctgccaggagggcatg	10	11	11	9	0	2	0	2	0	0	0	3	2	3	2	2	3	2	2	2	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:13766128G>A	uc003jfd.2	-	59	10100	c.10058C>T	c.(10057-10059)TCC>TTC	p.S3353F	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3353	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CAATTTTAAGGATTCCTGCCA	0.448									Kartagener_syndrome				29	121					0	0	0	0	A	13766128	A	A	13766128	3	1	276	1	0	0	0	0	1	0	0	0	4626	1174	41	2	3900	2	DNAH5	5	13766128	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	46977	13766128	167149132	491	50380											
MYO10	4651	broad.mit.edu	37	chr5	16668425	16668425	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctccctctcatcgaccacGatcttatacgtattcgccag	9	11	6	15	4	2	0	1	0	2	0	6	2	3	0	3	0	2	2	3	0	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:16668425G>A	uc003jft.3	-	40	6504	c.6036C>T	c.(6034-6036)ATC>ATT	p.I2012I	MYO10_uc011cnb.1_Silent_p.I641I|MYO10_uc011cnc.1_Silent_p.I891I|MYO10_uc011cnd.1_Silent_p.I1369I|MYO10_uc011cne.1_Silent_p.I1369I|MYO10_uc010itx.2_Silent_p.I1634I	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	2012	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CATCGACCACGATCTTATACG	0.478													71	102					0	0	0	0	A	16668425	A	A	16668425	2	1	276	1	0	0	0	0	0	0	0	1	10115	1048	37	1		1	MYO10	5	16668425	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2902297	16668425	164246835	492	50381											
PRDM9	56979	broad.mit.edu	37	chr5	23522980	23522980	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgaagaggcagccaacaatGgatactcctggctggtaaga	14	6	12	9	1	0	2	0	0	0	2	1	4	1	3	2	4	3	3	2	4	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:23522980G>A	uc003jgo.2	+	8	1050	c.868G>A	c.(868-870)GGA>AGA	p.G290R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	290	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGCCAACAATGGATACTCCTG	0.512										HNSCC(3;0.000094)			15	67					0	0	0	0	A	23522980	A	A	23522980	3	1	276	1	0	0	0	0	1	0	0	0	12525	1349	47	4	894	4	PRDM9	5	23522980	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6854555	23522980	157392280	493	50382											
PRDM9	56979	broad.mit.edu	37	chr5	23526913	23526913	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cacctcctcattcaccagagGatacacacaggggagaagcc	13	5	9	14	0	2	2	2	0	0	2	3	4	3	3	4	3	2	0	4	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:23526913G>A	uc003jgo.2	+	11	1898	c.1716G>A	c.(1714-1716)AGG>AGA	p.R572R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	572	C2H2-type 3.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TTCACCAGAGGATACACACAG	0.562										HNSCC(3;0.000094)			63	89					0	0	0	0	A	23526913	A	A	23526913	2	1	276	1	0	0	0	0	0	0	0	1	12525	1165	41	2		2	PRDM9	5	23526913	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3933	23526913	157388347	494	50383											
ADAMTS12	81792	broad.mit.edu	37	chr5	33684050	33684050	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcggccaccaccagtgtctCcacccatctctccttgctga	6	10	7	18	1	2	1	0	1	2	0	6	1	3	1	6	1	1	1	6	1	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:33684050C>T	uc003jia.1	-	4	908	c.745G>A	c.(745-747)GAG>AAG	p.E249K	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E249K	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	249	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						ACCAGTGTCTCCACCCATCTC	0.527										HNSCC(64;0.19)			31	126					0	0	0	0	T	33684050	T	T	33684050	3	4	276	1	0	0	0	0	1	0	0	0	257	864	30	2	4123	2	ADAMTS12	5	33684050	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	10157137	33684050	147231210	495	50384											
NIPBL	25836	broad.mit.edu	37	chr5	36986250	36986250	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagacaaagtagaaaaaataGgattagttgaagatctaaat	22	9	8	2	0	1	4	0	1	1	3	1	5	1	5	0	1	0	2	0	1	11	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:36986250G>A	uc003jkl.3	+	10	3467	c.2968G>A	c.(2968-2970)GGA>AGA	p.G990R	NIPBL_uc003jkk.3_Missense_Mutation_p.G990R|NIPBL_uc003jkm.1_Missense_Mutation_p.G869R	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	990					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AGAAAAAATAGGATTAGTTGA	0.353													34	160					0	0	0	0	A	36986250	A	A	36986250	3	1	276	1	0	0	0	0	1	0	0	0	10482	1001	35	4	3002	4	NIPBL	5	36986250	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3302200	36986250	143929010	496	50385											
LIFR	3977	broad.mit.edu	37	chr5	38482070	38482070	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatcgactgaacatcaatgTaaataacctgtgcagtccct	14	10	6	11	1	1	1	1	1	0	0	3	2	2	1	2	0	3	2	2	0	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:38482070T>G	uc010ive.1	-	20	3253	c.2921A>C	c.(2920-2922)TAC>TCC	p.Y974S	LIFR_uc003jli.2_Missense_Mutation_p.Y974S	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	974	Cytoplasmic (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					AACATCAATGTAAATAACCTG	0.473			T	PLAG1	salivary adenoma								37	134					0	0	0	0	G	38482070	G	G	38482070	3	3	276	1	0	0	0	0	1	0	0	0	8821	1638	57	5	376	5	LIFR	5	38482070	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1495820	38482070	142433190	497	50386											
FYB	2533	broad.mit.edu	37	chr5	39202420	39202420	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgaagacacattcttcatggGgctttcgtcttcatgggagt	8	14	11	8	1	4	2	2	1	2	1	5	3	4	3	0	3	0	1	0	3	1	4	rs138788331	by1000genomes	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:39202420G>A	uc003jls.2	-	1	710	c.643C>T	c.(643-645)CCC>TCC	p.P215S	FYB_uc003jlt.2_Missense_Mutation_p.P215S|FYB_uc003jlu.2_Missense_Mutation_p.P215S|FYB_uc011cpl.1_Missense_Mutation_p.P225S	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	215					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TTCTTCATGGGGCTTTCGTCT	0.527													18	95					0	0	0	0	A	39202420	A	A	39202420	3	1	276	1	0	0	0	0	1	0	0	0	6158	1232	43	4	1918	4	FYB	5	39202420	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	720350	39202420	141712840	498	50387											
HEATR7B2	133558	broad.mit.edu	37	chr5	41018504	41018504	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctctttctctttcccactctTtttgtgaaacaagccacatt	8	17	3	13	0	3	1	0	1	3	0	5	1	4	1	2	0	2	0	2	0	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:41018504T>C	uc003jmj.3	-	27	3192	c.2702A>G	c.(2701-2703)AAA>AGA	p.K901R	HEATR7B2_uc003jmi.3_Missense_Mutation_p.K456R	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	901							binding			ovary(6)|central_nervous_system(2)	8						TTCCCACTCTTTTTGTGAAAC	0.353													5	32					0	0	0	0	C	41018504	C	C	41018504	3	2	276	1	0	0	0	0	1	0	0	0	7074	1841	64	5	2119	5	HEATR7B2	5	41018504	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1816084	41018504	139896756	499	50388											
C6	729	broad.mit.edu	37	chr5	41158837	41158837	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggaatctgcttctatctcaGgaagatcgacctctttcatt	9	14	7	11	2	5	1	2	0	4	1	7	4	5	3	1	2	1	1	1	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:41158837G>A	uc003jmk.2	-	13	2117	c.1907C>T	c.(1906-1908)CCT>CTT	p.P636L	C6_uc003jml.1_Missense_Mutation_p.P636L	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	636					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTCTATCTCAGGAAGATCGAC	0.343													19	35					0	0	0	0	A	41158837	A	A	41158837	3	1	276	1	0	0	0	0	1	0	0	0	2325	1000	35	4	921	4	C6	5	41158837	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	140333	41158837	139756423	500	50389											
C6	729	broad.mit.edu	37	chr5	41161795	41161795	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaataatttttactcttacCtcaaagtcaatcacagcagg	14	12	6	9	0	4	0	3	0	1	0	4	1	4	1	1	2	3	1	1	2	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:41161795C>A	uc003jmk.2	-	10	1668	c.1458G>T	c.(1456-1458)GAG>GAT	p.E486D	C6_uc003jml.1_Missense_Mutation_p.E486D	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	486	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTACTCTTACCTCAAAGTCAA	0.398													23	39					1.64293e-13	1.69094e-13	1	0	A	41161795	A	A	41161795	3	1	276	1	0	0	0	0	1	0	0	0	2325	695	24	4	1382	4	C6	5	41161795	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2958	41161795	139753465	501	50390											
PLCXD3	345557	broad.mit.edu	37	chr5	41313799	41313799	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcaccaagttctacaaaatCggcagtgacaatattgatgc	14	10	8	9	1	2	2	1	2	1	0	3	2	2	2	1	1	2	2	1	1	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:41313799C>T	uc003jmm.1	-	3	988	c.886G>A	c.(886-888)GAT>AAT	p.D296N		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	296					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						TCTACAAAATCGGCAGTGACA	0.448													20	31					0	0	0	0	T	41313799	T	T	41313799	3	4	276	1	0	0	0	0	1	0	0	0	12098	884	31	1	83	1	PLCXD3	5	41313799	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	152004	41313799	139601461	502	50391											
GHR	2690	broad.mit.edu	37	chr5	42719110	42719110	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caccagcaggtagtgtggtcCtttccccgggccaaaagaat	10	8	11	12	1	0	1	0	0	0	1	2	1	2	1	5	3	1	2	5	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:42719110C>T	uc003jmt.2	+	10	1544	c.1501C>T	c.(1501-1503)CTT>TTT	p.L501F	GHR_uc011cpq.1_Missense_Mutation_p.L314F	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	501	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TAGTGTGGTCCTTTCCCCGGG	0.488													19	38					0	0	0	0	T	42719110	T	T	42719110	3	4	276	1	0	0	0	0	1	0	0	0	6408	681	24	4	1535	4	GHR	5	42719110	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1405311	42719110	138196150	503	50392											
EMB	133418	broad.mit.edu	37	chr5	49707071	49707071	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttcctgttgcactgacaaGataattattctcaagttgtt	10	16	7	8	0	1	2	1	1	1	1	3	2	2	2	1	0	1	5	1	0	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:49707071G>A	uc003jom.2	-	3	592	c.343C>T	c.(343-345)CTT>TTT	p.L115F	EMB_uc003jol.2_Missense_Mutation_p.L46F|EMB_uc011cpy.1_Missense_Mutation_p.L65F|EMB_uc010ivr.2_Intron	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	115	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				GCACTGACAAGATAATTATTC	0.348													20	60					0	0	0	0	A	49707071	A	A	49707071	3	1	276	1	0	0	0	0	1	0	0	0	5109	942	33	2	668	2	EMB	5	49707071	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6987961	49707071	131208189	504	50393											
DDX4	54514	broad.mit.edu	37	chr5	55056103	55056103	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggcggaattttggaaacaGaggtaagcatctttgtcttt	10	14	12	5	1	2	1	0	0	2	1	2	3	2	3	0	4	2	2	0	4	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:55056103G>A	uc003jqg.3	+	4	277	c.203G>A	c.(202-204)AGA>AAA	p.R68K	DDX4_uc010ivz.2_Missense_Mutation_p.R68K|DDX4_uc003jqh.3_Missense_Mutation_p.R68K	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	68	Gly-rich.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TTTGGAAACAGAGGTAAGCAT	0.373													19	60					0	0	0	0	A	55056103	A	A	55056103	3	1	276	1	0	0	0	0	1	0	0	0	4377	942	33	2	213	2	DDX4	5	55056103	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5349032	55056103	125859157	505	50394											
IL31RA	133396	broad.mit.edu	37	chr5	55195921	55195921	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ataattctcttgggaagtctCcagtggccaccctgaggatt	9	12	10	10	0	2	1	0	1	2	0	4	3	2	3	3	3	0	0	3	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:55195921C>T	uc003jql.2	+	8	1095	c.1030C>T	c.(1030-1032)CCA>TCA	p.P344S	IL31RA_uc003jqk.2_Missense_Mutation_p.P344S|IL31RA_uc011cqj.1_Missense_Mutation_p.P202S|IL31RA_uc003jqm.2_Missense_Mutation_p.P312S|IL31RA_uc003jqn.2_Missense_Mutation_p.P344S|IL31RA_uc010iwa.1_Missense_Mutation_p.P312S|IL31RA_uc003jqo.2_Missense_Mutation_p.P202S	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	312	Extracellular (Potential).|Fibronectin type-III 3.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				TGGGAAGTCTCCAGTGGCCAC	0.458													35	166					0	0	0	0	T	55195921	T	T	55195921	3	4	276	1	0	0	0	0	1	0	0	0	7730	855	30	2	1060	2	IL31RA	5	55195921	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	139818	55195921	125719339	506	50395											
CRHBP	1393	broad.mit.edu	37	chr5	76264687	76264687	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caaatggaaacagtatcgggGaattctgtttgtctggtctt	10	14	11	6	1	3	0	0	0	3	0	4	2	3	2	0	4	1	2	0	4	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:76264687G>A	uc003ker.2	+	7	1226	c.946G>A	c.(946-948)GAA>AAA	p.E316K		NM_001882	NP_001873	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	316					female pregnancy|learning or memory|signal transduction	soluble fraction					0		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		CAGTATCGGGGAATTCTGTTT	0.433													9	56					0	0	0	0	A	76264687	A	A	76264687	3	1	276	1	0	0	0	0	1	0	0	0	3885	1175	41	2	972	2	CRHBP	5	76264687	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	21068766	76264687	104650573	507	50396											
DMGDH	29958	broad.mit.edu	37	chr5	78325767	78325767	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagagccagtaattaaaaGaaactccccaggagattggt	15	8	9	9	0	0	3	0	0	0	3	2	4	2	3	4	2	2	1	4	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:78325767G>A	uc003kfs.2	-	11	1780	c.1774C>T	c.(1774-1776)CTT>TTT	p.L592F	DMGDH_uc011cte.1_Missense_Mutation_p.L442F|DMGDH_uc011ctf.1_Missense_Mutation_p.L391F|DMGDH_uc011ctg.1_Missense_Mutation_p.L212F	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	592					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		GTAATTAAAAGAAACTCCCCA	0.368													11	29					0	0	0	0	A	78325767	A	A	78325767	3	1	276	1	0	0	0	0	1	0	0	0	4603	942	33	2	850	2	DMGDH	5	78325767	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2061080	78325767	102589493	508	50397											
DMGDH	29958	broad.mit.edu	37	chr5	78338147	78338147	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tagtttctgaccccctgatgGggccccaccataggcagaat	9	9	10	13	0	1	3	0	2	1	1	1	3	1	3	5	3	0	2	5	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:78338147G>A	uc003kfs.2	-	7	1158	c.1152C>T	c.(1150-1152)CCC>CCT	p.P384P	DMGDH_uc011cte.1_Silent_p.P234P|DMGDH_uc011ctf.1_Silent_p.P183P|DMGDH_uc011ctg.1_Intron	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	384					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		CCCCCTGATGGGGCCCCACCA	0.418													11	47					0	0	0	0	A	78338147	A	A	78338147	2	1	276	1	0	0	0	0	0	0	0	1	4603	1219	43	4		4	DMGDH	5	78338147	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	12380	78338147	102577113	509	50398											
JMY	133746	broad.mit.edu	37	chr5	78587049	78587049	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaactccagtatgcagtttCtaaggaaactttgcagatga	15	11	8	7	0	1	2	0	1	1	1	2	3	2	3	1	1	4	4	1	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:78587049C>T	uc003kfx.3	+	4	1974	c.1454C>T	c.(1453-1455)TCT>TTT	p.S485F	JMY_uc003kfw.1_Missense_Mutation_p.S131F	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	485	Interaction with p300/EP300 (By similarity).				'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		TATGCAGTTTCTAAGGAAACT	0.403													24	36					0	0	0	0	T	78587049	T	T	78587049	3	4	276	1	0	0	0	0	1	0	0	0	7996	913	32	2	1468	2	JMY	5	78587049	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	248902	78587049	102328211	510	50399											
JMY	133746	broad.mit.edu	37	chr5	78610464	78610465	+	Missense_Mutation	DNP	CC	TT	TT																															caccaccacctcccccacctCctccccctcccccaccacca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:78610464_78610465CC>TT	uc003kfx.3	+	9	2969_2970	c.2449_2450CC>TT	c.(2449-2451)CCT>TTT	p.P817F	JMY_uc003kfw.1_Missense_Mutation_p.P463F	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	817	Pro-rich.				'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		tcccccacctcctccccctccc	0.347													11	27					0	0	0	0	TT	78610465	TT	TT	78610464	3	4	276	1	0	0	0	0	1	0	0	0	7996	855	30	2	2483	2	JMY	5	78610464	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	23415	78610464	102304796	511	50400											
THBS4	7060	broad.mit.edu	37	chr5	79351645	79351645	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagaacgatgggaaggtgcaTttggtggttttcaacaacct	12	11	12	6	1	1	1	1	0	0	1	1	3	1	2	1	4	4	2	1	4	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:79351645T>A	uc003kgh.2	+	4	653	c.330T>A	c.(328-330)CAT>CAA	p.H110Q		NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	110	TSP N-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GGAAGGTGCATTTGGTGGTTT	0.567													44	193					0	0	0	0	A	79351645	A	A	79351645	3	1	276	1	0	0	0	0	1	0	0	0	15922	1490	52	5	340	5	THBS4	5	79351645	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	741181	79351645	101563615	512	50401											
VCAN	1462	broad.mit.edu	37	chr5	82837304	82837304	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttctcagacaccatcatctCccctcactatctactcaggc	9	11	3	18	0	6	1	4	0	3	1	8	1	6	1	3	1	1	0	3	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:82837304C>T	uc003kii.3	+	8	8838	c.8482C>T	c.(8482-8484)CCC>TCC	p.P2828S	VCAN_uc003kij.3_Missense_Mutation_p.P1841S|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.P1492S	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2828	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACCATCATCTCCCCTCACTAT	0.502													9	66					0	0	0	0	T	82837304	T	T	82837304	3	4	276	1	0	0	0	0	1	0	0	0	17206	855	30	2	8508	2	VCAN	5	82837304	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3485659	82837304	98077956	513	50402											
POLR3G	10622	broad.mit.edu	37	chr5	89802421	89802421	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggaagcaaagagaaaagtaAagaaggtgatgatgacgatg	20	5	14	2	1	0	5	0	3	0	2	0	8	0	6	0	2	1	2	0	2	7	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:89802421A>C	uc003kjq.2	+	7	715	c.515A>C	c.(514-516)AAA>ACA	p.K172T	POLR3G_uc011cuc.1_Missense_Mutation_p.K172T	NM_006467	NP_006458	O15318	RPC7_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	172	Glu-rich.				innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA-directed RNA polymerase activity				0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;2.74e-31)|Epithelial(54;8.2e-26)|all cancers(79;3.86e-22)		gagaaaagtaaagaaggtgat	0.1													10	42					0	0	0	0	C	89802421	C	C	89802421	3	2	276	1	0	0	0	0	1	0	0	0	12289	14	1	5	537	5	POLR3G	5	89802421	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	6965117	89802421	91112839	514	50403											
GPR98	84059	broad.mit.edu	37	chr5	90106814	90106814	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cactgcagaagttcttatccGaagaactggtgggtttactg	10	12	11	8	1	1	2	0	0	1	2	2	3	2	2	1	2	3	3	1	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:90106814G>A	uc003kju.2	+	74	15833	c.15737G>A	c.(15736-15738)CGA>CAA	p.R5246Q	GPR98_uc003kjt.2_Missense_Mutation_p.R2952Q|GPR98_uc003kjw.2_Missense_Mutation_p.R907Q	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5246	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTTCTTATCCGAAGAACTGGT	0.418													12	68					0	0	0	0	A	90106814	A	A	90106814	3	1	276	1	0	0	0	0	1	0	0	0	6760	1058	37	1	16031	1	GPR98	5	90106814	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	304393	90106814	90808446	515	50404											
GPR98	84059	broad.mit.edu	37	chr5	90107097	90107097	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccctcaagggggagcacaGattgtggaggagaaggatga	14	5	16	6	0	1	3	1	1	0	2	1	7	1	6	1	5	2	1	1	5	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:90107097G>A	uc003kju.2	+	74	16116	c.16020G>A	c.(16018-16020)CAG>CAA	p.Q5340Q	GPR98_uc003kjt.2_Silent_p.Q3046Q|GPR98_uc003kjw.2_Silent_p.Q1001Q	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5340	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGGGAGCACAGATTGTGGAGG	0.388													8	20					0	0	0	0	A	90107097	A	A	90107097	2	1	276	1	0	0	0	0	0	0	0	1	6760	933	33	2		2	GPR98	5	90107097	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	283	90107097	90808163	516	50405											
TTC37	9652	broad.mit.edu	37	chr5	94860296	94860296	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcaagagctctctgaaaaCtaagccaccaaagggtaata	16	8	7	10	0	2	2	1	1	2	1	4	2	2	2	2	1	3	2	2	1	7	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:94860296C>T	uc003klb.2	-	16	1596	c.1326_splice	c.e16-1	p.C442_splice	TTC37_uc010jbf.1_Splice_Site_p.C394_splice	NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37								binding			ovary(3)|pancreas(1)	4						TCTCTGAAAACTAAGCCACCA	0.368													8	38					0	0	0	0	T	94860296	T	T	94860296	5	4	276	1	0	0	0	0	0	0	1	0	16773	579	20	4	3481	4	TTC37	5	94860296	Splice_Site	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4753199	94860296	86054964	517	50406											
EPB41L4A	64097	broad.mit.edu	37	chr5	111541182	111541182	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgggtatcagggctattttCattctttgctttcttaaagc	7	19	8	7	0	4	0	2	0	2	0	4	0	4	0	0	2	2	3	0	2	4	9			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:111541182C>T	uc003kpv.1	-	14	1472	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	EPB41L4A_uc003kpp.1_Missense_Mutation_p.E27K	NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	400						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		GGGCTATTTTCATTCTTTGCT	0.308													98	346					0	0	0	0	T	111541182	T	T	111541182	3	4	276	1	0	0	0	0	1	0	0	0	5179	835	29	2	902	2	EPB41L4A	5	111541182	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	16680886	111541182	69374078	518	50407											
FTMT	94033	broad.mit.edu	37	chr5	121188057	121188057	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagaagctgatgaggctgcaGaaccagcgaggaggccggat	12	4	17	8	2	0	4	0	2	0	2	0	8	0	6	2	4	4	3	2	4	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:121188057G>A	uc003kss.2	+	1	408	c.399G>A	c.(397-399)CAG>CAA	p.Q133Q		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	133	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		TGAGGCTGCAGAACCAGCGAG	0.597													14	57					0	0	0	0	A	121188057	A	A	121188057	2	1	276	1	0	0	0	0	0	0	0	1	6119	933	33	2		2	FTMT	5	121188057	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	9646875	121188057	59727203	519	50408											
ADAMTS19	171019	broad.mit.edu	37	chr5	128957966	128957966	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggttccctccaagctgccAgggatgacatacactgctga	10	9	10	12	0	0	2	0	2	0	0	2	3	2	3	3	2	4	3	3	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:128957966A>C	uc003kvb.1	+	10	1677	c.1677A>C	c.(1675-1677)CCA>CCC	p.P559P	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	559	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CCAAGCTGCCAGGGATGACAT	0.468													7	51					0	0	0	0	C	128957966	C	C	128957966	2	2	276	1	0	0	0	0	0	0	0	1	264	175	7	5		5	ADAMTS19	5	128957966	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	7769909	128957966	51957294	520	50409											
FSTL4	23105	broad.mit.edu	37	chr5	132535173	132535173	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcgccccgcactgtgatctCctgcacgtgcagccaggggc	5	7	12	17	3	1	1	0	1	1	0	3	1	1	1	4	2	3	3	4	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:132535173C>T	uc003kyn.1	-	16	2361	c.2143G>A	c.(2143-2145)GAG>AAG	p.E715K	FSTL4_uc003kym.1_Missense_Mutation_p.E364K	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	715						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACTGTGATCTCCTGCACGTGC	0.582													8	58					0	0	0	0	T	132535173	T	T	132535173	3	4	276	1	0	0	0	0	1	0	0	0	6113	864	30	2	389	2	FSTL4	5	132535173	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3577207	132535173	48380087	521	50410											
SEC24A	10802	broad.mit.edu	37	chr5	134002527	134002527	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccataggtccttctgtacctCccttagtgaatccacctctg	7	13	6	15	0	2	1	0	1	2	0	5	1	5	1	6	1	1	1	6	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:134002527C>T	uc003kzs.2	+	3	868	c.580C>T	c.(580-582)CCC>TCC	p.P194S	SEC24A_uc011cxu.1_5'UTR	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	194	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTCTGTACCTCCCTTAGTGAA	0.527													17	93					0	0	0	0	T	134002527	T	T	134002527	3	4	276	1	0	0	0	0	1	0	0	0	14059	855	30	2	590	2	SEC24A	5	134002527	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1467354	134002527	46912733	522	50411											
PITX1	5307	broad.mit.edu	37	chr5	134364547	134364547	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccaaacgacgagtgctgtttGgacttgagccgcaggctggc	8	8	14	11	3	0	1	0	1	0	0	0	4	0	2	2	3	3	4	2	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:134364547G>A	uc010jea.2	-	3	1260	c.867C>T	c.(865-867)TCC>TCT	p.S289S	PITX1_uc011cxy.1_Silent_p.S289S	NM_002653	NP_002644	P78337	PITX1_HUMAN	paired-like homeodomain transcription factor 1	289	Nuclear localization signal (Potential).|OAR.					nucleolus	sequence-specific DNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)		AGTGCTGTTTGGACTTGAGCC	0.602													7	24					0	0	0	0	A	134364547	A	A	134364547	2	1	276	1	0	0	0	0	0	0	0	1	12009	1335	47	4		4	PITX1	5	134364547	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	362020	134364547	46550713	523	50412											
KLHL3	26249	broad.mit.edu	37	chr5	137056259	137056259	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagcctgtatcagagtctggGagctcagcttgacactgtga	9	10	12	10	0	3	3	2	2	1	1	3	4	3	4	1	1	3	3	1	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:137056259G>A	uc010jek.2	-	2	473	c.29C>T	c.(28-30)TCC>TTC	p.S10F	MYOT_uc011cye.1_Intron|KLHL3_uc010jem.1_Intron	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	10						cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		CAGAGTCTGGGAGCTCAGCTT	0.488													12	51					0	0	0	0	A	137056259	A	A	137056259	3	1	276	1	0	0	0	0	1	0	0	0	8422	1174	41	2	1790	2	KLHL3	5	137056259	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2691712	137056259	43859001	524	50413											
WNT8A	7478	broad.mit.edu	37	chr5	137426723	137426723	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagtattactgcgcacgctcCccaggcagtgcccagtccct	8	8	9	16	2	0	0	0	0	0	0	2	0	2	0	4	1	3	4	4	1	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:137426723C>T	uc003lcd.1	+	6	1022	c.1017C>T	c.(1015-1017)TCC>TCT	p.S339S	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_Intron|WNT8A_uc011cyk.1_Silent_p.S357S	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	339					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCGCACGCTCCCCAGGCAGTG	0.517													10	45					0	0	0	0	T	137426723	T	T	137426723	2	4	276	1	0	0	0	0	0	0	0	1	17464	610	22	4		4	WNT8A	5	137426723	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	370464	137426723	43488537	525	50414											
BRD8	10902	broad.mit.edu	37	chr5	137507796	137507796	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggcggccaggttctgcaaaGggcttgattgctctgctaac	7	10	14	10	1	2	1	0	1	2	0	2	1	2	1	1	4	4	5	1	4	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:137507796G>A	uc003lcf.1	-	3	199	c.144C>T	c.(142-144)CCC>CCT	p.P48P	BRD8_uc003lcc.1_RNA|BRD8_uc003lcg.2_Silent_p.P48P|BRD8_uc003lci.2_Silent_p.P48P|BRD8_uc003lch.2_5'UTR|BRD8_uc011cym.1_Silent_p.P32P|BRD8_uc010jer.1_Silent_p.P17P|BRD8_uc011cyn.1_Intron|BRD8_uc010jes.1_Intron	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	48					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GTTCTGCAAAGGGCTTGATTG	0.458													43	83					0	0	0	0	A	137507796	A	A	137507796	2	1	276	1	0	0	0	0	0	0	0	1	1511	987	35	4		4	BRD8	5	137507796	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	81073	137507796	43407464	526	50415											
TMEM173	340061	broad.mit.edu	37	chr5	138858007	138858008	+	Missense_Mutation	DNP	GG	AA	AA																															aggcaccccacagtccaatgGgaggagaatatacagccgct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:138858007_138858008GG>AA	uc003lep.2	-	6	857_858	c.606_607CC>TT	c.(604-609)CTCCCA>CTTTCA	p.P203S		NM_198282	NP_938023	Q86WV6	TM173_HUMAN	transmembrane protein 173	203	Cytoplasmic (Potential).				activation of innate immune response|apoptosis|cellular response to exogenous dsRNA|defense response to virus|innate immune response|interferon-beta production|positive regulation of defense response to virus by host|positive regulation of protein binding|positive regulation of protein import into nucleus, translocation|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane|perinuclear region of cytoplasm|plasma membrane	protein homodimerization activity|protein kinase binding|transcription factor binding			upper_aerodigestive_tract(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CAGTCCAATGGGAGGAGAATAT	0.554													22	136					0	0	0	0	AA	138858008	AA	AA	138858007	3	1	276	1	0	0	0	0	1	0	0	0	16155	1232	43	4	544	4	TMEM173	5	138858007	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	1350211	138858007	42057253	527	50416											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139905595	139905595	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttcagtggagcaagaagttCccatagaacctcctagtgca	12	10	9	10	0	1	2	1	0	0	2	3	3	3	3	3	1	3	3	3	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:139905595C>T	uc003lfs.1	+	26	4631	c.4507C>T	c.(4507-4509)CCC>TCC	p.P1503S	ANKHD1_uc003lfr.2_Missense_Mutation_p.P1503S|ANKHD1_uc003lfu.1_Missense_Mutation_p.P983S|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.P242S|ANKHD1_uc003lfw.2_Missense_Mutation_p.P141S|ANKHD1_uc010jfl.2_5'UTR|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1503						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGAAGTTCCCATAGAACC	0.358													10	53					0	0	0	0	T	139905595	T	T	139905595	3	4	276	1	0	0	0	0	1	0	0	0	629	855	30	2	4609	2	ANKHD1-EIF4EBP3	5	139905595	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1047588	139905595	41009665	528	50417											
PCDHA1	56147	broad.mit.edu	37	chr5	140167698	140167698	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggctacaacgcgtggctgtCctatgaactgcagccggcag	8	7	14	12	3	0	1	0	1	0	0	1	1	1	1	2	3	5	4	2	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140167698C>T	uc003lhb.2	+	1	1823	c.1823C>T	c.(1822-1824)TCC>TTC	p.S608F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.S608F	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	608	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTGGCTGTCCTATGAACTG	0.677													35	46					0	0	0	0	T	140167698	T	T	140167698	3	4	276	1	0	0	0	0	1	0	0	0	11573	855	30	2	1825	2	PCDHA1	5	140167698	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	262103	140167698	40747562	529	50418											
PCDHA2	56146	broad.mit.edu	37	chr5	140176833	140176833	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcagagggtgtgctctgggGaggacccccccaagacggac	8	4	17	12	1	1	2	0	0	1	2	1	5	1	5	3	6	1	2	3	6	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140176833G>A	uc003lhd.2	+	1	2390	c.2284G>A	c.(2284-2286)GAG>AAG	p.E762K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.E762K|PCDHA2_uc011czy.1_Missense_Mutation_p.E762K	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	762	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCTCTGGGGAGGACCCCCC	0.627													7	55					0	0	0	0	A	140176833	A	A	140176833	3	1	276	1	0	0	0	0	1	0	0	0	11578	1175	41	2	2286	2	PCDHA2	5	140176833	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	9135	140176833	40738427	530	50419											
PCDHA4	56144	broad.mit.edu	37	chr5	140186879	140186880	+	Missense_Mutation	DNP	CC	TT	TT																															tcagctccactactcggtctCcgaggaggccaaacacggca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140186879_140186880CC>TT	uc003lhi.2	+	1	208_209	c.107_108CC>TT	c.(106-108)TCC>TTT	p.S36F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.S36F|PCDHA4_uc011daa.1_Missense_Mutation_p.S36F	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	36	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACTCGGTCTCCGAGGAGGCCA	0.663													16	77					0	0	0	0	TT	140186880	TT	TT	140186879	3	4	276	1	0	0	0	0	1	0	0	0	11580	855	30	2	109	2	PCDHA4	5	140186879	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	10046	140186879	40728381	531	50420											
PCDHA4	56144	broad.mit.edu	37	chr5	140187186	140187186	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgttcccagcaacacaaaaGaacctgtccatcgcggaatc	13	7	8	13	2	0	1	0	0	0	1	4	2	2	2	3	1	3	2	3	1	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140187186G>A	uc003lhi.2	+	1	515	c.414G>A	c.(412-414)AAG>AAA	p.K138K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.K138K|PCDHA4_uc011daa.1_Silent_p.K138K	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	138	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACACAAAAGAACCTGTCCA	0.572													36	81					0	0	0	0	A	140187186	A	A	140187186	2	1	276	1	0	0	0	0	0	0	0	1	11580	933	33	2		2	PCDHA4	5	140187186	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	307	140187186	40728074	532	50421											
PCDHA6	56142	broad.mit.edu	37	chr5	140207705	140207705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taccccggaggatagattggGaaagcaatgtctgctcctcc	10	9	11	11	1	1	1	0	0	1	1	3	4	3	4	4	3	3	2	4	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140207705G>A	uc003lho.2	+	1	56	c.29G>A	c.(28-30)GGA>GAA	p.G10E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.G10E|PCDHA6_uc011dab.1_Missense_Mutation_p.G10E	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	10					homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATAGATTGGGAAAGCAATGT	0.512													34	146					0	0	0	0	A	140207705	A	A	140207705	3	1	276	1	0	0	0	0	1	0	0	0	11582	1174	41	2	31	2	PCDHA6	5	140207705	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	20519	140207705	40707555	533	50422											
PCDHA7	56141	broad.mit.edu	37	chr5	140215952	140215952	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagccctcgctgacagccAcagccaccgtgctggtgtcg	6	6	14	15	3	0	1	0	1	0	0	2	2	0	2	4	2	4	2	4	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140215952A>G	uc003lhq.2	+	1	1984	c.1984A>G	c.(1984-1986)ACA>GCA	p.T662A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.T662A	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	662	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGACAGCCACAGCCACCGT	0.657													14	59					0	0	0	0	G	140215952	G	G	140215952	3	3	276	1	0	0	0	0	1	0	0	0	11583	159	6	5	1986	5	PCDHA7	5	140215952	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	8247	140215952	40699308	534	50423											
PCDHA10	56139	broad.mit.edu	37	chr5	140236455	140236455	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcggatgaaggaataaacaaGgaaatgatgtattcatttag	17	11	10	3	1	1	2	1	2	0	0	2	5	1	5	0	3	1	1	0	3	8	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140236455G>A	uc003lhx.2	+	1	822	c.822G>A	c.(820-822)AAG>AAA	p.K274K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.K274K|PCDHA10_uc011dad.1_Silent_p.K274K	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	274	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAATAAACAAGGAAATGATGT	0.363													17	32					0	0	0	0	A	140236455	A	A	140236455	2	1	276	1	0	0	0	0	0	0	0	1	11574	991	35	4		4	PCDHA10	5	140236455	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	20503	140236455	40678805	535	50424											
PCDHA11	56138	broad.mit.edu	37	chr5	140249753	140249753	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcgccgtgacttccttgtcCctcccagtacgagaggacgc	6	9	11	15	4	0	2	0	1	0	1	4	4	3	3	4	1	1	1	4	1	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140249753C>T	uc003lia.2	+	1	1923	c.1065C>T	c.(1063-1065)TCC>TCT	p.S355S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.S355S	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	355	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCCTTGTCCCTCCCAGTAC	0.572													23	38					0	0	0	0	T	140249753	T	T	140249753	2	4	276	1	0	0	0	0	0	0	0	1	11575	610	22	4		4	PCDHA11	5	140249753	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	13298	140249753	40665507	536	50425											
PCDHA12	56137	broad.mit.edu	37	chr5	140256918	140256918	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cggcggtcggcgcgcacatcCcgttccacgtggggctgtac	4	7	15	15	7	0	0	0	0	0	0	3	0	2	0	2	5	1	4	2	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140256918C>T	uc003lic.2	+	1	1988	c.1861C>T	c.(1861-1863)CCG>TCG	p.P621S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.P621S	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	621	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCACATCCCGTTCCACGT	0.672													30	37					0	0	0	0	T	140256918	T	T	140256918	3	4	276	1	0	0	0	0	1	0	0	0	11576	623	22	4	1863	4	PCDHA12	5	140256918	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	7165	140256918	40658342	537	50426											
PCDHA13	56136	broad.mit.edu	37	chr5	140263335	140263335	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgctggtctcctactcgctGgtggagcggcgggtgggcga	3	8	19	11	5	1	0	0	0	1	0	3	2	1	1	1	6	2	2	1	6	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140263335G>A	uc003lif.2	+	1	1482	c.1482G>A	c.(1480-1482)CTG>CTA	p.L494L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.L494L|PCDHA13_uc003lid.2_Silent_p.L494L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	494	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTACTCGCTGGTGGAGCGGC	0.662													20	41					0	0	0	0	A	140263335	A	A	140263335	2	1	276	1	0	0	0	0	0	0	0	1	11577	1335	47	4		4	PCDHA13	5	140263335	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6417	140263335	40651925	538	50427											
PCDHA13	56136	broad.mit.edu	37	chr5	140263918	140263918	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgtcggcaggcgctgtgggtCcagaagcggcgctggtggat	5	7	19	10	5	0	1	0	0	0	1	2	2	1	2	1	6	1	3	1	6	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140263918C>T	uc003lif.2	+	1	2065	c.2065C>T	c.(2065-2067)CCA>TCA	p.P689S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.P689S|PCDHA13_uc003lid.2_Missense_Mutation_p.P689S	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	689	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGTGGGTCCAGAAGCGGC	0.637													19	60					0	0	0	0	T	140263918	T	T	140263918	3	4	276	1	0	0	0	0	1	0	0	0	11577	855	30	2	2067	2	PCDHA13	5	140263918	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	583	140263918	40651342	539	50428											
PCDHAC1	56135	broad.mit.edu	37	chr5	140306562	140306562	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcgagtactcagtgccggagGagacggagcggggcgtagcc	8	5	18	10	5	1	1	1	0	0	1	2	5	1	3	2	5	4	2	2	5	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140306562G>A	uc003lih.2	+	1	261	c.85G>A	c.(85-87)GAG>AAG	p.E29K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.E29K	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	29	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTGCCGGAGGAGACGGAGCG	0.637													6	28					0	0	0	0	A	140306562	A	A	140306562	3	1	276	1	0	0	0	0	1	0	0	0	11586	1175	41	2	87	2	PCDHAC1	5	140306562	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	42644	140306562	40608698	540	50429											
PCDHB2	56133	broad.mit.edu	37	chr5	140475886	140475886	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgcacctgcccctcgcctcCctggtctccatcaacgcgga	5	7	8	21	4	2	0	1	0	1	0	5	1	3	1	7	2	2	1	7	2	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140475886C>T	uc003lil.2	+	1	1650	c.1512C>T	c.(1510-1512)TCC>TCT	p.S504S	PCDHB2_uc003lim.1_Silent_p.S165S	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	504	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTCGCCTCCCTGGTCTCCA	0.687													23	117					0	0	0	0	T	140475886	T	T	140475886	2	4	276	1	0	0	0	0	0	0	0	1	11596	610	22	4		4	PCDHB2	5	140475886	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	169324	140475886	40439374	541	50430											
PCDHB8	56128	broad.mit.edu	37	chr5	140558982	140558982	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccccgccttcacccaaacctCctacaccctgttcgtccgcg	6	8	5	22	4	1	0	1	0	0	0	4	0	3	0	8	0	2	1	8	0	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140558982C>T	uc011dai.1	+	1	1553	c.1367C>T	c.(1366-1368)TCC>TTC	p.S456F	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	456	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCCAAACCTCCTACACCCTG	0.607													53	434					0	0	0	0	T	140558982	T	T	140558982	3	4	276	1	0	0	0	0	1	0	0	0	11602	855	30	2	1369	2	PCDHB8	5	140558982	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	83096	140558982	40356278	542	50431											
PCDHGA2	56113	broad.mit.edu	37	chr5	140719238	140719238	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcatctgcgtgaaggtcctgGatgcgaacgacaatgcgcct	9	8	13	11	4	1	1	0	1	1	0	2	4	2	2	2	2	4	1	2	2	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140719238G>A	uc003ljk.1	+	1	885	c.700G>A	c.(700-702)GAT>AAT	p.D234N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.D234N	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	234	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGGTCCTGGATGCGAACGA	0.597													13	61					0	0	0	0	A	140719238	A	A	140719238	3	1	276	1	0	0	0	0	1	0	0	0	11608	1174	41	2	702	2	PCDHGA2	5	140719238	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	160256	140719238	40196022	543	50432											
PCDHGA3	56112	broad.mit.edu	37	chr5	140723787	140723787	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccgggagctggcggagcgcGgagtccgcatcgtctccaga	6	5	16	14	6	1	1	0	0	1	1	4	4	2	4	3	4	2	2	3	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140723787G>A	uc003ljm.1	+	1	187	c.187G>A	c.(187-189)GGA>AGA	p.G63R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.G63R	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	63	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGGAGCGCGGAGTCCGCAT	0.607											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	146					0	0	0	0	A	140723787	A	A	140723787	3	1	276	1	0	0	0	0	1	0	0	0	11609	1117	39	1	189	1	PCDHGA3	5	140723787	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4549	140723787	40191473	544	50433											
PCDHGB1	56104	broad.mit.edu	37	chr5	140729974	140729974	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacgggtggggaaacttgcCaaggatctggggctcagtgt	8	9	16	8	1	3	0	2	0	1	0	3	2	3	2	1	6	2	1	1	6	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140729974C>A	uc003ljo.1	+	1	147	c.147C>A	c.(145-147)GCC>GCA	p.A49A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Silent_p.A49A	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	49	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAAACTTGCCAAGGATCTGG	0.542											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	30					0.00909568	0.00917528	1	0	A	140729974	A	A	140729974	2	1	276	1	0	0	0	0	0	0	0	1	11616	581	21	4		4	PCDHGB1	5	140729974	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6187	140729974	40185286	545	50434											
PCDHGB2	56103	broad.mit.edu	37	chr5	140740533	140740533	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaggcataaacgcagagatCacctactcctttcataatgt	14	10	7	10	1	2	1	2	0	0	1	3	3	3	1	2	1	2	2	2	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140740533C>T	uc003ljs.1	+	1	831	c.831C>T	c.(829-831)ATC>ATT	p.I277I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Silent_p.I277I	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	277	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCAGAGATCACCTACTCCT	0.468													8	20					0	0	0	0	T	140740533	T	T	140740533	2	4	276	1	0	0	0	0	0	0	0	1	11617	816	29	2		2	PCDHGB2	5	140740533	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	10559	140740533	40174727	546	50435											
PCDHGA6	56109	broad.mit.edu	37	chr5	140755911	140755911	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggctttcctgcagacctattCccacgaggtctcactcactg	7	11	8	15	1	2	1	2	0	1	1	5	2	4	1	3	2	1	2	3	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140755911C>T	uc003ljy.1	+	1	2261	c.2261C>T	c.(2260-2262)TCC>TTC	p.S754F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.S754F	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	754	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGACCTATTCCCACGAGGTC	0.572													11	69					0	0	0	0	T	140755911	T	T	140755911	3	4	276	1	0	0	0	0	1	0	0	0	11612	855	30	2	2263	2	PCDHGA6	5	140755911	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	15378	140755911	40159349	547	50436											
PCDHGA8	9708	broad.mit.edu	37	chr5	140774687	140774687	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgcggaagagtcacctgatCtttccccagcccaactacgc	9	8	8	16	3	2	2	1	1	1	1	4	3	3	3	4	1	3	0	4	1	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140774687C>T	uc003lkd.1	+	1	3205	c.2307C>T	c.(2305-2307)ATC>ATT	p.I769I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Silent_p.I769I	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	769	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCACCTGATCTTTCCCCAGC	0.488													15	74					0	0	0	0	T	140774687	T	T	140774687	2	4	276	1	0	0	0	0	0	0	0	1	11614	903	32	2		2	PCDHGA8	5	140774687	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	18776	140774687	40140573	548	50437											
PCDHGB5	56101	broad.mit.edu	37	chr5	140779294	140779294	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cactacaggcccgcgaccagGgctcgcctgcgctcagcgca	7	4	12	18	5	1	0	1	0	0	0	2	1	1	0	3	2	3	3	3	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140779294G>A	uc003lkf.1	+	1	1600	c.1600G>A	c.(1600-1602)GGC>AGC	p.G534S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.G534S	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	534	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCGACCAGGGCTCGCCTGC	0.677													6	24					0	0	0	0	A	140779294	A	A	140779294	3	1	276	1	0	0	0	0	1	0	0	0	11620	1232	43	4	1602	4	PCDHGB5	5	140779294	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4607	140779294	40135966	549	50438											
PCDHGA9	56107	broad.mit.edu	37	chr5	140783618	140783618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacctcagggaacagtaattCttcttttcaatgctcatgac	11	13	6	11	0	5	1	3	1	2	0	5	2	5	2	1	1	2	2	1	1	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140783618C>T	uc003lkh.1	+	1	1099	c.1099C>T	c.(1099-1101)CTT>TTT	p.L367F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.L367F	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	367	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACAGTAATTCTTCTTTTCAA	0.413													28	25					0	0	0	0	T	140783618	T	T	140783618	3	4	276	1	0	0	0	0	1	0	0	0	11615	913	32	2	1101	2	PCDHGA9	5	140783618	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4324	140783618	40131642	550	50439											
PCDHGA10	56106	broad.mit.edu	37	chr5	140795153	140795153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttagatgattcgaagtttcCtatagaggataccccattgg	11	13	10	7	1	0	3	0	1	0	2	2	5	1	4	3	2	1	2	3	2	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140795153C>T	uc003lkl.1	+	1	2411	c.2411C>T	c.(2410-2412)CCT>CTT	p.P804L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.P804L|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	804	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGAAGTTTCCTATAGAGGAT	0.393													9	52					0	0	0	0	T	140795153	T	T	140795153	3	4	276	1	0	0	0	0	1	0	0	0	11605	681	24	4	2413	4	PCDHGA10	5	140795153	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	11535	140795153	40120107	551	50440											
PCDHGA12	26025	broad.mit.edu	37	chr5	140811010	140811010	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgcacaggcaccgcgcgcatCcgcgtgatggttctggatgc	6	7	14	14	6	1	1	0	1	1	0	2	2	2	2	2	3	1	4	2	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140811010C>T	uc003lkt.1	+	1	853	c.684C>T	c.(682-684)ATC>ATT	p.I228I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Silent_p.I228I	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	228	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCGCGCATCCGCGTGATGG	0.667													11	57					0	0	0	0	T	140811010	T	T	140811010	2	4	276	1	0	0	0	0	0	0	0	1	11607	845	30	2		2	PCDHGA12	5	140811010	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	15857	140811010	40104250	552	50441											
DIAPH1	1729	broad.mit.edu	37	chr5	140953082	140953082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaccagtttggcctccggaGctgcacctctggcttataaa	8	10	11	12	1	1	0	0	0	1	0	2	2	2	2	4	4	2	4	4	4	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:140953082G>A	uc003llb.3	-	16	2476	c.2335C>T	c.(2335-2337)CTC>TTC	p.L779F	DIAPH1_uc003llc.3_Missense_Mutation_p.L770F|DIAPH1_uc010jgc.1_Missense_Mutation_p.L218F	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	779	FH2.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCTCCGGAGCTGCACCTCT	0.398													75	114					0	0	0	0	A	140953082	A	A	140953082	3	1	276	1	0	0	0	0	1	0	0	0	4540	971	34	4	1535	4	DIAPH1	5	140953082	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	142072	140953082	39962178	553	50442											
RBM27	54439	broad.mit.edu	37	chr5	145665539	145665539	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcagatttgtttttgccTgatgatgacgatgaagatga	11	14	10	6	1	1	7	1	5	0	2	1	8	1	7	2	0	1	1	2	0	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:145665539T>C	uc003lnz.3	+	21	3295	c.3129T>C	c.(3127-3129)CCT>CCC	p.P1043P		NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	1043					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGTTTTTGCCTGATGATGACG	0.358													3	74					0	0	0	0	C	145665539	C	C	145665539	2	2	276	1	0	0	0	0	0	0	0	1	13192	1567	55	5		5	RBM27	5	145665539	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	4712457	145665539	35249721	554	50443											
FBXO38	81545	broad.mit.edu	37	chr5	147781995	147781995	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttggggaaatttcgtaatCgtaatggagcttttccaatt	10	17	9	5	2	0	0	0	0	0	0	3	2	1	2	1	3	1	3	1	3	4	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:147781995C>T	uc003lpf.1	+	5	631	c.511C>T	c.(511-513)CGT>TGT	p.R171C	FBXO38_uc003lpg.1_Missense_Mutation_p.R171C|FBXO38_uc003lph.2_Missense_Mutation_p.R171C	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	171						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTCGTAATCGTAATGGAGC	0.358													41	57					0	0	0	0	T	147781995	T	T	147781995	3	4	276	1	0	0	0	0	1	0	0	0	5778	884	31	1	525	1	FBXO38	5	147781995	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2116456	147781995	33133265	555	50444											
AFAP1L1	134265	broad.mit.edu	37	chr5	148712312	148712312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccctggaagctcagtgtcGggcaaaggaggagcgccgga	10	4	16	11	3	1	0	1	0	0	0	2	4	1	4	2	5	2	2	2	5	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:148712312G>A	uc003lqh.2	+	17	2161	c.2030G>A	c.(2029-2031)CGG>CAG	p.R677Q	AFAP1L1_uc010jgy.2_Missense_Mutation_p.R677Q|AFAP1L1_uc003lqi.1_Missense_Mutation_p.R292Q	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	677	Potential.						protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCAGTGTCGGGCAAAGGAG	0.567													32	47					0	0	0	0	A	148712312	A	A	148712312	3	1	276	1	0	0	0	0	1	0	0	0	354	1116	39	1	2096	1	AFAP1L1	5	148712312	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	930317	148712312	32202948	556	50445											
PDGFRB	5159	broad.mit.edu	37	chr5	149500535	149500535	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgaccagcttgccttcacaGatgagcacgttcctagccgc	8	10	9	14	2	1	3	1	2	0	1	2	3	2	3	4	0	4	3	4	0	1	5	rs143375423	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:149500535G>A	uc003lro.2	-	18	2971	c.2502C>T	c.(2500-2502)ATC>ATT	p.I834I	PDGFRB_uc010jhd.2_Silent_p.I673I	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	834	Cytoplasmic (Potential).|Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TGCCTTCACAGATGAGCACGT	0.562			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								18	63					0	0	0	0	A	149500535	A	A	149500535	2	1	276	1	0	0	0	0	0	0	0	1	11716	932	33	2		2	PDGFRB	5	149500535	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	788223	149500535	31414725	557	50446											
PDGFRB	5159	broad.mit.edu	37	chr5	149514449	149514449	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggacaggcagtgcaacgtcCcctttcttctcgtgcagtgt	6	11	12	12	2	2	0	0	0	2	0	4	1	3	1	2	2	3	3	2	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:149514449C>T	uc003lro.2	-	4	964	c.495G>A	c.(493-495)GGG>GGA	p.G165G	PDGFRB_uc010jhd.2_5'UTR|PDGFRB_uc011dcg.1_Silent_p.G165G	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	165	Extracellular (Potential).|Ig-like C2-type 2.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GTGCAACGTCCCCTTTCTTCT	0.507			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								44	98					0	0	0	0	T	149514449	T	T	149514449	2	4	276	1	0	0	0	0	0	0	0	1	11716	610	22	4		4	PDGFRB	5	149514449	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	13914	149514449	31400811	558	50447											
TCOF1	6949	broad.mit.edu	37	chr5	149755775	149755775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaggaactgcgacttctcCagcaggctcatccccagctg	9	7	10	15	1	2	0	1	0	1	0	4	2	3	1	3	2	5	4	3	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:149755775C>T	uc003lry.2	+	13	2132	c.2024C>T	c.(2023-2025)CCA>CTA	p.P675L	TCOF1_uc003lrw.2_Missense_Mutation_p.P675L|TCOF1_uc011dch.1_Missense_Mutation_p.P675L|TCOF1_uc003lrz.2_Missense_Mutation_p.P675L|TCOF1_uc003lrx.2_Missense_Mutation_p.P598L|TCOF1_uc003lsa.2_Missense_Mutation_p.P598L|TCOF1_uc011dci.1_Missense_Mutation_p.P164L	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	675					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCGACTTCTCCAGCAGGCTCA	0.577													43	173					0	0	0	0	T	149755775	T	T	149755775	3	4	276	1	0	0	0	0	1	0	0	0	15774	594	21	4	2074	4	TCOF1	5	149755775	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	241326	149755775	31159485	559	50448											
TCOF1	6949	broad.mit.edu	37	chr5	149772279	149772279	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttctccagtaggtcccaccCcctccaggacagagaccctg	8	7	8	18	0	1	1	0	0	1	1	4	3	3	2	6	2	0	1	6	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:149772279C>T	uc003lry.2	+	22	3634	c.3526C>T	c.(3526-3528)CCC>TCC	p.P1176S	TCOF1_uc011dch.1_Missense_Mutation_p.P1139S|TCOF1_uc003lrz.2_Missense_Mutation_p.P1138S|TCOF1_uc003lrx.2_Missense_Mutation_p.P1100S|TCOF1_uc003lsa.2_Missense_Mutation_p.P1099S	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	1176					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGTCCCACCCCCTCCAGGAC	0.637													4	25					0	0	0	0	T	149772279	T	T	149772279	3	4	276	1	0	0	0	0	1	0	0	0	15774	623	22	4	3637	4	TCOF1	5	149772279	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	16504	149772279	31142981	560	50449											
CD74	972	broad.mit.edu	37	chr5	149786873	149786873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaaagcctgtgtacagggctCcgcggctgcacttgctgtgg	7	9	14	11	2	0	0	0	0	0	0	1	0	1	0	2	3	4	5	2	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:149786873C>T	uc003lsc.2	-	2	151	c.140G>A	c.(139-141)GGA>GAA	p.G47E	CD74_uc003lsb.2_5'Flank|CD74_uc003lse.2_Missense_Mutation_p.G47E|CD74_uc003lsd.2_Missense_Mutation_p.G47E|CD74_uc003lsf.1_Missense_Mutation_p.G47E	NM_001025159	NP_001020330	P04233	HG2A_HUMAN	CD74 antigen isoform a	47	Helical; Signal-anchor for type II membrane protein; (Potential).				antigen processing and presentation of endogenous antigen|cell proliferation|immunoglobulin mediated immune response|intracellular protein transport|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of peptide secretion|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of cytokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of macrophage cytokine production|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|prostaglandin biosynthetic process|protein complex assembly|regulation of macrophage activation	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|lysosome|receptor complex	beta-amyloid binding|cytokine receptor activity|identical protein binding|MHC class II protein binding			breast(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTACAGGGCTCCGCGGCTGCA	0.493			T	ROS1	NSCLC								10	12					0	0	0	0	T	149786873	T	T	149786873	3	4	276	1	0	0	0	0	1	0	0	0	3050	855	30	2	782	2	CD74	5	149786873	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	14594	149786873	31128387	561	50450											
FAT2	2196	broad.mit.edu	37	chr5	150892006	150892006	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagttctctgggaccacaagGgaggtgttgcccatgctgtc	7	10	13	11	0	1	0	0	0	1	0	3	2	1	2	2	3	2	3	2	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:150892006G>A	uc003lue.3	-	20	11638	c.11625C>T	c.(11623-11625)TCC>TCT	p.S3875S	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3875	Extracellular (Potential).|Laminin G-like.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGACCACAAGGGAGGTGTTGC	0.592													40	66					0	0	0	0	A	150892006	A	A	150892006	2	1	276	1	0	0	0	0	0	0	0	1	5722	1219	43	4		4	FAT2	5	150892006	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1105133	150892006	30023254	562	50451											
GLRA1	2741	broad.mit.edu	37	chr5	151235901	151235901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acatgtctggacatccatggGgaaattcttcaagtccatgg	11	11	10	9	0	3	0	1	0	2	0	5	2	5	2	2	4	0	0	2	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:151235901G>A	uc003lut.2	-	5	807	c.520C>T	c.(520-522)CCC>TCC	p.P174S	GLRA1_uc003lur.2_Missense_Mutation_p.P174S|GLRA1_uc003lus.2_Missense_Mutation_p.P91S	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	174	Extracellular (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ACATCCATGGGGAAATTCTTC	0.502													8	49					0	0	0	0	A	151235901	A	A	151235901	3	1	276	1	0	0	0	0	1	0	0	0	6491	1232	43	4	873	4	GLRA1	5	151235901	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	343895	151235901	29679359	563	50452											
GRIA1	2890	broad.mit.edu	37	chr5	153190723	153190723	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatgacttccccaagtccAtgcaatcgattccttgcatg	9	11	7	14	1	0	1	0	1	0	0	4	2	3	1	5	0	2	2	5	0	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:153190723A>G	uc003lva.3	+	16	3024	c.2659A>G	c.(2659-2661)ATG>GTG	p.M887V	GRIA1_uc003luy.3_Missense_Mutation_p.M887V|GRIA1_uc003luz.3_Missense_Mutation_p.M792V|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.M807V|GRIA1_uc011dcx.1_Missense_Mutation_p.M818V|GRIA1_uc011dcy.1_Missense_Mutation_p.M897V|GRIA1_uc011dcz.1_Missense_Mutation_p.M897V	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	887	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CCCCAAGTCCATGCAATCGAT	0.622													24	20					0	0	0	0	G	153190723	G	G	153190723	3	3	276	1	0	0	0	0	1	0	0	0	6806	217	8	5	2840	5	GRIA1	5	153190723	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1954822	153190723	27724537	564	50453											
HAVCR2	84868	broad.mit.edu	37	chr5	156533648	156533648	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccactcacctggtttgatGaccaacttcaggttaaattt	10	14	7	10	0	2	2	2	2	0	0	3	2	3	2	3	2	1	2	3	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:156533648G>A	uc003lwk.1	-	2	528	c.384C>T	c.(382-384)GTC>GTT	p.V128V	HAVCR2_uc003lwl.2_Silent_p.V128V	NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	128	Extracellular (Potential).					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTGGTTTGATGACCAACTTCA	0.403													17	47					0	0	0	0	A	156533648	A	A	156533648	2	1	276	1	0	0	0	0	0	0	0	1	7013	1277	45	2		2	HAVCR2	5	156533648	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3342925	156533648	24381612	565	50454											
SOX30	11063	broad.mit.edu	37	chr5	157065262	157065262	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atgggaagtagtgaggtccgGgtaggaagtaagggtgatga	12	8	19	2	1	0	3	0	3	0	0	1	5	1	5	1	5	0	3	1	5	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:157065262G>A	uc003lxb.1	-	4	2198	c.1856C>T	c.(1855-1857)CCC>CTC	p.P619L	SOX30_uc003lxc.1_Intron|SOX30_uc011dds.1_Missense_Mutation_p.P314L	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	619	Pro-rich.				regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGAGGTCCGGGTAGGAAGTA	0.433													15	30					0	0	0	0	A	157065262	A	A	157065262	3	1	276	1	0	0	0	0	1	0	0	0	15016	1232	43	4	413	4	SOX30	5	157065262	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	531614	157065262	23849998	566	50455											
ATP10B	23120	broad.mit.edu	37	chr5	160033861	160033861	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggagcggcagcacaggacgGaccgacaatactgggtcaat	12	5	14	10	3	1	0	1	0	0	0	1	4	1	3	1	5	3	2	1	5	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:160033861G>A	uc003lym.1	-	19	3918	c.3071C>T	c.(3070-3072)TCC>TTC	p.S1024F	ATP10B_uc010jit.1_Missense_Mutation_p.S341F	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1024	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCACAGGACGGACCGACAATA	0.507													11	86					0	0	0	0	A	160033861	A	A	160033861	3	1	276	1	0	0	0	0	1	0	0	0	1119	1174	41	2	1346	2	ATP10B	5	160033861	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2968599	160033861	20881399	567	50456											
GABRA6	2559	broad.mit.edu	37	chr5	161113294	161113294	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttctactcagaaaacgtcAgtcggatcctggacaacttg	12	10	8	11	2	3	1	2	0	1	1	5	3	4	3	1	2	3	0	1	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:161113294A>C	uc003lyu.2	+	2	435	c.97A>C	c.(97-99)AGT>CGT	p.S33R		NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	33	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGAAAACGTCAGTCGGATCCT	0.483										TCGA Ovarian(5;0.080)			19	64					0	0	0	0	C	161113294	C	C	161113294	3	2	276	1	0	0	0	0	1	0	0	0	6199	188	7	5	103	5	GABRA6	5	161113294	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1079433	161113294	19801966	568	50457											
WWC1	23286	broad.mit.edu	37	chr5	167812284	167812284	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacatatgctgaaggattacCtggtggtggcccaggaggct	10	9	14	8	0	0	1	0	1	0	0	0	3	0	3	2	6	3	2	2	6	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:167812284C>T	uc003lzu.2	+	3	391	c.298C>T	c.(298-300)CTG>TTG	p.L100L	WWC1_uc003lzv.2_Silent_p.L100L|WWC1_uc011den.1_Silent_p.L100L	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	100					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GAAGGATTACCTGGTGGTGGC	0.552													10	55					0	0	0	0	T	167812284	T	T	167812284	2	4	276	1	0	0	0	0	0	0	0	1	17479	680	24	4		4	WWC1	5	167812284	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6698990	167812284	13102976	569	50458											
FAF2	23197	broad.mit.edu	37	chr5	175933836	175933836	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcagattgaagccaattttcCcaggcgagtgctgccctgca	9	10	10	12	1	1	2	1	1	0	1	2	3	2	2	3	1	4	2	3	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:175933836C>T	uc003mej.3	+	11	1276	c.1223C>T	c.(1222-1224)CCC>CTC	p.P408L		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	408	UBX.				response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						GCCAATTTTCCCAGGCGAGTG	0.502													86	132					0	0	0	0	T	175933836	T	T	175933836	3	4	276	1	0	0	0	0	1	0	0	0	5398	623	22	4	1265	4	FAF2	5	175933836	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	8121552	175933836	4981424	570	50459											
ZFP2	80108	broad.mit.edu	37	chr5	178359013	178359013	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgaatttgacagttcatcaGagaactcatacaggagaaaa	18	9	8	6	0	3	4	3	2	0	2	3	6	3	4	0	1	2	1	0	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:178359013G>A	uc003mjn.1	+	5	1208	c.699G>A	c.(697-699)CAG>CAA	p.Q233Q	ZFP2_uc010jky.2_Silent_p.Q233Q|ZFP2_uc010jkx.1_Silent_p.Q233Q	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	233	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		CAGTTCATCAGAGAACTCATA	0.378													14	60					0	0	0	0	A	178359013	A	A	178359013	2	1	276	1	0	0	0	0	0	0	0	1	17708	933	33	2		2	ZFP2	5	178359013	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2425177	178359013	2556247	571	50460											
GRM6	2916	broad.mit.edu	37	chr5	178413884	178413884	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcccactgcctggtacccGccactgctggcactgccatt	5	9	10	17	1	0	0	0	0	0	0	0	0	0	0	5	3	4	3	5	3	1	2	rs149519053	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:178413884G>A	uc003mjr.2	-	7	1634	c.1455C>T	c.(1453-1455)GGC>GGT	p.G485G	GRM6_uc003mjq.2_5'Flank|GRM6_uc010jla.1_Silent_p.G68G|GRM6_uc003mjs.1_Silent_p.G105G	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	485	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane		p.G485G(1)		lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CCTGGTACCCGCCACTGCTGG	0.647													3	28					0	0	0	0	A	178413884	A	A	178413884	2	1	276	1	0	0	0	0	0	0	0	1	6840	1074	38	1		1	GRM6	5	178413884	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	54871	178413884	2501376	572	50461											
OR2V2	285659	broad.mit.edu	37	chr5	180582348	180582348	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acccacttcactatcccatcCtcatgaatcagagggtctgt	10	11	6	14	0	4	2	3	1	1	1	6	2	6	2	3	1	0	0	3	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr5:180582348C>T	uc011dhj.1	+	1	406	c.406C>T	c.(406-408)CTC>TTC	p.L136F		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTATCCCATCCTCATGAATCA	0.512													41	64					0	0	0	0	T	180582348	T	T	180582348	3	4	276	1	0	0	0	0	1	0	0	0	11085	681	24	4	408	4	OR2V2	5	180582348	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2168464	180582348	332912	573	50462											
FAM136B	387071	broad.mit.edu	37	chr6	3046027	3046027	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggaggctgtcttatccattgGgaaataaaagtctttgccag	11	12	11	7	0	2	0	0	0	2	0	3	2	3	2	2	3	1	1	2	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:3046027G>A	uc011dhr.1	+	1	410	c.410G>A	c.(409-411)GGG>GAG	p.G137E		NM_001012983	NP_001013001			hypothetical protein LOC387071												0	Ovarian(93;0.0386)	all_hematologic(90;0.108)				TTATCCATTGGGAAATAAAAG	0.403													14	19					0	0	0	0	A	3046027	A	A	3046027	3	1	276	1	0	0	0	0	1	0	0	0	5479	1232	43	4	412	4	FAM136B	6	3046027	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08		3046027	168069040	574	50463											
LY86	9450	broad.mit.edu	37	chr6	6589096	6589096	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcttggaagtgctctaccaGagttgcggtaagcccttgca	8	10	13	10	1	1	1	0	0	1	1	1	2	1	2	2	3	5	5	2	3	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:6589096G>A	uc003mwy.1	+	1	163	c.129G>A	c.(127-129)CAG>CAA	p.Q43Q	LOC285780_uc003mww.3_Intron|LOC285780_uc003mwx.2_Intron	NM_004271	NP_004262	O95711	LY86_HUMAN	MD-1, RP105-associated precursor	43					apoptosis|cell proliferation|humoral immune response|inflammatory response|innate immune response	extracellular space|plasma membrane					0	Ovarian(93;0.0377)					TGCTCTACCAGAGTTGCGGTA	0.582													15	50					0	0	0	0	A	6589096	A	A	6589096	2	1	276	1	0	0	0	0	0	0	0	1	9151	933	33	2		2	LY86	6	6589096	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3543069	6589096	164525971	575	50464											
PHACTR1	221692	broad.mit.edu	37	chr6	12719057	12719057	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgagtcagctcaaagattCttctacagtcaaggagctca	12	11	9	9	0	6	2	4	1	2	1	6	3	6	3	0	1	3	3	0	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:12719057C>T	uc010jpc.2	+	3	413	c.81C>T	c.(79-81)TTC>TTT	p.F27F	PHACTR1_uc011dir.1_Silent_p.F27F|PHACTR1_uc003nag.1_Silent_p.F27F|PHACTR1_uc003nah.1_Silent_p.F27F|PHACTR1_uc003nai.2_Silent_p.F27F	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	27						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CTCAAAGATTCTTCTACAGTC	0.383													4	5					0	0	0	0	T	12719057	T	T	12719057	2	4	276	1	0	0	0	0	0	0	0	1	11864	912	32	2		2	PHACTR1	6	12719057	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6129961	12719057	158396010	576	50465											
NUP153	9972	broad.mit.edu	37	chr6	17675207	17675207	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	accgtatgttgtttttccagGataaaaaggagaatctccaa	14	12	8	7	1	1	1	0	0	1	1	3	3	2	2	3	2	0	3	3	2	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:17675207G>A	uc003ncd.1	-	5	981	c.781C>T	c.(781-783)CCT>TCT	p.P261S	NUP153_uc011dje.1_Missense_Mutation_p.P261S|NUP153_uc010jpl.1_Missense_Mutation_p.P261S	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	261					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GTTTTTCCAGGATAAAAAGGA	0.383													35	50					0	0	0	0	A	17675207	A	A	17675207	3	1	276	1	0	0	0	0	1	0	0	0	10809	1174	41	2	3718	2	NUP153	6	17675207	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4956150	17675207	153439860	577	50466											
MBOAT1	154141	broad.mit.edu	37	chr6	20109910	20109910	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccagctgagtgacggccCaggtgcctgcatcatacaca	10	6	11	14	1	1	2	1	2	0	0	1	2	1	2	3	2	5	2	3	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:20109910C>A	uc003ncx.1	-	12	1485	c.1280G>T	c.(1279-1281)TGG>TTG	p.W427L	MBOAT1_uc011dji.1_Missense_Mutation_p.W278L	NM_001080480	NP_001073949	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain	427	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			AGTGACGGCCCAGGTGCCTGC	0.498													26	98					1.64293e-13	1.69094e-13	1	0	A	20109910	A	A	20109910	3	1	276	1	0	0	0	0	1	0	0	0	9409	595	21	4	215	4	MBOAT1	6	20109910	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2434703	20109910	151005157	578	50467											
KIAA0319	9856	broad.mit.edu	37	chr6	24596343	24596343	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccctcgctgcccggcagtaGgccccagtccgtgtactcgg	4	7	12	18	4	0	0	0	0	0	0	3	0	1	0	6	3	2	4	6	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:24596343G>A	uc011djo.1	-	3	796	c.559C>T	c.(559-561)CTA>TTA	p.L187L	KIAA0319_uc011djp.1_Silent_p.L142L|KIAA0319_uc003neh.1_Silent_p.L187L|KIAA0319_uc011djq.1_Silent_p.L178L|KIAA0319_uc011djr.1_Silent_p.L187L	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	187	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CCCGGCAGTAGGCCCCAGTCC	0.617													7	28					0	0	0	0	A	24596343	A	A	24596343	2	1	276	1	0	0	0	0	0	0	0	1	8207	991	35	4		4	KIAA0319	6	24596343	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4486433	24596343	146518724	579	50468											
GMNN	51053	broad.mit.edu	37	chr6	24781768	24781768	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	taacatctacaacttccagcCctggggttattgtcccagaa	11	11	7	12	0	1	1	0	0	1	1	3	1	3	1	3	2	4	1	3	2	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:24781768C>T	uc003nem.2	+	4	400	c.193C>T	c.(193-195)CCT>TCT	p.P65S	GMNN_uc003nen.2_Missense_Mutation_p.P65S	NM_015895	NP_056979	O75496	GEMI_HUMAN	geminin	65					M/G1 transition of mitotic cell cycle|negative regulation of cell cycle|negative regulation of DNA replication|negative regulation of transcription, DNA-dependent	cytosol|nucleoplasm	histone deacetylase binding			ovary(1)	1						AACTTCCAGCCCTGGGGTTAT	0.373													10	42					0	0	0	0	T	24781768	T	T	24781768	3	4	276	1	0	0	0	0	1	0	0	0	6530	623	22	4	203	4	GMNN	6	24781768	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	185425	24781768	146333299	580	50469											
FAM65B	9750	broad.mit.edu	37	chr6	24843658	24843659	+	Missense_Mutation	DNP	GG	AA	AA																															ctggatttgttgagttggaaGgggagcctgttgagtgggag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:24843658_24843659GG>AA	uc003neo.1	-	14	1527_1528	c.1351_1352CC>TT	c.(1351-1353)CCT>TTT	p.P451F	FAM65B_uc011djs.1_Missense_Mutation_p.P430F|FAM65B_uc011dju.1_Missense_Mutation_p.P435F|FAM65B_uc003nep.2_Missense_Mutation_p.P401F|FAM65B_uc011djt.1_Missense_Mutation_p.P401F	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	451					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						TGAGTTGGAAGGGGAGCCTGTT	0.55													10	53					0	0	0	0	AA	24843659	AA	AA	24843658	3	1	276	1	0	0	0	0	1	0	0	0	5632	1000	35	4	1904	4	FAM65B	6	24843658	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	61890	24843658	146271409	581	50470											
LRRC16A	55604	broad.mit.edu	37	chr6	25551232	25551233	+	Missense_Mutation	DNP	CC	TT	TT																															agacttgattcatgccagcaCcgaaaagatttctattccac																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:25551232_25551233CC>TT	uc011djw.1	+	27	2799_2800	c.2423_2424CC>TT	c.(2422-2424)ACC>ATT	p.T808I	LRRC16A_uc010jpx.2_Missense_Mutation_p.T808I|LRRC16A_uc010jpy.2_Missense_Mutation_p.T808I|LRRC16A_uc003nfa.1_Missense_Mutation_p.T162I	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	808					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						CATGCCAGCACCGAAAAGATTT	0.391													55	89					0	0	0	0	TT	25551233	TT	TT	25551232	3	4	276	1	0	0	0	0	1	0	0	0	9021	507	18	4	2529	4	LRRC16A	6	25551232	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	707574	25551232	145563835	582	50471											
SLC17A3	10786	broad.mit.edu	37	chr6	25850331	25850331	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctaaactttttggttagaagGaaatctgccagatagcctcc	12	12	8	9	0	1	2	0	0	1	2	2	3	2	3	3	2	3	1	3	2	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:25850331G>A	uc003nfi.3	-	8	944	c.834C>T	c.(832-834)TTC>TTT	p.F278F	SLC17A3_uc003nfk.3_Silent_p.F356F|SLC17A3_uc011djz.1_3'UTR	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	278					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						TGGTTAGAAGGAAATCTGCCA	0.398													11	53					0	0	0	0	A	25850331	A	A	25850331	2	1	276	1	0	0	0	0	0	0	0	1	14483	1165	41	2		2	SLC17A3	6	25850331	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	299099	25850331	145264736	583	50472											
HIST1H1A	3024	broad.mit.edu	37	chr6	26017611	26017611	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcgccgggcttggtttccAcggaggacgccttcttgttg	4	11	15	11	4	1	0	0	0	1	0	2	2	2	2	3	5	0	3	3	5	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:26017611A>G	uc003nfo.2	-	1	430	c.350T>C	c.(349-351)GTG>GCG	p.V117A		NM_005325	NP_005316	Q02539	H11_HUMAN	histone cluster 1, H1a	117					nucleosome assembly|spermatogenesis	nucleosome|nucleus	DNA binding			ovary(2)	2						CTTGGTTTCCACGGAGGACGC	0.542													16	90					0	0	0	0	G	26017611	G	G	26017611	3	3	276	1	0	0	0	0	1	0	0	0	7161	159	6	5	301	5	HIST1H1A	6	26017611	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	167280	26017611	145097456	584	50473											
HIST1H3C	8352	broad.mit.edu	37	chr6	26045858	26045858	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgttccagcgcctggtgcgaGaaatcgcccaggacttcaaa	10	7	11	13	4	1	1	1	0	0	1	3	3	2	2	3	2	2	1	3	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:26045858G>A	uc003nfv.2	+	1	220	c.220G>A	c.(220-222)GAA>AAA	p.E74K	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	74					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						CCTGGTGCGAGAAATCGCCCA	0.627													23	30					0	0	0	0	A	26045858	A	A	26045858	3	1	276	1	0	0	0	0	1	0	0	0	7196	943	33	2	222	2	HIST1H3C	6	26045858	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	28247	26045858	145069209	585	50474											
HIST1H3D	8351	broad.mit.edu	37	chr6	26197348	26197348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgcgcagagccaccgtgccgGgccggtaacggtggggcttc	5	5	17	14	6	0	1	0	0	0	1	1	1	0	1	4	5	3	3	4	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:26197348G>A	uc003ngv.2	-	2	528	c.131C>T	c.(130-132)CCC>CTC	p.P44L	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	44					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				CACCGTGCCGGGCCGGTAACG	0.657													5	59					0	0	0	0	A	26197348	A	A	26197348	3	1	276	1	0	0	0	0	1	0	0	0	7197	1232	43	4	283	4	HIST1H3D	6	26197348	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	151490	26197348	144917719	586	50475											
HIST1H2AM	8336	broad.mit.edu	37	chr6	27860564	27860564	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttagctttgtggtggctctCagtcttcttggggagcagta	5	15	13	8	0	3	0	1	0	3	0	4	1	3	1	0	4	2	4	0	4	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:27860564C>T	uc003nkb.1	-	1	400	c.364G>A	c.(364-366)GAG>AAG	p.E122K	HIST1H3J_uc003nka.2_5'Flank|HIST1H2BO_uc003nkc.1_5'Flank	NM_003514	NP_003505	P0C0S8	H2A1_HUMAN	histone cluster 1, H2am	122					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			ovary(2)	2						TGGTGGCTCTCAGTCTTCTTG	0.498													23	90					0	0	0	0	T	27860564	T	T	27860564	3	4	276	1	0	0	0	0	1	0	0	0	7178	835	29	2	32	2	HIST1H2AM	6	27860564	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1663216	27860564	143254503	587	50476											
SCAND3	114821	broad.mit.edu	37	chr6	28543596	28543596	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taagtaataccgtattttatCtgtttccccatttacagcct	10	17	4	10	1	1	0	0	0	1	0	2	0	2	0	4	0	3	3	4	0	6	9			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:28543596C>T	uc003nlo.2	-	3	1504	c.886G>A	c.(886-888)GAT>AAT	p.D296N		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	296					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CGTATTTTATCTGTTTCCCCA	0.408													27	150					0	0	0	0	T	28543596	T	T	28543596	3	4	276	1	0	0	0	0	1	0	0	0	13941	913	32	2	3099	2	SCAND3	6	28543596	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	683032	28543596	142571471	588	50477											
MAS1L	116511	broad.mit.edu	37	chr6	29454573	29454574	+	Missense_Mutation	DNP	GG	AA	AA																															acatcgaccctgtgctccctGggaagaaggttctccacatg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:29454573_29454574GG>AA	uc011dlq.1	-	1	1106_1107	c.1106_1107CC>TT	c.(1105-1107)CCC>CTT	p.P369L		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	369	Cytoplasmic (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						TGTGCTCCCTGGGAAGAAGGTT	0.515													20	81					0	0	0	0	AA	29454574	AA	AA	29454573	3	1	276	1	0	0	0	0	1	0	0	0	9374	1335	47	4	31	4	MAS1L	6	29454573	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	910977	29454573	141660494	589	50478											
OR2H2	7932	broad.mit.edu	37	chr6	29556101	29556102	+	Missense_Mutation	DNP	CC	TT	TT																															ctacgtggctgtctgccagcCcctccactatgccaccatca																								rs137936888		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:29556101_29556102CC>TT	uc003nmr.1	+	1	419_420	c.380_381CC>TT	c.(379-381)CCC>CTT	p.P127L	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	127	Cytoplasmic (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTCTGCCAGCCCCTCCACTATG	0.579													12	82					0	0	0	0	TT	29556102	TT	TT	29556101	3	4	276	1	0	0	0	0	1	0	0	0	11056	623	22	4	382	4	OR2H2	6	29556101	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	101528	29556101	141558966	590	50479											
ABCF1	23	broad.mit.edu	37	chr6	30554047	30554047	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgcttcacttttccagaccCcccaccactcagccctccag	7	8	5	21	1	2	1	2	0	0	1	4	1	4	1	7	0	1	1	7	0	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:30554047C>T	uc003nql.2	+	18	1945	c.1850C>T	c.(1849-1851)CCC>CTC	p.P617L	ABCF1_uc003nqm.2_Missense_Mutation_p.P579L|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	617					inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						TTTCCAGACCCCCCACCACTC	0.582													10	50					0	0	0	0	T	30554047	T	T	30554047	3	4	276	1	0	0	0	0	1	0	0	0	65	623	22	4	1920	4	ABCF1	6	30554047	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	997946	30554047	140561020	591	50480											
DHX16	8449	broad.mit.edu	37	chr6	30627339	30627339	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcagcaccaggagctcccgGattttggagcccaggcggcg	7	5	16	13	3	0	0	0	0	0	0	1	3	1	3	3	6	3	3	3	6	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:30627339G>A	uc003nqz.2	-	12	2129	c.1917C>T	c.(1915-1917)ATC>ATT	p.I639I	DHX16_uc003nqy.2_Silent_p.I158I|DHX16_uc011dmo.1_Silent_p.I579I	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	639	Helicase C-terminal.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						GGAGCTCCCGGATTTTGGAGC	0.612													8	14					0	0	0	0	A	30627339	A	A	30627339	2	1	276	1	0	0	0	0	0	0	0	1	4524	1164	41	2		2	DHX16	6	30627339	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	73292	30627339	140487728	592	50481											
DDR1	780	broad.mit.edu	37	chr6	30862381	30862381	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccaggtcctagagagccaccCccgtaccaggagccccggcc	8	3	11	19	2	0	1	0	0	0	1	1	3	1	2	9	3	3	1	9	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:30862381C>T	uc003nrr.2	+	12	1705	c.1446C>T	c.(1444-1446)CCC>CCT	p.P482P	DDR1_uc010jse.2_Silent_p.P482P|DDR1_uc003nrq.2_Silent_p.P482P|DDR1_uc003nrs.2_Silent_p.P482P|DDR1_uc003nrt.2_Silent_p.P482P|DDR1_uc011dms.1_Silent_p.P500P|DDR1_uc003nru.2_Silent_p.P482P|DDR1_uc003nrv.2_Silent_p.P482P|DDR1_uc003nrw.1_Missense_Mutation_p.P254L|DDR1_uc003nry.1_RNA|DDR1_uc003nrx.1_RNA|DDR1_uc003nrz.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	482	PPxY motif.|Cytoplasmic (Potential).|Gly/Pro-rich.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	GAGAGCCACCCCCGTACCAGG	0.622													31	58					0	0	0	0	T	30862381	T	T	30862381	2	4	276	1	0	0	0	0	0	0	0	1	4353	610	22	4		4	DDR1	6	30862381	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	235042	30862381	140252686	593	50482											
C6orf15	29113	broad.mit.edu	37	chr6	31079247	31079247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agggcggaggactccaggagGaaatgggttattgatacctg	11	8	16	6	1	0	1	0	1	0	0	1	5	1	5	2	6	1	1	2	6	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:31079247G>A	uc003nsk.1	-	2	889	c.889C>T	c.(889-891)CCT>TCT	p.P297S		NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	297	Pro-rich.										0						ACTCCAGGAGGAAATGGGTTA	0.522													18	51					0	0	0	0	A	31079247	A	A	31079247	3	1	276	1	0	0	0	0	1	0	0	0	2346	1174	41	2	92	2	C6orf15	6	31079247	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	216866	31079247	140035820	594	50483											
HLA-B	3106	broad.mit.edu	37	chr6	31324148	31324148	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttgccgtcgtaggcgtactGgtcatgcccgcggaggaggc	5	8	16	12	5	1	0	1	0	0	0	2	2	1	2	2	5	3	2	2	5	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:31324148G>A	uc003nth.2	-	3	469	c.415C>T	c.(415-417)CAG>TAG	p.Q139*	HLA-C_uc003ntb.2_5'Flank|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_5'Flank|HLA-B_uc011dnk.1_5'Flank|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Nonsense_Mutation_p.Q18*|HLA-B_uc003nti.1_5'Flank|HLA-B_uc010jsn.1_5'Flank|HLA-B_uc010jso.2_Nonsense_Mutation_p.Q111*	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	139	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						TAGGCGTACTGGTCATGCCCG	0.701									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				4	8					0	0	0	0	A	31324148	A	A	31324148	4	1	276	1	0	0	0	0	0	1	0	0	7235	1357	47	4	693	4	HLA-B	6	31324148	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	244901	31324148	139790919	595	50484											
NEU1	4758	broad.mit.edu	37	chr6	31829148	31829148	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actactcctgtctcaacatcGctcactactgccccaaggtt	9	11	5	16	1	2	0	2	0	1	0	5	0	3	0	3	1	4	2	3	1	4	3	rs114405905	by1000genomes	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:31829148G>A	uc003nxq.3	-	3	588	c.432C>T	c.(430-432)AGC>AGT	p.S144S	NEU1_uc010jtg.2_RNA|NEU1_uc003nxr.3_RNA|NEU1_uc010jth.2_5'UTR|NEU1_uc003nxs.3_Silent_p.S144S	NM_000434	NP_000425	Q99519	NEUR1_HUMAN	neuraminidase precursor	144						cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			ovary(1)	1					Oseltamivir(DB00198)|Zanamivir(DB00558)	TCTCAACATCGCTCACTACTG	0.507													11	38					0	0	0	0	A	31829148	A	A	31829148	2	1	276	1	0	0	0	0	0	0	0	1	10395	1078	38	1		1	NEU1	6	31829148	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	505000	31829148	139285919	596	50485											
EHMT2	10919	broad.mit.edu	37	chr6	31864272	31864272	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccccttgctgggggaagagGggaatgactttgtggcatgg	7	9	17	8	0	0	2	0	1	0	1	0	4	0	4	2	6	1	2	2	6	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:31864272G>A	uc003nxz.1	-	4	360	c.350C>T	c.(349-351)CCC>CTC	p.P117L	EHMT2_uc003nxy.1_5'UTR|EHMT2_uc011don.1_Missense_Mutation_p.P174L|EHMT2_uc003nya.1_Missense_Mutation_p.P117L|EHMT2_uc003nyb.1_Missense_Mutation_p.P117L|C2_uc003nyc.2_5'Flank|C2_uc011doo.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	117					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GGGGGAAGAGGGGAATGACTT	0.537													23	101					0	0	0	0	A	31864272	A	A	31864272	3	1	276	1	0	0	0	0	1	0	0	0	5006	1232	43	4	3382	4	EHMT2	6	31864272	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	35124	31864272	139250795	597	50486											
CFB	629	broad.mit.edu	37	chr6	31919771	31919771	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagtgctgccctggctgaaGgagaaactccaagatgagga	13	6	13	9	0	0	4	0	2	0	2	1	6	1	5	2	3	3	2	2	3	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:31919771G>A	uc003nyj.3	+	18	2537	c.2259G>A	c.(2257-2259)AAG>AAA	p.K753K	CFB_uc011dor.1_Silent_p.K1255K	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	753	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						CCTGGCTGAAGGAGAAACTCC	0.502													44	242					0	0	0	0	A	31919771	A	A	31919771	2	1	276	1	0	0	0	0	0	0	0	1	3293	991	35	4		4	CFB	6	31919771	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	55499	31919771	139195296	598	50487											
TNXB	7148	broad.mit.edu	37	chr6	32021380	32021380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccatccaggacaggctgaggGagtcaggggtggcatctgtc	8	7	16	10	0	2	1	1	1	1	0	4	3	3	3	2	6	0	2	2	6	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:32021380G>A	uc003nzl.2	-	25	8772	c.8570C>T	c.(8569-8571)TCC>TTC	p.S2857F		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2906	Fibronectin type-III 21.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CAGGCTGAGGGAGTCAGGGGT	0.652													39	36					0	0	0	0	A	32021380	A	A	32021380	3	1	276	1	0	0	0	0	1	0	0	0	16412	1174	41	2	6223	2	TNXB	6	32021380	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	101609	32021380	139093687	599	50488											
TNXB	7148	broad.mit.edu	37	chr6	32024532	32024532	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccattcctgtactggaccagGaagtggtcaaactggccctc	9	9	10	13	0	1	0	1	0	0	0	3	2	2	2	4	4	2	1	4	4	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:32024532G>A	uc003nzl.2	-	23	8176	c.7974C>T	c.(7972-7974)TTC>TTT	p.F2658F		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2718	Fibronectin type-III 19.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACTGGACCAGGAAGTGGTCAA	0.647													24	35					0	0	0	0	A	32024532	A	A	32024532	2	1	276	1	0	0	0	0	0	0	0	1	16412	1165	41	2		2	TNXB	6	32024532	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3152	32024532	139090535	600	50489											
COL11A2	1302	broad.mit.edu	37	chr6	33156965	33156965	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agaaatctttgggaaatcctCctagtaaccgagagagatac	15	9	9	8	1	1	3	0	0	1	3	3	6	3	4	3	1	2	1	3	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:33156965C>T	uc003ocx.1	-	3	461	c.233G>A	c.(232-234)GGA>GAA	p.G78E	COL11A2_uc003ocy.1_Missense_Mutation_p.G78E|COL11A2_uc003ocz.1_Missense_Mutation_p.G78E|COL11A2_uc003oda.2_Missense_Mutation_p.G78E	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	78	TSP N-terminal.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GGGAAATCCTCCTAGTAACCG	0.572													5	18					0	0	0	0	T	33156965	T	T	33156965	3	4	276	1	0	0	0	0	1	0	0	0	3683	869	30	2	5308	2	COL11A2	6	33156965	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1132433	33156965	137958102	601	50490											
VPS52	6293	broad.mit.edu	37	chr6	33232176	33232176	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggggccgagtatccaaccccCctaggcgctgggggtcagtg	6	6	16	13	2	1	0	1	0	0	0	2	1	2	0	5	5	1	2	5	5	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:33232176C>T	uc003odm.1	-	14	1709	c.1499G>A	c.(1498-1500)GGG>GAG	p.G500E	VPS52_uc003odn.1_Missense_Mutation_p.G311E	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	500					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						ATCCAACCCCCCTAGGCGCTG	0.562													11	86					0	0	0	0	T	33232176	T	T	33232176	3	4	276	1	0	0	0	0	1	0	0	0	17282	623	22	4	700	4	VPS52	6	33232176	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	75211	33232176	137882891	602	50491											
ZBTB22	9278	broad.mit.edu	37	chr6	33283298	33283298	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaccaacgctacccggcaCacccaggctccccaccgacg	9	2	7	23	4	0	0	0	0	0	0	1	1	1	0	7	2	2	3	7	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:33283298C>A	uc003oeb.2	-	2	1548	c.1396G>T	c.(1396-1398)GTG>TTG	p.V466L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.V466L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTACCCGGCACACCCAGGCTC	0.622													31	173					1.62565e-12	1.66909e-12	1	0	A	33283298	A	A	33283298	3	1	276	1	0	0	0	0	1	0	0	0	17597	478	17	4	512	4	ZBTB22	6	33283298	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	51122	33283298	137831769	603	50492											
ZBTB22	9278	broad.mit.edu	37	chr6	33283441	33283441	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggttgccctgcatgtccaagGgaaggagcggtcgaggaggg	8	6	19	8	2	0	0	0	0	0	0	2	4	1	3	2	6	3	2	2	6	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:33283441G>A	uc003oeb.2	-	2	1405	c.1253C>T	c.(1252-1254)CCC>CTC	p.P418L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.P418L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATGTCCAAGGGAAGGAGCGG	0.617													39	133					0	0	0	0	A	33283441	A	A	33283441	3	1	276	1	0	0	0	0	1	0	0	0	17597	1232	43	4	655	4	ZBTB22	6	33283441	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	143	33283441	137831626	604	50493											
ZBTB22	9278	broad.mit.edu	37	chr6	33284361	33284361	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaggcggccagtgtaagcGgaggctaggacagtctcaaa	11	6	15	9	2	1	1	1	1	1	0	2	3	1	3	1	5	1	2	1	5	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:33284361G>A	uc003oeb.2	-	2	485	c.333C>T	c.(331-333)TCC>TCT	p.S111S	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.S111S	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	111	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAGTGTAAGCGGAGGCTAGGA	0.557													29	84					0	0	0	0	A	33284361	A	A	33284361	2	1	276	1	0	0	0	0	0	0	0	1	17597	1103	39	1		1	ZBTB22	6	33284361	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	920	33284361	137830706	605	50494											
SYNGAP1	8831	broad.mit.edu	37	chr6	33391298	33391298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaacccaatacgttcattccCcgtatgatcgtcctggttgg	8	12	9	12	3	1	1	1	1	0	0	4	2	3	1	4	2	2	3	4	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:33391298C>T	uc011dri.1	+	2	307	c.112C>T	c.(112-114)CCG>TCG	p.P38S	SYNGAP1_uc003oeo.1_Missense_Mutation_p.P23S|SYNGAP1_uc010juy.2_Missense_Mutation_p.P23S	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	38					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CGTTCATTCCCCGTATGATCG	0.542													38	177					0	0	0	0	T	33391298	T	T	33391298	3	4	276	1	0	0	0	0	1	0	0	0	15513	623	22	4	118	4	SYNGAP1	6	33391298	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	106937	33391298	137723769	606	50495											
ITPR3	3710	broad.mit.edu	37	chr6	33659606	33659606	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gagctggacagcacagagcgGgcctgtgacactctgttgat	9	8	14	10	1	1	3	0	2	1	1	1	5	1	4	1	2	3	3	1	2	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:33659606G>A	uc011drk.1	+	54	7578	c.7359G>A	c.(7357-7359)CGG>CGA	p.R2453R	ITPR3_uc003oey.2_Silent_p.R540R	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2453	Extracellular (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GCACAGAGCGGGCCTGTGACA	0.612													31	112					0	0	0	0	A	33659606	A	A	33659606	2	1	276	1	0	0	0	0	0	0	0	1	7961	1219	43	4		4	ITPR3	6	33659606	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	268308	33659606	137455461	607	50496											
IP6K3	117283	broad.mit.edu	37	chr6	33693272	33693272	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaggtgctctgcgcacacttCctcatgtggcgggccttctt	4	12	12	13	2	3	0	1	0	2	0	4	1	4	0	2	3	2	2	2	3	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:33693272C>T	uc010jvf.2	-	6	1247	c.711G>A	c.(709-711)AGG>AGA	p.R237R	IP6K3_uc003ofb.2_Silent_p.R237R	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	237					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						GCGCACACTTCCTCATGTGGC	0.637													4	19					0	0	0	0	T	33693272	T	T	33693272	2	4	276	1	0	0	0	0	0	0	0	1	7829	854	30	2		2	IP6K3	6	33693272	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	33666	33693272	137421795	608	50497											
PACSIN1	29993	broad.mit.edu	37	chr6	34497235	34497235	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaagctggccatgacacGggagatgaacagcaagacgg	15	3	15	8	2	0	4	0	2	0	2	0	6	0	5	1	4	3	2	1	4	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:34497235G>A	uc003ojo.2	+	5	724	c.518G>A	c.(517-519)CGG>CAG	p.R173Q	PACSIN1_uc003ojp.2_Missense_Mutation_p.R173Q	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	173					endocytosis		protein kinase activity				0						GCCATGACACGGGAGATGAAC	0.537													8	44					0	0	0	0	A	34497235	A	A	34497235	3	1	276	1	0	0	0	0	1	0	0	0	11428	1116	39	1	532	1	PACSIN1	6	34497235	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	803963	34497235	136617832	609	50498											
C6orf81	221481	broad.mit.edu	37	chr6	35706178	35706178	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggcctctgcttgtactacGgatgacatcgtgttgctggg	6	12	13	10	2	1	1	0	1	1	0	2	2	1	2	1	3	4	4	1	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:35706178G>A	uc003ola.2	+	3	435	c.408G>A	c.(406-408)ACG>ACA	p.T136T	LOC285847_uc010jvy.1_5'Flank|C6orf81_uc003olb.1_Silent_p.T109T	NM_145028	NP_659465	Q5T9G4	CF081_HUMAN	hypothetical protein LOC221481	109	ARM 1.						binding			ovary(1)	1						CTTGTACTACGGATGACATCG	0.522													17	56					0	0	0	0	A	35706178	A	A	35706178	2	1	276	1	0	0	0	0	0	0	0	1	2382	1103	39	1		1	C6orf81	6	35706178	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1208943	35706178	135408889	610	50499											
BRPF3	27154	broad.mit.edu	37	chr6	36181743	36181743	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagaatcccccccggagcccCctactctgaaacccattaat	12	7	5	17	1	1	2	0	1	1	1	2	3	2	3	6	1	3	0	6	1	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:36181743C>T	uc003olv.3	+	8	2793	c.2569C>T	c.(2569-2571)CCT>TCT	p.P857S	BRPF3_uc010jwb.2_Intron|BRPF3_uc011dtj.1_Intron|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Intron	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	857					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CCCGGAGCCCCCTACTCTGAA	0.512													24	77					0	0	0	0	T	36181743	T	T	36181743	3	4	276	1	0	0	0	0	1	0	0	0	1526	623	22	4	2595	4	BRPF3	6	36181743	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	475565	36181743	134933324	611	50500											
PNPLA1	285848	broad.mit.edu	37	chr6	36275453	36275453	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccagaaaaggcttcccaaGacattcgggatccaaaaaac	17	5	7	12	1	0	2	0	0	0	2	3	3	2	3	3	2	1	1	3	2	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:36275453G>A	uc010jwf.2	+	8	1559	c.1559G>A	c.(1558-1560)AGA>AAA	p.R520K	PNPLA1_uc003olw.1_Missense_Mutation_p.R425K|PNPLA1_uc010jwe.1_Missense_Mutation_p.R434K	NM_001145717	NP_001139189	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	520					lipid catabolic process		hydrolase activity			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4						GGCTTCCCAAGACATTCGGGA	0.473													10	54					0	0	0	0	A	36275453	A	A	36275453	3	1	276	1	0	0	0	0	1	0	0	0	12219	942	33	2	1616	2	PNPLA1	6	36275453	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	93710	36275453	134839614	612	50501											
FGD2	221472	broad.mit.edu	37	chr6	36982748	36982748	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gacccctctaacaccctgctCcgtgagggcccggtcctcaa	7	7	9	18	2	2	1	1	1	1	0	4	2	4	1	6	2	2	1	6	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:36982748C>T	uc010jwp.1	+	8	1134	c.963C>T	c.(961-963)CTC>CTT	p.L321L	FGD2_uc003ong.2_Silent_p.L43L|FGD2_uc011dtv.1_5'UTR|FGD2_uc003oni.1_Silent_p.L127L	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	321	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						ACACCCTGCTCCGTGAGGGCC	0.632													6	32					0	0	0	0	T	36982748	T	T	36982748	2	4	276	1	0	0	0	0	0	0	0	1	5865	842	30	2		2	FGD2	6	36982748	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	707295	36982748	134132319	613	50502											
DNAH8	1769	broad.mit.edu	37	chr6	38790671	38790671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaatttttacccgggggtagCggagcacaaggatatttcta	11	11	12	7	2	1	0	0	0	1	0	1	3	1	2	1	4	3	2	1	4	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:38790671C>T	uc003ooe.1	+	25	3530	c.2930C>T	c.(2929-2931)GCG>GTG	p.A977V		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CCGGGGGTAGCGGAGCACAAG	0.418													4	34					0	0	0	0	T	38790671	T	T	38790671	3	4	276	1	0	0	0	0	1	0	0	0	4629	768	27	1	3020	1	DNAH8	6	38790671	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1807923	38790671	132324396	614	50503											
GLP1R	2740	broad.mit.edu	37	chr6	39047475	39047475	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagctctccttcacctccttCcaggtgacttcatgcttggg	5	13	9	14	0	3	1	2	1	1	0	6	2	5	1	4	2	2	2	4	2	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:39047475C>T	uc003ooj.3	+	11	1239	c.1179C>T	c.(1177-1179)TTC>TTT	p.F393F	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	393	Helical; Name=7; (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	TCACCTCCTTCCAGGTGACTT	0.512													14	47					0	0	0	0	T	39047475	T	T	39047475	2	4	276	1	0	0	0	0	0	0	0	1	6489	854	30	2		2	GLP1R	6	39047475	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	256804	39047475	132067592	615	50504											
DAAM2	23500	broad.mit.edu	37	chr6	39869086	39869086	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcccttgacagttcgccaaGgccttgatgcacttcgggga	7	10	12	12	2	0	2	0	2	0	0	3	3	1	3	3	3	1	2	3	3	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:39869086G>T	uc003oow.2	+	24	2976	c.2820G>T	c.(2818-2820)AAG>AAT	p.K940N	DAAM2_uc003oox.2_Missense_Mutation_p.K939N	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	940	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					AGTTCGCCAAGGCCTTGATGC	0.572													44	155					2.52991e-16	2.61871e-16	1	0	T	39869086	T	T	39869086	3	4	276	1	0	0	0	0	1	0	0	0	4233	991	35	4	2907	4	DAAM2	6	39869086	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	821611	39869086	131245981	616	50505											
PRPH2	5961	broad.mit.edu	37	chr6	42689888	42689888	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cccccatccctatcaatgagTtgggcacaaaatggctctca	11	9	7	14	0	2	1	2	1	1	0	4	1	3	1	3	2	0	3	3	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:42689888T>C	uc003osk.2	-	1	471	c.185A>G	c.(184-186)AAC>AGC	p.N62S		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	62	Helical; (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			TATCAATGAGTTGGGCACAAA	0.507													23	80					0	0	0	0	C	42689888	C	C	42689888	3	2	276	1	0	0	0	0	1	0	0	0	12639	1725	60	5	867	5	PRPH2	6	42689888	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	2820802	42689888	128425179	617	50506											
PTCRA	171558	broad.mit.edu	37	chr6	42890854	42890854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtggtggtctgcctggtcCttgatgttgcaccccctggc	2	13	14	12	0	1	1	0	1	1	0	2	1	2	1	4	5	2	2	4	5	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:42890854C>T	uc003osx.2	+	2	229	c.148C>T	c.(148-150)CTT>TTT	p.L50F	PTCRA_uc011duz.1_Silent_p.S60S|PTCRA_uc010jxx.1_Intron|PTCRA_uc010jxy.2_Intron|PTCRA_uc010jxz.2_Intron	NM_138296	NP_612153	Q6ISU1	PTCRA_HUMAN	pre T-cell antigen receptor alpha precursor	50	Extracellular (Potential).					integral to membrane	receptor activity			ovary(2)	2	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CTGCCTGGTCCTTGATGTTGC	0.602													27	55					0	0	0	0	T	42890854	T	T	42890854	3	4	276	1	0	0	0	0	1	0	0	0	12797	681	24	4	154	4	PTCRA	6	42890854	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	200966	42890854	128224213	618	50507											
ABCC10	89845	broad.mit.edu	37	chr6	43406424	43406424	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcctggccacccaggaacCctggatccagtttgccacca	8	7	10	16	0	0	0	0	0	0	0	1	2	1	2	7	4	2	1	7	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:43406424C>T	uc003ouy.1	+	8	2233	c.2018C>T	c.(2017-2019)CCC>CTC	p.P673L	ABCC10_uc003ouz.1_Missense_Mutation_p.P645L|ABCC10_uc010jyo.1_5'UTR	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	673	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			ACCCAGGAACCCTGGATCCAG	0.582													40	41					0	0	0	0	T	43406424	T	T	43406424	3	4	276	1	0	0	0	0	1	0	0	0	50	623	22	4	1956	4	ABCC10	6	43406424	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	515570	43406424	127708643	619	50508											
C6orf154	221424	broad.mit.edu	37	chr6	43475211	43475211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taccgctggggcacatccagGagctgctgcctctctggtgg	5	9	14	13	1	1	0	0	0	1	0	3	1	2	1	3	5	4	4	3	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:43475211G>A	uc003ovk.1	-	5	1764	c.863C>T	c.(862-864)TCC>TTC	p.S288F	C6orf154_uc003ovj.1_Missense_Mutation_p.S97F	NM_001012974	NP_001012992	Q5JTD7	CF154_HUMAN	hypothetical protein LOC221424	288											0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GCACATCCAGGAGCTGCTGCC	0.637													4	36					0	0	0	0	A	43475211	A	A	43475211	3	1	276	1	0	0	0	0	1	0	0	0	2349	1174	41	2	95	2	C6orf154	6	43475211	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	68787	43475211	127639856	620	50509											
AARS2	57505	broad.mit.edu	37	chr6	44273502	44273502	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcccaggtctccacacagtGacaaggaccaggccacttca	11	6	9	15	0	2	1	1	1	1	0	4	2	3	2	4	3	0	0	4	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:44273502G>C	uc010jza.1	-	10	1325	c.1322C>G	c.(1321-1323)TCA>TGA	p.S441*	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_020745	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	441					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			ovary(1)	1	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	TCCACACAGTGACAAGGACCA	0.542													22	95					0	0	0	0	C	44273502	C	C	44273502	4	2	276	1	0	0	0	0	0	1	0	0	20	1294	45	2	1687	2	AARS2	6	44273502	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	798291	44273502	126841565	621	50510											
SPATS1	221409	broad.mit.edu	37	chr6	44320587	44320587	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtcagtgagcctcctggcctCcccagagtgtctgcttacgt	5	11	11	14	1	2	2	1	1	1	1	4	2	4	2	5	1	3	1	5	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:44320587C>G	uc003oxk.2	+	2	611	c.264C>G	c.(262-264)CTC>CTG	p.L88L	SPATS1_uc003oxg.2_RNA|SPATS1_uc010jzb.2_5'UTR	NM_145026	NP_659463	Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	88										skin(1)	1	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTCCTGGCCTCCCCAGAGTGT	0.498													8	55					0	0	0	0	G	44320587	G	G	44320587	2	3	276	1	0	0	0	0	0	0	0	1	15084	842	30	2		2	SPATS1	6	44320587	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	47085	44320587	126794480	622	50511											
RCAN2	10231	broad.mit.edu	37	chr6	46191013	46191013	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acacttggggtggactcagtCcctgcatggagctcatactt	8	11	11	11	0	2	0	2	0	0	0	3	2	3	2	1	4	3	2	1	4	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:46191013C>T	uc003oyb.1	-	4	774	c.459G>A	c.(457-459)GGG>GGA	p.G153G	RCAN2_uc003oyc.1_Silent_p.G199G|RCAN2_uc003oyd.1_Silent_p.G199G	NM_005822	NP_005813	Q14206	RCAN2_HUMAN	Down syndrome critical region gene 1-like 1	153					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding				0						TGGACTCAGTCCCTGCATGGA	0.498													27	104					0	0	0	0	T	46191013	T	T	46191013	2	4	276	1	0	0	0	0	0	0	0	1	13234	842	30	2		2	RCAN2	6	46191013	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1870426	46191013	124924054	623	50512											
GPR110	266977	broad.mit.edu	37	chr6	46993686	46993686	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atttctcaaatctcttttctCcttggaatctctataggtca	9	18	4	10	0	5	0	2	0	4	0	9	1	5	1	1	2	0	0	1	2	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:46993686C>T	uc003oyt.2	-	4	380	c.181G>A	c.(181-183)GAG>AAG	p.E61K	GPR110_uc011dwl.1_5'UTR|GPR110_uc003oyu.1_Missense_Mutation_p.E61K	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	61	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TCTCTTTTCTCCTTGGAATCT	0.413													20	82					0	0	0	0	T	46993686	T	T	46993686	3	4	276	1	0	0	0	0	1	0	0	0	6665	864	30	2	2649	2	GPR110	6	46993686	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	802673	46993686	124121381	624	50513											
TNFRSF21	27242	broad.mit.edu	37	chr6	47253704	47253704	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggaacataagtggaggaagGgacttcatgggtttccatgt	11	10	15	5	0	1	0	1	0	0	0	2	4	2	4	1	5	1	1	1	5	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:47253704G>A	uc003oyv.2	-	2	1157	c.724C>T	c.(724-726)CCT>TCT	p.P242S		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	242	Extracellular (Potential).				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			GTGGAGGAAGGGACTTCATGG	0.512													5	44					0	0	0	0	A	47253704	A	A	47253704	3	1	276	1	0	0	0	0	1	0	0	0	16361	1232	43	4	1263	4	TNFRSF21	6	47253704	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	260018	47253704	123861363	625	50514											
PKHD1	5314	broad.mit.edu	37	chr6	51944732	51944732	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatctcgtggtcctggatttGgactgcttaccagctgtccc	5	14	10	12	1	1	0	0	0	1	0	4	2	3	2	3	3	3	2	3	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:51944732G>A	uc003pah.1	-	5	632	c.356C>T	c.(355-357)CCA>CTA	p.P119L	PKHD1_uc003pai.2_Missense_Mutation_p.P119L	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	119	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TCCTGGATTTGGACTGCTTAC	0.473													33	166					0	0	0	0	A	51944732	A	A	51944732	3	1	276	1	0	0	0	0	1	0	0	0	12026	1348	47	4	12159	4	PKHD1	6	51944732	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4691028	51944732	119170335	626	50515											
PKHD1	5314	broad.mit.edu	37	chr6	51947307	51947307	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggtgtatctccaattgagagCcattgttggggtaaagaaca	12	11	12	6	0	1	2	0	1	1	2	2	3	1	2	2	3	2	3	2	3	5	5	rs148070358		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:51947307C>T	uc003pah.1	-	4	440	c.164G>A	c.(163-165)GGC>GAC	p.G55D	PKHD1_uc003pai.2_Missense_Mutation_p.G55D	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	55	Extracellular (Potential).|IPT/TIG 1; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CAATTGAGAGCCATTGTTGGG	0.478													11	60					0	0	0	0	T	51947307	T	T	51947307	3	4	276	1	0	0	0	0	1	0	0	0	12026	739	26	4	12355	4	PKHD1	6	51947307	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2575	51947307	119167760	627	50516											
GSTA5	221357	broad.mit.edu	37	chr6	52701147	52701147	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctcaaccattggtacttgCtggaacagcaaactcccatc	12	10	6	13	0	1	0	1	0	1	0	4	1	2	1	2	2	6	3	2	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:52701147C>T	uc003pba.1	-	4	229	c.159G>A	c.(157-159)CAG>CAA	p.Q53Q		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	53	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	TTGGTACTTGCTGGAACAGCA	0.403													26	90					0	0	0	0	T	52701147	T	T	52701147	2	4	276	1	0	0	0	0	0	0	0	1	6873	796	28	4		4	GSTA5	6	52701147	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	753840	52701147	118413920	628	50517											
ICK	22858	broad.mit.edu	37	chr6	52878665	52878665	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggtgggactggcttaataTaaggaggtgggcctgccttt	8	11	15	7	0	0	0	0	0	0	0	0	2	0	2	2	6	1	1	2	6	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:52878665T>A	uc003pbh.2	-	10	1437	c.947A>T	c.(946-948)TAT>TTT	p.Y316F	ICK_uc003pbi.2_Missense_Mutation_p.Y316F	NM_016513	NP_057597	Q9UPZ9	ICK_HUMAN	intestinal cell kinase	316					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			ovary(1)|large_intestine(1)|lung(1)|kidney(1)|central_nervous_system(1)	5	Lung NSC(77;0.103)					TGGCTTAATATAAGGAGGTGG	0.532													13	35					0	0	0	0	A	52878665	A	A	52878665	3	1	276	1	0	0	0	0	1	0	0	0	7523	1406	49	5	975	5	ICK	6	52878665	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	177518	52878665	118236402	629	50518											
HMGCLL1	54511	broad.mit.edu	37	chr6	55381343	55381343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagattaggagtaaggacaGgatagcgaactcctggatat	15	8	13	5	1	0	1	0	0	0	1	1	7	1	5	1	4	2	1	1	4	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:55381343G>A	uc003pcn.2	-	5	605	c.446C>T	c.(445-447)CCT>CTT	p.P149L	HMGCLL1_uc003pco.2_Missense_Mutation_p.P119L|HMGCLL1_uc010jzx.2_Missense_Mutation_p.P20L|HMGCLL1_uc011dxc.1_Intron|HMGCLL1_uc011dxd.1_Intron|HMGCLL1_uc011dxe.1_Intron|HMGCLL1_uc003pcp.2_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	149							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGTAAGGACAGGATAGCGAAC	0.338													37	50					0	0	0	0	A	55381343	A	A	55381343	3	1	276	1	0	0	0	0	1	0	0	0	7269	1000	35	4	690	4	HMGCLL1	6	55381343	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2502678	55381343	115733724	630	50519											
COL21A1	81578	broad.mit.edu	37	chr6	56033060	56033060	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatcttgttctgttactaaGagacgaatttggtgccagcc	10	13	9	9	1	2	1	0	0	2	1	2	3	2	1	2	1	3	2	2	1	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:56033060G>A	uc003pcs.2	-	6	1294	c.1062C>T	c.(1060-1062)CTC>CTT	p.L354L	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Silent_p.L354L|COL21A1_uc003pcu.1_Silent_p.L354L	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	354	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTGTTACTAAGAGACGAATTT	0.358													4	14					0	0	0	0	A	56033060	A	A	56033060	2	1	276	1	0	0	0	0	0	0	0	1	3695	929	33	2		2	COL21A1	6	56033060	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	651717	56033060	115082007	631	50520											
DST	667	broad.mit.edu	37	chr6	56457058	56457058	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgtttgctcgctgtggcCtcacaggcctggagtccagc	6	10	13	12	1	1	0	1	0	0	0	3	1	2	1	3	3	2	3	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:56457058C>T	uc003pdf.2	-	43	6496	c.6468G>A	c.(6466-6468)GAG>GAA	p.E2156E	DST_uc003pcz.3_Silent_p.E1978E|DST_uc011dxj.1_Silent_p.E2007E|DST_uc011dxk.1_Silent_p.E2018E|DST_uc003pcy.3_Silent_p.E1652E|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4064					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCGCTGTGGCCTCACAGGCCT	0.428													3	23					0	0	0	0	T	56457058	T	T	56457058	2	4	276	1	0	0	0	0	0	0	0	1	4805	680	24	4		4	DST	6	56457058	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	423998	56457058	114658009	632	50521											
DST	667	broad.mit.edu	37	chr6	56504804	56504804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttttatgattttctaaatGgctttcaacacttggcaaat	12	18	5	6	0	2	1	1	1	1	0	2	1	2	1	0	2	1	2	0	2	5	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:56504804G>A	uc003pdf.2	-	18	2471	c.2443C>T	c.(2443-2445)CAT>TAT	p.H815Y	DST_uc003pcz.3_Missense_Mutation_p.H637Y|DST_uc011dxj.1_Missense_Mutation_p.H666Y|DST_uc011dxk.1_Missense_Mutation_p.H677Y|DST_uc011dxl.1_Missense_Mutation_p.H666Y|DST_uc003pcy.3_Missense_Mutation_p.H311Y|DST_uc003pdb.2_Missense_Mutation_p.H311Y|DST_uc003pdc.3_Missense_Mutation_p.H311Y|DST_uc003pdd.3_Missense_Mutation_p.H311Y|DST_uc003pde.2_Missense_Mutation_p.H753Y	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	637					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTTCTAAATGGCTTTCAACA	0.313													18	70					0	0	0	0	A	56504804	A	A	56504804	3	1	276	1	0	0	0	0	1	0	0	0	4805	1348	47	4	19544	4	DST	6	56504804	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	47746	56504804	114610263	633	50522											
PRIM2	5558	broad.mit.edu	37	chr6	57398275	57398275	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggaacagacattgcagttCtggaagcaagaatttatcaa	15	11	9	6	0	2	2	1	0	1	2	2	4	2	4	0	2	3	3	0	2	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:57398275C>T	uc003pdx.2	+	10	1065	c.978C>T	c.(976-978)TTC>TTT	p.F326F		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	326					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CATTGCAGTTCTGGAAGCAAG	0.378													21	170					0	0	0	0	T	57398275	T	T	57398275	2	4	276	1	0	0	0	0	0	0	0	1	12553	912	32	2		2	PRIM2	6	57398275	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	893471	57398275	113716792	634	50523											
COL19A1	1310	broad.mit.edu	37	chr6	70881893	70881893	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggggttgccaggattagaagGatttccaggtgtaaaggtaa	12	10	15	4	0	0	1	0	0	0	1	1	3	1	3	2	6	1	3	2	6	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:70881893G>A	uc003pfc.1	+	41	2723	c.2606G>A	c.(2605-2607)GGA>GAA	p.G869E		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	869	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGATTAGAAGGATTTCCAGGT	0.274													10	57					0	0	0	0	A	70881893	A	A	70881893	3	1	276	1	0	0	0	0	1	0	0	0	3691	1174	41	2	2764	2	COL19A1	6	70881893	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	13483618	70881893	100233174	635	50524											
RIMS1	22999	broad.mit.edu	37	chr6	72961047	72961047	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaggcgacatattcatggaGaaagctctagcaaaaagcta	17	7	9	8	1	2	1	1	0	1	1	2	3	2	1	0	2	3	3	0	2	7	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:72961047G>A	uc003pga.2	+	15	2751	c.2674G>A	c.(2674-2676)GAA>AAA	p.E892K	RIMS1_uc011dyb.1_Missense_Mutation_p.E518K|RIMS1_uc003pgc.2_Missense_Mutation_p.E518K|RIMS1_uc010kaq.2_Missense_Mutation_p.E366K|RIMS1_uc011dyc.1_Missense_Mutation_p.E366K|RIMS1_uc010kar.2_Missense_Mutation_p.E285K|RIMS1_uc011dyd.1_Missense_Mutation_p.E351K|RIMS1_uc003pgf.2_Missense_Mutation_p.E109K|RIMS1_uc003pgg.2_Missense_Mutation_p.E109K|RIMS1_uc003pgi.2_Missense_Mutation_p.E109K|RIMS1_uc003pgh.2_Missense_Mutation_p.E109K|RIMS1_uc003pgd.2_Missense_Mutation_p.E109K|RIMS1_uc003pge.2_Missense_Mutation_p.E109K|RIMS1_uc011dye.1_5'Flank|RIMS1_uc003pgb.3_Missense_Mutation_p.E518K|RIMS1_uc010kas.1_Missense_Mutation_p.E351K	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	892					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TATTCATGGAGAAAGCTCTAG	0.383													4	6					0	0	0	0	A	72961047	A	A	72961047	3	1	276	1	0	0	0	0	1	0	0	0	13432	943	33	2	2895	2	RIMS1	6	72961047	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2079154	72961047	98154020	636	50525											
DPPA5	340168	broad.mit.edu	37	chr6	74063936	74063936	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgggatatgtctacgtgccgGgagagttcccatcttatgac	8	11	12	10	3	2	2	0	1	2	1	3	4	3	3	2	2	2	1	2	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:74063936G>A	uc003pgs.1	-	1	18	c.13C>T	c.(13-15)CCG>TCG	p.P5S		NM_001025290	NP_001020461	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	5					multicellular organismal development	cytoplasm	RNA binding				0						CTACGTGCCGGGAGAGTTCCC	0.582													3	24					0	0	0	0	A	74063936	A	A	74063936	3	1	276	1	0	0	0	0	1	0	0	0	4759	1232	43	4	349	4	DPPA5	6	74063936	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1102889	74063936	97051131	637	50526											
EEF1A1	1915	broad.mit.edu	37	chr6	74228094	74228094	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacctgagcagtgaagccagCtgcttccattggtgggtcat	8	11	12	10	0	1	2	1	2	0	0	2	2	2	2	3	2	5	3	3	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:74228094C>T	uc003phi.2	-	5	1049	c.1012G>A	c.(1012-1014)GCT>ACT	p.A338T	EEF1A1_uc003phd.2_Missense_Mutation_p.A63T|EEF1A1_uc003phe.2_Missense_Mutation_p.A328T|EEF1A1_uc003phf.2_Intron|EEF1A1_uc003phg.2_Missense_Mutation_p.A338T|EEF1A1_uc003phh.2_Missense_Mutation_p.A184T|EEF1A1_uc003phj.2_Missense_Mutation_p.A338T|EEF1A1_uc003phk.2_Missense_Mutation_p.A338T|EEF1A1_uc003phl.2_Intron|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	338						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						GTGAAGCCAGCTGCTTCCATT	0.423											OREG0003895	type=REGULATORY REGION|Gene=D16891|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	17	71					0	0	0	0	T	74228094	T	T	74228094	3	4	276	1	0	0	0	0	1	0	0	0	4945	797	28	4	388	4	EEF1A1	6	74228094	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	164158	74228094	96886973	638	50527											
COL12A1	1303	broad.mit.edu	37	chr6	75892813	75892813	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcaattctaaggcagataGactgtgtgagttcaaaagat	14	11	10	6	0	3	4	2	1	1	3	3	4	3	4	0	1	0	3	0	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:75892813G>A	uc003phs.2	-	10	2010	c.1844C>T	c.(1843-1845)TCT>TTT	p.S615F	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_Missense_Mutation_p.S273F	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	615	VWFA 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						AAGGCAGATAGACTGTGTGAG	0.378													16	54					0	0	0	0	A	75892813	A	A	75892813	3	1	276	1	0	0	0	0	1	0	0	0	3684	942	33	2	7575	2	COL12A1	6	75892813	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1664719	75892813	95222254	639	50528											
FILIP1	27145	broad.mit.edu	37	chr6	76023594	76023594	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcttctgtcttcatcaaatCcccttcgaccacttccaatt	9	15	2	15	1	5	0	2	0	3	0	8	1	7	0	4	0	0	0	4	0	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:76023594C>T	uc003pia.2	-	5	2327	c.1954G>A	c.(1954-1956)GAT>AAT	p.D652N	FILIP1_uc003phy.1_Missense_Mutation_p.D652N|FILIP1_uc003phz.2_Missense_Mutation_p.D553N|FILIP1_uc010kbe.2_Missense_Mutation_p.D655N|FILIP1_uc003pib.1_Missense_Mutation_p.D404N	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	652	Potential.									skin(3)|ovary(1)	4						TTCATCAAATCCCCTTCGACC	0.418													59	227					0	0	0	0	T	76023594	T	T	76023594	3	4	276	1	0	0	0	0	1	0	0	0	5926	855	30	2	1695	2	FILIP1	6	76023594	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	130781	76023594	95091473	640	50529											
IMPG1	3617	broad.mit.edu	37	chr6	76744039	76744040	+	Missense_Mutation	DNP	GG	AA	AA																															tttgggtacttgcctgtcagGgaaacttctctgttttattc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:76744039_76744040GG>AA	uc003pik.1	-	4	619_620	c.489_490CC>TT	c.(487-492)TTCCCT>TTTTCT	p.P164S		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	164					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TGCCTGTCAGGGAAACTTCTCT	0.337													12	31					0	0	0	0	AA	76744040	AA	AA	76744039	3	1	276	1	0	0	0	0	1	0	0	0	7767	1232	43	4	1959	4	IMPG1	6	76744039	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	720445	76744039	94371028	641	50530											
IMPG1	3617	broad.mit.edu	37	chr6	76744384	76744384	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggaattgctgaagttttttCcaatgtcaaagaggcagaag	13	11	12	5	0	1	3	1	1	0	2	2	4	2	4	1	2	1	3	1	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:76744384C>T	uc003pik.1	-	3	552	c.422G>A	c.(421-423)GGA>GAA	p.G141E		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	141					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GAAGTTTTTTCCAATGTCAAA	0.507													23	86					0	0	0	0	T	76744384	T	T	76744384	3	4	276	1	0	0	0	0	1	0	0	0	7767	855	30	2	2031	2	IMPG1	6	76744384	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	345	76744384	94370683	642	50531											
TPBG	7162	broad.mit.edu	37	chr6	83075562	83075562	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggttttcctggacaacaatcCctgggtctgcgactgccaca	8	10	10	13	1	1	0	0	0	1	0	3	2	3	1	3	3	3	1	3	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:83075562C>T	uc003pjn.3	+	3	1820	c.884C>T	c.(883-885)CCC>CTC	p.P295L	TPBG_uc010kbj.2_Missense_Mutation_p.P295L|TPBG_uc003pjo.2_Missense_Mutation_p.P295L	NM_006670	NP_006661	Q13641	TPBG_HUMAN	trophoblast glycoprotein precursor	295	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane				central_nervous_system(1)	1		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		GACAACAATCCCTGGGTCTGC	0.552													13	67					0	0	0	0	T	83075562	T	T	83075562	3	4	276	1	0	0	0	0	1	0	0	0	16461	623	22	4	886	4	TPBG	6	83075562	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6331178	83075562	88039505	643	50532											
DOPEY1	23033	broad.mit.edu	37	chr6	83848374	83848374	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgctgtcatctatctttaGtgctcagaaatggcatagtg	9	16	9	7	0	4	1	2	0	2	1	4	1	4	1	0	1	2	3	0	1	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:83848374G>C	uc003pjs.1	+	21	4873	c.4613G>C	c.(4612-4614)AGT>ACT	p.S1538T	DOPEY1_uc011dyy.1_Missense_Mutation_p.S1529T|DOPEY1_uc010kbl.1_Missense_Mutation_p.S1529T|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1538					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TCTATCTTTAGTGCTCAGAAA	0.388													15	55					0	0	0	0	C	83848374	C	C	83848374	3	2	276	1	0	0	0	0	1	0	0	0	4729	1029	36	4	4687	4	DOPEY1	6	83848374	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	772812	83848374	87266693	644	50533											
MRAP2	112609	broad.mit.edu	37	chr6	84765138	84765138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttatgagattggaccagtttCctttgaaggactgaaggctc	10	13	11	7	0	0	3	0	3	0	1	2	6	1	5	2	3	0	2	2	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:84765138C>T	uc003pkg.3	+	2	291	c.101C>T	c.(100-102)TCC>TTC	p.S34F	MRAP2_uc010kbo.2_5'UTR	NM_138409	NP_612418	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	34					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			skin(2)	2						GGACCAGTTTCCTTTGAAGGA	0.373													13	47					0	0	0	0	T	84765138	T	T	84765138	3	4	276	1	0	0	0	0	1	0	0	0	9807	855	30	2	103	2	MRAP2	6	84765138	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	916764	84765138	86349929	645	50534											
ZNF292	23036	broad.mit.edu	37	chr6	87968650	87968650	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattaaaactgctatgaattCtcaaatacttgaggtaaaaa	18	13	5	5	0	1	2	1	2	1	0	2	2	1	2	0	1	3	2	0	1	10	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:87968650C>T	uc003plm.3	+	8	5344	c.5303C>T	c.(5302-5304)TCT>TTT	p.S1768F		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1768					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GCTATGAATTCTCAAATACTT	0.318													8	16					0	0	0	0	T	87968650	T	T	87968650	3	4	276	1	0	0	0	0	1	0	0	0	17893	913	32	2	5333	2	ZNF292	6	87968650	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3203512	87968650	83146417	646	50535											
MDN1	23195	broad.mit.edu	37	chr6	90380682	90380682	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgggcaagcacagagagcaGctttgcagtactacggtgag	11	7	14	9	1	0	2	0	1	0	1	0	3	0	2	0	2	6	6	0	2	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:90380682G>A	uc003pnn.1	-	83	14028	c.13912C>T	c.(13912-13914)CTG>TTG	p.L4638L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4638					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACAGAGAGCAGCTTTGCAGTA	0.532													21	73					0	0	0	0	A	90380682	A	A	90380682	2	1	276	1	0	0	0	0	0	0	0	1	9468	962	34	4		4	MDN1	6	90380682	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2412032	90380682	80734385	647	50536											
MDN1	23195	broad.mit.edu	37	chr6	90398396	90398396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgtgcttctggaacattggGatgctggtagaagtcatagg	9	11	14	7	1	2	1	1	0	1	1	2	3	2	3	1	4	3	3	1	4	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:90398396G>A	uc003pnn.1	-	66	11271	c.11155C>T	c.(11155-11157)CCC>TCC	p.P3719S		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3719					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGAACATTGGGATGCTGGTAG	0.532													17	19					0	0	0	0	A	90398396	A	A	90398396	3	1	276	1	0	0	0	0	1	0	0	0	9468	1174	41	2	5783	2	MDN1	6	90398396	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	17714	90398396	80716671	648	50537											
CASP8AP2	9994	broad.mit.edu	37	chr6	90577717	90577717	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atgaattattgacatctttgCccagacatggaaaggaagct	14	11	9	7	0	1	3	0	2	1	1	1	5	1	5	1	2	2	1	1	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:90577717C>T	uc003pnr.2	+	8	4904	c.4708C>T	c.(4708-4710)CCC>TCC	p.P1570S	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.P1570S|CASP8AP2_uc011dzz.1_Missense_Mutation_p.P1570S	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1570					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		GACATCTTTGCCCAGACATGG	0.388													45	168					0	0	0	0	T	90577717	T	T	90577717	3	4	276	1	0	0	0	0	1	0	0	0	2690	739	26	4	4734	4	CASP8AP2	6	90577717	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	179321	90577717	80537350	649	50538											
C6orf167	253714	broad.mit.edu	37	chr6	97681814	97681814	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatcacaaagtgtcaaacAacagtgaagatacattcgta	19	8	7	7	1	2	2	2	1	0	1	3	3	2	2	0	0	3	1	0	0	7	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:97681814A>C	uc003ppb.2	-	12	1491	c.1225T>G	c.(1225-1227)TGT>GGT	p.C409G	C6orf167_uc011eaf.1_Intron|C6orf167_uc010kcn.1_Missense_Mutation_p.C183G|C6orf167_uc010kco.1_Missense_Mutation_p.C145G	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	409					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		AGTGTCAAACAACAGTGAAGA	0.328													27	87					0	0	0	0	C	97681814	C	C	97681814	3	2	276	1	0	0	0	0	1	0	0	0	2352	130	5	5	2562	5	C6orf167	6	97681814	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	7104097	97681814	73433253	650	50539											
SIM1	6492	broad.mit.edu	37	chr6	100841642	100841642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctgtaggcgcacgatgcgtCgtgctgggagccaggcctat	6	9	15	11	4	1	0	0	0	1	0	2	2	1	1	2	3	3	3	2	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:100841642C>T	uc003pqj.3	-	10	1498	c.1291G>A	c.(1291-1293)GAC>AAC	p.D431N	SIM1_uc010kcu.2_Missense_Mutation_p.D431N	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	431	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CACGATGCGTCGTGCTGGGAG	0.602													18	35					0	0	0	0	T	100841642	T	T	100841642	3	4	276	1	0	0	0	0	1	0	0	0	14388	884	31	1	1017	1	SIM1	6	100841642	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3159828	100841642	70273425	651	50540											
HACE1	57531	broad.mit.edu	37	chr6	105198279	105198279	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacatatgaaagccctgtaaAaaagcattgatctgaggctg	16	9	9	7	0	1	3	0	3	1	0	1	3	1	3	1	1	3	3	1	1	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:105198279A>G	uc003pqu.1	-	20	2557	c.2280T>C	c.(2278-2280)TTT>TTC	p.F760F	HACE1_uc010kcy.1_Silent_p.F242F|HACE1_uc010kcz.1_Silent_p.F545F|HACE1_uc010kcx.1_Silent_p.F169F|HACE1_uc003pqt.1_Silent_p.F413F	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	760	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		AGCCCTGTAAAAAAGCATTGA	0.383													10	36					0	0	0	0	G	105198279	G	G	105198279	2	3	276	1	0	0	0	0	0	0	0	1	6979	11	1	5		5	HACE1	6	105198279	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	4356637	105198279	65916788	652	50541											
HACE1	57531	broad.mit.edu	37	chr6	105224670	105224670	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgactatctcattggacaGaatatcaaaccactcacgca	15	10	5	11	1	3	2	3	1	1	1	4	3	3	3	1	1	1	1	1	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:105224670G>A	uc003pqu.1	-	17	2087	c.1810C>T	c.(1810-1812)CTG>TTG	p.L604L	HACE1_uc010kcy.1_Silent_p.L86L|HACE1_uc010kcz.1_Intron|HACE1_uc010kcx.1_Silent_p.L13L|HACE1_uc003pqt.1_Silent_p.L257L	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	604	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		TCATTGGACAGAATATCAAAC	0.333													10	38					0	0	0	0	A	105224670	A	A	105224670	2	1	276	1	0	0	0	0	0	0	0	1	6979	933	33	2		2	HACE1	6	105224670	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	26391	105224670	65890397	653	50542											
BVES	11149	broad.mit.edu	37	chr6	105563586	105563586	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggacatgctggaggtaccCcgaagaaactggtgcaagcc	12	5	14	10	1	0	1	0	0	0	1	0	5	0	3	3	4	5	3	3	4	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:105563586C>T	uc003pqw.2	-	7	1090	c.933G>A	c.(931-933)CGG>CGA	p.R311R	BVES_uc003pqx.2_Silent_p.R311R|BVES_uc003pqy.2_Silent_p.R311R	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	311	Cytoplasmic (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				TGGAGGTACCCCGAAGAAACT	0.473													16	76					0	0	0	0	T	105563586	T	T	105563586	2	4	276	1	0	0	0	0	0	0	0	1	1580	610	22	4		4	BVES	6	105563586	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	338916	105563586	65551481	654	50543											
PREP	5550	broad.mit.edu	37	chr6	105726198	105726198	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtactgaagggtggcaatgaActtcagggagtgaagcggga	12	7	17	5	1	1	3	1	3	0	0	1	5	1	5	0	4	3	2	0	4	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:105726198A>G	uc003prc.2	-	15	2157	c.1954T>C	c.(1954-1956)TTC>CTC	p.F652L		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	652					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	GTGGCAATGAACTTCAGGGAG	0.468													7	37					0	0	0	0	G	105726198	G	G	105726198	3	3	276	1	0	0	0	0	1	0	0	0	12536	43	2	5	182	5	PREP	6	105726198	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	162612	105726198	65388869	655	50544											
BEND3	57673	broad.mit.edu	37	chr6	107390290	107390290	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggaccaccagctcgtccaagGggatcttgcaaaagtccttg	10	8	11	12	1	1	0	0	0	1	0	4	2	3	2	4	3	2	2	4	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:107390290G>A	uc003prs.2	-	5	2755	c.2105C>T	c.(2104-2106)CCC>CTC	p.P702L		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	702										ovary(3)	3						CTCGTCCAAGGGGATCTTGCA	0.617													10	74					0	0	0	0	A	107390290	A	A	107390290	3	1	276	1	0	0	0	0	1	0	0	0	1401	1232	43	4	385	4	BEND3	6	107390290	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1664092	107390290	63724777	656	50545											
WASF1	8936	broad.mit.edu	37	chr6	110422844	110422844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catcactgattacaggtaggGttgatggatggcgctttggc	8	12	14	7	1	1	2	1	2	0	0	1	3	1	3	0	5	1	3	0	5	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:110422844G>A	uc003ptv.1	-	10	2306	c.1469C>T	c.(1468-1470)ACC>ATC	p.T490I	WASF1_uc003ptw.1_Missense_Mutation_p.T490I|WASF1_uc003ptx.1_Missense_Mutation_p.T490I|WASF1_uc003pty.1_Missense_Mutation_p.T490I	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	490					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		TACAGGTAGGGTTGATGGATG	0.468													32	123					0	0	0	0	A	110422844	A	A	110422844	3	1	276	1	0	0	0	0	1	0	0	0	17320	1261	44	4	218	4	WASF1	6	110422844	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3032554	110422844	60692223	657	50546											
GPRC6A	222545	broad.mit.edu	37	chr6	117128036	117128036	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaacatggaattgcctcaGaaataccacaatgacattaa	20	8	5	8	0	1	2	1	1	0	1	1	3	1	3	2	1	3	0	2	1	7	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:117128036G>A	uc003pxj.1	-	3	854	c.832C>T	c.(832-834)CTG>TTG	p.L278L	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Silent_p.L278L	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	278	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AATTGCCTCAGAAATACCACA	0.353													14	60					0	0	0	0	A	117128036	A	A	117128036	2	1	276	1	0	0	0	0	0	0	0	1	6767	933	33	2		2	GPRC6A	6	117128036	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6705192	117128036	53987031	658	50547											
ROS1	6098	broad.mit.edu	37	chr6	117609777	117609777	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atctttgtctgcatgtggttCcttctcttctttcctcagac	4	19	6	12	0	5	1	1	0	4	1	8	1	7	1	2	1	1	2	2	1	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:117609777C>T	uc003pxp.1	-	43	7121	c.6922G>A	c.(6922-6924)GAA>AAA	p.E2308K	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2308	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCATGTGGTTCCTTCTCTTCT	0.483			T	GOPC|ROS1	glioblastoma|NSCLC								17	60					0	0	0	0	T	117609777	T	T	117609777	3	4	276	1	0	0	0	0	1	0	0	0	13596	864	30	2	125	2	ROS1	6	117609777	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	481741	117609777	53505290	659	50548											
ROS1	6098	broad.mit.edu	37	chr6	117718139	117718139	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggttctctgtgtccctgcatCtaatttttgatttttgctga	5	20	8	8	0	2	2	0	2	2	0	4	2	3	2	1	1	2	3	1	1	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:117718139C>T	uc003pxp.1	-	7	917	c.718G>A	c.(718-720)GAT>AAT	p.D240N	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	240	Fibronectin type-III 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GTCCCTGCATCTAATTTTTGA	0.408			T	GOPC|ROS1	glioblastoma|NSCLC								32	121					0	0	0	0	T	117718139	T	T	117718139	3	4	276	1	0	0	0	0	1	0	0	0	13596	913	32	2	6473	2	ROS1	6	117718139	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	108362	117718139	53396928	660	50549											
SLC35F1	222553	broad.mit.edu	37	chr6	118475784	118475784	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cacactagccgtcagacaagGtaagctcacaaaagcaccag	16	4	8	13	1	2	1	2	0	0	1	2	1	2	1	2	1	3	3	2	1	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:118475784G>A	uc003pxx.3	+	2	550	c.349_splice	c.e2+1	p.G117_splice		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1						transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		GTCAGACAAGGTAAGCTCACA	0.403													29	137					0	0	0	0	A	118475784	A	A	118475784	5	1	276	1	0	0	0	0	0	0	1	0	14652	1275	44	4	356	4	SLC35F1	6	118475784	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	757645	118475784	52639283	661	50550											
THEMIS	387357	broad.mit.edu	37	chr6	128134451	128134451	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtttacagagctcagaaatCgggtactgtttcttatcatg	10	15	9	7	1	3	2	2	0	1	2	4	2	3	2	0	1	3	4	0	1	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:128134451C>T	uc003qbi.2	-	5	1654	c.1335G>A	c.(1333-1335)CCG>CCA	p.P445P	THEMIS_uc010kfa.2_Silent_p.P348P|THEMIS_uc011ebt.1_Silent_p.P445P|THEMIS_uc010kfb.2_Silent_p.P410P	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	445	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						GCTCAGAAATCGGGTACTGTT	0.468													32	115					0	0	0	0	T	128134451	T	T	128134451	2	4	276	1	0	0	0	0	0	0	0	1	15926	871	31	1		1	THEMIS	6	128134451	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	9658667	128134451	42980616	662	50551											
THEMIS	387357	broad.mit.edu	37	chr6	128150863	128150863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagtgagtttgatgattcCttgctactgcacagctcacc	9	13	9	10	0	1	4	1	4	0	0	2	4	2	4	2	0	4	4	2	0	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:128150863C>T	uc003qbi.2	-	4	786	c.467G>A	c.(466-468)AGG>AAG	p.R156K	THEMIS_uc010kfa.2_Missense_Mutation_p.R59K|THEMIS_uc011ebt.1_Missense_Mutation_p.R156K|THEMIS_uc010kfb.2_Missense_Mutation_p.R121K	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	156	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TTGATGATTCCTTGCTACTGC	0.378													14	109					0	0	0	0	T	128150863	T	T	128150863	3	4	276	1	0	0	0	0	1	0	0	0	15926	681	24	4	1595	4	THEMIS	6	128150863	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	16412	128150863	42964204	663	50552											
PTPRK	5796	broad.mit.edu	37	chr6	128411004	128411004	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttgctctcgttgtgaccacgGaagtaatggtagcagatagt	10	12	12	7	2	1	2	0	1	1	1	2	3	1	3	1	2	2	5	1	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:128411004G>A	uc003qbk.2	-	8	1663	c.1296C>T	c.(1294-1296)TTC>TTT	p.F432F	PTPRK_uc003qbj.2_Silent_p.F432F|PTPRK_uc010kfc.2_Silent_p.F432F|PTPRK_uc011ebu.1_Silent_p.F432F|PTPRK_uc003qbl.1_Silent_p.F302F|PTPRK_uc011ebv.1_Silent_p.F432F	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	432	Extracellular (Potential).|Fibronectin type-III 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TGTGACCACGGAAGTAATGGT	0.483													16	66					0	0	0	0	A	128411004	A	A	128411004	2	1	276	1	0	0	0	0	0	0	0	1	12870	1165	41	2		2	PTPRK	6	128411004	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	260141	128411004	42704063	664	50553											
LAMA2	3908	broad.mit.edu	37	chr6	129634086	129634086	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcaactgtcatccaaaattCtctggtgcaaaatgtacaga	14	11	7	9	0	2	1	1	0	1	1	4	1	3	1	1	1	4	3	1	1	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:129634086C>T	uc003qbn.2	+	23	3360	c.3255C>T	c.(3253-3255)TTC>TTT	p.F1085F	LAMA2_uc003qbo.2_Silent_p.F1085F	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1085	Laminin EGF-like 12.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATCCAAAATTCTCTGGTGCAA	0.473													5	36					0	0	0	0	T	129634086	T	T	129634086	2	4	276	1	0	0	0	0	0	0	0	1	8646	912	32	2		2	LAMA2	6	129634086	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1223082	129634086	41480981	665	50554											
LAMA2	3908	broad.mit.edu	37	chr6	129802480	129802480	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgccaattgatgtaggaacaGaaatcaacctgtcattcagc	14	10	8	9	0	3	2	3	1	0	1	3	3	3	3	2	1	4	1	2	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:129802480G>A	uc003qbn.2	+	54	7750	c.7645G>A	c.(7645-7647)GAA>AAA	p.E2549K	LAMA2_uc003qbo.2_Missense_Mutation_p.E2545K|uc003qbq.2_RNA	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2549	Laminin G-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGTAGGAACAGAAATCAACCT	0.463													26	95					0	0	0	0	A	129802480	A	A	129802480	3	1	276	1	0	0	0	0	1	0	0	0	8646	943	33	2	7863	2	LAMA2	6	129802480	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	168394	129802480	41312587	666	50555											
EPB41L2	2037	broad.mit.edu	37	chr6	131211548	131211548	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgggtgcggccactatagcGaaatttggaccccaaggtca	10	9	12	10	2	1	0	1	0	0	0	1	2	1	1	3	4	2	0	3	4	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:131211548G>A	uc003qch.2	-	11	1728	c.1546C>T	c.(1546-1548)CGC>TGC	p.R516C	EPB41L2_uc003qcg.1_Missense_Mutation_p.R516C|EPB41L2_uc011eby.1_Missense_Mutation_p.R516C|EPB41L2_uc003qci.2_Missense_Mutation_p.R516C|EPB41L2_uc010kfk.2_Missense_Mutation_p.R516C|EPB41L2_uc010kfl.1_Missense_Mutation_p.R516C	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	516	Hydrophilic.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CCACTATAGCGAAATTTGGAC	0.517													54	76					0	0	0	0	A	131211548	A	A	131211548	3	1	276	1	0	0	0	0	1	0	0	0	5177	1058	37	1	1507	1	EPB41L2	6	131211548	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1409068	131211548	39903519	667	50556											
CTAGE9	643854	broad.mit.edu	37	chr6	132029995	132029995	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gttcctggaggaggtgggggGaaaggaggtcctcttctcat	7	10	17	7	0	2	0	1	0	2	0	5	4	4	4	2	8	0	1	2	8	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:132029995G>A	uc011ece.1	-	1	2163	c.2163C>T	c.(2161-2163)TTC>TTT	p.F721F	ENPP3_uc003qcu.3_Intron|ENPP3_uc010kfq.2_Intron|ENPP3_uc003qcv.2_Intron	NM_001145659	NP_001139131	A4FU28	CTGE9_HUMAN	CTAGE family, member 4-like	721	Pro-rich.					integral to membrane					0						GAGGTGGGGGGAAAGGAGGTC	0.522													44	142					0	0	0	0	A	132029995	A	A	132029995	2	1	276	1	0	0	0	0	0	0	0	1	4013	1165	41	2		2	CTAGE9	6	132029995	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	818447	132029995	39085072	668	50557											
VNN1	8876	broad.mit.edu	37	chr6	133014449	133014449	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgattttcacccatgaaaagGttttgctgcaataaacagaa	15	12	7	7	0	1	3	1	2	0	1	1	3	1	3	1	1	3	3	1	1	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:133014449G>A	uc003qdo.2	-	4	560	c.540C>T	c.(538-540)AAC>AAT	p.N180N		NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	180	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		CCATGAAAAGGTTTTGCTGCA	0.363													8	32					0	0	0	0	A	133014449	A	A	133014449	2	1	276	1	0	0	0	0	0	0	0	1	17250	1252	44	4		4	VNN1	6	133014449	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	984454	133014449	38100618	669	50558											
AHI1	54806	broad.mit.edu	37	chr6	135811762	135811762	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaatgatcatttacttactGagatgttttcttcagacctg	10	16	6	9	0	3	3	2	2	1	2	3	4	3	3	2	0	2	1	2	0	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:135811762G>A	uc003qgi.2	-	5	518	c.134C>T	c.(133-135)TCA>TTA	p.S45L	AHI1_uc003qgh.2_Missense_Mutation_p.S45L|AHI1_uc003qgj.2_Missense_Mutation_p.S45L|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Missense_Mutation_p.S45L	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	45	Potential.					adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TTTACTTACTGAGATGTTTTC	0.318													29	140					0	0	0	0	A	135811762	A	A	135811762	3	1	276	1	0	0	0	0	1	0	0	0	413	1304	45	2	3613	2	AHI1	6	135811762	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2797313	135811762	35303305	670	50559											
TNFAIP3	7128	broad.mit.edu	37	chr6	138202171	138202171	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgcctgttctttccactcaGagatcgagccagcgcagaga	9	9	10	13	2	2	2	1	0	1	2	4	5	3	2	3	0	3	2	3	0	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:138202171G>A	uc003qhr.2	+	9	2155	c.2089_splice	c.e9-1	p.R697_splice	TNFAIP3_uc003qhs.2_Splice_Site_p.R697_splice	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3						anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		TTTCCACTCAGAGATCGAGCC	0.522			D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								18	63					0	0	0	0	A	138202171	A	A	138202171	5	1	276	1	0	0	0	0	0	0	1	0	16340	956	33	2	2118	2	TNFAIP3	6	138202171	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2390409	138202171	32912896	671	50560											
NMBR	4829	broad.mit.edu	37	chr6	142409721	142409721	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccggcaggaaatccctttcCcacccctcgggaacggaacc	9	5	10	17	3	0	0	0	0	0	0	3	3	2	3	6	4	2	1	6	4	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:142409721C>T	uc003qiu.2	-	1	216	c.75G>A	c.(73-75)TGG>TGA	p.W25*		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	25	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		AATCCCTTTCCCACCCCTCGG	0.612													10	29					0	0	0	0	T	142409721	T	T	142409721	4	4	276	1	0	0	0	0	0	1	0	0	10541	624	22	4	1109	4	NMBR	6	142409721	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4207550	142409721	28705346	672	50561											
PLAGL1	5325	broad.mit.edu	37	chr6	144262941	144262941	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttgaggtgactgaggctCttgcagaggcaagtcctcaa	9	11	12	9	0	2	4	1	3	1	1	3	4	3	4	1	3	1	3	1	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:144262941C>T	uc003qjv.2	-	3	2278	c.1012G>A	c.(1012-1014)GAG>AAG	p.E338K	PLAGL1_uc003qjx.2_Missense_Mutation_p.E338K|PLAGL1_uc003qjy.2_Missense_Mutation_p.E338K|PLAGL1_uc010khl.2_Missense_Mutation_p.E338K|PLAGL1_uc010khm.2_Missense_Mutation_p.E338K|PLAGL1_uc003qjz.2_Missense_Mutation_p.E338K|PLAGL1_uc003qka.2_Missense_Mutation_p.E338K|PLAGL1_uc003qkb.2_Missense_Mutation_p.E286K|PLAGL1_uc003qkc.2_Missense_Mutation_p.E338K|PLAGL1_uc003qkd.2_Missense_Mutation_p.E286K|PLAGL1_uc003qke.2_Missense_Mutation_p.E338K|PLAGL1_uc003qkf.2_Missense_Mutation_p.E338K|PLAGL1_uc003qkg.2_Missense_Mutation_p.E286K|PLAGL1_uc003qkh.2_Missense_Mutation_p.E338K|PLAGL1_uc003qki.2_Missense_Mutation_p.E286K|PLAGL1_uc003qkj.2_Missense_Mutation_p.E338K|PLAGL1_uc003qkk.2_Missense_Mutation_p.E286K|PLAGL1_uc003qkl.2_Missense_Mutation_p.E286K|PLAGL1_uc003qkm.2_Missense_Mutation_p.E338K|PLAGL1_uc010khn.2_Missense_Mutation_p.E338K|PLAGL1_uc003qkn.2_Missense_Mutation_p.E286K|PLAGL1_uc003qko.2_Missense_Mutation_p.E338K|PLAGL1_uc003qkp.2_Missense_Mutation_p.E286K|PLAGL1_uc003qjw.2_Missense_Mutation_p.E286K	NM_002656	NP_002647	Q9UM63	PLAL1_HUMAN	pleiomorphic adenoma gene-like 1 isoform 1	338					cell cycle arrest|induction of apoptosis|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.74e-07)|GBM - Glioblastoma multiforme(68;0.0885)		GACTGAGGCTCTTGCAGAGGC	0.483											OREG0017707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	62					0	0	0	0	T	144262941	T	T	144262941	3	4	276	1	0	0	0	0	1	0	0	0	12074	922	32	2	383	2	PLAGL1	6	144262941	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1853220	144262941	26852126	673	50562											
GRM1	2911	broad.mit.edu	37	chr6	146755382	146755382	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgaaccagccctccccaaggGcttgccccctcctctccagc	6	6	7	22	1	1	0	0	0	1	0	4	1	3	0	8	1	4	1	8	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:146755382G>A	uc010khw.1	+	9	3505	c.3035G>A	c.(3034-3036)GGC>GAC	p.G1012D	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1012	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CTCCCCAAGGGCTTGCCCCCT	0.667													26	105					0	0	0	0	A	146755382	A	A	146755382	3	1	276	1	0	0	0	0	1	0	0	0	6835	1203	42	4	3130	4	GRM1	6	146755382	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2492441	146755382	24359685	674	50563											
STXBP5	134957	broad.mit.edu	37	chr6	147635423	147635423	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggcccatcaacggaggtaaTtggggcttgggtgctcaaag	9	9	15	8	1	2	0	2	0	0	0	2	1	2	1	1	6	2	3	1	6	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:147635423T>A	uc003qlz.2	+	13	1478	c.1317T>A	c.(1315-1317)AAT>AAA	p.N439K	STXBP5_uc010khz.1_Missense_Mutation_p.N439K|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.N110K	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	439	WD 8.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		ACGGAGGTAATTGGGGCTTGG	0.313													41	132					0	0	0	0	A	147635423	A	A	147635423	3	1	276	1	0	0	0	0	1	0	0	0	15422	1490	52	5	1367	5	STXBP5	6	147635423	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	880041	147635423	23479644	675	50564											
LRP11	84918	broad.mit.edu	37	chr6	150164231	150164231	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	taggttccctcctgtaggtgGgacagcttcagggttcctga	6	12	13	10	0	1	1	1	1	0	0	4	2	4	2	3	4	1	4	3	4	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:150164231G>A	uc003qng.2	-	3	1125	c.801C>T	c.(799-801)TCC>TCT	p.S267S	LRP11_uc003qnh.1_Silent_p.S267S	NM_032832	NP_116221	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein	267	PKD.|Extracellular (Potential).					integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		CCTGTAGGTGGGACAGCTTCA	0.592													12	28					0	0	0	0	A	150164231	A	A	150164231	2	1	276	1	0	0	0	0	0	0	0	1	9003	1219	43	4		4	LRP11	6	150164231	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2528808	150164231	20950836	676	50565											
ULBP2	80328	broad.mit.edu	37	chr6	150267511	150267512	+	Missense_Mutation	DNP	CC	TT	TT																															ctctctgatgggggcagaacCcctcaccctgcaggcaagga																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:150267511_150267512CC>TT	uc003qno.2	+	3	426_427	c.353_354CC>TT	c.(352-354)CCC>CTT	p.P118L	ULBP2_uc011eeh.1_Missense_Mutation_p.P118L|ULBP2_uc010kij.2_Missense_Mutation_p.P118L	NM_025217	NP_079493	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2 precursor	118	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		GGGGCAGAACCCCTCACCCTGC	0.51													13	74					0	0	0	0	TT	150267512	TT	TT	150267511	3	4	276	1	0	0	0	0	1	0	0	0	17041	623	22	4	363	4	ULBP2	6	150267511	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	103280	150267511	20847556	677	50566											
PLEKHG1	57480	broad.mit.edu	37	chr6	151130814	151130814	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agcaagacaaacgcctctggGttctgcacctaaagagactg	13	7	10	11	1	2	2	0	0	2	2	2	3	2	2	2	1	3	3	2	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:151130814G>A	uc003qny.1	+	11	1534	c.1222G>A	c.(1222-1224)GTT>ATT	p.V408I	PLEKHG1_uc011eel.1_Missense_Mutation_p.V448I|PLEKHG1_uc011eem.1_Missense_Mutation_p.V467I|PLEKHG1_uc003qnz.2_Missense_Mutation_p.V408I	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	408	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		ACGCCTCTGGGTTCTGCACCT	0.458													9	40					0	0	0	0	A	151130814	A	A	151130814	3	1	276	1	0	0	0	0	1	0	0	0	12123	1261	44	4	1256	4	PLEKHG1	6	151130814	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	863303	151130814	19984253	678	50567											
PLEKHG1	57480	broad.mit.edu	37	chr6	151151947	151151947	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatgttcgtgccgtcattttCctcctcagatctgaactcta	7	15	7	12	2	4	2	2	1	2	1	7	3	6	2	3	0	2	1	3	0	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:151151947C>T	uc003qny.1	+	16	2012	c.1700C>T	c.(1699-1701)TCC>TTC	p.S567F	PLEKHG1_uc011eel.1_Missense_Mutation_p.S607F|PLEKHG1_uc011eem.1_Missense_Mutation_p.S626F|PLEKHG1_uc003qnz.2_Missense_Mutation_p.S567F	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	567					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		CCGTCATTTTCCTCCTCAGAT	0.517													32	68					0	0	0	0	T	151151947	T	T	151151947	3	4	276	1	0	0	0	0	1	0	0	0	12123	855	30	2	1754	2	PLEKHG1	6	151151947	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	21133	151151947	19963120	679	50568											
C6orf211	79624	broad.mit.edu	37	chr6	151779649	151779649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aatcaagatggttctactcaCcgtggttgttggtagaatgt	10	14	11	6	1	3	2	2	0	1	2	3	2	3	2	1	3	1	4	1	3	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:151779649C>T	uc003qok.1	+	3	593	c.334C>T	c.(334-336)CCG>TCG	p.P112S	C6orf211_uc011ees.1_5'UTR	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	112							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		GTTCTACTCACCGTGGTTGTT	0.328													27	31					0	0	0	0	T	151779649	T	T	151779649	3	4	276	1	0	0	0	0	1	0	0	0	2364	507	18	4	344	4	C6orf211	6	151779649	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	627702	151779649	19335418	680	50569											
TIAM2	26230	broad.mit.edu	37	chr6	155486520	155486520	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cactggccagaaaaggcaagGagaagagaccttctataact	16	6	10	9	0	1	3	0	0	1	3	1	5	1	3	2	3	1	1	2	3	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:155486520G>A	uc003qqb.2	+	11	3611	c.2338G>A	c.(2338-2340)GAG>AAG	p.E780K	TIAM2_uc003qqe.2_Missense_Mutation_p.E780K|TIAM2_uc010kjj.2_Missense_Mutation_p.E313K|TIAM2_uc003qqf.2_Missense_Mutation_p.E132K|TIAM2_uc011efl.1_Missense_Mutation_p.E92K|TIAM2_uc003qqg.2_Missense_Mutation_p.E92K	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	780					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AAAAGGCAAGGAGAAGAGACC	0.463													20	78					0	0	0	0	A	155486520	A	A	155486520	3	1	276	1	0	0	0	0	1	0	0	0	15957	1175	41	2	2360	2	TIAM2	6	155486520	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3706871	155486520	15628547	681	50570											
TFB1M	51106	broad.mit.edu	37	chr6	155618126	155618126	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagtcaaagtcatctgagtTctgccataaacaaaaggtcc	16	9	7	9	0	4	1	2	1	2	0	5	1	5	1	2	1	2	1	2	1	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:155618126T>C	uc003qqj.3	-	4	571	c.507A>G	c.(505-507)AGA>AGG	p.R169R	TFB1M_uc003qqk.2_Intron	NM_016020	NP_057104	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			skin(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		TCATCTGAGTTCTGCCATAAA	0.323													16	29					0	0	0	0	C	155618126	C	C	155618126	2	2	276	1	0	0	0	0	0	0	0	1	15859	1780	62	5		5	TFB1M	6	155618126	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	131606	155618126	15496941	682	50571											
ARID1B	57492	broad.mit.edu	37	chr6	157405953	157405953	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctcatctctccagcatccCggggggcccatctccctctc	4	9	7	21	1	4	0	1	0	3	0	9	0	6	0	5	3	1	1	5	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:157405953C>T	uc003qqn.2	+	5	2134	c.1982C>T	c.(1981-1983)CCG>CTG	p.P661L	ARID1B_uc003qqo.2_Missense_Mutation_p.P674L|ARID1B_uc003qqp.2_Missense_Mutation_p.P661L|ARID1B_uc003qqq.1_Missense_Mutation_p.P103L	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	719	Ser-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TCCAGCATCCCGGGGGGCCCA	0.597													9	77					0	0	0	0	T	157405953	T	T	157405953	3	4	276	1	0	0	0	0	1	0	0	0	914	652	23	1	2217	1	ARID1B	6	157405953	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1787827	157405953	13709114	683	50572											
SERAC1	84947	broad.mit.edu	37	chr6	158538839	158538839	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attcggagagcaggacagtcTtttgctaaccatgtctaagt	11	12	10	8	1	2	1	0	0	2	1	3	3	2	2	1	2	3	2	1	2	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:158538839T>C	uc003qrc.2	-	13	1465	c.1323A>G	c.(1321-1323)AAA>AAG	p.K441K	SERAC1_uc003qrb.2_Silent_p.K169K	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	441					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		CAGGACAGTCTTTTGCTAACC	0.403													20	80					0	0	0	0	C	158538839	C	C	158538839	2	2	276	1	0	0	0	0	0	0	0	1	14139	1606	56	5		5	SERAC1	6	158538839	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1132886	158538839	12576228	684	50573											
TULP4	56995	broad.mit.edu	37	chr6	158922890	158922890	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caaccagacgacagctgtagGgacagcagaacatgcaggtg	14	4	13	10	1	0	2	0	0	0	2	0	4	0	3	1	2	5	4	1	2	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:158922890G>C	uc003qrf.2	+	13	3552	c.2195G>C	c.(2194-2196)GGG>GCG	p.G732A	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	732					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		ACAGCTGTAGGGACAGCAGAA	0.572													22	106					0	0	0	0	C	158922890	C	C	158922890	3	2	276	1	0	0	0	0	1	0	0	0	16844	1232	43	4	2245	4	TULP4	6	158922890	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	384051	158922890	12192177	685	50574											
SYTL3	94120	broad.mit.edu	37	chr6	159184341	159184341	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgttccctcttcagctgtcTcactctgccagaccaacaaa	9	11	6	15	0	4	1	2	0	3	1	6	1	5	1	3	0	3	2	3	0	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:159184341T>A	uc003qrp.2	+	16	1767	c.1523T>A	c.(1522-1524)CTC>CAC	p.L508H	SYTL3_uc011efp.1_Missense_Mutation_p.L508H|SYTL3_uc003qro.2_Missense_Mutation_p.L440H|SYTL3_uc003qrq.2_Missense_Mutation_p.L440H|SYTL3_uc003qrr.2_Missense_Mutation_p.L508H|SYTL3_uc003qrs.2_Missense_Mutation_p.L440H|SYTL3_uc011efq.1_Missense_Mutation_p.L234H	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	508	C2 2.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TTCAGCTGTCTCACTCTGCCA	0.532													6	34					0	0	0	0	A	159184341	A	A	159184341	3	1	276	1	0	0	0	0	1	0	0	0	15550	1551	54	5	1365	5	SYTL3	6	159184341	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	261451	159184341	11930726	686	50575											
SLC22A2	6582	broad.mit.edu	37	chr6	160679479	160679479	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggctggccagggggtccAcgcagtcgaaggtgctctgg	6	6	17	12	2	1	0	0	0	1	0	3	1	2	0	3	6	1	3	3	6	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:160679479A>C	uc003qtf.2	-	1	481	c.311T>G	c.(310-312)GTG>GGG	p.V104G	SLC22A2_uc003qte.1_Missense_Mutation_p.V104G|SLC22A2_uc003qth.1_Missense_Mutation_p.V104G	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	104	Extracellular (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CAGGGGGTCCACGCAGTCGAA	0.682													16	65					0	0	0	0	C	160679479	C	C	160679479	3	2	276	1	0	0	0	0	1	0	0	0	14515	159	6	5	1400	5	SLC22A2	6	160679479	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1495138	160679479	10435588	687	50576											
LPA	4018	broad.mit.edu	37	chr6	161071470	161071470	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtggtggagtacgtgcctcGataactctgtccatcaccat	9	11	10	11	2	2	0	1	0	1	0	4	2	3	1	3	2	3	1	3	2	2	2	rs121912503		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:161071470G>A	uc003qtl.2	-	3	229	c.109C>T	c.(109-111)CGA>TGA	p.R37*		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	2545	Kringle 23.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TACGTGCCTCGATAACTCTGT	0.453													52	225					0	0	0	0	A	161071470	A	A	161071470	4	1	276	1	0	0	0	0	0	1	0	0	8953	1066	37	1	6165	1	LPA	6	161071470	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	391991	161071470	10043597	688	50577											
RPS6KA2	6196	broad.mit.edu	37	chr6	166921708	166921708	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctctttggagagccgggTgaagaggtcccctccccgca	7	7	12	15	2	1	3	0	1	1	2	3	4	3	3	6	3	1	1	6	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:166921708T>G	uc003qvb.1	-	5	661	c.442A>C	c.(442-444)ACC>CCC	p.T148P	RPS6KA2_uc011ego.1_Missense_Mutation_p.T59P|RPS6KA2_uc010kkl.1_Missense_Mutation_p.T59P|RPS6KA2_uc003qvc.1_Missense_Mutation_p.T156P|RPS6KA2_uc003qvd.1_Missense_Mutation_p.T173P	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	148	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GAGAGCCGGGTGAAGAGGTCC	0.612													6	26					0	0	0	0	G	166921708	G	G	166921708	3	3	276	1	0	0	0	0	1	0	0	0	13716	1696	59	5	1827	5	RPS6KA2	6	166921708	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	5850238	166921708	4193359	689	50578											
SMOC2	64094	broad.mit.edu	37	chr6	169053673	169053673	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agccataccctagaggagcgGgtggtgcactggtacttcaa	10	8	13	10	1	1	1	1	0	0	1	1	2	1	2	2	4	5	2	2	4	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:169053673G>A	uc003qws.1	+	11	1070	c.1050G>A	c.(1048-1050)CGG>CGA	p.R350R	SMOC2_uc003qwr.1_Silent_p.R361R|SMOC2_uc011egu.1_Silent_p.R27R	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	350	EF-hand 1.				signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		TAGAGGAGCGGGTGGTGCACT	0.517													17	32					0	0	0	0	A	169053673	A	A	169053673	2	1	276	1	0	0	0	0	0	0	0	1	14866	1219	43	4		4	SMOC2	6	169053673	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2131965	169053673	2061394	690	50579											
WDR27	253769	broad.mit.edu	37	chr6	170088966	170088966	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aagttcagttccatccaaagGgaaagcacagtcctgcatgc	13	8	9	11	0	1	0	1	0	0	0	4	1	4	1	3	1	3	4	3	1	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:170088966G>A	uc003qwx.2	-	2	656	c.136C>T	c.(136-138)CCT>TCT	p.P46S	WDR27_uc010kkw.1_Missense_Mutation_p.P46S|WDR27_uc003qwy.2_Missense_Mutation_p.P46S|WDR27_uc011egw.1_RNA|WDR27_uc010kkx.2_Missense_Mutation_p.P46S			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	46	WD 1.									pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		CCATCCAAAGGGAAAGCACAG	0.433													21	106					0	0	0	0	A	170088966	A	A	170088966	3	1	276	1	0	0	0	0	1	0	0	0	17352	1232	43	4	2533	4	WDR27	6	170088966	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1035293	170088966	1026101	691	50580											
DLL1	28514	broad.mit.edu	37	chr6	170595353	170595353	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccctggtttgtcacaaaatCcatgctgctcatcacatcca	10	11	5	15	0	3	0	3	0	0	0	5	0	5	0	4	1	2	3	4	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr6:170595353C>T	uc003qxm.2	-	5	1174	c.704G>A	c.(703-705)GGA>GAA	p.G235E		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	235	Extracellular (Potential).|EGF-like 1.				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		GTCACAAAATCCATGCTGCTC	0.483													20	72					0	0	0	0	T	170595353	T	T	170595353	3	4	276	1	0	0	0	0	1	0	0	0	4588	855	30	2	1495	2	DLL1	6	170595353	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	506387	170595353	519714	692	50581											
UNCX	340260	broad.mit.edu	37	chr7	1275522	1275523	+	Missense_Mutation	DNP	GG	AA	AA																															agaaggagaacacgaaaaagGgcccggggcggccggcgcac																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:1275522_1275523GG>AA	uc011jvw.1	+	3	505_506	c.505_506GG>AA	c.(505-507)GGC>AAC	p.G169N		NM_001080461	NP_001073930	A6NJT0	UNC4_HUMAN	UNC homeobox	169					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		CACGAAAAAGGGCCCGGGGCGG	0.653													13	40					0	0	0	0	AA	1275523	AA	AA	1275522	3	1	276	1	0	0	0	0	1	0	0	0	17066	1232	43	4	515	4	UNCX	7	1275522	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08		1275522	157863141	693	50582											
LFNG	3955	broad.mit.edu	37	chr7	2559921	2559921	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctggatctcgcgccacaaGgagatggtgagccccccgcg	8	5	13	15	4	1	2	0	1	1	1	2	4	1	3	5	3	1	0	5	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:2559921G>A	uc003smf.2	+	1	443	c.426G>A	c.(424-426)AAG>AAA	p.K142K	LFNG_uc003smg.2_Silent_p.K142K	NM_001040167	NP_001035257	Q8NES3	LFNG_HUMAN	lunatic fringe isoform a	142	Lumenal (Potential).				organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		CGCGCCACAAGGAGATGGTGA	0.622													12	43					0	0	0	0	A	2559921	A	A	2559921	2	1	276	1	0	0	0	0	0	0	0	1	8777	991	35	4		4	LFNG	7	2559921	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1284399	2559921	156578742	694	50583											
IQCE	23288	broad.mit.edu	37	chr7	2645612	2645612	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccgctctgcgggcacacCtggcccgggccaggcacagg	6	4	15	16	3	1	0	0	0	1	0	2	0	2	0	4	5	1	3	4	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:2645612C>T	uc003smo.3	+	20	2030	c.1846C>T	c.(1846-1848)CTG>TTG	p.L616L	IQCE_uc003sml.1_Silent_p.L616L|IQCE_uc011jvy.1_Silent_p.L600L|IQCE_uc011jvz.1_Silent_p.L551L|IQCE_uc003smk.3_Silent_p.L600L|IQCE_uc003smn.3_Silent_p.L551L	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	616	IQ 2.										0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		GCGGGCACACCTGGCCCGGGC	0.706													4	47					0	0	0	0	T	2645612	T	T	2645612	2	4	276	1	0	0	0	0	0	0	0	1	7845	680	24	4		4	IQCE	7	2645612	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	85691	2645612	156493051	695	50584											
SDK1	221935	broad.mit.edu	37	chr7	4153028	4153028	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggctccaaccagcgtcaCggtccgtactgccagtgaga	8	7	12	14	4	1	1	1	1	0	1	3	2	3	1	4	2	4	2	4	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:4153028C>T	uc003smx.2	+	24	3681	c.3542C>T	c.(3541-3543)ACG>ATG	p.T1181M	SDK1_uc010kso.2_Missense_Mutation_p.T457M	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1181	Fibronectin type-III 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACCAGCGTCACGGTCCGTACT	0.647													26	193					0	0	0	0	T	4153028	T	T	4153028	3	4	276	1	0	0	0	0	1	0	0	0	14033	536	19	1	3636	1	SDK1	7	4153028	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1507416	4153028	154985635	696	50585											
SDK1	221935	broad.mit.edu	37	chr7	4272892	4272892	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccatccctcttgcagatgaaGgcttatgggacatgtttgtg	8	13	11	9	0	1	2	0	1	1	1	2	3	2	3	2	2	1	3	2	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:4272892G>A	uc003smx.2	+	41	5972	c.5833G>A	c.(5833-5835)GGC>AGC	p.G1945S	SDK1_uc010kso.2_Missense_Mutation_p.G1201S|SDK1_uc003smy.2_Missense_Mutation_p.G432S|SDK1_uc003smz.2_Missense_Mutation_p.G5S	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1945	Fibronectin type-III 13.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGCAGATGAAGGCTTATGGGA	0.592													41	59					0	0	0	0	A	4272892	A	A	4272892	3	1	276	1	0	0	0	0	1	0	0	0	14033	1000	35	4	5995	4	SDK1	7	4272892	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	119864	4272892	154865771	697	50586											
RADIL	55698	broad.mit.edu	37	chr7	4874565	4874566	+	Missense_Mutation	DNP	GG	AA	AA																															gccaaggcccgggcgggcagGggctgggcctgcgcggggtc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:4874565_4874566GG>AA	uc003snj.1	-	4	1261_1262	c.1088_1089CC>TT	c.(1087-1089)CCC>CTT	p.P363L	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_5'Flank|RADIL_uc011jwc.1_Missense_Mutation_p.P123L|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	363	FHA.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GGGCGGGCAGGGGCTGGGCCTG	0.752													4	17					0	0	0	0	AA	4874566	AA	AA	4874565	3	1	276	1	0	0	0	0	1	0	0	0	13062	1219	43	4	2186	4	RADIL	7	4874565	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	601673	4874565	154264098	698	50587											
PAPOLB	56903	broad.mit.edu	37	chr7	4901389	4901389	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggagacgccgtagcgattcGgcggcggcgccggctgcggt	5	5	19	12	9	0	1	0	0	0	1	1	3	0	1	2	6	2	2	2	6	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:4901389G>A	uc003snk.2	-	1	237	c.53C>T	c.(52-54)CCG>CTG	p.P18L	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	17					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		GTAGCGATTCGGCGGCGGCGC	0.672													9	13					0	0	0	0	A	4901389	A	A	4901389	3	1	276	1	0	0	0	0	1	0	0	0	11484	1116	39	1	1864	1	PAPOLB	7	4901389	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	26824	4901389	154237274	699	50588											
TNRC18	84629	broad.mit.edu	37	chr7	5410575	5410575	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacaaagtctggacactcaGagggctctgcgcagctctgc	9	7	11	14	1	4	1	1	0	3	1	4	2	4	2	1	2	3	3	1	2	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:5410575G>A	uc003soi.3	-	11	3999	c.3650C>T	c.(3649-3651)TCT>TTT	p.S1217F		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1217							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		TGGACACTCAGAGGGCTCTGC	0.692													11	82					0	0	0	0	A	5410575	A	A	5410575	3	1	276	1	0	0	0	0	1	0	0	0	16405	942	33	2	5336	2	TNRC18	7	5410575	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	509186	5410575	153728088	700	50589											
AIMP2	7965	broad.mit.edu	37	chr7	6063300	6063300	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaacctggctccttttaacaCggccctcaagctccttaagt	10	11	6	14	1	1	0	1	0	0	0	3	0	3	0	4	2	3	2	4	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:6063300C>T	uc003spo.2	+	4	1054	c.941C>T	c.(940-942)ACG>ATG	p.T314M	EIF2AK1_uc003spp.2_3'UTR|EIF2AK1_uc003spq.2_3'UTR|EIF2AK1_uc011jwm.1_3'UTR	NM_006303	NP_006294	Q13155	AIMP2_HUMAN	aminoacyl tRNA synthetase complex-interacting	314	GST C-terminal.				apoptosis|cell differentiation|multicellular organismal development|tRNA aminoacylation for protein translation	cytosol|nucleus	protein binding			ovary(1)	1						CCTTTTAACACGGCCCTCAAG	0.468													14	76					0	0	0	0	T	6063300	T	T	6063300	3	4	276	1	0	0	0	0	1	0	0	0	434	536	19	1	955	1	AIMP2	7	6063300	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	652725	6063300	153075363	701	50590											
COL28A1	340267	broad.mit.edu	37	chr7	7516750	7516750	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggtattgttacctttggtCctggaaatccttctccgggt	7	15	10	9	1	1	0	0	0	1	0	4	1	3	1	4	4	1	2	4	4	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:7516750C>T	uc003src.1	-	14	1343	c.1226G>A	c.(1225-1227)GGA>GAA	p.G409E	COL28A1_uc011jxe.1_Missense_Mutation_p.G92E|COL28A1_uc003srd.2_5'UTR	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	409					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity	p.G409R(1)		skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TACCTTTGGTCCTGGAAATCC	0.383													44	73					0	0	0	0	T	7516750	T	T	7516750	3	4	276	1	0	0	0	0	1	0	0	0	3701	855	30	2	2239	2	COL28A1	7	7516750	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1453450	7516750	151621913	702	50591											
ICA1	3382	broad.mit.edu	37	chr7	8167554	8167554	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttggtctaaaagctgcgaagGaaggaaacctgagcctgtct	12	9	12	8	1	2	1	0	1	2	0	2	4	2	3	2	3	4	1	2	3	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:8167554G>A	uc003srm.2	-	13	1346	c.1279C>T	c.(1279-1281)CCT>TCT	p.P427S	ICA1_uc010ktr.2_Missense_Mutation_p.P456S|ICA1_uc003srl.2_Missense_Mutation_p.P415S|ICA1_uc003srn.3_Missense_Mutation_p.P353S|ICA1_uc003srp.3_Missense_Mutation_p.P426S|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Missense_Mutation_p.P427S|ICA1_uc003srr.2_Missense_Mutation_p.P426S|ICA1_uc003sro.3_Missense_Mutation_p.P427S	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	427					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		AGCTGCGAAGGAAGGAAACCT	0.517													39	214					0	0	0	0	A	8167554	A	A	8167554	3	1	276	1	0	0	0	0	1	0	0	0	7516	1174	41	2	180	2	ICA1	7	8167554	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	650804	8167554	150971109	703	50592											
THSD7A	221981	broad.mit.edu	37	chr7	11446682	11446683	+	Splice_Site	DNP	CC	TT	TT																															ttcgtcttcggatcatttttCcttgaagagatacaaagtga																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:11446682_11446683CC>TT	uc003ssf.3	-	20	4169	c.3917_splice	c.e20-1	p.G1306_splice		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A							integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GATCATTTTTCCTTGAAGAGAT	0.455										HNSCC(18;0.044)			5	46					0	0	0	0	TT	11446683	TT	TT	11446682	5	4	276	1	0	0	0	0	0	0	1	0	15945	869	30	2	1088	2	THSD7A	7	11446682	Splice_Site	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	3279128	11446682	147691981	704	50593											
THSD7A	221981	broad.mit.edu	37	chr7	11582619	11582619	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctgatcattacagttttCataagtacaaggtccccaag	12	13	7	9	0	2	1	2	1	0	0	3	1	3	1	2	1	3	3	2	1	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:11582619C>T	uc003ssf.3	-	5	1831	c.1579G>A	c.(1579-1581)GAA>AAA	p.E527K		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	527	TSP type-1 5.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTACAGTTTTCATAAGTACAA	0.393										HNSCC(18;0.044)			23	48					0	0	0	0	T	11582619	T	T	11582619	3	4	276	1	0	0	0	0	1	0	0	0	15945	835	29	2	3486	2	THSD7A	7	11582619	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	135937	11582619	147556044	705	50594											
HDAC9	9734	broad.mit.edu	37	chr7	18688107	18688107	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtggagttcccttacatcCtcagtctcccttggcaacaa	9	11	8	13	0	2	0	1	0	1	0	5	1	4	1	3	3	2	2	3	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:18688107C>T	uc003suh.2	+	10	1300	c.1259C>T	c.(1258-1260)CCT>CTT	p.P420L	HDAC9_uc003sue.2_Missense_Mutation_p.P420L|HDAC9_uc011jyd.1_Missense_Mutation_p.P420L|HDAC9_uc003sui.2_Missense_Mutation_p.P423L|HDAC9_uc003suj.2_Missense_Mutation_p.P379L|HDAC9_uc011jya.1_Missense_Mutation_p.P417L|HDAC9_uc003sua.1_Missense_Mutation_p.P398L|HDAC9_uc011jyb.1_Missense_Mutation_p.P376L|HDAC9_uc003sud.1_Missense_Mutation_p.P420L|HDAC9_uc011jyc.1_Missense_Mutation_p.P379L|HDAC9_uc003suf.1_Missense_Mutation_p.P451L|HDAC9_uc010kud.1_Missense_Mutation_p.P423L|HDAC9_uc011jye.1_Missense_Mutation_p.P392L|HDAC9_uc011jyf.1_Missense_Mutation_p.P343L|HDAC9_uc010kue.1_Missense_Mutation_p.P163L	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	420					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CCCTTACATCCTCAGTCTCCC	0.353													10	78					0	0	0	0	T	18688107	T	T	18688107	3	4	276	1	0	0	0	0	1	0	0	0	7053	681	24	4	1306	4	HDAC9	7	18688107	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	7105488	18688107	140450556	706	50595											
ABCB5	340273	broad.mit.edu	37	chr7	20685402	20685402	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcatctcattgaccagtaaGgaattaagtgcctattccaa	13	12	7	9	0	2	1	2	1	1	0	4	2	3	2	3	1	1	1	3	1	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:20685402G>A	uc003suw.3	+						ABCB5_uc010kuh.2_Silent_p.K234K|ABCB5_uc003suv.3_5'Flank|ABCB5_uc011jyi.1_5'Flank	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5						regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TGACCAGTAAGGAATTAAGTG	0.403													30	136					0	0	0	0	A	20685402	A	A	20685402	1	1	276	0	1	0	0	0	0	0	0	0	44	991	35	4		4	ABCB5	7	20685402	5'Flank	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1997295	20685402	138453261	707	50596											
DNAH11	8701	broad.mit.edu	37	chr7	21627720	21627720	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattttctagagaagccagtTgtcatggaaattttcagcct	12	14	8	7	0	3	1	2	0	1	1	3	3	3	2	2	1	2	1	2	1	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:21627720T>G	uc003svc.2	+	10	1780	c.1749T>G	c.(1747-1749)GTT>GTG	p.V583V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	583	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGAAGCCAGTTGTCATGGAAA	0.348									Kartagener_syndrome				10	63					0	0	0	0	G	21627720	G	G	21627720	2	3	276	1	0	0	0	0	0	0	0	1	4621	1799	63	5		5	DNAH11	7	21627720	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	942318	21627720	137510943	708	50597											
DNAH11	8701	broad.mit.edu	37	chr7	21639524	21639524	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataatgcacgacttagacttCtttctgaagaatacagagaa	16	11	7	7	1	2	4	0	1	2	3	2	6	2	4	0	0	2	1	0	0	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:21639524C>T	uc003svc.2	+	15	2818	c.2787C>T	c.(2785-2787)TTC>TTT	p.F929F		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	929	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ACTTAGACTTCTTTCTGAAGA	0.398									Kartagener_syndrome				8	38					0	0	0	0	T	21639524	T	T	21639524	2	4	276	1	0	0	0	0	0	0	0	1	4621	912	32	2		2	DNAH11	7	21639524	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	11804	21639524	137499139	709	50598											
DNAH11	8701	broad.mit.edu	37	chr7	21744165	21744165	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccctggatgtgccccggagGaggaagctgcactttgaaca	9	7	14	11	1	0	1	0	1	0	0	0	5	0	5	3	4	4	2	3	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:21744165G>A	uc003svc.2	+	39	6439	c.6408G>A	c.(6406-6408)AGG>AGA	p.R2136R		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2136					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TGCCCCGGAGGAGGAAGCTGC	0.522									Kartagener_syndrome				7	52					0	0	0	0	A	21744165	A	A	21744165	2	1	276	1	0	0	0	0	0	0	0	1	4621	1165	41	2		2	DNAH11	7	21744165	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	104641	21744165	137394498	710	50599											
IGF2BP3	10643	broad.mit.edu	37	chr7	23391088	23391088	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaggagcccctctgcccaagCccccggcgacctcggggctg	5	4	14	18	3	1	0	0	0	1	0	2	3	1	1	6	4	3	1	6	4	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:23391088C>T	uc003swg.2	-	6	785	c.519G>A	c.(517-519)GGG>GGA	p.G173G		NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	173					anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						TCTGCCCAAGCCCCCGGCGAC	0.557													14	49					0	0	0	0	T	23391088	T	T	23391088	2	4	276	1	0	0	0	0	0	0	0	1	7614	726	26	4		4	IGF2BP3	7	23391088	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1646923	23391088	135747575	711	50600											
NPVF	64111	broad.mit.edu	37	chr7	25268016	25268016	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttaacaagcttgaagtggCtaaagtcaataaaatgaata	18	11	8	4	0	1	2	1	2	0	0	1	2	1	2	0	1	2	3	0	1	10	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:25268016C>A	uc003sxo.2	-	1	90	c.43G>T	c.(43-45)GCC>TCC	p.A15S		NM_022150	NP_071433	Q9HCQ7	RFRP_HUMAN	neuropeptide VF precursor	15					neuropeptide signaling pathway	extracellular region|membrane	G-protein coupled receptor activity			ovary(1)	1						CTTGAAGTGGCTAAAGTCAAT	0.303													13	56					2.27111e-07	2.31214e-07	1	0	A	25268016	A	A	25268016	3	1	276	1	0	0	0	0	1	0	0	0	10659	797	28	4	559	4	NPVF	7	25268016	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1876928	25268016	133870647	712	50601											
HOXA3	3200	broad.mit.edu	37	chr7	27148004	27148004	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggcgactggggctcatacgGgacgctgttgaccagcgaat	8	7	16	10	4	1	1	1	1	0	0	1	4	1	2	1	4	2	3	1	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:27148004G>A	uc011jzl.1	-	3	1062	c.862C>T	c.(862-864)CCG>TCG	p.P288S	HOXA3_uc011jzk.1_Missense_Mutation_p.P130S|HOXA3_uc003syk.2_Missense_Mutation_p.P288S	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	288					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						GGCTCATACGGGACGCTGTTG	0.687													14	66					0	0	0	0	A	27148004	A	A	27148004	3	1	276	1	0	0	0	0	1	0	0	0	7332	1232	43	4	473	4	HOXA3	7	27148004	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1879988	27148004	131990659	713	50602											
CHN2	1124	broad.mit.edu	37	chr7	29544359	29544359	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctctctctctctctaacaGgattaaaatcggaaggcctt	10	13	6	12	1	4	0	0	0	4	0	8	2	4	2	1	3	1	0	1	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:29544359G>A	uc003szz.2	+	10	1351	c.914_splice	c.e10-1	p.G305_splice	CHN2_uc011jzs.1_Splice_Site_p.G380_splice|CHN2_uc010kva.2_Splice_Site_p.G75_splice|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Splice_Site_p.G270_splice|CHN2_uc011jzt.1_Splice_Site_p.G318_splice|CHN2_uc010kvd.2_Splice_Site_p.G161_splice|CHN2_uc011jzu.1_Splice_Site_p.G290_splice|CHN2_uc010kvg.2_Splice_Site_p.G169_splice|CHN2_uc010kvh.2_Splice_Site_p.G111_splice|CHN2_uc010kvi.2_Intron|CHN2_uc010kve.2_Splice_Site_p.G169_splice|CHN2_uc003taa.2_Splice_Site_p.G169_splice|CHN2_uc010kvf.2_Splice_Site_p.G111_splice|CHN2_uc010kvj.2_Splice_Site_p.G124_splice|CHN2_uc010kvk.2_Splice_Site|CHN2_uc010kvl.2_Splice_Site|CHN2_uc010kvm.2_Splice_Site_p.G124_splice|CHN2_uc011jzv.1_Splice_Site_p.G98_splice	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						CTCTCTAACAGGATTAAAATC	0.353													10	53					0	0	0	0	A	29544359	A	A	29544359	5	1	276	1	0	0	0	0	0	0	1	0	3378	1014	35	4	1119	4	CHN2	7	29544359	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2396355	29544359	129594304	714	50603											
FKBP14	55033	broad.mit.edu	37	chr7	30066080	30066080	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcaaagccccaatcaaagaAgtgacgaacagagtcaagac	19	4	8	10	1	3	4	3	1	0	3	3	5	3	4	2	0	2	0	2	0	6	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:30066080A>T	uc003tal.1	-	1	189	c.45T>A	c.(43-45)ACT>ACA	p.T15T	PLEKHA8_uc003tao.2_5'Flank|PLEKHA8_uc003tap.1_5'Flank|FKBP14_uc010kvq.1_RNA|PLEKHA8_uc003tam.1_5'Flank|PLEKHA8_uc003tan.2_5'Flank	NM_017946	NP_060416	Q9NWM8	FKB14_HUMAN	FK506 binding protein 14 precursor	15					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						CAATCAAAGAAGTGACGAACA	0.473													32	62					0	0	0	0	T	30066080	T	T	30066080	2	4	276	1	0	0	0	0	0	0	0	1	5936	59	3	5		5	FKBP14	7	30066080	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	521721	30066080	129072583	715	50604											
NOD1	10392	broad.mit.edu	37	chr7	30491316	30491316	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaagaggtcttcccgcgccgGaccactgccctgcaggcact	7	6	12	16	3	1	1	0	0	1	1	2	3	2	2	4	3	2	2	4	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:30491316G>A	uc003tav.2	-	6	2240	c.1717C>T	c.(1717-1719)CCG>TCG	p.P573S		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	573					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						TCCCGCGCCGGACCACTGCCC	0.607													13	65					0	0	0	0	A	30491316	A	A	30491316	3	1	276	1	0	0	0	0	1	0	0	0	10570	1174	41	2	1180	2	NOD1	7	30491316	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	425236	30491316	128647347	716	50605											
FKBP9	11328	broad.mit.edu	37	chr7	33039805	33039805	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggacatgggtctcagagaGatgtgcgttggcgagaaacg	11	8	16	6	3	1	3	1	0	1	3	2	6	1	4	0	3	2	1	0	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:33039805G>A	uc003tdh.2	+	8	1486	c.1305G>A	c.(1303-1305)GAG>GAA	p.E435E	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Silent_p.E488E|FKBP9_uc011kam.1_Silent_p.E203E	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	435	PPIase FKBP-type 4.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			GTCTCAGAGAGATGTGCGTTG	0.502													19	105					0	0	0	0	A	33039805	A	A	33039805	2	1	276	1	0	0	0	0	0	0	0	1	5947	933	33	2		2	FKBP9	7	33039805	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2548489	33039805	126098858	717	50606											
BBS9	27241	broad.mit.edu	37	chr7	33376101	33376101	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgatgatggtcacttgcaGtgttcatacctggggacaga	10	11	13	7	0	2	3	2	2	0	1	2	4	2	4	1	3	2	2	1	3	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:33376101G>A	uc003tdn.1	+	10	1578	c.1065G>A	c.(1063-1065)CAG>CAA	p.Q355Q	BBS9_uc003tdo.1_Silent_p.Q355Q|BBS9_uc003tdp.1_Silent_p.Q355Q|BBS9_uc003tdq.1_Silent_p.Q355Q|BBS9_uc010kwn.1_RNA|BBS9_uc011kao.1_Silent_p.Q233Q	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	355					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding	p.Q355H(1)		ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GTCACTTGCAGTGTTCATACC	0.373									Bardet-Biedl_syndrome				12	42					0	0	0	0	A	33376101	A	A	33376101	2	1	276	1	0	0	0	0	0	0	0	1	1344	1020	36	4		4	BBS9	7	33376101	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	336296	33376101	125762562	718	50607											
AOAH	313	broad.mit.edu	37	chr7	36580098	36580098	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggactgggtcactcttcCtgttggtggaataaacagaa	10	11	12	8	0	2	1	1	0	1	1	3	3	3	3	1	4	1	1	1	4	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:36580098C>T	uc003tfh.3	-	16	1535	c.1134_splice	c.e16-1	p.G378_splice	AOAH_uc010kxf.2_Splice_Site_p.G378_splice|AOAH_uc011kba.1_Splice_Site_p.G346_splice	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor						inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						GTCACTCTTCCTGTTGGTGGA	0.408													20	97					0	0	0	0	T	36580098	T	T	36580098	5	4	276	1	0	0	0	0	0	0	1	0	726	695	24	4	959	4	AOAH	7	36580098	Splice_Site	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3203997	36580098	122558565	719	50608											
TXNDC3	51314	broad.mit.edu	37	chr7	37907425	37907425	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accacagactgacaccgaacCtaacgaacgatctgaggatc	15	5	8	13	3	1	3	0	2	1	1	2	7	1	4	3	1	3	0	3	1	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:37907425C>T	uc003tfn.2	+	11	1115	c.743C>T	c.(742-744)CCT>CTT	p.P248L		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	248	NDK 1.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						GACACCGAACCTAACGAACGA	0.438									Kartagener_syndrome				12	31					0	0	0	0	T	37907425	T	T	37907425	3	4	276	1	0	0	0	0	1	0	0	0	16866	681	24	4	777	4	TXNDC3	7	37907425	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1327327	37907425	121231238	720	50609											
TXNDC3	51314	broad.mit.edu	37	chr7	37927979	37927979	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaatacagcatttctttcctCttcaaagcactttaggcttg	11	15	5	10	0	3	0	1	0	2	0	4	0	4	0	1	1	3	3	1	1	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:37927979C>T	uc003tfn.2	+	15	1720	c.1348C>T	c.(1348-1350)CTT>TTT	p.L450F		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	450	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TTTCTTTCCTCTTCAAAGCAC	0.368									Kartagener_syndrome				8	62					0	0	0	0	T	37927979	T	T	37927979	3	4	276	1	0	0	0	0	1	0	0	0	16866	913	32	2	1398	2	TXNDC3	7	37927979	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	20554	37927979	121210684	721	50610											
SFRP4	6424	broad.mit.edu	37	chr7	37947224	37947224	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccggctgttttcttcttgtCctgaactgttctccgctgtt	2	18	8	13	2	3	1	0	1	3	0	5	1	4	1	3	1	1	5	3	1	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:37947224C>T	uc003tfo.3	-	6	1284	c.898G>A	c.(898-900)GAC>AAC	p.D300N		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	300	NTR.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						TTCTTCTTGTCCTGAACTGTT	0.493													17	76					0	0	0	0	T	37947224	T	T	37947224	3	4	276	1	0	0	0	0	1	0	0	0	14228	855	30	2	146	2	SFRP4	7	37947224	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	19245	37947224	121191439	722	50611											
CDK13	8621	broad.mit.edu	37	chr7	40027827	40027827	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accaccgttacctttgcctcCcatgctgcctgaagataaag	10	10	7	14	1	0	2	0	1	0	1	1	2	1	2	6	0	4	2	6	0	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:40027827C>T	uc003thh.3	+	2	2123	c.1841C>T	c.(1840-1842)CCC>CTC	p.P614L	CDK13_uc003thi.3_Missense_Mutation_p.P614L|CDK13_uc011kbf.1_5'UTR	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	614					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						CCTTTGCCTCCCATGCTGCCT	0.398													22	82					0	0	0	0	T	40027827	T	T	40027827	3	4	276	1	0	0	0	0	1	0	0	0	3144	623	22	4	1847	4	CDK13	7	40027827	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2080603	40027827	119110836	723	50612											
CDK13	8621	broad.mit.edu	37	chr7	40127730	40127730	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttttttttttcagtctccCtttatggcaagattgtcatg	6	21	6	8	0	3	1	2	0	1	1	4	1	3	1	1	1	0	1	1	1	2	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:40127730C>T	uc003thh.3	+	12	3317	c.3035C>T	c.(3034-3036)CCT>CTT	p.P1012L	CDK13_uc003thi.3_Missense_Mutation_p.P1012L|CDK13_uc003thj.2_Missense_Mutation_p.P63L	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	1012					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						TTCAGTCTCCCTTTATGGCAA	0.373													10	37					0	0	0	0	T	40127730	T	T	40127730	3	4	276	1	0	0	0	0	1	0	0	0	3144	681	24	4	3081	4	CDK13	7	40127730	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	99903	40127730	119010933	724	50613											
HECW1	23072	broad.mit.edu	37	chr7	43484379	43484379	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaaagcaggccctgctcCttgcctgtgtccgagctgga	9	8	12	12	1	0	1	0	0	0	1	2	3	2	2	4	2	4	3	4	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:43484379C>T	uc003tid.1	+	11	2213	c.1608C>T	c.(1606-1608)TCC>TCT	p.S536S	HECW1_uc011kbi.1_Silent_p.S536S	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	536					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GGCCCTGCTCCTTGCCTGTGT	0.582													4	29					0	0	0	0	T	43484379	T	T	43484379	2	4	276	1	0	0	0	0	0	0	0	1	7081	668	24	4		4	HECW1	7	43484379	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3356649	43484379	115654284	725	50614											
HECW1	23072	broad.mit.edu	37	chr7	43484409	43484409	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccgagctggagacggtgatCgcgtcagcctgcggggaccc	6	6	16	13	5	1	2	1	1	0	1	3	5	2	3	3	4	3	1	3	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:43484409C>T	uc003tid.1	+	11	2243	c.1638C>T	c.(1636-1638)ATC>ATT	p.I546I	HECW1_uc011kbi.1_Silent_p.I546I	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	546					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGACGGTGATCGCGTCAGCCT	0.687													5	50					0	0	0	0	T	43484409	T	T	43484409	2	4	276	1	0	0	0	0	0	0	0	1	7081	874	31	1		1	HECW1	7	43484409	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	30	43484409	115654254	726	50615											
BLVRA	644	broad.mit.edu	37	chr7	43832321	43832321	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtttaccaaaggcagttcCttaatgctggcaagcacgtc	10	11	9	11	2	0	0	0	0	0	0	3	0	1	0	2	2	3	6	2	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:43832321C>G	uc003tir.2	+	5	345	c.262C>G	c.(262-264)CTT>GTT	p.L88V	BLVRA_uc010kxv.2_Missense_Mutation_p.L88V	NM_000712	NP_000703	P53004	BIEA_HUMAN	biliverdin reductase A precursor	88					heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			ovary(1)	1					NADH(DB00157)	AAGGCAGTTCCTTAATGCTGG	0.453													12	27					0	0	0	0	G	43832321	G	G	43832321	3	3	276	1	0	0	0	0	1	0	0	0	1454	681	24	4	276	4	BLVRA	7	43832321	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	347912	43832321	115306342	727	50616											
NPC1L1	29881	broad.mit.edu	37	chr7	44579040	44579040	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaggctggtgcccttcttgGggtccaccatcttgcttttg	4	14	12	11	0	2	1	0	0	2	1	3	1	3	1	3	4	2	2	3	4	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:44579040G>A	uc003tlb.2	-	2	1012	c.956C>T	c.(955-957)CCC>CTC	p.P319L	NPC1L1_uc003tlc.2_Missense_Mutation_p.P319L|NPC1L1_uc011kbw.1_Missense_Mutation_p.P319L|NPC1L1_uc003tld.2_Missense_Mutation_p.P319L	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	319	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCCCTTCTTGGGGTCCACCAT	0.607													32	81					0	0	0	0	A	44579040	A	A	44579040	3	1	276	1	0	0	0	0	1	0	0	0	10625	1232	43	4	3199	4	NPC1L1	7	44579040	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	746719	44579040	114559623	728	50617											
OGDH	4967	broad.mit.edu	37	chr7	44741144	44741144	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tattgttctgtatttcagttAattatcttcacccccaaatc	10	18	3	10	0	4	0	2	0	2	0	5	0	4	0	2	0	0	3	2	0	5	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:44741144A>C	uc003tln.2	+	20	2671	c.2562A>C	c.(2560-2562)TTA>TTC	p.L854F	OGDH_uc011kbx.1_Missense_Mutation_p.L850F|OGDH_uc011kby.1_Missense_Mutation_p.L704F|OGDH_uc003tlp.2_Missense_Mutation_p.L865F|OGDH_uc011kbz.1_Missense_Mutation_p.L649F	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	854					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TATTTCAGTTAATTATCTTCA	0.498													21	34					0	0	0	0	C	44741144	C	C	44741144	3	2	276	1	0	0	0	0	1	0	0	0	10893	359	13	5	2809	5	OGDH	7	44741144	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	162104	44741144	114397519	729	50618											
ZMIZ2	83637	broad.mit.edu	37	chr7	44804988	44804988	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagctggaagccagtgccCgtgaagcctgacatgcacat	10	7	12	12	1	0	2	0	2	0	0	0	3	0	3	3	1	6	3	3	1	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:44804988C>T	uc003tlr.2	+	16	2175	c.2052C>T	c.(2050-2052)CCC>CCT	p.P684P	ZMIZ2_uc003tlq.2_Silent_p.P626P|ZMIZ2_uc003tls.2_Silent_p.P658P|ZMIZ2_uc003tlt.2_Silent_p.P307P|ZMIZ2_uc010kyj.2_Silent_p.P206P|ZMIZ2_uc003tlu.2_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	684					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						AGCCAGTGCCCGTGAAGCCTG	0.642													14	37					0	0	0	0	T	44804988	T	T	44804988	2	4	276	1	0	0	0	0	0	0	0	1	17764	639	23	1		1	ZMIZ2	7	44804988	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	63844	44804988	114333675	730	50619											
ZMIZ2	83637	broad.mit.edu	37	chr7	44805102	44805102	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgatggagatgatcgccgcCctgggccccggcgctgcccc	4	6	15	16	4	0	3	0	2	0	1	1	4	0	3	6	3	1	1	6	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:44805102C>T	uc003tlr.2	+	16	2289	c.2166C>T	c.(2164-2166)GCC>GCT	p.A722A	ZMIZ2_uc003tlq.2_Silent_p.A664A|ZMIZ2_uc003tls.2_Silent_p.A696A|ZMIZ2_uc003tlt.2_Silent_p.A345A|ZMIZ2_uc010kyj.2_Silent_p.A244A|ZMIZ2_uc003tlu.2_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	722					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						TGATCGCCGCCCTGGGCCCCG	0.692													10	22					0	0	0	0	T	44805102	T	T	44805102	2	4	276	1	0	0	0	0	0	0	0	1	17764	610	22	4		4	ZMIZ2	7	44805102	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	114	44805102	114333561	731	50620											
MYO1G	64005	broad.mit.edu	37	chr7	45004019	45004019	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcccttgtctaaccttgcGgacatggcttgaaaagagca	10	11	10	10	1	1	2	0	1	1	1	2	3	2	3	2	2	3	2	2	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:45004019G>A	uc003tmh.2	-	19	2770	c.2626C>T	c.(2626-2628)CGC>TGC	p.R876C	MYO1G_uc003tmf.2_Missense_Mutation_p.R319C|MYO1G_uc003tmg.2_Missense_Mutation_p.R638C|MYO1G_uc010kym.2_Missense_Mutation_p.R761C	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	876				R->A: No effect on membrane localization.		myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						CTAACCTTGCGGACATGGCTT	0.527													19	59					0	0	0	0	A	45004019	A	A	45004019	3	1	276	1	0	0	0	0	1	0	0	0	10127	1116	39	1	446	1	MYO1G	7	45004019	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	198917	45004019	114134644	732	50621											
ADCY1	107	broad.mit.edu	37	chr7	45650062	45650062	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agccccctgagaggattttcCacaagatttacatccagagg	12	9	9	11	0	0	3	0	1	0	3	2	5	2	4	4	2	2	0	4	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:45650062C>T	uc003tne.3	+	3	892	c.874C>T	c.(874-876)CAC>TAC	p.H292Y	ADCY1_uc003tnd.2_Missense_Mutation_p.H67Y	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	292	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GAGGATTTTCCACAAGATTTA	0.537													45	99					0	0	0	0	T	45650062	T	T	45650062	3	4	276	1	0	0	0	0	1	0	0	0	292	594	21	4	884	4	ADCY1	7	45650062	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	646043	45650062	113488601	733	50622											
ADCY1	107	broad.mit.edu	37	chr7	45743070	45743070	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacgtcgcccagcacttcctCatgtccaaccctcggaacat	9	8	6	18	3	1	0	1	0	0	0	5	1	3	1	4	1	3	1	4	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:45743070C>T	uc003tne.3	+	15	2568	c.2550C>T	c.(2548-2550)CTC>CTT	p.L850L		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	850	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGCACTTCCTCATGTCCAACC	0.637													5	36					0	0	0	0	T	45743070	T	T	45743070	2	4	276	1	0	0	0	0	0	0	0	1	292	813	29	2		2	ADCY1	7	45743070	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	93008	45743070	113395593	734	50623											
TNS3	64759	broad.mit.edu	37	chr7	47323382	47323382	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtggaggctcctggaccaggGtgatgctcagggccttctgg	5	9	17	10	0	2	1	1	1	1	0	3	3	3	3	3	6	1	2	3	6	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:47323382G>A	uc003tnv.2	-	28	4377	c.4010C>T	c.(4009-4011)ACC>ATC	p.T1337I	TNS3_uc003tnw.2_Missense_Mutation_p.T1337I	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	1337						focal adhesion	protein binding			ovary(4)	4						CTGGACCAGGGTGATGCTCAG	0.577													12	71					0	0	0	0	A	47323382	A	A	47323382	3	1	276	1	0	0	0	0	1	0	0	0	16410	1261	44	4	343	4	TNS3	7	47323382	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1580312	47323382	111815281	735	50624											
PKD1L1	168507	broad.mit.edu	37	chr7	47842808	47842808	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ataaaggggagagttcttacCcctgctacaaagatgctggg	12	9	12	8	0	1	2	0	0	1	2	1	3	1	2	2	3	4	3	2	3	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:47842808C>T	uc003tny.1	-	53	7962	c.7962G>A	c.(7960-7962)GGG>GGA	p.G2654G	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2654	Helical; (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GAGTTCTTACCCCTGCTACAA	0.453													8	83					0	0	0	0	T	47842808	T	T	47842808	2	4	276	1	0	0	0	0	0	0	0	1	12019	637	22	4		4	PKD1L1	7	47842808	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	519426	47842808	111295855	736	50625											
SUN3	256979	broad.mit.edu	37	chr7	48033956	48033956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actggagatgtttcctgacgGagacaccttctctgagatgt	9	12	11	9	1	1	4	0	2	1	3	3	7	2	4	2	2	0	1	2	2	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:48033956G>A	uc003tof.2	-	9	914	c.817C>T	c.(817-819)CCG>TCG	p.P273S	SUN3_uc010kyq.2_Missense_Mutation_p.P173S|SUN3_uc003tog.2_Missense_Mutation_p.P273S|SUN3_uc011kcf.1_Missense_Mutation_p.P261S	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	273	SUN.					integral to membrane				central_nervous_system(1)	1						TTTCCTGACGGAGACACCTTC	0.453													75	125					0	0	0	0	A	48033956	A	A	48033956	3	1	276	1	0	0	0	0	1	0	0	0	15459	1174	41	2	268	2	SUN3	7	48033956	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	191148	48033956	111104707	737	50626											
ABCA13	154664	broad.mit.edu	37	chr7	48528921	48528921	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtggcagcacctaccccctaCtgtggactggagacaatacg	10	7	11	13	1	0	1	0	0	0	1	0	3	0	2	3	3	4	2	3	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:48528921C>T	uc003toq.2	+	48	13296	c.13271C>T	c.(13270-13272)ACT>ATT	p.T4424I	ABCA13_uc010kys.1_Missense_Mutation_p.T1499I|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Missense_Mutation_p.T154I	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4424					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CTACCCCCTACTGTGGACTGG	0.343													7	28					0	0	0	0	T	48528921	T	T	48528921	3	4	276	1	0	0	0	0	1	0	0	0	31	565	20	4	13290	4	ABCA13	7	48528921	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	494965	48528921	110609742	738	50627											
DDC	1644	broad.mit.edu	37	chr7	50605614	50605614	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caaaaatgcctttggtagttCcagcatcttcccgagccagt	10	11	8	12	1	1	0	0	0	1	0	3	1	3	0	4	1	3	3	4	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:50605614C>T	uc003tpf.3	-	4	465	c.379G>A	c.(379-381)GAA>AAA	p.E127K	DDC_uc010kza.2_Intron|DDC_uc003tpg.3_Missense_Mutation_p.E127K	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	127	2.|2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	TTTGGTAGTTCCAGCATCTTC	0.567													24	76					0	0	0	0	T	50605614	T	T	50605614	3	4	276	1	0	0	0	0	1	0	0	0	4342	864	30	2	1107	2	DDC	7	50605614	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2076693	50605614	108533049	739	50628											
ZNF479	90827	broad.mit.edu	37	chr7	57188704	57188704	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gttaacttcactataacctcCcttgtgcacctcatattcac	10	14	3	14	0	3	0	3	0	0	0	4	0	4	0	3	0	3	2	3	0	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:57188704C>T	uc010kzo.2	-	5	689	c.418G>A	c.(418-420)GGA>AGA	p.G140R		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			CTATAACCTCCCTTGTGCACC	0.313													34	155					0	0	0	0	T	57188704	T	T	57188704	3	4	276	1	0	0	0	0	1	0	0	0	18000	632	22	4	1160	4	ZNF479	7	57188704	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6583090	57188704	101949959	740	50629											
CALN1	83698	broad.mit.edu	37	chr7	71488753	71488753	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcaaaatccacctggccatcCcctgcaaggagaagatgtaa	14	7	8	12	0	1	2	1	0	0	2	3	3	3	2	5	2	1	2	5	2	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:71488753C>T	uc003twa.3	-	4	791	c.264G>A	c.(262-264)GGG>GGA	p.G88G	CALN1_uc003twb.3_Silent_p.G130G|CALN1_uc003twc.3_Silent_p.G88G	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	88	2 (Potential).|EF-hand 2.|Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CCTGGCCATCCCCTGCAAGGA	0.458													13	106					0	0	0	0	T	71488753	T	T	71488753	2	4	276	1	0	0	0	0	0	0	0	1	2603	637	22	4		4	CALN1	7	71488753	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	14300049	71488753	87649910	741	50630											
TBL2	26608	broad.mit.edu	37	chr7	72985181	72985181	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggagagggccaggcggcacgGcgcggcacccgccgcctctt	5	3	17	16	6	1	1	0	0	1	1	1	2	1	1	4	6	0	2	4	6	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:72985181G>A	uc003tyh.2	-	7	1134	c.1000C>T	c.(1000-1002)CCG>TCG	p.P334S	TBL2_uc011kex.1_Missense_Mutation_p.P298S|TBL2_uc010lbg.2_Missense_Mutation_p.P239S|TBL2_uc003tyi.2_Missense_Mutation_p.P169S|TBL2_uc011key.1_Missense_Mutation_p.P205S|TBL2_uc010lbh.2_Missense_Mutation_p.P239S	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	334	WD 6.										0		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGGCGGCACGGCGCGGCACCC	0.602													20	87					0	0	0	0	A	72985181	A	A	72985181	3	1	276	1	0	0	0	0	1	0	0	0	15708	1203	42	4	347	4	TBL2	7	72985181	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1496428	72985181	86153482	742	50631											
EIF4H	7458	broad.mit.edu	37	chr7	73604022	73604022	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggattctgctatgtagaattCgatgaagtggattcccttaa	11	14	10	6	1	1	2	0	1	1	1	3	5	2	4	1	2	1	2	1	2	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:73604022C>T	uc003uad.1	+	3	275	c.267C>T	c.(265-267)TTC>TTT	p.F89F	RFC2_uc011kfa.1_Intron|EIF4H_uc011kfg.1_Silent_p.F89F|EIF4H_uc010lbm.2_Silent_p.F89F|EIF4H_uc003uae.1_Silent_p.F89F|EIF4H_uc003uaf.1_RNA|MIR590_hsa-mir-590|MI0003602_5'Flank	NM_022170	NP_071496	Q15056	IF4H_HUMAN	eukaryotic translation initiation factor 4H	89	RRM.				interspecies interaction between organisms|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0						ATGTAGAATTCGATGAAGTGG	0.408													8	44					0	0	0	0	T	73604022	T	T	73604022	2	4	276	1	0	0	0	0	0	0	0	1	5063	883	31	1		1	EIF4H	7	73604022	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	618841	73604022	85534641	743	50632											
NCF1	653361	broad.mit.edu	37	chr7	74193715	74193715	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atctcccgctgtccccacctCctcgacttcttcaaggtgcg	5	11	7	18	3	3	0	1	0	2	0	7	1	5	0	5	1	1	1	5	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:74193715C>T	uc003ubb.2	+	4	412	c.342C>T	c.(340-342)CTC>CTT	p.L114L	NCF1_uc010lbs.1_Silent_p.L114L|NCF1_uc011kfh.1_Intron	NM_000265	NP_000256	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	114	PX.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			skin(1)	1						GTCCCCACCTCCTCGACTTCT	0.522													6	50					0	0	0	0	T	74193715	T	T	74193715	2	4	276	1	0	0	0	0	0	0	0	1	10270	842	30	2		2	NCF1	7	74193715	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	589693	74193715	84944948	744	50633											
HIP1	3092	broad.mit.edu	37	chr7	75203141	75203141	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caagatgacctggatcagcgGggcgaggcggcactgccctg	8	5	16	12	3	1	2	1	1	0	1	1	4	1	3	2	5	2	1	2	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:75203141G>A	uc003uds.1	-	8	711	c.670C>T	c.(670-672)CCG>TCG	p.P224S	HIP1_uc011kfz.1_Missense_Mutation_p.P101S	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	224					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						TGGATCAGCGGGGCGAGGCGG	0.547			T	PDGFRB	CMML								28	48					0	0	0	0	A	75203141	A	A	75203141	3	1	276	1	0	0	0	0	1	0	0	0	7153	1232	43	4	2539	4	HIP1	7	75203141	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1009426	75203141	83935522	745	50634											
MDH2	4191	broad.mit.edu	37	chr7	75687336	75687336	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aatgccacgattgtggccacCctgaccgctgcctgtgccca	7	8	10	16	2	0	1	0	1	0	0	0	2	0	1	6	1	3	1	6	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:75687336C>T	uc003ueo.2	+	4	455	c.369C>T	c.(367-369)ACC>ACT	p.T123T	MDH2_uc003uep.2_Silent_p.T16T|MDH2_uc011kgh.1_Silent_p.T123T	NM_005918	NP_005909	P40926	MDHM_HUMAN	mitochondrial malate dehydrogenase precursor	123					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					NADH(DB00157)	TTGTGGCCACCCTGACCGCTG	0.557													9	45					0	0	0	0	T	75687336	T	T	75687336	2	4	276	1	0	0	0	0	0	0	0	1	9463	610	22	4		4	MDH2	7	75687336	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	484195	75687336	83451327	746	50635											
SRCRB4D	136853	broad.mit.edu	37	chr7	76019433	76019433	+	Nonsense_Mutation	SNP	C	T	T																															tggtcacagttgtgggcatcCcagcggatatgagagcagag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:76019433C>T	uc003ufb.2	-	11	2019	c.1671G>A	c.(1669-1671)TGG>TGA	p.W557*	SRCRB4D_uc003ufa.2_Missense_Mutation_p.G59E	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	557	SRCR 4.					extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						TGTGGGCATCCCAGCGGATAT	0.602													9	98					0	0	0	0	T	76019433	T	T	76019433	4	4	276	1	0	0	0	0	0	1	0	0	15203	624	22	4	60	4	SRCRB4D	7	76019433	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	332097	76019433	83119230	747	50636	113	2									
SRCRB4D	136853	broad.mit.edu	37	chr7	76019439	76019439	+	Silent	SNP	G	A	A																															cagttgtgggcatcccagcgGatatgagagcagagcagcag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:76019439G>A	uc003ufb.2	-	11	2013	c.1665C>T	c.(1663-1665)ATC>ATT	p.I555I	SRCRB4D_uc003ufa.2_Missense_Mutation_p.S57F	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	555	SRCR 4.					extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						CATCCCAGCGGATATGAGAGC	0.612													9	96					0	0	0	0	A	76019439	A	A	76019439	2	1	276	1	0	0	0	0	0	0	0	1	15203	1164	41	2		2	SRCRB4D	7	76019439	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6	76019439	83119224	748	50637	113	2									
POMZP3	22932	broad.mit.edu	37	chr7	76240831	76240831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacgacacgaggctgcctcCtggaatggcttggagtgcca	8	8	13	12	2	1	0	1	0	0	0	2	4	2	2	3	4	2	2	3	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:76240831C>T	uc003uft.2	-	6	1262	c.515G>A	c.(514-516)AGG>AAG	p.R172K	uc003ufs.1_Intron|POMZP3_uc003ufu.2_Intron|POMZP3_uc003ufv.2_RNA|POMZP3_uc011kgm.1_RNA	NM_012230	NP_036362	Q6PJE2	POZP3_HUMAN	POMZP3 fusion protein isoform 1	172											0		Myeloproliferative disorder(862;0.204)				AGGCTGCCTCCTGGAATGGCT	0.537													17	19					0	0	0	0	T	76240831	T	T	76240831	3	4	276	1	0	0	0	0	1	0	0	0	12302	681	24	4	59	4	POMZP3	7	76240831	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	221392	76240831	82897832	749	50638											
MAGI2	9863	broad.mit.edu	37	chr7	78636502	78636502	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taagttgaggtagtgacgaaGgtctttatcaacaattcctc	12	13	9	7	1	2	2	1	2	1	0	4	3	3	2	1	2	1	2	1	2	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:78636502G>A	uc003ugx.2	-	2	576	c.322C>T	c.(322-324)CTT>TTT	p.L108F	MAGI2_uc003ugy.2_Missense_Mutation_p.L108F	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	108						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TAGTGACGAAGGTCTTTATCA	0.378													10	63					0	0	0	0	A	78636502	A	A	78636502	3	1	276	1	0	0	0	0	1	0	0	0	9244	1000	35	4	4129	4	MAGI2	7	78636502	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2395671	78636502	80502161	750	50639											
HGF	3082	broad.mit.edu	37	chr7	81381476	81381476	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacagacttcgtagcgtacCtctggattgcttgtgaaaca	10	12	9	10	2	2	2	1	1	1	1	3	3	2	3	1	1	4	3	1	1	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:81381476C>T	uc003uhl.2	-	5	750	c.585G>A	c.(583-585)GAG>GAA	p.E195E	HGF_uc003uhm.2_Silent_p.E190E|HGF_uc003uhn.1_Silent_p.E195E|HGF_uc003uho.1_Silent_p.E190E|HGF_uc003uhp.2_Silent_p.E195E	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	195	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						CGTAGCGTACCTCTGGATTGC	0.473													33	69					0	0	0	0	T	81381476	T	T	81381476	2	4	276	1	0	0	0	0	0	0	0	1	7124	680	24	4		4	HGF	7	81381476	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2744974	81381476	77757187	751	50640											
HGF	3082	broad.mit.edu	37	chr7	81381563	81381563	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtaggtctttaccccgataGctcgaaggcaaaaagctagt	12	10	10	9	2	1	0	0	0	1	0	2	2	1	0	2	2	3	4	2	2	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:81381563G>A	uc003uhl.2	-	5	663	c.498C>T	c.(496-498)AGC>AGT	p.S166S	HGF_uc003uhm.2_Silent_p.S161S|HGF_uc003uhn.1_Silent_p.S166S|HGF_uc003uho.1_Silent_p.S161S|HGF_uc003uhp.2_Silent_p.S166S	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	166	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						TACCCCGATAGCTCGAAGGCA	0.398													8	74					0	0	0	0	A	81381563	A	A	81381563	2	1	276	1	0	0	0	0	0	0	0	1	7124	985	34	4		4	HGF	7	81381563	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	87	81381563	77757100	752	50641											
PCLO	27445	broad.mit.edu	37	chr7	82544738	82544738	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgatttcttatgctttgaCtgcttttgataaagtatggc	9	18	9	5	0	1	3	0	3	1	0	1	3	1	3	0	1	2	3	0	1	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:82544738C>A	uc003uhx.2	-	7	12853	c.12564G>T	c.(12562-12564)CAG>CAT	p.Q4188H	PCLO_uc003uhv.2_Missense_Mutation_p.Q4188H|PCLO_uc010lec.2_Missense_Mutation_p.Q1153H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4119					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TATGCTTTGACTGCTTTTGAT	0.348													28	61					2.65835e-16	2.75054e-16	1	0	A	82544738	A	A	82544738	3	1	276	1	0	0	0	0	1	0	0	0	11637	564	20	4	2957	4	PCLO	7	82544738	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1163175	82544738	76593925	753	50642											
PCLO	27445	broad.mit.edu	37	chr7	82544869	82544869	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatggtaataatgagaaaGaccagcaaggtgatctaagc	17	7	11	6	0	1	3	0	2	1	2	1	4	1	3	1	2	3	3	1	2	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:82544869G>T	uc003uhx.2	-	7	12722	c.12433C>A	c.(12433-12435)CTT>ATT	p.L4145I	PCLO_uc003uhv.2_Missense_Mutation_p.L4145I|PCLO_uc010lec.2_Missense_Mutation_p.L1110I	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4076					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TAATGAGAAAGACCAGCAAGG	0.398													26	128					1.13719e-10	1.16522e-10	1	0	T	82544869	T	T	82544869	3	4	276	1	0	0	0	0	1	0	0	0	11637	942	33	2	3088	2	PCLO	7	82544869	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	131	82544869	76593794	754	50643											
PCLO	27445	broad.mit.edu	37	chr7	82545878	82545878	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcctttaatagggcctctttCctcctgttaattcccatttc	6	18	4	13	0	1	0	0	0	1	0	6	0	5	0	5	1	0	1	5	1	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:82545878C>T	uc003uhx.2	-	7	11713	c.11424G>A	c.(11422-11424)AGG>AGA	p.R3808R	PCLO_uc003uhv.2_Silent_p.R3808R|PCLO_uc010lec.2_Silent_p.R773R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3739					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGGCCTCTTTCCTCCTGTTAA	0.448													12	74					0	0	0	0	T	82545878	T	T	82545878	2	4	276	1	0	0	0	0	0	0	0	1	11637	854	30	2		2	PCLO	7	82545878	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1009	82545878	76592785	755	50644											
PCLO	27445	broad.mit.edu	37	chr7	82586136	82586136	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcagttggaataagacttGgaatttcaccaagtgagctt	13	12	9	7	0	2	2	2	1	0	1	2	4	2	4	1	2	1	2	1	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:82586136G>A	uc003uhx.2	-	5	4422	c.4133C>T	c.(4132-4134)CCA>CTA	p.P1378L	PCLO_uc003uhv.2_Missense_Mutation_p.P1378L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1309					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AATAAGACTTGGAATTTCACC	0.448													7	69					0	0	0	0	A	82586136	A	A	82586136	3	1	276	1	0	0	0	0	1	0	0	0	11637	1348	47	4	11396	4	PCLO	7	82586136	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	40258	82586136	76552527	756	50645											
SEMA3A	10371	broad.mit.edu	37	chr7	83636728	83636728	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccattgatagttgggtcCatccctgtgggcatatggac	8	11	11	11	0	0	1	0	1	0	0	2	2	2	2	3	3	0	2	3	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:83636728C>T	uc003uhz.2	-	10	1396	c.1081G>A	c.(1081-1083)GGA>AGA	p.G361R		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	361	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TAGTTGGGTCCATCCCTGTGG	0.433													15	117					0	0	0	0	T	83636728	T	T	83636728	3	4	276	1	0	0	0	0	1	0	0	0	14089	603	21	4	1266	4	SEMA3A	7	83636728	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1050592	83636728	75501935	757	50646											
DMTF1	9988	broad.mit.edu	37	chr7	86803936	86803936	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atggaagcaggggatgtggtCcaaggaagaaattgatattt	14	10	14	3	0	0	2	0	1	0	1	1	5	1	5	1	5	1	1	1	5	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:86803936C>T	uc003uih.2	+	7	796	c.470C>T	c.(469-471)TCC>TTC	p.S157F	DMTF1_uc003uii.2_5'UTR|DMTF1_uc003uij.2_5'UTR|DMTF1_uc011khb.1_Missense_Mutation_p.S69F|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Missense_Mutation_p.S157F|DMTF1_uc003uim.1_Missense_Mutation_p.S157F|DMTF1_uc003uin.2_5'UTR	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	157	Required for transcriptional activation (By similarity).|Interaction with CCND2 (By similarity).|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					GGGATGTGGTCCAAGGAAGAA	0.299													28	56					0	0	0	0	T	86803936	T	T	86803936	3	4	276	1	0	0	0	0	1	0	0	0	4614	855	30	2	488	2	DMTF1	7	86803936	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3167208	86803936	72334727	758	50647											
RUNDC3B	154661	broad.mit.edu	37	chr7	87459342	87459342	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccaggcctaactccatcCtgaaaatttttgtgtaaaag	13	12	7	9	0	0	1	0	1	0	0	3	1	3	1	4	1	1	1	4	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:87459342C>T	uc003ujb.2	+	12	1830	c.1419C>T	c.(1417-1419)TCC>TCT	p.S473S	RUNDC3B_uc011khe.1_Silent_p.S456S|RUNDC3B_uc003ujc.2_Silent_p.S407S|RUNDC3B_uc003ujd.2_Silent_p.S329S	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	473										skin(1)	1	Esophageal squamous(14;0.00164)					TAACTCCATCCTGAAAATTTT	0.348													9	75					0	0	0	0	T	87459342	T	T	87459342	2	4	276	1	0	0	0	0	0	0	0	1	13810	668	24	4		4	RUNDC3B	7	87459342	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	655406	87459342	71679321	759	50648											
ZNF804B	219578	broad.mit.edu	37	chr7	88963669	88963669	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacaccactcttcaatggcCtacggaacttctgctcttta	9	12	5	15	1	4	0	1	0	3	0	4	1	4	1	3	2	3	1	3	2	4	5	rs150650174		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:88963669C>T	uc011khi.1	+	4	1911	c.1373C>T	c.(1372-1374)CCT>CTT	p.P458L		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	458						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CTTCAATGGCCTACGGAACTT	0.423										HNSCC(36;0.09)			14	98					0	0	0	0	T	88963669	T	T	88963669	3	4	276	1	0	0	0	0	1	0	0	0	18238	681	24	4	1387	4	ZNF804B	7	88963669	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1504327	88963669	70174994	760	50649											
AKAP9	10142	broad.mit.edu	37	chr7	91632538	91632538	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaaagaactcaatgtacttAaatcagaacaggtatgttta	18	11	7	5	0	2	3	2	0	0	3	2	3	2	3	0	1	3	3	0	1	9	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:91632538A>T	uc003ulg.2	+	8	3532	c.3307A>T	c.(3307-3309)AAA>TAA	p.K1103*	AKAP9_uc003ule.2_Nonsense_Mutation_p.K1115*|AKAP9_uc003ulf.2_Nonsense_Mutation_p.K1103*|AKAP9_uc003uli.2_Nonsense_Mutation_p.K728*	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1115	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAATGTACTTAAATCAGAACA	0.318			T	BRAF	papillary thyroid								26	59					0	0	0	0	T	91632538	T	T	91632538	4	4	276	1	0	0	0	0	0	1	0	0	459	363	13	5	3337	5	AKAP9	7	91632538	Nonsense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	2668869	91632538	67506125	761	50650											
ANKIB1	54467	broad.mit.edu	37	chr7	91972502	91972502	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cacgctcttctgtcacctccCcagatgaaatcagcttatct	9	12	5	15	1	5	2	2	1	3	1	6	2	6	2	3	0	1	2	3	0	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:91972502C>T	uc003ulw.2	+	6	1328	c.952C>T	c.(952-954)CCA>TCA	p.P318S		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	318							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TGTCACCTCCCCAGATGAAAT	0.448													10	27					0	0	0	0	T	91972502	T	T	91972502	3	4	276	1	0	0	0	0	1	0	0	0	630	623	22	4	970	4	ANKIB1	7	91972502	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	339964	91972502	67166161	762	50651											
COL1A2	1278	broad.mit.edu	37	chr7	94034999	94034999	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctaagggtgctcgtggtttCcctggaactcctggacttcc	5	13	11	12	1	1	0	0	0	1	0	5	2	4	2	3	4	2	2	3	4	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:94034999C>T	uc003ung.1	+	11	972	c.501C>T	c.(499-501)TTC>TTT	p.F167F	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfh.1_RNA	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	167					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CTCGTGGTTTCCCTGGAACTC	0.378										HNSCC(75;0.22)			23	141					0	0	0	0	T	94034999	T	T	94034999	2	4	276	1	0	0	0	0	0	0	0	1	3693	854	30	2		2	COL1A2	7	94034999	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2062497	94034999	65103664	763	50652											
PPP1R9A	55607	broad.mit.edu	37	chr7	94919528	94919528	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaacaaagagaaaagctaagGagaaaggagcaagagcaaat	24	2	11	4	0	0	3	0	0	0	3	0	6	0	4	0	2	4	3	0	2	8	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:94919528G>A	uc003unp.2	+	16	3492	c.3210G>A	c.(3208-3210)AGG>AGA	p.R1070R	PPP1R9A_uc010lfj.2_Silent_p.R1346R|PPP1R9A_uc011kif.1_Silent_p.R1268R|PPP1R9A_uc003unq.2_Silent_p.R1225R|PPP1R9A_uc011kig.1_Silent_p.R1062R|PPP1R9A_uc003unr.2_Silent_p.R359R	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	1070	Potential.|Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAAAGCTAAGGAGAAAGGAGC	0.448										HNSCC(28;0.073)			4	27					0	0	0	0	A	94919528	A	A	94919528	2	1	276	1	0	0	0	0	0	0	0	1	12438	1165	41	2		2	PPP1R9A	7	94919528	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	884529	94919528	64219135	764	50653											
NPTX2	4885	broad.mit.edu	37	chr7	98257804	98257804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accgcgtccttcgcgcacaaGaaattgtcaacatcgccaac	12	7	7	15	5	1	1	1	0	0	1	4	1	2	1	3	0	2	1	3	0	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:98257804G>A	uc003upl.2	+	5	1336	c.1159G>A	c.(1159-1161)GAA>AAA	p.E387K		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	387	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			TCGCGCACAAGAAATTGTCAA	0.572													4	12					0	0	0	0	A	98257804	A	A	98257804	3	1	276	1	0	0	0	0	1	0	0	0	10657	943	33	2	1177	2	NPTX2	7	98257804	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3338276	98257804	60880859	765	50654											
TRRAP	8295	broad.mit.edu	37	chr7	98501139	98501139	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctcaccacagagctgagaaaCcgtacgtccagcctgtcttg	10	8	9	14	2	2	2	1	1	1	2	3	3	3	2	4	0	4	2	4	0	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:98501139C>T	uc003upp.2	+	12	1244	c.1035C>T	c.(1033-1035)AAC>AAT	p.N345N	TRRAP_uc011kis.1_Silent_p.N345N|TRRAP_uc003upr.2_Silent_p.N37N	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	345					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGCTGAGAAACCGTACGTCCA	0.498													15	105					0	0	0	0	T	98501139	T	T	98501139	2	4	276	1	0	0	0	0	0	0	0	1	16668	521	18	4		4	TRRAP	7	98501139	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	243335	98501139	60637524	766	50655											
CYP3A43	64816	broad.mit.edu	37	chr7	99459380	99459380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggagtgttcattcccaaaGggttagcagtgatggttcca	10	12	12	7	0	1	1	1	1	0	0	3	2	3	2	2	3	1	4	2	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:99459380G>A	uc003urx.1	+	11	1274	c.1171G>A	c.(1171-1173)GGG>AGG	p.G391R	CYP3A43_uc003ury.1_Missense_Mutation_p.G391R|CYP3A43_uc003urz.1_Missense_Mutation_p.G391R|CYP3A43_uc003usa.1_RNA|CYP3A43_uc010lgi.1_Missense_Mutation_p.G281R|CYP3A43_uc003usb.1_Missense_Mutation_p.G251R	NM_057095	NP_476436	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	391			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	CATTCCCAAAGGGTTAGCAGT	0.453													25	104					0	0	0	0	A	99459380	A	A	99459380	3	1	276	1	0	0	0	0	1	0	0	0	4196	1000	35	4	1213	4	CYP3A43	7	99459380	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	958241	99459380	59679283	767	50656											
MCM7	4176	broad.mit.edu	37	chr7	99696750	99696750	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gattccacgcacagttaccaActtccccacagagtcagccc	11	7	6	17	1	1	1	1	0	0	1	3	2	3	1	5	0	3	2	5	0	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:99696750A>G	uc003usw.1	-	5	988	c.478T>C	c.(478-480)TTG>CTG	p.L160L	MCM7_uc003usv.1_5'UTR|MCM7_uc003usx.1_5'UTR|AP4M1_uc011kjg.1_5'Flank|AP4M1_uc010lgl.1_5'Flank|AP4M1_uc003utb.3_5'Flank|AP4M1_uc003utc.3_5'Flank|AP4M1_uc010lgm.2_5'Flank|AP4M1_uc003utd.2_5'Flank|AP4M1_uc011kjh.1_5'Flank|AP4M1_uc003ute.3_5'Flank|AP4M1_uc003utf.3_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	160					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	ACAGTTACCAACTTCCCCACA	0.527													34	54					0	0	0	0	G	99696750	G	G	99696750	2	3	276	1	0	0	0	0	0	0	0	1	9445	40	2	5		5	MCM7	7	99696750	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	237370	99696750	59441913	768	50657											
ZCWPW1	55063	broad.mit.edu	37	chr7	99998661	99998661	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttcccaaacagcgccacgggGaagtcctcgccatcactgtt	9	8	9	15	3	1	0	1	0	0	0	4	1	3	1	4	2	2	1	4	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:99998661G>A	uc003uut.2	-	18	2171	c.1923C>T	c.(1921-1923)TTC>TTT	p.F641F	ZCWPW1_uc011kjq.1_Silent_p.F521F|ZCWPW1_uc003uur.2_3'UTR|ZCWPW1_uc003uus.2_Silent_p.F470F|ZCWPW1_uc011kjr.1_3'UTR|ZCWPW1_uc011kjp.1_RNA	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	641							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCGCCACGGGGAAGTCCTCGC	0.597													6	35					0	0	0	0	A	99998661	A	A	99998661	2	1	276	1	0	0	0	0	0	0	0	1	17664	1165	41	2		2	ZCWPW1	7	99998661	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	301911	99998661	59140002	769	50658											
C7orf47	221908	broad.mit.edu	37	chr7	100033362	100033362	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggctcaccaggtcccggaaGagccgcttggagcgcggcac	8	4	15	14	4	1	1	1	0	0	1	2	3	2	3	3	5	2	3	3	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:100033362G>A	uc003uuy.1	-	3	577	c.480C>T	c.(478-480)CTC>CTT	p.L160L	C7orf47_uc003uux.1_Silent_p.L58L	NM_145030	NP_659467	Q8TAP8	CG047_HUMAN	hypothetical protein LOC221908	160										ovary(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGTCCCGGAAGAGCCGCTTGG	0.632													6	12					0	0	0	0	A	100033362	A	A	100033362	2	1	276	1	0	0	0	0	0	0	0	1	2408	929	33	2		2	C7orf47	7	100033362	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	34701	100033362	59105301	770	50659											
FBXO24	26261	broad.mit.edu	37	chr7	100189332	100189332	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcatttggaggccgccgccGatgtctcagcaagagcgtgg	7	7	16	11	4	1	1	1	0	1	1	2	3	1	2	3	4	2	2	3	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:100189332G>A	uc003uvm.1	+	4	658	c.365G>A	c.(364-366)CGA>CAA	p.R122Q	FBXO24_uc010lha.1_RNA|FBXO24_uc003uvl.1_Missense_Mutation_p.R108Q|FBXO24_uc003uvn.1_5'UTR|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Missense_Mutation_p.R160Q|FBXO24_uc011kka.1_Missense_Mutation_p.R110Q	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	122						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GGCCGCCGCCGATGTCTCAGC	0.582													13	81					0	0	0	0	A	100189332	A	A	100189332	3	1	276	1	0	0	0	0	1	0	0	0	5767	1058	37	1	536	1	FBXO24	7	100189332	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	155970	100189332	58949331	771	50660											
ZAN	7455	broad.mit.edu	37	chr7	100350374	100350375	+	Missense_Mutation	DNP	GG	AA	AA																															gaaaaactcaccatccccacGgaaaaacccaccatccccat																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:100350374_100350375GG>AA	uc003uwj.2	+	14	2811_2812	c.2646_2647GG>AA	c.(2644-2649)ACGGAA>ACAAAA	p.E883K	ZAN_uc003uwk.2_Missense_Mutation_p.E883K|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	883	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCATCCCCACGGAAAAACCCAC	0.505													28	98					0	0	0	0	AA	100350375	AA	AA	100350374	3	1	276	1	0	0	0	0	1	0	0	0	17581	1103	39	1	2696	1	ZAN	7	100350374	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	161042	100350374	58788289	772	50661											
MUC17	140453	broad.mit.edu	37	chr7	100677450	100677450	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taccagcatgccaacctcaaCtcctggggaaggaagcactc	12	6	9	14	0	1	0	1	0	0	0	3	2	2	2	4	3	6	2	4	3	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:100677450C>T	uc003uxp.1	+	3	2806	c.2753C>T	c.(2752-2754)ACT>ATT	p.T918I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	918	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|13.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAACCTCAACTCCTGGGGAA	0.507													40	791					0	0	0	0	T	100677450	T	T	100677450	3	4	276	1	0	0	0	0	1	0	0	0	10027	565	20	4	2763	4	MUC17	7	100677450	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	327076	100677450	58461213	773	50662											
MUC17	140453	broad.mit.edu	37	chr7	100677989	100677989	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgccaacctcaacttatagtGaaggaagcactccactaaca	15	8	6	12	0	1	1	1	1	0	0	2	2	2	2	3	1	5	1	3	1	7	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:100677989G>A	uc003uxp.1	+	3	3345	c.3292G>A	c.(3292-3294)GAA>AAA	p.E1098K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1098	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|16.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTTATAGTGAAGGAAGCAC	0.517													79	777					0	0	0	0	A	100677989	A	A	100677989	3	1	276	1	0	0	0	0	1	0	0	0	10027	1291	45	2	3302	2	MUC17	7	100677989	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	539	100677989	58460674	774	50663											
MUC17	140453	broad.mit.edu	37	chr7	100678973	100678973	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcctgttgacaccagcaccCctgggaccacttctgctgaa	8	9	8	16	0	1	2	0	2	1	0	2	3	2	3	5	1	2	3	5	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:100678973C>T	uc003uxp.1	+	3	4329	c.4276C>T	c.(4276-4278)CCT>TCT	p.P1426S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1426	Extracellular (Potential).|Ser-rich.|22.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACCAGCACCCCTGGGACCAC	0.498													102	433					0	0	0	0	T	100678973	T	T	100678973	3	4	276	1	0	0	0	0	1	0	0	0	10027	623	22	4	4286	4	MUC17	7	100678973	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	984	100678973	58459690	775	50664											
MUC17	140453	broad.mit.edu	37	chr7	100680999	100680999	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagctcctagtgaaggaaGtcctctactaacaagtatac	13	10	7	11	0	2	1	1	1	1	0	4	2	4	2	2	1	4	2	2	1	8	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:100680999G>A	uc003uxp.1	+	3	6355	c.6302G>A	c.(6301-6303)AGT>AAT	p.S2101N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2101	Extracellular (Potential).|33.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGTGAAGGAAGTCCTCTACTA	0.507													50	292					0	0	0	0	A	100680999	A	A	100680999	3	1	276	1	0	0	0	0	1	0	0	0	10027	1029	36	4	6312	4	MUC17	7	100680999	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2026	100680999	58457664	776	50665											
CUX1	1523	broad.mit.edu	37	chr7	101891804	101891804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccgggcggcgcccagctcgGagggcgacagctgcgacggc	5	2	19	15	7	0	0	0	0	0	0	1	3	0	1	2	5	3	2	2	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:101891804G>A	uc003uyx.3	+	24	4038	c.4000G>A	c.(4000-4002)GAG>AAG	p.E1334K	CUX1_uc003uys.3_Missense_Mutation_p.E1345K|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	1334					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GCCCAGCTCGGAGGGCGACAG	0.721													3	11					0	0	0	0	A	101891804	A	A	101891804	3	1	276	1	0	0	0	0	1	0	0	0	4081	1175	41	2	4161	2	CUX1	7	101891804	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1210805	101891804	57246859	777	50666											
LHFPL3	375612	broad.mit.edu	37	chr7	104377334	104377334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaagacagcttgatggcaGaggaactgaaggcagaaaac	17	4	13	7	0	0	5	0	2	0	3	0	7	0	6	0	3	3	3	0	3	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:104377334G>A	uc003vce.2	+	2	782	c.658G>A	c.(658-660)GAG>AAG	p.E220K	LHFPL3_uc003vcf.2_Missense_Mutation_p.E220K	NM_199000	NP_945351	Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	206						integral to membrane					0						CTTGATGGCAGAGGAACTGAA	0.443													3	20					0	0	0	0	A	104377334	A	A	104377334	3	1	276	1	0	0	0	0	1	0	0	0	8807	943	33	2	664	2	LHFPL3	7	104377334	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2485530	104377334	54761329	778	50667											
LAMB1	3912	broad.mit.edu	37	chr7	107603364	107603364	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttacctgtggctcgtagcGaattaggatgtcgtactcca	8	13	10	10	3	0	0	0	0	0	0	3	2	1	1	2	2	3	3	2	2	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:107603364G>A	uc003vew.2	-	15	2178	c.1843C>T	c.(1843-1845)CGC>TGC	p.R615C	LAMB1_uc003vev.2_Missense_Mutation_p.R639C|LAMB1_uc003vex.2_Missense_Mutation_p.R615C|LAMB1_uc010ljn.1_Missense_Mutation_p.R701C	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	615	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCTCGTAGCGAATTAGGATG	0.453													16	100					0	0	0	0	A	107603364	A	A	107603364	3	1	276	1	0	0	0	0	1	0	0	0	8650	1058	37	1	3597	1	LAMB1	7	107603364	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3226030	107603364	51535299	779	50668											
NRCAM	4897	broad.mit.edu	37	chr7	107836218	107836218	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tacttaccactcgatggttgGgagaggagacccaaagaagg	13	7	13	8	1	0	3	0	0	0	3	1	6	0	3	2	4	2	1	2	4	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:107836218G>A	uc003vfb.2	-	15	1921	c.1450C>T	c.(1450-1452)CCA>TCA	p.P484S	NRCAM_uc003vfc.2_Missense_Mutation_p.P478S|NRCAM_uc011kmk.1_Missense_Mutation_p.P479S|NRCAM_uc003vfd.2_Missense_Mutation_p.P460S|NRCAM_uc003vfe.2_Missense_Mutation_p.P460S	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	484	Ig-like 5.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TCGATGGTTGGGAGAGGAGAC	0.423													4	23					0	0	0	0	A	107836218	A	A	107836218	3	1	276	1	0	0	0	0	1	0	0	0	10698	1232	43	4	2570	4	NRCAM	7	107836218	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	232854	107836218	51302445	780	50669											
IFRD1	3475	broad.mit.edu	37	chr7	112108061	112108061	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttttatgaagacatggagtCcttgacgcagatgcttaggg	10	13	12	6	1	0	4	0	2	0	2	1	5	1	5	1	2	1	2	1	2	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:112108061C>T	uc003vgh.2	+	10	1375	c.932C>T	c.(931-933)TCC>TTC	p.S311F	IFRD1_uc011kmn.1_Missense_Mutation_p.S261F|IFRD1_uc003vgj.2_Missense_Mutation_p.S311F|IFRD1_uc011kmo.1_RNA|IFRD1_uc011kmp.1_Missense_Mutation_p.S261F|IFRD1_uc003vgk.2_Missense_Mutation_p.S28F	NM_001007245	NP_001007246	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	311					multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2						GACATGGAGTCCTTGACGCAG	0.408													7	51					0	0	0	0	T	112108061	T	T	112108061	3	4	276	1	0	0	0	0	1	0	0	0	7592	855	30	2	966	2	IFRD1	7	112108061	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4271843	112108061	47030602	781	50670											
FOXP2	93986	broad.mit.edu	37	chr7	114284804	114284805	+	Missense_Mutation	DNP	GG	AA	AA																															atggagtttgcaaatggccaGgctgtgaaagcatttgtgaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:114284804_114284805GG>AA	uc003vhb.2	+	8	1428_1429	c.1054_1055GG>AA	c.(1054-1056)GGC>AAC	p.G352N	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.G377N|FOXP2_uc003vha.2_Missense_Mutation_p.G260N|FOXP2_uc011kmu.1_Missense_Mutation_p.G369N|FOXP2_uc011kmv.1_Missense_Mutation_p.G351N|FOXP2_uc010ljz.1_Missense_Mutation_p.G260N|FOXP2_uc003vgx.2_Missense_Mutation_p.G352N|FOXP2_uc003vhd.2_Missense_Mutation_p.G352N|FOXP2_uc003vhc.2_Missense_Mutation_p.G377N	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	352	C2H2-type.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						CAAATGGCCAGGCTGTGAAAGC	0.455													13	49					0	0	0	0	AA	114284805	AA	AA	114284804	3	1	276	1	0	0	0	0	1	0	0	0	6061	1000	35	4	1214	4	FOXP2	7	114284804	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	2176743	114284804	44853859	782	50671											
ST7	7982	broad.mit.edu	37	chr7	116759690	116759690	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtaagccacttgcgccccCttctgggaggggttgacaac	8	8	12	13	1	1	1	0	1	1	0	1	2	1	2	3	3	3	2	3	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:116759690C>T	uc003vin.2	+	3	524	c.310C>T	c.(310-312)CTT>TTT	p.L104F	ST7_uc011knl.1_Missense_Mutation_p.L104F|ST7_uc003vio.2_Missense_Mutation_p.L104F|ST7_uc003viq.2_Missense_Mutation_p.L58F|ST7_uc011knm.1_Missense_Mutation_p.L61F|ST7_uc003vir.2_Missense_Mutation_p.L52F|ST7OT2_uc003viu.2_Intron|ST7_uc011knn.1_Missense_Mutation_p.L52F|ST7OT2_uc003viw.2_Intron|ST7_uc003vix.1_5'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	104						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CTTGCGCCCCCTTCTGGGAGG	0.418													18	109					0	0	0	0	T	116759690	T	T	116759690	3	4	276	1	0	0	0	0	1	0	0	0	15295	681	24	4	320	4	ST7	7	116759690	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2474886	116759690	42378973	783	50672											
KCND2	3751	broad.mit.edu	37	chr7	120373073	120373073	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gattgtatccaacttcagtcGcatctaccaccagaatcaac	13	10	5	13	1	3	1	2	0	1	1	5	2	4	1	3	0	3	2	3	0	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:120373073G>T	uc003vjj.1	+	2	2197	c.1232G>T	c.(1231-1233)CGC>CTC	p.R411L		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	411	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					AACTTCAGTCGCATCTACCAC	0.458													21	56					9.62636e-23	1.00092e-22	1	0	T	120373073	T	T	120373073	3	4	276	1	0	0	0	0	1	0	0	0	8058	1087	38	3	1238	3	KCND2	7	120373073	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3613383	120373073	38765590	784	50673											
ING3	54556	broad.mit.edu	37	chr7	120608018	120608018	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taataattccacagcctcttCtaacaatgcctacaatgtga	14	12	4	11	0	2	1	0	1	2	0	3	1	3	1	3	0	4	0	3	0	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:120608018C>T	uc003vjn.2	+	8	721	c.587C>T	c.(586-588)TCT>TTT	p.S196F	ING3_uc003vjo.2_5'UTR|ING3_uc003vjp.2_Missense_Mutation_p.S196F|ING3_uc011kns.1_Missense_Mutation_p.S181F	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	196					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					ACAGCCTCTTCTAACAATGCC	0.388													11	119					0	0	0	0	T	120608018	T	T	120608018	3	4	276	1	0	0	0	0	1	0	0	0	7776	913	32	2	633	2	ING3	7	120608018	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	234945	120608018	38530645	785	50674											
C7orf58	79974	broad.mit.edu	37	chr7	120782185	120782185	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgaggccttcacagcatgtgGttttgtgcaggtaagtgaag	9	12	14	6	0	1	2	1	2	0	0	1	2	1	2	1	3	2	4	1	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:120782185G>A	uc003vjq.3	+	16	2492	c.2045G>A	c.(2044-2046)GGT>GAT	p.G682D	C7orf58_uc003vjs.3_Missense_Mutation_p.G682D|C7orf58_uc003vjt.3_Missense_Mutation_p.G462D	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	682						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					ACAGCATGTGGTTTTGTGCAG	0.438													43	93					0	0	0	0	A	120782185	A	A	120782185	3	1	276	1	0	0	0	0	1	0	0	0	2416	1261	44	4	2103	4	C7orf58	7	120782185	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	174167	120782185	38356478	786	50675											
PTPRZ1	5803	broad.mit.edu	37	chr7	121695040	121695041	+	Frame_Shift_Ins	INS	-	AT	AT																															aaataaagatgagcctataaINSattgtgagagctttaaggtc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:121695040_121695041insAT	uc003vjy.2	+	27	6822_6823	c.6427_6428insAT	c.(6427-6429)AATfs	p.N2143fs	PTPRZ1_uc003vjz.2_Frame_Shift_Ins_p.N1276fs|PTPRZ1_uc011knt.1_Frame_Shift_Ins_p.N733fs	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	2143	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity	p.C2143F(1)		ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TGAGCCTATAAATTGTGAGAGC	0.332													---	---	---								AT	121695041	AT	AT	121695040	7	5	276	1	0	1	1	0	0	0	0	0	12879	14	1	0	6533	0	PTPRZ1	7	121695040	Frame_Shift_Ins	INS	-	TCGA-D6-6516-01A-11D-1870-08	912855	121695040	37443623	787	50676											
LMOD2	442721	broad.mit.edu	37	chr7	123302483	123302483	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcgagtccaacttcataacGggaaaggggatcctggccat	11	8	12	10	2	1	0	1	0	0	0	4	3	3	2	3	4	2	0	3	4	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:123302483G>A	uc003vky.2	+	2	1000	c.843G>A	c.(841-843)ACG>ACA	p.T281T		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	281						cytoskeleton	actin binding|tropomyosin binding				0						ACTTCATAACGGGAAAGGGGA	0.552													32	43					0	0	0	0	A	123302483	A	A	123302483	2	1	276	1	0	0	0	0	0	0	0	1	8899	1103	39	1		1	LMOD2	7	123302483	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1607443	123302483	35836180	788	50677											
GRM8	2918	broad.mit.edu	37	chr7	126086395	126086395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgaagcacttaaactcatgGagacagtaagtgttgttgtc	12	12	10	7	0	1	2	1	1	0	1	2	3	1	2	0	1	2	4	0	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:126086395G>A	uc003vlr.2	-	9	2773	c.2462C>T	c.(2461-2463)TCC>TTC	p.S821F	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.S821F|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	821	Helical; Name=7; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TAAACTCATGGAGACAGTAAG	0.368										HNSCC(24;0.065)			11	37					0	0	0	0	A	126086395	A	A	126086395	3	1	276	1	0	0	0	0	1	0	0	0	6842	1174	41	2	322	2	GRM8	7	126086395	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2783912	126086395	33052268	789	50678											
GRM8	2918	broad.mit.edu	37	chr7	126410011	126410011	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatgtatccagggcagagaTctttgtgcatattgtgcagg	10	12	12	7	0	1	1	0	0	1	1	2	2	2	1	1	2	2	4	1	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:126410011T>A	uc003vlr.2	-	6	1576	c.1265A>T	c.(1264-1266)GAT>GTT	p.D422V	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.D422V|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.D143V	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	422	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AGGGCAGAGATCTTTGTGCAT	0.413										HNSCC(24;0.065)			18	60					0	0	0	0	A	126410011	A	A	126410011	3	1	276	1	0	0	0	0	1	0	0	0	6842	1435	50	5	1531	5	GRM8	7	126410011	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	323616	126410011	32728652	790	50679											
GRM8	2918	broad.mit.edu	37	chr7	126410053	126410053	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgtaagccatggaatatacaGcatcaattacaaattggacc	16	9	7	9	1	1	0	1	0	0	0	1	2	1	2	2	2	4	2	2	2	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:126410053G>A	uc003vlr.2	-	6	1534	c.1223C>T	c.(1222-1224)GCT>GTT	p.A408V	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.A408V|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.A129V	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	408	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GGAATATACAGCATCAATTAC	0.423										HNSCC(24;0.065)			13	37					0	0	0	0	A	126410053	A	A	126410053	3	1	276	1	0	0	0	0	1	0	0	0	6842	971	34	4	1573	4	GRM8	7	126410053	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	42	126410053	32728610	791	50680											
CCDC136	64753	broad.mit.edu	37	chr7	128446882	128446882	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagcacctcagggatacGgtggcctccttcaaagagag	10	7	12	12	1	2	1	2	0	0	1	3	3	3	2	3	3	3	2	3	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:128446882G>A	uc003vnv.1	+	9	1756	c.1389G>A	c.(1387-1389)ACG>ACA	p.T463T	CCDC136_uc003vnu.1_Intron|CCDC136_uc003vnw.1_Silent_p.T410T|CCDC136_uc003vnx.1_Silent_p.T279T|CCDC136_uc010llq.1_5'UTR|CCDC136_uc003vny.1_Silent_p.T73T	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	463						integral to membrane	protein binding			ovary(2)	2						TCAGGGATACGGTGGCCTCCT	0.552													9	17					0	0	0	0	A	128446882	A	A	128446882	2	1	276	1	0	0	0	0	0	0	0	1	2782	1103	39	1		1	CCDC136	7	128446882	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2036829	128446882	30691781	792	50681											
FLNC	2318	broad.mit.edu	37	chr7	128480173	128480173	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttcaaggtgtttaccaaggGtgccggcagcggggagctca	8	8	15	10	2	2	0	2	0	0	0	2	1	2	1	2	5	4	3	2	5	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:128480173G>A	uc003vnz.3	+	9	1717	c.1508G>A	c.(1507-1509)GGT>GAT	p.G503D	FLNC_uc003voa.3_Missense_Mutation_p.G503D	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	503	Filamin 3.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TTTACCAAGGGTGCCGGCAGC	0.637													52	90					0	0	0	0	A	128480173	A	A	128480173	3	1	276	1	0	0	0	0	1	0	0	0	5967	1261	44	4	1542	4	FLNC	7	128480173	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	33291	128480173	30658490	793	50682											
IRF5	3663	broad.mit.edu	37	chr7	128582178	128582178	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcccaccccaccccgccgcGtgcggctgaagccctggctg	4	5	11	21	4	0	1	0	1	0	0	1	1	1	1	7	2	2	2	7	2	1	0	rs142800920		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:128582178G>A	uc003vog.2	+	2	164	c.43G>A	c.(43-45)GTG>ATG	p.V15M	IRF5_uc010llr.1_Missense_Mutation_p.V15M|IRF5_uc011kot.1_Missense_Mutation_p.V15M|IRF5_uc011kou.1_Missense_Mutation_p.V15M|IRF5_uc010lls.1_Missense_Mutation_p.V15M|IRF5_uc003voh.2_Missense_Mutation_p.V15M|IRF5_uc010llt.2_Missense_Mutation_p.V15M|IRF5_uc003voi.2_Missense_Mutation_p.V15M|IRF5_uc010llu.1_Missense_Mutation_p.V15M|IRF5_uc003vok.2_Missense_Mutation_p.V15M|IRF5_uc003voj.3_Missense_Mutation_p.V15M|IRF5_uc010llv.1_Missense_Mutation_p.V15M|IRF5_uc010llw.1_Missense_Mutation_p.V15M	NM_002200	NP_002191	Q13568	IRF5_HUMAN	interferon regulatory factor 5 isoform a	15	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						ACCCCGCCGCGTGCGGCTGAA	0.622													11	60					0	0	0	0	A	128582178	A	A	128582178	3	1	276	1	0	0	0	0	1	0	0	0	7872	1145	40	1	45	1	IRF5	7	128582178	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	102005	128582178	30556485	794	50683											
PODXL	5420	broad.mit.edu	37	chr7	131190752	131190752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaagcggtcctcggcctcctCcggtggcccctggtccccta	3	8	12	18	3	0	0	0	0	0	0	5	1	4	0	8	5	1	0	8	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:131190752C>T	uc003vqw.3	-	8	1612	c.1354G>A	c.(1354-1356)GAG>AAG	p.E452K	PODXL_uc003vqx.3_Missense_Mutation_p.E420K	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	podocalyxin-like isoform 1 precursor	452	Extracellular (Potential).				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)					TCGGCCTCCTCCGGTGGCCCC	0.647													4	24					0	0	0	0	T	131190752	T	T	131190752	3	4	276	1	0	0	0	0	1	0	0	0	12235	864	30	2	330	2	PODXL	7	131190752	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2608574	131190752	27947911	795	50684											
PODXL	5420	broad.mit.edu	37	chr7	131196154	131196154	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gacactggatgctggagtcgGtgctgttttgttagatgagt	7	14	15	5	1	0	2	0	1	0	1	1	5	0	4	0	3	2	4	0	3	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:131196154G>A	uc003vqw.3	-	2	397	c.139C>T	c.(139-141)CCG>TCG	p.P47S	PODXL_uc003vqx.3_Missense_Mutation_p.P47S	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	podocalyxin-like isoform 1 precursor	47	Thr-rich.|Extracellular (Potential).				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)					GCTGGAGTCGGTGCTGTTTTG	0.527													27	109					0	0	0	0	A	131196154	A	A	131196154	3	1	276	1	0	0	0	0	1	0	0	0	12235	1261	44	4	1569	4	PODXL	7	131196154	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5402	131196154	27942509	796	50685											
PLXNA4	91584	broad.mit.edu	37	chr7	131866195	131866195	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggattcctgagggaccaaagGcctcaaacaccgggttggga	11	6	14	10	1	1	1	1	1	0	0	2	4	2	4	4	5	1	1	4	5	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:131866195G>T	uc003vra.3	-	18	3666	c.3437C>A	c.(3436-3438)GCC>GAC	p.A1146D		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1146	IPT/TIG 4.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GGGACCAAAGGCCTCAAACAC	0.582													57	115					1.00798e-23	1.0485e-23	1	0	T	131866195	T	T	131866195	3	4	276	1	0	0	0	0	1	0	0	0	12177	1203	42	4	2307	4	PLXNA4	7	131866195	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	670041	131866195	27272468	797	50686											
LRGUK	136332	broad.mit.edu	37	chr7	133812343	133812343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctatcaggagctggactcgGacggagatgaggaccagggc	10	5	17	9	2	1	2	1	1	0	1	2	7	1	6	1	6	1	2	1	6	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:133812343G>A	uc003vrm.1	+	1	239	c.223G>A	c.(223-225)GAC>AAC	p.D75N		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	75							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						GCTGGACTCGGACGGAGATGA	0.597													9	56					0	0	0	0	A	133812343	A	A	133812343	3	1	276	1	0	0	0	0	1	0	0	0	8993	1174	41	2	225	2	LRGUK	7	133812343	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1946148	133812343	25326320	798	50687											
CNOT4	4850	broad.mit.edu	37	chr7	135123021	135123021	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgatatcatctatctccaagGgctccatgcaaagagggcac	12	9	9	11	0	3	2	1	1	2	1	5	2	4	2	2	2	1	3	2	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:135123021G>A	uc003vsv.1	-	2	366	c.59C>T	c.(58-60)CCC>CTC	p.P20L	CNOT4_uc003vss.2_Missense_Mutation_p.P20L|CNOT4_uc011kpz.1_Missense_Mutation_p.P20L|CNOT4_uc003vst.2_Missense_Mutation_p.P20L|CNOT4_uc003vsu.1_Missense_Mutation_p.P20L|CNOT4_uc011kpy.1_Missense_Mutation_p.P20L	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	20	RING-type; degenerate.				nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						TATCTCCAAGGGCTCCATGCA	0.433													16	33					0	0	0	0	A	135123021	A	A	135123021	3	1	276	1	0	0	0	0	1	0	0	0	3636	1232	43	4	2005	4	CNOT4	7	135123021	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1310678	135123021	24015642	799	50688											
NUP205	23165	broad.mit.edu	37	chr7	135292093	135292093	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagtggcggtgcgagaatctCctcagctggctgagctatgt	7	10	14	10	2	2	2	1	1	1	1	3	3	2	2	1	3	3	3	1	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:135292093C>T	uc003vsw.2	+	22	3200	c.3169C>T	c.(3169-3171)CCT>TCT	p.P1057S		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1057					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GCGAGAATCTCCTCAGCTGGC	0.502													10	44					0	0	0	0	T	135292093	T	T	135292093	3	4	276	1	0	0	0	0	1	0	0	0	10813	855	30	2	3255	2	NUP205	7	135292093	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	169072	135292093	23846570	800	50689											
DGKI	9162	broad.mit.edu	37	chr7	137154314	137154314	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	accatctaggaagcaccaccGaggagagagcctctgtgctg	11	6	12	12	1	2	1	0	0	2	1	2	5	2	3	4	2	3	2	4	2	2	1	rs150062419		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:137154314G>C	uc003vtt.2	-	25	2480	c.2479C>G	c.(2479-2481)CGG>GGG	p.R827G	DGKI_uc003vtu.2_Missense_Mutation_p.R527G	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	827					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						AAGCACCACCGAGGAGAGAGC	0.522													26	56					0	0	0	0	C	137154314	C	C	137154314	3	2	276	1	0	0	0	0	1	0	0	0	4493	1057	37	3	758	3	DGKI	7	137154314	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1862221	137154314	21984349	801	50690											
TRPV6	55503	broad.mit.edu	37	chr7	142570156	142570156	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcggtctcccaggccatactCccgtccgcagatcccggagc	6	6	11	18	4	1	1	0	0	1	1	5	2	4	2	5	3	2	1	5	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:142570156C>T	uc003wbx.1	-	14	2080	c.1864G>A	c.(1864-1866)GAG>AAG	p.E622K	TRPV6_uc003wbw.1_Missense_Mutation_p.E408K|TRPV6_uc010lou.1_Missense_Mutation_p.E493K	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	622	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					AGGCCATACTCCCGTCCGCAG	0.627													7	29					0	0	0	0	T	142570156	T	T	142570156	3	4	276	1	0	0	0	0	1	0	0	0	16667	864	30	2	321	2	TRPV6	7	142570156	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5415842	142570156	16568507	802	50691											
TRPV6	55503	broad.mit.edu	37	chr7	142574508	142574508	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttacccagggagtcctgggcCcggatgtcagctccatgctc	6	9	12	14	1	1	0	1	0	0	0	4	2	3	2	4	3	3	2	4	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:142574508C>T	uc003wbx.1	-	5	786	c.570G>A	c.(568-570)CGG>CGA	p.R190R	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_Silent_p.R61R	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	190	ANK 4.|Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					AGTCCTGGGCCCGGATGTCAG	0.607													22	58					0	0	0	0	T	142574508	T	T	142574508	2	4	276	1	0	0	0	0	0	0	0	1	16667	610	22	4		4	TRPV6	7	142574508	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4352	142574508	16564155	803	50692											
OR6V1	346517	broad.mit.edu	37	chr7	142749631	142749631	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttcttcctgggcaatttttCcctgctggagatcttggtaa	6	16	9	10	0	2	1	0	0	2	1	4	2	4	1	2	3	1	3	2	3	2	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:142749631C>T	uc011ksv.1	+	1	194	c.194C>T	c.(193-195)TCC>TTC	p.S65F		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					GGCAATTTTTCCCTGCTGGAG	0.493													105	176					0	0	0	0	T	142749631	T	T	142749631	3	4	276	1	0	0	0	0	1	0	0	0	11265	855	30	2	196	2	OR6V1	7	142749631	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	175123	142749631	16389032	804	50693											
FAM131B	9715	broad.mit.edu	37	chr7	143053832	143053832	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctcctcctcagcagggccCcttgccaggtccactgcgcc	4	9	9	19	1	2	0	1	0	1	0	5	0	4	0	7	2	3	1	7	2	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:143053832C>T	uc003wct.2	-	6	2516	c.810G>A	c.(808-810)AGG>AGA	p.R270R	FAM131B_uc010loz.2_Silent_p.R238R|FAM131B_uc003wcu.3_Silent_p.R270R|FAM131B_uc010lpa.2_Silent_p.R298R	NM_014690	NP_055505	Q86XD5	F131B_HUMAN	hypothetical protein LOC9715 isoform b	270											0	Melanoma(164;0.205)					CAGCAGGGCCCCTTGCCAGGT	0.627													30	144					0	0	0	0	T	143053832	T	T	143053832	2	4	276	1	0	0	0	0	0	0	0	1	5468	622	22	4		4	FAM131B	7	143053832	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	304201	143053832	16084831	805	50694											
ZYX	7791	broad.mit.edu	37	chr7	143085984	143085984	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcccgccccctggagggcaCctccttcatcgtggaccagg	5	6	12	18	3	1	0	1	0	0	0	3	2	2	2	6	4	0	1	6	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:143085984C>T	uc003wcw.2	+	8	1594	c.1439C>T	c.(1438-1440)ACC>ATC	p.T480I	ZYX_uc011ktd.1_Missense_Mutation_p.T323I|ZYX_uc003wcx.2_Missense_Mutation_p.T480I|ZYX_uc011kte.1_Missense_Mutation_p.T449I|ZYX_uc011ktf.1_Missense_Mutation_p.T323I	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	480	LIM zinc-binding 2.				cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					CTGGAGGGCACCTCCTTCATC	0.667													13	86					0	0	0	0	T	143085984	T	T	143085984	3	4	276	1	0	0	0	0	1	0	0	0	18321	507	18	4	1465	4	ZYX	7	143085984	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	32152	143085984	16052679	806	50695											
TAS2R60	338398	broad.mit.edu	37	chr7	143140716	143140716	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgttgttgccttgtgataaGttattggttagcctaggggc	7	16	13	5	0	0	1	0	1	0	0	0	1	0	1	2	3	2	4	2	3	4	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:143140716G>A	uc011ktg.1	+	1	171	c.171G>A	c.(169-171)AAG>AAA	p.K57K	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	57	Helical; Name=2; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					CTTGTGATAAGTTATTGGTTA	0.498													35	69					0	0	0	0	A	143140716	A	A	143140716	2	1	276	1	0	0	0	0	0	0	0	1	15651	1020	36	4		4	TAS2R60	7	143140716	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	54732	143140716	15997947	807	50696											
TAS2R60	338398	broad.mit.edu	37	chr7	143141134	143141134	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaattctatctcttccctCtaaaaatgattacttggaca	14	14	4	9	0	3	2	0	1	3	1	5	3	4	3	1	1	1	0	1	1	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:143141134C>T	uc011ktg.1	+	1	589	c.589C>T	c.(589-591)CTA>TTA	p.L197L	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	197	Helical; Name=5; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					TCTCTTCCCTCTAAAAATGAT	0.418													62	155					0	0	0	0	T	143141134	T	T	143141134	2	4	276	1	0	0	0	0	0	0	0	1	15651	912	32	2		2	TAS2R60	7	143141134	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	418	143141134	15997529	808	50697											
FAM115A	9747	broad.mit.edu	37	chr7	143573412	143573412	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttttggccaaaggtgccaggGatgggtgtacaccaatggga	10	9	15	7	0	0	0	0	0	0	0	0	2	0	2	3	5	2	1	3	5	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:143573412G>A	uc003wdo.1	-	2	423	c.290C>T	c.(289-291)TCC>TTC	p.S97F	FAM115A_uc011ktu.1_Intron|FAM115A_uc003wdp.1_Missense_Mutation_p.S97F	NM_014719	NP_055534	Q9Y4C2	F115A_HUMAN	hypothetical protein LOC9747	97											0	Melanoma(164;0.0903)					AGGTGCCAGGGATGGGTGTAC	0.562													19	77					0	0	0	0	A	143573412	A	A	143573412	3	1	276	1	0	0	0	0	1	0	0	0	5433	1174	41	2	2507	2	FAM115A	7	143573412	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	432278	143573412	15565251	809	50698											
CNTNAP2	26047	broad.mit.edu	37	chr7	146825806	146825806	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taacctttggaggcatccctTtctctggcaagcccagctcc	7	11	8	15	0	1	0	0	0	1	0	4	1	3	1	4	3	3	3	4	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:146825806T>A	uc003weu.1	+	7	1477	c.961T>A	c.(961-963)TTC>ATC	p.F321I		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	321	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AGGCATCCCTTTCTCTGGCAA	0.393										HNSCC(39;0.1)			18	108					0	0	0	0	A	146825806	A	A	146825806	3	1	276	1	0	0	0	0	1	0	0	0	3662	1841	64	5	987	5	CNTNAP2	7	146825806	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	3252394	146825806	12312857	810	50699											
CNTNAP2	26047	broad.mit.edu	37	chr7	148112610	148112610	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	accataccaacgaagcaaagGgggcggagtcggcagagagc	14	2	15	10	3	0	1	0	0	0	1	1	4	0	2	2	4	4	2	2	4	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:148112610G>A	uc003weu.1	+	24	4414	c.3898G>A	c.(3898-3900)GGG>AGG	p.G1300R	CNTNAP2_uc003wev.1_Missense_Mutation_p.G77R	NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1300	Cytoplasmic (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CGAAGCAAAGGGGGCGGAGTC	0.542										HNSCC(39;0.1)			13	73					0	0	0	0	A	148112610	A	A	148112610	3	1	276	1	0	0	0	0	1	0	0	0	3662	1232	43	4	3992	4	CNTNAP2	7	148112610	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1286804	148112610	11026053	811	50700											
ZNF282	8427	broad.mit.edu	37	chr7	148909480	148909480	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttctgcccaggacctcttgtCccggattaaacaggaggagc	9	9	11	12	1	2	0	0	0	2	0	3	4	3	4	3	4	3	0	3	4	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:148909480C>T	uc003wfm.2	+	6	1088	c.983C>T	c.(982-984)TCC>TTC	p.S328F	ZNF282_uc011kun.1_Missense_Mutation_p.S328F|ZNF282_uc003wfn.2_Missense_Mutation_p.S268F|ZNF282_uc003wfo.2_Intron	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	328					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		GACCTCTTGTCCCGGATTAAA	0.468													10	26					0	0	0	0	T	148909480	T	T	148909480	3	4	276	1	0	0	0	0	1	0	0	0	17886	855	30	2	1005	2	ZNF282	7	148909480	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	796870	148909480	10229183	812	50701											
SSPO	23145	broad.mit.edu	37	chr7	149477972	149477972	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgatgggcggagctactcCttctggggtggtcaaggttg	5	12	16	8	2	2	0	1	0	1	0	4	2	3	1	1	6	2	2	1	6	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:149477972C>T	uc010lpk.2	+	13	1743	c.1743C>T	c.(1741-1743)TCC>TCT	p.S581S	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	581	VWFD 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGAGCTACTCCTTCTGGGGTG	0.677													6	39					0	0	0	0	T	149477972	T	T	149477972	2	4	276	1	0	0	0	0	0	0	0	1	15255	668	24	4		4	SSPO	7	149477972	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	568492	149477972	9660691	813	50702											
SSPO	23145	broad.mit.edu	37	chr7	149494381	149494381	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccattccacagccaagacCctggccctctcctctgccca	7	9	5	20	0	2	1	0	0	2	1	5	1	4	1	7	1	2	0	7	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:149494381C>T	uc010lpk.2	+	47	6852	c.6852C>T	c.(6850-6852)ACC>ACT	p.T2284T		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2284					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGCCAAGACCCTGGCCCTCT	0.662													6	52					0	0	0	0	T	149494381	T	T	149494381	2	4	276	1	0	0	0	0	0	0	0	1	15255	610	22	4		4	SSPO	7	149494381	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	16409	149494381	9644282	814	50703											
ACTR3C	653857	broad.mit.edu	37	chr7	149986643	149986643	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aatatctctacctgcaatcgGgatgtgtttgatgcagcttc	9	14	9	9	1	1	1	0	1	1	0	4	2	1	2	1	1	4	4	1	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:149986643G>A	uc003wgu.1	-	4	383	c.193C>T	c.(193-195)CCG>TCG	p.P65S		NM_001040135	NP_001035225	Q9C0K3	ARP3C_HUMAN	actin-related protein 3-beta isoform 2	65					regulation of actin filament polymerization	cytoskeleton	actin binding|ATP binding				0						CCTGCAATCGGGATGTGTTTG	0.498													7	27					0	0	0	0	A	149986643	A	A	149986643	3	1	276	1	0	0	0	0	1	0	0	0	214	1232	43	4	455	4	ACTR3C	7	149986643	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	492262	149986643	9152020	815	50704											
GIMAP1	170575	broad.mit.edu	37	chr7	150417539	150417539	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcctaaaatggatggtcatCgtcttcaccaggaaggagga	12	9	12	8	1	3	0	2	0	1	0	5	4	4	4	2	5	0	0	2	5	3	2	rs150494282	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:150417539C>T	uc003whq.2	+	3	534	c.447C>T	c.(445-447)ATC>ATT	p.I149I	GIMAP1_uc003whp.2_Silent_p.I157I	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	149	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGATGGTCATCGTCTTCACCA	0.642													8	70					0	0	0	0	T	150417539	T	T	150417539	2	4	276	1	0	0	0	0	0	0	0	1	6416	874	31	1		1	GIMAP1	7	150417539	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	430896	150417539	8721124	816	50705											
ABP1	26	broad.mit.edu	37	chr7	150554746	150554746	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gactgcccggagaccgccacCttcctggacactttccacta	8	8	8	17	2	0	1	0	0	0	1	2	4	2	2	6	2	1	0	6	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:150554746C>T	uc003why.1	+	3	5406	c.1188C>T	c.(1186-1188)ACC>ACT	p.T396T	ABP1_uc003whz.1_Silent_p.T396T|ABP1_uc003wia.1_Silent_p.T396T	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	396					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	AGACCGCCACCTTCCTGGACA	0.627													16	97					0	0	0	0	T	150554746	T	T	150554746	2	4	276	1	0	0	0	0	0	0	0	1	98	668	24	4		4	ABP1	7	150554746	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	137207	150554746	8583917	817	50706											
KCNH2	3757	broad.mit.edu	37	chr7	150654554	150654554	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgaggtcggagtccgaggtgGagttgagcaagccgctgcgc	7	6	18	10	5	0	1	0	1	0	0	2	5	1	3	2	4	3	3	2	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:150654554G>A	uc003wic.2	-	5	966	c.953C>T	c.(952-954)TCC>TTC	p.S318F	KCNH2_uc003wib.2_5'Flank|KCNH2_uc011kux.1_Missense_Mutation_p.S222F|KCNH2_uc003wid.2_5'Flank|KCNH2_uc003wie.2_Missense_Mutation_p.S318F	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	318	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GTCCGAGGTGGAGTTGAGCAA	0.642													7	33					0	0	0	0	A	150654554	A	A	150654554	3	1	276	1	0	0	0	0	1	0	0	0	8071	1174	41	2	2951	2	KCNH2	7	150654554	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	99808	150654554	8484109	818	50707											
FASTK	10922	broad.mit.edu	37	chr7	150774982	150774982	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtaccactgatgtagttgatGaagccaggggaaaaaacaaa	17	7	11	6	0	0	3	0	3	0	0	0	4	0	4	2	2	3	3	2	2	7	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:150774982G>A	uc003wix.1	-	5	1121	c.1023C>T	c.(1021-1023)TTC>TTT	p.F341F	uc011kvf.1_5'Flank|FASTK_uc003wiw.1_Silent_p.F102F|FASTK_uc003wiy.1_Silent_p.F200F|FASTK_uc003wiz.1_Silent_p.F314F|FASTK_uc003wja.1_3'UTR	NM_006712	NP_006703	Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase isoform 1	341					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(2)|stomach(2)	4			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		TGTAGTTGATGAAGCCAGGGG	0.622													8	55					0	0	0	0	A	150774982	A	A	150774982	2	1	276	1	0	0	0	0	0	0	0	1	5716	1281	45	2		2	FASTK	7	150774982	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	120428	150774982	8363681	819	50708											
CHPF2	54480	broad.mit.edu	37	chr7	150934782	150934783	+	Missense_Mutation	DNP	CC	TT	TT																															agcacggggcatggagtacaCcctggacctgctgttggaat																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:150934782_150934783CC>TT	uc003wjr.1	+	4	2847_2848	c.1334_1335CC>TT	c.(1333-1335)ACC>ATT	p.T445I	CHPF2_uc003wjq.1_Missense_Mutation_p.T437I|MIR671_hsa-mir-671|MI0003760_5'Flank	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	445	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						ATGGAGTACACCCTGGACCTGC	0.658													12	62					0	0	0	0	TT	150934783	TT	TT	150934782	3	4	276	1	0	0	0	0	1	0	0	0	3384	507	18	4	1348	4	CHPF2	7	150934782	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	159800	150934782	8203881	820	50709											
WDR86	349136	broad.mit.edu	37	chr7	151093194	151093194	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttgcggtggccccggaactCccgggacatctgccccttgt	4	9	13	15	3	1	0	0	0	1	0	2	2	2	2	5	4	3	1	5	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:151093194C>T	uc003wkb.2	-	3	843	c.394G>A	c.(394-396)GAG>AAG	p.E132K	WDR86_uc003wka.2_Missense_Mutation_p.E90K|WDR86_uc011kvk.1_Missense_Mutation_p.E132K|WDR86_uc003wkc.2_Missense_Mutation_p.E4K	NM_198285	NP_938026	Q86TI4	WDR86_HUMAN	WD repeat domain 86	132	WD 3.										0			OV - Ovarian serous cystadenocarcinoma(82;0.00419)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCCGGAACTCCCGGGACATC	0.677													8	35					0	0	0	0	T	151093194	T	T	151093194	3	4	276	1	0	0	0	0	1	0	0	0	17402	864	30	2	752	2	WDR86	7	151093194	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	158412	151093194	8045469	821	50710											
MLL3	58508	broad.mit.edu	37	chr7	151874263	151874263	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcaagttctggatctgtatAtgcaatgatatcaaactctc	12	14	7	8	0	5	1	2	1	3	0	6	2	5	2	0	1	2	3	0	1	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:151874263A>C	uc003wla.2	-	38	8494	c.8275T>G	c.(8275-8277)TAT>GAT	p.Y2759D	MLL3_uc003wkz.2_Missense_Mutation_p.Y1820D|MLL3_uc003wky.2_Missense_Mutation_p.Y268D	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2759	Asp-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGATCTGTATATGCAATGATA	0.368			N		medulloblastoma								43	70					0	0	0	0	C	151874263	C	C	151874263	3	2	276	1	0	0	0	0	1	0	0	0	9675	449	16	5	6548	5	MLL3	7	151874263	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	781069	151874263	7264400	822	50711											
DPP6	1804	broad.mit.edu	37	chr7	154598806	154598806	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agccatagcatggacttcttCctgctcaagtgcgaaggtca	10	10	10	11	1	3	0	2	0	1	0	4	2	4	1	2	2	4	2	2	2	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:154598806C>T	uc003wlk.2	+	16	1779	c.1650C>T	c.(1648-1650)TTC>TTT	p.F550F	DPP6_uc003wli.2_Silent_p.F486F|DPP6_uc003wlm.2_Silent_p.F488F|DPP6_uc011kvq.1_Silent_p.F443F	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	550	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TGGACTTCTTCCTGCTCAAGT	0.602													24	101					0	0	0	0	T	154598806	T	T	154598806	2	4	276	1	0	0	0	0	0	0	0	1	4752	854	30	2		2	DPP6	7	154598806	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2724543	154598806	4539857	823	50712											
WDR60	55112	broad.mit.edu	37	chr7	158672676	158672676	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgagcccaggaaaagggaatCccaggtaccccttctgatgc	11	7	11	12	0	1	2	0	2	1	0	2	4	2	4	4	3	3	1	4	3	4	2	rs17856461		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr7:158672676C>T	uc003woe.3	+	5	1033	c.875C>T	c.(874-876)TCC>TTC	p.S292F	WDR60_uc010lqv.2_RNA	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	292				S -> F (in Ref. 2; AAH14491).						ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		AAAAGGGAATCCCAGGTACCC	0.527													10	51					0	0	0	0	T	158672676	T	T	158672676	3	4	276	1	0	0	0	0	1	0	0	0	17379	855	30	2	893	2	WDR60	7	158672676	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4073870	158672676	465987	824	50713											
MYOM2	9172	broad.mit.edu	37	chr8	2021531	2021531	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcctgtacaccctgcgcatCgtgtctcggggcggcgtcag	4	8	15	14	5	2	0	1	0	1	0	4	0	2	0	2	4	2	2	2	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:2021531C>T	uc003wpx.3	+	10	1209	c.1071C>T	c.(1069-1071)ATC>ATT	p.I357I	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	357	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CCCTGCGCATCGTGTCTCGGG	0.627													23	35					0	0	0	0	T	2021531	T	T	2021531	2	4	276	1	0	0	0	0	0	0	0	1	10145	874	31	1		1	MYOM2	8	2021531	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08		2021531	144342491	825	50714											
CSMD1	64478	broad.mit.edu	37	chr8	2830813	2830813	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cggatcaccacagaatccagGattatttcctattgaaaaca	15	10	6	10	1	1	2	1	1	0	1	3	4	3	4	3	2	1	0	3	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:2830813G>A	uc011kwk.1	-	57	9142	c.8752C>T	c.(8752-8754)CCT>TCT	p.P2918S	CSMD1_uc011kwj.1_Missense_Mutation_p.P2247S|CSMD1_uc010lrg.2_Missense_Mutation_p.P928S	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2918	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAGAATCCAGGATTATTTCCT	0.428													87	160					0	0	0	0	A	2830813	A	A	2830813	3	1	276	1	0	0	0	0	1	0	0	0	3961	1174	41	2	2001	2	CSMD1	8	2830813	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	809282	2830813	143533209	826	50715											
CSMD1	64478	broad.mit.edu	37	chr8	3019763	3019763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgattttgatgctgttgctgGggagggctggttcttggcat	4	15	16	6	1	1	1	0	1	1	0	1	3	1	2	0	5	2	6	0	5	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:3019763G>A	uc011kwk.1	-	38	6155	c.5765C>T	c.(5764-5766)CCC>CTC	p.P1922L	CSMD1_uc011kwj.1_Missense_Mutation_p.P1314L|CSMD1_uc003wqe.2_Missense_Mutation_p.P1078L|CSMD1_uc010lrg.2_5'UTR	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1922	Sushi 11.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCTGTTGCTGGGGAGGGCTGG	0.458													9	7					0	0	0	0	A	3019763	A	A	3019763	3	1	276	1	0	0	0	0	1	0	0	0	3961	1232	43	4	5064	4	CSMD1	8	3019763	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	188950	3019763	143344259	827	50716											
SGK223	157285	broad.mit.edu	37	chr8	8235533	8235533	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agctgcccaggtagacgacgGgggcatcctcctgcttcggg	6	7	15	13	3	0	1	0	0	0	1	3	2	2	1	3	4	3	4	3	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:8235533G>A	uc003wsh.3	-	2	386	c.386C>T	c.(385-387)CCC>CTC	p.P129L		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	129							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GTAGACGACGGGGGCATCCTC	0.572													27	77					0	0	0	0	A	8235533	A	A	8235533	3	1	276	1	0	0	0	0	1	0	0	0	14275	1232	43	4	3838	4	SGK223	8	8235533	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5215770	8235533	138128489	828	50717											
PPP1R3B	79660	broad.mit.edu	37	chr8	8998678	8998678	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtgtcgaacgtcatccttaTtttcacggtcttctcaaatg	8	15	8	10	3	4	0	3	0	2	0	7	1	5	0	1	2	1	0	1	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:8998678T>A	uc003wsn.3	-	2	649	c.484A>T	c.(484-486)ATA>TTA	p.I162L	PPP1R3B_uc003wso.3_Missense_Mutation_p.I161L	NM_024607	NP_078883	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	162	CBM21.				glycogen metabolic process					ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		GTCATCCTTATTTTCACGGTC	0.512													80	122					0	0	0	0	A	8998678	A	A	8998678	3	1	276	1	0	0	0	0	1	0	0	0	12432	1493	52	5	377	5	PPP1R3B	8	8998678	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	763145	8998678	137365344	829	50718											
RP1L1	94137	broad.mit.edu	37	chr8	10465958	10465958	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacatcttctgactctggctGggcctctccttctgcctctg	3	15	8	15	0	6	1	0	1	6	0	7	1	6	1	3	2	2	1	3	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:10465958G>T	uc003wtc.2	-	4	5879	c.5650C>A	c.(5650-5652)CAG>AAG	p.Q1884K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1884					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GACTCTGGCTGGGCCTCTCCT	0.622													55	303					3.85841e-42	4.02838e-42	1	0	T	10465958	T	T	10465958	3	4	276	1	0	0	0	0	1	0	0	0	13598	1357	47	4	1556	4	RP1L1	8	10465958	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1467280	10465958	135898064	830	50719											
RP1L1	94137	broad.mit.edu	37	chr8	10466645	10466645	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcctcgcagggacagaactCctccccctccgcctcctcgc	5	6	9	21	3	0	1	0	0	0	1	6	2	4	2	7	2	1	1	7	2	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:10466645C>T	uc003wtc.2	-	4	5192	c.4963G>A	c.(4963-4965)GAG>AAG	p.E1655K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1655					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GGACAGAACTCCTCCCCCTCC	0.667													10	61					0	0	0	0	T	10466645	T	T	10466645	3	4	276	1	0	0	0	0	1	0	0	0	13598	864	30	2	2243	2	RP1L1	8	10466645	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	687	10466645	135897377	831	50720											
RP1L1	94137	broad.mit.edu	37	chr8	10470364	10470364	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgccactctctctccctggGaggcatgcaggggattcgtc	5	10	12	14	1	2	0	0	0	2	0	6	2	2	2	2	4	2	2	2	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:10470364G>A	uc003wtc.2	-	4	1473	c.1244C>T	c.(1243-1245)TCC>TTC	p.S415F		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	415					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTCTCCCTGGGAGGCATGCAG	0.677													31	46					0	0	0	0	A	10470364	A	A	10470364	3	1	276	1	0	0	0	0	1	0	0	0	13598	1174	41	2	5962	2	RP1L1	8	10470364	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3719	10470364	135893658	832	50721											
AMAC1L2	83650	broad.mit.edu	37	chr8	11189365	11189365	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccgtgttgcccagtgacctCctgagttggagttgtgtggg	4	12	15	10	1	0	2	0	2	0	0	1	3	1	3	4	2	1	3	4	2	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:11189365C>T	uc003wtp.1	+	1	871	c.750C>T	c.(748-750)CTC>CTT	p.L250L		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	250	Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		CCAGTGACCTCCTGAGTTGGA	0.637													11	106					0	0	0	0	T	11189365	T	T	11189365	2	4	276	1	0	0	0	0	0	0	0	1	560	842	30	2		2	AMAC1L2	8	11189365	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	719001	11189365	135174657	833	50722											
FDFT1	2222	broad.mit.edu	37	chr8	11667353	11667353	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgccaggtgctggaggacttCccaacggtgagtggggttac	7	8	16	10	2	0	1	0	1	0	0	1	3	1	3	2	6	3	2	2	6	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:11667353C>T	uc003wui.2	+	3	527	c.375C>T	c.(373-375)TTC>TTT	p.F125F	FDFT1_uc003wuh.2_Silent_p.F61F|FDFT1_uc010lsa.1_Silent_p.F40F|FDFT1_uc011kxe.1_Silent_p.F61F|FDFT1_uc011kxf.1_Silent_p.F125F|FDFT1_uc011kxg.1_Intron|FDFT1_uc003wuj.2_Silent_p.F118F|FDFT1_uc010lsb.2_Silent_p.F61F|FDFT1_uc011kxh.1_Silent_p.F61F|FDFT1_uc011kxi.1_RNA|FDFT1_uc011kxj.1_Silent_p.F61F|FDFT1_uc003wuk.2_Silent_p.F184F|FDFT1_uc011kxk.1_Silent_p.F40F	NM_004462	NP_004453	P37268	FDFT_HUMAN	squalene synthase	125					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity				0	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		TGGAGGACTTCCCAACGGTGA	0.502													7	31					0	0	0	0	T	11667353	T	T	11667353	2	4	276	1	0	0	0	0	0	0	0	1	5834	854	30	2		2	FDFT1	8	11667353	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	477988	11667353	134696669	834	50723											
MSR1	4481	broad.mit.edu	37	chr8	16026297	16026297	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctcttcgctgtcatttccTtttcccgtgagactttgagt	4	18	7	12	2	2	2	1	2	1	1	6	3	5	2	3	0	0	1	3	0	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:16026297T>A	uc003wwz.2	-	4	498	c.300A>T	c.(298-300)AAA>AAT	p.K100N	MSR1_uc010lsu.2_Missense_Mutation_p.K118N|MSR1_uc003wxa.2_Missense_Mutation_p.K100N|MSR1_uc003wxb.2_Missense_Mutation_p.K100N|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	100	Spacer (Probable).|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TGTCATTTCCTTTTCCCGTGA	0.373													23	135					0	0	0	0	A	16026297	A	A	16026297	3	1	276	1	0	0	0	0	1	0	0	0	9939	1606	56	5	1131	5	MSR1	8	16026297	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	4358944	16026297	130337725	835	50724											
ZDHHC2	51201	broad.mit.edu	37	chr8	17053076	17053076	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caagaggagaagcccatcagGaagttcttaggcgagcagcc	13	5	13	10	1	2	2	1	0	1	2	2	5	2	3	2	3	3	2	2	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:17053076G>A	uc003wxe.2	+	4	713	c.316G>A	c.(316-318)GAA>AAA	p.E106K		NM_016353	NP_057437	Q9UIJ5	ZDHC2_HUMAN	zinc finger, DHHC-type containing 2	106						integral to membrane	acyltransferase activity|zinc ion binding				0				Colorectal(111;0.0697)|COAD - Colon adenocarcinoma(73;0.244)		AGCCCATCAGGAAGTTCTTAG	0.408													13	62					0	0	0	0	A	17053076	A	A	17053076	3	1	276	1	0	0	0	0	1	0	0	0	17677	1175	41	2	330	2	ZDHHC2	8	17053076	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1026779	17053076	129310946	836	50725											
GFRA2	2675	broad.mit.edu	37	chr8	21562583	21562583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cacgacagctgcaccaggggGacaccacgatgccagtgggg	10	3	15	13	2	0	0	0	0	0	0	0	3	0	1	3	4	3	2	3	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:21562583G>A	uc003wzu.1	-	6	1634	c.959C>T	c.(958-960)TCC>TTC	p.S320F	GFRA2_uc003wzv.1_Missense_Mutation_p.S215F|GFRA2_uc003wzw.1_Missense_Mutation_p.S187F	NM_001495	NP_001486	O00451	GFRA2_HUMAN	GDNF family receptor alpha 2 isoform a	320						anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity				0				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		GCACCAGGGGGACACCACGAT	0.592													3	14					0	0	0	0	A	21562583	A	A	21562583	3	1	276	1	0	0	0	0	1	0	0	0	6385	1174	41	2	451	2	GFRA2	8	21562583	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4509507	21562583	124801439	837	50726											
EPB49	2039	broad.mit.edu	37	chr8	21925103	21925103	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atccccaaggacaaggccatCctggacatcgagcggcccga	11	4	11	15	3	0	0	0	0	0	0	3	4	2	2	5	4	1	0	5	4	2	0	rs140385917	by1000genomes	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:21925103C>T	uc011kyt.1	+	4	388	c.159C>T	c.(157-159)ATC>ATT	p.I53I	EPB49_uc010ltl.2_Silent_p.I53I|EPB49_uc011kys.1_Silent_p.I28I|EPB49_uc010ltn.2_Silent_p.I28I|EPB49_uc011kyu.1_Silent_p.I53I|EPB49_uc011kyv.1_Silent_p.I53I|EPB49_uc010ltq.2_Silent_p.I53I	NM_001114136	NP_001107608	Q08495	DEMA_HUMAN	erythrocyte membrane protein band 4.9 isoform 1	53					actin filament bundle assembly|actin filament capping	actin cytoskeleton|nucleus	actin binding			central_nervous_system(1)	1				Colorectal(74;9.05e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0631)		ACAAGGCCATCCTGGACATCG	0.612													13	58					0	0	0	0	T	21925103	T	T	21925103	2	4	276	1	0	0	0	0	0	0	0	1	5183	845	30	2		2	EPB49	8	21925103	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	362520	21925103	124438919	838	50727											
NUDT18	79873	broad.mit.edu	37	chr8	21965715	21965715	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccacggacagcagtgtctcgGgctcacagtgcagccccgcc	7	5	12	17	3	2	0	1	0	1	0	3	1	2	1	4	2	3	3	4	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:21965715G>A	uc003xaq.1	-	5	424	c.305C>T	c.(304-306)CCC>CTC	p.P102L	NUDT18_uc003xar.1_3'UTR	NM_024815	NP_079091	Q6ZVK8	NUD18_HUMAN	nudix (nucleoside diphosphate linked moiety	102	Nudix hydrolase.						hydrolase activity|metal ion binding|protein binding				0				Colorectal(74;0.00185)|COAD - Colon adenocarcinoma(73;0.0608)|READ - Rectum adenocarcinoma(5;0.0986)		CAGTGTCTCGGGCTCACAGTG	0.682													3	16					0	0	0	0	A	21965715	A	A	21965715	3	1	276	1	0	0	0	0	1	0	0	0	10789	1232	43	4	674	4	NUDT18	8	21965715	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	40612	21965715	124398307	839	50728											
SLC39A14	23516	broad.mit.edu	37	chr8	22262322	22262322	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggctcacgcttcatccctGggtgcaccagctatcagcgc	7	8	11	15	2	3	0	3	0	0	0	4	1	4	0	2	2	3	4	2	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:22262322G>A	uc003xbq.3	+	2	274	c.99G>A	c.(97-99)CTG>CTA	p.L33L	SLC39A14_uc011kzg.1_Silent_p.L33L|SLC39A14_uc003xbp.3_Silent_p.L33L|SLC39A14_uc011kzh.1_Silent_p.L33L	NM_001128431	NP_001121903	Q15043	S39AE_HUMAN	solute carrier family 39 (zinc transporter),	33	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity				0				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)		CTTCATCCCTGGGTGCACCAG	0.602													22	105					0	0	0	0	A	22262322	A	A	22262322	2	1	276	1	0	0	0	0	0	0	0	1	14681	1335	47	4		4	SLC39A14	8	22262322	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	296607	22262322	124101700	840	50729											
SLC25A37	51312	broad.mit.edu	37	chr8	23429112	23429113	+	Missense_Mutation	DNP	CC	TT	TT																															cgccgcggccgccacgacccCcctggacgtctgtaagaccc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:23429112_23429113CC>TT	uc003xdo.2	+	4	914_915	c.761_762CC>TT	c.(760-762)CCC>CTT	p.P254L	SLC25A37_uc003xdp.2_RNA|SLC25A37_uc010ltz.2_RNA|SLC25A37_uc003xdq.2_RNA|uc003xds.2_5'Flank	NM_016612	NP_057696	Q9NYZ2	MFRN1_HUMAN	solute carrier family 25, member 37	254	Solcar 3.				ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane					0		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)		GCCACGACCCCCCTGGACGTCT	0.668													3	25					0	0	0	0	TT	23429113	TT	TT	23429112	3	4	276	1	0	0	0	0	1	0	0	0	14565	623	22	4	775	4	SLC25A37	8	23429112	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1166790	23429112	122934910	841	50730											
ADAM7	8756	broad.mit.edu	37	chr8	24324313	24324313	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgttcccaatttctacaggGgattcttcagaataaacgac	12	12	8	9	1	3	1	1	0	2	1	4	3	4	2	1	2	2	1	1	2	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:24324313G>A	uc003xeb.2	+	6	504	c.391G>A	c.(391-393)GGA>AGA	p.G131R	ADAM7_uc003xea.1_Missense_Mutation_p.G131R	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	131	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TTTCTACAGGGGATTCTTCAG	0.378													11	59					0	0	0	0	A	24324313	A	A	24324313	3	1	276	1	0	0	0	0	1	0	0	0	251	1246	43	4	413	4	ADAM7	8	24324313	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	895201	24324313	122039709	842	50731											
ADAM7	8756	broad.mit.edu	37	chr8	24350689	24350689	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaactatttttttataccatGattctacagacattggcctg	12	16	5	8	0	1	2	0	1	1	1	1	2	1	2	2	1	3	0	2	1	5	9			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:24350689G>A	uc003xeb.2	+	16	1902	c.1789G>A	c.(1789-1791)GAT>AAT	p.D597N	ADAM7_uc003xec.2_Missense_Mutation_p.D369N	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	597	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TTTATACCATGATTCTACAGA	0.403													18	36					0	0	0	0	A	24350689	A	A	24350689	3	1	276	1	0	0	0	0	1	0	0	0	251	1290	45	2	1851	2	ADAM7	8	24350689	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	26376	24350689	122013333	843	50732											
SCARA3	51435	broad.mit.edu	37	chr8	27516190	27516190	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caccaccagcagacaaatctCccaggagatgggcagttgct	12	6	10	13	0	1	2	0	0	1	2	2	3	1	2	3	2	2	4	3	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:27516190C>T	uc003xga.1	+	5	644	c.503C>T	c.(502-504)TCC>TTC	p.S168F	SCARA3_uc003xgb.1_Missense_Mutation_p.S168F	NM_016240	NP_057324	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3 isoform 1	168	Extracellular (Potential).				response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			skin(2)|ovary(1)|breast(1)	4		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		AGACAAATCTCCCAGGAGATG	0.612													10	57					0	0	0	0	T	27516190	T	T	27516190	3	4	276	1	0	0	0	0	1	0	0	0	13944	855	30	2	521	2	SCARA3	8	27516190	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3165501	27516190	118847832	844	50733											
C8orf80	389643	broad.mit.edu	37	chr8	27880848	27880848	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggagttacagtgatgtccCgggggggccagccttgctgg	6	8	17	10	1	0	1	0	1	0	0	1	2	1	2	3	5	3	2	3	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:27880848C>T	uc003xgm.3	-	19	2520	c.2377G>A	c.(2377-2379)GGG>AGG	p.G793R		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	793						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		AGTGATGTCCCGGGGGGGCCA	0.493													8	29					0	0	0	0	T	27880848	T	T	27880848	3	4	276	1	0	0	0	0	1	0	0	0	2451	652	23	1	17	1	C8orf80	8	27880848	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	364658	27880848	118483174	845	50734											
EXTL3	2137	broad.mit.edu	37	chr8	28574958	28574958	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggaagtcggtgccgtccCggtggtgctgggggagcagg	4	7	20	10	3	0	0	0	0	0	0	2	2	1	2	3	7	3	2	3	7	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:28574958C>T	uc003xgz.1	+	3	1975	c.1382C>T	c.(1381-1383)CCG>CTG	p.P461L		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	461	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		GGTGCCGTCCCGGTGGTGCTG	0.622													15	32					0	0	0	0	T	28574958	T	T	28574958	3	4	276	1	0	0	0	0	1	0	0	0	5352	652	23	1	1384	1	EXTL3	8	28574958	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	694110	28574958	117789064	846	50735											
UNC5D	137970	broad.mit.edu	37	chr8	35583804	35583804	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cactctttaaccctttgtcgGacatcaaagtgaaagtccag	12	11	7	11	1	2	1	1	1	1	0	4	2	3	2	2	1	1	0	2	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:35583804G>A	uc003xjr.1	+	10	1766	c.1438G>A	c.(1438-1440)GAC>AAC	p.D480N	UNC5D_uc003xjs.1_Missense_Mutation_p.D475N|UNC5D_uc003xju.1_Missense_Mutation_p.D56N|UNC5D_uc003xjt.1_Missense_Mutation_p.D238N	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	480	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCCTTTGTCGGACATCAAAGT	0.522													7	30					0	0	0	0	A	35583804	A	A	35583804	3	1	276	1	0	0	0	0	1	0	0	0	17063	1174	41	2	1476	2	UNC5D	8	35583804	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7008846	35583804	110780218	847	50736											
KCNU1	157855	broad.mit.edu	37	chr8	36644890	36644890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccacttccagggacaatttCgtgatcatatagaaatgttg	12	13	8	8	1	1	2	1	1	0	1	4	3	3	3	2	1	0	1	2	1	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:36644890C>T	uc010lvw.2	+	2	349	c.262C>T	c.(262-264)CGT>TGT	p.R88C	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	88	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GGGACAATTTCGTGATCATAT	0.428													9	24					0	0	0	0	T	36644890	T	T	36644890	3	4	276	1	0	0	0	0	1	0	0	0	8132	884	31	1	268	1	KCNU1	8	36644890	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1061086	36644890	109719132	848	50737											
MYST3	7994	broad.mit.edu	37	chr8	41798814	41798814	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccagcggcccctccgagatGgctggctatttgcaggaaga	8	7	13	13	2	0	2	0	0	0	2	1	4	1	3	4	4	2	3	4	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:41798814G>A	uc010lxb.2	-	16	3129	c.2585C>T	c.(2584-2586)CCA>CTA	p.P862L	MYST3_uc010lxc.2_Missense_Mutation_p.P862L|MYST3_uc003xon.3_Missense_Mutation_p.P862L	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	862					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			CCTCCGAGATGGCTGGCTATT	0.468													17	96					0	0	0	0	A	41798814	A	A	41798814	3	1	276	1	0	0	0	0	1	0	0	0	10157	1348	47	4	3441	4	MYST3	8	41798814	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5153924	41798814	104565208	849	50738											
PLAT	5327	broad.mit.edu	37	chr8	42038041	42038041	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgggcggcagagagaatcCagcaggagctgatgagtatg	12	6	17	6	1	0	4	0	2	0	2	1	6	1	5	1	3	2	4	1	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:42038041C>T	uc003xos.2	-	10	1261	c.1052G>A	c.(1051-1053)TGG>TAG	p.W351*	PLAT_uc010lxf.1_Nonsense_Mutation_p.W268*|PLAT_uc010lxg.1_Nonsense_Mutation_p.W176*|PLAT_uc003xot.2_Nonsense_Mutation_p.W305*|PLAT_uc011lcm.1_Nonsense_Mutation_p.W262*|PLAT_uc011lcn.1_Nonsense_Mutation_p.W225*	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	351	Peptidase S1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AGAGAGAATCCAGCAGGAGCT	0.607													21	86					0	0	0	0	T	42038041	T	T	42038041	4	4	276	1	0	0	0	0	0	1	0	0	12076	595	21	4	656	4	PLAT	8	42038041	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	239227	42038041	104325981	850	50739											
DKK4	27121	broad.mit.edu	37	chr8	42234519	42234519	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccaggaccagagctcccagGggagagcagagccagctcag	11	3	14	13	0	1	3	1	0	0	3	3	5	3	4	4	3	4	3	4	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:42234519G>A	uc003xpb.2	-	1	156	c.45C>T	c.(43-45)CCC>CCT	p.P15P		NM_014420	NP_055235	Q9UBT3	DKK4_HUMAN	dickkopf homolog 4 precursor	15					multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region				ovary(1)	1	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)			GAGCTCCCAGGGGAGAGCAGA	0.657													4	53					0	0	0	0	A	42234519	A	A	42234519	2	1	276	1	0	0	0	0	0	0	0	1	4569	1219	43	4		4	DKK4	8	42234519	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	196478	42234519	104129503	851	50740											
CHRNB3	1142	broad.mit.edu	37	chr8	42585737	42585737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtgtactaatttcatgcagGaatggacagaccacaagtta	15	10	9	7	0	1	1	1	0	0	1	1	3	1	3	1	2	2	3	1	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:42585737G>A	uc003xpi.1	+	4	378	c.250G>A	c.(250-252)GAA>AAA	p.E84K		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	84	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TTTCATGCAGGAATGGACAGA	0.378													23	35					0	0	0	0	A	42585737	A	A	42585737	3	1	276	1	0	0	0	0	1	0	0	0	3407	1188	41	2	264	2	CHRNB3	8	42585737	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	351218	42585737	103778285	852	50741											
SNAI2	6591	broad.mit.edu	37	chr8	49832560	49832560	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtccgaatatgcatcttcaGggcgcccaggctcacatatt	9	10	10	12	2	3	0	2	0	1	0	4	1	4	0	2	3	1	2	2	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:49832560G>A	uc003xqp.2	-	2	684	c.520C>T	c.(520-522)CTG>TTG	p.L174L		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	174	C2H2-type 2.				canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				TGCATCTTCAGGGCGCCCAGG	0.488													14	77					0	0	0	0	A	49832560	A	A	49832560	2	1	276	1	0	0	0	0	0	0	0	1	14891	991	35	4		4	SNAI2	8	49832560	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7246823	49832560	96531462	853	50742											
SDCBP	6386	broad.mit.edu	37	chr8	59492285	59492285	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtgaaagatagctctgcaGccagaaatggtcttctcacg	12	10	10	9	1	3	3	1	1	3	2	4	3	3	3	1	1	3	2	1	1	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:59492285G>T	uc003xtn.2	+	7	832	c.682G>T	c.(682-684)GCC>TCC	p.A228S	SDCBP_uc003xto.2_Missense_Mutation_p.A227S|SDCBP_uc003xtr.2_Missense_Mutation_p.A227S|SDCBP_uc003xtp.2_Missense_Mutation_p.A222S|SDCBP_uc003xtq.2_Missense_Mutation_p.A228S|SDCBP_uc003xts.2_Missense_Mutation_p.A234S|SDCBP_uc011led.1_Missense_Mutation_p.A169S	NM_005625	NP_005616	O00560	SDCB1_HUMAN	syntenin isoform 1	228	PDZ 2.				actin cytoskeleton organization|axon guidance|positive regulation of phosphorylation|protein targeting to membrane|substrate-dependent cell migration, cell extension|synaptic transmission	cytoskeleton|cytosol|endoplasmic reticulum membrane|focal adhesion|interleukin-5 receptor complex|melanosome|nucleus	cytoskeletal adaptor activity|frizzled binding|interleukin-5 receptor binding|protein heterodimerization activity|protein N-terminus binding|syndecan binding				0		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TAGCTCTGCAGCCAGAAATGG	0.393													49	76					8.00217e-19	8.29661e-19	1	0	T	59492285	T	T	59492285	3	4	276	1	0	0	0	0	1	0	0	0	14020	971	34	4	704	4	SDCBP	8	59492285	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	9659725	59492285	86871737	854	50743											
CA8	767	broad.mit.edu	37	chr8	61121414	61121414	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaaagttgtctcccaaaatcCcatcacagccttccacaagt	13	9	5	14	0	2	0	1	0	1	0	5	1	4	0	4	0	1	1	4	0	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:61121414C>T	uc003xtz.1	-	8	1051	c.803G>A	c.(802-804)GGG>GAG	p.G268E	CA8_uc003xua.1_Missense_Mutation_p.G268E	NM_004056	NP_004047	P35219	CAH8_HUMAN	carbonic anhydrase VIII	268					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				TCCCAAAATCCCATCACAGCC	0.428													28	53					0	0	0	0	T	61121414	T	T	61121414	3	4	276	1	0	0	0	0	1	0	0	0	2535	623	22	4	73	4	CA8	8	61121414	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1629129	61121414	85242608	855	50744											
ASPH	444	broad.mit.edu	37	chr8	62475388	62475388	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttttaaggaagtatcattgGgaaatagttgaactaatctc	14	15	8	4	0	2	1	1	1	1	0	3	3	2	3	0	2	1	2	0	2	7	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:62475388G>A	uc003xuj.2	-	18	1621	c.1352C>T	c.(1351-1353)CCC>CTC	p.P451L	ASPH_uc011leg.1_Missense_Mutation_p.P422L|ASPH_uc003xuo.2_Missense_Mutation_p.P432L	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	451	Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	AGTATCATTGGGAAATAGTTG	0.353													26	111					0	0	0	0	A	62475388	A	A	62475388	3	1	276	1	0	0	0	0	1	0	0	0	1055	1232	43	4	956	4	ASPH	8	62475388	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1353974	62475388	83888634	856	50745											
CYP7B1	9420	broad.mit.edu	37	chr8	65528305	65528305	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggacatcttgcctgctttGaaaaacttctgaccatcctt	10	13	6	12	0	2	2	0	2	2	0	3	3	3	3	3	1	3	1	3	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:65528305G>A	uc003xvj.2	-	3	997	c.793C>T	c.(793-795)CAA>TAA	p.Q265*		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	265					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				TGCCTGCTTTGAAAAACTTCT	0.363													47	216					0	0	0	0	A	65528305	A	A	65528305	4	1	276	1	0	0	0	0	0	1	0	0	4214	1299	45	2	743	2	CYP7B1	8	65528305	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3052917	65528305	80835717	857	50746											
TRIM55	84675	broad.mit.edu	37	chr8	67040642	67040642	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtggttttggatagacatgGggtatatggacttcagagga	11	12	15	3	0	1	2	1	0	0	2	1	5	1	5	0	6	0	2	0	6	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:67040642G>A	uc003xvv.2	+	2	498	c.272G>A	c.(271-273)GGG>GAG	p.G91E	TRIM55_uc003xvu.2_Missense_Mutation_p.G91E|TRIM55_uc003xvw.2_Missense_Mutation_p.G91E|TRIM55_uc003xvx.2_Missense_Mutation_p.G91E	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	91						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GATAGACATGGGGTATATGGA	0.498													26	150					0	0	0	0	A	67040642	A	A	67040642	3	1	276	1	0	0	0	0	1	0	0	0	16596	1232	43	4	278	4	TRIM55	8	67040642	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1512337	67040642	79323380	858	50747											
PREX2	80243	broad.mit.edu	37	chr8	69031678	69031678	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gacatctaggtgatgaacttCccttaagtgttcgcatatct	10	14	8	9	1	2	2	0	2	2	0	4	3	3	2	1	1	1	2	1	1	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:69031678C>T	uc003xxv.1	+	28	3460	c.3433C>T	c.(3433-3435)CCC>TCC	p.P1145S		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1145					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TGATGAACTTCCCTTAAGTGT	0.318													17	80					0	0	0	0	T	69031678	T	T	69031678	3	4	276	1	0	0	0	0	1	0	0	0	12539	855	30	2	3772	2	PREX2	8	69031678	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1991036	69031678	77332344	859	50748											
C8orf34	116328	broad.mit.edu	37	chr8	69633671	69633671	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatctaaactaacaggacCtgtaagtatattcattgact	15	12	6	8	0	2	1	1	1	1	0	2	2	2	2	1	1	3	3	1	1	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:69633671C>T	uc010lyz.2	+	10	1194	c.1145C>T	c.(1144-1146)CCT>CTT	p.P382L	C8orf34_uc003xyb.2_Missense_Mutation_p.P357L	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	382					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CTAACAGGACCTGTAAGTATA	0.279													5	35					0	0	0	0	T	69633671	T	T	69633671	3	4	276	1	0	0	0	0	1	0	0	0	2434	695	24	4	1104	4	C8orf34	8	69633671	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	601993	69633671	76730351	860	50749											
PRDM14	63978	broad.mit.edu	37	chr8	70970904	70970904	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccggtgcttctcatgaacatGaagaatgtggatccgaagcc	11	9	11	10	2	1	3	1	2	1	1	3	5	2	4	3	2	3	1	3	2	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:70970904G>A	uc003xym.2	-	6	1559	c.1357C>T	c.(1357-1359)CAT>TAT	p.H453Y		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	453	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TCATGAACATGAAGAATGTGG	0.532													19	46					0	0	0	0	A	70970904	A	A	70970904	3	1	276	1	0	0	0	0	1	0	0	0	12517	1290	45	2	370	2	PRDM14	8	70970904	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1337233	70970904	75393118	861	50750											
STAU2	27067	broad.mit.edu	37	chr8	74529566	74529566	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataggttcattctgcagtgcTtggagggctttcattgcagc	7	14	12	8	0	3	0	2	0	1	0	3	1	3	1	0	3	4	5	0	3	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:74529566T>A	uc003xzm.2	-	7	767	c.531A>T	c.(529-531)CAA>CAT	p.Q177H	STAU2_uc011lfg.1_Missense_Mutation_p.Q5H|STAU2_uc003xzn.2_Missense_Mutation_p.Q145H|STAU2_uc011lfh.1_Missense_Mutation_p.Q73H|STAU2_uc003xzo.2_Missense_Mutation_p.Q177H|STAU2_uc003xzp.2_Missense_Mutation_p.Q145H|STAU2_uc011lfi.1_Missense_Mutation_p.Q139H|STAU2_uc003xzq.2_Translation_Start_Site|STAU2_uc010lzk.2_Missense_Mutation_p.Q145H|STAU2_uc010lzl.1_Missense_Mutation_p.Q5H	NM_014393	NP_055208	Q9NUL3	STAU2_HUMAN	staufen homolog 2 isoform e	177	DRBM 2.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding				0	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			TCTGCAGTGCTTGGAGGGCTT	0.433													24	46					0	0	0	0	A	74529566	A	A	74529566	3	1	276	1	0	0	0	0	1	0	0	0	15339	1606	56	5	1341	5	STAU2	8	74529566	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	3558662	74529566	71834456	862	50751											
ZFHX4	79776	broad.mit.edu	37	chr8	77764288	77764288	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcaagccgcattctttcagCctcagtttctaaacccagcc	10	10	6	15	1	4	0	2	0	2	0	4	0	4	0	4	0	5	3	4	0	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:77764288C>T	uc003yav.2	+	10	5383	c.4996C>T	c.(4996-4998)CCT>TCT	p.P1666S	ZFHX4_uc003yau.1_Missense_Mutation_p.P1711S|ZFHX4_uc003yaw.1_Missense_Mutation_p.P1666S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1666	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATTCTTTCAGCCTCAGTTTCT	0.453										HNSCC(33;0.089)			16	73					0	0	0	0	T	77764288	T	T	77764288	3	4	276	1	0	0	0	0	1	0	0	0	17702	739	26	4	5165	4	ZFHX4	8	77764288	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3234722	77764288	68599734	863	50752											
ZFHX4	79776	broad.mit.edu	37	chr8	77766126	77766126	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcaatgtggttttccccagGatctttgacttgattacgca	8	15	9	9	1	1	2	0	2	1	0	2	3	2	3	2	2	2	3	2	2	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:77766126G>A	uc003yav.2	+	10	7221	c.6834G>A	c.(6832-6834)AGG>AGA	p.R2278R	ZFHX4_uc003yau.1_Silent_p.R2323R|ZFHX4_uc003yaw.1_Silent_p.R2278R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2278	C2H2-type 15; degenerate.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTTTCCCCAGGATCTTTGACT	0.398										HNSCC(33;0.089)			29	72					0	0	0	0	A	77766126	A	A	77766126	2	1	276	1	0	0	0	0	0	0	0	1	17702	1165	41	2		2	ZFHX4	8	77766126	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1838	77766126	68597896	864	50753											
ZNF704	619279	broad.mit.edu	37	chr8	81733814	81733814	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgttttaagtcctctgactGaaatgtgaaggtcatttccc	10	14	8	9	1	2	3	1	3	1	0	4	3	4	3	2	1	0	1	2	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:81733814G>A	uc003yby.1	-	2	248	c.16C>T	c.(16-18)CAG>TAG	p.Q6*		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	6						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			TCCTCTGACTGAAATGTGAAG	0.408													63	145					0	0	0	0	A	81733814	A	A	81733814	4	1	276	1	0	0	0	0	0	1	0	0	18174	1299	45	2	1254	2	ZNF704	8	81733814	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3967688	81733814	64630208	865	50754											
E2F5	1875	broad.mit.edu	37	chr8	86114445	86114445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atatcaccaatgtcttagagGgaattgacttgattgaaaaa	16	12	8	5	0	2	4	1	3	1	1	2	5	2	5	1	1	0	0	1	1	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:86114445G>A	uc003ycz.3	+	2	335	c.298G>A	c.(298-300)GGA>AGA	p.G100R	E2F5_uc003yda.3_Missense_Mutation_p.G100R|E2F5_uc010mab.2_5'UTR	NM_001951	NP_001942	Q15329	E2F5_HUMAN	E2F transcription factor 5 isoform 1	100	Potential.|DEF box.				G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1						TGTCTTAGAGGGAATTGACTT	0.388													4	42					0	0	0	0	A	86114445	A	A	86114445	3	1	276	1	0	0	0	0	1	0	0	0	4892	1233	43	4	304	4	E2F5	8	86114445	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4380631	86114445	60249577	866	50755											
DCAF4L2	138009	broad.mit.edu	37	chr8	88885084	88885084	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgctcctcggaagcccccGaggcgagaagagaaggccac	10	3	15	13	3	0	2	0	0	0	2	2	6	1	3	4	4	2	1	4	4	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:88885084G>A	uc003ydz.2	-	1	1213	c.1116C>T	c.(1114-1116)CTC>CTT	p.L372L		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	372										ovary(1)	1						GGAAGCCCCCGAGGCGAGAAG	0.592													23	51					0	0	0	0	A	88885084	A	A	88885084	2	1	276	1	0	0	0	0	0	0	0	1	4289	1045	37	1		1	DCAF4L2	8	88885084	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2770639	88885084	57478938	867	50756											
MMP16	4325	broad.mit.edu	37	chr8	89179964	89179964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgggtatctcctccaattcCtggtccagggaagtaggcat	9	11	11	10	0	1	0	0	0	1	0	5	1	4	1	4	4	0	3	4	4	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:89179964C>T	uc003yeb.3	-	4	925	c.643G>A	c.(643-645)GGA>AGA	p.G215R	MMP16_uc003yec.2_Missense_Mutation_p.G215R	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	215	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						CCTCCAATTCCTGGTCCAGGG	0.418													10	46					0	0	0	0	T	89179964	T	T	89179964	3	4	276	1	0	0	0	0	1	0	0	0	9708	690	24	4	1364	4	MMP16	8	89179964	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	294880	89179964	57184058	868	50757											
GEM	2669	broad.mit.edu	37	chr8	95262787	95262787	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggtctcgatgaacttgcaGtcaaacaccactgcacaggc	12	7	10	12	1	2	1	1	1	1	0	3	3	2	1	1	2	4	2	1	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:95262787G>A	uc003ygj.2	-	5	891	c.642C>T	c.(640-642)GAC>GAT	p.D214D	GEM_uc003ygi.2_Silent_p.D214D	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein	214					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			TGAACTTGCAGTCAAACACCA	0.562													12	24					0	0	0	0	A	95262787	A	A	95262787	2	1	276	1	0	0	0	0	0	0	0	1	6366	1020	36	4		4	GEM	8	95262787	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6082823	95262787	51101235	869	50758											
ESRP1	54845	broad.mit.edu	37	chr8	95653671	95653671	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaagtcgtggatctggccaAcaagaaggtatttctccaca	13	9	10	9	1	2	1	0	0	2	1	4	3	2	2	2	3	1	1	2	3	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:95653671A>G	uc003ygq.3	+	1	308	c.125A>G	c.(124-126)AAC>AGC	p.N42S	ESRP1_uc003ygr.3_Missense_Mutation_p.N42S|ESRP1_uc003ygs.3_Missense_Mutation_p.N42S|ESRP1_uc003ygt.3_Missense_Mutation_p.N42S|ESRP1_uc003ygu.3_Missense_Mutation_p.N42S	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	42					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						GATCTGGCCAACAAGAAGGTA	0.522													35	81					0	0	0	0	G	95653671	G	G	95653671	3	3	276	1	0	0	0	0	1	0	0	0	5282	43	2	5	127	5	ESRP1	8	95653671	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	390884	95653671	50710351	870	50759											
PGCP	10404	broad.mit.edu	37	chr8	98155359	98155359	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttgctgctgctgtttgggCtgttgtttcttatgttgttg	1	22	13	5	0	1	0	0	0	1	0	1	0	1	0	0	1	3	10	0	1	1	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:98155359C>T	uc003yhw.2	+	8	1533	c.1367C>T	c.(1366-1368)GCT>GTT	p.A456V		NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	456					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					GCTGTTTGGGCTGTTGTTTCT	0.443													9	89					0	0	0	0	T	98155359	T	T	98155359	3	4	276	1	0	0	0	0	1	0	0	0	11841	797	28	4	1393	4	PGCP	8	98155359	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2501688	98155359	48208663	871	50760											
TSPYL5	85453	broad.mit.edu	37	chr8	98289088	98289089	+	Nonsense_Mutation	DNP	GG	AA	AA																															atcatgccctgggagccactGgattggagtagaacgagaca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:98289088_98289089GG>AA	uc003yhy.2	-	1	1088_1089	c.984_985CC>TT	c.(982-987)ATCCAG>ATTTAG	p.Q329*		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	329					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					GGGAGCCACTGGATTGGAGTAG	0.495													14	78					0	0	0	0	AA	98289089	AA	AA	98289088	4	1	276	1	0	0	0	0	0	1	0	0	16729	1357	47	4	272	4	TSPYL5	8	98289088	Nonsense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	133729	98289088	48074934	872	50761											
SPAG1	6674	broad.mit.edu	37	chr8	101174571	101174571	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaaaacattcaaaattccCattgaacatctagatttcaa	19	11	2	9	0	3	2	2	1	1	1	4	2	4	2	1	0	2	0	1	0	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:101174571C>T	uc003yjh.1	+	2	149	c.63C>T	c.(61-63)CCC>CCT	p.P21P	SPAG1_uc003yjg.1_Silent_p.P21P|SPAG1_uc003yji.1_Silent_p.P21P	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	21					single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		TCAAAATTCCCATTGAACATC	0.294													5	22					0	0	0	0	T	101174571	T	T	101174571	2	4	276	1	0	0	0	0	0	0	0	1	15041	581	21	4		4	SPAG1	8	101174571	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2885483	101174571	45189451	873	50762											
GRHL2	79977	broad.mit.edu	37	chr8	102570885	102570885	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggccccacctgtgcactatCcccggggagatggggaagag	8	6	15	12	1	0	2	0	0	0	2	1	4	1	3	5	5	1	1	5	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:102570885C>T	uc010mbu.2	+	4	853	c.523C>T	c.(523-525)CCC>TCC	p.P175S	GRHL2_uc011lhi.1_Missense_Mutation_p.P175S	NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	175						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TGTGCACTATCCCCGGGGAGA	0.562													28	54					0	0	0	0	T	102570885	T	T	102570885	3	4	276	1	0	0	0	0	1	0	0	0	6803	855	30	2	537	2	GRHL2	8	102570885	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1396314	102570885	43793137	874	50763											
UBR5	51366	broad.mit.edu	37	chr8	103310705	103310705	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctgacataaatggggtcatCcctcttgcatccctaaaata	12	11	7	11	0	2	1	1	1	1	0	4	1	4	1	2	2	1	2	2	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:103310705C>T	uc003ykr.1	-	26	3372	c.3339G>A	c.(3337-3339)GGG>GGA	p.G1113G	UBR5_uc003yks.1_Silent_p.G1113G	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1113					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			ATGGGGTCATCCCTCTTGCAT	0.299													13	37					0	0	0	0	T	103310705	T	T	103310705	2	4	276	1	0	0	0	0	0	0	0	1	16973	842	30	2		2	UBR5	8	103310705	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	739820	103310705	43053317	875	50764											
RIMS2	9699	broad.mit.edu	37	chr8	104940078	104940078	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttgcttaccagagccaaagCcttagtagaagaacaacgcc	14	8	8	11	1	0	3	0	0	0	3	0	3	0	3	4	0	6	2	4	0	7	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:104940078C>T	uc003yls.2	+	9	1780	c.1539C>T	c.(1537-1539)AGC>AGT	p.S513S	RIMS2_uc003ylp.2_Silent_p.S735S|RIMS2_uc003ylw.2_Intron|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron|RIMS2_uc003ylt.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGAGCCAAAGCCTTAGTAGAA	0.229										HNSCC(12;0.0054)			8	21					0	0	0	0	T	104940078	T	T	104940078	2	4	276	1	0	0	0	0	0	0	0	1	13433	738	26	4		4	RIMS2	8	104940078	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1629373	104940078	41423944	876	50765											
ABRA	137735	broad.mit.edu	37	chr8	107782215	107782215	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctttctggtgtgaagtaggGggtgtgattggtttaggagc	6	14	18	3	0	1	2	0	2	1	0	1	3	1	3	0	5	1	3	0	5	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:107782215G>A	uc003ymm.3	-	1	258	c.204C>T	c.(202-204)CCC>CCT	p.P68P		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	68					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			GTGAAGTAGGGGGTGTGATTG	0.587													39	72					0	0	0	0	A	107782215	A	A	107782215	2	1	276	1	0	0	0	0	0	0	0	1	100	1219	43	4		4	ABRA	8	107782215	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2842137	107782215	38581807	877	50766											
TRHR	7201	broad.mit.edu	37	chr8	110131279	110131279	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctctatttctccctaggtCaccaagatgctggcagtggt	7	13	9	12	0	3	1	1	0	2	1	5	1	3	1	2	3	1	2	2	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:110131279C>T	uc003ymz.3	+	2	808	c.792C>T	c.(790-792)GTC>GTT	p.V264V		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	264	Cytoplasmic (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CTCCCTAGGTCACCAAGATGC	0.393													100	220					0	0	0	0	T	110131279	T	T	110131279	2	4	276	1	0	0	0	0	0	0	0	1	16547	813	29	2		2	TRHR	8	110131279	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2349064	110131279	36232743	878	50767											
PKHD1L1	93035	broad.mit.edu	37	chr8	110416808	110416808	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atattgaaatcttgctgcagGagtacagattaagtgcattt	13	14	9	5	0	1	2	0	1	1	1	1	3	1	3	0	1	4	4	0	1	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:110416808G>A	uc003yne.2	+	15	1503	c.1399G>A	c.(1399-1401)GAG>AAG	p.E467K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	467	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTTGCTGCAGGAGTACAGATT	0.308										HNSCC(38;0.096)			10	25					0	0	0	0	A	110416808	A	A	110416808	3	1	276	1	0	0	0	0	1	0	0	0	12027	1175	41	2	1457	2	PKHD1L1	8	110416808	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	285529	110416808	35947214	879	50768											
PKHD1L1	93035	broad.mit.edu	37	chr8	110520013	110520013	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatacctcaagcagaatatGaatgggacggaaacagccaa	17	6	10	8	1	1	3	1	2	0	1	1	5	1	5	2	2	4	1	2	2	7	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:110520013G>A	uc003yne.2	+	69	11220	c.11116G>A	c.(11116-11118)GAA>AAA	p.E3706K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3706	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGCAGAATATGAATGGGACGG	0.433										HNSCC(38;0.096)			20	117					0	0	0	0	A	110520013	A	A	110520013	3	1	276	1	0	0	0	0	1	0	0	0	12027	1291	45	2	11390	2	PKHD1L1	8	110520013	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	103205	110520013	35844009	880	50769											
CSMD3	114788	broad.mit.edu	37	chr8	113299443	113299443	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctagagccatggccgggagTacctggatcgccacatgtcc	8	8	12	13	2	1	1	0	0	1	1	3	3	2	3	5	3	2	1	5	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:113299443T>C	uc003ynu.2	-	58	9340	c.9181A>G	c.(9181-9183)ACT>GCT	p.T3061A	CSMD3_uc003yns.2_Missense_Mutation_p.T2263A|CSMD3_uc003ynt.2_Missense_Mutation_p.T3021A|CSMD3_uc011lhx.1_Missense_Mutation_p.T2892A	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3061	Extracellular (Potential).|Sushi 22.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGGCCGGGAGTACCTGGATCG	0.423										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	90					0	0	0	0	C	113299443	C	C	113299443	3	2	276	1	0	0	0	0	1	0	0	0	3963	1638	57	5	1998	5	CSMD3	8	113299443	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	2779430	113299443	33064579	881	50770											
CSMD3	114788	broad.mit.edu	37	chr8	113697955	113697955	+	Missense_Mutation	SNP	C	A	A																															gtgcagtaaagttagacaggCagggaactggtgaaacagga																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:113697955C>A	uc003ynu.2	-	15	2321	c.2162G>T	c.(2161-2163)TGC>TTC	p.C721F	CSMD3_uc003yns.2_5'UTR|CSMD3_uc003ynt.2_Missense_Mutation_p.C681F|CSMD3_uc011lhx.1_Missense_Mutation_p.C617F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	721	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTTAGACAGGCAGGGAACTGG	0.313										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			18	81					1.02788e-11	1.0545e-11	1	0	A	113697955	A	A	113697955	3	1	276	1	0	0	0	0	1	0	0	0	3963	710	25	4	9189	4	CSMD3	8	113697955	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	398512	113697955	32666067	882	50771	114	2									
CSMD3	114788	broad.mit.edu	37	chr8	113697958	113697958	+	Missense_Mutation	SNP	G	A	A																															cagtaaagttagacaggcagGgaactggtgaaacaggaaga																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:113697958G>A	uc003ynu.2	-	15	2318	c.2159C>T	c.(2158-2160)CCC>CTC	p.P720L	CSMD3_uc003yns.2_5'UTR|CSMD3_uc003ynt.2_Missense_Mutation_p.P680L|CSMD3_uc011lhx.1_Missense_Mutation_p.P616L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	720	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGACAGGCAGGGAACTGGTGA	0.318										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	78					0	0	0	0	A	113697958	A	A	113697958	3	1	276	1	0	0	0	0	1	0	0	0	3963	1232	43	4	9192	4	CSMD3	8	113697958	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3	113697958	32666064	883	50772	114	2									
CSMD3	114788	broad.mit.edu	37	chr8	114326862	114326862	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gataagtagtcgtattcttcTtctagagcaaatgactgaaa	14	13	8	6	1	3	3	0	2	3	1	4	4	3	3	0	0	1	3	0	0	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:114326862T>C	uc003ynu.2	-	2	498	c.339A>G	c.(337-339)GAA>GAG	p.E113E	CSMD3_uc003ynt.2_Silent_p.E73E|CSMD3_uc011lhx.1_Silent_p.E113E|CSMD3_uc010mcx.1_Silent_p.E113E|CSMD3_uc003ynx.3_Silent_p.E113E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	113	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CGTATTCTTCTTCTAGAGCAA	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			44	91					0	0	0	0	C	114326862	C	C	114326862	2	2	276	1	0	0	0	0	0	0	0	1	3963	1606	56	5		5	CSMD3	8	114326862	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	628904	114326862	32037160	884	50773											
MED30	90390	broad.mit.edu	37	chr8	118542972	118542972	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcattcccagcaacttattcCatatgtggaagaagatggct	12	12	8	9	0	1	2	1	0	0	2	3	3	3	3	2	2	2	2	2	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:118542972C>T	uc003yoj.2	+	3	498	c.347C>T	c.(346-348)CCA>CTA	p.P116L	MED30_uc011lib.1_Intron	NM_080651	NP_542382	Q96HR3	MED30_HUMAN	TRAP/Mediator complex component TRAP25	116					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding				0	all_cancers(13;3.41e-25)|Lung NSC(37;3.02e-05)|Ovarian(258;0.00163)		STAD - Stomach adenocarcinoma(47;0.0266)			CAACTTATTCCATATGTGGAA	0.348													15	35					0	0	0	0	T	118542972	T	T	118542972	3	4	276	1	0	0	0	0	1	0	0	0	9501	594	21	4	357	4	MED30	8	118542972	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4216110	118542972	27821050	885	50774											
TNFRSF11B	4982	broad.mit.edu	37	chr8	119945375	119945375	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tctgtgtagtagtggtcaggGcaaggggcgcacacggtctt	7	10	16	8	2	3	0	1	0	2	0	3	0	3	0	0	5	0	4	0	5	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:119945375G>A	uc003yon.3	-	2	518	c.195C>T	c.(193-195)TGC>TGT	p.C65C	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	65	TNFR-Cys 2.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			AGTGGTCAGGGCAAGGGGCGC	0.527													84	174					0	0	0	0	A	119945375	A	A	119945375	2	1	276	1	0	0	0	0	0	0	0	1	16351	1195	42	4		4	TNFRSF11B	8	119945375	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1402403	119945375	26418647	886	50775											
MAL2	114569	broad.mit.edu	37	chr8	120252438	120252438	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attttacagtatttgtcttcTattttggagcctttttattg	7	23	6	5	0	2	0	0	0	2	0	2	1	2	1	1	1	2	1	1	1	4	12			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:120252438T>C	uc003yop.2	+	4	439	c.337T>C	c.(337-339)TAT>CAT	p.Y113H		NM_052886	NP_443118	Q969L2	MAL2_HUMAN	MAL2 proteolipid protein	113	MARVEL.|Helical; (Potential).					apical plasma membrane|endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding				0	all_cancers(13;1.91e-26)|Lung NSC(37;8.61e-08)|Ovarian(258;0.018)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000967)			ATTTGTCTTCTATTTTGGAGC	0.358													39	79					0	0	0	0	C	120252438	C	C	120252438	3	2	276	1	0	0	0	0	1	0	0	0	9253	1522	53	5	348	5	MAL2	8	120252438	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	307063	120252438	26111584	887	50776											
COL14A1	7373	broad.mit.edu	37	chr8	121381580	121381580	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acttcttaggaccttcagggGagagtcggcctggcagccct	7	9	13	12	1	2	1	1	0	1	1	3	3	2	2	3	5	1	1	3	5	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:121381580G>A	uc003yox.2	+	47	5432	c.5167G>A	c.(5167-5169)GAG>AAG	p.E1723K	COL14A1_uc003yoz.2_Missense_Mutation_p.E688K	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1723	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACCTTCAGGGGAGAGTCGGCC	0.562													10	88					0	0	0	0	A	121381580	A	A	121381580	3	1	276	1	0	0	0	0	1	0	0	0	3686	1175	41	2	5349	2	COL14A1	8	121381580	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1129142	121381580	24982442	888	50777											
HAS2	3037	broad.mit.edu	37	chr8	122626849	122626849	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtggcaatgagaaagaaagGaaagaatccagtgataatcg	18	7	12	4	1	0	4	0	2	0	3	2	6	1	5	1	2	0	1	1	2	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:122626849G>A	uc003yph.2	-	4	1697	c.1159C>T	c.(1159-1161)CCT>TCT	p.P387S		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	387	Helical; Name=3; (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			AGAAAGAAAGGAAAGAATCCA	0.423													12	105					0	0	0	0	A	122626849	A	A	122626849	3	1	276	1	0	0	0	0	1	0	0	0	7001	1174	41	2	503	2	HAS2	8	122626849	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1245269	122626849	23737173	889	50778											
SQLE	6713	broad.mit.edu	37	chr8	126011730	126011730	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttggccaacagggaggtcCtgttgtgcgtgctggtgttc	4	13	15	9	1	0	0	0	0	0	0	2	1	1	1	2	4	3	3	2	4	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:126011730C>T	uc011liq.1	+	1	1011	c.85C>T	c.(85-87)CTG>TTG	p.L29L		NM_003129	NP_003120	Q14534	ERG1_HUMAN	squalene epoxidase	29	Helical; (Potential).				cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			ovary(1)|breast(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	CAGGGAGGTCCTGTTGTGCGT	0.572													10	29					0	0	0	0	T	126011730	T	T	126011730	2	4	276	1	0	0	0	0	0	0	0	1	15194	680	24	4		4	SQLE	8	126011730	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3384881	126011730	20352292	890	50779											
ADCY8	114	broad.mit.edu	37	chr8	131792678	131792678	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgccttcagcctgggctccAggctctgtgccgctgggtga	3	10	15	13	1	2	1	1	1	1	0	3	1	3	1	4	3	3	3	4	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:131792678A>G	uc003ytd.3	-	18	3970	c.3714T>C	c.(3712-3714)CCT>CCC	p.P1238P	ADCY8_uc010mds.2_Silent_p.P1107P	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1238	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CCTGGGCTCCAGGCTCTGTGC	0.393										HNSCC(32;0.087)			42	62					0	0	0	0	G	131792678	G	G	131792678	2	3	276	1	0	0	0	0	0	0	0	1	300	175	7	5		5	ADCY8	8	131792678	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	5780948	131792678	14571344	891	50780											
ADCY8	114	broad.mit.edu	37	chr8	131797639	131797639	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtcctttacctgtttttcaGgtgacaggcctgacacggcc	7	12	10	12	1	1	2	1	2	0	0	2	2	2	2	4	3	1	1	4	3	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:131797639G>A	uc003ytd.3	-	16	3399	c.3143C>T	c.(3142-3144)CCT>CTT	p.P1048L	ADCY8_uc010mds.2_Missense_Mutation_p.P917L	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1048	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTGTTTTTCAGGTGACAGGCC	0.498										HNSCC(32;0.087)			13	80					0	0	0	0	A	131797639	A	A	131797639	3	1	276	1	0	0	0	0	1	0	0	0	300	1000	35	4	624	4	ADCY8	8	131797639	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4961	131797639	14566383	892	50781											
EFR3A	23167	broad.mit.edu	37	chr8	132982751	132982751	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgctggaagtcttcaatacCcttttgaaacatctgcgtct	9	14	8	10	1	4	1	1	1	3	0	4	2	4	2	1	1	4	1	1	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:132982751C>T	uc003yte.2	+	10	1221	c.1020C>T	c.(1018-1020)ACC>ACT	p.T340T		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	340						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TCTTCAATACCCTTTTGAAAC	0.383													18	33					0	0	0	0	T	132982751	T	T	132982751	2	4	276	1	0	0	0	0	0	0	0	1	4980	610	22	4		4	EFR3A	8	132982751	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1185112	132982751	13381271	893	50782											
EFR3A	23167	broad.mit.edu	37	chr8	132999915	132999915	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaagtggatatagtgttgaGagattgtcagttccgtatgt	10	14	14	3	1	1	2	1	1	0	1	2	5	2	4	1	2	0	3	1	2	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:132999915G>A	uc003yte.2	+	18	2232	c.2031G>A	c.(2029-2031)GAG>GAA	p.E677E		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	677						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			ATAGTGTTGAGAGATTGTCAG	0.373													5	12					0	0	0	0	A	132999915	A	A	132999915	2	1	276	1	0	0	0	0	0	0	0	1	4980	933	33	2		2	EFR3A	8	132999915	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	17164	132999915	13364107	894	50783											
TG	7038	broad.mit.edu	37	chr8	133899039	133899039	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagcaaaacctttttggaggGaaatttttggtgaatgttgg	11	14	12	4	0	0	1	0	1	0	0	0	3	0	3	1	4	2	2	1	4	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:133899039G>A	uc003ytw.2	+	9	1463	c.1422G>A	c.(1420-1422)GGG>GGA	p.G474G		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	474					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TTTTTGGAGGGAAATTTTTGG	0.468													17	108					0	0	0	0	A	133899039	A	A	133899039	2	1	276	1	0	0	0	0	0	0	0	1	15879	1161	41	2		2	TG	8	133899039	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	899124	133899039	12464983	895	50784											
TG	7038	broad.mit.edu	37	chr8	133984060	133984060	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttctttgaatgtgaacgacgGtgcgatgcggacccatgctg	8	11	13	9	4	1	2	0	2	1	0	1	5	1	3	1	2	4	1	1	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:133984060G>A	uc003ytw.2	+	33	6038	c.5997G>A	c.(5995-5997)CGG>CGA	p.R1999R	TG_uc010mdw.2_Silent_p.R758R|TG_uc011ljb.1_Silent_p.R368R|TG_uc011ljc.1_Silent_p.R153R	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1999	Type IIIB.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTGAACGACGGTGCGATGCGG	0.403													22	35					0	0	0	0	A	133984060	A	A	133984060	2	1	276	1	0	0	0	0	0	0	0	1	15879	1248	44	4		4	TG	8	133984060	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	85021	133984060	12379962	896	50785											
TG	7038	broad.mit.edu	37	chr8	134144090	134144090	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cggatgttcagtttgccttgGggcttcccttctacccagcc	4	13	10	14	1	2	0	1	0	1	0	3	1	3	1	4	3	3	3	4	3	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:134144090G>A	uc003ytw.2	+	46	7938	c.7897G>A	c.(7897-7899)GGG>AGG	p.G2633R	TG_uc010mdw.2_Missense_Mutation_p.G1392R|TG_uc011ljb.1_Missense_Mutation_p.G1002R|TG_uc011ljc.1_Missense_Mutation_p.G766R	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2633					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTTTGCCTTGGGGCTTCCCTT	0.488													33	61					0	0	0	0	A	134144090	A	A	134144090	3	1	276	1	0	0	0	0	1	0	0	0	15879	1232	43	4	8079	4	TG	8	134144090	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	160030	134144090	12219932	897	50786											
TG	7038	broad.mit.edu	37	chr8	134147017	134147017	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaagcctccaggaaccaggCtctaagacctacagcaagtg	13	6	9	13	0	1	1	0	0	1	1	2	2	2	2	4	2	4	2	4	2	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:134147017C>T	uc003ytw.2	+	48	8327	c.8286C>T	c.(8284-8286)GGC>GGT	p.G2762G	TG_uc010mdw.2_Silent_p.G1521G|TG_uc011ljb.1_Silent_p.G1131G|TG_uc011ljc.1_Silent_p.G895G	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2762					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGGAACCAGGCTCTAAGACCT	0.537													18	24					0	0	0	0	T	134147017	T	T	134147017	2	4	276	1	0	0	0	0	0	0	0	1	15879	784	28	4		4	TG	8	134147017	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2927	134147017	12217005	898	50787											
FAM135B	51059	broad.mit.edu	37	chr8	139158208	139158208	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtatcatcatacctgattCttttcagacattaggaagtc	11	16	6	8	0	4	2	3	1	1	1	5	3	4	3	1	1	1	1	1	1	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:139158208C>T	uc003yuy.2	-	15	3705	c.3534G>A	c.(3532-3534)AAG>AAA	p.K1178K	FAM135B_uc003yux.2_Silent_p.K1079K|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.K740K|FAM135B_uc003yvb.2_3'UTR	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1178										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATACCTGATTCTTTTCAGACA	0.428										HNSCC(54;0.14)			16	130					0	0	0	0	T	139158208	T	T	139158208	2	4	276	1	0	0	0	0	0	0	0	1	5477	912	32	2		2	FAM135B	8	139158208	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5011191	139158208	7205814	899	50788											
FAM135B	51059	broad.mit.edu	37	chr8	139164563	139164563	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccggtggagggcatgtcttcGaacaaacgggtgcaagactt	10	8	14	9	3	1	1	0	0	1	1	2	3	1	2	1	4	3	2	1	4	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:139164563G>A	uc003yuy.2	-	13	2326	c.2155C>T	c.(2155-2157)CGA>TGA	p.R719*	FAM135B_uc003yux.2_Nonsense_Mutation_p.R620*|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Nonsense_Mutation_p.R281*|FAM135B_uc003yvb.2_Nonsense_Mutation_p.R281*	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	719										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCATGTCTTCGAACAAACGGG	0.567										HNSCC(54;0.14)			8	44					0	0	0	0	A	139164563	A	A	139164563	4	1	276	1	0	0	0	0	0	1	0	0	5477	1066	37	1	2097	1	FAM135B	8	139164563	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6355	139164563	7199459	900	50789											
FAM135B	51059	broad.mit.edu	37	chr8	139164907	139164907	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttgttttgtctgaagagatgGcattttggtggcttccacct	6	17	11	7	0	1	2	0	1	1	1	2	3	2	2	2	3	0	3	2	3	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:139164907G>A	uc003yuy.2	-	13	1982	c.1811C>T	c.(1810-1812)GCC>GTC	p.A604V	FAM135B_uc003yux.2_Missense_Mutation_p.A505V|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.A166V|FAM135B_uc003yvb.2_Missense_Mutation_p.A166V	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	604										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGAAGAGATGGCATTTTGGTG	0.458										HNSCC(54;0.14)			27	200					0	0	0	0	A	139164907	A	A	139164907	3	1	276	1	0	0	0	0	1	0	0	0	5477	1203	42	4	2441	4	FAM135B	8	139164907	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	344	139164907	7199115	901	50790											
FAM135B	51059	broad.mit.edu	37	chr8	139165102	139165102	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catcctctggacctggactcCttctagaagtatccacatct	9	12	6	14	0	3	1	0	0	3	1	6	3	6	3	4	2	0	1	4	2	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:139165102C>T	uc003yuy.2	-	13	1787	c.1616G>A	c.(1615-1617)AGG>AAG	p.R539K	FAM135B_uc003yux.2_Missense_Mutation_p.R440K|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.R101K|FAM135B_uc003yvb.2_Missense_Mutation_p.R101K	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	539										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACCTGGACTCCTTCTAGAAGT	0.498										HNSCC(54;0.14)			10	66					0	0	0	0	T	139165102	T	T	139165102	3	4	276	1	0	0	0	0	1	0	0	0	5477	681	24	4	2636	4	FAM135B	8	139165102	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	195	139165102	7198920	902	50791											
COL22A1	169044	broad.mit.edu	37	chr8	139890021	139890021	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agacggcgccgcagcttgccCcggatcttgtcgatggcatt	6	9	13	13	5	1	1	0	0	1	1	2	3	1	2	3	3	2	3	3	3	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:139890021C>T	uc003yvd.2	-	3	1077	c.630G>A	c.(628-630)CGG>CGA	p.R210R		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	210	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GCAGCTTGCCCCGGATCTTGT	0.662										HNSCC(7;0.00092)			21	45					0	0	0	0	T	139890021	T	T	139890021	2	4	276	1	0	0	0	0	0	0	0	1	3696	610	22	4		4	COL22A1	8	139890021	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	724919	139890021	6474001	903	50792											
FLJ43860	389690	broad.mit.edu	37	chr8	142500263	142500263	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tagaggaggcttctgtgtggGaagacgcccgtcaggagctc	8	8	16	9	2	2	2	1	0	1	2	3	5	2	5	1	4	1	2	1	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:142500263G>A	uc003ywi.2	-	5	732	c.651C>T	c.(649-651)TTC>TTT	p.F217F	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	217							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TTCTGTGTGGGAAGACGCCCG	0.642													6	29					0	0	0	0	A	142500263	A	A	142500263	2	1	276	1	0	0	0	0	0	0	0	1	5962	1165	41	2		2	FLJ43860	8	142500263	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2610242	142500263	3863759	904	50793											
FLJ43860	389690	broad.mit.edu	37	chr8	142506435	142506435	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtcacctgcactgtaggcttCccccatgaacatcctgtgct	7	11	8	15	0	1	1	1	1	0	0	3	1	3	1	4	1	3	4	4	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:142506435C>T	uc003ywi.2	-	2	328	c.247G>A	c.(247-249)GAA>AAA	p.E83K	FLJ43860_uc011ljs.1_5'Flank|FLJ43860_uc010meu.1_5'Flank	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	83							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CTGTAGGCTTCCCCCATGAAC	0.637													20	28					0	0	0	0	T	142506435	T	T	142506435	3	4	276	1	0	0	0	0	1	0	0	0	5962	864	30	2	3825	2	FLJ43860	8	142506435	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6172	142506435	3857587	905	50794											
FAM83H	286077	broad.mit.edu	37	chr8	144808904	144808904	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accggactacccctgcgctcGgggtaggctgaggtggggct	5	7	17	12	3	0	1	0	1	0	0	1	2	0	2	3	7	2	4	3	7	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:144808904G>A	uc003yzk.2	-	5	2796	c.2727C>T	c.(2725-2727)CCC>CCT	p.P909P	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	909					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCCTGCGCTCGGGGTAGGCTG	0.677													5	16					0	0	0	0	A	144808904	A	A	144808904	2	1	276	1	0	0	0	0	0	0	0	1	5672	1103	39	1		1	FAM83H	8	144808904	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2302469	144808904	1555118	906	50795											
EPPK1	83481	broad.mit.edu	37	chr8	144940361	144940361	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtccacgggcacgcggtggCtgtgcacggggtcgatgacg	5	6	18	12	7	0	1	0	1	0	0	2	2	1	1	1	5	1	3	1	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:144940361C>T	uc003zaa.1	-	2	15084	c.15071G>A	c.(15070-15072)AGC>AAC	p.S5024N		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5024	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CACGCGGTGGCTGTGCACGGG	0.687													20	472					0	0	0	0	T	144940361	T	T	144940361	3	4	276	1	0	0	0	0	1	0	0	0	5214	797	28	4	205	4	EPPK1	8	144940361	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	131457	144940361	1423661	907	50796											
EPPK1	83481	broad.mit.edu	37	chr8	144941347	144941347	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgtaggctgtttccagtggGagccggtggtggtgctgtgg	3	12	19	7	1	0	0	0	0	0	0	1	1	1	1	2	6	2	4	2	6	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:144941347G>A	uc003zaa.1	-	1	6088	c.6075C>T	c.(6073-6075)CTC>CTT	p.L2025L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2025	Plectin 34.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TTTCCAGTGGGAGCCGGTGGT	0.602													7	55					0	0	0	0	A	144941347	A	A	144941347	2	1	276	1	0	0	0	0	0	0	0	1	5214	1161	41	2		2	EPPK1	8	144941347	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	986	144941347	1422675	908	50797											
PLEC	5339	broad.mit.edu	37	chr8	144999724	144999724	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtggcctccaactgcaggCgcaccacgcggatctcctcc	6	6	11	18	4	1	0	0	0	1	0	4	1	3	1	5	4	2	2	5	4	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:144999724C>T	uc003zaf.1	-	31	4954	c.4784G>A	c.(4783-4785)CGC>CAC	p.R1595H	PLEC_uc003zab.1_Missense_Mutation_p.R1458H|PLEC_uc003zac.1_Missense_Mutation_p.R1462H|PLEC_uc003zad.2_Missense_Mutation_p.R1458H|PLEC_uc003zae.1_Missense_Mutation_p.R1426H|PLEC_uc003zag.1_Missense_Mutation_p.R1436H|PLEC_uc003zah.2_Missense_Mutation_p.R1444H|PLEC_uc003zaj.2_Missense_Mutation_p.R1485H	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1595	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CAACTGCAGGCGCACCACGCG	0.721													4	6					0	0	0	0	T	144999724	T	T	144999724	3	4	276	1	0	0	0	0	1	0	0	0	12107	768	27	1	9278	1	PLEC	8	144999724	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	58377	144999724	1364298	909	50798											
PLEC	5339	broad.mit.edu	37	chr8	145001818	145001818	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccgccagcgctccacctcCacgtcccgctccccgtgccg	3	6	8	24	6	0	0	0	0	0	0	5	0	5	0	9	0	2	2	9	0	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:145001818C>T	uc003zaf.1	-	27	4097	c.3927G>A	c.(3925-3927)GTG>GTA	p.V1309V	PLEC_uc003zab.1_Silent_p.V1172V|PLEC_uc003zac.1_Silent_p.V1176V|PLEC_uc003zad.2_Silent_p.V1172V|PLEC_uc003zae.1_Silent_p.V1140V|PLEC_uc003zag.1_Silent_p.V1150V|PLEC_uc003zah.2_Silent_p.V1158V|PLEC_uc003zaj.2_Silent_p.V1199V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1309	Globular 1.			V -> L (in Ref. 2; AAB05427/AAB05428).	cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCTCCACCTCCACGTCCCGCT	0.731													4	4					0	0	0	0	T	145001818	T	T	145001818	2	4	276	1	0	0	0	0	0	0	0	1	12107	581	21	4		4	PLEC	8	145001818	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2094	145001818	1362204	910	50799											
MFSD3	113655	broad.mit.edu	37	chr8	145735387	145735387	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacggcaggctttgtgctcaCctacaagctgggtgagtgag	8	9	15	9	1	1	2	1	2	0	0	1	3	1	2	1	3	3	4	1	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:145735387C>T	uc003zdi.1	+	1	836	c.671C>T	c.(670-672)ACC>ATC	p.T224I		NM_138431	NP_612440	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing	224	Leu-rich.|Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(2)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TTTGTGCTCACCTACAAGCTG	0.667											OREG0019059	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	15					0	0	0	0	T	145735387	T	T	145735387	3	4	276	1	0	0	0	0	1	0	0	0	9585	507	18	4	673	4	MFSD3	8	145735387	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	733569	145735387	628635	911	50800											
ZNF16	7564	broad.mit.edu	37	chr8	146171451	146171451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcagtatcactacagcaggGggtaccacaggctgcagatc	11	7	11	12	0	2	1	2	0	0	1	3	1	2	1	1	3	4	5	1	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr8:146171451G>A	uc003zet.2	-	3	329	c.142C>T	c.(142-144)CCC>TCC	p.P48S	ZNF16_uc003zeu.2_Missense_Mutation_p.P48S	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	48					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		CTACAGCAGGGGGTACCACAG	0.587													7	80					0	0	0	0	A	146171451	A	A	146171451	3	1	276	1	0	0	0	0	1	0	0	0	17805	1232	43	4	1914	4	ZNF16	8	146171451	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	436064	146171451	192571	912	50801											
KCNV2	169522	broad.mit.edu	37	chr9	2729471	2729471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catctccaccgtgggctacgGagacatgtacccagagaccc	10	6	10	15	2	1	2	0	0	1	2	2	4	1	2	4	2	2	2	4	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:2729471G>A	uc003zho.1	+	2	1596	c.1382G>A	c.(1381-1383)GGA>GAA	p.G461E		NM_133497	NP_598004	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	461	Selectivity filter (By similarity).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(50;0.0257)		GTGGGCTACGGAGACATGTAC	0.517													17	79					0	0	0	0	A	2729471	A	A	2729471	3	1	276	1	0	0	0	0	1	0	0	0	8134	1174	41	2	1388	2	KCNV2	9	2729471	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08		2729471	138483960	913	50802											
RFX3	5991	broad.mit.edu	37	chr9	3330439	3330439	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtagtcacctgggcggaactCccttgagtatcaaagtaatt	11	11	10	9	1	2	1	2	1	0	0	3	2	3	2	2	2	1	3	2	2	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:3330439C>T	uc003zhr.2	-	5	606	c.294G>A	c.(292-294)GGG>GGA	p.G98G	RFX3_uc010mhd.2_Silent_p.G98G|RFX3_uc003zhs.1_Silent_p.G98G|RFX3_uc003zht.1_Silent_p.G98G|RFX3_uc010mhe.1_Silent_p.G98G	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	98					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		GGGCGGAACTCCCTTGAGTAT	0.488													25	38					0	0	0	0	T	3330439	T	T	3330439	2	4	276	1	0	0	0	0	0	0	0	1	13329	842	30	2		2	RFX3	9	3330439	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	600968	3330439	137882992	914	50803											
ERMP1	79956	broad.mit.edu	37	chr9	5805208	5805208	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtaaaaagcaataaattttCcttgggcacctagggaaaaa	17	9	9	6	0	0	0	0	0	0	0	1	1	1	1	2	3	1	3	2	3	9	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:5805208C>T	uc003zjm.1	-	10	1787	c.1733G>A	c.(1732-1734)GGA>GAA	p.G578E	ERMP1_uc011lme.1_RNA|ERMP1_uc010mhs.1_Missense_Mutation_p.G192E	NM_024896	NP_079172	Q7Z2K6	ERMP1_HUMAN	aminopeptidase Fxna	578	Cytoplasmic (Potential).				proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			ovary(1)	1		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		AATAAATTTTCCTTGGGCACC	0.383													4	13					0	0	0	0	T	5805208	T	T	5805208	3	4	276	1	0	0	0	0	1	0	0	0	5260	855	30	2	1005	2	ERMP1	9	5805208	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2474769	5805208	135408223	915	50804											
KIAA2026	158358	broad.mit.edu	37	chr9	5968741	5968741	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctctttgtattttaatgggtGgaattggaaattctggggcc	8	16	12	5	0	2	0	0	0	2	0	2	2	2	2	1	5	0	1	1	5	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:5968741G>A	uc003zjq.3	-	3	1706	c.1490C>T	c.(1489-1491)CCA>CTA	p.P497L		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	497										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTTAATGGGTGGAATTGGAAA	0.378													46	88					0	0	0	0	A	5968741	A	A	5968741	3	1	276	1	0	0	0	0	1	0	0	0	8309	1348	47	4	4845	4	KIAA2026	9	5968741	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	163533	5968741	135244690	916	50805											
FREM1	158326	broad.mit.edu	37	chr9	14776177	14776177	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcaaacaccccgtgctcggtCcgcagtccattgctgatgat	8	10	9	14	3	1	2	1	2	0	0	4	2	3	2	4	1	3	3	4	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:14776177C>T	uc003zlm.2	-	25	5057	c.4467G>A	c.(4465-4467)CGG>CGA	p.R1489R	FREM1_uc010mic.2_Intron|FREM1_uc003zlk.2_5'Flank|FREM1_uc003zll.2_Silent_p.R25R	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1489	CSPG 11.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CGTGCTCGGTCCGCAGTCCAT	0.527													20	37					0	0	0	0	T	14776177	T	T	14776177	2	4	276	1	0	0	0	0	0	0	0	1	6078	842	30	2		2	FREM1	9	14776177	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	8807436	14776177	126437254	917	50806											
C9orf93	203238	broad.mit.edu	37	chr9	15971756	15971756	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acatttataaatactgtgccCcatgctctgacatcatctca	12	13	4	12	0	3	1	2	1	2	0	4	1	3	1	2	0	3	1	2	0	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:15971756C>T	uc003zmd.2	+	26	4218	c.3903C>T	c.(3901-3903)CCC>CCT	p.P1301P	C9orf93_uc003zme.2_Silent_p.P1216P|C9orf93_uc011lmu.1_Silent_p.P1309P	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	1301											0				GBM - Glioblastoma multiforme(50;4.84e-07)		ATACTGTGCCCCATGCTCTGA	0.388													101	59					0	0	0	0	T	15971756	T	T	15971756	2	4	276	1	0	0	0	0	0	0	0	1	2518	610	22	4		4	C9orf93	9	15971756	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1195579	15971756	125241675	918	50807											
BNC2	54796	broad.mit.edu	37	chr9	16437494	16437494	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctcgagacatgatggccCagcggtccagcaccttgcca	8	8	10	15	2	1	2	0	1	1	1	3	3	2	2	4	2	3	1	4	2	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:16437494C>T	uc003zml.2	-	6	838	c.698G>A	c.(697-699)TGG>TAG	p.W233*	BNC2_uc011lmw.1_Nonsense_Mutation_p.W138*|BNC2_uc003zmm.2_Nonsense_Mutation_p.W191*|BNC2_uc003zmq.1_Nonsense_Mutation_p.W247*|BNC2_uc003zmr.1_Nonsense_Mutation_p.W270*|BNC2_uc003zmp.1_Nonsense_Mutation_p.W261*|BNC2_uc010mij.1_Nonsense_Mutation_p.W155*|BNC2_uc011lmv.1_Nonsense_Mutation_p.W59*|BNC2_uc003zmo.1_Nonsense_Mutation_p.W155*|BNC2_uc003zmj.2_5'UTR|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_5'UTR|BNC2_uc003zmn.1_5'UTR	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		CATGATGGCCCAGCGGTCCAG	0.443													13	48					0	0	0	0	T	16437494	T	T	16437494	4	4	276	1	0	0	0	0	0	1	0	0	1478	595	21	4	2609	4	BNC2	9	16437494	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	465738	16437494	124775937	919	50808											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18675895	18675895	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgccttatgacctctaccatCcccttcctcggtacgtaaat	8	13	5	15	2	1	1	0	1	1	0	4	1	3	1	6	1	3	2	6	1	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:18675895C>T	uc003zne.3	+	10	1253	c.1126C>T	c.(1126-1128)CCC>TCC	p.P376S	ADAMTSL1_uc003znb.2_Intron|ADAMTSL1_uc003znc.3_Missense_Mutation_p.P376S	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	376	TSP type-1 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CCTCTACCATCCCCTTCCTCG	0.368													11	46					0	0	0	0	T	18675895	T	T	18675895	3	4	276	1	0	0	0	0	1	0	0	0	274	855	30	2	1164	2	ADAMTSL1	9	18675895	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2238401	18675895	122537536	920	50809											
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	4	6	23	8	6	0	1	0	1	0	1	3	2	0	1	0	7	2	2	0	7	0	0	rs121913388		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			12	15					0	0	0	0	A	21971120	A	A	21971120	4	1	276	1	0	0	0	0	0	1	0	0	3176	1125	39	1	240	1	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3295225	21971120	119242311	921	50810											
MOBKL2B	79817	broad.mit.edu	37	chr9	27359212	27359212	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atcttcttgcagatctgaagGaagttctttgggaagggaac	11	12	12	6	0	4	2	0	1	4	1	4	5	4	5	0	3	2	2	0	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:27359212G>A	uc003zqn.2	-	3	937	c.441C>T	c.(439-441)TTC>TTT	p.F147F		NM_024761	NP_079037	Q86TA1	MOL2B_HUMAN	MOB1, Mps One Binder kinase activator-like 2B	147							metal ion binding|protein binding			ovary(1)|pleura(1)	2		all_neural(11;9.12e-11)		Lung(218;6.54e-05)|LUSC - Lung squamous cell carcinoma(38;0.000397)		AGATCTGAAGGAAGTTCTTTG	0.458													35	161					0	0	0	0	A	27359212	A	A	27359212	2	1	276	1	0	0	0	0	0	0	0	1	9738	1165	41	2		2	MOBKL2B	9	27359212	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5388092	27359212	113854219	922	50811											
TAF1L	138474	broad.mit.edu	37	chr9	32632800	32632800	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttcttctggggcaaaaaaGgatttctcaccatagccagc	11	11	8	11	0	4	0	1	0	4	0	5	1	4	1	2	3	2	1	2	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:32632800G>A	uc003zrg.1	-	1	2868	c.2778C>T	c.(2776-2778)TCC>TCT	p.S926S	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	926					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGGCAAAAAAGGATTTCTCAC	0.453													16	131					0	0	0	0	A	32632800	A	A	32632800	2	1	276	1	0	0	0	0	0	0	0	1	15589	987	35	4		4	TAF1L	9	32632800	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5273588	32632800	108580631	923	50812											
NOL6	65083	broad.mit.edu	37	chr9	33467448	33467449	+	Missense_Mutation	DNP	GG	AA	AA																															gctggtcagtccctcaggccGgagaaggagtcccagggtca																								rs115753355	by1000genomes	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:33467448_33467449GG>AA	uc003zsz.2	-	13	1769_1770	c.1668_1669CC>TT	c.(1666-1671)CTCCGG>CTTTGG	p.R557W	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'Flank|NOL6_uc003zta.2_Missense_Mutation_p.R557W|NOL6_uc010mjv.2_Missense_Mutation_p.R554W|NOL6_uc011lob.1_Missense_Mutation_p.R505W|NOL6_uc003ztb.1_Missense_Mutation_p.R557W	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	557					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		CCCTCAGGCCGGAGAAGGAGTC	0.599											OREG0019137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	27					0	0	0	0	AA	33467449	AA	AA	33467448	3	1	276	1	0	0	0	0	1	0	0	0	10579	1115	39	1	1827	1	NOL6	9	33467448	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	834648	33467448	107745983	924	50813											
UBAP2	55833	broad.mit.edu	37	chr9	33922871	33922871	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatgaaatccctgcttgtcAaaagtctacagggcaaagaa	15	8	9	9	0	2	2	1	1	1	1	3	2	3	2	1	1	2	3	1	1	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:33922871A>T	uc003ztq.1	-	28	3191	c.3078T>A	c.(3076-3078)TTT>TTA	p.F1026L	UBAP2_uc011loc.1_Missense_Mutation_p.F935L|UBAP2_uc011lod.1_Missense_Mutation_p.F759L|UBAP2_uc011loe.1_Missense_Mutation_p.F781L|UBAP2_uc003ztn.1_Missense_Mutation_p.F265L|UBAP2_uc003zto.1_Missense_Mutation_p.F265L|UBAP2_uc003ztp.1_Missense_Mutation_p.F265L	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	1026										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		CCTGCTTGTCAAAAGTCTACA	0.572													55	28					0	0	0	0	T	33922871	T	T	33922871	3	4	276	1	0	0	0	0	1	0	0	0	16905	127	5	5	289	5	UBAP2	9	33922871	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	455423	33922871	107290560	925	50814											
C9orf131	138724	broad.mit.edu	37	chr9	35045473	35045473	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaaaagagagagcaccctagGaaacccaaagcaggagacca	20	1	10	10	0	0	3	0	0	0	3	0	6	0	4	3	2	3	2	3	2	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:35045473G>A	uc003zvw.2	+	2	2876	c.2847G>A	c.(2845-2847)AGG>AGA	p.R949R	C9orf131_uc003zvu.2_Silent_p.R901R|C9orf131_uc003zvv.2_Silent_p.R876R|C9orf131_uc003zvx.2_Silent_p.R914R	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	949											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			AGCACCCTAGGAAACCCAAAG	0.542													19	145					0	0	0	0	A	35045473	A	A	35045473	2	1	276	1	0	0	0	0	0	0	0	1	2469	1165	41	2		2	C9orf131	9	35045473	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1122602	35045473	106167958	926	50815											
UNC13B	10497	broad.mit.edu	37	chr9	35243343	35243343	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgggagcaaatcaatgcCttgggagctgacaatgaggt	14	8	13	6	0	1	2	1	2	0	0	1	4	1	4	1	3	3	2	1	3	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:35243343C>T	uc003zwq.2	+	6	742	c.450C>T	c.(448-450)GCC>GCT	p.A150A	UNC13B_uc010mkl.1_Silent_p.A150A|UNC13B_uc003zwr.2_Silent_p.A150A	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	150					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			AAATCAATGCCTTGGGAGCTG	0.443													25	131					0	0	0	0	T	35243343	T	T	35243343	2	4	276	1	0	0	0	0	0	0	0	1	17053	668	24	4		4	UNC13B	9	35243343	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	197870	35243343	105970088	927	50816											
RECK	8434	broad.mit.edu	37	chr9	36102140	36102140	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtggagaccagaacaaattcCctgaagaccacacagctgaa	16	5	9	11	0	0	5	0	2	0	3	1	6	1	5	3	1	2	1	3	1	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:36102140C>T	uc003zyv.2	+	12	1434	c.1348C>T	c.(1348-1350)CCT>TCT	p.P450S	RECK_uc003zyw.2_Missense_Mutation_p.P322S|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	450						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GAACAAATTCCCTGAAGACCA	0.373													13	76					0	0	0	0	T	36102140	T	T	36102140	3	4	276	1	0	0	0	0	1	0	0	0	13265	623	22	4	1394	4	RECK	9	36102140	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	858797	36102140	105111291	928	50817											
PAX5	5079	broad.mit.edu	37	chr9	37014993	37014993	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacaggcacgagcccctcaCctgttgatggaactgacgct	9	7	10	15	2	1	2	1	2	0	0	1	4	1	3	4	2	2	3	4	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:37014993C>T	uc003zzo.1	-	3	858	c.410_splice	c.e3+1	p.R137_splice	PAX5_uc011lpw.1_Splice_Site_p.R137_splice|PAX5_uc011lpx.1_Intron|PAX5_uc011lpy.1_Splice_Site_p.R29_splice|PAX5_uc010mls.1_Splice_Site_p.R137_splice|PAX5_uc011lpz.1_Splice_Site_p.R137_splice|PAX5_uc011lqa.1_Splice_Site_p.R29_splice|PAX5_uc010mlq.1_Splice_Site|PAX5_uc011lqb.1_Splice_Site|PAX5_uc010mlo.1_Splice_Site_p.R137_splice|PAX5_uc010mlp.1_Splice_Site_p.R137_splice|PAX5_uc011lqc.1_Splice_Site_p.R137_splice|PAX5_uc010mlr.1_Splice_Site_p.R137_splice|PAX5_uc011lqd.1_Intron|PAX5_uc011lqe.1_Splice_Site|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_Splice_Site	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5						cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(29)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		GAGCCCCTCACCTGTTGATGG	0.577			T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								34	172					0	0	0	0	T	37014993	T	T	37014993	5	4	276	1	0	0	0	0	0	0	1	0	11536	521	18	4	796	4	PAX5	9	37014993	Splice_Site	SNP	C	TCGA-D6-6516-01A-11D-1870-08	912853	37014993	104198438	929	50818											
FBXO10	26267	broad.mit.edu	37	chr9	37537656	37537656	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtccagggacattaaaaaGtcagagtcctctgtggggag	12	8	14	7	0	2	1	1	0	1	1	4	3	4	3	2	4	0	0	2	4	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:37537656G>A	uc004aab.2	-	3	919	c.870C>T	c.(868-870)GAC>GAT	p.D290D	FBXO10_uc004aac.2_Silent_p.D306D|FBXO10_uc004aad.2_Intron	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	290						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		ACATTAAAAAGTCAGAGTCCT	0.542													6	40					0	0	0	0	A	37537656	A	A	37537656	2	1	276	1	0	0	0	0	0	0	0	1	5758	1020	36	4		4	FBXO10	9	37537656	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	522663	37537656	103675775	930	50819											
ALDH1B1	219	broad.mit.edu	37	chr9	38396326	38396326	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccttggtcatgcagggttGgaaacttgccccggcactcg	6	9	12	14	2	1	0	1	0	0	0	2	1	1	1	4	4	3	3	4	4	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:38396326G>A	uc004aay.2	+	2	693	c.581G>A	c.(580-582)TGG>TAG	p.W194*		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	194					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	ATGCAGGGTTGGAAACTTGCC	0.587													15	87					0	0	0	0	A	38396326	A	A	38396326	4	1	276	1	0	0	0	0	0	1	0	0	493	1357	47	4	583	4	ALDH1B1	9	38396326	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	858670	38396326	102817105	931	50820											
FAM75A6	389730	broad.mit.edu	37	chr9	43624966	43624966	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtggttgcagggaaaccCacagactggggcttgaaact	10	8	13	10	0	0	2	0	1	0	1	0	3	0	3	2	4	3	3	2	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:43624966C>T	uc011lrb.1	-	4	3750	c.3721G>A	c.(3721-3723)GGG>AGG	p.G1241R		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1241						integral to membrane					0						CAGGGAAACCCACAGACTGGG	0.507													37	405					0	0	0	0	T	43624966	T	T	43624966	3	4	276	1	0	0	0	0	1	0	0	0	5654	594	21	4	314	4	FAM75A6	9	43624966	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5228640	43624966	97588465	932	50821											
C9orf135	138255	broad.mit.edu	37	chr9	72459528	72459528	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aacatatcggcgactgggaaCcgatgaatccccagtaagta	14	7	10	10	3	0	1	0	1	0	0	2	4	1	2	3	2	2	2	3	2	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:72459528C>T	uc004ahl.2	+	2	313	c.248C>T	c.(247-249)ACC>ATC	p.T83I	C9orf135_uc011lrw.1_Intron|C9orf135_uc010moq.2_Intron|C9orf135_uc011lrx.1_Intron|C9orf135_uc010mop.2_Missense_Mutation_p.T83I	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255	83	Extracellular (Potential).					integral to membrane				ovary(1)	1						CGACTGGGAACCGATGAATCC	0.393													42	73					0	0	0	0	T	72459528	T	T	72459528	3	4	276	1	0	0	0	0	1	0	0	0	2470	507	18	4	254	4	C9orf135	9	72459528	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	28834562	72459528	68753903	933	50822											
TRPM3	80036	broad.mit.edu	37	chr9	73477822	73477822	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aactgaatggctttctgattAccatggctttgttggaatgg	9	15	11	6	0	1	2	0	2	1	0	1	3	1	3	1	4	2	3	1	4	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:73477822A>T	uc004aid.2	-	3	706	c.462_splice	c.e3+1	p.M154_splice	TRPM3_uc004ahw.2_Splice_Site_p.M1_splice|TRPM3_uc004ahx.2_Splice_Site_p.M1_splice|TRPM3_uc004ahy.2_Splice_Site_p.M1_splice|TRPM3_uc004ahz.2_Splice_Site_p.M1_splice|TRPM3_uc004aia.2_Splice_Site_p.M1_splice|TRPM3_uc004aib.2_Splice_Site_p.M1_splice|TRPM3_uc004aic.2_Splice_Site_p.M154_splice|TRPM3_uc010mor.2_Splice_Site_p.M154_splice|TRPM3_uc004aie.2_Splice_Site_p.M1_splice|TRPM3_uc004aif.2_Splice_Site_p.M1_splice|TRPM3_uc004aig.2_Splice_Site_p.M1_splice|TRPM3_uc004aii.2_Splice_Site_p.M156_splice	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,							integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CTTTCTGATTACCATGGCTTT	0.383													19	154					0	0	0	0	T	73477822	T	T	73477822	5	4	276	1	0	0	0	0	0	0	1	0	16654	405	14	5	4874	5	TRPM3	9	73477822	Splice_Site	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1018294	73477822	67735609	934	50823											
GCNT1	2650	broad.mit.edu	37	chr9	79117759	79117759	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatttctattgcattcatgtGgacacaaaatccgaggattc	13	13	7	8	1	2	0	1	0	1	0	4	3	3	2	1	2	1	1	1	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:79117759G>A	uc010mpf.2	+	3	803	c.462G>A	c.(460-462)GTG>GTA	p.V154V	GCNT1_uc010mpg.2_Silent_p.V154V|GCNT1_uc010mph.2_Silent_p.V154V|GCNT1_uc004akf.3_Silent_p.V154V|GCNT1_uc010mpi.2_Silent_p.V154V|GCNT1_uc004akh.3_Silent_p.V154V	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	154	Lumenal (Potential).|Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						GCATTCATGTGGACACAAAAT	0.428													42	70					0	0	0	0	A	79117759	A	A	79117759	2	1	276	1	0	0	0	0	0	0	0	1	6335	1335	47	4		4	GCNT1	9	79117759	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5639937	79117759	62095672	935	50824											
GCNT1	2650	broad.mit.edu	37	chr9	79117926	79117927	+	Nonsense_Mutation	DNP	GG	AA	AA																															ctatgcaatgagtgcaaactGgaagtacttgataaatcttt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:79117926_79117927GG>AA	uc010mpf.2	+	3	970_971	c.629_630GG>AA	c.(628-630)TGG>TAA	p.W210*	GCNT1_uc010mpg.2_Nonsense_Mutation_p.W210*|GCNT1_uc010mph.2_Nonsense_Mutation_p.W210*|GCNT1_uc004akf.3_Nonsense_Mutation_p.W210*|GCNT1_uc010mpi.2_Nonsense_Mutation_p.W210*|GCNT1_uc004akh.3_Nonsense_Mutation_p.W210*	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	210	Lumenal (Potential).|Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						AGTGCAAACTGGAAGTACTTGA	0.436													18	89					0	0	0	0	AA	79117927	AA	AA	79117926	4	1	276	1	0	0	0	0	0	1	0	0	6335	1357	47	4	631	4	GCNT1	9	79117926	Nonsense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	167	79117926	62095505	936	50825											
PRUNE2	158471	broad.mit.edu	37	chr9	79322795	79322795	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agaaagttacattcttcagtTttctcaagatccttttcagg	11	16	6	8	0	4	2	3	0	2	2	6	2	5	2	1	1	1	2	1	1	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:79322795T>A	uc010mpk.2	-	8	4519	c.4395A>T	c.(4393-4395)AAA>AAT	p.K1465N		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1465					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ATTCTTCAGTTTTCTCAAGAT	0.433													20	88					0	0	0	0	A	79322795	A	A	79322795	3	1	276	1	0	0	0	0	1	0	0	0	12703	1838	64	5	4919	5	PRUNE2	9	79322795	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	204869	79322795	61890636	937	50826											
TLE4	7091	broad.mit.edu	37	chr9	82267635	82267635	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgccgggcttctggccctctCcagtgctctaggaggtcagt	4	11	13	13	1	4	0	1	0	3	0	5	1	4	1	3	4	2	2	3	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:82267635C>T	uc004ald.2	+	7	1346	c.497C>T	c.(496-498)TCC>TTC	p.S166F	TLE4_uc004alc.2_Missense_Mutation_p.S173F|TLE4_uc010mpr.2_Missense_Mutation_p.S52F|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Missense_Mutation_p.S141F|TLE4_uc010mps.2_Missense_Mutation_p.S166F|TLE4_uc004alf.2_Missense_Mutation_p.S112F	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CTGGCCCTCTCCAGTGCTCTA	0.542													67	120					0	0	0	0	T	82267635	T	T	82267635	3	4	276	1	0	0	0	0	1	0	0	0	16007	855	30	2	544	2	TLE4	9	82267635	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2944840	82267635	58945796	938	50827											
FLJ46321	389763	broad.mit.edu	37	chr9	84606513	84606513	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattttgtgccatctgatttCatggaggagcttcttaccct	8	16	8	9	0	3	1	1	1	2	0	3	3	3	3	2	2	3	1	2	2	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:84606513C>T	uc004amn.2	+	4	1175	c.1128C>T	c.(1126-1128)TTC>TTT	p.F376F		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	376						integral to membrane					0						CATCTGATTTCATGGAGGAGC	0.468													30	54					0	0	0	0	T	84606513	T	T	84606513	2	4	276	1	0	0	0	0	0	0	0	1	5964	825	29	2		2	FLJ46321	9	84606513	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2338878	84606513	56606918	939	50828											
FLJ46321	389763	broad.mit.edu	37	chr9	84607526	84607526	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagtctctgtcattgctacGtcctcagagcaaaatttcag	10	13	8	10	1	4	2	3	1	1	1	6	2	5	2	1	0	3	2	1	0	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:84607526G>A	uc004amn.2	+	4	2188	c.2141G>A	c.(2140-2142)CGT>CAT	p.R714H		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	714						integral to membrane					0						TCATTGCTACGTCCTCAGAGC	0.473													14	66					0	0	0	0	A	84607526	A	A	84607526	3	1	276	1	0	0	0	0	1	0	0	0	5964	1145	40	1	2155	1	FLJ46321	9	84607526	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1013	84607526	56605905	940	50829											
FRMD3	257019	broad.mit.edu	37	chr9	85862842	85862842	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agagattaacttcatgagcaAcccagcatgtagaggatgag	15	8	11	7	0	1	4	1	2	0	2	1	6	1	5	1	1	4	3	1	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:85862842A>G	uc004ams.1	-	14	1987	c.1785T>C	c.(1783-1785)GGT>GGC	p.G595G	FRMD3_uc004amr.1_Intron|FRMD3_uc004amq.1_Intron	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	595						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						TTCATGAGCAACCCAGCATGT	0.478													95	247					0	0	0	0	G	85862842	G	G	85862842	2	3	276	1	0	0	0	0	0	0	0	1	6084	30	2	5		5	FRMD3	9	85862842	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1255316	85862842	55350589	941	50830											
HNRNPK	3190	broad.mit.edu	37	chr9	86586945	86586945	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggaggcatgggacgcccacCccgaccaggaggcattctgt	8	6	14	13	2	1	0	0	0	1	0	1	4	1	3	4	5	0	2	4	5	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:86586945C>T	uc004ang.3	-	11	1029	c.805G>A	c.(805-807)GGT>AGT	p.G269S	HNRNPK_uc011lsw.1_Missense_Mutation_p.G29S|HNRNPK_uc004and.3_Missense_Mutation_p.G29S|HNRNPK_uc004ank.3_Missense_Mutation_p.G269S|HNRNPK_uc004anf.3_Missense_Mutation_p.G269S|HNRNPK_uc004anh.3_Missense_Mutation_p.G245S|HNRNPK_uc011lsx.1_Missense_Mutation_p.G245S|HNRNPK_uc004ani.3_Missense_Mutation_p.G269S|HNRNPK_uc004anj.3_Missense_Mutation_p.G269S|HNRNPK_uc004ann.3_Missense_Mutation_p.G245S|HNRNPK_uc004anl.3_Missense_Mutation_p.G269S|HNRNPK_uc004anm.3_Missense_Mutation_p.G269S|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	269	5 X 4 AA repeats of G-X-G-G.|2 X 22 AA approximate repeats.|RNA-binding RGG-box.|2 X 6 AA approximate repeats.|Necessary for interaction with DDX1.|3-3.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						GGACGCCCACCCCGACCAGGA	0.582													14	89					0	0	0	0	T	86586945	T	T	86586945	3	4	276	1	0	0	0	0	1	0	0	0	7308	623	22	4	652	4	HNRNPK	9	86586945	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	724103	86586945	54626486	942	50831											
ZCCHC6	79670	broad.mit.edu	37	chr9	88960644	88960644	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcaaatgcaatggattcAattaaaacatcacagagtct	16	10	8	7	0	3	1	2	0	1	1	3	2	3	2	0	2	2	2	0	2	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:88960644A>C	uc004aoq.2	-	4	974	c.759T>G	c.(757-759)ATT>ATG	p.I253M	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.I253M|ZCCHC6_uc004aou.2_Missense_Mutation_p.I253M|ZCCHC6_uc004aov.2_Missense_Mutation_p.I253M|ZCCHC6_uc004aow.2_Missense_Mutation_p.I253M	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	253					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						CAATGGATTCAATTAAAACAT	0.353													13	79					0	0	0	0	C	88960644	C	C	88960644	3	2	276	1	0	0	0	0	1	0	0	0	17659	126	5	5	3824	5	ZCCHC6	9	88960644	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	2373699	88960644	52252787	943	50832											
DAPK1	1612	broad.mit.edu	37	chr9	90272959	90272959	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccagtatgggcgaacgcctCtgcaccttgcggccaacaac	9	6	10	16	3	1	0	0	0	1	0	1	1	1	0	4	2	5	2	4	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:90272959C>T	uc004apc.2	+	18	1978	c.1840C>T	c.(1840-1842)CTG>TTG	p.L614L	DAPK1_uc004apd.2_Silent_p.L614L|DAPK1_uc011ltg.1_Silent_p.L614L|DAPK1_uc011lth.1_Silent_p.L351L|DAPK1_uc004apf.1_Silent_p.L168L	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	614	ANK 8.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						GCGAACGCCTCTGCACCTTGC	0.567									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				7	16					0	0	0	0	T	90272959	T	T	90272959	2	4	276	1	0	0	0	0	0	0	0	1	4252	912	32	2		2	DAPK1	9	90272959	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1312315	90272959	50940472	944	50833											
DAPK1	1612	broad.mit.edu	37	chr9	90296363	90296363	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcagctccgacccacacaGaacctgcagccaagaattaa	15	4	7	15	1	0	2	0	0	0	2	1	3	1	2	4	0	5	3	4	0	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:90296363G>C	uc004apc.2	+	20	2184	c.2046G>C	c.(2044-2046)CAG>CAC	p.Q682H	DAPK1_uc004apd.2_Missense_Mutation_p.Q682H|DAPK1_uc011ltg.1_Missense_Mutation_p.Q682H|DAPK1_uc011lth.1_Missense_Mutation_p.Q419H|DAPK1_uc004apf.1_Missense_Mutation_p.Q236H	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	682					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						GACCCACACAGAACCTGCAGC	0.502									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				35	182					0	0	0	0	C	90296363	C	C	90296363	3	2	276	1	0	0	0	0	1	0	0	0	4252	933	33	2	2120	2	DAPK1	9	90296363	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	23404	90296363	50917068	945	50834											
DIRAS2	54769	broad.mit.edu	37	chr9	93375903	93375903	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggacagccgctgcatggcCgggaactggtggctccccgt	6	7	15	13	3	0	0	0	0	0	0	1	2	1	2	4	5	3	3	4	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:93375903C>T	uc004aqx.1	-	2	318	c.207G>A	c.(205-207)CCG>CCA	p.P69P		NM_017594	NP_060064	Q96HU8	DIRA2_HUMAN	Di-Ras2	69					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity				0						GCTGCATGGCCGGGAACTGGT	0.577													34	85					0	0	0	0	T	93375903	T	T	93375903	2	4	276	1	0	0	0	0	0	0	0	1	4553	639	23	1		1	DIRAS2	9	93375903	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3079540	93375903	47837528	946	50835											
AUH	549	broad.mit.edu	37	chr9	94087606	94087606	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttaatagtgcttaccaatatCgttaatcactgctcttattt	11	18	4	8	1	2	0	1	0	1	0	3	0	2	0	1	0	3	3	1	0	7	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:94087606C>T	uc004arf.3	-	4	534	c.499G>A	c.(499-501)GAT>AAT	p.D167N	AUH_uc004arg.3_Intron|AUH_uc011ltu.1_Missense_Mutation_p.D167N	NM_001698	NP_001689	Q13825	AUHM_HUMAN	AU RNA binding protein/enoyl-Coenzyme A	167					branched chain family amino acid catabolic process|mRNA catabolic process	mitochondrial matrix	enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mRNA 3'-UTR binding				0						TTACCAATATCGTTAATCACT	0.343													28	103					0	0	0	0	T	94087606	T	T	94087606	3	4	276	1	0	0	0	0	1	0	0	0	1221	884	31	1	548	1	AUH	9	94087606	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	711703	94087606	47125825	947	50836											
IARS	3376	broad.mit.edu	37	chr9	95030486	95030486	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcatcgctgacccacagtggGatgggggtgccccagtatct	7	9	13	12	1	2	1	1	1	1	0	3	2	2	2	3	3	1	2	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:95030486G>A	uc004art.1	-	14	1658	c.1401C>T	c.(1399-1401)ATC>ATT	p.I467I	IARS_uc004ars.1_Silent_p.I312I|IARS_uc004aru.3_Silent_p.I467I|IARS_uc010mqr.2_Silent_p.I357I|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	467					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	CCCACAGTGGGATGGGGGTGC	0.463													47	242					0	0	0	0	A	95030486	A	A	95030486	2	1	276	1	0	0	0	0	0	0	0	1	7512	1164	41	2		2	IARS	9	95030486	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	942880	95030486	46182945	948	50837											
ZNF484	83744	broad.mit.edu	37	chr9	95610131	95610131	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctgacggtttgacttgaggGaaaaatccttctcatattca	11	14	8	8	1	3	3	2	3	2	0	5	4	4	4	1	2	0	1	1	2	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:95610131G>A	uc004asu.1	-	5	1087	c.938C>T	c.(937-939)TCC>TTC	p.S313F	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Missense_Mutation_p.S315F|ZNF484_uc010mrb.1_Missense_Mutation_p.S277F|ZNF484_uc004asv.1_Missense_Mutation_p.S277F	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGACTTGAGGGAAAAATCCTT	0.433													35	67					0	0	0	0	A	95610131	A	A	95610131	3	1	276	1	0	0	0	0	1	0	0	0	18004	1174	41	2	1624	2	ZNF484	9	95610131	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	579645	95610131	45603300	949	50838											
C9orf3	84909	broad.mit.edu	37	chr9	97522670	97522670	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaaatcgttggagggagcAgttagactattacgctcgct	10	11	12	8	3	0	1	0	0	0	1	2	3	0	3	0	2	3	6	0	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:97522670A>T	uc004ava.2	+	1	740	c.605A>T	c.(604-606)CAG>CTG	p.Q202L	C9orf3_uc011lui.1_RNA|C9orf3_uc004aux.1_Missense_Mutation_p.Q202L|C9orf3_uc004auy.2_Missense_Mutation_p.Q202L|C9orf3_uc004auz.1_Missense_Mutation_p.Q202L	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	202					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		TGGAGGGAGCAGTTAGACTAT	0.502													16	66					0	0	0	0	T	97522670	T	T	97522670	3	4	276	1	0	0	0	0	1	0	0	0	2489	188	7	5	607	5	C9orf3	9	97522670	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1912539	97522670	43690761	950	50839											
ZNF510	22869	broad.mit.edu	37	chr9	99525461	99525461	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctcctctccttgctccaaCttgaagatcacctctggttt	6	14	7	14	0	3	2	1	1	2	1	6	2	5	2	4	2	2	3	4	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:99525461C>A	uc004awn.1	-	5	480	c.291G>T	c.(289-291)AAG>AAT	p.K97N	ZNF510_uc004awo.1_Missense_Mutation_p.K97N	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	97	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				CTTGCTCCAACTTGAAGATCA	0.433													89	188					3.29526e-42	3.44184e-42	1	0	A	99525461	A	A	99525461	3	1	276	1	0	0	0	0	1	0	0	0	18021	564	20	4	1768	4	ZNF510	9	99525461	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2002791	99525461	41687970	951	50840											
KIAA1529	57653	broad.mit.edu	37	chr9	100126386	100126386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gagaaagtaccgggtgcttgGggacaagcctccccctgctg	8	7	14	12	1	0	1	0	0	0	1	1	3	1	2	4	3	4	3	4	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:100126386G>A	uc011lut.1	+	41	5278	c.4505G>A	c.(4504-4506)GGG>GAG	p.G1502E	KIAA1529_uc004axe.1_Missense_Mutation_p.G1308E|KIAA1529_uc004axg.1_Missense_Mutation_p.G1363E|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Intron|MIR1302-8_hsa-mir-1302-8|MI0006369_5'Flank	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				CGGGTGCTTGGGGACAAGCCT	0.562													5	34					0	0	0	0	A	100126386	A	A	100126386	3	1	276	1	0	0	0	0	1	0	0	0	8279	1232	43	4	4041	4	KIAA1529	9	100126386	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	600925	100126386	41087045	952	50841											
C9orf156	51531	broad.mit.edu	37	chr9	100672660	100672660	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaggacatttaggtttcctCttagtgctatggtggggttg	6	16	13	6	0	2	0	1	0	1	0	3	1	3	1	1	5	1	3	1	5	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:100672660C>T	uc004axv.1	-	4	725	c.648G>A	c.(646-648)AAG>AAA	p.K216K	C9orf156_uc004axw.1_Silent_p.K113K|C9orf156_uc004axx.1_Silent_p.K70K|C9orf156_uc010msq.1_Silent_p.K113K	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	216					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				TAGGTTTCCTCTTAGTGCTAT	0.488													22	90					0	0	0	0	T	100672660	T	T	100672660	2	4	276	1	0	0	0	0	0	0	0	1	2477	912	32	2		2	C9orf156	9	100672660	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	546274	100672660	40540771	953	50842											
TRIM14	9830	broad.mit.edu	37	chr9	100857229	100857229	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccttaaagaagctcttgacgGgctcaaaggagaggggcacg	12	6	14	9	2	2	3	1	1	1	2	2	4	2	3	1	4	1	3	1	4	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:100857229G>A	uc004ayd.2	-	4	638	c.620C>T	c.(619-621)CCC>CTC	p.P207L	TRIM14_uc004ayf.1_Missense_Mutation_p.P114L|TRIM14_uc011luz.1_5'Flank|TRIM14_uc011lva.1_5'Flank|TRIM14_uc004ayg.1_Missense_Mutation_p.P207L|TRIM14_uc004ayh.1_Missense_Mutation_p.P207L|TRIM14_uc004ayi.1_Missense_Mutation_p.P207L|TRIM14_uc004ayj.1_Missense_Mutation_p.P114L	NM_033220	NP_150089	Q14142	TRI14_HUMAN	tripartite motif protein TRIM14 isoform alpha	207						cytoplasm|intracellular	zinc ion binding	p.P207L(1)		central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GCTCTTGACGGGCTCAAAGGA	0.587													20	125					0	0	0	0	A	100857229	A	A	100857229	3	1	276	1	0	0	0	0	1	0	0	0	16556	1232	43	4	720	4	TRIM14	9	100857229	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	184569	100857229	40356202	954	50843											
GABBR2	9568	broad.mit.edu	37	chr9	101340229	101340229	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaccttacctgcaccagattCcagccttggagggactctgc	8	9	10	14	0	1	1	0	0	1	1	2	4	2	3	5	2	4	1	5	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:101340229C>T	uc004ays.2	-	2	603	c.447G>A	c.(445-447)TGG>TGA	p.W149*		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	149	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GCACCAGATTCCAGCCTTGGA	0.488													8	71					0	0	0	0	T	101340229	T	T	101340229	4	4	276	1	0	0	0	0	0	1	0	0	6190	856	30	2	2450	2	GABBR2	9	101340229	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	483000	101340229	39873202	955	50844											
NR4A3	8013	broad.mit.edu	37	chr9	102626030	102626030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccaaggtcctgggtgccctgGtagaactgaggaagatctgc	9	8	14	10	0	1	3	0	1	1	2	2	4	2	4	3	4	3	1	3	4	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:102626030G>A	uc004baf.1	+	8	2491	c.1762G>A	c.(1762-1764)GTA>ATA	p.V588I	NR4A3_uc004bag.1_Missense_Mutation_p.V588I|NR4A3_uc004bai.2_Missense_Mutation_p.V599I	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	588					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				GGGTGCCCTGGTAGAACTGAG	0.532			T	EWSR1	extraskeletal myxoid chondrosarcoma								18	28					0	0	0	0	A	102626030	A	A	102626030	3	1	276	1	0	0	0	0	1	0	0	0	10688	1261	44	4	1899	4	NR4A3	9	102626030	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1285801	102626030	38587401	956	50845											
GRIN3A	116443	broad.mit.edu	37	chr9	104375660	104375660	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcaacagtctttccatacctCcgtgacagcaaaacttctct	11	12	4	14	1	3	1	1	1	2	0	6	1	5	1	3	0	4	1	3	0	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:104375660C>T	uc004bbp.1	-	6	3365	c.2764G>A	c.(2764-2766)GAG>AAG	p.E922K	GRIN3A_uc004bbq.1_Missense_Mutation_p.E922K	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	922	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TTCCATACCTCCGTGACAGCA	0.433													12	60					0	0	0	0	T	104375660	T	T	104375660	3	4	276	1	0	0	0	0	1	0	0	0	6822	864	30	2	599	2	GRIN3A	9	104375660	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1749630	104375660	36837771	957	50846											
OR13D1	286365	broad.mit.edu	37	chr9	107456851	107456851	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	attctttctggtggggctttCccaatatccagagctccagc	7	13	9	12	0	2	1	0	0	2	1	5	1	5	1	3	3	2	2	3	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:107456851C>T	uc011lvs.1	+	1	149	c.149C>T	c.(148-150)TCC>TTC	p.S50F		NM_001004484	NP_001004484	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D,	50	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GTGGGGCTTTCCCAATATCCA	0.448													24	85					0	0	0	0	T	107456851	T	T	107456851	3	4	276	1	0	0	0	0	1	0	0	0	10994	855	30	2	151	2	OR13D1	9	107456851	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3081191	107456851	33756580	958	50847											
ACTL7B	10880	broad.mit.edu	37	chr9	111617981	111617981	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcagcgtttgcccacggtgGaggagatgaagtaggtgggc	8	7	19	7	2	0	2	0	1	0	1	0	4	0	3	1	6	2	3	1	6	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:111617981G>A	uc004bdi.2	-	1	295	c.230C>T	c.(229-231)TCC>TTC	p.S77F		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	77						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						GCCCACGGTGGAGGAGATGAA	0.637													20	138					0	0	0	0	A	111617981	A	A	111617981	3	1	276	1	0	0	0	0	1	0	0	0	201	1174	41	2	1021	2	ACTL7B	9	111617981	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4161130	111617981	29595450	959	50848											
EPB41L4B	54566	broad.mit.edu	37	chr9	112018730	112018731	+	Missense_Mutation	DNP	GG	AA	AA																															cacttcgctttattcagataGgagagttccgcctgggcagg																								rs144325998	by1000genomes	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:112018730_112018731GG>AA	uc004bdz.1	-	8	1077_1078	c.782_783CC>TT	c.(781-783)TCC>TTT	p.S261F	EPB41L4B_uc004bea.2_Missense_Mutation_p.S261F	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	261	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						TATTCAGATAGGAGAGTTCCGC	0.47													24	123					0	0	0	0	AA	112018731	AA	AA	112018730	3	1	276	1	0	0	0	0	1	0	0	0	5180	987	35	4	2147	4	EPB41L4B	9	112018730	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	400749	112018730	29194701	960	50849											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112898501	112898501	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcctgctgccagctctctttCcccagatcacaaaaacatgg	10	9	7	15	0	2	1	1	0	1	1	4	1	3	1	4	1	4	2	4	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:112898501C>T	uc004bei.2	+	9	1565	c.1373C>T	c.(1372-1374)TCC>TTC	p.S458F	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.S226F|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.S226F|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.S36F|AKAP2_uc011lwi.1_Missense_Mutation_p.S84F|AKAP2_uc004bem.2_Missense_Mutation_p.S84F|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.S44F|AKAP2_uc011lwj.1_5'UTR|PALM2-AKAP2_uc004ben.2_5'UTR	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AGCTCTCTTTCCCCAGATCAC	0.507													35	124					0	0	0	0	T	112898501	T	T	112898501	3	4	276	1	0	0	0	0	1	0	0	0	11464	855	30	2	707	2	PALM2-AKAP2	9	112898501	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	879771	112898501	28314930	961	50850											
SVEP1	79987	broad.mit.edu	37	chr9	113196736	113196736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttggaacctggctttaaatCttcagatgcagttctcagat	10	15	8	8	0	3	2	2	0	2	2	4	3	3	3	1	2	2	3	1	2	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:113196736C>T	uc010mtz.2	-	30	5276	c.4939G>A	c.(4939-4941)GAT>AAT	p.D1647N		NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1647	Sushi 5.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GGCTTTAAATCTTCAGATGCA	0.517													15	19					0	0	0	0	T	113196736	T	T	113196736	3	4	276	1	0	0	0	0	1	0	0	0	15486	913	32	2	5852	2	SVEP1	9	113196736	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	298235	113196736	28016695	962	50851											
OR2K2	26248	broad.mit.edu	37	chr9	114090371	114090371	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcatatgccatcacggccaGgagcacacactctgtggagc	10	7	11	13	1	3	0	2	0	1	0	3	2	3	2	2	3	3	1	2	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:114090371G>A	uc011lwp.1	-	1	343	c.343C>T	c.(343-345)CTG>TTG	p.L115L		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	144	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCACGGCCAGGAGCACACAC	0.517													13	37					0	0	0	0	A	114090371	A	A	114090371	2	1	276	1	0	0	0	0	0	0	0	1	11059	991	35	4		4	OR2K2	9	114090371	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	893635	114090371	27123060	963	50852											
C9orf84	158401	broad.mit.edu	37	chr9	114500596	114500596	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcgtaggcaaaaatatctCaattttagtgtcattagaag	14	15	7	5	1	2	1	2	0	1	1	4	1	2	1	0	1	0	2	0	1	8	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:114500596C>T	uc004bfr.2	-	10	1324	c.1189G>A	c.(1189-1191)GAG>AAG	p.E397K	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfs.1_Missense_Mutation_p.E461K|C9orf84_uc004bfq.2_Missense_Mutation_p.E358K|C9orf84_uc010mug.2_Missense_Mutation_p.E343K	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	397										ovary(2)	2						AAAAATATCTCAATTTTAGTG	0.289													11	61					0	0	0	0	T	114500596	T	T	114500596	3	4	276	1	0	0	0	0	1	0	0	0	2512	835	29	2	3213	2	C9orf84	9	114500596	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	410225	114500596	26712835	964	50853											
RGS3	5998	broad.mit.edu	37	chr9	116224447	116224447	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actcaaacttctccagccagGaagaggatcacgcatgccaa	14	6	8	13	1	3	1	2	0	1	1	4	3	3	3	3	2	3	1	3	2	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:116224447G>A	uc004bhq.2	+	4	590	c.381G>A	c.(379-381)AGG>AGA	p.R127R	RGS3_uc004bhr.2_5'Flank|RGS3_uc004bhs.2_5'Flank	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	127					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						CTCCAGCCAGGAAGAGGATCA	0.537													9	74					0	0	0	0	A	116224447	A	A	116224447	2	1	276	1	0	0	0	0	0	0	0	1	13371	1165	41	2		2	RGS3	9	116224447	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1723851	116224447	24988984	965	50854											
COL27A1	85301	broad.mit.edu	37	chr9	117014918	117014918	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caggcgtgcctggacccaagGggtcgatggtaaggagtaag	10	6	17	8	2	0	0	0	0	0	0	1	3	0	2	2	6	1	2	2	6	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:117014918G>A	uc011lxl.1	+	26	3079	c.3079G>A	c.(3079-3081)GGG>AGG	p.G1027R	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1027	Pro-rich.|Collagen-like 7.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						TGGACCCAAGGGGTCGATGGT	0.592													22	117					0	0	0	0	A	117014918	A	A	117014918	3	1	276	1	0	0	0	0	1	0	0	0	3700	1232	43	4	3181	4	COL27A1	9	117014918	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	790471	117014918	24198513	966	50855											
AKNA	80709	broad.mit.edu	37	chr9	117130730	117130730	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggactcacctgaggccgcaGaggcctgggggtcctcggcc	5	5	16	15	3	1	2	1	1	0	1	3	3	2	3	5	6	0	1	5	6	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:117130730G>A	uc004biq.3	-	4	1697	c.1562C>T	c.(1561-1563)TCT>TTT	p.S521F	AKNA_uc004bio.3_5'UTR|AKNA_uc004bip.3_Missense_Mutation_p.S440F|AKNA_uc004bir.3_Missense_Mutation_p.S521F|AKNA_uc004bis.3_Missense_Mutation_p.S521F|AKNA_uc010mve.2_Missense_Mutation_p.S402F|AKNA_uc004biu.1_Missense_Mutation_p.S262F|AKNA_uc004biv.1_Missense_Mutation_p.S521F	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						TGAGGCCGCAGAGGCCTGGGG	0.667													13	60					0	0	0	0	A	117130730	A	A	117130730	3	1	276	1	0	0	0	0	1	0	0	0	463	942	33	2	2829	2	AKNA	9	117130730	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	115812	117130730	24082701	967	50856											
TRIM32	22954	broad.mit.edu	37	chr9	119461243	119461243	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggctttttgaaggaaatcCgccgcagccccagtggcatt	10	9	11	11	2	0	1	0	1	0	0	1	2	1	2	4	3	1	3	4	3	3	3	rs3747835	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:119461243C>T	uc004bjx.2	+	2	1380	c.1222C>T	c.(1222-1224)CGC>TGC	p.R408C	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Missense_Mutation_p.R408C	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	408					fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						GAAGGAAATCCGCCGCAGCCC	0.512									Bardet-Biedl_syndrome				26	159					0	0	0	0	T	119461243	T	T	119461243	3	4	276	1	0	0	0	0	1	0	0	0	16573	652	23	1	1224	1	TRIM32	9	119461243	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2330513	119461243	21752188	968	50857											
TLR4	7099	broad.mit.edu	37	chr9	120475272	120475272	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgaccattgaagaattccGattagcatacttagactact	13	14	6	8	1	0	4	0	2	0	2	1	5	1	4	2	0	3	1	2	0	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:120475272G>A	uc004bjz.2	+	3	1157	c.866G>A	c.(865-867)CGA>CAA	p.R289Q	TLR4_uc004bka.2_Missense_Mutation_p.R249Q|TLR4_uc004bkb.2_Missense_Mutation_p.R89Q	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	289	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						GAAGAATTCCGATTAGCATAC	0.363													24	115					0	0	0	0	A	120475272	A	A	120475272	3	1	276	1	0	0	0	0	1	0	0	0	16019	1058	37	1	876	1	TLR4	9	120475272	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1014029	120475272	20738159	969	50858											
TLR4	7099	broad.mit.edu	37	chr9	120476800	120476800	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacacttacctggagtgggaGgacagtgtcctggggcggca	9	7	16	9	1	0	0	0	0	0	0	1	3	1	3	2	6	2	1	2	6	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:120476800G>A	uc004bjz.2	+	3	2685	c.2394G>A	c.(2392-2394)GAG>GAA	p.E798E	TLR4_uc004bka.2_Silent_p.E758E|TLR4_uc004bkb.2_Silent_p.E598E	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	798	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TGGAGTGGGAGGACAGTGTCC	0.542													38	75					0	0	0	0	A	120476800	A	A	120476800	2	1	276	1	0	0	0	0	0	0	0	1	16019	991	35	4		4	TLR4	9	120476800	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1528	120476800	20736631	970	50859											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123313139	123313139	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcctcaaggaaatagatgcgGagctttaggttaaagttttc	12	13	10	6	1	1	1	1	0	0	1	3	3	2	3	1	3	2	3	1	3	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:123313139G>A	uc004bkf.2	-	4	418	c.237C>T	c.(235-237)CTC>CTT	p.L79L	CDK5RAP2_uc004bkg.2_Silent_p.L79L|CDK5RAP2_uc011lxw.1_5'UTR|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_5'UTR|CDK5RAP2_uc011lya.1_5'UTR|CDK5RAP2_uc004bkh.1_Silent_p.L79L	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	79					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						AATAGATGCGGAGCTTTAGGT	0.393													17	129					0	0	0	0	A	123313139	A	A	123313139	2	1	276	1	0	0	0	0	0	0	0	1	3161	1161	41	2		2	CDK5RAP2	9	123313139	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2836339	123313139	17900292	971	50860											
C5	727	broad.mit.edu	37	chr9	123737102	123737102	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgtctgtcattttataattAtgtaaggcacctttatgctt	9	20	6	6	0	2	0	1	0	1	0	2	0	2	0	1	1	1	3	1	1	5	9			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:123737102A>G	uc004bkv.2	-	30	4002	c.3972T>C	c.(3970-3972)CAT>CAC	p.H1324H		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1324					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TTTTATAATTATGTAAGGCAC	0.388													19	128					0	0	0	0	G	123737102	G	G	123737102	2	3	276	1	0	0	0	0	0	0	0	1	2290	446	16	5		5	C5	9	123737102	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	423963	123737102	17476329	972	50861											
C5	727	broad.mit.edu	37	chr9	123744130	123744130	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actcttacttaccaccagggGgcatatatcgaaagcctttc	11	11	7	12	1	1	0	0	0	1	0	3	1	1	0	3	2	3	1	3	2	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:123744130G>A	uc004bkv.2	-	27	3508	c.3478C>T	c.(3478-3480)CCC>TCC	p.P1160S		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1160					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	ACCACCAGGGGGCATATATCG	0.413													6	33					0	0	0	0	A	123744130	A	A	123744130	3	1	276	1	0	0	0	0	1	0	0	0	2290	1232	43	4	1612	4	C5	9	123744130	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7028	123744130	17469301	973	50862											
CEP110	11064	broad.mit.edu	37	chr9	123880719	123880719	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaagctctggatctagaactGcagatggaaaagcaaaagca	17	6	11	7	0	2	2	0	0	2	2	2	5	2	4	0	2	5	4	0	2	7	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:123880719G>C	uc004bkx.1	+	10	1582	c.1551G>C	c.(1549-1551)CTG>CTC	p.L517L	CEP110_uc004bky.1_Silent_p.L121L	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	517	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						ATCTAGAACTGCAGATGGAAA	0.418													28	125					0	0	0	0	C	123880719	C	C	123880719	2	2	276	1	0	0	0	0	0	0	0	1	3260	1306	46	4		4	CEP110	9	123880719	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	136589	123880719	17332712	974	50863											
MRRF	92399	broad.mit.edu	37	chr9	125042818	125042818	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgaatgaagaaatgaagtCtgtgatagaagctctcaagg	15	9	13	4	0	2	6	1	4	2	2	3	6	2	6	0	2	1	1	0	2	7	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:125042818C>T	uc004bmb.2	+	3	396	c.281C>T	c.(280-282)TCT>TTT	p.S94F	MRRF_uc004bmc.2_Missense_Mutation_p.S94F|MRRF_uc011lyq.1_Missense_Mutation_p.S115F|MRRF_uc010mvz.1_RNA|MRRF_uc010mwa.2_Missense_Mutation_p.S94F|MRRF_uc011lyr.1_Intron|MRRF_uc004bmd.2_Missense_Mutation_p.S94F|MRRF_uc004bme.2_RNA	NM_138777	NP_620132	Q96E11	RRFM_HUMAN	mitochondrial ribosome recycling factor isoform	94					ribosome disassembly|translation	mitochondrion	sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						GAAATGAAGTCTGTGATAGAA	0.388													29	45					0	0	0	0	T	125042818	T	T	125042818	3	4	276	1	0	0	0	0	1	0	0	0	9903	913	32	2	287	2	MRRF	9	125042818	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1162099	125042818	16170613	975	50864											
OR1L4	254973	broad.mit.edu	37	chr9	125487082	125487082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccatgtactcagtgatgaagGgccgggtagccacagttatg	10	9	13	9	1	1	2	1	2	0	0	1	2	1	2	3	2	2	3	3	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:125487082G>A	uc004bmu.1	+	1	814	c.814G>A	c.(814-816)GGC>AGC	p.G272S		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGTGATGAAGGGCCGGGTAGC	0.468													28	52					0	0	0	0	A	125487082	A	A	125487082	3	1	276	1	0	0	0	0	1	0	0	0	11019	1232	43	4	816	4	OR1L4	9	125487082	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	444264	125487082	15726349	976	50865											
CRB2	286204	broad.mit.edu	37	chr9	126132586	126132586	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atccctatcttcgagtctggGgtccacagttacgtctgcca	7	12	9	13	2	3	0	0	0	3	0	6	1	5	0	3	2	2	1	3	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:126132586G>A	uc004bnx.1	+	7	1346	c.1254G>A	c.(1252-1254)GGG>GGA	p.G418G	CRB2_uc004bnw.1_Silent_p.G418G	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	418	Extracellular (Potential).|EGF-like 9.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						TCGAGTCTGGGGTCCACAGTT	0.622													7	30					0	0	0	0	A	126132586	A	A	126132586	2	1	276	1	0	0	0	0	0	0	0	1	3864	1219	43	4		4	CRB2	9	126132586	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	645504	126132586	15080845	977	50866											
MAPKAP1	79109	broad.mit.edu	37	chr9	128321983	128321983	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaccagggccaaagtactGaagccaaacttatgaatggg	15	7	10	9	0	1	2	1	2	0	0	1	2	1	2	3	2	4	1	3	2	7	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:128321983G>A	uc004bpv.2	-	6	1110	c.777C>T	c.(775-777)TTC>TTT	p.F259F	MAPKAP1_uc011lzt.1_Silent_p.F62F|MAPKAP1_uc010mwz.2_RNA|MAPKAP1_uc011lzu.1_Silent_p.F62F|MAPKAP1_uc011lzv.1_Intron|MAPKAP1_uc004bpw.2_Silent_p.F67F|MAPKAP1_uc004bpx.2_Silent_p.F67F|MAPKAP1_uc004bpy.2_Silent_p.F259F|MAPKAP1_uc004bpz.2_Silent_p.F259F|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc010mxb.1_Silent_p.F62F|MAPKAP1_uc004bqa.2_Silent_p.F259F|MAPKAP1_uc010mxc.1_Silent_p.F131F	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	259					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						CCAAAGTACTGAAGCCAAACT	0.483													7	47					0	0	0	0	A	128321983	A	A	128321983	2	1	276	1	0	0	0	0	0	0	0	1	9341	1281	45	2		2	MAPKAP1	9	128321983	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2189397	128321983	12891448	978	50867											
RALGPS1	9649	broad.mit.edu	37	chr9	129931022	129931022	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtacgctacattgaagagctCcagaagtttgtggaagacga	13	9	12	7	2	0	4	0	1	0	3	1	6	1	5	1	1	3	4	1	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:129931022C>T	uc004bqo.1	+	10	1080	c.813C>T	c.(811-813)CTC>CTT	p.L271L	RALGPS1_uc011mab.1_Silent_p.L271L|RALGPS1_uc011mac.1_Silent_p.L271L|RALGPS1_uc004bqq.3_Silent_p.L271L	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	271	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						TTGAAGAGCTCCAGAAGTTTG	0.517													19	136					0	0	0	0	T	129931022	T	T	129931022	2	4	276	1	0	0	0	0	0	0	0	1	13082	842	30	2		2	RALGPS1	9	129931022	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1609039	129931022	11282409	979	50868											
PTRH1	138428	broad.mit.edu	37	chr9	130476448	130476448	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaggtcggtggctcgatcCagcaacagaggcagcagctc	10	6	13	12	2	1	1	1	0	0	1	5	2	2	1	1	4	4	5	1	4	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:130476448C>T	uc004bro.2	-	5	594	c.576G>A	c.(574-576)CTG>CTA	p.L192L	PTRH1_uc004brm.2_Intron|PTRH1_uc010mxm.2_Nonsense_Mutation_p.W190*|PTRH1_uc011mah.1_Silent_p.L205L|TTC16_uc004brq.1_5'Flank|TTC16_uc011mai.1_5'Flank|TTC16_uc004brr.1_5'Flank	NM_001002913	NP_001002913	Q86Y79	PTH_HUMAN	peptidyl-tRNA hydrolase 1 homolog	192					translation		aminoacyl-tRNA hydrolase activity|protein binding				0						TGGCTCGATCCAGCAACAGAG	0.667													5	37					0	0	0	0	T	130476448	T	T	130476448	2	4	276	1	0	0	0	0	0	0	0	1	12881	581	21	4		4	PTRH1	9	130476448	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	545426	130476448	10736983	980	50869											
ENG	2022	broad.mit.edu	37	chr9	130581106	130581106	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatgttgaggcagtgcacCtttttctgggggaggacggg	6	11	16	8	1	1	1	0	1	1	0	2	3	2	3	2	5	1	3	2	5	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:130581106C>T	uc004bsj.3	-	11	1730	c.1317G>A	c.(1315-1317)AAG>AAA	p.K439K	ENG_uc011mam.1_Silent_p.K250K|ENG_uc004bsk.3_Silent_p.K439K|uc004bsl.1_Intron	NM_001114753	NP_001108225	P17813	EGLN_HUMAN	endoglin isoform 1 precursor	439	Ser/Thr-rich.|Extracellular (Potential).				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding				0						GGCAGTGCACCTTTTTCTGGG	0.637									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				77	158					0	0	0	0	T	130581106	T	T	130581106	2	4	276	1	0	0	0	0	0	0	0	1	5141	680	24	4		4	ENG	9	130581106	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	104658	130581106	10632325	981	50870											
ASS1	445	broad.mit.edu	37	chr9	133346897	133346897	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggctggaatcctggagaacCccaaggtaatcccccaaacc	13	5	9	14	0	0	1	0	0	0	1	2	3	2	2	6	4	2	2	6	4	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:133346897C>T	uc004bzm.2	+	9	948	c.592C>T	c.(592-594)CCC>TCC	p.P198S	ASS1_uc004bzn.2_Missense_Mutation_p.P198S|ASS1_uc010mza.2_Missense_Mutation_p.P274S|ASS1_uc004bzo.2_Missense_Mutation_p.P179S|ASS1_uc010mzb.2_Missense_Mutation_p.P236S|ASS1_uc004bzp.2_Missense_Mutation_p.P198S|ASS1_uc010mzc.2_Missense_Mutation_p.P198S	NM_000050	NP_000041	P00966	ASSY_HUMAN	argininosuccinate synthetase 1	198					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	CCTGGAGAACCCCAAGGTAAT	0.562													19	35					0	0	0	0	T	133346897	T	T	133346897	3	4	276	1	0	0	0	0	1	0	0	0	1063	623	22	4	618	4	ASS1	9	133346897	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2765791	133346897	7866534	982	50871											
FUBP3	8939	broad.mit.edu	37	chr9	133506164	133506164	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggccaggcagctcatagatGagaaagttggcgtacgtaca	12	8	13	8	2	1	2	1	1	0	2	1	3	1	2	1	3	3	5	1	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:133506164G>A	uc004bzr.1	+	13	1375	c.1267G>A	c.(1267-1269)GAG>AAG	p.E423K	FUBP3_uc004bzs.1_Missense_Mutation_p.E336K	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	423					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		GCTCATAGATGAGAAAGTTGG	0.567													11	25					0	0	0	0	A	133506164	A	A	133506164	3	1	276	1	0	0	0	0	1	0	0	0	6127	1291	45	2	1317	2	FUBP3	9	133506164	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	159267	133506164	7707267	983	50872											
LAMC3	10319	broad.mit.edu	37	chr9	133928244	133928244	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cttctctcgccagcctgcagGagacctccgaggacgtggcc	6	7	12	16	3	1	1	0	0	1	1	4	4	2	2	5	3	2	1	5	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:133928244G>A	uc004caa.1	+	11	1929	c.1831G>A	c.(1831-1833)GAG>AAG	p.E611K		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	611	Laminin IV type A.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CAGCCTGCAGGAGACCTCCGA	0.687											OREG0019556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	44					0	0	0	0	A	133928244	A	A	133928244	3	1	276	1	0	0	0	0	1	0	0	0	8656	1175	41	2	1873	2	LAMC3	9	133928244	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	422080	133928244	7285187	984	50873											
C9orf98	158067	broad.mit.edu	37	chr9	135698629	135698629	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgggccaggagggcggcCtgcagacttttcccactgcc	5	9	13	14	1	1	1	0	0	1	1	2	2	2	2	4	4	2	1	4	4	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:135698629C>T	uc004cbu.1	-	9	1408	c.852G>A	c.(850-852)CAG>CAA	p.Q284Q	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_Silent_p.Q80Q	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	284	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		GGAGGGCGGCCTGCAGACTTT	0.617													28	174					0	0	0	0	T	135698629	T	T	135698629	2	4	276	1	0	0	0	0	0	0	0	1	2521	680	24	4		4	C9orf98	9	135698629	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1770385	135698629	5514802	985	50874											
TSC1	7248	broad.mit.edu	37	chr9	135781032	135781032	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctgtccagcacttccattgGggaggtagagggcacaccat	9	9	12	11	0	1	1	0	0	1	1	3	2	3	2	3	4	1	3	3	4	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:135781032G>A	uc004cca.2	-	15	2167	c.1933C>T	c.(1933-1935)CCA>TCA	p.P645S	TSC1_uc004ccb.3_Missense_Mutation_p.P644S|TSC1_uc011mcq.1_Missense_Mutation_p.P594S|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	645					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		ACTTCCATTGGGGAGGTAGAG	0.498			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				13	106					0	0	0	0	A	135781032	A	A	135781032	3	1	276	1	0	0	0	0	1	0	0	0	16672	1232	43	4	1597	4	TSC1	9	135781032	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	82403	135781032	5432399	986	50875											
GTF3C5	9328	broad.mit.edu	37	chr9	135917600	135917600	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatcaggaagagaacgaggCggcagaaaggggtgctgggc	12	3	19	7	2	1	2	1	0	0	2	1	5	1	3	0	6	2	3	0	6	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:135917600C>T	uc004cci.3	+	2	617	c.280C>T	c.(280-282)CGG>TGG	p.R94W	GTF3C5_uc010mzz.2_Intron|GTF3C5_uc004ccj.3_Missense_Mutation_p.R94W	NM_012087	NP_036219	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5	94						transcription factor TFIIIC complex	DNA binding|protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		GAGAACGAGGCGGCAGAAAGG	0.572													15	131					0	0	0	0	T	135917600	T	T	135917600	3	4	276	1	0	0	0	0	1	0	0	0	6915	759	27	1	286	1	GTF3C5	9	135917600	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	136568	135917600	5295831	987	50876											
GBGT1	26301	broad.mit.edu	37	chr9	136029195	136029195	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccctagtaaactcatatacCctggccacctgccccccgaa	10	7	5	19	1	1	0	1	0	0	0	1	1	1	0	8	1	3	1	8	1	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:136029195C>T	uc004ccw.2	-	7	1094	c.813G>A	c.(811-813)AGG>AGA	p.R271R	RALGDS_uc011mcw.1_Intron|GBGT1_uc004ccx.2_Silent_p.R224R|GBGT1_uc010nab.2_3'UTR|GBGT1_uc011mcx.1_Silent_p.R254R|GBGT1_uc010nac.1_Silent_p.R135R|GBGT1_uc004ccy.1_3'UTR	NM_021996	NP_068836	Q8N5D6	GBGT1_HUMAN	globoside	271	Lumenal (Potential).				carbohydrate metabolic process|glycolipid biosynthetic process	Golgi membrane|integral to membrane	metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;3.49e-06)|Epithelial(140;2.59e-05)		ACTCATATACCCTGGCCACCT	0.592													10	96					0	0	0	0	T	136029195	T	T	136029195	2	4	276	1	0	0	0	0	0	0	0	1	6307	622	22	4		4	GBGT1	9	136029195	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	111595	136029195	5184236	988	50877											
ADAMTS13	11093	broad.mit.edu	37	chr9	136314957	136314957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgggagaggggtcgtgcGgaggatcctgtattgtgccc	5	10	18	8	2	0	1	0	0	0	1	2	4	1	3	2	5	2	1	2	5	1	2	rs139951127		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:136314957G>A	uc004cdv.3	+	23	3359	c.2915G>A	c.(2914-2916)CGG>CAG	p.R972Q	ADAMTS13_uc004cdp.3_Missense_Mutation_p.R199Q|ADAMTS13_uc004cdt.1_Missense_Mutation_p.R972Q|ADAMTS13_uc004cdu.1_Missense_Mutation_p.R941Q|ADAMTS13_uc004cdw.3_Missense_Mutation_p.R972Q|ADAMTS13_uc004cdx.3_Missense_Mutation_p.R941Q|ADAMTS13_uc004cdy.1_RNA|ADAMTS13_uc004cdz.3_Missense_Mutation_p.R642Q	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	972	TSP type-1 6.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GGGGTCGTGCGGAGGATCCTG	0.667													27	95					0	0	0	0	A	136314957	A	A	136314957	3	1	276	1	0	0	0	0	1	0	0	0	258	1116	39	1	3005	1	ADAMTS13	9	136314957	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	285762	136314957	4898474	989	50878											
COL5A1	1289	broad.mit.edu	37	chr9	137623462	137623462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	accccaccagctccccgtcgGagatcgggccgggaatgccg	7	4	13	17	5	0	1	0	0	0	1	3	3	1	2	7	3	2	1	7	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:137623462G>A	uc004cfe.2	+	8	1667	c.1285G>A	c.(1285-1287)GAG>AAG	p.E429K		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	429	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CTCCCCGTCGGAGATCGGGCC	0.557													20	150					0	0	0	0	A	137623462	A	A	137623462	3	1	276	1	0	0	0	0	1	0	0	0	3711	1175	41	2	1315	2	COL5A1	9	137623462	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1308505	137623462	3589969	990	50879											
COL5A1	1289	broad.mit.edu	37	chr9	137704485	137704485	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctggcccccgaggaccctCcggagctccaggtgctgatg	5	6	13	17	2	0	1	0	1	0	0	2	4	2	3	6	4	2	2	6	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:137704485C>T	uc004cfe.2	+	48	4161	c.3779C>T	c.(3778-3780)TCC>TTC	p.S1260F		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1260	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CGAGGACCCTCCGGAGCTCCA	0.632													3	15					0	0	0	0	T	137704485	T	T	137704485	3	4	276	1	0	0	0	0	1	0	0	0	3711	855	30	2	3969	2	COL5A1	9	137704485	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	81023	137704485	3508946	991	50880											
SEC16A	9919	broad.mit.edu	37	chr9	139338337	139338337	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggagggccccctgcagcagGgaggtcgccaggagcctgag	7	3	19	12	1	0	1	0	1	0	0	1	4	0	4	4	5	3	2	4	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:139338337G>A	uc004chx.2	-	31	7252	c.6943C>T	c.(6943-6945)CCT>TCT	p.P2315S	SEC16A_uc004chp.2_RNA|SEC16A_uc004chq.2_Missense_Mutation_p.P158S|SEC16A_uc011mea.1_Missense_Mutation_p.P155S|SEC16A_uc004chr.2_Missense_Mutation_p.P343S|SEC16A_uc004chs.2_Missense_Mutation_p.P155S|SEC16A_uc004cht.2_Missense_Mutation_p.P365S|SEC16A_uc004chu.2_Missense_Mutation_p.P522S|SEC16A_uc004chv.3_Missense_Mutation_p.P1685S|SEC16A_uc004chw.2_Missense_Mutation_p.P2290S|SEC16A_uc010nbn.2_Missense_Mutation_p.P2292S	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	2137	Required for interaction with SEC23A.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CCTGCAGCAGGGAGGTCGCCA	0.612													4	44					0	0	0	0	A	139338337	A	A	139338337	3	1	276	1	0	0	0	0	1	0	0	0	14051	1232	43	4	138	4	SEC16A	9	139338337	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1633852	139338337	1875094	992	50881											
ENTPD2	954	broad.mit.edu	37	chr9	139944949	139944949	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acatccccgagcagcacttgGgtggaaaagcccctcggcca	10	5	11	15	2	0	0	0	0	0	0	2	2	1	1	5	3	3	2	5	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:139944949G>A	uc004ckw.1	-	6	872	c.816C>T	c.(814-816)ACC>ACT	p.T272T	ENTPD2_uc004ckv.1_5'Flank|ENTPD2_uc004ckx.1_Silent_p.T272T	NM_203468	NP_982293	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	272	Extracellular (Potential).					integral to membrane	ATP binding				0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCAGCACTTGGGTGGAAAAGC	0.647											OREG0019627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	30					0	0	0	0	A	139944949	A	A	139944949	2	1	276	1	0	0	0	0	0	0	0	1	5163	1219	43	4		4	ENTPD2	9	139944949	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	606612	139944949	1268482	993	50882											
ANAPC2	29882	broad.mit.edu	37	chr9	140078134	140078134	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cacacagcacctggatgcagGagccgagtctccagggcagc	10	4	13	14	1	1	0	0	0	1	0	2	3	1	2	3	3	4	3	3	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:140078134G>A	uc004clr.1	-	5	1231	c.1158C>T	c.(1156-1158)CTC>CTT	p.L386L	ANAPC2_uc004clq.1_Silent_p.L242L	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	386					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		CTGGATGCAGGAGCCGAGTCT	0.657													3	19					0	0	0	0	A	140078134	A	A	140078134	2	1	276	1	0	0	0	0	0	0	0	1	603	1161	41	2		2	ANAPC2	9	140078134	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	133185	140078134	1135297	994	50883											
FAM166A	401565	broad.mit.edu	37	chr9	140139886	140139886	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acggagggtgcggggtgtcgGgcgtgaagcctgcaggcagc	6	5	21	9	4	0	1	0	1	0	0	1	2	0	2	1	6	4	2	1	6	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:140139886G>A	uc004cmi.1	-	3	450	c.395C>T	c.(394-396)CCC>CTC	p.P132L		NM_001001710	NP_001001710	Q6J272	F166A_HUMAN	hypothetical protein LOC401565	132										ovary(1)	1						CGGGGTGTCGGGCGTGAAGCC	0.642													18	118					0	0	0	0	A	140139886	A	A	140139886	3	1	276	1	0	0	0	0	1	0	0	0	5509	1232	43	4	578	4	FAM166A	9	140139886	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	61752	140139886	1073545	995	50884											
NOXA1	10811	broad.mit.edu	37	chr9	140323432	140323432	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccaagtggccggaggggtcCctgaatggcctggactcagc	7	7	15	12	1	1	1	1	1	0	0	3	3	3	3	4	6	1	0	4	6	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:140323432C>T	uc004cmv.2	+	4	603	c.468C>T	c.(466-468)TCC>TCT	p.S156S	C9orf167_uc011mew.1_Intron|NOXA1_uc004cmu.2_Silent_p.S156S|NOXA1_uc010nch.2_Silent_p.S156S	NM_006647	NP_006638	Q86UR1	NOXA1_HUMAN	NADPH oxidase activator 1	156	Mediates interaction with RAC1.				regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|superoxide metabolic process	cytoplasm|NADPH oxidase complex	Rac GTPase binding|superoxide-generating NADPH oxidase activator activity				0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000238)|Epithelial(140;0.000982)		CGGAGGGGTCCCTGAATGGCC	0.622													3	11					0	0	0	0	T	140323432	T	T	140323432	2	4	276	1	0	0	0	0	0	0	0	1	10614	610	22	4		4	NOXA1	9	140323432	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	183546	140323432	889999	996	50885											
PNPLA7	375775	broad.mit.edu	37	chr9	140358627	140358627	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtgatgtcggtggtgatggcGaaataaggaatccacaggtc	11	9	15	6	2	0	2	0	2	0	0	3	4	1	3	1	5	0	0	1	5	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:140358627G>A	uc004cnf.2	-	27	3439	c.3102C>T	c.(3100-3102)TTC>TTT	p.F1034F	C9orf167_uc011mew.1_Intron|PNPLA7_uc004cnd.1_Silent_p.F300F|PNPLA7_uc004cne.1_Silent_p.F300F|PNPLA7_uc011mfa.1_Silent_p.F442F|PNPLA7_uc010ncj.1_Silent_p.F1059F	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1034	Patatin.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TGGTGATGGCGAAATAAGGAA	0.672													7	35					0	0	0	0	A	140358627	A	A	140358627	2	1	276	1	0	0	0	0	0	0	0	1	12225	1049	37	1		1	PNPLA7	9	140358627	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	35195	140358627	854804	997	50886											
PNPLA7	375775	broad.mit.edu	37	chr9	140389515	140389515	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgcgcttgatggacgtgagGgctcctgccggcagcttggc	4	9	16	12	3	0	2	0	2	0	0	1	3	1	3	2	4	3	4	2	4	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:140389515G>A	uc004cnf.2	-	18	2359	c.2022C>T	c.(2020-2022)GCC>GCT	p.A674A	C9orf167_uc011mew.1_Intron|PNPLA7_uc011mfa.1_Intron|PNPLA7_uc010ncj.1_Silent_p.A699A	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	674	cNMP 3.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TGGACGTGAGGGCTCCTGCCG	0.597													13	75					0	0	0	0	A	140389515	A	A	140389515	2	1	276	1	0	0	0	0	0	0	0	1	12225	1219	43	4		4	PNPLA7	9	140389515	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	30888	140389515	823916	998	50887											
EHMT1	79813	broad.mit.edu	37	chr9	140611609	140611609	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtccacagggcacgcaagaCcatgccgaagtccgtcgtgg	9	5	14	13	4	0	1	0	0	0	1	3	2	2	1	4	3	1	2	4	3	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr9:140611609C>T	uc011mfc.1	+	3	654	c.617C>T	c.(616-618)ACC>ATC	p.T206I	EHMT1_uc004coa.2_Missense_Mutation_p.T206I|EHMT1_uc004cob.1_Missense_Mutation_p.T175I	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	206					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GCACGCAAGACCATGCCGAAG	0.572													13	57					0	0	0	0	T	140611609	T	T	140611609	3	4	276	1	0	0	0	0	1	0	0	0	5005	507	18	4	627	4	EHMT1	9	140611609	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	222094	140611609	601822	999	50888											
NET1	10276	broad.mit.edu	37	chr10	5498571	5498571	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctaaaaatatctttagaattCgcttccatgacccctctcca	12	13	3	13	1	2	2	0	1	2	1	5	2	3	2	4	0	0	1	4	0	6	6	rs150542987		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:5498571C>T	uc001iia.2	+	12	1543	c.1405C>T	c.(1405-1407)CGC>TGC	p.R469C	NET1_uc010qar.1_Missense_Mutation_p.R288C|NET1_uc001iib.2_Missense_Mutation_p.R415C|NET1_uc010qas.1_Missense_Mutation_p.R288C	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	469	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						CTTTAGAATTCGCTTCCATGA	0.403													15	75					0	0	0	0	T	5498571	T	T	5498571	3	4	276	1	0	0	0	0	1	0	0	0	10392	884	31	1	1548	1	NET1	10	5498571	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08		5498571	130036176	1000	50889											
FBXO18	84893	broad.mit.edu	37	chr10	5966446	5966446	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtgcaaaggatagaaaaatgCcatatagaagatttggactt	17	10	10	4	0	0	3	0	0	0	3	0	5	0	5	1	2	2	1	1	2	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:5966446C>T	uc001iis.2	+	17	2666	c.2571C>T	c.(2569-2571)TGC>TGT	p.C857C	FBXO18_uc001iir.2_Silent_p.C783C|FBXO18_uc009xig.2_Silent_p.C783C|FBXO18_uc001iit.2_Silent_p.C908C	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	857					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						TAGAAAAATGCCATATAGAAG	0.428													9	24					0	0	0	0	T	5966446	T	T	5966446	2	4	276	1	0	0	0	0	0	0	0	1	5763	747	26	4		4	FBXO18	10	5966446	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	467875	5966446	129568301	1001	50890											
PRKCQ	5588	broad.mit.edu	37	chr10	6540382	6540382	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caaactcgtggcagacagagCaaaatgtgggctgtgggaag	13	6	15	7	1	0	2	0	0	0	2	1	3	0	3	0	3	2	3	0	3	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:6540382C>A	uc001ijj.1	-	5	593	c.518G>T	c.(517-519)TGC>TTC	p.C173F	PRKCQ_uc009xim.1_Missense_Mutation_p.C173F|PRKCQ_uc001iji.1_Missense_Mutation_p.C206F|PRKCQ_uc009xin.1_Missense_Mutation_p.C137F|PRKCQ_uc010qax.1_Missense_Mutation_p.C48F	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	173	Phorbol-ester/DAG-type 1.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						GCAGACAGAGCAAAATGTGGG	0.527													23	83					3.28513e-13	3.37838e-13	1	0	A	6540382	A	A	6540382	3	1	276	1	0	0	0	0	1	0	0	0	12577	710	25	4	1658	4	PRKCQ	10	6540382	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	573936	6540382	128994365	1002	50891											
SFMBT2	57713	broad.mit.edu	37	chr10	7214518	7214518	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtttcttctgcacgaaaatgGatttccgtcgcttcctccgc	6	14	8	13	4	2	0	0	0	2	0	6	2	5	1	3	1	1	3	3	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:7214518G>A	uc009xio.1	-	18	2181	c.2090C>T	c.(2089-2091)TCC>TTC	p.S697F	SFMBT2_uc001ijn.1_Missense_Mutation_p.S697F|SFMBT2_uc010qay.1_Missense_Mutation_p.S532F	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	697					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						CACGAAAATGGATTTCCGTCG	0.602													10	49					0	0	0	0	A	7214518	A	A	7214518	3	1	276	1	0	0	0	0	1	0	0	0	14223	1174	41	2	610	2	SFMBT2	10	7214518	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	674136	7214518	128320229	1003	50892											
NUDT5	11164	broad.mit.edu	37	chr10	12219884	12219884	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaagtgttctctgcagcacgGggatgaccgcgacacctgtc	8	8	13	12	3	1	1	0	1	1	0	3	4	1	2	2	2	2	3	2	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:12219884G>A	uc001ilj.2	-	5	613	c.197C>T	c.(196-198)CCC>CTC	p.P66L	NUDT5_uc001ilk.2_Missense_Mutation_p.P66L	NM_014142	NP_054861	Q9UKK9	NUDT5_HUMAN	nudix-type motif 5	66	Nudix hydrolase.				D-ribose catabolic process|ribonucleoside diphosphate catabolic process	intracellular	ADP-ribose diphosphatase activity|magnesium ion binding			ovary(1)|pancreas(1)	2		Renal(717;0.228)				CTGCAGCACGGGGATGACCGC	0.502													7	38					0	0	0	0	A	12219884	A	A	12219884	3	1	276	1	0	0	0	0	1	0	0	0	10796	1232	43	4	486	4	NUDT5	10	12219884	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5005366	12219884	123314863	1004	50893											
CUBN	8029	broad.mit.edu	37	chr10	16948290	16948290	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggaaatggatgaatttccCtgatttggattgctgagagt	11	14	12	4	0	0	3	0	3	0	1	1	7	1	6	1	3	1	1	1	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:16948290C>T	uc001ioo.2	-	50	7876	c.7824G>A	c.(7822-7824)CAG>CAA	p.Q2608Q	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_5'UTR	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2608	CUB 19.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGAATTTCCCTGATTTGGAT	0.413													8	87					0	0	0	0	T	16948290	T	T	16948290	2	4	276	1	0	0	0	0	0	0	0	1	4068	680	24	4		4	CUBN	10	16948290	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4728406	16948290	118586457	1005	50894											
GPR158	57512	broad.mit.edu	37	chr10	25878064	25878064	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatcatctctgctatattcCatacaattaggcaagtgatc	12	14	5	10	0	3	1	2	1	1	0	6	1	4	1	1	1	2	2	1	1	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:25878064C>T	uc001isj.2	+	8	1942	c.1882C>T	c.(1882-1884)CAT>TAT	p.H628Y		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	628	Helical; Name=6; (Potential).			ELIISAIFHTI -> SWIVNSMNSHF (in Ref. 3).		integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TGCTATATTCCATACAATTAG	0.378													11	40					0	0	0	0	T	25878064	T	T	25878064	3	4	276	1	0	0	0	0	1	0	0	0	6701	594	21	4	1912	4	GPR158	10	25878064	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	8929774	25878064	109656683	1006	50895											
GAD2	2572	broad.mit.edu	37	chr10	26518694	26518694	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttcccaggctcattgccttCacgtctgaacatgtatgtgt	7	14	8	12	1	3	1	2	1	1	0	4	1	4	1	2	1	2	2	2	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:26518694C>T	uc001isp.2	+	7	1331	c.828C>T	c.(826-828)TTC>TTT	p.F276F	GAD2_uc001isq.2_Silent_p.F276F	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	276					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TCATTGCCTTCACGTCTGAAC	0.448													18	28					0	0	0	0	T	26518694	T	T	26518694	2	4	276	1	0	0	0	0	0	0	0	1	6214	825	29	2		2	GAD2	10	26518694	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	640630	26518694	109016053	1007	50896											
ANKRD26	22852	broad.mit.edu	37	chr10	27324456	27324456	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagaacactaagccgtccatTatactgggatattgtttgtg	11	13	9	8	1	0	1	0	0	0	1	1	2	1	2	2	1	3	1	2	1	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:27324456T>A	uc001ith.2	-	24	3092	c.2920A>T	c.(2920-2922)AAT>TAT	p.N974Y	ANKRD26_uc001itg.2_Missense_Mutation_p.N661Y|ANKRD26_uc009xku.1_Missense_Mutation_p.N975Y	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	974	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						AGCCGTCCATTATACTGGGAT	0.353													34	62					0	0	0	0	A	27324456	A	A	27324456	3	1	276	1	0	0	0	0	1	0	0	0	654	1754	61	5	2253	5	ANKRD26	10	27324456	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	805762	27324456	108210291	1008	50897											
PTCHD3	374308	broad.mit.edu	37	chr10	27687894	27687894	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagcataggcagactacttCtcttttaccatccaaggcca	11	10	6	14	0	1	1	0	0	1	1	3	1	2	1	4	2	3	2	4	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:27687894C>T	uc001itu.2	-	4	1751	c.1633G>A	c.(1633-1635)GAA>AAA	p.E545K		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	545					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CAGACTACTTCTCTTTTACCA	0.393													17	62					0	0	0	0	T	27687894	T	T	27687894	3	4	276	1	0	0	0	0	1	0	0	0	12796	922	32	2	674	2	PTCHD3	10	27687894	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	363438	27687894	107846853	1009	50898											
KIAA1462	57608	broad.mit.edu	37	chr10	30315322	30315322	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggtcagggtctgctctcCtaggcggggaggccagtttc	4	9	17	11	2	3	0	1	0	2	0	5	1	3	1	2	7	1	2	2	7	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:30315322C>T	uc001iux.2	-	2	3814	c.3755G>A	c.(3754-3756)AGG>AAG	p.R1252K	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.R1114K|KIAA1462_uc009xle.1_Missense_Mutation_p.R1252K	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1252										ovary(4)	4						GTCTGCTCTCCTAGGCGGGGA	0.522													14	53					0	0	0	0	T	30315322	T	T	30315322	3	4	276	1	0	0	0	0	1	0	0	0	8273	681	24	4	332	4	KIAA1462	10	30315322	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2627428	30315322	105219425	1010	50899											
ITGB1	3688	broad.mit.edu	37	chr10	33208967	33208967	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aattttaaagctgtcagaatCcttttttggacacttatttg	11	18	6	6	0	1	1	1	0	0	1	2	2	2	2	1	1	1	1	1	1	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:33208967C>T	uc001iws.3	-	11	1451	c.1315G>A	c.(1315-1317)GAT>AAT	p.D439N	ITGB1_uc001iwp.3_Missense_Mutation_p.D439N|ITGB1_uc001iwq.3_Missense_Mutation_p.D439N|ITGB1_uc001iwr.3_Missense_Mutation_p.D439N|ITGB1_uc001iwt.3_Missense_Mutation_p.D439N|ITGB1_uc001iwu.1_Missense_Mutation_p.D439N	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	439	Extracellular (Potential).				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				CTGTCAGAATCCTTTTTTGGA	0.348													62	112					0	0	0	0	T	33208967	T	T	33208967	3	4	276	1	0	0	0	0	1	0	0	0	7929	855	30	2	1343	2	ITGB1	10	33208967	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2893645	33208967	102325780	1011	50900											
ITGB1	3688	broad.mit.edu	37	chr10	33217084	33217084	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatctgttccaagactttttAcattctccaaatcgtctttc	9	17	4	11	1	3	1	0	0	3	1	7	2	4	1	2	0	1	1	2	0	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:33217084A>C	uc001iws.3	-	5	621	c.485T>G	c.(484-486)GTA>GGA	p.V162G	ITGB1_uc001iwp.3_Missense_Mutation_p.V162G|ITGB1_uc001iwq.3_Missense_Mutation_p.V162G|ITGB1_uc001iwr.3_Missense_Mutation_p.V162G|ITGB1_uc001iwt.3_Missense_Mutation_p.V162G|ITGB1_uc001iwu.1_Missense_Mutation_p.V162G	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	162	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				AAGACTTTTTACATTCTCCAA	0.338													26	79					0	0	0	0	C	33217084	C	C	33217084	3	2	276	1	0	0	0	0	1	0	0	0	7929	391	14	5	2197	5	ITGB1	10	33217084	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	8117	33217084	102317663	1012	50901											
ZNF239	8187	broad.mit.edu	37	chr10	44052301	44052301	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaactctggctaaatcccttCccacacttgccacagtgata	11	10	6	14	0	1	1	0	1	1	0	3	2	3	1	3	1	2	1	3	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:44052301C>T	uc001jaw.3	-	2	1880	c.1227G>A	c.(1225-1227)GGG>GGA	p.G409G	ZNF239_uc001jax.3_Silent_p.G409G|ZNF239_uc009xmj.2_Silent_p.G409G|ZNF239_uc009xmk.2_Silent_p.G409G	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	409	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						TAAATCCCTTCCCACACTTGC	0.522													6	39					0	0	0	0	T	44052301	T	T	44052301	2	4	276	1	0	0	0	0	0	0	0	1	17858	842	30	2		2	ZNF239	10	44052301	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	10835217	44052301	91482446	1013	50902											
RBP3	5949	broad.mit.edu	37	chr10	48390169	48390169	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcgatgtcctcggccacgcCcctggtctggctgctggtga	3	9	14	15	4	1	1	0	1	1	0	3	2	2	1	4	4	1	2	4	4	0	0	rs139362090		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:48390169C>T	uc001jez.2	-	1	823	c.709G>A	c.(709-711)GGC>AGC	p.G237S		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	237	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	TCGGCCACGCCCCTGGTCTGG	0.657													10	25					0	0	0	0	T	48390169	T	T	48390169	3	4	276	1	0	0	0	0	1	0	0	0	13222	623	22	4	3050	4	RBP3	10	48390169	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4337868	48390169	87144578	1014	50903											
GDF10	2662	broad.mit.edu	37	chr10	48428967	48428967	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcgcgcggcggcctctcatCcagccccggcagctcgttgt	3	7	14	17	6	1	0	1	0	1	0	4	0	2	0	4	4	2	3	4	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:48428967C>T	uc001jfb.2	-	2	1375	c.919G>A	c.(919-921)GAT>AAT	p.D307N	GDF10_uc009xnp.2_Missense_Mutation_p.D306N|GDF10_uc009xnq.1_Missense_Mutation_p.D307N	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	307					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						GGCCTCTCATCCAGCCCCGGC	0.746													3	13					0	0	0	0	T	48428967	T	T	48428967	3	4	276	1	0	0	0	0	1	0	0	0	6348	855	30	2	525	2	GDF10	10	48428967	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	38798	48428967	87105780	1015	50904											
ARID5B	84159	broad.mit.edu	37	chr10	63851606	63851606	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctccaagcatcaccttaaccCccttgctgactcctacgtcc	8	10	4	19	1	1	1	1	1	0	0	4	1	4	1	6	0	4	2	6	0	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:63851606C>T	uc001jlt.1	+	10	2410	c.2384C>T	c.(2383-2385)CCC>CTC	p.P795L		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	795					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CACCTTAACCCCCTTGCTGAC	0.507													75	60					0	0	0	0	T	63851606	T	T	63851606	3	4	276	1	0	0	0	0	1	0	0	0	922	623	22	4	2422	4	ARID5B	10	63851606	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	15422639	63851606	71683141	1016	50905											
JMJD1C	221037	broad.mit.edu	37	chr10	64974629	64974629	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttcctgtatttgatcccagGgaggctggctattttttagg	6	16	11	8	0	0	1	0	1	0	0	2	2	2	2	2	4	0	3	2	4	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:64974629G>A	uc001jmn.2	-	8	1598	c.1298C>T	c.(1297-1299)CCC>CTC	p.P433L	JMJD1C_uc001jml.2_Missense_Mutation_p.P214L|JMJD1C_uc001jmm.2_Missense_Mutation_p.P145L|JMJD1C_uc010qiq.1_Missense_Mutation_p.P251L|JMJD1C_uc009xpi.2_Missense_Mutation_p.P251L|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_Missense_Mutation_p.P145L	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	433					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTGATCCCAGGGAGGCTGGCT	0.363													41	59					0	0	0	0	A	64974629	A	A	64974629	3	1	276	1	0	0	0	0	1	0	0	0	7989	1232	43	4	6400	4	JMJD1C	10	64974629	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1123023	64974629	70560118	1017	50906											
CTNNA3	29119	broad.mit.edu	37	chr10	67862933	67862933	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accctatcagttttcccttcGgtctgaatgctggtgtgact	6	15	9	11	1	2	2	1	2	1	0	4	2	3	2	2	2	1	2	2	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:67862933G>A	uc009xpn.1	-	14	2082	c.1959C>T	c.(1957-1959)ACC>ACT	p.T653T	CTNNA3_uc001jmw.2_Silent_p.T653T	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	653					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TTTTCCCTTCGGTCTGAATGC	0.473													15	51					0	0	0	0	A	67862933	A	A	67862933	2	1	276	1	0	0	0	0	0	0	0	1	4031	1103	39	1		1	CTNNA3	10	67862933	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2888304	67862933	67671814	1018	50907											
DNA2	1763	broad.mit.edu	37	chr10	70190226	70190226	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttcttctagaagagctaaGgatttaatggactttgatct	12	15	9	5	0	3	3	0	1	3	2	3	5	3	5	0	2	1	2	0	2	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:70190226G>A	uc001jof.2	-	14	2433	c.2433C>T	c.(2431-2433)TCC>TCT	p.S811S	DNA2_uc001jog.1_Intron|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	725					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						GAAGAGCTAAGGATTTAATGG	0.358													7	16					0	0	0	0	A	70190226	A	A	70190226	2	1	276	1	0	0	0	0	0	0	0	1	4618	987	35	4		4	DNA2	10	70190226	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2327293	70190226	65344521	1019	50908											
HKDC1	80201	broad.mit.edu	37	chr10	70998852	70998852	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cacgaggagttcaggacacgGatgtggtgagccgtctgacc	9	7	15	10	3	2	2	1	2	1	0	2	6	2	5	2	4	1	1	2	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:70998852G>A	uc001jpf.3	+	5	683	c.550G>A	c.(550-552)GAT>AAT	p.D184N	HKDC1_uc010qje.1_Missense_Mutation_p.D47N	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	184					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						TCAGGACACGGATGTGGTGAG	0.512													18	15					0	0	0	0	A	70998852	A	A	70998852	3	1	276	1	0	0	0	0	1	0	0	0	7232	1174	41	2	568	2	HKDC1	10	70998852	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	808626	70998852	64535895	1020	50909											
CDH23	64072	broad.mit.edu	37	chr10	73570315	73570315	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgcgataccaaccgcatcctGgacgtggaccggtgagtcgg	8	6	14	13	6	0	1	0	1	0	0	2	4	1	3	4	4	2	1	4	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:73570315G>A	uc001jrx.3	+	60	9443	c.9066G>A	c.(9064-9066)CTG>CTA	p.L3022L	CDH23_uc001jsg.3_Silent_p.L782L|CDH23_uc001jsh.3_Silent_p.L782L|CDH23_uc001jsi.3_Silent_p.L782L|CDH23_uc001jsj.3_5'Flank|CDH23_uc010qjr.1_5'Flank	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	3022	Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						ACCGCATCCTGGACGTGGACC	0.483													20	19					0	0	0	0	A	73570315	A	A	73570315	2	1	276	1	0	0	0	0	0	0	0	1	3123	1335	47	4		4	CDH23	10	73570315	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2571463	73570315	61964432	1021	50910											
DLG5	9231	broad.mit.edu	37	chr10	79581719	79581720	+	Missense_Mutation	DNP	GG	AA	AA																															tagaagatgtctgtctgcgtGgagttattgtgctgtatcaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:79581719_79581720GG>AA	uc001jzk.2	-	15	2592_2593	c.2522_2523CC>TT	c.(2521-2523)TCC>TTT	p.S841F	DLG5_uc001jzi.2_5'Flank|DLG5_uc001jzj.2_Intron|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.S445F	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	841					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CTGTCTGCGTGGAGTTATTGTG	0.52													63	54					0	0	0	0	AA	79581720	AA	AA	79581719	3	1	276	1	0	0	0	0	1	0	0	0	4580	1335	47	4	3308	4	DLG5	10	79581719	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	6011404	79581719	55953028	1022	50911											
NRG3	10718	broad.mit.edu	37	chr10	84498353	84498353	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgcaaagaaggctaccaagGagtccgttgtgatcaatttc	12	10	11	8	1	1	2	1	1	0	1	3	3	2	3	2	2	2	3	2	2	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:84498353G>A	uc001kco.2	+	3	1001	c.974G>A	c.(973-975)GGA>GAA	p.G325E	NRG3_uc010qlz.1_Missense_Mutation_p.G325E|NRG3_uc001kcp.2_Missense_Mutation_p.G104E|NRG3_uc001kcq.2_5'UTR	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	325	EGF-like.|Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GGCTACCAAGGAGTCCGTTGT	0.393													51	31					0	0	0	0	A	84498353	A	A	84498353	3	1	276	1	0	0	0	0	1	0	0	0	10703	1174	41	2	1152	2	NRG3	10	84498353	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4916634	84498353	51036394	1023	50912											
NRG3	10718	broad.mit.edu	37	chr10	84745339	84745339	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttaagaaatgaaatacaaaGagactctgcattgaccaagt	18	9	7	7	0	1	4	0	2	1	2	1	5	1	4	1	0	2	1	1	0	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:84745339G>A	uc001kco.2	+	9	2096	c.2069G>A	c.(2068-2070)AGA>AAA	p.R690K	NRG3_uc010qlz.1_Missense_Mutation_p.R689K|NRG3_uc001kcp.2_Missense_Mutation_p.R493K|NRG3_uc001kcq.2_Missense_Mutation_p.R340K|NRG3_uc001kcr.2_Missense_Mutation_p.R364K	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	714	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GAAATACAAAGAGACTCTGCA	0.418													11	49					0	0	0	0	A	84745339	A	A	84745339	3	1	276	1	0	0	0	0	1	0	0	0	10703	942	33	2	2347	2	NRG3	10	84745339	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	246986	84745339	50789408	1024	50913											
WAPAL	23063	broad.mit.edu	37	chr10	88260013	88260013	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgattcaggccatctttactCgattcactgtttgctttggc	6	17	8	10	1	3	1	2	1	1	0	4	2	3	1	1	2	2	2	1	2	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:88260013C>T	uc001kdo.2	-	3	1429	c.987G>A	c.(985-987)TCG>TCA	p.S329S	WAPAL_uc001kdn.2_Silent_p.S372S|WAPAL_uc009xsw.2_Silent_p.S329S	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	329	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						CATCTTTACTCGATTCACTGT	0.458													16	80					0	0	0	0	T	88260013	T	T	88260013	2	4	276	1	0	0	0	0	0	0	0	1	17316	871	31	1		1	WAPAL	10	88260013	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3514674	88260013	47274734	1025	50914											
TLL2	7093	broad.mit.edu	37	chr10	98157001	98157001	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgctgctgcggaactccacCcagagccggctgtccgtgga	6	7	13	15	3	0	1	0	0	0	1	2	3	2	3	4	3	5	3	4	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:98157001C>T	uc001kml.1	-	11	1552	c.1326G>A	c.(1324-1326)TGG>TGA	p.W442*	TLL2_uc009xvf.1_Nonsense_Mutation_p.W420*	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	442	CUB 1.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GGAACTCCACCCAGAGCCGGC	0.582													19	18					0	0	0	0	T	98157001	T	T	98157001	4	4	276	1	0	0	0	0	0	1	0	0	16012	624	22	4	1765	4	TLL2	10	98157001	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	9896988	98157001	37377746	1026	50915											
C10orf28	27291	broad.mit.edu	37	chr10	99968599	99968599	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aataaaactaagctctgattCtgaaattgtacaacaaagca	19	10	5	7	0	2	2	0	2	2	0	2	2	2	2	0	0	5	3	0	0	8	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:99968599C>T	uc001kow.3	+	4	1023	c.728C>T	c.(727-729)TCT>TTT	p.S243F	C10orf28_uc001kox.3_Missense_Mutation_p.S243F|C10orf28_uc001koy.3_Missense_Mutation_p.S243F|C10orf28_uc009xvx.2_Missense_Mutation_p.S243F|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	243							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		AGCTCTGATTCTGAAATTGTA	0.393													36	12					0	0	0	0	T	99968599	T	T	99968599	3	4	276	1	0	0	0	0	1	0	0	0	1607	913	32	2	730	2	C10orf28	10	99968599	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1811598	99968599	35566148	1027	50916											
C10orf28	27291	broad.mit.edu	37	chr10	99968919	99968919	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tacatgtaaagcacgaacctCctgatacagctgtccttgct	11	11	7	12	1	0	1	0	1	0	0	2	2	2	1	3	0	6	4	3	0	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:99968919C>T	uc001kow.3	+	4	1343	c.1048C>T	c.(1048-1050)CCT>TCT	p.P350S	C10orf28_uc001kox.3_Missense_Mutation_p.P350S|C10orf28_uc001koy.3_Missense_Mutation_p.P350S|C10orf28_uc009xvx.2_Missense_Mutation_p.P350S|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	350							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		GCACGAACCTCCTGATACAGC	0.398													19	81					0	0	0	0	T	99968919	T	T	99968919	3	4	276	1	0	0	0	0	1	0	0	0	1607	855	30	2	1050	2	C10orf28	10	99968919	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	320	99968919	35565828	1028	50917											
LOXL4	84171	broad.mit.edu	37	chr10	100016640	100016640	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgctcccccagcgtgggaccCcgttcacctccacctgcacc	5	6	8	22	3	1	0	1	0	0	0	3	1	3	1	8	1	2	3	8	1	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:100016640C>T	uc001kpa.1	-	9	1476	c.1325G>A	c.(1324-1326)GGG>GAG	p.G442E		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	442	SRCR 4.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		GCGTGGGACCCCGTTCACCTC	0.612													13	43					0	0	0	0	T	100016640	T	T	100016640	3	4	276	1	0	0	0	0	1	0	0	0	8952	623	22	4	973	4	LOXL4	10	100016640	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	47721	100016640	35518107	1029	50918											
PYROXD2	84795	broad.mit.edu	37	chr10	100174846	100174847	+	Missense_Mutation	DNP	GG	AA	AA																															ctcgtctccacgccgggaagGgagaggcggccacagccttg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:100174846_100174847GG>AA	uc001kpc.2	-	1	132_133	c.46_47CC>TT	c.(46-48)CCC>TTC	p.P16F	PYROXD2_uc001kpd.2_RNA|PYROXD2_uc010qpe.1_Missense_Mutation_p.P16F	NM_032709	NP_116098	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase	16							oxidoreductase activity			central_nervous_system(1)	1						CGCCGGGAAGGGAGAGGCGGCC	0.594													23	64					0	0	0	0	AA	100174847	AA	AA	100174846	3	1	276	1	0	0	0	0	1	0	0	0	12932	1232	43	4	1762	4	PYROXD2	10	100174846	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	158206	100174846	35359901	1030	50919											
HPS1	3257	broad.mit.edu	37	chr10	100179847	100179847	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taggagcagtagaaatccccCtcctggaacagcagcgtggt	11	7	12	11	1	0	1	0	0	0	1	2	3	2	3	3	3	4	3	3	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:100179847C>T	uc010qpf.1	-	18	2058	c.1812G>A	c.(1810-1812)GAG>GAA	p.E604E	HPS1_uc001kpi.1_Silent_p.E605E|HPS1_uc001kpj.1_Silent_p.E512E|HPS1_uc001kpk.1_Silent_p.E429E	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	604					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		AGAAATCCCCCTCCTGGAACA	0.582									Hermansky-Pudlak_syndrome				58	102					0	0	0	0	T	100179847	T	T	100179847	2	4	276	1	0	0	0	0	0	0	0	1	7378	680	24	4		4	HPS1	10	100179847	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5001	100179847	35354900	1031	50920											
GOT1	2805	broad.mit.edu	37	chr10	101163324	101163324	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccgcacgatcttctccatCtgggaaaggacttgcaggat	10	10	10	11	2	3	0	0	0	3	0	5	4	4	3	2	3	1	2	2	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:101163324C>T	uc001kpr.2	-	7	1069	c.861G>A	c.(859-861)CAG>CAA	p.Q287Q	GOT1_uc009xwh.2_RNA|GOT1_uc001kpq.1_5'UTR	NM_002079	NP_002070	P17174	AATC_HUMAN	aspartate aminotransferase 1	287					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding				0		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TCTTCTCCATCTGGGAAAGGA	0.537													47	77					0	0	0	0	T	101163324	T	T	101163324	2	4	276	1	0	0	0	0	0	0	0	1	6616	912	32	2		2	GOT1	10	101163324	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	983477	101163324	34371423	1032	50921											
ABCC2	1244	broad.mit.edu	37	chr10	101556903	101556903	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgacactcgaggatgtctggGaagttgatgaagagatgaaa	14	9	14	4	1	1	5	0	4	1	1	2	9	1	7	0	2	0	1	0	2	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:101556903G>A	uc001kqf.2	+	7	821	c.682G>A	c.(682-684)GAA>AAA	p.E228K		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	228	Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGATGTCTGGGAAGTTGATGA	0.527													43	30					0	0	0	0	A	101556903	A	A	101556903	3	1	276	1	0	0	0	0	1	0	0	0	53	1175	41	2	708	2	ABCC2	10	101556903	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	393579	101556903	33977844	1033	50922											
CPN1	1369	broad.mit.edu	37	chr10	101816815	101816816	+	Missense_Mutation	DNP	CC	TT	TT																															tcccgattacccagccactcCcgctgtaactcctcttcggg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:101816815_101816816CC>TT	uc001kql.2	-	6	1225_1226	c.965_966GG>AA	c.(964-966)CGG>CAA	p.R322Q		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	322	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		CCAGCCACTCCCGCTGTAACTC	0.455													196	96					0	0	0	0	TT	101816816	TT	TT	101816815	3	4	276	1	0	0	0	0	1	0	0	0	3824	610	22	4	426	4	CPN1	10	101816815	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	259912	101816815	33717932	1034	50923											
CPN1	1369	broad.mit.edu	37	chr10	101824951	101824951	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcttctccacataccttctgGaagagcttgtcgtcaggcgt	7	12	10	12	2	3	1	1	0	2	1	5	2	3	2	2	2	2	2	2	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:101824951G>A	uc001kql.2	-	4	1013	c.753C>T	c.(751-753)TTC>TTT	p.F251F		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	251	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		ATACCTTCTGGAAGAGCTTGT	0.612													45	34					0	0	0	0	A	101824951	A	A	101824951	2	1	276	1	0	0	0	0	0	0	0	1	3824	1165	41	2		2	CPN1	10	101824951	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	8136	101824951	33709796	1035	50924											
CHUK	1147	broad.mit.edu	37	chr10	101982730	101982730	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcctttacaacattggcatGgttcaacctaataagaaaga	15	10	8	8	0	1	2	1	0	0	2	1	2	1	2	2	3	3	2	2	3	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:101982730G>A	uc001kqp.2	-	3	263	c.208C>T	c.(208-210)CAT>TAT	p.H70Y		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	70	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		ACATTGGCATGGTTCAACCTA	0.338													35	18					0	0	0	0	A	101982730	A	A	101982730	3	1	276	1	0	0	0	0	1	0	0	0	3431	1348	47	4	2105	4	CHUK	10	101982730	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	157779	101982730	33552017	1036	50925											
SEC31B	25956	broad.mit.edu	37	chr10	102249490	102249490	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggtttcccctgggggcTggggcttctttccaggaatc	4	12	15	10	0	1	0	0	0	1	0	4	2	3	2	3	7	0	3	3	7	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:102249490T>A	uc001krc.1	-	22	3096	c.2994A>T	c.(2992-2994)CCA>CCT	p.P998P	SEC31B_uc010qpo.1_Silent_p.P997P|SEC31B_uc001krd.1_Silent_p.P535P|SEC31B_uc001krf.1_Silent_p.P430P|SEC31B_uc001kre.1_Silent_p.P430P	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	998	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CCCTGGGGGCTGGGGCTTCTT	0.468													14	76					0	0	0	0	A	102249490	A	A	102249490	2	1	276	1	0	0	0	0	0	0	0	1	14064	1567	55	5		5	SEC31B	10	102249490	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	266760	102249490	33285257	1037	50926											
NOLC1	9221	broad.mit.edu	37	chr10	103920272	103920272	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtaccaccaagaattcttCaaataagccagctgtcacca	14	9	6	12	0	3	1	2	0	1	1	3	1	3	1	4	1	3	2	4	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:103920272C>T	uc001kuo.2	+	10	1398	c.1163C>T	c.(1162-1164)TCA>TTA	p.S388L	NOLC1_uc001kup.2_Missense_Mutation_p.S398L|NOLC1_uc001kuq.2_Missense_Mutation_p.S389L|NOLC1_uc009xxb.1_Missense_Mutation_p.S107L|NOLC1_uc001kur.2_Missense_Mutation_p.S107L	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	388	Nuclear localization signal (Potential).|11 X 12 AA approximate repeats of an acidic serine cluster.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		AAGAATTCTTCAAATAAGCCA	0.532													25	74					0	0	0	0	T	103920272	T	T	103920272	3	4	276	1	0	0	0	0	1	0	0	0	10583	838	29	2	1201	2	NOLC1	10	103920272	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1670782	103920272	31614475	1038	50927											
PSD	5662	broad.mit.edu	37	chr10	104173829	104173829	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgaggctggtataggaggtgCctttggcccggtgtgactcc	5	10	16	10	2	0	1	0	1	0	0	1	3	1	2	3	6	1	2	3	6	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:104173829C>T	uc001kvg.1	-	5	1777	c.1250G>A	c.(1249-1251)GGC>GAC	p.G417D	PSD_uc001kvh.1_Missense_Mutation_p.G38D|PSD_uc009xxd.1_Missense_Mutation_p.G417D	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	417					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		ATAGGAGGTGCCTTTGGCCCG	0.622													16	45					0	0	0	0	T	104173829	T	T	104173829	3	4	276	1	0	0	0	0	1	0	0	0	12708	739	26	4	1876	4	PSD	10	104173829	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	253557	104173829	31360918	1039	50928											
TAF5	6877	broad.mit.edu	37	chr10	105139526	105139526	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccaatgctccacctcagaaCaggtgaggaaaaaacttcag	15	6	8	12	0	2	2	2	1	0	1	3	3	3	3	3	2	3	1	3	2	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:105139526C>G	uc001kwv.2	+	4	1298	c.1275C>G	c.(1273-1275)AAC>AAG	p.N425K	TAF5_uc010qqq.1_Missense_Mutation_p.N425K	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	425					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		CACCTCAGAACAGGTGAGGAA	0.353													11	32					0	0	0	0	G	105139526	G	G	105139526	3	3	276	1	0	0	0	0	1	0	0	0	15594	477	17	4	1289	4	TAF5	10	105139526	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	965697	105139526	30395221	1040	50929											
SH3PXD2A	9644	broad.mit.edu	37	chr10	105362544	105362544	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctcctagacccctcactggGagcctcggaggccgtctgcg	5	8	12	16	3	3	1	1	0	2	1	5	3	3	3	5	3	2	0	5	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:105362544G>A	uc001kxj.1	-	14	2487	c.2347C>T	c.(2347-2349)CCC>TCC	p.P783S	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Missense_Mutation_p.P618S|SH3PXD2A_uc010qqt.1_Missense_Mutation_p.P660S|SH3PXD2A_uc009xxn.1_Missense_Mutation_p.P618S|SH3PXD2A_uc010qqu.1_Missense_Mutation_p.P726S	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	811					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		CCCTCACTGGGAGCCTCGGAG	0.647													33	115					0	0	0	0	A	105362544	A	A	105362544	3	1	276	1	0	0	0	0	1	0	0	0	14321	1174	41	2	974	2	SH3PXD2A	10	105362544	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	223018	105362544	30172203	1041	50930											
COL17A1	1308	broad.mit.edu	37	chr10	105807536	105807537	+	Missense_Mutation	DNP	GG	AA	AA																															agaaggtcctggtgggccacGgattccaggcatcccagtaa																								rs138894227	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:105807536_105807537GG>AA	uc001kxr.2	-	31	2464_2465	c.2295_2296CC>TT	c.(2293-2298)ATCCGT>ATTTGT	p.R766C		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	766	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGTGGGCCACGGATTCCAGGCA	0.45													26	24					0	0	0	0	AA	105807537	AA	AA	105807536	3	1	276	1	0	0	0	0	1	0	0	0	3689	1116	39	1	2301	1	COL17A1	10	105807536	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	444992	105807536	29727211	1042	50931											
SORCS3	22986	broad.mit.edu	37	chr10	106970961	106970961	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttctggtacaatccagcatcCccatcaaaggactgcagcct	11	9	7	14	0	2	0	1	0	1	0	4	1	4	1	4	2	4	3	4	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:106970961C>T	uc001kyi.1	+	17	2555	c.2328C>T	c.(2326-2328)TCC>TCT	p.S776S	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	776	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ATCCAGCATCCCCATCAAAGG	0.453													9	35					0	0	0	0	T	106970961	T	T	106970961	2	4	276	1	0	0	0	0	0	0	0	1	14996	610	22	4		4	SORCS3	10	106970961	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1163425	106970961	28563786	1043	50932											
KIAA1598	57698	broad.mit.edu	37	chr10	118661444	118661444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggcatggatttggactctGaggtggctaatatcccagtt	8	13	12	8	0	1	1	0	1	1	0	2	3	2	3	1	5	0	3	1	5	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:118661444G>A	uc009xyw.2	-	16	2003	c.1505C>T	c.(1504-1506)TCA>TTA	p.S502L	KIAA1598_uc001lcz.3_Intron|KIAA1598_uc010qso.1_Missense_Mutation_p.S442L|KIAA1598_uc010qsp.1_Missense_Mutation_p.S502L|KIAA1598_uc010qsq.1_Missense_Mutation_p.S442L|KIAA1598_uc001lcy.3_Missense_Mutation_p.S472L	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	502					axon guidance	axon					0				all cancers(201;0.00494)		TTTGGACTCTGAGGTGGCTAA	0.408													4	25					0	0	0	0	A	118661444	A	A	118661444	3	1	276	1	0	0	0	0	1	0	0	0	8285	1294	45	2	398	2	KIAA1598	10	118661444	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	11690483	118661444	16873303	1044	50933											
WDR11	55717	broad.mit.edu	37	chr10	122660595	122660596	+	Missense_Mutation	DNP	TG	GT	GT																															gaatctcctccaagaacagtTgaattcattgtctaagtaag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:122660595_122660596TG>GT	uc010qtf.1	+	21	2910_2911	c.2672_2673TG>GT	c.(2671-2673)TTG>TGT	p.L891C	WDR11_uc010qte.1_Missense_Mutation_p.L493C|WDR11_uc001lfd.1_Missense_Mutation_p.L409C|WDR11_uc009xzn.2_Missense_Mutation_p.L182C	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	891						integral to membrane					0						CAAGAACAGTTGAATTCATTGT	0.282													20	55					0	0	0	0	GT	122660596	GT	GT	122660595	3	3	276	1	0	0	0	0	1	0	0	0	17341	1821	63	5	2754	5	WDR11	10	122660595	Missense_Mutation	DNP	TG	TCGA-D6-6516-01A-11D-1870-08	3999151	122660595	12874152	1045	50934											
WDR11	55717	broad.mit.edu	37	chr10	122662636	122662637	+	Missense_Mutation	DNP	GG	AA	AA																															tacctgcacagcttatcccaGgaaaagtcagccagcacaac																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:122662636_122662637GG>AA	uc010qtf.1	+	23	3061_3062	c.2823_2824GG>AA	c.(2821-2826)CAGGAA>CAAAAA	p.E942K	WDR11_uc010qte.1_Missense_Mutation_p.E544K|WDR11_uc001lfd.1_Missense_Mutation_p.E460K|WDR11_uc009xzn.2_Missense_Mutation_p.E233K	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	942						integral to membrane					0						GCTTATCCCAGGAAAAGTCAGC	0.5													6	37					0	0	0	0	AA	122662637	AA	AA	122662636	3	1	276	1	0	0	0	0	1	0	0	0	17341	991	35	4	2913	4	WDR11	10	122662636	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	2041	122662636	12872111	1046	50935											
DMBT1	1755	broad.mit.edu	37	chr10	124345745	124345745	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtggctgggccatgttggcCccaggaaatgcccggtttgg	5	10	16	10	1	0	0	0	0	0	0	0	1	0	1	4	6	1	3	4	6	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:124345745C>T	uc001lgk.1	+	16	1735	c.1629C>T	c.(1627-1629)GCC>GCT	p.A543A	DMBT1_uc001lgl.1_Silent_p.A533A|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Silent_p.A543A|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Intron	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	543	SRCR 4.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCATGTTGGCCCCAGGAAATG	0.602													62	180					0	0	0	0	T	124345745	T	T	124345745	2	4	276	1	0	0	0	0	0	0	0	1	4599	610	22	4		4	DMBT1	10	124345745	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1683109	124345745	11189002	1047	50936											
FAM175B	23172	broad.mit.edu	37	chr10	126523370	126523370	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaagtggggctgaccttcctCctccccaaagagcagctgga	9	7	12	13	0	0	2	0	1	0	1	3	4	3	3	5	3	2	3	5	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:126523370C>T	uc001lib.3	+	9	1123	c.1078C>T	c.(1078-1080)CCT>TCT	p.P360S		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	360						BRISC complex	polyubiquitin binding				0						TGACCTTCCTCCTCCCCAAAG	0.488													16	34					0	0	0	0	T	126523370	T	T	126523370	3	4	276	1	0	0	0	0	1	0	0	0	5526	855	30	2	1112	2	FAM175B	10	126523370	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2177625	126523370	9011377	1048	50937											
DPYSL4	10570	broad.mit.edu	37	chr10	134016234	134016234	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agggccgagtggcgctggagGacgggaagatgtttgtcacc	8	7	18	8	3	1	1	1	0	0	1	1	5	1	4	2	5	0	2	2	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:134016234G>T	uc009ybb.2	+	12	1520	c.1366G>T	c.(1366-1368)GAC>TAC	p.D456Y		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	456					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GGCGCTGGAGGACGGGAAGAT	0.617													40	28					6.45866e-13	6.63661e-13	1	0	T	134016234	T	T	134016234	3	4	276	1	0	0	0	0	1	0	0	0	4771	1174	41	2	1412	2	DPYSL4	10	134016234	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7492864	134016234	1518513	1049	50938											
DPYSL4	10570	broad.mit.edu	37	chr10	134016249	134016249	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggacgggaagatgtttGtcaccccgggggcgggccgc	6	6	19	10	4	1	1	1	0	0	1	1	4	1	4	3	6	0	1	3	6	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:134016249G>T	uc009ybb.2	+	12	1535	c.1381G>T	c.(1381-1383)GTC>TTC	p.V461F		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	461					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GAAGATGTTTGTCACCCCGGG	0.622													26	47					7.38237e-10	7.54602e-10	1	0	T	134016249	T	T	134016249	3	4	276	1	0	0	0	0	1	0	0	0	4771	1377	48	4	1427	4	DPYSL4	10	134016249	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	15	134016249	1518498	1050	50939											
GPR123	84435	broad.mit.edu	37	chr10	134942170	134942170	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggcgctggcggtgtcacagGgccacttcctggacatggtc	5	8	16	12	2	1	0	1	0	0	0	3	1	2	1	2	6	0	1	2	6	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:134942170G>A	uc001llx.3	+	7	1274	c.838G>A	c.(838-840)GGC>AGC	p.G280S	GPR123_uc001llw.2_Missense_Mutation_p.G999S	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	280	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GGTGTCACAGGGCCACTTCCT	0.652													18	8					0	0	0	0	A	134942170	A	A	134942170	3	1	276	1	0	0	0	0	1	0	0	0	6675	1232	43	4	860	4	GPR123	10	134942170	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	925921	134942170	592577	1051	50940											
SYCE1	93426	broad.mit.edu	37	chr10	135369503	135369503	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	accttccttgagcagctgctCcttgctgctgtccagggcac	5	11	10	15	0	0	1	0	1	0	0	3	1	3	1	4	1	5	6	4	1	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr10:135369503C>T	uc001lno.2	-	9	682	c.577G>A	c.(577-579)GAG>AAG	p.E193K	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Missense_Mutation_p.E65K|SYCE1_uc009ybn.2_Missense_Mutation_p.E193K|SYCE1_uc001lnn.2_Missense_Mutation_p.E157K	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	193	Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		AGCAGCTGCTCCTTGCTGCTG	0.582													24	53					0	0	0	0	T	135369503	T	T	135369503	3	4	276	1	0	0	0	0	1	0	0	0	15494	864	30	2	541	2	SYCE1	10	135369503	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	427333	135369503	165244	1052	50941											
ANO9	338440	broad.mit.edu	37	chr11	432045	432045	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acaacgaagttcacgattcgGattctgagactcaagagcca	14	8	9	10	3	3	2	2	1	1	2	4	6	3	3	1	1	2	1	1	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:432045G>A	uc001lpi.2	-	5	445	c.360C>T	c.(358-360)ATC>ATT	p.I120I	ANO9_uc001lph.2_5'Flank|ANO9_uc010qvv.1_5'UTR	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	120	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TCACGATTCGGATTCTGAGAC	0.637													8	45					0	0	0	0	A	432045	A	A	432045	2	1	276	1	0	0	0	0	0	0	0	1	704	1164	41	2		2	ANO9	11	432045	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08		432045	134574471	1053	50942											
PHRF1	57661	broad.mit.edu	37	chr11	607230	607230	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcaaggcaggtcccgcaccCccgcccgcaccgcgggggcg	5	2	15	19	6	1	0	1	0	0	0	2	0	2	0	5	4	0	3	5	4	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:607230C>T	uc001lqe.2	+	14	1905	c.1774C>T	c.(1774-1776)CCC>TCC	p.P592S	PHRF1_uc010qwc.1_Missense_Mutation_p.P591S|PHRF1_uc010qwd.1_Missense_Mutation_p.P590S|PHRF1_uc010qwe.1_Missense_Mutation_p.P588S|PHRF1_uc009ybz.1_Missense_Mutation_p.P382S|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	592							RNA polymerase binding|zinc ion binding				0						GTCCCGCACCCCCGCCCGCAC	0.701													19	27					0	0	0	0	T	607230	T	T	607230	3	4	276	1	0	0	0	0	1	0	0	0	11916	623	22	4	1821	4	PHRF1	11	607230	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	175185	607230	134399286	1054	50943											
MUC6	4588	broad.mit.edu	37	chr11	1018644	1018644	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttgtttgagtggtctctGtggctgtgggcctcgtgggt	1	17	16	7	1	2	1	0	1	2	0	4	1	2	1	1	4	0	2	1	4	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:1018644G>T	uc001lsw.2	-	31	4208	c.4157C>A	c.(4156-4158)ACA>AAA	p.T1386K		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1386	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGTGGTCTCTGTGGCTGTGGG	0.627													38	175					9.62906e-15	9.93462e-15	1	0	T	1018644	T	T	1018644	3	4	276	1	0	0	0	0	1	0	0	0	10033	1377	48	4	3174	4	MUC6	11	1018644	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	411414	1018644	133987872	1055	50944											
MUC5B	727897	broad.mit.edu	37	chr11	1156179	1156180	+	Missense_Mutation	DNP	CC	TT	TT																															cccttcagccagtctggggtCctcattcagcagagcagcag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:1156179_1156180CC>TT	uc009ycr.1	+	6	630_631	c.504_505CC>TT	c.(502-507)GTCCTC>GTTTTC	p.L169F		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	165	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGTCTGGGGTCCTCATTCAGCA	0.653													7	44					0	0	0	0	TT	1156180	TT	TT	1156179	3	4	276	1	0	0	0	0	1	0	0	0	10032	870	30	2		2	MUC5B	11	1156179	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	137535	1156179	133850337	1056	50945											
KRTAP5-4	387267	broad.mit.edu	37	chr11	1643015	1643015	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccccttggagcccccacaGgagccacagccccccttgga	7	4	9	21	0	0	0	0	0	0	0	0	3	0	3	9	3	3	0	9	3	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:1643015G>A	uc009ycy.1	-	3	534	c.447C>T	c.(445-447)TCC>TCT	p.S149S		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	163	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCCCCACAGGAGCCACAGC	0.682													7	170					0	0	0	0	A	1643015	A	A	1643015	2	1	276	1	0	0	0	0	0	0	0	1	8603	987	35	4		4	KRTAP5-4	11	1643015	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	486836	1643015	133363501	1057	50946											
KRTAP5-4	387267	broad.mit.edu	37	chr11	1643054	1643054	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacccccacaggagacacaGccccccttggaacccccaca	12	2	7	20	0	0	1	0	0	0	1	0	4	0	2	7	2	3	0	7	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:1643054G>A	uc009ycy.1	-	3	495	c.408C>T	c.(406-408)GGC>GGT	p.G136G		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	150	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGGAGACACAGCCCCCCTTGG	0.672													17	116					0	0	0	0	A	1643054	A	A	1643054	2	1	276	1	0	0	0	0	0	0	0	1	8603	958	34	4		4	KRTAP5-4	11	1643054	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	39	1643054	133363462	1058	50947											
SYT8	90019	broad.mit.edu	37	chr11	1856328	1856328	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcttcttccaaaccagcaggGtagaaagatggggcacccac	12	6	11	12	0	1	2	0	0	1	2	2	2	2	2	3	3	2	4	3	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:1856328G>A	uc001lue.1	+	2	163	c.35G>A	c.(34-36)GGT>GAT	p.G12D	SYT8_uc010qxb.1_5'UTR|SYT8_uc001lud.2_Missense_Mutation_p.G12D|SYT8_uc001luf.1_5'UTR|SYT8_uc009ydb.1_5'UTR	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	12	Extracellular (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AACCAGCAGGGTAGAAAGATG	0.667													7	32					0	0	0	0	A	1856328	A	A	1856328	3	1	276	1	0	0	0	0	1	0	0	0	15546	1261	44	4	41	4	SYT8	11	1856328	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	213274	1856328	133150188	1059	50948											
TRPM5	29850	broad.mit.edu	37	chr11	2428000	2428000	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccaggtgacgaccttctggtCcagggggtctggcaggtctc	5	9	15	12	1	3	1	0	1	3	0	5	2	4	1	3	6	0	1	3	6	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:2428000C>T	uc001lwm.3	-	21	3151	c.3142G>A	c.(3142-3144)GAC>AAC	p.D1048N	TRPM5_uc010qxl.1_Missense_Mutation_p.D1048N|TRPM5_uc009ydn.2_Missense_Mutation_p.D1050N	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	1048	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		ACCTTCTGGTCCAGGGGGTCT	0.627													13	57					0	0	0	0	T	2428000	T	T	2428000	3	4	276	1	0	0	0	0	1	0	0	0	16656	855	30	2	371	2	TRPM5	11	2428000	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	571672	2428000	132578516	1060	50949											
OSBPL5	114879	broad.mit.edu	37	chr11	3109443	3109443	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctcagggctcctatttgaGgatgtggttaatgaacagct	9	12	11	9	0	1	2	1	2	0	0	2	3	2	3	2	3	2	3	2	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:3109443G>A	uc001lxk.2	-	22	2790	c.2632C>T	c.(2632-2634)CTC>TTC	p.L878F	OSBPL5_uc010qxq.1_Missense_Mutation_p.L789F|OSBPL5_uc009ydw.2_Missense_Mutation_p.L810F|OSBPL5_uc001lxl.2_Missense_Mutation_p.L810F|OSBPL5_uc001lxj.2_Missense_Mutation_p.L332F	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	878					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TCCTATTTGAGGATGTGGTTA	0.642													7	19					0	0	0	0	A	3109443	A	A	3109443	3	1	276	1	0	0	0	0	1	0	0	0	11334	1000	35	4	11	4	OSBPL5	11	3109443	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	681443	3109443	131897073	1061	50950											
ART1	417	broad.mit.edu	37	chr11	3681448	3681448	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccctatcaagggctactcCttcttccctggagaggaaga	9	9	10	13	0	2	2	1	0	1	2	4	4	4	3	4	3	1	1	4	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:3681448C>T	uc001lye.1	+	3	800	c.699C>T	c.(697-699)TCC>TCT	p.S233S	ART1_uc009yeb.1_Silent_p.S233S	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	233		NAD (By similarity).			protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	AGGGCTACTCCTTCTTCCCTG	0.597													9	38					0	0	0	0	T	3681448	T	T	3681448	2	4	276	1	0	0	0	0	0	0	0	1	999	668	24	4		4	ART1	11	3681448	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	572005	3681448	131325068	1062	50951											
PGAP2	27315	broad.mit.edu	37	chr11	3838688	3838688	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctggtgggccatcacttttCctgtgttcggcttcttcttc	2	18	9	12	1	4	0	1	0	3	0	7	0	5	0	2	3	0	2	2	3	0	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:3838688C>T	uc001lys.2	+	3	397	c.271C>T	c.(271-273)CCT>TCT	p.P91S	PGAP2_uc001lyl.2_Intron|PGAP2_uc010qxw.1_Missense_Mutation_p.P148S|PGAP2_uc010qxx.1_Intron|PGAP2_uc001lyp.3_Intron|PGAP2_uc010qxy.1_Intron|PGAP2_uc010qxz.1_Intron|PGAP2_uc001lyn.3_Intron|PGAP2_uc010qya.1_Intron|PGAP2_uc001lyr.2_Intron|PGAP2_uc010qyb.1_Intron|PGAP2_uc001lyt.2_Intron	NM_014489	NP_055304	Q9UHJ9	PGAP2_HUMAN	FGF receptor activating protein 1 isoform 1	91	Helical; (Potential).				GPI anchor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein transporter activity				0						CATCACTTTTCCTGTGTTCGG	0.602													14	57					0	0	0	0	T	3838688	T	T	3838688	3	4	276	1	0	0	0	0	1	0	0	0	11833	855	30	2	456	2	PGAP2	11	3838688	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	157240	3838688	131167828	1063	50952											
STIM1	6786	broad.mit.edu	37	chr11	4095781	4095781	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtggaggtggagaaggtcCatctggaaaagaagctgcgc	12	6	16	7	1	1	2	0	0	1	2	2	5	2	4	1	5	2	1	1	5	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:4095781C>T	uc001lyv.2	+	7	1409	c.841C>T	c.(841-843)CAT>TAT	p.H281Y	STIM1_uc009yef.2_Missense_Mutation_p.H281Y|STIM1_uc009yeg.2_Missense_Mutation_p.H108Y	NM_003156	NP_003147	Q13586	STIM1_HUMAN	stromal interaction molecule 1 precursor	281	Cytoplasmic (Potential).|Glu-rich.|Potential.				activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			pancreas(1)	1		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		GGAGAAGGTCCATCTGGAAAA	0.637													10	14					0	0	0	0	T	4095781	T	T	4095781	3	4	276	1	0	0	0	0	1	0	0	0	15349	594	21	4	867	4	STIM1	11	4095781	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	257093	4095781	130910735	1064	50953											
C11orf40	143501	broad.mit.edu	37	chr11	4594552	4594552	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttacagtaccctaaagcaagGtcttttgtcatcttctgcca	10	14	6	11	0	4	0	1	0	3	0	4	0	4	0	2	1	4	2	2	1	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:4594552G>A	uc010qyg.1	-	2	292	c.292C>T	c.(292-294)CCT>TCT	p.P98S		NM_144663	NP_653264	Q8WZ69	CK040_HUMAN	hypothetical protein LOC143501	98										ovary(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;4.28e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CTAAAGCAAGGTCTTTTGTCA	0.488													32	113					0	0	0	0	A	4594552	A	A	4594552	3	1	276	1	0	0	0	0	1	0	0	0	1645	1261	44	4	372	4	C11orf40	11	4594552	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	498771	4594552	130411964	1065	50954											
MMP26	56547	broad.mit.edu	37	chr11	5012647	5012647	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gggccaggtggtatcttaggCcatgcctttttaccaaattc	8	13	10	10	0	1	0	0	0	1	0	2	0	1	0	4	4	2	1	4	4	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:5012647C>T	uc001lzv.2	+	4	534	c.516C>T	c.(514-516)GGC>GGT	p.G172G		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	172					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTATCTTAGGCCATGCCTTTT	0.478													58	184					0	0	0	0	T	5012647	T	T	5012647	2	4	276	1	0	0	0	0	0	0	0	1	9716	726	26	4		4	MMP26	11	5012647	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	418095	5012647	129993869	1066	50955											
OR56A5	390084	broad.mit.edu	37	chr11	5989386	5989386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatgaatgtgcaggactcCatagtcagaaaactgttcat	14	11	8	8	0	3	2	3	1	0	1	4	3	4	3	1	1	2	2	1	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:5989386C>T	uc010qzu.1	-	1	339	c.339G>A	c.(337-339)ATG>ATA	p.M113I		NM_001146033	NP_001139505	P0C7T3	O56A5_HUMAN	olfactory receptor, family 56, subfamily A,	113	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	olfactory receptor activity				0						TGCAGGACTCCATAGTCAGAA	0.493													5	32					0	0	0	0	T	5989386	T	T	5989386	3	4	276	1	0	0	0	0	1	0	0	0	11190	594	21	4	604	4	OR56A5	11	5989386	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	976739	5989386	129017130	1067	50956											
OR56A5	390084	broad.mit.edu	37	chr11	5989583	5989583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagatagatggtgatcagaaGggtggcattggcccccatgg	10	8	15	8	0	1	4	1	1	0	3	1	4	1	4	2	5	0	1	2	5	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:5989583G>A	uc010qzu.1	-	1	142	c.142C>T	c.(142-144)CTT>TTT	p.L48F		NM_001146033	NP_001139505	P0C7T3	O56A5_HUMAN	olfactory receptor, family 56, subfamily A,	48	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	olfactory receptor activity				0						GTGATCAGAAGGGTGGCATTG	0.577													6	35					0	0	0	0	A	5989583	A	A	5989583	3	1	276	1	0	0	0	0	1	0	0	0	11190	1000	35	4	801	4	OR56A5	11	5989583	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	197	5989583	129016933	1068	50957											
OR52L1	338751	broad.mit.edu	37	chr11	6007757	6007757	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	catagcaatccagagccatgGccacaagtacccctgactcc	12	6	7	16	0	0	2	0	1	0	1	2	2	2	2	6	1	3	2	6	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:6007757G>A	uc001mcd.2	-	1	459	c.404C>T	c.(403-405)GCC>GTC	p.A135V		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	135	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGAGCCATGGCCACAAGTAC	0.537													5	19					0	0	0	0	A	6007757	A	A	6007757	3	1	276	1	0	0	0	0	1	0	0	0	11179	1203	42	4	589	4	OR52L1	11	6007757	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	18174	6007757	128998759	1069	50958											
OR56A1	120796	broad.mit.edu	37	chr11	6048186	6048186	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaagaatgaggatgaagtggGagccacatgtgctcagggcc	13	6	15	7	0	1	3	1	2	0	1	1	5	1	5	2	3	2	1	2	3	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:6048186G>A	uc010qzw.1	-	1	749	c.749C>T	c.(748-750)TCC>TTC	p.S250F		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATGAAGTGGGAGCCACATGT	0.498													10	56					0	0	0	0	A	6048186	A	A	6048186	3	1	276	1	0	0	0	0	1	0	0	0	11187	1174	41	2	211	2	OR56A1	11	6048186	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	40429	6048186	128958330	1070	50959											
TRIM3	10612	broad.mit.edu	37	chr11	6472240	6472240	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acaatgatatgtccattccgGtctacggccactcccttggg	8	11	9	13	2	1	1	0	1	1	0	4	1	4	1	4	3	1	0	4	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:6472240G>A	uc001mdh.2	-	10	2139	c.1752C>T	c.(1750-1752)GAC>GAT	p.D584D	TRIM3_uc001mdi.2_Silent_p.D584D|TRIM3_uc010raj.1_Silent_p.D465D|TRIM3_uc009yfd.2_Silent_p.D584D|TRIM3_uc010rak.1_Silent_p.D584D	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	584	NHL 3.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCCATTCCGGTCTACGGCCA	0.547													15	44					0	0	0	0	A	6472240	A	A	6472240	2	1	276	1	0	0	0	0	0	0	0	1	16571	1252	44	4		4	TRIM3	11	6472240	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	424054	6472240	128534276	1071	50960											
TRIM3	10612	broad.mit.edu	37	chr11	6477752	6477752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggctgtccgtagagcagcaCcgagaggagcagctcgcctt	8	7	14	12	3	0	2	0	0	0	2	2	4	1	3	3	2	4	6	3	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:6477752C>T	uc001mdh.2	-	7	1591	c.1204G>A	c.(1204-1206)GTG>ATG	p.V402M	TRIM3_uc001mdi.2_Missense_Mutation_p.V402M|TRIM3_uc010raj.1_Missense_Mutation_p.V283M|TRIM3_uc009yfd.2_Missense_Mutation_p.V402M|TRIM3_uc010rak.1_Missense_Mutation_p.V402M|TRIM3_uc001mdj.2_Missense_Mutation_p.V283M	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	402	Filamin.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGAGCAGCACCGAGAGGAGC	0.677													5	14					0	0	0	0	T	6477752	T	T	6477752	3	4	276	1	0	0	0	0	1	0	0	0	16571	507	18	4	1058	4	TRIM3	11	6477752	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5512	6477752	128528764	1072	50961											
DNHD1	144132	broad.mit.edu	37	chr11	6591316	6591316	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcaatccccgtgctgccaTgcaagagctggctggtgaga	9	8	13	11	1	0	2	0	1	0	2	1	3	1	2	3	2	5	5	3	2	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:6591316T>G	uc001mdw.3	+	40	13505	c.12941T>G	c.(12940-12942)ATG>AGG	p.M4314R	DNHD1_uc001mea.3_Missense_Mutation_p.M583R|DNHD1_uc001meb.2_Missense_Mutation_p.M582R|DNHD1_uc001mec.2_Missense_Mutation_p.M582R|DNHD1_uc010rao.1_Missense_Mutation_p.M572R|DNHD1_uc009yfg.2_5'UTR	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4314					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CGTGCTGCCATGCAAGAGCTG	0.567													17	58					0	0	0	0	G	6591316	G	G	6591316	3	3	276	1	0	0	0	0	1	0	0	0	4690	1464	51	5	13100	5	DNHD1	11	6591316	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	113564	6591316	128415200	1073	50962											
OVCH2	341277	broad.mit.edu	37	chr11	7718105	7718106	+	Missense_Mutation	DNP	CC	TT	TT																															actgagcaacacatgcatttCctctggtaccagcagggtcc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:7718105_7718106CC>TT	uc010rbf.1	-	10	1047_1048	c.1047_1048GG>AA	c.(1045-1050)GAGGAA>GAAAAA	p.E350K		NM_198185	NP_937828			ovochymase 2 precursor												0				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		ACATGCATTTCCTCTGGTACCA	0.475													11	43					0	0	0	0	TT	7718106	TT	TT	7718105	3	4	276	1	0	0	0	0	1	0	0	0	11378	864	30	2	669	2	OVCH2	11	7718105	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1126789	7718105	127288411	1074	50963											
TUB	7275	broad.mit.edu	37	chr11	8120376	8120376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaaggcctcatcctccaCtttggaaagtggaaccttac	11	10	8	12	0	2	1	2	0	0	1	4	3	4	3	4	3	2	0	4	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:8120376C>T	uc001mga.2	+	9	1219	c.1070C>T	c.(1069-1071)ACT>ATT	p.T357I	TUB_uc010rbk.1_Missense_Mutation_p.T363I|TUB_uc001mfy.2_Missense_Mutation_p.T412I	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	357					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		TCATCCTCCACTTTGGAAAGT	0.478											OREG0020732	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	53					0	0	0	0	T	8120376	T	T	8120376	3	4	276	1	0	0	0	0	1	0	0	0	16810	565	20	4	1315	4	TUB	11	8120376	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	402271	8120376	126886140	1075	50964											
RIC3	79608	broad.mit.edu	37	chr11	8132603	8132604	+	Missense_Mutation	DNP	GG	AA	AA																															cagaaagttcttttgggtcaGggtaatccaccaagattgtt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:8132603_8132604GG>AA	uc001mgd.2	-	6	805_806	c.751_752CC>TT	c.(751-753)CCT>TTT	p.P251F	RIC3_uc001mgb.2_Missense_Mutation_p.P89F|RIC3_uc001mgc.2_Missense_Mutation_p.P250F|RIC3_uc001mge.2_Missense_Mutation_p.P69F|RIC3_uc010rbl.1_Missense_Mutation_p.P201F|RIC3_uc010rbm.1_Missense_Mutation_p.P279F|RIC3_uc009yfm.2_Missense_Mutation_p.P170F|RIC3_uc009yfn.2_Missense_Mutation_p.P54F	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	251	Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		TTTTGGGTCAGGGTAATCCACC	0.421													36	61					0	0	0	0	AA	8132604	AA	AA	8132603	3	1	276	1	0	0	0	0	1	0	0	0	13419	1000	35	4	361	4	RIC3	11	8132603	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	12227	8132603	126873913	1076	50965											
ZNF143	7702	broad.mit.edu	37	chr11	9492911	9492911	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aatgacagagtttcctggagGagggatggaggcgcaacatg	12	7	16	6	1	0	2	0	1	0	1	1	6	1	6	1	5	1	2	1	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:9492911G>A	uc001mhr.2	+	2	174	c.56G>A	c.(55-57)GGA>GAA	p.G19E	ZNF143_uc009yfu.2_Missense_Mutation_p.G19E|ZNF143_uc010rby.1_Missense_Mutation_p.G19E	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	19					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		TTTCCTGGAGGAGGGATGGAG	0.438													17	64					0	0	0	0	A	9492911	A	A	9492911	3	1	276	1	0	0	0	0	1	0	0	0	17799	1174	41	2	58	2	ZNF143	11	9492911	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1360308	9492911	125513605	1077	50966											
SBF2	81846	broad.mit.edu	37	chr11	9917511	9917511	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctatagaaagcactggtcaaAgggagtaatgctgcggcaat	14	8	12	7	1	1	1	1	0	0	1	1	2	1	2	0	3	3	4	0	3	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:9917511A>T	uc001mib.2	-	17	2046	c.1908T>A	c.(1906-1908)CCT>CCA	p.P636P	SBF2_uc001mif.3_Silent_p.P392P|uc001mig.2_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	636					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CACTGGTCAAAGGGAGTAATG	0.323													40	152					0	0	0	0	T	9917511	T	T	9917511	2	4	276	1	0	0	0	0	0	0	0	1	13924	59	3	5		5	SBF2	11	9917511	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	424600	9917511	125089005	1078	50967											
MICAL2	9645	broad.mit.edu	37	chr11	12257762	12257762	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagaatgacatgaacaaacgGagacggaagggcttcaccaa	17	4	12	8	2	1	4	1	2	0	2	1	7	1	5	1	3	2	1	1	3	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:12257762G>A	uc001mjz.2	+	16	2322	c.2034G>A	c.(2032-2034)CGG>CGA	p.R678R	MICAL2_uc010rch.1_Silent_p.R678R|MICAL2_uc001mka.2_Silent_p.R678R|MICAL2_uc010rci.1_Silent_p.R678R|MICAL2_uc001mkb.2_Silent_p.R678R|MICAL2_uc001mkc.2_Silent_p.R678R|MICAL2_uc001mkd.2_Silent_p.R507R|MICAL2_uc010rcj.1_Silent_p.R80R	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	678						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TGAACAAACGGAGACGGAAGG	0.552											OREG0020771	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	62					0	0	0	0	A	12257762	A	A	12257762	2	1	276	1	0	0	0	0	0	0	0	1	9623	1161	41	2		2	MICAL2	11	12257762	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2340251	12257762	122748754	1079	50968											
ANO5	203859	broad.mit.edu	37	chr11	22296187	22296187	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcttactcaacaaatgccAcacagcctatgacaggatat	15	9	6	11	0	1	1	1	1	0	0	1	2	1	2	2	1	5	1	2	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:22296187A>C	uc001mqi.2	+	20	2625	c.2308A>C	c.(2308-2310)ACA>CCA	p.T770P	ANO5_uc001mqj.2_Missense_Mutation_p.T769P	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	770	Extracellular (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						AACAAATGCCACACAGCCTAT	0.393													17	74					0	0	0	0	C	22296187	C	C	22296187	3	2	276	1	0	0	0	0	1	0	0	0	700	159	6	5	2386	5	ANO5	11	22296187	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	10038425	22296187	112710329	1080	50969											
SLC17A6	57084	broad.mit.edu	37	chr11	22364834	22364834	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccggaaaccgtggggatgatCcacggttccttcttttgggg	6	11	14	10	3	1	1	0	1	1	0	3	3	3	3	4	6	1	1	4	6	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:22364834C>T	uc001mqk.2	+	3	794	c.381C>T	c.(379-381)ATC>ATT	p.I127I		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	127	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TGGGGATGATCCACGGTTCCT	0.542													16	109					0	0	0	0	T	22364834	T	T	22364834	2	4	276	1	0	0	0	0	0	0	0	1	14486	845	30	2		2	SLC17A6	11	22364834	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	68647	22364834	112641682	1081	50970											
MUC15	143662	broad.mit.edu	37	chr11	26582706	26582706	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggctgaatcattcaaagttGgattgtagtagctagaattc	12	14	10	5	0	2	2	2	1	0	1	3	3	2	3	0	2	1	5	0	2	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:26582706G>A	uc001mqx.2	-	4	1177	c.911C>T	c.(910-912)CCA>CTA	p.P304L	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.P331L|MUC15_uc001mqy.2_Missense_Mutation_p.P281L	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	304	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						ATTCAAAGTTGGATTGTAGTA	0.378													12	35					0	0	0	0	A	26582706	A	A	26582706	3	1	276	1	0	0	0	0	1	0	0	0	10025	1348	47	4	97	4	MUC15	11	26582706	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4217872	26582706	108423810	1082	50971											
SYT13	57586	broad.mit.edu	37	chr11	45274137	45274137	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agctcctcctccgccaggggGagcaccaggccctcctccca	6	5	10	20	1	0	0	0	0	0	0	5	1	5	1	8	3	2	2	8	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:45274137G>A	uc001myq.2	-	4	807	c.681C>T	c.(679-681)CTC>CTT	p.L227L	SYT13_uc009yku.1_Silent_p.L83L	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	227	Cytoplasmic (Potential).|C2 1.					transport vesicle				ovary(1)	1						CCGCCAGGGGGAGCACCAGGC	0.677											OREG0020928	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	38					0	0	0	0	A	45274137	A	A	45274137	2	1	276	1	0	0	0	0	0	0	0	1	15535	1161	41	2		2	SYT13	11	45274137	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	18691431	45274137	89732379	1083	50972											
MAPK8IP1	9479	broad.mit.edu	37	chr11	45919661	45919661	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccatgacatcagcctggagGagtttgaggatgaagacctc	11	8	12	10	0	1	4	1	3	0	1	2	7	1	7	3	3	1	1	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:45919661G>A	uc001nbr.2	+	2	297	c.127G>A	c.(127-129)GAG>AAG	p.E43K	MAPK8IP1_uc010rgp.1_Missense_Mutation_p.E27K	NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	43	Asp/Glu-rich (acidic).				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		CAGCCTGGAGGAGTTTGAGGA	0.542													4	33					0	0	0	0	A	45919661	A	A	45919661	3	1	276	1	0	0	0	0	1	0	0	0	9337	1175	41	2	133	2	MAPK8IP1	11	45919661	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	645524	45919661	89086855	1084	50973											
DDB2	1643	broad.mit.edu	37	chr11	47256377	47256377	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acccatgctgtgattggttcCtggccacagcctccgtagat	7	11	10	13	1	0	2	0	1	0	1	2	2	2	2	5	2	2	3	5	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:47256377C>T	uc001neb.2	+	6	967	c.772C>T	c.(772-774)CTG>TTG	p.L258L	DDB2_uc001nec.2_Intron|DDB2_uc009yli.1_Silent_p.L194L|DDB2_uc001ned.2_Intron|DDB2_uc001nee.2_Intron|DDB2_uc001nef.2_Intron|DDB2_uc001neg.2_Silent_p.L117L|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	258	DWD box.|WD 3.			L->A: Impairs interaction with DDB1.	nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						TGATTGGTTCCTGGCCACAGC	0.537			Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				6	35					0	0	0	0	T	47256377	T	T	47256377	2	4	276	1	0	0	0	0	0	0	0	1	4341	680	24	4		4	DDB2	11	47256377	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1336716	47256377	87750139	1085	50974											
MYBPC3	4607	broad.mit.edu	37	chr11	47359002	47359002	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgccgatggcgttgaccgCgtagacgcgcatctcgtaca	8	8	12	13	7	1	2	0	1	1	1	2	3	1	2	2	1	2	4	2	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:47359002C>T	uc001nfa.3	-	24	2597	c.2542G>A	c.(2542-2544)GCG>ACG	p.A848T	MYBPC3_uc010rhl.1_RNA	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	847	Fibronectin type-III 1.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		GCGTTGACCGCGTAGACGCGC	0.662													6	36					0	0	0	0	T	47359002	T	T	47359002	3	4	276	1	0	0	0	0	1	0	0	0	10066	768	27	1	1322	1	MYBPC3	11	47359002	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	102625	47359002	87647514	1086	50975											
CELF1	10658	broad.mit.edu	37	chr11	47510497	47510497	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cttttcagaccaggtccttgGaacctggcccacaaacatct	10	10	7	14	0	2	1	1	0	1	1	3	2	3	2	4	3	2	0	4	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:47510497G>A	uc001nfl.2	-	1	80	c.70C>T	c.(70-72)CCA>TCA	p.P24S	CELF1_uc001nfm.2_Missense_Mutation_p.P24S|CELF1_uc001nfn.2_Missense_Mutation_p.P24S|CELF1_uc001nfo.1_Missense_Mutation_p.P51S|CELF1_uc010rhm.1_Missense_Mutation_p.P24S|CELF1_uc001nfp.2_Missense_Mutation_p.P51S|CELF1_uc001nfq.1_Missense_Mutation_p.P24S|CELF1_uc001nfr.1_Missense_Mutation_p.P24S	NM_001025596	NP_001020767	Q92879	CELF1_HUMAN	CUG triplet repeat, RNA-binding protein 1	24	RRM 1.				embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|ovary(1)	3						CAGGTCCTTGGAACCTGGCCC	0.483													30	95					0	0	0	0	A	47510497	A	A	47510497	3	1	276	1	0	0	0	0	1	0	0	0	3230	1174	41	2	1441	2	CELF1	11	47510497	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	151495	47510497	87496019	1087	50976											
MTCH2	23788	broad.mit.edu	37	chr11	47650568	47650568	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttacacagccacaaagaaagGatgtcacctagaaggcgagg	16	5	11	9	1	1	2	1	0	0	2	1	4	1	3	2	3	2	0	2	3	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:47650568G>A	uc010rho.1	-	9	759	c.570C>T	c.(568-570)ATC>ATT	p.I190I	MTCH2_uc001nge.2_Silent_p.I63I|MTCH2_uc010rhp.1_Silent_p.I42I	NM_014342	NP_055157	Q9Y6C9	MTCH2_HUMAN	mitochondrial carrier 2	190	Solcar 2.|Helical; (Potential).				transport	integral to membrane|mitochondrial inner membrane					0						ACAAAGAAAGGATGTCACCTA	0.453													9	21					0	0	0	0	A	47650568	A	A	47650568	2	1	276	1	0	0	0	0	0	0	0	1	9967	1164	41	2		2	MTCH2	11	47650568	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	140071	47650568	87355948	1088	50977											
NUP160	23279	broad.mit.edu	37	chr11	47861509	47861509	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgtagaggcggtggaattagGagatattccaggtactgctg	10	11	15	5	1	0	2	0	0	0	2	1	4	1	3	1	5	2	3	1	5	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:47861509G>A	uc001ngm.2	-	4	719	c.634C>T	c.(634-636)CCT>TCT	p.P212S	NUP160_uc009ylw.2_RNA|NUP160_uc001ngn.1_3'UTR	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	212					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						GTGGAATTAGGAGATATTCCA	0.463													21	88					0	0	0	0	A	47861509	A	A	47861509	3	1	276	1	0	0	0	0	1	0	0	0	10811	1174	41	2	3808	2	NUP160	11	47861509	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	210941	47861509	87145007	1089	50978											
OR4A5	81318	broad.mit.edu	37	chr11	51412038	51412038	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttacagatggccacatagcGatcacaggccatcaccacca	13	6	7	15	1	2	1	2	0	0	1	2	2	2	1	4	2	2	0	4	2	2	2	rs141762692		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:51412038G>A	uc001nhi.1	-	1	358	c.358C>T	c.(358-360)CGC>TGC	p.R120C		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GCCACATAGCGATCACAGGCC	0.468													13	44					0	0	0	0	A	51412038	A	A	51412038	3	1	276	1	0	0	0	0	1	0	0	0	11097	1058	37	1	593	1	OR4A5	11	51412038	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3550529	51412038	83594478	1090	50979											
OR4A15	81328	broad.mit.edu	37	chr11	55135800	55135800	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attcttctggtggtaatggcCtatgatcgatacatggccat	9	14	10	8	1	2	1	0	1	2	0	3	2	2	1	2	4	1	1	2	4	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:55135800C>T	uc010rif.1	+	1	441	c.441C>T	c.(439-441)GCC>GCT	p.A147A		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	147	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGGTAATGGCCTATGATCGAT	0.438													33	176					0	0	0	0	T	55135800	T	T	55135800	2	4	276	1	0	0	0	0	0	0	0	1	11094	668	24	4		4	OR4A15	11	55135800	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3723762	55135800	79870716	1091	50980											
OR4C11	219429	broad.mit.edu	37	chr11	55371161	55371161	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cggagagagcctttttcttcCctttggcactgtggtttctc	4	16	10	11	1	2	1	0	0	2	1	4	3	3	2	2	3	1	2	2	3	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:55371161C>T	uc010rii.1	-	1	689	c.689G>A	c.(688-690)GGG>GAG	p.G230E		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTTTTTCTTCCCTTTGGCACT	0.408													10	20					0	0	0	0	T	55371161	T	T	55371161	3	4	276	1	0	0	0	0	1	0	0	0	11099	623	22	4	245	4	OR4C11	11	55371161	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	235361	55371161	79635355	1092	50981											
OR4C6	219432	broad.mit.edu	37	chr11	55433433	55433433	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggcctgtggtcactcaccCcatagacaaggcaatggctg	10	7	12	12	0	2	1	2	0	0	1	2	2	2	1	3	4	0	2	3	4	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:55433433C>T	uc001nht.3	+	3	1056	c.791C>T	c.(790-792)CCC>CTC	p.P264L	OR4C6_uc010rik.1_Missense_Mutation_p.P264L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GTCACTCACCCCATAGACAAG	0.488													34	77					0	0	0	0	T	55433433	T	T	55433433	3	4	276	1	0	0	0	0	1	0	0	0	11106	623	22	4	793	4	OR4C6	11	55433433	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	62272	55433433	79573083	1093	50982											
SPRYD5	84767	broad.mit.edu	37	chr11	55652952	55652952	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagggcactcacctgtccCatctgcatgaactacttcct	9	10	7	15	0	2	2	1	1	1	1	4	2	4	2	3	1	3	2	3	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:55652952C>T	uc010rip.1	+	2	140	c.48C>T	c.(46-48)CCC>CCT	p.P16P	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	16	RING-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TCACCTGTCCCATCTGCATGA	0.493													12	127					0	0	0	0	T	55652952	T	T	55652952	2	4	276	1	0	0	0	0	0	0	0	1	15177	581	21	4		4	SPRYD5	11	55652952	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	219519	55652952	79353564	1094	50983											
OR5AS1	219447	broad.mit.edu	37	chr11	55798251	55798251	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttatcctggcagcaatggcTtatgaccgctatgcagccat	9	11	9	12	1	0	1	0	1	0	0	1	1	1	1	3	2	3	5	3	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:55798251T>C	uc010riw.1	+	1	357	c.357T>C	c.(355-357)GCT>GCC	p.A119A		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					CAGCAATGGCTTATGACCGCT	0.463													26	36					0	0	0	0	C	55798251	C	C	55798251	2	2	276	1	0	0	0	0	0	0	0	1	11200	1596	56	5		5	OR5AS1	11	55798251	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	145299	55798251	79208265	1095	50984											
OR5J2	282775	broad.mit.edu	37	chr11	55944497	55944497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcccttgctttacactgtagCcatgtctgatagaaagtgtg	9	14	9	9	0	1	2	0	1	1	1	2	2	2	2	2	0	3	2	2	0	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:55944497C>T	uc010rjb.1	+	1	404	c.404C>T	c.(403-405)GCC>GTC	p.A135V		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					TACACTGTAGCCATGTCTGAT	0.453													38	76					0	0	0	0	T	55944497	T	T	55944497	3	4	276	1	0	0	0	0	1	0	0	0	11219	739	26	4	406	4	OR5J2	11	55944497	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	146246	55944497	79062019	1096	50985											
OR5T3	390154	broad.mit.edu	37	chr11	56019871	56019871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactattttttgcaatctatCtctttaccttgataggcaat	10	19	4	8	0	2	1	0	1	2	0	3	1	2	1	1	1	3	2	1	1	7	10			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:56019871C>T	uc010rjd.1	+	1	196	c.196C>T	c.(196-198)CTC>TTC	p.L66F		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	66	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TGCAATCTATCTCTTTACCTT	0.368													21	78					0	0	0	0	T	56019871	T	T	56019871	3	4	276	1	0	0	0	0	1	0	0	0	11237	913	32	2	198	2	OR5T3	11	56019871	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	75374	56019871	78986645	1097	50986											
OR5R1	219479	broad.mit.edu	37	chr11	56184848	56184849	+	Missense_Mutation	DNP	GG	AA	AA																															ttccttagactatagattagGgggtttaacatggggatcac																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:56184848_56184849GG>AA	uc010rji.1	-	1	860_861	c.860_861CC>TT	c.(859-861)CCC>CTT	p.P287L		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TATAGATTAGGGGGTTTAACAT	0.361													18	99					0	0	0	0	AA	56184849	AA	AA	56184848	3	1	276	1	0	0	0	0	1	0	0	0	11234	1219	43	4	115	4	OR5R1	11	56184848	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	164977	56184848	78821668	1098	50987											
SLC43A1	8501	broad.mit.edu	37	chr11	57254631	57254631	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtggctgctgaagcaaggcGaacacagcactgatgaggga	13	5	15	8	1	0	3	0	3	0	0	0	5	0	4	0	3	4	4	0	3	3	0	rs142620907	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:57254631G>A	uc001nkk.2	-	14	1588	c.1470C>T	c.(1468-1470)TTC>TTT	p.F490F	SLC43A1_uc001nkl.2_Silent_p.F490F	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	490	Helical; (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						GAAGCAAGGCGAACACAGCAC	0.612													8	31					0	0	0	0	A	57254631	A	A	57254631	2	1	276	1	0	0	0	0	0	0	0	1	14696	1049	37	1		1	SLC43A1	11	57254631	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1069783	57254631	77751885	1099	50988											
OR1S2	219958	broad.mit.edu	37	chr11	57970986	57970986	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaagaagatgagtacaaagGggaagatgataactgataaa	21	6	12	2	0	0	7	0	3	0	4	0	8	0	8	0	2	2	1	0	2	8	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:57970986G>A	uc010rkb.1	-	1	668	c.668C>T	c.(667-669)CCC>CTC	p.P223L		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	223	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				GAGTACAAAGGGGAAGATGAT	0.448													18	87					0	0	0	0	A	57970986	A	A	57970986	3	1	276	1	0	0	0	0	1	0	0	0	11027	1232	43	4	312	4	OR1S2	11	57970986	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	716355	57970986	77035530	1100	50989											
OR5B3	441608	broad.mit.edu	37	chr11	58170000	58170000	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttgaatgcactcttcaCttccttgttcctcagactat	7	18	4	12	0	4	2	2	1	2	1	6	2	6	2	2	0	1	2	2	0	2	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:58170000C>T	uc010rkf.1	-	1	883	c.883G>A	c.(883-885)GTG>ATG	p.V295M		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GCACTCTTCACTTCCTTGTTC	0.433													23	138					0	0	0	0	T	58170000	T	T	58170000	3	4	276	1	0	0	0	0	1	0	0	0	11206	565	20	4	63	4	OR5B3	11	58170000	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	199014	58170000	76836516	1101	50990											
OR5AN1	390195	broad.mit.edu	37	chr11	59132056	59132056	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacattacatctctggcctGgaacctctccctcattgttt	7	15	5	14	0	3	0	1	0	2	0	5	1	3	1	3	2	3	1	3	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:59132056G>A	uc010rks.1	+	1	125	c.125G>A	c.(124-126)TGG>TAG	p.W42*		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCTCTGGCCTGGAACCTCTCC	0.418													54	114					0	0	0	0	A	59132056	A	A	59132056	4	1	276	1	0	0	0	0	0	1	0	0	11197	1357	47	4	127	4	OR5AN1	11	59132056	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	962056	59132056	75874460	1102	50991											
OR5A1	219982	broad.mit.edu	37	chr11	59211004	59211004	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcctcctcctgactgctatGgcatacgaccgatatgcagc	8	10	9	14	2	0	1	0	1	0	0	2	3	2	1	4	1	5	3	4	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:59211004G>A	uc001nnx.1	+	1	363	c.363G>A	c.(361-363)ATG>ATA	p.M121I		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	121	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						TGACTGCTATGGCATACGACC	0.532													74	192					0	0	0	0	A	59211004	A	A	59211004	3	1	276	1	0	0	0	0	1	0	0	0	11193	1348	47	4	365	4	OR5A1	11	59211004	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	78948	59211004	75795512	1103	50992											
GIF	2694	broad.mit.edu	37	chr11	59610013	59610013	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctggcacagtgccaagatCgctagactgggcccatagaa	11	8	11	11	1	1	3	0	0	1	3	2	3	1	3	2	2	1	2	2	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:59610013C>T	uc001noi.2	-	4	462	c.414G>A	c.(412-414)GCG>GCA	p.A138A	GIF_uc010rkz.1_3'UTR	NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	138					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						GTGCCAAGATCGCTAGACTGG	0.557													13	62					0	0	0	0	T	59610013	T	T	59610013	2	4	276	1	0	0	0	0	0	0	0	1	6413	871	31	1		1	GIF	11	59610013	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	399009	59610013	75396503	1104	50993											
GIF	2694	broad.mit.edu	37	chr11	59612891	59612891	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctagtcccagctgtagcccaGagaaggctcaggaggtagag	11	6	14	10	0	1	2	1	0	0	2	2	4	2	3	2	3	2	4	2	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:59612891G>A	uc001noi.2	-	1	84	c.36C>T	c.(34-36)CTC>CTT	p.L12L	GIF_uc010rkz.1_Silent_p.L12L	NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	12					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						CTGTAGCCCAGAGAAGGCTCA	0.522													53	178					0	0	0	0	A	59612891	A	A	59612891	2	1	276	1	0	0	0	0	0	0	0	1	6413	929	33	2		2	GIF	11	59612891	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2878	59612891	75393625	1105	50994											
MS4A6A	64231	broad.mit.edu	37	chr11	59945756	59945756	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcttggttaaccttttctCtgtggcgattgatagagagc	9	14	11	7	1	1	2	0	1	1	1	2	4	1	2	1	2	3	2	1	2	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:59945756C>T	uc001nor.2	-	4	554	c.316G>A	c.(316-318)GAG>AAG	p.E106K	MS4A6A_uc001noq.2_Missense_Mutation_p.E106K|MS4A6A_uc001nos.3_Missense_Mutation_p.E134K|MS4A6A_uc009ymv.2_Missense_Mutation_p.E106K|MS4A6A_uc001not.2_Missense_Mutation_p.E106K|MS4A6A_uc010rla.1_Missense_Mutation_p.E134K|MS4A6A_uc010rlb.1_Missense_Mutation_p.E61K	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	106	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						AACCTTTTCTCTGTGGCGATT	0.393													5	91					0	0	0	0	T	59945756	T	T	59945756	3	4	276	1	0	0	0	0	1	0	0	0	9917	922	32	2	473	2	MS4A6A	11	59945756	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	332865	59945756	75060760	1106	50995											
MS4A7	58475	broad.mit.edu	37	chr11	60152592	60152592	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgtgttgcctgttgatttCaagtctgggggccatcttgg	4	15	13	9	0	3	1	1	1	2	0	3	1	3	1	3	3	1	2	3	3	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:60152592C>T	uc001npe.2	+	3	324	c.179C>T	c.(178-180)TCA>TTA	p.S60L	MS4A7_uc001npf.2_Missense_Mutation_p.S60L|MS4A7_uc001npg.2_Intron|MS4A7_uc001nph.2_Intron|MS4A14_uc001npi.2_Intron|MS4A7_uc009ymx.1_Intron	NM_206939	NP_996822	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member	60	Helical; (Potential).					integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2						CTGTTGATTTCAAGTCTGGGG	0.448													67	141					0	0	0	0	T	60152592	T	T	60152592	3	4	276	1	0	0	0	0	1	0	0	0	9919	838	29	2	185	2	MS4A7	11	60152592	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	206836	60152592	74853924	1107	50996											
MS4A1	931	broad.mit.edu	37	chr11	60230539	60230540	+	Missense_Mutation	DNP	GG	AA	AA																															tcttctgatgatcccagcagGgatctatgcacccatctgtg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:60230539_60230540GG>AA	uc001npp.2	+	4	640_641	c.224_225GG>AA	c.(223-225)GGG>GAA	p.G75E	MS4A1_uc009ymy.1_Missense_Mutation_p.G75E|MS4A1_uc001npq.2_Missense_Mutation_p.G75E|MS4A1_uc009yna.2_Missense_Mutation_p.G75E|MS4A1_uc009ymz.2_Missense_Mutation_p.G75E|MS4A1_uc010rlc.1_Intron	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	75	Helical; (Potential).|Epitope 1.				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	ATCCCAGCAGGGATCTATGCAC	0.515													28	160					0	0	0	0	AA	60230540	AA	AA	60230539	3	1	276	1	0	0	0	0	1	0	0	0	9907	1232	43	4	230	4	MS4A1	11	60230539	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	77947	60230539	74775977	1108	50997											
TMEM132A	54972	broad.mit.edu	37	chr11	60696260	60696260	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgaccctggggagcaggccCtcccagtggggggtgtggag	6	5	19	11	1	0	0	0	0	0	0	1	3	1	2	3	7	1	1	3	7	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:60696260C>T	uc001nqj.2	+	4	887	c.694C>T	c.(694-696)CTC>TTC	p.L232F	TMEM132A_uc001nqi.2_Missense_Mutation_p.L232F|TMEM132A_uc001nqk.2_Missense_Mutation_p.L245F|TMEM132A_uc001nql.1_Missense_Mutation_p.L245F	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	232	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						GGAGCAGGCCCTCCCAGTGGG	0.697													6	17					0	0	0	0	T	60696260	T	T	60696260	3	4	276	1	0	0	0	0	1	0	0	0	16111	681	24	4	708	4	TMEM132A	11	60696260	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	465721	60696260	74310256	1109	50998											
CD6	923	broad.mit.edu	37	chr11	60781393	60781393	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctcccctccctcagccCtccccgtaatggtgaaccac	6	8	6	21	1	1	1	1	1	0	0	4	1	4	1	8	1	3	1	8	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:60781393C>T	uc001nqq.2	+	8	1517	c.1294C>T	c.(1294-1296)CTC>TTC	p.L432F	CD6_uc001nqp.2_Missense_Mutation_p.L432F|CD6_uc001nqr.2_Intron|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.L432F	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	432	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						TCCCTCAGCCCTCCCCGTAAT	0.547													10	27					0	0	0	0	T	60781393	T	T	60781393	3	4	276	1	0	0	0	0	1	0	0	0	3043	681	24	4	1324	4	CD6	11	60781393	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	85133	60781393	74225123	1110	50999											
C11orf9	745	broad.mit.edu	37	chr11	61548706	61548706	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtcatctgctgttcctcacCcactaccaaccctaccactg	8	11	4	18	0	3	0	2	0	1	0	4	0	4	0	5	0	4	2	5	0	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:61548706C>T	uc001nsc.1	+	21	2765	c.2669C>T	c.(2668-2670)CCC>CTC	p.P890L	C11orf9_uc001nse.1_Missense_Mutation_p.P855L|C11orf9_uc010rll.1_Missense_Mutation_p.P281L	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	890					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						TGTTCCTCACCCACTAccaac	0.353													26	82					0	0	0	0	T	61548706	T	T	61548706	3	4	276	1	0	0	0	0	1	0	0	0	1677	623	22	4	2777	4	C11orf9	11	61548706	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	767313	61548706	73457810	1111	51000											
FADS2	9415	broad.mit.edu	37	chr11	61583899	61583899	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acccaatcaccgggcaacagGtatgatcaggcgcctccggg	10	5	12	14	3	2	1	2	1	0	0	3	1	3	1	4	4	1	2	4	4	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:61583899G>T	uc001nsj.2	+	1	171	c.141_splice	c.e1+1	p.Q47_splice	FADS2_uc010rlo.1_5'UTR|FADS1_uc001nsh.2_5'Flank|FADS1_uc010rlm.1_Intron|FADS1_uc010rln.1_5'Flank|MIR1908_hsa-mir-1908|MI0008329_5'Flank	NM_004265	NP_004256	O95864	FADS2_HUMAN	fatty acid desaturase 2						electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			ovary(1)|pancreas(1)	2					Alpha-Linolenic Acid(DB00132)	CGGGCAACAGGTATGATCAGG	0.617													19	32					1.64113e-05	1.6641e-05	1	0	T	61583899	T	T	61583899	5	4	276	1	0	0	0	0	0	0	1	0	5394	1276	44	4		4	FADS2	11	61583899	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	35193	61583899	73422617	1112	51001											
AHNAK	79026	broad.mit.edu	37	chr11	62288196	62288196	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	accatgaatgtcaatatcagGagtgtcaatgcccactttag	13	11	8	9	0	3	1	3	1	0	0	3	2	3	2	2	1	1	0	2	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:62288196G>A	uc001ntl.2	-	5	13993	c.13693C>T	c.(13693-13695)CCT>TCT	p.P4565S	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4565					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCAATATCAGGAGTGTCAATG	0.448													15	96					0	0	0	0	A	62288196	A	A	62288196	3	1	276	1	0	0	0	0	1	0	0	0	414	1174	41	2	4099	2	AHNAK	11	62288196	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	704297	62288196	72718320	1113	51002											
AHNAK	79026	broad.mit.edu	37	chr11	62291267	62291267	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtcaggcatggagatcttgGgagctttgatattcatgtca	9	14	12	6	0	4	2	3	1	1	1	4	4	4	3	0	3	1	2	0	3	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:62291267G>A	uc001ntl.2	-	5	10922	c.10622C>T	c.(10621-10623)CCC>CTC	p.P3541L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3541					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GGAGATCTTGGGAGCTTTGAT	0.468													45	238					0	0	0	0	A	62291267	A	A	62291267	3	1	276	1	0	0	0	0	1	0	0	0	414	1232	43	4	7170	4	AHNAK	11	62291267	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3071	62291267	72715249	1114	51003											
AHNAK	79026	broad.mit.edu	37	chr11	62298332	62298332	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtcttgaaatgcatctcaGgcatcttaaacttgggaccc	10	11	10	10	0	3	1	1	1	3	0	4	2	3	2	1	3	2	2	1	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:62298332G>A	uc001ntl.2	-	5	3857	c.3557C>T	c.(3556-3558)CCT>CTT	p.P1186L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1186					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATGCATCTCAGGCATCTTAAA	0.527													71	365					0	0	0	0	A	62298332	A	A	62298332	3	1	276	1	0	0	0	0	1	0	0	0	414	1000	35	4	14235	4	AHNAK	11	62298332	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7065	62298332	72708184	1115	51004											
ZBTB3	79842	broad.mit.edu	37	chr11	62520304	62520305	+	Missense_Mutation	DNP	GG	AA	AA																															caggggctggggctgacgttGgggctgaggctgggggatag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:62520304_62520305GG>AA	uc001nuz.2	-	2	1104_1105	c.982_983CC>TT	c.(982-984)CCA>TTA	p.P328L		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	328	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						ggctgacgttggggctgaggct	0.337													12	69					0	0	0	0	AA	62520305	AA	AA	62520304	3	1	276	1	0	0	0	0	1	0	0	0	17601	1348	47	4	745	4	ZBTB3	11	62520304	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	221972	62520304	72486212	1116	51005											
SLC3A2	6520	broad.mit.edu	37	chr11	62651938	62651938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccccctataggatgctctgGagttttggctgcaagctggc	6	11	13	11	0	1	0	0	0	1	0	1	2	1	2	2	4	3	5	2	4	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:62651938G>A	uc001nwd.2	+	7	1227	c.1003G>A	c.(1003-1005)GAG>AAG	p.E335K	SLC3A2_uc001nwb.2_Missense_Mutation_p.E366K|SLC3A2_uc001nwc.2_Missense_Mutation_p.E336K|SLC3A2_uc001nwe.2_Missense_Mutation_p.E304K|SLC3A2_uc001nwf.2_Missense_Mutation_p.E273K|SLC3A2_uc001nwg.2_Missense_Mutation_p.E234K|SLC3A2_uc010rml.1_RNA	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	335	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						GGATGCTCTGGAGTTTTGGCT	0.502											OREG0021032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	120					0	0	0	0	A	62651938	A	A	62651938	3	1	276	1	0	0	0	0	1	0	0	0	14691	1175	41	2	1129	2	SLC3A2	11	62651938	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	131634	62651938	72354578	1117	51006											
SLC3A2	6520	broad.mit.edu	37	chr11	62655841	62655841	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggctccctcctttccttgttCcggcggctgagtgaccagcg	3	11	12	15	3	0	2	0	2	0	0	4	2	4	2	5	3	1	3	5	3	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:62655841C>T	uc001nwd.2	+	12	1793	c.1569C>T	c.(1567-1569)TTC>TTT	p.F523F	SLC3A2_uc001nwb.2_Silent_p.F554F|SLC3A2_uc001nwc.2_Silent_p.F524F|SLC3A2_uc001nwe.2_Silent_p.F492F|SLC3A2_uc001nwf.2_Silent_p.F461F|SLC3A2_uc001nwg.2_Silent_p.F422F	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	523	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						TTTCCTTGTTCCGGCGGCTGA	0.572													16	75					0	0	0	0	T	62655841	T	T	62655841	2	4	276	1	0	0	0	0	0	0	0	1	14691	854	30	2		2	SLC3A2	11	62655841	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3903	62655841	72350675	1118	51007											
PLCB3	5331	broad.mit.edu	37	chr11	64026070	64026070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaacccttcattacccacGgcttcaccatgaccacagag	12	7	7	15	1	2	2	2	1	0	1	2	3	2	3	4	2	2	1	4	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:64026070G>A	uc001nzb.2	+	11	1138	c.1138G>A	c.(1138-1140)GGC>AGC	p.G380S	PLCB3_uc009ypg.1_Missense_Mutation_p.G380S|PLCB3_uc009yph.1_Missense_Mutation_p.G313S|PLCB3_uc009ypi.2_Missense_Mutation_p.G380S	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	380	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CATTACCCACGGCTTCACCAT	0.632													17	93					0	0	0	0	A	64026070	A	A	64026070	3	1	276	1	0	0	0	0	1	0	0	0	12084	1116	39	1	1180	1	PLCB3	11	64026070	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1370229	64026070	70980446	1119	51008											
NRXN2	9379	broad.mit.edu	37	chr11	64436058	64436058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgtggtggtcaggatccCgtccaccgagatggtcacct	6	9	13	13	2	2	1	2	0	0	1	4	3	4	2	5	4	0	0	5	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:64436058C>T	uc001oar.2	-	9	1655	c.1216G>A	c.(1216-1218)GGG>AGG	p.G406R	NRXN2_uc001oas.2_Missense_Mutation_p.G375R|NRXN2_uc001oaq.2_Missense_Mutation_p.G73R	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GTCAGGATCCCGTCCACCGAG	0.572													23	100					0	0	0	0	T	64436058	T	T	64436058	3	4	276	1	0	0	0	0	1	0	0	0	10720	652	23	1	4255	1	NRXN2	11	64436058	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	409988	64436058	70570458	1120	51009											
PPP2R5B	5526	broad.mit.edu	37	chr11	64693256	64693256	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccactagcccctcctcccCcgggctgtcgcctgtgcccc	2	7	8	24	2	0	0	0	0	0	0	3	0	2	0	10	1	2	1	10	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:64693256C>T	uc001oby.2	+	2	635	c.50C>T	c.(49-51)CCC>CTC	p.P17L	PPP2R5B_uc001obz.2_Missense_Mutation_p.P17L	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	17					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						CCCTCCTCCCCCGGGCTGTCG	0.711													9	8					0	0	0	0	T	64693256	T	T	64693256	3	4	276	1	0	0	0	0	1	0	0	0	12453	623	22	4	52	4	PPP2R5B	11	64693256	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	257198	64693256	70313260	1121	51010											
PPP2R5B	5526	broad.mit.edu	37	chr11	64694328	64694328	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgagctggtggagtgtgtggGgagcacccggggtgtcctca	5	8	19	9	2	1	0	1	0	0	0	2	3	2	2	2	6	2	2	2	6	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:64694328G>A	uc001oby.2	+	3	929	c.344G>A	c.(343-345)GGG>GAG	p.G115E	PPP2R5B_uc001obz.2_Missense_Mutation_p.G115E	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	115					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						GAGTGTGTGGGGAGCACCCGG	0.652													11	35					0	0	0	0	A	64694328	A	A	64694328	3	1	276	1	0	0	0	0	1	0	0	0	12453	1232	43	4	350	4	PPP2R5B	11	64694328	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1072	64694328	70312188	1122	51011											
SYVN1	84447	broad.mit.edu	37	chr11	64897364	64897364	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagcccagcaaagcccgcagGgggcacaggcattgggggga	10	2	17	12	1	0	0	0	0	0	0	0	1	0	1	2	6	3	4	2	6	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:64897364G>A	uc001odb.2	-	14	1526	c.1432C>T	c.(1432-1434)CCT>TCT	p.P478S	SYVN1_uc001odc.2_Missense_Mutation_p.P477S|SYVN1_uc009yqc.2_Missense_Mutation_p.P426S	NM_172230	NP_757385	Q86TM6	SYVN1_HUMAN	synoviolin 1 isoform b	478	Pro-rich.|Cytoplasmic (Potential).				ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(1)	1						AAGCCCGCAGGGGGCACAGGC	0.657													5	22					0	0	0	0	A	64897364	A	A	64897364	3	1	276	1	0	0	0	0	1	0	0	0	15553	1232	43	4	433	4	SYVN1	11	64897364	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	203036	64897364	70109152	1123	51012											
SLC22A20	440044	broad.mit.edu	37	chr11	65000797	65000798	+	Missense_Mutation	DNP	CC	TT	TT																															ggcctccttcctcatcctggCcgggctcatggtgatcgcca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:65000797_65000798CC>TT	uc010roc.1	+	8	1223_1224	c.1220_1221CC>TT	c.(1219-1221)GCC>GTT	p.A407V		NM_001004326	NP_001004326	A6NK97	S22AK_HUMAN	solute carrier family 22, member 20	407	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)	1						CTCATCCTGGCCGGGCTCATGG	0.609													9	15					0	0	0	0	TT	65000798	TT	TT	65000797	3	4	276	1	0	0	0	0	1	0	0	0	14516	754	26	4		4	SLC22A20	11	65000797	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	103433	65000797	70005719	1124	51013											
PCNXL3	399909	broad.mit.edu	37	chr11	65398034	65398034	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atgctgcctccatgctgcagGttttcgacctccgcaagatc	7	11	9	14	2	0	1	0	0	0	1	4	2	2	1	4	1	4	5	4	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:65398034G>A	uc001oey.2	+	27	4429	c.4429G>A	c.(4429-4431)GTT>ATT	p.V1477I	PCNXL3_uc001oez.2_Missense_Mutation_p.V364I	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1477						integral to membrane					0						CATGCTGCAGGTTTTCGACCT	0.592													12	44					0	0	0	0	A	65398034	A	A	65398034	3	1	276	1	0	0	0	0	1	0	0	0	11647	1261	44	4	4535	4	PCNXL3	11	65398034	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	397237	65398034	69608482	1125	51014											
MUS81	80198	broad.mit.edu	37	chr11	65633309	65633309	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgcctatgatgcctgtgcCacccccaaggaacaagagac	11	5	10	15	1	0	2	0	1	0	1	0	4	0	3	6	1	3	0	6	1	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:65633309C>T	uc001ofv.3	+	15	1886	c.1533C>T	c.(1531-1533)GCC>GCT	p.A511A	MUS81_uc001ofw.3_RNA|MUS81_uc001ofx.3_Silent_p.A68A	NM_025128	NP_079404	Q96NY9	MUS81_HUMAN	MUS81 endonuclease homolog	511					DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding				0				READ - Rectum adenocarcinoma(159;0.166)		ATGCCTGTGCCACCCCCAAGG	0.627								Homologous_recombination					17	101					0	0	0	0	T	65633309	T	T	65633309	2	4	276	1	0	0	0	0	0	0	0	1	10041	581	21	4		4	MUS81	11	65633309	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	235275	65633309	69373207	1126	51015											
PACS1	55690	broad.mit.edu	37	chr11	66002814	66002814	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtgatgcagtacgtcaacgGggcagccacgacacaccagc	11	4	13	13	3	1	1	1	1	0	0	1	2	1	1	2	3	5	3	2	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:66002814G>A	uc001oha.1	+	18	2281	c.2147G>A	c.(2146-2148)GGG>GAG	p.G716E	PACS1_uc010rou.1_Missense_Mutation_p.G252E	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	716					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						TACGTCAACGGGGCAGCCACG	0.537													26	59					0	0	0	0	A	66002814	A	A	66002814	3	1	276	1	0	0	0	0	1	0	0	0	11426	1232	43	4	2217	4	PACS1	11	66002814	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	369505	66002814	69003702	1127	51016											
CD248	57124	broad.mit.edu	37	chr11	66082791	66082791	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctgaggacaagggcatctgGggcttgagggggtagctggg	7	8	20	6	0	2	2	0	2	2	0	2	3	2	3	0	7	1	4	0	7	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:66082791G>A	uc001ohm.1	-	1	1725	c.1708C>T	c.(1708-1710)CCA>TCA	p.P570S		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	570	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	AGGGCATCTGGGGCTTGAGGG	0.637													53	92					0	0	0	0	A	66082791	A	A	66082791	3	1	276	1	0	0	0	0	1	0	0	0	3004	1232	43	4	569	4	CD248	11	66082791	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	79977	66082791	68923725	1128	51017											
ACTN3	89	broad.mit.edu	37	chr11	66319003	66319003	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcctcttaaacccaggtgaGaggctgcctaggccagataa	11	8	10	12	0	1	2	0	1	1	2	2	3	2	2	4	3	2	1	4	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:66319003G>A	uc001oio.1	+	3	285	c.267G>A	c.(265-267)GAG>GAA	p.E89E	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	89	Actin-binding.|CH 1.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						ACCCAGGTGAGAGGCTGCCTA	0.547													3	22					0	0	0	0	A	66319003	A	A	66319003	2	1	276	1	0	0	0	0	0	0	0	1	206	933	33	2		2	ACTN3	11	66319003	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	236212	66319003	68687513	1129	51018											
ACTN3	89	broad.mit.edu	37	chr11	66330270	66330270	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcctctatccctgcaggggGaagtggagtttgctcgcatc	6	10	14	11	1	1	0	0	0	1	0	4	2	2	2	2	4	2	4	2	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:66330270G>A	uc001oio.1	+	21	2410	c.2392G>A	c.(2392-2394)GAA>AAA	p.E798K	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	798	EF-hand 2.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						CCTGCAGGGGGAAGTGGAGTT	0.473													31	176					0	0	0	0	A	66330270	A	A	66330270	3	1	276	1	0	0	0	0	1	0	0	0	206	1175	41	2	2470	2	ACTN3	11	66330270	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	11267	66330270	68676246	1130	51019											
ACTN3	89	broad.mit.edu	37	chr11	66330648	66330648	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttctccagtgccctctatgGggagagcgacctttgacccc	6	10	10	15	1	2	2	0	1	2	1	3	4	2	2	5	2	2	0	5	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:66330648G>A	uc001oio.1	+	22	2708	c.2690G>A	c.(2689-2691)GGG>GAG	p.G897E	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	897					focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						GCCCTCTATGGGGAGAGCGAC	0.622													14	62					0	0	0	0	A	66330648	A	A	66330648	3	1	276	1	0	0	0	0	1	0	0	0	206	1232	43	4	2772	4	ACTN3	11	66330648	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	378	66330648	68675868	1131	51020											
RBM14	10432	broad.mit.edu	37	chr11	66391953	66391953	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtggctttgatgggcaagcCcgtcagcccacaccaccctt	7	8	11	15	1	1	1	1	1	0	0	1	1	1	1	4	3	2	2	4	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:66391953C>T	uc001oit.2	+	2	745	c.606C>T	c.(604-606)GCC>GCT	p.A202A	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	202					DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						ATGGGCAAGCCCGTCAGCCCA	0.632													10	55					0	0	0	0	T	66391953	T	T	66391953	2	4	276	1	0	0	0	0	0	0	0	1	13180	610	22	4		4	RBM14	11	66391953	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	61305	66391953	68614563	1132	51021											
SPTBN2	6712	broad.mit.edu	37	chr11	66460040	66460040	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tagtcctggcccagctcgtgGgaggccgccaccacctcgcg	5	6	13	17	4	0	0	0	0	0	0	3	1	1	1	6	3	1	1	6	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:66460040G>A	uc001ojd.2	-	25	5229	c.5157C>T	c.(5155-5157)TCC>TCT	p.S1719S		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1719	Spectrin 14.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCAGCTCGTGGGAGGCCGCCA	0.662													13	48					0	0	0	0	A	66460040	A	A	66460040	2	1	276	1	0	0	0	0	0	0	0	1	15186	1219	43	4		4	SPTBN2	11	66460040	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	68087	66460040	68546476	1133	51022											
SPTBN2	6712	broad.mit.edu	37	chr11	66463938	66463938	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccagctcgtcccagcgcCtgtgcaggtctctcagcttc	4	11	9	17	2	3	0	1	0	2	0	8	0	4	0	3	1	4	3	3	1	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:66463938C>T	uc001ojd.2	-	20	4160	c.4088G>A	c.(4087-4089)AGG>AAG	p.R1363K		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1363	Spectrin 10.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GTCCCAGCGCCTGTGCAGGTC	0.602													21	137					0	0	0	0	T	66463938	T	T	66463938	3	4	276	1	0	0	0	0	1	0	0	0	15186	681	24	4	3156	4	SPTBN2	11	66463938	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3898	66463938	68542578	1134	51023											
ALDH3B2	222	broad.mit.edu	37	chr11	67433649	67433649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctgccctgtctcctggggtCcgcccagcaccacggcaaag	6	6	12	17	2	1	0	0	0	1	0	3	0	2	0	5	3	2	3	5	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:67433649C>T	uc001omr.2	-	6	702	c.263G>A	c.(262-264)GGA>GAA	p.G88E	ALDH3B2_uc001oms.2_Missense_Mutation_p.G88E|ALDH3B2_uc009ysa.1_Missense_Mutation_p.G88E	NM_000695	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3B2	88					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			lung(1)|kidney(1)	2					NADH(DB00157)	CTCCTGGGGTCCGCCCAGCAC	0.642													16	100					0	0	0	0	T	67433649	T	T	67433649	3	4	276	1	0	0	0	0	1	0	0	0	500	855	30	2	914	2	ALDH3B2	11	67433649	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	969711	67433649	67572867	1135	51024											
SHANK2	22941	broad.mit.edu	37	chr11	70506043	70506043	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggtgttggtgtgaattcttCaatgggtgtgtcagctggga	6	14	16	5	1	3	1	2	1	1	0	3	2	3	2	0	4	1	2	0	4	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:70506043C>T	uc001oqc.2	-	14	2029	c.1951G>A	c.(1951-1953)GAA>AAA	p.E651K	SHANK2_uc010rqn.1_Missense_Mutation_p.E63K|SHANK2_uc001opz.2_Missense_Mutation_p.E63K|uc009ysn.1_Intron|SHANK2_uc010rqp.1_Missense_Mutation_p.E63K	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	272	PDZ.				intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GTGAATTCTTCAATGGGTGTG	0.582													4	43					0	0	0	0	T	70506043	T	T	70506043	3	4	276	1	0	0	0	0	1	0	0	0	14330	835	29	2	3638	2	SHANK2	11	70506043	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3072394	70506043	64500473	1136	51025											
FCHSD2	9873	broad.mit.edu	37	chr11	72553697	72553697	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcatccatggagtgtcaccaTtttctgaggctgaaagttct	9	14	9	9	0	4	2	2	2	2	0	5	3	5	3	2	2	0	2	2	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:72553697T>A	uc009ytl.2	-	17	2116	c.1895A>T	c.(1894-1896)AAT>ATT	p.N632I	FCHSD2_uc010rrg.1_Missense_Mutation_p.N496I|FCHSD2_uc001oth.3_Missense_Mutation_p.N576I|ATG16L2_uc009ytj.1_3'UTR	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	632							protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			AGTGTCACCATTTTCTGAGGC	0.438													19	149					0	0	0	0	A	72553697	A	A	72553697	3	1	276	1	0	0	0	0	1	0	0	0	5822	1493	52	5	343	5	FCHSD2	11	72553697	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	2047654	72553697	62452819	1137	51026											
ARHGEF17	9828	broad.mit.edu	37	chr11	73021299	73021300	+	Missense_Mutation	DNP	CC	TT	TT																															cacactcaaggacttgacagCcactctgcggagagcaaagt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:73021299_73021300CC>TT	uc001otu.2	+	1	1637_1638	c.1616_1617CC>TT	c.(1615-1617)GCC>GTT	p.A539V		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	539					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GACTTGACAGCCACTCTGCGGA	0.639													12	42					0	0	0	0	TT	73021300	TT	TT	73021299	3	4	276	1	0	0	0	0	1	0	0	0	900	739	26	4	1618	4	ARHGEF17	11	73021299	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	467602	73021299	61985217	1138	51027											
ARHGEF17	9828	broad.mit.edu	37	chr11	73021729	73021730	+	Missense_Mutation	DNP	CC	TT	TT																															gcccagacgaaccaccatggCcctgggactgaggacagtct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:73021729_73021730CC>TT	uc001otu.2	+	1	2067_2068	c.2046_2047CC>TT	c.(2044-2049)GGCCCT>GGTTCT	p.P683S		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	683					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						ACCACCATGGCCCTGGGACTGA	0.658													12	44					0	0	0	0	TT	73021730	TT	TT	73021729	3	4	276	1	0	0	0	0	1	0	0	0	900	726	26	4	2048	4	ARHGEF17	11	73021729	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	430	73021729	61984787	1139	51028											
C2CD3	26005	broad.mit.edu	37	chr11	73789715	73789715	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catgagctccaggccatgagGtaggcccccgtcttctggta	7	9	12	13	1	2	2	0	2	2	0	3	2	3	2	4	4	1	3	4	4	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:73789715G>A	uc001ouu.2	-	23	4275	c.4048C>T	c.(4048-4050)CCT>TCT	p.P1350S	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1350						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					AGGCCATGAGGTAGGCCCCCG	0.453													21	95					0	0	0	0	A	73789715	A	A	73789715	3	1	276	1	0	0	0	0	1	0	0	0	2164	1261	44	4	1879	4	C2CD3	11	73789715	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	767986	73789715	61216801	1140	51029											
GAB2	9846	broad.mit.edu	37	chr11	77937683	77937683	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggggagctatggctgagtcCccaggagtggccactgtcat	7	8	16	10	0	1	1	1	1	0	0	2	3	2	3	3	5	1	2	3	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:77937683C>T	uc001ozh.2	-	4	1035	c.1035G>A	c.(1033-1035)GGG>GGA	p.G345G	GAB2_uc001ozg.2_Silent_p.G307G	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	345					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TGGCTGAGTCCCCAGGAGTGG	0.567													11	80					0	0	0	0	T	77937683	T	T	77937683	2	4	276	1	0	0	0	0	0	0	0	1	6183	610	22	4		4	GAB2	11	77937683	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4147968	77937683	57068833	1141	51030											
SYTL2	54843	broad.mit.edu	37	chr11	85445671	85445671	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttcctggctttggggattGgagccttgatttgggaccca	5	14	13	9	0	1	1	0	1	1	0	2	4	2	4	3	5	1	1	3	5	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:85445671G>A	uc010rth.1	-	6	974	c.698C>T	c.(697-699)CCA>CTA	p.P233L	SYTL2_uc010rtg.1_Missense_Mutation_p.P234L|SYTL2_uc010rti.1_Missense_Mutation_p.P233L|SYTL2_uc010rtj.1_Missense_Mutation_p.P185L|SYTL2_uc001pbf.3_Missense_Mutation_p.P233L|SYTL2_uc010rtf.1_Missense_Mutation_p.P91L	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	233					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TTTGGGGATTGGAGCCTTGAT	0.408													17	70					0	0	0	0	A	85445671	A	A	85445671	3	1	276	1	0	0	0	0	1	0	0	0	15549	1348	47	4	4639	4	SYTL2	11	85445671	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7507988	85445671	49560845	1142	51031											
GRM5	2915	broad.mit.edu	37	chr11	88780752	88780752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agccgaatgccagcaggagtCccttatctcacagcccagtg	10	7	10	14	1	1	0	1	0	1	0	3	2	2	1	4	1	4	1	4	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:88780752C>T	uc001pcq.2	-	1	489	c.289G>A	c.(289-291)GAC>AAC	p.D97N	GRM5_uc009yvm.2_Missense_Mutation_p.D97N|GRM5_uc009yvn.1_Missense_Mutation_p.D97N	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	97	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CAGCAGGAGTCCCTTATCTCA	0.512													9	26					0	0	0	0	T	88780752	T	T	88780752	3	4	276	1	0	0	0	0	1	0	0	0	6839	855	30	2	3385	2	GRM5	11	88780752	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3335081	88780752	46225764	1143	51032											
TYR	7299	broad.mit.edu	37	chr11	88911532	88911533	+	Nonsense_Mutation	DNP	CC	AT	AT																															aaggacaaattttttgcctaCctcactttagcaaagcatac																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:88911532_88911533CC>AT	uc001pcs.2	+	1	493_494	c.411_412CC>AT	c.(409-414)TACCTC>TAATTC	p.137_138YL>*F		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	137_138	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TTTTTGCCTACCTCACTTTAGC	0.441									Oculocutaneous_Albinism				24	194					0	0	0	0	AT	88911533	AT	AT	88911532	4	1	276	1	0	0	0	0	0	1	0	0	16881	518	18	4	413	4	TYR	11	88911532	Nonsense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	130780	88911532	46094984	1144	51033											
NAALAD2	10003	broad.mit.edu	37	chr11	89902144	89902144	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcattgcttatatcaactcGgattcatctatagaaggtaa	14	13	7	7	1	3	1	2	0	1	1	4	2	3	2	0	2	3	3	0	2	7	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:89902144G>C	uc001pdf.3	+	12	1435	c.1326G>C	c.(1324-1326)TCG>TCC	p.S442S	NAALAD2_uc009yvx.2_Silent_p.S409S|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	442	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				ATATCAACTCGGATTCATCTA	0.294													8	73					0	0	0	0	C	89902144	C	C	89902144	2	2	276	1	0	0	0	0	0	0	0	1	10181	1103	39	3		3	NAALAD2	11	89902144	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	990612	89902144	45104372	1145	51034											
FAT3	120114	broad.mit.edu	37	chr11	92624018	92624018	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacccattccccaacgaaacGgatttggtgggcccgcctgc	8	7	10	16	3	0	0	0	0	0	0	1	2	1	1	5	3	3	0	5	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:92624018G>A	uc001pdj.3	+	25	13430	c.13413G>A	c.(13411-13413)ACG>ACA	p.T4471T	FAT3_uc001pdi.3_Silent_p.T943T	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4503	Pro-rich.|Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCAACGAAACGGATTTGGTGG	0.582										TCGA Ovarian(4;0.039)			15	32					0	0	0	0	A	92624018	A	A	92624018	2	1	276	1	0	0	0	0	0	0	0	1	5723	1103	39	1		1	FAT3	11	92624018	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2721874	92624018	42382498	1146	51035											
GPR83	10888	broad.mit.edu	37	chr11	94129658	94129658	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgacatggcacatgcccttCccaaatatccatgtgctgtt	9	12	7	13	0	0	1	0	1	0	0	2	1	2	1	3	1	2	3	3	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:94129658C>T	uc001pet.2	-	2	592	c.420G>A	c.(418-420)GGG>GGA	p.G140G		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	140	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ACATGCCCTTCCCAAATATCC	0.547													18	37					0	0	0	0	T	94129658	T	T	94129658	2	4	276	1	0	0	0	0	0	0	0	1	6751	842	30	2		2	GPR83	11	94129658	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1505640	94129658	40876858	1147	51036											
ANKRD49	54851	broad.mit.edu	37	chr11	94230098	94230098	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccaagcagattgcttctttGggctgctgaaaaaaatcggg	11	10	11	9	1	1	2	0	1	1	1	2	2	1	2	1	2	3	4	1	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:94230098G>A	uc001pew.2	+	2	378	c.239G>A	c.(238-240)TGG>TAG	p.W80*	ANKRD49_uc001pex.2_Nonsense_Mutation_p.W80*|ANKRD49_uc001pey.2_5'Flank	NM_017704	NP_060174	Q8WVL7	ANR49_HUMAN	fetal globin inducing factor	80	ANK 1.				positive regulation of transcription, DNA-dependent					central_nervous_system(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TTGCTTCTTTGGGCTGCTGAA	0.393													27	109					0	0	0	0	A	94230098	A	A	94230098	4	1	276	1	0	0	0	0	0	1	0	0	675	1357	47	4	241	4	ANKRD49	11	94230098	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	100440	94230098	40776418	1148	51037											
KDM4DL	390245	broad.mit.edu	37	chr11	94759406	94759406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcctggccagggagctcttcCcagacatttctcggggctgt	5	10	13	13	1	2	1	0	0	2	1	4	2	3	2	3	4	1	2	3	4	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:94759406C>T	uc010ruf.1	+	1	985	c.685C>T	c.(685-687)CCA>TCA	p.P229S		NM_001161630	NP_001155102	B2RXH2	KD4DL_HUMAN	lysine (K)-specific demethylase 4D-like	229	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GGAGCTCTTCCCAGACATTTC	0.552													12	42					0	0	0	0	T	94759406	T	T	94759406	3	4	276	1	0	0	0	0	1	0	0	0	8171	623	22	4	687	4	KDM4DL	11	94759406	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	529308	94759406	40247110	1149	51038											
KDM4DL	390245	broad.mit.edu	37	chr11	94759491	94759491	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctcaaggaaaatgggattcCcttcaattgcatgactcagg	12	11	9	9	0	3	1	3	1	1	0	5	3	4	3	1	3	1	1	1	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:94759491C>T	uc010ruf.1	+	1	1070	c.770C>T	c.(769-771)CCC>CTC	p.P257L		NM_001161630	NP_001155102	B2RXH2	KD4DL_HUMAN	lysine (K)-specific demethylase 4D-like	257	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AATGGGATTCCCTTCAATTGC	0.547													9	42					0	0	0	0	T	94759491	T	T	94759491	3	4	276	1	0	0	0	0	1	0	0	0	8171	623	22	4	772	4	KDM4DL	11	94759491	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	85	94759491	40247025	1150	51039											
MMP27	64066	broad.mit.edu	37	chr11	102567462	102567462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagtgggtattttctgggatCcagggagacataatttggga	11	12	14	4	0	1	1	0	0	1	1	2	4	2	3	1	4	0	1	1	4	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:102567462C>T	uc001phd.1	-	5	747	c.724G>A	c.(724-726)GAT>AAT	p.D242N		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	242					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		TTTCTGGGATCCAGGGAGACA	0.403													10	44					0	0	0	0	T	102567462	T	T	102567462	3	4	276	1	0	0	0	0	1	0	0	0	9717	855	30	2	841	2	MMP27	11	102567462	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	7807971	102567462	32439054	1151	51040											
MMP13	4322	broad.mit.edu	37	chr11	102825319	102825319	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttcagaatgagtcatatcagGggtgtaattcacaattctat	13	14	8	6	0	5	2	4	1	1	1	5	2	5	2	0	2	0	1	0	2	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:102825319G>A	uc001phl.2	-	3	407	c.379C>T	c.(379-381)CCT>TCT	p.P127S		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	127					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GTCATATCAGGGGTGTAATTC	0.343													23	61					0	0	0	0	A	102825319	A	A	102825319	3	1	276	1	0	0	0	0	1	0	0	0	9705	1232	43	4	1068	4	MMP13	11	102825319	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	257857	102825319	32181197	1152	51041											
DYNC2H1	79659	broad.mit.edu	37	chr11	103006531	103006531	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgaagagattcatcggcattCcaaatcagtttaagggagtg	13	11	11	6	1	2	2	2	1	0	1	4	4	3	3	1	2	0	2	1	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:103006531C>T	uc001pho.2	+	17	2572	c.2428C>T	c.(2428-2430)CCA>TCA	p.P810S	DYNC2H1_uc001phn.1_Missense_Mutation_p.P810S|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	810	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CATCGGCATTCCAAATCAGTT	0.358													6	39					0	0	0	0	T	103006531	T	T	103006531	3	4	276	1	0	0	0	0	1	0	0	0	4868	855	30	2	2494	2	DYNC2H1	11	103006531	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	181212	103006531	31999985	1153	51042											
CASP5	838	broad.mit.edu	37	chr11	104878062	104878062	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttttttttgtggttgtcttCtgtcagaaatagaaagactc	9	19	8	5	0	3	3	1	0	2	3	4	3	3	3	0	1	0	1	0	1	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:104878062C>T	uc010rva.1	-	3	214	c.182_splice	c.e3-1	p.K61_splice	CASP5_uc010ruz.1_Splice_Site_p.K74_splice|CASP5_uc010rvb.1_Splice_Site_p.E3_splice|CASP5_uc010rvc.1_Intron|CASP5_uc009yxh.2_Splice_Site|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor						apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		TGGTTGTCTTCTGTCAGAAAT	0.353													15	97					0	0	0	0	T	104878062	T	T	104878062	5	4	276	1	0	0	0	0	0	0	1	0	2686	927	32	2	1151	2	CASP5	11	104878062	Splice_Site	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1871531	104878062	30128454	1154	51043											
GRIA4	2893	broad.mit.edu	37	chr11	105789574	105789574	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaattgccattgtccctgAtggaaaatatggagcaaggg	14	10	11	6	0	0	1	0	1	0	0	1	3	1	3	2	3	2	1	2	3	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:105789574A>T	uc001pix.2	+	11	1852	c.1406A>T	c.(1405-1407)GAT>GTT	p.D469V	GRIA4_uc001piw.2_Missense_Mutation_p.D469V	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	469	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATTGTCCCTGATGGAAAATAT	0.358													14	34					0	0	0	0	T	105789574	T	T	105789574	3	4	276	1	0	0	0	0	1	0	0	0	6809	333	12	5	1481	5	GRIA4	11	105789574	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	911512	105789574	29216942	1155	51044											
NPAT	4863	broad.mit.edu	37	chr11	108031734	108031734	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggtgctccttgaagatgctCtaaactgttgtgtgttatct	7	17	10	7	0	2	2	0	1	2	1	3	2	3	2	1	1	3	4	1	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:108031734C>T	uc001pjz.3	-	17	4181	c.4079G>A	c.(4078-4080)AGA>AAA	p.R1360K	NPAT_uc010rvv.1_Missense_Mutation_p.R416K	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	1360					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TGAAGATGCTCTAAACTGTTG	0.403													21	91					0	0	0	0	T	108031734	T	T	108031734	3	4	276	1	0	0	0	0	1	0	0	0	10620	913	32	2	212	2	NPAT	11	108031734	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2242160	108031734	26974782	1156	51045											
C11orf65	160140	broad.mit.edu	37	chr11	108276232	108276232	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctcttcagtttagagaaatGgaattcactttcctttttgt	9	19	6	7	0	3	1	2	0	1	1	5	3	4	2	1	1	0	1	1	1	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:108276232G>A	uc001pkh.2	-	6	554	c.484C>T	c.(484-486)CAT>TAT	p.H162Y	C11orf65_uc010rvx.1_Missense_Mutation_p.H113Y|C11orf65_uc009yxu.1_RNA	NM_152587	NP_689800	Q8NCR3	CK065_HUMAN	hypothetical protein LOC160140	162										ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		TTAGAGAAATGGAATTCACTT	0.318													14	69					0	0	0	0	A	108276232	A	A	108276232	3	1	276	1	0	0	0	0	1	0	0	0	1661	1348	47	4	473	4	C11orf65	11	108276232	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	244498	108276232	26730284	1157	51046											
ZW10	9183	broad.mit.edu	37	chr11	113631062	113631062	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttaaatcaaagcattttctgGattttaataacttcaagcat	15	16	4	6	0	3	0	2	0	1	0	3	1	3	1	0	1	3	2	0	1	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:113631062G>A	uc001poe.2	-	5	486	c.449C>T	c.(448-450)TCC>TTC	p.S150F	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	150	Interaction with RINT1.				cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		GCATTTTCTGGATTTTAATAA	0.353													17	65					0	0	0	0	A	113631062	A	A	113631062	3	1	276	1	0	0	0	0	1	0	0	0	18314	1174	41	2	1938	2	ZW10	11	113631062	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5354830	113631062	21375454	1158	51047											
FAM55A	120400	broad.mit.edu	37	chr11	114392934	114392934	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcactttagtggctgggcttCttaggaacagtctttcaata	9	15	9	8	0	4	0	2	0	2	0	4	1	4	1	0	3	1	2	0	3	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:114392934C>G	uc001ppa.2	-	6	1391	c.974G>C	c.(973-975)AGA>ACA	p.R325T	FAM55A_uc010rxd.1_Missense_Mutation_p.R174T	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	467						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		GGCTGGGCTTCTTAGGAACAG	0.418													44	72					0	0	0	0	G	114392934	G	G	114392934	3	3	276	1	0	0	0	0	1	0	0	0	5616	913	32	2	247	2	FAM55A	11	114392934	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	761872	114392934	20613582	1159	51048											
FAM55B	120406	broad.mit.edu	37	chr11	114568989	114568989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcacagccaccatcctcaacCctcaagatacgtactgcagg	12	6	7	16	1	2	1	2	0	0	1	3	1	3	1	4	1	5	3	4	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:114568989C>T	uc009yyy.2	+	3	453	c.355C>T	c.(355-357)CCT>TCT	p.P119S		NM_182495	NP_872301	Q96DL1	FA55B_HUMAN	hypothetical protein LOC120406	119						integral to membrane				ovary(1)	1						CATCCTCAACCCTCAAGATAC	0.547													18	48					0	0	0	0	T	114568989	T	T	114568989	3	4	276	1	0	0	0	0	1	0	0	0	5617	623	22	4	365	4	FAM55B	11	114568989	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	176055	114568989	20437527	1160	51049											
BUD13	84811	broad.mit.edu	37	chr11	116631629	116631629	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggactttgtttatgccgtGgagaagaaaggtctgaatca	11	12	12	6	1	2	3	1	1	1	2	2	5	2	4	1	3	1	1	1	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:116631629G>A	uc001ppn.2	-	5	1110	c.1076C>T	c.(1075-1077)CCA>CTA	p.P359L	BUD13_uc001ppo.2_Missense_Mutation_p.P225L|BUD13_uc009yzc.2_Missense_Mutation_p.P359L	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	359										large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		TTTATGCCGTGGAGAAGAAAG	0.478													14	65					0	0	0	0	A	116631629	A	A	116631629	3	1	276	1	0	0	0	0	1	0	0	0	1578	1348	47	4	807	4	BUD13	11	116631629	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2062640	116631629	18374887	1161	51050											
DSCAML1	57453	broad.mit.edu	37	chr11	117301448	117301448	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagcactcactcttgttggcCcggtgagggatgggcacagc	7	8	15	11	1	2	1	1	1	1	0	2	3	2	2	1	4	2	3	1	4	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:117301448C>T	uc001prh.1	-	32	5858	c.5856G>A	c.(5854-5856)CGG>CGA	p.R1952R		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1892	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TCTTGTTGGCCCGGTGAGGGA	0.667													14	98					0	0	0	0	T	117301448	T	T	117301448	2	4	276	1	0	0	0	0	0	0	0	1	4791	610	22	4		4	DSCAML1	11	117301448	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	669819	117301448	17705068	1162	51051											
MPZL3	196264	broad.mit.edu	37	chr11	118111019	118111019	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacttgaaagtgcatttcaaCttgatcttttctccaacata	12	15	5	9	0	3	2	1	2	2	0	4	3	3	2	1	0	3	1	1	0	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:118111019C>T	uc001psm.2	-	2	149	c.147G>A	c.(145-147)AAG>AAA	p.K49K	MPZL3_uc010rxy.1_Silent_p.K37K|MPZL3_uc010rxz.1_RNA|MPZL3_uc009yzy.2_Intron	NM_198275	NP_938016	Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3 precursor	49	Ig-like V-type.				cell adhesion	integral to membrane					0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TGCATTTCAACTTGATCTTTT	0.423													21	55					0	0	0	0	T	118111019	T	T	118111019	2	4	276	1	0	0	0	0	0	0	0	1	9804	564	20	4		4	MPZL3	11	118111019	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	809571	118111019	16895497	1163	51052											
MPZL2	10205	broad.mit.edu	37	chr11	118133656	118133656	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctacttacaaactgctcaGgtcccccgtctagaggacga	11	9	8	13	2	3	1	1	0	2	1	4	3	4	2	2	2	4	1	2	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:118133656G>A	uc001psn.2	-	2	356	c.215C>T	c.(214-216)CCT>CTT	p.P72L	MPZL2_uc001pso.2_Missense_Mutation_p.P72L|MPZL2_uc001psp.1_Missense_Mutation_p.P72L	NM_005797	NP_005788	O60487	MPZL2_HUMAN	myelin protein zero-like 2 precursor	72	Extracellular (Potential).|Ig-like V-type.				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				skin(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		AAACTGCTCAGGTCCCCCGTC	0.438													73	158					0	0	0	0	A	118133656	A	A	118133656	3	1	276	1	0	0	0	0	1	0	0	0	9803	1000	35	4	448	4	MPZL2	11	118133656	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	22637	118133656	16872860	1164	51053											
MLL	4297	broad.mit.edu	37	chr11	118390382	118390382	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctccatgatgcagttgtgttCctcattgagcagctgtctgg	6	14	11	10	0	2	2	1	2	1	0	4	2	4	2	2	1	3	5	2	1	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:118390382C>T	uc001pta.2	+	32	11210	c.11187C>T	c.(11185-11187)TTC>TTT	p.F3729F	MLL_uc001ptb.2_Silent_p.F3732F	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3729	FYR C-terminal.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CAGTTGTGTTCCTCATTGAGC	0.512			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								64	103					0	0	0	0	T	118390382	T	T	118390382	2	4	276	1	0	0	0	0	0	0	0	1	9673	854	30	2		2	MLL	11	118390382	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	256726	118390382	16616134	1165	51054											
HINFP	25988	broad.mit.edu	37	chr11	119005131	119005131	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaggggagcctcccccaGcccctgagccaccttcaggg	6	4	11	20	0	1	1	1	1	0	0	2	2	2	2	9	3	3	0	9	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:119005131G>A	uc001pvp.2	+	11	1666	c.1477G>A	c.(1477-1479)GCC>ACC	p.A493T	HINFP_uc001pvq.2_Missense_Mutation_p.A493T|HINFP_uc001pvr.2_Missense_Mutation_p.A246T	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	493	Interaction with NPAT.				DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GCCTCCCCCAGCCCCTGAGCC	0.567											OREG0021397	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	56					0	0	0	0	A	119005131	A	A	119005131	3	1	276	1	0	0	0	0	1	0	0	0	7149	971	34	4	1511	4	HINFP	11	119005131	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	614749	119005131	16001385	1166	51055											
NLRX1	79671	broad.mit.edu	37	chr11	119044583	119044583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtcatccctgggccctgccCcagcctccctgtgccaactt	4	10	8	19	0	1	0	1	0	0	0	3	0	3	0	7	1	4	0	7	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:119044583C>T	uc001pvu.2	+	5	840	c.625C>T	c.(625-627)CCA>TCA	p.P209S	NLRX1_uc010rzc.1_Missense_Mutation_p.P31S|NLRX1_uc001pvv.2_Missense_Mutation_p.P209S|NLRX1_uc001pvw.2_Missense_Mutation_p.P209S|NLRX1_uc001pvx.2_Missense_Mutation_p.P209S	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	209	Required for interaction with MAVS.|NACHT.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGGCCCTGCCCCAGCCTCCCT	0.642													17	28					0	0	0	0	T	119044583	T	T	119044583	3	4	276	1	0	0	0	0	1	0	0	0	10539	623	22	4	639	4	NLRX1	11	119044583	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	39452	119044583	15961933	1167	51056											
NLRX1	79671	broad.mit.edu	37	chr11	119052950	119052950	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctgcccagctggaccgcaaCcggcagctgcaggagctgaa	9	4	14	14	2	0	1	0	1	0	0	0	3	0	3	3	3	6	7	3	3	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:119052950C>T	uc001pvu.2	+	9	2717	c.2502C>T	c.(2500-2502)AAC>AAT	p.N834N	NLRX1_uc001pvv.2_Silent_p.N834N|NLRX1_uc001pvw.2_Silent_p.N834N|NLRX1_uc001pvx.2_Silent_p.N834N	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	834	LRR 5.|Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGGACCGCAACCGGCAGCTGC	0.682													15	67					0	0	0	0	T	119052950	T	T	119052950	2	4	276	1	0	0	0	0	0	0	0	1	10539	506	18	4		4	NLRX1	11	119052950	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	8367	119052950	15953566	1168	51057											
MCAM	4162	broad.mit.edu	37	chr11	119183335	119183335	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cattcccacgggctccacttCcagccacactttttctgtcg	6	12	6	17	2	1	0	0	0	1	0	5	0	4	0	4	1	1	1	4	1	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:119183335C>T	uc001pwf.2	-	7	792	c.763G>A	c.(763-765)GAA>AAA	p.E255K	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	255	Ig-like C2-type 1.|Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane		p.E255K(1)		ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		GGCTCCACTTCCAGCCACACT	0.577													23	144					0	0	0	0	T	119183335	T	T	119183335	3	4	276	1	0	0	0	0	1	0	0	0	9421	864	30	2	1217	2	MCAM	11	119183335	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	130385	119183335	15823181	1169	51058											
ARHGEF12	23365	broad.mit.edu	37	chr11	120347993	120347993	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atccacaaagccaattccatTaccacagtcaacacctggcg	14	7	5	15	1	1	0	1	0	0	0	3	0	3	0	5	1	3	0	5	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:120347993T>A	uc001pxl.1	+	35	3438	c.3431T>A	c.(3430-3432)TTA>TAA	p.L1144*	ARHGEF12_uc009zat.2_Nonsense_Mutation_p.L1125*|ARHGEF12_uc010rzn.1_Nonsense_Mutation_p.L1041*|ARHGEF12_uc009zau.1_Nonsense_Mutation_p.L1041*	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1144					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CCAATTCCATTACCACAGTCA	0.398			T	MLL	AML								20	29					0	0	0	0	A	120347993	A	A	120347993	4	1	276	1	0	0	0	0	0	1	0	0	897	1764	61	5	3569	5	ARHGEF12	11	120347993	Nonsense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1164658	120347993	14658523	1170	51059											
TECTA	7007	broad.mit.edu	37	chr11	121008716	121008716	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atcgtgatccaccgagcttaCaagcacactgtgctggtgag	10	9	11	11	2	0	2	0	2	0	0	2	3	1	2	2	1	4	3	2	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:121008716C>A	uc010rzo.1	+	10	3528	c.3528C>A	c.(3526-3528)TAC>TAA	p.Y1176*		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1176	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ACCGAGCTTACAAGCACACTG	0.577													7	29					8.12818e-05	8.22877e-05	1	0	A	121008716	A	A	121008716	4	1	276	1	0	0	0	0	0	1	0	0	15813	489	17	4	3566	4	TECTA	11	121008716	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	660723	121008716	13997800	1171	51060											
TMEM225	338661	broad.mit.edu	37	chr11	123755988	123755988	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agggcaacacatcatccaagGactgtggttcatcttggctc	10	10	10	11	0	3	0	2	0	1	0	5	1	4	1	1	4	1	3	1	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:123755988G>T	uc001pzi.2	-	1	353	c.145C>A	c.(145-147)CCT>ACT	p.P49T		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	49						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						ATCATCCAAGGACTGTGGTTC	0.463													31	73					9.17885e-22	9.53999e-22	1	0	T	123755988	T	T	123755988	3	4	276	1	0	0	0	0	1	0	0	0	16213	1174	41	2	548	2	TMEM225	11	123755988	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2747272	123755988	11250528	1172	51061											
OR10G4	390264	broad.mit.edu	37	chr11	123887148	123887148	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccctgttgtgtacaccctGagaaacaaggaggtgaagaa	15	7	11	8	0	0	3	0	2	0	2	0	5	0	4	2	2	3	2	2	2	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:123887148G>A	uc010sac.1	+	1	867	c.867G>A	c.(865-867)CTG>CTA	p.L289L		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TGTACACCCTGAGAAACAAGG	0.438													11	93					0	0	0	0	A	123887148	A	A	123887148	2	1	276	1	0	0	0	0	0	0	0	1	10955	1277	45	2		2	OR10G4	11	123887148	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	131160	123887148	11119368	1173	51062											
OR10G9	219870	broad.mit.edu	37	chr11	123894355	123894355	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctcgggctgctttctcctGatagtgctgtcttatgtgtc	3	16	11	11	1	2	1	0	1	2	0	5	1	2	1	2	1	2	3	2	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:123894355G>A	uc010sad.1	+	1	636	c.636G>A	c.(634-636)CTG>CTA	p.L212L		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GCTTTCTCCTGATAGTGCTGT	0.567													45	94					0	0	0	0	A	123894355	A	A	123894355	2	1	276	1	0	0	0	0	0	0	0	1	10958	1277	45	2		2	OR10G9	11	123894355	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7207	123894355	11112161	1174	51063											
OR10G8	219869	broad.mit.edu	37	chr11	123900446	123900446	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tacgtgctcactgtgctgggGaacctcctcatcctgctggt	5	12	11	13	1	2	0	2	0	0	0	4	1	4	1	3	3	5	3	3	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:123900446G>A	uc001pzp.1	+	1	117	c.117G>A	c.(115-117)GGG>GGA	p.G39G		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTGTGCTGGGGAACCTCCTCA	0.562													49	111					0	0	0	0	A	123900446	A	A	123900446	2	1	276	1	0	0	0	0	0	0	0	1	10957	1161	41	2		2	OR10G8	11	123900446	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6091	123900446	11106070	1175	51064											
OR10G8	219869	broad.mit.edu	37	chr11	123901244	123901244	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttgaagctgaaagacaaagtAgcacattctcagagcaaata	18	8	8	7	0	1	4	1	2	1	2	2	4	1	4	0	0	3	4	0	0	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:123901244A>T	uc001pzp.1	+	1	915	c.915A>T	c.(913-915)GTA>GTT	p.V305V		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AAGACAAAGTAGCACATTCTC	0.284													10	63					0	0	0	0	T	123901244	T	T	123901244	2	4	276	1	0	0	0	0	0	0	0	1	10957	407	15	5		5	OR10G8	11	123901244	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	798	123901244	11105272	1176	51065											
OR8D1	283159	broad.mit.edu	37	chr11	124180597	124180597	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggaagaggggcagctggagCtctgcttgctgtgttaaacc	9	9	15	8	0	1	1	0	0	1	1	1	3	1	3	1	4	5	6	1	4	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:124180597C>A	uc010sag.1	-	1	66	c.66G>T	c.(64-66)GAG>GAT	p.E22D		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GCAGCTGGAGCTCTGCTTGCT	0.453													22	137					1.66031e-10	1.69985e-10	1	0	A	124180597	A	A	124180597	3	1	276	1	0	0	0	0	1	0	0	0	11285	796	28	4	863	4	OR8D1	11	124180597	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	279353	124180597	10825919	1177	51066											
PANX3	116337	broad.mit.edu	37	chr11	124487183	124487183	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctgcaggccctcccctactCcctgctggccctggccttgc	2	9	9	21	0	0	0	0	0	0	0	2	0	2	0	7	3	4	2	7	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:124487183C>T	uc001qah.2	+	3	338	c.338C>T	c.(337-339)TCC>TTC	p.S113F		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	113	Extracellular (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CTCCCCTACTCCCTGCTGGCC	0.647													5	29					0	0	0	0	T	124487183	T	T	124487183	3	4	276	1	0	0	0	0	1	0	0	0	11476	855	30	2	348	2	PANX3	11	124487183	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	306586	124487183	10519333	1178	51067											
CCDC15	80071	broad.mit.edu	37	chr11	124829770	124829770	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acacacttaacttccaaaagGacaagtgtttttccaaacaa	17	10	4	10	0	0	0	0	0	0	0	2	1	2	1	2	1	2	1	2	1	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:124829770G>A	uc001qbm.3	+	4	646	c.387G>A	c.(385-387)AGG>AGA	p.R129R		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	129						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CTTCCAAAAGGACAAGTGTTT	0.428													5	21					0	0	0	0	A	124829770	A	A	124829770	2	1	276	1	0	0	0	0	0	0	0	1	2796	1165	41	2		2	CCDC15	11	124829770	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	342587	124829770	10176746	1179	51068											
PKNOX2	63876	broad.mit.edu	37	chr11	125267805	125267805	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggtcctgagaatccacctGctggagctggagaaagtcaa	12	7	12	10	0	1	2	1	1	0	2	3	5	3	3	3	3	2	2	3	3	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:125267805G>T	uc001qbu.2	+	7	749	c.435G>T	c.(433-435)CTG>CTT	p.L145L	PKNOX2_uc010saz.1_Silent_p.L116L|PKNOX2_uc010sba.1_Silent_p.L116L|PKNOX2_uc010sbb.1_Silent_p.L81L	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	145						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		GAATCCACCTGCTGGAGCTGG	0.532													8	74					0.000157383	0.000159077	1	0	T	125267805	T	T	125267805	2	4	276	1	0	0	0	0	0	0	0	1	12038	1306	46	4		4	PKNOX2	11	125267805	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	438035	125267805	9738711	1180	51069											
HYLS1	219844	broad.mit.edu	37	chr11	125769334	125769334	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaacgaatgttggcagctgCtacagcttttacccacatct	11	11	8	11	1	1	1	0	0	1	1	1	2	1	1	1	1	6	5	1	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:125769334C>T	uc009zbv.2	+	4	605	c.71C>T	c.(70-72)GCT>GTT	p.A24V	HYLS1_uc001qcx.3_Missense_Mutation_p.A24V|PUS3_uc001qcy.2_Intron	NM_145014	NP_659451	Q96M11	HYLS1_HUMAN	hydrolethalus syndrome 1	24						centrosome|nucleus				upper_aerodigestive_tract(1)	1	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		TTGGCAGCTGCTACAGCTTTT	0.473													8	87					0	0	0	0	T	125769334	T	T	125769334	3	4	276	1	0	0	0	0	1	0	0	0	7508	797	28	4	73	4	HYLS1	11	125769334	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	501529	125769334	9237182	1181	51070											
ETS1	2113	broad.mit.edu	37	chr11	128426323	128426323	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttcataagtgttgctaggtCcttgcctctgtgcaagaaaa	10	13	9	9	0	2	1	1	0	1	1	3	1	3	1	2	1	3	3	2	1	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:128426323C>T	uc001qej.2	-	3	162	c.77G>A	c.(76-78)GGA>GAA	p.G26E		NM_001143820	NP_001137292	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	Error:Variant_position_missing_in_P14921_after_alignment					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		GTTGCTAGGTCCTTGCCTCTG	0.393													5	22					0	0	0	0	T	128426323	T	T	128426323	3	4	276	1	0	0	0	0	1	0	0	0	5299	855	30	2	1498	2	ETS1	11	128426323	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2656989	128426323	6580193	1182	51071											
FLI1	2313	broad.mit.edu	37	chr11	128628073	128628073	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgtacggagcggcagccCatctccccaaggccgacatg	9	4	12	16	4	1	0	0	0	1	0	2	2	1	1	4	3	4	2	4	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:128628073C>T	uc010sbu.1	+	2	423	c.82C>T	c.(82-84)CAT>TAT	p.H28Y	FLI1_uc010sbt.1_5'UTR|FLI1_uc010sbv.1_5'UTR|FLI1_uc009zci.2_5'UTR|FLI1_uc001qen.2_5'UTR	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	28					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		AGCGGCAGCCCATCTCCCCAA	0.622			T	EWSR1	Ewing sarcoma								3	12					0	0	0	0	T	128628073	T	T	128628073	3	4	276	1	0	0	0	0	1	0	0	0	5956	594	21	4	88	4	FLI1	11	128628073	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	201750	128628073	6378443	1183	51072											
FLI1	2313	broad.mit.edu	37	chr11	128638162	128638162	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgagaggagagtcatcgtccCcgcaggtaattcgagaacca	12	6	12	11	4	1	3	1	0	0	3	4	6	2	3	3	2	1	2	3	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:128638162C>T	uc010sbu.1	+	3	721	c.380C>T	c.(379-381)CCC>CTC	p.P127L	FLI1_uc010sbt.1_Intron|FLI1_uc010sbv.1_Missense_Mutation_p.P94L|FLI1_uc009zci.2_Missense_Mutation_p.P61L|FLI1_uc001qen.2_Missense_Mutation_p.P94L	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	127	PNT.				hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GTCATCGTCCCCGCAGGTAAT	0.557			T	EWSR1	Ewing sarcoma								6	28					0	0	0	0	T	128638162	T	T	128638162	3	4	276	1	0	0	0	0	1	0	0	0	5956	623	22	4	390	4	FLI1	11	128638162	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	10089	128638162	6368354	1184	51073											
PRDM10	56980	broad.mit.edu	37	chr11	129802048	129802048	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcgctggtgatttccaggcgGataaattttggaggacgccc	8	11	13	9	3	0	1	0	1	0	0	2	4	1	4	2	5	0	1	2	5	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:129802048G>A	uc001qfm.2	-	10	1468	c.1236C>T	c.(1234-1236)ATC>ATT	p.I412I	PRDM10_uc001qfj.2_Silent_p.I326I|PRDM10_uc001qfk.2_Silent_p.I326I|PRDM10_uc001qfl.2_Silent_p.I326I|PRDM10_uc010sbx.1_Silent_p.I326I|PRDM10_uc001qfn.2_Silent_p.I412I|PRDM10_uc009zct.1_Silent_p.I444I	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TTTCCAGGCGGATAAATTTTG	0.577													18	71					0	0	0	0	A	129802048	A	A	129802048	2	1	276	1	0	0	0	0	0	0	0	1	12513	1164	41	2		2	PRDM10	11	129802048	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1163886	129802048	5204468	1185	51074											
NTM	50863	broad.mit.edu	37	chr11	132016247	132016247	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcctctatgctgggaatgAcaagtggtgcctggatcctc	8	11	11	11	0	1	1	0	1	1	0	4	3	3	3	3	3	2	1	3	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:132016247A>T	uc001qgp.2	+	2	903	c.239A>T	c.(238-240)GAC>GTC	p.D80V	NTM_uc001qgm.2_Missense_Mutation_p.D80V|NTM_uc010sch.1_Missense_Mutation_p.D71V|NTM_uc010sci.1_Missense_Mutation_p.D80V|NTM_uc010scj.1_Missense_Mutation_p.D39V|NTM_uc001qgo.2_Missense_Mutation_p.D80V|NTM_uc001qgq.2_Missense_Mutation_p.D80V	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	80	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						GCTGGGAATGACAAGTGGTGC	0.562													7	76					0	0	0	0	T	132016247	T	T	132016247	3	4	276	1	0	0	0	0	1	0	0	0	10753	275	10	5	331	5	NTM	11	132016247	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	2214199	132016247	2990269	1186	51075											
OPCML	4978	broad.mit.edu	37	chr11	132306111	132306111	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctttgttttcaatcctcattCcatccagaccagtggctaac	9	14	5	13	0	2	1	2	0	0	1	5	1	5	1	4	1	1	2	4	1	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:132306111C>T	uc001qgs.2	-	6	856	c.806G>A	c.(805-807)GGA>GAA	p.G269E	OPCML_uc001qgu.2_Missense_Mutation_p.G262E|OPCML_uc010sck.1_Missense_Mutation_p.G269E|OPCML_uc001qgt.2_Missense_Mutation_p.G268E|OPCML_uc010scl.1_Missense_Mutation_p.G228E	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	269	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		AATCCTCATTCCATCCAGACC	0.438													10	70					0	0	0	0	T	132306111	T	T	132306111	3	4	276	1	0	0	0	0	1	0	0	0	10928	855	30	2	239	2	OPCML	11	132306111	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	289864	132306111	2700405	1187	51076											
GLB1L2	89944	broad.mit.edu	37	chr11	134244922	134244922	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttacagttcacggaaaccccCcacctgggcaggaaccagta	12	6	9	14	1	1	0	1	0	0	0	1	2	1	2	5	3	3	3	5	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr11:134244922C>T	uc001qhp.2	+	19	2069	c.1881C>T	c.(1879-1881)CCC>CCT	p.P627P	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	627					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CGGAAACCCCCCACCTGGGCA	0.627													7	16					0	0	0	0	T	134244922	T	T	134244922	2	4	276	1	0	0	0	0	0	0	0	1	6466	610	22	4		4	GLB1L2	11	134244922	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1938811	134244922	761594	1188	51077											
CACNA2D4	93589	broad.mit.edu	37	chr12	2016673	2016673	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtcaacgttgggtctctctgGaagttctccacgaagacagc	9	10	11	11	2	4	1	1	0	3	1	6	3	4	2	1	2	2	2	1	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:2016673G>A	uc001qjp.2	-	6	945	c.714C>T	c.(712-714)TTC>TTT	p.F238F	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Silent_p.F238F	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	238	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GGTCTCTCTGGAAGTTCTCCA	0.453													4	23					0	0	0	0	A	2016673	A	A	2016673	2	1	276	1	0	0	0	0	0	0	0	1	2563	1165	41	2		2	CACNA2D4	12	2016673	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08		2016673	131835222	1189	51078											
CACNA1C	775	broad.mit.edu	37	chr12	2566793	2566793	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggggcaaacgctctcggaggGaaaggggccggatttgatgt	9	7	18	7	3	1	1	0	1	1	0	2	4	1	4	1	7	1	2	1	7	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:2566793G>A	uc009zdu.1	+	5	991	c.678G>A	c.(676-678)GGG>GGA	p.G226G	CACNA1C_uc009zdv.1_Silent_p.G226G|CACNA1C_uc001qkb.2_Silent_p.G226G|CACNA1C_uc001qkc.2_Silent_p.G226G|CACNA1C_uc001qke.2_Silent_p.G226G|CACNA1C_uc001qkf.2_Silent_p.G226G|CACNA1C_uc001qjz.2_Silent_p.G226G|CACNA1C_uc001qkd.2_Silent_p.G226G|CACNA1C_uc001qkg.2_Silent_p.G226G|CACNA1C_uc009zdw.1_Silent_p.G226G|CACNA1C_uc001qkh.2_Silent_p.G226G|CACNA1C_uc001qkl.2_Silent_p.G226G|CACNA1C_uc001qkn.2_Silent_p.G226G|CACNA1C_uc001qko.2_Silent_p.G226G|CACNA1C_uc001qkp.2_Silent_p.G226G|CACNA1C_uc001qkr.2_Silent_p.G226G|CACNA1C_uc001qku.2_Silent_p.G226G|CACNA1C_uc001qkq.2_Silent_p.G226G|CACNA1C_uc001qks.2_Silent_p.G226G|CACNA1C_uc001qkt.2_Silent_p.G226G|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_5'UTR|CACNA1C_uc001qkj.1_5'UTR|CACNA1C_uc001qkk.1_5'UTR|CACNA1C_uc001qkm.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	226	Extracellular (Potential).|I.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CTCTCGGAGGGAAAGGGGCCG	0.557													39	120					0	0	0	0	A	2566793	A	A	2566793	2	1	276	1	0	0	0	0	0	0	0	1	2552	1161	41	2		2	CACNA1C	12	2566793	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	550120	2566793	131285102	1190	51079											
VWF	7450	broad.mit.edu	37	chr12	6122811	6122811	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caatagggaacactgtcactCctagagttagcaaagagaca	16	7	9	9	0	1	2	1	0	0	2	2	4	2	3	1	1	2	2	1	1	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:6122811C>T	uc001qnn.1	-	32	5706	c.5456G>A	c.(5455-5457)AGA>AAA	p.R1819K	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1819	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CACTGTCACTCCTAGAGTTAG	0.507													17	47					0	0	0	0	T	6122811	T	T	6122811	3	4	276	1	0	0	0	0	1	0	0	0	17314	869	30	2	3069	2	VWF	12	6122811	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3556018	6122811	127729084	1191	51080											
CD4	920	broad.mit.edu	37	chr12	6909313	6909313	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcaaggccacaatgaaccgGggagtcccttttaggcactt	10	8	12	11	1	0	1	0	1	0	0	1	2	1	2	3	5	1	2	3	5	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:6909313G>A	uc001qqv.1	+	2	254	c.9G>A	c.(7-9)CGG>CGA	p.R3R	CD4_uc009zez.1_Silent_p.R3R|CD4_uc009zfa.1_Intron|CD4_uc009zfb.1_Intron|CD4_uc010sfj.1_Intron|CD4_uc009zfc.1_Intron|CD4_uc010sfk.1_Intron|CD4_uc010sfl.1_Intron	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	3					cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)				CAATGAACCGGGGAGTCCCTT	0.572													28	33					0	0	0	0	A	6909313	A	A	6909313	2	1	276	1	0	0	0	0	0	0	0	1	3029	1219	43	4		4	CD4	12	6909313	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	786502	6909313	126942582	1192	51081											
USP5	8078	broad.mit.edu	37	chr12	6965611	6965611	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caaccctgctcgaatccctcCctggtgaggcctggcccctc	5	8	9	19	1	0	1	0	1	0	0	4	2	2	1	6	3	2	1	6	3	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:6965611C>T	uc001qri.3	+	5	640	c.581C>T	c.(580-582)CCC>CTC	p.P194L	USP5_uc001qrh.3_Missense_Mutation_p.P194L	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	194					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						CGAATCCCTCCCTGGTGAGGC	0.627													11	66					0	0	0	0	T	6965611	T	T	6965611	3	4	276	1	0	0	0	0	1	0	0	0	17149	623	22	4	599	4	USP5	12	6965611	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	56298	6965611	126886284	1193	51082											
USP5	8078	broad.mit.edu	37	chr12	6973918	6973918	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacgggctgtggactggatCttcagtcacattgacgacct	9	10	12	10	2	3	1	2	1	1	0	3	5	3	3	1	3	1	1	1	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:6973918C>T	uc001qri.3	+	18	2336	c.2277C>T	c.(2275-2277)ATC>ATT	p.I759I	USP5_uc001qrh.3_Silent_p.I736I|TPI1_uc001qrk.2_5'Flank	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	759	UBA 2.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						TGGACTGGATCTTCAGTCACA	0.413													22	60					0	0	0	0	T	6973918	T	T	6973918	2	4	276	1	0	0	0	0	0	0	0	1	17149	903	32	2		2	USP5	12	6973918	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	8307	6973918	126877977	1194	51083											
C1S	716	broad.mit.edu	37	chr12	7171649	7171649	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cattggtggttacttctgctCctgccccccggaatatttcc	5	14	8	14	1	1	0	0	0	1	0	3	1	3	1	5	3	3	2	5	3	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:7171649C>T	uc001qsj.2	+	8	1189	c.470C>T	c.(469-471)TCC>TTC	p.S157F	C1S_uc001qsk.2_Missense_Mutation_p.S157F|C1S_uc001qsl.2_Missense_Mutation_p.S157F|C1S_uc009zfr.2_5'UTR|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	157	EGF-like; calcium-binding.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TACTTCTGCTCCTGCCCCCCG	0.453													61	116					0	0	0	0	T	7171649	T	T	7171649	3	4	276	1	0	0	0	0	1	0	0	0	1983	855	30	2	484	2	C1S	12	7171649	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	197731	7171649	126680246	1195	51084											
CD163L1	283316	broad.mit.edu	37	chr12	7527338	7527338	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgtccccatccactaggcGgagccgtttgtcctcttaga	6	11	10	14	2	1	1	0	0	1	1	4	2	4	2	5	2	1	2	5	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:7527338G>A	uc001qsy.2	-	13	3135	c.3109C>T	c.(3109-3111)CGC>TGC	p.R1037C	CD163L1_uc010sge.1_Missense_Mutation_p.R1047C	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1037	SRCR 10.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TCCACTAGGCGGAGCCGTTTG	0.517											OREG0021653	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	41					0	0	0	0	A	7527338	A	A	7527338	3	1	276	1	0	0	0	0	1	0	0	0	2983	1116	39	1	1280	1	CD163L1	12	7527338	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	355689	7527338	126324557	1196	51085											
CD163	9332	broad.mit.edu	37	chr12	7647932	7647932	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctaacagtctctgaatctCcacctcaactgtcccagcac	10	9	4	18	0	3	1	1	1	2	0	6	1	4	1	4	0	3	1	4	0	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:7647932C>T	uc001qsz.3	-	6	1293	c.1165G>A	c.(1165-1167)GAG>AAG	p.E389K	CD163_uc001qta.3_Missense_Mutation_p.E389K|CD163_uc009zfw.2_Missense_Mutation_p.E389K	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	389	SRCR 4.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CTCTGAATCTCCACCTCAACT	0.493													19	101					0	0	0	0	T	7647932	T	T	7647932	3	4	276	1	0	0	0	0	1	0	0	0	2982	864	30	2	2349	2	CD163	12	7647932	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	120594	7647932	126203963	1197	51086											
C3AR1	719	broad.mit.edu	37	chr12	8212050	8212050	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgttaacctagcagaaccCctagggagtgaatctgcaga	12	9	10	10	0	1	3	0	1	1	2	1	4	1	4	3	1	4	3	3	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:8212050C>T	uc001qtv.1	-	2	824	c.732G>A	c.(730-732)AGG>AGA	p.R244R		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	244	Extracellular (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		TAGCAGAACCCCTAGGGAGTG	0.418													18	76					0	0	0	0	T	8212050	T	T	8212050	2	4	276	1	0	0	0	0	0	0	0	1	2215	622	22	4		4	C3AR1	12	8212050	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	564118	8212050	125639845	1198	51087											
NECAP1	25977	broad.mit.edu	37	chr12	8244401	8244402	+	Missense_Mutation	DNP	GG	AA	AA																															tggcattggcttcacagatcGgggagatgccttcgacttta																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:8244401_8244402GG>AA	uc001qtx.2	+	4	416_417	c.338_339GG>AA	c.(337-339)CGG>CAA	p.R113Q	NECAP1_uc001qty.2_Intron	NM_015509	NP_056324	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	113					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				ovary(1)	1				Kidney(36;0.0915)		TTCACAGATCGGGGAGATGCCT	0.431													6	28					0	0	0	0	AA	8244402	AA	AA	8244401	3	1	276	1	0	0	0	0	1	0	0	0	10361	1116	39	1	352	1	NECAP1	12	8244401	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	32351	8244401	125607494	1199	51088											
FAM90A1	55138	broad.mit.edu	37	chr12	8376723	8376723	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttccttttccccaaagttcGgtggaaccagggctgccttc	6	12	9	14	1	0	0	0	0	0	0	4	1	2	1	5	3	2	2	5	3	2	5	rs117679735	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:8376723G>C	uc001qui.2	-	5	771	c.212C>G	c.(211-213)CCG>CGG	p.P71R	FAM90A1_uc001quh.2_Missense_Mutation_p.P71R	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	71							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		CCCAAAGTTCGGTGGAACCAG	0.547													26	184					0	0	0	0	C	8376723	C	C	8376723	3	2	276	1	0	0	0	0	1	0	0	0	5682	1116	39	3	1194	3	FAM90A1	12	8376723	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	132322	8376723	125475172	1200	51089											
STYK1	55359	broad.mit.edu	37	chr12	10772810	10772810	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacagctgcatacagttcaGgtaccaccaactctggtact	11	9	7	14	0	2	0	1	0	1	0	2	0	2	0	3	2	6	5	3	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:10772810G>A	uc001qys.2	-	11	1723	c.1202C>T	c.(1201-1203)CCT>CTT	p.P401L		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	401						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						ATACAGTTCAGGTACCACCAA	0.517										HNSCC(73;0.22)			46	232					0	0	0	0	A	10772810	A	A	10772810	3	1	276	1	0	0	0	0	1	0	0	0	15425	1000	35	4	70	4	STYK1	12	10772810	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2396087	10772810	123079085	1201	51090											
STYK1	55359	broad.mit.edu	37	chr12	10774549	10774549	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctaggatgctggtaggaggGacttcaggatacggtggtgc	8	10	17	6	1	2	0	1	0	1	0	2	4	2	4	0	7	3	2	0	7	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:10774549G>A	uc001qys.2	-	10	1511	c.990C>T	c.(988-990)GTC>GTT	p.V330V		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	330	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						TGGTAGGAGGGACTTCAGGAT	0.423										HNSCC(73;0.22)			14	109					0	0	0	0	A	10774549	A	A	10774549	2	1	276	1	0	0	0	0	0	0	0	1	15425	1161	41	2		2	STYK1	12	10774549	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1739	10774549	123077346	1202	51091											
PRH1	5554	broad.mit.edu	37	chr12	11034878	11034878	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtccttgtgggcggccccCttggggaggtggtccctggg	2	9	19	11	1	0	0	0	0	0	0	2	1	2	1	4	8	0	0	4	8	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:11034878C>T	uc001qzc.2	-	8	1045	c.457G>A	c.(457-459)GGG>AGG	p.G153R	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_RNA|PRB4_uc001qzf.1_Intron	NM_006250	NP_006241	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1	153						extracellular space	protein binding				0				BRCA - Breast invasive adenocarcinoma(232;0.245)		GGGCGGCCCCCTTGGGGAGGT	0.582													10	176					0	0	0	0	T	11034878	T	T	11034878	3	4	276	1	0	0	0	0	1	0	0	0	12544	681	24	4	47	4	PRH1	12	11034878	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	260329	11034878	122817017	1203	51092											
TAS2R13	50838	broad.mit.edu	37	chr12	11061286	11061286	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttctggagatgtttctgcagGgagaaaattaacaggagaaa	15	10	12	4	0	2	3	0	0	2	3	2	6	2	3	0	3	2	2	0	3	4	3	rs140528790		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:11061286G>A	uc001qzg.1	-	1	876	c.612C>T	c.(610-612)TCC>TCT	p.S204S	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron	NM_023920	NP_076409	Q9NYV9	T2R13_HUMAN	taste receptor, type 2, member 13	204	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity	p.S204S(1)		breast(1)|skin(1)	2						GTTTCTGCAGGGAGAAAATTA	0.398													31	69					0	0	0	0	A	11061286	A	A	11061286	2	1	276	1	0	0	0	0	0	0	0	1	15633	1219	43	4		4	TAS2R13	12	11061286	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	26408	11061286	122790609	1204	51093											
PRB3	5544	broad.mit.edu	37	chr12	11420677	11420678	+	Missense_Mutation	DNP	CC	TT	TT																															gaccttgggactggtttcctCcttgtgggggtggtccttct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:11420677_11420678CC>TT	uc001qzs.2	-	3	543_544	c.505_506GG>AA	c.(505-507)GGA>AAA	p.G169K	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	169	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.|6.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			CTGGTTTCCTCCTTGTGGGGGT	0.649													41	266					0	0	0	0	TT	11420678	TT	TT	11420677	3	4	276	1	0	0	0	0	1	0	0	0	12506	855	30	2	431	2	PRB3	12	11420677	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	359391	11420677	122431218	1205	51094											
PRB4	5545	broad.mit.edu	37	chr12	11461790	11461790	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgttggggctggtttcctcCttgtgggcgtcgtccttctg	1	15	14	11	3	1	0	0	0	1	0	5	0	4	0	3	4	0	3	3	4	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:11461790C>T	uc001qzf.1	-	3	161	c.127G>A	c.(127-129)GGA>AGA	p.G43R	PRB4_uc001qzt.2_Missense_Mutation_p.G43R	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	43	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|1.					extracellular region				ovary(1)	1						TGGTTTCCTCCTTGTGGGCGT	0.567										HNSCC(22;0.051)			56	392					0	0	0	0	T	11461790	T	T	11461790	3	4	276	1	0	0	0	0	1	0	0	0	12507	690	24	4	620	4	PRB4	12	11461790	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	41113	11461790	122390105	1206	51095											
PRB2	653247	broad.mit.edu	37	chr12	11546792	11546792	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccttgtggctttcctggagGaggtgggggaccttgaggct	4	12	17	8	0	0	1	0	1	0	0	2	4	2	4	3	7	0	2	3	7	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:11546792G>A	uc010shk.1	-	3	255	c.220C>T	c.(220-222)CCT>TCT	p.P74S		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTCCTGGAGGAGGTGGGGGA	0.602													71	362					0	0	0	0	A	11546792	A	A	11546792	3	1	276	1	0	0	0	0	1	0	0	0	12505	1174	41	2	1034	2	PRB2	12	11546792	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	85002	11546792	122305103	1207	51096											
KIAA1467	57613	broad.mit.edu	37	chr12	13224269	13224269	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccacctcagcagttacttCagaccagaagtctgtcttcc	10	10	7	14	0	4	2	2	0	2	2	5	2	5	2	4	0	3	2	4	0	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:13224269C>T	uc001rbi.2	+	10	1486	c.1463C>T	c.(1462-1464)TCA>TTA	p.S488L	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	488						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		GCAGTTACTTCAGACCAGAAG	0.517													62	54					0	0	0	0	T	13224269	T	T	13224269	3	4	276	1	0	0	0	0	1	0	0	0	8274	838	29	2	1501	2	KIAA1467	12	13224269	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1677477	13224269	120627626	1208	51097											
GRIN2B	2904	broad.mit.edu	37	chr12	13716871	13716871	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagctcgatctcgtcaaactCcctgcgggacttggccgagg	7	8	12	14	4	2	0	1	0	1	0	5	3	3	1	2	3	3	1	2	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:13716871C>T	uc001rbt.2	-	13	3480	c.3301G>A	c.(3301-3303)GAG>AAG	p.E1101K		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1101	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCGTCAAACTCCCTGCGGGAC	0.612													35	33					0	0	0	0	T	13716871	T	T	13716871	3	4	276	1	0	0	0	0	1	0	0	0	6819	864	30	2	1157	2	GRIN2B	12	13716871	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	492602	13716871	120135024	1209	51098											
GRIN2B	2904	broad.mit.edu	37	chr12	13768162	13768162	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatcgttcctcattgatggTgagtgagcccactgccatgt	7	12	11	11	2	1	3	1	3	0	0	3	4	2	3	3	1	2	1	3	1	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:13768162T>G	uc001rbt.2	-	7	1719	c.1540A>C	c.(1540-1542)ACC>CCC	p.T514P		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	514	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCATTGATGGTGAGTGAGCCC	0.532													10	66					0	0	0	0	G	13768162	G	G	13768162	3	3	276	1	0	0	0	0	1	0	0	0	6819	1696	59	5	2942	5	GRIN2B	12	13768162	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	51291	13768162	120083733	1210	51099											
EPS8	2059	broad.mit.edu	37	chr12	15834210	15834210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catgttctctgtccgtctggGaaaaggtaggtgatgatccg	8	12	13	8	2	2	2	0	2	2	0	5	3	4	3	2	3	0	2	2	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:15834210G>A	uc009zif.2	-	3	180	c.86C>T	c.(85-87)TCC>TTC	p.S29F	EPS8_uc001rdb.2_Missense_Mutation_p.S29F|EPS8_uc009zig.2_5'UTR	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	29					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		GTCCGTCTGGGAAAAGGTAGG	0.313													25	123					0	0	0	0	A	15834210	A	A	15834210	3	1	276	1	0	0	0	0	1	0	0	0	5218	1174	41	2	2458	2	EPS8	12	15834210	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2066048	15834210	118017685	1211	51100											
PLCZ1	89869	broad.mit.edu	37	chr12	18876368	18876368	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaaagaattttccggttttCagaatatgtgttgaaaatct	14	16	7	4	1	2	3	1	1	1	2	3	3	3	3	1	1	0	2	1	1	7	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:18876368C>T	uc010sid.1	-	4	435	c.244G>A	c.(244-246)GAA>AAA	p.E82K	PLCZ1_uc001rdv.3_5'UTR|PLCZ1_uc001rdw.3_Intron	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	82					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					TTCCGGTTTTCAGAATATGTG	0.343													12	67					0	0	0	0	T	18876368	T	T	18876368	3	4	276	1	0	0	0	0	1	0	0	0	12099	835	29	2	1630	2	PLCZ1	12	18876368	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3042158	18876368	114975527	1212	51101											
PLEKHA5	54477	broad.mit.edu	37	chr12	19427805	19427805	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtggaaatcgccccaatacaGggcccttatacacagaggcc	12	6	10	13	1	0	1	0	0	0	1	1	2	0	2	4	3	2	0	4	3	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:19427805G>A	uc001reb.2	+	10	1269	c.1183G>A	c.(1183-1185)GGG>AGG	p.G395R	PLEKHA5_uc010sie.1_Missense_Mutation_p.G401R|PLEKHA5_uc001rea.2_Missense_Mutation_p.G395R|PLEKHA5_uc009zin.2_Missense_Mutation_p.G153R|PLEKHA5_uc010sif.1_Missense_Mutation_p.G287R|PLEKHA5_uc010sig.1_Missense_Mutation_p.G287R|PLEKHA5_uc010sih.1_Missense_Mutation_p.G287R|PLEKHA5_uc001rec.1_Missense_Mutation_p.G83R	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	395							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					CCCCAATACAGGGCCCTTATA	0.458													17	71					0	0	0	0	A	19427805	A	A	19427805	3	1	276	1	0	0	0	0	1	0	0	0	12114	1000	35	4	1221	4	PLEKHA5	12	19427805	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	551437	19427805	114424090	1213	51102											
PDE3A	5139	broad.mit.edu	37	chr12	20766428	20766428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcatgggcgaggcccacGgcctcattaccgacctcctg	6	7	11	17	4	2	0	2	0	0	0	3	2	3	0	6	3	1	0	6	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:20766428G>A	uc001reh.1	+	3	1085	c.1063G>A	c.(1063-1065)GGC>AGC	p.G355S		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	355				HGLITDLLADPSLPPNVC -> TASLPTSWQTLLFHQTCA (in Ref. 3 and 4).	lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CGAGGCCCACGGCCTCATTAC	0.537													10	91					0	0	0	0	A	20766428	A	A	20766428	3	1	276	1	0	0	0	0	1	0	0	0	11691	1116	39	1	1073	1	PDE3A	12	20766428	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1338623	20766428	113085467	1214	51103											
SLCO1B3	28234	broad.mit.edu	37	chr12	21015719	21015719	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgcaataggaatgattggtCcagtcattggctttgcactg	10	13	11	7	0	1	1	1	1	0	0	2	2	2	2	1	3	2	3	1	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:21015719C>T	uc001rek.2	+	7	784	c.658C>T	c.(658-660)CCA>TCA	p.P220S	SLCO1B3_uc001rel.2_Missense_Mutation_p.P220S|SLCO1B3_uc010sil.1_Missense_Mutation_p.P220S|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.P45S	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	220	Helical; Name=5; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					AATGATTGGTCCAGTCATTGG	0.333													9	86					0	0	0	0	T	21015719	T	T	21015719	3	4	276	1	0	0	0	0	1	0	0	0	14788	855	30	2	680	2	SLCO1B3	12	21015719	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	249291	21015719	112836176	1215	51104											
SLCO1B1	10599	broad.mit.edu	37	chr12	21325692	21325692	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatttgagatatcctcttctCttgttggttttattgacgga	7	19	9	6	1	2	2	0	2	2	1	4	5	3	3	1	2	0	2	1	2	2	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:21325692C>T	uc001req.3	+	3	297	c.193C>T	c.(193-195)CTT>TTT	p.L65F		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	65	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	ATCCTCTTCTCTTGTTGGTTT	0.313													26	38					0	0	0	0	T	21325692	T	T	21325692	3	4	276	1	0	0	0	0	1	0	0	0	14787	913	32	2	199	2	SLCO1B1	12	21325692	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	309973	21325692	112526203	1216	51105											
SLCO1A2	6579	broad.mit.edu	37	chr12	21453381	21453381	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtctctagtccttcctttgGaagtgtgttgggcaaaaaga	10	13	11	7	0	1	1	0	0	1	1	4	2	3	2	2	2	0	2	2	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:21453381G>A	uc001rer.2	-	7	1062	c.811C>T	c.(811-813)CCA>TCA	p.P271S	SLCO1A2_uc001res.2_Missense_Mutation_p.P271S|SLCO1A2_uc010siq.1_Missense_Mutation_p.P139S|SLCO1A2_uc010sio.1_Missense_Mutation_p.P139S|SLCO1A2_uc010sip.1_Missense_Mutation_p.P139S|SLCO1A2_uc001ret.2_Missense_Mutation_p.P269S|SLCO1A2_uc001reu.2_Missense_Mutation_p.P251S	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	271	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						CCTTCCTTTGGAAGTGTGTTG	0.403													10	61					0	0	0	0	A	21453381	A	A	21453381	3	1	276	1	0	0	0	0	1	0	0	0	14786	1174	41	2	1233	2	SLCO1A2	12	21453381	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	127689	21453381	112398514	1217	51106											
ABCC9	10060	broad.mit.edu	37	chr12	21968824	21968824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatgttctggaacttgagaaGgatctggaggatgggatggg	11	10	17	3	0	2	1	0	1	2	1	2	7	2	6	0	6	1	1	0	6	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:21968824G>A	uc001rfi.1	-	32	3916	c.3896C>T	c.(3895-3897)CCT>CTT	p.P1299L	ABCC9_uc001rfh.2_Missense_Mutation_p.P1299L|ABCC9_uc001rfj.1_Missense_Mutation_p.P1263L	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1299	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AACTTGAGAAGGATCTGGAGG	0.333													12	52					0	0	0	0	A	21968824	A	A	21968824	3	1	276	1	0	0	0	0	1	0	0	0	59	1000	35	4	923	4	ABCC9	12	21968824	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	515443	21968824	111883071	1218	51107											
ABCC9	10060	broad.mit.edu	37	chr12	22005385	22005385	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgcaggaatttcaaaatccCctcctgcattaaatgatcac	13	12	5	11	0	2	1	2	1	0	0	4	2	4	2	3	1	2	2	3	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:22005385C>T	uc001rfi.1	-	21	2580	c.2560G>A	c.(2560-2562)GGG>AGG	p.G854R	ABCC9_uc001rfh.2_Missense_Mutation_p.G854R|ABCC9_uc001rfj.1_Missense_Mutation_p.G818R	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	854	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTCAAAATCCCCTCCTGCATT	0.413													41	40					0	0	0	0	T	22005385	T	T	22005385	3	4	276	1	0	0	0	0	1	0	0	0	59	623	22	4	2303	4	ABCC9	12	22005385	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	36561	22005385	111846510	1219	51108											
ITPR2	3709	broad.mit.edu	37	chr12	26784938	26784938	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agatggagcctctactgagtAccatctgggtcatcatctct	9	12	9	11	0	5	2	2	1	3	1	6	3	5	3	2	2	3	1	2	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:26784938A>C	uc001rhg.2	-	22	3212	c.2795T>G	c.(2794-2796)GTA>GGA	p.V932G		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	932	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCTACTGAGTACCATCTGGGT	0.552													17	119					0	0	0	0	C	26784938	C	C	26784938	3	2	276	1	0	0	0	0	1	0	0	0	7960	391	14	5	5454	5	ITPR2	12	26784938	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	4779553	26784938	107066957	1220	51109											
KIF21A	55605	broad.mit.edu	37	chr12	39696913	39696913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgggactcacagtcccaaGagctccttctgtaacatcaa	11	9	9	12	0	3	1	2	0	1	1	5	2	5	2	2	2	2	2	2	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:39696913G>A	uc001rly.2	-	36	4731	c.4585C>T	c.(4585-4587)CTT>TTT	p.L1529F	KIF21A_uc001rlv.2_Missense_Mutation_p.L474F|KIF21A_uc001rlw.2_Missense_Mutation_p.L799F|KIF21A_uc001rlx.2_Missense_Mutation_p.L1516F|KIF21A_uc001rlz.2_Missense_Mutation_p.L1476F|KIF21A_uc010skl.1_Missense_Mutation_p.L1492F|KIF21A_uc001rlt.2_Missense_Mutation_p.L149F|KIF21A_uc001rlu.2_Missense_Mutation_p.L149F	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1529	WD 4.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				ACAGTCCCAAGAGCTCCTTCT	0.388													21	48					0	0	0	0	A	39696913	A	A	39696913	3	1	276	1	0	0	0	0	1	0	0	0	8327	942	33	2	451	2	KIF21A	12	39696913	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	12911975	39696913	94154982	1221	51110											
KIF21A	55605	broad.mit.edu	37	chr12	39726014	39726014	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgcttttttaaaaattacaaAcctttgcttcttccatctgc	10	17	3	11	1	2	0	0	0	2	0	3	0	3	0	2	0	4	2	2	0	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:39726014A>G	uc001rly.2	-	21	3197	c.3051_splice	c.e21+1	p.K1017_splice	KIF21A_uc001rlv.2_Intron|KIF21A_uc001rlw.2_Splice_Site_p.K334_splice|KIF21A_uc001rlx.2_Splice_Site_p.K1004_splice|KIF21A_uc001rlz.2_Splice_Site_p.K981_splice|KIF21A_uc010skl.1_Splice_Site_p.K1004_splice	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				AAAATTACAAACCTTTGCTTC	0.308													41	77					0	0	0	0	G	39726014	G	G	39726014	5	3	276	1	0	0	0	0	0	0	1	0	8327	57	2	5	2043	5	KIF21A	12	39726014	Splice_Site	SNP	A	TCGA-D6-6516-01A-11D-1870-08	29101	39726014	94125881	1222	51111											
ABCD2	225	broad.mit.edu	37	chr12	39973417	39973417	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccagtccataacagcatcCcatccttaagaaaataaaaa	18	9	3	11	0	0	1	0	0	0	1	4	1	4	1	4	0	2	1	4	0	7	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:39973417C>T	uc001rmb.2	-	8	2223	c.1797G>A	c.(1795-1797)TGG>TGA	p.W599*		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	599	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						TAACAGCATCCCATCCTTAAG	0.318													25	95					0	0	0	0	T	39973417	T	T	39973417	4	4	276	1	0	0	0	0	0	1	0	0	61	624	22	4	437	4	ABCD2	12	39973417	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	247403	39973417	93878478	1223	51112											
LRRK2	120892	broad.mit.edu	37	chr12	40714868	40714868	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caggcctgtgatagagcttcCccattgtgagaactctgaaa	11	10	10	10	0	1	4	0	3	1	2	2	5	2	4	3	1	2	1	3	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:40714868C>T	uc001rmg.3	+	35	5169	c.5048C>T	c.(5047-5049)CCC>CTC	p.P1683L	LRRK2_uc009zjw.2_Missense_Mutation_p.P521L|LRRK2_uc001rmi.2_Missense_Mutation_p.P516L	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1683					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ATAGAGCTTCCCCATTGTGAG	0.383													25	128					0	0	0	0	T	40714868	T	T	40714868	3	4	276	1	0	0	0	0	1	0	0	0	9083	623	22	4	5186	4	LRRK2	12	40714868	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	741451	40714868	93137027	1224	51113											
LRRK2	120892	broad.mit.edu	37	chr12	40758754	40758754	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctttggataggaactggagGaggccatattttactcctgg	9	13	12	7	0	1	0	0	0	1	0	2	4	2	4	2	6	2	0	2	6	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:40758754G>A	uc001rmg.3	+	49	7413	c.7292G>A	c.(7291-7293)GGA>GAA	p.G2431E	LRRK2_uc009zjw.2_Missense_Mutation_p.G1269E|LRRK2_uc001rmi.2_Missense_Mutation_p.G1264E	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2431					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GGAACTGGAGGAGGCCATATT	0.408											OREG0003828	type=REGULATORY REGION|Gene=LRRK2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	11	74					0	0	0	0	A	40758754	A	A	40758754	3	1	276	1	0	0	0	0	1	0	0	0	9083	1174	41	2	7486	2	LRRK2	12	40758754	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	43886	40758754	93093141	1225	51114											
PDZRN4	29951	broad.mit.edu	37	chr12	41967305	41967305	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acaaagagacccgtgcgagaCcgaatcctgaaggaacgtgc	14	4	12	11	4	0	3	0	1	0	2	1	7	1	4	3	1	3	0	3	1	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:41967305C>T	uc010skn.1	+	10	2195	c.2127C>T	c.(2125-2127)GAC>GAT	p.D709D	PDZRN4_uc001rmq.3_Silent_p.D650D|PDZRN4_uc009zjz.2_Silent_p.D648D|PDZRN4_uc001rmr.2_Silent_p.D535D	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	908							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CCGTGCGAGACCGAATCCTGA	0.517													11	73					0	0	0	0	T	41967305	T	T	41967305	2	4	276	1	0	0	0	0	0	0	0	1	11764	506	18	4		4	PDZRN4	12	41967305	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1208551	41967305	91884590	1226	51115											
PUS7L	83448	broad.mit.edu	37	chr12	44148206	44148206	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccacgtttgtgtgctttttcCcgaaatcttactgttaccac	7	16	6	12	2	1	0	0	0	1	0	2	1	2	0	3	0	3	3	3	0	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:44148206C>T	uc001rnq.3	-	2	1332	c.843G>A	c.(841-843)CGG>CGA	p.R281R	PUS7L_uc001rnr.3_Silent_p.R281R|PUS7L_uc001rns.3_Silent_p.R281R|PUS7L_uc009zkb.2_Intron	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	281					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		GTGCTTTTTCCCGAAATCTTA	0.353													71	142					0	0	0	0	T	44148206	T	T	44148206	2	4	276	1	0	0	0	0	0	0	0	1	12899	610	22	4		4	PUS7L	12	44148206	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2180901	44148206	89703689	1227	51116											
SLC38A2	54407	broad.mit.edu	37	chr12	46761092	46761092	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggagatgaacagaatacaGggaaaatattgacacaaatg	21	6	10	4	0	0	4	0	2	0	2	0	6	0	5	0	2	2	0	0	2	8	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:46761092G>A	uc001rpg.2	-	5	786	c.346C>T	c.(346-348)CTG>TTG	p.L116L	SLC38A2_uc010sli.1_5'Flank|SLC38A2_uc001rph.2_Silent_p.L16L	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	116	Helical; (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		ACAGAATACAGGGAAAATATT	0.333													26	182					0	0	0	0	A	46761092	A	A	46761092	2	1	276	1	0	0	0	0	0	0	0	1	14668	991	35	4		4	SLC38A2	12	46761092	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2612886	46761092	87090803	1228	51117											
SLC38A4	55089	broad.mit.edu	37	chr12	47181734	47181734	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgttggccatggcataGgacaagcccaggatcccact	9	8	11	13	0	0	0	0	0	0	0	1	2	1	2	4	4	1	2	4	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:47181734G>A	uc001rpi.2	-	5	690	c.291C>T	c.(289-291)TCC>TCT	p.S97S	SLC38A4_uc001rpj.2_Silent_p.S97S|SLC38A4_uc009zkl.2_Silent_p.S97S	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	97	Helical; (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					CCATGGCATAGGACAAGCCCA	0.428													34	57					0	0	0	0	A	47181734	A	A	47181734	2	1	276	1	0	0	0	0	0	0	0	1	14670	987	35	4		4	SLC38A4	12	47181734	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	420642	47181734	86670161	1229	51118											
COL2A1	1280	broad.mit.edu	37	chr12	48383559	48383559	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttaccggaggccctgcgggGcctggctgaccatcgttgcc	4	8	14	15	3	0	1	0	1	0	0	1	2	0	2	5	5	3	2	5	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:48383559G>A	uc001rqu.2	-	17	1234	c.1053C>T	c.(1051-1053)GGC>GGT	p.G351G	COL2A1_uc009zkw.2_5'Flank|COL2A1_uc001rqv.2_Silent_p.G282G	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	351	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GCCCTGCGGGGCCTGGCTGAC	0.597													29	76					0	0	0	0	A	48383559	A	A	48383559	2	1	276	1	0	0	0	0	0	0	0	1	3702	1190	42	4		4	COL2A1	12	48383559	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1201825	48383559	85468336	1230	51119											
ASB8	140461	broad.mit.edu	37	chr12	48543601	48543601	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgacagaggccccgctctCtaggagagcccgcacacact	10	6	10	15	2	1	3	0	1	1	2	2	4	1	3	3	2	1	2	3	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:48543601C>T	uc001rrh.2	-	4	584	c.415G>A	c.(415-417)GAG>AAG	p.E139K	ASB8_uc010slr.1_Missense_Mutation_p.E135K	NM_024095	NP_077000	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box-containing 8	139	ANK 3.				intracellular signal transduction	cytoplasm|nucleus				kidney(1)	1						GCCCCGCTCTCTAGGAGAGCC	0.527													14	80					0	0	0	0	T	48543601	T	T	48543601	3	4	276	1	0	0	0	0	1	0	0	0	1031	922	32	2	455	2	ASB8	12	48543601	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	160042	48543601	85308294	1231	51120											
CCDC65	85478	broad.mit.edu	37	chr12	49312668	49312668	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgccaccctcaaggccctGagaaagattgttgataaggt	13	9	10	9	0	1	3	1	2	0	2	1	4	1	3	3	2	1	1	3	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:49312668G>A	uc001rso.2	+	6	1235	c.1008G>A	c.(1006-1008)CTG>CTA	p.L336L		NM_033124	NP_149115	Q8IXS2	CCD65_HUMAN	coiled-coil domain containing 65	336										ovary(1)|skin(1)	2						TCAAGGCCCTGAGAAAGATTG	0.488													10	39					0	0	0	0	A	49312668	A	A	49312668	2	1	276	1	0	0	0	0	0	0	0	1	2850	1277	45	2		2	CCDC65	12	49312668	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	769067	49312668	84539227	1232	51121											
TUBA1B	10376	broad.mit.edu	37	chr12	49523492	49523492	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagcctggccaacgtggatgGagatgcactcacgctgcggg	8	6	15	12	3	1	1	1	0	0	1	1	3	1	2	2	4	4	2	2	4	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:49523492G>A	uc001rtm.2	-	2	238	c.17C>T	c.(16-18)TCC>TTC	p.S6F	TUBA1B_uc001rto.2_Intron|TUBA1B_uc001rtk.2_5'UTR|TUBA1B_uc001rtl.2_5'UTR|TUBA1B_uc001rtn.2_5'UTR	NM_006082	NP_006073	P68363	TBA1B_HUMAN	tubulin, alpha, ubiquitous	6					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding				0						AACGTGGATGGAGATGCACTC	0.483													13	62					0	0	0	0	A	49523492	A	A	49523492	3	1	276	1	0	0	0	0	1	0	0	0	16812	1174	41	2	1350	2	TUBA1B	12	49523492	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	210824	49523492	84328403	1233	51122											
TROAP	10024	broad.mit.edu	37	chr12	49719907	49719907	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttccactcgccccagtttcCaggagctaagaagggagaca	11	7	10	13	1	0	2	0	0	0	2	3	4	2	3	4	2	1	2	4	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:49719907C>T	uc001rtx.3	+	6	849	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	TROAP_uc009zlh.2_Nonsense_Mutation_p.Q228*|TROAP_uc001rty.2_5'Flank	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	228					cell adhesion	cytoplasm				ovary(1)	1						CCCCAGTTTCCAGGAGCTAAG	0.527													31	131					0	0	0	0	T	49719907	T	T	49719907	4	4	276	1	0	0	0	0	0	1	0	0	16642	595	21	4	802	4	TROAP	12	49719907	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	196415	49719907	84131988	1234	51123											
DNAJC22	79962	broad.mit.edu	37	chr12	49743028	49743028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttgctggtggctgctgttGgcaaccagacctcagacttt	6	13	11	11	0	2	2	1	0	1	2	2	2	2	2	2	3	3	5	2	3	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:49743028G>A	uc001rua.2	+	2	774	c.373G>A	c.(373-375)GGC>AGC	p.G125S	DNAJC22_uc001rub.2_Missense_Mutation_p.G125S	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	125	Helical; (Potential).				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						GGCTGCTGTTGGCAACCAGAC	0.527													28	168					0	0	0	0	A	49743028	A	A	49743028	3	1	276	1	0	0	0	0	1	0	0	0	4663	1348	47	4	375	4	DNAJC22	12	49743028	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	23121	49743028	84108867	1235	51124											
NCKAP5L	57701	broad.mit.edu	37	chr12	50189930	50189931	+	Missense_Mutation	DNP	GG	AA	AA																															ggggatggaggtggctctggGgaaggccccctaaaggtgct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:50189930_50189931GG>AA	uc009zlk.2	-	8	1914_1915	c.1712_1713CC>TT	c.(1711-1713)TCC>TTT	p.S571F	NCKAP5L_uc001rvc.3_5'Flank|NCKAP5L_uc001rvb.2_Missense_Mutation_p.S164F	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	567	Pro-rich.									central_nervous_system(1)	1						GTGGCTCTGGGGAAGGCCCCCT	0.624													10	34					0	0	0	0	AA	50189931	AA	AA	50189930	3	1	276	1	0	0	0	0	1	0	0	0	10278	1219	43	4	2315	4	NCKAP5L	12	50189930	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	446902	50189930	83661965	1236	51125											
RACGAP1	29127	broad.mit.edu	37	chr12	50400385	50400385	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtcctctgccactttttacgGaaatcctcaaagtccttcgc	8	13	6	14	2	2	0	1	0	1	0	6	1	5	1	4	1	2	0	4	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:50400385G>A	uc001rvt.2	-	5	430	c.120C>T	c.(118-120)TTC>TTT	p.F40F	RACGAP1_uc009zlm.1_Silent_p.F40F|RACGAP1_uc001rvs.2_Silent_p.F40F|RACGAP1_uc001rvu.2_Silent_p.F40F	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	40					blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						ACTTTTTACGGAAATCCTCAA	0.423													23	31					0	0	0	0	A	50400385	A	A	50400385	2	1	276	1	0	0	0	0	0	0	0	1	13042	1165	41	2		2	RACGAP1	12	50400385	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	210455	50400385	83451510	1237	51126											
SMARCD1	6602	broad.mit.edu	37	chr12	50483706	50483706	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaggagaccgatggctttCaggtgaagcggccgggagac	9	5	16	11	3	1	3	1	1	0	2	1	6	1	3	3	5	1	1	3	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:50483706C>T	uc001rvx.3	+	7	981	c.811C>T	c.(811-813)CAG>TAG	p.Q271*	SMARCD1_uc001rvy.3_Nonsense_Mutation_p.Q271*|SMARCD1_uc009zlp.2_Nonsense_Mutation_p.Q230*	NM_003076	NP_003067	Q96GM5	SMRD1_HUMAN	SWI/SNF-related matrix-associated	271	Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin; required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo.|Interaction with SMARCC1 and SMARCC2.				chromatin-mediated maintenance of transcription|nervous system development|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	protein complex scaffold|transcription coactivator activity			ovary(1)	1						CGATGGCTTTCAGGTGAAGCG	0.582													13	58					0	0	0	0	T	50483706	T	T	50483706	4	4	276	1	0	0	0	0	0	1	0	0	14841	827	29	2	837	2	SMARCD1	12	50483706	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	83321	50483706	83368189	1238	51127											
KRT7	3855	broad.mit.edu	37	chr12	52639266	52639267	+	Missense_Mutation	DNP	CC	TT	TT																															ggcgctcaaggatgctcgtgCcaagcaggaggagctggaag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:52639266_52639267CC>TT	uc001saa.1	+	7	1182_1183	c.1055_1056CC>TT	c.(1054-1056)GCC>GTT	p.A352V	KRT7_uc009zmf.1_Intron	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	352	Rod.|Coil 2.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		GATGCTCGTGCCAAGCAGGAGG	0.653													9	59					0	0	0	0	TT	52639267	TT	TT	52639266	3	4	276	1	0	0	0	0	1	0	0	0	8522	739	26	4	1081	4	KRT7	12	52639266	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	2155560	52639266	81212629	1239	51128											
KRT3	3850	broad.mit.edu	37	chr12	53187989	53187989	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgtccaggtagctccgcaGgtagttgatgtgattctcaa	8	13	12	8	1	1	2	1	2	1	0	4	2	3	2	2	2	1	6	2	2	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:53187989G>A	uc001say.2	-	2	838	c.772C>T	c.(772-774)CTG>TTG	p.L258L		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	258	Rod.|Coil 1B.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						TAGCTCCGCAGGTAGTTGATG	0.532													25	174					0	0	0	0	A	53187989	A	A	53187989	2	1	276	1	0	0	0	0	0	0	0	1	8505	991	35	4		4	KRT3	12	53187989	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	548723	53187989	80663906	1240	51129											
ITGB7	3695	broad.mit.edu	37	chr12	53589185	53589185	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatccatgatgagctgtacCacgttgctggagtcctcact	8	11	10	12	1	1	2	1	2	0	0	3	3	3	3	3	1	3	5	3	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:53589185C>T	uc009zmv.2	-	8	1205	c.1134G>A	c.(1132-1134)GTG>GTA	p.V378V	ITGB7_uc001scc.2_Silent_p.V378V|ITGB7_uc010snz.1_RNA	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	378	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						TGAGCTGTACCACGTTGCTGG	0.552													11	74					0	0	0	0	T	53589185	T	T	53589185	2	4	276	1	0	0	0	0	0	0	0	1	7939	581	21	4		4	ITGB7	12	53589185	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	401196	53589185	80262710	1241	51130											
GPR84	53831	broad.mit.edu	37	chr12	54757158	54757158	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcagactacaggtaccaggaTataaataggccagaggggag	15	5	14	7	0	0	2	0	0	0	2	0	4	0	4	2	5	2	2	2	5	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:54757158T>C	uc001sfu.2	-	2	568	c.478A>G	c.(478-480)ATC>GTC	p.I160V		NM_020370	NP_065103	Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	160	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)	2						GGTACCAGGATATAAATAGGC	0.567													3	31					0	0	0	0	C	54757158	C	C	54757158	3	2	276	1	0	0	0	0	1	0	0	0	6752	1406	49	5	716	5	GPR84	12	54757158	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1167973	54757158	79094737	1242	51131											
GTSF1	121355	broad.mit.edu	37	chr12	54857043	54857044	+	Missense_Mutation	DNP	GG	AA	AA																															acctggtggcgagcattgaaGggacaagtagccaatttgct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:54857043_54857044GG>AA	uc001sgb.2	-	4	241_242	c.155_156CC>TT	c.(154-156)CCC>CTT	p.P52L		NM_144594	NP_653195	Q8WW33	GTSF1_HUMAN	gametocyte specific factor 1	52							metal ion binding				0		Myeloproliferative disorder(1001;0.00452)				GAGCATTGAAGGGACAAGTAGC	0.426													13	89					0	0	0	0	AA	54857044	AA	AA	54857043	3	1	276	1	0	0	0	0	1	0	0	0	6925	987	35	4	367	4	GTSF1	12	54857043	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	99885	54857043	78994852	1243	51132											
NCKAP1L	3071	broad.mit.edu	37	chr12	54936457	54936457	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgggaggtgtctcgggccttCcacctaaactgaatgcctgc	7	9	12	13	2	1	1	0	1	1	0	3	2	2	2	4	3	3	0	4	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:54936457C>T	uc001sgc.3	+	31	3451	c.3372C>T	c.(3370-3372)TTC>TTT	p.F1124F	NCKAP1L_uc010sox.1_Silent_p.F666F|NCKAP1L_uc010soy.1_Silent_p.F1074F	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	1124					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						CTCGGGCCTTCCACCTAAACT	0.557													13	81					0	0	0	0	T	54936457	T	T	54936457	2	4	276	1	0	0	0	0	0	0	0	1	10276	854	30	2		2	NCKAP1L	12	54936457	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	79414	54936457	78915438	1244	51133											
PDE1B	5153	broad.mit.edu	37	chr12	54969816	54969816	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcccacattctctgtgctGactgacgtggcagagaagag	10	8	13	10	1	1	4	0	2	1	2	2	6	1	4	1	1	2	2	1	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:54969816G>T	uc001sgd.1	+	13	1474	c.1308G>T	c.(1306-1308)CTG>CTT	p.L436L	PDE1B_uc010soz.1_Silent_p.L299L|PDE1B_uc010spa.1_Silent_p.L395L|PDE1B_uc001sgf.2_Silent_p.L299L|PDE1B_uc001sge.2_Silent_p.L416L|PDE1B_uc009znq.2_Silent_p.L232L	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	436	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TCTCTGTGCTGACTGACGTGG	0.542													28	111					1.55811e-20	1.61742e-20	1	0	T	54969816	T	T	54969816	2	4	276	1	0	0	0	0	0	0	0	1	11688	1277	45	2		2	PDE1B	12	54969816	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	33359	54969816	78882079	1245	51134											
OR6C6	283365	broad.mit.edu	37	chr12	55688295	55688295	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggagacaacaatcatgtggGaagtacaggtggaaaatgct	15	8	13	5	0	1	1	1	0	0	1	1	4	1	3	0	4	3	2	0	4	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:55688295G>A	uc010sph.1	-	1	722	c.722C>T	c.(721-723)TCC>TTC	p.S241F		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						AATCATGTGGGAAGTACAGGT	0.378													13	64					0	0	0	0	A	55688295	A	A	55688295	3	1	276	1	0	0	0	0	1	0	0	0	11248	1174	41	2	224	2	OR6C6	12	55688295	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	718479	55688295	78163600	1246	51135											
OR6C2	341416	broad.mit.edu	37	chr12	55846439	55846439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tattagttctctgctgttggGtggctggcttgatgatcatt	5	18	12	6	0	2	2	1	2	1	0	3	2	2	2	0	3	1	5	0	3	2	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:55846439G>A	uc001sgz.1	+	1	442	c.442G>A	c.(442-444)GTG>ATG	p.V148M		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CTGCTGTTGGGTGGCTGGCTT	0.473													54	92					0	0	0	0	A	55846439	A	A	55846439	3	1	276	1	0	0	0	0	1	0	0	0	11245	1261	44	4	444	4	OR6C2	12	55846439	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	158144	55846439	78005456	1247	51136											
OR10P1	121130	broad.mit.edu	37	chr12	56031407	56031407	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcttctccacctgctcctcCcatctgctcgtggtctctct	2	15	6	18	1	5	0	0	0	5	0	10	0	7	0	4	1	2	2	4	1	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:56031407C>T	uc010spq.1	+	1	732	c.732C>T	c.(730-732)TCC>TCT	p.S244S		NM_206899	NP_996782	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						CCTGCTCCTCCCATCTGCTCG	0.587													21	120					0	0	0	0	T	56031407	T	T	56031407	2	4	276	1	0	0	0	0	0	0	0	1	10969	610	22	4		4	OR10P1	12	56031407	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	184968	56031407	77820488	1248	51137											
METTL7B	196410	broad.mit.edu	37	chr12	56077597	56077598	+	Missense_Mutation	DNP	GG	AA	AA																															aactctctcatccctcccagGgaggtgtgctctttttctgg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:56077597_56077598GG>AA	uc010spr.1	+	2	708_709	c.499_500GG>AA	c.(499-501)GGA>AAA	p.G167K		NM_152637	NP_689850	Q6UX53	MET7B_HUMAN	methyltransferase like 7B precursor	167							methyltransferase activity				0						TCCCTCCCAGGGAGGTGTGCTC	0.525													11	77					0	0	0	0	AA	56077598	AA	AA	56077597	3	1	276	1	0	0	0	0	1	0	0	0	9559	1246	43	4	505	4	METTL7B	12	56077597	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	46190	56077597	77774298	1249	51138											
BLOC1S1	2647	broad.mit.edu	37	chr12	56109967	56109967	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggccaagcagaatgaacgCaaggagctgcagggtgagcc	13	3	15	10	1	0	3	0	2	0	1	0	4	0	4	2	3	5	4	2	3	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:56109967C>T	uc009zny.1	+	1	148	c.132C>T	c.(130-132)CGC>CGT	p.R44R	BLOC1S1_uc001shi.2_Silent_p.R16R|BLOC1S1_uc001shj.3_Silent_p.R44R			P78537	BL1S1_HUMAN	RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 1;          Short=BLOC-1 subunit 1; AltName: Full=GCN5-like protein 1; AltName: Full=Protein RT14;	44	Potential.				cellular membrane organization|melanosome organization|platelet dense granule organization|post-Golgi vesicle-mediated transport	BLOC-1 complex|lysosomal membrane	protein binding				0						AGAATGAACGCAAGGAGCTGC	0.622													4	12					0	0	0	0	T	56109967	T	T	56109967	2	4	276	1	0	0	0	0	0	0	0	1	1451	697	25	4		4	BLOC1S1	12	56109967	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	32370	56109967	77741928	1250	51139											
DNAJC14	85406	broad.mit.edu	37	chr12	56216453	56216453	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtctccttcctcagcaggAtgcagcctattacactcagc	10	10	7	14	0	3	0	2	0	1	0	5	1	4	1	3	1	5	2	3	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:56216453A>G	uc001shx.1	-	5	1902	c.1698T>C	c.(1696-1698)CAT>CAC	p.H566H	DNAJC14_uc001shu.1_Silent_p.H566H|DNAJC14_uc009zob.1_Silent_p.H566H	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	566					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						CCTCAGCAGGATGCAGCCTAT	0.458													26	118					0	0	0	0	G	56216453	G	G	56216453	2	3	276	1	0	0	0	0	0	0	0	1	4655	330	12	5		5	DNAJC14	12	56216453	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	106486	56216453	77635442	1251	51140											
ERBB3	2065	broad.mit.edu	37	chr12	56487254	56487254	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagctctgctaccaccactCtttgaactggaccaaggtgc	9	9	9	14	0	2	1	0	1	2	0	2	2	2	2	3	2	5	3	3	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:56487254C>T	uc001sjh.2	+	12	1593	c.1400C>T	c.(1399-1401)TCT>TTT	p.S467F	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.S408F|ERBB3_uc009zok.2_5'Flank|ERBB3_uc001sjk.2_5'Flank|ERBB3_uc001sjj.1_Missense_Mutation_p.S35F	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	467	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TACCACCACTCTTTGAACTGG	0.522													37	71					0	0	0	0	T	56487254	T	T	56487254	3	4	276	1	0	0	0	0	1	0	0	0	5232	913	32	2	1577	2	ERBB3	12	56487254	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	270801	56487254	77364641	1252	51141											
PA2G4	5036	broad.mit.edu	37	chr12	56504217	56504217	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctgaatttgaggtacatGaagtatatgctgtggatgtt	12	14	12	3	0	0	3	0	3	0	0	0	4	0	4	0	2	3	5	0	2	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:56504217G>T	uc001sjm.2	+	8	1083	c.664G>T	c.(664-666)GAA>TAA	p.E222*	PA2G4_uc009zol.2_Nonsense_Mutation_p.E222*|PA2G4_uc009zom.2_Nonsense_Mutation_p.E222*	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	222					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			TGAGGTACATGAAGTATATGC	0.368													15	75					8.60227e-14	8.86443e-14	1	0	T	56504217	T	T	56504217	4	4	276	1	0	0	0	0	0	1	0	0	11415	1291	45	2	694	2	PA2G4	12	56504217	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	16963	56504217	77347678	1253	51142											
OBFC2B	79035	broad.mit.edu	37	chr12	56622940	56622941	+	Missense_Mutation	DNP	CC	TT	TT																															acacctgcaggcccgcctggCccttccagcaaccctgttag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:56622940_56622941CC>TT	uc001ski.2	+	7	703_704	c.579_580CC>TT	c.(577-582)GGCCCT>GGTTCT	p.P194S	OBFC2B_uc001skk.2_Missense_Mutation_p.P219S|OBFC2B_uc001skj.2_Missense_Mutation_p.P210S	NM_024068	NP_076973	Q9BQ15	SOSB1_HUMAN	oligonucleotide/oligosaccharide-binding fold	194	Pro-rich.				double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	protein binding|single-stranded DNA binding			ovary(1)	1						GCCCGCCTGGCCCTTCCAGCAA	0.599								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					17	86					0	0	0	0	TT	56622941	TT	TT	56622940	3	4	276	1	0	0	0	0	1	0	0	0	10863	726	26	4	601	4	OBFC2B	12	56622940	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	118723	56622940	77228955	1254	51143											
ANKRD52	283373	broad.mit.edu	37	chr12	56638205	56638205	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtaaggtctgccttccctcGatacagcagaaattctacga	12	10	8	11	2	2	1	0	0	2	1	4	3	3	1	2	1	4	2	2	1	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:56638205G>A	uc001skm.3	-	25	2827	c.2737C>T	c.(2737-2739)CGA>TGA	p.R913*		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	913	ANK 26.						protein binding			ovary(2)	2						GCCTTCCCTCGATACAGCAGA	0.517													24	32					0	0	0	0	A	56638205	A	A	56638205	4	1	276	1	0	0	0	0	0	1	0	0	678	1066	37	1	509	1	ANKRD52	12	56638205	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	15265	56638205	77213690	1255	51144											
BAZ2A	11176	broad.mit.edu	37	chr12	57003658	57003658	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttctcagtgtttcgaggtcGaccccgtttgccagtaattg	6	14	10	11	3	1	0	1	0	1	0	4	2	1	0	3	1	1	3	3	1	1	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:57003658G>A	uc001slq.1	-	10	2154	c.1960C>T	c.(1960-1962)CGA>TGA	p.R654*	BAZ2A_uc001slp.1_Nonsense_Mutation_p.R652*|BAZ2A_uc009zow.1_Nonsense_Mutation_p.R622*	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	654	A.T hook 1.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						TTTCGAGGTCGACCCCGTTTG	0.527													8	28					0	0	0	0	A	57003658	A	A	57003658	4	1	276	1	0	0	0	0	0	1	0	0	1333	1066	37	1	3837	1	BAZ2A	12	57003658	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	365453	57003658	76848237	1256	51145											
SDR9C7	121214	broad.mit.edu	37	chr12	57324258	57324258	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acaccagcattgttcaccagGgcccagaggcctgggggtga	9	6	14	12	0	1	2	1	1	0	1	1	2	1	2	4	4	1	2	4	4	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:57324258G>A	uc010sqw.1	-	2	312	c.312C>T	c.(310-312)GCC>GCT	p.A104A		NM_148897	NP_683695	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C,	104						cytoplasm	binding|oxidoreductase activity			central_nervous_system(1)	1						TGTTCACCAGGGCCCAGAGGC	0.562													12	34					0	0	0	0	A	57324258	A	A	57324258	2	1	276	1	0	0	0	0	0	0	0	1	14039	1219	43	4		4	SDR9C7	12	57324258	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	320600	57324258	76527637	1257	51146											
LRP1	4035	broad.mit.edu	37	chr12	57554760	57554760	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgtggatggatggctcacaCcgagacatctttgtcacctc	8	10	11	12	2	3	1	2	0	1	1	4	4	3	3	2	3	0	1	2	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:57554760C>T	uc001snd.2	+	13	2530	c.2064C>T	c.(2062-2064)CAC>CAT	p.H688H		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	688	LDL-receptor class B 6.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ATGGCTCACACCGAGACATCT	0.622													21	135					0	0	0	0	T	57554760	T	T	57554760	2	4	276	1	0	0	0	0	0	0	0	1	9001	506	18	4		4	LRP1	12	57554760	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	230502	57554760	76297135	1258	51147											
LRP1	4035	broad.mit.edu	37	chr12	57569840	57569840	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagcgccctctactggacCgacgtggtggaggacaagat	10	6	14	11	3	1	2	0	0	1	2	1	6	1	5	2	4	2	0	2	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:57569840C>T	uc001snd.2	+	24	4408	c.3942C>T	c.(3940-3942)ACC>ACT	p.T1314T		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1314	LDL-receptor class B 8.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TCTACTGGACCGACGTGGTGG	0.632											OREG0021937	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	91					0	0	0	0	T	57569840	T	T	57569840	2	4	276	1	0	0	0	0	0	0	0	1	9001	639	23	1		1	LRP1	12	57569840	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	15080	57569840	76282055	1259	51148											
MBD6	114785	broad.mit.edu	37	chr12	57919368	57919369	+	Missense_Mutation	DNP	GG	AA	AA																															cagcccccgtttcctcccaaGgggcaatgccccctctccag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:57919368_57919369GG>AA	uc001soj.1	+	6	841_842	c.617_618GG>AA	c.(616-618)AGG>AAA	p.R206K	MBD6_uc001sok.1_Missense_Mutation_p.R73K|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	206	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						TTCCTCCCAAGGGGCAATGCCC	0.644													28	89					0	0	0	0	AA	57919369	AA	AA	57919368	3	1	276	1	0	0	0	0	1	0	0	0	9401	1000	35	4	631	4	MBD6	12	57919368	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	349528	57919368	75932527	1260	51149											
B4GALNT1	2583	broad.mit.edu	37	chr12	58020705	58020705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccaccacgacgtcggagcagGagccaacccgaagggaacca	13	1	12	15	4	0	0	0	0	0	0	1	5	0	3	5	3	4	1	5	3	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:58020705G>A	uc001spg.1	-	11	1856	c.1424C>T	c.(1423-1425)TCC>TTC	p.S475F	B4GALNT1_uc010sru.1_Missense_Mutation_p.S420F	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	475	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GTCGGAGCAGGAGCCAACCCG	0.582													7	27					0	0	0	0	A	58020705	A	A	58020705	3	1	276	1	0	0	0	0	1	0	0	0	1268	1174	41	2	181	2	B4GALNT1	12	58020705	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	101337	58020705	75831190	1261	51150											
CTDSP2	10106	broad.mit.edu	37	chr12	58220853	58220853	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccttgatcttcctctgtcaCctctgggagcaggcaggtcc	5	12	10	14	0	4	1	1	1	3	0	7	2	7	2	4	3	1	2	4	3	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:58220853C>A	uc001sqm.2	-	4	809	c.280G>T	c.(280-282)GTG>TTG	p.V94L	CTDSP2_uc010ssg.1_5'Flank|CTDSP2_uc009zqf.2_5'UTR|CTDSP2_uc009zqg.2_Intron|uc001sqn.2_5'Flank|MIR26A2_hsa-mir-26a-2|MI0000750_5'Flank	NM_005730	NP_005721	O14595	CTDS2_HUMAN	nuclear LIM interactor-interacting factor 2	94					protein dephosphorylation	nucleus|soluble fraction	CTD phosphatase activity|metal ion binding			central_nervous_system(1)	1	all_neural(12;0.00559)|Glioma(12;0.0143)|Melanoma(17;0.122)					TCCTCTGTCACCTCTGGGAGC	0.493													34	70					2.20474e-14	2.27377e-14	1	0	A	58220853	A	A	58220853	3	1	276	1	0	0	0	0	1	0	0	0	4021	507	18	4	555	4	CTDSP2	12	58220853	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	200148	58220853	75631042	1262	51151											
LRIG3	121227	broad.mit.edu	37	chr12	59270358	59270358	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgagatgacaaataactaGgaatatctgctggcaagttg	14	10	10	7	0	1	2	0	2	1	1	1	4	1	3	1	2	2	3	1	2	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:59270358G>A	uc001sqr.2	-	16	2810	c.2564C>T	c.(2563-2565)CCT>CTT	p.P855L	LRIG3_uc009zqh.2_Missense_Mutation_p.P795L|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	855						integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			CAAATAACTAGGAATATCTGC	0.458													9	37					0	0	0	0	A	59270358	A	A	59270358	3	1	276	1	0	0	0	0	1	0	0	0	8996	1000	35	4	811	4	LRIG3	12	59270358	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1049505	59270358	74581537	1263	51152											
USP15	9958	broad.mit.edu	37	chr12	62784990	62784991	+	Missense_Mutation	DNP	CC	TT	TT																															ccagccaggatcaagaacttCcctcagagaatgaaaacagt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:62784990_62784991CC>TT	uc001src.1	+	16	2023_2024	c.2014_2015CC>TT	c.(2014-2016)CCC>TTC	p.P672F	USP15_uc001srb.1_Missense_Mutation_p.P643F	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	672					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TCAAGAACTTCCCTCAGAGAAT	0.371													7	49					0	0	0	0	TT	62784991	TT	TT	62784990	3	4	276	1	0	0	0	0	1	0	0	0	17114	855	30	2	1985	2	USP15	12	62784990	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	3514632	62784990	71066905	1264	51153											
TMEM5	10329	broad.mit.edu	37	chr12	64173779	64173779	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggctctgctcgtttcttatCgccctgtactgcctattctc	3	16	7	15	3	3	0	0	0	3	0	6	0	3	0	2	1	3	4	2	1	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:64173779C>T	uc001srq.1	+	1	143	c.39C>T	c.(37-39)ATC>ATT	p.I13I	TMEM5_uc001srr.1_5'UTR|TMEM5_uc001srs.1_5'Flank	NM_014254	NP_055069	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	13	Helical; Signal-anchor for type II membrane protein; (Potential).					integral to plasma membrane					0		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		CGTTTCTTATCGCCCTGTACT	0.488													22	25					0	0	0	0	T	64173779	T	T	64173779	2	4	276	1	0	0	0	0	0	0	0	1	16240	874	31	1		1	TMEM5	12	64173779	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1388789	64173779	69678116	1265	51154											
LEMD3	23592	broad.mit.edu	37	chr12	65640076	65640076	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcttcgtcttcggactGgcctaaccaattctcaagga	9	12	7	13	2	4	0	2	0	3	0	7	2	4	2	2	3	1	0	2	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:65640076G>T	uc001ssl.1	+	13	2713	c.2707G>T	c.(2707-2709)GGC>TGC	p.G903C	LEMD3_uc009zqo.1_Missense_Mutation_p.G902C	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	903	Interaction with SMAD1, SMAD2, SMAD3 and SMAD5.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		TCTTCGGACTGGCCTAACCAA	0.398													18	100					6.94344e-10	7.10309e-10	1	0	T	65640076	T	T	65640076	3	4	276	1	0	0	0	0	1	0	0	0	8761	1348	47	4	2757	4	LEMD3	12	65640076	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1466297	65640076	68211819	1266	51155											
CPM	1368	broad.mit.edu	37	chr12	69264150	69264150	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caaaagcatcggggaaatttCgattcaagtcatactggtta	14	11	9	7	2	2	0	2	0	0	0	4	2	2	1	0	3	2	2	0	3	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:69264150C>T	uc001sup.2	-	5	522	c.461G>A	c.(460-462)CGA>CAA	p.R154Q	CPM_uc001sur.2_Missense_Mutation_p.R154Q|CPM_uc001suq.2_Missense_Mutation_p.R154Q	NM_198320	NP_938079	P14384	CBPM_HUMAN	carboxypeptidase M precursor	154					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding				0	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			GGGGAAATTTCGATTCAAGTC	0.403													13	91					0	0	0	0	T	69264150	T	T	69264150	3	4	276	1	0	0	0	0	1	0	0	0	3823	884	31	1	890	1	CPM	12	69264150	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3624074	69264150	64587745	1267	51156											
LRRC10	376132	broad.mit.edu	37	chr12	70004462	70004462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caggtagagcttgaccagctCcctgaaggagcacacgtgca	11	6	12	12	1	0	3	0	2	0	1	1	4	1	4	2	2	4	5	2	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:70004462C>T	uc001svc.2	-	1	481	c.157G>A	c.(157-159)GAG>AAG	p.E53K		NM_201550	NP_963844	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	53	LRR 1.					nucleus					0	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TTGACCAGCTCCCTGAAGGAG	0.582													12	40					0	0	0	0	T	70004462	T	T	70004462	3	4	276	1	0	0	0	0	1	0	0	0	9017	864	30	2	680	2	LRRC10	12	70004462	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	740312	70004462	63847433	1268	51157											
PTPRB	5787	broad.mit.edu	37	chr12	70918333	70918333	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgtagctttcttgctctgagGacatctcttacacactgatg	8	14	8	11	1	3	2	0	2	3	0	4	3	3	3	0	1	3	3	0	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:70918333G>A	uc001swb.3	-	31	5919	c.5889C>T	c.(5887-5889)GTC>GTT	p.V1963V	uc001svz.2_Intron|PTPRB_uc010sto.1_Silent_p.V1873V|PTPRB_uc010stp.1_Silent_p.V1873V|PTPRB_uc001swc.3_Silent_p.V2181V|PTPRB_uc001swa.3_Silent_p.V2093V	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1963	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTGCTCTGAGGACATCTCTTA	0.428													6	65					0	0	0	0	A	70918333	A	A	70918333	2	1	276	1	0	0	0	0	0	0	0	1	12861	1161	41	2		2	PTPRB	12	70918333	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	913871	70918333	62933562	1269	51158											
KCNC2	3747	broad.mit.edu	37	chr12	75601548	75601548	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgaagcagccgcctggcccGggggacagcgggggcgctct	5	4	18	14	5	1	0	0	0	1	0	2	2	1	1	3	5	3	2	3	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:75601548G>A	uc001sxg.1	-	2	760	c.216C>T	c.(214-216)CCC>CCT	p.P72P	KCNC2_uc009zry.2_Silent_p.P72P|KCNC2_uc001sxe.2_Silent_p.P72P|KCNC2_uc001sxf.2_Silent_p.P72P|KCNC2_uc010stw.1_Silent_p.P72P	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	72	Gly/Pro-rich (insert).|Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						CGCCTGGCCCGggggacagcg	0.532													2	0					0	0	0	0	A	75601548	A	A	75601548	2	1	276	1	0	0	0	0	0	0	0	1	8054	1103	39	1		1	KCNC2	12	75601548	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4683215	75601548	58250347	1270	51159											
NAV3	89795	broad.mit.edu	37	chr12	78553043	78553043	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgactggccgattgcaaagtCtaactatgacagcggaacaa	14	8	10	9	2	1	2	0	2	1	0	1	4	1	3	1	2	4	1	1	2	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:78553043C>T	uc001syp.2	+	23	5019	c.4846C>T	c.(4846-4848)CTA>TTA	p.L1616L	NAV3_uc001syo.2_Silent_p.L1616L|NAV3_uc010sub.1_Silent_p.L1102L|NAV3_uc009zsf.2_Silent_p.L447L	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1616	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ATTGCAAAGTCTAACTATGAC	0.393										HNSCC(70;0.22)			6	51					0	0	0	0	T	78553043	T	T	78553043	2	4	276	1	0	0	0	0	0	0	0	1	10238	912	32	2		2	NAV3	12	78553043	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2951495	78553043	55298852	1271	51160											
PPFIA2	8499	broad.mit.edu	37	chr12	81747119	81747119	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatccccaagagatttcacCtgaatggtgaatgaaaaaat	16	10	8	7	0	1	5	1	4	0	1	2	6	2	5	3	1	0	0	3	1	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:81747119C>T	uc001szo.1	-	17	1935	c.1774_splice	c.e17-1	p.V592_splice	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_Splice_Site|PPFIA2_uc010suh.1_Splice_Site|PPFIA2_uc010sui.1_Splice_Site|PPFIA2_uc010suj.1_Splice_Site|PPFIA2_uc009zsi.1_Splice_Site|PPFIA2_uc010suf.1_Splice_Site|PPFIA2_uc009zsh.2_Splice_Site	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2											ovary(3)|lung(2)|pancreas(1)	6						GAGATTTCACCTGAATGGTGA	0.373													15	40					0	0	0	0	T	81747119	T	T	81747119	5	4	276	1	0	0	0	0	0	0	1	0	12365	695	24	4	2064	4	PPFIA2	12	81747119	Splice_Site	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3194076	81747119	52104776	1272	51161											
TSPAN19	144448	broad.mit.edu	37	chr12	85413439	85413439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cattcagaatagtccacttgGttatatcttcaggcttatct	10	16	6	9	0	4	1	2	0	2	1	5	1	5	1	1	2	0	2	1	2	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:85413439G>A	uc009zsj.2	-	6	517	c.416C>T	c.(415-417)ACC>ATC	p.T139I		NM_001100917	NP_001094387	P0C672	TSN19_HUMAN	tetraspanin 19	139						integral to membrane				ovary(1)	1						AGTCCACTTGGTTATATCTTC	0.328													35	133					0	0	0	0	A	85413439	A	A	85413439	3	1	276	1	0	0	0	0	1	0	0	0	16710	1261	44	4	346	4	TSPAN19	12	85413439	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3666320	85413439	48438456	1273	51162											
LRRIQ1	84125	broad.mit.edu	37	chr12	85515605	85515605	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctggcactttgtcagtctCagattcgagaattcaacttg	9	14	8	10	1	3	2	3	0	1	2	6	3	4	2	1	1	1	1	1	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:85515605C>T	uc001tac.2	+	16	3619	c.3508C>T	c.(3508-3510)CAG>TAG	p.Q1170*	LRRIQ1_uc001tab.1_Nonsense_Mutation_p.Q1170*	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1170										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TTGTCAGTCTCAGATTCGAGA	0.353													14	52					0	0	0	0	T	85515605	T	T	85515605	4	4	276	1	0	0	0	0	0	1	0	0	9079	827	29	2	3566	2	LRRIQ1	12	85515605	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	102166	85515605	48336290	1274	51163											
LRRIQ1	84125	broad.mit.edu	37	chr12	85518236	85518236	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccataagaatcccatttaagGaagtagtaatgacaaattct	17	11	6	7	0	1	2	0	1	1	1	2	3	2	3	2	1	0	2	2	1	7	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:85518236G>A	uc001tac.2	+	17	4057	c.3946G>A	c.(3946-3948)GAA>AAA	p.E1316K	LRRIQ1_uc001tab.1_Missense_Mutation_p.E1316K	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1316										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CCCATTTAAGGAAGTAGTAAT	0.323													119	250					0	0	0	0	A	85518236	A	A	85518236	3	1	276	1	0	0	0	0	1	0	0	0	9079	1175	41	2	4008	2	LRRIQ1	12	85518236	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2631	85518236	48333659	1275	51164											
CEP290	80184	broad.mit.edu	37	chr12	88454692	88454692	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttcaactgttcattttctCtctggactttttcaactact	7	21	3	10	0	5	0	3	0	2	0	6	1	5	1	0	1	3	1	0	1	3	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:88454692C>T	uc001tar.2	-	47	6781	c.6437G>A	c.(6436-6438)AGA>AAA	p.R2146K	CEP290_uc001taq.2_Missense_Mutation_p.R1206K	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	2146	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						TTCATTTTCTCTCTGGACTTT	0.299													4	14					0	0	0	0	T	88454692	T	T	88454692	3	4	276	1	0	0	0	0	1	0	0	0	3268	913	32	2	1034	2	CEP290	12	88454692	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2936456	88454692	45397203	1276	51165											
TMTC3	160418	broad.mit.edu	37	chr12	88586521	88586522	+	Missense_Mutation	DNP	CC	TT	TT																															acttaaagaaccaaatgaagCcctaaaaaactttaatcgtg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:88586521_88586522CC>TT	uc001tau.2	+	13	2067_2068	c.1847_1848CC>TT	c.(1846-1848)GCC>GTT	p.A616V		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	616	TPR 6.					integral to membrane	binding			skin(1)	1						CCAAATGAAGCCCTAAAAAACT	0.342													28	75					0	0	0	0	TT	88586522	TT	TT	88586521	3	4	276	1	0	0	0	0	1	0	0	0	16328	739	26	4	1893	4	TMTC3	12	88586521	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	131829	88586521	45265374	1277	51166											
KERA	11081	broad.mit.edu	37	chr12	91449634	91449634	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgtaattgttctaaacttCttggcaatggagaaggtacc	12	14	9	6	0	2	1	0	0	2	1	2	2	2	1	1	3	2	4	1	3	6	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:91449634C>T	uc001tbl.2	-	2	1044	c.425G>A	c.(424-426)AGA>AAA	p.R142K		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	142	LRR 3.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						TTCTAAACTTCTTGGCAATGG	0.418													45	103					0	0	0	0	T	91449634	T	T	91449634	3	4	276	1	0	0	0	0	1	0	0	0	8182	913	32	2	641	2	KERA	12	91449634	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2863113	91449634	42402261	1278	51167											
C12orf74	338809	broad.mit.edu	37	chr12	93100531	93100531	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccagtttgaccggcaagccCcaggccgcatctccacctcg	7	7	9	18	3	1	1	0	1	1	0	4	1	2	1	7	2	1	3	7	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:93100531C>T	uc001tch.1	+	2	354	c.124C>T	c.(124-126)CCA>TCA	p.P42S	C12orf74_uc001tci.2_Missense_Mutation_p.P42S	NM_001037671	NP_001032760	Q32Q52	CL074_HUMAN	hypothetical protein LOC338809	42											0						CCGGCAAGCCCCAGGCCGCAT	0.642													7	70					0	0	0	0	T	93100531	T	T	93100531	3	4	276	1	0	0	0	0	1	0	0	0	1720	623	22	4	126	4	C12orf74	12	93100531	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1650897	93100531	40751364	1279	51168											
EEA1	8411	broad.mit.edu	37	chr12	93285445	93285445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgacgtccactgtgtttataGgagttgctgatgaatctaaa	11	14	10	6	1	1	3	0	3	1	0	2	4	2	4	1	1	1	3	1	1	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:93285445G>A	uc001tck.2	-	2	342	c.77C>T	c.(76-78)CCT>CTT	p.P26L		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	26					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TGTGTTTATAGGAGTTGCTGA	0.358													55	130					0	0	0	0	A	93285445	A	A	93285445	3	1	276	1	0	0	0	0	1	0	0	0	4943	1000	35	4	4270	4	EEA1	12	93285445	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	184914	93285445	40566450	1280	51169											
PLXNC1	10154	broad.mit.edu	37	chr12	94613811	94613811	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gactacagtgactatggtggGaagcttctctccaagacact	11	10	10	10	0	1	2	0	1	1	1	3	4	2	3	1	2	2	1	1	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:94613811G>A	uc001tdc.2	+	6	1823	c.1574G>A	c.(1573-1575)GGA>GAA	p.G525E		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	525	Extracellular (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						ACTATGGTGGGAAGCTTCTCT	0.478													43	210					0	0	0	0	A	94613811	A	A	94613811	3	1	276	1	0	0	0	0	1	0	0	0	12181	1174	41	2	1596	2	PLXNC1	12	94613811	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1328366	94613811	39238084	1281	51170											
PLXNC1	10154	broad.mit.edu	37	chr12	94642126	94642126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcaagatcttaccaccatcCtttgcaaaattaaaggcatc	15	11	4	11	0	2	1	1	0	1	1	4	1	3	1	3	1	2	2	3	1	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:94642126C>T	uc001tdc.2	+	14	2965	c.2716C>T	c.(2716-2718)CTT>TTT	p.L906F		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	906	Extracellular (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						TACCACCATCCTTTGCAAAAT	0.393													19	82					0	0	0	0	T	94642126	T	T	94642126	3	4	276	1	0	0	0	0	1	0	0	0	12181	681	24	4	2770	4	PLXNC1	12	94642126	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	28315	94642126	39209769	1282	51171											
ANKS1B	56899	broad.mit.edu	37	chr12	99223030	99223030	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctcctccttgcatcgccCtgcatgataatgtgaggaac	8	12	8	13	1	1	2	0	2	1	0	4	3	2	3	3	1	3	2	3	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:99223030C>T	uc001tge.1	-	19	3405	c.2988G>A	c.(2986-2988)CAG>CAA	p.Q996Q	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc001tgk.2_Silent_p.Q293Q|ANKS1B_uc010svd.1_Silent_p.Q2Q|ANKS1B_uc001tgd.1_Intron|ANKS1B_uc009ztq.2_5'UTR|ANKS1B_uc010sve.1_Silent_p.Q2Q|ANKS1B_uc001tgh.3_Silent_p.Q2Q|ANKS1B_uc001tgi.2_Silent_p.Q222Q|ANKS1B_uc009ztr.2_Intron|ANKS1B_uc001tgj.2_Intron|ANKS1B_uc009ztp.2_Silent_p.Q2Q|ANKS1B_uc010svf.1_Silent_p.Q2Q|ANKS1B_uc001tgg.3_Intron|ANKS1B_uc010svg.1_Intron|ANKS1B_uc009zts.1_Silent_p.Q222Q	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	996						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TTGCATCGCCCTGCATGATAA	0.468													41	221					0	0	0	0	T	99223030	T	T	99223030	2	4	276	1	0	0	0	0	0	0	0	1	689	680	24	4		4	ANKS1B	12	99223030	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4580904	99223030	34628865	1283	51172											
ANKS1B	56899	broad.mit.edu	37	chr12	99478745	99478745	+	Frame_Shift_Del	DEL	C	-	-																															tgtagaattctttgtctgtgCccagaattaaggattccaat																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:99478745delC	uc001tge.1	-	16	3000	c.2583delG	c.(2581-2583)GGGfs	p.G861fs	ANKS1B_uc001tgf.1_Frame_Shift_Del_p.G437fs|ANKS1B_uc001tgk.2_Frame_Shift_Del_p.G158fs|ANKS1B_uc001tgd.1_Frame_Shift_Del_p.G87fs|ANKS1B_uc001tgi.2_Frame_Shift_Del_p.G87fs|ANKS1B_uc009ztr.2_Frame_Shift_Del_p.G87fs|ANKS1B_uc001tgj.2_Frame_Shift_Del_p.G87fs|ANKS1B_uc001tgg.3_Frame_Shift_Del_p.G30fs|ANKS1B_uc010svg.1_Frame_Shift_Del_p.G56fs|ANKS1B_uc009zts.1_Frame_Shift_Del_p.G87fs|ANKS1B_uc001tgm.1_Frame_Shift_Del_p.G87fs	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	861	SAM 1.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TTTGTCTGTGCCCAGAATTAA	0.388													---	---	---								-	99478745	-	-	99478745	7	5	276	1	0	1	0	1	0	0	0	0	689	726	26	0	1398	0	ANKS1B	12	99478745	Frame_Shift_Del	DEL	C	TCGA-D6-6516-01A-11D-1870-08	255715	99478745	34373150	1284	51173											
GOLGA2B	55592	broad.mit.edu	37	chr12	100567228	100567228	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctccgctcactctgggagaGaggcagggccagctttcatt	7	10	12	12	1	4	1	2	0	2	1	5	3	4	2	2	3	1	3	2	3	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:100567228G>A	uc001tgu.2	-						GOLGA2B_uc001tgz.3_RNA	NM_017600	NP_060070			golgi autoantigen, golgin subfamily a, 2-like 1												0						CTCTGGGAGAGAGGCAGGGCC	0.383													3	20					0	0	0	0	A	100567228	A	A	100567228	1	1	276	0	1	0	0	0	0	0	0	0	6590	957	33	2		2	GOLGA2B	12	100567228	5'Flank	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1088483	100567228	33284667	1285	51174											
SPIC	121599	broad.mit.edu	37	chr12	101873414	101873415	+	Missense_Mutation	DNP	CC	TT	TT																															tcctcatgtcaaaggaaattCcagctgctatggagtgttgc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:101873414_101873415CC>TT	uc001tid.2	+	4	311_312	c.152_153CC>TT	c.(151-153)TCC>TTT	p.S51F	SPIC_uc009zua.2_5'UTR|SPIC_uc010svp.1_Missense_Mutation_p.S50F	NM_152323	NP_689536	Q8N5J4	SPIC_HUMAN	Spi-C transcription factor (Spi-1/PU.1 related)	51						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						AAAGGAAATTCCAGCTGCTATG	0.356													9	56					0	0	0	0	TT	101873415	TT	TT	101873414	3	4	276	1	0	0	0	0	1	0	0	0	15117	855	30	2	156	2	SPIC	12	101873414	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1306186	101873414	31978481	1286	51175											
PAH	5053	broad.mit.edu	37	chr12	103246621	103246621	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtatacatgggcttggatcCatgtctgatgtactgtgtgc	7	14	13	7	0	1	1	0	1	1	0	2	2	2	2	1	3	3	3	1	3	3	4	rs62507286		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:103246621C>T	uc001tjq.1	-	8	1286	c.814G>A	c.(814-816)GGA>AGA	p.G272R		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	272					catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	GGCTTGGATCCATGTCTGATG	0.562													51	87					0	0	0	0	T	103246621	T	T	103246621	3	4	276	1	0	0	0	0	1	0	0	0	11448	603	21	4	572	4	PAH	12	103246621	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1373207	103246621	30605274	1287	51176											
TXNRD1	7296	broad.mit.edu	37	chr12	104645324	104645324	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctaaagatcatcaccctggTaaaactttgccagagaaccc	14	8	7	12	0	2	2	2	0	0	2	2	3	2	2	3	1	3	2	3	1	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:104645324T>A	uc010swk.1	+	2	133	c.111T>A	c.(109-111)GGT>GGA	p.G37G	TXNRD1_uc001tkm.1_Silent_p.G40G	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	37					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						ATCACCCTGGTAAAACTTTGC	0.433													10	31					0	0	0	0	A	104645324	A	A	104645324	2	1	276	1	0	0	0	0	0	0	0	1	16875	1625	57	5		5	TXNRD1	12	104645324	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1398703	104645324	29206571	1288	51177											
POLR3B	55703	broad.mit.edu	37	chr12	106826181	106826181	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattgttaaattagccagtaActtgggagtagaagatgtga	14	12	11	4	0	0	3	0	1	0	2	0	4	0	4	1	1	2	3	1	1	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:106826181A>G	uc001tlp.2	+	15	1772	c.1550A>G	c.(1549-1551)AAC>AGC	p.N517S	POLR3B_uc001tlq.2_Missense_Mutation_p.N459S	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	517					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTAGCCAGTAACTTGGGAGTA	0.368													68	105					0	0	0	0	G	106826181	G	G	106826181	3	3	276	1	0	0	0	0	1	0	0	0	12284	43	2	5	1608	5	POLR3B	12	106826181	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	2180857	106826181	27025714	1289	51178											
ASCL4	121549	broad.mit.edu	37	chr12	108169094	108169094	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgcccggactcccgcggagGgaccccctcagggtcgccct	4	5	13	19	4	1	0	1	0	0	0	3	3	2	3	5	4	1	0	5	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:108169094G>A	uc001tmr.2	+	1	933	c.102G>A	c.(100-102)AGG>AGA	p.R34R		NM_203436	NP_982260	Q6XD76	ASCL4_HUMAN	achaete-scute complex-like 4	33					regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)	1						TCCCGCGGAGGGACCCCCTCA	0.731													8	51					0	0	0	0	A	108169094	A	A	108169094	2	1	276	1	0	0	0	0	0	0	0	1	1038	1223	43	4		4	ASCL4	12	108169094	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1342913	108169094	25682801	1290	51179											
WSCD2	9671	broad.mit.edu	37	chr12	108589835	108589835	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatgcatctgggcagaggtTtccgggacacaggtgaagcc	10	7	14	10	1	1	2	0	1	1	1	2	3	2	3	2	4	2	3	2	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:108589835T>A	uc001tms.2	+	2	970	c.226T>A	c.(226-228)TTC>ATC	p.F76I	WSCD2_uc001tmt.2_Missense_Mutation_p.F76I	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	76						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GGGCAGAGGTTTCCGGGACAC	0.622													37	179					0	0	0	0	A	108589835	A	A	108589835	3	1	276	1	0	0	0	0	1	0	0	0	17475	1841	64	5	228	5	WSCD2	12	108589835	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	420741	108589835	25262060	1291	51180											
SSH1	54434	broad.mit.edu	37	chr12	109182304	109182304	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcctggctgggcataaccagGgggcccagctcgtggagcgc	6	5	17	13	2	0	0	0	0	0	0	1	1	0	1	3	5	3	3	3	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:109182304G>A	uc001tnm.2	-	15	2697	c.2610C>T	c.(2608-2610)CCC>CCT	p.P870P	SSH1_uc001tnl.2_Silent_p.P558P	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	870					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						GCATAACCAGGGGGCCCAGCT	0.667													5	37					0	0	0	0	A	109182304	A	A	109182304	2	1	276	1	0	0	0	0	0	0	0	1	15250	1219	43	4		4	SSH1	12	109182304	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	592469	109182304	24669591	1292	51181											
DAO	1610	broad.mit.edu	37	chr12	109290808	109290808	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccccttggatgaagcacttCattctcacccatgacccaga	10	9	7	15	0	2	3	2	2	1	1	3	4	2	4	4	1	1	1	4	1	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:109290808C>T	uc001tnr.3	+	8	792	c.639C>T	c.(637-639)TTC>TTT	p.F213F	DAO_uc001tnq.3_Silent_p.F147F|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_Intron	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	213					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2						TGAAGCACTTCATTCTCACCC	0.547													20	88					0	0	0	0	T	109290808	T	T	109290808	2	4	276	1	0	0	0	0	0	0	0	1	4248	825	29	2		2	DAO	12	109290808	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	108504	109290808	24561087	1293	51182											
USP30	84749	broad.mit.edu	37	chr12	109522852	109522852	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgtcagcgccgatgcccttCcctctcccagttgttcccga	4	11	8	18	3	2	0	1	0	1	0	5	2	4	0	5	0	2	2	5	0	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:109522852C>T	uc010sxi.1	+	12	1367	c.1263C>T	c.(1261-1263)TTC>TTT	p.F421F	USP30_uc001tnu.3_Silent_p.F390F|USP30_uc001tnw.3_Silent_p.F138F	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	421	Cytoplasmic (Potential).				ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1						CGATGCCCTTCCCTCTCCCAG	0.502													71	350					0	0	0	0	T	109522852	T	T	109522852	2	4	276	1	0	0	0	0	0	0	0	1	17129	854	30	2		2	USP30	12	109522852	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	232044	109522852	24329043	1294	51183											
C12orf76	400073	broad.mit.edu	37	chr12	110495088	110495088	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctttcagcaaagttcctctCccccttacagctcctaaggt	8	12	5	16	0	2	0	1	0	1	0	5	0	4	0	5	1	3	3	5	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:110495088C>T	uc001tqd.1	-	4	570	c.205G>A	c.(205-207)GAG>AAG	p.E69K	C12orf76_uc001tqe.1_RNA|C12orf76_uc010sxx.1_RNA|uc001tqf.1_Intron	NM_207435	NP_997318	Q8N812	CL076_HUMAN	hypothetical protein LOC400073	69										large_intestine(1)	1						AAGTTCCTCTCCCCCTTACAG	0.512													4	35					0	0	0	0	T	110495088	T	T	110495088	3	4	276	1	0	0	0	0	1	0	0	0	1721	864	30	2	210	2	C12orf76	12	110495088	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	972236	110495088	23356807	1295	51184											
CUX2	23316	broad.mit.edu	37	chr12	111776107	111776107	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagggcagcggctgtttgggGaaagcatcctgggtctgaca	8	8	16	9	1	1	1	0	1	1	0	2	2	2	2	1	5	2	4	1	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:111776107G>A	uc001tsa.1	+	20	3367	c.3214G>A	c.(3214-3216)GAA>AAA	p.E1072K		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1072	CUT 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCTGTTTGGGGAAAGCATCCT	0.622													9	68					0	0	0	0	A	111776107	A	A	111776107	3	1	276	1	0	0	0	0	1	0	0	0	4082	1175	41	2	3292	2	CUX2	12	111776107	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1281019	111776107	22075788	1296	51185											
CUX2	23316	broad.mit.edu	37	chr12	111785402	111785402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgatccaagcgggggtcctgGaatcctaccgccaggccact	8	7	12	14	2	0	1	0	1	0	0	3	2	3	2	6	4	2	0	6	4	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:111785402G>A	uc001tsa.1	+	22	3887	c.3734G>A	c.(3733-3735)GGA>GAA	p.G1245E		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GGGGGTCCTGGAATCCTACCG	0.652													12	92					0	0	0	0	A	111785402	A	A	111785402	3	1	276	1	0	0	0	0	1	0	0	0	4082	1174	41	2	3820	2	CUX2	12	111785402	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	9295	111785402	22066493	1297	51186											
ATXN2	6311	broad.mit.edu	37	chr12	111951193	111951193	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgatgaccacgttccccccGagggactggtccttgctact	6	10	10	15	2	0	2	0	2	0	0	2	4	2	3	5	2	2	2	5	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:111951193G>A	uc001tsj.2	-	11	2168	c.2006C>T	c.(2005-2007)TCG>TTG	p.S669L	ATXN2_uc001tsh.2_Missense_Mutation_p.S404L|ATXN2_uc001tsi.2_Missense_Mutation_p.S380L|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_Missense_Mutation_p.S404L	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	669	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						CGTTCCCCCCGAGGGACTGGT	0.512													37	49					0	0	0	0	A	111951193	A	A	111951193	3	1	276	1	0	0	0	0	1	0	0	0	1213	1059	37	1	1995	1	ATXN2	12	111951193	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	165791	111951193	21900702	1298	51187											
ACAD10	80724	broad.mit.edu	37	chr12	112182645	112182646	+	Missense_Mutation	DNP	CC	TT	TT																															aggcagcaggagttatagctCcgttccagaagcttccccag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:112182645_112182646CC>TT	uc001tsq.2	+	13	2113_2114	c.1913_1914CC>TT	c.(1912-1914)TCC>TTT	p.S638F	ACAD10_uc001tsp.2_Missense_Mutation_p.S638F|ACAD10_uc009zvx.2_Missense_Mutation_p.S669F|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	638							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						AGTTATAGCTCCGTTCCAGAAG	0.564													15	64					0	0	0	0	TT	112182646	TT	TT	112182645	3	4	276	1	0	0	0	0	1	0	0	0	108	855	30	2	2056	2	ACAD10	12	112182645	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	231452	112182645	21669250	1299	51188											
MED13L	23389	broad.mit.edu	37	chr12	116434339	116434339	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggcagttgttcaattttagGaggaattgcccatgaaggcc	10	11	13	7	0	1	1	1	1	0	0	1	3	1	3	2	4	1	3	2	4	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:116434339G>A	uc001tvw.2	-	16	2993	c.2938C>T	c.(2938-2940)CCT>TCT	p.P980S		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	980					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TCAATTTTAGGAGGAATTGCC	0.458													15	64					0	0	0	0	A	116434339	A	A	116434339	3	1	276	1	0	0	0	0	1	0	0	0	9484	1174	41	2	3758	2	MED13L	12	116434339	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4251694	116434339	17417556	1300	51189											
SRRM4	84530	broad.mit.edu	37	chr12	119588916	119588916	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccatgaaagggtgttccCgcagctcctcctatgccagc	8	8	9	16	1	0	1	0	1	0	0	3	1	3	1	5	1	3	3	5	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:119588916C>T	uc001txa.1	+	10	1463	c.1171C>T	c.(1171-1173)CGC>TGC	p.R391C		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	391	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						AGGGTGTTCCCGCAGCTCCTC	0.592													5	48					0	0	0	0	T	119588916	T	T	119588916	3	4	276	1	0	0	0	0	1	0	0	0	15237	652	23	1	1209	1	SRRM4	12	119588916	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3154577	119588916	14262979	1301	51190											
CCDC60	160777	broad.mit.edu	37	chr12	119866561	119866561	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcaaaaaggaccttatacGaagccggtgagtgagcccag	13	6	11	11	2	1	2	1	2	0	0	1	4	1	3	4	2	3	0	4	2	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:119866561G>A	uc001txe.2	+	2	629	c.164G>A	c.(163-165)CGA>CAA	p.R55Q	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	55										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GACCTTATACGAAGCCGGTGA	0.478													4	12					0	0	0	0	A	119866561	A	A	119866561	3	1	276	1	0	0	0	0	1	0	0	0	2844	1058	37	1	170	1	CCDC60	12	119866561	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	277645	119866561	13985334	1302	51191											
HNF1A	6927	broad.mit.edu	37	chr12	121416883	121416883	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccaccagaaagccgtggtGgagacccttctgcagtaagg	10	6	13	12	1	1	2	0	0	1	2	1	3	1	2	4	3	2	2	4	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:121416883G>A	uc001tzg.2	+	1	335	c.312G>A	c.(310-312)GTG>GTA	p.V104V	HNF1A_uc001tze.1_Silent_p.V104V|HNF1A_uc001tzf.2_Silent_p.V104V|HNF1A_uc010szn.1_Silent_p.V104V	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	104					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AAGCCGTGGTGGAGACCCTTC	0.642									Hepatic_Adenoma_Familial_Clustering_of				5	14					0	0	0	0	A	121416883	A	A	121416883	2	1	276	1	0	0	0	0	0	0	0	1	7290	1335	47	4		4	HNF1A	12	121416883	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1550322	121416883	12435012	1303	51192											
RSRC2	65117	broad.mit.edu	37	chr12	123001925	123001925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggatctcgatttcttccgctCcctactcctggatcgagact	6	13	8	14	3	2	1	0	0	2	1	7	5	5	3	3	2	1	1	3	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:123001925C>T	uc001ucr.2	-	5	597	c.451G>A	c.(451-453)GAG>AAG	p.E151K	RSRC2_uc001uco.2_5'UTR|RSRC2_uc001ucp.2_Missense_Mutation_p.E92K|RSRC2_uc001ucq.2_5'UTR|RSRC2_uc001ucs.2_5'UTR|RSRC2_uc001uct.2_Missense_Mutation_p.E103K|RSRC2_uc001ucu.2_Missense_Mutation_p.E151K	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	151	Ser-rich.									ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		TTCTTCCGCTCCCTACTCCTG	0.463													23	79					0	0	0	0	T	123001925	T	T	123001925	3	4	276	1	0	0	0	0	1	0	0	0	13780	864	30	2	877	2	RSRC2	12	123001925	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1585042	123001925	10849970	1304	51193											
HIP1R	9026	broad.mit.edu	37	chr12	123343423	123343423	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctctgacccgcttctccCacctggctgcggataccatc	6	9	8	18	2	2	1	0	1	2	0	4	2	2	2	4	2	3	3	4	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:123343423C>T	uc001udj.1	+	21	2148	c.2089C>T	c.(2089-2091)CAC>TAC	p.H697Y	HIP1R_uc001udk.1_5'UTR	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	697					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CCGCTTCTCCCACCTGGCTGC	0.657													16	70					0	0	0	0	T	123343423	T	T	123343423	3	4	276	1	0	0	0	0	1	0	0	0	7154	594	21	4	2171	4	HIP1R	12	123343423	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	341498	123343423	10508472	1305	51194											
MPHOSPH9	10198	broad.mit.edu	37	chr12	123687373	123687373	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	actggtcctactttcgttttGgaatgtctgatttttccaag	7	18	8	8	1	1	1	0	1	1	0	4	2	3	2	2	2	1	1	2	2	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:123687373G>A	uc001uel.2	-	6	1230	c.1123C>T	c.(1123-1125)CAA>TAA	p.Q375*	MPHOSPH9_uc010tal.1_Intron|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Intron	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	375					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		CTTTCGTTTTGGAATGTCTGA	0.403													22	134					0	0	0	0	A	123687373	A	A	123687373	4	1	276	1	0	0	0	0	0	1	0	0	9781	1357	47	4	2032	4	MPHOSPH9	12	123687373	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	343950	123687373	10164522	1306	51195											
SBNO1	55206	broad.mit.edu	37	chr12	123812357	123812357	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgttgcgtggttcagaagCacctgaaaatcccacaaatg	13	9	9	10	1	1	2	1	1	0	1	2	2	2	2	2	1	2	3	2	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:123812357C>A	uc010tap.1	-	11	1435	c.1435G>T	c.(1435-1437)GCT>TCT	p.A479S	SBNO1_uc010tao.1_Missense_Mutation_p.A478S|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.A479S|SBNO1_uc001ueu.2_Missense_Mutation_p.A478S|SBNO1_uc001uev.2_Missense_Mutation_p.A477S|SBNO1_uc009zxy.1_Missense_Mutation_p.A444S	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	479							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GGTTCAGAAGCACCTGAAAAT	0.343													13	79					0.00010058	0.000101743	1	0	A	123812357	A	A	123812357	3	1	276	1	0	0	0	0	1	0	0	0	13927	710	25	4	2830	4	SBNO1	12	123812357	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	124984	123812357	10039538	1307	51196											
DNAH10	196385	broad.mit.edu	37	chr12	124272466	124272466	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggcttcggggagggaagatCggtgggagtttgaccggaag	9	7	20	5	3	0	2	0	1	0	1	2	6	0	6	1	7	0	2	1	7	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:124272466C>T	uc001uft.3	+	10	1379	c.1354C>T	c.(1354-1356)CGG>TGG	p.R452W	DNAH10_uc010tav.1_5'Flank|DNAH10_uc010taw.1_5'Flank	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	452	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GAGGGAAGATCGGTGGGAGTT	0.577													13	25					0	0	0	0	T	124272466	T	T	124272466	3	4	276	1	0	0	0	0	1	0	0	0	4620	875	31	1	1392	1	DNAH10	12	124272466	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	460109	124272466	9579429	1308	51197											
CCDC92	80212	broad.mit.edu	37	chr12	124421792	124421792	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctgctcgccgcttcggtcgGaggcgatgggggggatgacg	4	7	20	10	6	0	1	0	1	0	0	3	4	0	3	1	6	1	3	1	6	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:124421792G>A	uc001ufw.1	-	5	956	c.809C>T	c.(808-810)TCC>TTC	p.S270F	CCDC92_uc001ufv.1_Missense_Mutation_p.S253F|CCDC92_uc001ufx.1_Missense_Mutation_p.S270F|CCDC92_uc001ufy.1_Missense_Mutation_p.S253F	NM_025140	NP_079416	Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	270											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		GCTTCGGTCGGAGGCGATGGG	0.692													7	52					0	0	0	0	A	124421792	A	A	124421792	3	1	276	1	0	0	0	0	1	0	0	0	2884	1174	41	2	190	2	CCDC92	12	124421792	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	149326	124421792	9430103	1309	51198											
ZNF664	144348	broad.mit.edu	37	chr12	124497004	124497004	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggagctcccatcttcaaattCatatgagagttcatacaggt	12	12	8	9	0	4	1	3	1	1	1	5	3	5	2	1	2	2	2	1	2	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:124497004C>T	uc001ufz.2	+	6	2143	c.313C>T	c.(313-315)CAT>TAT	p.H105Y	ZNF664_uc001uga.2_Missense_Mutation_p.H105Y|ZNF664_uc001ugb.2_Missense_Mutation_p.H105Y	NM_152437	NP_689650	Q8N3J9	ZN664_HUMAN	zinc finger protein 664	105	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.000239)|OV - Ovarian serous cystadenocarcinoma(86;0.000247)|all cancers(50;0.00155)|BRCA - Breast invasive adenocarcinoma(302;0.249)		TCTTCAAATTCATATGAGAGT	0.408													39	57					0	0	0	0	T	124497004	T	T	124497004	3	4	276	1	0	0	0	0	1	0	0	0	18139	826	29	2	315	2	ZNF664	12	124497004	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	75212	124497004	9354891	1310	51199											
NCOR2	9612	broad.mit.edu	37	chr12	124819764	124819764	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcgggctggacgagggctGgctctcaggcagcggccgca	6	4	18	13	4	1	0	1	0	1	0	2	2	1	1	1	6	2	5	1	6	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:124819764G>A	uc010tay.1	-	42	6514	c.6358C>T	c.(6358-6360)CAG>TAG	p.Q2120*	NCOR2_uc010taz.1_Nonsense_Mutation_p.Q2104*|NCOR2_uc010tax.1_Nonsense_Mutation_p.Q231*	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2121					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GACGAGGGCTGGCTCTCAGGC	0.687													11	16					0	0	0	0	A	124819764	A	A	124819764	4	1	276	1	0	0	0	0	0	1	0	0	10290	1357	47	4	1248	4	NCOR2	12	124819764	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	322760	124819764	9032131	1311	51200											
DHX37	57647	broad.mit.edu	37	chr12	125460001	125460001	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctccttggccactcgctggGacatggccacggcggccact	5	8	12	16	3	1	0	0	0	1	0	3	1	1	1	4	5	0	1	4	5	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:125460001G>A	uc001ugy.2	-	6	1043	c.944C>T	c.(943-945)TCC>TTC	p.S315F		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	315	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CACTCGCTGGGACATGGCCAC	0.647													25	55					0	0	0	0	A	125460001	A	A	125460001	3	1	276	1	0	0	0	0	1	0	0	0	4532	1174	41	2	2617	2	DHX37	12	125460001	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	640237	125460001	8391894	1312	51201											
TMEM132B	114795	broad.mit.edu	37	chr12	125834437	125834438	+	Missense_Mutation	DNP	CC	TT	TT																															tgtgtcaagatgtttgctttCcctgaggccagggaagtggc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:125834437_125834438CC>TT	uc001uhe.1	+	2	500_501	c.492_493CC>TT	c.(490-495)TTCCCT>TTTTCT	p.P165S		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	165	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TGTTTGCTTTCCCTGAGGCCAG	0.584													32	129					0	0	0	0	TT	125834438	TT	TT	125834437	3	4	276	1	0	0	0	0	1	0	0	0	16112	854	30	2	498	2	TMEM132B	12	125834437	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	374436	125834437	8017458	1313	51202											
TMEM132B	114795	broad.mit.edu	37	chr12	126138849	126138849	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaacatcccccattcccacGactgggtctggcttgggaat	8	9	10	14	1	1	0	0	0	1	0	3	2	3	1	3	3	1	2	3	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:126138849G>A	uc001uhe.1	+	9	2838	c.2830G>A	c.(2830-2832)GAC>AAC	p.D944N	TMEM132B_uc001uhf.1_Missense_Mutation_p.D456N	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	944	Cytoplasmic (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCATTCCCACGACTGGGTCTG	0.517													17	101					0	0	0	0	A	126138849	A	A	126138849	3	1	276	1	0	0	0	0	1	0	0	0	16112	1058	37	1	2864	1	TMEM132B	12	126138849	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	304412	126138849	7713046	1314	51203											
TMEM132D	121256	broad.mit.edu	37	chr12	129559115	129559115	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttgtcatctaaaaggctttCctggcctttcttcttctgca	6	17	7	11	0	5	0	1	0	4	0	6	0	6	0	2	2	1	3	2	2	2	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:129559115C>T	uc009zyl.1	-	9	2933	c.2605G>A	c.(2605-2607)GAA>AAA	p.E869K	TMEM132D_uc001uia.2_Missense_Mutation_p.E407K	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	869	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AAAAGGCTTTCCTGGCCTTTC	0.557													13	49					0	0	0	0	T	129559115	T	T	129559115	3	4	276	1	0	0	0	0	1	0	0	0	16113	864	30	2	698	2	TMEM132D	12	129559115	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3420266	129559115	4292780	1315	51204											
TMEM132D	121256	broad.mit.edu	37	chr12	129559604	129559604	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccagcaactgatggctgcttCctatggagaaaaatatgtaa	14	10	9	8	0	0	2	0	1	0	1	1	3	1	2	2	2	3	4	2	2	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:129559604C>T	uc009zyl.1	-	9	2444	c.2116G>A	c.(2116-2118)GAA>AAA	p.E706K	TMEM132D_uc001uia.2_Missense_Mutation_p.E244K	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	706	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ATGGCTGCTTCCTATGGAGAA	0.443													4	36					0	0	0	0	T	129559604	T	T	129559604	3	4	276	1	0	0	0	0	1	0	0	0	16113	869	30	2	1187	2	TMEM132D	12	129559604	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	489	129559604	4292291	1316	51205											
FZD10	11211	broad.mit.edu	37	chr12	130648775	130648775	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccggagggtgatgaagacgGgcggcgagaacacggacaag	12	3	18	8	5	0	4	0	2	0	2	1	7	1	6	1	5	1	0	1	5	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:130648775G>A	uc001uii.2	+	1	1744	c.1288G>A	c.(1288-1290)GGC>AGC	p.G430S	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	430	Cytoplasmic (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GATGAAGACGGGCGGCGAGAA	0.607													13	60					0	0	0	0	A	130648775	A	A	130648775	3	1	276	1	0	0	0	0	1	0	0	0	6163	1232	43	4	1290	4	FZD10	12	130648775	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1089171	130648775	3203120	1317	51206											
CHFR	55743	broad.mit.edu	37	chr12	133423717	133423717	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctggttgccaggtaattCtgtgacgcaaaaaaagagag	13	9	11	8	1	2	2	0	1	2	1	2	3	2	2	2	2	1	3	2	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr12:133423717C>A	uc001ulf.2	-	15	1768	c.1684_splice	c.e15-1	p.N562_splice	CHFR_uc001ulc.1_Splice_Site|CHFR_uc001ule.2_Splice_Site_p.N550_splice|CHFR_uc010tbs.1_Splice_Site_p.N561_splice|CHFR_uc001uld.2_Splice_Site_p.N521_splice|CHFR_uc010tbt.1_Splice_Site_p.N470_splice	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains						cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		CCAGGTAATTCTGTGACGCAA	0.443													8	38					3.09899e-07	3.1537e-07	1	0	A	133423717	A	A	133423717	5	1	276	1	0	0	0	0	0	0	1	0	3352	927	32	2	327	2	CHFR	12	133423717	Splice_Site	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2774942	133423717	428178	1318	51207											
TPTE2	93492	broad.mit.edu	37	chr13	20067628	20067628	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctcggttgttcctttaaattCgtttgtctgtggactagcgg	5	17	11	8	3	1	0	0	0	1	0	4	1	2	1	1	3	1	3	1	3	3	7	rs140148307		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:20067628C>T	uc001umd.2	-	3	236	c.25G>A	c.(25-27)GAA>AAA	p.E9K	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.E9K|TPTE2_uc001ume.2_Missense_Mutation_p.E9K|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	9						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CCTTTAAATTCGTTTGTCTGT	0.358													30	112					0	0	0	0	T	20067628	T	T	20067628	3	4	276	1	0	0	0	0	1	0	0	0	16498	893	31	1	1619	1	TPTE2	13	20067628	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08		20067628	95102250	1319	51208											
IFT88	8100	broad.mit.edu	37	chr13	21205187	21205187	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaagtgttggaaaaaaaGgacagtagagtgaaaagtgc	19	8	12	2	0	0	2	0	1	0	1	0	4	0	4	0	2	1	2	0	2	8	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:21205187G>A	uc001unh.2	+	18	1755	c.1359G>A	c.(1357-1359)AAG>AAA	p.K453K	IFT88_uc001uni.2_Silent_p.K444K|IFT88_uc001unj.2_Silent_p.K443K|IFT88_uc010tcq.1_Silent_p.K424K|IFT88_uc001unk.2_Silent_p.K199K|IFT88_uc001unl.1_Silent_p.K71K	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	453	TPR 5.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TGGAAAAAAAGGACAGTAGAG	0.353													23	95					0	0	0	0	A	21205187	A	A	21205187	2	1	276	1	0	0	0	0	0	0	0	1	7605	991	35	4		4	IFT88	13	21205187	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1137559	21205187	93964691	1320	51209											
LATS2	26524	broad.mit.edu	37	chr13	21563351	21563351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaagcttgggccctcgtaggGggtaccgctcagctggtggt	5	9	17	10	2	1	0	1	0	0	0	2	1	1	0	2	5	3	5	2	5	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:21563351G>A	uc009zzs.2	-	4	933	c.568C>T	c.(568-570)CCC>TCC	p.P190S	LATS2_uc001unr.3_Missense_Mutation_p.P190S	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	190					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CCCTCGTAGGGGGTACCGCTC	0.677													8	64					0	0	0	0	A	21563351	A	A	21563351	3	1	276	1	0	0	0	0	1	0	0	0	8687	1232	43	4	2718	4	LATS2	13	21563351	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	358164	21563351	93606527	1321	51210											
SACS	26278	broad.mit.edu	37	chr13	23907553	23907553	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taattttgcatcataagagaGattttcaatttttggtaaga	14	17	7	3	0	2	3	2	0	0	3	2	4	2	3	0	1	1	2	0	1	4	9			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:23907553G>A	uc001uon.2	-	10	11051	c.10462C>T	c.(10462-10464)CTC>TTC	p.L3488F	SACS_uc001uoo.2_Missense_Mutation_p.L3341F|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3488					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TCATAAGAGAGATTTTCAATT	0.308													6	31					0	0	0	0	A	23907553	A	A	23907553	3	1	276	1	0	0	0	0	1	0	0	0	13869	942	33	2	3281	2	SACS	13	23907553	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2344202	23907553	91262325	1322	51211											
SACS	26278	broad.mit.edu	37	chr13	23913425	23913425	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcacaaaatctgaatctgaGaattgagaattgttgaatga	16	13	8	4	0	3	5	1	5	2	2	3	7	3	5	0	0	0	1	0	0	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:23913425G>A	uc001uon.2	-	10	5179	c.4590C>T	c.(4588-4590)TTC>TTT	p.F1530F	SACS_uc001uoo.2_Silent_p.F1383F|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1530					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTGAATCTGAGAATTGAGAAT	0.373													10	30					0	0	0	0	A	23913425	A	A	23913425	2	1	276	1	0	0	0	0	0	0	0	1	13869	933	33	2		2	SACS	13	23913425	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5872	23913425	91256453	1323	51212											
SACS	26278	broad.mit.edu	37	chr13	23930133	23930133	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgatttggtcaccactaaaGatacaaggaacatctgtaaa	16	9	7	9	1	2	1	1	0	1	1	2	3	2	2	2	2	2	1	2	2	7	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:23930133G>A	uc001uon.2	-	8	1207	c.618C>T	c.(616-618)ATC>ATT	p.I206I	SACS_uc001uoo.2_Silent_p.I59I|SACS_uc001uop.1_5'UTR|SACS_uc001uoq.1_Silent_p.I59I	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	206					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CACCACTAAAGATACAAGGAA	0.333													5	19					0	0	0	0	A	23930133	A	A	23930133	2	1	276	1	0	0	0	0	0	0	0	1	13869	932	33	2		2	SACS	13	23930133	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	16708	23930133	91239745	1324	51213											
C1QTNF9B	387911	broad.mit.edu	37	chr13	24466110	24466110	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcctttctctcccatgggcCctgcaagccccttggggcca	4	9	11	17	0	1	0	0	0	1	0	3	0	2	0	6	4	2	1	6	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:24466110C>T	uc010tcw.1	-	3	320	c.320G>A	c.(319-321)GGG>GAG	p.G107E	MIPEP_uc001uox.3_5'Flank|PCOTH_uc001uoy.2_3'UTR|PCOTH_uc009zzx.2_3'UTR|C1QTNF9B_uc010tcv.1_Intron|C1QTNF9B_uc001uoz.1_Intron|C1QTNF9B_uc010tcx.1_Missense_Mutation_p.G107E	NM_001007537	NP_001007538	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	107	Collagen-like 2.					collagen					0						TCCCATGGGCCCTGCAAGCCC	0.577													19	73					0	0	0	0	T	24466110	T	T	24466110	3	4	276	1	0	0	0	0	1	0	0	0	1980	623	22	4	684	4	C1QTNF9B	13	24466110	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	535977	24466110	90703768	1325	51214											
C1QTNF9	338872	broad.mit.edu	37	chr13	24895224	24895224	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggccccaaggggcttgcagGgcccatgggagagaagggcc	8	4	18	11	0	0	1	0	0	0	1	0	3	0	2	4	6	1	2	4	6	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:24895224G>A	uc001upj.2	+	4	381	c.320G>A	c.(319-321)GGG>GAG	p.G107E	C1QTNF9_uc001upe.2_RNA	NM_178540	NP_848635	P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	107	Collagen-like 2.					collagen	hormone activity				0		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		GGGCTTGCAGGGCCCATGGGA	0.582													4	26					0	0	0	0	A	24895224	A	A	24895224	3	1	276	1	0	0	0	0	1	0	0	0	1979	1232	43	4	330	4	C1QTNF9	13	24895224	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	429114	24895224	90274654	1326	51215											
ATP12A	479	broad.mit.edu	37	chr13	25272805	25272805	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccttcccagctctccatcCacgagatggatgacccccac	8	9	6	18	1	1	2	0	1	1	1	5	4	4	3	6	1	1	1	6	1	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:25272805C>T	uc001upp.2	+	12	1709	c.1522C>T	c.(1522-1524)CAC>TAC	p.H508Y	ATP12A_uc010aaa.2_Missense_Mutation_p.H514Y	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	508	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GCTCTCCATCCACGAGATGGA	0.512													12	30					0	0	0	0	T	25272805	T	T	25272805	3	4	276	1	0	0	0	0	1	0	0	0	1124	594	21	4	1586	4	ATP12A	13	25272805	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	377581	25272805	89897073	1327	51216											
ATP8A2	51761	broad.mit.edu	37	chr13	26411409	26411409	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaatcacccagaatggcgaaGgcttcaacacaaaggtaaac	18	5	8	10	1	2	1	2	0	0	1	2	2	2	1	1	3	2	2	1	3	7	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:26411409G>A	uc001uqk.2	+	29	3005	c.2863G>A	c.(2863-2865)GGC>AGC	p.G955S	ATP8A2_uc010tdi.1_Missense_Mutation_p.G890S|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.G505S	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	915	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GAATGGCGAAGGCTTCAACAC	0.493													19	69					0	0	0	0	A	26411409	A	A	26411409	3	1	276	1	0	0	0	0	1	0	0	0	1195	1000	35	4	2977	4	ATP8A2	13	26411409	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1138604	26411409	88758469	1328	51217											
WASF3	10810	broad.mit.edu	37	chr13	27256961	27256961	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccgccacccccgggcccaCcacctcccccgccaggccct	4	2	7	28	3	0	0	0	0	0	0	1	0	1	0	12	2	0	0	12	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:27256961C>T	uc001uqv.2	+	9	1426	c.1201C>T	c.(1201-1203)CCA>TCA	p.P401S	WASF3_uc001uqw.2_Missense_Mutation_p.P398S	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	401	Poly-Pro.				actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CCCGGGCCCACCACCTCCCCC	0.706													20	46					0	0	0	0	T	27256961	T	T	27256961	3	4	276	1	0	0	0	0	1	0	0	0	17322	507	18	4	1227	4	WASF3	13	27256961	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	845552	27256961	87912917	1329	51218											
MTUS2	23281	broad.mit.edu	37	chr13	29599353	29599354	+	Missense_Mutation	DNP	GG	AA	AA																															ccttgacaatgaggaactgaGgaggcattctttggaaagag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:29599353_29599354GG>AA	uc001usl.3	+	1	606_607	c.548_549GG>AA	c.(547-549)AGG>AAA	p.R183K		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	173						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						GAGGAACTGAGGAGGCATTCTT	0.545													14	73					0	0	0	0	AA	29599354	AA	AA	29599353	3	1	276	1	0	0	0	0	1	0	0	0	10019	1000	35	4	550	4	MTUS2	13	29599353	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	2342392	29599353	85570525	1330	51219											
FRY	10129	broad.mit.edu	37	chr13	32776527	32776527	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctttttgtatactcaaagaAagtcgctgagcaaagaccgg	13	10	10	8	2	1	3	1	1	0	2	2	3	1	3	1	1	2	4	1	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:32776527A>G	uc001utx.2	+	31	4377	c.3881A>G	c.(3880-3882)AAA>AGA	p.K1294R	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TACTCAAAGAAAGTCGCTGAG	0.443													17	87					0	0	0	0	G	32776527	G	G	32776527	3	3	276	1	0	0	0	0	1	0	0	0	6097	14	1	5	4003	5	FRY	13	32776527	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	3177174	32776527	82393351	1331	51220											
FRY	10129	broad.mit.edu	37	chr13	32805375	32805375	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaaatcaaaattcaaagaGtgctgaacagctcactaatt	19	10	5	7	0	3	2	3	1	0	1	3	2	3	2	0	0	3	2	0	0	8	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:32805375G>A	uc001utx.2	+	41	5961	c.5465G>A	c.(5464-5466)AGT>AAT	p.S1822N	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1822					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AATTCAAAGAGTGCTGAACAG	0.353													18	51					0	0	0	0	A	32805375	A	A	32805375	3	1	276	1	0	0	0	0	1	0	0	0	6097	1029	36	4	5627	4	FRY	13	32805375	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	28848	32805375	82364503	1332	51221											
N4BP2L2	10443	broad.mit.edu	37	chr13	33016575	33016575	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttactaattgaaaggcaaacCcttgtgataatggtagctca	14	12	8	7	0	1	2	1	2	0	0	1	2	1	2	1	2	3	3	1	2	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:33016575C>T	uc010abe.1	-	7	2121	c.2099G>A	c.(2098-2100)GGG>GAG	p.G700E	N4BP2L2_uc001uug.2_Missense_Mutation_p.G583E|N4BP2L2_uc010abd.1_Missense_Mutation_p.G613E|N4BP2L2_uc001uuh.2_Missense_Mutation_p.G531E|N4BP2L2_uc001uuj.2_Missense_Mutation_p.G119E|N4BP2L2_uc010tdz.1_Missense_Mutation_p.G685E	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		AAAGGCAAACCCTTGTGATAA	0.398													6	20					0	0	0	0	T	33016575	T	T	33016575	3	4	276	1	0	0	0	0	1	0	0	0	10165	623	22	4	171	4	N4BP2L2	13	33016575	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	211200	33016575	82153303	1333	51222											
NBEA	26960	broad.mit.edu	37	chr13	35622772	35622772	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	taaacacttggtttcgtatgGatccattaaataatattaat	15	16	5	5	1	0	0	0	0	0	0	2	1	1	1	1	2	1	2	1	2	8	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:35622772G>A	uc001uvb.2	+	6	1002	c.796G>A	c.(796-798)GAT>AAT	p.D266N		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	266						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GTTTCGTATGGATCCATTAAA	0.318													11	16					0	0	0	0	A	35622772	A	A	35622772	3	1	276	1	0	0	0	0	1	0	0	0	10240	1174	41	2	814	2	NBEA	13	35622772	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2606197	35622772	79547106	1334	51223											
SMAD9	4093	broad.mit.edu	37	chr13	37446912	37446912	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggagggagtgcagagcacgGaggctgctggaaagagtcag	11	4	20	6	1	1	2	1	0	0	2	1	6	1	6	0	5	3	4	0	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:37446912G>A	uc001uvw.2	-	3	896	c.553C>T	c.(553-555)CCG>TCG	p.P185S	SMAD9_uc001uvx.2_Missense_Mutation_p.P185S|SMAD9_uc010tep.1_Missense_Mutation_p.P15S	NM_001127217	NP_001120689	O15198	SMAD9_HUMAN	SMAD family member 9 isoform a	185					BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		GCAGAGCACGGAGGCTGCTGG	0.647													12	41					0	0	0	0	A	37446912	A	A	37446912	3	1	276	1	0	0	0	0	1	0	0	0	14828	1174	41	2	870	2	SMAD9	13	37446912	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1824140	37446912	77722966	1335	51224											
POSTN	10631	broad.mit.edu	37	chr13	38160276	38160276	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgaagacattaaactacCttcggaagccactttgtctc	13	11	7	10	1	1	3	0	1	1	2	3	4	1	4	2	1	3	0	2	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:38160276C>T	uc001uwo.3	-	7	1013	c.895G>A	c.(895-897)GCT>ACT	p.A299T	POSTN_uc001uwp.3_Missense_Mutation_p.A299T|POSTN_uc001uwr.2_Missense_Mutation_p.A299T|POSTN_uc001uwq.2_Missense_Mutation_p.A299T|POSTN_uc010teu.1_Missense_Mutation_p.A299T|POSTN_uc010tev.1_Missense_Mutation_p.A299T|POSTN_uc010tew.1_Missense_Mutation_p.A299T|POSTN_uc010tex.1_Missense_Mutation_p.A214T	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	299	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		ATTAAACTACCTTCGGAAGCC	0.418													33	61					0	0	0	0	T	38160276	T	T	38160276	3	4	276	1	0	0	0	0	1	0	0	0	12314	695	24	4	1683	4	POSTN	13	38160276	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	713364	38160276	77009602	1336	51225											
MTRF1	9617	broad.mit.edu	37	chr13	41826834	41826834	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attgccagtgtttatagcacGaataattctggtacatgtca	12	14	8	7	1	2	0	1	0	1	0	2	1	2	0	1	1	3	3	1	1	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:41826834G>A	uc001uxx.2	-	7	1114	c.644C>T	c.(643-645)TCG>TTG	p.S215L	MTRF1_uc001uxy.2_Missense_Mutation_p.S215L|MTRF1_uc001uxz.2_Missense_Mutation_p.S51L|MTRF1_uc010tff.1_Missense_Mutation_p.S228L|MTRF1_uc001uyc.1_Missense_Mutation_p.S215L	NM_004294	NP_004285	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	215					regulation of translational termination	mitochondrion	translation release factor activity, codon specific				0		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		TTTATAGCACGAATAATTCTG	0.333													12	29					0	0	0	0	A	41826834	A	A	41826834	3	1	276	1	0	0	0	0	1	0	0	0	10012	1059	37	1	717	1	MTRF1	13	41826834	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3666558	41826834	73343044	1337	51226											
DGKH	160851	broad.mit.edu	37	chr13	42733462	42733462	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaaataactgtaaatggaCtaccctggcctccatcggga	14	8	8	11	1	0	0	0	0	0	0	2	2	1	2	3	3	3	1	3	3	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:42733462C>T	uc001uyl.1	+	6	704	c.683C>T	c.(682-684)ACT>ATT	p.T228I	DGKH_uc010tfh.1_Missense_Mutation_p.T228I|DGKH_uc001uym.1_Missense_Mutation_p.T228I|DGKH_uc010tfi.1_Intron|DGKH_uc010tfj.1_Missense_Mutation_p.T83I|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.T83I|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	228					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		TGTAAATGGACTACCCTGGCC	0.398													5	22					0	0	0	0	T	42733462	T	T	42733462	3	4	276	1	0	0	0	0	1	0	0	0	4492	565	20	4	705	4	DGKH	13	42733462	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	906628	42733462	72436416	1338	51227											
SPERT	220082	broad.mit.edu	37	chr13	46287594	46287594	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaactgccgcctgcagtctcCctacttctccccatccgcct	5	10	6	20	2	2	0	0	0	2	0	5	1	3	0	7	0	4	1	7	0	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:46287594C>T	uc001van.1	+	3	514	c.434C>T	c.(433-435)CCC>CTC	p.P145L	SPERT_uc001vao.2_Missense_Mutation_p.P109L	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	145						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CTGCAGTCTCCCTACTTCTCC	0.617													12	49					0	0	0	0	T	46287594	T	T	46287594	3	4	276	1	0	0	0	0	1	0	0	0	15105	623	22	4	444	4	SPERT	13	46287594	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3554132	46287594	68882284	1339	51228											
SIAH3	283514	broad.mit.edu	37	chr13	46357846	46357846	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaaagtggtggccaaggcagGagtgcatgatgatccaatca	13	7	14	7	0	1	2	1	2	0	0	2	4	2	3	2	4	1	2	2	4	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:46357846G>A	uc001vap.2	-	2	564	c.482C>T	c.(481-483)TCC>TTC	p.S161F		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	161					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						GCCAAGGCAGGAGTGCATGAT	0.597													7	23					0	0	0	0	A	46357846	A	A	46357846	3	1	276	1	0	0	0	0	1	0	0	0	14366	1174	41	2	331	2	SIAH3	13	46357846	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	70252	46357846	68812032	1340	51229											
LCP1	3936	broad.mit.edu	37	chr13	46701838	46701838	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acactcttgctccaatttttCgggccatagagatggcatat	10	13	8	10	1	1	1	0	0	1	1	3	2	2	1	2	2	1	2	2	2	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:46701838C>T	uc001vaz.3	-	16	1898	c.1772G>A	c.(1771-1773)CGA>CAA	p.R591Q	LCP1_uc010ack.2_Missense_Mutation_p.R160Q|LCP1_uc001vay.3_Missense_Mutation_p.R188Q|LCP1_uc001vba.3_Missense_Mutation_p.R591Q	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	591	Actin-binding 2.|CH 4.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TCCAATTTTTCGGGCCATAGA	0.488			T	BCL6	NHL 								30	130					0	0	0	0	T	46701838	T	T	46701838	3	4	276	1	0	0	0	0	1	0	0	0	8731	884	31	1	115	1	LCP1	13	46701838	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	343992	46701838	68468040	1341	51230											
C13orf18	80183	broad.mit.edu	37	chr13	46918956	46918956	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	attcacaaataaagccctttCcttgacacagctgtaaaaga	16	10	5	10	0	1	2	1	1	0	1	2	2	2	2	2	0	2	2	2	0	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:46918956C>T	uc010acl.2	-	14	2401	c.1796G>A	c.(1795-1797)GGA>GAA	p.G599E	C13orf18_uc010tfy.1_Missense_Mutation_p.G122E|C13orf18_uc001vbf.3_Missense_Mutation_p.G532E|C13orf18_uc001vbg.3_Missense_Mutation_p.G327E|C13orf18_uc010tfz.1_Missense_Mutation_p.G442E|C13orf18_uc010acm.2_Missense_Mutation_p.G464E|C13orf18_uc010acn.2_Missense_Mutation_p.G384E|C13orf18_uc001vbe.3_Missense_Mutation_p.E548K|C13orf18_uc001vbh.3_Missense_Mutation_p.G599E|C13orf18_uc001vbi.3_Missense_Mutation_p.G442E	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	599											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		AAAGCCCTTTCCTTGACACAG	0.338													3	20					0	0	0	0	T	46918956	T	T	46918956	3	4	276	1	0	0	0	0	1	0	0	0	1726	855	30	2	200	2	C13orf18	13	46918956	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	217118	46918956	68250922	1342	51231											
KPNA3	3839	broad.mit.edu	37	chr13	50285056	50285056	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacttcctgatggctcagaaGgggcacaagaaagggcacaa	14	5	13	9	0	1	3	1	1	0	2	2	4	2	3	1	4	0	3	1	4	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:50285056G>A	uc001vdj.2	-	11	1289	c.874C>T	c.(874-876)CTT>TTT	p.L292F		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3	292	ARM 6.				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		TGGCTCAGAAGGGGCACAAGA	0.378													12	38					0	0	0	0	A	50285056	A	A	50285056	3	1	276	1	0	0	0	0	1	0	0	0	8470	1000	35	4	719	4	KPNA3	13	50285056	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3366100	50285056	64884822	1343	51232											
KPNA3	3839	broad.mit.edu	37	chr13	50299560	50299560	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatttacttactagactgcAcaacagcttgagtctgtgca	12	12	8	9	0	1	2	0	1	1	1	1	3	1	2	0	0	6	3	0	0	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:50299560A>C	uc001vdj.2	-	7	876	c.461T>G	c.(460-462)GTG>GGG	p.V154G		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3	154	ARM 3.|NLS binding site (major) (By similarity).			V -> G (in Ref. 3; AAB87693).	interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		ACTAGACTGCACAACAGCTTG	0.338													8	36					0	0	0	0	C	50299560	C	C	50299560	3	2	276	1	0	0	0	0	1	0	0	0	8470	159	6	5	1148	5	KPNA3	13	50299560	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	14504	50299560	64870318	1344	51233											
FAM124A	220108	broad.mit.edu	37	chr13	51826338	51826338	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggaacaagatcctcctacagGtactggggggacgcctgtct	9	8	13	11	1	1	1	0	0	1	1	3	3	3	3	3	5	3	1	3	5	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:51826338G>A	uc001vfg.1	+	3	965	c.834_splice	c.e3+1	p.Q278_splice	FAM124A_uc001vfe.2_Missense_Mutation_p.V279I|FAM124A_uc001vff.1_Splice_Site_p.Q314_splice	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108											central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		CCTCCTACAGGTACTGGGGGG	0.562													7	17					0	0	0	0	A	51826338	A	A	51826338	5	1	276	1	0	0	0	0	0	0	1	0	5453	1275	44	4	957	4	FAM124A	13	51826338	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1526778	51826338	63343540	1345	51234											
TDRD3	81550	broad.mit.edu	37	chr13	61102891	61102891	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagcagatcaggaaaaggtcCctcctttgcagaggcaaaag	15	6	11	9	0	1	2	1	0	0	2	3	3	3	3	2	3	2	3	2	3	5	1	rs138120427		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:61102891C>T	uc001via.2	+	11	2041	c.1253C>T	c.(1252-1254)CCC>CTC	p.P418L	TDRD3_uc010aef.2_Missense_Mutation_p.P243L|TDRD3_uc001vhz.3_Missense_Mutation_p.P418L|TDRD3_uc010aeg.2_Missense_Mutation_p.P511L|TDRD3_uc001vib.3_Missense_Mutation_p.P417L	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	418					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		GGAAAAGGTCCCTCCTTTGCA	0.363													15	75					0	0	0	0	T	61102891	T	T	61102891	3	4	276	1	0	0	0	0	1	0	0	0	15798	623	22	4	1574	4	TDRD3	13	61102891	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	9276553	61102891	54066987	1346	51235											
PCDH20	64881	broad.mit.edu	37	chr13	61986527	61986527	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcccagaaaatatgaaacttGgcctctctcctcgctgtcgg	9	11	8	13	2	1	2	0	1	1	1	6	2	3	2	3	2	1	1	3	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:61986527G>A	uc001vid.3	-	2	2069	c.1705C>T	c.(1705-1707)CAA>TAA	p.Q569*	PCDH20_uc010thj.1_Nonsense_Mutation_p.Q569*	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	542	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TATGAAACTTGGCCTCTCTCC	0.443													19	83					0	0	0	0	A	61986527	A	A	61986527	4	1	276	1	0	0	0	0	0	1	0	0	11569	1357	47	4	1154	4	PCDH20	13	61986527	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	883636	61986527	53183351	1347	51236											
PIBF1	10464	broad.mit.edu	37	chr13	73401257	73401257	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaagtgaattatcaaaagagGtaagcttataattagagtca	18	11	9	3	0	2	3	2	1	0	2	2	4	2	3	0	1	1	2	0	1	9	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:73401257G>A	uc001vjc.2	+	7	1220	c.915_splice	c.e7+1	p.E305_splice	PIBF1_uc001vja.1_Splice_Site_p.E305_splice|PIBF1_uc010aeo.1_Splice_Site|PIBF1_uc001vjb.2_Splice_Site_p.E305_splice|PIBF1_uc010aep.2_Intron	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1							centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		ATCAAAAGAGGTAAGCTTATA	0.313													12	31					0	0	0	0	A	73401257	A	A	73401257	5	1	276	1	0	0	0	0	0	0	1	0	11934	1275	44	4	938	4	PIBF1	13	73401257	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	11414730	73401257	41768621	1348	51237											
KLF12	11278	broad.mit.edu	37	chr13	74420074	74420074	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcaccgactgtaccaccacgGggatgcggtgaacatgactc	10	6	12	13	3	0	2	0	2	0	0	1	4	0	3	3	3	3	2	3	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:74420074G>A	uc001vjf.2	-	4	782	c.560C>T	c.(559-561)CCC>CTC	p.P187L	KLF12_uc010aeq.2_Missense_Mutation_p.P187L|KLF12_uc001vjg.3_Missense_Mutation_p.P187L	NM_007249	NP_009180	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	187					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		TACCACCACGGGGATGCGGTG	0.507													18	67					0	0	0	0	A	74420074	A	A	74420074	3	1	276	1	0	0	0	0	1	0	0	0	8379	1232	43	4	668	4	KLF12	13	74420074	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1018817	74420074	40749804	1349	51238											
TBC1D4	9882	broad.mit.edu	37	chr13	75898414	75898414	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggacagtctacctgaattCtggtaaaagcttttcaggaa	12	11	11	7	0	3	1	1	1	2	0	3	3	3	3	1	4	2	2	1	4	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:75898414C>T	uc001vjl.1	-	11	2504	c.2157G>A	c.(2155-2157)CAG>CAA	p.Q719Q	TBC1D4_uc010aer.2_Silent_p.Q719Q|TBC1D4_uc010aes.2_Intron	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	719	Ser-rich.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		TACCTGAATTCTGGTAAAAGC	0.428													15	48					0	0	0	0	T	75898414	T	T	75898414	2	4	276	1	0	0	0	0	0	0	0	1	15688	912	32	2		2	TBC1D4	13	75898414	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1478340	75898414	39271464	1350	51239											
FBXL3	26224	broad.mit.edu	37	chr13	77581856	77581856	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgcaagtaacaactcatcActcaataagtggtagttcag	16	10	7	8	0	4	0	4	0	0	0	4	0	4	0	0	1	3	4	0	1	7	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:77581856A>C	uc001vkd.2	-	5	1082	c.711T>G	c.(709-711)AGT>AGG	p.S237R		NM_012158	NP_036290	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	237	LRR 4.				regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)		ACAACTCATCACTCAATAAGT	0.378													9	48					0	0	0	0	C	77581856	C	C	77581856	3	2	276	1	0	0	0	0	1	0	0	0	5752	156	6	5	579	5	FBXL3	13	77581856	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1683442	77581856	37588022	1351	51240											
MYCBP2	23077	broad.mit.edu	37	chr13	77670523	77670523	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ataccagataccaagtgcttCctcctatgccaccatcacca	12	9	4	16	0	1	1	1	0	0	1	3	1	3	1	7	0	4	1	7	0	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:77670523C>T	uc001vkf.2	-	58	9855	c.9764G>A	c.(9763-9765)GGA>GAA	p.G3255E	MYCBP2_uc010aev.2_Missense_Mutation_p.G2659E	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3255	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CCAAGTGCTTCCTCCTATGCC	0.463													28	73					0	0	0	0	T	77670523	T	T	77670523	3	4	276	1	0	0	0	0	1	0	0	0	10071	855	30	2	4266	2	MYCBP2	13	77670523	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	88667	77670523	37499355	1352	51241											
SLAIN1	122060	broad.mit.edu	37	chr13	78335135	78335135	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aacacaggaatccccacaccGaacaaagctgcagcttctgg	14	5	8	14	1	1	0	0	0	1	0	2	2	2	1	3	2	5	3	3	2	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:78335135G>A	uc010thy.1	+	6	1138	c.1095G>A	c.(1093-1095)CCG>CCA	p.P365P	SLAIN1_uc001vkk.1_Silent_p.P288P|SLAIN1_uc001vkl.1_Silent_p.P244P|SLAIN1_uc010thz.1_Silent_p.P243P|SLAIN1_uc010aex.1_Silent_p.P130P|SLAIN1_uc010aey.1_Silent_p.P130P|SLAIN1_uc001vkm.2_Silent_p.P244P	NM_144595	NP_653196	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1 B	507										ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)		TCCCCACACCGAACAAAGCTG	0.488													19	60					0	0	0	0	A	78335135	A	A	78335135	2	1	276	1	0	0	0	0	0	0	0	1	14430	1045	37	1		1	SLAIN1	13	78335135	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	664612	78335135	36834743	1353	51242											
EDNRB	1910	broad.mit.edu	37	chr13	78477474	78477474	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccaattcctttaattctactCcaagaagcaacagctcgata	14	11	4	12	1	1	1	0	0	1	1	4	2	3	1	3	0	4	2	3	0	7	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:78477474C>T	uc001vko.2	-	3	876	c.618G>A	c.(616-618)TGG>TGA	p.W206*	EDNRB_uc001vkq.1_Nonsense_Mutation_p.W206*|uc001vkn.1_Intron|EDNRB_uc010aez.1_Nonsense_Mutation_p.W206*|EDNRB_uc001vkp.1_Nonsense_Mutation_p.W289*	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	206	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	TAATTCTACTCCAAGAAGCAA	0.368													24	132					0	0	0	0	T	78477474	T	T	78477474	4	4	276	1	0	0	0	0	0	1	0	0	4942	856	30	2	851	2	EDNRB	13	78477474	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	142339	78477474	36692404	1354	51243											
RNF219	79596	broad.mit.edu	37	chr13	79191069	79191069	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctccctttgccatctgcaGaaagtgctgtctggcaaatg	8	12	10	11	0	2	1	0	0	2	1	3	1	3	1	2	1	4	4	2	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:79191069G>A	uc001vkw.1	-	6	886	c.827C>T	c.(826-828)TCT>TTT	p.S276F	uc001vku.1_RNA|RNF219_uc010afb.1_Missense_Mutation_p.S86F|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	276							zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		GCCATCTGCAGAAAGTGCTGT	0.443													41	48					0	0	0	0	A	79191069	A	A	79191069	3	1	276	1	0	0	0	0	1	0	0	0	13547	942	33	2	1357	2	RNF219	13	79191069	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	713595	79191069	35978809	1355	51244											
SPRY2	10253	broad.mit.edu	37	chr13	80911432	80911432	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggaggagaaggatgatcCtagcagtctctgttcagagg	10	8	14	9	1	2	3	1	1	1	2	4	6	3	5	2	4	1	2	2	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:80911432C>T	uc001vli.2	-	2	1387	c.409G>A	c.(409-411)GGA>AGA	p.G137R	SPRY2_uc001vlj.2_Missense_Mutation_p.G137R	NM_005842	NP_005833	O43597	SPY2_HUMAN	sprouty 2	137					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			ovary(1)|lung(1)	2	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		AAGGATGATCCTAGCAGTCTC	0.562													14	54					0	0	0	0	T	80911432	T	T	80911432	3	4	276	1	0	0	0	0	1	0	0	0	15172	690	24	4	542	4	SPRY2	13	80911432	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1720363	80911432	34258446	1356	51245											
DNAJC3	5611	broad.mit.edu	37	chr13	96416196	96416196	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctatttgatagaggaaaTgtatgatgaaggtaaatctt	14	13	11	3	0	1	4	0	3	1	1	1	5	1	5	1	3	0	2	1	3	7	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:96416196T>G	uc001vmq.2	+	9	1172	c.1064T>G	c.(1063-1065)ATG>AGG	p.M355R	DNAJC3_uc001vmr.2_Missense_Mutation_p.M304R	NM_006260	NP_006251	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	355	TPR 9.				protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding				0	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			ATAGAGGAAATGTATGATGAA	0.353													29	49					0	0	0	0	G	96416196	G	G	96416196	3	3	276	1	0	0	0	0	1	0	0	0	4669	1464	51	5	1098	5	DNAJC3	13	96416196	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	15504764	96416196	18753682	1357	51246											
FAM155A	728215	broad.mit.edu	37	chr13	108518049	108518049	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccttacagtcttcaggacagGatttcaccgagtactcctcc	9	11	7	14	1	3	0	2	0	1	0	5	3	5	2	4	2	2	1	4	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:108518049G>A	uc001vql.2	-	1	1412	c.896C>T	c.(895-897)TCC>TTC	p.S299F		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	299						integral to membrane	binding			skin(1)	1						TTCAGGACAGGATTTCACCGA	0.473													20	68					0	0	0	0	A	108518049	A	A	108518049	3	1	276	1	0	0	0	0	1	0	0	0	5493	1174	41	2	492	2	FAM155A	13	108518049	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	12101853	108518049	6651829	1358	51247											
MYO16	23026	broad.mit.edu	37	chr13	109459108	109459108	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagacctcaacatagtagatGatcagtactggactcccctc	12	9	8	12	0	2	3	2	1	0	2	4	5	3	4	3	1	2	2	3	1	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:109459108G>A	uc001vqt.1	+	7	883	c.757G>A	c.(757-759)GAT>AAT	p.D253N	MYO16_uc010agk.1_Missense_Mutation_p.D275N|MYO16_uc001vqu.1_Missense_Mutation_p.D53N	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	253					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CATAGTAGATGATCAGTACTG	0.413													21	48					0	0	0	0	A	109459108	A	A	109459108	3	1	276	1	0	0	0	0	1	0	0	0	10117	1290	45	2	779	2	MYO16	13	109459108	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	941059	109459108	5710770	1359	51248											
F10	2159	broad.mit.edu	37	chr13	113783849	113783849	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaagagatgaagaaaggaCacctcgaaagagagtgcatg	17	6	13	5	1	0	5	0	2	0	3	1	9	0	6	1	1	1	1	1	1	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:113783849C>A	uc001vsx.2	+	2	211	c.154C>A	c.(154-156)CAC>AAC	p.H52N	F10_uc010agq.1_RNA|F10_uc001vsy.2_Missense_Mutation_p.H52N|F10_uc001vsz.2_Missense_Mutation_p.H52N	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	52	Gla.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAAGAAAGGACACCTCGAAAG	0.567													18	65					5.3912e-06	5.47322e-06	1	0	A	113783849	A	A	113783849	3	1	276	1	0	0	0	0	1	0	0	0	5361	478	17	4	160	4	F10	13	113783849	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4324741	113783849	1386029	1360	51249											
PCID2	55795	broad.mit.edu	37	chr13	113852537	113852537	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcaaacatttcatcataaggGggttccaagacttgttgaca	13	11	9	8	0	2	2	2	1	0	1	3	2	3	2	1	2	1	3	1	2	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr13:113852537G>A	uc010tju.1	-	3	249	c.168C>T	c.(166-168)CCC>CCT	p.P56P	PCID2_uc010tjv.1_Silent_p.P56P|PCID2_uc010tjw.1_Silent_p.P56P|PCID2_uc001vte.2_5'UTR|PCID2_uc001vtd.2_5'UTR|PCID2_uc001vtf.2_5'UTR|PCID2_uc001vtg.1_RNA	NM_001127203	NP_001120675	Q5JVF3	PCID2_HUMAN	PCI domain containing 2	56					negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)			CATCATAAGGGGGTTCCAAGA	0.368													22	144					0	0	0	0	A	113852537	A	A	113852537	2	1	276	1	0	0	0	0	0	0	0	1	11633	1219	43	4		4	PCID2	13	113852537	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	68688	113852537	1317341	1361	51250											
POTEG	404785	broad.mit.edu	37	chr14	19553775	19553775	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagagcaaagtgggcccttGgggagactacgacgacagcg	12	4	15	10	3	0	2	0	0	0	2	0	5	0	2	1	3	3	1	1	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:19553775G>C	uc001vuz.1	+	1	411	c.359G>C	c.(358-360)TGG>TCG	p.W120S	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	120										ovary(1)	1						GTGGGCCCTTGGGGAGACTAC	0.602													54	680					0	0	0	0	C	19553775	C	C	19553775	3	2	276	1	0	0	0	0	1	0	0	0	12321	1357	47	4	361	4	POTEG	14	19553775	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08		19553775	87795765	1362	51251											
OR4N2	390429	broad.mit.edu	37	chr14	20296255	20296255	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctttctggggcttctggcCtcctatgcagtcattctttg	3	17	10	11	0	4	0	1	0	3	0	5	0	5	0	2	3	2	3	2	3	1	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:20296255C>T	uc010tkv.1	+	1	648	c.648C>T	c.(646-648)GCC>GCT	p.A216A		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGCTTCTGGCCTCCTATGCAG	0.493													25	117					0	0	0	0	T	20296255	T	T	20296255	2	4	276	1	0	0	0	0	0	0	0	1	11131	668	24	4		4	OR4N2	14	20296255	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	742480	20296255	87053285	1363	51252											
OR4K2	390431	broad.mit.edu	37	chr14	20344870	20344870	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgctctcgtggtggcttcCtggattatgggagttatgca	5	15	14	7	1	1	0	0	0	1	0	3	2	2	2	1	4	2	5	1	4	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:20344870C>T	uc001vwh.1	+	1	444	c.444C>T	c.(442-444)TCC>TCT	p.S148S		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGGTGGCTTCCTGGATTATGG	0.468													46	246					0	0	0	0	T	20344870	T	T	20344870	2	4	276	1	0	0	0	0	0	0	0	1	11126	668	24	4		4	OR4K2	14	20344870	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	48615	20344870	87004670	1364	51253											
OR4K15	81127	broad.mit.edu	37	chr14	20443771	20443771	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaatgagacaaatcattctCgggtgacagaatttgtgttg	12	13	11	5	1	2	4	1	3	1	2	3	5	2	4	0	1	0	1	0	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:20443771C>A	uc010tkx.1	+	1	94	c.94C>A	c.(94-96)CGG>AGG	p.R32R		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	32	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAATCATTCTCGGGTGACAGA	0.403													46	91					8.00217e-19	8.29661e-19	1	0	A	20443771	A	A	20443771	2	1	276	1	0	0	0	0	0	0	0	1	11124	875	31	3		3	OR4K15	14	20443771	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	98901	20443771	86905769	1365	51254											
OR4K15	81127	broad.mit.edu	37	chr14	20443795	20443795	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgacagaatttgtgttgctgGgactgtctagttcaagggag	9	13	14	5	0	2	2	1	1	1	1	2	4	2	4	0	2	1	3	0	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:20443795G>A	uc010tkx.1	+	1	118	c.118G>A	c.(118-120)GGA>AGA	p.G40R		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	40	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTGTTGCTGGGACTGTCTAG	0.403													61	119					0	0	0	0	A	20443795	A	A	20443795	3	1	276	1	0	0	0	0	1	0	0	0	11124	1233	43	4	120	4	OR4K15	14	20443795	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	24	20443795	86905745	1366	51255											
OR4K15	81127	broad.mit.edu	37	chr14	20444538	20444539	+	Missense_Mutation	DNP	CA	AG	AG																															atctatgtgtggcccttcagCagttactcagttgacaaagt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:20444538_20444539CA>AG	uc010tkx.1	+	1	861_862	c.861_862CA>AG	c.(859-864)AGCAGT>AGAGGT	p.287_288SS>RG		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	287_288	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGCCCTTCAGCAGTTACTCAGT	0.45													25	77					0	0	0	0	AG	20444539	AG	AG	20444538	3	1	276	1	0	0	0	0	1	0	0	0	11124	709	25	4	863	4	OR4K15	14	20444538	Missense_Mutation	DNP	CA	TCGA-D6-6516-01A-11D-1870-08	743	20444538	86905002	1367	51256											
OR4K14	122740	broad.mit.edu	37	chr14	20482831	20482831	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacagaagaagctgtctacCtcattggggccacagtaagg	12	8	11	10	0	3	2	2	0	1	2	3	2	3	2	2	3	2	2	2	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:20482831C>T	uc010tky.1	-	1	522	c.522G>A	c.(520-522)GAG>GAA	p.E174E		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AGCTGTCTACCTCATTGGGGC	0.483													20	44					0	0	0	0	T	20482831	T	T	20482831	2	4	276	1	0	0	0	0	0	0	0	1	11123	680	24	4		4	OR4K14	14	20482831	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	38293	20482831	86866709	1368	51257											
OR4K13	390433	broad.mit.edu	37	chr14	20502834	20502834	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaccacagagaatcccaaGaagaataaaatctgaagatt	21	6	7	7	0	1	6	0	1	1	5	2	7	2	6	2	0	0	0	2	0	8	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:20502834G>A	uc010tkz.1	-	1	84	c.84C>T	c.(82-84)TTC>TTT	p.F28F		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AGAATCCCAAGAAGAATAAAA	0.403													14	43					0	0	0	0	A	20502834	A	A	20502834	2	1	276	1	0	0	0	0	0	0	0	1	11122	933	33	2		2	OR4K13	14	20502834	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	20003	20502834	86846706	1369	51258											
TEP1	7011	broad.mit.edu	37	chr14	20845880	20845880	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agggaacccaggtgcccacgGggccgacccagagaccctga	10	2	14	15	2	0	2	0	1	0	1	0	5	0	3	5	4	2	0	5	4	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:20845880G>A	uc001vxe.2	-	40	5794	c.5754C>T	c.(5752-5754)CCC>CCT	p.P1918P	TEP1_uc010ahk.2_Silent_p.P1261P|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.P1810P|TEP1_uc010tlh.1_Silent_p.P256P	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1918	WD 7.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGTGCCCACGGGGCCGACCCA	0.577													14	70					0	0	0	0	A	20845880	A	A	20845880	2	1	276	1	0	0	0	0	0	0	0	1	15825	1219	43	4		4	TEP1	14	20845880	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	343046	20845880	86503660	1370	51259											
TPPP2	122664	broad.mit.edu	37	chr14	21499262	21499262	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaaagggaagagtccagatGaagtcctggagaacatttat	15	9	11	6	0	1	4	1	1	0	3	3	6	3	5	2	2	1	0	2	2	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:21499262G>A	uc001vzh.2	+	3	453	c.265G>A	c.(265-267)GAA>AAA	p.E89K	NDRG2_uc010tll.1_Intron	NM_173846	NP_776245	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family	89						cytoplasm					0	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GAGTCCAGATGAAGTCCTGGA	0.537													11	70					0	0	0	0	A	21499262	A	A	21499262	3	1	276	1	0	0	0	0	1	0	0	0	16481	1291	45	2	271	2	TPPP2	14	21499262	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	653382	21499262	85850278	1371	51260											
FLJ10357	55701	broad.mit.edu	37	chr14	21547156	21547156	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agagcagcggcagtgcctgcGgcgactccagcaggtgagcc	8	4	16	13	3	0	2	0	1	0	1	1	3	1	2	3	3	6	3	3	3	0	0	rs143586197		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:21547156G>A	uc001vzp.2	+	11	2389	c.2360G>A	c.(2359-2361)CGG>CAG	p.R787Q	FLJ10357_uc001vzo.1_5'UTR|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_Missense_Mutation_p.R73Q	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	787					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		CAGTGCCTGCGGCGACTCCAG	0.602													15	27					0	0	0	0	A	21547156	A	A	21547156	3	1	276	1	0	0	0	0	1	0	0	0	5958	1116	39	1	2402	1	FLJ10357	14	21547156	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	47894	21547156	85802384	1372	51261											
MMP14	4323	broad.mit.edu	37	chr14	23312536	23312536	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgagcattccagtgacccCtcggccatcatggcaccctt	7	9	8	17	2	1	1	1	1	0	0	4	2	2	1	5	2	1	2	5	2	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:23312536C>T	uc001whc.2	+	5	993	c.759C>T	c.(757-759)CCC>CCT	p.P253P		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	253	Extracellular (Potential).					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		CCAGTGACCCCTCGGCCATCA	0.577													23	80					0	0	0	0	T	23312536	T	T	23312536	2	4	276	1	0	0	0	0	0	0	0	1	9706	668	24	4		4	MMP14	14	23312536	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1765380	23312536	84037004	1373	51262											
RBM23	55147	broad.mit.edu	37	chr14	23374831	23374831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacctgactgggctcttctCtctgaaatgaggactcttac	8	12	8	13	0	4	3	0	3	4	0	5	4	4	4	2	2	1	1	2	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:23374831C>T	uc001whg.2	-	6	638	c.439G>A	c.(439-441)GAG>AAG	p.E147K	RBM23_uc001whh.2_Missense_Mutation_p.E131K|RBM23_uc001whi.2_Intron|RBM23_uc010tne.1_5'UTR|RBM23_uc001whj.2_Intron|RBM23_uc001whk.1_Missense_Mutation_p.E147K	NM_001077351	NP_001070819	Q86U06	RBM23_HUMAN	RNA binding motif protein 23 isoform 1	147					mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		GGGCTCTTCTCTCTGAAATGA	0.383													26	78					0	0	0	0	T	23374831	T	T	23374831	3	4	276	1	0	0	0	0	1	0	0	0	13188	922	32	2	916	2	RBM23	14	23374831	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	62295	23374831	83974709	1374	51263											
C14orf93	60686	broad.mit.edu	37	chr14	23465357	23465357	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagcttggttccattttctgGtcctgtctctggggttgccc	2	16	11	12	0	2	0	0	0	2	0	5	0	4	0	3	4	2	3	3	4	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:23465357G>A	uc001wib.1	-	3	1028	c.718C>T	c.(718-720)CCA>TCA	p.P240S	C14orf93_uc001wic.1_Missense_Mutation_p.P60S|C14orf93_uc001wid.1_Missense_Mutation_p.P240S|C14orf93_uc001wig.2_Missense_Mutation_p.P240S|C14orf93_uc001wih.2_Missense_Mutation_p.P240S|C14orf93_uc001wie.2_Missense_Mutation_p.P240S|C14orf93_uc001wia.3_Missense_Mutation_p.P240S|C14orf93_uc001wif.2_Missense_Mutation_p.P60S	NM_021944	NP_068763	Q9H972	CN093_HUMAN	hypothetical protein LOC60686 precursor	240						extracellular region				ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		CCATTTTCTGGTCCTGTCTCT	0.602													12	96					0	0	0	0	A	23465357	A	A	23465357	3	1	276	1	0	0	0	0	1	0	0	0	1788	1261	44	4	918	4	C14orf93	14	23465357	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	90526	23465357	83884183	1375	51264											
PABPN1	8106	broad.mit.edu	37	chr14	23793208	23793209	+	Missense_Mutation	DNP	GT	AA	AA																															agttctcagacaaagagtcaGtgaggacttccttggcctta																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:23793208_23793209GT>AA	uc001wjk.2	+	5	1958_1959	c.676_677GT>AA	c.(676-678)GTG>AAG	p.V226K	PABPN1_uc001wjh.3_Missense_Mutation_p.V253K|PABPN1_uc001wjj.2_Missense_Mutation_p.V226K	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	226	Necessary for homooligomerization.|RRM.				modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CAAAGAGTCAGTGAGGACTTCC	0.332													10	65					0	0	0	0	AA	23793209	AA	AA	23793208	3	1	276	1	0	0	0	0	1	0	0	0	11422	1029	36	4	694	4	PABPN1	14	23793208	Missense_Mutation	DNP	GT	TCGA-D6-6516-01A-11D-1870-08	327851	23793208	83556332	1376	51265											
MYH6	4624	broad.mit.edu	37	chr14	23855233	23855233	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctccaccacggcacgcagCtcctccagctcagcctgcag	7	6	9	19	2	1	0	1	0	0	0	4	0	4	0	5	1	5	6	5	1	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:23855233C>T	uc001wjv.2	-	34	5134	c.5067G>A	c.(5065-5067)GAG>GAA	p.E1689E		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1689	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CGGCACGCAGCTCCTCCAGCT	0.642													12	33					0	0	0	0	T	23855233	T	T	23855233	2	4	276	1	0	0	0	0	0	0	0	1	10091	796	28	4		4	MYH6	14	23855233	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	62025	23855233	83494307	1377	51266											
DHRS4L2	317749	broad.mit.edu	37	chr14	24459498	24459498	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggccacgctgcagggggAggggctgagcgtgacgggca	6	4	22	9	3	0	2	0	2	0	0	0	3	0	3	1	7	2	4	1	7	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:24459498A>G	uc001wli.3	+	2	366	c.236A>G	c.(235-237)GAG>GGG	p.E79G	DHRS4_uc001wlc.3_Intron|DHRS4L2_uc001wld.3_Intron|DHRS4L2_uc001wle.3_Intron|DHRS4L2_uc001wlg.3_RNA|DHRS4L2_uc001wlh.3_RNA|DHRS4L2_uc010tnt.1_Missense_Mutation_p.E77G	NM_198083	NP_932349	D5KJA1	D5KJA1_HUMAN	dehydrogenase/reductase (SDR family) member 4	51							binding|oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00962)		CTGCAGGGGGAGGGGCTGAGC	0.687													3	64					0	0	0	0	G	24459498	G	G	24459498	3	3	276	1	0	0	0	0	1	0	0	0	4516	304	11	5	242	5	DHRS4L2	14	24459498	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	604265	24459498	82890042	1378	51267											
REC8	9985	broad.mit.edu	37	chr14	24647314	24647314	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaggaggcccccagtcccCccacctcctcgccgccgccg	5	3	10	23	4	0	1	0	0	0	1	3	2	2	2	10	2	0	0	10	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:24647314C>T	uc001wmr.2	+	14	1309	c.882C>T	c.(880-882)CCC>CCT	p.P294P	REC8_uc001wms.2_Silent_p.P294P	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	294	Pro-rich.|Glu-rich.				mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		CCCCAGTCCCCCCACCTCCTC	0.612													10	67					0	0	0	0	T	24647314	T	T	24647314	2	4	276	1	0	0	0	0	0	0	0	1	13264	610	22	4		4	REC8	14	24647314	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	187816	24647314	82702226	1379	51268											
NYNRIN	57523	broad.mit.edu	37	chr14	24884780	24884780	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccctggaattggccctcctCcagggcctgctgggggagaa	6	7	15	13	0	0	1	0	0	0	1	2	3	2	2	5	5	1	1	5	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:24884780C>T	uc001wpf.3	+	9	4143	c.3825C>T	c.(3823-3825)CTC>CTT	p.L1275L		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1275					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						TGGCCCTCCTCCAGGGCCTGC	0.632													23	74					0	0	0	0	T	24884780	T	T	24884780	2	4	276	1	0	0	0	0	0	0	0	1	10850	842	30	2		2	NYNRIN	14	24884780	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	237466	24884780	82464760	1380	51269											
KHNYN	23351	broad.mit.edu	37	chr14	24901080	24901080	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctagtgggcaggggccaggaGcactggcttcttgggagggg	6	7	20	8	0	1	0	0	0	1	0	1	2	1	2	1	8	1	3	1	8	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:24901080G>A	uc001wph.3	+	3	815	c.613G>A	c.(613-615)GCA>ACA	p.A205T	KHNYN_uc010tpc.1_Missense_Mutation_p.A246T|KHNYN_uc010alw.2_Missense_Mutation_p.A205T|CBLN3_uc001wpg.3_5'Flank	NM_015299	NP_056114	O15037	KHNYN_HUMAN	hypothetical protein LOC23351	205										ovary(2)|liver(1)	3						GGGGCCAGGAGCACTGGCTTC	0.652											OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	105					0	0	0	0	A	24901080	A	A	24901080	3	1	276	1	0	0	0	0	1	0	0	0	8189	971	34	4	619	4	KHNYN	14	24901080	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	16300	24901080	82448460	1381	51270											
G2E3	55632	broad.mit.edu	37	chr14	31071301	31071301	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcatcacctaaattacccaGacagtcacctggatcccaga	13	8	6	14	0	3	2	3	0	0	2	4	3	4	3	4	1	1	0	4	1	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:31071301G>A	uc001wqk.2	+	10	1128	c.974G>A	c.(973-975)AGA>AAA	p.R325K	G2E3_uc010tpe.1_Missense_Mutation_p.R240K|G2E3_uc010tpf.1_Missense_Mutation_p.R279K	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	325					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						AAATTACCCAGACAGTCACCT	0.348													26	44					0	0	0	0	A	31071301	A	A	31071301	3	1	276	1	0	0	0	0	1	0	0	0	6174	942	33	2	1008	2	G2E3	14	31071301	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6170221	31071301	76278239	1382	51271											
SCFD1	23256	broad.mit.edu	37	chr14	31185183	31185183	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atggagatgaagtcaaacccCgtgagtaccatataacatat	16	9	8	8	1	1	3	1	2	0	1	1	4	1	3	3	1	3	1	3	1	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:31185183C>T	uc001wqm.1	+	20	1707	c.1683C>T	c.(1681-1683)CCC>CCT	p.P561P	SCFD1_uc001wqn.1_Silent_p.P494P|SCFD1_uc010tpg.1_Silent_p.P502P|SCFD1_uc010tph.1_Silent_p.P376P|SCFD1_uc010amf.1_Silent_p.P376P|SCFD1_uc010tpi.1_Silent_p.P469P|SCFD1_uc010amd.1_3'UTR|SCFD1_uc010ame.1_Silent_p.P494P	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	561					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		AGTCAAACCCCGTGAGTACCA	0.328													9	86					0	0	0	0	T	31185183	T	T	31185183	2	4	276	1	0	0	0	0	0	0	0	1	13954	666	23	1		1	SCFD1	14	31185183	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	113882	31185183	76164357	1383	51272											
COCH	1690	broad.mit.edu	37	chr14	31346827	31346827	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcttggacatcaggaaagaGaaagcagatgtcctctgccc	12	7	12	10	0	2	2	1	0	1	2	3	5	3	4	2	3	2	2	2	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:31346827G>A	uc001wqr.2	+	4	212	c.132G>A	c.(130-132)GAG>GAA	p.E44E	COCH_uc001wqp.2_Silent_p.E44E|COCH_uc001wqq.3_Silent_p.E44E|uc001wqs.2_Intron|COCH_uc001wqt.1_5'Flank	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	44	LCCL.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TCAGGAAAGAGAAAGCAGATG	0.463													10	77					0	0	0	0	A	31346827	A	A	31346827	2	1	276	1	0	0	0	0	0	0	0	1	3671	933	33	2		2	COCH	14	31346827	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	161644	31346827	76002713	1384	51273											
HECTD1	25831	broad.mit.edu	37	chr14	31574596	31574596	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctttaaaattacctctaaaGgcttccatttgtttctgaat	11	17	4	9	0	2	1	0	1	2	0	3	1	3	1	3	1	1	2	3	1	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:31574596G>A	uc001wrc.1	-	40	7881	c.7392C>T	c.(7390-7392)GCC>GCT	p.A2464A	HECTD1_uc001wra.1_Silent_p.A590A|HECTD1_uc001wrb.1_Silent_p.A590A	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	2464	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TACCTCTAAAGGCTTCCATTT	0.318													68	147					0	0	0	0	A	31574596	A	A	31574596	2	1	276	1	0	0	0	0	0	0	0	1	7078	987	35	4		4	HECTD1	14	31574596	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	227769	31574596	75774944	1385	51274											
AKAP6	9472	broad.mit.edu	37	chr14	33293542	33293542	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agccttgtttctctagtgctCctccaaatgaatctgcagtt	8	15	7	11	0	2	1	0	1	2	0	5	1	4	1	3	0	3	4	3	0	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:33293542C>T	uc001wrq.2	+	13	6693	c.6523C>T	c.(6523-6525)CCT>TCT	p.P2175S		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2175					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CTCTAGTGCTCCTCCAAATGA	0.468													7	36					0	0	0	0	T	33293542	T	T	33293542	3	4	276	1	0	0	0	0	1	0	0	0	455	855	30	2	6569	2	AKAP6	14	33293542	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1718946	33293542	74055998	1386	51275											
KIAA0391	9692	broad.mit.edu	37	chr14	35595980	35595980	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaaggacaattcaccacagtCcgaaaaaggtgaagaccaat	19	5	8	9	1	1	2	1	1	0	1	2	4	2	3	3	2	0	0	3	2	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:35595980C>T	uc001wsy.1	+	3	1386	c.1026C>T	c.(1024-1026)GTC>GTT	p.V342V	KIAA0391_uc010tps.1_Silent_p.V247V|KIAA0391_uc001wsz.1_Intron|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Intron|KIAA0391_uc001wtc.1_5'UTR	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	342					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		TCACCACAGTCCGAAAAAGGT	0.318													4	27					0	0	0	0	T	35595980	T	T	35595980	2	4	276	1	0	0	0	0	0	0	0	1	8211	842	30	2		2	KIAA0391	14	35595980	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2302438	35595980	71753560	1387	51276											
SLC25A21	89874	broad.mit.edu	37	chr14	37194875	37194875	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagatcccaatccagcaatgGcgaatgtctagaaaaattaa	17	8	7	9	1	1	2	0	0	1	2	3	3	3	2	2	1	1	1	2	1	7	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:37194875G>A	uc001wtz.1	-	6	648	c.338C>T	c.(337-339)GCC>GTC	p.A113V		NM_030631	NP_085134	Q9BQT8	ODC_HUMAN	solute carrier family 25 (mitochondrial	113	Solcar 2.|Helical; Name=3; (Potential).				lysine catabolic process	integral to membrane|mitochondrial inner membrane	alpha-ketoglutarate transmembrane transporter activity|binding			skin(1)	1	Esophageal squamous(585;0.164)|Breast(36;0.179)|Hepatocellular(127;0.213)		Lung(8;2.16e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.0112)|all cancers(34;0.0274)|LUSC - Lung squamous cell carcinoma(13;0.149)	GBM - Glioblastoma multiforme(112;0.00204)		TCCAGCAATGGCGAATGTCTA	0.368													7	35					0	0	0	0	A	37194875	A	A	37194875	3	1	276	1	0	0	0	0	1	0	0	0	14548	1203	42	4	586	4	SLC25A21	14	37194875	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1598895	37194875	70154665	1388	51277											
MIA2	117153	broad.mit.edu	37	chr14	39717158	39717158	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataccatatttgaaaaagttCttgtataattttgacaaccc	15	15	4	7	0	1	2	0	2	1	0	1	2	1	2	2	0	2	2	2	0	7	9			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:39717158C>T	uc001wux.2	+	4	1574	c.1380C>T	c.(1378-1380)TTC>TTT	p.F460F	MIA2_uc010amy.1_Silent_p.F391F	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	460						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		TGAAAAAGTTCTTGTATAATT	0.308													24	90					0	0	0	0	T	39717158	T	T	39717158	2	4	276	1	0	0	0	0	0	0	0	1	9617	912	32	2		2	MIA2	14	39717158	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2522283	39717158	67632382	1389	51278											
RPL10L	140801	broad.mit.edu	37	chr14	47120888	47120888	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcggcagaaacgagattttgGgtacggcttgttcttacaat	10	13	11	7	3	1	2	0	0	1	2	2	3	1	2	0	3	3	4	0	3	4	6	rs146301674		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:47120888G>A	uc001wwg.2	-	1	141	c.52C>T	c.(52-54)CCA>TCA	p.P18S		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	18					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						CGAGATTTTGGGTACGGCTTG	0.547													42	87					0	0	0	0	A	47120888	A	A	47120888	3	1	276	1	0	0	0	0	1	0	0	0	13621	1232	43	4	596	4	RPL10L	14	47120888	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	7403730	47120888	60228652	1390	51279											
C14orf101	54916	broad.mit.edu	37	chr14	57099810	57099810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtcttgtgacaaattagttCctttggagattgtattcaac	10	16	9	6	0	2	2	1	1	1	1	3	3	3	2	1	2	1	2	1	2	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:57099810C>T	uc001xcm.2	+	13	1767	c.1645C>T	c.(1645-1647)CCT>TCT	p.P549S	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_Missense_Mutation_p.P82S|C14orf101_uc001xco.2_Missense_Mutation_p.P82S	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	549						integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		CAAATTAGTTCCTTTGGAGAT	0.378													31	51					0	0	0	0	T	57099810	T	T	57099810	3	4	276	1	0	0	0	0	1	0	0	0	1740	855	30	2	1695	2	C14orf101	14	57099810	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	9978922	57099810	50249730	1391	51280											
C14orf37	145407	broad.mit.edu	37	chr14	58605578	58605578	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaatgggctgaaagttagTgcttgtaaggagttcctcct	10	13	11	7	0	0	1	0	1	0	0	2	2	2	2	2	2	2	5	2	2	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:58605578T>G	uc001xdc.2	-	2	610	c.499A>C	c.(499-501)ACT>CCT	p.T167P	C14orf37_uc010tro.1_Missense_Mutation_p.T205P|C14orf37_uc001xdd.2_Missense_Mutation_p.T167P|C14orf37_uc001xde.2_Missense_Mutation_p.T167P	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	167	Extracellular (Potential).					integral to membrane	binding				0						TGAAAGTTAGTGCTTGTAAGG	0.408													4	38					0	0	0	0	G	58605578	G	G	58605578	3	3	276	1	0	0	0	0	1	0	0	0	1777	1696	59	5	1853	5	C14orf37	14	58605578	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1505768	58605578	48743962	1392	51281											
ARID4A	5926	broad.mit.edu	37	chr14	58814436	58814436	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgttcatcaccatgaacCaaaagtaaaagaggaaaaaa	22	6	6	7	0	2	2	2	1	0	1	2	3	2	3	2	1	2	2	2	1	9	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:58814436C>T	uc001xdp.2	+	15	1498	c.1244C>T	c.(1243-1245)CCA>CTA	p.P415L	ARID4A_uc001xdo.2_Missense_Mutation_p.P415L|ARID4A_uc001xdq.2_Missense_Mutation_p.P415L|ARID4A_uc010apg.1_Missense_Mutation_p.P93L	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	415					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						CACCATGAACCAAAAGTAAAA	0.348													32	75					0	0	0	0	T	58814436	T	T	58814436	3	4	276	1	0	0	0	0	1	0	0	0	919	594	21	4	1298	4	ARID4A	14	58814436	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	208858	58814436	48535104	1393	51282											
DACT1	51339	broad.mit.edu	37	chr14	59113414	59113414	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttcctacgaagaggccctGaggagggcccggcgcggtcg	7	6	16	12	5	0	2	0	1	0	1	2	4	1	3	3	5	1	0	3	5	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:59113414G>A	uc001xdw.2	+	4	2237	c.2073G>A	c.(2071-2073)CTG>CTA	p.L691L	DACT1_uc010trv.1_Silent_p.L410L|DACT1_uc001xdx.2_Silent_p.L654L|DACT1_uc010trw.1_Silent_p.L410L	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	691					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						AAGAGGCCCTGAGGAGGGCCC	0.677													9	32					0	0	0	0	A	59113414	A	A	59113414	2	1	276	1	0	0	0	0	0	0	0	1	4239	1277	45	2		2	DACT1	14	59113414	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	298978	59113414	48236126	1394	51283											
C14orf135	64430	broad.mit.edu	37	chr14	60591858	60591858	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaatagacaatatggctcCtagtcctggtcatatattga	12	13	9	7	0	1	2	1	1	0	1	3	3	3	3	2	3	0	1	2	3	7	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:60591858C>T	uc001xer.3	+	8	2789	c.2267C>T	c.(2266-2268)CCT>CTT	p.P756L	C14orf135_uc001xeq.2_Missense_Mutation_p.P756L|C14orf135_uc010apm.2_RNA	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	990						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		AATATGGCTCCTAGTCCTGGT	0.378													12	25					0	0	0	0	T	60591858	T	T	60591858	3	4	276	1	0	0	0	0	1	0	0	0	1751	681	24	4	2293	4	C14orf135	14	60591858	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1478444	60591858	46757682	1395	51284											
PRKCH	5583	broad.mit.edu	37	chr14	61952223	61952223	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgtgtttgtatccaggatCgtctgttttttgtgatggag	5	19	12	5	1	1	1	0	1	1	0	3	3	2	3	1	2	0	3	1	2	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:61952223C>T	uc001xfn.2	+	10	1587	c.1282C>T	c.(1282-1284)CGT>TGT	p.R428C	PRKCH_uc010tsa.1_Missense_Mutation_p.R267C|PRKCH_uc010tsb.1_5'UTR	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	428	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		TATCCAGGATCGTCTGTTTTT	0.473													127	272					0	0	0	0	T	61952223	T	T	61952223	3	4	276	1	0	0	0	0	1	0	0	0	12575	884	31	1	1320	1	PRKCH	14	61952223	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1360365	61952223	45397317	1396	51285											
SYT16	83851	broad.mit.edu	37	chr14	62536443	62536443	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttcagtgacatctgagaaaGgaaagcagacaggattggag	15	7	14	5	0	2	3	1	2	1	2	2	7	2	6	0	3	1	2	0	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:62536443G>A	uc001xfu.1	+	2	843	c.646G>A	c.(646-648)GGA>AGA	p.G216R	SYT16_uc010tsd.1_Missense_Mutation_p.G216R	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	216										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		ATCTGAGAAAGGAAAGCAGAC	0.483													51	116					0	0	0	0	A	62536443	A	A	62536443	3	1	276	1	0	0	0	0	1	0	0	0	15538	1001	35	4	652	4	SYT16	14	62536443	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	584220	62536443	44813097	1397	51286											
PLEKHG3	26030	broad.mit.edu	37	chr14	65208865	65208865	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccactgaggggcgcagccCggcccacctggcccgggagc	5	3	15	18	3	0	1	0	1	0	0	1	2	1	2	5	5	2	1	5	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:65208865C>T	uc001xho.1	+	16	2899	c.2630C>T	c.(2629-2631)CCG>CTG	p.P877L	PLEKHG3_uc001xhn.1_Missense_Mutation_p.P821L|PLEKHG3_uc001xhp.2_Missense_Mutation_p.P998L|PLEKHG3_uc010aqh.1_Missense_Mutation_p.P419L|PLEKHG3_uc001xhq.1_Missense_Mutation_p.P382L	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	877					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		GGGCGCAGCCCGGCCCACCTG	0.672													12	40					0	0	0	0	T	65208865	T	T	65208865	3	4	276	1	0	0	0	0	1	0	0	0	12125	652	23	1	2512	1	PLEKHG3	14	65208865	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2672422	65208865	42140675	1398	51287											
FNTB	2342	broad.mit.edu	37	chr14	65453806	65453806	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggtggaaacagtcacgtcCatagaacaggtgaggtggca	12	7	14	8	2	1	2	1	1	0	1	3	3	2	3	1	5	2	1	1	5	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:65453806C>T	uc001xia.2	+	1	300	c.135C>T	c.(133-135)TCC>TCT	p.S45S	FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|uc001xib.2_5'Flank	NM_002028	NP_002019	P49356	FNTB_HUMAN	farnesyltransferase, CAAX box, beta	45					protein farnesylation	microtubule associated complex	protein binding|protein farnesyltransferase activity			ovary(1)	1				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CAGTCACGTCCATAGAACAGG	0.667													16	31					0	0	0	0	T	65453806	T	T	65453806	2	4	276	1	0	0	0	0	0	0	0	1	6010	581	21	4		4	FNTB	14	65453806	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	244941	65453806	41895734	1399	51288											
PLEK2	26499	broad.mit.edu	37	chr14	67859925	67859925	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggggcttgaacggattccGgtgttgctatcgtgcatctt	5	15	13	8	3	1	1	0	1	1	0	3	2	2	2	1	4	3	4	1	4	2	6	rs149134361		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:67859925G>A	uc001xjh.1	-	4	475	c.423C>T	c.(421-423)ACC>ACT	p.T141T		NM_016445	NP_057529	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	141	DEP.				actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				ovary(1)|pancreas(1)	2				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		AACGGATTCCGGTGTTGCTAT	0.582													41	213					0	0	0	0	A	67859925	A	A	67859925	2	1	276	1	0	0	0	0	0	0	0	1	12109	1103	39	1		1	PLEK2	14	67859925	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2406119	67859925	39489615	1400	51289											
DCAF5	8816	broad.mit.edu	37	chr14	69558501	69558501	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atggatgtcatagagcacagGgggcaggcgtcgcctcaggg	9	6	17	9	2	2	1	2	0	0	1	3	2	2	2	1	5	1	2	1	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:69558501G>A	uc001xkp.2	-	6	988	c.769C>T	c.(769-771)CCT>TCT	p.P257S	DCAF5_uc001xkq.2_Missense_Mutation_p.P256S|DCAF5_uc001xkr.3_Missense_Mutation_p.P257S	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	257						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2						TAGAGCACAGGGGGCAGGCGT	0.542													20	126					0	0	0	0	A	69558501	A	A	69558501	3	1	276	1	0	0	0	0	1	0	0	0	4290	1232	43	4	2075	4	DCAF5	14	69558501	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1698576	69558501	37791039	1401	51290											
PCNX	22990	broad.mit.edu	37	chr14	71444535	71444535	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgaagaagccaataaaaatcCccatgcaaatgaatttactt	18	10	5	8	0	0	3	0	2	0	1	1	3	1	3	3	0	3	1	3	0	9	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:71444535C>T	uc001xmo.2	+	6	1927	c.1481C>T	c.(1480-1482)CCC>CTC	p.P494L	PCNX_uc001xmn.3_Missense_Mutation_p.P494L|PCNX_uc010are.1_Missense_Mutation_p.P494L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	494						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AATAAAAATCCCCATGCAAAT	0.493													10	27					0	0	0	0	T	71444535	T	T	71444535	3	4	276	1	0	0	0	0	1	0	0	0	11645	623	22	4	1503	4	PCNX	14	71444535	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1886034	71444535	35905005	1402	51291											
ZFYVE1	53349	broad.mit.edu	37	chr14	73490962	73490962	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cacctcactattgccctctgCctaacacctggtaaatgccc	9	10	5	17	0	2	0	1	0	1	0	2	0	2	0	5	1	4	1	5	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:73490962C>T	uc001xnm.2	-	2	895	c.255G>A	c.(253-255)AGG>AGA	p.R85R	ZFYVE1_uc010arj.2_Silent_p.R85R	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	85						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		TTGCCCTCTGCCTAACACCTG	0.517													44	210					0	0	0	0	T	73490962	T	T	73490962	2	4	276	1	0	0	0	0	0	0	0	1	17730	738	26	4		4	ZFYVE1	14	73490962	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2046427	73490962	33858578	1403	51292											
FAM161B	145483	broad.mit.edu	37	chr14	74411450	74411450	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtcatgcggaatggccgaggGacagtaatggatgatgccca	11	7	15	8	2	1	1	1	1	0	0	1	5	1	4	2	4	2	1	2	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:74411450G>A	uc001xpd.1	-	3	619	c.513C>T	c.(511-513)GTC>GTT	p.V171V		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						ATGGCCGAGGGACAGTAATGG	0.662													4	33					0	0	0	0	A	74411450	A	A	74411450	2	1	276	1	0	0	0	0	0	0	0	1	5501	1161	41	2		2	FAM161B	14	74411450	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	920488	74411450	32938090	1404	51293											
TMEM90A	646658	broad.mit.edu	37	chr14	74874630	74874630	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagagagtaagtcccaggtgGtccctgggaggcagcgtgag	10	6	17	8	1	0	2	0	1	0	1	2	4	2	3	2	4	1	2	2	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:74874630G>A	uc001xpx.2	-	3	728	c.480C>T	c.(478-480)GAC>GAT	p.D160D		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	160					response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		GTCCCAGGTGGTCCCTGGGAG	0.577													6	43					0	0	0	0	A	74874630	A	A	74874630	2	1	276	1	0	0	0	0	0	0	0	1	16284	1252	44	4		4	TMEM90A	14	74874630	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	463180	74874630	32474910	1405	51294											
ANGEL1	23357	broad.mit.edu	37	chr14	77275791	77275791	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaagtgccaggctgctctggGctagtcctttatctataagg	8	12	12	9	0	2	0	0	0	2	0	3	1	3	0	2	3	2	3	2	3	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:77275791G>T	uc001xsv.2	-	2	373	c.260C>A	c.(259-261)GCC>GAC	p.A87D	ANGEL1_uc010tvf.1_Missense_Mutation_p.A87D	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	87										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		GCTGCTCTGGGCTAGTCCTTT	0.567													9	53					0.00621372	0.00627059	1	0	T	77275791	T	T	77275791	3	4	276	1	0	0	0	0	1	0	0	0	608	1203	42	4	1788	4	ANGEL1	14	77275791	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2401161	77275791	30073749	1406	51295											
POMT2	29954	broad.mit.edu	37	chr14	77746178	77746178	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctgacctgcaacctccgCtggcagccgtgcccctctct	5	8	9	19	2	1	1	0	1	1	0	3	2	2	1	7	1	4	3	7	1	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:77746178C>T	uc001xti.2	-	18	2080	c.1879G>A	c.(1879-1881)GCG>ACG	p.A627T	POMT2_uc001xth.1_Missense_Mutation_p.A325T	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	627					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		GCAACCTCCGCTGGCAGCCGT	0.657													5	26					0	0	0	0	T	77746178	T	T	77746178	3	4	276	1	0	0	0	0	1	0	0	0	12301	797	28	4	389	4	POMT2	14	77746178	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	470387	77746178	29603362	1407	51296											
C14orf148	122945	broad.mit.edu	37	chr14	77872358	77872358	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cacagtcttcaaagtgcacgGagagaaagagttcactcaga	15	7	10	9	1	4	3	3	0	1	3	4	5	4	4	0	1	1	2	0	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:77872358G>A	uc001xtr.2	-	5	950	c.803C>T	c.(802-804)TCC>TTC	p.S268F		NM_001113475	NP_001106946	Q6NXP6	CN148_HUMAN	hypothetical protein LOC122945 isoform 1	268					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		AAAGTGCACGGAGAGAAAGAG	0.468													14	55					0	0	0	0	A	77872358	A	A	77872358	3	1	276	1	0	0	0	0	1	0	0	0	1757	1174	41	2	284	2	C14orf148	14	77872358	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	126180	77872358	29477182	1408	51297											
C14orf148	122945	broad.mit.edu	37	chr14	77889183	77889183	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagatacgatcttcctctGgaaccccatactcaaactgc	11	9	6	15	1	3	1	1	0	2	1	4	3	4	2	4	1	5	0	4	1	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:77889183G>A	uc001xtr.2	-	1	197	c.50C>T	c.(49-51)CCA>CTA	p.P17L	C14orf148_uc010tvi.1_Missense_Mutation_p.P17L	NM_001113475	NP_001106946	Q6NXP6	CN148_HUMAN	hypothetical protein LOC122945 isoform 1	17					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		ATCTTCCTCTGGAACCCCATA	0.478													39	206					0	0	0	0	A	77889183	A	A	77889183	3	1	276	1	0	0	0	0	1	0	0	0	1757	1348	47	4	1122	4	C14orf148	14	77889183	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	16825	77889183	29460357	1409	51298											
ISM2	145501	broad.mit.edu	37	chr14	77950775	77950775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcctgggaggcgtggcattcCctggggtcagggctgctggc	3	9	18	11	1	1	0	1	0	0	0	3	1	3	1	2	7	1	3	2	7	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:77950775C>T	uc001xtz.2	-	3	592	c.518G>A	c.(517-519)GGG>GAG	p.G173E	ISM2_uc001xua.2_Missense_Mutation_p.G173E|ISM2_uc001xty.2_Missense_Mutation_p.G85E|ISM2_uc010tvl.1_Intron	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	173						extracellular region				skin(1)	1						CGTGGCATTCCCTGGGGTCAG	0.602													14	102					0	0	0	0	T	77950775	T	T	77950775	3	4	276	1	0	0	0	0	1	0	0	0	7900	623	22	4	1217	4	ISM2	14	77950775	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	61592	77950775	29398765	1410	51299											
PTPN21	11099	broad.mit.edu	37	chr14	88938664	88938665	+	Missense_Mutation	DNP	GG	AA	AA																															ccactctcacatcatcataaGgaagaacatcttggaatcga																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:88938664_88938665GG>AA	uc001xwv.3	-	15	3125_3126	c.2794_2795CC>TT	c.(2794-2796)CCT>TTT	p.P932F	PTPN21_uc010twc.1_Missense_Mutation_p.P728F	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	932	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						ATCATCATAAGGAAGAACATCT	0.411													8	64					0	0	0	0	AA	88938665	AA	AA	88938664	3	1	276	1	0	0	0	0	1	0	0	0	12851	1000	35	4	749	4	PTPN21	14	88938664	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	10987889	88938664	18410876	1411	51300											
FOXN3	1112	broad.mit.edu	37	chr14	89878802	89878802	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctttctggcttcttactggGaggcatgactggacccattt	6	14	11	10	0	2	1	0	1	2	0	2	3	2	3	1	4	1	3	1	4	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:89878802G>A	uc001xxo.3	-	2	156	c.19C>T	c.(19-21)CCC>TCC	p.P7S	FOXN3_uc001xxn.3_Missense_Mutation_p.P7S|FOXN3_uc010atk.2_Missense_Mutation_p.P7S|FOXN3_uc001xxp.2_Missense_Mutation_p.P7S	NM_001085471	NP_001078940	O00409	FOXN3_HUMAN	checkpoint suppressor 1 isoform 1	7					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(2)|ovary(1)	3						TTCTTACTGGGAGGCATGACT	0.512													11	65					0	0	0	0	A	89878802	A	A	89878802	3	1	276	1	0	0	0	0	1	0	0	0	6055	1174	41	2	1477	2	FOXN3	14	89878802	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	940138	89878802	17470738	1412	51301											
KCNK13	56659	broad.mit.edu	37	chr14	90650550	90650550	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccatcttgttcttcaacCtcttcctggagcgcctgatc	6	13	7	15	1	4	1	1	1	3	0	6	2	5	2	4	1	2	2	4	1	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:90650550C>T	uc001xye.1	+	2	872	c.430C>T	c.(430-432)CTC>TTC	p.L144F		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	144	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				GTTCTTCAACCTCTTCCTGGA	0.557													20	110					0	0	0	0	T	90650550	T	T	90650550	3	4	276	1	0	0	0	0	1	0	0	0	8100	681	24	4	436	4	KCNK13	14	90650550	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	771748	90650550	16698990	1413	51302											
CCDC88C	440193	broad.mit.edu	37	chr14	91770131	91770132	+	Missense_Mutation	DNP	GG	AA	AA																															cggatgagggcctcgtactcGgccgattgccgctcgtgcag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:91770131_91770132GG>AA	uc010aty.2	-	20	3647_3648	c.3548_3549CC>TT	c.(3547-3549)GCC>GTT	p.A1183V		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1183	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				CCTCGTACTCGGCCGATTGCCG	0.639													13	16					0	0	0	0	AA	91770132	AA	AA	91770131	3	1	276	1	0	0	0	0	1	0	0	0	2878	1103	39	1	2581	1	CCDC88C	14	91770131	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	1119581	91770131	15579409	1414	51303											
CPSF2	53981	broad.mit.edu	37	chr14	92600677	92600677	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaatacagcagctaaaattCtctcagattgtgaatttgaa	17	12	6	6	0	2	3	1	2	1	1	3	3	2	3	0	0	3	2	0	0	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:92600677C>T	uc001yah.1	+	5	630	c.393C>T	c.(391-393)TTC>TTT	p.F131F		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	131					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		AGCTAAAATTCTCTCAGATTG	0.333													6	35					0	0	0	0	T	92600677	T	T	92600677	2	4	276	1	0	0	0	0	0	0	0	1	3840	912	32	2		2	CPSF2	14	92600677	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	830546	92600677	14748863	1415	51304											
RIN3	79890	broad.mit.edu	37	chr14	93118295	93118295	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcccagccccctgtgctcCctgctcttgcccccgcccct	2	8	7	24	1	1	0	0	0	1	0	2	0	2	0	8	0	5	2	8	0	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:93118295C>T	uc001yap.2	+	6	1053	c.901C>T	c.(901-903)CCT>TCT	p.P301S	RIN3_uc010auk.2_5'UTR|RIN3_uc001yaq.2_Missense_Mutation_p.P226S|RIN3_uc001yar.1_5'UTR|RIN3_uc001yas.1_5'UTR	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	301	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				ccctgtgctccctgctcttgc	0.254													5	17					0	0	0	0	T	93118295	T	T	93118295	3	4	276	1	0	0	0	0	1	0	0	0	13438	623	22	4	923	4	RIN3	14	93118295	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	517618	93118295	14231245	1416	51305											
ITPK1	3705	broad.mit.edu	37	chr14	93483065	93483065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggactggctatcattctggtCggcttcaaggatgacgtcag	8	11	13	9	2	4	1	3	1	1	0	5	3	4	3	0	5	0	2	0	5	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:93483065C>T	uc001ybg.2	-	4	491	c.202G>A	c.(202-204)GAC>AAC	p.D68N	ITPK1_uc001ybe.2_Missense_Mutation_p.D68N|ITPK1_uc001ybf.2_5'UTR|ITPK1_uc001ybh.2_Missense_Mutation_p.D68N	NM_014216	NP_055031	Q13572	ITPK1_HUMAN	inositol 1,3,4-triphosphate 5/6 kinase isoform	68					blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding				0		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		TCATTCTGGTCGGCTTCAAGG	0.597													9	61					0	0	0	0	T	93483065	T	T	93483065	3	4	276	1	0	0	0	0	1	0	0	0	7955	884	31	1	1122	1	ITPK1	14	93483065	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	364770	93483065	13866475	1417	51306											
KIAA1409	57578	broad.mit.edu	37	chr14	94004455	94004455	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcaaatcatcacagtaatGaagtgggggccgctgcggag	12	7	13	9	2	3	1	3	1	0	0	3	2	3	2	1	3	1	2	1	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:94004455G>A	uc001ybv.1	+	9	795	c.712G>A	c.(712-714)GAA>AAA	p.E238K	KIAA1409_uc001ybs.1_Missense_Mutation_p.E238K|KIAA1409_uc001ybu.1_Missense_Mutation_p.E176K	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	415						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TCACAGTAATGAAGTGGGGGC	0.592													18	49					0	0	0	0	A	94004455	A	A	94004455	3	1	276	1	0	0	0	0	1	0	0	0	8269	1291	45	2	746	2	KIAA1409	14	94004455	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	521390	94004455	13345085	1418	51307											
KIAA1409	57578	broad.mit.edu	37	chr14	94041487	94041487	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttaattcagtcaaagagctGgcaaatcaaagaaaatcaag	19	8	8	6	0	4	2	4	0	0	2	4	2	4	2	0	1	1	3	0	1	7	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:94041487G>A	uc001ybv.1	+	14	1706	c.1623G>A	c.(1621-1623)CTG>CTA	p.L541L	KIAA1409_uc001ybs.1_Silent_p.L541L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	718						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TCAAAGAGCTGGCAAATCAAA	0.368													23	30					0	0	0	0	A	94041487	A	A	94041487	2	1	276	1	0	0	0	0	0	0	0	1	8269	1335	47	4		4	KIAA1409	14	94041487	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	37032	94041487	13308053	1419	51308											
KIAA1409	57578	broad.mit.edu	37	chr14	94149038	94149038	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatgatagcctctgtacctGgagtaagtcctgaccaaatt	12	11	9	9	0	1	3	0	2	1	1	2	4	2	4	4	1	2	2	4	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:94149038G>A	uc001ybv.1	+	41	6552	c.6469G>A	c.(6469-6471)GGA>AGA	p.G2157R	KIAA1409_uc001ybs.1_Missense_Mutation_p.G2135R	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2312						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CTCTGTACCTGGAGTAAGTCC	0.269													14	39					0	0	0	0	A	94149038	A	A	94149038	3	1	276	1	0	0	0	0	1	0	0	0	8269	1349	47	4	6561	4	KIAA1409	14	94149038	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	107551	94149038	13200502	1420	51309											
PRIMA1	145270	broad.mit.edu	37	chr14	94245575	94245576	+	Missense_Mutation	DNP	GG	AA	AA																															gtgggggcggcgggggcagcGggggagggggccggcactgg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:94245575_94245576GG>AA	uc001ybw.1	-	3	217_218	c.175_176CC>TT	c.(175-177)CCG>TTG	p.P59L	PRIMA1_uc001ybx.1_RNA	NM_178013	NP_821092	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1 precursor	59	PRAD.|Extracellular (Potential).				neurotransmitter catabolic process	cell junction|integral to membrane|synapse				large_intestine(1)|skin(1)	2		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		cgggggcagcgggggagggggc	0.356													3	10					0	0	0	0	AA	94245576	AA	AA	94245575	3	1	276	1	0	0	0	0	1	0	0	0	12554	1116	39	1	297	1	PRIMA1	14	94245575	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	96537	94245575	13103965	1421	51310											
FAM181A	90050	broad.mit.edu	37	chr14	94395247	94395247	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgcctggggtctccttggtgGgccgcgtcaatgcctggagt	3	11	16	11	2	2	0	1	0	1	0	3	1	2	1	4	5	2	0	4	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:94395247G>A	uc001ybz.1	+	3	1109	c.802G>A	c.(802-804)GGC>AGC	p.G268S	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Missense_Mutation_p.G206S|FAM181A_uc001yca.1_Missense_Mutation_p.G206S	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	268											0						CTCCTTGGTGGGCCGCGTCAA	0.647													7	41					0	0	0	0	A	94395247	A	A	94395247	3	1	276	1	0	0	0	0	1	0	0	0	5536	1232	43	4	808	4	FAM181A	14	94395247	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	149672	94395247	12954293	1422	51311											
SERPINA4	5267	broad.mit.edu	37	chr14	95030212	95030212	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcacactctcaacctcccCggccatgggctggaaacacg	9	6	9	17	2	1	0	1	0	1	0	3	1	2	1	4	3	3	2	4	3	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:95030212C>T	uc001ydk.2	+	2	459	c.393C>T	c.(391-393)CCC>CCT	p.P131P	SERPINA4_uc010avd.2_Silent_p.P168P|SERPINA4_uc001ydl.2_Silent_p.P131P	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	131					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		TCAACCTCCCCGGCCATGGGC	0.582													13	84					0	0	0	0	T	95030212	T	T	95030212	2	4	276	1	0	0	0	0	0	0	0	1	14156	639	23	1		1	SERPINA4	14	95030212	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	634965	95030212	12319328	1423	51312											
SERPINA5	5104	broad.mit.edu	37	chr14	95053761	95053761	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagggggcctcccttcaccGccaccacccccgggagatga	7	5	11	18	2	2	2	2	1	0	1	3	3	3	2	7	3	0	0	7	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:95053761G>A	uc001ydm.2	+	3	272	c.62G>A	c.(61-63)CGC>CAC	p.R21H	SERPINA5_uc010ave.2_Missense_Mutation_p.R21H|SERPINA5_uc001ydn.1_Missense_Mutation_p.R21H	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	21					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	TCCCTTCACCGCCACCACCCC	0.587													20	111					0	0	0	0	A	95053761	A	A	95053761	3	1	276	1	0	0	0	0	1	0	0	0	14157	1087	38	1	64	1	SERPINA5	14	95053761	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	23549	95053761	12295779	1424	51313											
TCL1B	9623	broad.mit.edu	37	chr14	96152888	96152888	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcatctacgaagatgaggaGgggagaacctgggtgactgt	11	7	17	6	1	1	4	0	2	1	2	1	7	1	5	1	5	2	1	1	5	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:96152888G>A	uc001yez.2	+	1	126	c.84G>A	c.(82-84)GAG>GAA	p.E28E	TCL1B_uc001yew.2_Intron|TCL1B_uc001yex.2_Intron|TCL1B_uc010avj.2_Intron|TCL1B_uc001yfa.2_Silent_p.E28E	NM_004918	NP_004909	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B	28										ovary(1)	1		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		AAGATGAGGAGGGGAGAACCT	0.642													11	51					0	0	0	0	A	96152888	A	A	96152888	2	1	276	1	0	0	0	0	0	0	0	1	15771	991	35	4		4	TCL1B	14	96152888	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1099127	96152888	11196652	1425	51314											
BDKRB2	624	broad.mit.edu	37	chr14	96707406	96707406	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accttctgcacgatgcagatCatgcaggtgctgcggaacaa	11	8	11	11	2	2	1	1	0	1	1	2	3	2	2	1	2	6	4	1	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:96707406C>T	uc010avm.1	+	3	937	c.741C>T	c.(739-741)ATC>ATT	p.I247I	BDKRB2_uc010avl.1_3'UTR|BDKRB2_uc010twu.1_Silent_p.I220I|BDKRB2_uc001yfg.2_Silent_p.I247I	NM_000623	NP_000614	P30411	BKRB2_HUMAN	bradykinin receptor B2	247	Helical; Name=5; (Potential).				arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			ovary(3)|breast(1)|kidney(1)	5		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		CGATGCAGATCATGCAGGTGC	0.547													15	26					0	0	0	0	T	96707406	T	T	96707406	2	4	276	1	0	0	0	0	0	0	0	1	1395	816	29	2		2	BDKRB2	14	96707406	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	554518	96707406	10642134	1426	51315											
BDKRB1	623	broad.mit.edu	37	chr14	96730397	96730397	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatttgttcatcagcatcttCctggtggtggccatcagcca	8	13	9	11	0	4	0	3	0	1	0	5	0	5	0	3	3	2	2	3	3	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:96730397C>T	uc001yfh.2	+	3	586	c.378C>T	c.(376-378)TTC>TTT	p.F126F	BDKRB1_uc010avn.2_Silent_p.F126F	NM_000710	NP_000701	P46663	BKRB1_HUMAN	bradykinin receptor B1	126	Helical; Name=3; (Potential).				elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			ovary(3)	3		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		TCAGCATCTTCCTGGTGGTGG	0.622													25	88					0	0	0	0	T	96730397	T	T	96730397	2	4	276	1	0	0	0	0	0	0	0	1	1394	854	30	2		2	BDKRB1	14	96730397	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	22991	96730397	10619143	1427	51316											
AK7	122481	broad.mit.edu	37	chr14	96875277	96875277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgctccaaagccctggaccCcgtaagtagagcgttagctt	9	8	11	13	3	0	1	0	0	0	1	1	2	1	2	4	1	3	5	4	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:96875277C>T	uc001yfn.2	+	4	541	c.497C>T	c.(496-498)CCC>CTC	p.P166L		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	166	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GCCCTGGACCCCGTAAGTAGA	0.478													17	48					0	0	0	0	T	96875277	T	T	96875277	3	4	276	1	0	0	0	0	1	0	0	0	444	637	22	4	511	4	AK7	14	96875277	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	144880	96875277	10474263	1428	51317											
EML1	2009	broad.mit.edu	37	chr14	100402648	100402648	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acagttcctcgtgtcaaattCcggagactacgaaatcctct	11	11	7	12	3	2	1	1	0	1	1	6	3	5	1	3	1	1	1	3	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:100402648C>T	uc001ygs.2	+	19	2141	c.2072C>T	c.(2071-2073)TCC>TTC	p.S691F	EML1_uc010tww.1_Missense_Mutation_p.S679F|EML1_uc001ygr.2_Missense_Mutation_p.S710F	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	691	WD 9.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GTGTCAAATTCCGGAGACTAC	0.502													26	39					0	0	0	0	T	100402648	T	T	100402648	3	4	276	1	0	0	0	0	1	0	0	0	5120	855	30	2	2207	2	EML1	14	100402648	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3527371	100402648	6946892	1429	51318											
C14orf68	283600	broad.mit.edu	37	chr14	100795147	100795147	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcagcagcggcggctttcgGcctcggggccgttggctgtg	3	8	18	12	5	0	0	0	0	0	0	2	0	0	0	2	6	3	5	2	6	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:100795147G>A	uc001yhc.2	+	5	485	c.412G>A	c.(412-414)GCC>ACC	p.A138T	C14orf68_uc001yhd.2_5'UTR	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	138	Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				GCGGCTTTCGGCCTCGGGGCC	0.682													15	20					0	0	0	0	A	100795147	A	A	100795147	3	1	276	1	0	0	0	0	1	0	0	0	1784	1203	42	4	430	4	C14orf68	14	100795147	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	392499	100795147	6554393	1430	51319											
DLK1	8788	broad.mit.edu	37	chr14	101200538	101200538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatgagggccgggcctccCatgcctcctgcctgtgcccc	4	8	12	17	1	0	2	0	2	0	0	2	2	2	2	8	2	3	0	8	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:101200538C>T	uc001yhs.3	+	5	610	c.457C>T	c.(457-459)CAT>TAT	p.H153Y	DLK1_uc001yhu.3_Missense_Mutation_p.H153Y	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	153	Extracellular (Potential).|EGF-like 4.				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				CCGGGCCTCCCATGCCTCCTG	0.637													18	74					0	0	0	0	T	101200538	T	T	101200538	3	4	276	1	0	0	0	0	1	0	0	0	4586	594	21	4	475	4	DLK1	14	101200538	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	405391	101200538	6149002	1431	51320											
WDR20	91833	broad.mit.edu	37	chr14	102675278	102675278	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagtggagctgcacggtacGatgaaaagctactttggggg	10	9	15	7	2	1	1	1	1	0	0	1	3	1	2	0	4	5	4	0	4	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:102675278G>T	uc001ykz.2	+	3	820	c.771G>T	c.(769-771)ACG>ACT	p.T257T	WDR20_uc001yky.1_5'UTR|WDR20_uc001yla.2_Silent_p.T133T|WDR20_uc001ylb.2_Silent_p.T196T|WDR20_uc010txu.1_Silent_p.T288T|WDR20_uc001ylc.2_Intron|WDR20_uc001yld.2_Silent_p.T257T|WDR20_uc001yle.2_Silent_p.T196T|WDR20_uc001ylf.2_Silent_p.T269T	NM_144574	NP_653175	Q8TBZ3	WDR20_HUMAN	WD repeat domain 20 isoform 2	257	WD 2.										0						TGCACGGTACGATGAAAAGCT	0.557													34	39					2.47316e-13	2.54439e-13	1	0	T	102675278	T	T	102675278	2	4	276	1	0	0	0	0	0	0	0	1	17348	1045	37	3		3	WDR20	14	102675278	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1474740	102675278	4674262	1432	51321											
C14orf73	91828	broad.mit.edu	37	chr14	103566784	103566784	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggaagatacgggcctgttCcggcgaagctcctgctccct	8	8	12	13	3	0	1	0	0	0	1	3	3	3	2	4	3	3	3	4	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:103566784C>T	uc001ymk.2	+	1	304	c.228C>T	c.(226-228)TTC>TTT	p.F76F		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	76											0		Melanoma(154;0.155)	Epithelial(46;0.221)			CGGGCCTGTTCCGGCGAAGCT	0.677													3	22					0	0	0	0	T	103566784	T	T	103566784	2	4	276	1	0	0	0	0	0	0	0	1	1785	854	30	2		2	C14orf73	14	103566784	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	891506	103566784	3782756	1433	51322											
AHNAK2	113146	broad.mit.edu	37	chr14	105408933	105408933	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtcatgtccttgtcggctagGgacaggtcaccctccagccg	6	9	12	14	2	2	0	2	0	0	0	5	1	4	1	4	3	1	1	4	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:105408933G>A	uc010axc.1	-	7	12975	c.12855C>T	c.(12853-12855)TCC>TCT	p.S4285S	AHNAK2_uc001ypx.2_Silent_p.S4185S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4285						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGTCGGCTAGGGACAGGTCAC	0.612													128	257					0	0	0	0	A	105408933	A	A	105408933	2	1	276	1	0	0	0	0	0	0	0	1	415	1219	43	4		4	AHNAK2	14	105408933	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1842149	105408933	1940607	1434	51323											
AHNAK2	113146	broad.mit.edu	37	chr14	105414531	105414532	+	Missense_Mutation	DNP	GG	AA	AA																															gggcccttgacatctatctgGgggcccttgagatctacttt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:105414531_105414532GG>AA	uc010axc.1	-	7	7376_7377	c.7256_7257CC>TT	c.(7255-7257)CCC>CTT	p.P2419L	AHNAK2_uc001ypx.2_Missense_Mutation_p.P2319L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2419						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CATCTATCTGGGGGCCCTTGAG	0.639													61	272					0	0	0	0	AA	105414532	AA	AA	105414531	3	1	276	1	0	0	0	0	1	0	0	0	415	1219	43	4	10134	4	AHNAK2	14	105414531	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	5598	105414531	1935009	1435	51324											
AHNAK2	113146	broad.mit.edu	37	chr14	105417195	105417195	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccttgaggtccccctgcatGgaggggaggctcacgtcggc	5	7	16	13	2	1	1	1	1	0	0	3	3	2	3	3	6	1	2	3	6	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:105417195G>A	uc010axc.1	-	7	4713	c.4593C>T	c.(4591-4593)TCC>TCT	p.S1531S	AHNAK2_uc001ypx.2_Silent_p.S1431S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1531						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCCCTGCATGGAGGGGAGGC	0.642													19	197					0	0	0	0	A	105417195	A	A	105417195	2	1	276	1	0	0	0	0	0	0	0	1	415	1335	47	4		4	AHNAK2	14	105417195	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2664	105417195	1932345	1436	51325											
AHNAK2	113146	broad.mit.edu	37	chr14	105418185	105418185	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcttgaggtccccctgcatGgaggggagactcacgtcggc	6	8	15	12	2	2	2	1	1	1	1	4	4	3	3	2	5	1	1	2	5	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr14:105418185G>A	uc010axc.1	-	7	3723	c.3603C>T	c.(3601-3603)TCC>TCT	p.S1201S	AHNAK2_uc001ypx.2_Silent_p.S1101S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1201						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCCCTGCATGGAGGGGAGAC	0.642													9	191					0	0	0	0	A	105418185	A	A	105418185	2	1	276	1	0	0	0	0	0	0	0	1	415	1335	47	4		4	AHNAK2	14	105418185	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	990	105418185	1931355	1437	51326											
OR4M2	390538	broad.mit.edu	37	chr15	22368758	22368758	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgacctctcctatgtatttCctgttggctaatctggcctt	5	17	7	12	0	2	1	0	1	2	0	4	1	3	1	4	2	0	3	4	2	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:22368758C>T	uc010tzu.1	+	1	183	c.183C>T	c.(181-183)TTC>TTT	p.F61F	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTATGTATTTCCTGTTGGCTA	0.388													131	446					0	0	0	0	T	22368758	T	T	22368758	2	4	276	1	0	0	0	0	0	0	0	1	11130	854	30	2		2	OR4M2	15	22368758	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08		22368758	80162634	1438	51327											
MAGEL2	54551	broad.mit.edu	37	chr15	23889933	23889933	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caactacgggcagagagctcCctgggctttcagagagaccc	10	6	12	13	1	1	3	1	0	0	3	2	5	2	3	2	2	3	3	2	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:23889933C>T	uc001ywj.3	-	1	1243	c.1148G>A	c.(1147-1149)GGG>GAG	p.G383E		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		CAGAGAGCTCCCTGGGCTTTC	0.642													8	23					0	0	0	0	T	23889933	T	T	23889933	3	4	276	1	0	0	0	0	1	0	0	0	9242	623	22	4	796	4	MAGEL2	15	23889933	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1521175	23889933	78641459	1439	51328											
C15orf2	23742	broad.mit.edu	37	chr15	24922239	24922239	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccaacctgtgcagaccacaGactccctgcccctgaccact	9	6	6	20	0	0	3	0	1	0	2	1	3	1	3	7	0	3	1	7	0	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:24922239G>A	uc001ywo.2	+	1	1699	c.1225G>A	c.(1225-1227)GAC>AAC	p.D409N		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	409	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GCAGACCACAGACTCCCTGCC	0.542													11	65					0	0	0	0	A	24922239	A	A	24922239	3	1	276	1	0	0	0	0	1	0	0	0	1790	942	33	2	1227	2	C15orf2	15	24922239	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1032306	24922239	77609153	1440	51329			1	77		3	3	115	N	G_C_A	3.016662e-05
C15orf2	23742	broad.mit.edu	37	chr15	24922337	24922337	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggacccctcatcctgcctatCcctccactttccaccacacc	7	9	3	22	0	1	0	1	0	0	0	5	1	5	1	9	1	1	0	9	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:24922337C>T	uc001ywo.2	+	1	1797	c.1323C>T	c.(1321-1323)ATC>ATT	p.I441I		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	441	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TCCTGCCTATCCCTCCACTTT	0.532													18	75					0	0	0	0	T	24922337	T	T	24922337	2	4	276	1	0	0	0	0	0	0	0	1	1790	845	30	2		2	C15orf2	15	24922337	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	98	24922337	77609055	1441	51330			1	77		3	3	115	N	G_C_A	3.016662e-05
C15orf2	23742	broad.mit.edu	37	chr15	24922353	24922353	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatccctccactttccaccAcaccaaaaatggatgagaaa	15	8	4	14	0	0	1	0	1	0	1	3	3	3	2	5	1	0	0	5	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:24922353A>C	uc001ywo.2	+	1	1813	c.1339A>C	c.(1339-1341)ACA>CCA	p.T447P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	447	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		ACTTTCCACCACACCAAAAAT	0.502													15	95					0	0	0	0	C	24922353	C	C	24922353	3	2	276	1	0	0	0	0	1	0	0	0	1790	159	6	5	1341	5	C15orf2	15	24922353	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	16	24922353	77609039	1442	51331			1	77		3	3	115	N	G_C_A	3.016662e-05
ATP10A	57194	broad.mit.edu	37	chr15	25925040	25925041	+	Missense_Mutation	DNP	CC	TT	TT																															tctttgggagcactgcatctCctgggggacttcctggtcaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:25925040_25925041CC>TT	uc010ayu.2	-	21	4053_4054	c.3947_3948GG>AA	c.(3946-3948)AGG>AAA	p.R1316K		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1316	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CACTGCATCTCCTGGGGGACTT	0.54													13	101					0	0	0	0	TT	25925041	TT	TT	25925040	3	4	276	1	0	0	0	0	1	0	0	0	1118	854	30	2	555	2	ATP10A	15	25925040	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1002687	25925040	76606352	1443	51332											
ATP10A	57194	broad.mit.edu	37	chr15	25953190	25953191	+	Missense_Mutation	DNP	GG	AA	AA																															agctcctcgctgttttccagGgaggattcggcttctaggtg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:25953190_25953191GG>AA	uc010ayu.2	-	12	2613_2614	c.2507_2508CC>TT	c.(2506-2508)TCC>TTT	p.S836F		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	836	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TGTTTTCCAGGGAGGATTCGGC	0.525													20	47					0	0	0	0	AA	25953191	AA	AA	25953190	3	1	276	1	0	0	0	0	1	0	0	0	1118	1219	43	4	2031	4	ATP10A	15	25953190	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	28150	25953190	76578202	1444	51333											
GABRB3	2562	broad.mit.edu	37	chr15	26806283	26806283	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgggcaaggtctcccgaagGtgggtgttgatggttgtcat	6	13	16	6	1	2	1	1	1	1	0	3	2	2	1	1	5	0	3	1	5	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:26806283G>T	uc001zaz.2	-	8	1018	c.876C>A	c.(874-876)CAC>CAA	p.H292Q	GABRB3_uc010uae.1_Missense_Mutation_p.H207Q|GABRB3_uc001zba.2_Missense_Mutation_p.H292Q|GABRB3_uc001zbb.2_Missense_Mutation_p.H348Q	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	292	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCTCCCGAAGGTGGGTGTTGA	0.473													22	125					3.8784e-16	4.008e-16	1	0	T	26806283	T	T	26806283	3	4	276	1	0	0	0	0	1	0	0	0	6202	1252	44	4	553	4	GABRB3	15	26806283	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	853093	26806283	75725109	1445	51334											
OCA2	4948	broad.mit.edu	37	chr15	28116344	28116344	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcaatcagggacgacgccaGggctgagacccacaccacca	12	3	11	15	2	2	1	2	1	0	1	2	4	2	2	4	2	0	1	4	2	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:28116344G>A	uc001zbh.3	-	21	2310	c.2200C>T	c.(2200-2202)CTG>TTG	p.L734L	OCA2_uc010ayv.2_Silent_p.L710L	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	734	Helical; (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GACGACGCCAGGGCTGAGACC	0.572									Oculocutaneous_Albinism				16	65					0	0	0	0	A	28116344	A	A	28116344	2	1	276	1	0	0	0	0	0	0	0	1	10869	991	35	4		4	OCA2	15	28116344	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1310061	28116344	74415048	1446	51335											
HERC2	8924	broad.mit.edu	37	chr15	28358821	28358821	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acctgctcatcaaattcatgGagtctggaagaaaaagctca	15	9	8	9	0	5	1	4	0	1	1	5	3	5	3	1	2	2	2	1	2	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:28358821G>A	uc001zbj.2	-	91	14023	c.13917C>T	c.(13915-13917)CTC>CTT	p.L4639L	HERC2_uc001zbi.2_Silent_p.L328L	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4639	HECT.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CAAATTCATGGAGTCTGGAAG	0.537													7	32					0	0	0	0	A	28358821	A	A	28358821	2	1	276	1	0	0	0	0	0	0	0	1	7097	1161	41	2		2	HERC2	15	28358821	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	242477	28358821	74172571	1447	51336											
HERC2	8924	broad.mit.edu	37	chr15	28465693	28465693	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attttccttctttccccatcCtgtaggagttggtgctgcct	4	17	8	12	0	1	0	0	0	1	0	4	1	4	1	5	2	2	3	5	2	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:28465693C>T	uc001zbj.2	-	37	5856	c.5750G>A	c.(5749-5751)AGG>AAG	p.R1917K		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1917	MIB/HERC2.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTTCCCCATCCTGTAGGAGTT	0.597													64	110					0	0	0	0	T	28465693	T	T	28465693	3	4	276	1	0	0	0	0	1	0	0	0	7097	681	24	4	8982	4	HERC2	15	28465693	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	106872	28465693	74065699	1448	51337											
TJP1	7082	broad.mit.edu	37	chr15	30012590	30012590	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggctggcttaaatccagggGagtctattctatgaattggt	10	13	12	6	0	2	1	0	1	2	0	3	2	3	2	1	5	0	2	1	5	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:30012590G>A	uc001zcr.2	-	19	3210	c.2735C>T	c.(2734-2736)TCC>TTC	p.S912F	TJP1_uc010azl.2_Missense_Mutation_p.S900F|TJP1_uc001zcq.2_Missense_Mutation_p.S916F|TJP1_uc001zcs.2_Missense_Mutation_p.S912F	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	912					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		AAATCCAGGGGAGTCTATTCT	0.423													81	154					0	0	0	0	A	30012590	A	A	30012590	3	1	276	1	0	0	0	0	1	0	0	0	15995	1174	41	2	2551	2	TJP1	15	30012590	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1546897	30012590	72518802	1449	51338											
RYR3	6263	broad.mit.edu	37	chr15	34072526	34072526	+	Silent	SNP	C	T	T																															tcggtcttcaacaccaaaacCcccagggagaggtctagtaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:34072526C>T	uc001zhi.2	+	65	9322	c.9252C>T	c.(9250-9252)ACC>ACT	p.T3084T	RYR3_uc010bar.2_Silent_p.T3084T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3084					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACACCAAAACCCCCAGGGAGA	0.557													5	27					0	0	0	0	T	34072526	T	T	34072526	2	4	276	1	0	0	0	0	0	0	0	1	13835	610	22	4		4	RYR3	15	34072526	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4059936	34072526	68458866	1450	51339	115	2									
RYR3	6263	broad.mit.edu	37	chr15	34072528	34072528	+	Missense_Mutation	SNP	C	T	T																															ggtcttcaacaccaaaacccCcagggagaggtctagtaagt																								rs61996335	by1000genomes	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:34072528C>T	uc001zhi.2	+	65	9324	c.9254C>T	c.(9253-9255)CCC>CTC	p.P3085L	RYR3_uc010bar.2_Missense_Mutation_p.P3085L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3085					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACCAAAACCCCCAGGGAGAGG	0.562													4	28					0	0	0	0	T	34072528	T	T	34072528	3	4	276	1	0	0	0	0	1	0	0	0	13835	623	22	4	9512	4	RYR3	15	34072528	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2	34072528	68458864	1451	51340	115	2									
C15orf52	388115	broad.mit.edu	37	chr15	40627527	40627528	+	Missense_Mutation	DNP	CT	TC	TC																															tctgggagccctgctcctctCtgtggctcagggcaagtctg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:40627527_40627528CT>TC	uc001zlh.3	-	11	1452_1453	c.1436_1437AG>GA	c.(1435-1437)CAG>CGA	p.Q479R	C15orf52_uc010ucn.1_Missense_Mutation_p.Q269R	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	479										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CTGCTCCTCTCTGTGGCTCAGG	0.663													36	58					0	0	0	0	TC	40627528	TC	TC	40627527	3	4	276	1	0	0	0	0	1	0	0	0	1806	912	32	2	171	2	C15orf52	15	40627527	Missense_Mutation	DNP	CT	TCGA-D6-6516-01A-11D-1870-08	6554999	40627527	61903865	1452	51341											
DISP2	85455	broad.mit.edu	37	chr15	40659297	40659297	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttcggggctctgtgccagcgGacagcagccaaccagtgctg	7	7	14	13	2	1	0	0	0	1	0	2	1	1	1	3	3	6	3	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:40659297G>A	uc001zlk.1	+	8	1073	c.984G>A	c.(982-984)CGG>CGA	p.R328R		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	328					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TGTGCCAGCGGACAGCAGCCA	0.637													9	49					0	0	0	0	A	40659297	A	A	40659297	2	1	276	1	0	0	0	0	0	0	0	1	4562	1161	41	2		2	DISP2	15	40659297	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	31770	40659297	61872095	1453	51342											
C15orf23	90417	broad.mit.edu	37	chr15	40675113	40675113	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagagtgcgattcccaccCacttccgcctagctaccgga	9	8	8	16	3	0	1	0	0	0	1	2	3	2	2	5	1	4	1	5	1	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:40675113C>T	uc001zll.2	+	1	192	c.77C>T	c.(76-78)CCA>CTA	p.P26L	C15orf23_uc010ucp.1_Missense_Mutation_p.P26L|C15orf23_uc001zlo.2_Missense_Mutation_p.P26L|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	26						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		GATTCCCACCCACTTCCGCCT	0.567													30	41					0	0	0	0	T	40675113	T	T	40675113	3	4	276	1	0	0	0	0	1	0	0	0	1791	594	21	4	79	4	C15orf23	15	40675113	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	15816	40675113	61856279	1454	51343											
BAHD1	22893	broad.mit.edu	37	chr15	40751119	40751119	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtcgagcaggggatccccaCcgcagccgtgaccgtgatcg	8	5	14	14	5	0	2	0	2	0	0	3	4	1	3	5	2	2	2	5	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:40751119C>T	uc001zlu.2	+	2	527	c.456C>T	c.(454-456)CAC>CAT	p.H152H	BAHD1_uc001zlt.2_Silent_p.H152H|BAHD1_uc010bbp.1_Silent_p.H152H|BAHD1_uc001zlv.2_Silent_p.H152H	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	152					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		GGGATCCCCACCGCAGCCGTG	0.662													23	32					0	0	0	0	T	40751119	T	T	40751119	2	4	276	1	0	0	0	0	0	0	0	1	1299	506	18	4		4	BAHD1	15	40751119	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	76006	40751119	61780273	1455	51344											
CASC5	57082	broad.mit.edu	37	chr15	40915395	40915396	+	Missense_Mutation	DNP	CC	TT	TT																															cagacctaactttgaactatCccaaaggaaaagcctaggaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:40915395_40915396CC>TT	uc010bbs.1	+	11	3172_3173	c.3011_3012CC>TT	c.(3010-3012)TCC>TTT	p.S1004F	CASC5_uc010ucq.1_Missense_Mutation_p.S828F|CASC5_uc001zme.2_Missense_Mutation_p.S978F|CASC5_uc010bbt.1_Missense_Mutation_p.S978F	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	1004	2 X 104 AA approximate repeats.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TTTGAACTATCCCAAAGGAAAA	0.391													4	56					0	0	0	0	TT	40915396	TT	TT	40915395	3	4	276	1	0	0	0	0	1	0	0	0	2675	855	30	2	3049	2	CASC5	15	40915395	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	164276	40915395	61615997	1456	51345											
CASC5	57082	broad.mit.edu	37	chr15	40917521	40917521	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atataaatcacttagaaactCagccggtctctagcaaagat	16	10	6	9	1	3	2	2	0	1	2	4	2	3	2	1	1	3	1	1	1	7	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:40917521C>T	uc010bbs.1	+	11	5298	c.5137C>T	c.(5137-5139)CAG>TAG	p.Q1713*	CASC5_uc010ucq.1_Nonsense_Mutation_p.Q1537*|CASC5_uc001zme.2_Nonsense_Mutation_p.Q1687*|CASC5_uc010bbt.1_Nonsense_Mutation_p.Q1687*	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	1713					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		CTTAGAAACTCAGCCGGTCTC	0.398													15	105					0	0	0	0	T	40917521	T	T	40917521	4	4	276	1	0	0	0	0	0	1	0	0	2675	827	29	2	5175	2	CASC5	15	40917521	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2126	40917521	61613871	1457	51346											
VPS18	57617	broad.mit.edu	37	chr15	41191637	41191637	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtccagcacctgtgtgctcCcttgaggccgagcggggccc	4	7	15	15	2	0	1	0	1	0	0	2	2	2	1	5	4	3	2	5	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:41191637C>T	uc001zne.2	+	4	960	c.621C>T	c.(619-621)TCC>TCT	p.S207S		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	207					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CTGTGTGCTCCCTTGAGGCCG	0.612													31	118					0	0	0	0	T	41191637	T	T	41191637	2	4	276	1	0	0	0	0	0	0	0	1	17262	610	22	4		4	VPS18	15	41191637	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	274116	41191637	61339755	1458	51347											
NDUFAF1	51103	broad.mit.edu	37	chr15	41687185	41687185	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgaccatccccacgtacacGgagatacagagtattgaact	13	7	8	13	3	0	3	0	1	0	2	1	5	1	3	4	1	3	2	4	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:41687185G>A	uc001znx.2	-	3	1013	c.631C>T	c.(631-633)CGT>TGT	p.R211C	NDUFAF1_uc010bcf.2_RNA	NM_016013	NP_057097	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	211					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			ovary(1)	1		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		CCACGTACACGGAGATACAGA	0.433													35	35					0	0	0	0	A	41687185	A	A	41687185	3	1	276	1	0	0	0	0	1	0	0	0	10328	1116	39	1	364	1	NDUFAF1	15	41687185	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	495548	41687185	60844207	1459	51348											
LTK	4058	broad.mit.edu	37	chr15	41805298	41805298	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaaagtctcctgggaccccgGgctagagcagagaatggcgc	11	5	14	11	2	1	2	0	0	1	2	2	4	1	3	3	3	1	2	3	3	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:41805298G>A	uc001zoa.3	-	2	242	c.64C>T	c.(64-66)CCG>TCG	p.P22S	LTK_uc001zob.3_Missense_Mutation_p.P22S|LTK_uc010ucx.1_Missense_Mutation_p.P22S|LTK_uc010bcg.2_Intron	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	22	Extracellular (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		TGGGACCCCGGGCTAGAGCAG	0.612										TSP Lung(18;0.14)			11	9					0	0	0	0	A	41805298	A	A	41805298	3	1	276	1	0	0	0	0	1	0	0	0	9130	1232	43	4	2606	4	LTK	15	41805298	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	118113	41805298	60726094	1460	51349											
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42138473	42138474	+	Missense_Mutation	DNP	CC	TT	TT																															caggatagctgagtttttcaCcgatcttctgacgtggcgtc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:42138473_42138474CC>TT	uc010bco.2	+	17	1774_1775	c.1673_1674CC>TT	c.(1672-1674)ACC>ATT	p.T558I	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.T789I|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.T789I|JMJD7-PLA2G4B_uc001zoq.3_Missense_Mutation_p.T259I|JMJD7-PLA2G4B_uc001zor.1_3'UTR	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	558	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						GAGTTTTTCACCGATCTTCTGA	0.535													19	131					0	0	0	0	TT	42138474	TT	TT	42138473	3	4	276	1	0	0	0	0	1	0	0	0	7994	507	18	4	2452	4	JMJD7-PLA2G4B	15	42138473	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	333175	42138473	60392919	1461	51350											
SPTBN5	51332	broad.mit.edu	37	chr15	42149210	42149210	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagggccgtcctgcgctcCtgcaggggctccctcaggct	3	8	13	17	2	1	0	1	0	0	0	5	0	5	0	5	4	2	4	5	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:42149210C>T	uc001zos.2	-	52	8877	c.8544G>A	c.(8542-8544)CAG>CAA	p.Q2848Q		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2883	Spectrin 25.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TCCTGCGCTCCTGCAGGGGCT	0.647													3	7					0	0	0	0	T	42149210	T	T	42149210	2	4	276	1	0	0	0	0	0	0	0	1	15188	680	24	4		4	SPTBN5	15	42149210	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	10737	42149210	60382182	1462	51351											
EHD4	30844	broad.mit.edu	37	chr15	42192957	42192957	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaggtgcttggccagcgcGaactcctcctcatcaagcat	9	9	10	13	2	2	1	2	1	0	0	4	2	4	1	3	2	4	2	3	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:42192957G>A	uc001zot.2	-	6	1575	c.1512C>T	c.(1510-1512)TTC>TTT	p.F504F		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	504	EF-hand.|EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		TGGCCAGCGCGAACTCCTCCT	0.637													11	38					0	0	0	0	A	42192957	A	A	42192957	2	1	276	1	0	0	0	0	0	0	0	1	5002	1049	37	1		1	EHD4	15	42192957	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	43747	42192957	60338435	1463	51352											
MAP1A	4130	broad.mit.edu	37	chr15	43815393	43815393	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccccaagtacagctatccaGggaacaccaccctctgttcc	10	7	6	18	0	1	0	0	0	1	0	3	1	3	1	6	1	3	3	6	1	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:43815393G>A	uc001zrt.2	+	4	2189	c.1722G>A	c.(1720-1722)CAG>CAA	p.Q574Q		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	574						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CAGCTATCCAGGGAACACCAC	0.542													33	34					0	0	0	0	A	43815393	A	A	43815393	2	1	276	1	0	0	0	0	0	0	0	1	9280	991	35	4		4	MAP1A	15	43815393	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1622436	43815393	58715999	1464	51353											
MAP1A	4130	broad.mit.edu	37	chr15	43819158	43819158	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctaagctcatgccacacatGaagaatgaacccactactcc	14	7	5	15	0	1	3	1	2	0	1	2	3	2	3	4	0	4	1	4	0	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:43819158G>A	uc001zrt.2	+	4	5954	c.5487G>A	c.(5485-5487)ATG>ATA	p.M1829I		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1829						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TGCCACACATGAAGAATGAAC	0.602													29	105					0	0	0	0	A	43819158	A	A	43819158	3	1	276	1	0	0	0	0	1	0	0	0	9280	1290	45	2	5489	2	MAP1A	15	43819158	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3765	43819158	58712234	1465	51354											
SPG11	80208	broad.mit.edu	37	chr15	44881481	44881481	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agatgctctctttcaacaaaGagctgtaaaagcttccccag	13	10	7	11	0	2	2	1	0	1	2	4	2	3	2	2	0	4	4	2	0	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:44881481G>A	uc001ztx.2	-	28	4906	c.4875C>T	c.(4873-4875)CTC>CTT	p.L1625L	SPG11_uc010ueh.1_Silent_p.L1625L|SPG11_uc010uei.1_Silent_p.L1625L|SPG11_uc001zty.1_Silent_p.L354L	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1625	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TTTCAACAAAGAGCTGTAAAA	0.408													16	77					0	0	0	0	A	44881481	A	A	44881481	2	1	276	1	0	0	0	0	0	0	0	1	15107	929	33	2		2	SPG11	15	44881481	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1062323	44881481	57649911	1466	51355											
SPG11	80208	broad.mit.edu	37	chr15	44918568	44918568	+	Frame_Shift_Del	DEL	C	-	-																															gaggcttcctttatattgttCttttttaaattgtcaaagac																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:44918568delC	uc001ztx.2	-	11	2236	c.2205delG	c.(2203-2205)AAGfs	p.K735fs	SPG11_uc010ueh.1_Frame_Shift_Del_p.K735fs|SPG11_uc010uei.1_Frame_Shift_Del_p.K735fs|SPG11_uc001zua.1_Frame_Shift_Del_p.K735fs	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	735	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TTATATTGTTCTTTTTTAAAT	0.313													---	---	---								-	44918568	-	-	44918568	7	5	276	1	0	1	0	1	0	0	0	0	15107	912	32	0	5246	0	SPG11	15	44918568	Frame_Shift_Del	DEL	C	TCGA-D6-6516-01A-11D-1870-08	37087	44918568	57612824	1467	51356											
C15orf48	84419	broad.mit.edu	37	chr15	45723009	45723009	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcatcatgagctttttccaActcctgatgaaaaggaagga	13	11	9	8	0	2	3	2	3	0	0	4	5	4	5	2	2	2	1	2	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:45723009A>G	uc001zvg.2	+	2	133	c.15A>G	c.(13-15)CAA>CAG	p.Q5Q	C15orf48_uc001zvh.2_Silent_p.Q5Q|MIR147B_hsa-mir-147b|MI0005544_5'Flank	NM_197955	NP_922946	Q9C002	NMES1_HUMAN	normal mucosa of esophagus specific 1	5						nucleus				ovary(1)	1		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.67e-16)|GBM - Glioblastoma multiforme(94;1.71e-06)		GCTTTTTCCAACTCCTGATGA	0.368											OREG0023107	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	39					0	0	0	0	G	45723009	G	G	45723009	2	3	276	1	0	0	0	0	0	0	0	1	1805	40	2	5		5	C15orf48	15	45723009	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	804441	45723009	56808383	1468	51357											
SLC30A4	7782	broad.mit.edu	37	chr15	45803391	45803391	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgattttgatgatagccaCaaagcaagcagggtgagtat	13	10	13	5	0	0	4	0	4	0	0	0	4	0	4	1	2	3	3	1	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:45803391C>A	uc001zvj.2	-	3	795	c.483G>T	c.(481-483)TTG>TTT	p.L161F	C15orf21_uc001zvk.2_RNA|C15orf21_uc010beg.1_RNA|C15orf21_uc010beh.1_RNA|C15orf21_uc010bei.1_RNA|C15orf21_uc010bej.1_RNA|C15orf21_uc001zvm.1_RNA|C15orf21_uc001zvn.1_RNA	NM_013309	NP_037441	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter),	161	Helical; (Potential).				regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity				0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)		ATGATAGCCACAAAGCAAGCA	0.373													43	332					1.00776e-21	1.04698e-21	1	0	A	45803391	A	A	45803391	3	1	276	1	0	0	0	0	1	0	0	0	14621	477	17	4	830	4	SLC30A4	15	45803391	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	80382	45803391	56728001	1469	51358											
SEMA6D	80031	broad.mit.edu	37	chr15	48058129	48058129	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttggataaagatcaccaCgctttatatgtggcgttctc	10	13	9	9	2	2	1	1	0	1	1	3	2	2	2	1	2	0	3	1	2	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:48058129C>T	uc010bek.2	+	14	1851	c.1491C>T	c.(1489-1491)CAC>CAT	p.H497H	SEMA6D_uc001zvw.2_Silent_p.H497H|SEMA6D_uc001zvy.2_Silent_p.H497H|SEMA6D_uc001zvz.2_Silent_p.H497H|SEMA6D_uc001zwa.2_Silent_p.H497H|SEMA6D_uc001zwb.2_Silent_p.H497H|SEMA6D_uc001zwc.2_Silent_p.H497H	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	497	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		AAGATCACCACGCTTTATATG	0.413													21	97					0	0	0	0	T	48058129	T	T	48058129	2	4	276	1	0	0	0	0	0	0	0	1	14107	535	19	1		1	SEMA6D	15	48058129	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2254738	48058129	54473263	1470	51359											
MYEF2	50804	broad.mit.edu	37	chr15	48460949	48460949	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccgaattcttgtcttttgaAtaaggatgaaatctattggc	11	15	8	7	1	3	2	0	2	3	0	3	4	3	3	1	2	0	0	1	2	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:48460949A>T	uc001zwi.3	-	2	373	c.249T>A	c.(247-249)TAT>TAA	p.Y83*	MYEF2_uc001zwj.3_Nonsense_Mutation_p.Y83*|MYEF2_uc001zwl.2_5'UTR	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	83					transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		TGTCTTTTGAATAAGGATGAA	0.363													16	94					0	0	0	0	T	48460949	T	T	48460949	4	4	276	1	0	0	0	0	0	1	0	0	10077	108	4	5	1617	5	MYEF2	15	48460949	Nonsense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	402820	48460949	54070443	1471	51360											
CEP152	22995	broad.mit.edu	37	chr15	49030960	49030960	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cattttcactttccattagtGgattgcatttatatactttt	9	21	4	7	0	1	0	1	0	0	0	2	1	2	1	1	1	2	1	1	1	4	11			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:49030960G>A	uc001zwy.2	-	26	4485	c.4451C>T	c.(4450-4452)CCA>CTA	p.P1484L	CEP152_uc001zwz.2_Missense_Mutation_p.P1540L	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1484					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TTCCATTAGTGGATTGCATTT	0.418													10	87					0	0	0	0	A	49030960	A	A	49030960	3	1	276	1	0	0	0	0	1	0	0	0	3263	1348	47	4	517	4	CEP152	15	49030960	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	570011	49030960	53500432	1472	51361											
SECISBP2L	9728	broad.mit.edu	37	chr15	49284871	49284871	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catccaaagagccagtctctGtactctgctgtgaggcccat	9	10	9	13	0	2	2	0	1	2	1	4	2	3	2	3	1	3	2	3	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:49284871G>T	uc001zxe.1	-	18	3010	c.2876C>A	c.(2875-2877)ACA>AAA	p.T959K	SECISBP2L_uc001zxd.1_Missense_Mutation_p.T914K	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	959										breast(1)|skin(1)	2						GCCAGTCTCTGTACTCTGCTG	0.478													19	94					3.32936e-07	3.38678e-07	1	0	T	49284871	T	T	49284871	3	4	276	1	0	0	0	0	1	0	0	0	14072	1377	48	4	433	4	SECISBP2L	15	49284871	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	253911	49284871	53246521	1473	51362											
COPS2	9318	broad.mit.edu	37	chr15	49436470	49436470	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcagtgctttaaatcccCattctcctttttcaccttca	7	18	3	13	0	4	0	3	0	1	0	6	0	5	0	4	0	1	2	4	0	2	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:49436470C>T	uc001zxf.2	-	3	279	c.200G>A	c.(199-201)TGG>TAG	p.W67*	COPS2_uc001zxh.2_Nonsense_Mutation_p.W67*|COPS2_uc010ufa.1_Intron	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	67					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		TTTAAATCCCCATTCTCCTTT	0.289													31	63					0	0	0	0	T	49436470	T	T	49436470	4	4	276	1	0	0	0	0	0	1	0	0	3748	595	21	4	1196	4	COPS2	15	49436470	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	151599	49436470	53094922	1474	51363											
C15orf33	196951	broad.mit.edu	37	chr15	49800528	49800528	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccagtggatccaaaagcCtttttgaggttttaaacctg	10	15	8	8	0	0	1	0	1	0	0	2	2	2	2	4	2	2	1	4	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:49800528C>T	uc001zxl.2	-	11	1186	c.892G>A	c.(892-894)GGC>AGC	p.G298S	C15orf33_uc001zxm.2_Missense_Mutation_p.G264S	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	298										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		ATCCAAAAGCCTTTTTGAGGT	0.313													10	112					0	0	0	0	T	49800528	T	T	49800528	3	4	276	1	0	0	0	0	1	0	0	0	1797	681	24	4	658	4	C15orf33	15	49800528	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	364058	49800528	52730864	1475	51364											
CYP19A1	1588	broad.mit.edu	37	chr15	51534993	51534993	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaggatgtgccctcataattCcacaccaagagaaaaaggcc	15	6	9	11	0	1	1	1	0	0	1	2	4	2	2	4	2	1	0	4	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:51534993C>T	uc001zyz.3	-	3	368	c.117G>A	c.(115-117)TGG>TGA	p.W39*	CYP19A1_uc001zza.3_Nonsense_Mutation_p.W39*|CYP19A1_uc001zzb.2_Nonsense_Mutation_p.W39*|CYP19A1_uc001zzd.2_Nonsense_Mutation_p.W39*|CYP19A1_uc010bey.1_Nonsense_Mutation_p.W39*|CYP19A1_uc001zze.1_RNA	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	39					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	CCTCATAATTCCACACCAAGA	0.443													34	30					0	0	0	0	T	51534993	T	T	51534993	4	4	276	1	0	0	0	0	0	1	0	0	4165	856	30	2	1430	2	CYP19A1	15	51534993	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1734465	51534993	50996399	1476	51365											
WDR72	256764	broad.mit.edu	37	chr15	53901735	53901735	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagactggtctctccaacagGaaattagcttcaaaagtgaa	15	9	8	9	0	2	2	1	1	1	1	4	3	3	3	1	2	2	1	1	2	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:53901735G>A	uc002acj.2	-	17	2969	c.2927C>T	c.(2926-2928)TCC>TTC	p.S976F		NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	976										lung(1)|skin(1)	2				all cancers(107;0.0511)		TCTCCAACAGGAAATTAGCTT	0.388													14	33					0	0	0	0	A	53901735	A	A	53901735	3	1	276	1	0	0	0	0	1	0	0	0	17390	1174	41	2	397	2	WDR72	15	53901735	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2366742	53901735	48629657	1477	51366											
RFX7	64864	broad.mit.edu	37	chr15	56535387	56535387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctggcagcccgggcacaaGggctggcagggccacccccg	6	2	15	18	2	0	0	0	0	0	0	0	0	0	0	5	5	1	4	5	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:56535387G>A	uc010bfn.2	-	1	97	c.97C>T	c.(97-99)CTT>TTT	p.L33F		NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						CCGGGCACAAGGGCTGGCAGG	0.637													3	19					0	0	0	0	A	56535387	A	A	56535387	3	1	276	1	0	0	0	0	1	0	0	0	13333	1000	35	4	4321	4	RFX7	15	56535387	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2633652	56535387	45996005	1478	51367											
MNS1	55329	broad.mit.edu	37	chr15	56756290	56756291	+	Frame_Shift_Del	DEL	GC	-	-																															aataatctgagaaattgcttGcgctgaacacggttatcatt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:56756290_56756291delGC	uc002adr.2	-	2	323_324	c.158_159delGC	c.(157-159)CGCfs	p.R53fs	MNS1_uc010bfo.2_5'UTR	NM_018365	NP_060835	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	53	Potential.				meiosis					ovary(1)	1				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		GAAATTGCTTGCGCTGAACACG	0.327													---	---	---								-	56756291	-	-	56756290	7	5	276	1	0	1	0	1	0	0	0	0	9730	1306	46	0	1364	0	MNS1	15	56756290	Frame_Shift_Del	DEL	GC	TCGA-D6-6516-01A-11D-1870-08	220903	56756290	45775102	1479	51368											
ZNF280D	54816	broad.mit.edu	37	chr15	56981653	56981653	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggacgttttgataaaaatGaactttcactcatacctaca	16	12	5	8	1	2	2	2	2	0	0	2	3	2	3	1	1	3	1	1	1	7	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:56981653G>A	uc002adu.2	-	8	732	c.515C>T	c.(514-516)TCA>TTA	p.S172L	ZNF280D_uc002adv.2_Missense_Mutation_p.S159L|ZNF280D_uc010bfq.2_Missense_Mutation_p.S172L|ZNF280D_uc002adw.1_Missense_Mutation_p.S200L|ZNF280D_uc010bfr.1_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		TGATAAAAATGAACTTTCACT	0.274													4	42					0	0	0	0	A	56981653	A	A	56981653	3	1	276	1	0	0	0	0	1	0	0	0	17884	1294	45	2	2484	2	ZNF280D	15	56981653	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	225363	56981653	45549739	1480	51369											
RNF111	54778	broad.mit.edu	37	chr15	59383308	59383308	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aatgtcaatcgtggagcatcCcaggggacaattgaaagatg	14	8	12	7	1	1	2	1	1	0	1	3	4	2	4	1	3	1	1	1	3	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:59383308C>T	uc002afv.2	+	12	2973	c.2694C>T	c.(2692-2694)TCC>TCT	p.S898S	RNF111_uc002afs.2_Silent_p.S898S|RNF111_uc002aft.2_Silent_p.S907S|RNF111_uc002afu.2_Silent_p.S897S|RNF111_uc002afw.2_Silent_p.S907S|RNF111_uc002afx.2_Silent_p.S424S|RNF111_uc002afy.2_Silent_p.S49S	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	898					multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		GTGGAGCATCCCAGGGGACAA	0.338													29	169					0	0	0	0	T	59383308	T	T	59383308	2	4	276	1	0	0	0	0	0	0	0	1	13490	610	22	4		4	RNF111	15	59383308	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2401655	59383308	43148084	1481	51370											
FAM81A	145773	broad.mit.edu	37	chr15	59752317	59752317	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcagaaaatgcaaaacaaagGgggaggtgaccgcttggcca	15	4	14	8	1	0	2	0	1	0	1	0	3	0	3	2	4	2	3	2	4	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:59752317G>A	uc002agc.2	+	3	393	c.206G>A	c.(205-207)GGG>GAG	p.G69E	FAM81A_uc010uha.1_Missense_Mutation_p.G69E	NM_152450	NP_689663	Q8TBF8	FA81A_HUMAN	hypothetical protein LOC145773	69										ovary(1)	1						CAAAACAAAGGGGGAGGTGAC	0.478													26	125					0	0	0	0	A	59752317	A	A	59752317	3	1	276	1	0	0	0	0	1	0	0	0	5660	1232	43	4	212	4	FAM81A	15	59752317	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	369009	59752317	42779075	1482	51371											
VPS13C	54832	broad.mit.edu	37	chr15	62165597	62165597	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgattcgagatacaactcCtgctgcaccacctatcaaag	12	9	8	12	1	1	2	1	1	0	1	3	3	2	2	3	1	4	2	3	1	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:62165597C>T	uc002agz.2	-	78	10500	c.10426G>A	c.(10426-10428)GGA>AGA	p.G3476R	VPS13C_uc002aha.2_Missense_Mutation_p.G3433R|VPS13C_uc002ahb.1_Missense_Mutation_p.G3476R|VPS13C_uc002ahc.1_Missense_Mutation_p.G3433R	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3476					protein localization					ovary(2)	2						GATACAACTCCTGCTGCacca	0.234													24	183					0	0	0	0	T	62165597	T	T	62165597	3	4	276	1	0	0	0	0	1	0	0	0	17259	690	24	4	895	4	VPS13C	15	62165597	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2413280	62165597	40365795	1483	51372											
HERC1	8925	broad.mit.edu	37	chr15	63943520	63943520	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atttgccactgatactccagGaaactggtgagaaacttgga	13	10	10	8	0	0	2	0	2	0	1	1	5	1	4	2	3	4	0	2	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:63943520G>A	uc002amp.2	-	53	10626	c.10478C>T	c.(10477-10479)TCC>TTC	p.S3493F		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3493	WD 5.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GATACTCCAGGAAACTGGTGA	0.438													31	78					0	0	0	0	A	63943520	A	A	63943520	3	1	276	1	0	0	0	0	1	0	0	0	7096	1174	41	2	4211	2	HERC1	15	63943520	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1777923	63943520	38587872	1484	51373											
ZNF609	23060	broad.mit.edu	37	chr15	64791535	64791535	+	5'Flank	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtactgaccaatgtggcaggTctgagaacatagctgaagct	12	9	12	8	0	1	3	0	3	1	1	1	4	1	3	1	2	4	4	1	2	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:64791535T>G	uc002ann.2	+						ZNF609_uc010bgy.2_5'UTR	NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609							nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ATGTGGCAGGTCTGAGAACAT	0.448													6	20					0	0	0	0	G	64791535	G	G	64791535	1	3	276	0	1	0	0	0	0	0	0	0	18102	1682	58	5		5	ZNF609	15	64791535	5'Flank	SNP	T	TCGA-D6-6516-01A-11D-1870-08	848015	64791535	37739857	1485	51374											
IGDCC3	9543	broad.mit.edu	37	chr15	65622173	65622173	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgtctggttggcggcctcctCcttccggcagtcacatggtg	3	11	13	14	3	2	0	1	0	1	0	5	0	5	0	4	5	0	2	4	5	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:65622173C>T	uc002aos.2	-	12	2140	c.1888G>A	c.(1888-1890)GAG>AAG	p.E630K	IGDCC3_uc002aor.1_5'Flank	NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	630	Extracellular (Potential).									ovary(3)	3						GCGGCCTCCTCCTTCCGGCAG	0.612													15	61					0	0	0	0	T	65622173	T	T	65622173	3	4	276	1	0	0	0	0	1	0	0	0	7607	864	30	2	568	2	IGDCC3	15	65622173	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	830638	65622173	36909219	1486	51375											
TIPIN	54962	broad.mit.edu	37	chr15	66645208	66645209	+	Frame_Shift_Del	DEL	GA	-	-																															tctggagaggctggaggtggGaaaggaggaaaagtttcatc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:66645208_66645209delGA	uc002apr.2	-	2	163_164	c.77_78delTC	c.(76-78)TTCfs	p.F26fs	TIPIN_uc010ujn.1_5'Flank|TIPIN_uc010ujo.1_5'UTR	NM_017858	NP_060328	Q9BVW5	TIPIN_HUMAN	TIMELESS interacting protein	26					cell division|DNA replication checkpoint|intra-S DNA damage checkpoint|mitosis|positive regulation of cell proliferation|regulation of DNA replication involved in S phase|replication fork protection	cytoplasm|nuclear chromatin	protein binding			ovary(1)	1						CTGGAGGTGGGAAAGGAGGAAA	0.411													---	---	---								-	66645209	-	-	66645208	7	5	276	1	0	1	0	1	0	0	0	0	15991	1165	41	0	855	0	TIPIN	15	66645208	Frame_Shift_Del	DEL	GA	TCGA-D6-6516-01A-11D-1870-08	1023035	66645208	35886184	1487	51376											
LBXCOR1	390598	broad.mit.edu	37	chr15	68118621	68118621	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catctcgtcgcgccgctgcgGcatgatcactaagcgagagg	8	7	13	13	6	2	2	1	1	1	1	4	3	2	2	1	2	2	2	1	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:68118621G>A	uc002aqy.1	+	2	428	c.428G>A	c.(427-429)GGC>GAC	p.G143D		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	152					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						CGCCGCTGCGGCATGATCACT	0.662													20	54					0	0	0	0	A	68118621	A	A	68118621	3	1	276	1	0	0	0	0	1	0	0	0	8695	1203	42	4	434	4	LBXCOR1	15	68118621	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1473413	68118621	34412771	1488	51377											
KIF23	9493	broad.mit.edu	37	chr15	69714072	69714072	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctaatcccttggtcaatgaCctcattcatggcaaaaatgg	12	11	8	10	0	3	1	3	1	0	0	4	1	4	1	2	3	0	2	2	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:69714072C>T	uc002asb.2	+	4	414	c.297C>T	c.(295-297)GAC>GAT	p.D99D	KIF23_uc002asc.2_Silent_p.D99D|KIF23_uc010bii.2_Missense_Mutation_p.T35I|KIF23_uc010ukc.1_5'Flank|KIF23_uc010bih.1_RNA	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	99	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						TGGTCAATGACCTCATTCATG	0.353													13	99					0	0	0	0	T	69714072	T	T	69714072	2	4	276	1	0	0	0	0	0	0	0	1	8330	506	18	4		4	KIF23	15	69714072	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1595451	69714072	32817320	1489	51378											
MYO9A	4649	broad.mit.edu	37	chr15	72141213	72141213	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacgaatcagtgacaacctGgtctttgccttattctcagc	9	13	7	12	1	3	1	2	1	2	0	4	2	3	1	2	1	4	0	2	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:72141213G>T	uc002atl.3	-	39	7283	c.6810C>A	c.(6808-6810)ACC>ACA	p.T2270T	MYO9A_uc002atj.2_Silent_p.T183T|MYO9A_uc002atk.2_Silent_p.T1065T	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	2270	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GTGACAACCTGGTCTTTGCCT	0.383													14	75					2.62699e-14	2.70815e-14	1	0	T	72141213	T	T	72141213	2	4	276	1	0	0	0	0	0	0	0	1	10137	1335	47	4		4	MYO9A	15	72141213	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2427141	72141213	30390179	1490	51379											
BBS4	585	broad.mit.edu	37	chr15	73028232	73028232	+	Silent	SNP	C	A	A																															cagggcgagaagaagaacgcCctggcccaatatcaggagat																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:73028232C>A	uc002avb.2	+	14	1216	c.1173C>A	c.(1171-1173)GCC>GCA	p.A391A	BBS4_uc010ukv.1_Silent_p.A379A|BBS4_uc002avc.2_Silent_p.A219A|BBS4_uc002avd.2_Silent_p.A399A	NM_033028	NP_149017	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	391	TPR 10.|Required for localization to centrosomes.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity				0						AGAAGAACGCCCTGGCCCAAT	0.483									Bardet-Biedl_syndrome				30	149					1.88708e-17	1.95492e-17	1	0	A	73028232	A	A	73028232	2	1	276	1	0	0	0	0	0	0	0	1	1341	610	22	4		4	BBS4	15	73028232	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	887019	73028232	29503160	1491	51380	116	2									
BBS4	585	broad.mit.edu	37	chr15	73028238	73028238	+	Silent	SNP	C	T	T																															gagaagaagaacgccctggcCcaatatcaggagatggagaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:73028238C>T	uc002avb.2	+	14	1222	c.1179C>T	c.(1177-1179)GCC>GCT	p.A393A	BBS4_uc010ukv.1_Silent_p.A381A|BBS4_uc002avc.2_Silent_p.A221A|BBS4_uc002avd.2_Silent_p.A401A	NM_033028	NP_149017	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	393	TPR 10.|Required for localization to centrosomes.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity				0						ACGCCCTGGCCCAATATCAGG	0.463									Bardet-Biedl_syndrome				81	91					0	0	0	0	T	73028238	T	T	73028238	2	4	276	1	0	0	0	0	0	0	0	1	1341	610	22	4		4	BBS4	15	73028238	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6	73028238	29503154	1492	51381	116	2									
GOLGA6A	342096	broad.mit.edu	37	chr15	74365149	74365149	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttctggtggctggcagcttCtaggtgctcctaaggggacg	5	11	16	9	1	2	0	0	0	2	0	3	1	3	1	1	6	2	5	1	6	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:74365149C>T	uc002axa.1	-	13	1476	c.1435G>A	c.(1435-1437)GAA>AAA	p.E479K		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	479	Potential.										0						CTGGCAGCTTCTAGGTGCTCC	0.617													18	102					0	0	0	0	T	74365149	T	T	74365149	3	4	276	1	0	0	0	0	1	0	0	0	6594	922	32	2	670	2	GOLGA6A	15	74365149	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1336911	74365149	28166243	1493	51382											
ISLR2	57611	broad.mit.edu	37	chr15	74425963	74425963	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagagccaccggttctgagcGgggaggacgacggggttggg	7	6	20	8	4	1	2	0	1	1	1	1	5	1	4	2	7	2	2	2	7	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:74425963G>A	uc002axd.2	+	4	1637	c.868G>A	c.(868-870)GGG>AGG	p.G290R	ISLR2_uc002axe.2_Missense_Mutation_p.G290R|ISLR2_uc010bjg.2_Missense_Mutation_p.G290R|ISLR2_uc010bjf.2_Missense_Mutation_p.G290R	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	290	Ig-like.|Extracellular (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						GGTTCTGAGCggggaggacga	0.458													4	21					0	0	0	0	A	74425963	A	A	74425963	3	1	276	1	0	0	0	0	1	0	0	0	7898	1116	39	1	870	1	ISLR2	15	74425963	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	60814	74425963	28105429	1494	51383											
ISLR2	57611	broad.mit.edu	37	chr15	74427025	74427025	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagaagcgcatcgccgcaGacttcgacccgcgtgcttcg	7	7	13	14	7	0	2	0	0	0	2	3	4	0	2	2	1	2	3	2	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:74427025G>A	uc002axd.2	+	4	2699	c.1930G>A	c.(1930-1932)GAC>AAC	p.D644N	ISLR2_uc002axe.2_Missense_Mutation_p.D644N|ISLR2_uc010bjg.2_Missense_Mutation_p.D644N|ISLR2_uc010bjf.2_Missense_Mutation_p.D644N	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	644	Cytoplasmic (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						CATCGCCGCAGACTTCGACCC	0.687											OREG0023277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	47					0	0	0	0	A	74427025	A	A	74427025	3	1	276	1	0	0	0	0	1	0	0	0	7898	942	33	2	1932	2	ISLR2	15	74427025	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1062	74427025	28104367	1495	51384											
ISLR	3671	broad.mit.edu	37	chr15	74467477	74467477	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccgcacggtggccgccggagCcctggcctctctgagccatc	4	6	13	18	4	1	1	0	1	1	0	3	2	1	2	6	4	2	1	6	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:74467477C>T	uc002axg.1	+	2	560	c.278C>T	c.(277-279)GCC>GTC	p.A93V	ISLR_uc002axh.1_Missense_Mutation_p.A93V	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	93	LRR 2.				cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						GCCGCCGGAGCCCTGGCCTCT	0.632													6	50					0	0	0	0	T	74467477	T	T	74467477	3	4	276	1	0	0	0	0	1	0	0	0	7897	739	26	4	280	4	ISLR	15	74467477	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	40452	74467477	28063915	1496	51385											
CCDC33	80125	broad.mit.edu	37	chr15	74565168	74565168	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctgcccatcaccccactgtCcttccctatcccgtccatga	6	10	5	20	1	1	1	1	1	0	0	5	1	5	1	7	0	1	1	7	0	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:74565168C>T	uc002axo.2	+	7	1089	c.695C>T	c.(694-696)TCC>TTC	p.S232F	CCDC33_uc002axp.2_Missense_Mutation_p.S54F	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	435							protein binding			ovary(3)|skin(2)	5						ACCCCACTGTCCTTCCCTATC	0.617													16	76					0	0	0	0	T	74565168	T	T	74565168	3	4	276	1	0	0	0	0	1	0	0	0	2819	855	30	2	721	2	CCDC33	15	74565168	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	97691	74565168	27966224	1497	51386											
C15orf39	56905	broad.mit.edu	37	chr15	75503393	75503393	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcccacctggggccacaagtCctcaagaccagaccagccct	10	4	9	18	0	1	2	1	0	0	2	2	2	2	2	7	2	1	0	7	2	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:75503393C>T	uc002azp.3	+	3	3400	c.3080C>T	c.(3079-3081)TCC>TTC	p.S1027F	C15orf39_uc002azq.3_Missense_Mutation_p.S1027F|C15orf39_uc002azr.3_3'UTR	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	1027											0						GGCCACAAGTCCTCAAGACCA	0.637													7	30					0	0	0	0	T	75503393	T	T	75503393	3	4	276	1	0	0	0	0	1	0	0	0	1799	855	30	2	3086	2	C15orf39	15	75503393	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	938225	75503393	27027999	1498	51387											
SIN3A	25942	broad.mit.edu	37	chr15	75702498	75702498	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggagctgttggcatctggtaGgaattgtccaaactctgaca	10	11	12	8	0	2	1	0	1	2	0	3	3	3	3	1	4	2	4	1	4	3	3	rs139503359		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:75702498G>A	uc002bai.2	-	7	1397	c.1138C>T	c.(1138-1140)CTA>TTA	p.L380L	SIN3A_uc002baj.2_Silent_p.L380L|SIN3A_uc010uml.1_Silent_p.L380L	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	380	PAH 2.|Interaction with REST (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						GCATCTGGTAGGAATTGTCCA	0.403													20	109					0	0	0	0	A	75702498	A	A	75702498	2	1	276	1	0	0	0	0	0	0	0	1	14390	991	35	4		4	SIN3A	15	75702498	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	199105	75702498	26828894	1499	51388											
LINGO1	84894	broad.mit.edu	37	chr15	77906818	77906818	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acctccagcgtgccatcaggGaagactgtgagccgcccatt	9	7	11	14	2	1	2	1	1	0	1	2	3	2	3	5	1	3	0	5	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:77906818G>A	uc002bct.1	-	2	1483	c.1431C>T	c.(1429-1431)TTC>TTT	p.F477F	LINGO1_uc002bcu.1_Silent_p.F471F	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	477	Extracellular (Potential).|Ig-like C2-type.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						TGCCATCAGGGAAGACTGTGA	0.677													6	40					0	0	0	0	A	77906818	A	A	77906818	2	1	276	1	0	0	0	0	0	0	0	1	8856	1165	41	2		2	LINGO1	15	77906818	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2204320	77906818	24624574	1500	51389											
KIAA1024	23251	broad.mit.edu	37	chr15	79750223	79750223	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccaacagcaagggagacaaGggcaaccggcctgaaaacac	16	1	11	13	1	0	2	0	1	0	1	0	3	0	2	3	3	4	2	3	3	6	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:79750223G>A	uc002bew.1	+	2	1809	c.1734G>A	c.(1732-1734)AAG>AAA	p.K578K	KIAA1024_uc010unk.1_Silent_p.K578K	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	578						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						AGGGAGACAAGGGCAACCGGC	0.522													42	32					0	0	0	0	A	79750223	A	A	79750223	2	1	276	1	0	0	0	0	0	0	0	1	8244	991	35	4		4	KIAA1024	15	79750223	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1843405	79750223	22781169	1501	51390											
IL16	3603	broad.mit.edu	37	chr15	81584977	81584977	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agaactcagcacccccgcatCgcagggctcagaaggtcatg	11	5	11	14	2	3	2	3	0	0	2	4	2	3	2	2	2	2	4	2	2	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:81584977C>T	uc002bgh.3	+	12	1877	c.1501C>T	c.(1501-1503)CGC>TGC	p.R501C	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.R501C|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.R543C|IL16_uc002bgg.2_Missense_Mutation_p.R501C|IL16_uc002bgi.1_5'UTR|IL16_uc002bgj.2_5'UTR|IL16_uc002bgk.2_5'Flank	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	501					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						ACCCCCGCATCGCAGGGCTCA	0.602													15	58					0	0	0	0	T	81584977	T	T	81584977	3	4	276	1	0	0	0	0	1	0	0	0	7672	884	31	1	1543	1	IL16	15	81584977	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1834754	81584977	20946415	1502	51391											
CPEB1	64506	broad.mit.edu	37	chr15	83226687	83226688	+	Missense_Mutation	DNP	GG	AA	AA																															tccagaggcaggaagctcaaGgggggttttcctaggacatt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:83226687_83226688GG>AA	uc002bit.2	-	4	745_746	c.608_609CC>TT	c.(607-609)CCC>CTT	p.P203L	CPEB1_uc002biq.2_Missense_Mutation_p.P68L|CPEB1_uc002bir.2_Missense_Mutation_p.P68L|CPEB1_uc002bis.2_Missense_Mutation_p.P68L|CPEB1_uc010uod.1_Intron|CPEB1_uc010uoe.1_Missense_Mutation_p.P146L|CPEB1_uc002biu.2_Missense_Mutation_p.P170L|CPEB1_uc010uof.1_Missense_Mutation_p.P68L|CPEB1_uc002biv.2_Missense_Mutation_p.P143L|CPEB1_uc002bip.2_5'Flank	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	143					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGAAGCTCAAGGGGGGTTTTCC	0.53													48	33					0	0	0	0	AA	83226688	AA	AA	83226687	3	1	276	1	0	0	0	0	1	0	0	0	3815	987	35	4	1307	4	CPEB1	15	83226687	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	1641710	83226687	19304705	1503	51392											
AP3B2	8120	broad.mit.edu	37	chr15	83331552	83331552	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggagaagtggatgtgcacGgacaccatgtggggatcccc	9	8	15	9	1	0	1	0	0	0	1	1	5	1	4	3	5	1	1	3	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:83331552G>A	uc010uoh.1	-	22	2847	c.2670C>T	c.(2668-2670)TCC>TCT	p.S890S	AP3B2_uc010uoi.1_Silent_p.S909S|AP3B2_uc010uoj.1_Silent_p.S858S|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Silent_p.S526S	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	890					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGATGTGCACGGACACCATGT	0.612													25	8					0	0	0	0	A	83331552	A	A	83331552	2	1	276	1	0	0	0	0	0	0	0	1	745	1103	39	1		1	AP3B2	15	83331552	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	104865	83331552	19199840	1504	51393											
AP3B2	8120	broad.mit.edu	37	chr15	83335576	83335576	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catggcggctgagggccccaCcctgctcggaagggacgatg	7	5	16	13	3	0	1	0	1	0	0	1	4	0	3	3	5	1	2	3	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:83335576C>T	uc010uoh.1	-	15	1952	c.1775G>A	c.(1774-1776)GGT>GAT	p.G592D	AP3B2_uc010uoi.1_Missense_Mutation_p.G592D|AP3B2_uc010uoj.1_Missense_Mutation_p.G560D|AP3B2_uc010uog.1_Missense_Mutation_p.G228D	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	592					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			GAGGGCCCCACCCTGCTCGGA	0.572													33	65					0	0	0	0	T	83335576	T	T	83335576	3	4	276	1	0	0	0	0	1	0	0	0	745	507	18	4	1521	4	AP3B2	15	83335576	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4024	83335576	19195816	1505	51394											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84568476	84568476	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaccagaatagcaacagaaGaaccaacgtgagtccaggac	18	3	10	10	1	0	5	0	1	0	4	1	6	1	6	3	1	4	1	3	1	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:84568476G>A	uc002bjz.3	+	15	1917	c.1693G>A	c.(1693-1695)GAA>AAA	p.E565K	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.E565K|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.E565K	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	565	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCAACAGAAGAACCAACGTG	0.373													11	3					0	0	0	0	A	84568476	A	A	84568476	3	1	276	1	0	0	0	0	1	0	0	0	276	943	33	2	1747	2	ADAMTSL3	15	84568476	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1232900	84568476	17962916	1506	51395											
ALPK3	57538	broad.mit.edu	37	chr15	85382230	85382230	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatacccagagccagaggtGacctggtacaaggatgatac	13	6	13	9	0	0	4	0	2	0	2	0	6	0	6	3	4	4	1	3	4	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:85382230G>T	uc002ble.2	+	4	1097	c.930G>T	c.(928-930)GTG>GTT	p.V310V		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	310	Ig-like 1.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCCAGAGGTGACCTGGTACA	0.458													12	20					1.49906e-05	1.52065e-05	1	0	T	85382230	T	T	85382230	2	4	276	1	0	0	0	0	0	0	0	1	546	1277	45	2		2	ALPK3	15	85382230	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	813754	85382230	17149162	1507	51396											
C15orf42	90381	broad.mit.edu	37	chr15	90167625	90167625	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccctgttccctcaactcccCctgaactctcacagagagct	8	9	6	18	0	2	2	2	1	1	1	5	3	4	2	4	0	3	2	4	0	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:90167625C>T	uc002boe.2	+	20	4084	c.4084C>T	c.(4084-4086)CCT>TCT	p.P1362S	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1362	Pro-rich.				cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CTCAACTCCCCCTGAACTCTC	0.532													41	115					0	0	0	0	T	90167625	T	T	90167625	3	4	276	1	0	0	0	0	1	0	0	0	1802	623	22	4	4162	4	C15orf42	15	90167625	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4785395	90167625	12363767	1508	51397											
SEMA4B	10509	broad.mit.edu	37	chr15	90770854	90770854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagcgcgtcttcggttgtgtCcccgtcttttgtaccaacag	5	13	10	13	4	2	0	0	0	2	0	4	0	3	0	3	1	3	2	3	1	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:90770854C>T	uc002boy.2	+	14	2037	c.1754C>T	c.(1753-1755)TCC>TTC	p.S585F	SEMA4B_uc002boz.2_Missense_Mutation_p.S585F|SEMA4B_uc010uqd.1_Missense_Mutation_p.S423F|SEMA4B_uc002bpa.2_Missense_Mutation_p.S423F|SEMA4B_uc010bnv.1_Missense_Mutation_p.S223F	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			TCGGTTGTGTCCCCGTCTTTT	0.592													16	40					0	0	0	0	T	90770854	T	T	90770854	3	4	276	1	0	0	0	0	1	0	0	0	14097	855	30	2	1804	2	SEMA4B	15	90770854	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	603229	90770854	11760538	1509	51398											
CHD2	1106	broad.mit.edu	37	chr15	93527664	93527665	+	Missense_Mutation	DNP	GG	AA	AA																															caaaggaaaaaagtagaggaGgaagagcggcagaaggagct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:93527664_93527665GG>AA	uc002bsp.2	+	25	3746_3747	c.3171_3172GG>AA	c.(3169-3174)GAGGAA>GAAAAA	p.E1058K	CHD2_uc002bso.1_Missense_Mutation_p.E1058K	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1058	Glu-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AAGTAGAGGAGGAAGAGCGGCA	0.416													26	7					0	0	0	0	AA	93527665	AA	AA	93527664	3	1	276	1	0	0	0	0	1	0	0	0	3340	991	35	4	3269	4	CHD2	15	93527664	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	2756810	93527664	9003728	1510	51399											
SPATA8	145946	broad.mit.edu	37	chr15	97326937	97326937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acaactcctgtctctaccagGaaattgccccctcttttcag	9	12	5	15	0	3	0	1	0	2	0	5	1	4	1	4	1	3	0	4	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:97326937G>A	uc002bue.2	+	1	262	c.52G>A	c.(52-54)GAA>AAA	p.E18K	uc010uro.1_5'Flank|uc010urp.1_5'Flank|uc002bud.1_5'Flank	NM_173499	NP_775770	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	18										ovary(1)|skin(1)	2	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			TCTCTACCAGGAAATTGCCCC	0.552													21	47					0	0	0	0	A	97326937	A	A	97326937	3	1	276	1	0	0	0	0	1	0	0	0	15081	1175	41	2	54	2	SPATA8	15	97326937	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3799273	97326937	5204455	1511	51400											
IGF1R	3480	broad.mit.edu	37	chr15	99467122	99467122	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagaaggagcagatgacattCctgggccagtgacctgggag	11	6	15	9	0	0	4	0	2	0	2	1	6	1	6	3	3	1	1	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:99467122C>T	uc002bul.2	+	12	2553	c.2503C>T	c.(2503-2505)CCT>TCT	p.P835S	IGF1R_uc010bon.2_Missense_Mutation_p.P835S|IGF1R_uc010boo.1_5'Flank	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	835	Extracellular (Potential).|Fibronectin type-III 3.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	AGATGACATTCCTGGGCCAGT	0.473													47	25					0	0	0	0	T	99467122	T	T	99467122	3	4	276	1	0	0	0	0	1	0	0	0	7610	855	30	2	2549	2	IGF1R	15	99467122	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2140185	99467122	3064270	1512	51401											
ADAMTS17	170691	broad.mit.edu	37	chr15	100514651	100514651	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catcttgtttgcatagaagtCcctgcaggtctggcagcagc	8	11	11	11	0	2	1	0	0	2	1	3	1	3	1	1	2	4	5	1	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:100514651C>T	uc002bvv.1	-	22	3323	c.3244G>A	c.(3244-3246)GAC>AAC	p.D1082N	ADAMTS17_uc002bvw.1_RNA	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1082	PLAC.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		GCATAGAAGTCCCTGCAGGTC	0.587													8	55					0	0	0	0	T	100514651	T	T	100514651	3	4	276	1	0	0	0	0	1	0	0	0	262	855	30	2	47	2	ADAMTS17	15	100514651	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1047529	100514651	2016741	1513	51402											
LRRK1	79705	broad.mit.edu	37	chr15	101528995	101528996	+	Missense_Mutation	DNP	CC	TT	TT																															ccctgtcatcgtgcgcttgcCcctgtatgcggccatcaagt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:101528995_101528996CC>TT	uc002bwr.2	+	5	909_910	c.590_591CC>TT	c.(589-591)CCC>CTT	p.P197L	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bwq.1_Missense_Mutation_p.P197L	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	197	ANK 4.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTGCGCTTGCCCCTGTATGCGG	0.589													14	7					0	0	0	0	TT	101528996	TT	TT	101528995	3	4	276	1	0	0	0	0	1	0	0	0	9082	623	22	4	604	4	LRRK1	15	101528995	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1014344	101528995	1002397	1514	51403											
LRRK1	79705	broad.mit.edu	37	chr15	101592030	101592030	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgagaaatcagaggatgTgcagtacttcgacatggaag	14	8	13	6	1	1	2	1	1	0	2	2	6	1	4	0	2	2	2	0	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:101592030T>G	uc002bwr.2	+	24	3873	c.3554T>G	c.(3553-3555)GTG>GGG	p.V1185G	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_5'Flank	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1185					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TCAGAGGATGTGCAGTACTTC	0.642													11	25					0	0	0	0	G	101592030	G	G	101592030	3	3	276	1	0	0	0	0	1	0	0	0	9082	1696	59	5	3644	5	LRRK1	15	101592030	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	63035	101592030	939362	1515	51404											
LRRK1	79705	broad.mit.edu	37	chr15	101606368	101606368	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcagccagcacctgcaggCcgtgaagatcctcgccgtca	8	7	10	16	3	2	2	2	1	0	1	4	2	3	2	5	1	3	2	5	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:101606368C>T	uc002bwr.2	+	32	6045	c.5726C>T	c.(5725-5727)GCC>GTC	p.A1909V	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1909					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CACCTGCAGGCCGTGAAGATC	0.637													14	68					0	0	0	0	T	101606368	T	T	101606368	3	4	276	1	0	0	0	0	1	0	0	0	9082	739	26	4	5848	4	LRRK1	15	101606368	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	14338	101606368	925024	1516	51405											
PCSK6	5046	broad.mit.edu	37	chr15	101906410	101906410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagccactgaccttgcttctCcgggttgcggacctgggatg	5	10	14	12	2	1	1	0	1	1	0	2	4	1	3	4	3	3	2	4	3	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr15:101906410C>T	uc002bwy.2	-	14	2163	c.1849G>A	c.(1849-1851)GAG>AAG	p.E617K	PCSK6_uc010bpd.2_Missense_Mutation_p.E413K|PCSK6_uc010bpe.2_Missense_Mutation_p.E617K|PCSK6_uc002bxa.2_Missense_Mutation_p.E617K|PCSK6_uc002bxb.2_Missense_Mutation_p.E617K|PCSK6_uc002bxc.1_Missense_Mutation_p.E617K|PCSK6_uc002bxd.1_Missense_Mutation_p.E617K|PCSK6_uc002bxe.2_Missense_Mutation_p.E617K|PCSK6_uc002bxf.1_Missense_Mutation_p.E117K	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	617	Homo B/P.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCTTGCTTCTCCGGGTTGCGG	0.488													8	18					0	0	0	0	T	101906410	T	T	101906410	3	4	276	1	0	0	0	0	1	0	0	0	11658	864	30	2	1529	2	PCSK6	15	101906410	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	300042	101906410	624982	1517	51406											
AXIN1	8312	broad.mit.edu	37	chr16	343668	343668	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cggcccaggggtgctcaaggGacaagggtctggagttctca	8	7	16	10	1	3	0	2	0	2	0	4	2	3	2	1	6	1	2	1	6	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:343668G>A	uc002cgp.1	-	8	2183	c.2006C>T	c.(2005-2007)TCC>TTC	p.S669F	AXIN1_uc002cgq.1_Missense_Mutation_p.S669F	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	669	Interaction with RNF111.|Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GTGCTCAAGGGACAAGGGTCT	0.642													58	113					0	0	0	0	A	343668	A	A	343668	3	1	276	1	0	0	0	0	1	0	0	0	1238	1174	41	2	598	2	AXIN1	16	343668	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08		343668	90011085	1518	51407											
AXIN1	8312	broad.mit.edu	37	chr16	396971	396971	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cactgggggtcggggagcatCttcggtgaaacttgctccga	7	9	15	10	3	1	1	0	1	1	0	4	3	2	2	1	5	3	2	1	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:396971C>T	uc002cgp.1	-	2	232	c.55G>A	c.(55-57)GAT>AAT	p.D19N	AXIN1_uc002cgq.1_Missense_Mutation_p.D19N	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	19					activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CGGGGAGCATCTTCGGTGAAA	0.567													32	54					0	0	0	0	T	396971	T	T	396971	3	4	276	1	0	0	0	0	1	0	0	0	1238	913	32	2	2573	2	AXIN1	16	396971	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	53303	396971	89957782	1519	51408											
MSLNL	401827	broad.mit.edu	37	chr16	819554	819554	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acagaaaccaggatgcaagtCccccagtgcagcaggcacag	14	3	11	13	0	0	1	0	0	0	1	1	2	1	2	3	2	4	4	3	2	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:819554C>T	uc002cjz.1	-	16	3036	c.3036G>A	c.(3034-3036)GGG>GGA	p.G1012G	MIR662_hsa-mir-662|MI0003670_5'Flank	NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	661	Helical; (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						GGATGCAAGTCCCCCAGTGCA	0.632													8	41					0	0	0	0	T	819554	T	T	819554	2	4	276	1	0	0	0	0	0	0	0	1	9935	842	30	2		2	MSLNL	16	819554	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	422583	819554	89535199	1520	51409											
MSLNL	401827	broad.mit.edu	37	chr16	830222	830222	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccggggcatccgggtccCagggtggacctgtgaccccc	4	5	17	15	2	0	1	0	1	0	0	2	2	2	2	6	6	0	1	6	6	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:830222C>T	uc002cjz.1	-	3	779	c.779G>A	c.(778-780)TGG>TAG	p.W260*		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4						ATCCGGGTCCCAGGGTGGACC	0.672													7	11					0	0	0	0	T	830222	T	T	830222	4	4	276	1	0	0	0	0	0	1	0	0	9935	595	21	4	2438	4	MSLNL	16	830222	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	10668	830222	89524531	1521	51410											
PRR25	388199	broad.mit.edu	37	chr16	863384	863384	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaccgacacggcctccccatCcctgggtccaccccgactcc	6	5	8	22	3	0	0	0	0	0	0	4	3	4	0	9	2	0	0	9	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:863384C>T	uc010uut.1	+	3	732	c.732C>T	c.(730-732)ATC>ATT	p.I244I		NM_001013638	NP_001013660	Q96S07	PRR25_HUMAN	proline rich 25	244										large_intestine(1)	1						GCCTCCCCATCCCTGGGTCCA	0.697													3	6					0	0	0	0	T	863384	T	T	863384	2	4	276	1	0	0	0	0	0	0	0	1	12659	845	30	2		2	PRR25	16	863384	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	33162	863384	89491369	1522	51411											
ZNF598	90850	broad.mit.edu	37	chr16	2049627	2049627	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgggggcactccgagcaggGgccgggccctccatgtgtcc	4	7	16	14	2	0	0	0	0	0	0	3	1	3	0	5	5	1	2	5	5	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:2049627G>A	uc002cof.1	-	11	1938	c.1923C>T	c.(1921-1923)GCC>GCT	p.A641A	ZNF598_uc002coe.1_Silent_p.A5A	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	641	Pro-rich.					intracellular	zinc ion binding			lung(1)|breast(1)	2						TCCGAGCAGGGGCCGGGCCCT	0.711													6	27					0	0	0	0	A	2049627	A	A	2049627	2	1	276	1	0	0	0	0	0	0	0	1	18095	1219	43	4		4	ZNF598	16	2049627	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1186243	2049627	88305126	1523	51412											
PKD1	5310	broad.mit.edu	37	chr16	2158531	2158532	+	Missense_Mutation	DNP	GG	AA	AA																															cggcagcaccagccgaggccGgctcacgtccacgccgggca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:2158531_2158532GG>AA	uc002cos.1	-	15	6845_6846	c.6636_6637CC>TT	c.(6634-6639)AGCCGG>AGTTGG	p.R2213W	PKD1_uc002cot.1_Missense_Mutation_p.R2213W	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2213	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						AGCCGAGGCCGGCTCACGTCCA	0.678													11	23					0	0	0	0	AA	2158532	AA	AA	2158531	3	1	276	1	0	0	0	0	1	0	0	0	12018	1115	39	1	6402	1	PKD1	16	2158531	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	108904	2158531	88196222	1524	51413											
PKD1	5310	broad.mit.edu	37	chr16	2158553	2158553	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcacgtccacgccgggcagGgccacacgcgctgggcgccc	5	3	14	19	6	1	0	1	0	0	0	2	0	2	0	4	3	0	2	4	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:2158553G>A	uc002cos.1	-	15	6824	c.6615C>T	c.(6613-6615)GCC>GCT	p.A2205A	PKD1_uc002cot.1_Silent_p.A2205A	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2205	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CGCCGGGCAGGGCCACACGCG	0.687													5	21					0	0	0	0	A	2158553	A	A	2158553	2	1	276	1	0	0	0	0	0	0	0	1	12018	1219	43	4		4	PKD1	16	2158553	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	22	2158553	88196200	1525	51414											
TBC1D24	57465	broad.mit.edu	37	chr16	2546623	2546623	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcgagaaggcctgccgcatCctggcctgcaatgaccccgg	7	7	12	15	3	0	2	0	1	0	1	2	3	1	2	6	3	2	2	6	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:2546623C>T	uc002cql.2	+	2	614	c.474C>T	c.(472-474)ATC>ATT	p.I158I	TBC1D24_uc002cqk.2_Silent_p.I158I|TBC1D24_uc002cqm.2_Silent_p.I158I|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	158	Rab-GAP TBC.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						CCTGCCGCATCCTGGCCTGCA	0.642													10	26					0	0	0	0	T	2546623	T	T	2546623	2	4	276	1	0	0	0	0	0	0	0	1	15680	845	30	2		2	TBC1D24	16	2546623	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	388070	2546623	87808130	1526	51415											
PDPK1	5170	broad.mit.edu	37	chr16	2607890	2607890	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctgcagcatgcccagcctCcgccgcagcctcggaagaag	8	4	11	18	3	0	1	0	0	0	1	2	2	1	2	6	1	5	3	6	1	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:2607890C>T	uc002cqs.2	+	2	355	c.211C>T	c.(211-213)CCG>TCG	p.P71S	PDPK1_uc002cqt.2_Missense_Mutation_p.P71S|PDPK1_uc010bsn.2_Missense_Mutation_p.P71S|PDPK1_uc002cqu.2_Missense_Mutation_p.P44S|PDPK1_uc002cqv.1_Missense_Mutation_p.P44S|PDPK1_uc010uwe.1_Missense_Mutation_p.P71S|uc010bso.1_5'Flank	NM_002613	NP_002604	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	71					actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|ovary(1)	3		Ovarian(90;0.17)			Celecoxib(DB00482)	TGCCCAGCCTCCGCCGCAGCC	0.657													4	53					0	0	0	0	T	2607890	T	T	2607890	3	4	276	1	0	0	0	0	1	0	0	0	11741	855	30	2	217	2	PDPK1	16	2607890	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	61267	2607890	87746863	1527	51416											
SRRM2	23524	broad.mit.edu	37	chr16	2813122	2813122	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccaggccaatgagcaatctGtaacgccacagagacggagc	13	4	11	13	2	1	2	0	1	1	1	1	4	1	3	3	2	3	2	3	2	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:2813122G>T	uc002crk.2	+	11	3142	c.2593G>T	c.(2593-2595)GTA>TTA	p.V865L	SRRM2_uc002crj.1_Missense_Mutation_p.V769L|SRRM2_uc002crl.1_Missense_Mutation_p.V865L|SRRM2_uc010bsu.1_Missense_Mutation_p.V769L	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	865	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TGAGCAATCTGTAACGCCACA	0.493													51	92					3.10996e-30	3.24295e-30	1	0	T	2813122	T	T	2813122	3	4	276	1	0	0	0	0	1	0	0	0	15235	1377	48	4	2631	4	SRRM2	16	2813122	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	205232	2813122	87541631	1528	51417											
FLYWCH2	114984	broad.mit.edu	37	chr16	2946651	2946651	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgtgcactgtgtcatgtcCctgggggtgcccggccccgc	2	9	16	14	2	1	0	1	0	0	0	2	0	2	0	4	4	2	1	4	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:2946651C>T	uc002csa.2	+	3	572	c.201C>T	c.(199-201)TCC>TCT	p.S67S	FLYWCH2_uc010uwj.1_Silent_p.S67S|FLYWCH2_uc010uwk.1_Silent_p.S67S	NM_138439	NP_612448	Q96CP2	FWCH2_HUMAN	FLYWCH family member 2	67											0						GTGTCATGTCCCTGGGGGTGC	0.667													33	52					0	0	0	0	T	2946651	T	T	2946651	2	4	276	1	0	0	0	0	0	0	0	1	5980	610	22	4		4	FLYWCH2	16	2946651	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	133529	2946651	87408102	1529	51418											
CCDC64B	146439	broad.mit.edu	37	chr16	3079404	3079404	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggctgggggctggacgcCtttcgggtctttggggaccg	4	9	19	9	3	1	0	0	0	1	0	2	3	1	2	2	7	0	2	2	7	1	2	rs113579453		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:3079404C>T	uc002ctf.3	-	6	1029	c.984G>A	c.(982-984)AAG>AAA	p.K328K	CCDC64B_uc002cte.3_Silent_p.K121K	NM_001103175	NP_001096645	A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	328											0						GGCTGGACGCCTTTCGGGTCT	0.592													6	24					0	0	0	0	T	3079404	T	T	3079404	2	4	276	1	0	0	0	0	0	0	0	1	2849	680	24	4		4	CCDC64B	16	3079404	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	132753	3079404	87275349	1530	51419											
ZNF174	7727	broad.mit.edu	37	chr16	3458635	3458635	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagcaaccgtttgcaacatCttggtcaccagcccacccgc	9	8	8	16	2	2	1	1	1	1	0	2	1	2	1	4	1	5	3	4	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:3458635C>T	uc002cvc.2	+	3	1755	c.940C>T	c.(940-942)CTT>TTT	p.L314F		NM_003450	NP_003441	Q15697	ZN174_HUMAN	zinc finger protein 174 isoform a	314					negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0						TTTGCAACATCTTGGTCACCA	0.493													17	68					0	0	0	0	T	3458635	T	T	3458635	3	4	276	1	0	0	0	0	1	0	0	0	17811	913	32	2	1034	2	ZNF174	16	3458635	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	379231	3458635	86896118	1531	51420											
NLRC3	197358	broad.mit.edu	37	chr16	3613075	3613075	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acgccctggctgaggctcagGgacaggttggcctcctgggc	5	7	16	13	1	1	1	1	1	0	0	2	2	2	2	3	6	0	3	3	6	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:3613075G>A	uc010btn.2	-	5	2274	c.1863C>T	c.(1861-1863)TCC>TCT	p.S621S		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	621	LRR 1.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TGAGGCTCAGGGACAGGTTGG	0.706													3	6					0	0	0	0	A	3613075	A	A	3613075	2	1	276	1	0	0	0	0	0	0	0	1	10522	1219	43	4		4	NLRC3	16	3613075	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	154440	3613075	86741678	1532	51421											
NLRC3	197358	broad.mit.edu	37	chr16	3614430	3614430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggcagcaccagcgagaagtCcttgccgacctgcccatggg	9	5	13	14	2	0	1	0	0	0	1	1	3	1	1	5	2	4	2	5	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:3614430C>T	uc010btn.2	-	5	919	c.508G>A	c.(508-510)GAC>AAC	p.D170N		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	170	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						AGCGAGAAGTCCTTGCCGACC	0.657													4	50					0	0	0	0	T	3614430	T	T	3614430	3	4	276	1	0	0	0	0	1	0	0	0	10522	855	30	2	2754	2	NLRC3	16	3614430	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1355	3614430	86740323	1533	51422											
BTBD12	84464	broad.mit.edu	37	chr16	3639210	3639210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtgcagcttcctcggatggGggtggtgtccaggagtcccg	5	9	17	10	2	0	0	0	0	0	0	4	2	3	2	3	5	2	2	3	5	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:3639210G>A	uc002cvp.2	-	12	5056	c.4429C>T	c.(4429-4431)CCC>TCC	p.P1477S		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1477	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CCTCGGATGGGGGTGGTGTCC	0.662								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				43	223					0	0	0	0	A	3639210	A	A	3639210	3	1	276	1	0	0	0	0	1	0	0	0	1545	1232	43	4	1091	4	BTBD12	16	3639210	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	24780	3639210	86715543	1534	51423											
GLIS2	84662	broad.mit.edu	37	chr16	4385175	4385176	+	Missense_Mutation	DNP	GG	AT	AT																															gggagggctgcgcccgccatGgccgaggtttcaacgccagg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:4385175_4385176GG>AT	uc002cwc.1	+	4	694_695	c.637_638GG>AT	c.(637-639)GGC>ATC	p.G213I		NM_032575	NP_115964	Q9BZE0	GLIS2_HUMAN	GLIS family zinc finger 2	213	C2H2-type 2; atypical.				cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development	cytoplasm|nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|transcription regulatory region DNA binding|zinc ion binding				0						CGCCCGCCATGGCCGAGGTTTC	0.653													23	50					0	0	0	0	AT	4385176	AT	AT	4385175	3	1	276	1	0	0	0	0	1	0	0	0	6483	1348	47	4	651	4	GLIS2	16	4385175	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	745965	4385175	85969578	1535	51424											
SEC14L5	9717	broad.mit.edu	37	chr16	5055947	5055947	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atcaatgagaacaccaggcgGaagttcctcatctacagtgg	13	8	10	10	1	3	1	2	1	1	1	4	3	4	2	2	3	2	1	2	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:5055947G>A	uc002cye.2	+	12	1515	c.1335G>A	c.(1333-1335)CGG>CGA	p.R445R		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	445	CRAL-TRIO.					integral to membrane|intracellular	transporter activity				0						ACACCAGGCGGAAGTTCCTCA	0.433													7	14					0	0	0	0	A	5055947	A	A	5055947	2	1	276	1	0	0	0	0	0	0	0	1	14050	1161	41	2		2	SEC14L5	16	5055947	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	670772	5055947	85298806	1536	51425											
SEC14L5	9717	broad.mit.edu	37	chr16	5058637	5058637	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccccttgtctgccgggagggGgagagcatccaggtttgcat	6	9	15	11	1	1	1	0	0	1	1	2	3	2	2	4	4	3	3	4	4	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:5058637G>A	uc002cye.2	+	14	1968	c.1788G>A	c.(1786-1788)GGG>GGA	p.G596G		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	596	GOLD.					integral to membrane|intracellular	transporter activity				0						GCCGGGAGGGGGAGAGCATCC	0.423													36	64					0	0	0	0	A	5058637	A	A	5058637	2	1	276	1	0	0	0	0	0	0	0	1	14050	1219	43	4		4	SEC14L5	16	5058637	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2690	5058637	85296116	1537	51426											
ABAT	18	broad.mit.edu	37	chr16	8862733	8862734	+	Missense_Mutation	DNP	CC	TT	TT																															tcacaagatcgacatcccttCctttgactggcccatcgcac																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:8862733_8862734CC>TT	uc002czc.3	+	11	885_886	c.719_720CC>TT	c.(718-720)TCC>TTT	p.S240F	ABAT_uc002czd.3_Missense_Mutation_p.S240F|ABAT_uc010buh.2_Missense_Mutation_p.S182F|ABAT_uc010bui.2_Missense_Mutation_p.S240F	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	240					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	GACATCCCTTCCTTTGACTGGC	0.53													117	221					0	0	0	0	TT	8862734	TT	TT	8862733	3	4	276	1	0	0	0	0	1	0	0	0	27	855	30	2	757	2	ABAT	16	8862733	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	3804096	8862733	81492020	1538	51427											
GRIN2A	2903	broad.mit.edu	37	chr16	9892181	9892181	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtcgatctgcctcttccaaGgagagcctttctgaagggca	8	10	12	11	1	3	2	0	1	3	1	5	4	4	2	3	3	2	1	3	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:9892181G>A	uc002czo.3	-	11	2857	c.2309C>T	c.(2308-2310)CCT>CTT	p.P770L	GRIN2A_uc010uym.1_Missense_Mutation_p.P770L|GRIN2A_uc010uyn.1_Missense_Mutation_p.P613L|GRIN2A_uc002czr.3_Missense_Mutation_p.P770L	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	770	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCTCTTCCAAGGAGAGCCTTT	0.557													18	40					0	0	0	0	A	9892181	A	A	9892181	3	1	276	1	0	0	0	0	1	0	0	0	6818	1000	35	4	2097	4	GRIN2A	16	9892181	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1029448	9892181	80462572	1539	51428											
NUBP1	4682	broad.mit.edu	37	chr16	10851749	10851749	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcatgatcaagcagttcctCcgagatgtggactggggaga	10	8	15	8	1	1	3	1	1	0	2	3	6	3	4	2	4	1	3	2	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:10851749C>T	uc002daa.1	+	7	494	c.471C>T	c.(469-471)CTC>CTT	p.L157L	NUBP1_uc010bum.1_Silent_p.L22L|NUBP1_uc002dab.1_Silent_p.L146L	NM_002484	NP_002475	P53384	NUBP1_HUMAN	nucleotide binding protein 1	157					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			ovary(1)|skin(1)	2						AGCAGTTCCTCCGAGATGTGG	0.488													9	128					0	0	0	0	T	10851749	T	T	10851749	2	4	276	1	0	0	0	0	0	0	0	1	10769	842	30	2		2	NUBP1	16	10851749	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	959568	10851749	79503004	1540	51429											
CIITA	4261	broad.mit.edu	37	chr16	10989224	10989224	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agcgatgctgaccccctgtgCctctaccacttctatgacca	8	10	7	16	1	2	2	0	2	2	0	2	3	2	2	5	0	4	1	5	0	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:10989224C>T	uc002dai.3	+	2	271	c.138C>T	c.(136-138)TGC>TGT	p.C46C	CIITA_uc002daj.3_Silent_p.C46C|CIITA_uc002dak.3_Silent_p.C46C|CIITA_uc002dag.2_Silent_p.C46C|CIITA_uc002dah.2_Silent_p.C46C|CIITA_uc010bup.1_Silent_p.C46C	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	46					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						ACCCCCTGTGCCTCTACCACT	0.582			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								7	26					0	0	0	0	T	10989224	T	T	10989224	2	4	276	1	0	0	0	0	0	0	0	1	3443	747	26	4		4	CIITA	16	10989224	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	137475	10989224	79365529	1541	51430											
CIITA	4261	broad.mit.edu	37	chr16	11001414	11001414	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccgcagacgtgaggacctggGcgatggccaaaggcttagtc	9	6	15	11	3	0	2	0	1	0	1	1	4	0	3	3	4	0	2	3	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:11001414G>A	uc002dai.3	+	11	2198	c.2065G>A	c.(2065-2067)GCG>ACG	p.A689T	CIITA_uc002daj.3_Missense_Mutation_p.A690T|CIITA_uc002dak.3_Intron|CIITA_uc002dag.2_Missense_Mutation_p.A689T|CIITA_uc002dah.2_Missense_Mutation_p.A641T|CIITA_uc010bup.1_Intron	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	689	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						GAGGACCTGGGCGATGGCCAA	0.657			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								14	73					0	0	0	0	A	11001414	A	A	11001414	3	1	276	1	0	0	0	0	1	0	0	0	3443	1203	42	4	2107	4	CIITA	16	11001414	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	12190	11001414	79353339	1542	51431											
RSL1D1	26156	broad.mit.edu	37	chr16	11940618	11940618	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcctaattctggcatcagtaAggaagaaatcaaaactgctc	15	9	8	9	0	3	1	2	0	1	1	4	2	3	2	1	2	2	3	1	2	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:11940618A>G	uc002dbp.1	-	4	540	c.467T>C	c.(466-468)CTT>CCT	p.L156P	RSL1D1_uc010buv.1_Missense_Mutation_p.L156P|RSL1D1_uc010uyw.1_5'UTR|RSL1D1_uc010buw.2_RNA	NM_015659	NP_056474	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	156					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						GGCATCAGTAAGGAAGAAATC	0.403													111	214					0	0	0	0	G	11940618	G	G	11940618	3	3	276	1	0	0	0	0	1	0	0	0	13765	72	3	5	1029	5	RSL1D1	16	11940618	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	939204	11940618	78414135	1543	51432											
RUNDC2A	84127	broad.mit.edu	37	chr16	12136911	12136911	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagcgctacctgcacatgctCctggccgaccgctgcaggct	6	7	12	16	3	0	0	0	0	0	0	1	2	1	0	4	2	5	6	4	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:12136911C>T	uc002dbw.1	+	5	467	c.405C>T	c.(403-405)CTC>CTT	p.L135L		NM_032167	NP_115543	Q9HA26	RUN2A_HUMAN	RUN domain containing 2A	135	RUN.									ovary(1)	1						TGCACATGCTCCTGGCCGACC	0.532			T	CIITA	PMBL|Hodgkin Lymphona|								5	21					0	0	0	0	T	12136911	T	T	12136911	2	4	276	1	0	0	0	0	0	0	0	1	13808	842	30	2		2	RUNDC2A	16	12136911	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	196293	12136911	78217842	1544	51433											
KIAA0430	9665	broad.mit.edu	37	chr16	15705498	15705498	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatgacctgtttgctggcctGggatttgagaagttttagta	9	15	12	5	0	0	2	0	2	0	1	0	4	0	3	2	2	1	4	2	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:15705498G>A	uc002ddr.2	-	18	3761	c.3568C>T	c.(3568-3570)CAG>TAG	p.Q1190*	KIAA0430_uc002ddq.2_Nonsense_Mutation_p.Q1024*|KIAA0430_uc010uzv.1_Nonsense_Mutation_p.Q1186*|KIAA0430_uc010uzw.1_Nonsense_Mutation_p.Q1189*	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	1189						peroxisome	nucleotide binding|RNA binding				0						TTGCTGGCCTGGGATTTGAGA	0.423													14	59					0	0	0	0	A	15705498	A	A	15705498	4	1	276	1	0	0	0	0	0	1	0	0	8216	1357	47	4	1700	4	KIAA0430	16	15705498	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3568587	15705498	74649255	1545	51434											
XYLT1	64131	broad.mit.edu	37	chr16	17353019	17353019	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctggtcatacttggtctcggGggagctgcccccagttttcc	4	12	12	13	1	2	0	1	0	1	0	4	1	3	1	3	4	3	2	3	4	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:17353019G>A	uc002dfa.2	-	3	824	c.739C>T	c.(739-741)CCC>TCC	p.P247S		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	247	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						TTGGTCTCGGGGGAGCTGCCC	0.632													57	102					0	0	0	0	A	17353019	A	A	17353019	3	1	276	1	0	0	0	0	1	0	0	0	17531	1232	43	4	2180	4	XYLT1	16	17353019	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1647521	17353019	73001734	1546	51435											
SMG1	23049	broad.mit.edu	37	chr16	18823385	18823385	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtagcaagatttttttggatCagctttctagcattctgtga	9	17	9	6	0	3	2	1	1	2	1	3	3	3	3	0	1	3	4	0	1	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:18823385C>T	uc002dfm.2	-	61	11049	c.10686G>A	c.(10684-10686)CTG>CTA	p.L3562L	SMG1_uc010bwb.2_Silent_p.L3422L|SMG1_uc010bwa.2_Silent_p.L2293L	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3562					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TTTTTTGGATCAGCTTTCTAG	0.463													16	63					0	0	0	0	T	18823385	T	T	18823385	2	4	276	1	0	0	0	0	0	0	0	1	14859	813	29	2		2	SMG1	16	18823385	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1470366	18823385	71531368	1547	51436											
SYT17	51760	broad.mit.edu	37	chr16	19236021	19236021	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcagacccctttgtgaaaatCcagctggtgcatggactcaa	11	10	9	11	0	2	2	2	1	0	1	3	3	3	3	3	2	2	2	3	2	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:19236021C>T	uc002dfw.2	+	7	1420	c.1089C>T	c.(1087-1089)ATC>ATT	p.I363I	SYT17_uc002dfx.2_Silent_p.I302I|SYT17_uc002dfy.2_Silent_p.I359I|SYT17_uc002dfv.1_Silent_p.I302I	NM_016524	NP_057608	Q9BSW7	SYT17_HUMAN	B/K protein	363	C2 2.					membrane|synaptic vesicle	transporter activity			ovary(1)	1						TTGTGAAAATCCAGCTGGTGC	0.408													26	58					0	0	0	0	T	19236021	T	T	19236021	2	4	276	1	0	0	0	0	0	0	0	1	15539	845	30	2		2	SYT17	16	19236021	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	412636	19236021	71118732	1548	51437											
CP110	9738	broad.mit.edu	37	chr16	19553958	19553958	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctaggtttcacaaattctgCcatgcaatatagctttgttt	10	17	6	8	0	3	0	1	0	2	0	3	0	3	0	1	1	3	4	1	1	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:19553958C>T	uc002dgl.3	+	7	2490	c.2243C>T	c.(2242-2244)GCC>GTC	p.A748V	CP110_uc002dgk.3_Missense_Mutation_p.A748V			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	748					centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						ACAAATTCTGCCATGCAATAT	0.373													5	42					0	0	0	0	T	19553958	T	T	19553958	3	4	276	1	0	0	0	0	1	0	0	0	3803	739	26	4	2265	4	CP110	16	19553958	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	317937	19553958	70800795	1549	51438											
ACSM2A	123876	broad.mit.edu	37	chr16	20476956	20476956	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggcagccaacgtcctctcgGgagcctgtggcctgcagcgt	6	7	14	14	3	1	0	0	0	1	0	3	1	2	1	4	3	5	2	4	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:20476956G>A	uc010bwe.2	+	4	534	c.295G>A	c.(295-297)GGA>AGA	p.G99R	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Missense_Mutation_p.G20R|ACSM2A_uc002dhf.3_Missense_Mutation_p.G99R|ACSM2A_uc002dhg.3_Missense_Mutation_p.G99R|ACSM2A_uc010vay.1_Missense_Mutation_p.G20R	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	99					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CGTCCTCTCGGGAGCCTGTGG	0.592													16	51					0	0	0	0	A	20476956	A	A	20476956	3	1	276	1	0	0	0	0	1	0	0	0	183	1233	43	4	301	4	ACSM2A	16	20476956	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	922998	20476956	69877797	1550	51439											
ACSM2A	123876	broad.mit.edu	37	chr16	20487017	20487017	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcgtcactgtaggggagtcCcttcttccagaaactctgga	8	11	11	11	1	3	1	1	0	2	1	5	3	5	3	2	3	2	1	2	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:20487017C>T	uc010bwe.2	+	9	1259	c.1020C>T	c.(1018-1020)TCC>TCT	p.S340S	ACSM2A_uc010vax.1_Silent_p.S261S|ACSM2A_uc002dhf.3_Silent_p.S340S|ACSM2A_uc002dhg.3_Silent_p.S340S|ACSM2A_uc010vay.1_Silent_p.S261S|ACSM2A_uc002dhh.3_5'UTR	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	340					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						TAGGGGAGTCCCTTCTTCCAG	0.522													36	199					0	0	0	0	T	20487017	T	T	20487017	2	4	276	1	0	0	0	0	0	0	0	1	183	610	22	4		4	ACSM2A	16	20487017	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	10061	20487017	69867736	1551	51440											
ZP2	7783	broad.mit.edu	37	chr16	21208925	21208926	+	Missense_Mutation	DNP	CC	TT	TT																															catctccagcagtcttgtgcCctttggtgtccatagcacct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:21208925_21208926CC>TT	uc002dii.2	-	19	2113_2114	c.2113_2114GG>AA	c.(2113-2115)GGG>AAG	p.G705K	ZP2_uc010bwn.1_Missense_Mutation_p.G735K	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	705	Extracellular (Potential).				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		AGTCTTGTGCCCTTTGGTGTCC	0.48													10	72					0	0	0	0	TT	21208926	TT	TT	21208925	3	4	276	1	0	0	0	0	1	0	0	0	18283	623	22	4	127	4	ZP2	16	21208925	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	721908	21208925	69145828	1552	51441											
ZP2	7783	broad.mit.edu	37	chr16	21213521	21213521	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tggcaggatgagtttcccacCctcagagtacccaggtcaag	10	8	11	12	0	2	2	2	1	0	1	3	3	3	3	3	3	1	3	3	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:21213521C>T	uc002dii.2	-	11	1191	c.1191G>A	c.(1189-1191)AGG>AGA	p.R397R	ZP2_uc010bwn.1_Silent_p.R436R	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	397	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		AGTTTCCCACCCTCAGAGTAC	0.532													14	29					0	0	0	0	T	21213521	T	T	21213521	2	4	276	1	0	0	0	0	0	0	0	1	18283	622	22	4		4	ZP2	16	21213521	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4596	21213521	69141232	1553	51442											
GGA2	23062	broad.mit.edu	37	chr16	23499976	23499976	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggagctcttgggccagggaGatggtgggggtaagatttta	8	11	18	4	0	1	2	0	0	1	2	1	4	1	3	1	6	1	2	1	6	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:23499976G>A	uc002dlq.2	-	6	606	c.530C>T	c.(529-531)TCT>TTT	p.S177F	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	177					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		GGGCCAGGGAGATGGTGGGGG	0.418													54	109					0	0	0	0	A	23499976	A	A	23499976	3	1	276	1	0	0	0	0	1	0	0	0	6390	942	33	2	1359	2	GGA2	16	23499976	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2286455	23499976	66854777	1554	51443											
UBFD1	56061	broad.mit.edu	37	chr16	23569515	23569515	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagctggtggacttgaagatCatctggaataagaccaagca	14	8	12	7	0	2	3	1	1	1	2	2	6	2	5	1	3	2	2	1	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:23569515C>T	uc002dlv.2	+	2	472	c.270C>T	c.(268-270)ATC>ATT	p.I90I	EARS2_uc002dls.3_5'Flank|EARS2_uc002dlt.3_5'Flank|EARS2_uc002dlu.2_5'Flank	NM_019116	NP_061989	O14562	UBFD1_HUMAN	ubiquitin-binding protein homolog	90	Ubiquitin-like.										0				GBM - Glioblastoma multiforme(48;0.0331)		ACTTGAAGATCATCTGGAATA	0.637													18	39					0	0	0	0	T	23569515	T	T	23569515	2	4	276	1	0	0	0	0	0	0	0	1	16952	816	29	2		2	UBFD1	16	23569515	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	69539	23569515	66785238	1555	51444											
ERN2	10595	broad.mit.edu	37	chr16	23713533	23713534	+	Missense_Mutation	DNP	CC	TT	TT																															cttgtctctgcagttccactCcccagggtgggatggaccct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:23713533_23713534CC>TT	uc002dma.3	-	11	1455_1456	c.1286_1287GG>AA	c.(1285-1287)GGG>GAA	p.G429E	ERN2_uc010bxp.2_Missense_Mutation_p.G429E|ERN2_uc010bxq.1_Missense_Mutation_p.G237E	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	381	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CAGTTCCACTCCCCAGGGTGGG	0.619													60	111					0	0	0	0	TT	23713534	TT	TT	23713533	3	4	276	1	0	0	0	0	1	0	0	0	5262	842	30	2	1685	2	ERN2	16	23713533	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	144018	23713533	66641220	1556	51445											
SLC5A11	115584	broad.mit.edu	37	chr16	24922733	24922733	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagggcaaggaagagctccCggccagagcagaagccatca	14	2	14	11	1	1	3	1	0	0	3	2	5	2	4	3	3	3	3	3	3	4	0	rs145800390	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:24922733C>T	uc002dmu.2	+	16	2139	c.1907C>T	c.(1906-1908)CCG>CTG	p.P636L	SLC5A11_uc002dms.2_Missense_Mutation_p.P572L|SLC5A11_uc010vcd.1_Missense_Mutation_p.P601L|SLC5A11_uc002dmt.2_Missense_Mutation_p.P480L|SLC5A11_uc010vce.1_Missense_Mutation_p.P566L|SLC5A11_uc010bxt.2_Missense_Mutation_p.P572L|SLC5A11_uc002dmv.2_Missense_Mutation_p.P259L	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	636	Cytoplasmic (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		GAAGAGCTCCCGGCCAGAGCA	0.537													87	156					0	0	0	0	T	24922733	T	T	24922733	3	4	276	1	0	0	0	0	1	0	0	0	14727	652	23	1	1965	1	SLC5A11	16	24922733	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1209200	24922733	65432020	1557	51446											
ZKSCAN2	342357	broad.mit.edu	37	chr16	25264338	25264338	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccattcatcagcaagggcagGaacccagggagaaggccgag	13	3	14	11	1	2	1	2	0	0	1	2	4	2	2	3	4	2	2	3	4	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:25264338G>A	uc002dod.3	-	3	1014	c.607C>T	c.(607-609)CCT>TCT	p.P203S	ZKSCAN2_uc010vcl.1_5'UTR|ZKSCAN2_uc002doe.2_Missense_Mutation_p.P203S	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	203					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		GCAAGGGCAGGAACCCAGGGA	0.428													28	158					0	0	0	0	A	25264338	A	A	25264338	3	1	276	1	0	0	0	0	1	0	0	0	17754	1174	41	2	2316	2	ZKSCAN2	16	25264338	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	341605	25264338	65090415	1558	51447											
SULT1A1	6817	broad.mit.edu	37	chr16	28617420	28617420	+	Silent	SNP	G	A	A																															ctgtggtccatgaactcctgGgggacggtggtgtagttggt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:28617420G>A	uc002dqi.2	-	6	1205	c.732C>T	c.(730-732)CCC>CCT	p.P244P	uc010vct.1_Intron|SULT1A1_uc002dqj.2_Silent_p.P244P|SULT1A1_uc002dqk.2_Silent_p.P244P|SULT1A1_uc002dql.2_Silent_p.P244P|SULT1A1_uc002dqm.2_Silent_p.P166P|SULT1A1_uc002dqn.2_Silent_p.P335P|SULT1A1_uc002dqo.2_Silent_p.P244P|SULT1A1_uc002dqp.2_Silent_p.P244P	NM_177534	NP_803878	P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A,	244					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						TGAACTCCTGGGGGACGGTGG	0.617													27	424					0	0	0	0	A	28617420	A	A	28617420	2	1	276	1	0	0	0	0	0	0	0	1	15438	1219	43	4		4	SULT1A1	16	28617420	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3353082	28617420	61737333	1559	51448	117	2									
SULT1A1	6817	broad.mit.edu	37	chr16	28617426	28617426	+	Silent	SNP	G	A	A																															tccatgaactcctgggggacGgtggtgtagttggtcatagg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:28617426G>A	uc002dqi.2	-	6	1199	c.726C>T	c.(724-726)ACC>ACT	p.T242T	uc010vct.1_Intron|SULT1A1_uc002dqj.2_Silent_p.T242T|SULT1A1_uc002dqk.2_Silent_p.T242T|SULT1A1_uc002dql.2_Silent_p.T242T|SULT1A1_uc002dqm.2_Silent_p.T164T|SULT1A1_uc002dqn.2_Silent_p.T333T|SULT1A1_uc002dqo.2_Silent_p.T242T|SULT1A1_uc002dqp.2_Silent_p.T242T	NM_177534	NP_803878	P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A,	242					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						CCTGGGGGACGGTGGTGTAGT	0.602													27	401					0	0	0	0	A	28617426	A	A	28617426	2	1	276	1	0	0	0	0	0	0	0	1	15438	1103	39	1		1	SULT1A1	16	28617426	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6	28617426	61737327	1560	51449	117	2									
SPN	6693	broad.mit.edu	37	chr16	29675976	29675976	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgggctgggccagcccaggtCcctgaggagggggccgtgac	5	5	19	12	1	0	2	0	2	0	0	1	3	1	3	4	6	1	1	4	6	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:29675976C>T	uc002dtm.2	+	2	1063	c.927C>T	c.(925-927)GTC>GTT	p.V309V	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Silent_p.V309V|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	309	Cytoplasmic (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						CAGCCCAGGTCCCTGAGGAGG	0.731													3	10					0	0	0	0	T	29675976	T	T	29675976	2	4	276	1	0	0	0	0	0	0	0	1	15139	842	30	2		2	SPN	16	29675976	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1058550	29675976	60678777	1561	51450											
TAOK2	9344	broad.mit.edu	37	chr16	29996845	29996846	+	Silent	DNP	CC	TT	TT																															cagaagaaggagctggctgcCctgctggaggcacagaagcg																								rs141623258		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:29996845_29996846CC>TT	uc002dva.1	+	14	2517_2518	c.1734_1735CC>TT	c.(1732-1737)GCCCTG>GCTTTG	p.578_579AL>AL	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Silent_p.578_579AL>AL|TAOK2_uc002dvc.1_Silent_p.578_579AL>AL|TAOK2_uc010bzm.1_Silent_p.585_586AL>AL|TAOK2_uc002dvd.1_Silent_p.405_406AL>AL	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	578_579	Potential.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						AGCTGGCTGCCCTGCTGGAGGC	0.639													6	33					0	0	0	0	TT	29996846	TT	TT	29996845	2	4	276	1	0	0	0	0	0	0	0	1	15614	610	22	4		4	TAOK2	16	29996845	Silent	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	320869	29996845	60357908	1562	51451											
FBXL19	54620	broad.mit.edu	37	chr16	30941539	30941539	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcctcctcggactcagactCcgactccgactcttcgggca	6	10	8	17	4	2	1	1	0	1	1	8	4	6	2	4	2	0	1	4	2	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:30941539C>T	uc002eab.2	+	7	1153	c.995C>T	c.(994-996)TCC>TTC	p.S332F	FBXL19_uc002dzz.1_Missense_Mutation_p.S20F|FBXL19_uc002eaa.1_Missense_Mutation_p.S231F	NM_001099784	NP_001093254	Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	332	Ser-rich.						DNA binding|zinc ion binding			ovary(2)|lung(1)|breast(1)	4						GACTCAGACTCCGACTCCGAC	0.667													14	57					0	0	0	0	T	30941539	T	T	30941539	3	4	276	1	0	0	0	0	1	0	0	0	5747	855	30	2	1021	2	FBXL19	16	30941539	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	944694	30941539	59413214	1563	51452											
HSD3B7	80270	broad.mit.edu	37	chr16	30998163	30998163	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acctgcctttgccaccaggtCcgtggggggctgcccctggt	3	9	14	15	1	0	0	0	0	0	0	1	0	1	0	7	5	3	1	7	5	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:30998163C>T	uc002eaf.2	+	6	640	c.534C>T	c.(532-534)GTC>GTT	p.V178V	HSD3B7_uc010cac.2_Intron|HSD3B7_uc002eag.2_Intron|HSD3B7_uc002eah.2_Silent_p.V178V	NM_025193	NP_079469	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta-	178					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity				0						GCCACCAGGTCCGTGGGGGGC	0.677													9	59					0	0	0	0	T	30998163	T	T	30998163	2	4	276	1	0	0	0	0	0	0	0	1	7431	842	30	2		2	HSD3B7	16	30998163	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	56624	30998163	59356590	1564	51453											
STX4	6810	broad.mit.edu	37	chr16	31046325	31046325	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaggaggaagctgatgagaaCtataactccgtcaacacaag	17	6	10	8	1	1	2	1	2	0	1	2	5	2	4	1	2	4	1	1	2	7	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:31046325C>T	uc002eal.2	+	5	566	c.342C>T	c.(340-342)AAC>AAT	p.N114N	STX4_uc002eak.2_Silent_p.N112N|STX4_uc002eam.2_Silent_p.N36N	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	114	Cytoplasmic (Potential).|Potential.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						CTGATGAGAACTATAACTCCG	0.408													21	129					0	0	0	0	T	31046325	T	T	31046325	2	4	276	1	0	0	0	0	0	0	0	1	15413	564	20	4		4	STX4	16	31046325	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	48162	31046325	59308428	1565	51454											
ITGAD	3681	broad.mit.edu	37	chr16	31414965	31414965	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccacgggcatcctgacagtgGtgtaagcaaccccgacccca	10	5	10	16	2	0	1	0	1	0	0	1	2	1	1	6	2	2	3	6	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:31414965G>A	uc002ebv.1	+	7	752	c.703G>A	c.(703-705)GTG>ATG	p.V235M	ITGAD_uc010vfl.1_Missense_Mutation_p.V235M|ITGAD_uc010cap.1_Missense_Mutation_p.V235M|ITGAD_uc002ebw.1_Missense_Mutation_p.V46M	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	235	Extracellular (Potential).|VWFA.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						CCTGACAGTGGTGTAAGCAAC	0.627													20	48					0	0	0	0	A	31414965	A	A	31414965	3	1	276	1	0	0	0	0	1	0	0	0	7923	1275	44	4	729	4	ITGAD	16	31414965	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	368640	31414965	58939788	1566	51455											
ITGAD	3681	broad.mit.edu	37	chr16	31421727	31421727	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcctcccaggatggcctcttCctgggggctgtggggagctt	3	11	15	12	0	1	0	0	0	1	0	4	2	4	2	4	6	1	2	4	6	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:31421727C>T	uc002ebv.1	+	11	1144	c.1095C>T	c.(1093-1095)TTC>TTT	p.F365F	ITGAD_uc010cap.1_Silent_p.F365F	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	365	Extracellular (Potential).|FG-GAP 3.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						ATGGCCTCTTCCTGGGGGCTG	0.577													24	88					0	0	0	0	T	31421727	T	T	31421727	2	4	276	1	0	0	0	0	0	0	0	1	7923	854	30	2		2	ITGAD	16	31421727	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6762	31421727	58933026	1567	51456											
ITFG1	81533	broad.mit.edu	37	chr16	47345268	47345268	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttgctgttcatccacaaatGgcacaaagccccagagtgtg	11	9	10	11	0	1	1	1	0	0	1	2	1	2	1	3	1	2	4	3	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:47345268G>A	uc002eet.2	-	10	1015	c.953C>T	c.(952-954)CCA>CTA	p.P318L	ITFG1_uc010vgg.1_Missense_Mutation_p.P63L|ITFG1_uc010vgh.1_Missense_Mutation_p.P205L	NM_030790	NP_110417	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	318						extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				ATCCACAAATGGCACAAAGCC	0.393													19	41					0	0	0	0	A	47345268	A	A	47345268	3	1	276	1	0	0	0	0	1	0	0	0	7908	1348	47	4	921	4	ITFG1	16	47345268	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	15923541	47345268	43009485	1568	51457											
ABCC11	85320	broad.mit.edu	37	chr16	48218385	48218385	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgacagccatgactttaaagGagtagggggtggaggaaatg	13	8	16	4	0	0	2	0	2	0	0	0	5	0	5	1	5	1	1	1	5	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:48218385G>A	uc002eff.1	-	22	3574	c.3224C>T	c.(3223-3225)TCC>TTC	p.S1075F	ABCC11_uc002efg.1_Missense_Mutation_p.S1075F|ABCC11_uc002efh.1_Missense_Mutation_p.S1075F|ABCC11_uc010cbg.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	1075	Cytoplasmic (Potential).|ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GACTTTAAAGGAGTAGGGGGT	0.557									Cerumen_Type				14	60					0	0	0	0	A	48218385	A	A	48218385	3	1	276	1	0	0	0	0	1	0	0	0	51	1174	41	2	956	2	ABCC11	16	48218385	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	873117	48218385	42136368	1569	51458											
C16orf78	123970	broad.mit.edu	37	chr16	49430376	49430376	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgacccagagtccactcagcGgccaaacccattccgtcgac	10	5	8	18	4	1	1	1	0	0	1	4	3	3	1	5	1	2	0	5	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:49430376G>A	uc002efr.2	+	4	480	c.437G>A	c.(436-438)CGG>CAG	p.R146Q		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	146										central_nervous_system(1)	1						TCCACTCAGCGGCCAAACCCA	0.507													39	69					0	0	0	0	A	49430376	A	A	49430376	3	1	276	1	0	0	0	0	1	0	0	0	1841	1116	39	1	451	1	C16orf78	16	49430376	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1211991	49430376	40924377	1570	51459											
SALL1	6299	broad.mit.edu	37	chr16	51173737	51173737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggactcagagtagctgtcgGggactggggtgttggggatc	6	10	19	6	1	1	1	1	0	0	1	3	4	1	4	0	7	1	3	0	7	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:51173737G>A	uc010vgs.1	-	2	2427	c.2396C>T	c.(2395-2397)CCC>CTC	p.P799L	SALL1_uc010vgr.1_Missense_Mutation_p.P702L|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	799					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GTAGCTGTCGGGGACTGGGGT	0.502													58	113					0	0	0	0	A	51173737	A	A	51173737	3	1	276	1	0	0	0	0	1	0	0	0	13875	1232	43	4	1586	4	SALL1	16	51173737	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1743361	51173737	39181016	1571	51460											
IRX3	79191	broad.mit.edu	37	chr16	54319187	54319187	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgctcccataagcgtttccCtcctcgtcagtgcggctgcg	4	11	10	16	5	1	0	1	0	0	0	6	0	4	0	3	1	3	3	3	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:54319187C>T	uc002eht.1	-	2	1022	c.606G>A	c.(604-606)GAG>GAA	p.E202E		NM_024336	NP_077312	P78415	IRX3_HUMAN	iroquois homeobox 3	202	Asp/Glu-rich (acidic).				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AAGCGTTTCCCTCCTCGTCAG	0.463													19	27					0	0	0	0	T	54319187	T	T	54319187	2	4	276	1	0	0	0	0	0	0	0	1	7884	680	24	4		4	IRX3	16	54319187	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3145450	54319187	36035566	1572	51461											
IRX6	79190	broad.mit.edu	37	chr16	55362877	55362877	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggatcggaagaagctgacttCctctcggcggagacaggcag	10	6	15	10	3	1	3	0	1	1	2	4	6	2	5	1	5	1	2	1	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:55362877C>T	uc002ehy.2	+	5	1520	c.987C>T	c.(985-987)TTC>TTT	p.F329F	IRX6_uc002ehx.2_Silent_p.F329F	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	329						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						AAGCTGACTTCCTCTCGGCGG	0.647													24	46					0	0	0	0	T	55362877	T	T	55362877	2	4	276	1	0	0	0	0	0	0	0	1	7887	854	30	2		2	IRX6	16	55362877	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1043690	55362877	34991876	1573	51462											
GNAO1	2775	broad.mit.edu	37	chr16	56377846	56377846	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catcgccaaaaacctgcgggGctgtggactctactgagccc	9	7	11	14	2	1	1	0	1	1	0	2	2	1	2	3	3	4	1	3	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:56377846G>A	uc002eit.3	+	8	1946	c.1049G>A	c.(1048-1050)GGC>GAC	p.G350D	GNAO1_uc002eiu.3_Intron	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	350					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				AACCTGCGGGGCTGTGGACTC	0.627													6	54					0	0	0	0	A	56377846	A	A	56377846	3	1	276	1	0	0	0	0	1	0	0	0	6545	1203	42	4	1079	4	GNAO1	16	56377846	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1014969	56377846	33976907	1574	51463											
NLRC5	84166	broad.mit.edu	37	chr16	57088699	57088699	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgtccccgaaaagccccttCctgctggccaacaccttaag	9	8	7	17	1	0	0	0	0	0	0	2	1	2	0	7	1	3	1	7	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:57088699C>T	uc002ekk.1	+	25	3768	c.3543C>T	c.(3541-3543)TTC>TTT	p.F1181F	NLRC5_uc002ekn.2_Silent_p.F900F|NLRC5_uc002ekl.2_Silent_p.F986F|NLRC5_uc002ekm.2_Silent_p.F956F|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekp.1_Silent_p.F97F|NLRC5_uc002ekq.1_5'UTR|NLRC5_uc002ekr.1_Silent_p.F97F	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1181	LRR 12.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				AAAGCCCCTTCCTGCTGGCCA	0.587													46	230					0	0	0	0	T	57088699	T	T	57088699	2	4	276	1	0	0	0	0	0	0	0	1	10524	854	30	2		2	NLRC5	16	57088699	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	710853	57088699	33266054	1575	51464											
CPNE2	221184	broad.mit.edu	37	chr16	57151428	57151428	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcgctgcccaggagctgtcCgacaaccgcgtcatcacact	9	7	9	16	4	2	0	2	0	0	0	4	2	3	1	3	1	3	2	3	1	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:57151428C>T	uc002eks.1	+	5	685	c.456C>T	c.(454-456)TCC>TCT	p.S152S	CPNE2_uc010cct.1_Silent_p.S178S|CPNE2_uc010ccu.1_Silent_p.S152S	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	152	C2 2.									central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				AGGAGCTGTCCGACAACCGCG	0.652													8	27					0	0	0	0	T	57151428	T	T	57151428	2	4	276	1	0	0	0	0	0	0	0	1	3827	639	23	1		1	CPNE2	16	57151428	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	62729	57151428	33203325	1576	51465											
CCDC113	29070	broad.mit.edu	37	chr16	58287927	58287927	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggcaggcgtagatccaaatCccggacaggtatggaccgtg	11	6	14	10	3	0	1	0	0	0	1	2	3	2	3	3	5	0	3	3	5	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:58287927C>T	uc002ene.2	+	3	333	c.254C>T	c.(253-255)TCC>TTC	p.S85F	CCDC113_uc010vid.1_Intron	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	85						protein complex					0						AGATCCAAATCCCGGACAGGT	0.493													9	74					0	0	0	0	T	58287927	T	T	58287927	3	4	276	1	0	0	0	0	1	0	0	0	2762	855	30	2	264	2	CCDC113	16	58287927	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1136499	58287927	32066826	1577	51466											
NDRG4	65009	broad.mit.edu	37	chr16	58537726	58537726	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgacatcgagacaccctacGgccttctgcatgtagtgatc	10	10	9	12	2	1	3	0	2	1	1	3	4	1	3	2	1	2	2	2	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:58537726G>A	uc002eno.2	+	2	152	c.46G>A	c.(46-48)GGC>AGC	p.G16S	NDRG4_uc002enk.2_Missense_Mutation_p.G48S|NDRG4_uc002enm.2_Missense_Mutation_p.G68S|NDRG4_uc010vif.1_Missense_Mutation_p.G48S|NDRG4_uc010cdk.2_Missense_Mutation_p.G16S|NDRG4_uc010vig.1_Missense_Mutation_p.G46S|NDRG4_uc010vih.1_5'UTR|NDRG4_uc010vii.1_Missense_Mutation_p.G34S|NDRG4_uc002enp.2_Missense_Mutation_p.G16S|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	16					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1						GACACCCTACGGCCTTCTGCA	0.622													8	51					0	0	0	0	A	58537726	A	A	58537726	3	1	276	1	0	0	0	0	1	0	0	0	10308	1116	39	1	216	1	NDRG4	16	58537726	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	249799	58537726	31817027	1578	51467											
CDH8	1006	broad.mit.edu	37	chr16	61859073	61859073	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccatgttgggaagggcagtTtttataatagctgaggggga	10	12	15	4	0	0	1	0	1	0	0	1	3	1	3	1	4	1	4	1	4	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:61859073T>A	uc002eog.1	-	5	930	c.678A>T	c.(676-678)AAA>AAT	p.K226N	CDH8_uc002eoh.2_5'UTR	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	226	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GAAGGGCAGTTTTTATAATAG	0.448													18	44					0	0	0	0	A	61859073	A	A	61859073	3	1	276	1	0	0	0	0	1	0	0	0	3131	1838	64	5	1753	5	CDH8	16	61859073	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	3321347	61859073	28495680	1579	51468											
CDH11	1009	broad.mit.edu	37	chr16	65006865	65006865	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtttcctctctatccagaggTtttgtagttttaataaaacc	10	17	6	8	0	1	1	0	0	1	1	4	1	3	1	3	1	1	4	3	1	5	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:65006865T>C	uc002eoi.2	-	9	1766	c.1332A>G	c.(1330-1332)AAA>AAG	p.K444K	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Silent_p.K444K|CDH11_uc010vin.1_Silent_p.K318K	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	444	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TATCCAGAGGTTTTGTAGTTT	0.403			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			16	42					0	0	0	0	C	65006865	C	C	65006865	2	2	276	1	0	0	0	0	0	0	0	1	3112	1722	60	5		5	CDH11	16	65006865	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	3147792	65006865	25347888	1580	51469											
DYNC1LI2	1783	broad.mit.edu	37	chr16	66768138	66768138	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacactgaaggcagaacctcCgcaggtgtgactggataaag	13	7	12	9	1	0	3	0	2	0	1	1	4	1	4	2	3	2	2	2	3	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:66768138C>T	uc002eqb.1	-	6	807	c.776G>A	c.(775-777)CGG>CAG	p.R259Q	DYNC1LI2_uc010vis.1_Missense_Mutation_p.R182Q|DYNC1LI2_uc010vit.1_Missense_Mutation_p.R259Q|DYNC1LI2_uc010viu.1_Missense_Mutation_p.R220Q	NM_006141	NP_006132	O43237	DC1L2_HUMAN	dynein, cytoplasmic, light intermediate	259					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|skin(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		GCAGAACCTCCGCAGGTGTGA	0.527													14	55					0	0	0	0	T	66768138	T	T	66768138	3	4	276	1	0	0	0	0	1	0	0	0	4867	652	23	1	734	1	DYNC1LI2	16	66768138	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1761273	66768138	23586615	1581	51470											
KCTD19	146212	broad.mit.edu	37	chr16	67328009	67328009	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggacctgaccaggtttccCttagccttgttccatggagt	6	14	10	11	0	0	1	0	1	0	0	2	3	2	3	5	3	1	2	5	3	1	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:67328009C>T	uc002esu.2	-	12	1707	c.1656G>A	c.(1654-1656)AAG>AAA	p.K552K	KCTD19_uc002est.2_Silent_p.K324K|KCTD19_uc010vjj.1_Silent_p.K295K	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	552						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CCAGGTTTCCCTTAGCCTTGT	0.562													43	196					0	0	0	0	T	67328009	T	T	67328009	2	4	276	1	0	0	0	0	0	0	0	1	8145	680	24	4		4	KCTD19	16	67328009	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	559871	67328009	23026744	1582	51471											
RLTPR	146206	broad.mit.edu	37	chr16	67690200	67690200	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgcacccactctgtgtctgCtggtgagtgagggccactgt	5	10	13	13	1	2	2	0	2	2	0	2	2	2	2	3	2	1	2	3	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:67690200C>T	uc002etn.2	+	34	3932	c.3812C>T	c.(3811-3813)GCT>GTT	p.A1271V	RLTPR_uc010vjr.1_Missense_Mutation_p.A1235V	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	1271										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		TCTGTGTCTGCTGGTGAGTGA	0.587													23	96					0	0	0	0	T	67690200	T	T	67690200	3	4	276	1	0	0	0	0	1	0	0	0	13459	797	28	4	3946	4	RLTPR	16	67690200	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	362191	67690200	22664553	1583	51472											
ACD	65057	broad.mit.edu	37	chr16	67694198	67694198	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccccgcctttcctcggaaGaggaagctccttcgctgggc	5	8	13	15	3	0	1	0	0	0	1	4	3	2	3	5	4	1	2	5	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:67694198G>A	uc002etq.3	-	1	521	c.184C>T	c.(184-186)CTT>TTT	p.L62F	ACD_uc002etp.3_Missense_Mutation_p.L62F|ACD_uc002etr.3_Missense_Mutation_p.L62F|ACD_uc010vjt.1_Missense_Mutation_p.L52F|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	62					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		TTCCTCGGAAGAGGAAGCTCC	0.736													7	35					0	0	0	0	A	67694198	A	A	67694198	3	1	276	1	0	0	0	0	1	0	0	0	135	942	33	2	1498	2	ACD	16	67694198	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3998	67694198	22660555	1584	51473											
C16orf86	388284	broad.mit.edu	37	chr16	67701384	67701384	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaggccccaggcccgtggtCtccattgtgaggccccgtca	6	7	13	15	2	2	2	1	1	1	1	3	2	2	2	6	4	0	0	6	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:67701384C>T	uc002ety.2	+	2	445	c.288C>T	c.(286-288)GTC>GTT	p.V96V	C16orf48_uc002etv.1_5'Flank|C16orf48_uc002etw.1_5'Flank|C16orf48_uc010cem.1_5'Flank|C16orf86_uc002etx.1_5'UTR|C16orf86_uc002etz.2_RNA	NM_001012984	NP_001013002	Q6ZW13	CP086_HUMAN	hypothetical protein LOC388284	96											0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		GGCCCGTGGTCTCCATTGTGA	0.677													3	20					0	0	0	0	T	67701384	T	T	67701384	2	4	276	1	0	0	0	0	0	0	0	1	1845	900	32	2		2	C16orf86	16	67701384	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	7186	67701384	22653369	1585	51474											
RANBP10	57610	broad.mit.edu	37	chr16	67763288	67763288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggaagaggacgaggaggagGaggaggacgaggatgaggag	14	1	24	2	2	0	2	0	1	0	1	0	13	0	11	0	9	0	0	0	9	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:67763288G>A	uc002eud.2	-	10	1363	c.1247C>T	c.(1246-1248)TCC>TTC	p.S416F	RANBP10_uc010ceo.2_Missense_Mutation_p.S187F|RANBP10_uc010vju.1_Missense_Mutation_p.S360F|RANBP10_uc010vjv.1_Missense_Mutation_p.S299F|RANBP10_uc010vjw.1_Missense_Mutation_p.S77F	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	416	Ser-rich.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		cgaggaggaggaggaggacga	0.413													22	64					0	0	0	0	A	67763288	A	A	67763288	3	1	276	1	0	0	0	0	1	0	0	0	13091	1174	41	2	635	2	RANBP10	16	67763288	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	61904	67763288	22591465	1586	51475											
MARVELD3	91862	broad.mit.edu	37	chr16	71674608	71674609	+	Missense_Mutation	DNP	CC	TT	TT																															gaagtggctcctcacggaggCcgccttcagcctcctagcgg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:71674608_71674609CC>TT	uc002fau.2	+	3	974_975	c.911_912CC>TT	c.(910-912)GCC>GTT	p.A304V	PHLPP2_uc002fav.2_RNA|MARVELD3_uc010cge.2_3'UTR	NM_001017967	NP_001017967	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane				skin(1)	1		Ovarian(137;0.125)				CTCACGGAGGCCGCCTTCAGCC	0.559													21	32					0	0	0	0	TT	71674609	TT	TT	71674608	3	4	276	1	0	0	0	0	1	0	0	0	9372	739	26	4	1536	4	MARVELD3	16	71674608	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	3911320	71674608	18680145	1587	51476											
AP1G1	164	broad.mit.edu	37	chr16	71784220	71784220	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attggggactgcatcatcacGaacataacttcctgcctaaa	13	10	7	11	1	2	0	2	0	0	0	3	2	3	1	2	2	4	1	2	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:71784220G>A	uc010cgg.2	-	14	1614	c.1300C>T	c.(1300-1302)CGT>TGT	p.R434C	AP1G1_uc002fba.2_Missense_Mutation_p.R437C|AP1G1_uc002fbb.2_Missense_Mutation_p.R457C	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	434					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				GCATCATCACGAACATAACTT	0.373													12	99					0	0	0	0	A	71784220	A	A	71784220	3	1	276	1	0	0	0	0	1	0	0	0	732	1058	37	1	1208	1	AP1G1	16	71784220	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	109612	71784220	18570533	1588	51477											
BCAR1	9564	broad.mit.edu	37	chr16	75301841	75301841	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggatccttgggtgtgggcCtgggggcagccagaggagcc	6	6	20	9	0	0	1	0	0	0	1	1	3	1	3	4	6	2	1	4	6	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:75301841C>T	uc002fdx.2	-	1	111	c.38G>A	c.(37-39)AGG>AAG	p.R13K	BCAR1_uc010vnb.1_5'Flank|BCAR1_uc002fdw.2_5'Flank|BCAR1_uc010vnc.1_5'Flank|BCAR1_uc010vnd.1_5'Flank	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGGTGTGGGCCTGGGGGCAGC	0.617													3	15					0	0	0	0	T	75301841	T	T	75301841	3	4	276	1	0	0	0	0	1	0	0	0	1350	681	24	4	2999	4	BCAR1	16	75301841	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3517621	75301841	15052912	1589	51478											
VAT1L	57687	broad.mit.edu	37	chr16	77910306	77910306	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacatcgttttggattgcctCtgtggggacaacactggaaa	10	11	12	8	1	1	0	0	0	1	0	2	4	1	3	1	4	2	1	1	4	2	3	rs150412236	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:77910306C>T	uc002ffg.1	+	5	859	c.762C>T	c.(760-762)CTC>CTT	p.L254L		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	254							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						TGGATTGCCTCTGTGGGGACA	0.483													27	121					0	0	0	0	T	77910306	T	T	77910306	2	4	276	1	0	0	0	0	0	0	0	1	17198	900	32	2		2	VAT1L	16	77910306	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2608465	77910306	12444447	1590	51479											
VAT1L	57687	broad.mit.edu	37	chr16	77918599	77918599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aaatctgctcttcaaacaagGccgggcgggcctcattcggg	9	8	12	12	3	4	0	2	0	2	0	5	0	4	0	2	4	2	1	2	4	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:77918599G>A	uc002ffg.1	+	7	1074	c.977G>A	c.(976-978)GGC>GAC	p.G326D		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	326							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						TTCAAACAAGGCCGGGCGGGC	0.532													10	29					0	0	0	0	A	77918599	A	A	77918599	3	1	276	1	0	0	0	0	1	0	0	0	17198	1203	42	4	1003	4	VAT1L	16	77918599	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	8293	77918599	12436154	1591	51480											
VAT1L	57687	broad.mit.edu	37	chr16	77918680	77918680	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gatcaagcctgtggtggactCcttgtgggctctggaggagg	6	10	17	8	0	2	0	1	0	1	0	3	4	3	3	2	6	1	1	2	6	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:77918680C>T	uc002ffg.1	+	7	1155	c.1058C>T	c.(1057-1059)TCC>TTC	p.S353F		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	353							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						GTGGTGGACTCCTTGTGGGCT	0.483													3	19					0	0	0	0	T	77918680	T	T	77918680	3	4	276	1	0	0	0	0	1	0	0	0	17198	855	30	2	1084	2	VAT1L	16	77918680	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	81	77918680	12436073	1592	51481											
WWOX	51741	broad.mit.edu	37	chr16	78458951	78458951	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtctcctcagagtcccatCggtgggtttgaattgcatat	7	14	11	9	1	2	2	1	1	1	1	5	2	3	2	2	3	1	2	2	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:78458951C>T	uc002ffk.2	+	7	915	c.790C>T	c.(790-792)CGA>TGA	p.R264*	WWOX_uc010vnk.1_Nonsense_Mutation_p.R151*|WWOX_uc002ffl.2_Intron|WWOX_uc010che.2_Intron	NM_016373	NP_057457	Q9NZC7	WWOX_HUMAN	WW domain-containing oxidoreductase isoform 1	264	Interaction with MAPT (By similarity).|Mediates targeting to the mitochondria (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity				0		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		AGAGTCCCATCGGTGGGTTTG	0.473													40	81					0	0	0	0	T	78458951	T	T	78458951	4	4	276	1	0	0	0	0	0	1	0	0	17482	898	31	1	878	1	WWOX	16	78458951	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	540271	78458951	11895802	1593	51482											
CDYL2	124359	broad.mit.edu	37	chr16	80646545	80646545	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcgcgacgcccaggatctggGggaaggtgtaggaggagcag	9	4	20	8	3	1	0	0	0	1	0	1	5	1	4	1	6	1	2	1	6	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:80646545G>A	uc002ffs.2	-	5	1301	c.1196C>T	c.(1195-1197)CCC>CTC	p.P399L		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	399						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						CAGGATCTGGGGGAAGGTGTA	0.632													18	102					0	0	0	0	A	80646545	A	A	80646545	3	1	276	1	0	0	0	0	1	0	0	0	3201	1232	43	4	336	4	CDYL2	16	80646545	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2187594	80646545	9708208	1594	51483											
CENPN	55839	broad.mit.edu	37	chr16	81045703	81045703	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctgtagttcagcacttgatCcatctgtgtgaggtaacagt	9	14	10	8	0	3	2	1	2	2	0	4	2	4	2	1	1	2	4	1	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:81045703C>T	uc002ffx.2	+	2	949	c.159C>T	c.(157-159)ATC>ATT	p.I53I	CENPN_uc002ffw.3_Silent_p.I53I|CENPN_uc010vnl.1_Silent_p.I53I|CENPN_uc010vnm.1_Silent_p.I53I|CENPN_uc002ffy.3_Silent_p.I53I	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	53					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						AGCACTTGATCCATCTGTGTG	0.403													8	57					0	0	0	0	T	81045703	T	T	81045703	2	4	276	1	0	0	0	0	0	0	0	1	3253	845	30	2		2	CENPN	16	81045703	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	399158	81045703	9309050	1595	51484											
PKD1L2	114780	broad.mit.edu	37	chr16	81134881	81134881	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatctacgatctccccttcCtccgacagctgcaagagaaa	13	8	6	14	2	2	1	0	0	2	1	5	4	4	1	4	0	3	2	4	0	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:81134881C>T	uc002fgh.1	-	45	7227	c.7227G>A	c.(7225-7227)GAG>GAA	p.E2409E	PKD1L2_uc002fgf.1_Silent_p.E209E|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2409	Extracellular (Potential).|Interaction with GNAS and GNAI1.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TCTCCCCTTCCTCCGACAGCT	0.458													9	40					0	0	0	0	T	81134881	T	T	81134881	2	4	276	1	0	0	0	0	0	0	0	1	12020	680	24	4		4	PKD1L2	16	81134881	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	89178	81134881	9219872	1596	51485											
CMIP	80790	broad.mit.edu	37	chr16	81725433	81725433	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtttgcttcaacccattcCattccccaaagagtaagtcc	11	11	5	14	0	1	1	1	0	0	1	4	1	4	1	5	0	2	3	5	0	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:81725433C>T	uc002fgp.2	+	11	1514	c.1442C>T	c.(1441-1443)CCA>CTA	p.P481L	CMIP_uc002fgq.1_Missense_Mutation_p.P387L|CMIP_uc010vnq.1_Missense_Mutation_p.P294L|CMIP_uc002fgr.1_Missense_Mutation_p.P328L|CMIP_uc010vnr.1_5'Flank	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	447						cytoplasm|nucleus					0						CAACCCATTCCATTCCCCAAA	0.547													12	24					0	0	0	0	T	81725433	T	T	81725433	3	4	276	1	0	0	0	0	1	0	0	0	3593	594	21	4	1506	4	CMIP	16	81725433	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	590552	81725433	8629320	1597	51486											
KCNG4	93107	broad.mit.edu	37	chr16	84256431	84256431	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctcggcctctcgccgtcctCcgggggctcctcagacaccg	3	7	12	19	5	2	1	1	0	1	1	7	1	5	1	6	3	0	2	6	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:84256431C>T	uc010voc.1	-	3	1073	c.952G>A	c.(952-954)GAG>AAG	p.E318K		NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	318						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						TCGCCGTCCTCCGGGGGCTCC	0.647													3	18					0	0	0	0	T	84256431	T	T	84256431	3	4	276	1	0	0	0	0	1	0	0	0	8069	864	30	2	609	2	KCNG4	16	84256431	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2530998	84256431	6098322	1598	51487											
KCNG4	93107	broad.mit.edu	37	chr16	84256561	84256561	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaccgcaggcagaactccagGgagaaccaggccacgcagat	14	2	12	13	2	0	3	0	0	0	3	1	4	1	3	4	3	3	3	4	3	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:84256561G>A	uc010voc.1	-	3	943	c.822C>T	c.(820-822)TCC>TCT	p.S274S		NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	274	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						AGAACTCCAGGGAGAACCAGG	0.567													3	26					0	0	0	0	A	84256561	A	A	84256561	2	1	276	1	0	0	0	0	0	0	0	1	8069	1219	43	4		4	KCNG4	16	84256561	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	130	84256561	6098192	1599	51488											
IRF8	3394	broad.mit.edu	37	chr16	85953824	85953824	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgcgctccaaactcattctCgtgcaggtaagtatgggcag	9	11	11	10	2	2	0	1	0	1	0	4	0	3	0	1	2	3	5	1	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:85953824C>T	uc002fjh.2	+	8	1155	c.1098C>T	c.(1096-1098)CTC>CTT	p.L366L	IRF8_uc010chp.2_RNA	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	366					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				AACTCATTCTCGTGCAGGTAA	0.348													8	17					0	0	0	0	T	85953824	T	T	85953824	2	4	276	1	0	0	0	0	0	0	0	1	7875	871	31	1		1	IRF8	16	85953824	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1697263	85953824	4400929	1600	51489											
BANP	54971	broad.mit.edu	37	chr16	88061239	88061239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcggagaacgcccaactcgtCctcctactgcccttcaggta	8	8	9	16	3	1	1	1	0	0	1	4	2	3	1	4	2	4	1	4	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:88061239C>T	uc002fkr.2	+	8	1243	c.1019C>T	c.(1018-1020)TCC>TTC	p.S340F	BANP_uc002fkp.2_Missense_Mutation_p.S310F|BANP_uc002fkq.2_Missense_Mutation_p.S310F|BANP_uc010vow.1_Missense_Mutation_p.S348F|BANP_uc002fks.3_Missense_Mutation_p.S309F|BANP_uc002fko.1_Missense_Mutation_p.S246F|BANP_uc010vov.1_Missense_Mutation_p.S315F	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	341	Necessary and sufficient for TP53 activation (By similarity).|Interaction with CUX1 and HDAC1 (By similarity).				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		CCCAACTCGTCCTCCTACTGC	0.697													6	71					0	0	0	0	T	88061239	T	T	88061239	3	4	276	1	0	0	0	0	1	0	0	0	1312	855	30	2	1090	2	BANP	16	88061239	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2107415	88061239	2293514	1601	51490											
ANKRD11	29123	broad.mit.edu	37	chr16	89341587	89341587	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caggggctccgccagggaggGagggggtgcgatctacaggc	7	4	20	10	2	1	0	0	0	1	0	2	3	2	2	2	7	2	1	2	7	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:89341587G>A	uc002fmx.1	-	10	7944	c.7483C>T	c.(7483-7485)CCC>TCC	p.P2495S	ANKRD11_uc002fmy.1_Missense_Mutation_p.P2495S	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2495						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCCAGGGAGGGAGGGGGTGCG	0.637													9	15					0	0	0	0	A	89341587	A	A	89341587	3	1	276	1	0	0	0	0	1	0	0	0	639	1174	41	2	524	2	ANKRD11	16	89341587	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1280348	89341587	1013166	1602	51491											
SPATA2L	124044	broad.mit.edu	37	chr16	89764657	89764657	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atcttctggaagctcttcagGaggaggtcgtctgagagcac	9	10	13	9	1	5	1	1	1	4	1	6	5	5	4	0	4	2	2	0	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr16:89764657G>A	uc002foj.2	-	3	425	c.360C>T	c.(358-360)CTC>CTT	p.L120L	SPATA2L_uc002fok.2_Silent_p.L120L	NM_152339	NP_689552	Q8IUW3	SPA2L_HUMAN	spermatogenesis associated 2-like	120											0		Lung NSC(15;0.00043)|all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		AGCTCTTCAGGAGGAGGTCGT	0.647													30	211					0	0	0	0	A	89764657	A	A	89764657	2	1	276	1	0	0	0	0	0	0	0	1	15075	1161	41	2		2	SPATA2L	16	89764657	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	423070	89764657	590096	1603	51492											
RNMTL1	55178	broad.mit.edu	37	chr17	685749	685749	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agtgaaagtggtgtttccttCcggagaggtggtggaacaga	10	10	16	5	1	0	3	0	1	0	2	2	5	2	4	2	5	1	1	2	5	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:685749C>T	uc002frw.2	+	1	237	c.131C>T	c.(130-132)TCC>TTC	p.S44F	GLOD4_uc002fru.2_5'Flank|GLOD4_uc010vqc.1_5'Flank|GLOD4_uc002frv.2_5'Flank	NM_018146	NP_060616	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	44					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		GTGTTTCCTTCCGGAGAGGTG	0.657													7	43					0	0	0	0	T	685749	T	T	685749	3	4	276	1	0	0	0	0	1	0	0	0	13572	855	30	2	133	2	RNMTL1	17	685749	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08		685749	80509461	1604	51493											
ABR	29	broad.mit.edu	37	chr17	915171	915171	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctcctcgatacccctcttCtccacctcctccacacactg	7	10	2	22	1	2	0	0	0	2	0	7	1	5	0	8	0	1	0	8	0	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:915171C>T	uc002fsd.2	-	19	2126	c.2016G>A	c.(2014-2016)GAG>GAA	p.E672E	ABR_uc002fse.2_Silent_p.E626E|ABR_uc010vqf.1_Silent_p.E123E|ABR_uc010vqg.1_Silent_p.E454E|ABR_uc002fsg.2_Silent_p.E635E|ABR_uc002fsh.1_Silent_p.E280E|ABR_uc002fsf.2_Silent_p.E209E	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	672	Rho-GAP.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		TACCCCTCTTCTCCACCTCCT	0.652													16	49					0	0	0	0	T	915171	T	T	915171	2	4	276	1	0	0	0	0	0	0	0	1	99	912	32	2		2	ABR	17	915171	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	229422	915171	80280039	1605	51494											
TUSC5	286753	broad.mit.edu	37	chr17	1183397	1183397	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atactcctcaccaaggcagaGaacaaggatgacaagaccct	16	5	8	12	0	1	3	1	1	0	2	2	5	2	4	3	2	2	1	3	2	5	1	rs75025906	by1000genomes	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:1183397G>A	uc002fsi.1	+	1	441	c.102G>A	c.(100-102)GAG>GAA	p.E34E		NM_172367	NP_758955	Q8IXB3	TUSC5_HUMAN	LOST1	34			E -> D.		response to biotic stimulus	integral to membrane				skin(2)	2				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCAAGGCAGAGAACAAGGATG	0.607													18	70					0	0	0	0	A	1183397	A	A	1183397	2	1	276	1	0	0	0	0	0	0	0	1	16847	933	33	2		2	TUSC5	17	1183397	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	268226	1183397	80011813	1606	51495											
PRPF8	10594	broad.mit.edu	37	chr17	1584266	1584266	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagattgttgtacaagtaagGaaaagcaatcttgtactcag	16	11	9	5	0	2	1	1	0	1	1	2	2	2	2	0	1	3	5	0	1	8	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:1584266G>A	uc002fte.2	-	7	1063	c.949C>T	c.(949-951)CCT>TCT	p.P317S		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	317						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TACAAGTAAGGAAAAGCAATC	0.443													47	212					0	0	0	0	A	1584266	A	A	1584266	3	1	276	1	0	0	0	0	1	0	0	0	12637	1174	41	2	6206	2	PRPF8	17	1584266	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	400869	1584266	79610944	1607	51496											
PRPF8	10594	broad.mit.edu	37	chr17	1584903	1584903	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcatccaccaagtctgtcagGagctgattagccaggcggta	10	9	11	11	1	3	1	2	1	1	0	4	2	4	2	3	3	2	2	3	3	3	2	rs145114613		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:1584903G>A	uc002fte.2	-	6	849	c.735C>T	c.(733-735)CTC>CTT	p.L245L		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	245						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		AGTCTGTCAGGAGCTGATTAG	0.473													42	149					0	0	0	0	A	1584903	A	A	1584903	2	1	276	1	0	0	0	0	0	0	0	1	12637	1161	41	2		2	PRPF8	17	1584903	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	637	1584903	79610307	1608	51497											
SERPINF1	5176	broad.mit.edu	37	chr17	1674431	1674431	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gctccttgacacggtcactgCcccccagaagaacctcaaga	11	6	8	16	1	2	4	2	1	0	3	3	4	3	4	5	1	2	1	5	1	3	1	rs148005190		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:1674431C>T	uc002ftl.2	+	4	549	c.392C>T	c.(391-393)GCC>GTC	p.A131V	SERPINF1_uc010cjw.2_Intron	NM_002615	NP_002606	P36955	PEDF_HUMAN	serine (or cysteine) proteinase inhibitor, clade	131					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			ovary(1)	1						ACGGTCACTGCCCCCCAGAAG	0.547													11	43					0	0	0	0	T	1674431	T	T	1674431	3	4	276	1	0	0	0	0	1	0	0	0	14179	739	26	4	402	4	SERPINF1	17	1674431	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	89528	1674431	79520779	1609	51498											
METT10D	79066	broad.mit.edu	37	chr17	2323366	2323366	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acccagtgcatctccactaaGgcatcgtccacctccttctt	8	11	5	17	1	2	0	0	0	2	0	6	0	4	0	5	1	1	2	5	1	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:2323366G>A	uc002fut.2	-	10	1735	c.1587C>T	c.(1585-1587)GCC>GCT	p.A529A	METT10D_uc002fuu.3_RNA|METT10D_uc010cka.2_RNA|METT10D_uc002fuv.2_Intron|METT10D_uc010vqx.1_RNA|METT10D_uc010vqy.1_Silent_p.A311A	NM_024086	NP_076991	Q86W50	MET16_HUMAN	methyltransferase 10 domain containing	529							methyltransferase activity				0						TCTCCACTAAGGCATCGTCCA	0.502													9	52					0	0	0	0	A	2323366	A	A	2323366	2	1	276	1	0	0	0	0	0	0	0	1	9543	987	35	4		4	METT10D	17	2323366	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	648935	2323366	78871844	1610	51499											
OR1A1	8383	broad.mit.edu	37	chr17	3118956	3118956	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctacactggaattcatcctCctgggagttactggtcagca	9	12	9	11	0	3	0	2	0	1	0	5	2	5	2	2	3	3	2	2	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:3118956C>T	uc010vrc.1	+	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AATTCATCCTCCTGGGAGTTA	0.418													17	67					0	0	0	0	T	3118956	T	T	3118956	2	4	276	1	0	0	0	0	0	0	0	1	11003	842	30	2		2	OR1A1	17	3118956	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	795590	3118956	78076254	1611	51500											
ZZEF1	23140	broad.mit.edu	37	chr17	3980240	3980240	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccactgtactgtgagaaaagGgattccaaaatcgctctcat	13	10	8	10	1	1	1	1	1	1	1	4	3	2	2	2	1	1	2	2	1	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:3980240G>A	uc002fxe.2	-	20	3097	c.3033C>T	c.(3031-3033)TCC>TCT	p.S1011S	ZZEF1_uc002fxk.1_Silent_p.S1012S	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1011							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTGAGAAAAGGGATTCCAAAA	0.368													10	44					0	0	0	0	A	3980240	A	A	3980240	2	1	276	1	0	0	0	0	0	0	0	1	18322	1219	43	4		4	ZZEF1	17	3980240	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	861284	3980240	77214970	1612	51501											
ARRB2	409	broad.mit.edu	37	chr17	4620534	4620535	+	Missense_Mutation	DNP	CC	TT	TT																															accccagaatcttccatgctCcgtcacactgcagccaggcc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:4620534_4620535CC>TT	uc002fyj.2	+	6	608_609	c.380_381CC>TT	c.(379-381)TCC>TTT	p.S127F	ARRB2_uc002fyk.2_Missense_Mutation_p.S112F|ARRB2_uc002fyl.2_Missense_Mutation_p.S127F|ARRB2_uc010vsg.1_Missense_Mutation_p.S148F|ARRB2_uc002fym.2_Missense_Mutation_p.S112F|ARRB2_uc002fyn.2_5'UTR|ARRB2_uc010ckq.2_5'UTR|ARRB2_uc002fyo.2_5'UTR	NM_004313	NP_004304	P32121	ARRB2_HUMAN	arrestin, beta 2 isoform 1	127					cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding				0						CTTCCATGCTCCGTCACACTGC	0.569													13	87					0	0	0	0	TT	4620535	TT	TT	4620534	3	4	276	1	0	0	0	0	1	0	0	0	983	855	30	2	402	2	ARRB2	17	4620534	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	640294	4620534	76574676	1613	51502											
USP6	9098	broad.mit.edu	37	chr17	5042964	5042964	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctggcaggctgaacactgcgGagagggtgaggttggctttc	7	9	17	8	1	0	3	0	2	0	1	1	4	0	3	0	6	2	4	0	6	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:5042964G>A	uc002gau.1	+	22	3723	c.1493G>A	c.(1492-1494)GGA>GAA	p.G498E	USP6_uc002gav.1_Missense_Mutation_p.G498E|USP6_uc010ckz.1_Missense_Mutation_p.G181E|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	498					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						GAACACTGCGGAGAGGGTGAG	0.602			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								7	56					0	0	0	0	A	5042964	A	A	5042964	3	1	276	1	0	0	0	0	1	0	0	0	17154	1174	41	2	1543	2	USP6	17	5042964	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	422430	5042964	76152246	1614	51503											
RPAIN	84268	broad.mit.edu	37	chr17	5323605	5323605	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccgccttggaaagaggctttCcggcaggtgggtatggggtt	6	10	17	8	2	0	1	0	0	0	1	1	2	1	2	3	7	0	4	3	7	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:5323605C>T	uc002gbq.2	+	1	645	c.75C>T	c.(73-75)TTC>TTT	p.F25F	NUP88_uc002gbo.1_5'Flank|NUP88_uc010vsx.1_5'Flank|NUP88_uc010cle.1_5'Flank|NUP88_uc010vsy.1_5'Flank|RPAIN_uc010vsz.1_Silent_p.F25F|RPAIN_uc002gbp.1_Missense_Mutation_p.P79S|RPAIN_uc010vta.1_Silent_p.F25F|RPAIN_uc010vtb.1_Silent_p.F25F|RPAIN_uc002gbs.2_Missense_Mutation_p.P79S|RPAIN_uc002gbt.2_Silent_p.F25F|RPAIN_uc002gbu.2_Missense_Mutation_p.P79S|RPAIN_uc002gbv.2_RNA|RPAIN_uc002gbr.2_RNA|RPAIN_uc002gbw.2_Silent_p.F25F	NM_001033002	NP_001028174	Q86UA6	RIP_HUMAN	RPA interacting protein isoform b	25					DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|cytoplasm|nucleolus|PML body|PML body	metal ion binding|protein complex binding				0						AAGAGGCTTTCCGGCAGGTGG	0.632													7	34					0	0	0	0	T	5323605	T	T	5323605	2	4	276	1	0	0	0	0	0	0	0	1	13605	854	30	2		2	RPAIN	17	5323605	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	280641	5323605	75871605	1615	51504											
RPAIN	84268	broad.mit.edu	37	chr17	5329615	5329615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtggcctgtccatcccatCtcatgtgagtgttccacaca	7	12	9	13	0	1	1	1	1	1	0	5	1	4	1	4	1	0	1	4	1	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:5329615C>T	uc002gbq.2	+	5	1055	c.485C>T	c.(484-486)TCT>TTT	p.S162F	RPAIN_uc010vsz.1_Missense_Mutation_p.S162F|RPAIN_uc002gbp.1_Missense_Mutation_p.S178F|RPAIN_uc010vta.1_Intron|RPAIN_uc010vtb.1_Intron|RPAIN_uc002gbs.2_Missense_Mutation_p.S178F|RPAIN_uc002gbt.2_Missense_Mutation_p.S162F|RPAIN_uc002gbu.2_Missense_Mutation_p.S178F|RPAIN_uc002gbv.2_Intron|RPAIN_uc002gbr.2_Intron|RPAIN_uc002gbw.2_Intron|RPAIN_uc002gbx.1_5'Flank	NM_001033002	NP_001028174	Q86UA6	RIP_HUMAN	RPA interacting protein isoform b	162	RIP-type.				DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|cytoplasm|nucleolus|PML body|PML body	metal ion binding|protein complex binding				0						TCCATCCCATCTCATGTGAGT	0.448													23	91					0	0	0	0	T	5329615	T	T	5329615	3	4	276	1	0	0	0	0	1	0	0	0	13605	913	32	2	503	2	RPAIN	17	5329615	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6010	5329615	75865595	1616	51505											
MIS12	79003	broad.mit.edu	37	chr17	5392534	5392534	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaagattttcagcatctcCagaaagaaattgaacagtta	17	10	8	6	0	2	4	1	1	1	3	3	5	2	5	1	1	2	2	1	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:5392534C>T	uc002gcd.2	+	2	681	c.352C>T	c.(352-354)CAG>TAG	p.Q118*	MIS12_uc002gce.2_Nonsense_Mutation_p.Q118*	NM_024039	NP_076944	Q9H081	MIS12_HUMAN	MIS12 homolog	118	Potential.				cell division|chromosome segregation|kinetochore assembly|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding				0						TCAGCATCTCCAGAAAGAAAT	0.378													16	49					0	0	0	0	T	5392534	T	T	5392534	4	4	276	1	0	0	0	0	0	1	0	0	9647	595	21	4	354	4	MIS12	17	5392534	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	62919	5392534	75802676	1617	51506											
PITPNM3	83394	broad.mit.edu	37	chr17	6364730	6364730	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggaagatggccttctgcCgcagcgggtcatgcaccagc	8	6	14	13	2	2	1	1	0	1	1	2	2	2	2	3	3	4	3	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:6364730C>T	uc002gdd.3	-	18	2604	c.2453G>A	c.(2452-2454)CGG>CAG	p.R818Q	PITPNM3_uc010cln.2_Missense_Mutation_p.R782Q|PITPNM3_uc010clm.2_Missense_Mutation_p.R301Q|PITPNM3_uc002gdc.3_Missense_Mutation_p.R409Q	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	818					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		GGCCTTCTGCCGCAGCGGGTC	0.632													42	35					0	0	0	0	T	6364730	T	T	6364730	3	4	276	1	0	0	0	0	1	0	0	0	12007	652	23	1	483	1	PITPNM3	17	6364730	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	972196	6364730	74830480	1618	51507											
SLC13A5	284111	broad.mit.edu	37	chr17	6594098	6594098	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccactgtcaggttacttacCatggaggcaaagatgggcag	11	8	12	10	0	1	1	1	0	0	1	1	2	1	2	2	4	2	3	2	4	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:6594098C>T	uc002gdj.2	-	10	1525	c.1437G>A	c.(1435-1437)ATG>ATA	p.M479I	SLC13A5_uc010vtf.1_Missense_Mutation_p.M479I|SLC13A5_uc010clq.2_Missense_Mutation_p.M436I|SLC13A5_uc002gdk.2_Missense_Mutation_p.M462I	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	479						integral to membrane	citrate transmembrane transporter activity				0						GGTTACTTACCATGGAGGCAA	0.552													27	107					0	0	0	0	T	6594098	T	T	6594098	3	4	276	1	0	0	0	0	1	0	0	0	14460	608	21	4	281	4	SLC13A5	17	6594098	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	229368	6594098	74601112	1619	51508											
ACAP1	9744	broad.mit.edu	37	chr17	7250425	7250425	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccaggggaagggagcctgggGgagtcgggcacgtggtggcc	6	4	22	9	2	0	0	0	0	0	0	1	3	0	3	3	8	1	1	3	8	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:7250425G>A	uc002ggd.2	+	14	1413	c.1207G>A	c.(1207-1209)GGA>AGA	p.G403R		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	403					intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						GGAGCCTGGGGGAGTCGGGCA	0.677													20	16					0	0	0	0	A	7250425	A	A	7250425	3	1	276	1	0	0	0	0	1	0	0	0	118	1233	43	4	1261	4	ACAP1	17	7250425	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	656327	7250425	73944785	1620	51509											
DNAH2	146754	broad.mit.edu	37	chr17	7721717	7721717	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caccaccaagctctccaaccCccactacagcccagagacct	12	4	4	21	0	1	1	0	0	1	1	2	2	1	1	7	0	4	1	7	0	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:7721717C>T	uc002giu.1	+	68	10489	c.10475C>T	c.(10474-10476)CCC>CTC	p.P3492L	DNAH2_uc010cnm.1_Missense_Mutation_p.P430L	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3492	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTCTCCAACCCCCACTACAGC	0.522													28	176					0	0	0	0	T	7721717	T	T	7721717	3	4	276	1	0	0	0	0	1	0	0	0	4624	623	22	4	10745	4	DNAH2	17	7721717	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	471292	7721717	73473493	1621	51510											
CNTROB	116840	broad.mit.edu	37	chr17	7849045	7849046	+	Splice_Site	DNP	GG	AA	AA																															ttctgcctctctcctggtcaGgctcctcctgctggaccctc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:7849045_7849046GG>AA	uc002gjq.2	+	14	2654	c.1735_splice	c.e14-1	p.A579_splice	CNTROB_uc002gjp.2_Splice_Site_p.A579_splice|CNTROB_uc002gjr.2_Splice_Site_p.A481_splice	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein						centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				CTCCTGGTCAGGCTCCTCCTGC	0.505													22	51					0	0	0	0	AA	7849046	AA	AA	7849045	5	1	276	1	0	0	0	0	0	0	1	0	3666	1014	35	4	1784	4	CNTROB	17	7849045	Splice_Site	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	127328	7849045	73346165	1622	51511											
GUCY2D	3000	broad.mit.edu	37	chr17	7917309	7917309	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtgctgggcagagcagcCggaacttcggccctccatgg	7	6	15	13	2	0	1	0	0	0	1	2	2	1	2	3	4	4	4	3	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:7917309C>T	uc002gjt.2	+	12	2449	c.2375C>T	c.(2374-2376)CCG>CTG	p.P792L		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	792	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				GCAGAGCAGCCGGAACTTCGG	0.637													9	81					0	0	0	0	T	7917309	T	T	7917309	3	4	276	1	0	0	0	0	1	0	0	0	6936	652	23	1	2417	1	GUCY2D	17	7917309	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	68264	7917309	73277901	1623	51512											
GUCY2D	3000	broad.mit.edu	37	chr17	7918202	7918202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggctgaggccttgaagacgGggacaccagtggagcccgag	9	5	17	10	2	0	3	0	2	0	1	0	6	0	5	3	5	1	1	3	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:7918202G>A	uc002gjt.2	+	14	2676	c.2602G>A	c.(2602-2604)GGG>AGG	p.G868R		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	868	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				CTTGAAGACGGGGACACCAGT	0.597													33	26					0	0	0	0	A	7918202	A	A	7918202	3	1	276	1	0	0	0	0	1	0	0	0	6936	1232	43	4	2652	4	GUCY2D	17	7918202	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	893	7918202	73277008	1624	51513											
PFAS	5198	broad.mit.edu	37	chr17	8161418	8161418	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctccttgggcctccagctcCcagacggccagcggcgtgag	5	6	14	16	3	0	2	0	1	0	1	3	2	3	2	5	3	2	2	5	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:8161418C>T	uc002gkr.2	+	11	1378	c.1237C>T	c.(1237-1239)CCA>TCA	p.P413S	PFAS_uc010vuv.1_5'UTR	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	413					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCTCCAGCTCCCAGACGGCCA	0.622													17	46					0	0	0	0	T	8161418	T	T	8161418	3	4	276	1	0	0	0	0	1	0	0	0	11809	623	22	4	1275	4	PFAS	17	8161418	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	243216	8161418	73033792	1625	51514											
PFAS	5198	broad.mit.edu	37	chr17	8169333	8169333	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcactcaggggctgctgaAaggtgagtgaagacccctgg	10	7	14	10	0	2	4	2	3	0	1	2	4	2	4	2	4	1	2	2	4	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:8169333A>C	uc002gkr.2	+	21	2840	c.2699A>C	c.(2698-2700)AAA>ACA	p.K900T	PFAS_uc010vuv.1_Missense_Mutation_p.K476T|PFAS_uc002gks.2_5'UTR	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	900					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGGCTGCTGAAAGGTGAGTGA	0.612													5	30					0	0	0	0	C	8169333	C	C	8169333	3	2	276	1	0	0	0	0	1	0	0	0	11809	14	1	5	2777	5	PFAS	17	8169333	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	7915	8169333	73025877	1626	51515											
PFAS	5198	broad.mit.edu	37	chr17	8172385	8172385	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagagcagtaccctctgaatCccaatgggtccccagggggc	9	6	12	14	0	1	2	0	1	1	1	3	2	3	2	4	3	2	2	4	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:8172385C>T	uc002gkr.2	+	28	3961	c.3820C>T	c.(3820-3822)CCC>TCC	p.P1274S	PFAS_uc010vuv.1_Missense_Mutation_p.P850S|PFAS_uc002gks.2_3'UTR	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	1274	Glutamine amidotransferase type-1.				'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCCTCTGAATCCCAATGGGTC	0.627													50	29					0	0	0	0	T	8172385	T	T	8172385	3	4	276	1	0	0	0	0	1	0	0	0	11809	855	30	2	3926	2	PFAS	17	8172385	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3052	8172385	73022825	1627	51516											
MYH13	8735	broad.mit.edu	37	chr17	10205018	10205018	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgcgtgttggcctgctcCtcctgcacaggagacagagg	7	8	14	12	1	0	2	0	0	0	2	2	3	2	2	3	3	4	4	3	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:10205018C>T	uc002gmk.1	-	40	5760	c.5670G>A	c.(5668-5670)GAG>GAA	p.E1890E		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1890	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGGCCTGCTCCTCCTGCACAG	0.602													7	44					0	0	0	0	T	10205018	T	T	10205018	2	4	276	1	0	0	0	0	0	0	0	1	10085	680	24	4		4	MYH13	17	10205018	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2032633	10205018	70990192	1628	51517											
MYH13	8735	broad.mit.edu	37	chr17	10206584	10206584	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccaggtcctggagcctaaGgatattcttgtggtcctcct	7	12	10	12	0	1	0	0	0	1	0	4	2	4	2	5	4	1	0	5	4	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:10206584G>A	uc002gmk.1	-	39	5686	c.5596C>T	c.(5596-5598)CTT>TTT	p.L1866F		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1866	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGGAGCCTAAGGATATTCTTG	0.577													35	152					0	0	0	0	A	10206584	A	A	10206584	3	1	276	1	0	0	0	0	1	0	0	0	10085	1000	35	4	232	4	MYH13	17	10206584	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1566	10206584	70988626	1629	51518											
MYH4	4622	broad.mit.edu	37	chr17	10354694	10354694	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgacaactcatttattaagcGttgttgctcttcttcctttg	7	19	6	9	1	3	1	1	1	2	0	4	1	4	1	1	0	3	3	1	0	3	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:10354694G>A	uc002gmn.2	-	28	3925	c.3814C>T	c.(3814-3816)CGC>TGC	p.R1272C	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1272	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TTTATTAAGCGTTGTTGCTCT	0.433													18	70					0	0	0	0	A	10354694	A	A	10354694	3	1	276	1	0	0	0	0	1	0	0	0	10090	1145	40	1	2057	1	MYH4	17	10354694	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	148110	10354694	70840516	1630	51519											
MYH4	4622	broad.mit.edu	37	chr17	10358389	10358389	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccagcaggccagctttgaaGaaaaccttatgaaagaacaa	17	6	8	10	0	0	4	0	2	0	2	0	4	0	4	3	1	4	2	3	1	7	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:10358389G>A	uc002gmn.2	-	21	2415	c.2304C>T	c.(2302-2304)TTC>TTT	p.F768F	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	768	Myosin head-like.|Actin-binding (By similarity).				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CAGCTTTGAAGAAAACCTTAT	0.403													13	71					0	0	0	0	A	10358389	A	A	10358389	2	1	276	1	0	0	0	0	0	0	0	1	10090	933	33	2		2	MYH4	17	10358389	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3695	10358389	70836821	1631	51520											
MYH4	4622	broad.mit.edu	37	chr17	10369997	10369997	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgagcttcaattcgctcCttttcagactttcggaggaa	8	15	8	10	2	3	2	2	1	1	1	6	4	4	4	1	2	1	2	1	2	2	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:10369997C>T	uc002gmn.2	-	3	177	c.66G>A	c.(64-66)AAG>AAA	p.K22K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	22	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CAATTCGCTCCTTTTCAGACT	0.493													27	104					0	0	0	0	T	10369997	T	T	10369997	2	4	276	1	0	0	0	0	0	0	0	1	10090	680	24	4		4	MYH4	17	10369997	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	11608	10369997	70825213	1632	51521											
MYH1	4619	broad.mit.edu	37	chr17	10402027	10402027	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caacctcactgttggccttgGacattgctctctgtagctcg	6	13	9	13	1	2	0	1	0	1	0	4	1	2	1	2	2	3	4	2	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:10402027G>A	uc002gmo.2	-	30	4191	c.4097C>T	c.(4096-4098)TCC>TTC	p.S1366F	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1366	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GTTGGCCTTGGACATTGCTCT	0.572													80	59					0	0	0	0	A	10402027	A	A	10402027	3	1	276	1	0	0	0	0	1	0	0	0	10082	1174	41	2	1766	2	MYH1	17	10402027	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	32030	10402027	70793183	1633	51522											
MYH1	4619	broad.mit.edu	37	chr17	10408289	10408289	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tctgtctctgcacttttgagGaggggtttgatcttgaaata	8	16	11	6	0	3	3	0	3	3	0	4	4	3	4	0	3	1	2	0	3	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:10408289G>T	uc002gmo.2	-	22	2623	c.2529C>A	c.(2527-2529)CTC>CTA	p.L843L	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	843	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CACTTTTGAGGAGGGGTTTGA	0.463													24	92					4.72057e-08	4.81164e-08	1	0	T	10408289	T	T	10408289	2	4	276	1	0	0	0	0	0	0	0	1	10082	1161	41	2		2	MYH1	17	10408289	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6262	10408289	70786921	1634	51523											
MYH2	4620	broad.mit.edu	37	chr17	10432160	10432160	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctgcatgcttcttcctcagGgtggccgctgtggcttcatg	3	14	12	12	1	4	0	2	0	2	0	5	0	5	0	2	3	2	4	2	3	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:10432160G>A	uc010coi.2	-	27	3719	c.3591C>T	c.(3589-3591)ACC>ACT	p.T1197T	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.T1197T|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1197	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCTTCCTCAGGGTGGCCGCTG	0.562													26	120					0	0	0	0	A	10432160	A	A	10432160	2	1	276	1	0	0	0	0	0	0	0	1	10088	1219	43	4		4	MYH2	17	10432160	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	23871	10432160	70763050	1635	51524											
MYH2	4620	broad.mit.edu	37	chr17	10450897	10450897	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atcttgtcatatttgggaggGttcatggggaagacctgatc	9	13	13	6	0	3	2	2	1	1	1	4	4	3	4	1	4	0	1	1	4	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:10450897G>A	uc010coi.2	-	4	371	c.243C>T	c.(241-243)AAC>AAT	p.N81N	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.N81N|MYH2_uc010coj.2_Silent_p.N81N	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	81	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						ATTTGGGAGGGTTCATGGGGA	0.433													103	73					0	0	0	0	A	10450897	A	A	10450897	2	1	276	1	0	0	0	0	0	0	0	1	10088	1252	44	4		4	MYH2	17	10450897	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	18737	10450897	70744313	1636	51525											
RICH2	9912	broad.mit.edu	37	chr17	12847451	12847451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acctcaccatcagcggccggGagatcgccttccccatcgag	8	6	10	17	4	2	1	2	0	0	1	5	3	3	1	6	2	1	0	6	2	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:12847451G>A	uc002gnr.3	+	10	1126	c.799G>A	c.(799-801)GAG>AAG	p.E267K	RICH2_uc010vvk.1_Missense_Mutation_p.E267K|RICH2_uc010vvl.1_Missense_Mutation_p.E267K|RICH2_uc002gns.3_Missense_Mutation_p.E67K|RICH2_uc010vvm.1_Missense_Mutation_p.E267K|RICH2_uc010vvn.1_RNA|RICH2_uc002gnt.1_5'UTR	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	267	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						CAGCGGCCGGGAGATCGCCTT	0.632													5	34					0	0	0	0	A	12847451	A	A	12847451	3	1	276	1	0	0	0	0	1	0	0	0	13422	1175	41	2	837	2	RICH2	17	12847451	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2396554	12847451	68347759	1637	51526											
MPRIP	23164	broad.mit.edu	37	chr17	17062129	17062129	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catggaggtggaccggagccCagggctgcctatgagcgacc	8	5	16	12	2	0	1	0	1	0	0	0	5	0	4	4	5	3	1	4	5	1	1	rs146616345		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:17062129C>T	uc002gqu.1	+	14	1915	c.1859C>T	c.(1858-1860)CCA>CTA	p.P620L	MPRIP_uc002gqv.1_Missense_Mutation_p.P620L|MPRIP_uc002gqw.1_Missense_Mutation_p.P375L	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	620	Interaction with RHOA.					cytoplasm|cytoskeleton	actin binding				0						GACCGGAGCCCAGGGCTGCCT	0.652													33	28					0	0	0	0	T	17062129	T	T	17062129	3	4	276	1	0	0	0	0	1	0	0	0	9796	594	21	4	1913	4	MPRIP	17	17062129	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4214678	17062129	64133081	1638	51527											
FLCN	201163	broad.mit.edu	37	chr17	17116981	17116981	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacgggtcagttccgagaCtccgaggctgtggggctgcg	5	8	18	10	4	1	2	1	1	0	1	3	4	3	2	2	4	1	3	2	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:17116981C>T	uc002gra.3	-	14	2232	c.1728G>A	c.(1726-1728)GAG>GAA	p.E576E	PLD6_uc010cpn.2_Intron	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	576					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						AGTTCCGAGACTCCGAGGCTG	0.572									Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				27	49					0	0	0	0	T	17116981	T	T	17116981	2	4	276	1	0	0	0	0	0	0	0	1	5953	564	20	4		4	FLCN	17	17116981	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	54852	17116981	64078229	1639	51528											
MYO15A	51168	broad.mit.edu	37	chr17	18045392	18045392	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgccttcctcctgtccttaGctgttccttaaggaacacct	6	14	7	14	0	0	0	0	0	0	0	4	1	4	1	6	1	3	2	6	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:18045392G>A	uc010vxh.1	+	23	5988	c.5650_splice	c.e23-1	p.L1884_splice		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV						sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CCTGTCCTTAGCTGTTCCTTA	0.577													71	44					0	0	0	0	A	18045392	A	A	18045392	5	1	276	1	0	0	0	0	0	0	1	0	10116	985	34	4	5735	4	MYO15A	17	18045392	Splice_Site	SNP	G	TCGA-D6-6516-01A-11D-1870-08	928411	18045392	63149818	1640	51529											
ZNF286B	729288	broad.mit.edu	37	chr17	18566179	18566179	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtatggaaggcataagatcCtttgggaactctgtcttcag	10	13	11	7	0	3	1	1	0	2	1	4	3	4	3	1	3	1	2	1	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:18566179C>T	uc010vyd.1	-	5	891	c.640G>A	c.(640-642)GGA>AGA	p.G214R		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCATAAGATCCTTTGGGAACT	0.343													21	28					0	0	0	0	T	18566179	T	T	18566179	3	4	276	1	0	0	0	0	1	0	0	0	17891	690	24	4	932	4	ZNF286B	17	18566179	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	520787	18566179	62629031	1641	51530											
EPN2	22905	broad.mit.edu	37	chr17	19235287	19235287	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccggaaaacacctgagtcCttcctgggccccaacgcggc	8	5	11	17	3	0	1	0	1	0	0	2	2	2	2	6	3	2	0	6	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:19235287C>T	uc002gvd.3	+	10	1981	c.1533C>T	c.(1531-1533)TCC>TCT	p.S511S	EPN2_uc010cql.1_Silent_p.S220S|EPN2_uc002gve.3_Silent_p.S454S|EPN2_uc002gvf.3_Silent_p.S226S|EPN2_uc010vyo.1_Silent_p.S219S|EPN2_uc010vyp.1_Silent_p.S447S|EPN2_uc010vyq.1_Silent_p.S448S|EPN2_uc002gvh.1_Intron|EPN2_uc002gvj.3_Silent_p.S174S	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	511	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CACCTGAGTCCTTCCTGGGCC	0.617													13	71					0	0	0	0	T	19235287	T	T	19235287	2	4	276	1	0	0	0	0	0	0	0	1	5210	668	24	4		4	EPN2	17	19235287	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	669108	19235287	61959923	1642	51531											
B9D1	27077	broad.mit.edu	37	chr17	19247153	19247153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggtctgtgtactcgggcCgccgccccatgaaccagctg	5	8	14	14	3	1	1	0	1	1	0	2	1	1	1	5	3	3	2	5	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:19247153C>T	uc002gvk.3	-	6	586	c.422G>A	c.(421-423)CGG>CAG	p.R141Q	B9D1_uc010cqm.1_Missense_Mutation_p.G117S|B9D1_uc002gvl.3_Missense_Mutation_p.G117S|B9D1_uc010vyr.1_Missense_Mutation_p.G161S|B9D1_uc010vys.1_Missense_Mutation_p.G192S	NM_015681	NP_056496	Q9UPM9	B9D1_HUMAN	B9 protein	141					cilium assembly	centrosome|microtubule basal body	protein binding				0	all_cancers(12;2.04e-05)|all_epithelial(12;0.000806)|Hepatocellular(7;0.00345)|Breast(13;0.143)					GTACTCGGGCCGCCGCCCCAT	0.622													15	21					0	0	0	0	T	19247153	T	T	19247153	3	4	276	1	0	0	0	0	1	0	0	0	1279	652	23	1	200	1	B9D1	17	19247153	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	11866	19247153	61948057	1643	51532											
USP22	23326	broad.mit.edu	37	chr17	20911202	20911202	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctttgagatgaaaacaggctAcgatgggcagtttcttcata	12	12	10	7	1	2	2	1	2	1	1	2	4	2	2	0	2	2	3	0	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:20911202A>G	uc002gym.3	-	9	1415	c.1211T>C	c.(1210-1212)GTA>GCA	p.V404A	USP22_uc002gyn.3_Missense_Mutation_p.V392A|USP22_uc002gyl.3_Missense_Mutation_p.V299A	NM_015276	NP_056091	Q9UPT9	UBP22_HUMAN	ubiquitin thiolesterase 22	404					cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1						AAAACAGGCTACGATGGGCAG	0.483													25	66					0	0	0	0	G	20911202	G	G	20911202	3	3	276	1	0	0	0	0	1	0	0	0	17122	391	14	5	386	5	USP22	17	20911202	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1664049	20911202	60284008	1644	51533											
NOS2	4843	broad.mit.edu	37	chr17	26108184	26108184	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttgccatcactccgctgggGgaacacggtgatggccgacc	7	7	13	14	3	1	1	1	1	0	0	2	3	2	2	4	4	2	1	4	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:26108184G>A	uc002gzu.2	-	8	1006	c.742C>T	c.(742-744)CCC>TCC	p.P248S	NOS2_uc010crh.1_Missense_Mutation_p.P248S|NOS2_uc010wab.1_Missense_Mutation_p.P248S	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	248					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CTCCGCTGGGGGAACACGGTG	0.617													10	53					0	0	0	0	A	26108184	A	A	26108184	3	1	276	1	0	0	0	0	1	0	0	0	10597	1232	43	4	2799	4	NOS2	17	26108184	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5196982	26108184	55087026	1645	51534											
PIGS	94005	broad.mit.edu	37	chr17	26881400	26881400	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaggagtgacgggtcaaaGaaggcaagctcagaggatgt	13	6	17	5	1	2	3	2	1	0	2	2	6	2	6	0	5	1	2	0	5	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:26881400G>A	uc002hbo.2	-	12	1879	c.1506C>T	c.(1504-1506)TTC>TTT	p.F502F	UNC119_uc002hbk.2_5'Flank|UNC119_uc002hbm.2_5'Flank|PIGS_uc002hbn.2_Silent_p.F494F|PIGS_uc010wap.1_Silent_p.F441F	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	502	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					ACGGGTCAAAGAAGGCAAGCT	0.557													27	95					0	0	0	0	A	26881400	A	A	26881400	2	1	276	1	0	0	0	0	0	0	0	1	11953	933	33	2		2	PIGS	17	26881400	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	773216	26881400	54313810	1646	51535											
ALDOC	230	broad.mit.edu	37	chr17	26902186	26902186	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctggatggttcggacgaaGggaacaccattatcatcttt	10	12	10	9	2	2	0	1	0	1	0	4	4	3	3	2	4	1	1	2	4	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:26902186G>A	uc002hbp.2	-	3	424	c.279C>T	c.(277-279)CCC>CCT	p.P93P	ALDOC_uc010cro.2_Silent_p.P93P	NM_005165	NP_005156	P09972	ALDOC_HUMAN	fructose-bisphosphate aldolase C	93					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			ovary(1)	1	Lung NSC(42;0.00431)					TTCGGACGAAGGGAACACCAT	0.517											OREG0024278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	28					0	0	0	0	A	26902186	A	A	26902186	2	1	276	1	0	0	0	0	0	0	0	1	509	987	35	4		4	ALDOC	17	26902186	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	20786	26902186	54293024	1647	51536											
SEZ6	124925	broad.mit.edu	37	chr17	27309024	27309024	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctcgatgcctggggcttgtCctttccccacggttggggcc	2	11	13	15	2	0	0	0	0	0	0	3	1	2	0	6	5	1	2	6	5	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:27309024C>T	uc002hdp.2	-	2	283	c.89G>A	c.(88-90)GGA>GAA	p.G30E	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.G30E|SEZ6_uc002hdq.1_5'UTR|SEZ6_uc010crz.1_Missense_Mutation_p.G30E	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	30	Extracellular (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			TGGGGCTTGTCCTTTCCCCAC	0.592													6	27					0	0	0	0	T	27309024	T	T	27309024	3	4	276	1	0	0	0	0	1	0	0	0	14207	855	30	2	2972	2	SEZ6	17	27309024	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	406838	27309024	53886186	1648	51537											
EFCAB5	374786	broad.mit.edu	37	chr17	28380879	28380879	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaatgtcagctgcagaacAgggatcactcagagagtcag	14	6	12	9	0	4	3	4	0	0	3	4	5	4	4	0	1	3	2	0	1	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:28380879A>C	uc002het.2	+	10	2099	c.1907A>C	c.(1906-1908)CAG>CCG	p.Q636P	EFCAB5_uc010wbi.1_Missense_Mutation_p.Q379P|EFCAB5_uc010wbj.1_Missense_Mutation_p.Q580P|EFCAB5_uc010wbk.1_Missense_Mutation_p.Q293P|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Missense_Mutation_p.Q515P|EFCAB5_uc010csf.2_Missense_Mutation_p.Q515P	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	636							calcium ion binding			ovary(1)|skin(1)	2						GCTGCAGAACAGGGATCACTC	0.443													29	96					0	0	0	0	C	28380879	C	C	28380879	3	2	276	1	0	0	0	0	1	0	0	0	4960	188	7	5	1945	5	EFCAB5	17	28380879	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1071855	28380879	52814331	1649	51538											
CPD	1362	broad.mit.edu	37	chr17	28748832	28748832	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttcctggaacttacaacCttacagtagttttaactggg	10	15	8	8	0	0	0	0	0	0	0	1	1	1	1	2	2	5	3	2	2	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:28748832C>T	uc002hfb.1	+	4	1303	c.1288C>T	c.(1288-1290)CTT>TTT	p.L430F	CPD_uc010wbo.1_Missense_Mutation_p.L183F|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	430	Extracellular (Potential).|Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						AACTTACAACCTTACAGTAGT	0.343													15	89					0	0	0	0	T	28748832	T	T	28748832	3	4	276	1	0	0	0	0	1	0	0	0	3813	681	24	4	1302	4	CPD	17	28748832	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	367953	28748832	52446378	1650	51539											
NF1	4763	broad.mit.edu	37	chr17	29548871	29548871	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttttaaaaaattcaggctCtgctggttcttcatcagtta	10	18	6	7	0	5	0	3	0	2	0	5	0	5	0	0	2	1	4	0	2	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:29548871C>T	uc002hgg.2	+	15	1978	c.1645C>T	c.(1645-1647)CTG>TTG	p.L549L	NF1_uc002hgf.1_Silent_p.L549L|NF1_uc002hgh.2_Silent_p.L549L|NF1_uc010csn.1_Silent_p.L409L	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	549			L -> P (in NF1).		actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AATTCAGGCTCTGCTGGTTCT	0.308			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			25	33					0	0	0	0	T	29548871	T	T	29548871	2	4	276	1	0	0	0	0	0	0	0	1	10410	912	32	2		2	NF1	17	29548871	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	800039	29548871	51646339	1651	51540											
LIG3	3980	broad.mit.edu	37	chr17	33321400	33321400	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaggtgcataagaatggaGaccacttcagctacttcagc	12	9	9	11	0	2	2	2	0	0	2	3	3	3	2	2	2	4	2	2	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:33321400G>A	uc002hik.1	+	9	1669	c.1561G>A	c.(1561-1563)GAC>AAC	p.D521N	LIG3_uc002hij.2_Missense_Mutation_p.D521N|LIG3_uc010cth.1_Missense_Mutation_p.D530N	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	521					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	TAAGAATGGAGACCACTTCAG	0.517								Other_BER_factors					17	74					0	0	0	0	A	33321400	A	A	33321400	3	1	276	1	0	0	0	0	1	0	0	0	8823	942	33	2	1591	2	LIG3	17	33321400	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3772529	33321400	47873810	1652	51541											
RAD51L3	5892	broad.mit.edu	37	chr17	33433486	33433486	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcatgcaccacctggatcctCcggagagcttctgcctgaag	8	8	11	14	1	1	2	0	1	1	1	3	4	3	3	5	2	3	3	5	2	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:33433486C>T	uc002hir.2	-	6	751	c.495G>A	c.(493-495)CGG>CGA	p.R165R	RFFL_uc002hiq.2_Silent_p.R6R|RAD51L3_uc010ctj.2_5'UTR|RAD51L3_uc010wcd.1_Silent_p.R185R|RAD51L3_uc002his.2_Silent_p.R53R|RAD51L3_uc010ctk.2_Silent_p.R46R|RAD51L3_uc010wce.1_Silent_p.R46R|RAD51L3_uc002hit.2_Silent_p.R46R|RAD51L3_uc002hiu.2_5'UTR|RAD51L3_uc010wcf.1_RNA|RAD51L3_uc002hiw.1_RNA|RAD51L3_uc002hiv.1_RNA|RAD51L3_uc010ctl.1_RNA|RAD51L3_uc010ctm.1_RNA	NM_002878	NP_002869	O75771	RA51D_HUMAN	RAD51-like 3 isoform 1	165					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CCTGGATCCTCCGGAGAGCTT	0.567								Direct_reversal_of_damage|Homologous_recombination					9	17					0	0	0	0	T	33433486	T	T	33433486	2	4	276	1	0	0	0	0	0	0	0	1	13055	842	30	2		2	RAD51L3	17	33433486	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	112086	33433486	47761724	1653	51542											
SLFN11	91607	broad.mit.edu	37	chr17	33679468	33679468	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagatagctgggtcagctgtCcttggatggatcccaaacac	11	9	11	10	0	1	1	1	0	0	1	3	3	3	3	2	3	3	2	2	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:33679468C>T	uc010ctp.2	-	7	3055	c.2613G>A	c.(2611-2613)AGG>AGA	p.R871R	SLFN11_uc010ctq.2_Silent_p.R871R|SLFN11_uc002hjh.3_Silent_p.R871R|SLFN11_uc002hjg.3_Silent_p.R871R|SLFN11_uc010ctr.2_Silent_p.R871R	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	871						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGTCAGCTGTCCTTGGATGGA	0.483													38	169					0	0	0	0	T	33679468	T	T	33679468	2	4	276	1	0	0	0	0	0	0	0	1	14797	854	30	2		2	SLFN11	17	33679468	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	245982	33679468	47515742	1654	51543											
TADA2A	6871	broad.mit.edu	37	chr17	35783695	35783695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgctgaatgtgggccacctCcttttttcctctgcttgcag	4	15	10	12	0	1	1	0	1	1	0	3	1	3	1	4	1	3	3	4	1	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:35783695C>T	uc002hnt.2	+	3	269	c.112C>T	c.(112-114)CCT>TCT	p.P38S	TADA2A_uc002hnu.1_Missense_Mutation_p.P38S|TADA2A_uc002hnv.2_Missense_Mutation_p.P38S|TADA2A_uc010wdd.1_Missense_Mutation_p.P38S|TADA2A_uc002hnw.2_5'UTR	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	38	Cys-rich.				histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						TGGGCCACCTCCTTTTTTCCT	0.443													34	124					0	0	0	0	T	35783695	T	T	35783695	3	4	276	1	0	0	0	0	1	0	0	0	15576	855	30	2	118	2	TADA2A	17	35783695	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2104227	35783695	45411515	1655	51544											
MLLT6	4302	broad.mit.edu	37	chr17	36876005	36876005	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggttccctctggccgcaggtCccccatcagcagcctccccg	4	7	10	20	2	2	0	1	0	1	0	5	0	5	0	7	3	2	3	7	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:36876005C>T	uc002hqi.3	+	14	2025	c.2012C>T	c.(2011-2013)TCC>TTC	p.S671F	MLLT6_uc002hqj.2_Missense_Mutation_p.S106F|MLLT6_uc002hqk.3_Missense_Mutation_p.S2F	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	671					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					GGCCGCAGGTCCCCCATCAGC	0.682			T	MLL	AL								4	27					0	0	0	0	T	36876005	T	T	36876005	3	4	276	1	0	0	0	0	1	0	0	0	9683	855	30	2	2066	2	MLLT6	17	36876005	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1092310	36876005	44319205	1656	51545											
MED1	5469	broad.mit.edu	37	chr17	37564132	37564132	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggtgacttactatggctggGagagccacgctcatgctttg	7	12	13	9	1	1	2	1	1	0	1	1	3	1	2	1	3	3	3	1	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:37564132G>A	uc002hrv.3	-	17	4554	c.4342C>T	c.(4342-4344)CCC>TCC	p.P1448S	MED1_uc010wee.1_Missense_Mutation_p.P1276S|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1448	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		CTATGGCTGGGAGAGCCACGC	0.488										HNSCC(31;0.082)			21	69					0	0	0	0	A	37564132	A	A	37564132	3	1	276	1	0	0	0	0	1	0	0	0	9478	1174	41	2	407	2	MED1	17	37564132	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	688127	37564132	43631078	1657	51546											
MED1	5469	broad.mit.edu	37	chr17	37565007	37565007	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccatgcttggttatgggaGaggagcctggcttcccccca	6	10	13	12	0	0	1	0	0	0	1	2	3	2	2	5	4	2	3	5	4	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:37565007G>A	uc002hrv.3	-	17	3679	c.3467C>T	c.(3466-3468)TCT>TTT	p.S1156F	MED1_uc010wee.1_Missense_Mutation_p.S984F|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1156	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GGTTATGGGAGAGGAGCCTGG	0.468										HNSCC(31;0.082)			13	45					0	0	0	0	A	37565007	A	A	37565007	3	1	276	1	0	0	0	0	1	0	0	0	9478	942	33	2	1282	2	MED1	17	37565007	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	875	37565007	43630203	1658	51547											
PSMD3	5709	broad.mit.edu	37	chr17	38145046	38145046	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacgcccgggtctatgagttCctggacaagctggatgtggt	7	10	14	10	2	1	1	0	1	1	0	2	3	2	3	2	4	1	2	2	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:38145046C>T	uc002htn.1	+	4	824	c.660C>T	c.(658-660)TTC>TTT	p.F220F	PSMD3_uc010wen.1_RNA|PSMD3_uc010weo.1_Silent_p.F121F	NM_002809	NP_002800	O43242	PSMD3_HUMAN	proteasome 26S non-ATPase subunit 3	220					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			ovary(1)|pancreas(1)	2	Colorectal(19;0.000442)					TCTATGAGTTCCTGGACAAGC	0.547													18	120					0	0	0	0	T	38145046	T	T	38145046	2	4	276	1	0	0	0	0	0	0	0	1	12761	854	30	2		2	PSMD3	17	38145046	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	580039	38145046	43050164	1659	51548											
KRT39	390792	broad.mit.edu	37	chr17	39114919	39114933	+	In_Frame_Del	DEL	ATCCTTAATCTCCTT	-	-																															taagaagaaatgaccttcccAtccttaatctccttggtgat																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:39114919_39114933delATCCTTAATCTCCTT	uc002hvo.1	-	7	1432_1446	c.1396_1410delAAGGAGATTAAGGAT	c.(1396-1410)AAGGAGATTAAGGATdel	p.KEIKD466del	KRT39_uc010wfm.1_In_Frame_Del_p.KEIKD199del	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	466_470	Tail.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				TGACCTTCCCATCCTTAATCTCCTTGGTGATGGTG	0.498													---	---	---								-	39114933	-	-	39114919	7	5	276	1	0	1	0	1	0	0	0	0	8515	214	8	0	69	0	KRT39	17	39114919	In_Frame_Del	DEL	ATCCTTAATCTCCTT	TCGA-D6-6516-01A-11D-1870-08	969873	39114919	42080291	1660	51549											
KRT40	125115	broad.mit.edu	37	chr17	39138698	39138698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctctaacagctggcgaaggGacagttcactctcgtacctt	9	10	9	13	2	3	0	1	0	2	0	4	2	3	1	2	2	3	3	2	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:39138698G>A	uc010cxh.1	-	5	709	c.548C>T	c.(547-549)TCC>TTC	p.S183F	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	183	Rod.|Coil 1B.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				CTGGCGAAGGGACAGTTCACT	0.527													15	78					0	0	0	0	A	39138698	A	A	39138698	3	1	276	1	0	0	0	0	1	0	0	0	8517	1174	41	2	767	2	KRT40	17	39138698	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	23779	39138698	42056512	1661	51550											
KRT40	125115	broad.mit.edu	37	chr17	39140175	39140175	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcttggatcctggattcCagctctgcgttggtctcctc	3	16	10	12	1	3	0	0	0	3	0	7	2	5	2	3	3	2	3	3	3	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:39140175C>T	uc010cxh.1	-	3	512	c.351G>A	c.(349-351)CTG>CTA	p.L117L	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	117	Rod.|Coil 1A.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				TCCTGGATTCCAGCTCTGCGT	0.493													49	159					0	0	0	0	T	39140175	T	T	39140175	2	4	276	1	0	0	0	0	0	0	0	1	8517	581	21	4		4	KRT40	17	39140175	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1477	39140175	42055035	1662	51551											
KRT38	8687	broad.mit.edu	37	chr17	39596777	39596778	+	Missense_Mutation	DNP	CC	TT	TT																															cctctcgaggagtgtggcctCcagctccgcattctcctgct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:39596777_39596778CC>TT	uc002hwq.1	-	1	819_820	c.396_397GG>AA	c.(394-399)CTGGAG>CTAAAG	p.E133K		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	133	Coil 1A.|Rod.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				AGTGTGGCCTCCAGCTCCGCAT	0.594													18	101					0	0	0	0	TT	39596778	TT	TT	39596777	3	4	276	1	0	0	0	0	1	0	0	0	8514	864	30	2	1001	2	KRT38	17	39596777	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	456602	39596777	41598433	1663	51552											
KRT9	3857	broad.mit.edu	37	chr17	39724598	39724598	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagctggccacagtagcGgttcttcgtgtcttccaagc	6	11	11	13	2	2	0	0	0	2	0	4	0	3	0	2	2	4	4	2	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:39724598G>A	uc002hxe.3	-	6	1276	c.1210C>T	c.(1210-1212)CGC>TGC	p.R404C	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	404	Rod.|Coil 2.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				CCACAGTAGCGGTTCTTCGTG	0.507													14	86					0	0	0	0	A	39724598	A	A	39724598	3	1	276	1	0	0	0	0	1	0	0	0	8540	1116	39	1	669	1	KRT9	17	39724598	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	127821	39724598	41470612	1664	51553											
KRT14	3861	broad.mit.edu	37	chr17	39740157	39740157	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catctccacccacctggcctCtcagggcattcatctcctgc	6	10	6	19	0	4	0	2	0	3	0	7	0	4	0	5	2	1	1	5	2	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:39740157C>T	uc002hxf.1	-	4	843	c.782G>A	c.(781-783)AGA>AAA	p.R261K	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Missense_Mutation_p.R261K	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	261	Rod.|Linker 12.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				CACCTGGCCTCTCAGGGCATT	0.572													12	41					0	0	0	0	T	39740157	T	T	39740157	3	4	276	1	0	0	0	0	1	0	0	0	8490	913	32	2	656	2	KRT14	17	39740157	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	15559	39740157	41455053	1665	51554											
KRT14	3861	broad.mit.edu	37	chr17	39740512	39740512	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccatatagttctcacctcCtcgtggttcttcttcaggta	6	17	6	12	1	4	0	2	0	3	0	8	0	6	0	3	2	0	3	3	2	3	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:39740512C>T	uc002hxf.1	-	3	823	c.762G>A	c.(760-762)GAG>GAA	p.E254E	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Silent_p.E254E	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	254	Coil 1B.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				TTCTCACCTCCTCGTGGTTCT	0.393													14	126					0	0	0	0	T	39740512	T	T	39740512	2	4	276	1	0	0	0	0	0	0	0	1	8490	680	24	4		4	KRT14	17	39740512	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	355	39740512	41454698	1666	51555											
KRT14	3861	broad.mit.edu	37	chr17	39740538	39740538	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcttcttcaggtaggccaGctcctccttcaggctctcaa	6	13	8	14	0	5	0	3	0	3	0	8	0	7	0	3	3	1	4	3	3	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:39740538G>A	uc002hxf.1	-	3	797	c.736C>T	c.(736-738)CTG>TTG	p.L246L	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Silent_p.L246L	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	246	Coil 1B.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				AGGTAGGCCAGCTCCTCCTTC	0.468													27	122					0	0	0	0	A	39740538	A	A	39740538	2	1	276	1	0	0	0	0	0	0	0	1	8490	962	34	4		4	KRT14	17	39740538	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	26	39740538	41454672	1667	51556											
GHDC	84514	broad.mit.edu	37	chr17	40344298	40344298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagagaagaaggctagtcCttggcaccacaaggccccga	13	4	13	11	1	0	2	0	0	0	2	1	5	1	3	4	4	0	2	4	4	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:40344298C>T	uc002hzd.2	-	4	1334	c.850G>A	c.(850-852)GGA>AGA	p.G284R	GHDC_uc002hzg.1_Missense_Mutation_p.G284R|GHDC_uc010wgg.1_Missense_Mutation_p.G245R|GHDC_uc002hze.3_Missense_Mutation_p.G284R|GHDC_uc002hzf.3_Missense_Mutation_p.G284R|GHDC_uc010cxz.2_RNA	NM_032484	NP_115873	Q8N2G8	GHDC_HUMAN	LGP1 homolog isoform 1	284						endoplasmic reticulum|nuclear envelope					0		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		AAGGCTAGTCCTTGGCACCAC	0.632													20	130					0	0	0	0	T	40344298	T	T	40344298	3	4	276	1	0	0	0	0	1	0	0	0	6406	690	24	4	855	4	GHDC	17	40344298	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	603760	40344298	40850912	1668	51557											
PTRF	284119	broad.mit.edu	37	chr17	40556780	40556780	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agcagcgcgtgcacgtcgggGctgctcccgcgccgcaggtc	4	5	16	16	7	0	0	0	0	0	0	3	0	1	0	2	3	4	5	2	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:40556780G>A	uc002hzo.2	-	2	1257	c.1098C>T	c.(1096-1098)AGC>AGT	p.S366S	PTRF_uc010wgi.1_Silent_p.S348S	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	366					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		GCACGTCGGGGCTGCTCCCGC	0.736													4	9					0	0	0	0	A	40556780	A	A	40556780	2	1	276	1	0	0	0	0	0	0	0	1	12880	1194	42	4		4	PTRF	17	40556780	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	212482	40556780	40638430	1669	51558											
TUBG1	7283	broad.mit.edu	37	chr17	40765002	40765002	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcagacatactcagtgtttCccaaccaggacgagatgagc	12	8	10	11	1	1	3	1	1	0	2	2	5	2	4	2	1	4	2	2	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:40765002C>T	uc002ian.2	+	6	915	c.517C>T	c.(517-519)CCC>TCC	p.P173S		NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	173					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		CTCAGTGTTTCCCAACCAGGA	0.557													19	95					0	0	0	0	T	40765002	T	T	40765002	3	4	276	1	0	0	0	0	1	0	0	0	16832	855	30	2	539	2	TUBG1	17	40765002	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	208222	40765002	40430208	1670	51559											
CCR10	2826	broad.mit.edu	37	chr17	40832611	40832612	+	Missense_Mutation	DNP	CC	TT	TT																															cgagtatgcgtcctcttcatCcccagagtaatggccccagg																								rs138478451		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:40832611_40832612CC>TT	uc002iax.3	-	2	52_53	c.48_49GG>AA	c.(46-51)GGGGAT>GGAAAT	p.D17N	CNTNAP1_uc002iay.2_5'Flank|CNTNAP1_uc010wgs.1_5'Flank	NM_016602	NP_057686	P46092	CCR10_HUMAN	CC chemokine receptor 10	17	Extracellular (Potential).					integral to plasma membrane					0		Breast(137;0.000153)		BRCA - Breast invasive adenocarcinoma(366;0.14)		TCCTCTTCATCCCCAGAGTAAT	0.594													6	31					0	0	0	0	TT	40832612	TT	TT	40832611	3	4	276	1	0	0	0	0	1	0	0	0	2955	855	30	2	1043	2	CCR10	17	40832611	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	67609	40832611	40362599	1671	51560											
WNK4	65266	broad.mit.edu	37	chr17	40945659	40945659	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgagatggatttctcagacGgattcgggagattatccagc	10	10	13	8	3	1	3	1	0	1	3	4	7	2	5	1	3	1	0	1	3	1	3	rs149389156	by1000genomes	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:40945659G>A	uc002ibj.2	+	12	2228	c.2207G>A	c.(2206-2208)CGG>CAG	p.R736Q	WNK4_uc010wgx.1_Missense_Mutation_p.R400Q|WNK4_uc002ibk.1_Missense_Mutation_p.R508Q|WNK4_uc010wgy.1_Missense_Mutation_p.R80Q	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	736					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TTTCTCAGACGGATTCGGGAG	0.542													15	61					0	0	0	0	A	40945659	A	A	40945659	3	1	276	1	0	0	0	0	1	0	0	0	17448	1116	39	1	2253	1	WNK4	17	40945659	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	113048	40945659	40249551	1672	51561											
AOC2	314	broad.mit.edu	37	chr17	41001235	41001235	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggaggacctgacagctttttCcttgggaagccccctacccc	7	9	10	15	0	0	1	0	1	0	0	1	4	1	4	6	3	3	1	6	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:41001235C>T	uc002ibu.2	+	2	1756	c.1721C>T	c.(1720-1722)TCC>TTC	p.S574F	AOC2_uc002ibt.2_Missense_Mutation_p.S574F|AOC3_uc002ibv.2_5'Flank	NM_009590	NP_033720	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 isoform b	574					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			ovary(2)	2		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		ACAGCTTTTTCCTTGGGAAGC	0.612													22	42					0	0	0	0	T	41001235	T	T	41001235	3	4	276	1	0	0	0	0	1	0	0	0	727	855	30	2	1727	2	AOC2	17	41001235	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	55576	41001235	40193975	1673	51562											
VAT1	10493	broad.mit.edu	37	chr17	41170069	41170069	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacctttaggggaaatcttCttgatctcatccacgtagtc	9	13	7	12	1	3	1	1	1	3	0	6	2	4	2	3	2	0	1	3	2	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:41170069C>T	uc002icm.1	-	3	870	c.750G>A	c.(748-750)AAG>AAA	p.K250K	VAT1_uc010cyw.1_Silent_p.K116K|VAT1_uc010whk.1_Silent_p.K182K	NM_006373	NP_006364	Q99536	VAT1_HUMAN	vesicle amine transport protein 1	250						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		GGGAAATCTTCTTGATCTCAT	0.547													23	73					0	0	0	0	T	41170069	T	T	41170069	2	4	276	1	0	0	0	0	0	0	0	1	17197	912	32	2		2	VAT1	17	41170069	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	168834	41170069	40025141	1674	51563											
ETV4	2118	broad.mit.edu	37	chr17	41605896	41605896	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccgctgggggctagtaagaGtagccacccttggggccaaa	9	6	15	11	1	0	1	0	0	0	1	0	1	0	1	4	4	1	4	4	4	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:41605896G>A	uc002idw.2	-	13	1574	c.1446C>T	c.(1444-1446)TAC>TAT	p.Y482Y	ETV4_uc002idv.2_Silent_p.Y205Y|ETV4_uc010wih.1_Silent_p.Y428Y|ETV4_uc010czh.2_Silent_p.Y481Y|ETV4_uc010wii.1_Silent_p.Y443Y|ETV4_uc002idx.2_Silent_p.Y482Y|ETV4_uc010wij.1_Silent_p.Y443Y	NM_001986	NP_001977	P43268	ETV4_HUMAN	ets variant gene 4 (E1A enhancer binding	482					positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/ETV4(6)	bone(4)|soft_tissue(2)|ovary(1)	7		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)		GCTAGTAAGAGTAGCCACCCT	0.602			T	EWSR1|TMPRSS2|DDX5|KLK2|CANT1	Ewing sarcoma|Prostate carcinoma								8	24					0	0	0	0	A	41605896	A	A	41605896	2	1	276	1	0	0	0	0	0	0	0	1	5305	1024	36	4		4	ETV4	17	41605896	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	435827	41605896	39589314	1675	51564											
ASB16	92591	broad.mit.edu	37	chr17	42248418	42248419	+	Missense_Mutation	DNP	GG	AA	AA																															gaggccgccaacatgattgtGgagactgtgagcaaccagct																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:42248418_42248419GG>AA	uc002ifl.1	+	1	345_346	c.261_262GG>AA	c.(259-264)GTGGAG>GTAAAG	p.E88K	ASB16_uc002ifm.1_RNA	NM_080863	NP_543139	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box-containing protein	88					intracellular signal transduction		protein binding			kidney(2)	2		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		ACATGATTGTGGAGACTGTGAG	0.465													4	45					0	0	0	0	AA	42248419	AA	AA	42248418	3	1	276	1	0	0	0	0	1	0	0	0	1022	1335	47	4	263	4	ASB16	17	42248418	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	642522	42248418	38946792	1676	51565											
CDC27	996	broad.mit.edu	37	chr17	45234385	45234385	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggaagttcctgttcccagtgGgacagtatcaggtgaaatta	11	11	12	7	0	1	1	1	1	0	0	3	3	3	3	2	3	0	3	2	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:45234385G>A	uc002ild.3	-	7	863	c.736C>T	c.(736-738)CCA>TCA	p.P246S	CDC27_uc002ile.3_Missense_Mutation_p.P246S|CDC27_uc002ilf.3_Missense_Mutation_p.P246S|CDC27_uc010wkp.1_Missense_Mutation_p.P185S|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	246					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						GTTCCCAGTGGGACAGTATCA	0.363													7	72					0	0	0	0	A	45234385	A	A	45234385	3	1	276	1	0	0	0	0	1	0	0	0	3081	1232	43	4	1808	4	CDC27	17	45234385	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2985967	45234385	35960825	1677	51566											
ITGB3	3690	broad.mit.edu	37	chr17	45368447	45368447	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttgtatgggactcaagattgGagacacggtgaggtgggctg	9	10	17	5	1	1	3	1	1	0	2	1	5	1	4	0	5	0	2	0	5	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:45368447G>A	uc002ilj.2	+	9	1273	c.1253G>A	c.(1252-1254)GGA>GAA	p.G418E	ITGB3_uc002ili.1_Missense_Mutation_p.G418E|ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	418	Extracellular (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	CTCAAGATTGGAGACACGGTG	0.542													19	60					0	0	0	0	A	45368447	A	A	45368447	3	1	276	1	0	0	0	0	1	0	0	0	7934	1174	41	2	1287	2	ITGB3	17	45368447	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	134062	45368447	35826763	1678	51567											
FAM117A	81558	broad.mit.edu	37	chr17	47797715	47797715	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gctccccgcactgcgtggtcCcctaggagtggtgaacctcg	5	8	13	15	3	0	1	0	1	0	0	3	2	2	2	5	3	2	2	5	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:47797715C>T	uc002ipk.2	-	4	615	c.546G>A	c.(544-546)GGG>GGA	p.G182G	FAM117A_uc010wlz.1_5'UTR	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	182										ovary(1)	1						CTGCGTGGTCCCCTAGGAGTG	0.582													38	64					0	0	0	0	T	47797715	T	T	47797715	2	4	276	1	0	0	0	0	0	0	0	1	5437	610	22	4		4	FAM117A	17	47797715	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2429268	47797715	33397495	1679	51568											
FAM117A	81558	broad.mit.edu	37	chr17	47841404	47841404	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccggcccctccgcgccccgGcccccaggcacctccgcctc	2	3	9	27	5	0	0	0	0	0	0	3	0	2	0	11	3	0	1	11	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:47841404G>A	uc002ipk.2	-	1	115	c.46C>T	c.(46-48)CCG>TCG	p.P16S	FAM117A_uc010wlz.1_Intron	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	16										ovary(1)	1						ccgcgccccggcccccaggca	0.512													3	2					0	0	0	0	A	47841404	A	A	47841404	3	1	276	1	0	0	0	0	1	0	0	0	5437	1203	42	4	1347	4	FAM117A	17	47841404	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	43689	47841404	33353806	1680	51569											
SGCA	6442	broad.mit.edu	37	chr17	48252743	48252744	+	Missense_Mutation	DNP	GG	AA	AA																															caatgtgcacacaggtgagcGgctgcctccccgcgtggaca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:48252743_48252744GG>AA	uc002iqi.2	+	9	1145_1146	c.1109_1110GG>AA	c.(1108-1110)CGG>CAA	p.R370Q	SGCA_uc002iqj.2_Missense_Mutation_p.R246Q|SGCA_uc010wmi.1_RNA|HILS1_uc010wmj.1_5'Flank|HILS1_uc002iqk.2_Intron|HILS1_uc002iql.2_5'Flank	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	370	Cytoplasmic (Potential).				muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						ACAGGTGAGCGGCTGCCTCCCC	0.649													5	22					0	0	0	0	AA	48252744	AA	AA	48252743	3	1	276	1	0	0	0	0	1	0	0	0	14264	1116	39	1	1143	1	SGCA	17	48252743	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	411339	48252743	32942467	1681	51570											
TMEM92	162461	broad.mit.edu	37	chr17	48356592	48356592	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctgggcccaactcccacaGagccaccccctccctacagc	8	4	7	22	0	0	1	0	0	0	1	2	1	2	1	7	1	4	0	7	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:48356592G>A	uc002iqn.1	+	5	433	c.403G>A	c.(403-405)GAG>AAG	p.E135K		NM_153229	NP_694961	Q6UXU6	TMM92_HUMAN	transmembrane protein 92 precursor	135	Pro-rich.|Cytoplasmic (Potential).					integral to membrane					0						AACTCCCACAGAGCCACCCCC	0.597													31	197					0	0	0	0	A	48356592	A	A	48356592	3	1	276	1	0	0	0	0	1	0	0	0	16287	943	33	2	421	2	TMEM92	17	48356592	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	103849	48356592	32838618	1682	51571											
CACNA1G	8913	broad.mit.edu	37	chr17	48669144	48669144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaagtttgcctctgagcGggatggggacaccctgccag	7	8	14	12	1	1	1	0	1	1	0	1	3	1	3	3	3	4	2	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:48669144G>A	uc002irk.1	+	12	3056	c.2684G>A	c.(2683-2685)CGG>CAG	p.R895Q	CACNA1G_uc002iri.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irj.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irl.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irm.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irn.1_Missense_Mutation_p.R895Q|CACNA1G_uc002iro.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irp.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irq.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irr.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irs.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irt.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irv.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irw.1_Missense_Mutation_p.R895Q|CACNA1G_uc002iru.1_Missense_Mutation_p.R895Q|CACNA1G_uc002irx.1_Missense_Mutation_p.R808Q|CACNA1G_uc002iry.1_Missense_Mutation_p.R808Q|CACNA1G_uc002irz.1_Missense_Mutation_p.R808Q|CACNA1G_uc002isa.1_Missense_Mutation_p.R808Q|CACNA1G_uc002isb.1_Missense_Mutation_p.R808Q|CACNA1G_uc002isc.1_Missense_Mutation_p.R808Q|CACNA1G_uc002isd.1_Missense_Mutation_p.R808Q|CACNA1G_uc002ise.1_Missense_Mutation_p.R808Q|CACNA1G_uc002isf.1_Missense_Mutation_p.R808Q|CACNA1G_uc002isg.1_Missense_Mutation_p.R808Q|CACNA1G_uc002ish.1_Missense_Mutation_p.R808Q|CACNA1G_uc002isi.1_Missense_Mutation_p.R808Q	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	895	Extracellular (Potential).|II.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCCTCTGAGCGGGATGGGGAC	0.602													10	37					0	0	0	0	A	48669144	A	A	48669144	3	1	276	1	0	0	0	0	1	0	0	0	2556	1116	39	1	2730	1	CACNA1G	17	48669144	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	312552	48669144	32526066	1683	51572											
SPAG9	9043	broad.mit.edu	37	chr17	49098644	49098644	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctttaagggagtatcagtaGgaattgttgccacatctgaa	12	12	10	7	0	2	1	1	1	1	0	2	3	2	3	2	2	1	3	2	2	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:49098644G>A	uc002itc.2	-	7	1075	c.866C>T	c.(865-867)CCT>CTT	p.P289L	SPAG9_uc002itb.2_Missense_Mutation_p.P275L|SPAG9_uc002itd.2_Missense_Mutation_p.P275L|SPAG9_uc002itf.2_Missense_Mutation_p.P110L|SPAG9_uc002ita.2_Missense_Mutation_p.P132L|SPAG9_uc002ite.2_Missense_Mutation_p.P119L	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	289					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			AGTATCAGTAGGAATTGTTGC	0.393													31	138					0	0	0	0	A	49098644	A	A	49098644	3	1	276	1	0	0	0	0	1	0	0	0	15051	1000	35	4	3195	4	SPAG9	17	49098644	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	429500	49098644	32096566	1684	51573											
KIF2B	84643	broad.mit.edu	37	chr17	51901498	51901498	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcaaggtgtatgatttgttGaactggaagaagaagctgca	13	10	14	4	0	0	4	0	2	0	2	0	5	0	5	0	3	3	5	0	3	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:51901498G>A	uc002iua.2	+	1	1260	c.1104G>A	c.(1102-1104)TTG>TTA	p.L368L	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	368	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						ATGATTTGTTGAACTGGAAGA	0.463													13	85					0	0	0	0	A	51901498	A	A	51901498	2	1	276	1	0	0	0	0	0	0	0	1	8337	1281	45	2		2	KIF2B	17	51901498	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2802854	51901498	29293712	1685	51574											
AKAP1	8165	broad.mit.edu	37	chr17	55184035	55184035	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcttgggcccagacactgcgGagcctgccacagcagaggca	9	5	13	14	1	1	2	0	0	1	2	1	3	1	3	3	3	4	2	3	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:55184035G>A	uc002iux.2	+	2	1441	c.1210G>A	c.(1210-1212)GAG>AAG	p.E404K	AKAP1_uc010wnl.1_Missense_Mutation_p.E404K|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Missense_Mutation_p.E404K	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	404					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					AGACACTGCGGAGCCTGCCAC	0.622													11	64					0	0	0	0	A	55184035	A	A	55184035	3	1	276	1	0	0	0	0	1	0	0	0	445	1175	41	2	1212	2	AKAP1	17	55184035	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3282537	55184035	26011175	1686	51575											
EPX	8288	broad.mit.edu	37	chr17	56274318	56274318	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatcccacccaatgaccccCgcatcaagaaccagcgtgac	13	4	7	17	2	1	4	1	2	0	2	2	4	2	4	5	0	2	1	5	0	3	0	rs138263557		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:56274318C>T	uc002ivq.2	+	7	906	c.820C>T	c.(820-822)CGC>TGC	p.R274C		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	274					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						CAATGACCCCCGCATCAAGAA	0.483													21	68					0	0	0	0	T	56274318	T	T	56274318	3	4	276	1	0	0	0	0	1	0	0	0	5224	652	23	1	846	1	EPX	17	56274318	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1090283	56274318	24920892	1687	51576											
EPX	8288	broad.mit.edu	37	chr17	56280672	56280672	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttcagaagagcccgagacGgagacaggtaagtgacccta	14	5	13	9	2	1	5	1	1	0	4	1	7	1	5	2	2	1	2	2	2	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:56280672G>A	uc002ivq.2	+	11	2025	c.1939G>A	c.(1939-1941)GGA>AGA	p.G647R		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	647				RDGDRFWWQKRGVFTK -> ETETGSGGRTRCFHQ (in Ref. 3; AA sequence).	hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						AGCCCGAGACGGAGACAGGTA	0.507													22	39					0	0	0	0	A	56280672	A	A	56280672	3	1	276	1	0	0	0	0	1	0	0	0	5224	1117	39	1	1981	1	EPX	17	56280672	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6354	56280672	24914538	1688	51577											
MKS1	54903	broad.mit.edu	37	chr17	56285488	56285488	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaagattcatcctcatggagGaagaaggcttcaaacgtgaa	15	8	11	7	1	3	3	3	1	0	2	4	6	4	5	1	3	1	1	1	3	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:56285488G>A	uc002ivr.1	-	13	1218	c.1143C>T	c.(1141-1143)TTC>TTT	p.F381F	MKS1_uc010wnq.1_Silent_p.F178F|MKS1_uc002ivs.1_Silent_p.F381F	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	381	B9.				cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1						CCTCATGGAGGAAGAAGGCTT	0.527													10	50					0	0	0	0	A	56285488	A	A	56285488	2	1	276	1	0	0	0	0	0	0	0	1	9662	1165	41	2		2	MKS1	17	56285488	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4816	56285488	24909722	1689	51578											
RNF43	54894	broad.mit.edu	37	chr17	56435132	56435132	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtgcacagttgcatcctgggGccgagagccaggggtgggct	6	7	18	10	1	0	1	0	0	0	1	1	2	1	1	3	5	3	4	3	5	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:56435132G>A	uc002iwf.2	-	8	3961	c.2005C>T	c.(2005-2007)CCC>TCC	p.P669S	RNF43_uc010wnv.1_Missense_Mutation_p.P628S|RNF43_uc002iwh.3_Missense_Mutation_p.P669S|RNF43_uc002iwg.3_Missense_Mutation_p.P669S|RNF43_uc010dcw.2_Missense_Mutation_p.P542S	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	669	Pro-rich.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCATCCTGGGGCCGAGAGCCA	0.597													33	163					0	0	0	0	A	56435132	A	A	56435132	3	1	276	1	0	0	0	0	1	0	0	0	13560	1203	42	4	354	4	RNF43	17	56435132	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	149644	56435132	24760078	1690	51579											
C17orf47	284083	broad.mit.edu	37	chr17	56620991	56620991	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcctacggggaactctgactCcttgggggttctggaccttg	5	12	13	11	1	2	1	0	1	2	0	4	3	4	3	3	5	2	1	3	5	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:56620991C>T	uc002iwq.1	-	1	693	c.557G>A	c.(556-558)GGA>GAA	p.G186E	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	186										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AACTCTGACTCCTTGGGGGTT	0.433													33	154					0	0	0	0	T	56620991	T	T	56620991	3	4	276	1	0	0	0	0	1	0	0	0	1865	855	30	2	1163	2	C17orf47	17	56620991	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	185859	56620991	24574219	1691	51580											
TEX14	56155	broad.mit.edu	37	chr17	56664947	56664947	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgactttatactcacttttcCattttaagtgtacctttcca	9	19	3	10	0	1	1	1	1	0	0	3	1	3	1	3	0	2	1	3	0	4	9			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:56664947C>T	uc010dcz.1	-	17	2919	c.2801G>A	c.(2800-2802)TGG>TAG	p.W934*	TEX14_uc002iwr.1_Nonsense_Mutation_p.W928*|TEX14_uc002iws.1_Nonsense_Mutation_p.W928*|TEX14_uc010dda.1_Nonsense_Mutation_p.W708*	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	934						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTCACTTTTCCATTTTAAGTG	0.328											OREG0024616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	31					0	0	0	0	T	56664947	T	T	56664947	4	4	276	1	0	0	0	0	0	1	0	0	15844	595	21	4	1760	4	TEX14	17	56664947	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	43956	56664947	24530263	1692	51581											
HEATR6	63897	broad.mit.edu	37	chr17	58143574	58143574	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtttaaattctcttacctttGgagaagggtctttcaatgta	10	17	8	6	0	3	1	1	0	2	1	4	2	3	1	1	2	1	2	1	2	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:58143574G>A	uc002iyk.1	-	9	1429	c.1412C>T	c.(1411-1413)CCA>CTA	p.P471L	HEATR6_uc010ddk.1_Missense_Mutation_p.P10L|HEATR6_uc010wos.1_Missense_Mutation_p.P303L	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	471	HEAT 2.						binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			TCTTACCTTTGGAGAAGGGTC	0.383													41	39					0	0	0	0	A	58143574	A	A	58143574	3	1	276	1	0	0	0	0	1	0	0	0	7072	1348	47	4	2181	4	HEATR6	17	58143574	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1478627	58143574	23051636	1693	51582											
CA4	762	broad.mit.edu	37	chr17	58235145	58235145	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcggtgctggcctttctggTggaggtgggactcccatccc	3	11	15	12	1	1	0	0	0	1	0	3	2	3	2	3	6	2	1	3	6	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:58235145T>G	uc002iym.3	+	5	603	c.509T>G	c.(508-510)GTG>GGG	p.V170G	CA4_uc010wou.1_Intron	NM_000717	NP_000708	P22748	CAH4_HUMAN	carbonic anhydrase IV precursor	170					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	GCCTTTCTGGTGGAGGTGGGA	0.587													5	35					0	0	0	0	G	58235145	G	G	58235145	3	3	276	1	0	0	0	0	1	0	0	0	2530	1696	59	5	527	5	CA4	17	58235145	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	91571	58235145	22960065	1694	51583											
APPBP2	10513	broad.mit.edu	37	chr17	58539249	58539249	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctagcagtgtatcagaataTtttgggtgtttggatccaaa	11	15	10	5	0	2	1	1	0	1	1	3	2	3	2	1	2	1	3	1	2	5	6	rs144286983		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:58539249T>A	uc002iys.1	-	8	1146	c.858A>T	c.(856-858)AAA>AAT	p.K286N	APPBP2_uc010ddl.1_Missense_Mutation_p.K215N	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	286					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			TATCAGAATATTTTGGGTGTT	0.284													66	165					0	0	0	0	A	58539249	A	A	58539249	3	1	276	1	0	0	0	0	1	0	0	0	816	1490	52	5	923	5	APPBP2	17	58539249	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	304104	58539249	22655961	1695	51584											
PPM1D	8493	broad.mit.edu	37	chr17	58740467	58740467	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggtttcagctgagatagctCgagagaatgtccaaggtgta	12	10	13	6	1	1	2	1	1	0	2	3	5	2	2	1	2	2	4	1	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:58740467C>T	uc002iyt.1	+	6	1594	c.1372C>T	c.(1372-1374)CGA>TGA	p.R458*	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	458					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			TGAGATAGCTCGAGAGAATGT	0.433											OREG0031485	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	17	71					0	0	0	0	T	58740467	T	T	58740467	4	4	276	1	0	0	0	0	0	1	0	0	12397	876	31	1	1394	1	PPM1D	17	58740467	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	201218	58740467	22454743	1696	51585											
ACE	1636	broad.mit.edu	37	chr17	61574518	61574518	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcgctcagaagggcccctcCcagacagcggccgcgtcagc	7	4	12	18	4	2	2	2	0	0	2	4	2	3	2	4	2	2	1	4	2	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:61574518C>T	uc002jau.1	+	25	3734	c.3712C>T	c.(3712-3714)CCA>TCA	p.P1238S	ACE_uc002jav.1_Missense_Mutation_p.P664S|ACE_uc010ddv.1_Missense_Mutation_p.P465S|ACE_uc010wpj.1_Missense_Mutation_p.P623S|ACE_uc002jaw.1_Intron|ACE_uc010wpk.1_Missense_Mutation_p.P443S	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	1238	Extracellular (Potential).				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	AGGGCCCCTCCCAGACAGCGG	0.547													7	20					0	0	0	0	T	61574518	T	T	61574518	3	4	276	1	0	0	0	0	1	0	0	0	136	623	22	4	4013	4	ACE	17	61574518	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2834051	61574518	19620692	1697	51586											
GH2	2689	broad.mit.edu	37	chr17	61957743	61957743	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcaggaatgtctcgacctTgtccatgtccttcctgaagc	7	11	10	13	2	1	1	0	1	1	0	5	3	4	2	4	1	1	1	4	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:61957743T>G	uc002jco.1	-	5	654	c.592A>C	c.(592-594)AAG>CAG	p.K198Q	GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_3'UTR|GH2_uc002jcm.1_Silent_p.T196T|GH2_uc002jcn.1_Missense_Mutation_p.K183Q	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	198						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						GTCTCGACCTTGTCCATGTCC	0.572													29	57					0	0	0	0	G	61957743	G	G	61957743	3	3	276	1	0	0	0	0	1	0	0	0	6405	1821	63	5	153	5	GH2	17	61957743	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	383225	61957743	19237467	1698	51587											
SCN4A	6329	broad.mit.edu	37	chr17	62050171	62050171	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caagcactcagggcccagagGcaccagggtgcacagagatg	12	3	14	12	0	1	2	1	0	0	2	1	3	1	2	2	3	2	3	2	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:62050171G>A	uc002jds.1	-	1	108	c.31C>T	c.(31-33)CCT>TCT	p.P11S		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	11				VP -> AR (in Ref. 1; AAA60554).	muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GGGCCCAGAGGCACCAGGGTG	0.677													10	18					0	0	0	0	A	62050171	A	A	62050171	3	1	276	1	0	0	0	0	1	0	0	0	13985	1203	42	4	5575	4	SCN4A	17	62050171	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	92428	62050171	19145039	1699	51588											
POLG2	11232	broad.mit.edu	37	chr17	62479090	62479090	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccaaagcaaccttaataggGgctaaacaagggtgaagttt	15	9	10	7	0	0	1	0	1	0	0	1	1	1	1	2	3	3	3	2	3	8	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:62479090G>A	uc002jei.2	-	6	1220	c.1137C>T	c.(1135-1137)GCC>GCT	p.A379A		NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	379					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			CCTTAATAGGGGCTAAACAAG	0.353													9	62					0	0	0	0	A	62479090	A	A	62479090	2	1	276	1	0	0	0	0	0	0	0	1	12256	1219	43	4		4	POLG2	17	62479090	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	428919	62479090	18716120	1700	51589											
SMURF2	64750	broad.mit.edu	37	chr17	62577101	62577101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgccagggctagaatattcgGatgccggtctattgaaaatt	11	12	11	7	2	1	2	0	1	1	1	2	3	1	3	2	3	2	1	2	3	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:62577101G>A	uc002jep.1	-	8	966	c.578C>T	c.(577-579)TCC>TTC	p.S193F	SMURF2_uc002jeq.1_5'UTR|SMURF2_uc002jer.1_5'UTR	NM_022739	NP_073576	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	193					BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			AGAATATTCGGATGCCGGTCT	0.383													13	75					0	0	0	0	A	62577101	A	A	62577101	3	1	276	1	0	0	0	0	1	0	0	0	14884	1174	41	2	1716	2	SMURF2	17	62577101	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	98011	62577101	18618109	1701	51590											
APOH	350	broad.mit.edu	37	chr17	64222175	64222175	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caagaaaaactgatcgtgttGggatattcaaaagtcgtata	16	11	9	5	2	1	2	1	1	0	1	3	3	1	3	0	1	1	2	0	1	8	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:64222175G>A	uc002jfn.3	-	3	368	c.309C>T	c.(307-309)CCC>CCT	p.P103P		NM_000042	NP_000033	P02749	APOH_HUMAN	apolipoprotein H precursor	103	Sushi 2.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding				0			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			TGATCGTGTTGGGATATTCAA	0.363													27	28					0	0	0	0	A	64222175	A	A	64222175	2	1	276	1	0	0	0	0	0	0	0	1	804	1335	47	4		4	APOH	17	64222175	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1645074	64222175	16973035	1702	51591											
HELZ	9931	broad.mit.edu	37	chr17	65105256	65105256	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agcctcccctataggtaatcCcgaggggttctcatcaatga	10	10	9	12	1	2	1	2	1	1	0	5	2	4	1	4	3	1	2	4	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:65105256C>T	uc010wqk.1	-	29	4655	c.4468G>A	c.(4468-4470)GGA>AGA	p.G1490R	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.G1489R|HELZ_uc010der.2_Missense_Mutation_p.G33R	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					ATAGGTAATCCCGAGGGGTTC	0.448													15	102					0	0	0	0	T	65105256	T	T	65105256	3	4	276	1	0	0	0	0	1	0	0	0	7088	632	22	4	1383	4	HELZ	17	65105256	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	883081	65105256	16089954	1703	51592											
HELZ	9931	broad.mit.edu	37	chr17	65190132	65190132	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtgattcccctaggtggtgGgcggaaatgccaaccattac	9	10	12	10	1	0	1	0	1	0	0	1	2	1	2	4	4	3	0	4	4	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:65190132G>A	uc010wqk.1	-	9	695	c.508C>T	c.(508-510)CCA>TCA	p.P170S	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.P170S	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CTAGGTGGTGGGCGGAAATGC	0.368													13	23					0	0	0	0	A	65190132	A	A	65190132	3	1	276	1	0	0	0	0	1	0	0	0	7088	1232	43	4	5420	4	HELZ	17	65190132	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	84876	65190132	16005078	1704	51593											
NOL11	25926	broad.mit.edu	37	chr17	65715796	65715796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttaatttcattaggtttctGatcagaaacccttggggagc	10	14	9	8	0	3	2	2	1	1	1	3	3	3	3	1	3	2	1	1	3	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:65715796G>A	uc002jgd.1	+	2	151	c.148G>A	c.(148-150)GAT>AAT	p.D50N	NOL11_uc010wql.1_5'UTR|NOL11_uc010deu.1_5'Flank	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	50						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTAGGTTTCTGATCAGAAACC	0.323													10	24					0	0	0	0	A	65715796	A	A	65715796	3	1	276	1	0	0	0	0	1	0	0	0	10575	1290	45	2	154	2	NOL11	17	65715796	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	525664	65715796	15479414	1705	51594											
ARSG	22901	broad.mit.edu	37	chr17	66352844	66352844	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgttacactgacgtggccctCcctctttatgaaaacctcaa	10	12	6	13	1	2	2	1	2	1	0	3	2	3	2	3	1	2	1	3	1	5	3	rs115207014	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:66352844C>T	uc002jhc.2	+	6	1399	c.603C>T	c.(601-603)CTC>CTT	p.L201L	ARSG_uc002jhb.1_Silent_p.L37L	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	201					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			ACGTGGCCCTCCCTCTTTATG	0.483													12	40					0	0	0	0	T	66352844	T	T	66352844	2	4	276	1	0	0	0	0	0	0	0	1	994	842	30	2		2	ARSG	17	66352844	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	637048	66352844	14842366	1706	51595											
ABCA6	23460	broad.mit.edu	37	chr17	67124789	67124789	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccagtagtaaaggcaaaagGgctacaaatattcaaaatcc	18	8	7	8	0	1	0	1	0	0	0	3	0	3	0	2	2	1	4	2	2	10	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:67124789G>A	uc002jhw.1	-	8	1265	c.1090C>T	c.(1090-1092)CCT>TCT	p.P364S		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	364	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					AAGGCAAAAGGGCTACAAATA	0.373													15	107					0	0	0	0	A	67124789	A	A	67124789	3	1	276	1	0	0	0	0	1	0	0	0	36	1232	43	4	3891	4	ABCA6	17	67124789	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	771945	67124789	14070421	1707	51596											
DNAI2	64446	broad.mit.edu	37	chr17	72310278	72310278	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcagcaaccaagtccagaaGaagaccaggtggtggaggag	15	3	15	8	0	0	3	0	0	0	3	1	5	1	5	3	4	3	2	3	4	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:72310278G>A	uc002jkf.2	+	13	1840	c.1741G>A	c.(1741-1743)GAA>AAA	p.E581K	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	581					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						AAGTCCagaagaagaccaggt	0.388									Kartagener_syndrome				11	45					0	0	0	0	A	72310278	A	A	72310278	3	1	276	1	0	0	0	0	1	0	0	0	4632	943	33	2	1787	2	DNAI2	17	72310278	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5185489	72310278	8884932	1708	51597											
GRIN2C	2905	broad.mit.edu	37	chr17	72843643	72843643	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcgcccacagcagccacacgGacttgccgatagtgaaagct	11	5	11	14	3	0	1	0	1	0	0	0	3	0	2	3	1	4	2	3	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:72843643G>A	uc002jlt.1	-	9	1961	c.1805C>T	c.(1804-1806)TCC>TTC	p.S602F	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.S602F	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	602	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CAGCCACACGGACTTGCCGAT	0.632													11	36					0	0	0	0	A	72843643	A	A	72843643	3	1	276	1	0	0	0	0	1	0	0	0	6820	1174	41	2	1916	2	GRIN2C	17	72843643	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	533365	72843643	8351567	1709	51598											
USH1G	124590	broad.mit.edu	37	chr17	72916606	72916606	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcgcacgcattccatgtggcCcttcatggcagccatgtcca	7	9	10	15	2	1	0	1	0	0	0	3	0	3	0	4	2	1	3	4	2	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:72916606C>T	uc002jme.1	-	2	508	c.325G>A	c.(325-327)GGC>AGC	p.G109S	USH1G_uc010wro.1_Missense_Mutation_p.G6S	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	109	ANK 3.				equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					TCCATGTGGCCCTTCATGGCA	0.607													48	50					0	0	0	0	T	72916606	T	T	72916606	3	4	276	1	0	0	0	0	1	0	0	0	17103	623	22	4	1068	4	USH1G	17	72916606	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	72963	72916606	8278604	1710	51599											
C17orf28	283987	broad.mit.edu	37	chr17	72950299	72950299	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcagcggggcgggagccctCcatggaggtgccctcctggg	4	5	19	13	2	0	0	0	0	0	0	2	2	2	2	4	7	3	1	4	7	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:72950299C>T	uc002jmj.3	-	14	1947	c.1798G>A	c.(1798-1800)GAG>AAG	p.E600K	C17orf28_uc002jmi.2_Missense_Mutation_p.E2K|C17orf28_uc010wrs.1_Missense_Mutation_p.E399K	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	600						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					CGGGAGCCCTCCATGGAGGTG	0.687													4	17					0	0	0	0	T	72950299	T	T	72950299	3	4	276	1	0	0	0	0	1	0	0	0	1860	864	30	2	592	2	C17orf28	17	72950299	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	33693	72950299	8244911	1711	51600											
RNF157	114804	broad.mit.edu	37	chr17	74151749	74151749	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agccagacatggaggagacgGtgtcagtgctgatctgggag	10	7	17	7	1	2	3	1	1	1	2	2	6	2	5	1	4	2	1	1	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:74151749G>A	uc002jqz.2	-	15	1661	c.1592C>T	c.(1591-1593)ACC>ATC	p.T531I	RNF157_uc002jra.2_Missense_Mutation_p.T531I|uc002jrb.1_RNA	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	531	Ser-rich.						zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			GGAGGAGACGGTGTCAGTGCT	0.622													18	11					0	0	0	0	A	74151749	A	A	74151749	3	1	276	1	0	0	0	0	1	0	0	0	13519	1261	44	4	467	4	RNF157	17	74151749	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1201450	74151749	7043461	1712	51601											
QRICH2	84074	broad.mit.edu	37	chr17	74276160	74276160	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctggtagagtggggggcgctCcctgagctgctgtcgcagcg	4	8	18	11	3	0	2	0	1	0	1	2	2	1	2	1	4	3	5	1	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:74276160C>T	uc002jrd.1	-	12	4384	c.4204G>A	c.(4204-4206)GAG>AAG	p.E1402K	QRICH2_uc010wsz.1_Intron|QRICH2_uc010dgw.1_Missense_Mutation_p.E246K	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1402							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						GGGGGGCGCTCCCTGAGCTGC	0.687													11	61					0	0	0	0	T	74276160	T	T	74276160	3	4	276	1	0	0	0	0	1	0	0	0	12945	864	30	2	819	2	QRICH2	17	74276160	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	124411	74276160	6919050	1713	51602											
RHBDF2	79651	broad.mit.edu	37	chr17	74475253	74475253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caggtcacgctggcacgaggCcttcaggcggccgtagcgca	7	5	15	14	5	2	0	2	0	0	0	2	1	2	0	2	5	1	4	2	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:74475253C>T	uc002jrq.1	-	5	759	c.466G>A	c.(466-468)GCC>ACC	p.A156T	RHBDF2_uc002jrp.1_Missense_Mutation_p.A127T|RHBDF2_uc002jrr.1_Missense_Mutation_p.A8T|RHBDF2_uc010wtf.1_Missense_Mutation_p.A127T|RHBDF2_uc002jrs.1_Missense_Mutation_p.A127T	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	156	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						TGGCACGAGGCCTTCAGGCGG	0.677													14	42					0	0	0	0	T	74475253	T	T	74475253	3	4	276	1	0	0	0	0	1	0	0	0	13385	739	26	4	2164	4	RHBDF2	17	74475253	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	199093	74475253	6719957	1714	51603											
ST6GALNAC1	55808	broad.mit.edu	37	chr17	74621571	74621571	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatagtagtgatcagaaaaGcgctcatggccctcagtgat	12	10	10	9	1	4	3	4	2	0	1	4	3	4	3	1	1	1	2	1	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:74621571G>A	uc002jsh.2	-	9	1818	c.1644C>T	c.(1642-1644)CGC>CGT	p.R548R	ST6GALNAC1_uc002jsi.2_Silent_p.R416R|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	548	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						GATCAGAAAAGCGCTCATGGC	0.488													40	33					0	0	0	0	A	74621571	A	A	74621571	2	1	276	1	0	0	0	0	0	0	0	1	15289	958	34	4		4	ST6GALNAC1	17	74621571	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	146318	74621571	6573639	1715	51604											
SFRS2	6427	broad.mit.edu	37	chr17	74732409	74732409	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacttggacttggaccttCgtgcggatctggacttggag	7	11	15	8	2	1	0	0	0	1	0	2	6	1	6	1	6	1	0	1	6	0	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:74732409C>A	uc002jsv.2	-	2	670	c.500G>T	c.(499-501)CGA>CTA	p.R167L	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Missense_Mutation_p.R167L|SFRS2_uc010wtg.1_Missense_Mutation_p.R155L|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	167	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						CTTGGACCTTCGTGCGGATCT	0.622													21	92					2.27731e-05	2.30825e-05	1	0	A	74732409	A	A	74732409	3	1	276	1	0	0	0	0	1	0	0	0	14240	884	31	3	169	3	SFRS2	17	74732409	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	110838	74732409	6462801	1716	51605											
DNAH17	8632	broad.mit.edu	37	chr17	76447632	76447632	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtccatccctggtgaccagGaagttgatgagggtgcactg	9	9	14	9	0	0	3	0	3	0	0	2	4	2	4	3	3	1	2	3	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:76447632G>A	uc010dhp.1	-	11	1875	c.1653C>T	c.(1651-1653)TTC>TTT	p.F551F	DNAH17_uc002jvq.2_5'Flank|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGGTGACCAGGAAGTTGATGA	0.557													58	143					0	0	0	0	A	76447632	A	A	76447632	2	1	276	1	0	0	0	0	0	0	0	1	4623	1165	41	2		2	DNAH17	17	76447632	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1715223	76447632	4747578	1717	51606											
RNF213	57674	broad.mit.edu	37	chr17	78319833	78319833	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cctctgaggcagctggtataCcgggtccatgctctgccccc	5	9	11	16	1	2	1	0	1	2	0	3	1	3	1	5	3	4	4	5	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:78319833C>T	uc002jyh.1	+	4	2140	c.1917C>T	c.(1915-1917)TAC>TAT	p.Y639Y		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AGCTGGTATACCGGGTCCATG	0.557													11	42					0	0	0	0	T	78319833	T	T	78319833	2	4	276	1	0	0	0	0	0	0	0	1	13542	518	18	4		4	RNF213	17	78319833	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1872201	78319833	2875377	1718	51607											
RNF213	57674	broad.mit.edu	37	chr17	78332094	78332094	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttctgtgctgcaggcacacCctctggaagcgggtccaagg	7	8	13	13	1	2	0	0	0	2	0	3	1	3	1	2	4	3	3	2	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:78332094C>T	uc002jyh.1	+	12	5311	c.5088C>T	c.(5086-5088)ACC>ACT	p.T1696T	uc002jyi.1_Intron|RNF213_uc010dhw.1_Silent_p.T78T	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GCAGGCACACCCTCTGGAAGC	0.542													12	41					0	0	0	0	T	78332094	T	T	78332094	2	4	276	1	0	0	0	0	0	0	0	1	13542	610	22	4		4	RNF213	17	78332094	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	12261	78332094	2863116	1719	51608											
SLC38A10	124565	broad.mit.edu	37	chr17	79234188	79234188	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacgcccaggccgacccacaGcaccacctgaggagacaaag	13	1	11	16	2	0	2	0	1	0	1	0	5	0	2	5	2	1	1	5	2	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:79234188G>A	uc002jzz.1	-	11	1513	c.1138C>T	c.(1138-1140)CTG>TTG	p.L380L	SLC38A10_uc002jzy.1_Silent_p.L298L|SLC38A10_uc002kab.2_Silent_p.L380L	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	380	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CCGACCCACAGCACCACCTGA	0.677													6	13					0	0	0	0	A	79234188	A	A	79234188	2	1	276	1	0	0	0	0	0	0	0	1	14666	962	34	4		4	SLC38A10	17	79234188	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	902094	79234188	1961022	1720	51609											
ACTG1	71	broad.mit.edu	37	chr17	79477846	79477847	+	Missense_Mutation	DNP	GG	AA	AA																															acaccgagtacttgcgctctGggggtgcgatgatctgcaaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:79477846_79477847GG>AA	uc002kaj.1	-	5	1022_1023	c.997_998CC>TT	c.(997-999)CCA>TTA	p.P333L	ACTG1_uc002kah.1_Missense_Mutation_p.P211L|ACTG1_uc002kai.1_Missense_Mutation_p.P290L|ACTG1_uc002kak.1_Missense_Mutation_p.P333L|ACTG1_uc010wun.1_Missense_Mutation_p.P333L|ACTG1_uc002kal.1_Missense_Mutation_p.P333L|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	333					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			CTTGCGCTCTGGGGGTGCGATG	0.629													47	49					0	0	0	0	AA	79477847	AA	AA	79477846	3	1	276	1	0	0	0	0	1	0	0	0	196	1348	47	4	133	4	ACTG1	17	79477846	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	243658	79477846	1717364	1721	51610											
NPLOC4	55666	broad.mit.edu	37	chr17	79536083	79536083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccggttttcaataggaaatgGattttgcgaaatagaaaaag	16	11	10	4	2	1	1	1	0	0	1	1	4	1	3	1	3	1	1	1	3	7	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:79536083G>A	uc002kat.3	-	14	1590	c.1408C>T	c.(1408-1410)CCA>TCA	p.P470S	NPLOC4_uc002kau.3_Missense_Mutation_p.P470S|NPLOC4_uc010wur.1_Missense_Mutation_p.P309S|NPLOC4_uc010dic.2_5'Flank|NPLOC4_uc002kas.2_5'UTR	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	470					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			ATAGGAAATGGATTTTGCGAA	0.368													16	79					0	0	0	0	A	79536083	A	A	79536083	3	1	276	1	0	0	0	0	1	0	0	0	10640	1174	41	2	434	2	NPLOC4	17	79536083	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	58237	79536083	1659127	1722	51611											
TSPAN10	83882	broad.mit.edu	37	chr17	79612449	79612449	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacgtggcttctctgggggCatccttgccttcctggtgct	2	15	12	12	1	1	0	0	0	1	0	4	0	3	0	3	4	3	3	3	4	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:79612449C>T	uc010die.2	+	2	558	c.468C>T	c.(466-468)GGC>GGT	p.G156G	TSPAN10_uc002kaw.1_Silent_p.G156G|TSPAN10_uc010did.1_RNA	NM_031945	NP_114151	Q9H1Z9	TSN10_HUMAN	tetraspanin 10	156	Helical; (Potential).					integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TCTCTGGGGGCATCCTTGCCT	0.687													12	7					0	0	0	0	T	79612449	T	T	79612449	2	4	276	1	0	0	0	0	0	0	0	1	16701	697	25	4		4	TSPAN10	17	79612449	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	76366	79612449	1582761	1723	51612											
PYCR1	5831	broad.mit.edu	37	chr17	79892293	79892293	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggcatggatggtggcccCaccaggagagctgacgttgt	9	7	15	10	1	0	2	0	1	0	1	0	4	0	3	3	5	1	3	3	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:79892293C>T	uc002kcr.1	-	6	984	c.706G>A	c.(706-708)GGG>AGG	p.G236R	PYCR1_uc002kcq.1_Intron|PYCR1_uc002kcp.2_Missense_Mutation_p.G236R|PYCR1_uc002kcs.1_Intron|PYCR1_uc010wvd.1_Missense_Mutation_p.G263R|PYCR1_uc002kct.1_Missense_Mutation_p.G236R|PYCR1_uc002kcu.1_Missense_Mutation_p.G205R|PYCR1_uc010wve.1_Missense_Mutation_p.G157R	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	236					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	ATGGTGGCCCCACCAGGAGAG	0.642													8	32					0	0	0	0	T	79892293	T	T	79892293	3	4	276	1	0	0	0	0	1	0	0	0	12920	594	21	4	349	4	PYCR1	17	79892293	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	279844	79892293	1302917	1724	51613											
RAC3	5881	broad.mit.edu	37	chr17	79990328	79990328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttccccggagagtacatccCcaccgtgtgagtgtgggggc	6	8	14	13	2	0	2	0	1	0	1	2	3	2	2	5	3	1	1	5	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:79990328C>T	uc002kdf.2	+	2	207	c.101C>T	c.(100-102)CCC>CTC	p.P34L		NM_005052	NP_005043	P60763	RAC3_HUMAN	ras-related C3 botulinum toxin substrate 3 (rho	34	Effector region (Potential).				actin cytoskeleton organization|cell projection assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endomembrane system|filamentous actin|growth cone|lamellipodium|neuronal cell body|plasma membrane	GTP binding|GTPase activity|protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GAGTACATCCCCACCGTGTGA	0.677													24	31					0	0	0	0	T	79990328	T	T	79990328	3	4	276	1	0	0	0	0	1	0	0	0	13041	623	22	4	107	4	RAC3	17	79990328	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	98035	79990328	1204882	1725	51614											
DUS1L	64118	broad.mit.edu	37	chr17	80019150	80019150	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcaggggtgctcccgcacGatgtccagatactcctcggc	6	7	14	14	3	0	1	0	0	0	1	4	2	3	1	3	4	2	3	3	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:80019150G>A	uc002kdq.2	-	7	1196	c.777C>T	c.(775-777)ATC>ATT	p.I259I	DUS1L_uc002kdp.2_Silent_p.I128I|DUS1L_uc002kdr.2_Silent_p.I259I|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA|DUS1L_uc010wvi.1_Silent_p.I242I	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	259					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GCTCCCGCACGATGTCCAGAT	0.672													8	23					0	0	0	0	A	80019150	A	A	80019150	2	1	276	1	0	0	0	0	0	0	0	1	4827	1048	37	1		1	DUS1L	17	80019150	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	28822	80019150	1176060	1726	51615											
FASN	2194	broad.mit.edu	37	chr17	80046905	80046905	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgctcaggcacgtgccacagGgcctcctggaacagcacagg	9	5	13	14	1	1	0	1	0	0	0	2	1	2	1	3	4	4	3	3	4	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:80046905G>A	uc002kdu.2	-	14	2361	c.2244C>T	c.(2242-2244)GCC>GCT	p.A748A	FASN_uc002kdw.1_5'Flank	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	748	Acyl and malonyl transferases (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CGTGCCACAGGGCCTCCTGGA	0.697													9	9					0	0	0	0	A	80046905	A	A	80046905	2	1	276	1	0	0	0	0	0	0	0	1	5715	1219	43	4		4	FASN	17	80046905	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	27755	80046905	1148305	1727	51616											
FASN	2194	broad.mit.edu	37	chr17	80049491	80049491	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccgcccatccaacagcgctgGgatctcagggttggggctat	7	8	13	13	2	1	0	1	0	1	0	3	1	2	1	3	4	2	3	3	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:80049491G>A	uc002kdu.2	-	9	1216	c.1099C>T	c.(1099-1101)CCA>TCA	p.P367S	FASN_uc002kdw.1_5'Flank	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	367	Beta-ketoacyl synthase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	AACAGCGCTGGGATCTCAGGG	0.682													3	13					0	0	0	0	A	80049491	A	A	80049491	3	1	276	1	0	0	0	0	1	0	0	0	5715	1232	43	4	6576	4	FASN	17	80049491	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2586	80049491	1145719	1728	51617											
RAB40B	10966	broad.mit.edu	37	chr17	80622390	80622390	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accagagctgcagcttcaccCgccgcccgtccagcaggatg	8	5	11	17	3	1	1	1	0	0	1	2	2	2	2	5	1	4	4	5	1	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:80622390C>T	uc002kft.2	-	2	311	c.185G>A	c.(184-186)CGG>CAG	p.R62Q	RAB40B_uc002kfs.2_RNA	NM_006822	NP_006813	Q12829	RB40B_HUMAN	RAB40B, member RAS oncogene family	62					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			central_nervous_system(1)	1	Breast(20;0.00132)|all_neural(118;0.0952)	all_cancers(8;0.072)|all_epithelial(8;0.139)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			CAGCTTCACCCGCCGCCCGTC	0.642													31	111					0	0	0	0	T	80622390	T	T	80622390	3	4	276	1	0	0	0	0	1	0	0	0	13006	652	23	1	671	1	RAB40B	17	80622390	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	572899	80622390	572820	1729	51618											
FN3K	64122	broad.mit.edu	37	chr17	80708411	80708411	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cattatttacgacccggcttCcttctatggccattccgagt	7	14	7	13	3	1	0	0	0	1	0	3	2	3	0	4	2	1	1	4	2	3	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr17:80708411C>T	uc010wvs.1	+	6	771	c.710C>T	c.(709-711)TCC>TTC	p.S237F	TBCD_uc002kfx.1_5'Flank|TBCD_uc002kfy.1_5'Flank|TBCD_uc002kfz.2_5'Flank	NM_022158	NP_071441	Q9H479	FN3K_HUMAN	fructosamine 3 kinase	237					fructoselysine metabolic process		fructosamine-3-kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			GACCCGGCTTCCTTCTATGGC	0.572													39	201					0	0	0	0	T	80708411	T	T	80708411	3	4	276	1	0	0	0	0	1	0	0	0	5995	855	30	2	732	2	FN3K	17	80708411	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	86021	80708411	486799	1730	51619											
MYOM1	8736	broad.mit.edu	37	chr18	3187612	3187612	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcttcattcagcttggcAtgatatgtctcggtttcttc	5	18	9	9	1	5	1	2	1	3	0	7	1	5	1	0	3	1	3	0	3	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:3187612A>C	uc002klp.2	-	5	1129	c.795T>G	c.(793-795)CAT>CAG	p.H265Q	MYOM1_uc002klq.2_Missense_Mutation_p.H265Q	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	265						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TCAGCTTGGCATGATATGTCT	0.358													13	48					0	0	0	0	C	3187612	C	C	3187612	3	2	276	1	0	0	0	0	1	0	0	0	10144	214	8	5	4398	5	MYOM1	18	3187612	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08		3187612	74889636	1731	51620											
DLGAP1	9229	broad.mit.edu	37	chr18	3534553	3534553	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaattttccagattatcatgGaagtccaggtcggcctgtac	10	12	10	9	1	1	1	1	0	0	1	4	3	3	2	3	3	1	1	3	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:3534553G>A	uc002kmf.2	-	7	2185	c.2118C>T	c.(2116-2118)TTC>TTT	p.F706F	DLGAP1_uc010wyz.1_Silent_p.F706F|DLGAP1_uc002kme.1_Silent_p.F404F|DLGAP1_uc010dkn.2_Silent_p.F414F|DLGAP1_uc010wyw.1_Silent_p.F412F|DLGAP1_uc010wyx.1_Silent_p.F428F|DLGAP1_uc010wyy.1_Silent_p.F390F|DLGAP1_uc002kmg.2_Silent_p.F404F	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	706					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GATTATCATGGAAGTCCAGGT	0.483													11	34					0	0	0	0	A	3534553	A	A	3534553	2	1	276	1	0	0	0	0	0	0	0	1	4581	1165	41	2		2	DLGAP1	18	3534553	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	346941	3534553	74542695	1732	51621											
L3MBTL4	91133	broad.mit.edu	37	chr18	6239847	6239847	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccagcttcattccaacctGaaattctttagacattggcc	10	13	5	13	0	2	2	1	1	1	1	4	2	4	2	4	1	2	1	4	1	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:6239847G>A	uc002kmz.3	-	9	737	c.577C>T	c.(577-579)CAG>TAG	p.Q193*	L3MBTL4_uc010dkt.2_Nonsense_Mutation_p.Q193*|L3MBTL4_uc002kmy.3_Nonsense_Mutation_p.Q31*	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	193	MBT 2.				chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				ATTCCAACCTGAAATTCTTTA	0.468													8	46					0	0	0	0	A	6239847	A	A	6239847	4	1	276	1	0	0	0	0	0	1	0	0	8634	1299	45	2	1342	2	L3MBTL4	18	6239847	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2705294	6239847	71837401	1733	51622											
PTPRM	5797	broad.mit.edu	37	chr18	8376134	8376135	+	Missense_Mutation	DNP	GG	AA	AA																															accatgccaccggcctgctgGgattcgtgcggcaagtcaag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:8376134_8376135GG>AA	uc002knn.3	+	23	3726_3727	c.3223_3224GG>AA	c.(3223-3225)GGA>AAA	p.G1075K	PTPRM_uc010dkv.2_Missense_Mutation_p.G1088K|PTPRM_uc010wzl.1_Missense_Mutation_p.G862K	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1075	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CGGCCTGCTGGGATTCGTGCGG	0.589													9	54					0	0	0	0	AA	8376135	AA	AA	8376134	3	1	276	1	0	0	0	0	1	0	0	0	12871	1233	43	4	3360	4	PTPRM	18	8376134	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	2136287	8376134	69701114	1734	51623											
ANKRD12	23253	broad.mit.edu	37	chr18	9211708	9211708	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aactcctttacacatggctgCtattcgaggagatgtgaaac	12	11	9	9	1	0	2	0	1	0	1	2	4	1	2	1	2	4	2	1	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:9211708C>T	uc002knv.2	+	6	835	c.578C>T	c.(577-579)GCT>GTT	p.A193V	ANKRD12_uc010wzn.1_Missense_Mutation_p.A193V|ANKRD12_uc002knw.2_Missense_Mutation_p.A170V|ANKRD12_uc002knx.2_Missense_Mutation_p.A170V	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	193	ANK 1.					nucleus				ovary(2)|central_nervous_system(1)	3						CACATGGCTGCTATTCGAGGA	0.363													10	43					0	0	0	0	T	9211708	T	T	9211708	3	4	276	1	0	0	0	0	1	0	0	0	640	797	28	4	596	4	ANKRD12	18	9211708	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	835574	9211708	68865540	1735	51624											
ANKRD12	23253	broad.mit.edu	37	chr18	9258557	9258557	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagaaaaagacagtgaatcCtcatctcctagaggaagaat	17	8	8	8	0	3	5	2	1	1	4	5	6	4	6	2	1	0	0	2	1	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:9258557C>T	uc002knv.2	+	9	5549	c.5292C>T	c.(5290-5292)TCC>TCT	p.S1764S	ANKRD12_uc002knw.2_Silent_p.S1741S|ANKRD12_uc002knx.2_Silent_p.S1741S|ANKRD12_uc010dkx.1_Silent_p.S1471S	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1764						nucleus				ovary(2)|central_nervous_system(1)	3						ACAGTGAATCCTCATCTCCTA	0.398													8	27					0	0	0	0	T	9258557	T	T	9258557	2	4	276	1	0	0	0	0	0	0	0	1	640	668	24	4		4	ANKRD12	18	9258557	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	46849	9258557	68818691	1736	51625											
PPP4R1	9989	broad.mit.edu	37	chr18	9570373	9570373	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaatggaaggagttatacAattcctgatctaagagagct	16	10	10	5	0	1	3	0	1	1	2	2	6	2	5	1	2	2	2	1	2	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:9570373A>T	uc002koe.1	-	11	1473	c.1355T>A	c.(1354-1356)TTG>TAG	p.L452*	PPP4R1_uc002kof.2_5'UTR|PPP4R1_uc010wzo.1_Nonsense_Mutation_p.L298*|PPP4R1_uc002kod.1_Nonsense_Mutation_p.L435*|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	452					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						GGAGTTATACAATTCCTGATC	0.433													21	80					0	0	0	0	T	9570373	T	T	9570373	4	4	276	1	0	0	0	0	0	1	0	0	12463	131	5	5	1537	5	PPP4R1	18	9570373	Nonsense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	311816	9570373	68506875	1737	51626											
TXNDC2	84203	broad.mit.edu	37	chr18	9887690	9887690	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acccaaggagattgacatccCcaagtccccagaagaaacca	16	4	7	14	0	0	4	0	1	0	3	2	5	2	4	6	1	1	0	6	1	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:9887690C>T	uc002koi.3	+	2	1663	c.1214C>T	c.(1213-1215)CCC>CTC	p.P405L	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.P338L	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	405	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.|20.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						ATTGACATCCCCAAGTCCCCA	0.547													11	75					0	0	0	0	T	9887690	T	T	9887690	3	4	276	1	0	0	0	0	1	0	0	0	16865	623	22	4	1220	4	TXNDC2	18	9887690	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	317317	9887690	68189558	1738	51627											
MC2R	4158	broad.mit.edu	37	chr18	13884843	13884843	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagcagaagatgaagaccccGagcaggatggtcagtgtgat	13	6	14	8	1	1	5	1	2	0	3	1	7	1	6	2	2	2	2	2	2	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:13884843G>A	uc002ksp.1	-	2	852	c.675C>T	c.(673-675)CTC>CTT	p.L225L		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	225	Helical; Name=6; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	TGAAGACCCCGAGCAGGATGG	0.552													20	33					0	0	0	0	A	13884843	A	A	13884843	2	1	276	1	0	0	0	0	0	0	0	1	9417	1045	37	1		1	MC2R	18	13884843	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3997153	13884843	64192405	1739	51628											
CTAGE1	64693	broad.mit.edu	37	chr18	19995654	19995654	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgtggtggacctgggacatcCcttggagaaaaataatctgg	11	9	13	8	1	1	1	0	0	1	1	2	4	2	3	2	5	0	0	2	5	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:19995654C>T	uc002ktv.1	-	1	2225	c.2121G>A	c.(2119-2121)AGG>AGA	p.R707R		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	707	Pro-rich.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					CTGGGACATCCCTTGGAGAAA	0.507													18	74					0	0	0	0	T	19995654	T	T	19995654	2	4	276	1	0	0	0	0	0	0	0	1	4009	622	22	4		4	CTAGE1	18	19995654	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6110811	19995654	58081594	1740	51629											
C18orf45	85019	broad.mit.edu	37	chr18	21001409	21001409	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caccaatgagcgtctgccacCtggaaaggacaaggggcaat	13	5	12	11	1	1	1	0	1	1	0	1	3	1	3	3	4	2	1	3	4	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:21001409C>T	uc002kuf.2	-	3	229	c.120_splice	c.e3-1	p.G40_splice	C18orf45_uc010xaq.1_Splice_Site|C18orf45_uc010xar.1_Splice_Site|C18orf45_uc002kug.2_Splice_Site|C18orf45_uc002kuh.2_Intron	NM_032933	NP_116322	Q24JQ0	CR045_HUMAN	hypothetical protein LOC85019							integral to membrane					0	all_cancers(21;0.000238)|all_epithelial(16;5.29e-06)|Lung NSC(20;0.00925)|Colorectal(14;0.0202)|all_lung(20;0.0255)|Ovarian(20;0.127)					CGTCTGCCACCTGGAAAGGAC	0.493													8	31					0	0	0	0	T	21001409	T	T	21001409	5	4	276	1	0	0	0	0	0	0	1	0	1912	695	24	4	823	4	C18orf45	18	21001409	Splice_Site	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1005755	21001409	57075839	1741	51630											
LAMA3	3909	broad.mit.edu	37	chr18	21395193	21395193	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacagtgagtggaactggaGagtgtaggcaggtaaagtgg	13	7	18	3	0	0	2	0	1	0	1	0	5	0	3	0	5	2	3	0	5	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:21395193G>A	uc002kuq.2	+	16	2016	c.1930G>A	c.(1930-1932)GAG>AAG	p.E644K	LAMA3_uc002kur.2_Missense_Mutation_p.E644K	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	644	Domain V.|Laminin EGF-like 7.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGAACTGGAGAGTGTAGGCA	0.493													5	13					0	0	0	0	A	21395193	A	A	21395193	3	1	276	1	0	0	0	0	1	0	0	0	8647	943	33	2	1992	2	LAMA3	18	21395193	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	393784	21395193	56682055	1742	51631											
CDH2	1000	broad.mit.edu	37	chr18	25570168	25570168	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatcttaggattgggggcAaaataagggttttcatttac	12	14	11	4	0	2	1	1	1	1	0	2	2	2	2	0	4	1	2	0	4	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:25570168A>G	uc002kwg.2	-	10	1950	c.1491T>C	c.(1489-1491)TTT>TTC	p.F497F	CDH2_uc010xbn.1_Silent_p.F466F	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	497	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GATTGGGGGCAAAATAAGGGT	0.458													18	59					0	0	0	0	G	25570168	G	G	25570168	2	3	276	1	0	0	0	0	0	0	0	1	3120	127	5	5		5	CDH2	18	25570168	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	4174975	25570168	52507080	1743	51632											
RNF138	51444	broad.mit.edu	37	chr18	29706662	29706662	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tctgtttcttatagacatgtCctatttgtgtgtctcttcct	5	21	6	9	0	3	1	0	0	3	1	6	1	5	1	2	0	0	1	2	0	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:29706662C>T	uc002kxg.2	+	7	1007	c.568C>T	c.(568-570)CCT>TCT	p.P190S	RNF138_uc002kxh.2_Missense_Mutation_p.P96S	NM_016271	NP_057355	Q8WVD3	RN138_HUMAN	ring finger protein 138 isoform 1	190					Wnt receptor signaling pathway	intracellular	ligase activity|protein kinase binding|zinc ion binding				0						ATAGACATGTCCTATTTGTGT	0.299													15	50					0	0	0	0	T	29706662	T	T	29706662	3	4	276	1	0	0	0	0	1	0	0	0	13506	855	30	2	590	2	RNF138	18	29706662	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4136494	29706662	48370586	1744	51633											
ASXL3	80816	broad.mit.edu	37	chr18	31319226	31319226	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttcttctgagagcccagagGgagcctgtaccagcctgcct	7	10	11	13	0	2	2	0	1	2	2	2	4	2	3	5	1	5	1	5	1	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:31319226G>A	uc010dmg.1	+	11	1913	c.1858G>A	c.(1858-1860)GGA>AGA	p.G620R	ASXL3_uc002kxq.2_Missense_Mutation_p.G327R	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	620	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GAGCCCAGAGGGAGCCTGTAC	0.483													6	13					0	0	0	0	A	31319226	A	A	31319226	3	1	276	1	0	0	0	0	1	0	0	0	1070	1233	43	4	1900	4	ASXL3	18	31319226	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1612564	31319226	46758022	1745	51634											
NOL4	8715	broad.mit.edu	37	chr18	31432930	31432930	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttggactcagctggggtCtggagtttgagctgctggag	6	11	17	7	0	2	1	1	1	1	0	2	4	2	4	0	5	3	5	0	5	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:31432930C>T	uc010dmi.2	-	11	2022	c.1793G>A	c.(1792-1794)AGA>AAA	p.R598K	NOL4_uc010xbs.1_Missense_Mutation_p.R313K|NOL4_uc002kxr.3_Missense_Mutation_p.R370K|NOL4_uc010xbt.1_Missense_Mutation_p.R524K|NOL4_uc010dmh.2_Missense_Mutation_p.R460K|NOL4_uc010xbu.1_Missense_Mutation_p.R534K|NOL4_uc002kxt.3_Missense_Mutation_p.R496K	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	598						nucleolus	RNA binding			ovary(3)	3						CAGCTGGGGTCTGGAGTTTGA	0.453													13	44					0	0	0	0	T	31432930	T	T	31432930	3	4	276	1	0	0	0	0	1	0	0	0	10578	913	32	2	127	2	NOL4	18	31432930	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	113704	31432930	46644318	1746	51635											
SLC39A6	25800	broad.mit.edu	37	chr18	33704511	33704511	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aatgaataggtctttggaggGatttcagccttcttttcact	9	16	9	7	0	4	1	2	1	2	0	4	3	4	3	1	3	1	0	1	3	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:33704511G>A	uc010dmy.2	-	3	1232	c.942C>T	c.(940-942)ATC>ATT	p.I314I	SLC39A6_uc002kzj.2_Silent_p.I39I	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	314	Extracellular (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						TCTTTGGAGGGATTTCAGCCT	0.343													15	62					0	0	0	0	A	33704511	A	A	33704511	2	1	276	1	0	0	0	0	0	0	0	1	14686	1164	41	2		2	SLC39A6	18	33704511	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2271581	33704511	44372737	1747	51636											
KIAA1632	57724	broad.mit.edu	37	chr18	43460176	43460176	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacactcggggctcagaagcTgctccgcggagcctgccagc	8	5	13	15	3	1	1	1	0	0	1	3	2	2	2	3	3	6	3	3	3	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:43460176T>A	uc002lbm.2	-	32	5631	c.5531A>T	c.(5530-5532)CAG>CTG	p.Q1844L	KIAA1632_uc010xcq.1_Missense_Mutation_p.Q398L|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.Q719L	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1844					autophagy						0						GCTCAGAAGCTGCTCCGCGGA	0.587											OREG0024951	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	14					0	0	0	0	A	43460176	A	A	43460176	3	1	276	1	0	0	0	0	1	0	0	0	8288	1580	55	5	2260	5	KIAA1632	18	43460176	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	9755665	43460176	34617072	1748	51637											
KIAA1632	57724	broad.mit.edu	37	chr18	43464702	43464703	+	Missense_Mutation	DNP	GG	AA	AA																															gtgaagaaaggagacagcagGgagcagagcctgctgttctt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:43464702_43464703GG>AA	uc002lbm.2	-	30	5283_5284	c.5183_5184CC>TT	c.(5182-5184)TCC>TTT	p.S1728F	KIAA1632_uc010xcq.1_Missense_Mutation_p.S282F|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.S603F	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1728					autophagy						0						GAGACAGCAGGGAGCAGAGCCT	0.416													15	29					0	0	0	0	AA	43464703	AA	AA	43464702	3	1	276	1	0	0	0	0	1	0	0	0	8288	1219	43	4	2615	4	KIAA1632	18	43464702	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	4526	43464702	34612546	1749	51638											
TCEB3B	51224	broad.mit.edu	37	chr18	44561204	44561204	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctcgcgactgtgagacctCgggtgaggtctctgttgccc	4	10	15	12	3	1	2	0	2	1	1	4	4	1	2	2	3	1	2	2	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:44561204C>T	uc002lcr.1	-	1	785	c.432G>A	c.(430-432)CCG>CCA	p.P144P	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	144					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TGTGAGACCTCGGGTGAGGTC	0.647													15	75					0	0	0	0	T	44561204	T	T	44561204	2	4	276	1	0	0	0	0	0	0	0	1	15748	871	31	1		1	TCEB3B	18	44561204	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1096502	44561204	33516044	1750	51639											
KATNAL2	83473	broad.mit.edu	37	chr18	44595966	44595966	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggggattcagaaaaactcGttcgggtaggaattcttaat	13	11	12	5	2	2	1	1	0	1	1	4	4	2	3	0	4	1	2	0	4	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:44595966G>A	uc002lco.2	+	10	981	c.787G>A	c.(787-789)GTT>ATT	p.V263I	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lcp.3_Missense_Mutation_p.V190I	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	335						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						AGAAAAACTCGTTCGGGTAGG	0.358													11	38					0	0	0	0	A	44595966	A	A	44595966	3	1	276	1	0	0	0	0	1	0	0	0	8025	1145	40	1	821	1	KATNAL2	18	44595966	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	34762	44595966	33481282	1751	51640											
MYO5B	4645	broad.mit.edu	37	chr18	47376030	47376030	+	Frame_Shift_Del	DEL	C	-	-																															ttctaccagttctttaaggtCctggaagcagaggaagcagt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:47376030delC	uc002leb.2	-	32	4510	c.4222delG	c.(4222-4224)GACfs	p.D1408fs	MYO5B_uc002ldz.2_5'UTR|MYO5B_uc002lea.2_Frame_Shift_Del_p.D523fs	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1408	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TCTTTAAGGTCCTGGAAGCAG	0.507													---	---	---								-	47376030	-	-	47376030	7	5	276	1	0	1	0	1	0	0	0	0	10132	869	30	0	1360	0	MYO5B	18	47376030	Frame_Shift_Del	DEL	C	TCGA-D6-6516-01A-11D-1870-08	2780064	47376030	30701218	1752	51641											
DCC	1630	broad.mit.edu	37	chr18	50866165	50866165	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgagttggactcctcccttGaacccaaacatcgtggtgcg	9	10	10	12	2	0	2	0	2	0	0	3	3	2	3	3	2	3	1	3	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:50866165G>A	uc002lfe.1	+	15	2834	c.2247G>A	c.(2245-2247)TTG>TTA	p.L749L	DCC_uc010xdr.1_Silent_p.L597L|DCC_uc010dpf.1_Silent_p.L404L	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	749	Extracellular (Potential).|Fibronectin type-III 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTCCTCCCTTGAACCCAAACA	0.483													21	62					0	0	0	0	A	50866165	A	A	50866165	2	1	276	1	0	0	0	0	0	0	0	1	4299	1281	45	2		2	DCC	18	50866165	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3490135	50866165	27211083	1753	51642											
ALPK2	115701	broad.mit.edu	37	chr18	56246869	56246869	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccgagacccacaacccattCcactgaggaaatgctcacac	13	5	6	17	1	1	2	1	1	0	1	2	4	2	3	4	1	2	1	4	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:56246869C>T	uc002lhj.3	-	4	1353	c.1139G>A	c.(1138-1140)GGA>GAA	p.G380E		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	380							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						ACAACCCATTCCACTGAGGAA	0.537											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	16					0	0	0	0	T	56246869	T	T	56246869	3	4	276	1	0	0	0	0	1	0	0	0	545	855	30	2	5413	2	ALPK2	18	56246869	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5380704	56246869	21830379	1754	51643											
CPLX4	339302	broad.mit.edu	37	chr18	56985658	56985659	+	Missense_Mutation	DNP	CC	TT	TT																															accaaatcctaaattctttaCctggttacttatcatacttt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:56985658_56985659CC>TT	uc002lhy.2	-	1	223_224	c.36_37GG>AA	c.(34-39)CAGGTA>CAAATA	p.V13I		NM_181654	NP_857637	Q7Z7G2	CPLX4_HUMAN	complexin 4 precursor	13					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			ovary(1)	1		Colorectal(73;0.175)				AAATTCTTTACCTGGTTACTTA	0.371													13	50					0	0	0	0	TT	56985659	TT	TT	56985658	3	4	276	1	0	0	0	0	1	0	0	0	3822	507	18	4	457	4	CPLX4	18	56985658	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	738789	56985658	21091590	1755	51644											
KIAA1468	57614	broad.mit.edu	37	chr18	59912005	59912005	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtatttctttaggagttgatCcccctcatattgtgtacagc	8	16	8	9	0	2	1	1	1	1	0	3	2	3	2	2	1	2	3	2	1	4	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:59912005C>T	uc002lil.2	+	11	1844	c.1629C>T	c.(1627-1629)ATC>ATT	p.I543I	KIAA1468_uc002lik.1_Silent_p.I543I|KIAA1468_uc010xel.1_Silent_p.I543I|KIAA1468_uc002lim.2_Silent_p.I187I	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	543							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				AGGAGTTGATCCCCCTCATAT	0.373													16	41					0	0	0	0	T	59912005	T	T	59912005	2	4	276	1	0	0	0	0	0	0	0	1	8275	845	30	2		2	KIAA1468	18	59912005	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2926347	59912005	18165243	1756	51645											
BCL2	596	broad.mit.edu	37	chr18	60795881	60795881	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgtggcccagataggcacCcagggtgatgcaagctccca	9	7	12	13	0	0	2	0	1	0	1	1	2	1	2	3	3	2	3	3	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:60795881C>T	uc002lit.1	-	3	1190	c.697G>A	c.(697-699)GGT>AGT	p.G233S	BCL2_uc002liu.1_Missense_Mutation_p.G233S	NM_000633	NP_000624	P10415	BCL2_HUMAN	B-cell lymphoma protein 2 alpha isoform	233	Helical; (Potential).				activation of pro-apoptotic gene products|anti-apoptosis|apoptosis in response to endoplasmic reticulum stress|B cell proliferation|B cell receptor signaling pathway|defense response to virus|female pregnancy|humoral immune response|induction of apoptosis by intracellular signals|negative regulation of cellular pH reduction|negative regulation of mitochondrial depolarization|negative regulation of neuron apoptosis|neuron apoptosis|positive regulation of B cell proliferation|positive regulation of cell growth|protein polyubiquitination|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|regulation of transmembrane transporter activity|release of cytochrome c from mitochondria|response to cytokine stimulus|response to DNA damage stimulus|response to drug|response to iron ion|response to nicotine|response to toxin	endoplasmic reticulum membrane|mitochondrial outer membrane|nuclear membrane|pore complex	BH3 domain binding|channel activity|protease binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)	1		all_hematologic(56;1.18e-20)|Prostate(75;0.0872)		Lung(128;0.0234)|READ - Rectum adenocarcinoma(59;0.0935)	Docetaxel(DB01248)|Fludarabine(DB01073)|Melatonin(DB01065)|Paclitaxel(DB01229)|Rasagiline(DB01367)	AGATAGGCACCCAGGGTGATG	0.502			T	IGH@	NHL|CLL								10	33					0	0	0	0	T	60795881	T	T	60795881	3	4	276	1	0	0	0	0	1	0	0	0	1367	623	22	4	26	4	BCL2	18	60795881	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	883876	60795881	17281367	1757	51646											
ZNF516	9658	broad.mit.edu	37	chr18	74154069	74154069	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgttgttgatggtggcgatGgggtccagctcactcttggg	5	12	16	8	2	2	1	1	1	1	0	3	2	3	1	1	5	1	3	1	5	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:74154069G>A	uc010dqx.1	-	2	1177	c.942C>T	c.(940-942)CCC>CCT	p.P314P	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		TGGTGGCGATGGGGTCCAGCT	0.617													7	41					0	0	0	0	A	74154069	A	A	74154069	2	1	276	1	0	0	0	0	0	0	0	1	18027	1335	47	4		4	ZNF516	18	74154069	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	13358188	74154069	3923179	1758	51647											
CTDP1	9150	broad.mit.edu	37	chr18	77464883	77464883	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacgagctgcacgtcttcacCttcggcagccggctgtacgc	6	9	11	15	5	2	0	1	0	1	0	3	1	2	0	2	2	5	5	2	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr18:77464883C>T	uc002lnh.1	+	5	885	c.738C>T	c.(736-738)ACC>ACT	p.T246T	CTDP1_uc002lni.1_Silent_p.T246T|CTDP1_uc010drd.1_Silent_p.T246T	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	246	FCP1 homology.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		ACGTCTTCACCTTCGGCAGCC	0.607													10	35					0	0	0	0	T	77464883	T	T	77464883	2	4	276	1	0	0	0	0	0	0	0	1	4019	668	24	4		4	CTDP1	18	77464883	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3310814	77464883	612365	1759	51648											
SHC2	25759	broad.mit.edu	37	chr19	419011	419011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgttctgcaggtggtggtCgatcaggtggctgatgctct	4	12	15	10	2	3	1	1	1	2	0	4	2	3	1	1	5	2	4	1	5	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:419011C>T	uc002loq.3	-	12	1666	c.1666G>A	c.(1666-1668)GAC>AAC	p.D556N	SHC2_uc002lop.3_Missense_Mutation_p.D297N	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	556	SH2.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTGGTGGTCGATCAGGTGG	0.672													4	2					0	0	0	0	T	419011	T	T	419011	3	4	276	1	0	0	0	0	1	0	0	0	14336	884	31	1	86	1	SHC2	19	419011	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08		419011	58709972	1760	51649											
PTBP1	5725	broad.mit.edu	37	chr19	806556	806556	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcagcaacctcaacccagaGgtacgtgggcttttcctccg	8	9	10	14	2	2	1	2	0	0	1	4	1	4	1	4	2	4	3	4	2	3	3	rs150400507	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:806556G>A	uc002lpr.2	+	9	1147	c.1041G>A	c.(1039-1041)GAG>GAA	p.E347E	PTBP1_uc002lpp.2_Silent_p.E373E|PTBP1_uc002lpq.2_Silent_p.E366E|PTBP1_uc002lps.2_Intron|PTBP1_uc002lpt.2_RNA|PTBP1_uc002lpu.1_Silent_p.E343E	NM_031991	NP_114368	P26599	PTBP1_HUMAN	polypyrimidine tract-binding protein 1 isoform	347	RRM 3.				negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			kidney(1)|skin(1)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAACCCAGAGGTACGTGGGC	0.701													4	8					0	0	0	0	A	806556	A	A	806556	2	1	276	1	0	0	0	0	0	0	0	1	12787	1014	35	4		4	PTBP1	19	806556	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	387545	806556	58322427	1761	51650											
ABCA7	10347	broad.mit.edu	37	chr19	1049288	1049288	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtagaagaggcaccgcccGgcctgagtcctggcgtctcc	6	7	14	14	3	1	3	0	1	1	2	3	3	2	3	5	4	0	2	5	4	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:1049288G>A	uc002lqw.3	+	18	2635	c.2404G>A	c.(2404-2406)GGC>AGC	p.G802S	ABCA7_uc010dsb.1_Missense_Mutation_p.G664S	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	802					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCACCGCCCGGCCTGAGTCC	0.667													21	44					0	0	0	0	A	1049288	A	A	1049288	3	1	276	1	0	0	0	0	1	0	0	0	37	1116	39	1	2470	1	ABCA7	19	1049288	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	242732	1049288	58079695	1762	51651											
ABCA7	10347	broad.mit.edu	37	chr19	1056930	1056930	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctcctcggtggacgtcctCgtctccatctgtgtggtctt	2	14	11	14	3	3	0	0	0	3	0	8	1	5	1	4	3	0	0	4	3	0	1	rs146414455		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:1056930C>T	uc002lqw.3	+	34	4842	c.4611C>T	c.(4609-4611)CTC>CTT	p.L1537L	ABCA7_uc002lqy.2_Silent_p.L8L|ABCA7_uc010dsc.2_5'Flank	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1537	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGACGTCCTCGTCTCCATCT	0.577													25	58					0	0	0	0	T	1056930	T	T	1056930	2	4	276	1	0	0	0	0	0	0	0	1	37	871	31	1		1	ABCA7	19	1056930	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	7642	1056930	58072053	1763	51652											
BTBD2	55643	broad.mit.edu	37	chr19	1987221	1987221	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggatccatacagcccaaatcCcaccacgaagatgcgcttgt	12	7	8	14	2	0	1	0	0	0	1	2	3	2	2	4	1	3	1	4	1	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:1987221C>T	uc002lup.1	-	7	1213	c.1213G>A	c.(1213-1215)GGA>AGA	p.G405R	BTBD2_uc002luo.1_Missense_Mutation_p.G84R	NM_017797	NP_060267	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	405						cytoplasmic mRNA processing body	protein binding			ovary(1)|skin(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCCCAAATCCCACCACGAAG	0.597													6	36					0	0	0	0	T	1987221	T	T	1987221	3	4	276	1	0	0	0	0	1	0	0	0	1548	632	22	4	376	4	BTBD2	19	1987221	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	930291	1987221	57141762	1764	51653											
C19orf36	113177	broad.mit.edu	37	chr19	2096977	2096977	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcctggtgtgcctgacGgcggcgctggcccacggctg	2	8	17	14	4	0	1	0	1	0	0	0	1	0	1	3	5	2	2	3	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:2096977G>T	uc002luw.1	+	1	110	c.33G>T	c.(31-33)ACG>ACT	p.T11T	C19orf36_uc002lux.1_Silent_p.T11T|C19orf36_uc010xgw.1_Silent_p.T11T|MOBKL2A_uc002luv.2_5'Flank	NM_001039846	NP_001034935	Q1ZYL8	IZUM4_HUMAN	hypothetical protein LOC113177 isoform 3	11						extracellular region					0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCCTGACGGCGGCGCTGG	0.672											OREG0025135	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	50					5.3912e-06	5.47322e-06	1	0	T	2096977	T	T	2096977	2	4	276	1	0	0	0	0	0	0	0	1	1930	1103	39	3		3	C19orf36	19	2096977	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	109756	2096977	57032006	1765	51654											
APBA3	9546	broad.mit.edu	37	chr19	3760025	3760025	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggcaatgtgtaggggacaggGggctccacctggggatgggc	7	6	20	8	0	0	0	0	0	0	0	1	2	1	2	2	8	0	3	2	8	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:3760025G>A	uc002lyp.1	-	2	415	c.238C>T	c.(238-240)CCC>TCC	p.P80S	MRPL54_uc002lyq.3_5'Flank	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	80					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGGACAGGGGGCTCCACCT	0.627													10	34					0	0	0	0	A	3760025	A	A	3760025	3	1	276	1	0	0	0	0	1	0	0	0	758	1232	43	4	1529	4	APBA3	19	3760025	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1663048	3760025	55368958	1766	51655											
DAPK3	1613	broad.mit.edu	37	chr19	3964694	3964694	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgtccaggatctgcttgaGgaactgggtggcctcgtcct	5	10	14	12	2	1	1	0	1	1	0	4	3	3	3	4	4	2	1	4	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:3964694G>A	uc002lzc.1	-	2	451	c.358C>T	c.(358-360)CTC>TTC	p.L120F	DAPK3_uc002lzb.1_5'Flank|DAPK3_uc002lzd.1_Missense_Mutation_p.L120F	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	120	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCTGCTTGAGGAACTGGGTG	0.632													13	93					0	0	0	0	A	3964694	A	A	3964694	3	1	276	1	0	0	0	0	1	0	0	0	4254	1000	35	4	1034	4	DAPK3	19	3964694	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	204669	3964694	55164289	1767	51656											
EEF2	1938	broad.mit.edu	37	chr19	3977901	3977901	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccttggtgatgtcggtgagGatgttggggccggtgccgtc	3	11	18	9	3	0	2	0	2	0	0	2	3	0	3	3	6	1	1	3	6	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:3977901G>A	uc002lze.2	-	12	2066	c.1983C>T	c.(1981-1983)ATC>ATT	p.I661I		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	661						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTCGGTGAGGATGTTGGGGC	0.642													16	63					0	0	0	0	A	3977901	A	A	3977901	2	1	276	1	0	0	0	0	0	0	0	1	4951	1164	41	2		2	EEF2	19	3977901	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	13207	3977901	55151082	1768	51657											
PIAS4	51588	broad.mit.edu	37	chr19	4037787	4037787	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cggaggatgaggaggaggagGaagaggaggaggaagacgag	15	1	23	2	2	0	3	0	1	0	2	0	13	0	12	0	9	0	0	0	9	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:4037787G>A	uc002lzg.2	+	11	1457	c.1447G>A	c.(1447-1449)GAA>AAA	p.E483K		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	483	Asp/Glu-rich (acidic).				positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		ggaggaggaggaagaggagga	0.552													5	10					0	0	0	0	A	4037787	A	A	4037787	3	1	276	1	0	0	0	0	1	0	0	0	11933	1175	41	2	1489	2	PIAS4	19	4037787	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	59886	4037787	55091196	1769	51658											
CREB3L3	84699	broad.mit.edu	37	chr19	4155015	4155015	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcgagggctggggtcacgtCaaggaccaggtgaggagtcc	8	5	19	9	2	2	1	2	1	0	0	3	4	3	3	2	7	0	1	2	7	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:4155015C>T	uc002lzl.2	+	2	263	c.147C>T	c.(145-147)GTC>GTT	p.V49V	CREB3L3_uc002lzm.2_Silent_p.V40V|CREB3L3_uc010xib.1_Silent_p.V40V|CREB3L3_uc010xic.1_Silent_p.V40V	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	49	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGTCACGTCAAGGACCAGG	0.652													15	65					0	0	0	0	T	4155015	T	T	4155015	2	4	276	1	0	0	0	0	0	0	0	1	3873	813	29	2		2	CREB3L3	19	4155015	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	117228	4155015	54973968	1770	51659											
LRG1	116844	broad.mit.edu	37	chr19	4538433	4538433	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggtcaagggtgcgcaggaggGtgaagttggccagcagcccg	8	5	19	9	2	1	1	1	1	0	0	1	2	1	2	2	5	3	3	2	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:4538433G>A	uc002mau.2	-	2	574	c.563C>T	c.(562-564)ACC>ATC	p.T188I	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	188						extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCAGGAGGGTGAAGTTGGC	0.622													46	149					0	0	0	0	A	4538433	A	A	4538433	3	1	276	1	0	0	0	0	1	0	0	0	8992	1261	44	4	484	4	LRG1	19	4538433	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	383418	4538433	54590550	1771	51660											
DPP9	91039	broad.mit.edu	37	chr19	4697574	4697574	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gacactcactatttgccatcCcgggtccacccggccctggc	6	8	9	18	2	1	0	1	0	0	0	3	1	3	0	5	3	1	0	5	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:4697574C>T	uc002mba.2	-	11	1422	c.1164G>A	c.(1162-1164)CGG>CGA	p.R388R	DPP9_uc002mbb.2_Silent_p.R388R|DPP9_uc002mbc.2_Silent_p.R388R	NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	359					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		ATTTGCCATCCCGGGTCCACC	0.632													6	24					0	0	0	0	T	4697574	T	T	4697574	2	4	276	1	0	0	0	0	0	0	0	1	4755	610	22	4		4	DPP9	19	4697574	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	159141	4697574	54431409	1772	51661											
PTPRS	5802	broad.mit.edu	37	chr19	5220306	5220306	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtcctctgggctacccagcgGggtcaggaattggcctccac	6	8	13	14	1	2	0	1	0	1	0	4	1	4	1	4	5	2	1	4	5	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:5220306G>A	uc002mbv.2	-	21	3748	c.3514C>T	c.(3514-3516)CCG>TCG	p.P1172S	PTPRS_uc002mbu.1_Missense_Mutation_p.P741S|PTPRS_uc010xin.1_Missense_Mutation_p.P741S|PTPRS_uc002mbw.2_Missense_Mutation_p.P1150S|PTPRS_uc002mbx.2_Missense_Mutation_p.P745S|PTPRS_uc002mby.2_Missense_Mutation_p.P741S	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1172	Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CTACCCAGCGGGGTCAGGAAT	0.587													5	21					0	0	0	0	A	5220306	A	A	5220306	3	1	276	1	0	0	0	0	1	0	0	0	12876	1232	43	4	2404	4	PTPRS	19	5220306	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	522732	5220306	53908677	1773	51662											
CLEC4M	10332	broad.mit.edu	37	chr19	7830111	7830111	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgctgcaactcctctcCttcatgctcttggctggggt	3	14	11	13	0	3	0	1	0	2	0	5	0	4	0	2	4	4	4	2	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:7830111C>T	uc002mih.2	+	3	289	c.171C>T	c.(169-171)TCC>TCT	p.S57S	CLEC4M_uc010xjv.1_Intron|CLEC4M_uc002mhy.2_Intron|CLEC4M_uc010xjw.1_Intron|CLEC4M_uc010dvt.2_Silent_p.S57S|CLEC4M_uc010dvs.2_Silent_p.S56S|CLEC4M_uc010xjx.1_Silent_p.S29S|CLEC4M_uc002mhz.2_Silent_p.S57S|CLEC4M_uc002mic.2_Silent_p.S29S|CLEC4M_uc002mia.2_Intron	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	57	Helical; Signal-anchor for type II membrane protein; (Probable).				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						AACTCCTCTCCTTCATGCTCT	0.622													22	53					0	0	0	0	T	7830111	T	T	7830111	2	4	276	1	0	0	0	0	0	0	0	1	3533	668	24	4		4	CLEC4M	19	7830111	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2609805	7830111	51298872	1774	51663											
HNRNPM	4670	broad.mit.edu	37	chr19	8550506	8550507	+	Missense_Mutation	DNP	CC	TT	TT																															ggtggaggtggaggaagcgtCcctgggatcgagaggatggg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:8550506_8550507CC>TT	uc010dwe.2	+	14	1274_1275	c.1194_1195CC>TT	c.(1192-1197)GTCCCT>GTTTCT	p.P399S	HNRNPM_uc010xke.1_Missense_Mutation_p.P345S|HNRNPM_uc010dwd.2_Missense_Mutation_p.P360S|HNRNPM_uc002mka.2_Missense_Mutation_p.P264S|HNRNPM_uc002mkb.1_5'Flank	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	399					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						GAGGAAGCGTCCCTGGGATCGA	0.634													23	95					0	0	0	0	TT	8550507	TT	TT	8550506	3	4	276	1	0	0	0	0	1	0	0	0	7310	842	30	2	1248	2	HNRNPM	19	8550506	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	720395	8550506	50578477	1775	51664											
MUC16	94025	broad.mit.edu	37	chr19	9068060	9068060	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggttgtgattgatgtgtcCcaggtaagggtaccctgtga	8	12	15	6	0	0	3	0	3	0	0	1	4	1	3	2	3	1	3	2	3	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:9068060C>T	uc002mkp.2	-	3	19590	c.19386G>A	c.(19384-19386)TGG>TGA	p.W6462*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6464	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGATGTGTCCCAGGTAAGGG	0.483													39	119					0	0	0	0	T	9068060	T	T	9068060	4	4	276	1	0	0	0	0	0	1	0	0	10026	624	22	4	24465	4	MUC16	19	9068060	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	517554	9068060	50060923	1776	51665											
MUC16	94025	broad.mit.edu	37	chr19	9072091	9072091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcttctgtgtttatagaagGaaaaatttcctttgtgtctt	9	19	7	6	0	3	1	0	0	3	1	4	2	4	2	1	1	0	1	1	1	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:9072091G>A	uc002mkp.2	-	3	15559	c.15355C>T	c.(15355-15357)CCT>TCT	p.P5119S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5121	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTTATAGAAGGAAAAATTTCC	0.453													28	74					0	0	0	0	A	9072091	A	A	9072091	3	1	276	1	0	0	0	0	1	0	0	0	10026	1174	41	2	28496	2	MUC16	19	9072091	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4031	9072091	50056892	1777	51666											
MUC16	94025	broad.mit.edu	37	chr19	9090942	9090942	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctctgatattttattatcGagaactgaagcagatgatga	13	14	9	5	1	1	6	0	4	1	2	3	7	1	6	0	0	2	1	0	0	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:9090942G>T	uc002mkp.2	-	1	1077	c.873C>A	c.(871-873)CTC>CTA	p.L291L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	291	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTTTATTATCGAGAACTGAAG	0.517													51	72					8.78508e-14	9.04913e-14	1	0	T	9090942	T	T	9090942	2	4	276	1	0	0	0	0	0	0	0	1	10026	1045	37	3		3	MUC16	19	9090942	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	18851	9090942	50038041	1778	51667											
ZNF559	84527	broad.mit.edu	37	chr19	9453078	9453078	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaactcaacattcacataagGgttcacactggagaaaaacc	18	7	6	10	0	3	1	3	0	0	1	3	2	3	1	1	2	3	1	1	2	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:9453078G>A	uc002mlg.2	+	7	1598	c.951G>A	c.(949-951)AGG>AGA	p.R317R	ZNF559_uc002mlf.2_Silent_p.R86R|ZNF559_uc010dwl.1_Silent_p.R86R|ZNF559_uc010xkn.1_Silent_p.R309R|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Silent_p.R381R|ZNF559_uc010dwk.1_Silent_p.R86R|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	317	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTCACATAAGGGTTCACACTG	0.368													6	53					0	0	0	0	A	9453078	A	A	9453078	2	1	276	1	0	0	0	0	0	0	0	1	18057	1223	43	4		4	ZNF559	19	9453078	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	362136	9453078	49675905	1779	51668											
ZNF177	7730	broad.mit.edu	37	chr19	9489658	9489658	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aactcagtaaccttccaggaAgtggcagtggacttttccca	11	10	9	11	0	1	0	1	0	0	0	3	2	3	2	3	3	2	2	3	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:9489658A>G	uc002mli.2	+	9	717	c.54A>G	c.(52-54)GAA>GAG	p.E18E	ZNF177_uc002mlj.2_5'UTR|ZNF177_uc002mlk.2_Silent_p.E18E	NM_003451	NP_003442	Q13360	ZN177_HUMAN	zinc finger protein 177	18	KRAB.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCTTCCAGGAAGTGGCAGTGG	0.463													20	99					0	0	0	0	G	9489658	G	G	9489658	2	3	276	1	0	0	0	0	0	0	0	1	17813	69	3	5		5	ZNF177	19	9489658	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	36580	9489658	49639325	1780	51669											
COL5A3	50509	broad.mit.edu	37	chr19	10106788	10106788	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctttcagacctggatgcccgGggagacccttgggggaggag	7	7	17	10	1	1	2	1	0	0	2	1	6	1	5	3	6	1	0	3	6	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:10106788G>A	uc002mmq.1	-	15	1573	c.1487C>T	c.(1486-1488)CCC>CTC	p.P496L		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	496	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TGGATGCCCGGGGAGACCCTT	0.592													30	108					0	0	0	0	A	10106788	A	A	10106788	3	1	276	1	0	0	0	0	1	0	0	0	3713	1232	43	4	3962	4	COL5A3	19	10106788	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	617130	10106788	49022195	1781	51670											
RAVER1	125950	broad.mit.edu	37	chr19	10428229	10428229	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttctgggctgggctcgggCgagggcagcaggtgggcaaa	6	6	19	10	2	1	0	0	0	1	0	2	1	1	0	1	6	1	5	1	6	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:10428229C>T	uc002moa.2	-	13	2252	c.2172G>A	c.(2170-2172)TCG>TCA	p.S724S	FDX1L_uc002mnx.1_5'Flank|FDX1L_uc002mny.1_5'Flank|RAVER1_uc002mnz.2_Missense_Mutation_p.R122H	NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	Error:Variant_position_missing_in_Q8IY67_after_alignment						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			TGGGCTCGGGCGAGGGCAGCA	0.701													14	28					0	0	0	0	T	10428229	T	T	10428229	2	4	276	1	0	0	0	0	0	0	0	1	13159	755	27	1		1	RAVER1	19	10428229	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	321441	10428229	48700754	1782	51671											
PDE4A	5141	broad.mit.edu	37	chr19	10578238	10578238	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctgcgcagggacatttgggGaggacacatccgcactccca	9	6	12	14	2	0	0	0	0	0	0	2	3	2	3	3	4	1	2	3	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:10578238G>A	uc002moj.2	+	15	2710	c.2602G>A	c.(2602-2604)GAG>AAG	p.E868K	PDE4A_uc002mok.2_Missense_Mutation_p.E842K|PDE4A_uc002mol.2_Missense_Mutation_p.E807K|PDE4A_uc002mom.2_Missense_Mutation_p.E629K|PDE4A_uc002mon.2_Missense_Mutation_p.E323K|PDE4A_uc002moo.2_3'UTR	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	868					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	GACATTTGGGGAGGACACATC	0.692													32	42					0	0	0	0	A	10578238	A	A	10578238	3	1	276	1	0	0	0	0	1	0	0	0	11693	1175	41	2	3117	2	PDE4A	19	10578238	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	150009	10578238	48550745	1783	51672											
RGL3	57139	broad.mit.edu	37	chr19	11526779	11526779	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggggggtctcggaaatcCtgagggtggtcctgcagcca	7	7	17	10	1	1	1	0	1	1	0	4	2	3	2	3	6	2	2	3	6	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:11526779C>T	uc002mrp.2	-	5	535	c.471G>A	c.(469-471)CAG>CAA	p.Q157Q	RGL3_uc002mrn.2_5'UTR|RGL3_uc002mrm.2_5'UTR|RGL3_uc002mro.2_Silent_p.Q157Q	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	157	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						CTCGGAAATCCTGAGGGTGGT	0.627													10	30					0	0	0	0	T	11526779	T	T	11526779	2	4	276	1	0	0	0	0	0	0	0	1	13343	680	24	4		4	RGL3	19	11526779	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	948541	11526779	47602204	1784	51673											
ZNF627	199692	broad.mit.edu	37	chr19	11728614	11728614	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaagccttcagtcgatccacTtactttcgagtacatgaaaa	14	11	6	10	2	1	1	1	1	0	0	4	3	2	1	2	0	3	1	2	0	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:11728614T>C	uc002msk.2	+	4	1504	c.1296T>C	c.(1294-1296)ACT>ACC	p.T432T	ZNF627_uc010dyf.2_Silent_p.T322T	NM_145295	NP_660338	Q7L945	ZN627_HUMAN	zinc finger protein 627	432	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						GTCGATCCACTTACTTTCGAG	0.433													20	31					0	0	0	0	C	11728614	C	C	11728614	2	2	276	1	0	0	0	0	0	0	0	1	18118	1596	56	5		5	ZNF627	19	11728614	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	201835	11728614	47400369	1785	51674											
ZNF799	90576	broad.mit.edu	37	chr19	12502624	12502624	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccacacaacttacatttataAggtccatctccacgctgcac	12	10	4	15	1	1	0	0	0	1	0	3	0	2	0	3	1	3	2	3	1	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:12502624A>C	uc010dyt.2	-	4	738	c.588T>G	c.(586-588)CCT>CCG	p.P196P	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Q196*(1)		breast(3)|ovary(2)|skin(1)	6						TACATTTATAAGGTCCATCTC	0.408													27	90					0	0	0	0	C	12502624	C	C	12502624	2	2	276	1	0	0	0	0	0	0	0	1	18233	59	3	5		5	ZNF799	19	12502624	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	774010	12502624	46626359	1786	51675											
JUNB	3726	broad.mit.edu	37	chr19	12902926	12902926	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acagtacttttacccccgcgGgggtggcagcggtggaggtg	6	8	17	10	3	0	0	0	0	0	0	0	1	0	1	2	6	3	2	2	6	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:12902926G>A	uc002mvc.2	+	1	617	c.341G>A	c.(340-342)GGG>GAG	p.G114E	JUNB_uc002mvb.2_RNA	NM_002229	NP_002220	P17275	JUNB_HUMAN	jun B proto-oncogene	114						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			lung(2)|central_nervous_system(1)	3						TACCCCCGCGGGGGTGGCAGC	0.667													4	11					0	0	0	0	A	12902926	A	A	12902926	3	1	276	1	0	0	0	0	1	0	0	0	8009	1232	43	4	343	4	JUNB	19	12902926	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	400302	12902926	46226057	1787	51676											
TRMT1	55621	broad.mit.edu	37	chr19	13223747	13223747	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcacagctgcatccaggaaGgtggctgggctgccataggg	8	7	16	10	0	0	0	0	0	0	0	1	1	1	1	2	5	4	5	2	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:13223747G>A	uc002mwj.2	-	5	970	c.720C>T	c.(718-720)ACC>ACT	p.T240T	TRMT1_uc002mwk.2_Silent_p.T240T|TRMT1_uc002mwl.3_Silent_p.T240T|TRMT1_uc010xmz.1_Silent_p.T26T	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	240							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		CATCCAGGAAGGTGGCTGGGC	0.617													5	30					0	0	0	0	A	13223747	A	A	13223747	2	1	276	1	0	0	0	0	0	0	0	1	16628	987	35	4		4	TRMT1	19	13223747	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	320821	13223747	45905236	1788	51677											
DCAF15	90379	broad.mit.edu	37	chr19	14070848	14070849	+	Missense_Mutation	DNP	CC	TT	TT																															cattggcctgctgctcctggCcttcccgtcccccactgagg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:14070848_14070849CC>TT	uc002mxt.2	+	10	1499_1500	c.1493_1494CC>TT	c.(1492-1494)GCC>GTT	p.A498V	DCAF15_uc002mxu.2_RNA	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	498										central_nervous_system(1)	1						CTGCTCCTGGCCTTCCCGTCCC	0.653											OREG0025301	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	28					0	0	0	0	TT	14070849	TT	TT	14070848	3	4	276	1	0	0	0	0	1	0	0	0	4284	739	26	4	1531	4	DCAF15	19	14070848	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	847101	14070848	45058135	1789	51678											
PKN1	5585	broad.mit.edu	37	chr19	14554311	14554311	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agtcccctggtgcgggtggcCccacctgctcggccaccaac	5	6	12	18	2	0	0	0	0	0	0	2	0	1	0	7	4	3	1	7	4	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:14554311C>T	uc002myp.2	+	3	520	c.352C>T	c.(352-354)CCC>TCC	p.P118S	PKN1_uc002myq.2_Missense_Mutation_p.P124S	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	118					activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8						TGCGGGTGGCCCCACCTGCTC	0.662													6	11					0	0	0	0	T	14554311	T	T	14554311	3	4	276	1	0	0	0	0	1	0	0	0	12034	623	22	4	405	4	PKN1	19	14554311	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	483463	14554311	44574672	1790	51679											
C19orf44	84167	broad.mit.edu	37	chr19	16611992	16611992	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgatgctggtcttccaaagaGagctgacagaatcctctctg	10	10	10	11	1	2	3	0	1	2	2	5	5	4	3	2	1	2	2	2	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:16611992G>A	uc002neh.1	+	2	462	c.389G>A	c.(388-390)AGA>AAA	p.R130K	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.R130K|C19orf44_uc002neg.2_Missense_Mutation_p.R130K|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	130											0						CTTCCAAAGAGAGCTGACAGA	0.527													10	30					0	0	0	0	A	16611992	A	A	16611992	3	1	276	1	0	0	0	0	1	0	0	0	1936	942	33	2	391	2	C19orf44	19	16611992	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2057681	16611992	42516991	1791	51680											
C19orf44	84167	broad.mit.edu	37	chr19	16612055	16612055	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccagaacacagacaaaacttCccagaatcaagcccgtgaac	17	4	6	14	1	1	4	1	1	0	3	2	4	2	4	3	0	4	0	3	0	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:16612055C>T	uc002neh.1	+	2	525	c.452C>T	c.(451-453)TCC>TTC	p.S151F	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.S151F|C19orf44_uc002neg.2_Missense_Mutation_p.S151F|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	151											0						GACAAAACTTCCCAGAATCAA	0.483													24	21					0	0	0	0	T	16612055	T	T	16612055	3	4	276	1	0	0	0	0	1	0	0	0	1936	855	30	2	454	2	C19orf44	19	16612055	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	63	16612055	42516928	1792	51681											
CPAMD8	27151	broad.mit.edu	37	chr19	17104264	17104264	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggctgacgtggggatggaggGgatttcaaaccccactagtc	9	8	15	9	1	1	1	1	1	0	0	2	4	1	4	2	6	1	1	2	6	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:17104264G>A	uc002nfb.2	-	12	1401	c.1369C>T	c.(1369-1371)CCC>TCC	p.P457S		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	410						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GGGATGGAGGGGATTTCAAAC	0.577													8	19					0	0	0	0	A	17104264	A	A	17104264	3	1	276	1	0	0	0	0	1	0	0	0	3810	1232	43	4	4553	4	CPAMD8	19	17104264	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	492209	17104264	42024719	1793	51682											
PLVAP	83483	broad.mit.edu	37	chr19	17476205	17476205	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttggccaggttgtctcgttCcttccgcagcaccgccttct	3	13	9	16	3	2	0	0	0	2	0	5	0	4	0	5	2	1	4	5	2	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:17476205C>T	uc002ngk.1	-	3	1119	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	357	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						TTGTCTCGTTCCTTCCGCAGC	0.622													38	38					0	0	0	0	T	17476205	T	T	17476205	3	4	276	1	0	0	0	0	1	0	0	0	12171	864	30	2	275	2	PLVAP	19	17476205	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	371941	17476205	41652778	1794	51683											
MAP1S	55201	broad.mit.edu	37	chr19	17838435	17838435	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccctgtgaatttgagcatCgcaaggcggtgccaatggca	10	8	12	11	2	0	2	0	2	0	0	1	2	0	2	2	3	2	3	2	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:17838435C>T	uc002nhe.1	+	5	2251	c.2242C>T	c.(2242-2244)CGC>TGC	p.R748C	MAP1S_uc010eba.1_Intron|MAP1S_uc002nhf.1_5'UTR|MAP1S_uc010xpv.1_Missense_Mutation_p.R722C	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	748	Pro-rich.|Necessary for the microtubule-organizing center localization.|Necessary for association with microtubules.|Necessary for interaction with RASSF1 isoform A and isoform C.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						ATTTGAGCATCGCAAGGCGGT	0.701													5	12					0	0	0	0	T	17838435	T	T	17838435	3	4	276	1	0	0	0	0	1	0	0	0	9287	884	31	1	2260	1	MAP1S	19	17838435	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	362230	17838435	41290548	1795	51684											
IL12RB1	3594	broad.mit.edu	37	chr19	18182998	18182998	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttcgaggagatgacagccacGttgtaggcagcacccgagag	11	6	14	10	3	0	3	0	1	0	2	1	6	0	3	2	2	2	4	2	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:18182998G>A	uc002nhw.1	-	9	1009	c.945C>T	c.(943-945)AAC>AAT	p.N315N	IL12RB1_uc010xqb.1_Silent_p.N315N|IL12RB1_uc002nhx.1_Silent_p.N355N|IL12RB1_uc002nhy.2_Silent_p.N315N	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	315	Extracellular (Potential).|Fibronectin type-III 3.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						TGACAGCCACGTTGTAGGCAG	0.617													12	21					0	0	0	0	A	18182998	A	A	18182998	2	1	276	1	0	0	0	0	0	0	0	1	7665	1136	40	1		1	IL12RB1	19	18182998	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	344563	18182998	40945985	1796	51685											
ISYNA1	51477	broad.mit.edu	37	chr19	18548556	18548556	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccggaaggtgaagcgcgtGgacgtggggtgcacctgaag	8	6	19	8	4	0	2	0	2	0	0	1	4	1	4	2	5	2	1	2	5	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:18548556G>A	uc002njd.1	-	3	185	c.135C>T	c.(133-135)TCC>TCT	p.S45S	ISYNA1_uc002nja.1_5'Flank|ISYNA1_uc002njb.1_5'UTR|ISYNA1_uc002njc.1_Intron|ISYNA1_uc010xqh.1_5'UTR|ISYNA1_uc002nje.1_Intron|ISYNA1_uc002njf.1_Intron	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	45					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2						TGAAGCGCGTGGACGTGGGGT	0.721													3	4					0	0	0	0	A	18548556	A	A	18548556	2	1	276	1	0	0	0	0	0	0	0	1	7906	1335	47	4		4	ISYNA1	19	18548556	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	365558	18548556	40580427	1797	51686											
NCAN	1463	broad.mit.edu	37	chr19	19337547	19337547	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccatgctggcctcatggcCcactggggaagtgtggctaa	7	8	13	13	0	1	0	1	0	0	0	1	1	1	1	4	5	1	2	4	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:19337547C>T	uc002nlz.2	+	7	1424	c.1325C>T	c.(1324-1326)CCC>CTC	p.P442L	NCAN_uc010ecc.1_Missense_Mutation_p.P6L	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	442					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GCCTCATGGCCCACTGGGGAA	0.622													4	17					0	0	0	0	T	19337547	T	T	19337547	3	4	276	1	0	0	0	0	1	0	0	0	10258	623	22	4	1347	4	NCAN	19	19337547	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	788991	19337547	39791436	1798	51687											
ZNF676	163223	broad.mit.edu	37	chr19	22363931	22363931	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccacattcttcacatttgtaGggtttctctccagtatgaat	9	16	6	10	0	3	1	1	1	2	0	5	1	4	1	2	1	0	3	2	1	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:22363931G>A	uc002nqs.1	-	3	906	c.588C>T	c.(586-588)CCC>CCT	p.P196P		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CACATTTGTAGGGTTTCTCTC	0.348													33	43					0	0	0	0	A	22363931	A	A	22363931	2	1	276	1	0	0	0	0	0	0	0	1	18150	987	35	4		4	ZNF676	19	22363931	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3026384	22363931	36765052	1799	51688											
ZNF99	7652	broad.mit.edu	37	chr19	22940685	22940685	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	acattcttcacatttgtaggGtttctcttcagtatgaatta	10	18	6	7	0	4	1	2	1	2	0	5	1	4	1	0	1	0	3	0	1	4	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:22940685G>A	uc010xrh.1	-	5	1753	c.1753C>T	c.(1753-1755)CCC>TCC	p.P585S		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CATTTGTAGGGTTTCTCTTCA	0.368													21	22					0	0	0	0	A	22940685	A	A	22940685	3	1	276	1	0	0	0	0	1	0	0	0	18271	1261	44	4	1371	4	ZNF99	19	22940685	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	576754	22940685	36188298	1800	51689											
ZNF99	7652	broad.mit.edu	37	chr19	22941815	22941815	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctttatgtctagtaaggTgtgaggattgcttaaaagct	10	16	11	4	0	1	1	0	1	1	0	1	2	1	2	0	2	3	4	0	2	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:22941815T>G	uc010xrh.1	-	5	623	c.623A>C	c.(622-624)CAC>CCC	p.H208P		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCTAGTAAGGTGTGAGGATTG	0.358													16	40					0	0	0	0	G	22941815	G	G	22941815	3	3	276	1	0	0	0	0	1	0	0	0	18271	1696	59	5	2501	5	ZNF99	19	22941815	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1130	22941815	36187168	1801	51690											
UQCRFS1	7386	broad.mit.edu	37	chr19	29698650	29698650	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caaacacctatcaggataacCcattcaggtttctttactcg	12	12	5	12	1	3	0	2	0	1	0	4	1	3	1	2	2	3	1	2	2	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:29698650C>T	uc002nsd.2	-	2	741	c.630G>A	c.(628-630)TGG>TGA	p.W210*		NM_006003	NP_005994	P47985	UCRI_HUMAN	ubiquinol-cytochrome c reductase, Rieske	210	Rieske.				respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity				0	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)			TCAGGATAACCCATTCAGGTT	0.453													45	146					0	0	0	0	T	29698650	T	T	29698650	4	4	276	1	0	0	0	0	0	1	0	0	17089	624	22	4	198	4	UQCRFS1	19	29698650	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6756835	29698650	29430333	1802	51691											
C19orf2	8725	broad.mit.edu	37	chr19	30503326	30503326	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgataggcggggagtttTgaggagtatcagctgcgaag	10	10	17	4	2	1	3	1	3	0	0	1	6	1	5	0	4	2	3	0	4	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:30503326T>G	uc002nsr.2	+	10	1343	c.1313T>G	c.(1312-1314)TTG>TGG	p.L438W	C19orf2_uc002nsq.2_Missense_Mutation_p.L420W|C19orf2_uc002nss.2_Missense_Mutation_p.L398W|C19orf2_uc002nst.2_Missense_Mutation_p.L362W	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	438					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		CGGGGAGTTTTGAGGAGTATC	0.453													17	54					0	0	0	0	G	30503326	G	G	30503326	3	3	276	1	0	0	0	0	1	0	0	0	1920	1821	63	5	1351	5	C19orf2	19	30503326	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	804676	30503326	28625657	1803	51692											
RHPN2	85415	broad.mit.edu	37	chr19	33493156	33493156	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccccccaggccttaccctGgtggtcgatgaggaggatgg	8	7	14	12	1	0	1	0	1	0	0	1	4	0	3	5	6	2	0	5	6	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:33493156G>A	uc002nuf.2	-	9	1168	c.1102C>T	c.(1102-1104)CAG>TAG	p.Q368*	RHPN2_uc010xro.1_Nonsense_Mutation_p.Q217*|RHPN2_uc002nue.2_Nonsense_Mutation_p.Q98*	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	368	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					GCCTTACCCTGGTGGTCGATG	0.632													8	17					0	0	0	0	A	33493156	A	A	33493156	4	1	276	1	0	0	0	0	0	1	0	0	13416	1357	47	4	986	4	RHPN2	19	33493156	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2989830	33493156	25635827	1804	51693											
CHST8	64377	broad.mit.edu	37	chr19	34262944	34262944	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacttatccagtggggcccCgaggggccgcaacctgccag	7	5	15	14	2	0	0	0	0	0	0	1	2	1	1	6	5	2	1	6	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:34262944C>T	uc002nus.3	+	5	756	c.251C>T	c.(250-252)CCG>CTG	p.P84L	CHST8_uc002nut.3_Missense_Mutation_p.P84L|CHST8_uc002nuu.2_Missense_Mutation_p.P84L	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	84	Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					AGTGGGGCCCCGAGGGGCCGC	0.672													7	38					0	0	0	0	T	34262944	T	T	34262944	3	4	276	1	0	0	0	0	1	0	0	0	3425	652	23	1	261	1	CHST8	19	34262944	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	769788	34262944	24866039	1805	51694											
LSM14A	26065	broad.mit.edu	37	chr19	34710646	34710646	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacaggagaagcctgtaaatGgtgaagataaaggagactca	18	6	12	5	0	1	4	1	1	0	3	1	6	1	4	1	3	2	1	1	3	7	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:34710646G>A	uc002nvb.3	+	8	1196	c.1000G>A	c.(1000-1002)GGT>AGT	p.G334S	LSM14A_uc002nva.3_Missense_Mutation_p.G334S|LSM14A_uc010xru.1_Missense_Mutation_p.G293S|LSM14A_uc002nvc.3_Missense_Mutation_p.G140S	NM_001114093	NP_001107565	Q8ND56	LS14A_HUMAN	LSM14 homolog A isoform a	334					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				skin(1)	1	Esophageal squamous(110;0.162)					GCCTGTAAATGGTGAAGATAA	0.358													9	20					0	0	0	0	A	34710646	A	A	34710646	3	1	276	1	0	0	0	0	1	0	0	0	9104	1348	47	4	1030	4	LSM14A	19	34710646	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	447702	34710646	24418337	1806	51695											
ZNF302	55900	broad.mit.edu	37	chr19	35175542	35175542	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttgtaatagagagaaaatCtatacatgcagtgaatgtgg	16	11	10	4	0	1	3	0	1	1	2	1	4	1	3	0	1	2	2	0	1	7	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:35175542C>T	uc002nvr.1	+	6	995	c.732C>T	c.(730-732)ATC>ATT	p.I244I	ZNF302_uc002nvp.1_Silent_p.I200I|ZNF302_uc002nvq.1_Silent_p.I200I|ZNF302_uc002nvs.1_Silent_p.I200I	NM_018443	NP_060913	Q9NR11	ZN302_HUMAN	zinc finger protein 302	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GAGAGAAAATCTATACATGCA	0.413													36	149					0	0	0	0	T	35175542	T	T	35175542	2	4	276	1	0	0	0	0	0	0	0	1	17899	903	32	2		2	ZNF302	19	35175542	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	464896	35175542	23953441	1807	51696											
ZNF792	126375	broad.mit.edu	37	chr19	35449808	35449808	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggagtgctggctgaagaaTtttccacattcacagcactc	10	11	9	11	0	1	2	1	1	0	1	3	3	2	3	1	2	2	3	1	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:35449808T>C	uc002nxh.1	-	4	1338	c.951A>G	c.(949-951)AAA>AAG	p.K317K		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	317	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GGCTGAAGAATTTTCCACATT	0.488													5	18					0	0	0	0	C	35449808	C	C	35449808	2	2	276	1	0	0	0	0	0	0	0	1	18231	1490	52	5		5	ZNF792	19	35449808	Silent	SNP	T	TCGA-D6-6516-01A-11D-1870-08	274266	35449808	23679175	1808	51697											
FAM187B	148109	broad.mit.edu	37	chr19	35715962	35715962	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgggtttgaactgggccacGagctcctgctgcacgaagca	8	7	14	12	3	0	1	0	1	0	0	1	3	1	1	2	2	5	5	2	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:35715962G>A	uc002nyk.1	-	2	921	c.876C>T	c.(874-876)CTC>CTT	p.L292L		NM_152481	NP_689694	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	292	Extracellular (Potential).					integral to membrane				ovary(2)	2						ACTGGGCCACGAGCTCCTGCT	0.662													8	33					0	0	0	0	A	35715962	A	A	35715962	2	1	276	1	0	0	0	0	0	0	0	1	5541	1045	37	1		1	FAM187B	19	35715962	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	266154	35715962	23413021	1809	51698											
FFAR2	2867	broad.mit.edu	37	chr19	35941446	35941446	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgctcttctatttctcttCttcagtggtgcgcagggcat	4	16	9	12	1	5	0	1	0	4	0	6	0	5	0	1	2	2	3	1	2	1	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:35941446C>G	uc002nzg.2	+	2	910	c.830C>G	c.(829-831)TCT>TGT	p.S277C	FFAR2_uc010eea.2_Missense_Mutation_p.S277C	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	277	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TATTTCTCTTCTTCAGTGGTG	0.582													32	107					0	0	0	0	G	35941446	G	G	35941446	3	3	276	1	0	0	0	0	1	0	0	0	5860	913	32	2	832	2	FFAR2	19	35941446	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	225484	35941446	23187537	1810	51699											
C19orf55	148137	broad.mit.edu	37	chr19	36250286	36250286	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttgcagcctgccagtttTctccattcaagatagtccct	7	14	6	14	0	3	1	1	0	2	1	5	1	4	1	4	0	3	2	4	0	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:36250286T>G	uc002obq.1	+	2	96	c.23T>G	c.(22-24)TTC>TGC	p.F8C	HSPB6_uc002obn.1_5'Flank|C19orf55_uc002obp.2_Missense_Mutation_p.F8C|C19orf55_uc002obo.1_Missense_Mutation_p.F8C	NM_001039887	NP_001034976	Q2NL68	CS055_HUMAN	hypothetical protein LOC148137	8										ovary(1)	1	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTGCCAGTTTTCTCCATTCAA	0.592													3	19					0	0	0	0	G	36250286	G	G	36250286	3	3	276	1	0	0	0	0	1	0	0	0	1946	1783	62	5	29	5	C19orf55	19	36250286	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	308840	36250286	22878697	1811	51700											
KIRREL2	84063	broad.mit.edu	37	chr19	36351440	36351440	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtgggcaaaagggggctctCcggtgctcggggcccgcggg	4	5	21	11	4	1	0	0	0	1	0	3	0	1	0	2	8	1	3	2	8	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:36351440C>T	uc002ocb.3	+	7	1011	c.799C>T	c.(799-801)CCG>TCG	p.P267S	KIRREL2_uc002obz.3_Missense_Mutation_p.P267S|KIRREL2_uc002oca.3_Missense_Mutation_p.P217S|KIRREL2_uc002occ.3_Missense_Mutation_p.P214S|KIRREL2_uc002ocd.3_Missense_Mutation_p.P264S	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	267	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGGGGGCTCTCCGGTGCTCGG	0.647													19	45					0	0	0	0	T	36351440	T	T	36351440	3	4	276	1	0	0	0	0	1	0	0	0	8364	855	30	2	825	2	KIRREL2	19	36351440	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	101154	36351440	22777543	1812	51701											
KIRREL2	84063	broad.mit.edu	37	chr19	36353414	36353414	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gacttgctgcccactgtgcgGatagtggccggagtggccgc	5	8	16	12	3	0	0	0	0	0	0	0	3	0	2	3	4	3	1	3	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:36353414G>A	uc002ocb.3	+	12	1742	c.1530G>A	c.(1528-1530)CGG>CGA	p.R510R	KIRREL2_uc002obz.3_Silent_p.R510R|KIRREL2_uc002oca.3_Silent_p.R460R|KIRREL2_uc002occ.3_Silent_p.R457R|KIRREL2_uc002ocd.3_Intron	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	510	Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCACTGTGCGGATAGTGGCCG	0.627													30	131					0	0	0	0	A	36353414	A	A	36353414	2	1	276	1	0	0	0	0	0	0	0	1	8364	1161	41	2		2	KIRREL2	19	36353414	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1974	36353414	22775569	1813	51702											
WDR62	284403	broad.mit.edu	37	chr19	36573968	36573968	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgtccttcctgcagaccCtgctgaaggtcgtgtacgtg	5	11	11	14	2	0	2	0	1	0	1	3	2	2	2	4	1	3	3	4	1	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:36573968C>T	uc002odc.2	+	11	1466	c.1375C>T	c.(1375-1377)CTG>TTG	p.L459L	WDR62_uc002odd.2_Silent_p.L459L	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	459					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCTGCAGACCCTGCTGAAGGT	0.468													4	15					0	0	0	0	T	36573968	T	T	36573968	2	4	276	1	0	0	0	0	0	0	0	1	17381	680	24	4		4	WDR62	19	36573968	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	220554	36573968	22555015	1814	51703											
ZNF420	147923	broad.mit.edu	37	chr19	37618342	37618342	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgtgggaaagccttcagacGagcctcacacctaacacaac	14	6	8	13	1	2	1	2	0	0	1	2	3	2	2	3	1	4	0	3	1	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:37618342G>A	uc002ofl.2	+	5	664	c.449G>A	c.(448-450)CGA>CAA	p.R150Q		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	150	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GCCTTCAGACGAGCCTCACAC	0.398													12	45					0	0	0	0	A	37618342	A	A	37618342	3	1	276	1	0	0	0	0	1	0	0	0	17964	1058	37	1	459	1	ZNF420	19	37618342	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1044374	37618342	21510641	1815	51704											
ZNF527	84503	broad.mit.edu	37	chr19	37880348	37880348	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acatcagagaattcataccgGagaaaagccctatgaatgca	17	7	8	9	1	2	3	2	1	0	2	2	5	2	3	2	1	3	1	2	1	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:37880348G>A	uc010efk.1	+	5	1508	c.1397G>A	c.(1396-1398)GGA>GAA	p.G466E	ZNF527_uc002ogf.3_Missense_Mutation_p.G434E|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTCATACCGGAGAAAAGCCC	0.408													9	55					0	0	0	0	A	37880348	A	A	37880348	3	1	276	1	0	0	0	0	1	0	0	0	18035	1174	41	2	1411	2	ZNF527	19	37880348	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	262006	37880348	21248635	1816	51705											
ZNF607	84775	broad.mit.edu	37	chr19	38189304	38189304	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagttcggtcatgatatatGaggcttgtggcatgacgaaa	11	12	13	5	2	1	4	1	4	0	0	2	5	1	4	0	3	0	3	0	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:38189304G>A	uc002ohc.1	-	5	2324	c.1728C>T	c.(1726-1728)CTC>CTT	p.L576L	ZNF607_uc002ohb.1_Silent_p.L575L	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	576	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			CATGATATATGAGGCTTGTGG	0.403													10	36					0	0	0	0	A	38189304	A	A	38189304	2	1	276	1	0	0	0	0	0	0	0	1	18100	1277	45	2		2	ZNF607	19	38189304	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	308956	38189304	20939679	1817	51706											
SIPA1L3	23094	broad.mit.edu	37	chr19	38655373	38655373	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagtatgggcctttgtggCgggggtcgcgaggccgctgg	4	8	21	8	4	0	0	0	0	0	0	1	2	0	1	2	7	0	2	2	7	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:38655373C>G	uc002ohk.2	+	15	4544	c.4035C>G	c.(4033-4035)GGC>GGG	p.G1345G		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1345					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCCTTTGTGGCGGGGGTCGCG	0.692													5	15					0	0	0	0	G	38655373	G	G	38655373	2	3	276	1	0	0	0	0	0	0	0	1	14396	755	27	3		3	SIPA1L3	19	38655373	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	466069	38655373	20473610	1818	51707											
CATSPERG	57828	broad.mit.edu	37	chr19	38847129	38847129	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccttgctctgcagatggcCaggtgtcctttgagatgctg	6	12	13	10	0	1	2	0	1	1	2	2	4	2	2	3	2	3	3	3	2	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:38847129C>T	uc002oih.3	+	10	1228	c.1141C>T	c.(1141-1143)CAG>TAG	p.Q381*	CATSPERG_uc002oig.3_Nonsense_Mutation_p.Q381*|CATSPERG_uc002oif.3_Nonsense_Mutation_p.Q21*|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	381	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						TGCAGATGGCCAGGTGTCCTT	0.607													11	63					0	0	0	0	T	38847129	T	T	38847129	4	4	276	1	0	0	0	0	0	1	0	0	2704	595	21	4	1175	4	CATSPERG	19	38847129	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	191756	38847129	20281854	1819	51708											
CATSPERG	57828	broad.mit.edu	37	chr19	38858334	38858334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctggtagctatgttctgctgGtggtgggtggcgggcccaca	4	11	17	9	1	1	0	0	0	1	0	1	0	1	0	1	6	2	4	1	6	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:38858334G>A	uc002oih.3	+	25	2935	c.2848G>A	c.(2848-2850)GTG>ATG	p.V950M	CATSPERG_uc002oig.3_Missense_Mutation_p.V910M|CATSPERG_uc002oif.3_Missense_Mutation_p.V590M|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	950	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						TGTTCTGCTGGTGGTGGGTGG	0.607													68	251					0	0	0	0	A	38858334	A	A	38858334	3	1	276	1	0	0	0	0	1	0	0	0	2704	1261	44	4	2942	4	CATSPERG	19	38858334	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	11205	38858334	20270649	1820	51709											
PSMD8	5714	broad.mit.edu	37	chr19	38871607	38871607	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atccccgccgagagctacacCttcttcattgacatcctgct	8	11	6	16	2	2	2	1	1	1	1	4	3	4	2	5	0	3	2	5	0	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:38871607C>T	uc002oii.3	+	5	823	c.771C>T	c.(769-771)ACC>ACT	p.T257T	PSMD8_uc010efx.1_Silent_p.T90T	NM_002812	NP_002803	P48556	PSMD8_HUMAN	proteasome 26S non-ATPase subunit 8	257					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome regulatory particle	protein binding			central_nervous_system(1)	1	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGAGCTACACCTTCTTCATTG	0.468													3	7					0	0	0	0	T	38871607	T	T	38871607	2	4	276	1	0	0	0	0	0	0	0	1	12766	668	24	4		4	PSMD8	19	38871607	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	13273	38871607	20257376	1821	51710											
GGN	199720	broad.mit.edu	37	chr19	38877078	38877078	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacctgaggcagcaaagaggCcgccgcctccgccgcccccc	7	2	11	21	4	0	2	0	1	0	1	1	2	1	2	9	2	1	2	9	2	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:38877078C>T	uc002oij.1	-	3	959	c.824G>A	c.(823-825)GGC>GAC	p.G275D	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Missense_Mutation_p.G192D	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	275	Interaction with GGNBP1 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGCAAAGAGGCCGCCGCCTCC	0.647													11	35					0	0	0	0	T	38877078	T	T	38877078	3	4	276	1	0	0	0	0	1	0	0	0	6395	739	26	4	1142	4	GGN	19	38877078	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5471	38877078	20251905	1822	51711											
SIRT2	22933	broad.mit.edu	37	chr19	39369801	39369801	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggagatgcagctgtcactgGggtttctccctctctgttgt	4	14	13	10	0	3	1	1	0	2	1	5	2	3	1	1	3	2	4	1	3	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:39369801G>A	uc002ojt.1	-	16	1364	c.1164C>T	c.(1162-1164)CCC>CCT	p.P388P	RINL_uc002ojq.2_5'Flank|RINL_uc010xuo.1_5'Flank|SIRT2_uc010egh.1_3'UTR|SIRT2_uc010egi.1_Silent_p.P351P|SIRT2_uc002ojs.1_Silent_p.P368P|SIRT2_uc002oju.1_Silent_p.P351P|SIRT2_uc010egj.1_Silent_p.P351P|SIRT2_uc002ojv.1_Silent_p.P386P	NM_012237	NP_036369	Q8IXJ6	SIRT2_HUMAN	sirtuin 2 isoform 1	388					cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			GCTGTCACTGGGGTTTCTCCC	0.657													17	32					0	0	0	0	A	39369801	A	A	39369801	2	1	276	1	0	0	0	0	0	0	0	1	14403	1219	43	4		4	SIRT2	19	39369801	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	492723	39369801	19759182	1823	51712											
PAK4	10298	broad.mit.edu	37	chr19	39664427	39664427	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccccctggcccccgctcacCacagcgggagccacagcgag	7	2	12	20	3	1	0	1	0	0	0	1	2	1	1	6	2	3	1	6	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:39664427C>T	uc002okj.1	+	6	1336	c.875C>T	c.(874-876)CCA>CTA	p.P292L	PAK4_uc002okl.1_Missense_Mutation_p.P292L|PAK4_uc002okn.1_Missense_Mutation_p.P292L|PAK4_uc002okm.1_Missense_Mutation_p.P139L|PAK4_uc002oko.1_Missense_Mutation_p.P139L|PAK4_uc002okp.1_Missense_Mutation_p.P202L	NM_001014831	NP_001014831	O96013	PAK4_HUMAN	p21-activated kinase 4 isoform 1	292	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			CCCCGCTCACCACAGCGGGAG	0.711													6	10					0	0	0	0	T	39664427	T	T	39664427	3	4	276	1	0	0	0	0	1	0	0	0	11457	594	21	4	885	4	PAK4	19	39664427	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	294626	39664427	19464556	1824	51713											
NCCRP1	342897	broad.mit.edu	37	chr19	39691262	39691262	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtcaccacaggtgtccCacgtattccgccattatggt	7	12	9	13	2	1	0	1	0	0	0	3	0	3	0	4	2	1	2	4	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:39691262C>T	uc002okq.1	+	6	713	c.694C>T	c.(694-696)CAC>TAC	p.H232Y		NM_001001414	NP_001001414	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1	232	FBA.				protein catabolic process					ovary(1)	1						ACAGGTGTCCCACGTATTCCG	0.602													34	102					0	0	0	0	T	39691262	T	T	39691262	3	4	276	1	0	0	0	0	1	0	0	0	10267	594	21	4	716	4	NCCRP1	19	39691262	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	26835	39691262	19437721	1825	51714											
IL28B	282617	broad.mit.edu	37	chr19	39735638	39735638	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagagagaaagggagctgagGgaatgcagaggctgcccact	13	4	16	8	0	0	4	0	1	0	3	0	7	0	6	1	3	3	3	1	3	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:39735638G>A	uc010xut.1	-						IL28B_uc010xuu.1_5'UTR	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B						response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGGAGCTGAGGGAATGCAGAG	0.587													21	27					0	0	0	0	A	39735638	A	A	39735638	1	1	276	0	1	0	0	0	0	0	0	0	7722	1247	43	4		4	IL28B	19	39735638	5'Flank	SNP	G	TCGA-D6-6516-01A-11D-1870-08	44376	39735638	19393345	1826	51715											
LRFN1	57622	broad.mit.edu	37	chr19	39804666	39804666	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctggccagcggatgagcacGgagttcgaggtgagctcggc	7	6	18	10	4	0	2	0	2	0	0	2	5	0	4	1	5	3	4	1	5	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:39804666G>A	uc002okw.2	-	1	1311	c.1311C>T	c.(1309-1311)TCC>TCT	p.S437S		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	437	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGATGAGCACGGAGTTCGAGG	0.642													11	28					0	0	0	0	A	39804666	A	A	39804666	2	1	276	1	0	0	0	0	0	0	0	1	8987	1103	39	1		1	LRFN1	19	39804666	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	69028	39804666	19324317	1827	51716											
PAF1	54623	broad.mit.edu	37	chr19	39880374	39880374	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatgtttgtgctgtttctcCaaggaagtggctttgtactg	6	17	11	7	0	2	0	1	0	1	0	3	1	2	1	1	2	2	5	1	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:39880374C>T	uc002old.2	-	4	373	c.198G>A	c.(196-198)TTG>TTA	p.L66L	PAF1_uc002ole.1_Silent_p.L56L|PAF1_uc010xuv.1_Intron|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	66					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GCTGTTTCTCCAAGGAAGTGG	0.552													29	158					0	0	0	0	T	39880374	T	T	39880374	2	4	276	1	0	0	0	0	0	0	0	1	11437	593	21	4		4	PAF1	19	39880374	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	75708	39880374	19248609	1828	51717											
PLEKHG2	64857	broad.mit.edu	37	chr19	39915563	39915564	+	Missense_Mutation	DNP	CC	TT	TT																															cgccacctcatagtcccccaCcttccagccgtcagctcctg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:39915563_39915564CC>TT	uc010xuz.1	+	19	4115_4116	c.3790_3791CC>TT	c.(3790-3792)CCT>TTT	p.P1264F	PLEKHG2_uc010xuy.1_Intron|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.P1042F	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	1264					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TAGTCCCCCACCTTCCAGCCGT	0.604													17	90					0	0	0	0	TT	39915564	TT	TT	39915563	3	4	276	1	0	0	0	0	1	0	0	0	12124	507	18	4	3860	4	PLEKHG2	19	39915563	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	35189	39915563	19213420	1829	51718											
LGALS13	29124	broad.mit.edu	37	chr19	40097949	40097949	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcaagtgtcgagagatatCtccctgacctcagtgtgtgt	8	12	12	9	1	2	2	1	1	1	1	4	4	2	2	2	0	1	1	2	0	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:40097949C>A	uc002omb.2	+	4	430	c.390C>A	c.(388-390)ATC>ATA	p.I130I		NM_013268	NP_037400	Q9UHV8	PP13_HUMAN	galectin-13	130	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			ovary(1)	1	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CGAGAGATATCTCCCTGACCT	0.468													32	50					8.16721e-17	8.45735e-17	1	0	A	40097949	A	A	40097949	2	1	276	1	0	0	0	0	0	0	0	1	8780	903	32	2		2	LGALS13	19	40097949	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	182386	40097949	19031034	1830	51719											
DYRK1B	9149	broad.mit.edu	37	chr19	40318203	40318203	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcatctccacaaggatgcAgcccagggaccacatgtcaa	12	6	10	13	0	2	0	1	0	1	0	3	2	2	2	3	2	3	2	3	2	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:40318203A>C	uc002omj.2	-	7	1181	c.901T>G	c.(901-903)TGC>GGC	p.C301G	DYRK1B_uc002omi.2_Missense_Mutation_p.C301G|DYRK1B_uc002omk.2_Missense_Mutation_p.C301G	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	301	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			ACAAGGATGCAGCCCAGGGAC	0.612													4	45					0	0	0	0	C	40318203	C	C	40318203	3	2	276	1	0	0	0	0	1	0	0	0	4877	188	7	5	1008	5	DYRK1B	19	40318203	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	220254	40318203	18810780	1831	51720											
ZNF546	339327	broad.mit.edu	37	chr19	40520411	40520412	+	Missense_Mutation	DNP	CC	TT	TT																															aaattcatactggtgaaaaaCcctacgaatgtaaagaatgt																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:40520411_40520412CC>TT	uc002oms.2	+	7	1490_1491	c.1234_1235CC>TT	c.(1234-1236)CCC>TTC	p.P412F	ZNF546_uc002omt.2_Missense_Mutation_p.P386F	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGGTGAAAAACCCTACGAATGT	0.381													19	27					0	0	0	0	TT	40520412	TT	TT	40520411	3	4	276	1	0	0	0	0	1	0	0	0	18045	507	18	4	1252	4	ZNF546	19	40520411	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	202208	40520411	18608572	1832	51721											
AKT2	208	broad.mit.edu	37	chr19	40762855	40762855	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctacggagaagttgtttaaGgggggtagagtctgatcagg	10	10	17	4	1	2	3	1	1	1	2	2	4	2	3	0	5	1	4	0	5	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:40762855G>A	uc002onf.2	-	3	415	c.153C>T	c.(151-153)CCC>CCT	p.P51P	AKT2_uc010egs.2_Silent_p.P51P|AKT2_uc010egt.2_5'UTR|AKT2_uc010xvj.1_5'UTR|AKT2_uc010egu.1_5'UTR|AKT2_uc010xvk.1_Silent_p.P51P	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	51	PH.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)			AGTTGTTTAAGGGGGGTAGAG	0.572			A		ovarian|pancreatic 								11	49					0	0	0	0	A	40762855	A	A	40762855	2	1	276	1	0	0	0	0	0	0	0	1	480	987	35	4		4	AKT2	19	40762855	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	242444	40762855	18366128	1833	51722											
PRX	57716	broad.mit.edu	37	chr19	40900834	40900834	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagcggaggcatcctcagcCccgcgtcatggccctcagtg	6	6	12	17	3	3	0	3	0	0	0	4	1	4	1	5	3	2	1	5	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:40900834C>T	uc002onr.2	-	7	3694	c.3425G>A	c.(3424-3426)GGG>GAG	p.G1142E	PRX_uc002onq.2_Missense_Mutation_p.G1003E|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1142	Glu-rich (acidic).				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CATCCTCAGCCCCGCGTCATG	0.667													10	39					0	0	0	0	T	40900834	T	T	40900834	3	4	276	1	0	0	0	0	1	0	0	0	12704	623	22	4	964	4	PRX	19	40900834	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	137979	40900834	18228149	1834	51723											
CYP2F1	1572	broad.mit.edu	37	chr19	41622463	41622463	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggaggccctggtggaccaggGagaggagtttagtggccgcg	7	6	20	8	2	0	1	0	0	0	1	0	5	0	4	3	7	0	1	3	7	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:41622463G>A	uc002opu.1	+	3	331	c.275G>A	c.(274-276)GGA>GAA	p.G92E	CYP2F1_uc010xvw.1_5'UTR|CYP2F1_uc010xvv.1_Missense_Mutation_p.G92E|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	92					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						GTGGACCAGGGAGAGGAGTTT	0.587													16	50					0	0	0	0	A	41622463	A	A	41622463	3	1	276	1	0	0	0	0	1	0	0	0	4188	1174	41	2	281	2	CYP2F1	19	41622463	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	721629	41622463	17506520	1835	51724											
HNRNPUL1	11100	broad.mit.edu	37	chr19	41809897	41809897	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtttcaaccgcagcggaggtGgtggctatagccagaaccgc	9	7	14	11	3	1	1	1	0	0	1	1	2	1	2	3	4	4	3	3	4	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:41809897G>T	uc002oqb.3	+	13	2282	c.1993G>T	c.(1993-1995)GGT>TGT	p.G665C	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Missense_Mutation_p.G565C|HNRNPUL1_uc002oqa.3_Missense_Mutation_p.G565C|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.G665C|HNRNPUL1_uc002oqc.3_Missense_Mutation_p.G551C|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Missense_Mutation_p.G565C|HNRNPUL1_uc010ehn.2_Missense_Mutation_p.G565C|HNRNPUL1_uc010eho.2_Missense_Mutation_p.G565C|HNRNPUL1_uc010xvy.1_Missense_Mutation_p.G565C|HNRNPUL1_uc010ehp.2_Missense_Mutation_p.G521C|HNRNPUL1_uc002oqf.3_Missense_Mutation_p.G189C	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	665	Gly-rich.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						CAGCGGAGGTGGTGGCTATAG	0.517													33	54					2.87052e-16	2.96886e-16	1	0	T	41809897	T	T	41809897	3	4	276	1	0	0	0	0	1	0	0	0	7313	1348	47	4	2043	4	HNRNPUL1	19	41809897	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	187434	41809897	17319086	1836	51725											
ARHGEF1	9138	broad.mit.edu	37	chr19	42399446	42399446	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagccaggtgctacagaccGgaagggaggcgtggggatgc	10	4	19	8	2	0	1	0	0	0	1	0	5	0	4	2	6	4	1	2	6	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:42399446G>A	uc002orx.2	+	12	1011	c.902G>A	c.(901-903)CGG>CAG	p.R301Q	ARHGEF1_uc002orw.1_Missense_Mutation_p.R301Q|ARHGEF1_uc002ory.2_Missense_Mutation_p.R268Q|ARHGEF1_uc002orz.2_Missense_Mutation_p.R139Q|ARHGEF1_uc002osa.2_Missense_Mutation_p.R316Q|ARHGEF1_uc002osb.2_Missense_Mutation_p.R283Q|ARHGEF1_uc002osc.2_5'UTR|ARHGEF1_uc002osd.2_5'Flank	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	301					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		GCTACAGACCGGAAGGGAGGC	0.607													16	69					0	0	0	0	A	42399446	A	A	42399446	3	1	276	1	0	0	0	0	1	0	0	0	893	1116	39	1	993	1	ARHGEF1	19	42399446	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	589549	42399446	16729537	1837	51726											
POU2F2	5452	broad.mit.edu	37	chr19	42598031	42598031	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	acaacggtaaggtccccgcgCccccttggggtgtgacctga	7	7	13	14	3	0	2	0	2	0	0	1	2	1	2	5	4	1	1	5	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:42598031C>T	uc002osp.2	-	12	1215	c.1148G>A	c.(1147-1149)GGC>GAC	p.G383D	POU2F2_uc002osn.2_Missense_Mutation_p.G367D|POU2F2_uc002oso.2_Missense_Mutation_p.G156D|POU2F2_uc002osq.2_Missense_Mutation_p.G367D|POU2F2_uc002osr.1_Missense_Mutation_p.G383D	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	383					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				GGTCCCCGCGCCCCCTTGGGG	0.617													17	88					0	0	0	0	T	42598031	T	T	42598031	3	4	276	1	0	0	0	0	1	0	0	0	12327	739	26	4	303	4	POU2F2	19	42598031	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	198585	42598031	16530952	1838	51727											
CIC	23152	broad.mit.edu	37	chr19	42794462	42794462	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccccactggaccctgagccCccagggcccccggatcctcc	5	4	9	23	1	0	1	0	1	0	0	2	3	2	3	9	3	1	0	9	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:42794462C>T	uc002otf.1	+	10	1582	c.1542C>T	c.(1540-1542)CCC>CCT	p.P514P		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	514	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				ACCCTGAGCCCCCAGGGCCCC	0.627			T	DUX4	soft tissue sarcoma								20	65					0	0	0	0	T	42794462	T	T	42794462	2	4	276	1	0	0	0	0	0	0	0	1	3439	610	22	4		4	CIC	19	42794462	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	196431	42794462	16334521	1839	51728											
CEACAM1	634	broad.mit.edu	37	chr19	43026182	43026182	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtgacactgagtagagtgagGgtcctgttgccattggacag	9	10	15	7	0	0	4	0	3	0	1	1	5	1	5	2	2	1	2	2	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:43026182G>A	uc002otv.2	-	3	710	c.597C>T	c.(595-597)ACC>ACT	p.T199T	uc010eif.1_Intron|uc002ott.1_RNA|uc010eig.1_Intron|uc010eih.1_Intron|CEACAM1_uc010eii.2_5'Flank|CEACAM1_uc002otw.2_Silent_p.T199T|CEACAM1_uc010eij.2_Silent_p.T199T|CEACAM1_uc002otx.2_Silent_p.T199T|CEACAM1_uc002oty.2_Silent_p.T199T|CEACAM1_uc002otz.2_Silent_p.T199T|CEACAM1_uc010eik.2_Intron|CEACAM1_uc002oua.2_Silent_p.T199T|CEACAM1_uc002oub.2_Silent_p.T199T|CEACAM1_uc002ouc.2_Silent_p.T199T	NM_001712	NP_001703	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion	199	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				ovary(1)|central_nervous_system(1)	2		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	GTAGAGTGAGGGTCCTGTTGC	0.532													35	203					0	0	0	0	A	43026182	A	A	43026182	2	1	276	1	0	0	0	0	0	0	0	1	3202	1219	43	4		4	CEACAM1	19	43026182	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	231720	43026182	16102801	1840	51729											
PSG4	5672	broad.mit.edu	37	chr19	43709670	43709670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gatgcgctgtgtgcagggagGggctgagaggggccccatgg	6	6	21	8	1	0	1	0	1	0	1	0	4	0	2	2	6	2	3	2	6	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:43709670G>A	uc002ovy.2	-	1	121	c.19C>T	c.(19-21)CCT>TCT	p.P7S	PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.P7S|PSG4_uc002ovz.2_Missense_Mutation_p.P7S	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	7					defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				GTGCAGGGAGGGGCTGAGAGG	0.587													6	33					0	0	0	0	A	43709670	A	A	43709670	3	1	276	1	0	0	0	0	1	0	0	0	12719	1232	43	4	1264	4	PSG4	19	43709670	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	683488	43709670	15419313	1841	51730											
IRGC	56269	broad.mit.edu	37	chr19	44223319	44223319	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cactgtgccgagcggctgcgGgaggccggcgtggctgaccc	4	5	18	14	5	0	1	0	1	0	0	0	3	0	2	3	5	3	2	3	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:44223319G>A	uc002oxh.2	+	2	756	c.609G>A	c.(607-609)CGG>CGA	p.R203R		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	203						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				AGCGGCTGCGGGAGGCCGGCG	0.701													8	52					0	0	0	0	A	44223319	A	A	44223319	2	1	276	1	0	0	0	0	0	0	0	1	7877	1219	43	4		4	IRGC	19	44223319	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	513649	44223319	14905664	1842	51731											
ZNF221	7638	broad.mit.edu	37	chr19	44466927	44466927	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attcaggactctgcaaattcCctgaagtagaaggaaaaatg	16	9	9	7	0	2	2	1	1	1	1	3	4	3	4	1	2	1	2	1	2	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:44466927C>T	uc002oxx.2	+	3	377	c.49C>T	c.(49-51)CCT>TCT	p.P17S	ZNF221_uc010ejb.1_Missense_Mutation_p.P17S|ZNF221_uc010xws.1_Missense_Mutation_p.P17S	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				CTGCAAATTCCCTGAAGTAGA	0.403													22	53					0	0	0	0	T	44466927	T	T	44466927	3	4	276	1	0	0	0	0	1	0	0	0	17842	623	22	4	51	4	ZNF221	19	44466927	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	243608	44466927	14662056	1843	51732											
ZNF233	353355	broad.mit.edu	37	chr19	44777200	44777200	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataataaatcttcaaggcaaGaggtccaagttgctaaaaca	18	9	7	7	0	2	1	1	0	1	1	3	1	3	1	1	2	2	3	1	2	8	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:44777200G>A	uc002oyz.1	+	5	514	c.387G>A	c.(385-387)AAG>AAA	p.K129K	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_5'UTR	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				TTCAAGGCAAGAGGTCCAAGT	0.378													9	62					0	0	0	0	A	44777200	A	A	44777200	2	1	276	1	0	0	0	0	0	0	0	1	17853	933	33	2		2	ZNF233	19	44777200	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	310273	44777200	14351783	1844	51733											
ZNF285	26974	broad.mit.edu	37	chr19	44891169	44891169	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccagtggacttgaagaacgGagcttgaactaaagcacttg	13	9	11	8	1	0	3	0	2	0	1	1	5	1	5	1	2	4	2	1	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:44891169G>A	uc002ozd.3	-	4	1325	c.1238C>T	c.(1237-1239)TCC>TTC	p.S413F	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.S420F	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	413	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						TTGAAGAACGGAGCTTGAACT	0.493													11	56					0	0	0	0	A	44891169	A	A	44891169	3	1	276	1	0	0	0	0	1	0	0	0	17889	1174	41	2	538	2	ZNF285	19	44891169	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	113969	44891169	14237814	1845	51734											
ZNF285	26974	broad.mit.edu	37	chr19	44891417	44891417	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actcgatgatggttgtgaagGgaagagctgcgcctgaagcc	10	8	15	8	2	0	4	0	3	0	1	1	6	0	5	2	2	3	2	2	2	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:44891417G>A	uc002ozd.3	-	4	1077	c.990C>T	c.(988-990)TCC>TCT	p.S330S	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Silent_p.S337S	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	330	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						GGTTGTGAAGGGAAGAGCTGC	0.478													29	93					0	0	0	0	A	44891417	A	A	44891417	2	1	276	1	0	0	0	0	0	0	0	1	17889	1219	43	4		4	ZNF285	19	44891417	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	248	44891417	14237566	1846	51735											
ZNF180	7733	broad.mit.edu	37	chr19	44981195	44981195	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtttataactttgactaaaGgatttcccacactgattgca	13	14	6	8	0	0	2	0	2	0	0	1	3	1	3	1	1	2	2	1	1	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:44981195G>A	uc002ozf.3	-	5	1785	c.1503C>T	c.(1501-1503)TCC>TCT	p.S501S	ZNF180_uc002ozh.3_Silent_p.S158S|ZNF180_uc002ozi.3_Silent_p.S474S|ZNF180_uc002ozg.3_Silent_p.S500S|ZNF180_uc010ejm.2_Silent_p.S476S	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	501	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				TTTGACTAAAGGATTTCCCAC	0.383													23	69					0	0	0	0	A	44981195	A	A	44981195	2	1	276	1	0	0	0	0	0	0	0	1	17815	987	35	4		4	ZNF180	19	44981195	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	89778	44981195	14147788	1847	51736											
CEACAM19	56971	broad.mit.edu	37	chr19	45179627	45179627	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cattggatctcttgctgccgGggcccttctcatcagctgca	5	12	10	14	1	3	0	2	0	2	0	5	1	3	1	2	3	4	3	2	3	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:45179627G>C	uc002ozo.3	+	3	989	c.509G>C	c.(508-510)GGG>GCG	p.G170A	CEACAM19_uc002ozp.3_Missense_Mutation_p.G170A	NM_020219	NP_064604	Q7Z692	CEA19_HUMAN	carcinoembryonic antigen-related cell adhesion	170	Helical; (Potential).					integral to membrane					0	Lung NSC(12;0.00308)|all_lung(12;0.00806)	Prostate(69;0.0376)				CTTGCTGCCGGGGCCCTTCTC	0.587													27	49					0	0	0	0	C	45179627	C	C	45179627	3	2	276	1	0	0	0	0	1	0	0	0	3205	1232	43	4	519	4	CEACAM19	19	45179627	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	198432	45179627	13949356	1848	51737											
CEACAM16	388551	broad.mit.edu	37	chr19	45209024	45209024	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggccctaaagaacggccaaGaccacctcaacatcagcagc	15	3	8	15	1	2	2	2	0	0	2	2	2	2	2	4	2	4	1	4	2	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:45209024G>A	uc010xxd.1	+	5	1032	c.826G>A	c.(826-828)GAC>AAC	p.D276N	CEACAM16_uc002ozq.2_Missense_Mutation_p.D335N	NM_001039213	NP_001034302	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion	276										ovary(1)	1	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				GAACGGCCAAGACCACCTCAA	0.577													19	43					0	0	0	0	A	45209024	A	A	45209024	3	1	276	1	0	0	0	0	1	0	0	0	3203	942	33	2	840	2	CEACAM16	19	45209024	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	29397	45209024	13919959	1849	51738											
CLPTM1	1209	broad.mit.edu	37	chr19	45495560	45495560	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtggcccaccttccctggcGcatgctcacctacaaggccc	6	8	9	18	1	1	0	1	0	0	0	2	0	2	0	5	3	2	2	5	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:45495560G>A	uc002pai.2	+	13	1640	c.1625G>A	c.(1624-1626)CGC>CAC	p.R542H	CLPTM1_uc010xxf.1_Missense_Mutation_p.R440H|CLPTM1_uc010xxg.1_Missense_Mutation_p.R528H	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	542	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		CTTCCCTGGCGCATGCTCACC	0.567													4	107					0	0	0	0	A	45495560	A	A	45495560	3	1	276	1	0	0	0	0	1	0	0	0	3569	1087	38	1	1675	1	CLPTM1	19	45495560	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	286536	45495560	13633423	1850	51739											
CLPTM1	1209	broad.mit.edu	37	chr19	45496109	45496109	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccagctctgccagcgagcCccaggaagcccctccaaagc	9	3	11	18	1	1	0	0	0	1	0	2	2	2	1	7	2	6	1	7	2	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:45496109C>T	uc002pai.2	+	14	1979	c.1964C>T	c.(1963-1965)CCC>CTC	p.P655L	CLPTM1_uc010xxf.1_Missense_Mutation_p.P553L|CLPTM1_uc010xxg.1_Missense_Mutation_p.P641L	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	655	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GCCAGCGAGCCCCAGGAAGCC	0.672													8	33					0	0	0	0	T	45496109	T	T	45496109	3	4	276	1	0	0	0	0	1	0	0	0	3569	623	22	4	2018	4	CLPTM1	19	45496109	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	549	45496109	13632874	1851	51740											
ERCC2	2068	broad.mit.edu	37	chr19	45856009	45856009	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacagagctactcaccttgaGaatgcggctctgtgtgtaga	10	10	12	9	1	2	3	1	1	1	3	2	5	2	3	1	1	3	3	1	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:45856009G>A	uc002pbj.2	-	20	1944	c.1897C>T	c.(1897-1899)CTC>TTC	p.L633F	ERCC2_uc002pbh.2_Missense_Mutation_p.L196F|ERCC2_uc002pbi.2_Missense_Mutation_p.L326F|ERCC2_uc010ejz.2_Missense_Mutation_p.L555F|ERCC2_uc002pbk.2_Missense_Mutation_p.L609F	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	633	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CTCACCTTGAGAATGCGGCTC	0.612			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				27	32					0	0	0	0	A	45856009	A	A	45856009	3	1	276	1	0	0	0	0	1	0	0	0	5237	942	33	2	401	2	ERCC2	19	45856009	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	359900	45856009	13272974	1852	51741											
PPP1R13L	10848	broad.mit.edu	37	chr19	45885876	45885876	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcccgtccctccgcagcacgGtgaccgactcgccctcgcgg	4	5	12	20	7	0	1	0	1	0	0	4	2	2	1	5	2	1	2	5	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:45885876G>A	uc002pbn.2	-	12	2434	c.2357C>T	c.(2356-2358)ACC>ATC	p.T786I	PPP1R13L_uc002pbm.2_Missense_Mutation_p.T365I|PPP1R13L_uc002pbo.2_Missense_Mutation_p.T786I	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	786	SH3.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CCGCAGCACGGTGACCGACTC	0.687													6	26					0	0	0	0	A	45885876	A	A	45885876	3	1	276	1	0	0	0	0	1	0	0	0	12418	1261	44	4	137	4	PPP1R13L	19	45885876	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	29867	45885876	13243107	1853	51742											
EML2	24139	broad.mit.edu	37	chr19	46137675	46137675	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gccacaaagtacactatctcCccggtgggcagcaaataaag	14	6	9	12	1	1	0	0	0	1	0	2	0	1	0	3	2	2	3	3	2	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:46137675C>T	uc002pcn.2	-	4	269	c.234G>A	c.(232-234)GGG>GGA	p.G78G	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Intron|EML2_uc010xxl.1_Silent_p.G225G|EML2_uc010xxm.1_Silent_p.G279G|EML2_uc010xxn.1_RNA|EML2_uc010xxo.1_Silent_p.G78G|EML2_uc010ekj.2_Silent_p.G78G	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	78					sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		ACACTATCTCCCCGGTGGGCA	0.542													9	23					0	0	0	0	T	46137675	T	T	46137675	2	4	276	1	0	0	0	0	0	0	0	1	5121	610	22	4		4	EML2	19	46137675	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	251799	46137675	12991308	1854	51743											
RSPH6A	81492	broad.mit.edu	37	chr19	46318152	46318152	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgaggctggaactctgaggGaaagcccgtgttcacagatg	10	8	14	9	1	2	3	1	2	1	1	2	5	2	5	1	3	2	2	1	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:46318152G>A	uc002pdm.2	-	1	426	c.283C>T	c.(283-285)CCC>TCC	p.P95S		NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	95						intracellular				ovary(1)|central_nervous_system(1)	2						AACTCTGAGGGAAAGCCCGTG	0.602													8	37					0	0	0	0	A	46318152	A	A	46318152	3	1	276	1	0	0	0	0	1	0	0	0	13772	1174	41	2	1894	2	RSPH6A	19	46318152	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	180477	46318152	12810831	1855	51744											
STRN4	29888	broad.mit.edu	37	chr19	47231181	47231181	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccggggctggggtgtgccagGaggcgggccagtcacttttg	4	8	19	10	2	1	0	1	0	0	0	1	1	1	1	3	7	1	1	3	7	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:47231181G>A	uc002pfl.2	-	8	1156	c.1123C>T	c.(1123-1125)CCT>TCT	p.P375S	STRN4_uc002pfm.2_Missense_Mutation_p.P375S|STRN4_uc010xyf.1_RNA|STRN4_uc010xyg.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	375						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		GGTGTGCCAGGAGGCGGGCCA	0.662													12	39					0	0	0	0	A	47231181	A	A	47231181	3	1	276	1	0	0	0	0	1	0	0	0	15397	1174	41	2	1199	2	STRN4	19	47231181	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	913029	47231181	11897802	1856	51745											
ZC3H4	23211	broad.mit.edu	37	chr19	47570606	47570606	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttccagagcacggtgcgggcGaagctgggcttgctcagggt	6	8	17	10	3	1	1	1	0	0	1	2	2	2	1	1	4	4	4	1	4	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:47570606G>A	uc002pga.3	-	15	2957	c.2919C>T	c.(2917-2919)TTC>TTT	p.F973F	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	973							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CGGTGCGGGCGAAGCTGGGCT	0.677													29	122					0	0	0	0	A	47570606	A	A	47570606	2	1	276	1	0	0	0	0	0	0	0	1	17637	1049	37	1		1	ZC3H4	19	47570606	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	339425	47570606	11558377	1857	51746											
ZC3H4	23211	broad.mit.edu	37	chr19	47597293	47597293	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcactggggctgaaatccgaGtcatctgagaagtcagagaa	13	8	12	8	1	4	3	3	2	1	2	5	6	5	3	1	2	0	1	1	2	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:47597293G>A	uc002pga.3	-	4	464	c.426C>T	c.(424-426)GAC>GAT	p.D142D	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	142							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TGAAATCCGAGTCATCTGAGA	0.572													47	53					0	0	0	0	A	47597293	A	A	47597293	2	1	276	1	0	0	0	0	0	0	0	1	17637	1020	36	4		4	ZC3H4	19	47597293	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	26687	47597293	11531690	1858	51747											
GLTSCR2	29997	broad.mit.edu	37	chr19	48255849	48255849	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcttcctacaatccatcCtttgaagaccaccaggtaca	12	9	7	13	0	0	2	0	1	0	1	3	3	3	3	5	2	3	2	5	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:48255849C>T	uc002phm.2	+	6	774	c.750C>T	c.(748-750)TCC>TCT	p.S250S	GLTSCR2_uc002phk.2_Silent_p.S250S|GLTSCR2_uc002phl.2_Silent_p.S250S|GLTSCR2_uc010elj.2_Silent_p.S250S|GLTSCR2_uc010elk.1_RNA	NM_015710	NP_056525	Q9NZM5	GSCR2_HUMAN	glioma tumor suppressor candidate region gene 2	250						nucleolus				central_nervous_system(1)	1		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)		ACAATCCATCCTTTGAAGACC	0.612													12	34					0	0	0	0	T	48255849	T	T	48255849	2	4	276	1	0	0	0	0	0	0	0	1	6512	668	24	4		4	GLTSCR2	19	48255849	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	658556	48255849	10873134	1859	51748											
BCAT2	587	broad.mit.edu	37	chr19	49310269	49310270	+	Missense_Mutation	DNP	GG	AA	AA																															cctttcaccttgaaactggaGgaggcatatcttctgggacc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:49310269_49310270GG>AA	uc002pkr.2	-	2	123_124	c.86_87CC>TT	c.(85-87)TCC>TTT	p.S29F	BCAT2_uc002pkp.2_5'UTR|BCAT2_uc002pkq.3_5'UTR|BCAT2_uc002pks.2_5'UTR|BCAT2_uc002pkt.2_Intron|BCAT2_uc010emh.1_Missense_Mutation_p.S29F|BCAT2_uc010emi.1_Intron|BCAT2_uc002pku.1_5'UTR|BCAT2_uc010emj.1_RNA	NM_001190	NP_001181	O15382	BCAT2_HUMAN	branched chain aminotransferase 2, mitochondrial	29						mitochondrial matrix	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			ovary(1)	1		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.000366)|Epithelial(262;0.0195)|GBM - Glioblastoma multiforme(486;0.0224)	L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|Pyridoxal Phosphate(DB00114)	TGAAACTGGAGGAGGCATATCT	0.564													6	48					0	0	0	0	AA	49310270	AA	AA	49310269	3	1	276	1	0	0	0	0	1	0	0	0	1357	987	35	4	1131	4	BCAT2	19	49310269	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	1054420	49310269	9818714	1860	51749											
TULP2	7288	broad.mit.edu	37	chr19	49387077	49387077	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggagaatcacagtcattttCcgaggccccaggtatcctaa	11	9	10	11	1	2	1	2	0	0	1	4	3	4	1	4	3	0	1	4	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:49387077C>T	uc002pkz.2	-	11	1360	c.1209G>A	c.(1207-1209)CGG>CGA	p.R403R		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	403					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		CAGTCATTTTCCGAGGCCCCA	0.512													26	87					0	0	0	0	T	49387077	T	T	49387077	2	4	276	1	0	0	0	0	0	0	0	1	16842	842	30	2		2	TULP2	19	49387077	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	76808	49387077	9741906	1861	51750											
RUVBL2	10856	broad.mit.edu	37	chr19	49514284	49514284	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggagatcaagtcagaagtCcgtgagcagatcaatgccaa	14	6	13	8	1	3	4	3	1	0	3	4	5	4	4	2	2	2	1	2	2	4	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:49514284C>T	uc002plr.1	+	10	829	c.816C>T	c.(814-816)GTC>GTT	p.V272V	RUVBL2_uc002plq.1_Silent_p.V227V|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Silent_p.V227V|RUVBL2_uc010yac.1_Silent_p.V227V	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	272					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		AGTCAGAAGTCCGTGAGCAGA	0.622													6	37					0	0	0	0	T	49514284	T	T	49514284	2	4	276	1	0	0	0	0	0	0	0	1	13818	842	30	2		2	RUVBL2	19	49514284	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	127207	49514284	9614699	1862	51751											
CGB1	114335	broad.mit.edu	37	chr19	49539417	49539417	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggggcagtagccggcacaGatggtggtgttgacggtgat	7	9	19	6	2	0	3	0	2	0	1	0	3	0	3	1	6	1	4	1	6	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:49539417G>A	uc002plx.2	-	2	376	c.153C>T	c.(151-153)ATC>ATT	p.I51I	CGB_uc010yad.1_Intron|SNAR-G1_uc010emp.1_5'Flank	NM_033377	NP_203695	A6NKQ9	CGB1_HUMAN	chorionic gonadotropin, beta polypeptide 1	83						extracellular region	hormone activity				0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		AGCCGGCACAGATGGTGGTGT	0.687													23	141					0	0	0	0	A	49539417	A	A	49539417	2	1	276	1	0	0	0	0	0	0	0	1	3312	932	33	2		2	CGB1	19	49539417	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	25133	49539417	9589566	1863	51752											
SLC6A16	28968	broad.mit.edu	37	chr19	49812599	49812599	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aaggccaaattttgccccttCcaggagtagagtccggatga	11	9	11	10	1	0	2	0	1	0	1	2	4	2	4	5	3	1	1	5	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:49812599C>T	uc002pmz.2	-	6	1180	c.946G>A	c.(946-948)GAA>AAA	p.E316K	SLC6A16_uc002pna.2_Missense_Mutation_p.E316K|hsa-mir-4324|MI0015854_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	316						integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		TTTGCCCCTTCCAGGAGTAGA	0.507													6	37					0	0	0	0	T	49812599	T	T	49812599	3	4	276	1	0	0	0	0	1	0	0	0	14743	864	30	2	1292	2	SLC6A16	19	49812599	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	273182	49812599	9316384	1864	51753											
SLC6A16	28968	broad.mit.edu	37	chr19	49814231	49814231	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtaggcaaagcgccagagaCaagatggcttcatagagaag	15	5	14	7	1	1	3	1	0	0	3	1	5	1	3	1	3	1	3	1	3	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:49814231C>A	uc002pmz.2	-	2	608	c.374G>T	c.(373-375)TGT>TTT	p.C125F	SLC6A16_uc002pna.2_Missense_Mutation_p.C125F|hsa-mir-4324|MI0015854_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	125	Cytoplasmic (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		GCGCCAGAGACAAGATGGCTT	0.537													23	67					2.21704e-12	2.27535e-12	1	0	A	49814231	A	A	49814231	3	1	276	1	0	0	0	0	1	0	0	0	14743	478	17	4	1880	4	SLC6A16	19	49814231	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1632	49814231	9314752	1865	51754											
PRR12	57479	broad.mit.edu	37	chr19	50099247	50099247	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggtggctggggacccagctCcctgggaggcggcggtgagg	4	5	22	10	2	0	1	0	1	0	0	1	3	1	3	2	9	1	2	2	9	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:50099247C>T	uc002poo.3	+	4	1655	c.1655C>T	c.(1654-1656)TCC>TTC	p.S552F		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGACCCAGCTCCCTGGGAGGC	0.711													5	57					0	0	0	0	T	50099247	T	T	50099247	3	4	276	1	0	0	0	0	1	0	0	0	12646	855	30	2	1669	2	PRR12	19	50099247	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	285016	50099247	9029736	1866	51755											
TBC1D17	79735	broad.mit.edu	37	chr19	50390808	50390808	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caagagggaattccccttccCggatgtccttcggctgtggg	6	10	13	12	2	0	1	0	0	0	1	4	3	3	3	4	4	0	1	4	4	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:50390808C>T	uc002pqo.2	+	14	1672	c.1520C>T	c.(1519-1521)CCG>CTG	p.P507L	TBC1D17_uc010ybg.1_Missense_Mutation_p.P474L|TBC1D17_uc002pqp.2_Missense_Mutation_p.P158L|TBC1D17_uc002pqr.2_Missense_Mutation_p.P158L|TBC1D17_uc002pqs.2_RNA|IL4I1_uc002pqv.1_3'UTR|IL4I1_uc010eno.1_3'UTR|IL4I1_uc002pqw.1_3'UTR	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	507	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		TTCCCCTTCCCGGATGTCCTT	0.632													13	30					0	0	0	0	T	50390808	T	T	50390808	3	4	276	1	0	0	0	0	1	0	0	0	15672	652	23	1	1574	1	TBC1D17	19	50390808	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	291561	50390808	8738175	1867	51756											
ATF5	22809	broad.mit.edu	37	chr19	50434207	50434207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atgggaaactccccccggccCctgcccccctggctccctat	5	7	8	21	1	0	0	0	0	0	0	2	1	2	1	9	3	2	1	9	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:50434207C>T	uc010enq.1	+	3	667	c.100C>T	c.(100-102)CCT>TCT	p.P34S	IL4I1_uc002pqv.1_5'Flank|IL4I1_uc010eno.1_5'Flank|IL4I1_uc002pqw.1_5'Flank|IL4I1_uc002pqu.1_5'Flank|NUP62_uc002pqx.2_5'Flank|NUP62_uc002pqy.2_5'Flank|NUP62_uc002pqz.2_5'Flank|NUP62_uc002pra.2_5'Flank|NUP62_uc002prb.2_5'Flank|NUP62_uc002prc.2_5'Flank|ATF5_uc002prd.2_Missense_Mutation_p.P34S	NM_012068	NP_036200	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5	34					regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			skin(2)	2		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCCCCCGGCCCCTGCCCCCCT	0.687													3	14					0	0	0	0	T	50434207	T	T	50434207	3	4	276	1	0	0	0	0	1	0	0	0	1085	623	22	4	102	4	ATF5	19	50434207	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	43399	50434207	8694776	1868	51757											
MYH14	79784	broad.mit.edu	37	chr19	50780155	50780155	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gagcagctggagcaggcccgGagggtgggttggggcagggg	6	4	24	7	1	0	0	0	0	0	0	0	3	0	2	1	9	3	5	1	9	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:50780155G>A	uc002prr.1	+	27	3746	c.3699G>A	c.(3697-3699)CGG>CGA	p.R1233R	MYH14_uc010enu.1_Silent_p.R1274R|MYH14_uc002prq.1_Silent_p.R1241R	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1233	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		AGCAGGCCCGGagggtgggtt	0.502													5	28					0	0	0	0	A	50780155	A	A	50780155	2	1	276	1	0	0	0	0	0	0	0	1	10086	1161	41	2		2	MYH14	19	50780155	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	345948	50780155	8348828	1869	51758											
SPIB	6689	broad.mit.edu	37	chr19	50926874	50926874	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttccgcagaccctggttcccCcggcatatgccccgtacccc	5	8	8	20	3	0	1	0	0	0	1	2	1	2	1	8	2	2	4	8	2	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:50926874C>T	uc002psd.2	+	5	377	c.352C>T	c.(352-354)CCG>TCG	p.P118S	SPIB_uc002pse.2_Missense_Mutation_p.P118S|SPIB_uc010ycc.1_Missense_Mutation_p.P27S	NM_003121	NP_003112	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	118					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			lung(1)|kidney(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CCTGGTTCCCCCGGCATATGC	0.647													6	23					0	0	0	0	T	50926874	T	T	50926874	3	4	276	1	0	0	0	0	1	0	0	0	15116	623	22	4	370	4	SPIB	19	50926874	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	146719	50926874	8202109	1870	51759											
MYBPC2	4606	broad.mit.edu	37	chr19	50957535	50957535	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgcagatgtcccagacccCccggaggctgtgcgcatcac	7	6	11	17	2	1	2	1	0	0	2	2	3	2	3	5	2	2	3	5	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:50957535C>T	uc002psf.2	+	18	1974	c.1923C>T	c.(1921-1923)CCC>CCT	p.P641P		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	641	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		TCCCAGACCCCCCGGAGGCTG	0.652													4	61					0	0	0	0	T	50957535	T	T	50957535	2	4	276	1	0	0	0	0	0	0	0	1	10065	610	22	4		4	MYBPC2	19	50957535	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	30661	50957535	8171448	1871	51760											
LRRC4B	94030	broad.mit.edu	37	chr19	51051874	51051874	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggacctcggccaggtctctCcgtgtgcagatcacccggct	5	8	13	15	3	2	1	1	0	1	1	5	2	3	2	4	4	1	2	4	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:51051874C>T	uc002pss.2	-	2	359	c.222G>A	c.(220-222)CGG>CGA	p.R74R		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	74	Extracellular (Potential).|LRRNT.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		CCAGGTCTCTCCGTGTGCAGA	0.706													3	12					0	0	0	0	T	51051874	T	T	51051874	2	4	276	1	0	0	0	0	0	0	0	1	9057	842	30	2		2	LRRC4B	19	51051874	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	94339	51051874	8077109	1872	51761											
SYT3	84258	broad.mit.edu	37	chr19	51133093	51133094	+	Missense_Mutation	DNP	GG	AA	AA																															gcaggtagatcttgacgtagGggtctgagaagccgttggag																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:51133093_51133094GG>AA	uc002pst.2	-	3	1643_1644	c.1009_1010CC>TT	c.(1009-1011)CCC>TTC	p.P337F	SYT3_uc002psv.2_Missense_Mutation_p.P337F|SYT3_uc010ycd.1_Missense_Mutation_p.P337F	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	337	C2 1.|Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CTTGACGTAGGGGTCTGAGAAG	0.465													14	110					0	0	0	0	AA	51133094	AA	AA	51133093	3	1	276	1	0	0	0	0	1	0	0	0	15541	1232	43	4	786	4	SYT3	19	51133093	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	81219	51133093	7995890	1873	51762											
SYT3	84258	broad.mit.edu	37	chr19	51133335	51133335	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttttcctcgcctccaggcagGggtaagggcagggcaggtgg	6	8	17	10	1	0	0	0	0	0	0	3	0	2	0	3	7	0	4	3	7	1	3	rs144661464	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:51133335G>A	uc002pst.2	-	3	1402	c.768C>T	c.(766-768)CCC>CCT	p.P256P	SYT3_uc002psv.2_Silent_p.P256P|SYT3_uc010ycd.1_Silent_p.P256P	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	256	Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CTCCAGGCAGGGGTAAGGGCA	0.677													10	53					0	0	0	0	A	51133335	A	A	51133335	2	1	276	1	0	0	0	0	0	0	0	1	15541	1219	43	4		4	SYT3	19	51133335	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	242	51133335	7995648	1874	51763											
KLK1	3816	broad.mit.edu	37	chr19	51322539	51322539	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttattgggggtgccacaagGgacgtagccccatgatgtga	9	9	14	9	1	0	2	0	2	0	0	0	3	0	3	3	3	2	1	3	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:51322539G>C	uc002ptk.1	-	5	739	c.700C>G	c.(700-702)CCT>GCT	p.P234A	KLK1_uc010ycg.1_RNA	NM_002257	NP_002248	P06870	KLK1_HUMAN	kallikrein 1 preproprotein	234	Peptidase S1.				proteolysis	nucleus	serine-type endopeptidase activity				0		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGCCACAAGGGACGTAGCCC	0.582													19	96					0	0	0	0	C	51322539	C	C	51322539	3	2	276	1	0	0	0	0	1	0	0	0	8436	1232	43	4	92	4	KLK1	19	51322539	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	189204	51322539	7806444	1875	51764											
KLK3	354	broad.mit.edu	37	chr19	51361525	51361525	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acccaggagccagcactgggGaccacctgctacgcctcagg	9	4	12	16	1	1	0	1	0	0	0	1	2	1	2	5	4	4	2	5	4	1	1	rs147547638	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:51361525G>A	uc002pts.1	+	3	488	c.447G>A	c.(445-447)GGG>GGA	p.G149G	KLK3_uc010ycj.1_Intron|KLK3_uc002ptr.1_Silent_p.G106G|KLK3_uc010eof.1_RNA	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	149	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		CAGCACTGGGGACCACCTGCT	0.483													29	37					0	0	0	0	A	51361525	A	A	51361525	2	1	276	1	0	0	0	0	0	0	0	1	8444	1161	41	2		2	KLK3	19	51361525	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	38986	51361525	7767458	1876	51765											
KLK13	26085	broad.mit.edu	37	chr19	51563854	51563854	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccattggtgttgagaacCttggaagactcctgggagac	9	10	13	9	0	0	3	0	1	0	3	2	6	2	4	3	3	1	1	3	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:51563854C>T	uc002pvn.2	-	2	118	c.75G>A	c.(73-75)AAG>AAA	p.K25K	KLK13_uc002pvl.2_RNA|KLK13_uc002pvm.2_RNA|KLK13_uc002pvo.2_RNA|KLK13_uc002pvp.2_RNA|KLK13_uc010eon.2_Silent_p.K25K|KLK13_uc002pvq.2_RNA|KLK13_uc010eoo.2_Intron|KLK13_uc002pvr.2_Silent_p.K25K	NM_015596	NP_056411	Q9UKR3	KLK13_HUMAN	kallikrein 13 precursor	25					proteolysis		protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		TGTTGAGAACCTTGGAAGACT	0.577													64	109					0	0	0	0	T	51563854	T	T	51563854	2	4	276	1	0	0	0	0	0	0	0	1	8440	680	24	4		4	KLK13	19	51563854	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	202329	51563854	7565129	1877	51766											
SIGLEC10	89790	broad.mit.edu	37	chr19	51918579	51918579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggaggggctcagaacctgtcCcctctgggtccagctcagcc	6	7	13	15	0	3	1	2	0	1	1	5	2	5	2	5	4	3	2	5	4	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:51918579C>T	uc002pwo.2	-	7	1802	c.1186G>A	c.(1186-1188)GGA>AGA	p.G396R	SIGLEC10_uc002pwp.2_Missense_Mutation_p.G338R|SIGLEC10_uc002pwq.2_Missense_Mutation_p.G338R|SIGLEC10_uc002pwr.2_Missense_Mutation_p.G396R|SIGLEC10_uc010ycy.1_Missense_Mutation_p.G306R|SIGLEC10_uc010ycz.1_Missense_Mutation_p.G348R|SIGLEC10_uc010eow.2_Missense_Mutation_p.G208R|SIGLEC10_uc002pws.1_Missense_Mutation_p.G232R	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	396	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AGAACCTGTCCCCTCTGGGTC	0.657													19	42					0	0	0	0	T	51918579	T	T	51918579	3	4	276	1	0	0	0	0	1	0	0	0	14371	632	22	4	927	4	SIGLEC10	19	51918579	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	354725	51918579	7210404	1878	51767											
SIGLEC10	89790	broad.mit.edu	37	chr19	51919992	51919992	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtccacatggcaggtgaggtCggtgttgtggtcctggggtc	4	11	18	8	1	0	1	0	1	0	0	4	1	2	1	2	7	0	2	2	7	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:51919992C>T	uc002pwo.2	-	3	1250	c.634G>A	c.(634-636)GAC>AAC	p.D212N	SIGLEC10_uc002pwp.2_Missense_Mutation_p.D154N|SIGLEC10_uc002pwq.2_Missense_Mutation_p.D154N|SIGLEC10_uc002pwr.2_Missense_Mutation_p.D212N|SIGLEC10_uc010ycy.1_Missense_Mutation_p.D212N|SIGLEC10_uc010ycz.1_Missense_Mutation_p.D164N|SIGLEC10_uc010eow.2_5'UTR|SIGLEC10_uc002pws.1_Missense_Mutation_p.D138N	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	212	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CAGGTGAGGTCGGTGTTGTGG	0.632													26	32					0	0	0	0	T	51919992	T	T	51919992	3	4	276	1	0	0	0	0	1	0	0	0	14371	884	31	1	1495	1	SIGLEC10	19	51919992	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1413	51919992	7208991	1879	51768											
FPR2	2358	broad.mit.edu	37	chr19	52272633	52272633	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taaatccagccgtcccttacGggtcctcactgctgtggtgg	6	11	11	13	2	1	0	1	0	0	0	4	0	4	0	4	3	3	1	4	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:52272633G>A	uc002pxr.2	+	2	767	c.722G>A	c.(721-723)CGG>CAG	p.R241Q	FPR2_uc002pxs.3_Missense_Mutation_p.R241Q|FPR2_uc010epf.2_Missense_Mutation_p.R241Q	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	241	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						CGTCCCTTACGGGTCCTCACT	0.493													11	64					0	0	0	0	A	52272633	A	A	52272633	3	1	276	1	0	0	0	0	1	0	0	0	6073	1116	39	1	724	1	FPR2	19	52272633	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	352641	52272633	6856350	1880	51769											
FPR3	2359	broad.mit.edu	37	chr19	52327767	52327767	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctttcttcatctgttggttcCcttatgaactaattggcatt	7	19	6	9	0	3	1	1	1	2	0	4	1	4	1	1	2	1	3	1	2	3	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:52327767C>T	uc002pxt.1	+	2	950	c.766C>T	c.(766-768)CCT>TCT	p.P256S		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	256	Helical; Name=6; (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						CTGTTGGTTCCCTTATGAACT	0.423													16	95					0	0	0	0	T	52327767	T	T	52327767	3	4	276	1	0	0	0	0	1	0	0	0	6074	623	22	4	768	4	FPR3	19	52327767	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	55134	52327767	6801216	1881	51770											
ZNF577	84765	broad.mit.edu	37	chr19	52376138	52376138	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agttttctcatgtttaatgaGgactgacatgtgggcaaagg	11	13	12	5	0	1	2	1	2	1	0	2	3	1	3	0	3	0	3	0	3	2	4	rs139133866		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:52376138G>A	uc010yde.1	-	7	1496	c.1105C>T	c.(1105-1107)CTC>TTC	p.L369F	ZNF577_uc010ydd.1_Intron|ZNF577_uc002pxx.3_Missense_Mutation_p.L310F|ZNF577_uc002pxv.2_Missense_Mutation_p.L362F|ZNF577_uc002pxw.2_Missense_Mutation_p.L303F	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	369	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGTTTAATGAGGACTGACATG	0.448													35	99					0	0	0	0	A	52376138	A	A	52376138	3	1	276	1	0	0	0	0	1	0	0	0	18076	1000	35	4	356	4	ZNF577	19	52376138	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	48371	52376138	6752845	1882	51771											
ZNF615	284370	broad.mit.edu	37	chr19	52496734	52496734	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtttctctcctgtatgagttCgttgatgtcccattagccgg	5	16	10	10	2	1	2	0	2	1	0	5	2	3	2	3	1	1	4	3	1	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:52496734C>T	uc002pye.1	-	6	1887	c.1595G>A	c.(1594-1596)CGA>CAA	p.R532Q	ZNF615_uc002pyf.1_Missense_Mutation_p.R543Q|ZNF615_uc002pyg.1_Missense_Mutation_p.R424Q|ZNF615_uc002pyh.1_Missense_Mutation_p.R543Q|ZNF615_uc010epi.1_Missense_Mutation_p.R539Q|ZNF615_uc010ydg.1_Missense_Mutation_p.R537Q	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	532	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGTATGAGTTCGTTGATGTCC	0.443													25	160					0	0	0	0	T	52496734	T	T	52496734	3	4	276	1	0	0	0	0	1	0	0	0	18107	884	31	1	604	1	ZNF615	19	52496734	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	120596	52496734	6632249	1883	51772											
ZNF578	147660	broad.mit.edu	37	chr19	53015077	53015077	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataattcatactggagagaaAccttacaagtgtaatgagtg	16	11	9	5	0	1	2	1	1	0	1	1	4	1	3	1	1	3	1	1	1	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:53015077A>G	uc002pzp.3	+	6	1687	c.1443A>G	c.(1441-1443)AAA>AAG	p.K481K		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		CTGGAGAGAAACCTTACAAGT	0.388													30	90					0	0	0	0	G	53015077	G	G	53015077	2	3	276	1	0	0	0	0	0	0	0	1	18077	40	2	5		5	ZNF578	19	53015077	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	518343	53015077	6113906	1884	51773											
ZNF808	388558	broad.mit.edu	37	chr19	53050850	53050850	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcacagagggctttgtacaGggaagtgatgttggagaact	11	10	15	5	0	0	3	0	1	0	2	0	5	0	4	0	3	3	4	0	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:53050850G>T	uc010epq.1	+	4	326	c.149G>T	c.(148-150)AGG>ATG	p.R50M	ZNF808_uc002pzq.2_Intron	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	50	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		GCTTTGTACAGGGAAGTGATG	0.483													27	240					1.77063e-15	1.82905e-15	1	0	T	53050850	T	T	53050850	3	4	276	1	0	0	0	0	1	0	0	0	18240	1000	35	4	155	4	ZNF808	19	53050850	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	35773	53050850	6078133	1885	51774											
ZNF320	162967	broad.mit.edu	37	chr19	53383907	53383907	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaaacaattgtctccaaaaGgaattttctgatgttctgca	13	14	7	7	0	3	2	0	2	3	0	4	3	3	3	1	1	2	2	1	1	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:53383907G>A	uc002qag.2	-	4	1663	c.1472C>T	c.(1471-1473)CCT>CTT	p.P491L	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.P437L|ZNF320_uc002qai.2_Missense_Mutation_p.P491L	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	491	C2H2-type 12; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		GTCTCCAAAAGGAATTTTCTG	0.393													9	87					0	0	0	0	A	53383907	A	A	53383907	3	1	276	1	0	0	0	0	1	0	0	0	17906	1000	35	4	61	4	ZNF320	19	53383907	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	333057	53383907	5745076	1886	51775											
ZNF665	79788	broad.mit.edu	37	chr19	53668984	53668984	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctctccagtatgaattctCtgatgacctgcaaggtttga	9	15	8	9	0	2	4	0	4	2	0	5	4	3	4	2	1	1	3	2	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:53668984C>T	uc010eqm.1	-	4	859	c.759G>A	c.(757-759)CAG>CAA	p.Q253Q		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	188	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TATGAATTCTCTGATGACCTG	0.403													26	172					0	0	0	0	T	53668984	T	T	53668984	2	4	276	1	0	0	0	0	0	0	0	1	18140	912	32	2		2	ZNF665	19	53668984	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	285077	53668984	5459999	1887	51776											
ZNF765	91661	broad.mit.edu	37	chr19	53911563	53911563	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgatatatgtggcaaggtctTtaattcgaagcgatacgttg	11	13	11	6	4	1	0	0	0	1	0	2	3	1	0	0	2	2	2	0	2	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:53911563T>A	uc010ydx.1	+	6	1082	c.755T>A	c.(754-756)TTT>TAT	p.F252Y	ZNF765_uc002qbm.2_Missense_Mutation_p.F252Y|ZNF765_uc002qbn.2_Intron	NM_001040185	NP_001035275	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	252	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00379)		GGCAAGGTCTTTAATTCGAAG	0.403													16	137					0	0	0	0	A	53911563	A	A	53911563	3	1	276	1	0	0	0	0	1	0	0	0	18206	1841	64	5	765	5	ZNF765	19	53911563	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	242579	53911563	5217420	1888	51777											
NLRP12	91662	broad.mit.edu	37	chr19	54327227	54327227	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagagccaacctccaggcctCctctggcccgaagtgggtga	8	6	13	14	1	1	2	0	1	1	1	3	4	3	2	6	3	2	0	6	3	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:54327227C>T	uc002qch.3	-	1	422	c.202G>A	c.(202-204)GAG>AAG	p.E68K	NLRP12_uc002qci.3_Missense_Mutation_p.E68K|NLRP12_uc002qcj.3_Missense_Mutation_p.E68K|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.E68K	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	68	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CTCCAGGCCTCCTCTGGCCCG	0.617													26	156					0	0	0	0	T	54327227	T	T	54327227	3	4	276	1	0	0	0	0	1	0	0	0	10528	864	30	2	3119	2	NLRP12	19	54327227	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	415664	54327227	4801756	1889	51778											
PRKCG	5582	broad.mit.edu	37	chr19	54394978	54394978	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	accccaatggtctctctgatCcctatgtgaaactgaagctc	10	11	7	13	0	2	3	0	3	2	0	5	3	3	3	3	1	2	1	3	1	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:54394978C>T	uc002qcq.1	+	6	862	c.580C>T	c.(580-582)CCC>TCC	p.P194S	PRKCG_uc010eqz.1_Missense_Mutation_p.P194S|PRKCG_uc010yef.1_Missense_Mutation_p.P194S|PRKCG_uc010yeg.1_Missense_Mutation_p.P194S|PRKCG_uc010yeh.1_Missense_Mutation_p.P81S	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	194	C2.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TCTCTCTGATCCCTATGTGAA	0.532													74	164					0	0	0	0	T	54394978	T	T	54394978	3	4	276	1	0	0	0	0	1	0	0	0	12574	855	30	2	602	2	PRKCG	19	54394978	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	67751	54394978	4734005	1890	51779											
CACNG7	59284	broad.mit.edu	37	chr19	54444857	54444857	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccttcgccgcttcctccttCctactcaaagaggtgacgtc	6	11	8	16	3	1	2	1	1	0	1	6	2	4	2	5	1	1	1	5	1	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:54444857C>T	uc002qcr.1	+	4	573	c.558C>T	c.(556-558)TTC>TTT	p.F186F	CACNG7_uc010era.1_Silent_p.F186F	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	186	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		CTTCCTCCTTCCTACTCAAAG	0.468													39	108					0	0	0	0	T	54444857	T	T	54444857	2	4	276	1	0	0	0	0	0	0	0	1	2574	854	30	2		2	CACNG7	19	54444857	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	49879	54444857	4684126	1891	51780											
LILRB5	10990	broad.mit.edu	37	chr19	54760510	54760510	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgtctcttccgggcccatGggagtccctccttatccaga	5	12	9	15	1	2	1	0	0	2	1	7	2	6	2	5	2	0	0	5	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:54760510G>A	uc002qex.2	-	3	308	c.197C>T	c.(196-198)CCA>CTA	p.P66L	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.P66L|LILRB5_uc002qey.2_Missense_Mutation_p.P66L|LILRB5_uc002qez.2_Missense_Mutation_p.P66L|LILRB5_uc002qfa.1_Missense_Mutation_p.P56L|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	66	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCGGGCCCATGGGAGTCCCTC	0.617													95	118					0	0	0	0	A	54760510	A	A	54760510	3	1	276	1	0	0	0	0	1	0	0	0	8835	1348	47	4	1622	4	LILRB5	19	54760510	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	315653	54760510	4368473	1892	51781											
LILRA3	11026	broad.mit.edu	37	chr19	54802615	54802615	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagttggcctgggagagccCagcctggggctgccggccag	6	5	18	12	1	0	1	0	0	0	1	0	3	0	1	5	5	3	2	5	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:54802615C>T	uc002qfd.2	-	5	891	c.826G>A	c.(826-828)GGG>AGG	p.G276R	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Missense_Mutation_p.G212R	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	276	Ig-like C2-type 3.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGAGAGCCCAGCCTGGGGC	0.642													15	100					0	0	0	0	T	54802615	T	T	54802615	3	4	276	1	0	0	0	0	1	0	0	0	8827	594	21	4	505	4	LILRA3	19	54802615	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	42105	54802615	4326368	1893	51782											
LILRA4	23547	broad.mit.edu	37	chr19	54848307	54848307	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgccccctccttggtcagaaGgaaagtgaacatcgggtccc	9	8	11	13	1	1	2	1	1	0	1	4	3	3	3	4	3	2	0	4	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:54848307G>A	uc002qfj.2	-	6	1117	c.1060C>T	c.(1060-1062)CTT>TTT	p.L354F	LILRA4_uc002qfi.2_Missense_Mutation_p.L288F	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	354	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TTGGTCAGAAGGAAAGTGAAC	0.587													22	151					0	0	0	0	A	54848307	A	A	54848307	3	1	276	1	0	0	0	0	1	0	0	0	8828	1000	35	4	451	4	LILRA4	19	54848307	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	45692	54848307	4280676	1894	51783											
LENG9	94059	broad.mit.edu	37	chr19	54973853	54973853	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggctgcaacactaaggcggGcccttttgtcctcgggccag	6	8	14	13	2	0	0	0	0	0	0	2	0	1	0	3	4	2	2	3	4	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:54973853G>A	uc010yez.1	-	1	1042	c.923C>T	c.(922-924)GCC>GTC	p.A308V		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	308					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		ACTAAGGCGGGCCCTTTTGTC	0.667													9	47					0	0	0	0	A	54973853	A	A	54973853	3	1	276	1	0	0	0	0	1	0	0	0	8765	1203	42	4	586	4	LENG9	19	54973853	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	125546	54973853	4155130	1895	51784											
LILRA2	11027	broad.mit.edu	37	chr19	55086387	55086388	+	Missense_Mutation	DNP	CC	TT	TT																															gtggtcctgggccatcttctCcgtgggccccgtgagcccga																								rs143437645		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:55086387_55086388CC>TT	uc002qgg.3	+	4	631_632	c.542_543CC>TT	c.(541-543)TCC>TTT	p.S181F	LILRA2_uc010ern.2_Missense_Mutation_p.S181F|LILRA2_uc002qgf.2_Missense_Mutation_p.S181F|LILRA2_uc010yfe.1_Missense_Mutation_p.S181F|LILRA2_uc010yff.1_Missense_Mutation_p.S169F|LILRA2_uc010ero.2_Missense_Mutation_p.S169F|LILRA2_uc010yfg.1_Missense_Mutation_p.S181F	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	181	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		GCCATCTTCTCCGTGGGCCCCG	0.569													66	151					0	0	0	0	TT	55086388	TT	TT	55086387	3	4	276	1	0	0	0	0	1	0	0	0	8826	855	30	2	556	2	LILRA2	19	55086387	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	112534	55086387	4042596	1896	51785											
LILRA1	11024	broad.mit.edu	37	chr19	55106754	55106754	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtcccgggccatcttctCtgtgggccccgtgagcccga	3	9	14	15	3	2	1	0	1	2	0	4	2	3	1	5	3	1	0	5	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:55106754C>T	uc002qgh.1	+	5	730	c.548C>T	c.(547-549)TCT>TTT	p.S183F	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.S183F	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	183	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GCCATCTTCTCTGTGGGCCCC	0.567													107	144					0	0	0	0	T	55106754	T	T	55106754	3	4	276	1	0	0	0	0	1	0	0	0	8825	913	32	2	562	2	LILRA1	19	55106754	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	20367	55106754	4022229	1897	51786											
KIR3DL1	3811	broad.mit.edu	37	chr19	55340822	55340822	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcctcttcttccaggtaaccCcagacacctgcacattctga	9	11	5	16	0	3	2	0	1	3	1	5	2	5	2	5	1	2	2	5	1	1	4	rs1130462		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:55340822C>T	uc002qhk.3	+	7	1070	c.1007C>T	c.(1006-1008)CCC>CTC	p.P336L	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.P261L|KIR3DL1_uc010esf.2_Missense_Mutation_p.P241L|KIR3DL1_uc010yfo.1_Missense_Mutation_p.P278L|KIR3DL1_uc002qhl.3_Intron	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	336	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		CCAGGTAACCCCAGACACCTG	0.333													102	60					0	0	0	0	T	55340822	T	T	55340822	3	4	276	1	0	0	0	0	1	0	0	0	8359	623	22	4	1033	4	KIR3DL1	19	55340822	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	234068	55340822	3788161	1898	51787											
NLRP2	55655	broad.mit.edu	37	chr19	55493546	55493547	+	Nonsense_Mutation	DNP	CA	AC	AC																															aaagacaaagacaataggtgCaggtatatattgaagacgaa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:55493546_55493547CA>AC	uc002qij.2	+	6	566_567	c.480_481CA>AC	c.(478-483)TGCAGG>TGACGG	p.C160*	NLRP2_uc010yfp.1_Nonsense_Mutation_p.C137*|NLRP2_uc010esn.2_Nonsense_Mutation_p.C136*|NLRP2_uc010eso.2_Nonsense_Mutation_p.C157*|NLRP2_uc010esp.2_Nonsense_Mutation_p.C138*	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	160					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ACAATAGGTGCAGGTATATATT	0.45													131	337					0	0	0	0	AC	55493547	AC	AC	55493546	4	1	276	1	0	0	0	0	0	1	0	0	10531	718	25	4	498	4	NLRP2	19	55493546	Nonsense_Mutation	DNP	CA	TCGA-D6-6516-01A-11D-1870-08	152724	55493546	3635437	1899	51788											
TNNI3	7137	broad.mit.edu	37	chr19	55667649	55667649	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgccccttctctccgcgccGctcctccgcctctcgctcca	1	9	7	24	6	2	0	0	0	2	0	8	0	6	0	8	0	0	2	8	0	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:55667649G>A	uc002qjg.3	-	5	202	c.202C>T	c.(202-204)CGG>TGG	p.R68W	TNNI3_uc010yft.1_Missense_Mutation_p.R60W	NM_000363	NP_000354	P19429	TNNI3_HUMAN	troponin I, cardiac	68	Involved in binding TNC.				cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			lung(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		TCTCCGCGCCGCTCCTCCGCC	0.682													4	44					0	0	0	0	A	55667649	A	A	55667649	3	1	276	1	0	0	0	0	1	0	0	0	16394	1086	38	1	446	1	TNNI3	19	55667649	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	174103	55667649	3461334	1900	51789											
FIZ1	84922	broad.mit.edu	37	chr19	56103957	56103957	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtagcactcgtggcggaaGaacttgccgcactccaggca	10	6	13	12	3	0	1	0	0	0	1	2	2	1	2	2	4	3	4	2	4	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56103957G>A	uc002qli.3	-	3	1440	c.1350C>T	c.(1348-1350)TTC>TTT	p.F450F	FIZ1_uc002qlj.3_Silent_p.F450F	NM_032836	NP_116225	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	450	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CGTGGCGGAAGAACTTGCCGC	0.662													3	21					0	0	0	0	A	56103957	A	A	56103957	2	1	276	1	0	0	0	0	0	0	0	1	5932	933	33	2		2	FIZ1	19	56103957	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	436308	56103957	3025026	1901	51790											
NLRP9	338321	broad.mit.edu	37	chr19	56244136	56244136	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agtttatttcaaggtcttctCccctctctagcctctgtttc	5	18	5	13	0	5	0	1	0	4	0	8	0	5	0	3	1	1	2	3	1	3	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56244136C>T	uc002qly.2	-	2	1089	c.1061G>A	c.(1060-1062)GGA>GAA	p.G354E		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	354	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AAGGTCTTCTCCCCTCTCTAG	0.413													51	83					0	0	0	0	T	56244136	T	T	56244136	3	4	276	1	0	0	0	0	1	0	0	0	10538	855	30	2	1946	2	NLRP9	19	56244136	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	140179	56244136	2884847	1902	51791											
NLRP11	204801	broad.mit.edu	37	chr19	56297047	56297047	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	catggctgcagacattctggGaaatttgaaaaacatgtaat	15	11	9	6	0	1	2	0	1	1	1	1	3	1	3	0	2	2	3	0	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56297047G>A	uc010ygf.1	-	12	3757	c.3046C>T	c.(3046-3048)CCC>TCC	p.P1016S	NLRP11_uc002qlz.2_Missense_Mutation_p.P863S|NLRP11_uc002qmb.2_Missense_Mutation_p.P917S|NLRP11_uc002qmc.2_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	1016							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		GACATTCTGGGAAATTTGAAA	0.373													24	99					0	0	0	0	A	56297047	A	A	56297047	3	1	276	1	0	0	0	0	1	0	0	0	10527	1174	41	2	59	2	NLRP11	19	56297047	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	52911	56297047	2831936	1903	51792											
NLRP11	204801	broad.mit.edu	37	chr19	56319270	56319270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagggctttagacagaatcCtttctgaaataccattaagg	13	11	8	9	0	1	3	0	1	1	2	2	3	2	3	3	2	1	1	3	2	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56319270C>T	uc010ygf.1	-	6	2663	c.1952G>A	c.(1951-1953)AGG>AAG	p.R651K	NLRP11_uc002qlz.2_Intron|NLRP11_uc002qmb.2_Missense_Mutation_p.R552K|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	651	LRR 2.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		AGACAGAATCCTTTCTGAAAT	0.438													21	170					0	0	0	0	T	56319270	T	T	56319270	3	4	276	1	0	0	0	0	1	0	0	0	10527	681	24	4	1177	4	NLRP11	19	56319270	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	22223	56319270	2809713	1904	51793											
NLRP11	204801	broad.mit.edu	37	chr19	56320316	56320316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgtcttcacaaattcttcttCccgattctcatagagacagt	10	14	5	12	2	5	1	2	0	4	1	7	3	6	1	1	0	0	0	1	0	2	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56320316C>T	uc010ygf.1	-	5	2371	c.1660G>A	c.(1660-1662)GAA>AAA	p.E554K	NLRP11_uc002qlz.2_Missense_Mutation_p.E455K|NLRP11_uc002qmb.2_Missense_Mutation_p.E455K|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	554							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		AATTCTTCTTCCCGATTCTCA	0.423													32	182					0	0	0	0	T	56320316	T	T	56320316	3	4	276	1	0	0	0	0	1	0	0	0	10527	864	30	2	1473	2	NLRP11	19	56320316	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1046	56320316	2808667	1905	51794											
NLRP4	147945	broad.mit.edu	37	chr19	56363573	56363573	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agcttgaactcaagcagattCcctggactgaggtcaaaaaa	15	8	9	9	0	2	3	2	2	0	1	3	4	3	4	1	2	3	2	1	2	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56363573C>T	uc002qmd.3	+	2	549	c.127C>T	c.(127-129)CCC>TCC	p.P43S		NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	43	DAPIN.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CAAGCAGATTCCCTGGACTGA	0.413													52	86					0	0	0	0	T	56363573	T	T	56363573	3	4	276	1	0	0	0	0	1	0	0	0	10533	855	30	2	129	2	NLRP4	19	56363573	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	43257	56363573	2765410	1906	51795											
NLRP4	147945	broad.mit.edu	37	chr19	56370046	56370046	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggttgttgacgctgacatCcctgcgctgctgggcaccaa	6	9	14	12	2	0	2	0	2	0	0	1	2	1	2	2	3	2	6	2	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56370046C>T	uc002qmd.3	+	3	1709	c.1287C>T	c.(1285-1287)ATC>ATT	p.I429I	NLRP4_uc002qmf.2_Silent_p.I354I|NLRP4_uc010etf.2_Silent_p.I260I	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	429	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ACGCTGACATCCCTGCGCTGC	0.557													55	131					0	0	0	0	T	56370046	T	T	56370046	2	4	276	1	0	0	0	0	0	0	0	1	10533	845	30	2		2	NLRP4	19	56370046	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6473	56370046	2758937	1907	51796											
NLRP13	126204	broad.mit.edu	37	chr19	56423283	56423283	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgaaaaagtcgtagaatgtGaaattggagagaggcacttt	15	10	13	3	1	0	4	0	2	0	2	1	6	0	5	0	2	0	2	0	2	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56423283G>A	uc010ygg.1	-	5	1925	c.1900C>T	c.(1900-1902)CAC>TAC	p.H634Y		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	634							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CGTAGAATGTGAAATTGGAGA	0.408													47	70					0	0	0	0	A	56423283	A	A	56423283	3	1	276	1	0	0	0	0	1	0	0	0	10529	1290	45	2	1257	2	NLRP13	19	56423283	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	53237	56423283	2705700	1908	51797											
NLRP5	126206	broad.mit.edu	37	chr19	56515092	56515092	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcttttaagtcttgtcactCtttccacaggtcctacttgc	6	17	5	13	0	4	0	1	0	3	0	6	0	6	0	2	1	2	0	2	1	2	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56515092C>T	uc002qmj.2	+	2	73	c.73C>T	c.(73-75)CTT>TTT	p.L25F	NLRP5_uc002qmi.2_Missense_Mutation_p.L25F	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	25						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TCTTGTCACTCTTTCCACAGG	0.408													38	103					0	0	0	0	T	56515092	T	T	56515092	3	4	276	1	0	0	0	0	1	0	0	0	10534	913	32	2	79	2	NLRP5	19	56515092	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	91809	56515092	2613891	1909	51798											
GALP	85569	broad.mit.edu	37	chr19	56691959	56691959	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgcatctctatccagggacGaggaggctggaccctcaata	10	8	11	12	1	2	0	1	0	1	0	4	4	3	3	2	4	1	2	2	4	3	2	rs149853638		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56691959G>A	uc002qmo.1	+	3	174	c.92G>A	c.(91-93)CGA>CAA	p.R31Q	GALP_uc010eti.2_Intron	NM_033106	NP_149097	Q9UBC7	GALP_HUMAN	galanin-like peptide isoform 1 precursor	31					neuropeptide signaling pathway	extracellular region	hormone activity				0		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		ATCCAGGGACGAGGAGGCTGG	0.607													19	44					0	0	0	0	A	56691959	A	A	56691959	3	1	276	1	0	0	0	0	1	0	0	0	6261	1058	37	1	98	1	GALP	19	56691959	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	176867	56691959	2437024	1910	51799											
ZNF582	147948	broad.mit.edu	37	chr19	56896527	56896528	+	Missense_Mutation	DNP	CC	TT	TT																															atgctgctttggaaataattCcttggtatcatatctggact																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56896527_56896528CC>TT	uc002qmz.1	-	5	417_418	c.258_259GG>AA	c.(256-261)AAGGAA>AAAAAA	p.E87K	ZNF582_uc002qmy.2_Missense_Mutation_p.E118K	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		GGAAATAATTCCTTGGTATCAT	0.356													18	64					0	0	0	0	TT	56896528	TT	TT	56896527	3	4	276	1	0	0	0	0	1	0	0	0	18081	864	30	2	1298	2	ZNF582	19	56896527	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	204568	56896527	2232456	1911	51800											
ZNF583	147949	broad.mit.edu	37	chr19	56934474	56934475	+	Missense_Mutation	DNP	CC	TT	TT																															atcatcactcataaagaaatCcttccagaagttcaaaataa																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56934474_56934475CC>TT	uc010ygl.1	+	5	612_613	c.447_448CC>TT	c.(445-450)ATCCTT>ATTTTT	p.L150F	ZNF583_uc002qnc.2_Missense_Mutation_p.L150F|ZNF583_uc010ygm.1_Missense_Mutation_p.L150F	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		ATAAAGAAATCCTTCCAGAAGT	0.366													16	114					0	0	0	0	TT	56934475	TT	TT	56934474	3	4	276	1	0	0	0	0	1	0	0	0	18082	845	30	2	461	2	ZNF583	19	56934474	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	37947	56934474	2194509	1912	51801											
ZNF667	63934	broad.mit.edu	37	chr19	56953821	56953821	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggatggatgagatctgtctGaaagcttttctacaattact	12	14	9	6	0	3	2	0	2	3	1	3	5	3	4	0	2	3	1	0	2	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:56953821G>A	uc002qnd.2	-	5	705	c.543C>T	c.(541-543)TTC>TTT	p.F181F	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_Silent_p.F181F|ZNF667_uc010etm.2_Silent_p.F124F	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	181	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		AGATCTGTCTGAAAGCTTTTC	0.383													25	121					0	0	0	0	A	56953821	A	A	56953821	2	1	276	1	0	0	0	0	0	0	0	1	18141	1281	45	2		2	ZNF667	19	56953821	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	19347	56953821	2175162	1913	51802											
ZNF835	90485	broad.mit.edu	37	chr19	57176536	57176536	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtttccttccaactctgcgcCctggagggcgacgctcaaga	7	9	11	14	3	2	1	1	0	1	1	4	3	4	2	3	2	2	2	3	2	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:57176536C>T	uc010ygo.1	-	2	97	c.97G>A	c.(97-99)GGC>AGC	p.G33S	ZNF835_uc010ygn.1_Missense_Mutation_p.G11S	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						AACTCTGCGCCCTGGAGGGCG	0.547													27	36					0	0	0	0	T	57176536	T	T	57176536	3	4	276	1	0	0	0	0	1	0	0	0	18253	623	22	4	1584	4	ZNF835	19	57176536	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	222715	57176536	1952447	1914	51803											
PEG3	5178	broad.mit.edu	37	chr19	57325361	57325361	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtcttcaattcccacaccGtcaggctcgtcggcatctcc	6	10	9	16	3	4	0	2	0	2	0	8	0	5	0	3	3	0	2	3	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:57325361G>T	uc002qnu.2	-	7	4800	c.4449C>A	c.(4447-4449)GAC>GAA	p.D1483E	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.D1454E|PEG3_uc002qnv.2_Missense_Mutation_p.D1483E|PEG3_uc002qnw.2_Missense_Mutation_p.D1359E|PEG3_uc002qnx.2_Missense_Mutation_p.D1357E|PEG3_uc010etr.2_Missense_Mutation_p.D1483E	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1483	Glu-rich.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCCCACACCGTCAGGCTCGT	0.493													63	154					2.3441e-25	2.44133e-25	1	0	T	57325361	T	T	57325361	3	4	276	1	0	0	0	0	1	0	0	0	11774	1136	40	3	321	3	PEG3	19	57325361	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	148825	57325361	1803622	1915	51804			2	78		5	5	2251	N	G_C	2.087142e-05
PEG3	5178	broad.mit.edu	37	chr19	57325830	57325830	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	attcatagaatggtatagctCctttgaggggctcagtaaga	12	12	11	6	0	2	3	2	1	0	2	3	3	3	3	1	3	1	4	1	3	5	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:57325830C>T	uc002qnu.2	-	7	4331	c.3980G>A	c.(3979-3981)GGA>GAA	p.G1327E	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G1298E|PEG3_uc002qnv.2_Missense_Mutation_p.G1327E|PEG3_uc002qnw.2_Missense_Mutation_p.G1203E|PEG3_uc002qnx.2_Missense_Mutation_p.G1201E|PEG3_uc010etr.2_Missense_Mutation_p.G1327E	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1327					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGGTATAGCTCCTTTGAGGGG	0.428													18	69					0	0	0	0	T	57325830	T	T	57325830	3	4	276	1	0	0	0	0	1	0	0	0	11774	855	30	2	790	2	PEG3	19	57325830	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	469	57325830	1803153	1916	51805			2	78		5	5	2251	N	G_C	2.087142e-05
PEG3	5178	broad.mit.edu	37	chr19	57326902	57326902	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccccacactcctgacattCatagagcatccctcgagggc	9	8	7	17	1	1	2	1	1	0	1	5	3	4	2	4	1	1	1	4	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:57326902C>T	uc002qnu.2	-	7	3259	c.2908G>A	c.(2908-2910)GAA>AAA	p.E970K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E941K|PEG3_uc002qnv.2_Missense_Mutation_p.E970K|PEG3_uc002qnw.2_Missense_Mutation_p.E846K|PEG3_uc002qnx.2_Missense_Mutation_p.E844K|PEG3_uc010etr.2_Missense_Mutation_p.E970K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	970	C2H2-type 5.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCCTGACATTCATAGAGCATC	0.458													54	150					0	0	0	0	T	57326902	T	T	57326902	3	4	276	1	0	0	0	0	1	0	0	0	11774	835	29	2	1862	2	PEG3	19	57326902	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1072	57326902	1802081	1917	51806			2	78		5	5	2251	N	G_C	2.087142e-05
PEG3	5178	broad.mit.edu	37	chr19	57327572	57327572	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaatggtgaacgccttttcGtcctcatcactttcaagagg	9	13	8	11	2	3	2	3	1	0	1	5	2	4	2	2	2	1	0	2	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:57327572G>A	uc002qnu.2	-	7	2589	c.2238C>T	c.(2236-2238)GAC>GAT	p.D746D	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.D717D|PEG3_uc002qnv.2_Silent_p.D746D|PEG3_uc002qnw.2_Silent_p.D622D|PEG3_uc002qnx.2_Silent_p.D620D|PEG3_uc010etr.2_Silent_p.D746D	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	746					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACGCCTTTTCGTCCTCATCAC	0.408													74	162					0	0	0	0	A	57327572	A	A	57327572	2	1	276	1	0	0	0	0	0	0	0	1	11774	1136	40	1		1	PEG3	19	57327572	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	670	57327572	1801411	1918	51807			2	78		5	5	2251	N	G_C	2.087142e-05
PEG3	5178	broad.mit.edu	37	chr19	57327611	57327611	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtcttgttatagtatgactCttctgagattcagtgaatgg	9	16	11	5	0	4	3	1	3	3	1	4	4	4	3	0	2	0	2	0	2	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:57327611C>G	uc002qnu.2	-	7	2550	c.2199G>C	c.(2197-2199)AAG>AAC	p.K733N	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.K704N|PEG3_uc002qnv.2_Missense_Mutation_p.K733N|PEG3_uc002qnw.2_Missense_Mutation_p.K609N|PEG3_uc002qnx.2_Missense_Mutation_p.K607N|PEG3_uc010etr.2_Missense_Mutation_p.K733N	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	733					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TAGTATGACTCTTCTGAGATT	0.413													63	93					0	0	0	0	G	57327611	G	G	57327611	3	3	276	1	0	0	0	0	1	0	0	0	11774	912	32	2	2571	2	PEG3	19	57327611	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	39	57327611	1801372	1919	51808			2	78		5	5	2251	N	G_C	2.087142e-05
USP29	57663	broad.mit.edu	37	chr19	57641804	57641804	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaagctgacctcagaatcCagtgattccctggttctacc	10	11	8	12	0	2	4	1	3	1	1	4	4	4	4	4	1	2	2	4	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:57641804C>T	uc002qny.2	+	4	2117	c.1761C>T	c.(1759-1761)TCC>TCT	p.S587S		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	587					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCTCAGAATCCAGTGATTCCC	0.488													13	114					0	0	0	0	T	57641804	T	T	57641804	2	4	276	1	0	0	0	0	0	0	0	1	17127	581	21	4		4	USP29	19	57641804	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	314193	57641804	1487179	1920	51809											
ZNF548	147694	broad.mit.edu	37	chr19	57910606	57910606	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagggaatgtgggaaattCtttatggacagctccacact	11	11	11	8	0	1	0	0	0	1	0	2	3	2	3	1	3	2	2	1	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:57910606C>T	uc002qom.2	+	3	1201	c.951C>T	c.(949-951)TTC>TTT	p.F317F	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Silent_p.F320F	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	317	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTGGGAAATTCTTTATGGACA	0.423													15	86					0	0	0	0	T	57910606	T	T	57910606	2	4	276	1	0	0	0	0	0	0	0	1	18047	912	32	2		2	ZNF548	19	57910606	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	268802	57910606	1218377	1921	51810											
ZNF17	7565	broad.mit.edu	37	chr19	57931851	57931851	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atactggagaacggccttatGgatgcaatgaatgtgggaaa	14	9	13	5	1	0	2	0	1	0	1	0	5	0	4	1	4	3	1	1	4	6	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:57931851G>A	uc002qoo.1	+	3	1222	c.991G>A	c.(991-993)GGA>AGA	p.G331R	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Missense_Mutation_p.G333R	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	331					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		ACGGCCTTATGGATGCAATGA	0.443													31	74					0	0	0	0	A	57931851	A	A	57931851	3	1	276	1	0	0	0	0	1	0	0	0	17810	1349	47	4	1001	4	ZNF17	19	57931851	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	21245	57931851	1197132	1922	51811											
ZNF530	348327	broad.mit.edu	37	chr19	58117311	58117311	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcaccagctccagaagcttGataatggagagaagctcttt	12	11	9	9	0	2	3	1	1	1	2	3	5	3	4	2	1	3	3	2	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:58117311G>A	uc002qpk.2	+	3	638	c.418G>A	c.(418-420)GAT>AAT	p.D140N	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CCAGAAGCTTGATAATGGAGA	0.473													20	96					0	0	0	0	A	58117311	A	A	58117311	3	1	276	1	0	0	0	0	1	0	0	0	18038	1290	45	2	428	2	ZNF530	19	58117311	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	185460	58117311	1011672	1923	51812											
ZNF551	90233	broad.mit.edu	37	chr19	58196721	58196721	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcctgtactgcgatgtgaTgctggagaactttgcacatg	8	13	12	8	1	0	2	0	1	0	1	1	4	1	2	1	1	5	4	1	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:58196721T>G	uc002qpw.3	+	2	348	c.125T>G	c.(124-126)ATG>AGG	p.M42R	ZNF551_uc002qpv.3_Intron|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	58	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGCGATGTGATGCTGGAGAAC	0.498													38	257					0	0	0	0	G	58196721	G	G	58196721	3	3	276	1	0	0	0	0	1	0	0	0	18050	1464	51	5	131	5	ZNF551	19	58196721	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	79410	58196721	932262	1924	51813											
ZNF418	147686	broad.mit.edu	37	chr19	58437850	58437850	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcccacattctctgcactCataaggtctttctgcagtgt	7	16	6	12	0	4	0	1	0	3	0	6	0	5	0	1	1	2	2	1	1	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:58437850C>T	uc002qqs.1	-	4	1991	c.1699G>A	c.(1699-1701)GAG>AAG	p.E567K	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.E482K	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	567					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TCTCTGCACTCATAAGGTCTT	0.438													24	71					0	0	0	0	T	58437850	T	T	58437850	3	4	276	1	0	0	0	0	1	0	0	0	17962	835	29	2	335	2	ZNF418	19	58437850	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	241129	58437850	691133	1925	51814											
C19orf18	147685	broad.mit.edu	37	chr19	58472858	58472858	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttcttcatctcctaataacgGtatcctgaggttcttataaa	11	16	5	9	1	4	1	1	1	3	0	6	1	5	1	2	2	1	2	2	2	6	8	rs35437132	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:58472858G>A	uc002qqv.2	-	5	537	c.433C>T	c.(433-435)CCG>TCG	p.P145S		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	145	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		CCTAATAACGGTATCCTGAGG	0.458													22	109					0	0	0	0	A	58472858	A	A	58472858	3	1	276	1	0	0	0	0	1	0	0	0	1919	1261	44	4	222	4	C19orf18	19	58472858	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	35008	58472858	656125	1926	51815											
ZNF606	80095	broad.mit.edu	37	chr19	58499607	58499607	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgaggacatgcctgctccActgaccacggctcttctcct	6	11	9	15	1	2	2	0	2	2	0	4	3	3	3	4	2	2	3	4	2	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:58499607A>C	uc002qqw.2	-	6	986	c.368T>G	c.(367-369)GTG>GGG	p.V123G	ZNF606_uc010yhp.1_Missense_Mutation_p.V33G	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	123	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TGCCTGCTCCACTGACCACGG	0.522													10	65					0	0	0	0	C	58499607	C	C	58499607	3	2	276	1	0	0	0	0	1	0	0	0	18099	159	6	5	2018	5	ZNF606	19	58499607	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	26749	58499607	629376	1927	51816											
ZNF135	7694	broad.mit.edu	37	chr19	58578350	58578350	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tggcagaggaatgggtttggGgaaaacataagtctgaaccc	13	8	14	6	0	1	2	0	1	1	1	1	4	1	4	1	5	2	2	1	5	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:58578350G>A	uc010yhq.1	+	5	630	c.534G>A	c.(532-534)GGG>GGA	p.G178G	ZNF135_uc002qre.2_Silent_p.G166G|ZNF135_uc002qrd.1_Silent_p.G124G|ZNF135_uc002qrf.2_Silent_p.G124G|ZNF135_uc002qrg.2_Silent_p.G136G|ZNF135_uc010yhr.1_5'UTR	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	178					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		ATGGGTTTGGGGAAAACATAA	0.542													19	27					0	0	0	0	A	58578350	A	A	58578350	2	1	276	1	0	0	0	0	0	0	0	1	17792	1219	43	4		4	ZNF135	19	58578350	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	78743	58578350	550633	1928	51817											
ZNF135	7694	broad.mit.edu	37	chr19	58578606	58578606	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgaatgcttaaaaggcttcCggaacagctcggcacttacc	12	8	9	12	3	0	0	0	0	0	0	2	2	1	1	2	3	4	4	2	3	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:58578606C>T	uc010yhq.1	+	5	886	c.790C>T	c.(790-792)CGG>TGG	p.R264W	ZNF135_uc002qre.2_Missense_Mutation_p.R252W|ZNF135_uc002qrd.1_Missense_Mutation_p.R210W|ZNF135_uc002qrf.2_Missense_Mutation_p.R210W|ZNF135_uc002qrg.2_Missense_Mutation_p.R222W|ZNF135_uc010yhr.1_Missense_Mutation_p.R73W	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	264					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		AAAAGGCTTCCGGAACAGCTC	0.502													21	145					0	0	0	0	T	58578606	T	T	58578606	3	4	276	1	0	0	0	0	1	0	0	0	17792	643	23	1	957	1	ZNF135	19	58578606	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	256	58578606	550377	1929	51818											
SLC27A5	10998	broad.mit.edu	37	chr19	59010014	59010014	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttgaagccctcacgcaccaaCcgggtcttcatcagtttgaa	10	10	8	13	2	4	2	3	2	1	0	4	2	4	2	3	1	2	2	3	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:59010014C>T	uc002qtc.2	-	10	2051	c.1941G>A	c.(1939-1941)CGG>CGA	p.R647R	SLC27A5_uc002qtb.2_RNA	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	647	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CACGCACCAACCGGGTCTTCA	0.592													11	26					0	0	0	0	T	59010014	T	T	59010014	2	4	276	1	0	0	0	0	0	0	0	1	14593	494	18	4		4	SLC27A5	19	59010014	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	431408	59010014	118969	1930	51819											
SLC27A5	10998	broad.mit.edu	37	chr19	59010864	59010864	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccctgcctcggaccggaaGgtgtccccgaggcggtcgcg	6	5	15	15	6	0	0	0	0	0	0	3	3	1	2	5	5	2	0	5	5	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr19:59010864G>A	uc002qtc.2	-	7	1772	c.1662C>T	c.(1660-1662)ACC>ACT	p.T554T	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	554	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CGGACCGGAAGGTGTCCCCGA	0.657													6	71					0	0	0	0	A	59010864	A	A	59010864	2	1	276	1	0	0	0	0	0	0	0	1	14593	987	35	4		4	SLC27A5	19	59010864	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	850	59010864	118119	1931	51820											
DEFB127	140850	broad.mit.edu	37	chr20	139628	139628	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaagactatgttacaataaTagaaaatttcccaagcctga	17	11	5	8	0	1	3	1	1	0	2	2	3	2	3	2	0	2	1	2	0	9	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:139628T>G	uc002wcy.1	+	2	263	c.263T>G	c.(262-264)ATA>AGA	p.I88R		NM_139074	NP_620713	Q9H1M4	DB127_HUMAN	defensin, beta 127 preproprotein	88					defense response to bacterium|innate immune response	extracellular region					0		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			GTTACAATAATAGAAAATTTC	0.363													21	31					0	0	0	0	G	139628	G	G	139628	3	3	276	1	0	0	0	0	1	0	0	0	4434	1406	49	5	269	5	DEFB127	20	139628	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08		139628	62885892	1932	51821											
PDYN	5173	broad.mit.edu	37	chr20	1961100	1961100	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagcttgggacgaatgcgccGcaagaagcccccatagcgtt	10	6	13	12	4	0	1	0	0	0	1	0	4	0	2	3	1	4	3	3	1	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:1961100G>A	uc010gaj.2	-	3	876	c.634C>T	c.(634-636)CGG>TGG	p.R212W	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.R212W|PDYN_uc010zpt.1_Missense_Mutation_p.R57W	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	212			R -> W (in SCA23; the mutant PDYN protein is produced, but processing to opioid peptides is dramatically affected, with increased levels of dynorphin A compared to dynorphin B; mutant dynorphin A is neurotoxic to cultured striatal neurons, suggesting a dominant-negative effect).		cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						CGAATGCGCCGCAAGAAGCCC	0.587													26	149					0	0	0	0	A	1961100	A	A	1961100	3	1	276	1	0	0	0	0	1	0	0	0	11753	1086	38	1	134	1	PDYN	20	1961100	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1821472	1961100	61064420	1933	51822											
CPXM1	56265	broad.mit.edu	37	chr20	2779447	2779448	+	Missense_Mutation	DNP	GG	AA	AA																															gggcccggcagtcaccagtgGggtggggcgagttagagtta																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:2779447_2779448GG>AA	uc002wgu.2	-	2	328_329	c.264_265CC>TT	c.(262-267)ACCCCA>ACTTCA	p.P89S	CPXM1_uc010gas.2_Missense_Mutation_p.P89S	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	89					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						GTCACCAGTGGGGTGGGGCGAG	0.574													48	117					0	0	0	0	AA	2779448	AA	AA	2779447	3	1	276	1	0	0	0	0	1	0	0	0	3852	1232	43	4	1991	4	CPXM1	20	2779447	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	818347	2779447	60246073	1934	51823											
SLC4A11	83959	broad.mit.edu	37	chr20	3214206	3214206	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgacgaaccgaacctcacagGaattctccccccagttctgt	10	9	7	15	2	3	1	1	1	2	0	4	4	3	2	5	1	2	1	5	1	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:3214206G>A	uc002wig.2	-	6	779	c.731C>T	c.(730-732)TCC>TTC	p.S244F	SLC4A11_uc010zqe.1_Missense_Mutation_p.S271F|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.S228F	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	244	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						AACCTCACAGGAATTCTCCCC	0.642													13	79					0	0	0	0	A	3214206	A	A	3214206	3	1	276	1	0	0	0	0	1	0	0	0	14716	1174	41	2	2000	2	SLC4A11	20	3214206	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	434759	3214206	59811314	1935	51824											
ADAM33	80332	broad.mit.edu	37	chr20	3655679	3655679	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggaagcatctcaccgtgtGgttgggggccagcaccactg	8	8	14	11	1	1	0	1	0	1	0	2	1	1	1	3	4	2	3	3	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:3655679G>A	uc002wit.2	-	4	415	c.328C>T	c.(328-330)CAC>TAC	p.H110Y	ADAM33_uc002wir.1_Missense_Mutation_p.H110Y|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Missense_Mutation_p.H110Y|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Missense_Mutation_p.H109Y|ADAM33_uc010zqg.1_Missense_Mutation_p.H109Y|ADAM33_uc010zqh.1_Missense_Mutation_p.H110Y	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	110	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						CTCACCGTGTGGTTGGGGGCC	0.617													17	101					0	0	0	0	A	3655679	A	A	3655679	3	1	276	1	0	0	0	0	1	0	0	0	250	1348	47	4	2189	4	ADAM33	20	3655679	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	441473	3655679	59369841	1936	51825											
SIGLEC1	6614	broad.mit.edu	37	chr20	3672822	3672822	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggccctggagtcccggaagGaggacaggacagcgtcctga	9	5	16	11	2	0	1	0	1	0	0	2	6	2	6	3	6	1	0	3	6	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:3672822G>A	uc002wja.2	-	16	4058	c.4058C>T	c.(4057-4059)TCC>TTC	p.S1353F	SIGLEC1_uc002wjb.1_5'UTR|SIGLEC1_uc002wiz.3_Missense_Mutation_p.S1353F	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1353	Ig-like C2-type 14.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GTCCCGGAAGGAGGACAGGAC	0.612													17	51					0	0	0	0	A	3672822	A	A	3672822	3	1	276	1	0	0	0	0	1	0	0	0	14370	1174	41	2	1095	2	SIGLEC1	20	3672822	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	17143	3672822	59352698	1937	51826											
SIGLEC1	6614	broad.mit.edu	37	chr20	3677377	3677377	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttagcctggaaccgaccatGggatgggacctggggaccca	9	7	14	11	1	0	0	0	0	0	0	0	5	0	4	5	5	2	0	5	5	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:3677377G>A	uc002wja.2	-	10	2539	c.2539C>T	c.(2539-2541)CAT>TAT	p.H847Y	SIGLEC1_uc002wiz.3_Missense_Mutation_p.H847Y	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	847	Ig-like C2-type 8.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						AACCGACCATGGGATGGGACC	0.622													27	79					0	0	0	0	A	3677377	A	A	3677377	3	1	276	1	0	0	0	0	1	0	0	0	14370	1348	47	4	2638	4	SIGLEC1	20	3677377	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4555	3677377	59348143	1938	51827											
SIGLEC1	6614	broad.mit.edu	37	chr20	3679949	3679949	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcagtgctggaggccgcgggGagcaggaggctgctgccggg	5	5	21	10	3	1	0	1	0	0	0	1	3	1	3	2	7	4	4	2	7	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:3679949G>A	uc002wja.2	-	7	1686	c.1686C>T	c.(1684-1686)CTC>CTT	p.L562L	SIGLEC1_uc002wiz.3_Silent_p.L562L	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	562	Ig-like C2-type 5.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						AGGCCGCGGGGAGCAGGAGGC	0.672													3	23					0	0	0	0	A	3679949	A	A	3679949	2	1	276	1	0	0	0	0	0	0	0	1	14370	1161	41	2		2	SIGLEC1	20	3679949	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2572	3679949	59345571	1939	51828											
SIGLEC1	6614	broad.mit.edu	37	chr20	3684712	3684712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttcctccccgaggggctgaGgaggatcttcacacccttgg	6	9	13	13	1	2	1	1	1	1	0	4	4	4	3	4	5	0	2	4	5	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:3684712G>A	uc002wja.2	-	4	733	c.733C>T	c.(733-735)CTC>TTC	p.L245F	SIGLEC1_uc002wiz.3_Missense_Mutation_p.L245F|SIGLEC1_uc002wjc.2_Missense_Mutation_p.L156F	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	245	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GAGGGGCTGAGGAGGATCTTC	0.577													18	65					0	0	0	0	A	3684712	A	A	3684712	3	1	276	1	0	0	0	0	1	0	0	0	14370	1000	35	4	4468	4	SIGLEC1	20	3684712	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4763	3684712	59340808	1940	51829											
PROKR2	128674	broad.mit.edu	37	chr20	5294626	5294627	+	Missense_Mutation	DNP	GG	AA	AA																															acggtgcgcaggtagttgacGgaggcacagagcacgtggcc																								rs144778137	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:5294626_5294627GG>AA	uc010zqw.1	-	1	389_390	c.389_390CC>TT	c.(388-390)TCC>TTT	p.S130F	PROKR2_uc010zqx.1_Missense_Mutation_p.S130F|PROKR2_uc010zqy.1_Missense_Mutation_p.S130F|uc002wly.1_5'Flank	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	130	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GGTAGTTGACGGAGGCACAGAG	0.609										HNSCC(71;0.22)			12	55					0	0	0	0	AA	5294627	AA	AA	5294626	3	1	276	1	0	0	0	0	1	0	0	0	12615	1103	39	1	771	1	PROKR2	20	5294626	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	1609914	5294626	57730894	1941	51830											
GPCPD1	56261	broad.mit.edu	37	chr20	5550825	5550825	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaacaacaggtaagatcatGatataccacgggcacaaagt	18	6	8	9	1	1	2	1	1	0	1	1	2	1	2	1	2	3	2	1	2	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:5550825G>A	uc002wme.3	-	12	1330	c.1117C>T	c.(1117-1119)CAT>TAT	p.H373Y	GPCPD1_uc002wmd.3_Missense_Mutation_p.H192Y	NM_019593	NP_062539	Q9NPB8	GPCP1_HUMAN	hypothetical protein LOC56261	373	GDPD.				glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0						GTAAGATCATGATATACCACG	0.353													10	96					0	0	0	0	A	5550825	A	A	5550825	3	1	276	1	0	0	0	0	1	0	0	0	6641	1290	45	2	937	2	GPCPD1	20	5550825	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	256199	5550825	57474695	1942	51831											
CHGB	1114	broad.mit.edu	37	chr20	5903905	5903905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaagtgaagaatacagggCtccaagacctcagagtgagg	15	5	14	7	0	1	5	1	2	0	3	2	6	2	6	2	3	1	1	2	3	5	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:5903905C>T	uc002wmg.2	+	4	1421	c.1115C>T	c.(1114-1116)GCT>GTT	p.A372V	CHGB_uc010zqz.1_Missense_Mutation_p.A55V	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	372						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GAATACAGGGCTCCAAGACCT	0.507													51	80					0	0	0	0	T	5903905	T	T	5903905	3	4	276	1	0	0	0	0	1	0	0	0	3354	797	28	4	1129	4	CHGB	20	5903905	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	353080	5903905	57121615	1943	51832											
JAG1	182	broad.mit.edu	37	chr20	10630991	10630991	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cccgtgggaacagttattagGagaacagtcatcaatgtctg	12	10	11	8	1	3	1	2	0	1	1	3	3	3	2	1	2	2	1	1	2	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:10630991G>A	uc002wnw.2	-	9	1654	c.1138C>T	c.(1138-1140)CCT>TCT	p.P380S	JAG1_uc010gcd.1_5'UTR	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	380	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						CAGTTATTAGGAGAACAGTCA	0.458									Alagille_Syndrome				21	27					0	0	0	0	A	10630991	A	A	10630991	3	1	276	1	0	0	0	0	1	0	0	0	7973	1174	41	2	2590	2	JAG1	20	10630991	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4727086	10630991	52394529	1944	51833											
BFSP1	631	broad.mit.edu	37	chr20	17475391	17475391	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgaccttcctgtatagtttCccaaagcctttgcttatctg	7	17	6	11	0	1	1	0	1	1	0	3	1	3	1	4	0	2	3	4	0	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:17475391C>T	uc002wpo.2	-	8	1365	c.1326G>A	c.(1324-1326)GGG>GGA	p.G442G	BFSP1_uc002wpp.2_Silent_p.G317G|BFSP1_uc010zrn.1_Silent_p.G303G|BFSP1_uc010zro.1_Silent_p.G303G	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	442	Tail.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						TGTATAGTTTCCCAAAGCCTT	0.507													34	202					0	0	0	0	T	17475391	T	T	17475391	2	4	276	1	0	0	0	0	0	0	0	1	1418	842	30	2		2	BFSP1	20	17475391	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	6844400	17475391	45550129	1945	51834											
SLC24A3	57419	broad.mit.edu	37	chr20	19665797	19665797	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacggggaatctgaggtggcCatcaaaatcccaattaagca	15	7	10	9	1	2	1	1	1	1	0	3	2	3	2	2	4	2	1	2	4	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:19665797C>T	uc002wrl.2	+	12	1313	c.1116C>T	c.(1114-1116)GCC>GCT	p.A372A		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	372	Cytoplasmic (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						CTGAGGTGGCCATCAAAATCC	0.537													14	115					0	0	0	0	T	19665797	T	T	19665797	2	4	276	1	0	0	0	0	0	0	0	1	14531	581	21	4		4	SLC24A3	20	19665797	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2190406	19665797	43359723	1946	51835											
C20orf26	26074	broad.mit.edu	37	chr20	20208964	20208964	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attactgtcaatgccaagatCattgtggttggtgcatccag	10	13	10	8	0	2	1	2	0	0	1	3	1	3	1	2	2	3	2	2	2	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:20208964C>T	uc002wru.2	+	18	2080	c.2004C>T	c.(2002-2004)ATC>ATT	p.I668I	C20orf26_uc010zse.1_Silent_p.I648I|C20orf26_uc002wrw.2_RNA|C20orf26_uc002wrv.2_Silent_p.I24I	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	668										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		ATGCCAAGATCATTGTGGTTG	0.333													93	110					0	0	0	0	T	20208964	T	T	20208964	2	4	276	1	0	0	0	0	0	0	0	1	2116	816	29	2		2	C20orf26	20	20208964	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	543167	20208964	42816556	1947	51836											
NINL	22981	broad.mit.edu	37	chr20	25481637	25481637	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtggtgtggcagccgctctCctctgggacctgcatgtcag	4	10	15	12	1	3	0	1	0	2	0	4	1	3	1	3	4	2	3	3	4	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:25481637C>T	uc002wux.1	-	8	945	c.871G>A	c.(871-873)GAG>AAG	p.E291K	NINL_uc010gdn.1_Missense_Mutation_p.E291K|NINL_uc010gdo.1_Intron|NINL_uc010ztf.1_Missense_Mutation_p.E307K	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	291					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CAGCCGCTCTCCTCTGGGACC	0.612													11	20					0	0	0	0	T	25481637	T	T	25481637	3	4	276	1	0	0	0	0	1	0	0	0	10474	864	30	2	3345	2	NINL	20	25481637	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5272673	25481637	37543883	1948	51837											
NINL	22981	broad.mit.edu	37	chr20	25498400	25498400	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctcttacctgattccaaaGaactactgtcttcatctgag	10	14	5	12	0	4	3	1	2	3	1	6	3	6	3	3	0	3	0	3	0	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:25498400G>A	uc002wux.1	-	3	340	c.266C>T	c.(265-267)TCT>TTT	p.S89F	NINL_uc010gdn.1_Missense_Mutation_p.S89F|NINL_uc010gdo.1_5'UTR|NINL_uc010ztf.1_Missense_Mutation_p.S105F	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	89					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TGATTCCAAAGAACTACTGTC	0.378													18	40					0	0	0	0	A	25498400	A	A	25498400	3	1	276	1	0	0	0	0	1	0	0	0	10474	942	33	2	3970	2	NINL	20	25498400	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	16763	25498400	37527120	1949	51838											
ZNF337	26152	broad.mit.edu	37	chr20	25656044	25656044	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacactccttgcatacaaaaGgctgcttgccagaatgtgca	12	9	8	12	0	0	1	0	0	0	1	1	1	1	1	2	1	5	4	2	1	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:25656044G>A	uc002wva.2	-	4	2402	c.1880C>T	c.(1879-1881)CCT>CTT	p.P627L	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Missense_Mutation_p.P595L|ZNF337_uc002wvb.2_Missense_Mutation_p.P627L|ZNF337_uc002wvc.2_Missense_Mutation_p.P627L	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	627					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCATACAAAAGGCTGCTTGCC	0.498													34	117					0	0	0	0	A	25656044	A	A	25656044	3	1	276	1	0	0	0	0	1	0	0	0	17920	1000	35	4	379	4	ZNF337	20	25656044	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	157644	25656044	37369476	1950	51839											
DEFB115	245929	broad.mit.edu	37	chr20	29847382	29847382	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctgtgtccctaaagaaaagGataaactatcacacattcac	16	9	6	10	0	2	1	2	0	0	1	3	2	3	2	1	1	1	1	1	1	7	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:29847382G>A	uc002wvp.1	+	2	214	c.214G>A	c.(214-216)GAT>AAT	p.D72N		NM_001037730	NP_001032819	Q30KQ5	DB115_HUMAN	beta-defensin 115 precursor	72					defense response to bacterium	extracellular region				ovary(1)	1			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			TAAAGAAAAGGATAAACTATC	0.348													7	61					0	0	0	0	A	29847382	A	A	29847382	3	1	276	1	0	0	0	0	1	0	0	0	4425	1174	41	2	220	2	DEFB115	20	29847382	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4191338	29847382	33178138	1951	51840											
DEFB118	117285	broad.mit.edu	37	chr20	29960871	29960871	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attttaacagtaaggttcacGacagactactttgaagtaag	15	12	8	6	1	1	2	1	1	0	1	1	3	1	2	0	1	2	3	0	1	5	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:29960871G>A	uc002wvr.2	+	2	296	c.270G>A	c.(268-270)ACG>ACA	p.T90T		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	90					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TAAGGTTCACGACAGACTACT	0.453													15	108					0	0	0	0	A	29960871	A	A	29960871	2	1	276	1	0	0	0	0	0	0	0	1	4427	1045	37	1		1	DEFB118	20	29960871	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	113489	29960871	33064649	1952	51841											
DUSP15	128853	broad.mit.edu	37	chr20	30436629	30436629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtccgccatgatgagctgctCcttggggtgctgtgtggggc	3	11	17	10	1	0	2	0	2	0	0	2	2	2	2	3	4	3	3	3	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:30436629C>T	uc002wwu.1	-	9	783	c.706G>A	c.(706-708)GAG>AAG	p.E236K				Q9H1R2	DUS15_HUMAN	RecName: Full=Dual specificity protein phosphatase 15;          EC=3.1.3.48;          EC=3.1.3.16; AltName: Full=Vaccinia virus VH1-related dual-specific protein phosphatase Y; AltName: Full=VH1-related member Y;	236						cytoplasm|plasma membrane	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			ATGAGCTGCTCCTTGGGGTGC	0.607													6	23					0	0	0	0	T	30436629	T	T	30436629	3	4	276	1	0	0	0	0	1	0	0	0	4837	870	30	2		2	DUSP15	20	30436629	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	475758	30436629	32588891	1953	51842											
TTLL9	164395	broad.mit.edu	37	chr20	30486286	30486286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtcttgcagagagcagagaGcatcgatccggttcaagacc	11	8	12	10	2	2	3	1	0	1	3	4	6	3	3	2	1	3	4	2	1	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:30486286G>A	uc010gdx.1	+	4	377	c.124G>A	c.(124-126)GCA>ACA	p.A42T	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_RNA|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Missense_Mutation_p.S51N|TTLL9_uc010ztp.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	42	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGAGCAGAGAGCATCGATCCG	0.517													11	88					0	0	0	0	A	30486286	A	A	30486286	3	1	276	1	0	0	0	0	1	0	0	0	16802	971	34	4	134	4	TTLL9	20	30486286	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	49657	30486286	32539234	1954	51843											
TTLL9	164395	broad.mit.edu	37	chr20	30522680	30522680	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatgacatcctcatcgaccaGgacctcaagccgtaagtggg	11	8	10	12	2	2	1	2	1	0	0	4	3	3	2	4	2	1	1	4	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:30522680G>A	uc010gdx.1	+	12	1246	c.993G>A	c.(991-993)CAG>CAA	p.Q331Q	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_Intron|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Silent_p.Q233Q|TTLL9_uc010ztp.1_RNA|TTLL9_uc010ztq.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	331	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TCATCGACCAGGACCTCAAGC	0.398													29	79					0	0	0	0	A	30522680	A	A	30522680	2	1	276	1	0	0	0	0	0	0	0	1	16802	991	35	4		4	TTLL9	20	30522680	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	36394	30522680	32502840	1955	51844											
TM9SF4	9777	broad.mit.edu	37	chr20	30730848	30730848	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaggacatggaagaggacCaggagcacacgtaccgtgtc	12	4	16	9	2	0	1	0	0	0	1	1	6	0	6	2	5	2	2	2	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:30730848C>T	uc002wxj.2	+	6	827	c.592C>T	c.(592-594)CAG>TAG	p.Q198*	TM9SF4_uc010ztr.1_Nonsense_Mutation_p.Q124*|TM9SF4_uc010zts.1_Nonsense_Mutation_p.Q105*|TM9SF4_uc002wxk.2_Nonsense_Mutation_p.Q181*|TM9SF4_uc010gdz.2_Nonsense_Mutation_p.Q105*	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	198						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGAAGAGGACCAGGAGCACAC	0.562													50	54					0	0	0	0	T	30730848	T	T	30730848	4	4	276	1	0	0	0	0	0	1	0	0	16046	595	21	4	614	4	TM9SF4	20	30730848	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	208168	30730848	32294672	1956	51845											
PLAGL2	5326	broad.mit.edu	37	chr20	30784317	30784317	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caggccagacgtgaagacagGaggcaaggagtgcagaggcc	13	2	17	9	1	0	4	0	1	0	3	0	6	0	6	2	5	1	2	2	5	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:30784317G>A	uc002wxn.2	-	3	1646	c.1429C>T	c.(1429-1431)CCT>TCT	p.P477S		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	477						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GTGAAGACAGGAGGCAAGGAG	0.582													25	55					0	0	0	0	A	30784317	A	A	30784317	3	1	276	1	0	0	0	0	1	0	0	0	12075	1174	41	2	65	2	PLAGL2	20	30784317	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	53469	30784317	32241203	1957	51846											
PLAGL2	5326	broad.mit.edu	37	chr20	30785254	30785254	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggcctgggtactctcaaaGgtctgcaggcacaccttgca	9	8	12	12	0	2	0	1	0	2	0	3	0	2	0	2	4	3	4	2	4	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:30785254G>A	uc002wxn.2	-	3	709	c.492C>T	c.(490-492)ACC>ACT	p.T164T		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	164	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TACTCTCAAAGGTCTGCAGGC	0.617													6	31					0	0	0	0	A	30785254	A	A	30785254	2	1	276	1	0	0	0	0	0	0	0	1	12075	987	35	4		4	PLAGL2	20	30785254	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	937	30785254	32240266	1958	51847											
MYH7B	57644	broad.mit.edu	37	chr20	33568428	33568428	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcaacccctacaaatggctCccagtctatacggcctccgt	10	9	6	16	2	2	0	1	0	1	0	4	0	4	0	5	2	3	1	5	2	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:33568428C>T	uc010gfa.1	+	5	511	c.390C>T	c.(388-390)CTC>CTT	p.L130L	MYH7B_uc002xbi.1_Silent_p.L172L			A7E2Y1	MYH7B_HUMAN	RecName: Full=Myosin-7B; AltName: Full=Myosin heavy chain 7B, cardiac muscle beta isoform; AltName: Full=Myosin cardiac muscle beta chain; AltName: Full=Antigen MLAA-21; AltName: Full=Slow A MYH14;	130	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			ACAAATGGCTCCCAGTCTATA	0.468													27	242					0	0	0	0	T	33568428	T	T	33568428	2	4	276	1	0	0	0	0	0	0	0	1	10093	842	30	2		2	MYH7B	20	33568428	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2783174	33568428	29457092	1959	51848											
FAM83C	128876	broad.mit.edu	37	chr20	33875587	33875587	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggcttgggacatcaggcCtgaaggctagggccacaggg	8	6	18	9	0	1	1	1	1	0	0	1	2	1	2	2	7	0	2	2	7	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:33875587C>T	uc010zux.1	-	4	1113	c.995G>A	c.(994-996)AGG>AAG	p.R332K	EIF6_uc002xbx.1_5'Flank|EIF6_uc002xbz.1_5'Flank|EIF6_uc002xby.1_5'Flank|FAM83C_uc002xcb.1_Intron	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	332										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GACATCAGGCCTGAAGGCTAG	0.652													6	9					0	0	0	0	T	33875587	T	T	33875587	3	4	276	1	0	0	0	0	1	0	0	0	5667	681	24	4	1252	4	FAM83C	20	33875587	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	307159	33875587	29149933	1960	51849											
PHF20	51230	broad.mit.edu	37	chr20	34451277	34451277	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtccacaagaaaacttgaggGaacccaaaagaaaacgaggc	19	3	10	9	1	0	3	0	1	0	2	1	5	1	4	2	2	3	0	2	2	8	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:34451277G>A	uc002xek.1	+	6	874	c.763G>A	c.(763-765)GAA>AAA	p.E255K	PHF20_uc002xei.1_Missense_Mutation_p.E255K|PHF20_uc010gfo.1_Missense_Mutation_p.E255K|PHF20_uc002xej.1_Missense_Mutation_p.E139K|PHF20_uc002xel.1_Missense_Mutation_p.E117K	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					AAACTTGAGGGAACCCAAAAG	0.448													31	180					0	0	0	0	A	34451277	A	A	34451277	3	1	276	1	0	0	0	0	1	0	0	0	11886	1175	41	2	781	2	PHF20	20	34451277	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	575690	34451277	28574243	1961	51850											
PHF20	51230	broad.mit.edu	37	chr20	34487531	34487531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cttcagacaagcccagccagGagaccctgaccaggaagcgg	12	3	12	14	1	1	3	1	1	0	2	1	5	1	4	4	3	3	0	4	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:34487531G>A	uc002xek.1	+	10	1633	c.1522G>A	c.(1522-1524)GAG>AAG	p.E508K	PHF20_uc002xei.1_Missense_Mutation_p.E508K|PHF20_uc010gfo.1_Missense_Mutation_p.E508K|PHF20_uc002xej.1_Missense_Mutation_p.E392K	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					GCCCAGCCAGGAGACCCTGAC	0.537													26	62					0	0	0	0	A	34487531	A	A	34487531	3	1	276	1	0	0	0	0	1	0	0	0	11886	1175	41	2	1556	2	PHF20	20	34487531	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	36254	34487531	28537989	1962	51851											
RBL1	5933	broad.mit.edu	37	chr20	35632247	35632248	+	Missense_Mutation	DNP	GG	AA	AA																															gttgtttaatatgtggaaaaGgagagagtggtggagcatcc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:35632247_35632248GG>AA	uc002xgi.2	-	21	2972_2973	c.2893_2894CC>TT	c.(2893-2895)CCT>TTT	p.P965F	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.P965F	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	965					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				ATGTGGAAAAGGAGAGAGTGGT	0.396													13	51					0	0	0	0	AA	35632248	AA	AA	35632247	3	1	276	1	0	0	0	0	1	0	0	0	13174	1000	35	4	329	4	RBL1	20	35632247	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	1144716	35632247	27393273	1963	51852											
C20orf132	140699	broad.mit.edu	37	chr20	35776293	35776293	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagccactaggtgtccaagtCtttggaatcgcagtggaagc	10	9	13	9	1	1	0	0	0	1	0	3	3	2	2	2	3	2	1	2	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:35776293C>T	uc010zvu.1	-	12	1215	c.1124G>A	c.(1123-1125)AGA>AAA	p.R375K	C20orf132_uc002xgk.2_Missense_Mutation_p.R48K|C20orf132_uc002xgm.2_Missense_Mutation_p.R375K|C20orf132_uc002xgn.2_Missense_Mutation_p.R340K	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	250											0		Myeloproliferative disorder(115;0.00878)				GTGTCCAAGTCTTTGGAATCG	0.478													12	33					0	0	0	0	T	35776293	T	T	35776293	3	4	276	1	0	0	0	0	1	0	0	0	2096	913	32	2	2106	2	C20orf132	20	35776293	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	144046	35776293	27249227	1964	51853											
SRC	6714	broad.mit.edu	37	chr20	36012652	36012652	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcgctggcgggggcgctttCcccgcctcgcagacccccag	3	5	15	18	5	0	1	0	0	0	1	2	1	1	1	5	4	0	3	5	4	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:36012652C>T	uc002xgx.2	+	4	545	c.96C>T	c.(94-96)TTC>TTT	p.F32F	SRC_uc002xgy.2_Silent_p.F32F	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	32					axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	GGGGCGCTTTCCCCGCCTCGC	0.751													11	25					0	0	0	0	T	36012652	T	T	36012652	2	4	276	1	0	0	0	0	0	0	0	1	15200	854	30	2		2	SRC	20	36012652	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	236359	36012652	27012868	1965	51854											
KIAA0406	9675	broad.mit.edu	37	chr20	36641079	36641079	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgaggaagagatgtggcaagGgaatgcaggctttctgacaa	13	7	15	6	1	1	2	0	1	1	1	1	6	1	4	0	4	1	3	0	4	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:36641079G>A	uc002xhl.2	-	3	1349	c.1140C>T	c.(1138-1140)TCC>TCT	p.S380S	KIAA0406_uc002xhm.2_Silent_p.S380S	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	380							binding				0		Myeloproliferative disorder(115;0.00874)				ATGTGGCAAGGGAATGCAGGC	0.463													43	249					0	0	0	0	A	36641079	A	A	36641079	2	1	276	1	0	0	0	0	0	0	0	1	8212	1219	43	4		4	KIAA0406	20	36641079	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	628427	36641079	26384441	1966	51855											
KIAA0406	9675	broad.mit.edu	37	chr20	36641942	36641942	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgaaaagagttcctggaGaagctcctgttctttcacac	10	13	8	10	0	3	3	1	1	2	2	5	4	5	3	2	1	1	3	2	1	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:36641942G>A	uc002xhl.2	-	3	486	c.277C>T	c.(277-279)CTC>TTC	p.L93F	KIAA0406_uc002xhm.2_Missense_Mutation_p.L93F	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	93							binding				0		Myeloproliferative disorder(115;0.00874)				AGTTCCTGGAGAAGCTCCTGT	0.493													50	125					0	0	0	0	A	36641942	A	A	36641942	3	1	276	1	0	0	0	0	1	0	0	0	8212	942	33	2	3020	2	KIAA0406	20	36641942	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	863	36641942	26383578	1967	51856											
KIAA1755	85449	broad.mit.edu	37	chr20	36855595	36855595	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcagctggagagccgcctcCttctcccccaggaagagaat	9	7	11	14	1	1	2	0	0	1	2	3	5	2	3	5	2	3	2	5	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:36855595C>T	uc002xhy.1	-	7	2285	c.2013G>A	c.(2011-2013)AAG>AAA	p.K671K	KIAA1755_uc002xhz.1_Silent_p.K671K	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	671										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GAGCCGCCTCCTTCTCCCCCA	0.602													10	63					0	0	0	0	T	36855595	T	T	36855595	2	4	276	1	0	0	0	0	0	0	0	1	8296	680	24	4		4	KIAA1755	20	36855595	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	213653	36855595	26169925	1968	51857											
RALGAPB	57148	broad.mit.edu	37	chr20	37154598	37154598	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttatgataaaccaataactTttctgtccctgaagttgaga	13	14	6	8	0	1	3	0	3	1	1	2	4	2	3	2	0	2	1	2	0	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:37154598T>C	uc002xiw.2	+	13	2220	c.1963T>C	c.(1963-1965)TTT>CTT	p.F655L	RALGAPB_uc002xix.2_Missense_Mutation_p.F655L|RALGAPB_uc002xiy.1_Missense_Mutation_p.F655L|RALGAPB_uc002xiz.2_Missense_Mutation_p.F433L|RALGAPB_uc002xja.1_Missense_Mutation_p.F382L	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	655					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						ACCAATAACTTTTCTGTCCCT	0.363													40	101					0	0	0	0	C	37154598	C	C	37154598	3	2	276	1	0	0	0	0	1	0	0	0	13080	1841	64	5	2009	5	RALGAPB	20	37154598	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	299003	37154598	25870922	1969	51858											
PLCG1	5335	broad.mit.edu	37	chr20	39793697	39793697	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgtggagatctctgccgacGggctcccctcacccaaccag	7	6	10	18	3	2	1	1	0	1	1	4	3	3	1	6	2	2	1	6	2	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:39793697G>A	uc002xjp.1	+	13	1463	c.1342G>A	c.(1342-1344)GGG>AGG	p.G448R	PLCG1_uc002xjo.1_Missense_Mutation_p.G448R|PLCG1_uc010zwe.1_Missense_Mutation_p.G74R|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	448	PI-PLC X-box.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				CTCTGCCGACGGGCTCCCCTC	0.597													13	31					0	0	0	0	A	39793697	A	A	39793697	3	1	276	1	0	0	0	0	1	0	0	0	12090	1116	39	1	1392	1	PLCG1	20	39793697	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2639099	39793697	23231823	1970	51859											
TOMM34	10953	broad.mit.edu	37	chr20	43572214	43572214	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttcaggaccaaatagcaGagtgctctgaagggaaagac	14	7	12	8	0	2	3	1	1	1	2	2	5	2	5	1	2	3	3	1	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:43572214G>A	uc002xmy.2	-	6	845	c.705C>T	c.(703-705)CTC>CTT	p.L235L	PABPC1L_uc002xmx.2_Intron|TOMM34_uc002xmz.2_RNA	NM_006809	NP_006800	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	235	TPR 5.				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding				0		Myeloproliferative disorder(115;0.0122)				CCAAATAGCAGAGTGCTCTGA	0.463													33	113					0	0	0	0	A	43572214	A	A	43572214	2	1	276	1	0	0	0	0	0	0	0	1	16423	929	33	2		2	TOMM34	20	43572214	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3778517	43572214	19453306	1971	51860											
DNTTIP1	116092	broad.mit.edu	37	chr20	44430653	44430653	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcagaggaaaggacggcctCctggacacatcctgtcaagc	11	5	13	12	1	1	1	1	0	0	1	3	4	3	4	3	5	1	1	3	5	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:44430653C>T	uc002xpk.2	+	7	582	c.514C>T	c.(514-516)CCT>TCT	p.P172S		NM_052951	NP_443183	Q9H147	TDIF1_HUMAN	terminal deoxynucleotidyltransferase interacting	172						nucleus				ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.0122)				AGGACGGCCTCCTGGACACAT	0.602													34	114					0	0	0	0	T	44430653	T	T	44430653	3	4	276	1	0	0	0	0	1	0	0	0	4703	855	30	2	540	2	DNTTIP1	20	44430653	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	858439	44430653	18594867	1972	51861											
PCIF1	63935	broad.mit.edu	37	chr20	44574858	44574858	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgatgttcggcgtgggccTctacgaggggactggcctgc	5	9	17	10	3	1	1	0	1	1	0	2	4	1	2	2	5	2	1	2	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:44574858T>C	uc002xqs.2	+	14	1762	c.1448T>C	c.(1447-1449)CTC>CCC	p.L483P	PCIF1_uc002xqt.2_Missense_Mutation_p.L63P|PCIF1_uc002xqu.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	483						nucleus				skin(1)	1						GGCGTGGGCCTCTACGAGGGG	0.667													12	93					0	0	0	0	C	44574858	C	C	44574858	3	2	276	1	0	0	0	0	1	0	0	0	11634	1551	54	5	1494	5	PCIF1	20	44574858	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	144205	44574858	18450662	1973	51862											
CD40	958	broad.mit.edu	37	chr20	44750928	44750928	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaacggaatgccttccttgcGgtgaaagcgaattcctagac	12	9	10	10	3	0	2	0	1	0	1	2	4	2	3	3	2	4	0	3	2	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:44750928G>A	uc002xrg.1	+	3	264	c.187G>A	c.(187-189)GGT>AGT	p.G63S	CD40_uc002xrf.1_Missense_Mutation_p.G63S|CD40_uc002xrh.1_Missense_Mutation_p.G63S|CD40_uc002xri.1_Missense_Mutation_p.G63S|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	63	TNFR-Cys 2.|Extracellular (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	CCTTCCTTGCGGTGAAAGCGA	0.537									Immune_Deficiency_with_Hyper-IgM				10	106					0	0	0	0	A	44750928	A	A	44750928	3	1	276	1	0	0	0	0	1	0	0	0	3030	1116	39	1	197	1	CD40	20	44750928	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	176070	44750928	18274592	1974	51863											
SLC2A10	81031	broad.mit.edu	37	chr20	45354665	45354665	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gactcaggcccaagctgtctGgctgtgcccaatgccaccgg	7	7	12	15	1	2	0	1	0	1	0	2	1	2	0	4	3	3	2	4	3	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:45354665G>C	uc002xsl.2	+	2	1087	c.990G>C	c.(988-990)CTG>CTC	p.L330L		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	330	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CAAGCTGTCTGGCTGTGCCCA	0.622													20	72					0	0	0	0	C	45354665	C	C	45354665	2	2	276	1	0	0	0	0	0	0	0	1	14603	1335	47	4		4	SLC2A10	20	45354665	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	603737	45354665	17670855	1975	51864											
ZMYND8	23613	broad.mit.edu	37	chr20	45874948	45874948	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgaaggttttgccttttcGgaaaagtccttctcaggctc	7	14	11	9	1	1	1	1	1	1	0	5	2	2	2	2	4	1	2	2	4	3	5	rs143651717	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:45874948G>A	uc002xta.1	-	14	2282	c.2028C>T	c.(2026-2028)TCC>TCT	p.S676S	ZMYND8_uc010ghq.1_Silent_p.S353S|ZMYND8_uc010ghr.1_Silent_p.S651S|ZMYND8_uc002xst.1_Silent_p.S604S|ZMYND8_uc002xsu.1_Silent_p.S676S|ZMYND8_uc002xsv.1_Silent_p.S604S|ZMYND8_uc002xsw.1_Silent_p.S428S|ZMYND8_uc002xsx.1_Silent_p.S428S|ZMYND8_uc002xsy.1_Silent_p.S651S|ZMYND8_uc002xsz.1_Silent_p.S613S|ZMYND8_uc010zxy.1_Silent_p.S703S|ZMYND8_uc002xtb.1_Silent_p.S696S|ZMYND8_uc002xss.2_Silent_p.S676S|ZMYND8_uc010zxz.1_Silent_p.S671S|ZMYND8_uc002xtc.1_Silent_p.S696S|ZMYND8_uc002xtd.1_Silent_p.S671S|ZMYND8_uc002xte.1_Silent_p.S676S|ZMYND8_uc010zya.1_Silent_p.S676S|ZMYND8_uc002xtf.1_Silent_p.S696S|ZMYND8_uc002xtg.2_Silent_p.S670S|ZMYND8_uc010ghs.1_Silent_p.S670S	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	676							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TTGCCTTTTCGGAAAAGTCCT	0.512													43	249					0	0	0	0	A	45874948	A	A	45874948	2	1	276	1	0	0	0	0	0	0	0	1	17778	1103	39	1		1	ZMYND8	20	45874948	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	520283	45874948	17150572	1976	51865											
ARFGEF2	10564	broad.mit.edu	37	chr20	47587686	47587687	+	Missense_Mutation	DNP	CC	TT	TT																															gctgcgttccaaggtggtttCcctgcagctgctcctctctg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:47587686_47587687CC>TT	uc002xtx.3	+	10	1372_1373	c.1220_1221CC>TT	c.(1219-1221)TCC>TTT	p.S407F		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	407					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AAGGTGGTTTCCCTGCAGCTGC	0.446													41	116					0	0	0	0	TT	47587687	TT	TT	47587686	3	4	276	1	0	0	0	0	1	0	0	0	853	855	30	2	1258	2	ARFGEF2	20	47587686	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	1712738	47587686	15437834	1977	51866											
KCNG1	3755	broad.mit.edu	37	chr20	49620884	49620884	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agcccaccagtagcaggcagGgatgctggtgaactcggggc	9	5	16	11	1	0	1	0	1	0	0	1	2	0	2	2	5	4	4	2	5	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:49620884G>A	uc002xwa.3	-	3	1529	c.1234C>T	c.(1234-1236)CCT>TCT	p.P412S		NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	412						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						TAGCAGGCAGGGATGCTGGTG	0.647													10	56					0	0	0	0	A	49620884	A	A	49620884	3	1	276	1	0	0	0	0	1	0	0	0	8066	1232	43	4	311	4	KCNG1	20	49620884	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2033198	49620884	13404636	1978	51867											
SALL4	57167	broad.mit.edu	37	chr20	50407413	50407413	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaggggtcccactcccttGgaagccaccagcccttgggg	6	7	12	16	0	1	0	1	0	0	0	3	1	3	1	5	5	2	0	5	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:50407413G>A	uc002xwh.3	-	2	1710	c.1609C>T	c.(1609-1611)CAA>TAA	p.Q537*	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	537					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CCACTCCCTTGGAAGCCACCA	0.582													86	124					0	0	0	0	A	50407413	A	A	50407413	4	1	276	1	0	0	0	0	0	1	0	0	13878	1357	47	4	1564	4	SALL4	20	50407413	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	786529	50407413	12618107	1979	51868											
ZBP1	81030	broad.mit.edu	37	chr20	56190040	56190040	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cggttcacatcttttgctgtCctcattcccagtgcttgggc	4	15	9	13	1	3	0	2	0	1	0	5	0	5	0	2	2	2	3	2	2	0	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:56190040C>A	uc002xyo.2	-	4	686	c.405G>T	c.(403-405)AGG>AGT	p.R135S	ZBP1_uc010gjm.2_Missense_Mutation_p.R135S|ZBP1_uc002xyp.2_Missense_Mutation_p.R60S|ZBP1_uc010zzn.1_Missense_Mutation_p.R135S	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	135	DRADA 2.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			CTTTTGCTGTCCTCATTCCCA	0.473													119	171					9.79165e-58	1.02356e-57	1	0	A	56190040	A	A	56190040	3	1	276	1	0	0	0	0	1	0	0	0	17588	854	30	2	981	2	ZBP1	20	56190040	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5782627	56190040	6835480	1980	51869											
VAPB	9217	broad.mit.edu	37	chr20	57015992	57015992	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaataaataaaattatatcCacaactgcatcaaagacaga	22	8	4	7	0	1	2	1	0	0	2	2	3	2	2	1	0	2	1	1	0	9	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:57015992C>T	uc002xza.2	+	5	697	c.426C>T	c.(424-426)TCC>TCT	p.S142S	VAPB_uc002xzb.2_RNA|VAPB_uc010zzo.1_Silent_p.S19S|VAPB_uc002xzc.2_Intron	NM_004738	NP_004729	O95292	VAPB_HUMAN	VAMP-associated protein B/C	142	Cytoplasmic (Potential).				cell death|endoplasmic reticulum unfolded protein response|positive regulation of viral genome replication|sphingolipid metabolic process|virus-host interaction	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	beta-tubulin binding|enzyme binding|protein heterodimerization activity|protein homodimerization activity|structural molecule activity			kidney(1)	1	Lung NSC(12;0.000615)|all_lung(29;0.00186)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;3.7e-08)|all cancers(14;3.88e-07)			AAATTATATCCACAACTGCAT	0.348													6	43					0	0	0	0	T	57015992	T	T	57015992	2	4	276	1	0	0	0	0	0	0	0	1	17190	581	21	4		4	VAPB	20	57015992	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	825952	57015992	6009528	1981	51870											
ZNF831	128611	broad.mit.edu	37	chr20	57767538	57767538	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccctcttcttccactccgtCcccactcagctctccaccac	5	10	2	24	1	4	0	1	0	3	0	8	0	7	0	8	0	1	1	8	0	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:57767538C>T	uc002yan.2	+	1	1464	c.1464C>T	c.(1462-1464)GTC>GTT	p.V488V		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	488						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCCACTCCGTCCCCACTCAGC	0.697													24	33					0	0	0	0	T	57767538	T	T	57767538	2	4	276	1	0	0	0	0	0	0	0	1	18252	842	30	2		2	ZNF831	20	57767538	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	751546	57767538	5257982	1982	51871											
C20orf197	284756	broad.mit.edu	37	chr20	58645826	58645826	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggacttctgcagtcaagaGagctgggaaactcttggaca	12	8	13	8	0	3	1	1	0	2	1	3	5	3	4	0	3	3	2	0	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:58645826G>A	uc002ybj.1	+	4	550	c.244G>A	c.(244-246)GAG>AAG	p.E82K		NM_173644	NP_775915	Q8N268	CT197_HUMAN	hypothetical protein LOC284756	82										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(7;2.33e-09)			GCAGTCAAGAGAGCTGGGAAA	0.269													5	57					0	0	0	0	A	58645826	A	A	58645826	3	1	276	1	0	0	0	0	1	0	0	0	2112	943	33	2	250	2	C20orf197	20	58645826	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	878288	58645826	4379694	1983	51872											
C20orf151	140893	broad.mit.edu	37	chr20	60987714	60987714	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tccgaggcccgcttcctcttCcgtggtggaccctgcccgtg	2	10	12	17	4	1	0	0	0	1	0	4	2	4	1	6	3	1	1	6	3	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:60987714C>T	uc002ycw.1	-	13	1999	c.1842G>A	c.(1840-1842)CGG>CGA	p.R614R		NM_080833	NP_543023	Q8NC74	CT151_HUMAN	hypothetical protein LOC140893	614											0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;6.43e-06)			GCTTCCTCTTCCGTGGTGGAC	0.701													12	102					0	0	0	0	T	60987714	T	T	60987714	2	4	276	1	0	0	0	0	0	0	0	1	2101	842	30	2		2	C20orf151	20	60987714	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2341888	60987714	2037806	1984	51873											
COL9A3	1299	broad.mit.edu	37	chr20	61451328	61451328	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggacccaagggtgcccctggGgaacgggtaagtgcctgcgc	7	5	17	12	2	0	0	0	0	0	0	0	2	0	2	4	5	4	1	4	5	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:61451328G>A	uc002ydm.2	+	5	306	c.303G>A	c.(301-303)GGG>GGA	p.G101G		NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	101	Triple-helical region 3 (COL3).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					GTGCCCCTGGGGAACGGGTAA	0.662													10	88					0	0	0	0	A	61451328	A	A	61451328	2	1	276	1	0	0	0	0	0	0	0	1	3724	1219	43	4		4	COL9A3	20	61451328	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	463614	61451328	1574192	1985	51874											
DIDO1	11083	broad.mit.edu	37	chr20	61511582	61511583	+	Missense_Mutation	DNP	GG	AA	AA																															tctgacctccaaactgagagGgaggggggccgcctcggggg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:61511582_61511583GG>AA	uc002ydr.1	-	16	5989_5990	c.5725_5726CC>TT	c.(5725-5727)CCC>TTC	p.P1909F	DIDO1_uc002yds.1_Missense_Mutation_p.P1909F	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1909	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					AAACTGAGAGGGAGGGGGGCCG	0.644													16	74					0	0	0	0	AA	61511583	AA	AA	61511582	3	1	276	1	0	0	0	0	1	0	0	0	4544	1232	43	4	1000	4	DIDO1	20	61511582	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	60254	61511582	1513938	1986	51875											
COL20A1	57642	broad.mit.edu	37	chr20	61950421	61950421	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccacagtgacgtctaccCagcccccctacctccagagc	8	5	6	22	1	1	2	0	1	1	1	2	2	2	2	8	0	4	0	8	0	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:61950421C>T	uc011aau.1	+	22	2775	c.2675C>T	c.(2674-2676)CCA>CTA	p.P892L	COL20A1_uc011aav.1_Missense_Mutation_p.P713L	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	892	TSP N-terminal.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					GACGTCTACCCAGCCCCCCTA	0.657													12	47					0	0	0	0	T	61950421	T	T	61950421	3	4	276	1	0	0	0	0	1	0	0	0	3694	594	21	4	2757	4	COL20A1	20	61950421	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	438839	61950421	1075099	1987	51876											
CHRNA4	1137	broad.mit.edu	37	chr20	61978201	61978201	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgaccatggccacgtacttCcagtcctccttcacctgcaa	9	10	6	16	1	1	1	1	1	0	0	4	1	4	1	6	1	2	2	6	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:61978201C>T	uc002yes.2	-	6	1951	c.1773G>A	c.(1771-1773)TGG>TGA	p.W591*	CHRNA4_uc002yet.1_Nonsense_Mutation_p.W415*|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Nonsense_Mutation_p.W520*|CHRNA4_uc002yev.1_Nonsense_Mutation_p.W415*|CHRNA4_uc010gkf.1_Nonsense_Mutation_p.W415*	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	591	Cytoplasmic (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CCACGTACTTCCAGTCCTCCT	0.682													41	48					0	0	0	0	T	61978201	T	T	61978201	4	4	276	1	0	0	0	0	0	1	0	0	3400	856	30	2	114	2	CHRNA4	20	61978201	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	27780	61978201	1047319	1988	51877											
CHRNA4	1137	broad.mit.edu	37	chr20	61981710	61981710	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaggagcaggcgtggcacGatgtccaggaagaccctgcg	10	5	16	10	3	0	2	0	1	0	1	1	5	1	4	2	4	2	2	2	4	1	0	rs61737042	byFrequency	TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:61981710G>A	uc002yes.2	-	5	1231	c.1053C>T	c.(1051-1053)ATC>ATT	p.I351I	CHRNA4_uc002yet.1_Silent_p.I175I|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.I280I|CHRNA4_uc002yev.1_Silent_p.I175I|CHRNA4_uc010gkf.1_Silent_p.I175I	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	351	Cytoplasmic (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	GGCGTGGCACGATGTCCAGGA	0.632													32	34					0	0	0	0	A	61981710	A	A	61981710	2	1	276	1	0	0	0	0	0	0	0	1	3400	1048	37	1		1	CHRNA4	20	61981710	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3509	61981710	1043810	1989	51878											
PRIC285	85441	broad.mit.edu	37	chr20	62196773	62196773	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgctcgaaggtctctggcacGaaagagcagtggcggtaccg	9	6	15	11	5	1	1	0	0	1	1	3	3	1	1	1	4	2	4	1	4	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:62196773G>A	uc002yfm.2	-	9	4294	c.3402C>T	c.(3400-3402)TTC>TTT	p.F1134F	PRIC285_uc002yfl.1_Silent_p.F565F	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1134					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TCTCTGGCACGAAAGAGCAGT	0.701													6	24					0	0	0	0	A	62196773	A	A	62196773	2	1	276	1	0	0	0	0	0	0	0	1	12547	1049	37	1		1	PRIC285	20	62196773	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	215063	62196773	828747	1990	51879											
PRPF6	24148	broad.mit.edu	37	chr20	62630979	62630979	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatcaagaaggcgcgactgcTcctcaagtctgttcgggaga	10	9	12	10	3	3	2	2	0	1	2	5	4	4	2	1	2	1	2	1	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr20:62630979T>A	uc002yho.2	+	8	1058	c.890T>A	c.(889-891)CTC>CAC	p.L297H	PRPF6_uc002yhp.2_Missense_Mutation_p.L297H	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	297					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GCGCGACTGCTCCTCAAGTCT	0.592													23	113					0	0	0	0	A	62630979	A	A	62630979	3	1	276	1	0	0	0	0	1	0	0	0	12636	1551	54	5	920	5	PRPF6	20	62630979	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	434206	62630979	394541	1991	51880											
TPTE	7179	broad.mit.edu	37	chr21	10910350	10910350	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catcatcatacagaggtagaCcgtcgaatacatcaattaat	16	10	6	9	2	3	2	3	0	0	2	4	3	3	2	1	1	2	1	1	1	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:10910350C>T	uc002yip.1	-	22	1774	c.1406G>A	c.(1405-1407)GGT>GAT	p.G469D	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.G451D|TPTE_uc002yir.1_Missense_Mutation_p.G431D|TPTE_uc010gkv.1_Missense_Mutation_p.G331D	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	469	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAGAGGTAGACCGTCGAATAC	0.343													7	80					0	0	0	0	T	10910350	T	T	10910350	3	4	276	1	0	0	0	0	1	0	0	0	16497	507	18	4	261	4	TPTE	21	10910350	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08		10910350	37219545	1992	51881											
SAMSN1	64092	broad.mit.edu	37	chr21	15858399	15858399	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggagatgtctgagctcaagGataggggctcaggttcattt	10	11	14	6	0	4	2	3	1	1	1	4	4	4	3	0	5	1	3	0	5	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:15858399G>A	uc002yju.1	-	8	1038	c.956C>T	c.(955-957)TCC>TTC	p.S319F	SAMSN1_uc010gky.1_Missense_Mutation_p.S151F|SAMSN1_uc002yjv.1_Missense_Mutation_p.S387F	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	319					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		TGAGCTCAAGGATAGGGGCTC	0.393													6	30					0	0	0	0	A	15858399	A	A	15858399	3	1	276	1	0	0	0	0	1	0	0	0	13895	1174	41	2	169	2	SAMSN1	21	15858399	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	4948049	15858399	32271496	1993	51882											
NCAM2	4685	broad.mit.edu	37	chr21	22841080	22841080	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatggaggggcccctattttGgaatacattgtgaaatatag	12	12	12	5	0	0	1	0	1	0	0	0	4	0	3	2	4	1	0	2	4	6	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:22841080G>A	uc002yld.1	+	14	2121	c.1872G>A	c.(1870-1872)TTG>TTA	p.L624L	NCAM2_uc011acb.1_Silent_p.L482L	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	624	Fibronectin type-III 2.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CCCCTATTTTGGAATACATTG	0.378													8	23					0	0	0	0	A	22841080	A	A	22841080	2	1	276	1	0	0	0	0	0	0	0	1	10257	1339	47	4		4	NCAM2	21	22841080	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6982681	22841080	25288815	1994	51883											
GRIK1	2897	broad.mit.edu	37	chr21	30927416	30927416	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgatttgtatatgaattctCcaatagctacaaatacagaa	16	13	6	6	0	1	3	0	2	1	1	2	3	1	3	1	0	3	2	1	0	9	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:30927416C>T	uc002yno.1	-	16	3028	c.2564G>A	c.(2563-2565)GGA>GAA	p.G855E	GRIK1_uc002ynn.2_Missense_Mutation_p.G840E|GRIK1_uc011acs.1_Missense_Mutation_p.G855E|GRIK1_uc011act.1_Missense_Mutation_p.G716E	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	855	Helical; (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TATGAATTCTCCAATAGCTAC	0.398													13	45					0	0	0	0	T	30927416	T	T	30927416	3	4	276	1	0	0	0	0	1	0	0	0	6812	855	30	2	360	2	GRIK1	21	30927416	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	8086336	30927416	17202479	1995	51884											
GRIK1	2897	broad.mit.edu	37	chr21	30963489	30963489	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatcagtgatattgctggaCttgtctttgttgctgtccgt	6	17	11	7	1	2	1	1	1	1	0	3	3	3	2	1	1	2	3	1	1	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:30963489C>A	uc002yno.1	-	10	1772	c.1308G>T	c.(1306-1308)AAG>AAT	p.K436N	GRIK1_uc002ynn.2_Missense_Mutation_p.K421N|GRIK1_uc011acs.1_Missense_Mutation_p.K436N|GRIK1_uc011act.1_Missense_Mutation_p.K365N|GRIK1_uc010glq.1_Missense_Mutation_p.K279N	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	436	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TATTGCTGGACTTGTCTTTGT	0.463													23	71					1.42536e-11	1.46167e-11	1	0	A	30963489	A	A	30963489	3	1	276	1	0	0	0	0	1	0	0	0	6812	564	20	4	1640	4	GRIK1	21	30963489	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	36073	30963489	17166406	1996	51885											
KRTAP13-1	140258	broad.mit.edu	37	chr21	31768437	31768437	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgctctggaaacttctcCtcccgctcctgtggtggcta	4	13	10	14	1	2	0	0	0	2	0	5	1	4	1	3	3	3	4	3	3	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:31768437C>T	uc002yoa.2	+	1	46	c.33C>T	c.(31-33)TCC>TCT	p.S11S		NM_181599	NP_853630	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	11						intermediate filament				ovary(1)	1						GAAACTTCTCCTCCCGCTCCT	0.537													43	128					0	0	0	0	T	31768437	T	T	31768437	2	4	276	1	0	0	0	0	0	0	0	1	8561	668	24	4		4	KRTAP13-1	21	31768437	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	804948	31768437	16361458	1997	51886											
KRTAP19-4	337971	broad.mit.edu	37	chr21	31869219	31869219	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttcttatgacctctgatatCgtgtcctcagggtaggattt	7	16	9	9	1	3	2	1	2	2	0	5	3	4	3	2	2	0	1	2	2	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:31869219C>T	uc011acz.1	-	1	210	c.210G>A	c.(208-210)ACG>ACA	p.T70T		NM_181610	NP_853641	Q3LI73	KR194_HUMAN	keratin associated protein 19-4	70						intermediate filament				ovary(2)	2						CCTCTGATATCGTGTCCTCAG	0.408													33	101					0	0	0	0	T	31869219	T	T	31869219	2	4	276	1	0	0	0	0	0	0	0	1	8570	871	31	1		1	KRTAP19-4	21	31869219	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	100782	31869219	16260676	1998	51887											
KRTAP19-7	337974	broad.mit.edu	37	chr21	31933443	31933443	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaatccagaagaccagtatcCcccatagcatgatgggtggc	12	7	11	11	0	0	3	0	1	0	2	2	4	2	3	4	2	1	2	4	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:31933443C>T	uc011adb.1	-	1	166	c.166G>A	c.(166-168)GGA>AGA	p.G56R		NM_181614	NP_853645	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	56						intermediate filament					0						GACCAGTATCCCCCATAGCAT	0.443													25	92					0	0	0	0	T	31933443	T	T	31933443	3	4	276	1	0	0	0	0	1	0	0	0	8573	632	22	4	28	4	KRTAP19-7	21	31933443	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	64224	31933443	16196452	1999	51888											
KRTAP20-1	337975	broad.mit.edu	37	chr21	31988934	31988934	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggaagatattggtcatatgGtttctactgaacaattctag	12	15	9	5	0	3	2	1	1	2	1	3	3	3	3	0	3	2	1	0	3	7	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:31988934G>T	uc011ade.1	+	1	161	c.161G>T	c.(160-162)GGT>GTT	p.G54V	KRTAP6-1_uc002yop.2_5'Flank	NM_181615	NP_853646	Q3LI63	KR201_HUMAN	keratin associated protein 20-1	54						intermediate filament				breast(1)	1						TGGTCATATGGTTTCTACTGA	0.448													26	61					4.7796e-09	4.87966e-09	1	0	T	31988934	T	T	31988934	3	4	276	1	0	0	0	0	1	0	0	0	8575	1261	44	4	163	4	KRTAP20-1	21	31988934	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	55491	31988934	16140961	2000	51889											
SFRS15	57466	broad.mit.edu	37	chr21	33067280	33067280	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcctggcatttgtccattaGgaggaagtggaacctttcat	10	13	10	8	0	1	0	1	0	0	0	3	3	3	3	3	4	1	1	3	4	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:33067280G>A	uc002ypd.2	-	10	1508	c.1082C>T	c.(1081-1083)CCT>CTT	p.P361L	SFRS15_uc002ype.2_Missense_Mutation_p.P361L|SFRS15_uc010glu.2_Missense_Mutation_p.P346L|SFRS15_uc002ypf.1_Missense_Mutation_p.P35L	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	361						nucleus	nucleotide binding|RNA binding				0						TTGTCCATTAGGAGGAAGTGG	0.388													16	40					0	0	0	0	A	33067280	A	A	33067280	3	1	276	1	0	0	0	0	1	0	0	0	14236	1000	35	4	2405	4	SFRS15	21	33067280	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1078346	33067280	15062615	2001	51890											
C21orf59	56683	broad.mit.edu	37	chr21	33954558	33954558	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggacgctgcagatttcttCctggctttccaccgctgcag	5	11	12	13	2	1	1	0	0	1	1	3	2	3	2	3	3	2	5	3	3	0	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:33954558C>T	uc002ypy.1	-	7	1043	c.930G>A	c.(928-930)AGG>AGA	p.R310R	TCP10L_uc002ypw.3_Silent_p.R104R|C21orf59_uc002ypx.1_Silent_p.R127R|C21orf59_uc002ypz.1_Silent_p.R278R	NM_021254	NP_067077	P57076	CU059_HUMAN	hypothetical protein LOC56683	Error:Variant_position_missing_in_P57076_after_alignment						cytosol|nucleus					0						CAGATTTCTTCCTGGCTTTCC	0.493													27	96					0	0	0	0	T	33954558	T	T	33954558	2	4	276	1	0	0	0	0	0	0	0	1	2140	854	30	2		2	C21orf59	21	33954558	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	887278	33954558	14175337	2002	51891											
IFNAR1	3454	broad.mit.edu	37	chr21	34727665	34727665	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatcttctgctttcaacttCtgaggaacaaatcgaaaaat	15	12	6	8	1	4	1	1	1	3	0	5	4	4	2	0	1	3	1	0	1	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:34727665C>T	uc002yrn.2	+	11	1631	c.1484C>T	c.(1483-1485)TCT>TTT	p.S495F	IFNAR1_uc011adv.1_Missense_Mutation_p.S426F	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	495	Cytoplasmic (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	CTTTCAACTTCTGAGGAACAA	0.264													14	51					0	0	0	0	T	34727665	T	T	34727665	3	4	276	1	0	0	0	0	1	0	0	0	7583	913	32	2	1526	2	IFNAR1	21	34727665	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	773107	34727665	13402230	2003	51892											
SON	6651	broad.mit.edu	37	chr21	34921999	34921999	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atagatttagaatctgattcCtttttaaagtttgattctga	12	19	6	4	0	2	5	0	3	2	2	3	5	3	5	1	0	0	1	1	0	5	9			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:34921999C>T	uc002yse.1	+	3	511	c.462C>T	c.(460-462)TCC>TCT	p.S154S	SON_uc002ysb.1_Silent_p.S154S|SON_uc002ysc.2_Silent_p.S154S|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	154					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						AATCTGATTCCTTTTTAAAGT	0.373													4	25					0	0	0	0	T	34921999	T	T	34921999	2	4	276	1	0	0	0	0	0	0	0	1	14990	668	24	4		4	SON	21	34921999	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	194334	34921999	13207896	2004	51893											
DONSON	29980	broad.mit.edu	37	chr21	34957051	34957051	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctctgctggaaggtacaacgGagctcagaggagagtttggg	10	8	16	7	1	2	2	1	0	1	2	2	5	2	4	0	5	4	4	0	5	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:34957051G>A	uc002ysk.2	-	4	697	c.630C>T	c.(628-630)CTC>CTT	p.L210L	DONSON_uc002ysn.1_Silent_p.L93L|DONSON_uc002ysi.1_Intron|DONSON_uc002ysj.2_5'UTR|DONSON_uc002ysl.2_5'UTR|DONSON_uc010gme.2_Silent_p.L183L|DONSON_uc002ysm.2_Silent_p.L210L	NM_017613	NP_060083	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	210					multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2						AGGTACAACGGAGCTCAGAGG	0.438													13	28					0	0	0	0	A	34957051	A	A	34957051	2	1	276	1	0	0	0	0	0	0	0	1	4728	1161	41	2		2	DONSON	21	34957051	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	35052	34957051	13172844	2005	51894											
DOPEY2	9980	broad.mit.edu	37	chr21	37618783	37618783	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccagggtcttctggtctctgCggtggtgaggggtctgcagc	3	11	17	10	1	4	1	0	1	4	0	5	1	4	1	1	6	3	1	1	6	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:37618783C>T	uc002yvg.2	+	19	4584	c.4505C>T	c.(4504-4506)GCG>GTG	p.A1502V	DOPEY2_uc011aeb.1_Missense_Mutation_p.A1451V|DOPEY2_uc002yvh.2_Missense_Mutation_p.A353V	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1502					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CTGGTCTCTGCGGTGGTGAGG	0.652													5	36					0	0	0	0	T	37618783	T	T	37618783	3	4	276	1	0	0	0	0	1	0	0	0	4730	768	27	1	4575	1	DOPEY2	21	37618783	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2661732	37618783	10511112	2006	51895											
TTC3	7267	broad.mit.edu	37	chr21	38461125	38461125	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtgcttctgagataaattTgaagaaactacaacatcttg	15	12	7	7	1	2	3	0	2	2	2	2	4	2	3	0	0	4	1	0	0	6	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:38461125T>C	uc002yvz.2	+	5	470	c.365T>C	c.(364-366)TTG>TCG	p.L122S	TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Missense_Mutation_p.L122S|TTC3_uc002ywb.2_Missense_Mutation_p.L122S|TTC3_uc010gnf.2_5'UTR|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Missense_Mutation_p.L122S	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	122					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				GAGATAAATTTGAAGAAACTA	0.328													7	25					0	0	0	0	C	38461125	C	C	38461125	3	2	276	1	0	0	0	0	1	0	0	0	16765	1821	63	5	379	5	TTC3	21	38461125	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	842342	38461125	9668770	2007	51896											
TTC3	7267	broad.mit.edu	37	chr21	38538152	38538152	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caactgaatccagctgctagGgaatttaaaccagatgtaaa	16	9	8	8	0	0	2	0	1	0	1	1	3	1	3	2	1	4	3	2	1	8	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:38538152G>A	uc002yvz.2	+	33	3741	c.3636G>A	c.(3634-3636)AGG>AGA	p.R1212R	TTC3_uc011aee.1_Silent_p.R902R|TTC3_uc002ywa.2_Silent_p.R1212R|TTC3_uc002ywb.2_Silent_p.R1212R|TTC3_uc010gnf.2_Silent_p.R977R|TTC3_uc002ywc.2_Silent_p.R902R|TTC3_uc002ywd.1_Silent_p.R276R	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1212					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				CAGCTGCTAGGGAATTTAAAC	0.363													20	51					0	0	0	0	A	38538152	A	A	38538152	2	1	276	1	0	0	0	0	0	0	0	1	16765	1223	43	4		4	TTC3	21	38538152	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	77027	38538152	9591743	2008	51897											
DSCAM	1826	broad.mit.edu	37	chr21	42080587	42080587	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccatctgagagtcacaggagGgatgcctgctgcggggcagg	8	6	17	10	1	2	1	1	1	1	1	2	4	2	3	2	5	3	2	2	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:42080587G>A	uc002yyq.1	-	2	606	c.154C>T	c.(154-156)CCT>TCT	p.P52S	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	52	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTCACAGGAGGGATGCCTGCT	0.592													21	78					0	0	0	0	A	42080587	A	A	42080587	3	1	276	1	0	0	0	0	1	0	0	0	4790	1232	43	4	6012	4	DSCAM	21	42080587	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3542435	42080587	6049308	2009	51898											
ABCG1	9619	broad.mit.edu	37	chr21	43708321	43708321	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctcttgcgtgtgtcctcagGactcctcgtccatggaaggc	5	11	11	14	2	2	0	1	0	1	0	6	2	5	2	4	3	1	0	4	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:43708321G>A	uc002zaq.2	+	10	1265	c.1159G>A	c.(1159-1161)GAC>AAC	p.D387N	ABCG1_uc002zan.2_Missense_Mutation_p.D377N|ABCG1_uc002zam.2_Missense_Mutation_p.D353N|ABCG1_uc002zao.2_Missense_Mutation_p.D372N|ABCG1_uc002zap.2_Missense_Mutation_p.D375N|ABCG1_uc002zar.2_Missense_Mutation_p.D386N|ABCG1_uc011aev.1_Missense_Mutation_p.D398N|ABCG1_uc010gpb.1_Missense_Mutation_p.G27E	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	387	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	GTGTCCTCAGGACTCCTCGTC	0.602													16	29					0	0	0	0	A	43708321	A	A	43708321	3	1	276	1	0	0	0	0	1	0	0	0	68	1188	41	2	1365	2	ABCG1	21	43708321	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1627734	43708321	4421574	2010	51899											
RRP1	8568	broad.mit.edu	37	chr21	45213238	45213238	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccttctggcagaccatgaatCgcgagtggacgggcattgac	9	8	13	11	3	1	3	0	2	1	1	2	5	1	4	2	3	0	2	2	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:45213238C>T	uc002zds.2	+	4	406	c.313C>T	c.(313-315)CGC>TGC	p.R105C	RRP1_uc011aez.1_Missense_Mutation_p.R105C|RRP1_uc010gpk.1_5'UTR|RRP1_uc010gpl.1_Missense_Mutation_p.R3C	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	105					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		GACCATGAATCGCGAGTGGAC	0.617													23	86					0	0	0	0	T	45213238	T	T	45213238	3	4	276	1	0	0	0	0	1	0	0	0	13750	884	31	1	327	1	RRP1	21	45213238	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1504917	45213238	2916657	2011	51900											
DNMT3L	29947	broad.mit.edu	37	chr21	45668976	45668976	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggatccgccgtggacatctgGgatggtgactggctccatct	6	10	14	11	2	2	1	0	1	2	0	4	4	4	4	3	5	0	1	3	5	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:45668976G>A	uc002zeg.1	-	11	1412	c.928C>T	c.(928-930)CCA>TCA	p.P310S	DNMT3L_uc002zeh.1_Missense_Mutation_p.P310S	NM_175867	NP_787063	Q9UJW3	DNM3L_HUMAN	cytosine-5-methyltransferase 3-like protein	310					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			skin(2)	2				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		TGGACATCTGGGATGGTGACT	0.642													6	21					0	0	0	0	A	45668976	A	A	45668976	3	1	276	1	0	0	0	0	1	0	0	0	4700	1232	43	4	243	4	DNMT3L	21	45668976	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	455738	45668976	2460919	2012	51901											
AIRE	326	broad.mit.edu	37	chr21	45708290	45708290	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtcctccggggacgtcccgGgagcccgaggggccgtggag	4	5	19	13	5	0	0	0	0	0	0	3	4	3	3	5	6	1	0	5	6	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:45708290G>A	uc002zei.2	+	5	728	c.601G>A	c.(601-603)GGA>AGA	p.G201R	AIRE_uc010gpq.2_5'Flank|AIRE_uc002zej.2_5'Flank|AIRE_uc010gpr.2_5'Flank	NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	201	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		GGACGTCCCGGGAGCCCGAGG	0.642									Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				19	73					0	0	0	0	A	45708290	A	A	45708290	3	1	276	1	0	0	0	0	1	0	0	0	437	1233	43	4	619	4	AIRE	21	45708290	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	39314	45708290	2421605	2013	51902											
TRPM2	7226	broad.mit.edu	37	chr21	45833900	45833900	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgacggtcctcctactctGcctctacctgctcttcacca	5	12	6	18	1	4	1	1	1	3	0	6	1	6	1	5	1	4	2	5	1	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:45833900G>T	uc002zet.1	+	21	3302	c.3089G>T	c.(3088-3090)TGC>TTC	p.C1030F	TRPM2_uc002zeu.1_Missense_Mutation_p.C1030F|TRPM2_uc002zew.1_Missense_Mutation_p.C1030F|TRPM2_uc010gpt.1_Missense_Mutation_p.C1030F|TRPM2_uc002zex.1_Missense_Mutation_p.C816F|TRPM2_uc002zey.1_Missense_Mutation_p.C543F	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1030	Helical; (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTCCTACTCTGCCTCTACCTG	0.647													56	246					9.04393e-38	9.43456e-38	1	0	T	45833900	T	T	45833900	3	4	276	1	0	0	0	0	1	0	0	0	16653	1319	46	4	3167	4	TRPM2	21	45833900	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	125610	45833900	2295995	2014	51903											
KRTAP10-4	386672	broad.mit.edu	37	chr21	45993969	45993969	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gccagcaggcctgctgcgtgCccgtctgctgcaagactgtc	5	8	13	15	2	1	1	0	0	1	1	2	1	1	1	3	1	6	4	3	1	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:45993969C>T	uc002zfk.1	+	1	364	c.334C>T	c.(334-336)CCC>TCC	p.P112S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	112	36 X 5 AA repeats of C-C-X(3).|7.					keratin filament					0						CTGCTGCGTGCCCGTCTGCTG	0.637													11	67					0	0	0	0	T	45993969	T	T	45993969	3	4	276	1	0	0	0	0	1	0	0	0	8550	739	26	4	336	4	KRTAP10-4	21	45993969	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	160069	45993969	2135926	2015	51904											
KRTAP12-3	386683	broad.mit.edu	37	chr21	46078117	46078117	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tccctcttgccaatcttcggGgtgctgccagcccccctgca	4	10	9	18	1	2	0	0	0	2	0	4	0	3	0	6	2	5	2	6	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:46078117G>A	uc002zft.2	+	1	269	c.221G>A	c.(220-222)GGG>GAG	p.G74E	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198697	NP_941970	P60328	KR123_HUMAN	keratin associated protein 12-3	74	10.|14 X 5 AA approximate repeats.					intermediate filament				central_nervous_system(1)	1						CAATCTTCGGGGTGCTGCCAG	0.642													28	59					0	0	0	0	A	46078117	A	A	46078117	3	1	276	1	0	0	0	0	1	0	0	0	8559	1232	43	4	223	4	KRTAP12-3	21	46078117	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	84148	46078117	2051778	2016	51905											
ITGB2	3689	broad.mit.edu	37	chr21	46326992	46326992	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcagcgaatggagtcaggatCccccggccctgtgaagttct	8	8	13	12	2	2	1	1	1	1	0	3	4	3	3	3	3	1	2	3	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:46326992C>T	uc002zgd.2	-	3	210	c.166G>A	c.(166-168)GAT>AAT	p.D56N	ITGB2_uc002zge.2_Missense_Mutation_p.D56N|ITGB2_uc002zgf.3_Missense_Mutation_p.D56N|ITGB2_uc011afl.1_5'UTR|ITGB2_uc010gpw.2_Missense_Mutation_p.D56N|ITGB2_uc002zgg.2_Missense_Mutation_p.D56N	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	56	Extracellular (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GAGTCAGGATCCCCCGGCCCT	0.657													20	43					0	0	0	0	T	46326992	T	T	46326992	3	4	276	1	0	0	0	0	1	0	0	0	7933	855	30	2	2195	2	ITGB2	21	46326992	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	248875	46326992	1802903	2017	51906											
ADARB1	104	broad.mit.edu	37	chr21	46596324	46596324	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccgagtgggaagaatccCgtgatgatcttgaacgaact	11	8	11	11	3	1	4	0	3	1	1	2	7	2	5	3	1	2	0	3	1	4	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:46596324C>T	uc002zgy.2	+	4	1143	c.708C>T	c.(706-708)CCC>CCT	p.P236P	ADARB1_uc002zgr.2_Silent_p.P236P|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Silent_p.P236P|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Silent_p.P236P|ADARB1_uc010gpx.2_Intron|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA|ADARB1_uc011afo.1_Silent_p.P285P	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	236	DRBM 2.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		GGAAGAATCCCGTGATGATCT	0.607													21	44					0	0	0	0	T	46596324	T	T	46596324	2	4	276	1	0	0	0	0	0	0	0	1	282	639	23	1		1	ADARB1	21	46596324	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	269332	46596324	1533571	2018	51907											
SLC19A1	6573	broad.mit.edu	37	chr21	46950872	46950872	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcacgaagcccgcggcgaaGgacgtgatggcgcctgagag	9	5	16	11	6	1	2	1	2	0	1	1	6	1	3	2	3	1	0	2	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:46950872G>A	uc002zhl.1	-	4	1082	c.963C>T	c.(961-963)TCC>TCT	p.S321S	SLC19A1_uc010gpy.1_Silent_p.S321S|SLC19A1_uc011aft.1_Silent_p.S281S|SLC19A1_uc002zhm.1_Silent_p.S321S|SLC19A1_uc010gpz.1_Silent_p.S200S	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	321	Helical; (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		CCGCGGCGAAGGACGTGATGG	0.706													3	12					0	0	0	0	A	46950872	A	A	46950872	2	1	276	1	0	0	0	0	0	0	0	1	14493	987	35	4		4	SLC19A1	21	46950872	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	354548	46950872	1179023	2019	51908											
SLC19A1	6573	broad.mit.edu	37	chr21	46951419	46951419	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaccaggtagtagccggccGagttgaagacccaccagagg	11	4	13	13	2	0	3	0	1	0	2	0	4	0	3	6	3	1	3	6	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr21:46951419G>A	uc002zhl.1	-	3	952	c.833C>T	c.(832-834)TCG>TTG	p.S278L	SLC19A1_uc010gpy.1_Missense_Mutation_p.S278L|SLC19A1_uc011aft.1_Missense_Mutation_p.S238L|SLC19A1_uc002zhm.1_Missense_Mutation_p.S278L|SLC19A1_uc010gpz.1_Missense_Mutation_p.S157L	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	278	Helical; (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GTAGCCGGCCGAGTTGAAGAC	0.672													35	61					0	0	0	0	A	46951419	A	A	46951419	3	1	276	1	0	0	0	0	1	0	0	0	14493	1059	37	1	958	1	SLC19A1	21	46951419	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	547	46951419	1178476	2020	51909											
IL17RA	23765	broad.mit.edu	37	chr22	17588619	17588619	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atttcttttcctttccagggCctggaagtgaaaaatacagt	11	14	8	8	0	1	1	0	1	1	0	3	2	3	2	3	2	1	0	3	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:17588619C>T	uc002zly.2	+	12	1181	c.1048C>T	c.(1048-1050)CCT>TCT	p.P350S	IL17RA_uc010gqt.2_Intron	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	350	Cytoplasmic (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		CTTTCCAGGGCCTGGAAGTGA	0.463													5	41					0	0	0	0	T	17588619	T	T	17588619	3	4	276	1	0	0	0	0	1	0	0	0	7678	739	26	4	1094	4	IL17RA	22	17588619	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08		17588619	33715947	2021	51910											
CECR2	27443	broad.mit.edu	37	chr22	17976490	17976490	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaactaccgctgggagctcGaagaagggaagcccaaccct	12	5	11	13	2	1	1	1	0	0	1	2	4	1	3	3	2	5	2	3	2	6	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:17976490G>A	uc010gqw.1	+	2	277	c.151G>A	c.(151-153)GAA>AAA	p.E51K	CECR2_uc010gqv.1_5'UTR|CECR2_uc002zml.2_5'UTR|CECR2_uc002zmm.1_5'Flank	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	93					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		CTGGGAGCTCGAAGAAGGGAA	0.517													20	19					0	0	0	0	A	17976490	A	A	17976490	3	1	276	1	0	0	0	0	1	0	0	0	3221	1059	37	1	159	1	CECR2	22	17976490	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	387871	17976490	33328076	2022	51911											
MICAL3	57553	broad.mit.edu	37	chr22	18300221	18300221	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggacttccacagggacttggGtttggcggcggcttcttcta	5	12	14	10	2	2	0	0	0	2	0	3	2	3	2	1	6	0	2	1	6	1	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:18300221G>A	uc002zng.3	-	26	5559	c.5206C>T	c.(5206-5208)CCC>TCC	p.P1736S	MICAL3_uc011agl.1_Missense_Mutation_p.P1652S|MICAL3_uc010gre.1_5'Flank	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1736						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		AGGGACTTGGGTTTGGCGGCG	0.622													9	31					0	0	0	0	A	18300221	A	A	18300221	3	1	276	1	0	0	0	0	1	0	0	0	9624	1261	44	4	830	4	MICAL3	22	18300221	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	323731	18300221	33004345	2023	51912											
CLTCL1	8218	broad.mit.edu	37	chr22	19217372	19217372	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcactgacctggggtgcatGaacaaggttcatctccaaca	11	9	10	11	0	3	2	2	2	1	0	4	2	3	2	2	3	3	2	2	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:19217372G>A	uc002zpb.2	-	11	1846	c.1771C>T	c.(1771-1773)CAT>TAT	p.H591Y	CLTCL1_uc011agv.1_Missense_Mutation_p.H591Y|CLTCL1_uc011agw.1_Missense_Mutation_p.H591Y	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	591	Distal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TGGGGTGCATGAACAAGGTTC	0.512			T	?	ALCL								4	11					0	0	0	0	A	19217372	A	A	19217372	3	1	276	1	0	0	0	0	1	0	0	0	3582	1290	45	2	3239	2	CLTCL1	22	19217372	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	917151	19217372	32087194	2024	51913											
HIRA	7290	broad.mit.edu	37	chr22	19344534	19344534	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgaccacaggtggagaacaCtgacagcatccttttttcac	11	9	9	12	1	1	2	1	1	0	1	2	4	2	2	2	2	2	1	2	2	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:19344534C>G	uc002zpf.1	-	19	2495	c.2275G>C	c.(2275-2277)GTG>CTG	p.V759L	HIRA_uc011agx.1_Missense_Mutation_p.V625L|HIRA_uc010grn.1_Intron|HIRA_uc010gro.1_Missense_Mutation_p.V715L|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	759	Interaction with PAX3 (By similarity).|Interaction with histone H2B.|Interaction with histone H4.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					GTGGAGAACACTGACAGCATC	0.587													33	125					0	0	0	0	G	19344534	G	G	19344534	3	3	276	1	0	0	0	0	1	0	0	0	7159	565	20	4	806	4	HIRA	22	19344534	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	127162	19344534	31960032	2025	51914											
UFD1L	7353	broad.mit.edu	37	chr22	19444407	19444407	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	catgctggacttgtctttcgGgttctttgtagcccagggga	5	14	13	9	1	2	0	0	0	2	0	3	2	2	2	1	4	2	3	1	4	1	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:19444407G>A	uc002zpm.2	-	8	729	c.599C>T	c.(598-600)CCC>CTC	p.P200L	UFD1L_uc002zpo.2_Missense_Mutation_p.P200L|UFD1L_uc011agy.1_Missense_Mutation_p.P200L|UFD1L_uc002zpp.2_Missense_Mutation_p.P153L	NM_005659	NP_005650	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1-like isoform A	200					skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity				0	Colorectal(54;0.0993)					Ttgtctttcgggttctttgta	0.313													7	11					0	0	0	0	A	19444407	A	A	19444407	3	1	276	1	0	0	0	0	1	0	0	0	17003	1232	43	4	344	4	UFD1L	22	19444407	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	99873	19444407	31860159	2026	51915											
SEPT5	5413	broad.mit.edu	37	chr22	19709395	19709395	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgcgcaacatgctcatcCgcacgcatatgcacgacctc	10	7	8	16	4	1	0	1	0	0	0	3	1	2	0	2	0	5	6	2	0	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:19709395C>T	uc002zpv.1	+	10	990	c.865C>T	c.(865-867)CGC>TGC	p.R289C	SEPT5_uc002zpw.1_RNA|SEPT5_uc002zpx.1_RNA|SEPT5_uc002zpy.1_5'UTR|SEPT5_uc002zpz.1_5'Flank	NM_002688	NP_002679	Q99719	SEPT5_HUMAN	septin 5	289					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)	1	Colorectal(54;0.0993)					CATGCTCATCCGCACGCATAT	0.652													8	44					0	0	0	0	T	19709395	T	T	19709395	3	4	276	1	0	0	0	0	1	0	0	0	14132	652	23	1	903	1	SEPT5	22	19709395	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	264988	19709395	31595171	2027	51916											
TXNRD2	10587	broad.mit.edu	37	chr22	19865925	19865925	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgcatctcgtccagccacCgtgaactccagtggtttata	9	11	9	12	2	1	1	0	1	1	0	4	2	3	1	4	1	3	2	4	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:19865925C>T	uc011ahc.1	-	15	1344	c.1311G>A	c.(1309-1311)ACG>ACA	p.T437T	TXNRD2_uc002zql.1_Silent_p.T191T|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Silent_p.T436T|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_Silent_p.T87T	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	437					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					GTCCAGCCACCGTGAACTCCA	0.567													25	140					0	0	0	0	T	19865925	T	T	19865925	2	4	276	1	0	0	0	0	0	0	0	1	16876	639	23	1		1	TXNRD2	22	19865925	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	156530	19865925	31438641	2028	51917											
SLC7A4	6545	broad.mit.edu	37	chr22	21385614	21385614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccgggtagtggcccaggaggGgcacctgccaagaacccacg	9	3	15	14	2	0	1	0	0	0	1	0	2	0	2	5	5	2	2	5	5	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:21385614G>A	uc002zud.2	-	2	556	c.488C>T	c.(487-489)CCC>CTC	p.P163L	SLC7A4_uc002zue.2_Missense_Mutation_p.P163L	NM_004173	NP_004164	O43246	CTR4_HUMAN	solute carrier family 7 (cationic amino acid	163				THVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSS -> DPRGFLAGAPPGPLPGLPGCWHHPPWPLPLSPVEPACPP (in Ref. 1; CAA04263).	cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			ovary(1)|lung(1)	2	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GCCCAGGAGGGGCACCTGCCA	0.642													6	18					0	0	0	0	A	21385614	A	A	21385614	3	1	276	1	0	0	0	0	1	0	0	0	14763	1232	43	4	1435	4	SLC7A4	22	21385614	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1519689	21385614	29918952	2029	51918											
HIC2	23119	broad.mit.edu	37	chr22	21799757	21799757	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcccacgccccccaggagctCccccaagccaaaggctcaga	10	2	9	20	1	1	1	1	0	0	1	2	2	2	2	7	2	2	2	7	2	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:21799757C>T	uc002zur.3	+	3	803	c.573C>T	c.(571-573)CTC>CTT	p.L191L	HIC2_uc002zus.3_Silent_p.L191L	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	191					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				CCCAGGAGCTCCCCCAAGCCA	0.677													5	17					0	0	0	0	T	21799757	T	T	21799757	2	4	276	1	0	0	0	0	0	0	0	1	7141	842	30	2		2	HIC2	22	21799757	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	414143	21799757	29504809	2030	51919											
PPM1F	9647	broad.mit.edu	37	chr22	22277594	22277594	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agctcttgggggtccctgagGaagaccaccatgaccgtgat	9	8	13	11	1	1	4	0	3	1	1	2	5	2	5	4	3	1	1	4	3	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:22277594G>A	uc002zvp.1	-	8	1350	c.1236C>T	c.(1234-1236)TTC>TTT	p.F412F	PPM1F_uc011aik.1_Silent_p.F308F	NM_014634	NP_055449	P49593	PPM1F_HUMAN	protein phosphatase 1F	412					apoptosis|protein dephosphorylation	protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(2)|large_intestine(1)|breast(1)|kidney(1)	5	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.155)		GGTCCCTGAGGAAGACCACCA	0.687													39	60					0	0	0	0	A	22277594	A	A	22277594	2	1	276	1	0	0	0	0	0	0	0	1	12399	1165	41	2		2	PPM1F	22	22277594	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	477837	22277594	29026972	2031	51920											
GNAZ	2781	broad.mit.edu	37	chr22	23438266	23438266	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgagctgctgggtgtcatGcgacggctctgggccgaccc	4	7	15	15	4	2	0	1	0	1	0	2	3	2	0	3	3	3	3	3	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:23438266G>A	uc002zwu.1	+	2	921	c.384G>A	c.(382-384)ATG>ATA	p.M128I	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	128						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		TGGGTGTCATGCGACGGCTCT	0.672													12	48					0	0	0	0	A	23438266	A	A	23438266	3	1	276	1	0	0	0	0	1	0	0	0	6551	1319	46	4	386	4	GNAZ	22	23438266	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1160672	23438266	27866300	2032	51921											
RGL4	266747	broad.mit.edu	37	chr22	24038805	24038805	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgctgacacctggcaggcggGgagctttaaggtggccaccc	7	6	15	13	2	0	1	0	1	0	0	0	2	0	2	3	6	1	3	3	6	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:24038805G>A	uc002zxn.2	+	7	2261	c.1091G>A	c.(1090-1092)GGG>GAG	p.G364E	LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Missense_Mutation_p.G364E|RGL4_uc002zxp.1_Missense_Mutation_p.G228E|RGL4_uc002zxq.2_Missense_Mutation_p.G228E	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	364	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						TGGCAGGCGGGGAGCTTTAAG	0.657													3	31					0	0	0	0	A	24038805	A	A	24038805	3	1	276	1	0	0	0	0	1	0	0	0	13344	1232	43	4	1117	4	RGL4	22	24038805	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	600539	24038805	27265761	2033	51922											
CABIN1	23523	broad.mit.edu	37	chr22	24573698	24573698	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctccgccgccaccaagttCccccctgagatcaccgtcac	7	6	6	22	3	2	1	2	1	0	1	4	2	4	1	9	0	0	1	9	0	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:24573698C>T	uc002zzi.1	+	36	6559	c.6432C>T	c.(6430-6432)TTC>TTT	p.F2144F	CABIN1_uc002zzj.1_Silent_p.F2065F|CABIN1_uc002zzl.1_Silent_p.F2144F|CABIN1_uc010gul.1_Silent_p.F82F	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	2144	Required for interaction with calcineurin (By similarity).				cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CCACCAAGTTCCCCCCTGAGA	0.657													14	23					0	0	0	0	T	24573698	T	T	24573698	2	4	276	1	0	0	0	0	0	0	0	1	2540	854	30	2		2	CABIN1	22	24573698	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	534893	24573698	26730868	2034	51923											
ASPHD2	57168	broad.mit.edu	37	chr22	26830270	26830270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccagcggggagtggttcaCcttttacttggtcaatcagg	7	11	12	11	1	3	0	3	0	0	0	3	1	3	1	3	5	2	1	3	5	2	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:26830270C>T	uc003acg.2	+	2	1086	c.689C>T	c.(688-690)ACC>ATC	p.T230I		NM_020437	NP_065170	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	230	Lumenal (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			ovary(1)	1						GAGTGGTTCACCTTTTACTTG	0.537													13	68					0	0	0	0	T	26830270	T	T	26830270	3	4	276	1	0	0	0	0	1	0	0	0	1057	507	18	4	691	4	ASPHD2	22	26830270	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2256572	26830270	24474296	2035	51924											
CHEK2	11200	broad.mit.edu	37	chr22	29083922	29083922	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acacagctgggcgctttgtgGtctcggcaccctcggcttcc	4	10	12	15	3	1	0	0	0	1	0	4	0	2	0	2	4	1	4	2	4	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:29083922G>A	uc003adu.1	-	15	1667	c.1595C>T	c.(1594-1596)ACC>ATC	p.T532I	CHEK2_uc003ads.1_Missense_Mutation_p.T311I|CHEK2_uc010gvh.1_Missense_Mutation_p.T441I|CHEK2_uc010gvi.1_Missense_Mutation_p.T381I|CHEK2_uc010gvj.1_RNA|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.T575I|CHEK2_uc003adv.1_Missense_Mutation_p.T503I|CHEK2_uc003adw.1_Missense_Mutation_p.T532I|CHEK2_uc003adx.1_Missense_Mutation_p.T311I|CHEK2_uc003ady.1_Missense_Mutation_p.T521I|CHEK2_uc003adz.1_Missense_Mutation_p.T336I	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	532					cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						GCGCTTTGTGGTCTCGGCACC	0.468			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				9	33					0	0	0	0	A	29083922	A	A	29083922	3	1	276	1	0	0	0	0	1	0	0	0	3350	1261	44	4	40	4	CHEK2	22	29083922	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2253652	29083922	22220644	2036	51925											
NEFH	4744	broad.mit.edu	37	chr22	29885337	29885337	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggccaagtccccagagaagGaggaagcaaaatctccagct	15	4	11	11	0	1	1	0	0	1	1	3	4	2	3	4	3	2	2	4	3	5	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:29885337G>A	uc003afo.2	+	4	1779	c.1708G>A	c.(1708-1710)GAG>AAG	p.E570K	NEFH_uc003afp.2_Intron	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	570	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament					0						CCCAGAGAAGGAGGAAGCAAA	0.567													8	66					0	0	0	0	A	29885337	A	A	29885337	3	1	276	1	0	0	0	0	1	0	0	0	10368	1175	41	2	1722	2	NEFH	22	29885337	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	801415	29885337	21419229	2037	51926											
THOC5	8563	broad.mit.edu	37	chr22	29927884	29927884	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggggaggcggcaggtgtctGgctgtctcatactgcttgtg	5	11	17	8	1	2	0	1	0	2	0	3	1	2	1	0	6	2	3	0	6	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:29927884G>A	uc003afr.2	-	9	1118	c.783C>T	c.(781-783)GCC>GCT	p.A261A	THOC5_uc003afs.2_Silent_p.A261A|THOC5_uc003aft.2_Silent_p.A261A|THOC5_uc003afu.2_Silent_p.A261A|THOC5_uc010gvo.2_Missense_Mutation_p.P4L|THOC5_uc003afv.1_Silent_p.A261A	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	261					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						GCAGGTGTCTGGCTGTCTCAT	0.557													13	29					0	0	0	0	A	29927884	A	A	29927884	2	1	276	1	0	0	0	0	0	0	0	1	15934	1335	47	4		4	THOC5	22	29927884	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	42547	29927884	21376682	2038	51927											
OSM	5008	broad.mit.edu	37	chr22	30660007	30660007	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctccccccacttgctgaaGacccgccccactgagtgcat	7	8	7	19	1	1	3	0	2	1	1	2	3	1	3	6	0	2	2	6	0	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:30660007G>A	uc003ahb.2	-	3	676	c.624C>T	c.(622-624)GTC>GTT	p.V208V		NM_020530	NP_065391	P13725	ONCM_HUMAN	oncostatin M precursor	208					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			skin(1)	1			Epithelial(10;0.206)			ACTTGCTGAAGACCCGCCCCA	0.667													12	50					0	0	0	0	A	30660007	A	A	30660007	2	1	276	1	0	0	0	0	0	0	0	1	11345	929	33	2		2	OSM	22	30660007	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	732123	30660007	20644559	2039	51928											
SEC14L2	23541	broad.mit.edu	37	chr22	30818340	30818340	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcactgtggaggtcctgcttCcagacaaagcctcagaagag	11	8	11	11	0	2	3	2	0	0	3	4	4	4	4	3	2	2	1	3	2	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:30818340C>T	uc003ahr.2	+	12	1329	c.1156C>T	c.(1156-1158)CCA>TCA	p.P386S	SEC14L2_uc011akx.1_Missense_Mutation_p.P332S|SEC14L2_uc003ahs.2_Missense_Mutation_p.P312S|SEC14L2_uc011aky.1_Missense_Mutation_p.P303S|SEC14L2_uc003aht.2_RNA|SEC14L2_uc003ahu.3_Intron|SEC14L2_uc010gvv.2_RNA|SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Intron|MTP18_uc003ahv.1_Intron|MTP18_uc010gvy.1_Intron	NM_012429	NP_036561	O76054	S14L2_HUMAN	SEC14-like 2 isoform 1	386					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	phospholipid binding|transporter activity|vitamin E binding				0					Vitamin E(DB00163)	GGTCCTGCTTCCAGACAAAGC	0.527													19	65					0	0	0	0	T	30818340	T	T	30818340	3	4	276	1	0	0	0	0	1	0	0	0	14047	855	30	2	1300	2	SEC14L2	22	30818340	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	158333	30818340	20486226	2040	51929											
MORC2	22880	broad.mit.edu	37	chr22	31328351	31328351	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcaggccagactcaccagagGaaaagatattagctcatctg	14	8	9	10	0	4	3	3	0	1	3	4	4	4	4	2	2	1	1	2	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:31328351G>A	uc003aje.1	-	25	4014	c.2650C>T	c.(2650-2652)CCT>TCT	p.P884S		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	946							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						CTCACCAGAGGAAAAGATATT	0.463													22	70					0	0	0	0	A	31328351	A	A	31328351	3	1	276	1	0	0	0	0	1	0	0	0	9755	1174	41	2	274	2	MORC2	22	31328351	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	510011	31328351	19976215	2041	51930											
INPP5J	27124	broad.mit.edu	37	chr22	31522645	31522645	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaagcgactcaaggacgccCtcttcacggaccagtggagt	11	6	11	13	3	3	0	2	0	1	0	3	4	3	3	2	3	1	0	2	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:31522645C>T	uc003aju.3	+	4	1524	c.1432C>T	c.(1432-1434)CTC>TTC	p.L478F	INPP5J_uc010gwf.2_Missense_Mutation_p.L478F|INPP5J_uc003ajv.3_Missense_Mutation_p.L111F|INPP5J_uc003ajs.3_Missense_Mutation_p.L111F|INPP5J_uc011alk.1_Missense_Mutation_p.L411F|INPP5J_uc010gwg.2_Missense_Mutation_p.L43F|INPP5J_uc003ajw.2_5'UTR|INPP5J_uc003ajt.3_Missense_Mutation_p.L110F|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	478	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						CAAGGACGCCCTCTTCACGGA	0.617													39	150					0	0	0	0	T	31522645	T	T	31522645	3	4	276	1	0	0	0	0	1	0	0	0	7798	681	24	4	342	4	INPP5J	22	31522645	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	194294	31522645	19781921	2042	51931											
SFI1	9814	broad.mit.edu	37	chr22	31979928	31979928	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaaggaaagagagctgctccCcttactgcatgctgcctggg	10	8	12	11	0	0	1	0	0	0	1	1	3	1	2	3	2	6	4	3	2	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:31979928C>T	uc003ale.2	+	13	1709	c.1316C>T	c.(1315-1317)CCC>CTC	p.P439L	SFI1_uc003ald.1_Missense_Mutation_p.P415L|SFI1_uc003alf.2_Missense_Mutation_p.P408L|SFI1_uc003alg.2_Missense_Mutation_p.P357L|SFI1_uc011alp.1_Missense_Mutation_p.P357L|SFI1_uc011alq.1_Missense_Mutation_p.P384L|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	439					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						GAGCTGCTCCCCTTACTGCAT	0.512													63	113					0	0	0	0	T	31979928	T	T	31979928	3	4	276	1	0	0	0	0	1	0	0	0	14221	623	22	4	1362	4	SFI1	22	31979928	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	457283	31979928	19324638	2043	51932											
SLC5A1	6523	broad.mit.edu	37	chr22	32480501	32480501	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccaaccatagtgtctgatgGcaacaccacctttcaggaaa	13	9	7	12	0	2	1	1	1	1	0	3	2	3	2	4	2	2	1	4	2	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:32480501G>A	uc003amc.2	+	8	972	c.740G>A	c.(739-741)GGC>GAC	p.G247D	SLC5A1_uc011alz.1_Missense_Mutation_p.G120D	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	247	Extracellular (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						GTGTCTGATGGCAACACCACC	0.502													16	34					0	0	0	0	A	32480501	A	A	32480501	3	1	276	1	0	0	0	0	1	0	0	0	14725	1203	42	4	770	4	SLC5A1	22	32480501	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	500573	32480501	18824065	2044	51933											
ISX	91464	broad.mit.edu	37	chr22	35478537	35478537	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaagagcaagcggagggttCgtaccaccttcaccactgag	11	6	13	11	2	1	2	1	1	0	1	2	4	1	4	3	3	3	3	3	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:35478537C>T	uc003anj.2	+	2	1207	c.256C>T	c.(256-258)CGT>TGT	p.R86C	ISX_uc011amg.1_Missense_Mutation_p.R74C	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	86	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						GCGGAGGGTTCGTACCACCTT	0.557													31	44					0	0	0	0	T	35478537	T	T	35478537	3	4	276	1	0	0	0	0	1	0	0	0	7904	884	31	1	262	1	ISX	22	35478537	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2998036	35478537	15826029	2045	51934											
TOM1	10043	broad.mit.edu	37	chr22	35723363	35723363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacccaggccgagcccgcaGacctggagctgctgcaggtg	7	4	14	16	2	0	1	0	0	0	1	0	3	0	2	5	3	4	4	5	3	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:35723363G>A	uc003ann.2	+	7	873	c.748G>A	c.(748-750)GAC>AAC	p.D250N	TOM1_uc011ami.1_Missense_Mutation_p.D217N|TOM1_uc011amj.1_Missense_Mutation_p.D93N|TOM1_uc003ans.2_Missense_Mutation_p.D93N|TOM1_uc011amk.1_Missense_Mutation_p.D212N|TOM1_uc003anp.2_Missense_Mutation_p.D250N|TOM1_uc011aml.1_Missense_Mutation_p.D205N|TOM1_uc003ano.2_RNA|TOM1_uc003anq.2_Missense_Mutation_p.D244N|TOM1_uc003anr.2_Missense_Mutation_p.D93N	NM_005488	NP_005479	O60784	TOM1_HUMAN	target of myb1 isoform 1	250	GAT.				endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			ovary(1)	1						CGAGCCCGCAGACCTGGAGCT	0.627													4	31					0	0	0	0	A	35723363	A	A	35723363	3	1	276	1	0	0	0	0	1	0	0	0	16417	942	33	2	774	2	TOM1	22	35723363	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	244826	35723363	15581203	2046	51935											
APOL1	8542	broad.mit.edu	37	chr22	36661678	36661678	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgagaacatatccaactttCtttccttagctggcaatact	11	14	6	10	0	1	1	0	1	1	1	3	2	3	1	2	1	4	2	2	1	6	5	rs41311348		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:36661678C>T	uc003apf.2	+	6	964	c.796C>T	c.(796-798)CTT>TTT	p.L266F	APOL1_uc011amn.1_Missense_Mutation_p.L143F|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Missense_Mutation_p.L282F|APOL1_uc011amo.1_Missense_Mutation_p.L143F|APOL1_uc011amp.1_Missense_Mutation_p.L266F|APOL1_uc011amq.1_Missense_Mutation_p.L248F|APOL1_uc010gwx.2_Missense_Mutation_p.L143F	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	266					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						ATCCAACTTTCTTTCCTTAGC	0.507													15	49					0	0	0	0	T	36661678	T	T	36661678	3	4	276	1	0	0	0	0	1	0	0	0	805	913	32	2	866	2	APOL1	22	36661678	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	938315	36661678	14642888	2047	51936											
CSF2RB	1439	broad.mit.edu	37	chr22	37326786	37326786	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caggcaccactgccagattcCcgtgcccgaccccgcgaccc	7	4	9	21	4	0	1	0	0	0	1	1	3	1	1	7	1	2	1	7	1	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:37326786C>T	uc003aqa.3	+	8	1143	c.926C>T	c.(925-927)CCC>CTC	p.P309L	CSF2RB_uc003aqc.3_Missense_Mutation_p.P315L	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	309	Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	TGCCAGATTCCCGTGCCCGAC	0.612													13	28					0	0	0	0	T	37326786	T	T	37326786	3	4	276	1	0	0	0	0	1	0	0	0	3952	623	22	4	952	4	CSF2RB	22	37326786	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	665108	37326786	13977780	2048	51937											
TMPRSS6	164656	broad.mit.edu	37	chr22	37494578	37494578	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacctggctgaccatcacctCcgccttgtaccctgcccagg	6	8	8	19	1	1	1	1	1	0	0	2	1	2	1	7	2	2	2	7	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:37494578C>T	uc003aqs.1	-	3	355	c.241G>A	c.(241-243)GAG>AAG	p.E81K	TMPRSS6_uc003aqt.1_Missense_Mutation_p.E72K|TMPRSS6_uc003aqu.2_Missense_Mutation_p.E72K	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	81	Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						ACCATCACCTCCGCCTTGTAC	0.587													30	124					0	0	0	0	T	37494578	T	T	37494578	3	4	276	1	0	0	0	0	1	0	0	0	16317	864	30	2	2258	2	TMPRSS6	22	37494578	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	167792	37494578	13809988	2049	51938											
IL2RB	3560	broad.mit.edu	37	chr22	37524552	37524553	+	Missense_Mutation	DNP	CC	TT	TT																															ggtgcagtaggcgtcgtcctCccctgacagaggctgcaggg																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:37524552_37524553CC>TT	uc003aqv.1	-	10	1370_1371	c.1239_1240GG>AA	c.(1237-1242)GGGGAG>GGAAAG	p.E414K		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	414	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GCGTCGTCCTCCCCTGACAGAG	0.653													20	24					0	0	0	0	TT	37524553	TT	TT	37524552	3	4	276	1	0	0	0	0	1	0	0	0	7726	864	30	2	419	2	IL2RB	22	37524552	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	29974	37524552	13780014	2050	51939											
ELFN2	114794	broad.mit.edu	37	chr22	37770430	37770430	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcgccaagtctccggggacgGggtcccgcgtggtgaaggtc	5	6	18	12	5	1	1	0	1	1	0	4	2	2	2	3	6	0	0	3	6	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:37770430G>A	uc003asq.3	-	3	1931	c.1145C>T	c.(1144-1146)CCC>CTC	p.P382L		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	382	Extracellular (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					TCCGGGGACGGGGTCCCGCGT	0.637													11	35					0	0	0	0	A	37770430	A	A	37770430	3	1	276	1	0	0	0	0	1	0	0	0	5082	1232	43	4	1321	4	ELFN2	22	37770430	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	245878	37770430	13534136	2051	51940											
CARD10	29775	broad.mit.edu	37	chr22	37892485	37892485	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccatcagggaggggagtgtgGacccctgattccagagcaag	10	6	15	10	0	1	2	1	1	0	1	2	5	2	5	4	4	1	1	4	4	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:37892485G>A	uc003asx.1	-	13	2033	c.2030C>T	c.(2029-2031)TCC>TTC	p.S677F	CARD10_uc003ast.1_RNA|CARD10_uc003asv.1_5'Flank|CARD10_uc011ank.1_5'UTR|CARD10_uc003asw.1_Missense_Mutation_p.S391F|CARD10_uc003asy.1_Missense_Mutation_p.S677F	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	677					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					GGGGAGTGTGGACCCCTGATT	0.637													11	38					0	0	0	0	A	37892485	A	A	37892485	3	1	276	1	0	0	0	0	1	0	0	0	2656	1174	41	2	1100	2	CARD10	22	37892485	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	122055	37892485	13412081	2052	51941											
TRIOBP	11078	broad.mit.edu	37	chr22	38121032	38121033	+	Missense_Mutation	DNP	CC	TT	TT																															acttgtattcaacagaacatCcccagatcatcttctaccca																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:38121032_38121033CC>TT	uc003atr.2	+	7	2740_2741	c.2469_2470CC>TT	c.(2467-2472)ATCCCC>ATTTCC	p.P824S	TRIOBP_uc003atu.2_Missense_Mutation_p.P652S|TRIOBP_uc003atq.1_Missense_Mutation_p.P824S|TRIOBP_uc003ats.1_Missense_Mutation_p.P652S	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	824					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					AACAGAACATCCCCAGATCATC	0.52													18	70					0	0	0	0	TT	38121033	TT	TT	38121032	3	4	276	1	0	0	0	0	1	0	0	0	16620	845	30	2	2487	2	TRIOBP	22	38121032	Missense_Mutation	DNP	CC	TCGA-D6-6516-01A-11D-1870-08	228547	38121032	13183534	2053	51942											
TRIOBP	11078	broad.mit.edu	37	chr22	38121451	38121451	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccagcatgacccaccccagtCctcctttggccccacccagt	7	7	6	21	0	0	1	0	1	0	0	2	1	2	1	9	1	1	1	9	1	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:38121451C>T	uc003atr.2	+	7	3159	c.2888C>T	c.(2887-2889)TCC>TTC	p.S963F	TRIOBP_uc003atu.2_Missense_Mutation_p.S791F|TRIOBP_uc003atq.1_Missense_Mutation_p.S963F|TRIOBP_uc003ats.1_Missense_Mutation_p.S791F	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	963					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCACCCCAGTCCTCCTTTGGC	0.637													53	86					0	0	0	0	T	38121451	T	T	38121451	3	4	276	1	0	0	0	0	1	0	0	0	16620	855	30	2	2906	2	TRIOBP	22	38121451	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	419	38121451	13183115	2054	51943											
TRIOBP	11078	broad.mit.edu	37	chr22	38121538	38121538	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccagagcacctcccgaacttCctcacctgtgtaccccgctg	7	8	7	19	2	1	1	1	0	0	1	3	2	3	1	7	0	3	3	7	0	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:38121538C>T	uc003atr.2	+	7	3246	c.2975C>T	c.(2974-2976)TCC>TTC	p.S992F	TRIOBP_uc003atu.2_Missense_Mutation_p.S820F|TRIOBP_uc003atq.1_Missense_Mutation_p.S992F|TRIOBP_uc003ats.1_Missense_Mutation_p.S820F	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	992					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TCCCGAACTTCCTCACCTGTG	0.647													23	119					0	0	0	0	T	38121538	T	T	38121538	3	4	276	1	0	0	0	0	1	0	0	0	16620	855	30	2	2993	2	TRIOBP	22	38121538	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	87	38121538	13183028	2055	51944											
TRIOBP	11078	broad.mit.edu	37	chr22	38130789	38130789	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcatgggggggcacttccagGgagtacaaggagagctgggg	9	5	20	7	0	0	1	0	0	0	1	1	3	1	2	1	7	2	4	1	7	2	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:38130789G>A	uc003atr.2	+	9	4717	c.4446G>A	c.(4444-4446)AGG>AGA	p.R1482R	TRIOBP_uc003atu.2_Silent_p.R1310R	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	1482					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GCACTTCCAGGGAGTACAAGG	0.682													4	18					0	0	0	0	A	38130789	A	A	38130789	2	1	276	1	0	0	0	0	0	0	0	1	16620	1223	43	4		4	TRIOBP	22	38130789	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	9251	38130789	13173777	2056	51945											
MICALL1	85377	broad.mit.edu	37	chr22	38318042	38318042	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgggcctgaggagggcacCtttgtgtgtgcagaacactg	9	9	15	8	0	0	2	0	1	0	1	0	3	0	3	2	3	2	2	2	3	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:38318042C>A	uc003aui.2	+	6	717	c.633C>A	c.(631-633)ACC>ACA	p.T211T		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	211	LIM zinc-binding.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					AGGAGGGCACCTTTGTGTGTG	0.657													32	40					4.3181e-19	4.48065e-19	1	0	A	38318042	A	A	38318042	2	1	276	1	0	0	0	0	0	0	0	1	9626	668	24	4		4	MICALL1	22	38318042	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	187253	38318042	12986524	2057	51946											
CBX7	23492	broad.mit.edu	37	chr22	39529949	39529949	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcagctgcctgggcctcgcGgaaggtgacggtgatggagt	6	8	17	10	3	1	2	1	2	0	0	2	4	1	4	2	5	2	1	2	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:39529949G>A	uc003axb.2	-	6	792	c.703C>T	c.(703-705)CGC>TGC	p.R235C	CBX7_uc003axc.2_Missense_Mutation_p.R142C	NM_175709	NP_783640	O95931	CBX7_HUMAN	chromobox homolog 7	235	Required for cellular lifespan extension.				chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				ovary(1)	1	Melanoma(58;0.04)					TGGGCCTCGCGGAAGGTGACG	0.597													27	73					0	0	0	0	A	39529949	A	A	39529949	3	1	276	1	0	0	0	0	1	0	0	0	2735	1116	39	1	56	1	CBX7	22	39529949	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1211907	39529949	11774617	2058	51947											
CACNA1I	8911	broad.mit.edu	37	chr22	40057260	40057260	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catgctggtggccctgggctCccgaaagagcagtgtcatgt	7	9	14	11	1	1	1	1	0	0	1	2	2	2	1	2	3	2	3	2	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:40057260C>T	uc003ayc.2	+	16	2846	c.2846C>T	c.(2845-2847)TCC>TTC	p.S949F	CACNA1I_uc003ayd.2_Missense_Mutation_p.S914F|CACNA1I_uc003aye.2_Missense_Mutation_p.S864F|CACNA1I_uc003ayf.2_Missense_Mutation_p.S829F	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	949	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GCCCTGGGCTCCCGAAAGAGC	0.667													18	18					0	0	0	0	T	40057260	T	T	40057260	3	4	276	1	0	0	0	0	1	0	0	0	2558	855	30	2	2908	2	CACNA1I	22	40057260	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	527311	40057260	11247306	2059	51948											
ADSL	158	broad.mit.edu	37	chr22	40754970	40754970	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtccgagatgacctgcgcttCcggggagtaaagggtaccac	9	7	14	11	3	0	2	0	1	0	1	2	4	2	3	4	3	2	3	4	3	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:40754970C>T	uc003ayp.3	+	5	644	c.585C>T	c.(583-585)TTC>TTT	p.F195F	ADSL_uc003ays.3_Silent_p.F195F|ADSL_uc003ayq.3_Silent_p.F195F|ADSL_uc003ayr.3_5'UTR|ADSL_uc003ayt.3_Silent_p.F180F|ADSL_uc010gyb.1_RNA	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	195					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1						ACCTGCGCTTCCGGGGAGTAA	0.517													20	58					0	0	0	0	T	40754970	T	T	40754970	2	4	276	1	0	0	0	0	0	0	0	1	346	854	30	2		2	ADSL	22	40754970	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	697710	40754970	10549596	2060	51949											
SGSM3	27352	broad.mit.edu	37	chr22	40804825	40804825	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaagatggcaaagtcctgacCccggaggagctgctctaccg	10	6	13	12	2	1	2	0	1	1	1	2	5	2	4	4	3	3	3	4	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:40804825C>T	uc003ayu.1	+	18	2090	c.1881C>T	c.(1879-1881)ACC>ACT	p.T627T	SGSM3_uc011aos.1_Silent_p.T560T|SGSM3_uc011aot.1_Silent_p.T538T|SGSM3_uc010gyd.1_Silent_p.T698T	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	627	RUN.				cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						AAGTCCTGACCCCGGAGGAGC	0.657													10	56					0	0	0	0	T	40804825	T	T	40804825	2	4	276	1	0	0	0	0	0	0	0	1	14289	610	22	4		4	SGSM3	22	40804825	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	49855	40804825	10499741	2061	51950											
EP300	2033	broad.mit.edu	37	chr22	41547937	41547937	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cattgctgagaagcagccttCccaggaagtgaagatggagg	12	7	14	8	0	0	3	0	2	0	2	1	6	1	5	2	3	3	2	2	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:41547937C>T	uc003azl.3	+	15	3313	c.2918C>T	c.(2917-2919)TCC>TTC	p.S973F		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	973					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AAGCAGCCTTCCCAGGAAGTG	0.483			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				27	121					0	0	0	0	T	41547937	T	T	41547937	3	4	276	1	0	0	0	0	1	0	0	0	5172	855	30	2	2976	2	EP300	22	41547937	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	743112	41547937	9756629	2062	51951											
TOB2	10766	broad.mit.edu	37	chr22	41833301	41833301	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcgccggggcagcttgttgtAcaagtaggagatgatgaagt	10	9	16	6	2	0	3	0	2	0	1	0	4	0	3	1	3	2	5	1	3	4	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:41833301A>T	uc003azz.1	-	2	756	c.49T>A	c.(49-51)TAC>AAC	p.Y17N		NM_016272	NP_057356	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	17					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				ovary(1)	1						AGCTTGTTGTACAAGTAGGAG	0.537													16	78					0	0	0	0	T	41833301	T	T	41833301	3	4	276	1	0	0	0	0	1	0	0	0	16414	391	14	5	989	5	TOB2	22	41833301	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	285364	41833301	9471265	2063	51952											
XRCC6	2547	broad.mit.edu	37	chr22	42046861	42046861	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	caccattacctgaggccctcCctgttcgtgtacccagagga	8	9	9	15	1	0	2	0	1	0	1	2	3	1	3	5	2	2	2	5	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:42046861C>T	uc003bao.1	+	8	1165	c.1095C>T	c.(1093-1095)TCC>TCT	p.S365S	XRCC6_uc003bap.1_Silent_p.S324S|XRCC6_uc011apc.1_Silent_p.S315S|XRCC6_uc003baq.1_Silent_p.S365S|XRCC6_uc003bar.1_Silent_p.S365S|XRCC6_uc003bas.1_Silent_p.S315S	NM_001469	NP_001460	P12956	XRCC6_HUMAN	ATP-dependent DNA helicase II, 70 kDa subunit	365	Ku.				DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			skin(2)|ovary(1)|lung(1)|kidney(1)	5						TGAGGCCCTCCCTGTTCGTGT	0.498								Direct_reversal_of_damage|NHEJ					6	43					0	0	0	0	T	42046861	T	T	42046861	2	4	276	1	0	0	0	0	0	0	0	1	17525	610	22	4		4	XRCC6	22	42046861	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	213560	42046861	9257705	2064	51953											
PACSIN2	11252	broad.mit.edu	37	chr22	43275168	43275168	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gggttcgattcaggtctgcgGaccactcctaggcaacaggt	8	9	13	11	2	2	0	1	0	1	0	4	2	3	1	2	5	2	2	2	5	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:43275168G>A	uc010gzg.2	-	8	1136	c.914C>T	c.(913-915)TCC>TTC	p.S305F	PACSIN2_uc003bdg.3_Missense_Mutation_p.S305F|PACSIN2_uc003bde.3_Missense_Mutation_p.S305F|PACSIN2_uc003bdf.3_Missense_Mutation_p.S305F	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	305					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				CAGGTCTGCGGACCACTCCTA	0.597													13	34					0	0	0	0	A	43275168	A	A	43275168	3	1	276	1	0	0	0	0	1	0	0	0	11429	1174	41	2	562	2	PACSIN2	22	43275168	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1228307	43275168	8029398	2065	51954											
SAMM50	25813	broad.mit.edu	37	chr22	44368775	44368775	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggcctcaagcttcctaatCttcttggtcgtgcagaaaag	9	13	9	10	1	3	1	1	0	2	1	5	1	4	1	2	2	2	2	2	2	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:44368775C>T	uc003bej.2	+	6	651	c.454C>T	c.(454-456)CTT>TTT	p.L152F	SAMM50_uc011aqd.1_Intron|SAMM50_uc003bek.2_5'Flank	NM_015380	NP_056195	Q9Y512	SAM50_HUMAN	sorting and assembly machinery component 50	152					protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial sorting and assembly machinery complex	protein binding			skin(1)	1		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				GCTTCCTAATCTTCTTGGTCG	0.428													38	118					0	0	0	0	T	44368775	T	T	44368775	3	4	276	1	0	0	0	0	1	0	0	0	13894	913	32	2	476	2	SAMM50	22	44368775	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1093607	44368775	6935791	2066	51955											
PARVG	64098	broad.mit.edu	37	chr22	44585099	44585099	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgtgaaccggagtctgcAgctggaggagtggcaggcca	8	5	18	10	2	1	1	0	1	1	0	1	4	1	4	3	6	3	3	3	6	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:44585099A>C	uc011aqe.1	+	6	777	c.353A>C	c.(352-354)CAG>CCG	p.Q118P	PARVG_uc003bep.2_Missense_Mutation_p.Q118P|PARVG_uc011aqf.1_Missense_Mutation_p.Q118P|PARVG_uc003beq.2_RNA|PARVG_uc003ber.2_RNA	NM_001137605	NP_001131077	Q9HBI0	PARVG_HUMAN	parvin, gamma	118	CH 1.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding				0		Ovarian(80;0.024)|all_neural(38;0.0299)				CGGAGTCTGCAGCTGGAGGAG	0.647													12	26					0	0	0	0	C	44585099	C	C	44585099	3	2	276	1	0	0	0	0	1	0	0	0	11524	188	7	5	367	5	PARVG	22	44585099	Missense_Mutation	SNP	A	TCGA-D6-6516-01A-11D-1870-08	216324	44585099	6719467	2067	51956											
PHF21B	112885	broad.mit.edu	37	chr22	45316339	45316340	+	Missense_Mutation	DNP	GT	AA	AA																															aggagctgacctgaggacccGtgacaggcactgcagtgatc																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:45316339_45316340GT>AA	uc003bfn.2	-	3	302_303	c.151_152AC>TT	c.(151-153)ACG>TTG	p.T51L	PHF21B_uc003bfm.2_5'UTR|PHF21B_uc011aqk.1_Missense_Mutation_p.T39L|PHF21B_uc011aql.1_Missense_Mutation_p.T51L|PHF21B_uc011aqm.1_Missense_Mutation_p.T39L	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	51							zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		CTGAGGACCCGTGACAGGCACT	0.634													4	11					0	0	0	0	AA	45316340	AA	AA	45316339	3	1	276	1	0	0	0	0	1	0	0	0	11889	1145	40	1	1487	1	PHF21B	22	45316339	Missense_Mutation	DNP	GT	TCGA-D6-6516-01A-11D-1870-08	731240	45316339	5988227	2068	51957											
SMC1B	27127	broad.mit.edu	37	chr22	45765889	45765889	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgttctcaaattcacgaaTattttccacgccaatttctt	10	18	3	10	2	3	0	2	0	2	0	5	1	4	0	2	0	0	1	2	0	4	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:45765889T>C	uc003bgc.2	-	15	2417	c.2365A>G	c.(2365-2367)ATT>GTT	p.I789V	SMC1B_uc003bgd.2_Missense_Mutation_p.I789V|SMC1B_uc003bge.1_Missense_Mutation_p.I572V	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	789	Potential.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		AATTCACGAATATTTTCCACG	0.239													19	22					0	0	0	0	C	45765889	C	C	45765889	3	2	276	1	0	0	0	0	1	0	0	0	14846	1406	49	5	1386	5	SMC1B	22	45765889	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	449550	45765889	5538677	2069	51958											
PKDREJ	10343	broad.mit.edu	37	chr22	46654239	46654239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tggatgcatacgcattccatCcaacctgatctcagtatatt	11	13	6	11	1	1	1	1	1	1	0	4	2	3	2	3	1	3	3	3	1	4	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:46654239C>T	uc003bhh.2	-	1	4981	c.4981G>A	c.(4981-4983)GAT>AAT	p.D1661N		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1661	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CGCATTCCATCCAACCTGATC	0.413													17	48					0	0	0	0	T	46654239	T	T	46654239	3	4	276	1	0	0	0	0	1	0	0	0	12025	855	30	2	1784	2	PKDREJ	22	46654239	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	888350	46654239	4650327	2070	51959											
CRELD2	79174	broad.mit.edu	37	chr22	50315256	50315256	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccagggcggatcccagaggCcctgcagcgggaatggccac	8	3	16	14	2	0	1	0	0	0	1	1	3	1	3	4	5	2	1	4	5	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:50315256C>T	uc003bja.2	+	5	574	c.439C>T	c.(439-441)CCC>TCC	p.P147S	CRELD2_uc003biz.3_Missense_Mutation_p.P147S|CRELD2_uc010haj.2_Missense_Mutation_p.P147S|CRELD2_uc010hal.2_Missense_Mutation_p.P147S|CRELD2_uc010hak.2_Missense_Mutation_p.P147S|CRELD2_uc010ham.2_Missense_Mutation_p.P147S	NM_024324	NP_077300	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2 isoform b	147	EGF-like 1.					endoplasmic reticulum|extracellular region	calcium ion binding				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		ATCCCAGAGGCCCTGCAGCGG	0.642													8	26					0	0	0	0	T	50315256	T	T	50315256	3	4	276	1	0	0	0	0	1	0	0	0	3882	739	26	4	457	4	CRELD2	22	50315256	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3661017	50315256	989310	2071	51960											
RABL2B	11158	broad.mit.edu	37	chr22	51207916	51207916	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtaccatcagcagccgagacGaaatacaggggcagggagaa	15	3	14	9	2	1	2	1	0	0	2	1	5	1	2	2	3	4	3	2	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chr22:51207916G>A	uc003bno.1	-	7	687	c.471C>T	c.(469-471)TTC>TTT	p.F157F	RPL23AP82_uc011asd.1_Intron|RPL23AP82_uc003bni.2_Intron|RABL2B_uc011ase.1_RNA|RABL2B_uc003bnm.1_Silent_p.F157F|RABL2B_uc011asf.1_Silent_p.F158F|RABL2B_uc003bnn.1_Silent_p.F158F|RABL2B_uc003bnk.1_Silent_p.F158F|RABL2B_uc011asg.1_Silent_p.F158F|RABL2B_uc003bnl.1_Silent_p.F157F|RABL2B_uc011ash.1_RNA	NM_001130922	NP_001124394	Q9UNT1	RBL2B_HUMAN	RAB, member of RAS oncogene family-like 2B	157					small GTPase mediated signal transduction		GTP binding|GTPase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.0539)|LUAD - Lung adenocarcinoma(64;0.247)		CAGCCGAGACGAAATACAGGG	0.493													29	83					0	0	0	0	A	51207916	A	A	51207916	2	1	276	1	0	0	0	0	0	0	0	1	13036	1049	37	1		1	RABL2B	22	51207916	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	892660	51207916	96650	2072	51961											
CRLF2	64109	broad.mit.edu	37	chrX	1314914	1314914	+	RNA	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccataatttccataaagaCagaaggaggagagacaccat	17	7	8	9	0	0	3	0	0	0	3	2	6	2	5	3	2	0	0	3	2	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:1314914C>G	uc004cpm.1	-	6		c.929G>C						Q9HC73	CRLF2_HUMAN	Homo sapiens mRNA for IL-XR, complete cds.							extracellular region|integral to membrane|plasma membrane	receptor activity			haematopoietic_and_lymphoid_tissue(7)	7		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TCCATAAAGACAGAAGGAGGA	0.483			Mis|T	P2RY8|IGH@	B-ALL|Downs associated ALL								8	29					0	0	0	0	G	1314914	G	G	1314914	1	3	276	0	1	0	0	0	0	0	0	0	3902	465	17	4		4	CRLF2	23	1314914	RNA	SNP	C	TCGA-D6-6516-01A-11D-1870-08		1314914	153955646	2073	51962											
ASMT	438	broad.mit.edu	37	chrX	1742148	1742148	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agcgcccatgggacagagctCctgctggacatctgtgtgtc	7	9	13	12	1	1	1	0	0	1	1	3	3	2	3	2	2	3	2	2	2	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:1742148C>T	uc004cqd.2	+	3	331	c.186C>T	c.(184-186)CTC>CTT	p.L62L	ASMT_uc010ncy.2_Silent_p.L62L|ASMT_uc004cqe.2_Silent_p.L62L	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	62					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGACAGAGCTCCTGCTGGACA	0.617													7	85					0	0	0	0	T	1742148	T	T	1742148	2	4	276	1	0	0	0	0	0	0	0	1	1047	842	30	2		2	ASMT	23	1742148	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	427234	1742148	153528412	2074	51963											
ASMT	438	broad.mit.edu	37	chrX	1743190	1743190	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgaaacacagagctgtccagCgactacctgaccacggtcag	12	5	10	14	3	1	2	1	1	0	1	2	4	2	2	3	1	4	1	3	1	2	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:1743190C>T	uc004cqd.2	+	4	418	c.273C>T	c.(271-273)AGC>AGT	p.S91S	ASMT_uc010ncy.2_Silent_p.S91S|ASMT_uc004cqe.2_Silent_p.S91S	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	91					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGCTGTCCAGCGACTACCTGA	0.572													31	369					0	0	0	0	T	1743190	T	T	1743190	2	4	276	1	0	0	0	0	0	0	0	1	1047	767	27	1		1	ASMT	23	1743190	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1042	1743190	153527370	2075	51964											
MXRA5	25878	broad.mit.edu	37	chrX	3239247	3239247	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agaattgtggatggggacgaGgatgctggctccttcatccg	8	10	15	8	2	1	1	1	0	0	1	3	5	3	4	2	5	1	2	2	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:3239247G>A	uc004crg.3	-	5	4636	c.4479C>T	c.(4477-4479)TCC>TCT	p.S1493S		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1493						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ATGGGGACGAGGATGCTGGCT	0.483													24	40					0	0	0	0	A	3239247	A	A	3239247	2	1	276	1	0	0	0	0	0	0	0	1	10056	987	35	4		4	MXRA5	23	3239247	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1496057	3239247	152031313	2076	51965											
CLCN4	1183	broad.mit.edu	37	chrX	10163010	10163010	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgacggacctgaaggaggggGtctgcctgtctgccttctgg	5	10	16	10	1	3	2	0	2	3	0	3	4	3	4	3	5	2	0	3	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:10163010G>T	uc004csy.3	+	5	734	c.304G>T	c.(304-306)GTC>TTC	p.V102F	CLCN4_uc011mid.1_Missense_Mutation_p.V8F	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	102	Helical; (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GAAGGAGGGGGTCTGCCTGTC	0.552													66	29					6.8682e-38	7.1678e-38	1	0	T	10163010	T	T	10163010	3	4	276	1	0	0	0	0	1	0	0	0	3480	1261	44	4	314	4	CLCN4	23	10163010	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	6923763	10163010	145107550	2077	51966											
ARHGAP6	395	broad.mit.edu	37	chrX	11682604	11682604	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagtcaaagtgaaagctgccGgatggtgacttctcctgcgg	9	10	13	9	2	2	2	1	2	1	0	3	3	2	3	2	3	3	1	2	3	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:11682604G>A	uc004cup.1	-	1	1218	c.345C>T	c.(343-345)TCC>TCT	p.S115S	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Silent_p.S115S	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	115					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						GAAAGCTGCCGGATGGTGACT	0.657													13	5					0	0	0	0	A	11682604	A	A	11682604	2	1	276	1	0	0	0	0	0	0	0	1	887	1103	39	1		1	ARHGAP6	23	11682604	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1519594	11682604	143587956	2078	51967											
KLHL34	257240	broad.mit.edu	37	chrX	21675148	21675148	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgtggtagttgagggcctgGatgatgaggcccttgacccg	6	10	17	8	1	0	4	0	4	0	0	0	5	0	5	3	4	0	2	3	4	1	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:21675148G>A	uc004czz.1	-	1	1301	c.759C>T	c.(757-759)ATC>ATT	p.I253I		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	253										ovary(1)	1						TGAGGGCCTGGATGATGAGGC	0.692													8	6					0	0	0	0	A	21675148	A	A	21675148	2	1	276	1	0	0	0	0	0	0	0	1	8426	1164	41	2		2	KLHL34	23	21675148	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	9992544	21675148	133595412	2079	51968											
CXorf58	254158	broad.mit.edu	37	chrX	23933835	23933835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggaattctatgtaacacatGaaatactgaagaaagtggcc	17	9	9	6	0	1	3	0	2	1	1	1	4	1	4	1	2	2	1	1	2	7	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:23933835G>A	uc004daz.1	+	4	579	c.235G>A	c.(235-237)GAA>AAA	p.E79K	CXorf58_uc011mju.1_Missense_Mutation_p.E79K	NM_152761	NP_689974	Q96LI9	CX058_HUMAN	hypothetical protein LOC254158	79											0						TGTAACACATGAAATACTGAA	0.338													11	14					0	0	0	0	A	23933835	A	A	23933835	3	1	276	1	0	0	0	0	1	0	0	0	4131	1291	45	2	245	2	CXorf58	23	23933835	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2258687	23933835	131336725	2080	51969											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29301114	29301114	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atcaagttttggtgggagagCctgttcgaatcaaatgtgca	11	12	12	6	1	2	1	2	0	0	1	3	3	2	1	1	2	2	3	1	2	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:29301114C>T	uc004dby.2	+	3	650	c.142C>T	c.(142-144)CCT>TCT	p.P48S		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	48	Ig-like C2-type 1.|Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						GGTGGGAGAGCCTGTTCGAAT	0.398													22	18					0	0	0	0	T	29301114	T	T	29301114	3	4	276	1	0	0	0	0	1	0	0	0	7700	739	26	4	148	4	IL1RAPL1	23	29301114	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5367279	29301114	125969446	2081	51970											
DMD	1756	broad.mit.edu	37	chrX	32305752	32305752	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcgttgcactttgcaatgCtgctgtcttcttgctatgaa	7	15	10	9	1	2	1	0	1	2	0	2	1	2	1	0	1	5	6	0	1	3	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:32305752C>A	uc004dda.1	-	43	6428	c.6184G>T	c.(6184-6186)GCA>TCA	p.A2062S	DMD_uc004dcw.2_Missense_Mutation_p.A718S|DMD_uc004dcx.2_Missense_Mutation_p.A721S|DMD_uc004dcz.2_Missense_Mutation_p.A1939S|DMD_uc004dcy.1_Missense_Mutation_p.A2058S|DMD_uc004ddb.1_Missense_Mutation_p.A2054S|DMD_uc010ngo.1_Intron|DMD_uc010ngn.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2062	Spectrin 14.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTTTGCAATGCTGCTGTCTTC	0.368													10	27					1.08611e-07	1.10662e-07	1	0	A	32305752	A	A	32305752	3	1	276	1	0	0	0	0	1	0	0	0	4602	797	28	4	5169	4	DMD	23	32305752	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3004638	32305752	122964808	2082	51971											
FAM47A	158724	broad.mit.edu	37	chrX	34148023	34148023	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtaaattgaaaactgcctaAtcttcttccgatgcctctac	12	13	5	11	1	3	1	0	1	3	0	4	2	4	1	3	0	4	1	3	0	6	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:34148023A>G	uc004ddg.2	-	1	2406	c.2373T>C	c.(2371-2373)GAT>GAC	p.D791D		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	791										ovary(4)|central_nervous_system(1)	5						AAACTGCCTAATCTTCTTCCG	0.383													17	7					0	0	0	0	G	34148023	G	G	34148023	2	3	276	1	0	0	0	0	0	0	0	1	5601	98	4	5		5	FAM47A	23	34148023	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	1842271	34148023	121122537	2083	51972											
FAM47B	170062	broad.mit.edu	37	chrX	34961441	34961441	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctggaggacgcttgggctCgttgtgaggcccgggagaag	7	7	19	8	3	0	2	0	1	0	1	1	5	0	4	1	5	1	4	1	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:34961441C>T	uc004ddi.1	+	1	511	c.493C>T	c.(493-495)CGT>TGT	p.R165C		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	165										ovary(3)|breast(1)	4						CGCTTGGGCTCGTTGTGAGGC	0.597													17	24					0	0	0	0	T	34961441	T	T	34961441	3	4	276	1	0	0	0	0	1	0	0	0	5602	884	31	1	495	1	FAM47B	23	34961441	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	813418	34961441	120309119	2084	51973											
MAGEB16	139604	broad.mit.edu	37	chrX	35821010	35821010	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggaagtgctgaatttgacgGgagtatattctgggaagaag	12	10	16	3	1	1	3	0	2	1	1	1	6	1	6	0	3	1	2	0	3	6	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:35821010G>A	uc010ngt.1	+	2	976	c.697G>A	c.(697-699)GGA>AGA	p.G233R		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	233	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						GAATTTGACGGGAGTATATTC	0.498													13	12					0	0	0	0	A	35821010	A	A	35821010	3	1	276	1	0	0	0	0	1	0	0	0	9227	1233	43	4	699	4	MAGEB16	23	35821010	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	859569	35821010	119449550	2085	51974											
USP9X	8239	broad.mit.edu	37	chrX	41077795	41077795	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agtctttattgcacatttttCcttgcaagatgggccatgtc	8	16	8	9	0	1	1	0	0	1	1	3	1	2	1	2	1	2	2	2	1	2	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:41077795C>T	uc004dfb.2	+	37	7013	c.6380C>T	c.(6379-6381)TCC>TTC	p.S2127F	USP9X_uc004dfc.2_Missense_Mutation_p.S2127F	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2127					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GCACATTTTTCCTTGCAAGAT	0.413													26	78					0	0	0	0	T	41077795	T	T	41077795	3	4	276	1	0	0	0	0	1	0	0	0	17158	855	30	2	6522	2	USP9X	23	41077795	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	5256785	41077795	114192765	2086	51975											
USP9X	8239	broad.mit.edu	37	chrX	41082519	41082519	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgagtgtacctgctactttTatgcttgtgtctttagatga	7	19	9	6	0	1	3	0	2	1	1	1	3	1	3	1	0	4	3	1	0	4	8			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:41082519T>A	uc004dfb.2	+	39	7248	c.6615T>A	c.(6613-6615)TTT>TTA	p.F2205L	USP9X_uc004dfc.2_Missense_Mutation_p.F2205L	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2205					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						CTGCTACTTTTATGCTTGTGT	0.418													33	14					0	0	0	0	A	41082519	A	A	41082519	3	1	276	1	0	0	0	0	1	0	0	0	17158	1751	61	5	6765	5	USP9X	23	41082519	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	4724	41082519	114188041	2087	51976											
GPR34	2857	broad.mit.edu	37	chrX	41555478	41555478	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttaacacttaagaaaggaGggcataattccacaatgtgt	15	12	8	6	0	0	1	0	0	0	1	1	2	1	2	1	2	1	1	1	2	5	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:41555478G>A	uc004dfp.3	+	3	876	c.592G>A	c.(592-594)GGG>AGG	p.G198R	CASK_uc004dfl.3_Intron|CASK_uc004dfm.3_Intron|CASK_uc004dfn.3_Intron|GPR34_uc004dfq.3_Missense_Mutation_p.G198R|GPR34_uc010nhg.2_Missense_Mutation_p.G198R|GPR34_uc004dfr.3_Missense_Mutation_p.G198R	NM_001097579	NP_001091048	Q9UPC5	GPR34_HUMAN	G protein-coupled receptor 34	198	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						TAAGAAAGGAGGGCATAATTC	0.343													14	31					0	0	0	0	A	41555478	A	A	41555478	3	1	276	1	0	0	0	0	1	0	0	0	6727	1000	35	4	594	4	GPR34	23	41555478	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	472959	41555478	113715082	2088	51977											
CFP	5199	broad.mit.edu	37	chrX	47486606	47486606	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccccgggcagggcttcccagGaggtttctgggagggctcag	5	7	17	12	1	2	0	1	0	1	0	3	2	3	2	3	6	0	4	3	6	0	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:47486606G>A	uc004dig.3	-	5	826	c.700C>T	c.(700-702)CCT>TCT	p.P234S	CFP_uc004dih.2_Missense_Mutation_p.P234S|CFP_uc004dii.1_Missense_Mutation_p.P170S|CFP_uc010nhu.2_Missense_Mutation_p.P234S	NM_001145252	NP_001138724	P27918	PROP_HUMAN	complement factor properdin precursor	234	TSP type-1 3.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3						GGCTTCCCAGGAGGTTTCTGG	0.662													8	7					0	0	0	0	A	47486606	A	A	47486606	3	1	276	1	0	0	0	0	1	0	0	0	3308	1174	41	2	729	2	CFP	23	47486606	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5931128	47486606	107783954	2089	51978											
SLC38A5	92745	broad.mit.edu	37	chrX	48318232	48318232	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccagctgaaggccttgcctgGgaaaagcagctgctgcaggg	9	6	15	11	0	0	1	0	1	0	0	0	2	0	2	3	3	6	5	3	3	3	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:48318232G>A	uc010nid.2	-	15	1277	c.1099C>T	c.(1099-1101)CCA>TCA	p.P367S	SLC38A5_uc004djk.3_Missense_Mutation_p.P316S	NM_033518	NP_277053	Q8WUX1	S38A5_HUMAN	solute carrier family 38, member 5	367	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				ovary(3)	3						GCCTTGCCTGGGAAAAGCAGC	0.577													21	10					0	0	0	0	A	48318232	A	A	48318232	3	1	276	1	0	0	0	0	1	0	0	0	14671	1232	43	4	331	4	SLC38A5	23	48318232	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	831626	48318232	106952328	2090	51979											
DGKK	139189	broad.mit.edu	37	chrX	50147114	50147114	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caaacattgcagtgctgggtCcggtggctgtaactggagta	9	10	14	8	1	0	0	0	0	0	0	1	1	1	1	1	4	4	5	1	4	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:50147114C>T	uc010njr.1	-	5	1071	c.1011G>A	c.(1009-1011)CGG>CGA	p.R337R		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	337	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					AGTGCTGGGTCCGGTGGCTGT	0.438													15	5					0	0	0	0	T	50147114	T	T	50147114	2	4	276	1	0	0	0	0	0	0	0	1	4494	842	30	2		2	DGKK	23	50147114	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1828882	50147114	105123446	2091	51980											
MAGED1	9500	broad.mit.edu	37	chrX	51643373	51643373	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagactagcaagatgaaagTgctgagattcattgcagagg	14	9	13	5	0	1	5	1	3	0	4	1	7	1	5	0	1	3	3	0	1	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:51643373T>G	uc004dpm.2	+	11	2035	c.1940T>G	c.(1939-1941)GTG>GGG	p.V647G	MAGED1_uc004dpn.2_Missense_Mutation_p.V703G|MAGED1_uc004dpo.2_Missense_Mutation_p.V647G	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	647	MAGE.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					AAGATGAAAGTGCTGAGATTC	0.512										Multiple Myeloma(10;0.10)			7	19					0	0	0	0	G	51643373	G	G	51643373	3	3	276	1	0	0	0	0	1	0	0	0	9236	1696	59	5	2150	5	MAGED1	23	51643373	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	1496259	51643373	103627187	2092	51981											
HUWE1	10075	broad.mit.edu	37	chrX	53588762	53588762	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcaatgatgagatcatcctCccggtcaaagcgctcaaatc	12	9	7	13	2	4	2	4	2	0	1	7	3	6	2	2	1	1	1	2	1	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:53588762C>T	uc004dsp.2	-	55	7864	c.7462G>A	c.(7462-7464)GAG>AAG	p.E2488K	HUWE1_uc004dsn.2_Missense_Mutation_p.E1312K	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2488	Asp-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGATCATCCTCCCGGTCAAAG	0.458													38	13					0	0	0	0	T	53588762	T	T	53588762	3	4	276	1	0	0	0	0	1	0	0	0	7500	864	30	2	5782	2	HUWE1	23	53588762	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1945389	53588762	101681798	2093	51982											
MAGED2	10916	broad.mit.edu	37	chrX	54837732	54837732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	taaagaccagacgaagattcCcatcaagcgctcgggtaaag	15	6	10	10	3	1	3	1	0	0	3	3	4	2	3	2	1	1	2	2	1	6	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:54837732C>T	uc004dtk.1	+	5	990	c.896C>T	c.(895-897)CCC>CTC	p.P299L	MAGED2_uc004dtl.1_Missense_Mutation_p.P299L|MAGED2_uc004dtm.1_Missense_Mutation_p.P214L|MAGED2_uc010nkc.1_Missense_Mutation_p.P299L|MAGED2_uc004dtn.1_Missense_Mutation_p.P299L|MAGED2_uc004dto.1_Missense_Mutation_p.P273L	NM_177433	NP_803182	Q9UNF1	MAGD2_HUMAN	melanoma antigen family D, 2	299	MAGE.									ovary(2)|breast(1)	3						ACGAAGATTCCCATCAAGCGC	0.478													16	37					0	0	0	0	T	54837732	T	T	54837732	3	4	276	1	0	0	0	0	1	0	0	0	9237	623	22	4	910	4	MAGED2	23	54837732	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1248970	54837732	100432828	2094	51983											
FOXR2	139628	broad.mit.edu	37	chrX	55650779	55650779	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aagaaacaacccccactgtgGcctcagtgtgcaggagatct	12	7	10	12	0	2	2	1	0	1	2	2	3	2	2	3	2	3	1	3	2	3	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:55650779G>A	uc004duo.2	+	1	947	c.635G>A	c.(634-636)GGC>GAC	p.G212D		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	212	Fork-head.				embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						CCCCACTGTGGCCTCAGTGTG	0.493													36	60					0	0	0	0	A	55650779	A	A	55650779	3	1	276	1	0	0	0	0	1	0	0	0	6066	1203	42	4	637	4	FOXR2	23	55650779	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	813047	55650779	99619781	2095	51984											
UPRT	139596	broad.mit.edu	37	chrX	74519598	74519598	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggaacaaggtttacgagaCtgctgtcgatccatacgaat	13	10	10	8	3	0	1	0	0	0	1	2	5	1	2	1	2	4	2	1	2	5	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:74519598C>T	uc004ecb.1	+	5	720	c.591C>T	c.(589-591)GAC>GAT	p.D197D	UPRT_uc004ecc.1_RNA|UPRT_uc004ecd.1_Silent_p.D197D|UPRT_uc004ece.1_Silent_p.D61D	NM_145052	NP_659489	Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog	197					nucleoside metabolic process	cytoplasm|nucleus					0						GTTTACGAGACTGCTGTCGAT	0.408													46	12					0	0	0	0	T	74519598	T	T	74519598	2	4	276	1	0	0	0	0	0	0	0	1	17082	564	20	4		4	UPRT	23	74519598	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	18868819	74519598	80750962	2096	51985											
ATRX	546	broad.mit.edu	37	chrX	76890177	76890177	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacagactcacagcagcaatCccacataaactgaacaccta	17	5	4	15	0	1	2	1	1	0	1	2	2	2	2	2	0	4	2	2	0	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:76890177C>T	uc004ecp.3	-	17	4949	c.4717G>A	c.(4717-4719)GAT>AAT	p.D1573N	ATRX_uc004ecq.3_Missense_Mutation_p.D1535N|ATRX_uc004eco.3_Missense_Mutation_p.D1358N	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1573					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CAGCAGCAATCCCACATAAAC	0.363			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						207	55					0	0	0	0	T	76890177	T	T	76890177	3	4	276	1	0	0	0	0	1	0	0	0	1210	855	30	2	2837	2	ATRX	23	76890177	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2370579	76890177	78380383	2097	51986											
KLHL4	56062	broad.mit.edu	37	chrX	86773151	86773151	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaccggcccctgcccatcaGagagccgttcagaatttgca	9	7	11	14	2	2	2	2	0	0	2	2	4	2	3	5	2	3	2	5	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:86773151G>A	uc004efb.2	+	1	437	c.255G>A	c.(253-255)CAG>CAA	p.Q85Q	KLHL4_uc004efa.2_Silent_p.Q85Q	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	85						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CTGCCCATCAGAGAGCCGTTC	0.453													8	46					0	0	0	0	A	86773151	A	A	86773151	2	1	276	1	0	0	0	0	0	0	0	1	8430	933	33	2		2	KLHL4	23	86773151	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	9882974	86773151	68497409	2098	51987											
KLHL4	56062	broad.mit.edu	37	chrX	86873069	86873069	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttcaaactgcttagggattCgatcatttggagatgcccaa	11	12	9	9	1	2	1	2	0	0	1	3	4	2	2	1	2	3	1	1	2	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:86873069C>T	uc004efb.2	+	4	1044	c.862C>T	c.(862-864)CGA>TGA	p.R288*	KLHL4_uc004efa.2_Nonsense_Mutation_p.R288*	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	288						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CTTAGGGATTCGATCATTTGG	0.418													10	42					0	0	0	0	T	86873069	T	T	86873069	4	4	276	1	0	0	0	0	0	1	0	0	8430	876	31	1	876	1	KLHL4	23	86873069	Nonsense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	99918	86873069	68397491	2099	51988											
TGIF2LX	90316	broad.mit.edu	37	chrX	89177627	89177627	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggagtcggcccctagccaGaagctcaccggaatagccca	10	4	11	16	3	1	1	1	0	0	1	2	3	1	3	6	3	3	1	6	3	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:89177627G>T	uc004efe.2	+	2	592	c.543G>T	c.(541-543)CAG>CAT	p.Q181H		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	181						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CCCCTAGCCAGAAGCTCACCG	0.562													5	42					5.18039e-06	5.26341e-06	1	0	T	89177627	T	T	89177627	3	4	276	1	0	0	0	0	1	0	0	0	15893	933	33	2	545	2	TGIF2LX	23	89177627	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	2304558	89177627	66092933	2100	51989											
PCDH11X	27328	broad.mit.edu	37	chrX	91132697	91132697	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcctggcatccagttgacGaaagtaagtgcaatggatgc	11	10	11	9	1	1	1	0	1	1	0	3	3	2	2	2	2	2	4	2	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:91132697G>A	uc004efk.1	+	2	2303	c.1458G>A	c.(1456-1458)ACG>ACA	p.T486T	PCDH11X_uc004efl.1_Silent_p.T486T|PCDH11X_uc004efo.1_Silent_p.T486T|PCDH11X_uc010nmv.1_Silent_p.T486T|PCDH11X_uc004efm.1_Silent_p.T486T|PCDH11X_uc004efn.1_Silent_p.T486T|PCDH11X_uc004efh.1_Silent_p.T486T|PCDH11X_uc004efj.1_Silent_p.T486T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	486	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TCCAGTTGACGAAAGTAAGTG	0.443													70	22					0	0	0	0	A	91132697	A	A	91132697	2	1	276	1	0	0	0	0	0	0	0	1	11562	1045	37	1		1	PCDH11X	23	91132697	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1955070	91132697	64137863	2101	51990											
PCDH11X	27328	broad.mit.edu	37	chrX	91642907	91642908	+	Missense_Mutation	DNP	GG	AA	AA																															cccagcaatcgcactgaaggGgatggcaactccgatcctga																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:91642907_91642908GG>AA	uc004efk.1	+	5	4163_4164	c.3318_3319GG>AA	c.(3316-3321)GGGGAT>GGAAAT	p.D1107N	PCDH11X_uc004efl.1_Missense_Mutation_p.D1097N|PCDH11X_uc004efo.1_Missense_Mutation_p.D1070N|PCDH11X_uc010nmv.1_Intron|PCDH11X_uc004efm.1_Missense_Mutation_p.D1107N|PCDH11X_uc004efn.1_Missense_Mutation_p.D1097N	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1107	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GCACTGAAGGGGATGGCAACTC	0.485													33	10					0	0	0	0	AA	91642908	AA	AA	91642907	3	1	276	1	0	0	0	0	1	0	0	0	11562	1219	43	4	3458	4	PCDH11X	23	91642907	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	510210	91642907	63627653	2102	51991											
DIAPH2	1730	broad.mit.edu	37	chrX	96369956	96369956	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggatttaagatcaacttcCtttgtaaggtaagatgacat	13	14	9	5	0	1	3	1	1	0	2	2	4	2	4	1	2	1	2	1	2	4	6			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:96369956C>T	uc004efu.3	+	21	2977	c.2581C>T	c.(2581-2583)CTT>TTT	p.L861F	DIAPH2_uc004eft.3_Missense_Mutation_p.L861F	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	861	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						GATCAACTTCCTTTGTAAGGT	0.318													17	24					0	0	0	0	T	96369956	T	T	96369956	3	4	276	1	0	0	0	0	1	0	0	0	4541	681	24	4	2663	4	DIAPH2	23	96369956	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	4727049	96369956	58900604	2103	51992											
SRPX2	27286	broad.mit.edu	37	chrX	99920267	99920267	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccccccaagatccgctgtcCccactcacgtgagaagatgg	9	7	9	16	2	1	3	1	1	0	3	4	4	4	3	6	1	0	1	6	1	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:99920267C>T	uc004egb.2	+	6	1040	c.560C>T	c.(559-561)CCC>CTC	p.P187L		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	187	HYR.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						ATCCGCTGTCCCCACTCACGT	0.527													6	15					0	0	0	0	T	99920267	T	T	99920267	3	4	276	1	0	0	0	0	1	0	0	0	15231	623	22	4	578	4	SRPX2	23	99920267	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3550311	99920267	55350293	2104	51993											
GPRASP1	9737	broad.mit.edu	37	chrX	101910958	101910958	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaagaggacattgtcaattCgtggttctggtccagaaaat	12	11	12	6	1	2	2	1	0	1	2	4	4	3	4	1	4	0	1	1	4	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:101910958C>T	uc004ejj.3	+	5	2918	c.2117C>T	c.(2116-2118)TCG>TTG	p.S706L	GPRASP1_uc004eji.3_Missense_Mutation_p.S706L|GPRASP1_uc010nod.2_Missense_Mutation_p.S706L	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	706	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						ATTGTCAATTCGTGGTTCTGG	0.473													49	91					0	0	0	0	T	101910958	T	T	101910958	3	4	276	1	0	0	0	0	1	0	0	0	6761	893	31	1	2119	1	GPRASP1	23	101910958	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1990691	101910958	53359602	2105	51994											
TSC22D3	1831	broad.mit.edu	37	chrX	106957810	106957811	+	Missense_Mutation	DNP	GG	AA	AA																															attcgggagctggctcttcaGggctcagacaggactggaac																										TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:106957810_106957811GG>AA	uc004eng.2	-	3	593_594	c.343_344CC>TT	c.(343-345)CCT>TTT	p.P115F	TSC22D3_uc004enf.2_Missense_Mutation_p.P58F|TSC22D3_uc004enh.2_Missense_Mutation_p.P181F|TSC22D3_uc004eni.2_Missense_Mutation_p.P181F|TSC22D3_uc004enj.2_Missense_Mutation_p.P181F	NM_004089	NP_004080	Q99576	T22D3_HUMAN	TSC22 domain family, member 3 isoform 2	115							sequence-specific DNA binding transcription factor activity				0						TGGCTCTTCAGGGCTCAGACAG	0.594													101	20					0	0	0	0	AA	106957811	AA	AA	106957810	3	1	276	1	0	0	0	0	1	0	0	0	16676	1000	35	4	64	4	TSC22D3	23	106957810	Missense_Mutation	DNP	GG	TCGA-D6-6516-01A-11D-1870-08	5046852	106957810	48312750	2106	51995											
AMOT	154796	broad.mit.edu	37	chrX	112021852	112021852	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcccaggatctgaatgggAgtttttctttccagagtatt	8	16	10	7	0	2	2	0	1	2	1	4	4	4	4	2	2	0	2	2	2	2	5			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:112021852A>G	uc004epr.2	-	11	3198	c.3198T>C	c.(3196-3198)ACT>ACC	p.T1066T	AMOT_uc004eps.2_Silent_p.T657T	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	1066					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						TCTGAATGGGAGTTTTTCTTT	0.403													70	241					0	0	0	0	G	112021852	G	G	112021852	2	3	276	1	0	0	0	0	0	0	0	1	582	291	11	5		5	AMOT	23	112021852	Silent	SNP	A	TCGA-D6-6516-01A-11D-1870-08	5064042	112021852	43248708	2107	51996											
ZCCHC12	170261	broad.mit.edu	37	chrX	117960306	117960306	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtgacaacgagagtgacaagGcccaggtttttgagaatttg	12	10	13	6	1	0	4	0	3	0	2	0	6	0	4	1	2	1	1	1	2	3	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:117960306G>A	uc004equ.2	+	4	1572	c.1099G>A	c.(1099-1101)GCC>ACC	p.A367T		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	367					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						GAGTGACAAGGCCCAGGTTTT	0.498													17	75					0	0	0	0	A	117960306	A	A	117960306	3	1	276	1	0	0	0	0	1	0	0	0	17648	1203	42	4	1101	4	ZCCHC12	23	117960306	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	5938454	117960306	37310254	2108	51997											
ATP1B4	23439	broad.mit.edu	37	chrX	119513343	119513343	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcaggttaactacacatccCccttggtggcaatgcacttt	9	12	8	12	0	0	0	0	0	0	0	1	0	1	0	2	3	4	4	2	3	3	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:119513343C>T	uc004esr.2	+	8	1012	c.928C>T	c.(928-930)CCC>TCC	p.P310S	ATP1B4_uc004esq.2_Missense_Mutation_p.P306S|ATP1B4_uc011mtx.1_Missense_Mutation_p.P275S|ATP1B4_uc011mty.1_Missense_Mutation_p.P267S	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	310	Perinuclear space (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						CTACACATCCCCCTTGGTGGC	0.473													67	139					0	0	0	0	T	119513343	T	T	119513343	3	4	276	1	0	0	0	0	1	0	0	0	1137	623	22	4	958	4	ATP1B4	23	119513343	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	1553037	119513343	35757217	2109	51998											
GLUD2	2747	broad.mit.edu	37	chrX	120181905	120181905	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagtctctccttccccatcCggcgcgacgacggctcctgg	4	9	11	17	5	1	1	0	1	1	0	6	3	5	1	5	3	0	1	5	3	0	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:120181905C>T	uc004eto.2	+	1	444	c.367C>T	c.(367-369)CGG>TGG	p.R123W		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	123					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	CTTCCCCATCCGGCGCGACGA	0.642													26	28					0	0	0	0	T	120181905	T	T	120181905	3	4	276	1	0	0	0	0	1	0	0	0	6514	643	23	1	369	1	GLUD2	23	120181905	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	668562	120181905	35088655	2110	51999											
ODZ1	10178	broad.mit.edu	37	chrX	123554341	123554341	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caagccatagcggcattccgCctgcatcacggcgaatgtgc	9	7	11	14	4	1	0	1	0	0	0	2	1	2	0	3	2	4	2	3	2	3	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:123554341C>T	uc004euj.2	-	24	4845	c.4781G>A	c.(4780-4782)GGC>GAC	p.G1594D	ODZ1_uc011muj.1_Missense_Mutation_p.G1600D|ODZ1_uc010nqy.2_Missense_Mutation_p.G1601D	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1594	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CGGCATTCCGCCTGCATCACG	0.493													9	39					0	0	0	0	T	123554341	T	T	123554341	3	4	276	1	0	0	0	0	1	0	0	0	10888	739	26	4	3428	4	ODZ1	23	123554341	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	3372436	123554341	31716219	2111	52000											
ACTRT1	139741	broad.mit.edu	37	chrX	127185831	127185831	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catttctgctagcttttctcGaatttccctaggattcaaag	9	16	6	10	1	3	0	1	0	2	0	5	2	4	1	1	1	2	2	1	1	4	7			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:127185831G>A	uc004eum.2	-	1	552	c.355C>T	c.(355-357)CGA>TGA	p.R119*		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	119						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						AGCTTTTCTCGAATTTCCCTA	0.493													251	72					0	0	0	0	A	127185831	A	A	127185831	4	1	276	1	0	0	0	0	0	1	0	0	218	1066	37	1	779	1	ACTRT1	23	127185831	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	3631490	127185831	28084729	2112	52001											
SASH3	54440	broad.mit.edu	37	chrX	128926347	128926347	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccaggttctggcagcttcggGgaggaaccacctgcccccca	7	6	12	16	1	1	0	0	0	1	0	2	2	1	2	6	5	3	3	6	5	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:128926347G>A	uc011mun.1	+	5	668	c.486G>A	c.(484-486)GGG>GGA	p.G162G	SASH3_uc004euu.2_Silent_p.G162G|SASH3_uc011muo.1_Silent_p.G79G	NM_018990	NP_061863	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	162										ovary(2)|pancreas(1)	3						GCAGCTTCGGGGAGGAACCAC	0.627													29	102					0	0	0	0	A	128926347	A	A	128926347	2	1	276	1	0	0	0	0	0	0	0	1	13914	1219	43	4		4	SASH3	23	128926347	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	1740516	128926347	26344213	2113	52002											
GPR119	139760	broad.mit.edu	37	chrX	129519167	129519167	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggcagctgcggaggaagtGacaaatgccatccgcaggct	11	5	15	10	2	0	1	0	1	0	0	1	4	1	3	2	4	3	4	2	4	2	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:129519167G>A	uc011muv.1	-	1	255	c.255C>T	c.(253-255)GTC>GTT	p.V85V		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	85	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						CGGAGGAAGTGACAAATGCCA	0.567													25	147					0	0	0	0	A	129519167	A	A	129519167	2	1	276	1	0	0	0	0	0	0	0	1	6672	1277	45	2		2	GPR119	23	129519167	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	592820	129519167	25751393	2114	52003											
ARHGAP36	158763	broad.mit.edu	37	chrX	130217753	130217753	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcctggaagaggtcctggTgaacgagtttacccgccgca	9	8	13	11	3	0	2	0	1	0	1	1	4	1	3	4	3	3	2	4	3	4	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:130217753T>G	uc004evz.2	+	4	710	c.365T>G	c.(364-366)GTG>GGG	p.V122G	ARHGAP36_uc004ewa.2_Missense_Mutation_p.V110G|ARHGAP36_uc004ewb.2_Missense_Mutation_p.V91G|ARHGAP36_uc004ewc.2_5'UTR	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	122					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						GAGGTCCTGGTGAACGAGTTT	0.552													115	75					0	0	0	0	G	130217753	G	G	130217753	3	3	276	1	0	0	0	0	1	0	0	0	883	1696	59	5	375	5	ARHGAP36	23	130217753	Missense_Mutation	SNP	T	TCGA-D6-6516-01A-11D-1870-08	698586	130217753	25052807	2115	52004											
IGSF1	3547	broad.mit.edu	37	chrX	130411004	130411004	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccctccatcaccaatgccCaccgaaatgattagaaagtg	13	9	6	13	1	1	2	1	1	0	1	3	3	3	2	5	0	1	0	5	0	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:130411004C>T	uc004ewd.2	-	14	2755	c.2517G>A	c.(2515-2517)GTG>GTA	p.V839V	IGSF1_uc004ewe.3_Silent_p.V833V|IGSF1_uc004ewf.2_Silent_p.V819V	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	839	Extracellular (Potential).|Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CACCAATGCCCACCGAAATGA	0.502													71	284					0	0	0	0	T	130411004	T	T	130411004	2	4	276	1	0	0	0	0	0	0	0	1	7635	581	21	4		4	IGSF1	23	130411004	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	193251	130411004	24859556	2116	52005											
IGSF1	3547	broad.mit.edu	37	chrX	130413126	130413126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaaactcaccagtctcttCtatcaataccccattgcaca	14	10	3	14	0	4	0	2	0	2	0	5	1	4	0	3	0	3	1	3	0	5	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:130413126C>T	uc004ewd.2	-	11	1979	c.1741G>A	c.(1741-1743)GAA>AAA	p.E581K	IGSF1_uc004ewe.3_Missense_Mutation_p.E575K|IGSF1_uc004ewf.2_Missense_Mutation_p.E561K	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	581	Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CCAGTCTCTTCTATCAATACC	0.582													81	103					0	0	0	0	T	130413126	T	T	130413126	3	4	276	1	0	0	0	0	1	0	0	0	7635	922	32	2	2309	2	IGSF1	23	130413126	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	2122	130413126	24857434	2117	52006											
SPANXN2	494119	broad.mit.edu	37	chrX	142795189	142795189	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgagtctaggtcttcgtcCtcctgtgaagatccttcagg	7	13	11	10	1	3	3	1	2	2	1	7	4	6	3	3	2	0	0	3	2	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:142795189C>T	uc004fbz.2	-	2	1243	c.489G>A	c.(487-489)GAG>GAA	p.E163E		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	163										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GGTCTTCGTCCTCCTGTGAAG	0.502													82	428					0	0	0	0	T	142795189	T	T	142795189	2	4	276	1	0	0	0	0	0	0	0	1	15057	680	24	4		4	SPANXN2	23	142795189	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	12382063	142795189	12475371	2118	52007											
GABRQ	55879	broad.mit.edu	37	chrX	151821298	151821298	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctaccgaaatccgcaacCgtgtcgaagcccatggccat	10	8	8	15	4	0	0	0	0	0	0	3	2	2	0	6	1	3	1	6	1	4	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:151821298C>T	uc004ffp.1	+	9	1473	c.1453C>T	c.(1453-1455)CGT>TGT	p.R485C		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	485						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AATCCGCAACCGTGTCGAAGC	0.557													24	162					0	0	0	0	T	151821298	T	T	151821298	3	4	276	1	0	0	0	0	1	0	0	0	6209	652	23	1	1487	1	GABRQ	23	151821298	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	9026109	151821298	3449262	2119	52008											
ATP2B3	492	broad.mit.edu	37	chrX	152806879	152806879	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctacgggcagaacttcatcCccccaaagcaacccaagacc	13	5	6	17	1	2	2	1	0	1	2	3	2	3	2	5	1	4	2	5	1	5	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:152806879C>T	uc004fht.1	+	2	397	c.271C>T	c.(271-273)CCC>TCC	p.P91S	ATP2B3_uc004fhs.1_Missense_Mutation_p.P91S	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	91	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GAACTTCATCCCCCCAAAGCA	0.622													14	30					0	0	0	0	T	152806879	T	T	152806879	3	4	276	1	0	0	0	0	1	0	0	0	1143	623	22	4	277	4	ATP2B3	23	152806879	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	985581	152806879	2463681	2120	52009											
ATP2B3	492	broad.mit.edu	37	chrX	152807134	152807134	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtcctccgcacagcctgtggGaatgtgtcgggaggcgcaga	7	7	16	11	3	0	1	0	0	0	1	3	3	2	3	3	3	1	2	3	3	1	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:152807134G>T	uc004fht.1	+	3	540	c.414G>T	c.(412-414)GGG>GGT	p.G138G	ATP2B3_uc004fhs.1_Silent_p.G138G	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	138	Extracellular (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGCCTGTGGGAATGTGTCGG	0.617													49	19					1.83081e-24	1.90596e-24	1	0	T	152807134	T	T	152807134	2	4	276	1	0	0	0	0	0	0	0	1	1143	1161	41	2		2	ATP2B3	23	152807134	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	255	152807134	2463426	2121	52010											
PNCK	139728	broad.mit.edu	37	chrX	152938472	152938472	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcgcacactcacgagccgagCctctcgcggatctcgtagac	8	6	11	16	6	3	1	1	0	2	1	5	4	3	2	2	1	2	2	2	1	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:152938472C>T	uc011myu.1	-	2	495	c.309G>A	c.(307-309)AGG>AGA	p.R103R	PNCK_uc011myt.1_Silent_p.R37R|PNCK_uc004fia.2_Silent_p.R32R|PNCK_uc004fhz.3_5'UTR|PNCK_uc010nuh.2_Silent_p.R103R|PNCK_uc011myv.1_5'UTR|PNCK_uc011myw.1_5'UTR	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	pregnancy upregulated non-ubiquitously expressed	20	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					acGAGCCGAGCCTCTCGCGGA	0.343													4	13					0	0	0	0	T	152938472	T	T	152938472	2	4	276	1	0	0	0	0	0	0	0	1	12200	738	26	4		4	PNCK	23	152938472	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	131338	152938472	2332088	2122	52011											
RENBP	5973	broad.mit.edu	37	chrX	153208459	153208459	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agccggggccccctggagctGgggccggcccagtcccgacg	4	3	17	17	4	0	0	0	0	0	0	1	2	1	1	6	6	2	1	6	6	0	0			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:153208459G>A	uc004fjo.1	-	6	705	c.535C>T	c.(535-537)CAG>TAG	p.Q179*	RENBP_uc011mzh.1_Nonsense_Mutation_p.Q179*	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	179					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	CCCTGGAGCTGGGGCCGGCCC	0.692													10	36					0	0	0	0	A	153208459	A	A	153208459	4	1	276	1	0	0	0	0	0	1	0	0	13290	1357	47	4	772	4	RENBP	23	153208459	Nonsense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	269987	153208459	2062101	2123	52012											
HCFC1	3054	broad.mit.edu	37	chrX	153225815	153225815	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtggccagcccgagcacgggGgatgttgtcctccagtgtat	6	9	15	11	2	0	0	0	0	0	0	2	2	2	1	4	3	2	3	4	3	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:153225815G>A	uc004fjp.2	-	7	1483	c.955C>T	c.(955-957)CCC>TCC	p.P319S		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	319				P->S: Eliminates VIC formation and association with VP16. Unable to rescue proliferation in temperature-sensitive arrested cells.	cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGAGCACGGGGGATGTTGTCC	0.617													9	11					0	0	0	0	A	153225815	A	A	153225815	3	1	276	1	0	0	0	0	1	0	0	0	7030	1232	43	4	5232	4	HCFC1	23	153225815	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	17356	153225815	2044745	2124	52013											
TKTL1	8277	broad.mit.edu	37	chrX	153524312	153524312	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccagccgcttgcgaatcCattccatcagggccacatgc	8	8	10	15	2	1	0	1	0	0	0	3	1	3	0	5	2	3	1	5	2	1	2			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:153524312C>T	uc004fkg.2	+	1	286	c.100C>T	c.(100-102)CAT>TAT	p.H34Y	TEX28_uc004fke.2_5'Flank|TEX28_uc004fkf.2_5'Flank|TEX28_uc010nut.1_5'Flank|TKTL1_uc011mzl.1_Missense_Mutation_p.H34Y|TKTL1_uc011mzm.1_Missense_Mutation_p.H34Y	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	34					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTTGCGAATCCATTCCATCAG	0.622													21	112					0	0	0	0	T	153524312	T	T	153524312	3	4	276	1	0	0	0	0	1	0	0	0	16001	594	21	4	102	4	TKTL1	23	153524312	Missense_Mutation	SNP	C	TCGA-D6-6516-01A-11D-1870-08	298497	153524312	1746248	2125	52014											
TKTL1	8277	broad.mit.edu	37	chrX	153539193	153539193	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ttgtcttgctccagctaccgGgtgttctgcctcatgagtga	5	14	11	11	1	3	2	1	2	2	0	4	2	4	2	3	1	4	3	3	1	1	4			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:153539193G>A	uc004fkg.2	+	4	543	c.357G>A	c.(355-357)CGG>CGA	p.R119R	TKTL1_uc011mzl.1_Silent_p.R113R|TKTL1_uc011mzm.1_Intron|TKTL1_uc004fkh.2_Silent_p.R63R	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	119					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCAGCTACCGGGTGTTCTGCC	0.527													68	14					0	0	0	0	A	153539193	A	A	153539193	2	1	276	1	0	0	0	0	0	0	0	1	16001	1219	43	4		4	TKTL1	23	153539193	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	14881	153539193	1731367	2126	52015											
FLNA	2316	broad.mit.edu	37	chrX	153589715	153589715	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccacagcttccagaggaaaGgggctgccaggcacgggcac	10	3	15	13	1	0	1	0	0	0	1	1	2	1	2	3	5	2	4	3	5	1	1			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:153589715G>A	uc004fkk.2	-	21	3417	c.3168C>T	c.(3166-3168)CCC>CCT	p.P1056P	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Silent_p.P1056P	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1056	Filamin 8.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCAGAGGAAAGGGGCTGCCAG	0.632													44	22					0	0	0	0	A	153589715	A	A	153589715	2	1	276	1	0	0	0	0	0	0	0	1	5965	987	35	4		4	FLNA	23	153589715	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08	50522	153589715	1680845	2127	52016											
FLNA	2316	broad.mit.edu	37	chrX	153590083	153590083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cttgctgaggtccaggcttgGagatactgccactgagaaag	10	9	13	9	0	0	3	0	2	0	2	1	5	1	3	2	3	3	2	2	3	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:153590083G>A	uc004fkk.2	-	20	3148	c.2899C>T	c.(2899-2901)CCA>TCA	p.P967S	FLNA_uc010nuu.1_Missense_Mutation_p.P967S	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	967	Filamin 8.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCAGGCTTGGAGATACTGCC	0.562													13	76					0	0	0	0	A	153590083	A	A	153590083	3	1	276	1	0	0	0	0	1	0	0	0	5965	1174	41	2	5160	2	FLNA	23	153590083	Missense_Mutation	SNP	G	TCGA-D6-6516-01A-11D-1870-08	368	153590083	1680477	2128	52017											
ATP6AP1	537	broad.mit.edu	37	chrX	153660716	153660716	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaagctcggggccagcccCttgcatgtggacctggccac	7	6	14	14	1	0	1	0	0	0	1	1	3	0	2	5	4	3	2	5	4	1	1	rs142472086		TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrX:153660716C>T	uc004flf.1	+	4	529	c.468C>T	c.(466-468)CCC>CCT	p.P156P	ATP6AP1_uc004flg.1_RNA|ATP6AP1_uc004flh.1_Silent_p.P116P	NM_001183	NP_001174	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory	156					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(3)|breast(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGCCAGCCCCTTGCATGTGG	0.647													3	27					0	0	0	0	T	153660716	T	T	153660716	2	4	276	1	0	0	0	0	0	0	0	1	1167	668	24	4		4	ATP6AP1	23	153660716	Silent	SNP	C	TCGA-D6-6516-01A-11D-1870-08	70633	153660716	1609844	2129	52018											
KDM5D	8284	broad.mit.edu	37	chrY	21869120	21869120	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctcctctggtctgggtttGgcctgtagctgttggcgaag	3	13	15	10	1	2	0	0	0	2	0	3	1	3	0	3	4	1	4	3	4	2	3			TCGA-D6-6516-01A-11D-1870-08	TCGA-D6-6516-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5ab94b24-1a1f-4df7-a5c6-b1dce8ee9be5	f4ce50e1-fd2a-46cc-bb02-fd145d98ddab	g.chrY:21869120G>T	uc004fug.2	-	24	4200	c.3912C>A	c.(3910-3912)GCC>GCA	p.A1304A	KDM5D_uc011naz.1_Silent_p.A1335A|KDM5D_uc010nwy.2_Silent_p.A1247A|KDM5D_uc004fuf.2_Silent_p.A479A	NM_004653	NP_004644	Q9BY66	KDM5D_HUMAN	jumonji, AT rich interactive domain 1D isoform	1304					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1					Vitamin C(DB00126)	GTCTGGGTTTGGCCTGTAGCT	0.557													3	3					6.4e-05	6.48179e-05	1	0	T	21869120	T	T	21869120	2	4	276	1	0	0	0	0	0	0	0	1	8175	1335	47	4		4	KDM5D	24	21869120	Silent	SNP	G	TCGA-D6-6516-01A-11D-1870-08		21869120	37504446	2130	52019											
NBPF1	55672	broad.mit.edu	37	chr1	16892272	16892272	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcctgcaagacttcaggctCtactgcctccagcagctccc	7	9	8	17	0	2	1	1	0	1	1	5	1	5	1	4	1	5	4	4	1	2	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:16892272C>G	uc009vos.1	-	28	4033	c.3145G>C	c.(3145-3147)GAG>CAG	p.E1049Q	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1049	NBPF 7.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ACTTCAGGCTCTACTGCCTCC	0.483													21	395					0	0	0	0	G	16892272	G	G	16892272	3	3	277	1	0	0	0	0	1	0	0	0	10245	922	32	2	511	2	NBPF1	1	16892272	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08		16892272	232358349	1	52020											
EPHB2	2048	broad.mit.edu	37	chr1	23219501	23219501	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caccgtggcaggttacgggcGctacagcggcaagatgtact	9	7	14	11	4	0	1	0	0	0	1	0	1	0	1	1	4	4	5	1	4	4	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:23219501G>A	uc009vqj.1	+	7	1698	c.1553G>A	c.(1552-1554)CGC>CAC	p.R518H	EPHB2_uc001bge.2_Missense_Mutation_p.R518H|EPHB2_uc001bgf.2_Missense_Mutation_p.R518H|EPHB2_uc010odu.1_Missense_Mutation_p.R518H	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	518	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GGTTACGGGCGCTACAGCGGC	0.577									Hereditary_Prostate_Cancer				19	50					0	0	0	0	A	23219501	A	A	23219501	3	1	277	1	0	0	0	0	1	0	0	0	5199	1087	38	1	1579	1	EPHB2	1	23219501	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	6327229	23219501	226031120	2	52021											
NRD1	4898	broad.mit.edu	37	chr1	52256303	52256304	+	Frame_Shift_Ins	INS	-	CC	CC																															gtatcctcacactccttcagINScttgatgagagctgtgacct																										TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:52256303_52256304insCC	uc001ctc.3	-	31	3595_3596	c.3273_3274insGG	c.(3271-3276)AAGCTGfs	p.K1091fs	NRD1_uc009vzb.2_Frame_Shift_Ins_p.K786fs|NRD1_uc001ctd.3_Frame_Shift_Ins_p.K1023fs|NRD1_uc001cte.2_Frame_Shift_Ins_p.K959fs	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	1022_1023					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						CACTCCTTCAGCTTGATGAGAG	0.545													---	---	---								CC	52256304	CC	CC	52256303	7	5	277	1	0	1	1	0	0	0	0	0	10699	962	34	0	397	0	NRD1	1	52256303	Frame_Shift_Ins	INS	-	TCGA-D6-6517-01A-11D-1870-08	29036802	52256303	196994318	3	52022											
AK3L1	205	broad.mit.edu	37	chr1	65684449	65684449	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatttaggttttcctaggaCattaggacaagccgaagccc	11	10	10	10	1	0	0	0	0	0	0	1	3	1	2	3	3	2	2	3	3	5	6			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:65684449C>T	uc001dby.2	+	4	525	c.278C>T	c.(277-279)ACA>ATA	p.T93I	AK3L1_uc009wan.2_Missense_Mutation_p.T41I|AK3L1_uc001dbz.2_Missense_Mutation_p.T93I|AK3L1_uc001dca.2_Missense_Mutation_p.T93I	NM_203464	NP_982289	P27144	KAD4_HUMAN	adenylate kinase 3-like 1 isoform 7	93	AMP.					mitochondrial matrix	adenylate kinase activity|ATP binding|GTP binding				0						TTTCCTAGGACATTAGGACAA	0.388													9	42					0	0	0	0	T	65684449	T	T	65684449	3	4	277	1	0	0	0	0	1	0	0	0	442	478	17	4	288	4	AK3L1	1	65684449	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	13428146	65684449	183566172	4	52023											
C1orf173	127254	broad.mit.edu	37	chr1	75072553	75072553	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctagatttcggcaaagaCggttttttgtcaaggcccat	9	14	9	9	2	1	2	1	0	0	2	3	2	2	2	2	3	0	2	2	3	3	6			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:75072553C>T	uc001dgg.2	-	10	1440	c.1221G>A	c.(1219-1221)CCG>CCA	p.P407P	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.P201P	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	407										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCGGCAAAGACGGTTTTTTGT	0.418													23	115					0	0	0	0	T	75072553	T	T	75072553	2	4	277	1	0	0	0	0	0	0	0	1	2023	523	19	1		1	C1orf173	1	75072553	Silent	SNP	C	TCGA-D6-6517-01A-11D-1870-08	9388104	75072553	174178068	5	52024											
CCDC76	54482	broad.mit.edu	37	chr1	100602603	100602603	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgaagatcaactagcaaagCatttgaaaaaatgtaactca	20	9	6	6	0	2	3	2	2	0	1	2	3	2	3	0	0	4	3	0	0	8	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:100602603C>A	uc001dsv.2	+	3	242	c.223C>A	c.(223-225)CAT>AAT	p.H75N	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Missense_Mutation_p.H75N	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	75	CHHC-type.				tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		ACTAGCAAAGCATTTGAAAAA	0.318													10	55					2.80697e-09	3.48452e-09	1	0	A	100602603	A	A	100602603	3	1	277	1	0	0	0	0	1	0	0	0	2863	710	25	4	233	4	CCDC76	1	100602603	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	25530050	100602603	148648018	6	52025											
RBM15	64783	broad.mit.edu	37	chr1	110884597	110884598	+	Frame_Shift_Ins	INS	-	T	T																															gtagcagggcccaatggttaINStgccattcttttggctgtgc																										TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:110884597_110884598insT	uc001dzl.1	+	1	2653_2654	c.2570_2571insT	c.(2569-2571)TATfs	p.Y857fs	RBM15_uc001dzm.1_Frame_Shift_Ins_p.Y857fs|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	857	SPOC.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCCAATGGTTATGCCATTCTTT	0.54			T	MKL1	acute megakaryocytic leukemia								---	---	---								T	110884598	T	T	110884597	7	5	277	1	0	1	1	0	0	0	0	0	13181	449	16	0	2572	0	RBM15	1	110884597	Frame_Shift_Ins	INS	-	TCGA-D6-6517-01A-11D-1870-08	10281994	110884597	138366024	7	52026											
C1orf51	148523	broad.mit.edu	37	chr1	150255844	150255844	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggcagaggggaggttcacGgcccagcccgggtcctatcc	6	6	16	13	2	1	1	1	0	0	1	3	2	3	2	4	6	1	2	4	6	1	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:150255844G>C	uc001euh.2	+	2	303	c.167G>C	c.(166-168)CGG>CCG	p.R56P	C1orf51_uc001eui.2_Intron|C1orf51_uc001euj.2_Missense_Mutation_p.R56P	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	56											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGAGGTTCACGGCCCAGCCCG	0.602													8	170					0	0	0	0	C	150255844	C	C	150255844	3	2	277	1	0	0	0	0	1	0	0	0	2053	1116	39	3	169	3	C1orf51	1	150255844	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	39371247	150255844	98994777	8	52027											
ZNF687	57592	broad.mit.edu	37	chr1	151261022	151261023	+	Frame_Shift_Ins	INS	-	T	T																															ggtgtgcccaacctgccccaINStgatgctccccaatcgctgc																										TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:151261022_151261023insT	uc001exq.2	+	3	2232_2233	c.2134_2135insT	c.(2134-2136)ATGfs	p.M712fs	ZNF687_uc009wmo.2_Frame_Shift_Ins_p.M712fs|ZNF687_uc009wmp.2_Frame_Shift_Ins_p.M712fs	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	712	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AACCTGCCCCATGATGCTCCCC	0.574													---	---	---								T	151261023	T	T	151261022	7	5	277	1	0	1	1	0	0	0	0	0	18159	217	8	0	2140	0	ZNF687	1	151261022	Frame_Shift_Ins	INS	-	TCGA-D6-6517-01A-11D-1870-08	1005178	151261022	97989599	9	52028											
OR10R2	343406	broad.mit.edu	37	chr1	158450102	158450102	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttatgatcgctatgctgcCatttgtcaccctctgcatta	7	15	8	11	1	2	1	1	1	1	0	3	1	2	1	2	1	3	4	2	1	3	4			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:158450102C>T	uc010pik.1	+	1	435	c.435C>T	c.(433-435)GCC>GCT	p.A145A	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	145	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					GCTATGCTGCCATTTGTCACC	0.488													45	205					0	0	0	0	T	158450102	T	T	158450102	2	4	277	1	0	0	0	0	0	0	0	1	10971	581	21	4		4	OR10R2	1	158450102	Silent	SNP	C	TCGA-D6-6517-01A-11D-1870-08	7189080	158450102	90800519	10	52029											
PCNXL2	80003	broad.mit.edu	37	chr1	233313598	233313598	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagcagctgactctgccaGattttgatgtaaaaatttag	12	13	9	7	0	2	3	1	2	1	1	2	3	2	3	1	0	3	3	1	0	4	5			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:233313598G>T	uc001hvl.2	-	17	3458	c.3223C>A	c.(3223-3225)CTG>ATG	p.L1075M	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1075						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GACTCTGCCAGATTTTGATGT	0.428													4	52					1.23904e-05	1.43889e-05	1	0	T	233313598	T	T	233313598	3	4	277	1	0	0	0	0	1	0	0	0	11646	933	33	2	3262	2	PCNXL2	1	233313598	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	74863496	233313598	15937023	11	52030											
LCLAT1	253558	broad.mit.edu	37	chr2	30790956	30790956	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtctcgaagtaatgcatttgCtgaaaaaaatggacttcaga	15	11	9	6	1	2	2	1	1	1	1	3	4	2	3	0	1	2	3	0	1	5	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:30790956C>T	uc002rnj.2	+	6	865	c.656C>T	c.(655-657)GCT>GTT	p.A219V	LCLAT1_uc010ymp.1_Missense_Mutation_p.A57V|LCLAT1_uc002rnk.1_Missense_Mutation_p.A219V|LCLAT1_uc002rnl.2_Missense_Mutation_p.A181V|LCLAT1_uc010ymq.1_Missense_Mutation_p.A181V	NM_182551	NP_872357	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1 isoform 1	219					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			ovary(2)	2						AATGCATTTGCTGAAAAAAAT	0.338													10	54					0	0	0	0	T	30790956	T	T	30790956	3	4	277	1	0	0	0	0	1	0	0	0	8717	797	28	4	674	4	LCLAT1	2	30790956	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08		30790956	212408417	12	52031											
MOGS	7841	broad.mit.edu	37	chr2	74689540	74689540	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggagggatcccaccgctgaAccaccagctggtgaaagcct	10	5	13	13	1	0	2	0	2	0	0	1	4	1	4	5	3	3	2	5	3	2	0			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:74689540A>G	uc010ffj.2	-	4	1539	c.1376T>C	c.(1375-1377)GTT>GCT	p.V459A	MOGS_uc010ffh.2_Missense_Mutation_p.V184A|MOGS_uc010yrt.1_Missense_Mutation_p.V340A|MOGS_uc010ffi.2_Missense_Mutation_p.V353A	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	459	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						CCACCGCTGAACCACCAGCTG	0.597													6	34					0	0	0	0	G	74689540	G	G	74689540	3	3	277	1	0	0	0	0	1	0	0	0	9750	43	2	5	1141	5	MOGS	2	74689540	Missense_Mutation	SNP	A	TCGA-D6-6517-01A-11D-1870-08	43898584	74689540	168509833	13	52032											
TGOLN2	10618	broad.mit.edu	37	chr2	85554626	85554627	+	In_Frame_Ins	INS	-	GGT	GGT																															ttgttgggggtgtcttctggINSggtctgcgcctccgcactcg																								rs76078295		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:85554626_85554627insGGT	uc010fgd.1	-	2	517_518	c.228_229insACC	c.(226-231)insACC	p.76_77insT	TGOLN2_uc002soz.2_In_Frame_Ins_p.76_77insT|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_In_Frame_Ins_p.76_77insT|TGOLN2_uc002spc.1_In_Frame_Ins_p.76_77insT	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	76_77	Extracellular (Potential).|14 X 14 AA tandem repeats.|2.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						GTGTCTTCTGGGGTCTGCGCCT	0.599													---	---	---								GGT	85554627	GGT	GGT	85554626	7	5	277	1	0	1	1	0	0	0	0	0	15902	1232	43	0	1096	0	TGOLN2	2	85554626	In_Frame_Ins	INS	-	TCGA-D6-6517-01A-11D-1870-08	10865086	85554626	157644747	14	52033											
REEP1	65055	broad.mit.edu	37	chr2	86459838	86459838	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agaccccggtggtggggggcCcgagggagcaggggcgccgt	5	3	22	11	4	0	1	0	0	0	1	0	3	0	2	4	8	1	1	4	8	0	0			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:86459838C>T	uc002srh.3	-	6	649	c.505G>A	c.(505-507)GGC>AGC	p.G169S	REEP1_uc010ytg.1_Missense_Mutation_p.G148S|REEP1_uc010yth.1_Missense_Mutation_p.G142S|REEP1_uc010yti.1_Silent_p.R90R	NM_022912	NP_075063	Q9H902	REEP1_HUMAN	receptor accessory protein 1 isoform 2	169					cell death|protein insertion into membrane	integral to membrane|mitochondrial membrane	olfactory receptor binding				0						GGTGGGGGGCCCGAGGGAGCA	0.647													9	25					0	0	0	0	T	86459838	T	T	86459838	3	4	277	1	0	0	0	0	1	0	0	0	13269	623	22	4	169	4	REEP1	2	86459838	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	905212	86459838	156739535	15	52034											
WIPF1	7456	broad.mit.edu	37	chr2	175437112	175437112	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgggccacttgggggtgaaaAgggtttcgcagatgtggatc	8	10	17	6	1	0	2	0	1	0	1	2	3	0	3	1	5	0	2	1	5	2	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:175437112A>G	uc002uiy.2	-	6	753	c.421T>C	c.(421-423)TTT>CTT	p.F141L	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.F141L|WIPF1_uc010fqt.1_Missense_Mutation_p.F141L|WIPF1_uc002ujc.1_Missense_Mutation_p.F141L|WIPF1_uc002uiz.2_Missense_Mutation_p.F141L|WIPF1_uc002ujb.1_Missense_Mutation_p.F141L|WIPF1_uc010zep.1_Missense_Mutation_p.F141L	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	141					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						GGGGGTGAAAAGGGTTTCGCA	0.562													3	51					0	0	0	0	G	175437112	G	G	175437112	3	3	277	1	0	0	0	0	1	0	0	0	17435	72	3	5	1106	5	WIPF1	2	175437112	Missense_Mutation	SNP	A	TCGA-D6-6517-01A-11D-1870-08	88977274	175437112	67762261	16	52035											
ERBB4	2066	broad.mit.edu	37	chr2	212426697	212426697	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccttgtgctcgtggacataCtccaacaggcagccatgggg	8	9	12	12	1	0	0	0	0	0	0	3	1	2	1	3	4	4	2	3	4	2	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:212426697C>G	uc002veg.1	-	20	2516	c.2418G>C	c.(2416-2418)GAG>GAC	p.E806D	ERBB4_uc002veh.1_Missense_Mutation_p.E806D|ERBB4_uc010zji.1_Missense_Mutation_p.E796D|ERBB4_uc010zjj.1_Missense_Mutation_p.E796D|ERBB4_uc010fut.1_Missense_Mutation_p.E806D	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	806	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CGTGGACATACTCCAACAGGC	0.483										TSP Lung(8;0.080)			27	106					0	0	0	0	G	212426697	G	G	212426697	3	3	277	1	0	0	0	0	1	0	0	0	5233	564	20	4	1544	4	ERBB4	2	212426697	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	36989585	212426697	30772676	17	52036											
STAB1	23166	broad.mit.edu	37	chr3	52557481	52557481	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttggagctgcatgcctccaaCgccaccctcctaagtgccaa	9	8	8	16	1	0	0	0	0	0	0	2	1	2	1	6	1	5	2	6	1	3	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr3:52557481C>A	uc003dej.2	+	65	7253	c.7179C>A	c.(7177-7179)AAC>AAA	p.N2393K	STAB1_uc003dek.1_Missense_Mutation_p.N408K|STAB1_uc003del.2_Missense_Mutation_p.N280K	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2393	Extracellular (Potential).|FAS1 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ATGCCTCCAACGCCACCCTCC	0.617													9	21					7.48243e-07	9.0798e-07	1	0	A	52557481	A	A	52557481	3	1	277	1	0	0	0	0	1	0	0	0	15303	535	19	3	7437	3	STAB1	3	52557481	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08		52557481	145464949	18	52037											
GTF2E1	2960	broad.mit.edu	37	chr3	120469672	120469672	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaaccactcgccataactaCtacttcatcaattatcgtac	15	11	2	13	2	2	0	2	0	0	0	4	0	2	0	2	0	5	1	2	0	8	6			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr3:120469672C>G	uc003edz.3	+	2	387	c.273C>G	c.(271-273)TAC>TAG	p.Y91*	GTF2E1_uc003edy.2_Nonsense_Mutation_p.Y91*	NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	91	HTH TFE/IIEalpha-type.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		GCCATAACTACTACTTCATCA	0.398													9	38					0	0	0	0	G	120469672	G	G	120469672	4	3	277	1	0	0	0	0	0	1	0	0	6895	576	20	4	275	4	GTF2E1	3	120469672	Nonsense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	67912191	120469672	77552758	19	52038											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	99					0	0	0	0	A	178936082	A	A	178936082	3	1	277	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	58466410	178936082	19086348	20	52039											
MEPE	56955	broad.mit.edu	37	chr4	88755893	88755893	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gttttctgtgtgggactactCcttttcagtgtgacctgggc	4	16	12	9	0	2	1	1	1	1	0	3	2	3	2	2	2	1	1	2	2	1	5			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:88755893C>T	uc003hqy.2	+	2	66	c.27C>T	c.(25-27)CTC>CTT	p.L9L	MEPE_uc010ikn.2_5'UTR	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	9					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		TGGGACTACTCCTTTTCAGTG	0.368													17	76					0	0	0	0	T	88755893	T	T	88755893	2	4	277	1	0	0	0	0	0	0	0	1	9531	842	30	2		2	MEPE	4	88755893	Silent	SNP	C	TCGA-D6-6517-01A-11D-1870-08		88755893	102398383	21	52040											
FAM190A	401145	broad.mit.edu	37	chr4	91229530	91229530	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatgattctcttccttcttCaccttcttccagtaatacag	9	16	3	13	0	4	1	1	1	3	0	7	1	6	1	3	0	1	1	3	0	2	8			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:91229530C>T	uc003hsv.3	+	2	435	c.95C>T	c.(94-96)TCA>TTA	p.S32L	FAM190A_uc003hsu.3_Missense_Mutation_p.S32L|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.S32L	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	32	Ser-rich.									large_intestine(1)|ovary(1)	2						CTTCCTTCTTCACCTTCTTCC	0.468													6	34					0	0	0	0	T	91229530	T	T	91229530	3	4	277	1	0	0	0	0	1	0	0	0	5549	838	29	2	97	2	FAM190A	4	91229530	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	2473637	91229530	99924746	22	52041											
PCDH10	57575	broad.mit.edu	37	chr4	134072815	134072815	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctatcctcgagtgccagaTccagggcatgagcgtcttca	8	10	10	13	2	3	2	1	1	2	1	6	3	5	2	3	1	2	1	3	1	1	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:134072815T>C	uc003iha.2	+	1	2346	c.1520T>C	c.(1519-1521)ATC>ACC	p.I507T	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.I507T	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	507	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GAGTGCCAGATCCAGGGCATG	0.577													22	71					0	0	0	0	C	134072815	C	C	134072815	3	2	277	1	0	0	0	0	1	0	0	0	11561	1435	50	5	1522	5	PCDH10	4	134072815	Missense_Mutation	SNP	T	TCGA-D6-6517-01A-11D-1870-08	42843285	134072815	57081461	23	52042											
SNX25	83891	broad.mit.edu	37	chr4	186283809	186283809	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcaaaatgcccgccacggtAtaataaaaatattcaatgca	18	8	6	9	2	1	0	1	0	0	0	1	0	1	0	2	1	3	3	2	1	9	5			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:186283809A>G	uc003ixh.2	+	18	2575	c.2386A>G	c.(2386-2388)ATA>GTA	p.I796V	SNX25_uc010ish.2_Missense_Mutation_p.I512V|SNX25_uc003ixi.2_Missense_Mutation_p.I300V	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	796					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CCGCCACGGTATAATAAAAAT	0.388													58	194					0	0	0	0	G	186283809	G	G	186283809	3	3	277	1	0	0	0	0	1	0	0	0	14960	449	16	5	2452	5	SNX25	4	186283809	Missense_Mutation	SNP	A	TCGA-D6-6517-01A-11D-1870-08	52210994	186283809	4870467	24	52043											
TAS2R1	50834	broad.mit.edu	37	chr5	9629960	9629960	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caatcacattaacgtagaagAtgaacaactgcagaaaaatt	20	8	6	7	1	1	4	1	1	0	3	1	4	1	4	0	0	4	2	0	0	8	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr5:9629960A>G	uc003jem.1	-	1	504	c.185T>C	c.(184-186)ATC>ACC	p.I62T		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	62	Helical; Name=2; (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						AACGTAGAAGATGAACAACTG	0.368													22	28					0	0	0	0	G	9629960	G	G	9629960	3	3	277	1	0	0	0	0	1	0	0	0	15631	333	12	5	718	5	TAS2R1	5	9629960	Missense_Mutation	SNP	A	TCGA-D6-6517-01A-11D-1870-08		9629960	171285300	25	52044											
MGC42105	167359	broad.mit.edu	37	chr5	43280501	43280501	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aatgatgaatggatgcaaggGgtgccataccctacaccttt	12	10	10	9	0	0	2	0	2	0	0	0	3	0	3	3	3	4	1	3	3	5	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr5:43280501G>C	uc003jno.2	+	4	1862	c.981G>C	c.(979-981)GGG>GGC	p.G327G		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	327							ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						GGATGCAAGGGGTGCCATACC	0.502													17	74					0	0	0	0	C	43280501	C	C	43280501	2	2	277	1	0	0	0	0	0	0	0	1	9605	1219	43	4		4	MGC42105	5	43280501	Silent	SNP	G	TCGA-D6-6517-01A-11D-1870-08	33650541	43280501	137634759	26	52045											
HIST1H2AG	8969	broad.mit.edu	37	chr6	27100994	27100994	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcgggtcggggccggcgcGccggtgtatctggcagcggt	3	6	21	11	7	1	0	0	0	1	0	2	1	1	0	2	7	2	2	2	7	1	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:27100994G>T	uc003niw.2	+	1	178	c.144G>T	c.(142-144)GCG>GCT	p.A48A	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	48					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GGGCCGGCGCGCCGGTGTATC	0.682													14	58					9.31168e-06	1.09311e-05	1	0	T	27100994	T	T	27100994	2	4	277	1	0	0	0	0	0	0	0	1	7172	1074	38	3		3	HIST1H2AG	6	27100994	Silent	SNP	G	TCGA-D6-6517-01A-11D-1870-08		27100994	144014073	27	52046											
OR12D2	26529	broad.mit.edu	37	chr6	29365111	29365111	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgggccccttctttctgaCacttctctcctatttctaca	6	16	4	15	0	4	1	0	1	4	0	6	1	5	1	3	1	1	0	3	1	2	6			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:29365111C>T	uc003nmf.3	+	1	696	c.635C>T	c.(634-636)ACA>ATA	p.T212I		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTCTTTCTGACACTTCTCTCC	0.468													22	147					0	0	0	0	T	29365111	T	T	29365111	3	4	277	1	0	0	0	0	1	0	0	0	10985	478	17	4	637	4	OR12D2	6	29365111	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	2264117	29365111	141749956	28	52047											
VPS52	6293	broad.mit.edu	37	chr6	33234453	33234453	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggaattgtctaggagggCgtagtgctggctgcggaaga	9	8	18	6	2	1	1	0	0	1	1	1	4	1	4	0	5	2	4	0	5	4	3	rs146611103		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:33234453C>T	uc003odm.1	-	12	1372	c.1162G>A	c.(1162-1164)GCC>ACC	p.A388T	VPS52_uc003odn.1_Missense_Mutation_p.A199T	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	388					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						TCTAGGAGGGCGTAGTGCTGG	0.522													7	51					0	0	0	0	T	33234453	T	T	33234453	3	4	277	1	0	0	0	0	1	0	0	0	17282	768	27	1	1045	1	VPS52	6	33234453	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	3869342	33234453	137880614	29	52048											
SLC2A12	154091	broad.mit.edu	37	chr6	134349644	134349644	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attcagtgtggcttaatccaGcatttagcaaggatgctgag	11	12	11	7	0	1	1	1	1	0	0	2	2	2	2	1	2	3	4	1	2	3	4			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:134349644G>A	uc003qem.1	-	2	1490	c.1319C>T	c.(1318-1320)GCT>GTT	p.A440V		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	440	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		GCTTAATCCAGCATTTAGCAA	0.478													21	73					0	0	0	0	A	134349644	A	A	134349644	3	1	277	1	0	0	0	0	1	0	0	0	14605	971	34	4	550	4	SLC2A12	6	134349644	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	101115191	134349644	36765423	30	52049											
LATS1	9113	broad.mit.edu	37	chr6	150001304	150001304	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggaatgaataatatagaCgaactacccattcattgtca	15	12	6	8	1	2	2	2	1	0	1	2	4	2	3	1	1	2	0	1	1	7	7			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:150001304C>A	uc003qmu.1	-	5	2848	c.2300G>T	c.(2299-2301)CGT>CTT	p.R767L	LATS1_uc010kif.1_Missense_Mutation_p.R662L|LATS1_uc003qmv.1_Missense_Mutation_p.R767L	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	767	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		ATAATATAGACGAACTACCCA	0.373													22	58					3.7963e-18	4.82354e-18	1	0	A	150001304	A	A	150001304	3	1	277	1	0	0	0	0	1	0	0	0	8686	536	19	3	1108	3	LATS1	6	150001304	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	15651660	150001304	21113763	31	52050											
TAGAP	117289	broad.mit.edu	37	chr6	159457736	159457736	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccaagttcttgatcttcAggtccaccggcctcttggtt	5	13	11	12	1	4	1	1	1	3	0	5	1	5	1	4	4	0	2	4	4	1	5			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:159457736A>G	uc003qrz.2	-	10	1651	c.1319T>C	c.(1318-1320)CTG>CCG	p.L440P	TAGAP_uc011eft.1_Missense_Mutation_p.L377P|TAGAP_uc003qsa.2_Missense_Mutation_p.L262P	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	440					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CTTGATCTTCAGGTCCACCGG	0.612													4	101					0	0	0	0	G	159457736	G	G	159457736	3	3	277	1	0	0	0	0	1	0	0	0	15603	188	7	5	880	5	TAGAP	6	159457736	Missense_Mutation	SNP	A	TCGA-D6-6517-01A-11D-1870-08	9456432	159457736	11657331	32	52051											
GPR22	2845	broad.mit.edu	37	chr7	107114861	107114861	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctcatttgctgtttccatgAggcttgtgtatcttttgcaa	6	19	8	8	0	2	1	1	1	2	0	4	1	3	1	1	1	2	5	1	1	2	6			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr7:107114861A>G	uc003vef.2	+	3	1702	c.356A>G	c.(355-357)GAG>GGG	p.E119G	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	119	Helical; Name=3; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						TGTTTCCATGAGGCTTGTGTA	0.388													28	81					0	0	0	0	G	107114861	G	G	107114861	3	3	277	1	0	0	0	0	1	0	0	0	6720	304	11	5	358	5	GPR22	7	107114861	Missense_Mutation	SNP	A	TCGA-D6-6517-01A-11D-1870-08		107114861	52023802	33	52052											
GRM8	2918	broad.mit.edu	37	chr7	126746588	126746588	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgaaggcctccacaccgCtctcaccatagttcccctca	8	8	8	17	1	2	1	2	1	1	0	5	1	4	1	6	2	0	2	6	2	2	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr7:126746588C>T	uc003vlr.2	-	2	1000	c.689G>A	c.(688-690)AGC>AAC	p.S230N	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.S230N|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_5'UTR	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	230	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CTCCACACCGCTCTCACCATA	0.507										HNSCC(24;0.065)			10	35					0	0	0	0	T	126746588	T	T	126746588	3	4	277	1	0	0	0	0	1	0	0	0	6842	797	28	4	2123	4	GRM8	7	126746588	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	19631727	126746588	32392075	34	52053											
CSMD1	64478	broad.mit.edu	37	chr8	3351179	3351179	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctggtgtctcccaccttccCagcatcaccaaccgtcaggg	7	9	8	17	1	4	0	2	0	2	0	6	0	5	0	5	2	2	1	5	2	1	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:3351179C>T	uc011kwk.1	-	11	1807	c.1417G>A	c.(1417-1419)GGG>AGG	p.G473R		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	473	CUB 3.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCACCTTCCCAGCATCACCA	0.507													4	9					0	0	0	0	T	3351179	T	T	3351179	3	4	277	1	0	0	0	0	1	0	0	0	3961	594	21	4	9333	4	CSMD1	8	3351179	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08		3351179	143012843	35	52054											
TEX15	56154	broad.mit.edu	37	chr8	30703495	30703495	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagttataagctgcaaagaTgtgtgaactcttctatgagc	12	14	9	6	0	2	3	0	2	2	1	2	3	2	3	0	0	4	3	0	0	6	5			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:30703495T>C	uc003xil.2	-	1	3039	c.3039A>G	c.(3037-3039)ACA>ACG	p.T1013T		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1013										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GCTGCAAAGATGTGTGAACTC	0.343													42	98					0	0	0	0	C	30703495	C	C	30703495	2	2	277	1	0	0	0	0	0	0	0	1	15845	1451	51	5		5	TEX15	8	30703495	Silent	SNP	T	TCGA-D6-6517-01A-11D-1870-08	27352316	30703495	115660527	36	52055											
IDO1	3620	broad.mit.edu	37	chr8	39785691	39785691	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaactgagaaatccctttTgaaggaaggttaatgtaacc	15	11	8	7	0	0	2	0	2	0	1	1	4	1	3	2	2	3	2	2	2	7	5			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:39785691T>G	uc003xnm.2	+	10	1313	c.1199T>G	c.(1198-1200)TTG>TGG	p.L400W	IDO1_uc003xnn.2_RNA	NM_002164	NP_002155	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	400					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)	2					L-Tryptophan(DB00150)	AAATCCCTTTTGAAGGAAGGT	0.398													4	15					0	0	0	0	G	39785691	G	G	39785691	3	3	277	1	0	0	0	0	1	0	0	0	7540	1821	63	5	1237	5	IDO1	8	39785691	Missense_Mutation	SNP	T	TCGA-D6-6517-01A-11D-1870-08	9082196	39785691	106578331	37	52056											
SGK3	23678	broad.mit.edu	37	chr8	67771691	67771691	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgacacagcatttacagaaGaaacagttccatattctgtg	14	12	7	8	0	1	3	0	1	1	2	2	3	2	3	1	0	3	2	1	0	4	6			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:67771691G>C	uc003xwr.2	+	17	1665	c.1366G>C	c.(1366-1368)GAA>CAA	p.E456Q	SGK3_uc003xwp.2_Missense_Mutation_p.E450Q|SGK3_uc003xwt.2_Missense_Mutation_p.E456Q|SGK3_uc003xwu.2_Missense_Mutation_p.E424Q	NM_001033578	NP_001028750	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase 3 isoform	456	AGC-kinase C-terminal.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			ovary(1)|large_intestine(1)|lung(1)|breast(1)	4	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ATTTACAGAAGAAACAGTTCC	0.363													36	72					0	0	0	0	C	67771691	C	C	67771691	3	2	277	1	0	0	0	0	1	0	0	0	14277	943	33	2	1428	2	SGK3	8	67771691	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	27986000	67771691	78592331	38	52057											
ABRA	137735	broad.mit.edu	37	chr8	107782152	107782152	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgagctttgtccatctccAtgtccttctggcaggcgggg	4	13	12	12	1	3	1	0	1	3	0	6	1	5	1	3	4	1	2	3	4	0	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:107782152A>G	uc003ymm.3	-	1	321	c.267T>C	c.(265-267)CAT>CAC	p.H89H		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	89					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			GTCCATCTCCATGTCCTTCTG	0.532													13	129					0	0	0	0	G	107782152	G	G	107782152	2	3	277	1	0	0	0	0	0	0	0	1	100	214	8	5		5	ABRA	8	107782152	Silent	SNP	A	TCGA-D6-6517-01A-11D-1870-08	40010461	107782152	38581870	39	52058											
PPP1R16A	84988	broad.mit.edu	37	chr8	145724384	145724384	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgacagtgagtgctggaCgcctctgcatgctgcggcca	6	9	14	12	2	1	2	0	2	1	0	1	3	1	3	2	2	4	3	2	2	0	0			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:145724384C>T	uc003zdd.2	+	4	1329	c.416C>T	c.(415-417)ACG>ATG	p.T139M	uc003zde.1_5'Flank|PPP1R16A_uc003zdf.2_Missense_Mutation_p.T139M	NM_032902	NP_116291	Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	139	ANK 3.					plasma membrane	protein binding				0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GAGTGCTGGACGCCTCTGCAT	0.622													10	49					0	0	0	0	T	145724384	T	T	145724384	3	4	277	1	0	0	0	0	1	0	0	0	12425	536	19	1	426	1	PPP1R16A	8	145724384	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	37942232	145724384	639638	40	52059											
DDX58	23586	broad.mit.edu	37	chr9	32488812	32488812	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcgcaaaaaagacaactttCcccttttgtccttgtgggaa	11	13	7	10	1	0	1	0	0	0	1	3	2	2	2	3	1	1	1	3	1	5	5			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr9:32488812C>T	uc003zra.2	-	7	1031	c.873G>A	c.(871-873)GGG>GGA	p.G291G	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Silent_p.G246G|DDX58_uc011lnr.1_Silent_p.G88G|DDX58_uc010mji.2_Silent_p.G220G	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	291	Helicase ATP-binding.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		AGACAACTTTCCCCTTTTGTC	0.338													10	29					0	0	0	0	T	32488812	T	T	32488812	2	4	277	1	0	0	0	0	0	0	0	1	4392	842	30	2		2	DDX58	9	32488812	Silent	SNP	C	TCGA-D6-6517-01A-11D-1870-08		32488812	108724619	41	52060											
CAMK1D	57118	broad.mit.edu	37	chr10	12870837	12870837	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaggagttggagccgagcGgagacccaggcccaccactg	9	4	14	14	2	1	1	1	0	0	1	1	5	1	3	4	4	2	1	4	4	0	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:12870837G>A	uc001ilo.2	+	11	1344	c.1109G>A	c.(1108-1110)CGG>CAG	p.R370Q		NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	370						calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		GGAGCCGAGCGGAGACCCAGG	0.642													7	26					0	0	0	0	A	12870837	A	A	12870837	3	1	277	1	0	0	0	0	1	0	0	0	2609	1116	39	1	1186	1	CAMK1D	10	12870837	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08		12870837	122663910	42	52061											
SLC18A3	6572	broad.mit.edu	37	chr10	50819421	50819421	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggagccggagcgcagtcGtgcactgggcgtggcgctgg	5	5	21	10	5	0	0	0	0	0	0	1	3	0	3	1	6	3	3	1	6	0	0			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:50819421G>C	uc001jhw.2	+	1	1075	c.635G>C	c.(634-636)CGT>CCT	p.R212P	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	212	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GAGCGCAGTCGTGCACTGGGC	0.672													4	13					0	0	0	0	C	50819421	C	C	50819421	3	2	277	1	0	0	0	0	1	0	0	0	14492	1145	40	3	637	3	SLC18A3	10	50819421	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	37948584	50819421	84715326	43	52062											
TACR2	6865	broad.mit.edu	37	chr10	71175838	71175838	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggcattgaaggcagccatgCagaggtcagccagcgccaga	11	4	14	12	2	1	3	1	1	0	2	1	3	1	3	3	3	4	3	3	3	1	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:71175838C>T	uc001jpn.2	-	1	837	c.242G>A	c.(241-243)TGC>TAC	p.C81Y		NM_001057	NP_001048	P21452	NK2R_HUMAN	tachykinin receptor 2	81	Helical; Name=2; (Potential).				excretion|muscle contraction	integral to plasma membrane	tachykinin receptor activity			prostate(1)	1					Clonidine(DB00575)|Octreotide(DB00104)	GGCAGCCATGCAGAGGTCAGC	0.547													11	16					0	0	0	0	T	71175838	T	T	71175838	3	4	277	1	0	0	0	0	1	0	0	0	15572	710	25	4	974	4	TACR2	10	71175838	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	20356417	71175838	64358909	44	52063											
LOC729020	729020	broad.mit.edu	37	chr10	105005908	105005908	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caacatcacctttggtcaccCtgtggtagaaagccttcgaa	11	10	8	12	1	2	1	2	0	0	1	3	2	2	1	3	2	2	1	3	2	4	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:105005908C>T	uc009xxi.2	+	1	265	c.155C>T	c.(154-156)CCT>CTT	p.P52L	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	52					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						TTTGGTCACCCTGTGGTAGAA	0.507													37	188					0	0	0	0	T	105005908	T	T	105005908	3	4	277	1	0	0	0	0	1	0	0	0	8938	681	24	4	157	4	LOC729020	10	105005908	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	33830070	105005908	30528839	45	52064											
PDCD11	22984	broad.mit.edu	37	chr10	105201732	105201732	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagaagccacaccaagccacGgtgctgtattttgcagggca	11	7	12	11	1	0	1	0	0	0	1	0	2	0	1	3	2	4	4	3	2	3	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:105201732G>A	uc001kwy.1	+	31	4794	c.4707G>A	c.(4705-4707)ACG>ACA	p.T1569T		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1569					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ACCAAGCCACGGTGCTGTATT	0.572													5	35					0	0	0	0	A	105201732	A	A	105201732	2	1	277	1	0	0	0	0	0	0	0	1	11671	1130	39	1		1	PDCD11	10	105201732	Silent	SNP	G	TCGA-D6-6517-01A-11D-1870-08	195824	105201732	30333015	46	52065											
C11orf41	25758	broad.mit.edu	37	chr11	33564673	33564673	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctccccatctcctgtgccaGaaatgcccactcttccagca	8	9	5	19	0	2	1	0	0	2	1	5	1	4	1	7	0	3	1	7	0	1	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:33564673G>C	uc001mup.3	+	1	797	c.673G>C	c.(673-675)GAA>CAA	p.E225Q	C11orf41_uc001mun.1_Missense_Mutation_p.E225Q	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	225						integral to membrane				ovary(2)	2						TCCTGTGCCAGAAATGCCCAC	0.537											OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	74					0	0	0	0	C	33564673	C	C	33564673	3	2	277	1	0	0	0	0	1	0	0	0	1646	943	33	2	675	2	C11orf41	11	33564673	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08		33564673	101441843	47	52066											
OR5D18	219438	broad.mit.edu	37	chr11	55587567	55587567	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatcctatgcctggggagtCtcatgttccttggaactgac	7	12	12	10	0	1	1	1	1	1	0	4	4	3	4	3	4	2	1	3	4	2	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:55587567C>G	uc010rin.1	+	1	462	c.462C>G	c.(460-462)GTC>GTG	p.V154V		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				CCTGGGGAGTCTCATGTTCCT	0.478													34	138					0	0	0	0	G	55587567	G	G	55587567	2	3	277	1	0	0	0	0	0	0	0	1	11211	900	32	2		2	OR5D18	11	55587567	Silent	SNP	C	TCGA-D6-6517-01A-11D-1870-08	22022894	55587567	79418949	48	52067											
OR5AK2	390181	broad.mit.edu	37	chr11	56756943	56756943	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgatgttccccctattctTgctctttcatgctccaatgt	5	18	6	12	0	3	1	1	1	2	0	5	1	5	1	3	0	2	3	3	0	2	5			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:56756943T>G	uc010rjp.1	+	1	555	c.555T>G	c.(553-555)CTT>CTG	p.L185L		NM_001005323	NP_001005323	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						CCCCTATTCTTGCTCTTTCAT	0.403													48	221					0	0	0	0	G	56756943	G	G	56756943	2	3	277	1	0	0	0	0	0	0	0	1	11196	1799	63	5		5	OR5AK2	11	56756943	Silent	SNP	T	TCGA-D6-6517-01A-11D-1870-08	1169376	56756943	78249573	49	52068											
PICALM	8301	broad.mit.edu	37	chr11	85779753	85779753	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggccttgcatactgtctTggatacggcagagccggtga	7	10	14	10	3	1	2	0	1	1	1	1	3	1	3	2	4	4	2	2	4	2	4			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:85779753T>G	uc001pbm.2	-	1	356	c.70A>C	c.(70-72)AAG>CAG	p.K24Q	PICALM_uc001pbl.2_Missense_Mutation_p.K24Q|PICALM_uc001pbn.2_Missense_Mutation_p.K24Q|PICALM_uc010rtl.1_Intron	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly	24	ENTH.				clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				CATACTGTCTTGGATACGGCA	0.537			T	MLLT10|MLL	TALL|AML|								10	16					0	0	0	0	G	85779753	G	G	85779753	3	3	277	1	0	0	0	0	1	0	0	0	11935	1821	63	5	1996	5	PICALM	11	85779753	Missense_Mutation	SNP	T	TCGA-D6-6517-01A-11D-1870-08	29022810	85779753	49226763	50	52069											
FOXJ2	55810	broad.mit.edu	37	chr12	8200482	8200482	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctccccacctgcaggcttTtcttctctcctgggggacat	4	13	8	16	0	2	0	0	0	2	0	6	1	5	1	5	3	1	2	5	3	0	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:8200482T>A	uc001qtu.2	+	7	1907	c.822T>A	c.(820-822)TTT>TTA	p.F274L	FOXJ2_uc001qtt.1_Missense_Mutation_p.F274L	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	274					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				Kidney(36;0.0944)		CTGCAGGCTTTTCTTCTCTCC	0.368													18	67					0	0	0	0	A	8200482	A	A	8200482	3	1	277	1	0	0	0	0	1	0	0	0	6046	1838	64	5	844	5	FOXJ2	12	8200482	Missense_Mutation	SNP	T	TCGA-D6-6517-01A-11D-1870-08		8200482	125651413	51	52070											
ATF1	466	broad.mit.edu	37	chr12	51173954	51173954	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agattcccacaagagtaccaCgtcagagacagcacctcaac	15	5	7	14	1	2	3	2	0	0	3	3	4	3	3	3	0	3	2	3	0	3	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:51173954C>T	uc001rww.3	+	2	304	c.26C>T	c.(25-27)ACG>ATG	p.T9M	ATF1_uc010smu.1_Translation_Start_Site	NM_005171	NP_005162	P18846	ATF1_HUMAN	activating transcription factor 1	9					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(323)|FUS/ATF1(4)	soft_tissue(321)|ovary(2)|NS(2)|bone(2)|skin(2)	329						AAGAGTACCACGTCAGAGACA	0.408			T	EWSR1|FUS	malignant melanoma of soft parts |angiomatoid fibrous histiocytoma 								68	177					0	0	0	0	T	51173954	T	T	51173954	3	4	277	1	0	0	0	0	1	0	0	0	1081	536	19	1	28	1	ATF1	12	51173954	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	42973472	51173954	82677941	52	52071											
RIC8B	55188	broad.mit.edu	37	chr12	107254159	107254159	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcagaggatgaggacacaGacactgaagaatacaaaaat	20	5	9	7	0	1	5	1	2	0	3	1	7	1	7	0	2	1	0	0	2	5	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:107254159G>T	uc001tlx.2	+	8	1545	c.1420G>T	c.(1420-1422)GAC>TAC	p.D474Y	RIC8B_uc001tlw.2_Missense_Mutation_p.D474Y|RIC8B_uc001tly.2_Missense_Mutation_p.D434Y|RIC8B_uc001tlz.2_RNA|RIC8B_uc009zur.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	474					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						TGAGGACACAGACACTGAAGA	0.438													6	31					3.59834e-05	4.09074e-05	1	0	T	107254159	T	T	107254159	3	4	277	1	0	0	0	0	1	0	0	0	13421	942	33	2	1450	2	RIC8B	12	107254159	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	56080205	107254159	26597736	53	52072											
ATP2A2	488	broad.mit.edu	37	chr12	110783837	110783837	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	accagtccttgctgaggatgCccccctgggagaacatctgg	8	8	12	13	0	1	2	0	1	1	1	2	4	2	3	5	3	3	1	5	3	1	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:110783837C>T	uc001tqk.3	+	19	3336	c.2773C>T	c.(2773-2775)CCC>TCC	p.P925S	ATP2A2_uc001tql.3_Missense_Mutation_p.P925S|ATP2A2_uc010sxy.1_Missense_Mutation_p.P898S|ATP2A2_uc001tqn.3_Missense_Mutation_p.P2S|ATP2A2_uc009zvn.2_5'Flank	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	925	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						GCTGAGGATGCCCCCCTGGGA	0.577													4	83					0	0	0	0	T	110783837	T	T	110783837	3	4	277	1	0	0	0	0	1	0	0	0	1139	739	26	4	2847	4	ATP2A2	12	110783837	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	3529678	110783837	23068058	54	52073											
C12orf52	84934	broad.mit.edu	37	chr12	113624689	113624689	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggcagcccagcaggcacccgGcctaccccaccggacttcga	8	3	11	19	3	0	0	0	0	0	0	1	2	0	1	6	4	3	3	6	4	1	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:113624689G>A	uc001tur.1	+	3	606	c.138G>A	c.(136-138)CGG>CGA	p.R46R	DDX54_uc001tuq.3_5'Flank|DDX54_uc001tup.2_5'Flank|C12orf52_uc009zwg.1_Silent_p.R46R|C12orf52_uc001tus.1_Silent_p.R46R|C12orf52_uc001tut.1_Silent_p.R70R	NM_032848	NP_116237	Q96K30	RITA_HUMAN	hypothetical protein LOC84934	46					negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding				0						CAGGCACCCGGCCTACCCCAC	0.642													7	31					0	0	0	0	A	113624689	A	A	113624689	2	1	277	1	0	0	0	0	0	0	0	1	1703	1190	42	4		4	C12orf52	12	113624689	Silent	SNP	G	TCGA-D6-6517-01A-11D-1870-08	2840852	113624689	20227206	55	52074											
FAM155A	728215	broad.mit.edu	37	chr13	107863084	107863084	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcaaaatactgggaacagAgccaggctttgtagacaatc	14	9	9	9	0	1	2	1	0	0	2	2	3	1	3	1	2	3	2	1	2	6	4			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr13:107863084A>T	uc001vql.2	-	2	1451	c.935T>A	c.(934-936)CTC>CAC	p.L312H		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	312						integral to membrane	binding			skin(1)	1						CTGGGAACAGAGCCAGGCTTT	0.413											OREG0022506	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	41					0	0	0	0	T	107863084	T	T	107863084	3	4	277	1	0	0	0	0	1	0	0	0	5493	304	11	5	449	5	FAM155A	13	107863084	Missense_Mutation	SNP	A	TCGA-D6-6517-01A-11D-1870-08		107863084	7306794	56	52075											
COL4A2	1284	broad.mit.edu	37	chr13	111117869	111117869	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcccggcctcaaaggccaaCgtggtttccctggagacgcc	7	8	11	15	3	1	1	1	0	0	1	3	2	3	1	5	4	1	1	5	4	2	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr13:111117869C>T	uc001vqx.2	+	25	2183	c.1894C>T	c.(1894-1896)CGT>TGT	p.R632C		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	632	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CAAAGGCCAACGTGGTTTCCC	0.632													9	34					0	0	0	0	T	111117869	T	T	111117869	3	4	277	1	0	0	0	0	1	0	0	0	3705	536	19	1	1988	1	COL4A2	13	111117869	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	3254785	111117869	4052009	57	52076											
ZBTB25	7597	broad.mit.edu	37	chr14	64954345	64954345	+	Frame_Shift_Del	DEL	A	-	-																															acatctctcctgcttgatggAaactgggggcttctggtgct																										TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr14:64954345delA	uc001xhf.2	-	3	787	c.604delT	c.(604-606)TCCfs	p.S202fs	ZBTB25_uc001xhc.2_Intron|ZBTB25_uc001xhg.2_Frame_Shift_Del_p.S202fs	NM_006977	NP_008908	P24278	ZBT25_HUMAN	zinc finger protein 46	202						cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		TGCTTGATGGAAACTGGGGGC	0.567													---	---	---								-	64954345	-	-	64954345	7	5	277	1	0	1	0	1	0	0	0	0	17599	246	9	0	707	0	ZBTB25	14	64954345	Frame_Shift_Del	DEL	A	TCGA-D6-6517-01A-11D-1870-08		64954345	42395195	58	52077											
ACYP1	97	broad.mit.edu	37	chr14	75520263	75520263	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtttcaagccattcctgcaTatgacgcaccttggagatgg	9	12	10	10	1	1	2	1	1	0	1	2	3	2	2	3	2	2	3	3	2	2	4			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr14:75520263T>C	uc001xrg.2	-	3	272	c.184A>G	c.(184-186)ATG>GTG	p.M62V	MLH3_uc001xrd.1_5'Flank|MLH3_uc001xre.1_5'Flank|ACYP1_uc001xrf.2_3'UTR	NM_001107	NP_001098	P07311	ACYP1_HUMAN	acylphosphatase 1 isoform a	62	Acylphosphatase-like.				phosphate metabolic process		acylphosphatase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00646)		CATTCCTGCATATGACGCACC	0.468													49	138					0	0	0	0	C	75520263	C	C	75520263	3	2	277	1	0	0	0	0	1	0	0	0	228	1406	49	5	119	5	ACYP1	14	75520263	Missense_Mutation	SNP	T	TCGA-D6-6517-01A-11D-1870-08	10565918	75520263	31829277	59	52078											
MARK3	4140	broad.mit.edu	37	chr14	103958157	103958157	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagttgcttcaacacacagtAtcagtagtgcagccacccca	12	8	7	14	0	2	0	2	0	0	0	2	0	2	0	3	0	4	5	3	0	3	4			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr14:103958157A>G	uc001ymz.3	+	15	2296	c.1630A>G	c.(1630-1632)ATC>GTC	p.I544V	MARK3_uc001ymx.3_Missense_Mutation_p.I544V|MARK3_uc001ymw.3_Missense_Mutation_p.I544V|MARK3_uc001yna.3_Missense_Mutation_p.I528V|MARK3_uc001ymy.3_Missense_Mutation_p.I465V|MARK3_uc010awp.2_Missense_Mutation_p.I567V|MARK3_uc010tyb.1_Missense_Mutation_p.I339V|MARK3_uc010awq.2_Missense_Mutation_p.I126V	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	544							ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)			AACACACAGTATCAGTAGTGC	0.488													11	45					0	0	0	0	G	103958157	G	G	103958157	3	3	277	1	0	0	0	0	1	0	0	0	9367	449	16	5	1688	5	MARK3	14	103958157	Missense_Mutation	SNP	A	TCGA-D6-6517-01A-11D-1870-08	28437894	103958157	3391383	60	52079											
FOXB1	27023	broad.mit.edu	37	chr15	60297484	60297484	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcttcctgcggcgccgcaagCgcttcaaggtgcttaagtcc	6	9	12	14	4	1	0	1	0	0	0	3	0	3	0	3	2	3	4	3	2	3	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr15:60297484C>A	uc002agj.1	+	2	801	c.322C>A	c.(322-324)CGC>AGC	p.R108S	FOXB1_uc010bgh.1_Intron	NM_012182	NP_036314	Q99853	FOXB1_HUMAN	forkhead box B1	108					axon target recognition|cell migration in diencephalon|epithelial cell differentiation involved in mammary gland alveolus development|floor plate development|hypothalamus cell migration|inferior colliculus development|lactation|mammillothalamic axonal tract development|negative regulation of neuron apoptosis|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|telencephalon cell migration|visual learning	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|central_nervous_system(1)	2						GCGCCGCAAGCGCTTCAAGGT	0.706													10	17					6.40141e-05	7.20159e-05	1	0	A	60297484	A	A	60297484	3	1	277	1	0	0	0	0	1	0	0	0	6024	768	27	3	324	3	FOXB1	15	60297484	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08		60297484	42233908	61	52080											
TLN2	83660	broad.mit.edu	37	chr15	62989996	62989996	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcgggcctgagaccttcaacGttggcagcatgccctcgcca	7	7	12	15	3	1	1	1	1	0	1	2	2	1	1	4	2	3	3	4	2	1	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr15:62989996G>A	uc002alb.3	+	12	1402	c.1402G>A	c.(1402-1404)GTT>ATT	p.V468I		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	468					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						GACCTTCAACGTTGGCAGCAT	0.667													17	25					0	0	0	0	A	62989996	A	A	62989996	3	1	277	1	0	0	0	0	1	0	0	0	16014	1145	40	1	1448	1	TLN2	15	62989996	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	2692512	62989996	39541396	62	52081											
SLC38A7	55238	broad.mit.edu	37	chr16	58705074	58705074	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcgtctgcagcactcgcCgccgccgctcccgccccacg	4	4	10	23	7	1	0	0	0	1	0	3	0	2	0	7	0	3	3	7	0	0	0			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr16:58705074C>A	uc002eod.1	-	10	1499	c.1106G>T	c.(1105-1107)CGG>CTG	p.R369L	SLC38A7_uc002eob.1_RNA|SLC38A7_uc002eoc.1_Intron|SLC38A7_uc010vil.1_Missense_Mutation_p.R280L	NM_018231	NP_060701	Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	369					amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						CAGCACTCGCCGCCGCCGCTC	0.667													4	24					0.00909568	0.00982333	1	0	A	58705074	A	A	58705074	3	1	277	1	0	0	0	0	1	0	0	0	14673	652	23	3	294	3	SLC38A7	16	58705074	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08		58705074	31649679	63	52082											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	7	7	13	14	3	3	0	3	0	0	0	4	0	4	0	3	3	3	2	3	3	1	0	rs28934578		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	48					0	0	0	0	T	7578406	T	T	7578406	3	4	277	1	0	0	0	0	1	0	0	0	16448	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08		7578406	73616804	64	52083											
PER1	5187	broad.mit.edu	37	chr17	8047139	8047139	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtggtggcgtgagcgcttGgctttggatcggcagtggtg	3	12	20	6	3	0	1	0	1	0	0	1	2	0	2	0	7	1	3	0	7	0	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:8047139G>A	uc002gkd.2	-	19	2755	c.2517C>T	c.(2515-2517)GCC>GCT	p.A839A	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_Intron	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	839	Nuclear localization signal (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						GTGAGCGCTTGGCTTTGGATC	0.672			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					16	35					0	0	0	0	A	8047139	A	A	8047139	2	1	277	1	0	0	0	0	0	0	0	1	11783	1335	47	4		4	PER1	17	8047139	Silent	SNP	G	TCGA-D6-6517-01A-11D-1870-08	468733	8047139	73148071	65	52084											
HS3ST3B1	9953	broad.mit.edu	37	chr17	14205268	14205268	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcaggccatcatcatcggcGtgaagaagggcggcacgcgg	9	4	16	12	6	2	2	2	1	0	1	3	2	2	2	1	5	0	2	1	5	2	0			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:14205268G>T	uc002goh.1	+	1	763	c.433G>T	c.(433-435)GTG>TTG	p.V145L	MGC12916_uc010vvv.1_5'Flank	NM_006041	NP_006032	Q9Y662	HS3SB_HUMAN	heparan sulfate D-glucosaminyl	145	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	Golgi membrane|integral to plasma membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		CATCATCGGCGTGAAGAAGGG	0.667													4	19					2.56e-06	3.03824e-06	1	0	T	14205268	T	T	14205268	3	4	277	1	0	0	0	0	1	0	0	0	7405	1145	40	3	435	3	HS3ST3B1	17	14205268	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	6158129	14205268	66989942	66	52085											
KRT31	3881	broad.mit.edu	37	chr17	39551520	39551520	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gttgtgctgggcctgcagctCgatctccagggcgttgactg	4	11	15	11	2	1	1	0	1	1	0	3	2	1	1	2	2	3	5	2	2	0	2			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:39551520C>G	uc002hwn.2	-	5	906	c.853G>C	c.(853-855)GAG>CAG	p.E285Q	KRT31_uc010cxn.2_Missense_Mutation_p.E285Q	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	285	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				GCCTGCAGCTCGATCTCCAGG	0.607													14	64					0	0	0	0	G	39551520	G	G	39551520	3	3	277	1	0	0	0	0	1	0	0	0	8506	893	31	3	409	3	KRT31	17	39551520	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	25346252	39551520	41643690	67	52086											
GJC1	10052	broad.mit.edu	37	chr17	42882699	42882699	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaatccgtcgtcggccatCatgcttaggtttgggttggc	5	12	13	11	4	1	0	1	0	0	0	4	1	2	0	3	4	1	3	3	4	2	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:42882699C>A	uc002ihj.2	-	2	998	c.487G>T	c.(487-489)GAT>TAT	p.D163Y	GJC1_uc002ihk.2_Missense_Mutation_p.D163Y|GJC1_uc002ihl.2_Missense_Mutation_p.D163Y|GJC1_uc010czx.2_Missense_Mutation_p.D163Y|GJC1_uc010czy.1_Missense_Mutation_p.D24Y	NM_005497	NP_005488	P36383	CXG1_HUMAN	connexin 45	163	Cytoplasmic (Potential).				cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane					0		Prostate(33;0.0959)				CGTCGGCCATCATGCTTAGGT	0.478													27	127					6.12954e-19	7.88083e-19	1	0	A	42882699	A	A	42882699	3	1	277	1	0	0	0	0	1	0	0	0	6451	826	29	2	707	2	GJC1	17	42882699	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08	3331179	42882699	38312511	68	52087											
HELZ	9931	broad.mit.edu	37	chr17	65174905	65174905	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggtcagcagagaggggaaTttggtatctgataagaaggc	12	9	15	5	0	2	3	1	1	1	2	2	5	2	4	0	5	1	2	0	5	4	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:65174905T>C	uc010wqk.1	-	13	1487	c.1300A>G	c.(1300-1302)ATT>GTT	p.I434V	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.I434V	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GAGAGGGGAATTTGGTATCTG	0.383													5	102					0	0	0	0	C	65174905	C	C	65174905	3	2	277	1	0	0	0	0	1	0	0	0	7088	1493	52	5	4612	5	HELZ	17	65174905	Missense_Mutation	SNP	T	TCGA-D6-6517-01A-11D-1870-08	22292206	65174905	16020305	69	52088											
MC5R	4161	broad.mit.edu	37	chr18	13826449	13826449	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcccggggccagctctgcgCggcagaggaccagcatgcag	7	4	16	14	3	1	1	0	0	1	1	1	2	1	2	3	4	5	4	3	4	0	0			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr18:13826449C>A	uc010xaf.1	+	1	685	c.685C>A	c.(685-687)CGG>AGG	p.R229R		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	229	Cytoplasmic (Potential).			ALPGASSARQRTSM -> LCPGPALRGRGPAW (in Ref. 1).	G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						CAGCTCTGCGCGGCAGAGGAC	0.617													35	137					3.03874e-20	3.95402e-20	1	0	A	13826449	A	A	13826449	2	1	277	1	0	0	0	0	0	0	0	1	9420	759	27	3		3	MC5R	18	13826449	Silent	SNP	C	TCGA-D6-6517-01A-11D-1870-08		13826449	64250799	70	52089											
ZNF99	7652	broad.mit.edu	37	chr19	22940099	22940099	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattcttcacatttgtagggTttctttccagtatgaattat	9	19	6	7	0	3	1	1	1	2	0	4	1	4	1	1	1	0	3	1	1	4	8			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr19:22940099T>G	uc010xrh.1	-	6	2232	c.2232A>C	c.(2230-2232)AAA>AAC	p.K744N		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ATTTGTAGGGTTTCTTTCCAG	0.348													12	55					0	0	0	0	G	22940099	G	G	22940099	3	3	277	1	0	0	0	0	1	0	0	0	18271	1722	60	5	888	5	ZNF99	19	22940099	Missense_Mutation	SNP	T	TCGA-D6-6517-01A-11D-1870-08		22940099	36188884	71	52090											
SIGLEC6	946	broad.mit.edu	37	chr19	52033054	52033054	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggtgaaatctccttcttcTgcagaccctacttgaggcag	9	11	9	12	0	3	3	0	2	3	1	4	3	3	3	2	2	2	2	2	2	2	4			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr19:52033054T>G	uc002pwy.2	-	5	1098	c.936A>C	c.(934-936)GCA>GCC	p.A312A	SIGLEC6_uc002pwz.2_Silent_p.A296A|SIGLEC6_uc002pxa.2_Silent_p.A312A|SIGLEC6_uc010ydb.1_Silent_p.A249A|SIGLEC6_uc010ydc.1_Silent_p.A312A|SIGLEC6_uc010eoz.1_Silent_p.A290A|SIGLEC6_uc010epb.1_Silent_p.A265A|SIGLEC6_uc010epa.1_Silent_p.A301A	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	312	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CTCCTTCTTCTGCAGACCCTA	0.607													14	32					0	0	0	0	G	52033054	G	G	52033054	2	3	277	1	0	0	0	0	0	0	0	1	14377	1567	55	5		5	SIGLEC6	19	52033054	Silent	SNP	T	TCGA-D6-6517-01A-11D-1870-08	29092955	52033054	7095929	72	52091											
MCM8	84515	broad.mit.edu	37	chr20	5974238	5974238	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatgagcaacaggtcaacagCgaaaagatttatttctgctc	15	10	8	8	1	2	2	1	1	1	1	3	3	2	2	0	1	5	2	0	1	6	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr20:5974238C>G	uc002wmi.2	+	18	2704	c.2327C>G	c.(2326-2328)GCG>GGG	p.A776G	MCM8_uc002wmj.2_Missense_Mutation_p.A760G|MCM8_uc002wmk.2_Missense_Mutation_p.A816G|MCM8_uc002wml.2_Missense_Mutation_p.A776G|MCM8_uc010gbp.2_Missense_Mutation_p.A729G|MCM8_uc002wmm.2_Missense_Mutation_p.A314G	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	776					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						AGGTCAACAGCGAAAAGATTT	0.368													18	93					0	0	0	0	G	5974238	G	G	5974238	3	3	277	1	0	0	0	0	1	0	0	0	9446	768	27	3	2393	3	MCM8	20	5974238	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08		5974238	57051282	73	52092											
PKIG	11142	broad.mit.edu	37	chr20	43246985	43246985	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaccagccccagagcagcGatgggaccacctcgtcttga	10	5	11	15	2	1	2	0	1	1	1	2	4	1	3	5	1	4	2	5	1	1	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr20:43246985G>T	uc002xmg.2	+	6	740	c.211G>T	c.(211-213)GAT>TAT	p.D71Y	PKIG_uc002xmh.2_Missense_Mutation_p.D71Y|PKIG_uc002xmi.2_Missense_Mutation_p.D71Y	NM_181805	NP_861521	Q9Y2B9	IPKG_HUMAN	cAMP-dependent protein kinase inhibitor gamma	71							cAMP-dependent protein kinase inhibitor activity|protein binding				0		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.001)|COAD - Colon adenocarcinoma(18;0.00189)			CCAGAGCAGCGATGGGACCAC	0.587													37	132					9.62906e-15	1.20923e-14	1	0	T	43246985	T	T	43246985	3	4	277	1	0	0	0	0	1	0	0	0	12030	1058	37	3	217	3	PKIG	20	43246985	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08	37272747	43246985	19778535	74	52093											
ARFGEF2	10564	broad.mit.edu	37	chr20	47591350	47591350	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtgcctcgtgtccattctCaagtgcatggtggagtggag	7	11	15	8	1	1	0	1	0	1	0	4	3	2	2	2	3	2	1	2	3	1	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr20:47591350C>T	uc002xtx.3	+	13	1865	c.1713C>T	c.(1711-1713)CTC>CTT	p.L571L		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	571					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TGTCCATTCTCAAGTGCATGG	0.507													8	17					0	0	0	0	T	47591350	T	T	47591350	2	4	277	1	0	0	0	0	0	0	0	1	853	813	29	2		2	ARFGEF2	20	47591350	Silent	SNP	C	TCGA-D6-6517-01A-11D-1870-08	4344365	47591350	15434170	75	52094											
SON	6651	broad.mit.edu	37	chr21	34931551	34931551	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaagaaatgtaaacagatcGcacagagtaaagaagatgat	21	7	9	4	1	0	6	0	1	0	5	1	6	0	6	0	0	1	3	0	0	8	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr21:34931551G>A	uc002yse.1	+	5	6386	c.6337G>A	c.(6337-6339)GCA>ACA	p.A2113T	SON_uc002ysc.2_Missense_Mutation_p.A2113T|SON_uc002ysd.2_Missense_Mutation_p.A1104T|SON_uc002ysf.1_Missense_Mutation_p.A141T|SON_uc002ysg.2_Missense_Mutation_p.A1104T	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	2113					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TAAACAGATCGCACAGAGTAA	0.308													12	42					0	0	0	0	A	34931551	A	A	34931551	3	1	277	1	0	0	0	0	1	0	0	0	14990	1087	38	1	6355	1	SON	21	34931551	Missense_Mutation	SNP	G	TCGA-D6-6517-01A-11D-1870-08		34931551	13198344	76	52095											
GAL3ST1	9514	broad.mit.edu	37	chr22	30951241	30951241	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcgcgggccatgcgctccCgcccgaaggcctccaccttg	4	6	11	20	5	0	0	0	0	0	0	3	1	2	0	7	2	1	1	7	2	1	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr22:30951241C>A	uc003aig.1	-	4	1111	c.971G>T	c.(970-972)CGG>CTG	p.R324L	GAL3ST1_uc003aih.1_Missense_Mutation_p.R324L|GAL3ST1_uc003aii.1_Missense_Mutation_p.R324L|GAL3ST1_uc010gvz.1_Missense_Mutation_p.R324L	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	324	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CATGCGCTCCCGCCCGAAGGC	0.711													5	10					3.59834e-05	4.09074e-05	1	0	A	30951241	A	A	30951241	3	1	277	1	0	0	0	0	1	0	0	0	6232	652	23	3	304	3	GAL3ST1	22	30951241	Missense_Mutation	SNP	C	TCGA-D6-6517-01A-11D-1870-08		30951241	20353325	77	52096											
TUBGCP6	85378	broad.mit.edu	37	chr22	50664505	50664505	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcagcagagcttcagcaggtTaatggtctttccgcagacgt	9	10	12	10	2	2	2	1	0	1	2	3	2	3	2	1	2	3	6	1	2	1	3			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr22:50664505T>A	uc003bkb.1	-	9	2319	c.1807A>T	c.(1807-1809)AAC>TAC	p.N603Y	TUBGCP6_uc010har.1_Missense_Mutation_p.N603Y|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'Flank|TUBGCP6_uc003bkd.1_5'UTR	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	603					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TTCAGCAGGTTAATGGTCTTT	0.582													6	140					0	0	0	0	A	50664505	A	A	50664505	3	1	277	1	0	0	0	0	1	0	0	0	16838	1754	61	5	3720	5	TUBGCP6	22	50664505	Missense_Mutation	SNP	T	TCGA-D6-6517-01A-11D-1870-08	19713264	50664505	640061	78	52097											
USP9X	8239	broad.mit.edu	37	chrX	41088557	41088563	+	Frame_Shift_Del	DEL	CACAATC	-	-																															gaccgagatgggctgtttgaCacaatccagcgctctaagaa																										TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chrX:41088557_41088563delCACAATC	uc004dfb.2	+	42	7746_7752	c.7113_7119delCACAATC	c.(7111-7119)GACACAATCfs	p.D2371fs	USP9X_uc004dfc.2_Frame_Shift_Del_p.D2371fs	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2371_2373					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GGCTGTTTGACACAATCCAGCGCTCTA	0.353													---	---	---								-	41088563	-	-	41088557	7	5	277	1	0	1	0	1	0	0	0	0	17158	477	17	0	7275	0	USP9X	23	41088557	Frame_Shift_Del	DEL	CACAATC	TCGA-D6-6517-01A-11D-1870-08		41088557	114182003	79	52098											
MAOA	4128	broad.mit.edu	37	chrX	43590580	43590580	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaccatcctgtcactcaCgttgaccagtcaagtgacaa	12	9	7	13	1	3	3	3	3	0	0	4	3	4	3	3	0	1	1	3	0	3	1			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chrX:43590580C>T	uc004dfy.2	+	7	919	c.738C>T	c.(736-738)CAC>CAT	p.H246H	MAOA_uc011mkw.1_Silent_p.H113H	NM_000240	NP_000231	P21397	AOFA_HUMAN	monoamine oxidase A	246	Cytoplasmic.				behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			breast(2)|ovary(1)	3					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	CTGTCACTCACGTTGACCAGT	0.453													22	14					0	0	0	0	T	43590580	T	T	43590580	2	4	277	1	0	0	0	0	0	0	0	1	9278	535	19	1		1	MAOA	23	43590580	Silent	SNP	C	TCGA-D6-6517-01A-11D-1870-08	2502023	43590580	111679980	80	52099											
BCORL1	63035	broad.mit.edu	37	chrX	129147297	129147297	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcaactctgggaactggagtCcctgtggaggggaccctgcc	7	7	15	12	0	1	0	0	0	1	0	2	4	2	4	3	5	3	1	3	5	2	0			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chrX:129147297C>A	uc004evb.1	+	4	663	c.549C>A	c.(547-549)GTC>GTA	p.V183V	BCORL1_uc010nrd.1_Silent_p.V85V	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	183					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						GAACTGGAGTCCCTGTGGAGG	0.577													9	30					0.000978159	0.00107797	1	0	A	129147297	A	A	129147297	2	1	277	1	0	0	0	0	0	0	0	1	1389	842	30	2		2	BCORL1	23	129147297	Silent	SNP	C	TCGA-D6-6517-01A-11D-1870-08	85556717	129147297	26123263	81	52100											
APITD1	378708	broad.mit.edu	37	chr1	10494001	10494001	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agaccattgcggccatttcgGagctgactttccgacagtgt	8	11	11	11	3	0	2	0	1	0	1	2	4	1	3	3	2	2	1	3	2	0	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:10494001G>A	uc001are.2	+	2	570	c.154G>A	c.(154-156)GAG>AAG	p.E52K	APITD1_uc001arf.2_Missense_Mutation_p.E52K|APITD1_uc001arg.2_Missense_Mutation_p.G131E|APITD1_uc001arh.2_Missense_Mutation_p.E13K	NM_199294	NP_954988	Q8N2Z9	CENPS_HUMAN	apoptosis-inducing, TAF9-like domain 1 isoform	52					DNA repair|mitotic prometaphase|transcription initiation, DNA-dependent	chromosome, centromeric region|cytosol|Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		GGCCATTTCGGAGCTGACTTT	0.522													43	125					0	0	0	0	A	10494001	A	A	10494001	3	1	278	1	0	0	0	0	1	0	0	0	775	1175	41	2	160	2	APITD1	1	10494001	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08		10494001	238756620	1	52101											
TAS1R2	80834	broad.mit.edu	37	chr1	19166514	19166514	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtggtgggactgaggcccGtggccagcatgccaattacc	7	7	16	11	1	0	1	0	1	0	0	0	2	0	2	4	5	3	1	4	5	2	1	rs149445409		TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:19166514G>A	uc001bba.1	-	6	2100	c.2099C>T	c.(2098-2100)ACG>ATG	p.T700M		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	700	Helical; Name=4; (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	ACTGAGGCCCGTGGCCAGCAT	0.562													40	77					0	0	0	0	A	19166514	A	A	19166514	3	1	278	1	0	0	0	0	1	0	0	0	15629	1145	40	1	424	1	TAS1R2	1	19166514	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	8672513	19166514	230084107	2	52102											
LPAR3	23566	broad.mit.edu	37	chr1	85331609	85331609	+	Frame_Shift_Del	DEL	G	-	-																															aaattagccaacaggtagtaGaaggggaaatgaaattttct																										TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:85331609delG	uc001dkl.2	-	1	234	c.195delC	c.(193-195)TTCfs	p.F65fs	LPAR3_uc009wcj.1_Frame_Shift_Del_p.F65fs	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	65	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						ACAGGTAGTAGAAGGGGAAAT	0.393													---	---	---								-	85331609	-	-	85331609	7	5	278	1	0	1	0	1	0	0	0	0	8956	933	33	0	874	0	LPAR3	1	85331609	Frame_Shift_Del	DEL	G	TCGA-D6-6823-01A-11D-1912-08	66165095	85331609	163919012	3	52103											
LPPR4	9890	broad.mit.edu	37	chr1	99771647	99771647	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaagaataagaatgaaagtcGaaagttgtccttgcaagtta	17	10	10	4	1	0	3	0	1	0	2	2	5	1	3	1	0	1	3	1	0	8	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:99771647G>A	uc001dse.2	+	7	1479	c.1373G>A	c.(1372-1374)CGA>CAA	p.R458Q	LPPR4_uc010oue.1_Missense_Mutation_p.R400Q	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	458							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AATGAAAGTCGAAAGTTGTCC	0.493													27	67					0	0	0	0	A	99771647	A	A	99771647	3	1	278	1	0	0	0	0	1	0	0	0	8977	1058	37	1	1399	1	LPPR4	1	99771647	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	14440038	99771647	149478974	4	52104											
CDC14A	8556	broad.mit.edu	37	chr1	100819350	100819350	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgctactttaaggaatagaCcaaaaagcacagtaaatacc	18	9	6	8	0	0	1	0	0	0	1	0	2	0	2	2	1	4	3	2	1	9	7			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:100819350C>A	uc001dtg.3	+	2	570	c.82C>A	c.(82-84)CCA>ACA	p.P28T	CDC14A_uc009web.2_Intron|CDC14A_uc010oui.1_5'UTR|CDC14A_uc001dte.3_Missense_Mutation_p.P28T|CDC14A_uc001dtf.2_Missense_Mutation_p.P28T|CDC14A_uc009wed.1_5'UTR|CDC14A_uc009wee.2_Missense_Mutation_p.P28T|CDC14A_uc009wec.1_Missense_Mutation_p.P28T	NM_003672	NP_003663	Q9UNH5	CC14A_HUMAN	CDC14 homolog A isoform 1	28	A.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		AAGGAATAGACCAAAAAGCAC	0.358													7	23					0.000274275	0.00137138	1	0	A	100819350	A	A	100819350	3	1	278	1	0	0	0	0	1	0	0	0	3071	507	18	4	88	4	CDC14A	1	100819350	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	1047703	100819350	148431271	5	52105											
C1orf125	126859	broad.mit.edu	37	chr1	179401427	179401427	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagacattttatcccctaatAagggaaatatatttaattca	17	14	4	6	0	1	1	1	0	0	1	2	2	2	2	2	1	0	0	2	1	8	9			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:179401427A>C	uc001gmo.2	+	15	1640	c.1513A>C	c.(1513-1515)AAG>CAG	p.K505Q	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Missense_Mutation_p.K293Q|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.K505Q	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	505											0						ATCCCCTAATAAGGGAAATAT	0.308													4	11					0	0	0	0	C	179401427	C	C	179401427	3	2	278	1	0	0	0	0	1	0	0	0	2002	363	13	5	1567	5	C1orf125	1	179401427	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	78582077	179401427	69849194	6	52106											
RGS2	5997	broad.mit.edu	37	chr1	192780144	192780144	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attcagggcttttttaaagtCggaattctgtgaagaaaata	14	14	9	4	1	2	2	1	1	1	1	3	3	2	3	0	2	0	1	0	2	7	6			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:192780144C>T	uc001gsl.2	+	4	341	c.308C>T	c.(307-309)TCG>TTG	p.S103L		NM_002923	NP_002914	P41220	RGS2_HUMAN	regulator of G-protein signaling 2	103	RGS.|Necessary to inhibit protein synthesis.				cell cycle|negative regulation of cardiac muscle hypertrophy|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of MAP kinase activity|negative regulation of phospholipase activity|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|regulation of translation|relaxation of cardiac muscle	cytosol|internal side of plasma membrane|mitochondrion|nucleolus	calmodulin binding|GTPase activator activity|signal transducer activity				0						TTTTTAAAGTCGGAATTCTGT	0.398													36	88					0	0	0	0	T	192780144	T	T	192780144	3	4	278	1	0	0	0	0	1	0	0	0	13367	893	31	1	322	1	RGS2	1	192780144	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	13378717	192780144	56470477	7	52107											
PFKFB2	5208	broad.mit.edu	37	chr1	207240960	207240960	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaatatccacgtccagcctcGcaccatttacctttgccggc	8	10	7	16	3	0	0	0	0	0	0	3	1	2	0	6	1	3	1	6	1	3	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:207240960G>A	uc001hfg.2	+	9	858	c.749G>A	c.(748-750)CGC>CAC	p.R250H	PFKFB2_uc010psc.1_Missense_Mutation_p.R152H|PFKFB2_uc001hfh.2_Missense_Mutation_p.R250H|PFKFB2_uc009xcc.2_Missense_Mutation_p.R208H|PFKFB2_uc010psd.1_Missense_Mutation_p.R64H	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	250	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					GTCCAGCCTCGCACCATTTAC	0.507													50	114					0	0	0	0	A	207240960	A	A	207240960	3	1	278	1	0	0	0	0	1	0	0	0	11816	1087	38	1	779	1	PFKFB2	1	207240960	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	14460816	207240960	42009661	8	52108											
KCNK2	3776	broad.mit.edu	37	chr1	215408401	215408401	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagggatgtcttgcctccCttactgaagactgagagtat	10	11	12	8	0	1	4	0	2	1	3	2	7	2	5	2	1	2	1	2	1	3	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:215408401C>T	uc001hkq.2	+	7	1363	c.1194C>T	c.(1192-1194)CCC>CCT	p.P398P	KCNK2_uc001hko.2_Silent_p.P394P|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc001hkr.3_Silent_p.P383P	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	398	Cytoplasmic (Potential).|Essential for chloroform and halothane sensitivity (By similarity).|Required for basal channel activity (By similarity).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TCTTGCCTCCCTTACTGAAGA	0.493													17	37					0	0	0	0	T	215408401	T	T	215408401	2	4	278	1	0	0	0	0	0	0	0	1	8105	668	24	4		4	KCNK2	1	215408401	Silent	SNP	C	TCGA-D6-6823-01A-11D-1912-08	8167441	215408401	33842220	9	52109											
DISC1	27185	broad.mit.edu	37	chr1	231830106	231830106	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggtccccccaacccctcctgGctctcacagtgcctttacct	5	10	6	20	0	1	0	1	0	1	0	4	0	3	0	8	2	3	1	8	2	2	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:231830106G>T	uc001huz.2	+	2	655	c.602G>T	c.(601-603)GGC>GTC	p.G201V	TSNAX-DISC1_uc010pwe.1_Missense_Mutation_p.G156V|TSNAX-DISC1_uc010pwf.1_Missense_Mutation_p.G156V|TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.G190V|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.G156V|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.G156V|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.G190V|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.G190V|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwo.1_Missense_Mutation_p.G201V|DISC1_uc010pwp.1_Missense_Mutation_p.G201V|DISC1_uc010pwq.1_Missense_Mutation_p.G201V|DISC1_uc010pwr.1_Missense_Mutation_p.G201V|DISC1_uc010pws.1_Missense_Mutation_p.G201V|DISC1_uc010pwt.1_Missense_Mutation_p.G201V|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.G201V|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.G201V|DISC1_uc010pxb.1_Missense_Mutation_p.G201V|DISC1_uc010pxc.1_Missense_Mutation_p.G201V|DISC1_uc010pxd.1_5'UTR|DISC1_uc010pxe.1_Missense_Mutation_p.G201V|DISC1_uc009xfr.2_Missense_Mutation_p.G156V|DISC1_uc010pxf.1_Missense_Mutation_p.G201V|DISC1_uc010pxg.1_Missense_Mutation_p.G201V|DISC1_uc010pxh.1_Missense_Mutation_p.G201V|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_5'UTR|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.G201V|DISC1_uc010pxn.1_5'UTR|DISC1_uc001hva.2_Missense_Mutation_p.G201V|DISC1_uc010pwm.1_Missense_Mutation_p.G201V|DISC1_uc001hux.1_Missense_Mutation_p.G201V|DISC1_uc001hvc.3_Missense_Mutation_p.G201V|DISC1_uc010pwn.1_Missense_Mutation_p.G201V	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	201	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				ACCCCTCCTGGCTCTCACAGT	0.612													9	66					7.48243e-07	3.85125e-06	1	0	T	231830106	T	T	231830106	3	4	278	1	0	0	0	0	1	0	0	0	4560	1203	42	4	608	4	DISC1	1	231830106	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	16421705	231830106	17420515	10	52110											
RGS7	6000	broad.mit.edu	37	chr1	240939491	240939491	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actgagcaaggcttgttaacCtcttggacgtgagagatttc	10	12	11	8	1	1	3	0	2	1	1	2	5	1	4	1	2	2	3	1	2	2	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr1:240939491C>T	uc001hyv.2	-	18	1766	c.1436G>A	c.(1435-1437)AGG>AAG	p.R479K	RGS7_uc010pyh.1_Intron|RGS7_uc010pyj.1_3'UTR|RGS7_uc001hyu.2_3'UTR|RGS7_uc009xgn.1_3'UTR|RGS7_uc001hyw.2_Missense_Mutation_p.R461K|RGS7_uc010pyi.1_RNA|RGS7_uc001hyt.2_3'UTR	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	Error:Variant_position_missing_in_P49802_after_alignment					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GCTTGTTAACCTCTTGGACGT	0.403													4	55					0	0	0	0	T	240939491	T	T	240939491	3	4	278	1	0	0	0	0	1	0	0	0	13375	681	24	4	31	4	RGS7	1	240939491	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	9109385	240939491	8311130	11	52111											
CTNNA2	1496	broad.mit.edu	37	chr2	80782950	80782950	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacatcatcaatgctgagaTggagaactatgaagctgggg	14	8	12	7	0	2	3	2	2	0	2	2	5	2	3	0	3	3	2	0	3	4	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:80782950T>C	uc010ysh.1	+	11	1678	c.1673T>C	c.(1672-1674)ATG>ACG	p.M558T	CTNNA2_uc010yse.1_Missense_Mutation_p.M558T|CTNNA2_uc010ysf.1_Missense_Mutation_p.M558T|CTNNA2_uc010ysg.1_Missense_Mutation_p.M558T|CTNNA2_uc010ysi.1_Missense_Mutation_p.M190T	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	558					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AATGCTGAGATGGAGAACTAT	0.512													10	79					0	0	0	0	C	80782950	C	C	80782950	3	2	278	1	0	0	0	0	1	0	0	0	4030	1464	51	5	1507	5	CTNNA2	2	80782950	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08		80782950	162416423	12	52112											
GCG	2641	broad.mit.edu	37	chr2	163005678	163005678	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataatccagccacaaagtaaAtgcttttcatttctgctgtc	12	14	5	10	0	2	0	1	0	1	0	4	0	3	0	2	0	3	3	2	0	4	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:163005678A>G	uc002ucc.2	-	2	110	c.11T>C	c.(10-12)ATT>ACT	p.I4T		NM_002054	NP_002045	P01275	GLUC_HUMAN	glucagon preproprotein	4					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity				0					Exenatide(DB01276)|Phentolamine(DB00692)	CACAAAGTAAATGCTTTTCAT	0.433													59	114					0	0	0	0	G	163005678	G	G	163005678	3	3	278	1	0	0	0	0	1	0	0	0	6325	101	4	5	551	5	GCG	2	163005678	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	82222728	163005678	80193695	13	52113											
LRP2	4036	broad.mit.edu	37	chr2	170134277	170134277	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgaattccatcataagttaCagtttcaatgtaatcaaacc	15	14	4	8	0	3	1	3	1	0	0	4	1	4	1	2	0	2	3	2	0	6	6			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:170134277C>A	uc002ues.2	-	13	1963	c.1750G>T	c.(1750-1752)GTA>TTA	p.V584L	LRP2_uc010zdf.1_Intron	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	584	LDL-receptor class B 4.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCATAAGTTACAGTTTCAATG	0.388													25	43					4.26978e-12	2.35342e-11	1	0	A	170134277	A	A	170134277	3	1	278	1	0	0	0	0	1	0	0	0	9006	478	17	4	12485	4	LRP2	2	170134277	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	7128599	170134277	73065096	14	52114											
ARPC2	10109	broad.mit.edu	37	chr2	219099116	219099116	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtttcttggtaaatccagaAtcaggtatgtagtcatgtga	12	14	10	5	0	3	2	2	1	1	1	4	2	4	2	1	2	0	4	1	2	5	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:219099116A>G	uc002vhd.2	+	5	376	c.264A>G	c.(262-264)GAA>GAG	p.E88E	ARPC2_uc002vhe.2_Silent_p.E88E|ARPC2_uc002vhf.2_5'Flank	NM_152862	NP_690601	O15144	ARPC2_HUMAN	actin related protein 2/3 complex subunit 2	88					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		TAAATCCAGAATCAGGTATGT	0.328													19	45					0	0	0	0	G	219099116	G	G	219099116	2	3	278	1	0	0	0	0	0	0	0	1	973	98	4	5		5	ARPC2	2	219099116	Silent	SNP	A	TCGA-D6-6823-01A-11D-1912-08	48964839	219099116	24100257	15	52115											
ACSL3	2181	broad.mit.edu	37	chr2	223773571	223773571	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attcttttatattttatacaTtttctaatatcactttatac	12	23	0	6	0	3	0	1	0	2	0	3	0	3	0	0	0	2	0	0	0	8	14			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:223773571T>A	uc002vni.2	+	4	532	c.81T>A	c.(79-81)CAT>CAA	p.H27Q	ACSL3_uc002vnj.2_Missense_Mutation_p.H27Q	NM_004457	NP_004448	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	27	Helical; Signal-anchor for type III membrane protein; (Potential).				long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			ovary(2)	2		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	ATTTTATACATTTTCTAATAT	0.289			T	ETV1	prostate								19	39					0	0	0	0	A	223773571	A	A	223773571	3	1	278	1	0	0	0	0	1	0	0	0	178	1490	52	5	83	5	ACSL3	2	223773571	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08	4674455	223773571	19425802	16	52116											
DGKD	8527	broad.mit.edu	37	chr2	234346041	234346041	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggttcacacatcgtgtaaaGaatccttgctgaccaagtgc	12	10	9	10	1	1	2	1	1	0	1	3	2	2	2	2	1	2	3	2	1	4	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:234346041G>T	uc002vui.1	+	8	850	c.838G>T	c.(838-840)GAA>TAA	p.E280*	DGKD_uc002vuj.1_Nonsense_Mutation_p.E236*|DGKD_uc010fyh.1_Nonsense_Mutation_p.E147*|DGKD_uc010fyi.1_5'Flank|DGKD_uc002vuk.1_Nonsense_Mutation_p.E147*	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	280	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	ATCGTGTAAAGAATCCTTGCT	0.542													11	22					0.000978159	0.00478819	1	0	T	234346041	T	T	234346041	4	4	278	1	0	0	0	0	0	1	0	0	4489	943	33	2	892	2	DGKD	2	234346041	Nonsense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	10572470	234346041	8853332	17	52117											
LRRFIP1	9208	broad.mit.edu	37	chr2	238672160	238672160	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taacgtatcagaacacagatTtaagtgaaattaaggaagaa	20	9	8	4	1	1	4	1	1	0	3	1	5	1	5	0	1	2	1	0	1	8	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr2:238672160T>G	uc002vxe.2	+	11	2096	c.1804T>G	c.(1804-1806)TTA>GTA	p.L602V	LRRFIP1_uc002vxc.2_Intron|LRRFIP1_uc010znm.1_Intron|LRRFIP1_uc002vxd.2_Missense_Mutation_p.L578V|LRRFIP1_uc002vxf.2_Missense_Mutation_p.L546V	NM_001137552	NP_001131024	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting	602					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			breast(3)	3		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		GAACACAGATTTAAGTGAAAT	0.318													5	11					0	0	0	0	G	238672160	G	G	238672160	3	3	278	1	0	0	0	0	1	0	0	0	9077	1838	64	5	2522	5	LRRFIP1	2	238672160	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08	4326119	238672160	4527213	18	52118											
CCR8	1237	broad.mit.edu	37	chr3	39374725	39374725	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgaaccctgttatctatgcTtttgttggggagaagttcaa	9	15	11	6	0	2	2	1	1	1	1	2	3	2	2	1	2	2	4	1	2	5	6			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:39374725T>G	uc010hhr.2	+	2	1041	c.903T>G	c.(901-903)GCT>GCG	p.A301A	CCR8_uc003cjm.2_Silent_p.A218A	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	301	Helical; Name=7; (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		TTATCTATGCTTTTGTTGGGG	0.423													20	27					0	0	0	0	G	39374725	G	G	39374725	2	3	278	1	0	0	0	0	0	0	0	1	2962	1596	56	5		5	CCR8	3	39374725	Silent	SNP	T	TCGA-D6-6823-01A-11D-1912-08		39374725	158647705	19	52119											
RBM6	10180	broad.mit.edu	37	chr3	50095370	50095370	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttctcgaagggaagggccaActttccgaagagaccgagag	12	6	13	10	3	1	2	0	0	1	2	3	7	2	3	3	2	1	0	3	2	4	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:50095370A>T	uc003cyc.2	+	9	2036	c.1903A>T	c.(1903-1905)ACT>TCT	p.T635S	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_Missense_Mutation_p.T154S|RBM6_uc003cyd.2_Missense_Mutation_p.T113S|RBM6_uc003cye.2_Missense_Mutation_p.T113S|RBM6_uc011bdi.1_5'UTR|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	635					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		GGAAGGGCCAACTTTCCGAAG	0.517													6	10					0	0	0	0	T	50095370	T	T	50095370	3	4	278	1	0	0	0	0	1	0	0	0	13209	43	2	5	1933	5	RBM6	3	50095370	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	10720645	50095370	147927060	20	52120											
FOXP1	27086	broad.mit.edu	37	chr3	71026794	71026794	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atactgtgttatttacttacCtgcctaattaaagatgcata	13	16	5	7	0	0	1	0	0	0	1	0	1	0	1	2	0	5	2	2	0	8	8			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:71026794C>G	uc003dol.2	-	12	1751	c.1428G>C	c.(1426-1428)CAG>CAC	p.Q476H	FOXP1_uc003dom.2_Missense_Mutation_p.Q400H|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Missense_Mutation_p.Q475H|FOXP1_uc003dop.2_Missense_Mutation_p.Q476H|FOXP1_uc003doq.1_Missense_Mutation_p.Q475H|FOXP1_uc003doi.2_Missense_Mutation_p.Q376H|FOXP1_uc003doj.2_Missense_Mutation_p.Q376H|FOXP1_uc003dok.2_Missense_Mutation_p.Q289H|FOXP1_uc003dor.1_Missense_Mutation_p.Q253H	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	476	Fork-head.				cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		ATTTACTTACCTGCCTAATTA	0.323			T	PAX5	ALL								10	48					0	0	0	0	G	71026794	G	G	71026794	3	3	278	1	0	0	0	0	1	0	0	0	6060	695	24	4	629	4	FOXP1	3	71026794	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	20931424	71026794	126995636	21	52121											
ALG1L2	644974	broad.mit.edu	37	chr3	129811047	129811047	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggccagccctgctggtcAgcagcacaagctggacaggt	9	5	14	13	1	1	0	1	0	0	0	1	1	1	1	2	4	6	4	2	4	1	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:129811047A>T	uc011bld.1	+	3	421	c.235A>T	c.(235-237)AGC>TGC	p.S79C	ALG1L2_uc010hth.2_RNA	NM_001136152	NP_001129624	C9J202	AG1L2_HUMAN	asparagine-linked glycosylation 1-like 2	79					biosynthetic process		transferase activity, transferring glycosyl groups				0						CCTGCTGGTCAGCAGCACAAG	0.642													3	9					0	0	0	0	T	129811047	T	T	129811047	3	4	278	1	0	0	0	0	1	0	0	0	518	188	7	5	245	5	ALG1L2	3	129811047	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	58784253	129811047	68211383	22	52122											
TXNDC6	347736	broad.mit.edu	37	chr3	138037035	138037035	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacttccctctgtacttttcGaggacatcaagacgatctgc	9	12	7	13	2	3	1	1	0	2	1	5	4	4	2	1	1	2	1	1	1	2	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:138037035G>A	uc003esg.2	-	4	250	c.222C>T	c.(220-222)CTC>CTT	p.L74L	TXNDC6_uc003esd.1_RNA|TXNDC6_uc010huf.1_Intron|TXNDC6_uc003ese.1_Silent_p.L52L	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	74	Thioredoxin.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						TGTACTTTTCGAGGACATCAA	0.458													46	32					0	0	0	0	A	138037035	A	A	138037035	2	1	278	1	0	0	0	0	0	0	0	1	16868	1045	37	1		1	TXNDC6	3	138037035	Silent	SNP	G	TCGA-D6-6823-01A-11D-1912-08	8225988	138037035	59985395	23	52123											
MUC4	4585	broad.mit.edu	37	chr3	195498614	195498614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtcccggcctgtgaagcctGttgggagtgggttggggtag	4	10	20	7	1	0	1	0	1	0	0	1	2	1	2	3	6	1	3	3	6	2	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr3:195498614G>A	uc011bto.1	-	6	13227	c.12767C>T	c.(12766-12768)ACA>ATA	p.T4256I	MUC4_uc003fuz.2_Nonsense_Mutation_p.Q64*|MUC4_uc003fva.2_Intron|MUC4_uc003fvb.2_Intron|MUC4_uc003fvc.2_Intron|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_5'UTR|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_5'UTR|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_5'UTR|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Missense_Mutation_p.T125I|MUC4_uc011btk.1_5'UTR|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Missense_Mutation_p.T125I|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Missense_Mutation_p.T148I|MUC4_uc003fvp.2_Missense_Mutation_p.T97I|MUC4_uc010hzu.1_Missense_Mutation_p.T996I	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1141					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTGAAGCCTGTTGGGAGTGG	0.557													30	85					0	0	0	0	A	195498614	A	A	195498614	3	1	278	1	0	0	0	0	1	0	0	0	10031	1377	48	4	3171	4	MUC4	3	195498614	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	57461579	195498614	2523816	24	52124											
KIAA0232	9778	broad.mit.edu	37	chr4	6864910	6864910	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attcattcttggaggagtttAtggagaactcaaaaccttca	13	13	8	7	0	4	1	3	0	1	1	4	4	4	3	1	3	2	1	1	3	4	6			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:6864910A>G	uc003gjr.3	+	7	3264	c.2801A>G	c.(2800-2802)TAT>TGT	p.Y934C	KIAA0232_uc003gjq.3_Missense_Mutation_p.Y934C	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	934							ATP binding			ovary(2)	2						GGAGGAGTTTATGGAGAACTC	0.443													10	37					0	0	0	0	G	6864910	G	G	6864910	3	3	278	1	0	0	0	0	1	0	0	0	8202	449	16	5	2819	5	KIAA0232	4	6864910	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08		6864910	184289366	25	52125											
AGPAT9	84803	broad.mit.edu	37	chr4	84519214	84519214	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttctcagtataaccctcAgttcggtgatgcattttgga	8	17	8	8	1	2	1	2	1	1	0	4	2	2	2	1	2	2	3	1	2	2	7			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:84519214A>T	uc003how.2	+	11	1225	c.1007A>T	c.(1006-1008)CAG>CTG	p.Q336L	AGPAT9_uc003hox.2_Missense_Mutation_p.Q336L|AGPAT9_uc003hoy.2_Missense_Mutation_p.Q336L	NM_032717	NP_116106	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	336					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			skin(1)	1		Hepatocellular(203;0.114)				TATAACCCTCAGTTCGGTGAT	0.433													16	53					0	0	0	0	T	84519214	T	T	84519214	3	4	278	1	0	0	0	0	1	0	0	0	392	188	7	5	1045	5	AGPAT9	4	84519214	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	77654304	84519214	106635062	26	52126											
UNC5C	8633	broad.mit.edu	37	chr4	96222757	96222757	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttattgtacaatgactcacAtgcaatgcgcacatacgcct	12	11	6	12	2	1	1	1	1	0	0	1	1	1	1	1	0	4	3	1	0	5	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:96222757A>T	uc003htp.1	-	3	644	c.490T>A	c.(490-492)TAT>AAT	p.Y164N	UNC5C_uc010ilc.1_Missense_Mutation_p.Y164N|UNC5C_uc003htq.2_Missense_Mutation_p.Y164N	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	164	Extracellular (Potential).|Ig-like C2-type.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		AATGACTCACATGCAATGCGC	0.483													13	60					0	0	0	0	T	96222757	T	T	96222757	3	4	278	1	0	0	0	0	1	0	0	0	17061	231	8	5	2361	5	UNC5C	4	96222757	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	11703543	96222757	94931519	27	52127											
C4orf31	79625	broad.mit.edu	37	chr4	121958534	121958534	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caaagaggcagtggggcttgGtttccaggccaaagtgaccg	10	7	15	9	1	0	2	0	1	0	1	1	2	1	2	3	5	0	3	3	5	2	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:121958534G>T	uc003idq.1	-	4	1119	c.592C>A	c.(592-594)CCA>ACA	p.P198T		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	198											0						GTGGGGCTTGGTTTCCAGGCC	0.493													16	115					3.32936e-07	1.73922e-06	1	0	T	121958534	T	T	121958534	3	4	278	1	0	0	0	0	1	0	0	0	2271	1261	44	4	1118	4	C4orf31	4	121958534	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	25735777	121958534	69195742	28	52128											
TNIP3	79931	broad.mit.edu	37	chr4	122063056	122063056	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aaaccaagccgcagttacagGgtgggcaatacatctgagga	14	6	12	9	1	1	1	0	1	1	0	1	2	1	2	2	3	4	3	2	3	5	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:122063056G>T	uc010ing.2	-	9	996	c.800C>A	c.(799-801)CCC>CAC	p.P267H	TNIP3_uc010inh.2_Missense_Mutation_p.P267H|TNIP3_uc011cgj.1_Missense_Mutation_p.P325H	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	267										ovary(1)	1						GCAGTTACAGGGTGGGCAATA	0.507													7	40					7.48243e-07	3.85125e-06	1	0	T	122063056	T	T	122063056	3	4	278	1	0	0	0	0	1	0	0	0	16382	1232	43	4	189	4	TNIP3	4	122063056	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	104522	122063056	69091220	29	52129											
PLK4	10733	broad.mit.edu	37	chr4	128814677	128814677	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttttgaaatagggtcatcgtAtttgtttagcactggaatcc	10	16	9	6	1	1	1	1	1	0	0	3	2	2	2	1	2	1	3	1	2	5	7			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr4:128814677A>G	uc003ifo.2	+	12	2577	c.2332A>G	c.(2332-2334)ATT>GTT	p.I778V	PLK4_uc011cgs.1_Missense_Mutation_p.I746V|PLK4_uc011cgt.1_Missense_Mutation_p.I737V	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	778					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GGGTCATCGTATTTGTTTAGC	0.338													11	50					0	0	0	0	G	128814677	G	G	128814677	3	3	278	1	0	0	0	0	1	0	0	0	12153	449	16	5	2378	5	PLK4	4	128814677	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	6751621	128814677	62339599	30	52130											
ROPN1L	83853	broad.mit.edu	37	chr5	10448390	10448390	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctatttttcagctctgtcGagaggagatccacttcctgt	8	14	9	10	1	2	2	1	0	1	2	5	4	4	2	2	1	2	2	2	1	1	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr5:10448390G>A	uc003jex.3	+	2	421	c.150G>A	c.(148-150)TCG>TCA	p.S50S		NM_031916	NP_114122	Q96C74	ROP1L_HUMAN	ropporin 1-like	50					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			ovary(1)	1						CAGCTCTGTCGAGAGGAGATC	0.423													24	48					0	0	0	0	A	10448390	A	A	10448390	2	1	278	1	0	0	0	0	0	0	0	1	13590	1045	37	1		1	ROPN1L	5	10448390	Silent	SNP	G	TCGA-D6-6823-01A-11D-1912-08		10448390	170466870	31	52131											
LIFR	3977	broad.mit.edu	37	chr5	38493875	38493875	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccatcccaacaacttgttctAttttgagatcatcttcaata	12	15	3	11	0	4	1	2	1	2	1	5	2	5	1	2	0	2	1	2	0	5	7			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr5:38493875A>G	uc010ive.1	-	14	2230	c.1898T>C	c.(1897-1899)ATA>ACA	p.I633T	LIFR_uc003jli.2_Missense_Mutation_p.I633T	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	633	Fibronectin type-III 5.|Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					AACTTGTTCTATTTTGAGATC	0.383			T	PLAG1	salivary adenoma								20	34					0	0	0	0	G	38493875	G	G	38493875	3	3	278	1	0	0	0	0	1	0	0	0	8821	449	16	5	1423	5	LIFR	5	38493875	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	28045485	38493875	142421385	32	52132											
PCDHB5	26167	broad.mit.edu	37	chr5	140517214	140517214	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gcccgagggcccctttccagGgcatctggtggacgtgagcg	5	7	16	13	3	1	1	0	1	1	0	2	3	2	2	4	4	1	1	4	4	0	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr5:140517214G>C	uc003liq.2	+	1	2415	c.2198G>C	c.(2197-2199)GGG>GCG	p.G733A		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	733	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTTTCCAGGGCATCTGGTG	0.652													56	79					0	0	0	0	C	140517214	C	C	140517214	3	2	278	1	0	0	0	0	1	0	0	0	11599	1232	43	4	2200	4	PCDHB5	5	140517214	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	102023339	140517214	40398046	33	52133											
JAKMIP2	9832	broad.mit.edu	37	chr5	147040903	147040903	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctccttcatcttctcctCatggagcttggctttgagtt	5	16	8	12	0	4	1	2	1	2	0	6	2	5	2	2	2	2	4	2	2	0	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr5:147040903C>T	uc003loq.1	-	3	617	c.235G>A	c.(235-237)GAG>AAG	p.E79K	JAKMIP2_uc011dbx.1_Missense_Mutation_p.E37K|JAKMIP2_uc003lor.1_Missense_Mutation_p.E79K|uc003lop.1_3'UTR|JAKMIP2_uc010jgo.1_Missense_Mutation_p.E79K	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	79	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTTCTCCTCATGGAGCTTG	0.517													64	65					0	0	0	0	T	147040903	T	T	147040903	3	4	278	1	0	0	0	0	1	0	0	0	7980	835	29	2	2273	2	JAKMIP2	5	147040903	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	6523689	147040903	33874357	34	52134											
C6orf10	10665	broad.mit.edu	37	chr6	32337718	32337718	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttaacaaaatagccaggAtggcaagtcccagtagagtc	14	9	10	8	0	0	1	0	0	0	1	2	2	1	2	2	2	2	3	2	2	6	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:32337718A>C	uc011dpy.1	-	2	229	c.56T>G	c.(55-57)ATC>AGC	p.I19S	C6orf10_uc011dpz.1_Missense_Mutation_p.I19S	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	19	Helical; (Potential).					integral to membrane				skin(1)	1						AATAGCCAGGATGGCAAGTCC	0.403													64	102					0	0	0	0	C	32337718	C	C	32337718	3	2	278	1	0	0	0	0	1	0	0	0	2327	333	12	5	1427	5	C6orf10	6	32337718	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08		32337718	138777349	35	52135											
PHF3	23469	broad.mit.edu	37	chr6	64422440	64422440	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcaacctgaaaagggatccTaggcaagcagcaggacgaag	16	4	12	9	1	1	1	1	1	0	0	2	4	2	3	2	3	3	3	2	3	6	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:64422440T>A	uc003pep.1	+	15	4982	c.4956T>A	c.(4954-4956)CCT>CCA	p.P1652P	PHF3_uc003pen.2_Silent_p.P1564P|PHF3_uc011dxs.1_Silent_p.P921P	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1652					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AAAGGGATCCTAGGCAAGCAG	0.453													10	27					0	0	0	0	A	64422440	A	A	64422440	2	1	278	1	0	0	0	0	0	0	0	1	11891	1509	53	5		5	PHF3	6	64422440	Silent	SNP	T	TCGA-D6-6823-01A-11D-1912-08	32084722	64422440	106692627	36	52136											
SIM1	6492	broad.mit.edu	37	chr6	100838366	100838366	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaatagtttctaatggtttcGctgtcatataagtgctccag	10	15	9	7	1	2	0	1	0	1	0	4	1	3	0	1	1	1	4	1	1	5	6			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:100838366G>T	uc003pqj.3	-	11	2379	c.2172C>A	c.(2170-2172)AGC>AGA	p.S724R	SIM1_uc010kcu.2_Missense_Mutation_p.S724R	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	724	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TAATGGTTTCGCTGTCATATA	0.463													17	83					0.000566183	0.00281084	1	0	T	100838366	T	T	100838366	3	4	278	1	0	0	0	0	1	0	0	0	14388	1078	38	3	132	3	SIM1	6	100838366	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	36415926	100838366	70276701	37	52137											
GPR126	57211	broad.mit.edu	37	chr6	142718817	142718817	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttggaaggaaaaatcattCagcagaagctcctaaaaaat	19	9	7	6	0	2	1	2	0	0	1	3	3	3	3	1	2	2	2	1	2	7	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:142718817C>G	uc010khc.2	+	10	1903	c.1492C>G	c.(1492-1494)CAG>GAG	p.Q498E	GPR126_uc010khd.2_Missense_Mutation_p.Q470E|GPR126_uc010khe.2_Missense_Mutation_p.Q498E|GPR126_uc010khf.2_Missense_Mutation_p.Q470E	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	498	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		AAAAATCATTCAGCAGAAGCT	0.373													5	36					0	0	0	0	G	142718817	G	G	142718817	3	3	278	1	0	0	0	0	1	0	0	0	6678	827	29	2	1530	2	GPR126	6	142718817	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	41880451	142718817	28396250	38	52138											
SYNE1	23345	broad.mit.edu	37	chr6	152757214	152757214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctcagcctggactgcaataCtttctgtccgtttagaaaac	10	13	7	11	1	2	1	1	0	2	1	4	2	3	2	2	1	4	2	2	1	5	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:152757214C>T	uc010kiw.2	-	33	4774	c.4172G>A	c.(4171-4173)AGT>AAT	p.S1391N	SYNE1_uc003qot.3_Missense_Mutation_p.S1398N|SYNE1_uc003qou.3_Missense_Mutation_p.S1391N|SYNE1_uc010kjb.1_Missense_Mutation_p.S1374N|SYNE1_uc003qow.2_Missense_Mutation_p.S686N|SYNE1_uc003qox.1_Missense_Mutation_p.S907N	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1391	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACTGCAATACTTTCTGTCCG	0.398										HNSCC(10;0.0054)			7	47					0	0	0	0	T	152757214	T	T	152757214	3	4	278	1	0	0	0	0	1	0	0	0	15511	565	20	4	22750	4	SYNE1	6	152757214	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	10038397	152757214	18357853	39	52139											
SYNJ2	8871	broad.mit.edu	37	chr6	158516842	158516842	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cagcatcagacgaagcccctCctggggcaggagcctctgtg	8	6	13	14	1	2	1	1	0	1	1	3	3	3	2	4	3	3	2	4	3	1	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr6:158516842C>T	uc003qqx.1	+	27	4012	c.3937C>T	c.(3937-3939)CCT>TCT	p.P1313S	SYNJ2_uc003qqy.1_Missense_Mutation_p.P1026S|SYNJ2_uc003qqz.1_Missense_Mutation_p.P930S|SYNJ2_uc003qra.1_Missense_Mutation_p.P656S|SYNJ2_uc010kjp.1_Missense_Mutation_p.P196S	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1313	Catalytic (By similarity).|Pro-rich.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CGAAGCCCCTCCTGGGGCAGG	0.632													6	56					0	0	0	0	T	158516842	T	T	158516842	3	4	278	1	0	0	0	0	1	0	0	0	15519	855	30	2	4043	2	SYNJ2	6	158516842	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	5759628	158516842	12598225	40	52140											
SEMA3E	9723	broad.mit.edu	37	chr7	83119474	83119474	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctccaagctgagggaatataCaaggtccctgcctcccacga	11	7	9	14	1	0	1	0	1	0	0	3	3	3	2	4	2	3	1	4	2	5	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr7:83119474C>G	uc003uhy.1	-	2	698	c.232G>C	c.(232-234)GTA>CTA	p.V78L		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	78	Sema.				axon guidance	extracellular space|membrane	receptor activity	p.V78V(1)		ovary(3)	3		Medulloblastoma(109;0.109)				AGGGAATATACAAGGTCCCTG	0.413													8	45					0	0	0	0	G	83119474	G	G	83119474	3	3	278	1	0	0	0	0	1	0	0	0	14093	478	17	4	2159	4	SEMA3E	7	83119474	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08		83119474	76019189	41	52141											
MUC17	140453	broad.mit.edu	37	chr7	100682562	100682562	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacaactgcaaaagataccaGcatgccaatctcaactccta	16	8	4	13	0	1	1	1	0	1	1	3	1	2	1	3	0	7	2	3	0	8	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr7:100682562G>T	uc003uxp.1	+	3	7918	c.7865G>T	c.(7864-7866)AGC>ATC	p.S2622I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2622	Extracellular (Potential).|59 X approximate tandem repeats.|42.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AAAGATACCAGCATGCCAATC	0.453													75	310					1.79293e-35	1.05467e-34	1	0	T	100682562	T	T	100682562	3	4	278	1	0	0	0	0	1	0	0	0	10027	971	34	4	7875	4	MUC17	7	100682562	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	17563088	100682562	58456101	42	52142											
C7orf60	154743	broad.mit.edu	37	chr7	112462082	112462082	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaatgccatcagatgcataTgtgaaaattttgagtacttg	14	14	8	5	0	1	3	1	2	0	1	1	3	1	3	1	0	3	2	1	0	6	6			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr7:112462082T>C	uc003vgo.1	-	5	1062	c.935A>G	c.(934-936)CAT>CGT	p.H312R	C7orf60_uc011kms.1_Missense_Mutation_p.H338R	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	312										ovary(2)|skin(1)	3						CAGATGCATATGTGAAAATTT	0.388													10	32					0	0	0	0	C	112462082	C	C	112462082	3	2	278	1	0	0	0	0	1	0	0	0	2418	1464	51	5	286	5	C7orf60	7	112462082	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08	11779520	112462082	46676581	43	52143											
RP1	6101	broad.mit.edu	37	chr8	55539875	55539875	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	taaagggaagtatgaatagcTtctgtcaagttgatgctcac	13	12	10	6	0	3	2	2	2	1	0	3	3	3	3	0	1	2	4	0	1	7	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr8:55539875T>C	uc003xsd.1	+	4	3581	c.3433T>C	c.(3433-3435)TTC>CTC	p.F1145L	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1145					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATGAATAGCTTCTGTCAAGT	0.408													4	84					0	0	0	0	C	55539875	C	C	55539875	3	2	278	1	0	0	0	0	1	0	0	0	13597	1609	56	5	3443	5	RP1	8	55539875	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08		55539875	90824147	44	52144											
KCNB2	9312	broad.mit.edu	37	chr8	73849904	73849904	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagacccttgctgggcactGaggtttcagcgccttgtcag	7	10	12	12	1	2	2	2	1	0	1	2	2	2	2	2	2	2	3	2	2	0	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr8:73849904G>C	uc003xzb.2	+	3	2902	c.2314G>C	c.(2314-2316)GAG>CAG	p.E772Q		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	772	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GCTGGGCACTGAGGTTTCAGC	0.552													23	113					0	0	0	0	C	73849904	C	C	73849904	3	2	278	1	0	0	0	0	1	0	0	0	8052	1291	45	2	2320	2	KCNB2	8	73849904	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	18310029	73849904	72514118	45	52145											
TRHR	7201	broad.mit.edu	37	chr8	110131311	110131311	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcagtggttgtaattctgtTtgcccttttatggatgccct	5	17	11	8	0	1	0	0	0	1	0	1	1	1	1	2	3	2	4	2	3	2	6			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr8:110131311T>G	uc003ymz.3	+	2	840	c.824T>G	c.(823-825)TTT>TGT	p.F275C		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	275	Helical; Name=6; (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GTAATTCTGTTTGCCCTTTTA	0.408													38	375					0	0	0	0	G	110131311	G	G	110131311	3	3	278	1	0	0	0	0	1	0	0	0	16547	1841	64	5	830	5	TRHR	8	110131311	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08	36281407	110131311	36232711	46	52146											
CSMD3	114788	broad.mit.edu	37	chr8	113842012	113842012	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaattcttcaaaatttatctGgataacctagcagtaaacag	17	12	5	7	0	3	0	1	0	2	0	3	1	3	1	1	1	3	2	1	1	8	7			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr8:113842012G>T	uc003ynu.2	-	12	1921	c.1762C>A	c.(1762-1764)CAG>AAG	p.Q588K	CSMD3_uc003ynt.2_Missense_Mutation_p.Q548K|CSMD3_uc011lhx.1_Missense_Mutation_p.Q484K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	588	Extracellular (Potential).|CUB 3.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAATTTATCTGGATAACCTAG	0.388										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	29					0.000602214	0.00296866	1	0	T	113842012	T	T	113842012	3	4	278	1	0	0	0	0	1	0	0	0	3963	1357	47	4	9601	4	CSMD3	8	113842012	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	3710701	113842012	32522010	47	52147											
ZNF572	137209	broad.mit.edu	37	chr8	125989980	125989980	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcagcatcggaaaattcaCgtagaaaagccttttgagtc	14	10	9	8	2	2	2	2	1	0	1	4	3	2	3	1	1	2	2	1	1	5	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr8:125989980C>T	uc003yrr.2	+	3	1625	c.1470C>T	c.(1468-1470)CAC>CAT	p.H490H		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	490	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GGAAAATTCACGTAGAAAAGC	0.473										HNSCC(60;0.17)			18	183					0	0	0	0	T	125989980	T	T	125989980	2	4	278	1	0	0	0	0	0	0	0	1	18071	535	19	1		1	ZNF572	8	125989980	Silent	SNP	C	TCGA-D6-6823-01A-11D-1912-08	12147968	125989980	20374042	48	52148											
CBWD6	644019	broad.mit.edu	37	chr9	69238242	69238242	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttttgtacctaagtgtcgttCttaatttctttacatcttct	7	22	4	8	1	4	0	0	0	4	0	5	0	4	0	1	0	2	2	1	0	4	10			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr9:69238242C>T	uc004afj.3	-	8	756	c.650G>A	c.(649-651)AGA>AAA	p.R217K	CBWD6_uc004afk.3_Intron|CBWD6_uc011lrf.1_Intron	NM_001085457	NP_001078926	Q4V339	CBWD6_HUMAN	COBW domain containing 6	217							ATP binding				0						AAGTGTCGTTCTTAATTTCTT	0.333													36	53					0	0	0	0	T	69238242	T	T	69238242	3	4	278	1	0	0	0	0	1	0	0	0	2728	913	32	2	569	2	CBWD6	9	69238242	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08		69238242	71975189	49	52149											
FRMD3	257019	broad.mit.edu	37	chr9	85863354	85863354	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcttcactagggggatcttCatactcccgggctgccttca	6	12	9	14	1	5	0	3	0	2	0	6	1	6	1	2	3	2	1	2	3	2	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr9:85863354C>G	uc004ams.1	-	14	1475	c.1273G>C	c.(1273-1275)GAA>CAA	p.E425Q	FRMD3_uc004amr.1_Missense_Mutation_p.E411Q|FRMD3_uc004amq.1_Missense_Mutation_p.E82Q	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	425						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						GGGGGATCTTCATACTCCCGG	0.468													12	37					0	0	0	0	G	85863354	G	G	85863354	3	3	278	1	0	0	0	0	1	0	0	0	6084	835	29	2	524	2	FRMD3	9	85863354	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	16625112	85863354	55350077	50	52150											
RASGEF1A	221002	broad.mit.edu	37	chr10	43692516	43692516	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgtccatgtcatgaacTcatggatctgtctggagatc	8	13	10	10	0	4	2	2	1	2	1	6	4	5	3	2	2	1	0	2	2	1	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr10:43692516T>C	uc001jap.1	-	11	1337	c.1256A>G	c.(1255-1257)GAG>GGG	p.E419G	RASGEF1A_uc001jao.1_Missense_Mutation_p.E427G	NM_145313	NP_660356	Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	419	Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						TGTCATGAACTCATGGATCTG	0.517													13	56					0	0	0	0	C	43692516	C	C	43692516	3	2	278	1	0	0	0	0	1	0	0	0	13134	1551	54	5	201	5	RASGEF1A	10	43692516	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08		43692516	91842231	51	52151											
OR52M1	119772	broad.mit.edu	37	chr11	4566851	4566851	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gctcacttatacagtggtggGtcgtttggggcttgtttctc	4	16	13	8	1	2	0	1	0	1	0	4	0	2	0	0	4	1	4	0	4	2	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:4566851G>A	uc010qyf.1	+	1	431	c.431G>A	c.(430-432)GGT>GAT	p.G144D		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACAGTGGTGGGTCGTTTGGGG	0.522													28	60					0	0	0	0	A	4566851	A	A	4566851	3	1	278	1	0	0	0	0	1	0	0	0	11180	1261	44	4	433	4	OR52M1	11	4566851	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08		4566851	130439665	52	52152											
OR51A4	401666	broad.mit.edu	37	chr11	4967421	4967421	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgacacaattttgctacaaCtctcactctaatctgtttag	11	16	4	10	0	3	1	1	1	3	0	4	1	3	1	0	0	3	2	0	0	5	7			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:4967421C>T	uc010qys.1	-	1	910	c.910G>A	c.(910-912)GTT>ATT	p.V304I		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTTGCTACAACTCTCACTCTA	0.353													28	254					0	0	0	0	T	4967421	T	T	4967421	3	4	278	1	0	0	0	0	1	0	0	0	11141	565	20	4	33	4	OR51A4	11	4967421	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	400570	4967421	130039095	53	52153											
NAV2	89797	broad.mit.edu	37	chr11	19735323	19735323	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccgcgcccatcctgcacgtgCccccggcccgggcgggcccc	2	3	13	23	6	0	0	0	0	0	0	1	0	1	0	8	3	2	1	8	3	0	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:19735323C>T	uc010rdm.1	+	1	443	c.82C>T	c.(82-84)CCC>TCC	p.P28S	NAV2_uc001mpp.2_Intron|NAV2_uc001mpr.3_Missense_Mutation_p.P28S|LOC100126784_uc010rdl.1_3'UTR	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	28						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						CCTGCACGTgcccccggcccg	0.547													7	25					0	0	0	0	T	19735323	T	T	19735323	3	4	278	1	0	0	0	0	1	0	0	0	10237	739	26	4	163	4	NAV2	11	19735323	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	14767902	19735323	115271193	54	52154											
EHF	26298	broad.mit.edu	37	chr11	34673089	34673089	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttctctattttttgtagAgccttccatcatgaacacct	8	17	4	12	0	2	2	1	1	1	1	5	2	4	2	4	0	2	1	4	0	3	7			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:34673089A>T	uc001mvr.1	+	5	518	c.407A>T	c.(406-408)GAG>GTG	p.E136V	EHF_uc009yke.1_Missense_Mutation_p.E136V|EHF_uc009ykf.1_Missense_Mutation_p.E139V	NM_012153	NP_036285	Q9NZC4	EHF_HUMAN	ets homologous factor	136					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			TTTTTTGTAGAGCCTTCCATC	0.423													20	41					0	0	0	0	T	34673089	T	T	34673089	3	4	278	1	0	0	0	0	1	0	0	0	5003	318	11	5	421	5	EHF	11	34673089	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	14937766	34673089	100333427	55	52155											
SPI1	6688	broad.mit.edu	37	chr11	47381575	47381575	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctgtgcacgtggtgggggtgGaagtcccagtaatggtctgt	6	11	17	7	1	1	0	0	0	1	0	2	1	2	1	1	5	1	2	1	5	2	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:47381575G>C	uc001nfc.1	-	3	382	c.159C>G	c.(157-159)TTC>TTG	p.F53L	SPI1_uc001nfb.1_Missense_Mutation_p.F54L|SLC39A13_uc001nfd.2_Intron|SPI1_uc009ylp.1_Missense_Mutation_p.F47L	NM_003120	NP_003111	P17947	SPI1_HUMAN	hematopoietic transcription factor PU.1 isoform	53					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of erythrocyte differentiation	nucleus	protein binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)	2				Lung(87;0.0967)		GGTGGGGGTGGAAGTCCCAGT	0.582													6	6					0	0	0	0	C	47381575	C	C	47381575	3	2	278	1	0	0	0	0	1	0	0	0	15115	1165	41	2	665	2	SPI1	11	47381575	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	12708486	47381575	87624941	56	52156											
OR8J1	219477	broad.mit.edu	37	chr11	56128447	56128447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaagccttttctacctgtgCttcacatatgatggcagtca	11	13	7	10	0	3	1	2	1	1	0	3	1	3	1	2	1	3	2	2	1	4	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:56128447C>T	uc010rjh.1	+	1	725	c.725C>T	c.(724-726)GCT>GTT	p.A242V		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TCTACCTGTGCTTCACATATG	0.348													35	69					0	0	0	0	T	56128447	T	T	56128447	3	4	278	1	0	0	0	0	1	0	0	0	11295	797	28	4	727	4	OR8J1	11	56128447	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	8746872	56128447	78878069	57	52157											
SF3B2	10992	broad.mit.edu	37	chr11	65826722	65826722	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggagccagagaaacttgaCaaactggagaactctgcagc	16	5	11	9	0	1	3	0	1	1	2	1	6	1	4	1	2	6	1	1	2	4	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:65826722C>T	uc001ogy.1	+	11	1273	c.1233C>T	c.(1231-1233)GAC>GAT	p.D411D		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	411					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						AGAAACTTGACAAACTGGAGA	0.532													10	27					0	0	0	0	T	65826722	T	T	65826722	2	4	278	1	0	0	0	0	0	0	0	1	14216	477	17	4		4	SF3B2	11	65826722	Silent	SNP	C	TCGA-D6-6823-01A-11D-1912-08	9698275	65826722	69179794	58	52158											
INPPL1	3636	broad.mit.edu	37	chr11	71939892	71939892	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acagctccagctgctgagagGtgagacccccatcccatcca	10	6	9	16	0	0	2	0	2	0	2	3	4	3	2	5	1	3	3	5	1	0	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:71939892G>A	uc001osf.2	+	4	665	c.518_splice	c.e4+1	p.S173_splice	INPPL1_uc001osg.2_Splice_Site	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1						actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						CTGCTGAGAGGTGAGACCCCC	0.627													21	44					0	0	0	0	A	71939892	A	A	71939892	5	1	278	1	0	0	0	0	0	0	1	0	7800	1275	44	4	533	4	INPPL1	11	71939892	Splice_Site	SNP	G	TCGA-D6-6823-01A-11D-1912-08	6113170	71939892	63066624	59	52159											
USP35	57558	broad.mit.edu	37	chr11	77924730	77924730	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagcagggcggcctacatCtctgcactccccacatctcc	7	7	9	18	2	2	0	0	0	2	0	5	1	3	1	4	3	3	2	4	3	1	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:77924730C>A	uc009yva.1	+	11	3174	c.2928C>A	c.(2926-2928)ATC>ATA	p.I976I	USP35_uc001ozc.2_Silent_p.I544I|USP35_uc010rsp.1_Silent_p.I408I|USP35_uc001ozd.2_Silent_p.I587I|USP35_uc001ozf.2_Silent_p.I707I	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	976					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CGGCCTACATCTCTGCACTCC	0.577													19	53					4.96729e-08	2.61436e-07	1	0	A	77924730	A	A	77924730	2	1	278	1	0	0	0	0	0	0	0	1	17134	903	32	2		2	USP35	11	77924730	Silent	SNP	C	TCGA-D6-6823-01A-11D-1912-08	5984838	77924730	57081786	60	52160											
FAT3	120114	broad.mit.edu	37	chr11	92085482	92085482	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcaacagccagagtagaatGggcatcaccttaatagatct	14	9	9	9	0	3	3	2	0	1	3	3	3	3	3	2	1	2	2	2	1	5	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:92085482G>A	uc001pdj.3	+	1	221	c.204G>A	c.(202-204)ATG>ATA	p.M68I		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	68	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGAGTAGAATGGGCATCACCT	0.458										TCGA Ovarian(4;0.039)			16	48					0	0	0	0	A	92085482	A	A	92085482	3	1	278	1	0	0	0	0	1	0	0	0	5723	1348	47	4	206	4	FAT3	11	92085482	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	14160752	92085482	42921034	61	52161											
SLC36A4	120103	broad.mit.edu	37	chr11	92901243	92901243	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atggaagaaagcaaagcataTatatccttaggtcaacactt	17	10	7	7	0	1	1	1	0	0	1	2	2	2	2	1	2	3	2	1	2	8	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:92901243T>C	uc001pdn.2	-	7	732	c.635A>G	c.(634-636)TAT>TGT	p.Y212C	SLC36A4_uc001pdm.2_Missense_Mutation_p.Y77C	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid	212	Helical; (Potential).				L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GCAAAGCATATATATCCTTAG	0.353													19	47					0	0	0	0	C	92901243	C	C	92901243	3	2	278	1	0	0	0	0	1	0	0	0	14660	1406	49	5	899	5	SLC36A4	11	92901243	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08	815761	92901243	42105273	62	52162											
JRKL	8690	broad.mit.edu	37	chr11	96125222	96125222	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaggaggaggaaatagaacTaattccagagaaacatatta	19	8	10	4	0	0	3	0	1	0	2	1	7	1	6	1	3	2	0	1	3	7	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:96125222T>G	uc009ywu.2	+	2	1661	c.1409T>G	c.(1408-1410)CTA>CGA	p.L470R	CCDC82_uc001pfx.3_5'Flank|CCDC82_uc009ywr.2_5'Flank|CCDC82_uc009ywt.1_5'Flank|JRKL_uc001pfy.2_Missense_Mutation_p.L470R	NM_003772	NP_003763	Q9Y4A0	JERKL_HUMAN	jerky homolog-like	470					central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		GAAATAGAACTAATTCCAGAG	0.398													5	22					0	0	0	0	G	96125222	G	G	96125222	3	3	278	1	0	0	0	0	1	0	0	0	8004	1522	53	5	1411	5	JRKL	11	96125222	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08	3223979	96125222	38881294	63	52163											
ROBO4	54538	broad.mit.edu	37	chr11	124756427	124756427	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctatccacagccactgccagGgcccgggcaaagtgagcatc	10	5	11	15	1	0	1	0	1	0	0	2	1	1	1	4	2	3	2	4	2	2	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr11:124756427G>T	uc001qbg.2	-	16	2867	c.2727C>A	c.(2725-2727)GCC>GCA	p.A909A	ROBO4_uc010sas.1_Silent_p.A764A|ROBO4_uc001qbh.2_3'UTR|ROBO4_uc001qbi.2_Silent_p.A467A	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	909					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CCACTGCCAGGGCCCGGGCAA	0.602													8	39					5.18039e-06	2.62773e-05	1	0	T	124756427	T	T	124756427	2	4	278	1	0	0	0	0	0	0	0	1	13581	1219	43	4		4	ROBO4	11	124756427	Silent	SNP	G	TCGA-D6-6823-01A-11D-1912-08	28631205	124756427	10250089	64	52164											
FKBP4	2288	broad.mit.edu	37	chr12	2907902	2907902	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgagtttaagggagaagatCtgacggaagaggaagatggc	14	8	16	3	1	1	6	0	2	1	4	1	9	1	8	0	4	0	1	0	4	4	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:2907902C>A	uc001qkz.2	+	4	622	c.424C>A	c.(424-426)CTG>ATG	p.L142M		NM_002014	NP_002005	Q02790	FKBP4_HUMAN	FK506 binding protein 52	142					negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging				0			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	GGGAGAAGATCTGACGGAAGA	0.463													49	148					5.57489e-27	3.25202e-26	1	0	A	2907902	A	A	2907902	3	1	278	1	0	0	0	0	1	0	0	0	5942	912	32	2	438	2	FKBP4	12	2907902	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08		2907902	130943993	65	52165											
GALNT8	26290	broad.mit.edu	37	chr12	4854675	4854675	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgacaacattcgttttgacaCcttcaaactggataagtatg	13	13	7	8	1	1	2	1	2	0	0	2	3	1	3	1	1	2	2	1	1	4	6			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:4854675C>T	uc001qne.1	+	5	1033	c.941C>T	c.(940-942)ACC>ATC	p.T314I		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	314	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						CGTTTTGACACCTTCAAACTG	0.488													23	69					0	0	0	0	T	4854675	T	T	4854675	3	4	278	1	0	0	0	0	1	0	0	0	6254	507	18	4	959	4	GALNT8	12	4854675	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	1946773	4854675	128997220	66	52166											
KCNA1	3736	broad.mit.edu	37	chr12	5021157	5021157	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacgggcaccgtccaccgcAtcgacaacaccacggtcatc	10	5	8	18	5	2	0	2	0	0	0	5	1	3	0	4	2	1	2	4	2	1	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:5021157A>T	uc001qnh.2	+	2	1718	c.613A>T	c.(613-615)ATC>TTC	p.I205F		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	205					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CGTCCACCGCATCGACAACAC	0.537													19	48					0	0	0	0	T	5021157	T	T	5021157	3	4	278	1	0	0	0	0	1	0	0	0	8040	217	8	5	615	5	KCNA1	12	5021157	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	166482	5021157	128830738	67	52167											
PRB1	5542	broad.mit.edu	37	chr12	11506558	11506558	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tacctccttgtgggggtggtCcttgtggctttcctggagga	3	14	15	9	0	0	0	0	0	0	0	3	2	3	2	4	6	1	1	4	6	1	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:11506558C>A	uc001qzw.1	-	4	516	c.479G>T	c.(478-480)GGA>GTA	p.G160V	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	221	9.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGGGGTGGTCCTTGTGGCTT	0.602													15	45					7.38237e-10	3.97512e-09	1	0	A	11506558	A	A	11506558	3	1	278	1	0	0	0	0	1	0	0	0	12504	855	30	2	520	2	PRB1	12	11506558	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	6485401	11506558	122345337	68	52168											
PRB2	653247	broad.mit.edu	37	chr12	11546653	11546653	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcctccttgtgggggtggtCcttgtggctttcctggagga	2	14	16	9	0	0	0	0	0	0	0	3	2	3	2	4	6	1	1	4	6	0	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:11546653C>A	uc010shk.1	-	3	394	c.359G>T	c.(358-360)GGA>GTA	p.G120V		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGGGGTGGTCCTTGTGGCTT	0.597													32	713					6.90743e-12	3.7775e-11	1	0	A	11546653	A	A	11546653	3	1	278	1	0	0	0	0	1	0	0	0	12505	855	30	2	895	2	PRB2	12	11546653	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	40095	11546653	122305242	69	52169											
MRPS35	60488	broad.mit.edu	37	chr12	27888432	27888432	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgcaaagaagaaattaattaAacttgtaggagagcgatact	18	9	9	5	2	0	3	0	0	0	3	0	5	0	3	0	1	3	2	0	1	8	5			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:27888432A>C	uc001rih.2	+	6	623	c.575A>C	c.(574-576)AAA>ACA	p.K192T	MRPS35_uc001rii.2_Intron	NM_021821	NP_068593	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35 precursor	192					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit					0	Lung SC(9;0.0873)					AAATTAATTAAACTTGTAGGA	0.323													22	54					0	0	0	0	C	27888432	C	C	27888432	3	2	278	1	0	0	0	0	1	0	0	0	9897	14	1	5	597	5	MRPS35	12	27888432	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	16341779	27888432	105963463	70	52170											
KRT4	3851	broad.mit.edu	37	chr12	53201426	53201426	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaccctgcctaacccctcAcctgtactcctcgccctcca	7	8	3	23	1	1	0	1	0	0	0	4	0	3	0	8	0	3	1	8	0	2	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:53201426A>G	uc001saz.2	-	7	1839	c.1568_splice	c.e7+1	p.R523_splice		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4							keratin filament	structural molecule activity			ovary(4)|skin(2)	6						CTAACCCCTCACCTGTACTCC	0.582													31	57					0	0	0	0	G	53201426	G	G	53201426	5	3	278	1	0	0	0	0	0	0	1	0	8516	173	6	5	226	5	KRT4	12	53201426	Splice_Site	SNP	A	TCGA-D6-6823-01A-11D-1912-08	25312994	53201426	80650469	71	52171											
GALNT4	8693	broad.mit.edu	37	chr12	89917883	89917883	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	atggtacggagcaaagtcgaCcaggcttcgttatagaaagc	13	8	12	8	3	0	1	0	0	0	1	2	3	0	2	1	3	3	4	1	3	5	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:89917883C>A	uc001tbd.2	-	1	653	c.444G>T	c.(442-444)TGG>TGT	p.W148C	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Missense_Mutation_p.W145C|GALNT4_uc010suo.1_Intron	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	148	Lumenal (Potential).|Catalytic subdomain A.				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						GCAAAGTCGACCAGGCTTCGT	0.398											OREG0022018	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	45					1.33834e-09	7.09724e-09	1	0	A	89917883	A	A	89917883	3	1	278	1	0	0	0	0	1	0	0	0	6250	508	18	4	1296	4	GALNT4	12	89917883	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	36716457	89917883	43934012	72	52172											
ACTR6	64431	broad.mit.edu	37	chr12	100604114	100604114	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttaaccaatcatctaaaggAgatcatatcttacaggtgat	15	12	6	8	0	4	2	2	1	2	1	4	3	4	2	1	2	2	0	1	2	6	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:100604114A>T	uc001thb.1	+	6	613	c.557A>T	c.(556-558)GAG>GTG	p.E186V	ACTR6_uc001thc.1_Missense_Mutation_p.E78V|ACTR6_uc001thd.1_Missense_Mutation_p.E186V|ACTR6_uc009ztu.1_5'UTR|ACTR6_uc001the.1_Missense_Mutation_p.E104V|ACTR6_uc001thf.1_Missense_Mutation_p.E104V|uc001thg.1_Intron	NM_022496	NP_071941	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog	186						cytoplasm|cytoskeleton				ovary(1)	1						CATCTAAAGGAGATCATATCT	0.358													33	75					0	0	0	0	T	100604114	T	T	100604114	3	4	278	1	0	0	0	0	1	0	0	0	216	304	11	5	579	5	ACTR6	12	100604114	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	10686231	100604114	33247781	73	52173											
NCOR2	9612	broad.mit.edu	37	chr12	124979778	124979778	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctccacgtctgtgccacaGgctgtgtggatcccgacatg	6	9	11	15	2	1	0	0	0	1	0	3	2	3	1	4	2	1	1	4	2	0	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr12:124979778G>A	uc010tba.1	-	1	137	c.20C>T	c.(19-21)CCT>CTT	p.P7L	NCOR2_uc010tay.1_Missense_Mutation_p.P7L|NCOR2_uc010taz.1_Missense_Mutation_p.P7L|NCOR2_uc010tbb.1_Missense_Mutation_p.P7L|NCOR2_uc010tbc.1_Missense_Mutation_p.P7L|NCOR2_uc001ugj.1_Missense_Mutation_p.P7L|NCOR2_uc001ugk.1_Missense_Mutation_p.P7L	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	7				P -> L (in Ref. 2; AAD20946).	cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CTGTGCCACAGGCTGTGTGGA	0.627													5	29					0	0	0	0	A	124979778	A	A	124979778	3	1	278	1	0	0	0	0	1	0	0	0	10290	1000	35	4	7736	4	NCOR2	12	124979778	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	24375664	124979778	8872117	74	52174											
KIAA1704	55425	broad.mit.edu	37	chr13	45580367	45580367	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaatcaggatgatgacgaTgatgatgatgatgggttttt	14	13	12	2	1	1	6	1	6	0	0	1	8	1	7	0	2	0	1	0	2	2	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr13:45580367T>C	uc001uzq.2	+	3	355	c.252T>C	c.(250-252)GAT>GAC	p.D84D	KIAA1704_uc010tfo.1_RNA|KIAA1704_uc001uzr.1_Silent_p.D84D|KIAA1704_uc001uzs.2_5'UTR|KIAA1704_uc001uzt.2_5'UTR	NM_018559	NP_061029	Q8IXQ4	K1704_HUMAN	hypothetical protein LOC55425	84	Poly-Asp.									pancreas(1)|skin(1)	2		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		atgatgacgatgatgatgatg	0.289													4	175					0	0	0	0	C	45580367	C	C	45580367	2	2	278	1	0	0	0	0	0	0	0	1	8291	1461	51	5		5	KIAA1704	13	45580367	Silent	SNP	T	TCGA-D6-6823-01A-11D-1912-08		45580367	69589511	75	52175											
LCP1	3936	broad.mit.edu	37	chr13	46716466	46716466	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaaggccagtgtgagagtgCggtttccttcattgagatct	8	13	12	8	1	3	2	2	2	1	2	4	4	4	2	2	2	1	1	2	2	1	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr13:46716466C>T	uc001vaz.3	-	13	1589	c.1463G>A	c.(1462-1464)CGC>CAC	p.R488H	LCP1_uc010ack.2_Missense_Mutation_p.R57H|LCP1_uc001vay.3_Missense_Mutation_p.R85H|LCP1_uc001vba.3_Missense_Mutation_p.R488H	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	488	Actin-binding 2.|CH 3.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TGTGAGAGTGCGGTTTCCTTC	0.413			T	BCL6	NHL 								16	97					0	0	0	0	T	46716466	T	T	46716466	3	4	278	1	0	0	0	0	1	0	0	0	8731	768	27	1	436	1	LCP1	13	46716466	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	1136099	46716466	68453412	76	52176											
OR11H12	440153	broad.mit.edu	37	chr14	19378056	19378056	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaatatcatgactgggcatCtctgtgccaaactggtcata	11	12	8	10	0	3	1	2	1	1	0	4	1	3	1	1	2	2	1	1	2	4	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:19378056C>A	uc010tkp.1	+	1	463	c.463C>A	c.(463-465)CTC>ATC	p.L155I		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	155	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GACTGGGCATCTCTGTGCCAA	0.473													34	436					3.62531e-18	2.06318e-17	1	0	A	19378056	A	A	19378056	3	1	278	1	0	0	0	0	1	0	0	0	10981	913	32	2	465	2	OR11H12	14	19378056	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08		19378056	87971484	77	52177											
OXA1L	5018	broad.mit.edu	37	chr14	23240279	23240279	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttttccctggtccaagtatCctgtctccggattccagcag	6	13	9	13	1	1	0	0	0	1	0	6	1	5	1	5	2	1	3	5	2	2	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:23240279C>A	uc001wgn.2	+	8	1172	c.1172C>A	c.(1171-1173)TCC>TAC	p.S391Y	OXA1L_uc001wgo.2_RNA|OXA1L_uc010akc.2_Missense_Mutation_p.S391Y|OXA1L_uc001wgp.2_Missense_Mutation_p.S315Y|OXA1L_uc001wgq.2_Missense_Mutation_p.S95Y	NM_005015	NP_005006	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	331	Mitochondrial matrix (Potential).				aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)	1	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		GTCCAAGTATCCTGTCTCCGG	0.507													51	105					2.69953e-25	1.56171e-24	1	0	A	23240279	A	A	23240279	3	1	278	1	0	0	0	0	1	0	0	0	11382	855	30	2	1202	2	OXA1L	14	23240279	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	3862223	23240279	84109261	78	52178											
MUDENG	55745	broad.mit.edu	37	chr14	57741158	57741159	+	Frame_Shift_Ins	INS	-	A	A																															tggactcctgataggaggtgINSaagaactctggccagttgtt																										TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:57741158_57741159insA	uc001xcv.2	+	2	698_699	c.271_272insA	c.(271-273)GAAfs	p.E91fs	MUDENG_uc001xcu.3_Frame_Shift_Ins_p.E91fs|MUDENG_uc010tri.1_Intron|MUDENG_uc010trj.1_5'UTR	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	91					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1						GATAGGAGGTGAAGAACTCTGG	0.406													---	---	---								A	57741159	A	A	57741158	7	5	278	1	0	1	1	0	0	0	0	0	10036	1291	45	0	277	0	MUDENG	14	57741158	Frame_Shift_Ins	INS	-	TCGA-D6-6823-01A-11D-1912-08	34500879	57741158	49608382	79	52179											
KIAA1737	85457	broad.mit.edu	37	chr14	77579969	77579969	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagccccacatccaggcaaaAggggcctttcccttggccca	9	7	9	16	0	0	0	0	0	0	0	2	0	2	0	6	4	1	1	6	4	3	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:77579969A>G	uc001xtd.2	+	4	687	c.508A>G	c.(508-510)AGG>GGG	p.R170G	KIAA1737_uc001xtc.1_Missense_Mutation_p.R72G	NM_033426	NP_219494	Q9C0C6	K1737_HUMAN	KIAA1737 protein	170											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0284)		TCCAGGCAAAAGGGGCCTTTC	0.488													3	105					0	0	0	0	G	77579969	G	G	77579969	3	3	278	1	0	0	0	0	1	0	0	0	8294	63	3	5	518	5	KIAA1737	14	77579969	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	19838811	77579969	29769571	80	52180											
JAG2	3714	broad.mit.edu	37	chr14	105613864	105613864	+	Frame_Shift_Del	DEL	T	-	-																															gagggttgcagtcgttggtaTctggtttgggagaagagaac																										TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr14:105613864delT	uc001yqg.2	-	19	2770	c.2366delA	c.(2365-2367)AATfs	p.N789fs	JAG2_uc010axf.2_5'Flank|JAG2_uc001yqf.2_Frame_Shift_Del_p.N193fs|JAG2_uc001yqh.2_Frame_Shift_Del_p.N751fs	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	789	Extracellular (Potential).|EGF-like 15; calcium-binding (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		GTCGTTGGTATCTGGTTTGGG	0.652													---	---	---								-	105613864	-	-	105613864	7	5	278	1	0	1	0	1	0	0	0	0	7974	1449	50	0	1382	0	JAG2	14	105613864	Frame_Shift_Del	DEL	T	TCGA-D6-6823-01A-11D-1912-08	28033895	105613864	1735676	81	52181											
FAM98B	283742	broad.mit.edu	37	chr15	38773633	38773633	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acaagtagtggcaccagccgGgagaagaccgcatgtgccat	12	5	13	11	2	0	2	0	0	0	2	0	3	0	2	4	2	2	3	4	2	3	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr15:38773633G>A	uc001zkb.1	+	7	905	c.870G>A	c.(868-870)CGG>CGA	p.R290R	FAM98B_uc001zkc.2_Silent_p.R290R	NM_001042429	NP_001035894	Q52LJ0	FA98B_HUMAN	family with sequence similarity 98, member B	290						tRNA-splicing ligase complex	protein binding			ovary(1)	1		all_cancers(109;3.11e-17)|all_epithelial(112;2.64e-15)|Lung NSC(122;2.11e-11)|all_lung(180;5.61e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;9e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0209)		GCACCAGCCGGGAGAAGACCG	0.398													11	48					0	0	0	0	A	38773633	A	A	38773633	2	1	278	1	0	0	0	0	0	0	0	1	5689	1219	43	4		4	FAM98B	15	38773633	Silent	SNP	G	TCGA-D6-6823-01A-11D-1912-08		38773633	63757759	82	52182											
FBN1	2200	broad.mit.edu	37	chr15	48784730	48784730	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttgaatgaccccctagtgtTaacacacaggccatttttac	11	12	6	12	0	0	2	0	2	0	0	0	2	0	2	3	1	2	1	3	1	4	6			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr15:48784730T>G	uc001zwx.1	-	24	3110	c.2782A>C	c.(2782-2784)AAC>CAC	p.N928H		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	928	EGF-like 14; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCCCTAGTGTTAACACACAGG	0.348													8	36					0	0	0	0	G	48784730	G	G	48784730	3	3	278	1	0	0	0	0	1	0	0	0	5734	1754	61	5	6005	5	FBN1	15	48784730	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08	10011097	48784730	53746662	83	52183											
SNX33	257364	broad.mit.edu	37	chr15	75941779	75941779	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggtagctttgaggaggaTgatgatgatgactgggatga	11	10	17	3	0	0	6	0	6	0	0	0	9	0	9	0	4	1	2	0	4	1	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr15:75941779T>G	uc002bau.2	+	1	432	c.336T>G	c.(334-336)GAT>GAG	p.D112E	IMP3_uc002bat.2_5'Flank|SNX33_uc002bav.2_5'Flank	NM_153271	NP_695003	Q8WV41	SNX33_HUMAN	sorting nexin 33	112	Poly-Asp.				cell communication		phosphatidylinositol binding|protein binding			ovary(1)	1						TTGAGGAGGATGATGATGATG	0.622													3	100					0	0	0	0	G	75941779	G	G	75941779	3	3	278	1	0	0	0	0	1	0	0	0	14967	1461	51	5	338	5	SNX33	15	75941779	Missense_Mutation	SNP	T	TCGA-D6-6823-01A-11D-1912-08	27157049	75941779	26589613	84	52184											
NTRK3	4916	broad.mit.edu	37	chr15	88678559	88678559	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgttggtggggggttgccaCgcaccacaaactcgatgcag	8	7	15	11	3	0	0	0	0	0	0	1	1	0	0	2	4	3	4	2	4	1	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr15:88678559C>A	uc002bme.1	-	9	1139	c.977G>T	c.(976-978)CGT>CTT	p.R326L	NTRK3_uc002bmh.2_Missense_Mutation_p.R326L|NTRK3_uc002bmf.1_Missense_Mutation_p.R326L|NTRK3_uc010upl.1_Missense_Mutation_p.R228L|NTRK3_uc010bnh.1_Missense_Mutation_p.R326L|NTRK3_uc002bmg.2_Missense_Mutation_p.R326L	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	326	Ig-like C2-type 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGGGTTGCCACGCACCACAAA	0.592			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			22	38					5.26018e-13	2.92232e-12	1	0	A	88678559	A	A	88678559	3	1	278	1	0	0	0	0	1	0	0	0	10762	536	19	3	1848	3	NTRK3	15	88678559	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	12736780	88678559	13852833	85	52185											
CDH8	1006	broad.mit.edu	37	chr16	61687669	61687669	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgaccctcggccttcatagCcatatatctgaatggagtca	10	11	8	12	1	3	2	2	2	1	0	4	3	3	3	3	2	1	0	3	2	4	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr16:61687669C>A	uc002eog.1	-	12	2495	c.2243G>T	c.(2242-2244)GGC>GTC	p.G748V		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	748	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GCCTTCATAGCCATATATCTG	0.502													14	45					6.72482e-11	3.64913e-10	1	0	A	61687669	A	A	61687669	3	1	278	1	0	0	0	0	1	0	0	0	3131	739	26	4	160	4	CDH8	16	61687669	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08		61687669	28667084	86	52186											
CDH16	1014	broad.mit.edu	37	chr16	66947070	66947070	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggatgctgactgtggggtCacggggagggcagataggca	9	6	20	6	1	1	2	1	1	0	1	1	4	1	4	0	7	1	3	0	7	1	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr16:66947070C>T	uc002eql.2	-	9	1091	c.1018G>A	c.(1018-1020)GAC>AAC	p.D340N	CDH16_uc010cdy.2_Missense_Mutation_p.D340N|CDH16_uc002eqm.2_Missense_Mutation_p.D243N	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	340	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		ACTGTGGGGTCACGGGGAGGG	0.587													33	118					0	0	0	0	T	66947070	T	T	66947070	3	4	278	1	0	0	0	0	1	0	0	0	3116	826	29	2	1511	2	CDH16	16	66947070	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	5259401	66947070	23407683	87	52187											
CDH3	1001	broad.mit.edu	37	chr16	68732227	68732227	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcctccgaccaagaccaagAttacgattatctgaacgagt	13	8	8	12	4	1	3	0	1	1	2	2	6	2	3	4	0	2	0	4	0	5	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr16:68732227A>G	uc002ewf.2	+	16	3546	c.2414A>G	c.(2413-2415)GAT>GGT	p.D805G	CDH3_uc010vli.1_Missense_Mutation_p.D750G	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	805	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CAAGACCAAGATTACGATTAT	0.642													34	112					0	0	0	0	G	68732227	G	G	68732227	3	3	278	1	0	0	0	0	1	0	0	0	3126	333	12	5	2476	5	CDH3	16	68732227	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	1785157	68732227	21622526	88	52188											
PKD1L2	114780	broad.mit.edu	37	chr16	81145910	81145910	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcttcactgtggacaggAgtaccaggaaggcaatgatg	14	7	13	7	0	1	1	1	1	0	0	1	4	1	4	1	4	2	3	1	4	4	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr16:81145910A>T	uc002fgh.1	-	42	6842	c.6842T>A	c.(6841-6843)CTC>CAC	p.L2281H	PKD1L2_uc002fgf.1_Missense_Mutation_p.L81H|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2281	Helical; (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGTGGACAGGAGTACCAGGAA	0.547													11	82					0	0	0	0	T	81145910	T	T	81145910	3	4	278	1	0	0	0	0	1	0	0	0	12020	304	11	5	553	5	PKD1L2	16	81145910	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	12413683	81145910	9208843	89	52189											
FXR2	9513	broad.mit.edu	37	chr17	7497597	7497597	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcattatcaccttccactcGaaccctcaccacaccagatt	11	10	3	17	1	3	1	3	0	0	1	5	2	4	1	5	0	1	0	5	0	2	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:7497597G>A	uc002gia.1	-	10	1206	c.979C>T	c.(979-981)CGA>TGA	p.R327*	FXR2_uc010vud.1_Nonsense_Mutation_p.R327*	NM_004860	NP_004851	P51116	FXR2_HUMAN	fragile X mental retardation syndrome related	327						cytosolic large ribosomal subunit	protein binding|RNA binding				0				READ - Rectum adenocarcinoma(115;0.17)		CCTTCCACTCGAACCCTCACC	0.468													6	24					0	0	0	0	A	7497597	A	A	7497597	4	1	278	1	0	0	0	0	0	1	0	0	6150	1066	37	1	974	1	FXR2	17	7497597	Nonsense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08		7497597	73697613	90	52190											
TP53	7157	broad.mit.edu	37	chr17	7578520	7578520	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacagggcaggtcttggccAgttggcaaaacatcttgttg	9	10	13	9	0	2	0	0	0	2	0	2	0	2	0	1	4	1	5	1	4	2	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:7578520A>T	uc002gim.2	-	5	604	c.410T>A	c.(409-411)CTG>CAG	p.L137Q	TP53_uc002gig.1_Missense_Mutation_p.L137Q|TP53_uc002gih.2_Missense_Mutation_p.L137Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.L5Q|TP53_uc010cng.1_Missense_Mutation_p.L5Q|TP53_uc002gii.1_Missense_Mutation_p.L5Q|TP53_uc010cnh.1_Missense_Mutation_p.L137Q|TP53_uc010cni.1_Missense_Mutation_p.L137Q|TP53_uc002gij.2_Missense_Mutation_p.L137Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.L44Q|TP53_uc002gio.2_Missense_Mutation_p.L5Q|TP53_uc010vug.1_Missense_Mutation_p.L98Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	137	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> M (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> Q (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L137L(6)|p.L137P(3)|p.N131fs*27(2)|p.L137Q(2)|p.L137M(2)|p.V73fs*9(1)|p.L137_W146del10(1)|p.C135_T140delCQLAKT(1)|p.L137_A138insX(1)|p.L137fs*12(1)|p.C135_A138delCQLA(1)|p.K132_A138delKMFCQLA(1)|p.F134_T140>S(1)|p.Q136_K139delQLAK(1)|p.L137fs*33(1)|p.L137V(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTCTTGGCCAGTTGGCAAAA	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	21					0	0	0	0	T	7578520	T	T	7578520	3	4	278	1	0	0	0	0	1	0	0	0	16448	188	7	5	888	5	TP53	17	7578520	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	80923	7578520	73616690	91	52191											
DHX58	79132	broad.mit.edu	37	chr17	40256842	40256842	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccactgcctgctccatcAgcgtctccagcgcctcgttg	5	9	9	18	3	2	0	1	0	1	0	5	0	3	0	5	0	5	2	5	0	0	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:40256842A>C	uc002hyw.3	-	11	1728	c.1505T>G	c.(1504-1506)CTG>CGG	p.L502R	DHX58_uc002hyv.3_RNA|DHX58_uc010wgf.1_Missense_Mutation_p.L495R	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	502	Potential.|Helicase C-terminal.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTGCTCCATCAGCGTCTCCAG	0.632													7	17					0	0	0	0	C	40256842	C	C	40256842	3	2	278	1	0	0	0	0	1	0	0	0	4536	188	7	5	547	5	DHX58	17	40256842	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	32678322	40256842	40938368	92	52192											
BRCA1	672	broad.mit.edu	37	chr17	41256883	41256883	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttgggatattcaacacttAcactccaaacctgtgtcaag	12	12	6	11	0	3	0	2	0	1	0	4	1	4	1	2	1	3	0	2	1	5	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:41256883A>C	uc002icq.2	-	5	533	c.301_splice	c.e5+1	p.Y101_splice	BRCA1_uc010whp.1_Splice_Site_p.Y54_splice|BRCA1_uc010whl.1_Splice_Site_p.Y101_splice|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Splice_Site_p.Y31_splice|BRCA1_uc002icu.2_Splice_Site_p.Y101_splice|BRCA1_uc010cyx.2_Splice_Site_p.Y54_splice|BRCA1_uc002ict.2_Splice_Site_p.Y101_splice|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Splice_Site_p.Y101_splice|BRCA1_uc010whr.1_Splice_Site_p.Y54_splice|BRCA1_uc002idd.2_Splice_Site_p.Y101_splice|BRCA1_uc002ide.1_Intron|BRCA1_uc010cyy.1_Splice_Site_p.Y101_splice|BRCA1_uc010whs.1_Splice_Site_p.Y101_splice|BRCA1_uc010cyz.2_Splice_Site_p.Y54_splice|BRCA1_uc010cza.2_Splice_Site_p.Y75_splice|BRCA1_uc010wht.1_Intron	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1						androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TTCAACACTTACACTCCAAAC	0.373			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			28	47					0	0	0	0	C	41256883	C	C	41256883	5	2	278	1	0	0	0	0	0	0	1	0	1503	405	14	5	5434	5	BRCA1	17	41256883	Splice_Site	SNP	A	TCGA-D6-6823-01A-11D-1912-08	1000041	41256883	39938327	93	52193											
UBTF	7343	broad.mit.edu	37	chr17	42284865	42284865	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctcgctgctggactcagagGagtcgccgccatcttcagag	7	8	12	14	3	3	2	2	0	1	2	5	4	3	4	3	2	1	2	3	2	0	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:42284865G>A	uc002igb.2	-	19	2193	c.2126C>T	c.(2125-2127)TCC>TTC	p.S709F	UBTF_uc002igc.2_Missense_Mutation_p.S672F|UBTF_uc010czs.2_Missense_Mutation_p.S709F|UBTF_uc002igd.2_Missense_Mutation_p.S672F|UBTF_uc010czt.2_Missense_Mutation_p.S709F	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	709	Asp/Glu/Ser-rich (acidic).				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGACTCAGAGGAGTCGCCGCC	0.468													17	27					0	0	0	0	A	42284865	A	A	42284865	3	1	278	1	0	0	0	0	1	0	0	0	16977	1174	41	2	176	2	UBTF	17	42284865	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	1027982	42284865	38910345	94	52194											
ITGB3	3690	broad.mit.edu	37	chr17	45360736	45360736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaggccctgcctctgggctCacctcgctgtgacctgaagg	6	8	12	15	1	2	2	1	2	1	0	3	2	2	2	4	3	1	2	4	3	1	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:45360736C>T	uc002ilj.2	+	3	202	c.182C>T	c.(181-183)TCA>TTA	p.S61L	ITGB3_uc002ili.1_Missense_Mutation_p.S61L|ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	61	Extracellular (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	CCTCTGGGCTCACCTCGCTGT	0.567													21	38					0	0	0	0	T	45360736	T	T	45360736	3	4	278	1	0	0	0	0	1	0	0	0	7934	838	29	2	192	2	ITGB3	17	45360736	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	3075871	45360736	35834474	95	52195											
IGF2BP1	10642	broad.mit.edu	37	chr17	47076479	47076479	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaatctttagggaaagtaGaattacaaggaaaacgctta	17	12	8	4	1	1	1	0	0	1	1	1	3	1	3	0	2	2	2	0	2	10	7			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:47076479G>C	uc002iom.2	+	2	518	c.184G>C	c.(184-186)GAA>CAA	p.E62Q	IGF2BP1_uc010dbj.2_Missense_Mutation_p.E62Q	NM_006546	NP_006537	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding	62	RRM 1.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			kidney(1)	1						AGGGAAAGTAGAATTACAAGG	0.468													6	28					0	0	0	0	C	47076479	C	C	47076479	3	2	278	1	0	0	0	0	1	0	0	0	7612	943	33	2	190	2	IGF2BP1	17	47076479	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	1715743	47076479	34118731	96	52196											
MKS1	54903	broad.mit.edu	37	chr17	56291137	56291137	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctcctcacctgtagggtccTttgaggcccgtgaagtcagg	6	11	12	12	1	3	2	2	2	1	0	5	2	4	2	4	3	0	1	4	3	2	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:56291137T>C	uc002ivr.1	-	7	813	c.738A>G	c.(736-738)AAA>AAG	p.K246K	MKS1_uc010wnq.1_Silent_p.K43K|MKS1_uc002ivs.1_Silent_p.K246K	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	246					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1						TGTAGGGTCCTTTGAGGCCCG	0.473													32	65					0	0	0	0	C	56291137	C	C	56291137	2	2	278	1	0	0	0	0	0	0	0	1	9662	1606	56	5		5	MKS1	17	56291137	Silent	SNP	T	TCGA-D6-6823-01A-11D-1912-08	9214658	56291137	24904073	97	52197											
TTYH2	94015	broad.mit.edu	37	chr17	72246094	72246094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccctgaccaccttccagcGcgcacttaccaccatgcaga	10	6	7	18	2	0	2	0	1	0	1	1	3	1	2	6	0	3	2	6	0	1	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr17:72246094G>A	uc002jkc.2	+	9	981	c.950G>A	c.(949-951)CGC>CAC	p.R317H	TTYH2_uc010wqw.1_Missense_Mutation_p.R296H|TTYH2_uc002jkd.2_5'UTR	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	317	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						ACCTTCCAGCGCGCACTTACC	0.642													21	83					0	0	0	0	A	72246094	A	A	72246094	3	1	278	1	0	0	0	0	1	0	0	0	16808	1087	38	1	984	1	TTYH2	17	72246094	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	15954957	72246094	8949116	98	52198											
CETN1	1068	broad.mit.edu	37	chr18	580762	580762	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctttgatgacgatgagacCgggaagatctcgttcaaaaa	13	10	10	8	3	3	4	1	3	2	2	4	7	3	5	1	1	0	1	1	1	3	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr18:580762C>T	uc002kko.1	+	1	396	c.354C>T	c.(352-354)ACC>ACT	p.T118T		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	118	EF-hand 3.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2						ACGATGAGACCGGGAAGATCT	0.537													23	39					0	0	0	0	T	580762	T	T	580762	2	4	278	1	0	0	0	0	0	0	0	1	3289	639	23	1		1	CETN1	18	580762	Silent	SNP	C	TCGA-D6-6823-01A-11D-1912-08		580762	77496486	99	52199											
C18orf1	753	broad.mit.edu	37	chr18	13621135	13621135	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcggagctggagttcgcccaAatcatcatcatcgtcgtggt	8	10	12	11	4	3	0	3	0	0	0	6	2	3	2	1	3	1	2	1	3	1	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr18:13621135A>C	uc002ksa.2	+	5	869	c.201A>C	c.(199-201)CAA>CAC	p.Q67H	C18orf1_uc002ksb.2_Missense_Mutation_p.Q67H|C18orf1_uc002kse.2_Missense_Mutation_p.Q30H|C18orf1_uc002ksf.2_Missense_Mutation_p.Q30H|C18orf1_uc002ksg.1_5'UTR|C18orf1_uc002ksh.1_Missense_Mutation_p.Q9H|C18orf1_uc002ksi.1_Missense_Mutation_p.Q9H	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	67	Helical; (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		AGTTCGCCCAAATCATCATCA	0.602													47	95					0	0	0	0	C	13621135	C	C	13621135	3	2	278	1	0	0	0	0	1	0	0	0	1903	11	1	5	292	5	C18orf1	18	13621135	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	13040373	13621135	64456113	100	52200											
ZNF556	80032	broad.mit.edu	37	chr19	2877900	2877900	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcacaacggggagaaaccctAtaagtgtggaaaatgcggga	15	6	13	7	2	1	1	1	0	0	1	1	4	1	3	1	4	3	0	1	4	6	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:2877900A>G	uc002lwp.1	+	4	1031	c.944A>G	c.(943-945)TAT>TGT	p.Y315C	ZNF556_uc002lwq.2_Missense_Mutation_p.Y314C	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	315	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGAAACCCTATAAGTGTGGA	0.527													6	36					0	0	0	0	G	2877900	G	G	2877900	3	3	278	1	0	0	0	0	1	0	0	0	18054	449	16	5	958	5	ZNF556	19	2877900	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08		2877900	56251083	101	52201											
TLE2	7089	broad.mit.edu	37	chr19	3002388	3002388	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggacagcacgcagctctcGtggaggtgcagctggtattt	8	9	15	9	2	1	0	0	0	1	0	2	2	1	2	0	4	4	6	0	4	1	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:3002388G>C	uc002lww.2	-	18	2273	c.2010C>G	c.(2008-2010)CAC>CAG	p.H670Q	TLE2_uc010xhb.1_Missense_Mutation_p.H337Q|TLE2_uc010dth.2_Missense_Mutation_p.H671Q|TLE2_uc010xhc.1_Missense_Mutation_p.H548Q|TLE2_uc010dti.2_Missense_Mutation_p.H684Q	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	670	WD 5.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCAGCTCTCGTGGAGGTGCA	0.612													7	27					0	0	0	0	C	3002388	C	C	3002388	3	2	278	1	0	0	0	0	1	0	0	0	16005	1136	40	3	233	3	TLE2	19	3002388	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	124488	3002388	56126595	102	52202											
C3	718	broad.mit.edu	37	chr19	6697422	6697422	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacagcagccttgacttccActtcctgcaggccggtcttt	7	11	9	14	1	1	2	0	1	1	1	3	2	3	2	4	2	3	2	4	2	0	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:6697422A>G	uc002mfm.2	-	21	2791	c.2729T>C	c.(2728-2730)GTG>GCG	p.V910A		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	910					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTTGACTTCCACTTCCTGCAG	0.567													29	57					0	0	0	0	G	6697422	G	G	6697422	3	3	278	1	0	0	0	0	1	0	0	0	2214	159	6	5	2346	5	C3	19	6697422	Missense_Mutation	SNP	A	TCGA-D6-6823-01A-11D-1912-08	3695034	6697422	52431561	103	52203											
ADAMTS10	81794	broad.mit.edu	37	chr19	8662012	8662012	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggtgggtgatctccagaGtgggctggggatggacagag	8	8	19	6	0	1	3	0	1	1	2	2	5	1	5	1	6	0	1	1	6	0	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:8662012G>A	uc002mkj.1	-	8	1173	c.899C>T	c.(898-900)ACT>ATT	p.T300I	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	300	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						GATCTCCAGAGTGGGCTGGGG	0.602													26	65					0	0	0	0	A	8662012	A	A	8662012	3	1	278	1	0	0	0	0	1	0	0	0	256	1029	36	4	2488	4	ADAMTS10	19	8662012	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	1964590	8662012	50466971	104	52204											
CHERP	10523	broad.mit.edu	37	chr19	16638963	16638963	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtttggtgggatctggtcGtgtggcccggggccccgggg	1	11	20	9	3	1	0	0	0	1	0	2	1	1	1	3	8	0	1	3	8	0	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:16638963G>A	uc002nei.1	-	9	1307	c.1233C>T	c.(1231-1233)CAC>CAT	p.H411H	MED26_uc002nee.2_Intron|CHERP_uc010xpg.1_5'Flank	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	411	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GGATCTGGTCGTGTggcccgg	0.532													27	71					0	0	0	0	A	16638963	A	A	16638963	2	1	278	1	0	0	0	0	0	0	0	1	3351	1136	40	1		1	CHERP	19	16638963	Silent	SNP	G	TCGA-D6-6823-01A-11D-1912-08	7976951	16638963	42490020	105	52205											
ZNF567	163081	broad.mit.edu	37	chr19	37210259	37210259	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actccagcacagtcatttggAtataatgactgtgagaaatc	14	11	8	8	0	1	2	1	2	0	1	3	4	2	3	1	1	1	1	1	1	3	3			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:37210259A>G	uc010xtl.1	+	6	855	c.633A>G	c.(631-633)GGA>GGG	p.G211G	ZNF567_uc002oeo.1_Silent_p.G211G|ZNF567_uc010xtk.1_Silent_p.G211G|ZNF567_uc002oep.3_Silent_p.G180G|ZNF567_uc002oeq.1_Silent_p.G180G	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	211	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGTCATTTGGATATAATGACT	0.368													16	29					0	0	0	0	G	37210259	G	G	37210259	2	3	278	1	0	0	0	0	0	0	0	1	18065	320	12	5		5	ZNF567	19	37210259	Silent	SNP	A	TCGA-D6-6823-01A-11D-1912-08	20571296	37210259	21918724	106	52206											
LRFN1	57622	broad.mit.edu	37	chr19	39804929	39804929	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atccagcgtcccgtccccccGgacccgggtccggctggagt	4	6	13	18	5	0	0	0	0	0	0	4	2	4	2	7	4	1	1	7	4	0	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:39804929G>A	uc002okw.2	-	1	1048	c.1048C>T	c.(1048-1050)CGG>TGG	p.R350W		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	350	Ig-like.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CCGTCCCCCCGGACCCGGGTC	0.692													9	13					0	0	0	0	A	39804929	A	A	39804929	3	1	278	1	0	0	0	0	1	0	0	0	8987	1115	39	1	1275	1	LRFN1	19	39804929	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	2594670	39804929	19324054	107	52207											
ZNF546	339327	broad.mit.edu	37	chr19	40520758	40520758	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtgagaaaccctacatatgTaacgaatgtggaaaagcctt	15	9	10	7	1	0	1	0	1	0	1	0	4	0	2	2	2	4	1	2	2	7	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:40520758T>C	uc002oms.2	+	7	1837	c.1581T>C	c.(1579-1581)TGT>TGC	p.C527C	ZNF546_uc002omt.2_Silent_p.C501C	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	527	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CCTACATATGTAACGAATGTG	0.403													23	41					0	0	0	0	C	40520758	C	C	40520758	2	2	278	1	0	0	0	0	0	0	0	1	18045	1644	57	5		5	ZNF546	19	40520758	Silent	SNP	T	TCGA-D6-6823-01A-11D-1912-08	715829	40520758	18608225	108	52208											
ZNF816A	125893	broad.mit.edu	37	chr19	53454451	53454451	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcctacaagaaattctttGggattctgaagctgaggaag	13	10	12	6	0	2	3	0	2	2	1	2	6	2	5	1	2	3	1	1	2	5	4			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:53454451G>C	uc002qal.1	-	5	878	c.577C>G	c.(577-579)CAA>GAA	p.Q193E	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.Q177E	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		GAAATTCTTTGGGATTCTGAA	0.378													31	64					0	0	0	0	C	53454451	C	C	53454451	3	2	278	1	0	0	0	0	1	0	0	0	18244	1357	47	4	1382	4	ZNF816A	19	53454451	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	12933693	53454451	5674532	109	52209											
MBOAT7	79143	broad.mit.edu	37	chr19	54692110	54692110	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcccaggtcccgaggatgGtgaccagagaatgcaaagtg	11	5	16	9	1	0	2	0	1	0	1	1	5	1	3	3	4	1	1	3	4	2	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:54692110G>T	uc002qdq.2	-	4	433	c.167C>A	c.(166-168)ACC>AAC	p.T56N	MBOAT7_uc010erg.2_5'Flank|MBOAT7_uc010yem.1_Missense_Mutation_p.T38N|MBOAT7_uc002qdr.2_Missense_Mutation_p.T56N|MBOAT7_uc002qds.2_Missense_Mutation_p.H25Q|MBOAT7_uc010yen.1_Missense_Mutation_p.H25Q|MBOAT7_uc002qdt.3_Missense_Mutation_p.T56N|TSEN34_uc010yeo.1_5'Flank|TSEN34_uc002qdu.2_5'Flank|TSEN34_uc002qdv.2_5'Flank|TSEN34_uc002qdw.2_5'Flank	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	56	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCCGAGGATGGTGACCAGAGA	0.642													21	37					8.04996e-18	4.54433e-17	1	0	T	54692110	T	T	54692110	3	4	278	1	0	0	0	0	1	0	0	0	9411	1261	44	4	1279	4	MBOAT7	19	54692110	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08	1237659	54692110	4436873	110	52210											
MZF1	7593	broad.mit.edu	37	chr19	59073795	59073796	+	Frame_Shift_Ins	INS	-	C	C																															ttttcgccggtgtgtgtcctINSctgatgacgcgtgagcttga																										TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr19:59073795_59073796insC	uc002qto.2	-	6	2409_2410	c.1848_1849insG	c.(1846-1851)CAGAGGfs	p.Q616fs	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Frame_Shift_Ins_p.Q616fs	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	616_617	C2H2-type 9.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		GTGTGTGTCCTCTGATGACGCG	0.663													---	---	---								C	59073796	C	C	59073795	7	5	278	1	0	1	1	0	0	0	0	0	10161	1550	54	0	359	0	MZF1	19	59073795	Frame_Shift_Ins	INS	-	TCGA-D6-6823-01A-11D-1912-08	4381685	59073795	55188	111	52211											
CDH26	60437	broad.mit.edu	37	chr20	58560126	58560126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtcactgtcatccacgaccaCcgttcacgtggatgtgcaag	9	9	10	13	3	3	0	3	0	0	0	4	2	4	1	3	1	1	2	3	1	1	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr20:58560126C>T	uc002ybe.2	+	7	1079	c.779C>T	c.(778-780)ACC>ATC	p.T260I	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	260	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TCCACGACCACCGTTCACGTG	0.547													8	42					0	0	0	0	T	58560126	T	T	58560126	3	4	278	1	0	0	0	0	1	0	0	0	3125	507	18	4	805	4	CDH26	20	58560126	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08		58560126	4465394	112	52212											
KRTAP13-1	140258	broad.mit.edu	37	chr21	31768590	31768590	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcagcagacctgctgggaGcccaccagctgccagacatc	9	6	11	15	0	1	2	1	0	0	2	2	3	1	3	4	1	5	3	4	1	0	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr21:31768590G>T	uc002yoa.2	+	1	199	c.186G>T	c.(184-186)GAG>GAT	p.E62D		NM_181599	NP_853630	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	62	5 X 10 AA approximate repeats.|2.					intermediate filament		p.E62D(1)		ovary(1)	1						CCTGCTGGGAGCCCACCAGCT	0.612													19	43					1.33834e-09	7.09724e-09	1	0	T	31768590	T	T	31768590	3	4	278	1	0	0	0	0	1	0	0	0	8561	962	34	4	188	4	KRTAP13-1	21	31768590	Missense_Mutation	SNP	G	TCGA-D6-6823-01A-11D-1912-08		31768590	16361305	113	52213											
PRDM15	63977	broad.mit.edu	37	chr21	43279700	43279700	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gagctcacggcggtcactcaCcttgccctgcttaacacaaa	10	8	8	15	2	3	0	3	0	0	0	3	1	3	0	2	2	4	2	2	2	2	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr21:43279700C>A	uc002yzq.1	-	9	1142	c.1031_splice	c.e9+1	p.R344_splice	PRDM15_uc002yzo.2_Splice_Site_p.R81_splice|PRDM15_uc002yzp.2_Splice_Site_p.R81_splice|PRDM15_uc002yzr.1_Splice_Site_p.R81_splice	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGGTCACTCACCTTGCCCTGC	0.612													10	12					3.86212e-05	0.000194495	1	0	A	43279700	A	A	43279700	5	1	278	1	0	0	0	0	0	0	1	0	12518	521	18	4	3583	4	PRDM15	21	43279700	Splice_Site	SNP	C	TCGA-D6-6823-01A-11D-1912-08	11511110	43279700	4850195	114	52214											
SCARF2	91179	broad.mit.edu	37	chr22	20781751	20781752	+	Frame_Shift_Ins	INS	-	GGACC	GGACC																															gaggagaaggaggcccgagaINSggaccaggatggtgagggct																										TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr22:20781751_20781752insGGACC	uc002zsj.1	-	10	1746_1747	c.1641_1642insGGTCC	c.(1639-1644)TCCTCTfs	p.S547fs	SCARF2_uc002zsk.1_Frame_Shift_Ins_p.S542fs	NM_153334	NP_699165	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2 isoform 1	542_543	Cytoplasmic (Potential).				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GAGGCCCGAGAGGACCAGGATG	0.599													---	---	---								GGACC	20781752	GGACC	GGACC	20781751	7	5	278	1	0	1	1	0	0	0	0	0	13949	304	11	0	978	0	SCARF2	22	20781751	Frame_Shift_Ins	INS	-	TCGA-D6-6823-01A-11D-1912-08		20781751	30522815	115	52215											
TFIP11	24144	broad.mit.edu	37	chr22	26902303	26902303	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgaggccccgtccagggacGtagcccatcttctgaagaag	9	6	12	14	3	2	2	0	1	2	1	3	4	3	3	5	2	1	1	5	2	3	2			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr22:26902303G>A	uc003acr.2	-	5	860	c.486C>T	c.(484-486)TAC>TAT	p.Y162Y	TFIP11_uc003acs.2_Silent_p.Y162Y|TFIP11_uc003act.2_Silent_p.Y162Y	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	162	G-patch.				biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						GTCCAGGGACGTAGCCCATCT	0.527													14	86					0	0	0	0	A	26902303	A	A	26902303	2	1	278	1	0	0	0	0	0	0	0	1	15873	1140	40	1		1	TFIP11	22	26902303	Silent	SNP	G	TCGA-D6-6823-01A-11D-1912-08	6120552	26902303	24402263	116	52216											
FBLN1	2192	broad.mit.edu	37	chr22	45944530	45944530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcccaccgggggccacatCtgctcctaccgctgcatcaa	7	7	9	18	2	2	0	1	0	1	0	3	0	3	0	5	2	4	3	5	2	2	1			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chr22:45944530C>G	uc003bgj.1	+	13	1626	c.1479C>G	c.(1477-1479)ATC>ATG	p.I493M	FBLN1_uc003bgg.1_Missense_Mutation_p.I493M|FBLN1_uc003bgh.2_Missense_Mutation_p.I493M|FBLN1_uc010gzz.2_Missense_Mutation_p.I531M|FBLN1_uc003bgi.1_Missense_Mutation_p.I493M	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	493	EGF-like 8; calcium-binding.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GGGGCCACATCTGCTCCTACC	0.652													13	38					0	0	0	0	G	45944530	G	G	45944530	3	3	278	1	0	0	0	0	1	0	0	0	5730	903	32	2	1529	2	FBLN1	22	45944530	Missense_Mutation	SNP	C	TCGA-D6-6823-01A-11D-1912-08	19042227	45944530	5360036	117	52217											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29973844	29973844	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagcggccacagacaaaatcGagcagggagcagaatccaga	16	2	12	11	2	0	3	0	0	0	3	2	5	1	4	2	2	3	2	2	2	3	0			TCGA-D6-6823-01A-11D-1912-08	TCGA-D6-6823-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	e1f4d8ef-f24a-417b-bf22-c03cdb6b5275	be1499ee-5b0d-4f5e-bac3-c6f6c552f4a6	g.chrX:29973844G>A	uc004dby.2	+	11	2506	c.1998G>A	c.(1996-1998)TCG>TCA	p.S666S		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	666	Cytoplasmic (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						AGACAAAATCGAGCAGGGAGC	0.527													7	7					0	0	0	0	A	29973844	A	A	29973844	2	1	278	1	0	0	0	0	0	0	0	1	7700	1045	37	1		1	IL1RAPL1	23	29973844	Silent	SNP	G	TCGA-D6-6823-01A-11D-1912-08		29973844	125296716	118	52218											
LUZP1	7798	broad.mit.edu	37	chr1	23419092	23419092	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agaacagccagagtttgcagCctgagttacttgacttccgt	10	11	10	10	1	0	4	0	2	0	2	1	4	1	4	3	0	5	3	3	0	2	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:23419092C>A	uc001bgk.2	-	4	2047	c.1663G>T	c.(1663-1665)GCT>TCT	p.A555S	LUZP1_uc010odv.1_Missense_Mutation_p.A555S|LUZP1_uc001bgl.2_Missense_Mutation_p.A555S|LUZP1_uc001bgm.1_Missense_Mutation_p.A555S	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	555						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		GAGTTTGCAGCCTGAGTTACT	0.537													4	97					0.000602214	0.000774276	1	0	A	23419092	A	A	23419092	3	1	279	1	0	0	0	0	1	0	0	0	9136	739	26	4	1575	4	LUZP1	1	23419092	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08		23419092	225831529	1	52219											
EXTL1	2134	broad.mit.edu	37	chr1	26349468	26349468	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggaaccatctctgagactCatcgcaggatcctggcttcc	8	11	9	13	1	2	1	1	1	1	1	6	4	4	3	3	3	1	2	3	3	1	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:26349468C>G	uc001blf.2	+	1	1198	c.331C>G	c.(331-333)CAT>GAT	p.H111D		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	111	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTGAGACTCATCGCAGGAT	0.577													5	58					0	0	0	0	G	26349468	G	G	26349468	3	3	279	1	0	0	0	0	1	0	0	0	5350	826	29	2	333	2	EXTL1	1	26349468	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	2930376	26349468	222901153	2	52220											
GBP4	115361	broad.mit.edu	37	chr1	89655859	89655859	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggagcctcagttgctgggcCatctgctggctatagtggtc	5	11	15	10	0	2	0	1	0	1	0	3	1	2	1	2	4	3	4	2	4	2	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:89655859C>G	uc001dnb.2	-	7	1175	c.1059G>C	c.(1057-1059)ATG>ATC	p.M353I		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	353						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		GTTGCTGGGCCATCTGCTGGC	0.602													4	57					0	0	0	0	G	89655859	G	G	89655859	3	3	279	1	0	0	0	0	1	0	0	0	6311	594	21	4	883	4	GBP4	1	89655859	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	63306391	89655859	159594762	3	52221											
DENND2D	79961	broad.mit.edu	37	chr1	111742266	111742266	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgggaaattggtaggtgatTataggctcgtaatcatcctc	10	14	11	6	1	1	1	1	1	0	0	4	2	2	2	1	4	0	3	1	4	5	6			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:111742266T>C	uc001eak.1	-	2	422	c.222A>G	c.(220-222)ATA>ATG	p.I74M	DENND2D_uc001eal.1_Missense_Mutation_p.I71M	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	74	UDENN.									ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		GGTAGGTGATTATAGGCTCGT	0.522													11	156					0	0	0	0	C	111742266	C	C	111742266	3	2	279	1	0	0	0	0	1	0	0	0	4453	1744	61	5	1237	5	DENND2D	1	111742266	Missense_Mutation	SNP	T	TCGA-D6-6824-01A-11D-1912-08	22086407	111742266	137508355	4	52222											
SPTA1	6708	broad.mit.edu	37	chr1	158627412	158627412	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattttgtcgcctagcagctCgagcacggagagactccata	10	9	10	12	3	0	1	0	0	0	1	3	4	1	2	2	1	3	3	2	1	2	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:158627412C>A	uc001fst.1	-	19	2859	c.2660G>T	c.(2659-2661)CGA>CTA	p.R887L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	887	Spectrin 9.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCTAGCAGCTCGAGCACGGAG	0.473													6	140					0.00198382	0.00243469	1	0	A	158627412	A	A	158627412	3	1	279	1	0	0	0	0	1	0	0	0	15182	884	31	3	4735	3	SPTA1	1	158627412	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	46885146	158627412	90623209	5	52223											
ATF6	22926	broad.mit.edu	37	chr1	161928411	161928411	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccacagaggcaacccaCgttgtcagcaccatccctga	11	5	9	16	1	1	2	1	1	0	1	2	2	2	2	4	1	3	4	4	1	1	1			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:161928411C>G	uc001gbr.2	+	16	2047	c.1980C>G	c.(1978-1980)CAC>CAG	p.H660Q	ATF6_uc001gbs.2_RNA	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	660	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			AGGCAACCCACGTTGTCAGCA	0.522													5	112					0	0	0	0	G	161928411	G	G	161928411	3	3	279	1	0	0	0	0	1	0	0	0	1086	535	19	3	2042	3	ATF6	1	161928411	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	3300999	161928411	87322210	6	52224											
RYR2	6262	broad.mit.edu	37	chr1	237777923	237777923	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctataccctgctgatcatggGcatctttcacaacgaggact	10	11	8	12	1	3	1	2	1	1	0	3	3	3	2	1	2	3	2	1	2	3	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:237777923G>C	uc001hyl.1	+	37	5615	c.5495G>C	c.(5494-5496)GGC>GCC	p.G1832A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1832	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGATCATGGGCATCTTTCAC	0.502													5	160					0	0	0	0	C	237777923	C	C	237777923	3	2	279	1	0	0	0	0	1	0	0	0	13834	1203	42	4	5641	4	RYR2	1	237777923	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	75849512	237777923	11472698	7	52225											
TRIM58	25893	broad.mit.edu	37	chr1	248023998	248023998	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggaggccaacgtggggaaaaAgactgtcatttggaaggtaa	14	7	15	5	1	1	1	1	0	0	1	1	4	1	4	1	6	1	1	1	6	5	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:248023998A>G	uc001ido.2	+	2	548	c.500A>G	c.(499-501)AAG>AGG	p.K167R		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	167						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GTGGGGAAAAAGACTGTCATT	0.478													5	72					0	0	0	0	G	248023998	G	G	248023998	3	3	279	1	0	0	0	0	1	0	0	0	16598	72	3	5	506	5	TRIM58	1	248023998	Missense_Mutation	SNP	A	TCGA-D6-6824-01A-11D-1912-08	10246075	248023998	1226623	8	52226											
OR2L8	391190	broad.mit.edu	37	chr1	248112599	248112599	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgctgatgataacagggtCttggatcataggctcgatca	10	12	12	7	1	3	2	2	2	1	0	4	4	3	3	0	3	2	2	0	3	2	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:248112599C>T	uc001idt.1	+	1	440	c.440C>T	c.(439-441)TCT>TTT	p.S147F	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ATAACAGGGTCTTGGATCATA	0.438													8	167					0	0	0	0	T	248112599	T	T	248112599	3	4	279	1	0	0	0	0	1	0	0	0	11063	913	32	2	442	2	OR2L8	1	248112599	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	88601	248112599	1138022	9	52227											
BOLA3	388962	broad.mit.edu	37	chr2	74362737	74362737	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtcagcgtttggggacagAggtaaatatccgcaatccat	11	10	12	8	2	1	1	1	0	0	1	3	2	3	2	2	4	1	3	2	4	4	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:74362737A>G	uc002skc.1	-	4	345	c.307T>C	c.(307-309)TCT>CCT	p.S103P	BOLA3_uc002skd.1_Missense_Mutation_p.L73P	NM_212552	NP_997717	Q53S33	BOLA3_HUMAN	bolA-like 3 isoform 1	103						extracellular region					0						TTGGGGACAGAGGTAAATATC	0.428													3	67					0	0	0	0	G	74362737	G	G	74362737	3	3	279	1	0	0	0	0	1	0	0	0	1491	304	11	5	91	5	BOLA3	2	74362737	Missense_Mutation	SNP	A	TCGA-D6-6824-01A-11D-1912-08		74362737	168836636	10	52228											
CD8A	925	broad.mit.edu	37	chr2	87013080	87013080	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggctgggcttgtctcccGatttgaccacaggcctgaaa	10	9	11	11	1	1	2	0	2	1	0	2	3	1	2	3	3	0	2	3	3	2	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:87013080G>T	uc002srt.2	-	6	1560	c.671C>A	c.(670-672)TCG>TAG	p.S224*	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Nonsense_Mutation_p.S224*|CD8A_uc010ytn.1_Nonsense_Mutation_p.S265*|CD8A_uc002sru.2_Nonsense_Mutation_p.S187*	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	224	Cytoplasmic (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						CTTGTCTCCCGATTTGACCAC	0.547													7	163					5.18039e-06	6.99353e-06	1	0	T	87013080	T	T	87013080	4	4	279	1	0	0	0	0	0	1	0	0	3059	1059	37	3	40	3	CD8A	2	87013080	Nonsense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	12650343	87013080	156186293	11	52229											
THSD7B	80731	broad.mit.edu	37	chr2	137928343	137928343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggcagcgccatgtcctcatgGaatctacagggcctgcaggg	8	7	14	12	1	2	0	1	0	1	0	3	1	3	1	3	4	3	2	3	4	2	1			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:137928343G>A	uc002tva.1	+	6	1465	c.1465G>A	c.(1465-1467)GAA>AAA	p.E489K	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.E379K	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGTCCTCATGGAATCTACAGG	0.473													4	60					0	0	0	0	A	137928343	A	A	137928343	3	1	279	1	0	0	0	0	1	0	0	0	15946	1175	41	2	1487	2	THSD7B	2	137928343	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	50915263	137928343	105271030	12	52230											
FAP	2191	broad.mit.edu	37	chr2	163039967	163039967	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcatcaatgaaacccattTctatgaattttctaaagtaa	15	16	3	7	0	4	2	2	2	2	0	4	2	4	2	1	0	1	1	1	0	7	7			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:163039967T>G	uc002ucd.2	-	21	2034	c.1826A>C	c.(1825-1827)GAA>GCA	p.E609A	FAP_uc010fpc.2_Missense_Mutation_p.E158A|FAP_uc010zct.1_Missense_Mutation_p.E584A|FAP_uc010fpd.2_Missense_Mutation_p.E88A	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	609	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						GAAACCCATTTCTATGAATTT	0.284													4	81					0	0	0	0	G	163039967	G	G	163039967	3	3	279	1	0	0	0	0	1	0	0	0	5705	1783	62	5	480	5	FAP	2	163039967	Missense_Mutation	SNP	T	TCGA-D6-6824-01A-11D-1912-08	25111624	163039967	80159406	13	52231											
ATP5G3	518	broad.mit.edu	37	chr2	176043850	176043850	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcaccagaaccagccactccTactgttgcagcacctgcacc	10	6	7	18	0	0	1	0	0	0	1	1	1	1	1	6	0	6	5	6	0	2	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:176043850T>C	uc002ujz.3	-	3	519	c.249A>G	c.(247-249)GTA>GTG	p.V83V	ATP5G3_uc002uka.3_Silent_p.V83V|ATP5G3_uc002ukb.1_Silent_p.V83V	NM_001002258	NP_001002258	P48201	AT5G3_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	83	Helical; (Potential).				ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.147)			CAGCCACTCCTACTGTTGCAG	0.443													3	67					0	0	0	0	C	176043850	C	C	176043850	2	2	279	1	0	0	0	0	0	0	0	1	1157	1509	53	5		5	ATP5G3	2	176043850	Silent	SNP	T	TCGA-D6-6824-01A-11D-1912-08	13003883	176043850	67155523	14	52232											
TTN	7273	broad.mit.edu	37	chr2	179399269	179399269	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcagcattcatgatattctCaatgatctgttggttagttt	9	19	7	6	0	4	2	3	2	2	0	5	2	4	2	0	1	1	4	0	1	3	7			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:179399269C>G	uc010zfg.1	-	307	94593	c.94369G>C	c.(94369-94371)GAG>CAG	p.E31457Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E25152Q|TTN_uc010zfi.1_Missense_Mutation_p.E25085Q|TTN_uc010zfj.1_Missense_Mutation_p.E24960Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32384							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGATATTCTCAATGATCTGT	0.413													3	103					0	0	0	0	G	179399269	G	G	179399269	3	3	279	1	0	0	0	0	1	0	0	0	16803	835	29	2	5926	2	TTN	2	179399269	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	3355419	179399269	63800104	15	52233											
NDUFAF3	25915	broad.mit.edu	37	chr3	49060398	49060398	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggggcattgctgtggaaGtgcaggacacggtgagtccc	8	7	17	9	2	0	1	0	1	0	0	1	3	1	3	1	5	3	3	1	5	1	1			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:49060398G>T	uc003cvq.2	+	4	931	c.427G>T	c.(427-429)GTG>TTG	p.V143L	DALRD3_uc003cvm.1_5'Flank|DALRD3_uc010hko.1_5'Flank|uc011bcb.1_5'Flank|MIR425_hsa-mir-425|MI0001448_5'Flank|NDUFAF3_uc003cvn.2_Missense_Mutation_p.V86L|uc003cvo.1_5'Flank|MIR191_hsa-mir-191|MI0000465_5'Flank|NDUFAF3_uc003cvp.2_Missense_Mutation_p.V86L|NDUFAF3_uc003cvr.2_Missense_Mutation_p.V86L|NDUFAF3_uc003cvs.2_Missense_Mutation_p.V86L	NM_199069	NP_951032	Q9BU61	NDUF3_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	143					mitochondrial respiratory chain complex I assembly	mitochondrial inner membrane|nucleus	protein binding				0						TGCTGTGGAAGTGCAGGACAC	0.637													4	95					0.00024832	0.000327056	1	0	T	49060398	T	T	49060398	3	4	279	1	0	0	0	0	1	0	0	0	10330	1029	36	4	441	4	NDUFAF3	3	49060398	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08		49060398	148962032	16	52234											
CPOX	1371	broad.mit.edu	37	chr3	98304334	98304334	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcctggggggtgaatgagtCatcacagtgctttttcacaa	9	12	11	9	0	3	2	3	2	0	0	4	2	4	2	1	3	1	1	1	3	2	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:98304334C>T	uc003dsx.2	-	5	1216	c.1123G>A	c.(1123-1125)GAC>AAC	p.D375N		NM_000097	NP_000088	P36551	HEM6_HUMAN	coproporphyrinogen oxidase precursor	375						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity				0						GTGAATGAGTCATCACAGTGC	0.517													7	234					0	0	0	0	T	98304334	T	T	98304334	3	4	279	1	0	0	0	0	1	0	0	0	3836	826	29	2	253	2	CPOX	3	98304334	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	49243936	98304334	99718096	17	52235											
PIK3CA	5290	broad.mit.edu	37	chr3	178947827	178947827	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgacctgtttacacgttcatGtgctggatactgtgtagcta	8	15	10	8	1	1	1	1	1	0	0	1	2	1	2	1	1	4	5	1	1	4	6			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:178947827G>T	uc003fjk.2	+	19	2859	c.2702G>T	c.(2701-2703)TGT>TTT	p.C901F		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	901	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.C901F(3)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACACGTTCATGTGCTGGATAC	0.388		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			16	174					2.48551e-13	3.48616e-13	1	0	T	178947827	T	T	178947827	3	4	279	1	0	0	0	0	1	0	0	0	11968	1377	48	4	2772	4	PIK3CA	3	178947827	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	80643493	178947827	19074603	18	52236											
SENP5	205564	broad.mit.edu	37	chr3	196612189	196612189	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgaaagctaagctgggaaGgccagttacttggaatagac	13	9	12	7	0	1	2	0	1	1	1	1	4	1	4	1	3	3	3	1	3	6	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:196612189G>A	uc003fwz.3	+	2	386	c.137G>A	c.(136-138)AGG>AAG	p.R46K	SENP5_uc011bty.1_Missense_Mutation_p.R46K	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	46					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AAGCTGGGAAGGCCAGTTACT	0.413													4	46					0	0	0	0	A	196612189	A	A	196612189	3	1	279	1	0	0	0	0	1	0	0	0	14114	1000	35	4	139	4	SENP5	3	196612189	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	17664362	196612189	1410241	19	52237											
USP53	54532	broad.mit.edu	37	chr4	120169908	120169908	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttgtcgattcccagacgatAtttgcacagttccaacacag	11	11	7	12	2	0	1	0	0	0	1	3	3	2	1	2	0	2	2	2	0	2	5			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr4:120169908A>G	uc003ics.3	+	6	1309	c.243A>G	c.(241-243)ATA>ATG	p.I81M	USP53_uc003icr.3_Missense_Mutation_p.I81M|USP53_uc003icu.3_Translation_Start_Site	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	81					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						CCCAGACGATATTTGCACAGT	0.378													4	49					0	0	0	0	G	120169908	G	G	120169908	3	3	279	1	0	0	0	0	1	0	0	0	17152	439	16	5	253	5	USP53	4	120169908	Missense_Mutation	SNP	A	TCGA-D6-6824-01A-11D-1912-08		120169908	70984368	20	52238											
RAB33B	83452	broad.mit.edu	37	chr4	140394046	140394046	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttggaaataaatgtgacttGagaagtgccatacaggtacc	14	10	11	6	0	0	2	0	2	0	1	0	4	0	3	2	2	3	2	2	2	6	5			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr4:140394046G>C	uc003ihv.2	+	2	845	c.456G>C	c.(454-456)TTG>TTC	p.L152F		NM_031296	NP_112586	Q9H082	RB33B_HUMAN	RAB33B, member RAS oncogene family	152					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding				0	all_hematologic(180;0.162)					AATGTGACTTGAGAAGTGCCA	0.398													4	126					0	0	0	0	C	140394046	C	C	140394046	3	2	279	1	0	0	0	0	1	0	0	0	12988	1281	45	2	462	2	RAB33B	4	140394046	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	20224138	140394046	50760230	21	52239											
DCHS2	54798	broad.mit.edu	37	chr4	155278384	155278384	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctctacttgaagtgccttaGcagaggtaaaaacatctcta	13	11	7	10	0	2	2	0	1	2	1	3	2	2	2	2	1	4	2	2	1	7	5			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr4:155278384G>C	uc003inw.2	-	6	787	c.787C>G	c.(787-789)CTA>GTA	p.L263V	DCHS2_uc003inx.2_Intron	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	263	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		aagtgccttagcagaggtaaa	0													11	136					0	0	0	0	C	155278384	C	C	155278384	3	2	279	1	0	0	0	0	1	0	0	0	4305	962	34	4	8139	4	DCHS2	4	155278384	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	14884338	155278384	35875892	22	52240											
PCDHB2	56133	broad.mit.edu	37	chr5	140476001	140476001	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagaccgcggctccccggcgTtgagcagcgaggcgctggtg	5	5	17	14	6	0	2	0	1	0	1	1	3	1	2	3	4	2	4	3	4	0	1			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr5:140476001T>C	uc003lil.2	+	1	1765	c.1627T>C	c.(1627-1629)TTG>CTG	p.L543L	PCDHB2_uc003lim.1_Silent_p.L204L	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	543	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCCCGGCGTTGAGCAGCGA	0.706													6	89					0	0	0	0	C	140476001	C	C	140476001	2	2	279	1	0	0	0	0	0	0	0	1	11596	1722	60	5		5	PCDHB2	5	140476001	Silent	SNP	T	TCGA-D6-6824-01A-11D-1912-08		140476001	40439259	23	52241											
PCDHGA4	56111	broad.mit.edu	37	chr5	140734835	140734835	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgccttctcctgggggttcTggtggaaatcagggccgaac	6	10	14	11	1	3	0	1	0	2	0	4	2	3	1	3	5	2	1	3	5	2	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr5:140734835T>C	uc003ljq.1	+	1	68	c.68T>C	c.(67-69)CTG>CCG	p.L23P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.L23P	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	23					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGGGGTTCTGGTGGAAATC	0.637													6	73					0	0	0	0	C	140734835	C	C	140734835	3	2	279	1	0	0	0	0	1	0	0	0	11610	1580	55	5	70	5	PCDHGA4	5	140734835	Missense_Mutation	SNP	T	TCGA-D6-6824-01A-11D-1912-08	258834	140734835	40180425	24	52242											
ADAM19	8728	broad.mit.edu	37	chr5	156934137	156934137	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgatggtggtgccgtggAaggacatgcccctgcaggag	7	6	18	10	2	0	0	0	0	0	0	0	4	0	3	4	6	3	1	4	6	1	0			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr5:156934137A>G	uc003lwz.2	-	10	981	c.917T>C	c.(916-918)TTC>TCC	p.F306S	ADAM19_uc003lww.1_Missense_Mutation_p.F39S|ADAM19_uc011ddr.1_Missense_Mutation_p.F237S	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	306	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTGCCGTGGAAGGACATGCC	0.617													3	80					0	0	0	0	G	156934137	G	G	156934137	3	3	279	1	0	0	0	0	1	0	0	0	240	246	9	5	1895	5	ADAM19	5	156934137	Missense_Mutation	SNP	A	TCGA-D6-6824-01A-11D-1912-08	16199302	156934137	23981123	25	52243											
RIMS1	22999	broad.mit.edu	37	chr6	72968708	72968708	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggagtttagatgaaattcatCcaacaagaaggtcacgttct	14	11	9	7	1	3	3	2	1	1	2	4	4	4	4	1	2	1	2	1	2	5	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr6:72968708C>T	uc003pga.2	+	18	3024	c.2947C>T	c.(2947-2949)CCA>TCA	p.P983S	RIMS1_uc011dyb.1_Missense_Mutation_p.P608S|RIMS1_uc003pgc.2_Missense_Mutation_p.P609S|RIMS1_uc010kaq.2_Missense_Mutation_p.P456S|RIMS1_uc011dyc.1_Missense_Mutation_p.P457S|RIMS1_uc010kar.2_Missense_Mutation_p.P376S|RIMS1_uc011dyd.1_Missense_Mutation_p.P442S|RIMS1_uc003pgf.2_Missense_Mutation_p.P199S|RIMS1_uc003pgg.2_Missense_Mutation_p.P200S|RIMS1_uc003pgi.2_Missense_Mutation_p.P199S|RIMS1_uc003pgh.2_Missense_Mutation_p.P199S|RIMS1_uc003pgd.2_Missense_Mutation_p.P200S|RIMS1_uc003pge.2_Missense_Mutation_p.P200S|RIMS1_uc011dye.1_5'UTR|RIMS1_uc011dyf.1_5'Flank|RIMS1_uc003pgb.3_Missense_Mutation_p.P609S|RIMS1_uc010kas.1_Missense_Mutation_p.P442S	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	983					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TGAAATTCATCCAACAAGAAG	0.388													6	90					0	0	0	0	T	72968708	T	T	72968708	3	4	279	1	0	0	0	0	1	0	0	0	13432	855	30	2	3180	2	RIMS1	6	72968708	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08		72968708	98146359	26	52244											
C6orf174	387104	broad.mit.edu	37	chr6	127796926	127796926	+	Frame_Shift_Del	DEL	G	-	-																															gctctcggcgtcgctgtcgcGggggctgccgcggatgccca																										TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr6:127796926delG	uc003qbd.2	-	6	3110	c.2245delC	c.(2245-2247)CGCfs	p.R749fs	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	749						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TCGCTGTCGCGGGGGCTGCCG	0.692													---	---	---								-	127796926	-	-	127796926	7	5	279	1	0	1	0	1	0	0	0	0	2355	1116	39	0	606	0	C6orf174	6	127796926	Frame_Shift_Del	DEL	G	TCGA-D6-6824-01A-11D-1912-08	54828218	127796926	43318141	27	52245											
PDE1C	5137	broad.mit.edu	37	chr7	31862847	31862847	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatcgcttggcatctgacgaGctgatgctattcaaactgga	10	11	11	9	2	2	2	1	2	1	0	3	5	2	3	0	2	3	4	0	2	2	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:31862847G>A	uc003tcm.1	-	14	1891	c.1422C>T	c.(1420-1422)AGC>AGT	p.S474S	PDE1C_uc003tcn.1_Silent_p.S474S|PDE1C_uc003tco.1_Silent_p.S534S|PDE1C_uc003tcr.2_Silent_p.S474S|PDE1C_uc003tcs.2_Silent_p.S474S	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	474	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CATCTGACGAGCTGATGCTAT	0.438													4	54					0	0	0	0	A	31862847	A	A	31862847	2	1	279	1	0	0	0	0	0	0	0	1	11689	962	34	4		4	PDE1C	7	31862847	Silent	SNP	G	TCGA-D6-6824-01A-11D-1912-08		31862847	127275816	28	52246											
SEMA3C	10512	broad.mit.edu	37	chr7	80546045	80546045	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgggaagatcctttcacaCagatagaacaaataaatact	17	9	7	8	0	1	3	1	0	0	3	2	4	2	4	1	1	2	1	1	1	7	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:80546045C>T	uc003uhj.2	-	2	615	c.53G>A	c.(52-54)TGT>TAT	p.C18Y	SEMA3C_uc011kgw.1_Missense_Mutation_p.C36Y|SEMA3C_uc011kgx.1_Translation_Start_Site	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	18					immune response|response to drug	membrane	receptor activity			ovary(1)	1						TCCTTTCACACAGATAGAACA	0.348													9	54					0	0	0	0	T	80546045	T	T	80546045	3	4	279	1	0	0	0	0	1	0	0	0	14091	478	17	4	2270	4	SEMA3C	7	80546045	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	48683198	80546045	78592618	29	52247											
NPTX2	4885	broad.mit.edu	37	chr7	98254269	98254269	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agtcaccagatgcgttcaagGtgtccctcccactccgcaca	9	8	8	16	2	2	1	2	0	0	1	5	1	5	1	4	1	1	2	4	1	1	1			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:98254269G>C	uc003upl.2	+	3	856	c.679G>C	c.(679-681)GTG>CTG	p.V227L		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	227	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			TGCGTTCAAGGTGTCCCTCCC	0.607													19	226					0	0	0	0	C	98254269	C	C	98254269	3	2	279	1	0	0	0	0	1	0	0	0	10657	1261	44	4	689	4	NPTX2	7	98254269	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	17708224	98254269	60884394	30	52248											
OR9A4	130075	broad.mit.edu	37	chr7	141618783	141618783	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttctttttctacttggtGacattaatgggaaacacagt	10	17	7	7	0	3	1	0	1	3	0	3	2	3	2	0	2	2	0	0	2	3	7			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:141618783G>A	uc003vwu.1	+	1	108	c.108G>A	c.(106-108)GTG>GTA	p.V36V		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					TCTACTTGGTGACATTAATGG	0.428													6	157					0	0	0	0	A	141618783	A	A	141618783	2	1	279	1	0	0	0	0	0	0	0	1	11303	1277	45	2		2	OR9A4	7	141618783	Silent	SNP	G	TCGA-D6-6824-01A-11D-1912-08	43364514	141618783	17519880	31	52249											
CSMD1	64478	broad.mit.edu	37	chr8	4494966	4494966	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggacaactgtatcctattgCgctcgcccgtgatgatgatc	9	11	10	11	3	0	3	0	3	0	0	3	4	1	4	2	1	2	2	2	1	3	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:4494966C>G	uc011kwk.1	-	2	590	c.200G>C	c.(199-201)CGC>CCC	p.R67P		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	67	Extracellular (Potential).|CUB 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TATCCTATTGCGCTCGCCCGT	0.468													4	101					0	0	0	0	G	4494966	G	G	4494966	3	3	279	1	0	0	0	0	1	0	0	0	3961	768	27	3	10583	3	CSMD1	8	4494966	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08		4494966	141869056	32	52250											
PXDNL	137902	broad.mit.edu	37	chr8	52320759	52320759	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgtggtctctacccctttgaAtgatggtggcagccgaatcc	7	11	11	12	2	1	2	0	2	1	0	3	3	2	2	4	3	2	1	4	3	3	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:52320759A>G	uc003xqu.3	-	17	3526	c.3425T>C	c.(3424-3426)ATT>ACT	p.I1142T	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1142					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ACCCCTTTGAATGATGGTGGC	0.493													5	122					0	0	0	0	G	52320759	G	G	52320759	3	3	279	1	0	0	0	0	1	0	0	0	12913	101	4	5	994	5	PXDNL	8	52320759	Missense_Mutation	SNP	A	TCGA-D6-6824-01A-11D-1912-08	47825793	52320759	94043263	33	52251											
CSMD3	114788	broad.mit.edu	37	chr8	113249436	113249436	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacctgaaagtagcagctccAtgttgctattgctcagtgtt	9	14	9	9	0	1	1	1	1	0	0	2	1	2	1	2	0	5	7	2	0	4	6			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:113249436A>T	uc003ynu.2	-	67	10769	c.10610T>A	c.(10609-10611)ATG>AAG	p.M3537K	CSMD3_uc003yns.2_Missense_Mutation_p.M2739K|CSMD3_uc003ynt.2_Missense_Mutation_p.M3497K|CSMD3_uc011lhx.1_Missense_Mutation_p.M3368K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3537	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAGCAGCTCCATGTTGCTATT	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	94					0	0	0	0	T	113249436	T	T	113249436	3	4	279	1	0	0	0	0	1	0	0	0	3963	217	8	5	533	5	CSMD3	8	113249436	Missense_Mutation	SNP	A	TCGA-D6-6824-01A-11D-1912-08	60928677	113249436	33114586	34	52252											
CSMD3	114788	broad.mit.edu	37	chr8	113662433	113662433	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccaccagtggtttttttcGcatagaaggggctcttcatg	7	14	10	10	1	2	1	1	0	1	1	4	1	3	1	2	3	0	3	2	3	2	5			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:113662433G>T	uc003ynu.2	-	19	3309	c.3150C>A	c.(3148-3150)TGC>TGA	p.C1050*	CSMD3_uc003yns.2_Nonsense_Mutation_p.C322*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.C1010*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.C946*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1050	Extracellular (Potential).|Sushi 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTTTTTTTCGCATAGAAGGG	0.393										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	90					0.000602214	0.000774276	1	0	T	113662433	T	T	113662433	4	4	279	1	0	0	0	0	0	1	0	0	3963	1079	38	3	8185	3	CSMD3	8	113662433	Nonsense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	412997	113662433	32701589	35	52253											
SHARPIN	81858	broad.mit.edu	37	chr8	145154650	145154650	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctcctgaagctgaacactCagggccacacgatgctgggc	9	6	12	14	1	1	2	1	2	0	0	2	3	2	2	3	2	3	2	3	2	2	0			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:145154650C>G	uc003zba.2	-	4	1099	c.615G>C	c.(613-615)CTG>CTC	p.L205L	SHARPIN_uc003zbb.2_RNA	NM_030974	NP_112236	Q9H0F6	SHRPN_HUMAN	shank-interacting protein-like 1	205	Interaction with SHANK1 (By similarity).				negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			ovary(1)	1	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTGAACACTCAGGGCCACAC	0.652													3	74					0	0	0	0	G	145154650	G	G	145154650	2	3	279	1	0	0	0	0	0	0	0	1	14332	813	29	2		2	SHARPIN	8	145154650	Silent	SNP	C	TCGA-D6-6824-01A-11D-1912-08	31492217	145154650	1209372	36	52254											
ZNF658	26149	broad.mit.edu	37	chr9	40774387	40774387	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccctttcattacactcataGtgtgtcatagccatgtgaac	10	13	6	12	0	3	1	3	1	0	0	3	1	3	1	3	0	3	0	3	0	4	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:40774387G>C	uc004abs.2	-	5	1040	c.888C>G	c.(886-888)CAC>CAG	p.H296Q	ZNF658_uc010mmm.1_Missense_Mutation_p.H296Q|ZNF658_uc010mmn.1_Missense_Mutation_p.H296Q	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TACACTCATAGTGTGTCATAG	0.403													18	167					0	0	0	0	C	40774387	C	C	40774387	3	2	279	1	0	0	0	0	1	0	0	0	18136	1020	36	4	2295	4	ZNF658	9	40774387	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08		40774387	100439044	37	52255											
LPPR1	54886	broad.mit.edu	37	chr9	104075140	104075140	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccaagccggtgctgtgcCtcggaactctctgcacagcc	6	8	12	15	2	1	0	0	0	1	0	3	1	1	1	4	3	6	2	4	3	2	0			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:104075140C>A	uc004bbb.2	+	6	1096	c.697C>A	c.(697-699)CTC>ATC	p.L233I	LPPR1_uc011lvi.1_Missense_Mutation_p.L209I|LPPR1_uc004bbc.2_Missense_Mutation_p.L233I|LPPR1_uc010mtc.2_Missense_Mutation_p.L217I	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	233	Helical; (Potential).					integral to membrane	catalytic activity				0						GGTGCTGTGCCTCGGAACTCT	0.567													10	94					0.00136819	0.00169845	1	0	A	104075140	A	A	104075140	3	1	279	1	0	0	0	0	1	0	0	0	8974	681	24	4	715	4	LPPR1	9	104075140	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	63300753	104075140	37138291	38	52256											
GRIN3A	116443	broad.mit.edu	37	chr9	104448991	104448991	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggctgtggctacagctctTgcgaccagctccatagcatc	7	10	11	13	1	1	0	0	0	1	0	3	1	2	0	2	2	5	5	2	2	2	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:104448991T>G	uc004bbp.1	-	2	1792	c.1191A>C	c.(1189-1191)GCA>GCC	p.A397A	GRIN3A_uc004bbq.1_Silent_p.A397A	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	397	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CTACAGCTCTTGCGACCAGCT	0.498													14	69					0	0	0	0	G	104448991	G	G	104448991	2	3	279	1	0	0	0	0	0	0	0	1	6822	1799	63	5		5	GRIN3A	9	104448991	Silent	SNP	T	TCGA-D6-6824-01A-11D-1912-08	373851	104448991	36764440	39	52257											
FCN1	2219	broad.mit.edu	37	chr9	137801651	137801651	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtcctggcccgtctaggcgGgccgcaccttcatctctgac	4	9	12	16	3	3	1	1	1	2	0	5	1	4	1	4	4	0	1	4	4	1	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:137801651G>T	uc004cfi.2	-	9	1066	c.974C>A	c.(973-975)CCC>CAC	p.P325H		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	325	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CGTCTAGGCGGGCCGCACCTT	0.592													8	73					0.00307968	0.00373714	1	0	T	137801651	T	T	137801651	3	4	279	1	0	0	0	0	1	0	0	0	5823	1232	43	4	10	4	FCN1	9	137801651	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	33352660	137801651	3411780	40	52258											
PARD3	56288	broad.mit.edu	37	chr10	34673066	34673066	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacacacttactgttcaaatCttctatttcgaaggtcgcca	11	13	5	12	2	3	0	1	0	2	0	5	1	3	0	1	1	1	1	1	1	4	5			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr10:34673066C>T	uc010qej.1	-	8	1007	c.1007G>A	c.(1006-1008)AGA>AAA	p.R336K	PARD3_uc010qek.1_Missense_Mutation_p.R336K|PARD3_uc010qel.1_Missense_Mutation_p.R336K|PARD3_uc010qem.1_Missense_Mutation_p.R336K|PARD3_uc010qen.1_Missense_Mutation_p.R336K|PARD3_uc010qeo.1_Missense_Mutation_p.R336K|PARD3_uc010qep.1_Missense_Mutation_p.R292K|PARD3_uc010qeq.1_Missense_Mutation_p.R292K|PARD3_uc001ixo.1_Missense_Mutation_p.R66K|PARD3_uc001ixp.1_Missense_Mutation_p.R201K|PARD3_uc001ixq.1_Missense_Mutation_p.R336K|PARD3_uc001ixr.1_Missense_Mutation_p.R336K|PARD3_uc001ixt.1_Missense_Mutation_p.R157K|PARD3_uc001ixu.1_Missense_Mutation_p.R292K|PARD3_uc001ixs.1_5'UTR	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	336	PDZ 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CTGTTCAAATCTTCTATTTCG	0.398													4	60					0	0	0	0	T	34673066	T	T	34673066	3	4	279	1	0	0	0	0	1	0	0	0	11497	913	32	2	3170	2	PARD3	10	34673066	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08		34673066	100861681	41	52259											
DRGX	644168	broad.mit.edu	37	chr10	50574313	50574313	+	Frame_Shift_Del	DEL	G	-	-																															gacagcttctgagtgctcgcGggccttcatgcgcagggtgg																										TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr10:50574313delG	uc010qgq.1	-	6	655	c.655delC	c.(655-657)CGCfs	p.R219fs		NM_001080520	NP_001073989	A6NNA5	DRGX_HUMAN	dorsal root ganglia homeobox	219					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GAGTGCTCGCGGGCCTTCATG	0.672													---	---	---								-	50574313	-	-	50574313	7	5	279	1	0	1	0	1	0	0	0	0	4785	1116	39	0	154	0	DRGX	10	50574313	Frame_Shift_Del	DEL	G	TCGA-D6-6824-01A-11D-1912-08	15901247	50574313	84960434	42	52260											
RUFY2	55680	broad.mit.edu	37	chr10	70141060	70141060	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgtcgaaggcctatcagagTatcttgtttctcatggatat	9	16	9	7	1	3	1	2	0	2	1	5	3	3	2	1	2	0	2	1	2	4	6			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr10:70141060T>C	uc001job.2	-	11	1468	c.1141A>G	c.(1141-1143)ACT>GCT	p.T381A	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Missense_Mutation_p.T312A|RUFY2_uc010qiw.1_Missense_Mutation_p.T288A|RUFY2_uc001jod.1_Missense_Mutation_p.T346A	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	395	Potential.					nucleus	metal ion binding			ovary(1)	1						CCTATCAGAGTATCTTGTTTC	0.363													9	101					0	0	0	0	C	70141060	C	C	70141060	3	2	279	1	0	0	0	0	1	0	0	0	13804	1638	57	5	929	5	RUFY2	10	70141060	Missense_Mutation	SNP	T	TCGA-D6-6824-01A-11D-1912-08	19566747	70141060	65393687	43	52261											
P2RY6	5031	broad.mit.edu	37	chr11	73008161	73008161	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcatggctctcactgtcatcGgcttcctgctgccctttgct	3	14	9	15	1	2	0	2	0	1	0	5	0	3	0	2	2	3	5	2	2	0	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr11:73008161G>T	uc001otm.2	+	4	1003	c.598G>T	c.(598-600)GGC>TGC	p.G200C	P2RY6_uc001otn.2_Missense_Mutation_p.G200C|P2RY6_uc001oto.2_Missense_Mutation_p.G200C|P2RY6_uc001otp.2_Missense_Mutation_p.G200C|P2RY6_uc001otq.2_Missense_Mutation_p.G200C|P2RY6_uc001otr.2_Missense_Mutation_p.G200C|P2RY6_uc001ots.2_Missense_Mutation_p.G200C	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	200	Helical; Name=5; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						CACTGTCATCGGCTTCCTGCT	0.657													16	174					5.03518e-11	6.97179e-11	1	0	T	73008161	T	T	73008161	3	4	279	1	0	0	0	0	1	0	0	0	11408	1116	39	3	600	3	P2RY6	11	73008161	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08		73008161	61998355	44	52262											
ARHGAP20	57569	broad.mit.edu	37	chr11	110450456	110450456	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaagcatgtgggggtggctCtaagggtccttttggagaag	9	10	17	5	0	1	2	0	0	1	2	2	3	2	2	1	5	1	2	1	5	3	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr11:110450456C>T	uc001pkz.1	-	16	3499	c.3214G>A	c.(3214-3216)GAG>AAG	p.E1072K	ARHGAP20_uc001pky.1_Missense_Mutation_p.E1049K|ARHGAP20_uc009yyb.1_Missense_Mutation_p.E1036K|ARHGAP20_uc001pla.1_Missense_Mutation_p.E1036K|ARHGAP20_uc001plb.2_Missense_Mutation_p.E615K	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1072					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GGGGGTGGCTCTAAGGGTCCT	0.498													7	159					0	0	0	0	T	110450456	T	T	110450456	3	4	279	1	0	0	0	0	1	0	0	0	870	922	32	2	365	2	ARHGAP20	11	110450456	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	37442295	110450456	24556060	45	52263											
PIWIL1	9271	broad.mit.edu	37	chr12	130831541	130831541	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatgtgaggataacgatcaCtttaacaaatgaacttccac	15	10	8	8	1	1	2	1	2	0	0	2	5	2	4	1	2	3	0	1	2	4	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr12:130831541C>A	uc001uik.2	+	6	677	c.587C>A	c.(586-588)ACT>AAT	p.T196N	PIWIL1_uc001uij.1_Missense_Mutation_p.T196N	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	196					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATAACGATCACTTTAACAAAT	0.333													5	49					0.00116845	0.00146735	1	0	A	130831541	A	A	130831541	3	1	279	1	0	0	0	0	1	0	0	0	12012	565	20	4	605	4	PIWIL1	12	130831541	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08		130831541	3020354	46	52264											
RFXAP	5994	broad.mit.edu	37	chr13	37399599	37399599	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catactctccattgttaaacAaagaacaggatcttttgggg	13	12	8	8	0	2	1	0	0	2	1	3	2	2	2	1	3	3	1	1	3	5	5			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:37399599A>C	uc001uvu.1	+	2	791	c.635A>C	c.(634-636)CAA>CCA	p.Q212P		NM_000538	NP_000529	O00287	RFXAP_HUMAN	regulatory factor X-associated protein	212						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		ATTGTTAAACAAAGAACAGGA	0.318													4	81					0	0	0	0	C	37399599	C	C	37399599	3	2	279	1	0	0	0	0	1	0	0	0	13335	130	5	5	641	5	RFXAP	13	37399599	Missense_Mutation	SNP	A	TCGA-D6-6824-01A-11D-1912-08		37399599	77770279	47	52265											
FREM2	341640	broad.mit.edu	37	chr13	39358893	39358893	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgcccatggggggaagaatCggatcagagttcccaggggc	10	6	16	9	1	1	2	1	0	0	2	3	4	2	4	2	6	1	1	2	6	2	1			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:39358893C>T	uc001uwv.2	+	6	6276	c.5967C>T	c.(5965-5967)ATC>ATT	p.I1989I	FREM2_uc001uww.2_Silent_p.I75I	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1989	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGGGAAGAATCGGATCAGAGT	0.448													4	39					0	0	0	0	T	39358893	T	T	39358893	2	4	279	1	0	0	0	0	0	0	0	1	6079	874	31	1		1	FREM2	13	39358893	Silent	SNP	C	TCGA-D6-6824-01A-11D-1912-08	1959294	39358893	75810985	48	52266											
HNRNPA1L2	144983	broad.mit.edu	37	chr13	53217477	53217477	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggaggaaattttggaggcAgaagctctggcccctatggc	10	8	15	8	0	1	1	0	0	1	1	1	4	1	4	2	6	1	2	2	6	3	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:53217477A>T	uc001vgx.1	+	7	1923	c.850A>T	c.(850-852)AGA>TGA	p.R284*	HNRNPA1L2_uc001vgy.1_Nonsense_Mutation_p.R284*|HNRNPA1L2_uc001vgz.1_Nonsense_Mutation_p.R284*	NM_001011724	NP_001011724	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like	284	Nuclear targeting sequence (By similarity).|Gly-rich.				mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding				0						TTTTGGAGGCAGAAGCTCTGG	0.418													5	101					0	0	0	0	T	53217477	T	T	53217477	4	4	279	1	0	0	0	0	0	1	0	0	7297	180	7	5	852	5	HNRNPA1L2	13	53217477	Nonsense_Mutation	SNP	A	TCGA-D6-6824-01A-11D-1912-08	13858584	53217477	61952401	49	52267											
ZNF828	283489	broad.mit.edu	37	chr13	115090169	115090169	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaggaagccatccccttcAgagtctcctgaaccttggaa	11	8	8	14	0	2	2	1	1	1	1	4	4	3	4	6	2	2	0	6	2	4	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:115090169A>T	uc010ahb.2	+	3	1181	c.852A>T	c.(850-852)TCA>TCT	p.S284S	ZNF828_uc001vuv.2_Silent_p.S284S|ZNF828_uc010tko.1_Silent_p.S284S	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	284	Mediates interaction with MAD2L2.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		CATCCCCTTCAGAGTCTCCTG	0.617													5	73					0	0	0	0	T	115090169	T	T	115090169	2	4	279	1	0	0	0	0	0	0	0	1	18248	175	7	5		5	ZNF828	13	115090169	Silent	SNP	A	TCGA-D6-6824-01A-11D-1912-08	61872692	115090169	79709	50	52268											
MYH6	4624	broad.mit.edu	37	chr14	23863348	23863348	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttctcctccagctccttgcGgcgagcctcggacttctcca	4	11	8	18	3	2	0	0	0	2	0	7	2	4	1	5	2	3	1	5	2	0	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr14:23863348G>T	uc001wjv.2	-	21	2681	c.2614C>A	c.(2614-2616)CGC>AGC	p.R872S		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	872	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		AGCTCCTTGCGGCGAGCCTCG	0.592													9	81					1.04858e-14	1.49008e-14	1	0	T	23863348	T	T	23863348	3	4	279	1	0	0	0	0	1	0	0	0	10091	1116	39	3	3281	3	MYH6	14	23863348	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08		23863348	83486192	51	52269											
NID2	22795	broad.mit.edu	37	chr14	52508964	52508964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccgtgtaggctctgccatCattgcccacgatatacgcat	8	10	10	13	3	2	0	1	0	1	0	2	1	2	0	3	2	3	3	3	2	3	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr14:52508964C>T	uc001wzo.2	-	7	1918	c.1684G>A	c.(1684-1686)GAT>AAT	p.D562N	NID2_uc010tqs.1_Missense_Mutation_p.D562N|NID2_uc010tqt.1_Missense_Mutation_p.D562N|NID2_uc001wzp.2_Missense_Mutation_p.D562N	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	562	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GCTCTGCCATCATTGCCCACG	0.597													16	198					0	0	0	0	T	52508964	T	T	52508964	3	4	279	1	0	0	0	0	1	0	0	0	10469	826	29	2	2507	2	NID2	14	52508964	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	28645616	52508964	54840576	52	52270											
FGF7	2252	broad.mit.edu	37	chr15	49776562	49776562	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aattctggaaaaccattacaAcacatatgcatcagctaaat	18	10	4	9	0	2	0	1	0	1	0	2	1	2	1	1	1	5	2	1	1	8	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:49776562A>G	uc001zxn.2	+	4	975	c.446A>G	c.(445-447)AAC>AGC	p.N149S	C15orf33_uc001zxl.2_Intron|C15orf33_uc001zxm.2_Intron	NM_002009	NP_002000	P21781	FGF7_HUMAN	fibroblast growth factor 7 precursor	149					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity				0		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	AACCATTACAACACATATGCA	0.328													3	47					0	0	0	0	G	49776562	G	G	49776562	3	3	279	1	0	0	0	0	1	0	0	0	5889	43	2	5	456	5	FGF7	15	49776562	Missense_Mutation	SNP	A	TCGA-D6-6824-01A-11D-1912-08		49776562	52754830	53	52271											
SLC24A1	9187	broad.mit.edu	37	chr15	65936825	65936825	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggccagagcccaaccccAggccaaagcagaaagcaaac	16	0	11	14	0	0	2	0	0	0	2	0	2	0	2	5	3	5	2	5	3	4	0			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:65936825A>G	uc010ujf.1	+	5	2401	c.2114A>G	c.(2113-2115)CAG>CGG	p.Q705R	SLC24A1_uc010ujd.1_Missense_Mutation_p.Q687R|SLC24A1_uc010uje.1_Missense_Mutation_p.Q687R|SLC24A1_uc010ujg.1_Missense_Mutation_p.Q705R|SLC24A1_uc010ujh.1_Missense_Mutation_p.Q687R|SLC24A1_uc010uji.1_Missense_Mutation_p.Q32R	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	705	Cytoplasmic (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						GCCCAACCCCAGGCCAAAGCA	0.547													2	6					0	0	0	0	G	65936825	G	G	65936825	3	3	279	1	0	0	0	0	1	0	0	0	14529	188	7	5	234	5	SLC24A1	15	65936825	Missense_Mutation	SNP	A	TCGA-D6-6824-01A-11D-1912-08	16160263	65936825	36594567	54	52272											
LASS3	204219	broad.mit.edu	37	chr15	101016321	101016321	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acatcaaagccaagtctaaaTaacagagaccaataaaaact	22	6	4	9	0	2	1	1	0	1	1	2	2	2	1	2	0	3	0	2	0	9	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:101016321T>A	uc002bvz.2	-	9	1081	c.579A>T	c.(577-579)TTA>TTT	p.L193F	LASS3_uc002bwa.2_Missense_Mutation_p.L204F|LASS3_uc002bwb.2_Missense_Mutation_p.L193F	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	193	Helical; (Potential).|TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			CAAGTCTAAATAACAGAGACC	0.363													7	97					0	0	0	0	A	101016321	A	A	101016321	3	1	279	1	0	0	0	0	1	0	0	0	8680	1403	49	5	592	5	LASS3	15	101016321	Missense_Mutation	SNP	T	TCGA-D6-6824-01A-11D-1912-08	35079496	101016321	1515071	55	52273											
GPR139	124274	broad.mit.edu	37	chr16	20043921	20043921	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcggcagcagcgagtgccaaGagatagttgtaggaggactt	11	8	15	7	2	0	1	0	0	0	1	1	5	0	3	1	3	3	4	1	3	3	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr16:20043921G>C	uc002dgu.1	-	2	360	c.198C>G	c.(196-198)CTC>CTG	p.L66L	GPR139_uc010vaw.1_5'UTR	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	66	Helical; Name=2; (Potential).					integral to membrane|plasma membrane				ovary(2)	2						CGAGTGCCAAGAGATAGTTGT	0.468													3	44					0	0	0	0	C	20043921	C	C	20043921	2	2	279	1	0	0	0	0	0	0	0	1	6686	929	33	2		2	GPR139	16	20043921	Silent	SNP	G	TCGA-D6-6824-01A-11D-1912-08		20043921	70310832	56	52274											
MT1A	4489	broad.mit.edu	37	chr16	56670369	56670369	+	5'Flank	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggtggctcctgcacgtgcgCcggctcctgcaagtgcaaag	7	7	14	13	3	0	0	0	0	0	0	2	0	2	0	3	3	4	5	3	3	2	0			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr16:56670369C>T	uc002ejq.2	+						MT1A_uc002eji.2_Intron|uc002ejo.1_RNA|uc002ejp.1_RNA	NM_005946	NP_005937	P04731	MT1A_HUMAN	metallothionein 1A							cytoplasm	cadmium ion binding|copper ion binding|zinc ion binding				0						TGCACGTGCGCCGGCTCCTGC	0.577													6	63					0	0	0	0	T	56670369	T	T	56670369	1	4	279	0	1	0	0	0	0	0	0	0	9950	754	26	4		4	MT1A	16	56670369	5'Flank	SNP	C	TCGA-D6-6824-01A-11D-1912-08	36626448	56670369	33684384	57	52275											
TP53	7157	broad.mit.edu	37	chr17	7578449	7578450	+	Missense_Mutation	DNP	CC	AA	AA																															ctgtgactgcttgtagatggCcatggcgcggacgcgggtgc																										TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:7578449_7578450CC>AA	uc002gim.2	-	5	674_675	c.480_481GG>TT	c.(478-483)ATGGCC>ATTTCC	p.160_161MA>IS	TP53_uc002gig.1_Missense_Mutation_p.160_161MA>IS|TP53_uc002gih.2_Missense_Mutation_p.160_161MA>IS|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.28_29MA>IS|TP53_uc010cng.1_Missense_Mutation_p.28_29MA>IS|TP53_uc002gii.1_Missense_Mutation_p.28_29MA>IS|TP53_uc010cnh.1_Missense_Mutation_p.160_161MA>IS|TP53_uc010cni.1_Missense_Mutation_p.160_161MA>IS|TP53_uc002gij.2_Missense_Mutation_p.160_161MA>IS|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.67_68MA>IS|TP53_uc002gio.2_Missense_Mutation_p.28_29MA>IS|TP53_uc010vug.1_Missense_Mutation_p.121_122MA>IS	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	160_161	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		MA -> IP (in a sporadic cancer; somatic mutation).|MA -> IS (in sporadic cancers; somatic mutation).|MA -> IT (in a sporadic cancer; somatic mutation).|A -> G (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A161T(44)|p.0?(7)|p.M160I(6)|p.M160K(4)|p.M160V(4)|p.M160L(3)|p.M160fs*10(3)|p.A161fs*9(3)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.V157_C176del20(1)|p.A161fs*19(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.M160T(1)|p.R156fs*18(1)|p.A161fs*10(1)|p.R156_A161del(1)|p.A161fs*20(1)|p.V157_M160delVRAM(1)|p.M160_A161>IS(1)|p.A161fs*8(1)|p.S149fs*72(1)|p.A161fs*7(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.A161S(1)|p.A161P(1)|p.V157_I162delVRAMAI(1)|p.A161F(1)|p.A159_Q167delAMAIYKQSQ(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGTAGATGGCCATGGCGCGGA	0.634		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	70					0	0	0	0	AA	7578450	AA	AA	7578449	3	1	279	1	0	0	0	0	1	0	0	0	16448	739	26	4	817	4	TP53	17	7578449	Missense_Mutation	DNP	CC	TCGA-D6-6824-01A-11D-1912-08		7578449	73616761	58	52276											
SLC47A1	55244	broad.mit.edu	37	chr17	19470127	19470127	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcattaatctggtggctcaGgtggttccaatttatgctgt	8	16	10	7	0	3	0	2	0	1	0	4	0	4	0	1	4	1	3	1	4	3	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:19470127G>T	uc002gvy.1	+	13	1217	c.1131G>T	c.(1129-1131)CAG>CAT	p.Q377H	SLC47A1_uc002gvx.2_Missense_Mutation_p.Q377H|SLC47A1_uc010vyz.1_Missense_Mutation_p.Q354H|SLC47A1_uc010cqp.1_Intron|SLC47A1_uc010cqq.1_Missense_Mutation_p.Q182H|SLC47A1_uc010vza.1_Missense_Mutation_p.Q89H|SLC47A1_uc010vzb.1_Missense_Mutation_p.Q111H|SLC47A1_uc010vzc.1_Missense_Mutation_p.Q49H	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	377	Helical; (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					TGGTGGCTCAGGTGGTTCCAA	0.378													5	57					0.00116845	0.00146735	1	0	T	19470127	T	T	19470127	3	4	279	1	0	0	0	0	1	0	0	0	14711	991	35	4	1181	4	SLC47A1	17	19470127	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	11891678	19470127	61725083	59	52277											
SSH2	85464	broad.mit.edu	37	chr17	27958126	27958126	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctctccactggcttgctCtgcacaatacactctgttgt	6	13	8	14	0	3	0	0	0	3	0	4	0	3	0	2	2	3	4	2	2	2	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:27958126C>T	uc002heo.1	-	15	4005	c.4005G>A	c.(4003-4005)CAG>CAA	p.Q1335Q	SSH2_uc010wbh.1_Silent_p.Q1362Q	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	1335					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						CTGGCTTGCTCTGCACAATAC	0.507													4	54					0	0	0	0	T	27958126	T	T	27958126	2	4	279	1	0	0	0	0	0	0	0	1	15251	912	32	2		2	SSH2	17	27958126	Silent	SNP	C	TCGA-D6-6824-01A-11D-1912-08	8487999	27958126	53237084	60	52278											
PLEKHM1	9842	broad.mit.edu	37	chr17	43522926	43522926	+	Missense_Mutation	SNP	T	G	G																															cccgtctcctcccaatgaggTgcatccgctccacatgctcg																										TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:43522926T>G	uc002ija.2	-	9	2917	c.2747A>C	c.(2746-2748)CAC>CCC	p.H916P	PLEKHM1_uc010wjm.1_Missense_Mutation_p.H888P|PLEKHM1_uc002ijb.2_Missense_Mutation_p.H391P|PLEKHM1_uc010wjn.1_Missense_Mutation_p.H865P	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	916					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					CCCAATGAGGTGCATCCGCTC	0.617													6	73					0	0	0	0	G	43522926	G	G	43522926	3	3	279	1	0	0	0	0	1	0	0	0	12135	1696	59	5	439	5	PLEKHM1	17	43522926	Missense_Mutation	SNP	T	TCGA-D6-6824-01A-11D-1912-08	15564800	43522926	37672284	61	52279	118	2									
PLEKHM1	9842	broad.mit.edu	37	chr17	43522928	43522928	+	Missense_Mutation	SNP	C	A	A																															cgtctcctcccaatgaggtgCatccgctccacatgctcgta																										TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:43522928C>A	uc002ija.2	-	9	2915	c.2745G>T	c.(2743-2745)ATG>ATT	p.M915I	PLEKHM1_uc010wjm.1_Missense_Mutation_p.M887I|PLEKHM1_uc002ijb.2_Missense_Mutation_p.M390I|PLEKHM1_uc010wjn.1_Missense_Mutation_p.M864I	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	915					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					CAATGAGGTGCATCCGCTCCA	0.612													6	75					0.00448238	0.00537886	1	0	A	43522928	A	A	43522928	3	1	279	1	0	0	0	0	1	0	0	0	12135	710	25	4	441	4	PLEKHM1	17	43522928	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	2	43522928	37672282	62	52280	118	2									
CASKIN2	57513	broad.mit.edu	37	chr17	73499583	73499583	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtactgtggcagccccagtGcacacagccactccagcagg	9	5	12	15	0	0	0	0	0	0	0	1	0	1	0	4	3	5	4	4	3	1	1			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:73499583G>T	uc002joc.2	-	17	2256	c.1706C>A	c.(1705-1707)GCA>GAA	p.A569E	CASKIN2_uc010wsc.1_Missense_Mutation_p.A487E	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	569	SAM 2.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGCCCCAGTGCACACAGCCA	0.642													4	41					1.024e-07	1.3999e-07	1	0	T	73499583	T	T	73499583	3	4	279	1	0	0	0	0	1	0	0	0	2679	1319	46	4	1918	4	CASKIN2	17	73499583	Missense_Mutation	SNP	G	TCGA-D6-6824-01A-11D-1912-08	29976655	73499583	7695627	63	52281											
ALPK2	115701	broad.mit.edu	37	chr18	56203268	56203268	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttaaagaaggcagtgtgaTccatcttgagttgtttttcc	9	17	9	6	0	1	3	0	2	1	1	3	3	3	3	2	1	0	3	2	1	3	6			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr18:56203268T>C	uc002lhj.3	-	5	4365	c.4151A>G	c.(4150-4152)GAT>GGT	p.D1384G	ALPK2_uc002lhk.1_Missense_Mutation_p.D715G	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1384							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GGCAGTGTGATCCATCTTGAG	0.428													4	118					0	0	0	0	C	56203268	C	C	56203268	3	2	279	1	0	0	0	0	1	0	0	0	545	1435	50	5	2397	5	ALPK2	18	56203268	Missense_Mutation	SNP	T	TCGA-D6-6824-01A-11D-1912-08		56203268	21873980	64	52282											
THEG	51298	broad.mit.edu	37	chr19	371324	371324	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccagacaggagtcgtccTgggggaggtccccattttag	7	8	16	10	1	0	1	0	0	0	1	3	3	2	3	4	5	0	0	4	5	1	2			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:371324T>A	uc002lol.2	-	6	675	c.636_splice	c.e6-1	p.R212_splice	THEG_uc002lom.2_Splice_Site_p.R188_splice	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1						cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGTCGTCCTGGGGGAGGTC	0.463													6	163					0	0	0	0	A	371324	A	A	371324	5	1	279	1	0	0	0	0	0	0	1	0	15923	1594	55	5	517	5	THEG	19	371324	Splice_Site	SNP	T	TCGA-D6-6824-01A-11D-1912-08		371324	58757659	65	52283											
STXBP2	6813	broad.mit.edu	37	chr19	7709561	7709561	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggactccatgaagctgatcgTtccggtgctgctggacgcgg	6	9	15	11	4	0	2	0	2	0	0	3	4	2	4	2	4	3	4	2	4	1	1			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:7709561T>C	uc002mha.3	+	14	1214	c.1169T>C	c.(1168-1170)GTT>GCT	p.V390A	STXBP2_uc002mhb.3_Missense_Mutation_p.V387A|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Missense_Mutation_p.V401A|STXBP2_uc010dvk.2_Missense_Mutation_p.V358A|STXBP2_uc002mhc.3_Missense_Mutation_p.V158A|STXBP2_uc002mhe.1_Missense_Mutation_p.V18A	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	390					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						AAGCTGATCGTTCCGGTGCTG	0.652													4	53					0	0	0	0	C	7709561	C	C	7709561	3	2	279	1	0	0	0	0	1	0	0	0	15419	1725	60	5	1223	5	STXBP2	19	7709561	Missense_Mutation	SNP	T	TCGA-D6-6824-01A-11D-1912-08	7338237	7709561	51419422	66	52284											
LMTK3	114783	broad.mit.edu	37	chr19	49014769	49014769	+	Frame_Shift_Del	DEL	G	-	-																															cagactcaccggggtgggccGgggacgccaggcagccggag																										TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:49014769delG	uc002pjk.2	-	2	152	c.152delC	c.(151-153)CCGfs	p.P51fs		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGGGTGGGCCGGGGACGCCAG	0.741													---	---	---								-	49014769	-	-	49014769	7	5	279	1	0	1	0	1	0	0	0	0	8902	1116	39	0	4377	0	LMTK3	19	49014769	Frame_Shift_Del	DEL	G	TCGA-D6-6824-01A-11D-1912-08	41305208	49014769	10114214	67	52285											
HRC	3270	broad.mit.edu	37	chr19	49657229	49657229	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tcctcatcttcctccctgggGactctgtggtggtgatggtg	3	14	13	11	0	3	1	1	1	2	0	6	2	6	2	3	5	0	0	3	5	0	1			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:49657229G>C	uc002pmv.2	-	1	1453	c.1266C>G	c.(1264-1266)GTC>GTG	p.V422V		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	422					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CCTCCCTGGGGACTCTGTGGT	0.537													3	93					0	0	0	0	C	49657229	C	C	49657229	2	2	279	1	0	0	0	0	0	0	0	1	7391	1161	41	2		2	HRC	19	49657229	Silent	SNP	G	TCGA-D6-6824-01A-11D-1912-08	642460	49657229	9471754	68	52286											
POTEH	23784	broad.mit.edu	37	chr22	16279264	16279264	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttcaccacttgctgttttTgctcatgtacaccaagtaac	10	15	5	11	0	2	0	2	0	0	0	2	0	2	0	2	0	4	5	2	0	3	6			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr22:16279264T>A	uc010gqp.2	-	4	1011	c.959A>T	c.(958-960)CAA>CTA	p.Q320L	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.Q39L|POTEH_uc002zlj.1_Missense_Mutation_p.Q155L	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	320	ANK 5.									skin(1)	1						TTGCTGTTTTTGCTCATGTAC	0.328													6	376					0	0	0	0	A	16279264	A	A	16279264	3	1	279	1	0	0	0	0	1	0	0	0	12322	1812	63	5	706	5	POTEH	22	16279264	Missense_Mutation	SNP	T	TCGA-D6-6824-01A-11D-1912-08		16279264	35025302	69	52287											
HUWE1	10075	broad.mit.edu	37	chrX	53571698	53571698	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcgcttctgagatgccacaaTtaccacattctcagccatgt	10	12	6	13	1	2	1	1	1	2	1	4	2	2	1	3	0	3	1	3	0	2	3			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:53571698T>G	uc004dsp.2	-	72	11476	c.11074A>C	c.(11074-11076)ATT>CTT	p.I3692L	HUWE1_uc004dsn.2_Missense_Mutation_p.I2500L|HUWE1_uc004dsq.1_Missense_Mutation_p.I7L	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3692					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GATGCCACAATTACCACATTC	0.483													4	39					0	0	0	0	G	53571698	G	G	53571698	3	3	279	1	0	0	0	0	1	0	0	0	7500	1493	52	5	2102	5	HUWE1	23	53571698	Missense_Mutation	SNP	T	TCGA-D6-6824-01A-11D-1912-08		53571698	101698862	70	52288											
ZMAT1	84460	broad.mit.edu	37	chrX	101138797	101138797	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcttctgatgtttctgtttAtgacctgcttgatggtcagc	5	18	9	9	0	4	3	1	3	3	0	4	3	4	3	1	1	2	3	1	1	1	5			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:101138797A>G	uc004eim.2	-	2	4587	c.1089T>C	c.(1087-1089)CAT>CAC	p.H363H	ZMAT1_uc011mrl.1_Silent_p.H534H|ZMAT1_uc004ein.2_Silent_p.H363H|ZMAT1_uc011mrm.1_Silent_p.H363H	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	363						nucleus	zinc ion binding			ovary(1)	1						GTTTCTGTTTATGACCTGCTT	0.383													4	51					0	0	0	0	G	101138797	G	G	101138797	2	3	279	1	0	0	0	0	0	0	0	1	17758	446	16	5		5	ZMAT1	23	101138797	Silent	SNP	A	TCGA-D6-6824-01A-11D-1912-08	47567099	101138797	54131763	71	52289											
SERPINA7	6906	broad.mit.edu	37	chrX	105280605	105280605	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcatagagggtcttgacatCattcaagaactttgccagtg	11	12	9	9	0	4	3	3	1	1	2	4	3	4	3	1	1	2	0	1	1	3	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:105280605C>T	uc004eme.1	-	1	461	c.445G>A	c.(445-447)GAT>AAT	p.D149N	SERPINA7_uc010npd.2_Missense_Mutation_p.D149N|SERPINA7_uc010npe.1_Missense_Mutation_p.D149N	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	149					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	GTCTTGACATCATTCAAGAAC	0.428													6	95					0	0	0	0	T	105280605	T	T	105280605	3	4	279	1	0	0	0	0	1	0	0	0	14159	826	29	2	818	2	SERPINA7	23	105280605	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	4141808	105280605	49989955	72	52290											
SLC6A14	11254	broad.mit.edu	37	chrX	115582641	115582641	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgccactcagatattttactCcctttcagtggcttggggtg	6	15	10	10	0	2	1	2	0	0	1	3	1	3	1	2	3	2	1	2	3	2	5			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:115582641C>T	uc004eqi.2	+	8	1069	c.965C>T	c.(964-966)TCC>TTC	p.S322F		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	322	Helical; Name=6; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	ATATTTTACTCCCTTTCAGTG	0.303													5	46					0	0	0	0	T	115582641	T	T	115582641	3	4	279	1	0	0	0	0	1	0	0	0	14741	855	30	2	995	2	SLC6A14	23	115582641	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	10302036	115582641	39687919	73	52291											
MAGEC1	9947	broad.mit.edu	37	chrX	140994645	140994645	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagattcctgtgagctcctcCtcctcctcctccactttatt	5	15	4	17	0	0	2	0	1	0	1	7	2	7	2	7	0	1	1	7	0	1	4			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:140994645C>T	uc004fbt.2	+	4	1741	c.1455C>T	c.(1453-1455)TCC>TCT	p.S485S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	485							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGCTCCTCCTCCTCCTCCT	0.478										HNSCC(15;0.026)			7	126					0	0	0	0	T	140994645	T	T	140994645	2	4	279	1	0	0	0	0	0	0	0	1	9233	668	24	4		4	MAGEC1	23	140994645	Silent	SNP	C	TCGA-D6-6824-01A-11D-1912-08	25412004	140994645	14275915	74	52292											
MAGEA6	4105	broad.mit.edu	37	chrX	151870027	151870027	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gggagggaagacagtatcttCggggatcccaagaagctgct	11	7	15	8	1	1	2	0	0	1	2	3	5	2	5	1	4	2	3	1	4	4	2	rs144083108		TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:151870027C>G	uc004ffq.1	+	3	911	c.717C>G	c.(715-717)TTC>TTG	p.F239L	MAGEA6_uc004ffr.1_Missense_Mutation_p.F239L|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	239	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGTATCTTCGGGGATCCCA	0.537													10	124					0	0	0	0	G	151870027	G	G	151870027	3	3	279	1	0	0	0	0	1	0	0	0	9221	883	31	3	719	3	MAGEA6	23	151870027	Missense_Mutation	SNP	C	TCGA-D6-6824-01A-11D-1912-08	10875382	151870027	3400533	75	52293											
PANK4	55229	broad.mit.edu	37	chr1	2451776	2451776	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cataccttcgttttggtgagCagagcgccaagcccccagaa	10	8	10	13	2	0	3	0	1	0	2	1	3	0	3	4	1	4	2	4	1	3	4			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr1:2451776C>A	uc001ajm.1	-	5	693	c.684G>T	c.(682-684)CTG>CTT	p.L228L	PANK4_uc010nza.1_Silent_p.L189L	NM_018216	NP_060686	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	228					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		TTTTGGTGAGCAGAGCGCCAA	0.647													13	50					3.27435e-08	6.1928e-08	1	0	A	2451776	A	A	2451776	2	1	280	1	0	0	0	0	0	0	0	1	11473	697	25	4		4	PANK4	1	2451776	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08		2451776	246798845	1	52294											
UBE4B	10277	broad.mit.edu	37	chr1	10209286	10209286	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtccccaaggtatttgcagCgttgcctgagttttatgtag	7	15	11	8	1	0	1	0	1	0	0	1	1	1	1	3	1	3	5	3	1	4	6			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr1:10209286C>T	uc001aqs.3	+	20	3349	c.2636C>T	c.(2635-2637)GCG>GTG	p.A879V	UBE4B_uc001aqr.3_Missense_Mutation_p.A750V|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Missense_Mutation_p.A334V|UBE4B_uc001aqt.1_Missense_Mutation_p.A219V	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	879					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GTATTTGCAGCGTTGCCTGAG	0.289													13	100					0	0	0	0	T	10209286	T	T	10209286	3	4	280	1	0	0	0	0	1	0	0	0	16951	768	27	1	2714	1	UBE4B	1	10209286	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	7757510	10209286	239041335	2	52295											
SLC9A11	284525	broad.mit.edu	37	chr1	173493986	173493986	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggaaggtgagattttttaGagctttagcaatcacattcc	13	13	9	6	0	1	2	1	1	0	2	2	4	2	3	1	2	2	2	1	2	5	6			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr1:173493986G>T	uc001giz.2	-	20	2869	c.2446C>A	c.(2446-2448)CTA>ATA	p.L816I	SLC9A11_uc009wwe.2_Missense_Mutation_p.L374I|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	816					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						AGATTTTTTAGAGCTTTAGCA	0.373													13	50					2.27111e-07	4.24917e-07	1	0	T	173493986	T	T	173493986	3	4	280	1	0	0	0	0	1	0	0	0	14775	933	33	2	964	2	SLC9A11	1	173493986	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	163284700	173493986	75756635	3	52296											
C1orf125	126859	broad.mit.edu	37	chr1	179437611	179437611	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttccaagtttgattagttCtcttgacttctgttctttca	6	21	5	9	0	5	2	1	2	4	0	7	2	6	2	1	0	0	3	1	0	2	8			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr1:179437611C>G	uc001gmo.2	+	17	1959	c.1832C>G	c.(1831-1833)TCT>TGT	p.S611C	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_3'UTR|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.S611C	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	611											0						TTGATTAGTTCTCTTGACTTC	0.299													11	39					0	0	0	0	G	179437611	G	G	179437611	3	3	280	1	0	0	0	0	1	0	0	0	2002	913	32	2	1894	2	C1orf125	1	179437611	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	5943625	179437611	69813010	4	52297											
OR2T1	26696	broad.mit.edu	37	chr1	248569358	248569361	+	Frame_Shift_Del	DEL	AATT	-	-																															ttaaaagtttgctgcctaacAattaattcacatgttgttat																								rs149888596	by1000genomes	TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr1:248569358_248569361delAATT	uc010pzm.1	+	1	63_66	c.63_66delAATT	c.(61-66)ACAATTfs	p.T21fs		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	21_22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTGCCTAACAATTAATTCACATG	0.338													---	---	---								-	248569361	-	-	248569358	7	5	280	1	0	1	0	1	0	0	0	0	11070	117	5	0	65	0	OR2T1	1	248569358	Frame_Shift_Del	DEL	AATT	TCGA-D6-6825-01A-21D-1912-08	69131747	248569358	681263	5	52298											
MAPRE3	22924	broad.mit.edu	37	chr2	27248513	27248513	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctggccggctgagcaatGtggcccccccctgcattctc	4	9	10	18	1	2	1	0	1	2	0	3	1	2	1	6	3	2	3	6	3	1	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr2:27248513G>A	uc002rhw.2	+	5	685	c.532G>A	c.(532-534)GTG>ATG	p.V178M	MAPRE3_uc002rhx.2_Missense_Mutation_p.V163M	NM_012326	NP_036458	Q9UPY8	MARE3_HUMAN	microtubule-associated protein, RP/EB family,	178					cell division|mitosis|positive regulation of transcription, DNA-dependent	cytoplasm|cytoplasmic microtubule|microtubule|midbody|perinuclear region of cytoplasm	microtubule binding|protein binding|small GTPase regulator activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGAGCAATGTGGCCCCCCC	0.567													12	47					0	0	0	0	A	27248513	A	A	27248513	3	1	280	1	0	0	0	0	1	0	0	0	9349	1377	48	4	546	4	MAPRE3	2	27248513	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08		27248513	215950860	6	52299											
HSPC159	29094	broad.mit.edu	37	chr2	64683576	64683576	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagcaatcccttactttccaTtcattccagaccagccattc	10	12	3	16	0	1	1	1	0	0	1	5	1	4	1	5	0	3	1	5	0	2	5			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr2:64683576T>C	uc002scy.3	+	4	705	c.352T>C	c.(352-354)TTC>CTC	p.F118L		NM_014181	NP_054900	Q3ZCW2	LEGL_HUMAN	galectin-related protein	118	Galectin.					intracellular	sugar binding				0						TTACTTTCCATTCATTCCAGA	0.493													31	168					0	0	0	0	C	64683576	C	C	64683576	3	2	280	1	0	0	0	0	1	0	0	0	7466	1493	52	5	366	5	HSPC159	2	64683576	Missense_Mutation	SNP	T	TCGA-D6-6825-01A-21D-1912-08	37435063	64683576	178515797	7	52300											
HTRA2	27429	broad.mit.edu	37	chr2	74757782	74757782	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgaggtccctatctcgaacgGctcaggattcgtggtggctg	6	10	14	11	4	2	0	1	0	1	0	5	3	3	1	1	5	1	2	1	5	2	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr2:74757782G>T	uc002smi.1	+	2	1147	c.545G>T	c.(544-546)GGC>GTC	p.G182V	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Missense_Mutation_p.G182V|HTRA2_uc002smk.1_Missense_Mutation_p.G182V|HTRA2_uc002sml.1_Missense_Mutation_p.G182V|HTRA2_uc002smm.1_5'UTR|HTRA2_uc002smn.1_5'UTR|HTRA2_uc010ffl.2_5'UTR	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	182	Serine protease.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						ATCTCGAACGGCTCAGGATTC	0.622													11	53					2.80697e-09	5.36718e-09	1	0	T	74757782	T	T	74757782	3	4	280	1	0	0	0	0	1	0	0	0	7493	1203	42	4	551	4	HTRA2	2	74757782	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	10074206	74757782	168441591	8	52301											
C2orf89	129293	broad.mit.edu	37	chr2	85051144	85051144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctccgctgtgaccgcctccGcttcttccggaacctctgtt	3	12	8	18	4	2	1	0	1	2	0	5	2	5	2	7	1	1	3	7	1	1	3			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr2:85051144G>A	uc010ysl.1	-	6	1356	c.1267C>T	c.(1267-1269)CGG>TGG	p.R423W	C2orf89_uc002sou.3_Missense_Mutation_p.R374W	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	423	Extracellular (Potential).					integral to membrane				ovary(1)	1						GACCGCCTCCGCTTCTTCCGG	0.657													7	21					0	0	0	0	A	85051144	A	A	85051144	3	1	280	1	0	0	0	0	1	0	0	0	2213	1086	38	1	258	1	C2orf89	2	85051144	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	10293362	85051144	158148229	9	52302											
LRP1B	53353	broad.mit.edu	37	chr2	141457979	141457979	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taacgtggattctcatatggCcttattggggaatttaaatt	11	16	9	5	1	1	0	1	0	1	0	2	2	1	2	1	4	1	0	1	4	6	8	rs143179717	byFrequency	TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr2:141457979C>T	uc002tvj.1	-	41	7611	c.6639G>A	c.(6637-6639)AGG>AGA	p.R2213R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2213	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTCATATGGCCTTATTGGGG	0.348										TSP Lung(27;0.18)			22	79					0	0	0	0	T	141457979	T	T	141457979	2	4	280	1	0	0	0	0	0	0	0	1	9005	738	26	4		4	LRP1B	2	141457979	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08	56406835	141457979	101741394	10	52303											
COBLL1	22837	broad.mit.edu	37	chr2	165551294	165551294	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgatactctcttctgcatctGcaaaaaaaaagagctgggtt	13	11	8	9	1	3	1	0	0	3	1	4	2	3	1	0	1	4	4	0	1	5	3			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr2:165551294G>A	uc010zcw.1	-	15	3047	c.2923C>T	c.(2923-2925)CAG>TAG	p.Q975*	COBLL1_uc002ucp.2_Nonsense_Mutation_p.Q908*|COBLL1_uc002ucq.2_Nonsense_Mutation_p.Q870*|COBLL1_uc010zcx.1_Nonsense_Mutation_p.Q916*|COBLL1_uc002ucn.2_Nonsense_Mutation_p.Q336*|COBLL1_uc002uco.2_Nonsense_Mutation_p.Q639*	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	946										ovary(2)|pancreas(1)	3						TTCTGCATCTGCAAAAAAAAA	0.413													14	43					0	0	0	0	A	165551294	A	A	165551294	4	1	280	1	0	0	0	0	0	1	0	0	3669	1328	46	4	790	4	COBLL1	2	165551294	Nonsense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	24093315	165551294	77648079	11	52304											
LRP2	4036	broad.mit.edu	37	chr2	170025080	170025080	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcttcatctgaaccatcGccacagtcatcatcgccatc	10	11	5	15	2	5	1	3	1	2	0	8	1	5	1	3	0	1	1	3	0	1	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr2:170025080G>A	uc002ues.2	-	61	11817	c.11604C>T	c.(11602-11604)GGC>GGT	p.G3868G		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3868	LDL-receptor class A 34.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTGAACCATCGCCACAGTCAT	0.453													6	32					0	0	0	0	A	170025080	A	A	170025080	2	1	280	1	0	0	0	0	0	0	0	1	9006	1074	38	1		1	LRP2	2	170025080	Silent	SNP	G	TCGA-D6-6825-01A-21D-1912-08	4473786	170025080	73174293	12	52305											
FAM119A	151194	broad.mit.edu	37	chr2	208486636	208486636	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccaggtatgtggaaagaacGatggcctgaatgaaaacaca	16	7	11	7	1	0	3	0	2	0	1	1	5	1	4	2	3	2	1	2	3	6	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr2:208486636G>A	uc002vcf.2	-	3	313	c.153C>T	c.(151-153)ATC>ATT	p.I51I	FAM119A_uc002vce.2_Silent_p.I51I|FAM119A_uc010fuk.1_Silent_p.I51I|FAM119A_uc002vcg.3_Silent_p.I51I	NM_145280	NP_660323	Q8WXB1	MT21A_HUMAN	hypothetical protein LOC151194	51	Helical; (Potential).					integral to membrane	methyltransferase activity				0				LUSC - Lung squamous cell carcinoma(261;0.0705)|Epithelial(149;0.131)|Lung(261;0.135)		TGGAAAGAACGATGGCCTGAA	0.582													13	58					0	0	0	0	A	208486636	A	A	208486636	2	1	280	1	0	0	0	0	0	0	0	1	5441	1048	37	1		1	FAM119A	2	208486636	Silent	SNP	G	TCGA-D6-6825-01A-21D-1912-08	38461556	208486636	34712737	13	52306											
CHCHD4	131474	broad.mit.edu	37	chr3	14154580	14154580	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaccccttgatctcctccGtgctatagtggaagcaggaa	9	10	10	12	1	1	2	0	2	1	0	3	4	2	4	4	2	2	2	4	2	4	3			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr3:14154580G>A	uc003byj.3	-	3	431	c.236C>T	c.(235-237)ACG>ATG	p.T79M	CHCHD4_uc003byi.3_Missense_Mutation_p.T92M	NM_001098502	NP_001091972	Q8N4Q1	MIA40_HUMAN	coiled-coil-helix-coiled-coil-helix domain	79	CHCH.				protein transport|transmembrane transport	mitochondrial intermembrane space					0						GATCTCCTCCGTGCTATAGTG	0.483													11	29					0	0	0	0	A	14154580	A	A	14154580	3	1	280	1	0	0	0	0	1	0	0	0	3333	1145	40	1	196	1	CHCHD4	3	14154580	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08		14154580	183867850	14	52307											
RBMS3	27303	broad.mit.edu	37	chr3	30032698	30032698	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcatattcttaccaacagtcTaagtaagtctgggctgtgct	10	13	9	9	0	3	0	0	0	3	0	3	0	3	0	1	1	3	4	1	1	5	5			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr3:30032698T>C	uc003cel.2	+	14	1535	c.1305T>C	c.(1303-1305)TCT>TCC	p.S435S	RBMS3_uc003cek.2_Silent_p.S419S|RBMS3_uc010hfq.2_Silent_p.S432S|RBMS3_uc003cem.2_Silent_p.S417S|RBMS3_uc010hfr.2_Silent_p.S419S	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	435						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				ACCAACAGTCTAAGTAAGTCT	0.403													15	51					0	0	0	0	C	30032698	C	C	30032698	2	2	280	1	0	0	0	0	0	0	0	1	13215	1509	53	5		5	RBMS3	3	30032698	Silent	SNP	T	TCGA-D6-6825-01A-21D-1912-08	15878118	30032698	167989732	15	52308											
C3orf38	285237	broad.mit.edu	37	chr3	88202409	88202409	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcaatattagcatacagtCaaagtgcagaagaacttctg	16	10	8	7	0	2	2	1	0	1	2	2	2	2	2	0	0	5	3	0	0	7	4			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr3:88202409C>T	uc003dqw.2	+	3	474	c.163C>T	c.(163-165)CAA>TAA	p.Q55*		NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	55					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		AGCATACAGTCAAAGTGCAGA	0.383													8	32					0	0	0	0	T	88202409	T	T	88202409	4	4	280	1	0	0	0	0	0	1	0	0	2238	827	29	2	169	2	C3orf38	3	88202409	Nonsense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	58169711	88202409	109820021	16	52309											
COL6A6	131873	broad.mit.edu	37	chr3	130289967	130289967	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accacatgttcactgaagccCggggcagccgcctgaacaag	11	5	11	14	2	1	2	1	2	0	0	1	2	1	2	4	2	3	2	4	2	3	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr3:130289967C>T	uc010htl.2	+	6	2738	c.2707C>T	c.(2707-2709)CGG>TGG	p.R903W		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	903	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CACTGAAGCCCGGGGCAGCCG	0.542													4	30					0	0	0	0	T	130289967	T	T	130289967	3	4	280	1	0	0	0	0	1	0	0	0	3718	643	23	1	2729	1	COL6A6	3	130289967	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	42087558	130289967	67732463	17	52310											
SPSB4	92369	broad.mit.edu	37	chr3	140785630	140785630	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcaccatgcgctacatcaaCggccttgaccgtaagttgtg	9	10	10	12	3	2	1	2	1	0	0	2	1	2	1	3	1	3	3	3	1	3	4			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr3:140785630C>T	uc003ett.2	+	2	938	c.684C>T	c.(682-684)AAC>AAT	p.N228N	SPSB4_uc010hum.2_Silent_p.N228N	NM_080862	NP_543138	Q96A44	SPSB4_HUMAN	splA/ryanodine receptor domain and SOCS box	228	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding				0						GCTACATCAACGGCCTTGACC	0.632													11	36					0	0	0	0	T	140785630	T	T	140785630	2	4	280	1	0	0	0	0	0	0	0	1	15181	535	19	1		1	SPSB4	3	140785630	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08	10495663	140785630	57236800	18	52311											
NLGN1	22871	broad.mit.edu	37	chr3	173998386	173998386	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accaactttatctccatattGgattaaaaccaagagttaaa	17	12	4	8	0	1	1	0	0	1	1	2	2	1	2	3	1	2	1	3	1	8	6			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr3:173998386G>T	uc003fio.1	+	7	2188	c.1765G>T	c.(1765-1767)GGA>TGA	p.G589*	NLGN1_uc003fip.1_Nonsense_Mutation_p.G589*	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	606	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TCTCCATATTGGATTAAAACC	0.393													8	71					3.09899e-07	5.73642e-07	1	0	T	173998386	T	T	173998386	4	4	280	1	0	0	0	0	0	1	0	0	10515	1349	47	4	1783	4	NLGN1	3	173998386	Nonsense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	33212756	173998386	24024044	19	52312											
GRXCR1	389207	broad.mit.edu	37	chr4	43022418	43022418	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatcaggagaactgcaagaCatcctaaccaaaattgaggt	17	7	9	8	0	1	3	1	1	0	2	2	5	2	3	2	2	3	1	2	2	6	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr4:43022418C>G	uc003gwt.2	+	3	675	c.675C>G	c.(673-675)GAC>GAG	p.D225E		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	225	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						AACTGCAAGACATCCTAACCA	0.308													8	32					0	0	0	0	G	43022418	G	G	43022418	3	3	280	1	0	0	0	0	1	0	0	0	6851	477	17	4	685	4	GRXCR1	4	43022418	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08		43022418	148131858	20	52313											
LNX1	84708	broad.mit.edu	37	chr4	54362403	54362403	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgttgagaatcacatgaaaGctgtcatctcggggtctgta	10	13	11	7	1	4	2	2	2	2	1	5	3	4	2	0	2	1	3	0	2	3	3			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr4:54362403G>A	uc003hag.3	-	6	1393	c.1137C>T	c.(1135-1137)AGC>AGT	p.S379S	PDGFRA_uc003haa.2_Intron|LNX1_uc003haf.3_Silent_p.S283S|LNX1_uc003hah.3_Intron	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a	379						cytoplasm	zinc ion binding	p.A379A(1)		ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TCACATGAAAGCTGTCATCTC	0.542													25	95					0	0	0	0	A	54362403	A	A	54362403	2	1	280	1	0	0	0	0	0	0	0	1	8907	962	34	4		4	LNX1	4	54362403	Silent	SNP	G	TCGA-D6-6825-01A-21D-1912-08	11339985	54362403	136791873	21	52314											
AMBN	258	broad.mit.edu	37	chr4	71472228	71472228	+	Frame_Shift_Del	DEL	C	-	-																															tcagggaagatgaagggactCcccagcgtcaccccagcagc																										TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr4:71472228delC	uc003hfl.2	+	13	1200	c.1125delC	c.(1123-1125)CTCfs	p.L375fs		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	375					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			TGAAGGGACTCCCCAGCGTCA	0.562													---	---	---								-	71472228	-	-	71472228	7	5	280	1	0	1	0	1	0	0	0	0	563	842	30	0	1175	0	AMBN	4	71472228	Frame_Shift_Del	DEL	C	TCGA-D6-6825-01A-21D-1912-08	17109825	71472228	119682048	22	52315											
SEC24B	10427	broad.mit.edu	37	chr4	110452620	110452620	+	Frame_Shift_Del	DEL	T	-	-																															gataaagtctcagccacttgTtcatctaatgaaaatgattc																										TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr4:110452620delT	uc003hzk.2	+	20	3387	c.3332delT	c.(3331-3333)GTTfs	p.V1111fs	SEC24B_uc003hzl.2_Frame_Shift_Del_p.V1076fs|SEC24B_uc011cfp.1_Frame_Shift_Del_p.V1141fs|SEC24B_uc011cfq.1_Frame_Shift_Del_p.V1110fs|SEC24B_uc011cfr.1_Frame_Shift_Del_p.V1075fs	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	1111					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CAGCCACTTGTTCATCTAATG	0.353													---	---	---								-	110452620	-	-	110452620	7	5	280	1	0	1	0	1	0	0	0	0	14060	1725	60	0	3410	0	SEC24B	4	110452620	Frame_Shift_Del	DEL	T	TCGA-D6-6825-01A-21D-1912-08	38980392	110452620	80701656	23	52316											
ADAM29	11086	broad.mit.edu	37	chr4	175898390	175898390	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgagtgatcatactactgtgCattgggctcgcttcaatgac	9	13	10	9	1	2	3	2	3	0	0	3	3	2	3	0	1	3	3	0	1	3	4	rs146793989		TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr4:175898390C>A	uc003iuc.2	+	5	2384	c.1714C>A	c.(1714-1716)CAT>AAT	p.H572N	ADAM29_uc003iud.2_Missense_Mutation_p.H572N|ADAM29_uc010irr.2_Missense_Mutation_p.H572N|ADAM29_uc011cki.1_Missense_Mutation_p.H572N	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	572	Cys-rich.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TACTACTGTGCATTGGGCTCG	0.408													22	104					1.50039e-11	3.00078e-11	1	0	A	175898390	A	A	175898390	3	1	280	1	0	0	0	0	1	0	0	0	247	710	25	4	1716	4	ADAM29	4	175898390	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	65445770	175898390	15255886	24	52317											
SEMA6A	57556	broad.mit.edu	37	chr5	115831982	115831982	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cattctgcatgtgtctacatCggcctgtctagatttccatg	7	15	8	11	1	3	1	0	0	3	1	5	1	4	1	2	1	2	1	2	1	2	4			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr5:115831982C>T	uc010jck.2	-	5	1016	c.307G>A	c.(307-309)GAT>AAT	p.D103N	SEMA6A_uc003krx.3_Missense_Mutation_p.D103N	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	103	Sema.|Extracellular (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		GTGTCTACatcggcctgtcta	0.308													16	88					0	0	0	0	T	115831982	T	T	115831982	3	4	280	1	0	0	0	0	1	0	0	0	14104	884	31	1	2845	1	SEMA6A	5	115831982	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08		115831982	65083278	25	52318											
PCDHB13	56123	broad.mit.edu	37	chr5	140595589	140595589	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccgccaggctgctgagcGagcgcgacgcggccaagcac	8	2	15	16	6	0	1	0	1	0	0	0	3	0	1	3	2	4	4	3	2	1	0			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr5:140595589G>T	uc003lja.1	+	1	2081	c.1894G>T	c.(1894-1896)GAG>TAG	p.E632*		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	632	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGCTGAGCGAGCGCGACGC	0.697													13	57					3.52763e-06	6.32792e-06	1	0	T	140595589	T	T	140595589	4	4	280	1	0	0	0	0	0	1	0	0	11592	1059	37	3	1896	3	PCDHB13	5	140595589	Nonsense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	24763607	140595589	40319671	26	52319											
C5orf4	10826	broad.mit.edu	37	chr5	154214197	154214197	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacctcacctataaagaagaGgatccactccttcccttcaa	14	9	4	14	0	2	2	2	0	0	2	5	3	5	3	5	1	1	0	5	1	6	4			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr5:154214197G>A	uc003lvs.3	-	4	403	c.232C>T	c.(232-234)CTC>TTC	p.L78F	C5orf4_uc011dde.1_Missense_Mutation_p.L55F	NM_032385	NP_115761	Q96IV6	CE004_HUMAN	hypothetical protein LOC10826	78	Helical; (Potential).				fatty acid biosynthetic process	integral to membrane	iron ion binding|oxidoreductase activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATAAAGAAGAGGATCCACTCC	0.453													11	32					0	0	0	0	A	154214197	A	A	154214197	3	1	280	1	0	0	0	0	1	0	0	0	2308	1000	35	4	793	4	C5orf4	5	154214197	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	13618608	154214197	26701063	27	52320											
FAM71B	153745	broad.mit.edu	37	chr5	156592924	156592924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttgggccagaaccatgaCgtcaggcagtgggaggatgg	9	7	18	7	1	1	2	1	1	0	1	1	4	1	4	2	6	1	2	2	6	1	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr5:156592924C>T	uc003lwn.2	-	1	356	c.256G>A	c.(256-258)GTC>ATC	p.V86I		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	86						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGAACCATGACGTCAGGCAGT	0.542													19	76					0	0	0	0	T	156592924	T	T	156592924	3	4	280	1	0	0	0	0	1	0	0	0	5640	536	19	1	1569	1	FAM71B	5	156592924	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	2378727	156592924	24322336	28	52321											
CLIC1	1192	broad.mit.edu	37	chr6	31698702	31698702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagcgaattcttcccgggCgtaggcattgctcaagtacc	9	9	12	11	3	2	0	1	0	1	0	3	2	3	1	2	3	3	4	2	3	5	5			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr6:31698702C>T	uc003nwr.2	-	6	907	c.643G>A	c.(643-645)GCC>ACC	p.A215T	DDAH2_uc003nwp.2_5'Flank|DDAH2_uc003nwq.2_5'Flank|CLIC1_uc003rje.2_Missense_Mutation_p.A215T	NM_001288	NP_001279	O00299	CLIC1_HUMAN	chloride intracellular channel 1	215	GST C-terminal.				signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						TCTTCCCGGGCGTAGGCATTG	0.582													11	49					0	0	0	0	T	31698702	T	T	31698702	3	4	280	1	0	0	0	0	1	0	0	0	3540	768	27	1	86	1	CLIC1	6	31698702	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08		31698702	139416365	29	52322											
EPHA7	2045	broad.mit.edu	37	chr6	93955064	93955064	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaattgtagccagctgccGtgaaattatctttatatctt	10	15	9	7	1	2	1	0	1	2	0	2	2	2	2	2	1	3	2	2	1	6	7	rs151105732	byFrequency	TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr6:93955064G>A	uc003poe.2	-	16	3075	c.2834C>T	c.(2833-2835)ACG>ATG	p.T945M	EPHA7_uc003pof.2_Missense_Mutation_p.T940M|EPHA7_uc011eac.1_Missense_Mutation_p.T941M	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	945	Cytoplasmic (Potential).|SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GCCAGCTGCCGTGAAATTATC	0.363													14	58					0	0	0	0	A	93955064	A	A	93955064	3	1	280	1	0	0	0	0	1	0	0	0	5196	1145	40	1	170	1	EPHA7	6	93955064	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	62256362	93955064	77160003	30	52323											
C6orf167	253714	broad.mit.edu	37	chr6	97677102	97677102	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccatgtgacccttccaaatGagggctctctgagacgttac	9	10	10	12	1	1	3	0	3	1	1	3	4	2	3	3	1	1	2	3	1	2	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr6:97677102G>C	uc003ppb.2	-	14	1973	c.1707C>G	c.(1705-1707)CTC>CTG	p.L569L	C6orf167_uc011eaf.1_Silent_p.L529L	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	569					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		CCTTCCAAATGAGGGCTCTCT	0.448													14	46					0	0	0	0	C	97677102	C	C	97677102	2	2	280	1	0	0	0	0	0	0	0	1	2352	1277	45	2		2	C6orf167	6	97677102	Silent	SNP	G	TCGA-D6-6825-01A-21D-1912-08	3722038	97677102	73437965	31	52324											
ENPP1	5167	broad.mit.edu	37	chr6	132204896	132204896	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttactacaaatatagtgccaAtgtaccagagttttcaaggt	14	13	7	7	0	1	1	1	0	0	1	1	1	1	1	2	1	4	2	2	1	8	7			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr6:132204896A>T	uc011ecf.1	+	22	2313	c.2293A>T	c.(2293-2295)ATG>TTG	p.M765L		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	765	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TATAGTGCCAATGTACCAGAG	0.279													13	70					0	0	0	0	T	132204896	T	T	132204896	3	4	280	1	0	0	0	0	1	0	0	0	5153	101	4	5	2379	5	ENPP1	6	132204896	Missense_Mutation	SNP	A	TCGA-D6-6825-01A-21D-1912-08	34527794	132204896	38910171	32	52325											
SASH1	23328	broad.mit.edu	37	chr6	148840732	148840732	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggtcctggatgaacggtcCgccctctactctggcgtgca	5	9	12	15	4	2	1	0	1	2	0	4	2	4	2	4	4	3	1	4	4	2	1	rs111245321		TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr6:148840732C>T	uc003qme.1	+	10	1387	c.912C>T	c.(910-912)TCC>TCT	p.S304S	SASH1_uc011eeb.1_Silent_p.S65S	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	304							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		ATGAACGGTCCGCCCTCTACT	0.537													10	40					0	0	0	0	T	148840732	T	T	148840732	2	4	280	1	0	0	0	0	0	0	0	1	13913	639	23	1		1	SASH1	6	148840732	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08	16635836	148840732	22274335	33	52326											
SYNE1	23345	broad.mit.edu	37	chr6	152698022	152698022	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatcctctgttctaggctctGctttttgcaaagcatccagt	7	15	8	11	0	3	0	0	0	3	0	5	1	5	0	2	1	3	5	2	1	2	4			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr6:152698022G>C	uc010kiw.2	-	57	9637	c.9035C>G	c.(9034-9036)GCA>GGA	p.A3012G	SYNE1_uc003qot.3_Missense_Mutation_p.A3019G|SYNE1_uc003qou.3_Missense_Mutation_p.A3012G|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_Missense_Mutation_p.A90G|SYNE1_uc010kjb.1_Missense_Mutation_p.A2995G	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3012	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCTAGGCTCTGCTTTTTGCAA	0.408										HNSCC(10;0.0054)			7	30					0	0	0	0	C	152698022	C	C	152698022	3	2	280	1	0	0	0	0	1	0	0	0	15511	1319	46	4	17791	4	SYNE1	6	152698022	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	3857290	152698022	18417045	34	52327											
GLCCI1	113263	broad.mit.edu	37	chr7	8095132	8095132	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcacagtaaggagaaagatCgccagtcacctcttcatggc	12	8	10	11	1	4	2	3	0	1	2	5	3	4	2	2	2	0	1	2	2	2	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr7:8095132C>T	uc003srk.2	+	4	1325	c.766C>T	c.(766-768)CGC>TGC	p.R256C		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	256											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		GGAGAAAGATCGCCAGTCACC	0.423													6	52					0	0	0	0	T	8095132	T	T	8095132	3	4	280	1	0	0	0	0	1	0	0	0	6468	884	31	1	780	1	GLCCI1	7	8095132	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08		8095132	151043531	35	52328											
VPS41	27072	broad.mit.edu	37	chr7	38835131	38835131	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagcagaggctgcagggataCatgtctgggcgaagacttat	11	8	14	8	1	1	2	0	0	1	2	1	4	1	3	0	3	3	3	0	3	3	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr7:38835131C>A	uc003tgy.2	-	9	677	c.651G>T	c.(649-651)ATG>ATT	p.M217I	VPS41_uc003tgz.2_Missense_Mutation_p.M192I|VPS41_uc010kxn.2_Intron	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	217					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TGCAGGGATACATGTCTGGGC	0.443													9	50					2.17888e-05	3.86862e-05	1	0	A	38835131	A	A	38835131	3	1	280	1	0	0	0	0	1	0	0	0	17278	478	17	4	1997	4	VPS41	7	38835131	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	30739999	38835131	120303532	36	52329											
ZNF680	340252	broad.mit.edu	37	chr7	63982197	63982197	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccagtatgaattctcttaTggttagtaagggttgcaaac	11	14	9	7	0	1	1	0	1	1	0	3	1	2	1	1	2	2	5	1	2	6	6			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr7:63982197T>C	uc003tta.2	-	4	1108	c.935A>G	c.(934-936)CAT>CGT	p.H312R	ZNF680_uc010kzr.2_Missense_Mutation_p.H239R	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	312	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				AATTCTCTTATGGTTAGTAAG	0.333													8	29					0	0	0	0	C	63982197	C	C	63982197	3	2	280	1	0	0	0	0	1	0	0	0	18154	1464	51	5	661	5	ZNF680	7	63982197	Missense_Mutation	SNP	T	TCGA-D6-6825-01A-21D-1912-08	25147066	63982197	95156466	37	52330											
MUC17	140453	broad.mit.edu	37	chr7	100679245	100679245	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtgaaggaagcactgcattAacaagtatacctgtcagcac	15	8	9	9	0	1	1	1	1	0	0	1	2	1	2	1	1	5	4	1	1	6	3			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr7:100679245A>G	uc003uxp.1	+	3	4601	c.4548A>G	c.(4546-4548)TTA>TTG	p.L1516L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1516	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|23.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCACTGCATTAACAAGTATAC	0.483													55	234					0	0	0	0	G	100679245	G	G	100679245	2	3	280	1	0	0	0	0	0	0	0	1	10027	359	13	5		5	MUC17	7	100679245	Silent	SNP	A	TCGA-D6-6825-01A-21D-1912-08	36697048	100679245	58459418	38	52331											
PTPRZ1	5803	broad.mit.edu	37	chr7	121608117	121608117	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtaaatgtgaatcttaagaaActtaaatttcagggttggga	15	13	10	3	0	2	2	1	1	1	1	2	3	2	3	0	2	1	2	0	2	7	5			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr7:121608117A>G	uc003vjy.2	+	3	632	c.237A>G	c.(235-237)AAA>AAG	p.K79K	PTPRZ1_uc003vjz.2_Silent_p.K79K	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	79	Extracellular (Potential).|Alpha-carbonic anhydrase.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ATCTTAAGAAACTTAAATTTC	0.299													17	51					0	0	0	0	G	121608117	G	G	121608117	2	3	280	1	0	0	0	0	0	0	0	1	12879	40	2	5		5	PTPRZ1	7	121608117	Silent	SNP	A	TCGA-D6-6825-01A-21D-1912-08	20928872	121608117	37530546	39	52332											
OR9A4	130075	broad.mit.edu	37	chr7	141619469	141619469	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctacgtgaaacccaagcaaaCgcaggcagctgattacaatt	15	7	8	11	2	0	2	0	2	0	0	0	2	0	2	1	1	6	4	1	1	6	3			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr7:141619469C>T	uc003vwu.1	+	1	794	c.794C>T	c.(793-795)ACG>ATG	p.T265M		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					CCCAAGCAAACGCAGGCAGCT	0.478													12	66					0	0	0	0	T	141619469	T	T	141619469	3	4	280	1	0	0	0	0	1	0	0	0	11303	536	19	1	796	1	OR9A4	7	141619469	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	20011352	141619469	17519194	40	52333											
RARRES2	5919	broad.mit.edu	37	chr7	150037213	150037213	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgggcctgactttgcactcGggtttcttccagtccctctt	3	16	9	13	1	2	1	0	1	2	0	5	1	4	1	3	2	1	2	3	2	0	5			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr7:150037213G>C	uc003wha.2	-	3	372	c.255C>G	c.(253-255)CCC>CCG	p.P85P	RARRES2_uc010lpp.1_Silent_p.P85P	NM_002889	NP_002880	Q99969	RARR2_HUMAN	chemerin preproprotein	85					embryonic digestive tract development|in utero embryonic development|positive regulation of macrophage chemotaxis|retinoid metabolic process	extracellular matrix	receptor binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.011)			CTTTGCACTCGGGTTTCTTCC	0.582													9	566					0	0	0	0	C	150037213	C	C	150037213	2	2	280	1	0	0	0	0	0	0	0	1	13121	1103	39	3		3	RARRES2	7	150037213	Silent	SNP	G	TCGA-D6-6825-01A-21D-1912-08	8417744	150037213	9101450	41	52334											
VIPR2	7434	broad.mit.edu	37	chr7	158824757	158824757	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcgtggacttggccagccTcctgcacagaaggagatgag	10	6	15	10	1	0	3	0	1	0	2	1	6	1	4	3	3	3	1	3	3	1	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr7:158824757T>C	uc003woh.2	-	11	1159	c.973A>G	c.(973-975)AGG>GGG	p.R325G	VIPR2_uc010lqx.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	325	Cytoplasmic (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		TTGGCCAGCCTCCTGCACAGA	0.602													6	35					0	0	0	0	C	158824757	C	C	158824757	3	2	280	1	0	0	0	0	1	0	0	0	17238	1565	54	5	355	5	VIPR2	7	158824757	Missense_Mutation	SNP	T	TCGA-D6-6825-01A-21D-1912-08	8787544	158824757	313906	42	52335											
ZFHX4	79776	broad.mit.edu	37	chr8	77616511	77616511	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caaaagtgaagccttgctggGtttcagcgttgagaatgcag	11	10	13	7	1	1	2	1	2	0	1	1	3	1	2	1	1	4	4	1	1	4	3			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr8:77616511G>T	uc003yav.2	+	2	575	c.188G>T	c.(187-189)GGT>GTT	p.G63V	ZFHX4_uc003yat.1_Missense_Mutation_p.G63V|ZFHX4_uc003yau.1_Missense_Mutation_p.G63V|ZFHX4_uc003yaw.1_Missense_Mutation_p.G63V	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	63						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCTTGCTGGGTTTCAGCGTT	0.498										HNSCC(33;0.089)			21	78					1.40151e-16	2.83561e-16	1	0	T	77616511	T	T	77616511	3	4	280	1	0	0	0	0	1	0	0	0	17702	1261	44	4	190	4	ZFHX4	8	77616511	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08		77616511	68747511	43	52336											
COL14A1	7373	broad.mit.edu	37	chr8	121239492	121239492	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagagcaggactcacatgttAttgaaggcctggagcccggt	11	8	13	9	1	1	2	1	1	0	1	1	4	1	4	2	4	2	2	2	4	3	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr8:121239492A>G	uc003yox.2	+	17	2303	c.2038A>G	c.(2038-2040)ATT>GTT	p.I680V	COL14A1_uc003yoy.2_Missense_Mutation_p.I358V	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	680	Fibronectin type-III 5.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CTCACATGTTATTGAAGGCCT	0.428													11	44					0	0	0	0	G	121239492	G	G	121239492	3	3	280	1	0	0	0	0	1	0	0	0	3686	449	16	5	2100	5	COL14A1	8	121239492	Missense_Mutation	SNP	A	TCGA-D6-6825-01A-21D-1912-08	43622981	121239492	25124530	44	52337											
ATAD2	29028	broad.mit.edu	37	chr8	124340642	124340642	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tttcttccaccgaagactctCctgtgtttccggtctcatta	6	16	6	13	2	3	1	1	0	3	1	7	2	5	1	4	1	0	1	4	1	2	4			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr8:124340642C>T	uc003yqh.3	-	25	3764	c.3656G>A	c.(3655-3657)GGA>GAA	p.G1219E	ATAD2_uc011lii.1_Missense_Mutation_p.G1010E|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1219					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CGAAGACTCTCCTGTGTTTCC	0.373													27	97					0	0	0	0	T	124340642	T	T	124340642	3	4	280	1	0	0	0	0	1	0	0	0	1073	855	30	2	532	2	ATAD2	8	124340642	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	3101150	124340642	22023380	45	52338											
MYC	4609	broad.mit.edu	37	chr8	128750945	128750945	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggccgccgccaagctcgtctCagagaagctggcctcctacc	7	6	11	17	3	1	1	1	0	1	1	4	2	2	1	6	2	3	2	6	2	3	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr8:128750945C>T	uc003ysh.1	+	3	950	c.437C>T	c.(436-438)TCA>TTA	p.S146L	MYC_uc003ysi.2_Missense_Mutation_p.S161L	NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	146					branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		AAGCTCGTCTCAGAGAAGCTG	0.622		3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	26					0	0	0	0	T	128750945	T	T	128750945	3	4	280	1	0	0	0	0	1	0	0	0	10069	838	29	2	488	2	MYC	8	128750945	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	4410303	128750945	17613077	46	52339											
CDKN2A	1029	broad.mit.edu	37	chr9	21971000	21971000	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacatcgcgatggcccagctCctcagccaggtccacgggca	8	5	12	16	3	1	0	1	0	0	0	4	2	3	0	4	3	2	2	4	3	0	0			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr9:21971000C>A	uc003zpk.2	-	2	570	c.358G>T	c.(358-360)GAG>TAG	p.E120*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_3'UTR	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	120	ANK 4.		E -> A (in non-small cell lung carcinoma).|E -> K (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E120*(8)|p.E120K(4)|p.E120A(1)|p.A118fs*10(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGGCCCAGCTCCTCAGCCAGG	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			19	23					2.35188e-11	4.65031e-11	1	0	A	21971000	A	A	21971000	4	1	280	1	0	0	0	0	0	1	0	0	3176	864	30	2	120	2	CDKN2A	9	21971000	Nonsense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08		21971000	119242431	47	52340											
PTCH1	5727	broad.mit.edu	37	chr9	98229683	98229683	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaggctgacccccagcaagcCcagaaaaaggaagatcacca	17	2	9	13	0	1	3	1	1	0	2	1	4	1	4	4	2	2	2	4	2	5	0			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr9:98229683C>G	uc004avk.3	-	15	2463	c.2275G>C	c.(2275-2277)GGC>CGC	p.G759R	PTCH1_uc010mro.2_Missense_Mutation_p.G608R|PTCH1_uc010mrp.2_Missense_Mutation_p.G608R|PTCH1_uc010mrq.2_Missense_Mutation_p.G608R|PTCH1_uc004avl.3_Missense_Mutation_p.G608R|PTCH1_uc010mrr.2_Missense_Mutation_p.G693R|PTCH1_uc004avm.3_Missense_Mutation_p.G758R	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	759	Helical; (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CCCAGCAAGCCCAGAAAAAGG	0.527									Basal_Cell_Nevus_syndrome				19	32					0	0	0	0	G	98229683	G	G	98229683	3	3	280	1	0	0	0	0	1	0	0	0	12792	623	22	4	2104	4	PTCH1	9	98229683	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	76258683	98229683	42983748	48	52341											
GSN	2934	broad.mit.edu	37	chr9	124091523	124091523	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttccttcccagatcgaagAggttcctggtgagctcatgc	7	11	11	12	2	1	3	1	1	0	2	5	4	4	3	3	2	2	3	3	2	1	3			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr9:124091523A>G	uc004blf.1	+	15	2109	c.2048A>G	c.(2047-2049)GAG>GGG	p.E683G	GSN_uc004bld.1_Missense_Mutation_p.E632G|GSN_uc010mvq.1_Missense_Mutation_p.E643G|GSN_uc010mvr.1_Missense_Mutation_p.E643G|GSN_uc010mvu.1_Missense_Mutation_p.E632G|GSN_uc010mvt.1_Missense_Mutation_p.E632G|GSN_uc010mvs.1_Missense_Mutation_p.E632G|GSN_uc004ble.1_Missense_Mutation_p.E632G|GSN_uc010mvv.1_Missense_Mutation_p.E632G|GSN_uc011lyh.1_Missense_Mutation_p.E649G|GSN_uc011lyi.1_Missense_Mutation_p.E632G|GSN_uc011lyj.1_Missense_Mutation_p.E656G|GSN_uc004blg.1_Missense_Mutation_p.E414G	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	683	Actin-binding, Ca-sensitive (Potential).|Gelsolin-like 6.				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						CAGATCGAAGAGGTTCCTGGT	0.577													35	40					0	0	0	0	G	124091523	G	G	124091523	3	3	280	1	0	0	0	0	1	0	0	0	6864	304	11	5	2134	5	GSN	9	124091523	Missense_Mutation	SNP	A	TCGA-D6-6825-01A-21D-1912-08	25861840	124091523	17121908	49	52342											
PLXDC2	84898	broad.mit.edu	37	chr10	20357118	20357118	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagtgaatctgtccttcgAttttccattttatggccact	8	16	8	9	1	1	2	0	1	1	1	4	4	3	2	3	1	0	0	3	1	2	5			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr10:20357118A>G	uc001iqg.1	+	4	1128	c.491A>G	c.(490-492)GAT>GGT	p.D164G	PLXDC2_uc001iqh.1_Missense_Mutation_p.D115G	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	164	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						CTGTCCTTCGATTTTCCATTT	0.393													6	48					0	0	0	0	G	20357118	G	G	20357118	3	3	280	1	0	0	0	0	1	0	0	0	12173	333	12	5	505	5	PLXDC2	10	20357118	Missense_Mutation	SNP	A	TCGA-D6-6825-01A-21D-1912-08		20357118	115177629	50	52343											
RHOBTB1	9886	broad.mit.edu	37	chr10	62647977	62647977	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcggcccactcacccgagaaCgttcccttgctgagacactc	8	7	9	17	3	1	2	1	1	0	2	3	4	2	2	3	1	2	2	3	1	1	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr10:62647977C>T	uc001jli.2	-	7	1887	c.1449G>A	c.(1447-1449)ACG>ACA	p.T483T	RHOBTB1_uc001jlh.2_Silent_p.T483T|RHOBTB1_uc001jlj.2_Silent_p.T483T|RHOBTB1_uc001jlk.2_Silent_p.T483T|RHOBTB1_uc009xpe.1_Silent_p.T421T|RHOBTB1_uc001jll.2_Silent_p.T233T	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	483					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					CACCCGAGAACGTTCCCTTGC	0.443													4	19					0	0	0	0	T	62647977	T	T	62647977	2	4	280	1	0	0	0	0	0	0	0	1	13398	523	19	1		1	RHOBTB1	10	62647977	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08	42290859	62647977	72886770	51	52344											
PRF1	5551	broad.mit.edu	37	chr10	72358341	72358341	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgccctggtgggcacggcCggctgcagtccctccagcga	4	5	15	17	4	0	0	0	0	0	0	2	1	2	0	5	4	2	3	5	4	0	0			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr10:72358341C>T	uc009xqg.2	-	3	1297	c.1136G>A	c.(1135-1137)CGG>CAG	p.R379Q	PRF1_uc001jrf.3_Missense_Mutation_p.R379Q	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	379	EGF-like.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TGGGCACGGCCGGCTGCAGTC	0.701			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				4	22					0	0	0	0	T	72358341	T	T	72358341	3	4	280	1	0	0	0	0	1	0	0	0	12540	652	23	1	535	1	PRF1	10	72358341	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	9710364	72358341	63176406	52	52345											
DOCK1	1793	broad.mit.edu	37	chr10	129209186	129209186	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacccagacaatgaatttGcggtaaaaaacaaacaaacc	22	5	5	9	1	0	2	0	1	0	1	0	2	0	2	2	1	5	1	2	1	9	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr10:129209186G>A	uc001ljt.2	+	43	4427	c.4363G>A	c.(4363-4365)GCG>ACG	p.A1455T	DOCK1_uc010qun.1_Missense_Mutation_p.A1476T|DOCK1_uc009yaq.2_Missense_Mutation_p.A450T	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1455	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CAATGAATTTGCGGTAAAAAA	0.468													8	21					0	0	0	0	A	129209186	A	A	129209186	3	1	280	1	0	0	0	0	1	0	0	0	4706	1319	46	4	4533	4	DOCK1	10	129209186	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	56850845	129209186	6325561	53	52346											
SBF2	81846	broad.mit.edu	37	chr11	10064502	10064502	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcttcctctctctggaCagctgccacccgccaggctg	4	9	11	17	1	2	0	0	0	2	0	4	1	3	1	4	3	3	4	4	3	0	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr11:10064502C>A	uc001mib.2	-	3	306	c.168G>T	c.(166-168)CTG>CTT	p.L56L	SBF2_uc001mif.3_5'UTR|SBF2_uc001mij.2_RNA	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	56	UDENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TCTCTCTGGACAGCTGCCACC	0.378													11	45					0.000219431	0.000385667	1	0	A	10064502	A	A	10064502	2	1	280	1	0	0	0	0	0	0	0	1	13924	465	17	4		4	SBF2	11	10064502	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08		10064502	124942014	54	52347											
NAV2	89797	broad.mit.edu	37	chr11	20139697	20139697	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgaacatgctgatgaggCtgcaggaggcagccaactac	13	6	13	9	0	0	4	0	3	0	1	0	5	0	5	1	3	6	4	1	3	3	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr11:20139697C>T	uc001mpr.3	+	38	7553	c.7192C>T	c.(7192-7194)CTG>TTG	p.L2398L	NAV2_uc001mpp.2_Silent_p.L2331L|NAV2_uc009yhx.2_Silent_p.L1459L|NAV2_uc009yhz.2_Silent_p.L1040L|NAV2_uc001mpu.2_Silent_p.L833L|NAV2_uc001mpv.2_Silent_p.L157L	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	2454						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GCTGATGAGGCTGCAGGAGGC	0.552													15	87					0	0	0	0	T	20139697	T	T	20139697	2	4	280	1	0	0	0	0	0	0	0	1	10237	796	28	4		4	NAV2	11	20139697	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08	10075195	20139697	114866819	55	52348											
FIBIN	387758	broad.mit.edu	37	chr11	27016517	27016517	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agcaagttcaagcagggccaGgaacaggacagccggcagga	14	2	15	10	1	1	0	1	0	0	0	1	3	1	3	2	5	4	4	2	5	3	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr11:27016517G>A	uc001mrd.2	+	1	890	c.444G>A	c.(442-444)CAG>CAA	p.Q148Q		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	148						extracellular region|Golgi apparatus					0						AGCAGGGCCAGGAACAGGACA	0.592													10	44					0	0	0	0	A	27016517	A	A	27016517	2	1	280	1	0	0	0	0	0	0	0	1	5917	991	35	4		4	FIBIN	11	27016517	Silent	SNP	G	TCGA-D6-6825-01A-21D-1912-08	6876820	27016517	107989999	56	52349											
CLSTN3	9746	broad.mit.edu	37	chr12	7289595	7289595	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggctgggctctgggcccCaggacagcctcagtgaccac	6	6	15	14	0	2	1	1	1	1	0	2	2	2	2	4	4	1	2	4	4	0	0			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr12:7289595C>A	uc001qsr.2	+	7	1377	c.1099C>A	c.(1099-1101)CAG>AAG	p.Q367K	CLSTN3_uc001qss.2_Missense_Mutation_p.Q379K	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	367	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						CTCTGGGCCCCAGGACAGCCT	0.592													18	57					3.41278e-10	6.67218e-10	1	0	A	7289595	A	A	7289595	3	1	280	1	0	0	0	0	1	0	0	0	3578	595	21	4	1125	4	CLSTN3	12	7289595	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08		7289595	126562300	57	52350											
CD163L1	283316	broad.mit.edu	37	chr12	7522012	7522012	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cactctgtccccagggtttgGcgtgacagtcccatagaaat	9	10	10	12	1	1	2	0	1	1	1	3	2	3	2	3	2	0	1	3	2	2	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr12:7522012G>A	uc001qsy.2	-	15	4006	c.3980C>T	c.(3979-3981)GCC>GTC	p.A1327V	CD163L1_uc010sge.1_Missense_Mutation_p.A1337V	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1327	SRCR 12.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CCAGGGTTTGGCGTGACAGTC	0.537													34	91					0	0	0	0	A	7522012	A	A	7522012	3	1	280	1	0	0	0	0	1	0	0	0	2983	1203	42	4	401	4	CD163L1	12	7522012	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	232417	7522012	126329883	58	52351											
GRIN2B	2904	broad.mit.edu	37	chr12	13715993	13715993	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatggagcaagcactggtcGtccccaaaagtggggatgaa	12	6	13	10	1	0	1	0	1	0	0	2	3	1	3	3	4	2	2	3	4	4	0			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr12:13715993G>A	uc001rbt.2	-	13	4358	c.4179C>T	c.(4177-4179)GAC>GAT	p.D1393D		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1393	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGCACTGGTCGTCCCCAAAAG	0.617													9	43					0	0	0	0	A	13715993	A	A	13715993	2	1	280	1	0	0	0	0	0	0	0	1	6819	1136	40	1		1	GRIN2B	12	13715993	Silent	SNP	G	TCGA-D6-6825-01A-21D-1912-08	6193981	13715993	120135902	59	52352											
C14orf105	55195	broad.mit.edu	37	chr14	57938207	57938207	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcccagagaagctgtccctGggcctcttgttcatgaagcc	7	10	11	13	0	2	2	1	1	1	1	4	3	4	2	4	1	2	2	4	1	2	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr14:57938207G>A	uc001xcy.2	-	6	900	c.757C>T	c.(757-759)CAG>TAG	p.Q253*	C14orf105_uc010trl.1_Nonsense_Mutation_p.Q293*|C14orf105_uc010trm.1_Nonsense_Mutation_p.Q164*|C14orf105_uc010trn.1_Nonsense_Mutation_p.Q164*|C14orf105_uc001xcz.2_Nonsense_Mutation_p.Q252*	NM_018168	NP_060638	Q9NVL8	CN105_HUMAN	hypothetical protein LOC55195	253											0						AGCTGTCCCTGGGCCTCTTGT	0.453													4	48					0	0	0	0	A	57938207	A	A	57938207	4	1	280	1	0	0	0	0	0	1	0	0	1743	1357	47	4	137	4	C14orf105	14	57938207	Nonsense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08		57938207	49411333	60	52353											
FLVCR2	55640	broad.mit.edu	37	chr14	76088433	76088433	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttctatagcttggaattgcGattgggttcttggtccctcc	5	16	10	10	1	2	0	0	0	2	0	4	2	4	1	2	3	2	2	2	3	3	8	rs143118396		TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr14:76088433G>A	uc001xrs.2	+	2	1057	c.681G>A	c.(679-681)GCG>GCA	p.A227A	FLVCR2_uc010tvd.1_Silent_p.A22A	NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	227	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		TTGGAATTGCGATTGGGTTCT	0.433													33	208					0	0	0	0	A	76088433	A	A	76088433	2	1	280	1	0	0	0	0	0	0	0	1	5978	1045	37	1		1	FLVCR2	14	76088433	Silent	SNP	G	TCGA-D6-6825-01A-21D-1912-08	18150226	76088433	31261107	61	52354											
GABRB3	2562	broad.mit.edu	37	chr15	26866602	26866602	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagccactcgattgtcaagcGtgaggttgagagggatccca	10	8	13	10	2	1	2	1	2	0	1	3	5	2	3	2	2	2	1	2	2	1	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr15:26866602G>A	uc001zaz.2	-	4	462	c.320C>T	c.(319-321)ACG>ATG	p.T107M	GABRB3_uc010uae.1_Missense_Mutation_p.T22M|GABRB3_uc001zba.2_Missense_Mutation_p.T107M|GABRB3_uc001zbb.2_Missense_Mutation_p.T163M|GABRB3_uc001zbc.2_RNA	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	107	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATTGTCAAGCGTGAGGTTGAG	0.428													18	76					0	0	0	0	A	26866602	A	A	26866602	3	1	280	1	0	0	0	0	1	0	0	0	6202	1145	40	1	1125	1	GABRB3	15	26866602	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08		26866602	75664790	62	52355											
RYR3	6263	broad.mit.edu	37	chr15	34105782	34105782	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctctacaacctgcccaggCaagtattttgtcttttttcc	7	16	5	13	0	2	0	0	0	2	0	4	0	3	0	3	1	3	2	3	1	4	7			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr15:34105782C>A	uc001zhi.2	+	74	10572	c.10502_splice	c.e74+2	p.R3501_splice	RYR3_uc010bar.2_Splice_Site_p.R3496_splice	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCTGCCCAGGCAAGTATTTTG	0.502													14	62					4.3838e-07	8.02928e-07	1	0	A	34105782	A	A	34105782	5	1	280	1	0	0	0	0	0	0	1	0	13835	724	25	4	10798	4	RYR3	15	34105782	Splice_Site	SNP	C	TCGA-D6-6825-01A-21D-1912-08	7239180	34105782	68425610	63	52356											
NUSAP1	51203	broad.mit.edu	37	chr15	41643315	41643315	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcaccaagaagctgagaatGctgtttcctcaggtaaacgt	13	9	10	9	1	1	2	1	1	0	2	2	3	2	2	2	1	4	5	2	1	5	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr15:41643315G>A	uc001zns.3	+	4	666	c.436G>A	c.(436-438)GCT>ACT	p.A146T	NUSAP1_uc001znq.3_5'UTR|NUSAP1_uc001znr.3_Missense_Mutation_p.A146T|NUSAP1_uc010bce.2_Missense_Mutation_p.A146T|NUSAP1_uc001znt.3_Missense_Mutation_p.A131T|NUSAP1_uc001znv.3_Missense_Mutation_p.A145T|NUSAP1_uc001znu.3_Missense_Mutation_p.A145T|NUSAP1_uc010ucw.1_Missense_Mutation_p.A123T|NUSAP1_uc001znw.3_5'UTR	NM_016359	NP_057443	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	146					cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding				0		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		AGCTGAGAATGCTGTTTCCTC	0.383													8	31					0	0	0	0	A	41643315	A	A	41643315	3	1	280	1	0	0	0	0	1	0	0	0	10832	1319	46	4	450	4	NUSAP1	15	41643315	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	7537533	41643315	60888077	64	52357											
TEKT5	146279	broad.mit.edu	37	chr16	10788316	10788316	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcctctggcccaggttccGgcaggtgccctcctgcatct	4	9	11	17	1	2	0	0	0	2	0	4	0	4	0	5	4	3	3	5	4	0	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr16:10788316G>A	uc002czz.1	-	1	487	c.415C>T	c.(415-417)CGG>TGG	p.R139W		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	139	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						CCCAGGTTCCGGCAGGTGCCC	0.617													5	175					0	0	0	0	A	10788316	A	A	10788316	3	1	280	1	0	0	0	0	1	0	0	0	15822	1115	39	1	1070	1	TEKT5	16	10788316	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08		10788316	79566437	65	52358											
TMCO7	79613	broad.mit.edu	37	chr16	68914511	68914511	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacagaagaagaacttagtaGatgcattgaggatgtgttta	15	11	12	3	0	0	5	0	1	0	4	0	7	0	6	0	1	2	3	0	1	6	5			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr16:68914511G>A	uc002ewi.3	+	7	1367	c.1355G>A	c.(1354-1356)AGA>AAA	p.R452K		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	452						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		GAACTTAGTAGATGCATTGAG	0.279													19	76					0	0	0	0	A	68914511	A	A	68914511	3	1	280	1	0	0	0	0	1	0	0	0	16067	942	33	2	1381	2	TMCO7	16	68914511	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	58126195	68914511	21440242	66	52359											
TP53	7157	broad.mit.edu	37	chr17	7578369	7578369	+	Splice_Site	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctccagccccagctgctcAccatcgctatctgagcagcg	7	8	8	18	2	3	1	1	1	2	0	5	1	3	1	4	0	5	4	4	0	1	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr17:7578369A>C	uc002gim.2	-	5	753	c.559_splice	c.e5+1	p.G187_splice	TP53_uc002gig.1_Splice_Site_p.G187_splice|TP53_uc002gih.2_Splice_Site_p.G187_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Intron|TP53_uc010cng.1_Intron|TP53_uc002gii.1_Intron|TP53_uc010cnh.1_Splice_Site_p.G187_splice|TP53_uc010cni.1_Splice_Site_p.G187_splice|TP53_uc002gij.2_Splice_Site_p.G187_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Splice_Site_p.G94_splice|TP53_uc002gio.2_Splice_Site_p.G55_splice|TP53_uc010vug.1_Splice_Site_p.G148_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(12)|p.0?(7)|p.G187fs*16(2)|p.D186_P191delDGLAPP(1)|p.L188fs*19(1)|p.G187_L188delGL(1)|p.G187fs*22(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCAGCTGCTCACCATCGCTAT	0.632		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	28					0	0	0	0	C	7578369	C	C	7578369	5	2	280	1	0	0	0	0	0	0	1	0	16448	173	6	5	737	5	TP53	17	7578369	Splice_Site	SNP	A	TCGA-D6-6825-01A-21D-1912-08		7578369	73616841	67	52360											
PSMD11	5717	broad.mit.edu	37	chr17	30771555	30771555	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtaagatggcggcggcggCggtggtggagttccagagag	7	6	21	7	5	0	2	0	0	0	2	1	4	1	3	1	8	0	2	1	8	1	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr17:30771555C>G	uc010cta.1	+	1	54	c.14C>G	c.(13-15)GCG>GGG	p.A5G	PSMD11_uc010wbz.1_Missense_Mutation_p.A5G|PSMD11_uc002hhm.2_Missense_Mutation_p.A5G	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	5					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			gcggcggcggcggtggtggAG	0.373													10	11					0	0	0	0	G	30771555	G	G	30771555	3	3	280	1	0	0	0	0	1	0	0	0	12756	768	27	3	16	3	PSMD11	17	30771555	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	23193186	30771555	50423655	68	52361											
EME1	146956	broad.mit.edu	37	chr17	48452586	48452586	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgatggctctaaagaagtCatcaccctcactggattctg	11	11	8	11	0	5	2	3	1	2	1	5	3	5	3	1	2	0	1	1	2	3	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr17:48452586C>T	uc002iqs.1	+	2	90	c.17C>T	c.(16-18)TCA>TTA	p.S6L	MRPL27_uc002iqq.2_5'Flank|MRPL27_uc002iqr.2_5'Flank|EME1_uc010dbp.1_Missense_Mutation_p.S6L	NM_152463	NP_689676	Q96AY2	EME1_HUMAN	essential meiotic endonuclease 1 homolog 1	6					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding				0	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			CTAAAGAAGTCATCACCCTCA	0.428								Direct_reversal_of_damage|Homologous_recombination					13	58					0	0	0	0	T	48452586	T	T	48452586	3	4	280	1	0	0	0	0	1	0	0	0	5112	838	29	2	19	2	EME1	17	48452586	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	17681031	48452586	32742624	69	52362											
PPM1E	22843	broad.mit.edu	37	chr17	57050198	57050198	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcattgctgtttaggatgaAaagcagagaattgaggccct	12	11	12	6	0	0	3	0	2	0	1	0	5	0	4	1	2	3	4	1	2	4	4			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr17:57050198A>G	uc002iwx.2	+	6	1249	c.1122A>G	c.(1120-1122)GAA>GAG	p.E374E	PPM1E_uc010ddd.2_Silent_p.E137E	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	383	PP2C-like.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			TTTAGGATGAAAAGCAGAGAA	0.398													31	49					0	0	0	0	G	57050198	G	G	57050198	2	3	280	1	0	0	0	0	0	0	0	1	12398	11	1	5		5	PPM1E	17	57050198	Silent	SNP	A	TCGA-D6-6825-01A-21D-1912-08	8597612	57050198	24145012	70	52363											
TRIM37	4591	broad.mit.edu	37	chr17	57158492	57158492	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctgatcagttccatgagaCgccgacgaagtttggctacc	10	9	11	11	3	1	2	1	2	0	1	2	5	2	2	3	1	2	4	3	1	2	3			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr17:57158492C>T	uc002iwy.3	-	6	902	c.458G>A	c.(457-459)CGT>CAT	p.R153H	TRIM37_uc002iwz.3_Missense_Mutation_p.R153H|TRIM37_uc002ixa.3_Missense_Mutation_p.R31H|TRIM37_uc010woc.1_Missense_Mutation_p.R119H	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	153	Potential.					perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TTCCATGAGACGCCGACGAAG	0.299									Mulibrey_Nanism				40	55					0	0	0	0	T	57158492	T	T	57158492	3	4	280	1	0	0	0	0	1	0	0	0	16578	536	19	1	2520	1	TRIM37	17	57158492	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08	108294	57158492	24036718	71	52364											
ABCA10	10349	broad.mit.edu	37	chr17	67160232	67160232	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactattaaggttgttaaaaGaatggttttattgacttcat	13	18	7	3	0	1	2	1	1	0	1	1	2	1	2	0	2	1	3	0	2	7	9			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr17:67160232G>C	uc010dfa.1	-	28	4225	c.3346C>G	c.(3346-3348)CTT>GTT	p.L1116V	ABCA10_uc010wqs.1_Missense_Mutation_p.L108V|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1116	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GTTGTTAAAAGAATGGTTTTA	0.313													11	39					0	0	0	0	C	67160232	C	C	67160232	3	2	280	1	0	0	0	0	1	0	0	0	29	942	33	2	1337	2	ABCA10	17	67160232	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	10001740	67160232	14034978	72	52365											
SDK2	54549	broad.mit.edu	37	chr17	71375666	71375666	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacacgctcatccgtatctcGtaccgcctgtgcttgttcag	6	13	8	14	4	3	0	2	0	1	0	5	0	4	0	3	0	3	5	3	0	3	5	rs141328074		TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr17:71375666G>A	uc010dfm.2	-	35	4785	c.4785C>T	c.(4783-4785)TAC>TAT	p.Y1595Y	SDK2_uc002jjt.3_Silent_p.Y735Y|SDK2_uc010dfn.2_Silent_p.Y1274Y	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1595	Extracellular (Potential).|Fibronectin type-III 10.				cell adhesion	integral to membrane				ovary(2)	2						TCCGTATCTCGTACCGCCTGT	0.652													5	44					0	0	0	0	A	71375666	A	A	71375666	2	1	280	1	0	0	0	0	0	0	0	1	14034	1140	40	1		1	SDK2	17	71375666	Silent	SNP	G	TCGA-D6-6825-01A-21D-1912-08	4215434	71375666	9819544	73	52366											
ALKBH7	84266	broad.mit.edu	37	chr19	6374915	6374915	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccggggccggcgcatctcCgtgatctgccgctccctccc	2	7	11	21	5	2	1	0	1	2	0	5	1	4	1	7	3	1	2	7	3	0	0			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr19:6374915C>G	uc002meo.1	+	4	985	c.597C>G	c.(595-597)TCC>TCG	p.S199S		NM_032306	NP_115682	Q9BT30	ALKB7_HUMAN	spermatogenesis associated 11 precursor	199						extracellular region|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GGCGCATCTCCGTGATCTGCC	0.637													15	41					0	0	0	0	G	6374915	G	G	6374915	2	3	280	1	0	0	0	0	0	0	0	1	532	639	23	3		3	ALKBH7	19	6374915	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08		6374915	52754068	74	52367											
ZNF536	9745	broad.mit.edu	37	chr19	31039973	31039973	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggatgtccccatcctgatCcccgaaaccacgagtaagaa	13	6	9	13	2	0	2	0	1	0	1	3	6	3	3	6	1	1	1	6	1	3	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr19:31039973C>A	uc002nsu.1	+	4	3585	c.3447C>A	c.(3445-3447)ATC>ATA	p.I1149I	ZNF536_uc010edd.1_Silent_p.I1149I	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCATCCTGATCCCCGAAACCA	0.552													12	59					2.80697e-09	5.36718e-09	1	0	A	31039973	A	A	31039973	2	1	280	1	0	0	0	0	0	0	0	1	18041	845	30	2		2	ZNF536	19	31039973	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08	24665058	31039973	28089010	75	52368											
KCTD15	79047	broad.mit.edu	37	chr19	34297787	34297787	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggataagccgcctcttcaatGgcactgaacccatcgtcctg	9	9	9	14	2	2	1	1	1	1	0	4	2	3	2	4	2	2	1	4	2	3	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr19:34297787G>A	uc002nuy.3	+	5	530	c.262G>A	c.(262-264)GGC>AGC	p.G88S	KCTD15_uc002nuv.2_Missense_Mutation_p.G88S|KCTD15_uc002nuw.3_Missense_Mutation_p.G88S|KCTD15_uc010xrt.1_Missense_Mutation_p.G88S|KCTD15_uc002nux.3_Missense_Mutation_p.G88S	NM_001129994	NP_001123466	Q96SI1	KCD15_HUMAN	potassium channel tetramerisation domain	88	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	Esophageal squamous(110;0.162)					CCTCTTCAATGGCACTGAACC	0.567													17	120					0	0	0	0	A	34297787	A	A	34297787	3	1	280	1	0	0	0	0	1	0	0	0	8141	1348	47	4	272	4	KCTD15	19	34297787	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	3257814	34297787	24831196	76	52369											
FAM98C	147965	broad.mit.edu	37	chr19	38897630	38897630	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggacatctccattgcacaCgttctggctgcccgagccga	7	9	10	15	4	2	0	0	0	2	0	4	3	2	1	3	2	3	3	3	2	0	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr19:38897630C>T	uc002oin.1	+	7	850	c.831C>T	c.(829-831)CAC>CAT	p.H277H	FAM98C_uc002oio.1_Intron|FAM98C_uc010xtz.1_Missense_Mutation_p.R144C	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	277										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCATTGCACACGTTCTGGCTG	0.612													32	102					0	0	0	0	T	38897630	T	T	38897630	2	4	280	1	0	0	0	0	0	0	0	1	5690	535	19	1		1	FAM98C	19	38897630	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08	4599843	38897630	20231353	77	52370											
SHANK1	50944	broad.mit.edu	37	chr19	51171632	51171634	+	In_Frame_Del	DEL	GCC	-	-																															ggggcggggctgggcgaggaGccgccgccgccgccgcctcc																										TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr19:51171632_51171634delGCC	uc002psx.1	-	22	3602_3604	c.3583_3585delGGC	c.(3583-3585)GGCdel	p.G1195del	SHANK1_uc002psw.1_In_Frame_Del_p.G579del	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1195	Poly-Gly.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		tgggcgaggAGCCGCCGCCGCCG	0.493													---	---	---								-	51171634	-	-	51171632	7	5	280	1	0	1	0	1	0	0	0	0	14329	958	34	0	2908	0	SHANK1	19	51171632	In_Frame_Del	DEL	GCC	TCGA-D6-6825-01A-21D-1912-08	12274002	51171632	7957351	78	52371											
NLRP7	199713	broad.mit.edu	37	chr19	55435180	55435180	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaatagtcagcttgggattCttttctttcacttcctccaa	8	17	5	11	0	5	0	3	0	2	0	7	1	7	1	2	1	1	1	2	1	3	7			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr19:55435180C>T	uc002qih.3	-	10	2947	c.2871G>A	c.(2869-2871)AAG>AAA	p.K957K	NLRP7_uc002qig.3_Silent_p.K986K|NLRP7_uc002qii.3_Silent_p.K1014K|NLRP7_uc010esk.2_3'UTR|NLRP7_uc010esl.2_Silent_p.K1042K	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	957	LRR 9.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GCTTGGGATTCTTTTCTTTCA	0.448													35	67					0	0	0	0	T	55435180	T	T	55435180	2	4	280	1	0	0	0	0	0	0	0	1	10536	912	32	2		2	NLRP7	19	55435180	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08	4263548	55435180	3693803	79	52372											
NLRP5	126206	broad.mit.edu	37	chr19	56520174	56520174	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacattcaccagaagatcctGaagcaacgatgactgaccaa	16	6	8	11	1	1	5	1	3	0	2	2	7	2	5	3	0	2	1	3	0	4	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr19:56520174G>C	uc002qmj.2	+	3	463	c.463G>C	c.(463-465)GAA>CAA	p.E155Q	NLRP5_uc002qmi.2_Missense_Mutation_p.E155Q	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	155						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		AGAAGATCCTGAAGCAACGAT	0.388													3	22					0	0	0	0	C	56520174	C	C	56520174	3	2	280	1	0	0	0	0	1	0	0	0	10534	1291	45	2	473	2	NLRP5	19	56520174	Missense_Mutation	SNP	G	TCGA-D6-6825-01A-21D-1912-08	1084994	56520174	2608809	80	52373											
RRBP1	6238	broad.mit.edu	37	chr20	17623695	17623695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagccgctgggcctcgccctCgttgaacaccatgctcccaa	7	7	10	17	3	0	1	0	1	0	0	3	2	1	1	5	1	3	3	5	1	2	1	rs144923230		TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr20:17623695C>T	uc002wpv.1	-	5	1045	c.691G>A	c.(691-693)GAG>AAG	p.E231K	RRBP1_uc002wpu.2_Missense_Mutation_p.E5K|RRBP1_uc002wpw.1_Missense_Mutation_p.E231K|RRBP1_uc010gcl.1_Missense_Mutation_p.E5K	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	664	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						GCCTCGCCCTCGTTGAACACC	0.632													10	31					0	0	0	0	T	17623695	T	T	17623695	3	4	280	1	0	0	0	0	1	0	0	0	13743	893	31	1	2330	1	RRBP1	20	17623695	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08		17623695	45401825	81	52374											
PAX1	5075	broad.mit.edu	37	chr20	21687260	21687260	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcgcgctacaacgagacCggctccattctgcccggggc	6	6	13	16	5	1	1	0	0	1	1	2	2	2	1	3	4	3	2	3	4	2	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr20:21687260C>T	uc002wsj.2	+	2	525	c.471C>T	c.(469-471)ACC>ACT	p.T157T	PAX1_uc010zsl.1_Silent_p.T157T|PAX1_uc010zsm.1_Silent_p.T133T	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	157	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						ACAACGAGACCGGCTCCATTC	0.657													13	52					0	0	0	0	T	21687260	T	T	21687260	2	4	280	1	0	0	0	0	0	0	0	1	11532	639	23	1		1	PAX1	20	21687260	Silent	SNP	C	TCGA-D6-6825-01A-21D-1912-08	4063565	21687260	41338260	82	52375											
TRPM2	7226	broad.mit.edu	37	chr21	45820227	45820227	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcatgctggccttcccgcTgctcctcaccggcctcatct	3	11	9	18	2	3	0	2	0	1	0	5	0	5	0	5	2	3	4	5	2	0	1			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chr21:45820227T>G	uc002zet.1	+	16	2507	c.2294T>G	c.(2293-2295)CTG>CGG	p.L765R	TRPM2_uc002zeu.1_Missense_Mutation_p.L765R|TRPM2_uc002zew.1_Missense_Mutation_p.L765R|TRPM2_uc010gpt.1_Missense_Mutation_p.L765R|TRPM2_uc002zex.1_Missense_Mutation_p.L551R|TRPM2_uc002zey.1_Missense_Mutation_p.L278R	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	765	Helical; (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCCTTCCCGCTGCTCCTCACC	0.498													11	22					0	0	0	0	G	45820227	G	G	45820227	3	3	280	1	0	0	0	0	1	0	0	0	16653	1580	55	5	2352	5	TRPM2	21	45820227	Missense_Mutation	SNP	T	TCGA-D6-6825-01A-21D-1912-08		45820227	2309668	83	52376											
SCML2	10389	broad.mit.edu	37	chrX	18323203	18323203	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaagctccactccagccatCaaatgtgatatgaacttcat	15	10	5	11	0	2	2	2	2	0	0	4	2	4	2	3	0	3	1	3	0	5	2			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chrX:18323203C>T	uc004cyl.2	-	7	776	c.619G>A	c.(619-621)GAT>AAT	p.D207N	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.D207N|SCML2_uc011miz.1_Missense_Mutation_p.D141N	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	207	MBT 2.				anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					CTCCAGCCATCAAATGTGATA	0.458													50	74					0	0	0	0	T	18323203	T	T	18323203	3	4	280	1	0	0	0	0	1	0	0	0	13975	826	29	2	1519	2	SCML2	23	18323203	Missense_Mutation	SNP	C	TCGA-D6-6825-01A-21D-1912-08		18323203	136947357	84	52377											
PTCHD1	139411	broad.mit.edu	37	chrX	23411904	23411904	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actgcatttctgtgctatgcTtaatttatggaattaattac	11	18	6	6	0	1	0	0	0	1	0	1	1	1	1	0	1	4	3	0	1	6	7			TCGA-D6-6825-01A-21D-1912-08	TCGA-D6-6825-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f44db3-84dc-4f96-888d-b0370bf582a5	250f6e68-3d67-48ee-a501-4d91e13dc854	g.chrX:23411904T>G	uc004dal.3	+	3	2277	c.2269T>G	c.(2269-2271)TTA>GTA	p.L757V		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	757	Helical; (Potential).				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						TGTGCTATGCTTAATTTATGG	0.378													19	22					0	0	0	0	G	23411904	G	G	23411904	3	3	280	1	0	0	0	0	1	0	0	0	12794	1606	56	5	2279	5	PTCHD1	23	23411904	Missense_Mutation	SNP	T	TCGA-D6-6825-01A-21D-1912-08	5088701	23411904	131858656	85	52378											
KLHDC7A	127707	broad.mit.edu	37	chr1	18809462	18809462	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctggtgggccggccccaccGggggcagcaaggaccgcacg	6	2	18	15	4	0	0	0	0	0	0	0	1	0	1	5	6	1	4	5	6	1	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:18809462G>A	uc001bax.2	+	1	2039	c.1987G>A	c.(1987-1989)GGG>AGG	p.G663R	KLHDC7A_uc009vpg.2_Missense_Mutation_p.G445R	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	663	Kelch 5.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CGGCCCCACCGGGGGCAGCAA	0.677													11	27					0	0	0	0	A	18809462	A	A	18809462	3	1	281	1	0	0	0	0	1	0	0	0	8399	1116	39	1	1989	1	KLHDC7A	1	18809462	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08		18809462	230441159	1	52379											
MAP3K6	9064	broad.mit.edu	37	chr1	27690468	27690468	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcggggctcagcagctccacGctgtccagtctccgctgcag	5	8	12	16	3	2	0	1	0	1	0	6	0	4	0	3	2	3	6	3	2	0	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:27690468G>A	uc001bny.1	-	5	1053	c.804C>T	c.(802-804)AGC>AGT	p.S268S	MAP3K6_uc009vsw.1_Silent_p.S260S|MAP3K6_uc001bnz.1_5'Flank	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	268					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GCAGCTCCACGCTGTCCAGTC	0.537													7	17					0	0	0	0	A	27690468	A	A	27690468	2	1	281	1	0	0	0	0	0	0	0	1	9307	1078	38	1		1	MAP3K6	1	27690468	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08	8881006	27690468	221560153	2	52380											
C1orf175	374977	broad.mit.edu	37	chr1	55148401	55148401	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtccgagacctcctggatctGctcctgggcagcctgaagga	7	8	13	13	1	1	2	0	1	1	1	4	5	4	4	5	3	2	2	5	3	1	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:55148401G>T	uc010ooe.1	+	14	2778	c.2454G>T	c.(2452-2454)CTG>CTT	p.L818L	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Silent_p.L386L|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Silent_p.L336L|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Silent_p.L818L|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_Intron|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Silent_p.L20L	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	818						integral to membrane	binding				0						TCCTGGATCTGCTCCTGGGCA	0.612													19	39					2.35188e-11	4.55935e-11	1	0	T	55148401	T	T	55148401	2	4	281	1	0	0	0	0	0	0	0	1	2025	1306	46	4		4	C1orf175	1	55148401	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08	27457933	55148401	194102220	3	52381											
LRRC7	57554	broad.mit.edu	37	chr1	70502126	70502126	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttcccctttaaatttcaGaatcaactgatgagtctgaa	13	15	5	8	0	3	4	2	3	1	1	4	4	4	4	2	0	1	0	2	0	5	5			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:70502126G>T	uc001dep.2	+	18	2024	c.1994_splice	c.e18-1	p.E665_splice	LRRC7_uc009wbg.2_Intron|LRRC7_uc001deq.2_5'Flank	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7							centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TTAAATTTCAGAATCAACTGA	0.393													13	30					0.000151284	0.000263259	1	0	T	70502126	T	T	70502126	5	4	281	1	0	0	0	0	0	0	1	0	9070	956	33	2	2063	2	LRRC7	1	70502126	Splice_Site	SNP	G	TCGA-D6-6826-01A-11D-1912-08	15353725	70502126	178748495	4	52382											
NEXN	91624	broad.mit.edu	37	chr1	78392542	78392542	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caagaaaacgtttagaagaaGagaagcgtgcttttgaagaa	18	8	11	4	2	0	6	0	1	0	5	0	7	0	6	0	0	3	2	0	0	9	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:78392542G>C	uc001dic.3	+	8	1126	c.829G>C	c.(829-831)GAG>CAG	p.E277Q	NEXN_uc001dia.3_Missense_Mutation_p.E263Q|NEXN_uc009wcb.1_Missense_Mutation_p.E199Q|NEXN_uc001dib.3_Missense_Mutation_p.E213Q|NEXN_uc001did.1_Missense_Mutation_p.E187Q|NEXN_uc001dif.1_Missense_Mutation_p.E169Q	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	277	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		TTTAGAAGAAGAGAAGCGTGC	0.363													13	67					0	0	0	0	C	78392542	C	C	78392542	3	2	281	1	0	0	0	0	1	0	0	0	10409	943	33	2	855	2	NEXN	1	78392542	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	7890416	78392542	170858079	5	52383											
DPYD	1806	broad.mit.edu	37	chr1	98039345	98039345	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cactcagaactgaaccaaagGcactgatgaccacatcggct	14	6	8	13	1	1	4	1	3	0	1	2	4	1	4	2	2	2	2	2	2	3	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:98039345G>A	uc001drv.2	-	11	1447	c.1310C>T	c.(1309-1311)GCC>GTC	p.A437V		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	437					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TGAACCAAAGGCACTGATGAC	0.418													18	109					0	0	0	0	A	98039345	A	A	98039345	3	1	281	1	0	0	0	0	1	0	0	0	4767	1203	42	4	1819	4	DPYD	1	98039345	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	19646803	98039345	151211276	6	52384											
CAPZA1	829	broad.mit.edu	37	chr1	113209755	113209758	+	Frame_Shift_Del	DEL	ACTA	-	-																															cataaagatgtacaggattcActaactgtttcggtgagtat																										TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:113209755_113209758delACTA	uc001ecj.1	+	8	1037_1040	c.645_648delACTA	c.(643-648)TCACTAfs	p.S215fs		NM_006135	NP_006126	P52907	CAZA1_HUMAN	F-actin capping protein alpha-1 subunit	215_216					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex|WASH complex	actin binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACAGGATTCACTAACTGTTTCGG	0.368													---	---	---								-	113209758	-	-	113209755	7	5	281	1	0	1	0	1	0	0	0	0	2652	146	6	0	675	0	CAPZA1	1	113209755	Frame_Shift_Del	DEL	ACTA	TCGA-D6-6826-01A-11D-1912-08	15170410	113209755	136040866	7	52385											
LIX1L	128077	broad.mit.edu	37	chr1	145498680	145498680	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgggagctggatgaagccCgactggcaggcaaggagctg	10	4	18	9	2	0	1	0	1	0	0	0	5	0	4	1	5	4	4	1	5	2	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:145498680C>T	uc001enr.2	+	6	990	c.916C>T	c.(916-918)CGA>TGA	p.R306*	NBPF10_uc001emp.3_Intron|LIX1L_uc009wiu.1_5'Flank	NM_153713	NP_714924	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse) like	306										ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGATGAAGCCCGACTGGCAGG	0.587													10	57					0	0	0	0	T	145498680	T	T	145498680	4	4	281	1	0	0	0	0	0	1	0	0	8874	644	23	1	938	1	LIX1L	1	145498680	Nonsense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	32288925	145498680	103751941	8	52386											
FLG	2312	broad.mit.edu	37	chr1	152282437	152282437	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctgcagagtgcccatgaCtggctctatcttcttgatgg	6	14	10	11	0	4	3	0	2	4	1	5	3	4	3	1	2	2	2	1	2	1	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:152282437C>G	uc001ezu.1	-	3	4961	c.4925G>C	c.(4924-4926)AGT>ACT	p.S1642T		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1642	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGCCCATGACTGGCTCTATC	0.557									Ichthyosis				47	323					0	0	0	0	G	152282437	G	G	152282437	3	3	281	1	0	0	0	0	1	0	0	0	5954	565	20	4	7264	4	FLG	1	152282437	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	6783757	152282437	96968184	9	52387											
CREB3L4	148327	broad.mit.edu	37	chr1	153945906	153945906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gacgctaattgctcaaacttCcaacaaagctgcccagacca	14	7	6	14	1	1	1	1	0	0	1	2	2	2	1	3	0	5	3	3	0	4	3	rs146463170		TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:153945906C>T	uc001fdn.3	+	8	1129	c.863C>T	c.(862-864)TCC>TTC	p.S288F	CREB3L4_uc010pef.1_Missense_Mutation_p.S141F|CREB3L4_uc001fdo.3_Missense_Mutation_p.S268F|CREB3L4_uc001fdm.1_Missense_Mutation_p.S288F|CREB3L4_uc001fdp.1_Missense_Mutation_p.S268F|CREB3L4_uc001fdr.2_Missense_Mutation_p.S288F|CREB3L4_uc001fdq.2_Missense_Mutation_p.S268F	NM_130898	NP_570968	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like	288	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCTCAAACTTCCAACAAAGCT	0.522													16	78					0	0	0	0	T	153945906	T	T	153945906	3	4	281	1	0	0	0	0	1	0	0	0	3874	855	30	2	889	2	CREB3L4	1	153945906	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	1663469	153945906	95304715	10	52388											
FCRL2	79368	broad.mit.edu	37	chr1	157737023	157737023	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggtaacacccacccacctGagatggagactggcactgcc	11	5	10	15	0	0	2	0	1	0	2	0	4	0	2	4	3	2	2	4	3	1	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:157737023G>C	uc001fre.2	-	6	1219	c.1160C>G	c.(1159-1161)TCA>TGA	p.S387*	FCRL2_uc001frd.2_Nonsense_Mutation_p.S134*|FCRL2_uc010phz.1_Nonsense_Mutation_p.S387*|FCRL2_uc009wsp.2_Intron	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	387	Ig-like C2-type 4.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCACCCACCTGAGATGGAGAC	0.542													13	71					0	0	0	0	C	157737023	C	C	157737023	4	2	281	1	0	0	0	0	0	1	0	0	5827	1294	45	2	394	2	FCRL2	1	157737023	Nonsense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	3791117	157737023	91513598	11	52389											
MAEL	84944	broad.mit.edu	37	chr1	166991064	166991064	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttacatgtcccaaaaagatgGatacaaatctttctcttcct	13	14	4	10	0	2	1	0	0	2	1	5	2	4	2	2	1	2	0	2	1	5	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:166991064G>C	uc001gdy.1	+	12	1348	c.1277G>C	c.(1276-1278)GGA>GCA	p.G426A	MAEL_uc001gdz.1_Missense_Mutation_p.G395A|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	426					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						CAAAAAGATGGATACAAATCT	0.368													5	47					0	0	0	0	C	166991064	C	C	166991064	3	2	281	1	0	0	0	0	1	0	0	0	9205	1174	41	2	1323	2	MAEL	1	166991064	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	9254041	166991064	82259557	12	52390											
PARP1	142	broad.mit.edu	37	chr1	226564992	226564992	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccacacggccccaggacctGaatatccaatacctgcagtg	11	6	8	16	1	0	1	0	1	0	0	1	2	1	2	6	2	2	1	6	2	4	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:226564992G>C	uc001hqd.3	-	13	1929	c.1758C>G	c.(1756-1758)TTC>TTG	p.F586L		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	586					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		CCCAGGACCTGAATATCCAAT	0.507								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					3	199					0	0	0	0	C	226564992	C	C	226564992	3	2	281	1	0	0	0	0	1	0	0	0	11508	1281	45	2	1330	2	PARP1	1	226564992	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	59573928	226564992	22685629	13	52391											
ACTA1	58	broad.mit.edu	37	chr1	229568585	229568585	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcttgctctgagcctcgtCgcccacgtaggaatctttct	5	14	8	14	3	4	1	0	1	4	0	7	2	4	2	2	1	2	2	2	1	2	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:229568585C>T	uc001htm.2	-	3	277	c.172G>A	c.(172-174)GAC>AAC	p.D58N		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	58					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	TGAGCCTCGTCGCCCACGTAG	0.597													18	78					0	0	0	0	T	229568585	T	T	229568585	3	4	281	1	0	0	0	0	1	0	0	0	191	884	31	1	981	1	ACTA1	1	229568585	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	3003593	229568585	19682036	14	52392											
OR2T6	254879	broad.mit.edu	37	chr1	248551301	248551301	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccatctgcaacccactgcGctatcctgtcctcatcagct	7	10	7	17	1	3	0	2	0	1	0	5	0	5	0	4	1	4	3	4	1	2	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:248551301G>A	uc001iei.1	+	1	392	c.392G>A	c.(391-393)CGC>CAC	p.R131H		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AACCCACTGCGCTATCCTGTC	0.567													34	51					0	0	0	0	A	248551301	A	A	248551301	3	1	281	1	0	0	0	0	1	0	0	0	11083	1087	38	1	394	1	OR2T6	1	248551301	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	18982716	248551301	699320	15	52393											
OR2T34	127068	broad.mit.edu	37	chr1	248738034	248738034	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtgcttgctgtttgattctGagaagtctgattccctgagc	7	15	11	8	0	2	4	0	4	2	1	3	5	3	4	1	0	3	3	1	0	1	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr1:248738034G>C	uc001iep.1	-	1	25	c.25C>G	c.(25-27)CAG>GAG	p.Q9E		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTTTGATTCTGAGAAGTCTGA	0.443													3	60					0	0	0	0	C	248738034	C	C	248738034	3	2	281	1	0	0	0	0	1	0	0	0	11079	1299	45	2	935	2	OR2T34	1	248738034	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	186733	248738034	512587	16	52394											
ANTXR1	84168	broad.mit.edu	37	chr2	69302734	69302734	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttcccaggctaataggtctCgagatcttggtgcaattgtt	8	15	10	8	1	2	1	0	0	2	1	4	2	3	1	1	3	1	3	1	3	3	6			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr2:69302734C>T	uc002sfg.2	+	7	861	c.505C>T	c.(505-507)CGA>TGA	p.R169*	ANTXR1_uc002sfe.2_Nonsense_Mutation_p.R169*|ANTXR1_uc002sff.2_Nonsense_Mutation_p.R169*|ANTXR1_uc002sfd.2_Nonsense_Mutation_p.R169*	NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	169	Extracellular (Potential).|VWFA.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						TAATAGGTCTCGAGATCTTGG	0.418									Familial_Infantile_Hemangioma				20	151					0	0	0	0	T	69302734	T	T	69302734	4	4	281	1	0	0	0	0	0	1	0	0	711	876	31	1	531	1	ANTXR1	2	69302734	Nonsense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08		69302734	173896639	17	52395											
LRP2	4036	broad.mit.edu	37	chr2	170058335	170058335	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtaagagtattggacacatCgcccattggcacaggtgaag	12	8	13	8	1	0	2	0	1	0	1	1	3	0	3	1	4	0	3	1	4	3	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr2:170058335C>T	uc002ues.2	-	44	8468	c.8255G>A	c.(8254-8256)CGA>CAA	p.R2752Q		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2752	Extracellular (Potential).|LDL-receptor class A 17.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTGGACACATCGCCCATTGGC	0.483													9	33					0	0	0	0	T	170058335	T	T	170058335	3	4	281	1	0	0	0	0	1	0	0	0	9006	884	31	1	5856	1	LRP2	2	170058335	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	100755601	170058335	73141038	18	52396											
TTN	7273	broad.mit.edu	37	chr2	179542570	179542570	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacttcctcttcaggaacaaTttcttcttcaaatagaactt	13	15	3	10	0	5	1	2	0	3	1	6	2	6	2	1	1	3	0	1	1	6	7			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr2:179542570T>C	uc010zfg.1	-	143	30561	c.30337A>G	c.(30337-30339)ATT>GTT	p.I10113V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.I6774V|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11040							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGGAACAATTTCTTCTTCA	0.418													16	93					0	0	0	0	C	179542570	C	C	179542570	3	2	281	1	0	0	0	0	1	0	0	0	16803	1493	52	5	70328	5	TTN	2	179542570	Missense_Mutation	SNP	T	TCGA-D6-6826-01A-11D-1912-08	9484235	179542570	63656803	19	52397											
ZDBF2	57683	broad.mit.edu	37	chr2	207171531	207171531	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgacccgcctcttctgtCagttactgagcagtctcatc	6	14	7	14	1	5	2	2	2	4	0	7	2	5	2	2	0	2	2	2	0	1	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr2:207171531C>T	uc002vbp.2	+	5	2529	c.2279C>T	c.(2278-2280)TCA>TTA	p.S760L		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	760							nucleic acid binding|zinc ion binding			ovary(3)	3						CCTCTTCTGTCAGTTACTGAG	0.408													43	158					0	0	0	0	T	207171531	T	T	207171531	3	4	281	1	0	0	0	0	1	0	0	0	17666	838	29	2	2289	2	ZDBF2	2	207171531	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	27628961	207171531	36027842	20	52398											
ABCA12	26154	broad.mit.edu	37	chr2	215914369	215914369	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgggagaactgtttgtttAgttcttggagagaagactct	9	14	12	6	0	2	3	0	0	2	3	2	6	2	4	1	2	1	3	1	2	3	5			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr2:215914369A>G	uc002vew.2	-	6	894	c.674T>C	c.(673-675)CTA>CCA	p.L225P	ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	225					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTGTTTGTTTAGTTCTTGGAG	0.388													7	36					0	0	0	0	G	215914369	G	G	215914369	3	3	281	1	0	0	0	0	1	0	0	0	30	420	15	5	7336	5	ABCA12	2	215914369	Missense_Mutation	SNP	A	TCGA-D6-6826-01A-11D-1912-08	8742838	215914369	27285004	21	52399											
MON1A	84315	broad.mit.edu	37	chr3	49947692	49947692	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cgcttgcgaaggcgctcctgGaagcggcggcggcagtcaga	7	5	17	12	6	1	1	1	0	0	1	2	3	2	2	1	5	2	3	1	5	2	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr3:49947692G>A	uc003cxz.2	-	4	1656	c.1530C>T	c.(1528-1530)TTC>TTT	p.F510F	MON1A_uc003cya.2_Silent_p.F348F|MON1A_uc003cyb.2_Silent_p.F348F	NM_032355	NP_115731	Q86VX9	MON1A_HUMAN	MON1 homolog A isoform a	413							protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GGCGCTCCTGGAAGCGGCGGC	0.627													13	39					0	0	0	0	A	49947692	A	A	49947692	2	1	281	1	0	0	0	0	0	0	0	1	9751	1165	41	2		2	MON1A	3	49947692	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08		49947692	148074738	22	52400											
KIAA1524	57650	broad.mit.edu	37	chr3	108271206	108271206	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttttcttcttgtacttttgTtttttgatgcaaatcttaaa	8	23	4	6	0	3	1	0	1	3	0	3	1	3	1	0	0	2	3	0	0	4	11			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr3:108271206T>A	uc003dxb.3	-	20	2691	c.2422A>T	c.(2422-2424)ACA>TCA	p.T808S		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	808	Potential.					cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						TGTACTTTTGTTTTTTGATGC	0.313													4	13					0	0	0	0	A	108271206	A	A	108271206	3	1	281	1	0	0	0	0	1	0	0	0	8278	1725	60	5	303	5	KIAA1524	3	108271206	Missense_Mutation	SNP	T	TCGA-D6-6826-01A-11D-1912-08	58323514	108271206	89751224	23	52401											
ABCC5	10057	broad.mit.edu	37	chr3	183695333	183695333	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaacagccactgaggctTctgagagggactttactgaa	11	10	11	9	0	2	3	1	3	1	1	2	5	2	4	1	2	3	1	1	2	3	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr3:183695333T>C	uc003fmg.2	-	10	1541	c.1376A>G	c.(1375-1377)GAA>GGA	p.E459G	ABCC5_uc011bqt.1_5'UTR|ABCC5_uc010hxl.2_Missense_Mutation_p.E459G	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	459	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CACTGAGGCTTCTGAGAGGGA	0.488													13	27					0	0	0	0	C	183695333	C	C	183695333	3	2	281	1	0	0	0	0	1	0	0	0	56	1783	62	5	3021	5	ABCC5	3	183695333	Missense_Mutation	SNP	T	TCGA-D6-6826-01A-11D-1912-08	75424127	183695333	14327097	24	52402											
GP5	2814	broad.mit.edu	37	chr3	194118222	194118222	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagagtcagattgtgcgaatGaagaaagagcgcagagggga	15	5	16	5	2	1	6	1	1	0	5	1	8	1	7	0	2	2	1	0	2	3	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr3:194118222G>A	uc003ftv.1	-	2	821	c.790C>T	c.(790-792)CAT>TAT	p.H264Y		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	264	Extracellular (Potential).|LRR 8.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		TTGTGCGAATGAAGAAAGAGC	0.602													13	70					0	0	0	0	A	194118222	A	A	194118222	3	1	281	1	0	0	0	0	1	0	0	0	6621	1290	45	2	896	2	GP5	3	194118222	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	10422889	194118222	3904208	25	52403											
SLC4A4	8671	broad.mit.edu	37	chr4	72121007	72121007	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagacgtcacaagagaaaGacagggcacaaagaaaagaa	22	1	12	6	1	1	5	1	0	0	5	1	7	1	5	0	2	0	1	0	2	6	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr4:72121007G>T	uc003hfy.2	+	3	261	c.144G>T	c.(142-144)AAG>AAT	p.K48N	SLC4A4_uc010iic.2_Missense_Mutation_p.K48N|SLC4A4_uc010iib.2_Missense_Mutation_p.K48N|SLC4A4_uc003hfz.2_Missense_Mutation_p.K48N|SLC4A4_uc003hga.2_5'UTR	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	48	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			ACAAGAGAAAGACAGGGCACA	0.438													38	119					1.30998e-17	2.562e-17	1	0	T	72121007	T	T	72121007	3	4	281	1	0	0	0	0	1	0	0	0	14720	933	33	2	150	2	SLC4A4	4	72121007	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08		72121007	119033269	26	52404											
ART3	419	broad.mit.edu	37	chr4	77003501	77003501	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggctgctaatgaccagctCactgtgttatccatctacac	10	11	7	13	0	2	1	1	1	1	0	3	1	3	1	2	1	3	4	2	1	3	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr4:77003501C>T	uc003hjo.2	+	3	713	c.594C>T	c.(592-594)CTC>CTT	p.L198L	ART3_uc003hji.2_Silent_p.L198L|ART3_uc003hjj.2_Silent_p.L198L|ART3_uc003hjk.2_Silent_p.L198L|ART3_uc010ija.1_Silent_p.L198L|ART3_uc003hjn.2_Silent_p.L198L|ART3_uc003hjp.2_Intron|ART3_uc010ijb.2_Intron|ART3_uc003hjq.2_Intron|ART3_uc003hjr.2_Silent_p.L168L|ART3_uc010ijc.2_Silent_p.L168L|ART3_uc010ijd.2_Silent_p.L168L	NM_001130016	NP_001123488	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3 isoform a	198					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			ovary(2)	2			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ATGACCAGCTCACTGTGTTAT	0.408													13	38					0	0	0	0	T	77003501	T	T	77003501	2	4	281	1	0	0	0	0	0	0	0	1	1000	813	29	2		2	ART3	4	77003501	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08	4882494	77003501	114150775	27	52405											
UNC5C	8633	broad.mit.edu	37	chr4	96222864	96222864	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagttcttccacttgctggCgcgaaatctcaatgctcact	9	12	8	12	2	3	1	2	0	2	1	5	2	4	1	1	1	2	3	1	1	2	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr4:96222864C>T	uc003htp.1	-	3	537	c.383G>A	c.(382-384)CGC>CAC	p.R128H	UNC5C_uc010ilc.1_Missense_Mutation_p.R128H|UNC5C_uc003htq.2_Missense_Mutation_p.R128H	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	128	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CACTTGCTGGCGCGAAATCTC	0.473													13	28					0	0	0	0	T	96222864	T	T	96222864	3	4	281	1	0	0	0	0	1	0	0	0	17061	768	27	1	2468	1	UNC5C	4	96222864	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	19219363	96222864	94931412	28	52406											
ALPK1	80216	broad.mit.edu	37	chr4	113352354	113352354	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catttcgagtctccttggatCaagatgtggagactgagact	10	12	11	8	1	2	3	1	1	1	3	4	7	2	4	1	2	0	0	1	2	1	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr4:113352354C>T	uc003iap.3	+	11	1930	c.1651C>T	c.(1651-1653)CAA>TAA	p.Q551*	ALPK1_uc003ian.3_Nonsense_Mutation_p.Q551*|ALPK1_uc011cfx.1_Nonsense_Mutation_p.Q473*|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Nonsense_Mutation_p.Q379*	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	551							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		CTCCTTGGATCAAGATGTGGA	0.493													9	69					0	0	0	0	T	113352354	T	T	113352354	4	4	281	1	0	0	0	0	0	1	0	0	544	827	29	2	1685	2	ALPK1	4	113352354	Nonsense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	17129490	113352354	77801922	29	52407											
ZNF827	152485	broad.mit.edu	37	chr4	146807275	146807275	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaaagggcacagctggcaCtgaaaggtctctccccgatc	11	7	11	12	1	1	1	0	1	1	0	4	2	2	1	2	3	1	4	2	3	3	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr4:146807275C>A	uc003ikn.2	-	4	1350	c.1302G>T	c.(1300-1302)CAG>CAT	p.Q434H	ZNF827_uc003ikm.2_Missense_Mutation_p.Q434H|ZNF827_uc010iox.2_Missense_Mutation_p.Q84H	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	434	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					ACAGCTGGCACTGAAAGGTCT	0.522													7	16					8.12818e-05	0.000142566	1	0	A	146807275	A	A	146807275	3	1	281	1	0	0	0	0	1	0	0	0	18247	564	20	4	1971	4	ZNF827	4	146807275	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	33454921	146807275	44347001	30	52408											
DCHS2	54798	broad.mit.edu	37	chr4	155157872	155157872	+	Silent	SNP	T	A	A																															atgacagctgtggaactcaaTggagggcagccactgtcaga																										TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr4:155157872T>A	uc003inw.2	-	25	6567	c.6567A>T	c.(6565-6567)CCA>CCT	p.P2189P		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2189	Cadherin 19.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGAACTCAATGGAGGGCAGC	0.468													12	31					0	0	0	0	A	155157872	A	A	155157872	2	1	281	1	0	0	0	0	0	0	0	1	4305	1451	51	5		5	DCHS2	4	155157872	Silent	SNP	T	TCGA-D6-6826-01A-11D-1912-08	8350597	155157872	35996404	31	52409	119	2									
DCHS2	54798	broad.mit.edu	37	chr4	155157874	155157874	+	Missense_Mutation	SNP	G	A	A																															gacagctgtggaactcaatgGagggcagccactgtcagatg																										TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr4:155157874G>A	uc003inw.2	-	25	6565	c.6565C>T	c.(6565-6567)CCA>TCA	p.P2189S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2189	Cadherin 19.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAACTCAATGGAGGGCAGCCA	0.463													13	29					0	0	0	0	A	155157874	A	A	155157874	3	1	281	1	0	0	0	0	1	0	0	0	4305	1174	41	2	2189	2	DCHS2	4	155157874	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	2	155157874	35996402	32	52410	119	2									
FSTL5	56884	broad.mit.edu	37	chr4	162307346	162307346	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtagtggccatctggagaGacatatggagtgcccgtcac	10	8	14	9	1	2	1	1	0	1	1	2	4	2	3	2	4	1	1	2	4	2	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr4:162307346G>A	uc003iqh.2	-	16	2533	c.2097C>T	c.(2095-2097)GTC>GTT	p.V699V	FSTL5_uc003iqi.2_Silent_p.V698V|FSTL5_uc010iqv.2_Silent_p.V689V|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	699						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CATCTGGAGAGACATATGGAG	0.473													13	66					0	0	0	0	A	162307346	A	A	162307346	2	1	281	1	0	0	0	0	0	0	0	1	6114	929	33	2		2	FSTL5	4	162307346	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08	7149472	162307346	28846930	33	52411											
ANP32C	23520	broad.mit.edu	37	chr4	165118599	165118599	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttgttgccacttaaatataGatgcgtgaggtttggacact	10	15	10	6	1	0	2	0	1	0	1	0	3	0	3	1	2	2	2	1	2	4	6			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr4:165118599G>C	uc011cjk.1	-	1	265	c.265C>G	c.(265-267)CTA>GTA	p.L89V	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	89	LRR 3.										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		CTTAAATATAGATGCGTGAGG	0.408													27	133					0	0	0	0	C	165118599	C	C	165118599	3	2	281	1	0	0	0	0	1	0	0	0	707	933	33	2	442	2	ANP32C	4	165118599	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	2811253	165118599	26035677	34	52412											
DDX60	55601	broad.mit.edu	37	chr4	169215016	169215016	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacattctcaaagataatgaGcatgaagtaacacaaaagac	20	8	6	7	0	1	4	1	2	1	2	2	4	1	4	0	0	3	2	0	0	7	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr4:169215016G>A	uc003irp.2	-	7	1096	c.804C>T	c.(802-804)TGC>TGT	p.C268C		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	268							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AAGATAATGAGCATGAAGTAA	0.413													14	78					0	0	0	0	A	169215016	A	A	169215016	2	1	281	1	0	0	0	0	0	0	0	1	4395	963	34	4		4	DDX60	4	169215016	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08	4096417	169215016	21939260	35	52413											
TRIP13	9319	broad.mit.edu	37	chr5	908529	908529	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaccgagccatcagatgcCatccgcgtggtcaatgctgt	8	8	12	13	3	2	1	2	0	0	1	3	2	3	1	4	2	3	2	4	2	1	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr5:908529C>T	uc003jbr.2	+	9	929	c.819C>T	c.(817-819)GCC>GCT	p.A273A	TRIP13_uc010ite.1_Silent_p.A273A	NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	273					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			CATCAGATGCCATCCGCGTGG	0.542													13	73					0	0	0	0	T	908529	T	T	908529	2	4	281	1	0	0	0	0	0	0	0	1	16624	581	21	4		4	TRIP13	5	908529	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08		908529	180006731	36	52414											
PRKAA1	5562	broad.mit.edu	37	chr5	40798208	40798208	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccccagcgtgtcacccagAatgtagtggccgatcttcac	9	8	9	15	2	3	1	2	0	1	1	3	2	3	1	4	1	1	1	4	1	2	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr5:40798208A>G	uc003jmc.2	-	1	90	c.84T>C	c.(82-84)ATT>ATC	p.I28I	PRKAA1_uc003jmb.2_Silent_p.I28I	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	28	Protein kinase.				activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	TGTCACCCAGAATGTAGTGGC	0.602													8	32					0	0	0	0	G	40798208	G	G	40798208	2	3	281	1	0	0	0	0	0	0	0	1	12555	242	9	5		5	PRKAA1	5	40798208	Silent	SNP	A	TCGA-D6-6826-01A-11D-1912-08	39889679	40798208	140117052	37	52415											
BHMT2	23743	broad.mit.edu	37	chr5	78379594	78379594	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagaggagctggccccagaaAggggctttttgccaccagct	9	7	13	12	0	0	2	0	0	0	2	0	3	0	3	4	4	3	3	4	4	1	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr5:78379594A>G	uc003kft.2	+	7	948	c.925A>G	c.(925-927)AGG>GGG	p.R309G	BHMT2_uc011cth.1_Missense_Mutation_p.R245G	NM_017614	NP_060084	Q9H2M3	BHMT2_HUMAN	betaine-homocysteine methyltransferase 2	309					methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			ovary(1)	1		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	GGCCCCAGAAAGGGGCTTTTT	0.537													6	32					0	0	0	0	G	78379594	G	G	78379594	3	3	281	1	0	0	0	0	1	0	0	0	1429	63	3	5	951	5	BHMT2	5	78379594	Missense_Mutation	SNP	A	TCGA-D6-6826-01A-11D-1912-08	37581386	78379594	102535666	38	52416											
CMYA5	202333	broad.mit.edu	37	chr5	79028659	79028659	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcaacaactacagcatcTgtaactaagcttgattcaaa	15	11	4	11	0	3	1	2	1	1	0	4	1	4	1	1	0	6	3	1	0	6	5			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr5:79028659T>C	uc003kgc.2	+	2	4143	c.4071T>C	c.(4069-4071)TCT>TCC	p.S1357S		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1357						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CTACAGCATCTGTAACTAAGC	0.373													9	33					0	0	0	0	C	79028659	C	C	79028659	2	2	281	1	0	0	0	0	0	0	0	1	3605	1567	55	5		5	CMYA5	5	79028659	Silent	SNP	T	TCGA-D6-6826-01A-11D-1912-08	649065	79028659	101886601	39	52417											
PAM	5066	broad.mit.edu	37	chr5	102342680	102342680	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcaggattgtgcagttttCaccaagtggaaagttcatca	12	11	10	8	0	3	0	3	0	0	0	3	2	3	2	1	2	2	4	1	2	2	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr5:102342680C>T	uc003knw.2	+	18	2352	c.1979C>T	c.(1978-1980)TCA>TTA	p.S660L	PAM_uc003kns.2_Missense_Mutation_p.S553L|PAM_uc003knt.2_Missense_Mutation_p.S660L|PAM_uc003knu.2_Missense_Mutation_p.S660L|PAM_uc003knv.2_Missense_Mutation_p.S660L|PAM_uc011cuz.1_Missense_Mutation_p.S563L|PAM_uc003knz.2_5'Flank	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	660	Peptidyl-alpha-hydroxyglycine alpha- amidating lyase (By similarity).|NHL 3.|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	GTGCAGTTTTCACCAAGTGGA	0.438													13	66					0	0	0	0	T	102342680	T	T	102342680	3	4	281	1	0	0	0	0	1	0	0	0	11466	838	29	2	2049	2	PAM	5	102342680	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	23314021	102342680	78572580	40	52418											
PCDHGC5	56097	broad.mit.edu	37	chr5	140871168	140871168	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcggacggcagtgacttCacttttctaagacccctcag	8	10	9	14	2	3	2	2	1	1	1	4	3	3	3	3	2	0	1	3	2	1	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr5:140871168C>A	uc003lla.1	+	1	2361	c.2361C>A	c.(2359-2361)TTC>TTA	p.F787L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc003lky.1_Intron|PCDHGC5_uc011dbc.1_Missense_Mutation_p.F787L	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	787	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGTGACTTCACTTTTCTAA	0.632													9	45					3.07112e-06	5.51802e-06	1	0	A	140871168	A	A	140871168	3	1	281	1	0	0	0	0	1	0	0	0	11625	825	29	2	2363	2	PCDHGC5	5	140871168	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	38528488	140871168	40044092	41	52419											
HAND1	9421	broad.mit.edu	37	chr5	153855399	153855399	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccagcgcccagacttgctgCggccagccggtgcgtccttt	4	9	12	16	4	0	1	0	0	0	1	2	1	2	1	5	2	5	1	5	2	0	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr5:153855399C>T	uc003lvn.2	-	2	871	c.615G>A	c.(613-615)CCG>CCA	p.P205P		NM_004821	NP_004812	O96004	HAND1_HUMAN	basic helix-loop-helix transcription factor	205					angiogenesis|cardiac left ventricle formation|cardiac right ventricle formation|cardiac septum morphogenesis|heart looping|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|trophectodermal cell differentiation|ventricular cardiac muscle tissue morphogenesis	cytoplasm|nucleolus|nucleoplasm	bHLH transcription factor binding|DNA binding|protein homodimerization activity|transcription coactivator activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			AGACTTGCTGCGGCCAGCCGG	0.632													8	31					0	0	0	0	T	153855399	T	T	153855399	2	4	281	1	0	0	0	0	0	0	0	1	6988	755	27	1		1	HAND1	5	153855399	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08	12984231	153855399	27059861	42	52420											
BTN1A1	696	broad.mit.edu	37	chr6	26509261	26509261	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaattgctgatgggcctgaGagggtcacagtcattgctaa	10	10	12	9	0	2	2	2	2	0	1	2	3	2	2	2	2	2	2	2	2	2	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr6:26509261G>C	uc003nif.3	+	7	1460	c.1440G>C	c.(1438-1440)GAG>GAC	p.E480D		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	480	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						ATGGGCCTGAGAGGGTCACAG	0.552													14	54					0	0	0	0	C	26509261	C	C	26509261	3	2	281	1	0	0	0	0	1	0	0	0	1564	933	33	2	1466	2	BTN1A1	6	26509261	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08		26509261	144605806	43	52421											
DDR1	780	broad.mit.edu	37	chr6	30866738	30866738	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgctgatgctctgtagggCccagccctttgggcagctca	5	10	14	12	0	2	1	1	1	1	0	2	1	2	1	2	3	4	5	2	3	1	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr6:30866738C>T	uc003nrr.2	+	18	2784	c.2525C>T	c.(2524-2526)GCC>GTC	p.A842V	DDR1_uc010jse.2_Missense_Mutation_p.A805V|DDR1_uc003nrq.2_Missense_Mutation_p.A805V|DDR1_uc003nrs.2_Missense_Mutation_p.A842V|DDR1_uc003nrt.2_Missense_Mutation_p.A805V|DDR1_uc011dms.1_Missense_Mutation_p.A823V|DDR1_uc003nru.2_Missense_Mutation_p.A805V|DDR1_uc003nrv.2_Missense_Mutation_p.A848V|DDR1_uc003nrz.1_Missense_Mutation_p.A167V	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	842	Cytoplasmic (Potential).|Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	CTCTGTAGGGCCCAGCCCTTT	0.617													19	69					0	0	0	0	T	30866738	T	T	30866738	3	4	281	1	0	0	0	0	1	0	0	0	4353	739	26	4	2605	4	DDR1	6	30866738	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	4357477	30866738	140248329	44	52422											
CRISP3	10321	broad.mit.edu	37	chr6	49703279	49703279	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtttgcccacttttgggcaTttgctgcagcctctttgttc	3	17	10	11	0	1	0	0	0	1	0	2	0	1	0	2	2	4	5	2	2	0	6			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr6:49703279T>C	uc003ozs.2	-	4	230	c.215A>G	c.(214-216)AAT>AGT	p.N72S		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	72					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTTTTGGGCATTTGCTGCAGC	0.368													21	97					0	0	0	0	C	49703279	C	C	49703279	3	2	281	1	0	0	0	0	1	0	0	0	3896	1493	52	5	542	5	CRISP3	6	49703279	Missense_Mutation	SNP	T	TCGA-D6-6826-01A-11D-1912-08	18836541	49703279	121411788	45	52423											
TBX18	9096	broad.mit.edu	37	chr6	85472362	85472362	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggggcctgcggcgagggcaGaggggtcccgggccgggcca	4	2	22	13	5	0	1	0	0	0	1	1	2	1	1	4	8	1	1	4	8	0	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr6:85472362G>C	uc003pkl.1	-	2	397	c.397C>G	c.(397-399)CTG>GTG	p.L133V	TBX18_uc010kbq.1_5'UTR	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	133					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GGCGAGGGCAGAGGGGTCCCG	0.697													10	57					0	0	0	0	C	85472362	C	C	85472362	3	2	281	1	0	0	0	0	1	0	0	0	15719	933	33	2	1454	2	TBX18	6	85472362	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	35769083	85472362	85642705	46	52424											
RNF216	54476	broad.mit.edu	37	chr7	5780720	5780720	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggaaaggctggacctggctCttcatcatcacttgctaact	9	12	9	11	0	4	0	3	0	1	0	4	2	4	2	1	4	2	3	1	4	2	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr7:5780720C>G	uc003soy.1	-	4	947	c.757G>C	c.(757-759)GAG>CAG	p.E253Q	RNF216_uc010ksz.1_5'UTR|RNF216_uc010kta.1_Intron|RNF216_uc011jwj.1_Intron|RNF216_uc003sox.1_Missense_Mutation_p.E310Q	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	253					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		GGACCTGGCTCTTCATCATCA	0.517													10	94					0	0	0	0	G	5780720	G	G	5780720	3	3	281	1	0	0	0	0	1	0	0	0	13545	922	32	2	1899	2	RNF216	7	5780720	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08		5780720	153357943	47	52425											
THSD7A	221981	broad.mit.edu	37	chr7	11514030	11514030	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtctgcatgccgacagagCaggaggcctccccattccaa	9	8	10	14	1	1	1	0	0	1	1	3	3	3	2	5	2	3	2	5	2	1	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr7:11514030C>A	uc003ssf.3	-	8	2435	c.2183G>T	c.(2182-2184)TGC>TTC	p.C728F		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	728	TSP type-1 7.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GCCGACAGAGCAGGAGGCCTC	0.507										HNSCC(18;0.044)			16	67					0.000566183	0.000962511	1	0	A	11514030	A	A	11514030	3	1	281	1	0	0	0	0	1	0	0	0	15945	710	25	4	2870	4	THSD7A	7	11514030	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	5733310	11514030	147624633	48	52426											
CPVL	54504	broad.mit.edu	37	chr7	29035453	29035453	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatcatgtcaaaagctctcaGaggctggtcatagggtaaaa	15	9	10	7	0	4	1	4	0	1	1	5	1	4	1	0	3	1	3	0	3	6	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr7:29035453G>C	uc003szv.2	-	13	1485	c.1366C>G	c.(1366-1368)CTG>GTG	p.L456V	CPVL_uc003szw.2_Missense_Mutation_p.L456V|CPVL_uc003szx.2_Missense_Mutation_p.L456V	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	456					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						AAAGCTCTCAGAGGCTGGTCA	0.343													4	35					0	0	0	0	C	29035453	C	C	29035453	3	2	281	1	0	0	0	0	1	0	0	0	3850	933	33	2	68	2	CPVL	7	29035453	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	17521423	29035453	130103210	49	52427											
INMT	11185	broad.mit.edu	37	chr7	30791838	30791838	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agggactacttggctacttaCtacagcttcgatggcagccc	9	10	10	12	1	0	0	0	0	0	0	1	2	0	1	1	3	6	3	1	3	4	6			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr7:30791838C>T	uc003tbs.1	+	1	88	c.72C>T	c.(70-72)TAC>TAT	p.Y24Y	FAM188B_uc010kwe.2_5'UTR|INMT_uc010kwc.1_Intron|INMT_uc010kwd.1_Silent_p.Y24Y	NM_006774	NP_006765	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	24						cytoplasm	amine N-methyltransferase activity				0						TGGCTACTTACTACAGCTTCG	0.577													52	101					0	0	0	0	T	30791838	T	T	30791838	2	4	281	1	0	0	0	0	0	0	0	1	7784	576	20	4		4	INMT	7	30791838	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08	1756385	30791838	128346825	50	52428											
FKBP9	11328	broad.mit.edu	37	chr7	33028259	33028259	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctggggtatggagaggaagGaagaggtgagcatcagcatc	12	6	17	6	0	1	3	1	1	0	2	2	6	1	5	1	6	2	3	1	6	3	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr7:33028259G>T	uc003tdh.2	+	6	1215	c.1034G>T	c.(1033-1035)GGA>GTA	p.G345V	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Missense_Mutation_p.G398V|FKBP9_uc011kam.1_Missense_Mutation_p.G113V|FKBP9_uc003tdg.2_Missense_Mutation_p.G345V	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	345	PPIase FKBP-type 3.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			GGAGAGGAAGGAAGAGGTGAG	0.463													10	54					1.76689e-08	3.30918e-08	1	0	T	33028259	T	T	33028259	3	4	281	1	0	0	0	0	1	0	0	0	5947	1174	41	2	1056	2	FKBP9	7	33028259	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	2236421	33028259	126110404	51	52429											
ZP3	7784	broad.mit.edu	37	chr7	76062842	76062842	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cacctgggagatgcagcccaCctccaggcagaaatccacac	12	4	9	16	0	0	2	0	0	0	2	2	3	2	2	5	2	2	2	5	2	1	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr7:76062842C>G	uc003ufd.3	+	4	601	c.591C>G	c.(589-591)CAC>CAG	p.H197Q	ZP3_uc003ufc.3_Missense_Mutation_p.H146Q|ZP3_uc003ufe.2_Missense_Mutation_p.H105Q	NM_001110354	NP_001103824	P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 isoform 1	197	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding				0						ATGCAGCCCACCTCCAGGCAG	0.502													14	109					0	0	0	0	G	76062842	G	G	76062842	3	3	281	1	0	0	0	0	1	0	0	0	18284	506	18	4	605	4	ZP3	7	76062842	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	43034583	76062842	83075821	52	52430											
ABCB4	5244	broad.mit.edu	37	chr7	87035604	87035604	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagctactctttaacttacGtggggtaacgtctcgatgaa	10	13	9	9	3	3	1	1	1	2	0	4	2	3	1	0	2	5	2	0	2	5	5			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr7:87035604G>A	uc003uiv.1	-	26	3583	c.3507C>T	c.(3505-3507)CAC>CAT	p.H1169H	ABCB4_uc003uiw.1_Silent_p.H1162H|ABCB4_uc003uix.1_Silent_p.H1115H	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	1169	ABC transporter 2.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTTAACTTACGTGGGGTAACG	0.393													19	175					0	0	0	0	A	87035604	A	A	87035604	2	1	281	1	0	0	0	0	0	0	0	1	43	1159	40	1		1	ABCB4	7	87035604	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08	10972762	87035604	72103059	53	52431											
SSPO	23145	broad.mit.edu	37	chr7	149489170	149489170	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagagccttgccctcaggaCggctgccccaatgccacttg	7	8	10	16	1	2	1	2	0	0	1	2	2	2	2	5	2	4	1	5	2	1	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr7:149489170C>T	uc010lpk.2	+	37	5415	c.5415C>T	c.(5413-5415)GAC>GAT	p.D1805D		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1805	TSP type-1 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCCTCAGGACGGCTGCCCCA	0.632													11	56					0	0	0	0	T	149489170	T	T	149489170	2	4	281	1	0	0	0	0	0	0	0	1	15255	535	19	1		1	SSPO	7	149489170	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08	62453566	149489170	9649493	54	52432											
HNF4G	3174	broad.mit.edu	37	chr8	76476246	76476246	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	actcccttccccaccacaagGctctgggcaagaacagtaca	12	6	7	16	0	1	1	0	0	1	1	3	1	3	1	4	2	2	3	4	2	4	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr8:76476246G>T	uc003yaq.2	+	11	1412	c.1142G>T	c.(1141-1143)GGC>GTC	p.G381V	HNF4G_uc003yar.2_Missense_Mutation_p.G418V	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	381					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.G381D(1)		ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			CCACCACAAGGCTCTGGGCAA	0.448													21	138					1.96292e-10	3.73971e-10	1	0	T	76476246	T	T	76476246	3	4	281	1	0	0	0	0	1	0	0	0	7293	1203	42	4	1291	4	HNF4G	8	76476246	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08		76476246	69887776	55	52433											
PDP1	54704	broad.mit.edu	37	chr8	94934378	94934378	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgttactgccaccacaaaCatctctgttgttcctcatcg	9	13	5	14	1	2	0	1	0	1	0	5	0	3	0	3	0	3	3	3	0	2	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr8:94934378C>T	uc003yge.2	+	2	360	c.91C>T	c.(91-93)CAT>TAT	p.H31Y	PDP1_uc003ygf.2_Missense_Mutation_p.H56Y|PDP1_uc010max.2_Missense_Mutation_p.H56Y|PDP1_uc011lgm.1_Missense_Mutation_p.H31Y|PDP1_uc011lgn.1_Missense_Mutation_p.H90Y	NM_018444	NP_060914	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic	31					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						CCACCACAAACATCTCTGTTG	0.483													10	100					0	0	0	0	T	94934378	T	T	94934378	3	4	281	1	0	0	0	0	1	0	0	0	11739	478	17	4	274	4	PDP1	8	94934378	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	18458132	94934378	51429644	56	52434											
ASAP1	50807	broad.mit.edu	37	chr8	131127878	131127878	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cataatttacactcactttgTcatccagatcatcatcgctc	11	14	3	13	1	4	1	4	0	0	1	7	1	5	1	1	0	1	1	1	0	2	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr8:131127878T>A	uc003yta.1	-	22	2196	c.2168A>T	c.(2167-2169)GAC>GTC	p.D723V	ASAP1_uc003ysz.1_Missense_Mutation_p.D534V|ASAP1_uc011liw.1_Missense_Mutation_p.D716V	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	723					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						ACTCACTTTGTCATCCAGATC	0.413													71	233					0	0	0	0	A	131127878	A	A	131127878	3	1	281	1	0	0	0	0	1	0	0	0	1012	1667	58	5	1253	5	ASAP1	8	131127878	Missense_Mutation	SNP	T	TCGA-D6-6826-01A-11D-1912-08	36193500	131127878	15236144	57	52435											
FAM135B	51059	broad.mit.edu	37	chr8	139165105	139165105	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctctggacctggactccttCtagaagtatccacatctgcc	8	11	7	15	0	3	1	0	0	3	1	5	3	5	3	5	2	1	1	5	2	3	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr8:139165105C>T	uc003yuy.2	-	13	1784	c.1613G>A	c.(1612-1614)AGA>AAA	p.R538K	FAM135B_uc003yux.2_Missense_Mutation_p.R439K|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.R100K|FAM135B_uc003yvb.2_Missense_Mutation_p.R100K	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	538										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGGACTCCTTCTAGAAGTATC	0.502										HNSCC(54;0.14)			8	91					0	0	0	0	T	139165105	T	T	139165105	3	4	281	1	0	0	0	0	1	0	0	0	5477	913	32	2	2639	2	FAM135B	8	139165105	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	8037227	139165105	7198917	58	52436											
IFNA14	3448	broad.mit.edu	37	chr9	21239989	21239989	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggggtaacactgaaccttGggttgtaggttttctgaaga	10	12	14	5	0	1	3	0	2	1	1	1	4	1	3	1	4	2	4	1	4	4	6			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr9:21239989G>A	uc010mis.2	-						IFNA14_uc003zoo.1_RNA	NM_002172	NP_002163	P01570	IFN14_HUMAN	interferon, alpha 14 precursor						blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		ACTGAACCTTGGGTTGTAGGT	0.453													3	35					0	0	0	0	A	21239989	A	A	21239989	1	1	281	0	1	0	0	0	0	0	0	0	7573	1363	47	4		4	IFNA14	9	21239989	5'Flank	SNP	G	TCGA-D6-6826-01A-11D-1912-08		21239989	119973442	59	52437											
KIAA0368	23392	broad.mit.edu	37	chr9	114184479	114184479	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtgaataaatgtggcatccGactgcaaaagaatgtaaaaa	19	8	9	5	1	0	2	0	1	0	1	1	3	1	2	1	1	1	3	1	1	9	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr9:114184479G>A	uc004bfe.1	-	15	1801	c.1801C>T	c.(1801-1803)CGG>TGG	p.R601W	KIAA0368_uc010muc.1_Missense_Mutation_p.R423W	NM_001080398	NP_001073867			KIAA0368 protein												0						TGTGGCATCCGACTGCAAAAG	0.353													14	56					0	0	0	0	A	114184479	A	A	114184479	3	1	281	1	0	0	0	0	1	0	0	0	8210	1072	37	1	4400	1	KIAA0368	9	114184479	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	92944490	114184479	27028952	60	52438											
GBF1	8729	broad.mit.edu	37	chr10	104128578	104128578	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctctatgcaaattcacagctCtcagcagtgaggtgagcagg	11	9	11	10	0	3	2	2	2	2	0	4	2	3	2	0	2	4	4	0	2	2	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr10:104128578C>G	uc001kux.1	+	23	3199	c.2959C>G	c.(2959-2961)CTC>GTC	p.L987V	GBF1_uc001kuy.1_Missense_Mutation_p.L987V|GBF1_uc001kuz.1_Missense_Mutation_p.L988V	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	987					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		ATTCACAGCTCTCAGCAGTGA	0.502													14	83					0	0	0	0	G	104128578	G	G	104128578	3	3	281	1	0	0	0	0	1	0	0	0	6306	913	32	2	3045	2	GBF1	10	104128578	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08		104128578	31406169	61	52439											
TDRD1	56165	broad.mit.edu	37	chr10	115987042	115987042	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacatcacacctcaaaggcaGagtgctttaaatacaggtat	16	9	7	9	0	2	1	2	0	0	1	2	1	2	1	1	2	3	3	1	2	6	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr10:115987042G>C	uc001lbg.1	+	23	3540	c.3387G>C	c.(3385-3387)CAG>CAC	p.Q1129H	TDRD1_uc001lbf.2_Missense_Mutation_p.Q1006H|TDRD1_uc001lbh.1_Missense_Mutation_p.Q1116H|TDRD1_uc001lbi.1_Missense_Mutation_p.Q1120H|TDRD1_uc010qsc.1_Intron|TDRD1_uc001lbj.2_Missense_Mutation_p.Q838H	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	1129					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		CTCAAAGGCAGAGTGCTTTAA	0.358													10	42					0	0	0	0	C	115987042	C	C	115987042	3	2	281	1	0	0	0	0	1	0	0	0	15796	933	33	2	3473	2	TDRD1	10	115987042	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	11858464	115987042	19547705	62	52440											
MUC2	4583	broad.mit.edu	37	chr11	1078277	1078277	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatccccaggcgtgctcttCagtcccctggagtttgggaa	6	10	12	13	1	2	0	1	0	1	0	4	2	4	2	4	3	1	3	4	3	1	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr11:1078277C>G	uc001lsx.1	+	5	591	c.564C>G	c.(562-564)TTC>TTG	p.F188L		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	188	VWFD 1.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GCGTGCTCTTCAGTCCCCTGG	0.662													10	53					0	0	0	0	G	1078277	G	G	1078277	3	3	281	1	0	0	0	0	1	0	0	0	10028	825	29	2	582	2	MUC2	11	1078277	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08		1078277	133928239	63	52441											
HBB	3043	broad.mit.edu	37	chr11	5248168	5248168	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttgataccaacctgcccagGgcctcaccaccaacttcatc	10	8	5	18	0	2	1	2	1	0	0	3	1	2	1	6	1	4	0	6	1	3	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr11:5248168G>A	uc001mae.1	-	1	134	c.84C>T	c.(82-84)GCC>GCT	p.A28A		NM_000518	NP_000509	P68871	HBB_HUMAN	beta globin	28			A -> S (in Knossos).|A -> D (in Volga/Drenthe; unstable).|A -> V (in Grange-blanche; O(2) affinity up).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	ACCTGCCCAGGGCCTCACCAC	0.512									Sickle_Cell_Trait				11	36					0	0	0	0	A	5248168	A	A	5248168	2	1	281	1	0	0	0	0	0	0	0	1	7017	1219	43	4		4	HBB	11	5248168	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08	4169891	5248168	129758348	64	52442											
DCHS1	8642	broad.mit.edu	37	chr11	6662746	6662748	+	In_Frame_Del	DEL	CAG	-	-																															gcacctggcaccccagccccCagcagcagcagcagcagcag																										TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr11:6662746_6662748delCAG	uc001mem.1	-	2	507_509	c.97_99delCTG	c.(97-99)CTGdel	p.L33del		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	33					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCCAGCCCCcagcagcagcagc	0.527													---	---	---								-	6662748	-	-	6662746	7	5	281	1	0	1	0	1	0	0	0	0	4304	581	21	0	9877	0	DCHS1	11	6662746	In_Frame_Del	DEL	CAG	TCGA-D6-6826-01A-11D-1912-08	1414578	6662746	128343770	65	52443											
SPRYD5	84767	broad.mit.edu	37	chr11	55653267	55653267	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctccaactctcaggagcaCcggaatcacatacactgtcc	11	8	7	15	1	2	0	2	0	1	0	5	2	4	2	3	2	4	2	3	2	3	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr11:55653267C>G	uc010rip.1	+	2	455	c.363C>G	c.(361-363)CAC>CAG	p.H121Q	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	121	B box-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CTCAGGAGCACCGGAATCACA	0.488													5	28					0	0	0	0	G	55653267	G	G	55653267	3	3	281	1	0	0	0	0	1	0	0	0	15177	506	18	4	365	4	SPRYD5	11	55653267	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	48990521	55653267	79353249	66	52444											
OR1S2	219958	broad.mit.edu	37	chr11	57971290	57971290	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaagcaaattgtcagtgaCgacaaacacaatagaaaagt	21	6	7	7	1	1	2	1	1	0	1	1	3	1	2	0	0	2	1	0	0	8	2	rs138124206		TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr11:57971290C>T	uc010rkb.1	-	1	364	c.364G>A	c.(364-366)GTC>ATC	p.V122I		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	122	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				TTGTCAGTGACGACAAACACA	0.473													34	84					0	0	0	0	T	57971290	T	T	57971290	3	4	281	1	0	0	0	0	1	0	0	0	11027	536	19	1	616	1	OR1S2	11	57971290	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	2318023	57971290	77035226	67	52445											
MS4A7	58475	broad.mit.edu	37	chr11	60161321	60161321	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtcaaaaagagttcttcacGgtcttggatataagtaactc	13	12	9	7	1	4	1	2	0	2	1	5	2	4	2	0	3	1	2	0	3	5	6			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr11:60161321G>A	uc001npe.2	+	7	855	c.710G>A	c.(709-711)CGG>CAG	p.R237Q	MS4A7_uc001npf.2_Missense_Mutation_p.R237Q|MS4A7_uc001npg.2_Missense_Mutation_p.R192Q|MS4A7_uc001nph.2_Missense_Mutation_p.R192Q|MS4A14_uc001npi.2_Intron	NM_206939	NP_996822	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member	237	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2						AGTTCTTCACGGTCTTGGATA	0.373													15	81					0	0	0	0	A	60161321	A	A	60161321	3	1	281	1	0	0	0	0	1	0	0	0	9919	1116	39	1	732	1	MS4A7	11	60161321	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	2190031	60161321	74845195	68	52446											
TM7SF2	7108	broad.mit.edu	37	chr11	64883409	64883409	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctacctcctctacttcaccGcgctgctggtgcaccgtgag	5	11	9	16	3	3	1	1	1	2	0	4	1	4	1	4	1	4	3	4	1	2	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr11:64883409G>A	uc001oct.2	+	10	1288	c.1141G>A	c.(1141-1143)GCG>ACG	p.A381T	TM7SF2_uc010rny.1_Missense_Mutation_p.A265T|TM7SF2_uc001ocu.2_Missense_Mutation_p.A354T|TM7SF2_uc001ocv.2_Missense_Mutation_p.A402T|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	381					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						CTACTTCACCGCGCTGCTGGT	0.647													13	43					0	0	0	0	A	64883409	A	A	64883409	3	1	281	1	0	0	0	0	1	0	0	0	16040	1087	38	1	1179	1	TM7SF2	11	64883409	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	4722088	64883409	70123107	69	52447											
KAT5	10524	broad.mit.edu	37	chr11	65481258	65481258	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcggcagaatggagccgcccGtagggcagtggcagcccagc	8	4	16	13	3	0	1	0	0	0	1	1	2	0	2	3	4	3	4	3	4	2	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr11:65481258G>A	uc001ofi.2	+	7	780	c.530G>A	c.(529-531)CGT>CAT	p.R177H	KAT5_uc001ofj.2_Missense_Mutation_p.R125H|KAT5_uc001ofk.2_Missense_Mutation_p.R210H|KAT5_uc010roo.1_Missense_Mutation_p.R158H|KAT5_uc001ofl.2_5'UTR	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	177					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						GGAGCCGCCCGTAGGGCAGTG	0.532													4	16					0	0	0	0	A	65481258	A	A	65481258	3	1	281	1	0	0	0	0	1	0	0	0	8022	1145	40	1	651	1	KAT5	11	65481258	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	597849	65481258	69525258	70	52448											
PITPNM1	9600	broad.mit.edu	37	chr11	67262422	67262422	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctgtggccgctccttctcGatcacctgcacgggacaggg	6	8	13	14	3	2	0	1	0	1	0	4	2	3	1	3	3	2	3	3	3	0	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr11:67262422G>A	uc001olx.2	-	17	2826	c.2637C>T	c.(2635-2637)ATC>ATT	p.I879I	PITPNM1_uc001olw.2_Silent_p.I161I|PITPNM1_uc001oly.2_Silent_p.I879I|PITPNM1_uc001olz.2_Silent_p.I878I	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	879	DDHD.				brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						GCTCCTTCTCGATCACCTGCA	0.662													11	82					0	0	0	0	A	67262422	A	A	67262422	2	1	281	1	0	0	0	0	0	0	0	1	12005	1048	37	1		1	PITPNM1	11	67262422	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08	1781164	67262422	67744094	71	52449											
DYRK4	8798	broad.mit.edu	37	chr12	4702231	4702231	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtgaaatcctgggctacgCggagctgtggttcctgggtc	7	10	15	9	2	0	1	0	1	0	0	3	2	2	2	2	4	2	3	2	4	3	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr12:4702231C>T	uc001qmx.2	+	4	342	c.182C>T	c.(181-183)GCG>GTG	p.A61V	DYRK4_uc009zeh.1_Missense_Mutation_p.A176V|DYRK4_uc001qmy.1_Missense_Mutation_p.A61V	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	61						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			CTGGGCTACGCGGAGCTGTGG	0.458													15	59					0	0	0	0	T	4702231	T	T	4702231	3	4	281	1	0	0	0	0	1	0	0	0	4880	768	27	1	188	1	DYRK4	12	4702231	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08		4702231	129149664	72	52450											
ARID2	196528	broad.mit.edu	37	chr12	46243822	46243823	+	Frame_Shift_Ins	INS	-	C	C																															ttcttcatattttcaggaatINSccctcatggatcacaaacca																										TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr12:46243822_46243823insC	uc001ros.1	+	15	1916_1917	c.1916_1917insC	c.(1915-1917)ATCfs	p.I639fs	ARID2_uc001ror.2_Frame_Shift_Ins_p.I639fs|ARID2_uc009zkg.1_Frame_Shift_Ins_p.I95fs|ARID2_uc009zkh.1_Frame_Shift_Ins_p.I266fs|ARID2_uc001rou.1_5'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	639					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTTTCAGGAATCCCTCATGGAT	0.337													---	---	---								C	46243823	C	C	46243822	7	5	281	1	0	1	1	0	0	0	0	0	915	1435	50	0	1974	0	ARID2	12	46243822	Frame_Shift_Ins	INS	-	TCGA-D6-6826-01A-11D-1912-08	41541591	46243822	87608073	73	52451											
PTGES3	10728	broad.mit.edu	37	chr12	57058264	57058264	+	Nonstop_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caggtgatgacaatattcctTactccagatctggcatttct	10	14	7	10	0	2	3	0	2	2	1	4	3	4	3	2	2	1	1	2	2	3	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr12:57058264T>G	uc001slu.3	-	8	777	c.482A>C	c.(481-483)TAA>TCA	p.*161S	PTGES3_uc001slw.3_RNA|PTGES3_uc010sqs.1_Nonstop_Mutation_p.*128S|PTGES3_uc001slv.3_Nonstop_Mutation_p.*131S|PTGES3_uc010sqt.1_Nonstop_Mutation_p.*140S|PTGES3_uc009zox.2_RNA	NM_006601	NP_006592	Q15185	TEBP_HUMAN	prostaglandin-E synthase 3	161					chaperone cofactor-dependent protein refolding|hormone biosynthetic process|prostaglandin biosynthetic process|signal transduction|telomere maintenance	cytosol|telomerase holoenzyme complex	prostaglandin-E synthase activity|telomerase activity|unfolded protein binding				0						CAATATTCCTTACTCCAGATC	0.308													15	57					0	0	0	0	G	57058264	G	G	57058264	4	3	281	1	0	0	0	0	0	0	0	0	12811	1761	61	5	4	5	PTGES3	12	57058264	Nonstop_Mutation	SNP	T	TCGA-D6-6826-01A-11D-1912-08	10814442	57058264	76793631	74	52452											
TMTC2	160335	broad.mit.edu	37	chr12	83289957	83289957	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcgtagacagagaatgcaatGggaaaactgtaacaaatggc	17	6	12	6	1	0	2	0	0	0	2	0	4	0	3	0	2	3	3	0	2	7	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr12:83289957G>C	uc001szt.2	+	3	1447	c.1015G>C	c.(1015-1017)GGG>CGG	p.G339R	TMTC2_uc001szr.1_Missense_Mutation_p.G339R|TMTC2_uc001szs.1_Missense_Mutation_p.G339R|TMTC2_uc010suk.1_Missense_Mutation_p.G94R	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	339						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						AGAATGCAATGGGAAAACTGT	0.463													10	73					0	0	0	0	C	83289957	C	C	83289957	3	2	281	1	0	0	0	0	1	0	0	0	16327	1348	47	4	1025	4	TMTC2	12	83289957	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	26231693	83289957	50561938	75	52453											
TRPV4	59341	broad.mit.edu	37	chr12	110238456	110238456	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccccctcatccttgggctGgaagaagcgcccacgggcct	6	6	12	17	2	1	1	1	0	0	1	2	2	2	2	6	3	1	1	6	3	2	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr12:110238456G>A	uc001tpj.1	-	4	915	c.820C>T	c.(820-822)CAG>TAG	p.Q274*	TRPV4_uc001tpg.1_Nonsense_Mutation_p.Q240*|TRPV4_uc001tph.1_Intron|TRPV4_uc001tpi.1_Intron|TRPV4_uc001tpk.1_Nonsense_Mutation_p.Q274*|TRPV4_uc001tpl.1_Nonsense_Mutation_p.Q274*	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	274	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TCCTTGGGCTGGAAGAAGCGC	0.607													6	45					0	0	0	0	A	110238456	A	A	110238456	4	1	281	1	0	0	0	0	0	1	0	0	16665	1357	47	4	1843	4	TRPV4	12	110238456	Nonsense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	26948499	110238456	23613439	76	52454											
ATP2A2	488	broad.mit.edu	37	chr12	110780124	110780124	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcggtggctaaaaccgcctCtgagatggtcctggcggatg	7	9	15	10	3	1	1	0	1	1	1	2	3	2	2	3	5	2	1	3	5	2	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr12:110780124C>G	uc001tqk.3	+	15	2752	c.2189C>G	c.(2188-2190)TCT>TGT	p.S730C	ATP2A2_uc001tql.3_Missense_Mutation_p.S730C|ATP2A2_uc010sxy.1_Missense_Mutation_p.S703C	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	730	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						AAAACCGCCTCTGAGATGGTC	0.557													15	75					0	0	0	0	G	110780124	G	G	110780124	3	3	281	1	0	0	0	0	1	0	0	0	1139	913	32	2	2247	2	ATP2A2	12	110780124	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	541668	110780124	23071771	77	52455											
RNF6	6049	broad.mit.edu	37	chr13	26789040	26789040	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tactggtctactttccctttGggaattatgataaacagtgc	10	15	8	8	0	1	1	0	1	1	0	2	2	2	2	1	2	4	0	1	2	6	6			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr13:26789040G>A	uc001uqo.2	-	5	1270	c.979C>T	c.(979-981)CAA>TAA	p.Q327*	RNF6_uc001uqn.1_Intron|RNF6_uc010aak.2_Nonsense_Mutation_p.Q327*|RNF6_uc001uqp.2_Nonsense_Mutation_p.Q327*|RNF6_uc001uqq.2_Nonsense_Mutation_p.Q327*|RNF6_uc010tdk.1_Intron	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	327	Arg-rich.				negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		CTTTCCCTTTGGGAATTATGA	0.418													19	68					0	0	0	0	A	26789040	A	A	26789040	4	1	281	1	0	0	0	0	0	1	0	0	13563	1357	47	4	1082	4	RNF6	13	26789040	Nonsense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08		26789040	88380838	78	52456											
FARP1	10160	broad.mit.edu	37	chr13	99087939	99087939	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagatttgattggcattgaCaatcttgtggttccgggaag	11	13	12	5	1	1	3	0	2	1	1	2	4	2	4	1	3	0	2	1	3	3	5			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr13:99087939C>A	uc001vnj.2	+	19	2589	c.2253C>A	c.(2251-2253)GAC>GAA	p.D751E	FARP1_uc001vnh.2_Missense_Mutation_p.D751E	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	751					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TTGGCATTGACAATCTTGTGG	0.507													31	74					1.80694e-10	3.47247e-10	1	0	A	99087939	A	A	99087939	3	1	281	1	0	0	0	0	1	0	0	0	5708	477	17	4	2546	4	FARP1	13	99087939	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	72298899	99087939	16081939	79	52457											
STK24	8428	broad.mit.edu	37	chr13	99171636	99171636	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcaaccactttctgagtcCgattgtcaatgcctttgaac	9	13	8	11	1	2	2	1	2	1	0	3	3	3	2	3	1	3	1	3	1	3	3	rs147189846	by1000genomes	TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr13:99171636C>T	uc001vnm.1	-	2	405	c.170G>A	c.(169-171)CGG>CAG	p.R57Q	STK24_uc001vnn.1_Missense_Mutation_p.R45Q|STK24_uc010tim.1_Missense_Mutation_p.R45Q	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	57	Protein kinase.				cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TTTCTGAGTCCGATTGTCAAT	0.428													27	121					0	0	0	0	T	99171636	T	T	99171636	3	4	281	1	0	0	0	0	1	0	0	0	15359	652	23	1	1201	1	STK24	13	99171636	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	83697	99171636	15998242	80	52458											
RASA3	22821	broad.mit.edu	37	chr13	114817592	114817592	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacaggtgacgaaagctcCgaggaatttcacagtaaaag	16	6	12	7	2	1	1	1	1	0	0	2	5	2	3	1	3	1	2	1	3	4	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr13:114817592C>T	uc001vui.2	-	3	343	c.212G>A	c.(211-213)CGG>CAG	p.R71Q	RASA3_uc010tkk.1_Missense_Mutation_p.R39Q|RASA3_uc001vuj.2_5'UTR|RASA3_uc010tkl.1_RNA	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	71	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			ACGAAAGCTCCGAGGAATTTC	0.488													7	28					0	0	0	0	T	114817592	T	T	114817592	3	4	281	1	0	0	0	0	1	0	0	0	13127	652	23	1	2380	1	RASA3	13	114817592	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	15645956	114817592	352286	81	52459											
ARHGAP5	394	broad.mit.edu	37	chr14	32563530	32563530	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ataatcctgcaatcacttctGaccaggagttagatgataag	14	11	8	8	0	2	3	1	2	1	1	3	4	3	4	2	1	1	2	2	1	4	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr14:32563530G>A	uc001wrl.2	+	2	3894	c.3655G>A	c.(3655-3657)GAC>AAC	p.D1219N	ARHGAP5_uc001wrm.2_Missense_Mutation_p.D1219N|ARHGAP5_uc001wrn.2_Missense_Mutation_p.D1219N|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	1219					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		AATCACTTCTGACCAGGAGTT	0.353													16	94					0	0	0	0	A	32563530	A	A	32563530	3	1	281	1	0	0	0	0	1	0	0	0	886	1290	45	2	3657	2	ARHGAP5	14	32563530	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08		32563530	74786010	82	52460											
GPX2	2877	broad.mit.edu	37	chr14	65406430	65406430	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcttgtccttcaggtaggCgaagacaggatgctcgttct	8	11	13	9	2	2	1	1	0	1	1	4	4	3	2	1	3	2	4	1	3	2	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr14:65406430C>T	uc010tsn.1	-	3	436	c.349G>A	c.(349-351)GCC>ACC	p.A117T	CHURC1_uc010tsj.1_Intron|CHURC1_uc010tsk.1_Intron|FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|GPX2_uc001xhy.1_RNA	NM_002083	NP_002074	P18283	GPX2_HUMAN	glutathione peroxidase 2	117					response to oxidative stress	cytoplasm	electron carrier activity|glutathione peroxidase activity			ovary(1)	1				all cancers(60;0.00117)|OV - Ovarian serous cystadenocarcinoma(108;0.00557)|BRCA - Breast invasive adenocarcinoma(234;0.00971)	Glutathione(DB00143)	TTCAGGTAGGCGAAGACAGGA	0.537													14	56					0	0	0	0	T	65406430	T	T	65406430	3	4	281	1	0	0	0	0	1	0	0	0	6779	768	27	1	227	1	GPX2	14	65406430	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	32842900	65406430	41943110	83	52461											
NDUFB1	4707	broad.mit.edu	37	chr14	92588014	92588014	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcgcctacagcgaccccGagaccaagggcaacagggaa	13	2	12	14	3	1	1	1	0	0	1	1	4	1	2	4	2	4	1	4	2	4	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr14:92588014G>T	uc001yaf.2	-	1	140	c.108C>A	c.(106-108)CTC>CTA	p.L36L	NDUFB1_uc001yag.1_RNA|CPSF2_uc001yah.1_5'Flank	NM_004545	NP_004536	O75438	NDUB1_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	Error:Variant_position_missing_in_O75438_after_alignment					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.205)	NADH(DB00157)	CAGCGACCCCGAGACCAAGGG	0.711													9	63					3.07112e-06	5.51802e-06	1	0	T	92588014	T	T	92588014	2	4	281	1	0	0	0	0	0	0	0	1	10332	1045	37	3		3	NDUFB1	14	92588014	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08	27181584	92588014	14761526	84	52462											
RIN3	79890	broad.mit.edu	37	chr14	93118383	93118383	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accccatgccccaggtccccCagaccatccgaaccagccgc	9	3	7	22	2	0	1	0	0	0	1	2	2	2	1	10	1	3	0	10	1	1	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr14:93118383C>T	uc001yap.2	+	6	1141	c.989C>T	c.(988-990)CCA>CTA	p.P330L	RIN3_uc010auk.2_5'UTR|RIN3_uc001yaq.2_Missense_Mutation_p.P255L|RIN3_uc001yar.1_5'UTR|RIN3_uc001yas.1_5'UTR	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	330	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CCAGGTCCCCCAGACCATCCG	0.433													16	23					0	0	0	0	T	93118383	T	T	93118383	3	4	281	1	0	0	0	0	1	0	0	0	13438	594	21	4	1011	4	RIN3	14	93118383	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	530369	93118383	14231157	85	52463											
PPP1R14D	54866	broad.mit.edu	37	chr15	41120651	41120651	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agccagcgctggagctggccCcggtcatacttcactgtcag	7	8	12	14	2	3	0	3	0	0	0	3	1	3	1	3	3	4	2	3	3	1	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr15:41120651C>G	uc001zmy.2	-	1	257	c.189G>C	c.(187-189)CGG>CGC	p.R63R	PPP1R14D_uc001zmz.2_Silent_p.R63R	NM_017726	NP_060196	Q9NXH3	PP14D_HUMAN	protein phosphatase 1, regulatory subunit 14D	63					regulation of phosphorylation	cytoplasm	protein phosphatase inhibitor activity				0		all_cancers(109;6.29e-14)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.88e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GGAGCTGGCCCCGGTCATACT	0.597													8	68					0	0	0	0	G	41120651	G	G	41120651	2	3	281	1	0	0	0	0	0	0	0	1	12422	610	22	4		4	PPP1R14D	15	41120651	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08		41120651	61410741	86	52464											
SPTBN5	51332	broad.mit.edu	37	chr15	42173394	42173394	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcactccagggccctgggttCctcaggctttctcctggagg	4	11	12	14	0	3	0	2	0	1	0	6	1	5	1	4	5	0	2	4	5	0	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr15:42173394C>T	uc001zos.2	-	13	2724	c.2391G>A	c.(2389-2391)AGG>AGA	p.R797R		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	832					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCCCTGGGTTCCTCAGGCTTT	0.632													6	33					0	0	0	0	T	42173394	T	T	42173394	2	4	281	1	0	0	0	0	0	0	0	1	15188	854	30	2		2	SPTBN5	15	42173394	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08	1052743	42173394	60357998	87	52465											
ZSCAN29	146050	broad.mit.edu	37	chr15	43658483	43658483	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgctgcctaccaggccagaGtgagaggctgctgcttccag	7	8	13	13	1	0	2	0	1	0	2	2	3	1	2	4	2	4	4	4	2	1	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr15:43658483G>T	uc001zrk.1	-	3	1194	c.1047C>A	c.(1045-1047)CAC>CAA	p.H349Q	ZSCAN29_uc001zrj.1_Missense_Mutation_p.H229Q|ZSCAN29_uc010bdf.1_Missense_Mutation_p.H348Q|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Intron|ZSCAN29_uc001zrm.2_Missense_Mutation_p.H348Q	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	349					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		CCAGGCCAGAGTGAGAGGCTG	0.597													14	39					3.27435e-08	6.08094e-08	1	0	T	43658483	T	T	43658483	3	4	281	1	0	0	0	0	1	0	0	0	18303	1020	36	4	1523	4	ZSCAN29	15	43658483	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	1485089	43658483	58872909	88	52466											
NARG2	79664	broad.mit.edu	37	chr15	60745913	60745914	+	Frame_Shift_Del	DEL	TC	-	-																															acttcatgaaagatttgattTctctctctcatagtcatttt																										TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr15:60745913_60745914delTC	uc002agp.2	-	9	1248_1249	c.1013_1014delGA	c.(1012-1014)AGAfs	p.R338fs	NARG2_uc002ago.2_Frame_Shift_Del_p.R201fs|NARG2_uc002agq.3_Frame_Shift_Del_p.R6fs|NARG2_uc010bgk.2_Frame_Shift_Del_p.R338fs|NARG2_uc002agr.1_Frame_Shift_Del_p.R338fs	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	338						nucleus				ovary(1)|lung(1)	2						AGATTTGATTTCTCTCTCTCAT	0.317													---	---	---								-	60745914	-	-	60745913	7	5	281	1	0	1	0	1	0	0	0	0	10222	1780	62	0	1966	0	NARG2	15	60745913	Frame_Shift_Del	DEL	TC	TCGA-D6-6826-01A-11D-1912-08	17087430	60745913	41785479	89	52467											
IFT140	9742	broad.mit.edu	37	chr16	1642226	1642226	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccctcgtgagaccccatcttCagcaaacttccagaactgct	10	9	6	16	1	2	2	1	1	1	2	4	3	3	2	4	0	4	2	4	0	2	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr16:1642226C>T	uc002cmb.2	-	6	947	c.585G>A	c.(583-585)CTG>CTA	p.L195L		NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	195										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				ACCCCATCTTCAGCAAACTTC	0.507													11	74					0	0	0	0	T	1642226	T	T	1642226	2	4	281	1	0	0	0	0	0	0	0	1	7595	813	29	2		2	IFT140	16	1642226	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08		1642226	88712527	90	52468											
E4F1	1877	broad.mit.edu	37	chr16	2282237	2282237	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggagacggtgagatggccGaggccccgggcagcccccgc	6	3	18	14	4	0	2	0	1	0	2	0	5	0	2	5	5	1	1	5	5	0	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr16:2282237G>A	uc002cpm.2	+	4	529	c.481G>A	c.(481-483)GAG>AAG	p.E161K	E4F1_uc010bsi.2_Missense_Mutation_p.E161K|E4F1_uc010bsj.2_Missense_Mutation_p.E161K	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	161					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						TGAGATGGCCGAGGCCCCGGG	0.662													11	75					0	0	0	0	A	2282237	A	A	2282237	3	1	281	1	0	0	0	0	1	0	0	0	4896	1059	37	1	495	1	E4F1	16	2282237	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	640011	2282237	88072516	91	52469											
DNASE1L2	1775	broad.mit.edu	37	chr16	2287938	2287938	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccgcattgtggcctgtggCgcccgcctgcgccggagcct	3	7	15	16	5	0	0	0	0	0	0	0	2	0	1	6	3	2	1	6	3	0	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr16:2287938C>T	uc002cpo.2	+	5	1156	c.762C>T	c.(760-762)GGC>GGT	p.G254G	DNASE1L2_uc002cpn.2_Silent_p.G233G|DNASE1L2_uc002cpp.2_Silent_p.G254G|DNASE1L2_uc002cpq.2_Silent_p.G254G	NM_001374	NP_001365	Q92874	DNSL2_HUMAN	deoxyribonuclease I-like 2 precursor	254					DNA catabolic process	extracellular region	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|protein binding				0						TGGCCTGTGGCGCCCGCCTGC	0.672													4	13					0	0	0	0	T	2287938	T	T	2287938	2	4	281	1	0	0	0	0	0	0	0	1	4684	755	27	1		1	DNASE1L2	16	2287938	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08	5701	2287938	88066815	92	52470											
C16orf59	80178	broad.mit.edu	37	chr16	2514586	2514586	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgcaggggccgccctggctgGccctgtgccgggctgtgcac	2	6	17	16	3	0	0	0	0	0	0	0	0	0	0	4	5	2	4	4	5	0	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr16:2514586G>C	uc002cqh.2	+	10	1250	c.1219G>C	c.(1219-1221)GCC>CCC	p.A407P	C16orf59_uc002cqf.1_3'UTR|C16orf59_uc002cqg.1_3'UTR|C16orf59_uc002cqi.2_Missense_Mutation_p.A240P|C16orf59_uc010uwb.1_3'UTR	NM_025108	NP_079384	Q7L2K0	CP059_HUMAN	hypothetical protein LOC80178	407											0		Ovarian(90;0.17)				GCCCTGGCTGGCCCTGTGCCG	0.682													5	24					0	0	0	0	C	2514586	C	C	2514586	3	2	281	1	0	0	0	0	1	0	0	0	1829	1203	42	4	1257	4	C16orf59	16	2514586	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	226648	2514586	87840167	93	52471											
GRIN2A	2903	broad.mit.edu	37	chr16	10274133	10274135	+	In_Frame_Del	DEL	CGT	-	-																															tcgaagttcgcgctctgtcaCgtcgtggctgtgacccagca																										TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr16:10274133_10274135delCGT	uc002czo.3	-	2	682_684	c.134_136delACG	c.(133-138)GACGTG>GTG	p.D45del	GRIN2A_uc010uym.1_In_Frame_Del_p.D45del|GRIN2A_uc002czr.3_In_Frame_Del_p.D45del|GRIN2A_uc010buk.2_In_Frame_Del_p.D45del	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	45	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGCTCTGTCACGTCGTGGCTGTG	0.695													---	---	---								-	10274135	-	-	10274133	7	5	281	1	0	1	0	1	0	0	0	0	6818	536	19	0	4306	0	GRIN2A	16	10274133	In_Frame_Del	DEL	CGT	TCGA-D6-6826-01A-11D-1912-08	7759547	10274133	80080620	94	52472											
CACNG3	10368	broad.mit.edu	37	chr16	24372924	24372924	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcccaccctacaggtatCgattccggaggcggtcaagt	8	8	11	14	3	1	0	1	0	0	0	4	2	3	1	4	4	1	1	4	4	3	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr16:24372924C>A	uc002dmf.2	+	4	1888	c.688C>A	c.(688-690)CGA>AGA	p.R230R		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	230					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		CTACAGGTATCGATTCCGGAG	0.537													17	63					9.16793e-09	1.73172e-08	1	0	A	24372924	A	A	24372924	2	1	281	1	0	0	0	0	0	0	0	1	2570	876	31	3		3	CACNG3	16	24372924	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08	14098791	24372924	65981829	95	52473											
GPR114	221188	broad.mit.edu	37	chr16	57608852	57608852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcaggctgcgggagcgggCggatgcaccaagtgtcaggg	7	4	20	10	4	1	0	1	0	0	0	1	2	1	2	1	5	3	3	1	5	1	0	rs149449822		TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr16:57608852C>T	uc002elx.3	+	11	1419	c.1334C>T	c.(1333-1335)GCG>GTG	p.A445V	GPR114_uc010vhr.1_Missense_Mutation_p.R406W|GPR114_uc002ely.2_Missense_Mutation_p.A445V	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	445	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						CGGGAGCGGGCGGATGCACCA	0.652													9	33					0	0	0	0	T	57608852	T	T	57608852	3	4	281	1	0	0	0	0	1	0	0	0	6669	768	27	1	1372	1	GPR114	16	57608852	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	33235928	57608852	32745901	96	52474											
TP53	7157	broad.mit.edu	37	chr17	7578412	7578412	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catggtgggggcagcgcctcAcaacctccgtcatgtgctgt	6	9	13	13	2	2	0	2	0	0	0	3	0	3	0	3	3	3	2	3	3	1	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr17:7578412A>C	uc002gim.2	-	5	712	c.518T>G	c.(517-519)GTG>GGG	p.V173G	TP53_uc002gig.1_Missense_Mutation_p.V173G|TP53_uc002gih.2_Missense_Mutation_p.V173G|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V41G|TP53_uc010cng.1_Missense_Mutation_p.V41G|TP53_uc002gii.1_Missense_Mutation_p.V41G|TP53_uc010cnh.1_Missense_Mutation_p.V173G|TP53_uc010cni.1_Missense_Mutation_p.V173G|TP53_uc002gij.2_Missense_Mutation_p.V173G|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V80G|TP53_uc002gio.2_Missense_Mutation_p.V41G|TP53_uc010vug.1_Missense_Mutation_p.V134G	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(50)|p.V173M(39)|p.V173A(8)|p.V173V(8)|p.0?(7)|p.V173G(6)|p.V173fs*1(4)|p.V173fs*59(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.V173E(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCCTCACAACCTCCGT	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			32	35					0	0	0	0	C	7578412	C	C	7578412	3	2	281	1	0	0	0	0	1	0	0	0	16448	159	6	5	780	5	TP53	17	7578412	Missense_Mutation	SNP	A	TCGA-D6-6826-01A-11D-1912-08		7578412	73616798	97	52475											
DNAH2	146754	broad.mit.edu	37	chr17	7699949	7699949	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accaagatgcattacctcttCaaccttcgagacatctccaa	13	10	4	14	1	3	2	1	0	2	2	5	3	3	2	4	0	3	1	4	0	4	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr17:7699949C>G	uc002giu.1	+	49	7856	c.7842C>G	c.(7840-7842)TTC>TTG	p.F2614L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2614	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ATTACCTCTTCAACCTTCGAG	0.572													14	42					0	0	0	0	G	7699949	G	G	7699949	3	3	281	1	0	0	0	0	1	0	0	0	4624	825	29	2	8036	2	DNAH2	17	7699949	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	121537	7699949	73495261	98	52476											
ALOX12B	242	broad.mit.edu	37	chr17	7983127	7983127	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgttccctcgcccaggaacGgagccaccatgtcgtctgtg	7	8	11	15	4	1	0	0	0	1	0	4	2	2	2	4	2	2	1	4	2	1	1			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr17:7983127G>A	uc002gjy.1	-	7	1148	c.887C>T	c.(886-888)CCG>CTG	p.P296L	uc010cnq.1_RNA	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	296	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						GCCCAGGAACGGAGCCACCAT	0.527										Multiple Myeloma(8;0.094)			4	17					0	0	0	0	A	7983127	A	A	7983127	3	1	281	1	0	0	0	0	1	0	0	0	537	1116	39	1	1254	1	ALOX12B	17	7983127	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	283178	7983127	73212083	99	52477											
CCDC144A	9720	broad.mit.edu	37	chr17	16612763	16612763	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agtgacagtggcagtacaaaCaactataaaagcctgaaacc	18	6	8	9	0	0	2	0	2	0	0	0	2	0	2	2	1	5	2	2	1	7	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr17:16612763C>A	uc002gqk.1	+	5	1468	c.1392C>A	c.(1390-1392)AAC>AAA	p.N464K	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	464											0						GCAGTACAAACAACTATAAAA	0.348													5	70					0.000157383	0.000271732	1	0	A	16612763	A	A	16612763	3	1	281	1	0	0	0	0	1	0	0	0	2789	477	17	4	1410	4	CCDC144A	17	16612763	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	8629636	16612763	64582447	100	52478											
ABCA10	10349	broad.mit.edu	37	chr17	67178387	67178387	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	attcccataagaacaggaaaAcaattcaatttcttggtatt	16	13	5	7	0	2	1	1	0	1	1	3	2	3	2	1	2	2	1	1	2	7	7			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr17:67178387A>G	uc010dfa.1	-	23	3555	c.2676T>C	c.(2674-2676)TGT>TGC	p.C892C	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Silent_p.C493C	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	892	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GAACAGGAAAACAATTCAATT	0.294													4	21					0	0	0	0	G	67178387	G	G	67178387	2	3	281	1	0	0	0	0	0	0	0	1	29	41	2	5		5	ABCA10	17	67178387	Silent	SNP	A	TCGA-D6-6826-01A-11D-1912-08	50565624	67178387	14016823	101	52479											
DSEL	92126	broad.mit.edu	37	chr18	65180897	65180897	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagccaggtaaaagggtggCataatagaaccaaaagtgca	18	5	12	6	0	0	1	0	0	0	1	0	2	0	1	2	3	3	3	2	3	8	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr18:65180897C>A	uc002lke.1	-	2	2203	c.979G>T	c.(979-981)GCC>TCC	p.A327S		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	317						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				AAAAGGGTGGCATAATAGAAC	0.383													15	73					0.000219431	0.000375925	1	0	A	65180897	A	A	65180897	3	1	281	1	0	0	0	0	1	0	0	0	4797	710	25	4	2693	4	DSEL	18	65180897	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08		65180897	12896351	102	52480											
OCEL1	79629	broad.mit.edu	37	chr19	17337542	17337542	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gccgcgcgcgggacacgacgCcccccgcaggacccgcccat	6	1	13	21	8	0	0	0	0	0	0	0	3	0	2	6	2	0	1	6	2	0	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr19:17337542C>T	uc002nfp.2	+	2	112	c.110C>T	c.(109-111)GCC>GTC	p.A37V		NM_024578	NP_078854	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	37	Pro-rich.									central_nervous_system(1)	1						GGACACGACGCCCCCCGCAGG	0.756													13	6					0	0	0	0	T	17337542	T	T	17337542	3	4	281	1	0	0	0	0	1	0	0	0	10870	739	26	4	116	4	OCEL1	19	17337542	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08		17337542	41791441	103	52481											
SERTAD1	29950	broad.mit.edu	37	chr19	40929409	40929409	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgactgccagaggttccttCtcctcctcctcctcccgttt	3	14	6	18	2	1	1	0	0	1	1	8	2	6	1	7	1	1	2	7	1	0	3			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr19:40929409C>T	uc002ont.3	-	2	204	c.45G>A	c.(43-45)GAG>GAA	p.E15E		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	15					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAGGTTCCTTCTCCTCCTCCT	0.458													9	41					0	0	0	0	T	40929409	T	T	40929409	2	4	281	1	0	0	0	0	0	0	0	1	14185	912	32	2		2	SERTAD1	19	40929409	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08	23591867	40929409	18199574	104	52482											
ZNF404	342908	broad.mit.edu	37	chr19	44376738	44376738	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctctcaccatggtgaaatCtttgatgttgactaagttga	10	15	9	7	0	3	4	1	4	2	0	4	4	3	4	1	1	0	2	1	1	2	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr19:44376738C>G	uc002oxs.3	-	2	1628	c.1619G>C	c.(1618-1620)AGA>ACA	p.R540T		NM_001033719	NP_001028891	Q494X3	ZN404_HUMAN	zinc finger protein 404	543	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				ATGGTGAAATCTTTGATGTTG	0.343													5	16					0	0	0	0	G	44376738	G	G	44376738	3	3	281	1	0	0	0	0	1	0	0	0	17953	913	32	2	34	2	ZNF404	19	44376738	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	3447329	44376738	14752245	105	52483											
SNRPD2	6633	broad.mit.edu	37	chr19	46190835	46190835	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttgccggcgatgagcgggttCcgcaggaccacgatgactga	8	7	15	11	5	0	3	0	3	0	0	1	6	1	4	3	3	2	2	3	3	0	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr19:46190835C>G	uc002pcw.2	-	3	630	c.333G>C	c.(331-333)CGG>CGC	p.R111R	SNRPD2_uc002pcv.2_Silent_p.R101R	NM_004597	NP_004588	P62316	SMD2_HUMAN	small nuclear ribonucleoprotein D2 isoform 1	111					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00546)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.194)		TGAGCGGGTTCCGCAGGACCA	0.547													9	43					0	0	0	0	G	46190835	G	G	46190835	2	3	281	1	0	0	0	0	0	0	0	1	14929	842	30	2		2	SNRPD2	19	46190835	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08	1814097	46190835	12938148	106	52484											
C20orf46	55321	broad.mit.edu	37	chr20	1161695	1161695	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgagcagcaccgacaagaGcatgccgcccaccgtgagca	12	3	11	15	3	0	3	0	2	0	1	0	4	0	3	4	0	5	4	4	0	1	0			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr20:1161695G>A	uc010gaa.1	-	3	787	c.568C>T	c.(568-570)CTC>TTC	p.L190F	C20orf46_uc002weq.1_Missense_Mutation_p.L190F	NM_018354	NP_060824	Q9NUR3	CT046_HUMAN	hypothetical protein LOC55321	190	Helical; (Potential).					integral to membrane	protein binding			ovary(1)	1						ACCGACAAGAGCATGCCGCCC	0.652													4	42					0	0	0	0	A	1161695	A	A	1161695	3	1	281	1	0	0	0	0	1	0	0	0	2123	971	34	4	206	4	C20orf46	20	1161695	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08		1161695	61863825	107	52485											
BHLHE23	128408	broad.mit.edu	37	chr20	61637638	61637638	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcatgaggatatagttcttGgcgagcagcagcgtggcgat	9	10	15	7	3	1	1	0	1	1	0	1	4	1	2	0	3	4	4	0	3	2	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr20:61637638G>A	uc002yeb.2	-	1	750	c.441C>T	c.(439-441)GCC>GCT	p.A147A		NM_080606	NP_542173	Q8NDY6	BHE23_HUMAN	basic helix-loop-helix domain containing, class	147	Helix-loop-helix motif.				transcription, DNA-dependent	nucleus	DNA binding				0						TATAGTTCTTGGCGAGCAGCA	0.677													6	28					0	0	0	0	A	61637638	A	A	61637638	2	1	281	1	0	0	0	0	0	0	0	1	1425	1335	47	4		4	BHLHE23	20	61637638	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08	60475943	61637638	1387882	108	52486											
TOP3B	8940	broad.mit.edu	37	chr22	22314743	22314743	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgccgaggttggtgggcttgAgccggcgcccgctctccacc	3	8	15	15	4	1	1	0	1	1	0	2	2	1	1	5	4	2	3	5	4	0	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr22:22314743A>C	uc002zvs.2	-	14	2039	c.1604T>G	c.(1603-1605)CTC>CGC	p.L535R	TOP3B_uc010gtm.1_Missense_Mutation_p.L80R|TOP3B_uc002zvr.2_Missense_Mutation_p.L260R|TOP3B_uc010gtl.2_Missense_Mutation_p.L535R|TOP3B_uc002zvt.3_Missense_Mutation_p.L535R	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	535					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		GGTGGGCTTGAGCCGGCGCCC	0.612													6	55					0	0	0	0	C	22314743	C	C	22314743	3	2	281	1	0	0	0	0	1	0	0	0	16435	304	11	5	1004	5	TOP3B	22	22314743	Missense_Mutation	SNP	A	TCGA-D6-6826-01A-11D-1912-08		22314743	28989823	109	52487											
ZNF280A	129025	broad.mit.edu	37	chr22	22869426	22869426	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagtttaacccttttggaatCtctgctgtttatatctgaag	9	17	8	7	0	2	1	0	1	2	0	3	3	2	2	1	1	2	3	1	1	5	7			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr22:22869426C>G	uc002zwe.2	-	2	782	c.529G>C	c.(529-531)GAT>CAT	p.D177H	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		CTTTTGGAATCTCTGCTGTTT	0.453													14	88					0	0	0	0	G	22869426	G	G	22869426	3	3	281	1	0	0	0	0	1	0	0	0	17881	913	32	2	1103	2	ZNF280A	22	22869426	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	554683	22869426	28435140	110	52488											
GAS2L1	10634	broad.mit.edu	37	chr22	29708004	29708004	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcagctgttccggcgcctgGaagaggagttcctggccaat	8	8	14	11	2	0	1	0	0	0	1	2	3	2	3	4	4	2	4	4	4	2	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr22:29708004G>A	uc003afa.1	+	7	1763	c.1564G>A	c.(1564-1566)GAA>AAA	p.E522K	GAS2L1_uc010gvm.1_Intron|GAS2L1_uc003afb.1_3'UTR|GAS2L1_uc003afc.1_Missense_Mutation_p.E522K|GAS2L1_uc003afd.1_Nonsense_Mutation_p.W521*|GAS2L1_uc003afe.1_Nonsense_Mutation_p.W521*	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	522					cell cycle arrest	cytoplasm|cytoskeleton					0						CCGGCGCCTGGAAGAGGAGTT	0.692													30	132					0	0	0	0	A	29708004	A	A	29708004	3	1	281	1	0	0	0	0	1	0	0	0	6281	1183	41	2	1585	2	GAS2L1	22	29708004	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	6838578	29708004	21596562	111	52489											
DUSP18	150290	broad.mit.edu	37	chr22	31059928	31059928	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacaggcttttggttatctgCgagaggccgctgactgaggg	7	11	15	8	2	1	3	0	2	1	1	1	4	1	3	1	4	2	3	1	4	2	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chr22:31059928C>T	uc003aiu.2	-	2	564	c.63G>A	c.(61-63)TCG>TCA	p.S21S	SLC35E4_uc003ait.2_Intron|DUSP18_uc010gwa.1_RNA|DUSP18_uc003aiw.1_Silent_p.S21S	NM_152511	NP_689724	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	21						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						TGGTTATCTGCGAGAGGCCGC	0.557													5	63					0	0	0	0	T	31059928	T	T	31059928	2	4	281	1	0	0	0	0	0	0	0	1	4839	755	27	1		1	DUSP18	22	31059928	Silent	SNP	C	TCGA-D6-6826-01A-11D-1912-08	1351924	31059928	20244638	112	52490											
ARSD	414	broad.mit.edu	37	chrX	2833637	2833637	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacattatcaccatataaGccatgctgacttttccccag	11	12	4	14	0	1	1	1	1	0	0	3	1	3	1	5	0	2	1	5	0	3	5			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chrX:2833637G>T	uc004cqy.2	-	6	1036	c.960C>A	c.(958-960)GGC>GGA	p.G320G	ARSD_uc004cqz.1_Intron|ARSD_uc004cra.1_Silent_p.G320G	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	320						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACCATATAAGCCATGCTGAC	0.512													8	72					5.18039e-06	9.23279e-06	1	0	T	2833637	T	T	2833637	2	4	281	1	0	0	0	0	0	0	0	1	991	958	34	4		4	ARSD	23	2833637	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08		2833637	152436923	113	52491											
ZFX	7543	broad.mit.edu	37	chrX	24228854	24228854	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gactcttctaacttgaaaacGcatgtcaaaactaagcatag	16	10	6	9	1	3	1	1	1	2	0	3	2	3	1	0	0	4	2	0	0	7	5			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chrX:24228854G>A	uc004dbf.2	+	9	2037	c.1779G>A	c.(1777-1779)ACG>ACA	p.T593T	ZFX_uc004dbe.2_3'UTR|ZFX_uc011mjv.1_Silent_p.T632T|ZFX_uc010nfz.2_Silent_p.T249T	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	593	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2						ACTTGAAAACGCATGTCAAAA	0.438													7	67					0	0	0	0	A	24228854	A	A	24228854	2	1	281	1	0	0	0	0	0	0	0	1	17728	1074	38	1		1	ZFX	23	24228854	Silent	SNP	G	TCGA-D6-6826-01A-11D-1912-08	21395217	24228854	131041706	114	52492											
ZNF630	57232	broad.mit.edu	37	chrX	47919827	47919827	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catgtacccaattctcacttAcctgggtagatccaccttga	10	12	6	13	0	1	2	1	1	1	1	3	2	2	2	4	1	2	2	4	1	4	5			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chrX:47919827A>T	uc004div.3	-	4	490	c.238_splice	c.e4+1	p.D80_splice	ZNF630_uc010nhz.1_Splice_Site|ZNF630_uc004diw.2_Splice_Site	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						ATTCTCACTTACCTGGGTAGA	0.428													10	81					0	0	0	0	T	47919827	T	T	47919827	5	4	281	1	0	0	0	0	0	0	1	0	18121	405	14	5	1741	5	ZNF630	23	47919827	Splice_Site	SNP	A	TCGA-D6-6826-01A-11D-1912-08	23690973	47919827	107350733	115	52493											
TMEM35	59353	broad.mit.edu	37	chrX	100349902	100349902	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaatgctgaggagcaaccctCcttatatgagaaggcccctc	11	8	10	12	0	0	2	0	2	0	1	2	5	1	3	4	2	3	2	4	2	5	2			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chrX:100349902C>G	uc004egw.2	+	2	617	c.461C>G	c.(460-462)TCC>TGC	p.S154C		NM_021637	NP_067650	Q53FP2	TMM35_HUMAN	transmembrane protein 35	154						cytoplasmic membrane-bounded vesicle|integral to membrane|peroxisomal membrane					0						GAGCAACCCTCCTTATATGAG	0.532													11	71					0	0	0	0	G	100349902	G	G	100349902	3	3	281	1	0	0	0	0	1	0	0	0	16223	855	30	2	467	2	TMEM35	23	100349902	Missense_Mutation	SNP	C	TCGA-D6-6826-01A-11D-1912-08	52430075	100349902	54920658	116	52494											
FMR1NB	158521	broad.mit.edu	37	chrX	147106392	147106392	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttttatgttacagcgaaccgGccgatgatttacaaaggcag	12	11	10	8	3	0	1	0	1	0	0	0	3	0	1	2	2	4	2	2	2	5	5			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chrX:147106392G>A	uc004fcm.2	+	5	714	c.640G>A	c.(640-642)GCC>ACC	p.A214T		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	214	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCGAACCGGCCGATGATTT	0.378													11	76					0	0	0	0	A	147106392	A	A	147106392	3	1	281	1	0	0	0	0	1	0	0	0	5993	1203	42	4	658	4	FMR1NB	23	147106392	Missense_Mutation	SNP	G	TCGA-D6-6826-01A-11D-1912-08	46756490	147106392	8164168	117	52495											
MAGEA11	4110	broad.mit.edu	37	chrX	148794917	148794917	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagactttggactccaggTcagtagggaccttggccctt	8	10	13	10	0	1	1	1	0	0	1	2	4	2	3	3	5	0	1	3	5	1	4			TCGA-D6-6826-01A-11D-1912-08	TCGA-D6-6826-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	368030ac-f855-452a-a3d3-3698ab9a00dd	fec68b4e-7544-4bf0-8ceb-10e833435522	g.chrX:148794917T>A	uc004fdq.2	+	2	198	c.96_splice	c.e2+2	p.Q32_splice	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Intron	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a							cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GGACTCCAGGTCAGTAGGGAC	0.592													16	37					0	0	0	0	A	148794917	A	A	148794917	5	1	281	1	0	0	0	0	0	0	1	0	9216	1681	58	5	113	5	MAGEA11	23	148794917	Splice_Site	SNP	T	TCGA-D6-6826-01A-11D-1912-08	1688525	148794917	6475643	118	52496											
F13B	2165	broad.mit.edu	37	chr1	197036317	197036317	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagagttctcctgagattaTcaatatgatgataaaagtca	16	13	7	5	0	3	4	2	3	1	2	4	5	3	4	1	0	0	1	1	0	6	5			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr1:197036317T>C	uc001gtt.1	-	1	81	c.37A>G	c.(37-39)ATA>GTA	p.I13V		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	13					blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CCTGAGATTATCAATATGATG	0.299													9	69					0	0	0	0	C	197036317	C	C	197036317	3	2	282	1	0	0	0	0	1	0	0	0	5366	1435	50	5	1996	5	F13B	1	197036317	Missense_Mutation	SNP	T	TCGA-D6-6827-01A-11D-1912-08		197036317	52214304	1	52497											
FN1	2335	broad.mit.edu	37	chr2	216262570	216262570	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggcttggtcgtacacccAgctagaggaaggaatgcaaa	12	7	12	10	1	0	1	0	0	0	1	1	3	0	3	2	4	3	4	2	4	5	3			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr2:216262570A>C	uc002vfa.2	-	22	3616	c.3350T>G	c.(3349-3351)CTG>CGG	p.L1117R	FN1_uc002vfb.2_Missense_Mutation_p.L1117R|FN1_uc002vfc.2_Missense_Mutation_p.L1117R|FN1_uc002vfd.2_Missense_Mutation_p.L1117R|FN1_uc002vfe.2_Missense_Mutation_p.L1117R|FN1_uc002vff.2_Missense_Mutation_p.L1117R|FN1_uc002vfg.2_Missense_Mutation_p.L1117R|FN1_uc002vfh.2_Missense_Mutation_p.L1117R|FN1_uc002vfi.2_Missense_Mutation_p.L1117R|FN1_uc002vfj.2_Missense_Mutation_p.L1117R	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1117	|Fibronectin type-III 6.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCGTACACCCAGCTAGAGGAA	0.468													21	44					0	0	0	0	C	216262570	C	C	216262570	3	2	282	1	0	0	0	0	1	0	0	0	5994	202	7	5	4183	5	FN1	2	216262570	Missense_Mutation	SNP	A	TCGA-D6-6827-01A-11D-1912-08		216262570	26936803	2	52498											
COL6A3	1293	broad.mit.edu	37	chr2	238275793	238275793	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcagagttgtactggacaagCcccacttggatggagtcgcc	9	9	12	11	1	1	1	1	0	0	1	2	4	1	4	3	3	2	2	3	3	2	3			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr2:238275793C>A	uc002vwl.2	-	11	5322	c.5037G>T	c.(5035-5037)GGG>GGT	p.G1679G	COL6A3_uc002vwo.2_Silent_p.G1473G|COL6A3_uc010znj.1_Silent_p.G1072G	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1679	VWFA 9.|Nonhelical region.		G -> E (in BM).		axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACTGGACAAGCCCCACTTGGA	0.468													14	16					6.81908e-15	1.39004e-14	1	0	A	238275793	A	A	238275793	2	1	282	1	0	0	0	0	0	0	0	1	3716	726	26	4		4	COL6A3	2	238275793	Silent	SNP	C	TCGA-D6-6827-01A-11D-1912-08	22013223	238275793	4923580	3	52499											
BTC	685	broad.mit.edu	37	chr4	75681110	75681110	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccaccacgaagcggcatctCcctttgatgcagtaatgctt	9	10	9	13	2	1	1	0	1	1	0	2	2	1	1	3	1	3	4	3	1	2	3			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr4:75681110C>T	uc003hig.2	-	3	587	c.240G>A	c.(238-240)GGG>GGA	p.G80G		NM_001729	NP_001720	P35070	BTC_HUMAN	betacellulin precursor	80	Extracellular (Potential).|EGF-like.				positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|skin(1)	2			Lung(101;0.219)			AGCGGCATCTCCCTTTGATGC	0.532													47	85					0	0	0	0	T	75681110	T	T	75681110	2	4	282	1	0	0	0	0	0	0	0	1	1554	842	30	2		2	BTC	4	75681110	Silent	SNP	C	TCGA-D6-6827-01A-11D-1912-08		75681110	115473166	4	52500											
BCLAF1	9774	broad.mit.edu	37	chr6	136599279	136599279	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagtgaactgtactgagcAtgggagcatcagagcaagat	14	7	13	7	0	1	5	1	2	0	3	1	6	1	6	0	1	5	4	0	1	3	1			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr6:136599279A>G	uc003qgx.1	-	4	993	c.740T>C	c.(739-741)ATG>ACG	p.M247T	BCLAF1_uc003qgw.1_Missense_Mutation_p.M247T|BCLAF1_uc003qgy.1_Missense_Mutation_p.M245T|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.M245T	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	247					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGTACTGAGCATGGGAGCATC	0.453													20	102					0	0	0	0	G	136599279	G	G	136599279	3	3	282	1	0	0	0	0	1	0	0	0	1385	217	8	5	2062	5	BCLAF1	6	136599279	Missense_Mutation	SNP	A	TCGA-D6-6827-01A-11D-1912-08		136599279	34515788	5	52501											
MPDZ	8777	broad.mit.edu	37	chr9	13219563	13219563	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcttaactacttacccgcaActctggtgttgaagttgggg	8	13	10	10	1	2	1	0	1	2	0	2	1	2	1	1	3	4	3	1	3	5	5			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr9:13219563A>T	uc010mia.1	-	7	1138	c.1081T>A	c.(1081-1083)TTG>ATG	p.L361M	MPDZ_uc010mhy.2_Missense_Mutation_p.L361M|MPDZ_uc010mhz.2_Missense_Mutation_p.L361M|MPDZ_uc011lmn.1_Missense_Mutation_p.L361M|MPDZ_uc003zlb.3_Missense_Mutation_p.L361M	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	361					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CTTACCCGCAACTCTGGTGTT	0.418													17	23					0	0	0	0	T	13219563	T	T	13219563	3	4	282	1	0	0	0	0	1	0	0	0	9775	40	2	5	5200	5	MPDZ	9	13219563	Missense_Mutation	SNP	A	TCGA-D6-6827-01A-11D-1912-08		13219563	127993868	6	52502											
NFIB	4781	broad.mit.edu	37	chr9	14125721	14125722	+	Frame_Shift_Del	DEL	AC	-	-																															ctgtggagatgcagagctgaAcaatggcttttcaggcttct																										TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr9:14125721_14125722delAC	uc003zle.2	-	7	1404_1405	c.969_970delGT	c.(967-972)TTGTTCfs	p.L323fs	NFIB_uc003zld.2_Frame_Shift_Del_p.L71fs|NFIB_uc003zlf.2_Frame_Shift_Del_p.L323fs|NFIB_uc011lmo.1_Frame_Shift_Del_p.L323fs	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	323_324					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		GCAGAGCTGAACAATGGCTTTT	0.48			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								---	---	---								-	14125722	-	-	14125721	7	5	282	1	0	1	0	1	0	0	0	0	10425	43	2	0	304	0	NFIB	9	14125721	Frame_Shift_Del	DEL	AC	TCGA-D6-6827-01A-11D-1912-08	906158	14125721	127087710	7	52503											
GDF10	2662	broad.mit.edu	37	chr10	48429292	48429292	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttggcctgccacaggccGcgcggtgggggcgccagggc	3	5	18	15	4	0	0	0	0	0	0	1	0	1	0	5	6	1	0	5	6	0	1			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr10:48429292G>A	uc001jfb.2	-	2	1050	c.594C>T	c.(592-594)CGC>CGT	p.R198R	GDF10_uc009xnp.2_Silent_p.R197R|GDF10_uc009xnq.1_Silent_p.R198R	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	198					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						GCCACAGGCCGCGCGGTGGGG	0.721													24	24					0	0	0	0	A	48429292	A	A	48429292	2	1	282	1	0	0	0	0	0	0	0	1	6348	1074	38	1		1	GDF10	10	48429292	Silent	SNP	G	TCGA-D6-6827-01A-11D-1912-08		48429292	87105455	8	52504											
ACVR1B	91	broad.mit.edu	37	chr12	52387841	52387841	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagcccgcctgacggccctgCgcatcaagaagaccctctcc	8	5	9	19	3	2	3	1	1	1	2	3	3	2	3	5	1	2	1	5	1	2	0			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr12:52387841C>T	uc001rzn.2	+	9	1507	c.1465C>T	c.(1465-1467)CGC>TGC	p.R489C	ACVR1B_uc010snn.1_Missense_Mutation_p.R530C	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	489	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	GACGGCCCTGCGCATCAAGAA	0.612													20	73					0	0	0	0	T	52387841	T	T	52387841	3	4	282	1	0	0	0	0	1	0	0	0	221	768	27	1	1626	1	ACVR1B	12	52387841	Missense_Mutation	SNP	C	TCGA-D6-6827-01A-11D-1912-08		52387841	81464054	9	52505											
CYLD	1540	broad.mit.edu	37	chr16	50815182	50815182	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagtgtgcaggctgtacggAtggaaccttcagaggcactc	9	9	14	9	1	1	2	1	1	0	1	2	4	1	4	1	4	3	4	1	4	2	2			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr16:50815182A>T	uc002egp.1	+	10	1959	c.1544A>T	c.(1543-1545)GAT>GTT	p.D515V	CYLD_uc002ego.2_Missense_Mutation_p.D512V|CYLD_uc010cbs.1_Missense_Mutation_p.D512V|CYLD_uc002egq.1_Missense_Mutation_p.D512V|CYLD_uc002egr.1_Missense_Mutation_p.D512V|CYLD_uc002egs.1_Missense_Mutation_p.D512V	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	515	CAP-Gly 3.|Interaction with TRIP.|Interaction with IKBKG/NEMO.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				GGCTGTACGGATGGAACCTTC	0.448			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				42	31					0	0	0	0	T	50815182	T	T	50815182	3	4	282	1	0	0	0	0	1	0	0	0	4160	333	12	5	1574	5	CYLD	16	50815182	Missense_Mutation	SNP	A	TCGA-D6-6827-01A-11D-1912-08		50815182	39539571	10	52506											
DNAH9	1770	broad.mit.edu	37	chr17	11774927	11774927	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatggtaggttggaggactcGcttctgaaaacgtgaggtgg	10	10	16	5	2	1	2	0	2	1	0	2	4	1	4	0	6	1	3	0	6	4	3			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr17:11774927G>A	uc002gne.2	+	52	10134	c.10066G>A	c.(10066-10068)GCT>ACT	p.A3356T	DNAH9_uc010coo.2_Missense_Mutation_p.A2650T	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3356					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGGAGGACTCGCTTCTGAAAA	0.493													26	46					0	0	0	0	A	11774927	A	A	11774927	3	1	282	1	0	0	0	0	1	0	0	0	4630	1087	38	1	10272	1	DNAH9	17	11774927	Missense_Mutation	SNP	G	TCGA-D6-6827-01A-11D-1912-08		11774927	69420283	11	52507											
CD97	976	broad.mit.edu	37	chr19	14507206	14507206	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtaaaagctacggcacctgCgtcaacacccttggcagcta	11	8	9	13	2	1	0	1	0	0	0	1	0	1	0	2	2	5	5	2	2	5	4			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr19:14507206C>T	uc002myl.2	+	5	522	c.399C>T	c.(397-399)TGC>TGT	p.C133C	CD97_uc002mym.2_Silent_p.C133C|CD97_uc002myn.2_Intron	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	133	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						ACGGCACCTGCGTCAACACCC	0.567													9	117					0	0	0	0	T	14507206	T	T	14507206	2	4	282	1	0	0	0	0	0	0	0	1	3064	776	27	1		1	CD97	19	14507206	Silent	SNP	C	TCGA-D6-6827-01A-11D-1912-08		14507206	44621777	12	52508											
EMR2	30817	broad.mit.edu	37	chr19	14877869	14877869	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagctgccgagggtgttgacGcaggtgccgtagcttttaca	7	11	14	9	3	0	1	0	1	0	0	0	2	0	1	2	2	5	5	2	2	3	5	rs138601089		TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr19:14877869G>A	uc002mzp.1	-	6	864	c.408C>T	c.(406-408)TGC>TGT	p.C136C	EMR2_uc010dzs.1_5'Flank|EMR2_uc010xnw.1_Silent_p.C136C|EMR2_uc002mzo.1_Silent_p.C136C|EMR2_uc002mzq.1_Silent_p.C136C|EMR2_uc002mzr.1_Silent_p.C136C|EMR2_uc002mzs.1_Intron|EMR2_uc002mzt.1_Intron|EMR2_uc002mzu.1_Intron|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	136	Extracellular (Potential).|EGF-like 3; calcium-binding.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						GGGTGTTGACGCAGGTGCCGT	0.582													6	7					0	0	0	0	A	14877869	A	A	14877869	2	1	282	1	0	0	0	0	0	0	0	1	5129	1079	38	1		1	EMR2	19	14877869	Silent	SNP	G	TCGA-D6-6827-01A-11D-1912-08	370663	14877869	44251114	13	52509											
C22orf42	150297	broad.mit.edu	37	chr22	32554980	32554980	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttctttacctttggacaTcttcagcatcttcggcgtct	5	16	8	12	2	5	0	1	0	4	0	6	1	5	1	1	3	2	2	1	3	1	6			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr22:32554980T>C	uc003amd.2	-	1	264	c.223A>G	c.(223-225)ATG>GTG	p.M75V		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	75										ovary(1)|skin(1)	2						CCTTTGGACATCTTCAGCATC	0.547													68	151					0	0	0	0	C	32554980	C	C	32554980	3	2	282	1	0	0	0	0	1	0	0	0	2159	1435	50	5	568	5	C22orf42	22	32554980	Missense_Mutation	SNP	T	TCGA-D6-6827-01A-11D-1912-08		32554980	18749586	14	52510											
SOX10	6663	broad.mit.edu	37	chr22	38370169	38370180	+	In_Frame_Del	DEL	GGGGTGGTTGGA	-	-																															ccgactgcagctctgtcttcGgggtggttggaggggtgggt																										TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chr22:38370169_38370180delGGGGTGGTTGGA	uc003aun.1	-	4	1001_1012	c.723_734delTCCAACCACCCC	c.(721-735)CCTCCAACCACCCCG>CCG	p.241_245PPTTP>P	POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_In_Frame_Del_p.241_245PPTTP>P	NM_006941	NP_008872	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	241_245						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)					CTCTGTCTTCGGGGTGGTTGGAGGGGTGGGTG	0.646													---	---	---								-	38370180	-	-	38370169	7	5	282	1	0	1	0	1	0	0	0	0	15005	1116	39	0	670	0	SOX10	22	38370169	In_Frame_Del	DEL	GGGGTGGTTGGA	TCGA-D6-6827-01A-11D-1912-08	5815189	38370169	12934397	15	52511											
ERAS	3266	broad.mit.edu	37	chrX	48687628	48687628	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaccgggctcaggcacgccGcagggatgttggcaggcagc	7	4	16	14	3	1	0	1	0	0	0	1	1	1	1	3	5	1	6	3	5	0	1			TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chrX:48687628G>A	uc004dky.1	+	1	346	c.95G>A	c.(94-96)CGC>CAC	p.R32H		NM_181532	NP_853510	Q7Z444	RASE_HUMAN	ES cell expressed Ras precursor	32					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			lung(4)|urinary_tract(1)	5						CAGGCACGCCGCAGGGATGTT	0.657													5	17					0	0	0	0	A	48687628	A	A	48687628	3	1	282	1	0	0	0	0	1	0	0	0	5229	1087	38	1	97	1	ERAS	23	48687628	Missense_Mutation	SNP	G	TCGA-D6-6827-01A-11D-1912-08		48687628	106582932	16	52512											
PLXNB3	5365	broad.mit.edu	37	chrX	153040467	153040468	+	Frame_Shift_Ins	INS	-	G	G																															ccgctgcagcccaagcctgaINSggggccaggggaggacggcc																										TCGA-D6-6827-01A-11D-1912-08	TCGA-D6-6827-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	059be8f9-9536-40c0-a751-5fe529a2f01f	fddb2e4f-1d76-4108-9c87-14b55cc52055	g.chrX:153040467_153040468insG	uc004fii.2	+	24	4238_4239	c.4064_4065insG	c.(4063-4065)GAGfs	p.E1355fs	PLXNB3_uc010nuk.2_Frame_Shift_Ins_p.E1378fs|PLXNB3_uc011mzd.1_Frame_Shift_Ins_p.E994fs|PLXNB3_uc004fij.1_RNA|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1355	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCAAGCCTGAGGGGCCAGGGG	0.688													---	---	---								G	153040468	G	G	153040467	7	5	282	1	0	1	1	0	0	0	0	0	12180	304	11	0	4272	0	PLXNB3	23	153040467	Frame_Shift_Ins	INS	-	TCGA-D6-6827-01A-11D-1912-08	104352839	153040467	2230093	17	52513											
AHDC1	27245	broad.mit.edu	37	chr1	27876046	27876046	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccttccgggactctgggcGagaggctgagagggcaaagt	8	7	17	9	2	1	2	0	1	1	2	2	5	2	3	2	4	1	2	2	4	1	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr1:27876046G>A	uc009vsy.2	-	6	3550	c.2581C>T	c.(2581-2583)CGC>TGC	p.R861C	AHDC1_uc009vsz.1_Missense_Mutation_p.R861C	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	861							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GACTCTGGGCGAGAGGCTGAG	0.652													5	53					0	0	0	0	A	27876046	A	A	27876046	3	1	283	1	0	0	0	0	1	0	0	0	412	1058	37	1	2234	1	AHDC1	1	27876046	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08		27876046	221374575	1	52514											
ZBTB8A	653121	broad.mit.edu	37	chr1	33065901	33065901	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attccagatggcacttgagtGaagatgagaatagatcctat	14	11	10	6	0	0	6	0	3	0	4	2	7	2	6	2	1	0	1	2	1	4	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr1:33065901G>A	uc001bvn.2	+	5	1692	c.1207G>A	c.(1207-1209)GAA>AAA	p.E403K	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_3'UTR|ZBTB8OS_uc001bvo.1_RNA	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	403					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCACTTGAGTGAAGATGAGAA	0.423													4	36					0	0	0	0	A	33065901	A	A	33065901	3	1	283	1	0	0	0	0	1	0	0	0	17623	1291	45	2	1217	2	ZBTB8A	1	33065901	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	5189855	33065901	216184720	2	52515											
ADC	113451	broad.mit.edu	37	chr1	33583621	33583621	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acacgtaggggactggctggTctttgacaacatgggcgcct	8	9	14	10	2	1	1	0	1	1	0	1	2	1	2	1	5	1	2	1	5	2	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr1:33583621T>G	uc001bwr.2	+	11	1735	c.1148T>G	c.(1147-1149)GTC>GGC	p.V383G	ADC_uc001bws.2_Missense_Mutation_p.V383G|ADC_uc009vue.2_Missense_Mutation_p.V383G|ADC_uc001bwt.1_Missense_Mutation_p.V288G|ADC_uc001bwu.2_Missense_Mutation_p.V288G|ADC_uc001bwv.2_Missense_Mutation_p.V288G|ADC_uc001bww.2_Missense_Mutation_p.V288G|ADC_uc001bwx.1_Missense_Mutation_p.V360G|ADC_uc009vug.2_Missense_Mutation_p.V403G	NM_052998	NP_443724	Q96A70	ADC_HUMAN	ODC antizyme inhibitor-2	383					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	GACTGGCTGGTCTTTGACAAC	0.637													5	57					0	0	0	0	G	33583621	G	G	33583621	3	3	283	1	0	0	0	0	1	0	0	0	287	1667	58	5	1178	5	ADC	1	33583621	Missense_Mutation	SNP	T	TCGA-DQ-5624-01A-01D-1870-08	517720	33583621	215667000	3	52516											
EIF2C3	192669	broad.mit.edu	37	chr1	36479255	36479255	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagtgcaaattatgaaacaGatccatttgttcaggagttt	14	13	9	5	0	1	2	1	1	0	1	2	4	2	3	1	1	2	3	1	1	4	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr1:36479255G>C	uc001bzp.2	+	10	1430	c.1174G>C	c.(1174-1176)GAT>CAT	p.D392H	EIF2C3_uc001bzq.2_Missense_Mutation_p.D158H	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	392					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTATGAAACAGATCCATTTGT	0.393													7	90					0	0	0	0	C	36479255	C	C	36479255	3	2	283	1	0	0	0	0	1	0	0	0	5029	942	33	2	1212	2	EIF2C3	1	36479255	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	2895634	36479255	212771366	4	52517											
LEPR	3953	broad.mit.edu	37	chr1	66067602	66067602	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agatggtcaaccagtacaatCcagtcacttgcggaaagcac	14	7	9	11	1	2	1	2	0	0	1	3	2	3	2	2	2	4	2	2	2	4	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr1:66067602C>T	uc001dci.2	+	10	1564	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I	LEPR_uc001dcg.2_Silent_p.I454I|LEPR_uc001dch.2_Silent_p.I454I|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Silent_p.I454I|LEPR_uc001dck.2_Silent_p.I454I	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	454	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CCAGTACAATCCAGTCACTTG	0.328													11	74					0	0	0	0	T	66067602	T	T	66067602	2	4	283	1	0	0	0	0	0	0	0	1	8768	845	30	2		2	LEPR	1	66067602	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	29588347	66067602	183183019	5	52518											
S100A7	6278	broad.mit.edu	37	chr1	153431379	153431379	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaagttggggaagttctcCttcatcatcgtcagcaggct	9	11	12	9	1	4	0	3	0	1	0	6	2	4	2	1	4	1	4	1	4	2	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr1:153431379C>T	uc001fbv.1	-	2	182	c.111G>A	c.(109-111)AAG>AAA	p.K37K		NM_002963	NP_002954	P31151	S10A7_HUMAN	S100 calcium binding protein A7	37	EF-hand 1.				angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			skin(1)	1	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGAAGTTCTCCTTCATCATCG	0.393													10	90					0	0	0	0	T	153431379	T	T	153431379	2	4	283	1	0	0	0	0	0	0	0	1	13848	680	24	4		4	S100A7	1	153431379	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	87363777	153431379	95819242	6	52519											
C1orf129	80133	broad.mit.edu	37	chr1	170952646	170952646	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagaatttctacccaaggagTttcaacaagacgaaagtaaa	18	9	7	7	1	2	2	1	0	1	2	2	4	2	3	1	1	2	2	1	1	9	5			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr1:170952646T>G	uc001ghg.2	+	9	830	c.700T>G	c.(700-702)TTT>GTT	p.F234V	C1orf129_uc009wvy.2_Missense_Mutation_p.F41V|C1orf129_uc010plz.1_Missense_Mutation_p.F234V	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	234							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ACCCAAGGAGTTTCAACAAGA	0.358													6	21					0	0	0	0	G	170952646	G	G	170952646	3	3	283	1	0	0	0	0	1	0	0	0	2005	1725	60	5	730	5	C1orf129	1	170952646	Missense_Mutation	SNP	T	TCGA-DQ-5624-01A-01D-1870-08	17521267	170952646	78297975	7	52520											
CFH	3075	broad.mit.edu	37	chr1	196712601	196712601	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacacctcctgtgtgaatccGcccacagtacaaaatgctta	12	9	7	13	1	0	1	0	1	0	0	2	2	2	1	4	0	2	2	4	0	5	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr1:196712601G>A	uc001gtj.3	+	20	3393	c.3153G>A	c.(3151-3153)CCG>CCA	p.P1051P		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1051	Sushi 18.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GTGTGAATCCGCCCACAGTAC	0.368													7	52					0	0	0	0	A	196712601	A	A	196712601	2	1	283	1	0	0	0	0	0	0	0	1	3298	1074	38	1		1	CFH	1	196712601	Silent	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	25759955	196712601	52538020	8	52521											
TRIM67	440730	broad.mit.edu	37	chr1	231344791	231344791	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcagctatgacgaccgggtgGtgctgggcacagctgcgttc	6	8	16	11	3	0	1	0	1	0	0	1	2	0	1	1	3	4	6	1	3	1	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr1:231344791G>T	uc009xfn.1	+	8	1960	c.1918G>T	c.(1918-1920)GTG>TTG	p.V640L		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	640	B30.2/SPRY.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				CGACCGGGTGGTGCTGGGCAC	0.612													5	113					1.23904e-05	1.31702e-05	1	0	T	231344791	T	T	231344791	3	4	283	1	0	0	0	0	1	0	0	0	16607	1261	44	4	1948	4	TRIM67	1	231344791	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	34632190	231344791	17905830	9	52522											
FMN2	56776	broad.mit.edu	37	chr1	240370553	240370553	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacagcctccaccacctcCatcccttctgtggtctgctg	5	11	6	19	0	3	0	1	0	2	0	6	0	6	0	6	1	2	1	6	1	0	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr1:240370553C>G	uc010pyd.1	+	5	2666	c.2441C>G	c.(2440-2442)CCA>CGA	p.P814R	FMN2_uc010pye.1_Missense_Mutation_p.P818R	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	814	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCACCACCTCCATCCCTTCTG	0.527													7	66					0	0	0	0	G	240370553	G	G	240370553	3	3	283	1	0	0	0	0	1	0	0	0	5982	594	21	4	2459	4	FMN2	1	240370553	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	9025762	240370553	8880068	10	52523											
ADCY3	109	broad.mit.edu	37	chr2	25043595	25043595	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgccactggacatacctGaatgttgcccatgacccccg	8	9	9	15	1	0	2	0	2	0	0	0	3	0	3	5	1	3	1	5	1	2	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr2:25043595G>A	uc002rfs.3	-	20	3449	c.3250C>T	c.(3250-3252)CAG>TAG	p.Q1084*	ADCY3_uc002rfr.3_Nonsense_Mutation_p.Q671*|ADCY3_uc010ykm.1_Nonsense_Mutation_p.Q1085*	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	1084	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GGACATACCTGAATGTTGCCC	0.597													9	73					0	0	0	0	A	25043595	A	A	25043595	4	1	283	1	0	0	0	0	0	1	0	0	295	1299	45	2	192	2	ADCY3	2	25043595	Nonsense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08		25043595	218155778	11	52524											
C2orf56	55471	broad.mit.edu	37	chr2	37474742	37474742	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataaaacaacacacatttttAaaaaatatgggtattgatgt	19	13	5	4	0	0	1	0	1	0	0	0	1	0	1	0	1	2	1	0	1	8	7			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr2:37474742A>T	uc002rqa.3	+	9	1155	c.1080A>T	c.(1078-1080)TTA>TTT	p.L360F	C2orf56_uc010ynj.1_RNA|C2orf56_uc002rqc.3_Missense_Mutation_p.L262F|C2orf56_uc010ynk.1_Missense_Mutation_p.L289F|C2orf56_uc010ynl.1_Missense_Mutation_p.L333F|C2orf56_uc010fah.2_RNA	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	360					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				ACACATTTTTAAAAAATATGG	0.343													9	51					0	0	0	0	T	37474742	T	T	37474742	3	4	283	1	0	0	0	0	1	0	0	0	2187	359	13	5	1114	5	C2orf56	2	37474742	Missense_Mutation	SNP	A	TCGA-DQ-5624-01A-01D-1870-08	12431147	37474742	205724631	12	52525											
GFPT1	2673	broad.mit.edu	37	chr2	69565126	69565126	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaactgtgtttgtgatcccCacagttaaagctcctctctc	8	13	6	14	0	1	1	0	1	1	0	5	1	3	1	4	0	2	3	4	0	3	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr2:69565126C>T	uc002sfh.2	-	14	1511	c.1332G>A	c.(1330-1332)GTG>GTA	p.V444V		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	462	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						TTGTGATCCCCACAGTTAAAG	0.448													52	90					0	0	0	0	T	69565126	T	T	69565126	2	4	283	1	0	0	0	0	0	0	0	1	6382	581	21	4		4	GFPT1	2	69565126	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	32090384	69565126	173634247	13	52526											
NCKAP5	344148	broad.mit.edu	37	chr2	133489551	133489551	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggcataggtagcgtcctgtCgagcgatttcccgagtctgg	6	11	14	10	4	1	0	0	0	1	0	4	3	3	0	2	3	2	2	2	3	2	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr2:133489551C>T	uc002ttp.2	-	17	5576	c.5202G>A	c.(5200-5202)TCG>TCA	p.S1734S	NCKAP5_uc002ttq.2_Silent_p.S415S	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1734							protein binding				0						AGCGTCCTGTCGAGCGATTTC	0.547													4	35					0	0	0	0	T	133489551	T	T	133489551	2	4	283	1	0	0	0	0	0	0	0	1	10277	871	31	1		1	NCKAP5	2	133489551	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	63924425	133489551	109709822	14	52527											
ZAK	51776	broad.mit.edu	37	chr2	174104208	174104208	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttggttttcacttgaaacCaggaactggcccacaggtaa	11	12	9	9	0	1	1	1	1	0	0	1	2	1	2	2	4	2	2	2	4	3	6			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr2:174104208C>G	uc002uhz.2	+	16	1543	c.1343C>G	c.(1342-1344)CCA>CGA	p.P448R	uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	448					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			CACTTGAAACCAGGAACTGGC	0.388													8	48					0	0	0	0	G	174104208	G	G	174104208	3	3	283	1	0	0	0	0	1	0	0	0	17580	594	21	4	1786	4	ZAK	2	174104208	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	40614657	174104208	69095165	15	52528											
TTN	7273	broad.mit.edu	37	chr2	179437281	179437281	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttagtgacctcttttaccttCagatcctgtggggggcctgg	5	14	12	10	0	2	2	1	1	1	1	3	2	3	2	4	4	1	0	4	4	2	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr2:179437281C>T	uc010zfg.1	-	275	66098	c.65874G>A	c.(65872-65874)CTG>CTA	p.L21958L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L15653L|TTN_uc010zfi.1_Silent_p.L15586L|TTN_uc010zfj.1_Silent_p.L15461L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22885							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTTACCTTCAGATCCTGTG	0.433													6	70					0	0	0	0	T	179437281	T	T	179437281	2	4	283	1	0	0	0	0	0	0	0	1	16803	813	29	2		2	TTN	2	179437281	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	5333073	179437281	63762092	16	52529											
TTN	7273	broad.mit.edu	37	chr2	179595271	179595271	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	actgcattggttgtgccctgCcttatttgtggcagaacaag	8	13	11	9	0	0	1	0	0	0	1	0	1	0	1	2	2	4	3	2	2	3	4	rs72648946	by1000genomes	TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr2:179595271C>G	uc010zfg.1	-	58	14481	c.14257G>C	c.(14257-14259)GCA>CCA	p.A4753P	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A1414P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5680							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTGCCCTGCCTTATTTGTG	0.383													13	113					0	0	0	0	G	179595271	G	G	179595271	3	3	283	1	0	0	0	0	1	0	0	0	16803	739	26	4	86748	4	TTN	2	179595271	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	157990	179595271	63604102	17	52530											
ZDBF2	57683	broad.mit.edu	37	chr2	207174876	207174876	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcttcgaaggggaaaaaaaAggttacctgggctgacttgc	12	10	12	7	1	1	1	0	1	1	0	2	3	1	2	1	4	2	2	1	4	6	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr2:207174876A>G	uc002vbp.2	+	5	5874	c.5624A>G	c.(5623-5625)AAG>AGG	p.K1875R		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1875							nucleic acid binding|zinc ion binding			ovary(3)	3						GGGAAAAAAAAGGTTACCTGG	0.418													8	44					0	0	0	0	G	207174876	G	G	207174876	3	3	283	1	0	0	0	0	1	0	0	0	17666	72	3	5	5634	5	ZDBF2	2	207174876	Missense_Mutation	SNP	A	TCGA-DQ-5624-01A-01D-1870-08	27579605	207174876	36024497	18	52531											
MDH1B	130752	broad.mit.edu	37	chr2	207615717	207615717	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaggtccccaaatggcactCtcatatctgtacacccttgt	10	11	7	13	0	2	1	1	0	2	1	4	1	3	1	3	2	1	2	3	2	3	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr2:207615717C>T	uc002vbs.2	-	6	1048	c.993G>A	c.(991-993)GAG>GAA	p.E331E	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Silent_p.E331E|MDH1B_uc010fuj.2_Silent_p.E233E|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	331					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		AAATGGCACTCTCATATCTGT	0.353													11	69					0	0	0	0	T	207615717	T	T	207615717	2	4	283	1	0	0	0	0	0	0	0	1	9462	912	32	2		2	MDH1B	2	207615717	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	440841	207615717	35583656	19	52532											
FANCD2	2177	broad.mit.edu	37	chr3	10088287	10088287	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgacctggtgatgcttttCatcatctatagcaccaatac	10	15	6	10	0	3	2	2	2	1	0	3	2	3	2	2	1	3	2	2	1	4	6			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr3:10088287C>T	uc003buw.2	+	15	1236	c.1158C>T	c.(1156-1158)TTC>TTT	p.F386F	FANCD2_uc003bux.1_Silent_p.F386F|FANCD2_uc003buy.1_Silent_p.F386F|FANCD2_uc010hcw.1_5'Flank	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	386					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TGATGCTTTTCATCATCTATA	0.373			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				6	39					0	0	0	0	T	10088287	T	T	10088287	2	4	283	1	0	0	0	0	0	0	0	1	5697	825	29	2		2	FANCD2	3	10088287	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08		10088287	187934143	20	52533											
SETD2	29072	broad.mit.edu	37	chr3	47164195	47164195	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttaatactatcatggctaTcatgtgttataaattcggac	12	15	6	8	1	2	0	2	0	0	0	3	1	2	1	1	2	1	2	1	2	7	7			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr3:47164195T>A	uc003cqs.2	-	3	1984	c.1931A>T	c.(1930-1932)GAT>GTT	p.D644V	SETD2_uc003cqv.2_Missense_Mutation_p.D633V	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	644					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ATCATGGCTATCATGTGTTAT	0.313			N|F|S|Mis		clear cell renal carcinoma								4	64					0	0	0	0	A	47164195	A	A	47164195	3	1	283	1	0	0	0	0	1	0	0	0	14196	1435	50	5	5839	5	SETD2	3	47164195	Missense_Mutation	SNP	T	TCGA-DQ-5624-01A-01D-1870-08	37075908	47164195	150858235	21	52534											
SETD2	29072	broad.mit.edu	37	chr3	47164342	47164342	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttaattcactaccttttGaacaaggtgtctgtaaacta	12	16	5	8	0	3	1	1	1	2	0	3	1	3	1	1	1	3	1	1	1	7	8			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr3:47164342G>A	uc003cqs.2	-	3	1837	c.1784C>T	c.(1783-1785)TCA>TTA	p.S595L	SETD2_uc003cqv.2_Missense_Mutation_p.S584L	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	595					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ACTACCTTTTGAACAAGGTGT	0.308			N|F|S|Mis		clear cell renal carcinoma								8	45					0	0	0	0	A	47164342	A	A	47164342	3	1	283	1	0	0	0	0	1	0	0	0	14196	1294	45	2	5986	2	SETD2	3	47164342	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	147	47164342	150858088	22	52535											
ATR	545	broad.mit.edu	37	chr3	142285095	142285095	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcagttttctttacaagttCtacagcaactaaaacaataa	16	13	4	8	0	3	0	1	0	2	0	3	0	3	0	0	0	5	3	0	0	8	8			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr3:142285095C>G	uc003eux.3	-	3	282	c.160G>C	c.(160-162)GAA>CAA	p.E54Q		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	54					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TTTACAAGTTCTACAGCAACT	0.328								Other_conserved_DNA_damage_response_genes					3	48					0	0	0	0	G	142285095	G	G	142285095	3	3	283	1	0	0	0	0	1	0	0	0	1206	922	32	2	7954	2	ATR	3	142285095	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	95120753	142285095	55737335	23	52536											
HLTF	6596	broad.mit.edu	37	chr3	148768099	148768099	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccggttctctaatacgatCaggaccataataaacataaa	16	9	7	9	2	2	0	1	0	1	0	3	2	2	1	2	3	2	1	2	3	7	6			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr3:148768099C>G	uc003ewq.1	-	15	1755	c.1537G>C	c.(1537-1539)GAT>CAT	p.D513H	HLTF_uc003ewr.1_Missense_Mutation_p.D513H|HLTF_uc003ews.1_Missense_Mutation_p.D512H|HLTF_uc010hve.1_Missense_Mutation_p.D512H	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	513	Helicase ATP-binding.				chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CTAATACGATCAGGACCATAA	0.299													6	114					0	0	0	0	G	148768099	G	G	148768099	3	3	283	1	0	0	0	0	1	0	0	0	7254	826	29	2	1536	2	HLTF	3	148768099	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	6483004	148768099	49254331	24	52537											
SI	6476	broad.mit.edu	37	chr3	164724661	164724661	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgtgaacatcgtaatgcaaaActgatgttccatcactaaga	15	11	7	8	1	1	3	1	2	0	1	3	3	2	3	1	0	3	3	1	0	5	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr3:164724661A>C	uc003fei.2	-	37	4411	c.4349T>G	c.(4348-4350)GTT>GGT	p.V1450G		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1450	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTAATGCAAAACTGATGTTCC	0.358										HNSCC(35;0.089)			10	32					0	0	0	0	C	164724661	C	C	164724661	3	2	283	1	0	0	0	0	1	0	0	0	14362	43	2	5	1182	5	SI	3	164724661	Missense_Mutation	SNP	A	TCGA-DQ-5624-01A-01D-1870-08	15956562	164724661	33297769	25	52538											
STX18	53407	broad.mit.edu	37	chr4	4543567	4543567	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcgcccttgggccgggggCtccggcggaacagctcgtcc	4	6	16	15	5	0	0	0	0	0	0	4	1	2	1	4	5	2	2	4	5	1	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr4:4543567C>T	uc003gic.2	-	1	209	c.125G>A	c.(124-126)AGC>AAC	p.S42N	uc003gid.2_5'Flank	NM_016930	NP_058626	Q9P2W9	STX18_HUMAN	syntaxin 18	42	Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|intracellular protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	SNAP receptor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.0534)		GGGCCGGGGGCTCCGGCGGAA	0.701													3	18					0	0	0	0	T	4543567	T	T	4543567	3	4	283	1	0	0	0	0	1	0	0	0	15407	797	28	4	926	4	STX18	4	4543567	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08		4543567	186610709	26	52539											
SHROOM3	57619	broad.mit.edu	37	chr4	77476765	77476765	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctctccctccaagcaggtcGaagaagggggcaaagcagac	12	5	12	12	1	1	2	0	0	1	2	5	3	3	2	2	3	2	3	2	3	4	0			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr4:77476765G>A	uc011cbx.1	+	2	1125	c.172G>A	c.(172-174)GAA>AAA	p.E58K		NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	58	PDZ.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CAAGCAGGTCGAAGAAGGGGG	0.602													5	36					0	0	0	0	A	77476765	A	A	77476765	3	1	283	1	0	0	0	0	1	0	0	0	14360	1059	37	1	178	1	SHROOM3	4	77476765	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	72933198	77476765	113677511	27	52540											
LRBA	987	broad.mit.edu	37	chr4	151392835	151392835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atatctctctgtgttgccatCgctgggtcatattagaagcc	8	14	9	10	1	3	1	1	0	2	1	5	1	3	1	2	1	2	2	2	1	4	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr4:151392835C>T	uc010ipj.2	-	44	7115	c.6641G>A	c.(6640-6642)CGA>CAA	p.R2214Q	LRBA_uc003ils.3_Missense_Mutation_p.R104Q|LRBA_uc003ilt.3_Missense_Mutation_p.R862Q|LRBA_uc003ilu.3_Missense_Mutation_p.R2203Q	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2214	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					GTGTTGCCATCGCTGGGTCAT	0.328													11	100					0	0	0	0	T	151392835	T	T	151392835	3	4	283	1	0	0	0	0	1	0	0	0	8981	884	31	1	2010	1	LRBA	4	151392835	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	73916070	151392835	39761441	28	52541											
FGA	2243	broad.mit.edu	37	chr4	155506821	155506821	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctcctctgttgtaactcGtgctactagtaaattgtttg	8	17	8	8	1	2	0	0	0	2	0	4	0	2	0	1	0	3	5	1	0	5	7			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr4:155506821G>A	uc003iod.1	-	5	1818	c.1760C>T	c.(1759-1761)ACG>ATG	p.T587M	FGA_uc003ioe.1_Missense_Mutation_p.T587M|FGA_uc003iof.1_3'UTR	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	587	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GTTGTAACTCGTGCTACTAGT	0.433													28	75					0	0	0	0	A	155506821	A	A	155506821	3	1	283	1	0	0	0	0	1	0	0	0	5862	1145	40	1	892	1	FGA	4	155506821	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	4113986	155506821	35647455	29	52542											
GRIA2	2891	broad.mit.edu	37	chr4	158242702	158242702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaatttatagaaagatggtCaacactggaagaaaaagaat	21	9	8	3	0	1	4	1	0	0	4	1	5	1	5	0	2	1	0	0	2	10	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr4:158242702C>T	uc003ipm.3	+	6	1292	c.833C>T	c.(832-834)TCA>TTA	p.S278L	GRIA2_uc011cit.1_Missense_Mutation_p.S231L|GRIA2_uc003ipl.3_Missense_Mutation_p.S278L|GRIA2_uc003ipk.3_Missense_Mutation_p.S231L|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	278	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GAAAGATGGTCAACACTGGAA	0.368													10	91					0	0	0	0	T	158242702	T	T	158242702	3	4	283	1	0	0	0	0	1	0	0	0	6807	838	29	2	855	2	GRIA2	4	158242702	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	2735881	158242702	32911574	30	52543											
DDX60L	91351	broad.mit.edu	37	chr4	169300950	169300950	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggctcttcgtctcttaaaaGacagcaatgaatgctttagc	11	13	8	9	1	2	2	0	1	2	1	4	2	2	2	0	1	3	3	0	1	5	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr4:169300950G>C	uc003irq.3	-	31	4369	c.4148C>G	c.(4147-4149)TCT>TGT	p.S1383C		NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1383							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TCTCTTAAAAGACAGCAATGA	0.323													6	30					0	0	0	0	C	169300950	C	C	169300950	3	2	283	1	0	0	0	0	1	0	0	0	4396	942	33	2	1004	2	DDX60L	4	169300950	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	11058248	169300950	21853326	31	52544											
LRRC14B	389257	broad.mit.edu	37	chr5	195216	195216	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcccaaggactgctacccCgagggtgccgcctacccaca	8	5	11	17	2	0	0	0	0	0	0	0	2	0	1	6	2	5	1	6	2	3	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr5:195216C>T	uc003jal.1	+	2	1321	c.1293C>T	c.(1291-1293)CCC>CCT	p.P431P		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	431										skin(1)	1						ACTGCTACCCCGAGGGTGCCG	0.672													25	119					0	0	0	0	T	195216	T	T	195216	2	4	283	1	0	0	0	0	0	0	0	1	9019	639	23	1		1	LRRC14B	5	195216	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08		195216	180720044	32	52545											
GHR	2690	broad.mit.edu	37	chr5	42711358	42711358	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtactcattgaaagtggAtaaggaatatgaagtgcgtg	14	11	13	3	1	1	2	1	2	0	0	1	4	1	4	0	2	2	1	0	2	6	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr5:42711358A>G	uc003jmt.2	+	7	711	c.668A>G	c.(667-669)GAT>GGT	p.D223G	GHR_uc011cpq.1_Missense_Mutation_p.D36G	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	223	Extracellular (Potential).|Fibronectin type-III.				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTGAAAGTGGATAAGGAATAT	0.398													45	83					0	0	0	0	G	42711358	G	G	42711358	3	3	283	1	0	0	0	0	1	0	0	0	6408	333	12	5	690	5	GHR	5	42711358	Missense_Mutation	SNP	A	TCGA-DQ-5624-01A-01D-1870-08	42516142	42711358	138203902	33	52546											
GZMA	3001	broad.mit.edu	37	chr5	54403737	54403737	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgctatgacccagccacaCgcgaaggtgaccttaaactt	12	8	8	13	2	0	2	0	2	0	0	0	3	0	2	3	1	3	1	3	1	4	3	rs150441571	byFrequency	TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr5:54403737C>T	uc003jpm.2	+	3	368	c.331C>T	c.(331-333)CGC>TGC	p.R111C		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	111	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				CCCAGCCACACGCGAAGGTGA	0.443													6	62					0	0	0	0	T	54403737	T	T	54403737	3	4	283	1	0	0	0	0	1	0	0	0	6954	536	19	1	341	1	GZMA	5	54403737	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	11692379	54403737	126511523	34	52547											
PCDHAC2	56134	broad.mit.edu	37	chr5	140347664	140347664	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggctgtctacaacatcaCggtgacagccacagatgggg	10	7	14	10	1	2	2	1	1	1	1	2	2	2	2	1	5	3	1	1	5	2	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr5:140347664C>T	uc003lii.2	+	1	1553	c.1313C>T	c.(1312-1314)ACG>ATG	p.T438M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.T438M	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	438	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACAACATCACGGTGACAGCC	0.552													26	93					0	0	0	0	T	140347664	T	T	140347664	3	4	283	1	0	0	0	0	1	0	0	0	11587	536	19	1	1315	1	PCDHAC2	5	140347664	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	85943927	140347664	40567596	35	52548											
PDGFRB	5159	broad.mit.edu	37	chr5	149500844	149500844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtccatgtagcttagcactgGagactcgttgatcaaagttg	10	12	11	8	1	1	2	1	1	0	1	3	3	2	2	1	1	2	5	1	1	3	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr5:149500844G>A	uc003lro.2	-	17	2855	c.2386C>T	c.(2386-2388)CCA>TCA	p.P796S	PDGFRB_uc010jhd.2_Missense_Mutation_p.P635S	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	796	Cytoplasmic (Potential).|Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTTAGCACTGGAGACTCGTTG	0.562			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								5	60					0	0	0	0	A	149500844	A	A	149500844	3	1	283	1	0	0	0	0	1	0	0	0	11716	1174	41	2	962	2	PDGFRB	5	149500844	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	9153180	149500844	31414416	36	52549											
GEMIN5	25929	broad.mit.edu	37	chr5	154287226	154287226	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtctgacacaccattctCaacaggtcctgagttctcct	8	13	7	13	0	3	2	1	2	3	0	6	2	4	2	3	2	1	1	3	2	1	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr5:154287226C>G	uc003lvx.3	-	16	2403	c.2320G>C	c.(2320-2322)GAG>CAG	p.E774Q	GEMIN5_uc011ddk.1_Missense_Mutation_p.E773Q	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	774					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ACACCATTCTCAACAGGTCCT	0.498													14	101					0	0	0	0	G	154287226	G	G	154287226	3	3	283	1	0	0	0	0	1	0	0	0	6368	835	29	2	2258	2	GEMIN5	5	154287226	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	4786382	154287226	26628034	37	52550											
SYCP2L	221711	broad.mit.edu	37	chr6	10903148	10903148	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cattttgcacgctgtccctcGagaagagagaaaaaaattcc	14	9	8	10	2	0	3	0	0	0	3	3	5	2	3	2	0	1	2	2	0	4	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr6:10903148G>C	uc003mzo.2	+	8	889	c.593G>C	c.(592-594)CGA>CCA	p.R198P	SYCP2L_uc011din.1_Missense_Mutation_p.R39P|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	198						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			GCTGTCCCTCGAGAAGAGAGA	0.388													5	40					0	0	0	0	C	10903148	C	C	10903148	3	2	283	1	0	0	0	0	1	0	0	0	15499	1058	37	3	623	3	SYCP2L	6	10903148	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08		10903148	160211919	38	52551											
MDN1	23195	broad.mit.edu	37	chr6	90440541	90440541	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcttcaactcatttttctGatattctgtaagtcgtacta	11	18	4	8	1	5	1	2	1	3	0	6	1	5	1	0	0	2	2	0	0	6	8			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr6:90440541G>A	uc003pnn.1	-	35	5160	c.5044C>T	c.(5044-5046)CAG>TAG	p.Q1682*		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	1682					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCATTTTTCTGATATTCTGTA	0.378													6	42					0	0	0	0	A	90440541	A	A	90440541	4	1	283	1	0	0	0	0	0	1	0	0	9468	1299	45	2	12018	2	MDN1	6	90440541	Nonsense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	79537393	90440541	80674526	39	52552											
LIN28B	389421	broad.mit.edu	37	chr6	105526438	105526438	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gccacccgcgagttctcaggGaagacaggaagcagaatccc	12	4	12	13	2	1	2	1	0	1	2	3	5	2	4	3	2	1	2	3	2	3	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr6:105526438G>A	uc003pqv.1	+	4	736	c.533G>A	c.(532-534)GGA>GAA	p.G178E	LIN28B_uc010kda.1_3'UTR	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	178					miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				AGTTCTCAGGGAAGACAGGAA	0.547													3	26					0	0	0	0	A	105526438	A	A	105526438	3	1	283	1	0	0	0	0	1	0	0	0	8848	1174	41	2	547	2	LIN28B	6	105526438	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	15085897	105526438	65588629	40	52553											
COX19	90639	broad.mit.edu	37	chr7	1015111	1015111	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtccgggggccgcggctggAagctcttggtcccgaaattc	5	9	15	12	4	1	0	0	0	1	0	4	2	3	1	3	5	1	2	3	5	2	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:1015111A>T	uc003sjp.1	-	1	125	c.35T>A	c.(34-36)TTC>TAC	p.F12Y	ADAP1_uc010ksc.2_5'UTR	NM_001031617	NP_001026788	Q49B96	COX19_HUMAN	COX19 cytochrome c oxidase assembly homolog	12						cytosol					0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;2.15e-15)		CCGCGGCTGGAAGCTCTTGGT	0.701													3	15					0	0	0	0	T	1015111	T	T	1015111	3	4	283	1	0	0	0	0	1	0	0	0	3783	246	9	5	249	5	COX19	7	1015111	Missense_Mutation	SNP	A	TCGA-DQ-5624-01A-01D-1870-08		1015111	158123552	41	52554											
SDK1	221935	broad.mit.edu	37	chr7	3991530	3991530	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcttttgaaccggccagggcGacggcctttcttttcatcat	6	13	10	12	3	3	1	2	1	1	0	3	2	3	1	3	3	1	1	3	3	1	5			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:3991530G>A	uc003smx.2	+	7	1267	c.1128G>A	c.(1126-1128)GCG>GCA	p.A376A		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	376	Ig-like C2-type 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CGGCCAGGGCGACGGCCTTTC	0.577													3	32					0	0	0	0	A	3991530	A	A	3991530	2	1	283	1	0	0	0	0	0	0	0	1	14033	1045	37	1		1	SDK1	7	3991530	Silent	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	2976419	3991530	155147133	42	52555											
DGKB	1607	broad.mit.edu	37	chr7	14378223	14378223	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctctattcgtcgatggcttCgtcttttcttagactctccc	4	18	6	13	3	4	1	0	0	4	1	9	2	4	1	1	1	0	1	1	1	2	6			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:14378223C>T	uc003ssz.2	-	22	2229	c.2042G>A	c.(2041-2043)CGA>CAA	p.R681Q	DGKB_uc011jxt.1_Missense_Mutation_p.R662Q|DGKB_uc003sta.2_Missense_Mutation_p.R681Q|DGKB_uc011jxu.1_Missense_Mutation_p.R680Q	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	681					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	TCGATGGCTTCGTCTTTTCTT	0.398													13	98					0	0	0	0	T	14378223	T	T	14378223	3	4	283	1	0	0	0	0	1	0	0	0	4488	884	31	1	403	1	DGKB	7	14378223	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	10386693	14378223	144760440	43	52556											
EGFR	1956	broad.mit.edu	37	chr7	55220268	55220268	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatctgtgcccagcagtgcTccgggcgctgccgtggcaag	5	8	14	14	3	2	0	1	0	1	0	3	0	3	0	3	2	4	4	3	2	1	0			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:55220268T>C	uc003tqk.2	+	6	904	c.658T>C	c.(658-660)TCC>CCC	p.S220P	EGFR_uc003tqh.2_Missense_Mutation_p.S220P|EGFR_uc003tqi.2_Missense_Mutation_p.S220P|EGFR_uc003tqj.2_Missense_Mutation_p.S220P|EGFR_uc010kzg.1_Missense_Mutation_p.S175P|EGFR_uc011kco.1_Missense_Mutation_p.S167P|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	220	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCAGCAGTGCTCCGGGCGCTG	0.597		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			5	557					0	0	0	0	C	55220268	C	C	55220268	3	2	283	1	0	0	0	0	1	0	0	0	4989	1551	54	5	680	5	EGFR	7	55220268	Missense_Mutation	SNP	T	TCGA-DQ-5624-01A-01D-1870-08	40842045	55220268	103918395	44	52557											
MAGI2	9863	broad.mit.edu	37	chr7	77885755	77885755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caccatgctgttagcagggtCttcaggatcaaagggcaaag	12	8	12	9	0	3	0	2	0	1	0	3	1	3	1	1	3	2	4	1	3	3	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:77885755C>T	uc003ugx.2	-	10	1806	c.1552G>A	c.(1552-1554)GAC>AAC	p.D518N	MAGI2_uc003ugy.2_Missense_Mutation_p.D518N|MAGI2_uc010ldx.1_Missense_Mutation_p.D127N|MAGI2_uc010ldy.1_Missense_Mutation_p.D127N|MAGI2_uc011kgr.1_Missense_Mutation_p.D350N|MAGI2_uc011kgs.1_Missense_Mutation_p.D355N	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	518						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TTAGCAGGGTCTTCAGGATCA	0.473													3	31					0	0	0	0	T	77885755	T	T	77885755	3	4	283	1	0	0	0	0	1	0	0	0	9244	913	32	2	2867	2	MAGI2	7	77885755	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	22665487	77885755	81252908	45	52558											
GRM3	2913	broad.mit.edu	37	chr7	86415655	86415655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaactcagtgataagtcgCgctatgattactttgccagg	11	11	9	10	2	1	2	1	2	0	0	2	2	1	2	2	1	3	1	2	1	4	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:86415655C>T	uc003uid.2	+	3	1646	c.547C>T	c.(547-549)CGC>TGC	p.R183C	GRM3_uc010lef.2_Missense_Mutation_p.R181C|GRM3_uc010leg.2_Missense_Mutation_p.R55C|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	183	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGATAAGTCGCGCTATGATTA	0.562													45	74					0	0	0	0	T	86415655	T	T	86415655	3	4	283	1	0	0	0	0	1	0	0	0	6837	768	27	1	553	1	GRM3	7	86415655	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	8529900	86415655	72723008	46	52559											
PDAP1	11333	broad.mit.edu	37	chr7	98998040	98998040	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgagcccttcaacgcctttgCgcttttgctagaacagggca	8	11	10	12	2	1	2	1	1	0	1	1	2	1	2	2	1	5	3	2	1	3	5			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:98998040C>T	uc003uqe.2	-	4	342	c.221G>A	c.(220-222)CGC>CAC	p.R74H		NM_014891	NP_055706	Q13442	HAP28_HUMAN	PDGFA associated protein 1	74					cell proliferation|signal transduction						0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)		Becaplermin(DB00102)	AACGCCTTTGCGCTTTTGCTA	0.557													7	35					0	0	0	0	T	98998040	T	T	98998040	3	4	283	1	0	0	0	0	1	0	0	0	11667	768	27	1	336	1	PDAP1	7	98998040	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	12582385	98998040	60140623	47	52560											
IMPDH1	3614	broad.mit.edu	37	chr7	128034398	128034398	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gcttctcaaacttgagctctCctgagtacatcatggaccta	10	12	7	12	0	3	2	2	2	2	0	5	3	3	3	2	1	3	3	2	1	3	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:128034398C>G	uc011kol.1	-	13	1563	c.1457G>C	c.(1456-1458)GGA>GCA	p.G486A	IMPDH1_uc011kom.1_Missense_Mutation_p.G481A|IMPDH1_uc003vmt.2_Missense_Mutation_p.G461A|IMPDH1_uc003vmu.2_Missense_Mutation_p.G571A|IMPDH1_uc003vmw.2_Missense_Mutation_p.G561A|IMPDH1_uc011kon.1_Missense_Mutation_p.G538A|IMPDH1_uc003vmv.2_Missense_Mutation_p.G535A|IMPDH1_uc003vmx.2_Missense_Mutation_p.G494A|IMPDH1_uc003vmy.2_Missense_Mutation_p.G502A|uc011koo.1_5'Flank	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	486					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CTTGAGCTCTCCTGAGTACAT	0.577													3	43					0	0	0	0	G	128034398	G	G	128034398	3	3	283	1	0	0	0	0	1	0	0	0	7765	855	30	2	95	2	IMPDH1	7	128034398	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	29036358	128034398	31104265	48	52561											
IMPDH1	3614	broad.mit.edu	37	chr7	128034977	128034977	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctggctgctgctgctcttctCcatggcatccagtgagccca	5	11	10	15	0	2	1	0	1	2	0	4	1	3	1	3	2	4	5	3	2	0	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:128034977C>G	uc011kol.1	-	11	1367	c.1261G>C	c.(1261-1263)GAG>CAG	p.E421Q	IMPDH1_uc011kom.1_Missense_Mutation_p.E416Q|IMPDH1_uc003vmt.2_Missense_Mutation_p.E396Q|IMPDH1_uc003vmu.2_Missense_Mutation_p.E506Q|IMPDH1_uc003vmw.2_Missense_Mutation_p.E496Q|IMPDH1_uc011kon.1_Missense_Mutation_p.E473Q|IMPDH1_uc003vmv.2_Missense_Mutation_p.E470Q|IMPDH1_uc003vmx.2_Missense_Mutation_p.E429Q|IMPDH1_uc003vmy.2_Missense_Mutation_p.E437Q|uc011koo.1_5'Flank	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	421					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CTGCTCTTCTCCATGGCATCC	0.637													3	62					0	0	0	0	G	128034977	G	G	128034977	3	3	283	1	0	0	0	0	1	0	0	0	7765	864	30	2	299	2	IMPDH1	7	128034977	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	579	128034977	31103686	49	52562											
FAM71F2	346653	broad.mit.edu	37	chr7	128317777	128317777	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcttggtgaaaattctgcaGaaaggcctgtccatcaccac	11	9	9	12	1	2	2	1	1	1	1	3	2	3	2	3	2	1	2	3	2	3	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:128317777G>C	uc003vnk.3	+	3	631	c.525G>C	c.(523-525)CAG>CAC	p.Q175H	FAM71F2_uc010llm.1_Missense_Mutation_p.Q166H|FAM71F2_uc003vnl.2_RNA|FAM71F2_uc010lln.1_RNA	NM_001012454	NP_001012457	Q6NXP2	F71F2_HUMAN	hypothetical protein LOC346653 isoform a	175											0						AAATTCTGCAGAAAGGCCTGT	0.488													4	43					0	0	0	0	C	128317777	C	C	128317777	3	2	283	1	0	0	0	0	1	0	0	0	5645	933	33	2	535	2	FAM71F2	7	128317777	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	282800	128317777	30820886	50	52563											
ATP6V0E2	155066	broad.mit.edu	37	chr7	149575776	149575776	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtccctggcagctggctcatCgccatcctggcgcagctgaa	6	8	12	15	2	1	1	1	1	0	0	4	1	3	1	3	3	2	5	3	3	1	0			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr7:149575776C>T	uc003wgr.2	+	3	1260	c.309C>T	c.(307-309)ATC>ATT	p.I103I	ATP6V0E2_uc003wgs.2_Intron|ATP6V0E2_uc003wgp.2_Silent_p.I103I|ATP6V0E2_uc003wgq.2_RNA|uc003wgt.1_5'Flank	NM_145230	NP_660265	Q8NHE4	VA0E2_HUMAN	ATPase, H+ transporting, V0 subunit isoform 1	54	Helical; (Potential).				ATP hydrolysis coupled proton transport|cell growth|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|vacuolar acidification	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuole	ATPase activity, coupled to transmembrane movement of ions|hydrogen ion transmembrane transporter activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00256)			GCTGGCTCATCGCCATCCTGG	0.642													7	28					0	0	0	0	T	149575776	T	T	149575776	2	4	283	1	0	0	0	0	0	0	0	1	1178	874	31	1		1	ATP6V0E2	7	149575776	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	21257999	149575776	9562887	51	52564											
CA8	767	broad.mit.edu	37	chr8	61139461	61139461	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatcttggaggatttcagTcacagccttcaagccaacat	13	11	7	10	0	4	0	3	0	1	0	4	2	4	2	2	2	3	0	2	2	4	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr8:61139461T>C	uc003xtz.1	-	5	795	c.547A>G	c.(547-549)ACT>GCT	p.T183A	CA8_uc003xua.1_Missense_Mutation_p.T183A	NM_004056	NP_004047	P35219	CAH8_HUMAN	carbonic anhydrase VIII	183					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				AGGATTTCAGTCACAGCCTTC	0.249													3	82					0	0	0	0	C	61139461	C	C	61139461	3	2	283	1	0	0	0	0	1	0	0	0	2535	1667	58	5	341	5	CA8	8	61139461	Missense_Mutation	SNP	T	TCGA-DQ-5624-01A-01D-1870-08		61139461	85224561	52	52565											
RALYL	138046	broad.mit.edu	37	chr8	85785593	85785593	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaattgactccttgctagggCgcctggagaagattgagaaa	13	9	12	7	1	0	4	0	2	0	3	1	6	1	4	2	2	1	1	2	2	4	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr8:85785593C>T	uc003ycq.3	+	8	1062	c.646C>T	c.(646-648)CGC>TGC	p.R216C	RALYL_uc003ycr.3_Missense_Mutation_p.R216C|RALYL_uc003ycs.3_Missense_Mutation_p.R216C|RALYL_uc010lzy.2_Missense_Mutation_p.R205C|RALYL_uc003yct.3_Missense_Mutation_p.R229C|RALYL_uc003ycu.3_Missense_Mutation_p.R143C|RALYL_uc003ycv.3_Missense_Mutation_p.R128C	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	216	Potential.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						CTTGCTAGGGCGCCTGGAGAA	0.423													3	12					0	0	0	0	T	85785593	T	T	85785593	3	4	283	1	0	0	0	0	1	0	0	0	13085	768	27	1	711	1	RALYL	8	85785593	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	24646132	85785593	60578429	53	52566											
DPYS	1807	broad.mit.edu	37	chr8	105456608	105456608	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcctccactgcctctgggcGgcacagctcgtggccctcag	4	8	12	17	2	2	0	1	0	1	0	4	0	3	0	4	3	3	2	4	3	0	0			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr8:105456608G>A	uc003yly.3	-	4	790	c.661C>T	c.(661-663)CGC>TGC	p.R221C		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	221					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GCCTCTGGGCGGCACAGCTCG	0.542													6	56					0	0	0	0	A	105456608	A	A	105456608	3	1	283	1	0	0	0	0	1	0	0	0	4768	1116	39	1	922	1	DPYS	8	105456608	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	19671015	105456608	40907414	54	52567											
ASAP1	50807	broad.mit.edu	37	chr8	131129204	131129204	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catactacagtagtgtagaaCtgtgtttcccagggccgtct	9	12	10	10	1	1	1	0	0	1	1	2	1	2	1	2	1	3	3	2	1	5	5			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr8:131129204C>A	uc003yta.1	-	20	1946	c.1918G>T	c.(1918-1920)GTT>TTT	p.V640F	ASAP1_uc003ysz.1_Missense_Mutation_p.V451F|ASAP1_uc011liw.1_Missense_Mutation_p.V633F	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	640	ANK 2.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TAGTGTAGAACTGTGTTTCCC	0.383													33	67					1.62565e-12	1.76499e-12	1	0	A	131129204	A	A	131129204	3	1	283	1	0	0	0	0	1	0	0	0	1012	565	20	4	1511	4	ASAP1	8	131129204	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	25672596	131129204	15234818	55	52568											
KCNK9	51305	broad.mit.edu	37	chr8	140631260	140631260	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaggctctggaacatgacCagtgtcagcgggatgcccag	9	6	13	13	1	2	1	1	1	1	0	2	3	2	3	3	3	3	1	3	3	1	0			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr8:140631260C>T	uc003yvf.1	-	2	430	c.366G>A	c.(364-366)CTG>CTA	p.L122L	KCNK9_uc003yvg.1_Silent_p.L122L|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	122	Helical; (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			GGAACATGACCAGTGTCAGCG	0.597													4	23					0	0	0	0	T	140631260	T	T	140631260	2	4	283	1	0	0	0	0	0	0	0	1	8111	581	21	4		4	KCNK9	8	140631260	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	9502056	140631260	5732762	56	52569											
GPR20	2843	broad.mit.edu	37	chr8	142367126	142367126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctggaagccactggtgaCgaagcagtagacgatggggt	10	6	17	8	2	0	2	0	1	0	1	0	5	0	3	2	5	2	2	2	5	3	1	rs150478338		TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr8:142367126C>T	uc003ywf.2	-	2	987	c.898G>A	c.(898-900)GTC>ATC	p.V300I		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	300	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CCACTGGTGACGAAGCAGTAG	0.647													7	70					0	0	0	0	T	142367126	T	T	142367126	3	4	283	1	0	0	0	0	1	0	0	0	6718	536	19	1	182	1	GPR20	8	142367126	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	1735866	142367126	3996896	57	52570											
KIAA2026	158358	broad.mit.edu	37	chr9	5923143	5923143	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgtgcttaactttgccttCttccttggagaaagctcttt	6	19	7	9	0	2	1	0	0	2	1	3	2	3	1	2	1	4	2	2	1	2	7			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr9:5923143C>T	uc003zjq.3	-	8	3069	c.2853G>A	c.(2851-2853)AAG>AAA	p.K951K	KIAA2026_uc010mht.2_Silent_p.K126K	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	951										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		ACTTTGCCTTCTTCCTTGGAG	0.388													16	149					0	0	0	0	T	5923143	T	T	5923143	2	4	283	1	0	0	0	0	0	0	0	1	8309	912	32	2		2	KIAA2026	9	5923143	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08		5923143	135290288	58	52571											
C9orf125	84302	broad.mit.edu	37	chr9	104239327	104239327	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgctgccccaggagagtcgCcgcagcctccggaggagcat	7	5	15	14	3	0	1	0	0	0	1	2	4	1	3	5	3	4	3	5	3	0	0			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr9:104239327C>T	uc004bbm.2	-	2	370	c.48G>A	c.(46-48)CGG>CGA	p.R16R	uc004bbl.1_5'Flank	NM_032342	NP_115718	Q9BRR3	CI125_HUMAN	hypothetical protein LOC84302	16						integral to membrane					0		Acute lymphoblastic leukemia(62;0.0527)				AGGAGAGTCGCCGCAGCCTCC	0.562													9	33					0	0	0	0	T	104239327	T	T	104239327	2	4	283	1	0	0	0	0	0	0	0	1	2466	726	26	4		4	C9orf125	9	104239327	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	98316184	104239327	36974104	59	52572											
SVEP1	79987	broad.mit.edu	37	chr9	113169875	113169875	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaagtttgatgaatgtgtagCaggagactcctttgtatttt	11	16	10	4	0	0	3	0	2	0	1	1	4	1	3	1	1	1	4	1	1	4	6			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr9:113169875C>T	uc010mtz.2	-	38	8342	c.8005G>A	c.(8005-8007)GCT>ACT	p.A2669T	SVEP1_uc010mty.2_Missense_Mutation_p.A595T	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2669	Sushi 21.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GAATGTGTAGCAGGAGACTCC	0.453													56	195					0	0	0	0	T	113169875	T	T	113169875	3	4	283	1	0	0	0	0	1	0	0	0	15486	710	25	4	2754	4	SVEP1	9	113169875	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	8930548	113169875	28043556	60	52573											
SVEP1	79987	broad.mit.edu	37	chr9	113171187	113171187	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actgacttatagcccgggttAcactgatacctcacttcact	10	12	6	13	1	2	2	2	2	0	0	2	2	2	2	2	1	3	1	2	1	4	5			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr9:113171187A>G	uc010mtz.2	-	38	7030	c.6693T>C	c.(6691-6693)TGT>TGC	p.C2231C	SVEP1_uc010mty.2_Silent_p.C157C	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2231	Sushi 14.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AGCCCGGGTTACACTGATACC	0.473													28	132					0	0	0	0	G	113171187	G	G	113171187	2	3	283	1	0	0	0	0	0	0	0	1	15486	389	14	5		5	SVEP1	9	113171187	Silent	SNP	A	TCGA-DQ-5624-01A-01D-1870-08	1312	113171187	28042244	61	52574											
CDNF	441549	broad.mit.edu	37	chr10	14862117	14862117	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttcagctctgccactctCatcttccgcaggtcaactga	7	12	7	15	1	5	1	3	1	3	0	7	1	6	1	2	1	4	3	2	1	1	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr10:14862117C>T	uc001inb.1	-	4	464	c.426G>A	c.(424-426)ATG>ATA	p.M142I	CDNF_uc010qbv.1_3'UTR|CDNF_uc001inc.1_Missense_Mutation_p.M33I	NM_001029954	NP_001025125	Q49AH0	CDNF_HUMAN	arginine-rich, mutated in early stage	142						extracellular region	growth factor activity				0						CTGCCACTCTCATCTTCCGCA	0.443													25	101					0	0	0	0	T	14862117	T	T	14862117	3	4	283	1	0	0	0	0	1	0	0	0	3183	826	29	2	141	2	CDNF	10	14862117	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08		14862117	120672630	62	52575											
GAD2	2572	broad.mit.edu	37	chr10	26575364	26575364	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctatgacactggagacaagGccttacagtgcggacgccac	11	6	11	13	2	0	2	0	1	0	1	0	4	0	3	3	3	2	0	3	3	3	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr10:26575364G>A	uc001isp.2	+	13	1830	c.1327G>A	c.(1327-1329)GCC>ACC	p.A443T	GAD2_uc001isq.2_Missense_Mutation_p.A443T	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	443					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TGGAGACAAGGCCTTACAGTG	0.438													23	60					0	0	0	0	A	26575364	A	A	26575364	3	1	283	1	0	0	0	0	1	0	0	0	6214	1203	42	4	1377	4	GAD2	10	26575364	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	11713247	26575364	108959383	63	52576											
SEMA4G	57715	broad.mit.edu	37	chr10	102737432	102737432	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttcctgcagcggctcaattCtacccacctctatgcatgtg	7	12	8	14	1	3	0	1	0	2	0	4	0	4	0	3	1	4	4	3	1	3	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr10:102737432C>T	uc010qpt.1	+	5	823	c.380C>T	c.(379-381)TCT>TTT	p.S127F	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krw.1_Missense_Mutation_p.S127F|SEMA4G_uc001krx.2_Missense_Mutation_p.S127F	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	127	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		CGGCTCAATTCTACCCACCTC	0.488													18	86					0	0	0	0	T	102737432	T	T	102737432	3	4	283	1	0	0	0	0	1	0	0	0	14101	913	32	2	394	2	SEMA4G	10	102737432	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	76162068	102737432	32797315	64	52577											
NOLC1	9221	broad.mit.edu	37	chr10	103917061	103917061	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgaggaggaggaggaagttCaagggcctccagcaaagaag	14	3	17	7	1	1	1	1	0	0	1	2	6	2	5	2	5	1	2	2	5	4	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr10:103917061C>T	uc001kuo.2	+	3	527	c.292C>T	c.(292-294)CAA>TAA	p.Q98*	NOLC1_uc001kup.2_Nonsense_Mutation_p.Q98*|NOLC1_uc001kuq.2_Nonsense_Mutation_p.Q99*|NOLC1_uc009xxb.1_Intron|NOLC1_uc001kur.2_Intron	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	98	11 X 12 AA approximate repeats of an acidic serine cluster.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		GGAGGAAGTTCAAGGGCCTCC	0.517													6	45					0	0	0	0	T	103917061	T	T	103917061	4	4	283	1	0	0	0	0	0	1	0	0	10583	827	29	2	302	2	NOLC1	10	103917061	Nonsense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	1179629	103917061	31617686	65	52578											
OR51A2	401667	broad.mit.edu	37	chr11	4976751	4976751	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgacatagccaacatggaaaGaaaatagtacatgggcccat	17	7	9	8	0	0	2	0	1	0	1	0	3	0	3	2	2	3	1	2	2	7	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr11:4976751G>C	uc010qyt.1	-	1	193	c.193C>G	c.(193-195)CTT>GTT	p.L65V		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AACATGGAAAGAAAATAGTAC	0.438													10	68					0	0	0	0	C	4976751	C	C	4976751	3	2	283	1	0	0	0	0	1	0	0	0	11140	942	33	2	750	2	OR51A2	11	4976751	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08		4976751	130029765	66	52579											
OR52A5	390054	broad.mit.edu	37	chr11	5153246	5153246	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aatattatgtcaaaccctagGattgcaaaggcaacaaatag	18	9	7	7	0	1	0	1	0	0	0	1	1	1	1	1	2	3	2	1	2	9	5			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr11:5153246G>T	uc010qyx.1	-	1	627	c.627C>A	c.(625-627)ATC>ATA	p.I209I		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAAACCCTAGGATTGCAAAGG	0.418													7	53					2.0095e-06	2.15101e-06	1	0	T	5153246	T	T	5153246	2	4	283	1	0	0	0	0	0	0	0	1	11164	1164	41	2		2	OR52A5	11	5153246	Silent	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	176495	5153246	129853270	67	52580											
SPRYD5	84767	broad.mit.edu	37	chr11	55653198	55653198	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatgtgggatgcacagagaGacaaagaagatgttctgtga	15	9	13	4	0	1	5	0	1	1	4	1	7	1	6	0	1	1	2	0	1	3	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr11:55653198G>C	uc010rip.1	+	2	386	c.294G>C	c.(292-294)GAG>GAC	p.E98D	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	98	B box-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TGCACAGAGAGACAAAGAAGA	0.488													3	43					0	0	0	0	C	55653198	C	C	55653198	3	2	283	1	0	0	0	0	1	0	0	0	15177	933	33	2	296	2	SPRYD5	11	55653198	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	50499952	55653198	79353318	68	52581											
SSRP1	6749	broad.mit.edu	37	chr11	57099146	57099146	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtggaggttctcacctctCaatgctgctgaaggtatact	9	12	11	9	0	2	1	2	1	2	0	4	2	2	2	1	4	3	4	1	4	4	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr11:57099146C>G	uc001njt.2	-	9	1486	c.1219G>C	c.(1219-1221)GAG>CAG	p.E407Q		NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	407					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						TCTCACCTCTCAATGCTGCTG	0.532													8	41					0	0	0	0	G	57099146	G	G	57099146	3	3	283	1	0	0	0	0	1	0	0	0	15260	835	29	2	946	2	SSRP1	11	57099146	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	1445948	57099146	77907370	69	52582											
C11orf9	745	broad.mit.edu	37	chr11	61551037	61551037	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggagaattcgatgtccatCacctcccagtactgtgctcc	8	11	8	14	1	1	1	1	0	0	1	5	3	4	1	4	1	2	2	4	1	2	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr11:61551037C>T	uc001nsc.1	+	23	3180	c.3084C>T	c.(3082-3084)ATC>ATT	p.I1028I	C11orf9_uc001nse.1_Silent_p.I988I|C11orf9_uc010rll.1_Silent_p.I414I	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	1028					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CGATGTCCATCACCTCCCAGT	0.617													9	110					0	0	0	0	T	61551037	T	T	61551037	2	4	283	1	0	0	0	0	0	0	0	1	1677	816	29	2		2	C11orf9	11	61551037	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	4451891	61551037	73455479	70	52583											
ARHGEF17	9828	broad.mit.edu	37	chr11	73020920	73020920	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagtaggggttctgggggcTggggcgtgtaccgctcccct	3	10	17	11	2	1	0	0	0	1	0	2	0	2	0	3	6	1	5	3	6	3	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr11:73020920T>C	uc001otu.2	+	1	1258	c.1237T>C	c.(1237-1239)TGG>CGG	p.W413R		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	413					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						TTCTGGGGGCTGGGGCGTGTA	0.652													6	42					0	0	0	0	C	73020920	C	C	73020920	3	2	283	1	0	0	0	0	1	0	0	0	900	1580	55	5	1239	5	ARHGEF17	11	73020920	Missense_Mutation	SNP	T	TCGA-DQ-5624-01A-01D-1870-08	11469883	73020920	61985596	71	52584											
USP35	57558	broad.mit.edu	37	chr11	77924770	77924770	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcactgggggaggggctttGatgaagacaaggatgaggat	11	7	18	5	1	0	4	0	3	0	1	0	7	0	7	0	6	0	2	0	6	2	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr11:77924770G>C	uc009yva.1	+	11	3214	c.2968G>C	c.(2968-2970)GAT>CAT	p.D990H	USP35_uc001ozc.2_Missense_Mutation_p.D558H|USP35_uc010rsp.1_Missense_Mutation_p.D422H|USP35_uc001ozd.2_Missense_Mutation_p.D601H|USP35_uc001ozf.2_Missense_Mutation_p.D721H	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	990					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			GAGGGGCTTTGATGAAGACAA	0.587													5	51					0	0	0	0	C	77924770	C	C	77924770	3	2	283	1	0	0	0	0	1	0	0	0	17134	1290	45	2	3006	2	USP35	11	77924770	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	4903850	77924770	57081746	72	52585											
OR10G4	390264	broad.mit.edu	37	chr11	123887072	123887072	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatctgaggccaggctccaTggatgccatggatggagttg	8	11	14	8	0	1	1	0	1	1	0	2	4	2	4	3	5	1	2	3	5	1	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr11:123887072T>C	uc010sac.1	+	1	791	c.791T>C	c.(790-792)ATG>ACG	p.M264T		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CCAGGCTCCATGGATGCCATG	0.517													18	55					0	0	0	0	C	123887072	C	C	123887072	3	2	283	1	0	0	0	0	1	0	0	0	10955	1464	51	5	793	5	OR10G4	11	123887072	Missense_Mutation	SNP	T	TCGA-DQ-5624-01A-01D-1870-08	45962302	123887072	11119444	73	52586											
FGD4	121512	broad.mit.edu	37	chr12	32793362	32793362	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaactgaagcagaagtggctGaaagtcatccttttagctgt	12	11	11	7	0	1	3	1	2	0	1	2	4	2	3	1	1	3	3	1	1	5	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr12:32793362G>A	uc001rkz.2	+	17	2673	c.2196G>A	c.(2194-2196)CTG>CTA	p.L732L	FGD4_uc001rlc.2_Silent_p.L817L|FGD4_uc001rla.2_Silent_p.L388L|FGD4_uc010ske.1_Silent_p.L844L|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	732	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					AGAAGTGGCTGAAAGTCATCC	0.493													5	67					0	0	0	0	A	32793362	A	A	32793362	2	1	283	1	0	0	0	0	0	0	0	1	5867	1277	45	2		2	FGD4	12	32793362	Silent	SNP	G	TCGA-DQ-5624-01A-01D-1870-08		32793362	101058533	74	52587											
HNRNPA1	3178	broad.mit.edu	37	chr12	54675202	54675202	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgaacagctgaggaagctCttcattggagggttgagctt	9	10	13	9	1	2	2	1	2	1	0	2	5	2	4	1	3	4	4	1	3	2	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr12:54675202C>G	uc001sfl.2	+	2	152	c.48C>G	c.(46-48)CTC>CTG	p.L16L	CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Silent_p.L16L|HNRNPA1_uc009zng.2_Silent_p.L16L|HNRNPA1_uc009znh.2_Silent_p.L16L|HNRNPA1_uc009zni.2_Silent_p.L16L|HNRNPA1_uc001sfn.2_Silent_p.L16L|HNRNPA1_uc001sfo.3_RNA|HNRNPA1_uc001sfp.1_5'UTR|HNRNPA1_uc009znj.1_5'Flank	NM_031157	NP_112420	P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	16	Globular A domain.|RRM 1.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3						TGAGGAAGCTCTTCATTGGAG	0.493													9	91					0	0	0	0	G	54675202	G	G	54675202	2	3	283	1	0	0	0	0	0	0	0	1	7296	900	32	2		2	HNRNPA1	12	54675202	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	21881840	54675202	79176693	75	52588											
CNPY2	10330	broad.mit.edu	37	chr12	56704786	56704786	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttaacattgtcagcctctCgggaaaagaattcaatgagt	13	12	8	8	1	3	2	2	1	1	1	4	3	3	3	1	1	2	0	1	1	5	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr12:56704786C>T	uc001sku.1	-	5	1002	c.461G>A	c.(460-462)CGA>CAA	p.R154Q		NM_014255	NP_055070	Q9Y2B0	CNPY2_HUMAN	canopy 2 homolog precursor	154	Saposin B-type.					endoplasmic reticulum|integral to plasma membrane	protein binding				0						GTCAGCCTCTCGGGAAAAGAA	0.478													7	106					0	0	0	0	T	56704786	T	T	56704786	3	4	283	1	0	0	0	0	1	0	0	0	3643	884	31	1	95	1	CNPY2	12	56704786	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	2029584	56704786	77147109	76	52589											
MYCBP2	23077	broad.mit.edu	37	chr13	77759426	77759426	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgcagtgatcaactccttCtgataaaatttttcttaaca	13	15	4	9	0	3	2	1	2	2	0	4	2	4	2	1	0	3	1	1	0	4	5			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr13:77759426C>G	uc001vkf.2	-	33	4508	c.4417G>C	c.(4417-4419)GAA>CAA	p.E1473Q	MYCBP2_uc010aev.2_Missense_Mutation_p.E877Q	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1473					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TCAACTCCTTCTGATAAAATT	0.378													14	366					0	0	0	0	G	77759426	G	G	77759426	3	3	283	1	0	0	0	0	1	0	0	0	10071	922	32	2	9713	2	MYCBP2	13	77759426	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08		77759426	37410452	77	52590											
SCEL	8796	broad.mit.edu	37	chr13	78214885	78214885	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactaaaatgattttagatgAattacaaatttgctgccatt	16	15	5	5	0	0	3	0	2	0	1	0	3	0	3	1	0	4	1	1	0	7	6			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr13:78214885A>G	uc001vki.2	+	31	2083	c.1913A>G	c.(1912-1914)GAA>GGA	p.E638G	SCEL_uc001vkj.2_Missense_Mutation_p.E618G|SCEL_uc010thx.1_Missense_Mutation_p.E596G	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	638	LIM zinc-binding.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		ATTTTAGATGAATTACAAATT	0.279													7	93					0	0	0	0	G	78214885	G	G	78214885	3	3	283	1	0	0	0	0	1	0	0	0	13953	246	9	5	2031	5	SCEL	13	78214885	Missense_Mutation	SNP	A	TCGA-DQ-5624-01A-01D-1870-08	455459	78214885	36954993	78	52591											
CARKD	55739	broad.mit.edu	37	chr13	111287916	111287916	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagaaaggagagcgcgacatCctctccaacggccagcaggg	12	3	13	13	3	1	2	0	0	1	2	3	4	2	2	3	3	3	1	3	3	2	0			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr13:111287916C>G	uc001vrb.2	+	8	767	c.753C>G	c.(751-753)ATC>ATG	p.I251M	CARKD_uc010tjj.1_Missense_Mutation_p.I233M|CARKD_uc001vqz.2_RNA|CARKD_uc001vra.2_RNA|CARKD_uc010tjk.1_Missense_Mutation_p.I141M|CARKD_uc010tjl.1_Missense_Mutation_p.I120M|CARKD_uc001vrc.2_Missense_Mutation_p.I251M			Q8IW45	CARKD_HUMAN	RecName: Full=Carbohydrate kinase domain-containing protein; Flags: Precursor;	251	YjeF C-terminal.									skin(1)	1						AGCGCGACATCCTCTCCAACG	0.622													4	52					0	0	0	0	G	111287916	G	G	111287916	3	3	283	1	0	0	0	0	1	0	0	0	2666	845	30	2	783	2	CARKD	13	111287916	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	33073031	111287916	3881962	79	52592											
SOS2	6655	broad.mit.edu	37	chr14	50655318	50655318	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcttctgcgatttcagttCtgacaagatcatagtagttt	9	18	7	7	1	5	2	2	1	3	1	5	3	5	2	0	0	1	3	0	0	3	7			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr14:50655318C>G	uc001wxs.3	-	5	709	c.611G>C	c.(610-612)AGA>ACA	p.R204T	SOS2_uc010tql.1_Missense_Mutation_p.R204T	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	204	DH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					GATTTCAGTTCTGACAAGATC	0.358													7	38					0	0	0	0	G	50655318	G	G	50655318	3	3	283	1	0	0	0	0	1	0	0	0	15001	913	32	2	3463	2	SOS2	14	50655318	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08		50655318	56694222	80	52593											
C14orf102	55051	broad.mit.edu	37	chr14	90756719	90756719	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gatagcccaacctatccatgCggccaacacagctagcccca	12	5	7	17	1	0	0	0	0	0	0	1	1	1	0	6	1	6	1	6	1	5	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr14:90756719C>T	uc001xyi.1	-	10	2106	c.2075G>A	c.(2074-2076)CGC>CAC	p.R692H	C14orf102_uc010atp.1_Missense_Mutation_p.R197H|C14orf102_uc001xyj.1_Missense_Mutation_p.R461H|C14orf102_uc001xyk.1_5'Flank	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	692							protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		CCTATCCATGCGGCCAACACA	0.488													3	36					0	0	0	0	T	90756719	T	T	90756719	3	4	283	1	0	0	0	0	1	0	0	0	1741	768	27	1	1439	1	C14orf102	14	90756719	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	40101401	90756719	16592821	81	52594											
CCNK	8812	broad.mit.edu	37	chr14	99959906	99959906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatcgcttctatatgtttCattccttcaagcaattccca	9	17	3	12	1	4	0	3	0	1	0	7	0	6	0	2	0	1	3	2	0	4	8			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr14:99959906C>T	uc001ygi.3	+	3	383	c.253C>T	c.(253-255)CAT>TAT	p.H85Y	CCNK_uc001ygg.3_Missense_Mutation_p.H85Y	NM_001099402	NP_001092872	O75909	CCNK_HUMAN	cyclin K isoform 1	85					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding				0		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)				CTATATGTTTCATTCCTTCAA	0.318													8	70					0	0	0	0	T	99959906	T	T	99959906	3	4	283	1	0	0	0	0	1	0	0	0	2945	826	29	2	259	2	CCNK	14	99959906	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	9203187	99959906	7389634	82	52595											
DYNC1H1	1778	broad.mit.edu	37	chr14	102449517	102449517	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaacacaaaatatcctattCagagggcactgcgtttggtg	13	10	10	8	1	1	1	1	0	0	1	2	2	2	1	1	2	2	2	1	2	5	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr14:102449517C>T	uc001yks.2	+	6	1287	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	375	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						ATATCCTATTCAGAGGGCACT	0.418													10	58					0	0	0	0	T	102449517	T	T	102449517	4	4	283	1	0	0	0	0	0	1	0	0	4863	827	29	2	1145	2	DYNC1H1	14	102449517	Nonsense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	2489611	102449517	4900023	83	52596											
ADSSL1	122622	broad.mit.edu	37	chr14	105208279	105208279	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacataggtgacgtgtatggCgtggtgaaagcctataccac	12	9	12	8	2	0	2	0	2	0	0	0	2	0	2	2	3	3	1	2	3	6	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr14:105208279C>T	uc001ypd.2	+	9	962	c.888C>T	c.(886-888)GGC>GGT	p.G296G	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Silent_p.G339G|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	296					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	ACGTGTATGGCGTGGTGAAAG	0.637													4	99					0	0	0	0	T	105208279	T	T	105208279	2	4	283	1	0	0	0	0	0	0	0	1	348	755	27	1		1	ADSSL1	14	105208279	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	2758762	105208279	2141261	84	52597											
EXD1	161829	broad.mit.edu	37	chr15	41476734	41476734	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcttgcagctttctccctgcGctgcttctggaagtccttga	4	15	9	13	1	3	1	0	1	3	0	5	2	4	2	2	1	4	4	2	1	1	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr15:41476734G>A	uc001znk.2	-	10	1131	c.940C>T	c.(940-942)CGC>TGC	p.R314C	EXD1_uc001znj.2_Missense_Mutation_p.R112C|EXD1_uc010ucv.1_Missense_Mutation_p.R372C	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	314					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						TTCTCCCTGCGCTGCTTCTGG	0.453													24	65					0	0	0	0	A	41476734	A	A	41476734	3	1	283	1	0	0	0	0	1	0	0	0	5321	1087	38	1	608	1	EXD1	15	41476734	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08		41476734	61054658	85	52598											
OAZ2	4947	broad.mit.edu	37	chr15	64982656	64982656	+	RNA	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggactgcatcccaagaagaGaccttcacctcggtgacctc	11	7	9	14	1	1	3	1	1	0	2	4	5	2	4	4	2	1	1	4	2	2	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr15:64982656G>A	uc002anp.2	-	3		c.486C>T						O95190	OAZ2_HUMAN	Homo sapiens ornithine decarboxylase antizyme 2 (OAZ2) mRNA, complete cds.						polyamine metabolic process|regulation of cellular amino acid metabolic process	cytosol|nucleus	ornithine decarboxylase inhibitor activity|protein binding				0					L-Ornithine(DB00129)	CCCAAGAAGAGACCTTCACCT	0.507													21	104					0	0	0	0	A	64982656	A	A	64982656	1	1	283	0	1	0	0	0	0	0	0	0	10859	929	33	2		2	OAZ2	15	64982656	RNA	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	23505922	64982656	37548736	86	52599											
CLDN9	9080	broad.mit.edu	37	chr16	3063730	3063730	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gtatcgtgctcaccgcggggGtcatcctcctcctcgccggc	3	9	12	17	5	2	0	2	0	0	0	7	0	5	0	5	3	1	2	5	3	1	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr16:3063730G>C	uc010uwo.1	+	1	1274	c.367G>C	c.(367-369)GTC>CTC	p.V123L		NM_020982	NP_066192	O95484	CLD9_HUMAN	claudin 9	123	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						CACCGCGGGGGTCATCCTCCT	0.657													13	85					0	0	0	0	C	3063730	C	C	3063730	3	2	283	1	0	0	0	0	1	0	0	0	3507	1261	44	4	369	4	CLDN9	16	3063730	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08		3063730	87291023	87	52600											
MEFV	4210	broad.mit.edu	37	chr16	3304457	3304457	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgcggagctggcgtttctgCgcagccggacctcggcctgg	3	7	16	15	6	1	0	0	0	1	0	2	2	1	2	4	5	3	3	4	5	0	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr16:3304457C>T	uc002cun.1	-	2	651	c.611G>A	c.(610-612)CGC>CAC	p.R204H		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	204					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding	p.R204C(1)		central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	GGCGTTTCTGCGCAGCCGGAC	0.766													4	27					0	0	0	0	T	3304457	T	T	3304457	3	4	283	1	0	0	0	0	1	0	0	0	9512	768	27	1	1770	1	MEFV	16	3304457	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	240727	3304457	87050296	88	52601											
NPIP	9284	broad.mit.edu	37	chr16	15029131	15029131	+	5'Flank	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgttctgaggcctccacgctGaggtgagggctctactgggg	5	9	16	11	2	2	3	0	3	2	0	3	3	3	3	2	5	1	3	2	5	1	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr16:15029131G>A	uc002dcy.3	+						NPIP_uc002dcx.3_RNA	NM_006985	NP_008916	Q9UND3	NPIP_HUMAN	nuclear pore complex interacting protein						mRNA transport|protein transport|transmembrane transport	nuclear membrane|nuclear pore					0						CCTCCACGCTGAGGTGAGGGC	0.637													9	20					0	0	0	0	A	15029131	A	A	15029131	1	1	283	0	1	0	0	0	0	0	0	0	10638	1305	45	2		2	NPIP	16	15029131	5'Flank	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	11724674	15029131	75325622	89	52602											
CDH8	1006	broad.mit.edu	37	chr16	62055210	62055210	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcattaaaacttgagactgaTtcatcggagccatgtaaatg	14	12	8	7	1	2	2	2	2	0	1	3	4	2	3	1	1	2	1	1	1	4	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr16:62055210T>C	uc002eog.1	-	2	350	c.98A>G	c.(97-99)AAT>AGT	p.N33S		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	33					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTGAGACTGATTCATCGGAGC	0.443													14	68					0	0	0	0	C	62055210	C	C	62055210	3	2	283	1	0	0	0	0	1	0	0	0	3131	1493	52	5	2345	5	CDH8	16	62055210	Missense_Mutation	SNP	T	TCGA-DQ-5624-01A-01D-1870-08	47026079	62055210	28299543	90	52603											
NLRP1	22861	broad.mit.edu	37	chr17	5462454	5462454	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggccagccaggacaccCagggcacaagacacagggcc	12	1	13	15	0	0	1	0	0	0	1	0	2	0	2	4	4	2	2	4	4	1	0			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr17:5462454C>T	uc002gci.2	-	4	2117	c.1562G>A	c.(1561-1563)TGG>TAG	p.W521*	NLRP1_uc002gcg.1_Nonsense_Mutation_p.W521*|NLRP1_uc002gck.2_Nonsense_Mutation_p.W521*|NLRP1_uc002gcj.2_Nonsense_Mutation_p.W521*|NLRP1_uc002gcl.2_Nonsense_Mutation_p.W521*|NLRP1_uc002gch.3_Nonsense_Mutation_p.W521*|NLRP1_uc010clh.2_Nonsense_Mutation_p.W521*	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	521	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				CCAGGACACCCAGGGCACAAG	0.478													7	94					0	0	0	0	T	5462454	T	T	5462454	4	4	283	1	0	0	0	0	0	1	0	0	10525	595	21	4	2990	4	NLRP1	17	5462454	Nonsense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08		5462454	75732756	91	52604											
TP53	7157	broad.mit.edu	37	chr17	7578183	7578184	+	Frame_Shift_Ins	INS	-	GGCT	GGCT																															ttgcaaaccagacctcaggcINSggctcatagggcaccaccac																								rs72661118		TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr17:7578183_7578184insGGCT	uc002gim.2	-	6	859_860	c.665_666insAGCC	c.(664-666)CCGfs	p.P222fs	TP53_uc002gig.1_Frame_Shift_Ins_p.P222fs|TP53_uc002gih.2_Frame_Shift_Ins_p.P222fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.P90fs|TP53_uc010cng.1_Frame_Shift_Ins_p.P90fs|TP53_uc002gii.1_Frame_Shift_Ins_p.P90fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.P222fs|TP53_uc010cni.1_Frame_Shift_Ins_p.P222fs|TP53_uc002gij.2_Frame_Shift_Ins_p.P222fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Ins_p.P129fs|TP53_uc002gio.2_Frame_Shift_Ins_p.P90fs|TP53_uc010vug.1_Frame_Shift_Ins_p.P183fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	222	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in a sporadic cancer; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> A (in a sporadic cancer; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.P222P(5)|p.P222L(5)|p.P222T(3)|p.P222S(2)|p.Y220_P223delYEPP(1)|p.?(1)|p.E221fs*2(1)|p.V218_E224delVPYEPPE(1)|p.P222Q(1)|p.P222fs*24(1)|p.P222fs*25(1)|p.P222A(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGACCTCAGGCGGCTCATAGGG	0.55		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								GGCT	7578184	GGCT	GGCT	7578183	7	5	283	1	0	1	1	0	0	0	0	0	16448	755	27	0	628	0	TP53	17	7578183	Frame_Shift_Ins	INS	-	TCGA-DQ-5624-01A-01D-1870-08	2115729	7578183	73617027	92	52605											
MYH10	4628	broad.mit.edu	37	chr17	8383453	8383453	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttcctgctcaagctgctcctCcagctgcccaatcttggcct	5	12	7	17	0	2	0	1	0	1	0	5	0	5	0	5	1	5	4	5	1	2	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr17:8383453C>G	uc002gll.2	-	38	5575	c.5479G>C	c.(5479-5481)GAG>CAG	p.E1827Q	MYH10_uc002glm.2_Missense_Mutation_p.E1858Q|MYH10_uc010cnx.2_Missense_Mutation_p.E1836Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1827	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						AGCTGCTCCTCCAGCTGCCCA	0.522													6	92					0	0	0	0	G	8383453	G	G	8383453	3	3	283	1	0	0	0	0	1	0	0	0	10083	864	30	2	467	2	MYH10	17	8383453	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	805270	8383453	72811757	93	52606											
DNAH9	1770	broad.mit.edu	37	chr17	11573107	11573107	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcttgtggaccacgtcactCacaggtacaacagttgtttt	10	13	8	10	1	3	0	2	0	1	0	3	1	3	1	1	2	2	3	1	2	2	5			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr17:11573107C>T	uc002gne.2	+	17	3417	c.3349C>T	c.(3349-3351)CAC>TAC	p.H1117Y	DNAH9_uc010coo.2_Missense_Mutation_p.H411Y	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1117	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCACGTCACTCACAGGTACAA	0.408													13	122					0	0	0	0	T	11573107	T	T	11573107	3	4	283	1	0	0	0	0	1	0	0	0	4630	826	29	2	3415	2	DNAH9	17	11573107	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	3189654	11573107	69622103	94	52607											
RICH2	9912	broad.mit.edu	37	chr17	12862203	12862203	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatatgatgctggagttttaCaaaaaggatgggtatgaact	15	12	11	3	0	0	2	0	2	0	0	0	4	0	4	0	3	3	3	0	3	7	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr17:12862203C>A	uc002gnr.3	+	16	1839	c.1512C>A	c.(1510-1512)TAC>TAA	p.Y504*	RICH2_uc010vvk.1_Nonsense_Mutation_p.Y504*|RICH2_uc010vvl.1_Nonsense_Mutation_p.Y504*|RICH2_uc002gns.3_Nonsense_Mutation_p.Y304*|RICH2_uc010vvm.1_Nonsense_Mutation_p.Y504*|RICH2_uc010vvn.1_RNA|RICH2_uc002gnt.1_Nonsense_Mutation_p.Y227*	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	504					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						TGGAGTTTTACAAAAAGGATG	0.572													3	20					0.00909568	0.00934151	1	0	A	12862203	A	A	12862203	4	1	283	1	0	0	0	0	0	1	0	0	13422	489	17	4	1574	4	RICH2	17	12862203	Nonsense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	1289096	12862203	68333007	95	52608											
OR4D2	124538	broad.mit.edu	37	chr17	56247069	56247069	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctttgtcttcctggggctctCgcagactcgggagctccagc	4	11	12	14	2	2	1	0	0	2	1	6	2	4	2	2	3	2	3	2	3	0	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr17:56247069C>G	uc010wnp.1	+	1	53	c.53C>G	c.(52-54)TCG>TGG	p.S18W		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						CTGGGGCTCTCGCAGACTCGG	0.468													11	89					0	0	0	0	G	56247069	G	G	56247069	3	3	283	1	0	0	0	0	1	0	0	0	11110	893	31	3	55	3	OR4D2	17	56247069	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	43384866	56247069	24948141	96	52609											
ACE	1636	broad.mit.edu	37	chr17	61573862	61573862	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catctaccagtccaaggaggCcgggcagcgcctggcgtgag	8	5	15	13	3	1	1	0	1	1	0	2	2	2	2	4	4	2	1	4	4	2	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr17:61573862C>T	uc002jau.1	+	23	3510	c.3488C>T	c.(3487-3489)GCC>GTC	p.A1163V	ACE_uc002jav.1_Missense_Mutation_p.A589V|ACE_uc010ddv.1_Missense_Mutation_p.A390V|ACE_uc010wpj.1_Intron|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Intron	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	1163	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TCCAAGGAGGCCGGGCAGCGC	0.627													5	41					0	0	0	0	T	61573862	T	T	61573862	3	4	283	1	0	0	0	0	1	0	0	0	136	739	26	4	3781	4	ACE	17	61573862	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	5326793	61573862	19621348	97	52610											
BPTF	2186	broad.mit.edu	37	chr17	65888058	65888058	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcgaatcatcaccagattgCggaatccagatagcaaactt	14	9	7	11	2	2	2	2	0	0	2	4	4	3	3	2	1	3	1	2	1	4	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr17:65888058C>T	uc002jgf.2	+	5	2024	c.1963C>T	c.(1963-1965)CGG>TGG	p.R655W	BPTF_uc002jge.2_Missense_Mutation_p.R781W|BPTF_uc010wqm.1_Missense_Mutation_p.R718W	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	781					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CACCAGATTGCGGAATCCAGA	0.478													9	21					0	0	0	0	T	65888058	T	T	65888058	3	4	283	1	0	0	0	0	1	0	0	0	1500	759	27	1	2367	1	BPTF	17	65888058	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	4314196	65888058	15307152	98	52611											
TMEM104	54868	broad.mit.edu	37	chr17	72832494	72832494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggaagacactcttccaccgcGagggcggcacgtacccgtgg	8	5	14	14	5	1	1	0	0	1	1	2	3	2	2	3	4	1	2	3	4	2	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr17:72832494G>A	uc002jls.3	+	10	1321	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Missense_Mutation_p.E387K	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	387	Cytoplasmic (Potential).					integral to membrane					0	all_lung(278;0.23)					CTTCCACCGCGAGGGCGGCAC	0.632													4	104					0	0	0	0	A	72832494	A	A	72832494	3	1	283	1	0	0	0	0	1	0	0	0	16084	1059	37	1	1193	1	TMEM104	17	72832494	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	6944436	72832494	8362716	99	52612											
ZFR2	23217	broad.mit.edu	37	chr19	3823275	3823275	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	attccgggcccaccggctgcGcatcagagcagcccgcggga	7	4	14	16	5	1	1	1	0	0	1	2	2	2	2	4	3	3	3	4	3	0	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr19:3823275G>A	uc002lyw.2	-	8	1352	c.1340C>T	c.(1339-1341)GCG>GTG	p.A447V	ZFR2_uc010xhx.1_RNA	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	447						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CACCGGCTGCGCATCAGAGCA	0.617													40	68					0	0	0	0	A	3823275	A	A	3823275	3	1	283	1	0	0	0	0	1	0	0	0	17727	1087	38	1	1527	1	ZFR2	19	3823275	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08		3823275	55305708	100	52613											
SAFB	6294	broad.mit.edu	37	chr19	5667168	5667168	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agggccgggggctgcctcctCcccccaggtttgtgtcccac	3	8	13	17	1	0	0	0	0	0	0	3	0	3	0	7	4	1	2	7	4	0	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr19:5667168C>G	uc002mcf.2	+	18	2499	c.2446C>G	c.(2446-2448)CCC>GCC	p.P816A	SAFB_uc002mcg.2_Missense_Mutation_p.P816A|SAFB_uc002mce.3_Missense_Mutation_p.P815A|SAFB_uc010xir.1_Missense_Mutation_p.P815A|SAFB_uc010xis.1_Missense_Mutation_p.P747A|SAFB_uc010xit.1_Missense_Mutation_p.P658A|SAFB_uc010xiu.1_Missense_Mutation_p.P615A	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	816	Interaction with SAFB2.|Arg-rich.|Gly-rich.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		GCTGCCTCCTCCCCCCAGGTT	0.697													3	22					0	0	0	0	G	5667168	G	G	5667168	3	3	283	1	0	0	0	0	1	0	0	0	13871	855	30	2	2516	2	SAFB	19	5667168	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	1843893	5667168	53461815	101	52614											
ADAMTS10	81794	broad.mit.edu	37	chr19	8656945	8656945	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaggctccgtccacaccctCtgggcgcgacccaaagggga	8	4	12	17	3	1	0	0	0	1	0	3	2	3	1	5	4	0	1	5	4	1	0			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr19:8656945C>G	uc002mkj.1	-	14	1904	c.1630G>C	c.(1630-1632)GAG>CAG	p.E544Q	ADAMTS10_uc002mki.1_Missense_Mutation_p.Q34H|ADAMTS10_uc002mkk.1_Missense_Mutation_p.E176Q	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	544	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TCCACACCCTCTGGGCGCGAC	0.687													3	19					0	0	0	0	G	8656945	G	G	8656945	3	3	283	1	0	0	0	0	1	0	0	0	256	922	32	2	1733	2	ADAMTS10	19	8656945	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	2989777	8656945	50472038	102	52615											
RYR1	6261	broad.mit.edu	37	chr19	38951142	38951142	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacccatcaaggagtatcgaCgggaggggccccgggggcct	9	4	16	12	3	1	0	1	0	0	0	2	3	1	2	4	6	1	1	4	6	3	1	rs142548565		TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr19:38951142C>A	uc002oit.2	+	20	2618	c.2488C>A	c.(2488-2490)CGG>AGG	p.R830R	RYR1_uc002oiu.2_Silent_p.R830R	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	830	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGAGTATCGACGGGAGGGGCC	0.632													16	112					6.72482e-11	7.24946e-11	1	0	A	38951142	A	A	38951142	2	1	283	1	0	0	0	0	0	0	0	1	13833	527	19	3		3	RYR1	19	38951142	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	30294197	38951142	20177841	103	52616											
RYR1	6261	broad.mit.edu	37	chr19	38985060	38985060	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggacttcgtgcagagccccGagctggtgcgggccatgttc	6	8	15	12	3	0	1	0	0	0	1	2	3	0	2	3	3	4	3	3	3	0	2	rs147197176		TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr19:38985060G>A	uc002oit.2	+	39	6473	c.6343G>A	c.(6343-6345)GAG>AAG	p.E2115K	RYR1_uc002oiu.2_Missense_Mutation_p.E2115K|RYR1_uc002oiv.1_5'Flank	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2115	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCAGAGCCCCGAGCTGGTGCG	0.667													3	36					0	0	0	0	A	38985060	A	A	38985060	3	1	283	1	0	0	0	0	1	0	0	0	13833	1059	37	1	6497	1	RYR1	19	38985060	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	33918	38985060	20143923	104	52617											
NAPA	8775	broad.mit.edu	37	chr19	48018174	48018174	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaacagcgccatcgcctcCgcttccttcccggaattgtc	6	9	8	18	4	0	0	0	0	0	0	5	1	3	1	6	1	2	1	6	1	2	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr19:48018174C>T	uc002pha.1	-	1	324	c.24G>A	c.(22-24)GCG>GCA	p.A8A	NAPA_uc002phb.1_Silent_p.A8A|NAPA_uc002phc.1_5'UTR|NAPA_uc002phd.1_Silent_p.A8A|NAPA_uc010elf.1_5'UTR|NAPA_uc010elg.1_RNA|NAPA_uc002phe.2_Silent_p.A8A	NM_003827	NP_003818	P54920	SNAA_HUMAN	N-ethylmaleimide-sensitive factor attachment	8					cellular membrane fusion|intra-Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport	cytosol					0		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000466)|all cancers(93;0.000739)|Epithelial(262;0.0168)|GBM - Glioblastoma multiforme(486;0.049)		CCATCGCCTCCGCTTCCTTCC	0.652													16	18					0	0	0	0	T	48018174	T	T	48018174	2	4	283	1	0	0	0	0	0	0	0	1	10214	639	23	1		1	NAPA	19	48018174	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	9033114	48018174	11110809	105	52618											
MAVS	57506	broad.mit.edu	37	chr20	3844977	3844977	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagcccctggcccgttccAcccccagggcaagccgcttg	5	6	10	20	2	0	0	0	0	0	0	2	0	2	0	8	2	2	3	8	2	1	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr20:3844977A>C	uc002wjw.3	+	6	869	c.700A>C	c.(700-702)ACC>CCC	p.T234P	MAVS_uc002wjx.3_Missense_Mutation_p.T93P|MAVS_uc002wjy.3_5'UTR	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	234	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						GGCCCGTTCCACCCCCAGGGC	0.632													8	73					0	0	0	0	C	3844977	C	C	3844977	3	2	283	1	0	0	0	0	1	0	0	0	9391	159	6	5	718	5	MAVS	20	3844977	Missense_Mutation	SNP	A	TCGA-DQ-5624-01A-01D-1870-08		3844977	59180543	106	52619											
FITM2	128486	broad.mit.edu	37	chr20	42935537	42935537	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtccgtcttcacctcatgcaGcacagacatctcttctacaa	10	11	5	15	1	5	1	2	0	3	1	7	1	6	1	2	0	3	2	2	0	2	3			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr20:42935537G>A	uc002xlr.1	-	2	618	c.517C>T	c.(517-519)CTG>TTG	p.L173L		NM_001080472	NP_001073941	Q8N6M3	FITM2_HUMAN	fat storage-inducing transmembrane protein 2	173	Cytoplasmic (Potential).				cellular triglyceride homeostasis|lipid particle organization|positive regulation of sequestering of triglyceride|regulation of triglyceride biosynthetic process	integral to endoplasmic reticulum membrane				skin(2)	2						ACCTCATGCAGCACAGACATC	0.557													3	38					0	0	0	0	A	42935537	A	A	42935537	2	1	283	1	0	0	0	0	0	0	0	1	5931	962	34	4		4	FITM2	20	42935537	Silent	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	39090560	42935537	20089983	107	52620											
TSHZ2	128553	broad.mit.edu	37	chr20	51871898	51871898	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacagtgagggcgattcttTccgcaaaagtgaaacacctc	12	8	9	12	2	1	2	0	2	1	0	3	3	2	2	3	1	1	1	3	1	3	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr20:51871898T>C	uc002xwo.2	+	2	2857	c.1901T>C	c.(1900-1902)TTC>TCC	p.F634S		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	634					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GGCGATTCTTTCCGCAAAAGT	0.517													20	92					0	0	0	0	C	51871898	C	C	51871898	3	2	283	1	0	0	0	0	1	0	0	0	16691	1783	62	5	1907	5	TSHZ2	20	51871898	Missense_Mutation	SNP	T	TCGA-DQ-5624-01A-01D-1870-08	8936361	51871898	11153622	108	52621											
INPP5J	27124	broad.mit.edu	37	chr22	31529912	31529912	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccccagatctcgctgccttCctcggagttggccagcagca	6	8	10	17	2	1	1	0	0	1	1	4	2	2	2	5	2	3	4	5	2	0	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr22:31529912C>T	uc003aju.3	+	13	2620	c.2528C>T	c.(2527-2529)TCC>TTC	p.S843F	INPP5J_uc003ajv.3_Missense_Mutation_p.S476F|INPP5J_uc003ajs.3_Missense_Mutation_p.S476F|INPP5J_uc011alk.1_Missense_Mutation_p.S776F|INPP5J_uc010gwg.2_Missense_Mutation_p.S408F|INPP5J_uc003ajw.2_3'UTR|INPP5J_uc003ajt.3_Missense_Mutation_p.S475F|INPP5J_uc003ajx.2_Missense_Mutation_p.S208F|INPP5J_uc003ajy.2_Missense_Mutation_p.S182F|INPP5J_uc003ajz.2_Missense_Mutation_p.S283F	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	843	Ser-rich.					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						TCGCTGCCTTCCTCGGAGTTG	0.652													6	12					0	0	0	0	T	31529912	T	T	31529912	3	4	283	1	0	0	0	0	1	0	0	0	7798	855	30	2	1474	2	INPP5J	22	31529912	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08		31529912	19774654	109	52622											
PACSIN2	11252	broad.mit.edu	37	chr22	43308053	43308053	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagctgtcgctggacacttCtactccaacggaatcatcat	11	10	8	12	2	3	0	2	0	1	0	5	3	4	2	1	2	3	2	1	2	4	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr22:43308053C>A	uc010gzg.2	-	2	256	c.34G>T	c.(34-36)GAA>TAA	p.E12*	PACSIN2_uc003bdg.3_Nonsense_Mutation_p.E12*|PACSIN2_uc003bde.3_Nonsense_Mutation_p.E12*|PACSIN2_uc003bdf.3_Nonsense_Mutation_p.E12*	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	12	FCH.				actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				CTGGACACTTCTACTCCAACG	0.468													7	44					8.12818e-05	8.57975e-05	1	0	A	43308053	A	A	43308053	4	1	283	1	0	0	0	0	0	1	0	0	11429	922	32	2	1466	2	PACSIN2	22	43308053	Nonsense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	11778141	43308053	7996513	110	52623											
TTLL8	164714	broad.mit.edu	37	chr22	50479626	50479626	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caaaccccacctgcctgtctCgggctgtggggggctcaaat	7	8	12	14	1	2	0	1	0	1	0	3	0	2	0	4	4	2	2	4	4	2	0			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chr22:50479626C>T	uc011ark.1	-	8	911	c.911G>A	c.(910-912)CGA>CAA	p.R304Q		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CTGCCTGTCTCGGGCTGTGGG	0.567													4	79					0	0	0	0	T	50479626	T	T	50479626	3	4	283	1	0	0	0	0	1	0	0	0	16801	884	31	1	1620	1	TTLL8	22	50479626	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	7171573	50479626	824940	111	52624											
GPR64	10149	broad.mit.edu	37	chrX	19014210	19014210	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	actttccacaacaaagatacCgcctccattgcttcctgaca	12	10	4	15	1	0	2	0	1	0	1	3	2	3	2	5	0	3	1	5	0	3	4	rs142899178	byFrequency	TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chrX:19014210C>T	uc004cyx.2	-	27	2839	c.2675G>A	c.(2674-2676)CGG>CAG	p.R892Q	GPR64_uc004cyy.2_Missense_Mutation_p.R889Q|GPR64_uc004cyz.2_Missense_Mutation_p.R878Q|GPR64_uc004czb.2_Missense_Mutation_p.R892Q|GPR64_uc004czc.2_Missense_Mutation_p.R876Q|GPR64_uc004czd.2_Missense_Mutation_p.R868Q|GPR64_uc004cze.2_Missense_Mutation_p.R862Q|GPR64_uc004czf.2_Missense_Mutation_p.R854Q|GPR64_uc004cza.2_Missense_Mutation_p.R870Q|GPR64_uc004cyw.2_Missense_Mutation_p.R876Q|GPR64_uc010nfj.2_Missense_Mutation_p.R773Q	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	892	Cytoplasmic (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					ACAAAGATACCGCCTCCATTG	0.363													20	186					0	0	0	0	T	19014210	T	T	19014210	3	4	283	1	0	0	0	0	1	0	0	0	6743	652	23	1	390	1	GPR64	23	19014210	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08		19014210	136256350	112	52625											
SAT1	6303	broad.mit.edu	37	chrX	23803921	23803921	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtccagtgaagagggttggaGactgttcaagatcgacaagg	12	8	15	6	1	1	4	1	1	0	3	3	6	2	4	1	3	0	2	1	3	3	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chrX:23803921G>A	uc004dau.2	+	6	658	c.464G>A	c.(463-465)AGA>AAA	p.R155K	SAT1_uc004dav.2_RNA	NM_002970	NP_002961	P21673	SAT1_HUMAN	diamine N-acetyltransferase 1	155	N-acetyltransferase.				angiogenesis|polyamine biosynthetic process	cytosol	diamine N-acetyltransferase activity|protein binding				0					Spermine(DB00127)	GAGGGTTGGAGACTGTTCAAG	0.428													15	67					0	0	0	0	A	23803921	A	A	23803921	3	1	283	1	0	0	0	0	1	0	0	0	13916	942	33	2	486	2	SAT1	23	23803921	Missense_Mutation	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	4789711	23803921	131466639	113	52626											
HUWE1	10075	broad.mit.edu	37	chrX	53674496	53674496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcgaagcggtccaacaggtCcacccagtgatataactcgc	12	7	9	13	3	0	1	0	1	0	0	4	2	2	1	3	2	3	0	3	2	4	2			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chrX:53674496C>T	uc004dsp.2	-	6	568	c.166G>A	c.(166-168)GAC>AAC	p.D56N		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	56					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCCAACAGGTCCACCCAGTGA	0.483													19	229					0	0	0	0	T	53674496	T	T	53674496	3	4	283	1	0	0	0	0	1	0	0	0	7500	855	30	2	13274	2	HUWE1	23	53674496	Missense_Mutation	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	29870575	53674496	101596064	114	52627											
ITIH5L	347365	broad.mit.edu	37	chrX	54784515	54784515	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gataagtagaactttggtttCacaggccttgatttggggga	10	13	13	5	0	1	2	1	1	0	1	1	4	1	3	1	4	1	2	1	4	3	6			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chrX:54784515C>T	uc004dtj.2	-	8	2022	c.1992G>A	c.(1990-1992)GTG>GTA	p.V664V		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	664					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						ACTTTGGTTTCACAGGCCTTG	0.527													11	68					0	0	0	0	T	54784515	T	T	54784515	2	4	283	1	0	0	0	0	0	0	0	1	7947	813	29	2		2	ITIH5L	23	54784515	Silent	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	1110019	54784515	100486045	115	52628											
NOX1	27035	broad.mit.edu	37	chrX	100117563	100117563	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgtcacatactccactgtCtgtgaaaggagaaatgtcag	14	10	9	8	0	3	2	2	1	1	1	4	3	4	2	1	1	1	0	1	1	4	1			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chrX:100117563C>T	uc004egj.2	-	6	696	c.490_splice	c.e6-1	p.T164_splice	uc010nnf.2_Intron|NOX1_uc004egl.3_Splice_Site_p.T164_splice|NOX1_uc010nne.2_Splice_Site_p.T127_splice	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long						angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						ACTCCACTGTCTGTGAAAGGA	0.463													28	239					0	0	0	0	T	100117563	T	T	100117563	5	4	283	1	0	0	0	0	0	0	1	0	10610	927	32	2	1237	2	NOX1	23	100117563	Splice_Site	SNP	C	TCGA-DQ-5624-01A-01D-1870-08	45333048	100117563	55152997	116	52629											
TEX13A	56157	broad.mit.edu	37	chrX	104464968	104464968	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctcccaggataaggatatAttctcaagatagaactcggg	13	11	9	8	1	2	2	1	0	2	2	5	4	2	4	1	3	1	0	1	3	6	6			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chrX:104464968A>T	uc004ema.2	-	2	226	c.114T>A	c.(112-114)AAT>AAA	p.N38K	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.N38K	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	38						intracellular	zinc ion binding			ovary(2)	2						ATAAGGATATATTCTCAAGAT	0.572													6	36					0	0	0	0	T	104464968	T	T	104464968	3	4	283	1	0	0	0	0	1	0	0	0	15842	446	16	5	1125	5	TEX13A	23	104464968	Missense_Mutation	SNP	A	TCGA-DQ-5624-01A-01D-1870-08	4347405	104464968	50805592	117	52630											
KIAA1210	57481	broad.mit.edu	37	chrX	118220567	118220567	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcagatttgggcctgctctgTtgcttatctgcaacgtaaga	8	14	10	9	1	3	2	1	0	2	2	3	2	3	2	1	1	4	5	1	1	3	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chrX:118220567T>C	uc004era.3	-	11	4626	c.4626A>G	c.(4624-4626)CAA>CAG	p.Q1542Q		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1542										ovary(4)|skin(1)	5						GCCTGCTCTGTTGCTTATCTG	0.498													16	94					0	0	0	0	C	118220567	C	C	118220567	2	2	283	1	0	0	0	0	0	0	0	1	8253	1722	60	5		5	KIAA1210	23	118220567	Silent	SNP	T	TCGA-DQ-5624-01A-01D-1870-08	13755599	118220567	37049993	118	52631											
SLITRK2	84631	broad.mit.edu	37	chrX	144904513	144904513	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acccacttagacctcaggggGaataggctaaaagtaatgcc	14	7	10	10	0	1	1	1	0	0	1	1	2	1	2	3	3	1	2	3	3	6	4			TCGA-DQ-5624-01A-01D-1870-08	TCGA-DQ-5624-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	01282192-5bb6-44d6-bbc7-33a42eba416b	9e114c4e-112f-48f3-8420-e7f4170b1221	g.chrX:144904513G>A	uc004fcd.2	+	5	1560	c.570G>A	c.(568-570)GGG>GGA	p.G190G	SLITRK2_uc010nsp.2_Silent_p.G190G|SLITRK2_uc010nso.2_Silent_p.G190G|SLITRK2_uc011mwq.1_Silent_p.G190G|SLITRK2_uc011mwr.1_Silent_p.G190G|SLITRK2_uc011mws.1_Silent_p.G190G|SLITRK2_uc004fcg.2_Silent_p.G190G|SLITRK2_uc011mwt.1_Silent_p.G190G	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	190	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					ACCTCAGGGGGAATAGGCTAA	0.468													11	144					0	0	0	0	A	144904513	A	A	144904513	2	1	283	1	0	0	0	0	0	0	0	1	14807	1161	41	2		2	SLITRK2	23	144904513	Silent	SNP	G	TCGA-DQ-5624-01A-01D-1870-08	26683946	144904513	10366047	119	52632											
C1orf135	79000	broad.mit.edu	37	chr1	26161639	26161639	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagttattggttacatcttGaaaaggagctctagtgttgt	10	15	10	6	0	2	1	0	1	2	0	2	2	2	2	1	2	2	4	1	2	5	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:26161639G>C	uc001bkw.1	-	3	919	c.919C>G	c.(919-921)CAA>GAA	p.Q307E		NM_024037	NP_076942	Q9H7T9	CA135_HUMAN	aurora A-binding protein	307											0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00521)|all_lung(284;0.00764)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.117)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.28e-25)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000787)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		GTTACATCTTGAAAAGGAGCT	0.483													134	144					0	0	0	0	C	26161639	C	C	26161639	3	2	284	1	0	0	0	0	1	0	0	0	2008	1299	45	2	158	2	C1orf135	1	26161639	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		26161639	223088982	1	52633											
TMEM54	113452	broad.mit.edu	37	chr1	33360939	33360939	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttttcccccaccagggcctCagctccagcagctggtgggt	5	9	11	16	0	1	0	1	0	0	0	3	0	3	0	5	3	3	3	5	3	0	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:33360939C>G	uc001bwi.1	-	5	675	c.561G>C	c.(559-561)CTG>CTC	p.L187L	TMEM54_uc001bwj.1_Silent_p.L134L|TMEM54_uc001bwk.1_Silent_p.L167L	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54	187						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACCAGGGCCTCAGCTCCAGCA	0.642													12	9					0	0	0	0	G	33360939	G	G	33360939	2	3	284	1	0	0	0	0	0	0	0	1	16246	813	29	2		2	TMEM54	1	33360939	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	7199300	33360939	215889682	2	52634											
HIVEP3	59269	broad.mit.edu	37	chr1	42047150	42047150	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gggccccaatgggggcctgtCctgccctgggcccttgcctc	2	8	14	17	0	0	0	0	0	0	0	2	0	1	0	7	4	2	0	7	4	1	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:42047150C>T	uc001cgz.3	-	4	4532	c.3319G>A	c.(3319-3321)GAC>AAC	p.D1107N	HIVEP3_uc001cha.3_Missense_Mutation_p.D1107N|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1107					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGGGGCCTGTCCTGCCCTGGG	0.622													48	38					0	0	0	0	T	42047150	T	T	42047150	3	4	284	1	0	0	0	0	1	0	0	0	7227	855	30	2	3925	2	HIVEP3	1	42047150	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	8686211	42047150	207203471	3	52635											
HIVEP3	59269	broad.mit.edu	37	chr1	42048048	42048048	+	Frame_Shift_Del	DEL	C	-	-																															tgctcgagagaatcagatttCtcaaaggagctggtgtgctg																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:42048048delC	uc001cgz.3	-	4	3634	c.2421delG	c.(2419-2421)GAGfs	p.E807fs	HIVEP3_uc001cha.3_Frame_Shift_Del_p.E807fs|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	807	Ser-rich.|No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AATCAGATTTCTCAAAGGAGC	0.562													---	---	---								-	42048048	-	-	42048048	7	5	284	1	0	1	0	1	0	0	0	0	7227	912	32	0	4823	0	HIVEP3	1	42048048	Frame_Shift_Del	DEL	C	TCGA-DQ-5625-01A-01D-1870-08	898	42048048	207202573	4	52636											
ZFYVE9	9372	broad.mit.edu	37	chr1	52704848	52704848	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacccaagcaaccttctaatCttaaacttcaaattccaaag	16	10	3	12	0	3	0	1	0	2	0	4	1	4	0	3	0	3	1	3	0	7	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:52704848C>A	uc001cto.2	+	4	1931	c.1759C>A	c.(1759-1761)CTT>ATT	p.L587I	ZFYVE9_uc001ctn.2_Missense_Mutation_p.L587I|ZFYVE9_uc001ctp.2_Missense_Mutation_p.L587I	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	587					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						ACCTTCTAATCTTAAACTTCA	0.388													35	27					1.22384e-17	1.32174e-17	1	0	A	52704848	A	A	52704848	3	1	284	1	0	0	0	0	1	0	0	0	17738	913	32	2	1765	2	ZFYVE9	1	52704848	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	10656800	52704848	196545773	5	52637											
NBPF10	100132406	broad.mit.edu	37	chr1	145301751	145301751	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcaaagacctcataaaattTatgctgaggaatgagcgaca	16	9	9	7	1	1	3	1	2	0	1	1	5	1	4	1	1	3	2	1	1	5	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:145301751T>A	uc001end.3	+	7	1055	c.1020T>A	c.(1018-1020)TTT>TTA	p.F340L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.F340L|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Missense_Mutation_p.F69L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	340											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TCATAAAATTTATGCTGAGGA	0.527													71	462					0	0	0	0	A	145301751	A	A	145301751	3	1	284	1	0	0	0	0	1	0	0	0	10246	1751	61	5	1046	5	NBPF10	1	145301751	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	92596903	145301751	103948870	6	52638											
LASS2	29956	broad.mit.edu	37	chr1	150940939	150940939	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttgggaggtgcccgcagccGagttttctcctttatgttca	5	14	12	10	2	2	0	1	0	1	0	3	2	2	1	3	2	2	4	3	2	1	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:150940939G>A	uc001evy.2	-	3	610	c.223C>T	c.(223-225)CGG>TGG	p.R75W	LASS2_uc001evz.2_Missense_Mutation_p.R75W|LASS2_uc009wmh.2_5'UTR	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	75	Cytoplasmic (Potential).|Homeobox.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCCCGCAGCCGAGTTTTCTCC	0.562													16	62					0	0	0	0	A	150940939	A	A	150940939	3	1	284	1	0	0	0	0	1	0	0	0	8679	1057	37	1	955	1	LASS2	1	150940939	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	5639188	150940939	98309682	7	52639											
LINGO4	339398	broad.mit.edu	37	chr1	151774265	151774265	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggcatgcccctgacaggcGtagctcctggagccgcacca	8	5	13	15	2	0	1	0	1	0	0	1	3	1	2	5	3	3	4	5	3	1	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:151774265G>A	uc001ezf.1	-	2	1106	c.916C>T	c.(916-918)CGC>TGC	p.R306C		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	306	Extracellular (Potential).|LRR 10.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CCTGACAGGCGTAGCTCCTGG	0.612													10	55					0	0	0	0	A	151774265	A	A	151774265	3	1	284	1	0	0	0	0	1	0	0	0	8859	1145	40	1	869	1	LINGO4	1	151774265	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	833326	151774265	97476356	8	52640											
RPTN	126638	broad.mit.edu	37	chr1	152128885	152128885	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcctgaattggtttttcacaCcgatttaaggcaaagatatg	12	14	8	7	1	1	2	1	1	0	1	2	3	2	2	2	2	0	2	2	2	4	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:152128885C>T	uc001ezs.1	-	3	755	c.690G>A	c.(688-690)CGG>CGA	p.R230R		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	230	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						GTTTTTCACACCGATTTAAGG	0.418													81	173					0	0	0	0	T	152128885	T	T	152128885	2	4	284	1	0	0	0	0	0	0	0	1	13729	494	18	4		4	RPTN	1	152128885	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	354620	152128885	97121736	9	52641											
HRNR	388697	broad.mit.edu	37	chr1	152187530	152187530	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggctggaggagtgccccGaaccggacccatgtcggccg	6	5	16	14	5	0	0	0	0	0	0	1	4	0	3	5	5	2	1	5	5	1	0	rs77317029		TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:152187530G>T	uc001ezt.1	-	3	6651	c.6575C>A	c.(6574-6576)TCG>TAG	p.S2192*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2192	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGTGCCCCGAACCGGACCC	0.632													7	376					3.5997e-14	3.85682e-14	1	0	T	152187530	T	T	152187530	4	4	284	1	0	0	0	0	0	1	0	0	7398	1059	37	3	1981	3	HRNR	1	152187530	Nonsense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	58645	152187530	97063091	10	52642											
HMCN1	83872	broad.mit.edu	37	chr1	185815158	185815158	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttatttttatcttcacagAaattggcccagtgacaatta	12	16	6	7	0	2	2	1	1	1	1	2	2	2	2	1	1	0	1	1	1	5	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:185815158A>T	uc001grq.1	+	2	498	c.269A>T	c.(268-270)GAA>GTA	p.E90V		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	90	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATCTTCACAGAAATTGGCCCA	0.363													6	44					0	0	0	0	T	185815158	T	T	185815158	3	4	284	1	0	0	0	0	1	0	0	0	7259	260	9	5	275	5	HMCN1	1	185815158	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	33627628	185815158	63435463	11	52643											
HMCN1	83872	broad.mit.edu	37	chr1	186084057	186084057	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgctggaacagatcgcaggCgaatagatttacaggtccat	12	9	11	9	2	0	2	0	0	0	2	2	4	1	3	1	3	3	2	1	3	4	3	rs150673369		TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:186084057C>T	uc001grq.1	+	74	11612	c.11383C>T	c.(11383-11385)CGA>TGA	p.R3795*		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3795	Ig-like C2-type 36.				response to stimulus|visual perception	basement membrane	calcium ion binding	p.R3795*(1)		ovary(22)|skin(1)	23						AGATCGCAGGCGAATAGATTT	0.423													7	154					0	0	0	0	T	186084057	T	T	186084057	4	4	284	1	0	0	0	0	0	1	0	0	7259	760	27	1	11677	1	HMCN1	1	186084057	Nonsense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	268899	186084057	63166564	12	52644											
WNT9A	7483	broad.mit.edu	37	chr1	228109319	228109319	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagggccttgtcaccaccCggctctgtgtgttatggccg	4	10	14	13	2	2	0	1	0	1	0	2	0	2	0	4	4	0	3	4	4	1	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:228109319C>T	uc001hri.2	-	4	1086	c.998G>A	c.(997-999)CGG>CAG	p.R333Q		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	333					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				TGTCACCACCCGGCTCTGTGT	0.652													8	38					0	0	0	0	T	228109319	T	T	228109319	3	4	284	1	0	0	0	0	1	0	0	0	17466	652	23	1	103	1	WNT9A	1	228109319	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	42025262	228109319	21141302	13	52645											
RBM34	23029	broad.mit.edu	37	chr1	235324512	235324512	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctggacacttctctttctCttccgtttgctcatcccttc	3	18	4	16	1	3	0	1	0	2	0	9	1	6	1	3	1	1	2	3	1	0	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:235324512C>G	uc001hwn.2	-	1	60	c.30G>C	c.(28-30)AAG>AAC	p.K10N	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Missense_Mutation_p.K10N	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	10						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			TTCTCTTTCTCTTCCGTTTGC	0.622													60	116					0	0	0	0	G	235324512	G	G	235324512	3	3	284	1	0	0	0	0	1	0	0	0	13196	912	32	2	1327	2	RBM34	1	235324512	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	7215193	235324512	13926109	14	52646											
OR2G2	81470	broad.mit.edu	37	chr1	247752273	247752273	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacgaggctgagctttttgtGgctagtatccttttccttat	7	17	9	8	1	0	1	0	1	0	0	2	2	2	1	2	2	2	4	2	2	4	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr1:247752273G>A	uc010pyy.1	+	1	612	c.612G>A	c.(610-612)GTG>GTA	p.V204V		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AGCTTTTTGTGGCTAGTATCC	0.512													19	80					0	0	0	0	A	247752273	A	A	247752273	2	1	284	1	0	0	0	0	0	0	0	1	11052	1335	47	4		4	OR2G2	1	247752273	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	12427761	247752273	1498348	15	52647											
HPCAL1	3241	broad.mit.edu	37	chr2	10560208	10560208	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtgggccttcagcatgtacGacctggacggcaacggctac	9	7	13	12	3	1	0	1	0	0	0	1	2	1	1	2	4	4	4	2	4	3	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:10560208G>A	uc002raj.2	+	3	699	c.325G>A	c.(325-327)GAC>AAC	p.D109N	HPCAL1_uc002rak.2_Missense_Mutation_p.D109N|HPCAL1_uc002ral.2_Missense_Mutation_p.D109N|HPCAL1_uc010exe.2_RNA|HPCAL1_uc010exf.2_Missense_Mutation_p.D109N	NM_002149	NP_002140	P37235	HPCL1_HUMAN	hippocalcin-like 1	109	EF-hand 3.|2 (Potential).						calcium ion binding			pancreas(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)		CAGCATGTACGACCTGGACGG	0.667													13	46					0	0	0	0	A	10560208	A	A	10560208	3	1	284	1	0	0	0	0	1	0	0	0	7369	1058	37	1	327	1	HPCAL1	2	10560208	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		10560208	232639165	16	52648											
BIRC6	57448	broad.mit.edu	37	chr2	32733227	32733227	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgccagcacattaggcctttCacaaattaaattattggggc	12	12	8	9	0	1	0	1	0	0	0	1	0	1	0	2	3	2	1	2	3	5	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:32733227C>G	uc010ezu.2	+	51	10015	c.9881C>G	c.(9880-9882)TCA>TGA	p.S3294*		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3294					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTAGGCCTTTCACAAATTAAA	0.438													4	36					0	0	0	0	G	32733227	G	G	32733227	4	3	284	1	0	0	0	0	0	1	0	0	1441	838	29	2	10083	2	BIRC6	2	32733227	Nonsense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	22173019	32733227	210466146	17	52649											
HEATR5B	54497	broad.mit.edu	37	chr2	37227876	37227876	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgactggtggaggaacctGattatctgcagactttattg	10	13	11	7	0	1	3	0	2	1	1	1	5	1	5	1	3	2	1	1	3	3	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:37227876G>C	uc002rpp.1	-	33	5494	c.5398C>G	c.(5398-5400)CAG>GAG	p.Q1800E	HEATR5B_uc002rpo.1_Missense_Mutation_p.Q113E|HEATR5B_uc010ezy.1_Missense_Mutation_p.Q295E	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1800							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				GGAGGAACCTGATTATCTGCA	0.408													21	54					0	0	0	0	C	37227876	C	C	37227876	3	2	284	1	0	0	0	0	1	0	0	0	7071	1299	45	2	833	2	HEATR5B	2	37227876	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	4494649	37227876	205971497	18	52650											
CEBPZ	10153	broad.mit.edu	37	chr2	37443509	37443509	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atacaaatcgatccaaaaatCtcattagagtgaaatcctgc	17	10	5	9	1	1	2	1	1	1	1	5	3	3	2	2	0	2	0	2	0	6	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:37443509C>G	uc002rpz.2	-	7	2291	c.2261G>C	c.(2260-2262)AGA>ACA	p.R754T		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	754					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				ATCCAAAAATCTCATTAGAGT	0.338													26	85					0	0	0	0	G	37443509	G	G	37443509	3	3	284	1	0	0	0	0	1	0	0	0	3219	913	32	2	943	2	CEBPZ	2	37443509	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	215633	37443509	205755864	19	52651											
KCNG3	170850	broad.mit.edu	37	chr2	42671137	42671137	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatctaaacttgagctcatgAtaacactgcacaaagctatg	15	10	7	9	0	2	2	1	2	1	0	2	3	2	2	0	0	5	3	0	0	5	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:42671137A>G	uc002rsn.2	-	2	1844	c.1248T>C	c.(1246-1248)TAT>TAC	p.Y416Y	KCNG3_uc002rsm.2_Silent_p.Y405Y	NM_133329	NP_579875	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G,	416	Cytoplasmic (Potential).					endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)	1						TGAGCTCATGATAACACTGCA	0.388													16	61					0	0	0	0	G	42671137	G	G	42671137	2	3	284	1	0	0	0	0	0	0	0	1	8068	340	12	5		5	KCNG3	2	42671137	Silent	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	5227628	42671137	200528236	20	52652											
CD8A	925	broad.mit.edu	37	chr2	87013059	87013059	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agggttagacgtatctcgccGaaaggctgggcttgtctccc	7	10	13	11	3	2	1	0	0	2	1	4	2	2	1	2	3	0	4	2	3	3	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:87013059G>A	uc002srt.2	-	6	1581	c.692C>T	c.(691-693)TCG>TTG	p.S231L	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Missense_Mutation_p.S231L|CD8A_uc010ytn.1_Missense_Mutation_p.S272L|CD8A_uc002sru.2_Missense_Mutation_p.S194L	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	231	Cytoplasmic (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						GTATCTCGCCGAAAGGCTGGG	0.512													40	132					0	0	0	0	A	87013059	A	A	87013059	3	1	284	1	0	0	0	0	1	0	0	0	3059	1059	37	1	19	1	CD8A	2	87013059	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	44341922	87013059	156186314	21	52653											
LRP1B	53353	broad.mit.edu	37	chr2	141356336	141356336	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tactgaccaccacttgagcaTttttcccagtcagagtagat	11	12	7	11	0	1	4	1	2	0	2	2	4	2	4	3	0	2	2	3	0	2	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:141356336T>A	uc002tvj.1	-	43	8030	c.7058A>T	c.(7057-7059)AAT>ATT	p.N2353I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2353	Extracellular (Potential).|LDL-receptor class B 25.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CACTTGAGCATTTTTCCCAGT	0.368										TSP Lung(27;0.18)			9	31					0	0	0	0	A	141356336	A	A	141356336	3	1	284	1	0	0	0	0	1	0	0	0	9005	1493	52	5	6937	5	LRP1B	2	141356336	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	54343277	141356336	101843037	22	52654											
NMI	9111	broad.mit.edu	37	chr2	152135393	152135393	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcctttttgtatctcataagGaactttcgagctcacttgaa	10	16	6	9	1	2	1	2	1	1	0	5	3	3	2	1	1	2	2	1	1	4	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:152135393G>A	uc002txi.2	-	4	619	c.289C>T	c.(289-291)CCT>TCT	p.P97S	NMI_uc010zbx.1_Missense_Mutation_p.P97S|NMI_uc002txj.2_Missense_Mutation_p.P65S	NM_004688	NP_004679	Q13287	NMI_HUMAN	N-myc and STAT interactor	97					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity				0				BRCA - Breast invasive adenocarcinoma(221;0.0571)		ATCTCATAAGGAACTTTCGAG	0.343													5	26					0	0	0	0	A	152135393	A	A	152135393	3	1	284	1	0	0	0	0	1	0	0	0	10551	1174	41	2	654	2	NMI	2	152135393	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	10779057	152135393	91063980	23	52655											
IFIH1	64135	broad.mit.edu	37	chr2	163167287	163167287	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acaaatacctgcattgctttCtgagcaatcagagcctgtta	12	12	7	10	0	2	2	1	1	1	1	2	2	2	2	2	0	5	4	2	0	4	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:163167287C>G	uc002uce.2	-	2	832	c.610G>C	c.(610-612)GAA>CAA	p.E204Q	IFIH1_uc002ucf.2_Missense_Mutation_p.E204Q	NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	204					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						GCATTGCTTTCTGAGCAATCA	0.373													12	24					0	0	0	0	G	163167287	G	G	163167287	3	3	284	1	0	0	0	0	1	0	0	0	7559	922	32	2	2527	2	IFIH1	2	163167287	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	11031894	163167287	80032086	24	52656											
WIPF1	7456	broad.mit.edu	37	chr2	175446073	175446073	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttctgtcattggtgaccGtcttctttagtttcttccct	4	19	6	12	1	5	1	1	1	4	0	6	1	6	1	2	1	0	1	2	1	1	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:175446073G>A	uc002uiy.2	-	4	478	c.146C>T	c.(145-147)ACG>ATG	p.T49M	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.T49M|WIPF1_uc010fqt.1_Missense_Mutation_p.T49M|WIPF1_uc002ujc.1_Missense_Mutation_p.T49M|WIPF1_uc002uiz.2_Missense_Mutation_p.T49M|WIPF1_uc002ujb.1_Missense_Mutation_p.T49M|WIPF1_uc010zep.1_Missense_Mutation_p.T49M	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	49	WH2.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						ATTGGTGACCGTCTTCTTTAG	0.433													65	238					0	0	0	0	A	175446073	A	A	175446073	3	1	284	1	0	0	0	0	1	0	0	0	17435	1145	40	1	1389	1	WIPF1	2	175446073	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	12278786	175446073	67753300	25	52657											
TTN	7273	broad.mit.edu	37	chr2	179418418	179418418	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttcctctccttgtcttatctCgacaacatacccagtaacag	10	13	4	14	1	3	0	0	0	3	0	6	1	4	0	3	0	3	1	3	0	4	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:179418418C>G	uc010zfg.1	-	283	81834	c.81610G>C	c.(81610-81612)GAG>CAG	p.E27204Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E20899Q|TTN_uc010zfi.1_Missense_Mutation_p.E20832Q|TTN_uc010zfj.1_Missense_Mutation_p.E20707Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28131							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTCTTATCTCGACAACATAC	0.463													11	62					0	0	0	0	G	179418418	G	G	179418418	3	3	284	1	0	0	0	0	1	0	0	0	16803	893	31	3	18781	3	TTN	2	179418418	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	3972345	179418418	63780955	26	52658											
ITGA4	3676	broad.mit.edu	37	chr2	182347350	182347350	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccatcagagaggaaggaaGagtgtttgtgtacatcaact	14	9	11	7	0	2	2	2	0	0	2	2	5	2	4	1	2	2	2	1	2	4	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:182347350G>T	uc002unu.2	+	9	1776	c.1013G>T	c.(1012-1014)AGA>ATA	p.R338I	ITGA4_uc010zfl.1_Missense_Mutation_p.R338I	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	338	FG-GAP 5.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GAGGAAGGAAGAGTGTTTGTG	0.473													34	130					1.36239e-07	1.42576e-07	1	0	T	182347350	T	T	182347350	3	4	284	1	0	0	0	0	1	0	0	0	7917	942	33	2	1047	2	ITGA4	2	182347350	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	2928932	182347350	60852023	27	52659											
SPEG	10290	broad.mit.edu	37	chr2	220334043	220334043	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctgccctaccccaccatCagctggttccacaatggcca	8	7	8	18	0	1	0	1	0	0	0	2	0	2	0	7	3	3	2	7	3	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:220334043C>T	uc010fwg.2	+	13	3657	c.3657C>T	c.(3655-3657)ATC>ATT	p.I1219I		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1219	Ig-like 6.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ACCCCACCATCAGCTGGTTCC	0.642													4	23					0	0	0	0	T	220334043	T	T	220334043	2	4	284	1	0	0	0	0	0	0	0	1	15102	816	29	2		2	SPEG	2	220334043	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	37986693	220334043	22865330	28	52660											
SPEG	10290	broad.mit.edu	37	chr2	220336980	220336980	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggccctccagatggcgccccGcaggtggtggctgtgacggg	4	6	18	13	3	0	2	0	1	0	1	1	2	1	2	4	6	0	2	4	6	0	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:220336980G>A	uc010fwg.2	+	15	3867	c.3867G>A	c.(3865-3867)CCG>CCA	p.P1289P		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1289	Fibronectin type-III 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ATGGCGCCCCGCAGGTGGTGG	0.647													12	62					0	0	0	0	A	220336980	A	A	220336980	2	1	284	1	0	0	0	0	0	0	0	1	15102	1074	38	1		1	SPEG	2	220336980	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	2937	220336980	22862393	29	52661											
UGT1A8	54576	broad.mit.edu	37	chr2	234526661	234526661	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaatggaaagcacaagtacGaagtttgttttctctatttc	12	15	7	7	1	2	0	1	0	1	0	4	2	2	1	0	1	2	4	0	1	6	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:234526661G>A	uc002vup.2	+	1	371	c.308G>A	c.(307-309)CGA>CAA	p.R103Q	UGT1A8_uc010zmv.1_Missense_Mutation_p.R103Q	NM_019076	NP_061949	Q9HAW9	UD18_HUMAN	UDP glycosyltransferase 1 family, polypeptide A8	103					drug metabolic process|fatty acid metabolic process|flavone metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme inhibitor activity|fatty acid binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|steroid binding			ovary(2)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		GCACAAGTACGAAGTTTGTTT	0.383													35	94					0	0	0	0	A	234526661	A	A	234526661	3	1	284	1	0	0	0	0	1	0	0	0	17019	1058	37	1	310	1	UGT1A8	2	234526661	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	14189681	234526661	8672712	30	52662											
SH3BP4	23677	broad.mit.edu	37	chr2	235949874	235949874	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgacaaaaaagtaccaggcaGaatgtacagtaataaccctt	18	8	7	8	0	0	2	0	1	0	1	0	2	0	2	2	1	3	4	2	1	8	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:235949874G>A	uc002vvp.2	+	4	854	c.461G>A	c.(460-462)AGA>AAA	p.R154K	SH3BP4_uc010fym.2_Missense_Mutation_p.R154K|SH3BP4_uc002vvq.2_Missense_Mutation_p.R154K	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	154					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GTACCAGGCAGAATGTACAGT	0.512													16	68					0	0	0	0	A	235949874	A	A	235949874	3	1	284	1	0	0	0	0	1	0	0	0	14311	942	33	2	467	2	SH3BP4	2	235949874	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	1423213	235949874	7249499	31	52663											
ANKMY1	51281	broad.mit.edu	37	chr2	241463486	241463486	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttcgtctcagcactgcacaGactgccccggtctgtgtttc	5	13	9	14	2	2	1	1	0	2	1	5	1	2	1	2	1	3	3	2	1	0	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:241463486G>C	uc002vyz.1	-	7	1610	c.1381C>G	c.(1381-1383)CTG>GTG	p.L461V	ANKMY1_uc002vza.1_Missense_Mutation_p.L320V|ANKMY1_uc010fzd.1_Missense_Mutation_p.L550V|ANKMY1_uc002vzb.1_Intron|ANKMY1_uc002vzc.1_Missense_Mutation_p.L320V|ANKMY1_uc002vzd.1_Missense_Mutation_p.L320V|ANKMY1_uc010fze.1_Missense_Mutation_p.L130V|ANKMY1_uc002vze.2_Missense_Mutation_p.L222V	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	461							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GCACTGCACAGACTGCCCCGG	0.597													16	69					0	0	0	0	C	241463486	C	C	241463486	3	2	284	1	0	0	0	0	1	0	0	0	634	933	33	2	1488	2	ANKMY1	2	241463486	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	5513612	241463486	1735887	32	52664											
KIF1A	547	broad.mit.edu	37	chr2	241702193	241702193	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggtagtacctggagtccaTctgcttctgcagagcctcca	7	10	11	13	1	2	1	0	0	2	1	4	2	4	2	4	2	4	4	4	2	2	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr2:241702193T>A	uc002vzy.2	-	22	2178	c.2032A>T	c.(2032-2034)ATG>TTG	p.M678L	KIF1A_uc010fzk.2_Missense_Mutation_p.M687L|KIF1A_uc002vzz.1_Missense_Mutation_p.M687L	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	678	Potential.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CTGGAGTCCATCTGCTTCTGC	0.622													3	10					0	0	0	0	A	241702193	A	A	241702193	3	1	284	1	0	0	0	0	1	0	0	0	8322	1435	50	5	3144	5	KIF1A	2	241702193	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	238707	241702193	1497180	33	52665											
RAF1	5894	broad.mit.edu	37	chr3	12626379	12626379	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggcctctcttcctttactttCttcacacagtcagctaccag	7	14	5	15	0	4	0	2	0	2	0	6	0	5	0	3	1	3	1	3	1	2	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:12626379C>T	uc003bxf.3	-	16	2185	c.1770G>A	c.(1768-1770)AAG>AAA	p.K590K	RAF1_uc011aut.1_Silent_p.K375K|RAF1_uc011auu.1_Silent_p.K508K	NM_002880	NP_002871	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog	590	Protein kinase.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)	CCTTTACTTTCTTCACACAGT	0.463			T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				24	71					0	0	0	0	T	12626379	T	T	12626379	2	4	284	1	0	0	0	0	0	0	0	1	13067	912	32	2		2	RAF1	3	12626379	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08		12626379	185396051	34	52666											
NUP210	23225	broad.mit.edu	37	chr3	13368824	13368824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggcaggggcatgaagtccGagaggcccgggtgctctgcg	7	5	18	11	3	1	2	0	1	1	1	2	3	2	2	2	5	2	3	2	5	1	0	rs147955019	byFrequency	TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:13368824G>A	uc003bxv.1	-	32	4483	c.4400C>T	c.(4399-4401)TCG>TTG	p.S1467L		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1467	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CATGAAGTCCGAGAGGCCCGG	0.652													7	26					0	0	0	0	A	13368824	A	A	13368824	3	1	284	1	0	0	0	0	1	0	0	0	10814	1059	37	1	1299	1	NUP210	3	13368824	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	742445	13368824	184653606	35	52667											
ZNF860	344787	broad.mit.edu	37	chr3	32030581	32030581	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctaaagactcatgttacgtGaggaagcagctcagaagagg	14	8	12	7	1	3	4	2	1	1	3	3	5	3	5	0	2	3	3	0	2	5	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:32030581G>A	uc011axg.1	+	2	559	c.10G>A	c.(10-12)GAG>AAG	p.E4K		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATGTTACGTGAGGAAGCAGC	0.408													14	72					0	0	0	0	A	32030581	A	A	32030581	3	1	284	1	0	0	0	0	1	0	0	0	18261	1291	45	2	12	2	ZNF860	3	32030581	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	18661757	32030581	165991849	36	52668											
CNOT10	25904	broad.mit.edu	37	chr3	32758664	32758665	+	Frame_Shift_Ins	INS	-	T	T																															gtacaaagtacgagcttataINStccaaatgaagtctctgaaa																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:32758664_32758665insT	uc003cfc.1	+	7	934_935	c.679_680insT	c.(679-681)ATCfs	p.I227fs	CNOT10_uc011axi.1_5'UTR|CNOT10_uc003cfd.1_Frame_Shift_Ins_p.I226fs|CNOT10_uc003cfe.1_Frame_Shift_Ins_p.I227fs|CNOT10_uc010hfv.1_RNA|CNOT10_uc011axj.1_Frame_Shift_Ins_p.I287fs|CNOT10_uc010hfw.1_5'UTR	NM_015442	NP_056257	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	227					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			central_nervous_system(1)|skin(1)	2						ACGAGCTTATATCCAAATGAAG	0.327													---	---	---								T	32758665	T	T	32758664	7	5	284	1	0	1	1	0	0	0	0	0	3633	449	16	0	705	0	CNOT10	3	32758664	Frame_Shift_Ins	INS	-	TCGA-DQ-5625-01A-01D-1870-08	728083	32758664	165263766	37	52669											
CSPG5	10675	broad.mit.edu	37	chr3	47618627	47618627	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcactagaagctcattttCatcttctaggtctccacctc	8	13	7	13	0	5	1	2	0	3	1	7	1	5	1	2	2	1	2	2	2	3	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:47618627C>T	uc003crp.3	-	2	1065	c.889G>A	c.(889-891)GAA>AAA	p.E297K	CSPG5_uc003crn.2_Missense_Mutation_p.E159K|CSPG5_uc003cro.3_Missense_Mutation_p.E297K|CSPG5_uc011bbb.1_Missense_Mutation_p.E159K	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	297	Interaction with TNC and TNR (By similarity).|Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		AGCTCATTTTCATCTTCTAGG	0.413													7	25					0	0	0	0	T	47618627	T	T	47618627	3	4	284	1	0	0	0	0	1	0	0	0	3978	835	29	2	746	2	CSPG5	3	47618627	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	14859963	47618627	150403803	38	52670											
CSPG5	10675	broad.mit.edu	37	chr3	47618876	47618876	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	accctcaccatccagtccttCgaagtagtcgatgtcaatga	11	10	7	13	2	2	1	2	1	0	0	6	3	4	1	4	0	0	1	4	0	3	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:47618876C>T	uc003crp.3	-	2	816	c.640G>A	c.(640-642)GAA>AAA	p.E214K	CSPG5_uc003crn.2_Missense_Mutation_p.E76K|CSPG5_uc003cro.3_Missense_Mutation_p.E214K|CSPG5_uc011bbb.1_Missense_Mutation_p.E76K	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	214	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCCAGTCCTTCGAAGTAGTCG	0.592													13	41					0	0	0	0	T	47618876	T	T	47618876	3	4	284	1	0	0	0	0	1	0	0	0	3978	893	31	1	995	1	CSPG5	3	47618876	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	249	47618876	150403554	39	52671											
DHX30	22907	broad.mit.edu	37	chr3	47889747	47889747	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggcgggccgctgccagtcCggctttgcctaccacttgtt	3	10	13	15	4	0	0	0	0	0	0	1	0	1	0	5	3	3	3	5	3	1	4	rs147501030		TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:47889747C>T	uc003cru.2	+	15	2790	c.2364C>T	c.(2362-2364)TCC>TCT	p.S788S	DHX30_uc003crt.2_Silent_p.S749S|MIR1226_hsa-mir-1226|MI0006313_5'Flank	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	788	Helicase C-terminal.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		gcTGCCAGTCCGGCTTTGCCT	0.502													12	38					0	0	0	0	T	47889747	T	T	47889747	2	4	284	1	0	0	0	0	0	0	0	1	4526	639	23	1		1	DHX30	3	47889747	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	270871	47889747	150132683	40	52672											
RHOA	387	broad.mit.edu	37	chr3	49412905	49412905	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatatctgccacatagttctCaaacactgtgggcacataca	13	10	7	11	0	2	0	1	0	2	0	3	1	2	0	1	1	3	2	1	1	4	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:49412905C>G	uc003cwu.2	-	2	394	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	40	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATAGTTCTCAAACACTGTG	0.438													39	135					0	0	0	0	G	49412905	G	G	49412905	3	3	284	1	0	0	0	0	1	0	0	0	13396	835	29	2	479	2	RHOA	3	49412905	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	1523158	49412905	148609525	41	52673											
STAB1	23166	broad.mit.edu	37	chr3	52539121	52539121	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccacgtggtcactggcctgCggtggcaggccccctctggg	3	8	15	15	2	2	0	1	0	1	0	3	0	3	0	4	6	1	1	4	6	0	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:52539121C>A	uc003dej.2	+	13	1554	c.1480C>A	c.(1480-1482)CGG>AGG	p.R494R	STAB1_uc003dei.1_Silent_p.R494R	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	494	Extracellular (Potential).|FAS1 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CACTGGCCTGCGGTGGCAGGC	0.597													23	94					9.04412e-07	9.39197e-07	1	0	A	52539121	A	A	52539121	2	1	284	1	0	0	0	0	0	0	0	1	15303	759	27	3		3	STAB1	3	52539121	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	3126216	52539121	145483309	42	52674											
FAM116A	201627	broad.mit.edu	37	chr3	57619070	57619070	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagcctcagaaggacgtttCtgttgtacacccttaaaaga	12	11	9	9	1	2	3	1	1	1	2	2	4	2	4	2	1	2	3	2	1	4	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:57619070C>G	uc003dja.2	-	15	1346	c.1275G>C	c.(1273-1275)CAG>CAC	p.Q425H		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	425										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		AAGGACGTTTCTGTTGTACAC	0.299													16	53					0	0	0	0	G	57619070	G	G	57619070	3	3	284	1	0	0	0	0	1	0	0	0	5435	912	32	2	575	2	FAM116A	3	57619070	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	5079949	57619070	140403360	43	52675											
ADAMTS9	56999	broad.mit.edu	37	chr3	64526789	64526789	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgattatctgcatgctggTcaggtctattctgattttct	7	18	8	8	0	5	2	1	2	4	0	5	2	5	2	0	2	2	2	0	2	2	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:64526789T>C	uc003dmg.2	-	36	5535	c.5503A>G	c.(5503-5505)ACC>GCC	p.T1835A	ADAMTS9_uc011bfo.1_Missense_Mutation_p.T1807A|ADAMTS9_uc011bfp.1_Missense_Mutation_p.T746A	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1835	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TGCATGCTGGTCAGGTCTATT	0.493													18	52					0	0	0	0	C	64526789	C	C	64526789	3	2	284	1	0	0	0	0	1	0	0	0	273	1667	58	5	320	5	ADAMTS9	3	64526789	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	6907719	64526789	133495641	44	52676											
SLC9A10	285335	broad.mit.edu	37	chr3	111886130	111886130	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttctaatattccttctgAatgttttcatgttaatcgga	10	19	5	7	1	3	1	1	1	2	0	5	2	4	2	1	1	0	2	1	1	4	8			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:111886130A>T	uc003dyu.2	-	26	3524	c.3302T>A	c.(3301-3303)TTC>TAC	p.F1101Y	SLC9A10_uc011bhu.1_Missense_Mutation_p.F364Y|SLC9A10_uc010hqc.2_Missense_Mutation_p.F1053Y	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	1101					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						ATTCCTTCTGAATGTTTTCAT	0.303													4	22					0	0	0	0	T	111886130	T	T	111886130	3	4	284	1	0	0	0	0	1	0	0	0	14774	246	9	5	247	5	SLC9A10	3	111886130	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	47359341	111886130	86136300	45	52677											
UMPS	7372	broad.mit.edu	37	chr3	124462850	124462850	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgtaggtcgtggcataatCtcagcagctgatcgtctgga	9	12	12	8	2	2	1	1	1	2	0	5	2	2	2	0	3	2	4	0	3	2	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:124462850C>T	uc003ehl.3	+	6	1468	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_Silent_p.I276I|UMPS_uc011bkb.1_Silent_p.I362I|UMPS_uc011bkc.1_Silent_p.I276I|UMPS_uc003ehn.3_Silent_p.I276I|UMPS_uc011bkd.1_Silent_p.I179I	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	454	OMPdecase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)		GTGGCATAATCTCAGCAGCTG	0.433													12	22					0	0	0	0	T	124462850	T	T	124462850	2	4	284	1	0	0	0	0	0	0	0	1	17049	903	32	2		2	UMPS	3	124462850	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	12576720	124462850	73559580	46	52678											
MUC13	56667	broad.mit.edu	37	chr3	124641076	124641076	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcactatgcaagtcttgatAggccatggaatgtttctctt	9	16	8	8	0	3	1	1	1	2	0	4	2	3	2	1	2	1	2	1	2	4	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:124641076A>G	uc003ehq.1	-	4	733	c.709T>C	c.(709-711)TAT>CAT	p.Y237H		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	237	SEA.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						AAGTCTTGATAGGCCATGGAA	0.373													7	36					0	0	0	0	G	124641076	G	G	124641076	3	3	284	1	0	0	0	0	1	0	0	0	10024	420	15	5	858	5	MUC13	3	124641076	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	178226	124641076	73381354	47	52679											
PIK3R4	30849	broad.mit.edu	37	chr3	130452474	130452474	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgtattccggataaatattGatatcattacgaggaacctc	14	13	7	7	2	1	1	1	1	0	0	3	4	2	3	2	2	2	1	2	2	7	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:130452474G>C	uc003enj.2	-	4	1949	c.1368C>G	c.(1366-1368)ATC>ATG	p.I456M		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	456					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						GATAAATATTGATATCATTAC	0.448													12	40					0	0	0	0	C	130452474	C	C	130452474	3	2	284	1	0	0	0	0	1	0	0	0	11976	1280	45	2	2776	2	PIK3R4	3	130452474	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	5811398	130452474	67569956	48	52680											
IGSF10	285313	broad.mit.edu	37	chr3	151155070	151155070	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactggcttctggccaatttCtaatatgactaatttctcaa	12	15	5	9	0	3	1	1	1	3	0	4	1	3	1	1	2	1	1	1	2	6	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:151155070C>A	uc011bod.1	-	6	7279	c.7279G>T	c.(7279-7281)GAA>TAA	p.E2427*	IGSF10_uc011bob.1_Nonsense_Mutation_p.E454*|IGSF10_uc011boc.1_Nonsense_Mutation_p.E406*	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2427	Ig-like C2-type 10.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGGCCAATTTCTAATATGACT	0.403													15	76					3.27435e-08	3.46696e-08	1	0	A	151155070	A	A	151155070	4	1	284	1	0	0	0	0	0	1	0	0	7636	922	32	2	596	2	IGSF10	3	151155070	Nonsense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	20702596	151155070	46867360	49	52681											
MME	4311	broad.mit.edu	37	chr3	154832894	154832894	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cattcccgagaccagctcccGttacggcaactttgacattt	9	11	7	14	3	0	2	0	1	0	1	2	3	2	2	3	1	3	3	3	1	2	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:154832894G>A	uc010hvr.1	+	4	519	c.308G>A	c.(307-309)CGT>CAT	p.R103H	MME_uc003fab.1_Missense_Mutation_p.R103H|MME_uc003fac.1_Missense_Mutation_p.R103H|MME_uc003fad.1_Missense_Mutation_p.R103H|MME_uc003fae.1_Missense_Mutation_p.R103H	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	103	Extracellular (Potential).	Substrate carboxyl (By similarity).			cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding	p.R103L(1)		ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	ACCAGCTCCCGTTACGGCAAC	0.413													20	83					0	0	0	0	A	154832894	A	A	154832894	3	1	284	1	0	0	0	0	1	0	0	0	9698	1145	40	1	318	1	MME	3	154832894	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	3677824	154832894	43189536	50	52682											
SEC62	7095	broad.mit.edu	37	chr3	169703609	169703609	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctaggtgtatgtatggatctAtgacccagttcactttaaaa	12	14	8	7	0	2	1	1	1	1	0	2	2	2	2	1	2	0	3	1	2	6	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:169703609A>G	uc003fgg.2	+	6	597	c.566A>G	c.(565-567)TAT>TGT	p.Y189C	SEC62_uc003fgh.2_Missense_Mutation_p.Y189C	NM_003262	NP_003253	Q99442	SEC62_HUMAN	translocation protein 1	189	Cytoplasmic (Potential).				cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			ovary(1)	1						GTATGGATCTATGACCCAGTT	0.308													12	48					0	0	0	0	G	169703609	G	G	169703609	3	3	284	1	0	0	0	0	1	0	0	0	14069	449	16	5	588	5	SEC62	3	169703609	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	14870715	169703609	28318821	51	52683											
MUC4	4585	broad.mit.edu	37	chr3	195501148	195501148	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgaactccaggtccccggcGcctgccccataggggaagag	9	4	13	15	3	0	1	0	0	0	1	2	3	2	2	6	4	2	0	6	4	3	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr3:195501148G>A	uc011bto.1	-	5	13048	c.12588C>T	c.(12586-12588)GGC>GGT	p.G4196G	MUC4_uc003fuz.2_Missense_Mutation_p.A4V|MUC4_uc003fva.2_5'UTR|MUC4_uc003fvb.2_5'UTR|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_5'UTR|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_5'UTR|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_5'UTR|MUC4_uc011bti.1_5'UTR|MUC4_uc011btj.1_Silent_p.G65G|MUC4_uc011btk.1_5'UTR|MUC4_uc011btl.1_5'UTR|MUC4_uc011btm.1_Silent_p.G65G|MUC4_uc011btn.1_5'UTR|MUC4_uc003fvo.2_Silent_p.G88G|MUC4_uc003fvp.2_Silent_p.G37G|MUC4_uc010hzu.1_Silent_p.G936G	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1081					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGTCCCCGGCGCCTGCCCCAT	0.627													26	32					0	0	0	0	A	195501148	A	A	195501148	2	1	284	1	0	0	0	0	0	0	0	1	10031	1074	38	1		1	MUC4	3	195501148	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	25797539	195501148	2521282	52	52684											
PACRGL	133015	broad.mit.edu	37	chr4	20711361	20711361	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggaatgtcctcctgaaagtCtttcatttgatccacttctt	8	16	7	10	0	3	2	1	2	2	0	6	3	6	3	3	1	0	0	3	1	2	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr4:20711361C>G	uc010iek.2	+	5	722	c.331C>G	c.(331-333)CTT>GTT	p.L111V	PACRGL_uc003gpu.2_RNA|PACRGL_uc010iei.1_Missense_Mutation_p.L159V|PACRGL_uc003gpz.2_Missense_Mutation_p.L111V|PACRGL_uc011bxm.1_Intron|PACRGL_uc003gqa.2_Intron|PACRGL_uc003gpx.3_RNA|PACRGL_uc003gpv.2_Missense_Mutation_p.L111V|PACRGL_uc003gpw.2_RNA|PACRGL_uc010iej.1_RNA|PACRGL_uc011bxn.1_Intron|PACRGL_uc003gpy.2_Intron	NM_145048	NP_659485	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like isoform 1	111							binding				0						TCCTGAAAGTCTTTCATTTGA	0.289													16	82					0	0	0	0	G	20711361	G	G	20711361	3	3	284	1	0	0	0	0	1	0	0	0	11425	913	32	2	345	2	PACRGL	4	20711361	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08		20711361	170442915	53	52685											
PCDH7	5099	broad.mit.edu	37	chr4	30724333	30724333	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccctcaaggacggggtggCcaacgtggccgaggacgttc	7	5	15	14	4	1	0	1	0	0	0	2	3	1	2	4	6	1	1	4	6	2	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr4:30724333C>T	uc003gsk.1	+	1	2297	c.1289C>T	c.(1288-1290)GCC>GTC	p.A430V	PCDH7_uc011bxw.1_Missense_Mutation_p.A383V|PCDH7_uc011bxx.1_Missense_Mutation_p.A430V	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	430	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GACGGGGTGGCCAACGTGGCC	0.617													3	24					0	0	0	0	T	30724333	T	T	30724333	3	4	284	1	0	0	0	0	1	0	0	0	11570	739	26	4	1291	4	PCDH7	4	30724333	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	10012972	30724333	160429943	54	52686											
EPHA5	2044	broad.mit.edu	37	chr4	66197845	66197845	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttctgccaataaattagataCtctaaaacacataaaacata	20	11	2	8	0	2	1	0	0	2	1	2	1	2	1	1	0	4	0	1	0	10	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr4:66197845C>T	uc003hcy.2	-	17	3047	c.2854G>A	c.(2854-2856)GTA>ATA	p.V952I	EPHA5_uc003hcx.2_Missense_Mutation_p.V884I|EPHA5_uc003hcz.2_Missense_Mutation_p.V930I|EPHA5_uc011cah.1_Missense_Mutation_p.V953I|EPHA5_uc011cai.1_Missense_Mutation_p.V931I|EPHA5_uc003hda.2_Missense_Mutation_p.V953I	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	952	Cytoplasmic (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AAATTAGATACTCTAAAACAC	0.333										TSP Lung(17;0.13)			3	24					0	0	0	0	T	66197845	T	T	66197845	3	4	284	1	0	0	0	0	1	0	0	0	5194	579	20	4	267	4	EPHA5	4	66197845	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	35473512	66197845	124956431	55	52687											
CXCL2	2920	broad.mit.edu	37	chr4	74964583	74964583	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actttggatgttcttgaggtGaattccctgcagggtctgca	7	14	12	8	0	2	2	0	2	2	0	3	3	3	3	1	3	2	3	1	3	1	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr4:74964583G>A	uc003hhm.3	-	2	317	c.157C>T	c.(157-159)CAC>TAC	p.H53Y		NM_002089	NP_002080	P19875	CXCL2_HUMAN	chemokine (C-X-C motif) ligand 2	53					chemotaxis|immune response|inflammatory response|response to molecule of bacterial origin	extracellular space|soluble fraction	chemokine activity				0	Breast(15;0.00612)		all cancers(17;0.00317)|Lung(101;0.196)			TTCTTGAGGTGAATTCCCTGC	0.617													31	142					0	0	0	0	A	74964583	A	A	74964583	3	1	284	1	0	0	0	0	1	0	0	0	4102	1290	45	2	178	2	CXCL2	4	74964583	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	8766738	74964583	116189693	56	52688											
SPARCL1	8404	broad.mit.edu	37	chr4	88415749	88415749	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttagtactgatgatttttcaGccttaaaagaaaaaaaagtt	17	14	6	4	0	1	3	1	2	0	1	1	3	1	3	1	0	2	2	1	0	8	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr4:88415749G>A	uc010ikm.2	-	5	775	c.203C>T	c.(202-204)GCT>GTT	p.A68V	SPARCL1_uc011cdc.1_Intron|SPARCL1_uc003hqs.3_Missense_Mutation_p.A68V|SPARCL1_uc011cdd.1_5'UTR|SPARCL1_uc003hqt.2_Missense_Mutation_p.A68V	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	68					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TGATTTTTCAGCCTTAAAAGA	0.338													3	36					0	0	0	0	A	88415749	A	A	88415749	3	1	284	1	0	0	0	0	1	0	0	0	15062	985	34	4	1823	4	SPARCL1	4	88415749	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	13451166	88415749	102738527	57	52689											
COL25A1	84570	broad.mit.edu	37	chr4	109783686	109783686	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttgggcctctagttcctgAttcaccttgtttcccctatt	4	18	6	13	0	2	1	1	1	1	0	4	1	4	1	5	1	0	2	5	1	2	8			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr4:109783686A>C	uc003hze.1	-	21	1699	c.1168T>G	c.(1168-1170)TCA>GCA	p.S390A	COL25A1_uc003hzg.2_Missense_Mutation_p.S390A|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Intron	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	390	Extracellular (Potential).|Collagen-like 5.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CTAGTTCCTGATTCACCTTGT	0.373													110	221					0	0	0	0	C	109783686	C	C	109783686	3	2	284	1	0	0	0	0	1	0	0	0	3699	333	12	5	948	5	COL25A1	4	109783686	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	21367937	109783686	81370590	58	52690											
CCNA2	890	broad.mit.edu	37	chr4	122740557	122740557	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcaactttgcagtttgcAggctgctgatgcagaaagta	10	13	10	8	0	1	2	1	1	0	1	1	2	1	2	0	1	5	7	0	1	3	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr4:122740557A>T	uc003iec.3	-	5	1277	c.972T>A	c.(970-972)CCT>CCA	p.P324P		NM_001237	NP_001228	P20248	CCNA2_HUMAN	cyclin A	324					cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			ovary(1)	1						TGCAGTTTGCAGGCTGCTGAT	0.373													3	52					0	0	0	0	T	122740557	T	T	122740557	2	4	284	1	0	0	0	0	0	0	0	1	2925	175	7	5		5	CCNA2	4	122740557	Silent	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	12956871	122740557	68413719	59	52691											
CLGN	1047	broad.mit.edu	37	chr4	141320051	141320051	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcaggaatttttgctctttCatcccattcctcaggttttt	7	19	5	10	0	4	0	3	0	1	0	6	1	6	1	2	2	1	2	2	2	1	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr4:141320051C>T	uc011chi.1	-	9	1056	c.838G>A	c.(838-840)GAA>AAA	p.E280K	CLGN_uc003iii.2_Missense_Mutation_p.E280K	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	280	Lumenal (Potential).|1-1.				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)					TTTGCTCTTTCATCCCATTCC	0.358													29	190					0	0	0	0	T	141320051	T	T	141320051	3	4	284	1	0	0	0	0	1	0	0	0	3539	835	29	2	1026	2	CLGN	4	141320051	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	18579494	141320051	49834225	60	52692											
TRIM2	23321	broad.mit.edu	37	chr4	154197120	154197120	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccagacctccatcctgccCgagaaaggggtggccgcgct	7	5	13	16	4	0	2	0	0	0	2	2	3	2	2	6	3	1	1	6	3	1	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr4:154197120C>T	uc003ing.2	+	3	411	c.210C>T	c.(208-210)CCC>CCT	p.P70P	TRIM2_uc003inh.2_Silent_p.P97P|TRIM2_uc003ini.1_Silent_p.P88P	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	70						cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		CCATCCTGCCCGAGAAAGGGG	0.577													13	68					0	0	0	0	T	154197120	T	T	154197120	2	4	284	1	0	0	0	0	0	0	0	1	16561	639	23	1		1	TRIM2	4	154197120	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	12877069	154197120	36957156	61	52693											
HAND2	9464	broad.mit.edu	37	chr4	174449933	174449933	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacgtcggtcttcttgatctCtgccttgaaggcctccgcct	4	13	9	15	3	3	2	0	2	3	0	6	2	4	2	4	2	1	0	4	2	1	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr4:174449933C>T	uc003ith.1	-	1	1446	c.508G>A	c.(508-510)GAG>AAG	p.E170K	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Missense_Mutation_p.R135K|HAND2_uc010ire.1_Missense_Mutation_p.E170K	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	170					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TTCTTGATCTCTGCCTTGAAG	0.612													9	34					0	0	0	0	T	174449933	T	T	174449933	3	4	284	1	0	0	0	0	1	0	0	0	6989	922	32	2	153	2	HAND2	4	174449933	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	20252813	174449933	16704343	62	52694											
CDH6	1004	broad.mit.edu	37	chr5	31297509	31297509	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctatttttcagttgaatcaGaaacaggttagactttttga	12	16	7	6	0	2	4	2	2	0	2	2	4	2	4	1	1	1	2	1	1	4	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr5:31297509G>A	uc003jhe.1	+	4	963	c.637G>A	c.(637-639)GAA>AAA	p.E213K	CDH6_uc003jhd.1_Missense_Mutation_p.E213K	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	213	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						AGTTGAATCAGAAACAGGTTA	0.348													10	46					0	0	0	0	A	31297509	A	A	31297509	3	1	284	1	0	0	0	0	1	0	0	0	3129	943	33	2	647	2	CDH6	5	31297509	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		31297509	149617751	63	52695											
PTGER4	5734	broad.mit.edu	37	chr5	40681496	40681496	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagccactacgtggacaagcGattggcgggcctcacgctct	8	7	12	14	4	2	0	1	0	1	0	2	2	2	1	2	3	3	1	2	3	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr5:40681496G>C	uc003jlz.2	+	2	993	c.401G>C	c.(400-402)CGA>CCA	p.R134P		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	134	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						GTGGACAAGCGATTGGCGGGC	0.587											OREG0016588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	127					0	0	0	0	C	40681496	C	C	40681496	3	2	284	1	0	0	0	0	1	0	0	0	12808	1058	37	3	403	3	PTGER4	5	40681496	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	9383987	40681496	140233764	64	52696											
C5orf34	375444	broad.mit.edu	37	chr5	43503812	43503812	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccattttcactagttcaggaTaggaatattcatcagattgt	12	15	7	7	0	4	1	4	0	0	1	4	3	4	3	1	2	0	1	1	2	4	8			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr5:43503812T>G	uc003jnz.1	-	6	1300	c.983A>C	c.(982-984)TAT>TCT	p.Y328S		NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	328										breast(1)	1	Lung NSC(6;2.07e-05)					TAGTTCAGGATAGGAATATTC	0.353													26	112					0	0	0	0	G	43503812	G	G	43503812	3	3	284	1	0	0	0	0	1	0	0	0	2303	1406	49	5	969	5	C5orf34	5	43503812	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	2822316	43503812	137411448	65	52697											
PIK3R1	5295	broad.mit.edu	37	chr5	67589592	67589592	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agggaaaaaattacatgaatAtaacactcagtttcaagaaa	21	9	6	5	0	2	2	2	1	0	1	2	3	2	3	0	1	2	1	0	1	9	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr5:67589592A>G	uc003jva.2	+	11	1915	c.1355A>G	c.(1354-1356)TAT>TGT	p.Y452C	PIK3R1_uc003jvb.2_Missense_Mutation_p.Y452C|PIK3R1_uc003jvc.2_Missense_Mutation_p.Y152C|PIK3R1_uc003jvd.2_Missense_Mutation_p.Y182C|PIK3R1_uc003jve.2_Missense_Mutation_p.Y131C|PIK3R1_uc011crb.1_Missense_Mutation_p.Y122C	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	452					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.G446_Y452>VI(1)|p.E451_Y452del(1)|p.?(1)|p.Y452_Q455>SGGSRIK(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TTACATGAATATAACACTCAG	0.279			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			19	45					0	0	0	0	G	67589592	G	G	67589592	3	3	284	1	0	0	0	0	1	0	0	0	11973	449	16	5	1523	5	PIK3R1	5	67589592	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	24085780	67589592	113325668	66	52698											
MEF2C	4208	broad.mit.edu	37	chr5	88057031	88057031	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcctgctgatcattagatCaatatcttcgttaattttcc	9	18	5	9	1	3	2	2	1	1	1	5	2	4	2	2	0	2	2	2	0	4	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr5:88057031C>T	uc003kjj.2	-	4	1046	c.373G>A	c.(373-375)GAT>AAT	p.D125N	MEF2C_uc003kji.2_Missense_Mutation_p.D125N|MEF2C_uc003kjk.2_Missense_Mutation_p.D125N|MEF2C_uc003kjm.2_Intron|MEF2C_uc003kjl.2_Intron	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	125					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		ATCATTAGATCAATATCTTCG	0.453										HNSCC(66;0.2)			28	92					0	0	0	0	T	88057031	T	T	88057031	3	4	284	1	0	0	0	0	1	0	0	0	9510	826	29	2	1222	2	MEF2C	5	88057031	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	20467439	88057031	92858229	67	52699											
ANXA6	309	broad.mit.edu	37	chr5	150512081	150512081	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtccccagacagctcccctCggatgctggcttcaatcggc	7	8	10	16	2	1	1	1	0	0	1	5	2	3	2	4	3	2	3	4	3	1	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr5:150512081C>T	uc003ltl.1	-	10	844	c.692G>A	c.(691-693)CGA>CAA	p.R231Q	ANXA6_uc011dcp.1_Missense_Mutation_p.R199Q|ANXA6_uc003ltm.1_Missense_Mutation_p.R231Q|ANXA6_uc003ltn.1_Intron|ANXA6_uc003lto.1_Intron	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	231	Annexin 3.					melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding	p.R231Q(1)			0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGCTCCCCTCGGATGCTGGC	0.552													7	15					0	0	0	0	T	150512081	T	T	150512081	3	4	284	1	0	0	0	0	1	0	0	0	722	884	31	1	1397	1	ANXA6	5	150512081	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	62455050	150512081	30403179	68	52700											
FOXQ1	94234	broad.mit.edu	37	chr6	1313378	1313378	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgacgctggcggagatcaacGagtacctcatgggcaagttc	10	8	13	10	3	2	2	2	1	0	1	3	4	2	2	1	3	2	4	1	3	3	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr6:1313378G>A	uc003mtl.3	+	1	704	c.439G>A	c.(439-441)GAG>AAG	p.E147K		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	147	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		GGAGATCAACGAGTACCTCAT	0.637													8	38					0	0	0	0	A	1313378	A	A	1313378	3	1	284	1	0	0	0	0	1	0	0	0	6064	1059	37	1	441	1	FOXQ1	6	1313378	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		1313378	169801689	69	52701											
CCDC90A	63933	broad.mit.edu	37	chr6	13792146	13792146	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attatcaagcttgtgtgactCaagcatggttttgaggccag	10	13	11	7	0	2	2	2	2	0	0	2	2	2	2	1	2	2	3	1	2	3	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr6:13792146C>G	uc003nbd.2	-	8	1116	c.988G>C	c.(988-990)GAG>CAG	p.E330Q	uc003nbc.1_5'Flank|CCDC90A_uc010jpf.2_RNA	NM_001031713	NP_001026883	Q96AQ8	CC90A_HUMAN	coiled-coil domain containing 90A precursor	330						integral to membrane|mitochondrion					0	Breast(50;0.0027)|Ovarian(93;0.0964)	all_hematologic(90;0.117)				TTGTGTGACTCAAGCATGGTT	0.363													14	59					0	0	0	0	G	13792146	G	G	13792146	3	3	284	1	0	0	0	0	1	0	0	0	2881	835	29	2	99	2	CCDC90A	6	13792146	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	12478768	13792146	157322921	70	52702											
EHMT2	10919	broad.mit.edu	37	chr6	31855970	31855970	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccccacagtggggacagaaGaccatcccattcagctgaga	12	6	10	13	0	1	3	1	1	0	3	3	5	3	4	4	2	1	1	4	2	1	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr6:31855970G>C	uc003nxz.1	-	13	1603	c.1593C>G	c.(1591-1593)GTC>GTG	p.V531V	EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Silent_p.V322V|EHMT2_uc011don.1_Silent_p.V554V|EHMT2_uc003nya.1_Silent_p.V497V	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	531					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GGGGACAGAAGACCATCCCAT	0.642													25	36					0	0	0	0	C	31855970	C	C	31855970	2	2	284	1	0	0	0	0	0	0	0	1	5006	929	33	2		2	EHMT2	6	31855970	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	18063824	31855970	139259097	71	52703											
POLR1C	9533	broad.mit.edu	37	chr6	43497022	43497022	+	Frame_Shift_Del	DEL	T	-	-																															tggctgcggtggctcacaccTgtaatcccagcactttggga																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr6:43497022delT	uc003ovo.1	+	9	1015	c.958delT	c.(958-960)TGTfs	p.C320fs	XPO5_uc003ovp.2_Intron	NM_004875	NP_004866	O15160	RPAC1_HUMAN	RNA polymerase I subunit isoform 2	Error:Variant_position_missing_in_O15160_after_alignment					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			ggctcacacctgtaatcccag	0.129													---	---	---								-	43497022	-	-	43497022	7	5	284	1	0	1	0	1	0	0	0	0	12266	1580	55	0	1115	0	POLR1C	6	43497022	Frame_Shift_Del	DEL	T	TCGA-DQ-5625-01A-01D-1870-08	11641052	43497022	127618045	72	52704											
SIM1	6492	broad.mit.edu	37	chr6	100841664	100841664	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctgggagccaggcctatcGgcggggtccagaagctgcgg	6	6	18	11	3	0	1	0	0	0	1	2	2	1	2	3	6	4	2	3	6	2	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr6:100841664G>A	uc003pqj.3	-	10	1476	c.1269C>T	c.(1267-1269)GCC>GCT	p.A423A	SIM1_uc010kcu.2_Silent_p.A423A	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	423	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CAGGCCTATCGGCGGGGTCCA	0.597													26	36					0	0	0	0	A	100841664	A	A	100841664	2	1	284	1	0	0	0	0	0	0	0	1	14388	1103	39	1		1	SIM1	6	100841664	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	57344642	100841664	70273403	73	52705											
FYN	2534	broad.mit.edu	37	chr6	112017481	112017481	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aggagaggtgttgcccaaccTttgttcatatactcggtgac	9	12	11	9	1	1	2	1	1	0	1	2	3	1	2	2	3	3	2	2	3	3	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr6:112017481T>A	uc003pvj.2	-	9	1381	c.1041A>T	c.(1039-1041)AAA>AAT	p.K347N	FYN_uc003pvi.2_Missense_Mutation_p.K292N|FYN_uc003pvk.2_Missense_Mutation_p.K347N|FYN_uc003pvh.2_Missense_Mutation_p.K344N|FYN_uc010kdy.1_Intron	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	347	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTGCCCAACCTTTGTTCATAT	0.488													37	77					0	0	0	0	A	112017481	A	A	112017481	3	1	284	1	0	0	0	0	1	0	0	0	6160	1623	56	5	592	5	FYN	6	112017481	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	11175817	112017481	59097586	74	52706											
MED23	9439	broad.mit.edu	37	chr6	131917142	131917142	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagtctccagtgatttggaTaccggaagcaactctaaaaa	15	9	9	8	1	2	2	0	1	2	1	3	4	2	4	2	2	3	1	2	2	6	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr6:131917142T>C	uc003qcs.1	-	22	3114	c.2940A>G	c.(2938-2940)GTA>GTG	p.V980V	MED23_uc003qcq.2_Silent_p.V986V|MED23_uc003qcr.1_5'Flank|MED23_uc011eca.1_Silent_p.V621V	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	980					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		GTGATTTGGATACCGGAAGCA	0.378													3	123					0	0	0	0	C	131917142	C	C	131917142	2	2	284	1	0	0	0	0	0	0	0	1	9494	1393	49	5		5	MED23	6	131917142	Silent	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	19899661	131917142	39197925	75	52707											
MMD2	221938	broad.mit.edu	37	chr7	4947088	4947088	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtacctccagatggcatagTagtgggtaccagcaccaaat	12	8	11	10	0	0	1	0	0	0	1	1	1	1	1	4	3	3	5	4	3	5	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:4947088T>C	uc003sno.3	-	7	948	c.752A>G	c.(751-753)TAC>TGC	p.Y251C	MMD2_uc003snl.1_RNA|MMD2_uc003snn.3_Missense_Mutation_p.Y227C|MMD2_uc010ksq.2_3'UTR	NM_001100600	NP_001094070	Q8IY49	PAQRA_HUMAN	monocyte to macrophage	251	Helical; (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		GATGGCATAGTAGTGGGTACC	0.537													11	100					0	0	0	0	C	4947088	C	C	4947088	3	2	284	1	0	0	0	0	1	0	0	0	9697	1638	57	5	64	5	MMD2	7	4947088	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08		4947088	154191575	76	52708											
WIPF3	644150	broad.mit.edu	37	chr7	29918639	29918639	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaggttctaaaggaaccAacaaagaaggaggaggttct	17	7	11	6	0	2	1	0	0	2	1	2	4	2	4	1	5	2	2	1	5	8	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:29918639A>T	uc003taj.1	+	3	238	c.238A>T	c.(238-240)AAC>TAC	p.N80Y		NM_001080529	NP_001073998	A6NGB9	WIPF3_HUMAN	WAS/WASL interacting protein family, member 3	80										ovary(1)	1						TAAAGGAACCAACAAAGAAGG	0.517													4	15					0	0	0	0	T	29918639	T	T	29918639	3	4	284	1	0	0	0	0	1	0	0	0	17437	130	5	5	248	5	WIPF3	7	29918639	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	24971551	29918639	129220024	77	52709											
TARP	445347	broad.mit.edu	37	chr7	38299801	38299801	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaggtacatgtaatatgcaGaggtgtttgtgagctgcagc	10	11	15	5	0	0	2	0	1	0	1	0	3	0	3	0	3	5	6	0	3	3	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:38299801G>C	uc003tge.1	-	7	1213	c.836C>G	c.(835-837)TCT>TGT	p.S279C	uc003tfx.1_5'Flank|uc003tfz.1_Intron|TARP_uc003tgb.2_Missense_Mutation_p.S75C|TARP_uc003tgc.1_Missense_Mutation_p.S75C|TARP_uc003tgd.1_Missense_Mutation_p.S75C			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						GTAATATGCAGAGGTGTTTGT	0.423													9	58					0	0	0	0	C	38299801	C	C	38299801	3	2	284	1	0	0	0	0	1	0	0	0	15624	942	33	2	115	2	TARP	7	38299801	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	8381162	38299801	120838862	78	52710											
ZNF713	349075	broad.mit.edu	37	chr7	55980391	55980391	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggaggaagaaatgaatgAtggctcacagatggtgagat	15	7	16	3	0	1	5	1	3	0	3	1	9	1	8	0	5	0	1	0	5	3	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:55980391A>T	uc003trc.1	+	1	61	c.23A>T	c.(22-24)GAT>GTT	p.D8V	ZNF713_uc003tra.1_Missense_Mutation_p.D21V|MRPS17_uc003trb.2_Missense_Mutation_p.D8V	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GAAATGAATGATGGCTCACAG	0.408													15	18					0	0	0	0	T	55980391	T	T	55980391	3	4	284	1	0	0	0	0	1	0	0	0	18184	333	12	5	25	5	ZNF713	7	55980391	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	17680590	55980391	103158272	79	52711											
CLIP2	7461	broad.mit.edu	37	chr7	73771712	73771712	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acattgagcagctgctggctGaacgagacctggaacgggct	10	7	14	10	2	0	3	0	2	0	1	0	5	0	4	1	3	5	5	1	3	2	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:73771712G>A	uc003uam.2	+	6	1447	c.1120G>A	c.(1120-1122)GAA>AAA	p.E374K	CLIP2_uc003uan.2_Missense_Mutation_p.E374K	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	374	Potential.					microtubule associated complex				skin(3)	3						GCTGCTGGCTGAACGAGACCT	0.612													5	17					0	0	0	0	A	73771712	A	A	73771712	3	1	284	1	0	0	0	0	1	0	0	0	3548	1291	45	2	1138	2	CLIP2	7	73771712	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	17791321	73771712	85366951	80	52712											
KLHDC10	23008	broad.mit.edu	37	chr7	129756398	129756398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatcgggagggcctgataatGaagactatcctctcttcagg	11	10	11	9	1	2	3	1	2	1	1	5	4	3	4	2	3	0	0	2	3	4	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:129756398G>A	uc003vpj.1	+	3	502	c.367G>A	c.(367-369)GAA>AAA	p.E123K	KLHDC10_uc003vpk.1_Missense_Mutation_p.E94K|KLHDC10_uc010lmb.1_Intron	NM_014997	NP_055812	Q6PID8	KLD10_HUMAN	kelch domain containing 10	123	Kelch 1.										0						GCCTGATAATGAAGACTATCC	0.478													17	117					0	0	0	0	A	129756398	A	A	129756398	3	1	284	1	0	0	0	0	1	0	0	0	8394	1291	45	2	377	2	KLHDC10	7	129756398	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	55984686	129756398	29382265	81	52713											
MKLN1	4289	broad.mit.edu	37	chr7	131012684	131012684	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctggcggagctgtcgctgCggcgcccgagtgccggcttc	2	7	18	14	6	0	0	0	0	0	0	2	2	0	1	2	5	3	4	2	5	0	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:131012684C>G	uc011kpm.1	+	1	90	c.26C>G	c.(25-27)GCG>GGG	p.A9G	MKLN1_uc011kpl.1_Intron|MKLN1_uc010lmh.2_Missense_Mutation_p.A9G|MKLN1_uc003vqs.2_5'UTR|uc003vqr.1_5'Flank	NM_013255	NP_037387	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing	9					signal transduction	cytoplasm	protein binding			breast(1)	1	Melanoma(18;0.162)					GCTGTCGCTGCGGCGCCCGAG	0.682													7	27					0	0	0	0	G	131012684	G	G	131012684	3	3	284	1	0	0	0	0	1	0	0	0	9656	768	27	3	61	3	MKLN1	7	131012684	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	1256286	131012684	28125979	82	52714											
PODXL	5420	broad.mit.edu	37	chr7	131189187	131189191	+	Frame_Shift_Del	DEL	AGAAG	-	-																															accttcttctcctgcatctcAgaagaggtctccatcacttc																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:131189187_131189191delAGAAG	uc003vqw.3	-	9	1814_1818	c.1556_1560delCTTCT	c.(1555-1560)TCTTCTfs	p.S519fs	PODXL_uc003vqx.3_Frame_Shift_Del_p.S487fs	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	podocalyxin-like isoform 1 precursor	519_520	Cytoplasmic (Potential).				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)					CCTGCATCTCAGAAGAGGTCTCCAT	0.576													---	---	---								-	131189191	-	-	131189187	7	5	284	1	0	1	0	1	0	0	0	0	12235	175	7	0	120	0	PODXL	7	131189187	Frame_Shift_Del	DEL	AGAAG	TCGA-DQ-5625-01A-01D-1870-08	176503	131189187	27949476	83	52715											
ZC3HAV1	56829	broad.mit.edu	37	chr7	138764670	138764670	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcctggatttccatgcaaGaggtcctcttgactgccgtt	6	13	10	12	1	1	2	0	1	1	1	3	3	3	3	4	2	3	2	4	2	1	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:138764670G>C	uc003vun.2	-	4	1405	c.1017C>G	c.(1015-1017)CTC>CTG	p.L339L	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Silent_p.L339L	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	339					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						TTCCATGCAAGAGGTCCTCTT	0.552													24	113					0	0	0	0	C	138764670	C	C	138764670	2	2	284	1	0	0	0	0	0	0	0	1	17642	929	33	2		2	ZC3HAV1	7	138764670	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	7575483	138764670	20373993	84	52716											
JHDM1D	80853	broad.mit.edu	37	chr7	139833366	139833366	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agactcgagagcgtaattccTtaatgaaagttctagttcca	13	12	8	8	2	1	3	0	1	1	2	4	4	3	3	2	0	1	3	2	0	4	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:139833366T>A	uc003vvm.2	-	3	375	c.371A>T	c.(370-372)AAG>ATG	p.K124M		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	124					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					GCGTAATTCCTTAATGAAAGT	0.368													11	63					0	0	0	0	A	139833366	A	A	139833366	3	1	284	1	0	0	0	0	1	0	0	0	7987	1609	56	5	2526	5	JHDM1D	7	139833366	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	1068696	139833366	19305297	85	52717											
MGAM	8972	broad.mit.edu	37	chr7	141795497	141795497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggagggcgtcactgttgtgCggcctctgctccatgagtga	5	10	15	11	3	2	2	1	2	1	0	3	3	3	3	2	3	2	2	2	3	0	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:141795497C>T	uc003vwy.2	+	41	4957	c.4903C>T	c.(4903-4905)CGG>TGG	p.R1635W		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1635	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CACTGTTGTGCGGCCTCTGCT	0.468													71	159					0	0	0	0	T	141795497	T	T	141795497	3	4	284	1	0	0	0	0	1	0	0	0	9594	759	27	1	5061	1	MGAM	7	141795497	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	1962131	141795497	17343166	86	52718											
CNTNAP2	26047	broad.mit.edu	37	chr7	147674977	147674977	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaggatgctggtttcttatCatacaaagatcacctgccag	12	11	9	9	0	3	1	2	0	1	1	3	3	3	2	2	2	3	2	2	2	4	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr7:147674977C>T	uc003weu.1	+	15	2795	c.2279C>T	c.(2278-2280)TCA>TTA	p.S760L		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	760	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GGTTTCTTATCATACAAAGAT	0.473										HNSCC(39;0.1)			29	67					0	0	0	0	T	147674977	T	T	147674977	3	4	284	1	0	0	0	0	1	0	0	0	3662	838	29	2	2337	2	CNTNAP2	7	147674977	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	5879480	147674977	11463686	87	52719											
C8orf22	492307	broad.mit.edu	37	chr8	49986796	49986796	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaattttatttaatagggtTgcctgaagtggcagaatcca	12	14	10	5	0	0	3	0	2	0	1	1	3	1	3	2	2	1	2	2	2	6	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr8:49986796T>C	uc003xqq.3	+	4	320	c.137T>C	c.(136-138)TTG>TCG	p.L46S		NM_001007176	NP_001007177	Q8WWR9	PDPFL_HUMAN	hypothetical protein LOC492307	46											0		all_cancers(86;0.0452)|all_epithelial(80;0.000863)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				TTAATAGGGTTGCCTGAAGTG	0.333													6	96					0	0	0	0	C	49986796	C	C	49986796	3	2	284	1	0	0	0	0	1	0	0	0	2430	1821	63	5	147	5	C8orf22	8	49986796	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08		49986796	96377226	88	52720											
RGS20	8601	broad.mit.edu	37	chr8	54866744	54866744	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaattcctccgaacagaattCagtgaggaaaatatgctctt	14	11	8	8	1	2	2	1	1	1	1	4	5	4	3	2	1	2	1	2	1	6	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr8:54866744C>A	uc003xrp.2	+	5	944	c.852C>A	c.(850-852)TTC>TTA	p.F284L	RGS20_uc003xrq.2_Missense_Mutation_p.F169L|RGS20_uc010lye.2_Missense_Mutation_p.F76L|RGS20_uc010lyf.2_Missense_Mutation_p.F48L|RGS20_uc003xrs.2_Missense_Mutation_p.F137L|RGS20_uc003xrt.2_Missense_Mutation_p.F18L	NM_170587	NP_733466	O76081	RGS20_HUMAN	regulator of G-protein signaling 20 isoform a	284	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			GAACAGAATTCAGTGAGGAAA	0.413													17	99					1.99824e-07	2.0831e-07	1	0	A	54866744	A	A	54866744	3	1	284	1	0	0	0	0	1	0	0	0	13368	825	29	2	943	2	RGS20	8	54866744	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	4879948	54866744	91497278	89	52721											
PLAG1	5324	broad.mit.edu	37	chr8	57080731	57080731	+	Frame_Shift_Del	DEL	T	-	-																															cacacagttggcaaggaaagTtttttcttggtttggtttca																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr8:57080731delT	uc003xsq.3	-	2	549	c.98delA	c.(97-99)AACfs	p.N33fs	PLAG1_uc003xsr.3_Frame_Shift_Del_p.N33fs|PLAG1_uc010lyi.2_Frame_Shift_Del_p.N33fs|PLAG1_uc010lyj.2_Intron	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	33	Interacts with KPNA2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GCAAGGAAAGTTTTTTCTTGG	0.453			T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								---	---	---								-	57080731	-	-	57080731	7	5	284	1	0	1	0	1	0	0	0	0	12073	1725	60	0	1412	0	PLAG1	8	57080731	Frame_Shift_Del	DEL	T	TCGA-DQ-5625-01A-01D-1870-08	2213987	57080731	89283291	90	52722											
PMP2	5375	broad.mit.edu	37	chr8	82357103	82357103	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaattcctggcctagcttGaaggagatttctgtattttt	9	17	8	7	0	2	2	1	1	1	1	3	3	3	2	2	2	1	2	2	2	4	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr8:82357103G>C	uc003ycb.1	-	2	293	c.195C>G	c.(193-195)TTC>TTG	p.F65L	PMP2_uc010lzv.1_Intron	NM_002677	NP_002668	P02689	MYP2_HUMAN	peripheral myelin protein 2	65						cytoplasm	cholesterol binding|fatty acid binding|transporter activity				0			Epithelial(68;0.186)			GGCCTAGCTTGAAGGAGATTT	0.393													17	101					0	0	0	0	C	82357103	C	C	82357103	3	2	284	1	0	0	0	0	1	0	0	0	12193	1281	45	2	215	2	PMP2	8	82357103	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	25276372	82357103	64006919	91	52723											
NBN	4683	broad.mit.edu	37	chr8	90955524	90955524	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttctagttctgtattctttCgagcatgatgagctattaga	9	17	8	7	1	3	3	0	2	3	1	4	4	3	3	0	0	2	4	0	0	4	8			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr8:90955524C>T	uc003yej.1	-	14	2251	c.2141G>A	c.(2140-2142)CGA>CAA	p.R714Q	NBN_uc003yei.1_Missense_Mutation_p.R632Q|NBN_uc011lgb.1_Missense_Mutation_p.R714Q	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	714					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TGTATTCTTTCGAGCATGATG	0.398								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				22	167					0	0	0	0	T	90955524	T	T	90955524	3	4	284	1	0	0	0	0	1	0	0	0	10244	884	31	1	135	1	NBN	8	90955524	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	8598421	90955524	55408498	92	52724											
KCNS2	3788	broad.mit.edu	37	chr8	99441238	99441238	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgtggggatttccatcttctCcgtggtggcctacaccattg	5	13	11	12	2	2	0	0	0	2	0	4	1	3	1	4	4	1	0	4	4	1	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr8:99441238C>T	uc003yin.2	+	2	1381	c.1031C>T	c.(1030-1032)TCC>TTC	p.S344F		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	344	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			TCCATCTTCTCCGTGGTGGCC	0.582													16	91					0	0	0	0	T	99441238	T	T	99441238	3	4	284	1	0	0	0	0	1	0	0	0	8128	855	30	2	1033	2	KCNS2	8	99441238	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	8485714	99441238	46922784	93	52725											
COL14A1	7373	broad.mit.edu	37	chr8	121222028	121222028	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcttctgaccttctactgtAcgacgtgactgagaacagca	10	10	10	11	2	2	3	0	3	2	1	2	5	2	3	1	1	4	3	1	1	3	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr8:121222028A>G	uc003yox.2	+	12	1620	c.1355A>G	c.(1354-1356)TAC>TGC	p.Y452C	COL14A1_uc003yoy.2_Missense_Mutation_p.Y130C|COL14A1_uc010mde.1_Missense_Mutation_p.Y130C	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	452	Fibronectin type-III 3.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CTTCTACTGTACGACGTGACT	0.453													4	124					0	0	0	0	G	121222028	G	G	121222028	3	3	284	1	0	0	0	0	1	0	0	0	3686	391	14	5	1397	5	COL14A1	8	121222028	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	21780790	121222028	25141994	94	52726											
FAM91A1	157769	broad.mit.edu	37	chr8	124810426	124810426	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaattacacgctgcttgtttCcatggctcccctcaccaatg	9	12	6	14	1	1	0	1	0	0	0	3	0	3	0	4	1	2	4	4	1	3	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr8:124810426C>G	uc003yqv.2	+	16	1569	c.1508C>G	c.(1507-1509)TCC>TGC	p.S503C	FAM91A1_uc011lik.1_Missense_Mutation_p.S503C|FAM91A1_uc011lil.1_Missense_Mutation_p.S261C	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	503										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			CTGCTTGTTTCCATGGCTCCC	0.493													15	179					0	0	0	0	G	124810426	G	G	124810426	3	3	284	1	0	0	0	0	1	0	0	0	5683	855	30	2	1570	2	FAM91A1	8	124810426	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	3588398	124810426	21553596	95	52727											
PLEC	5339	broad.mit.edu	37	chr8	144992659	144992659	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaagagcgagatggtctgcTcggtgtaggggtcacggtag	8	8	19	6	3	2	2	1	0	1	2	3	4	2	3	0	6	2	3	0	6	3	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr8:144992659T>A	uc003zaf.1	-	32	11911	c.11741A>T	c.(11740-11742)GAG>GTG	p.E3914V	PLEC_uc003zab.1_Missense_Mutation_p.E3777V|PLEC_uc003zac.1_Missense_Mutation_p.E3781V|PLEC_uc003zad.2_Missense_Mutation_p.E3777V|PLEC_uc003zae.1_Missense_Mutation_p.E3745V|PLEC_uc003zag.1_Missense_Mutation_p.E3755V|PLEC_uc003zah.2_Missense_Mutation_p.E3763V|PLEC_uc003zaj.2_Missense_Mutation_p.E3804V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3914	Globular 2.|Plectin 19.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GATGGTCTGCTCGGTGTAGGG	0.682													4	16					0	0	0	0	A	144992659	A	A	144992659	3	1	284	1	0	0	0	0	1	0	0	0	12107	1551	54	5	2317	5	PLEC	8	144992659	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	20182233	144992659	1371363	96	52728											
MPDZ	8777	broad.mit.edu	37	chr9	13223589	13223589	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctatgggccacactgccctCttgtatctcttgaacaaata	10	12	6	13	0	2	1	0	1	2	0	3	1	2	1	3	1	2	1	3	1	5	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr9:13223589C>T	uc010mia.1	-	4	571	c.514G>A	c.(514-516)GAG>AAG	p.E172K	MPDZ_uc010mhy.2_Missense_Mutation_p.E172K|MPDZ_uc010mhz.2_Missense_Mutation_p.E172K|MPDZ_uc011lmn.1_Missense_Mutation_p.E172K|MPDZ_uc003zlb.3_Missense_Mutation_p.E172K	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	172	PDZ 1.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		ACACTGCCCTCTTGTATCTCT	0.448													8	48					0	0	0	0	T	13223589	T	T	13223589	3	4	284	1	0	0	0	0	1	0	0	0	9775	922	32	2	5779	2	MPDZ	9	13223589	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08		13223589	127989842	97	52729											
IFNA8	3445	broad.mit.edu	37	chr9	21409439	21409439	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagatgatccagcagaccttCaacctcttcagcacaaagga	14	7	8	12	0	3	3	2	1	1	2	4	5	4	4	3	1	3	2	3	1	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr9:21409439C>G	uc003zpc.1	+	1	294	c.264C>G	c.(262-264)TTC>TTG	p.F88L		NM_002170	NP_002161	P32881	IFNA8_HUMAN	interferon, alpha 8 precursor	88					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		AGCAGACCTTCAACCTCTTCA	0.473													29	143					0	0	0	0	G	21409439	G	G	21409439	3	3	284	1	0	0	0	0	1	0	0	0	7582	825	29	2	266	2	IFNA8	9	21409439	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	8185850	21409439	119803992	98	52730											
RG9MTD3	158234	broad.mit.edu	37	chr9	37776359	37776359	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatacatggtcagaaaccaGaatgggaaaaactatcattc	18	8	8	7	0	2	2	2	0	0	2	3	4	2	3	1	2	3	0	1	2	7	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr9:37776359G>C	uc004aai.2	+	8	878	c.801G>C	c.(799-801)CAG>CAC	p.Q267H	RG9MTD3_uc011lqo.1_Missense_Mutation_p.Q216H|RG9MTD3_uc011lqp.1_Missense_Mutation_p.Q189H|RG9MTD3_uc011lqq.1_Missense_Mutation_p.Q156H|RG9MTD3_uc004aaj.2_RNA|RG9MTD3_uc004aak.2_Missense_Mutation_p.Q172H	NM_144964	NP_659401	Q6PF06	RG9D3_HUMAN	RNA (guanine-9-) methyltransferase domain	267							methyltransferase activity				0				GBM - Glioblastoma multiforme(29;0.00817)|Lung(182;0.226)		TCAGAAACCAGAATGGGAAAA	0.448													12	18					0	0	0	0	C	37776359	C	C	37776359	3	2	284	1	0	0	0	0	1	0	0	0	13338	933	33	2	827	2	RG9MTD3	9	37776359	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	16366920	37776359	103437072	99	52731											
IARS	3376	broad.mit.edu	37	chr9	95014160	95014160	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgacacaatcctccatcccaTtttcaccctaatgagtaaaa	14	11	3	13	0	1	2	1	2	0	0	4	2	4	2	4	0	0	1	4	0	4	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr9:95014160T>C	uc004art.1	-	22	2494	c.2237A>G	c.(2236-2238)AAT>AGT	p.N746S	IARS_uc004ars.1_Missense_Mutation_p.N591S|IARS_uc004aru.3_Missense_Mutation_p.N746S|IARS_uc010mqr.2_Missense_Mutation_p.N636S|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	746					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	CTCCATCCCATTTTCACCCTA	0.328													9	46					0	0	0	0	C	95014160	C	C	95014160	3	2	284	1	0	0	0	0	1	0	0	0	7512	1493	52	5	1603	5	IARS	9	95014160	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	57237801	95014160	46199271	100	52732											
SUSD1	64420	broad.mit.edu	37	chr9	114820851	114820851	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacatctttggccagtagttCtgcagccacgtatccatcag	10	11	8	12	1	3	0	1	0	2	0	4	0	4	0	3	1	3	4	3	1	3	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr9:114820851C>T	uc004bfu.2	-	14	2007	c.1966G>A	c.(1966-1968)GAA>AAA	p.E656K	SUSD1_uc010mui.2_Missense_Mutation_p.E656K|SUSD1_uc010muj.2_Missense_Mutation_p.E656K	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	656	Extracellular (Potential).					integral to membrane	calcium ion binding				0						GCCAGTAGTTCTGCAGCCACG	0.483													30	110					0	0	0	0	T	114820851	T	T	114820851	3	4	284	1	0	0	0	0	1	0	0	0	15473	922	32	2	293	2	SUSD1	9	114820851	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	19806691	114820851	26392580	101	52733											
ZNF618	114991	broad.mit.edu	37	chr9	116811467	116811476	+	Frame_Shift_Del	DEL	GCCGGCATGT	-	-																															gcacgtccgccttctccaagGccggcatgtgccttcgctgc																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr9:116811467_116811476delGCCGGCATGT	uc004bid.2	+	15	1984_1993	c.1885_1894delGCCGGCATGT	c.(1885-1896)GCCGGCATGTGCfs	p.A629fs	ZNF618_uc004bic.2_Frame_Shift_Del_p.A536fs|ZNF618_uc011lxi.1_Frame_Shift_Del_p.A596fs|ZNF618_uc011lxj.1_Frame_Shift_Del_p.A597fs|ZNF618_uc010mvb.2_Frame_Shift_Del_p.A219fs	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	629_632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTCTCCAAGGCCGGCATGTGCCTTCGCTG	0.624													---	---	---								-	116811476	-	-	116811467	7	5	284	1	0	1	0	1	0	0	0	0	18109	1203	42	0	1660	0	ZNF618	9	116811467	Frame_Shift_Del	DEL	GCCGGCATGT	TCGA-DQ-5625-01A-01D-1870-08	1990616	116811467	24401964	102	52734											
SPTAN1	6709	broad.mit.edu	37	chr9	131394439	131394439	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatccgagccatgagaagtCagctcaaaaagatcgaggac	17	5	10	9	2	2	2	2	1	0	2	4	6	3	3	2	1	2	1	2	1	4	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr9:131394439C>G	uc004bvl.3	+	52	6894	c.6781C>G	c.(6781-6783)CAG>GAG	p.Q2261E	SPTAN1_uc004bvm.3_Missense_Mutation_p.Q2266E|SPTAN1_uc004bvn.3_Missense_Mutation_p.Q2241E|SPTAN1_uc004bvo.3_Missense_Mutation_p.Q28E|SPTAN1_uc004bvp.3_Missense_Mutation_p.Q4E	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2261	Spectrin 23.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CATGAGAAGTCAGCTCAAAAA	0.637													6	24					0	0	0	0	G	131394439	G	G	131394439	3	3	284	1	0	0	0	0	1	0	0	0	15183	827	29	2	7002	2	SPTAN1	9	131394439	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	14582972	131394439	9818992	103	52735											
SPTAN1	6709	broad.mit.edu	37	chr9	131395123	131395123	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgcaagaatacatggctttCatgatcagccgcgaaactga	13	10	9	9	2	2	3	2	2	0	1	2	4	2	3	1	1	4	2	1	1	4	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr9:131395123C>G	uc004bvl.3	+	55	7295	c.7182C>G	c.(7180-7182)TTC>TTG	p.F2394L	SPTAN1_uc004bvm.3_Missense_Mutation_p.F2399L|SPTAN1_uc004bvn.3_Missense_Mutation_p.F2374L|SPTAN1_uc004bvo.3_Missense_Mutation_p.F161L|SPTAN1_uc004bvp.3_Missense_Mutation_p.F137L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2394	EF-hand 2.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ACATGGCTTTCATGATCAGCC	0.597													26	97					0	0	0	0	G	131395123	G	G	131395123	3	3	284	1	0	0	0	0	1	0	0	0	15183	825	29	2	7415	2	SPTAN1	9	131395123	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	684	131395123	9818308	104	52736											
FIBCD1	84929	broad.mit.edu	37	chr9	133799178	133799178	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcacagtacacctggaagcCggccgggtagtgggtgggaa	9	6	17	9	2	1	0	1	0	0	0	1	2	1	2	3	5	2	2	3	5	4	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr9:133799178C>T	uc004bzz.2	-	4	1047	c.802G>A	c.(802-804)GGC>AGC	p.G268S	FIBCD1_uc011mcc.1_Missense_Mutation_p.G268S	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	268	Fibrinogen C-terminal.|Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		ACCTGGAAGCCGGCCGGGTAG	0.697													32	32					0	0	0	0	T	133799178	T	T	133799178	3	4	284	1	0	0	0	0	1	0	0	0	5916	652	23	1	599	1	FIBCD1	9	133799178	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	2404055	133799178	7414253	105	52737											
NOTCH1	4851	broad.mit.edu	37	chr9	139413087	139413087	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtagaaggaggccacacggTcatggcaggtggcgccgtgg	9	5	18	9	3	1	1	1	0	0	1	1	2	1	2	2	7	0	2	2	7	2	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr9:139413087T>A	uc004chz.2	-	6	1055	c.1055A>T	c.(1054-1056)GAC>GTC	p.D352V		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	352	Extracellular (Potential).|EGF-like 9; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGCCACACGGTCATGGCAGGT	0.647			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			8	8					0	0	0	0	A	139413087	A	A	139413087	3	1	284	1	0	0	0	0	1	0	0	0	10601	1667	58	5	6728	5	NOTCH1	9	139413087	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	5613909	139413087	1800344	106	52738											
CUBN	8029	broad.mit.edu	37	chr10	17113504	17113504	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggagaatgacttggctttggGgctggtggatggtccaccta	7	11	16	7	0	0	2	0	1	0	1	1	4	1	3	2	7	0	2	2	7	2	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr10:17113504G>A	uc001ioo.2	-	19	2598	c.2546C>T	c.(2545-2547)CCC>CTC	p.P849L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	849	CUB 4.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGGCTTTGGGGCTGGTGGAT	0.458													3	63					0	0	0	0	A	17113504	A	A	17113504	3	1	284	1	0	0	0	0	1	0	0	0	4068	1232	43	4	8521	4	CUBN	10	17113504	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		17113504	118421243	107	52739											
RHOBTB1	9886	broad.mit.edu	37	chr10	62648790	62648790	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gatttccagaattgcaggtgCctgcgggaaatcagcgctgc	9	9	13	10	2	1	1	1	0	0	1	2	3	2	2	2	2	5	2	2	2	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr10:62648790C>T	uc001jli.2	-	7	1074	c.636G>A	c.(634-636)AGG>AGA	p.R212R	RHOBTB1_uc001jlh.2_Silent_p.R212R|RHOBTB1_uc001jlj.2_Silent_p.R212R|RHOBTB1_uc001jlk.2_Silent_p.R212R|RHOBTB1_uc009xpe.1_Silent_p.R150R|RHOBTB1_uc001jll.2_5'UTR	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	212					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					ATTGCAGGTGCCTGCGGGAAA	0.473													47	174					0	0	0	0	T	62648790	T	T	62648790	2	4	284	1	0	0	0	0	0	0	0	1	13398	738	26	4		4	RHOBTB1	10	62648790	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	45535286	62648790	72885957	108	52740											
WAPAL	23063	broad.mit.edu	37	chr10	88203112	88203112	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctccatgtgtttgccggcatGctgaagggctgagagaattg	8	11	14	8	1	0	3	0	2	0	1	1	4	1	3	2	2	2	4	2	2	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr10:88203112G>A	uc001kdo.2	-	17	3773	c.3331C>T	c.(3331-3333)CAT>TAT	p.H1111Y	WAPAL_uc009xsv.2_Missense_Mutation_p.H370Y|WAPAL_uc001kdn.2_Missense_Mutation_p.H1148Y|WAPAL_uc009xsw.2_Missense_Mutation_p.H1105Y	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	1111	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						TTGCCGGCATGCTGAAGGGCT	0.398													10	45					0	0	0	0	A	88203112	A	A	88203112	3	1	284	1	0	0	0	0	1	0	0	0	17316	1319	46	4	253	4	WAPAL	10	88203112	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	25554322	88203112	47331635	109	52741											
PAPSS2	9060	broad.mit.edu	37	chr10	89472945	89472946	+	Frame_Shift_Del	DEL	AG	-	-																															atgtccgtcatggccttaacAgaaatctcggattctctcct																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr10:89472945_89472946delAG	uc001kex.2	+	3	522_523	c.259_260delAG	c.(259-261)AGAfs	p.R87fs	PAPSS2_uc001kew.2_Frame_Shift_Del_p.R87fs|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	87	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		TGGCCTTAACAGAAATCTCGGA	0.51													---	---	---								-	89472946	-	-	89472945	7	5	284	1	0	1	0	1	0	0	0	0	11489	180	7	0	269	0	PAPSS2	10	89472945	Frame_Shift_Del	DEL	AG	TCGA-DQ-5625-01A-01D-1870-08	1269833	89472945	46061802	110	52742											
KCNIP2	30819	broad.mit.edu	37	chr10	103588905	103588905	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctcctgcagctgctccagaCcctcaggccggtgacacacg	7	6	11	17	2	1	2	1	1	0	1	3	2	3	2	4	2	3	4	4	2	0	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr10:103588905C>A	uc001kub.2	-	4	627	c.275G>T	c.(274-276)GGT>GTT	p.G92V	KCNIP2_uc010qqg.1_5'Flank|KCNIP2_uc001ktx.2_RNA|KCNIP2_uc001kty.2_Missense_Mutation_p.V14F|KCNIP2_uc001ktz.2_Missense_Mutation_p.G47V|KCNIP2_uc009xwu.2_Missense_Mutation_p.G42V|KCNIP2_uc009xwv.2_Missense_Mutation_p.G42V|KCNIP2_uc001kuc.2_Missense_Mutation_p.G107V|KCNIP2_uc001kue.2_Missense_Mutation_p.G74V|KCNIP2_uc001kud.2_Missense_Mutation_p.G42V|KCNIP2_uc001kuf.2_Missense_Mutation_p.G42V|KCNIP2_uc001kua.2_Missense_Mutation_p.V14F|KCNIP2_uc009xww.2_RNA|KCNIP2_uc010qqh.1_Missense_Mutation_p.G47V|KCNIP2_uc010qqi.1_Missense_Mutation_p.G42V	NM_173191	NP_775283	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2 isoform 2	92	EF-hand 1; degenerate.				clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		CTGCTCCAGACCCTCAGGCCG	0.617													7	18					5.18039e-06	5.35903e-06	1	0	A	103588905	A	A	103588905	3	1	284	1	0	0	0	0	1	0	0	0	8079	507	18	4	633	4	KCNIP2	10	103588905	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	14115960	103588905	31945842	111	52743											
PPRC1	23082	broad.mit.edu	37	chr10	103901291	103901291	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctccagcctccattgggaGagctgttccccaacctaaaa	10	8	8	15	0	0	1	0	0	0	1	3	2	3	1	7	1	3	2	7	1	3	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr10:103901291G>A	uc001kum.2	+	5	3065	c.3026G>A	c.(3025-3027)AGA>AAA	p.R1009K	PPRC1_uc001kun.2_Missense_Mutation_p.R889K|PPRC1_uc010qqj.1_Missense_Mutation_p.R1009K|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1009	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TCCATTGGGAGAGCTGTTCCC	0.572													9	40					0	0	0	0	A	103901291	A	A	103901291	3	1	284	1	0	0	0	0	1	0	0	0	12470	942	33	2	3044	2	PPRC1	10	103901291	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	312386	103901291	31633456	112	52744											
SHOC2	8036	broad.mit.edu	37	chr10	112760233	112760233	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagactgtcagcaatacccaGatcattagcaaaatgcagtg	15	8	8	10	0	2	2	2	0	0	2	2	2	2	2	1	0	4	3	1	0	5	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr10:112760233G>C	uc001kzl.3	+	4	1251	c.902G>C	c.(901-903)AGA>ACA	p.R301T	SHOC2_uc009xxx.2_Missense_Mutation_p.R301T|SHOC2_uc010qrg.1_5'UTR|SHOC2_uc001kzn.2_Missense_Mutation_p.R255T	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	301	LRR 9.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		GCAATACCCAGATCATTAGCA	0.323													11	38					0	0	0	0	C	112760233	C	C	112760233	3	2	284	1	0	0	0	0	1	0	0	0	14352	942	33	2	912	2	SHOC2	10	112760233	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	8858942	112760233	22774514	113	52745											
PRMT3	10196	broad.mit.edu	37	chr11	20483563	20483563	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actatcagccttgtagcagtGagtgatgtgaataaacatgc	13	11	10	7	0	1	3	1	3	0	0	1	3	1	3	1	0	4	2	1	0	5	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:20483563G>T	uc001mqb.2	+	12	1327	c.1110G>T	c.(1108-1110)GTG>GTT	p.V370V	PRMT3_uc001mqc.2_Silent_p.V293V|PRMT3_uc010rdn.1_Silent_p.V308V	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1	370							zinc ion binding				0						TTGTAGCAGTGAGTGATGTGA	0.373													23	93					9.57634e-11	1.01796e-10	1	0	T	20483563	T	T	20483563	2	4	284	1	0	0	0	0	0	0	0	1	12600	1277	45	2		2	PRMT3	11	20483563	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		20483563	114522953	114	52746											
CCDC34	91057	broad.mit.edu	37	chr11	27362349	27362349	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttctgctatttcctttttCtcctgtatttcagcttgctg	3	23	5	10	0	3	0	1	0	2	0	5	0	4	0	2	0	3	4	2	0	2	9			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:27362349C>G	uc001mrh.1	-	5	855	c.801G>C	c.(799-801)GAG>GAC	p.E267D		NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	267	Potential.										0						TTTCCTTTTTCTCCTGTATTT	0.343													16	46					0	0	0	0	G	27362349	G	G	27362349	3	3	284	1	0	0	0	0	1	0	0	0	2820	912	32	2	328	2	CCDC34	11	27362349	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	6878786	27362349	107644167	115	52747											
DCDC1	341019	broad.mit.edu	37	chr11	31329370	31329370	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctgatactgctgctgaatGcacgagtctgttggggccaa	8	12	12	9	1	2	2	0	2	2	0	2	3	2	2	1	2	4	4	1	2	3	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:31329370G>C	uc001msv.2	-	4	452	c.250C>G	c.(250-252)CAT>GAT	p.H84D	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	84					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					GCTGCTGAATGCACGAGTCTG	0.423													39	149					0	0	0	0	C	31329370	C	C	31329370	3	2	284	1	0	0	0	0	1	0	0	0	4301	1319	46	4	838	4	DCDC1	11	31329370	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	3967021	31329370	103677146	116	52748											
QSER1	79832	broad.mit.edu	37	chr11	32956153	32956153	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgctaccaatcttgaatctGaagaagacagtgaagctcct	13	10	8	10	0	2	5	0	3	2	2	3	5	3	5	2	0	3	2	2	0	6	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:32956153G>C	uc001mty.2	+	4	3229	c.2962G>C	c.(2962-2964)GAA>CAA	p.E988Q	QSER1_uc001mtz.1_Missense_Mutation_p.E749Q|QSER1_uc001mua.2_Missense_Mutation_p.E493Q	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	988										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					TCTTGAATCTGAAGAAGACAG	0.393													14	46					0	0	0	0	C	32956153	C	C	32956153	3	2	284	1	0	0	0	0	1	0	0	0	12947	1291	45	2	2968	2	QSER1	11	32956153	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	1626783	32956153	102050363	117	52749			1	79		3	3	688	G		1.197039e-05
QSER1	79832	broad.mit.edu	37	chr11	32956461	32956461	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaggaagacaacagtaatcaGaaacagctgaaaagacctgc	19	4	10	8	0	1	4	1	1	0	3	1	6	1	5	1	1	4	2	1	1	6	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:32956461G>C	uc001mty.2	+	4	3537	c.3270G>C	c.(3268-3270)CAG>CAC	p.Q1090H	QSER1_uc001mtz.1_Missense_Mutation_p.Q851H|QSER1_uc001mua.2_Missense_Mutation_p.Q595H	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1090										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					ACAGTAATCAGAAACAGCTGA	0.398													21	82					0	0	0	0	C	32956461	C	C	32956461	3	2	284	1	0	0	0	0	1	0	0	0	12947	933	33	2	3276	2	QSER1	11	32956461	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	308	32956461	102050055	118	52750			1	79		3	3	688	G		1.197039e-05
QSER1	79832	broad.mit.edu	37	chr11	32956840	32956840	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagtccatcagataaagttGataatgaacttaaaaacttg	18	11	6	6	0	1	3	1	2	0	1	2	3	2	3	1	0	2	1	1	0	7	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:32956840G>C	uc001mty.2	+	4	3916	c.3649G>C	c.(3649-3651)GAT>CAT	p.D1217H	QSER1_uc001mtz.1_Missense_Mutation_p.D978H|QSER1_uc001mua.2_Missense_Mutation_p.D722H	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1217										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					AGATAAAGTTGATAATGAACT	0.398													35	136					0	0	0	0	C	32956840	C	C	32956840	3	2	284	1	0	0	0	0	1	0	0	0	12947	1290	45	2	3655	2	QSER1	11	32956840	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	379	32956840	102049676	119	52751			1	79		3	3	688	G		1.197039e-05
ACP2	53	broad.mit.edu	37	chr11	47261735	47261735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctgcatccggaagaggaCggtgaggagcagcactatga	11	5	16	9	2	0	3	0	2	0	1	1	6	1	6	2	5	3	3	2	5	2	1	rs4647764		TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:47261735C>T	uc001nei.2	-	11	1321	c.1204G>A	c.(1204-1206)GTC>ATC	p.V402I	ACP2_uc010rhe.1_Missense_Mutation_p.V374I|ACP2_uc009ylj.2_Missense_Mutation_p.V330I|ACP2_uc010rhf.1_Missense_Mutation_p.V370I|ACP2_uc010rhg.1_Missense_Mutation_p.V339I|ACP2_uc010rhh.1_Missense_Mutation_p.V215I	NM_001610	NP_001601	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal isoform 1	402	Cytoplasmic (Potential).					integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			ovary(1)	1						CGGAAGAGGACGGTGAGGAGC	0.612													9	40					0	0	0	0	T	47261735	T	T	47261735	3	4	284	1	0	0	0	0	1	0	0	0	163	536	19	1	71	1	ACP2	11	47261735	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	14304895	47261735	87744781	120	52752											
NDUFS3	4722	broad.mit.edu	37	chr11	47600853	47600853	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctccgttctgttgctgccgGtgaggcgggagagcgccggg	3	8	18	12	5	1	2	0	1	1	1	2	3	2	2	4	4	3	3	4	4	0	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:47600853G>A	uc001nga.2	+	2	182	c.100G>A	c.(100-102)GTG>ATG	p.V34M	NDUFS3_uc001nft.3_Intron|KBTBD4_uc001nfw.1_5'Flank|KBTBD4_uc001nfx.2_5'Flank|KBTBD4_uc001nfz.2_5'Flank|KBTBD4_uc001nfy.2_5'Flank|NDUFS3_uc010rhn.1_Missense_Mutation_p.V34M	NM_004551	NP_004542	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3	34					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	GTTGCTGCCGGTGAGGCGGGA	0.667													4	55					0	0	0	0	A	47600853	A	A	47600853	3	1	284	1	0	0	0	0	1	0	0	0	10347	1261	44	4	106	4	NDUFS3	11	47600853	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	339118	47600853	87405663	121	52753											
OR5D13	390142	broad.mit.edu	37	chr11	55540942	55540942	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atctgaaagaaatcaaagcaGcacacccacttttattctct	15	11	4	11	0	3	2	1	1	2	1	4	2	3	2	1	0	2	2	1	0	4	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:55540942G>C	uc010ril.1	+	1	29	c.29G>C	c.(28-30)AGC>ACC	p.S10T		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				AATCAAAGCAGCACACCCACT	0.383													24	85					0	0	0	0	C	55540942	C	C	55540942	3	2	284	1	0	0	0	0	1	0	0	0	11208	971	34	4	31	4	OR5D13	11	55540942	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	7940089	55540942	79465574	122	52754											
MS4A3	932	broad.mit.edu	37	chr11	59828723	59828723	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcgggaccagaagagctgaaTacttctgtctaccagcccat	11	8	10	12	1	2	3	0	1	2	2	2	4	2	4	3	1	4	1	3	1	4	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:59828723T>C	uc001nom.2	+	2	218	c.90T>C	c.(88-90)AAT>AAC	p.N30N	MS4A3_uc001non.2_Silent_p.N30N|MS4A3_uc001noo.2_Intron	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	30	Cytoplasmic (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				AAGAGCTGAATACTTCTGTCT	0.478													35	58					0	0	0	0	C	59828723	C	C	59828723	2	2	284	1	0	0	0	0	0	0	0	1	9914	1403	49	5		5	MS4A3	11	59828723	Silent	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	4287781	59828723	75177793	123	52755											
SLC29A2	3177	broad.mit.edu	37	chr11	66136984	66136984	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgtgctgttgccggccccgGccagtcgcgcctggaagtac	4	8	14	15	4	0	0	0	0	0	0	1	1	0	1	5	3	3	3	5	3	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:66136984G>A	uc001oht.2	-	3	360	c.131C>T	c.(130-132)GCC>GTC	p.A44V	SLC29A2_uc001ohs.2_5'UTR|SLC29A2_uc010rpb.1_RNA|SLC29A2_uc009yrf.2_5'UTR|SLC29A2_uc001ohu.2_Missense_Mutation_p.A44V|SLC29A2_uc001ohv.2_Missense_Mutation_p.A44V|uc001ohw.1_RNA	NM_001532	NP_001523	Q14542	S29A2_HUMAN	solute carrier family 29 (nucleoside	44					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1						GCCGGCCCCGGCCAGTCGCGC	0.547													5	284					0	0	0	0	A	66136984	A	A	66136984	3	1	284	1	0	0	0	0	1	0	0	0	14599	1203	42	4	1279	4	SLC29A2	11	66136984	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	6308261	66136984	68869532	124	52756											
RBM4	5936	broad.mit.edu	37	chr11	66407477	66407477	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggagcttcgagccaagtttGaggagtatggtccggtcatc	9	10	14	8	2	1	1	1	1	0	0	4	4	2	3	2	4	2	3	2	4	2	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:66407477G>C	uc009yrj.2	+	2	783	c.295G>C	c.(295-297)GAG>CAG	p.E99Q	RBM4_uc009yrk.2_Intron|RBM4_uc001oiv.2_Missense_Mutation_p.E99Q|RBM4_uc001oiw.1_Missense_Mutation_p.E99Q|RBM4_uc001oix.1_Missense_Mutation_p.E99Q|RBM4_uc010rpj.1_Missense_Mutation_p.E99Q|RBM4_uc001oiy.1_Missense_Mutation_p.E99Q|RBM4_uc001oiz.1_Missense_Mutation_p.E99Q	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	99	RRM 2.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		AGCCAAGTTTGAGGAGTATGG	0.512													57	164					0	0	0	0	C	66407477	C	C	66407477	3	2	284	1	0	0	0	0	1	0	0	0	13199	1291	45	2	297	2	RBM4	11	66407477	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	270493	66407477	68599039	125	52757											
NUDT8	254552	broad.mit.edu	37	chr11	67395432	67395432	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgtcaaagacctttattCagtcctggagtggagctggc	9	11	12	9	0	2	1	2	0	0	1	3	3	3	3	2	3	2	2	2	3	2	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:67395432C>T	uc001omo.1	-	4	715	c.696G>A	c.(694-696)CTG>CTA	p.L232L	NUDT8_uc001omn.2_3'UTR	NM_181843	NP_862826	Q8WV74	NUDT8_HUMAN	nudix-type motif 8	232						mitochondrion	hydrolase activity|metal ion binding				0						GACCTTTATTCAGTCCTGGAG	0.642													6	28					0	0	0	0	T	67395432	T	T	67395432	2	4	284	1	0	0	0	0	0	0	0	1	10799	841	29	2		2	NUDT8	11	67395432	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	987955	67395432	67611084	126	52758											
ORAOV1	220064	broad.mit.edu	37	chr11	69486560	69486560	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcagtagacatttccatgCaaaagcaaaaccttggtagc	14	9	9	9	0	0	1	0	0	0	1	1	1	1	1	2	1	5	5	2	1	6	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:69486560C>G	uc001opc.2	-	3	342	c.184G>C	c.(184-186)GCA>CCA	p.A62P	ORAOV1_uc010rqi.1_Missense_Mutation_p.A62P|ORAOV1_uc009ysm.2_Intron|ORAOV1_uc001opd.2_Intron|ORAOV1_uc001ope.1_Missense_Mutation_p.A62P	NM_153451	NP_703152	Q8WV07	ORAV1_HUMAN	oral cancer overexpressed 1	62											0	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;5.64e-57)|all cancers(3;5.98e-51)|BRCA - Breast invasive adenocarcinoma(2;5.49e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			CATTTCCATGCAAAAGCAAAA	0.368													15	413					0	0	0	0	G	69486560	G	G	69486560	3	3	284	1	0	0	0	0	1	0	0	0	11314	710	25	4	241	4	ORAOV1	11	69486560	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	2091128	69486560	65519956	127	52759											
ANO1	55107	broad.mit.edu	37	chr11	70031712	70031712	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcaggtataaagactaccgaGagccgccgtggtcggaaaac	13	5	13	10	4	0	2	0	0	0	2	1	4	0	3	3	3	3	2	3	3	6	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:70031712G>C	uc001opj.2	+	25	2910	c.2605G>C	c.(2605-2607)GAG>CAG	p.E869Q	ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.E578Q|ANO1_uc010rql.1_Missense_Mutation_p.E43Q	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	869	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						AGACTACCGAGAGCCGCCGTG	0.617													15	220					0	0	0	0	C	70031712	C	C	70031712	3	2	284	1	0	0	0	0	1	0	0	0	695	943	33	2	2703	2	ANO1	11	70031712	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	545152	70031712	64974804	128	52760											
MYO7A	4647	broad.mit.edu	37	chr11	76872097	76872097	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctccctcccaggatgtgAagaactctcgcaggtccatc	9	8	9	15	1	1	2	0	1	1	1	6	3	4	3	4	2	2	1	4	2	2	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:76872097A>T	uc001oyb.2	+	12	1551	c.1279A>T	c.(1279-1281)AAG>TAG	p.K427*	MYO7A_uc010rsl.1_Nonsense_Mutation_p.K427*|MYO7A_uc010rsm.1_Nonsense_Mutation_p.K416*|MYO7A_uc001oyc.2_Nonsense_Mutation_p.K427*	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	427	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCAGGATGTGAAGAACTCTCG	0.542													8	20					0	0	0	0	T	76872097	T	T	76872097	4	4	284	1	0	0	0	0	0	1	0	0	10135	247	9	5	1321	5	MYO7A	11	76872097	Nonsense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	6840385	76872097	58134419	129	52761											
USP35	57558	broad.mit.edu	37	chr11	77911809	77911809	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cactgcatggtgttccggttCccgggcttcccggatctgta	4	12	12	13	3	1	0	0	0	1	0	4	1	4	1	3	4	1	5	3	4	1	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:77911809C>T	uc009yva.1	+	6	1398	c.1152C>T	c.(1150-1152)TTC>TTT	p.F384F	USP35_uc001oze.2_Silent_p.F140F|USP35_uc001ozc.2_Intron|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_5'UTR|USP35_uc001ozf.2_Silent_p.F115F	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	384					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			TGTTCCGGTTCCCGGGCTTCC	0.622													5	26					0	0	0	0	T	77911809	T	T	77911809	2	4	284	1	0	0	0	0	0	0	0	1	17134	854	30	2		2	USP35	11	77911809	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	1039712	77911809	57094707	130	52762											
VSIG2	23584	broad.mit.edu	37	chr11	124618357	124618357	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggaacctgaccaggcagaaCgcagcaactgacagcaacag	15	3	11	12	1	0	3	0	2	0	1	0	4	0	4	2	2	6	4	2	2	4	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr11:124618357C>T	uc001qas.2	-	6	856	c.780G>A	c.(778-780)GCG>GCA	p.A260A	VSIG2_uc001qat.2_Silent_p.A260A	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	260	Helical; (Potential).					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		CCAGGCAGAACGCAGCAACTG	0.607													33	48					0	0	0	0	T	124618357	T	T	124618357	2	4	284	1	0	0	0	0	0	0	0	1	17292	523	19	1		1	VSIG2	11	124618357	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	46706548	124618357	10388159	131	52763											
KDM5A	5927	broad.mit.edu	37	chr12	463358	463358	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acacaaaagcaatttatcttCattgtttccccgaccacaaa	15	11	3	12	1	2	0	1	0	1	0	3	1	3	0	3	0	1	2	3	0	5	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:463358C>T	uc001qif.1	-	8	1276	c.913G>A	c.(913-915)GAA>AAA	p.E305K	KDM5A_uc001qie.1_Missense_Mutation_p.E305K|KDM5A_uc010sdn.1_Missense_Mutation_p.E264K|KDM5A_uc010sdo.1_Intron	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	305	PHD-type 1.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						AATTTATCTTCATTGTTTCCC	0.313			T 	NUP98	AML								8	39					0	0	0	0	T	463358	T	T	463358	3	4	284	1	0	0	0	0	1	0	0	0	8172	835	29	2	4243	2	KDM5A	12	463358	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08		463358	133388537	132	52764											
CD163L1	283316	broad.mit.edu	37	chr12	7522052	7522052	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgactcatttcctttgcaccGcatgtcatccaaccagatgg	9	12	7	13	1	2	2	2	1	0	1	4	2	4	2	4	1	2	2	4	1	1	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:7522052G>A	uc001qsy.2	-	15	3966	c.3940C>T	c.(3940-3942)CGG>TGG	p.R1314W	CD163L1_uc010sge.1_Missense_Mutation_p.R1324W	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1314	SRCR 12.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CCTTTGCACCGCATGTCATCC	0.572													4	93					0	0	0	0	A	7522052	A	A	7522052	3	1	284	1	0	0	0	0	1	0	0	0	2983	1086	38	1	441	1	CD163L1	12	7522052	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	7058694	7522052	126329843	133	52765											
DDX11	1663	broad.mit.edu	37	chr12	31255240	31255241	+	Frame_Shift_Ins	INS	-	T	T																															gctggcatattccaggtgcaINStccaggtgcgggcgtcatgc																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:31255240_31255241insT	uc001rjt.1	+	22	2517_2518	c.2266_2267insT	c.(2266-2268)ATCfs	p.I756fs	DDX11_uc001rjr.1_Frame_Shift_Ins_p.I756fs|DDX11_uc001rjs.1_Frame_Shift_Ins_p.I706fs|DDX11_uc001rju.1_Frame_Shift_Ins_p.I428fs|DDX11_uc001rjv.1_Frame_Shift_Ins_p.I756fs|DDX11_uc001rjw.1_Frame_Shift_Ins_p.I730fs|DDX11_uc009zjn.1_RNA|DDX11_uc009zjo.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	756					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					TTCCAGGTGCATCCAGGTGCGG	0.559										Multiple Myeloma(12;0.14)			---	---	---								T	31255241	T	T	31255240	7	5	284	1	0	1	1	0	0	0	0	0	4360	217	8	0	2348	0	DDX11	12	31255240	Frame_Shift_Ins	INS	-	TCGA-DQ-5625-01A-01D-1870-08	23733188	31255240	102596655	134	52766											
BICD1	636	broad.mit.edu	37	chr12	32490488	32490488	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagacagttagcagctgcaGaggatgagaagaagactctg	15	6	14	6	0	1	5	0	1	1	5	1	8	1	6	0	1	3	4	0	1	3	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:32490488G>C	uc001rku.2	+	7	2389	c.2308G>C	c.(2308-2310)GAG>CAG	p.E770Q	BICD1_uc001rkv.2_Missense_Mutation_p.E770Q|BICD1_uc010skd.1_RNA|BICD1_uc001rkw.1_Missense_Mutation_p.E52Q	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	770	Potential.|Interacts with RAB6A.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			AGCAGCTGCAGAGGATGAGAA	0.463													10	39					0	0	0	0	C	32490488	C	C	32490488	3	2	284	1	0	0	0	0	1	0	0	0	1431	943	33	2	2334	2	BICD1	12	32490488	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	1235248	32490488	101361407	135	52767											
RACGAP1	29127	broad.mit.edu	37	chr12	50388028	50388028	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatatcatccactttgctgaGgaggggtacagttttcactc	9	13	10	9	0	2	1	2	1	0	0	4	3	3	2	1	3	2	3	1	3	2	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:50388028G>C	uc001rvt.2	-	14	1535	c.1225C>G	c.(1225-1227)CTC>GTC	p.L409V	RACGAP1_uc009zlm.1_Missense_Mutation_p.L409V|RACGAP1_uc001rvs.2_Missense_Mutation_p.L409V|RACGAP1_uc001rvu.2_Missense_Mutation_p.L409V	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	409	Rho-GAP.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						ACTTTGCTGAGGAGGGGTACA	0.438													26	91					0	0	0	0	C	50388028	C	C	50388028	3	2	284	1	0	0	0	0	1	0	0	0	13042	1000	35	4	697	4	RACGAP1	12	50388028	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	17897540	50388028	83463867	136	52768											
TMPRSS12	283471	broad.mit.edu	37	chr12	51279041	51279041	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gttaacaggtaacgctacaaAtattttacaagatgcagaag	17	10	8	6	1	0	2	0	0	0	2	0	2	0	2	0	1	5	4	0	1	8	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:51279041A>T	uc001rwx.3	+	4	712	c.665A>T	c.(664-666)AAT>ATT	p.N222I	TMPRSS12_uc001rwy.2_Missense_Mutation_p.N222I	NM_182559	NP_872365	Q86WS5	TMPSC_HUMAN	transmembrane protease, serine 12 precursor	222	Peptidase S1.|Extracellular (Potential).				proteolysis	integral to membrane	serine-type endopeptidase activity				0						AACGCTACAAATATTTTACAA	0.328													20	85					0	0	0	0	T	51279041	T	T	51279041	3	4	284	1	0	0	0	0	1	0	0	0	16310	101	4	5	679	5	TMPRSS12	12	51279041	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	891013	51279041	82572854	137	52769											
RARG	5916	broad.mit.edu	37	chr12	53605612	53605612	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	taagggaggcatcgggcctgGaatctccatcttcagagtaa	11	9	12	9	1	3	1	1	0	2	1	5	3	3	3	2	4	0	2	2	4	3	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:53605612G>C	uc001sce.2	-	10	1698	c.1213C>G	c.(1213-1215)CCA>GCA	p.P405A	RARG_uc001scd.2_Missense_Mutation_p.P394A|RARG_uc010sob.1_Missense_Mutation_p.P383A|RARG_uc001scf.2_Missense_Mutation_p.P405A|RARG_uc001scg.2_Missense_Mutation_p.P333A|RARG_uc010soc.1_Missense_Mutation_p.P284A	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	405	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	ATCGGGCCTGGAATCTCCATC	0.547													19	61					0	0	0	0	C	53605612	C	C	53605612	3	2	284	1	0	0	0	0	1	0	0	0	13119	1174	41	2	155	2	RARG	12	53605612	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	2326571	53605612	80246283	138	52770											
SHMT2	6472	broad.mit.edu	37	chr12	57627425	57627425	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcagatgccctgctagagcGaggctactcactggtatcag	9	8	13	11	1	2	2	2	0	0	2	2	3	2	2	1	3	4	4	1	3	3	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:57627425G>A	uc001snf.1	+	9	1113	c.1103G>A	c.(1102-1104)CGA>CAA	p.R368Q	SHMT2_uc001sng.1_Missense_Mutation_p.R264Q|SHMT2_uc001snh.1_Missense_Mutation_p.R207Q|SHMT2_uc009zpk.1_Missense_Mutation_p.R358Q|SHMT2_uc001sni.1_Missense_Mutation_p.R347Q|SHMT2_uc010srg.1_Missense_Mutation_p.R377Q|SHMT2_uc001snj.1_Missense_Mutation_p.R272Q|SHMT2_uc010srh.1_Missense_Mutation_p.R347Q|SHMT2_uc001snk.1_Missense_Mutation_p.R272Q|SHMT2_uc010sri.1_Missense_Mutation_p.R347Q|SHMT2_uc001snl.2_Missense_Mutation_p.R272Q|SHMT2_uc010srj.1_Missense_Mutation_p.R23Q	NM_005412	NP_005403	P34897	GLYM_HUMAN	serine hydroxymethyltransferase 2	368						microtubule cytoskeleton|mitochondrial nucleoid	glycine hydroxymethyltransferase activity|methyltransferase activity			ovary(1)|central_nervous_system(1)	2					Glycine(DB00145)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CTGCTAGAGCGAGGCTACTCA	0.587													7	34					0	0	0	0	A	57627425	A	A	57627425	3	1	284	1	0	0	0	0	1	0	0	0	14351	1058	37	1	1137	1	SHMT2	12	57627425	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	4021813	57627425	76224470	139	52771											
PTPRB	5787	broad.mit.edu	37	chr12	70964817	70964817	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacattacctgtgaagcccTcaatgaaggctgactgctgt	10	11	9	11	0	2	3	2	3	0	0	2	3	2	3	2	1	3	2	2	1	4	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:70964817T>C	uc001swb.3	-	11	2735	c.2705A>G	c.(2704-2706)GAG>GGG	p.E902G	PTPRB_uc010sto.1_Missense_Mutation_p.E902G|PTPRB_uc010stp.1_Missense_Mutation_p.E812G|PTPRB_uc001swc.3_Missense_Mutation_p.E1120G|PTPRB_uc001swa.3_Missense_Mutation_p.E1032G|PTPRB_uc001swd.3_Missense_Mutation_p.E1119G|PTPRB_uc009zrr.1_Missense_Mutation_p.E999G	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	902	Fibronectin type-III 10.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGTGAAGCCCTCAATGAAGGC	0.443													3	44					0	0	0	0	C	70964817	C	C	70964817	3	2	284	1	0	0	0	0	1	0	0	0	12861	1551	54	5	3376	5	PTPRB	12	70964817	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	13337392	70964817	62887078	140	52772											
BBS10	79738	broad.mit.edu	37	chr12	76740543	76740543	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taaagcatcctcatgttgttCaatgagaccatgcactggtc	11	12	8	10	0	2	1	2	1	0	1	4	2	3	1	2	1	2	4	2	1	3	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:76740543C>T	uc001syd.1	-	2	1306	c.1222G>A	c.(1222-1224)GAA>AAA	p.E408K		NM_024685	NP_078961	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	408					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			ovary(1)|skin(1)	2						TCATGTTGTTCAATGAGACCA	0.368									Bardet-Biedl_syndrome				17	43					0	0	0	0	T	76740543	T	T	76740543	3	4	284	1	0	0	0	0	1	0	0	0	1338	835	29	2	953	2	BBS10	12	76740543	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	5775726	76740543	57111352	141	52773											
ANO4	121601	broad.mit.edu	37	chr12	101510524	101510524	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgactttgagaaccgatctGagcctgaatctgatggcagt	10	11	11	9	1	2	5	0	5	2	1	2	7	2	5	2	1	2	1	2	1	2	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:101510524G>A	uc010svm.1	+	25	3090	c.2518G>A	c.(2518-2520)GAG>AAG	p.E840K	ANO4_uc001thw.2_Missense_Mutation_p.E805K|ANO4_uc001thx.2_Missense_Mutation_p.E840K|ANO4_uc001thy.2_Missense_Mutation_p.E360K	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	840	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GAACCGATCTGAGCCTGAATC	0.512										HNSCC(74;0.22)			23	93					0	0	0	0	A	101510524	A	A	101510524	3	1	284	1	0	0	0	0	1	0	0	0	699	1291	45	2	2503	2	ANO4	12	101510524	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	24769981	101510524	32341371	142	52774											
ALKBH2	121642	broad.mit.edu	37	chr12	109526080	109526080	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagaaccttctttctcacGggaagactgtggtaccagtg	9	10	11	11	1	2	2	1	0	2	2	3	3	2	3	3	2	2	1	3	2	3	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:109526080G>T	uc001tnx.2	-	4	1110	c.717C>A	c.(715-717)CCC>CCA	p.P239P	ALKBH2_uc001tny.2_Silent_p.P239P|ALKBH2_uc010sxj.1_Silent_p.P239P|ALKBH2_uc009zvd.2_3'UTR|ALKBH2_uc010sxk.1_3'UTR	NM_001145374	NP_001138846	Q6NS38	ALKB2_HUMAN	AlkB homolog 2	239	Fe2OG dioxygenase.				DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	TCTTTCTCACGGGAAGACTGT	0.483								Direct_reversal_of_damage					4	138					0.00909568	0.0092673	1	0	T	109526080	T	T	109526080	2	4	284	1	0	0	0	0	0	0	0	1	527	1103	39	3		3	ALKBH2	12	109526080	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	8015556	109526080	24325815	143	52775											
CLIP1	6249	broad.mit.edu	37	chr12	122825752	122825752	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgtgttggtaatctagtcTcattttctctatttgtgttt	5	23	7	6	1	3	0	1	0	3	0	6	0	3	0	0	1	0	3	0	1	3	9			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:122825752T>G	uc001ucg.1	-	10	2105	c.1999A>C	c.(1999-2001)AGA>CGA	p.R667R	CLIP1_uc001uch.1_Silent_p.R656R|CLIP1_uc001uci.1_Silent_p.R621R|CLIP1_uc001ucj.1_Silent_p.R357R|CLIP1_uc009zxo.1_Silent_p.R223R	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	667	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TAATCTAGTCTCATTTTCTCT	0.433													35	119					0	0	0	0	G	122825752	G	G	122825752	2	3	284	1	0	0	0	0	0	0	0	1	3547	1559	54	5		5	CLIP1	12	122825752	Silent	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	13299672	122825752	11026143	144	52776											
GOLGA3	2802	broad.mit.edu	37	chr12	133363026	133363026	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagggcctcctgcaggcggcGgctgaggatgcccacggcgt	5	5	18	13	4	0	1	0	1	0	0	1	3	1	2	3	6	2	2	3	6	0	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr12:133363026G>A	uc001ukz.1	-	15	3581	c.3022C>T	c.(3022-3024)CGC>TGC	p.R1008C	GOLGA3_uc001ula.1_Missense_Mutation_p.R1008C|GOLGA3_uc001ulb.2_Missense_Mutation_p.R1008C	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1008	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TGCAGGCGGCGGCTGAGGATG	0.657													9	13					0	0	0	0	A	133363026	A	A	133363026	3	1	284	1	0	0	0	0	1	0	0	0	6591	1116	39	1	1652	1	GOLGA3	12	133363026	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	10537274	133363026	488869	145	52777											
PARP4	143	broad.mit.edu	37	chr13	25008562	25008562	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagactgaggagttctgtccAaggcacagcatcctgccagt	10	9	11	11	0	1	2	0	1	1	1	3	3	3	3	3	2	2	3	3	2	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr13:25008562A>G	uc001upl.2	-	31	4823	c.4717T>C	c.(4717-4719)TGG>CGG	p.W1573R		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1573	Interaction with the major vault protein.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		AGTTCTGTCCAAGGCACAGCA	0.423													14	60					0	0	0	0	G	25008562	G	G	25008562	3	3	284	1	0	0	0	0	1	0	0	0	11517	130	5	5	473	5	PARP4	13	25008562	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08		25008562	90161316	146	52778											
B3GALTL	145173	broad.mit.edu	37	chr13	31821997	31821997	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttcttttggtcagtttttCtgtaacatatagcagaaatt	10	19	7	5	0	3	1	1	0	2	1	3	1	3	1	0	1	2	4	0	1	4	9			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr13:31821997C>G	uc010aaz.2	+	6	463	c.353C>G	c.(352-354)TCT>TGT	p.S118C		NM_194318	NP_919299	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	118	Lumenal (Potential).				fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		GTCAGTTTTTCTGTAACATAT	0.338													6	14					0	0	0	0	G	31821997	G	G	31821997	3	3	284	1	0	0	0	0	1	0	0	0	1254	913	32	2	375	2	B3GALTL	13	31821997	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	6813435	31821997	83347881	147	52779											
ZIC2	7546	broad.mit.edu	37	chr13	100635121	100635121	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgaccccgagcaactgagcaAtcccaagaagagctgcaaca	15	3	9	14	2	0	3	0	1	0	2	1	5	1	3	3	0	6	4	3	0	5	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr13:100635121A>G	uc001von.2	+	1	803	c.803A>G	c.(802-804)AAT>AGT	p.N268S		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	268	C2H2-type 1; atypical.				brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAACTGAGCAATCCCAAGAAG	0.532													24	92					0	0	0	0	G	100635121	G	G	100635121	3	3	284	1	0	0	0	0	1	0	0	0	17746	101	4	5	805	5	ZIC2	13	100635121	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	68813124	100635121	14534757	148	52780											
NEDD8	4738	broad.mit.edu	37	chr14	24686415	24686415	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatcttgtaatcagctgctGtcttctcatcattcctgcag	9	15	6	11	0	5	0	3	0	3	0	7	0	6	0	1	0	3	4	1	0	2	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr14:24686415G>C	uc001wnn.2	-	4	267	c.164C>G	c.(163-165)ACA>AGA	p.T55R	CHMP4A_uc001wnj.2_5'Flank|MDP1_uc001wnk.1_5'Flank|CHMP4A_uc001wnm.1_5'Flank|MDP1_uc001wnl.1_5'Flank|NEDD8_uc001wno.2_RNA	NM_006156	NP_006147	Q15843	NEDD8_HUMAN	neural precursor cell expressed, developmentally	55					anatomical structure morphogenesis|protein neddylation|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin protein ligase binding				0				GBM - Glioblastoma multiforme(265;0.0186)		ATCAGCTGCTGTCTTCTCATC	0.368													14	30					0	0	0	0	C	24686415	C	C	24686415	3	2	284	1	0	0	0	0	1	0	0	0	10366	1377	48	4	85	4	NEDD8	14	24686415	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		24686415	82663125	149	52781											
MDGA2	161357	broad.mit.edu	37	chr14	47504314	47504314	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgacatttccctagatacAttcacaatcctcagtgttcc	10	13	4	14	0	2	2	2	1	0	1	5	2	5	2	4	0	1	1	4	0	3	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr14:47504314A>C	uc001wwj.3	-	8	1708	c.1512T>G	c.(1510-1512)AAT>AAG	p.N504K	MDGA2_uc001wwi.3_Missense_Mutation_p.N275K|MDGA2_uc010ani.2_Missense_Mutation_p.N64K	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	504	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CCCTAGATACATTCACAATCC	0.428													23	122					0	0	0	0	C	47504314	C	C	47504314	3	2	284	1	0	0	0	0	1	0	0	0	9460	214	8	5	1398	5	MDGA2	14	47504314	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	22817899	47504314	59845226	150	52782											
SOS2	6655	broad.mit.edu	37	chr14	50597372	50597372	+	Missense_Mutation	SNP	C	T	T																															aaagcttattttacatggttCtctttctaatggtgttgggt																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr14:50597372C>T	uc001wxs.3	-	20	3282	c.3184G>A	c.(3184-3186)GAA>AAA	p.E1062K	SOS2_uc010ans.2_5'UTR|SOS2_uc010tql.1_Missense_Mutation_p.E1029K	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1062					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					TTACATGGTTCTCTTTCTAAT	0.438													15	77					0	0	0	0	T	50597372	T	T	50597372	3	4	284	1	0	0	0	0	1	0	0	0	15001	922	32	2	830	2	SOS2	14	50597372	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	3093058	50597372	56752168	151	52783	120	2									
SOS2	6655	broad.mit.edu	37	chr14	50597378	50597378	+	Missense_Mutation	SNP	C	T	T																															tattttacatggttctctttCtaatggtgttgggtgacctc																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr14:50597378C>T	uc001wxs.3	-	20	3276	c.3178G>A	c.(3178-3180)GAA>AAA	p.E1060K	SOS2_uc010ans.2_5'UTR|SOS2_uc010tql.1_Missense_Mutation_p.E1027K	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1060					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					GGTTCTCTTTCTAATGGTGTT	0.438													16	74					0	0	0	0	T	50597378	T	T	50597378	3	4	284	1	0	0	0	0	1	0	0	0	15001	922	32	2	836	2	SOS2	14	50597378	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	6	50597378	56752162	152	52784	120	2									
C14orf50	145376	broad.mit.edu	37	chr14	65041274	65041274	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tatccttgtgctgggcttggCcgtgccggataagcatcaca	7	11	12	11	2	1	0	1	0	0	0	2	1	2	1	3	3	3	3	3	3	2	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr14:65041274C>T	uc001xhl.1	+	8	731	c.635C>T	c.(634-636)GCC>GTC	p.A212V		NM_172365	NP_758953	Q96LQ0	CN050_HUMAN	hypothetical protein LOC145376	212										skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00382)|all cancers(60;0.00427)|BRCA - Breast invasive adenocarcinoma(234;0.0488)		CTGGGCTTGGCCGTGCCGGAT	0.438													4	105					0	0	0	0	T	65041274	T	T	65041274	3	4	284	1	0	0	0	0	1	0	0	0	1783	739	26	4	665	4	C14orf50	14	65041274	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	14443896	65041274	42308266	153	52785											
NRXN3	9369	broad.mit.edu	37	chr14	79175742	79175742	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtggaacactaaacgtatGggctccatctcctttgactt	11	12	8	10	1	1	1	0	1	1	0	3	2	2	2	2	2	2	2	2	2	5	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr14:79175742G>T	uc001xun.2	+	4	776	c.285G>T	c.(283-285)ATG>ATT	p.M95I	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.M229I	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	468	Extracellular (Potential).|Laminin G-like 3.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CTAAACGTATGGGCTCCATCT	0.517													16	73					6.31663e-08	6.66207e-08	1	0	T	79175742	T	T	79175742	3	4	284	1	0	0	0	0	1	0	0	0	10721	1348	47	4	291	4	NRXN3	14	79175742	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	14134468	79175742	28173798	154	52786											
DICER1	23405	broad.mit.edu	37	chr14	95596530	95596530	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagcaagtcataatgagaacCtaaaataaaatcaacatcag	21	8	5	7	0	3	1	3	1	0	1	3	2	3	1	1	0	3	1	1	0	9	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr14:95596530C>T	uc001ydw.2	-	6	621	c.439_splice	c.e6-1	p.V147_splice	DICER1_uc001ydv.2_Splice_Site_p.V137_splice|DICER1_uc001ydx.2_Splice_Site_p.V147_splice	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1						negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TAATGAGAACCTAAAATAAAA	0.333			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				4	20					0	0	0	0	T	95596530	T	T	95596530	5	4	284	1	0	0	0	0	0	0	1	0	4543	695	24	4	5422	4	DICER1	14	95596530	Splice_Site	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	16420788	95596530	11753010	155	52787											
ATP10A	57194	broad.mit.edu	37	chr15	25924588	25924588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggacaggaagtccacgtcccGcttgtccatctgcaagctgc	8	8	11	14	2	1	0	0	0	1	0	4	2	4	2	3	2	3	3	3	2	2	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr15:25924588G>A	uc010ayu.2	-	21	4506	c.4400C>T	c.(4399-4401)GCG>GTG	p.A1467V		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1467	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TCCACGTCCCGCTTGTCCATC	0.567													10	40					0	0	0	0	A	25924588	A	A	25924588	3	1	284	1	0	0	0	0	1	0	0	0	1118	1087	38	1	103	1	ATP10A	15	25924588	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		25924588	76606804	156	52788											
SERF2	10169	broad.mit.edu	37	chr15	44085227	44085227	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatgaaaaagcagagcgactCggttaagggaaagcgccgag	15	5	14	7	4	0	2	0	1	0	1	1	5	0	3	1	2	3	2	1	2	5	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr15:44085227C>T	uc001zsz.3	+	2	160	c.62C>T	c.(61-63)TCG>TTG	p.S21L	ELL3_uc001zsx.1_Intron|SERF2_uc010bdq.2_Missense_Mutation_p.S21L|SERF2_uc010uee.1_5'UTR|C15orf63_uc001ztb.2_5'UTR	NM_001018108	NP_001018118	P84101	SERF2_HUMAN	small EDRK-rich factor 2	21						cytosol|nucleus					0		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		CAGAGCGACTCGGTTAAGGGA	0.597													6	24					0	0	0	0	T	44085227	T	T	44085227	3	4	284	1	0	0	0	0	1	0	0	0	14141	893	31	1	68	1	SERF2	15	44085227	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	18160639	44085227	58446165	157	52789											
SQRDL	58472	broad.mit.edu	37	chr15	45962152	45962152	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccgatatcttattattgcTctcggaatccagctggacta	10	14	7	10	2	2	0	0	0	2	0	4	3	3	2	2	2	3	2	2	2	6	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr15:45962152T>G	uc001zvt.2	+	5	621	c.432T>G	c.(430-432)GCT>GCG	p.A144A	SQRDL_uc001zvu.2_Silent_p.A144A|SQRDL_uc001zvv.2_Silent_p.A144A	NM_021199	NP_067022	Q9Y6N5	SQRD_HUMAN	sulfide dehydrogenase like precursor	144							oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		TTATTATTGCTCTCGGAATCC	0.433													27	156					0	0	0	0	G	45962152	G	G	45962152	2	3	284	1	0	0	0	0	0	0	0	1	15195	1538	54	5		5	SQRDL	15	45962152	Silent	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	1876925	45962152	56569240	158	52790											
RASGRF1	5923	broad.mit.edu	37	chr15	79339164	79339164	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcggccatccgcagcgggcGcaggaaattgttgacaagga	10	5	16	10	4	0	1	0	1	0	0	1	3	1	3	2	5	1	3	2	5	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr15:79339164G>A	uc002beq.2	-	5	1177	c.802C>T	c.(802-804)CGC>TGC	p.R268C	RASGRF1_uc002bep.2_Missense_Mutation_p.R268C|RASGRF1_uc010blm.1_Missense_Mutation_p.R190C|RASGRF1_uc002ber.3_Missense_Mutation_p.R268C	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	268	DH.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						CGCAGCGGGCGCAGGAAATTG	0.587													13	75					0	0	0	0	A	79339164	A	A	79339164	3	1	284	1	0	0	0	0	1	0	0	0	13137	1087	38	1	3115	1	RASGRF1	15	79339164	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	33377012	79339164	23192228	159	52791											
IL16	3603	broad.mit.edu	37	chr15	81598343	81598343	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caacggcaagtctctcaaggGgaccacgcaccatgatgcct	11	6	10	14	2	2	1	1	1	1	0	3	2	2	2	3	3	2	2	3	3	3	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr15:81598343G>A	uc002bgh.3	+	17	3891	c.3515G>A	c.(3514-3516)GGG>GAG	p.G1172E	IL16_uc010blq.1_Missense_Mutation_p.G1126E|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.G1214E|IL16_uc002bgg.2_Missense_Mutation_p.G1172E|IL16_uc002bgi.1_Missense_Mutation_p.G562E|IL16_uc002bgj.2_Missense_Mutation_p.G666E|IL16_uc002bgk.2_Missense_Mutation_p.G471E|IL16_uc002bgl.1_Missense_Mutation_p.G471E|IL16_uc010unq.1_Missense_Mutation_p.G471E	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	1172	PDZ 3.|Interaction with PPP1R12A, PPP1R12B and PPP1R12C.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						TCTCTCAAGGGGACCACGCAC	0.567													38	152					0	0	0	0	A	81598343	A	A	81598343	3	1	284	1	0	0	0	0	1	0	0	0	7672	1232	43	4	3577	4	IL16	15	81598343	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	2259179	81598343	20933049	160	52792											
SH3GL3	6457	broad.mit.edu	37	chr15	84241361	84241361	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatccatgaagctaatggctGaggtgaaagactctcttgat	13	11	10	7	0	1	5	0	4	1	1	3	5	2	5	1	2	1	2	1	2	4	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr15:84241361G>A	uc002bjw.2	+	5	571	c.376G>A	c.(376-378)GAG>AAG	p.E126K	SH3GL3_uc010uot.1_Missense_Mutation_p.E126K|SH3GL3_uc002bjx.2_Missense_Mutation_p.E57K|SH3GL3_uc002bju.2_Missense_Mutation_p.E134K|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	126	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						GCTAATGGCTGAGGTGAAAGA	0.353													10	54					0	0	0	0	A	84241361	A	A	84241361	3	1	284	1	0	0	0	0	1	0	0	0	14317	1291	45	2	394	2	SH3GL3	15	84241361	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	2643018	84241361	18290031	161	52793											
CHSY1	22856	broad.mit.edu	37	chr15	101791398	101791398	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggcggtcatgactcccacGaagagaaagttcctgtcgcg	9	8	13	11	4	1	2	1	1	0	1	4	4	3	2	2	2	0	1	2	2	2	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr15:101791398G>A	uc002bwt.1	-	2	747	c.264C>T	c.(262-264)TTC>TTT	p.F88F		NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	88	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGACTCCCACGAAGAGAAAGT	0.572													5	8					0	0	0	0	A	101791398	A	A	101791398	2	1	284	1	0	0	0	0	0	0	0	1	3427	1049	37	1		1	CHSY1	15	101791398	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	17550037	101791398	739994	162	52794											
USP7	7874	broad.mit.edu	37	chr16	8989591	8989591	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gattttgtagcttacaatttCtagcagcctgaacagagagg	12	12	10	7	0	1	2	0	1	1	1	1	4	1	2	1	1	5	3	1	1	5	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr16:8989591C>G	uc002czl.2	-	27	3026	c.2827G>C	c.(2827-2829)GAA>CAA	p.E943Q	USP7_uc010uyk.1_Missense_Mutation_p.E844Q|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.E844Q|USP7_uc002czk.2_Missense_Mutation_p.E927Q	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	943					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						CTTACAATTTCTAGCAGCCTG	0.333													17	24					0	0	0	0	G	8989591	G	G	8989591	3	3	284	1	0	0	0	0	1	0	0	0	17156	922	32	2	501	2	USP7	16	8989591	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08		8989591	81365162	163	52795											
IGSF6	10261	broad.mit.edu	37	chr16	21654396	21654396	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgacattttacacttacaGattgctgatttgtttccaca	10	18	5	8	0	0	3	0	2	0	1	1	3	1	3	1	0	3	2	1	0	2	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr16:21654396G>A	uc002djg.1	-	5	718	c.665C>T	c.(664-666)TCT>TTT	p.S222F	uc002diq.3_Intron|METTL9_uc002dje.2_Intron|METTL9_uc002djf.2_Intron	NM_005849	NP_005840	O95976	IGSF6_HUMAN	immunoglobulin superfamily, member 6 precursor	222	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0				GBM - Glioblastoma multiforme(48;0.066)		TACACTTACAGATTGCTGATT	0.338													44	62					0	0	0	0	A	21654396	A	A	21654396	3	1	284	1	0	0	0	0	1	0	0	0	7642	956	33	2	68	2	IGSF6	16	21654396	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	12664805	21654396	68700357	164	52796											
ZNF423	23090	broad.mit.edu	37	chr16	49764853	49764853	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcgcacggctggttttctGatcgcactctggctctcctt	4	13	10	14	3	3	1	0	1	3	0	5	1	3	1	1	3	1	5	1	3	0	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr16:49764853G>C	uc002efs.2	-	4	404	c.106C>G	c.(106-108)CAG>GAG	p.Q36E		NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	36					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CTGGTTTTCTGATCGCACTCT	0.498													45	181					0	0	0	0	C	49764853	C	C	49764853	3	2	284	1	0	0	0	0	1	0	0	0	17965	1299	45	2	3772	2	ZNF423	16	49764853	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	28110457	49764853	40589900	165	52797											
SALL1	6299	broad.mit.edu	37	chr16	51172806	51172806	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaagacagaggcccagaCgggacgtgactggtgggggt	10	4	20	7	2	0	4	0	1	0	3	0	7	0	6	1	6	0	0	1	6	1	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr16:51172806C>T	uc010vgs.1	-	2	3358	c.3327G>A	c.(3325-3327)CCG>CCA	p.P1109P	SALL1_uc010vgr.1_Silent_p.P1012P|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1109					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GAGGCCCAGACGGGACGTGAC	0.562													19	33					0	0	0	0	T	51172806	T	T	51172806	2	4	284	1	0	0	0	0	0	0	0	1	13875	523	19	1		1	SALL1	16	51172806	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	1407953	51172806	39181947	166	52798											
CNGB1	1258	broad.mit.edu	37	chr16	57953078	57953078	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaacttgcagcagagcatgtCgcaatagtgctcctcttcca	10	10	9	12	1	1	1	0	0	1	1	4	2	3	1	2	0	5	5	2	0	3	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr16:57953078C>T	uc002emt.2	-	20	1947	c.1882G>A	c.(1882-1884)GAC>AAC	p.D628N	CNGB1_uc010cdh.2_Missense_Mutation_p.D622N	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	628	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						CAGAGCATGTCGCAATAGTGC	0.577													19	37					0	0	0	0	T	57953078	T	T	57953078	3	4	284	1	0	0	0	0	1	0	0	0	3615	884	31	1	1929	1	CNGB1	16	57953078	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	6780272	57953078	32401675	167	52799											
CES2	8824	broad.mit.edu	37	chr16	66975486	66975486	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctgctggcctctgccgaCtttcagcctgtccctagcat	5	11	10	15	1	2	0	1	0	1	0	3	2	3	0	4	1	5	3	4	1	1	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr16:66975486C>G	uc002eqr.2	+	7	2185	c.1185C>G	c.(1183-1185)GAC>GAG	p.D395E	CES2_uc002eqq.2_Missense_Mutation_p.D395E|CES2_uc002eqs.2_Missense_Mutation_p.D238E	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	331					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CCTCTGCCGACTTTCAGCCTG	0.592													11	34					0	0	0	0	G	66975486	G	G	66975486	3	3	284	1	0	0	0	0	1	0	0	0	3285	564	20	4	1211	4	CES2	16	66975486	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	9022408	66975486	23379267	168	52800											
AP1G1	164	broad.mit.edu	37	chr16	71823366	71823366	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccggatcagctcccgcaatCtgatgggggctggcatcctc	6	9	12	14	2	2	1	1	1	1	0	6	2	5	2	3	4	1	4	3	4	1	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr16:71823366C>G	uc010cgg.2	-	2	331	c.17G>C	c.(16-18)AGA>ACA	p.R6T	AP1G1_uc002fba.2_Missense_Mutation_p.R6T|AP1G1_uc002fbb.2_Missense_Mutation_p.R29T|AP1G1_uc010vmg.1_RNA|AP1G1_uc010vmh.1_Missense_Mutation_p.R88T	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	6					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				CTCCCGCAATCTGATGGGGGC	0.438													15	66					0	0	0	0	G	71823366	G	G	71823366	3	3	284	1	0	0	0	0	1	0	0	0	732	913	32	2	2552	2	AP1G1	16	71823366	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	4847880	71823366	18531387	169	52801											
DHODH	1723	broad.mit.edu	37	chr16	72046112	72046112	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagactggctgttcgcttcaCctccctggggctccttccac	4	11	9	17	1	1	1	1	0	0	1	5	1	4	1	4	3	0	4	4	3	0	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr16:72046112C>A	uc002fbp.2	+	2	206	c.185C>A	c.(184-186)ACC>AAC	p.T62N	DHODH_uc010cgk.2_RNA	NM_001361	NP_001352	Q02127	PYRD_HUMAN	dihydroorotate dehydrogenase precursor	62	Mitochondrial intermembrane (By similarity).				'de novo' pyrimidine base biosynthetic process|pyrimidine nucleoside biosynthetic process|UMP biosynthetic process	integral to membrane|mitochondrial inner membrane	dihydroorotate oxidase activity				0		Ovarian(137;0.125)			Atovaquone(DB01117)|Leflunomide(DB01097)	GTTCGCTTCACCTCCCTGGGG	0.567													16	58					9.7654e-05	0.000100636	1	0	A	72046112	A	A	72046112	3	1	284	1	0	0	0	0	1	0	0	0	4506	507	18	4	191	4	DHODH	16	72046112	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	222746	72046112	18308641	170	52802											
ZFHX3	463	broad.mit.edu	37	chr16	72821072	72821072	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcttcaaagcttacaatctGaaggtgtccgttcctacact	11	13	6	11	1	3	1	1	1	2	0	5	1	5	1	2	1	3	2	2	1	5	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr16:72821072G>A	uc002fck.2	-	10	11776	c.11103C>T	c.(11101-11103)TTC>TTT	p.F3701F	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Silent_p.F2787F	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3701					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CTTACAATCTGAAGGTGTCCG	0.438													46	172					0	0	0	0	A	72821072	A	A	72821072	2	1	284	1	0	0	0	0	0	0	0	1	17701	1281	45	2		2	ZFHX3	16	72821072	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	774960	72821072	17533681	171	52803											
MINK1	50488	broad.mit.edu	37	chr17	4799024	4799024	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactgcgggtgtattacctGtcctggctccggaacaagat	10	10	11	10	2	0	1	0	0	0	1	2	2	2	2	3	3	4	2	3	3	5	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:4799024G>T	uc010vsl.1	+	27	3457	c.3261G>T	c.(3259-3261)CTG>CTT	p.L1087L	MINK1_uc010vsk.1_Silent_p.L1058L|MINK1_uc010vsm.1_Silent_p.L1067L|MINK1_uc010vsn.1_Silent_p.L1050L|MINK1_uc010vso.1_Silent_p.L995L|MINK1_uc010vsp.1_Silent_p.L548L	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	1087	Mediates interaction with RAP2A.|CNH.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						TGTATTACCTGTCCTGGCTCC	0.602													4	20					0.00024832	0.000254929	1	0	T	4799024	T	T	4799024	2	4	284	1	0	0	0	0	0	0	0	1	9640	1364	48	4		4	MINK1	17	4799024	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		4799024	76396186	172	52804											
TEKT1	83659	broad.mit.edu	37	chr17	6722633	6722633	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacaagctgctcaagtttgtCatctaactccttcttccaga	10	13	5	13	0	4	1	2	0	2	1	6	1	6	1	2	0	3	3	2	0	3	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:6722633C>T	uc002gdt.2	-	3	345	c.235G>A	c.(235-237)GAC>AAC	p.D79N	TEKT1_uc010vth.1_Intron	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	79	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				TCAAGTTTGTCATCTAACTCC	0.448													10	36					0	0	0	0	T	6722633	T	T	6722633	3	4	284	1	0	0	0	0	1	0	0	0	15818	826	29	2	1045	2	TEKT1	17	6722633	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	1923609	6722633	74472577	173	52805											
TEKT1	83659	broad.mit.edu	37	chr17	6722667	6722667	+	Silent	SNP	G	C	C																															ttccagaactggacttcctcGagtctctgttctgaagcaca																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:6722667G>C	uc002gdt.2	-	3	311	c.201C>G	c.(199-201)CTC>CTG	p.L67L	TEKT1_uc010vth.1_Intron	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	67	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				GGACTTCCTCGAGTCTCTGTT	0.408													8	24					0	0	0	0	C	6722667	C	C	6722667	2	2	284	1	0	0	0	0	0	0	0	1	15818	1045	37	3		3	TEKT1	17	6722667	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	34	6722667	74472543	174	52806	121	2									
TEKT1	83659	broad.mit.edu	37	chr17	6722673	6722673	+	Missense_Mutation	SNP	C	G	G																															aactggacttcctcgagtctCtgttctgaagcacacgggga																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:6722673C>G	uc002gdt.2	-	3	305	c.195G>C	c.(193-195)CAG>CAC	p.Q65H	TEKT1_uc010vth.1_Intron	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	65	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				CCTCGAGTCTCTGTTCTGAAG	0.418													5	24					0	0	0	0	G	6722673	G	G	6722673	3	3	284	1	0	0	0	0	1	0	0	0	15818	912	32	2	1085	2	TEKT1	17	6722673	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	6	6722673	74472537	175	52807	121	2									
YBX2	51087	broad.mit.edu	37	chr17	7192917	7192918	+	Nonsense_Mutation	DNP	GG	AA	AA																															ggcctgctgccgtctccgctGgaagtaggggcggtttcgtg																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:7192917_7192918GG>AA	uc002gfq.2	-	7	1032_1033	c.975_976CC>TT	c.(973-978)TTCCAG>TTTTAG	p.Q326*		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	326	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						CGTCTCCGCTGGAAGTAGGGGC	0.678													10	36					0	0	0	0	AA	7192918	AA	AA	7192917	4	1	284	1	0	0	0	0	0	1	0	0	17538	1357	47	4	126	4	YBX2	17	7192917	Nonsense_Mutation	DNP	GG	TCGA-DQ-5625-01A-01D-1870-08	470244	7192917	74002293	176	52808											
YBX2	51087	broad.mit.edu	37	chr17	7193599	7193599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgctggttgggaggccGggggcctcgcacaaaccgcc	5	6	16	14	3	0	0	0	0	0	0	1	1	0	1	4	5	3	4	4	5	1	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:7193599G>A	uc002gfq.2	-	5	772	c.715C>T	c.(715-717)CGG>TGG	p.R239W		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	239	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						TTGGGAGGCCGGGGGCCTCGC	0.622													39	161					0	0	0	0	A	7193599	A	A	7193599	3	1	284	1	0	0	0	0	1	0	0	0	17538	1115	39	1	395	1	YBX2	17	7193599	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	682	7193599	74001611	177	52809											
USP43	124739	broad.mit.edu	37	chr17	9631983	9631983	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggaatgagagggcagaggtCtctccacaggtgccccccgt	9	6	14	12	1	1	2	0	1	1	2	3	4	2	3	4	4	1	1	4	4	1	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:9631983C>G	uc010cod.2	+	15	3048	c.3048C>G	c.(3046-3048)GTC>GTG	p.V1016V	USP43_uc002gma.3_Silent_p.V705V|USP43_uc010vva.1_Silent_p.V1011V|USP43_uc010coe.2_Silent_p.V813V|USP43_uc002gmc.3_Silent_p.V528V	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	1016					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GGGCAGAGGTCTCTCCACAGG	0.642													9	9					0	0	0	0	G	9631983	G	G	9631983	2	3	284	1	0	0	0	0	0	0	0	1	17142	900	32	2		2	USP43	17	9631983	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	2438384	9631983	71563227	178	52810											
MYH13	8735	broad.mit.edu	37	chr17	10233795	10233795	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcgtcaccagcttctcatCtctcatctcctccaaaagtc	9	11	4	17	1	5	0	3	0	3	0	10	0	6	0	3	0	2	1	3	0	2	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:10233795C>T	uc002gmk.1	-	21	2434	c.2344G>A	c.(2344-2346)GAT>AAT	p.D782N		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	782	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						AGCTTCTCATCTCTCATCTCC	0.542													7	20					0	0	0	0	T	10233795	T	T	10233795	3	4	284	1	0	0	0	0	1	0	0	0	10085	913	32	2	3556	2	MYH13	17	10233795	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	601812	10233795	70961415	179	52811											
MYH4	4622	broad.mit.edu	37	chr17	10359162	10359162	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtttcattggggatgatgcaCcgcacaaagtgggggtgagt	9	10	16	6	1	1	2	1	2	0	0	1	3	1	3	1	4	1	3	1	4	1	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:10359162C>G	uc002gmn.2	-	18	2136	c.2025G>C	c.(2023-2025)CGG>CGC	p.R675R	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	675	Myosin head-like.|Actin-binding (By similarity).				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GGATGATGCACCGCACAAAGT	0.428													26	113					0	0	0	0	G	10359162	G	G	10359162	2	3	284	1	0	0	0	0	0	0	0	1	10090	494	18	4		4	MYH4	17	10359162	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	125367	10359162	70836048	180	52812											
MYOCD	93649	broad.mit.edu	37	chr17	12656440	12656440	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actccagcctcttggaaatgCtcattgtgtggagtcctcag	8	12	10	11	0	3	0	2	0	1	0	5	2	5	2	3	2	2	1	3	2	1	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:12656440C>G	uc002gnn.2	+	10	2134	c.1835C>G	c.(1834-1836)GCT>GGT	p.A612G	MYOCD_uc002gno.2_Missense_Mutation_p.A612G|MYOCD_uc002gnp.1_Missense_Mutation_p.A516G|MYOCD_uc002gnq.2_Missense_Mutation_p.A331G	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	612					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CTTGGAAATGCTCATTGTGTG	0.512													34	110					0	0	0	0	G	12656440	G	G	12656440	3	3	284	1	0	0	0	0	1	0	0	0	10140	797	28	4	1873	4	MYOCD	17	12656440	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	2297278	12656440	68538770	181	52813											
NEK8	284086	broad.mit.edu	37	chr17	27061083	27061083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaacagatgaccaaggaaGagcggcaggcagcccagaat	15	3	14	9	1	0	4	0	1	0	3	0	6	0	6	2	4	3	2	2	4	4	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:27061083G>A	uc002hcp.2	+	2	130	c.130G>A	c.(130-132)GAG>AAG	p.E44K		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	44	Protein kinase.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					GACCAAGGAAGAGCGGCAGGC	0.527													11	57					0	0	0	0	A	27061083	A	A	27061083	3	1	284	1	0	0	0	0	1	0	0	0	10384	943	33	2	136	2	NEK8	17	27061083	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	14404643	27061083	54134127	182	52814											
GIT1	28964	broad.mit.edu	37	chr17	27903555	27903555	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ctcacctctcgctgcagcctCcggagctcgtcgctcaggct	4	9	10	18	4	3	0	2	0	1	0	7	1	4	1	3	2	3	5	3	2	0	0	rs145208703		TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:27903555C>G	uc002hef.2	-	13	1579	c.1365G>C	c.(1363-1365)CGG>CGC	p.R455R	GIT1_uc002heg.2_Silent_p.R464R|GIT1_uc010wbg.1_Silent_p.R464R|GIT1_uc010csb.1_Silent_p.R455R	NM_014030	NP_054749	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interactor 1	455					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding				0				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		GCTGCAGCCTCCGGAGCTCGT	0.622													13	49					0	0	0	0	G	27903555	G	G	27903555	2	3	284	1	0	0	0	0	0	0	0	1	6433	842	30	2		2	GIT1	17	27903555	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	842472	27903555	53291655	183	52815											
KCNH6	81033	broad.mit.edu	37	chr17	61623093	61623093	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcagaacaggaacagcctGaggggctctggccaccccta	10	5	11	15	0	2	2	1	1	1	1	2	3	2	3	5	4	3	1	5	4	3	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:61623093G>C	uc002jay.2	+	14	2895	c.2815G>C	c.(2815-2817)GAG>CAG	p.E939Q	KCNH6_uc010wpl.1_Missense_Mutation_p.E780Q|KCNH6_uc010wpm.1_Missense_Mutation_p.E903Q|KCNH6_uc002jaz.1_Missense_Mutation_p.E850Q	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	939	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	GGAACAGCCTGAGGGGCTCTG	0.582													17	69					0	0	0	0	C	61623093	C	C	61623093	3	2	284	1	0	0	0	0	1	0	0	0	8075	1291	45	2	2869	2	KCNH6	17	61623093	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	33719538	61623093	19572117	184	52816											
EVPL	2125	broad.mit.edu	37	chr17	74003878	74003878	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggtgctctggggggccgggGaggcgagcggggacttggag	4	6	24	7	3	1	0	0	0	1	0	1	4	1	3	1	10	2	1	1	10	0	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr17:74003878G>A	uc002jqi.2	-	22	5636	c.5408C>T	c.(5407-5409)TCC>TTC	p.S1803F	EVPL_uc010wss.1_Missense_Mutation_p.S1825F|EVPL_uc010wst.1_Missense_Mutation_p.S1273F	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1803	Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						GGGGGCCGGGGAGGCGAGCGG	0.602													23	64					0	0	0	0	A	74003878	A	A	74003878	3	1	284	1	0	0	0	0	1	0	0	0	5316	1174	41	2	697	2	EVPL	17	74003878	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	12380785	74003878	7191332	185	52817											
TNFRSF11A	8792	broad.mit.edu	37	chr18	60052041	60052041	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgggcaggtgatgaactTcaagggcgacatcatcgtgg	10	7	15	9	3	2	2	2	2	0	0	3	3	2	2	0	4	2	1	0	4	2	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr18:60052041T>A	uc002lin.2	+	10	1663	c.1625T>A	c.(1624-1626)TTC>TAC	p.F542Y	TNFRSF11A_uc010dpv.2_Missense_Mutation_p.F225Y	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	542	Cytoplasmic (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)				GTGATGAACTTCAAGGGCGAC	0.642									Paget_Disease_of_Bone				3	19					0	0	0	0	A	60052041	A	A	60052041	3	1	284	1	0	0	0	0	1	0	0	0	16350	1783	62	5	1663	5	TNFRSF11A	18	60052041	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08		60052041	18025207	186	52818											
C19orf29	58509	broad.mit.edu	37	chr19	3613204	3613204	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgtccaggctctgctggatCaggtcctcctccatgagcac	6	10	10	15	1	2	1	1	1	1	0	7	2	6	2	4	3	2	3	4	3	0	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:3613204C>G	uc002lyh.2	-	9	1691	c.1638G>C	c.(1636-1638)CTG>CTC	p.L546L	C19orf29_uc010xho.1_Silent_p.L5L|C19orf29_uc010dtn.2_Silent_p.L394L|C19orf29_uc002lyi.3_Silent_p.L546L|C19orf29_uc010dto.2_RNA|C19orf29_uc010xhp.1_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	546						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGCTGGATCAGGTCCTCCT	0.726													11	32					0	0	0	0	G	3613204	G	G	3613204	2	3	284	1	0	0	0	0	0	0	0	1	1927	813	29	2		2	C19orf29	19	3613204	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08		3613204	55515779	187	52819											
ADAMTS10	81794	broad.mit.edu	37	chr19	8657648	8657648	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggccctggccggcgctcaccCccttgtcgatggtgtgcgtc	2	9	14	16	4	1	0	1	0	0	0	3	1	1	0	4	4	1	1	4	4	0	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:8657648C>T	uc002mkj.1	-	13	1860	c.1586G>A	c.(1585-1587)GGG>GAG	p.G529E	ADAMTS10_uc002mki.1_5'Flank|ADAMTS10_uc002mkk.1_Missense_Mutation_p.G161E	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	529	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						GGCGCTCACCCCCTTGTCGAT	0.682													5	20					0	0	0	0	T	8657648	T	T	8657648	3	4	284	1	0	0	0	0	1	0	0	0	256	637	22	4	1781	4	ADAMTS10	19	8657648	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	5044444	8657648	50471335	188	52820											
OR7D2	162998	broad.mit.edu	37	chr19	9296835	9296835	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tatgaccggtttgtggctgtCtgccaccctctgcactatat	6	14	9	12	1	2	1	0	1	2	0	2	1	2	1	3	2	2	3	3	2	3	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:9296835C>G	uc002mkz.1	+	1	566	c.378C>G	c.(376-378)GTC>GTG	p.V126V		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	126	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						TTGTGGCTGTCTGCCACCCTC	0.512													43	152					0	0	0	0	G	9296835	G	G	9296835	2	3	284	1	0	0	0	0	0	0	0	1	11273	900	32	2		2	OR7D2	19	9296835	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	639187	9296835	49832148	189	52821											
DNM2	1785	broad.mit.edu	37	chr19	10883279	10883279	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcatctccccagtgcccatCaaccttcgagtctactcgcc	7	9	7	18	2	3	0	1	0	2	0	6	1	3	0	5	1	3	1	5	1	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:10883279C>G	uc002mps.1	+	3	524	c.360C>G	c.(358-360)ATC>ATG	p.I120M	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Missense_Mutation_p.I120M|DNM2_uc002mpv.1_Missense_Mutation_p.I120M|DNM2_uc002mpu.1_Missense_Mutation_p.I120M|DNM2_uc010dxl.1_Missense_Mutation_p.I120M	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	120					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CAGTGCCCATCAACCTTCGAG	0.552													11	40					0	0	0	0	G	10883279	G	G	10883279	3	3	284	1	0	0	0	0	1	0	0	0	4694	816	29	2	370	2	DNM2	19	10883279	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	1586444	10883279	48245704	190	52822											
FAM125A	93343	broad.mit.edu	37	chr19	17534558	17534558	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctctcgggcatccactcTgcggaggaatgactccatct	7	9	12	13	2	3	1	0	1	3	0	6	3	5	3	2	4	1	2	2	4	1	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:17534558T>A	uc002ngo.1	+	6	623	c.590T>A	c.(589-591)CTG>CAG	p.L197Q	FAM125A_uc002ngp.1_Missense_Mutation_p.L105Q|FAM125A_uc002ngq.1_Missense_Mutation_p.L93Q	NM_138401	NP_612410	Q96EY5	F125A_HUMAN	family with sequence similarity 125, member A	197	Interaction with TSG101, VPS37B and VPS28.				protein transport	late endosome membrane|microtubule organizing center|nucleus	SH3 domain binding				0						GCATCCACTCTGCGGAGGAAT	0.602													13	58					0	0	0	0	A	17534558	A	A	17534558	3	1	284	1	0	0	0	0	1	0	0	0	5455	1580	55	5	612	5	FAM125A	19	17534558	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	6651279	17534558	41594425	191	52823											
GDF15	9518	broad.mit.edu	37	chr19	18499466	18499466	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgctgccgtctgcacacggtCcgcgcgtcgctggaagacct	5	8	13	15	6	1	1	0	0	1	1	3	2	2	2	3	2	3	3	3	2	1	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:18499466C>T	uc002niv.2	+	2	680	c.648C>T	c.(646-648)GTC>GTT	p.V216V		NM_004864	NP_004855	Q99988	GDF15_HUMAN	growth differentiation factor 15	216					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)	1						TGCACACGGTCCGCGCGTCGC	0.731											OREG0025363	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	16					0	0	0	0	T	18499466	T	T	18499466	2	4	284	1	0	0	0	0	0	0	0	1	6350	842	30	2		2	GDF15	19	18499466	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	964908	18499466	40629517	192	52824											
CHST8	64377	broad.mit.edu	37	chr19	34263838	34263838	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccggcactcgcaggaggcgcGgaccacagcgaggatcgccc	8	2	15	16	6	0	0	0	0	0	0	2	4	0	3	3	5	1	2	3	5	0	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:34263838G>A	uc002nus.3	+	5	1650	c.1145G>A	c.(1144-1146)CGG>CAG	p.R382Q	CHST8_uc002nut.3_Missense_Mutation_p.R382Q|CHST8_uc002nuu.2_Missense_Mutation_p.R382Q	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	382	Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					CAGGAGGCGCGGACCACAGCG	0.612													5	30					0	0	0	0	A	34263838	A	A	34263838	3	1	284	1	0	0	0	0	1	0	0	0	3425	1116	39	1	1155	1	CHST8	19	34263838	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	15764372	34263838	24865145	193	52825											
RYR1	6261	broad.mit.edu	37	chr19	38997014	38997014	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttaccctgtcccgggagctGcaggtgagagccctgatcct	6	9	13	13	1	0	2	0	2	0	1	2	4	2	3	4	2	4	3	4	2	1	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:38997014G>T	uc002oit.2	+	55	8743	c.8613G>T	c.(8611-8613)CTG>CTT	p.L2871L	RYR1_uc002oiu.2_Silent_p.L2871L|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2871	6 X approximate repeats.|Cytoplasmic.|6.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCGGGAGCTGCAGGTGAGAG	0.592													7	30					0.00198382	0.0020289	1	0	T	38997014	T	T	38997014	2	4	284	1	0	0	0	0	0	0	0	1	13833	1306	46	4		4	RYR1	19	38997014	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	4733176	38997014	20131969	194	52826											
PAF1	54623	broad.mit.edu	37	chr19	39879407	39879407	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcaggaccacctacctaatCatggcctgagacatcatctc	12	8	7	14	0	3	1	2	1	1	1	4	3	3	2	4	2	2	1	4	2	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:39879407C>G	uc002old.2	-	9	910	c.735G>C	c.(733-735)ATG>ATC	p.M245I	PAF1_uc002ole.1_Missense_Mutation_p.M235I|PAF1_uc010xuv.1_RNA|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	245					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CCTACCTAATCATGGCCTGAG	0.547													14	34					0	0	0	0	G	39879407	G	G	39879407	3	3	284	1	0	0	0	0	1	0	0	0	11437	826	29	2	884	2	PAF1	19	39879407	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	882393	39879407	19249576	195	52827											
PAF1	54623	broad.mit.edu	37	chr19	39879807	39879807	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctttgtatatttcttcctCggtaaactgctgcttcacag	7	17	7	10	1	3	0	1	0	2	0	5	0	4	0	1	1	3	4	1	1	4	7			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:39879807C>A	uc002old.2	-	7	668	c.493G>T	c.(493-495)GAG>TAG	p.E165*	PAF1_uc002ole.1_Nonsense_Mutation_p.E155*|PAF1_uc010xuv.1_RNA|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	165					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			ATTTCTTCCTCGGTAAACTGC	0.473													27	85					4.22769e-11	4.51177e-11	1	0	A	39879807	A	A	39879807	4	1	284	1	0	0	0	0	0	1	0	0	11437	893	31	3	1134	3	PAF1	19	39879807	Nonsense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	400	39879807	19249176	196	52828											
AKT2	208	broad.mit.edu	37	chr19	40741810	40741810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccctcacctctgcttggggtCcttcttaagcagcccagcaa	7	10	8	16	0	3	0	1	0	2	0	4	0	4	0	4	2	4	3	4	2	2	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:40741810C>T	uc002onf.2	-	11	1424	c.1162G>A	c.(1162-1164)GAC>AAC	p.D388N	AKT2_uc010egs.2_Missense_Mutation_p.D345N|AKT2_uc010egt.2_Missense_Mutation_p.D326N|AKT2_uc010xvj.1_Missense_Mutation_p.D326N|AKT2_uc010egu.1_Missense_Mutation_p.D326N|AKT2_uc002one.2_Missense_Mutation_p.D284N	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	388	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)			TGCTTGGGGTCCTTCTTAAGC	0.682			A		ovarian|pancreatic 								3	22					0	0	0	0	T	40741810	T	T	40741810	3	4	284	1	0	0	0	0	1	0	0	0	480	855	30	2	299	2	AKT2	19	40741810	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	862003	40741810	18387173	197	52829											
PPP1R13L	10848	broad.mit.edu	37	chr19	45895566	45895566	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcccctctatctccggctCaggctccagctcggtggggg	4	8	13	16	2	3	0	1	0	2	0	6	0	4	0	4	5	2	3	4	5	1	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:45895566C>G	uc002pbn.2	-	8	1464	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q	PPP1R13L_uc002pbm.2_Missense_Mutation_p.E42Q|PPP1R13L_uc002pbo.2_Missense_Mutation_p.E463Q	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	463	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		ATCTCCGGCTCAGGCTCCAGC	0.642													6	35					0	0	0	0	G	45895566	G	G	45895566	3	3	284	1	0	0	0	0	1	0	0	0	12418	835	29	2	1123	2	PPP1R13L	19	45895566	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	5153756	45895566	13233417	198	52830											
SULT2A1	6822	broad.mit.edu	37	chr19	48389471	48389471	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttcggatctgaaacccataGtagggaaagctatgccttca	12	11	9	9	1	2	1	1	1	1	0	3	3	2	3	2	2	3	2	2	2	5	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:48389471G>A	uc002phr.2	-	1	184	c.44C>T	c.(43-45)ACT>ATT	p.T15I		NM_003167	NP_003158	Q06520	ST2A1_HUMAN	bile-salt sulfotransferase 2A1	15					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			ovary(1)|pancreas(1)	2		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		GAAACCCATAGTAGGGAAAGC	0.443													6	124					0	0	0	0	A	48389471	A	A	48389471	3	1	284	1	0	0	0	0	1	0	0	0	15447	1029	36	4	837	4	SULT2A1	19	48389471	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	2493905	48389471	10739512	199	52831											
FLT3LG	2323	broad.mit.edu	37	chr19	49979010	49979010	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gggacccaggactgctccttCcaacacagccccatctcctc	8	7	7	19	0	1	0	0	0	1	0	5	2	3	2	6	2	3	1	6	2	1	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:49979010C>G	uc010yau.1	+	3	186	c.96C>G	c.(94-96)TTC>TTG	p.F32L	FLT3LG_uc002pnv.2_5'UTR|FLT3LG_uc002pnw.2_5'UTR|FLT3LG_uc002pnu.2_Missense_Mutation_p.F32L|FLT3LG_uc002pnx.2_Missense_Mutation_p.F32L|FLT3LG_uc010yav.1_5'UTR	NM_001459	NP_001450	P49771	FLT3L_HUMAN	fms-related tyrosine kinase 3 ligand precursor	32	Extracellular (Potential).				positive regulation of cell proliferation|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity				0		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		ACTGCTCCTTCCAACACAGCC	0.642													13	41					0	0	0	0	G	49979010	G	G	49979010	3	3	284	1	0	0	0	0	1	0	0	0	5975	854	30	2	102	2	FLT3LG	19	49979010	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	1589539	49979010	9149973	200	52832											
ZNF610	162963	broad.mit.edu	37	chr19	52869339	52869339	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaccttacaaatgtactgaAtgtggcaaggtcttcagtcg	13	11	9	8	1	2	1	1	1	1	0	3	1	2	1	1	2	3	2	1	2	6	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:52869339A>G	uc002pyx.3	+	6	1114	c.708A>G	c.(706-708)GAA>GAG	p.E236E	ZNF610_uc002pyy.3_Silent_p.E236E|ZNF610_uc002pyz.3_Silent_p.E193E|ZNF610_uc002pza.2_Silent_p.E236E	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	236	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		AATGTACTGAATGTGGCAAGG	0.388													10	31					0	0	0	0	G	52869339	G	G	52869339	2	3	284	1	0	0	0	0	0	0	0	1	18103	98	4	5		5	ZNF610	19	52869339	Silent	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	2890329	52869339	6259644	201	52833											
ZNF321	399669	broad.mit.edu	37	chr19	53432295	53432295	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tttgggatgtcaaaattaagGaggcattgatgatagacttc	13	13	11	4	0	1	3	1	2	0	1	2	5	1	5	0	3	0	1	0	3	4	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:53432295G>C	uc010eqj.2	-	4	685	c.515C>G	c.(514-516)TCC>TGC	p.S172C	ZNF321_uc002qaj.1_Missense_Mutation_p.S119C|ZNF321_uc002qak.1_Missense_Mutation_p.S172C	NM_203307	NP_976052			zinc finger protein 321												0				GBM - Glioblastoma multiforme(134;0.0305)		CAAAATTAAGGAGGCATTGAT	0.378													25	105					0	0	0	0	C	53432295	C	C	53432295	3	2	284	1	0	0	0	0	1	0	0	0	17907	1174	41	2	142	2	ZNF321	19	53432295	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	562956	53432295	5696688	202	52834											
NLRP8	126205	broad.mit.edu	37	chr19	56466905	56466905	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccttggcatgagtattcttcGgagaattgcaggtgaggaag	10	11	14	6	1	1	3	0	2	1	1	2	5	1	4	1	4	1	3	1	4	3	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:56466905G>A	uc002qmh.2	+	3	1552	c.1481G>A	c.(1480-1482)CGG>CAG	p.R494Q	NLRP8_uc010etg.2_Missense_Mutation_p.R494Q	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	494	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AGTATTCTTCGGAGAATTGCA	0.468													30	107					0	0	0	0	A	56466905	A	A	56466905	3	1	284	1	0	0	0	0	1	0	0	0	10537	1116	39	1	1491	1	NLRP8	19	56466905	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	3034610	56466905	2662078	203	52835											
ZNF550	162972	broad.mit.edu	37	chr19	58067717	58067717	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagccacatccttgaaggtCaccaacatctggaaagtcaa	15	7	7	12	0	3	1	2	1	1	0	4	2	4	2	3	2	2	0	3	2	4	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr19:58067717C>T	uc002qpe.1	-	1	9	c.9G>A	c.(7-9)GTG>GTA	p.V3V	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_3'UTR|ZNF550_uc002qpc.2_RNA|ZNF550_uc010eue.1_RNA|ZNF550_uc002qpd.2_RNA	NM_001039654	NP_001034743	Q7Z398	ZN550_HUMAN	zinc finger protein 550	12	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCTTGAAGGTCACCAACATCT	0.522													22	108					0	0	0	0	T	58067717	T	T	58067717	2	4	284	1	0	0	0	0	0	0	0	1	18049	813	29	2		2	ZNF550	19	58067717	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	1600812	58067717	1061266	204	52836											
ZNF343	79175	broad.mit.edu	37	chr20	2464844	2464844	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctcgggtttgtaataaagtTtgattccaggttatggtccg	8	15	11	7	2	0	1	0	1	0	0	3	1	2	1	3	3	0	4	3	3	4	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr20:2464844T>C	uc002wge.1	-	6	1251	c.763A>G	c.(763-765)AAC>GAC	p.N255D	ZNF343_uc010gao.1_Missense_Mutation_p.N255D|ZNF343_uc002wgd.1_Missense_Mutation_p.N165D	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GTAATAAAGTTTGATTCCAGG	0.438													7	90					0	0	0	0	C	2464844	C	C	2464844	3	2	284	1	0	0	0	0	1	0	0	0	17925	1841	64	5	1040	5	ZNF343	20	2464844	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08		2464844	60560676	205	52837											
ITSN1	6453	broad.mit.edu	37	chr21	35190747	35190747	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccaagtcttacgtgaaactCatttcagggcccataaggaa	13	9	8	11	1	3	1	2	1	1	0	3	2	3	2	2	2	2	0	2	2	5	3			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr21:35190747C>G	uc002yta.1	+	23	3172	c.2904C>G	c.(2902-2904)CTC>CTG	p.L968L	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Silent_p.L963L|ITSN1_uc010gmg.2_Silent_p.L926L|ITSN1_uc010gmh.2_Intron|ITSN1_uc002ysw.2_Silent_p.L968L|ITSN1_uc010gmi.2_Silent_p.L931L|ITSN1_uc010gmj.2_Silent_p.L847L|ITSN1_uc002ysy.2_Silent_p.L963L|ITSN1_uc002ysx.2_Silent_p.L926L|ITSN1_uc002ytb.1_Silent_p.L963L|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Silent_p.L931L|ITSN1_uc010gml.2_Intron|ITSN1_uc002ytj.2_Silent_p.L963L|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Silent_p.L902L|ITSN1_uc002ytg.1_Silent_p.L21L	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	968	SH3 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						ACGTGAAACTCATTTCAGGGC	0.393													57	79					0	0	0	0	G	35190747	G	G	35190747	2	3	284	1	0	0	0	0	0	0	0	1	7965	813	29	2		2	ITSN1	21	35190747	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08		35190747	12939148	206	52838											
RGL4	266747	broad.mit.edu	37	chr22	24035973	24035973	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaagaaggtggtgctccacGaatgcttgggctgcatctgg	8	10	14	9	1	2	1	1	0	1	1	3	2	3	1	1	4	3	4	1	4	3	1	rs145276888		TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr22:24035973G>A	uc002zxn.2	+	4	1894	c.724G>A	c.(724-726)GAA>AAA	p.E242K	LOC91316_uc002zxh.3_5'Flank|LOC91316_uc002zxi.3_5'Flank|LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Missense_Mutation_p.E242K|RGL4_uc002zxp.1_Missense_Mutation_p.E106K|RGL4_uc002zxq.2_Missense_Mutation_p.E106K	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	242	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						GGTGCTCCACGAATGCTTGGG	0.582													10	47					0	0	0	0	A	24035973	A	A	24035973	3	1	284	1	0	0	0	0	1	0	0	0	13344	1059	37	1	738	1	RGL4	22	24035973	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		24035973	27268593	207	52839											
MYO18B	84700	broad.mit.edu	37	chr22	26343789	26343789	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agaagcacaaggacctcattGctcaggtagtgaatgagacc	14	7	11	9	0	2	3	2	2	0	2	2	5	2	4	2	2	2	3	2	2	4	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr22:26343789G>C	uc003abz.1	+	36	5993	c.5743G>C	c.(5743-5745)GCT>CCT	p.A1915P	MYO18B_uc003aca.1_Missense_Mutation_p.A1796P|MYO18B_uc010guy.1_Missense_Mutation_p.A1797P|MYO18B_uc010guz.1_Missense_Mutation_p.A1795P|MYO18B_uc011aka.1_Missense_Mutation_p.A1069P|MYO18B_uc011akb.1_Missense_Mutation_p.A1428P	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1915	Tail.|Potential.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGACCTCATTGCTCAGGTAGT	0.537													7	19					0	0	0	0	C	26343789	C	C	26343789	3	2	284	1	0	0	0	0	1	0	0	0	10119	1319	46	4	5881	4	MYO18B	22	26343789	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	2307816	26343789	24960777	208	52840											
TRIOBP	11078	broad.mit.edu	37	chr22	38131322	38131322	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gctgcccagccctgcctgcaCctccacccagtggccaaaga	8	5	9	19	0	0	1	0	0	0	1	1	1	1	1	7	1	4	2	7	1	1	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr22:38131322C>G	uc003atr.2	+	9	5250	c.4979C>G	c.(4978-4980)ACC>AGC	p.T1660S	TRIOBP_uc003atu.2_Missense_Mutation_p.T1488S	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	1660					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCTGCCTGCACCTCCACCCAG	0.677											OREG0026548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	28					0	0	0	0	G	38131322	G	G	38131322	3	3	284	1	0	0	0	0	1	0	0	0	16620	507	18	4	5005	4	TRIOBP	22	38131322	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	11787533	38131322	13173244	209	52841											
CELSR1	9620	broad.mit.edu	37	chr22	46785346	46785346	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgcagcgccctcaccagctgCagggccctggcgccgtccac	5	4	12	20	4	1	0	1	0	0	0	2	0	2	0	5	2	3	3	5	2	0	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr22:46785346C>T	uc003bhw.1	-	18	6396	c.6396G>A	c.(6394-6396)CTG>CTA	p.L2132L	CELSR1_uc011arc.1_Silent_p.L453L	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2132	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCACCAGCTGCAGGGCCCTGG	0.637													9	36					0	0	0	0	T	46785346	T	T	46785346	2	4	284	1	0	0	0	0	0	0	0	1	3236	697	25	4		4	CELSR1	22	46785346	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	8654024	46785346	4519220	210	52842											
MAPK11	5600	broad.mit.edu	37	chr22	50703900	50703900	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggtcactgtccagcaccaGcatccttccaaggaggtcta	9	9	9	14	0	2	0	1	0	1	0	5	1	5	1	4	3	2	2	4	3	2	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr22:50703900G>A	uc003bkr.2	-	11	923	c.865C>T	c.(865-867)CTG>TTG	p.L289L	MAPK11_uc010hax.2_Silent_p.L111L|MAPK11_uc011ars.1_RNA|MAPK11_uc010hay.1_RNA	NM_002751	NP_002742	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	289	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			lung(1)|breast(1)	2		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCCAGCACCAGCATCCTTCCA	0.637													4	52					0	0	0	0	A	50703900	A	A	50703900	2	1	284	1	0	0	0	0	0	0	0	1	9326	962	34	4		4	MAPK11	22	50703900	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	3918554	50703900	600666	211	52843											
SBF1	6305	broad.mit.edu	37	chr22	50886980	50886980	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccctcactcacacggccgtCtggccggccctcgaggcgct	4	6	12	19	5	3	0	2	0	1	0	4	1	3	0	4	4	0	1	4	4	0	0			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chr22:50886980C>G	uc003blh.2	-	37	5338	c.5143G>C	c.(5143-5145)GAC>CAC	p.D1715H	SBF1_uc003ble.2_Missense_Mutation_p.D179H|SBF1_uc003blf.2_Missense_Mutation_p.D191H|SBF1_uc011arx.1_Missense_Mutation_p.D1353H	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1689					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		ACACGGCCGTCTGGCCGGCCC	0.657													4	31					0	0	0	0	G	50886980	G	G	50886980	3	3	284	1	0	0	0	0	1	0	0	0	13923	913	32	2	558	2	SBF1	22	50886980	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	183080	50886980	417586	212	52844											
SHROOM2	357	broad.mit.edu	37	chrX	9862972	9862972	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccagggccctgtgttctcaGaggcggctgcggcacagcac	6	6	14	15	2	1	1	1	0	1	1	2	1	1	1	2	4	2	4	2	4	0	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:9862972G>C	uc004csu.1	+	4	1114	c.1024G>C	c.(1024-1026)GAG>CAG	p.E342Q		NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	342					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				TGTGTTCTCAGAGGCGGCTGC	0.657													6	28					0	0	0	0	C	9862972	C	C	9862972	3	2	284	1	0	0	0	0	1	0	0	0	14359	943	33	2	1038	2	SHROOM2	23	9862972	Missense_Mutation	SNP	G	TCGA-DQ-5625-01A-01D-1870-08		9862972	145407588	213	52845											
MAP3K15	389840	broad.mit.edu	37	chrX	19398256	19398256	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actttgaacatggctgcctgCggctcaccaagctcatggaa	10	9	10	12	1	2	1	2	1	0	0	2	2	2	2	2	3	4	3	2	3	3	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:19398256C>T	uc004czk.1	-	20	2633	c.996G>A	c.(994-996)CCG>CCA	p.P332P	MAP3K15_uc004czj.1_Silent_p.P292P	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	857	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					TGGCTGCCTGCGGCTCACCAA	0.448													5	11					0	0	0	0	T	19398256	T	T	19398256	2	4	284	1	0	0	0	0	0	0	0	1	9302	755	27	1		1	MAP3K15	23	19398256	Silent	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	9535284	19398256	135872304	214	52846											
MAGEB1	4112	broad.mit.edu	37	chrX	30269432	30269432	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tatcaattcctatggggtccGagagcctatgctgaaaccac	11	10	9	11	1	1	2	1	1	0	1	3	3	3	2	4	2	3	1	4	2	5	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:30269432G>A	uc004dcc.2	+	4	1142	c.822G>A	c.(820-822)CCG>CCA	p.P274P	MAGEB1_uc004dcd.2_Silent_p.P274P|MAGEB1_uc004dce.2_Silent_p.P274P	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	274	MAGE.										0						TATGGGGTCCGAGAGCCTATG	0.502													19	90					0	0	0	0	A	30269432	A	A	30269432	2	1	284	1	0	0	0	0	0	0	0	1	9225	1045	37	1		1	MAGEB1	23	30269432	Silent	SNP	G	TCGA-DQ-5625-01A-01D-1870-08	10871176	30269432	125001128	215	52847											
DMD	1756	broad.mit.edu	37	chrX	31950313	31950313	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcatttaaatctctttgaaAttctgacaagatattctttt	12	20	3	6	0	4	3	1	2	3	1	5	3	4	3	0	0	0	0	0	0	5	9			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:31950313A>G	uc004dda.1	-	46	6890	c.6646T>C	c.(6646-6648)TTT>CTT	p.F2216L	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.F872L|DMD_uc004dcx.2_Missense_Mutation_p.F875L|DMD_uc004dcz.2_Missense_Mutation_p.F2093L|DMD_uc004dcy.1_Missense_Mutation_p.F2212L|DMD_uc004ddb.1_Missense_Mutation_p.F2208L|DMD_uc010ngo.1_Missense_Mutation_p.F125L|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2216	Spectrin 16.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTCTTTGAAATTCTGACAAG	0.303													10	36					0	0	0	0	G	31950313	G	G	31950313	3	3	284	1	0	0	0	0	1	0	0	0	4602	101	4	5	4695	5	DMD	23	31950313	Missense_Mutation	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	1680881	31950313	123320247	216	52848											
RPGR	6103	broad.mit.edu	37	chrX	38135929	38135929	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtaggaacactttcatcatCtcccacagttttcttcttgc	8	16	5	12	0	5	0	2	0	3	0	6	1	5	1	1	1	2	2	1	1	2	6			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:38135929C>T	uc004deb.2	-	16	2170	c.2002G>A	c.(2002-2004)GAT>AAT	p.D668N	RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA	NM_000328	NP_000319	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform A	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						CTTTCATCATCTCCCACAGTT	0.358													20	107					0	0	0	0	T	38135929	T	T	38135929	3	4	284	1	0	0	0	0	1	0	0	0	13613	913	32	2	461	2	RPGR	23	38135929	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	6185616	38135929	117134631	217	52849											
USP9X	8239	broad.mit.edu	37	chrX	40988323	40988323	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgagcaaggtcaaggtgatgCcccaccacagcttgaagatg	12	7	12	10	0	1	4	1	3	0	1	1	4	1	4	3	2	3	2	3	2	3	1			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:40988323C>T	uc004dfb.2	+	3	800	c.167C>T	c.(166-168)GCC>GTC	p.A56V	USP9X_uc004dfc.2_Missense_Mutation_p.A56V	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	56					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						CAAGGTGATGCCCCACCACAG	0.443													3	43					0	0	0	0	T	40988323	T	T	40988323	3	4	284	1	0	0	0	0	1	0	0	0	17158	739	26	4	173	4	USP9X	23	40988323	Missense_Mutation	SNP	C	TCGA-DQ-5625-01A-01D-1870-08	2852394	40988323	114282237	218	52850											
PORCN	64840	broad.mit.edu	37	chrX	48370791	48370791	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgaggtgggtacggtgcccTcgccagtggagttcatgggc	5	8	18	10	3	1	0	1	0	0	0	2	2	1	1	2	5	2	2	2	5	1	2			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:48370791T>A	uc010nie.1	+	5	609	c.451T>A	c.(451-453)TCG>ACG	p.S151T	PORCN_uc004djr.1_Missense_Mutation_p.S151T|PORCN_uc004djs.1_Missense_Mutation_p.S151T|PORCN_uc004djt.1_Missense_Mutation_p.S80T|PORCN_uc011mlx.1_Missense_Mutation_p.S80T|PORCN_uc004dju.1_Missense_Mutation_p.S20T|PORCN_uc004djv.1_Missense_Mutation_p.S151T|PORCN_uc004djw.1_Missense_Mutation_p.S151T	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	151	Extracellular (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						TACGGTGCCCTCGCCAGTGGA	0.607													4	34					0	0	0	0	A	48370791	A	A	48370791	3	1	284	1	0	0	0	0	1	0	0	0	12313	1551	54	5	465	5	PORCN	23	48370791	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	7382468	48370791	106899769	219	52851											
DGKK	139189	broad.mit.edu	37	chrX	50213559	50213570	+	In_Frame_Del	DEL	GGCGGAGCCGGT	-	-																															agagcagcggcggagccggcGgcggagccggtggtggtggc																										TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:50213559_50213570delGGCGGAGCCGGT	uc010njr.1	-	1	168_179	c.108_119delACCGGCTCCGCC	c.(106-120)CCACCGGCTCCGCCG>CCG	p.36_40PPAPP>P		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	36_40					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					cggagccggcggcggagccggtggtggtggcg	0.462													---	---	---								-	50213570	-	-	50213559	7	5	284	1	0	1	0	1	0	0	0	0	4494	1116	39	0	3807	0	DGKK	23	50213559	In_Frame_Del	DEL	GGCGGAGCCGGT	TCGA-DQ-5625-01A-01D-1870-08	1842768	50213559	105057001	220	52852											
HUWE1	10075	broad.mit.edu	37	chrX	53563587	53563589	+	In_Frame_Del	DEL	CCA	-	-																															tataccactcccgcaggagcCcaccagcatcctgcccttct																								rs426298	byFrequency	TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:53563587_53563589delCCA	uc004dsp.2	-	79	12579_12581	c.12177_12179delTGG	c.(12175-12180)GGTGGG>GGG	p.4059_4060GG>G	HUWE1_uc004dsn.2_In_Frame_Del_p.2867_2868GG>G	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4059_4060	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CCGCAGGAGCCCACCAGCATCCT	0.473													---	---	---								-	53563589	-	-	53563587	7	5	284	1	0	1	0	1	0	0	0	0	7500	623	22	0	969	0	HUWE1	23	53563587	In_Frame_Del	DEL	CCA	TCGA-DQ-5625-01A-01D-1870-08	3350028	53563587	101706973	221	52853											
ATRX	546	broad.mit.edu	37	chrX	76944323	76944323	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacataccttacaaataagAacttgcaatgaagggtgtct	15	12	7	7	0	1	2	0	1	1	1	1	2	1	2	1	1	5	1	1	1	8	5			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:76944323A>T	uc004ecp.3	-	7	814	c.582T>A	c.(580-582)GTT>GTA	p.V194V	ATRX_uc004ecq.3_Silent_p.V156V|ATRX_uc004eco.3_5'UTR|ATRX_uc004ecr.2_Silent_p.V155V|ATRX_uc010nlx.1_Silent_p.V194V|ATRX_uc010nly.1_Silent_p.V139V	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	194	ADD.|GATA-type; atypical.		V -> I (in ATRX).|Missing (in ATRX).		DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TACAAATAAGAACTTGCAATG	0.249			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						48	94					0	0	0	0	T	76944323	T	T	76944323	2	4	284	1	0	0	0	0	0	0	0	1	1210	233	9	5		5	ATRX	23	76944323	Silent	SNP	A	TCGA-DQ-5625-01A-01D-1870-08	23380736	76944323	78326237	222	52854											
BHLHB9	80823	broad.mit.edu	37	chrX	102005206	102005206	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acagcaatctggattaaagaTactaggacaactgactactg	16	9	8	8	0	1	2	0	1	1	1	1	4	1	4	0	2	4	1	0	2	7	4			TCGA-DQ-5625-01A-01D-1870-08	TCGA-DQ-5625-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	4e042e1d-8604-484a-b229-94b85745a478	eca3d25f-f215-420e-b040-ade10a9cee53	g.chrX:102005206T>A	uc010nog.2	+	4	1854	c.1283T>A	c.(1282-1284)ATA>AAA	p.I428K	BHLHB9_uc011mrq.1_Missense_Mutation_p.I428K|BHLHB9_uc011mrr.1_Missense_Mutation_p.I428K|BHLHB9_uc011mrs.1_Missense_Mutation_p.I428K|BHLHB9_uc011mrt.1_Missense_Mutation_p.I428K|BHLHB9_uc004ejo.2_Missense_Mutation_p.I428K|BHLHB9_uc011mru.1_Missense_Mutation_p.I428K|BHLHB9_uc011mrv.1_Missense_Mutation_p.I428K	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	428						cytoplasm|nucleus	binding			ovary(2)	2						GGATTAAAGATACTAGGACAA	0.373													49	47					0	0	0	0	A	102005206	A	A	102005206	3	1	284	1	0	0	0	0	1	0	0	0	1423	1406	49	5	1285	5	BHLHB9	23	102005206	Missense_Mutation	SNP	T	TCGA-DQ-5625-01A-01D-1870-08	25060883	102005206	53265354	223	52855											
AGRN	375790	broad.mit.edu	37	chr1	957724	957724	+	Frame_Shift_Del	DEL	C	-	-																															actggggacaccaggatcttCtttgtgaaccctgcaccccc																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:957724delC	uc001ack.1	+	2	395	c.345delC	c.(343-345)TTCfs	p.F115fs		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	115	NtA.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CCAGGATCTTCTTTGTGAACC	0.607													---	---	---								-	957724	-	-	957724	7	5	285	1	0	1	0	1	0	0	0	0	397	912	32	0	351	0	AGRN	1	957724	Frame_Shift_Del	DEL	C	TCGA-DQ-5629-01A-01D-1870-08		957724	248292897	1	52856											
SKI	6497	broad.mit.edu	37	chr1	2160628	2160628	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgctgcagcagatcaacgcGgtgtgcgacgagctccacat	9	7	12	13	5	1	1	1	0	0	1	3	3	2	1	1	1	5	4	1	1	1	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:2160628G>C	uc001aja.3	+	1	495	c.423G>C	c.(421-423)GCG>GCC	p.A141A		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	141					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		AGATCAACGCGGTGTGCGACG	0.632													12	3					0	0	0	0	C	2160628	C	C	2160628	2	2	285	1	0	0	0	0	0	0	0	1	14422	1103	39	3		3	SKI	1	2160628	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1202904	2160628	247089993	2	52857											
PIK3CD	5293	broad.mit.edu	37	chr1	9775652	9775652	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccacatgctcagtggcccCgaggcctatgtgttcacctg	6	11	10	14	1	2	0	2	0	0	0	3	1	3	0	5	2	1	2	5	2	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:9775652C>T	uc001aqb.3	+	4	403	c.195C>T	c.(193-195)CCC>CCT	p.P65P	PIK3CD_uc001aqa.2_Silent_p.P65P|PIK3CD_uc010oaf.1_Silent_p.P65P|PIK3CD_uc001aqe.3_Silent_p.P65P	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	65					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		TCAGTGGCCCCGAGGCCTATG	0.647													10	21					0	0	0	0	T	9775652	T	T	9775652	2	4	285	1	0	0	0	0	0	0	0	1	11970	639	23	1		1	PIK3CD	1	9775652	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	7615024	9775652	239474969	3	52858											
PIK3CD	5293	broad.mit.edu	37	chr1	9776604	9776604	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccgctggtggagcagcCggaagactacacgctgcagg	9	4	16	12	3	0	1	0	0	0	1	0	3	0	3	2	4	5	5	2	4	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:9776604C>T	uc001aqb.3	+	6	915	c.707C>T	c.(706-708)CCG>CTG	p.P236L	PIK3CD_uc010oaf.1_Missense_Mutation_p.P236L|PIK3CD_uc001aqe.3_Missense_Mutation_p.P236L	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	236					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GTGGAGCAGCCGGAAGACTAC	0.642													3	4					0	0	0	0	T	9776604	T	T	9776604	3	4	285	1	0	0	0	0	1	0	0	0	11970	652	23	1	721	1	PIK3CD	1	9776604	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	952	9776604	239474017	4	52859											
PLOD1	5351	broad.mit.edu	37	chr1	12016977	12016977	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctttctgacccccagatgAggtcgtgctcaagtttgaaa	9	12	10	10	1	2	4	1	3	1	1	3	4	2	4	2	1	2	3	2	1	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:12016977A>T	uc001atm.2	+	7	738	c.647A>T	c.(646-648)GAG>GTG	p.E216V	PLOD1_uc010obb.1_Missense_Mutation_p.E263V	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	216					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	CCCCCAGATGAGGTCGTGCTC	0.423													17	13					0	0	0	0	T	12016977	T	T	12016977	3	4	285	1	0	0	0	0	1	0	0	0	12156	304	11	5	673	5	PLOD1	1	12016977	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	2240373	12016977	237233644	5	52860											
NBPF1	55672	broad.mit.edu	37	chr1	16901659	16901659	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tattcagtgttacctgggggCagacgatttctgcactttct	7	15	10	9	1	3	1	1	0	2	1	3	2	3	1	1	2	2	3	1	2	2	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:16901659C>A	uc009vos.1	-	20	3073	c.2185G>T	c.(2185-2187)GCC>TCC	p.A729S	NBPF1_uc009vot.1_Missense_Mutation_p.A187S|NBPF1_uc001ayz.1_Missense_Mutation_p.A187S|NBPF1_uc010oce.1_Missense_Mutation_p.A458S	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	729	NBPF 3.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TACCTGGGGGCAGACGATTTC	0.423													8	200					9.70103e-10	1.11327e-09	1	0	A	16901659	A	A	16901659	3	1	285	1	0	0	0	0	1	0	0	0	10245	710	25	4	1279	4	NBPF1	1	16901659	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	4884682	16901659	232348962	6	52861											
C1orf94	84970	broad.mit.edu	37	chr1	34667770	34667770	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactttcctacagccatgacCtcagcaaccctgaaccagcc	11	7	5	18	0	1	2	1	2	0	0	2	2	2	2	6	0	6	1	6	0	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:34667770C>T	uc001bxs.3	+	4	1185	c.786C>T	c.(784-786)ACC>ACT	p.T262T	C1orf94_uc001bxt.2_Silent_p.T452T	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	262							protein binding				0		Myeloproliferative disorder(586;0.0393)				CAGCCATGACCTCAGCAACCC	0.507													38	11					0	0	0	0	T	34667770	T	T	34667770	2	4	285	1	0	0	0	0	0	0	0	1	2081	668	24	4		4	C1orf94	1	34667770	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	17766111	34667770	214582851	7	52862											
KTI12	112970	broad.mit.edu	37	chr1	52499425	52499425	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcagcccgcaaaacaccacGagcggcatcctctcagggag	11	3	12	15	3	1	0	1	0	1	0	3	2	2	1	3	3	3	3	3	3	2	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:52499425G>A	uc001ctj.1	-	1	48	c.9C>T	c.(7-9)CTC>CTT	p.L3L	TXNDC12_uc001cti.2_Intron	NM_138417	NP_612426	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated	3							ATP binding			central_nervous_system(2)	2						AAAACACCACGAGCGGCATCC	0.662													8	3					0	0	0	0	A	52499425	A	A	52499425	2	1	285	1	0	0	0	0	0	0	0	1	8624	1045	37	1		1	KTI12	1	52499425	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	17831655	52499425	196751196	8	52863											
ELTD1	64123	broad.mit.edu	37	chr1	79403504	79403504	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcttacctatatccgttgAatttgtatcaaactctgtgg	9	18	6	8	1	3	1	1	1	2	0	4	1	4	1	2	1	2	2	2	1	6	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:79403504A>T	uc001diq.3	-	6	904	c.748T>A	c.(748-750)TCA>ACA	p.S250T		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	250	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		ATATCCGTTGAATTTGTATCA	0.378													61	51					0	0	0	0	T	79403504	T	T	79403504	3	4	285	1	0	0	0	0	1	0	0	0	5108	246	9	5	1364	5	ELTD1	1	79403504	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	26904079	79403504	169847117	9	52864											
RTCD1	8634	broad.mit.edu	37	chr1	100752670	100752670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatagctgattgttttcatgGcattagccaatggagtttcc	10	15	9	7	0	1	1	1	1	0	0	2	2	2	2	2	2	2	4	2	2	4	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:100752670G>A	uc001dtc.2	+	10	1128	c.910G>A	c.(910-912)GCA>ACA	p.A304T	RTCD1_uc001dtd.2_Missense_Mutation_p.A317T	NM_003729	NP_003720	O00442	RTC1_HUMAN	RNA terminal phosphate cyclase domain 1 isoform	304					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0513)|all cancers(265;0.0902)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)		TGTTTTCATGGCATTAGCCAA	0.338													3	42					0	0	0	0	A	100752670	A	A	100752670	3	1	285	1	0	0	0	0	1	0	0	0	13783	1203	42	4	991	4	RTCD1	1	100752670	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	21349166	100752670	148497951	10	52865											
COL11A1	1301	broad.mit.edu	37	chr1	103449722	103449723	+	Missense_Mutation	DNP	GG	TT	TT																															cttgtcttcctggatatcctGgtaatcctggaactccaagt																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:103449722_103449723GG>TT	uc001dul.2	-	31	2845_2846	c.2527_2528CC>AA	c.(2527-2529)CCA>AAA	p.P843K	COL11A1_uc001duk.2_Nonsense_Mutation_p.33_34YQ>*K|COL11A1_uc001dum.2_Missense_Mutation_p.P855K|COL11A1_uc001dun.2_Missense_Mutation_p.P804K|COL11A1_uc009weh.2_Missense_Mutation_p.P727K	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	843	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGGATATCCTGGTAATCCTGGA	0.223													7	9					0	0	0	0	TT	103449723	TT	TT	103449722	3	4	285	1	0	0	0	0	1	0	0	0	3682	1348	47	4	3040	4	COL11A1	1	103449722	Missense_Mutation	DNP	GG	TCGA-DQ-5629-01A-01D-1870-08	2697052	103449722	145800899	11	52866											
NOTCH2NL	388677	broad.mit.edu	37	chr1	145273384	145273384	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgaccttgcctgaatggcGgcacatgccatatgctcagc	8	9	10	14	2	1	1	1	1	0	0	2	2	1	1	3	2	4	2	3	2	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:145273384G>T	uc001emn.3	+	3	608	c.238G>T	c.(238-240)GGC>TGC	p.G80C	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Missense_Mutation_p.G80C|NOTCH2NL_uc001emo.2_Missense_Mutation_p.G80C|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	80	EGF-like 3.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						CCTGAATGGCGGCACATGCCA	0.532													48	525					5.57489e-27	7.66548e-27	1	0	T	145273384	T	T	145273384	3	4	285	1	0	0	0	0	1	0	0	0	10603	1116	39	3	244	3	NOTCH2NL	1	145273384	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	41823662	145273384	103977237	12	52867											
SNX27	81609	broad.mit.edu	37	chr1	151641106	151641106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgctgttacctacttctttCatcaggtaggtgaattgatc	8	17	8	8	0	3	2	2	2	1	0	4	2	3	2	1	2	3	3	1	2	4	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:151641106C>T	uc001eyn.1	+	7	1160	c.1144C>T	c.(1144-1146)CAT>TAT	p.H382Y	SNX27_uc001eyo.2_Missense_Mutation_p.H289Y|SNX27_uc001eyp.2_Missense_Mutation_p.H196Y	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	382					cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTACTTCTTTCATCAGGTAGG	0.308													19	45					0	0	0	0	T	151641106	T	T	151641106	3	4	285	1	0	0	0	0	1	0	0	0	14961	826	29	2	1170	2	SNX27	1	151641106	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	6367722	151641106	97609515	13	52868											
S100A7A	338324	broad.mit.edu	37	chr1	153390678	153390678	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	acgatgatgaaggagaacttCcccaatttcctcagtgcctg	11	10	9	11	1	1	3	1	2	0	1	3	5	3	3	4	1	2	0	4	1	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:153390678C>T	uc001fbt.1	+	2	177	c.120C>T	c.(118-120)TTC>TTT	p.F40F		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	40	EF-hand 1.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGGAGAACTTCCCCAATTTCC	0.438													63	76					0	0	0	0	T	153390678	T	T	153390678	2	4	285	1	0	0	0	0	0	0	0	1	13849	854	30	2		2	S100A7A	1	153390678	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1749572	153390678	95859943	14	52869											
CD1E	913	broad.mit.edu	37	chr1	158326571	158326571	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cagccctgtctttctcatggGagccaacactcaggacacca	10	8	8	15	0	3	0	2	0	2	0	4	2	3	2	3	2	3	0	3	2	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:158326571G>A	uc001fse.2	+	6	1291	c.1052G>A	c.(1051-1053)GGA>GAA	p.G351E	CD1E_uc001fsd.2_3'UTR|CD1E_uc001fsk.2_Missense_Mutation_p.G261E|CD1E_uc001fsj.2_Missense_Mutation_p.G194E|CD1E_uc001fsc.2_Missense_Mutation_p.G162E|CD1E_uc010pig.1_RNA|CD1E_uc001fsa.2_Missense_Mutation_p.G107E|CD1E_uc001fsf.2_Missense_Mutation_p.G339E|CD1E_uc001fry.2_Missense_Mutation_p.G284E|CD1E_uc001fsg.2_3'UTR|CD1E_uc001fsh.2_Missense_Mutation_p.G150E|CD1E_uc001fsi.2_3'UTR|CD1E_uc009wsv.2_Missense_Mutation_p.G252E|CD1E_uc001frz.2_Missense_Mutation_p.G249E|CD1E_uc009wsw.2_Missense_Mutation_p.E66K	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	351					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					TTTCTCATGGGAGCCAACACT	0.403													45	58					0	0	0	0	A	158326571	A	A	158326571	3	1	285	1	0	0	0	0	1	0	0	0	2993	1174	41	2	1074	2	CD1E	1	158326571	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4935893	158326571	90924050	15	52870											
SPTA1	6708	broad.mit.edu	37	chr1	158641244	158641244	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcgttttccaggaaggcCtgtagaagacagaaagacac	13	8	10	10	1	0	4	0	0	0	4	3	5	2	5	3	2	0	2	3	2	4	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:158641244C>A	uc001fst.1	-	12	1688	c.1489_splice	c.e12-1	p.A497_splice		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCAGGAAGGCCTGTAGAAGAC	0.498													15	36					3.41278e-10	3.96692e-10	1	0	A	158641244	A	A	158641244	5	1	285	1	0	0	0	0	0	0	1	0	15182	695	24	4	5935	4	SPTA1	1	158641244	Splice_Site	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	314673	158641244	90609377	16	52871											
OR6K2	81448	broad.mit.edu	37	chr1	158669573	158669573	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttattcctcaggctataGataatggggttgaagaaggg	11	13	12	5	0	2	3	1	1	1	2	3	3	3	3	1	4	0	2	1	4	6	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:158669573G>T	uc001fsu.1	-	1	870	c.870C>A	c.(868-870)ATC>ATA	p.I290I		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TCAGGCTATAGATAATGGGGT	0.403													19	27					6.94344e-10	8.02947e-10	1	0	T	158669573	T	T	158669573	2	4	285	1	0	0	0	0	0	0	0	1	11256	932	33	2		2	OR6K2	1	158669573	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	28329	158669573	90581048	17	52872											
ARHGAP30	257106	broad.mit.edu	37	chr1	161039369	161039369	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caagtcgcacccaaaaacccGctcctttgcgctgcccttct	8	9	6	18	3	1	0	0	0	1	0	3	0	2	0	4	0	3	3	4	0	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:161039369G>A	uc001fxl.2	-	1	392	c.46C>T	c.(46-48)CGG>TGG	p.R16W	ARHGAP30_uc001fxk.2_Missense_Mutation_p.R16W|ARHGAP30_uc001fxm.2_5'UTR|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_5'UTR	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	16					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CCAAAAACCCGCTCCTTTGCG	0.642													32	61					0	0	0	0	A	161039369	A	A	161039369	3	1	285	1	0	0	0	0	1	0	0	0	879	1086	38	1	3307	1	ARHGAP30	1	161039369	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2369796	161039369	88211252	18	52873											
C1orf114	57821	broad.mit.edu	37	chr1	169391451	169391451	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttggtgagacctcatccTgcaaagatttgtcaggatca	10	13	9	9	0	4	2	3	1	1	2	5	4	5	3	2	2	1	1	2	2	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:169391451T>A	uc001gga.1	-	3	386	c.218A>T	c.(217-219)CAG>CTG	p.Q73L	C1orf114_uc001gfz.1_Missense_Mutation_p.Q73L|C1orf114_uc009wvq.1_Missense_Mutation_p.Q73L|C1orf114_uc001ggb.2_Missense_Mutation_p.Q73L|C1orf114_uc001ggc.1_Missense_Mutation_p.Q73L	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	73											0	all_hematologic(923;0.208)					GACCTCATCCTGCAAAGATTT	0.398													28	26					0	0	0	0	A	169391451	A	A	169391451	3	1	285	1	0	0	0	0	1	0	0	0	1996	1580	55	5	1324	5	C1orf114	1	169391451	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	8352082	169391451	79859170	19	52874											
F5	2153	broad.mit.edu	37	chr1	169505920	169505920	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcttcaatatctgtttcccTgaaataataatactatttgt	12	18	4	7	0	3	1	1	1	2	0	4	1	4	1	1	0	1	1	1	0	7	8			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:169505920T>C	uc001ggg.1	-	14	4942	c.4797_splice	c.e14-1	p.R1599_splice		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor						cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCTGTTTCCCTGAAATAATAA	0.269													19	37					0	0	0	0	C	169505920	C	C	169505920	5	2	285	1	0	0	0	0	0	0	1	0	5373	1594	55	5	1927	5	F5	1	169505920	Splice_Site	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	114469	169505920	79744701	20	52875											
FASLG	356	broad.mit.edu	37	chr1	172628386	172628386	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatccccagatctactgggtGgacagcagtgccagctctcc	8	9	10	14	0	2	1	0	0	2	1	4	2	3	2	4	2	4	2	4	2	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:172628386G>C	uc001gis.2	+	1	202	c.45G>C	c.(43-45)GTG>GTC	p.V15V	FASLG_uc001git.2_Silent_p.V15V	NM_000639	NP_000630	P48023	TNFL6_HUMAN	fas ligand	15	Pro-rich.|Cytoplasmic (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3						TCTACTGGGTGGACAGCAGTG	0.547													5	61					0	0	0	0	C	172628386	C	C	172628386	2	2	285	1	0	0	0	0	0	0	0	1	5714	1335	47	4		4	FASLG	1	172628386	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	3122466	172628386	76622235	21	52876											
TNFSF4	7292	broad.mit.edu	37	chr1	173157708	173157708	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcgaggataccgatgtgataCctgagggaggaagaaagaca	15	6	14	6	2	0	4	0	2	0	2	1	9	0	7	2	3	2	0	2	3	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:173157708C>G	uc001giw.2	-	2	310	c.154G>C	c.(154-156)GTA>CTA	p.V52L	TNFSF4_uc001giv.2_Missense_Mutation_p.V2L	NM_003326	NP_003317	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily,	52	Extracellular (Potential).				acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			central_nervous_system(1)	1						CGATGTGATACCTGAGGGAGG	0.328													17	99					0	0	0	0	G	173157708	G	G	173157708	3	3	285	1	0	0	0	0	1	0	0	0	16376	521	18	4	405	4	TNFSF4	1	173157708	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	529322	173157708	76092913	22	52877											
TNR	7143	broad.mit.edu	37	chr1	175306678	175306678	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttacaatccagccgccccCgtcggtggtcatatcacagt	9	9	8	15	3	2	0	2	0	0	0	4	0	3	0	4	2	2	0	4	2	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:175306678C>A	uc001gkp.1	-	17	3601	c.3520G>T	c.(3520-3522)GGG>TGG	p.G1174W	TNR_uc009wwu.1_Missense_Mutation_p.G1174W	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1174	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CAGCCGCCCCCGTCGGTGGTC	0.507													35	52					2.87052e-16	3.57626e-16	1	0	A	175306678	A	A	175306678	3	1	285	1	0	0	0	0	1	0	0	0	16404	652	23	3	576	3	TNR	1	175306678	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2148970	175306678	73943943	23	52878											
RFWD2	64326	broad.mit.edu	37	chr1	176012927	176012927	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcactgctagctaacaggttCttatggtaactactccaact	11	13	6	11	0	2	0	1	0	1	0	3	0	3	0	1	2	6	4	1	2	6	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:176012927C>G	uc001gku.1	-	13	1705	c.1449G>C	c.(1447-1449)AAG>AAC	p.K483N	RFWD2_uc001gkv.1_Missense_Mutation_p.K459N|RFWD2_uc001gkw.1_Missense_Mutation_p.K243N|RFWD2_uc009wwv.2_Missense_Mutation_p.K282N|RFWD2_uc001gkt.1_Missense_Mutation_p.K322N	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	483	WD 2.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						CTAACAGGTTCTTATGGTAAC	0.323													55	276					0	0	0	0	G	176012927	G	G	176012927	3	3	285	1	0	0	0	0	1	0	0	0	13325	912	32	2	778	2	RFWD2	1	176012927	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	706249	176012927	73237694	24	52879											
HMCN1	83872	broad.mit.edu	37	chr1	185939517	185939517	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcattattgaccctctcttgGgacttttgaagattcaagaa	11	15	7	8	0	3	4	2	2	1	2	4	5	3	5	1	1	0	0	1	1	4	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:185939517G>T	uc001grq.1	+	15	2492	c.2263G>T	c.(2263-2265)GGA>TGA	p.G755*	HMCN1_uc001grr.1_Nonsense_Mutation_p.G96*	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	755	Ig-like C2-type 4.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CCCTCTCTTGGGACTTTTGAA	0.408													84	191					7.68447e-34	1.0763e-33	1	0	T	185939517	T	T	185939517	4	4	285	1	0	0	0	0	0	1	0	0	7259	1233	43	4	2321	4	HMCN1	1	185939517	Nonsense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	9926590	185939517	63311104	25	52880											
PTPN7	5778	broad.mit.edu	37	chr1	202121728	202121728	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccgggctctcctccacctCtgccactaggcgcagcaggg	5	7	11	18	2	2	0	0	0	2	0	5	0	4	0	5	3	2	3	5	3	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:202121728C>T	uc001gxm.1	-	8	948	c.817G>A	c.(817-819)GAG>AAG	p.E273K	PTPN7_uc001gxl.1_Missense_Mutation_p.E312K|PTPN7_uc001gxn.1_Missense_Mutation_p.E273K|PTPN7_uc010ppv.1_Missense_Mutation_p.E92K|PTPN7_uc010ppw.1_Missense_Mutation_p.E221K|PTPN7_uc010ppx.1_Missense_Mutation_p.E347K|PTPN7_uc010ppy.1_RNA|PTPN7_uc001gxo.1_Missense_Mutation_p.E225K	NM_002832	NP_002823	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type	273	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			skin(1)	1						TCCTCCACCTCTGCCACTAGG	0.642													16	33					0	0	0	0	T	202121728	T	T	202121728	3	4	285	1	0	0	0	0	1	0	0	0	12858	922	32	2	277	2	PTPN7	1	202121728	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	16182211	202121728	47128893	26	52881											
PLEKHA6	22874	broad.mit.edu	37	chr1	204236663	204236663	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcgcttgttccactgcttaaCcccggagctggcctgcggga	5	9	13	14	3	0	0	0	0	0	0	1	2	1	2	4	3	4	4	4	3	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:204236663C>G	uc001hau.2	-	5	537	c.220G>C	c.(220-222)GTT>CTT	p.V74L		NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	74	PH.									ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			CACTGCTTAACCCCGGAGCTG	0.597													18	51					0	0	0	0	G	204236663	G	G	204236663	3	3	285	1	0	0	0	0	1	0	0	0	12115	507	18	4	2998	4	PLEKHA6	1	204236663	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2114935	204236663	45013958	27	52882											
FAIM3	9214	broad.mit.edu	37	chr1	207095236	207095236	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaggtccatccaagagcccCtagagagggggatggagaca	13	4	14	10	0	0	3	0	0	0	3	2	6	2	4	4	4	1	0	4	4	3	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:207095236C>A	uc001hey.2	-	1	143	c.-36G>T	c.(-38--34)TAGGG>TATGG		FAIM3_uc010prz.1_Translation_Start_Site|FAIM3_uc010psa.1_Translation_Start_Site|FAIM3_uc010psb.1_Splice_Site	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a						anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					CCAAGAGCCCCTAGAGAGGGG	0.517													19	34					1.00905e-13	1.22995e-13	1	0	A	207095236	A	A	207095236	1	1	285	1	0	0	0	0	0	0	0	0	5405	695	24	4		4	FAIM3	1	207095236	Translation_Start_Site	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2858573	207095236	42155385	28	52883											
CD34	947	broad.mit.edu	37	chr1	208062192	208062192	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgaaatctaggatccccagCttgaaaagaagacaaagaag	18	6	10	7	0	1	5	0	2	1	3	2	6	2	6	2	1	1	1	2	1	7	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:208062192C>G	uc001hgw.1	-	7	1066	c.808_splice	c.e7-1	p.L270_splice	CD34_uc001hgv.1_Splice_Site_p.L112_splice|CD34_uc001hgx.1_Splice_Site_p.L270_splice|CD34_uc010psj.1_Splice_Site_p.L135_splice	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a						cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						GGATCCCCAGCTTGAAAAGAA	0.527													64	128					0	0	0	0	G	208062192	G	G	208062192	5	3	285	1	0	0	0	0	0	0	1	0	3021	811	28	4	377	4	CD34	1	208062192	Splice_Site	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	966956	208062192	41188429	29	52884											
USH2A	7399	broad.mit.edu	37	chr1	215953214	215953214	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tatgctgtctcctgtcagtgGtgtcagtgtggatgagacct	6	14	13	8	0	3	1	2	1	1	1	4	3	3	2	2	2	1	1	2	2	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:215953214G>A	uc001hku.1	-	55	11297	c.10910C>T	c.(10909-10911)ACC>ATC	p.T3637I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3637	Extracellular (Potential).|Fibronectin type-III 21.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCTGTCAGTGGTGTCAGTGTG	0.498										HNSCC(13;0.011)			52	55					0	0	0	0	A	215953214	A	A	215953214	3	1	285	1	0	0	0	0	1	0	0	0	17104	1261	44	4	4770	4	USH2A	1	215953214	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	7891022	215953214	33297407	30	52885											
USH2A	7399	broad.mit.edu	37	chr1	216040365	216040365	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttacttggtttagcccacctCacgtcgatggctgtgtggtt	5	15	11	10	2	1	0	1	0	0	0	2	1	1	0	2	3	2	3	2	3	2	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:216040365C>A	uc001hku.1	-	44	9216	c.8829G>T	c.(8827-8829)GTG>GTT	p.V2943V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2943	Fibronectin type-III 16.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAGCCCACCTCACGTCGATGG	0.448										HNSCC(13;0.011)			35	57					1.04594e-18	1.35551e-18	1	0	A	216040365	A	A	216040365	2	1	285	1	0	0	0	0	0	0	0	1	17104	813	29	2		2	USH2A	1	216040365	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	87151	216040365	33210256	31	52886											
EPRS	2058	broad.mit.edu	37	chr1	220156625	220156625	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agttttcaacaccaagtttcTtgatctcagcatcaaaaaag	15	12	5	9	0	4	1	3	1	2	0	5	1	4	1	1	0	2	3	1	0	5	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:220156625T>A	uc001hly.1	-	22	3476	c.3206A>T	c.(3205-3207)AAG>ATG	p.K1069M		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1069	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	ACCAAGTTTCTTGATCTCAGC	0.423													53	68					0	0	0	0	A	220156625	A	A	220156625	3	1	285	1	0	0	0	0	1	0	0	0	5215	1609	56	5	1376	5	EPRS	1	220156625	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	4116260	220156625	29093996	32	52887											
GALNT2	2590	broad.mit.edu	37	chr1	230338962	230338962	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccgggcaggacccttacgcCcgcaacaagttcaaccaggt	10	6	10	15	3	1	0	1	0	0	0	2	1	2	1	4	3	3	3	4	3	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:230338962C>G	uc010pwa.1	+	3	372	c.300C>G	c.(298-300)GCC>GCG	p.A100A	GALNT2_uc010pvy.1_Silent_p.A62A|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	100	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				ACCCTTACGCCCGCAACAAGT	0.552													38	114					0	0	0	0	G	230338962	G	G	230338962	2	3	285	1	0	0	0	0	0	0	0	1	6248	610	22	4		4	GALNT2	1	230338962	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	10182337	230338962	18911659	33	52888											
RYR2	6262	broad.mit.edu	37	chr1	237580388	237580388	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgctgtgtctgttcatgcAcgttccctttggagactaga	6	13	12	10	2	2	2	1	0	1	2	3	3	3	2	1	2	1	4	1	2	1	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:237580388A>T	uc001hyl.1	+	11	933	c.813A>T	c.(811-813)GCA>GCT	p.A271A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	271	Cytoplasmic (By similarity).|MIR 3.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGTTCATGCACGTTCCCTTT	0.423													22	32					0	0	0	0	T	237580388	T	T	237580388	2	4	285	1	0	0	0	0	0	0	0	1	13834	146	6	5		5	RYR2	1	237580388	Silent	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	7241426	237580388	11670233	34	52889											
FMN2	56776	broad.mit.edu	37	chr1	240256593	240256593	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctgacgcccccgcggccgCttccctgcccggcagccccg	3	4	11	23	6	0	1	0	1	0	0	1	1	1	1	8	2	2	2	8	2	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:240256593C>T	uc010pyd.1	+	1	1409	c.1184C>T	c.(1183-1185)GCT>GTT	p.A395V	FMN2_uc010pye.1_Missense_Mutation_p.A395V	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	395					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCGCGGCCGCTTCCCTGCCC	0.726													21	17					0	0	0	0	T	240256593	T	T	240256593	3	4	285	1	0	0	0	0	1	0	0	0	5982	797	28	4	1186	4	FMN2	1	240256593	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2676205	240256593	8994028	35	52890											
RGS7	6000	broad.mit.edu	37	chr1	240966253	240966253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggcactggatcttataaaaCgtgggtatgaatcacttttc	12	13	9	7	1	2	1	1	1	1	0	3	2	2	2	0	3	1	2	0	3	5	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:240966253C>T	uc001hyv.2	-	16	1640	c.1310G>A	c.(1309-1311)CGT>CAT	p.R437H	RGS7_uc010pyh.1_Missense_Mutation_p.R411H|RGS7_uc010pyj.1_Missense_Mutation_p.R353H|RGS7_uc001hyu.2_Missense_Mutation_p.R437H|RGS7_uc009xgn.1_Missense_Mutation_p.R384H|RGS7_uc001hyw.2_Missense_Mutation_p.R437H|RGS7_uc001hyt.2_Missense_Mutation_p.R269H	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	437	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCTTATAAAACGTGGGTATGA	0.343													54	80					0	0	0	0	T	240966253	T	T	240966253	3	4	285	1	0	0	0	0	1	0	0	0	13375	536	19	1	165	1	RGS7	1	240966253	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	709660	240966253	8284368	36	52891											
RGS7	6000	broad.mit.edu	37	chr1	240975331	240975331	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	catcgttttaccctctgctgGctcggttctttgctatagaa	6	16	8	11	2	2	1	0	0	2	1	4	1	2	1	1	2	3	5	1	2	4	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:240975331G>T	uc001hyv.2	-	14	1299	c.969C>A	c.(967-969)AGC>AGA	p.S323R	RGS7_uc010pyh.1_Missense_Mutation_p.S297R|RGS7_uc010pyj.1_Missense_Mutation_p.S239R|RGS7_uc001hyu.2_Missense_Mutation_p.S323R|RGS7_uc009xgn.1_Missense_Mutation_p.S270R|RGS7_uc001hyw.2_Missense_Mutation_p.S323R|RGS7_uc001hyt.2_Missense_Mutation_p.S155R	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	323					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CCCTCTGCTGGCTCGGTTCTT	0.393													38	58					1.49673e-21	1.97376e-21	1	0	T	240975331	T	T	240975331	3	4	285	1	0	0	0	0	1	0	0	0	13375	1194	42	4	514	4	RGS7	1	240975331	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	9078	240975331	8275290	37	52892											
OR6F1	343169	broad.mit.edu	37	chr1	247875907	247875907	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtatgcaactgatgggaggTgctcaccaacatcaagatag	13	8	12	8	0	2	2	2	1	0	1	2	3	2	3	1	3	4	3	1	3	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr1:247875907T>G	uc001idj.1	-	1	151	c.151A>C	c.(151-153)ACC>CCC	p.T51P		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGATGGGAGGTGCTCACCAAC	0.473													41	80					0	0	0	0	G	247875907	G	G	247875907	3	3	285	1	0	0	0	0	1	0	0	0	11255	1696	59	5	779	5	OR6F1	1	247875907	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	6900576	247875907	1374714	38	52893											
TTC15	51112	broad.mit.edu	37	chr2	3469391	3469391	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatgtgctggccgtggaggcGtatcattcggttatcaagta	8	13	13	7	3	2	0	2	0	0	0	3	1	2	1	1	4	1	4	1	4	5	5	rs116179331	byFrequency	TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:3469391G>C	uc002qxm.1	+	9	1907	c.1701G>C	c.(1699-1701)GCG>GCC	p.A567A	TTC15_uc002qxn.1_Silent_p.A567A|TTC15_uc010ewm.1_Silent_p.A573A	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	567	TPR 1.						binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		CCGTGGAGGCGTATCATTCGG	0.527													53	67					0	0	0	0	C	3469391	C	C	3469391	2	2	285	1	0	0	0	0	0	0	0	1	16750	1132	40	3		3	TTC15	2	3469391	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08		3469391	239729982	39	52894											
FOSL2	2355	broad.mit.edu	37	chr2	28634831	28634831	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggaggagaagtcaggccTgcagaaggagattgctgagc	12	5	18	6	0	1	4	1	1	0	3	1	8	1	6	1	5	3	2	1	5	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:28634831T>C	uc002rma.2	+	4	1306	c.497T>C	c.(496-498)CTG>CCG	p.L166P	FOSL2_uc010ymi.1_Missense_Mutation_p.L127P	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	166	Leucine-zipper.				cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					AAGTCAGGCCTGCAGAAGGAG	0.582													3	58					0	0	0	0	C	28634831	C	C	28634831	3	2	285	1	0	0	0	0	1	0	0	0	6020	1580	55	5	511	5	FOSL2	2	28634831	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	25165440	28634831	214564542	40	52895											
VRK2	7444	broad.mit.edu	37	chr2	58373570	58373570	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acatggaaagtgcagaaagaGgagaaactgattggattgat	17	8	13	3	0	0	5	0	2	0	3	0	8	0	7	0	3	2	1	0	3	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:58373570G>T	uc002rzo.2	+	15	1888	c.1143G>T	c.(1141-1143)GAG>GAT	p.E381D	VRK2_uc010fcb.2_Missense_Mutation_p.E381D|VRK2_uc002rzs.2_Missense_Mutation_p.E381D|VRK2_uc002rzr.2_Missense_Mutation_p.E381D|VRK2_uc010fcc.2_Missense_Mutation_p.E263D|VRK2_uc002rzv.2_Missense_Mutation_p.E381D|VRK2_uc010fcd.2_Missense_Mutation_p.E358D|VRK2_uc002rzp.2_Missense_Mutation_p.E381D|VRK2_uc010ypg.1_Missense_Mutation_p.E381D|VRK2_uc002rzq.2_Missense_Mutation_p.E381D|VRK2_uc002rzu.2_Missense_Mutation_p.E381D|VRK2_uc002rzt.2_Missense_Mutation_p.E263D	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	vaccinia related kinase 2 isoform 2	381						integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						TGCAGAAAGAGGAGAAACTGA	0.403													11	40					2.80697e-09	3.18077e-09	1	0	T	58373570	T	T	58373570	3	4	285	1	0	0	0	0	1	0	0	0	17288	991	35	4	1185	4	VRK2	2	58373570	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	29738739	58373570	184825803	41	52896											
ALMS1	7840	broad.mit.edu	37	chr2	73718480	73718480	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaagtcgtacagccttctCttccagacagtaacactatt	11	12	5	13	1	1	1	0	0	1	1	5	1	3	1	3	0	3	2	3	0	4	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:73718480C>T	uc002sje.1	+	12	9508	c.9397C>T	c.(9397-9399)CTT>TTT	p.L3133F	ALMS1_uc002sjf.1_Missense_Mutation_p.L3089F|ALMS1_uc002sjg.2_Missense_Mutation_p.L2519F|ALMS1_uc002sjh.1_Missense_Mutation_p.L2519F	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3131					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						ACAGCCTTCTCTTCCAGACAG	0.393													42	67					0	0	0	0	T	73718480	T	T	73718480	3	4	285	1	0	0	0	0	1	0	0	0	535	913	32	2	9429	2	ALMS1	2	73718480	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	15344910	73718480	169480893	42	52897											
MOGS	7841	broad.mit.edu	37	chr2	74691753	74691753	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaaggagaggccgtcgtggAactcccagccatagggaccc	10	4	14	13	3	0	1	0	0	0	1	2	5	1	3	4	4	2	0	4	4	3	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:74691753A>C	uc010ffj.2	-	2	612	c.449T>G	c.(448-450)TTC>TGC	p.F150C	MOGS_uc010ffh.2_5'Flank|MOGS_uc010yrt.1_Missense_Mutation_p.F31C|MOGS_uc010ffi.2_Missense_Mutation_p.F44C|MOGS_uc010yru.1_Intron	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	150	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						GCCGTCGTGGAACTCCCAGCC	0.657													26	55					0	0	0	0	C	74691753	C	C	74691753	3	2	285	1	0	0	0	0	1	0	0	0	9750	246	9	5	2076	5	MOGS	2	74691753	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	973273	74691753	168507620	43	52898											
FAM176A	84141	broad.mit.edu	37	chr2	75720630	75720630	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcttcccgggacgccgcCtgcagtctgtgtggcaagag	6	9	13	13	3	2	1	0	0	2	1	3	2	3	2	3	2	1	2	3	2	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:75720630C>T	uc002sni.2	-	4	669	c.191G>A	c.(190-192)AGG>AAG	p.R64K	FAM176A_uc002snj.1_Missense_Mutation_p.R51K|FAM176A_uc002snk.1_Missense_Mutation_p.R64K	NM_001135032	NP_001128504	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	64					apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0						GGGACGCCGCCTGCAGTCTGT	0.607													25	29					0	0	0	0	T	75720630	T	T	75720630	3	4	285	1	0	0	0	0	1	0	0	0	5527	681	24	4	271	4	FAM176A	2	75720630	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1028877	75720630	167478743	44	52899											
SNRNP200	23020	broad.mit.edu	37	chr2	96963242	96963242	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgggtaaaaaccaggtcCtccaagtccagaacctgccg	11	7	9	14	1	0	1	0	0	0	1	3	1	3	1	7	2	3	1	7	2	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:96963242C>A	uc002svu.2	-	11	1322	c.1236G>T	c.(1234-1236)GAG>GAT	p.E412D		NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	412						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						AAACCAGGTCCTCCAAGTCCA	0.512													11	18					5.16669e-11	6.09994e-11	1	0	A	96963242	A	A	96963242	3	1	285	1	0	0	0	0	1	0	0	0	14916	680	24	4	5314	4	SNRNP200	2	96963242	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	21242612	96963242	146236131	45	52900											
ANKRD36	375248	broad.mit.edu	37	chr2	97869830	97869830	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgagaaaccaccaggcttGaaggtaatgaaactgtcgtt	13	10	10	8	1	1	3	0	3	1	1	2	4	1	3	2	2	2	3	2	2	4	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:97869830G>C	uc010yva.1	+	49	3229	c.2985G>C	c.(2983-2985)TTG>TTC	p.L995F	ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	995											0						CACCAGGCTTGAAGGTAATGA	0.308													4	11					0	0	0	0	C	97869830	C	C	97869830	3	2	285	1	0	0	0	0	1	0	0	0	665	1281	45	2	3179	2	ANKRD36	2	97869830	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	906588	97869830	145329543	46	52901											
ANAPC1	64682	broad.mit.edu	37	chr2	112541901	112541901	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaccacacccagcttaccTgctttaaaagatggagttct	11	10	7	13	1	1	1	0	0	1	1	1	3	1	2	4	1	3	3	4	1	3	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:112541901T>A	uc002thi.2	-	41	5241	c.4994A>T	c.(4993-4995)CAG>CTG	p.Q1665L		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	1665					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						CCAGCTTACCTGCTTTAAAAG	0.438													37	138					0	0	0	0	A	112541901	A	A	112541901	3	1	285	1	0	0	0	0	1	0	0	0	598	1594	55	5	872	5	ANAPC1	2	112541901	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	14672071	112541901	130657472	47	52902											
TFCP2L1	29842	broad.mit.edu	37	chr2	121995390	121995390	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acacttacgtcactgcccacGggcagggcctccaccgggtg	7	6	12	16	3	1	0	1	0	0	0	2	0	2	0	4	3	2	1	4	3	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:121995390G>A	uc002tmx.2	-	9	990	c.897C>T	c.(895-897)CCC>CCT	p.P299P	TFCP2L1_uc010flr.2_Silent_p.P299P	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	299					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					CACTGCCCACGGGCAGGGCCT	0.652													13	22					0	0	0	0	A	121995390	A	A	121995390	2	1	285	1	0	0	0	0	0	0	0	1	15862	1103	39	1		1	TFCP2L1	2	121995390	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	9453489	121995390	121203983	48	52903											
NCKAP5	344148	broad.mit.edu	37	chr2	133721320	133721320	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctttcaatctctctaatagCaatttggtcttttcttttcc	7	20	4	10	0	5	0	1	0	4	0	7	0	6	0	1	1	1	2	1	1	4	8			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:133721320C>T	uc002ttp.2	-	8	926	c.552G>A	c.(550-552)TTG>TTA	p.L184L	NCKAP5_uc002ttq.2_Silent_p.L184L|NCKAP5_uc002tts.1_Silent_p.L159L	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	184	Potential.						protein binding				0						TCTCTAATAGCAATTTGGTCT	0.368													48	102					0	0	0	0	T	133721320	T	T	133721320	2	4	285	1	0	0	0	0	0	0	0	1	10277	709	25	4		4	NCKAP5	2	133721320	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	11725930	133721320	109478053	49	52904											
TANC1	85461	broad.mit.edu	37	chr2	160035608	160035608	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aacccgcatgttctgccaccCgtccttcagggagtggcttg	6	10	11	14	2	2	0	1	0	1	0	3	1	3	1	4	2	2	3	4	2	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:160035608C>T	uc002uag.2	+	14	2718	c.2444C>T	c.(2443-2445)CCG>CTG	p.P815L	TANC1_uc010fol.1_Missense_Mutation_p.P709L|TANC1_uc010zcm.1_Missense_Mutation_p.P807L|TANC1_uc010fom.1_Missense_Mutation_p.P621L|TANC1_uc002uai.1_RNA	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	815						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TTCTGCCACCCGTCCTTCAGG	0.577													45	73					0	0	0	0	T	160035608	T	T	160035608	3	4	285	1	0	0	0	0	1	0	0	0	15610	652	23	1	2490	1	TANC1	2	160035608	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	26314288	160035608	83163765	50	52905											
KCNH7	90134	broad.mit.edu	37	chr2	163374347	163374347	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacataagctttcccttgatCtggaatgggacagctgggaa	11	11	11	8	0	1	1	0	1	1	0	2	4	2	4	1	3	3	2	1	3	4	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:163374347C>A	uc002uch.1	-	4	997	c.785G>T	c.(784-786)AGA>ATA	p.R262I	KCNH7_uc002uci.2_Missense_Mutation_p.R262I	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	262	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TTCCCTTGATCTGGAATGGGA	0.493													42	56					4.32679e-17	5.48141e-17	1	0	A	163374347	A	A	163374347	3	1	285	1	0	0	0	0	1	0	0	0	8076	913	32	2	2923	2	KCNH7	2	163374347	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	3338739	163374347	79825026	51	52906											
KCNH7	90134	broad.mit.edu	37	chr2	163393462	163393462	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agttttgattggtaatattgGgtttaccctctctggggtgg	6	17	13	5	0	1	1	0	1	1	0	2	1	1	1	1	5	1	3	1	5	3	8			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:163393462G>T	uc002uch.1	-	3	648	c.436C>A	c.(436-438)CCA>ACA	p.P146T	KCNH7_uc002uci.2_Missense_Mutation_p.P146T	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	146	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	GGTAATATTGGGTTTACCCTC	0.378													63	98					1.84395e-34	2.59072e-34	1	0	T	163393462	T	T	163393462	3	4	285	1	0	0	0	0	1	0	0	0	8076	1232	43	4	3276	4	KCNH7	2	163393462	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	19115	163393462	79805911	52	52907											
ABCB11	8647	broad.mit.edu	37	chr2	169780147	169780147	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgggtcaactgatgggggaTccagtggtgactagtttgta	8	13	15	5	0	1	2	1	2	0	0	2	3	2	3	1	4	1	2	1	4	3	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:169780147T>C	uc002ueo.1	-	28	4077	c.3951A>G	c.(3949-3951)GGA>GGG	p.G1317G	ABCB11_uc010zda.1_Silent_p.G735G|ABCB11_uc010zdb.1_Silent_p.G793G	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1317	Cytoplasmic (Potential).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TGATGGGGGATCCAGTGGTGA	0.468													19	58					0	0	0	0	C	169780147	C	C	169780147	2	2	285	1	0	0	0	0	0	0	0	1	42	1422	50	5		5	ABCB11	2	169780147	Silent	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	6386685	169780147	73419226	53	52908											
EVX2	344191	broad.mit.edu	37	chr2	176947080	176947080	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccggagccacccagcgccgcGctcccgccgctgcctccgct	3	4	11	23	7	0	0	0	0	0	0	2	1	2	1	8	1	3	3	8	1	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:176947080G>T	uc010zeu.1	-	2	711	c.525C>A	c.(523-525)AGC>AGA	p.S175R		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	175						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CCAGCGCCGCGCTCCCGCCGC	0.721													9	21					1.58986e-06	1.72778e-06	1	0	T	176947080	T	T	176947080	3	4	285	1	0	0	0	0	1	0	0	0	5319	1078	38	3	911	3	EVX2	2	176947080	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	7166933	176947080	66252293	54	52909											
TTN	7273	broad.mit.edu	37	chr2	179466061	179466061	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aataccaaaacggttttctgCtcgcacacggaagaaatatt	15	10	7	9	3	1	1	0	0	1	1	2	2	1	2	1	2	3	3	1	2	7	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:179466061C>T	uc010zfg.1	-	236	48183	c.47959G>A	c.(47959-47961)GCA>ACA	p.A15987T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A9682T|TTN_uc010zfi.1_Missense_Mutation_p.A9615T|TTN_uc010zfj.1_Missense_Mutation_p.A9490T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16914							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGTTTTCTGCTCGCACACGG	0.433													30	51					0	0	0	0	T	179466061	T	T	179466061	3	4	285	1	0	0	0	0	1	0	0	0	16803	797	28	4	52334	4	TTN	2	179466061	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2518981	179466061	63733312	55	52910											
TTN	7273	broad.mit.edu	37	chr2	179578646	179578646	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaaacctgcaatgaagctgtGcagctgtctttgccaacagg	11	9	11	10	0	1	1	0	1	1	0	1	2	1	1	2	1	7	4	2	1	4	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:179578646G>T	uc010zfg.1	-	89	23231	c.23007C>A	c.(23005-23007)TGC>TGA	p.C7669*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.C4330*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8596							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGAAGCTGTGCAGCTGTCTT	0.408													25	35					5.61819e-17	7.09749e-17	1	0	T	179578646	T	T	179578646	4	4	285	1	0	0	0	0	0	1	0	0	16803	1311	46	4	77874	4	TTN	2	179578646	Nonsense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	112585	179578646	63620727	56	52911											
TTN	7273	broad.mit.edu	37	chr2	179587165	179587165	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccatctctataccagcacActtggatgggtgcagagcca	10	9	9	13	0	1	1	0	0	1	1	3	2	2	2	3	2	4	2	3	2	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:179587165A>T	uc010zfg.1	-	74	18841	c.18617T>A	c.(18616-18618)GTG>GAG	p.V6206E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V2867E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7133							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACCAGCACACTTGGATGGG	0.388													63	82					0	0	0	0	T	179587165	T	T	179587165	3	4	285	1	0	0	0	0	1	0	0	0	16803	159	6	5	82324	5	TTN	2	179587165	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	8519	179587165	63612208	57	52912											
TTN	7273	broad.mit.edu	37	chr2	179611834	179611834	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctctagagtctctcctgggGgtgtggagtatctctccaga	6	12	13	10	0	3	2	0	0	3	2	7	3	5	3	2	3	0	2	2	3	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:179611834G>A	uc002unb.2	-	46	15517	c.15293C>T	c.(15292-15294)CCC>CTC	p.P5098L	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTCCTGGGGGTGTGGAGTA	0.522													58	89					0	0	0	0	A	179611834	A	A	179611834	3	1	285	1	0	0	0	0	1	0	0	0	16803	1232	43	4	95004	4	TTN	2	179611834	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	24669	179611834	63587539	58	52913											
TTN	7273	broad.mit.edu	37	chr2	179612195	179612195	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taactcagatatttcttcacTggttgtacttcccacaccaa	11	14	4	12	0	3	1	2	0	1	1	4	1	4	1	2	1	2	2	2	1	4	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:179612195T>C	uc002unb.2	-	46	15156	c.14932A>G	c.(14932-14934)AGT>GGT	p.S4978G	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTCTTCACTGGTTGTACTT	0.383													34	92					0	0	0	0	C	179612195	C	C	179612195	3	2	285	1	0	0	0	0	1	0	0	0	16803	1580	55	5	95365	5	TTN	2	179612195	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	361	179612195	63587178	59	52914											
TTN	7273	broad.mit.edu	37	chr2	179613197	179613197	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggaattttttctttataatGtatttcctgctgttccctag	8	20	6	7	0	1	0	0	0	1	0	3	1	3	1	2	1	1	3	2	1	5	10			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:179613197G>A	uc002unb.2	-	46	14154	c.13930C>T	c.(13930-13932)CAT>TAT	p.H4644Y	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	758							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTATAATGTATTTCCTGC	0.358													67	124					0	0	0	0	A	179613197	A	A	179613197	3	1	285	1	0	0	0	0	1	0	0	0	16803	1377	48	4	96367	4	TTN	2	179613197	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1002	179613197	63586176	60	52915											
TTN	7273	broad.mit.edu	37	chr2	179639115	179639115	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattttccttctatattttcTggggatacaatgcactctaa	10	17	5	9	0	3	0	0	0	3	0	4	1	4	1	1	2	2	1	1	2	5	9			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:179639115T>C	uc010zfg.1	-	30	7100	c.6876A>G	c.(6874-6876)CCA>CCG	p.P2292P	TTN_uc010zfh.1_Silent_p.P2246P|TTN_uc010zfi.1_Silent_p.P2246P|TTN_uc010zfj.1_Silent_p.P2246P|TTN_uc002unb.2_Silent_p.P2292P|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2292							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTATATTTTCTGGGGATACAA	0.383													60	95					0	0	0	0	C	179639115	C	C	179639115	2	2	285	1	0	0	0	0	0	0	0	1	16803	1567	55	5		5	TTN	2	179639115	Silent	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	25918	179639115	63560258	61	52916											
DNAH7	56171	broad.mit.edu	37	chr2	196891496	196891496	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caatttacctatggatttccTtacactaagaagataatcct	14	14	4	9	0	0	2	0	0	0	2	2	3	2	3	3	1	2	0	3	1	7	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:196891496T>A	uc002utj.3	-	7	756	c.655A>T	c.(655-657)AGG>TGG	p.R219W		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	219	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATGGATTTCCTTACACTAAGA	0.294													8	23					0	0	0	0	A	196891496	A	A	196891496	3	1	285	1	0	0	0	0	1	0	0	0	4628	1608	56	5	11655	5	DNAH7	2	196891496	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	17252381	196891496	46307877	62	52917											
ERBB4	2066	broad.mit.edu	37	chr2	212495206	212495206	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctgtttccaagaatcttCtcaaggctcttttctttttg	6	19	5	11	0	5	1	1	0	5	1	7	1	6	1	2	1	0	2	2	1	3	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:212495206C>A	uc002veg.1	-	17	2158	c.2060G>T	c.(2059-2061)AGA>ATA	p.R687I	ERBB4_uc002veh.1_Missense_Mutation_p.R687I|ERBB4_uc010zji.1_Missense_Mutation_p.R677I|ERBB4_uc010zjj.1_Missense_Mutation_p.R677I|ERBB4_uc010fut.1_Missense_Mutation_p.R687I	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	687	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CAAGAATCTTCTCAAGGCTCT	0.388										TSP Lung(8;0.080)			25	75					3.08376e-08	3.43402e-08	1	0	A	212495206	A	A	212495206	3	1	285	1	0	0	0	0	1	0	0	0	5233	913	32	2	1914	2	ERBB4	2	212495206	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	15603710	212495206	30704167	63	52918											
SPHKAP	80309	broad.mit.edu	37	chr2	228884000	228884000	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggggaaagttcgagaccaCttgctccattttgagtcttt	8	14	11	8	1	1	2	0	1	1	1	3	4	2	3	2	2	1	2	2	2	1	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr2:228884000C>G	uc002vpq.2	-	7	1617	c.1570G>C	c.(1570-1572)GTG>CTG	p.V524L	SPHKAP_uc002vpp.2_Missense_Mutation_p.V524L|SPHKAP_uc010zlx.1_Missense_Mutation_p.V524L	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	524						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCGAGACCACTTGCTCCATT	0.512													30	16					0	0	0	0	G	228884000	G	G	228884000	3	3	285	1	0	0	0	0	1	0	0	0	15114	565	20	4	3556	4	SPHKAP	2	228884000	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	16388794	228884000	14315373	64	52919											
CAND2	23066	broad.mit.edu	37	chr3	12868994	12868994	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggctggacgtgcggaaggCggcctttgaatgcatgtatt	7	11	16	7	3	0	1	0	1	0	0	0	3	0	3	1	5	2	3	1	5	3	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:12868994C>T	uc003bxk.2	+	13	3315	c.3266C>T	c.(3265-3267)GCG>GTG	p.A1089V	CAND2_uc003bxj.2_Missense_Mutation_p.A972V	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	1089					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						GTGCGGAAGGCGGCCTTTGAA	0.562													3	41					0	0	0	0	T	12868994	T	T	12868994	3	4	285	1	0	0	0	0	1	0	0	0	2628	768	27	1	3316	1	CAND2	3	12868994	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		12868994	185153436	65	52920											
EPM2AIP1	9852	broad.mit.edu	37	chr3	37034472	37034472	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gcacagggccccatcgccctCcggaggctccaccaccaaat	9	4	9	19	2	0	0	0	0	0	0	3	1	2	1	7	3	0	2	7	3	1	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:37034472C>A	uc003cgk.2	-	1	324	c.97G>T	c.(97-99)GAG>TAG	p.E33*	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	33						endoplasmic reticulum					0						CCATCGCCCTCCGGAGGCTCC	0.607													23	15					3.83957e-06	4.14269e-06	1	0	A	37034472	A	A	37034472	4	1	285	1	0	0	0	0	0	1	0	0	5208	864	30	2	1730	2	EPM2AIP1	3	37034472	Nonsense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	24165478	37034472	160987958	66	52921											
ZDHHC3	51304	broad.mit.edu	37	chr3	45000811	45000811	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcgatgccacagccgtcacGgataaaccacatggttccca	11	6	10	14	3	1	0	1	0	0	0	2	2	2	1	4	3	3	1	4	3	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:45000811G>A	uc003cod.2	-	2	392	c.118C>T	c.(118-120)CGT>TGT	p.R40C	ZDHHC3_uc003cog.2_Missense_Mutation_p.R40C|ZDHHC3_uc011bad.1_Missense_Mutation_p.R40C	NM_016598	NP_057682	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3 isoform 2	40	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		CAGCCGTCACGGATAAACCAC	0.547													45	36					0	0	0	0	A	45000811	A	A	45000811	3	1	285	1	0	0	0	0	1	0	0	0	17683	1116	39	1	1146	1	ZDHHC3	3	45000811	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	7966339	45000811	153021619	67	52922											
DOCK3	1795	broad.mit.edu	37	chr3	51399418	51399418	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcctgaggacctgtaccAccacatgcaggtacagagct	10	8	10	13	0	0	2	0	1	0	1	1	3	1	3	4	2	5	5	4	2	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:51399418A>T	uc011bds.1	+	48	5158	c.5135A>T	c.(5134-5136)CAC>CTC	p.H1712L		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1712						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GACCTGTACCACCACATGCAG	0.552													9	5					0	0	0	0	T	51399418	T	T	51399418	3	4	285	1	0	0	0	0	1	0	0	0	4710	159	6	5	5325	5	DOCK3	3	51399418	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	6398607	51399418	146623012	68	52923											
ROBO1	6091	broad.mit.edu	37	chr3	78701019	78701019	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccggctgcttcaccacaTctgaaatctgctgagcgagg	9	8	12	12	2	3	2	1	2	2	0	3	3	3	2	2	3	3	3	2	3	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:78701019T>A	uc003dqe.2	-	19	2883	c.2675A>T	c.(2674-2676)GAT>GTT	p.D892V	ROBO1_uc003dqb.2_Missense_Mutation_p.D853V|ROBO1_uc003dqc.2_Missense_Mutation_p.D856V|ROBO1_uc003dqd.2_Missense_Mutation_p.D856V|ROBO1_uc010hoh.2_Missense_Mutation_p.D84V|ROBO1_uc011bgl.1_Missense_Mutation_p.D464V	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	892	Extracellular (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CTTCACCACATCTGAAATCTG	0.498													51	39					0	0	0	0	A	78701019	A	A	78701019	3	1	285	1	0	0	0	0	1	0	0	0	13578	1435	50	5	2332	5	ROBO1	3	78701019	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	27301601	78701019	119321411	69	52924											
CADM2	253559	broad.mit.edu	37	chr3	85984983	85984983	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacagcctttaattttgaCttgtgaatccaaaggaaaac	15	11	8	7	0	0	2	0	2	0	0	1	4	1	4	2	2	2	0	2	2	5	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:85984983C>A	uc003dqj.2	+	6	1366	c.740C>A	c.(739-741)ACT>AAT	p.T247N	CADM2_uc003dqk.2_Missense_Mutation_p.T256N|CADM2_uc003dql.2_Missense_Mutation_p.T249N	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	247	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TTAATTTTGACTTGTGAATCC	0.308													57	43					6.12789e-21	8.03395e-21	1	0	A	85984983	A	A	85984983	3	1	285	1	0	0	0	0	1	0	0	0	2579	565	20	4	833	4	CADM2	3	85984983	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	7283964	85984983	112037447	70	52925											
CRYBG3	131544	broad.mit.edu	37	chr3	97596761	97596761	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtgcttatcatcagtatctGcagacttcccaaagtcattc	11	13	6	11	0	4	1	3	0	1	1	6	1	5	1	1	0	2	3	1	0	3	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:97596761G>T	uc003drx.2	+	1	943	c.879G>T	c.(877-879)CTG>CTT	p.L293L		NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						ATCAGTATCTGCAGACTTCCC	0.418													10	56					7.03913e-09	7.91682e-09	1	0	T	97596761	T	T	97596761	2	4	285	1	0	0	0	0	0	0	0	1	3928	1306	46	4		4	CRYBG3	3	97596761	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	11611778	97596761	100425669	71	52926											
ZBTB11	27107	broad.mit.edu	37	chr3	101390839	101390839	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaaacacaagttcatgttTggatactggcttcttttttg	10	17	7	7	0	2	0	1	0	1	0	2	1	2	1	0	2	3	3	0	2	4	8			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:101390839T>A	uc003dve.3	-	2	759	c.529A>T	c.(529-531)AAA>TAA	p.K177*	ZBTB11_uc003dvf.2_Nonsense_Mutation_p.K177*	NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						AGTTCATGTTTGGATACTGGC	0.388													14	59					0	0	0	0	A	101390839	A	A	101390839	4	1	285	1	0	0	0	0	0	1	0	0	17591	1821	63	5	2672	5	ZBTB11	3	101390839	Nonsense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	3794078	101390839	96631591	72	52927											
DZIP3	9666	broad.mit.edu	37	chr3	108335438	108335438	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggaaattgttcctgctttGactttacgtttcttgattac	8	18	8	7	1	1	2	0	2	1	0	2	4	2	3	1	1	3	3	1	1	3	8			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:108335438G>A	uc003dxd.2	+	5	731	c.309G>A	c.(307-309)TTG>TTA	p.L103L	DZIP3_uc003dxf.1_Silent_p.L103L|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Silent_p.L103L	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	103					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TTCCTGCTTTGACTTTACGTT	0.353													20	62					0	0	0	0	A	108335438	A	A	108335438	2	1	285	1	0	0	0	0	0	0	0	1	4887	1281	45	2		2	DZIP3	3	108335438	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	6944599	108335438	89686992	73	52928											
POLQ	10721	broad.mit.edu	37	chr3	121260261	121260261	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aataaacaaagctttcttccGcatttccaaaacccgcttca	14	11	3	13	2	2	0	1	0	1	0	4	0	4	0	3	0	3	3	3	0	6	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:121260261G>T	uc003eee.3	-	3	538	c.409C>A	c.(409-411)CGG>AGG	p.R137R		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	137	Helicase ATP-binding.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		GCTTTCTTCCGCATTTCCAAA	0.353								DNA_polymerases_(catalytic_subunits)					47	176					1.00776e-21	1.33284e-21	1	0	T	121260261	T	T	121260261	2	4	285	1	0	0	0	0	0	0	0	1	12263	1086	38	3		3	POLQ	3	121260261	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	12924823	121260261	76762169	74	52929											
SEMA5B	54437	broad.mit.edu	37	chr3	122629074	122629074	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcttgggtagtaagtagtCgtgtacacattggtctgctg	7	13	15	6	1	1	0	0	0	1	0	2	0	1	0	0	3	2	6	0	3	4	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:122629074C>A	uc003efz.1	-	23	3676	c.3372G>T	c.(3370-3372)ACG>ACT	p.T1124T	SEMA5B_uc011bju.1_Silent_p.T1030T|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003efy.1_Silent_p.T102T	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	1124	Cytoplasmic (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		AGTAAGTAGTCGTGTACACAT	0.547													12	54					1.36491e-13	1.65923e-13	1	0	A	122629074	A	A	122629074	2	1	285	1	0	0	0	0	0	0	0	1	14103	871	31	3		3	SEMA5B	3	122629074	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1368813	122629074	75393356	75	52930											
KALRN	8997	broad.mit.edu	37	chr3	124048750	124048750	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcaagatgtgcagtgaaGgtggtctgccatccgagatg	9	9	16	7	1	1	3	0	1	1	2	2	4	2	3	2	3	3	2	2	3	2	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:124048750G>A	uc003ehg.2	+	8	1448	c.1321G>A	c.(1321-1323)GGT>AGT	p.G441S	KALRN_uc010hrv.1_Missense_Mutation_p.G441S|KALRN_uc003ehf.1_Missense_Mutation_p.G441S|KALRN_uc011bjy.1_Missense_Mutation_p.G441S	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	441					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GTGCAGTGAAGGTGGTCTGCC	0.577													34	32					0	0	0	0	A	124048750	A	A	124048750	3	1	285	1	0	0	0	0	1	0	0	0	8014	1000	35	4	1351	4	KALRN	3	124048750	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1419676	124048750	73973680	76	52931											
PLXNA1	5361	broad.mit.edu	37	chr3	126739087	126739087	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccacgagctgaccaatgAcctggacggtgccggcatcc	9	6	11	15	3	0	2	0	2	0	0	2	4	2	3	5	3	2	2	5	3	1	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:126739087A>T	uc003ejg.2	+	20	3873	c.3869A>T	c.(3868-3870)GAC>GTC	p.D1290V		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1313	Potential.|Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CTGACCAATGACCTGGACGGT	0.627													20	37					0	0	0	0	T	126739087	T	T	126739087	3	4	285	1	0	0	0	0	1	0	0	0	12174	275	10	5	4016	5	PLXNA1	3	126739087	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	2690337	126739087	71283343	77	52932											
GATA2	2624	broad.mit.edu	37	chr3	128202703	128202703	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacctgtgcccgctcctacCagtcttcgcttgggcttgat	4	12	9	16	2	1	1	0	1	1	0	3	1	2	1	5	1	2	3	5	1	1	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:128202703C>T	uc003ekm.3	-	5	1452	c.1017G>A	c.(1015-1017)CTG>CTA	p.L339L	GATA2_uc003ekn.3_Silent_p.L339L|GATA2_uc003eko.2_Silent_p.L339L	NM_001145661	NP_001139133	P23769	GATA2_HUMAN	GATA binding protein 2 isoform 1	339					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(13)|lung(1)|skin(1)	15				GBM - Glioblastoma multiforme(114;0.173)		CCGCTCCTACCAGTCTTCGCT	0.602			Mis		AML(CML blast transformation)								3	49					0	0	0	0	T	128202703	T	T	128202703	2	4	285	1	0	0	0	0	0	0	0	1	6289	608	21	4		4	GATA2	3	128202703	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1463616	128202703	69819727	78	52933											
PIK3R4	30849	broad.mit.edu	37	chr3	130405134	130405134	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatcatgctttaaagtccaCgcattgcttgaagacctaag	14	11	7	9	1	1	2	1	1	0	1	2	2	2	2	2	0	2	3	2	0	5	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:130405134C>T	uc003enj.2	-	15	3977	c.3396G>A	c.(3394-3396)GCG>GCA	p.A1132A		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	1132	WD 3.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TTAAAGTCCACGCATTGCTTG	0.473													26	45					0	0	0	0	T	130405134	T	T	130405134	2	4	285	1	0	0	0	0	0	0	0	1	11976	523	19	1		1	PIK3R4	3	130405134	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2202431	130405134	67617296	79	52934											
PRR23B	389151	broad.mit.edu	37	chr3	138738793	138738793	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacctggactccccacgcaCggagagggaggtagaggttg	9	5	17	10	2	0	2	0	0	0	2	1	6	1	5	3	6	0	3	3	6	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:138738793C>A	uc003esy.1	-	1	976	c.711G>T	c.(709-711)CCG>CCT	p.P237P		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	237	Pro-rich.									breast(1)	1						TCCCCACGCACGGAGAGGGAG	0.662													14	18					7.93312e-07	8.68407e-07	1	0	A	138738793	A	A	138738793	2	1	285	1	0	0	0	0	0	0	0	1	12657	523	19	3		3	PRR23B	3	138738793	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	8333659	138738793	59283637	80	52935											
ZIC1	7545	broad.mit.edu	37	chr3	147128846	147128846	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tggcaaggtcttcgcgcgctCcgagaatttaaagatccaca	11	9	10	11	4	1	2	0	0	1	2	4	3	3	2	2	2	0	2	2	2	4	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:147128846C>G	uc003ewe.2	+	1	1666	c.947C>G	c.(946-948)TCC>TGC	p.S316C		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	316	C2H2-type 3.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TTCGCGCGCTCCGAGAATTTA	0.552													30	31					0	0	0	0	G	147128846	G	G	147128846	3	3	285	1	0	0	0	0	1	0	0	0	17745	855	30	2	949	2	ZIC1	3	147128846	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	8390053	147128846	50893584	81	52936											
AGTR1	185	broad.mit.edu	37	chr3	148459210	148459210	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcattgatcgatacctggctAttgttcacccaatgaagtcc	10	12	8	11	1	1	2	1	2	0	0	3	3	2	2	3	1	1	3	3	1	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:148459210A>T	uc003ewg.2	+	4	834	c.388A>T	c.(388-390)ATT>TTT	p.I130F	AGTR1_uc003ewh.2_Missense_Mutation_p.I130F|AGTR1_uc003ewi.2_Missense_Mutation_p.I130F|AGTR1_uc003ewj.2_Missense_Mutation_p.I130F|AGTR1_uc003ewk.2_Missense_Mutation_p.I130F	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	130	Cytoplasmic (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	ATACCTGGCTATTGTTCACCC	0.498													64	225					0	0	0	0	T	148459210	T	T	148459210	3	4	285	1	0	0	0	0	1	0	0	0	401	449	16	5	390	5	AGTR1	3	148459210	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	1330364	148459210	49563220	82	52937											
MME	4311	broad.mit.edu	37	chr3	154860118	154860118	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtccagaaatgctttccgcaAggtgaagaaaaaatctctct	14	10	8	9	1	2	3	0	1	2	2	5	3	4	3	2	1	1	2	2	1	6	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:154860118A>T	uc010hvr.1	+	12	1398	c.1187A>T	c.(1186-1188)AAG>ATG	p.K396M	MME_uc003fab.1_Missense_Mutation_p.K396M|MME_uc003fac.1_Missense_Mutation_p.K396M|MME_uc003fad.1_Missense_Mutation_p.K396M|MME_uc003fae.1_Missense_Mutation_p.K396M	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	396	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GCTTTCCGCAAGGTGAAGAAA	0.388													10	107					0	0	0	0	T	154860118	T	T	154860118	3	4	285	1	0	0	0	0	1	0	0	0	9698	86	3	5	1229	5	MME	3	154860118	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	6400908	154860118	43162312	83	52938											
PLCH1	23007	broad.mit.edu	37	chr3	155200709	155200709	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgacatgtgggcagtagataCaatggtgtccccttggctgg	8	11	14	8	0	0	2	0	1	0	1	1	2	1	2	2	4	1	3	2	4	3	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:155200709C>A	uc011bok.1	-	23	3407	c.3130G>T	c.(3130-3132)GTA>TTA	p.V1044L	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.V1006L	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1044					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GCAGTAGATACAATGGTGTCC	0.453													38	160					7.53189e-24	1.014e-23	1	0	A	155200709	A	A	155200709	3	1	285	1	0	0	0	0	1	0	0	0	12092	478	17	4	1955	4	PLCH1	3	155200709	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	340591	155200709	42821721	84	52939											
C3orf33	285315	broad.mit.edu	37	chr3	155493562	155493562	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	accattctcagttattcggcGtaatcgtccacgtagtttaa	10	14	7	10	4	1	0	1	0	1	0	5	0	2	0	2	1	0	4	2	1	4	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:155493562G>A	uc003fal.1	-	4	391	c.121C>T	c.(121-123)CGC>TGC	p.R41C	C3orf33_uc003fam.1_Missense_Mutation_p.R84C	NM_173657	NP_775928	Q96NB5	Q96NB5_HUMAN	hypothetical protein LOC285315	41							hydrolase activity, acting on ester bonds|nucleic acid binding				0			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GTTATTCGGCGTAATCGTCCA	0.303													37	110					0	0	0	0	A	155493562	A	A	155493562	3	1	285	1	0	0	0	0	1	0	0	0	2233	1145	40	1	646	1	C3orf33	3	155493562	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	292853	155493562	42528868	85	52940											
TNIK	23043	broad.mit.edu	37	chr3	170819288	170819288	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcccatcatgggtctcgctCtctccatcttcctcctcttc	3	15	5	18	1	5	0	1	0	4	0	12	0	9	0	4	1	0	1	4	1	0	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:170819288C>T	uc003fhh.2	-	22	2886	c.2541G>A	c.(2539-2541)GAG>GAA	p.E847E	TNIK_uc003fhi.2_Silent_p.E792E|TNIK_uc003fhj.2_Silent_p.E818E|TNIK_uc003fhk.2_Silent_p.E839E|TNIK_uc003fhl.2_Silent_p.E763E|TNIK_uc003fhm.2_Silent_p.E784E|TNIK_uc003fhn.2_Silent_p.E810E|TNIK_uc003fho.2_Silent_p.E755E|TNIK_uc003fhg.2_Silent_p.E25E	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	847	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGGTCTCGCTCTCTCCATCTT	0.498													145	544					0	0	0	0	T	170819288	T	T	170819288	2	4	285	1	0	0	0	0	0	0	0	1	16379	912	32	2		2	TNIK	3	170819288	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	15325726	170819288	27203142	86	52941											
GHSR	2693	broad.mit.edu	37	chr3	172163255	172163255	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgaaggcaaacaccactacaGctaaaaggacaatgggagag	18	4	11	8	0	0	2	0	1	0	1	0	4	0	3	1	3	3	2	1	3	6	2	rs147508651		TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:172163255G>C	uc003fib.1	-	2	797	c.797C>G	c.(796-798)GCT>GGT	p.A266G		NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	266	Helical; Name=6; (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CACCACTACAGCTAAAAGGAC	0.428													15	24					0	0	0	0	C	172163255	C	C	172163255	3	2	285	1	0	0	0	0	1	0	0	0	6412	985	34	4	307	4	GHSR	3	172163255	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1343967	172163255	25859175	87	52942											
MFN1	55669	broad.mit.edu	37	chr3	179103449	179103449	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaactcatgattacattagtAacaggattggcgtccgttac	12	12	9	8	2	1	1	1	1	0	0	2	3	2	2	1	2	4	2	1	2	5	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:179103449A>T	uc003fjs.2	+	15	1881	c.1755A>T	c.(1753-1755)GTA>GTT	p.V585V	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Silent_p.V613V|MFN1_uc010hxc.2_Silent_p.V327V	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	585	Helical; Name=1; (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TTACATTAGTAACAGGATTGG	0.403													33	120					0	0	0	0	T	179103449	T	T	179103449	2	4	285	1	0	0	0	0	0	0	0	1	9576	349	13	5		5	MFN1	3	179103449	Silent	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	6940194	179103449	18918981	88	52943											
LAMP3	27074	broad.mit.edu	37	chr3	182841990	182841990	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacaattgtgtagtcagacGagcactcatccactaagaga	14	8	9	10	1	2	2	2	0	0	2	3	4	3	2	1	0	1	3	1	0	3	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr3:182841990G>T	uc003flh.3	-	6	1354	c.1130C>A	c.(1129-1131)TCG>TAG	p.S377*		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	377	Lumenal (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			GTAGTCAGACGAGCACTCATC	0.383													16	129					2.48551e-13	3.00526e-13	1	0	T	182841990	T	T	182841990	4	4	285	1	0	0	0	0	0	1	0	0	8659	1059	37	3	124	3	LAMP3	3	182841990	Nonsense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	3738541	182841990	15180440	89	52944											
GAK	2580	broad.mit.edu	37	chr4	845576	845576	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccccgctcctcccgcgccCcgatcacactgaagttcgag	6	6	8	21	5	1	1	1	1	0	0	4	3	3	1	7	0	0	2	7	0	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:845576C>A	uc003gbm.3	-	25	3669	c.3470G>T	c.(3469-3471)GGG>GTG	p.G1157V	GAK_uc003gbn.3_Missense_Mutation_p.G1078V|GAK_uc003gbk.3_5'UTR|GAK_uc010ibi.2_Missense_Mutation_p.G382V|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.G1010V	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1157					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		CTCCCGCGCCCCGATCACACT	0.647													28	23					8.58068e-18	1.09319e-17	1	0	A	845576	A	A	845576	3	1	285	1	0	0	0	0	1	0	0	0	6230	623	22	4	481	4	GAK	4	845576	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		845576	190308700	90	52945											
TEC	7006	broad.mit.edu	37	chr4	48152891	48152891	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attactcaccctccaaacttGgtataaagggagactgtgta	13	11	8	9	0	1	1	1	0	0	1	2	2	2	1	2	2	2	2	2	2	6	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:48152891G>C	uc003gxz.2	-	10	952	c.861C>G	c.(859-861)ACC>ACG	p.T287T		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	287	SH2.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						CTCCAAACTTGGTATAAAGGG	0.313													27	126					0	0	0	0	C	48152891	C	C	48152891	2	2	285	1	0	0	0	0	0	0	0	1	15808	1335	47	4		4	TEC	4	48152891	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	47307315	48152891	143001385	91	52946											
FRYL	285527	broad.mit.edu	37	chr4	48512142	48512142	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcaactccaaaacaccaaaCttgagtgtttccagcaaacc	15	8	5	13	0	0	1	0	1	0	0	2	1	2	1	4	0	6	3	4	0	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:48512142C>G	uc003gyh.1	-	59	8933	c.8328G>C	c.(8326-8328)AAG>AAC	p.K2776N	FRYL_uc003gyf.1_Missense_Mutation_p.K172N|FRYL_uc003gyg.1_Missense_Mutation_p.K1472N	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2776					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AAACACCAAACTTGAGTGTTT	0.408													19	62					0	0	0	0	G	48512142	G	G	48512142	3	3	285	1	0	0	0	0	1	0	0	0	6098	564	20	4	737	4	FRYL	4	48512142	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	359251	48512142	142642134	92	52947											
LRRC66	339977	broad.mit.edu	37	chr4	52861265	52861265	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcttcctcagcccttgccccGgacagccttggctgctgtat	4	11	10	16	1	1	0	1	0	0	0	2	1	2	1	5	2	4	4	5	2	1	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:52861265G>A	uc003gzi.2	-	4	1936	c.1923C>T	c.(1921-1923)TCC>TCT	p.S641S		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	641						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CCCTTGCCCCGGACAGCCTTG	0.527													3	44					0	0	0	0	A	52861265	A	A	52861265	2	1	285	1	0	0	0	0	0	0	0	1	9068	1103	39	1		1	LRRC66	4	52861265	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4349123	52861265	138293011	93	52948											
UGT2B15	7366	broad.mit.edu	37	chr4	69519769	69519769	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcacacagggtcattaatGactgacttcaatgcattgag	13	11	8	9	0	3	3	3	3	0	0	3	3	3	3	0	1	1	1	0	1	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:69519769G>T	uc011cal.1	-	5	1337	c.1299C>A	c.(1297-1299)GTC>GTA	p.V433V		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	433					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						GGTCATTAATGACTGACTTCA	0.383													5	107					2.0095e-06	2.17857e-06	1	0	T	69519769	T	T	69519769	2	4	285	1	0	0	0	0	0	0	0	1	17026	1277	45	2		2	UGT2B15	4	69519769	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	16658504	69519769	121634507	94	52949											
UGT2B11	10720	broad.mit.edu	37	chr4	70080094	70080094	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatgtcatataattcccacAggatttcttgttcttgtgaa	11	17	6	7	0	3	1	1	1	2	0	4	2	4	2	1	1	0	1	1	1	4	8			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:70080094A>C	uc003heh.2	-	1	356	c.347T>G	c.(346-348)CTG>CGG	p.L116R	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	116					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						TAATTCCCACAGGATTTCTTG	0.294													17	52					0	0	0	0	C	70080094	C	C	70080094	3	2	285	1	0	0	0	0	1	0	0	0	17025	188	7	5	1266	5	UGT2B11	4	70080094	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	560325	70080094	121074182	95	52950											
SMR3A	26952	broad.mit.edu	37	chr4	71232543	71232543	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccagggagaatcccaccatcCcctcctccaccctatggtcc	8	7	6	20	0	0	1	0	0	0	1	5	2	5	1	9	2	0	0	9	2	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:71232543C>A	uc003hfg.1	+	3	318	c.237C>A	c.(235-237)TCC>TCA	p.S79S	SMR3B_uc011cas.1_Intron	NM_012390	NP_036522	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3	79	Pro-rich.|Poly-Pro.					extracellular region					0		all_hematologic(202;0.196)				TCCCACCATCCCCTCCTCCAC	0.552													42	68					8.68246e-10	1.00148e-09	1	0	A	71232543	A	A	71232543	2	1	285	1	0	0	0	0	0	0	0	1	14875	610	22	4		4	SMR3A	4	71232543	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1152449	71232543	119921733	96	52951											
COL25A1	84570	broad.mit.edu	37	chr4	109738585	109738585	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccaggcatgggtaagccatCtggcccctgttttaaagaga	10	9	12	10	0	1	1	0	0	1	1	1	2	1	1	4	3	1	3	4	3	3	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:109738585C>T	uc003hze.1	-	36	2461	c.1930G>A	c.(1930-1932)GAT>AAT	p.D644N	COL25A1_uc003hzd.2_RNA	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	644	Extracellular (Potential).					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		GGTAAGCCATCTGGCCCCTGT	0.388													18	35					0	0	0	0	T	109738585	T	T	109738585	3	4	285	1	0	0	0	0	1	0	0	0	3699	913	32	2	42	2	COL25A1	4	109738585	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	38506042	109738585	81415691	97	52952											
ANK2	287	broad.mit.edu	37	chr4	114274404	114274404	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgaaggctgctgaggaaGagccaggagagccttttgaa	11	8	16	6	0	0	5	0	3	0	2	0	7	0	6	2	4	3	2	2	4	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:114274404G>C	uc003ibe.3	+	38	4730	c.4630G>C	c.(4630-4632)GAG>CAG	p.E1544Q	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.E1559Q	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1511					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGCTGAGGAAGAGCCAGGAGA	0.433													13	47					0	0	0	0	C	114274404	C	C	114274404	3	2	285	1	0	0	0	0	1	0	0	0	621	943	33	2	4845	2	ANK2	4	114274404	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4535819	114274404	76879872	98	52953											
CCNA2	890	broad.mit.edu	37	chr4	122744744	122744744	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctagcagcgccgagcccgCctcgcgggtcgcaggccccg	4	4	15	18	7	0	0	0	0	0	0	2	1	0	0	5	2	4	3	5	2	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:122744744C>T	uc003iec.3	-	1	345	c.40G>A	c.(40-42)GCG>ACG	p.A14T		NM_001237	NP_001228	P20248	CCNA2_HUMAN	cyclin A	14					cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			ovary(1)	1						GCCGAGCCCGCCTCGCGGGTC	0.687													3	4					0	0	0	0	T	122744744	T	T	122744744	3	4	285	1	0	0	0	0	1	0	0	0	2925	739	26	4	1290	4	CCNA2	4	122744744	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	8470340	122744744	68409532	99	52954											
INPP4B	8821	broad.mit.edu	37	chr4	143045799	143045799	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcagacactggggcaagctgTacgcaagttcctgaaggagc	11	7	13	10	1	1	2	1	1	0	1	2	3	2	3	1	3	3	5	1	3	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:143045799T>G	uc003iix.3	-	20	2430	c.1835A>C	c.(1834-1836)TAC>TCC	p.Y612S	INPP4B_uc003iiw.3_Missense_Mutation_p.Y612S|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Missense_Mutation_p.Y427S|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Missense_Mutation_p.Y483S	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	612					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					GGGCAAGCTGTACGCAAGTTC	0.502													15	34					0	0	0	0	G	143045799	G	G	143045799	3	3	285	1	0	0	0	0	1	0	0	0	7792	1638	57	5	971	5	INPP4B	4	143045799	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	20301055	143045799	48108477	100	52955											
POU4F2	5458	broad.mit.edu	37	chr4	147561662	147561662	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctcacactgtcccacaataAtatgatcgcgctcaaaccca	13	8	4	16	2	2	1	2	1	0	0	4	1	3	1	3	0	1	1	3	0	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:147561662A>G	uc003ikv.2	+	2	1180	c.932A>G	c.(931-933)AAT>AGT	p.N311S		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	311	POU-specific.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					TCCCACAATAATATGATCGCG	0.607													6	21					0	0	0	0	G	147561662	G	G	147561662	3	3	285	1	0	0	0	0	1	0	0	0	12334	101	4	5	938	5	POU4F2	4	147561662	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	4515863	147561662	43592614	101	52956											
MAB21L2	10586	broad.mit.edu	37	chr4	151504404	151504404	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcatttcgcccaccgaatttGaggtggtgctctacctaaac	9	12	8	12	2	2	1	1	1	1	0	3	2	2	1	3	2	3	1	3	2	4	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:151504404G>A	uc003ilw.2	+	1	1328	c.223G>A	c.(223-225)GAG>AAG	p.E75K	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	75					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		CACCGAATTTGAGGTGGTGCT	0.607													9	19					0	0	0	0	A	151504404	A	A	151504404	3	1	285	1	0	0	0	0	1	0	0	0	9193	1291	45	2	225	2	MAB21L2	4	151504404	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	3942742	151504404	39649872	102	52957											
DCHS2	54798	broad.mit.edu	37	chr4	155253699	155253699	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taatagctgtccattctttcCagagtccatgtcaatagctg	10	14	7	10	0	2	1	1	0	1	1	5	1	5	1	3	0	2	2	3	0	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:155253699C>A	uc003inw.2	-	9	2164	c.2164G>T	c.(2164-2166)GGA>TGA	p.G722*	DCHS2_uc003inx.2_Nonsense_Mutation_p.G1221*	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	722	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCATTCTTTCCAGAGTCCATG	0.398													11	57					1.08611e-07	1.20058e-07	1	0	A	155253699	A	A	155253699	4	1	285	1	0	0	0	0	0	1	0	0	4305	603	21	4	6750	4	DCHS2	4	155253699	Nonsense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	3749295	155253699	35900577	103	52958											
GUCY1B3	2983	broad.mit.edu	37	chr4	156717623	156717623	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caagggtcaaatgatctactTacctgaagcagatagcatac	15	9	8	9	0	2	3	1	2	1	1	2	3	2	3	1	1	5	2	1	1	7	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:156717623T>A	uc003ipc.2	+	8	1105	c.938T>A	c.(937-939)TTA>TAA	p.L313*	GUCY1B3_uc011cio.1_Nonsense_Mutation_p.L335*|GUCY1B3_uc011cip.1_Nonsense_Mutation_p.L293*|GUCY1B3_uc003ipd.2_Nonsense_Mutation_p.L241*|GUCY1B3_uc010iqf.2_Nonsense_Mutation_p.L313*|GUCY1B3_uc010iqg.2_Nonsense_Mutation_p.L241*|GUCY1B3_uc011ciq.1_Nonsense_Mutation_p.L241*	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	313					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		ATGATCTACTTACCTGAAGCA	0.373													11	25					0	0	0	0	A	156717623	A	A	156717623	4	1	285	1	0	0	0	0	0	1	0	0	6934	1764	61	5	968	5	GUCY1B3	4	156717623	Nonsense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	1463924	156717623	34436653	104	52959											
DDX60	55601	broad.mit.edu	37	chr4	169138107	169138107	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactttgtttaacttttcccAaaaagttgtactcagttgtt	10	18	6	7	0	1	0	1	0	0	0	2	1	2	0	1	0	2	5	1	0	4	9			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:169138107A>C	uc003irp.2	-	38	5408	c.5116T>G	c.(5116-5118)TGG>GGG	p.W1706G	DDX60_uc003iro.2_3'UTR	NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1706							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AACTTTTCCCAAAAAGTTGTA	0.338													16	34					0	0	0	0	C	169138107	C	C	169138107	3	2	285	1	0	0	0	0	1	0	0	0	4395	130	5	5	26	5	DDX60	4	169138107	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	12420484	169138107	22016169	105	52960											
DDX60L	91351	broad.mit.edu	37	chr4	169369891	169369891	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagattccagcatccaaaaaCgtttaagttgcttaaaatga	16	11	6	8	1	0	2	0	1	0	1	2	2	2	2	2	0	3	4	2	0	5	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:169369891C>A	uc003irq.3	-	9	1257	c.1036G>T	c.(1036-1038)GTT>TTT	p.V346F	DDX60L_uc003irr.1_Missense_Mutation_p.V346F|DDX60L_uc003irs.1_Missense_Mutation_p.V73F	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	346							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CATCCAAAAACGTTTAAGTTG	0.303													9	24					1.58986e-06	1.72778e-06	1	0	A	169369891	A	A	169369891	3	1	285	1	0	0	0	0	1	0	0	0	4396	536	19	3	4204	3	DDX60L	4	169369891	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	231784	169369891	21784385	106	52961											
FAT1	2195	broad.mit.edu	37	chr4	187534263	187534263	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagcattcccgggagatacCtgcgtcggcatctgtggcct	7	9	13	12	3	1	2	0	0	1	2	3	3	2	2	3	3	3	2	3	3	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:187534263C>T	uc003izf.2	-	13	9651	c.9463G>A	c.(9463-9465)GGA>AGA	p.G3155R		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3155	Extracellular (Potential).|Cadherin 29.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CGGGAGATACCTGCGTCGGCA	0.567										HNSCC(5;0.00058)			4	11					0	0	0	0	T	187534263	T	T	187534263	3	4	285	1	0	0	0	0	1	0	0	0	5721	695	24	4	4363	4	FAT1	4	187534263	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	18164372	187534263	3620013	107	52962											
FAT1	2195	broad.mit.edu	37	chr4	187542674	187542675	+	Frame_Shift_Ins	INS	-	CC	CC																															tgattgactatgggctgtaaINSccatcccaacgaaactccca																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:187542674_187542675insCC	uc003izf.2	-	10	5253_5254	c.5065_5066insGG	c.(5065-5067)GTTfs	p.V1689fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1689	Extracellular (Potential).|Cadherin 15.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATGGGCTGTAACCATCCCAACG	0.386										HNSCC(5;0.00058)			---	---	---								CC	187542675	CC	CC	187542674	7	5	285	1	0	1	1	0	0	0	0	0	5721	43	2	0	8772	0	FAT1	4	187542674	Frame_Shift_Ins	INS	-	TCGA-DQ-5629-01A-01D-1870-08	8411	187542674	3611602	108	52963											
TRIML1	339976	broad.mit.edu	37	chr4	189060960	189060960	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	catcgccaggcagctccggtCccaggtgctgcagagcgagg	7	5	15	14	3	0	1	0	0	0	1	3	2	2	1	3	4	4	4	3	4	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr4:189060960C>A	uc003izm.1	+	1	363	c.248C>A	c.(247-249)TCC>TAC	p.S83Y		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	83					multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CAGCTCCGGTCCCAGGTGCTG	0.637													7	26					0.000157383	0.000165069	1	0	A	189060960	A	A	189060960	3	1	285	1	0	0	0	0	1	0	0	0	16617	855	30	2	250	2	TRIML1	4	189060960	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1518286	189060960	2093316	109	52964											
ADAMTS16	170690	broad.mit.edu	37	chr5	5146383	5146383	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcggctgaaaggctccaggCacgacttccacatggatctg	9	9	11	12	2	1	1	0	1	1	0	4	3	3	2	2	4	0	3	2	4	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:5146383C>A	uc003jdl.2	+	3	454	c.316C>A	c.(316-318)CAC>AAC	p.H106N	ADAMTS16_uc003jdk.1_Missense_Mutation_p.H106N|ADAMTS16_uc003jdj.1_Missense_Mutation_p.H106N	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	106					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						AGGCTCCAGGCACGACTTCCA	0.542													54	28					4.73848e-44	6.69923e-44	1	0	A	5146383	A	A	5146383	3	1	285	1	0	0	0	0	1	0	0	0	261	710	25	4	326	4	ADAMTS16	5	5146383	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		5146383	175768877	110	52965											
ADCY2	108	broad.mit.edu	37	chr5	7698397	7698397	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aattaaaattttaggagactGctactactgtgtatctggac	13	14	8	6	0	1	1	0	0	1	1	1	3	1	2	0	2	3	2	0	2	7	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:7698397G>A	uc003jdz.1	+	7	1086	c.1019G>A	c.(1018-1020)TGC>TAC	p.C340Y	ADCY2_uc011cmo.1_Missense_Mutation_p.C160Y	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	340	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TTAGGAGACTGCTACTACTGT	0.393													39	162					0	0	0	0	A	7698397	A	A	7698397	3	1	285	1	0	0	0	0	1	0	0	0	294	1319	46	4	1045	4	ADCY2	5	7698397	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2552014	7698397	173216863	111	52966											
CTNND2	1501	broad.mit.edu	37	chr5	11411728	11411728	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggagtccaccagctcgagaCctgttgtaagctcatcttcg	9	10	10	12	2	2	1	1	0	1	1	5	3	3	2	3	1	2	4	3	1	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:11411728C>G	uc003jfa.1	-	5	504	c.359G>C	c.(358-360)GGT>GCT	p.G120A	CTNND2_uc010itt.2_Missense_Mutation_p.G29A|CTNND2_uc011cmy.1_Missense_Mutation_p.G29A|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	120					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CAGCTCGAGACCTGTTGTAAG	0.368													51	29					0	0	0	0	G	11411728	G	G	11411728	3	3	285	1	0	0	0	0	1	0	0	0	4037	507	18	4	3390	4	CTNND2	5	11411728	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	3713331	11411728	169503532	112	52967											
DNAH5	1767	broad.mit.edu	37	chr5	13900483	13900483	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgcctggagccttcacCaataatgaagcctcaagacc	11	8	8	14	0	2	2	2	1	0	1	2	3	2	3	6	1	3	0	6	1	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:13900483C>T	uc003jfd.2	-	15	2133	c.2091G>A	c.(2089-2091)TTG>TTA	p.L697L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	697	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GAGCCTTCACCAATAATGAAG	0.408									Kartagener_syndrome				7	60					0	0	0	0	T	13900483	T	T	13900483	2	4	285	1	0	0	0	0	0	0	0	1	4626	593	21	4		4	DNAH5	5	13900483	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2488755	13900483	167014777	113	52968											
RASA1	5921	broad.mit.edu	37	chr5	86675667	86675667	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttcagaaatacttccacCgtaagtggtgaaattttcat	12	13	8	8	1	2	2	2	1	0	1	3	2	3	2	2	2	1	2	2	2	4	6	rs138785106	by1000genomes	TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:86675667C>T	uc003kiw.2	+	19	2721	c.2603C>T	c.(2602-2604)CCG>CTG	p.P868L	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.P691L|RASA1_uc011ctv.1_Missense_Mutation_p.P701L|RASA1_uc011ctw.1_Missense_Mutation_p.P702L|RASA1_uc010jaw.2_Missense_Mutation_p.P690L	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	868	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		ATACTTCCACCGTAAGTGGTG	0.303													9	13					0	0	0	0	T	86675667	T	T	86675667	3	4	285	1	0	0	0	0	1	0	0	0	13125	666	23	1	2689	1	RASA1	5	86675667	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	72775184	86675667	94239593	114	52969											
PAM	5066	broad.mit.edu	37	chr5	102343267	102343267	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcagaccgggaaaatggtcgGatccagtgttttaaaactga	13	9	12	7	2	0	2	0	1	0	1	2	4	1	4	2	3	1	2	2	3	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:102343267G>T	uc003knw.2	+	19	2494	c.2121G>T	c.(2119-2121)CGG>CGT	p.R707R	PAM_uc003kns.2_Silent_p.R600R|PAM_uc003knt.2_Silent_p.R707R|PAM_uc003knu.2_Silent_p.R707R|PAM_uc003knv.2_Silent_p.R707R|PAM_uc011cuz.1_Silent_p.R610R|PAM_uc003knz.2_5'UTR	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	707	Peptidyl-alpha-hydroxyglycine alpha- amidating lyase (By similarity).|NHL 4.|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	AAAATGGTCGGATCCAGTGTT	0.433													21	56					4.35082e-09	4.90555e-09	1	0	T	102343267	T	T	102343267	2	4	285	1	0	0	0	0	0	0	0	1	11466	1161	41	2		2	PAM	5	102343267	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	15667600	102343267	78571993	115	52970											
WDR36	134430	broad.mit.edu	37	chr5	110448824	110448824	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtgctgcgatggattgctctAttaggacttgggaccttcct	6	14	12	9	1	1	0	0	0	1	0	2	4	2	3	2	3	3	2	2	3	2	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:110448824A>G	uc003kpd.2	+	16	2053	c.1936A>G	c.(1936-1938)ATT>GTT	p.I646V	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	646	WD 8.				response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GGATTGCTCTATTAGGACTTG	0.289													19	45					0	0	0	0	G	110448824	G	G	110448824	3	3	285	1	0	0	0	0	1	0	0	0	17358	449	16	5	1998	5	WDR36	5	110448824	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	8105557	110448824	70466436	116	52971											
DMXL1	1657	broad.mit.edu	37	chr5	118485227	118485227	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtaggaatggactgtgaaatGcatgtgtattgccaatggca	12	11	13	5	0	0	1	0	1	0	0	0	3	0	3	1	3	2	4	1	3	5	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:118485227G>C	uc003ksd.2	+	18	3886	c.3705G>C	c.(3703-3705)ATG>ATC	p.M1235I	DMXL1_uc010jcl.1_Missense_Mutation_p.M1235I	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1235	WD 10.									ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		ACTGTGAAATGCATGTGTATT	0.433													21	55					0	0	0	0	C	118485227	C	C	118485227	3	2	285	1	0	0	0	0	1	0	0	0	4616	1319	46	4	3775	4	DMXL1	5	118485227	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	8036403	118485227	62430033	117	52972											
ZNF608	57507	broad.mit.edu	37	chr5	123982854	123982855	+	Missense_Mutation	DNP	CC	AA	AA																															gccataataaagtgactgagCcagggcaggatgtctttgtg																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:123982854_123982855CC>AA	uc003ktq.1	-	4	3345_3346	c.3222_3223GG>TT	c.(3220-3225)CTGGCT>CTTTCT	p.A1075S	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.A1075S|ZNF608_uc003ktt.1_Missense_Mutation_p.A1075S|ZNF608_uc003ktp.1_5'Flank	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1075						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		AGTGACTGAGCCAGGGCAGGAT	0.48													10	31					0	0	0	0	AA	123982855	AA	AA	123982854	3	1	285	1	0	0	0	0	1	0	0	0	18101	739	26	4	1339	4	ZNF608	5	123982854	Missense_Mutation	DNP	CC	TCGA-DQ-5629-01A-01D-1870-08	5497627	123982854	56932406	118	52973											
SLC27A6	28965	broad.mit.edu	37	chr5	128351610	128351610	+	Frame_Shift_Del	DEL	G	-	-																															aaggatcataaggtgcgtttGgcaattggaaatggcatacg																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:128351610delG	uc003kuy.2	+	6	1398	c.1002delG	c.(1000-1002)TTGfs	p.L334fs	SLC27A6_uc003kuz.2_Frame_Shift_Del_p.L334fs	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	334					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGGTGCGTTTGGCAATTGGAA	0.328													---	---	---								-	128351610	-	-	128351610	7	5	285	1	0	1	0	1	0	0	0	0	14594	1339	47	0	1020	0	SLC27A6	5	128351610	Frame_Shift_Del	DEL	G	TCGA-DQ-5629-01A-01D-1870-08	4368756	128351610	52563650	119	52974											
ADAMTS19	171019	broad.mit.edu	37	chr5	129001220	129001221	+	Frame_Shift_Ins	INS	-	A	A																															aagtgctggtgatacctgctINSggagcaagaagaatcaaagt																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:129001220_129001221insA	uc003kvb.1	+	16	2436_2437	c.2436_2437insA	c.(2434-2439)GCTGGAfs	p.A812fs	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	812_813	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TGATACCTGCTGGAGCAAGAAG	0.406													---	---	---								A	129001221	A	A	129001220	7	5	285	1	0	1	1	0	0	0	0	0	264	1567	55	0	2498	0	ADAMTS19	5	129001220	Frame_Shift_Ins	INS	-	TCGA-DQ-5629-01A-01D-1870-08	649610	129001220	51914040	120	52975											
MATR3	9782	broad.mit.edu	37	chr5	138654693	138654693	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggcaagccagtgagagttCatttatcccagaagtataaa	14	11	9	7	0	1	2	1	1	0	2	2	3	2	2	2	1	1	3	2	1	6	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:138654693C>T	uc003ldu.2	+	11	1832	c.1405C>T	c.(1405-1407)CAT>TAT	p.H469Y	MATR3_uc010jfb.2_Missense_Mutation_p.H469Y|MATR3_uc003ldt.2_Missense_Mutation_p.H131Y|MATR3_uc003ldw.2_Missense_Mutation_p.H469Y|MATR3_uc003ldx.2_Missense_Mutation_p.H469Y|MATR3_uc010jfc.2_Missense_Mutation_p.H469Y|MATR3_uc003ldy.2_Missense_Mutation_p.H146Y|MATR3_uc011czb.1_Missense_Mutation_p.H181Y|MATR3_uc003ldz.2_Missense_Mutation_p.H469Y|MATR3_uc003lea.2_Missense_Mutation_p.H469Y|MATR3_uc003leb.2_Missense_Mutation_p.H131Y|MATR3_uc003lec.2_Missense_Mutation_p.H146Y	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	469	RRM 1.					nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AGTGAGAGTTCATTTATCCCA	0.348													9	23					0	0	0	0	T	138654693	T	T	138654693	3	4	285	1	0	0	0	0	1	0	0	0	9390	826	29	2	1431	2	MATR3	5	138654693	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	9653473	138654693	42260567	121	52976											
PCDHGA1	56114	broad.mit.edu	37	chr5	140712201	140712201	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtggccgtccaggaccacggCcagcccccgctctccgccac	5	4	11	21	4	1	0	0	0	1	0	3	1	2	1	8	3	1	1	8	3	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:140712201C>A	uc003lji.1	+	1	1950	c.1950C>A	c.(1948-1950)GGC>GGA	p.G650G	PCDHGA1_uc011dan.1_Silent_p.G650G	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	650	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGACCACGGCCAGCCCCCGC	0.706													16	27					1.99824e-07	2.20343e-07	1	0	A	140712201	A	A	140712201	2	1	285	1	0	0	0	0	0	0	0	1	11604	726	26	4		4	PCDHGA1	5	140712201	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2057508	140712201	40203059	122	52977											
PCDHGB3	56102	broad.mit.edu	37	chr5	140751806	140751806	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgcaggccagcgagcccggGctgttcagcctgggcctgcg	4	6	17	14	3	1	0	1	0	0	0	1	1	1	0	4	3	5	3	4	3	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:140751806G>T	uc003ljw.1	+	1	1845	c.1845G>T	c.(1843-1845)GGG>GGT	p.G615G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Silent_p.G615G|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	615	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGCCCGGGCTGTTCAGCC	0.687													22	48					5.26018e-13	6.34316e-13	1	0	T	140751806	T	T	140751806	2	4	285	1	0	0	0	0	0	0	0	1	11618	1190	42	4		4	PCDHGB3	5	140751806	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	39605	140751806	40163454	123	52978											
PCDHGA6	56109	broad.mit.edu	37	chr5	140755543	140755543	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gaggtgcgcacggcgcgcgcCctgctggacagagacgcgct	6	4	17	14	7	0	1	0	0	0	1	0	4	0	2	1	3	2	3	1	3	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:140755543C>G	uc003ljy.1	+	1	1893	c.1893C>G	c.(1891-1893)GCC>GCG	p.A631A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.A631A	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	631	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGCGCGCGCCCTGCTGGACA	0.701													17	34					0	0	0	0	G	140755543	G	G	140755543	2	3	285	1	0	0	0	0	0	0	0	1	11612	610	22	4		4	PCDHGA6	5	140755543	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	3737	140755543	40159717	124	52979											
PCDHGA7	56108	broad.mit.edu	37	chr5	140764014	140764014	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacactggagtcctgtacgcGctgcaatcctttgattatga	9	12	10	10	2	0	2	0	2	0	0	2	4	2	3	2	1	2	3	2	1	3	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:140764014G>C	uc003lka.1	+	1	1548	c.1548G>C	c.(1546-1548)GCG>GCC	p.A516A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Silent_p.A516A	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	516	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTGTACGCGCTGCAATCCT	0.517													9	21					0	0	0	0	C	140764014	C	C	140764014	2	2	285	1	0	0	0	0	0	0	0	1	11613	1074	38	3		3	PCDHGA7	5	140764014	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	8471	140764014	40151246	125	52980											
PCDHGB4	8641	broad.mit.edu	37	chr5	140768373	140768373	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttaaatacattagattttGaagaagtcaaagaatattcc	17	15	5	4	0	1	4	1	1	0	3	2	4	2	4	1	0	1	0	1	0	9	8			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:140768373G>C	uc003lkc.1	+	1	922	c.922G>C	c.(922-924)GAA>CAA	p.E308Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.E308Q	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	308	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTAGATTTTGAAGAAGTCAA	0.398													7	20					0	0	0	0	C	140768373	C	C	140768373	3	2	285	1	0	0	0	0	1	0	0	0	11619	1291	45	2	924	2	PCDHGB4	5	140768373	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4359	140768373	40146887	126	52981											
RBM27	54439	broad.mit.edu	37	chr5	145648991	145648992	+	Frame_Shift_Ins	INS	-	T	T																															ttatttcgtagatgttaataINStccaagttagaaaaaaacaa																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:145648991_145648992insT	uc003lnz.3	+	17	2701_2702	c.2535_2536insT	c.(2533-2538)ATATCCfs	p.I845fs	RBM27_uc003lny.2_Frame_Shift_Ins_p.I790fs	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	845_846	Potential.				mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGATGTTAATATCCAAGTTAGA	0.243													---	---	---								T	145648992	T	T	145648991	7	5	285	1	0	1	1	0	0	0	0	0	13192	439	16	0	2601	0	RBM27	5	145648991	Frame_Shift_Ins	INS	-	TCGA-DQ-5629-01A-01D-1870-08	4880618	145648991	35266269	127	52982											
POU4F3	5459	broad.mit.edu	37	chr5	145719943	145719943	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccttaaaaagaacgtggTgagagtctggttctgcaacc	12	9	12	8	1	2	2	0	1	2	2	2	4	2	3	2	3	3	2	2	3	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:145719943T>C	uc003loa.2	+	2	1042	c.953T>C	c.(952-954)GTG>GCG	p.V318A		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	318	Homeobox.				sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGAACGTGGTGAGAGTCTGG	0.547													9	27					0	0	0	0	C	145719943	C	C	145719943	3	2	285	1	0	0	0	0	1	0	0	0	12335	1696	59	5	959	5	POU4F3	5	145719943	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	70952	145719943	35195317	128	52983											
GABRG2	2566	broad.mit.edu	37	chr5	161576255	161576255	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgctctggtggagtatggcaCcttgcattattttgtcagca	7	15	11	8	0	2	0	1	0	1	0	2	1	2	1	1	3	3	5	1	3	2	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:161576255C>A	uc003lyz.3	+	8	1422	c.1064C>A	c.(1063-1065)ACC>AAC	p.T355N	GABRG2_uc010jjc.2_Missense_Mutation_p.T395N|GABRG2_uc003lyy.3_Missense_Mutation_p.T355N|GABRG2_uc011dej.1_Missense_Mutation_p.T260N	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	355	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GAGTATGGCACCTTGCATTAT	0.423													12	43					1.49906e-05	1.60588e-05	1	0	A	161576255	A	A	161576255	3	1	285	1	0	0	0	0	1	0	0	0	6206	507	18	4	1218	4	GABRG2	5	161576255	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	15856312	161576255	19339005	129	52984											
WWC1	23286	broad.mit.edu	37	chr5	167891755	167891755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttcctcggtcaagtcgctgCgctccgagcgtctgatccgt	4	11	11	15	6	2	1	1	1	1	0	7	2	5	1	3	1	2	2	3	1	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:167891755C>T	uc003lzu.2	+	21	3031	c.2938C>T	c.(2938-2940)CGC>TGC	p.R980C	WWC1_uc003lzv.2_Missense_Mutation_p.R986C|WWC1_uc011den.1_Missense_Mutation_p.R986C|WWC1_uc003lzw.2_Missense_Mutation_p.R779C|WWC1_uc010jjf.1_Missense_Mutation_p.R252C	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	980	Interaction with PRKCZ.|Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CAAGTCGCTGCGCTCCGAGCG	0.597													7	24					0	0	0	0	T	167891755	T	T	167891755	3	4	285	1	0	0	0	0	1	0	0	0	17479	768	27	1	3038	1	WWC1	5	167891755	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	6315500	167891755	13023505	130	52985											
SLIT3	6586	broad.mit.edu	37	chr5	168671713	168671713	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctgtactgtacttacagtcGctctagctgcttcaggtcct	6	14	9	12	1	2	0	1	0	1	0	4	0	3	0	1	1	5	6	1	1	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:168671713G>T	uc003mab.2	-	3	757	c.337C>A	c.(337-339)CGA>AGA	p.R113R	SLIT3_uc010jjg.2_Silent_p.R113R|SLIT3_uc010jji.2_Silent_p.R113R	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	113	LRR 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTTACAGTCGCTCTAGCTGC	0.393													10	22					9.70103e-10	1.11327e-09	1	0	T	168671713	T	T	168671713	2	4	285	1	0	0	0	0	0	0	0	1	14805	1095	38	3		3	SLIT3	5	168671713	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	779958	168671713	12243547	131	52986											
NPM1	4869	broad.mit.edu	37	chr5	170818333	170818333	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtttaggggctggtgcaaagGatgagttgcacattgttgaa	10	12	15	4	0	0	2	0	2	0	0	0	3	0	3	0	4	2	6	0	4	3	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:170818333G>A	uc011dex.1	+	4	298	c.163G>A	c.(163-165)GAT>AAT	p.D55N	NPM1_uc003mbh.2_Missense_Mutation_p.D55N|NPM1_uc003mbi.2_Missense_Mutation_p.D55N|NPM1_uc003mbj.2_Missense_Mutation_p.D55N	NM_002520	NP_002511	P06748	NPM_HUMAN	nucleophosmin 1 isoform 1	55	Necessary for interaction with APEX1.|Required for interaction with SENP3.				anti-apoptosis|cell aging|CenH3-containing nucleosome assembly at centromere|centrosome cycle|DNA repair|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	histone binding|NF-kappaB binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|RNA binding|Tat protein binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	haematopoietic_and_lymphoid_tissue(3109)|skin(1)	3110	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGTGCAAAGGATGAGTTGCA	0.398			T|F 	ALK|RARA|MLF1	NHL|APL|AML								21	29					0	0	0	0	A	170818333	A	A	170818333	3	1	285	1	0	0	0	0	1	0	0	0	10641	1174	41	2	173	2	NPM1	5	170818333	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2146620	170818333	10096927	132	52987											
UIMC1	51720	broad.mit.edu	37	chr5	176396024	176396024	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgctaccctggacagctttGagaaaagcagaacccctccc	11	6	8	16	1	0	2	0	1	0	2	1	4	1	3	5	1	4	3	5	1	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:176396024G>A	uc011dfp.1	-	6	899	c.732C>T	c.(730-732)CTC>CTT	p.L244L	UIMC1_uc003mfc.1_Silent_p.L121L|UIMC1_uc003mfd.1_Intron|UIMC1_uc003mfg.1_Intron|UIMC1_uc003mff.1_Intron	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	244					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGACAGCTTTGAGAAAAGCAG	0.517													14	68					0	0	0	0	A	176396024	A	A	176396024	2	1	285	1	0	0	0	0	0	0	0	1	17039	1277	45	2		2	UIMC1	5	176396024	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	5577691	176396024	4519236	133	52988											
FLT4	2324	broad.mit.edu	37	chr5	180053207	180053207	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtgctggcctctgtcacctCcttgagcaccagggcatgtg	5	11	12	13	0	2	1	1	1	1	0	3	1	3	1	4	2	2	3	4	2	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr5:180053207C>T	uc003mma.3	-	9	1241	c.1162G>A	c.(1162-1164)GAG>AAG	p.E388K	FLT4_uc003mlz.3_Missense_Mutation_p.E388K|FLT4_uc003mmb.1_5'UTR|FLT4_uc011dgy.1_Missense_Mutation_p.E388K	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	388	Ig-like C2-type 4.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCTGTCACCTCCTTGAGCACC	0.627									Congenital_Hereditary_Lymphedema				14	46					0	0	0	0	T	180053207	T	T	180053207	3	4	285	1	0	0	0	0	1	0	0	0	5976	864	30	2	3025	2	FLT4	5	180053207	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	3657183	180053207	862053	134	52989											
SLC17A3	10786	broad.mit.edu	37	chr6	25851036	25851036	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttttctgaggtgcttatcCatggataggaaacggggtca	9	13	12	7	1	2	1	1	1	1	0	3	3	3	3	1	5	2	1	1	5	3	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:25851036C>T	uc003nfi.3	-	6	658	c.548G>A	c.(547-549)TGG>TAG	p.W183*	SLC17A3_uc003nfk.3_Nonsense_Mutation_p.W261*|SLC17A3_uc011djz.1_Nonsense_Mutation_p.W261*|SLC17A3_uc011dka.1_Nonsense_Mutation_p.W183*	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	183					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						GGTGCTTATCCATGGATAGGA	0.413													13	37					0	0	0	0	T	25851036	T	T	25851036	4	4	285	1	0	0	0	0	0	1	0	0	14483	595	21	4	738	4	SLC17A3	6	25851036	Nonsense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		25851036	145264031	135	52990											
HIST1H1T	3010	broad.mit.edu	37	chr6	26108148	26108148	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaccaaagacatacctacTcgttcctgtgacactgaaag	14	8	7	12	1	0	3	0	2	0	1	2	3	1	3	3	0	3	2	3	0	5	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:26108148T>A	uc003ngj.2	-	1	217	c.174A>T	c.(172-174)CGA>CGT	p.R58R		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	58	H15.				cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						ACATACCTACTCGTTCCTGTG	0.532													24	56					0	0	0	0	A	26108148	A	A	26108148	2	1	285	1	0	0	0	0	0	0	0	1	7166	1538	54	5		5	HIST1H1T	6	26108148	Silent	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	257112	26108148	145006919	136	52991											
HIST1H2AG	8969	broad.mit.edu	37	chr6	27101036	27101036	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctggagtacctgaccgccgaGatcctggaactggcgggcaa	9	6	14	12	3	0	2	0	1	0	1	1	5	1	4	4	4	2	2	4	4	3	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:27101036G>A	uc003niw.2	+	1	220	c.186G>A	c.(184-186)GAG>GAA	p.E62E	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	62					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						TGACCGCCGAGATCCTGGAAC	0.667													24	44					0	0	0	0	A	27101036	A	A	27101036	2	1	285	1	0	0	0	0	0	0	0	1	7172	933	33	2		2	HIST1H2AG	6	27101036	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	992888	27101036	144014031	137	52992											
COL11A2	1302	broad.mit.edu	37	chr6	33145004	33145004	+	Splice_Site	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctggggcccgggaagacccTacatacagggaaagagaagt	13	4	14	10	1	0	2	0	0	0	2	0	5	0	4	3	4	2	0	3	4	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:33145004T>A	uc003ocx.1	-	24	2200	c.1972_splice	c.e24-1	p.G658_splice	COL11A2_uc010jul.1_Splice_Site_p.R37_splice|COL11A2_uc003ocy.1_Splice_Site_p.G572_splice|COL11A2_uc003ocz.1_Splice_Site_p.G551_splice	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1						cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GGGAAGACCCTACATACAGGG	0.547													26	38					0	0	0	0	A	33145004	A	A	33145004	5	1	285	1	0	0	0	0	0	0	1	0	3683	1536	53	5	3412	5	COL11A2	6	33145004	Splice_Site	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	6043968	33145004	137970063	138	52993											
DAAM2	23500	broad.mit.edu	37	chr6	39843198	39843198	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgagcggggtgtggaccctGacctggctcccttggagaac	7	8	15	11	1	0	3	0	2	0	1	1	5	1	4	3	5	2	1	3	5	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:39843198G>T	uc003oow.2	+	11	1411	c.1255G>T	c.(1255-1257)GAC>TAC	p.D419Y	DAAM2_uc010jxc.2_Missense_Mutation_p.D419Y|DAAM2_uc003oox.2_Missense_Mutation_p.D419Y	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	419					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					TGTGGACCCTGACCTGGCTCC	0.572													24	40					5.35356e-11	6.27131e-11	1	0	T	39843198	T	T	39843198	3	4	285	1	0	0	0	0	1	0	0	0	4233	1290	45	2	1293	2	DAAM2	6	39843198	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	6698194	39843198	131271869	139	52994											
C6orf142	90523	broad.mit.edu	37	chr6	54025221	54025221	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggacaacacattagaaccAccagtggaggtaataacttc	17	7	8	9	0	0	1	0	0	0	1	1	3	0	3	2	3	3	1	2	3	6	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:54025221A>T	uc003pcg.3	+	5	854	c.741A>T	c.(739-741)CCA>CCT	p.P247P	C6orf142_uc003pcf.2_Silent_p.P771P|C6orf142_uc003pch.3_Intron|C6orf142_uc011dxa.1_Silent_p.P782P	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	247						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					CATTAGAACCACCAGTGGAGG	0.398													6	22					0	0	0	0	T	54025221	T	T	54025221	2	4	285	1	0	0	0	0	0	0	0	1	2343	146	6	5		5	C6orf142	6	54025221	Silent	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	14182023	54025221	117089846	140	52995											
GFRAL	389400	broad.mit.edu	37	chr6	55223861	55223861	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccttcaagtgcaatgtaccTgtaggaccattacacaaagt	13	11	7	10	0	1	0	1	0	0	0	2	1	2	1	3	1	3	3	3	1	6	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:55223861T>A	uc003pcm.1	+	6	963	c.877T>A	c.(877-879)TGT>AGT	p.C293S		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	293	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GCAATGTACCTGTAGGACCAT	0.393													31	63					0	0	0	0	A	55223861	A	A	55223861	3	1	285	1	0	0	0	0	1	0	0	0	6388	1580	55	5	899	5	GFRAL	6	55223861	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	1198640	55223861	115891206	141	52996											
COL21A1	81578	broad.mit.edu	37	chr6	55939064	55939064	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ttccaggctggcctggtgagCcattgcttcccattaaaccc	7	11	9	14	0	0	1	0	1	0	0	2	1	2	1	5	3	3	2	5	3	2	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:55939064C>A	uc003pcs.2	-	20	2163	c.1931G>T	c.(1930-1932)GGC>GTC	p.G644V	COL21A1_uc010jzz.2_Missense_Mutation_p.G29V|COL21A1_uc011dxg.1_Missense_Mutation_p.G29V|COL21A1_uc011dxh.1_Missense_Mutation_p.G29V|COL21A1_uc003pcr.2_Missense_Mutation_p.A2S	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	644	Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GCCTGGTGAGCCATTGCTTCC	0.328													37	60					5.71845e-15	7.02731e-15	1	0	A	55939064	A	A	55939064	3	1	285	1	0	0	0	0	1	0	0	0	3695	739	26	4	986	4	COL21A1	6	55939064	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	715203	55939064	115176003	142	52997											
DST	667	broad.mit.edu	37	chr6	56357099	56357099	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgaaccactttttcccatcGactttgtacactgataagta	11	15	5	10	1	0	2	0	2	0	0	2	3	1	2	2	0	2	2	2	0	4	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:56357099G>A	uc003pdf.2	-	79	14354	c.14326C>T	c.(14326-14328)CGA>TGA	p.R4776*	DST_uc003pcz.3_Nonsense_Mutation_p.R4598*|DST_uc011dxj.1_Nonsense_Mutation_p.R4627*|DST_uc011dxk.1_Nonsense_Mutation_p.R4638*|DST_uc003pcy.3_Nonsense_Mutation_p.R4272*|DST_uc003pda.3_5'UTR	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6684	Spectrin 17.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTTCCCATCGACTTTGTACA	0.383													18	72					0	0	0	0	A	56357099	A	A	56357099	4	1	285	1	0	0	0	0	0	1	0	0	4805	1066	37	1	2777	1	DST	6	56357099	Nonsense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	418035	56357099	114757968	143	52998											
BAI3	577	broad.mit.edu	37	chr6	69703783	69703783	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcgatcttctgatgtctGtggagatcctgagaaatgtg	9	12	13	7	1	3	3	0	2	3	2	4	6	4	3	1	2	0	0	1	2	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:69703783G>T	uc003pev.3	+	11	2306	c.1858G>T	c.(1858-1860)GTG>TTG	p.V620L	BAI3_uc010kak.2_Missense_Mutation_p.V620L	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	620	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TCTGATGTCTGTGGAGATCCT	0.463													53	70					1.86277e-20	2.4351e-20	1	0	T	69703783	T	T	69703783	3	4	285	1	0	0	0	0	1	0	0	0	1302	1377	48	4	1892	4	BAI3	6	69703783	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	13346684	69703783	101411284	144	52999											
COL12A1	1303	broad.mit.edu	37	chr6	75806969	75806969	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagacacatttagttcttacCggcggccctggtgggcccct	6	10	12	13	2	1	1	0	0	1	1	1	2	1	1	4	4	1	1	4	4	2	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:75806969C>T	uc003phs.2	-	59	8743	c.8577G>A	c.(8575-8577)CCG>CCA	p.P2859P	COL12A1_uc003pht.2_Silent_p.P1695P	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2859	Triple-helical region (COL2) with 1 imperfection.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TAGTTCTTACCGGCGGCCCTG	0.483													17	46					0	0	0	0	T	75806969	T	T	75806969	2	4	285	1	0	0	0	0	0	0	0	1	3684	666	23	1		1	COL12A1	6	75806969	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	6103186	75806969	95308098	145	53000											
RARS2	57038	broad.mit.edu	37	chr6	88229969	88229969	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaatgctttttttgtcctttAtctgtcttgggaagaaaata	11	18	7	5	0	2	1	0	0	2	1	3	2	3	2	1	1	1	1	1	1	6	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:88229969A>T	uc003pme.2	-	13	1101	c.1041T>A	c.(1039-1041)GAT>GAA	p.D347E	RARS2_uc003pmb.2_Missense_Mutation_p.D172E|RARS2_uc003pmc.2_Missense_Mutation_p.D172E|RARS2_uc003pmd.2_5'UTR|RARS2_uc003pmf.2_RNA	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	347					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		TTTGTCCTTTATCTGTCTTGG	0.313													48	86					0	0	0	0	T	88229969	T	T	88229969	3	4	285	1	0	0	0	0	1	0	0	0	13124	446	16	5	727	5	RARS2	6	88229969	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	12423000	88229969	82885098	146	53001											
SFRS18	25957	broad.mit.edu	37	chr6	99850546	99850546	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagatcctctgtcactcctCtcatcttcactgtctcctga	6	15	4	16	0	7	2	4	1	4	1	11	2	9	2	3	0	0	0	3	0	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:99850546C>T	uc003ppo.3	-	11	1425	c.1197G>A	c.(1195-1197)GAG>GAA	p.E399E	SFRS18_uc003ppl.2_5'Flank|SFRS18_uc003ppp.3_Silent_p.E399E|SFRS18_uc011eag.1_Silent_p.E399E	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	399						nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)		TGTCACTCCTCTCATCTTCAC	0.398													59	130					0	0	0	0	T	99850546	T	T	99850546	2	4	285	1	0	0	0	0	0	0	0	1	14239	912	32	2		2	SFRS18	6	99850546	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	11620577	99850546	71264521	147	53002											
SLC22A16	85413	broad.mit.edu	37	chr6	110746270	110746270	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	taacactccactcaggagggCcatagtcccaacaaacaact	15	6	6	14	0	1	0	1	0	0	0	3	1	3	1	3	2	4	0	3	2	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:110746270C>T	uc003puf.2	-	8	1607	c.1540G>A	c.(1540-1542)GCC>ACC	p.A514T	SLC22A16_uc003pue.2_Missense_Mutation_p.A495T	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	514	Helical; (Potential).				acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CTCAGGAGGGCCATAGTCCCA	0.423													30	49					0	0	0	0	T	110746270	T	T	110746270	3	4	285	1	0	0	0	0	1	0	0	0	14512	739	26	4	197	4	SLC22A16	6	110746270	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	10895724	110746270	60368797	148	53003											
RFPL4B	442247	broad.mit.edu	37	chr6	112671163	112671163	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccgacttgagcaaagtctgCacgtgagggaggagctccgg	9	6	16	10	3	1	2	0	2	1	0	2	5	2	4	2	3	3	3	2	3	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:112671163C>A	uc003pvx.1	+	3	565	c.253C>A	c.(253-255)CAC>AAC	p.H85N		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	85	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		GCAAAGTCTGCACGTGAGGGA	0.537													13	19					2.31682e-05	2.47018e-05	1	0	A	112671163	A	A	112671163	3	1	285	1	0	0	0	0	1	0	0	0	13321	710	25	4	255	4	RFPL4B	6	112671163	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1924893	112671163	58443904	149	53004											
HS3ST5	222537	broad.mit.edu	37	chr6	114378425	114378425	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgtatgacatattattttagGgccagttcaatgtcctccca	10	15	7	9	0	1	1	1	1	0	0	3	1	3	1	3	1	0	2	3	1	5	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:114378425G>C	uc003pwg.3	-	2	1069	c.1037C>G	c.(1036-1038)CCC>CGC	p.P346R	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.P346R	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	346	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		ATTATTTTAGGGCCAGTTCAA	0.398													17	44					0	0	0	0	C	114378425	C	C	114378425	3	2	285	1	0	0	0	0	1	0	0	0	7407	1232	43	4	7	4	HS3ST5	6	114378425	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1707262	114378425	56736642	150	53005											
C6orf204	387119	broad.mit.edu	37	chr6	118887220	118887220	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccctggccacagttatccggGgcagtgagtttggataaaga	10	9	13	9	1	0	2	0	1	0	1	1	3	1	3	3	4	0	3	3	4	3	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:118887220G>C	uc003pxz.1	-	3	1080	c.492C>G	c.(490-492)GCC>GCG	p.A164A	C6orf204_uc003pya.1_Silent_p.A167A|C6orf204_uc003pyb.2_Silent_p.A164A|C6orf204_uc011ebj.1_Silent_p.A62A|C6orf204_uc003pyc.2_Silent_p.A167A|C6orf204_uc011ebl.1_Silent_p.A62A	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	164						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		AGTTATCCGGGGCAGTGAGTT	0.498													29	50					0	0	0	0	C	118887220	C	C	118887220	2	2	285	1	0	0	0	0	0	0	0	1	2363	1219	43	4		4	C6orf204	6	118887220	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4508795	118887220	52227847	151	53006											
TRDN	10345	broad.mit.edu	37	chr6	123759228	123759228	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttttttttccacatcaatgGcagtttccttctcacttttc	6	20	3	12	0	2	0	2	0	1	0	6	0	4	0	2	1	0	2	2	1	1	8			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:123759228G>C	uc003pzj.1	-	12	1053	c.1031C>G	c.(1030-1032)GCC>GGC	p.A344G	TRDN_uc003pzk.1_Missense_Mutation_p.A345G|TRDN_uc003pzl.1_Missense_Mutation_p.A345G|uc003pzm.1_5'Flank	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	344	Lumenal.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		CACATCAATGGCAGTTTCCTT	0.348													4	11					0	0	0	0	C	123759228	C	C	123759228	3	2	285	1	0	0	0	0	1	0	0	0	16535	1203	42	4	1278	4	TRDN	6	123759228	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4872008	123759228	47355839	152	53007											
TCF21	6943	broad.mit.edu	37	chr6	134210906	134210906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctggacacgctcaggctggCgtccagctacatcgcccact	7	7	11	16	3	1	0	1	0	0	0	3	1	2	1	2	3	2	4	2	3	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:134210906C>T	uc003qei.3	+	1	647	c.371C>T	c.(370-372)GCG>GTG	p.A124V	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Missense_Mutation_p.A124V	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	124	Helix-loop-helix motif.				branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		CTCAGGCTGGCGTCCAGCTAC	0.617													17	63					0	0	0	0	T	134210906	T	T	134210906	3	4	285	1	0	0	0	0	1	0	0	0	15757	768	27	1	373	1	TCF21	6	134210906	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	10451678	134210906	36904161	153	53008											
AHI1	54806	broad.mit.edu	37	chr6	135679271	135679271	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tagcaacagactgtcttaccGttggtgctgtatctacctga	9	13	9	10	1	2	2	0	1	2	1	2	2	2	2	2	1	5	4	2	1	5	5	rs73559947	by1000genomes	TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:135679271G>T	uc003qgi.2	-	24	3548	c.3164C>A	c.(3163-3165)ACG>AAG	p.T1055K	AHI1_uc003qgf.2_RNA|AHI1_uc003qgg.2_Missense_Mutation_p.T505K|AHI1_uc003qgh.2_Missense_Mutation_p.T1055K|AHI1_uc003qgj.2_Missense_Mutation_p.T1055K|AHI1_uc003qgk.3_RNA	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	1055	SH3.					adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		CTGTCTTACCGTTGGTGCTGT	0.358													48	203					8.00217e-19	1.04005e-18	1	0	T	135679271	T	T	135679271	3	4	285	1	0	0	0	0	1	0	0	0	413	1159	40	3	450	3	AHI1	6	135679271	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1468365	135679271	35435796	154	53009											
REPS1	85021	broad.mit.edu	37	chr6	139229952	139229952	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caagtggtgttgtgcctttgCtctttaagacaagaattcca	10	14	9	8	0	1	2	0	0	1	2	2	2	2	2	2	1	2	2	2	1	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:139229952C>T	uc003qii.2	-	18	2648	c.2069G>A	c.(2068-2070)AGC>AAC	p.S690N	REPS1_uc003qig.3_Missense_Mutation_p.S663N|REPS1_uc011edr.1_Missense_Mutation_p.S689N|REPS1_uc003qij.2_Missense_Mutation_p.S599N|REPS1_uc003qik.2_Missense_Mutation_p.S296N	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	690	Interaction with RALBP1 (By similarity).					coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TGTGCCTTTGCTCTTTAAGAC	0.363													15	22					0	0	0	0	T	139229952	T	T	139229952	3	4	285	1	0	0	0	0	1	0	0	0	13293	811	28	4	333	4	REPS1	6	139229952	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	3550681	139229952	31885115	155	53010											
GRM1	2911	broad.mit.edu	37	chr6	146625871	146625871	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attatttcctgaaactgaggCtggacactaacacgaggaat	14	10	9	8	1	0	2	0	2	0	0	1	5	1	4	1	3	2	1	1	3	4	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:146625871C>A	uc010khw.1	+	4	1545	c.1075C>A	c.(1075-1077)CTG>ATG	p.L359M	GRM1_uc010khv.1_Missense_Mutation_p.L359M|GRM1_uc003qll.2_Missense_Mutation_p.L359M|GRM1_uc011edz.1_Missense_Mutation_p.L359M|GRM1_uc011eea.1_Missense_Mutation_p.L359M	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	359	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GAAACTGAGGCTGGACACTAA	0.493													17	33					1.67942e-08	1.87479e-08	1	0	A	146625871	A	A	146625871	3	1	285	1	0	0	0	0	1	0	0	0	6835	796	28	4	1085	4	GRM1	6	146625871	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	7395919	146625871	24489196	156	53011											
PLEKHG1	57480	broad.mit.edu	37	chr6	151153189	151153189	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagggtgtttatgatggctcGgcagtacagtcagaagatta	11	11	13	6	1	1	3	1	1	0	2	2	3	1	3	0	3	1	4	0	3	4	4	rs113595784		TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:151153189G>T	uc003qny.1	+	16	3254	c.2942G>T	c.(2941-2943)CGG>CTG	p.R981L	PLEKHG1_uc011eel.1_Missense_Mutation_p.R1021L|PLEKHG1_uc011eem.1_Missense_Mutation_p.R1040L|PLEKHG1_uc003qnz.2_Missense_Mutation_p.R981L	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	981					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		ATGATGGCTCGGCAGTACAGT	0.507													55	105					4.78724e-31	6.64322e-31	1	0	T	151153189	T	T	151153189	3	4	285	1	0	0	0	0	1	0	0	0	12123	1116	39	3	2996	3	PLEKHG1	6	151153189	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4527318	151153189	19961878	157	53012											
SYNE1	23345	broad.mit.edu	37	chr6	152786476	152786476	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccactgtattgccatagcGatcccagttagagatcactt	11	11	8	11	1	1	1	1	0	0	1	2	3	2	1	3	0	3	2	3	0	3	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:152786476G>T	uc010kiw.2	-	18	2451	c.1849C>A	c.(1849-1851)CGC>AGC	p.R617S	SYNE1_uc003qot.3_Missense_Mutation_p.R624S|SYNE1_uc003qou.3_Missense_Mutation_p.R617S|SYNE1_uc010kjb.1_Missense_Mutation_p.R600S|SYNE1_uc003qpa.1_Missense_Mutation_p.R617S|SYNE1_uc003qow.2_5'Flank|SYNE1_uc003qox.1_Missense_Mutation_p.R133S|SYNE1_uc003qoz.2_Missense_Mutation_p.R49S|SYNE1_uc003qoy.2_Missense_Mutation_p.R184S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	617	Cytoplasmic (Potential).|HAT 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTGCCATAGCGATCCCAGTTA	0.448										HNSCC(10;0.0054)			29	55					1.08312e-15	1.342e-15	1	0	T	152786476	T	T	152786476	3	4	285	1	0	0	0	0	1	0	0	0	15511	1058	37	3	25133	3	SYNE1	6	152786476	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1633287	152786476	18328591	158	53013											
T	6862	broad.mit.edu	37	chr6	166578115	166578115	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgggagtacccaggttgctgGctgtctccgggttcctccat	4	12	13	12	1	1	0	0	0	1	0	4	1	3	1	4	4	2	5	4	4	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:166578115G>A	uc003quu.1	-	6	1201	c.708C>T	c.(706-708)AGC>AGT	p.S236S	T_uc003qut.1_Silent_p.S236S|T_uc003quv.1_Silent_p.S236S	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	236					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		CAGGTTGCTGGCTGTCTCCGG	0.418									Chordoma_Familial_Clustering_of				29	58					0	0	0	0	A	166578115	A	A	166578115	2	1	285	1	0	0	0	0	0	0	0	1	15554	1194	42	4		4	T	6	166578115	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	13791639	166578115	4536952	159	53014											
RPS6KA2	6196	broad.mit.edu	37	chr6	167271702	167271702	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agttacttcttctgcagtgtCttctgtggtgggctccacat	5	16	10	10	0	4	0	0	0	4	0	5	0	5	0	1	2	2	3	1	2	1	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:167271702C>A	uc003qvd.1	-	2	222	c.109G>T	c.(109-111)GAC>TAC	p.D37Y	RPS6KA2_uc003qvc.1_Missense_Mutation_p.D37Y	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	Error:Variant_position_missing_in_Q15349_after_alignment					axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		TCTGCAGTGTCTTCTGTGGTG	0.443													10	41					3.62473e-10	4.20245e-10	1	0	A	167271702	A	A	167271702	3	1	285	1	0	0	0	0	1	0	0	0	13716	913	32	2	2303	2	RPS6KA2	6	167271702	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	693587	167271702	3843365	160	53015											
THBS2	7058	broad.mit.edu	37	chr6	169629677	169629677	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgctcctaccttctcatcgGtcacaccgtcattgtcatcg	6	13	6	16	3	4	0	4	0	1	0	8	0	5	0	3	1	2	1	3	1	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr6:169629677G>T	uc003qwt.2	-	15	2497	c.2249C>A	c.(2248-2250)ACC>AAC	p.T750N		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	750	TSP type-3 2.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CTTCTCATCGGTCACACCGTC	0.557													11	100					6.40141e-05	6.77708e-05	1	0	T	169629677	T	T	169629677	3	4	285	1	0	0	0	0	1	0	0	0	15920	1261	44	4	1305	4	THBS2	6	169629677	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2357975	169629677	1485390	161	53016											
AMZ1	155185	broad.mit.edu	37	chr7	2752343	2752343	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcgaccgctgggagatgtTcacgggccagctcccggcca	6	6	13	16	4	1	1	1	0	0	1	3	3	2	1	5	3	1	3	5	3	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:2752343T>C	uc003smr.1	+	7	1689	c.1328T>C	c.(1327-1329)TTC>TCC	p.F443S	AMZ1_uc003sms.1_3'UTR|AMZ1_uc011jwa.1_Missense_Mutation_p.F192S	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	443							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		TGGGAGATGTTCACGGGCCAG	0.687													13	34					0	0	0	0	C	2752343	C	C	2752343	3	2	285	1	0	0	0	0	1	0	0	0	596	1783	62	5	1350	5	AMZ1	7	2752343	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08		2752343	156386320	162	53017											
MIOS	54468	broad.mit.edu	37	chr7	7636045	7636045	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgaaaaccacttcctcgatGtgcgctttgtctcattaata	10	14	6	11	3	1	0	1	0	1	0	5	2	2	0	2	0	2	1	2	0	4	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:7636045G>A	uc003srf.2	+	11	2662	c.2354G>A	c.(2353-2355)TGT>TAT	p.C785Y	MIOS_uc003srg.2_Missense_Mutation_p.C320Y|MIOS_uc010ktq.2_Missense_Mutation_p.C180Y	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	785											0						CTTCCTCGATGTGCGCTTTGT	0.403													60	96					0	0	0	0	A	7636045	A	A	7636045	3	1	285	1	0	0	0	0	1	0	0	0	9642	1377	48	4	2384	4	MIOS	7	7636045	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4883702	7636045	151502618	163	53018											
ITGB8	3696	broad.mit.edu	37	chr7	20371492	20371492	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctgcaaaacgaccggcgAggtcccgcctcgttcctctg	6	8	11	16	5	1	0	0	0	1	0	4	2	3	0	5	2	3	2	5	2	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:20371492A>T	uc003suu.2	+	1	768	c.63A>T	c.(61-63)CGA>CGT	p.R21R	ITGB8_uc011jyh.1_Intron|ITGB8_uc003sut.2_Silent_p.R21R	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	21					cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						ACGACCGGCGAGGTCCCGCCT	0.433													23	44					0	0	0	0	T	20371492	T	T	20371492	2	4	285	1	0	0	0	0	0	0	0	1	7940	291	11	5		5	ITGB8	7	20371492	Silent	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	12735447	20371492	138767171	164	53019											
TRIL	9865	broad.mit.edu	37	chr7	28995715	28995715	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gggggtgtccccgcgcagctCgcgcagcgtggccgagtcgc	3	5	18	15	7	0	0	0	0	0	0	3	1	1	0	3	3	2	3	3	3	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:28995715C>G	uc003szt.2	-	3	2315	c.1948G>C	c.(1948-1950)GAG>CAG	p.E650Q		NM_014817	NP_055632	Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine rich repeats	650	Extracellular (Potential).				inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding				0						CCGCGCAGCTCGCGCAGCGTG	0.711													2	7					0	0	0	0	G	28995715	G	G	28995715	3	3	285	1	0	0	0	0	1	0	0	0	16552	893	31	3	491	3	TRIL	7	28995715	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	8624223	28995715	130142948	165	53020											
NOD1	10392	broad.mit.edu	37	chr7	30472736	30472736	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgctttaacgtctggttgActttcaacatttctgccaaa	11	15	6	9	1	3	1	1	1	2	0	3	1	3	1	1	1	4	2	1	1	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:30472736A>G	uc003tav.2	-	12	3204	c.2681T>C	c.(2680-2682)GTC>GCC	p.V894A		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	894					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						CGTCTGGTTGACTTTCAACAT	0.323													9	46					0	0	0	0	G	30472736	G	G	30472736	3	3	285	1	0	0	0	0	1	0	0	0	10570	275	10	5	192	5	NOD1	7	30472736	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	1477021	30472736	128665927	166	53021											
ADCYAP1R1	117	broad.mit.edu	37	chr7	31142969	31142969	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcgtgtttgagctggggctgGgctccttccaggtaggtgtg	3	13	17	8	1	0	1	0	1	0	0	3	1	2	1	2	5	1	5	2	5	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:31142969G>T	uc003tca.1	+	14	1388	c.1165G>T	c.(1165-1167)GGC>TGC	p.G389C	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.G368C|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.G417C|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.G417C|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.G416C|ADCYAP1R1_uc003tcf.1_Missense_Mutation_p.G147C	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	389	Helical; Name=7; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						GCTGGGGCTGGGCTCCTTCCA	0.547													13	67					4.3838e-07	4.81045e-07	1	0	T	31142969	T	T	31142969	3	4	285	1	0	0	0	0	1	0	0	0	303	1232	43	4	1215	4	ADCYAP1R1	7	31142969	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	670233	31142969	127995694	167	53022											
NEUROD6	63974	broad.mit.edu	37	chr7	31378227	31378227	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caagagtcccatgccctgggGgagtggtgagctcagggctg	7	7	17	10	0	1	2	1	1	0	1	2	3	2	3	2	4	2	2	2	4	1	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:31378227G>A	uc003tch.2	-	2	1009	c.656C>T	c.(655-657)CCC>CTC	p.P219L		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	219					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						ATGCCCTGGGGGAGTGGTGAG	0.527													26	54					0	0	0	0	A	31378227	A	A	31378227	3	1	285	1	0	0	0	0	1	0	0	0	10405	1232	43	4	361	4	NEUROD6	7	31378227	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	235258	31378227	127760436	168	53023											
ABCA13	154664	broad.mit.edu	37	chr7	48443311	48443311	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtggacttaactcagcatCagcacaaacagacccgagct	14	7	8	12	1	2	1	2	0	0	1	2	3	2	2	1	1	5	3	1	1	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:48443311C>T	uc003toq.2	+	39	11930	c.11905C>T	c.(11905-11907)CAG>TAG	p.Q3969*	ABCA13_uc010kys.1_Nonsense_Mutation_p.Q1043*|ABCA13_uc003tos.1_Nonsense_Mutation_p.Q795*|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3969	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AACTCAGCATCAGCACAAACA	0.478													24	18					0	0	0	0	T	48443311	T	T	48443311	4	4	285	1	0	0	0	0	0	1	0	0	31	827	29	2	11888	2	ABCA13	7	48443311	Nonsense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	17065084	48443311	110695352	169	53024											
ZNF735	730291	broad.mit.edu	37	chr7	63680469	63680469	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagacacataagataattcAtactggagagaaaccctaca	19	8	6	8	0	1	3	1	0	0	3	1	5	1	4	1	1	3	0	1	1	6	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:63680469A>G	uc011kdn.1	+	4	1040	c.1040A>G	c.(1039-1041)CAT>CGT	p.H347R		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	347	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGATAATTCATACTGGAGAG	0.408													18	31					0	0	0	0	G	63680469	G	G	63680469	3	3	285	1	0	0	0	0	1	0	0	0	18191	217	8	5	1054	5	ZNF735	7	63680469	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	15237158	63680469	95458194	170	53025											
MLXIPL	51085	broad.mit.edu	37	chr7	73010505	73010505	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggctgggctgggcactgAgtgtgctcacgagcccatga	7	8	16	10	1	1	3	1	3	0	0	1	4	1	3	1	3	2	4	1	3	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:73010505A>C	uc003tyn.1	-	13	2084	c.2036T>G	c.(2035-2037)CTC>CGC	p.L679R	MLXIPL_uc003tyj.1_Missense_Mutation_p.L58R|MLXIPL_uc003tyk.1_Missense_Mutation_p.L677R|MLXIPL_uc003tyl.1_Missense_Mutation_p.L677R|MLXIPL_uc003tym.1_Missense_Mutation_p.L679R|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.L585R	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	679					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				CTGGGCACTGAGTGTGCTCAC	0.627													12	55					0	0	0	0	C	73010505	C	C	73010505	3	2	285	1	0	0	0	0	1	0	0	0	9690	304	11	5	542	5	MLXIPL	7	73010505	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	9330036	73010505	86128158	171	53026											
CACNA2D1	781	broad.mit.edu	37	chr7	81579768	81579768	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtagaaactggattccaatGatataccacagggagggatt	15	9	11	6	0	0	2	0	1	0	1	1	5	1	5	2	3	2	1	2	3	5	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:81579768G>T	uc003uhr.1	-	39	3472	c.3216C>A	c.(3214-3216)ATC>ATA	p.I1072I	uc003uhq.1_5'Flank|CACNA2D1_uc011kgy.1_Silent_p.I284I	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	1084	Helical; (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GGATTCCAATGATATACCACA	0.388													33	78					6.04164e-23	8.0854e-23	1	0	T	81579768	T	T	81579768	2	4	285	1	0	0	0	0	0	0	0	1	2560	1280	45	2		2	CACNA2D1	7	81579768	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	8569263	81579768	77558895	172	53027											
PCLO	27445	broad.mit.edu	37	chr7	82785474	82785474	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggaaacagcacttaaagcGttaacctctgagaggaagcc	15	6	11	9	1	1	1	0	1	1	1	1	5	1	3	2	2	5	2	2	2	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:82785474G>C	uc003uhx.2	-	2	772	c.483C>G	c.(481-483)AAC>AAG	p.N161K	PCLO_uc003uhv.2_Missense_Mutation_p.N161K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	161					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CACTTAAAGCGTTAACCTCTG	0.403													32	73					0	0	0	0	C	82785474	C	C	82785474	3	2	285	1	0	0	0	0	1	0	0	0	11637	1136	40	3	15058	3	PCLO	7	82785474	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1205706	82785474	76353189	173	53028											
SAMD9	54809	broad.mit.edu	37	chr7	92732854	92732854	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gggagagagttgctgtattaCggcaatactgtctgggatcc	9	11	14	7	1	1	1	0	0	1	1	2	4	2	3	1	3	3	4	1	3	4	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:92732854C>T	uc003umf.2	-	3	2813	c.2557G>A	c.(2557-2559)GTA>ATA	p.V853I	SAMD9_uc003umg.2_Missense_Mutation_p.V853I	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	853						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TGCTGTATTACGGCAATACTG	0.333													24	93					0	0	0	0	T	92732854	T	T	92732854	3	4	285	1	0	0	0	0	1	0	0	0	13891	536	19	1	2216	1	SAMD9	7	92732854	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	9947380	92732854	66405809	174	53029											
DYNC1I1	1780	broad.mit.edu	37	chr7	95664996	95664996	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accggaatggctttcccaacGggagacgtcaataacttcgt	11	9	10	11	4	1	1	1	0	0	1	3	3	2	2	2	3	2	1	2	3	4	3	rs142103982		TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:95664996G>A	uc003uoc.3	+	13	1624	c.1347G>A	c.(1345-1347)ACG>ACA	p.T449T	DYNC1I1_uc003uod.3_Silent_p.T432T|DYNC1I1_uc003uob.2_Silent_p.T412T|DYNC1I1_uc003uoe.3_Silent_p.T429T|DYNC1I1_uc010lfl.2_Silent_p.T438T	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	449	WD 4.				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CTTTCCCAACGGGAGACGTCA	0.473													50	138					0	0	0	0	A	95664996	A	A	95664996	2	1	285	1	0	0	0	0	0	0	0	1	4864	1103	39	1		1	DYNC1I1	7	95664996	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2932142	95664996	63473667	175	53030											
MDFIC	29969	broad.mit.edu	37	chr7	114563068	114563068	+	Frame_Shift_Del	DEL	G	-	-																															ctaggcggcagcggcgcggcGcgggctcggcggagcggccc																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:114563068delG	uc003vhf.2	+	2	570	c.307delG	c.(307-309)GCGfs	p.A103fs	MDFIC_uc003vhg.2_RNA	NM_199072	NP_951038	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing protein	Error:Variant_position_missing_in_Q9P1T7_after_alignment					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleolus|nucleolus|nucleus	cyclin binding|Tat protein binding			ovary(1)	1						GCGGCGCGGCGCGGGCTCGGC	0.771													---	---	---								-	114563068	-	-	114563068	7	5	285	1	0	1	0	1	0	0	0	0	9458	1087	38	0	313	0	MDFIC	7	114563068	Frame_Shift_Del	DEL	G	TCGA-DQ-5629-01A-01D-1870-08	18898072	114563068	44575595	176	53031											
WNT2	7472	broad.mit.edu	37	chr7	116918348	116918348	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcatccgggtgacatgggagGtgtcgtagcctctcccacag	7	9	13	12	2	2	1	1	1	1	0	5	2	3	2	3	3	1	1	3	3	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:116918348G>T	uc003viz.2	-	5	1244	c.944C>A	c.(943-945)ACC>AAC	p.T315N	WNT2_uc003vja.2_Missense_Mutation_p.T219N	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	315					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		GACATGGGAGGTGTCGTAGCC	0.602													32	24					2.61193e-14	3.20104e-14	1	0	T	116918348	T	T	116918348	3	4	285	1	0	0	0	0	1	0	0	0	17454	1261	44	4	142	4	WNT2	7	116918348	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2355280	116918348	42220315	177	53032											
GPR37	2861	broad.mit.edu	37	chr7	124387352	124387352	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcacggaagcggtctaTgcacagagcacataaggtga	13	5	14	9	2	1	2	0	1	1	1	1	3	1	3	0	4	4	4	0	4	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:124387352T>A	uc003vli.2	-	2	1720	c.1069A>T	c.(1069-1071)ATA>TTA	p.I357L		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	357	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						AAGCGGTCTATGCACAGAGCA	0.493													13	66					0	0	0	0	A	124387352	A	A	124387352	3	1	285	1	0	0	0	0	1	0	0	0	6729	1464	51	5	776	5	GPR37	7	124387352	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	7469004	124387352	34751311	178	53033											
GRM8	2918	broad.mit.edu	37	chr7	126410105	126410105	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcataagatgaatcccgagCaattcgctccagccctgcaa	12	9	7	13	2	1	2	1	1	0	1	4	3	3	2	3	0	3	3	3	0	4	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:126410105C>G	uc003vlr.2	-	6	1482	c.1171G>C	c.(1171-1173)GCT>CCT	p.A391P	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.A391P|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.A112P	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	391	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GAATCCCGAGCAATTCGCTCC	0.388										HNSCC(24;0.065)			12	18					0	0	0	0	G	126410105	G	G	126410105	3	3	285	1	0	0	0	0	1	0	0	0	6842	710	25	4	1625	4	GRM8	7	126410105	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2022753	126410105	32728558	179	53034											
OR2A12	346525	broad.mit.edu	37	chr7	143792691	143792691	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccatattactcttattctgaGgctgcctttttgtggcccac	6	16	7	12	0	2	1	0	1	2	0	2	1	2	1	3	2	2	1	3	2	3	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:143792691G>T	uc011kty.1	+	1	491	c.491G>T	c.(490-492)AGG>ATG	p.R164M		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	164	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					CTTATTCTGAGGCTGCCTTTT	0.458													55	74					1.46357e-32	2.04356e-32	1	0	T	143792691	T	T	143792691	3	4	285	1	0	0	0	0	1	0	0	0	11029	1000	35	4	493	4	OR2A12	7	143792691	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	17382586	143792691	15345972	180	53035											
CNTNAP2	26047	broad.mit.edu	37	chr7	146536965	146536965	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcgacacagggagaaactGgaaaccctatcatcaagatg	16	5	10	10	1	2	2	2	0	0	2	2	5	2	3	1	2	3	0	1	2	4	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:146536965G>T	uc003weu.1	+	3	887	c.371G>T	c.(370-372)TGG>TTG	p.W124L		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	124	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GGGAGAAACTGGAAACCCTAT	0.443										HNSCC(39;0.1)			19	34					9.95505e-16	1.23684e-15	1	0	T	146536965	T	T	146536965	3	4	285	1	0	0	0	0	1	0	0	0	3662	1357	47	4	381	4	CNTNAP2	7	146536965	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2744274	146536965	12601698	181	53036											
CNTNAP2	26047	broad.mit.edu	37	chr7	147183129	147183129	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacagtggggccacctgccaCaactgtgagtgccaatttat	10	10	10	11	0	0	1	0	1	0	0	0	1	0	1	4	2	4	0	4	2	4	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:147183129C>A	uc003weu.1	+	11	2289	c.1773C>A	c.(1771-1773)CAC>CAA	p.H591Q		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	591	EGF-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCACCTGCCACAACTGTGAGT	0.458										HNSCC(39;0.1)			19	38					3.51602e-12	4.20616e-12	1	0	A	147183129	A	A	147183129	3	1	285	1	0	0	0	0	1	0	0	0	3662	477	17	4	1815	4	CNTNAP2	7	147183129	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	646164	147183129	11955534	182	53037											
CNTNAP2	26047	broad.mit.edu	37	chr7	147869371	147869371	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagggcttcctgggctgcatCcgctccttgaggatgaatgg	6	10	14	11	1	0	2	0	2	0	0	3	3	3	3	3	4	1	4	3	4	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:147869371C>A	uc003weu.1	+	18	3327	c.2811C>A	c.(2809-2811)ATC>ATA	p.I937I		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	937	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGGGCTGCATCCGCTCCTTGA	0.537										HNSCC(39;0.1)			23	49					1.64293e-13	1.99184e-13	1	0	A	147869371	A	A	147869371	2	1	285	1	0	0	0	0	0	0	0	1	3662	845	30	2		2	CNTNAP2	7	147869371	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	686242	147869371	11269292	183	53038											
SSPO	23145	broad.mit.edu	37	chr7	149474083	149474083	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggacttgttgcccaggctGggggggcgcccactgcactg	5	7	17	12	1	0	0	0	0	0	0	0	2	0	1	2	5	2	3	2	5	0	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:149474083G>T	uc010lpk.2	+	3	293	c.293G>T	c.(292-294)TGG>TTG	p.W98L	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	98	EMI.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGCCCAGGCTGGGGGGGCGCC	0.622													12	54					1.05317e-09	1.20553e-09	1	0	T	149474083	T	T	149474083	3	4	285	1	0	0	0	0	1	0	0	0	15255	1357	47	4	303	4	SSPO	7	149474083	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1604712	149474083	9664580	184	53039											
CRYGN	155051	broad.mit.edu	37	chr7	151133382	151133382	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgtgaagttgcaaccctcGaagatttctaggcggaaatg	11	9	11	10	3	1	2	0	1	1	1	2	4	1	3	2	2	2	2	2	2	5	3	rs113942095	by1000genomes	TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr7:151133382G>A	uc003wke.2	-	3	396	c.300C>T	c.(298-300)TTC>TTT	p.F100F	CRYGN_uc003wkf.2_Intron|CRYGN_uc003wkg.2_RNA|CRYGN_uc010lqd.1_RNA	NM_144727	NP_653328	Q8WXF5	CRGN_HUMAN	gammaN-crystallin	100	Beta/gamma crystallin 'Greek key' 3.										0			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCAACCCTCGAAGATTTCTA	0.537													11	24					0	0	0	0	A	151133382	A	A	151133382	2	1	285	1	0	0	0	0	0	0	0	1	3933	1049	37	1		1	CRYGN	7	151133382	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1659299	151133382	8005281	185	53040											
FAM160B2	64760	broad.mit.edu	37	chr8	21960044	21960044	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgattcccgctgtaggtgatCggggacttgatgcagagaat	9	11	14	7	2	0	4	0	3	0	1	2	6	1	5	1	3	1	3	1	3	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:21960044C>T	uc011kyx.1	+	16	2049	c.1998C>T	c.(1996-1998)ATC>ATT	p.I666I	FAM160B2_uc011kyy.1_RNA	NM_022749	NP_073586	Q86V87	F16B2_HUMAN	retinoic acid induced 16	666											0						TGTAGGTGATCGGGGACTTGA	0.617													2	0					0	0	0	0	T	21960044	T	T	21960044	2	4	285	1	0	0	0	0	0	0	0	1	5499	874	31	1		1	FAM160B2	8	21960044	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		21960044	124403978	186	53041											
TRIM35	23087	broad.mit.edu	37	chr8	27145527	27145527	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcccagcaggcagggcgccGaggagaagcgttccgggttc	8	4	17	12	4	0	1	0	0	0	1	2	3	1	1	3	4	3	4	3	4	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:27145527G>A	uc003xfl.1	-	6	1104	c.1022C>T	c.(1021-1023)TCG>TTG	p.S341L	TRIM35_uc010lup.1_3'UTR	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	341	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		GCAGGGCGCCGAGGAGAAGCG	0.682													8	47					0	0	0	0	A	27145527	A	A	27145527	3	1	285	1	0	0	0	0	1	0	0	0	16576	1059	37	1	463	1	TRIM35	8	27145527	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	5185483	27145527	119218495	187	53042											
CCDC25	55246	broad.mit.edu	37	chr8	27606107	27606107	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccacattaacgttgttcaTcttgcagcctgccaagagag	11	11	8	11	1	2	1	1	0	1	1	2	2	2	1	3	0	5	3	3	0	3	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:27606107T>C	uc003xgc.2	-	6	366	c.253A>G	c.(253-255)ATG>GTG	p.M85V	CCDC25_uc003xgd.2_Missense_Mutation_p.M17V|CCDC25_uc011lan.1_Intron|CCDC25_uc011lao.1_Intron|CCDC25_uc003xge.2_Intron|CCDC25_uc003xgf.1_RNA	NM_018246	NP_060716	Q86WR0	CCD25_HUMAN	coiled-coil domain containing 25	85											0		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0223)|KIRC - Kidney renal clear cell carcinoma(542;0.11)|Kidney(114;0.131)|Colorectal(74;0.154)		ACGTTGTTCATCTTGCAGCCT	0.488													18	111					0	0	0	0	C	27606107	C	C	27606107	3	2	285	1	0	0	0	0	1	0	0	0	2813	1435	50	5	389	5	CCDC25	8	27606107	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	460580	27606107	118757915	188	53043											
FUT10	84750	broad.mit.edu	37	chr8	33310959	33310959	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtaggtgcttcctccatttTtgtatgtccatcttgcaaac	7	16	7	11	1	1	0	0	0	1	0	4	0	4	0	3	1	3	4	3	1	3	6	rs139365562		TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:33310959T>C	uc003xje.2	-	3	507	c.151A>G	c.(151-153)AAA>GAA	p.K51E	FUT10_uc003xjc.2_Missense_Mutation_p.K58E|FUT10_uc003xjd.2_Missense_Mutation_p.K23E|FUT10_uc011lbi.1_Missense_Mutation_p.K101E|FUT10_uc003xjf.2_5'UTR|FUT10_uc003xjg.2_Missense_Mutation_p.K23E|FUT10_uc003xjh.2_Missense_Mutation_p.K51E|FUT10_uc003xji.1_Missense_Mutation_p.K51E	NM_032664	NP_116053	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10	51	Lumenal (Potential).				embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			ovary(1)|pancreas(1)	2				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		TCCTCCATTTTTGTATGTCCA	0.378													13	75					0	0	0	0	C	33310959	C	C	33310959	3	2	285	1	0	0	0	0	1	0	0	0	6136	1850	64	5	1300	5	FUT10	8	33310959	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	5704852	33310959	113053063	189	53044											
CHRNA6	8973	broad.mit.edu	37	chr8	42620299	42620299	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatgaactggttgtaatgaGaaaacagtttgtggaagagc	14	11	13	3	0	0	4	0	3	0	2	0	6	0	5	0	2	3	3	0	2	5	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:42620299G>C	uc003xpj.2	-	2	174	c.128C>G	c.(127-129)TCT>TGT	p.S43C	CHRNA6_uc011lcw.1_Missense_Mutation_p.S43C	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	43	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GTTGTAATGAGAAAACAGTTT	0.557													22	106					0	0	0	0	C	42620299	C	C	42620299	3	2	285	1	0	0	0	0	1	0	0	0	3402	942	33	2	1376	2	CHRNA6	8	42620299	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	9309340	42620299	103743723	190	53045											
MOS	4342	broad.mit.edu	37	chr8	57025647	57025647	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgaagacggcagcggagaGggacgggcgcaggtcgtagg	9	3	20	9	6	0	2	0	0	0	2	2	5	0	3	0	6	1	3	0	6	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:57025647G>C	uc011leb.1	-	1	895	c.895C>G	c.(895-897)CTC>GTC	p.L299V		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	299	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			GCAGCGGAGAGGGACGGGCGC	0.687													13	26					0	0	0	0	C	57025647	C	C	57025647	3	2	285	1	0	0	0	0	1	0	0	0	9765	1000	35	4	148	4	MOS	8	57025647	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	14405348	57025647	89338375	191	53046											
ZFHX4	79776	broad.mit.edu	37	chr8	77766927	77766927	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gataaagaagataataattgCagtgaaaaagaaggagggaa	22	6	12	1	0	0	4	0	1	0	3	0	7	0	6	0	2	1	1	0	2	9	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:77766927C>T	uc003yav.2	+	10	8022	c.7635C>T	c.(7633-7635)TGC>TGT	p.C2545C	ZFHX4_uc003yau.1_Silent_p.C2590C|ZFHX4_uc003yaw.1_Silent_p.C2545C	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2545						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATAATAATTGCAGTGAAAAAG	0.473										HNSCC(33;0.089)			10	24					0	0	0	0	T	77766927	T	T	77766927	2	4	285	1	0	0	0	0	0	0	0	1	17702	718	25	4		4	ZFHX4	8	77766927	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	20741280	77766927	68597095	192	53047											
LRRCC1	85444	broad.mit.edu	37	chr8	86047139	86047139	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaagagcaaacatgctcttAtttgggctcaacgaaaagaa	17	8	8	8	1	2	2	1	0	1	2	2	3	2	2	0	1	4	3	0	1	7	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:86047139A>T	uc003ycw.2	+	13	2180	c.2026A>T	c.(2026-2028)ATT>TTT	p.I676F	LRRCC1_uc010maa.1_Missense_Mutation_p.I377F|LRRCC1_uc003ycx.2_Missense_Mutation_p.I583F|LRRCC1_uc003ycy.2_Missense_Mutation_p.I656F	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	676					cell division|mitosis	centriole|nucleus					0						ACATGCTCTTATTTGGGCTCA	0.313													17	53					0	0	0	0	T	86047139	T	T	86047139	3	4	285	1	0	0	0	0	1	0	0	0	9076	449	16	5	2076	5	LRRCC1	8	86047139	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	8280212	86047139	60316883	193	53048											
UBR5	51366	broad.mit.edu	37	chr8	103373366	103373366	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatttacctcaagaagaaagGcagcatgatttggtcccacc	14	9	8	10	0	1	3	1	1	0	2	2	3	2	3	3	2	2	2	3	2	5	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:103373366G>A	uc003ykr.1	-	3	209	c.176C>T	c.(175-177)GCC>GTC	p.A59V	UBR5_uc003yks.1_Missense_Mutation_p.A59V	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	59					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AAGAAGAAAGGCAGCATGATT	0.333													9	44					0	0	0	0	A	103373366	A	A	103373366	3	1	285	1	0	0	0	0	1	0	0	0	16973	1203	42	4	8451	4	UBR5	8	103373366	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	17326227	103373366	42990656	194	53049											
PKHD1L1	93035	broad.mit.edu	37	chr8	110488740	110488740	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctataaacttttataggaaGaagactatgtaattatatca	17	15	5	4	0	2	2	1	0	1	2	2	3	2	3	0	1	1	1	0	1	11	9			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:110488740G>A	uc003yne.2	+	52	8865	c.8761G>A	c.(8761-8763)GAA>AAA	p.E2921K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2921	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTATAGGAAGAAGACTATGT	0.259										HNSCC(38;0.096)			3	4					0	0	0	0	A	110488740	A	A	110488740	3	1	285	1	0	0	0	0	1	0	0	0	12027	943	33	2	8967	2	PKHD1L1	8	110488740	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	7115374	110488740	35875282	195	53050											
RAD21	5885	broad.mit.edu	37	chr8	117866561	117866561	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctgtctctttccacaTcatcaatttcttggtgggcg	5	16	7	13	1	4	0	2	0	2	0	8	0	7	0	3	2	0	0	3	2	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:117866561T>A	uc003yod.2	-	9	1372	c.1084A>T	c.(1084-1086)ATG>TTG	p.M362L		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	362	Interaction with WAPAL and PDS5B.|Interaction with STAG1.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TCTTTCCACATCATCAATTTC	0.383													19	73					0	0	0	0	A	117866561	A	A	117866561	3	1	285	1	0	0	0	0	1	0	0	0	13046	1435	50	5	835	5	RAD21	8	117866561	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	7377821	117866561	28497461	196	53051											
LY6H	4062	broad.mit.edu	37	chr8	144241658	144241658	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctcgggcggcgtgcgcggCgcggggagctgtgcccttcg	1	6	21	13	8	0	0	0	0	0	0	2	1	0	1	1	6	3	2	1	6	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:144241658C>T	uc011lka.1	-						LY6H_uc011lkb.1_5'UTR|LY6H_uc003yxt.2_5'UTR|LY6H_uc011lkc.1_5'UTR	NM_002347	NP_002338	O94772	LY6H_HUMAN	lymphocyte antigen 6 complex, locus H isoform a						nervous system development|organ morphogenesis	anchored to membrane|plasma membrane					0	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GCGTGCGCGGCGCGGGGAGCT	0.736													6	8					0	0	0	0	T	144241658	T	T	144241658	1	4	285	0	1	0	0	0	0	0	0	0	9148	783	27	1		1	LY6H	8	144241658	5'Flank	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	26375097	144241658	2122364	197	53052											
ZNF696	79943	broad.mit.edu	37	chr8	144378762	144378762	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgcgccttcagccgcagctCcttcctccgcgagcaccgcc	4	6	9	22	6	1	0	1	0	0	0	4	1	4	0	8	0	3	3	8	0	0	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr8:144378762C>A	uc003yxy.3	+	3	1326	c.917C>A	c.(916-918)TCC>TAC	p.S306Y		NM_030895	NP_112157	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	306	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			AGCCGCAGCTCCTTCCTCCGC	0.731													3	10					0.004672	0.00482168	1	0	A	144378762	A	A	144378762	3	1	285	1	0	0	0	0	1	0	0	0	18166	855	30	2	923	2	ZNF696	8	144378762	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	137104	144378762	1985260	198	53053											
CDKN2A	1029	broad.mit.edu	37	chr9	21970900	21970900	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tctcagatcatcagtcctcaCctgagggaccttccgcggca	8	9	9	15	2	4	2	4	1	1	1	7	3	6	3	4	2	0	1	4	2	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr9:21970900C>A	uc003zpk.2	-	2	669	c.457_splice	c.e2+1	p.D153_splice	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Splice_Site|CDKN2A_uc010miu.2_Splice_Site|CDKN2A_uc003zpl.2_Splice_Site	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1						cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(12)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCAGTCCTCACCTGAGGGACC	0.597		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			13	5					3.27435e-08	3.63727e-08	1	0	A	21970900	A	A	21970900	5	1	285	1	0	0	0	0	0	0	1	0	3176	521	18	4	20	4	CDKN2A	9	21970900	Splice_Site	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		21970900	119242531	199	53054											
LINGO2	158038	broad.mit.edu	37	chr9	27949285	27949285	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaggtgccatcacccaacAcggtggctcttccattggac	9	8	9	15	1	2	0	1	0	1	0	3	1	3	1	4	4	2	1	4	4	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr9:27949285A>G	uc003zqu.1	-	2	1579	c.1385T>C	c.(1384-1386)GTG>GCG	p.V462A	LINGO2_uc010mjf.1_Missense_Mutation_p.V462A|LINGO2_uc003zqv.1_Missense_Mutation_p.V462A	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	462	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		ATCACCCAACACGGTGGCTCT	0.537													23	17					0	0	0	0	G	27949285	G	G	27949285	3	3	285	1	0	0	0	0	1	0	0	0	8857	159	6	5	439	5	LINGO2	9	27949285	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	5978385	27949285	113264146	200	53055											
TAF1L	138474	broad.mit.edu	37	chr9	32634220	32634220	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatagaaggaagccagcctGccaggcttgcaccctgaggt	11	7	12	11	0	0	2	0	1	0	1	0	3	0	3	4	3	4	2	4	3	4	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr9:32634220G>T	uc003zrg.1	-	1	1448	c.1358C>A	c.(1357-1359)GCA>GAA	p.A453E	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	453					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AAGCCAGCCTGCCAGGCTTGC	0.468													71	50					1.37693e-34	1.94061e-34	1	0	T	32634220	T	T	32634220	3	4	285	1	0	0	0	0	1	0	0	0	15589	1319	46	4	4126	4	TAF1L	9	32634220	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4684935	32634220	108579211	201	53056											
ENHO	375704	broad.mit.edu	37	chr9	34521615	34521615	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccagcagaggatgacccAgagcagcagcagcaagaagc	14	1	14	12	0	0	4	0	1	0	3	0	5	0	5	2	2	6	5	2	2	2	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr9:34521615A>G	uc003zun.1	-	2	503	c.79T>C	c.(79-81)TGG>CGG	p.W27R	ENHO_uc003zuo.2_RNA	NM_198573	NP_940975	Q6UWT2	ENHO_HUMAN	adropin precursor	27						extracellular region					0						AGGATGACCCAGAGCAGCAGC	0.632													9	49					0	0	0	0	G	34521615	G	G	34521615	3	3	285	1	0	0	0	0	1	0	0	0	5143	188	7	5	155	5	ENHO	9	34521615	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	1887395	34521615	106691816	202	53057											
C9orf152	401546	broad.mit.edu	37	chr9	112963437	112963437	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcagcctctgggattcCggttccttgctgagtcatct	4	13	12	12	1	3	1	1	1	2	0	5	2	5	2	3	3	2	3	3	3	0	3	rs138966973	byFrequency	TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr9:112963437C>T	uc011lwk.1	-	2	1065	c.511G>A	c.(511-513)GGA>AGA	p.G171R		NM_001012993	NP_001013011	Q5JTZ5	CI152_HUMAN	hypothetical protein LOC401546	171											0						TCTGGGATTCCGGTTCCTTGC	0.493													26	114					0	0	0	0	T	112963437	T	T	112963437	3	4	285	1	0	0	0	0	1	0	0	0	2475	661	23	1	212	1	C9orf152	9	112963437	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	78441822	112963437	28249994	203	53058											
ZBTB6	10773	broad.mit.edu	37	chr9	125673995	125673995	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tactttgacaaagcttctgtGcacttttccacaatgtgaac	11	14	6	10	0	1	2	0	2	1	0	2	2	2	2	1	0	4	2	1	0	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr9:125673995G>A	uc004bnh.2	-	2	446	c.357C>T	c.(355-357)TGC>TGT	p.C119C		NM_006626	NP_006617	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGCTTCTGTGCACTTTTCCA	0.388													17	73					0	0	0	0	A	125673995	A	A	125673995	2	1	285	1	0	0	0	0	0	0	0	1	17619	1311	46	4		4	ZBTB6	9	125673995	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	12710558	125673995	15539436	204	53059											
TOR1B	27348	broad.mit.edu	37	chr9	132565578	132565578	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggcgttcgagcccatcacCgtgggcctagccatcggggc	5	6	15	15	5	1	0	1	0	0	0	3	1	1	0	4	4	2	1	4	4	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr9:132565578C>T	uc004byk.1	+	1	147	c.87C>T	c.(85-87)ACC>ACT	p.T29T		NM_014506	NP_055321	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B) precursor	29					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding				0		Ovarian(14;0.0586)				AGCCCATCACCGTGGGCCTAG	0.726													11	1					0	0	0	0	T	132565578	T	T	132565578	2	4	285	1	0	0	0	0	0	0	0	1	16441	639	23	1		1	TOR1B	9	132565578	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	6891583	132565578	8647853	205	53060											
SETX	23064	broad.mit.edu	37	chr9	135205410	135205410	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtacagagttagatggcatGgaatgcaatgacagtgaaga	15	9	13	4	0	0	5	0	2	0	3	0	6	0	6	0	2	2	4	0	2	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr9:135205410G>A	uc004cbk.2	-	10	1758	c.1575C>T	c.(1573-1575)TCC>TCT	p.S525S	SETX_uc004cbj.2_Silent_p.S144S|SETX_uc010mzt.2_Silent_p.S144S	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	525					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TAGATGGCATGGAATGCAATG	0.438													102	35					0	0	0	0	A	135205410	A	A	135205410	2	1	285	1	0	0	0	0	0	0	0	1	14206	1335	47	4		4	SETX	9	135205410	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2639832	135205410	6008021	206	53061											
RALGDS	5900	broad.mit.edu	37	chr9	136030665	136030665	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccctcggagacgatgggcgCcaaccagggtgtgagtgtca	8	7	15	11	3	1	2	1	1	0	1	3	4	2	2	3	3	1	0	3	3	1	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr9:136030665C>T	uc011mcw.1	-	6	577	c.296G>A	c.(295-297)GGC>GAC	p.G99D	GBGT1_uc004ccx.2_Missense_Mutation_p.A40T|GBGT1_uc010nab.2_Missense_Mutation_p.G99D|GBGT1_uc011mcx.1_Missense_Mutation_p.A70T|GBGT1_uc004ccw.2_Missense_Mutation_p.A87T|GBGT1_uc010nac.1_5'UTR|GBGT1_uc004ccy.1_Missense_Mutation_p.A87T	NM_001042368	NP_001035827	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	Error:Variant_position_missing_in_Q12967_after_alignment					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		ACGATGGGCGCCAACCAGGGT	0.557			T	CIITA	PMBL|Hodgkin Lymphona|								19	14					0	0	0	0	T	136030665	T	T	136030665	3	4	285	1	0	0	0	0	1	0	0	0	13081	739	26	4		4	RALGDS	9	136030665	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	825255	136030665	5182766	207	53062											
ITIH5	80760	broad.mit.edu	37	chr10	7708844	7708844	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccccaggcacagccccagCagcaggagcatggcggggcg	9	1	16	15	2	0	0	0	0	0	0	0	1	0	1	4	5	5	4	4	5	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:7708844C>A	uc001ijq.2	-	1	91	c.12G>T	c.(10-12)CTG>CTT	p.L4L	ITIH5_uc001ijr.1_Silent_p.L4L	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	4					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						ACAGCCCCAGCAGCAGGAGCA	0.731													5	18					8.12818e-05	8.56498e-05	1	0	A	7708844	A	A	7708844	2	1	285	1	0	0	0	0	0	0	0	1	7946	697	25	4		4	ITIH5	10	7708844	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		7708844	127825903	208	53063											
GPR158	57512	broad.mit.edu	37	chr10	25464376	25464376	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gccatggcttaccccttactCctctgcctcctgcttgctca	4	13	6	18	0	2	0	1	0	1	0	4	0	4	0	6	1	5	3	6	1	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:25464376C>T	uc001isj.2	+	1	87	c.27C>T	c.(25-27)CTC>CTT	p.L9L	LOC100128811_uc010qde.1_Intron	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	9						integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						ACCCCTTACTCCTCTGCCTCC	0.602													23	29					0	0	0	0	T	25464376	T	T	25464376	2	4	285	1	0	0	0	0	0	0	0	1	6701	842	30	2		2	GPR158	10	25464376	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	17755532	25464376	110070371	209	53064											
GAD2	2572	broad.mit.edu	37	chr10	26581417	26581417	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actaccgggtttgaagcgcaTgttgataaatgtttggagtt	10	14	12	5	2	0	2	0	2	0	0	0	3	0	3	1	2	2	5	1	2	4	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:26581417T>C	uc001isp.2	+	14	1913	c.1410T>C	c.(1408-1410)CAT>CAC	p.H470H	GAD2_uc001isq.2_Silent_p.H470H	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	470					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TTGAAGCGCATGTTGATAAAT	0.438													12	20					0	0	0	0	C	26581417	C	C	26581417	2	2	285	1	0	0	0	0	0	0	0	1	6214	1461	51	5		5	GAD2	10	26581417	Silent	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	1117041	26581417	108953330	210	53065											
GDF10	2662	broad.mit.edu	37	chr10	48428899	48428899	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctggccggggtttcagcgcCcggaaggggctgggccacag	5	5	18	13	3	1	0	1	0	0	0	1	1	1	1	4	7	1	2	4	7	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:48428899C>T	uc001jfb.2	-	2	1443	c.987G>A	c.(985-987)CGG>CGA	p.R329R	GDF10_uc009xnp.2_Silent_p.R328R|GDF10_uc009xnq.1_Silent_p.R329R	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	329					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						GTTTCAGCGCCCGGAAGGGGC	0.682													8	18					0	0	0	0	T	48428899	T	T	48428899	2	4	285	1	0	0	0	0	0	0	0	1	6348	610	22	4		4	GDF10	10	48428899	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	21847482	48428899	87105848	211	53066											
C10orf71	118461	broad.mit.edu	37	chr10	50531202	50531202	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgcccgctgaagtttccaaCacccatcagaacagctacca	12	7	7	15	1	1	2	1	1	0	1	2	2	2	2	4	0	5	3	4	0	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:50531202C>A	uc010qgp.1	+	3	951	c.612C>A	c.(610-612)AAC>AAA	p.N204K		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	204											0						AAGTTTCCAACACCCATCAGA	0.532													6	17					0.00198382	0.00205207	1	0	A	50531202	A	A	50531202	3	1	285	1	0	0	0	0	1	0	0	0	1620	477	17	4	614	4	C10orf71	10	50531202	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2102303	50531202	85003545	212	53067											
IPMK	253430	broad.mit.edu	37	chr10	59956302	59956302	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaattttgtagtggttggCtgagatgaaccttcataaac	11	15	9	6	0	2	2	2	2	0	1	2	3	2	2	1	2	2	3	1	2	5	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:59956302C>T	uc001jkb.2	-	6	1109	c.786G>A	c.(784-786)CAG>CAA	p.Q262Q		NM_152230	NP_689416	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	262						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			ovary(1)	1						TAGTGGTTGGCTGAGATGAAC	0.353													13	31					0	0	0	0	T	59956302	T	T	59956302	2	4	285	1	0	0	0	0	0	0	0	1	7831	796	28	4		4	IPMK	10	59956302	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	9425100	59956302	75578445	213	53068											
BICC1	80114	broad.mit.edu	37	chr10	60560767	60560767	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcctgtgccaaaaggcagaCagtggaactattgcaaggca	13	8	11	9	0	0	1	0	0	0	1	1	2	1	2	2	3	3	3	2	3	5	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:60560767C>A	uc001jki.1	+	14	1976	c.1976C>A	c.(1975-1977)ACA>AAA	p.T659K	BICC1_uc001jkj.1_Missense_Mutation_p.T300K	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	659					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						AAAAGGCAGACAGTGGAACTA	0.403													25	46					4.16121e-05	4.42619e-05	1	0	A	60560767	A	A	60560767	3	1	285	1	0	0	0	0	1	0	0	0	1430	478	17	4	2030	4	BICC1	10	60560767	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	604465	60560767	74973980	214	53069											
FAM13C	220965	broad.mit.edu	37	chr10	61012595	61012595	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aattagacatggagagagctGgtggttttacttctttcttt	9	17	10	5	0	2	2	0	0	2	2	2	4	2	3	0	3	2	2	0	3	3	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:61012595G>T	uc001jkn.2	-	13	1630	c.1496C>A	c.(1495-1497)CCA>CAA	p.P499Q	FAM13C_uc001jko.2_Missense_Mutation_p.P401Q|FAM13C_uc010qid.1_Missense_Mutation_p.P415Q|FAM13C_uc010qie.1_Missense_Mutation_p.P416Q|FAM13C_uc010qif.1_Missense_Mutation_p.P521Q	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	499										ovary(2)	2						GGAGAGAGCTGGTGGTTTTAC	0.448													30	50					1.06801e-11	1.26423e-11	1	0	T	61012595	T	T	61012595	3	4	285	1	0	0	0	0	1	0	0	0	5482	1348	47	4	273	4	FAM13C	10	61012595	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	451828	61012595	74522152	215	53070											
PANK1	53354	broad.mit.edu	37	chr10	91404850	91404850	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcgccctgccccccgcgCgccggccccacggcgccggc	1	3	13	24	8	1	0	0	0	1	0	1	0	1	0	8	3	2	0	8	3	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:91404850C>T	uc001kgp.1	-	1	366	c.210G>A	c.(208-210)GCG>GCA	p.A70A	PANK1_uc001kgn.1_5'Flank|PANK1_uc001kgo.1_5'Flank|PANK1_uc009xtu.1_5'Flank	NM_148977	NP_683878	Q8TE04	PANK1_HUMAN	pantothenate kinase 1 isoform alpha	70					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity				0					Bezafibrate(DB01393)	gccccccgcgcgccggcccca	0.647													3	2					0	0	0	0	T	91404850	T	T	91404850	2	4	285	1	0	0	0	0	0	0	0	1	11470	755	27	1		1	PANK1	10	91404850	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	30392255	91404850	44129897	216	53071											
ZNF518A	9849	broad.mit.edu	37	chr10	97917430	97917430	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttatgggcttcaagatgatgGatggaaaacagcatattgta	14	12	11	4	0	1	2	1	1	0	1	1	4	1	4	0	3	2	3	0	3	6	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:97917430G>A	uc001klp.2	+	6	2208	c.1351G>A	c.(1351-1353)GAT>AAT	p.D451N	ZNF518A_uc001klo.1_Intron|ZNF518A_uc001klq.2_Missense_Mutation_p.D451N|ZNF518A_uc001klr.2_Missense_Mutation_p.D451N	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	451					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		CAAGATGATGGATGGAAAACA	0.373													24	80					0	0	0	0	A	97917430	A	A	97917430	3	1	285	1	0	0	0	0	1	0	0	0	18029	1174	41	2	1353	2	ZNF518A	10	97917430	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	6512580	97917430	37617317	217	53072											
C10orf12	26148	broad.mit.edu	37	chr10	98741349	98741372	+	In_Frame_Del	DEL	CGCCAGGATTTAGAGGCAAATGAA	-	-																															agtgtccaaaaacacctttgCgccaggatttagaggcaaat																								rs141108014		TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:98741349_98741372delCGCCAGGATTTAGAGGCAAATGAA	uc001kmv.2	+	1	309_332	c.202_225delCGCCAGGATTTAGAGGCAAATGAA	c.(202-225)CGCCAGGATTTAGAGGCAAATGAAdel	p.RQDLEANE68del	C10orf12_uc009xvg.1_In_Frame_Del_p.RQDLEANE378del	NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	68_75										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AACACCTTTGCGCCAGGATTTAGAGGCAAATGAACAAGATGCAA	0.429													---	---	---								-	98741372	-	-	98741349	7	5	285	1	0	1	0	1	0	0	0	0	1595	768	27	0	204	0	C10orf12	10	98741349	In_Frame_Del	DEL	CGCCAGGATTTAGAGGCAAATGAA	TCGA-DQ-5629-01A-01D-1870-08	823919	98741349	36793398	218	53073											
ZFYVE27	118813	broad.mit.edu	37	chr10	99512906	99512906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtgtctcggctcacggagCggctccgcaagcgctacccc	6	6	13	16	5	2	0	1	0	1	0	4	1	3	1	3	4	3	4	3	4	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:99512906C>T	uc001koo.2	+	10	1209	c.1009C>T	c.(1009-1011)CGG>TGG	p.R337W	ZFYVE27_uc001kon.2_Missense_Mutation_p.R342W|ZFYVE27_uc001koq.2_Missense_Mutation_p.R244W|ZFYVE27_uc010qpa.1_Missense_Mutation_p.R212W|ZFYVE27_uc001kop.2_Missense_Mutation_p.R330W|ZFYVE27_uc010qpb.1_Missense_Mutation_p.R237W|ZFYVE27_uc010qpc.1_RNA|ZFYVE27_uc010qpd.1_Missense_Mutation_p.R298W|ZFYVE27_uc001kok.1_RNA|ZFYVE27_uc001kol.1_Missense_Mutation_p.R337W|ZFYVE27_uc001kom.1_Missense_Mutation_p.R330W	NM_144588	NP_653189	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27 isoform	337	Extracellular (Potential).				cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		GCTCACGGAGCGGCTCCGCAA	0.672													4	9					0	0	0	0	T	99512906	T	T	99512906	3	4	285	1	0	0	0	0	1	0	0	0	17736	759	27	1	1058	1	ZFYVE27	10	99512906	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	771557	99512906	36021841	219	53074											
CUTC	51076	broad.mit.edu	37	chr10	101510142	101510142	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggcaaaaggcaggattgTggtaatgccaggtatttatt	12	12	12	5	0	1	0	1	0	0	0	1	1	1	1	1	5	1	4	1	5	5	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:101510142T>C	uc001kqd.3	+	7	738	c.590T>C	c.(589-591)GTG>GCG	p.V197A	CUTC_uc001kqe.3_Intron	NM_015960	NP_057044	Q9NTM9	CUTC_HUMAN	cutC copper transporter homolog	197					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		GGCAGGATTGTGGTAATGCCA	0.338													20	41					0	0	0	0	C	101510142	C	C	101510142	3	2	285	1	0	0	0	0	1	0	0	0	4080	1696	59	5	616	5	CUTC	10	101510142	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	1997236	101510142	34024605	220	53075											
NRAP	4892	broad.mit.edu	37	chr10	115392938	115392938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttttctcatagtcagcacGgtaattcacctgttggattt	9	17	7	8	1	3	0	3	0	1	0	4	1	3	1	1	2	1	3	1	2	2	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:115392938G>A	uc001laj.2	-	16	1701	c.1537C>T	c.(1537-1539)CGT>TGT	p.R513C	NRAP_uc001lak.2_Missense_Mutation_p.R478C|NRAP_uc001lal.3_Missense_Mutation_p.R513C	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	513	Nebulin 11.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TAGTCAGCACGGTAATTCACC	0.418													15	42					0	0	0	0	A	115392938	A	A	115392938	3	1	285	1	0	0	0	0	1	0	0	0	10692	1116	39	1	3763	1	NRAP	10	115392938	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	13882796	115392938	20141809	221	53076											
ATRNL1	26033	broad.mit.edu	37	chr10	117026300	117026300	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatatatttgggggattttCtagtgtactccttaatgata	10	18	9	4	0	1	1	0	1	1	0	2	2	2	2	1	2	1	2	1	2	7	10			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:117026300C>A	uc001lcg.2	+	12	2185	c.1799C>A	c.(1798-1800)TCT>TAT	p.S600Y		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	600	Kelch 6.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GGGGGATTTTCTAGTGTACTC	0.318													35	57					1.60099e-16	2.00568e-16	1	0	A	117026300	A	A	117026300	3	1	285	1	0	0	0	0	1	0	0	0	1209	913	32	2	1845	2	ATRNL1	10	117026300	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1633362	117026300	18508447	222	53077											
DPYSL4	10570	broad.mit.edu	37	chr10	134008362	134008362	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcacagtggaccacgtcttCcccgacacgggtgtgagcct	7	9	11	14	3	2	1	1	1	1	0	3	3	3	2	4	2	1	0	4	2	0	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:134008362C>T	uc009ybb.2	+	4	481	c.327C>T	c.(325-327)TTC>TTT	p.F109F		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	109					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		ACCACGTCTTCCCCGACACGG	0.647													18	49					0	0	0	0	T	134008362	T	T	134008362	2	4	285	1	0	0	0	0	0	0	0	1	4771	854	30	2		2	DPYSL4	10	134008362	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	16982062	134008362	1526385	223	53078											
STK32C	282974	broad.mit.edu	37	chr10	134041490	134041490	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggctcaccagaggttcAccaggaagacgtgctcgatc	10	6	13	12	2	2	2	2	0	0	2	4	4	2	3	2	4	1	4	2	4	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:134041490A>G	uc001lle.1	-	3	601	c.461T>C	c.(460-462)GTG>GCG	p.V154A	STK32C_uc001lld.1_Missense_Mutation_p.V37A|STK32C_uc010quu.1_Missense_Mutation_p.V167A|STK32C_uc009ybc.1_Missense_Mutation_p.V37A|STK32C_uc009ybd.1_Missense_Mutation_p.V37A|STK32C_uc001llb.2_5'UTR|STK32C_uc001llc.1_RNA	NM_173575	NP_775846	Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	154	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|breast(1)	5		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		CCAGAGGTTCACCAGGAAGAC	0.592													7	9					0	0	0	0	G	134041490	G	G	134041490	3	3	285	1	0	0	0	0	1	0	0	0	15365	159	6	5	1039	5	STK32C	10	134041490	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	33128	134041490	1493257	224	53079											
ADAM8	101	broad.mit.edu	37	chr10	135084731	135084731	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcctggcagcaggtaccgtgCgcacactgggccccctcagc	6	6	12	17	2	1	0	1	0	0	0	2	0	2	0	4	3	4	4	4	3	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr10:135084731C>T	uc010qva.1	-	12	1281	c.1230G>A	c.(1228-1230)GCG>GCA	p.A410A	ADAM8_uc010quz.1_Silent_p.A449A|ADAM8_uc009ybi.2_Silent_p.A449A			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	410					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		AGGTACCGTGCGCACACTGGG	0.687													4	9					0	0	0	0	T	135084731	T	T	135084731	2	4	285	1	0	0	0	0	0	0	0	1	252	755	27	1		1	ADAM8	10	135084731	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1043241	135084731	450016	225	53080											
MUC5B	727897	broad.mit.edu	37	chr11	1162107	1162107	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcgcccaagctccgtgggcaGacctgcggtaagagggctgc	7	5	16	13	3	0	2	0	0	0	2	1	2	1	2	3	3	3	4	3	3	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:1162107G>A	uc009ycr.1	+	15	1824	c.1698G>A	c.(1696-1698)CAG>CAA	p.Q566Q		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	557	VWFD 2.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCGTGGGCAGACCTGCGGTA	0.657													3	5					0	0	0	0	A	1162107	A	A	1162107	2	1	285	1	0	0	0	0	0	0	0	1	10032	957	33	2		2	MUC5B	11	1162107	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08		1162107	133844409	226	53081											
CD81	975	broad.mit.edu	37	chr11	2411680	2411680	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgggtgtggccctgtggctCcgccatgacccgcagaccac	5	7	13	16	2	0	2	0	1	0	1	1	2	1	2	5	3	0	2	5	3	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:2411680C>T	uc001lwf.1	+	2	338	c.105C>T	c.(103-105)CTC>CTT	p.L35L	CD81_uc001lwg.1_Silent_p.L28L	NM_004356	NP_004347	P60033	CD81_HUMAN	CD81 antigen	35	Extracellular (Potential).				activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding				0		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCCTGTGGCTCCGCCATGACC	0.622													24	36					0	0	0	0	T	2411680	T	T	2411680	2	4	285	1	0	0	0	0	0	0	0	1	3054	842	30	2		2	CD81	11	2411680	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1249573	2411680	132594836	227	53082											
DENND5A	23258	broad.mit.edu	37	chr11	9182329	9182329	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggctggcaatcagggtgttCtcttccacccctgtgatgtt	6	13	11	11	0	2	1	1	1	1	0	4	1	3	1	3	3	0	4	3	3	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:9182329C>T	uc001mhl.2	-	12	2622	c.2367G>A	c.(2365-2367)GAG>GAA	p.E789E	DENND5A_uc001mhk.2_Silent_p.E132E|DENND5A_uc010rbw.1_Silent_p.E789E|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	789	RUN 1.									liver(1)	1						TCAGGGTGTTCTCTTCCACCC	0.512													29	55					0	0	0	0	T	9182329	T	T	9182329	2	4	285	1	0	0	0	0	0	0	0	1	4458	912	32	2		2	DENND5A	11	9182329	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	6770649	9182329	125824187	228	53083											
ANO3	63982	broad.mit.edu	37	chr11	26529699	26529699	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacctctgttcaaagatggcAaaaagagaattgattacatc	16	10	8	7	0	2	3	1	1	1	2	3	5	2	3	1	1	1	2	1	1	5	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:26529699A>T	uc001mqt.3	+	5	626	c.481A>T	c.(481-483)AAA>TAA	p.K161*	ANO3_uc010rdr.1_Nonsense_Mutation_p.K145*|ANO3_uc010rds.1_Nonsense_Mutation_p.K15*|ANO3_uc010rdt.1_Nonsense_Mutation_p.K15*	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	161	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAAAGATGGCAAAAAGAGAAT	0.338													8	32					0	0	0	0	T	26529699	T	T	26529699	4	4	285	1	0	0	0	0	0	1	0	0	698	131	5	5	499	5	ANO3	11	26529699	Nonsense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	17347370	26529699	108476817	229	53084											
MTCH2	23788	broad.mit.edu	37	chr11	47653242	47653242	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gatgagggtagcagcagaacGagcgatcatctctcgagttg	11	8	14	8	3	2	2	1	1	1	1	4	6	2	2	0	1	4	4	0	1	2	2	rs146228351	by1000genomes	TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:47653242G>C	uc010rho.1	-	6	580	c.391C>G	c.(391-393)CGT>GGT	p.R131G	MTCH2_uc001nge.2_Missense_Mutation_p.R4G|MTCH2_uc010rhp.1_Intron	NM_014342	NP_055157	Q9Y6C9	MTCH2_HUMAN	mitochondrial carrier 2	131	Solcar 2.				transport	integral to membrane|mitochondrial inner membrane					0						GCAGCAGAACGAGCGATCATC	0.423													16	45					0	0	0	0	C	47653242	C	C	47653242	3	2	285	1	0	0	0	0	1	0	0	0	9967	1058	37	3	552	3	MTCH2	11	47653242	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	21123543	47653242	87353274	230	53085											
OR5D14	219436	broad.mit.edu	37	chr11	55563127	55563127	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagattcctctcttccttgtGtttctgctcatgtatgttat	5	20	6	10	0	3	1	1	0	2	1	6	1	5	1	2	0	1	4	2	0	2	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:55563127G>A	uc010rim.1	+	1	96	c.96G>A	c.(94-96)GTG>GTA	p.V32V		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TCTTCCTTGTGTTTCTGCTCA	0.388													15	76					0	0	0	0	A	55563127	A	A	55563127	2	1	285	1	0	0	0	0	0	0	0	1	11209	1364	48	4		4	OR5D14	11	55563127	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	7909885	55563127	79443389	231	53086											
OR8H2	390151	broad.mit.edu	37	chr11	55872956	55872956	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcctcgctctcatcacTgggccttatgtgattggctt	4	15	9	13	1	3	1	2	1	2	0	5	1	3	1	2	2	1	2	2	2	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:55872956T>G	uc010riy.1	+	1	438	c.438T>G	c.(436-438)ACT>ACG	p.T146T		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CTCTCATCACTGGGCCTTATG	0.453										HNSCC(53;0.14)			66	100					0	0	0	0	G	55872956	G	G	55872956	2	3	285	1	0	0	0	0	0	0	0	1	11292	1567	55	5		5	OR8H2	11	55872956	Silent	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	309829	55872956	79133560	232	53087											
OR8H2	390151	broad.mit.edu	37	chr11	55873223	55873223	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattccacttcaggaaagcaGaaagctttctctacttgcgt	12	12	7	10	1	2	1	1	0	1	1	4	2	3	2	1	1	4	2	1	1	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:55873223G>C	uc010riy.1	+	1	705	c.705G>C	c.(703-705)CAG>CAC	p.Q235H		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CAGGAAAGCAGAAAGCTTTCT	0.383										HNSCC(53;0.14)			39	43					0	0	0	0	C	55873223	C	C	55873223	3	2	285	1	0	0	0	0	1	0	0	0	11292	933	33	2	707	2	OR8H2	11	55873223	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	267	55873223	79133293	233	53088											
GLYATL2	219970	broad.mit.edu	37	chr11	58604861	58604861	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtataatgatcctggtcatCtttcatctcctgatataaca	11	15	6	9	0	4	2	2	2	2	0	6	2	5	2	2	2	1	1	2	2	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:58604861C>T	uc001nnd.3	-	4	327	c.196G>A	c.(196-198)GAT>AAT	p.D66N	GLYATL2_uc009ymq.2_Missense_Mutation_p.D66N	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	66						mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	TCCTGGTCATCTTTCATCTCC	0.363													8	64					0	0	0	0	T	58604861	T	T	58604861	3	4	285	1	0	0	0	0	1	0	0	0	6518	913	32	2	700	2	GLYATL2	11	58604861	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2731638	58604861	76401655	234	53089											
OR4D11	219986	broad.mit.edu	37	chr11	59271125	59271125	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccaagaccagagtttggTcttgtttctttttttatgtc	7	19	7	8	0	2	2	0	0	2	2	4	2	3	2	2	1	0	2	2	1	2	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:59271125T>A	uc001noa.1	+	1	77	c.77T>A	c.(76-78)GTC>GAC	p.V26D		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CAGAGTTTGGTCTTGTTTCTT	0.433													25	72					0	0	0	0	A	59271125	A	A	59271125	3	1	285	1	0	0	0	0	1	0	0	0	11109	1667	58	5	79	5	OR4D11	11	59271125	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	666264	59271125	75735391	235	53090											
METTL12	751071	broad.mit.edu	37	chr11	62434253	62434253	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcagaacctgggggctgtGgcttcttcaggctctttcca	5	12	12	12	0	4	1	2	0	2	1	5	1	5	1	2	4	1	4	2	4	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:62434253G>A	uc001nug.1	+	3	712	c.453G>A	c.(451-453)GTG>GTA	p.V151V	C11orf48_uc001nue.2_Intron|C11orf48_uc001nuf.2_Intron|METTL12_uc001nuh.2_3'UTR|METTL12_uc010rmc.1_RNA	NM_001043229	NP_001036694	A8MUP2	MTL12_HUMAN	methyltransferase like 12 precursor	151						mitochondrion	methyltransferase activity				0						TGGGGGCTGTGGCTTCTTCAG	0.592													14	51					0	0	0	0	A	62434253	A	A	62434253	2	1	285	1	0	0	0	0	0	0	0	1	9549	1335	47	4		4	METTL12	11	62434253	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	3163128	62434253	72572263	236	53091											
SLC22A12	116085	broad.mit.edu	37	chr11	64359366	64359366	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctggagcgaggccgacaCggagccgtgtgtggatggct	7	6	18	10	4	0	0	0	0	0	0	0	5	0	3	2	5	3	2	2	5	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:64359366C>G	uc001oam.1	+	1	1085	c.338C>G	c.(337-339)ACG>AGG	p.T113R	SLC22A12_uc009ypr.1_Missense_Mutation_p.T113R|SLC22A12_uc001oal.1_5'UTR|SLC22A12_uc009yps.1_Missense_Mutation_p.T113R|SLC22A12_uc001oan.1_Missense_Mutation_p.T113R|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	113					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						GAGGCCGACACGGAGCCGTGT	0.672													9	26					0	0	0	0	G	64359366	G	G	64359366	3	3	285	1	0	0	0	0	1	0	0	0	14508	536	19	3	340	3	SLC22A12	11	64359366	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1925113	64359366	70647150	237	53092											
SNX15	29907	broad.mit.edu	37	chr11	64795103	64795103	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaccgagtacaaagtaaccGcgcaggtgaggtggggccca	12	4	14	11	3	0	1	0	1	0	0	0	2	0	1	3	4	2	3	3	4	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:64795103G>C	uc001oci.3	+	4	747	c.94G>C	c.(94-96)GCG>CCG	p.A32P	SNX15_uc009ypy.2_Missense_Mutation_p.A32P|SNX15_uc001ocj.2_Missense_Mutation_p.A32P|SNX15_uc001ock.2_Missense_Mutation_p.A32P	NM_013306	NP_037438	Q9NRS6	SNX15_HUMAN	sorting nexin 15 isoform A	32	PX.				cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			ovary(1)	1						CAAAGTAACCGCGCAGGTGAG	0.577											OREG0021069	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	26					0	0	0	0	C	64795103	C	C	64795103	3	2	285	1	0	0	0	0	1	0	0	0	14950	1087	38	3	96	3	SNX15	11	64795103	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	435737	64795103	70211413	238	53093											
NLRX1	79671	broad.mit.edu	37	chr11	119050721	119050721	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcaagaagaagctgggcaAgctgggccggcaggtgctgc	10	5	16	10	1	1	2	1	0	0	2	1	2	1	2	1	4	4	5	1	4	4	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:119050721A>T	uc001pvu.2	+	7	2206	c.1991A>T	c.(1990-1992)AAG>ATG	p.K664M	NLRX1_uc010rzc.1_Missense_Mutation_p.K486M|NLRX1_uc001pvv.2_Missense_Mutation_p.K664M|NLRX1_uc001pvw.2_Missense_Mutation_p.K664M|NLRX1_uc001pvx.2_Missense_Mutation_p.K664M	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	664	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		AAGCTGGGCAAGCTGGGCCGG	0.602													5	22					0	0	0	0	T	119050721	T	T	119050721	3	4	285	1	0	0	0	0	1	0	0	0	10539	72	3	5	2013	5	NLRX1	11	119050721	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	54255618	119050721	15955795	239	53094											
HSPA8	3312	broad.mit.edu	37	chr11	122930365	122930365	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctctactgggtccagggtGccacggaacaggtcagcatt	8	10	12	11	1	2	0	1	0	1	0	4	1	3	1	2	4	4	1	2	4	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:122930365G>C	uc001pyo.2	-	5	1014	c.936C>G	c.(934-936)GGC>GGG	p.G312G	HSPA8_uc009zbc.2_Silent_p.G76G|HSPA8_uc001pyp.2_Silent_p.G312G|HSPA8_uc010rzu.1_Silent_p.G235G|HSPA8_uc009zbd.1_Silent_p.G312G	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	312	Interaction with BAG1.				cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GGTCCAGGGTGCCACGGAACA	0.478													23	39					0	0	0	0	C	122930365	C	C	122930365	2	2	285	1	0	0	0	0	0	0	0	1	7455	1306	46	4		4	HSPA8	11	122930365	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	3879644	122930365	12076151	240	53095											
ASAM	79827	broad.mit.edu	37	chr11	122944443	122944443	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcctgaggaagaggagctGggtttcacaagacgggcttt	10	8	16	7	1	1	3	1	1	0	2	1	6	1	5	1	4	2	3	1	4	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:122944443G>C	uc001pyt.2	-	7	1220	c.861C>G	c.(859-861)CCC>CCG	p.P287P		NM_024769	NP_079045	Q9H6B4	CLMP_HUMAN	adipocyte-specific adhesion molecule precursor	287	Cytoplasmic (Potential).					integral to membrane|tight junction					0		Breast(109;0.0025)|Lung NSC(97;0.0179)|all_lung(97;0.0182)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.73e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		AAGAGGAGCTGGGTTTCACAA	0.507													17	76					0	0	0	0	C	122944443	C	C	122944443	2	2	285	1	0	0	0	0	0	0	0	1	1011	1335	47	4		4	ASAM	11	122944443	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	14078	122944443	12062073	241	53096											
OR8B3	390271	broad.mit.edu	37	chr11	124266520	124266520	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagacagagcaatgacatgaGagctacaagtactgaaggct	16	6	12	7	0	0	5	0	3	0	3	0	7	0	5	0	1	4	4	0	1	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:124266520G>C	uc010saj.1	-	1	728	c.728C>G	c.(727-729)TCT>TGT	p.S243C	OR8B2_uc001qab.3_Intron	NM_001005467	NP_001005467	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AATGACATGAGAGCTACAAGT	0.383													25	89					0	0	0	0	C	124266520	C	C	124266520	3	2	285	1	0	0	0	0	1	0	0	0	11282	942	33	2	215	2	OR8B3	11	124266520	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1322077	124266520	10739996	242	53097											
OR8B3	390271	broad.mit.edu	37	chr11	124267068	124267068	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagagattgaagaggaaataGtacattggtgtgtggaggtg	13	10	17	1	0	0	3	0	1	0	2	0	7	0	5	0	4	1	1	0	4	4	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:124267068G>A	uc010saj.1	-	1	180	c.180C>T	c.(178-180)TAC>TAT	p.Y60Y	OR8B2_uc001qab.3_Intron	NM_001005467	NP_001005467	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGAGGAAATAGTACATTGGTG	0.378													23	22					0	0	0	0	A	124267068	A	A	124267068	2	1	285	1	0	0	0	0	0	0	0	1	11282	1024	36	4		4	OR8B3	11	124267068	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	548	124267068	10739448	243	53098											
CHEK1	1111	broad.mit.edu	37	chr11	125525182	125525182	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggaagctgattgatattgtGagcagccagaagatttggct	11	11	14	5	0	0	5	0	3	0	2	0	6	0	6	1	2	3	3	1	2	3	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr11:125525182G>C	uc009zbo.2	+	13	2290	c.1398G>C	c.(1396-1398)GTG>GTC	p.V466V	CHEK1_uc010sbh.1_Silent_p.V482V|CHEK1_uc010sbi.1_Silent_p.V432V|CHEK1_uc001qcf.3_Silent_p.V466V|CHEK1_uc009zbp.2_Silent_p.V466V|CHEK1_uc001qcg.3_Silent_p.V466V|CHEK1_uc009zbq.2_Silent_p.V422V|CHEK1_uc001qci.1_RNA|CHEK1_uc001qcj.2_Silent_p.V114V	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	466	Autoinhibitory region.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		TTGATATTGTGAGCAGCCAGA	0.393								Other_conserved_DNA_damage_response_genes					9	18					0	0	0	0	C	125525182	C	C	125525182	2	2	285	1	0	0	0	0	0	0	0	1	3349	1277	45	2		2	CHEK1	11	125525182	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1258114	125525182	9481334	244	53099											
VAMP1	6843	broad.mit.edu	37	chr12	6573649	6573649	+	Frame_Shift_Del	DEL	T	-	-																															tacattctcaagtaaaaaagTagactggacacaggaatcag																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:6573649delT	uc001qok.2	-	5	490	c.344delA	c.(343-345)TACfs	p.Y115fs	TAPBPL_uc001qoi.1_Intron|VAMP1_uc001qoj.2_Intron|VAMP1_uc001qol.2_3'UTR	NM_014231	NP_055046	P23763	VAMP1_HUMAN	vesicle-associated membrane protein 1 isoform 1	115	Helical; Anchor for type IV membrane protein; (Potential).				neurotransmitter secretion|vesicle-mediated transport	cell junction|endocytic vesicle membrane|integral to plasma membrane|mitochondrial outer membrane|synaptic vesicle membrane|synaptosome	protein binding				0					Botulinum Toxin Type B(DB00042)	AGTAAAAAAGTAGACTGGACA	0.473													---	---	---								-	6573649	-	-	6573649	7	5	285	1	0	1	0	1	0	0	0	0	17180	1638	57	0	31	0	VAMP1	12	6573649	Frame_Shift_Del	DEL	T	TCGA-DQ-5629-01A-01D-1870-08		6573649	127278246	245	53100											
ACSM4	341392	broad.mit.edu	37	chr12	7457112	7457112	+	Frame_Shift_Del	DEL	G	-	-																															tgcagatgtgctggaccagtGgtcccaaaaggagaaggtat																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:7457112delG	uc001qsx.1	+	1	185	c.185delG	c.(184-186)TGGfs	p.W62fs		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	62					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						CTGGACCAGTGGTCCCAAAAG	0.468													---	---	---								-	7457112	-	-	7457112	7	5	285	1	0	1	0	1	0	0	0	0	186	1357	47	0	187	0	ACSM4	12	7457112	Frame_Shift_Del	DEL	G	TCGA-DQ-5629-01A-01D-1870-08	883463	7457112	126394783	246	53101											
CD163L1	283316	broad.mit.edu	37	chr12	7559427	7559446	+	Frame_Shift_Del	DEL	CTTAGTTCAAGATCACTACT	-	-																															ggttagttccacctacaagcCttagttcaagatcactacta																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:7559427_7559446delCTTAGTTCAAGATCACTACT	uc001qsy.2	-	5	795_814	c.769_788delAGTAGTGATCTTGAACTAAG	c.(769-789)AGTAGTGATCTTGAACTAAGGfs	p.S257fs	CD163L1_uc010sge.1_Frame_Shift_Del_p.S267fs	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	257_263	SRCR 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ACCTACAAGCCTTAGTTCAAGATCACTACTATCTGAAACA	0.414													---	---	---								-	7559446	-	-	7559427	7	5	285	1	0	1	0	1	0	0	0	0	2983	681	24	0	3633	0	CD163L1	12	7559427	Frame_Shift_Del	DEL	CTTAGTTCAAGATCACTACT	TCGA-DQ-5629-01A-01D-1870-08	102315	7559427	126292468	247	53102											
PZP	5858	broad.mit.edu	37	chr12	9318716	9318716	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accgtttcagggactggcccTgaactttgttcattatttaa	9	15	8	9	1	2	1	2	1	0	0	2	2	2	2	2	2	1	2	2	2	3	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:9318716T>C	uc001qvl.2	-	18	2219	c.2190A>G	c.(2188-2190)TCA>TCG	p.S730S	PZP_uc009zgl.2_Silent_p.S599S|PZP_uc010sgo.1_RNA|PZP_uc009zgm.1_Silent_p.S62S	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						GGACTGGCCCTGAACTTTGTT	0.413													41	96					0	0	0	0	C	9318716	C	C	9318716	2	2	285	1	0	0	0	0	0	0	0	1	12934	1567	55	5		5	PZP	12	9318716	Silent	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	1759289	9318716	124533179	248	53103											
SLCO1C1	53919	broad.mit.edu	37	chr12	20864365	20864365	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcctccaattccactctcagCatctctccgtgtctcctaga	7	13	4	17	1	3	1	1	0	3	1	10	1	7	1	5	0	1	1	5	0	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:20864365C>A	uc001rej.3	+	6	805	c.450C>A	c.(448-450)AGC>AGA	p.S150R	SLCO1C1_uc010sii.1_Missense_Mutation_p.S150R|SLCO1C1_uc010sij.1_Missense_Mutation_p.S150R|SLCO1C1_uc009zip.2_5'UTR|SLCO1C1_uc001rei.2_Missense_Mutation_p.S150R|SLCO1C1_uc010sik.1_Missense_Mutation_p.S32R	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	150	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					CCACTCTCAGCATCTCTCCGT	0.348													22	114					5.35356e-11	6.27131e-11	1	0	A	20864365	A	A	20864365	3	1	285	1	0	0	0	0	1	0	0	0	14789	709	25	4	464	4	SLCO1C1	12	20864365	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	11545649	20864365	112987530	249	53104											
ADAMTS20	80070	broad.mit.edu	37	chr12	43944888	43944888	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaaggatgcatcggcggtcaGgttcagctggaagagctgcc	10	7	15	9	2	2	1	2	0	0	1	3	3	2	3	1	5	4	4	1	5	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:43944888G>T	uc010skx.1	-	2	277	c.277C>A	c.(277-279)CTG>ATG	p.L93M		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	93						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCGGCGGTCAGGTTCAGCTGG	0.667													22	20					3.7963e-18	4.89181e-18	1	0	T	43944888	T	T	43944888	3	4	285	1	0	0	0	0	1	0	0	0	266	991	35	4	5606	4	ADAMTS20	12	43944888	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	23080523	43944888	89907007	250	53105											
DDX23	9416	broad.mit.edu	37	chr12	49229995	49229995	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctcagccacaccaatgaTgtcacgattctgtagcccaa	12	9	7	13	1	3	1	2	1	2	0	4	2	3	1	3	0	2	1	3	0	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:49229995T>C	uc001rsm.2	-	11	1382	c.1291A>G	c.(1291-1293)ATC>GTC	p.I431V		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	431	Helicase ATP-binding.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						ACACCAATGATGTCACGATTC	0.507													47	126					0	0	0	0	C	49229995	C	C	49229995	3	2	285	1	0	0	0	0	1	0	0	0	4367	1464	51	5	1199	5	DDX23	12	49229995	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	5285107	49229995	84621900	251	53106											
KRT72	140807	broad.mit.edu	37	chr12	52979944	52979944	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctcctgccccagcattggtgCtgctgatgacggctggaatg	6	10	13	12	1	0	2	0	2	0	0	1	3	1	3	3	3	4	4	3	3	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:52979944C>A	uc001sar.2	-	9	1444	c.1358G>T	c.(1357-1359)AGC>ATC	p.S453I	KRT72_uc001saq.2_Missense_Mutation_p.S453I|KRT72_uc010sns.1_Missense_Mutation_p.S411I|KRT72_uc010snt.1_Missense_Mutation_p.S265I	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	453	Tail.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		AGCATTGGTGCTGCTGATGAC	0.587													17	18					9.16793e-09	1.02599e-08	1	0	A	52979944	A	A	52979944	3	1	285	1	0	0	0	0	1	0	0	0	8524	797	28	4	181	4	KRT72	12	52979944	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	3749949	52979944	80871951	252	53107											
OR6C76	390326	broad.mit.edu	37	chr12	55820894	55820894	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcctatgctgaatccatttaTttacactctaagaaaccagc	13	13	4	11	0	1	2	0	1	1	1	3	2	3	2	3	0	4	1	3	0	6	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:55820894T>C	uc010spm.1	+	1	857	c.857T>C	c.(856-858)ATT>ACT	p.I286T		NM_001005183	NP_001005183	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AATCCATTTATTTACACTCTA	0.348													23	20					0	0	0	0	C	55820894	C	C	55820894	3	2	285	1	0	0	0	0	1	0	0	0	11254	1493	52	5	859	5	OR6C76	12	55820894	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	2840950	55820894	78031001	253	53108											
LGR5	8549	broad.mit.edu	37	chr12	71978435	71978435	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catcacttatgacctgcctcCcagttccgtgccatcaccag	8	10	6	17	1	2	1	2	1	0	0	4	1	4	1	6	0	2	1	6	0	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:71978435C>T	uc001swl.2	+	18	2693	c.2645C>T	c.(2644-2646)CCC>CTC	p.P882L	LGR5_uc001swm.2_Missense_Mutation_p.P858L|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	882	Cytoplasmic (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						GACCTGCCTCCCAGTTCCGTG	0.448													66	75					0	0	0	0	T	71978435	T	T	71978435	3	4	285	1	0	0	0	0	1	0	0	0	8798	623	22	4	2715	4	LGR5	12	71978435	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	16157541	71978435	61873460	254	53109											
NEDD1	121441	broad.mit.edu	37	chr12	97303599	97303599	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaaatatgggatgcttcatCtatgacattggtggataaat	14	14	9	4	0	2	1	1	1	1	0	2	3	2	3	0	3	1	1	0	3	6	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:97303599C>G	uc001teu.3	+	3	401	c.62C>G	c.(61-63)TCT>TGT	p.S21C	NEDD1_uc001tev.3_Missense_Mutation_p.S21C|NEDD1_uc010svc.1_Intron|NEDD1_uc001tew.2_Missense_Mutation_p.S28C|NEDD1_uc001tex.2_5'Flank	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	21	WD 1.				cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						GATGCTTCATCTATGACATTG	0.348													14	17					0	0	0	0	G	97303599	G	G	97303599	3	3	285	1	0	0	0	0	1	0	0	0	10363	913	32	2	89	2	NEDD1	12	97303599	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	25325164	97303599	36548296	255	53110											
PIWIL1	9271	broad.mit.edu	37	chr12	130847589	130847589	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgcccagccggatcatcGtgtaccgcgatggcgtagga	9	7	13	12	5	1	0	1	0	0	0	2	3	1	2	3	3	3	2	3	3	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr12:130847589G>A	uc001uik.2	+	18	2185	c.2095G>A	c.(2095-2097)GTG>ATG	p.V699M	PIWIL1_uc001uij.1_Missense_Mutation_p.V699M	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	699	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CCGGATCATCGTGTACCGCGA	0.488													8	44					0	0	0	0	A	130847589	A	A	130847589	3	1	285	1	0	0	0	0	1	0	0	0	12012	1145	40	1	2161	1	PIWIL1	12	130847589	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	33543990	130847589	3004306	256	53111											
IFT88	8100	broad.mit.edu	37	chr13	21212594	21212594	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atggtgattatgagaaggccGctgaattctataaagaggct	13	11	12	5	1	1	4	0	3	1	2	1	5	1	4	1	3	0	2	1	3	6	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr13:21212594G>A	uc001unh.2	+	19	1933	c.1537G>A	c.(1537-1539)GCT>ACT	p.A513T	IFT88_uc001uni.2_Missense_Mutation_p.A504T|IFT88_uc001unj.2_Missense_Mutation_p.A503T|IFT88_uc010tcq.1_Missense_Mutation_p.A484T|IFT88_uc001unk.2_Missense_Mutation_p.A259T	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	513	TPR 7.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TGAGAAGGCCGCTGAATTCTA	0.338													73	52					0	0	0	0	A	21212594	A	A	21212594	3	1	285	1	0	0	0	0	1	0	0	0	7605	1087	38	1	1603	1	IFT88	13	21212594	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08		21212594	93957284	257	53112											
TRPC4	7223	broad.mit.edu	37	chr13	38357101	38357101	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttgcaggtacctgtttttCtccactaggttttttgtggt	4	21	9	7	0	1	0	0	0	1	0	2	0	1	0	2	3	2	4	2	3	2	9			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr13:38357101C>A	uc001uws.2	-	2	605	c.370G>T	c.(370-372)GAA>TAA	p.E124*	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Nonsense_Mutation_p.E124*|TRPC4_uc010tey.1_Nonsense_Mutation_p.E124*|TRPC4_uc010abw.2_Nonsense_Mutation_p.E124*|TRPC4_uc010abx.2_Nonsense_Mutation_p.E124*|TRPC4_uc010aby.2_Nonsense_Mutation_p.E124*	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	124	ANK 3.|Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ACCTGTTTTTCTCCACTAGGT	0.289													42	30					7.05121e-23	9.40857e-23	1	0	A	38357101	A	A	38357101	4	1	285	1	0	0	0	0	0	1	0	0	16647	922	32	2	2618	2	TRPC4	13	38357101	Nonsense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	17144507	38357101	76812777	258	53113											
LCP1	3936	broad.mit.edu	37	chr13	46721147	46721147	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agttcaacttggggttccctCggacaacatctgtggctgtg	7	12	12	10	1	2	0	1	0	1	0	4	1	3	1	1	4	2	3	1	4	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr13:46721147C>T	uc001vaz.3	-	10	1196	c.1070G>A	c.(1069-1071)CGA>CAA	p.R357Q	LCP1_uc001vay.3_5'Flank|LCP1_uc001vba.3_Missense_Mutation_p.R357Q	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	357	CH 2.|Actin-binding 1.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		GGGGTTCCCTCGGACAACATC	0.547			T	BCL6	NHL 								10	86					0	0	0	0	T	46721147	T	T	46721147	3	4	285	1	0	0	0	0	1	0	0	0	8731	884	31	1	841	1	LCP1	13	46721147	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	8364046	46721147	68448731	259	53114											
THSD1	55901	broad.mit.edu	37	chr13	52951683	52951683	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgtcatagaaggcaaactCagggtgagtggggaagcttt	12	10	14	5	0	2	2	2	1	0	1	2	3	2	3	0	4	2	2	0	4	4	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr13:52951683C>G	uc001vgo.2	-	5	2967	c.2422G>C	c.(2422-2424)GAG>CAG	p.E808Q	THSD1_uc001vgp.2_Missense_Mutation_p.E755Q|THSD1_uc010tgz.1_Missense_Mutation_p.E429Q|THSD1_uc010aea.2_Missense_Mutation_p.E269Q	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	808	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		AAGGCAAACTCAGGGTGAGTG	0.488													32	31					0	0	0	0	G	52951683	G	G	52951683	3	3	285	1	0	0	0	0	1	0	0	0	15943	835	29	2	140	2	THSD1	13	52951683	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	6230536	52951683	62218195	260	53115											
DIAPH3	81624	broad.mit.edu	37	chr13	60737866	60737866	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcccagcggctgagccttggGccgggtggtgcagccgcggc	3	6	18	14	4	0	1	0	1	0	0	1	1	1	1	4	5	4	2	4	5	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr13:60737866G>A	uc001vht.2	-	1	254	c.35C>T	c.(34-36)GCC>GTC	p.A12V	DIAPH3_uc001vhw.1_Missense_Mutation_p.A12V|DIAPH3_uc010aed.1_Missense_Mutation_p.A12V|DIAPH3_uc010aee.1_Missense_Mutation_p.A12V	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	12					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TGAGCCTTGGGCCGGGTGGTG	0.682													11	8					0	0	0	0	A	60737866	A	A	60737866	3	1	285	1	0	0	0	0	1	0	0	0	4542	1203	42	4	3678	4	DIAPH3	13	60737866	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	7786183	60737866	54432012	261	53116											
KLHL1	57626	broad.mit.edu	37	chr13	70314562	70314562	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctacaccaactgtgctccgaGcaattgacatactggctaca	12	9	7	13	1	0	1	0	1	0	0	1	2	1	1	2	1	6	3	2	1	5	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr13:70314562G>T	uc001vip.2	-	8	2560	c.1766C>A	c.(1765-1767)GCT>GAT	p.A589D	KLHL1_uc010thm.1_Missense_Mutation_p.A528D	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	589	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TGTGCTCCGAGCAATTGACAT	0.378													22	36					5.35356e-11	6.27131e-11	1	0	T	70314562	T	T	70314562	3	4	285	1	0	0	0	0	1	0	0	0	8404	971	34	4	496	4	KLHL1	13	70314562	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	9576696	70314562	44855316	262	53117											
TBC1D4	9882	broad.mit.edu	37	chr13	75898460	75898460	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcagtgaaggaaggggcaGagaaggaagtgtgaagactt	14	5	19	3	0	0	4	0	2	0	2	0	7	0	6	0	5	0	2	0	5	5	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr13:75898460G>A	uc001vjl.1	-	11	2458	c.2111C>T	c.(2110-2112)TCT>TTT	p.S704F	TBC1D4_uc010aer.2_Missense_Mutation_p.S704F|TBC1D4_uc010aes.2_Intron	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	704	Ser-rich.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GGAAGGGGCAGAGAAGGAAGT	0.443													27	34					0	0	0	0	A	75898460	A	A	75898460	3	1	285	1	0	0	0	0	1	0	0	0	15688	942	33	2	1829	2	TBC1D4	13	75898460	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	5583898	75898460	39271418	263	53118											
POTEG	404785	broad.mit.edu	37	chr14	19553564	19553564	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggcacttctggagaccacGacgattctgctatgaagaca	11	9	11	10	2	2	3	0	1	2	2	2	6	2	3	1	2	1	2	1	2	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:19553564G>T	uc001vuz.1	+	1	200	c.148G>T	c.(148-150)GAC>TAC	p.D50Y	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	50										ovary(1)	1						TGGAGACCACGACGATTCTGC	0.607													63	537					1.31215e-26	1.79872e-26	1	0	T	19553564	T	T	19553564	3	4	285	1	0	0	0	0	1	0	0	0	12321	1058	37	3	150	3	POTEG	14	19553564	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08		19553564	87795976	264	53119											
OR4Q3	441669	broad.mit.edu	37	chr14	20216207	20216207	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagccaacagtggtctgctGtctcttgtctgcttcttggt	5	16	10	10	0	4	0	0	0	4	0	5	0	4	0	1	2	4	2	1	2	2	4	rs150293428	byFrequency	TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:20216207G>C	uc010tkt.1	+	1	621	c.621G>C	c.(619-621)CTG>CTC	p.L207L		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGGTCTGCTGTCTCTTGTCT	0.488													26	95					0	0	0	0	C	20216207	C	C	20216207	2	2	285	1	0	0	0	0	0	0	0	1	11135	1364	48	4		4	OR4Q3	14	20216207	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	662643	20216207	87133333	265	53120											
OR11H6	122748	broad.mit.edu	37	chr14	20692620	20692620	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgtattccctctggtgctgGtcgaactaaagctttctcca	7	15	8	11	1	2	0	0	0	2	0	5	1	3	0	2	2	3	3	2	2	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:20692620G>C	uc010tlc.1	+	1	752	c.752G>C	c.(751-753)GGT>GCT	p.G251A		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	251	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TCTGGTGCTGGTCGAACTAAA	0.478													15	12					0	0	0	0	C	20692620	C	C	20692620	3	2	285	1	0	0	0	0	1	0	0	0	10983	1261	44	4	754	4	OR11H6	14	20692620	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	476413	20692620	86656920	266	53121											
MYH7	4625	broad.mit.edu	37	chr14	23887419	23887419	+	Frame_Shift_Del	DEL	T	-	-																															tcaggctgctcagaactcacTtggcctcctcgagctcctca																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:23887419delT	uc001wjx.2	-	30	4275	c.4169delA	c.(4168-4170)AAGfs	p.K1390fs	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1390	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CAGAACTCACTTGGCCTCCTC	0.617													---	---	---								-	23887419	-	-	23887419	7	5	285	1	0	1	0	1	0	0	0	0	10092	1623	56	0	1682	0	MYH7	14	23887419	Frame_Shift_Del	DEL	T	TCGA-DQ-5629-01A-01D-1870-08	3194799	23887419	83462121	267	53122											
NPAS3	64067	broad.mit.edu	37	chr14	34269385	34269385	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccagcgcgtcgagcccaggCggcctggacgcgggcctggt	4	5	17	15	6	0	0	0	0	0	0	2	2	1	1	4	5	2	0	4	5	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:34269385C>A	uc001wru.2	+	12	1936	c.1872C>A	c.(1870-1872)GGC>GGA	p.G624G	NPAS3_uc001wrs.2_Silent_p.G611G|NPAS3_uc001wrt.2_Silent_p.G592G|NPAS3_uc001wrv.2_Silent_p.G594G	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	624					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CGAGCCCAGGCGGCCTGGACG	0.672													17	6					3.52763e-06	3.81526e-06	1	0	A	34269385	A	A	34269385	2	1	285	1	0	0	0	0	0	0	0	1	10618	755	27	3		3	NPAS3	14	34269385	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	10381966	34269385	73080155	268	53123											
BAZ1A	11177	broad.mit.edu	37	chr14	35243604	35243604	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaatctctcagccttagttCaagttgcttttctgcacaca	11	14	5	11	0	4	0	2	0	2	0	5	0	4	0	1	0	3	4	1	0	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:35243604C>T	uc001wsk.2	-	19	3494	c.2926G>A	c.(2926-2928)GAA>AAA	p.E976K	BAZ1A_uc001wsl.2_Missense_Mutation_p.E944K	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	976					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		AGCCTTAGTTCAAGTTGCTTT	0.378													10	40					0	0	0	0	T	35243604	T	T	35243604	3	4	285	1	0	0	0	0	1	0	0	0	1331	835	29	2	1780	2	BAZ1A	14	35243604	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	974219	35243604	72105936	269	53124											
LRFN5	145581	broad.mit.edu	37	chr14	42356760	42356760	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacactgaggtgcaaagccaGgggagaccctgagcctgcaa	13	4	13	11	0	0	3	0	2	0	1	0	4	0	3	3	3	5	2	3	3	3	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:42356760G>T	uc001wvm.2	+	3	2130	c.932G>T	c.(931-933)AGG>ATG	p.R311M	LRFN5_uc010ana.2_Missense_Mutation_p.R311M	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	311	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGCAAAGCCAGGGGAGACCCT	0.468										HNSCC(30;0.082)			42	47					3.09479e-21	4.06924e-21	1	0	T	42356760	T	T	42356760	3	4	285	1	0	0	0	0	1	0	0	0	8991	1000	35	4	934	4	LRFN5	14	42356760	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	7113156	42356760	64992780	270	53125											
FAM179B	23116	broad.mit.edu	37	chr14	45537659	45537659	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttaaatctcgacttcatgaTtctaatagtaaagtaaatct	15	16	4	6	1	4	1	1	1	3	0	5	2	4	1	0	0	0	2	0	0	8	8			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:45537659T>A	uc001wvv.2	+	17	4832	c.4623T>A	c.(4621-4623)GAT>GAA	p.D1541E	FAM179B_uc001wvw.2_Missense_Mutation_p.D1594E|FAM179B_uc010anc.2_RNA	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	1541	HEAT 5.						binding			skin(2)|upper_aerodigestive_tract(1)	3						GACTTCATGATTCTAATAGTA	0.279													9	35					0	0	0	0	A	45537659	A	A	45537659	3	1	285	1	0	0	0	0	1	0	0	0	5534	1490	52	5	4689	5	FAM179B	14	45537659	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	3180899	45537659	61811881	271	53126											
MDGA2	161357	broad.mit.edu	37	chr14	47389219	47389219	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagttagatttctcacctgcCtgatgcccaaccggtatgca	9	11	8	13	1	1	2	1	1	1	1	2	2	1	2	4	1	4	3	4	1	3	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:47389219C>T	uc001wwj.3	-	10	2223	c.2027G>A	c.(2026-2028)AGG>AAG	p.R676K	MDGA2_uc001wwi.3_Missense_Mutation_p.R447K|MDGA2_uc010ani.2_Missense_Mutation_p.R236K	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	676					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TCTCACCTGCCTGATGCCCAA	0.413													10	27					0	0	0	0	T	47389219	T	T	47389219	3	4	285	1	0	0	0	0	1	0	0	0	9460	681	24	4	875	4	MDGA2	14	47389219	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1851560	47389219	59960321	272	53127											
SAV1	60485	broad.mit.edu	37	chr14	51132094	51132094	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttccgttacaaatgactgaGaagaaccatactctctaggg	13	10	8	10	1	1	3	0	2	1	2	3	4	2	3	2	1	3	1	2	1	6	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:51132094G>A	uc001wyg.1	-	3	499	c.338C>T	c.(337-339)TCT>TTT	p.S113F	SAV1_uc001wyh.1_Missense_Mutation_p.S113F	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	WW45 protein	113					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)	1	all_epithelial(31;0.000611)|Breast(41;0.0333)					AAATGACTGAGAAGAACCATA	0.388													13	13					0	0	0	0	A	51132094	A	A	51132094	3	1	285	1	0	0	0	0	1	0	0	0	13921	942	33	2	829	2	SAV1	14	51132094	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	3742875	51132094	56217446	273	53128											
NID2	22795	broad.mit.edu	37	chr14	52481978	52481978	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agcgctcacagatggtcgggGgcctctgggtgggctctgag	5	8	18	10	2	3	2	1	1	2	1	4	2	3	2	1	5	1	2	1	5	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:52481978G>T	uc001wzo.2	-	15	3278	c.3044C>A	c.(3043-3045)CCC>CAC	p.P1015H	NID2_uc010tqs.1_Missense_Mutation_p.P967H|NID2_uc010tqt.1_Missense_Mutation_p.P1015H|NID2_uc001wzp.2_Missense_Mutation_p.P1015H	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1015						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GATGGTCGGGGGCCTCTGGGT	0.582													20	30					4.35082e-09	4.90555e-09	1	0	T	52481978	T	T	52481978	3	4	285	1	0	0	0	0	1	0	0	0	10469	1232	43	4	1115	4	NID2	14	52481978	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1349884	52481978	54867562	274	53129											
NID2	22795	broad.mit.edu	37	chr14	52509605	52509605	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgccgggagcattgtctgtGgttgtgttcacaggtttcct	5	15	13	8	1	2	0	1	0	1	0	3	1	3	1	2	3	2	4	2	3	0	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:52509605G>C	uc001wzo.2	-	6	1708	c.1474C>G	c.(1474-1476)CAC>GAC	p.H492D	NID2_uc010tqs.1_Missense_Mutation_p.H492D|NID2_uc010tqt.1_Missense_Mutation_p.H492D|NID2_uc001wzp.2_Missense_Mutation_p.H492D	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	492	EGF-like 1.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CATTGTCTGTGGTTGTGTTCA	0.458													30	46					0	0	0	0	C	52509605	C	C	52509605	3	2	285	1	0	0	0	0	1	0	0	0	10469	1348	47	4	2721	4	NID2	14	52509605	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	27627	52509605	54839935	275	53130											
C14orf37	145407	broad.mit.edu	37	chr14	58598275	58598275	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atatgaggcagctgtattaaCacgagtaatagatggaacaa	17	9	10	5	1	0	2	0	1	0	1	0	4	0	3	0	2	3	4	0	2	7	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:58598275C>A	uc001xdc.2	-	4	1897	c.1786G>T	c.(1786-1788)GTT>TTT	p.V596F	C14orf37_uc010tro.1_Missense_Mutation_p.V634F|C14orf37_uc001xdd.2_Missense_Mutation_p.V596F|C14orf37_uc001xde.2_Missense_Mutation_p.V596F	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	596	Extracellular (Potential).					integral to membrane	binding				0						GCTGTATTAACACGAGTAATA	0.478													28	31					2.65835e-16	3.32109e-16	1	0	A	58598275	A	A	58598275	3	1	285	1	0	0	0	0	1	0	0	0	1777	478	17	4	558	4	C14orf37	14	58598275	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	6088670	58598275	48751265	276	53131											
DACT1	51339	broad.mit.edu	37	chr14	59113678	59113678	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accagcgactctgaagaaagCgggggcttaatttggtccca	11	8	12	10	2	1	2	0	1	1	1	2	3	2	2	2	3	2	1	2	3	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:59113678C>T	uc001xdw.2	+	4	2501	c.2337C>T	c.(2335-2337)AGC>AGT	p.S779S	DACT1_uc010trv.1_Silent_p.S498S|DACT1_uc001xdx.2_Silent_p.S742S|DACT1_uc010trw.1_Silent_p.S498S	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	779					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CTGAAGAAAGCGGGGGCTTAA	0.542													25	87					0	0	0	0	T	59113678	T	T	59113678	2	4	285	1	0	0	0	0	0	0	0	1	4239	767	27	1		1	DACT1	14	59113678	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	515403	59113678	48235862	277	53132											
MPP5	64398	broad.mit.edu	37	chr14	67768785	67768786	+	Missense_Mutation	DNP	GG	TT	TT																															aaagtattggccagtatggaGgagaaactgtaaaaatagtt																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:67768785_67768786GG>TT	uc001xjc.2	+	6	1217_1218	c.751_752GG>TT	c.(751-753)GGA>TTA	p.G251L	MPP5_uc001xjd.2_Missense_Mutation_p.G217L|ATP6V1D_uc001xje.2_Intron	NM_022474	NP_071919	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5	251					tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			ovary(1)	1				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		CCAGTATGGAGGAGAAACTGTA	0.416													36	36					0	0	0	0	TT	67768786	TT	TT	67768785	3	4	285	1	0	0	0	0	1	0	0	0	9790	1001	35	4	765	4	MPP5	14	67768785	Missense_Mutation	DNP	GG	TCGA-DQ-5629-01A-01D-1870-08	8655107	67768785	39580755	278	53133											
RDH12	145226	broad.mit.edu	37	chr14	68192857	68192857	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atggctttgaaacccacctgGgagtcaaccacctgggtaag	11	8	11	11	0	1	1	1	1	0	0	1	2	1	2	4	3	2	2	4	3	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:68192857G>A	uc001xjz.3	+	6	757	c.433G>A	c.(433-435)GGA>AGA	p.G145R		NM_152443	NP_689656	Q96NR8	RDH12_HUMAN	retinol dehydrogenase 12	145			G -> E (in retinal dystrophy; exhibits a profound loss of catalytic activity).		photoreceptor cell maintenance|response to stimulus|retinol metabolic process	intracellular	binding|retinol dehydrogenase activity			ovary(1)	1				all cancers(60;0.000704)|OV - Ovarian serous cystadenocarcinoma(108;0.00161)|BRCA - Breast invasive adenocarcinoma(234;0.00953)	Vitamin A(DB00162)	AACCCACCTGGGAGTCAACCA	0.433													80	90					0	0	0	0	A	68192857	A	A	68192857	3	1	285	1	0	0	0	0	1	0	0	0	13256	1233	43	4	447	4	RDH12	14	68192857	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	424072	68192857	39156683	279	53134											
COX16	51241	broad.mit.edu	37	chr14	70795900	70795900	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acataccgtacctcatattcCgactctaaagatattttatt	13	15	3	10	2	2	1	1	0	1	1	3	2	3	1	3	0	2	1	3	0	7	9			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:70795900C>T	uc001xmb.2	-	3	335	c.195G>A	c.(193-195)TCG>TCA	p.S65S		NM_016468	NP_057552	Q9P0S2	COX16_HUMAN	COX16 cytochrome c oxidase assembly homolog	65						integral to membrane|mitochondrial membrane					0						CCTCATATTCCGACTCTAAAG	0.294													20	26					0	0	0	0	T	70795900	T	T	70795900	2	4	285	1	0	0	0	0	0	0	0	1	3780	639	23	1		1	COX16	14	70795900	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2603043	70795900	36553640	280	53135											
RGS6	9628	broad.mit.edu	37	chr14	72431525	72431525	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caggatggctcaaggatccgGggatcaaagagcagtggggg	11	5	18	7	1	2	1	2	0	0	1	3	4	3	4	1	7	1	2	1	7	2	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:72431525G>A	uc001xna.3	+	2	540	c.17G>A	c.(16-18)GGG>GAG	p.G6E	RGS6_uc010ttn.1_Missense_Mutation_p.G6E|RGS6_uc001xmx.3_Missense_Mutation_p.G6E|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.G6E	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	6					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CAAGGATCCGGGGATCAAAGA	0.463													27	76					0	0	0	0	A	72431525	A	A	72431525	3	1	285	1	0	0	0	0	1	0	0	0	13374	1232	43	4	19	4	RGS6	14	72431525	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1635625	72431525	34918015	281	53136											
NRXN3	9369	broad.mit.edu	37	chr14	79111601	79111601	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taacggcctcatcctgcacaCgggcaagtcggctgactatg	9	8	11	13	3	1	1	1	1	0	0	3	1	2	1	2	3	2	3	2	3	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:79111601C>T	uc001xun.2	+	2	268	c.-223C>T	c.(-225--221)CACGG>CATGG		NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.T60M	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor						axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		ATCCTGCACACGGGCAAGTCG	0.562													5	32					0	0	0	0	T	79111601	T	T	79111601	1	4	285	1	0	0	0	0	0	0	0	0	10721	551	19	1		1	NRXN3	14	79111601	Translation_Start_Site	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	6680076	79111601	28237939	282	53137											
NRXN3	9369	broad.mit.edu	37	chr14	79181346	79181346	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaatgctgcgggtgtcaaGtcctcctgttcacggatgag	8	10	13	10	2	2	2	2	1	0	1	4	3	4	3	2	2	2	2	2	2	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:79181346G>T	uc001xun.2	+	5	1280	c.789G>T	c.(787-789)AAG>AAT	p.K263N	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.K397N	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	636	Extracellular (Potential).|Laminin G-like 3.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CGGGTGTCAAGTCCTCCTGTT	0.547													29	21					1.06801e-11	1.26423e-11	1	0	T	79181346	T	T	79181346	3	4	285	1	0	0	0	0	1	0	0	0	10721	1020	36	4	799	4	NRXN3	14	79181346	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	69745	79181346	28168194	283	53138											
KCNK10	54207	broad.mit.edu	37	chr14	88707125	88707125	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgttgttggaagagtttcCtattggactgactcccgcat	7	14	11	9	1	0	2	0	1	0	1	2	4	2	4	2	2	0	5	2	2	2	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:88707125C>A	uc001xwo.2	-	3	884	c.427G>T	c.(427-429)GGA>TGA	p.G143*	KCNK10_uc001xwm.2_Nonsense_Mutation_p.G148*|KCNK10_uc001xwn.2_Nonsense_Mutation_p.G148*	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	143					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						GAAGAGTTTCCTATTGGACTG	0.418													28	87					2.79863e-10	3.2699e-10	1	0	A	88707125	A	A	88707125	4	1	285	1	0	0	0	0	0	1	0	0	8098	690	24	4	1209	4	KCNK10	14	88707125	Nonsense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	9525779	88707125	18642415	284	53139											
CCDC88C	440193	broad.mit.edu	37	chr14	91739649	91739649	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaggccaggctgaaggcccGgctcaaggaggcactgcggc	8	4	17	12	2	1	2	1	2	0	0	1	3	1	3	2	7	1	3	2	7	2	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:91739649G>A	uc010aty.2	-	30	5506	c.5407C>T	c.(5407-5409)CGG>TGG	p.R1803W	CCDC88C_uc001xzj.2_Missense_Mutation_p.R327W|CCDC88C_uc001xzi.2_Missense_Mutation_p.R253W	NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1803				Missing (in Ref. 3; AAH35914).	microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				CTGAAGGCCCGGCTCAAGGAG	0.697													3	7					0	0	0	0	A	91739649	A	A	91739649	3	1	285	1	0	0	0	0	1	0	0	0	2878	1115	39	1	683	1	CCDC88C	14	91739649	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	3032524	91739649	15609891	285	53140											
FAM181A	90050	broad.mit.edu	37	chr14	94391643	94391643	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttagaagagagaagatcttCtggagagaggaatgatgcag	15	8	14	4	0	2	6	0	1	2	5	2	10	2	8	0	2	1	1	0	2	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:94391643C>A	uc001ybz.1	+	2	333	c.26C>A	c.(25-27)TCT>TAT	p.S9Y	C14orf86_uc001yby.2_Intron|FAM181A_uc010aus.1_5'Flank|FAM181A_uc001yca.1_5'Flank	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	9											0						AGAAGATCTTCTGGAGAGAGG	0.557													18	45					8.34094e-07	9.10838e-07	1	0	A	94391643	A	A	94391643	3	1	285	1	0	0	0	0	1	0	0	0	5536	913	32	2	28	2	FAM181A	14	94391643	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2651994	94391643	12957897	286	53141											
DLK1	8788	broad.mit.edu	37	chr14	101198399	101198399	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgttcgggcctgctcctcgGccccctgtgccaacaacagg	6	8	11	16	2	0	0	0	0	0	0	3	0	1	0	5	3	4	2	5	3	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:101198399G>A	uc001yhs.3	+	4	436	c.283G>A	c.(283-285)GCC>ACC	p.A95T	DLK1_uc001yhu.3_Missense_Mutation_p.A95T	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	95	Extracellular (Potential).|EGF-like 3.				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				CTGCTCCTCGGCCCCCTGTGC	0.597													22	27					0	0	0	0	A	101198399	A	A	101198399	3	1	285	1	0	0	0	0	1	0	0	0	4586	1203	42	4	297	4	DLK1	14	101198399	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	6806756	101198399	6151141	287	53142											
CDCA4	55038	broad.mit.edu	37	chr14	105477874	105477874	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcctgtgctgaggtgacTgggcaaaggtcagaaactgg	9	8	17	7	0	1	3	1	2	0	1	1	3	1	3	1	5	3	2	1	5	2	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr14:105477874T>A	uc001yqa.2	-	2	489	c.393A>T	c.(391-393)CCA>CCT	p.P131P	CDCA4_uc001yqb.2_Silent_p.P131P	NM_145701	NP_663747	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	131						nucleus				ovary(1)	1		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		CTGAGGTGACTGGGCAAAGGT	0.607													20	44					0	0	0	0	A	105477874	A	A	105477874	2	1	285	1	0	0	0	0	0	0	0	1	3103	1567	55	5		5	CDCA4	14	105477874	Silent	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	4279475	105477874	1871666	288	53143											
MAGEL2	54551	broad.mit.edu	37	chr15	23890312	23890312	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcagttgcctggggggcagCtgctgtagccatcaggaagg	7	7	18	9	0	1	0	1	0	0	0	1	1	1	1	2	6	4	6	2	6	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:23890312C>A	uc001ywj.3	-	1	864	c.769G>T	c.(769-771)GCT>TCT	p.A257S		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TGGGGGGCAGCTGCTGTAGCC	0.627													17	53					1.02788e-11	1.22315e-11	1	0	A	23890312	A	A	23890312	3	1	285	1	0	0	0	0	1	0	0	0	9242	797	28	4	1175	4	MAGEL2	15	23890312	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		23890312	78641080	289	53144											
C15orf2	23742	broad.mit.edu	37	chr15	24921822	24921822	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagccagccgttggctgcTccctgctgcagcagaagttg	6	9	13	13	1	0	2	0	1	0	1	1	2	1	2	3	1	6	7	3	1	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:24921822T>C	uc001ywo.2	+	1	1282	c.808T>C	c.(808-810)TCC>CCC	p.S270P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	270					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CGTTGGCTGCTCCCTGCTGCA	0.637													22	17					0	0	0	0	C	24921822	C	C	24921822	3	2	285	1	0	0	0	0	1	0	0	0	1790	1551	54	5	810	5	C15orf2	15	24921822	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	1031510	24921822	77609570	290	53145											
C15orf2	23742	broad.mit.edu	37	chr15	24922763	24922763	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatggatactactgccccAtctcaggttgttattttcac	10	15	6	10	0	2	0	2	0	1	0	3	1	2	1	2	2	3	2	2	2	5	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:24922763A>G	uc001ywo.2	+	1	2223	c.1749A>G	c.(1747-1749)CCA>CCG	p.P583P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	583					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CTACTGCCCCATCTCAGGTTG	0.488													27	70					0	0	0	0	G	24922763	G	G	24922763	2	3	285	1	0	0	0	0	0	0	0	1	1790	204	8	5		5	C15orf2	15	24922763	Silent	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	941	24922763	77608629	291	53146											
GABRA5	2558	broad.mit.edu	37	chr15	27159966	27159966	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagcttgaccatctctgcaGagtgccccatgcagcttgag	8	10	10	13	0	2	3	1	2	1	1	3	3	2	3	3	0	5	4	3	0	0	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:27159966G>T	uc001zbd.1	+	8	853	c.514G>T	c.(514-516)GAG>TAG	p.E172*	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	172	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CATCTCTGCAGAGTGCCCCAT	0.478													7	41					0.000157383	0.000165069	1	0	T	27159966	T	T	27159966	4	4	285	1	0	0	0	0	0	1	0	0	6198	943	33	2	532	2	GABRA5	15	27159966	Nonsense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2237203	27159966	75371426	292	53147											
OCA2	4948	broad.mit.edu	37	chr15	28090152	28090152	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tatccatgctgttctgcaatCcctgcacacacgacgtttgc	8	12	7	14	2	1	0	0	0	1	0	3	1	3	0	2	0	4	5	2	0	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:28090152C>G	uc001zbh.3	-	23	2495	c.2385G>C	c.(2383-2385)GGG>GGC	p.G795G	OCA2_uc010ayv.2_Silent_p.G771G	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	795	Extracellular (Potential).		G -> R (in OCA2).		eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GTTCTGCAATCCCTGCACACA	0.403									Oculocutaneous_Albinism				10	59					0	0	0	0	G	28090152	G	G	28090152	2	3	285	1	0	0	0	0	0	0	0	1	10869	842	30	2		2	OCA2	15	28090152	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	930186	28090152	74441240	293	53148											
SLC24A5	283652	broad.mit.edu	37	chr15	48434324	48434324	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaactgcatttataaatGgatcagctcctgcagaagta	15	12	7	7	0	1	1	1	0	0	1	2	2	2	2	1	1	4	4	1	1	7	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:48434324G>T	uc001zwe.2	+	9	1352	c.1279G>T	c.(1279-1281)GGA>TGA	p.G427*	SLC24A5_uc010bel.2_Nonsense_Mutation_p.G367*|MYEF2_uc001zwg.3_3'UTR|MYEF2_uc001zwh.3_3'UTR|MYEF2_uc001zwi.3_3'UTR|MYEF2_uc001zwj.3_3'UTR|SLC24A5_uc001zwk.2_Nonsense_Mutation_p.G58*	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	427	Cytoplasmic (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		ATTTATAAATGGATCAGCTCC	0.363													53	62					5.13769e-22	6.81499e-22	1	0	T	48434324	T	T	48434324	4	4	285	1	0	0	0	0	0	1	0	0	14533	1349	47	4	1313	4	SLC24A5	15	48434324	Nonsense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	20344172	48434324	54097068	294	53149											
FBN1	2200	broad.mit.edu	37	chr15	48776017	48776017	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgtcttctttgcttacctAcacaagtcttcatgtcttca	7	18	4	12	0	7	0	2	0	5	0	7	0	7	0	1	0	3	1	1	0	3	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:48776017A>G	uc001zwx.1	-	31	4164	c.3836T>C	c.(3835-3837)GTA>GCA	p.V1279A		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1279	EGF-like 20; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TTGCTTACCTACACAAGTCTT	0.383													14	45					0	0	0	0	G	48776017	G	G	48776017	3	3	285	1	0	0	0	0	1	0	0	0	5734	391	14	5	4923	5	FBN1	15	48776017	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	341693	48776017	53755375	295	53150											
C15orf33	196951	broad.mit.edu	37	chr15	49833958	49833958	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcgattctggaaatgcttCatggaacgttgcatatatgg	11	13	10	7	2	2	0	1	0	1	0	3	3	2	2	0	3	3	3	0	3	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:49833958C>A	uc001zxl.2	-	10	1087	c.793G>T	c.(793-795)GAA>TAA	p.E265*	C15orf33_uc001zxm.2_Nonsense_Mutation_p.E231*	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	265										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		GGAAATGCTTCATGGAACGTT	0.254													24	95					1.17739e-12	1.41225e-12	1	0	A	49833958	A	A	49833958	4	1	285	1	0	0	0	0	0	1	0	0	1797	835	29	2	761	2	C15orf33	15	49833958	Nonsense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1057941	49833958	52697434	296	53151											
C15orf33	196951	broad.mit.edu	37	chr15	49868948	49868948	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttacatacatcaaaattaTgggcttttaaaataaaaaga	20	13	4	4	0	1	1	1	0	0	1	1	1	1	1	0	1	2	1	0	1	10	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:49868948T>C	uc001zxl.2	-	7	830	c.536A>G	c.(535-537)CAT>CGT	p.H179R	C15orf33_uc001zxm.2_Missense_Mutation_p.H179R	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	179										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		ATCAAAATTATGGGCTTTTAA	0.299													23	10					0	0	0	0	C	49868948	C	C	49868948	3	2	285	1	0	0	0	0	1	0	0	0	1797	1464	51	5	1030	5	C15orf33	15	49868948	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	34990	49868948	52662444	297	53152											
VPS13C	54832	broad.mit.edu	37	chr15	62182498	62182498	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcagtgctttggaaaccaaGgcaacatcatcggtgaaaag	14	8	11	8	1	1	1	1	1	0	0	2	2	1	2	1	3	4	3	1	3	5	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:62182498G>A	uc002agz.2	-	67	9281	c.9207C>T	c.(9205-9207)GCC>GCT	p.A3069A	VPS13C_uc002aha.2_Silent_p.A3026A|VPS13C_uc002ahb.1_Silent_p.A3069A|VPS13C_uc002ahc.1_Silent_p.A3026A	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3069					protein localization					ovary(2)	2						TGGAAACCAAGGCAACATCAT	0.438													10	55					0	0	0	0	A	62182498	A	A	62182498	2	1	285	1	0	0	0	0	0	0	0	1	17259	987	35	4		4	VPS13C	15	62182498	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	12313550	62182498	40348894	298	53153											
DENND4A	10260	broad.mit.edu	37	chr15	65968863	65968863	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagtagcactggtctcttgaGaggagataggtccttccaac	11	10	11	9	0	1	2	0	1	1	2	4	4	3	2	2	3	2	2	2	3	4	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:65968863G>A	uc002aph.2	-	23	4535	c.4157C>T	c.(4156-4158)TCT>TTT	p.S1386F	DENND4A_uc002api.2_Missense_Mutation_p.S1429F	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GGTCTCTTGAGAGGAGATAGG	0.458													20	13					0	0	0	0	A	65968863	A	A	65968863	3	1	285	1	0	0	0	0	1	0	0	0	4455	942	33	2	1474	2	DENND4A	15	65968863	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	3786365	65968863	36562529	299	53154											
KIAA1199	57214	broad.mit.edu	37	chr15	81241181	81241181	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaggcagcttccggcccatCtgggtgacactggacactga	10	7	12	12	1	1	2	0	2	1	0	2	3	2	3	2	4	1	2	2	4	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:81241181C>G	uc002bfw.1	+	29	4262	c.4002C>G	c.(4000-4002)ATC>ATG	p.I1334M	KIAA1199_uc010unn.1_Missense_Mutation_p.I1334M|MESDC2_uc002bfx.2_RNA|MESDC2_uc010uno.1_RNA	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	1334										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TCCGGCCCATCTGGGTGACAC	0.532													44	118					0	0	0	0	G	81241181	G	G	81241181	3	3	285	1	0	0	0	0	1	0	0	0	8252	903	32	2	4112	2	KIAA1199	15	81241181	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	15272318	81241181	21290211	300	53155											
NTRK3	4916	broad.mit.edu	37	chr15	88420304	88420304	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgtacacctctttggggcaGactcggggccgctccaaaac	8	8	11	14	3	1	1	0	0	1	1	4	1	2	1	3	4	2	3	3	4	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:88420304G>A	uc002bme.1	-	19	2544	c.2382C>T	c.(2380-2382)GTC>GTT	p.V794V	NTRK3_uc002bmh.2_Silent_p.V772V|NTRK3_uc002bmf.1_Silent_p.V780V	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	794	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTTTGGGGCAGACTCGGGGCC	0.522			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			7	42					0	0	0	0	A	88420304	A	A	88420304	2	1	285	1	0	0	0	0	0	0	0	1	10762	929	33	2		2	NTRK3	15	88420304	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	7179123	88420304	14111088	301	53156											
ACAN	176	broad.mit.edu	37	chr15	89382097	89382097	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctgctggtggccactgaaGggcgcgtgcgggtcaacagt	6	8	17	10	3	1	1	1	1	0	0	1	1	1	1	1	4	4	2	1	4	2	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:89382097G>T	uc010upo.1	+	3	648	c.274G>T	c.(274-276)GGG>TGG	p.G92W	ACAN_uc002bmx.2_Missense_Mutation_p.G92W|ACAN_uc010upp.1_Missense_Mutation_p.G92W|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	92					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGCCACTGAAGGGCGCGTGCG	0.632													7	86					1.06961e-07	1.18525e-07	1	0	T	89382097	T	T	89382097	3	4	285	1	0	0	0	0	1	0	0	0	117	1000	35	4	280	4	ACAN	15	89382097	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	961793	89382097	13149295	302	53157											
FANCI	55215	broad.mit.edu	37	chr15	89804006	89804006	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatatacacttgttgtatcCagttggtggaatcgggggat	10	13	13	5	1	0	1	0	0	0	1	2	3	1	3	1	4	1	3	1	4	4	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:89804006C>G	uc010bnp.1	+	4	310	c.220C>G	c.(220-222)CAG>GAG	p.Q74E	FANCI_uc002bnm.1_Missense_Mutation_p.Q74E|FANCI_uc002bnn.1_RNA|FANCI_uc002bno.2_Missense_Mutation_p.Q74E|FANCI_uc002bnp.1_5'Flank	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	74					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TTGTTGTATCCAGTTGGTGGA	0.423								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				16	83					0	0	0	0	G	89804006	G	G	89804006	3	3	285	1	0	0	0	0	1	0	0	0	5701	595	21	4	230	4	FANCI	15	89804006	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	421909	89804006	12727386	303	53158											
RHCG	51458	broad.mit.edu	37	chr15	90020344	90020344	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacccatcagggccatggcCagggtcaccaagagaccata	12	4	10	15	0	2	1	2	0	0	1	2	2	2	1	6	3	0	0	6	3	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:90020344C>T	uc002bnz.2	-	8	1230	c.1206G>A	c.(1204-1206)CTG>CTA	p.L402L	RHCG_uc002bny.2_Silent_p.L173L|RHCG_uc002boa.2_RNA	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	402	Helical; (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					GGGCCATGGCCAGGGTCACCA	0.567													27	88					0	0	0	0	T	90020344	T	T	90020344	2	4	285	1	0	0	0	0	0	0	0	1	13391	581	21	4		4	RHCG	15	90020344	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	216338	90020344	12511048	304	53159											
PEX11A	8800	broad.mit.edu	37	chr15	90229763	90229763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatctaagcaacatgcatGtgtactgagtggctctgaaa	14	11	9	7	0	2	2	0	2	2	0	2	2	2	2	0	1	4	4	0	1	6	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:90229763G>A	uc002boi.2	-	2	166	c.71C>T	c.(70-72)ACA>ATA	p.T24I	PEX11A_uc010upy.1_Intron	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	24	Cytoplasmic (Potential).				cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CAACATGCATGTGTACTGAGT	0.378													55	48					0	0	0	0	A	90229763	A	A	90229763	3	1	285	1	0	0	0	0	1	0	0	0	11792	1377	48	4	680	4	PEX11A	15	90229763	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	209419	90229763	12301629	305	53160											
VPS33B	26276	broad.mit.edu	37	chr15	91546342	91546342	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tactgtgttttcagagatcgGtaatccttggggatcaaacc	10	13	10	8	1	2	1	2	0	0	1	4	3	3	2	2	3	2	2	2	3	3	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr15:91546342G>T	uc002bqp.1	-	17	1599	c.1245C>A	c.(1243-1245)TAC>TAA	p.Y415*	VPS33B_uc002bqq.1_Nonsense_Mutation_p.Y324*|VPS33B_uc010uqu.1_Nonsense_Mutation_p.Y388*	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	415					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					TCAGAGATCGGTAATCCTTGG	0.458													73	60					6.86016e-32	9.54917e-32	1	0	T	91546342	T	T	91546342	4	4	285	1	0	0	0	0	0	1	0	0	17270	1256	44	4	636	4	VPS33B	15	91546342	Nonsense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1316579	91546342	10985050	306	53161											
C16orf71	146562	broad.mit.edu	37	chr16	4797521	4797521	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctctgtgccaaggggcaGagcgcccaggctcgactccc	8	5	13	15	2	1	1	0	0	1	1	3	2	2	1	3	3	3	3	3	3	2	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:4797521G>C	uc002cxn.2	+	9	1920	c.1458G>C	c.(1456-1458)CAG>CAC	p.Q486H		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	486										central_nervous_system(1)	1						CCAAGGGGCAGAGCGCCCAGG	0.667													13	15					0	0	0	0	C	4797521	C	C	4797521	3	2	285	1	0	0	0	0	1	0	0	0	1836	933	33	2	1488	2	C16orf71	16	4797521	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08		4797521	85557232	307	53162											
RSL1D1	26156	broad.mit.edu	37	chr16	11935671	11935671	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaacaggagtttcacgctctCccacttctgaaacaaagaaa	16	8	6	11	1	3	2	1	1	2	1	4	3	3	3	1	1	2	2	1	1	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:11935671C>A	uc002dbp.1	-	7	809	c.736G>T	c.(736-738)GAG>TAG	p.E246*	RSL1D1_uc010buv.1_Nonsense_Mutation_p.E245*|RSL1D1_uc010uyw.1_Nonsense_Mutation_p.E26*|RSL1D1_uc010buw.2_RNA	NM_015659	NP_056474	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	246					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						TTCACGCTCTCCCACTTCTGA	0.393													17	24					9.16793e-09	1.02599e-08	1	0	A	11935671	A	A	11935671	4	1	285	1	0	0	0	0	0	1	0	0	13765	864	30	2	748	2	RSL1D1	16	11935671	Nonsense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	7138150	11935671	78419082	308	53163											
ABCC1	4363	broad.mit.edu	37	chr16	16177363	16177363	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcctcccagacctggaaatCctgcccagtggggatcggac	8	7	11	15	1	0	1	0	0	0	1	4	4	3	4	5	4	1	0	5	4	1	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:16177363C>T	uc010bvi.2	+	17	2431	c.2256C>T	c.(2254-2256)ATC>ATT	p.I752I	ABCC1_uc010bvj.2_Intron|ABCC1_uc010bvk.2_Silent_p.I752I|ABCC1_uc010bvl.2_Silent_p.I752I|ABCC1_uc010bvm.2_Intron|ABCC1_uc002del.3_Silent_p.I636I	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	752	ABC transporter 1.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ACCTGGAAATCCTGCCCAGTG	0.517													11	60					0	0	0	0	T	16177363	T	T	16177363	2	4	285	1	0	0	0	0	0	0	0	1	49	845	30	2		2	ABCC1	16	16177363	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	4241692	16177363	74177390	309	53164											
ACSM5	54988	broad.mit.edu	37	chr16	20451218	20451218	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcatgtgaaaagggtgactGctccatacaaataccccagg	14	7	10	10	0	0	2	0	2	0	0	1	2	1	2	3	2	4	2	3	2	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:20451218G>A	uc002dhe.2	+	13	1780	c.1633G>A	c.(1633-1635)GCT>ACT	p.A545T		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	545					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						AAGGGTGACTGCTCCATACAA	0.468													21	56					0	0	0	0	A	20451218	A	A	20451218	3	1	285	1	0	0	0	0	1	0	0	0	187	1319	46	4	1679	4	ACSM5	16	20451218	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4273855	20451218	69903535	310	53165											
KIAA0556	23247	broad.mit.edu	37	chr16	27752188	27752188	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctagtgggaggaggggctCaaggaaggatgctggcagca	10	6	19	6	0	1	0	1	0	0	0	1	4	1	4	0	7	3	5	0	7	3	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:27752188C>G	uc002dow.2	+	15	2594	c.2570C>G	c.(2569-2571)TCA>TGA	p.S857*		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	857										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						AGGAGGGGCTCAAGGAAGGAT	0.597													9	14					0	0	0	0	G	27752188	G	G	27752188	4	3	285	1	0	0	0	0	0	1	0	0	8222	838	29	2	2628	2	KIAA0556	16	27752188	Nonsense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	7300970	27752188	62602565	311	53166											
NFATC2IP	84901	broad.mit.edu	37	chr16	28967303	28967303	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcttgcttctacagggatCtggacaactctcctctgtcc	6	14	7	14	0	5	0	0	0	5	0	8	2	6	2	2	2	3	1	2	2	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:28967303C>G	uc002dru.2	+	4	598	c.583C>G	c.(583-585)CTG>GTG	p.L195V	uc010vct.1_Intron|NFATC2IP_uc002drt.2_Intron|NFATC2IP_uc002drv.2_Translation_Start_Site|NFATC2IP_uc010vdh.1_5'Flank	NM_032815	NP_116204	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells,	195						cytoplasm|nucleus				ovary(1)	1						CTACAGGGATCTGGACAACTC	0.507													20	55					0	0	0	0	G	28967303	G	G	28967303	3	3	285	1	0	0	0	0	1	0	0	0	10417	912	32	2	597	2	NFATC2IP	16	28967303	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1215115	28967303	61387450	312	53167											
ZNF629	23361	broad.mit.edu	37	chr16	30793202	30793202	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgtgggggtaggggtctcgCcctcaccttcctgatctgtg	3	12	14	12	1	3	1	1	1	2	0	5	1	4	1	3	4	0	1	3	4	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:30793202C>A	uc002dzs.1	-	3	2655	c.2447G>T	c.(2446-2448)GGC>GTC	p.G816V		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	816					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			AGGGGTCTCGCCCTCACCTTC	0.612													68	72					6.25564e-26	8.49787e-26	1	0	A	30793202	A	A	30793202	3	1	285	1	0	0	0	0	1	0	0	0	18120	739	26	4	166	4	ZNF629	16	30793202	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1825899	30793202	59561551	313	53168											
ZNF668	79759	broad.mit.edu	37	chr16	31072519	31072519	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcaagaaggccttgggaCaatgggggcaggtgtagggg	10	6	18	7	0	1	1	1	0	0	1	1	2	1	2	1	7	0	2	1	7	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:31072519C>A	uc010caf.2	-	3	2087	c.1730G>T	c.(1729-1731)TGT>TTT	p.C577F	ZNF668_uc002eao.2_Missense_Mutation_p.C577F	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	577	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						GGCCTTGGGACAATGGGGGCA	0.652													14	60					1.33834e-09	1.52422e-09	1	0	A	31072519	A	A	31072519	3	1	285	1	0	0	0	0	1	0	0	0	18142	478	17	4	133	4	ZNF668	16	31072519	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	279317	31072519	59282234	314	53169											
MYLK3	91807	broad.mit.edu	37	chr16	46771856	46771856	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaggccagtcctgaggttCtcgctgggtgtctcaggagc	5	10	14	12	1	2	1	1	1	2	0	6	2	4	2	3	4	1	2	3	4	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:46771856C>T	uc002eei.3	-	3	884	c.768G>A	c.(766-768)GAG>GAA	p.E256E	MYLK3_uc010vge.1_Intron|MYLK3_uc002eej.1_5'UTR	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	256					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCCTGAGGTTCTCGCTGGGTG	0.647													23	17					0	0	0	0	T	46771856	T	T	46771856	2	4	285	1	0	0	0	0	0	0	0	1	10111	912	32	2		2	MYLK3	16	46771856	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	15699337	46771856	43582897	315	53170											
SLC6A2	6530	broad.mit.edu	37	chr16	55690666	55690666	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacaacggggcggacacgggTccagagcagccccttcgggc	9	3	15	14	4	0	1	0	0	0	1	2	2	1	2	3	5	4	1	3	5	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:55690666T>G	uc002eif.2	+	2	171	c.60T>G	c.(58-60)GGT>GGG	p.G20G	SLC6A2_uc010ccd.2_Silent_p.G20G|SLC6A2_uc002eig.2_Silent_p.G20G|SLC6A2_uc002eih.2_Silent_p.G20G	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	20	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	CGGACACGGGTCCAGAGCAGC	0.697													6	30					0	0	0	0	G	55690666	G	G	55690666	2	3	285	1	0	0	0	0	0	0	0	1	14747	1654	58	5		5	SLC6A2	16	55690666	Silent	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	8918810	55690666	34664087	316	53171											
CNOT1	23019	broad.mit.edu	37	chr16	58594184	58594184	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttttggcataactccaggtgGtggttgtctggccttattca	6	16	11	8	0	2	0	1	0	1	0	3	0	3	0	2	5	1	2	2	5	2	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:58594184G>A	uc002env.2	-	17	2355	c.2062C>T	c.(2062-2064)CCA>TCA	p.P688S	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.P688S|CNOT1_uc002enx.2_Missense_Mutation_p.P688S|CNOT1_uc002enz.1_Missense_Mutation_p.P117S|SNORA50_uc002eoa.1_5'Flank	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	688					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ACTCCAGGTGGTGGTTGTCTG	0.428													29	43					0	0	0	0	A	58594184	A	A	58594184	3	1	285	1	0	0	0	0	1	0	0	0	3632	1261	44	4	5422	4	CNOT1	16	58594184	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2903518	58594184	31760569	317	53172											
CNOT1	23019	broad.mit.edu	37	chr16	58610398	58610398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggccacatcaagtattcgaGacaatttggcctgatcatac	12	10	9	10	1	2	2	2	1	0	1	3	3	2	2	2	2	1	1	2	2	4	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:58610398G>A	uc002env.2	-	14	1966	c.1673C>T	c.(1672-1674)TCT>TTT	p.S558F	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.S558F|CNOT1_uc002enx.2_Missense_Mutation_p.S558F|CNOT1_uc002enz.1_5'UTR	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	558					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AAGTATTCGAGACAATTTGGC	0.408													7	39					0	0	0	0	A	58610398	A	A	58610398	3	1	285	1	0	0	0	0	1	0	0	0	3632	942	33	2	5823	2	CNOT1	16	58610398	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	16214	58610398	31744355	318	53173											
HYDIN	54768	broad.mit.edu	37	chr16	70843905	70843905	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggctgaaattcaaatgagaaCgtgccctggaagagaaaaca	17	6	11	7	1	1	3	1	2	0	2	1	6	1	4	1	2	3	1	1	2	6	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:70843905C>T	uc002ezr.2	-	85	14789	c.14661G>A	c.(14659-14661)ACG>ACA	p.T4887T	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4888										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CAAATGAGAACGTGCCCTGGA	0.488													46	175					0	0	0	0	T	70843905	T	T	70843905	2	4	285	1	0	0	0	0	0	0	0	1	7506	523	19	1		1	HYDIN	16	70843905	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	12233507	70843905	19510848	319	53174											
BCAR1	9564	broad.mit.edu	37	chr16	75276935	75276935	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtcacccttgcggaaggaGagctcatccggggactcggc	8	7	14	12	3	2	1	2	0	0	1	4	4	3	3	2	5	2	1	2	5	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:75276935G>A	uc002fdv.2	-	2	189	c.66C>T	c.(64-66)CTC>CTT	p.L22L	BCAR1_uc010cgu.2_5'UTR|BCAR1_uc010vna.1_Silent_p.L20L|BCAR1_uc010vnb.1_Silent_p.L68L|BCAR1_uc002fdw.2_Silent_p.L22L|BCAR1_uc010vnc.1_Silent_p.L22L|BCAR1_uc010vnd.1_Silent_p.L40L|BCAR1_uc002fdx.2_Silent_p.L40L	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	22	SH3.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGCGGAAGGAGAGCTCATCCG	0.627													14	12					0	0	0	0	A	75276935	A	A	75276935	2	1	285	1	0	0	0	0	0	0	0	1	1350	929	33	2		2	BCAR1	16	75276935	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4433030	75276935	15077818	320	53175											
ZC3H18	124245	broad.mit.edu	37	chr16	88696916	88696916	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcgggaccggaagtcaggtGggagactgggctccccgaag	8	5	17	11	3	1	1	1	0	0	1	3	5	2	3	3	5	0	1	3	5	2	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr16:88696916G>C	uc002fky.2	+	17	2790	c.2590G>C	c.(2590-2592)GGG>CGG	p.G864R	ZC3H18_uc010voz.1_Missense_Mutation_p.G888R|ZC3H18_uc010chw.2_RNA|ZC3H18_uc002fkz.2_Missense_Mutation_p.G134R	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	864						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		GAAGTCAGGTGGGAGACTGGG	0.637													8	24					0	0	0	0	C	88696916	C	C	88696916	3	2	285	1	0	0	0	0	1	0	0	0	17635	1348	47	4	2652	4	ZC3H18	16	88696916	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	13419981	88696916	1657837	321	53176											
TP53	7157	broad.mit.edu	37	chr17	7578461	7578461	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtagatggccatggcgcggaCgcgggtgccgggcgggggtg	4	5	23	9	6	0	1	0	0	0	1	0	2	0	2	2	7	1	1	2	7	1	1	rs121912654		TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:7578461C>A	uc002gim.2	-	5	663	c.469G>T	c.(469-471)GTC>TTC	p.V157F	TP53_uc002gig.1_Missense_Mutation_p.V157F|TP53_uc002gih.2_Missense_Mutation_p.V157F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V25F|TP53_uc010cng.1_Missense_Mutation_p.V25F|TP53_uc002gii.1_Missense_Mutation_p.V25F|TP53_uc010cnh.1_Missense_Mutation_p.V157F|TP53_uc010cni.1_Missense_Mutation_p.V157F|TP53_uc002gij.2_Missense_Mutation_p.V157F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V64F|TP53_uc002gio.2_Missense_Mutation_p.V25F|TP53_uc010vug.1_Missense_Mutation_p.V118F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	157	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> I (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> F (in sporadic cancers; somatic mutation).|V -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V157F(139)|p.V157I(10)|p.V157D(8)|p.V157G(7)|p.0?(7)|p.V157L(6)|p.V157V(5)|p.V157fs*13(3)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.V157fs*22(2)|p.V157fs*24(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.V157A(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.D148fs*23(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.V157fs*25(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCGCGGACGCGGGTGCCG	0.617		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	15					7.88262e-20	1.02748e-19	1	0	A	7578461	A	A	7578461	3	1	285	1	0	0	0	0	1	0	0	0	16448	536	19	3	829	3	TP53	17	7578461	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		7578461	73616749	322	53177											
MYH10	4628	broad.mit.edu	37	chr17	8396258	8396258	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgctggctcagggcctccgCgtccttcagaagcttcttct	4	11	11	15	3	4	1	2	0	2	1	6	1	6	1	3	2	1	3	3	2	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:8396258C>T	uc002gll.2	-	31	4297	c.4201G>A	c.(4201-4203)GCG>ACG	p.A1401T	MYH10_uc002glm.2_Missense_Mutation_p.A1432T|MYH10_uc010cnx.2_Missense_Mutation_p.A1410T	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1401	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						AGGGCCTCCGCGTCCTTCAGA	0.537													39	22					0	0	0	0	T	8396258	T	T	8396258	3	4	285	1	0	0	0	0	1	0	0	0	10083	768	27	1	1773	1	MYH10	17	8396258	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	817797	8396258	72798952	323	53178											
MYH4	4622	broad.mit.edu	37	chr17	10358338	10358338	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgcgcgtgatgagttgagcTagcttttcatctcgcatttc	6	15	11	9	3	2	3	1	3	1	0	4	3	2	3	0	0	3	4	0	0	1	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:10358338T>C	uc002gmn.2	-	21	2466	c.2355A>G	c.(2353-2355)CTA>CTG	p.L785L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	785	IQ.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TGAGTTGAGCTAGCTTTTCAT	0.448													14	39					0	0	0	0	C	10358338	C	C	10358338	2	2	285	1	0	0	0	0	0	0	0	1	10090	1509	53	5		5	MYH4	17	10358338	Silent	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	1962080	10358338	70836872	324	53179											
MPRIP	23164	broad.mit.edu	37	chr17	17077275	17077275	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaactggaggtcctctcggaGcagtactcgcagaagtgcct	9	8	13	11	2	1	1	0	0	1	1	4	4	2	3	2	3	4	3	2	3	3	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:17077275G>A	uc002gqu.1	+	18	2531	c.2475G>A	c.(2473-2475)GAG>GAA	p.E825E	MPRIP_uc002gqv.1_Silent_p.E825E|MPRIP_uc002gqw.1_Silent_p.E580E|MPRIP_uc002gqx.1_Silent_p.E1054E|MPRIP_uc002gqy.1_Silent_p.E1054E|MPRIP_uc010cpl.1_Silent_p.E51E|MPRIP_uc010cpm.1_Silent_p.E51E	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	825	Interaction with PPP1R12A.|Potential.					cytoplasm|cytoskeleton	actin binding				0						TCCTCTCGGAGCAGTACTCGC	0.657													8	21					0	0	0	0	A	17077275	A	A	17077275	2	1	285	1	0	0	0	0	0	0	0	1	9796	962	34	4		4	MPRIP	17	17077275	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	6718937	17077275	64117935	325	53180											
NOS2	4843	broad.mit.edu	37	chr17	26108077	26108077	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtacctgagtgaattccacGttggcagggtcccctctgat	7	11	12	11	1	1	3	0	3	1	0	3	3	3	3	4	3	1	3	4	3	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:26108077G>A	uc002gzu.2	-	8	1113	c.849C>T	c.(847-849)AAC>AAT	p.N283N	NOS2_uc010crh.1_Silent_p.N283N|NOS2_uc010wab.1_Silent_p.N283N	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	283					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TGAATTCCACGTTGGCAGGGT	0.632													25	61					0	0	0	0	A	26108077	A	A	26108077	2	1	285	1	0	0	0	0	0	0	0	1	10597	1136	40	1		1	NOS2	17	26108077	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	9030802	26108077	55087133	326	53181											
MYO18A	399687	broad.mit.edu	37	chr17	27409400	27409400	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccttgttttttgacaaccagGacttgaccccgtcaacacgg	9	11	8	13	2	1	2	1	2	0	0	1	3	1	3	4	2	2	1	4	2	2	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:27409400G>T	uc002hdt.1	-	41	6112	c.5954C>A	c.(5953-5955)TCC>TAC	p.S1985Y	MYO18A_uc010wbc.1_Missense_Mutation_p.S1503Y|MYO18A_uc002hds.2_Missense_Mutation_p.S1512Y|MYO18A_uc010csa.1_Missense_Mutation_p.S1933Y|MYO18A_uc002hdu.1_Missense_Mutation_p.S1970Y	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1985					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TGACAACCAGGACTTGACCCC	0.532													21	50					8.04996e-18	1.02848e-17	1	0	T	27409400	T	T	27409400	3	4	285	1	0	0	0	0	1	0	0	0	10118	1174	41	2	218	2	MYO18A	17	27409400	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1301323	27409400	53785810	327	53182											
LRRC37B	114659	broad.mit.edu	37	chr17	30358450	30358450	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccttggaacatttcaggcctGgcacggaatgcagtttttac	9	12	10	10	1	1	0	1	0	0	0	1	2	1	2	2	4	3	3	2	4	3	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:30358450G>T	uc002hgu.2	+	5	1960	c.1949G>T	c.(1948-1950)TGG>TTG	p.W650L	LRRC37B_uc010wbx.1_Missense_Mutation_p.W568L|LRRC37B_uc010csu.2_Intron	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	650	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TTTCAGGCCTGGCACGGAATG	0.328													11	95					0.000219431	0.000229614	1	0	T	30358450	T	T	30358450	3	4	285	1	0	0	0	0	1	0	0	0	9044	1357	47	4	1967	4	LRRC37B	17	30358450	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2949050	30358450	50836760	328	53183											
SPOP	8405	broad.mit.edu	37	chr17	47696729	47696729	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctttcttcatctaaccctttGgggtttactcgcaaacacct	8	15	5	13	1	3	0	1	0	2	0	4	0	3	0	2	2	3	2	2	2	3	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:47696729G>C	uc010dbk.2	-	5	851	c.219C>G	c.(217-219)CCC>CCG	p.P73P	SPOP_uc002ipb.2_Silent_p.P73P|SPOP_uc002ipc.2_Silent_p.P73P|SPOP_uc002ipd.2_Silent_p.P73P|SPOP_uc002ipe.2_Silent_p.P73P|SPOP_uc002ipf.2_Silent_p.P73P|SPOP_uc002ipg.2_Silent_p.P73P	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein	73	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						CTAACCCTTTGGGGTTTACTC	0.398										Prostate(2;0.17)			15	27					0	0	0	0	C	47696729	C	C	47696729	2	2	285	1	0	0	0	0	0	0	0	1	15150	1335	47	4		4	SPOP	17	47696729	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	17338279	47696729	33498481	329	53184											
KIF2B	84643	broad.mit.edu	37	chr17	51902367	51902367	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgaccgagatccaaaagaAactgaaattattactagctg	16	10	7	8	1	1	4	0	2	1	2	2	5	2	4	2	0	3	1	2	0	7	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:51902367A>T	uc002iua.2	+	1	2129	c.1973A>T	c.(1972-1974)AAA>ATA	p.K658I	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	658	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						ATCCAAAAGAAACTGAAATTA	0.458													30	47					0	0	0	0	T	51902367	T	T	51902367	3	4	285	1	0	0	0	0	1	0	0	0	8337	14	1	5	1975	5	KIF2B	17	51902367	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	4205638	51902367	29292843	330	53185											
TBC1D16	125058	broad.mit.edu	37	chr17	77921571	77921571	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatgggcgccaccaggtccGacatcccttgggaatagccg	9	6	13	13	3	0	1	0	0	0	1	2	3	2	2	5	3	1	0	5	3	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:77921571G>A	uc002jxj.2	-	9	1717	c.1601C>T	c.(1600-1602)TCG>TTG	p.S534L	TBC1D16_uc002jxh.2_Missense_Mutation_p.S172L|TBC1D16_uc002jxi.2_Missense_Mutation_p.S159L|TBC1D16_uc002jxk.1_Missense_Mutation_p.S172L	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	534	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			CACCAGGTCCGACATCCCTTG	0.602													44	10					0	0	0	0	A	77921571	A	A	77921571	3	1	285	1	0	0	0	0	1	0	0	0	15671	1059	37	1	718	1	TBC1D16	17	77921571	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	26019204	77921571	3273639	331	53186											
ZNF750	79755	broad.mit.edu	37	chr17	80789871	80789872	+	Frame_Shift_Ins	INS	-	T	T																															gaaggccgagctgcgccttcINScagagcaggctgggcaccga																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr17:80789871_80789872insT	uc002kga.2	-	2	770_771	c.459_460insA	c.(457-462)CTGGAAfs	p.L153fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	153_154						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTGCGCCTTCCAGAGCAGGCT	0.658													---	---	---								T	80789872	T	T	80789871	7	5	285	1	0	1	1	0	0	0	0	0	18199	864	30	0	1719	0	ZNF750	17	80789871	Frame_Shift_Ins	INS	-	TCGA-DQ-5629-01A-01D-1870-08	2868300	80789871	405339	332	53187											
IMPA2	3613	broad.mit.edu	37	chr18	11999122	11999122	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagctgcagatcttgtgacaGaaacagatcaccttgtggaa	13	9	10	9	0	2	4	1	1	1	3	2	5	2	5	1	1	3	2	1	1	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr18:11999122G>A	uc002kqp.1	+	2	380	c.166G>A	c.(166-168)GAA>AAA	p.E56K	IMPA2_uc002kqo.1_5'UTR|IMPA2_uc010dlb.1_5'UTR|IMPA2_uc002kqq.1_5'UTR	NM_014214	NP_055029	O14732	IMPA2_HUMAN	inositol(myo)-1(or 4)-monophosphatase 2	56					inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(2)	2					Lithium(DB01356)	TCTTGTGACAGAAACAGATCA	0.423													18	50					0	0	0	0	A	11999122	A	A	11999122	3	1	285	1	0	0	0	0	1	0	0	0	7762	943	33	2	172	2	IMPA2	18	11999122	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08		11999122	66078126	333	53188											
SLC39A6	25800	broad.mit.edu	37	chr18	33689681	33689681	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcggctacatccatggtcacTagcatcattgtgcagcattt	9	12	9	11	1	2	0	2	0	0	0	3	0	3	0	1	2	4	4	1	2	2	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr18:33689681T>A	uc010dmy.2	-	10	2433	c.2143A>T	c.(2143-2145)AGT>TGT	p.S715C		NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	715	Cytoplasmic (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						CCATGGTCACTAGCATCATTG	0.328													33	69					0	0	0	0	A	33689681	A	A	33689681	3	1	285	1	0	0	0	0	1	0	0	0	14686	1522	53	5	128	5	SLC39A6	18	33689681	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	21690559	33689681	44387567	334	53189											
DCC	1630	broad.mit.edu	37	chr18	50731677	50731677	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaccccctgcctatgcaaaCggtccagtccaaggttacag	11	7	9	14	1	0	0	0	0	0	0	2	1	2	0	5	2	5	2	5	2	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr18:50731677C>A	uc002lfe.1	+	10	2252	c.1665C>A	c.(1663-1665)AAC>AAA	p.N555K	DCC_uc010xdr.1_Missense_Mutation_p.N403K|DCC_uc010dpf.1_Missense_Mutation_p.N210K	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	555	Extracellular (Potential).|Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCTATGCAAACGGTCCAGTCC	0.478													48	102					9.57592e-29	1.32477e-28	1	0	A	50731677	A	A	50731677	3	1	285	1	0	0	0	0	1	0	0	0	4299	535	19	3	1703	3	DCC	18	50731677	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	17041996	50731677	27345571	335	53190											
HMHA1	23526	broad.mit.edu	37	chr19	1080350	1080350	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaagaaggcgggtgcacTgagggcacacctgccaagga	12	3	15	11	1	0	3	0	1	0	2	0	4	0	4	3	4	2	2	3	4	3	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:1080350T>A	uc002lqz.1	+	14	2031	c.1800T>A	c.(1798-1800)ACT>ACA	p.T600T	HMHA1_uc010xgd.1_Silent_p.T616T|HMHA1_uc010xge.1_Silent_p.T440T|HMHA1_uc002lra.1_Silent_p.T440T|HMHA1_uc002lrb.1_Silent_p.T483T|HMHA1_uc002lrc.1_Silent_p.T235T|HMHA1_uc002lrd.1_5'Flank|HMHA1_uc010dsd.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	600					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGGTGCACTGAGGGCACAC	0.706													6	29					0	0	0	0	A	1080350	A	A	1080350	2	1	285	1	0	0	0	0	0	0	0	1	7279	1567	55	5		5	HMHA1	19	1080350	Silent	SNP	T	TCGA-DQ-5629-01A-01D-1870-08		1080350	58048633	336	53191											
MUC16	94025	broad.mit.edu	37	chr19	9045667	9045667	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaggtggttgttgtcttGgccacagtgggactggaacc	7	12	15	7	0	1	1	0	1	1	0	1	3	1	3	2	5	1	2	2	5	2	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:9045667G>A	uc002mkp.2	-	5	36168	c.35964C>T	c.(35962-35964)GCC>GCT	p.A11988A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11990	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGTTGTCTTGGCCACAGTGG	0.493													11	47					0	0	0	0	A	9045667	A	A	9045667	2	1	285	1	0	0	0	0	0	0	0	1	10026	1335	47	4		4	MUC16	19	9045667	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	7965317	9045667	50083316	337	53192											
ZNF177	7730	broad.mit.edu	37	chr19	9492182	9492182	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acacacacgctctcacactgGagagaagccttatgagtgta	13	8	9	11	1	1	2	1	1	1	1	2	4	1	3	1	1	1	2	1	1	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:9492182G>C	uc002mli.2	+	12	1358	c.695G>C	c.(694-696)GGA>GCA	p.G232A	ZNF177_uc002mlj.2_Missense_Mutation_p.G182A|ZNF177_uc002mlk.2_Missense_Mutation_p.G232A	NM_003451	NP_003442	Q13360	ZN177_HUMAN	zinc finger protein 177	232					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTCACACTGGAGAGAAGCCT	0.468													34	92					0	0	0	0	C	9492182	C	C	9492182	3	2	285	1	0	0	0	0	1	0	0	0	17813	1174	41	2	1193	2	ZNF177	19	9492182	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	446515	9492182	49636801	338	53193											
RAD23A	5886	broad.mit.edu	37	chr19	13060139	13060139	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagccccagttccagaacAtgcggcaggtgattcagcag	11	6	11	13	1	1	2	1	1	0	1	2	2	2	2	4	2	4	3	4	2	1	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:13060139A>T	uc002mvw.1	+	7	839	c.730A>T	c.(730-732)ATG>TTG	p.M244L	RAD23A_uc002mvx.1_Missense_Mutation_p.M243L|RAD23A_uc002mvz.1_Missense_Mutation_p.M243L|RAD23A_uc002mwa.1_Missense_Mutation_p.M244L|RAD23A_uc002mvy.1_Missense_Mutation_p.M78L|RAD23A_uc010xmw.1_Missense_Mutation_p.M79L	NM_005053	NP_005044	P54725	RD23A_HUMAN	UV excision repair protein RAD23 homolog A	244					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)	1						GTTCCAGAACATGCGGCAGGT	0.637								NER					34	14					0	0	0	0	T	13060139	T	T	13060139	3	4	285	1	0	0	0	0	1	0	0	0	13047	217	8	5	756	5	RAD23A	19	13060139	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	3567957	13060139	46068844	339	53194											
EPS15L1	58513	broad.mit.edu	37	chr19	16528864	16528864	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaatgaaatacatagctaaCgcgaattggtctttgcttaa	14	13	8	6	2	1	2	0	2	1	0	1	3	1	2	0	1	4	2	0	1	7	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:16528864C>A	uc002ndz.1	-	11	1008	c.1002G>T	c.(1000-1002)GCG>GCT	p.A334A	EPS15L1_uc002ndx.2_Silent_p.A334A|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Silent_p.A224A|EPS15L1_uc010xpf.1_Silent_p.A237A|EPS15L1_uc002nea.1_Silent_p.A334A|EPS15L1_uc010eah.1_Silent_p.A334A|EPS15L1_uc002neb.1_Silent_p.A180A|EPS15L1_uc002nec.1_Silent_p.A334A	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	334	EH 3.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						ACATAGCTAACGCGAATTGGT	0.562											OREG0025334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	20					6.19805e-25	8.39436e-25	1	0	A	16528864	A	A	16528864	2	1	285	1	0	0	0	0	0	0	0	1	5217	523	19	3		3	EPS15L1	19	16528864	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	3468725	16528864	42600119	340	53195											
SIN3B	23309	broad.mit.edu	37	chr19	16962311	16962311	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagcaggaagcgctcccggcCctcgctcctccgccccgtgt	4	6	11	20	5	0	0	0	0	0	0	4	1	3	1	6	2	2	3	6	2	1	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:16962311C>T	uc002ney.1	+	6	829	c.815C>T	c.(814-816)CCC>CTC	p.P272L	SIN3B_uc002new.2_Missense_Mutation_p.P272L|SIN3B_uc002nex.2_Missense_Mutation_p.P204L|SIN3B_uc002nez.1_Missense_Mutation_p.P272L	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	272					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						CGCTCCCGGCCCTCGCTCCTC	0.652													11	49					0	0	0	0	T	16962311	T	T	16962311	3	4	285	1	0	0	0	0	1	0	0	0	14391	623	22	4	837	4	SIN3B	19	16962311	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	433447	16962311	42166672	341	53196											
CPAMD8	27151	broad.mit.edu	37	chr19	17039991	17039991	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cacatcaaagcgggtgaggcGcagtggccgctgcacatact	10	6	13	12	3	1	1	1	1	0	0	1	1	1	1	1	3	3	3	1	3	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:17039991G>T	uc002nfb.2	-	24	3078	c.3046C>A	c.(3046-3048)CGC>AGC	p.R1016S		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	969						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CGGGTGAGGCGCAGTGGCCGC	0.582													19	13					2.4624e-09	2.79733e-09	1	0	T	17039991	T	T	17039991	3	4	285	1	0	0	0	0	1	0	0	0	3810	1087	38	3	2828	3	CPAMD8	19	17039991	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	77680	17039991	42088992	342	53197											
FCHO1	23149	broad.mit.edu	37	chr19	17892276	17892276	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccagtctcgttccctgagcCcctccccactgggctcttca	4	11	7	19	1	3	1	1	1	2	0	7	1	6	1	6	1	1	2	6	1	0	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:17892276C>T	uc010ebb.2	+	21	1945	c.1756C>T	c.(1756-1758)CCC>TCC	p.P586S	FCHO1_uc002nhg.3_Missense_Mutation_p.P586S|FCHO1_uc002nhh.2_Missense_Mutation_p.P586S|FCHO1_uc010xpw.1_Missense_Mutation_p.P536S|FCHO1_uc002nhi.2_Missense_Mutation_p.P42S|FCHO1_uc002nhj.2_5'UTR	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	586										breast(1)	1						TTCCCTGAGCCCCTCCCCACT	0.637													18	12					0	0	0	0	T	17892276	T	T	17892276	3	4	285	1	0	0	0	0	1	0	0	0	5819	623	22	4	1830	4	FCHO1	19	17892276	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	852285	17892276	41236707	343	53198											
WDR62	284403	broad.mit.edu	37	chr19	36557244	36557244	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccacaagtatggtgtggCgtgtgtggccttctcaccca	7	10	13	11	1	1	0	1	0	1	0	2	0	1	0	3	4	0	1	3	4	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:36557244C>A	uc002odc.2	+	5	567	c.476C>A	c.(475-477)GCG>GAG	p.A159E	WDR62_uc002odd.2_Missense_Mutation_p.A159E|WDR62_uc002odb.2_Missense_Mutation_p.A159E	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	159	WD 2.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TATGGTGTGGCGTGTGTGGCC	0.562													7	6					1.26484e-09	1.44416e-09	1	0	A	36557244	A	A	36557244	3	1	285	1	0	0	0	0	1	0	0	0	17381	768	27	3	494	3	WDR62	19	36557244	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	18664968	36557244	22571739	344	53199											
ZFP82	284406	broad.mit.edu	37	chr19	36884242	36884242	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acattcatagggtttctcacCagtatgaagtttgtgatgta	11	15	9	6	0	2	2	2	2	1	0	3	2	2	2	1	1	0	4	1	1	4	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:36884242C>A	uc002ody.1	-	5	1235	c.1000G>T	c.(1000-1002)GGT>TGT	p.G334C		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						GGTTTCTCACCAGTATGAAGT	0.433													24	103					7.87624e-14	9.62652e-14	1	0	A	36884242	A	A	36884242	3	1	285	1	0	0	0	0	1	0	0	0	17720	594	21	4	602	4	ZFP82	19	36884242	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	326998	36884242	22244741	345	53200											
ZNF829	374899	broad.mit.edu	37	chr19	37382725	37382725	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacactgcttacattcataaGgtttctcaccagtatgcatt	11	14	5	11	0	2	0	2	0	1	0	3	0	2	0	1	1	3	4	1	1	3	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:37382725G>A	uc002ofa.1	-	6	1330	c.968C>T	c.(967-969)CCT>CTT	p.P323L	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	323					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACATTCATAAGGTTTCTCACC	0.403													17	68					0	0	0	0	A	37382725	A	A	37382725	3	1	285	1	0	0	0	0	1	0	0	0	18249	1000	35	4	334	4	ZNF829	19	37382725	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	498483	37382725	21746258	346	53201											
ZNF585B	92285	broad.mit.edu	37	chr19	37676276	37676276	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaggccttcccacactcAgcacacacgtaaggcttctc	11	8	6	16	1	2	0	1	0	1	0	4	0	3	0	2	2	1	3	2	2	3	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:37676276A>G	uc002ofq.2	-	5	2417	c.2163T>C	c.(2161-2163)GCT>GCC	p.A721A	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Silent_p.A535A	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	721	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCCCACACTCAGCACACACGT	0.463													37	115					0	0	0	0	G	37676276	G	G	37676276	2	3	285	1	0	0	0	0	0	0	0	1	18085	175	7	5		5	ZNF585B	19	37676276	Silent	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	293551	37676276	21452707	347	53202											
FAM98C	147965	broad.mit.edu	37	chr19	38893838	38893838	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgggagggggccgcggtggcCcaggacctgctggctctggg	3	6	21	11	2	1	0	0	0	1	0	1	2	1	2	3	8	1	2	3	8	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:38893838C>T	uc002oin.1	+	1	64	c.45C>T	c.(43-45)GCC>GCT	p.A15A	FAM98C_uc002oio.1_Silent_p.A15A|FAM98C_uc010xtz.1_Silent_p.A15A	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	15										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCGCGGTGGCCCAGGACCTGC	0.697													18	11					0	0	0	0	T	38893838	T	T	38893838	2	4	285	1	0	0	0	0	0	0	0	1	5690	610	22	4		4	FAM98C	19	38893838	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1217562	38893838	20235145	348	53203											
HNRNPL	3191	broad.mit.edu	37	chr19	39322049	39322049	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacacgaagggactcatagcTgtggtctggggcttcaccga	9	8	13	11	2	3	0	2	0	1	0	3	3	3	1	1	4	1	2	1	4	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:39322049T>A	uc002ojj.1	-	6	867	c.787A>T	c.(787-789)AGC>TGC	p.S263C	ECH1_uc002oji.2_Missense_Mutation_p.S54C|ECH1_uc010xuk.1_Missense_Mutation_p.S54C|HNRNPL_uc010ege.1_Intron	NM_001005335	NP_001005335	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	Error:Variant_position_missing_in_P14866_after_alignment					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			GACTCATAGCTGTGGTCTGGG	0.567													40	80					0	0	0	0	A	39322049	A	A	39322049	3	1	285	1	0	0	0	0	1	0	0	0	7309	1580	55	5		5	HNRNPL	19	39322049	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	428211	39322049	19806934	349	53204											
PRX	57716	broad.mit.edu	37	chr19	40901621	40901621	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcagggccctccacccgctCtcccttgcccattttagcgg	4	10	8	19	2	2	0	1	0	1	0	4	0	3	0	5	2	2	1	5	2	1	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:40901621C>T	uc002onr.2	-	7	2907	c.2638G>A	c.(2638-2640)GAG>AAG	p.E880K	PRX_uc002onq.2_Missense_Mutation_p.E741K|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	880					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCCACCCGCTCTCCCTTGCCC	0.632													9	26					0	0	0	0	T	40901621	T	T	40901621	3	4	285	1	0	0	0	0	1	0	0	0	12704	922	32	2	1751	2	PRX	19	40901621	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1579572	40901621	18227362	350	53205											
PSG9	5678	broad.mit.edu	37	chr19	43772264	43772264	+	Frame_Shift_Del	DEL	G	-	-																															tgggcttcaatcgtgacttcGgcagtggtgggcgggttcca																								rs143419745	byFrequency	TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:43772264delG	uc002owd.3	-	2	201	c.102delC	c.(100-102)GCCfs	p.A34fs	PSG9_uc002owe.3_Frame_Shift_Del_p.A34fs|PSG9_uc010xwm.1_Frame_Shift_Del_p.A34fs|PSG9_uc002owf.3_Frame_Shift_Del_p.A34fs|PSG9_uc002owg.2_Frame_Shift_Del_p.A34fs|PSG9_uc002owh.2_Frame_Shift_Del_p.A34fs	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	34					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TCGTGACTTCGGCAGTGGTGG	0.488													---	---	---								-	43772264	-	-	43772264	7	5	285	1	0	1	0	1	0	0	0	0	12724	1103	39	0	1198	0	PSG9	19	43772264	Frame_Shift_Del	DEL	G	TCGA-DQ-5629-01A-01D-1870-08	2870643	43772264	15356719	351	53206											
IRGQ	126298	broad.mit.edu	37	chr19	44096234	44096234	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcatcagcccgcatctcatCgagagcctgcagcaggacgc	10	5	11	15	3	2	1	2	0	1	1	4	3	2	2	2	1	5	4	2	1	0	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:44096234C>T	uc002oww.2	-	2	1934	c.1816G>A	c.(1816-1818)GAT>AAT	p.D606N	IRGQ_uc010eiv.2_Missense_Mutation_p.D606N	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	606	Ala-rich.						protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				CGCATCTCATCGAGAGCCTGC	0.682													16	93					0	0	0	0	T	44096234	T	T	44096234	3	4	285	1	0	0	0	0	1	0	0	0	7878	884	31	1	59	1	IRGQ	19	44096234	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	323970	44096234	15032749	352	53207											
GYS1	2997	broad.mit.edu	37	chr19	49484827	49484827	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggcctttgagggtttccaCgttgaaattgttggtccgcg	5	15	13	8	3	0	2	0	2	0	0	2	2	2	2	3	3	0	3	3	3	1	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:49484827C>A	uc002plp.2	-	8	1370	c.1129G>T	c.(1129-1131)GTG>TTG	p.V377L	GYS1_uc010xzy.1_Missense_Mutation_p.V10L|GYS1_uc010emm.2_Missense_Mutation_p.V313L|GYS1_uc010xzz.1_Missense_Mutation_p.V297L|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	377					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		AGGGTTTCCACGTTGAAATTG	0.597													26	18					2.49534e-26	3.4103e-26	1	0	A	49484827	A	A	49484827	3	1	285	1	0	0	0	0	1	0	0	0	6951	536	19	3	1120	3	GYS1	19	49484827	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	5388593	49484827	9644156	353	53208											
LILRA2	11027	broad.mit.edu	37	chr19	55087488	55087488	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcctgtgacctcagcccaCgtggggacctacagatgcta	8	8	12	13	1	1	2	1	1	0	1	2	3	2	3	4	3	3	1	4	3	2	2	rs140195058		TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:55087488C>A	uc002qgg.3	+	6	1256	c.1167C>A	c.(1165-1167)CAC>CAA	p.H389Q	LILRA2_uc010ern.2_Missense_Mutation_p.H389Q|LILRA2_uc002qgf.2_Missense_Mutation_p.H389Q|LILRA2_uc010yfe.1_Missense_Mutation_p.H389Q|LILRA2_uc010yff.1_Missense_Mutation_p.H377Q|LILRA2_uc010ero.2_Missense_Mutation_p.H377Q|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	389	Ig-like C2-type 4.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CCTCAGCCCACGTGGGGACCT	0.622													43	78					9.14704e-12	1.09135e-11	1	0	A	55087488	A	A	55087488	3	1	285	1	0	0	0	0	1	0	0	0	8826	535	19	3	1189	3	LILRA2	19	55087488	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	5602661	55087488	4041495	354	53209											
NLRP8	126205	broad.mit.edu	37	chr19	56473475	56473475	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	catcgttggtggcaagacttAtgctctgtgtttgcaacgaa	9	13	11	8	2	1	1	0	0	1	1	2	2	1	1	0	2	3	5	0	2	4	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:56473475A>C	uc002qmh.2	+	4	2156	c.2085A>C	c.(2083-2085)TTA>TTC	p.L695F	NLRP8_uc010etg.2_Missense_Mutation_p.L695F	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	695						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GGCAAGACTTATGCTCTGTGT	0.493													44	85					0	0	0	0	C	56473475	C	C	56473475	3	2	285	1	0	0	0	0	1	0	0	0	10537	446	16	5	2099	5	NLRP8	19	56473475	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	1385987	56473475	2655508	355	53210											
AURKC	6795	broad.mit.edu	37	chr19	57744010	57744010	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgagctctacaaggagctgCagaaaagcgagaaattagat	16	7	12	6	1	1	4	0	1	1	3	1	6	1	5	0	1	5	3	0	1	6	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr19:57744010C>G	uc002qoe.2	+	4	586	c.397C>G	c.(397-399)CAG>GAG	p.Q133E	AURKC_uc002qoc.2_Missense_Mutation_p.Q114E|AURKC_uc002qod.2_Missense_Mutation_p.Q99E|AURKC_uc010etv.2_Missense_Mutation_p.Q130E	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	133	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		CAAGGAGCTGCAGAAAAGCGA	0.542													15	67					0	0	0	0	G	57744010	G	G	57744010	3	3	285	1	0	0	0	0	1	0	0	0	1226	711	25	4	416	4	AURKC	19	57744010	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	1270535	57744010	1384973	356	53211											
PAK7	57144	broad.mit.edu	37	chr20	9525142	9525142	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaatcagacaactttatCtgaaaaggaaaggaatgcaa	20	7	7	7	0	2	2	1	1	1	1	2	4	2	4	1	2	2	1	1	2	9	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:9525142C>A	uc002wnl.2	-	9	2289	c.1744_splice	c.e9-1	p.I582_splice	PAK7_uc002wnk.2_Splice_Site_p.I582_splice|PAK7_uc002wnj.2_Splice_Site_p.I582_splice|PAK7_uc010gby.1_Intron	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7								ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ACAACTTTATCTGAAAAGGAA	0.388													12	45					4.3838e-07	4.81045e-07	1	0	A	9525142	A	A	9525142	5	1	285	1	0	0	0	0	0	0	1	0	11459	927	32	2	428	2	PAK7	20	9525142	Splice_Site	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		9525142	53500378	357	53212											
SEL1L2	80343	broad.mit.edu	37	chr20	13847353	13847353	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatattatatttacctccaCagcagttctgcatgatctta	11	15	5	10	0	2	1	0	1	2	0	3	1	3	1	2	0	3	4	2	0	5	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:13847353C>A	uc010gcf.2	-	15	1481	c.1399G>T	c.(1399-1401)GTG>TTG	p.V467L	SEL1L2_uc002woq.3_Missense_Mutation_p.V328L|SEL1L2_uc010zrl.1_Missense_Mutation_p.V467L|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	467	Extracellular (Potential).|Sel1-like 9.					integral to membrane	binding			ovary(2)	2						TTTACCTCCACAGCAGTTCTG	0.398													32	51					6.00712e-18	7.71855e-18	1	0	A	13847353	A	A	13847353	3	1	285	1	0	0	0	0	1	0	0	0	14076	478	17	4	691	4	SEL1L2	20	13847353	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	4322211	13847353	49178167	358	53213											
SEL1L2	80343	broad.mit.edu	37	chr20	13847424	13847424	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ccagataataaatggcaaggGgctgcccactctgagatgcc	12	7	11	11	0	1	2	0	1	1	2	1	3	1	2	3	3	2	2	3	3	4	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:13847424G>A	uc010gcf.2	-	15	1410	c.1328C>T	c.(1327-1329)CCC>CTC	p.P443L	SEL1L2_uc002woq.3_Missense_Mutation_p.P304L|SEL1L2_uc010zrl.1_Missense_Mutation_p.P443L|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	443	Extracellular (Potential).|Sel1-like 9.					integral to membrane	binding			ovary(2)	2						AATGGCAAGGGGCTGCCCACT	0.408													32	41					0	0	0	0	A	13847424	A	A	13847424	3	1	285	1	0	0	0	0	1	0	0	0	14076	1232	43	4	762	4	SEL1L2	20	13847424	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	71	13847424	49178096	359	53214											
NINL	22981	broad.mit.edu	37	chr20	25456905	25456905	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactgtgcttgtgacaccCaggctccagggcgccctcgg	6	7	12	16	2	0	1	0	1	0	0	2	1	1	1	3	3	1	2	3	3	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:25456905C>A	uc002wux.1	-	17	3096	c.3022G>T	c.(3022-3024)GGG>TGG	p.G1008W	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1008					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TTGTGACACCCAGGCTCCAGG	0.677													35	25					1.60099e-16	2.00568e-16	1	0	A	25456905	A	A	25456905	3	1	285	1	0	0	0	0	1	0	0	0	10474	594	21	4	1158	4	NINL	20	25456905	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	11609481	25456905	37568615	360	53215											
DEFB118	117285	broad.mit.edu	37	chr20	29960690	29960690	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaaaaaaaatgctggaacaGatcagggcactgcaggaaac	18	5	11	7	0	1	2	1	1	0	1	1	4	1	4	0	3	4	3	0	3	6	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:29960690G>C	uc002wvr.2	+	2	115	c.89G>C	c.(88-90)AGA>ACA	p.R30T		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	30					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TGCTGGAACAGATCAGGGCAC	0.403													6	30					0	0	0	0	C	29960690	C	C	29960690	3	2	285	1	0	0	0	0	1	0	0	0	4427	942	33	2	95	2	DEFB118	20	29960690	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4503785	29960690	33064830	361	53216											
C20orf117	140710	broad.mit.edu	37	chr20	35422872	35422872	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtctttctctggatcccCtggctcggagctcacaaagc	6	11	11	13	1	3	0	1	0	2	0	6	2	4	2	2	4	2	2	2	4	1	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:35422872C>A	uc002xgd.1	-	14	3226	c.2899G>T	c.(2899-2901)GGG>TGG	p.G967W	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	967											0		Myeloproliferative disorder(115;0.00874)				TCTGGATCCCCTGGCTCGGAG	0.612													28	32					1.77063e-15	2.18782e-15	1	0	A	35422872	A	A	35422872	3	1	285	1	0	0	0	0	1	0	0	0	2093	681	24	4	1442	4	C20orf117	20	35422872	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	5462182	35422872	27602648	362	53217											
KIAA1755	85449	broad.mit.edu	37	chr20	36869128	36869128	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gaatgagaatttgagcccagGagtggggggctcaggggagg	10	6	20	5	0	1	2	1	2	0	1	1	6	1	4	1	7	1	1	1	7	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:36869128G>T	uc002xhy.1	-	3	1677	c.1405C>A	c.(1405-1407)CCT>ACT	p.P469T	KIAA1755_uc002xhz.1_Missense_Mutation_p.P469T	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	469										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				TTGAGCCCAGGAGTGGGGGGC	0.552													17	43					4.75885e-15	5.86405e-15	1	0	T	36869128	T	T	36869128	3	4	285	1	0	0	0	0	1	0	0	0	8296	1174	41	2	2245	2	KIAA1755	20	36869128	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	1446256	36869128	26156392	363	53218											
SPATA2	9825	broad.mit.edu	37	chr20	48522917	48522917	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagactcaatgaggccttcaGgggtggcttccggctctccc	7	9	12	13	1	3	2	2	1	1	1	5	2	4	2	3	5	0	2	3	5	2	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:48522917G>T	uc010gie.2	-	3	1152	c.802C>A	c.(802-804)CTG>ATG	p.L268M	SPATA2_uc002xuw.2_Missense_Mutation_p.L268M|SPATA2_uc010zyn.1_Missense_Mutation_p.L131M	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	268					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			GAGGCCTTCAGGGGTGGCTTC	0.617													30	38					2.85442e-18	3.68866e-18	1	0	T	48522917	T	T	48522917	3	4	285	1	0	0	0	0	1	0	0	0	15071	991	35	4	764	4	SPATA2	20	48522917	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	11653789	48522917	14502603	364	53219											
FAM65C	140876	broad.mit.edu	37	chr20	49225879	49225879	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgaacctccagggccccctcGatgagccacatgtcctgcaa	9	7	9	16	1	0	2	0	2	0	0	3	3	2	2	6	1	3	1	6	1	2	0			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:49225879G>C	uc002xvm.2	-	8	897	c.579C>G	c.(577-579)ATC>ATG	p.I193M	FAM65C_uc010zyt.1_Missense_Mutation_p.I197M|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.I193M	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	193										ovary(2)	2						GGGCCCCCTCGATGAGCCACA	0.647													6	11					0	0	0	0	C	49225879	C	C	49225879	3	2	285	1	0	0	0	0	1	0	0	0	5633	1048	37	3	2321	3	FAM65C	20	49225879	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	702962	49225879	13799641	365	53220											
DOK5	55816	broad.mit.edu	37	chr20	53227044	53227044	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcacgagcgcttgctacaGagtgtgaaaaactcgatggt	12	8	12	9	3	0	2	0	1	0	1	1	4	0	2	0	1	5	3	0	1	3	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:53227044G>C	uc002xwy.2	+	6	937	c.717G>C	c.(715-717)CAG>CAC	p.Q239H	DOK5_uc010gin.2_Missense_Mutation_p.Q131H|DOK5_uc002xwz.2_Missense_Mutation_p.Q101H	NM_018431	NP_060901	Q9P104	DOK5_HUMAN	docking protein 5	239							insulin receptor binding			ovary(1)	1			Colorectal(105;0.202)			GCTTGCTACAGAGTGTGAAAA	0.498													11	31					0	0	0	0	C	53227044	C	C	53227044	3	2	285	1	0	0	0	0	1	0	0	0	4722	933	33	2	739	2	DOK5	20	53227044	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	4001165	53227044	9798476	366	53221											
TAF4	6874	broad.mit.edu	37	chr20	60584179	60584179	+	Nonsense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttgccagatgaagccagttTtattaacgtagataggaaat	14	12	9	6	1	0	3	0	1	0	2	0	4	0	4	2	1	3	2	2	1	6	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:60584179T>A	uc002ybs.2	-	5	1813	c.1813A>T	c.(1813-1815)AAA>TAA	p.K605*		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	605	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			GAAGCCAGTTTTATTAACGTA	0.348													38	51					0	0	0	0	A	60584179	A	A	60584179	4	1	285	1	0	0	0	0	0	1	0	0	15592	1850	64	5	1488	5	TAF4	20	60584179	Nonsense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	7357135	60584179	2441341	367	53222											
OPRL1	4987	broad.mit.edu	37	chr20	62729191	62729191	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagccaccaatatttacatCtttaacctggccctggccga	11	10	6	14	1	1	0	0	0	1	0	1	1	1	0	5	2	3	0	5	2	4	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:62729191C>G	uc002yic.2	+	4	672	c.270C>G	c.(268-270)ATC>ATG	p.I90M	OPRL1_uc002yid.2_Missense_Mutation_p.I90M|OPRL1_uc002yif.3_Missense_Mutation_p.I85M	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	90	Helical; Name=2; (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					ATATTTACATCTTTAACCTGG	0.577													42	116					0	0	0	0	G	62729191	G	G	62729191	3	3	285	1	0	0	0	0	1	0	0	0	10940	903	32	2	276	2	OPRL1	20	62729191	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	2145012	62729191	296329	368	53223											
MYT1	4661	broad.mit.edu	37	chr20	62837126	62837126	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagacgtcaggacaggacGagattcatcgccccgagaca	12	5	12	12	4	2	3	2	1	0	3	3	8	2	5	2	2	0	0	2	2	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr20:62837126G>T	uc002yii.2	+	6	734	c.370G>T	c.(370-372)GAG>TAG	p.E124*	MYT1_uc002yih.2_Nonsense_Mutation_p.E124*|MYT1_uc002yij.2_5'Flank	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	124					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGGACAGGACGAGATTCATCG	0.587													7	24					8.12818e-05	8.56498e-05	1	0	T	62837126	T	T	62837126	4	4	285	1	0	0	0	0	0	1	0	0	10159	1059	37	3	384	3	MYT1	20	62837126	Nonsense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	107935	62837126	188394	369	53224											
MICAL3	57553	broad.mit.edu	37	chr22	18273802	18273802	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggagctcctgctgcagtCgactctgccggtcttccagc	4	9	11	17	3	2	0	0	0	2	0	5	2	4	1	4	2	5	3	4	2	0	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr22:18273802C>A	uc002zng.3	-	31	6139	c.5786G>T	c.(5785-5787)CGA>CTA	p.R1929L	MICAL3_uc011agl.1_Missense_Mutation_p.R1845L|MICAL3_uc010grd.1_Missense_Mutation_p.R45L|MICAL3_uc010gre.1_RNA	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1929	Potential.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CTGCTGCAGTCGACTCTGCCG	0.662													9	14					1.12685e-05	1.21002e-05	1	0	A	18273802	A	A	18273802	3	1	285	1	0	0	0	0	1	0	0	0	9624	884	31	3	230	3	MICAL3	22	18273802	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		18273802	33030764	370	53225											
RIMBP3	85376	broad.mit.edu	37	chr22	20458180	20458180	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcacaggccctggaaggtgTagcagctcacgcccgctggg	7	5	16	13	2	1	0	1	0	0	0	1	1	1	1	2	5	2	5	2	5	2	1			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr22:20458180T>A	uc002zsd.3	-	1	3607	c.3122A>T	c.(3121-3123)TAC>TTC	p.Y1041F		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			CTGGAAGGTGTAGCAGCTCAC	0.642													4	29					0	0	0	0	A	20458180	A	A	20458180	3	1	285	1	0	0	0	0	1	0	0	0	13429	1638	57	5	1801	5	RIMBP3	22	20458180	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	2184378	20458180	30846386	371	53226											
ZNF280B	140883	broad.mit.edu	37	chr22	22843194	22843194	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttatgctgtttacttcgaaaGtggaaagttgctttgataca	11	16	9	5	1	0	1	0	1	0	0	1	3	0	2	0	1	4	4	0	1	5	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr22:22843194G>C	uc002zwc.1	-	4	1306	c.530C>G	c.(529-531)ACT>AGT	p.T177S	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TACTTCGAAAGTGGAAAGTTG	0.383													68	66					0	0	0	0	C	22843194	C	C	22843194	3	2	285	1	0	0	0	0	1	0	0	0	17882	1029	36	4	1105	4	ZNF280B	22	22843194	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	2385014	22843194	28461372	372	53227											
ADRBK2	157	broad.mit.edu	37	chr22	26040617	26040617	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgaagctgtacctcaggtGaagttttatgaagaggtaag	14	11	12	4	0	1	4	1	3	0	1	1	4	1	4	1	2	2	4	1	2	7	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr22:26040617G>A	uc003abx.3	+	3	396	c.249G>A	c.(247-249)GTG>GTA	p.V83V	ADRBK2_uc010gux.2_Silent_p.V83V|ADRBK2_uc003abw.2_5'UTR|ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	83	N-terminal.|RGS.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	TACCTCAGGTGAAGTTTTATG	0.279													8	15					0	0	0	0	A	26040617	A	A	26040617	2	1	285	1	0	0	0	0	0	0	0	1	344	1277	45	2		2	ADRBK2	22	26040617	Silent	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	3197423	26040617	25263949	373	53228											
HPS4	89781	broad.mit.edu	37	chr22	26860632	26860632	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagcatccgttctccttccTgccatctggacaagcttcgt	7	12	7	15	2	2	0	0	0	2	0	6	1	4	1	4	1	3	3	4	1	2	3			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chr22:26860632T>C	uc003acl.2	-	11	1623	c.964A>G	c.(964-966)AGG>GGG	p.R322G	HPS4_uc003aci.2_Missense_Mutation_p.R317G|HPS4_uc003acj.2_Missense_Mutation_p.R186G|HPS4_uc003ack.2_Missense_Mutation_p.R113G|HPS4_uc003acn.2_Missense_Mutation_p.R168G|HPS4_uc010gvd.1_Missense_Mutation_p.R340G|HPS4_uc003ach.2_Missense_Mutation_p.R57G	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	322					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						TTCTCCTTCCTGCCATCTGGA	0.587									Hermansky-Pudlak_syndrome				16	67					0	0	0	0	C	26860632	C	C	26860632	3	2	285	1	0	0	0	0	1	0	0	0	7380	1579	55	5	1178	5	HPS4	22	26860632	Missense_Mutation	SNP	T	TCGA-DQ-5629-01A-01D-1870-08	820015	26860632	24443934	374	53229											
CXorf22	170063	broad.mit.edu	37	chrX	35969932	35969932	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattacagggtacagatattCaacaaagaacagatattgct	17	11	7	6	0	1	3	1	0	0	3	1	3	1	3	0	1	5	2	0	1	8	7			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chrX:35969932C>T	uc004ddj.2	+	6	957	c.898C>T	c.(898-900)CAA>TAA	p.Q300*	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	300										large_intestine(1)|lung(1)|ovary(1)	3						TACAGATATTCAACAAAGAAC	0.279													5	8					0	0	0	0	T	35969932	T	T	35969932	4	4	285	1	0	0	0	0	0	1	0	0	4119	827	29	2	920	2	CXorf22	23	35969932	Nonsense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08		35969932	119300628	375	53230											
ITIH5L	347365	broad.mit.edu	37	chrX	54784495	54784495	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tagaggcagtagtagttgagGataagtagaactttggtttc	12	13	13	3	0	0	3	0	1	0	2	1	4	0	4	0	3	1	6	0	3	6	8			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chrX:54784495G>C	uc004dtj.2	-	8	2042	c.2012C>G	c.(2011-2013)TCC>TGC	p.S671C		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	671					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						AGTAGTTGAGGATAAGTAGAA	0.522													17	64					0	0	0	0	C	54784495	C	C	54784495	3	2	285	1	0	0	0	0	1	0	0	0	7947	1174	41	2	1953	2	ITIH5L	23	54784495	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	18814563	54784495	100486065	376	53231											
ITIH5L	347365	broad.mit.edu	37	chrX	54784525	54784525	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actttggtttcacaggccttGatttgggggagatgaccttg	7	14	13	7	0	1	3	1	2	0	1	1	4	1	3	2	4	0	1	2	4	0	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chrX:54784525G>C	uc004dtj.2	-	8	2012	c.1982C>G	c.(1981-1983)TCA>TGA	p.S661*		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	661					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CACAGGCCTTGATTTGGGGGA	0.542													12	47					0	0	0	0	C	54784525	C	C	54784525	4	2	285	1	0	0	0	0	0	1	0	0	7947	1294	45	2	1983	2	ITIH5L	23	54784525	Nonsense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	30	54784525	100486035	377	53232											
ATRX	546	broad.mit.edu	37	chrX	76938209	76938209	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcatcttcagaagagtcaaAatcttttgtatttggaattc	12	16	6	7	0	5	2	3	0	2	2	6	3	5	3	0	1	0	1	0	1	5	6			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chrX:76938209A>T	uc004ecp.3	-	9	2771	c.2539T>A	c.(2539-2541)TTT>ATT	p.F847I	ATRX_uc004ecq.3_Missense_Mutation_p.F809I|ATRX_uc004eco.3_Missense_Mutation_p.F632I|ATRX_uc004ecr.2_Missense_Mutation_p.F779I|ATRX_uc010nlx.1_Missense_Mutation_p.F818I|ATRX_uc010nly.1_Missense_Mutation_p.F792I	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	847					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GAAGAGTCAAAATCTTTTGTA	0.249			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						101	175					0	0	0	0	T	76938209	T	T	76938209	3	4	285	1	0	0	0	0	1	0	0	0	1210	14	1	5	5047	5	ATRX	23	76938209	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	22153684	76938209	78332351	378	53233											
DACH2	117154	broad.mit.edu	37	chrX	85969660	85969661	+	Frame_Shift_Ins	INS	-	A	A																															accatctcaatactattgccINSaacatggctgctgcagcaca																										TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chrX:85969660_85969661insA	uc004eew.2	+	6	1211_1212	c.1041_1042insA	c.(1039-1044)GCCAACfs	p.A347fs	DACH2_uc004eex.2_Frame_Shift_Ins_p.A334fs|DACH2_uc010nmq.2_Frame_Shift_Ins_p.A213fs|DACH2_uc011mra.1_Frame_Shift_Ins_p.A180fs|DACH2_uc010nmr.2_Frame_Shift_Ins_p.A128fs|DACH2_uc004eey.2_Frame_Shift_Ins_p.A30fs|DACH2_uc004eez.2_Frame_Shift_Ins_p.A30fs	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	347_348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						ATACTATTGCCAACATGGCTGC	0.446													---	---	---								A	85969661	A	A	85969660	7	5	285	1	0	1	1	0	0	0	0	0	4238	581	21	0	1063	0	DACH2	23	85969660	Frame_Shift_Ins	INS	-	TCGA-DQ-5629-01A-01D-1870-08	9031451	85969660	69300900	379	53234											
PCDH11X	27328	broad.mit.edu	37	chrX	91131853	91131853	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccacaactgattgttcaaaAggagttagatagggaagaga	16	8	12	5	0	1	3	1	1	0	2	1	6	1	5	1	2	1	2	1	2	6	4			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chrX:91131853A>T	uc004efk.1	+	2	1459	c.614A>T	c.(613-615)AAG>ATG	p.K205M	PCDH11X_uc004efl.1_Missense_Mutation_p.K205M|PCDH11X_uc004efo.1_Missense_Mutation_p.K205M|PCDH11X_uc010nmv.1_Missense_Mutation_p.K205M|PCDH11X_uc004efm.1_Missense_Mutation_p.K205M|PCDH11X_uc004efn.1_Missense_Mutation_p.K205M|PCDH11X_uc004efh.1_Missense_Mutation_p.K205M|PCDH11X_uc004efj.1_Missense_Mutation_p.K205M	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	205	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ATTGTTCAAAAGGAGTTAGAT	0.398													21	53					0	0	0	0	T	91131853	T	T	91131853	3	4	285	1	0	0	0	0	1	0	0	0	11562	72	3	5	620	5	PCDH11X	23	91131853	Missense_Mutation	SNP	A	TCGA-DQ-5629-01A-01D-1870-08	5162193	91131853	64138707	380	53235											
VSIG1	340547	broad.mit.edu	37	chrX	107310364	107310364	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctcaacgtcagtgtgttaGgtatgagcacttttttctgc	7	16	9	9	1	3	1	2	1	1	0	4	1	4	1	1	1	3	3	1	1	3	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chrX:107310364G>A	uc004eno.2	+	3	573	c.412G>A	c.(412-414)GTG>ATG	p.V138M	VSIG1_uc011msk.1_Missense_Mutation_p.V174M	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	138	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CAGTGTGTTAGGTATGAGCAC	0.438													73	16					0	0	0	0	A	107310364	A	A	107310364	3	1	285	1	0	0	0	0	1	0	0	0	17290	1014	35	4	534	4	VSIG1	23	107310364	Missense_Mutation	SNP	G	TCGA-DQ-5629-01A-01D-1870-08	16178511	107310364	47960196	381	53236											
CAPN6	827	broad.mit.edu	37	chrX	110495672	110495672	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agccaatgtgcccgtgaagtCcacaataatatcagtgatgg	13	9	10	9	1	1	2	1	2	0	0	2	2	2	2	3	1	2	0	3	1	5	2			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chrX:110495672C>A	uc004epc.1	-	5	730	c.562G>T	c.(562-564)GAC>TAC	p.D188Y	CAPN6_uc011msu.1_Intron	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	188	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						CCCGTGAAGTCCACAATAATA	0.433													35	14					6.70999e-13	8.06988e-13	1	0	A	110495672	A	A	110495672	3	1	285	1	0	0	0	0	1	0	0	0	2642	855	30	2	1399	2	CAPN6	23	110495672	Missense_Mutation	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	3185308	110495672	44774888	382	53237											
SPRY3	10251	broad.mit.edu	37	chrX	155003585	155003585	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaattctgcctattgaacagCtgcgctctactcatgctagc	10	12	7	12	1	3	1	1	1	2	0	3	1	3	1	1	0	7	3	1	0	5	5			TCGA-DQ-5629-01A-01D-1870-08	TCGA-DQ-5629-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e748f828-0b80-47f3-aa92-fb3b2be0dcc2	1b1a16fa-937e-4a09-a53e-20a9057b47d8	g.chrX:155003585C>T	uc004fnq.1	+	2	506	c.52C>T	c.(52-54)CTG>TTG	p.L18L	SPRY3_uc010nvl.1_Silent_p.L18L	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	18					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TATTGAACAGCTGCGCTCTAC	0.488													74	39					0	0	0	0	T	155003585	T	T	155003585	2	4	285	1	0	0	0	0	0	0	0	1	15173	796	28	4		4	SPRY3	23	155003585	Silent	SNP	C	TCGA-DQ-5629-01A-01D-1870-08	44507913	155003585	266975	383	53238											
NPHP4	261734	broad.mit.edu	37	chr1	5947504	5947504	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtgggaggcctgcacagccGgccggccttggcggaggaga	6	4	19	12	4	0	1	0	0	0	1	0	4	0	3	4	7	2	1	4	7	0	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:5947504G>A	uc001alq.1	-	18	2593	c.2327C>T	c.(2326-2328)CCG>CTG	p.P776L	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_RNA|NPHP4_uc001alt.1_RNA|NPHP4_uc009vlu.1_RNA	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	776			P -> R (in NPHP4).		actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCACAGCCGGCCGGCCTTG	0.637													10	46					0	0	0	0	A	5947504	A	A	5947504	3	1	286	1	0	0	0	0	1	0	0	0	10635	1116	39	1	2005	1	NPHP4	1	5947504	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08		5947504	243303117	1	53239											
VPS13D	55187	broad.mit.edu	37	chr1	12446279	12446279	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggtggaattgggttgtcCttaattaataaagtcccaga	13	12	11	5	0	0	1	0	0	0	1	2	3	2	2	2	3	0	1	2	3	6	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:12446279C>T	uc001atv.2	+	60	11661	c.11520C>T	c.(11518-11520)TCC>TCT	p.S3840S	VPS13D_uc001atw.2_Silent_p.S3815S|VPS13D_uc001atx.2_Silent_p.S3027S|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3839					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTGGGTTGTCCTTAATTAATA	0.428													8	143					0	0	0	0	T	12446279	T	T	12446279	2	4	286	1	0	0	0	0	0	0	0	1	17260	668	24	4		4	VPS13D	1	12446279	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	6498775	12446279	236804342	2	53240											
ARID1A	8289	broad.mit.edu	37	chr1	27088796	27088796	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatggtccccaggggggtcAgtatggcccacaaggtcagt	8	8	14	11	0	2	0	2	0	0	0	3	0	3	0	3	6	0	1	3	6	3	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:27088796A>C	uc001bmv.1	+	7	2778	c.2405A>C	c.(2404-2406)CAG>CCG	p.Q802P	ARID1A_uc001bmt.1_Missense_Mutation_p.Q802P|ARID1A_uc001bmu.1_Missense_Mutation_p.Q802P|ARID1A_uc001bmw.1_Missense_Mutation_p.Q419P	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	802					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAGGGGGGTCAGTATGGCCCA	0.532			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								14	80					0	0	0	0	C	27088796	C	C	27088796	3	2	286	1	0	0	0	0	1	0	0	0	913	188	7	5	2431	5	ARID1A	1	27088796	Missense_Mutation	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	14642517	27088796	222161825	3	53241											
C1orf175	374977	broad.mit.edu	37	chr1	55118866	55118866	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgatgacagcagagctatCgctccagcctccctccagat	9	8	8	16	1	0	4	0	2	0	2	4	4	3	4	5	0	3	3	5	0	1	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:55118866C>A	uc010ooe.1	+	3	591	c.267C>A	c.(265-267)ATC>ATA	p.I89I	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxo.2_Silent_p.I89I|C1orf175_uc010ooc.1_Intron|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Intron|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Silent_p.I89I|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	89						integral to membrane	binding				0						GCAGAGCTATCGCTCCAGCCT	0.557													4	93					0.00909568	0.00952071	1	0	A	55118866	A	A	55118866	2	1	286	1	0	0	0	0	0	0	0	1	2025	874	31	3		3	C1orf175	1	55118866	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	28030070	55118866	194131755	4	53242											
HFM1	164045	broad.mit.edu	37	chr1	91851392	91851392	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcagatattttaaataatCtgcaaacaaaaaaaagaccc	20	10	4	7	0	2	2	1	0	1	2	2	2	2	2	1	0	2	1	1	0	9	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:91851392C>G	uc001doa.3	-	5	595	c.495_splice	c.e5-1	p.R165_splice	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Splice_Site_p.R165_splice	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein								ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TTTAAATAATCTGCAAACAAA	0.328													5	59					0	0	0	0	G	91851392	G	G	91851392	5	3	286	1	0	0	0	0	0	0	1	0	7122	927	32	2	3953	2	HFM1	1	91851392	Splice_Site	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	36732526	91851392	157399229	5	53243											
CELSR2	1952	broad.mit.edu	37	chr1	109793507	109793507	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaccacggcatgccccgacGaagtgccctggctacactca	9	5	11	16	3	1	0	1	0	0	0	1	3	1	1	4	3	3	2	4	3	2	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:109793507G>T	uc001dxa.3	+	1	867	c.806G>T	c.(805-807)CGA>CTA	p.R269L		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	269	Cadherin 1.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		ATGCCCCGACGAAGTGCCCTG	0.592													8	59					1.06961e-07	1.19797e-07	1	0	T	109793507	T	T	109793507	3	4	286	1	0	0	0	0	1	0	0	0	3237	1058	37	3	808	3	CELSR2	1	109793507	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	17942115	109793507	139457114	6	53244											
CELSR2	1952	broad.mit.edu	37	chr1	109794913	109794915	+	In_Frame_Del	DEL	GAT	-	-																															tggtgctgatcagcgccacgGatgaggacacaggtgagaat																										TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:109794913_109794915delGAT	uc001dxa.3	+	1	2273_2275	c.2212_2214delGAT	c.(2212-2214)GATdel	p.D738del		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	738	Cadherin 6.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CAGCGCCACGGATGAGGACACAG	0.596													---	---	---								-	109794915	-	-	109794913	7	5	286	1	0	1	0	1	0	0	0	0	3237	1174	41	0	2214	0	CELSR2	1	109794913	In_Frame_Del	DEL	GAT	TCGA-DQ-5630-01A-01D-1870-08	1406	109794913	139455708	7	53245											
SORT1	6272	broad.mit.edu	37	chr1	109897024	109897024	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaaagataatcagaattctGagggctatacatcatctgag	16	11	8	6	0	4	4	2	2	2	2	4	4	4	4	0	1	1	1	0	1	6	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:109897024G>C	uc001dxm.1	-	5	722	c.673C>G	c.(673-675)CAG>GAG	p.Q225E	SORT1_uc010ovi.1_Missense_Mutation_p.Q89E|SORT1_uc009wfb.2_Missense_Mutation_p.Q89E	NM_002959	NP_002950	Q99523	SORT_HUMAN	sortilin 1 preproprotein	225	Extracellular (Potential).				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		TCAGAATTCTGAGGGCTATAC	0.383													5	71					0	0	0	0	C	109897024	C	C	109897024	3	2	286	1	0	0	0	0	1	0	0	0	14999	1299	45	2	1886	2	SORT1	1	109897024	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	102111	109897024	139353597	8	53246											
HRNR	388697	broad.mit.edu	37	chr1	152187542	152187542	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgccccgaaccggacccaTgtcggccgcggctaggggaa	8	4	15	14	5	0	0	0	0	0	0	1	3	0	2	5	5	2	1	5	5	3	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:152187542T>C	uc001ezt.1	-	3	6639	c.6563A>G	c.(6562-6564)CAT>CGT	p.H2188R		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2188	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCGGACCCATGTCGGCCGCG	0.647													13	243					0	0	0	0	C	152187542	C	C	152187542	3	2	286	1	0	0	0	0	1	0	0	0	7398	1464	51	5	1993	5	HRNR	1	152187542	Missense_Mutation	SNP	T	TCGA-DQ-5630-01A-01D-1870-08	42290518	152187542	97063079	9	53247											
PRCC	5546	broad.mit.edu	37	chr1	156770249	156770249	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acccaagccaaatatggattCtagggctctggaactgattg	12	10	10	9	0	2	1	0	1	2	0	2	3	2	3	2	3	2	1	2	3	5	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:156770249C>T	uc001fqa.2	+	7	1763	c.1473C>T	c.(1471-1473)TTC>TTT	p.F491F	PRCC_uc001fqb.2_Silent_p.F459F	NM_005973	NP_005964	Q92733	PRCC_HUMAN	papillary renal cell carcinoma	491					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	kidney(25)|central_nervous_system(2)	27	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AATATGGATTCTAGGGCTCTG	0.597			T	TFE3	papillary renal 								11	83					0	0	0	0	T	156770249	T	T	156770249	2	4	286	1	0	0	0	0	0	0	0	1	12509	912	32	2		2	PRCC	1	156770249	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	4582707	156770249	92480372	10	53248											
ASTN1	460	broad.mit.edu	37	chr1	176993768	176993768	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggtgatcttgacaacgagAgggcagttgacgtgagagga	12	7	17	5	2	1	5	0	4	1	2	1	8	1	6	0	3	1	2	0	3	1	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:176993768A>T	uc001glc.2	-	6	1433	c.1221T>A	c.(1219-1221)CCT>CCA	p.P407P	ASTN1_uc001glb.1_Silent_p.P407P|ASTN1_uc001gld.1_Silent_p.P407P|ASTN1_uc009wwx.1_Silent_p.P407P|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	407					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TGACAACGAGAGGGCAGTTGA	0.537													5	36					0	0	0	0	T	176993768	T	T	176993768	2	4	286	1	0	0	0	0	0	0	0	1	1066	291	11	5		5	ASTN1	1	176993768	Silent	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	20223519	176993768	72256853	11	53249											
ETNK2	55224	broad.mit.edu	37	chr1	204115797	204115797	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatctcgttcttcacaagcGtgaaataattgtgcatcttg	10	15	8	8	2	4	2	1	2	3	0	5	2	4	2	0	0	2	2	0	0	3	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr1:204115797G>A	uc001hao.3	-	3	941	c.614C>T	c.(613-615)ACG>ATG	p.T205M	ETNK2_uc010pqr.1_Missense_Mutation_p.T27M|ETNK2_uc001han.3_Missense_Mutation_p.T205M|ETNK2_uc010pqs.1_Intron|ETNK2_uc010pqt.1_Missense_Mutation_p.T27M	NM_018208	NP_060678	Q9NVF9	EKI2_HUMAN	ethanolamine kinase 2	205							ATP binding|choline kinase activity|ethanolamine kinase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(21;0.032)|Breast(84;0.116)|all_epithelial(62;0.196)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			CTTCACAAGCGTGAAATAATT	0.502													11	94					0	0	0	0	A	204115797	A	A	204115797	3	1	286	1	0	0	0	0	1	0	0	0	5298	1145	40	1	570	1	ETNK2	1	204115797	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	27122029	204115797	45134824	12	53250											
C2orf89	129293	broad.mit.edu	37	chr2	85051178	85051178	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgttcggcctcactgggCgtgtcggcacttccaggccg	3	10	13	15	4	2	0	1	0	1	0	5	0	3	0	3	4	0	2	3	4	0	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr2:85051178C>T	uc010ysl.1	-	6	1322	c.1233G>A	c.(1231-1233)ACG>ACA	p.T411T	C2orf89_uc002sou.3_Silent_p.T362T	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	411	Extracellular (Potential).					integral to membrane				ovary(1)	1						CCTCACTGGGCGTGTCGGCAC	0.642													6	25					0	0	0	0	T	85051178	T	T	85051178	2	4	286	1	0	0	0	0	0	0	0	1	2213	755	27	1		1	C2orf89	2	85051178	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08		85051178	158148195	13	53251											
POLR1A	25885	broad.mit.edu	37	chr2	86258685	86258685	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccttccctgtggggatttCgttcctcctgcatgtcttca	4	15	8	14	1	2	0	1	0	1	0	6	1	5	1	4	2	1	2	4	2	0	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr2:86258685C>T	uc002sqs.2	-	30	4725	c.4346G>A	c.(4345-4347)CGA>CAA	p.R1449Q	POLR1A_uc010ytb.1_Missense_Mutation_p.R815Q	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1449					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GTGGGGATTTCGTtcctcctg	0.413													12	78					0	0	0	0	T	86258685	T	T	86258685	3	4	286	1	0	0	0	0	1	0	0	0	12264	884	31	1	836	1	POLR1A	2	86258685	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	1207507	86258685	156940688	14	53252											
IL1R2	7850	broad.mit.edu	37	chr2	102642600	102642600	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcagaaaataatgagaactaCattgaagtgccattgatttt	16	13	7	5	0	1	4	1	3	0	2	1	5	1	4	1	0	3	0	1	0	6	6			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr2:102642600C>T	uc002tbm.2	+	8	1144	c.915C>T	c.(913-915)TAC>TAT	p.Y305Y	IL1R2_uc002tbn.2_Silent_p.Y305Y	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	305	Extracellular (Potential).|Ig-like C2-type 3.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	ATGAGAACTACATTGAAGTGC	0.338													7	64					0	0	0	0	T	102642600	T	T	102642600	2	4	286	1	0	0	0	0	0	0	0	1	7698	489	17	4		4	IL1R2	2	102642600	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	16383915	102642600	140556773	15	53253											
TTN	7273	broad.mit.edu	37	chr2	179585124	179585128	+	Frame_Shift_Del	DEL	CAGAG	-	-																															atacaaacctttgaacttgaCagagcaagaacacgtgtcac																										TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr2:179585124_179585128delCAGAG	uc010zfg.1	-	77	19853_19857	c.19629_19633delCTCTG	c.(19627-19635)TGCTCTGTCfs	p.C6543fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.C3204fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7470_7472							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGAACTTGACAGAGCAAGAACACG	0.405													---	---	---								-	179585128	-	-	179585124	7	5	286	1	0	1	0	1	0	0	0	0	16803	478	17	0	81296	0	TTN	2	179585124	Frame_Shift_Del	DEL	CAGAG	TCGA-DQ-5630-01A-01D-1870-08	76942524	179585124	63614249	16	53254											
NOP58	51602	broad.mit.edu	37	chr2	203168128	203168128	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagtccagagaaaaagaagaAaaagaaaaaaaagagagaga	27	1	11	2	0	0	6	0	0	0	6	1	10	1	6	1	0	0	0	1	0	9	0			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr2:203168128A>G	uc002uzb.2	+	15	1709	c.1559A>G	c.(1558-1560)AAA>AGA	p.K520R		NM_015934	NP_057018	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein homolog	520	Lys-rich.				cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding				0						aaaaagaagaaaaagaaaaaa	0.328													10	57					0	0	0	0	G	203168128	G	G	203168128	3	3	286	1	0	0	0	0	1	0	0	0	10594	14	1	5	1617	5	NOP58	2	203168128	Missense_Mutation	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	23583004	203168128	40031245	17	53255											
WDR12	55759	broad.mit.edu	37	chr2	203764342	203764342	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtatacttctccacgtattCtatttccacaacttcttcct	9	17	2	13	1	3	0	0	0	3	0	6	0	5	0	3	0	2	2	3	0	5	9			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr2:203764342C>G	uc002uzl.2	-	4	1000	c.250G>C	c.(250-252)GAA>CAA	p.E84Q	WDR12_uc010ftt.2_Missense_Mutation_p.E84Q	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	84					cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						TCCACGTATTCTATTTCCACA	0.393													4	72					0	0	0	0	G	203764342	G	G	203764342	3	3	286	1	0	0	0	0	1	0	0	0	17342	922	32	2	1061	2	WDR12	2	203764342	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	596214	203764342	39435031	18	53256											
SH3BP4	23677	broad.mit.edu	37	chr2	235949576	235949576	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagacaaccccacacctttcGgaaatgcaaaggaagtgatt	15	8	8	10	1	0	2	0	1	0	1	1	4	0	4	3	2	2	1	3	2	5	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr2:235949576G>A	uc002vvp.2	+	4	556	c.163G>A	c.(163-165)GGA>AGA	p.G55R	SH3BP4_uc010fym.2_Missense_Mutation_p.G55R|SH3BP4_uc002vvq.2_Missense_Mutation_p.G55R	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	55	SH3.				endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CACACCTTTCGGAAATGCAAA	0.532													31	157					0	0	0	0	A	235949576	A	A	235949576	3	1	286	1	0	0	0	0	1	0	0	0	14311	1117	39	1	169	1	SH3BP4	2	235949576	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	32185234	235949576	7249797	19	53257											
AGAP1	116987	broad.mit.edu	37	chr2	236659046	236659046	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	catcgatgacgccagggcgaGgaagctctccaacgacctga	11	5	12	13	4	1	2	0	2	1	0	3	6	1	3	3	2	2	1	3	2	2	0			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr2:236659046G>A	uc002vvs.2	+	6	1182	c.587G>A	c.(586-588)AGG>AAG	p.R196K	AGAP1_uc002vvt.2_Missense_Mutation_p.R196K	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	196	Small GTPase-like.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						GCCAGGGCGAGGAAGCTCTCC	0.527													34	136					0	0	0	0	A	236659046	A	A	236659046	3	1	286	1	0	0	0	0	1	0	0	0	366	1000	35	4	609	4	AGAP1	2	236659046	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	709470	236659046	6540327	20	53258											
DNAH1	25981	broad.mit.edu	37	chr3	52380551	52380551	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggccatgcgcagcagcctgCgcgacatgagcaagggctgg	8	5	16	12	3	0	1	0	1	0	0	0	2	0	1	2	3	5	4	2	3	1	0			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr3:52380551C>T	uc011bef.1	+	11	1981	c.1720C>T	c.(1720-1722)CGC>TGC	p.R574C	DNAH1_uc003ddt.1_Missense_Mutation_p.R574C	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	574	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CAGCAGCCTGCGCGACATGAG	0.567													4	17					0	0	0	0	T	52380551	T	T	52380551	3	4	286	1	0	0	0	0	1	0	0	0	4619	768	27	1	1758	1	DNAH1	3	52380551	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08		52380551	145641879	21	53259											
OR5AC2	81050	broad.mit.edu	37	chr3	97806749	97806749	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagccttctccacatgcggcGcccatctgctttctgtctca	6	12	7	16	2	4	0	1	0	4	0	6	0	4	0	3	1	3	1	3	1	1	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr3:97806749G>A	uc011bgs.1	+	1	733	c.733G>A	c.(733-735)GCC>ACC	p.A245T		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CACATGCGGCGCCCATCTGCT	0.423													7	56					0	0	0	0	A	97806749	A	A	97806749	3	1	286	1	0	0	0	0	1	0	0	0	11195	1087	38	1	735	1	OR5AC2	3	97806749	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	45426198	97806749	100215681	22	53260											
NR1I2	8856	broad.mit.edu	37	chr3	119534276	119534276	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgatgcaggccatctccctCttctccccaggtgaggatct	6	11	9	15	0	4	2	0	2	4	0	6	3	4	3	4	3	1	1	4	3	0	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr3:119534276C>G	uc003edj.2	+	7	2883	c.1044C>G	c.(1042-1044)CTC>CTG	p.L348L	NR1I2_uc003edi.2_Silent_p.L311L|NR1I2_uc003edk.2_Silent_p.L387L|NR1I2_uc003edl.2_Silent_p.L236L	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	348	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	CCATCTCCCTCTTCTCCCCAG	0.567													8	76					0	0	0	0	G	119534276	G	G	119534276	2	3	286	1	0	0	0	0	0	0	0	1	10674	900	32	2		2	NR1I2	3	119534276	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	21727527	119534276	78488154	23	53261											
PARP14	54625	broad.mit.edu	37	chr3	122411306	122411306	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taatcttgttagtggagaacAtaagtggcctgtctaatgat	12	14	10	5	0	2	2	0	1	2	1	2	3	2	2	1	2	1	1	1	2	5	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr3:122411306A>G	uc003efq.3	+	4	573	c.514A>G	c.(514-516)ATA>GTA	p.I172V	PARP14_uc010hrk.2_5'Flank	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		AGTGGAGAACATAAGTGGCCT	0.363													14	65					0	0	0	0	G	122411306	G	G	122411306	3	3	286	1	0	0	0	0	1	0	0	0	11512	217	8	5	528	5	PARP14	3	122411306	Missense_Mutation	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	2877030	122411306	75611124	24	53262											
TOPBP1	11073	broad.mit.edu	37	chr3	133327412	133327412	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagcaatgtattctgttctCaagcagtacacgttctgggc	9	13	9	10	1	4	0	2	0	3	0	5	0	4	0	0	1	3	6	0	1	4	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr3:133327412C>G	uc003eps.2	-	27	4524	c.4392G>C	c.(4390-4392)TTG>TTC	p.L1464F		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	1464	BRCT 8.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						ATTCTGTTCTCAAGCAGTACA	0.393								Other_conserved_DNA_damage_response_genes					11	129					0	0	0	0	G	133327412	G	G	133327412	3	3	286	1	0	0	0	0	1	0	0	0	16436	825	29	2	184	2	TOPBP1	3	133327412	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	10916106	133327412	64695018	25	53263											
SHOX2	6474	broad.mit.edu	37	chr3	157820662	157820662	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcatcctctttgcgatctttCagctccggggacactggagg	6	11	12	12	2	3	0	1	0	2	0	5	3	5	2	2	4	2	2	2	4	0	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr3:157820662C>G	uc003fbr.2	-	2	499	c.360G>C	c.(358-360)CTG>CTC	p.L120L	SHOX2_uc003fbs.2_Silent_p.L144L|SHOX2_uc010hvw.2_Silent_p.L120L	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	120					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TGCGATCTTTCAGCTCCGGGG	0.483													6	73					0	0	0	0	G	157820662	G	G	157820662	2	3	286	1	0	0	0	0	0	0	0	1	14354	813	29	2		2	SHOX2	3	157820662	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	24493250	157820662	40201768	26	53264											
PIK3CA	5290	broad.mit.edu	37	chr3	178928073	178928073	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctttggccagtacctcatGgattagaagatttgctgaac	11	13	9	8	0	2	3	1	1	1	2	2	4	2	4	2	2	3	2	2	2	4	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr3:178928073G>A	uc003fjk.2	+	8	1508	c.1351G>A	c.(1351-1353)GGA>AGA	p.G451R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	451	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G451_L456>V(1)|p.P449_L455del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGTACCTCATGGATTAGAAGA	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			12	89					0	0	0	0	A	178928073	A	A	178928073	3	1	286	1	0	0	0	0	1	0	0	0	11968	1349	47	4	1377	4	PIK3CA	3	178928073	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	21107411	178928073	19094357	27	53265											
ACAP2	23527	broad.mit.edu	37	chr3	195041540	195041540	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttagaatcatcactggagaaAtcctacacaaaataacacat	19	9	4	9	0	2	2	2	0	0	2	3	3	3	2	1	1	2	0	1	1	7	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr3:195041540A>C	uc003fun.3	-	10	988	c.747T>G	c.(745-747)GAT>GAG	p.D249E		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	249					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						CACTGGAGAAATCCTACACAA	0.219													3	54					0	0	0	0	C	195041540	C	C	195041540	3	2	286	1	0	0	0	0	1	0	0	0	119	98	4	5	1645	5	ACAP2	3	195041540	Missense_Mutation	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	16113467	195041540	2980890	28	53266											
MUC4	4585	broad.mit.edu	37	chr3	195517410	195517410	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gataaaacagttgatgttgtAaccggtgtgagggtgttgag	11	12	15	3	1	0	3	0	3	0	0	0	4	0	3	1	2	2	4	1	2	3	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr3:195517410A>G	uc011bto.1	-	2	1501	c.1041T>C	c.(1039-1041)GTT>GTC	p.V347V	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Silent_p.V229V	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	352					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TTGATGTTGTAACCGGTGTGA	0.473													10	304					0	0	0	0	G	195517410	G	G	195517410	2	3	286	1	0	0	0	0	0	0	0	1	10031	349	13	5		5	MUC4	3	195517410	Silent	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	475870	195517410	2505020	29	53267											
MSX1	4487	broad.mit.edu	37	chr4	4864702	4864702	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaagcccatgctgccaccGgctgccttcggcctctcctt	4	9	9	19	2	1	0	0	0	1	0	3	0	1	0	7	2	4	2	7	2	1	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr4:4864702G>A	uc003gif.2	+	2	979	c.744G>A	c.(742-744)CCG>CCA	p.P248P		NM_002448	NP_002439	P28360	MSX1_HUMAN	msh homeobox 1	242					apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TGCTGCCACCGGCTGCCTTCG	0.672													4	26					0	0	0	0	A	4864702	A	A	4864702	2	1	286	1	0	0	0	0	0	0	0	1	9948	1103	39	1		1	MSX1	4	4864702	Silent	SNP	G	TCGA-DQ-5630-01A-01D-1870-08		4864702	186289574	30	53268											
FGF2	2247	broad.mit.edu	37	chr4	123797546	123797546	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgtgctaaccgttacctGgctatgaaggaagatggaag	11	10	14	6	1	0	2	0	1	0	1	0	4	0	4	2	3	3	3	2	3	6	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr4:123797546G>A	uc003iev.1	+	2	716	c.648G>A	c.(646-648)CTG>CTA	p.L216L		NM_002006	NP_001997	P09038	FGF2_HUMAN	fibroblast growth factor 2	216					activation of MAPK activity|branching involved in ureteric bud morphogenesis|cell migration involved in sprouting angiogenesis|chemotaxis|chondroblast differentiation|embryonic morphogenesis|fibroblast growth factor receptor signaling pathway|inositol phosphate biosynthetic process|insulin receptor signaling pathway|negative regulation of blood vessel endothelial cell migration|negative regulation of cell death|organ morphogenesis|phosphatidylinositol biosynthetic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cardiac muscle cell proliferation|positive regulation of cell division|positive regulation of cell fate specification|positive regulation of ERK1 and ERK2 cascade|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phospholipase C activity|Ras protein signal transduction|release of sequestered calcium ion into cytosol|wound healing	extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|lung(1)|central_nervous_system(1)	3					Pentosan Polysulfate(DB00686)	ACCGTTACCTGGCTATGAAGG	0.373													5	53					0	0	0	0	A	123797546	A	A	123797546	2	1	286	1	0	0	0	0	0	0	0	1	5880	1335	47	4		4	FGF2	4	123797546	Silent	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	118932844	123797546	67356730	31	53269											
TLR3	7098	broad.mit.edu	37	chr4	187004157	187004157	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctagaagtacttgacctgggCcttaatgaaattgggcaaga	13	10	11	7	0	0	4	0	2	0	2	0	4	0	4	2	2	1	2	2	2	6	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr4:187004157C>T	uc003iyq.2	+	4	1418	c.1317C>T	c.(1315-1317)GGC>GGT	p.G439G	TLR3_uc011ckz.1_Silent_p.G162G|TLR3_uc003iyr.2_Silent_p.G162G	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	439	LRR 16.|Lumenal (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TTGACCTGGGCCTTAATGAAA	0.408													12	42					0	0	0	0	T	187004157	T	T	187004157	2	4	286	1	0	0	0	0	0	0	0	1	16018	726	26	4		4	TLR3	4	187004157	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	63206611	187004157	4150119	32	53270											
FAM153A	285596	broad.mit.edu	37	chr5	177163583	177163583	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcccagaatacgtacattCggccagtgtgtctgggtccc	8	10	11	12	2	1	1	0	0	1	1	4	2	3	1	3	2	2	1	3	2	3	3	rs143733594		TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr5:177163583C>A	uc010jkp.1	-	13	851	c.430G>T	c.(430-432)GAA>TAA	p.E144*	FAM153A_uc011dgd.1_Intron|FAM153A_uc003mib.1_RNA|FAM153A_uc003mic.2_Nonsense_Mutation_p.E144*	NM_173663	NP_775934	Q9UHL3	F153A_HUMAN	hypothetical protein LOC285596	144								p.E144K(1)		skin(1)	1	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TACGTACATTCGGCCAGTGTG	0.458													4	71					0.00909568	0.00952071	1	0	A	177163583	A	A	177163583	4	1	286	1	0	0	0	0	0	1	0	0	5488	893	31	3	542	3	FAM153A	5	177163583	Nonsense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08		177163583	3751677	33	53271											
HIST1H2AA	221613	broad.mit.edu	37	chr6	25726721	25726721	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgagacttagacttggcgCgtgcttttcctccctgcttc	5	13	10	13	3	0	2	0	0	0	2	3	3	2	2	2	1	3	2	2	1	1	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr6:25726721C>T	uc003nfc.2	-	1	70	c.35G>A	c.(34-36)CGC>CAC	p.R12H	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	12					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGACTTGGCGCGTGCTTTTCC	0.527													11	62					0	0	0	0	T	25726721	T	T	25726721	3	4	286	1	0	0	0	0	1	0	0	0	7167	768	27	1	364	1	HIST1H2AA	6	25726721	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08		25726721	145388346	34	53272											
HIST1H4B	8366	broad.mit.edu	37	chr6	26027283	26027283	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taggtcacggcgtcccggatCacgttctccagaaacacctt	9	9	9	14	4	3	1	2	0	1	1	5	2	4	2	3	3	1	1	3	3	2	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr6:26027283C>T	uc003nfr.2	-	1	198	c.198G>A	c.(196-198)GTG>GTA	p.V66V		NM_003544	NP_003535	P62805	H4_HUMAN	histone cluster 1, H4b	66					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						CGTCCCGGATCACGTTCTCCA	0.572											OREG0017238	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	70					0	0	0	0	T	26027283	T	T	26027283	2	4	286	1	0	0	0	0	0	0	0	1	7205	813	29	2		2	HIST1H4B	6	26027283	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	300562	26027283	145087784	35	53273											
HTR1B	3351	broad.mit.edu	37	chr6	78172633	78172633	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcatgaccgccgccctcttgGgagtccttttagctgagtac	6	12	10	13	2	2	2	1	2	1	0	3	3	3	3	4	1	2	2	4	1	2	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr6:78172633G>A	uc003pil.1	-	1	488	c.488C>T	c.(487-489)CCC>CTC	p.P163L		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	163	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	CGCCCTCTTGGGAGTCCTTTT	0.602													4	47					0	0	0	0	A	78172633	A	A	78172633	3	1	286	1	0	0	0	0	1	0	0	0	7476	1232	43	4	688	4	HTR1B	6	78172633	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	52145350	78172633	92942434	36	53274											
CASP8AP2	9994	broad.mit.edu	37	chr6	90578310	90578310	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacttgggatgtggggtgatAcaggtagatgaagataattg	12	11	16	2	0	0	4	0	2	0	2	0	6	0	5	0	4	1	1	0	4	4	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr6:90578310A>T	uc003pnr.2	+	8	5497	c.5301A>T	c.(5299-5301)ATA>ATT	p.I1767I	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Silent_p.I1767I|CASP8AP2_uc011dzz.1_Silent_p.I1767I	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1767	NCOA2-binding.				cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		GTGGGGTGATACAGGTAGATG	0.403													6	34					0	0	0	0	T	90578310	T	T	90578310	2	4	286	1	0	0	0	0	0	0	0	1	2690	381	14	5		5	CASP8AP2	6	90578310	Silent	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	12405677	90578310	80536757	37	53275											
EPB41L2	2037	broad.mit.edu	37	chr6	131206332	131206332	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggcaatgctgacaagtccAggtccataggctgaaatctc	12	8	10	11	1	1	2	0	2	1	0	4	2	3	2	2	3	1	3	2	3	4	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr6:131206332A>G	uc003qch.2	-	12	1919	c.1737T>C	c.(1735-1737)CCT>CCC	p.P579P	EPB41L2_uc003qce.1_5'Flank|EPB41L2_uc003qcf.1_5'Flank|EPB41L2_uc003qcg.1_Silent_p.P579P|EPB41L2_uc011eby.1_Silent_p.P579P|EPB41L2_uc003qci.2_Silent_p.P579P|EPB41L2_uc010kfk.2_Silent_p.P579P|EPB41L2_uc010kfl.1_Silent_p.P579P	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	579	Hydrophilic.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TGACAAGTCCAGGTCCATAGG	0.493											OREG0017660	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	153					0	0	0	0	G	131206332	G	G	131206332	2	3	286	1	0	0	0	0	0	0	0	1	5177	175	7	5		5	EPB41L2	6	131206332	Silent	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	40628022	131206332	39908735	38	53276											
MED23	9439	broad.mit.edu	37	chr6	131915244	131915244	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caataaaaaggatattatcgActagtctgccaatcaatctg	16	11	6	8	1	3	0	1	0	2	0	4	2	3	1	1	1	1	0	1	1	9	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr6:131915244A>G	uc003qcs.1	-	23	3401	c.3227T>C	c.(3226-3228)GTC>GCC	p.V1076A	MED23_uc003qcq.2_Missense_Mutation_p.V1082A|MED23_uc003qcr.1_5'Flank|MED23_uc011eca.1_Missense_Mutation_p.V717A	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	1076					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		GATATTATCGACTAGTCTGCC	0.318													4	47					0	0	0	0	G	131915244	G	G	131915244	3	3	286	1	0	0	0	0	1	0	0	0	9494	275	10	5	914	5	MED23	6	131915244	Missense_Mutation	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	708912	131915244	39199823	39	53277											
KIAA1244	57221	broad.mit.edu	37	chr6	138576730	138576730	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggatcaggctgctcctgcActgcgccggccctgagcgga	6	6	15	14	3	1	1	1	1	0	0	2	4	2	3	3	4	4	3	3	4	0	0			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr6:138576730A>G	uc003qhu.2	+	10	928	c.928A>G	c.(928-930)ACT>GCT	p.T310A		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	310					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CTGCTCCTGCACTGCGCCGGC	0.642													9	77					0	0	0	0	G	138576730	G	G	138576730	3	3	286	1	0	0	0	0	1	0	0	0	8256	159	6	5	966	5	KIAA1244	6	138576730	Missense_Mutation	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	6661486	138576730	32538337	40	53278											
STX11	8676	broad.mit.edu	37	chr6	144508521	144508521	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agctcaacgtacaaaagacgGtcgactacaccggccaggcc	13	4	10	14	4	1	1	1	0	0	1	2	2	1	1	3	3	4	2	3	3	5	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr6:144508521G>A	uc003qks.3	+	2	949	c.757G>A	c.(757-759)GTC>ATC	p.V253I		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	253	t-SNARE coiled-coil homology.				cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		ACAAAAGACGGTCGACTACAC	0.627									Familial_Hemophagocytic_Lymphohistiocytosis				4	30					0	0	0	0	A	144508521	A	A	144508521	3	1	286	1	0	0	0	0	1	0	0	0	15403	1261	44	4	759	4	STX11	6	144508521	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	5931791	144508521	26606546	41	53279											
ACAT2	39	broad.mit.edu	37	chr6	160199708	160199708	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	taggtcaatattgaaggaggGgctatagccttgggccaccc	10	9	13	9	0	1	1	1	1	0	0	1	2	1	2	3	5	1	1	3	5	6	6			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr6:160199708G>A	uc010kjy.2	+	9	1172	c.1041G>A	c.(1039-1041)GGG>GGA	p.G347G	ACAT2_uc011efw.1_Silent_p.G376G|TCP1_uc003qsr.2_3'UTR|TCP1_uc003qss.2_3'UTR|TCP1_uc010kjz.2_3'UTR|TCP1_uc003qst.2_3'UTR	NM_005891	NP_005882	Q9BWD1	THIC_HUMAN	acetyl-Coenzyme A acetyltransferase 2	347						mitochondrion|nucleolus	acetyl-CoA C-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.51e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TTGAAGGAGGGGCTATAGCCT	0.443													16	109					0	0	0	0	A	160199708	A	A	160199708	2	1	286	1	0	0	0	0	0	0	0	1	122	1219	43	4		4	ACAT2	6	160199708	Silent	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	15691187	160199708	10915359	42	53280											
NEUROD6	63974	broad.mit.edu	37	chr7	31378675	31378675	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttctaggcaacccattttCatcttcctcttccctgtctt	5	17	3	16	0	5	0	1	0	4	0	7	0	7	0	4	1	1	1	4	1	2	7			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr7:31378675C>A	uc003tch.2	-	2	561	c.208G>T	c.(208-210)GAA>TAA	p.E70*		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	70					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						AACCCAttttcatcttcctct	0.358													24	169					5.35356e-11	6.18143e-11	1	0	A	31378675	A	A	31378675	4	1	286	1	0	0	0	0	0	1	0	0	10405	835	29	2	809	2	NEUROD6	7	31378675	Nonsense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08		31378675	127759988	43	53281											
DBNL	28988	broad.mit.edu	37	chr7	44100510	44100510	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaactacgtggagctcattGagtgaggctgagggcacatc	10	8	13	10	1	1	3	1	3	0	0	2	4	1	4	1	3	3	3	1	3	2	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr7:44100510G>C	uc003tjp.3	+	13	1386	c.1288G>C	c.(1288-1290)GAG>CAG	p.E430Q	DBNL_uc003tjo.3_Missense_Mutation_p.E431Q|DBNL_uc003tjr.3_Missense_Mutation_p.E303Q|DBNL_uc003tjq.3_Missense_Mutation_p.E439Q|DBNL_uc011kbm.1_Missense_Mutation_p.E406Q|DBNL_uc011kbn.1_Missense_Mutation_p.E327Q|DBNL_uc011kbo.1_Missense_Mutation_p.E331Q|DBNL_uc011kbp.1_Missense_Mutation_p.E382Q|DBNL_uc011kbq.1_Missense_Mutation_p.E355Q|DBNL_uc011kbr.1_Missense_Mutation_p.E379Q|DBNL_uc011kbs.1_Missense_Mutation_p.E335Q	NM_001014436	NP_001014436	Q9UJU6	DBNL_HUMAN	drebrin-like isoform b	430	SH3.			E -> D (in Ref. 6; CAG33448).	activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			skin(1)	1						GGAGCTCATTGAGTGAGGCTG	0.572													3	21					0	0	0	0	C	44100510	C	C	44100510	3	2	286	1	0	0	0	0	1	0	0	0	4272	1291	45	2	1365	2	DBNL	7	44100510	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	12721835	44100510	115038153	44	53282											
GRB10	2887	broad.mit.edu	37	chr7	50674050	50674050	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttaccactggcgtcgagaacGgggacagcaaggccttcctc	9	7	12	13	3	0	1	0	0	0	1	3	3	1	2	3	4	3	1	3	4	3	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr7:50674050G>A	uc003tpi.2	-	11	1287	c.1256C>T	c.(1255-1257)CCG>CTG	p.P419L	GRB10_uc003tph.3_Missense_Mutation_p.P361L|GRB10_uc003tpj.2_Missense_Mutation_p.P373L|GRB10_uc003tpk.2_Missense_Mutation_p.P419L|GRB10_uc010kzb.2_Missense_Mutation_p.P361L|GRB10_uc003tpl.2_Missense_Mutation_p.P413L|GRB10_uc003tpm.2_Missense_Mutation_p.P361L|GRB10_uc003tpn.2_Missense_Mutation_p.P361L	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	419					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					CGTCGAGAACGGGGACAGCAA	0.527									Russell-Silver_syndrome				17	97					0	0	0	0	A	50674050	A	A	50674050	3	1	286	1	0	0	0	0	1	0	0	0	6795	1116	39	1	552	1	GRB10	7	50674050	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	6573540	50674050	108464613	45	53283											
ABCB1	5243	broad.mit.edu	37	chr7	87229508	87229508	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcaagatccattccgaccTgaagagaaaccgcagctcat	13	8	7	13	2	2	3	2	1	0	2	4	5	4	3	4	0	2	2	4	0	3	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr7:87229508T>C	uc003uiz.1	-	3	413	c.-5_splice	c.e3-1		ABCB1_uc011khc.1_Splice_Site|ABCB1_uc003uja.1_Intron|ABCB1_uc010lei.1_Intron	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1						G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CATTCCGACCTGAAGAGAAAC	0.468													3	22					0	0	0	0	C	87229508	C	C	87229508	5	2	286	1	0	0	0	0	0	0	1	0	40	1594	55	5		5	ABCB1	7	87229508	Splice_Site	SNP	T	TCGA-DQ-5630-01A-01D-1870-08	36555458	87229508	71909155	46	53284											
DOCK4	9732	broad.mit.edu	37	chr7	111368416	111368416	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attctccaggtggctggatcGcgctgccagaggcttggggg	5	9	17	10	2	1	1	0	0	1	1	3	2	1	2	2	6	1	3	2	6	0	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr7:111368416G>A	uc003vfx.2	-	52	6084	c.5815C>T	c.(5815-5817)CGA>TGA	p.R1939*	DOCK4_uc011kml.1_Nonsense_Mutation_p.R820*|DOCK4_uc011kmm.1_Nonsense_Mutation_p.R808*|DOCK4_uc003vfw.2_Nonsense_Mutation_p.R1351*|DOCK4_uc003vfy.2_Nonsense_Mutation_p.R1984*|DOCK4_uc003vfv.2_Nonsense_Mutation_p.R252*	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1939	Pro-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TGGCTGGATCGCGCTGCCAGA	0.692													6	38					0	0	0	0	A	111368416	A	A	111368416	4	1	286	1	0	0	0	0	0	1	0	0	4711	1095	38	1	89	1	DOCK4	7	111368416	Nonsense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	24138908	111368416	47770247	47	53285											
FEZF1	389549	broad.mit.edu	37	chr7	121942271	121942271	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaaacccttgccgcacgtgGggcaggtgaaaggcttcttg	9	8	14	10	2	1	2	0	1	1	1	1	2	1	2	2	4	2	3	2	4	2	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr7:121942271G>A	uc003vkd.2	-	4	1282	c.1208C>T	c.(1207-1209)CCC>CTC	p.P403L	FEZF1_uc003vkc.2_Missense_Mutation_p.P353L|uc010lko.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	403	C2H2-type 6.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						GCCGCACGTGGGGCAGGTGAA	0.562													20	112					0	0	0	0	A	121942271	A	A	121942271	3	1	286	1	0	0	0	0	1	0	0	0	5857	1232	43	4	223	4	FEZF1	7	121942271	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	10573855	121942271	37196392	48	53286											
PXDNL	137902	broad.mit.edu	37	chr8	52322037	52322037	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacaccggttggagcagtttGgcagaggcctgcgagctgtg	8	8	16	9	2	0	1	0	0	0	1	0	3	0	2	2	4	4	5	2	4	1	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr8:52322037G>T	uc003xqu.3	-	17	2248	c.2147C>A	c.(2146-2148)CCA>CAA	p.P716Q	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	716					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GGAGCAGTTTGGCAGAGGCCT	0.622													12	27					7.03913e-09	7.96346e-09	1	0	T	52322037	T	T	52322037	3	4	286	1	0	0	0	0	1	0	0	0	12913	1348	47	4	2272	4	PXDNL	8	52322037	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08		52322037	94041985	49	53287											
GRHL2	79977	broad.mit.edu	37	chr8	102589743	102589743	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgaagcagagggtccttgaCattggtaagttgaccttgac	10	10	13	8	1	0	4	0	3	0	1	1	5	1	4	2	2	1	3	2	2	2	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr8:102589743C>T	uc010mbu.2	+	7	1329	c.999C>T	c.(997-999)GAC>GAT	p.D333D		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	333						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			GGGTCCTTGACATTGGTAAGT	0.483													7	83					0	0	0	0	T	102589743	T	T	102589743	2	4	286	1	0	0	0	0	0	0	0	1	6803	477	17	4		4	GRHL2	8	102589743	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	50267706	102589743	43774279	50	53288											
ZHX1	11244	broad.mit.edu	37	chr8	124266308	124266308	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atctatttccattttctcttCctttaaagcttttgatttct	7	23	2	9	0	3	1	0	1	3	0	6	1	5	1	2	0	1	1	2	0	3	10			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr8:124266308C>G	uc003yqe.2	-	3	2309	c.1879G>C	c.(1879-1881)GAA>CAA	p.E627Q	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.E627Q|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.E627Q	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	627	Homeobox 3.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			ATTTTCTCTTCCTTTAAAGCT	0.383													3	61					0	0	0	0	G	124266308	G	G	124266308	3	3	286	1	0	0	0	0	1	0	0	0	17742	864	30	2	746	2	ZHX1	8	124266308	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	21676565	124266308	22097714	51	53289											
IFNA4	3441	broad.mit.edu	37	chr9	21187444	21187444	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcctattacccaggctgtgGgtctgaggcagatcacagcc	8	9	11	13	0	2	2	1	1	1	1	3	2	3	2	3	3	2	2	3	3	2	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr9:21187444G>A	uc003zon.2	-	1	155	c.87C>T	c.(85-87)ACC>ACT	p.T29T		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	29					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CCAGGCTGTGGGTCTGAGGCA	0.512													5	85					0	0	0	0	A	21187444	A	A	21187444	2	1	286	1	0	0	0	0	0	0	0	1	7578	1219	43	4		4	IFNA4	9	21187444	Silent	SNP	G	TCGA-DQ-5630-01A-01D-1870-08		21187444	120025987	52	53290											
ACO1	48	broad.mit.edu	37	chr9	32448924	32448924	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccgtcctggccgagagctacGagcgcattcaccgcagtaac	9	6	11	15	5	1	1	1	0	0	1	2	3	2	1	4	1	4	4	4	1	2	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr9:32448924G>C	uc003zqw.3	+	20	2556	c.2401G>C	c.(2401-2403)GAG>CAG	p.E801Q	ACO1_uc003zqx.3_Missense_Mutation_p.E801Q|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	801					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		CGAGAGCTACGAGCGCATTCA	0.488													4	61					0	0	0	0	C	32448924	C	C	32448924	3	2	286	1	0	0	0	0	1	0	0	0	146	1059	37	3	2475	3	ACO1	9	32448924	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	11261480	32448924	108764507	53	53291											
TAF1L	138474	broad.mit.edu	37	chr9	32634244	32634244	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcttgcaccctgaggttttGtccctttgtgtttgatatcc	4	17	10	10	0	0	2	0	2	0	0	2	2	2	2	3	2	1	4	3	2	1	6			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr9:32634244G>C	uc003zrg.1	-	1	1424	c.1334C>G	c.(1333-1335)ACA>AGA	p.T445R	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	445					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CTGAGGTTTTGTCCCTTTGTG	0.483													11	180					0	0	0	0	C	32634244	C	C	32634244	3	2	286	1	0	0	0	0	1	0	0	0	15589	1377	48	4	4150	4	TAF1L	9	32634244	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	185320	32634244	108579187	54	53292											
HIATL1	84641	broad.mit.edu	37	chr9	97218593	97218593	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcaatcagtgccctcgtctCtcggaatgcagagtcagatc	9	9	11	12	2	3	2	2	0	1	2	7	3	3	3	1	2	2	2	1	2	2	0			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr9:97218593C>G	uc004aur.2	+	10	1369	c.1100C>G	c.(1099-1101)TCT>TGT	p.S367C	HIATL1_uc011luh.1_Intron	NM_032558	NP_115947	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	367	Extracellular (Potential).			S -> T (in Ref. 3; BAB55274).	transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				GCCCTCGTCTCTCGGAATGCA	0.577													4	80					0	0	0	0	G	97218593	G	G	97218593	3	3	286	1	0	0	0	0	1	0	0	0	7137	913	32	2	1138	2	HIATL1	9	97218593	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	64584349	97218593	43994838	55	53293											
ZFP37	7539	broad.mit.edu	37	chr9	115818942	115818942	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acggtctctggctttgtcagAatctggacgccgctggagac	7	10	13	11	3	3	2	1	0	2	2	4	4	3	3	1	4	0	2	1	4	1	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr9:115818942A>C	uc004bgm.1	-	1	55	c.27T>G	c.(25-27)ATT>ATG	p.I9M	ZFP37_uc011lwz.1_Missense_Mutation_p.I9M|ZFP37_uc011lxa.1_Missense_Mutation_p.I9M	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	9						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GCTTTGTCAGAATCTGGACGC	0.682													9	63					0	0	0	0	C	115818942	C	C	115818942	3	2	286	1	0	0	0	0	1	0	0	0	17715	242	9	5	1881	5	ZFP37	9	115818942	Missense_Mutation	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	18600349	115818942	25394489	56	53294											
BRD3	8019	broad.mit.edu	37	chr9	136917540	136917540	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taatagtccccatatccattGggtttttaattattttatga	11	19	5	6	0	0	1	0	1	0	0	2	1	2	1	3	1	0	1	3	1	6	10			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr9:136917540G>A	uc004cew.2	-	3	427	c.239C>T	c.(238-240)CCA>CTA	p.P80L	BRD3_uc004cex.2_Missense_Mutation_p.P80L	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	80	Bromo 1.					nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		CATATCCATTGGGTTTTTAAT	0.333			T	NUT|C15orf55	lethal midline carcinoma of young people								5	66					0	0	0	0	A	136917540	A	A	136917540	3	1	286	1	0	0	0	0	1	0	0	0	1508	1348	47	4	1981	4	BRD3	9	136917540	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	21098598	136917540	4295891	57	53295											
KIAA1462	57608	broad.mit.edu	37	chr10	30336618	30336618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctcatgcccgttctgcaggcCctggcctgctcgtgtcccag	3	10	11	17	2	2	0	1	0	1	0	4	0	3	0	4	2	3	3	4	2	0	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr10:30336618C>T	uc001iux.2	-	1	183	c.124G>A	c.(124-126)GGC>AGC	p.G42S	KIAA1462_uc001iuy.2_Missense_Mutation_p.G42S|KIAA1462_uc001iuz.2_5'UTR|KIAA1462_uc009xle.1_Missense_Mutation_p.G42S	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	42										ovary(4)	4						TTCTGCAGGCCCTGGCCTGCT	0.637													7	47					0	0	0	0	T	30336618	T	T	30336618	3	4	286	1	0	0	0	0	1	0	0	0	8273	623	22	4	3967	4	KIAA1462	10	30336618	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08		30336618	105198129	58	53296											
ANK3	288	broad.mit.edu	37	chr10	61836161	61836161	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagaaaagaatggcttgtatGagtaagtggtggggagggat	13	10	17	1	0	0	3	0	1	0	2	0	5	0	5	0	5	0	3	0	5	6	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr10:61836161G>A	uc001jky.2	-	37	4670	c.4478C>T	c.(4477-4479)TCA>TTA	p.S1493L	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron|ANK3_uc009xpc.1_RNA	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1493					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TGGCTTGTATGAGTAAGTGGT	0.418													8	36					0	0	0	0	A	61836161	A	A	61836161	3	1	286	1	0	0	0	0	1	0	0	0	622	1294	45	2	8996	2	ANK3	10	61836161	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	31499543	61836161	73698586	59	53297											
TDRD1	56165	broad.mit.edu	37	chr10	115980379	115980379	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagccataacaagattccaGatgtgtgttgctgggataaa	14	10	11	6	0	0	2	0	0	0	2	1	4	1	3	2	1	3	2	2	1	5	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr10:115980379G>A	uc001lbg.1	+	19	2700	c.2547G>A	c.(2545-2547)CAG>CAA	p.Q849Q	TDRD1_uc001lbf.2_Silent_p.Q726Q|TDRD1_uc001lbh.1_Silent_p.Q840Q|TDRD1_uc001lbi.1_Silent_p.Q840Q|TDRD1_uc010qsc.1_Silent_p.Q453Q|TDRD1_uc001lbj.2_Silent_p.Q558Q	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	849					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		CAAGATTCCAGATGTGTGTTG	0.388													4	78					0	0	0	0	A	115980379	A	A	115980379	2	1	286	1	0	0	0	0	0	0	0	1	15796	933	33	2		2	TDRD1	10	115980379	Silent	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	54144218	115980379	19554368	60	53298											
B4GALNT4	338707	broad.mit.edu	37	chr11	379925	379925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatggctgcgctgcacgcgCgcaccggggactcgcgtttc	5	7	14	15	7	0	0	0	0	0	0	2	1	0	1	1	3	2	5	1	3	0	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr11:379925C>T	uc001lpb.2	+	16	2557	c.2548C>T	c.(2548-2550)CGC>TGC	p.R850C		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	850	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCTGCACGCGCGCACCGGGGA	0.687													6	51					0	0	0	0	T	379925	T	T	379925	3	4	286	1	0	0	0	0	1	0	0	0	1271	768	27	1	2610	1	B4GALNT4	11	379925	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08		379925	134626591	61	53299											
TRIM22	10346	broad.mit.edu	37	chr11	5730360	5730360	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagacaagtgaaaactgtaCgcacctgcacatttaagaat	17	8	8	8	1	0	3	0	1	0	2	0	4	0	3	1	0	3	3	1	0	6	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr11:5730360C>T	uc001mbr.2	+	8	1256	c.979C>T	c.(979-981)CGC>TGC	p.R327C	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.2_Missense_Mutation_p.R323C|TRIM22_uc010qzm.1_Missense_Mutation_p.R155C|TRIM22_uc009yeu.2_Missense_Mutation_p.R138C|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	327	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		GAAAACTGTACGCACCTGCAC	0.413													8	79					0	0	0	0	T	5730360	T	T	5730360	3	4	286	1	0	0	0	0	1	0	0	0	16563	536	19	1	1005	1	TRIM22	11	5730360	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	5350435	5730360	129276156	62	53300											
ELF5	2001	broad.mit.edu	37	chr11	34515223	34515223	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acacatggcgcttagtccagTattcagggtggactgatgtc	9	11	12	9	1	1	1	1	1	0	0	3	2	2	2	1	3	0	2	1	3	2	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr11:34515223T>C	uc001mvo.1	-	3	418	c.188A>G	c.(187-189)TAC>TGC	p.Y63C	ELF5_uc001mvp.1_Missense_Mutation_p.Y53C|ELF5_uc009ykd.1_Intron|ELF5_uc001mvq.1_Missense_Mutation_p.Y53C	NM_198381	NP_938195	Q9UKW6	ELF5_HUMAN	E74-like factor 5 ESE-2a	63	PNT.				cell proliferation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.0087)|all_hematologic(20;0.0384)				CTTAGTCCAGTATTCAGGGTG	0.532											OREG0020879	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	29					0	0	0	0	C	34515223	C	C	34515223	3	2	286	1	0	0	0	0	1	0	0	0	5081	1638	57	5	629	5	ELF5	11	34515223	Missense_Mutation	SNP	T	TCGA-DQ-5630-01A-01D-1870-08	28784863	34515223	100491293	63	53301											
OR8I2	120586	broad.mit.edu	37	chr11	55861330	55861330	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttgtgacaccacagctCttttagcactctcctgtgta	7	17	6	11	0	2	1	0	1	2	0	3	1	2	1	2	0	2	3	2	0	2	6			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr11:55861330C>A	uc010rix.1	+	1	547	c.547C>A	c.(547-549)CTT>ATT	p.L183I		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					CACCACAGCTCTTTTAGCACT	0.438													15	118					2.31682e-05	2.54396e-05	1	0	A	55861330	A	A	55861330	3	1	286	1	0	0	0	0	1	0	0	0	11294	913	32	2	549	2	OR8I2	11	55861330	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	21346107	55861330	79145186	64	53302											
HEPHL1	341208	broad.mit.edu	37	chr11	93778850	93778850	+	Nonsense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tacttttagacttgcaacctTatttctcgaaagagggccca	11	13	7	10	1	1	2	0	0	1	2	2	3	1	2	2	1	3	1	2	1	5	6			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr11:93778850T>G	uc001pep.2	+	2	339	c.182T>G	c.(181-183)TTA>TGA	p.L61*		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	61	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CTTGCAACCTTATTTCTCGAA	0.348													3	16					0	0	0	0	G	93778850	G	G	93778850	4	3	286	1	0	0	0	0	0	1	0	0	7094	1764	61	5	188	5	HEPHL1	11	93778850	Nonsense_Mutation	SNP	T	TCGA-DQ-5630-01A-01D-1870-08	37917520	93778850	41227666	65	53303											
KCNJ8	3764	broad.mit.edu	37	chr12	21926400	21926400	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagaaagcgtccttgctcacGgatgttcttatgcgccaggt	8	12	11	10	3	2	1	1	0	1	1	3	2	3	2	2	2	3	2	2	2	3	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr12:21926400G>A	uc001rff.2	-	2	489	c.151C>T	c.(151-153)CGT>TGT	p.R51C		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	51	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	CCTTGCTCACGGATGTTCTTA	0.602											OREG0021704	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	73					0	0	0	0	A	21926400	A	A	21926400	3	1	286	1	0	0	0	0	1	0	0	0	8095	1116	39	1	1131	1	KCNJ8	12	21926400	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08		21926400	111925495	66	53304											
LARP4	113251	broad.mit.edu	37	chr12	50822793	50822793	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcttgtgaaaccacaagaaAtactacaggcattgaagaat	18	9	7	7	0	1	4	0	2	1	2	1	4	1	4	1	1	3	1	1	1	7	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr12:50822793A>G	uc001rwp.1	+	3	386	c.242A>G	c.(241-243)AAT>AGT	p.N81S	LARP4_uc001rwo.1_Missense_Mutation_p.N87S|LARP4_uc001rwq.1_Missense_Mutation_p.N81S|LARP4_uc001rwr.1_Missense_Mutation_p.N81S|LARP4_uc001rws.1_Missense_Mutation_p.N80S|LARP4_uc001rwm.2_Missense_Mutation_p.N81S|LARP4_uc001rwn.2_Missense_Mutation_p.N11S	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	81							nucleotide binding|RNA binding			ovary(1)	1						ACCACAAGAAATACTACAGGC	0.333													10	78					0	0	0	0	G	50822793	G	G	50822793	3	3	286	1	0	0	0	0	1	0	0	0	8670	101	4	5	252	5	LARP4	12	50822793	Missense_Mutation	SNP	A	TCGA-DQ-5630-01A-01D-1870-08	28896393	50822793	83029102	67	53305											
OSBPL8	114882	broad.mit.edu	37	chr12	76750470	76750470	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgaatgtctcccagttctaTtcctttctttcttcttgtac	5	20	4	12	0	5	1	0	1	5	0	7	1	6	1	2	0	1	2	2	0	3	8			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr12:76750470T>C	uc001sye.1	-	23	2953	c.2473A>G	c.(2473-2475)ATA>GTA	p.I825V	OSBPL8_uc001syf.1_Missense_Mutation_p.I783V|OSBPL8_uc001syg.1_Missense_Mutation_p.I783V	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	825					lipid transport		lipid binding			ovary(1)	1						CCCAGTTCTATTCCTTTCTTT	0.294													12	70					0	0	0	0	C	76750470	C	C	76750470	3	2	286	1	0	0	0	0	1	0	0	0	11337	1493	52	5	204	5	OSBPL8	12	76750470	Missense_Mutation	SNP	T	TCGA-DQ-5630-01A-01D-1870-08	25927677	76750470	57101425	68	53306											
LCP1	3936	broad.mit.edu	37	chr13	46732708	46732708	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgctctgaagtaccaccgaTtgcacaaatcccttccttct	9	12	5	15	1	2	1	0	1	2	0	4	2	4	1	4	0	3	3	4	0	3	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr13:46732708T>A	uc001vaz.3	-	4	433	c.307A>T	c.(307-309)ATC>TTC	p.I103F	LCP1_uc001vba.3_Missense_Mutation_p.I103F	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	103					regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		GTACCACCGATTGCACAAATC	0.423			T	BCL6	NHL 								20	65					0	0	0	0	A	46732708	A	A	46732708	3	1	286	1	0	0	0	0	1	0	0	0	8731	1493	52	5	1628	5	LCP1	13	46732708	Missense_Mutation	SNP	T	TCGA-DQ-5630-01A-01D-1870-08		46732708	68437170	69	53307											
KIAA0391	9692	broad.mit.edu	37	chr14	35735973	35735973	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	actagccaaacggaatctgcGactgctggtcctaggccgga	10	7	12	12	3	1	0	0	0	1	0	2	3	2	2	3	4	4	1	3	4	4	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr14:35735973G>C	uc001wsy.1	+	6	1676	c.1316G>C	c.(1315-1317)CGA>CCA	p.R439P	KIAA0391_uc010tps.1_Missense_Mutation_p.R344P|KIAA0391_uc001wsz.1_Missense_Mutation_p.R423P|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Missense_Mutation_p.R423P|KIAA0391_uc001wtc.1_Missense_Mutation_p.R67P	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	439					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		CGGAATCTGCGACTGCTGGTC	0.478													3	177					0	0	0	0	C	35735973	C	C	35735973	3	2	286	1	0	0	0	0	1	0	0	0	8211	1058	37	3	1334	3	KIAA0391	14	35735973	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08		35735973	71613567	70	53308											
INSM2	84684	broad.mit.edu	37	chr14	36004166	36004166	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaggtgaccacatcccctgtCctgggcctgaagatcaagga	10	7	12	12	0	1	3	1	2	0	1	3	5	3	4	5	3	0	0	5	3	2	0			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr14:36004166C>T	uc001wth.1	+	1	919	c.708C>T	c.(706-708)GTC>GTT	p.V236V		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	236					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		CATCCCCTGTCCTGGGCCTGA	0.662													8	23					0	0	0	0	T	36004166	T	T	36004166	2	4	286	1	0	0	0	0	0	0	0	1	7811	842	30	2		2	INSM2	14	36004166	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	268193	36004166	71345374	71	53309											
PSMC1	5700	broad.mit.edu	37	chr14	90730032	90730032	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatcaaaagtggatgatctGagggggaccccgatgtcagt	12	8	14	7	1	3	3	2	2	1	1	3	6	3	5	2	3	0	0	2	3	2	0			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr14:90730032G>C	uc001xyf.2	+	5	354	c.306G>C	c.(304-306)CTG>CTC	p.L102L	PSMC1_uc001xyg.2_Silent_p.L29L|PSMC1_uc001xyh.2_Silent_p.L29L|PSMC1_uc010twh.1_Silent_p.L29L	NM_002802	NP_002793	P62191	PRS4_HUMAN	proteasome 26S ATPase subunit 1	102					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0		all_cancers(154;0.142)		COAD - Colon adenocarcinoma(157;0.21)		TGGATGATCTGAGGGGGACCC	0.443													9	71					0	0	0	0	C	90730032	C	C	90730032	2	2	286	1	0	0	0	0	0	0	0	1	12747	1277	45	2		2	PSMC1	14	90730032	Silent	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	54725866	90730032	16619508	72	53310											
MEIS2	4212	broad.mit.edu	37	chr15	37184422	37184422	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccaacattgggatctacAgaatttaacattgtggggct	11	11	10	9	1	1	1	0	0	1	1	1	2	1	2	2	3	3	1	2	3	4	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr15:37184422A>G	uc001zjr.2	-	12	2423	c.1386T>C	c.(1384-1386)TCT>TCC	p.S462S	MEIS2_uc001zjl.2_3'UTR|MEIS2_uc010ucj.1_Silent_p.S442S|MEIS2_uc001zjm.2_3'UTR|MEIS2_uc001zjn.2_3'UTR|MEIS2_uc001zjo.2_3'UTR|MEIS2_uc001zjp.2_3'UTR|MEIS2_uc001zjs.2_Silent_p.S455S|MEIS2_uc001zju.2_3'UTR|MEIS2_uc001zjt.2_Silent_p.S455S|MEIS2_uc001zjj.2_Silent_p.S158S|MEIS2_uc001zjk.2_Silent_p.S151S	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	462					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		TGGGATCTACAGAATTTAACA	0.483													46	300					0	0	0	0	G	37184422	G	G	37184422	2	3	286	1	0	0	0	0	0	0	0	1	9521	175	7	5		5	MEIS2	15	37184422	Silent	SNP	A	TCGA-DQ-5630-01A-01D-1870-08		37184422	65346970	73	53311											
TNFAIP8L3	388121	broad.mit.edu	37	chr15	51397319	51397319	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacagtttcccctttggctCtgcctcacagagtgtggaaa	8	11	9	13	0	2	1	1	0	1	1	3	2	3	2	4	2	1	2	4	2	1	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr15:51397319C>G	uc001zyy.2	-	1	155	c.55G>C	c.(55-57)GAG>CAG	p.E19Q		NM_207381	NP_997264	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein	19											0				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		CCCTTTGGCTCTGCCTCACAG	0.512													5	119					0	0	0	0	G	51397319	G	G	51397319	3	3	286	1	0	0	0	0	1	0	0	0	16345	922	32	2	835	2	TNFAIP8L3	15	51397319	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	14212897	51397319	51134073	74	53312											
SLTM	79811	broad.mit.edu	37	chr15	59186670	59186670	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgtccatgcagctcagtgcGatgaagatgtgcaatacacc	11	9	10	11	1	1	2	1	1	0	1	2	3	2	2	2	0	5	3	2	0	3	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr15:59186670G>A	uc002afp.2	-	10	1427	c.1339C>T	c.(1339-1341)CGC>TGC	p.R447C	SLTM_uc002afn.2_Missense_Mutation_p.R16C|SLTM_uc002afo.2_Missense_Mutation_p.R429C|SLTM_uc002afq.2_Missense_Mutation_p.R16C|SLTM_uc010bgd.2_Missense_Mutation_p.R16C	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	447	RRM.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						AGCTCAGTGCGATGAAGATGT	0.413													7	105					0	0	0	0	A	59186670	A	A	59186670	3	1	286	1	0	0	0	0	1	0	0	0	14818	1058	37	1	1813	1	SLTM	15	59186670	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	7789351	59186670	43344722	75	53313											
TBC1D2B	23102	broad.mit.edu	37	chr15	78322394	78322394	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttcttttcttcctgtactaTggactcctctaggtccttag	5	18	6	12	0	3	0	0	0	3	0	6	1	6	1	3	2	1	1	3	2	4	8			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr15:78322394T>C	uc002bcy.3	-	4	802	c.802A>G	c.(802-804)ATA>GTA	p.I268V	TBC1D2B_uc010bla.2_Missense_Mutation_p.I268V	NM_144572	NP_653173	Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B isoform a	268						intracellular	protein binding|Rab GTPase activator activity			ovary(1)|large_intestine(1)|breast(1)	3						TCCTGTACTATGGACTCCTCT	0.453													9	71					0	0	0	0	C	78322394	C	C	78322394	3	2	286	1	0	0	0	0	1	0	0	0	15685	1464	51	5	2129	5	TBC1D2B	15	78322394	Missense_Mutation	SNP	T	TCGA-DQ-5630-01A-01D-1870-08	19135724	78322394	24208998	76	53314											
LONP2	83752	broad.mit.edu	37	chr16	48303932	48303932	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggttatttgacagaccgcCtggacattagggcagcccgg	8	9	14	10	2	0	2	0	1	0	1	0	3	0	3	3	4	1	2	3	4	2	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr16:48303932C>G	uc002efi.1	+	7	1077	c.988C>G	c.(988-990)CTG>GTG	p.L330V	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.L286V	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	330					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						GACAGACCGCCTGGACATTAG	0.378													8	42					0	0	0	0	G	48303932	G	G	48303932	3	3	286	1	0	0	0	0	1	0	0	0	8943	680	24	4	1014	4	LONP2	16	48303932	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08		48303932	42050821	77	53315											
ZNF276	92822	broad.mit.edu	37	chr16	89804234	89804234	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggtgcggaactatatctgtGacgaatgtggacaaaccttc	12	10	11	8	2	1	1	0	1	1	0	2	4	1	3	1	3	3	0	1	3	5	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr16:89804234G>C	uc002fos.3	+	10	1592	c.1495G>C	c.(1495-1497)GAC>CAC	p.D499H	ZNF276_uc010ciq.2_Missense_Mutation_p.D285H|ZNF276_uc002fop.2_Missense_Mutation_p.D407H|ZNF276_uc002foq.3_Missense_Mutation_p.D424H|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_Missense_Mutation_p.D285H|ZNF276_uc010cis.2_Missense_Mutation_p.D258H|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_Missense_Mutation_p.D337H|ZNF276_uc010cit.1_Missense_Mutation_p.D258H|FANCA_uc002fou.1_3'UTR|FANCA_uc010vpn.1_3'UTR	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	499	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTATATCTGTGACGAATGTGG	0.557													3	72					0	0	0	0	C	89804234	C	C	89804234	3	2	286	1	0	0	0	0	1	0	0	0	17878	1290	45	2	1533	2	ZNF276	16	89804234	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	41500302	89804234	550519	78	53316											
POLR2A	5430	broad.mit.edu	37	chr17	7416619	7416619	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcccacctctcccagctactCacccacttcccctagctact	7	9	3	22	0	2	0	1	0	1	0	4	0	3	0	6	0	4	2	6	0	3	4			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr17:7416619C>T	uc002ghf.3	+	29	5270	c.5036C>T	c.(5035-5037)TCA>TTA	p.S1679L		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1679	52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].|13.				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				cccagctactcacccacttcc	0													3	13					0	0	0	0	T	7416619	T	T	7416619	3	4	286	1	0	0	0	0	1	0	0	0	12269	838	29	2	5150	2	POLR2A	17	7416619	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08		7416619	73778591	79	53317											
TP53	7157	broad.mit.edu	37	chr17	7576868	7576886	+	Frame_Shift_Del	DEL	TTCTCCATCCAGTGGTTTC	-	-																															agtacctgaagggtgaaataTtctccatccagtggtttctt																								rs121912659		TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr17:7576868_7576886delTTCTCCATCCAGTGGTTTC	uc002gim.2	-	9	1154_1172	c.960_978delGAAACCACTGGATGGAGAA	c.(958-978)AAGAAACCACTGGATGGAGAAfs	p.K320fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.K320fs|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Frame_Shift_Del_p.K188fs|TP53_uc010cng.1_Frame_Shift_Del_p.K188fs|TP53_uc002gii.1_Frame_Shift_Del_p.K188fs|TP53_uc010cnh.1_Frame_Shift_Del_p.K320fs|TP53_uc010cni.1_Frame_Shift_Del_p.K320fs|TP53_uc002gij.2_Frame_Shift_Del_p.K320fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	320_326	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		E -> G (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.E326*(4)|p.K321fs*24(4)|p.K320N(3)|p.D324E(2)|p.K320fs*26(2)|p.K320*(2)|p.P322L(2)|p.P322R(2)|p.K321*(2)|p.S315fs*22(1)|p.L323fs*22(1)|p.K321K(1)|p.P318fs*21(1)|p.K320fs*25(1)|p.P322fs*23(1)|p.Y327fs*10(1)|p.L323V(1)|p.L323R(1)|p.?(1)|p.L323P(1)|p.D324fs*21(1)|p.G325fs*23(1)|p.L308fs*15(1)|p.L323G(1)|p.L323M(1)|p.K320K(1)|p.G325A(1)|p.D324D(1)|p.G325E(1)|p.D324S(1)|p.G325V(1)|p.K320fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGTGAAATATTCTCCATCCAGTGGTTTCTTCTTTGGCT	0.452		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7576886	-	-	7576868	7	5	286	1	0	1	0	1	0	0	0	0	16448	1490	52	0	304	0	TP53	17	7576868	Frame_Shift_Del	DEL	TTCTCCATCCAGTGGTTTC	TCGA-DQ-5630-01A-01D-1870-08	160249	7576868	73618342	80	53318											
CHD3	1107	broad.mit.edu	37	chr17	7806800	7806800	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaaatttggcactgaagagCtattcaaggatgaaaacgag	16	9	10	6	1	2	3	2	2	0	1	2	5	2	4	0	2	2	2	0	2	6	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr17:7806800C>G	uc002gje.2	+	23	3856	c.3706C>G	c.(3706-3708)CTA>GTA	p.L1236V	CHD3_uc002gjd.2_Missense_Mutation_p.L1295V|CHD3_uc002gjf.2_Missense_Mutation_p.L1236V|CHD3_uc002gjh.2_5'Flank|SCARNA21_uc002gji.1_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1236					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				CACTGAAGAGCTATTCAAGGA	0.542													7	16					0	0	0	0	G	7806800	G	G	7806800	3	3	286	1	0	0	0	0	1	0	0	0	3341	796	28	4	4077	4	CHD3	17	7806800	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	229932	7806800	73388410	81	53319											
MYH10	4628	broad.mit.edu	37	chr17	8526560	8526560	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcgagtccagttctctgcGccattgtaaatggaacgatc	9	11	9	12	3	1	0	0	0	1	0	5	3	2	1	3	1	2	2	3	1	3	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr17:8526560G>C	uc002gll.2	-	2	101	c.5C>G	c.(4-6)GCG>GGG	p.A2G	MYH10_uc002glm.2_Missense_Mutation_p.A2G|MYH10_uc010cnx.2_Missense_Mutation_p.A2G	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	2	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						AGTTCTCTGCGCCATTGTAAA	0.433													4	50					0	0	0	0	C	8526560	C	C	8526560	3	2	286	1	0	0	0	0	1	0	0	0	10083	1087	38	3	6085	3	MYH10	17	8526560	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	719760	8526560	72668650	82	53320											
DGKE	8526	broad.mit.edu	37	chr17	54923105	54923105	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taataatcctggccaactctCgtagtggaactaatatggga	13	11	9	8	1	1	0	0	0	1	0	3	2	2	2	2	3	2	1	2	3	7	5			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr17:54923105C>A	uc002iur.2	+	4	859	c.679C>A	c.(679-681)CGT>AGT	p.R227S	DGKE_uc002ius.1_Missense_Mutation_p.R227S	NM_003647	NP_003638	P52429	DGKE_HUMAN	diacylglycerol kinase epsilon	227	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)					GGCCAACTCTCGTAGTGGAAC	0.363													3	71					0.00909568	0.00952071	1	0	A	54923105	A	A	54923105	3	1	286	1	0	0	0	0	1	0	0	0	4490	884	31	3	689	3	DGKE	17	54923105	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	46396545	54923105	26272105	83	53321											
EVI5L	115704	broad.mit.edu	37	chr19	7914195	7914195	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccagggaagcgccttcatCgtgggcctgctcctcatgca	6	9	12	14	2	2	0	2	0	0	0	4	1	3	1	4	2	4	2	4	2	1	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr19:7914195C>T	uc002min.2	+	5	760	c.606C>T	c.(604-606)ATC>ATT	p.I202I	EVI5L_uc010xjz.1_Silent_p.I202I|EVI5L_uc002mio.1_5'Flank	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	202	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						GCGCCTTCATCGTGGGCCTGC	0.647													4	46					0	0	0	0	T	7914195	T	T	7914195	2	4	286	1	0	0	0	0	0	0	0	1	5314	874	31	1		1	EVI5L	19	7914195	Silent	SNP	C	TCGA-DQ-5630-01A-01D-1870-08		7914195	51214788	84	53322											
CACNA1A	773	broad.mit.edu	37	chr19	13423556	13423556	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtacatttttataaacattTcggacataaagagtcctaag	15	13	6	7	2	0	1	0	0	0	1	2	2	1	2	1	1	2	1	1	1	7	8			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr19:13423556T>C	uc010dze.2	-	12	1834	c.1598A>G	c.(1597-1599)GAA>GGA	p.E533G	CACNA1A_uc010dzc.2_Missense_Mutation_p.E58G|CACNA1A_uc002mwy.3_Missense_Mutation_p.E532G|CACNA1A_uc010xne.1_Missense_Mutation_p.E58G	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	533	Helical; Name=S2 of repeat II; (Potential).|II.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TATAAACATTTCGGACATAAA	0.458													3	48					0	0	0	0	C	13423556	C	C	13423556	3	2	286	1	0	0	0	0	1	0	0	0	2550	1783	62	5	6180	5	CACNA1A	19	13423556	Missense_Mutation	SNP	T	TCGA-DQ-5630-01A-01D-1870-08	5509361	13423556	45705427	85	53323											
KIRREL2	84063	broad.mit.edu	37	chr19	36353394	36353394	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcccctctgctccctgcaGacttgctgcccactgtgcgg	3	11	10	17	1	1	1	0	0	1	1	3	1	3	1	4	1	5	3	4	1	0	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr19:36353394G>T	uc002ocb.3	+	12	1723	c.1511_splice	c.e12-1	p.D504_splice	KIRREL2_uc002obz.3_Splice_Site_p.D504_splice|KIRREL2_uc002oca.3_Splice_Site_p.D454_splice|KIRREL2_uc002occ.3_Splice_Site_p.D451_splice|KIRREL2_uc002ocd.3_Intron	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c						cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCTCCCTGCAGACTTGCTGCC	0.617													20	136					3.62473e-10	4.14255e-10	1	0	T	36353394	T	T	36353394	5	4	286	1	0	0	0	0	0	0	1	0	8364	956	33	2	1556	2	KIRREL2	19	36353394	Splice_Site	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	22929838	36353394	22775589	86	53324											
LAIR1	3903	broad.mit.edu	37	chr19	54867583	54867583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cgaggtgtccgtctctctgtCcttctcaggaagtccattga	6	13	10	12	2	3	1	1	1	3	0	8	3	6	2	3	2	0	0	3	2	1	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr19:54867583C>T	uc002qfk.1	-	9	1007	c.697G>A	c.(697-699)GAC>AAC	p.D233N	LAIR1_uc002qfl.1_Missense_Mutation_p.D216N|LAIR1_uc002qfm.1_Missense_Mutation_p.D232N|LAIR1_uc002qfn.1_Missense_Mutation_p.D215N|LAIR1_uc010yex.1_Missense_Mutation_p.D226N|LAIR1_uc002qfo.2_Missense_Mutation_p.D215N	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like	233	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity			ovary(4)	4	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		GTCTCTCTGTCCTTCTCAGGA	0.368													20	100					0	0	0	0	T	54867583	T	T	54867583	3	4	286	1	0	0	0	0	1	0	0	0	8642	855	30	2	174	2	LAIR1	19	54867583	Missense_Mutation	SNP	C	TCGA-DQ-5630-01A-01D-1870-08	18514189	54867583	4261400	87	53325											
LILRB1	10859	broad.mit.edu	37	chr19	55143590	55143590	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctccgtgggccccgtgaGcccgagtcgcaggtggtggt	3	9	16	13	4	1	1	0	1	1	0	3	2	1	1	4	4	1	1	4	4	0	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr19:55143590G>T	uc002qgj.2	+	6	903	c.563G>T	c.(562-564)AGC>ATC	p.S188I	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.S188I|LILRB1_uc002qgk.2_Missense_Mutation_p.S188I|LILRB1_uc002qgm.2_Missense_Mutation_p.S188I|LILRB1_uc010erq.2_Missense_Mutation_p.S188I|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	188	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GGCCCCGTGAGCCCGAGTCGC	0.587										HNSCC(37;0.09)			22	159					3.5997e-14	4.19965e-14	1	0	T	55143590	T	T	55143590	3	4	286	1	0	0	0	0	1	0	0	0	8831	971	34	4	577	4	LILRB1	19	55143590	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	276007	55143590	3985393	88	53326											
KCNK15	60598	broad.mit.edu	37	chr20	43378790	43378790	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agtacggccacgccgcgccgGgtacggactccggcaaggtc	7	4	15	15	7	0	0	0	0	0	0	2	1	1	1	4	5	2	3	4	5	3	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr20:43378790G>C	uc002xmr.2	+	2	368	c.304G>C	c.(304-306)GGT>CGT	p.G102R		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	102						integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				CGCCGCGCCGGGTACGGACTC	0.682													3	18					0	0	0	0	C	43378790	C	C	43378790	3	2	286	1	0	0	0	0	1	0	0	0	8101	1232	43	4	310	4	KCNK15	20	43378790	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08		43378790	19646730	89	53327											
SLC2A10	81031	broad.mit.edu	37	chr20	45353758	45353758	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttggttatgaactggcagTcatatcaggtgccctgctgc	7	13	11	10	0	2	1	2	1	0	0	2	1	2	1	1	3	4	3	1	3	3	3			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr20:45353758T>C	uc002xsl.2	+	2	180	c.83T>C	c.(82-84)GTC>GCC	p.V28A		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	28	Helical; Name=1; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GAACTGGCAGTCATATCAGGT	0.577													9	96					0	0	0	0	C	45353758	C	C	45353758	3	2	286	1	0	0	0	0	1	0	0	0	14603	1667	58	5	89	5	SLC2A10	20	45353758	Missense_Mutation	SNP	T	TCGA-DQ-5630-01A-01D-1870-08	1974968	45353758	17671762	90	53328											
TSSK2	23617	broad.mit.edu	37	chr22	19119322	19119322	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacatcgtccaccgggaccTcaagtgcgagaaccttctcc	9	7	10	15	3	2	1	1	0	1	1	5	4	3	3	5	2	2	0	5	2	2	1			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr22:19119322T>C	uc002zow.2	+	1	1002	c.410T>C	c.(409-411)CTC>CCC	p.L137P	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	137	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					CACCGGGACCTCAAGTGCGAG	0.592													3	85					0	0	0	0	C	19119322	C	C	19119322	3	2	286	1	0	0	0	0	1	0	0	0	16736	1551	54	5	412	5	TSSK2	22	19119322	Missense_Mutation	SNP	T	TCGA-DQ-5630-01A-01D-1870-08		19119322	32185244	91	53329											
XPNPEP3	63929	broad.mit.edu	37	chr22	41265050	41265050	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actcccttcagcctgtcccaGaaaggaggattccaaaccga	12	7	8	14	1	1	1	1	0	0	1	4	4	4	3	5	2	2	0	5	2	2	2			TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chr22:41265050G>C	uc003azh.2	+	2	204	c.112G>C	c.(112-114)GAA>CAA	p.E38Q	XPNPEP3_uc011aox.1_Missense_Mutation_p.E38Q|XPNPEP3_uc003azi.2_5'UTR|XPNPEP3_uc011aoy.1_RNA|XPNPEP3_uc010gyh.1_RNA	NM_022098	NP_071381	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3,	38					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity				0						GCCTGTCCCAGAAAGGAGGAT	0.458													7	134					0	0	0	0	C	41265050	C	C	41265050	3	2	286	1	0	0	0	0	1	0	0	0	17512	943	33	2	118	2	XPNPEP3	22	41265050	Missense_Mutation	SNP	G	TCGA-DQ-5630-01A-01D-1870-08	22145728	41265050	10039516	92	53330											
GPM6B	2824	broad.mit.edu	37	chrX	13801551	13801553	+	In_Frame_Del	DEL	GTG	-	-																															gcagttctttcactgcacttGtggtgtaaaagccttctgcc																										TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chrX:13801551_13801553delGTG	uc004cvz.2	-	3	627_629	c.336_338delCAC	c.(334-339)ACCACA>ACA	p.112_113TT>T	GPM6B_uc004cvx.2_In_Frame_Del_p.93_94TT>T|GPM6B_uc011min.1_In_Frame_Del_p.26_27TT>T|GPM6B_uc004cwa.2_In_Frame_Del_p.93_94TT>T|GPM6B_uc004cvw.2_In_Frame_Del_p.152_153TT>T|GPM6B_uc011mim.1_In_Frame_Del_p.126_127TT>T|GPM6B_uc004cvy.2_In_Frame_Del_p.152_153TT>T	NM_005278	NP_005269	Q13491	GPM6B_HUMAN	glycoprotein M6B isoform 3	112_113					cell differentiation|nervous system development	integral to membrane					0						CACTGCACTTGTGGTGTAAAAGC	0.424													---	---	---								-	13801553	-	-	13801551	7	5	286	1	0	1	0	1	0	0	0	0	6654	1377	48	0	633	0	GPM6B	23	13801551	In_Frame_Del	DEL	GTG	TCGA-DQ-5630-01A-01D-1870-08		13801551	141469009	93	53331											
ALG13	79868	broad.mit.edu	37	chrX	110987997	110987999	+	In_Frame_Del	DEL	CCT	-	-																															caccaccaccaccaccaccaCctcctcctcctcctcctcct																								rs13440710		TCGA-DQ-5630-01A-01D-1870-08	TCGA-DQ-5630-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	5aa7ff44-d4ff-4163-81db-9f09bec8d5b0	febb95f7-3b98-42ae-896c-3fa1f04ef94d	g.chrX:110987997_110987999delCCT	uc011msy.1	+	24	2831_2833	c.2797_2799delCCT	c.(2797-2799)CCTdel	p.P945del	ALG13_uc011msx.1_Intron|ALG13_uc011msz.1_In_Frame_Del_p.P867del|ALG13_uc011mta.1_Intron|ALG13_uc011mtb.1_Intron			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	945	Pro-rich.				dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						accaccaccacctcctcctcctc	0.197													---	---	---								-	110987999	-	-	110987997	7	5	286	1	0	1	0	1	0	0	0	0	515	507	18	0	3033	0	ALG13	23	110987997	In_Frame_Del	DEL	CCT	TCGA-DQ-5630-01A-01D-1870-08	97186446	110987997	44282563	94	53332											
CAMTA1	23261	broad.mit.edu	37	chr1	7724491	7724491	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcaaacccctccccgtcgaGcagaacacccacagcagcct	12	3	7	19	2	0	1	0	0	0	1	2	2	1	1	6	0	6	3	6	0	2	0			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:7724491G>A	uc001aoi.2	+	9	2091	c.1884G>A	c.(1882-1884)GAG>GAA	p.E628E		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	628					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCCCCGTCGAGCAGAACACCC	0.652													4	219					0	0	0	0	A	7724491	A	A	7724491	2	1	287	1	0	0	0	0	0	0	0	1	2625	962	34	4		4	CAMTA1	1	7724491	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08		7724491	241526130	1	53333											
NBPF1	55672	broad.mit.edu	37	chr1	16918363	16918363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtatttcttctgtcggttggCcaggaagccggccagttgag	6	12	14	9	2	2	1	0	1	2	0	3	2	2	2	3	4	1	3	3	4	2	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:16918363C>T	uc009vos.1	-	7	1042	c.154G>A	c.(154-156)GCC>ACC	p.A52T	NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	52						cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGTCGGTTGGCCAGGAAGCCG	0.448													7	782					0	0	0	0	T	16918363	T	T	16918363	3	4	287	1	0	0	0	0	1	0	0	0	10245	739	26	4	3362	4	NBPF1	1	16918363	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	9193872	16918363	232332258	2	53334											
COL11A1	1301	broad.mit.edu	37	chr1	103444279	103444279	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgtactctttcacctggaggGccaggagggccatcgccacc	7	7	12	15	2	2	0	1	0	1	0	3	2	2	2	5	4	1	1	5	4	1	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:103444279G>A	uc001dul.2	-	35	3057	c.2739C>T	c.(2737-2739)GGC>GGT	p.G913G	COL11A1_uc001duk.2_Silent_p.G109G|COL11A1_uc001dum.2_Silent_p.G925G|COL11A1_uc001dun.2_Silent_p.G874G|COL11A1_uc009weh.2_Silent_p.G797G	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	913	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CACCTGGAGGGCCAGGAGGGC	0.383													24	158					0	0	0	0	A	103444279	A	A	103444279	2	1	287	1	0	0	0	0	0	0	0	1	3682	1190	42	4		4	COL11A1	1	103444279	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	86525916	103444279	145806342	3	53335											
NOTCH2	4853	broad.mit.edu	37	chr1	120539889	120539893	+	Frame_Shift_Del	DEL	GTGGT	-	-																															aggagaactggttggccacaGtggtacaggtacttccattt																										TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:120539889_120539893delGTGGT	uc001eik.2	-	4	734_738	c.478_482delACCAC	c.(478-483)ACCACTfs	p.T160fs	NOTCH2_uc001eil.2_Frame_Shift_Del_p.T160fs|NOTCH2_uc001eim.3_Frame_Shift_Del_p.T77fs	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	160_161	Extracellular (Potential).|EGF-like 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTTGGCCACAGTGGTACAGGTACTT	0.502			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				---	---	---								-	120539893	-	-	120539889	7	5	287	1	0	1	0	1	0	0	0	0	10602	1029	36	0	7057	0	NOTCH2	1	120539889	Frame_Shift_Del	DEL	GTGGT	TCGA-DQ-5631-01A-01D-1870-08	17095610	120539889	128710732	4	53336											
RPTN	126638	broad.mit.edu	37	chr1	152128025	152128028	+	Frame_Shift_Del	DEL	TGTC	-	-																															catagtggaaactctggcctTgtctgtctgtctgaccatag																										TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:152128025_152128028delTGTC	uc001ezs.1	-	3	1612_1615	c.1547_1550delGACA	c.(1546-1551)AGACAAfs	p.R516fs		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	516_517	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						ACTCTGGCCTTGTCTGTCTGTCTG	0.5													---	---	---								-	152128028	-	-	152128025	7	5	287	1	0	1	0	1	0	0	0	0	13729	1812	63	0	808	0	RPTN	1	152128025	Frame_Shift_Del	DEL	TGTC	TCGA-DQ-5631-01A-01D-1870-08	31588136	152128025	97122596	5	53337											
HRNR	388697	broad.mit.edu	37	chr1	152190959	152190959	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gagactctcggtgacctaagCcagaagagtgaccggagcca	12	5	13	11	2	1	5	0	2	1	3	2	7	1	6	4	2	2	0	4	2	2	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:152190959C>G	uc001ezt.1	-	3	3222	c.3146G>C	c.(3145-3147)GGC>GCC	p.G1049A		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1049	12.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGACCTAAGCCAGAAGAGTG	0.562													50	223					0	0	0	0	G	152190959	G	G	152190959	3	3	287	1	0	0	0	0	1	0	0	0	7398	739	26	4	5410	4	HRNR	1	152190959	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	62934	152190959	97059662	6	53338											
FCGR3B	2215	broad.mit.edu	37	chr1	161596179	161596179	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aacacccaccgaggggcctgGagcaacagccagcctgaaag	13	2	12	14	1	0	1	0	1	0	0	0	3	0	2	5	3	5	1	5	3	3	0			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:161596179G>C	uc009wul.2	-	4	607	c.333C>G	c.(331-333)CTC>CTG	p.L111L		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	111					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GAGGGGCCTGGAGCAACAGCC	0.562													4	27					0	0	0	0	C	161596179	C	C	161596179	2	2	287	1	0	0	0	0	0	0	0	1	5817	1161	41	2		2	FCGR3B	1	161596179	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	9405220	161596179	87654442	7	53339											
GLRX2	51022	broad.mit.edu	37	chr1	193070317	193070317	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaaattctccaaagatgatGatgtattgctctccatccta	12	14	5	10	0	2	3	0	2	2	1	5	3	3	3	3	0	1	2	3	0	5	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:193070317G>A	uc001gsz.1	-	2	181	c.137C>T	c.(136-138)TCA>TTA	p.S46L	GLRX2_uc001gta.1_Missense_Mutation_p.S47L	NM_197962	NP_932066	Q9NS18	GLRX2_HUMAN	glutaredoxin 2 isoform 2	46					apoptosis|cell differentiation|cell redox homeostasis|DNA protection|electron transport chain|glutathione metabolic process|protein thiol-disulfide exchange|regulation of signal transduction|regulation of transcription, DNA-dependent|response to hydrogen peroxide|response to organic substance|response to redox state|response to temperature stimulus|transport	mitochondrion|nucleus	2 iron, 2 sulfur cluster binding|arsenate reductase (glutaredoxin) activity|electron carrier activity|glutathione disulfide oxidoreductase activity|metal ion binding|protein disulfide oxidoreductase activity				0					Glutathione(DB00143)	CAAAGATGATGATGTATTGCT	0.343													15	47					0	0	0	0	A	193070317	A	A	193070317	3	1	287	1	0	0	0	0	1	0	0	0	6497	1294	45	2	369	2	GLRX2	1	193070317	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	31474138	193070317	56180304	8	53340											
WNT9A	7483	broad.mit.edu	37	chr1	228111988	228111988	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcctcacggttctccaggtCgggtgcctcatcgcaggtac	5	9	13	14	3	3	0	2	0	1	0	6	0	3	0	3	5	2	3	3	5	1	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:228111988C>T	uc001hri.2	-	3	554	c.466G>A	c.(466-468)GAC>AAC	p.D156N		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	156					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				TTCTCCAGGTCGGGTGCCTCA	0.632													29	89					0	0	0	0	T	228111988	T	T	228111988	3	4	287	1	0	0	0	0	1	0	0	0	17466	884	31	1	639	1	WNT9A	1	228111988	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	35041671	228111988	21138633	9	53341											
RYR2	6262	broad.mit.edu	37	chr1	237670089	237670089	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actctgggttatgaataaaaTtgagcttggctggcagtatg	11	13	12	5	0	1	2	0	2	1	0	1	2	1	2	0	3	1	5	0	3	5	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:237670089T>C	uc001hyl.1	+	23	2813	c.2693T>C	c.(2692-2694)ATT>ACT	p.I898T		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	898	Cytoplasmic (By similarity).|1.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATGAATAAAATTGAGCTTGGC	0.333													7	34					0	0	0	0	C	237670089	C	C	237670089	3	2	287	1	0	0	0	0	1	0	0	0	13834	1493	52	5	2783	5	RYR2	1	237670089	Missense_Mutation	SNP	T	TCGA-DQ-5631-01A-01D-1870-08	9558101	237670089	11580532	10	53342											
ZNF496	84838	broad.mit.edu	37	chr1	247473644	247473644	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acttggaggcattgagacccCgtaatcctccccaatgatga	11	9	9	12	1	0	3	0	3	0	1	2	5	2	4	5	2	0	2	5	2	2	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr1:247473644C>T	uc001ico.2	-	6	1231	c.766G>A	c.(766-768)GGG>AGG	p.G256R	ZNF496_uc009xgv.2_Missense_Mutation_p.G292R|ZNF496_uc001icp.2_Missense_Mutation_p.G256R|ZNF496_uc001icq.1_Missense_Mutation_p.G31R|ZNF496_uc010pyv.1_Missense_Mutation_p.G256R	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	256	KRAB.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			ATTGAGACCCCGTAATCCTCC	0.493													15	49					0	0	0	0	T	247473644	T	T	247473644	3	4	287	1	0	0	0	0	1	0	0	0	18012	652	23	1	1013	1	ZNF496	1	247473644	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	9803555	247473644	1776977	11	53343											
TTC27	55622	broad.mit.edu	37	chr2	33007733	33007733	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgtcaacttcctatatccGattaaaacaaaagtaagtac	16	13	4	8	1	1	0	1	0	0	0	3	1	3	0	2	0	3	2	2	0	9	7			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr2:33007733G>A	uc002rom.2	+	15	2051	c.1820G>A	c.(1819-1821)CGA>CAA	p.R607Q	TTC27_uc010ymx.1_Missense_Mutation_p.R557Q|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	607	TPR 5.|HAT 2.						protein binding			central_nervous_system(1)	1						TCCTATATCCGATTAAAACAA	0.294													14	43					0	0	0	0	A	33007733	A	A	33007733	3	1	287	1	0	0	0	0	1	0	0	0	16763	1058	37	1	1878	1	TTC27	2	33007733	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08		33007733	210191640	12	53344											
THADA	63892	broad.mit.edu	37	chr2	43804258	43804258	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtccaacatggcaagtgTcccctgacagaggaataaga	14	6	10	11	0	0	3	0	1	0	2	2	4	2	4	4	2	1	1	4	2	4	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr2:43804258T>G	uc002rsw.3	-	10	1292	c.940A>C	c.(940-942)ACA>CCA	p.T314P	THADA_uc002rsx.3_Missense_Mutation_p.T314P|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_5'Flank|THADA_uc002rsz.2_Missense_Mutation_p.T24P|THADA_uc002rta.2_Missense_Mutation_p.T24P|THADA_uc002rtb.1_Missense_Mutation_p.T314P|THADA_uc002rtc.3_Missense_Mutation_p.T314P|THADA_uc002rtd.2_Missense_Mutation_p.T314P	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	314							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				ATGGCAAGTGTCCCCTGACAG	0.542											OREG0014580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	13					0	0	0	0	G	43804258	G	G	43804258	3	3	287	1	0	0	0	0	1	0	0	0	15906	1667	58	5	5037	5	THADA	2	43804258	Missense_Mutation	SNP	T	TCGA-DQ-5631-01A-01D-1870-08	10796525	43804258	199395115	13	53345											
CCDC138	165055	broad.mit.edu	37	chr2	109408186	109408186	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaacaggaaacagaagaaGagttaattgaaaatgattat	22	8	9	2	0	0	6	0	2	0	4	0	7	0	7	0	1	2	1	0	1	8	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr2:109408186G>A	uc002ten.1	+	4	382	c.322G>A	c.(322-324)GAG>AAG	p.E108K	CCDC138_uc002teo.1_Missense_Mutation_p.E108K|CCDC138_uc002tep.1_5'UTR|CCDC138_uc010fjm.1_5'UTR	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	108											0						AACAGAAGAAGAGTTAATTGA	0.269													36	139					0	0	0	0	A	109408186	A	A	109408186	3	1	287	1	0	0	0	0	1	0	0	0	2784	943	33	2	336	2	CCDC138	2	109408186	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	65603928	109408186	133791187	14	53346											
GLI2	2736	broad.mit.edu	37	chr2	121746950	121746950	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgaggtgagctccggcaccGtagacgccctggccagccag	8	5	14	14	3	0	3	0	2	0	1	1	3	1	3	5	3	2	3	5	3	1	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr2:121746950G>A	uc010flp.2	+	13	3490	c.3460G>A	c.(3460-3462)GTA>ATA	p.V1154I	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Missense_Mutation_p.V826I|GLI2_uc002tmu.3_Missense_Mutation_p.V809I	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1154					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CTCCGGCACCGTAGACGCCCT	0.622													4	30					0	0	0	0	A	121746950	A	A	121746950	3	1	287	1	0	0	0	0	1	0	0	0	6475	1145	40	1	3510	1	GLI2	2	121746950	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	12338764	121746950	121452423	15	53347											
NEB	4703	broad.mit.edu	37	chr2	152543963	152543963	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttggctgtcttcaaggaGtgcagcatctttggatcgtc	6	16	11	8	1	3	0	1	0	2	0	5	2	3	2	0	3	2	3	0	3	1	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr2:152543963G>C	uc010fnx.2	-	27	2798	c.2607C>G	c.(2605-2607)CAC>CAG	p.H869Q		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	869	Nebulin 20.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCTTCAAGGAGTGCAGCATCT	0.438													43	155					0	0	0	0	C	152543963	C	C	152543963	3	2	287	1	0	0	0	0	1	0	0	0	10356	1020	36	4	23703	4	NEB	2	152543963	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	30797013	152543963	90655410	16	53348											
CERKL	375298	broad.mit.edu	37	chr2	182423402	182423402	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcaaagcatgggctacttcGctagcagatccatctccacc	11	8	8	14	1	1	1	0	0	1	1	4	1	2	1	3	1	4	5	3	1	3	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr2:182423402G>A	uc002unx.2	-	6	890	c.789C>T	c.(787-789)AGC>AGT	p.S263S	CERKL_uc002uny.2_Silent_p.S237S|CERKL_uc010zfm.1_Silent_p.S219S|CERKL_uc002unz.2_5'UTR|CERKL_uc002uoa.2_Intron|CERKL_uc002uob.2_5'UTR|CERKL_uc002uoc.2_Intron|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_Silent_p.S32S|CERKL_uc002uoe.2_Silent_p.S237S	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	263	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			GGGCTACTTCGCTAGCAGATC	0.433													15	28					0	0	0	0	A	182423402	A	A	182423402	2	1	287	1	0	0	0	0	0	0	0	1	3283	1078	38	1		1	CERKL	2	182423402	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	29879439	182423402	60775971	17	53349											
DNAJC10	54431	broad.mit.edu	37	chr2	183616459	183616459	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgttaccacgcttggacctCaaaattttcctgccaatgac	11	12	6	12	1	1	1	1	1	0	0	2	2	2	2	4	1	2	2	4	1	4	4	rs75109237		TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr2:183616459C>T	uc002uow.1	+	15	1796	c.1381C>T	c.(1381-1383)CAA>TAA	p.Q461*	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Nonsense_Mutation_p.Q415*|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	461	Thioredoxin 2.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GCTTGGACCTCAAAATTTTCC	0.368													40	165					0	0	0	0	T	183616459	T	T	183616459	4	4	287	1	0	0	0	0	0	1	0	0	4651	827	29	2	1431	2	DNAJC10	2	183616459	Nonsense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	1193057	183616459	59582914	18	53350											
IQCA1	79781	broad.mit.edu	37	chr2	237374156	237374156	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctcatgttcacctgcattcGatgaaccaatgccggatctg	9	11	9	12	2	3	1	2	1	1	0	4	3	3	2	3	1	3	3	3	1	2	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr2:237374156G>A	uc002vvz.1	-	6	1100	c.918C>T	c.(916-918)ATC>ATT	p.I306I	IQCA1_uc002vwb.2_Silent_p.I313I|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Silent_p.I306I	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	306							ATP binding			ovary(1)	1						ACCTGCATTCGATGAACCAAT	0.423													11	30					0	0	0	0	A	237374156	A	A	237374156	2	1	287	1	0	0	0	0	0	0	0	1	7841	1048	37	1		1	IQCA1	2	237374156	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	53757697	237374156	5825217	19	53351											
SLC25A20	788	broad.mit.edu	37	chr3	48921543	48921543	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggggcagccattccccgataTagccccgtgatgccctgcaa	8	7	11	15	2	0	1	0	1	0	0	1	2	1	1	6	2	4	2	6	2	3	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr3:48921543T>C	uc003cva.3	-	3	388	c.213A>G	c.(211-213)CTA>CTG	p.L71L	SLC25A20_uc011bbw.1_Silent_p.L21L|SLC25A20_uc010hkj.2_Intron	NM_000387	NP_000378	O43772	MCAT_HUMAN	carnitine/acylcarnitine translocase	71	Solcar 1.|Mitochondrial matrix (Potential).				carnitine shuttle|cellular lipid metabolic process|regulation of fatty acid oxidation	integral to membrane|mitochondrial inner membrane	acyl carnitine transporter activity				0				BRCA - Breast invasive adenocarcinoma(193;0.000168)|Kidney(197;0.00231)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	L-Carnitine(DB00583)	TTCCCCGATATAGCCCCGTGA	0.498													30	54					0	0	0	0	C	48921543	C	C	48921543	2	2	287	1	0	0	0	0	0	0	0	1	14547	1393	49	5		5	SLC25A20	3	48921543	Silent	SNP	T	TCGA-DQ-5631-01A-01D-1870-08		48921543	149100887	20	53352											
JAKMIP1	152789	broad.mit.edu	37	chr4	6107634	6107634	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaaatgtaggccgtgtgccGtcgctgctcctgctcgcgct	4	10	13	14	6	0	0	0	0	0	0	3	1	1	0	3	1	3	5	3	1	2	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr4:6107634G>A	uc003giu.3	-	3	466	c.190C>T	c.(190-192)CGG>TGG	p.R64W	JAKMIP1_uc010idb.1_Missense_Mutation_p.R64W|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Missense_Mutation_p.R64W|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Missense_Mutation_p.R64W|JAKMIP1_uc010ide.2_Missense_Mutation_p.R64W	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	64	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						GCCGTGTGCCGTCGCTGCTCC	0.622													15	45					0	0	0	0	A	6107634	A	A	6107634	3	1	287	1	0	0	0	0	1	0	0	0	7979	1144	40	1	2456	1	JAKMIP1	4	6107634	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08		6107634	185046642	21	53353											
RBM47	54502	broad.mit.edu	37	chr4	40440734	40440734	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgggccctcccagccgggCggtgggccgccgtacttgcg	2	6	17	16	6	0	0	0	0	0	0	1	0	1	0	5	4	4	1	5	4	1	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr4:40440734C>T	uc003gvc.2	-	4	887	c.177G>A	c.(175-177)CCG>CCA	p.P59P	RBM47_uc003gvd.2_Silent_p.P59P|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Silent_p.P21P|RBM47_uc003gvg.1_Silent_p.P59P	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	59						nucleus	nucleotide binding|RNA binding			breast(3)	3						CCCAGCCGGGCGGTGGGCCGC	0.711													3	11					0	0	0	0	T	40440734	T	T	40440734	2	4	287	1	0	0	0	0	0	0	0	1	13206	755	27	1		1	RBM47	4	40440734	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	34333100	40440734	150713542	22	53354											
GABRG1	2565	broad.mit.edu	37	chr4	46099293	46099293	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgtgatatctccttcatGaatttttggggccaagaccc	8	15	9	9	0	2	3	1	2	1	1	3	3	2	3	3	2	0	0	3	2	3	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr4:46099293G>T	uc003gxb.2	-	2	330	c.178C>A	c.(178-180)CAT>AAT	p.H60N		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	60	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TCTCCTTCATGAATTTTTGGG	0.368													16	133					3.52763e-06	3.86095e-06	1	0	T	46099293	T	T	46099293	3	4	287	1	0	0	0	0	1	0	0	0	6205	1290	45	2	1251	2	GABRG1	4	46099293	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	5658559	46099293	145054983	23	53355											
ADAMTS3	9508	broad.mit.edu	37	chr4	73148992	73148992	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcagccatttgtgaagctGaactgaggtggaccctcttg	9	10	12	10	0	1	3	0	3	1	0	1	4	1	4	2	2	4	2	2	2	2	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr4:73148992G>A	uc003hgk.1	-	22	3516	c.3479C>T	c.(3478-3480)TCA>TTA	p.S1160L		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1160					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTGTGAAGCTGAACTGAGGTG	0.498													8	145					0	0	0	0	A	73148992	A	A	73148992	3	1	287	1	0	0	0	0	1	0	0	0	267	1294	45	2	142	2	ADAMTS3	4	73148992	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	27049699	73148992	118005284	24	53356											
FGA	2243	broad.mit.edu	37	chr4	155507529	155507529	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtactaccaggtctagggCtcccagggttttggtttcca	6	12	12	11	1	1	0	0	0	1	0	3	0	3	0	3	5	2	4	3	5	3	6			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr4:155507529C>A	uc003iod.1	-	5	1110	c.1052G>T	c.(1051-1053)AGC>ATC	p.S351I	FGA_uc003ioe.1_Missense_Mutation_p.S351I|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	351	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AGGTCTAGGGCTCCCAGGGTT	0.557													35	59					1.836e-18	2.1267e-18	1	0	A	155507529	A	A	155507529	3	1	287	1	0	0	0	0	1	0	0	0	5862	797	28	4	1600	4	FGA	4	155507529	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	82358537	155507529	35646747	25	53357											
FAT1	2195	broad.mit.edu	37	chr4	187542861	187542861	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atactccgcttggttacttcGatctaattctttggcagttt	7	18	7	9	2	2	0	0	0	2	0	4	1	3	0	1	2	2	4	1	2	3	8			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr4:187542861G>A	uc003izf.2	-	10	5067	c.4879C>T	c.(4879-4881)CGA>TGA	p.R1627*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1627	Extracellular (Potential).|Cadherin 14.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGGTTACTTCGATCTAATTCT	0.368										HNSCC(5;0.00058)			10	18					0	0	0	0	A	187542861	A	A	187542861	4	1	287	1	0	0	0	0	0	1	0	0	5721	1066	37	1	8959	1	FAT1	4	187542861	Nonsense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	32035332	187542861	3611415	26	53358											
DAB2	1601	broad.mit.edu	37	chr5	39381673	39381673	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcctgaaggttctgagaCgggaggagcaaagatgtctg	10	8	16	7	1	2	3	0	2	2	2	2	6	2	5	1	4	1	2	1	4	2	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr5:39381673C>T	uc003jlx.2	-	11	1918	c.1387G>A	c.(1387-1389)GTC>ATC	p.V463I	DAB2_uc003jlw.2_Missense_Mutation_p.V442I	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	463					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			GGTTCTGAGACGGGAGGAGCA	0.542													46	132					0	0	0	0	T	39381673	T	T	39381673	3	4	287	1	0	0	0	0	1	0	0	0	4235	536	19	1	941	1	DAB2	5	39381673	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08		39381673	141533587	27	53359											
PDE8B	8622	broad.mit.edu	37	chr5	76645253	76645253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccattaacagtatgtcaacCcagccttcgaaaggatgatg	13	9	8	11	1	1	1	1	1	0	0	2	3	1	2	3	1	3	1	3	1	4	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr5:76645253C>T	uc003kfa.2	+	8	931	c.886C>T	c.(886-888)CCA>TCA	p.P296S	PDE8B_uc003kfb.2_Missense_Mutation_p.P276S|PDE8B_uc003kfc.2_Missense_Mutation_p.P296S|PDE8B_uc003kfd.2_Intron|PDE8B_uc003kfe.2_Intron	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	296	PAS.				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GTATGTCAACCCAGCCTTCGA	0.507													37	23					0	0	0	0	T	76645253	T	T	76645253	3	4	287	1	0	0	0	0	1	0	0	0	11708	623	22	4	916	4	PDE8B	5	76645253	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	37263580	76645253	104270007	28	53360											
PCDHGA4	56111	broad.mit.edu	37	chr5	140736077	140736077	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccactgtctacagaaactcAtatttcactgcaagtgatgg	12	12	7	10	0	3	2	2	1	1	1	4	2	4	2	1	1	3	1	1	1	4	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr5:140736077A>T	uc003ljq.1	+	1	1310	c.1310A>T	c.(1309-1311)CAT>CTT	p.H437L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.H437L	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	437	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGAAACTCATATTTCACTG	0.468													21	33					0	0	0	0	T	140736077	T	T	140736077	3	4	287	1	0	0	0	0	1	0	0	0	11610	217	8	5	1312	5	PCDHGA4	5	140736077	Missense_Mutation	SNP	A	TCGA-DQ-5631-01A-01D-1870-08	64090824	140736077	40179183	29	53361											
FOXI1	2299	broad.mit.edu	37	chr5	169535116	169535116	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcgacaatggaaatttccGcaggaaaaggaagagaaaat	18	7	11	5	2	0	1	0	0	0	1	2	6	1	4	1	3	0	2	1	3	7	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr5:169535116G>A	uc003mai.3	+	2	683	c.638G>A	c.(637-639)CGC>CAC	p.R213H	FOXI1_uc003maj.3_Intron	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	213	Fork-head.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGAAATTTCCGCAGGAAAAGG	0.493									Pendred_syndrome				19	34					0	0	0	0	A	169535116	A	A	169535116	3	1	287	1	0	0	0	0	1	0	0	0	6043	1087	38	1	644	1	FOXI1	5	169535116	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	28799039	169535116	11380144	30	53362											
HIST1H2BJ	8970	broad.mit.edu	37	chr6	27100329	27100329	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgcgctcgaaaatgtcgttCacaaacgaattcatgatgcc	13	10	8	10	4	2	1	2	1	0	0	4	3	2	1	1	0	3	2	1	0	4	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr6:27100329C>T	uc003niv.2	-	1	247	c.201G>A	c.(199-201)GTG>GTA	p.V67V	HIST1H2BJ_uc003niu.1_RNA|HIST1H2AG_uc003niw.2_5'Flank	NM_021058	NP_066402	P06899	H2B1J_HUMAN	histone cluster 1, H2bj	67					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						AAATGTCGTTCACAAACGAAT	0.562													55	161					0	0	0	0	T	27100329	T	T	27100329	2	4	287	1	0	0	0	0	0	0	0	1	7188	813	29	2		2	HIST1H2BJ	6	27100329	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08		27100329	144014738	31	53363											
PRRT1	80863	broad.mit.edu	37	chr6	32119728	32119728	+	5'Flank	DEL	C	-	-																															tggagagatgaaggcagcggCggggggggggggcggggggg																										TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr6:32119728delC	uc003nzt.2	-						PRRT1_uc003nzs.2_5'Flank|PRRT1_uc003nzu.2_Intron|PPT2_uc003nzw.2_5'Flank|PPT2_uc003nzx.2_5'Flank|PPT2_uc011dpi.1_5'Flank|PPT2_uc003nzy.1_5'Flank|PPT2_uc003nzz.2_5'Flank|PPT2_uc003oaa.2_5'Flank|PPT2_uc010jtu.1_5'Flank	NM_030651	NP_085154	Q99946	PRRT1_HUMAN	NG5 protein						response to biotic stimulus	integral to membrane				breast(1)	1						AAGGCAGCGGCgggggggggg	0.507													---	---	---								-	32119728	-	-	32119728	6	5	287	0	1	1	0	1	0	0	0	0	12671	783	27	0		0	PRRT1	6	32119728	5'Flank	DEL	C	TCGA-DQ-5631-01A-01D-1870-08	5019399	32119728	138995339	32	53364											
EFHC1	114327	broad.mit.edu	37	chr6	52334164	52334164	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ataacggttttggactagtgGaagattctgctcagaattgt	11	14	11	5	1	2	2	1	0	1	2	2	4	2	4	0	3	2	2	0	3	4	6			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr6:52334164G>A	uc003pap.3	+	7	1386	c.1171G>A	c.(1171-1173)GAA>AAA	p.E391K	EFHC1_uc011dwv.1_Missense_Mutation_p.E300K|EFHC1_uc011dww.1_Missense_Mutation_p.E372K	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	391						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					TGGACTAGTGGAAGATTCTGC	0.378													25	90					0	0	0	0	A	52334164	A	A	52334164	3	1	287	1	0	0	0	0	1	0	0	0	4968	1175	41	2	1207	2	EFHC1	6	52334164	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	20214436	52334164	118780903	33	53365											
DST	667	broad.mit.edu	37	chr6	56334934	56334934	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gataatgagtacctcatcttCgattttgtcggcatctgtga	9	15	9	8	2	3	2	1	2	2	0	5	4	3	2	1	1	1	2	1	1	2	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr6:56334934C>T	uc003pdf.2	-	90	16139	c.16111G>A	c.(16111-16113)GAA>AAA	p.E5371K	DST_uc003pcz.3_Missense_Mutation_p.E5193K|DST_uc011dxj.1_Missense_Mutation_p.E5222K|DST_uc011dxk.1_Missense_Mutation_p.E5233K|DST_uc003pcy.3_Missense_Mutation_p.E4867K|DST_uc003pcw.3_5'Flank|DST_uc003pcx.3_5'Flank	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7279	GAR.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACCTCATCTTCGATTTTGTCG	0.378													9	35					0	0	0	0	T	56334934	T	T	56334934	3	4	287	1	0	0	0	0	1	0	0	0	4805	893	31	1	948	1	DST	6	56334934	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	4000770	56334934	114780133	34	53366											
STX1A	6804	broad.mit.edu	37	chr7	73117214	73117214	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccatgtccatgaacatgtcGtgtagctcacggatgctgtt	8	12	11	10	2	1	1	1	1	0	0	3	2	2	2	2	1	3	4	2	1	2	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr7:73117214G>A	uc003tyx.2	-	8	666	c.639C>T	c.(637-639)CAC>CAT	p.H213H	WBSCR22_uc003tyw.1_Intron|STX1A_uc003tyy.2_Silent_p.H213H|STX1A_uc010lbj.1_Silent_p.H213H	NM_004603	NP_004594	Q16623	STX1A_HUMAN	syntaxin 1A isoform 1	213	Cytoplasmic (Potential).|t-SNARE coiled-coil homology.				energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				TGAACATGTCGTGTAGCTCAC	0.592													23	48					0	0	0	0	A	73117214	A	A	73117214	2	1	287	1	0	0	0	0	0	0	0	1	15409	1136	40	1		1	STX1A	7	73117214	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08		73117214	86021449	35	53367											
MUC17	140453	broad.mit.edu	37	chr7	100684621	100684621	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaacaactcctgctgacacCagcacacctgtgaccactta	12	8	5	16	0	1	2	1	2	0	0	2	2	2	2	4	0	4	2	4	0	3	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr7:100684621C>A	uc003uxp.1	+	3	9977	c.9924C>A	c.(9922-9924)ACC>ACA	p.T3308T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3308	Extracellular (Potential).|Ser-rich.|53.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGCTGACACCAGCACACCTG	0.498													164	408					1.33315e-76	1.57041e-76	1	0	A	100684621	A	A	100684621	2	1	287	1	0	0	0	0	0	0	0	1	10027	581	21	4		4	MUC17	7	100684621	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	27567407	100684621	58454042	36	53368											
MKRN1	23608	broad.mit.edu	37	chr7	140159671	140159671	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gacttgaggaagcagcaaggGatgactttgtagttagctct	11	11	13	6	0	1	2	0	2	1	0	1	5	1	4	0	2	3	5	0	2	4	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr7:140159671G>C	uc003vvt.2	-	3	605	c.380C>G	c.(379-381)TCC>TGC	p.S127C	MKRN1_uc003vvs.2_Missense_Mutation_p.S63C|MKRN1_uc011krd.1_Intron|MKRN1_uc003vvv.3_Missense_Mutation_p.S127C|MKRN1_uc003vvu.3_Missense_Mutation_p.S63C	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	127							ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					AGCAGCAAGGGATGACTTTGT	0.378													28	71					0	0	0	0	C	140159671	C	C	140159671	3	2	287	1	0	0	0	0	1	0	0	0	9659	1174	41	2	1096	2	MKRN1	7	140159671	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	39475050	140159671	18978992	37	53369											
ASB10	136371	broad.mit.edu	37	chr7	150878272	150878272	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctggtccgcagcatcagcGtctgctccagctgaaagcag	8	8	11	14	2	2	1	1	1	1	0	5	1	5	1	3	1	5	5	3	1	1	0			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr7:150878272G>A	uc003wjm.1	-	3	1119	c.993C>T	c.(991-993)GAC>GAT	p.D331D	ASB10_uc003wjl.1_Silent_p.D331D|ASB10_uc003wjn.1_Silent_p.D271D	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	286	ANK 5.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGCATCAGCGTCTGCTCCAG	0.672													5	23					0	0	0	0	A	150878272	A	A	150878272	2	1	287	1	0	0	0	0	0	0	0	1	1016	1136	40	1		1	ASB10	7	150878272	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	10718601	150878272	8260391	38	53370											
CSMD1	64478	broad.mit.edu	37	chr8	2876011	2876011	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaatttacccagacatcgagTttcgctgccgctccagagcc	9	9	9	14	3	0	2	0	0	0	2	3	4	1	2	4	0	3	3	4	0	2	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr8:2876011T>A	uc011kwk.1	-	52	8410	c.8020A>T	c.(8020-8022)ACT>TCT	p.T2674S	CSMD1_uc011kwj.1_Missense_Mutation_p.T2003S|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2674	Extracellular (Potential).|Sushi 17.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGACATCGAGTTTCGCTGCCG	0.458													109	88					0	0	0	0	A	2876011	A	A	2876011	3	1	287	1	0	0	0	0	1	0	0	0	3961	1725	60	5	2753	5	CSMD1	8	2876011	Missense_Mutation	SNP	T	TCGA-DQ-5631-01A-01D-1870-08		2876011	143488011	39	53371											
DENND3	22898	broad.mit.edu	37	chr8	142146792	142146792	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagcccagaccagagcagtGgaagggcctcccggggcccc	9	2	15	15	1	0	2	0	0	0	2	1	4	1	3	6	4	2	1	6	4	2	0			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr8:142146792G>A	uc003yvy.2	+	2	325	c.47G>A	c.(46-48)TGG>TAG	p.W16*	DENND3_uc003yvw.1_Nonsense_Mutation_p.W29*|DENND3_uc003yvx.2_Nonsense_Mutation_p.W96*|DENND3_uc010mep.2_Nonsense_Mutation_p.W29*	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	16	UDENN.									ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CCAGAGCAGTGGAAGGGCCTC	0.647													3	30					0	0	0	0	A	142146792	A	A	142146792	4	1	287	1	0	0	0	0	0	1	0	0	4454	1357	47	4	49	4	DENND3	8	142146792	Nonsense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	139270781	142146792	4217230	40	53372											
ZNF707	286075	broad.mit.edu	37	chr8	144776477	144776477	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggactgcggcaaagccttccGgaccaaggagaacctcagcc	11	4	12	14	2	1	1	1	0	0	1	2	4	2	3	5	4	4	1	5	4	3	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr8:144776477G>A	uc003yze.3	+	7	1208	c.893G>A	c.(892-894)CGG>CAG	p.R298Q	ZNF707_uc010mfh.2_Missense_Mutation_p.R298Q|ZNF707_uc010mfi.2_Missense_Mutation_p.R298Q|ZNF707_uc003yzf.3_Missense_Mutation_p.R298Q|ZNF707_uc003yzh.3_Missense_Mutation_p.R225Q|ZNF707_uc011lkq.1_RNA|BREA2_uc010mfj.1_5'Flank	NM_173831	NP_776192	Q96C28	ZN707_HUMAN	zinc finger protein 707	298	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;5.6e-41)|Epithelial(56;1.02e-39)|all cancers(56;9.65e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AAAGCCTTCCGGACCAAGGAG	0.632													5	24					0	0	0	0	A	144776477	A	A	144776477	3	1	287	1	0	0	0	0	1	0	0	0	18178	1116	39	1	907	1	ZNF707	8	144776477	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	2629685	144776477	1587545	41	53373											
SCRIB	23513	broad.mit.edu	37	chr8	144893098	144893098	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggctgggtgggggctgctgGggcagcaagtagcaggtgag	7	6	22	6	0	0	1	0	1	0	0	0	1	0	1	0	7	3	7	0	7	2	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr8:144893098G>A	uc003yzp.1	-	11	1258	c.1251C>T	c.(1249-1251)CCC>CCT	p.P417P	SCRIB_uc003yzo.1_Silent_p.P417P	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	417	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGGGCTGCTGGGGCAGCAAGT	0.667													5	22					0	0	0	0	A	144893098	A	A	144893098	2	1	287	1	0	0	0	0	0	0	0	1	14002	1219	43	4		4	SCRIB	8	144893098	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	116621	144893098	1470924	42	53374											
NANS	54187	broad.mit.edu	37	chr9	100843365	100843365	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agatggcctgcaatgagaagGtgtgtcctgccggactctac	9	9	13	10	1	1	2	0	1	1	2	2	4	2	3	3	3	3	1	3	3	3	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr9:100843365G>T	uc004ayb.2	+	6	1512	c.870_splice	c.e6+1	p.K290_splice	NANS_uc004ayc.2_Splice_Site_p.K290_splice|TRIM14_uc004ayd.2_Intron|NANS_uc004aye.1_Missense_Mutation_p.V139L|TRIM14_uc004ayf.1_3'UTR	NM_018946	NP_061819	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid phosphate synthase						lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CAATGAGAAGGTGTGTCCTGC	0.622													13	31					1.36491e-13	1.53002e-13	1	0	T	100843365	T	T	100843365	5	4	287	1	0	0	0	0	0	0	1	0	10208	1275	44	4	889	4	NANS	9	100843365	Splice_Site	SNP	G	TCGA-DQ-5631-01A-01D-1870-08		100843365	40370066	43	53375											
LRRC8A	56262	broad.mit.edu	37	chr9	131670491	131670491	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctacggcgctccctcaagAagtactcgtttgagtcgatc	8	11	10	12	4	1	2	1	1	0	1	5	3	2	2	1	1	3	4	1	1	4	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr9:131670491A>C	uc004bwl.3	+	3	1302	c.1048A>C	c.(1048-1050)AAG>CAG	p.K350Q	LRRC8A_uc010myp.2_Missense_Mutation_p.K350Q|LRRC8A_uc010myq.2_Missense_Mutation_p.K350Q	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	350					pre-B cell differentiation	integral to membrane					0						CTCCCTCAAGAAGTACTCGTT	0.522													6	38					0	0	0	0	C	131670491	C	C	131670491	3	2	287	1	0	0	0	0	1	0	0	0	9071	247	9	5	1050	5	LRRC8A	9	131670491	Missense_Mutation	SNP	A	TCGA-DQ-5631-01A-01D-1870-08	30827126	131670491	9542940	44	53376											
NOTCH1	4851	broad.mit.edu	37	chr9	139412327	139412327	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccgtgtagccctgcagacActggcactcgaaggagccca	9	5	12	15	2	0	1	0	0	0	1	1	3	0	2	3	2	3	3	3	2	2	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr9:139412327A>G	uc004chz.2	-	8	1318	c.1318T>C	c.(1318-1320)TGT>CGT	p.C440R		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	440	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCCTGCAGACACTGGCACTCG	0.657			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			9	29					0	0	0	0	G	139412327	G	G	139412327	3	3	287	1	0	0	0	0	1	0	0	0	10601	159	6	5	6457	5	NOTCH1	9	139412327	Missense_Mutation	SNP	A	TCGA-DQ-5631-01A-01D-1870-08	7741836	139412327	1801104	45	53377											
GTPBP4	23560	broad.mit.edu	37	chr10	1046661	1046661	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gaccaccctctggaggatagGaacaccatcgagatgcaggc	12	5	12	12	1	1	1	0	0	1	1	2	6	1	4	3	4	2	1	3	4	2	1	rs138136568		TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr10:1046661G>A	uc001ift.2	+	7	770	c.699G>A	c.(697-699)AGG>AGA	p.R233R	GTPBP4_uc010qac.1_Silent_p.R24R|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Silent_p.R117R|GTPBP4_uc010qae.1_Silent_p.R186R	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	233					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		TGGAGGATAGGAACACCATCG	0.567													7	24					0	0	0	0	A	1046661	A	A	1046661	2	1	287	1	0	0	0	0	0	0	0	1	6921	1165	41	2		2	GTPBP4	10	1046661	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08		1046661	134488086	46	53378											
DNAJC1	64215	broad.mit.edu	37	chr10	22048519	22048519	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcctggaattctgaactgtCgatttgagttcggagagtct	8	13	13	7	2	2	3	0	2	2	1	4	6	2	4	1	3	1	1	1	3	2	3	rs148336959		TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr10:22048519C>T	uc001irc.2	-	11	1463	c.1176G>A	c.(1174-1176)TCG>TCA	p.S392S	DNAJC1_uc001ird.2_Silent_p.S278S	NM_022365	NP_071760	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	392	Cytoplasmic (By similarity).				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			lung(1)	1		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				TCTGAACTGTCGATTTGAGTT	0.562													14	30					0	0	0	0	T	22048519	T	T	22048519	2	4	287	1	0	0	0	0	0	0	0	1	4650	871	31	1		1	DNAJC1	10	22048519	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	21001858	22048519	113486228	47	53379											
ZNF365	22891	broad.mit.edu	37	chr10	64416233	64416233	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaggacgtcttaggactcCaggactttgagaggtgggtg	10	9	16	6	1	1	2	0	1	1	2	2	6	2	5	1	5	0	0	1	5	2	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr10:64416233C>T	uc001jmd.1	+	5	803	c.469C>T	c.(469-471)CAG>TAG	p.Q157*	ZNF365_uc001jmc.2_Nonsense_Mutation_p.Q403*|ZNF365_uc001jme.1_RNA|ZNF365_uc001jmf.1_Intron|ZNF365_uc009xpg.1_RNA	NM_199452	NP_955524	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform D	157										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					cttaggactccaggactttga	0.02													9	28					0	0	0	0	T	64416233	T	T	64416233	4	4	287	1	0	0	0	0	0	1	0	0	17936	595	21	4	1961	4	ZNF365	10	64416233	Nonsense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	42367714	64416233	71118514	48	53380											
GOT1	2805	broad.mit.edu	37	chr10	101165514	101165514	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctctgaaggggcagttaccTtcatgacagaagcaatctgc	11	9	11	10	0	3	3	1	2	2	1	3	3	3	3	1	2	3	4	1	2	4	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr10:101165514T>G	uc001kpr.2	-	5	849	c.641A>C	c.(640-642)AAG>ACG	p.K214T	GOT1_uc009xwh.2_RNA|GOT1_uc001kpq.1_5'UTR	NM_002079	NP_002070	P17174	AATC_HUMAN	aspartate aminotransferase 1	214					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding				0		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GGCAGTTACCTTCATGACAGA	0.353													5	56					0	0	0	0	G	101165514	G	G	101165514	3	3	287	1	0	0	0	0	1	0	0	0	6616	1623	56	5	620	5	GOT1	10	101165514	Missense_Mutation	SNP	T	TCGA-DQ-5631-01A-01D-1870-08	36749281	101165514	34369233	49	53381											
BLOC1S2	282991	broad.mit.edu	37	chr10	102045960	102045960	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcttcctcagctgtctccacGgcggcatcgtctgggccaag	5	9	12	15	3	3	0	1	0	2	0	6	0	4	0	3	3	1	3	3	3	1	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr10:102045960G>C	uc001kqw.1	-	2	89	c.66C>G	c.(64-66)GCC>GCG	p.A22A	BLOC1S2_uc001kqv.1_5'UTR	NM_173809	NP_776170	Q6QNY1	BL1S2_HUMAN	biogenesis of lysosome-related organelles	22					melanosome organization|microtubule nucleation|platelet dense granule organization|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of apoptosis	BLOC-1 complex|centrosome|gamma-tubulin complex|nucleus	gamma-tubulin binding|identical protein binding|protein C-terminus binding			ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.44e-10)|all cancers(201;1.97e-08)		CTGTCTCCACGGCGGCATCGT	0.572													8	39					0	0	0	0	C	102045960	C	C	102045960	2	2	287	1	0	0	0	0	0	0	0	1	1452	1103	39	3		3	BLOC1S2	10	102045960	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	880446	102045960	33488787	50	53382											
LRDD	55367	broad.mit.edu	37	chr11	803327	803327	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcccccagtgctgggggcaGcgtctgcaggcggttgtgtg	3	8	19	11	2	1	0	0	0	1	0	1	0	1	0	2	5	3	4	2	5	0	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:803327G>A	uc001lro.1	-	3	698	c.556C>T	c.(556-558)CTG>TTG	p.L186L	LRDD_uc009yck.1_5'Flank|LRDD_uc001lrk.1_Silent_p.L186L|LRDD_uc001lrl.1_Silent_p.L40L|LRDD_uc001lrm.1_5'UTR|LRDD_uc001lrn.1_Silent_p.L40L|LRDD_uc001lrp.1_5'UTR	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	186	LRR 3.				apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCTGGGGGCAGCGTCTGCAGG	0.642													20	48					0	0	0	0	A	803327	A	A	803327	2	1	287	1	0	0	0	0	0	0	0	1	8986	962	34	4		4	LRDD	11	803327	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08		803327	134203189	51	53383											
TRIM5	85363	broad.mit.edu	37	chr11	5699528	5699528	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgcaccatctcagtttcaGagttcgtaaggcttttcaga	9	13	9	10	1	3	2	3	0	1	2	5	2	3	2	1	1	1	6	1	1	1	5	rs140632799		TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:5699528G>C	uc001mbm.1	-	4	907	c.650C>G	c.(649-651)TCT>TGT	p.S217C	TRIM5_uc001mbq.1_Missense_Mutation_p.S217C|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Missense_Mutation_p.S217C|TRIM5_uc001mbo.2_Missense_Mutation_p.S217C|TRIM5_uc001mbp.2_Missense_Mutation_p.S217C	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	217	Potential.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		CTCAGTTTCAGAGTTCGTAAG	0.512													19	79					0	0	0	0	C	5699528	C	C	5699528	3	2	287	1	0	0	0	0	1	0	0	0	16592	942	33	2	1090	2	TRIM5	11	5699528	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	4896201	5699528	129306988	52	53384											
OLFML1	283298	broad.mit.edu	37	chr11	7530749	7530749	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaaggtgtacttattaattgGatccagaaacaacactgttt	15	13	7	6	0	0	1	0	0	0	1	1	2	1	2	1	2	3	2	1	2	6	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:7530749G>C	uc001mfi.2	+	3	891	c.539G>C	c.(538-540)GGA>GCA	p.G180A	OLFML1_uc010raz.1_Missense_Mutation_p.G44A|OLFML1_uc010rba.1_Missense_Mutation_p.G180A	NM_198474	NP_940876	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1 precursor	180	Olfactomedin-like.					extracellular region				ovary(2)	2				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		TTATTAATTGGATCCAGAAAC	0.423													9	58					0	0	0	0	C	7530749	C	C	7530749	3	2	287	1	0	0	0	0	1	0	0	0	10910	1174	41	2	549	2	OLFML1	11	7530749	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	1831221	7530749	127475767	53	53385											
SCUBE2	57758	broad.mit.edu	37	chr11	9096045	9096045	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taccttccgagcggtgaatgCaggtgtgctgattgtcactc	7	12	12	10	2	1	2	1	2	0	0	3	3	2	2	2	2	4	2	2	2	2	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:9096045C>T	uc001mhh.1	-	4	580	c.500G>A	c.(499-501)TGC>TAC	p.C167Y	SCUBE2_uc001mhi.1_Missense_Mutation_p.C167Y|SCUBE2_uc001mhj.1_Missense_Mutation_p.C167Y	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	167	EGF-like 3; calcium-binding (Potential).					extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		GCGGTGAATGCAGGTGTGCTG	0.572													4	109					0	0	0	0	T	9096045	T	T	9096045	3	4	287	1	0	0	0	0	1	0	0	0	14010	710	25	4	2666	4	SCUBE2	11	9096045	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	1565296	9096045	125910471	54	53386											
MRGPRX4	117196	broad.mit.edu	37	chr11	18195018	18195018	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcaacctggccgcagcagActtcctcttcctcagcttcc	6	10	6	19	1	3	1	2	0	1	1	6	1	6	1	6	1	3	3	6	1	1	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:18195018A>G	uc001mnv.1	+	1	635	c.215A>G	c.(214-216)GAC>GGC	p.D72G		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	72	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GCCGCAGCAGACTTCCTCTTC	0.532													15	76					0	0	0	0	G	18195018	G	G	18195018	3	3	287	1	0	0	0	0	1	0	0	0	9822	275	10	5	217	5	MRGPRX4	11	18195018	Missense_Mutation	SNP	A	TCGA-DQ-5631-01A-01D-1870-08	9098973	18195018	116811498	55	53387											
C11orf66	220004	broad.mit.edu	37	chr11	61249785	61249785	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccgttacccctctggcaggtCgggaggatttcaagccccgt	6	9	12	14	3	2	0	1	0	1	0	3	2	2	2	5	4	2	2	5	4	2	2	rs34626255		TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:61249785C>T	uc001nru.1	+	3	237	c.112C>T	c.(112-114)CGG>TGG	p.R38W	C11orf66_uc009ynq.1_Missense_Mutation_p.R38W	NM_145017	NP_659454	Q7Z5V6	CK066_HUMAN	IIIG9 protein	38										ovary(1)	1						TCTGGCAGGTCGGGAGGATTT	0.612											OREG0021002	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	66					0	0	0	0	T	61249785	T	T	61249785	3	4	287	1	0	0	0	0	1	0	0	0	1662	875	31	1	118	1	C11orf66	11	61249785	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	43054767	61249785	73756731	56	53388											
RSF1	51773	broad.mit.edu	37	chr11	77378520	77378520	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctcatcatcttcagagttCttggacaaatagctctctag	11	13	7	10	0	6	1	3	0	3	1	7	2	6	2	0	1	2	3	0	1	3	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:77378520C>T	uc001oyn.2	-	16	3888	c.3768G>A	c.(3766-3768)AAG>AAA	p.K1256K	RSF1_uc001oym.2_Silent_p.K1004K	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	1256					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			CTTCAGAGTTCTTGGACAAAT	0.448													7	131					0	0	0	0	T	77378520	T	T	77378520	2	4	287	1	0	0	0	0	0	0	0	1	13764	912	32	2		2	RSF1	11	77378520	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	16128735	77378520	57627996	57	53389											
USP35	57558	broad.mit.edu	37	chr11	77911847	77911847	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtatgagcctgtcatggaggCcatcaaggtgagcgacagtc	10	8	14	9	1	2	2	2	2	0	0	3	4	2	3	2	3	2	1	2	3	2	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:77911847C>T	uc009yva.1	+	6	1436	c.1190C>T	c.(1189-1191)GCC>GTC	p.A397V	USP35_uc001oze.2_Missense_Mutation_p.A153V|USP35_uc001ozc.2_Intron|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_Missense_Mutation_p.P7S|USP35_uc001ozf.2_Missense_Mutation_p.A128V	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	397					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			GTCATGGAGGCCATCAAGGTG	0.622													9	62					0	0	0	0	T	77911847	T	T	77911847	3	4	287	1	0	0	0	0	1	0	0	0	17134	739	26	4	1208	4	USP35	11	77911847	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	533327	77911847	57094669	58	53390											
USP35	57558	broad.mit.edu	37	chr11	77921356	77921356	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctttcgacctgcgcaccatgCggcgccgcaagatcctggat	7	8	11	15	5	0	1	0	0	0	1	2	3	1	2	4	2	2	2	4	2	1	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:77921356C>T	uc009yva.1	+	10	2701	c.2455C>T	c.(2455-2457)CGG>TGG	p.R819W	USP35_uc001oze.2_Missense_Mutation_p.R575W|USP35_uc001ozc.2_Missense_Mutation_p.R387W|USP35_uc010rsp.1_Missense_Mutation_p.R251W|USP35_uc001ozd.2_Missense_Mutation_p.R430W|USP35_uc001ozf.2_Missense_Mutation_p.R550W	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	819					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			GCGCACCATGCGGCGCCGCAA	0.647													4	136					0	0	0	0	T	77921356	T	T	77921356	3	4	287	1	0	0	0	0	1	0	0	0	17134	759	27	1	2489	1	USP35	11	77921356	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	9509	77921356	57085160	59	53391											
FAT3	120114	broad.mit.edu	37	chr11	92600371	92600371	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agctgcactggcctgccatcGgggggtgagtgtggctacgc	5	8	17	11	2	0	1	0	1	0	0	1	1	0	1	2	5	4	3	2	5	1	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:92600371G>A	uc001pdj.3	+	21	12140	c.12123G>A	c.(12121-12123)TCG>TCA	p.S4041S	FAT3_uc001pdi.3_Silent_p.S481S	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4041	EGF-like 2.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCCTGCCATCGGGGGGTGAGT	0.667										TCGA Ovarian(4;0.039)			3	14					0	0	0	0	A	92600371	A	A	92600371	2	1	287	1	0	0	0	0	0	0	0	1	5723	1103	39	1		1	FAT3	11	92600371	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	14679015	92600371	42406145	60	53392											
HEPHL1	341208	broad.mit.edu	37	chr11	93803697	93803697	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcagtggtcttcctctaaaCgcctctggcaggtaagcacc	8	11	9	13	1	4	0	1	0	3	0	5	0	5	0	3	3	2	3	3	3	3	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:93803697C>T	uc001pep.2	+	6	1378	c.1221C>T	c.(1219-1221)AAC>AAT	p.N407N	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	407	Plastocyanin-like 3.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TTCCTCTAAACGCCTCTGGCA	0.433													5	31					0	0	0	0	T	93803697	T	T	93803697	2	4	287	1	0	0	0	0	0	0	0	1	7094	535	19	1		1	HEPHL1	11	93803697	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	1203326	93803697	41202819	61	53393											
PPP2R1B	5519	broad.mit.edu	37	chr11	111630634	111630634	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atttggaagcagcagcacgtCgtaccattggtgtgtcatct	9	12	11	9	2	2	0	1	0	1	0	3	1	2	1	1	2	4	4	1	2	2	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:111630634C>G	uc001plx.1	-	5	665	c.581G>C	c.(580-582)CGA>CCA	p.R194P	PPP2R1B_uc001plw.1_Missense_Mutation_p.R194P|PPP2R1B_uc010rwi.1_Missense_Mutation_p.R130P|PPP2R1B_uc010rwj.1_Missense_Mutation_p.R33P|PPP2R1B_uc010rwk.1_Missense_Mutation_p.R194P|PPP2R1B_uc010rwl.1_Intron	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	194	HEAT 5.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		AGCAGCACGTCGTACCATTGG	0.413													8	58					0	0	0	0	G	111630634	G	G	111630634	3	3	287	1	0	0	0	0	1	0	0	0	12443	884	31	3	1491	3	PPP2R1B	11	111630634	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	17826937	111630634	23375882	62	53394											
RBM7	10179	broad.mit.edu	37	chr11	114271421	114271421	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cggcggcggcggaagcggatCgcactctctttgtgggcaac	6	7	16	12	6	1	0	0	0	1	0	3	2	1	2	0	6	2	2	0	6	2	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr11:114271421C>G	uc001pov.2	+	1	38	c.28C>G	c.(28-30)CGC>GGC	p.R10G	C11orf71_uc001pot.1_5'Flank|C11orf71_uc001pou.3_5'Flank|RBM7_uc001pow.2_Missense_Mutation_p.R10G|RBM7_uc001pox.2_Translation_Start_Site	NM_016090	NP_057174	Q9Y580	RBM7_HUMAN	RNA binding motif protein 7	10	RRM.				meiosis		nucleotide binding|protein binding|RNA binding			ovary(2)	2		all_cancers(61;5.06e-12)|all_epithelial(67;5.3e-06)|all_hematologic(158;7.68e-05)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.56e-06)|Epithelial(105;4.17e-05)|all cancers(92;0.000348)		GGAAGCGGATCGCACTCTCTT	0.627													29	119					0	0	0	0	G	114271421	G	G	114271421	3	3	287	1	0	0	0	0	1	0	0	0	13210	884	31	3	30	3	RBM7	11	114271421	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	2640787	114271421	20735095	63	53395											
ERBB3	2065	broad.mit.edu	37	chr12	56494868	56494868	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgcagtttctgggagcagTgaacggtgcccccgtccagt	6	10	13	12	2	2	1	0	1	2	0	3	2	3	2	3	2	4	3	3	2	1	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr12:56494868T>C	uc001sjh.2	+	27	3418	c.3225T>C	c.(3223-3225)AGT>AGC	p.S1075S	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Silent_p.S432S|ERBB3_uc010sqc.1_Silent_p.S1016S|ERBB3_uc009zok.2_Silent_p.S340S|ERBB3_uc001sjk.2_Silent_p.S316S|ERBB3_uc001sjl.2_Silent_p.S195S	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	1075	Cytoplasmic (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CTGGGAGCAGTGAACGGTGCC	0.483													6	34					0	0	0	0	C	56494868	C	C	56494868	2	2	287	1	0	0	0	0	0	0	0	1	5232	1693	59	5		5	ERBB3	12	56494868	Silent	SNP	T	TCGA-DQ-5631-01A-01D-1870-08		56494868	77357027	64	53396											
DGKH	160851	broad.mit.edu	37	chr13	42830545	42830545	+	RNA	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagcgtatgacaaggcagcaAagattgctaagacagcacac	16	6	10	9	1	0	3	0	1	0	2	0	3	0	3	0	1	4	5	0	1	5	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr13:42830545A>G	uc001uyp.2	+	32		c.4325A>G						Q86XP1	DGKH_HUMAN	Homo sapiens DGKH-1 mRNA for diacylglycerol kinase eta1, complete cds.						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		CAAGGCAGCAAAGATTGCTAA	0.413													9	113					0	0	0	0	G	42830545	G	G	42830545	1	3	287	0	1	0	0	0	0	0	0	0	4492	29	1	5		5	DGKH	13	42830545	RNA	SNP	A	TCGA-DQ-5631-01A-01D-1870-08		42830545	72339333	65	53397											
DACH1	1602	broad.mit.edu	37	chr13	72063173	72063173	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gatggaagacagtccatcagGaaacagaaaaggagatggaa	19	4	13	5	0	1	3	1	0	0	3	2	8	2	6	1	4	1	0	1	4	5	0			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr13:72063173G>A	uc010thn.1	-	8	2101	c.1678C>T	c.(1678-1680)CCT>TCT	p.P560S	DACH1_uc010tho.1_Missense_Mutation_p.P412S|DACH1_uc010thp.1_Missense_Mutation_p.P358S	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	612					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGTCCATCAGGAAACAGAAAA	0.463													23	280					0	0	0	0	A	72063173	A	A	72063173	3	1	287	1	0	0	0	0	1	0	0	0	4237	1174	41	2	462	2	DACH1	13	72063173	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	29232628	72063173	43106705	66	53398											
RPGRIP1	57096	broad.mit.edu	37	chr14	21795884	21795884	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgagagcttcctgaaacCagaagctcagactaagggga	13	6	11	11	0	1	4	1	2	0	3	2	6	2	5	3	2	3	2	3	2	3	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr14:21795884C>A	uc001wag.2	+	17	2813	c.2813C>A	c.(2812-2814)CCA>CAA	p.P938Q	RPGRIP1_uc001wah.2_Missense_Mutation_p.P580Q|RPGRIP1_uc001wai.2_Missense_Mutation_p.P264Q|RPGRIP1_uc001wak.2_Missense_Mutation_p.P413Q|RPGRIP1_uc010aim.2_Missense_Mutation_p.P321Q|RPGRIP1_uc001wal.2_Missense_Mutation_p.P297Q|RPGRIP1_uc001wam.2_Missense_Mutation_p.P255Q	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	938					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TTCCTGAAACCAGAAGCTCAG	0.473													10	39					7.48243e-07	8.25443e-07	1	0	A	21795884	A	A	21795884	3	1	287	1	0	0	0	0	1	0	0	0	13614	594	21	4	2879	4	RPGRIP1	14	21795884	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08		21795884	85553656	67	53399											
SOS2	6655	broad.mit.edu	37	chr14	50585274	50585274	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ccttggagagggtgtgctagGaggagtgcttggcgaatttg	7	11	18	5	1	0	1	0	0	0	1	0	5	0	3	1	5	2	2	1	5	2	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr14:50585274G>C	uc001wxs.3	-	23	3885	c.3787C>G	c.(3787-3789)CCT>GCT	p.P1263A	SOS2_uc010ans.2_Missense_Mutation_p.P98A|SOS2_uc010tql.1_Missense_Mutation_p.P1230A|C14orf138_uc001wxn.1_5'Flank|C14orf138_uc001wxo.1_5'Flank|C14orf138_uc001wxp.1_5'Flank|C14orf138_uc001wxq.1_5'Flank	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1263					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					GGTGTGCTAGGAGGAGTGCTT	0.517													11	45					0	0	0	0	C	50585274	C	C	50585274	3	2	287	1	0	0	0	0	1	0	0	0	15001	1174	41	2	215	2	SOS2	14	50585274	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	28789390	50585274	56764266	68	53400											
SOS2	6655	broad.mit.edu	37	chr14	50626720	50626720	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctttgccttcccatccatcGatatttttctgaatttcatt	7	20	3	11	1	3	1	1	1	2	0	6	2	5	1	3	0	1	0	3	0	2	7	rs8010578		TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr14:50626720G>A	uc001wxs.3	-	10	1379	c.1281C>T	c.(1279-1281)ATC>ATT	p.I427I	SOS2_uc010tql.1_Silent_p.I394I|SOS2_uc010tqm.1_RNA|SOS2_uc001wxt.2_Silent_p.I115I	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	427					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					CCCATCCATCGATATTTTTCT	0.358													32	57					0	0	0	0	A	50626720	A	A	50626720	2	1	287	1	0	0	0	0	0	0	0	1	15001	1048	37	1		1	SOS2	14	50626720	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	41446	50626720	56722820	69	53401											
C14orf129	51527	broad.mit.edu	37	chr14	96851943	96851943	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tactccttgttggatacactCagccccgcctaccgagaagc	9	9	8	15	2	1	1	1	0	0	1	2	3	2	2	5	1	5	1	5	1	4	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr14:96851943C>G	uc001yfj.3	+	4	487	c.342C>G	c.(340-342)CTC>CTG	p.L114L	C14orf129_uc001yfl.2_Silent_p.L114L	NM_016472	NP_057556	Q9P0R6	GSKIP_HUMAN	chromosome 14 open reading frame 129	114						cytoplasm	protein binding				0		Melanoma(154;0.226)		Epithelial(152;0.109)|COAD - Colon adenocarcinoma(157;0.205)		TGGATACACTCAGCCCCGCCT	0.448													29	56					0	0	0	0	G	96851943	G	G	96851943	2	3	287	1	0	0	0	0	0	0	0	1	1750	813	29	2		2	C14orf129	14	96851943	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	46225223	96851943	10497597	70	53402											
DUOXA1	90527	broad.mit.edu	37	chr15	45410265	45410265	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagggaaagtctcctggggcGatctgtaaataaaccttttt	11	12	10	8	1	2	0	0	0	2	0	3	2	2	1	2	3	1	1	2	3	5	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr15:45410265G>A	uc001zup.2	-	10	1394	c.994C>T	c.(994-996)CGC>TGC	p.R332C	DUOXA2_uc001zuo.2_3'UTR|DUOXA2_uc010beb.2_RNA|DUOXA1_uc010uem.1_Missense_Mutation_p.R287C|DUOXA1_uc010bec.2_Missense_Mutation_p.R332C	NM_144565	NP_653166	Q1HG43	DOXA1_HUMAN	Numb-interacting protein	Error:Variant_position_missing_in_Q1HG43_after_alignment					protein transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		CTCCTGGGGCGATCTGTAAAT	0.552											OREG0023102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	22					0	0	0	0	A	45410265	A	A	45410265	3	1	287	1	0	0	0	0	1	0	0	0	4824	1058	37	1	465	1	DUOXA1	15	45410265	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08		45410265	57121127	71	53403											
CP110	9738	broad.mit.edu	37	chr16	19553369	19553369	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcggactcactccatacttCaaattcaaatagttctggta	13	12	6	10	1	4	0	3	0	1	0	5	1	5	1	1	2	2	2	1	2	5	6			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr16:19553369C>G	uc002dgl.3	+	6	2457	c.2210C>G	c.(2209-2211)TCA>TGA	p.S737*	CP110_uc002dgk.3_Nonsense_Mutation_p.S737*			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	737					centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						CTCCATACTTCAAATTCAAAT	0.338													23	59					0	0	0	0	G	19553369	G	G	19553369	4	3	287	1	0	0	0	0	0	1	0	0	3803	838	29	2	2228	2	CP110	16	19553369	Nonsense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08		19553369	70801384	72	53404											
HEATR3	55027	broad.mit.edu	37	chr16	50138923	50138923	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caatgtgaaaatgaatttgcGaagatttattgcttatcaag	15	14	8	4	1	1	3	1	2	0	1	1	4	1	3	0	0	2	1	0	0	8	5	rs137897639		TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr16:50138923G>A	uc002efw.2	+	15	2156	c.1994G>A	c.(1993-1995)CGA>CAA	p.R665Q	HEATR3_uc002efx.2_Missense_Mutation_p.R579Q|uc002efy.2_5'Flank	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	665							binding			ovary(1)|skin(1)	2						ATGAATTTGCGAAGATTTATT	0.333													37	64					0	0	0	0	A	50138923	A	A	50138923	3	1	287	1	0	0	0	0	1	0	0	0	7068	1058	37	1	2052	1	HEATR3	16	50138923	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	30585554	50138923	40215830	73	53405											
LRRC50	123872	broad.mit.edu	37	chr16	84188262	84188262	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcaatggaatacagaaaatcGaaaacctggaggcccaaact	18	5	9	9	1	0	1	0	0	0	1	1	4	0	3	2	3	3	1	2	3	8	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr16:84188262G>A	uc002fhl.3	+	4	614	c.433G>A	c.(433-435)GAA>AAA	p.E145K	LRRC50_uc010chi.1_RNA	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	145	LRR 2.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						ACAGAAAATCGAAAACCTGGA	0.473									Kartagener_syndrome				11	44					0	0	0	0	A	84188262	A	A	84188262	3	1	287	1	0	0	0	0	1	0	0	0	9059	1059	37	1	447	1	LRRC50	16	84188262	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	34049339	84188262	6166491	74	53406											
ENO3	2027	broad.mit.edu	37	chr17	4856404	4856404	+	Frame_Shift_Del	DEL	G	-	-																															ggccctgctctgctgcaaaaGgcaagtggggaagcccgctc																										TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:4856404delG	uc002gab.3	+	4	334	c.240delG	c.(238-240)AAGfs	p.K80fs	ENO3_uc010vsr.1_5'UTR|ENO3_uc002gac.3_Frame_Shift_Del_p.K80fs|ENO3_uc010vss.1_Intron|ENO3_uc010vst.1_5'Flank	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	80					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1						TGCTGCAAAAGGCAAGTGGGG	0.577													---	---	---								-	4856404	-	-	4856404	7	5	287	1	0	1	0	1	0	0	0	0	5147	1014	35	0	250	0	ENO3	17	4856404	Frame_Shift_Del	DEL	G	TCGA-DQ-5631-01A-01D-1870-08		4856404	76338806	75	53407											
ZBTB4	57659	broad.mit.edu	37	chr17	7370078	7370078	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgagctggcgcaggacggCgggggcatgggacgggtccg	6	5	21	9	5	0	1	0	1	0	0	1	3	1	3	1	7	1	3	1	7	0	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:7370078C>T	uc002ghc.3	-	3	293	c.43G>A	c.(43-45)GCC>ACC	p.A15T	ZBTB4_uc002ghd.3_Missense_Mutation_p.A15T	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		CGCAGGACGGCGGGGGCATGG	0.657													5	9					0	0	0	0	T	7370078	T	T	7370078	3	4	287	1	0	0	0	0	1	0	0	0	17608	768	27	1	3006	1	ZBTB4	17	7370078	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	2513674	7370078	73825132	76	53408											
TP53	7157	broad.mit.edu	37	chr17	7574021	7574021	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggaacatctcgaagcgctCacgcccacggatctgcagca	10	6	10	15	5	3	0	1	0	2	0	5	3	3	2	1	2	4	3	1	2	2	0			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:7574021C>A	uc002gim.2	-	10	1200	c.1006G>T	c.(1006-1008)GAG>TAG	p.E336*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.E204*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.E336*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	336	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.E336*(5)|p.I332fs*5(1)|p.E336fs*12(1)|p.?(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGAAGCGCTCACGCCCACGG	0.438		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	35					0.00198382	0.00212116	1	0	A	7574021	A	A	7574021	4	1	287	1	0	0	0	0	0	1	0	0	16448	835	29	2	183	2	TP53	17	7574021	Nonsense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	203943	7574021	73621189	77	53409											
TP53	7157	broad.mit.edu	37	chr17	7577548	7577548	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgggcctccggttcatgcCgcccatgcaggaactgttac	7	9	12	13	2	1	0	1	0	0	0	2	2	2	1	4	3	4	3	4	3	2	2	rs28934575		TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	56					0	0	0	0	T	7577548	T	T	7577548	3	4	287	1	0	0	0	0	1	0	0	0	16448	652	23	1	557	1	TP53	17	7577548	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	3527	7577548	73617662	78	53410											
AURKB	9212	broad.mit.edu	37	chr17	8110609	8110609	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaaatggcttttcttctcccGagccaagtacacgtttccaa	10	12	7	12	2	2	0	0	0	2	0	4	2	3	0	3	1	2	3	3	1	4	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:8110609G>A	uc002gkm.2	-	5	344	c.283C>T	c.(283-285)CGG>TGG	p.R95W	AURKB_uc010cnu.2_5'UTR|AURKB_uc002gkn.2_Missense_Mutation_p.R96W|AURKB_uc010vuu.1_Missense_Mutation_p.R54W|AURKB_uc002gko.2_RNA	NM_004217	NP_004208	Q96GD4	AURKB_HUMAN	aurora kinase B	95	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic prometaphase|protein localization to kinetochore	chromosome passenger complex|condensed nuclear chromosome, centromeric region|cytosol|spindle	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(1)|central_nervous_system(1)	4						TTCTTCTCCCGAGCCAAGTAC	0.517													13	30					0	0	0	0	A	8110609	A	A	8110609	3	1	287	1	0	0	0	0	1	0	0	0	1225	1057	37	1	771	1	AURKB	17	8110609	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	533061	8110609	73084601	79	53411											
MYH13	8735	broad.mit.edu	37	chr17	10248886	10248886	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgggtgaccatccacaggaaCatcttctcgtagacggcttt	9	10	10	12	3	2	2	0	1	2	1	4	3	3	3	2	3	1	2	2	3	2	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:10248886C>T	uc002gmk.1	-	14	1401	c.1311G>A	c.(1309-1311)ATG>ATA	p.M437I	MYH13_uc010vvf.1_Missense_Mutation_p.M112I	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	437	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCCACAGGAACATCTTCTCGT	0.522													33	115					0	0	0	0	T	10248886	T	T	10248886	3	4	287	1	0	0	0	0	1	0	0	0	10085	478	17	4	4617	4	MYH13	17	10248886	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	2138277	10248886	70946324	80	53412											
MYH4	4622	broad.mit.edu	37	chr17	10364306	10364306	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgttcccataatgcatcacGgctccagtgagcttgtaaat	11	12	8	10	1	1	1	1	1	0	0	3	1	3	1	2	1	2	5	2	1	3	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:10364306G>A	uc002gmn.2	-	12	1185	c.1074C>T	c.(1072-1074)GCC>GCT	p.A358A	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	358	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AATGCATCACGGCTCCAGTGA	0.483													40	123					0	0	0	0	A	10364306	A	A	10364306	2	1	287	1	0	0	0	0	0	0	0	1	10090	1103	39	1		1	MYH4	17	10364306	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	115420	10364306	70830904	81	53413											
FBXW10	10517	broad.mit.edu	37	chr17	18659468	18659468	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcgcattctctctgacacGtaggtactggggtcagaatc	8	12	11	10	2	3	2	1	1	2	1	6	2	3	2	0	3	1	4	0	3	3	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:18659468G>A	uc002guk.2	+	6	1464	c.1232_splice	c.e6+1	p.T411_splice	FBXW10_uc002guj.2_Splice_Site_p.T411_splice|FBXW10_uc002gul.2_Splice_Site_p.T440_splice|FBXW10_uc010cqh.1_Splice_Site_p.T411_splice	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10											ovary(1)	1						TCTCTGACACGTAGGTACTGG	0.493													9	29					0	0	0	0	A	18659468	A	A	18659468	5	1	287	1	0	0	0	0	0	0	1	0	5795	1159	40	1	1255	1	FBXW10	17	18659468	Splice_Site	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	8295162	18659468	62535742	82	53414											
STAT3	6774	broad.mit.edu	37	chr17	40485969	40485969	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccagcatcggccggtgctgtAcaatggggtcccctttgtag	6	10	13	12	2	0	0	0	0	0	0	2	0	1	0	4	4	3	4	4	4	3	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:40485969A>G	uc002hzl.1	-	9	1136	c.896T>C	c.(895-897)GTA>GCA	p.V299A	STAT3_uc002hzk.1_Missense_Mutation_p.V299A|STAT3_uc002hzm.1_Missense_Mutation_p.V299A|STAT3_uc010wgh.1_Missense_Mutation_p.V201A|STAT3_uc002hzn.1_Missense_Mutation_p.V299A	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	299					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		CCGGTGCTGTACAATGGGGTC	0.428									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				18	53					0	0	0	0	G	40485969	G	G	40485969	3	3	287	1	0	0	0	0	1	0	0	0	15332	391	14	5	1480	5	STAT3	17	40485969	Missense_Mutation	SNP	A	TCGA-DQ-5631-01A-01D-1870-08	21826501	40485969	40709241	83	53415											
ITGA2B	3674	broad.mit.edu	37	chr17	42452040	42452040	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcacctgagcttcccctCggggcaggctgagcgggggc	5	6	15	15	2	1	2	1	2	0	0	3	2	2	2	3	5	2	3	3	5	0	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:42452040C>A	uc002igt.1	-	28	2962	c.2930G>T	c.(2929-2931)CGA>CTA	p.R977L	ITGA2B_uc002igu.1_3'UTR	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	977	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	AGCTTCCCCTCGGGGCAGGCT	0.632													12	43					2.61681e-11	2.9099e-11	1	0	A	42452040	A	A	42452040	3	1	287	1	0	0	0	0	1	0	0	0	7915	884	31	3	201	3	ITGA2B	17	42452040	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	1966071	42452040	38743170	84	53416											
CACNA1G	8913	broad.mit.edu	37	chr17	48685319	48685319	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtgtcggcagcaccaggaGgaagaggaggcccggcggcg	10	2	19	10	4	0	1	0	0	0	1	1	4	0	4	2	7	1	2	2	7	2	0			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:48685319G>A	uc002irk.1	+	25	5016	c.4644G>A	c.(4642-4644)GAG>GAA	p.E1548E	CACNA1G_uc002irj.1_Silent_p.E1525E|CACNA1G_uc002irl.1_Silent_p.E1525E|CACNA1G_uc002irm.1_Silent_p.E1525E|CACNA1G_uc002irn.1_Silent_p.E1525E|CACNA1G_uc002iro.1_Silent_p.E1525E|CACNA1G_uc002irp.1_Silent_p.E1548E|CACNA1G_uc002irq.1_Silent_p.E1525E|CACNA1G_uc002irr.1_Silent_p.E1548E|CACNA1G_uc002irs.1_Silent_p.E1548E|CACNA1G_uc002irt.1_Silent_p.E1548E|CACNA1G_uc002irv.1_Silent_p.E1548E|CACNA1G_uc002irw.1_Silent_p.E1525E|CACNA1G_uc002iru.1_Silent_p.E1525E|CACNA1G_uc002irx.1_Silent_p.E1461E|CACNA1G_uc002iry.1_Silent_p.E1461E|CACNA1G_uc002irz.1_Silent_p.E1461E|CACNA1G_uc002isa.1_Silent_p.E1427E|CACNA1G_uc002isb.1_Silent_p.E1461E|CACNA1G_uc002isc.1_Silent_p.E1461E|CACNA1G_uc002isd.1_Silent_p.E1461E|CACNA1G_uc002ise.1_Silent_p.E1427E|CACNA1G_uc002isf.1_Silent_p.E1461E|CACNA1G_uc002isg.1_Silent_p.E1427E|CACNA1G_uc002ish.1_Silent_p.E1427E|CACNA1G_uc002isi.1_Silent_p.E1404E	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1548	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AGCACCAGGAGGAAGAGGAGG	0.547													8	32					0	0	0	0	A	48685319	A	A	48685319	2	1	287	1	0	0	0	0	0	0	0	1	2556	991	35	4		4	CACNA1G	17	48685319	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	6233279	48685319	32509891	85	53417											
KIF2B	84643	broad.mit.edu	37	chr17	51902045	51902045	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtagatgtaaggccctacCatcgtggccactatccgatt	10	11	9	11	2	0	1	0	0	0	1	2	2	1	1	4	2	1	2	4	2	4	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:51902045C>A	uc002iua.2	+	1	1807	c.1651C>A	c.(1651-1653)CAT>AAT	p.H551N	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	551					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						AAGGCCCTACCATCGTGGCCA	0.398													17	38					5.3912e-06	5.85451e-06	1	0	A	51902045	A	A	51902045	3	1	287	1	0	0	0	0	1	0	0	0	8337	594	21	4	1653	4	KIF2B	17	51902045	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	3216726	51902045	29293165	86	53418											
C17orf71	55181	broad.mit.edu	37	chr17	57288727	57288727	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggaacccacagccttccCattttgaacttcctacttat	10	12	5	14	0	0	1	0	1	0	0	2	2	2	2	4	1	4	1	4	1	4	6			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:57288727C>T	uc002ixi.2	+	1	1357	c.1315C>T	c.(1315-1317)CAT>TAT	p.H439Y		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	439					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					ACAGCCTTCCCATTTTGAACT	0.478													16	38					0	0	0	0	T	57288727	T	T	57288727	3	4	287	1	0	0	0	0	1	0	0	0	1885	594	21	4	1317	4	C17orf71	17	57288727	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	5386682	57288727	23906483	87	53419											
ITGB4	3691	broad.mit.edu	37	chr17	73748588	73748588	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggggaggactacgacagcttCcttatgtacagcgatgacgt	10	9	13	9	3	0	1	0	1	0	0	1	5	1	3	1	3	4	2	1	3	3	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr17:73748588C>T	uc002jpg.2	+	32	4225	c.4038C>T	c.(4036-4038)TTC>TTT	p.F1346F	ITGB4_uc002jph.2_Silent_p.F1346F|ITGB4_uc002jpi.3_Silent_p.F1346F|ITGB4_uc002jpj.2_Silent_p.F1346F|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1346	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACGACAGCTTCCTTATGTACA	0.627													15	79					0	0	0	0	T	73748588	T	T	73748588	2	4	287	1	0	0	0	0	0	0	0	1	7936	854	30	2		2	ITGB4	17	73748588	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	16459861	73748588	7446622	88	53420											
WDR7	23335	broad.mit.edu	37	chr18	54424102	54424102	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatcaaggaacacctccttGatgatgaagaggaggatgag	15	7	12	7	0	1	5	1	4	0	1	2	8	2	8	2	3	1	0	2	3	3	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr18:54424102G>C	uc002lgk.1	+	15	2489	c.2278G>C	c.(2278-2280)GAT>CAT	p.D760H	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.D760H	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	760										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		ACACCTCCTTGATGATGAAGA	0.423													7	25					0	0	0	0	C	54424102	C	C	54424102	3	2	287	1	0	0	0	0	1	0	0	0	17388	1290	45	2	2332	2	WDR7	18	54424102	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08		54424102	23653146	89	53421											
CDH19	28513	broad.mit.edu	37	chr18	64176256	64176256	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgatcataatgcaaatgaGaatagcaatgatgacttctg	16	12	8	5	0	2	4	1	4	1	1	2	5	2	4	0	0	2	2	0	0	6	4	rs150398178	byFrequency	TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr18:64176256G>A	uc002lkc.1	-	11	1942	c.1804C>T	c.(1804-1806)CTC>TTC	p.L602F	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Intron	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	602	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				ATGCAAATGAGAATAGCAATG	0.418													17	58					0	0	0	0	A	64176256	A	A	64176256	3	1	287	1	0	0	0	0	1	0	0	0	3119	942	33	2	522	2	CDH19	18	64176256	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	9752154	64176256	13900992	90	53422											
MUC16	94025	broad.mit.edu	37	chr19	9060890	9060890	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagacaccagggaagatggAgggctagttttttccactga	13	9	12	7	0	0	3	0	1	0	2	1	5	1	5	2	3	0	2	2	3	3	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr19:9060890A>G	uc002mkp.2	-	3	26760	c.26556T>C	c.(26554-26556)CCT>CCC	p.P8852P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8854	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGAAGATGGAGGGCTAGTTT	0.522													26	113					0	0	0	0	G	9060890	G	G	9060890	2	3	287	1	0	0	0	0	0	0	0	1	10026	291	11	5		5	MUC16	19	9060890	Silent	SNP	A	TCGA-DQ-5631-01A-01D-1870-08		9060890	50068093	91	53423											
TSSK6	83983	broad.mit.edu	37	chr19	19625929	19625929	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctccggggatgcgcccgttgCgctgcacggcttgcagcagg	4	7	16	14	5	0	0	0	0	0	0	1	1	1	1	2	4	5	6	2	4	0	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr19:19625929C>T	uc002nmr.2	-	1	541	c.308G>A	c.(307-309)CGC>CAC	p.R103H	TSSK6_uc002nmq.2_RNA|NDUFA13_uc002nms.2_5'Flank|NDUFA13_uc010xqx.1_5'Flank|NDUFA13_uc010xqy.1_5'Flank	NM_032037	NP_114426	Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6	103	Protein kinase.				multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1						GCGCCCGTTGCGCTGCACGGC	0.652													17	53					0	0	0	0	T	19625929	T	T	19625929	3	4	287	1	0	0	0	0	1	0	0	0	16739	768	27	1	517	1	TSSK6	19	19625929	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	10565039	19625929	39503054	92	53424											
WDR88	126248	broad.mit.edu	37	chr19	33647373	33647373	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acgtccacacaggggagtttCgaaactgtggagcctgtgtg	9	9	14	9	2	0	0	0	0	0	0	2	3	1	2	2	3	2	1	2	3	1	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr19:33647373C>T	uc002nui.2	+	7	1000	c.922C>T	c.(922-924)CGA>TGA	p.R308*		NM_173479	NP_775750	Q6ZMY6	WDR88_HUMAN	PQQ repeat and WD repeat domain containing	308	WD 5.									ovary(1)|breast(1)|central_nervous_system(1)	3	Esophageal squamous(110;0.137)					AGGGGAGTTTCGAAACTGTGG	0.463													24	68					0	0	0	0	T	33647373	T	T	33647373	4	4	287	1	0	0	0	0	0	1	0	0	17403	876	31	1	948	1	WDR88	19	33647373	Nonsense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	14021444	33647373	25481610	93	53425											
HNRNPL	3191	broad.mit.edu	37	chr19	39327374	39327374	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcacctaattaggaggcgtgCtgagcagtggagaaacacaa	14	6	13	8	1	0	2	0	1	0	1	0	4	0	3	1	3	3	3	1	3	4	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr19:39327374C>A	uc010xul.1	-	13	1769	c.1758G>T	c.(1756-1758)CAG>CAT	p.Q586H	HNRNPL_uc010ege.1_Intron|HNRNPL_uc002ojj.1_Intron|HNRNPL_uc002ojo.1_3'UTR|HNRNPL_uc002ojk.2_Missense_Mutation_p.Q242H|HNRNPL_uc002ojl.2_Missense_Mutation_p.Q242H|HNRNPL_uc010xum.1_Missense_Mutation_p.Q453H	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	586					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			AGGAGGCGTGCTGAGCAGTGG	0.453													4	162					0.00909568	0.00965114	1	0	A	39327374	A	A	39327374	3	1	287	1	0	0	0	0	1	0	0	0	7309	796	28	4	15	4	HNRNPL	19	39327374	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	5680001	39327374	19801609	94	53426											
AP2A1	160	broad.mit.edu	37	chr19	50309485	50309485	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcaggtgggctgtctgcttcGgctggagcccaatgcccagg	5	8	16	12	1	1	0	0	0	1	0	2	1	1	1	2	5	3	4	2	5	1	1			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr19:50309485G>A	uc002ppn.2	+	23	3042	c.2831G>A	c.(2830-2832)CGG>CAG	p.R944Q	AP2A1_uc002ppo.2_Missense_Mutation_p.R922Q|AP2A1_uc010enk.2_Missense_Mutation_p.R75Q	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	944				ENFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRTSKEP VSRHLCELLAQQF -> GDREDTRVWGMPGTFLRPFVFLFL FICCCLHSGGLGGVPLPPFPPQAQRGEGPGKWMSPPLPPHP VVAPPTPSPSRGCVLL (in Ref. 4; AAH14214).	axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		TGTCTGCTTCGGCTGGAGCCC	0.637													6	11					0	0	0	0	A	50309485	A	A	50309485	3	1	287	1	0	0	0	0	1	0	0	0	739	1116	39	1	2921	1	AP2A1	19	50309485	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	10982111	50309485	8819498	95	53427											
SIGLEC6	946	broad.mit.edu	37	chr19	52034681	52034681	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cgaggctggaagggtagtggGcaatctgcagggtacgagga	10	6	19	6	2	1	0	0	0	1	0	1	4	1	2	0	6	2	5	0	6	4	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr19:52034681G>A	uc002pwy.2	-	2	322	c.160C>T	c.(160-162)CCC>TCC	p.P54S	SIGLEC6_uc002pwz.2_Missense_Mutation_p.P54S|SIGLEC6_uc002pxa.2_Missense_Mutation_p.P54S|SIGLEC6_uc010ydb.1_Intron|SIGLEC6_uc010ydc.1_Missense_Mutation_p.P43S|SIGLEC6_uc010eoz.1_Missense_Mutation_p.P43S|SIGLEC6_uc010epb.1_Intron|SIGLEC6_uc010epa.1_Missense_Mutation_p.P43S	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	54	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		AGGGTAGTGGGCAATCTGCAG	0.597													13	54					0	0	0	0	A	52034681	A	A	52034681	3	1	287	1	0	0	0	0	1	0	0	0	14377	1203	42	4	1262	4	SIGLEC6	19	52034681	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	1725196	52034681	7094302	96	53428											
ZNF761	388561	broad.mit.edu	37	chr19	53959369	53959369	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acctttagttggaagtcatcCcttacctgccatcgtagact	9	13	7	12	1	1	1	1	0	0	1	3	2	2	2	4	1	2	2	4	1	4	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr19:53959369C>T	uc010eqp.2	+	7	2066	c.1608C>T	c.(1606-1608)TCC>TCT	p.S536S	ZNF761_uc010ydy.1_Silent_p.S482S|ZNF761_uc002qbt.1_Silent_p.S482S	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	536	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		GGAAGTCATCCCTTACCTGCC	0.443													21	82					0	0	0	0	T	53959369	T	T	53959369	2	4	287	1	0	0	0	0	0	0	0	1	18203	610	22	4		4	ZNF761	19	53959369	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	1924688	53959369	5169614	97	53429											
CACNG8	59283	broad.mit.edu	37	chr19	54466508	54466508	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcggcctcatgaccatcGccatcagcactgactactgg	8	9	8	16	2	2	2	2	2	0	0	4	2	2	2	4	2	2	1	4	2	1	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr19:54466508G>A	uc002qcs.1	+	1	215	c.109G>A	c.(109-111)GCC>ACC	p.A37T		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	38	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		CATGACCATCGCCATCAGCAC	0.697													6	16					0	0	0	0	A	54466508	A	A	54466508	3	1	287	1	0	0	0	0	1	0	0	0	2575	1087	38	1	114	1	CACNG8	19	54466508	Missense_Mutation	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	507139	54466508	4662475	98	53430											
LILRA1	11024	broad.mit.edu	37	chr19	55106777	55106777	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggccccgtgagcccgagtCgcaggtggtcgtacaggtgc	5	7	17	12	4	0	1	0	1	0	0	2	2	0	1	3	4	3	2	3	4	1	1	rs141328341		TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr19:55106777C>T	uc002qgh.1	+	5	753	c.571C>T	c.(571-573)CGC>TGC	p.R191C	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.R191C	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	191	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GAGCCCGAGTCGCAGGTGGTC	0.567													60	159					0	0	0	0	T	55106777	T	T	55106777	3	4	287	1	0	0	0	0	1	0	0	0	8825	884	31	1	585	1	LILRA1	19	55106777	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	640269	55106777	4022206	99	53431											
NLRP7	199713	broad.mit.edu	37	chr19	55450945	55450945	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcgcggccaggaggctcagCgtccgcagcgcgccccgcag	5	3	16	17	7	1	0	1	0	0	0	2	1	2	1	4	3	3	3	4	3	0	0			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr19:55450945C>T	uc002qih.3	-	4	1318	c.1242G>A	c.(1240-1242)ACG>ACA	p.T414T	NLRP7_uc002qig.3_Silent_p.T414T|NLRP7_uc002qii.3_Silent_p.T414T|NLRP7_uc010esk.2_Silent_p.T414T|NLRP7_uc010esl.2_Silent_p.T442T	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	414	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GGAGGCTCAGCGTCCGCAGCG	0.711													5	31					0	0	0	0	T	55450945	T	T	55450945	2	4	287	1	0	0	0	0	0	0	0	1	10536	755	27	1		1	NLRP7	19	55450945	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	344168	55450945	3678038	100	53432											
DEFB124	245937	broad.mit.edu	37	chr20	30053437	30053437	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agtttggcaggccccttgacCcttccagcaccgtttgaatt	7	12	9	13	1	0	2	0	2	0	0	1	2	1	2	5	2	1	4	5	2	1	5			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr20:30053437C>T	uc002wvz.1	-	2	88	c.88G>A	c.(88-90)GGT>AGT	p.G30S		NM_001037500	NP_001032589	Q8NES8	DB124_HUMAN	beta-defensin 124 precursor	30					defense response to bacterium	extracellular region					0	Lung NSC(7;0.000139)|all_lung(7;0.000197)|all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GCCCCTTGACCCTTCCAGCAC	0.522													39	141					0	0	0	0	T	30053437	T	T	30053437	3	4	287	1	0	0	0	0	1	0	0	0	4431	623	22	4	131	4	DEFB124	20	30053437	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08		30053437	32972083	101	53433											
ASXL1	171023	broad.mit.edu	37	chr20	31021696	31021696	+	Frame_Shift_Del	DEL	G	-	-																															aagccacagcccactaaagaGgagcccaaagtcccgcccat																										TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr20:31021696delG	uc002wxs.2	+	11	2121	c.1695delG	c.(1693-1695)GAGfs	p.E565fs	ASXL1_uc010geb.2_Frame_Shift_Del_p.E456fs	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	565					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CCACTAAAGAGGAGCCCAAAG	0.512			F|N|Mis		MDS|CMML								---	---	---								-	31021696	-	-	31021696	7	5	287	1	0	1	0	1	0	0	0	0	1068	991	35	0	1747	0	ASXL1	20	31021696	Frame_Shift_Del	DEL	G	TCGA-DQ-5631-01A-01D-1870-08	968259	31021696	32003824	102	53434											
SLC12A5	57468	broad.mit.edu	37	chr20	44680470	44680470	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggctggccccgcaactggCgccagaaggaagatcatcag	10	6	13	12	2	2	2	2	0	0	2	2	3	2	3	3	4	1	2	3	4	3	1	rs149667115		TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr20:44680470C>T	uc010zxl.1	+	18	2483	c.2407C>T	c.(2407-2409)CGC>TGC	p.R803C	SLC12A5_uc002xrb.2_Missense_Mutation_p.R780C	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	803					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCGCAACTGGCGCCAGAAGGA	0.622													45	92					0	0	0	0	T	44680470	T	T	44680470	3	4	287	1	0	0	0	0	1	0	0	0	14451	768	27	1	2533	1	SLC12A5	20	44680470	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	13658774	44680470	18345050	103	53435											
OGFR	11054	broad.mit.edu	37	chr20	61444556	61444556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccccagcccagcaggacctgCaggggacgagccagccgaga	10	1	14	16	2	0	1	0	0	0	1	0	5	0	3	6	3	5	2	6	3	0	0			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr20:61444556C>T	uc002ydj.2	+	7	1624	c.1589C>T	c.(1588-1590)GCA>GTA	p.A530V	OGFR_uc002ydk.2_Missense_Mutation_p.A513V|OGFR_uc002ydl.2_Missense_Mutation_p.A478V|uc011aam.1_Silent_p.L29L	NM_007346	NP_031372	Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	530	1.|7 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]- [GR]-D-E-P-A-[EK].				regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity				0	Breast(26;3.65e-08)					GCAGGACCTGCAGGGGACGAG	0.701													4	15					0	0	0	0	T	61444556	T	T	61444556	3	4	287	1	0	0	0	0	1	0	0	0	10897	710	25	4	1615	4	OGFR	20	61444556	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	16764086	61444556	1580964	104	53436											
ADAMTS5	11096	broad.mit.edu	37	chr21	28338153	28338153	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagacgtgcaggatccgtgcGgacccatccccgtacacgcg	8	6	12	15	6	0	1	0	0	0	1	2	3	2	3	4	2	3	2	4	2	2	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chr21:28338153G>A	uc002ymg.2	-	1	1287	c.558C>T	c.(556-558)TCC>TCT	p.S186S		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	186					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GGATCCGTGCGGACCCATCCC	0.697													5	19					0	0	0	0	A	28338153	A	A	28338153	2	1	287	1	0	0	0	0	0	0	0	1	269	1103	39	1		1	ADAMTS5	21	28338153	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08		28338153	19791742	105	53437											
ARSF	416	broad.mit.edu	37	chrX	2998964	2998964	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtaatagacgtgtcatcCaaaatcttgcagtccccgca	11	10	9	11	2	2	1	1	0	1	1	4	1	4	1	3	1	1	3	3	1	4	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chrX:2998964C>T	uc004cre.1	+	5	537	c.316C>T	c.(316-318)CAA>TAA	p.Q106*	ARSF_uc004crf.1_Nonsense_Mutation_p.Q106*	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	106						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACGTGTCATCCAAAATCTTGC	0.413													21	12					0	0	0	0	T	2998964	T	T	2998964	4	4	287	1	0	0	0	0	0	1	0	0	993	595	21	4	330	4	ARSF	23	2998964	Nonsense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08		2998964	152271596	106	53438											
PRKX	5613	broad.mit.edu	37	chrX	3573309	3573309	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctttggagtgcaggtactcGatggcacagatgatctctgc	8	12	12	9	1	2	2	0	1	2	1	4	4	2	3	0	3	3	3	0	3	1	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chrX:3573309G>A	uc010nde.2	-	3	847	c.480C>T	c.(478-480)ATC>ATT	p.I160I		NM_005044	NP_005035	P51817	PRKX_HUMAN	protein kinase, X-linked	160	Protein kinase.						ATP binding|cAMP-dependent protein kinase activity			skin(2)|lung(1)	3		all_lung(23;0.000396)|Lung NSC(23;0.00123)				GCAGGTACTCGATGGCACAGA	0.577													35	49					0	0	0	0	A	3573309	A	A	3573309	2	1	287	1	0	0	0	0	0	0	0	1	12589	1048	37	1		1	PRKX	23	3573309	Silent	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	574345	3573309	151697251	107	53439											
CTPS2	56474	broad.mit.edu	37	chrX	16635319	16635319	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctccatcaacatcctgaccTacaaaacttaagtcattctg	13	12	3	13	0	4	1	2	1	2	0	6	1	5	1	3	0	3	0	3	0	5	3			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chrX:16635319T>C	uc004cxk.2	-	16	2244	c.1500A>G	c.(1498-1500)GTA>GTG	p.V500V	CTPS2_uc004cxl.2_Silent_p.V500V|CTPS2_uc004cxm.2_Silent_p.V500V	NM_001144002	NP_001137474	Q9NRF8	PYRG2_HUMAN	cytidine triphosphate synthase II	500	Glutamine amidotransferase type-1.				glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)					CATCCTGACCTACAAAACTTA	0.398													3	114					0	0	0	0	C	16635319	C	C	16635319	2	2	287	1	0	0	0	0	0	0	0	1	4040	1509	53	5		5	CTPS2	23	16635319	Silent	SNP	T	TCGA-DQ-5631-01A-01D-1870-08	13062010	16635319	138635241	108	53440											
MAP7D2	256714	broad.mit.edu	37	chrX	20082895	20082895	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctttggccaatctctgcctCtcatctgatttcaaaaatcc	9	15	4	13	0	5	1	2	1	4	0	8	1	6	1	3	1	1	0	3	1	3	2			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chrX:20082895C>T	uc004czr.1	-	2	178	c.159G>A	c.(157-159)GAG>GAA	p.E53E	MAP7D2_uc011mji.1_Silent_p.E9E|MAP7D2_uc010nfo.1_Silent_p.E53E|MAP7D2_uc011mjj.1_Silent_p.E53E|MAP7D2_uc004czs.1_Silent_p.E9E	NM_152780	NP_689993	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	53	Potential.									ovary(2)|breast(1)	3						ATCTCTGCCTCTCATCTGATT	0.408													8	20					0	0	0	0	T	20082895	T	T	20082895	2	4	287	1	0	0	0	0	0	0	0	1	9321	912	32	2		2	MAP7D2	23	20082895	Silent	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	3447576	20082895	135187665	109	53441											
BCOR	54880	broad.mit.edu	37	chrX	39934150	39934150	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgtattccaggcggtgttTtgtatatagcactgaagcca	9	15	10	7	1	0	1	0	1	0	0	1	1	1	1	2	2	2	4	2	2	5	8			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chrX:39934150T>C	uc004den.3	-	4	741	c.449A>G	c.(448-450)AAA>AGA	p.K150R	BCOR_uc004dep.3_Missense_Mutation_p.K150R|BCOR_uc004deo.3_Missense_Mutation_p.K150R|BCOR_uc004dem.3_Missense_Mutation_p.K150R|BCOR_uc004deq.3_Missense_Mutation_p.K150R	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	150					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						AGGCGGTGTTTTGTATATAGC	0.507													27	33					0	0	0	0	C	39934150	C	C	39934150	3	2	287	1	0	0	0	0	1	0	0	0	1388	1841	64	5	4866	5	BCOR	23	39934150	Missense_Mutation	SNP	T	TCGA-DQ-5631-01A-01D-1870-08	19851255	39934150	115336410	110	53442											
GAGE10	643832	broad.mit.edu	37	chrX	49158062	49158062	+	5'Flank	DEL	T	-	-																															gtatgcagagacatcattccTtttttttttttctttttttc																										TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chrX:49158062delT	uc010nir.1	+							NM_001098413	NP_001091883	A6NGK3	GAG10_HUMAN	G antigen 10												0	Ovarian(276;0.236)					acatcattccttttttttttt	0													---	---	---								-	49158062	-	-	49158062	6	5	287	0	1	1	0	1	0	0	0	0	6221	1624	56	0		0	GAGE10	23	49158062	5'Flank	DEL	T	TCGA-DQ-5631-01A-01D-1870-08	9223912	49158062	106112498	111	53443											
PCDH11X	27328	broad.mit.edu	37	chrX	91090676	91090676	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattccaaacaagtccttgaCaactgctatgcagttcaagc	13	10	7	11	0	1	1	1	1	0	0	3	2	3	1	2	0	5	3	2	0	5	4			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chrX:91090676C>A	uc004efk.1	+	1	1018	c.173C>A	c.(172-174)ACA>AAA	p.T58K	PCDH11X_uc004efl.1_Missense_Mutation_p.T58K|PCDH11X_uc004efo.1_Missense_Mutation_p.T58K|PCDH11X_uc010nmv.1_Missense_Mutation_p.T58K|PCDH11X_uc004efm.1_Missense_Mutation_p.T58K|PCDH11X_uc004efn.1_Missense_Mutation_p.T58K|PCDH11X_uc004efh.1_Missense_Mutation_p.T58K|PCDH11X_uc004efj.1_Missense_Mutation_p.T58K	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	58	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						AAGTCCTTGACAACTGCTATG	0.453													36	68					9.04072e-19	1.05602e-18	1	0	A	91090676	A	A	91090676	3	1	287	1	0	0	0	0	1	0	0	0	11562	478	17	4	175	4	PCDH11X	23	91090676	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	41932614	91090676	64179884	112	53444											
CXorf48	54967	broad.mit.edu	37	chrX	134305034	134305034	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgctgctgtgggccctgtCgctctgcagggtcggccgtc	1	10	15	15	3	1	0	0	0	1	0	4	0	1	0	3	3	3	4	3	3	0	0			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chrX:134305034C>T	uc004eyk.1	-	1	718	c.62G>A	c.(61-63)CGA>CAA	p.R21Q	CXorf48_uc004eyl.1_Missense_Mutation_p.R21Q	NM_001031705	NP_001026875	Q8WUE5	CX048_HUMAN	hypothetical protein LOC54967 isoform 1	21											0	Acute lymphoblastic leukemia(192;0.000127)					TGGGCCCTGTCGCTCTGCAGG	0.642													19	55					0	0	0	0	T	134305034	T	T	134305034	3	4	287	1	0	0	0	0	1	0	0	0	4128	884	31	1	760	1	CXorf48	23	134305034	Missense_Mutation	SNP	C	TCGA-DQ-5631-01A-01D-1870-08	43214358	134305034	20965526	113	53445											
MAGEA12	4111	broad.mit.edu	37	chrX	151896274	151896274	+	RNA	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaggtttttttgaagcggcGgtcttttagggagagccttt	6	16	13	6	2	2	2	1	1	1	1	2	3	2	2	1	4	2	1	1	4	2	6			TCGA-DQ-5631-01A-01D-1870-08	TCGA-DQ-5631-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	e389975a-e588-48d4-9ed3-548e8ed9de1c	c919d822-b6c9-48d0-b570-0b7b127592f4	g.chrX:151896274G>A	uc004fgb.2	-	4		c.493C>T						P43365	MAGAC_HUMAN	Homo sapiens melanoma antigen family A, 12, mRNA (cDNA clone MGC:4914 IMAGE:3450217), complete cds.											skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TTGAAGCGGCGGTCTTTTAGG	0.502													76	63					0	0	0	0	A	151896274	A	A	151896274	1	1	287	0	1	0	0	0	0	0	0	0	9217	1131	39	1		1	MAGEA12	23	151896274	RNA	SNP	G	TCGA-DQ-5631-01A-01D-1870-08	17591240	151896274	3374286	114	53446											
MTOR	2475	broad.mit.edu	37	chr1	11186691	11186691	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtccttacccataagtgtcaAtttccggggcctctgcttgg	6	13	10	12	1	2	0	1	0	1	0	4	0	4	0	4	3	2	1	4	3	3	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:11186691A>T	uc001asd.2	-	46	6635	c.6514T>A	c.(6514-6516)TTG>ATG	p.L2172M	MTOR_uc001asc.2_Missense_Mutation_p.L377M	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	2172					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						ATAAGTGTCAATTTCCGGGGC	0.512													20	29					0	0	0	0	T	11186691	T	T	11186691	3	4	288	1	0	0	0	0	1	0	0	0	10007	98	4	5	1187	5	MTOR	1	11186691	Missense_Mutation	SNP	A	TCGA-DQ-7588-01A-11D-2078-08		11186691	238063930	1	53447											
LOC440563	440563	broad.mit.edu	37	chr1	13183335	13183335	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcctgcttaatggcctgaaGgtcatctcctttcagctttc	6	15	7	13	0	3	1	2	1	1	0	6	1	4	1	3	2	2	2	3	2	2	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:13183335G>T	uc010obg.1	-	1	633	c.538C>A	c.(538-540)CTT>ATT	p.L180I		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	180						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						ATGGCCTGAAGGTCATCTCCT	0.453													88	403					4.78148e-37	5.61133e-37	1	0	T	13183335	T	T	13183335	3	4	288	1	0	0	0	0	1	0	0	0	8928	1000	35	4	347	4	LOC440563	1	13183335	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	1996644	13183335	236067286	2	53448											
EPHB2	2048	broad.mit.edu	37	chr1	23235659	23235659	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctactgggacatgaccaacCaggatgtaagtctccaaggg	12	7	11	11	0	1	1	0	1	1	0	2	3	1	3	4	3	2	1	4	3	4	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:23235659C>T	uc009vqj.1	+	13	2642	c.2497C>T	c.(2497-2499)CAG>TAG	p.Q833*	EPHB2_uc001bge.2_Nonsense_Mutation_p.Q834*|EPHB2_uc001bgf.2_Nonsense_Mutation_p.Q833*|EPHB2_uc010odu.1_Nonsense_Mutation_p.Q775*	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	833	Cytoplasmic (Potential).|Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CATGACCAACCAGGATGTAAG	0.592									Hereditary_Prostate_Cancer				15	37					0	0	0	0	T	23235659	T	T	23235659	4	4	288	1	0	0	0	0	0	1	0	0	5199	595	21	4	2550	4	EPHB2	1	23235659	Nonsense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	10052324	23235659	226014962	3	53449											
ELAVL4	1996	broad.mit.edu	37	chr1	50642774	50642774	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tccacaggacagagtttaggGtatggatttgttaactatat	12	14	10	5	0	0	1	0	0	0	1	1	3	1	3	1	3	1	3	1	3	5	7			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:50642774G>T	uc001csb.2	+	3	532	c.264G>T	c.(262-264)GGG>GGT	p.G88G	ELAVL4_uc001cry.3_Silent_p.G91G|ELAVL4_uc001crz.3_Silent_p.G88G|ELAVL4_uc001csa.3_Silent_p.G105G|ELAVL4_uc001csc.3_Silent_p.G88G|ELAVL4_uc009vyu.2_Silent_p.G93G|ELAVL4_uc010omz.1_Silent_p.G93G	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	88	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						AGAGTTTAGGGTATGGATTTG	0.274													16	29					6.31663e-08	6.74407e-08	1	0	T	50642774	T	T	50642774	2	4	288	1	0	0	0	0	0	0	0	1	5076	1248	44	4		4	ELAVL4	1	50642774	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	27407115	50642774	198607847	4	53450											
DOCK7	85440	broad.mit.edu	37	chr1	63005526	63005526	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttccttggagcctcaagtTtatcattaaagtataaatgg	12	16	7	6	0	2	0	2	0	0	0	3	1	3	1	2	2	1	2	2	2	7	8			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:63005526T>A	uc001daq.2	-	26	3117	c.3083A>T	c.(3082-3084)AAA>ATA	p.K1028I	DOCK7_uc001dan.2_Missense_Mutation_p.K889I|DOCK7_uc001dao.2_Missense_Mutation_p.K889I|DOCK7_uc001dap.2_Missense_Mutation_p.K997I|DOCK7_uc001dam.2_Missense_Mutation_p.K208I	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1028					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AGCCTCAAGTTTATCATTAAA	0.328													10	17					0	0	0	0	A	63005526	A	A	63005526	3	1	288	1	0	0	0	0	1	0	0	0	4714	1841	64	5	3439	5	DOCK7	1	63005526	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	12362752	63005526	186245095	5	53451											
GBP1	2633	broad.mit.edu	37	chr1	89521862	89521862	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgagcaacgatctgatgatGcttcctgattctgtttacaa	10	14	8	9	1	2	4	0	4	2	0	3	5	3	4	1	0	4	3	1	0	3	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:89521862G>A	uc001dmx.2	-	8	1425	c.1205C>T	c.(1204-1206)GCA>GTA	p.A402V		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	402					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		ATCTGATGATGCTTCCTGATT	0.413													48	98					0	0	0	0	A	89521862	A	A	89521862	3	1	288	1	0	0	0	0	1	0	0	0	6308	1319	46	4	589	4	GBP1	1	89521862	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	26516336	89521862	159728759	6	53452											
SV2A	9900	broad.mit.edu	37	chr1	149880767	149880767	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgacatggtgaaccacacAcccatcatcatcagagtgat	15	8	7	11	0	3	4	3	3	0	1	3	4	3	4	2	1	1	0	2	1	2	0			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:149880767A>T	uc001etg.2	-	8	1847	c.1356T>A	c.(1354-1356)GGT>GGA	p.G452G	SV2A_uc009wlk.2_5'Flank|SV2A_uc001eth.2_Silent_p.G452G	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	452	Helical; (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	TGAACCACACACCCATCATCA	0.532													29	41					0	0	0	0	T	149880767	T	T	149880767	2	4	288	1	0	0	0	0	0	0	0	1	15483	146	6	5		5	SV2A	1	149880767	Silent	SNP	A	TCGA-DQ-7588-01A-11D-2078-08	60358905	149880767	99369854	7	53453											
COPA	1314	broad.mit.edu	37	chr1	160267363	160267363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caccaatcttcatcatcttgCgaagtttttctaagttgcca	10	15	5	11	1	5	0	2	0	3	0	5	1	5	0	2	0	2	2	2	0	3	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:160267363C>T	uc009wti.2	-	20	2544	c.2150G>A	c.(2149-2151)CGC>CAC	p.R717H	COPA_uc001fvv.3_Missense_Mutation_p.R726H	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	717					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATCATCTTGCGAAGTTTTTC	0.438													26	66					0	0	0	0	T	160267363	T	T	160267363	3	4	288	1	0	0	0	0	1	0	0	0	3742	768	27	1	1580	1	COPA	1	160267363	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	10386596	160267363	88983258	8	53454											
PTPRC	5788	broad.mit.edu	37	chr1	198713186	198713186	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcttgaaattgtaggccCagtacatcttgatccatcag	10	14	8	9	0	3	2	1	2	2	0	4	2	4	2	2	1	1	3	2	1	3	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:198713186C>T	uc001gur.1	+	26	2875	c.2695C>T	c.(2695-2697)CAG>TAG	p.Q899*	PTPRC_uc001gus.1_Nonsense_Mutation_p.Q851*|PTPRC_uc001gut.1_Nonsense_Mutation_p.Q738*	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	899	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ATTGTAGGCCCAGTACATCTT	0.328													6	25					0	0	0	0	T	198713186	T	T	198713186	4	4	288	1	0	0	0	0	0	1	0	0	12862	595	21	4	2804	4	PTPRC	1	198713186	Nonsense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	38445823	198713186	50537435	9	53455											
KLHL12	59349	broad.mit.edu	37	chr1	202887508	202887508	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taagaactcacagcaggcttGtttcacacctaggacagaca	14	8	8	11	0	2	2	2	0	0	2	2	3	2	3	1	2	2	3	1	2	3	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:202887508G>T	uc001gyo.1	-	4	558	c.358C>A	c.(358-360)CAA>AAA	p.Q120K	KLHL12_uc001gyn.1_5'UTR|KLHL12_uc010pqc.1_Missense_Mutation_p.Q158K|KLHL12_uc009xah.1_Missense_Mutation_p.Q120K	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	120					Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			CAGCAGGCTTGTTTCACACCT	0.428													26	34					3.08376e-08	3.3427e-08	1	0	T	202887508	T	T	202887508	3	4	288	1	0	0	0	0	1	0	0	0	8407	1386	48	4	1384	4	KLHL12	1	202887508	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	4174322	202887508	46363113	10	53456											
KLHDC8A	55220	broad.mit.edu	37	chr1	205308854	205308854	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctagggacacccacatGtccttcagcatgtcatagtg	9	10	11	11	0	2	0	2	0	0	0	3	1	3	1	2	2	2	2	2	2	2	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:205308854G>T	uc001hcf.1	-	3	1027	c.459C>A	c.(457-459)GAC>GAA	p.D153E	KLHDC8A_uc010prg.1_Missense_Mutation_p.D40E|KLHDC8A_uc001hcg.1_Missense_Mutation_p.D153E	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	153	Kelch 4.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACACCCACATGTCCTTCAGCA	0.552													9	28					3.09899e-07	3.284e-07	1	0	T	205308854	T	T	205308854	3	4	288	1	0	0	0	0	1	0	0	0	8401	1368	48	4	609	4	KLHDC8A	1	205308854	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	2421346	205308854	43941767	11	53457											
PTPN14	5784	broad.mit.edu	37	chr1	214585062	214585062	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atactctctgaggaaatcttGagaatcaaactgattatagt	15	13	7	6	0	3	3	1	3	2	1	4	5	3	4	0	1	2	0	0	1	6	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:214585062G>A	uc001hkk.1	-	5	746	c.475C>T	c.(475-477)CAA>TAA	p.Q159*	PTPN14_uc010pty.1_Nonsense_Mutation_p.Q60*	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	159	FERM.		Q -> E (in a breast cancer sample; somatic mutation).		lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding	p.Q159E(1)		breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		AGGAAATCTTGAGAATCAAAC	0.303													14	25					0	0	0	0	A	214585062	A	A	214585062	4	1	288	1	0	0	0	0	0	1	0	0	12846	1299	45	2	3148	2	PTPN14	1	214585062	Nonsense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	9276208	214585062	34665559	12	53458											
MIA3	375056	broad.mit.edu	37	chr1	222803326	222803326	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcatagtgacaagagggagGacttacttatcataagcagc	14	8	12	7	0	1	2	1	1	0	1	1	4	1	4	0	3	3	2	0	3	5	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:222803326G>C	uc001hnl.2	+	4	2773	c.2764G>C	c.(2764-2766)GAC>CAC	p.D922H	MIA3_uc009xea.1_Missense_Mutation_p.D758H	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	922	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		CAAGAGGGAGGACTTACTTAT	0.468													6	49					0	0	0	0	C	222803326	C	C	222803326	3	2	288	1	0	0	0	0	1	0	0	0	9618	1174	41	2	2778	2	MIA3	1	222803326	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	8218264	222803326	26447295	13	53459											
OR2W3	343171	broad.mit.edu	37	chr1	248059405	248059405	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccccgctgtgggcaccacGaggtggaccacttcctgcgt	6	8	12	15	3	0	0	0	0	0	0	1	2	1	1	5	3	2	2	5	3	1	2	rs139271211		TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr1:248059405G>T	uc001idp.1	+	3	786	c.517G>T	c.(517-519)GAG>TAG	p.E173*	OR2W3_uc010pzb.1_Nonsense_Mutation_p.E173*	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGGGCACCACGAGGTGGACCA	0.657													27	33					2.36697e-06	2.4714e-06	1	0	T	248059405	T	T	248059405	4	4	288	1	0	0	0	0	0	1	0	0	11087	1059	37	3	519	3	OR2W3	1	248059405	Nonsense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	25256079	248059405	1191216	14	53460											
NRBP1	29959	broad.mit.edu	37	chr2	27662654	27662654	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agttcattcaaaagtgcctgCagtctgagcctgctcgcaga	10	10	10	11	1	3	2	2	1	1	1	4	2	3	2	2	0	4	4	2	0	2	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:27662654C>T	uc002rko.2	+	12	1757	c.925C>T	c.(925-927)CAG>TAG	p.Q309*	NRBP1_uc002rkq.2_Nonsense_Mutation_p.Q308*|NRBP1_uc002rkp.2_Nonsense_Mutation_p.Q309*|NRBP1_uc002rkr.2_Nonsense_Mutation_p.Q100*|KRTCAP3_uc002rks.2_5'Flank|KRTCAP3_uc010ylr.1_5'Flank|KRTCAP3_uc002rkt.2_5'Flank	NM_013392	NP_037524	Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein	309	Protein kinase.				ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			ovary(2)|lung(1)	3	Acute lymphoblastic leukemia(172;0.155)					AAAGTGCCTGCAGTCTGAGCC	0.458													18	133					0	0	0	0	T	27662654	T	T	27662654	4	4	288	1	0	0	0	0	0	1	0	0	10696	711	25	4	963	4	NRBP1	2	27662654	Nonsense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08		27662654	215536719	15	53461											
ABCG8	64241	broad.mit.edu	37	chr2	44104782	44104782	+	Nonsense_Mutation	SNP	T	A	A																															cagttcagcagaagaacttaTaaaatgcctctcgggaacct																								rs147582834	byFrequency	TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:44104782T>A	uc002rtq.2	+	12	1929	c.1839T>A	c.(1837-1839)TAT>TAA	p.Y613*	ABCG8_uc010yoa.1_Nonsense_Mutation_p.Y612*	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	613	ABC transmembrane type-2.|Extracellular (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GAAGAACTTATAAAATGCCTC	0.522											OREG0014582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	33					0	0	0	0	A	44104782	A	A	44104782	4	1	288	1	0	0	0	0	0	1	0	0	72	1413	49	5	1885	5	ABCG8	2	44104782	Nonsense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	16442128	44104782	199094591	16	53462	122	2									
ABCG8	64241	broad.mit.edu	37	chr2	44104784	44104784	+	Missense_Mutation	SNP	A	T	T																															gttcagcagaagaacttataAaatgcctctcgggaacctca																										TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:44104784A>T	uc002rtq.2	+	12	1931	c.1841A>T	c.(1840-1842)AAA>ATA	p.K614I	ABCG8_uc010yoa.1_Missense_Mutation_p.K613I	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	614	ABC transmembrane type-2.|Extracellular (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGAACTTATAAAATGCCTCTC	0.517											OREG0014582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	32					0	0	0	0	T	44104784	T	T	44104784	3	4	288	1	0	0	0	0	1	0	0	0	72	14	1	5	1887	5	ABCG8	2	44104784	Missense_Mutation	SNP	A	TCGA-DQ-7588-01A-11D-2078-08	2	44104784	199094589	17	53463	122	2									
EGR4	1961	broad.mit.edu	37	chr2	73518918	73518918	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcaagcgaaggccttggcGtgcggccgcgggcagaagca	8	3	19	11	5	0	1	0	0	0	1	0	2	0	1	2	5	3	3	2	5	3	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:73518918G>A	uc010yrj.1	-	2	1512	c.1437C>T	c.(1435-1437)CAC>CAT	p.H479H	EGR4_uc010yrk.1_Silent_p.H478H	NM_001965	NP_001956	Q05215	EGR4_HUMAN	early growth response 4	375						intracellular	nucleic acid binding|zinc ion binding				0						AGGCCTTGGCGTGCGGCCGCG	0.716													5	14					0	0	0	0	A	73518918	A	A	73518918	2	1	288	1	0	0	0	0	0	0	0	1	4996	1136	40	1		1	EGR4	2	73518918	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	29414134	73518918	169680455	18	53464											
THSD7B	80731	broad.mit.edu	37	chr2	137814025	137814025	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtacaggagactgtggtcccGgaggagtccagagtcgggca	9	6	17	9	2	0	2	0	0	0	2	3	5	2	4	2	5	1	2	2	5	1	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:137814025G>A	uc002tva.1	+	2	82	c.82G>A	c.(82-84)GGA>AGA	p.G28R	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_5'UTR	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTGTGGTCCCGGAGGAGTCCA	0.493													16	30					0	0	0	0	A	137814025	A	A	137814025	3	1	288	1	0	0	0	0	1	0	0	0	15946	1117	39	1	88	1	THSD7B	2	137814025	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	64295107	137814025	105385348	19	53465											
RIF1	55183	broad.mit.edu	37	chr2	152311418	152311418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttgtttttagcaccacagaGaccttcagattggtccaaaa	12	13	7	9	0	1	2	1	0	0	2	2	3	2	2	3	1	1	2	3	1	3	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:152311418G>A	uc002txm.2	+	22	2484	c.2354G>A	c.(2353-2355)AGA>AAA	p.R785K	RIF1_uc002txl.2_Missense_Mutation_p.R785K|RIF1_uc010fnv.1_Missense_Mutation_p.R749K|RIF1_uc002txn.2_Missense_Mutation_p.R785K|RIF1_uc002txo.2_Missense_Mutation_p.R785K	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	785					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		GCACCACAGAGACCTTCAGAT	0.318													6	34					0	0	0	0	A	152311418	A	A	152311418	3	1	288	1	0	0	0	0	1	0	0	0	13424	942	33	2	2436	2	RIF1	2	152311418	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	14497393	152311418	90887955	20	53466											
PDE1A	5136	broad.mit.edu	37	chr2	183066183	183066183	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacctgcaggaaaaactcctCcattagggccatggtccacc	11	7	8	15	0	0	0	0	0	0	0	3	1	3	1	6	3	2	1	6	3	3	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:183066183C>T	uc002uos.2	-	11	1240	c.1156G>A	c.(1156-1158)GAG>AAG	p.E386K	PDE1A_uc010zfp.1_Missense_Mutation_p.E282K|PDE1A_uc002uoq.1_Missense_Mutation_p.E386K|PDE1A_uc010zfq.1_Missense_Mutation_p.E386K|PDE1A_uc002uor.2_Missense_Mutation_p.E370K|PDE1A_uc002uou.2_Missense_Mutation_p.E352K	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	386	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			AAAAACTCCTCCATTAGGGCC	0.483													35	40					0	0	0	0	T	183066183	T	T	183066183	3	4	288	1	0	0	0	0	1	0	0	0	11687	864	30	2	549	2	PDE1A	2	183066183	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	30754765	183066183	60133190	21	53467											
HECW2	57520	broad.mit.edu	37	chr2	197138837	197138837	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtcctgcatgtcgagaaTcttctcctacctgcaaacag	9	11	9	12	1	2	1	0	0	2	1	5	2	3	1	3	1	4	2	3	1	3	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:197138837T>A	uc002utm.1	-	16	3329	c.3146A>T	c.(3145-3147)GAT>GTT	p.D1049V	HECW2_uc002utl.1_Missense_Mutation_p.D693V	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1049	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						ATGTCGAGAATCTTCTCCTAC	0.438													14	15					0	0	0	0	A	197138837	A	A	197138837	3	1	288	1	0	0	0	0	1	0	0	0	7082	1435	50	5	1628	5	HECW2	2	197138837	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	14072654	197138837	46060536	22	53468											
ALS2CR8	79800	broad.mit.edu	37	chr2	203817391	203817391	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggggcaacttgtggatgtgaAtagtcctcggggtgagtaac	9	10	16	6	1	0	2	0	2	0	0	2	3	1	3	1	5	2	2	1	5	4	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:203817391A>G	uc002uzo.2	+	5	696	c.416A>G	c.(415-417)AAT>AGT	p.N139S	ALS2CR8_uc002uzn.2_Missense_Mutation_p.N37S|ALS2CR8_uc002uzm.2_Missense_Mutation_p.N139S|ALS2CR8_uc010zhy.1_Missense_Mutation_p.N139S|ALS2CR8_uc010zhz.1_RNA|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.N63S|ALS2CR8_uc010zib.1_Missense_Mutation_p.N63S|ALS2CR8_uc010zic.1_Missense_Mutation_p.N51S|ALS2CR8_uc002uzp.2_Missense_Mutation_p.N139S	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	139										large_intestine(1)|ovary(1)	2						GTGGATGTGAATAGTCCTCGG	0.418													30	38					0	0	0	0	G	203817391	G	G	203817391	3	3	288	1	0	0	0	0	1	0	0	0	555	101	4	5	426	5	ALS2CR8	2	203817391	Missense_Mutation	SNP	A	TCGA-DQ-7588-01A-11D-2078-08	6678554	203817391	39381982	23	53469											
HDLBP	3069	broad.mit.edu	37	chr2	242206304	242206304	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggttgatctcacacctacaCacaatccgggaaaaccacta	14	8	6	13	1	1	1	1	1	1	0	3	2	2	2	3	2	2	1	3	2	5	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr2:242206304C>T	uc002waz.2	-	3	209	c.-19G>A	c.(-21--17)GTGTG>GTATG		HDLBP_uc002wba.2_Translation_Start_Site|HDLBP_uc002wbb.2_Missense_Mutation_p.C15Y|HDLBP_uc010fzn.1_Translation_Start_Site	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein						cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CACACCTACACACAATCCGGG	0.413													29	54					0	0	0	0	T	242206304	T	T	242206304	1	4	288	1	0	0	0	0	0	0	0	0	7064	493	17	4		4	HDLBP	2	242206304	Translation_Start_Site	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	38388913	242206304	993069	24	53470											
OXSR1	9943	broad.mit.edu	37	chr3	38271893	38271893	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaaaaaacattgcagagagCaccaaccatttctgaaagag	19	6	8	8	0	1	4	0	1	1	3	1	5	1	4	2	0	4	2	2	0	5	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:38271893C>A	uc003chy.2	+	10	1265	c.923C>A	c.(922-924)GCA>GAA	p.A308E	OXSR1_uc010hhb.2_Missense_Mutation_p.A242E|OXSR1_uc010hha.1_Missense_Mutation_p.A240E	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	308					intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TTGCAGAGAGCACCAACCATT	0.289													25	26					5.61819e-17	6.38226e-17	1	0	A	38271893	A	A	38271893	3	1	288	1	0	0	0	0	1	0	0	0	11390	710	25	4	961	4	OXSR1	3	38271893	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08		38271893	159750537	25	53471											
PHLDB2	90102	broad.mit.edu	37	chr3	111681154	111681154	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcttgctcaccagacaacatCtctaggtaagatttatttat	12	14	6	9	0	2	2	1	0	1	2	3	2	2	2	1	1	2	3	1	1	5	7			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:111681154C>G	uc010hqa.2	+	13	3483	c.3072C>G	c.(3070-3072)ATC>ATG	p.I1024M	PHLDB2_uc003dyc.2_Missense_Mutation_p.I1008M|PHLDB2_uc003dyd.2_Missense_Mutation_p.I981M|PHLDB2_uc003dyg.2_Missense_Mutation_p.I1024M|PHLDB2_uc003dyh.2_Missense_Mutation_p.I981M|PHLDB2_uc003dyi.2_Missense_Mutation_p.I515M|PHLDB2_uc003dyj.2_Missense_Mutation_p.I79M	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1024						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						CAGACAACATCTCTAGGTAAG	0.438													13	39					0	0	0	0	G	111681154	G	G	111681154	3	3	288	1	0	0	0	0	1	0	0	0	11907	903	32	2	3203	2	PHLDB2	3	111681154	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	73409261	111681154	86341276	26	53472											
KALRN	8997	broad.mit.edu	37	chr3	124103785	124103785	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggagatctacaaggcagctCgacacctggaggtgcgcatc	11	6	13	11	2	1	1	0	0	1	1	3	4	1	2	1	4	3	3	1	4	2	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:124103785C>T	uc003ehg.2	+	11	1985	c.1858C>T	c.(1858-1860)CGA>TGA	p.R620*	KALRN_uc010hrv.1_Nonsense_Mutation_p.R620*|KALRN_uc003ehf.1_Nonsense_Mutation_p.R620*|KALRN_uc011bjy.1_Nonsense_Mutation_p.R620*|KALRN_uc003ehh.1_5'UTR	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	620	Spectrin 3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CAAGGCAGCTCGACACCTGGA	0.567													23	39					0	0	0	0	T	124103785	T	T	124103785	4	4	288	1	0	0	0	0	0	1	0	0	8014	876	31	1	1900	1	KALRN	3	124103785	Nonsense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	12422631	124103785	73918645	27	53473											
PIK3CB	5291	broad.mit.edu	37	chr3	138431123	138431123	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttaaagtcaaaaaccatcgtAtttacccacgctacaggata	16	10	5	10	2	1	0	1	0	0	0	2	1	1	1	2	1	3	2	2	1	8	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:138431123A>T	uc011bmq.1	-	8	1326	c.1326T>A	c.(1324-1326)AAT>AAA	p.N442K	PIK3CB_uc011bmo.1_5'UTR|PIK3CB_uc011bmp.1_Missense_Mutation_p.N46K	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	442	C2 PI3K-type.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AAACCATCGTATTTACCCACG	0.343													7	21					0	0	0	0	T	138431123	T	T	138431123	3	4	288	1	0	0	0	0	1	0	0	0	11969	446	16	5	1944	5	PIK3CB	3	138431123	Missense_Mutation	SNP	A	TCGA-DQ-7588-01A-11D-2078-08	14327338	138431123	59591307	28	53474											
PLSCR4	57088	broad.mit.edu	37	chr3	145913053	145913053	+	Frame_Shift_Del	DEL	C	-	-																															tactgccgatgttggatatgCcatcaagggatttgacctgg																										TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:145913053delC	uc010huy.2	-	8	1132	c.803delG	c.(802-804)GGCfs	p.G268fs	PLSCR4_uc010huz.2_Frame_Shift_Del_p.G268fs|PLSCR4_uc003evt.3_Frame_Shift_Del_p.G268fs|PLSCR4_uc010hva.2_Frame_Shift_Del_p.G178fs|PLSCR4_uc003evu.3_Frame_Shift_Del_p.G163fs	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	268	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						GTTGGATATGCCATCAAGGGA	0.398													---	---	---								-	145913053	-	-	145913053	7	5	288	1	0	1	0	1	0	0	0	0	12167	739	26	0	194	0	PLSCR4	3	145913053	Frame_Shift_Del	DEL	C	TCGA-DQ-7588-01A-11D-2078-08	7481930	145913053	52109377	29	53475											
SGEF	26084	broad.mit.edu	37	chr3	153840682	153840682	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagagtgaggtcgataacGacgtggatagcccagggtct	11	7	16	7	3	1	2	0	1	1	1	2	6	1	3	1	4	2	0	1	4	2	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr3:153840682G>T	uc011bog.1	+	2	1112	c.901G>T	c.(901-903)GAC>TAC	p.D301Y	uc003ezu.1_5'Flank|SGEF_uc011boh.1_Missense_Mutation_p.D301Y	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	301					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GGTCGATAACGACGTGGATAG	0.592													5	9					1.23904e-05	1.28426e-05	1	0	T	153840682	T	T	153840682	3	4	288	1	0	0	0	0	1	0	0	0	14270	1058	37	3	903	3	SGEF	3	153840682	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	7927629	153840682	44181748	30	53476											
GUF1	60558	broad.mit.edu	37	chr4	44684387	44684387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtagcaaacttctttcttGccttcgaagcacagctatcg	9	13	7	12	2	2	0	0	0	2	0	4	1	2	0	1	0	5	4	1	0	4	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr4:44684387G>A	uc003gww.3	+	5	751	c.544G>A	c.(544-546)GCC>ACC	p.A182T	GUF1_uc010ifz.1_RNA	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	182					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						CTTCTTTCTTGCCTTCGAAGC	0.318													23	69					0	0	0	0	A	44684387	A	A	44684387	3	1	288	1	0	0	0	0	1	0	0	0	6938	1319	46	4	562	4	GUF1	4	44684387	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		44684387	146469889	31	53477											
AASDH	132949	broad.mit.edu	37	chr4	57244333	57244333	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccgaaaatgctggatatttgGtactatacacttatgaggca	13	12	9	7	1	0	1	0	1	0	0	0	3	0	2	1	3	3	3	1	3	7	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr4:57244333G>C	uc003hbn.2	-	4	802	c.649C>G	c.(649-651)CCA>GCA	p.P217A	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Missense_Mutation_p.P64A|AASDH_uc003hbo.2_Missense_Mutation_p.P117A|AASDH_uc011cab.1_Intron|AASDH_uc010ihc.2_Missense_Mutation_p.P217A|AASDH_uc003hbp.2_Missense_Mutation_p.P217A	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	217					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				TGGATATTTGGTACTATACAC	0.313													32	46					0	0	0	0	C	57244333	C	C	57244333	3	2	288	1	0	0	0	0	1	0	0	0	22	1261	44	4	2695	4	AASDH	4	57244333	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	12559946	57244333	133909943	32	53478											
CNOT6L	246175	broad.mit.edu	37	chr4	78641683	78641683	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagtggtctgaagggatgtGagggtgtggacacccagtga	10	8	18	5	0	1	3	0	3	1	0	1	6	1	5	1	4	0	0	1	4	2	0			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr4:78641683G>A	uc011ccd.1	-	12	1701	c.1570C>T	c.(1570-1572)CAC>TAC	p.H524Y	CNOT6L_uc003hks.2_Missense_Mutation_p.H524Y	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	524					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						GAAGGGATGTGAGGGTGTGGA	0.488													30	131					0	0	0	0	A	78641683	A	A	78641683	3	1	288	1	0	0	0	0	1	0	0	0	3638	1290	45	2	101	2	CNOT6L	4	78641683	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	21397350	78641683	112512593	33	53479											
GRID2	2895	broad.mit.edu	37	chr4	94377080	94377080	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatcaatgacgtctactactCtctacaactccatgtggttt	10	14	6	11	1	3	1	1	1	2	0	5	2	4	1	1	1	4	1	1	1	5	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr4:94377080C>G	uc011cdt.1	+	11	2071	c.1813C>G	c.(1813-1815)CTC>GTC	p.L605V	GRID2_uc011cdu.1_Missense_Mutation_p.L510V	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	605	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GTCTACTACTCTCTACAACTC	0.403													29	47					0	0	0	0	G	94377080	G	G	94377080	3	3	288	1	0	0	0	0	1	0	0	0	6811	913	32	2	1855	2	GRID2	4	94377080	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	15735397	94377080	96777196	34	53480											
NAF1	92345	broad.mit.edu	37	chr4	164050333	164050333	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaagtctcctgagataccaTatgttctgagttatagaaat	13	14	8	6	0	2	4	0	3	2	2	3	5	2	4	2	0	1	2	2	0	6	5			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr4:164050333T>C	uc003iqj.2	-	8	1395	c.1201A>G	c.(1201-1203)ATG>GTG	p.M401V	NAF1_uc010iqw.1_Intron	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	401					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				TGAGATACCATATGTTCTGAG	0.433													21	24					0	0	0	0	C	164050333	C	C	164050333	3	2	288	1	0	0	0	0	1	0	0	0	10193	1406	49	5	428	5	NAF1	4	164050333	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	69673253	164050333	27103943	35	53481											
DNAH5	1767	broad.mit.edu	37	chr5	13900460	13900460	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcaaagtttacaaacaatTcccctgtgcctggagccttc	10	11	8	12	0	1	0	1	0	0	0	3	1	2	1	4	2	4	1	4	2	4	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:13900460T>A	uc003jfd.2	-	15	2156	c.2114A>T	c.(2113-2115)GAA>GTA	p.E705V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	705	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TACAAACAATTCCCCTGTGCC	0.428									Kartagener_syndrome				24	55					0	0	0	0	A	13900460	A	A	13900460	3	1	288	1	0	0	0	0	1	0	0	0	4626	1783	62	5	12020	5	DNAH5	5	13900460	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08		13900460	167014800	36	53482											
PRKAA1	5562	broad.mit.edu	37	chr5	40765031	40765031	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttggtgtttcagcaaccaaGaatggtactctttcaggatg	10	13	10	8	0	3	1	2	0	1	1	3	2	3	2	1	3	3	3	1	3	4	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:40765031G>A	uc003jmc.2	-	7	1137	c.1131C>T	c.(1129-1131)TTC>TTT	p.F377F	PRKAA1_uc003jmb.2_Silent_p.F392F	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	377					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	CAGCAACCAAGAATGGTACTC	0.428													8	34					0	0	0	0	A	40765031	A	A	40765031	2	1	288	1	0	0	0	0	0	0	0	1	12555	933	33	2		2	PRKAA1	5	40765031	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	26864571	40765031	140150229	37	53483											
PRKAA1	5562	broad.mit.edu	37	chr5	40765109	40765109	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgggcttgtcgccaaataGaaatctttggcttcattcat	9	14	10	8	1	3	1	2	0	1	1	4	1	3	1	1	3	0	2	1	3	3	5	rs116338283	by1000genomes	TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:40765109G>A	uc003jmc.2	-	7	1059	c.1053C>T	c.(1051-1053)TTC>TTT	p.F351F	PRKAA1_uc003jmb.2_Silent_p.F366F	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	351					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	TCGCCAAATAGAAATCTTTGG	0.433													18	57					0	0	0	0	A	40765109	A	A	40765109	2	1	288	1	0	0	0	0	0	0	0	1	12555	933	33	2		2	PRKAA1	5	40765109	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	78	40765109	140150151	38	53484											
ACTBL2	345651	broad.mit.edu	37	chr5	56777724	56777724	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcatggatcccactggactCaatgcccagaaaggaaggct	12	7	10	12	0	2	1	2	0	0	1	3	4	3	4	2	4	1	1	2	4	3	0			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:56777724C>G	uc003jrm.2	-	1	913	c.811G>C	c.(811-813)GAG>CAG	p.E271Q		NM_001017992	NP_001017992	Q562R1	ACTBL_HUMAN	actin, beta-like 2	271						cytoplasm|cytoskeleton	ATP binding			ovary(3)	3		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		CCACTGGACTCAATGCCCAGA	0.502													10	30					0	0	0	0	G	56777724	G	G	56777724	3	3	288	1	0	0	0	0	1	0	0	0	194	835	29	2	323	2	ACTBL2	5	56777724	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	16012615	56777724	124137536	39	53485											
CDO1	1036	broad.mit.edu	37	chr5	115148957	115148958	+	Splice_Site	INS	-	A	A																															acaagatttcgggtatacctINSaaaaaaaaacaatatattca																										TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:115148957_115148958insA	uc003krg.2	-	2	482	c.171_splice	c.e2-1	p.R57_splice		NM_001801	NP_001792	Q16878	CDO1_HUMAN	cysteine dioxygenase						inflammatory response|sulfur amino acid biosynthetic process|taurine biosynthetic process	cytosol	cysteine dioxygenase activity			large_intestine(1)|skin(1)	2		all_cancers(142;0.0046)|all_epithelial(76;0.000161)|Prostate(80;0.0132)|Ovarian(225;0.0776)		OV - Ovarian serous cystadenocarcinoma(64;7.8e-08)|Epithelial(69;7.32e-07)|all cancers(49;3.24e-05)	L-Cysteine(DB00151)|NADH(DB00157)	CGGGTATACCTAAAAAAAAACA	0.332													---	---	---								A	115148958	A	A	115148957	8	5	288	1	0	1	1	0	0	0	1	0	3184	1536	53	0	449	0	CDO1	5	115148957	Splice_Site	INS	-	TCGA-DQ-7588-01A-11D-2078-08	58371233	115148957	65766303	40	53486											
PCDHA2	56146	broad.mit.edu	37	chr5	140176801	140176801	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cgtggggagctggtcttactCgcagcagaggcggcagaggg	7	6	19	9	3	1	2	0	0	1	2	2	3	1	3	0	6	3	4	0	6	1	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:140176801C>G	uc003lhd.2	+	1	2358	c.2252C>G	c.(2251-2253)TCG>TGG	p.S751W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.S751W|PCDHA2_uc011czy.1_Missense_Mutation_p.S751W	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	751	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTCTTACTCGCAGCAGAGG	0.667													16	28					0	0	0	0	G	140176801	G	G	140176801	3	3	288	1	0	0	0	0	1	0	0	0	11578	893	31	3	2254	3	PCDHA2	5	140176801	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	25027844	140176801	40738459	41	53487											
HAVCR1	26762	broad.mit.edu	37	chr5	156464353	156464353	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtattggccgtcagtagaCtatgttctaggaacagttgc	9	13	12	7	1	2	1	1	0	1	1	2	2	2	2	1	3	2	4	1	3	5	7			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:156464353C>A	uc010jij.1	-	7	1042	c.857G>T	c.(856-858)AGT>ATT	p.S286I	HAVCR1_uc011ddl.1_Missense_Mutation_p.S117I|HAVCR1_uc003lwi.2_Missense_Mutation_p.S286I	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	281	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CGTCAGTAGACTATGTTCTAG	0.398													33	36					8.88839e-20	1.01786e-19	1	0	A	156464353	A	A	156464353	3	1	288	1	0	0	0	0	1	0	0	0	7012	565	20	4	249	4	HAVCR1	5	156464353	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	16287552	156464353	24450907	42	53488											
CNOT6	57472	broad.mit.edu	37	chr5	179980420	179980420	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ataacaacctgttacgagttCtaccttttgagctgggaaaa	13	12	8	8	1	1	1	0	1	1	0	1	3	1	2	2	1	5	3	2	1	6	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr5:179980420C>G	uc003mlx.2	+	4	683	c.334C>G	c.(334-336)CTA>GTA	p.L112V	CNOT6_uc010jld.2_Missense_Mutation_p.L112V|CNOT6_uc010jle.2_Missense_Mutation_p.L112V	NM_015455	NP_056270	Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	112	LRR 3.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding				0	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)		GTTACGAGTTCTACCTTTTGA	0.353													5	23					0	0	0	0	G	179980420	G	G	179980420	3	3	288	1	0	0	0	0	1	0	0	0	3637	912	32	2	344	2	CNOT6	5	179980420	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	23516067	179980420	934840	43	53489											
RING1	6015	broad.mit.edu	37	chr6	33180132	33180132	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaattctggaaggtgtccCggccactggagctgtgctat	9	10	13	9	1	1	1	0	0	1	1	2	3	2	3	2	4	2	2	2	4	3	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr6:33180132C>T	uc003odk.2	+	7	1371	c.1177C>T	c.(1177-1179)CGG>TGG	p.R393W	RING1_uc003odl.2_Missense_Mutation_p.R364W	NM_002931	NP_002922	Q06587	RING1_HUMAN	ring finger protein 1	393	Necessary for interaction with CBX2 (By similarity).				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GAAGGTGTCCCGGCCACTGGA	0.478													4	7					0	0	0	0	T	33180132	T	T	33180132	3	4	288	1	0	0	0	0	1	0	0	0	13439	643	23	1	1199	1	RING1	6	33180132	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08		33180132	137934935	44	53490											
ABCC10	89845	broad.mit.edu	37	chr6	43413617	43413617	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctcaccctgtctccactgtAtagccatctggccgatacct	7	11	6	17	1	3	0	1	0	2	0	4	1	3	0	6	1	2	1	6	1	3	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr6:43413617A>G	uc003ouy.1	+	15	3526	c.3311A>G	c.(3310-3312)TAT>TGT	p.Y1104C	ABCC10_uc003ouz.1_Missense_Mutation_p.Y1076C|ABCC10_uc010jyo.1_Missense_Mutation_p.Y210C	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1104	ABC transmembrane type-1 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TCTCCACTGTATAGCCATCTG	0.637													21	43					0	0	0	0	G	43413617	G	G	43413617	3	3	288	1	0	0	0	0	1	0	0	0	50	449	16	5	3277	5	ABCC10	6	43413617	Missense_Mutation	SNP	A	TCGA-DQ-7588-01A-11D-2078-08	10233485	43413617	127701450	45	53491											
GFRAL	389400	broad.mit.edu	37	chr6	55223758	55223758	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccatgaagatgagaattgCattagcaccttaagcaaaca	16	9	8	8	0	0	3	0	2	0	2	0	4	0	3	2	0	5	3	2	0	5	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr6:55223758C>A	uc003pcm.1	+	6	860	c.774C>A	c.(772-774)TGC>TGA	p.C258*		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	258	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ATGAGAATTGCATTAGCACCT	0.413													28	51					8.24728e-16	9.29456e-16	1	0	A	55223758	A	A	55223758	4	1	288	1	0	0	0	0	0	1	0	0	6388	718	25	4	796	4	GFRAL	6	55223758	Nonsense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	11810141	55223758	115891309	46	53492											
HDAC9	9734	broad.mit.edu	37	chr7	18688255	18688255	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcattcaacagcaacaccaGcaattcttggagaagcagaa	16	7	8	10	0	3	2	2	0	1	2	3	3	3	2	1	1	5	3	1	1	5	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr7:18688255G>C	uc003suh.2	+	10	1448	c.1407G>C	c.(1405-1407)CAG>CAC	p.Q469H	HDAC9_uc003sue.2_Missense_Mutation_p.Q469H|HDAC9_uc011jyd.1_Missense_Mutation_p.Q469H|HDAC9_uc003sui.2_Missense_Mutation_p.Q472H|HDAC9_uc003suj.2_Missense_Mutation_p.Q428H|HDAC9_uc011jya.1_Missense_Mutation_p.Q466H|HDAC9_uc003sua.1_Missense_Mutation_p.Q447H|HDAC9_uc011jyb.1_Missense_Mutation_p.Q425H|HDAC9_uc003sud.1_Missense_Mutation_p.Q469H|HDAC9_uc011jyc.1_Missense_Mutation_p.Q428H|HDAC9_uc003suf.1_Missense_Mutation_p.Q500H|HDAC9_uc010kud.1_Missense_Mutation_p.Q472H|HDAC9_uc011jye.1_Missense_Mutation_p.Q441H|HDAC9_uc011jyf.1_Missense_Mutation_p.Q392H|HDAC9_uc010kue.1_Missense_Mutation_p.Q212H	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	469					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	AGCAACACCAGCAATTCTTGG	0.498													16	23					0	0	0	0	C	18688255	C	C	18688255	3	2	288	1	0	0	0	0	1	0	0	0	7053	962	34	4	1454	4	HDAC9	7	18688255	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		18688255	140450408	47	53493											
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26232879	26232879	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttataaattacctccaccaTatggtccccccatgttcctg	9	14	4	14	0	0	0	0	0	0	0	3	0	3	0	7	1	1	1	7	1	5	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr7:26232879T>C	uc003sxr.3	-	10	1208	c.992A>G	c.(991-993)TAT>TGT	p.Y331C	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.Y319C	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	331	Gly-rich.|Nuclear targeting sequence (By similarity).				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ACCTCCACCATATGGTCCCCC	0.358			T	ETV1	prostate								29	59					0	0	0	0	C	26232879	C	C	26232879	3	2	288	1	0	0	0	0	1	0	0	0	7298	1406	49	5	77	5	HNRNPA2B1	7	26232879	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	7544624	26232879	132905784	48	53494											
SFRP4	6424	broad.mit.edu	37	chr7	37955807	37955807	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtggttgtacatcttcatGaggggctcgcagtcgtcgcg	5	12	14	10	4	2	1	1	1	1	0	5	1	2	1	0	3	1	4	0	3	1	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr7:37955807G>A	uc003tfo.3	-	1	719	c.333C>T	c.(331-333)CTC>CTT	p.L111L		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	111	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						ACATCTTCATGAGGGGCTCGC	0.627													19	33					0	0	0	0	A	37955807	A	A	37955807	2	1	288	1	0	0	0	0	0	0	0	1	14228	1277	45	2		2	SFRP4	7	37955807	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	11722928	37955807	121182856	49	53495											
SEMA3A	10371	broad.mit.edu	37	chr7	83643661	83643661	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgaggtgggcactaatgaacTttggatctgagagacaaata	14	10	12	5	0	1	4	0	3	1	1	1	6	1	5	0	3	1	1	0	3	4	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr7:83643661T>A	uc003uhz.2	-	7	989	c.674A>T	c.(673-675)AAG>ATG	p.K225M		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	225	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ACTAATGAACTTTGGATCTGA	0.333													11	11					0	0	0	0	A	83643661	A	A	83643661	3	1	288	1	0	0	0	0	1	0	0	0	14089	1609	56	5	1685	5	SEMA3A	7	83643661	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	45687854	83643661	75495002	50	53496											
BLK	640	broad.mit.edu	37	chr8	11412840	11412840	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcttttcttccctaatgcaGagaagggggatggtctatgc	8	13	12	8	0	3	1	0	0	3	1	4	3	4	2	1	3	2	1	1	3	3	5			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr8:11412840G>C	uc003wty.2	+	8	1201	c.620_splice	c.e8-1	p.K207_splice	BLK_uc003wtz.2_Splice_Site_p.K136_splice	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase						intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CCCTAATGCAGAGAAGGGGGA	0.627													42	69					0	0	0	0	C	11412840	C	C	11412840	5	2	288	1	0	0	0	0	0	0	1	0	1447	956	33	2	645	2	BLK	8	11412840	Splice_Site	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		11412840	134951182	51	53497											
LZTS1	11178	broad.mit.edu	37	chr8	20107757	20107757	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggccctccagcttgccccGcgtgtccttcagctgtgcct	3	10	10	18	2	1	0	1	0	0	0	3	0	3	0	6	1	4	2	6	1	0	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr8:20107757G>A	uc003wzr.2	-	3	1378	c.1267C>T	c.(1267-1269)CGG>TGG	p.R423W	LZTS1_uc010ltg.1_Missense_Mutation_p.R423W	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	423					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		AGCTTGCCCCGCGTGTCCTTC	0.647													67	113					0	0	0	0	A	20107757	A	A	20107757	3	1	288	1	0	0	0	0	1	0	0	0	9189	1086	38	1	527	1	LZTS1	8	20107757	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	8694917	20107757	126256265	52	53498											
LGI3	203190	broad.mit.edu	37	chr8	22013886	22013889	+	Frame_Shift_Del	DEL	GCCT	-	-																															agggcaggttcctgggcaccGcctttgagtccacgcagaag																										TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr8:22013886_22013889delGCCT	uc003xav.2	-	1	456_459	c.167_170delAGGC	c.(166-171)AAGGCGfs	p.K56fs	SFTPC_uc003xaw.3_5'Flank|LGI3_uc010ltu.2_Frame_Shift_Del_p.K56fs	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	56_57	LRRNT.				exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CCTGGGCACCGCCTTTGAGTCCAC	0.672													---	---	---								-	22013889	-	-	22013886	7	5	288	1	0	1	0	1	0	0	0	0	8794	1087	38	0	1508	0	LGI3	8	22013886	Frame_Shift_Del	DEL	GCCT	TCGA-DQ-7588-01A-11D-2078-08	1906129	22013886	124350136	53	53499											
CSMD3	114788	broad.mit.edu	37	chr8	113871401	113871401	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtattcactgctgtgatgacCcagacacattgtgcattgct	9	13	9	10	0	1	3	1	2	0	1	1	3	1	3	1	0	3	4	1	0	1	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr8:113871401C>G	uc003ynu.2	-	11	1887	c.1728G>C	c.(1726-1728)TGG>TGC	p.W576C	CSMD3_uc003ynt.2_Missense_Mutation_p.W536C|CSMD3_uc011lhx.1_Missense_Mutation_p.W472C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	576	Extracellular (Potential).|CUB 3.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTGTGATGACCCAGACACATT	0.373										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	54					0	0	0	0	G	113871401	G	G	113871401	3	3	288	1	0	0	0	0	1	0	0	0	3963	624	22	4	9639	4	CSMD3	8	113871401	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	91857515	113871401	32492621	54	53500											
SLC30A8	169026	broad.mit.edu	37	chr8	118170016	118170016	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	catgtgagcgcctgctgtatCctgattaccagatccaggcg	8	10	11	12	2	0	3	0	2	0	1	2	3	2	3	4	1	3	2	4	1	2	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr8:118170016C>G	uc003yoh.2	+	4	735	c.505C>G	c.(505-507)CCT>GCT	p.P169A	SLC30A8_uc010mcz.2_Missense_Mutation_p.P120A|SLC30A8_uc011lia.1_Missense_Mutation_p.P120A|SLC30A8_uc003yog.2_Missense_Mutation_p.P120A	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	169	Extracellular (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CCTGCTGTATCCTGATTACCA	0.552													81	116					0	0	0	0	G	118170016	G	G	118170016	3	3	288	1	0	0	0	0	1	0	0	0	14625	855	30	2	519	2	SLC30A8	8	118170016	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	4298615	118170016	28194006	55	53501											
SMARCA2	6595	broad.mit.edu	37	chr9	2101568	2101568	+	Splice_Site	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttctatctctctcttttaaAggaatcctttgctgaacacc	9	17	4	11	0	3	1	0	1	3	0	6	2	4	2	2	1	2	1	2	1	5	5			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr9:2101568A>G	uc003zhc.2	+	22	3178	c.3079_splice	c.e22-2	p.E1027_splice	SMARCA2_uc003zhd.2_Splice_Site_p.E1027_splice|SMARCA2_uc010mha.2_Splice_Site_p.E960_splice	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated						chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TCTCTTTTAAAGGAATCCTTT	0.274													2	17					0	0	0	0	G	2101568	G	G	2101568	5	3	288	1	0	0	0	0	0	0	1	0	14833	86	3	5	3159	5	SMARCA2	9	2101568	Splice_Site	SNP	A	TCGA-DQ-7588-01A-11D-2078-08		2101568	139111863	56	53502											
TRAF2	7186	broad.mit.edu	37	chr9	139815644	139815644	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaggaagctgtggctggccGcatacccgccatcttctccc	6	8	10	17	2	2	0	0	0	2	0	3	1	2	1	5	3	2	3	5	3	2	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr9:139815644G>A	uc010nbu.2	+	10	1288	c.1115G>A	c.(1114-1116)CGC>CAC	p.R372H	TRAF2_uc004cjv.2_Missense_Mutation_p.R372H|TRAF2_uc011mek.1_Missense_Mutation_p.R361H|TRAF2_uc010nbw.2_Missense_Mutation_p.R347H	NM_021138	NP_066961	Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	372	MATH.				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		GTGGCTGGCCGCATACCCGCC	0.592													4	63					0	0	0	0	A	139815644	A	A	139815644	3	1	288	1	0	0	0	0	1	0	0	0	16505	1087	38	1	1145	1	TRAF2	9	139815644	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	137714076	139815644	1397787	57	53503											
CAMK1D	57118	broad.mit.edu	37	chr10	12856261	12856261	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttgagcagatcctcaaggcgGaatatgagtttgactctccc	10	11	10	10	1	2	4	1	3	1	1	4	5	3	5	2	2	1	2	2	2	3	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr10:12856261G>A	uc001ilo.2	+	7	944	c.709G>A	c.(709-711)GAA>AAA	p.E237K	CAMK1D_uc001iln.2_Missense_Mutation_p.E237K	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	237	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		CCTCAAGGCGGAATATGAGTT	0.522													27	26					0	0	0	0	A	12856261	A	A	12856261	3	1	288	1	0	0	0	0	1	0	0	0	2609	1175	41	2	735	2	CAMK1D	10	12856261	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		12856261	122678486	58	53504											
KIAA1217	56243	broad.mit.edu	37	chr10	24762687	24762687	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagaaatcaaggaaatatccGgatagccatttgcctacact	15	9	7	10	1	1	1	1	0	0	1	2	3	2	3	3	2	3	0	3	2	6	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr10:24762687G>A	uc001iru.3	+	6	1780	c.1377G>A	c.(1375-1377)CCG>CCA	p.P459P	KIAA1217_uc001irs.2_Silent_p.P379P|KIAA1217_uc001irt.3_Silent_p.P459P|KIAA1217_uc010qcy.1_Silent_p.P459P|KIAA1217_uc010qcz.1_Silent_p.P459P|KIAA1217_uc001irv.1_Silent_p.P309P|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Silent_p.P177P|KIAA1217_uc001irz.2_Silent_p.P177P|KIAA1217_uc001irx.2_Silent_p.P177P|KIAA1217_uc001iry.2_Silent_p.P177P	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	459					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GGAAATATCCGGATAGCCATT	0.502													5	51					0	0	0	0	A	24762687	A	A	24762687	2	1	288	1	0	0	0	0	0	0	0	1	8255	1103	39	1		1	KIAA1217	10	24762687	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	11906426	24762687	110772060	59	53505											
C10orf91	170393	broad.mit.edu	37	chr10	134261557	134261557	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtttcaggaatgcggccttcGaagcctgaagcggggaatgg	9	8	16	8	3	1	1	1	1	0	0	2	4	1	3	2	5	3	1	2	5	4	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr10:134261557G>A	uc001llm.2	+	3	470	c.430G>A	c.(430-432)GAA>AAA	p.E144K		NM_173541	NP_775812	Q5T1B1	CJ091_HUMAN	hypothetical protein LOC170393	144										ovary(1)	1		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;6.95e-05)|Epithelial(32;0.000142)|all cancers(32;0.000162)		TGCGGCCTTCGAAGCCTGAAG	0.662													22	59					0	0	0	0	A	134261557	A	A	134261557	3	1	288	1	0	0	0	0	1	0	0	0	1630	1059	37	1	440	1	C10orf91	10	134261557	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	109498870	134261557	1273190	60	53506											
KCNQ1	3784	broad.mit.edu	37	chr11	2799262	2799262	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccgcctgaaccgagtagaaGacaaggtaggctcacgcgcc	11	4	12	14	4	1	3	1	1	0	2	1	4	1	3	4	2	1	3	4	2	5	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:2799262G>C	uc001lwn.2	+	15	1897	c.1789G>C	c.(1789-1791)GAC>CAC	p.D597H	KCNQ1_uc009ydp.1_Missense_Mutation_p.D381H|KCNQ1_uc001lwo.2_Missense_Mutation_p.D470H	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	597	Subunits assembly domain.|Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CCGAGTAGAAGACAAGGTAGG	0.612													21	39					0	0	0	0	C	2799262	C	C	2799262	3	2	288	1	0	0	0	0	1	0	0	0	8121	942	33	2	1856	2	KCNQ1	11	2799262	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		2799262	132207254	61	53507											
HBD	3045	broad.mit.edu	37	chr11	5255582	5255582	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgataccaacctgcccagggCctcaccaccaactgcatcca	11	6	6	18	0	1	1	1	1	0	0	2	1	2	1	7	1	5	1	7	1	3	1	rs35152987	byFrequency	TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:5255582C>G	uc001maf.1	-	1	277	c.82G>C	c.(82-84)GCC>CCC	p.A28P		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	28					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGCCCAGGGCCTCACCACCA	0.517													19	38					0	0	0	0	G	5255582	G	G	5255582	3	3	288	1	0	0	0	0	1	0	0	0	7018	739	26	4	373	4	HBD	11	5255582	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	2456320	5255582	129750934	62	53508											
OR6A2	8590	broad.mit.edu	37	chr11	6815960	6815960	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttcacacatcccttctatAcatttctgctagctttcttg	8	18	3	12	0	4	0	1	0	3	0	5	0	5	0	1	0	3	2	1	0	3	8			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:6815960A>G	uc001mes.1	-	1	1180	c.980T>C	c.(979-981)GTA>GCA	p.V327A		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	327	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCCCTTCTATACATTTCTGCT	0.458													30	41					0	0	0	0	G	6815960	G	G	6815960	3	3	288	1	0	0	0	0	1	0	0	0	11240	391	14	5	7	5	OR6A2	11	6815960	Missense_Mutation	SNP	A	TCGA-DQ-7588-01A-11D-2078-08	1560378	6815960	128190556	63	53509											
NLRP14	338323	broad.mit.edu	37	chr11	7081185	7081185	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcaacttctcttctacaCaacaagagcctgacgcatct	11	11	5	14	1	4	2	1	1	3	1	5	2	4	2	1	0	4	1	1	0	4	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:7081185C>A	uc001mfb.1	+	9	3017	c.2694C>A	c.(2692-2694)CAC>CAA	p.H898Q		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	898					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CTCTTCTACACAACAAGAGCC	0.443													42	86					4.00102e-26	4.65692e-26	1	0	A	7081185	A	A	7081185	3	1	288	1	0	0	0	0	1	0	0	0	10530	477	17	4	2724	4	NLRP14	11	7081185	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	265225	7081185	127925331	64	53510											
USP47	55031	broad.mit.edu	37	chr11	11913622	11913622	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgtcagccaaagctactcCtactcatctattttgaataa	13	14	4	10	0	3	1	2	1	1	0	4	1	4	1	2	0	4	1	2	0	7	7			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:11913622C>G	uc001mjq.1	+	5	1288	c.525C>G	c.(523-525)TCC>TCG	p.S175S	USP47_uc001mjr.2_Silent_p.S87S|USP47_uc001mjs.2_Silent_p.S155S	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	175					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		AAAGCTACTCCTACTCATCTA	0.313													29	71					0	0	0	0	G	11913622	G	G	11913622	2	3	288	1	0	0	0	0	0	0	0	1	17146	668	24	4		4	USP47	11	11913622	Silent	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	4832437	11913622	123092894	65	53511											
SPTY2D1	144108	broad.mit.edu	37	chr11	18636404	18636404	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactggtcgtcgaagttcatGtggactgctcacaggccggc	7	9	13	12	3	2	0	2	0	0	0	4	2	2	1	1	4	1	2	1	4	1	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:18636404G>C	uc001moy.2	-	3	1633	c.1417C>G	c.(1417-1419)CAT>GAT	p.H473D	SPTY2D1_uc010rdi.1_Missense_Mutation_p.H473D	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	473	Ser-rich.									breast(1)	1						CGAAGTTCATGTGGACTGCTC	0.622													12	49					0	0	0	0	C	18636404	C	C	18636404	3	2	288	1	0	0	0	0	1	0	0	0	15192	1377	48	4	656	4	SPTY2D1	11	18636404	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	6722782	18636404	116370112	66	53512											
TMEM132A	54972	broad.mit.edu	37	chr11	60702152	60702152	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccacctcgtggcgccacaCgcccgcgtgctggactcgcg	4	6	12	19	7	0	0	0	0	0	0	3	1	1	1	4	2	1	1	4	2	0	0			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:60702152C>T	uc001nqj.2	+	9	1945	c.1752C>T	c.(1750-1752)CAC>CAT	p.H584H	TMEM132A_uc001nqi.2_Silent_p.H585H|TMEM132A_uc001nqm.2_Translation_Start_Site	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	584	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						TGGCGCCACACGCCCGCGTGC	0.721													10	9					0	0	0	0	T	60702152	T	T	60702152	2	4	288	1	0	0	0	0	0	0	0	1	16111	535	19	1		1	TMEM132A	11	60702152	Silent	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	42065748	60702152	74304364	67	53513											
AHNAK	79026	broad.mit.edu	37	chr11	62293458	62293458	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttccttcaggtccttcgaTattcacatcgggacattcaa	9	14	6	12	2	3	0	3	0	0	0	7	2	5	1	2	2	0	0	2	2	2	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:62293458T>C	uc001ntl.2	-	5	8731	c.8431A>G	c.(8431-8433)ATC>GTC	p.I2811V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2811					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GGTCCTTCGATATTCACATCG	0.448													22	153					0	0	0	0	C	62293458	C	C	62293458	3	2	288	1	0	0	0	0	1	0	0	0	414	1406	49	5	9361	5	AHNAK	11	62293458	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	1591306	62293458	72713058	68	53514											
ACY3	91703	broad.mit.edu	37	chr11	67412797	67412797	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agagtccaggttgtagctctCctccccagaccgctggtaca	8	9	10	14	1	1	2	0	0	1	2	4	2	3	2	5	2	2	5	5	2	2	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:67412797C>T	uc001omq.2	-	5	658	c.487G>A	c.(487-489)GAG>AAG	p.E163K		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	163					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	TTGTAGCTCTCCTCCCCAGAC	0.657													6	19					0	0	0	0	T	67412797	T	T	67412797	3	4	288	1	0	0	0	0	1	0	0	0	227	864	30	2	488	2	ACY3	11	67412797	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	5119339	67412797	67593719	69	53515											
C11orf54	28970	broad.mit.edu	37	chr11	93483549	93483549	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaagataactttgctgatgtCcaggtctctgtagttgattg	10	15	10	6	0	1	3	0	2	1	1	3	3	2	3	1	1	2	3	1	1	3	5			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr11:93483549C>A	uc009ywi.2	+	4	424	c.93C>A	c.(91-93)GTC>GTA	p.V31V	C11orf54_uc001pee.1_Silent_p.V31V|C11orf54_uc001pef.2_Silent_p.V31V|C11orf54_uc001peg.2_Silent_p.V31V|C11orf54_uc001peh.2_Silent_p.V31V|C11orf54_uc001pei.2_Silent_p.V12V|C11orf54_uc001pej.2_Silent_p.V12V	NM_014039	NP_054758	Q9H0W9	CK054_HUMAN	hypothetical protein LOC28970	31						nucleus	hydrolase activity, acting on ester bonds|protein binding|zinc ion binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTGCTGATGTCCAGGTCTCTG	0.338													20	14					3.5997e-14	4.02486e-14	1	0	A	93483549	A	A	93483549	2	1	288	1	0	0	0	0	0	0	0	1	1655	842	30	2		2	C11orf54	11	93483549	Silent	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	26070752	93483549	41522967	70	53516											
TAS2R19	259294	broad.mit.edu	37	chr12	11174444	11174444	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttgatgtgattatacacaGaaagtaaatggcaaataaca	19	10	8	4	0	0	3	0	2	0	1	0	3	0	3	0	1	2	3	0	1	7	5			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:11174444G>A	uc010shj.1	-	1	727	c.727C>T	c.(727-729)CTG>TTG	p.L243L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176888	NP_795369	P59542	T2R19_HUMAN	taste receptor, type 2, member 19	243	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1						ATTATACACAGAAAGTAAATG	0.428													35	95					0	0	0	0	A	11174444	A	A	11174444	2	1	288	1	0	0	0	0	0	0	0	1	15636	933	33	2		2	TAS2R19	12	11174444	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		11174444	122677451	71	53517											
PLEKHA5	54477	broad.mit.edu	37	chr12	19501415	19501415	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctaatggagaagaaaaatCagaacctgtttcagagatag	18	9	9	5	0	3	4	2	0	1	4	3	6	3	4	1	1	1	1	1	1	6	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:19501415C>A	uc001reb.2	+	19	2569	c.2483C>A	c.(2482-2484)TCA>TAA	p.S828*	PLEKHA5_uc010sie.1_Nonsense_Mutation_p.S989*|PLEKHA5_uc001rea.2_Nonsense_Mutation_p.S886*|PLEKHA5_uc009zin.2_Nonsense_Mutation_p.S586*|PLEKHA5_uc010sif.1_Nonsense_Mutation_p.S817*|PLEKHA5_uc010sig.1_Nonsense_Mutation_p.S810*|PLEKHA5_uc010sih.1_Nonsense_Mutation_p.S783*|PLEKHA5_uc001rec.1_Nonsense_Mutation_p.S637*|PLEKHA5_uc009zio.2_Intron	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	828							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GAAGAAAAATCAGAACCTGTT	0.353													26	36					1.33986e-20	1.54683e-20	1	0	A	19501415	A	A	19501415	4	1	288	1	0	0	0	0	0	1	0	0	12114	838	29	2	2875	2	PLEKHA5	12	19501415	Nonsense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	8326971	19501415	114350480	72	53518											
IPO8	10526	broad.mit.edu	37	chr12	30787082	30787082	+	Frame_Shift_Del	DEL	A	-	-																															caaggtcaagtggagtactgAacccctcaagcgcggtttct																										TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:30787082delA	uc001rjd.2	-	23	3004	c.2834delT	c.(2833-2835)TTCfs	p.F945fs	IPO8_uc001rje.1_Frame_Shift_Del_p.F434fs|IPO8_uc010sjt.1_Frame_Shift_Del_p.F740fs	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	945					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TGGAGTACTGAACCCCTCAAG	0.413													---	---	---								-	30787082	-	-	30787082	7	5	288	1	0	1	0	1	0	0	0	0	7837	246	9	0	291	0	IPO8	12	30787082	Frame_Shift_Del	DEL	A	TCGA-DQ-7588-01A-11D-2078-08	11285667	30787082	103064813	73	53519											
KRT86	3892	broad.mit.edu	37	chr12	52699102	52699102	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acagccgggacctgaacatgGactgcatcattgccgagatc	11	7	11	12	2	1	2	1	1	0	1	2	5	1	4	3	2	4	1	3	2	1	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:52699102G>C	uc010snq.1	+	6	947	c.814G>C	c.(814-816)GAC>CAC	p.D272H	KRT86_uc009zmg.2_Missense_Mutation_p.D272H|KRT81_uc001sac.2_Intron|KRT86_uc001sad.2_Missense_Mutation_p.D272H	NM_002284	NP_002275	O43790	KRT86_HUMAN	keratin 86	272	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCTGAACATGGACTGCATCAT	0.592													45	72					0	0	0	0	C	52699102	C	C	52699102	3	2	288	1	0	0	0	0	1	0	0	0	8539	1174	41	2	832	2	KRT86	12	52699102	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	21912020	52699102	81152793	74	53520											
SMARCC2	6601	broad.mit.edu	37	chr12	56575309	56575309	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgcttctggggttggtgaagGagagggggagcgcttcctct	5	11	18	7	1	2	2	0	1	2	1	3	4	3	3	1	6	2	3	1	6	1	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:56575309G>C	uc001skb.2	-	10	1019	c.913C>G	c.(913-915)CCT>GCT	p.P305A	SMARCC2_uc001skd.2_Missense_Mutation_p.P305A|SMARCC2_uc001ska.2_Missense_Mutation_p.P305A|SMARCC2_uc001skc.2_Missense_Mutation_p.P305A|SMARCC2_uc010sqf.1_Missense_Mutation_p.P194A	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	305					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GTTGGTGAAGGAGAGGGGGAG	0.507													27	53					0	0	0	0	C	56575309	C	C	56575309	3	2	288	1	0	0	0	0	1	0	0	0	14840	1174	41	2	2904	2	SMARCC2	12	56575309	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	3876207	56575309	77276586	75	53521											
LRIG3	121227	broad.mit.edu	37	chr12	59277366	59277366	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacatgattgcgttgtcacTcaggtctctgaaaaatcacc	12	11	8	10	1	4	3	3	2	1	1	5	3	4	3	1	1	1	1	1	1	2	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:59277366T>A	uc001sqr.2	-	11	1498	c.1252A>T	c.(1252-1254)AGT>TGT	p.S418C	LRIG3_uc009zqh.2_Missense_Mutation_p.S358C|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	418	LRR 15.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			GCGTTGTCACTCAGGTCTCTG	0.413													19	38					0	0	0	0	A	59277366	A	A	59277366	3	1	288	1	0	0	0	0	1	0	0	0	8996	1551	54	5	2143	5	LRIG3	12	59277366	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	2702057	59277366	74574529	76	53522											
LIN7A	8825	broad.mit.edu	37	chr12	81331433	81331433	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccttacctctgtccagggtGagcggctggaccactgtcaa	7	9	11	14	1	2	1	1	1	1	0	3	2	3	2	4	3	2	1	4	3	2	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:81331433G>C	uc001szj.1	-	1	262	c.69C>G	c.(67-69)CTC>CTG	p.L23L	LIN7A_uc001szk.1_RNA|MIR618_hsa-mir-618|MI0003632_5'Flank	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	23	Kinase interacting site.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						TGTCCAGGGTGAGCGGCTGGA	0.612													7	9					0	0	0	0	C	81331433	C	C	81331433	2	2	288	1	0	0	0	0	0	0	0	1	8852	1277	45	2		2	LIN7A	12	81331433	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	22054067	81331433	52520462	77	53523											
MED13L	23389	broad.mit.edu	37	chr12	116444184	116444184	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcgtggaatgacctggtgtAgtgacatccttggtaccaaa	10	10	13	8	1	0	2	0	2	0	0	1	3	1	3	3	4	1	2	3	4	4	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr12:116444184A>G	uc001tvw.2	-	12	2326	c.2271T>C	c.(2269-2271)ACT>ACC	p.T757T		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	757					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GACCTGGTGTAGTGACATCCT	0.418													23	46					0	0	0	0	G	116444184	G	G	116444184	2	3	288	1	0	0	0	0	0	0	0	1	9484	407	15	5		5	MED13L	12	116444184	Silent	SNP	A	TCGA-DQ-7588-01A-11D-2078-08	35112751	116444184	17407711	78	53524											
TEP1	7011	broad.mit.edu	37	chr14	20852263	20852263	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccttccgtggggcagcatCagccgttgcactgtgtcctg	5	10	13	13	2	1	0	1	0	0	0	3	0	3	0	4	2	4	4	4	2	0	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr14:20852263C>T	uc001vxe.2	-	24	3508	c.3468G>A	c.(3466-3468)CTG>CTA	p.L1156L	TEP1_uc010ahk.2_Silent_p.L506L|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.L1048L|TEP1_uc010tlh.1_5'Flank	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1156					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGGGCAGCATCAGCCGTTGCA	0.647													36	42					0	0	0	0	T	20852263	T	T	20852263	2	4	288	1	0	0	0	0	0	0	0	1	15825	813	29	2		2	TEP1	14	20852263	Silent	SNP	C	TCGA-DQ-7588-01A-11D-2078-08		20852263	86497277	79	53525											
JUB	84962	broad.mit.edu	37	chr14	23444271	23444271	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttgttgcaaacaatgcatcGgaaacagcctggatgatagg	13	9	11	8	1	0	1	0	1	0	0	1	3	0	3	1	3	5	3	1	3	4	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr14:23444271G>A	uc001whz.2	-	5	1658	c.1282C>T	c.(1282-1284)CGA>TGA	p.R428*	JUB_uc001why.2_Nonsense_Mutation_p.R11*	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	428	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		ACAATGCATCGGAAACAGCCT	0.532													52	20					0	0	0	0	A	23444271	A	A	23444271	4	1	288	1	0	0	0	0	0	1	0	0	8007	1124	39	1	350	1	JUB	14	23444271	Nonsense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	2592008	23444271	83905269	80	53526											
SYNE2	23224	broad.mit.edu	37	chr14	64519707	64519707	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aattacaaacccaagtatttGaaaaagaaaaggaacttgaa	22	8	6	5	0	0	3	0	2	0	1	0	4	0	4	1	1	3	1	1	1	11	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr14:64519707G>C	uc001xgm.2	+	48	9306	c.9076G>C	c.(9076-9078)GAA>CAA	p.E3026Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E3026Q|SYNE2_uc010apw.1_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3026	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCAAGTATTTGAAAAAGAAAA	0.318													25	37					0	0	0	0	C	64519707	C	C	64519707	3	2	288	1	0	0	0	0	1	0	0	0	15512	1291	45	2	9262	2	SYNE2	14	64519707	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	41075436	64519707	42829833	81	53527											
SYNE2	23224	broad.mit.edu	37	chr14	64519931	64519931	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccaagtgtttatgtgatgaGataataaagaaattaaatga	18	12	9	2	0	0	4	0	3	0	2	0	5	0	4	1	0	0	1	1	0	8	5			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr14:64519931G>C	uc001xgm.2	+	48	9530	c.9300G>C	c.(9298-9300)GAG>GAC	p.E3100D	SYNE2_uc001xgl.2_Missense_Mutation_p.E3100D|SYNE2_uc010apw.1_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3100	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TATGTGATGAGATAATAAAGA	0.333													19	30					0	0	0	0	C	64519931	C	C	64519931	3	2	288	1	0	0	0	0	1	0	0	0	15512	933	33	2	9486	2	SYNE2	14	64519931	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	224	64519931	42829609	82	53528											
MGA	23269	broad.mit.edu	37	chr15	41961802	41961802	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gactgaattctttgcagtaaCagcttatcagaacattcaga	14	12	7	8	0	3	3	2	1	1	2	3	4	3	3	0	0	4	3	0	0	4	5			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr15:41961802C>T	uc001zog.1	+	2	801	c.710C>T	c.(709-711)ACA>ATA	p.T237I	MGA_uc010ucy.1_Missense_Mutation_p.T237I|MGA_uc010ucz.1_Missense_Mutation_p.T237I	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	237	T-box.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TTTGCAGTAACAGCTTATCAG	0.428													15	19					0	0	0	0	T	41961802	T	T	41961802	3	4	288	1	0	0	0	0	1	0	0	0	9593	478	17	4	712	4	MGA	15	41961802	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08		41961802	60569590	83	53529											
USP8	9101	broad.mit.edu	37	chr15	50733619	50733619	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcgtgatgaggaaagggccTatgtactatatatgaaatac	15	11	10	5	1	0	3	0	3	0	0	1	4	0	4	1	2	2	1	1	2	8	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr15:50733619T>G	uc001zym.3	+	4	678	c.178T>G	c.(178-180)TAT>GAT	p.Y60D	USP8_uc001zyk.1_5'UTR|USP8_uc001zyl.3_Missense_Mutation_p.Y60D|USP8_uc001zyn.3_Missense_Mutation_p.Y60D|USP8_uc010ufh.1_Intron|USP8_uc010bev.1_5'UTR	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	60	MIT.				cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		GGAAAGGGCCTATGTACTATA	0.323													12	23					0	0	0	0	G	50733619	G	G	50733619	3	3	288	1	0	0	0	0	1	0	0	0	17157	1522	53	5	184	5	USP8	15	50733619	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	8771817	50733619	51797773	84	53530											
NR2F2	7026	broad.mit.edu	37	chr15	96875682	96875682	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacctgagctacacgtgccgCgccaaccggaactgtcccat	10	6	9	16	4	0	1	0	1	0	0	1	2	1	2	5	1	6	1	5	1	4	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr15:96875682C>A	uc010uri.1	+	1	1572	c.348C>A	c.(346-348)CGC>CGA	p.R116R	NR2F2_uc002btp.2_Intron|NR2F2_uc010urj.1_5'Flank|MIR1469_hsa-mir-1469|MI0007074_5'Flank|NR2F2_uc010urk.1_5'Flank	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	116	NR C4-type.|Nuclear receptor.				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			ACACGTGCCGCGCCAACCGGA	0.602													18	23					1.33834e-09	1.46188e-09	1	0	A	96875682	A	A	96875682	2	1	288	1	0	0	0	0	0	0	0	1	10682	755	27	3		3	NR2F2	15	96875682	Silent	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	46142063	96875682	5655710	85	53531											
SPNS1	83985	broad.mit.edu	37	chr16	28992919	28992919	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctcgtggtgggcagatctGagggctctggcaagaaagtg	9	8	16	8	1	2	3	0	1	2	2	3	3	2	3	1	4	0	3	1	4	2	0			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr16:28992919G>A	uc010vdi.1	+	7	932	c.792G>A	c.(790-792)CTG>CTA	p.L264L	uc010vct.1_Intron|SPNS1_uc002drx.2_Silent_p.L191L|SPNS1_uc002dsa.2_Silent_p.L264L|SPNS1_uc002drz.2_Silent_p.L264L|SPNS1_uc010byp.2_Silent_p.L242L|SPNS1_uc010byq.1_Silent_p.L196L	NM_001142448	NP_001135920	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 isoform 1	264					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding				0						GGGCAGATCTGAGGGCTCTGG	0.592											OREG0023712	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	54					0	0	0	0	A	28992919	A	A	28992919	2	1	288	1	0	0	0	0	0	0	0	1	15140	1277	45	2		2	SPNS1	16	28992919	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		28992919	61361834	86	53532											
RNF40	9810	broad.mit.edu	37	chr16	30780713	30780713	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcaggtccttggcctcaaGtcccaggtatggccgccgcc	6	7	13	15	2	1	0	1	0	0	0	3	1	3	0	6	4	1	2	6	4	2	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr16:30780713G>A	uc002dzq.2	+	16	2577	c.2454G>A	c.(2452-2454)AAG>AAA	p.K818K	RNF40_uc010caa.2_Silent_p.K818K|RNF40_uc010cab.2_Silent_p.K718K|RNF40_uc010vfa.1_Silent_p.K150K|RNF40_uc002dzr.2_Silent_p.K818K|RNF40_uc010vfb.1_Silent_p.K510K|RNF40_uc010vfc.1_Silent_p.K150K	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	818	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			TTGGCCTCAAGTCCCAGGTAT	0.597													23	42					0	0	0	0	A	30780713	A	A	30780713	2	1	288	1	0	0	0	0	0	0	0	1	13558	1020	36	4		4	RNF40	16	30780713	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	1787794	30780713	59574040	87	53533											
NUP93	9688	broad.mit.edu	37	chr16	56878497	56878497	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacaccaatgcgaggctggtGcagatggaggtcctcatgaa	11	7	14	9	1	1	2	1	1	0	1	2	5	2	3	2	4	2	2	2	4	2	0			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr16:56878497G>A	uc002eka.2	+	22	2557	c.2436G>A	c.(2434-2436)GTG>GTA	p.V812V	NUP93_uc002ekb.2_Silent_p.V689V|NUP93_uc010vhi.1_Silent_p.V689V	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	812					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						CGAGGCTGGTGCAGATGGAGG	0.537													22	42					0	0	0	0	A	56878497	A	A	56878497	2	1	288	1	0	0	0	0	0	0	0	1	10826	1306	46	4		4	NUP93	16	56878497	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	26097784	56878497	33476256	88	53534											
GLG1	2734	broad.mit.edu	37	chr16	74499652	74499652	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctgtctcctgcagcttaaaTactttttggtggcagcgggt	6	15	11	9	1	2	0	0	0	2	0	3	0	2	0	1	3	4	3	1	3	3	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr16:74499652T>C	uc002fcy.3	-	19	2639	c.2589A>G	c.(2587-2589)GTA>GTG	p.V863V	GLG1_uc002fcx.2_Silent_p.V863V|GLG1_uc002fcw.3_Silent_p.V852V|GLG1_uc002fcz.3_Silent_p.V280V	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	863	Cys-rich GLG1 13.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						GCAGCTTAAATACTTTTTGGT	0.458													65	194					0	0	0	0	C	74499652	C	C	74499652	2	2	288	1	0	0	0	0	0	0	0	1	6473	1393	49	5		5	GLG1	16	74499652	Silent	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	17621155	74499652	15855101	89	53535											
ABR	29	broad.mit.edu	37	chr17	1028566	1028566	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggagacgccatcccccccGccctggctgcgggcgctgag	4	4	16	17	4	0	2	0	1	0	1	1	3	1	2	5	4	1	2	5	4	0	0	rs143549153	byFrequency	TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:1028566G>A	uc002fsd.2	-	2	308	c.198C>T	c.(196-198)GGC>GGT	p.G66G	ABR_uc002fse.2_Silent_p.G20G|ABR_uc010cjq.1_Silent_p.G78G	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	66					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		CATCCCCCCCGCCCTGGCTGC	0.672													44	49					0	0	0	0	A	1028566	A	A	1028566	2	1	288	1	0	0	0	0	0	0	0	1	99	1074	38	1		1	ABR	17	1028566	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		1028566	80166644	90	53536											
GPR172B	55065	broad.mit.edu	37	chr17	4936879	4936880	+	Frame_Shift_Ins	INS	-	T	T																															atagggcaaacaggaaaagcINStctgcacagaaggcagcacg																										TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:4936879_4936880insT	uc002gap.3	-	3	1617_1618	c.904_905insA	c.(904-906)AGCfs	p.S302fs	GPR172B_uc002gao.3_Frame_Shift_Ins_p.S302fs|GPR172B_uc010ckw.2_Frame_Shift_Ins_p.S180fs|GPR172B_uc010ckx.2_Frame_Shift_Ins_p.S302fs	NM_001104577	NP_001098047	Q9NWF4	RFT_HUMAN	G protein-coupled receptor 172B precursor	302						integral to plasma membrane	receptor activity|riboflavin transporter activity				0						ACAGGAAAAGCTCTGCACAGAA	0.644													---	---	---								T	4936880	T	T	4936879	7	5	288	1	0	1	1	0	0	0	0	0	6708	797	28	0	453	0	GPR172B	17	4936879	Frame_Shift_Ins	INS	-	TCGA-DQ-7588-01A-11D-2078-08	3908313	4936879	76258331	91	53537											
TP53	7157	broad.mit.edu	37	chr17	7578398	7578398	+	Frame_Shift_Del	DEL	G	-	-																															atctgagcagcgctcatggtGggggcagcgcctcacaacct																								rs68130327		TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:7578398delG	uc002gim.2	-	5	726	c.532delC	c.(532-534)CACfs	p.H178fs	TP53_uc002gig.1_Frame_Shift_Del_p.H178fs|TP53_uc002gih.2_Frame_Shift_Del_p.H178fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.H46fs|TP53_uc010cng.1_Frame_Shift_Del_p.H46fs|TP53_uc002gii.1_Frame_Shift_Del_p.H46fs|TP53_uc010cnh.1_Frame_Shift_Del_p.H178fs|TP53_uc010cni.1_Frame_Shift_Del_p.H178fs|TP53_uc002gij.2_Frame_Shift_Del_p.H178fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.H85fs|TP53_uc002gio.2_Frame_Shift_Del_p.H46fs|TP53_uc010vug.1_Frame_Shift_Del_p.H139fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	178	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> L (in a sporadic cancer; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> HPHP (in a Burkitt lymphoma).|H -> D (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H178fs*69(13)|p.P177_C182delPHHERC(8)|p.H178Y(8)|p.0?(7)|p.H178P(6)|p.H178fs*3(5)|p.H178Q(5)|p.H178D(4)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.H178N(3)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.H178H(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.P177fs*69(1)|p.R175_H178>X(1)|p.H178_H179>QY(1)|p.H168fs*69(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.H178del(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.H178L(1)|p.R174fs*3(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGCTCATGGTGGGGGCAGCGC	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7578398	-	-	7578398	7	5	288	1	0	1	0	1	0	0	0	0	16448	1348	47	0	766	0	TP53	17	7578398	Frame_Shift_Del	DEL	G	TCGA-DQ-7588-01A-11D-2078-08	2641519	7578398	73616812	92	53538											
MYH1	4619	broad.mit.edu	37	chr17	10401226	10401226	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcctgcagacgctgagccAgcttcttcctatgaaatatg	10	11	8	12	1	1	3	0	2	1	1	3	3	3	3	3	0	3	3	3	0	3	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:10401226A>T	uc002gmo.2	-	31	4284	c.4190T>A	c.(4189-4191)CTG>CAG	p.L1397Q	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1397	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						ACGCTGAGCCAGCTTCTTCCT	0.453													5	30					0	0	0	0	T	10401226	T	T	10401226	3	4	288	1	0	0	0	0	1	0	0	0	10082	188	7	5	1669	5	MYH1	17	10401226	Missense_Mutation	SNP	A	TCGA-DQ-7588-01A-11D-2078-08	2822828	10401226	70793984	93	53539											
AKAP10	11216	broad.mit.edu	37	chr17	19843030	19843030	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatcaatataactcacttgtCatataaaatcatggcatcat	16	14	3	8	0	5	0	5	0	0	0	5	0	5	0	0	1	1	1	0	1	7	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:19843030C>T	uc002gwo.2	-	8	1455	c.1318G>A	c.(1318-1320)GAC>AAC	p.D440N	AKAP10_uc002gwp.1_Missense_Mutation_p.D440N|AKAP10_uc010cqw.1_Missense_Mutation_p.D440N	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	440	RGS 2.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					ACTCACTTGTCATATAAAATC	0.264													15	39					0	0	0	0	T	19843030	T	T	19843030	3	4	288	1	0	0	0	0	1	0	0	0	446	826	29	2	702	2	AKAP10	17	19843030	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	9441804	19843030	61352180	94	53540											
CACNG1	786	broad.mit.edu	37	chr17	65050172	65050172	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctcggagatcttcgaatTcaccactcagaagggtgagc	11	8	12	10	2	3	3	2	1	1	2	5	6	3	3	1	2	2	1	1	2	2	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:65050172T>A	uc002jfu.2	+	2	361	c.290T>A	c.(289-291)TTC>TAC	p.F97Y		NM_000727	NP_000718	Q06432	CCG1_HUMAN	voltage-dependent calcium channel gamma-1	97					muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	ATCTTCGAATTCACCACTCAG	0.537													29	40					0	0	0	0	A	65050172	A	A	65050172	3	1	288	1	0	0	0	0	1	0	0	0	2568	1783	62	5	296	5	CACNG1	17	65050172	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	45207142	65050172	16145038	95	53541											
ABCA9	10350	broad.mit.edu	37	chr17	67045471	67045471	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttcattatctcttgggtaGttttggattcaggtgcaaat	8	18	10	5	0	3	0	2	0	1	0	4	1	3	1	0	3	1	4	0	3	3	7			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:67045471G>C	uc002jhu.2	-	3	400	c.257C>G	c.(256-258)ACT>AGT	p.T86S	ABCA9_uc010dez.2_Missense_Mutation_p.T86S|ABCA9_uc002jhv.2_Missense_Mutation_p.T86S	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	86					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CTCTTGGGTAGTTTTGGATTC	0.368													31	50					0	0	0	0	C	67045471	C	C	67045471	3	2	288	1	0	0	0	0	1	0	0	0	39	1029	36	4	4765	4	ABCA9	17	67045471	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	1995299	67045471	14149739	96	53542											
TTYH2	94015	broad.mit.edu	37	chr17	72209806	72209806	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgcacgtcggcctgcgccTgcagcccgtgaacagcacct	6	5	11	19	5	0	1	0	1	0	0	1	1	0	1	5	1	5	3	5	1	1	0			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:72209806T>C	uc002jkc.2	+	1	111	c.80T>C	c.(79-81)CTG>CCG	p.L27P	TTYH2_uc010wqw.1_5'Flank|MGC16275_uc002jkb.2_5'Flank	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	27	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						GGCCTGCGCCTGCAGCCCGTG	0.701													16	16					0	0	0	0	C	72209806	C	C	72209806	3	2	288	1	0	0	0	0	1	0	0	0	16808	1580	55	5	82	5	TTYH2	17	72209806	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	5164335	72209806	8985404	97	53543											
QRICH2	84074	broad.mit.edu	37	chr17	74273270	74273270	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggcaatctggatctcttcagTaggatacaggccccggggaa	10	8	13	10	1	3	0	1	0	2	0	4	3	3	3	2	6	1	2	2	6	4	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:74273270T>C	uc002jrd.1	-	16	4921	c.4741A>G	c.(4741-4743)ACT>GCT	p.T1581A	QRICH2_uc010wsz.1_Intron|QRICH2_uc010dgw.1_Missense_Mutation_p.T425A	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1581							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						ATCTCTTCAGTAGGATACAGG	0.637													27	50					0	0	0	0	C	74273270	C	C	74273270	3	2	288	1	0	0	0	0	1	0	0	0	12945	1638	57	5	266	5	QRICH2	17	74273270	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	2063464	74273270	6921940	98	53544											
TNRC6C	57690	broad.mit.edu	37	chr17	76094475	76094475	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctggccctacctcccacaCgcaagcctctctgtctcatg	6	10	6	19	1	3	0	1	0	3	0	6	0	4	0	4	1	2	1	4	1	2	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr17:76094475C>A	uc002jud.2	+	18	4958	c.4358C>A	c.(4357-4359)ACG>AAG	p.T1453K	TNRC6C_uc002juf.2_Missense_Mutation_p.T1489K	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1453	Sufficient for translational repression when tethered to a target mRNA.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			ACCTCCCACACGCAAGCCTCT	0.527													11	21					4.68919e-08	5.04443e-08	1	0	A	76094475	A	A	76094475	3	1	288	1	0	0	0	0	1	0	0	0	16408	536	19	3	4537	3	TNRC6C	17	76094475	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	1821205	76094475	5100735	99	53545											
STARD6	147323	broad.mit.edu	37	chr18	51851189	51851189	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcaattattgatggggacAattttcctctcatttctgtc	8	19	6	8	0	3	1	2	1	2	0	6	2	4	2	1	2	0	0	1	2	3	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr18:51851189A>T	uc010xdt.1	-	6	536	c.536T>A	c.(535-537)TTG>TAG	p.L179*		NM_139171	NP_631910	P59095	STAR6_HUMAN	START domain containing protein 6	179	START.				lipid transport		lipid binding			ovary(1)	1				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		TGATGGGGACAATTTTCCTCT	0.348													19	32					0	0	0	0	T	51851189	T	T	51851189	4	4	288	1	0	0	0	0	0	1	0	0	15327	131	5	5	129	5	STARD6	18	51851189	Nonsense_Mutation	SNP	A	TCGA-DQ-7588-01A-11D-2078-08		51851189	26226059	100	53546											
ZNF558	148156	broad.mit.edu	37	chr19	8932738	8932738	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccctgtgtgtgtcctttttGctgagaggctgggaacaggg	5	12	16	8	0	0	1	0	1	0	1	1	3	1	2	2	3	2	2	2	3	1	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:8932738G>T	uc002mkn.1	-	2	291	c.61C>A	c.(61-63)CAA>AAA	p.Q21K	ZNF558_uc010xkh.1_5'Flank|ZNF558_uc010dwg.1_Missense_Mutation_p.Q21K	NM_144693	NP_653294	Q96NG5	ZN558_HUMAN	zinc finger protein 558	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1						TGTCCTTTTTGCTGAGAGGCT	0.522													3	70					0.00024832	0.000255518	1	0	T	8932738	T	T	8932738	3	4	288	1	0	0	0	0	1	0	0	0	18056	1328	46	4	1167	4	ZNF558	19	8932738	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		8932738	50196245	101	53547											
DNMT1	1786	broad.mit.edu	37	chr19	10249209	10249209	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagtggctccgggaacagagGgagcttctctccaggggccg	7	6	16	12	2	1	1	0	0	1	1	4	3	3	3	3	5	2	2	3	5	1	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:10249209G>A	uc002mng.2	-	34	4153	c.3973C>T	c.(3973-3975)CCT>TCT	p.P1325S	DNMT1_uc002mne.2_RNA|DNMT1_uc002mnf.2_Missense_Mutation_p.P249S|DNMT1_uc010xlc.1_Missense_Mutation_p.P1341S|DNMT1_uc002mnh.2_Missense_Mutation_p.P1220S|DNMT1_uc010xld.1_Missense_Mutation_p.P1325S	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1325	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GGGAACAGAGGGAGCTTCTCT	0.637													10	39					0	0	0	0	A	10249209	A	A	10249209	3	1	288	1	0	0	0	0	1	0	0	0	4697	1232	43	4	905	4	DNMT1	19	10249209	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	1316471	10249209	48879774	102	53548											
KEAP1	9817	broad.mit.edu	37	chr19	10600446	10600446	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccacggcataaaggagaCgattgaggacagccacgccc	12	3	11	15	3	0	2	0	1	0	1	0	5	0	3	4	3	1	1	4	3	2	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:10600446C>T	uc002moq.1	-	4	1565	c.1409G>A	c.(1408-1410)CGT>CAT	p.R470H	KEAP1_uc002mop.1_Missense_Mutation_p.R188H|KEAP1_uc002mor.1_Missense_Mutation_p.R470H	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	470	Kelch 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ATAAAGGAGACGATTGAGGAC	0.562													15	20					0	0	0	0	T	10600446	T	T	10600446	3	4	288	1	0	0	0	0	1	0	0	0	8180	536	19	1	477	1	KEAP1	19	10600446	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	351237	10600446	48528537	103	53549											
LPPR2	64748	broad.mit.edu	37	chr19	11470232	11470232	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctgctgggcattgtgatcCtgcttgcttaccgcctggag	4	13	13	11	1	0	1	0	1	0	0	1	2	1	2	3	2	5	5	3	2	1	3			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:11470232C>T	uc002mre.1	+	4	428	c.91C>T	c.(91-93)CTG>TTG	p.L31L	LPPR2_uc002mrf.1_Intron|LPPR2_uc010dxy.1_5'Flank	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	31	Helical; (Potential).					integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						CATTGTGATCCTGCTTGCTTA	0.597													14	20					0	0	0	0	T	11470232	T	T	11470232	2	4	288	1	0	0	0	0	0	0	0	1	8975	680	24	4		4	LPPR2	19	11470232	Silent	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	869786	11470232	47658751	104	53550											
ZNF101	94039	broad.mit.edu	37	chr19	19790752	19790752	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcaaaaatgtgccaaagtCtttagatgtcccacgtccct	11	12	7	11	1	2	1	1	0	1	1	4	1	4	1	3	0	1	0	3	0	4	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:19790752C>G	uc002nni.1	+	4	1064	c.954C>G	c.(952-954)GTC>GTG	p.V318V	ZNF101_uc010ecg.1_Silent_p.V198V|ZNF101_uc002nnj.1_Silent_p.V198V	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	318	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GTGCCAAAGTCTTTAGATGTC	0.398													23	21					0	0	0	0	G	19790752	G	G	19790752	2	3	288	1	0	0	0	0	0	0	0	1	17781	900	32	2		2	ZNF101	19	19790752	Silent	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	8320520	19790752	39338231	105	53551											
ZNF708	7562	broad.mit.edu	37	chr19	21477105	21477105	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcttcacatttgtagggtttCtctccagtatgaattatctt	8	19	6	8	0	4	1	1	1	3	0	6	1	5	1	1	1	0	3	1	1	4	7			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:21477105C>T	uc002npq.1	-	4	861	c.663G>A	c.(661-663)GAG>GAA	p.E221E	ZNF708_uc002npr.1_Silent_p.E157E|ZNF708_uc010ecs.1_Silent_p.E157E	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						TGTAGGGTTTCTCTCCAGTAT	0.343													5	26					0	0	0	0	T	21477105	T	T	21477105	2	4	288	1	0	0	0	0	0	0	0	1	18179	912	32	2		2	ZNF708	19	21477105	Silent	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	1686353	21477105	37651878	106	53552											
ZNF99	7652	broad.mit.edu	37	chr19	22941528	22941528	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcacatttgtagggttTctgtccagtatgaattatct	8	19	7	7	0	4	1	1	1	3	0	5	1	5	1	1	1	0	3	1	1	4	7			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:22941528T>G	uc010xrh.1	-	5	910	c.910A>C	c.(910-912)AAA>CAA	p.K304Q		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTGTAGGGTTTCTGTCCAGTA	0.363													8	45					0	0	0	0	G	22941528	G	G	22941528	3	3	288	1	0	0	0	0	1	0	0	0	18271	1792	62	5	2214	5	ZNF99	19	22941528	Missense_Mutation	SNP	T	TCGA-DQ-7588-01A-11D-2078-08	1464423	22941528	36187455	107	53553											
SIPA1L3	23094	broad.mit.edu	37	chr19	38590721	38590721	+	Frame_Shift_Del	DEL	C	-	-																															gtcatccccgagctcaacatCcactgcctgcggctggccct																										TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:38590721delC	uc002ohk.2	+	5	2294	c.1785delC	c.(1783-1785)ATCfs	p.I595fs		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	595					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGCTCAACATCCACTGCCTGC	0.642													---	---	---								-	38590721	-	-	38590721	7	5	288	1	0	1	0	1	0	0	0	0	14396	845	30	0	1795	0	SIPA1L3	19	38590721	Frame_Shift_Del	DEL	C	TCGA-DQ-7588-01A-11D-2078-08	15649193	38590721	20538262	108	53554											
PPP1R15A	23645	broad.mit.edu	37	chr19	49379062	49379062	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccagagcctgggcacgcctCaggaacccacctttagcccc	8	5	10	18	1	1	1	1	0	0	1	1	2	1	2	7	2	3	1	7	2	2	2			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:49379062C>G	uc002pky.3	+	3	2126	c.1857C>G	c.(1855-1857)CTC>CTG	p.L619L		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	619					apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GGGCACGCCTCAGGAACCCAC	0.687													107	132					0	0	0	0	G	49379062	G	G	49379062	2	3	288	1	0	0	0	0	0	0	0	1	12423	813	29	2		2	PPP1R15A	19	49379062	Silent	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	10788341	49379062	9749921	109	53555											
ZNF347	84671	broad.mit.edu	37	chr19	53644812	53644812	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtaaggtttctctccagtGtgaattctccagtgatttgt	7	18	9	7	0	2	2	0	2	2	0	5	2	3	2	2	1	0	2	2	1	2	5			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:53644812G>A	uc002qbb.1	-	5	1338	c.1269C>T	c.(1267-1269)CAC>CAT	p.H423H	ZNF347_uc010eql.1_Silent_p.H424H|ZNF347_uc002qbc.1_Silent_p.H424H	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	423	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TCTCTCCAGTGTGAATTCTCC	0.428													46	57					0	0	0	0	A	53644812	A	A	53644812	2	1	288	1	0	0	0	0	0	0	0	1	17928	1368	48	4		4	ZNF347	19	53644812	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	4265750	53644812	5484171	110	53556											
LILRA3	11026	broad.mit.edu	37	chr19	54802685	54802685	+	Silent	SNP	G	A	A																															ttgtacagaacaaatctgtcGtagccggcatcagagccaca																										TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:54802685G>A	uc002qfd.2	-	5	821	c.756C>T	c.(754-756)TAC>TAT	p.Y252Y	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.Y188Y	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	252	Ig-like C2-type 3.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAAATCTGTCGTAGCCGGCAT	0.627													5	49					0	0	0	0	A	54802685	A	A	54802685	2	1	288	1	0	0	0	0	0	0	0	1	8827	1140	40	1		1	LILRA3	19	54802685	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	1157873	54802685	4326298	111	53557	123	2									
LILRA3	11026	broad.mit.edu	37	chr19	54802692	54802692	+	Missense_Mutation	SNP	G	A	A																															gaacaaatctgtcgtagccgGcatcagagccacactggaag																										TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr19:54802692G>A	uc002qfd.2	-	5	814	c.749C>T	c.(748-750)GCC>GTC	p.A250V	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Missense_Mutation_p.A186V	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	250	Ig-like C2-type 3.			A -> T (in Ref. 4; AAM18037).	defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTCGTAGCCGGCATCAGAGCC	0.612													4	51					0	0	0	0	A	54802692	A	A	54802692	3	1	288	1	0	0	0	0	1	0	0	0	8827	1203	42	4	582	4	LILRA3	19	54802692	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	7	54802692	4326291	112	53558	123	2									
ADAM33	80332	broad.mit.edu	37	chr20	3654911	3654911	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agttccaggtacttccgggtCctgcgcgcttctcgcctgcc	3	11	11	16	4	1	0	0	0	1	0	5	0	4	0	5	2	3	3	5	2	1	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr20:3654911C>A	uc002wit.2	-	7	708	c.621G>T	c.(619-621)AGG>AGT	p.R207S	ADAM33_uc002wir.1_Missense_Mutation_p.R207S|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Missense_Mutation_p.R207S|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Missense_Mutation_p.R130S|ADAM33_uc010zqg.1_Missense_Mutation_p.R219S|ADAM33_uc010zqh.1_Missense_Mutation_p.R207S	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	207	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						ACTTCCGGGTCCTGCGCGCTT	0.642													17	49					2.23348e-06	2.34929e-06	1	0	A	3654911	A	A	3654911	3	1	288	1	0	0	0	0	1	0	0	0	250	854	30	2	1884	2	ADAM33	20	3654911	Missense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08		3654911	59370609	113	53559											
DEFB115	245929	broad.mit.edu	37	chr20	29847327	29847327	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatcatgcaaagaaattgaGaggaagaaagaaaaatgtgg	22	6	11	2	0	1	4	1	1	0	4	1	6	1	5	0	2	1	1	0	2	7	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr20:29847327G>C	uc002wvp.1	+	2	159	c.159G>C	c.(157-159)GAG>GAC	p.E53D		NM_001037730	NP_001032819	Q30KQ5	DB115_HUMAN	beta-defensin 115 precursor	53					defense response to bacterium	extracellular region				ovary(1)	1			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			AAGAAATTGAGAGGAAGAAAG	0.353													19	26					0	0	0	0	C	29847327	C	C	29847327	3	2	288	1	0	0	0	0	1	0	0	0	4425	933	33	2	165	2	DEFB115	20	29847327	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	26192416	29847327	33178193	114	53560											
PLCG1	5335	broad.mit.edu	37	chr20	39797452	39797452	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acaaggcccagagggaggacGagctgaccttcatcaagagc	13	4	13	11	1	2	3	2	1	0	2	2	6	2	5	2	3	2	1	2	3	2	1			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr20:39797452G>C	uc002xjp.1	+	21	2546	c.2425G>C	c.(2425-2427)GAG>CAG	p.E809Q	PLCG1_uc002xjo.1_Missense_Mutation_p.E809Q|PLCG1_uc010zwe.1_Missense_Mutation_p.E435Q|PLCG1_uc010ggf.2_Missense_Mutation_p.E133Q	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	809	SH3.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GAGGGAGGACGAGCTGACCTT	0.577													6	17					0	0	0	0	C	39797452	C	C	39797452	3	2	288	1	0	0	0	0	1	0	0	0	12090	1059	37	3	2507	3	PLCG1	20	39797452	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	9950125	39797452	23228068	115	53561											
APP	351	broad.mit.edu	37	chr21	27348289	27348289	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggataactgccttcttatcaGctttaggcaagttctttgct	8	16	8	9	0	3	0	1	0	2	0	3	1	3	1	1	2	4	4	1	2	4	7			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr21:27348289G>A	uc002ylz.2	-	10	1477	c.1277C>T	c.(1276-1278)GCT>GTT	p.A426V	APP_uc010glk.2_Missense_Mutation_p.A402V|APP_uc002yma.2_Missense_Mutation_p.A407V|APP_uc011ach.1_Missense_Mutation_p.A370V|APP_uc002ymb.2_Missense_Mutation_p.A351V|APP_uc010glj.2_Missense_Mutation_p.A295V|APP_uc011aci.1_Missense_Mutation_p.A316V	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	426	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				CTTCTTATCAGCTTTAGGCAA	0.378													12	34					0	0	0	0	A	27348289	A	A	27348289	3	1	288	1	0	0	0	0	1	0	0	0	815	971	34	4	1071	4	APP	21	27348289	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		27348289	20781606	116	53562											
GART	2618	broad.mit.edu	37	chr21	34889435	34889435	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtagattctggtaggcgtGagaagtaagtcccctgcatg	9	11	13	8	1	1	2	0	1	1	2	2	3	2	2	2	2	1	4	2	2	4	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr21:34889435G>A	uc002yrx.2	-	16	2103	c.1968C>T	c.(1966-1968)CTC>CTT	p.L656L	GART_uc002yrz.2_Silent_p.L656L|GART_uc010gmd.2_Silent_p.L318L|GART_uc002yry.2_Silent_p.L656L	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	656	AIRS.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	TGGTAGGCGTGAGAAGTAAGT	0.423													70	34					0	0	0	0	A	34889435	A	A	34889435	2	1	288	1	0	0	0	0	0	0	0	1	6278	1277	45	2		2	GART	21	34889435	Silent	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	7541146	34889435	13240460	117	53563											
CECR2	27443	broad.mit.edu	37	chr22	18022014	18022014	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagcatgtatgctccagctCagttccagccaggattcatt	10	11	9	11	0	2	0	2	0	0	0	4	2	4	1	3	1	4	5	3	1	2	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr22:18022014C>T	uc010gqw.1	+	15	2242	c.2116C>T	c.(2116-2118)CAG>TAG	p.Q706*	CECR2_uc010gqv.1_Nonsense_Mutation_p.Q565*|CECR2_uc002zml.2_Nonsense_Mutation_p.Q565*	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	748					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		TGCTCCAGCTCAGTTCCAGCC	0.572													6	12					0	0	0	0	T	18022014	T	T	18022014	4	4	288	1	0	0	0	0	0	1	0	0	3221	827	29	2	2176	2	CECR2	22	18022014	Nonsense_Mutation	SNP	C	TCGA-DQ-7588-01A-11D-2078-08		18022014	33282552	118	53564											
EMID1	129080	broad.mit.edu	37	chr22	29627089	29627089	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctgccccgctctggggtccCcctcctgcccagggcagccc	2	6	11	22	1	1	0	0	0	1	0	3	0	3	0	8	3	3	2	8	3	0	0			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr22:29627089C>A	uc003aen.2	+	6	615	c.540C>A	c.(538-540)CCC>CCA	p.P180P	EMID1_uc003aem.2_Silent_p.P182P|EMID1_uc003aeo.2_Silent_p.P182P|EMID1_uc003aep.2_Silent_p.P182P	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	EMI domain containing 1	180	Collagen-like.					collagen					0						TCTGGGGTCCCCCTCCTGCCC	0.537													29	48					1.75199e-13	1.92854e-13	1	0	A	29627089	A	A	29627089	2	1	288	1	0	0	0	0	0	0	0	1	5115	610	22	4		4	EMID1	22	29627089	Silent	SNP	C	TCGA-DQ-7588-01A-11D-2078-08	11605075	29627089	21677477	119	53565											
FBXO7	25793	broad.mit.edu	37	chr22	32889111	32889111	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcactgaacctaccagatgtAtttgggttggtcgtcctccc	7	12	10	12	1	0	2	0	1	0	1	3	2	2	2	4	2	2	3	4	2	3	4			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chr22:32889111A>G	uc003amq.2	+	7	1270	c.987A>G	c.(985-987)GTA>GTG	p.V329V	FBXO7_uc003amr.2_Silent_p.V215V|FBXO7_uc003ams.2_Silent_p.V173V|FBXO7_uc003amt.2_Silent_p.V250V|FBXO7_uc003amu.2_Silent_p.V215V|FBXO7_uc003amv.2_Silent_p.V28V	NM_012179	NP_036311	Q9Y3I1	FBX7_HUMAN	F-box only protein 7 isoform 1	329	F-box.				cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						TACCAGATGTATTTGGGTTGG	0.438													42	91					0	0	0	0	G	32889111	G	G	32889111	2	3	288	1	0	0	0	0	0	0	0	1	5792	436	16	5		5	FBXO7	22	32889111	Silent	SNP	A	TCGA-DQ-7588-01A-11D-2078-08	3262022	32889111	18415455	120	53566											
PLCXD1	55344	broad.mit.edu	37	chrX	208211	208211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggctggagcggcatccacgcGaggtggtcatcctggcctgc	5	7	16	13	3	1	0	1	0	0	0	3	2	3	1	3	6	2	2	3	6	0	0			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chrX:208211G>A	uc004cpc.2	+	5	751	c.439G>A	c.(439-441)GAG>AAG	p.E147K	PLCXD1_uc011mgx.1_RNA	NM_018390	NP_060860	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X	147	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process		phospholipase C activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCATCCACGCGAGGTGGTCAT	0.607													16	46					0	0	0	0	A	208211	A	A	208211	3	1	288	1	0	0	0	0	1	0	0	0	12096	1059	37	1	453	1	PLCXD1	23	208211	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08		208211	155062349	121	53567											
GUCY2F	2986	broad.mit.edu	37	chrX	108641866	108641866	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagctatagacatctcctgcAaaagaacctaacctgctgcc	14	8	6	13	0	1	2	0	0	1	2	2	2	1	2	4	0	6	3	4	0	7	3	rs113612238		TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chrX:108641866A>C	uc004eod.3	-	11	2463	c.2187T>G	c.(2185-2187)TTT>TTG	p.F729L	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	729	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						CATCTCCTGCAAAAGAACCTA	0.502													25	11					0	0	0	0	C	108641866	C	C	108641866	3	2	288	1	0	0	0	0	1	0	0	0	6937	127	5	5	1175	5	GUCY2F	23	108641866	Missense_Mutation	SNP	A	TCGA-DQ-7588-01A-11D-2078-08	108433655	108641866	46628694	122	53568											
FMR1	2332	broad.mit.edu	37	chrX	147014272	147014272	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gatgtaatacaagttccaagGaacttagtaggtaagtcaga	16	10	10	5	0	1	1	1	0	0	1	2	3	2	2	1	2	2	4	1	2	8	6			TCGA-DQ-7588-01A-11D-2078-08	TCGA-DQ-7588-10B-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	6aad9b01-6a99-4f21-955f-7938af25a188	2805f3b2-5a20-4124-a730-3bb6ea20ffc0	g.chrX:147014272G>T	uc010nst.2	+	9	1059	c.870G>T	c.(868-870)AGG>AGT	p.R290S	FMR1_uc011mwz.1_Missense_Mutation_p.R290S|FMR1_uc004fcj.2_Missense_Mutation_p.R290S|FMR1_uc004fck.3_Missense_Mutation_p.R290S|FMR1_uc004fcl.3_Missense_Mutation_p.R151S|FMR1_uc011mxa.1_5'UTR	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	290	KH 2.				mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAGTTCCAAGGAACTTAGTAG	0.318									Fragile_X_syndrome				6	38					0.00116845	0.00119366	1	0	T	147014272	T	T	147014272	3	4	288	1	0	0	0	0	1	0	0	0	5992	1165	41	2	904	2	FMR1	23	147014272	Missense_Mutation	SNP	G	TCGA-DQ-7588-01A-11D-2078-08	38372406	147014272	8256288	123	53569											
PTCHD2	57540	broad.mit.edu	37	chr1	11561740	11561740	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcggctgagcaagaatgggCggtaccagcccagcatcccg	10	4	14	13	3	0	2	0	1	0	1	1	2	1	2	3	3	5	4	3	3	3	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:11561740C>T	uc001ash.3	+	2	829	c.691C>T	c.(691-693)CGG>TGG	p.R231W	PTCHD2_uc001asi.1_Missense_Mutation_p.R231W	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	231	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CAAGAATGGGCGGTACCAGCC	0.692													5	11					0	0	0	0	T	11561740	T	T	11561740	3	4	289	1	0	0	0	0	1	0	0	0	12795	759	27	1	693	1	PTCHD2	1	11561740	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08		11561740	237688881	1	53570											
NECAP2	55707	broad.mit.edu	37	chr1	16774625	16774625	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacttcaatgttgcattgcaGgaccatttcaagtgagtggg	10	12	12	7	0	2	1	2	1	0	0	2	3	2	2	1	2	2	3	1	2	2	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:16774625G>A	uc001ayo.2	+	4	459	c.369G>A	c.(367-369)CAG>CAA	p.Q123Q	NECAP2_uc001ayp.3_RNA|NECAP2_uc010ocd.1_Silent_p.Q97Q|NECAP2_uc001ayq.2_Silent_p.Q123Q	NM_018090	NP_060560	Q9NVZ3	NECP2_HUMAN	NECAP endocytosis associated 2 isoform 1	123					endocytosis|protein transport	clathrin vesicle coat|coated pit|plasma membrane					0		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|Kidney(64;0.000181)|KIRC - Kidney renal clear cell carcinoma(64;0.00268)|STAD - Stomach adenocarcinoma(196;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TTGCATTGCAGGACCATTTCA	0.522													34	102					0	0	0	0	A	16774625	A	A	16774625	2	1	289	1	0	0	0	0	0	0	0	1	10362	991	35	4		4	NECAP2	1	16774625	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	5212885	16774625	232475996	2	53571											
EPHA8	2046	broad.mit.edu	37	chr1	22921775	22921775	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atctgcctgacgctcatcacGggcctggtggtgcttctgct	4	12	12	13	2	4	1	2	1	2	0	4	1	4	1	2	3	3	3	2	3	0	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:22921775G>A	uc001bfx.1	+	8	1781	c.1656G>A	c.(1654-1656)ACG>ACA	p.T552T		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	552	Helical; (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CGCTCATCACGGGCCTGGTGG	0.642													9	37					0	0	0	0	A	22921775	A	A	22921775	2	1	289	1	0	0	0	0	0	0	0	1	5197	1103	39	1		1	EPHA8	1	22921775	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	6147150	22921775	226328846	3	53572											
PAQR7	164091	broad.mit.edu	37	chr1	26190068	26190068	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccacaaagagggccagcCgcagcagcagtaccagggcc	11	3	12	15	1	1	1	0	0	1	1	2	1	1	1	5	2	4	4	5	2	2	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:26190068C>A	uc001bkx.2	-	2	930	c.263G>T	c.(262-264)CGG>CTG	p.R88L		NM_178422	NP_848509	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	88	Helical; Name=1; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)	3		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGGCCAGCCGCAGCAGCAG	0.602													15	33					2.23348e-06	2.49986e-06	1	0	A	26190068	A	A	26190068	3	1	289	1	0	0	0	0	1	0	0	0	11494	652	23	3	781	3	PAQR7	1	26190068	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	3268293	26190068	223060553	4	53573											
DHDDS	79947	broad.mit.edu	37	chr1	26795572	26795572	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaggcttcctgcaggccttgGaactcaagcgagctgactgg	9	8	13	11	1	1	1	1	1	0	0	2	3	2	2	2	4	4	3	2	4	3	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:26795572G>C	uc001bml.2	+	9	1073	c.952G>C	c.(952-954)GAA>CAA	p.E318Q	DHDDS_uc001bmk.2_Missense_Mutation_p.E319Q|DHDDS_uc001bmm.2_Missense_Mutation_p.E225Q|DHDDS_uc001bmn.2_Missense_Mutation_p.E279Q|DHDDS_uc010ofd.1_Missense_Mutation_p.E284Q|uc001bmo.1_5'Flank	NM_205861	NP_995583	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase isoform b	318							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(3)	3		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		GCAGGCCTTGGAACTCAAGCG	0.652													23	49					0	0	0	0	C	26795572	C	C	26795572	3	2	289	1	0	0	0	0	1	0	0	0	4500	1175	41	2	985	2	DHDDS	1	26795572	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	605504	26795572	222455049	5	53574											
SLC9A1	6548	broad.mit.edu	37	chr1	27428887	27428889	+	In_Frame_Del	DEL	GGT	-	-																															agcactcactgcatggagacGgtggagacggcagaggggat																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:27428887_27428889delGGT	uc001bnm.2	-	8	2433_2435	c.1807_1809delACC	c.(1807-1809)ACCdel	p.T603del	SLC9A1_uc001bnl.2_In_Frame_Del_p.T107del|SLC9A1_uc010ofk.1_In_Frame_Del_p.T264del	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	603	Cytoplasmic (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	GCATGGAGACGGTGGAGACGGCA	0.65													---	---	---								-	27428889	-	-	27428887	7	5	289	1	0	1	0	1	0	0	0	0	14773	1103	39	0	658	0	SLC9A1	1	27428887	In_Frame_Del	DEL	GGT	TCGA-DQ-7589-01A-11D-2229-08	633315	27428887	221821734	6	53575											
ASB17	127247	broad.mit.edu	37	chr1	76397744	76397744	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aacttacttcaaaacggtatCctgatttttccacaaatgca	14	13	4	10	1	1	1	1	1	0	0	3	1	3	1	2	1	4	2	2	1	6	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:76397744C>A	uc001dhe.1	-	1	373	c.233G>T	c.(232-234)GGA>GTA	p.G78V	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	78					intracellular signal transduction					ovary(1)	1						AAAACGGTATCCTGATTTTTC	0.383													12	40					2.27111e-07	2.58949e-07	1	0	A	76397744	A	A	76397744	3	1	289	1	0	0	0	0	1	0	0	0	1023	855	30	2	666	2	ASB17	1	76397744	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	48968857	76397744	172852877	7	53576											
CTBS	1486	broad.mit.edu	37	chr1	85036299	85036299	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggctccttttgaatgagcGtagcacataagttctgagtc	9	13	10	9	1	1	3	0	3	1	0	3	3	2	3	1	1	2	4	1	1	3	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:85036299G>T	uc001dka.2	-	2	347	c.282C>A	c.(280-282)TAC>TAA	p.Y94*	CTBS_uc001dkc.2_Nonsense_Mutation_p.Y3*|CTBS_uc001dkd.2_5'UTR|CTBS_uc001dkb.2_5'UTR	NM_004388	NP_004379	Q01459	DIAC_HUMAN	chitobiase, di-N-acetyl- precursor	94						lysosome	cation binding				0				all cancers(265;0.00727)|Epithelial(280;0.0192)|OV - Ovarian serous cystadenocarcinoma(397;0.166)		TTGAATGAGCGTAGCACATAA	0.373													16	54					2.32416e-17	3.15052e-17	1	0	T	85036299	T	T	85036299	4	4	289	1	0	0	0	0	0	1	0	0	4016	1140	40	3	899	3	CTBS	1	85036299	Nonsense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	8638555	85036299	164214322	8	53577											
COL24A1	255631	broad.mit.edu	37	chr1	86252053	86252053	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtacctttgggccttgaattCctgggcttcctggcaagcct	5	13	11	12	0	0	1	0	1	0	0	2	1	2	1	5	3	2	3	5	3	3	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:86252053C>A	uc001dlj.2	-	48	4085	c.4043G>T	c.(4042-4044)GGA>GTA	p.G1348V	COL24A1_uc001dli.2_Missense_Mutation_p.G484V|COL24A1_uc010osd.1_Missense_Mutation_p.G648V|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1348	Collagen-like 15.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GCCTTGAATTCCTGGGCTTCC	0.502													21	69					1.77063e-15	2.36084e-15	1	0	A	86252053	A	A	86252053	3	1	289	1	0	0	0	0	1	0	0	0	3698	855	30	2	1153	2	COL24A1	1	86252053	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	1215754	86252053	162998568	9	53578											
OLFM3	118427	broad.mit.edu	37	chr1	102290583	102290583	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	attaaattgtcatactcactTagctttttcatgcagtcacg	11	16	5	9	1	4	0	4	0	0	0	4	0	4	0	0	0	3	2	0	0	4	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:102290583T>A	uc001duf.2	-	4	722	c.651A>T	c.(649-651)CTA>CTT	p.L217L	OLFM3_uc001dug.2_Silent_p.L197L|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Silent_p.L122L|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	217	Potential.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CATACTCACTTAGCTTTTTCA	0.343													9	27					0	0	0	0	A	102290583	A	A	102290583	2	1	289	1	0	0	0	0	0	0	0	1	10908	1768	61	5		5	OLFM3	1	102290583	Silent	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	16038530	102290583	146960038	10	53579											
HIST2H2AB	317772	broad.mit.edu	37	chr1	149859287	149859287	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccagctccagaatttccgcGgtcaggtactcgaggaccgc	8	7	12	14	4	1	1	1	0	0	1	4	3	3	2	4	3	2	2	4	3	2	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:149859287G>T	uc001ete.2	-	1	180	c.180C>A	c.(178-180)ACC>ACA	p.T60T	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	60					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GAATTTCCGCGGTCAGGTACT	0.662													36	41					9.65963e-10	1.14973e-09	1	0	T	149859287	T	T	149859287	2	4	289	1	0	0	0	0	0	0	0	1	7216	1103	39	3		3	HIST2H2AB	1	149859287	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	47568704	149859287	99391334	11	53580											
MTMR11	10903	broad.mit.edu	37	chr1	149906927	149906927	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctcaaaaccaactctgagCagccggaagtctcggccatg	11	6	10	14	2	3	1	1	1	2	0	4	2	3	2	4	2	4	1	4	2	4	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:149906927C>A	uc001etl.3	-	5	671	c.420G>T	c.(418-420)CTG>CTT	p.L140L	MTMR11_uc001etm.1_Silent_p.L68L|MTMR11_uc010pbm.1_Silent_p.L112L|MTMR11_uc010pbn.1_5'UTR	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	140							phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CAACTCTGAGCAGCCGGAAGT	0.557													14	29					0.000566183	0.000598046	1	0	A	149906927	A	A	149906927	2	1	289	1	0	0	0	0	0	0	0	1	9993	697	25	4		4	MTMR11	1	149906927	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	47640	149906927	99343694	12	53581											
NPR1	4881	broad.mit.edu	37	chr1	153660623	153660623	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagttggggctgctcatgcaGcggtgctgggctgaggaccc	5	8	18	10	1	1	1	1	1	0	0	1	3	1	2	1	5	4	6	1	5	0	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:153660623G>A	uc001fcs.3	+	15	2764	c.2343G>A	c.(2341-2343)CAG>CAA	p.Q781Q	NPR1_uc010pdz.1_Silent_p.Q527Q|NPR1_uc010pea.1_Silent_p.Q259Q	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	781	Cytoplasmic (Potential).|Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	TGCTCATGCAGCGGTGCTGGG	0.622													53	74					0	0	0	0	A	153660623	A	A	153660623	2	1	289	1	0	0	0	0	0	0	0	1	10648	962	34	4		4	NPR1	1	153660623	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	3753696	153660623	95589998	13	53582											
CACNA1E	777	broad.mit.edu	37	chr1	181546996	181546996	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcctttgaagctcgtgtcaGggatacctagtgagcatctg	8	11	13	9	1	2	2	1	2	1	0	3	3	2	3	2	2	3	2	2	2	3	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:181546996G>A	uc001gow.2	+	4	772	c.607G>A	c.(607-609)GGG>AGG	p.G203R	CACNA1E_uc009wxr.2_Missense_Mutation_p.G110R|CACNA1E_uc009wxs.2_Missense_Mutation_p.G110R	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	203	Helical; Name=S4 of repeat I.|I.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GCTCGTGTCAGGGATACCTAG	0.527													5	8					0	0	0	0	A	181546996	A	A	181546996	3	1	289	1	0	0	0	0	1	0	0	0	2554	1000	35	4	621	4	CACNA1E	1	181546996	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	27886373	181546996	67703625	14	53583											
RNPEP	6051	broad.mit.edu	37	chr1	201974779	201974779	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggagacttttgcatccaccGcctcccagctccacagcaat	10	8	7	16	1	0	1	0	0	0	1	3	2	3	1	5	1	3	3	5	1	1	2	rs148685424	byFrequency	TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:201974779G>A	uc001gxd.2	+	11	1917	c.1888G>A	c.(1888-1890)GCC>ACC	p.A630T	ELF3_uc001gxg.3_5'Flank|RNPEP_uc001gxe.2_Missense_Mutation_p.A331T|RNPEP_uc001gxf.2_Missense_Mutation_p.A499T	NM_020216	NP_064601	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase	630					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		TGCATCCACCGCCTCCCAGCT	0.582													25	99					0	0	0	0	A	201974779	A	A	201974779	3	1	289	1	0	0	0	0	1	0	0	0	13574	1087	38	1	1930	1	RNPEP	1	201974779	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	20427783	201974779	47275842	15	53584											
CHIT1	1118	broad.mit.edu	37	chr1	203192647	203192647	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accagggttgtgaagcgctcCttgtctacggcagggctccc	6	9	13	13	2	1	1	0	1	1	0	3	1	3	1	3	3	2	4	3	3	2	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:203192647C>T	uc001gzn.2	-	5	552	c.456G>A	c.(454-456)AAG>AAA	p.K152K	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_5'Flank|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Silent_p.K143K	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	152					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						TGAAGCGCTCCTTGTCTACGG	0.617													18	74					0	0	0	0	T	203192647	T	T	203192647	2	4	289	1	0	0	0	0	0	0	0	1	3361	680	24	4		4	CHIT1	1	203192647	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	1217868	203192647	46057974	16	53585											
PLEKHA6	22874	broad.mit.edu	37	chr1	204214757	204214757	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acccacctctgtgcttggcgGtgtccgtgccccgggagggg	3	8	16	14	3	1	0	0	0	1	0	2	1	2	1	5	5	2	1	5	5	0	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:204214757G>A	uc001hau.2	-	14	2335	c.2018C>T	c.(2017-2019)ACC>ATC	p.T673I	PLEKHA6_uc009xau.1_5'Flank|PLEKHA6_uc009xav.1_5'Flank	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	673										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GTGCTTGGCGGTGTCCGTGCC	0.607													20	76					0	0	0	0	A	204214757	A	A	204214757	3	1	289	1	0	0	0	0	1	0	0	0	12115	1261	44	4	1164	4	PLEKHA6	1	204214757	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	1022110	204214757	45035864	17	53586											
FLVCR1	28982	broad.mit.edu	37	chr1	213032065	213032065	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgggcgcgggagctgagaccCcgggggccgagagcagcccg	6	1	20	14	6	0	2	0	1	0	2	0	5	0	3	4	4	3	2	4	4	0	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:213032065C>T	uc001hjt.2	+	1	469	c.271C>T	c.(271-273)CCG>TCG	p.P91S	LQK1_uc001hjr.3_5'Flank|LQK1_uc001hjs.3_5'Flank	NM_014053	NP_054772	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular	91					cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		AGCTGAGACCCCGGGGGCCGA	0.711													4	9					0	0	0	0	T	213032065	T	T	213032065	3	4	289	1	0	0	0	0	1	0	0	0	5977	623	22	4	273	4	FLVCR1	1	213032065	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	8817308	213032065	36218556	18	53587											
RGS7	6000	broad.mit.edu	37	chr1	240979623	240979623	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataggttgactcacctgttgTtgtaactcatcttctgttgg	7	17	9	8	0	4	1	2	1	2	0	4	1	4	1	1	2	1	5	1	2	2	7			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:240979623T>C	uc001hyv.2	-	11	1107	c.777A>G	c.(775-777)CAA>CAG	p.Q259Q	RGS7_uc010pyh.1_Silent_p.Q233Q|RGS7_uc010pyj.1_Silent_p.Q175Q|RGS7_uc001hyu.2_Silent_p.Q259Q|RGS7_uc009xgn.1_Silent_p.Q206Q|RGS7_uc001hyw.2_Silent_p.Q259Q|RGS7_uc001hyt.2_Silent_p.Q91Q	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	259	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCACCTGTTGTTGTAACTCAT	0.373													35	135					0	0	0	0	C	240979623	C	C	240979623	2	2	289	1	0	0	0	0	0	0	0	1	13375	1722	60	5		5	RGS7	1	240979623	Silent	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	27947558	240979623	8270998	19	53588											
CEP170	9859	broad.mit.edu	37	chr1	243329016	243329016	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccctttgttcttgttgtTgaagttttgctaatgtttgc	4	21	8	8	0	1	1	0	1	1	0	2	1	2	1	2	0	2	6	2	0	2	9			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:243329016T>G	uc001hzs.2	-	13	2654	c.2246A>C	c.(2245-2247)CAA>CCA	p.Q749P	CEP170_uc001hzt.2_Missense_Mutation_p.Q651P|CEP170_uc001hzu.2_Missense_Mutation_p.Q651P|CEP170_uc001hzv.1_Missense_Mutation_p.Q127P	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	749						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TTCTTGTTGTTGAAGTTTTGC	0.378													32	136					0	0	0	0	G	243329016	G	G	243329016	3	3	289	1	0	0	0	0	1	0	0	0	3265	1812	63	5	2570	5	CEP170	1	243329016	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	2349393	243329016	5921605	20	53589											
OR2G2	81470	broad.mit.edu	37	chr1	247752084	247752084	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tacactgtcttaatgcatatCcatctctgcatggccttggc	8	14	7	12	0	2	0	0	0	2	0	4	0	3	0	2	2	3	2	2	2	3	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr1:247752084C>T	uc010pyy.1	+	1	423	c.423C>T	c.(421-423)ATC>ATT	p.I141I		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	141	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TAATGCATATCCATCTCTGCA	0.572													49	165					0	0	0	0	T	247752084	T	T	247752084	2	4	289	1	0	0	0	0	0	0	0	1	11052	845	30	2		2	OR2G2	1	247752084	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	4423068	247752084	1498537	21	53590											
MYT1L	23040	broad.mit.edu	37	chr2	1920986	1920986	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgtggacttactttctggagGgaccctatctttgtgcgggc	5	13	13	10	2	2	0	0	0	2	0	2	3	2	3	1	4	2	0	1	4	2	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:1920986G>T	uc002qxe.2	-	11	2436	c.1609C>A	c.(1609-1611)CCT>ACT	p.P537T	MYT1L_uc002qxd.2_Missense_Mutation_p.P535T|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	537					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTTTCTGGAGGGACCCTATCT	0.567													115	188					5.94928e-83	8.96064e-83	1	0	T	1920986	T	T	1920986	3	4	289	1	0	0	0	0	1	0	0	0	10160	1232	43	4	2011	4	MYT1L	2	1920986	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08		1920986	241278387	22	53591											
MYCN	4613	broad.mit.edu	37	chr2	16086155	16086155	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcaccagcttttgctggaaaAggaaaaattgcaggcaagac	15	7	11	8	0	0	1	0	0	0	1	0	3	0	3	1	3	3	5	1	3	5	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:16086155A>T	uc002rci.2	+	3	1631	c.1331A>T	c.(1330-1332)AAG>ATG	p.K444M	MYCN_uc010yjr.1_Missense_Mutation_p.K436M	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	444	Leucine-zipper.				regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			TTGCTGGAAAAGGAAAAATTG	0.488			A		neuroblastoma								43	156					0	0	0	0	T	16086155	T	T	16086155	3	4	289	1	0	0	0	0	1	0	0	0	10074	72	3	5	1337	5	MYCN	2	16086155	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	14165169	16086155	227113218	23	53592											
CLIP4	79745	broad.mit.edu	37	chr2	29404682	29404682	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atttcacctgtaagccgaacCatggagtcttagttcgaccg	10	11	9	11	3	2	0	1	0	1	0	3	3	2	1	4	1	2	2	4	1	3	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:29404682C>A	uc002rmv.2	+	16	2280	c.2041C>A	c.(2041-2043)CAT>AAT	p.H681N	CLIP4_uc002rmw.2_RNA	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	681	CAP-Gly 3.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					TAAGCCGAACCATGGAGTCTT	0.448													59	109					5.16434e-52	7.68352e-52	1	0	A	29404682	A	A	29404682	3	1	289	1	0	0	0	0	1	0	0	0	3550	594	21	4	2099	4	CLIP4	2	29404682	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	13318527	29404682	213794691	24	53593											
DYSF	8291	broad.mit.edu	37	chr2	71747932	71747932	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttagggcacgcctatctCaggaagtggctgctgctctc	6	11	11	13	1	3	0	1	0	3	0	5	1	3	1	1	3	2	4	1	3	3	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:71747932C>A	uc002sie.2	+	11	1327	c.951C>A	c.(949-951)CTC>CTA	p.L317L	DYSF_uc010feg.2_Silent_p.L348L|DYSF_uc010feh.2_Silent_p.L317L|DYSF_uc002sig.3_Silent_p.L317L|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.L317L|DYSF_uc010fef.2_Silent_p.L348L|DYSF_uc010fei.2_Silent_p.L348L|DYSF_uc010fek.2_Silent_p.L349L|DYSF_uc010fej.2_Silent_p.L318L|DYSF_uc010fel.2_Silent_p.L318L|DYSF_uc010feo.2_Silent_p.L349L|DYSF_uc010fem.2_Silent_p.L318L|DYSF_uc010fen.2_Silent_p.L349L|DYSF_uc002sif.2_Silent_p.L318L	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	317	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						ACGCCTATCTCAGGAAGTGGC	0.587													45	78					6.30371e-39	9.21021e-39	1	0	A	71747932	A	A	71747932	2	1	289	1	0	0	0	0	0	0	0	1	4881	813	29	2		2	DYSF	2	71747932	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	42343250	71747932	171451441	25	53594											
RAB11FIP5	26056	broad.mit.edu	37	chr2	73315279	73315279	+	Frame_Shift_Del	DEL	G	-	-																															tgtggggaggcccccaggatGggaccccccttttcccccag																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:73315279delG	uc002siu.3	-	3	1708	c.1467delC	c.(1465-1467)CCCfs	p.P489fs	RAB11FIP5_uc002sit.3_Frame_Shift_Del_p.P411fs	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	489					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CCCCCAGGATGGGACCCCCCT	0.607													---	---	---								-	73315279	-	-	73315279	7	5	289	1	0	1	0	1	0	0	0	0	12962	1335	47	0	506	0	RAB11FIP5	2	73315279	Frame_Shift_Del	DEL	G	TCGA-DQ-7589-01A-11D-2229-08	1567347	73315279	169884094	26	53595											
SULT1C2	6819	broad.mit.edu	37	chr2	108924878	108924878	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgatgaaatctatagaagAaagatggaaggaacctccat	17	10	9	5	0	1	5	0	2	1	3	2	7	2	7	2	2	1	0	2	2	7	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:108924878A>G	uc002tdy.2	+	8	1302	c.849A>G	c.(847-849)AGA>AGG	p.R283R	SULT1C2_uc002tdx.2_Silent_p.R294R|SULT1C2_uc010ywq.1_Silent_p.R297R	NM_001056	NP_001047	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 1	283					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			ovary(1)	1						TCTATAGAAGAAAGATGGAAG	0.408													24	43					0	0	0	0	G	108924878	G	G	108924878	2	3	289	1	0	0	0	0	0	0	0	1	15443	243	9	5		5	SULT1C2	2	108924878	Silent	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	35609599	108924878	134274495	27	53596											
POLR1B	84172	broad.mit.edu	37	chr2	113330186	113330186	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcacttatcaagaccgatcgGataacaaactgtatcgtctt	13	12	6	10	3	3	1	2	0	1	1	5	3	3	2	1	1	2	1	1	1	5	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:113330186G>A	uc002thw.2	+	13	2702	c.2122G>A	c.(2122-2124)GAT>AAT	p.D708N	POLR1B_uc010fkn.2_Missense_Mutation_p.D652N|POLR1B_uc002thx.2_Missense_Mutation_p.D569N|POLR1B_uc010fko.2_Missense_Mutation_p.D525N|POLR1B_uc010fkp.2_Missense_Mutation_p.D147N|POLR1B_uc010yxn.1_Missense_Mutation_p.D746N|POLR1B_uc002thy.2_Missense_Mutation_p.D569N|POLR1B_uc010yxo.1_Missense_Mutation_p.D485N	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	708					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						AGACCGATCGGATAACAAACT	0.403													25	51					0	0	0	0	A	113330186	A	A	113330186	3	1	289	1	0	0	0	0	1	0	0	0	12265	1174	41	2	2172	2	POLR1B	2	113330186	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	4405308	113330186	129869187	28	53597											
CNTNAP5	129684	broad.mit.edu	37	chr2	125192127	125192127	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gttcaatcagaagttgatgaGtactctcaaagatgtgatct	13	13	9	6	0	4	5	3	3	2	2	5	5	4	5	0	0	1	3	0	0	4	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:125192127G>A	uc002tno.2	+	5	960	c.596G>A	c.(595-597)AGT>AAT	p.S199N	CNTNAP5_uc010flu.2_Missense_Mutation_p.S199N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	199	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AAGTTGATGAGTACTCTCAAA	0.463													14	58					0	0	0	0	A	125192127	A	A	125192127	3	1	289	1	0	0	0	0	1	0	0	0	3665	1029	36	4	614	4	CNTNAP5	2	125192127	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	11861941	125192127	118007246	29	53598											
XIRP2	129446	broad.mit.edu	37	chr2	168104414	168104414	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcatccagtcagcatgcCagttggaggaacttacgacc	11	7	10	13	1	1	0	1	0	0	0	2	3	2	2	4	2	5	3	4	2	2	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:168104414C>A	uc002udx.2	+	8	6530	c.6512C>A	c.(6511-6513)CCA>CAA	p.P2171Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.P1996Q|XIRP2_uc010fpq.2_Missense_Mutation_p.P1949Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1996					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GTCAGCATGCCAGTTGGAGGA	0.353													9	37					0.000442599	0.00046954	1	0	A	168104414	A	A	168104414	3	1	289	1	0	0	0	0	1	0	0	0	17498	594	21	4	6542	4	XIRP2	2	168104414	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	42912287	168104414	75094959	30	53599											
ITGA4	3676	broad.mit.edu	37	chr2	182343549	182343549	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaatatccagtttttacacaAaggtaattgttcaaaaaata	18	13	5	5	0	1	0	1	0	0	0	2	1	2	0	1	1	1	3	1	1	9	8			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:182343549A>C	uc002unu.2	+	5	1385	c.622A>C	c.(622-624)AAG>CAG	p.K208Q	ITGA4_uc010zfl.1_Missense_Mutation_p.K208Q	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	208	FG-GAP 3.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TTTTTACACAAAGGTAATTGT	0.254													4	12					0	0	0	0	C	182343549	C	C	182343549	3	2	289	1	0	0	0	0	1	0	0	0	7917	15	1	5	640	5	ITGA4	2	182343549	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	14239135	182343549	60855824	31	53600											
COL3A1	1281	broad.mit.edu	37	chr2	189873733	189873733	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtggtgttggagccgcTgccattgctgggattggagg	4	12	19	6	1	0	0	0	0	0	0	0	3	0	3	2	6	3	3	2	6	0	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:189873733T>G	uc002uqj.1	+	48	3726	c.3609T>G	c.(3607-3609)GCT>GCG	p.A1203A		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1203	Nonhelical region (C-terminal).			A -> P (in Ref. 8; CAA33387).	axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.A1203T(1)		central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTGGAGCCGCTGCCATTGCTG	0.537													15	65					0	0	0	0	G	189873733	G	G	189873733	2	3	289	1	0	0	0	0	0	0	0	1	3703	1567	55	5		5	COL3A1	2	189873733	Silent	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	7530184	189873733	53325640	32	53601											
VIL1	7429	broad.mit.edu	37	chr2	219299411	219299411	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tcaagacccagtcttgctgcTatctatggtgtgggaaggtg	8	12	13	8	0	3	1	1	0	2	1	3	2	3	2	1	3	2	2	1	3	4	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:219299411T>A	uc002via.2	+	14	1728	c.1663T>A	c.(1663-1665)TAT>AAT	p.Y555N	VIL1_uc010zke.1_Missense_Mutation_p.Y244N|VIL1_uc002vib.2_Missense_Mutation_p.Y555N	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	555	Gelsolin-like 5.|Core.			Y->F: Complete loss of phosphorylation and interaction with PLCG1, does not reduce lamellipodium or ruffle localization, inhibits cell migration; when associated with F-46; F-60; F-81; F- 256; F-286; F-324; F-461; F-604 and F- 725. Inhibits interaction with PLCG1 and lamellipodia localization; when associated with F-286; F-324; F-461; F- 604 and F-725.	actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTCTTGCTGCTATCTATGGTG	0.577													31	37					0	0	0	0	A	219299411	A	A	219299411	3	1	289	1	0	0	0	0	1	0	0	0	17232	1522	53	5	1713	5	VIL1	2	219299411	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	29425678	219299411	23899962	33	53602											
PDCD1	5133	broad.mit.edu	37	chr2	242794394	242794394	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggccaggacccagactagcAgcaccaggctgcccagcagg	10	2	13	16	1	0	1	0	0	0	1	0	2	0	2	4	4	4	4	4	4	1	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr2:242794394A>T	uc002wcq.3	-	3	616	c.548T>A	c.(547-549)CTG>CAG	p.L183Q	PDCD1_uc010fzs.2_Intron|PDCD1_uc010fzt.2_RNA	NM_005018	NP_005009	Q15116	PDCD1_HUMAN	programmed cell death 1 precursor	183	Helical; (Potential).				apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			ovary(1)	1		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		CCAGACTAGCAGCACCAGGCT	0.682													7	12					0	0	0	0	T	242794394	T	T	242794394	3	4	289	1	0	0	0	0	1	0	0	0	11669	188	7	5	330	5	PDCD1	2	242794394	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	23494983	242794394	404979	34	53603											
UBE2E1	7324	broad.mit.edu	37	chr3	23932088	23932088	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agacagtggaccaagagataCgctacataaattggggtttc	14	9	11	7	1	0	2	0	0	0	2	1	4	0	3	1	3	2	2	1	3	5	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:23932088C>A	uc003cch.2	+	6	747	c.573C>A	c.(571-573)TAC>TAA	p.Y191*	UBE2E1_uc003cci.2_Nonsense_Mutation_p.Y174*	NM_003341	NP_003332	P51965	UB2E1_HUMAN	ubiquitin-conjugating enzyme E2E 1 isoform 1	191					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|histone H2B ubiquitination|histone monoubiquitination|ISG15-protein conjugation|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K48-linked ubiquitination	cytosol|nucleoplasm|ubiquitin ligase complex	ATP binding|ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity				0						CCAAGAGATACGCTACATAAA	0.458													13	26					0.00010058	0.000109073	1	0	A	23932088	A	A	23932088	4	1	289	1	0	0	0	0	0	1	0	0	16920	547	19	3	591	3	UBE2E1	3	23932088	Nonsense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08		23932088	174090342	35	53604											
PLXNB1	5364	broad.mit.edu	37	chr3	48453895	48453895	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggccacatactgggcaacCaggtcactgagcagagtgcg	10	7	13	11	1	1	2	1	1	0	1	1	2	1	2	2	3	4	2	2	3	2	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:48453895C>T	uc003csw.2	-	26	5259	c.4989G>A	c.(4987-4989)CTG>CTA	p.L1663L	PLXNB1_uc003cst.2_Silent_p.L113L|PLXNB1_uc003csu.2_Silent_p.L1480L|PLXNB1_uc003csx.2_Silent_p.L1663L	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	1663	Cytoplasmic (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACTGGGCAACCAGGTCACTGA	0.622													22	35					0	0	0	0	T	48453895	T	T	48453895	2	4	289	1	0	0	0	0	0	0	0	1	12178	581	21	4		4	PLXNB1	3	48453895	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	24521807	48453895	149568535	36	53605											
PDZRN3	23024	broad.mit.edu	37	chr3	73433743	73433743	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacaggccgtaaggggtggcGctcttcacctggcacttgag	7	9	14	11	2	2	1	1	1	1	0	2	1	2	1	2	5	1	3	2	5	2	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:73433743G>T	uc003dpl.1	-	10	2070	c.1974C>A	c.(1972-1974)AGC>AGA	p.S658R	PDZRN3_uc011bgh.1_Missense_Mutation_p.S315R|PDZRN3_uc010hoe.1_Missense_Mutation_p.S356R|PDZRN3_uc011bgf.1_Missense_Mutation_p.S375R|PDZRN3_uc011bgg.1_Missense_Mutation_p.S378R	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	658							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		AAGGGGTGGCGCTCTTCACCT	0.652													21	45					1.10513e-12	1.40444e-12	1	0	T	73433743	T	T	73433743	3	4	289	1	0	0	0	0	1	0	0	0	11763	1078	38	3	1230	3	PDZRN3	3	73433743	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	24979848	73433743	124588687	37	53606											
UMPS	7372	broad.mit.edu	37	chr3	124456711	124456711	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gagtgaagaggtttattcagGagaatgtctttgtggcagcg	10	12	15	4	1	2	3	1	1	1	2	2	5	2	3	0	3	1	2	0	3	3	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:124456711G>T	uc003ehl.3	+	3	713	c.607G>T	c.(607-609)GAG>TAG	p.E203*	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_Intron|UMPS_uc011bkb.1_Nonsense_Mutation_p.E111*|UMPS_uc011bkc.1_Nonsense_Mutation_p.E25*|UMPS_uc003ehn.3_Nonsense_Mutation_p.E25*|UMPS_uc011bkd.1_Nonsense_Mutation_p.E25*	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	203	OPRTase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)		GTTTATTCAGGAGAATGTCTT	0.473													8	23					4.68919e-08	5.42257e-08	1	0	T	124456711	T	T	124456711	4	4	289	1	0	0	0	0	0	1	0	0	17049	1175	41	2	617	2	UMPS	3	124456711	Nonsense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	51022968	124456711	73565719	38	53607											
BFSP2	8419	broad.mit.edu	37	chr3	133167440	133167440	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatggacctggagagtcaaaTagaaagtctgaaagaagaac	19	6	11	5	0	2	5	1	1	1	4	2	7	2	6	1	2	1	0	1	2	7	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:133167440T>C	uc003epn.1	+	3	818	c.680T>C	c.(679-681)ATA>ACA	p.I227T	uc003epo.2_Intron	NM_003571	NP_003562	Q13515	BFSP2_HUMAN	phakinin	227	Rod.|Potential.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens				0						GAGAGTCAAATAGAAAGTCTG	0.438													20	14					0	0	0	0	C	133167440	C	C	133167440	3	2	289	1	0	0	0	0	1	0	0	0	1419	1406	49	5	690	5	BFSP2	3	133167440	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	8710729	133167440	64854990	39	53608											
CEP70	80321	broad.mit.edu	37	chr3	138216951	138216951	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttccaatttgtagataaTgctgtttaaaaaatgcacaa	15	15	5	6	0	1	1	0	0	1	1	2	1	2	1	1	0	2	4	1	0	7	7			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:138216951T>C	uc003esl.2	-	17	1852	c.1654A>G	c.(1654-1656)ATT>GTT	p.I552V	CEP70_uc011bmk.1_Missense_Mutation_p.I532V|CEP70_uc011bml.1_Missense_Mutation_p.I534V|CEP70_uc011bmm.1_Missense_Mutation_p.I400V	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	552					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						TTGTAGATAATGCTGTTTAAA	0.328													32	22					0	0	0	0	C	138216951	C	C	138216951	3	2	289	1	0	0	0	0	1	0	0	0	3274	1478	51	5	147	5	CEP70	3	138216951	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	5049511	138216951	59805479	40	53609											
PIK3CB	5291	broad.mit.edu	37	chr3	138402532	138402532	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtacttaccatcaccattttTaaaaatcactccaactgaat	15	13	2	11	0	2	1	2	1	0	0	3	1	3	1	3	0	3	1	3	0	7	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:138402532T>C	uc011bmq.1	-	16	2413	c.2413A>G	c.(2413-2415)AAA>GAA	p.K805E	PIK3CB_uc011bmn.1_Missense_Mutation_p.K317E|PIK3CB_uc011bmo.1_Missense_Mutation_p.K251E|PIK3CB_uc011bmp.1_Missense_Mutation_p.K392E	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	805	PI3K/PI4K.			K->R: Loss of lipid kinase activity. May not affect insulin signaling and cell proliferation. Partially affects oncogene-induced trasformation.	activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						TCACCATTTTTAAAAATCACT	0.328													32	109					0	0	0	0	C	138402532	C	C	138402532	3	2	289	1	0	0	0	0	1	0	0	0	11969	1763	61	5	825	5	PIK3CB	3	138402532	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	185581	138402532	59619898	41	53610											
CLSTN2	64084	broad.mit.edu	37	chr3	140285008	140285008	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacagcgaagaggaggaggaGgaggaagggatgggcagagg	14	1	23	3	1	0	2	0	0	0	2	0	10	0	8	0	8	1	1	0	8	2	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:140285008G>A	uc003etn.2	+	17	2971	c.2781G>A	c.(2779-2781)GAG>GAA	p.E927E		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	927	Glu-rich (highly acidic).|Cytoplasmic (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						AGGAGGAGGAGGAGGAAGGGA	0.602										HNSCC(16;0.037)			4	16					0	0	0	0	A	140285008	A	A	140285008	2	1	289	1	0	0	0	0	0	0	0	1	3577	991	35	4		4	CLSTN2	3	140285008	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	1882476	140285008	57737422	42	53611											
GYG1	2992	broad.mit.edu	37	chr3	148714198	148714198	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagagttgggtgtcacgctgAcaaagctccactgctggtcg	8	9	13	11	2	1	2	1	1	0	1	3	2	2	2	1	2	2	4	1	2	1	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:148714198A>G	uc003ewn.2	+	3	306	c.253A>G	c.(253-255)ACA>GCA	p.T85A	GYG1_uc011bnp.1_Missense_Mutation_p.T85A|GYG1_uc003ewo.2_Missense_Mutation_p.T85A|GYG1_uc003ewp.2_Missense_Mutation_p.T85A	NM_004130	NP_004121	P46976	GLYG_HUMAN	glycogenin 1	85					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	glycogenin glucosyltransferase activity|metal ion binding|protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TGTCACGCTGACAAAGCTCCA	0.448													37	126					0	0	0	0	G	148714198	G	G	148714198	3	3	289	1	0	0	0	0	1	0	0	0	6944	275	10	5	263	5	GYG1	3	148714198	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	8429190	148714198	49308232	43	53612											
SI	6476	broad.mit.edu	37	chr3	164764695	164764695	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattccatttgttcccatgaAgcagtattgtctcctaacca	10	14	5	12	0	1	1	0	1	1	0	4	1	3	1	4	0	2	3	4	0	3	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:164764695A>T	uc003fei.2	-	16	1883	c.1821T>A	c.(1819-1821)GCT>GCA	p.A607A		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	607	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTTCCCATGAAGCAGTATTGT	0.388										HNSCC(35;0.089)			119	93					0	0	0	0	T	164764695	T	T	164764695	2	4	289	1	0	0	0	0	0	0	0	1	14362	59	3	5		5	SI	3	164764695	Silent	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	16050497	164764695	33257735	44	53613											
PIK3CA	5290	broad.mit.edu	37	chr3	178952072	178952072	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggagtatttcatgaaacaaAtgaatgatgcacatcatggt	15	12	9	5	0	2	3	2	3	0	0	2	4	2	4	0	2	2	2	0	2	4	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr3:178952072A>G	uc003fjk.2	+	21	3284	c.3127A>G	c.(3127-3129)ATG>GTG	p.M1043V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1043	PI3K/PI4K.		M -> I (in cancer; shows an increase in lipid kinase activity).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.M1043I(31)|p.M1043V(15)|p.M1043T(3)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CATGAAACAAATGAATGATGC	0.368		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			17	79					0	0	0	0	G	178952072	G	G	178952072	3	3	289	1	0	0	0	0	1	0	0	0	11968	101	4	5	3205	5	PIK3CA	3	178952072	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	14187377	178952072	19070358	45	53614											
MFSD7	84179	broad.mit.edu	37	chr4	680328	680328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtctgactcaccgccgcaCggagcccgacggagtccagg	7	4	15	15	5	2	1	1	1	1	0	3	4	3	3	4	4	1	1	4	4	0	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:680328C>T	uc003gay.2	-	2	344	c.287G>A	c.(286-288)CGT>CAT	p.R96H	MFSD7_uc003gaw.2_5'Flank|MFSD7_uc003gax.2_Missense_Mutation_p.R96H|MFSD7_uc003gaz.2_Missense_Mutation_p.R74H|MFSD7_uc003gba.2_Missense_Mutation_p.R96H|MFSD7_uc003gbb.1_Missense_Mutation_p.R32H	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	96					transmembrane transport	integral to membrane					0						CACCGCCGCACGGAGCCCGAC	0.662													13	55					0	0	0	0	T	680328	T	T	680328	3	4	289	1	0	0	0	0	1	0	0	0	9590	536	19	1	1428	1	MFSD7	4	680328	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08		680328	190473948	46	53615											
ZFYVE28	57732	broad.mit.edu	37	chr4	2306775	2306775	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gccctttctcctgggggtcgGcccaggtactgcctgcccac	3	9	12	17	1	1	0	0	0	1	0	3	0	1	0	5	4	3	1	5	4	1	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:2306775G>T	uc003gex.1	-	8	1611	c.1292C>A	c.(1291-1293)GCC>GAC	p.A431D	ZFYVE28_uc011bvk.1_Missense_Mutation_p.A361D|ZFYVE28_uc011bvl.1_Missense_Mutation_p.A401D|ZFYVE28_uc003gew.1_Missense_Mutation_p.A317D	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	431					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						CTGGGGGTCGGCCCAGGTACT	0.662													30	49					2.09667e-21	2.94015e-21	1	0	T	2306775	T	T	2306775	3	4	289	1	0	0	0	0	1	0	0	0	17737	1203	42	4	1395	4	ZFYVE28	4	2306775	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	1626447	2306775	188847501	47	53616											
GABRB1	2560	broad.mit.edu	37	chr4	47163273	47163273	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctttatttcacaggattataCactcaccatgtatttccagc	11	15	4	11	0	2	0	2	0	0	0	3	1	3	1	2	1	2	1	2	1	4	7			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:47163273C>T	uc003gxh.2	+	4	622	c.248C>T	c.(247-249)ACA>ATA	p.T83I	GABRB1_uc011bze.1_Missense_Mutation_p.T13I	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	83	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAGGATTATACACTCACCATG	0.353													12	36					0	0	0	0	T	47163273	T	T	47163273	3	4	289	1	0	0	0	0	1	0	0	0	6200	478	17	4	262	4	GABRB1	4	47163273	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	44856498	47163273	143991003	48	53617											
GABRB1	2560	broad.mit.edu	37	chr4	47427742	47427742	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctggaaatccggaatgagAcgagtggctcggaagtgctc	10	7	14	10	3	0	1	0	1	0	1	3	6	1	4	2	4	1	2	2	4	3	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:47427742A>T	uc003gxh.2	+	9	1506	c.1132A>T	c.(1132-1134)ACG>TCG	p.T378S	GABRB1_uc011bze.1_Missense_Mutation_p.T308S	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	378	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCGGAATGAGACGAGTGGCTC	0.587													22	73					0	0	0	0	T	47427742	T	T	47427742	3	4	289	1	0	0	0	0	1	0	0	0	6200	275	10	5	1166	5	GABRB1	4	47427742	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	264469	47427742	143726534	49	53618											
EPHA5	2044	broad.mit.edu	37	chr4	66213826	66213826	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccataagacacaacttcccaCattactattccataactcca	15	10	1	15	0	0	1	0	0	0	1	3	1	3	1	4	0	3	0	4	0	5	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:66213826C>A	uc003hcy.2	-	15	2797	c.2604G>T	c.(2602-2604)ATG>ATT	p.M868I	EPHA5_uc003hcx.2_Missense_Mutation_p.M800I|EPHA5_uc003hcz.2_Missense_Mutation_p.M846I|EPHA5_uc011cah.1_Missense_Mutation_p.M869I|EPHA5_uc011cai.1_Missense_Mutation_p.M847I|EPHA5_uc003hda.2_Missense_Mutation_p.M869I	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	868	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CAACTTCCCACATTACTATTC	0.423										TSP Lung(17;0.13)			43	102					1.23103e-26	1.74634e-26	1	0	A	66213826	A	A	66213826	3	1	289	1	0	0	0	0	1	0	0	0	5194	478	17	4	525	4	EPHA5	4	66213826	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	18786084	66213826	124940450	50	53619											
AFP	174	broad.mit.edu	37	chr4	74309071	74309071	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctctacatctaggcagcaaCagttacaaaagaattaagag	17	8	7	9	0	2	2	0	0	2	2	2	2	2	2	1	1	4	3	1	1	8	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:74309071C>T	uc003hgz.1	+	6	670	c.623C>T	c.(622-624)ACA>ATA	p.T208I	AFP_uc003hha.1_Missense_Mutation_p.T208I|AFP_uc011cbg.1_5'UTR	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	208	Albumin 1.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TAGGCAGCAACAGTTACAAAA	0.323									Alpha-Fetoprotein_Hereditary_Persistence_of				14	31					0	0	0	0	T	74309071	T	T	74309071	3	4	289	1	0	0	0	0	1	0	0	0	363	478	17	4	645	4	AFP	4	74309071	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	8095245	74309071	116845205	51	53620											
AFM	173	broad.mit.edu	37	chr4	74364895	74364895	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaactggtgtctcttggcGagaaaatggtgacagctttc	11	11	12	7	1	1	3	0	1	1	2	3	4	1	3	0	3	2	1	0	3	4	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:74364895G>T	uc003hhb.2	+	11	1385	c.1354G>T	c.(1354-1356)GAG>TAG	p.E452*		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	452	Albumin 3.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTCTCTTGGCGAGAAAATGGT	0.443													13	48					4.36969e-10	5.22649e-10	1	0	T	74364895	T	T	74364895	4	4	289	1	0	0	0	0	0	1	0	0	361	1059	37	3	1396	3	AFM	4	74364895	Nonsense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	55824	74364895	116789381	52	53621											
HERC6	55008	broad.mit.edu	37	chr4	89317238	89317239	+	Missense_Mutation	DNP	AG	CT	CT																															agccccactcctgagaagagAggtccacaacttgtggaaag																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:89317238_89317239AG>CT	uc011cdi.1	+	6	1014_1015	c.831_832AG>CT	c.(829-834)AGAGGT>AGCTGT	p.277_278RG>SC	HERC6_uc003hrp.1_RNA|HERC6_uc011cdj.1_Missense_Mutation_p.277_278RG>SC|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	277_278	RCC1 5.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		CTGAGAAGAGAGGTCCACAACT	0.431													14	28					0	0	0	0	CT	89317239	CT	CT	89317238	3	2	289	1	0	0	0	0	1	0	0	0	7101	301	11	5	650	5	HERC6	4	89317238	Missense_Mutation	DNP	AG	TCGA-DQ-7589-01A-11D-2229-08	14952343	89317238	101837038	53	53622											
CFI	3426	broad.mit.edu	37	chr4	110667554	110667554	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctgcattgtagttttcaTggaaaataattctatccacg	11	15	7	8	1	2	0	1	0	1	0	3	1	3	1	2	1	2	3	2	1	5	7	rs121964912		TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:110667554T>A	uc003hzr.3	-	11	1461	c.1253A>T	c.(1252-1254)CAT>CTT	p.H418L	CFI_uc003hzq.2_Missense_Mutation_p.H215L|CFI_uc011cft.1_Missense_Mutation_p.H426L|CFI_uc003hzs.3_Missense_Mutation_p.H411L	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	418	Peptidase S1.		H -> L (in CFI deficiency).		complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		GTAGTTTTCATGGAAAATAAT	0.373													38	22					0	0	0	0	A	110667554	A	A	110667554	3	1	289	1	0	0	0	0	1	0	0	0	3304	1464	51	5	510	5	CFI	4	110667554	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	21350316	110667554	80486722	54	53623											
ENPEP	2028	broad.mit.edu	37	chr4	111464192	111464192	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cattttcttcagcagatcgtGcaagtcttattgatgatgct	9	16	8	8	1	3	3	1	2	2	1	4	3	3	3	0	0	3	3	0	0	2	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:111464192G>T	uc003iab.3	+	13	2308	c.1966G>T	c.(1966-1968)GCA>TCA	p.A656S		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	656	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AGCAGATCGTGCAAGTCTTAT	0.323													35	53					2.24722e-20	3.11546e-20	1	0	T	111464192	T	T	111464192	3	4	289	1	0	0	0	0	1	0	0	0	5152	1319	46	4	2016	4	ENPEP	4	111464192	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	796638	111464192	79690084	55	53624											
C4orf31	79625	broad.mit.edu	37	chr4	121957957	121957957	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagaagtttcccatctcttCtcacttggatttggacagca	10	13	8	10	0	2	1	1	0	2	1	5	4	3	3	1	2	1	2	1	2	2	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:121957957C>T	uc003idq.1	-	4	1696	c.1169G>A	c.(1168-1170)AGA>AAA	p.R390K		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	390											0						CCCATCTCTTCTCACTTGGAT	0.433													28	47					0	0	0	0	T	121957957	T	T	121957957	3	4	289	1	0	0	0	0	1	0	0	0	2271	913	32	2	541	2	C4orf31	4	121957957	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	10493765	121957957	69196319	56	53625											
PCDH10	57575	broad.mit.edu	37	chr4	134084185	134084185	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaaagctctgggccactcaGatcggtgctggatgccttct	7	11	12	11	1	3	1	1	0	2	1	4	2	3	2	2	3	3	3	2	3	2	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:134084185G>T	uc003iha.2	+	4	3677	c.2851G>T	c.(2851-2853)GAT>TAT	p.D951Y		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	951	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GGGCCACTCAGATCGGTGCTG	0.488													19	42					6.33239e-15	8.307e-15	1	0	T	134084185	T	T	134084185	3	4	289	1	0	0	0	0	1	0	0	0	11561	942	33	2	2925	2	PCDH10	4	134084185	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	12126228	134084185	57070091	57	53626											
NR3C2	4306	broad.mit.edu	37	chr4	149035331	149035331	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagaattgttgggacacttaGttaccatcttcctcagttct	9	15	7	10	0	3	1	1	0	2	1	4	2	4	2	2	1	1	3	2	1	3	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:149035331G>A	uc003ilj.3	-	8	3057	c.2723C>T	c.(2722-2724)ACT>ATT	p.T908I	NR3C2_uc003ilk.3_Missense_Mutation_p.T791I|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	908	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GGGACACTTAGTTACCATCTT	0.473													6	12					0	0	0	0	A	149035331	A	A	149035331	3	1	289	1	0	0	0	0	1	0	0	0	10685	1029	36	4	239	4	NR3C2	4	149035331	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	14951146	149035331	42118945	58	53627											
ANP32C	23520	broad.mit.edu	37	chr4	165118636	165118636	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttttctgccaatacttcCaggccccctgagactcttag	8	12	6	15	0	2	1	0	1	2	1	3	2	3	1	4	1	2	0	4	1	3	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:165118636C>A	uc011cjk.1	-	1	228	c.228G>T	c.(226-228)CTG>CTT	p.L76L	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	76	LRR 2.										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		CCAATACTTCCAGGCCCCCTG	0.403													24	45					1.22574e-08	1.43788e-08	1	0	A	165118636	A	A	165118636	2	1	289	1	0	0	0	0	0	0	0	1	707	581	21	4		4	ANP32C	4	165118636	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	16083305	165118636	26035640	59	53628											
TUBB4Q	56604	broad.mit.edu	37	chr4	190903696	190903696	+	Frame_Shift_Del	DEL	G	-	-																															cctcatactcctcctccctcGgccgtggcatcctgatattg																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr4:190903696delG	uc011clg.1	-	4	1287	c.1284delC	c.(1282-1284)GCCfs	p.A428fs		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	429					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		CTCCTCCCTCGGCCGTGGCAT	0.537													---	---	---								-	190903696	-	-	190903696	7	5	289	1	0	1	0	1	0	0	0	0	16827	1103	39	0	20	0	TUBB4Q	4	190903696	Frame_Shift_Del	DEL	G	TCGA-DQ-7589-01A-11D-2229-08	25785060	190903696	250580	60	53629											
TRIO	7204	broad.mit.edu	37	chr5	14485341	14485341	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaaattttagaaaaccagcGcaattttttaaatggtaatg	16	13	6	6	1	0	1	0	0	0	1	0	1	0	1	2	1	2	2	2	1	8	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr5:14485341G>C	uc003jff.2	+	47	6827	c.6821G>C	c.(6820-6822)CGC>CCC	p.R2274P	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Missense_Mutation_p.R1923P	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2274					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GAAAACCAGCGCAATTTTTTA	0.398													20	74					0	0	0	0	C	14485341	C	C	14485341	3	2	289	1	0	0	0	0	1	0	0	0	16619	1087	38	3	7007	3	TRIO	5	14485341	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08		14485341	166429919	61	53630											
MARCH11	441061	broad.mit.edu	37	chr5	16067611	16067611	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tcactctcatcacaacctccCccgagctgttatcttctgat	8	13	4	16	1	5	1	3	1	3	0	7	2	6	1	3	0	2	2	3	0	2	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr5:16067611C>G	uc003jfo.2	-	4	1391	c.1178G>C	c.(1177-1179)GGG>GCG	p.G393A	MARCH11_uc010itw.1_Missense_Mutation_p.G149A	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	393						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						CACAACCTCCCCCGAGCTGTT	0.453													68	220					0	0	0	0	G	16067611	G	G	16067611	3	3	289	1	0	0	0	0	1	0	0	0	9353	623	22	4	34	4	MARCH11	5	16067611	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	1582270	16067611	164847649	62	53631											
PRDM9	56979	broad.mit.edu	37	chr5	23522816	23522816	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgcagtggacaaggggcaccCcaaccgttcagccctcagtc	9	6	11	15	1	2	0	2	0	0	0	3	1	2	1	4	3	3	3	4	3	2	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr5:23522816C>A	uc003jgo.2	+	8	886	c.704C>A	c.(703-705)CCC>CAC	p.P235H		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	235					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AAGGGGCACCCCAACCGTTCA	0.562										HNSCC(3;0.000094)			13	25					2.68362e-12	3.39276e-12	1	0	A	23522816	A	A	23522816	3	1	289	1	0	0	0	0	1	0	0	0	12525	623	22	4	730	4	PRDM9	5	23522816	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	7455205	23522816	157392444	63	53632											
PRDM9	56979	broad.mit.edu	37	chr5	23527008	23527008	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcaccagaggacacacacagGggagaagccctatgtctgca	13	5	11	12	0	2	2	1	0	1	2	2	4	2	3	2	3	2	1	2	3	2	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr5:23527008G>A	uc003jgo.2	+	11	1993	c.1811G>A	c.(1810-1812)GGG>GAG	p.G604E		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	604					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ACACACACAGGGGAGAAGCCC	0.602										HNSCC(3;0.000094)			36	93					0	0	0	0	A	23527008	A	A	23527008	3	1	289	1	0	0	0	0	1	0	0	0	12525	1232	43	4	1849	4	PRDM9	5	23527008	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	4192	23527008	157388252	64	53633											
CDH6	1004	broad.mit.edu	37	chr5	31323320	31323320	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggagtcagtgaccacggatGcagatcaagactatgattac	13	9	11	8	1	2	4	2	2	0	2	2	6	2	6	1	2	2	1	1	2	3	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr5:31323320G>T	uc003jhe.1	+	12	2604	c.2278G>T	c.(2278-2280)GCA>TCA	p.A760S		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	760	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						GACCACGGATGCAGATCAAGA	0.532													24	39					9.95505e-16	1.33463e-15	1	0	T	31323320	T	T	31323320	3	4	289	1	0	0	0	0	1	0	0	0	3129	1319	46	4	2320	4	CDH6	5	31323320	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	7796312	31323320	149591940	65	53634											
HEATR7B2	133558	broad.mit.edu	37	chr5	41004569	41004569	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttcacagacgacttcagtgCgagctaggtgatacaggcct	10	10	11	10	2	2	2	2	1	0	1	2	4	2	2	1	2	3	1	1	2	2	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr5:41004569C>A	uc003jmj.3	-	37	4563	c.4073G>T	c.(4072-4074)CGC>CTC	p.R1358L	HEATR7B2_uc003jmi.3_Missense_Mutation_p.R913L	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1358							binding			ovary(6)|central_nervous_system(2)	8						GACTTCAGTGCGAGCTAGGTG	0.408													11	18					0.000673444	0.000708277	1	0	A	41004569	A	A	41004569	3	1	289	1	0	0	0	0	1	0	0	0	7074	768	27	3	708	3	HEATR7B2	5	41004569	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	9681249	41004569	139910691	66	53635											
CEP120	153241	broad.mit.edu	37	chr5	122718431	122718431	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtaacatttaaaaagtaacCtgattttcaaatatatcttc	17	15	3	6	0	2	1	1	1	1	0	3	1	2	1	1	0	2	2	1	0	8	9			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr5:122718431C>A	uc003ktk.2	-	14	2095	c.2013G>T	c.(2011-2013)CAG>CAT	p.Q671H	CEP120_uc011cwq.1_Missense_Mutation_p.Q480H|CEP120_uc010jcz.1_Missense_Mutation_p.Q645H	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	671	Potential.					centrosome				ovary(1)	1						AAAAAGTAACCTGATTTTCAA	0.363													6	7					0.000157383	0.000168428	1	0	A	122718431	A	A	122718431	3	1	289	1	0	0	0	0	1	0	0	0	3261	695	24	4	979	4	CEP120	5	122718431	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	81713862	122718431	58196829	67	53636											
PCDHA1	56147	broad.mit.edu	37	chr5	140167837	140167837	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgctagtgaaggatcaCggtgagccggcgctgacagc	8	7	16	10	3	1	3	1	3	0	0	1	4	1	4	1	4	3	2	1	4	2	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr5:140167837C>A	uc003lhb.2	+	1	1962	c.1962C>A	c.(1960-1962)CAC>CAA	p.H654Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.H654Q	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	654	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAGGATCACGGTGAGCCGG	0.662													30	45					8.88839e-20	1.21841e-19	1	0	A	140167837	A	A	140167837	3	1	289	1	0	0	0	0	1	0	0	0	11573	535	19	3	1964	3	PCDHA1	5	140167837	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	17449406	140167837	40747423	68	53637											
JAKMIP2	9832	broad.mit.edu	37	chr5	147012302	147012303	+	In_Frame_Ins	INS	-	TTG	TTG																															tctctggcgtcctgtagttcINSttgttgtaaccggtgatttt																								rs3763095	byFrequency	TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr5:147012302_147012303insTTG	uc003loq.1	-	13	2098_2099	c.1716_1717insCAA	c.(1714-1719)insCAA	p.572_573insQ	JAKMIP2_uc011dbx.1_In_Frame_Ins_p.530_531insQ|JAKMIP2_uc003lor.1_In_Frame_Ins_p.551_552insQ|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_In_Frame_Ins_p.572_573insQ	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	572_573	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTGTAGTTCTTGTTGTAACC	0.371													---	---	---								TTG	147012303	TTG	TTG	147012302	7	5	289	1	0	1	1	0	0	0	0	0	7980	922	32	0	751	0	JAKMIP2	5	147012302	In_Frame_Ins	INS	-	TCGA-DQ-7589-01A-11D-2229-08	6844465	147012302	33902958	69	53638											
NEDD9	4739	broad.mit.edu	37	chr6	11192580	11192580	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgtagtcactcactcacccCttttgtaggcgggatgtcat	7	14	9	11	1	4	0	4	0	0	0	4	1	4	1	2	2	0	2	2	2	2	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:11192580C>G	uc003mzv.2	-	4	828	c.661G>C	c.(661-663)GGG>CGG	p.G221R	NEDD9_uc010joz.2_Missense_Mutation_p.G221R|NEDD9_uc003mzw.3_Missense_Mutation_p.G75R	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	221	Interacts strongly with spindle- regulatory protein D1M1.				actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			TCACTCACCCCTTTTGTAGGC	0.517													10	14					0	0	0	0	G	11192580	G	G	11192580	3	3	289	1	0	0	0	0	1	0	0	0	10367	681	24	4	1859	4	NEDD9	6	11192580	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08		11192580	159922487	70	53639											
PGBD1	84547	broad.mit.edu	37	chr6	28269300	28269300	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaatgctttgatagtgacCaattcctgaatggaaagcct	12	12	10	7	0	0	4	0	4	0	0	1	5	1	5	3	1	2	1	3	1	5	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:28269300C>G	uc003nky.2	+	7	2039	c.1669C>G	c.(1669-1671)CAA>GAA	p.Q557E	PGBD1_uc003nkz.2_Missense_Mutation_p.Q557E	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	557					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						TGATAGTGACCAATTCCTGAA	0.363													17	47					0	0	0	0	G	28269300	G	G	28269300	3	3	289	1	0	0	0	0	1	0	0	0	11835	595	21	4	1691	4	PGBD1	6	28269300	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	17076720	28269300	142845767	71	53640											
KIAA1949	170954	broad.mit.edu	37	chr6	30647078	30647078	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggggcactggggacctcaGgctccgggcccagctcctcc	4	6	15	16	1	1	0	1	0	0	0	4	1	4	1	5	6	1	3	5	6	0	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:30647078G>C	uc003nra.2	-	3	1931	c.1700C>G	c.(1699-1701)CCT>CGT	p.P567R	KIAA1949_uc003nrb.3_Missense_Mutation_p.P567R	NM_001134870	NP_001128342	Q6NYC8	PHTNS_HUMAN	phostensin	567						cytoplasm|cytoskeleton	actin binding				0						GGGGACCTCAGGCTCCGGGCC	0.637													22	19					0	0	0	0	C	30647078	C	C	30647078	3	2	289	1	0	0	0	0	1	0	0	0	8302	1000	35	4	149	4	KIAA1949	6	30647078	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	2377778	30647078	140467989	72	53641											
DLK2	65989	broad.mit.edu	37	chr6	43418549	43418549	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agcctcttgcctccgcaccaCctccttcactgagatccgca	7	9	6	19	2	2	1	1	1	1	1	5	2	5	1	7	0	2	2	7	0	0	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:43418549C>G	uc003ova.2	-	6	1089	c.880G>C	c.(880-882)GTG>CTG	p.V294L	DLK2_uc003ovb.2_Missense_Mutation_p.V294L	NM_023932	NP_076421	Q6UY11	DLK2_HUMAN	EGF-like-domain, multiple 9 precursor	294	Extracellular (Potential).					integral to membrane	calcium ion binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CTCCGCACCACCTCCTTCACT	0.657													47	130					0	0	0	0	G	43418549	G	G	43418549	3	3	289	1	0	0	0	0	1	0	0	0	4587	507	18	4	275	4	DLK2	6	43418549	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	12771471	43418549	127696518	73	53642											
ENPP4	22875	broad.mit.edu	37	chr6	46108910	46108910	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgaattcagcccattattttGgttgccgatgaaggctggac	9	12	11	9	2	1	1	1	1	0	0	1	4	1	2	2	3	2	2	2	3	3	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:46108910G>T	uc003oxy.2	+	3	1207	c.948G>T	c.(946-948)TTG>TTT	p.L316F		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	316	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						CCATTATTTTGGTTGCCGATG	0.333													11	47					4.36969e-10	5.22649e-10	1	0	T	46108910	T	T	46108910	3	4	289	1	0	0	0	0	1	0	0	0	5156	1339	47	4	954	4	ENPP4	6	46108910	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	2690361	46108910	125006157	74	53643											
RHAG	6005	broad.mit.edu	37	chr6	49587000	49587000	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtaggttgatacccacactgCtgaagccatatttcttcagg	10	12	9	10	0	2	2	1	2	1	0	2	2	2	2	2	2	3	3	2	2	4	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:49587000C>A	uc003ozk.3	-	2	295	c.233G>T	c.(232-234)AGC>ATC	p.S78I	RHAG_uc010jzl.2_Missense_Mutation_p.S78I|RHAG_uc010jzm.2_Missense_Mutation_p.S78I	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	78	Cytoplasmic (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					ACCCACACTGCTGAAGCCATA	0.438													22	54					5.35356e-11	6.6308e-11	1	0	A	49587000	A	A	49587000	3	1	289	1	0	0	0	0	1	0	0	0	13380	797	28	4	1032	4	RHAG	6	49587000	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	3478090	49587000	121528067	75	53644											
PKHD1	5314	broad.mit.edu	37	chr6	51923189	51923189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtaggtaagtggtgaccaCatcaggattcagccaggtgt	10	9	13	9	1	2	1	2	1	0	0	2	2	2	2	3	4	1	2	3	4	2	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:51923189C>T	uc003pah.1	-	16	1720	c.1444G>A	c.(1444-1446)GTG>ATG	p.V482M	PKHD1_uc003pai.2_Missense_Mutation_p.V482M	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	482	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GTGGTGACCACATCAGGATTC	0.547													47	96					0	0	0	0	T	51923189	T	T	51923189	3	4	289	1	0	0	0	0	1	0	0	0	12026	478	17	4	11027	4	PKHD1	6	51923189	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	2336189	51923189	119191878	76	53645											
IMPG1	3617	broad.mit.edu	37	chr6	76751702	76751702	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgttgggaaaaatgcggatCtttttgttcgatgctttgcc	7	15	11	8	3	1	0	0	0	1	0	2	3	1	2	2	2	3	3	2	2	2	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:76751702C>A	uc003pik.1	-	2	339	c.209G>T	c.(208-210)AGA>ATA	p.R70I		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	70					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AAATGCGGATCTTTTTGTTCG	0.373													34	32					8.16277e-20	1.12526e-19	1	0	A	76751702	A	A	76751702	3	1	289	1	0	0	0	0	1	0	0	0	7767	913	32	2	2248	2	IMPG1	6	76751702	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	24828513	76751702	94363365	77	53646											
SOBP	55084	broad.mit.edu	37	chr6	107955647	107955647	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taccccgtgatcgtgcccctAccggtgcccatccccatccc	5	8	7	21	3	0	1	0	1	0	0	3	1	2	1	9	1	4	0	9	1	2	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:107955647A>T	uc003prx.2	+	6	2103	c.1599A>T	c.(1597-1599)CTA>CTT	p.L533L		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	533	Pro-rich.						metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		TCGTGCCCCTACCGGTGCCCA	0.667													16	22					0	0	0	0	T	107955647	T	T	107955647	2	4	289	1	0	0	0	0	0	0	0	1	14976	378	14	5		5	SOBP	6	107955647	Silent	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	31203945	107955647	63159420	78	53647											
REV3L	5980	broad.mit.edu	37	chr6	111714134	111714134	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcagcaagagaatttcctgAtaaatgattcttgcaggatc	14	12	8	7	0	2	3	1	2	1	1	4	5	3	4	1	1	2	2	1	1	4	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:111714134A>G	uc003puy.3	-	5	930	c.607T>C	c.(607-609)TCA>CCA	p.S203P	REV3L_uc003pux.3_Missense_Mutation_p.S125P|REV3L_uc003puz.3_Missense_Mutation_p.S125P	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	203					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GAATTTCCTGATAAATGATTC	0.294								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					21	15					0	0	0	0	G	111714134	G	G	111714134	3	3	289	1	0	0	0	0	1	0	0	0	13305	333	12	5	8897	5	REV3L	6	111714134	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	3758487	111714134	59400933	79	53648											
HIVEP2	3097	broad.mit.edu	37	chr6	143090889	143090889	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aaccgaggatttgaaggtggCctgttgcacataattgggtt	10	12	13	6	1	0	1	0	1	0	0	0	3	0	2	2	4	2	3	2	4	3	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:143090889C>T	uc003qjd.2	-	5	5730	c.4987G>A	c.(4987-4989)GCC>ACC	p.A1663T		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1663					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TTGAAGGTGGCCTGTTGCACA	0.463													32	45					0	0	0	0	T	143090889	T	T	143090889	3	4	289	1	0	0	0	0	1	0	0	0	7226	739	26	4	2377	4	HIVEP2	6	143090889	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	31376755	143090889	28024178	80	53649											
UTRN	7402	broad.mit.edu	37	chr6	145142116	145142116	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccctcgacttggttacctGcctgtccagacagttcttga	7	12	8	14	1	1	2	0	1	1	1	3	3	2	2	4	1	2	2	4	1	1	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:145142116G>A	uc003qkt.2	+	65	9548	c.9456G>A	c.(9454-9456)CTG>CTA	p.L3152L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	3152	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TTGGTTACCTGCCTGTCCAGA	0.378													34	48					0	0	0	0	A	145142116	A	A	145142116	2	1	289	1	0	0	0	0	0	0	0	1	17171	1306	46	4		4	UTRN	6	145142116	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	2051227	145142116	25972951	81	53650											
ARID1B	57492	broad.mit.edu	37	chr6	157100355	157100355	+	Frame_Shift_Del	DEL	G	-	-																															ctcgcccagccccatgatgcGgagctacggcggcagctacc																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:157100355delG	uc003qqn.2	+	1	1270	c.1118delG	c.(1117-1119)CGGfs	p.R373fs	ARID1B_uc003qqo.2_Frame_Shift_Del_p.R373fs|ARID1B_uc003qqp.2_Frame_Shift_Del_p.R373fs	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	431	Ala-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCCATGATGCGGAGCTACGGC	0.597													---	---	---								-	157100355	-	-	157100355	7	5	289	1	0	1	0	1	0	0	0	0	914	1116	39	0	1294	0	ARID1B	6	157100355	Frame_Shift_Del	DEL	G	TCGA-DQ-7589-01A-11D-2229-08	11958239	157100355	14014712	82	53651											
SNX9	51429	broad.mit.edu	37	chr6	158359775	158359775	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcatcatgtcttacgcgttGcaaggtaagatgaaagggtc	12	10	12	7	2	2	2	1	1	1	1	3	2	2	2	0	2	3	4	0	2	4	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr6:158359775G>A	uc003qqv.1	+	16	1817	c.1644G>A	c.(1642-1644)TTG>TTA	p.L548L		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	548	BAR.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		CTTACGCGTTGCAAGGTAAGA	0.413													83	126					0	0	0	0	A	158359775	A	A	158359775	2	1	289	1	0	0	0	0	0	0	0	1	14973	1310	46	4		4	SNX9	6	158359775	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	1259420	158359775	12755292	83	53652											
TMEM195	392636	broad.mit.edu	37	chr7	15240953	15240953	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gttgtttcatgcttctaactCcccagaaagcaatgcaaatg	12	12	7	10	0	2	1	1	0	1	1	3	1	3	1	2	0	4	5	2	0	4	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:15240953C>A	uc003stb.1	-	13	1465	c.1295G>T	c.(1294-1296)GGA>GTA	p.G432V		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	432	Helical; (Potential).				ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						GCTTCTAACTCCCCAGAAAGC	0.323													21	34					1.55811e-20	2.17245e-20	1	0	A	15240953	A	A	15240953	3	1	289	1	0	0	0	0	1	0	0	0	16183	855	30	2	46	2	TMEM195	7	15240953	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08		15240953	143897710	84	53653											
RAPGEF5	9771	broad.mit.edu	37	chr7	22233539	22233539	+	5'Flank	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggaaactctcacctccaaTggctctccgcactcccagct	9	8	7	17	1	2	0	1	0	2	0	6	1	4	1	4	2	2	3	4	2	2	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:22233539T>A	uc011jym.1	-						RAPGEF5_uc003svg.2_Missense_Mutation_p.H217L			Q92565	RPGF5_HUMAN	Synthetic construct DNA, clone: pF1KSDA0277, Homo sapiens RAPGEF5 gene for Rap guanine nucleotide exchange factor 5, complete cds, without stop codon, in Flexi system.						nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						TCACCTCCAATGGCTCTCCGC	0.418													65	266					0	0	0	0	A	22233539	A	A	22233539	1	1	289	0	1	0	0	0	0	0	0	0	13112	1464	51	5		5	RAPGEF5	7	22233539	5'Flank	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	6992586	22233539	136905124	85	53654											
GHRHR	2692	broad.mit.edu	37	chr7	31013712	31013712	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctggcctccacctcccccaGctcaaggagagccttctggt	6	8	9	18	0	2	1	1	0	1	1	4	2	4	1	7	3	2	1	7	3	1	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:31013712G>T	uc003tbx.2	+	7	758	c.710G>T	c.(709-711)AGC>ATC	p.S237I	GHRHR_uc003tbw.1_Missense_Mutation_p.S237I|GHRHR_uc003tby.2_Missense_Mutation_p.S173I|GHRHR_uc003tbz.2_Intron	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	237	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	ACCTCCCCCAGCTCAAGGAGA	0.637													65	92					2.10938e-32	3.0455e-32	1	0	T	31013712	T	T	31013712	3	4	289	1	0	0	0	0	1	0	0	0	6410	971	34	4	736	4	GHRHR	7	31013712	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	8780173	31013712	128124951	86	53655											
WBSCR17	64409	broad.mit.edu	37	chr7	70800594	70800594	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcggggtaaagggggcctTccggctactctttccccggc	4	8	16	13	3	1	0	0	0	1	0	3	0	3	0	4	7	1	2	4	7	3	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:70800594T>C	uc003tvy.2	+	2	297	c.297T>C	c.(295-297)CTT>CTC	p.L99L	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	99	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				AAGGGGGCCTTCCGGCTACTC	0.458													14	41					0	0	0	0	C	70800594	C	C	70800594	2	2	289	1	0	0	0	0	0	0	0	1	17332	1770	62	5		5	WBSCR17	7	70800594	Silent	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	39786882	70800594	88338069	87	53656											
SEMA3E	9723	broad.mit.edu	37	chr7	82997282	82997282	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtctggcaaaaataggtccCagcatctgatttgtgtaacc	11	12	9	9	0	2	1	0	1	2	0	3	1	3	1	2	2	2	3	2	2	4	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:82997282C>A	uc003uhy.1	-	17	2414	c.1948G>T	c.(1948-1950)GGG>TGG	p.G650W		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	650	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				AAATAGGTCCCAGCATCTGAT	0.418													28	105					3.90053e-15	5.14448e-15	1	0	A	82997282	A	A	82997282	3	1	289	1	0	0	0	0	1	0	0	0	14093	594	21	4	383	4	SEMA3E	7	82997282	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	12196688	82997282	76141381	88	53657											
MGC26647	219557	broad.mit.edu	37	chr7	88423573	88423574	+	Missense_Mutation	DNP	TG	GT	GT																															ctattatacatgtttataaaTgttgccgggtccatgaattc																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:88423573_88423574TG>GT	uc003ujv.2	-	2	865_866	c.683_684CA>AC	c.(682-684)ACA>AAC	p.T228N	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	228											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			TGTTTATAAATGTTGCCGGGTC	0.45													20	49					0	0	0	0	GT	88423574	GT	GT	88423573	3	3	289	1	0	0	0	0	1	0	0	0	9603	1451	51	5	81	5	MGC26647	7	88423573	Missense_Mutation	DNP	TG	TCGA-DQ-7589-01A-11D-2229-08	5426291	88423573	70715090	89	53658											
ZNF804B	219578	broad.mit.edu	37	chr7	88965792	88965792	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agatcctacagctacaagccCagcagcatatgcagaagcaa	16	5	8	12	0	0	2	0	0	0	2	1	2	1	2	2	0	8	5	2	0	6	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:88965792C>A	uc011khi.1	+	4	4034	c.3496C>A	c.(3496-3498)CAG>AAG	p.Q1166K		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1166						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GCTACAAGCCCAGCAGCATAT	0.448										HNSCC(36;0.09)			18	42					1.02788e-11	1.2928e-11	1	0	A	88965792	A	A	88965792	3	1	289	1	0	0	0	0	1	0	0	0	18238	595	21	4	3510	4	ZNF804B	7	88965792	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	542219	88965792	70172871	90	53659											
C7orf63	79846	broad.mit.edu	37	chr7	89887457	89887457	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatttgtcaagaaactggtaCagtgttatcagaatggactt	14	13	9	5	0	2	2	2	0	0	2	2	3	2	3	0	2	2	2	0	2	6	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:89887457C>T	uc010lep.2	+	3	477	c.226C>T	c.(226-228)CAG>TAG	p.Q76*	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_5'UTR|C7orf63_uc011khj.1_Nonsense_Mutation_p.Q76*|C7orf63_uc010leo.2_Nonsense_Mutation_p.Q76*	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	76							binding			ovary(1)	1						GAAACTGGTACAGTGTTATCA	0.259													27	41					0	0	0	0	T	89887457	T	T	89887457	4	4	289	1	0	0	0	0	0	1	0	0	2420	479	17	4	236	4	C7orf63	7	89887457	Nonsense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	921665	89887457	69251206	91	53660											
PON1	5444	broad.mit.edu	37	chr7	94944721	94944721	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccccaattccaacactgttgGatcttcttcattcaggtcca	9	13	5	14	0	4	0	2	0	2	0	6	1	6	1	4	2	1	1	4	2	2	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:94944721G>T	uc003uns.2	-	4	380	c.283C>A	c.(283-285)CCA>ACA	p.P95T	PON1_uc011kih.1_Missense_Mutation_p.P95T	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	95					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	AACACTGTTGGATCTTCTTCA	0.383													14	57					1.49906e-05	1.66259e-05	1	0	T	94944721	T	T	94944721	3	4	289	1	0	0	0	0	1	0	0	0	12303	1174	41	2	808	2	PON1	7	94944721	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	5057264	94944721	64193942	92	53661											
PON2	5445	broad.mit.edu	37	chr7	95039293	95039295	+	In_Frame_Del	DEL	AAC	-	-																															acttcatttggactgtagtaAacaacatttgcccagtgtaa																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:95039293_95039295delAAC	uc003unv.2	-	6	734_736	c.613_615delGTT	c.(613-615)GTTdel	p.V205del	PON2_uc003unu.2_In_Frame_Del_p.V193del|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_In_Frame_Del_p.V118del	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	205					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			GACTGTAGTAAACAACATTTGCC	0.369													---	---	---								-	95039295	-	-	95039293	7	5	289	1	0	1	0	1	0	0	0	0	12304	1	1	0	465	0	PON2	7	95039293	In_Frame_Del	DEL	AAC	TCGA-DQ-7589-01A-11D-2229-08	94572	95039293	64099370	93	53662											
SLC12A9	56996	broad.mit.edu	37	chr7	100459152	100459152	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggctgccctgctcaccgcGcgaggaggccccagtagctg	5	6	14	16	3	1	0	1	0	0	0	1	2	1	1	4	3	3	4	4	3	1	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:100459152G>T	uc003uwp.2	+	11	1624	c.1482G>T	c.(1480-1482)GCG>GCT	p.A494A	SLC12A9_uc003uwq.2_Silent_p.A405A|SLC12A9_uc011kki.1_Silent_p.A25A|SLC12A9_uc003uwr.2_Silent_p.A230A|SLC12A9_uc003uws.2_Silent_p.A25A|SLC12A9_uc003uwt.2_Silent_p.A230A|SLC12A9_uc003uwv.2_Silent_p.A25A	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	494	Extracellular (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					TGCTCACCGCGCGAGGAGGCC	0.652													41	91					9.85913e-13	1.26612e-12	1	0	T	100459152	T	T	100459152	2	4	289	1	0	0	0	0	0	0	0	1	14455	1074	38	3		3	SLC12A9	7	100459152	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	5419859	100459152	58679511	94	53663											
SLC26A5	375611	broad.mit.edu	37	chr7	103018200	103018200	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggatattttacttcaccaTcctcttcttcaggcttggta	7	16	8	10	0	4	0	2	0	2	0	5	1	5	1	2	4	1	2	2	4	3	8			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:103018200T>A	uc003vbz.2	-	18	2068	c.1832A>T	c.(1831-1833)GAT>GTT	p.D611V	SLC26A5_uc003vbt.1_Missense_Mutation_p.D611V|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.D579V|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	611	Cytoplasmic (Potential).|STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TACTTCACCATCCTCTTCTTC	0.408													31	114					0	0	0	0	A	103018200	A	A	103018200	3	1	289	1	0	0	0	0	1	0	0	0	14584	1435	50	5	455	5	SLC26A5	7	103018200	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	2559048	103018200	56120463	95	53664											
LMOD2	442721	broad.mit.edu	37	chr7	123302930	123302930	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccccctcctcctcctccTccccctccttcttcccaaag	3	11	1	26	0	1	0	0	0	1	0	9	0	9	0	11	0	0	0	11	0	1	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:123302930T>C	uc003vky.2	+	2	1447	c.1290T>C	c.(1288-1290)CCT>CCC	p.P430P		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	430	Pro-rich.					cytoskeleton	actin binding|tropomyosin binding				0						ctcctcctcctccccctcctt	0.294													2	2					0	0	0	0	C	123302930	C	C	123302930	2	2	289	1	0	0	0	0	0	0	0	1	8899	1538	54	5		5	LMOD2	7	123302930	Silent	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	20284730	123302930	35835733	96	53665											
DGKI	9162	broad.mit.edu	37	chr7	137128844	137128844	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	atgatcttctgaagagactgGtgacctaaaaggaaataata	17	10	9	5	0	2	4	0	3	2	1	2	6	2	5	1	2	0	0	1	2	6	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:137128844G>A	uc003vtt.2	-	29	2765	c.2764C>T	c.(2764-2766)CCA>TCA	p.P922S	DGKI_uc003vtu.2_Missense_Mutation_p.P591S	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	922					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GAAGAGACTGGTGACCTAAAA	0.299													14	15					0	0	0	0	A	137128844	A	A	137128844	3	1	289	1	0	0	0	0	1	0	0	0	4493	1261	44	4	457	4	DGKI	7	137128844	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	13825914	137128844	22009819	97	53666											
GIMAP8	155038	broad.mit.edu	37	chr7	150171132	150171132	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcagctgcagtccacaggaCccgagcagaatccggggaca	11	3	14	13	2	0	1	0	0	0	1	2	4	2	3	3	4	3	4	3	4	1	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr7:150171132C>T	uc003whj.2	+	4	1045	c.715C>T	c.(715-717)CCC>TCC	p.P239S		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	239						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GTCCACAGGACCCGAGCAGAA	0.552													25	99					0	0	0	0	T	150171132	T	T	150171132	3	4	289	1	0	0	0	0	1	0	0	0	6422	507	18	4	725	4	GIMAP8	7	150171132	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	13042288	150171132	8967531	98	53667											
SGK223	157285	broad.mit.edu	37	chr8	8176380	8176380	+	Frame_Shift_Del	DEL	C	-	-																															aggcgcggcggcggcgggggCgggagccggggcgggggcgg																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:8176380delC	uc003wsh.3	-	5	3505	c.3505delG	c.(3505-3507)GCCfs	p.A1169fs		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	1169	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity				0						gcggcgggggcgggagccggg	0.622													---	---	---								-	8176380	-	-	8176380	7	5	289	1	0	1	0	1	0	0	0	0	14275	768	27	0	707	0	SGK223	8	8176380	Frame_Shift_Del	DEL	C	TCGA-DQ-7589-01A-11D-2229-08		8176380	138187642	99	53668											
DOCK5	80005	broad.mit.edu	37	chr8	25174610	25174610	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaaagaatgtggaggtgaCgatgtctgtgcacgatgagg	11	8	16	6	2	1	3	0	2	1	1	1	6	1	4	1	3	1	1	1	3	2	0	rs61732769	byFrequency	TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:25174610C>T	uc003xeg.2	+	14	1543	c.1406C>T	c.(1405-1407)ACG>ATG	p.T469M	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.T183M|DOCK5_uc003xei.2_Missense_Mutation_p.T39M	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	469	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GTGGAGGTGACGATGTCTGTG	0.498													39	191					0	0	0	0	T	25174610	T	T	25174610	3	4	289	1	0	0	0	0	1	0	0	0	4712	536	19	1	1460	1	DOCK5	8	25174610	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	16998230	25174610	121189412	100	53669											
KIF13B	23303	broad.mit.edu	37	chr8	28929820	28929820	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccagcacgtcagggcccAtctccggctgagcctgcagc	7	5	12	17	2	2	1	1	1	1	0	3	1	2	1	4	2	4	4	4	2	0	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:28929820A>C	uc003xhh.3	-	39	4594	c.4535T>G	c.(4534-4536)ATG>AGG	p.M1512R	KIF13B_uc011laz.1_Missense_Mutation_p.M31R	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1512					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		GTCAGGGCCCATCTCCGGCTG	0.587													3	7					0	0	0	0	C	28929820	C	C	28929820	3	2	289	1	0	0	0	0	1	0	0	0	8314	217	8	5	953	5	KIF13B	8	28929820	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	3755210	28929820	117434202	101	53670											
ASH2L	9070	broad.mit.edu	37	chr8	37996387	37996387	+	Frame_Shift_Del	DEL	C	-	-																															cctccgaaggatctcacttaCcgccctgtgagtaacattac																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:37996387delC	uc003xkt.3	+	15	1831	c.1773delC	c.(1771-1773)TACfs	p.Y591fs	ASH2L_uc011lbk.1_Frame_Shift_Del_p.Y452fs|ASH2L_uc003xku.3_Frame_Shift_Del_p.Y497fs|ASH2L_uc010lwa.2_Frame_Shift_Del_p.Y464fs	NM_004674	NP_004665	Q9UBL3	ASH2L_HUMAN	ash2-like isoform a	591					hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				ATCTCACTTACCGCCCTGTGA	0.453													---	---	---								-	37996387	-	-	37996387	7	5	289	1	0	1	0	1	0	0	0	0	1044	518	18	0	1831	0	ASH2L	8	37996387	Frame_Shift_Del	DEL	C	TCGA-DQ-7589-01A-11D-2229-08	9066567	37996387	108367635	102	53671											
XKR4	114786	broad.mit.edu	37	chr8	56435942	56435942	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagaagcccatcagctacaTggccgtcatcatccagttct	11	9	7	14	1	4	1	3	0	1	1	5	1	5	1	3	1	3	2	3	1	3	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:56435942T>C	uc003xsf.2	+	3	1141	c.1109T>C	c.(1108-1110)ATG>ACG	p.M370T		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	370	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			ATCAGCTACATGGCCGTCATC	0.587													35	55					0	0	0	0	C	56435942	C	C	56435942	3	2	289	1	0	0	0	0	1	0	0	0	17501	1464	51	5	1119	5	XKR4	8	56435942	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	18439555	56435942	89928080	103	53672											
XKR4	114786	broad.mit.edu	37	chr8	56436416	56436416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtcaccaagttgtgcttGtgaggacccagccgctgcct	7	9	12	13	1	1	1	1	1	0	0	1	2	1	2	4	1	3	4	4	1	1	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:56436416G>A	uc003xsf.2	+	3	1615	c.1583G>A	c.(1582-1584)TGT>TAT	p.C528Y		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	528						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			AGTTGTGCTTGTGAGGACCCA	0.532													28	89					0	0	0	0	A	56436416	A	A	56436416	3	1	289	1	0	0	0	0	1	0	0	0	17501	1377	48	4	1593	4	XKR4	8	56436416	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	474	56436416	89927606	104	53673											
ASPH	444	broad.mit.edu	37	chr8	62475423	62475423	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aatctctgcagggtaagcagGgaacctctcatatgacctga	12	9	10	10	0	2	2	1	2	2	0	4	3	2	3	2	2	3	3	2	2	4	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:62475423G>A	uc003xuj.2	-	18	1586	c.1317C>T	c.(1315-1317)TCC>TCT	p.S439S	ASPH_uc011leg.1_Silent_p.S410S|ASPH_uc003xuo.2_Silent_p.S420S	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	439	Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	GGGTAAGCAGGGAACCTCTCA	0.358													28	48					0	0	0	0	A	62475423	A	A	62475423	2	1	289	1	0	0	0	0	0	0	0	1	1055	1219	43	4		4	ASPH	8	62475423	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	6039007	62475423	83888599	105	53674											
SULF1	23213	broad.mit.edu	37	chr8	70488375	70488375	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acaacgagaactgctcttccCcctcgtggcaggccatgcat	9	8	9	15	2	1	1	0	0	1	1	3	2	2	1	3	2	4	3	3	2	2	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:70488375C>T	uc010lza.1	+	6	1060	c.343C>T	c.(343-345)CCC>TCC	p.P115S	SULF1_uc003xyd.2_Missense_Mutation_p.P115S|SULF1_uc003xye.2_Missense_Mutation_p.P115S|SULF1_uc003xyf.2_Missense_Mutation_p.P115S|SULF1_uc003xyg.2_Missense_Mutation_p.P115S	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	115					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CTGCTCTTCCCCCTCGTGGCA	0.517													22	40					0	0	0	0	T	70488375	T	T	70488375	3	4	289	1	0	0	0	0	1	0	0	0	15436	623	22	4	349	4	SULF1	8	70488375	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	8012952	70488375	75875647	106	53675											
KCNB2	9312	broad.mit.edu	37	chr8	73849810	73849810	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaggccactgccagtcacCacagctgacttttcgctcac	8	8	8	17	1	2	1	2	1	0	0	3	1	2	1	4	1	2	2	4	1	0	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:73849810C>T	uc003xzb.2	+	3	2808	c.2220C>T	c.(2218-2220)ACC>ACT	p.T740T		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	740	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TGCCAGTCACCACAGCTGACT	0.552													95	248					0	0	0	0	T	73849810	T	T	73849810	2	4	289	1	0	0	0	0	0	0	0	1	8052	581	21	4		4	KCNB2	8	73849810	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	3361435	73849810	72514212	107	53676											
MRPS28	28957	broad.mit.edu	37	chr8	80942288	80942288	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caccttctgtaggggctccaCcttctgtagaagctccgagt	7	11	10	13	1	2	1	0	0	2	1	4	2	4	1	4	2	1	4	4	2	3	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:80942288C>T	uc003ybp.2	-	1	219	c.196G>A	c.(196-198)GTG>ATG	p.V66M	MRPS28_uc003ybo.2_Intron|TPD52_uc010lzr.2_Intron	NM_014018	NP_054737	Q9Y2Q9	RT28_HUMAN	mitochondrial ribosomal protein S28	66						mitochondrial small ribosomal subunit					0	Lung NSC(7;1.86e-06)|all_lung(9;6.91e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00769)|Epithelial(68;0.0208)|all cancers(69;0.0805)			AGGGGCTCCACCTTCTGTAGA	0.652													10	27					0	0	0	0	T	80942288	T	T	80942288	3	4	289	1	0	0	0	0	1	0	0	0	9892	507	18	4	379	4	MRPS28	8	80942288	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	7092478	80942288	65421734	108	53677											
CSMD3	114788	broad.mit.edu	37	chr8	114111059	114111059	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttgaaaatcagtaaatatGagtgaaattgtgtccccagg	15	12	9	5	0	1	3	1	3	0	0	2	3	2	3	2	1	0	1	2	1	6	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:114111059G>C	uc003ynu.2	-	5	1002	c.843C>G	c.(841-843)CTC>CTG	p.L281L	CSMD3_uc003ynt.2_Silent_p.L241L|CSMD3_uc011lhx.1_Silent_p.L281L|CSMD3_uc010mcx.1_Silent_p.L281L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	281	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CAGTAAATATGAGTGAAATTG	0.383										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	44					0	0	0	0	C	114111059	C	C	114111059	2	2	289	1	0	0	0	0	0	0	0	1	3963	1277	45	2		2	CSMD3	8	114111059	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	33168771	114111059	32252963	109	53678											
CSMD3	114788	broad.mit.edu	37	chr8	114290843	114290843	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgtaatataccttaaatccAtgagcactaactgcaaaatc	16	11	4	10	1	0	1	0	1	0	0	3	1	1	1	2	0	4	3	2	0	8	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:114290843A>T	uc003ynu.2	-	3	651	c.492T>A	c.(490-492)CAT>CAA	p.H164Q	CSMD3_uc003ynt.2_Missense_Mutation_p.H124Q|CSMD3_uc011lhx.1_Missense_Mutation_p.H164Q|CSMD3_uc010mcx.1_Missense_Mutation_p.H164Q	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	164	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCTTAAATCCATGAGCACTAA	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	56					0	0	0	0	T	114290843	T	T	114290843	3	4	289	1	0	0	0	0	1	0	0	0	3963	214	8	5	10907	5	CSMD3	8	114290843	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	179784	114290843	32073179	110	53679											
ZHX1	11244	broad.mit.edu	37	chr8	124265876	124265876	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttatgagtgatggtccccTgtcccagttgttaattcttt	6	19	8	8	0	1	2	0	2	1	0	3	2	3	2	3	1	0	2	3	1	2	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr8:124265876T>C	uc003yqe.2	-	3	2741	c.2311A>G	c.(2311-2313)AGG>GGG	p.R771G	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.R771G|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.R771G	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	771					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			GATGGTCCCCTGTCCCAGTTG	0.453													92	136					0	0	0	0	C	124265876	C	C	124265876	3	2	289	1	0	0	0	0	1	0	0	0	17742	1579	55	5	314	5	ZHX1	8	124265876	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	9975033	124265876	22098146	111	53680											
ZCCHC7	84186	broad.mit.edu	37	chr9	37356934	37356934	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaggaagggccgtgcctcatGgaaaagcaacaggtggcctc	12	5	14	10	1	1	0	1	0	0	0	2	2	1	2	3	5	3	1	3	5	5	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr9:37356934G>A	uc003zzq.2	+	9	1474	c.1301G>A	c.(1300-1302)TGG>TAG	p.W434*	ZCCHC7_uc011lqh.1_Nonsense_Mutation_p.W144*|ZCCHC7_uc011lqi.1_Nonsense_Mutation_p.W433*|ZCCHC7_uc010mlt.2_Nonsense_Mutation_p.W433*	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	434							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)		CGTGCCTCATGGAAAAGCAAC	0.433													18	8					0	0	0	0	A	37356934	A	A	37356934	4	1	289	1	0	0	0	0	0	1	0	0	17660	1357	47	4	1331	4	ZCCHC7	9	37356934	Nonsense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08		37356934	103856497	112	53681											
COL15A1	1306	broad.mit.edu	37	chr9	101798616	101798616	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaagggggatggatggaGccagtattgtgggaccccct	10	7	17	7	0	0	1	0	0	0	1	0	6	0	5	3	5	1	1	3	5	2	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr9:101798616G>T	uc004azb.1	+	21	2553	c.2347G>T	c.(2347-2349)GCC>TCC	p.A783S		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	783	Triple-helical region 3 (COL3).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				GATGGATGGAGCCAGTATTGT	0.507													63	26					2.09386e-48	3.09638e-48	1	0	T	101798616	T	T	101798616	3	4	289	1	0	0	0	0	1	0	0	0	3687	971	34	4	2429	4	COL15A1	9	101798616	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	64441682	101798616	39414815	113	53682											
SLC2A6	11182	broad.mit.edu	37	chr9	136339125	136339125	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agacgaagagcagcaccttgCggcctgcgaggtccatggtg	9	6	15	11	3	0	2	0	0	0	2	1	4	1	2	3	3	4	2	3	3	1	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr9:136339125C>T	uc004cee.2	-	7	1108	c.1013G>A	c.(1012-1014)CGC>CAC	p.R338H	SLC2A6_uc004cef.2_Missense_Mutation_p.R338H|SLC2A6_uc004ceg.2_Missense_Mutation_p.R315H	NM_017585	NP_060055	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose	338	Cytoplasmic (Potential).					integral to membrane|plasma membrane	D-glucose transmembrane transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		CAGCACCTTGCGGCCTGCGAG	0.692													7	27					0	0	0	0	T	136339125	T	T	136339125	3	4	289	1	0	0	0	0	1	0	0	0	14613	768	27	1	526	1	SLC2A6	9	136339125	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	34540509	136339125	4874306	114	53683											
FCN1	2219	broad.mit.edu	37	chr9	137806602	137806602	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtctgtcccctggttacCtttgggccccactggtcctg	2	13	11	15	0	1	0	0	0	1	0	3	0	3	0	6	3	1	2	6	3	1	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr9:137806602C>A	uc004cfi.2	-	3	363	c.271G>T	c.(271-273)GGA>TGA	p.G91*		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	91	Collagen-like.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CCCTGGTTACCTTTGGGCCCC	0.463													6	18					2.7689e-08	3.21719e-08	1	0	A	137806602	A	A	137806602	4	1	289	1	0	0	0	0	0	1	0	0	5823	695	24	4	737	4	FCN1	9	137806602	Nonsense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	1467477	137806602	3406829	115	53684											
C10orf18	54906	broad.mit.edu	37	chr10	5791845	5791845	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtatctgcctttcccaggacGgtcagcctcctatgaagaca	9	10	9	13	1	2	2	1	1	1	1	4	3	4	3	4	2	2	1	4	2	3	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr10:5791845G>T	uc001iij.2	+	15	7086	c.6461G>T	c.(6460-6462)CGG>CTG	p.R2154L	C10orf18_uc001iik.2_Missense_Mutation_p.R998L	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2154										ovary(1)|central_nervous_system(1)	2						TTCCCAGGACGGTCAGCCTCC	0.423													9	29					2.74318e-10	3.33003e-10	1	0	T	5791845	T	T	5791845	3	4	289	1	0	0	0	0	1	0	0	0	1602	1116	39	3	6507	3	C10orf18	10	5791845	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08		5791845	129742902	116	53685											
ZNF248	57209	broad.mit.edu	37	chr10	38121317	38121317	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttatattcacggagaatCtttcttgtgtaagctccctg	9	16	7	9	1	3	1	1	0	2	1	4	2	4	1	1	1	1	2	1	1	4	7			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr10:38121317C>A	uc001izd.1	-	6	1465	c.966G>T	c.(964-966)AAG>AAT	p.K322N	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Missense_Mutation_p.K322N	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CACGGAGAATCTTTCTTGTGT	0.368													27	59					4.22769e-11	5.29004e-11	1	0	A	38121317	A	A	38121317	3	1	289	1	0	0	0	0	1	0	0	0	17860	912	32	2	777	2	ZNF248	10	38121317	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	32329472	38121317	97413430	117	53686											
LGI1	9211	broad.mit.edu	37	chr10	95518019	95518019	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggggaagaaaccagcgaagCcaaaatgccctgccgtgtgt	13	5	13	10	2	0	1	0	0	0	1	0	3	0	2	4	2	5	0	4	2	5	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr10:95518019C>A	uc001kjc.3	+	1	454	c.118C>A	c.(118-120)CCA>ACA	p.P40T	LGI1_uc010qnv.1_Missense_Mutation_p.P40T|LGI1_uc001kjd.3_Missense_Mutation_p.P40T|LGI1_uc009xui.2_RNA|LGI1_uc001kje.2_RNA	NM_005097	NP_005088	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1 precursor	40	LRRNT.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4		Colorectal(252;0.124)				ACCAGCGAAGCCAAAATGCCC	0.448													20	57					1.96292e-10	2.39477e-10	1	0	A	95518019	A	A	95518019	3	1	289	1	0	0	0	0	1	0	0	0	8792	739	26	4	120	4	LGI1	10	95518019	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	57396702	95518019	40016728	118	53687											
SLIT1	6585	broad.mit.edu	37	chr10	98764496	98764496	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcctgggtcgtagctgacacGcacatggccctggtacagct	7	8	13	13	2	0	1	0	1	0	0	1	1	0	1	2	3	3	5	2	3	2	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr10:98764496G>T	uc001kmw.2	-	33	3916	c.3664C>A	c.(3664-3666)CGT>AGT	p.R1222S		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1222	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TAGCTGACACGCACATGGCCC	0.612													15	31					6.72482e-11	8.24551e-11	1	0	T	98764496	T	T	98764496	3	4	289	1	0	0	0	0	1	0	0	0	14803	1087	38	3	960	3	SLIT1	10	98764496	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	3246477	98764496	36770251	119	53688											
PDCD11	22984	broad.mit.edu	37	chr10	105184972	105184972	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctgtggaggggccggctGccaagaggaccatgaggccg	7	5	19	10	2	0	2	0	1	0	1	0	4	0	4	4	7	1	2	4	7	1	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr10:105184972G>T	uc001kwy.1	+	20	3082	c.2995G>T	c.(2995-2997)GCC>TCC	p.A999S		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	999					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GGGGCCGGCTGCCAAGAGGAC	0.547													11	22					4.3838e-07	4.95207e-07	1	0	T	105184972	T	T	105184972	3	4	289	1	0	0	0	0	1	0	0	0	11671	1319	46	4	3069	4	PDCD11	10	105184972	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	6420476	105184972	30349775	120	53689											
PHRF1	57661	broad.mit.edu	37	chr11	592631	592631	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaggtgtgcggcaggagcGaccgtgaggacaggcttttg	7	8	19	7	3	0	2	0	2	0	0	0	5	0	4	1	5	2	2	1	5	0	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr11:592631G>T	uc001lqe.2	+	6	708	c.577G>T	c.(577-579)GAC>TAC	p.D193Y	PHRF1_uc010qwc.1_Missense_Mutation_p.D193Y|PHRF1_uc010qwd.1_Missense_Mutation_p.D192Y|PHRF1_uc010qwe.1_Missense_Mutation_p.D189Y|PHRF1_uc009ybz.1_5'UTR	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	193	PHD-type.						RNA polymerase binding|zinc ion binding				0						CGGCAGGAGCGACCGTGAGGA	0.647													64	73					1.25089e-41	1.83865e-41	1	0	T	592631	T	T	592631	3	4	289	1	0	0	0	0	1	0	0	0	11916	1058	37	3	595	3	PHRF1	11	592631	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08		592631	134413885	121	53690											
OR52A5	390054	broad.mit.edu	37	chr11	5153421	5153421	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taagaatggcagccctgagtGtcaccccaagtccaatatga	13	8	9	11	0	1	3	1	2	0	1	2	3	2	3	4	1	1	1	4	1	5	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr11:5153421G>T	uc010qyx.1	-	1	452	c.452C>A	c.(451-453)ACA>AAA	p.T151K		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AGCCCTGAGTGTCACCCCAAG	0.478													19	16					5.03518e-11	6.26829e-11	1	0	T	5153421	T	T	5153421	3	4	289	1	0	0	0	0	1	0	0	0	11164	1377	48	4	501	4	OR52A5	11	5153421	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	4560790	5153421	129853095	122	53691											
KCNC1	3746	broad.mit.edu	37	chr11	17757783	17757783	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cgcacgggcaagctgcactgCccagccgacgtgtgcgggcc	6	4	15	16	5	0	0	0	0	0	0	0	1	0	0	3	2	5	4	3	2	1	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr11:17757783C>G	uc001mnk.3	+	1	289	c.234C>G	c.(232-234)TGC>TGG	p.C78W	KCNC1_uc009yhc.1_Missense_Mutation_p.C78W	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	78	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						AGCTGCACTGCCCAGCCGACG	0.652													16	28					0	0	0	0	G	17757783	G	G	17757783	3	3	289	1	0	0	0	0	1	0	0	0	8053	747	26	4	236	4	KCNC1	11	17757783	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	12604362	17757783	117248733	123	53692											
EHF	26298	broad.mit.edu	37	chr11	34670626	34670627	+	Frame_Shift_Ins	INS	-	TG	TG																															attgtcaagactgaacaaacINStggtgagtagtagtggacaa																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr11:34670626_34670627insTG	uc001mvr.1	+	4	515_516	c.404_405insTG	c.(403-405)ACTfs	p.T135fs	EHF_uc009yke.1_Frame_Shift_Ins_p.T135fs|EHF_uc009ykf.1_Frame_Shift_Ins_p.T138fs	NM_012153	NP_036285	Q9NZC4	EHF_HUMAN	ets homologous factor	135					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			ACTGAACAAACTGGTGAGTAGT	0.525													---	---	---								TG	34670627	TG	TG	34670626	7	5	289	1	0	1	1	0	0	0	0	0	5003	565	20	0	414	0	EHF	11	34670626	Frame_Shift_Ins	INS	-	TCGA-DQ-7589-01A-11D-2229-08	16912843	34670626	100335890	124	53693											
OR4A15	81328	broad.mit.edu	37	chr11	55136039	55136039	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgtcactgggctttctaTgatagctaatggaggagcga	10	12	12	7	1	2	1	1	1	1	0	2	4	2	3	0	3	2	2	0	3	4	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr11:55136039T>A	uc010rif.1	+	1	680	c.680T>A	c.(679-681)ATG>AAG	p.M227K		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	227	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGGCTTTCTATGATAGCTAAT	0.438													15	46					0	0	0	0	A	55136039	A	A	55136039	3	1	289	1	0	0	0	0	1	0	0	0	11094	1464	51	5	682	5	OR4A15	11	55136039	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	20465413	55136039	79870477	125	53694											
OR5D16	390144	broad.mit.edu	37	chr11	55606467	55606467	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctattcctccatcattgcTcccatgatgctggtgaacct	7	14	7	13	0	1	2	1	2	0	0	4	2	4	2	4	1	4	3	4	1	2	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr11:55606467T>A	uc010rio.1	+	1	240	c.240T>A	c.(238-240)GCT>GCA	p.A80A		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				CCATCATTGCTCCCATGATGC	0.393													85	158					0	0	0	0	A	55606467	A	A	55606467	2	1	289	1	0	0	0	0	0	0	0	1	11210	1538	54	5		5	OR5D16	11	55606467	Silent	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	470428	55606467	79400049	126	53695											
OR8H1	219469	broad.mit.edu	37	chr11	56058246	56058246	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agacaaaaaagaacatctggGcaaagcagcccatgaaggaa	20	3	10	8	0	1	3	0	1	1	2	1	4	1	4	1	2	3	2	1	2	7	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr11:56058246G>T	uc010rje.1	-	1	293	c.293C>A	c.(292-294)GCC>GAC	p.A98D		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GAACATCTGGGCAAAGCAGCC	0.423													50	114					2.17126e-26	3.06235e-26	1	0	T	56058246	T	T	56058246	3	4	289	1	0	0	0	0	1	0	0	0	11291	1203	42	4	644	4	OR8H1	11	56058246	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	451779	56058246	78948270	127	53696											
NAALAD2	10003	broad.mit.edu	37	chr11	89885504	89885504	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggagccataggaatcatCttgtactcagatccagctga	12	9	10	10	0	3	2	2	1	1	1	4	4	4	4	2	2	3	3	2	2	3	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr11:89885504C>T	uc001pdf.3	+	6	757	c.648C>T	c.(646-648)ATC>ATT	p.I216I	NAALAD2_uc009yvx.2_Silent_p.I216I|NAALAD2_uc009yvy.2_Silent_p.I216I|NAALAD2_uc001pdd.2_Silent_p.I216I|NAALAD2_uc001pde.2_Silent_p.I216I	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	216	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TAGGAATCATCTTGTACTCAG	0.438													14	37					0	0	0	0	T	89885504	T	T	89885504	2	4	289	1	0	0	0	0	0	0	0	1	10181	903	32	2		2	NAALAD2	11	89885504	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	33827258	89885504	45121012	128	53697											
MMP1	4312	broad.mit.edu	37	chr11	102663440	102663440	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgaaattgagctcaacttccGggtagaagggatttgtgcgc	10	11	13	7	2	1	3	1	2	0	1	2	4	2	4	1	2	3	2	1	2	4	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr11:102663440G>T	uc001phi.2	-	7	1072	c.929C>A	c.(928-930)CCG>CAG	p.P310Q	uc001phh.1_Intron|MMP1_uc010ruv.1_Missense_Mutation_p.P244Q	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	310	Hemopexin-like 1.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		CTCAACTTCCGGGTAGAAGGG	0.428													21	52					1.10513e-12	1.40444e-12	1	0	T	102663440	T	T	102663440	3	4	289	1	0	0	0	0	1	0	0	0	9701	1116	39	3	496	3	MMP1	11	102663440	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	12777936	102663440	32343076	129	53698											
DYNC2H1	79659	broad.mit.edu	37	chr11	102991188	102991188	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattttaggtcttggctattAgaacaattcatgagaagttt	12	16	8	5	0	2	2	1	1	1	2	2	3	2	2	0	2	1	2	0	2	6	7			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr11:102991188A>T	uc001pho.2	+	7	1156	c.1012A>T	c.(1012-1014)AGA>TGA	p.R338*	DYNC2H1_uc001phn.1_Nonsense_Mutation_p.R338*|DYNC2H1_uc009yxe.1_Nonsense_Mutation_p.R338*	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	338	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CTTGGCTATTAGAACAATTCA	0.328													9	37					0	0	0	0	T	102991188	T	T	102991188	4	4	289	1	0	0	0	0	0	1	0	0	4868	412	15	5	1038	5	DYNC2H1	11	102991188	Nonsense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	327748	102991188	32015328	130	53699											
KCNA6	3742	broad.mit.edu	37	chr12	4919519	4919519	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tactactaccagtctgggggCcgcctgcggaggccggtcaa	7	7	14	13	3	2	0	1	0	1	0	2	1	2	1	4	5	4	0	4	5	4	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:4919519C>A	uc001qng.2	+	1	1178	c.312C>A	c.(310-312)GGC>GGA	p.G104G		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	104						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						AGTCTGGGGGCCGCCTGCGGA	0.662										HNSCC(72;0.22)			27	97					7.11191e-15	9.27971e-15	1	0	A	4919519	A	A	4919519	2	1	289	1	0	0	0	0	0	0	0	1	8046	726	26	4		4	KCNA6	12	4919519	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08		4919519	128932376	131	53700											
ATF7IP	55729	broad.mit.edu	37	chr12	14591086	14591086	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatacagtggttgctggaagAaaaattgtgtgcgctgcagt	11	12	13	5	1	0	1	0	0	0	1	0	2	0	2	0	2	4	4	0	2	5	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:14591086A>G	uc001rbw.2	+	5	1972	c.1814A>G	c.(1813-1815)GAA>GGA	p.E605G	ATF7IP_uc010shs.1_Missense_Mutation_p.E604G|ATF7IP_uc001rbu.2_Missense_Mutation_p.E605G|ATF7IP_uc001rbv.1_Missense_Mutation_p.E604G|ATF7IP_uc001rbx.2_Missense_Mutation_p.E604G|ATF7IP_uc010sht.1_Missense_Mutation_p.E605G|ATF7IP_uc001rby.3_Missense_Mutation_p.E605G|ATF7IP_uc001rca.2_Missense_Mutation_p.E605G	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	605	Interaction with SETDB1.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						TTGCTGGAAGAAAAATTGTGT	0.338													12	18					0	0	0	0	G	14591086	G	G	14591086	3	3	289	1	0	0	0	0	1	0	0	0	1089	246	9	5	1828	5	ATF7IP	12	14591086	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	9671567	14591086	119260809	132	53701											
GYS2	2998	broad.mit.edu	37	chr12	21733364	21733364	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccacctgagtcttcatattaTgctcaaaatatggacctatc	12	13	5	11	0	3	1	2	1	1	0	4	2	3	2	3	1	1	1	3	1	6	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:21733364T>A	uc001rfb.2	-	2	470	c.215A>T	c.(214-216)CAT>CTT	p.H72L		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	72					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						CTTCATATTATGCTCAAAATA	0.423													42	82					0	0	0	0	A	21733364	A	A	21733364	3	1	289	1	0	0	0	0	1	0	0	0	6952	1464	51	5	1956	5	GYS2	12	21733364	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	7142278	21733364	112118531	133	53702											
CASC1	55259	broad.mit.edu	37	chr12	25297596	25297596	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaatttgtgtttcagagaaTctaacacttctgtgcctgtt	9	16	7	9	0	3	1	1	0	2	1	3	2	3	1	2	0	2	2	2	0	3	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:25297596T>C	uc001rgl.2	-	8	769	c.687A>G	c.(685-687)AGA>AGG	p.R229R	CASC1_uc001rgk.2_Silent_p.R235R|CASC1_uc001rgm.3_Silent_p.R293R|CASC1_uc001rgj.2_Silent_p.R189R|CASC1_uc010sje.1_Silent_p.R170R|CASC1_uc010sjf.1_Silent_p.R117R|CASC1_uc010sjg.1_Silent_p.R229R	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	229										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TTTCAGAGAATCTAACACTTC	0.358													10	23					0	0	0	0	C	25297596	C	C	25297596	2	2	289	1	0	0	0	0	0	0	0	1	2672	1432	50	5		5	CASC1	12	25297596	Silent	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	3564232	25297596	108554299	134	53703											
CNTN1	1272	broad.mit.edu	37	chr12	41410718	41410718	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcattaattcagcacaagacGgtaggtgaaagaaagacctt	16	9	9	7	1	2	4	2	1	0	3	2	4	2	4	1	2	1	2	1	2	5	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:41410718G>A	uc001rmm.1	+	19	2532	c.2419G>A	c.(2419-2421)GCT>ACT	p.A807T	CNTN1_uc001rmn.1_Missense_Mutation_p.A796T	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	807					axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AGCACAAGACGGTAGGTGAAA	0.428													12	18					0	0	0	0	A	41410718	A	A	41410718	3	1	289	1	0	0	0	0	1	0	0	0	3655	1130	39	1	2489	1	CNTN1	12	41410718	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	16113122	41410718	92441177	135	53704											
ARID2	196528	broad.mit.edu	37	chr12	46211563	46211563	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caaatgaagtggactttgctAttaacgtatgcactctccta	12	13	7	9	1	1	1	0	1	1	0	2	2	1	2	1	1	3	3	1	1	6	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:46211563A>G	uc001ros.1	+	5	529	c.529A>G	c.(529-531)ATT>GTT	p.I177V	ARID2_uc001ror.2_Missense_Mutation_p.I177V	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	177					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GGACTTTGCTATTAACGTATG	0.383													16	33					0	0	0	0	G	46211563	G	G	46211563	3	3	289	1	0	0	0	0	1	0	0	0	915	449	16	5	547	5	ARID2	12	46211563	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	4800845	46211563	87640332	136	53705											
PDE1B	5153	broad.mit.edu	37	chr12	54960852	54960852	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcttctctgctggaagccGtctacatagatgagacacgg	10	9	11	11	2	2	2	0	1	2	2	3	4	2	3	1	2	4	2	1	2	3	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:54960852G>T	uc001sgd.1	+	3	374	c.208G>T	c.(208-210)GTC>TTC	p.V70F	PDE1B_uc010soz.1_5'UTR|PDE1B_uc010spa.1_Missense_Mutation_p.V29F|PDE1B_uc001sgf.2_5'UTR|PDE1B_uc001sge.2_Missense_Mutation_p.V50F|PDE1B_uc009znq.2_5'UTR	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	70					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCTGGAAGCCGTCTACATAGA	0.274													6	11					8.12818e-05	8.89362e-05	1	0	T	54960852	T	T	54960852	3	4	289	1	0	0	0	0	1	0	0	0	11688	1145	40	3	271	3	PDE1B	12	54960852	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	8749289	54960852	78891043	137	53706											
LRP1	4035	broad.mit.edu	37	chr12	57588842	57588842	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagtggctgtgtgacggcAgcgatgactgtggggatggc	7	8	19	7	2	0	2	0	2	0	0	0	4	0	3	0	5	2	3	0	5	0	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:57588842A>G	uc001snd.2	+	51	8732	c.8266A>G	c.(8266-8268)AGC>GGC	p.S2756G		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2756	Extracellular (Potential).|LDL-receptor class A 16.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GTGTGACGGCAGCGATGACTG	0.612													52	168					0	0	0	0	G	57588842	G	G	57588842	3	3	289	1	0	0	0	0	1	0	0	0	9001	188	7	5	8468	5	LRP1	12	57588842	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	2627990	57588842	76263053	138	53707											
KCNC2	3747	broad.mit.edu	37	chr12	75444618	75444618	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aatatcaaaactcctagagcCaggaaaattatcagcagcaa	19	7	6	9	0	2	1	2	0	0	1	3	2	3	2	2	1	4	2	2	1	9	3	rs139012036	byFrequency	TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:75444618C>T	uc001sxg.1	-	3	1711	c.1167G>A	c.(1165-1167)CTG>CTA	p.L389L	KCNC2_uc009zry.2_Silent_p.L389L|KCNC2_uc001sxe.2_Silent_p.L389L|KCNC2_uc001sxf.2_Silent_p.L389L|KCNC2_uc010stw.1_Silent_p.L389L	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	389	Helical; Name=Segment S5; (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						CTCCTAGAGCCAGGAAAATTA	0.438													11	37					0	0	0	0	T	75444618	T	T	75444618	2	4	289	1	0	0	0	0	0	0	0	1	8054	581	21	4		4	KCNC2	12	75444618	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	17855776	75444618	58407277	139	53708											
ACSS3	79611	broad.mit.edu	37	chr12	81503351	81503351	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttcaggtttgtggaaggAatgcttaacatttgttacaa	11	17	9	4	0	1	0	1	0	0	0	1	2	1	2	0	3	3	3	0	3	5	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:81503351A>G	uc001szl.1	+	2	415	c.324A>G	c.(322-324)GGA>GGG	p.G108G	ACSS3_uc001szm.1_Silent_p.G107G	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	108						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TTGTGGAAGGAATGCTTAACA	0.308													12	35					0	0	0	0	G	81503351	G	G	81503351	2	3	289	1	0	0	0	0	0	0	0	1	190	233	9	5		5	ACSS3	12	81503351	Silent	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	6058733	81503351	52348544	140	53709											
STAB2	55576	broad.mit.edu	37	chr12	104089346	104089346	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgctggtcccacaaagaCgtctaactggctccttacca	10	9	9	13	1	1	1	0	0	1	1	3	1	3	1	3	3	3	2	3	3	3	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:104089346C>G	uc001tjw.2	+	32	3580	c.3394C>G	c.(3394-3396)CGT>GGT	p.R1132G		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1132	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCCACAAAGACGTCTAACTGG	0.478													22	44					0	0	0	0	G	104089346	G	G	104089346	3	3	289	1	0	0	0	0	1	0	0	0	15304	536	19	3	3520	3	STAB2	12	104089346	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	22585995	104089346	29762549	141	53710											
SLC24A6	80024	broad.mit.edu	37	chr12	113754408	113754409	+	Missense_Mutation	DNP	CC	AA	AA																															caggggattgagggcccggaCcaggatctgagccgtggtct																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:113754408_113754409CC>AA	uc001tvc.2	-	10	1125_1126	c.915_916GG>TT	c.(913-918)CTGGTC>CTTTTC	p.V306F	SLC24A6_uc001tuz.2_Missense_Mutation_p.V11F|SLC24A6_uc001tva.2_RNA|SLC24A6_uc001tvb.2_Missense_Mutation_p.V44F	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	306	Cytoplasmic (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						AGGGCCCGGACCAGGATCTGAG	0.589													63	259					0	0	0	0	AA	113754409	AA	AA	113754408	3	1	289	1	0	0	0	0	1	0	0	0	14534	507	18	4	866	4	SLC24A6	12	113754408	Missense_Mutation	DNP	CC	TCGA-DQ-7589-01A-11D-2229-08	9665062	113754408	20097487	142	53711											
TMEM132B	114795	broad.mit.edu	37	chr12	125900196	125900196	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcggccaccctcacctgcaTgggccatcgcccggacacgc	6	5	11	19	4	1	0	1	0	0	0	3	1	1	1	5	3	1	1	5	3	0	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:125900196T>A	uc001uhe.1	+	3	1072	c.1064T>A	c.(1063-1065)ATG>AAG	p.M355K		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	355	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CTCACCTGCATGGGCCATCGC	0.587													18	45					0	0	0	0	A	125900196	A	A	125900196	3	1	289	1	0	0	0	0	1	0	0	0	16112	1464	51	5	1074	5	TMEM132B	12	125900196	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	12145788	125900196	7951699	143	53712											
PIWIL1	9271	broad.mit.edu	37	chr12	130851759	130851759	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaggaagacttcagaatccActtcctggaacagttattga	13	10	10	8	0	1	3	1	1	0	2	3	6	3	6	2	3	1	1	2	3	4	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr12:130851759A>G	uc001uik.2	+	19	2367	c.2277A>G	c.(2275-2277)CCA>CCG	p.P759P	PIWIL1_uc001uij.1_Silent_p.P759P	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	759	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		TTCAGAATCCACTTCCTGGAA	0.408													29	94					0	0	0	0	G	130851759	G	G	130851759	2	3	289	1	0	0	0	0	0	0	0	1	12012	146	6	5		5	PIWIL1	12	130851759	Silent	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	4951563	130851759	3000136	144	53713											
ATP8A2	51761	broad.mit.edu	37	chr13	26125580	26125580	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcatggccttggtgagctcGgcgggggccctgtactggaa	5	9	17	10	2	1	1	1	1	0	0	2	2	1	2	2	6	2	2	2	6	2	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr13:26125580G>T	uc001uqk.2	+	11	1138	c.996G>T	c.(994-996)TCG>TCT	p.S332S	ATP8A2_uc010tdi.1_Silent_p.S292S|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Silent_p.S292S	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	292	Helical; (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TGGTGAGCTCGGCGGGGGCCC	0.512													14	31					0.000219431	0.000233805	1	0	T	26125580	T	T	26125580	2	4	289	1	0	0	0	0	0	0	0	1	1195	1103	39	3		3	ATP8A2	13	26125580	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08		26125580	89044298	145	53714											
MAB21L1	4081	broad.mit.edu	37	chr13	36050122	36050122	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctcgttgagagagctgatgaAccgcggctcctgcacttcca	8	9	11	13	3	0	4	0	3	0	1	3	5	2	4	3	1	3	4	3	1	1	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr13:36050122A>C	uc001uvc.2	-	1	711	c.154T>G	c.(154-156)TTC>GTC	p.F52V	NBEA_uc001uvb.2_Intron|NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_5'Flank|NBEA_uc010teg.1_5'Flank	NM_005584	NP_005575	Q13394	MB211_HUMAN	mab-21-like protein 1	52					anatomical structure morphogenesis	nucleus				ovary(2)	2		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		GAGCTGATGAACCGCGGCTCC	0.517													17	71					0	0	0	0	C	36050122	C	C	36050122	3	2	289	1	0	0	0	0	1	0	0	0	9192	43	2	5	929	5	MAB21L1	13	36050122	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	9924542	36050122	79119756	146	53715											
C13orf18	80183	broad.mit.edu	37	chr13	46942902	46942902	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caggcagcacaaatacctctGgtgagaaggaattcgaagaa	16	6	11	8	1	1	2	0	1	1	2	2	5	1	3	1	3	2	2	1	3	6	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr13:46942902G>C	uc010acl.2	-	4	1189	c.584C>G	c.(583-585)CCA>CGA	p.P195R	C13orf18_uc001vbf.3_Missense_Mutation_p.P128R|C13orf18_uc001vbg.3_5'UTR|C13orf18_uc010tfz.1_Missense_Mutation_p.P38R|C13orf18_uc010acm.2_Missense_Mutation_p.P60R|C13orf18_uc010acn.2_5'UTR|C13orf18_uc001vbe.3_Missense_Mutation_p.P195R|C13orf18_uc001vbh.3_Missense_Mutation_p.P195R|C13orf18_uc001vbi.3_Missense_Mutation_p.P38R|C13orf18_uc010aco.1_Missense_Mutation_p.P195R|C13orf18_uc010tga.1_Missense_Mutation_p.P128R	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	195											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		AAATACCTCTGGTGAGAAGGA	0.358													20	95					0	0	0	0	C	46942902	C	C	46942902	3	2	289	1	0	0	0	0	1	0	0	0	1726	1348	47	4	1452	4	C13orf18	13	46942902	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	10892780	46942902	68226976	147	53716											
OLFM4	10562	broad.mit.edu	37	chr13	53603078	53603078	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccagccccggcttcagctCtttcccaggtgttgactcca	5	11	8	17	1	2	1	1	1	1	0	5	1	5	1	5	2	2	3	5	2	0	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr13:53603078C>G	uc001vhl.2	+	1	107	c.107C>G	c.(106-108)TCT>TGT	p.S36C	OLFM4_uc001vhk.1_Missense_Mutation_p.S36C	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	36	Ser-rich.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GGCTTCAGCTCTTTCCCAGGT	0.428													42	98					0	0	0	0	G	53603078	G	G	53603078	3	3	289	1	0	0	0	0	1	0	0	0	10909	913	32	2	109	2	OLFM4	13	53603078	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	6660176	53603078	61566800	148	53717											
FARP1	10160	broad.mit.edu	37	chr13	99064263	99064263	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttcatactaattttctcaagGaaattgagcaacgacttgcc	13	13	6	9	1	2	1	2	1	1	0	3	3	2	2	1	1	4	1	1	1	5	7			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr13:99064263G>A	uc001vnj.2	+	16	2137	c.1801G>A	c.(1801-1803)GAA>AAA	p.E601K	FARP1_uc001vnh.2_Missense_Mutation_p.E601K	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	601	DH.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TTTTCTCAAGGAAATTGAGCA	0.448													62	100					0	0	0	0	A	99064263	A	A	99064263	3	1	289	1	0	0	0	0	1	0	0	0	5708	1175	41	2	2082	2	FARP1	13	99064263	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	45461185	99064263	16105615	149	53718											
DOCK9	23348	broad.mit.edu	37	chr13	99483677	99483677	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	atcaggaagtagagcagctgGgaggcctccgtcctgatgga	10	7	15	9	1	1	2	1	1	0	1	3	5	3	5	3	4	2	3	3	4	2	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr13:99483677G>C	uc001vnt.2	-	41	4549	c.4494C>G	c.(4492-4494)TCC>TCG	p.S1498S	DOCK9_uc001vnw.2_Silent_p.S1497S|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.S1498S|DOCK9_uc001vnq.2_Silent_p.S70S|DOCK9_uc001vnr.2_Silent_p.S141S|DOCK9_uc010tin.1_Silent_p.S141S|DOCK9_uc001vns.2_Silent_p.S70S|DOCK9_uc010tio.1_Silent_p.S190S|DOCK9_uc010tip.1_Silent_p.S208S|DOCK9_uc001vnu.1_Silent_p.S70S|DOCK9_uc010tiq.1_Silent_p.S476S	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1498					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AGAGCAGCTGGGAGGCCTCCG	0.488													5	7					0	0	0	0	C	99483677	C	C	99483677	2	2	289	1	0	0	0	0	0	0	0	1	4716	1219	43	4		4	DOCK9	13	99483677	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	419414	99483677	15686201	150	53719											
MDGA2	161357	broad.mit.edu	37	chr14	47426704	47426704	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctgagagtcaaattgaccCgtccgtaataatttattgcc	11	13	7	10	2	1	2	1	2	0	1	3	3	3	2	4	0	1	1	4	0	4	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr14:47426704C>T	uc001wwj.3	-	9	1951	c.1755G>A	c.(1753-1755)ACG>ACA	p.T585T	MDGA2_uc001wwi.3_Silent_p.T356T|MDGA2_uc010ani.2_Silent_p.T145T	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	585	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CAAATTGACCCGTCCGTAATA	0.443													33	62					0	0	0	0	T	47426704	T	T	47426704	2	4	289	1	0	0	0	0	0	0	0	1	9460	639	23	1		1	MDGA2	14	47426704	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08		47426704	59922836	151	53720											
ADAM21	8747	broad.mit.edu	37	chr14	70924239	70924239	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcagtggatgggaccctcgTgtacatcagagtcactcttc	8	10	12	11	1	3	1	2	0	1	1	5	3	3	3	1	3	1	2	1	3	1	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr14:70924239T>G	uc001xmd.2	+	1	23	c.23T>G	c.(22-24)GTG>GGG	p.V8G		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	8					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GGGACCCTCGTGTACATCAGA	0.542													39	171					0	0	0	0	G	70924239	G	G	70924239	3	3	289	1	0	0	0	0	1	0	0	0	243	1696	59	5	25	5	ADAM21	14	70924239	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	23497535	70924239	36425301	152	53721											
BATF	10538	broad.mit.edu	37	chr14	75991484	75991484	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaaatcgtattgccgccCagaagagccgacagaggcag	15	4	12	10	3	0	4	0	0	0	4	1	5	0	4	3	1	2	2	3	1	4	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr14:75991484C>A	uc001xrr.2	+	2	363	c.121C>A	c.(121-123)CAG>AAG	p.Q41K		NM_006399	NP_006390	Q16520	BATF_HUMAN	basic leucine zipper transcription factor,	41	Basic motif.					nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.028)		TATTGCCGCCCAGAAGAGCCG	0.537													9	18					2.17888e-05	2.40564e-05	1	0	A	75991484	A	A	75991484	3	1	289	1	0	0	0	0	1	0	0	0	1327	595	21	4	127	4	BATF	14	75991484	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	5067245	75991484	31358056	153	53722											
ANGEL1	23357	broad.mit.edu	37	chr14	77275617	77275617	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tggggatagctgcccacatgGagccctccaccccctccacc	7	6	9	19	0	0	0	0	0	0	0	2	2	2	2	7	3	3	1	7	3	1	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr14:77275617G>A	uc001xsv.2	-	2	547	c.434C>T	c.(433-435)TCC>TTC	p.S145F	ANGEL1_uc010tvf.1_Missense_Mutation_p.S145F	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	145										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TGCCCACATGGAGCCCTCCAC	0.632													7	11					0	0	0	0	A	77275617	A	A	77275617	3	1	289	1	0	0	0	0	1	0	0	0	608	1174	41	2	1614	2	ANGEL1	14	77275617	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	1284133	77275617	30073923	154	53723											
EML5	161436	broad.mit.edu	37	chr14	89171267	89171268	+	Frame_Shift_Ins	INS	-	T	T																															tcttcttttagaagtagcacINSttttttgtttctctttgcac																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr14:89171267_89171268insT	uc001xxg.2	-	14	2173_2174	c.1987_1988insA	c.(1987-1989)AGTfs	p.S663fs	EML5_uc001xxh.1_5'UTR	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	663						cytoplasm|microtubule				ovary(3)	3						AGAAGTAGCACTTTTTTGTTTC	0.302													---	---	---								T	89171268	T	T	89171267	7	5	289	1	0	1	1	0	0	0	0	0	5124	565	20	0	4069	0	EML5	14	89171267	Frame_Shift_Ins	INS	-	TCGA-DQ-7589-01A-11D-2229-08	11895650	89171267	18178273	155	53724											
JAG2	3714	broad.mit.edu	37	chr14	105618508	105618508	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctaccactacctttgtcacaGagcaggccgccccagttggt	8	9	9	15	1	1	1	1	0	0	1	1	1	1	1	5	2	3	2	5	2	2	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr14:105618508G>C	uc001yqg.2	-	6	1313	c.909C>G	c.(907-909)CTC>CTG	p.L303L	JAG2_uc001yqf.2_5'Flank|JAG2_uc001yqh.2_Silent_p.L303L	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	303	Extracellular (Potential).|EGF-like 2; atypical.				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CTTTGTCACAGAGCAGGCCGC	0.637													56	128					0	0	0	0	C	105618508	C	C	105618508	2	2	289	1	0	0	0	0	0	0	0	1	7974	929	33	2		2	JAG2	14	105618508	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	16447241	105618508	1731032	156	53725											
OTUD7A	161725	broad.mit.edu	37	chr15	31794041	31794041	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgaatgggatgggtgcgaaCgctgtggacacaaaccaggg	11	5	16	9	3	0	0	0	0	0	0	0	4	0	2	2	4	3	1	2	4	3	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr15:31794041C>G	uc001zfq.2	-	8	1095	c.1002G>C	c.(1000-1002)GCG>GCC	p.A334A	OTUD7A_uc001zfr.2_Silent_p.A341A	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	334	OTU.|Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		TGGGTGCGAACGCTGTGGACA	0.632													27	68					0	0	0	0	G	31794041	G	G	31794041	2	3	289	1	0	0	0	0	0	0	0	1	11372	550	19	3		3	OTUD7A	15	31794041	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08		31794041	70737351	157	53726											
USP3	9960	broad.mit.edu	37	chr15	63855163	63855163	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agccagactgcatttagcccAgagtccttattttatgttgt	9	15	8	9	0	0	2	0	0	0	2	1	2	1	2	3	0	3	2	3	0	3	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr15:63855163A>G	uc002amf.2	+	8	846	c.717A>G	c.(715-717)CCA>CCG	p.P239P	USP3_uc010uii.1_RNA|USP3_uc002amg.2_Silent_p.P154P|USP3_uc002amh.2_Silent_p.P217P|USP3_uc010uij.1_Silent_p.P195P|USP3_uc010uik.1_5'UTR|USP3_uc010bgs.2_Silent_p.P222P|USP3_uc002ami.2_Silent_p.P70P	NM_006537	NP_006528	Q9Y6I4	UBP3_HUMAN	ubiquitin thiolesterase 3	239					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(80;0.0187)		CATTTAGCCCAGAGTCCTTAT	0.363													47	96					0	0	0	0	G	63855163	G	G	63855163	2	3	289	1	0	0	0	0	0	0	0	1	17128	175	7	5		5	USP3	15	63855163	Silent	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	32061122	63855163	38676229	158	53727											
IGDCC3	9543	broad.mit.edu	37	chr15	65625630	65625630	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccctgtgccgttctcctcAcccgggtgccaggtctgttg	2	11	13	15	2	3	0	1	0	2	0	4	0	3	0	5	3	2	2	5	3	0	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr15:65625630A>T	uc002aos.2	-	6	1199	c.947T>A	c.(946-948)GTG>GAG	p.V316E		NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	316	Extracellular (Potential).|Ig-like C2-type 3.									ovary(3)	3						CGTTCTCCTCACCCGGGTGCC	0.632													18	84					0	0	0	0	T	65625630	T	T	65625630	3	4	289	1	0	0	0	0	1	0	0	0	7607	159	6	5	1533	5	IGDCC3	15	65625630	Missense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	1770467	65625630	36905762	159	53728											
HEXA	3073	broad.mit.edu	37	chr15	72638920	72638921	+	Frame_Shift_Ins	INS	-	GATA	GATA																															ccttccagtcagggccatagINSgatatacggttcaggtacca																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr15:72638920_72638921insGATA	uc002aun.3	-	11	1484_1485	c.1277_1278insTATC	c.(1276-1278)TCCfs	p.S426fs	uc002aug.2_RNA|CELF6_uc002auk.3_Intron|HEXA_uc010ukn.1_Frame_Shift_Ins_p.S437fs|HEXA_uc002auo.3_Frame_Shift_Ins_p.S289fs|HEXA_uc010bix.2_Frame_Shift_Ins_p.S426fs|HEXA_uc010biy.2_Frame_Shift_Ins_p.S289fs|HEXA_uc010uko.1_Frame_Shift_Ins_p.S252fs|HEXA_uc010biz.1_RNA	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	426					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			ovary(3)|upper_aerodigestive_tract(1)	4						CAGGGCCATAGGATATACGGTT	0.54													---	---	---								GATA	72638921	GATA	GATA	72638920	7	5	289	1	0	1	1	0	0	0	0	0	7112	987	35	0	327	0	HEXA	15	72638920	Frame_Shift_Ins	INS	-	TCGA-DQ-7589-01A-11D-2229-08	7013290	72638920	29892472	160	53729											
OTOA	146183	broad.mit.edu	37	chr16	21747666	21747666	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgggctgtctttcagtctGttcggaacagcagtgataag	8	13	12	8	1	4	1	1	1	3	0	5	2	4	2	0	2	2	3	0	2	2	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr16:21747666G>T	uc002djh.2	+	21	2387	c.2386G>T	c.(2386-2388)GTT>TTT	p.V796F	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.V717F|OTOA_uc002dji.2_Missense_Mutation_p.V472F|OTOA_uc010vbk.1_Missense_Mutation_p.V444F	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	810					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		CTTTCAGTCTGTTCGGAACAG	0.473													57	60					2.18419e-29	3.11663e-29	1	0	T	21747666	T	T	21747666	3	4	289	1	0	0	0	0	1	0	0	0	11356	1377	48	4	2514	4	OTOA	16	21747666	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08		21747666	68607087	161	53730											
FBRS	64319	broad.mit.edu	37	chr16	30680766	30680766	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccgtggccgctgcccgcCtctacggtctggaacctgct	3	8	14	16	4	2	0	0	0	2	0	2	1	2	1	5	4	4	2	5	4	2	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr16:30680766C>A	uc002dzd.3	+	12	1446	c.1183C>A	c.(1183-1185)CTC>ATC	p.L395I	FBRS_uc002dzc.3_Missense_Mutation_p.L307I	NM_001105079	NP_001098549	Q9HAH7	FBRS_HUMAN	fibrosin	395	Pro-rich.									ovary(1)	1			Colorectal(24;0.103)			CGCTGCCCGCCTCTACGGTCT	0.682													32	148					3.90053e-15	5.14448e-15	1	0	A	30680766	A	A	30680766	3	1	289	1	0	0	0	0	1	0	0	0	5739	681	24	4	1225	4	FBRS	16	30680766	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	8933100	30680766	59673987	162	53731											
TRIM72	493829	broad.mit.edu	37	chr16	31230629	31230629	+	Frame_Shift_Del	DEL	G	-	-																															ggagacagtgcgtcagttccGgggggccgtgggggagcagc																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr16:31230629delG	uc002ebn.1	+	4	735	c.506delG	c.(505-507)CGGfs	p.R169fs	PYDC1_uc002ebo.2_5'Flank	NM_001008274	NP_001008275	Q6ZMU5	TRI72_HUMAN	tripartite motif-containing 72	169	Potential.				exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding				0						CGTCAGTTCCGGGGGGCCGTG	0.657													---	---	---								-	31230629	-	-	31230629	7	5	289	1	0	1	0	1	0	0	0	0	16612	1116	39	0	516	0	TRIM72	16	31230629	Frame_Shift_Del	DEL	G	TCGA-DQ-7589-01A-11D-2229-08	549863	31230629	59124124	163	53732											
NFATC3	4775	broad.mit.edu	37	chr16	68217251	68217251	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaaaaaaagccagtctcaaCgttttacttatacaccaggt	15	10	7	9	1	1	0	1	0	1	0	2	1	1	1	2	2	4	1	2	2	7	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr16:68217251C>T	uc002evo.1	+	8	2290	c.2080C>T	c.(2080-2082)CGT>TGT	p.R694C	NFATC3_uc010vkl.1_Missense_Mutation_p.R215C|NFATC3_uc010vkm.1_Missense_Mutation_p.R215C|NFATC3_uc010vkn.1_Missense_Mutation_p.R215C|NFATC3_uc010vko.1_Missense_Mutation_p.R215C|NFATC3_uc010vkp.1_Missense_Mutation_p.R215C|NFATC3_uc010vkq.1_Missense_Mutation_p.R215C|NFATC3_uc002evl.2_Missense_Mutation_p.R215C|NFATC3_uc002evk.2_Missense_Mutation_p.R694C|NFATC3_uc002evm.1_Missense_Mutation_p.R694C|NFATC3_uc002evn.1_Missense_Mutation_p.R694C|NFATC3_uc010vkr.1_Missense_Mutation_p.R215C|NFATC3_uc010vks.1_Missense_Mutation_p.R215C|NFATC3_uc010vkt.1_Missense_Mutation_p.R215C|NFATC3_uc010vku.1_Missense_Mutation_p.R215C|NFATC3_uc010vkv.1_Missense_Mutation_p.R215C|NFATC3_uc010vkw.1_Missense_Mutation_p.R215C|NFATC3_uc010vkx.1_Missense_Mutation_p.R215C|NFATC3_uc010vky.1_Missense_Mutation_p.R215C|NFATC3_uc010vkz.1_Missense_Mutation_p.R215C|NFATC3_uc010vla.1_Missense_Mutation_p.R215C|NFATC3_uc010vlb.1_Missense_Mutation_p.R215C|NFATC3_uc010vlc.1_Missense_Mutation_p.R215C	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	694					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		CCAGTCTCAACGTTTTACTTA	0.383													23	30					0	0	0	0	T	68217251	T	T	68217251	3	4	289	1	0	0	0	0	1	0	0	0	10418	536	19	1	2110	1	NFATC3	16	68217251	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	36986622	68217251	22137502	164	53733											
ADAMTS18	170692	broad.mit.edu	37	chr16	77397723	77397723	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tcttgttccagaagaattagGctcaccacaaccacgtttat	12	12	6	11	1	2	2	1	0	1	2	3	2	3	2	3	1	1	3	3	1	5	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr16:77397723G>T	uc002ffc.3	-	6	1451	c.1032C>A	c.(1030-1032)AGC>AGA	p.S344R	ADAMTS18_uc010chc.1_5'UTR|ADAMTS18_uc002ffe.1_Missense_Mutation_p.S40R|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	344	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GAAGAATTAGGCTCACCACAA	0.308													36	27					4.16155e-14	5.40115e-14	1	0	T	77397723	T	T	77397723	3	4	289	1	0	0	0	0	1	0	0	0	263	1194	42	4	2705	4	ADAMTS18	16	77397723	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	9180472	77397723	12957030	165	53734											
ZNF18	7566	broad.mit.edu	37	chr17	11894342	11894342	+	Frame_Shift_Del	DEL	C	-	-																															cacgatgtggctcagaagctCcccaggccctgaggatgaat																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr17:11894342delC	uc002gng.1	-	5	1131	c.526delG	c.(526-528)GAGfs	p.E176fs	ZNF18_uc002gnh.1_Frame_Shift_Del_p.E176fs|ZNF18_uc002gni.1_Frame_Shift_Del_p.E176fs	NM_144680	NP_653281	P17022	ZNF18_HUMAN	zinc finger protein 18	176					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)	1				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		CTCAGAAGCTCCCCAGGCCCT	0.522													---	---	---								-	11894342	-	-	11894342	7	5	289	1	0	1	0	1	0	0	0	0	17814	864	30	0	1143	0	ZNF18	17	11894342	Frame_Shift_Del	DEL	C	TCGA-DQ-7589-01A-11D-2229-08		11894342	69300868	166	53735											
LIG3	3980	broad.mit.edu	37	chr17	33329057	33329057	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgctgtgtcccgcaaggccCccagcaagccctcagccagt	7	6	10	18	1	1	0	1	0	0	0	2	0	2	0	5	1	4	3	5	1	2	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr17:33329057C>A	uc002hik.1	+	18	2716	c.2608C>A	c.(2608-2610)CCC>ACC	p.P870T	LIG3_uc002hij.2_Missense_Mutation_p.P870T	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	870					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	CCGCAAGGCCCCCAGCAAGCC	0.557								Other_BER_factors					13	38					1.37522e-17	1.87461e-17	1	0	A	33329057	A	A	33329057	3	1	289	1	0	0	0	0	1	0	0	0	8823	623	22	4	2674	4	LIG3	17	33329057	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	21434715	33329057	47866153	167	53736											
GAS2L2	246176	broad.mit.edu	37	chr17	34072965	34072965	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttgtagcaccaggaaagctCcttcctggtgttggggggcg	6	10	15	10	1	0	0	0	0	0	0	2	1	2	1	3	5	2	4	3	5	2	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr17:34072965C>A	uc002hjv.1	-	6	1579	c.1551G>T	c.(1549-1551)AGG>AGT	p.R517S		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	517					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CAGGAAAGCTCCTTCCTGGTG	0.612													22	35					1.96895e-08	2.29868e-08	1	0	A	34072965	A	A	34072965	3	1	289	1	0	0	0	0	1	0	0	0	6282	854	30	2	1095	2	GAS2L2	17	34072965	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	743908	34072965	47122245	168	53737											
CCL16	6360	broad.mit.edu	37	chr17	34304698	34304698	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaaaggtaggttgggatcCttgatgtactcttggaccca	10	11	12	8	0	1	1	0	1	1	0	2	3	2	3	2	4	2	4	2	4	3	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr17:34304698C>T	uc002hkl.2	-	3	334	c.267G>A	c.(265-267)AAG>AAA	p.K89K	CCL16_uc002hkm.2_RNA	NM_004590	NP_004581	O15467	CCL16_HUMAN	small inducible cytokine A16 precursor	89					cell-cell signaling|immune response|inflammatory response	extracellular space	chemoattractant activity|chemokine activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGTTGGGATCCTTGATGTACT	0.507													38	63					0	0	0	0	T	34304698	T	T	34304698	2	4	289	1	0	0	0	0	0	0	0	1	2900	680	24	4		4	CCL16	17	34304698	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	231733	34304698	46890512	169	53738											
NEUROD2	4761	broad.mit.edu	37	chr17	37761975	37761975	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgagcgggccctcgtactcgGagctgttgtagtccgggctc	4	10	15	12	4	0	1	0	1	0	0	4	2	1	2	2	3	3	5	2	3	2	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr17:37761975G>C	uc002hry.2	-	2	1078	c.878C>G	c.(877-879)TCC>TGC	p.S293C		NM_006160	NP_006151	Q15784	NDF2_HUMAN	neurogenic differentiation 2	293					cellular response to calcium ion|cellular response to electrical stimulus|cerebellar cortex development|negative regulation of synapse maturation|positive regulation of calcium-mediated signaling|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of synapse maturation|positive regulation of synaptic plasticity|protein ubiquitination|regulation of transcription from RNA polymerase II promoter	nucleus	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Lung(15;0.00549)|LUAD - Lung adenocarcinoma(14;0.0664)			CTCGTACTCGGAGCTGTTGTA	0.627													4	11					0	0	0	0	C	37761975	C	C	37761975	3	2	289	1	0	0	0	0	1	0	0	0	10403	1174	41	2	274	2	NEUROD2	17	37761975	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	3457277	37761975	43433235	170	53739											
EPB41L3	23136	broad.mit.edu	37	chr18	5416372	5416372	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgagtcagtgccaagcccAggtgactgatgtgaaagaga	13	7	13	8	0	1	5	1	4	0	1	1	6	1	5	2	1	2	0	2	1	2	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr18:5416372A>T	uc002kmt.1	-	13	1598	c.1512T>A	c.(1510-1512)CCT>CCA	p.P504P	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Intron|EPB41L3_uc010wzf.1_Intron|EPB41L3_uc010wzg.1_Intron|EPB41L3_uc010dkr.2_Intron	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	504	Hydrophilic.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TGCCAAGCCCAGGTGACTGAT	0.423													14	27					0	0	0	0	T	5416372	T	T	5416372	2	4	289	1	0	0	0	0	0	0	0	1	5178	175	7	5		5	EPB41L3	18	5416372	Silent	SNP	A	TCGA-DQ-7589-01A-11D-2229-08		5416372	72660876	171	53740											
SLC39A6	25800	broad.mit.edu	37	chr18	33706695	33706695	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatggtcgtggtcatggtgTatatggattcttttaatctt	7	19	11	4	1	3	1	1	1	2	0	4	2	3	2	0	4	0	1	0	4	3	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr18:33706695T>A	uc010dmy.2	-	2	566	c.276A>T	c.(274-276)ATA>ATT	p.I92I	SLC39A6_uc002kzj.2_Intron	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	92	His-rich.|Extracellular (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						ggtcatggtgTATATGGATTC	0.149													26	16					0	0	0	0	A	33706695	A	A	33706695	2	1	289	1	0	0	0	0	0	0	0	1	14686	1628	57	5		5	SLC39A6	18	33706695	Silent	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	28290323	33706695	44370553	172	53741											
SLC14A2	8170	broad.mit.edu	37	chr18	43247011	43247011	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaagggtcagcaaagccCtcagctacatcacaggagag	15	4	12	10	0	3	1	3	0	0	1	3	3	3	2	1	3	4	2	1	3	4	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr18:43247011C>A	uc010dnj.2	+	14	1990	c.1669C>A	c.(1669-1671)CTC>ATC	p.L557I	SLC14A2_uc002lbe.2_Missense_Mutation_p.L557I	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	557						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CAGCAAAGCCCTCAGCTACAT	0.473													7	27					1.26484e-09	1.49817e-09	1	0	A	43247011	A	A	43247011	3	1	289	1	0	0	0	0	1	0	0	0	14462	681	24	4	1715	4	SLC14A2	18	43247011	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	9540316	43247011	34830237	173	53742											
MAPK4	5596	broad.mit.edu	37	chr18	48190512	48190512	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgcccgcagcatgaagcacGcgctccgagagatcaagatc	12	5	11	13	4	1	3	1	1	0	2	3	5	2	3	2	0	3	4	2	0	2	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr18:48190512G>A	uc002lev.2	+	2	1184	c.184G>A	c.(184-186)GCG>ACG	p.A62T	MAPK4_uc010xdm.1_Intron|MAPK4_uc010doz.2_Missense_Mutation_p.A62T	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	62	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		CATGAAGCACGCGCTCCGAGA	0.612													19	48					0	0	0	0	A	48190512	A	A	48190512	3	1	289	1	0	0	0	0	1	0	0	0	9333	1087	38	1	186	1	MAPK4	18	48190512	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	4943501	48190512	29886736	174	53743											
DCC	1630	broad.mit.edu	37	chr18	50918220	50918220	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcgactttacaccgtccGgtggagaaccagcttttctg	7	11	12	11	3	1	1	0	0	1	1	2	3	2	1	3	3	4	1	3	3	2	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr18:50918220G>A	uc002lfe.1	+	17	3238	c.2651G>A	c.(2650-2652)CGG>CAG	p.R884Q	DCC_uc010xdr.1_Missense_Mutation_p.R712Q|DCC_uc010dpf.1_Missense_Mutation_p.R519Q	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	884	Extracellular (Potential).|Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TACACCGTCCGGTGGAGAACC	0.438													12	36					0	0	0	0	A	50918220	A	A	50918220	3	1	289	1	0	0	0	0	1	0	0	0	4299	1116	39	1	2717	1	DCC	18	50918220	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	2727708	50918220	27159028	175	53744											
NFATC1	4772	broad.mit.edu	37	chr18	77246788	77246788	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgggccgcccgcagcaccTgccgtccacggtccgcaggg	5	3	14	19	6	0	0	0	0	0	0	2	0	2	0	6	3	2	3	6	3	0	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr18:77246788T>A	uc010xfg.1	+	9	3086	c.2633T>A	c.(2632-2634)CTG>CAG	p.L878Q	NFATC1_uc002lnd.2_Intron|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Intron|NFATC1_uc010xfj.1_Missense_Mutation_p.L406Q|NFATC1_uc002lnf.2_Missense_Mutation_p.L865Q|NFATC1_uc002lng.2_Intron|NFATC1_uc010xfk.1_Intron	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	878	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CCGCAGCACCTGCCGTCCACG	0.701													15	40					0	0	0	0	A	77246788	A	A	77246788	3	1	289	1	0	0	0	0	1	0	0	0	10415	1580	55	5	2818	5	NFATC1	18	77246788	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	26328568	77246788	830460	176	53745											
PLIN4	729359	broad.mit.edu	37	chr19	4510708	4510709	+	Frame_Shift_Ins	INS	-	GGGG	GGGG																															gcgtggagatgccagagaacINSggggcctcttgggggctcag																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:4510708_4510709insGGGG	uc002mar.1	-	3	3221_3222	c.3221_3222insCCCC	c.(3220-3222)CCGfs	p.P1074fs	PLIN4_uc010dub.1_Frame_Shift_Ins_p.P98fs	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	1074						lipid particle|plasma membrane					0						TGCCAGAGAACGGGGCCTCTTG	0.653													---	---	---								GGGG	4510709	GGGG	GGGG	4510708	7	5	289	1	0	1	1	0	0	0	0	0	12147	523	19	0	867	0	PLIN4	19	4510708	Frame_Shift_Ins	INS	-	TCGA-DQ-7589-01A-11D-2229-08		4510708	54618275	177	53746											
TMEM146	257062	broad.mit.edu	37	chr19	5754157	5754159	+	In_Frame_Del	DEL	AGG	-	-																															aactagatagagtttctgacAggagaatttatatacaggat																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:5754157_5754159delAGG	uc002mda.2	+	13	1240_1242	c.1179_1181delAGG	c.(1177-1182)ACAGGA>ACA	p.G394del	TMEM146_uc010duj.1_In_Frame_Del_p.G52del	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	394	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGTTTCTGACAGGAGAATTTATA	0.458													---	---	---								-	5754159	-	-	5754157	7	5	289	1	0	1	0	1	0	0	0	0	16126	175	7	0	1229	0	TMEM146	19	5754157	In_Frame_Del	DEL	AGG	TCGA-DQ-7589-01A-11D-2229-08	1243449	5754157	53374826	178	53747											
OR7G1	125962	broad.mit.edu	37	chr19	9226160	9226161	+	Frame_Shift_Del	DEL	AA	-	-																															ctgggtgaggcagcctgtgtAagtgatactctgattctgag																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:9226160_9226161delAA	uc002mks.1	-	1	279_280	c.279_280delTT	c.(277-282)ACTTACfs	p.T93fs		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	93_94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						CAGCCTGTGTAAGTGATACTCT	0.455													---	---	---								-	9226161	-	-	9226160	7	5	289	1	0	1	0	1	0	0	0	0	11276	362	13	0	729	0	OR7G1	19	9226160	Frame_Shift_Del	DEL	AA	TCGA-DQ-7589-01A-11D-2229-08	3472003	9226160	49902823	179	53748											
KEAP1	9817	broad.mit.edu	37	chr19	10602473	10602473	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtacaacagcccgcccaccaCgcagccggccaggccgctcc	8	2	10	21	4	0	0	0	0	0	0	1	0	1	0	7	2	4	3	7	2	2	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:10602473C>T	uc002moq.1	-	3	1261	c.1105G>A	c.(1105-1107)GTG>ATG	p.V369M	KEAP1_uc002mop.1_Missense_Mutation_p.V87M|KEAP1_uc002mor.1_Missense_Mutation_p.V369M	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	369	Kelch 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCGCCCACCACGCAGCCGGCC	0.677													4	2					0	0	0	0	T	10602473	T	T	10602473	3	4	289	1	0	0	0	0	1	0	0	0	8180	536	19	1	785	1	KEAP1	19	10602473	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	1376313	10602473	48526510	180	53749											
DOCK6	57572	broad.mit.edu	37	chr19	11327707	11327707	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggctcggtgtttttcagcacCcacagcacacacgccagcaa	10	7	9	15	2	1	0	1	0	0	0	2	0	1	0	2	2	3	5	2	2	1	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:11327707C>T	uc002mqs.3	-	30	3818	c.3777G>A	c.(3775-3777)TGG>TGA	p.W1259*	DOCK6_uc010xlq.1_Nonsense_Mutation_p.W598*	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1259					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TTTTCAGCACCCACAGCACAC	0.597													19	20					0	0	0	0	T	11327707	T	T	11327707	4	4	289	1	0	0	0	0	0	1	0	0	4713	624	22	4	2442	4	DOCK6	19	11327707	Nonsense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	725234	11327707	47801276	181	53750											
CHERP	10523	broad.mit.edu	37	chr19	16630505	16630505	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggatgggaggcgccgaattAgaacccagaccagcagagga	13	3	16	9	2	0	3	0	0	0	3	0	7	0	6	3	4	2	1	3	4	3	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:16630505A>T	uc002nei.1	-	16	2558	c.2484T>A	c.(2482-2484)TCT>TCA	p.S828S	MED26_uc002nee.2_Intron|C19orf44_uc002neh.1_Intron|C19orf44_uc010eai.1_Intron|CHERP_uc010xpg.1_Silent_p.S367S	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	828					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GCGCCGAATTAGAACCCAGAC	0.502													54	121					0	0	0	0	T	16630505	T	T	16630505	2	4	289	1	0	0	0	0	0	0	0	1	3351	407	15	5		5	CHERP	19	16630505	Silent	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	5302798	16630505	42498478	182	53751											
KCNN1	3780	broad.mit.edu	37	chr19	18084926	18084926	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggatgatgaggaagatgagGccggcaggcagagagcctcg	12	4	18	7	2	0	5	0	3	0	2	1	8	0	7	2	5	1	2	2	5	1	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:18084926G>T	uc002nht.2	+	3	539	c.229G>T	c.(229-231)GCC>TCC	p.A77S	KCNN1_uc010xqa.1_Missense_Mutation_p.A77S	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	77					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						GGAAGATGAGGCCGGCAGGCA	0.687													16	28					2.37509e-13	3.06626e-13	1	0	T	18084926	T	T	18084926	3	4	289	1	0	0	0	0	1	0	0	0	8117	1203	42	4	231	4	KCNN1	19	18084926	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	1454421	18084926	41044057	183	53752											
ZNF429	353088	broad.mit.edu	37	chr19	21713485	21713485	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatggtggatgaacccccAggtaggtgagagtgaacaca	14	6	14	7	0	0	3	0	3	0	1	0	6	0	4	2	4	2	1	2	4	4	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:21713485A>T	uc002nqd.1	+	3	362	c.225A>T	c.(223-225)CCA>CCT	p.P75P	ZNF429_uc010ecu.1_Silent_p.P75P	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	75	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ATGAACCCCCAGGTAGGTGAG	0.433													13	26					0	0	0	0	T	21713485	T	T	21713485	2	4	289	1	0	0	0	0	0	0	0	1	17969	202	7	5		5	ZNF429	19	21713485	Silent	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	3628559	21713485	37415498	184	53753											
TSHZ3	57616	broad.mit.edu	37	chr19	31769772	31769772	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attttggcggcgacaggagtGacgggttccttcagaggcac	8	9	15	9	3	1	2	1	1	0	1	2	4	2	3	1	5	0	2	1	5	0	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:31769772G>T	uc002nsy.3	-	2	992	c.927C>A	c.(925-927)GTC>GTA	p.V309V		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	309					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CGACAGGAGTGACGGGTTCCT	0.532													20	33					1.33834e-09	1.57756e-09	1	0	T	31769772	T	T	31769772	2	4	289	1	0	0	0	0	0	0	0	1	16692	1277	45	2		2	TSHZ3	19	31769772	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	10056287	31769772	27359211	185	53754											
SPTBN4	57731	broad.mit.edu	37	chr19	41077931	41077931	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcttgtcgctccaggtcgtgGgtgagcctgtactgtgtgct	3	14	14	10	2	1	1	0	1	1	0	4	1	2	1	2	2	3	3	2	2	1	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:41077931G>C	uc002ony.2	+	34	7412	c.7326G>C	c.(7324-7326)TGG>TGC	p.W2442C	SPTBN4_uc002onz.2_Missense_Mutation_p.W2442C|SPTBN4_uc010egx.2_Missense_Mutation_p.W1185C	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	2442	PH.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCAGGTCGTGGGTGAGCCTGT	0.562													93	377					0	0	0	0	C	41077931	C	C	41077931	3	2	289	1	0	0	0	0	1	0	0	0	15187	1241	43	4	7550	4	SPTBN4	19	41077931	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	9308159	41077931	18051052	186	53755											
ZNF285	26974	broad.mit.edu	37	chr19	44891894	44891895	+	Missense_Mutation	DNP	CA	AT	AT																															cgtctgtacaatttctcttcCatgtaaattcccttatatct																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:44891894_44891895CA>AT	uc002ozd.3	-	4	599_600	c.512_513TG>AT	c.(511-513)ATG>AAT	p.M171N	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.M178N	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						ATTTCTCTTCCATGTAAATTCC	0.475													28	53					0	0	0	0	AT	44891895	AT	AT	44891894	3	1	289	1	0	0	0	0	1	0	0	0	17889	594	21	4	1263	4	ZNF285	19	44891894	Missense_Mutation	DNP	CA	TCGA-DQ-7589-01A-11D-2229-08	3813963	44891894	14237089	187	53756											
EXOC3L2	90332	broad.mit.edu	37	chr19	45735052	45735052	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgacgcattcatcctccaaaCcccgcagggtgccaggggag	9	6	12	14	2	1	1	1	1	0	0	3	2	3	2	5	3	2	2	5	3	1	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:45735052C>G	uc002pay.1	-	2	100	c.59G>C	c.(58-60)GGT>GCT	p.G20A		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	20										ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		ATCCTCCAAACCCCGCAGGGT	0.607													30	38					0	0	0	0	G	45735052	G	G	45735052	3	3	289	1	0	0	0	0	1	0	0	0	5329	507	18	4	1206	4	EXOC3L2	19	45735052	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	843158	45735052	13393931	188	53757											
CD33	945	broad.mit.edu	37	chr19	51729135	51729135	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaacctgacctgctctgtGtcctgggcctgtgagcaggg	8	9	13	11	0	1	2	0	2	1	0	2	2	2	2	4	2	3	2	4	2	2	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:51729135G>T	uc002pwa.2	+	3	535	c.495G>T	c.(493-495)GTG>GTT	p.V165V	CD33_uc010eos.1_Silent_p.V165V|CD33_uc010eot.1_Silent_p.V38V|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	165	Extracellular (Potential).|Ig-like C2-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CCTGCTCTGTGTCCTGGGCCT	0.592													32	108					2.87052e-16	3.86965e-16	1	0	T	51729135	T	T	51729135	2	4	289	1	0	0	0	0	0	0	0	1	3020	1364	48	4		4	CD33	19	51729135	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	5994083	51729135	7399848	189	53758											
FPR1	2357	broad.mit.edu	37	chr19	52249772	52249772	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagtcacacgaatgataactGgcaatgtgaggagcagagcc	14	7	12	8	1	1	3	1	2	0	1	1	5	1	4	1	2	3	2	1	2	4	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:52249772G>A	uc002pxq.2	-	2	571	c.476C>T	c.(475-477)CCA>CTA	p.P159L		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	159	Helical; Name=4; (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	AATGATAACTGGCAATGTGAG	0.532													16	44					0	0	0	0	A	52249772	A	A	52249772	3	1	289	1	0	0	0	0	1	0	0	0	6072	1348	47	4	580	4	FPR1	19	52249772	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	520637	52249772	6879211	190	53759											
ZNF578	147660	broad.mit.edu	37	chr19	53014964	53014964	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcatcagtcaagccttgcaCgtcatcatagacttcatact	11	13	5	12	1	6	1	6	0	0	1	6	1	6	1	1	0	3	1	1	0	3	5			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:53014964C>A	uc002pzp.3	+	6	1574	c.1330C>A	c.(1330-1332)CGT>AGT	p.R444S		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	219	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		AAGCCTTGCACGTCATCATAG	0.378													8	32					0.000157383	0.000168428	1	0	A	53014964	A	A	53014964	3	1	289	1	0	0	0	0	1	0	0	0	18077	536	19	3	1340	3	ZNF578	19	53014964	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	765192	53014964	6114019	191	53760											
ZNF761	388561	broad.mit.edu	37	chr19	53959845	53959845	+	Missense_Mutation	SNP	G	T	T																															accttataagtgtaatgagtGtggcaagaactttagtcaga																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:53959845G>T	uc010eqp.2	+	7	2542	c.2084G>T	c.(2083-2085)TGT>TTT	p.C695F	ZNF761_uc010ydy.1_Missense_Mutation_p.C641F|ZNF761_uc002qbt.1_Missense_Mutation_p.C641F	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	695	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TGTAATGAGTGTGGCAAGAAC	0.388													24	53					6.36457e-07	7.15648e-07	1	0	T	53959845	T	T	53959845	3	4	289	1	0	0	0	0	1	0	0	0	18203	1377	48	4	2095	4	ZNF761	19	53959845	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	944881	53959845	5169138	192	53761	124	2									
ZNF761	388561	broad.mit.edu	37	chr19	53959847	53959847	+	Missense_Mutation	SNP	G	T	T																															cttataagtgtaatgagtgtGgcaagaactttagtcagaag																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:53959847G>T	uc010eqp.2	+	7	2544	c.2086G>T	c.(2086-2088)GGC>TGC	p.G696C	ZNF761_uc010ydy.1_Missense_Mutation_p.G642C|ZNF761_uc002qbt.1_Missense_Mutation_p.G642C	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	696	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TAATGAGTGTGGCAAGAACTT	0.393													24	54					4.72057e-08	5.43311e-08	1	0	T	53959847	T	T	53959847	3	4	289	1	0	0	0	0	1	0	0	0	18203	1348	47	4	2097	4	ZNF761	19	53959847	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	2	53959847	5169136	193	53762	124	2									
EPN1	29924	broad.mit.edu	37	chr19	56206686	56206686	+	Frame_Shift_Del	DEL	C	-	-																															ccccccatgatgcccccgggCcccccggcccccaacactaa																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr19:56206686delC	uc002qlw.2	+	11	2037	c.1695delC	c.(1693-1695)GGCfs	p.G565fs	EPN1_uc002qlv.2_Frame_Shift_Del_p.G539fs|EPN1_uc010etd.2_Frame_Shift_Del_p.G564fs|EPN1_uc002qlx.2_Frame_Shift_Del_p.G651fs	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	565	Ala/Gly/Pro-rich.|3 X 3 AA repeats of N-P-F.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		Tgcccccgggccccccggccc	0.582													---	---	---								-	56206686	-	-	56206686	7	5	289	1	0	1	0	1	0	0	0	0	5209	726	26	0	2074	0	EPN1	19	56206686	Frame_Shift_Del	DEL	C	TCGA-DQ-7589-01A-11D-2229-08	2246839	56206686	2922297	194	53763											
NINL	22981	broad.mit.edu	37	chr20	25439125	25439125	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccggacctcctgcaagtgcTgggcctgggcctgcctcagc	4	7	14	16	1	1	0	1	0	0	0	2	1	2	1	6	3	4	2	6	3	1	0	rs116267316	byFrequency	TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr20:25439125T>C	uc002wux.1	-	22	3811	c.3737A>G	c.(3736-3738)CAG>CGG	p.Q1246R	NINL_uc010gdn.1_Missense_Mutation_p.Q897R|NINL_uc002wuw.1_Missense_Mutation_p.Q37R	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1246	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CTGCAAGTGCTGGGCCTGGGC	0.687													5	10					0	0	0	0	C	25439125	C	C	25439125	3	2	289	1	0	0	0	0	1	0	0	0	10474	1580	55	5	423	5	NINL	20	25439125	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08		25439125	37586395	195	53764											
NINL	22981	broad.mit.edu	37	chr20	25477376	25477376	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaactccaggttcctcttCtcggccctctccaggtcctg	6	11	7	17	1	3	0	0	0	3	0	8	0	6	0	5	3	1	1	5	3	1	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr20:25477376C>T	uc002wux.1	-	10	1307	c.1233G>A	c.(1231-1233)GAG>GAA	p.E411E	NINL_uc010gdn.1_Silent_p.E411E|NINL_uc010gdo.1_Silent_p.E194E|NINL_uc010ztf.1_Silent_p.E427E	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	411	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GGTTCCTCTTCTCGGCCCTCT	0.602													11	52					0	0	0	0	T	25477376	T	T	25477376	2	4	289	1	0	0	0	0	0	0	0	1	10474	912	32	2		2	NINL	20	25477376	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	38251	25477376	37548144	196	53765											
DEFB118	117285	broad.mit.edu	37	chr20	29960861	29960861	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tattgatgatattttaacagTaaggttcacgacagactact	14	14	7	6	1	1	3	1	2	0	1	1	4	1	3	0	1	2	2	0	1	5	8			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr20:29960861T>A	uc002wvr.2	+	2	286	c.260T>A	c.(259-261)GTA>GAA	p.V87E		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	87					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			ATTTTAACAGTAAGGTTCACG	0.458													51	54					0	0	0	0	A	29960861	A	A	29960861	3	1	289	1	0	0	0	0	1	0	0	0	4427	1638	57	5	266	5	DEFB118	20	29960861	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	4483485	29960861	33064659	197	53766											
C20orf132	140699	broad.mit.edu	37	chr20	35783537	35783537	+	Frame_Shift_Del	DEL	G	-	-																															cgtggcccgttcccgctcatGgtctttgactgactgtaacc																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr20:35783537delG	uc010zvu.1	-	11	1124	c.1033delC	c.(1033-1035)CATfs	p.H345fs	C20orf132_uc002xgk.2_Intron|C20orf132_uc002xgm.2_Frame_Shift_Del_p.H345fs|C20orf132_uc002xgn.2_Intron	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Myeloproliferative disorder(115;0.00878)				TCCCGCTCATGGTCTTTGACT	0.493													---	---	---								-	35783537	-	-	35783537	7	5	289	1	0	1	0	1	0	0	0	0	2096	1348	47	0	2201	0	C20orf132	20	35783537	Frame_Shift_Del	DEL	G	TCGA-DQ-7589-01A-11D-2229-08	5822676	35783537	27241983	198	53767											
PTPRT	11122	broad.mit.edu	37	chr20	40979284	40979284	+	Frame_Shift_Del	DEL	G	-	-																															tcacctgacaggagctccccGggactgagcgggtttcagca																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr20:40979284delG	uc002xkg.2	-	11	2033	c.1849delC	c.(1849-1851)CGGfs	p.R617fs	PTPRT_uc010ggj.2_Frame_Shift_Del_p.R617fs	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	617	Extracellular (Potential).|Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGAGCTCCCCGGGACTGAGCG	0.527													---	---	---								-	40979284	-	-	40979284	7	5	289	1	0	1	0	1	0	0	0	0	12877	1115	39	0	2621	0	PTPRT	20	40979284	Frame_Shift_Del	DEL	G	TCGA-DQ-7589-01A-11D-2229-08	5195747	40979284	22046236	199	53768											
PHACTR3	116154	broad.mit.edu	37	chr20	58318232	58318232	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attcgaactccccctgtgagGaggaacagcaaactggccac	12	6	10	13	1	0	1	0	1	0	0	2	4	1	3	3	3	4	1	3	3	3	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr20:58318232G>T	uc002yau.2	+	2	656	c.189G>T	c.(187-189)AGG>AGT	p.R63S	PHACTR3_uc002yat.2_Missense_Mutation_p.R60S|PHACTR3_uc010zzw.1_Missense_Mutation_p.R22S|PHACTR3_uc002yav.2_Missense_Mutation_p.R22S|PHACTR3_uc002yaw.2_Missense_Mutation_p.R22S|PHACTR3_uc002yax.2_Missense_Mutation_p.R22S	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	63						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CCCCTGTGAGGAGGAACAGCA	0.527													12	55					0.00136819	0.00142666	1	0	T	58318232	T	T	58318232	3	4	289	1	0	0	0	0	1	0	0	0	11866	1165	41	2	195	2	PHACTR3	20	58318232	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	17338948	58318232	4707288	200	53769											
SAMSN1	64092	broad.mit.edu	37	chr21	15872961	15872961	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcttctgagatgacatcCacataaatgaatttgaagtt	13	14	6	8	0	2	4	0	4	2	1	4	5	4	4	2	0	0	1	2	0	4	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr21:15872961C>G	uc002yju.1	-	6	739	c.657G>C	c.(655-657)GTG>GTC	p.V219V	SAMSN1_uc010gky.1_Silent_p.V51V|SAMSN1_uc002yjv.1_Silent_p.V287V	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	219	SH3.				negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		AGATGACATCCACATAAATGA	0.408													19	77					0	0	0	0	G	15872961	G	G	15872961	2	3	289	1	0	0	0	0	0	0	0	1	13895	581	21	4		4	SAMSN1	21	15872961	Silent	SNP	C	TCGA-DQ-7589-01A-11D-2229-08		15872961	32256934	201	53770											
IFNGR2	3460	broad.mit.edu	37	chr21	34787228	34787228	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcccgctcctcagcaccCgaagattcgcctgtacaacg	8	7	9	17	4	1	1	1	0	0	1	3	2	2	1	4	0	4	4	4	0	3	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr21:34787228C>A	uc002yrp.3	+	2	755	c.107C>A	c.(106-108)CCG>CAG	p.P36Q	IFNGR2_uc002yrq.3_Missense_Mutation_p.P55Q|IFNGR2_uc010gma.2_5'UTR|IFNGR2_uc002yrr.3_5'UTR	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	36	Extracellular (Potential).|Fibronectin type-III 1.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	CCTCAGCACCCGAAGATTCGC	0.393													16	18					6.72482e-11	8.24551e-11	1	0	A	34787228	A	A	34787228	3	1	289	1	0	0	0	0	1	0	0	0	7589	652	23	3	113	3	IFNGR2	21	34787228	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	18914267	34787228	13342667	202	53771											
KCNJ6	3763	broad.mit.edu	37	chr21	39087393	39087393	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctggtgaatggccactgggcTttcgacgtcctgatccatgg	6	11	13	11	2	0	2	0	2	0	0	3	3	2	2	3	4	0	1	3	4	1	1			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr21:39087393T>C	uc011aej.1	-	3	120	c.67A>G	c.(67-69)AGC>GGC	p.S23G	KCNJ6_uc002ywo.2_Missense_Mutation_p.S23G	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	23	Cytoplasmic (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	GCCACTGGGCTTTCGACGTCC	0.517													5	18					0	0	0	0	C	39087393	C	C	39087393	3	2	289	1	0	0	0	0	1	0	0	0	8094	1609	56	5	1212	5	KCNJ6	21	39087393	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08	4300165	39087393	9042502	203	53772											
TBC1D10A	83874	broad.mit.edu	37	chr22	30690945	30690945	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtacctcagcaggcatatgCatgagcaagacagcggcaat	13	6	12	10	1	1	2	1	1	0	1	1	2	1	2	1	3	5	6	1	3	4	2	rs143051895		TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr22:30690945C>A	uc011akt.1	-	5	648	c.624G>T	c.(622-624)ATG>ATT	p.M208I	GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_RNA|GATSL3_uc003ahh.2_RNA|GATSL3_uc010gvq.2_RNA|GATSL3_uc003ahi.2_Missense_Mutation_p.M66I|TBC1D10A_uc003ahj.3_Missense_Mutation_p.M120I|TBC1D10A_uc010gvu.2_Missense_Mutation_p.M215I|TBC1D10A_uc003ahk.3_Missense_Mutation_p.M208I	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	208	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CAGGCATATGCATGAGCAAGA	0.662													42	125					1.67211e-32	2.42854e-32	1	0	A	30690945	A	A	30690945	3	1	289	1	0	0	0	0	1	0	0	0	15664	710	25	4	922	4	TBC1D10A	22	30690945	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08		30690945	20613621	204	53773											
CSF2RB	1439	broad.mit.edu	37	chr22	37333864	37333864	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtccctccctggagtccgggGgaggccctgcccctcctgct	2	8	13	18	1	0	0	0	0	0	0	4	2	4	2	7	4	2	1	7	4	0	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr22:37333864G>A	uc003aqa.3	+	14	2231	c.2014G>A	c.(2014-2016)GGA>AGA	p.G672R	CSF2RB_uc003aqc.3_Missense_Mutation_p.G678R	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	672	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	GGAGTCCGGGGGAGGCCCTGC	0.672													6	6					0	0	0	0	A	37333864	A	A	37333864	3	1	289	1	0	0	0	0	1	0	0	0	3952	1233	43	4	2064	4	CSF2RB	22	37333864	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	6642919	37333864	13970702	205	53774											
FAM116B	414918	broad.mit.edu	37	chr22	50754808	50754808	+	Frame_Shift_Del	DEL	G	-	-																															tggccactcacctgcttccaGgcagggcgccagcttgtcaa																										TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr22:50754808delG	uc011aru.1	-	7	622	c.550delC	c.(550-552)CTGfs	p.L184fs	FAM116B_uc011arv.1_Frame_Shift_Del_p.L184fs	NM_001001794	NP_001001794	Q8NEG7	F116B_HUMAN	family with sequence similarity 116, member B	184											0		all_cancers(38;4.34e-09)|all_epithelial(38;3.03e-08)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCTGCTTCCAGGCAGGGCGCC	0.632													---	---	---								-	50754808	-	-	50754808	7	5	289	1	0	1	0	1	0	0	0	0	5436	991	35	0	1267	0	FAM116B	22	50754808	Frame_Shift_Del	DEL	G	TCGA-DQ-7589-01A-11D-2229-08	13420944	50754808	549758	206	53775											
MAPK8IP2	23542	broad.mit.edu	37	chr22	51041670	51041670	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggacagcctctccctggggCgctcggagcagccgcacccc	6	4	13	18	3	1	0	0	0	1	0	3	2	1	2	5	4	3	3	5	4	0	0			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chr22:51041670C>G	uc003bmx.2	+	3	307	c.190C>G	c.(190-192)CGC>GGC	p.R64G	MAPK8IP2_uc003bmy.2_Missense_Mutation_p.R37G|MAPK8IP2_uc011asc.1_5'Flank	NM_012324	NP_036456	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting	64					behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			large_intestine(2)|central_nervous_system(1)	3		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTCCCTGGGGCGCTCGGAGCA	0.532													18	13					0	0	0	0	G	51041670	G	G	51041670	3	3	289	1	0	0	0	0	1	0	0	0	9338	768	27	3	290	3	MAPK8IP2	22	51041670	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	286862	51041670	262896	207	53776											
TIMP1	7076	broad.mit.edu	37	chrX	47442836	47442836	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggccccctttgagcccctgGcttctggcatcctgttgttg	2	14	11	14	0	1	1	0	1	1	0	2	1	2	1	5	3	1	4	5	3	0	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chrX:47442836G>A	uc004dif.2	+	2	214	c.22G>A	c.(22-24)GCT>ACT	p.A8T	SYN1_uc004did.2_Intron|SYN1_uc004die.2_Intron|TIMP1_uc011mlr.1_5'UTR|TIMP1_uc010nht.1_5'UTR	NM_003254	NP_003245	P01033	TIMP1_HUMAN	tissue inhibitor of metalloproteinase 1	8					erythrocyte maturation|negative regulation of membrane protein ectodomain proteolysis|platelet activation|platelet degranulation|positive regulation of cell proliferation	platelet alpha granule lumen	metal ion binding|metalloendopeptidase inhibitor activity|protein binding				0						TGAGCCCCTGGCTTCTGGCAT	0.657													15	51					0	0	0	0	A	47442836	A	A	47442836	3	1	289	1	0	0	0	0	1	0	0	0	15983	1203	42	4	24	4	TIMP1	23	47442836	Missense_Mutation	SNP	G	TCGA-DQ-7589-01A-11D-2229-08		47442836	107827724	208	53777											
FTSJ1	24140	broad.mit.edu	37	chrX	48337083	48337083	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtgtggtacagatccagggGgacatcacccaggtaagagc	11	6	15	9	0	1	2	1	0	0	2	2	3	2	3	2	5	2	2	2	5	2	2	rs138008946	byFrequency	TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chrX:48337083G>T	uc004djo.1	+	4	593	c.270G>T	c.(268-270)GGG>GGT	p.G90G	FTSJ1_uc004djl.2_Silent_p.G90G|FTSJ1_uc004djm.2_Silent_p.G90G|FTSJ1_uc004djn.1_Silent_p.G90G|FTSJ1_uc004djp.1_Silent_p.G90G|FTSJ1_uc011mlw.1_Intron	NM_012280	NP_036412	Q9UET6	RRMJ1_HUMAN	FtsJ homolog 1 isoform a	90					RNA methylation|rRNA processing		methyltransferase activity|nucleic acid binding				0						AGATCCAGGGGGACATCACCC	0.532													4	15					3.59834e-05	3.95493e-05	1	0	T	48337083	T	T	48337083	2	4	289	1	0	0	0	0	0	0	0	1	6121	1219	43	4		4	FTSJ1	23	48337083	Silent	SNP	G	TCGA-DQ-7589-01A-11D-2229-08	894247	48337083	106933477	209	53778											
PLP2	5355	broad.mit.edu	37	chrX	49029528	49029528	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgcctccacaccaggctactCctccctgtcggtgattgaga	7	10	9	15	1	0	2	0	2	0	1	4	3	3	2	5	2	2	1	5	2	1	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chrX:49029528C>T	uc004dmx.2	+	2	224	c.149C>T	c.(148-150)TCC>TTC	p.S50F		NM_002668	NP_002659	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic	50	Helical; (Potential).|MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity				0						CCAGGCTACTCCTCCCTGTCG	0.507													14	3					0	0	0	0	T	49029528	T	T	49029528	3	4	289	1	0	0	0	0	1	0	0	0	12160	855	30	2	155	2	PLP2	23	49029528	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	692445	49029528	106241032	210	53779											
SHROOM4	57477	broad.mit.edu	37	chrX	50376610	50376610	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggtccatgggatggcgcctCaattccctacagctggagct	7	10	12	12	1	1	0	1	0	0	0	3	2	3	2	3	4	3	2	3	4	2	2			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chrX:50376610C>A	uc004dpe.2	-	4	2489	c.2463G>T	c.(2461-2463)TTG>TTT	p.L821F	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.L705F	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	821					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GATGGCGCCTCAATTCCCTAC	0.458													26	74					1.04121e-07	1.19275e-07	1	0	A	50376610	A	A	50376610	3	1	289	1	0	0	0	0	1	0	0	0	14361	825	29	2	2042	2	SHROOM4	23	50376610	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	1347082	50376610	104893950	211	53780											
TEX11	56159	broad.mit.edu	37	chrX	69945165	69945165	+	Nonsense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcaagaggattttcatttttAagaaaagcccaggagaactt	15	12	8	6	0	2	3	2	0	0	3	2	5	2	4	1	2	2	0	1	2	5	6			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chrX:69945165A>C	uc004dyl.2	-	13	1079	c.917T>G	c.(916-918)TTA>TGA	p.L306*	TEX11_uc004dyk.2_5'Flank|TEX11_uc004dym.2_Nonsense_Mutation_p.L291*	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	306							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					TTTCATTTTTAAGAAAAGCCC	0.318													12	46					0	0	0	0	C	69945165	C	C	69945165	4	2	289	1	0	0	0	0	0	1	0	0	15840	372	13	5	1981	5	TEX11	23	69945165	Nonsense_Mutation	SNP	A	TCGA-DQ-7589-01A-11D-2229-08	19568555	69945165	85325395	212	53781											
CDR1	1038	broad.mit.edu	37	chrX	139865950	139865950	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atatatgtcttcctgaagatCcacgtcttccagaaaatcca	13	12	5	11	1	2	3	0	1	2	2	6	3	6	3	4	0	0	0	4	0	5	4			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chrX:139865950C>G	uc004fbg.1	-	1	774	c.582G>C	c.(580-582)TGG>TGC	p.W194C	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	194	5 X 6 AA approximate repeats.|3.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				TCCTGAAGATCCACGTCTTCC	0.438													17	75					0	0	0	0	G	139865950	G	G	139865950	3	3	289	1	0	0	0	0	1	0	0	0	3186	856	30	2	210	2	CDR1	23	139865950	Missense_Mutation	SNP	C	TCGA-DQ-7589-01A-11D-2229-08	69920785	139865950	15404610	213	53782											
USP9Y	8287	broad.mit.edu	37	chrY	14958426	14958426	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaatgtgtcatcaacaaTgcagtcttcaatcaatggta	13	13	7	8	0	5	0	4	0	1	0	5	0	5	0	0	1	3	3	0	1	6	3			TCGA-DQ-7589-01A-11D-2229-08	TCGA-DQ-7589-10C-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	de34e28e-942b-442b-b745-7f2a0e56f3ff	8b0f925a-eac1-4d07-981f-3fd48e8006f3	g.chrY:14958426T>C	uc004fst.1	+	40	7682	c.6737T>C	c.(6736-6738)ATG>ACG	p.M2246T	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	2246					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						TCATCAACAATGCAGTCTTCA	0.363													35	17					0	0	0	0	C	14958426	C	C	14958426	3	2	289	1	0	0	0	0	1	0	0	0	17159	1464	51	5	6887	5	USP9Y	24	14958426	Missense_Mutation	SNP	T	TCGA-DQ-7589-01A-11D-2229-08		14958426	44415140	214	53783											
HTR1D	3352	broad.mit.edu	37	chr1	23519918	23519918	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaggggagccagccgagtgCgagtgcccctcatggaggct	8	5	17	11	2	1	1	1	0	0	1	1	5	1	3	4	4	4	1	4	4	0	0			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr1:23519918C>T	uc001bgn.2	-	1	1305	c.795G>A	c.(793-795)TCG>TCA	p.S265S		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	265	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	CAGCCGAGTGCGAGTGCCCCT	0.582													24	78					0	0	0	0	T	23519918	T	T	23519918	2	4	290	1	0	0	0	0	0	0	0	1	7477	755	27	1		1	HTR1D	1	23519918	Silent	SNP	C	TCGA-DQ-7590-01A-11D-2229-08		23519918	225730703	1	53784											
SYNC	81493	broad.mit.edu	37	chr1	33149861	33149861	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atagcagcagaaactgacttAtaagtagagagctcttcagc	15	9	9	8	0	2	3	1	1	1	2	2	4	2	3	0	0	5	4	0	0	5	5			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr1:33149861A>G	uc001bvt.2	-	3	1456	c.1356T>C	c.(1354-1356)TAT>TAC	p.Y452Y	SYNC_uc010ohl.1_Silent_p.Y452Y|RBBP4_uc001bvr.2_3'UTR|RBBP4_uc001bvs.2_3'UTR|RBBP4_uc010ohj.1_3'UTR|RBBP4_uc010ohk.1_3'UTR	NM_030786	NP_110413	Q9H7C4	SYNCI_HUMAN	syncoilin, intermediate filament 1 isoform 1	452	Coil 2.					intermediate filament|perinuclear region of cytoplasm	structural molecule activity			ovary(1)	1						AAACTGACTTATAAGTAGAGA	0.428													106	259					0	0	0	0	G	33149861	G	G	33149861	2	3	290	1	0	0	0	0	0	0	0	1	15509	456	16	5		5	SYNC	1	33149861	Silent	SNP	A	TCGA-DQ-7590-01A-11D-2229-08	9629943	33149861	216100760	2	53785											
HPDL	84842	broad.mit.edu	37	chr1	45793539	45793539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccttccgggggcgacgacacGacaggaccaggtggagcagt	9	4	16	12	4	0	0	0	0	0	0	1	5	1	2	3	5	1	1	3	5	0	1			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr1:45793539G>A	uc001cne.2	+	1	995	c.719G>A	c.(718-720)CGA>CAA	p.R240Q		NM_032756	NP_116145	Q96IR7	HPDL_HUMAN	glyoxalase domain containing 1	240					aromatic amino acid family metabolic process		4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	Acute lymphoblastic leukemia(166;0.155)					GCGACGACACGACAGGACCAG	0.652													33	116					0	0	0	0	A	45793539	A	A	45793539	3	1	290	1	0	0	0	0	1	0	0	0	7372	1058	37	1	721	1	HPDL	1	45793539	Missense_Mutation	SNP	G	TCGA-DQ-7590-01A-11D-2229-08	12643678	45793539	203457082	3	53786											
CCDC76	54482	broad.mit.edu	37	chr1	100613819	100613819	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaagataatcagaatgatgAtagtgaagagcatgatgatg	17	9	12	3	0	1	8	1	5	0	3	1	8	1	8	0	0	1	2	0	0	5	2			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr1:100613819A>G	uc001dsv.2	+	10	1206	c.1187A>G	c.(1186-1188)GAT>GGT	p.D396G	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Intron	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	396					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		CAGAATGATGATAGTGAAGAG	0.408													36	90					0	0	0	0	G	100613819	G	G	100613819	3	3	290	1	0	0	0	0	1	0	0	0	2863	333	12	5	1225	5	CCDC76	1	100613819	Missense_Mutation	SNP	A	TCGA-DQ-7590-01A-11D-2229-08	54820280	100613819	148636802	4	53787											
KPRP	448834	broad.mit.edu	37	chr1	152733723	152733724	+	Frame_Shift_Ins	INS	-	C	C																															ctggtgatgtgtttccagagINScggaggggtcaggatggcca																										TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr1:152733723_152733724insC	uc001fal.1	+	2	1717_1718	c.1659_1660insC	c.(1657-1662)GAGCGGfs	p.E553fs		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	553_554						cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTTTCCAGAGCGGAGGGGTCA	0.54													---	---	---								C	152733724	C	C	152733723	7	5	290	1	0	1	1	0	0	0	0	0	8475	962	34	0	1661	0	KPRP	1	152733723	Frame_Shift_Ins	INS	-	TCGA-DQ-7590-01A-11D-2229-08	52119904	152733723	96516898	5	53788											
PEAR1	375033	broad.mit.edu	37	chr1	156878077	156878077	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcgcctctgccccgacggcTtctacggtctcagctgccag	5	9	10	17	4	3	0	1	0	3	0	5	1	3	0	4	2	4	2	4	2	1	2			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr1:156878077T>A	uc001fqj.1	+	9	1176	c.1060T>A	c.(1060-1062)TTC>ATC	p.F354I	PEAR1_uc009wsl.1_Missense_Mutation_p.F155I|PEAR1_uc001fqk.1_5'UTR	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	354						integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCCCGACGGCTTCTACGGTCT	0.692													6	8					0	0	0	0	A	156878077	A	A	156878077	3	1	290	1	0	0	0	0	1	0	0	0	11766	1609	56	5	1090	5	PEAR1	1	156878077	Missense_Mutation	SNP	T	TCGA-DQ-7590-01A-11D-2229-08	4144354	156878077	92372544	6	53789											
RASAL2	9462	broad.mit.edu	37	chr1	178412244	178412245	+	Frame_Shift_Ins	INS	-	T	T																															aatacaaagaatttgcagaaINStttgtcaccagcaactacac																										TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr1:178412244_178412245insT	uc001glr.2	+	6	1043_1044	c.918_919insT	c.(916-921)GAATTTfs	p.E306fs	RASAL2_uc001glq.2_Frame_Shift_Ins_p.E454fs	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	306_307					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						AATTTGCAGAATTTGTCACCAG	0.421													---	---	---								T	178412245	T	T	178412244	7	5	290	1	0	1	1	0	0	0	0	0	13129	98	4	0	1409	0	RASAL2	1	178412244	Frame_Shift_Ins	INS	-	TCGA-DQ-7590-01A-11D-2229-08	21534167	178412244	70838377	7	53790											
HMCN1	83872	broad.mit.edu	37	chr1	186113447	186113447	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatggagcagaaacacagatGcaagtttgcaatgaaagaaa	19	6	11	5	0	0	4	0	1	0	3	0	6	0	5	0	1	4	4	0	1	5	1			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr1:186113447G>A	uc001grq.1	+	90	14296	c.14067G>A	c.(14065-14067)ATG>ATA	p.M4689I	HMCN1_uc001grs.1_Missense_Mutation_p.M258I	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4689	TSP type-1 3.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AAACACAGATGCAAGTTTGCA	0.388													34	132					0	0	0	0	A	186113447	A	A	186113447	3	1	290	1	0	0	0	0	1	0	0	0	7259	1319	46	4	14425	4	HMCN1	1	186113447	Missense_Mutation	SNP	G	TCGA-DQ-7590-01A-11D-2229-08	7701203	186113447	63137174	8	53791											
NLRP3	114548	broad.mit.edu	37	chr1	247597557	247597557	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggactgaagcacctgttgtGcaatctgaagaagctctggt	10	10	13	8	0	2	3	0	2	2	1	2	4	2	4	1	2	3	4	1	2	4	1			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr1:247597557G>A	uc001icr.2	+	7	2618	c.2480G>A	c.(2479-2481)TGC>TAC	p.C827Y	NLRP3_uc001ics.2_Missense_Mutation_p.C827Y|NLRP3_uc001icu.2_Missense_Mutation_p.C827Y|NLRP3_uc001icw.2_Missense_Mutation_p.C770Y|NLRP3_uc001icv.2_Missense_Mutation_p.C770Y|NLRP3_uc010pyw.1_Missense_Mutation_p.C805Y	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	827					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CACCTGTTGTGCAATCTGAAG	0.592													21	71					0	0	0	0	A	247597557	A	A	247597557	3	1	290	1	0	0	0	0	1	0	0	0	10532	1319	46	4	2498	4	NLRP3	1	247597557	Missense_Mutation	SNP	G	TCGA-DQ-7590-01A-11D-2229-08	61484110	247597557	1653064	9	53792											
SYNCRIP	10492	broad.mit.edu	37	chr6	86333749	86333749	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttggttttactcttaggaaTagagcccacaaaaagcctat	13	12	7	9	0	1	1	0	0	1	1	1	2	1	2	2	2	3	1	2	2	7	6			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr6:86333749T>A	uc003pla.2	-	7	1289	c.748A>T	c.(748-750)ATT>TTT	p.I250F	SYNCRIP_uc003pku.2_Missense_Mutation_p.I250F|SYNCRIP_uc003pkw.2_Missense_Mutation_p.I250F|SYNCRIP_uc003pky.2_Missense_Mutation_p.I152F|SYNCRIP_uc003pkv.2_Missense_Mutation_p.I250F|SYNCRIP_uc003pkx.2_Missense_Mutation_p.I98F|SYNCRIP_uc003pkz.2_Missense_Mutation_p.I250F	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	250	RRM 2.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		CTCTTAGGAATAGAGCCCACA	0.348													12	27					0	0	0	0	A	86333749	A	A	86333749	3	1	290	1	0	0	0	0	1	0	0	0	15510	1406	49	5	1189	5	SYNCRIP	6	86333749	Missense_Mutation	SNP	T	TCGA-DQ-7590-01A-11D-2229-08		86333749	84781318	10	53793											
RARS2	57038	broad.mit.edu	37	chr6	88227948	88227948	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taaacaagcagtgttgaagtCattcaggtacccacatccaa	15	9	7	10	0	2	1	2	1	0	0	3	1	3	1	2	1	3	3	2	1	6	4			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr6:88227948C>A	uc003pme.2	-	17	1510	c.1450G>T	c.(1450-1452)GAC>TAC	p.D484Y	RARS2_uc003pmb.2_Missense_Mutation_p.D309Y|RARS2_uc003pmc.2_Missense_Mutation_p.D309Y|RARS2_uc003pmd.2_Missense_Mutation_p.D121Y|RARS2_uc003pmf.2_RNA	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	484					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		GTGTTGAAGTCATTCAGGTAC	0.383													23	70					9.86323e-18	1.10961e-17	1	0	A	88227948	A	A	88227948	3	1	290	1	0	0	0	0	1	0	0	0	13124	826	29	2	302	2	RARS2	6	88227948	Missense_Mutation	SNP	C	TCGA-DQ-7590-01A-11D-2229-08	1894199	88227948	82887119	11	53794											
TMEM184A	202915	broad.mit.edu	37	chr7	1588285	1588285	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agggcgaggctgacggaggcGttgtagatgagggtcacata	10	7	18	6	3	1	3	1	2	0	1	1	5	1	4	0	5	0	3	0	5	2	3			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr7:1588285G>A	uc003skv.3	-	7	1001	c.684C>T	c.(682-684)AAC>AAT	p.N228N	TMEM184A_uc003skt.3_Silent_p.N207N|TMEM184A_uc003skw.3_Silent_p.N33N	NM_001097620	NP_001091089	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	228	Helical; (Potential).					integral to membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		TGACGGAGGCGTTGTAGATGA	0.632													17	46					0	0	0	0	A	1588285	A	A	1588285	2	1	290	1	0	0	0	0	0	0	0	1	16170	1136	40	1		1	TMEM184A	7	1588285	Silent	SNP	G	TCGA-DQ-7590-01A-11D-2229-08		1588285	157550378	12	53795											
ELP3	55140	broad.mit.edu	37	chr8	28017757	28017757	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actaaataggttgaattggtAaggagagattatgttgcaaa	16	12	11	2	0	0	2	0	1	0	1	0	4	0	3	0	3	1	4	0	3	7	7			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr8:28017757A>T	uc003xgo.3	+	13	1417	c.1269A>T	c.(1267-1269)GTA>GTT	p.V423V	ELP3_uc003xgn.3_Silent_p.V408V|ELP3_uc011laq.1_Silent_p.V351V|ELP3_uc011lar.1_Silent_p.V331V|ELP3_uc011las.1_Silent_p.V304V|ELP3_uc011lat.1_Silent_p.V304V	NM_018091	NP_060561	Q9H9T3	ELP3_HUMAN	elongation protein 3 homolog	423	N-acetyltransferase.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding				0		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		TTGAATTGGTAAGGAGAGATT	0.313													10	36					0	0	0	0	T	28017757	T	T	28017757	2	4	290	1	0	0	0	0	0	0	0	1	5105	349	13	5		5	ELP3	8	28017757	Silent	SNP	A	TCGA-DQ-7590-01A-11D-2229-08		28017757	118346265	13	53796											
TRHR	7201	broad.mit.edu	37	chr8	110099808	110099808	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacgagcagtggtggccttaGaataccaggtggtcaccatc	10	8	12	11	1	1	1	1	0	0	1	2	2	1	1	3	4	2	1	3	4	3	2			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr8:110099808G>T	uc003ymz.3	+	1	83	c.67G>T	c.(67-69)GAA>TAA	p.E23*		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	23	Extracellular (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GGTGGCCTTAGAATACCAGGT	0.458													12	36					7.93312e-07	8.15978e-07	1	0	T	110099808	T	T	110099808	4	4	290	1	0	0	0	0	0	1	0	0	16547	943	33	2	69	2	TRHR	8	110099808	Nonsense_Mutation	SNP	G	TCGA-DQ-7590-01A-11D-2229-08	82082051	110099808	36264214	14	53797											
DFNB31	25861	broad.mit.edu	37	chr9	117266568	117266568	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcagctagagagcctggttCcaccagagacacgtagatgc	11	7	11	12	1	1	3	1	0	0	3	2	5	2	3	3	1	3	3	3	1	2	3			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr9:117266568C>T	uc004biz.3	-	1	1163	c.514G>A	c.(514-516)GAA>AAA	p.E172K	DFNB31_uc004biy.3_5'Flank|DFNB31_uc004bja.3_Missense_Mutation_p.E172K|DFNB31_uc004bjb.2_Missense_Mutation_p.E172K	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	172	PDZ 1.				inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						GAGCCTGGTTCCACCAGAGAC	0.662													28	100					0	0	0	0	T	117266568	T	T	117266568	3	4	290	1	0	0	0	0	1	0	0	0	4477	864	30	2	2257	2	DFNB31	9	117266568	Missense_Mutation	SNP	C	TCGA-DQ-7590-01A-11D-2229-08		117266568	23946863	15	53798											
DPP7	29952	broad.mit.edu	37	chr9	140006472	140006472	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcgaaggtcaggttgatctCggtgcaggcctgcaggtgcc	6	8	17	10	2	2	1	1	1	1	0	3	2	2	1	2	6	3	3	2	6	1	1			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr9:140006472C>T	uc004clh.2	-	10	1090	c.1060G>A	c.(1060-1062)GAG>AAG	p.E354K		NM_013379	NP_037511	Q9UHL4	DPP2_HUMAN	dipeptidyl peptidase 7 preproprotein	354						cytoplasmic membrane-bounded vesicle|extracellular region|lysosome	aminopeptidase activity|protein binding|serine-type peptidase activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;4.25e-05)|Epithelial(140;0.000633)		AGGTTGATCTCGGTGCAGGCC	0.657													14	55					0	0	0	0	T	140006472	T	T	140006472	3	4	290	1	0	0	0	0	1	0	0	0	4753	893	31	1	434	1	DPP7	9	140006472	Missense_Mutation	SNP	C	TCGA-DQ-7590-01A-11D-2229-08	22739904	140006472	1206959	16	53799											
FOLH1	2346	broad.mit.edu	37	chr11	49168484	49168484	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttgttgtggctgcttggagCatagatgacatgcctgttga	7	14	13	7	0	0	3	0	2	0	1	0	4	0	4	1	2	3	5	1	2	1	5			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr11:49168484C>T	uc001ngy.2	-	19	2338	c.2077G>A	c.(2077-2079)GCT>ACT	p.A693T	FOLH1_uc001ngx.2_Missense_Mutation_p.M92I|FOLH1_uc001ngz.2_Missense_Mutation_p.A662T|FOLH1_uc009yly.2_Missense_Mutation_p.A678T|FOLH1_uc009ylz.2_Missense_Mutation_p.A647T|FOLH1_uc009yma.2_Missense_Mutation_p.A385T	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	693	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	CTGCTTGGAGCATAGATGACA	0.438													22	81					0	0	0	0	T	49168484	T	T	49168484	3	4	290	1	0	0	0	0	1	0	0	0	6011	710	25	4	179	4	FOLH1	11	49168484	Missense_Mutation	SNP	C	TCGA-DQ-7590-01A-11D-2229-08		49168484	85838032	17	53800											
ARRB1	408	broad.mit.edu	37	chr11	74987886	74987886	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacttgtgcccacttactcaGcctcttccatggcaacaggg	8	10	9	14	0	2	0	1	0	1	0	3	1	3	0	3	2	4	1	3	2	2	3			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr11:74987886G>T	uc001owe.1	-	10	995	c.773C>A	c.(772-774)GCT>GAT	p.A258D	ARRB1_uc001owf.1_Missense_Mutation_p.A258D	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	258					G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						CACTTACTCAGCCTCTTCCAT	0.537													11	23					5.16669e-11	5.47061e-11	1	0	T	74987886	T	T	74987886	3	4	290	1	0	0	0	0	1	0	0	0	982	971	34	4	511	4	ARRB1	11	74987886	Missense_Mutation	SNP	G	TCGA-DQ-7590-01A-11D-2229-08	25819402	74987886	60018630	18	53801											
C11orf53	341032	broad.mit.edu	37	chr11	111156492	111156492	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcctctcccagcttgagtccGggagcatcgcccagcacagg	7	6	12	16	2	1	1	0	1	1	0	4	2	2	2	4	2	3	3	4	2	0	1			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr11:111156492G>C	uc001plc.2	+	4	571	c.424G>C	c.(424-426)GGG>CGG	p.G142R		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	142											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		GCTTGAGTCCGGGAGCATCGC	0.642													21	61					0	0	0	0	C	111156492	C	C	111156492	3	2	290	1	0	0	0	0	1	0	0	0	1654	1116	39	3	434	3	C11orf53	11	111156492	Missense_Mutation	SNP	G	TCGA-DQ-7590-01A-11D-2229-08	36168606	111156492	23850024	19	53802											
TMCC3	57458	broad.mit.edu	37	chr12	94972193	94972193	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatgtcccgcgagcgctcgtAggcctggtaggccaccttct	5	9	13	14	4	1	0	0	0	1	0	3	2	2	0	4	3	1	3	4	3	2	3			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr12:94972193A>G	uc001tdj.2	-	3	1226	c.1108T>C	c.(1108-1110)TAC>CAC	p.Y370H	TMCC3_uc001tdi.2_Missense_Mutation_p.Y339H	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	370	Potential.					integral to membrane				ovary(1)|skin(1)	2						GAGCGCTCGTAGGCCTGGTAG	0.542													20	60					0	0	0	0	G	94972193	G	G	94972193	3	3	290	1	0	0	0	0	1	0	0	0	16060	420	15	5	333	5	TMCC3	12	94972193	Missense_Mutation	SNP	A	TCGA-DQ-7590-01A-11D-2229-08		94972193	38879702	20	53803											
FAM101A	144347	broad.mit.edu	37	chr12	124798924	124798926	+	In_Frame_Del	DEL	CAT	-	-																															ctgcgcttccgcagcaccacCatcatcttccccaagcatgc																										TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr12:124798924_124798926delCAT	uc001ugd.1	+	3	504_506	c.261_263delCAT	c.(259-264)ACCATC>ACC	p.I89del	FAM101A_uc001uge.1_In_Frame_Del_p.I89del	NM_181709	NP_859060	Q6ZTI6	F101A_HUMAN	hypothetical protein LOC144347	170											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		GCAGCACCACCATCATCTTCCCC	0.685													---	---	---								-	124798926	-	-	124798924	7	5	290	1	0	1	0	1	0	0	0	0	5408	581	21	0	267	0	FAM101A	12	124798924	In_Frame_Del	DEL	CAT	TCGA-DQ-7590-01A-11D-2229-08	29826731	124798924	9052971	21	53804											
CETP	1071	broad.mit.edu	37	chr16	57007305	57007305	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cccaccttctcgcccacactGctgggggactcccgcatgct	5	8	9	19	2	1	0	0	0	1	0	3	1	2	1	4	2	2	3	4	2	0	1			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr16:57007305G>A	uc002eki.2	+	9	870	c.813G>A	c.(811-813)CTG>CTA	p.L271L	CETP_uc002ekj.2_Intron	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	271					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						CGCCCACACTGCTGGGGGACT	0.597													24	61					0	0	0	0	A	57007305	A	A	57007305	2	1	290	1	0	0	0	0	0	0	0	1	3292	1306	46	4		4	CETP	16	57007305	Silent	SNP	G	TCGA-DQ-7590-01A-11D-2229-08		57007305	33347448	22	53805											
RHBDF2	79651	broad.mit.edu	37	chr17	74467882	74467882	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgacaccaggatgagtgcccGcttgcggtacttgtcgctgg	6	10	14	11	3	0	2	0	2	0	0	1	3	0	3	2	3	3	3	2	3	1	3			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr17:74467882G>A	uc002jrq.1	-	19	2697	c.2404C>T	c.(2404-2406)CGG>TGG	p.R802W	RHBDF2_uc002jrp.1_Missense_Mutation_p.R773W|RHBDF2_uc002jrr.1_3'UTR	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	802	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						ATGAGTGCCCGCTTGCGGTAC	0.617													5	11					0	0	0	0	A	74467882	A	A	74467882	3	1	290	1	0	0	0	0	1	0	0	0	13385	1086	38	1	170	1	RHBDF2	17	74467882	Missense_Mutation	SNP	G	TCGA-DQ-7590-01A-11D-2229-08		74467882	6727328	23	53806											
ARHGEF1	9138	broad.mit.edu	37	chr19	42409386	42409386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtccctgcccctgcctctcGccctaagccccggcccagcc	4	6	8	23	2	1	0	0	0	1	0	3	0	2	0	9	1	4	0	9	1	1	1			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr19:42409386G>A	uc002orx.2	+	24	2418	c.2309G>A	c.(2308-2310)CGC>CAC	p.R770H	ARHGEF1_uc002ory.2_Missense_Mutation_p.R737H|ARHGEF1_uc002orz.2_Missense_Mutation_p.R608H|ARHGEF1_uc002osa.2_Missense_Mutation_p.R785H|ARHGEF1_uc002osb.2_Missense_Mutation_p.R752H|ARHGEF1_uc002osc.2_Missense_Mutation_p.R524H|ARHGEF1_uc002osd.2_Missense_Mutation_p.R429H|ARHGEF1_uc002ose.2_Missense_Mutation_p.R214H	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	770					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		CCTGCCTCTCGCCCTAAGCCC	0.667													26	77					0	0	0	0	A	42409386	A	A	42409386	3	1	290	1	0	0	0	0	1	0	0	0	893	1087	38	1	2448	1	ARHGEF1	19	42409386	Missense_Mutation	SNP	G	TCGA-DQ-7590-01A-11D-2229-08		42409386	16719597	24	53807											
CD177	57126	broad.mit.edu	37	chr19	43858524	43858524	+	Frame_Shift_Del	DEL	G	-	-																															cgttaactccctcccgctttGggccccacagcccccagcag																										TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr19:43858524delG	uc002owi.2	+	3	401	c.359delG	c.(358-360)TGGfs	p.W120fs	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	120					blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				CTCCCGCTTTGGGCCCCACAG	0.652													---	---	---								-	43858524	-	-	43858524	7	5	290	1	0	1	0	1	0	0	0	0	2986	1357	47	0	369	0	CD177	19	43858524	Frame_Shift_Del	DEL	G	TCGA-DQ-7590-01A-11D-2229-08	1449138	43858524	15270459	25	53808											
ZNF285	26974	broad.mit.edu	37	chr19	44891069	44891069	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcccctgtgtggactctctgGtgaatgtgaaggtgtgtaca	7	13	13	8	0	1	2	0	2	1	0	3	3	2	3	2	3	1	1	2	3	3	1			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr19:44891069G>C	uc002ozd.3	-	4	1425	c.1338C>G	c.(1336-1338)CAC>CAG	p.H446Q	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.H453Q	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	446	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						GGACTCTCTGGTGAATGTGAA	0.473													14	51					0	0	0	0	C	44891069	C	C	44891069	3	2	290	1	0	0	0	0	1	0	0	0	17889	1252	44	4	438	4	ZNF285	19	44891069	Missense_Mutation	SNP	G	TCGA-DQ-7590-01A-11D-2229-08	1032545	44891069	14237914	26	53809											
BCL3	602	broad.mit.edu	37	chr19	45262784	45262784	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caatttcttccttccttcccCatctccacccgccttcctgc	4	14	2	21	1	2	0	0	0	2	0	7	0	6	0	8	0	1	0	8	0	1	5			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr19:45262784C>T	uc010xxe.1	+	9	1347	c.1277C>T	c.(1276-1278)CCA>CTA	p.P426L		NM_005178	NP_005169	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	426	Pro/Ser-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			ovary(1)|lung(1)	2	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CTTCCTTCCCCATCTCCACCC	0.682			T	IGH@	CLL 								89	331					0	0	0	0	T	45262784	T	T	45262784	3	4	290	1	0	0	0	0	1	0	0	0	1377	594	21	4	1311	4	BCL3	19	45262784	Missense_Mutation	SNP	C	TCGA-DQ-7590-01A-11D-2229-08	371715	45262784	13866199	27	53810											
RPL18	6141	broad.mit.edu	37	chr19	49118662	49118663	+	Frame_Shift_Ins	INS	-	AA	AA																															ctcggctggcccgtcggcctINSctggcacgctcgaacttccg																										TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr19:49118662_49118663insAA	uc002pjq.1	-	7	566_567	c.533_534insTT	c.(532-534)AGAfs	p.R178fs	FAM83E_uc002pjn.2_5'Flank|RPL18_uc002pjp.1_Frame_Shift_Ins_p.R126fs	NM_000979	NP_000970	Q07020	RL18_HUMAN	ribosomal protein L18	178					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.89e-05)|all cancers(93;0.00011)|GBM - Glioblastoma multiforme(486;0.0061)|Epithelial(262;0.0154)		CCCGTCGGCCTCTGGCACGCTC	0.559													---	---	---								AA	49118663	AA	AA	49118662	7	5	290	1	0	1	1	0	0	0	0	0	13629	1548	54	0	36	0	RPL18	19	49118662	Frame_Shift_Ins	INS	-	TCGA-DQ-7590-01A-11D-2229-08	3855878	49118662	10010321	28	53811											
IFNAR1	3454	broad.mit.edu	37	chr21	34725168	34725168	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accatggatgaaaagctgaaTaaaagcagtgtttttagtga	16	11	10	4	0	0	3	0	3	0	0	0	4	0	4	1	1	2	3	1	1	6	4			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr21:34725168T>A	uc002yrn.2	+	9	1395	c.1248T>A	c.(1246-1248)AAT>AAA	p.N416K	IFNAR1_uc011adv.1_Missense_Mutation_p.N347K	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	416	Fibronectin type-III 3.|Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	AAAAGCTGAATAAAAGCAGTG	0.323													15	50					0	0	0	0	A	34725168	A	A	34725168	3	1	290	1	0	0	0	0	1	0	0	0	7583	1403	49	5	1282	5	IFNAR1	21	34725168	Missense_Mutation	SNP	T	TCGA-DQ-7590-01A-11D-2229-08		34725168	13404727	29	53812											
SAPS2	9701	broad.mit.edu	37	chr22	50854550	50854550	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaagagaaggtcatccagagGcttgtggagttgatccaccc	11	8	13	9	0	1	3	1	1	0	2	3	6	3	4	3	3	0	2	3	3	2	2			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chr22:50854550G>A	uc003blb.1	+	7	1004	c.582G>A	c.(580-582)AGG>AGA	p.R194R	SAPS2_uc003bky.1_Silent_p.R194R|SAPS2_uc003bkz.1_Silent_p.R194R|SAPS2_uc003blc.2_Silent_p.R194R|SAPS2_uc003bla.1_Silent_p.R194R	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	194						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		TCATCCAGAGGCTTGTGGAGT	0.517													19	64					0	0	0	0	A	50854550	A	A	50854550	2	1	290	1	0	0	0	0	0	0	0	1	13902	1194	42	4		4	SAPS2	22	50854550	Silent	SNP	G	TCGA-DQ-7590-01A-11D-2229-08		50854550	450016	30	53813											
NLGN4X	57502	broad.mit.edu	37	chrX	5811300	5811300	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacttaattcggtggaataaTctcgtttggtttcaatgagg	10	15	10	6	2	2	1	1	1	1	0	4	2	2	2	0	4	0	2	0	4	4	5			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chrX:5811300T>A	uc010ndh.2	-	6	2510	c.2009A>T	c.(2008-2010)GAT>GTT	p.D670V	NLGN4X_uc004crp.2_Missense_Mutation_p.D690V|NLGN4X_uc004crq.2_Missense_Mutation_p.D670V|NLGN4X_uc010ndi.2_Missense_Mutation_p.D707V|NLGN4X_uc004crr.2_Missense_Mutation_p.D670V|NLGN4X_uc010ndj.2_Missense_Mutation_p.D670V	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	670	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GGTGGAATAATCTCGTTTGGT	0.498													30	43					0	0	0	0	A	5811300	A	A	5811300	3	1	290	1	0	0	0	0	1	0	0	0	10518	1435	50	5	445	5	NLGN4X	23	5811300	Missense_Mutation	SNP	T	TCGA-DQ-7590-01A-11D-2229-08		5811300	149459260	31	53814											
ITIH5L	347365	broad.mit.edu	37	chrX	54824635	54824635	+	Frame_Shift_Del	DEL	C	-	-																															acacagatgaggtacctccaCccagacatgatgccacctct																										TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chrX:54824635delC	uc004dtj.2	-	1	39	c.9delG	c.(7-9)GGGfs	p.G3fs		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	3					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GGTACCTCCACCCAGACATGA	0.507													---	---	---								-	54824635	-	-	54824635	7	5	290	1	0	1	0	1	0	0	0	0	7947	494	18	0	3984	0	ITIH5L	23	54824635	Frame_Shift_Del	DEL	C	TCGA-DQ-7590-01A-11D-2229-08	49013335	54824635	100445925	32	53815											
NXF3	56000	broad.mit.edu	37	chrX	102333543	102333543	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ggtgaaggcgagaacagaacCctgagactgtccttccactt	11	8	11	11	1	0	4	0	2	0	3	2	6	2	4	3	2	2	0	3	2	3	2			TCGA-DQ-7590-01A-11D-2229-08	TCGA-DQ-7590-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	5cbcfa67-f062-4a03-84ad-dabfbcf14514	1165b9b5-0a5a-44e2-8bff-74e98cdb9d99	g.chrX:102333543C>A	uc004eju.2	-	17	1467	c.1396G>T	c.(1396-1398)GGT>TGT	p.G466C	NXF3_uc010noi.1_Missense_Mutation_p.G312V	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	466	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						AGAACAGAACCCTGAGACTGT	0.532													34	119					4.25531e-23	4.94166e-23	1	0	A	102333543	A	A	102333543	3	1	290	1	0	0	0	0	1	0	0	0	10839	623	22	4	211	4	NXF3	23	102333543	Missense_Mutation	SNP	C	TCGA-DQ-7590-01A-11D-2229-08	47508908	102333543	52937017	33	53816											
COL11A1	1301	broad.mit.edu	37	chr1	103405905	103405905	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtctccgtcttccccagggGagccggcaggaccagctggc	5	7	14	15	2	2	0	0	0	2	0	4	2	3	2	5	5	2	2	5	5	0	1			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr1:103405905G>C	uc001dul.2	-	43	3680	c.3362C>G	c.(3361-3363)TCC>TGC	p.S1121C	COL11A1_uc001duk.2_Missense_Mutation_p.S317C|COL11A1_uc001dum.2_Missense_Mutation_p.S1133C|COL11A1_uc001dun.2_Missense_Mutation_p.S1082C|COL11A1_uc009weh.2_Missense_Mutation_p.S1005C	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1121	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTCCCCAGGGGAGCCGGCAGG	0.473													17	33					0	0	0	0	C	103405905	C	C	103405905	3	2	291	1	0	0	0	0	1	0	0	0	3682	1174	41	2	2158	2	COL11A1	1	103405905	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08		103405905	145844716	1	53817											
TMOD4	29765	broad.mit.edu	37	chr1	151143016	151143016	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagttcattgtttcgggtcaTggcctgggctgcccgagctc	4	13	13	11	2	2	0	2	0	0	0	4	1	2	0	2	3	2	4	2	3	1	4	rs143662204	byFrequency	TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr1:151143016T>C	uc001exc.3	-	9	1184	c.994A>G	c.(994-996)ATG>GTG	p.M332V	TMOD4_uc001exb.2_Missense_Mutation_p.M160V|TMOD4_uc001exd.2_RNA|TMOD4_uc010pct.1_Missense_Mutation_p.M263V	NM_013353	NP_037485	Q9NZQ9	TMOD4_HUMAN	tropomodulin 4 (muscle)	332					muscle contraction	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTTCGGGTCATGGCCTGGGCT	0.542													6	123					0	0	0	0	C	151143016	C	C	151143016	3	2	291	1	0	0	0	0	1	0	0	0	16302	1464	51	5	51	5	TMOD4	1	151143016	Missense_Mutation	SNP	T	TCGA-DQ-7591-01A-11D-2078-08	47737111	151143016	98107605	2	53818											
OLFML2B	25903	broad.mit.edu	37	chr1	161954641	161954641	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actctaccagggtgttgccgTagtaatagttggttacgtaa	10	13	11	7	2	1	0	0	0	1	0	1	0	1	0	2	2	3	6	2	2	6	8			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr1:161954641T>C	uc001gbu.2	-	7	2028	c.1604A>G	c.(1603-1605)TAC>TGC	p.Y535C	OLFML2B_uc001gbt.2_Missense_Mutation_p.Y18C|OLFML2B_uc010pkq.1_Missense_Mutation_p.Y536C	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	535	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGTGTTGCCGTAGTAATAGTT	0.542													42	79					0	0	0	0	C	161954641	C	C	161954641	3	2	291	1	0	0	0	0	1	0	0	0	10912	1638	57	5	656	5	OLFML2B	1	161954641	Missense_Mutation	SNP	T	TCGA-DQ-7591-01A-11D-2078-08	10811625	161954641	87295980	3	53819											
ALK	238	broad.mit.edu	37	chr2	29455179	29455179	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcgctttacctgcggctcCggaattgccgtttagcccta	6	11	10	14	4	0	0	0	0	0	0	1	1	1	1	4	2	5	3	4	2	4	6	rs148001139		TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr2:29455179C>T	uc002rmy.2	-	15	3530	c.2623G>A	c.(2623-2625)GGA>AGA	p.G875R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	875	Gly-rich.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCTGCGGCTCCGGAATTGCCG	0.617			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				6	91					0	0	0	0	T	29455179	T	T	29455179	3	4	291	1	0	0	0	0	1	0	0	0	525	661	23	1	2299	1	ALK	2	29455179	Missense_Mutation	SNP	C	TCGA-DQ-7591-01A-11D-2078-08		29455179	213744194	4	53820											
SCN1A	6323	broad.mit.edu	37	chr2	166848284	166848284	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gattgagaggcggttcaagcGcagctgcaaactgagataat	13	8	13	7	2	1	2	1	2	0	2	1	5	1	2	0	2	4	4	0	2	3	3			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr2:166848284G>A	uc010zcz.1	-	26	5486	c.5468C>T	c.(5467-5469)GCG>GTG	p.A1823V		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1834						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CGGTTCAAGCGCAGCTGCAAA	0.458													43	64					0	0	0	0	A	166848284	A	A	166848284	3	1	291	1	0	0	0	0	1	0	0	0	13979	1087	38	1	532	1	SCN1A	2	166848284	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08	137393105	166848284	76351089	5	53821											
CDK15	65061	broad.mit.edu	37	chr2	202700438	202700438	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccctctggtaccggccccCtgatgctttgctgggagcca	5	9	12	15	1	1	1	0	1	1	0	1	3	1	2	5	3	4	3	5	3	1	2			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr2:202700438C>T	uc002uyt.2	+	8	852	c.803C>T	c.(802-804)CCT>CTT	p.P268L	CDK15_uc010ftm.2_Missense_Mutation_p.P133L|CDK15_uc002uys.2_Missense_Mutation_p.P217L|CDK15_uc010ftn.1_Missense_Mutation_p.P217L|CDK15_uc010fto.1_Missense_Mutation_p.P247L	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	268	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	TACCGGCCCCCTGATGCTTTG	0.522													15	29					0	0	0	0	T	202700438	T	T	202700438	3	4	291	1	0	0	0	0	1	0	0	0	3146	681	24	4	676	4	CDK15	2	202700438	Missense_Mutation	SNP	C	TCGA-DQ-7591-01A-11D-2078-08	35852154	202700438	40498935	6	53822											
MAP2	4133	broad.mit.edu	37	chr2	210594941	210594941	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttgaacttcagagagcatgcTaaagcccgtgtggaccatgg	11	9	12	9	1	1	2	1	1	0	1	1	4	1	3	2	2	4	2	2	2	3	3			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr2:210594941T>A	uc002vde.1	+	15	5552	c.5304T>A	c.(5302-5304)GCT>GCA	p.A1768A	MAP2_uc002vdd.1_Silent_p.A500A|MAP2_uc002vdf.1_Silent_p.A443A|MAP2_uc002vdg.1_Silent_p.A412A|MAP2_uc002vdh.1_Silent_p.A469A|MAP2_uc002vdi.1_Silent_p.A1764A	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1768					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GAGAGCATGCTAAAGCCCGTG	0.512													9	17					0	0	0	0	A	210594941	A	A	210594941	2	1	291	1	0	0	0	0	0	0	0	1	9288	1509	53	5		5	MAP2	2	210594941	Silent	SNP	T	TCGA-DQ-7591-01A-11D-2078-08	7894503	210594941	32604432	7	53823											
COL4A4	1286	broad.mit.edu	37	chr2	228009238	228009238	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgaatgtacttaccccataTacatattgtacagaaaagag	16	11	7	7	0	0	3	0	1	0	2	0	3	0	3	2	0	4	2	2	0	9	7			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr2:228009238T>A	uc010zlt.1	-	3	762	c.108A>T	c.(106-108)GTA>GTT	p.V36V		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	36					axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTACCCCATATACATATTGTA	0.269													19	45					0	0	0	0	A	228009238	A	A	228009238	2	1	291	1	0	0	0	0	0	0	0	1	3708	1393	49	5		5	COL4A4	2	228009238	Silent	SNP	T	TCGA-DQ-7591-01A-11D-2078-08	17414297	228009238	15190135	8	53824											
SENP2	59343	broad.mit.edu	37	chr3	185316239	185316239	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gaaaaacagtctctacaatgCtgccagcttatttggattcc	12	12	7	10	0	1	0	0	0	1	0	3	2	2	1	2	1	5	2	2	1	5	4			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr3:185316239C>T	uc003fpn.2	+	3	368	c.197C>T	c.(196-198)GCT>GTT	p.A66V	SENP2_uc011brv.1_Missense_Mutation_p.A56V|SENP2_uc011brw.1_5'UTR	NM_021627	NP_067640	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific protease 2	66					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity				0	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			CTCTACAATGCTGCCAGCTTA	0.393													11	36					0	0	0	0	T	185316239	T	T	185316239	3	4	291	1	0	0	0	0	1	0	0	0	14112	797	28	4	207	4	SENP2	3	185316239	Missense_Mutation	SNP	C	TCGA-DQ-7591-01A-11D-2078-08		185316239	12706191	9	53825											
SLIT2	9353	broad.mit.edu	37	chr4	20597445	20597445	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cggctatacgtgcatatgccCcgaaggttacaggtaaaagc	12	8	11	10	3	0	0	0	0	0	0	0	1	0	0	2	3	5	4	2	3	7	5			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr4:20597445C>T	uc003gpr.1	+	31	3512	c.3308C>T	c.(3307-3309)CCC>CTC	p.P1103L	SLIT2_uc003gps.1_Missense_Mutation_p.P1095L	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1103	EGF-like 5; calcium-binding (Potential).				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TGCATATGCCCCGAAGGTTAC	0.303													19	36					0	0	0	0	T	20597445	T	T	20597445	3	4	291	1	0	0	0	0	1	0	0	0	14804	623	22	4	3430	4	SLIT2	4	20597445	Missense_Mutation	SNP	C	TCGA-DQ-7591-01A-11D-2078-08		20597445	170556831	10	53826											
CHD1	1105	broad.mit.edu	37	chr5	98233988	98233988	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttaaaaggagtggtttttGattggttcctgctaaaatac	11	16	9	5	0	0	1	0	1	0	0	1	2	1	2	1	3	2	3	1	3	5	8			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr5:98233988G>T	uc003knf.2	-	9	1485	c.1337C>A	c.(1336-1338)TCA>TAA	p.S446*		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	446	Chromo 2.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	AGTGGTTTTTGATTGGTTCCT	0.323													9	31					0.000442599	0.000467188	1	0	T	98233988	T	T	98233988	4	4	291	1	0	0	0	0	0	1	0	0	3338	1294	45	2	3903	2	CHD1	5	98233988	Nonsense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08		98233988	82681272	11	53827											
PCDHA11	56138	broad.mit.edu	37	chr5	140250616	140250616	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacgaggcagactcgccgcGccaccgacttctagtactgg	8	6	13	14	5	1	1	0	0	1	1	2	4	1	2	3	3	1	2	3	3	2	3			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr5:140250616G>A	uc003lia.2	+	1	2786	c.1928G>A	c.(1927-1929)CGC>CAC	p.R643H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R643H	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	643	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACTCGCCGCGCCACCGACTT	0.687													20	41					0	0	0	0	A	140250616	A	A	140250616	3	1	291	1	0	0	0	0	1	0	0	0	11575	1087	38	1	1930	1	PCDHA11	5	140250616	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08	42016628	140250616	40664644	12	53828											
FAT2	2196	broad.mit.edu	37	chr5	150922619	150922619	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tatacaaaggttcagaaaatTtcggtaaggatactttttta	15	15	7	4	1	1	1	1	0	0	1	2	2	1	2	0	3	2	2	0	3	8	9			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr5:150922619T>C	uc003lue.3	-	9	8082	c.8069A>G	c.(8068-8070)AAA>AGA	p.K2690R	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2690	Cadherin 23.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAGAAAATTTCGGTAAGGA	0.463													26	40					0	0	0	0	C	150922619	C	C	150922619	3	2	291	1	0	0	0	0	1	0	0	0	5722	1841	64	5	5040	5	FAT2	5	150922619	Missense_Mutation	SNP	T	TCGA-DQ-7591-01A-11D-2078-08	10672003	150922619	29992641	13	53829											
POLB	5423	broad.mit.edu	37	chr8	42196204	42196204	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aatcaccgacatgctcacagGttagcaccgggccgggcccc	9	5	11	16	3	2	0	2	0	0	0	2	1	2	0	5	3	2	3	5	3	2	1			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr8:42196204G>T	uc003xoz.1	+	1	174	c.61_splice	c.e1+1	p.E21_splice	POLB_uc003xpa.1_Splice_Site_p.E21_splice|POLB_uc011lcs.1_Splice_Site	NM_002690	NP_002681	P06746	DPOLB_HUMAN	DNA-directed DNA polymerase beta						DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			ovary(1)|breast(1)	2	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)	ATGCTCACAGGTTAGCACCGG	0.617								DNA_polymerases_(catalytic_subunits)					31	56					1.16021e-09	1.24777e-09	1	0	T	42196204	T	T	42196204	5	4	291	1	0	0	0	0	0	0	1	0	12244	1275	44	4	64	4	POLB	8	42196204	Splice_Site	SNP	G	TCGA-DQ-7591-01A-11D-2078-08		42196204	104167818	14	53830											
GPAA1	8733	broad.mit.edu	37	chr8	145139221	145139221	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaagggggcctgttgtgcacGcttcagggcaaggtggggct	7	8	18	8	1	1	0	1	0	0	0	1	0	1	0	1	6	1	5	1	6	2	2			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr8:145139221G>A	uc003zax.2	+	6	911	c.801G>A	c.(799-801)ACG>ACA	p.T267T	GPAA1_uc003zav.1_Silent_p.T145T|GPAA1_uc003zaw.1_Silent_p.T207T	NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	267	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGTTGTGCACGCTTCAGGGCA	0.627													17	48					0	0	0	0	A	145139221	A	A	145139221	2	1	291	1	0	0	0	0	0	0	0	1	6625	1074	38	1		1	GPAA1	8	145139221	Silent	SNP	G	TCGA-DQ-7591-01A-11D-2078-08	102943017	145139221	1224801	15	53831											
NFKBIL2	4796	broad.mit.edu	37	chr8	145655883	145655883	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatctcagggttggcagacaGatccagtgagatgagtgagg	11	8	16	6	0	1	5	1	3	1	3	3	7	2	5	1	3	0	2	1	3	0	1			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr8:145655883G>A	uc011llg.1	-	25	3862	c.3847C>T	c.(3847-3849)CTG>TTG	p.L1283L	VPS28_uc003zcs.1_5'Flank|VPS28_uc003zct.1_5'Flank	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	1283	LRR 6.				cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TTGGCAGACAGATCCAGTGAG	0.557													6	12					0	0	0	0	A	145655883	A	A	145655883	2	1	291	1	0	0	0	0	0	0	0	1	10436	933	33	2		2	NFKBIL2	8	145655883	Silent	SNP	G	TCGA-DQ-7591-01A-11D-2078-08	516662	145655883	708139	16	53832											
C9orf79	286234	broad.mit.edu	37	chr9	90501079	90501079	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggagaggacacagtctgtCatccccactggaaaggagta	13	6	12	10	0	2	1	1	0	1	1	3	5	3	4	2	4	0	1	2	4	2	1			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr9:90501079C>T	uc004app.3	+	4	1712	c.1677C>T	c.(1675-1677)GTC>GTT	p.V559V	C9orf79_uc004apo.1_Silent_p.V371V	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	559						integral to membrane				ovary(3)	3						CACAGTCTGTCATCCCCACTG	0.483													11	139					0	0	0	0	T	90501079	T	T	90501079	2	4	291	1	0	0	0	0	0	0	0	1	2509	813	29	2		2	C9orf79	9	90501079	Silent	SNP	C	TCGA-DQ-7591-01A-11D-2078-08		90501079	50712352	17	53833											
WDR5	11091	broad.mit.edu	37	chr9	137005026	137005026	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggaggagaagaagcccgaGaccgaggccgccagagcaca	14	0	15	12	4	0	4	0	0	0	4	0	8	0	5	4	3	2	1	4	3	2	0			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr9:137005026G>C	uc004cey.2	+	2	198	c.27G>C	c.(25-27)GAG>GAC	p.E9D	WDR5_uc004cez.2_Missense_Mutation_p.E9D	NM_017588	NP_060058	P61964	WDR5_HUMAN	WD repeat domain 5	9					histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding				0		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		AGAAGCCCGAGACCGAGGCCG	0.657													11	22					0	0	0	0	C	137005026	C	C	137005026	3	2	291	1	0	0	0	0	1	0	0	0	17371	933	33	2	29	2	WDR5	9	137005026	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08	46503947	137005026	4208405	18	53834											
ARID5B	84159	broad.mit.edu	37	chr10	63851924	63851924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcggcagcagaagcccctaCggatgatcagcctacagatc	11	5	12	13	2	1	3	1	1	0	2	2	4	1	4	3	3	5	2	3	3	3	2			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr10:63851924C>T	uc001jlt.1	+	10	2728	c.2702C>T	c.(2701-2703)ACG>ATG	p.T901M		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	901					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GAAGCCCCTACGGATGATCAG	0.552													28	46					0	0	0	0	T	63851924	T	T	63851924	3	4	291	1	0	0	0	0	1	0	0	0	922	536	19	1	2740	1	ARID5B	10	63851924	Missense_Mutation	SNP	C	TCGA-DQ-7591-01A-11D-2078-08		63851924	71682823	19	53835											
KCNMA1	3778	broad.mit.edu	37	chr10	78708933	78708933	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actttggggaagttatgaagCgtctcccattcccgcttgag	8	12	11	10	2	1	2	0	2	1	0	3	3	2	3	2	2	1	2	2	2	3	4	rs143184179	by1000genomes	TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr10:78708933C>T	uc001jxn.2	-	22	2853	c.2676G>A	c.(2674-2676)ACG>ACA	p.T892T	KCNMA1_uc001jxj.2_Silent_p.T838T|KCNMA1_uc001jxk.1_Silent_p.T510T|KCNMA1_uc009xrt.1_Silent_p.T683T|KCNMA1_uc001jxl.1_Silent_p.T517T|KCNMA1_uc001jxo.2_Silent_p.T875T|KCNMA1_uc001jxm.2_Silent_p.T834T|KCNMA1_uc001jxq.2_Silent_p.T837T	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	892	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	AGTTATGAAGCGTCTCCCATT	0.458													5	117					0	0	0	0	T	78708933	T	T	78708933	2	4	291	1	0	0	0	0	0	0	0	1	8112	755	27	1		1	KCNMA1	10	78708933	Silent	SNP	C	TCGA-DQ-7591-01A-11D-2078-08	14857009	78708933	56825814	20	53836											
ENTPD1	953	broad.mit.edu	37	chr10	97607265	97607265	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggatataagaaggtagtgaaCgtaagtgacctttacaagac	16	9	11	5	1	0	4	0	2	0	2	0	5	0	5	1	2	2	2	1	2	8	6	rs149509898	by1000genomes	TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr10:97607265C>T	uc001klh.3	+	7	1200	c.876C>T	c.(874-876)AAC>AAT	p.N292N	ENTPD1_uc001kli.3_Silent_p.N299N|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Silent_p.N304N|ENTPD1_uc010qok.1_Silent_p.N184N|ENTPD1_uc010qol.1_Silent_p.N184N|ENTPD1_uc010qom.1_Intron|ENTPD1_uc010qon.1_Silent_p.N154N|ENTPD1_uc009xva.2_Silent_p.N154N|ENTPD1_uc009xuz.2_Intron	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	292	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		AGGTAGTGAACGTAAGTGACC	0.418													26	46					0	0	0	0	T	97607265	T	T	97607265	2	4	291	1	0	0	0	0	0	0	0	1	5162	535	19	1		1	ENTPD1	10	97607265	Silent	SNP	C	TCGA-DQ-7591-01A-11D-2078-08	18898332	97607265	37927482	21	53837											
ELP4	26610	broad.mit.edu	37	chr11	31616337	31616337	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaacttccagcaccattactTgatgataaatgtaaaaagga	17	10	7	7	0	0	2	0	2	0	0	1	4	1	3	2	1	3	2	2	1	7	5			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr11:31616337T>A	uc001mtb.2	+	4	437	c.402T>A	c.(400-402)CTT>CTA	p.L134L	ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Silent_p.L134L|ELP4_uc010rdz.1_Silent_p.L134L	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	134					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					CACCATTACTTGATGATAAAT	0.289													11	26					0	0	0	0	A	31616337	A	A	31616337	2	1	291	1	0	0	0	0	0	0	0	1	5106	1799	63	5		5	ELP4	11	31616337	Silent	SNP	T	TCGA-DQ-7591-01A-11D-2078-08		31616337	103390179	22	53838											
QSER1	79832	broad.mit.edu	37	chr11	32955375	32955375	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aatacacaggtccttttagaTtctgcctgtgatttacaaat	12	15	6	8	0	1	2	0	1	1	1	2	2	2	2	2	1	3	0	2	1	5	6			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr11:32955375T>A	uc001mty.2	+	4	2451	c.2184T>A	c.(2182-2184)GAT>GAA	p.D728E	QSER1_uc001mtz.1_Missense_Mutation_p.D489E|QSER1_uc001mua.2_Missense_Mutation_p.D233E	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	728	Gln-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					TCCTTTTAGATTCTGCCTGTG	0.408													28	49					0	0	0	0	A	32955375	A	A	32955375	3	1	291	1	0	0	0	0	1	0	0	0	12947	1490	52	5	2190	5	QSER1	11	32955375	Missense_Mutation	SNP	T	TCGA-DQ-7591-01A-11D-2078-08	1339038	32955375	102051141	23	53839											
ABTB2	25841	broad.mit.edu	37	chr11	34176283	34176283	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtggggatctccatggattCtgttcctccgtagtacagat	7	13	12	9	1	2	1	0	0	2	1	5	3	4	3	3	4	1	3	3	4	2	4			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr11:34176283C>T	uc001mvl.1	-	15	2403	c.2173G>A	c.(2173-2175)GAA>AAA	p.E725K		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	725							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				TCCATGGATTCTGTTCCTCCG	0.592													24	45					0	0	0	0	T	34176283	T	T	34176283	3	4	291	1	0	0	0	0	1	0	0	0	103	922	32	2	358	2	ABTB2	11	34176283	Missense_Mutation	SNP	C	TCGA-DQ-7591-01A-11D-2078-08	1220908	34176283	100830233	24	53840											
OR5L1	219437	broad.mit.edu	37	chr11	55578997	55578997	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcattctccttggactatcaGatgtccctgagttgagagtc	8	14	9	10	0	3	3	2	2	1	2	6	5	4	4	2	1	0	1	2	1	1	4			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr11:55578997G>A	uc001nhw.1	+	1	55	c.55G>A	c.(55-57)GAT>AAT	p.D19N		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TGGACTATCAGATGTCCCTGA	0.443													14	113					0	0	0	0	A	55578997	A	A	55578997	3	1	291	1	0	0	0	0	1	0	0	0	11224	942	33	2	57	2	OR5L1	11	55578997	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08	21402714	55578997	79427519	25	53841											
NOX4	50507	broad.mit.edu	37	chr11	89088181	89088181	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaatttcggagtcttgactaGatggaggcagtagtaaatct	12	12	12	5	1	2	2	0	1	2	1	3	5	2	4	0	3	0	3	0	3	5	5			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr11:89088181G>C	uc001pct.2	-	13	1405	c.1166C>G	c.(1165-1167)TCT>TGT	p.S389C	NOX4_uc009yvr.2_Missense_Mutation_p.S364C|NOX4_uc001pcu.2_Missense_Mutation_p.S315C|NOX4_uc001pcw.2_Missense_Mutation_p.S82C|NOX4_uc001pcx.2_Missense_Mutation_p.S82C|NOX4_uc001pcv.2_Missense_Mutation_p.S389C|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Missense_Mutation_p.S223C|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Missense_Mutation_p.S365C|NOX4_uc009yvq.2_Missense_Mutation_p.S365C	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	389	FAD-binding FR-type.|Extracellular (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				GTCTTGACTAGATGGAGGCAG	0.363													6	22					0	0	0	0	C	89088181	C	C	89088181	3	2	291	1	0	0	0	0	1	0	0	0	10612	942	33	2	594	2	NOX4	11	89088181	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08	33509184	89088181	45918335	26	53842											
IQSEC3	440073	broad.mit.edu	37	chr12	247484	247484	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acctggtgtcccggcgcgccGcttgcaccatccaaaccgcc	6	6	10	19	5	0	0	0	0	0	0	2	0	2	0	7	2	2	2	7	2	1	1			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr12:247484G>A	uc001qhw.1	+	1	52	c.46G>A	c.(46-48)GCT>ACT	p.A16T	IQSEC3_uc001qhu.1_Missense_Mutation_p.A16T|IQSEC3_uc001qht.1_Missense_Mutation_p.A101T|uc001qhv.1_RNA	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	319	IQ.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CCGGCGCGCCGCTTGCACCAT	0.592													8	128					0	0	0	0	A	247484	A	A	247484	3	1	291	1	0	0	0	0	1	0	0	0	7858	1087	38	1	969	1	IQSEC3	12	247484	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08		247484	133604411	27	53843											
PGAM5	192111	broad.mit.edu	37	chr12	133294060	133294060	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aactcactgggctccgcctgGcaagcttggggttgaagttt	7	11	13	10	1	1	1	1	1	0	0	2	1	2	1	2	4	2	5	2	4	3	3			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr12:133294060G>A	uc009zyv.2	+	3	433	c.406G>A	c.(406-408)GCA>ACA	p.A136T	PGAM5_uc010tbr.1_RNA|PGAM5_uc001uku.2_Missense_Mutation_p.A136T	NM_138575	NP_612642	Q96HS1	PGAM5_HUMAN	phosphoglycerate mutase family member 5	136						integral to membrane|mitochondrial outer membrane	phosphoprotein phosphatase activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.89e-08)|Epithelial(86;1.14e-07)|all cancers(50;3.57e-06)		GCTCCGCCTGGCAAGCTTGGG	0.453													3	31					0	0	0	0	A	133294060	A	A	133294060	3	1	291	1	0	0	0	0	1	0	0	0	11831	1203	42	4	416	4	PGAM5	12	133294060	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08	133046576	133294060	557835	28	53844											
NALCN	259232	broad.mit.edu	37	chr13	101997763	101997763	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gaatagctaaactattccagGttacattcctgtgaacaaca	15	11	6	9	0	0	1	0	1	0	0	2	2	2	1	2	1	5	2	2	1	8	6			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr13:101997763G>T	uc001vox.1	-	7	842	c.653C>A	c.(652-654)ACC>AAC	p.T218N	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.T218N|NALCN_uc001vpa.2_Missense_Mutation_p.T218N	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	218	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACTATTCCAGGTTACATTCCT	0.373													20	34					5.03518e-11	5.51934e-11	1	0	T	101997763	T	T	101997763	3	4	291	1	0	0	0	0	1	0	0	0	10201	1261	44	4	4715	4	NALCN	13	101997763	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08		101997763	13172115	29	53845											
FBLN5	10516	broad.mit.edu	37	chr14	92336584	92336584	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggctcagaatgggtactgcGacacatatatccgcagtcgg	11	8	12	10	3	1	1	1	0	0	1	3	2	2	1	1	3	2	3	1	3	4	3			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr14:92336584G>A	uc001xzx.3	-	11	1804	c.1331C>T	c.(1330-1332)TCG>TTG	p.S444L	TC2N_uc001xzv.3_5'Flank|FBLN5_uc010aud.2_Missense_Mutation_p.S449L|FBLN5_uc010aue.2_Missense_Mutation_p.S485L|FBLN5_uc001xzw.2_RNA	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	444					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				TGGGTACTGCGACACATATAT	0.542													26	51					0	0	0	0	A	92336584	A	A	92336584	3	1	291	1	0	0	0	0	1	0	0	0	5732	1059	37	1	19	1	FBLN5	14	92336584	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08		92336584	15012956	30	53846											
HERC2	8924	broad.mit.edu	37	chr15	28375741	28375741	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaccagtaagagaatcaatCtagagggggaaaaggttcaa	18	6	12	5	0	3	3	2	0	1	3	3	5	3	4	1	3	0	2	1	3	7	3			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr15:28375741C>T	uc001zbj.2	-	82	12677	c.12571_splice	c.e82-1	p.I4191_splice		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GAGAATCAATCTAGAGGGGGA	0.413													43	72					0	0	0	0	T	28375741	T	T	28375741	5	4	291	1	0	0	0	0	0	0	1	0	7097	927	32	2	1982	2	HERC2	15	28375741	Splice_Site	SNP	C	TCGA-DQ-7591-01A-11D-2078-08		28375741	74155651	31	53847											
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42133017	42133017	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accaggacctggtgaccggaGatgaccctgtgttgtcagta	9	9	13	10	1	1	3	1	2	0	1	1	5	1	4	4	3	0	2	4	3	1	2			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr15:42133017G>T	uc010bco.2	+	4	366	c.265G>T	c.(265-267)GAT>TAT	p.D89Y	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.D320Y|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.D320Y|JMJD7-PLA2G4B_uc001zoq.3_5'UTR|JMJD7-PLA2G4B_uc001zor.1_5'Flank	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	89	C2.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						GGTGACCGGAGATGACCCTGT	0.577													29	41					3.73148e-12	4.17047e-12	1	0	T	42133017	T	T	42133017	3	4	291	1	0	0	0	0	1	0	0	0	7994	942	33	2	992	2	JMJD7-PLA2G4B	15	42133017	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08	13757276	42133017	60398375	32	53848											
GCOM1	145781	broad.mit.edu	37	chr15	57913836	57913836	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctttggaaaaggtgagaaagCgaatgtatggagactatgat	15	10	13	3	1	0	3	0	2	0	2	0	7	0	4	0	3	1	1	0	3	6	3			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr15:57913836C>T	uc002aei.2	+	4	468	c.349C>T	c.(349-351)CGA>TGA	p.R117*	GCOM1_uc002aej.2_Nonsense_Mutation_p.R117*|GCOM1_uc002aek.2_Intron|GCOM1_uc002ael.2_Intron|GCOM1_uc002aem.2_Nonsense_Mutation_p.R117*|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Nonsense_Mutation_p.R117*|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	117	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						GGTGAGAAAGCGAATGTATGG	0.403													23	53					0	0	0	0	T	57913836	T	T	57913836	4	4	291	1	0	0	0	0	0	1	0	0	6340	760	27	1	363	1	GCOM1	15	57913836	Nonsense_Mutation	SNP	C	TCGA-DQ-7591-01A-11D-2078-08	15780819	57913836	44617556	33	53849											
BTBD12	84464	broad.mit.edu	37	chr16	3645643	3645643	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtccgggtgcttgtcctgcGatggcaccacaaacccagtc	7	9	11	14	2	0	0	0	0	0	0	3	1	2	0	4	2	3	2	4	2	1	1			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr16:3645643G>A	uc002cvp.2	-	9	2603	c.1976C>T	c.(1975-1977)TCG>TTG	p.S659L		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	659	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CTTGTCCTGCGATGGCACCAC	0.632								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				9	21					0	0	0	0	A	3645643	A	A	3645643	3	1	291	1	0	0	0	0	1	0	0	0	1545	1059	37	1	3556	1	BTBD12	16	3645643	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08		3645643	86709110	34	53850											
SMG1	23049	broad.mit.edu	37	chr16	18856797	18856807	+	Frame_Shift_Del	DEL	GGAGTCTTCAG	-	-																															caggctttgcagggttcaatGgagtcttcagtttttctagg																										TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr16:18856797_18856807delGGAGTCTTCAG	uc002dfm.2	-	39	6526_6536	c.6163_6173delCTGAAGACTCC	c.(6163-6174)CTGAAGACTCCAfs	p.L2055fs	SMG1_uc010bwb.2_Frame_Shift_Del_p.L1915fs|SMG1_uc010bwa.2_Frame_Shift_Del_p.L786fs|SMG1_uc002dfo.3_Frame_Shift_Del_p.L353fs	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2055_2058					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						AGGGTTCAATGGAGTCTTCAGTTTTTCTAGG	0.455													---	---	---								-	18856807	-	-	18856797	7	5	291	1	0	1	0	1	0	0	0	0	14859	1348	47	0	4912	0	SMG1	16	18856797	Frame_Shift_Del	DEL	GGAGTCTTCAG	TCGA-DQ-7591-01A-11D-2078-08	15211154	18856797	71497956	35	53851											
CDH11	1009	broad.mit.edu	37	chr16	65032649	65032649	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttctcgatccaacgtcttGgtggcatgaatgttccctga	7	14	9	11	2	3	2	0	2	3	0	6	3	5	2	2	2	1	2	2	2	2	3			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr16:65032649G>A	uc002eoi.2	-	4	773	c.339C>T	c.(337-339)ACC>ACT	p.T113T	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.T113T|CDH11_uc010vin.1_5'UTR|CDH11_uc010vio.1_Silent_p.T113T	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	113	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCAACGTCTTGGTGGCATGAA	0.493			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			10	6					0	0	0	0	A	65032649	A	A	65032649	2	1	291	1	0	0	0	0	0	0	0	1	3112	1335	47	4		4	CDH11	16	65032649	Silent	SNP	G	TCGA-DQ-7591-01A-11D-2078-08	46175852	65032649	25322104	36	53852											
MYH2	4620	broad.mit.edu	37	chr17	10448712	10448712	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagatggagaagatgtggggCggggcctcctggcgcttttt	6	10	18	7	2	0	3	0	0	0	3	1	5	1	3	2	6	0	1	2	6	1	2			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr17:10448712C>T	uc010coi.2	-	5	584	c.456G>A	c.(454-456)CCG>CCA	p.P152P	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.P152P|MYH2_uc010coj.2_Silent_p.P152P	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	152	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AGATGTGGGGCGGGGCCTCCT	0.542													10	96					0	0	0	0	T	10448712	T	T	10448712	2	4	291	1	0	0	0	0	0	0	0	1	10088	755	27	1		1	MYH2	17	10448712	Silent	SNP	C	TCGA-DQ-7591-01A-11D-2078-08		10448712	70746498	37	53853											
KIAA0100	9703	broad.mit.edu	37	chr17	26971123	26971123	+	Frame_Shift_Del	DEL	A	-	-																															aagactgacattctggatccAaaaaaagcggaaggagccaa																										TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr17:26971123delA	uc002hbu.2	-	2	250	c.151delT	c.(151-153)TGGfs	p.W51fs	KIAA0100_uc002hbv.2_Frame_Shift_Del_p.W51fs|KIAA0100_uc010crr.1_5'UTR	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	51						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TTCTGGATCCAAAAAAAGCGG	0.478											OREG0024280	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	26971123	-	-	26971123	7	5	291	1	0	1	0	1	0	0	0	0	8193	130	5	0	6708	0	KIAA0100	17	26971123	Frame_Shift_Del	DEL	A	TCGA-DQ-7591-01A-11D-2078-08	16522411	26971123	54224087	38	53854											
CA4	762	broad.mit.edu	37	chr17	58233927	58233927	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctccctgctcagtgccagTcaagtggggtggaaactgcc	7	9	12	13	0	3	0	2	0	1	0	4	1	3	1	3	3	4	1	3	3	2	0			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr17:58233927T>C	uc002iym.3	+	3	213	c.119T>C	c.(118-120)GTC>GCC	p.V40A	CA4_uc010wou.1_RNA	NM_000717	NP_000708	P22748	CAH4_HUMAN	carbonic anhydrase IV precursor	40					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TCAGTGCCAGTCAAGTGGGGT	0.587													17	35					0	0	0	0	C	58233927	C	C	58233927	3	2	291	1	0	0	0	0	1	0	0	0	2530	1667	58	5	129	5	CA4	17	58233927	Missense_Mutation	SNP	T	TCGA-DQ-7591-01A-11D-2078-08	31262804	58233927	22961283	39	53855											
SLC14A1	6563	broad.mit.edu	37	chr18	43319570	43319570	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctctctggcctgcattgcaAtgggaggaatgttcatggcg	7	11	14	9	1	2	0	1	0	1	0	3	2	2	2	1	4	2	4	1	4	2	2			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr18:43319570A>G	uc010xcn.1	+	9	1208	c.889A>G	c.(889-891)ATG>GTG	p.M297V	SLC14A1_uc010dnk.2_Missense_Mutation_p.M353V|SLC14A1_uc002lbf.3_Missense_Mutation_p.M297V|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Missense_Mutation_p.M192V|SLC14A1_uc002lbh.3_Missense_Mutation_p.M189V|SLC14A1_uc002lbi.3_Missense_Mutation_p.M165V|SLC14A1_uc002lbj.3_Missense_Mutation_p.M353V|SLC14A1_uc002lbk.3_Missense_Mutation_p.M297V	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	297	Helical; (Potential).					integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						CTGCATTGCAATGGGAGGAAT	0.562													26	44					0	0	0	0	G	43319570	G	G	43319570	3	3	291	1	0	0	0	0	1	0	0	0	14461	101	4	5	1083	5	SLC14A1	18	43319570	Missense_Mutation	SNP	A	TCGA-DQ-7591-01A-11D-2078-08		43319570	34757678	40	53856											
ZNRF4	148066	broad.mit.edu	37	chr19	5456253	5456253	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgacctgggctgtcaccccGtgctgaccgtgtcctgggtg	4	9	14	14	3	1	1	1	1	0	0	2	2	2	1	5	2	1	2	5	2	0	0	rs113345491		TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr19:5456253G>A	uc002mca.3	+	1	828	c.751G>A	c.(751-753)GTG>ATG	p.V251M		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	251	Helical; (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CTGTCACCCCGTGCTGACCGT	0.682													25	19					0	0	0	0	A	5456253	A	A	5456253	3	1	291	1	0	0	0	0	1	0	0	0	18281	1145	40	1	753	1	ZNRF4	19	5456253	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08		5456253	53672730	41	53857											
ZNF835	90485	broad.mit.edu	37	chr19	57175924	57175924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccgctcgcccgtgtgcaCgcgccggtgctgggtcaggt	2	7	18	14	6	1	0	1	0	0	0	2	0	1	0	3	4	2	3	3	4	0	0			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr19:57175924C>T	uc010ygo.1	-	2	709	c.709G>A	c.(709-711)GTG>ATG	p.V237M	ZNF835_uc010ygn.1_Missense_Mutation_p.V215M	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CCCGTGTGCACGCGCCGGTGC	0.716													5	9					0	0	0	0	T	57175924	T	T	57175924	3	4	291	1	0	0	0	0	1	0	0	0	18253	536	19	1	972	1	ZNF835	19	57175924	Missense_Mutation	SNP	C	TCGA-DQ-7591-01A-11D-2078-08	51719671	57175924	1953059	42	53858											
RALGAPA2	57186	broad.mit.edu	37	chr20	20506898	20506898	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagaaaaaaagacttacttCtgccattttccgaggcagag	15	9	8	9	1	1	3	0	0	1	3	2	4	2	3	2	1	2	1	2	1	4	4			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr20:20506898C>T	uc002wrz.2	-	28	3834	c.3691G>A	c.(3691-3693)GAA>AAA	p.E1231K	RALGAPA2_uc010gcx.2_Missense_Mutation_p.E935K|RALGAPA2_uc010zsg.1_Missense_Mutation_p.E679K|RALGAPA2_uc002wsa.1_Missense_Mutation_p.E3K	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1231					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						AGACTTACTTCTGCCATTTTC	0.353													7	11					0	0	0	0	T	20506898	T	T	20506898	3	4	291	1	0	0	0	0	1	0	0	0	13079	922	32	2	1978	2	RALGAPA2	20	20506898	Missense_Mutation	SNP	C	TCGA-DQ-7591-01A-11D-2078-08		20506898	42518622	43	53859											
BIK	638	broad.mit.edu	37	chr22	43524565	43524565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgttcttagaagtttcatGgacggtttcaccacacttaa	11	14	8	8	1	3	1	2	0	1	1	3	3	3	2	1	2	0	3	1	2	3	5			TCGA-DQ-7591-01A-11D-2078-08	TCGA-DQ-7591-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	4068a2fc-452d-4b2c-88d8-72d30097527b	91a5e873-7f52-493c-8b6c-95933c192325	g.chr22:43524565G>A	uc003bdk.2	+	4	384	c.324G>A	c.(322-324)ATG>ATA	p.M108I		NM_001197	NP_001188	Q13323	BIK_HUMAN	BCL2-interacting killer	108					apoptosis|induction of apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	endomembrane system|integral to membrane					0		Ovarian(80;0.0694)				GAAGTTTCATGGACGGTTTCA	0.512													27	67					0	0	0	0	A	43524565	A	A	43524565	3	1	291	1	0	0	0	0	1	0	0	0	1434	1348	47	4	334	4	BIK	22	43524565	Missense_Mutation	SNP	G	TCGA-DQ-7591-01A-11D-2078-08		43524565	7780001	44	53860											
CDC42	998	broad.mit.edu	37	chr1	22413014	22413014	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtttttcagtggtctctccAtcttcatttgaaaacgtgaa	9	17	7	8	1	4	2	2	2	2	0	6	2	5	2	1	1	1	1	1	1	3	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:22413014A>G	uc001bfq.2	+	5	553	c.261A>G	c.(259-261)CCA>CCG	p.P87P	CDC42_uc009vqg.1_Silent_p.P87P|CDC42_uc001bfp.2_Silent_p.P87P|CDC42_uc001bfr.2_Silent_p.P87P|CDC42_uc010odr.1_Silent_p.P132P|CDC42_uc010ods.1_Silent_p.P129P|CDC42_uc009vqh.2_Silent_p.P46P	NM_001039802	NP_001034891	P60953	CDC42_HUMAN	cell division cycle 42 isoform 1	87					actin cytoskeleton organization|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|establishment or maintenance of cell polarity|macrophage differentiation|muscle cell differentiation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of protein complex assembly|positive regulation of muscle cell differentiation|positive regulation of pseudopodium assembly|regulation of filopodium assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|filopodium|plasma membrane	GTP binding|GTPase activity|protein binding|thioesterase binding			haematopoietic_and_lymphoid_tissue(1)	1		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)|Prostate(1639;0.0792)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0452)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.35e-07)|COAD - Colon adenocarcinoma(152;7.73e-06)|GBM - Glioblastoma multiforme(114;8.62e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000649)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00767)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.207)		TGGTCTCTCCATCTTCATTTG	0.358													29	33					0	0	0	0	G	22413014	G	G	22413014	2	3	292	1	0	0	0	0	0	0	0	1	3086	204	8	5		5	CDC42	1	22413014	Silent	SNP	A	TCGA-DQ-7592-01A-11D-2078-08		22413014	226837607	1	53861											
CSMD2	114784	broad.mit.edu	37	chr1	34033207	34033207	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acttacgcacacagaaagggGtcttgcccgaccagtgatga	12	7	11	11	2	1	3	0	2	1	1	1	4	1	3	2	2	2	1	2	2	2	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:34033207G>T	uc001bxn.1	-	54	8326	c.8297C>A	c.(8296-8298)ACC>AAC	p.T2766N	CSMD2_uc001bxm.1_Missense_Mutation_p.T2789N	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2766	Sushi 18.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACAGAAAGGGGTCTTGCCCGA	0.527													10	32					4.68919e-08	5.39967e-08	1	0	T	34033207	T	T	34033207	3	4	292	1	0	0	0	0	1	0	0	0	3962	1261	44	4	2230	4	CSMD2	1	34033207	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	11620193	34033207	215217414	2	53862											
ZFYVE9	9372	broad.mit.edu	37	chr1	52810541	52810541	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaagctttttgccttgctctCtgtcctcacctgaaacttct	7	16	5	13	0	3	1	1	1	2	0	5	1	4	1	3	0	4	2	3	0	2	4	rs145347233		TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:52810541C>G	uc001cto.2	+	18	4213	c.4041C>G	c.(4039-4041)CTC>CTG	p.L1347L	ZFYVE9_uc001ctp.2_Silent_p.L1288L	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	1347					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						GCCTTGCTCTCTGTCCTCACC	0.453													33	70					0	0	0	0	G	52810541	G	G	52810541	2	3	292	1	0	0	0	0	0	0	0	1	17738	900	32	2		2	ZFYVE9	1	52810541	Silent	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	18777334	52810541	196440080	3	53863											
SGIP1	84251	broad.mit.edu	37	chr1	67147692	67147692	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtccatttttctgatacaTccccggaacatgttactccg	8	13	8	12	2	1	1	0	1	1	0	4	2	4	2	4	2	3	1	4	2	3	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:67147692T>A	uc001dcr.2	+	15	1172	c.955T>A	c.(955-957)TCC>ACC	p.S319T	SGIP1_uc010opd.1_Intron|SGIP1_uc001dcs.2_Intron|SGIP1_uc001dct.2_Intron|SGIP1_uc009wat.2_Missense_Mutation_p.S86T	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	319	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TTCTGATACATCCCCGGAACA	0.507													33	74					0	0	0	0	A	67147692	A	A	67147692	3	1	292	1	0	0	0	0	1	0	0	0	14271	1435	50	5	1013	5	SGIP1	1	67147692	Missense_Mutation	SNP	T	TCGA-DQ-7592-01A-11D-2078-08	14337151	67147692	182102929	4	53864											
ZNF326	284695	broad.mit.edu	37	chr1	90484343	90484343	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaaaagatgttatggaaGgtaagtatttaaaacaaatt	19	13	8	1	0	0	2	0	1	0	1	0	3	0	3	0	2	1	3	0	2	9	7			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:90484343G>T	uc001dnq.2	+	9	1313	c.1174G>T	c.(1174-1176)GGT>TGT	p.G392C	ZNF326_uc009wda.1_Missense_Mutation_p.G303C|ZNF326_uc001dnr.2_Missense_Mutation_p.G186C	NM_182976	NP_892021	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326 isoform 1	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			ovary(1)	1		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		TGTTATGGAAGGTAAGTATTT	0.254													6	24					5.9392e-07	6.63793e-07	1	0	T	90484343	T	T	90484343	3	4	292	1	0	0	0	0	1	0	0	0	17913	1014	35	4	1212	4	ZNF326	1	90484343	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	23336651	90484343	158766278	5	53865											
TMEM206	55248	broad.mit.edu	37	chr1	212583778	212583778	+	Frame_Shift_Del	DEL	C	-	-																															cgcactcacctggtaagataCccggaccttggactctgacc																										TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:212583778delC	uc001hjc.3	-	2	290	c.122delG	c.(121-123)GGTfs	p.G41fs	TMEM206_uc010pte.1_Frame_Shift_Del_p.G102fs	NM_018252	NP_060722	Q9H813	TM206_HUMAN	transmembrane protein 206	41	Cytoplasmic (Potential).					integral to membrane				breast(1)	1				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		TGGTAAGATACCCGGACCTTG	0.582													---	---	---								-	212583778	-	-	212583778	7	5	292	1	0	1	0	1	0	0	0	0	16197	507	18	0	958	0	TMEM206	1	212583778	Frame_Shift_Del	DEL	C	TCGA-DQ-7592-01A-11D-2078-08	122099435	212583778	36666843	6	53866											
USH2A	7399	broad.mit.edu	37	chr1	216258090	216258090	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaagcgggacatccctccCagctgttatacacgttgatt	10	11	9	11	2	0	2	0	2	0	0	2	3	2	3	2	1	3	3	2	1	3	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:216258090C>T	uc001hku.1	-	25	5504	c.5117G>A	c.(5116-5118)TGG>TAG	p.W1706*		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1706	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACATCCCTCCCAGCTGTTATA	0.408										HNSCC(13;0.011)			8	57					0	0	0	0	T	216258090	T	T	216258090	4	4	292	1	0	0	0	0	0	1	0	0	17104	595	21	4	10683	4	USH2A	1	216258090	Nonsense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	3674312	216258090	32992531	7	53867											
DISP1	84976	broad.mit.edu	37	chr1	223178344	223178344	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acctctggcttcccacagctGcactgcccctgagaagacca	9	7	8	17	0	1	2	0	1	1	2	2	3	2	2	5	1	3	3	5	1	1	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:223178344G>C	uc001hnu.1	+	8	3752	c.3605G>C	c.(3604-3606)TGC>TCC	p.C1202S		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1202					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TCCCACAGCTGCACTGCCCCT	0.443													8	43					0	0	0	0	C	223178344	C	C	223178344	3	2	292	1	0	0	0	0	1	0	0	0	4561	1319	46	4	3631	4	DISP1	1	223178344	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	6920254	223178344	26072277	8	53868											
CEP170	9859	broad.mit.edu	37	chr1	243388581	243388581	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaccaggatgttaagctcAttttctgcttagcttctaag	12	14	7	8	0	3	0	1	0	2	0	3	1	3	1	1	1	4	4	1	1	5	6			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:243388581A>G	uc001hzs.2	-	2	410	c.2T>C	c.(1-3)ATG>ACG	p.M1T	CEP170_uc001hzt.2_Missense_Mutation_p.M1T|CEP170_uc001hzu.2_Missense_Mutation_p.M1T	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TGTTAAGCTCATTTTCTGCTT	0.413													3	10					0	0	0	0	G	243388581	G	G	243388581	3	3	292	1	0	0	0	0	1	0	0	0	3265	217	8	5	4858	5	CEP170	1	243388581	Missense_Mutation	SNP	A	TCGA-DQ-7592-01A-11D-2078-08	20210237	243388581	5862040	9	53869											
OR2T11	127077	broad.mit.edu	37	chr1	248790244	248790244	+	Silent	SNP	C	T	T																															agggtgtccatgatggacagCtgactgagcagaaagtacat																										TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:248790244C>T	uc001ier.1	-	1	186	c.186G>A	c.(184-186)CAG>CAA	p.Q62Q		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGATGGACAGCTGACTGAGCA	0.483													12	32					0	0	0	0	T	248790244	T	T	248790244	2	4	292	1	0	0	0	0	0	0	0	1	11072	796	28	4		4	OR2T11	1	248790244	Silent	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	5401663	248790244	460377	10	53870	125	2									
OR2T11	127077	broad.mit.edu	37	chr1	248790246	248790246	+	Missense_Mutation	SNP	G	T	T																															ggtgtccatgatggacagctGactgagcagaaagtacatgg																										TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr1:248790246G>T	uc001ier.1	-	1	184	c.184C>A	c.(184-186)CAG>AAG	p.Q62K		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGGACAGCTGACTGAGCAGA	0.488													12	32					3.07112e-06	3.36642e-06	1	0	T	248790246	T	T	248790246	3	4	292	1	0	0	0	0	1	0	0	0	11072	1299	45	2	770	2	OR2T11	1	248790246	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	2	248790246	460375	11	53871	125	2									
DTNB	1838	broad.mit.edu	37	chr2	25803661	25803661	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggaggagggtcagccatcAttgtgtctaaaaacatattt	12	11	12	6	0	3	0	2	0	1	0	3	2	3	2	1	4	2	0	1	4	4	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr2:25803661A>C	uc002rgh.2	-	7	888	c.638T>G	c.(637-639)ATG>AGG	p.M213R	DTNB_uc010yko.1_Missense_Mutation_p.M156R|DTNB_uc010ykp.1_Missense_Mutation_p.M9R|DTNB_uc002rgo.2_Missense_Mutation_p.M34R|DTNB_uc002rgi.2_Missense_Mutation_p.M213R|DTNB_uc002rgj.2_Missense_Mutation_p.M213R|DTNB_uc002rgk.2_Missense_Mutation_p.M213R|DTNB_uc002rgl.2_Missense_Mutation_p.M213R|DTNB_uc002rgq.2_Missense_Mutation_p.M213R|DTNB_uc002rgm.2_Missense_Mutation_p.M213R|DTNB_uc002rgn.2_Missense_Mutation_p.M9R|DTNB_uc002rgr.1_Missense_Mutation_p.M202R|DTNB_uc010ykq.1_Missense_Mutation_p.M66R	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	213						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCAGCCATCATTGTGTCTAA	0.383													5	53					0	0	0	0	C	25803661	C	C	25803661	3	2	292	1	0	0	0	0	1	0	0	0	4811	217	8	5	1301	5	DTNB	2	25803661	Missense_Mutation	SNP	A	TCGA-DQ-7592-01A-11D-2078-08		25803661	217395712	12	53872											
ACOXL	55289	broad.mit.edu	37	chr2	111666433	111666433	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agcaccaaacacagaccctgCggctgatgccccacctggcc	10	4	9	18	1	0	2	0	1	0	1	0	2	0	2	6	2	4	2	6	2	1	0			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr2:111666433C>T	uc002tgr.3	+	11	1080	c.856C>T	c.(856-858)CGG>TGG	p.R286W	ACOXL_uc010fkc.2_Missense_Mutation_p.R286W|ACOXL_uc010yxk.1_Missense_Mutation_p.R286W	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	286					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						ACAGACCCTGCGGCTGATGCC	0.547													9	49					0	0	0	0	T	111666433	T	T	111666433	3	4	292	1	0	0	0	0	1	0	0	0	161	759	27	1	894	1	ACOXL	2	111666433	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	85862772	111666433	131532940	13	53873											
AGPS	8540	broad.mit.edu	37	chr2	178326624	178326624	+	Frame_Shift_Del	DEL	A	-	-																															aaatttttgtttttcagcttAaagaaagtggttattgtaca																										TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr2:178326624delA	uc002ull.2	+	9	921	c.874delA	c.(874-876)AAAfs	p.K292fs	AGPS_uc010zfb.1_Frame_Shift_Del_p.K202fs	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	292	FAD-binding PCMH-type.				ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			TTTTCAGCTTAAAGAAAGTGG	0.383													---	---	---								-	178326624	-	-	178326624	7	5	292	1	0	1	0	1	0	0	0	0	394	363	13	0	908	0	AGPS	2	178326624	Frame_Shift_Del	DEL	A	TCGA-DQ-7592-01A-11D-2078-08	66660191	178326624	64872749	14	53874											
MAP2	4133	broad.mit.edu	37	chr2	210559034	210559034	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgcctagattccatagccCttggatttaactttggtcgg	7	15	9	10	1	0	1	0	0	0	1	2	2	1	2	3	3	3	0	3	3	3	8			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr2:210559034C>G	uc002vde.1	+	7	2388	c.2140C>G	c.(2140-2142)CTT>GTT	p.L714V	MAP2_uc002vdc.1_Missense_Mutation_p.L714V|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.L710V	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	714					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TTCCATAGCCCTTGGATTTAA	0.443													46	75					0	0	0	0	G	210559034	G	G	210559034	3	3	292	1	0	0	0	0	1	0	0	0	9288	681	24	4	2154	4	MAP2	2	210559034	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	32232410	210559034	32640339	15	53875											
CCBP2	1238	broad.mit.edu	37	chr3	42906038	42906038	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gccactcgccactgaggatgCcgattctgagaatagcagct	10	8	11	12	2	1	2	0	2	1	1	2	5	1	3	3	1	3	2	3	1	2	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr3:42906038C>T	uc003cme.2	+	3	223	c.44C>T	c.(43-45)GCC>GTC	p.A15V	CCBP2_uc003cmd.1_Missense_Mutation_p.A15V|CCBP2_uc003cmf.2_Missense_Mutation_p.A15V|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	15	Extracellular (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		ACTGAGGATGCCGATTCTGAG	0.542													3	27					0	0	0	0	T	42906038	T	T	42906038	3	4	292	1	0	0	0	0	1	0	0	0	2746	739	26	4	46	4	CCBP2	3	42906038	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		42906038	155116392	16	53876											
RBM5	10181	broad.mit.edu	37	chr3	50144992	50144992	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattgctgctgctcagtggtCatccacccaggtaagatcga	9	11	10	11	1	2	1	2	0	0	1	4	2	3	1	2	2	3	4	2	2	2	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr3:50144992C>T	uc003cyg.2	+	12	1179	c.1031C>T	c.(1030-1032)TCA>TTA	p.S344L	RBM5_uc011bdj.1_Missense_Mutation_p.S288L|RBM5_uc011bdk.1_Missense_Mutation_p.S172L	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	344	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCTCAGTGGTCATCCACCCAG	0.512													14	18					0	0	0	0	T	50144992	T	T	50144992	3	4	292	1	0	0	0	0	1	0	0	0	13208	838	29	2	1073	2	RBM5	3	50144992	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	7238954	50144992	147877438	17	53877											
BBX	56987	broad.mit.edu	37	chr3	107492402	107492402	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttgtggttccaggaaatccGagaggtcttgcaaaggtgct	9	11	13	8	1	1	1	0	0	1	1	3	3	3	2	2	4	2	3	2	4	2	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr3:107492402G>A	uc010hpr.2	+	11	2161	c.1834G>A	c.(1834-1836)GAG>AAG	p.E612K	BBX_uc003dwk.3_Missense_Mutation_p.E612K|BBX_uc003dwl.3_Intron|BBX_uc010hps.1_Missense_Mutation_p.E633K|BBX_uc003dwm.3_Missense_Mutation_p.E612K|BBX_uc003dwo.3_5'Flank	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	612					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			CAGGAAATCCGAGAGGTCTTG	0.483													13	50					0	0	0	0	A	107492402	A	A	107492402	3	1	292	1	0	0	0	0	1	0	0	0	1345	1059	37	1	1864	1	BBX	3	107492402	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	57347410	107492402	90530028	18	53878											
LRRC58	116064	broad.mit.edu	37	chr3	120053938	120053938	+	Nonsense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaggatctctcgaggcagAtatgtcagcaagttattgtg	10	13	12	6	1	2	2	1	1	1	1	4	4	2	3	0	2	1	3	0	2	3	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr3:120053938A>C	uc003edr.2	-	3	774	c.678T>G	c.(676-678)TAT>TAG	p.Y226*		NM_001099678	NP_001093148	Q96CX6	LRC58_HUMAN	leucine rich repeat containing 58	226	LRR 8.										0				GBM - Glioblastoma multiforme(114;0.147)		CTCGAGGCAGATATGTCAGCA	0.363													7	37					0	0	0	0	C	120053938	C	C	120053938	4	2	292	1	0	0	0	0	0	1	0	0	9064	340	12	5	445	5	LRRC58	3	120053938	Nonsense_Mutation	SNP	A	TCGA-DQ-7592-01A-11D-2078-08	12561536	120053938	77968492	19	53879											
GTF2E1	2960	broad.mit.edu	37	chr3	120495328	120495328	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tagcaggtgggcaccaccggGaagcatgggccaccaaaggt	11	4	15	11	1	0	0	0	0	0	0	0	1	0	1	4	5	2	3	4	5	3	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr3:120495328G>T	uc003edz.3	+	4	823	c.709G>T	c.(709-711)GAA>TAA	p.E237*		NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	237					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		GCACCACCGGGAAGCATGGGC	0.458													25	66					2.00529e-23	2.38128e-23	1	0	T	120495328	T	T	120495328	4	4	292	1	0	0	0	0	0	1	0	0	6895	1175	41	2	719	2	GTF2E1	3	120495328	Nonsense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	441390	120495328	77527102	20	53880											
DNAJB8	165721	broad.mit.edu	37	chr3	128181534	128181534	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggccattgatcatctcggtGgacgacatcaccgacttgaa	10	10	10	11	3	3	2	2	2	1	0	4	5	3	3	2	3	0	0	2	3	1	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr3:128181534G>A	uc003ekk.1	-	3	2216	c.555C>T	c.(553-555)TCC>TCT	p.S185S	uc003ekl.1_5'Flank	NM_153330	NP_699161	Q8NHS0	DNJB8_HUMAN	DnaJ homolog, subfamily B, member 8	185					protein folding		heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(114;0.177)		TCATCTCGGTGGACGACATCA	0.627													15	39					0	0	0	0	A	128181534	A	A	128181534	2	1	292	1	0	0	0	0	0	0	0	1	4648	1335	47	4		4	DNAJB8	3	128181534	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	7686206	128181534	69840896	21	53881											
BFSP2	8419	broad.mit.edu	37	chr3	133119364	133119364	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctggagagcaaagccacacGctcgggaaactggggtgccc	10	4	14	13	2	0	1	0	0	0	1	1	3	0	2	3	4	4	2	3	4	2	0	rs148759360		TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr3:133119364G>T	uc003epn.1	+	1	575	c.437G>T	c.(436-438)CGC>CTC	p.R146L		NM_003571	NP_003562	Q13515	BFSP2_HUMAN	phakinin	146	Rod.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens				0						AAAGCCACACGCTCGGGAAAC	0.617													6	18					5.9392e-07	6.63793e-07	1	0	T	133119364	T	T	133119364	3	4	292	1	0	0	0	0	1	0	0	0	1419	1087	38	3	439	3	BFSP2	3	133119364	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	4937830	133119364	64903066	22	53882											
SGEF	26084	broad.mit.edu	37	chr3	153905593	153905593	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaaatactgcacaaatgAagtctaccaacaacgaacac	18	7	6	10	1	1	2	0	2	1	0	1	3	1	2	1	0	6	1	1	0	8	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr3:153905593A>T	uc011bog.1	+	7	1818	c.1607A>T	c.(1606-1608)GAA>GTA	p.E536V	SGEF_uc011boh.1_Missense_Mutation_p.E536V	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	536	DH.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGCACAAATGAAGTCTACCAA	0.343													4	18					0	0	0	0	T	153905593	T	T	153905593	3	4	292	1	0	0	0	0	1	0	0	0	14270	246	9	5	1629	5	SGEF	3	153905593	Missense_Mutation	SNP	A	TCGA-DQ-7592-01A-11D-2078-08	20786229	153905593	44116837	23	53883											
RGS12	6002	broad.mit.edu	37	chr4	3424168	3424168	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagcactgctgcattcatctCccggatgggacatcctgcgt	8	10	10	13	2	2	0	1	0	1	0	4	2	3	2	2	2	4	3	2	2	1	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr4:3424168C>T	uc003ggw.2	+	11	3808	c.2904C>T	c.(2902-2904)CTC>CTT	p.L968L	RGS12_uc003ggv.2_Silent_p.L968L|RGS12_uc003ggy.1_Silent_p.L366L|RGS12_uc003ggz.2_Silent_p.L320L|RGS12_uc010icu.1_Silent_p.L167L|RGS12_uc011bvs.1_Silent_p.L310L|RGS12_uc003gha.2_Silent_p.L310L|RGS12_uc010icv.2_Silent_p.L167L|RGS12_uc003ghb.2_Silent_p.L167L	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	968	RBD 1.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCATTCATCTCCCGGATGGGA	0.627													10	17					0	0	0	0	T	3424168	T	T	3424168	2	4	292	1	0	0	0	0	0	0	0	1	13360	842	30	2		2	RGS12	4	3424168	Silent	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		3424168	187730108	24	53884											
DRD5	1816	broad.mit.edu	37	chr4	9785061	9785061	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tttctttagacaaaataacaCctttcaccccgaatggattc	13	13	4	11	1	2	1	1	0	1	1	3	3	2	2	3	1	1	0	3	1	5	6			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr4:9785061C>G	uc003gmb.3	+	1	1804	c.1408C>G	c.(1408-1410)CCT>GCT	p.P470A		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	470	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CAAAATAACACCTTTCACCCC	0.483													7	37					0	0	0	0	G	9785061	G	G	9785061	3	3	292	1	0	0	0	0	1	0	0	0	4782	507	18	4	1410	4	DRD5	4	9785061	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	6360893	9785061	181369215	25	53885											
UGT2A1	10941	broad.mit.edu	37	chr4	70460413	70460413	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagctttggttttgggatgTcctaatttgaggatggagtg	9	15	14	3	0	0	1	0	1	0	0	1	4	1	4	1	4	1	2	1	4	2	5			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr4:70460413T>C	uc003hem.3	-	5	1149	c.1086A>G	c.(1084-1086)GGA>GGG	p.G362G	UGT2A1_uc011caq.1_Silent_p.G528G|UGT2A1_uc010ihu.2_Silent_p.G362G|UGT2A1_uc010iht.2_Silent_p.G318G|UGT2A1_uc010ihs.2_Silent_p.G363G	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	362	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						TTTTGGGATGTCCTAATTTGA	0.418													2	8					0	0	0	0	C	70460413	C	C	70460413	2	2	292	1	0	0	0	0	0	0	0	1	17021	1681	58	5		5	UGT2A1	4	70460413	Silent	SNP	T	TCGA-DQ-7592-01A-11D-2078-08	60675352	70460413	120693863	26	53886											
FAT1	2195	broad.mit.edu	37	chr4	187531028	187531029	+	Frame_Shift_Ins	INS	-	T	T																															gtcttggctgaacacaggggINStattatcgttgatatctgtt																										TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr4:187531028_187531029insT	uc003izf.2	-	15	10182_10183	c.9994_9995insA	c.(9994-9996)ACCfs	p.T3332fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3332	Extracellular (Potential).|Cadherin 30.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GAACACAGGGGTATTATCGTTG	0.465										HNSCC(5;0.00058)			---	---	---								T	187531029	T	T	187531028	7	5	292	1	0	1	1	0	0	0	0	0	5721	1261	44	0	3823	0	FAT1	4	187531028	Frame_Shift_Ins	INS	-	TCGA-DQ-7592-01A-11D-2078-08	117070615	187531028	3623248	27	53887											
CMBL	134147	broad.mit.edu	37	chr5	10280584	10280584	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctacatgtacttgttcagcCactcaattaaattccttctg	10	15	5	11	0	3	0	2	0	1	0	4	0	4	0	2	0	3	3	2	0	5	7			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr5:10280584C>T	uc003jes.2	-	6	1170	c.719G>A	c.(718-720)TGG>TAG	p.W240*		NM_138809	NP_620164	Q96DG6	CMBL_HUMAN	carboxymethylenebutenolidase	240						cytosol	hydrolase activity|protein binding			skin(1)	1						CTTGTTCAGCCACTCAATTAA	0.418													7	87					0	0	0	0	T	10280584	T	T	10280584	4	4	292	1	0	0	0	0	0	1	0	0	3591	595	21	4	22	4	CMBL	5	10280584	Nonsense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		10280584	170634676	28	53888											
HCN1	348980	broad.mit.edu	37	chr5	45262631	45262631	+	Frame_Shift_Del	DEL	G	-	-																															tgacaggatggctgatggctGgggggtctgtgtgctgggac																										TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr5:45262631delG	uc003jok.2	-	8	2090	c.2065delC	c.(2065-2067)CAGfs	p.Q689fs		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	689	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GCTGATGGCTGGGGGGTCTGT	0.637													---	---	---								-	45262631	-	-	45262631	7	5	292	1	0	1	0	1	0	0	0	0	7035	1357	47	0	611	0	HCN1	5	45262631	Frame_Shift_Del	DEL	G	TCGA-DQ-7592-01A-11D-2078-08	34982047	45262631	135652629	29	53889											
TRIM36	55521	broad.mit.edu	37	chr5	114462268	114462268	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagctgaattcctccactgcCcattaatgcaaatgctggat	12	11	7	11	0	0	1	0	1	0	0	2	2	2	2	3	1	4	3	3	1	4	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr5:114462268C>T	uc003kqs.2	-	10	2628	c.2119G>A	c.(2119-2121)GGC>AGC	p.G707S	TRIM36_uc011cwc.1_Missense_Mutation_p.G695S|TRIM36_uc003kqt.2_Missense_Mutation_p.G552S	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	707	B30.2/SPRY.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		CCTCCACTGCCCATTAATGCA	0.393													7	14					0	0	0	0	T	114462268	T	T	114462268	3	4	292	1	0	0	0	0	1	0	0	0	16577	623	22	4	71	4	TRIM36	5	114462268	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	69199637	114462268	66452992	30	53890											
TIMD4	91937	broad.mit.edu	37	chr5	156381757	156381757	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccgtcacaacagtctctgaAgtgactggtgctgcaaggaa	11	9	11	10	1	2	2	1	2	1	0	4	3	3	3	1	2	3	2	1	2	4	0			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr5:156381757A>C	uc003lwh.2	-	2	126	c.69T>G	c.(67-69)ACT>ACG	p.T23T	TIMD4_uc010jii.2_Silent_p.T23T	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	23						integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAGTCTCTGAAGTGACTGGTG	0.473													4	8					0	0	0	0	C	156381757	C	C	156381757	2	2	292	1	0	0	0	0	0	0	0	1	15969	59	3	5		5	TIMD4	5	156381757	Silent	SNP	A	TCGA-DQ-7592-01A-11D-2078-08	41919489	156381757	24533503	31	53891											
HIST1H2BN	8341	broad.mit.edu	37	chr6	27806706	27806706	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cattacaacaagcgctcgacCatcacctccagggagatcca	13	6	7	15	2	1	1	1	0	0	1	4	3	3	1	4	1	3	1	4	1	3	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr6:27806706C>T	uc003njv.2	+	1	267	c.267C>T	c.(265-267)ACC>ACT	p.T89T	HIST1H2AK_uc003njs.2_5'Flank|HIST1H2BN_uc003njt.1_RNA|HIST1H2BN_uc003nju.1_Silent_p.T89T	NM_003520	NP_003511	Q99877	H2B1N_HUMAN	histone cluster 1, H2bn	89					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGCGCTCGACCATCACCTCCA	0.637													20	94					0	0	0	0	T	27806706	T	T	27806706	2	4	292	1	0	0	0	0	0	0	0	1	7192	581	21	4		4	HIST1H2BN	6	27806706	Silent	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		27806706	143308361	32	53892											
CLIC5	53405	broad.mit.edu	37	chr6	45882035	45882035	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catccccatccaggaacttgCgccgggaccccttgtcttcc	6	9	8	18	2	1	0	0	0	1	0	4	2	4	2	7	2	2	0	7	2	1	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr6:45882035C>T	uc003oxv.3	-	5	1101	c.995G>A	c.(994-996)CGC>CAC	p.R332H	CLIC5_uc003oxu.3_Missense_Mutation_p.R173H|CLIC5_uc003oxw.2_RNA|CLIC5_uc003oxx.2_Missense_Mutation_p.R173H	NM_001114086	NP_001107558	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5 isoform a	332	GST C-terminal.				female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			ovary(1)|skin(1)	2						CAGGAACTTGCGCCGGGACCC	0.557													13	48					0	0	0	0	T	45882035	T	T	45882035	3	4	292	1	0	0	0	0	1	0	0	0	3544	768	27	1	245	1	CLIC5	6	45882035	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	18075329	45882035	125233032	33	53893											
FBXL4	26235	broad.mit.edu	37	chr6	99353453	99353453	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgaggtggatgtattgcaGaggatcacagcaatgctggc	11	10	14	6	0	1	2	1	1	0	1	1	4	1	4	0	4	3	4	0	4	2	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr6:99353453G>A	uc003ppf.1	-	5	1310	c.952C>T	c.(952-954)CTG>TTG	p.L318L	FBXL4_uc003ppg.1_Silent_p.L318L|FBXL4_uc003pph.1_5'UTR|FBXL4_uc010kcp.2_5'UTR	NM_012160	NP_036292	Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	318	F-box.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				skin(2)	2		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		ATGTATTGCAGAGGATCACAG	0.433													12	42					0	0	0	0	A	99353453	A	A	99353453	2	1	292	1	0	0	0	0	0	0	0	1	5753	933	33	2		2	FBXL4	6	99353453	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	53471418	99353453	71761614	34	53894											
EPB41L2	2037	broad.mit.edu	37	chr6	131222184	131222184	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggaattcactgaggtcgaTgctgccatgttcttctgggt	6	14	12	9	1	3	1	1	1	2	0	4	3	3	2	1	3	2	2	1	3	1	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr6:131222184T>C	uc003qch.2	-	7	1248	c.1066A>G	c.(1066-1068)ATC>GTC	p.I356V	EPB41L2_uc003qcg.1_Missense_Mutation_p.I356V|EPB41L2_uc011eby.1_Missense_Mutation_p.I356V|EPB41L2_uc003qci.2_Missense_Mutation_p.I356V|EPB41L2_uc010kfk.2_Missense_Mutation_p.I356V|EPB41L2_uc010kfl.1_Missense_Mutation_p.I356V	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	356	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CTGAGGTCGATGCTGCCATGT	0.542													19	94					0	0	0	0	C	131222184	C	C	131222184	3	2	292	1	0	0	0	0	1	0	0	0	5177	1464	51	5	2003	5	EPB41L2	6	131222184	Missense_Mutation	SNP	T	TCGA-DQ-7592-01A-11D-2078-08	31868731	131222184	39892883	35	53895											
PEX3	8504	broad.mit.edu	37	chr6	143793311	143793311	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctagtgtttctcttaaacAttctttgtcccttttggact	6	21	5	9	0	3	0	0	0	3	0	5	1	4	1	1	1	1	1	1	1	3	8			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr6:143793311A>G	uc003qjl.2	+	8	855	c.593A>G	c.(592-594)CAT>CGT	p.H198R	PEX3_uc011edx.1_Missense_Mutation_p.H198R	NM_003630	NP_003621	P56589	PEX3_HUMAN	peroxisomal biogenesis factor 3	198	Cytoplasmic (Potential).				protein import into peroxisome membrane|transmembrane transport	integral to peroxisomal membrane	protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.73e-06)|GBM - Glioblastoma multiforme(68;0.0117)		TCTCTTAAACATTCTTTGTCC	0.333													19	20					0	0	0	0	G	143793311	G	G	143793311	3	3	292	1	0	0	0	0	1	0	0	0	11802	217	8	5	623	5	PEX3	6	143793311	Missense_Mutation	SNP	A	TCGA-DQ-7592-01A-11D-2078-08	12571127	143793311	27321756	36	53896											
ESR1	2099	broad.mit.edu	37	chr6	152129337	152129338	+	Frame_Shift_Ins	INS	-	C	C																															tccaacggcctggggggtttINSccccccactcaacagcgtgt																										TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr6:152129337_152129338insC	uc003qom.3	+	3	660_661	c.290_291insC	c.(289-291)TTCfs	p.F97fs	ESR1_uc010kin.2_Frame_Shift_Ins_p.F97fs|ESR1_uc010kio.2_Frame_Shift_Ins_p.F97fs|ESR1_uc010kip.2_Frame_Shift_Ins_p.F97fs|ESR1_uc003qon.3_Frame_Shift_Ins_p.F97fs|ESR1_uc003qoo.3_Frame_Shift_Ins_p.F97fs|ESR1_uc010kiq.2_5'UTR|ESR1_uc010kir.2_Frame_Shift_Ins_p.F97fs	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	97	Modulating; mediates interaction with MACROD1.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	CTGGGGGGTTTCCCCCCACTCA	0.723													---	---	---								C	152129338	C	C	152129337	7	5	292	1	0	1	1	0	0	0	0	0	5280	1783	62	0	292	0	ESR1	6	152129337	Frame_Shift_Ins	INS	-	TCGA-DQ-7592-01A-11D-2078-08	8336026	152129337	18985730	37	53897											
RADIL	55698	broad.mit.edu	37	chr7	4874238	4874238	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gcccaccccagcacactgacCcagacagtctcgcggatcag	10	4	9	18	2	2	2	1	1	1	1	3	3	2	3	4	1	1	1	4	1	0	0			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr7:4874238C>T	uc003snj.1	-	4	1589	c.1416G>A	c.(1414-1416)TGG>TGA	p.W472*	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_5'Flank|RADIL_uc011jwc.1_Nonsense_Mutation_p.W232*|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	472					cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GCACACTGACCCAGACAGTCT	0.682													3	10					0	0	0	0	T	4874238	T	T	4874238	4	4	292	1	0	0	0	0	0	1	0	0	13062	637	22	4	1859	4	RADIL	7	4874238	Nonsense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		4874238	154264425	38	53898											
DNAH11	8701	broad.mit.edu	37	chr7	21934574	21934574	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacacggtaccagacactTggagcaaactggcttatcct	12	9	9	11	1	0	2	0	1	0	1	1	3	1	3	2	3	3	3	2	3	3	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr7:21934574T>G	uc003svc.2	+	80	13058	c.13027T>G	c.(13027-13029)TGG>GGG	p.W4343G		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4343					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ACCAGACACTTGGAGCAAACT	0.522									Kartagener_syndrome				6	41					0	0	0	0	G	21934574	G	G	21934574	3	3	292	1	0	0	0	0	1	0	0	0	4621	1812	63	5	13342	5	DNAH11	7	21934574	Missense_Mutation	SNP	T	TCGA-DQ-7592-01A-11D-2078-08	17060336	21934574	137204089	39	53899											
GPNMB	10457	broad.mit.edu	37	chr7	23306162	23306162	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggtgacaaccccctggagCtgagtaggattcctgatgaa	10	9	12	10	0	0	4	0	4	0	0	1	6	1	6	3	3	2	2	3	3	3	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr7:23306162C>T	uc003swc.2	+	7	1242	c.1081C>T	c.(1081-1083)CTG>TTG	p.L361L	GPNMB_uc003swb.2_Silent_p.L349L|GPNMB_uc011jyy.1_Silent_p.L303L|GPNMB_uc011jyz.1_Silent_p.L250L	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	361	Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			CCCCCTGGAGCTGAGTAGGAT	0.413													9	43					0	0	0	0	T	23306162	T	T	23306162	2	4	292	1	0	0	0	0	0	0	0	1	6658	796	28	4		4	GPNMB	7	23306162	Silent	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	1371588	23306162	135832501	40	53900											
FKBP6	8468	broad.mit.edu	37	chr7	72754700	72754700	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcagcacctggtggaggccGccaagcttcctgttctcctg	6	9	12	14	1	1	0	0	0	1	0	3	1	2	1	5	3	3	4	5	3	1	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr7:72754700G>A	uc003tya.2	+	6	781	c.649G>A	c.(649-651)GCC>ACC	p.A217T	FKBP6_uc003twz.2_Missense_Mutation_p.A187T|FKBP6_uc011kew.1_Missense_Mutation_p.A212T|FKBP6_uc010lbe.1_RNA	NM_003602	NP_003593	O75344	FKBP6_HUMAN	FK506 binding protein 6 isoform a	217					protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				GGTGGAGGCCGCCAAGCTTCC	0.567													13	42					0	0	0	0	A	72754700	A	A	72754700	3	1	292	1	0	0	0	0	1	0	0	0	5944	1087	38	1	717	1	FKBP6	7	72754700	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	49448538	72754700	86383963	41	53901											
C8orf41	80185	broad.mit.edu	37	chr8	33371004	33371004	+	5'Flank	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tataagatgatccttttgtaGttcatgagcgtgatgattgg	10	16	11	4	1	1	5	1	4	0	1	2	5	2	5	1	1	1	2	1	1	3	7			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr8:33371004G>T	uc003xjl.3	-						C8orf41_uc003xjk.3_5'Flank|C8orf41_uc010lvv.2_5'Flank|C8orf41_uc003xjm.3_5'Flank|C8orf41_uc003xjn.1_5'Flank	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185								binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		tccttttgtagttcatgagcg	0.179													7	36					2.17888e-05	2.36564e-05	1	0	T	33371004	T	T	33371004	1	4	292	0	1	0	0	0	0	0	0	0	2439	1044	36	4		4	C8orf41	8	33371004	5'Flank	SNP	G	TCGA-DQ-7592-01A-11D-2078-08		33371004	112993018	42	53902											
DCAF4L2	138009	broad.mit.edu	37	chr8	88885018	88885018	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcatcctgaagaattaaccGtaggagaaacaataaaggtc	17	8	9	7	1	0	3	0	1	0	2	2	4	1	3	2	2	3	2	2	2	8	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr8:88885018G>A	uc003ydz.2	-	1	1279	c.1182C>T	c.(1180-1182)TAC>TAT	p.Y394Y		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	394										ovary(1)	1						AGAATTAACCGTAGGAGAAAC	0.502													19	22					0	0	0	0	A	88885018	A	A	88885018	2	1	292	1	0	0	0	0	0	0	0	1	4289	1140	40	1		1	DCAF4L2	8	88885018	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	55514014	88885018	57479004	43	53903											
LRRC19	64922	broad.mit.edu	37	chr9	26997861	26997861	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caaatagctaatcaaattgcCttgcagattcagaagtttta	15	13	6	7	0	2	2	2	0	0	2	2	2	2	2	1	0	3	3	1	0	6	7			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr9:26997861C>A	uc003zqh.2	-	3	571	c.460G>T	c.(460-462)GGC>TGC	p.G154C	IFT74_uc010mja.2_Intron|IFT74_uc010mjb.2_Intron|IFT74_uc003zqf.3_Intron|IFT74_uc003zqg.3_Intron	NM_022901	NP_075052	Q9H756	LRC19_HUMAN	leucine rich repeat containing 19 precursor	154	LRR 5.|Extracellular (Potential).					integral to membrane					0		all_neural(11;1.81e-09)		Lung(218;1.06e-05)|LUSC - Lung squamous cell carcinoma(38;0.0001)		ATCAAATTGCCTTGCAGATTC	0.323													16	36					4.14922e-12	4.82664e-12	1	0	A	26997861	A	A	26997861	3	1	292	1	0	0	0	0	1	0	0	0	9025	681	24	4	664	4	LRRC19	9	26997861	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		26997861	114215570	44	53904											
TRPM3	80036	broad.mit.edu	37	chr9	73152300	73152300	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctctcgttgacttcctccagCcgcatagacatgttctccac	7	12	6	16	2	2	2	0	1	2	1	6	2	4	2	4	0	1	3	4	0	1	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr9:73152300C>T	uc004aid.2	-	25	3937	c.3693G>A	c.(3691-3693)CGG>CGA	p.R1231R	TRPM3_uc004ahu.2_Silent_p.R1073R|TRPM3_uc004ahv.2_Silent_p.R1033R|TRPM3_uc004ahw.2_Silent_p.R1103R|TRPM3_uc004ahx.2_Silent_p.R1090R|TRPM3_uc004ahy.2_Silent_p.R1093R|TRPM3_uc004ahz.2_Silent_p.R1080R|TRPM3_uc004aia.2_Silent_p.R1078R|TRPM3_uc004aib.2_Silent_p.R1068R|TRPM3_uc004aic.2_Silent_p.R1231R	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1256	Cytoplasmic (Potential).|Potential.					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CTTCCTCCAGCCGCATAGACA	0.572													4	32					0	0	0	0	T	73152300	T	T	73152300	2	4	292	1	0	0	0	0	0	0	0	1	16654	726	26	4		4	TRPM3	9	73152300	Silent	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	46154439	73152300	68061131	45	53905											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112705030	112705030	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggagagaccaagattctctcTacatctaccattggcccaga	12	9	8	12	0	3	3	0	0	3	3	4	5	3	4	3	2	2	0	3	2	3	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr9:112705030T>C	uc004bei.2	+	7	753	c.561T>C	c.(559-561)TCT>TCC	p.S187S	PALM2_uc004bef.2_Silent_p.S189S|PALM2_uc004beg.2_Silent_p.S155S|PALM2_uc004beh.3_Silent_p.S187S|PALM2-AKAP2_uc004bek.3_Intron|PALM2-AKAP2_uc004bej.3_Intron|PALM2-AKAP2_uc004bel.1_Intron	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:Variant_position_missing_in_Q9Y2D5_after_alignment							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AGATTCTCTCTACATCTACCA	0.453													6	21					0	0	0	0	C	112705030	C	C	112705030	2	2	292	1	0	0	0	0	0	0	0	1	11464	1509	53	5		5	PALM2-AKAP2	9	112705030	Silent	SNP	T	TCGA-DQ-7592-01A-11D-2078-08	39552730	112705030	28508401	46	53906											
ASTN2	23245	broad.mit.edu	37	chr9	119976807	119976807	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggagtctcccggatgggcAcgccaatgacggaattgtgg	8	8	16	9	3	1	1	0	1	1	0	2	4	1	4	2	5	0	1	2	5	2	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr9:119976807A>T	uc004bjs.1	-	3	946	c.845T>A	c.(844-846)GTG>GAG	p.V282E	ASTN2_uc004bjr.1_Missense_Mutation_p.V282E|ASTN2_uc004bjt.1_Missense_Mutation_p.V282E	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	282	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CCGGATGGGCACGCCAATGAC	0.602													7	36					0	0	0	0	T	119976807	T	T	119976807	3	4	292	1	0	0	0	0	1	0	0	0	1067	159	6	5	3333	5	ASTN2	9	119976807	Missense_Mutation	SNP	A	TCGA-DQ-7592-01A-11D-2078-08	7271777	119976807	21236624	47	53907											
DOLPP1	57171	broad.mit.edu	37	chr9	131843487	131843487	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccacgtcgaatatcctgcagGtaaaaggcggtcccggctcc	9	7	11	14	4	0	0	0	0	0	0	4	1	3	0	4	4	1	3	4	4	4	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr9:131843487G>C	uc004bxc.2	+	1	104	c.76_splice	c.e1+1	p.G26_splice	DOLPP1_uc004bxd.2_Splice_Site_p.G26_splice|DOLPP1_uc004bxe.2_Splice_Site	NM_020438	NP_065171	Q86YN1	DOPP1_HUMAN	dolichyl pyrophosphate phosphatase 1 isoform a						dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			skin(1)	1						TATCCTGCAGGTAAAAGGCGG	0.706													8	44					0	0	0	0	C	131843487	C	C	131843487	5	2	292	1	0	0	0	0	0	0	1	0	4726	1275	44	4	79	4	DOLPP1	9	131843487	Splice_Site	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	11866680	131843487	9369944	48	53908											
TTF1	7270	broad.mit.edu	37	chr9	135271848	135271850	+	In_Frame_Del	DEL	TCT	-	-																															gtaattgttgacatcgaacaTcttctttgctcgatagtata																										TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr9:135271848_135271850delTCT	uc004cbl.2	-	5	1878_1880	c.1826_1828delAGA	c.(1825-1830)AAGATG>ATG	p.K609del	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_In_Frame_Del_p.K94del	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	609					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ACATCGAACATCTTCTTTGCTCG	0.389													---	---	---								-	135271850	-	-	135271848	7	5	292	1	0	1	0	1	0	0	0	0	16786	1435	50	0	917	0	TTF1	9	135271848	In_Frame_Del	DEL	TCT	TCGA-DQ-7592-01A-11D-2078-08	3428361	135271848	5941583	49	53909											
NDST2	8509	broad.mit.edu	37	chr10	75567374	75567374	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgggaagccgggcccgaCgaagaactggtcctggcact	9	5	15	12	3	0	1	0	0	0	1	1	4	1	2	3	4	2	1	3	4	3	0			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr10:75567374C>T	uc001jvk.2	-	3	1577	c.773G>A	c.(772-774)CGT>CAT	p.R258H	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Missense_Mutation_p.R135H|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_Missense_Mutation_p.R135H	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	258	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					CCGGGCCCGACGAAGAACTGG	0.562													11	27					0	0	0	0	T	75567374	T	T	75567374	3	4	292	1	0	0	0	0	1	0	0	0	10310	536	19	1	1930	1	NDST2	10	75567374	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		75567374	59967373	50	53910											
MYST4	23522	broad.mit.edu	37	chr10	76780360	76780360	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctatttgctttctagaagaGaaggccaagcagggtctcct	10	11	11	9	0	2	2	0	0	2	2	3	3	2	2	2	2	2	3	2	2	5	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr10:76780360G>C	uc001jwn.1	+	14	3143	c.2650G>C	c.(2650-2652)GAA>CAA	p.E884Q	MYST4_uc001jwm.1_Missense_Mutation_p.E592Q|MYST4_uc001jwo.1_Missense_Mutation_p.E592Q|MYST4_uc001jwp.1_Missense_Mutation_p.E701Q	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	884	Catalytic.|Interaction with BRPF1.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					TTCTAGAAGAGAAGGCCAAGC	0.478			T	CREBBP	AML								15	25					0	0	0	0	C	76780360	C	C	76780360	3	2	292	1	0	0	0	0	1	0	0	0	10158	943	33	2	2696	2	MYST4	10	76780360	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	1212986	76780360	58754387	51	53911											
TDRD1	56165	broad.mit.edu	37	chr10	115973760	115973760	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttgggtgtggaaggaaaagTaaatccattggagtggacat	13	10	14	4	0	0	0	0	0	0	0	1	4	1	4	1	5	0	1	1	5	5	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr10:115973760T>C	uc001lbg.1	+	16	2252	c.2099T>C	c.(2098-2100)GTA>GCA	p.V700A	TDRD1_uc001lbf.2_Missense_Mutation_p.V634A|TDRD1_uc001lbh.1_Missense_Mutation_p.V691A|TDRD1_uc001lbi.1_Missense_Mutation_p.V691A|TDRD1_uc010qsc.1_Missense_Mutation_p.V304A|TDRD1_uc001lbj.2_Missense_Mutation_p.V409A	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	700					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		GAAGGAAAAGTAAATCCATTG	0.443													12	39					0	0	0	0	C	115973760	C	C	115973760	3	2	292	1	0	0	0	0	1	0	0	0	15796	1638	57	5	2157	5	TDRD1	10	115973760	Missense_Mutation	SNP	T	TCGA-DQ-7592-01A-11D-2078-08	39193400	115973760	19560987	52	53912											
OR52E4	390081	broad.mit.edu	37	chr11	5905534	5905534	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgggagaatgccttctatCaatgacacccacttctatcc	10	11	7	13	0	3	2	1	1	2	1	4	3	4	2	3	1	1	1	3	1	4	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr11:5905534C>G	uc010qzs.1	+	1	12	c.12C>G	c.(10-12)ATC>ATG	p.I4M	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	4	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCTTCTATCAATGACACCC	0.428													19	77					0	0	0	0	G	5905534	G	G	5905534	3	3	292	1	0	0	0	0	1	0	0	0	11170	816	29	2	14	2	OR52E4	11	5905534	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		5905534	129100982	53	53913											
OR52L1	338751	broad.mit.edu	37	chr11	6008146	6008146	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttggagaggaaagagaaaaaAgaaaccaaagtcatgatttc	20	7	10	4	0	1	4	1	1	0	3	2	7	1	5	1	2	1	0	1	2	6	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr11:6008146A>G	uc001mcd.2	-	1	70	c.15T>C	c.(13-15)TCT>TCC	p.S5S		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAGAGAAAAAAGAAACCAAAG	0.423													4	30					0	0	0	0	G	6008146	G	G	6008146	2	3	292	1	0	0	0	0	0	0	0	1	11179	59	3	5		5	OR52L1	11	6008146	Silent	SNP	A	TCGA-DQ-7592-01A-11D-2078-08	102612	6008146	128998370	54	53914											
PPFIBP2	8495	broad.mit.edu	37	chr11	7670885	7670885	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccggcggccagctgatgaGgtgagaccacaaatagtatc	12	6	12	11	2	0	3	0	3	0	1	1	4	0	3	3	3	1	2	3	3	3	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr11:7670885G>A	uc001mfj.3	+	21	2509	c.2121G>A	c.(2119-2121)GAG>GAA	p.E707E	PPFIBP2_uc010rbb.1_Silent_p.E630E|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_Silent_p.E641E|PPFIBP2_uc010rbe.1_Silent_p.E595E|PPFIBP2_uc001mfl.3_Silent_p.E564E|PPFIBP2_uc009yfj.1_Silent_p.E351E	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	707					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding	p.E707D(1)		ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CAGCTGATGAGGTGAGACCAC	0.498													20	180					0	0	0	0	A	7670885	A	A	7670885	2	1	292	1	0	0	0	0	0	0	0	1	12369	1014	35	4		4	PPFIBP2	11	7670885	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	1662739	7670885	127335631	55	53915											
SPTBN2	6712	broad.mit.edu	37	chr11	66472445	66472445	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcggggctggacaccaggcGcagtgcgtcaaccaaccagg	9	4	14	14	3	1	0	1	0	0	0	2	1	1	1	3	5	3	2	3	5	2	0			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr11:66472445G>A	uc001ojd.2	-	14	2374	c.2302C>T	c.(2302-2304)CGC>TGC	p.R768C		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	768	Spectrin 5.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GACACCAGGCGCAGTGCGTCA	0.682													11	52					0	0	0	0	A	66472445	A	A	66472445	3	1	292	1	0	0	0	0	1	0	0	0	15186	1087	38	1	4966	1	SPTBN2	11	66472445	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	58801560	66472445	68534071	56	53916											
TPCN2	219931	broad.mit.edu	37	chr11	68846464	68846464	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccccagcaacgtgtttgaCgggctcctcaccgttgtcct	6	11	9	15	3	1	1	1	1	0	0	3	1	3	1	5	1	3	4	5	1	2	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr11:68846464C>T	uc001oos.2	+	16	1631	c.1515C>T	c.(1513-1515)GAC>GAT	p.D505D	TPCN2_uc001oor.2_Silent_p.D420D|TPCN2_uc010rqg.1_Silent_p.D505D|TPCN2_uc001oot.2_RNA	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	505	Helical; Name=S3 of repeat II; (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ACGTGTTTGACGGGCTCCTCA	0.612													5	74					0	0	0	0	T	68846464	T	T	68846464	2	4	292	1	0	0	0	0	0	0	0	1	16463	535	19	1		1	TPCN2	11	68846464	Silent	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	2374019	68846464	66160052	57	53917											
CACNA1C	775	broad.mit.edu	37	chr12	2717687	2717687	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctgcaggctgctgtacCgctccatcgactcccacacg	6	8	8	19	3	0	0	0	0	0	0	4	1	3	0	5	1	3	5	5	1	1	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr12:2717687C>T	uc009zdu.1	+	28	3740	c.3427C>T	c.(3427-3429)CGC>TGC	p.R1143C	CACNA1C_uc009zdv.1_Missense_Mutation_p.R1120C|CACNA1C_uc001qkb.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qkc.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qke.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qkf.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qjz.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qkd.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qkg.2_Missense_Mutation_p.R1123C|CACNA1C_uc009zdw.1_Missense_Mutation_p.R1123C|CACNA1C_uc001qkh.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qkl.2_Missense_Mutation_p.R1143C|CACNA1C_uc001qkn.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qko.2_Missense_Mutation_p.R1143C|CACNA1C_uc001qkp.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qkr.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qku.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qkq.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qks.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qkt.2_Missense_Mutation_p.R1123C|CACNA1C_uc001qka.1_Missense_Mutation_p.R658C|CACNA1C_uc001qki.1_Missense_Mutation_p.R859C|CACNA1C_uc001qkj.1_Missense_Mutation_p.R859C|CACNA1C_uc001qkk.1_Missense_Mutation_p.R859C|CACNA1C_uc001qkm.1_Missense_Mutation_p.R859C	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1143	Extracellular (Potential).|III.|Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCTGCTGTACCGCTCCATCGA	0.493													4	16					0	0	0	0	T	2717687	T	T	2717687	3	4	292	1	0	0	0	0	1	0	0	0	2552	652	23	1	3645	1	CACNA1C	12	2717687	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		2717687	131134208	58	53918											
ACRBP	84519	broad.mit.edu	37	chr12	6753666	6753666	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccttgctcctgcttgtgcTctggcgcttgctcctggcct	0	15	10	16	1	1	0	0	0	1	0	4	0	4	0	4	2	4	5	4	2	0	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr12:6753666T>A	uc001qpu.1	-	5	629	c.581A>T	c.(580-582)GAG>GTG	p.E194V	ACRBP_uc010sfg.1_Missense_Mutation_p.E161V	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	194						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						CTGCTTGTGCTCTGGCGCTTG	0.463													9	99					0	0	0	0	A	6753666	A	A	6753666	3	1	292	1	0	0	0	0	1	0	0	0	170	1551	54	5	1074	5	ACRBP	12	6753666	Missense_Mutation	SNP	T	TCGA-DQ-7592-01A-11D-2078-08	4035979	6753666	127098229	59	53919											
PZP	5858	broad.mit.edu	37	chr12	9334673	9334673	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attcgtgcaatgggggcaacGtctgactccacagggaagga	11	7	14	9	2	1	1	0	1	1	0	3	3	2	3	1	4	2	2	1	4	3	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr12:9334673G>A	uc001qvl.2	-	14	1616	c.1587C>T	c.(1585-1587)GAC>GAT	p.D529D	PZP_uc009zgl.2_Silent_p.D398D	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TGGGGGCAACGTCTGACTCCA	0.413													11	37					0	0	0	0	A	9334673	A	A	9334673	2	1	292	1	0	0	0	0	0	0	0	1	12934	1136	40	1		1	PZP	12	9334673	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	2581007	9334673	124517222	60	53920											
PTPRO	5800	broad.mit.edu	37	chr12	15636952	15636952	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtccaagatgataataacatCgttgtctcattagaagcttc	13	13	7	8	1	1	3	1	1	1	2	5	3	2	3	1	0	2	2	1	0	5	5			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr12:15636952C>T	uc001rcv.1	+	2	294	c.120C>T	c.(118-120)ATC>ATT	p.I40I	PTPRO_uc001rcw.1_Silent_p.I40I|PTPRO_uc001rcu.1_Silent_p.I40I	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	40	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				ATAATAACATCGTTGTCTCAT	0.348													22	73					0	0	0	0	T	15636952	T	T	15636952	2	4	292	1	0	0	0	0	0	0	0	1	12874	874	31	1		1	PTPRO	12	15636952	Silent	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	6302279	15636952	118214943	61	53921											
SLC16A7	9194	broad.mit.edu	37	chr12	60169147	60169147	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgggagtgttagcagtgtTctctttgaaactctcatgga	8	16	11	6	0	2	1	1	1	2	0	4	3	2	3	0	2	2	3	0	2	2	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr12:60169147T>G	uc001sqs.2	+	5	1370	c.1071T>G	c.(1069-1071)GTT>GTG	p.V357V	SLC16A7_uc001sqt.2_Silent_p.V357V|SLC16A7_uc001squ.2_Silent_p.V357V|SLC16A7_uc009zqi.2_Silent_p.V258V|SLC16A7_uc010ssi.1_Silent_p.V258V	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	357	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	TTAGCAGTGTTCTCTTTGAAA	0.498													18	70					0	0	0	0	G	60169147	G	G	60169147	2	3	292	1	0	0	0	0	0	0	0	1	14478	1770	62	5		5	SLC16A7	12	60169147	Silent	SNP	T	TCGA-DQ-7592-01A-11D-2078-08	44532195	60169147	73682748	62	53922											
DNAH10	196385	broad.mit.edu	37	chr12	124335520	124335520	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cgcaggccgcacggagctgcCcgagtcggtgaaggcgctgt	6	5	17	13	6	0	1	0	1	0	0	1	3	0	2	2	4	2	4	2	4	1	0			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr12:124335520C>T	uc001uft.3	+	34	5859	c.5834C>T	c.(5833-5835)CCC>CTC	p.P1945L		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1945	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACGGAGCTGCCCGAGTCGGTG	0.612													24	35					0	0	0	0	T	124335520	T	T	124335520	3	4	292	1	0	0	0	0	1	0	0	0	4620	623	22	4	5968	4	DNAH10	12	124335520	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	64166373	124335520	9516375	63	53923											
FLT3	2322	broad.mit.edu	37	chr13	28589748	28589748	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagtgagaagatttcccacaGtaatattccatatgaccaga	16	10	7	8	0	0	4	0	2	0	3	2	5	2	4	3	0	0	1	3	0	5	5			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr13:28589748G>A	uc001urw.2	-	21	2714	c.2632C>T	c.(2632-2634)CTG>TTG	p.L878L	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Silent_p.L837L	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	878	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	ATTTCCCACAGTAATATTCCA	0.542			Mis|O		AML|ALL								21	29					0	0	0	0	A	28589748	A	A	28589748	2	1	292	1	0	0	0	0	0	0	0	1	5974	1020	36	4		4	FLT3	13	28589748	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08		28589748	86580130	64	53924											
SPERT	220082	broad.mit.edu	37	chr13	46287473	46287473	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcctttagaccccatggagCgccccatgtcccaggccgac	7	7	10	17	2	0	1	0	0	0	1	1	3	1	2	7	2	2	0	7	2	1	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr13:46287473C>T	uc001van.1	+	3	393	c.313C>T	c.(313-315)CGC>TGC	p.R105C	SPERT_uc001vao.2_Missense_Mutation_p.R69C	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	105						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CCCCATGGAGCGCCCCATGTC	0.667													26	48					0	0	0	0	T	46287473	T	T	46287473	3	4	292	1	0	0	0	0	1	0	0	0	15105	768	27	1	323	1	SPERT	13	46287473	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	17697725	46287473	68882405	65	53925											
PCDH8	5100	broad.mit.edu	37	chr13	53421570	53421570	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgaccttgcaggtggcagcGcggggcccgggtccgcggtc	4	6	18	13	5	0	1	0	1	0	0	2	1	1	1	3	6	2	2	3	6	0	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr13:53421570G>A	uc001vhi.2	-	1	1205	c.1002C>T	c.(1000-1002)CGC>CGT	p.R334R	PCDH8_uc001vhj.2_Silent_p.R334R	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	334	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		AGGTGGCAGCGCGGGGCCCGG	0.721													8	9					0	0	0	0	A	53421570	A	A	53421570	2	1	292	1	0	0	0	0	0	0	0	1	11571	1074	38	1		1	PCDH8	13	53421570	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	7134097	53421570	61748308	66	53926											
FNTB	2342	broad.mit.edu	37	chr14	65453708	65453708	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctttcacctactattgccctCcatcttcctcccccgtctgg	4	14	4	19	1	3	0	1	0	2	0	6	0	6	0	6	1	2	0	6	1	2	5			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr14:65453708C>T	uc001xia.2	+	1	202	c.37C>T	c.(37-39)CCA>TCA	p.P13S	FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|uc001xib.2_5'Flank	NM_002028	NP_002019	P49356	FNTB_HUMAN	farnesyltransferase, CAAX box, beta	13					protein farnesylation	microtubule associated complex	protein binding|protein farnesyltransferase activity			ovary(1)	1				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CTATTGCCCTCCATCTTCCTC	0.562											OREG0022738	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	34					0	0	0	0	T	65453708	T	T	65453708	3	4	292	1	0	0	0	0	1	0	0	0	6010	855	30	2	39	2	FNTB	14	65453708	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		65453708	41895832	67	53927											
NDN	4692	broad.mit.edu	37	chr15	23931748	23931748	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgttccagacggcgctctctCtggcgccgcggcccttcacg	3	8	12	18	7	3	1	1	0	2	1	5	1	4	1	3	3	0	2	3	3	0	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr15:23931748C>G	uc001ywk.2	-	1	703	c.617G>C	c.(616-618)AGA>ACA	p.R206T		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	206	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		GGCGCTCTCTCTGGCGCCGCG	0.652									Prader-Willi_syndrome				4	39					0	0	0	0	G	23931748	G	G	23931748	3	3	292	1	0	0	0	0	1	0	0	0	10301	913	32	2	352	2	NDN	15	23931748	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		23931748	78599644	68	53928											
OTUD7A	161725	broad.mit.edu	37	chr15	31776457	31776457	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacttccaggcgtcgccccgCggcccaccgcccttctccgc	3	7	9	22	6	1	0	0	0	1	0	4	0	2	0	7	2	1	0	7	2	1	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr15:31776457C>T	uc001zfq.2	-	11	1914	c.1821G>A	c.(1819-1821)CCG>CCA	p.P607P	OTUD7A_uc001zfr.2_Silent_p.P614P	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	607						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CGTCGCCCCGCGGCCCACCGC	0.697													4	13					0	0	0	0	T	31776457	T	T	31776457	2	4	292	1	0	0	0	0	0	0	0	1	11372	755	27	1		1	OTUD7A	15	31776457	Silent	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	7844709	31776457	70754935	69	53929											
SPG11	80208	broad.mit.edu	37	chr15	44944131	44944131	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aatgatgatagctgggctttCcaagacctggaaacaaggta	14	9	11	7	0	0	3	0	2	0	1	1	4	1	4	2	3	2	3	2	3	6	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr15:44944131C>A	uc001ztx.2	-	6	1045	c.1014G>T	c.(1012-1014)TGG>TGT	p.W338C	SPG11_uc010ueh.1_Missense_Mutation_p.W338C|SPG11_uc010uei.1_Missense_Mutation_p.W338C|SPG11_uc001zua.1_Missense_Mutation_p.W338C	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	338	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		GCTGGGCTTTCCAAGACCTGG	0.373													4	24					0.00024832	0.000264565	1	0	A	44944131	A	A	44944131	3	1	292	1	0	0	0	0	1	0	0	0	15107	856	30	2	6457	2	SPG11	15	44944131	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	13167674	44944131	57587261	70	53930											
CREBBP	1387	broad.mit.edu	37	chr16	3801777	3801777	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcacattctcgccctggatCtctgtgaaacacttctcaca	9	12	6	14	1	4	1	2	1	3	0	7	2	4	2	1	1	1	0	1	1	1	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr16:3801777C>G	uc002cvv.2	-	20	3933	c.3729G>C	c.(3727-3729)GAG>GAC	p.E1243D	CREBBP_uc002cvw.2_Missense_Mutation_p.E1205D	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1243	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CGCCCTGGATCTCTGTGAAAC	0.522			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				7	24					0	0	0	0	G	3801777	G	G	3801777	3	3	292	1	0	0	0	0	1	0	0	0	3876	912	32	2	3647	2	CREBBP	16	3801777	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		3801777	86552976	71	53931											
RPGRIP1L	23322	broad.mit.edu	37	chr16	53730126	53730126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaatgttctcatcatgcaaaCgcaaaaatctgtcttccagt	14	12	5	10	1	4	0	2	0	3	0	6	0	5	0	1	0	2	3	1	0	4	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr16:53730126C>T	uc002ehp.2	-	3	231	c.167G>A	c.(166-168)CGT>CAT	p.R56H	RPGRIP1L_uc002eho.3_Missense_Mutation_p.R56H|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.R56H|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.R56H|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.R56H|RPGRIP1L_uc002ehq.1_Missense_Mutation_p.R56H|RPGRIP1L_uc010cby.1_Missense_Mutation_p.R56H	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	56					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				ATCATGCAAACGCAAAAATCT	0.398													61	78					0	0	0	0	T	53730126	T	T	53730126	3	4	292	1	0	0	0	0	1	0	0	0	13615	536	19	1	3880	1	RPGRIP1L	16	53730126	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	49928349	53730126	36624627	72	53932											
GNAO1	2775	broad.mit.edu	37	chr16	56309938	56309938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccctggcagccatcgtccGggccatggacactttgggca	6	8	13	14	2	0	0	0	0	0	0	3	1	2	1	4	4	1	2	4	4	0	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr16:56309938G>A	uc002eit.3	+	3	1154	c.257G>A	c.(256-258)CGG>CAG	p.R86Q	GNAO1_uc002eiu.3_Missense_Mutation_p.R86Q	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	86					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				GCCATCGTCCGGGCCATGGAC	0.517													15	35					0	0	0	0	A	56309938	A	A	56309938	3	1	292	1	0	0	0	0	1	0	0	0	6545	1116	39	1	267	1	GNAO1	16	56309938	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	2579812	56309938	34044815	73	53933											
CNGB1	1258	broad.mit.edu	37	chr16	57953017	57953017	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	actcactggtcagcgggtcaAtgctctggggaaactggtac	9	9	13	10	1	4	0	3	0	1	0	4	1	4	1	0	5	4	2	0	5	3	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr16:57953017A>G	uc002emt.2	-	20	2008	c.1943T>C	c.(1942-1944)ATT>ACT	p.I648T	CNGB1_uc010cdh.2_Missense_Mutation_p.I642T	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	648	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						CAGCGGGTCAATGCTCTGGGG	0.577													17	34					0	0	0	0	G	57953017	G	G	57953017	3	3	292	1	0	0	0	0	1	0	0	0	3615	101	4	5	1868	5	CNGB1	16	57953017	Missense_Mutation	SNP	A	TCGA-DQ-7592-01A-11D-2078-08	1643079	57953017	32401736	74	53934											
CES2	8824	broad.mit.edu	37	chr16	66969411	66969411	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaagccagcgcaccccgcTgactccctgcccagtccaaa	9	4	7	21	2	0	1	0	1	0	0	2	1	2	1	7	0	3	2	7	0	2	0			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr16:66969411T>C	uc002eqr.2	+	1	1065	c.65T>C	c.(64-66)CTG>CCG	p.L22P	CES2_uc002eqq.2_Missense_Mutation_p.L22P|CES2_uc002eqs.2_5'UTR|FAM96B_uc002eqp.2_5'Flank	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	Error:Variant_position_missing_in_O00748_after_alignment					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CGCACCCCGCTGACTCCCTGC	0.667													61	71					0	0	0	0	C	66969411	C	C	66969411	3	2	292	1	0	0	0	0	1	0	0	0	3285	1580	55	5	67	5	CES2	16	66969411	Missense_Mutation	SNP	T	TCGA-DQ-7592-01A-11D-2078-08	9016394	66969411	23385342	75	53935											
FHOD1	29109	broad.mit.edu	37	chr16	67267888	67267888	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagcaggggcagtgggggtGagggagctgggatgtctttc	7	8	21	5	0	1	2	0	1	1	1	2	4	1	4	0	6	2	3	0	6	0	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr16:67267888G>T	uc002esl.2	-	13	1830	c.1718C>A	c.(1717-1719)TCA>TAA	p.S573*	FHOD1_uc010ced.2_Nonsense_Mutation_p.S380*|FHOD1_uc010vjh.1_Nonsense_Mutation_p.S233*	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	573	FH1.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		CAGTGGGGGTGAGGGAGCTGG	0.602													7	53					0.000157383	0.000169261	1	0	T	67267888	T	T	67267888	4	4	292	1	0	0	0	0	0	1	0	0	5914	1294	45	2	1816	2	FHOD1	16	67267888	Nonsense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	298477	67267888	23086865	76	53936											
CD68	968	broad.mit.edu	37	chr17	7483866	7483866	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccatccccacctgcttctctCattcccctatggacacctca	7	11	3	20	0	3	0	2	0	1	0	6	1	5	1	7	1	1	1	7	1	1	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr17:7483866C>T	uc002ghv.2	+	3	841	c.650C>T	c.(649-651)TCA>TTA	p.S217L	CD68_uc002ghu.2_Missense_Mutation_p.S190L	NM_001251	NP_001242	P34810	CD68_HUMAN	CD68 antigen isoform A	217	Extracellular (Potential).					endosome membrane|integral to membrane|lysosomal membrane|membrane fraction|plasma membrane					0						CTGCTTCTCTCATTCCCCTAT	0.577													9	80					0	0	0	0	T	7483866	T	T	7483866	3	4	292	1	0	0	0	0	1	0	0	0	3045	838	29	2	660	2	CD68	17	7483866	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		7483866	73711344	77	53937											
TP53	7157	broad.mit.edu	37	chr17	7577575	7577575	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gcaggaactgttacacatgtAgttgtagtggatggtggtac	10	12	14	5	0	0	0	0	0	0	0	0	2	0	2	0	4	3	6	0	4	5	5			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr17:7577575A>C	uc002gim.2	-	7	900	c.706T>G	c.(706-708)TAC>GAC	p.Y236D	TP53_uc002gig.1_Missense_Mutation_p.Y236D|TP53_uc002gih.2_Missense_Mutation_p.Y236D|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y104D|TP53_uc010cng.1_Missense_Mutation_p.Y104D|TP53_uc002gii.1_Missense_Mutation_p.Y104D|TP53_uc010cnh.1_Missense_Mutation_p.Y236D|TP53_uc010cni.1_Missense_Mutation_p.Y236D|TP53_uc002gij.2_Missense_Mutation_p.Y236D|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y143D|TP53_uc002gio.2_Missense_Mutation_p.Y104D	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	236	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> S (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y236C(46)|p.Y236N(12)|p.Y236*(9)|p.Y236H(9)|p.0?(7)|p.Y236D(6)|p.Y236del(4)|p.Y236S(3)|p.Y236fs*4(2)|p.Y236Y(2)|p.Y236_M237delYM(1)|p.I232_Y236delIHYNY(1)|p.Y236fs*5(1)|p.H233fs*6(1)|p.Y236_M237insXX(1)|p.Y234fs*2(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.N235_Y236delNY(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTACACATGTAGTTGTAGTGG	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	15					0	0	0	0	C	7577575	C	C	7577575	3	2	292	1	0	0	0	0	1	0	0	0	16448	420	15	5	584	5	TP53	17	7577575	Missense_Mutation	SNP	A	TCGA-DQ-7592-01A-11D-2078-08	93709	7577575	73617635	78	53938											
CUEDC1	404093	broad.mit.edu	37	chr17	55957093	55957093	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atcaggttccaaagtcctttCcaagatctaaatcagaggca	14	10	7	10	0	3	2	2	0	1	2	6	2	6	2	3	2	0	2	3	2	4	3			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr17:55957093C>G	uc002ivd.1	-	3	1062	c.343G>C	c.(343-345)GAA>CAA	p.E115Q	CUEDC1_uc002ive.1_Missense_Mutation_p.E115Q	NM_017949	NP_060419	Q9NWM3	CUED1_HUMAN	CUE domain-containing 1	115	Pro-rich.									skin(2)	2						AAAGTCCTTTCCAAGATCTAA	0.343													3	59					0	0	0	0	G	55957093	G	G	55957093	3	3	292	1	0	0	0	0	1	0	0	0	4069	864	30	2	849	2	CUEDC1	17	55957093	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	48379518	55957093	25238117	79	53939											
ROCK1	6093	broad.mit.edu	37	chr18	18629142	18629142	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctctttatcatttcaaattTgctgagaagcttcatagcat	11	17	5	8	0	4	1	3	1	1	1	5	2	4	1	0	0	3	3	0	0	4	6			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr18:18629142T>C	uc002kte.2	-	4	1266	c.325A>G	c.(325-327)AAA>GAA	p.K109E		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	109	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					ATTTCAAATTTGCTGAGAAGC	0.363													12	75					0	0	0	0	C	18629142	C	C	18629142	3	2	292	1	0	0	0	0	1	0	0	0	13582	1821	63	5	3859	5	ROCK1	18	18629142	Missense_Mutation	SNP	T	TCGA-DQ-7592-01A-11D-2078-08		18629142	59448106	80	53940											
UBXN6	80700	broad.mit.edu	37	chr19	4446549	4446549	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaggttgaagaagtcccCaggcagttcgaactgcgagg	10	8	15	8	2	0	3	0	2	0	1	2	5	1	3	2	3	2	3	2	3	3	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr19:4446549C>A	uc002man.1	-	8	964	c.868G>T	c.(868-870)GGG>TGG	p.G290W	UBXN6_uc010dty.1_Missense_Mutation_p.G194W|UBXN6_uc002mam.1_Missense_Mutation_p.G237W	NM_025241	NP_079517	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	290						microtubule organizing center|nucleus	protein binding				0						AAGAAGTCCCCAGGCAGTTCG	0.682													6	25					2.0095e-06	2.2241e-06	1	0	A	4446549	A	A	4446549	3	1	292	1	0	0	0	0	1	0	0	0	16985	594	21	4	473	4	UBXN6	19	4446549	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		4446549	54682434	81	53941											
LONP1	9361	broad.mit.edu	37	chr19	5700888	5700888	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtccaggttctcgttgctgTacttgccccaagggatggac	6	11	13	11	1	1	0	0	0	1	0	3	2	2	2	3	4	3	4	3	4	2	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr19:5700888T>C	uc002mcx.2	-	9	1451	c.1418A>G	c.(1417-1419)TAC>TGC	p.Y473C	LONP1_uc002mcy.2_Missense_Mutation_p.Y409C|LONP1_uc010duh.2_Missense_Mutation_p.Y214C|LONP1_uc010dui.2_Missense_Mutation_p.Y457C|LONP1_uc002mcz.2_Missense_Mutation_p.Y277C	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	473					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						CTCGTTGCTGTACTTGCCCCA	0.607													24	73					0	0	0	0	C	5700888	C	C	5700888	3	2	292	1	0	0	0	0	1	0	0	0	8942	1638	57	5	1501	5	LONP1	19	5700888	Missense_Mutation	SNP	T	TCGA-DQ-7592-01A-11D-2078-08	1254339	5700888	53428095	82	53942											
EXOC3L2	90332	broad.mit.edu	37	chr19	45719340	45719340	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggtgtctcacctgatgtctGggtagtcgcgcaccaacact	7	10	12	12	2	2	1	1	1	2	0	4	1	2	1	2	2	1	2	2	2	2	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr19:45719340G>T	uc002pay.1	-	9	973	c.932C>A	c.(931-933)CCA>CAA	p.P311Q		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	311										ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		CCTGATGTCTGGGTAGTCGCG	0.657													15	35					6.31663e-08	7.20095e-08	1	0	T	45719340	T	T	45719340	3	4	292	1	0	0	0	0	1	0	0	0	5329	1348	47	4	305	4	EXOC3L2	19	45719340	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	40018452	45719340	13409643	83	53943											
CCDC8	83987	broad.mit.edu	37	chr19	46915759	46915759	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagtcgctgaactcgctgtcGctggcgttgctgctgtcgta	5	12	13	11	5	0	1	0	1	0	0	4	1	0	1	0	1	3	7	0	1	3	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr19:46915759G>A	uc002pep.2	-	1	1161	c.309C>T	c.(307-309)AGC>AGT	p.S103S		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	103						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		ACTCGCTGTCGCTGGCGTTGC	0.652													17	122					0	0	0	0	A	46915759	A	A	46915759	2	1	292	1	0	0	0	0	0	0	0	1	2866	1078	38	1		1	CCDC8	19	46915759	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	1196419	46915759	12213224	84	53944											
PNMAL2	57469	broad.mit.edu	37	chr19	46998417	46998417	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aggcgtctcatctgcctcagGaccctcgtgtcctgcgcacg	5	9	11	16	4	3	0	2	0	2	0	6	1	4	1	3	2	2	1	3	2	0	0			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr19:46998417G>A	uc002pes.2	-	1	753	c.306C>T	c.(304-306)GTC>GTT	p.V102V	uc002peu.1_Silent_p.R176R	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	102										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		TCTGCCTCAGGACCCTCGTGT	0.478													27	169					0	0	0	0	A	46998417	A	A	46998417	2	1	292	1	0	0	0	0	0	0	0	1	12213	1161	41	2		2	PNMAL2	19	46998417	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	82658	46998417	12130566	85	53945											
ZNF134	7693	broad.mit.edu	37	chr19	58131571	58131571	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagagtcatcttctgaacaGagcatttctatagcagtgtc	12	12	9	8	0	4	3	1	1	3	2	5	4	4	3	0	0	3	2	0	0	4	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr19:58131571G>A	uc002qpn.2	+	3	183	c.84G>A	c.(82-84)CAG>CAA	p.Q28Q	ZNF134_uc002qpo.2_5'UTR|ZNF211_uc010yhb.1_5'Flank	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	28						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CTTCTGAACAGAGCATTTCTA	0.453													34	49					0	0	0	0	A	58131571	A	A	58131571	2	1	292	1	0	0	0	0	0	0	0	1	17791	933	33	2		2	ZNF134	19	58131571	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	11133154	58131571	997412	86	53946											
RBCK1	10616	broad.mit.edu	37	chr20	398533	398533	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcaacacctccctcaaccCtcaggagctgcagcgggagc	9	4	10	18	2	2	0	2	0	0	0	3	2	3	2	4	2	6	3	4	2	2	0			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr20:398533C>G	uc002wdp.3	+	4	1112	c.419C>G	c.(418-420)CCT>CGT	p.P140R	RBCK1_uc010zpl.1_Missense_Mutation_p.P140R|RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Missense_Mutation_p.P98R|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Missense_Mutation_p.L24V	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	140	Interaction with IRF3.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				TCCCTCAACCCTCAGGAGCTG	0.672													8	24					0	0	0	0	G	398533	G	G	398533	3	3	292	1	0	0	0	0	1	0	0	0	13172	681	24	4	452	4	RBCK1	20	398533	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		398533	62626987	87	53947											
BPI	671	broad.mit.edu	37	chr20	36932638	36932638	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gagagaacatggccaggggcCcttgcaacgcgccgagatgg	10	4	16	11	3	0	2	0	0	0	2	0	5	0	2	3	4	3	1	3	4	2	1			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr20:36932638C>A	uc002xib.2	+	1	87	c.25C>A	c.(25-27)CCT>ACT	p.P9T		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	9					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				GGCCAGGGGCCCTTGCAACGC	0.607													33	73					1.22384e-17	1.43832e-17	1	0	A	36932638	A	A	36932638	3	1	292	1	0	0	0	0	1	0	0	0	1495	623	22	4	27	4	BPI	20	36932638	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08	36534105	36932638	26092882	88	53948											
ZNF831	128611	broad.mit.edu	37	chr20	57769698	57769698	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcggcatctgtgtacttggcGgtgcactttcctggtagcag	5	12	14	10	2	1	0	0	0	1	0	2	0	2	0	1	4	3	5	1	4	2	4			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr20:57769698G>A	uc002yan.2	+	1	3624	c.3624G>A	c.(3622-3624)GCG>GCA	p.A1208A		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1208						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TGTACTTGGCGGTGCACTTTC	0.642													10	18					0	0	0	0	A	57769698	A	A	57769698	2	1	292	1	0	0	0	0	0	0	0	1	18252	1103	39	1		1	ZNF831	20	57769698	Silent	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	20837060	57769698	5255822	89	53949											
C22orf28	51493	broad.mit.edu	37	chr22	32784017	32784017	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattggtctcagtttaatggCtttcttgctgattccagcat	8	17	8	8	0	2	1	1	1	2	0	4	1	3	1	1	2	2	4	1	2	2	6			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr22:32784017C>T	uc003amm.2	-	12	1611	c.1480G>A	c.(1480-1482)GCC>ACC	p.A494T		NM_014306	NP_055121	Q9Y3I0	RTCB_HUMAN	hypothetical protein LOC51493	494					cell-matrix adhesion|substrate adhesion-dependent cell spreading|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|tRNA-splicing ligase complex	ATP binding|metal ion binding|RNA ligase (ATP) activity|vinculin binding				0						AGTTTAATGGCTTTCTTGCTG	0.463													4	23					0	0	0	0	T	32784017	T	T	32784017	3	4	292	1	0	0	0	0	1	0	0	0	2150	797	28	4	41	4	C22orf28	22	32784017	Missense_Mutation	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		32784017	18520549	90	53950											
TCF20	6942	broad.mit.edu	37	chr22	42605941	42605941	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaccacagtcttccgagcGgtggcgccgcttaaacctgg	7	8	11	15	4	1	0	0	0	1	0	3	1	3	0	5	3	2	1	5	3	2	2			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chr22:42605941G>A	uc003bcj.1	-	1	5505	c.5371C>T	c.(5371-5373)CGC>TGC	p.R1791C	TCF20_uc003bck.1_Missense_Mutation_p.R1791C|TCF20_uc003bnt.2_Missense_Mutation_p.R1791C	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1791	Nuclear localization signal (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						TCTTCCGAGCGGTGGCGCCGC	0.597													16	46					0	0	0	0	A	42605941	A	A	42605941	3	1	292	1	0	0	0	0	1	0	0	0	15756	1116	39	1	549	1	TCF20	22	42605941	Missense_Mutation	SNP	G	TCGA-DQ-7592-01A-11D-2078-08	9821924	42605941	8698625	91	53951											
FAM46D	169966	broad.mit.edu	37	chrX	79698533	79698533	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaaaatttgtgagttcactCagacggcagtttgaatttag	12	14	9	6	1	2	3	2	2	0	1	2	3	2	3	0	1	0	3	0	1	4	6			TCGA-DQ-7592-01A-11D-2078-08	TCGA-DQ-7592-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d8e20b3b-2666-4b53-aa85-a5056028df98	e942ac91-d4a1-4025-9126-78eb33c94626	g.chrX:79698533C>T	uc004edl.1	+	5	829	c.495C>T	c.(493-495)CTC>CTT	p.L165L	FAM46D_uc004edm.1_Silent_p.L165L	NM_152630	NP_689843	Q8NEK8	FA46D_HUMAN	hypothetical protein LOC169966	165										lung(2)	2						TGAGTTCACTCAGACGGCAGT	0.368													15	29					0	0	0	0	T	79698533	T	T	79698533	2	4	292	1	0	0	0	0	0	0	0	1	5600	813	29	2		2	FAM46D	23	79698533	Silent	SNP	C	TCGA-DQ-7592-01A-11D-2078-08		79698533	75572027	92	53952											
F5	2153	broad.mit.edu	37	chr1	169511588	169511588	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctggaaggagaaccagtgtCttggctaggaaggtcctccc	9	9	13	10	0	2	1	0	0	2	1	4	4	4	3	3	5	1	1	3	5	4	2			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr1:169511588C>T	uc001ggg.1	-	13	2885	c.2740G>A	c.(2740-2742)GAC>AAC	p.D914N		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	914	2 X 17 AA tandem repeats.|B.|1-2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GAACCAGTGTCTTGGCTAGGA	0.478													26	92					0	0	0	0	T	169511588	T	T	169511588	3	4	293	1	0	0	0	0	1	0	0	0	5373	913	32	2	3986	2	F5	1	169511588	Missense_Mutation	SNP	C	TCGA-DQ-7594-01A-11D-2229-08		169511588	79739033	1	53953											
BIRC6	57448	broad.mit.edu	37	chr2	32820175	32820175	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtattaaagtcacttgaaGaaaaatatgtggctgttatg	15	13	9	4	0	1	2	1	1	0	1	1	2	1	2	0	1	0	3	0	1	8	5			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr2:32820175G>A	uc010ezu.2	+	68	13710	c.13576G>A	c.(13576-13578)GAA>AAA	p.E4526K		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4526					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GTCACTTGAAGAAAAATATGT	0.289													4	12					0	0	0	0	A	32820175	A	A	32820175	3	1	293	1	0	0	0	0	1	0	0	0	1441	943	33	2	13846	2	BIRC6	2	32820175	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		32820175	210379198	2	53954											
MOBKL1B	55233	broad.mit.edu	37	chr2	74399789	74399789	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagattcccacttcctagAgttgcttctgcatgttttaa	8	16	6	11	0	2	2	1	0	1	2	4	2	4	2	2	0	2	4	2	0	2	7			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr2:74399789A>G	uc002skh.3	-	2	299	c.105T>C	c.(103-105)ACT>ACC	p.T35T	MOBKL1B_uc002ski.2_Silent_p.T35T	NM_018221	NP_060691	Q9H8S9	MOL1B_HUMAN	Mob4B protein	35					hippo signaling cascade		metal ion binding|protein binding				0						CACTTCCTAGAGTTGCTTCTG	0.398													17	52					0	0	0	0	G	74399789	G	G	74399789	2	3	293	1	0	0	0	0	0	0	0	1	9736	291	11	5		5	MOBKL1B	2	74399789	Silent	SNP	A	TCGA-DQ-7594-01A-11D-2229-08	41579614	74399789	168799584	3	53955											
TTN	7273	broad.mit.edu	37	chr2	179499108	179499108	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cttacctgtgacaaacaaccGagctgaggtcttcttgccct	9	11	8	13	1	2	2	0	2	2	0	2	3	2	2	3	1	5	1	3	1	3	3			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr2:179499108G>A	uc010zfg.1	-	179	34920	c.34696C>T	c.(34696-34698)CGG>TGG	p.R11566W	TTN_uc010zfh.1_Missense_Mutation_p.R5261W|TTN_uc010zfi.1_Missense_Mutation_p.R5194W|TTN_uc010zfj.1_Missense_Mutation_p.R5069W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12493							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAAACAACCGAGCTGAGGTC	0.408													7	17					0	0	0	0	A	179499108	A	A	179499108	3	1	293	1	0	0	0	0	1	0	0	0	16803	1057	37	1	65825	1	TTN	2	179499108	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	105099319	179499108	63700265	4	53956											
UROC1	131669	broad.mit.edu	37	chr3	126226625	126226625	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcttctcatactccgtccGggaggagtagttgggaatga	9	10	14	8	2	1	1	1	1	1	0	4	5	3	4	2	3	2	3	2	3	3	4	rs34488036	byFrequency	TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr3:126226625G>A	uc003eiz.1	-	6	594	c.562C>T	c.(562-564)CGG>TGG	p.R188W	UROC1_uc010hsi.1_Missense_Mutation_p.R188W	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	188					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		TACTCCGTCCGGGAGGAGTAG	0.542													22	76					0	0	0	0	A	126226625	A	A	126226625	3	1	293	1	0	0	0	0	1	0	0	0	17096	1115	39	1	1712	1	UROC1	3	126226625	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		126226625	71795805	5	53957											
NOP14	8602	broad.mit.edu	37	chr4	2956205	2956205	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atcagctctttccgggacttCggtttctcccgctcctcgcc	3	13	8	17	4	3	0	1	0	2	0	8	1	5	1	4	2	1	3	4	2	0	3			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr4:2956205C>T	uc003ggj.1	-	4	630	c.558G>A	c.(556-558)CCG>CCA	p.P186P	C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_5'Flank|NOP14_uc003ggk.3_Silent_p.P186P|NOP14_uc003ggl.2_Silent_p.P186P|NOP14_uc010icq.1_RNA	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	186					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						TCCGGGACTTCGGTTTCTCCC	0.537													13	53					0	0	0	0	T	2956205	T	T	2956205	2	4	293	1	0	0	0	0	0	0	0	1	10590	871	31	1		1	NOP14	4	2956205	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08		2956205	188198071	6	53958											
KCNIP4	80333	broad.mit.edu	37	chr4	20734306	20734306	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgttttaattcctacctGaaaaaatgtttcaacgtgtt	11	18	5	7	1	2	1	1	1	1	0	3	1	3	1	2	0	2	3	2	0	6	7			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr4:20734306G>A	uc003gqe.2	-	6	673	c.589C>T	c.(589-591)CAG>TAG	p.Q197*	KCNIP4_uc003gqf.1_Nonsense_Mutation_p.Q193*|KCNIP4_uc003gqg.1_Nonsense_Mutation_p.Q152*|KCNIP4_uc003gqh.1_Nonsense_Mutation_p.Q189*|KCNIP4_uc003gqi.1_Nonsense_Mutation_p.Q152*|PACRGL_uc003gpu.2_Intron|PACRGL_uc003gpx.3_Intron|PACRGL_uc003gpw.2_Intron|KCNIP4_uc010iel.2_Nonsense_Mutation_p.Q194*|KCNIP4_uc003gqd.3_Nonsense_Mutation_p.Q177*	NM_147182	NP_671711	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4 isoform 3	214	EF-hand 4.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)				ATTCCTACCTGAAAAAATGTT	0.368													6	21					0	0	0	0	A	20734306	A	A	20734306	4	1	293	1	0	0	0	0	0	1	0	0	8081	1299	45	2	124	2	KCNIP4	4	20734306	Nonsense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	17778101	20734306	170419970	7	53959											
LNX1	84708	broad.mit.edu	37	chr4	54327109	54327109	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggccaagaaacaatagttaGagtaattcttcctttaagtt	15	13	7	6	0	1	2	0	0	1	2	2	2	2	2	2	1	1	3	2	1	7	8			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr4:54327109G>A	uc003hag.3	-	11	2408	c.2152C>T	c.(2152-2154)CTA>TTA	p.L718L	PDGFRA_uc003haa.2_Intron|LNX1_uc003haf.3_Silent_p.L622L|LNX1_uc003hah.3_RNA	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a	718	PDZ 4.					cytoplasm	zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			ACAATAGTTAGAGTAATTCTT	0.358													12	42					0	0	0	0	A	54327109	A	A	54327109	2	1	293	1	0	0	0	0	0	0	0	1	8907	933	33	2		2	LNX1	4	54327109	Silent	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	33592803	54327109	136827167	8	53960											
SLC25A2	83884	broad.mit.edu	37	chr5	140683301	140683302	+	Frame_Shift_Ins	INS	-	T	T																															agcagtcggtgaggcccttgINStacaggtcagggaacgtctg																										TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr5:140683301_140683302insT	uc003ljf.2	-	1	311_312	c.131_132insA	c.(130-132)TACfs	p.Y44fs		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	44	Solcar 1.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TGAGGCCCTTGTACAGGTCAGG	0.604													---	---	---								T	140683302	T	T	140683301	7	5	293	1	0	1	1	0	0	0	0	0	14546	1372	48	0	777	0	SLC25A2	5	140683301	Frame_Shift_Ins	INS	-	TCGA-DQ-7594-01A-11D-2229-08		140683301	40231959	9	53961											
RPP40	10799	broad.mit.edu	37	chr6	5002435	5002435	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgttcatgaccaggtttttCagttcttccgatagtatccc	7	16	8	10	1	3	1	2	1	1	0	5	2	5	1	3	1	0	4	3	1	2	7			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr6:5002435C>G	uc003mwl.2	-	2	203	c.168G>C	c.(166-168)CTG>CTC	p.L56L	uc003mwn.1_5'Flank|RPP40_uc003mwm.2_Silent_p.L56L	NM_006638	NP_006629	O75818	RPP40_HUMAN	ribonuclease P 40kDa subunit	56					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0895)				CCAGGTTTTTCAGTTCTTCCG	0.363													9	31					0	0	0	0	G	5002435	G	G	5002435	2	3	293	1	0	0	0	0	0	0	0	1	13679	813	29	2		2	RPP40	6	5002435	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08		5002435	166112632	10	53962											
BAT2	7916	broad.mit.edu	37	chr6	31600743	31600743	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccaggacgaggcgacaagagGagctggccctctcccaagaa	12	3	13	13	2	1	2	0	0	1	2	2	6	1	4	3	4	1	1	3	4	3	0			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr6:31600743G>A	uc003nvb.3	+	16	4542	c.4293G>A	c.(4291-4293)AGG>AGA	p.R1431R	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Silent_p.R1431R	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1431	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						GCGACAAGAGGAGCTGGCCCT	0.587													5	8					0	0	0	0	A	31600743	A	A	31600743	2	1	293	1	0	0	0	0	0	0	0	1	1321	1165	41	2		2	BAT2	6	31600743	Silent	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	26598308	31600743	139514324	11	53963											
VARS	7407	broad.mit.edu	37	chr6	31759487	31759487	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcacatcatgaagacacctcGgggatttgctgctgacacat	11	9	10	11	1	1	3	1	2	0	1	2	4	1	4	1	2	2	3	1	2	1	1			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr6:31759487G>A	uc003nxe.2	-	8	1423	c.1000C>T	c.(1000-1002)CGA>TGA	p.R334*	VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	334					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	AAGACACCTCGGGGATTTGCT	0.582													21	71					0	0	0	0	A	31759487	A	A	31759487	4	1	293	1	0	0	0	0	0	1	0	0	17191	1124	39	1	2886	1	VARS	6	31759487	Nonsense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	158744	31759487	139355580	12	53964											
LPA	4018	broad.mit.edu	37	chr6	161022029	161022029	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccattctgcatctgagcatCgtgtcaggttgcagtactcc	7	13	9	12	1	3	1	1	1	2	0	6	1	5	1	2	1	4	5	2	1	1	3			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr6:161022029C>A	uc003qtl.2	-	20	3167	c.3047G>T	c.(3046-3048)CGA>CTA	p.R1016L		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3524	Kringle 31.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ATCTGAGCATCGTGTCAGGTT	0.498													8	31					0.00307968	0.00312856	1	0	A	161022029	A	A	161022029	3	1	293	1	0	0	0	0	1	0	0	0	8953	884	31	3	3159	3	LPA	6	161022029	Missense_Mutation	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	129262542	161022029	10093038	13	53965											
KIAA1324L	222223	broad.mit.edu	37	chr7	86556203	86556203	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatcctcccggcagattttGggctctatccacttgtacat	8	13	8	12	1	1	2	0	0	1	2	4	2	4	2	3	2	1	3	3	2	2	5			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr7:86556203G>A	uc011kha.1	-	9	1304	c.1119C>T	c.(1117-1119)CCC>CCT	p.P373P	KIAA1324L_uc003uif.1_Silent_p.P133P|KIAA1324L_uc011kgz.1_Silent_p.P259P|KIAA1324L_uc003uie.2_Silent_p.P206P	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	373	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					GGCAGATTTTGGGCTCTATCC	0.378													18	64					0	0	0	0	A	86556203	A	A	86556203	2	1	293	1	0	0	0	0	0	0	0	1	8263	1335	47	4		4	KIAA1324L	7	86556203	Silent	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		86556203	72582460	14	53966											
TOX	9760	broad.mit.edu	37	chr8	59764239	59764239	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgactggttaatggtagtCagctggccatgtggcatcat	8	13	13	7	0	2	1	2	1	0	0	2	1	2	1	1	4	1	4	1	4	2	2			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr8:59764239C>G	uc003xtw.1	-	4	758	c.537G>C	c.(535-537)CTG>CTC	p.L179L		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	179						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				TAATGGTAGTCAGCTGGCCAT	0.527													16	59					0	0	0	0	G	59764239	G	G	59764239	2	3	293	1	0	0	0	0	0	0	0	1	16444	813	29	2		2	TOX	8	59764239	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08		59764239	86599783	15	53967											
PKHD1L1	93035	broad.mit.edu	37	chr8	110412325	110412325	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagggagaggcctgaagcttGaggtgtggaataatagccgt	11	8	17	5	1	0	3	0	2	0	1	0	6	0	4	2	4	2	1	2	4	4	3			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr8:110412325G>A	uc003yne.2	+	13	1137	c.1033G>A	c.(1033-1035)GAG>AAG	p.E345K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	345	Extracellular (Potential).|IPT/TIG 3.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCTGAAGCTTGAGGTGTGGAA	0.418										HNSCC(38;0.096)			16	53					0	0	0	0	A	110412325	A	A	110412325	3	1	293	1	0	0	0	0	1	0	0	0	12027	1291	45	2	1083	2	PKHD1L1	8	110412325	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	50648086	110412325	35951697	16	53968											
C9orf72	203228	broad.mit.edu	37	chr9	27560286	27560286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccacaggtttgcaagtgtGagctgatggcactgtaagtt	10	11	13	7	0	0	2	0	2	0	0	0	2	0	2	1	2	3	6	1	2	2	3			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr9:27560286G>A	uc003zqq.2	-	6	774	c.677C>T	c.(676-678)TCA>TTA	p.S226L		NM_018325	NP_060795	Q96LT7	CI072_HUMAN	hypothetical protein LOC203228 isoform a	226										ovary(3)|central_nervous_system(1)	4		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		TTGCAAGTGTGAGCTGATGGC	0.323													6	19					0	0	0	0	A	27560286	A	A	27560286	3	1	293	1	0	0	0	0	1	0	0	0	2507	1294	45	2	792	2	C9orf72	9	27560286	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		27560286	113653145	17	53969											
GLE1	2733	broad.mit.edu	37	chr9	131285011	131285011	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccctctcggagatggcatCtgaacaactgaagcggtttg	10	9	12	10	2	2	3	0	2	2	1	3	4	2	3	1	3	4	2	1	3	3	1			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr9:131285011C>T	uc004bvj.2	+	4	611	c.497C>T	c.(496-498)TCT>TTT	p.S166F	GLE1_uc004bvi.2_Missense_Mutation_p.S166F|GLE1_uc010myd.2_Intron	NM_001003722	NP_001003722	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator homolog isoform 1	166	Potential.				poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding				0						GAGATGGCATCTGAACAACTG	0.448													11	38					0	0	0	0	T	131285011	T	T	131285011	3	4	293	1	0	0	0	0	1	0	0	0	6472	913	32	2	511	2	GLE1	9	131285011	Missense_Mutation	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	103724725	131285011	9928420	18	53970											
NET1	10276	broad.mit.edu	37	chr10	5496313	5496313	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaaagaaacaggatccaaGagtccaagacttcctccagc	16	6	7	12	0	1	3	1	0	0	3	5	4	5	4	4	1	2	0	4	1	5	1			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr10:5496313G>C	uc001iia.2	+	9	992	c.854G>C	c.(853-855)AGA>ACA	p.R285T	NET1_uc010qar.1_Missense_Mutation_p.R104T|NET1_uc001iib.2_Missense_Mutation_p.R231T|NET1_uc010qas.1_Missense_Mutation_p.R104T	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	285	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						CAGGATCCAAGAGTCCAAGAC	0.453													8	23					0	0	0	0	C	5496313	C	C	5496313	3	2	293	1	0	0	0	0	1	0	0	0	10392	942	33	2	985	2	NET1	10	5496313	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		5496313	130038434	19	53971											
SFMBT2	57713	broad.mit.edu	37	chr10	7412287	7412287	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agcacttgctcctgtctcttCcaaatattctccccagttaa	9	14	4	14	0	2	0	0	0	2	0	6	0	4	0	4	0	2	3	4	0	3	5			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr10:7412287C>G	uc009xio.1	-	3	242	c.151G>C	c.(151-153)GAA>CAA	p.E51Q	SFMBT2_uc001ijn.1_Missense_Mutation_p.E51Q|SFMBT2_uc010qay.1_Missense_Mutation_p.E51Q|SFMBT2_uc001ijo.1_Missense_Mutation_p.E51Q	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	51	MBT 1.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						CCTGTCTCTTCCAAATATTCT	0.438													13	50					0	0	0	0	G	7412287	G	G	7412287	3	3	293	1	0	0	0	0	1	0	0	0	14223	864	30	2	2609	2	SFMBT2	10	7412287	Missense_Mutation	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	1915974	7412287	128122460	20	53972											
CELF2	10659	broad.mit.edu	37	chr10	11299820	11299820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccggatcctccggggacctGatgggctgagtcgaggtgag	6	7	18	10	3	0	3	0	3	0	0	3	6	2	5	4	5	0	1	4	5	0	0			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr10:11299820G>A	uc001iki.3	+	5	594	c.502G>A	c.(502-504)GAT>AAT	p.D168N	CELF2_uc010qbi.1_5'UTR|CELF2_uc010qbj.1_Missense_Mutation_p.D168N|CELF2_uc001ikk.2_Missense_Mutation_p.D175N|CELF2_uc001ikl.3_Missense_Mutation_p.D175N|CELF2_uc010qbk.1_RNA|CELF2_uc010qbl.1_Missense_Mutation_p.D144N|CELF2_uc010qbm.1_5'UTR|CELF2_uc001iko.3_Missense_Mutation_p.D144N|CELF2_uc001ikp.3_Missense_Mutation_p.D144N|CELF2_uc010qbn.1_Missense_Mutation_p.D152N|CELF2_uc009xiw.1_3'UTR|CELF2_uc010qbo.1_Missense_Mutation_p.D57N|CELF2_uc010qbp.1_5'UTR	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	168	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.|RRM 2.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						CCGGGGACCTGATGGGCTGAG	0.512													12	42					0	0	0	0	A	11299820	A	A	11299820	3	1	293	1	0	0	0	0	1	0	0	0	3231	1290	45	2	598	2	CELF2	10	11299820	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	3887533	11299820	124234927	21	53973											
LGI1	9211	broad.mit.edu	37	chr10	95557087	95557087	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagaacgcctcatttaattCtgtctagtagttcccagcgt	9	14	7	11	2	4	1	2	0	2	1	5	1	5	1	2	0	2	2	2	0	4	6			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr10:95557087C>G	uc001kjc.3	+	8	1537	c.1201C>G	c.(1201-1203)CTG>GTG	p.L401V	LGI1_uc010qnv.1_Missense_Mutation_p.L353V|LGI1_uc001kjd.3_Intron|LGI1_uc009xui.2_RNA|LGI1_uc001kje.2_Intron	NM_005097	NP_005088	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1 precursor	401	EAR 4.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4		Colorectal(252;0.124)				TCATTTAATTCTGTCTAGTAG	0.428													9	35					0	0	0	0	G	95557087	G	G	95557087	3	3	293	1	0	0	0	0	1	0	0	0	8792	912	32	2	1231	2	LGI1	10	95557087	Missense_Mutation	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	84257267	95557087	39977660	22	53974											
SPTBN2	6712	broad.mit.edu	37	chr11	66456268	66456268	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagtggctcctggctgcaGagccaggcctctgccatccc	6	7	11	17	0	1	1	0	0	1	1	3	1	3	1	6	3	3	3	6	3	0	0			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr11:66456268G>A	uc001ojd.2	-	30	6159	c.6087C>T	c.(6085-6087)CTC>CTT	p.L2029L	SPTBN2_uc001ojc.1_5'Flank	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	2029	Spectrin 17.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCTGGCTGCAGAGCCAGGCCT	0.607													7	18					0	0	0	0	A	66456268	A	A	66456268	2	1	293	1	0	0	0	0	0	0	0	1	15186	929	33	2		2	SPTBN2	11	66456268	Silent	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		66456268	68550248	23	53975											
KRT75	9119	broad.mit.edu	37	chr12	52818394	52818394	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccccggttgctggtggcactGaatccagaacctcccaggcc	7	7	11	16	1	0	2	0	1	0	1	2	2	2	2	6	4	2	3	6	4	2	1			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr12:52818394G>A	uc001saj.2	-	9	1585	c.1563C>T	c.(1561-1563)TTC>TTT	p.F521F		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	521	Tail.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		TGGTGGCACTGAATCCAGAAC	0.612													41	162					0	0	0	0	A	52818394	A	A	52818394	2	1	293	1	0	0	0	0	0	0	0	1	8527	1281	45	2		2	KRT75	12	52818394	Silent	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		52818394	81033501	24	53976											
ZC3H13	23091	broad.mit.edu	37	chr13	46619638	46619638	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaccttccttctaatttttGacattttgtactacttcaac	9	19	3	10	0	2	2	1	2	1	0	3	2	3	2	2	0	3	1	2	0	4	10			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr13:46619638G>C	uc010tfw.1	-	1	11	c.5C>G	c.(4-6)TCA>TGA	p.S2*	ZC3H13_uc001vas.1_Nonsense_Mutation_p.S2*|ZC3H13_uc001vat.1_Nonsense_Mutation_p.S2*	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	2							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCTAATTTTTGACATTTTGTA	0.383													18	53					0	0	0	0	C	46619638	C	C	46619638	4	2	293	1	0	0	0	0	0	1	0	0	17632	1294	45	2	4753	2	ZC3H13	13	46619638	Nonsense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		46619638	68550240	25	53977											
RB1	5925	broad.mit.edu	37	chr13	48947540	48947540	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcctatttttatcccctctaGgactgttatgaacactatcc	9	16	4	12	0	1	1	0	1	1	0	4	2	4	2	4	1	1	1	4	1	6	7			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr13:48947540G>A	uc001vcb.2	+	12	1294	c.1128_splice	c.e12-1	p.R376_splice	RB1_uc010act.1_Splice_Site_p.R77_splice	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATCCCCTCTAGGACTGTTATG	0.299		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			17	63					0	0	0	0	A	48947540	A	A	48947540	5	1	293	1	0	0	0	0	0	0	1	0	13163	1014	35	4	1173	4	RB1	13	48947540	Splice_Site	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	2327902	48947540	66222338	26	53978											
DACT1	51339	broad.mit.edu	37	chr14	59113462	59113462	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtggggctgtaccccgcGcctgtgcctctgccctacgc	4	9	12	16	3	1	0	0	0	1	0	1	0	1	0	5	2	4	2	5	2	3	2			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr14:59113462G>A	uc001xdw.2	+	4	2285	c.2121G>A	c.(2119-2121)GCG>GCA	p.A707A	DACT1_uc010trv.1_Silent_p.A426A|DACT1_uc001xdx.2_Silent_p.A670A|DACT1_uc010trw.1_Silent_p.A426A	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	707					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						TGTACCCCGCGCCTGTGCCTC	0.677													13	42					0	0	0	0	A	59113462	A	A	59113462	2	1	293	1	0	0	0	0	0	0	0	1	4239	1074	38	1		1	DACT1	14	59113462	Silent	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		59113462	48236078	27	53979											
SYT16	83851	broad.mit.edu	37	chr14	62547863	62547863	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctgcctgtgctgtccgcttCcgcctgtacgctgcccggaa	3	10	12	16	4	0	0	0	0	0	0	2	1	2	1	5	1	4	5	5	1	2	2			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr14:62547863C>T	uc001xfu.1	+	4	1502	c.1305C>T	c.(1303-1305)TTC>TTT	p.F435F	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_5'UTR	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	435	C2 1.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		CTGTCCGCTTCCGCCTGTACG	0.567													7	26					0	0	0	0	T	62547863	T	T	62547863	2	4	293	1	0	0	0	0	0	0	0	1	15538	854	30	2		2	SYT16	14	62547863	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	3434401	62547863	44801677	28	53980											
DLK1	8788	broad.mit.edu	37	chr14	101200717	101200717	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agccgcccggtgaccaactgCgccagcagcccgtgccagaa	9	3	12	17	4	0	2	0	1	0	1	0	2	0	2	6	1	6	1	6	1	2	0			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr14:101200717C>T	uc001yhs.3	+	5	789	c.636C>T	c.(634-636)TGC>TGT	p.C212C	DLK1_uc001yhu.3_Silent_p.C212C	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	212	Extracellular (Potential).|EGF-like 6.				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				TGACCAACTGCGCCAGCAGCC	0.657													12	38					0	0	0	0	T	101200717	T	T	101200717	2	4	293	1	0	0	0	0	0	0	0	1	4586	776	27	1		1	DLK1	14	101200717	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	38652854	101200717	6148823	29	53981											
FRMD5	84978	broad.mit.edu	37	chr15	44166084	44166084	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggaggagtcatgccttctCaggtgtcaatgagcaggctc	8	10	14	9	0	3	1	3	1	1	0	5	3	3	3	1	4	2	2	1	4	1	1			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr15:44166084C>T	uc001ztl.2	-	14	1889	c.1712G>A	c.(1711-1713)TGA>TAA	p.*571*	FRMD5_uc001ztj.1_3'UTR|FRMD5_uc001ztk.1_3'UTR|FRMD5_uc010uef.1_Silent_p.*244*|FRMD5_uc001ztm.2_Silent_p.*244*|FRMD5_uc001ztn.2_Silent_p.*337*	NM_032892	NP_116281	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5 isoform 2	571						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		CATGCCTTCTCAGGTGTCAAT	0.532													9	14					0	0	0	0	T	44166084	T	T	44166084	2	4	293	1	0	0	0	0	0	0	0	1	6087	837	29	2		2	FRMD5	15	44166084	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08		44166084	58365308	30	53982											
B2M	567	broad.mit.edu	37	chr15	45003747	45003747	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagcattcgggccgagatGtctcgctccgtggccttagc	6	9	13	13	4	1	1	0	0	1	1	4	3	2	1	3	2	2	2	3	2	1	2			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr15:45003747G>A	uc001zuc.2	+	1	63	c.3G>A	c.(1-3)ATG>ATA	p.M1I	B2M_uc010uek.1_Missense_Mutation_p.M1I|B2M_uc010bdx.1_Missense_Mutation_p.M1I	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	1					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.M1V(2)		ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GGGCCGAGATGTCTCGCTCCG	0.612													30	42					0	0	0	0	A	45003747	A	A	45003747	3	1	293	1	0	0	0	0	1	0	0	0	1246	1377	48	4	5	4	B2M	15	45003747	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	837663	45003747	57527645	31	53983											
MYO9A	4649	broad.mit.edu	37	chr15	72208801	72208801	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcttgtagtgtcagtcttgtCaggtgctttaaagaatttac	9	17	9	6	0	4	1	2	0	2	1	4	1	4	1	0	1	2	2	0	1	5	7			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr15:72208801C>G	uc002atl.3	-	19	3068	c.2595G>C	c.(2593-2595)CTG>CTC	p.L865L	MYO9A_uc010biq.2_Silent_p.L485L|MYO9A_uc002atn.1_Silent_p.L846L	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	865					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TCAGTCTTGTCAGGTGCTTTA	0.358													12	9					0	0	0	0	G	72208801	G	G	72208801	2	3	293	1	0	0	0	0	0	0	0	1	10137	813	29	2		2	MYO9A	15	72208801	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	27205054	72208801	30322591	32	53984											
MESDC1	59274	broad.mit.edu	37	chr15	81294798	81294798	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggcgcggcccgtgctcttCgagggccccgcctcctctgg	2	7	15	17	5	2	0	0	0	2	0	4	2	3	0	5	4	1	1	5	4	0	1			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr15:81294798C>T	uc002bfz.2	+	1	1504	c.186C>T	c.(184-186)TTC>TTT	p.F62F		NM_022566	NP_072088	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	62											0						CCGTGCTCTTCGAGGGCCCCG	0.687													15	11					0	0	0	0	T	81294798	T	T	81294798	2	4	293	1	0	0	0	0	0	0	0	1	9533	883	31	1		1	MESDC1	15	81294798	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	9085997	81294798	21236594	33	53985											
GEMIN4	50628	broad.mit.edu	37	chr17	650962	650962	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgaagaggatggtgtggttGatggtggggatcatgttgcc	7	12	18	4	1	1	2	1	1	0	1	2	5	1	4	1	6	1	2	1	6	1	2			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr17:650962G>C	uc002frs.1	-	2	440	c.321C>G	c.(319-321)ATC>ATG	p.I107M	GEMIN4_uc010vqa.1_Missense_Mutation_p.I107M	NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	107					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		TGGTGTGGTTGATGGTGGGGA	0.592													7	17					0	0	0	0	C	650962	C	C	650962	3	2	293	1	0	0	0	0	1	0	0	0	6367	1280	45	2	2859	2	GEMIN4	17	650962	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		650962	80544248	34	53986											
ZNF594	84622	broad.mit.edu	37	chr17	5086741	5086741	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgaacatctgtccacagtCataacattcatagggtttct	12	13	6	10	0	4	1	2	1	2	0	5	1	5	1	1	1	2	1	1	1	3	4			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr17:5086741C>G	uc010cla.1	-	2	967	c.811G>C	c.(811-813)GAC>CAC	p.D271H		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	271	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TGTCCACAGTCATAACATTCA	0.393													19	69					0	0	0	0	G	5086741	G	G	5086741	3	3	293	1	0	0	0	0	1	0	0	0	18091	826	29	2	1616	2	ZNF594	17	5086741	Missense_Mutation	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	4435779	5086741	76108469	35	53987											
COX10	1352	broad.mit.edu	37	chr17	14110529	14110529	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcagggccccctcccagctGagagcactgggacgcccacc	7	3	12	19	2	0	1	0	1	0	1	1	3	1	2	5	2	2	3	5	2	0	0			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr17:14110529G>A	uc002gof.3	+	7	1535	c.1331G>A	c.(1330-1332)TGA>TAA	p.*444*	COX10_uc010vvs.1_Silent_p.*227*|COX10_uc010vvt.1_Silent_p.*252*	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	444					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		CCTCCCAGCTGAGAGCACTGG	0.622													5	13					0	0	0	0	A	14110529	A	A	14110529	2	1	293	1	0	0	0	0	0	0	0	1	3777	1285	45	2		2	COX10	17	14110529	Silent	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	9023788	14110529	67084681	36	53988											
ZNF750	79755	broad.mit.edu	37	chr17	80790328	80790328	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccgctctttgaggagactCattttcctccttatgccttg	5	17	7	12	1	2	2	1	1	1	1	5	3	5	2	4	1	1	1	4	1	1	6			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr17:80790328C>T	uc002kga.2	-	2	314	c.3G>A	c.(1-3)ATG>ATA	p.M1I	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	1						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGAGGAGACTCATTTTCCTCC	0.512													4	8					0	0	0	0	T	80790328	T	T	80790328	3	4	293	1	0	0	0	0	1	0	0	0	18199	826	29	2	2176	2	ZNF750	17	80790328	Missense_Mutation	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	66679799	80790328	404882	37	53989											
DTNA	1837	broad.mit.edu	37	chr18	32400877	32400877	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccactcaacttggctcacatCgtgtgagtatccctaccctc	8	11	6	16	1	2	1	2	1	0	0	5	1	3	1	3	1	2	2	3	1	3	3	rs61737438	byFrequency	TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr18:32400877C>T	uc010dmn.1	+	8	1000	c.999C>T	c.(997-999)ATC>ATT	p.I333I	DTNA_uc002kxu.2_Silent_p.I333I|DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Silent_p.I333I|DTNA_uc002kxw.2_Silent_p.I333I|DTNA_uc002kxx.2_Silent_p.I333I|DTNA_uc010dmj.2_Silent_p.I333I|DTNA_uc002kxz.2_Silent_p.I333I|DTNA_uc002kxy.2_Silent_p.I333I|DTNA_uc010dmk.1_RNA|DTNA_uc010dml.2_Silent_p.I333I|DTNA_uc002kyb.3_Silent_p.I333I|DTNA_uc010dmm.2_Silent_p.I333I|DTNA_uc010xby.1_Silent_p.I83I|DTNA_uc010dmo.2_Silent_p.I15I|DTNA_uc002kyd.3_Silent_p.I15I|DTNA_uc010xbz.1_Silent_p.I15I|DTNA_uc010xca.1_Silent_p.I15I|DTNA_uc002kye.2_Silent_p.I15I	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	333					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						TGGCTCACATCGTGTGAGTAT	0.493													12	41					0	0	0	0	T	32400877	T	T	32400877	2	4	293	1	0	0	0	0	0	0	0	1	4810	874	31	1		1	DTNA	18	32400877	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08		32400877	45676371	38	53990											
NOTCH3	4854	broad.mit.edu	37	chr19	15299893	15299893	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acactcgttgacatcggtctCacagcgaggtccagtgtagc	9	9	11	12	3	1	1	1	1	1	0	5	2	2	1	1	2	2	2	1	2	1	2			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr19:15299893C>G	uc002nan.2	-	8	1361	c.1285G>C	c.(1285-1287)GAG>CAG	p.E429Q	NOTCH3_uc002nao.1_Missense_Mutation_p.E429Q	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	429	Extracellular (Potential).|EGF-like 10; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			ACATCGGTCTCACAGCGAGGT	0.642													17	65					0	0	0	0	G	15299893	G	G	15299893	3	3	293	1	0	0	0	0	1	0	0	0	10604	835	29	2	5784	2	NOTCH3	19	15299893	Missense_Mutation	SNP	C	TCGA-DQ-7594-01A-11D-2229-08		15299893	43829090	39	53991											
PPP2R1A	5518	broad.mit.edu	37	chr19	52725391	52725391	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggcaggacatcaccaccaagCacatgctacccacggttctg	11	6	9	15	1	2	0	1	0	1	0	2	1	2	1	3	3	3	4	3	3	2	2			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr19:52725391C>T	uc002pyp.2	+	13	1717	c.1558C>T	c.(1558-1560)CAC>TAC	p.H520Y	PPP2R1A_uc010ydk.1_Missense_Mutation_p.H465Y|PPP2R1A_uc002pyq.2_Missense_Mutation_p.H341Y	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	520	PP2A subunit C binding.|HEAT 14.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CACCACCAAGCACATGCTACC	0.582			Mis		clear cell ovarian carcinoma								8	24					0	0	0	0	T	52725391	T	T	52725391	3	4	293	1	0	0	0	0	1	0	0	0	12442	710	25	4	1608	4	PPP2R1A	19	52725391	Missense_Mutation	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	37425498	52725391	6403592	40	53992											
NLRP13	126204	broad.mit.edu	37	chr19	56423159	56423159	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacagtgctttaggcaaaatGaagaagcttggagttcttcg	12	12	11	6	1	1	2	0	1	1	1	2	3	1	3	0	2	3	4	0	2	6	6			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr19:56423159G>A	uc010ygg.1	-	5	2049	c.2024C>T	c.(2023-2025)TCA>TTA	p.S675L		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	675							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TAGGCAAAATGAAGAAGCTTG	0.403													14	49					0	0	0	0	A	56423159	A	A	56423159	3	1	293	1	0	0	0	0	1	0	0	0	10529	1294	45	2	1133	2	NLRP13	19	56423159	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	3697768	56423159	2705824	41	53993											
ZFP28	140612	broad.mit.edu	37	chr19	57066551	57066551	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	accttcatccaaattggacaCcttaatcaacataagagagt	16	10	5	10	0	2	1	2	0	0	1	3	3	3	2	3	1	1	0	3	1	4	4			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr19:57066551C>T	uc002qnj.2	+	8	2468	c.2397C>T	c.(2395-2397)CAC>CAT	p.H799H	uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	799	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		AAATTGGACACCTTAATCAAC	0.373													26	43					0	0	0	0	T	57066551	T	T	57066551	2	4	293	1	0	0	0	0	0	0	0	1	17709	506	18	4		4	ZFP28	19	57066551	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	643392	57066551	2062432	42	53994											
PLCB4	5332	broad.mit.edu	37	chr20	9376208	9376208	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagcatgatggaagctggaGaatctgcctccccagcaaac	13	6	11	11	0	1	2	0	1	1	1	2	5	2	3	3	2	5	3	3	2	4	0			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr20:9376208G>A	uc002wnf.2	+	18	1589	c.1453G>A	c.(1453-1455)GAA>AAA	p.E485K	PLCB4_uc010gbw.1_Missense_Mutation_p.E485K|PLCB4_uc010gbx.2_Missense_Mutation_p.E485K|PLCB4_uc002wne.2_Missense_Mutation_p.E485K|PLCB4_uc002wnh.2_Missense_Mutation_p.E332K	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	485					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						GGAAGCTGGAGAATCTGCCTC	0.423													6	21					0	0	0	0	A	9376208	A	A	9376208	3	1	293	1	0	0	0	0	1	0	0	0	12085	943	33	2	1515	2	PLCB4	20	9376208	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08		9376208	53649312	43	53995											
GATA5	140628	broad.mit.edu	37	chr20	61048612	61048612	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cactcacgaccctcacccggGaactcctccaagaagtcgga	11	5	8	17	3	2	1	2	0	0	1	5	4	4	3	4	2	1	0	4	2	3	0			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chr20:61048612G>A	uc002ycx.1	-	3	608	c.546C>T	c.(544-546)TTC>TTT	p.F182F		NM_080473	NP_536721	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	182					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding				0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			CCTCACCCGGGAACTCCTCCA	0.697													3	6					0	0	0	0	A	61048612	A	A	61048612	2	1	293	1	0	0	0	0	0	0	0	1	6292	1165	41	2		2	GATA5	20	61048612	Silent	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	51672404	61048612	1976908	44	53996											
CNKSR2	22866	broad.mit.edu	37	chrX	21550065	21550065	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaatcaccaaattcatttCtggatcaggaatatcgaaag	15	11	7	8	1	4	1	3	1	1	0	5	4	4	3	1	2	0	0	1	2	5	3			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chrX:21550065C>T	uc004czx.1	+	11	1219	c.1183C>T	c.(1183-1185)CTG>TTG	p.L395L	CNKSR2_uc004czw.2_Silent_p.L395L|CNKSR2_uc011mjn.1_Silent_p.L346L|CNKSR2_uc011mjo.1_Silent_p.L395L|CNKSR2_uc004czy.2_Silent_p.L17L	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	395	DUF1170.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						AAATTCATTTCTGGATCAGGA	0.378													15	34					0	0	0	0	T	21550065	T	T	21550065	2	4	293	1	0	0	0	0	0	0	0	1	3622	912	32	2		2	CNKSR2	23	21550065	Silent	SNP	C	TCGA-DQ-7594-01A-11D-2229-08		21550065	133720495	45	53997											
ALAS2	212	broad.mit.edu	37	chrX	55047576	55047576	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctttgaggccacagatgcctCagagaaatgttgggcaaagg	12	8	13	8	0	1	3	1	1	0	2	1	4	1	3	2	3	1	2	2	3	2	2			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chrX:55047576C>G	uc004dua.3	-	5	685	c.547G>C	c.(547-549)GAG>CAG	p.E183Q	ALAS2_uc004dub.3_Missense_Mutation_p.E170Q|ALAS2_uc004dud.3_Missense_Mutation_p.E146Q	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	183					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	ACAGATGCCTCAGAGAAATGT	0.512													10	25					0	0	0	0	G	55047576	G	G	55047576	3	3	293	1	0	0	0	0	1	0	0	0	485	835	29	2	1244	2	ALAS2	23	55047576	Missense_Mutation	SNP	C	TCGA-DQ-7594-01A-11D-2229-08	33497511	55047576	100222984	46	53998											
OCRL	4952	broad.mit.edu	37	chrX	128709136	128709136	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggtgaaggttgtggatgaacGaaggtaccggaaagtctttg	11	10	16	4	2	1	2	0	2	1	0	1	5	1	4	1	5	2	2	1	5	5	3			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chrX:128709136G>A	uc004euq.2	+	16	1787	c.1622G>A	c.(1621-1623)CGA>CAA	p.R541Q	OCRL_uc004eur.2_Missense_Mutation_p.R541Q	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	541					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						GTGGATGAACGAAGGTACCGG	0.408													6	20					0	0	0	0	A	128709136	A	A	128709136	3	1	293	1	0	0	0	0	1	0	0	0	10877	1058	37	1	1684	1	OCRL	23	128709136	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	73661560	128709136	26561424	47	53999											
IDH3G	3421	broad.mit.edu	37	chrX	153053583	153053583	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggcaggttatggttggtttcGatgttgcctacaaaacacaa	11	12	11	7	1	0	0	0	0	0	0	1	1	0	0	1	4	3	5	1	4	5	5			TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chrX:153053583G>C	uc004fip.2	-	6	540	c.354C>G	c.(352-354)ATC>ATG	p.I118M	IDH3G_uc004fio.2_Missense_Mutation_p.I60M|IDH3G_uc004fiq.2_Missense_Mutation_p.I118M|IDH3G_uc010num.2_Missense_Mutation_p.I60M|IDH3G_uc004fir.2_Missense_Mutation_p.I60M|IDH3G_uc004fit.1_Missense_Mutation_p.I118M|IDH3G_uc004fis.2_Missense_Mutation_p.I60M|IDH3G_uc004fiu.2_5'Flank	NM_004135	NP_004126	P51553	IDH3G_HUMAN	isocitrate dehydrogenase 3 (NAD+) gamma isoform	118					carbohydrate metabolic process|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleolus	ATP binding|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	GGTTGGTTTCGATGTTGCCTA	0.597													48	164					0	0	0	0	C	153053583	C	C	153053583	3	2	293	1	0	0	0	0	1	0	0	0	7537	1048	37	3	922	3	IDH3G	23	153053583	Missense_Mutation	SNP	G	TCGA-DQ-7594-01A-11D-2229-08	24344447	153053583	2216977	48	54000											
HCFC1	3054	broad.mit.edu	37	chrX	153219875	153219877	+	In_Frame_Del	DEL	GTG	-	-																															gtgtgggtggtgcccgtctcGtgggtctcgcatggcgggtt																										TCGA-DQ-7594-01A-11D-2229-08	TCGA-DQ-7594-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	92e689c0-08ab-472b-aedc-6344fedcbbc0	2e374774-88d9-47db-8beb-ac153d352653	g.chrX:153219875_153219877delGTG	uc004fjp.2	-	17	4501_4503	c.3973_3975delCAC	c.(3973-3975)CACdel	p.H1325del		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1325	HCF repeat 6.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGCCCGTCTCGTGGGTCTCGCAT	0.685													---	---	---								-	153219877	-	-	153219875	7	5	293	1	0	1	0	1	0	0	0	0	7030	1136	40	0	2172	0	HCFC1	23	153219875	In_Frame_Del	DEL	GTG	TCGA-DQ-7594-01A-11D-2229-08	166292	153219875	2050685	49	54001											
VPS13D	55187	broad.mit.edu	37	chr1	12443077	12443077	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtttgatggagctgaagttGttcttggtcctgacacttcc	6	16	11	8	0	1	3	0	3	1	0	3	4	3	4	2	2	1	4	2	2	1	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:12443077G>T	uc001atv.2	+	58	11374	c.11233G>T	c.(11233-11235)GTT>TTT	p.V3745F	VPS13D_uc001atw.2_Missense_Mutation_p.V3720F|VPS13D_uc001atx.2_Missense_Mutation_p.V2932F|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3744					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGCTGAAGTTGTTCTTGGTCC	0.423													39	138					2.00842e-17	2.74052e-17	1	0	T	12443077	T	T	12443077	3	4	294	1	0	0	0	0	1	0	0	0	17260	1377	48	4	11459	4	VPS13D	1	12443077	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08		12443077	236807544	1	54002											
EIF4G3	8672	broad.mit.edu	37	chr1	21268711	21268711	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaagctctgctatggatacTattgcagtagtttcagatgt	10	14	11	6	0	2	1	1	0	1	1	2	3	2	3	0	2	4	5	0	2	5	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:21268711T>C	uc001bec.2	-	9	1024	c.768A>G	c.(766-768)ATA>ATG	p.I256M	EIF4G3_uc010odi.1_Translation_Start_Site|EIF4G3_uc010odj.1_Missense_Mutation_p.I255M|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Missense_Mutation_p.I256M|EIF4G3_uc001bef.2_Missense_Mutation_p.I255M|EIF4G3_uc001bee.2_Missense_Mutation_p.I262M|EIF4G3_uc001beg.2_Missense_Mutation_p.I255M|EIF4G3_uc010odk.1_Missense_Mutation_p.I256M|EIF4G3_uc001beh.2_Missense_Mutation_p.I267M	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	256					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CTATGGATACTATTGCAGTAG	0.483													49	103					0	0	0	0	C	21268711	C	C	21268711	3	2	294	1	0	0	0	0	1	0	0	0	5062	1512	53	5	4085	5	EIF4G3	1	21268711	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	8825634	21268711	227981910	2	54003											
RAP1GAP	5909	broad.mit.edu	37	chr1	21936074	21936074	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggggtgcccctcaccttcctGaacacagcggggtccgggag	6	6	15	14	2	1	1	1	1	0	0	3	2	3	2	5	5	3	0	5	5	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:21936074G>A	uc001bex.2	-	15	1323	c.1065C>T	c.(1063-1065)TTC>TTT	p.F355F	RAP1GAP_uc001bev.2_Silent_p.F355F|RAP1GAP_uc001bew.2_Silent_p.F419F|RAP1GAP_uc001bey.2_Silent_p.F355F	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	355	Rap-GAP.				regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		TCACCTTCCTGAACACAGCGG	0.612													59	182					0	0	0	0	A	21936074	A	A	21936074	2	1	294	1	0	0	0	0	0	0	0	1	13102	1281	45	2		2	RAP1GAP	1	21936074	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	667363	21936074	227314547	3	54004											
SFRS4	6429	broad.mit.edu	37	chr1	29475724	29475724	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggctccggctcttgctccggGagcgggagcccgacctgagg	4	6	17	14	4	1	1	0	1	1	0	3	4	3	3	4	5	3	3	4	5	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:29475724G>A	uc001bro.2	-	6	1056	c.683C>T	c.(682-684)TCC>TTC	p.S228F	SFRS4_uc010ofy.1_Silent_p.L126L	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	228	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		cTTGCTCCGGGAGCGGGAGCC	0.433													7	26					0	0	0	0	A	29475724	A	A	29475724	3	1	294	1	0	0	0	0	1	0	0	0	14244	1174	41	2	805	2	SFRS4	1	29475724	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	7539650	29475724	219774897	4	54005											
ZNF643	65243	broad.mit.edu	37	chr1	40922676	40922677	+	Missense_Mutation	DNP	GG	TT	TT																															caggaggagtgggggcagctGgcccctgctcaccggaatct																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:40922676_40922677GG>TT	uc001cfn.1	+	3	570_571	c.273_274GG>TT	c.(271-276)CTGGCC>CTTTCC	p.A92S	ZNF643_uc001cfl.1_5'UTR|ZNF643_uc001cfm.1_5'UTR	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	92	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			GGGGGCAGCTGGCCCCTGCTCA	0.515													15	29					0	0	0	0	TT	40922677	TT	TT	40922676	3	4	294	1	0	0	0	0	1	0	0	0	18126	1335	47	4	283	4	ZNF643	1	40922676	Missense_Mutation	DNP	GG	TCGA-DQ-7595-01A-11D-2229-08	11446952	40922676	208327945	5	54006											
CDC20	991	broad.mit.edu	37	chr1	43824947	43824947	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcagctggatgcacccatcCccaatgcaccccctgcgcgc	7	7	8	19	2	1	0	1	0	0	0	2	1	2	1	5	1	4	3	5	1	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:43824947C>T	uc001cix.2	+	2	162	c.61C>T	c.(61-63)CCC>TCC	p.P21S	CDC20_uc001ciy.2_Missense_Mutation_p.P21S	NM_001255	NP_001246	Q12834	CDC20_HUMAN	cell division cycle 20	21					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TGCACCCATCCCCAATGCACC	0.697													29	103					0	0	0	0	T	43824947	T	T	43824947	3	4	294	1	0	0	0	0	1	0	0	0	3074	623	22	4	63	4	CDC20	1	43824947	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2902271	43824947	205425674	6	54007											
LEPR	3953	broad.mit.edu	37	chr1	66102514	66102514	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagggtatcgtgcccattccCagccccctgtttattcacgg	7	11	9	14	2	1	0	1	0	0	0	3	0	2	0	4	2	2	2	4	2	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:66102514C>A	uc001dci.2	+	20	3516	c.3314C>A	c.(3313-3315)CCA>CAA	p.P1105Q	LEPR_uc009waq.2_3'UTR	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	1105	Cytoplasmic (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TGCCCATTCCCAGCCCCCTGT	0.398													7	31					0.00448238	0.00459091	1	0	A	66102514	A	A	66102514	3	1	294	1	0	0	0	0	1	0	0	0	8768	594	21	4	3614	4	LEPR	1	66102514	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	22277567	66102514	183148107	7	54008											
NEGR1	257194	broad.mit.edu	37	chr1	72163747	72163747	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgacacatcattttccgcaCtgcattcatattccccagcc	10	12	4	15	1	2	1	2	1	0	0	4	1	4	1	4	0	2	2	4	0	1	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:72163747C>A	uc001dfw.2	-	4	711	c.611G>T	c.(610-612)AGT>ATT	p.S204I	NEGR1_uc001dfv.2_Missense_Mutation_p.S76I|NEGR1_uc010oqs.1_Intron	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	204	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		ATTTTCCGCACTGCATTCATA	0.353													20	69					1.96292e-10	2.37913e-10	1	0	A	72163747	A	A	72163747	3	1	294	1	0	0	0	0	1	0	0	0	10371	565	20	4	469	4	NEGR1	1	72163747	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	6061233	72163747	177086874	8	54009											
C1orf173	127254	broad.mit.edu	37	chr1	75036915	75036915	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcactggaagtgttgccatCgcctgtagactctccggact	7	12	10	12	2	2	1	1	0	1	1	4	3	2	3	3	2	1	2	3	2	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:75036915C>A	uc001dgg.2	-	14	4698	c.4479G>T	c.(4477-4479)GCG>GCT	p.A1493A		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1493										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTGTTGCCATCGCCTGTAGAC	0.522													54	160					3.73128e-16	4.99472e-16	1	0	A	75036915	A	A	75036915	2	1	294	1	0	0	0	0	0	0	0	1	2023	871	31	3		3	C1orf173	1	75036915	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2873168	75036915	174213706	9	54010											
ABCA4	24	broad.mit.edu	37	chr1	94544242	94544242	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacttcctaacgtgttccagTtcttcaaaagttgagttggc	10	14	8	9	1	2	1	1	1	1	0	4	1	4	1	2	1	2	4	2	1	4	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:94544242T>A	uc001dqh.2	-	10	1364	c.1260A>T	c.(1258-1260)GAA>GAT	p.E420D	ABCA4_uc010otn.1_Missense_Mutation_p.E420D	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	420	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CGTGTTCCAGTTCTTCAAAAG	0.443													55	173					0	0	0	0	A	94544242	A	A	94544242	3	1	294	1	0	0	0	0	1	0	0	0	34	1722	60	5	5725	5	ABCA4	1	94544242	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	19507327	94544242	154706379	10	54011											
AMY2B	280	broad.mit.edu	37	chr1	104117863	104117863	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	aggaactggggagaaggttgGggtttcatgccttctgacag	9	10	16	6	0	2	2	1	1	1	1	2	4	2	3	1	6	2	2	1	6	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:104117863G>T	uc001duq.2	+	8	1513	c.897G>T	c.(895-897)TGG>TGT	p.W299C	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.W299C|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	299					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GAGAAGGTTGGGGTTTCATGC	0.418													100	574					5.70617e-39	8.74533e-39	1	0	T	104117863	T	T	104117863	3	4	294	1	0	0	0	0	1	0	0	0	595	1241	43	4	919	4	AMY2B	1	104117863	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	9573621	104117863	145132758	11	54012											
FAM63A	55793	broad.mit.edu	37	chr1	150969807	150969807	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgcttcggcctctgccgacGctccccggctgggcgtccag	2	8	14	17	5	1	0	0	0	1	0	4	1	3	0	5	3	2	3	5	3	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:150969807G>A	uc001ewf.2	-	11	3050	c.1366C>T	c.(1366-1368)CGT>TGT	p.R456C	FAM63A_uc001ewc.2_Missense_Mutation_p.R314C|FAM63A_uc010pcm.1_Missense_Mutation_p.R361C|FAM63A_uc001ewd.2_Missense_Mutation_p.R314C|FAM63A_uc001ewe.2_Missense_Mutation_p.R290C|FAM63A_uc010pcn.1_Missense_Mutation_p.R504C|FAM63A_uc001ewg.2_Missense_Mutation_p.R456C	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	456							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTCTGCCGACGCTCCCCGGCT	0.567													4	13					0	0	0	0	A	150969807	A	A	150969807	3	1	294	1	0	0	0	0	1	0	0	0	5628	1087	38	1	47	1	FAM63A	1	150969807	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	46851944	150969807	98280814	12	54013											
FLG	2312	broad.mit.edu	37	chr1	152277874	152277874	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttcctcattacgtgttgttCtgcttgcacttctggatcct	4	18	8	11	1	3	0	1	0	2	0	5	1	5	1	2	1	3	5	2	1	1	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:152277874C>G	uc001ezu.1	-	3	9524	c.9488G>C	c.(9487-9489)AGA>ACA	p.R3163T		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3163	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACGTGTTGTTCTGCTTGCACT	0.542									Ichthyosis				102	341					0	0	0	0	G	152277874	G	G	152277874	3	3	294	1	0	0	0	0	1	0	0	0	5954	913	32	2	2701	2	FLG	1	152277874	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1308067	152277874	96972747	13	54014											
CD1E	913	broad.mit.edu	37	chr1	158325293	158325293	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaatactgcaaagccttcttGgtcacacctgccctcgattt	10	12	6	13	1	2	0	1	0	1	0	3	1	2	0	3	1	4	1	3	1	3	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:158325293G>C	uc001fse.2	+	3	798	c.559G>C	c.(559-561)GGT>CGT	p.G187R	CD1E_uc010pid.1_Missense_Mutation_p.G185R|CD1E_uc010pie.1_Missense_Mutation_p.G88R|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.G187R|CD1E_uc001fsk.2_Intron|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.G187R|CD1E_uc001fry.2_Missense_Mutation_p.G187R|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.G187R|CD1E_uc009wsv.2_Missense_Mutation_p.G88R|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	187					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					AAGCCTTCTTGGTCACACCTG	0.527													11	36					0	0	0	0	C	158325293	C	C	158325293	3	2	294	1	0	0	0	0	1	0	0	0	2993	1348	47	4	569	4	CD1E	1	158325293	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	6047419	158325293	90925328	14	54015											
GPR161	23432	broad.mit.edu	37	chr1	168073877	168073878	+	Frame_Shift_Del	DEL	AG	-	-																															cggacagcaggaagttggacAgagtcaggctgaagacgaac																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:168073877_168073878delAG	uc001gfc.2	-	4	525_526	c.211_212delCT	c.(211-213)CTGfs	p.L71fs	GPR161_uc001gfb.2_Intron|GPR161_uc010pll.1_Intron|GPR161_uc010plm.1_Intron|GPR161_uc009wvo.2_Frame_Shift_Del_p.L88fs|GPR161_uc001gfd.2_Frame_Shift_Del_p.L71fs|GPR161_uc010pln.1_Frame_Shift_Del_p.L91fs|GPR161_uc001gfe.1_Frame_Shift_Del_p.L71fs	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	71	Helical; Name=2; (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					GAAGTTGGACAGAGTCAGGCTG	0.53													---	---	---								-	168073878	-	-	168073877	7	5	294	1	0	1	0	1	0	0	0	0	6703	188	7	0	1397	0	GPR161	1	168073877	Frame_Shift_Del	DEL	AG	TCGA-DQ-7595-01A-11D-2229-08	9748584	168073877	81176744	15	54016											
BLZF1	8548	broad.mit.edu	37	chr1	169345927	169345927	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagcagttccatcagagagcCcaggagttcttcagctaggg	11	8	12	10	0	3	1	2	0	1	1	4	3	4	2	2	2	3	4	2	2	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:169345927C>T	uc001gfx.1	+	3	615	c.178C>T	c.(178-180)CCA>TCA	p.P60S	BLZF1_uc001gfw.2_Missense_Mutation_p.P60S|BLZF1_uc001gfy.2_Missense_Mutation_p.P60S|BLZF1_uc009wvp.1_Missense_Mutation_p.P37S	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	60					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					ATCAGAGAGCCCAGGAGTTCT	0.423													19	64					0	0	0	0	T	169345927	T	T	169345927	3	4	294	1	0	0	0	0	1	0	0	0	1456	623	22	4	184	4	BLZF1	1	169345927	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1272050	169345927	79904694	16	54017											
RC3H1	149041	broad.mit.edu	37	chr1	173912638	173912638	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccacctggtgcagttccaagCtcaactgctcacttgagatc	9	10	8	14	0	2	1	2	1	0	1	4	2	3	1	3	1	4	4	3	1	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:173912638C>G	uc001gju.3	-	17	3164	c.3077G>C	c.(3076-3078)AGC>ACC	p.S1026T	RC3H1_uc010pms.1_Missense_Mutation_p.S1017T|RC3H1_uc001gjv.2_Missense_Mutation_p.S1017T|RC3H1_uc010pmt.1_Missense_Mutation_p.S1026T	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	1026					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CAGTTCCAAGCTCAACTGCTC	0.547													41	189					0	0	0	0	G	173912638	G	G	173912638	3	3	294	1	0	0	0	0	1	0	0	0	13231	797	28	4	336	4	RC3H1	1	173912638	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	4566711	173912638	75337983	17	54018											
RC3H1	149041	broad.mit.edu	37	chr1	173912667	173912667	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tcacttgagatcatcccaggCcattttggaggtggcggtgg	7	11	14	9	1	2	1	2	1	0	1	3	3	3	2	2	6	0	0	2	6	0	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:173912667C>G	uc001gju.3	-	17	3135	c.3048G>C	c.(3046-3048)TGG>TGC	p.W1016C	RC3H1_uc010pms.1_Missense_Mutation_p.W1007C|RC3H1_uc001gjv.2_Missense_Mutation_p.W1007C|RC3H1_uc010pmt.1_Missense_Mutation_p.W1016C	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	1016					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TCATCCCAGGCCATTTTGGAG	0.547													36	153					0	0	0	0	G	173912667	G	G	173912667	3	3	294	1	0	0	0	0	1	0	0	0	13231	740	26	4	365	4	RC3H1	1	173912667	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	29	173912667	75337954	18	54019											
TNN	63923	broad.mit.edu	37	chr1	175067630	175067630	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggaaggagcagagcagcaCagtcctgacaggcctgagac	12	3	16	10	0	0	3	0	2	0	2	1	6	1	5	2	4	3	3	2	4	1	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:175067630C>G	uc001gkl.1	+	9	2131	c.2018C>G	c.(2017-2019)ACA>AGA	p.T673R	TNN_uc010pmx.1_Missense_Mutation_p.T584R	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	673	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CAGAGCAGCACAGTCCTGACA	0.632													39	73					0	0	0	0	G	175067630	G	G	175067630	3	3	294	1	0	0	0	0	1	0	0	0	16389	478	17	4	2048	4	TNN	1	175067630	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1154963	175067630	74182991	19	54020											
PAPPA2	60676	broad.mit.edu	37	chr1	176668584	176668584	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatgagaggatagagattgAtgcagcactcctgacttctc	11	11	11	8	0	1	5	0	4	1	2	3	8	2	6	1	1	2	2	1	1	1	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:176668584A>T	uc001gkz.2	+	8	4259	c.3095A>T	c.(3094-3096)GAT>GTT	p.D1032V	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1032					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ATAGAGATTGATGCAGCACTC	0.537													27	96					0	0	0	0	T	176668584	T	T	176668584	3	4	294	1	0	0	0	0	1	0	0	0	11487	333	12	5	3174	5	PAPPA2	1	176668584	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	1600954	176668584	72582037	20	54021											
FAM5B	57795	broad.mit.edu	37	chr1	177249566	177249566	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggtccttgtcctactggtgGaaccgaatccagtccctcct	7	11	9	14	1	0	0	0	0	0	0	5	2	5	1	6	3	2	0	6	3	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:177249566G>T	uc001glf.2	+	8	1566	c.1254G>T	c.(1252-1254)TGG>TGT	p.W418C	FAM5B_uc001glg.2_Missense_Mutation_p.W313C	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	418						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CCTACTGGTGGAACCGAATCC	0.507													24	92					1.12875e-08	1.31532e-08	1	0	T	177249566	T	T	177249566	3	4	294	1	0	0	0	0	1	0	0	0	5625	1183	41	2	1280	2	FAM5B	1	177249566	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	580982	177249566	72001055	21	54022											
CFHR5	81494	broad.mit.edu	37	chr1	196973962	196973962	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taaacagtggtcagaaccacCaagatgcctaggtgagttct	13	9	10	9	0	2	3	1	1	1	2	2	3	2	3	3	2	3	1	3	2	5	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:196973962C>T	uc001gts.3	+	9	1630	c.1502C>T	c.(1501-1503)CCA>CTA	p.P501L		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	501	Sushi 8.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TCAGAACCACCAAGATGCCTA	0.373													19	55					0	0	0	0	T	196973962	T	T	196973962	3	4	294	1	0	0	0	0	1	0	0	0	3303	594	21	4	1536	4	CFHR5	1	196973962	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	19724396	196973962	52276659	22	54023											
CRB1	23418	broad.mit.edu	37	chr1	197446935	197446935	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggaacctacagccccagcCgtcaggagaaggagggctcc	11	3	14	13	1	1	1	1	0	0	1	2	4	2	3	5	4	4	1	5	4	3	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:197446935C>A	uc001gtz.2	+	12	4282	c.4147C>A	c.(4147-4149)CGT>AGT	p.R1383S	CRB1_uc010poz.1_Missense_Mutation_p.R1359S|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.R1271S|CRB1_uc010ppb.1_Missense_Mutation_p.R847S|CRB1_uc010ppd.1_Missense_Mutation_p.R864S	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1383	Cytoplasmic (Potential).		R -> H (in RP12).		cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CAGCCCCAGCCGTCAGGAGAA	0.542													24	63					3.7963e-18	5.23074e-18	1	0	A	197446935	A	A	197446935	3	1	294	1	0	0	0	0	1	0	0	0	3863	652	23	3	4193	3	CRB1	1	197446935	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	472973	197446935	51803686	23	54024											
PPP1R12B	4660	broad.mit.edu	37	chr1	202406978	202406978	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggcctttttaacaagccagaAgagcccaaagatgaatctcc	14	8	8	11	0	1	4	0	1	1	3	2	4	1	4	4	1	3	0	4	1	5	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:202406978A>G	uc001gya.1	+	10	1428	c.1284A>G	c.(1282-1284)GAA>GAG	p.E428E	PPP1R12B_uc001gxy.2_Silent_p.E428E|PPP1R12B_uc009xad.1_Silent_p.E234E|PPP1R12B_uc009xae.1_3'UTR|PPP1R12B_uc001gxz.1_Silent_p.E428E	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	428					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			ACAAGCCAGAAGAGCCCAAAG	0.413													19	47					0	0	0	0	G	202406978	G	G	202406978	2	3	294	1	0	0	0	0	0	0	0	1	12415	69	3	5		5	PPP1R12B	1	202406978	Silent	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	4960043	202406978	46843643	24	54025											
USH2A	7399	broad.mit.edu	37	chr1	216074184	216074184	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tattacgagctggtgtagacCagacaacctgaagactggtt	12	10	11	8	1	0	4	0	1	0	3	0	5	0	4	2	2	3	3	2	2	5	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:216074184C>A	uc001hku.1	-	39	7751	c.7364G>T	c.(7363-7365)TGG>TTG	p.W2455L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2455	Extracellular (Potential).|Fibronectin type-III 11.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTGTAGACCAGACAACCTG	0.512										HNSCC(13;0.011)			37	96					4.17593e-13	5.2729e-13	1	0	A	216074184	A	A	216074184	3	1	294	1	0	0	0	0	1	0	0	0	17104	595	21	4	8380	4	USH2A	1	216074184	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	13667206	216074184	33176437	25	54026											
USH2A	7399	broad.mit.edu	37	chr1	216262432	216262432	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcatgccattttccatcaCtatattgtttgccatgatca	9	18	4	10	0	3	1	3	1	0	0	4	1	4	1	3	0	2	1	3	0	2	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:216262432C>T	uc001hku.1	-	23	5195	c.4808G>A	c.(4807-4809)AGT>AAT	p.S1603N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1603	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTTTCCATCACTATATTGTTT	0.333										HNSCC(13;0.011)			30	116					0	0	0	0	T	216262432	T	T	216262432	3	4	294	1	0	0	0	0	1	0	0	0	17104	565	20	4	11000	4	USH2A	1	216262432	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	188248	216262432	32988189	26	54027											
SLC30A10	55532	broad.mit.edu	37	chr1	220101747	220101747	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acggtgagcaccagcatgaaGagcagccggcacgtcttgcc	10	5	13	13	3	1	3	0	2	1	1	1	3	1	3	3	2	5	4	3	2	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:220101747G>C	uc001hlw.2	-	1	247	c.36C>G	c.(34-36)CTC>CTG	p.L12L	SLC30A10_uc001hlu.1_Intron|SLC30A10_uc001hlx.2_5'UTR	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),	12	Helical; (Potential).				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		CCAGCATGAAGAGCAGCCGGC	0.587													10	29					0	0	0	0	C	220101747	C	C	220101747	2	2	294	1	0	0	0	0	0	0	0	1	14618	929	33	2		2	SLC30A10	1	220101747	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3839315	220101747	29148874	27	54028											
ZP4	57829	broad.mit.edu	37	chr1	238050152	238050152	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagttcattttcatatactGctcggtctccagtgatctac	8	15	6	12	1	4	1	2	1	2	0	6	1	4	1	2	1	3	2	2	1	3	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:238050152G>A	uc001hym.2	-	6	758	c.758C>T	c.(757-759)GCA>GTA	p.A253V	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	253	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TTCATATACTGCTCGGTCTCC	0.468													24	78					0	0	0	0	A	238050152	A	A	238050152	3	1	294	1	0	0	0	0	1	0	0	0	18285	1319	46	4	892	4	ZP4	1	238050152	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	17948405	238050152	11200469	28	54029											
FMN2	56776	broad.mit.edu	37	chr1	240370796	240370796	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gcctactctgcccagtacagCcattccccaacctcctcctc	7	9	4	21	0	1	0	0	0	1	0	5	0	4	0	8	0	5	1	8	0	3	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:240370796C>A	uc010pyd.1	+	5	2909	c.2684C>A	c.(2683-2685)GCC>GAC	p.A895D	FMN2_uc010pye.1_Missense_Mutation_p.A899D	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	895	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCAGTACAGCCATTCCCCAA	0.657													76	199					1.21826e-31	1.84044e-31	1	0	A	240370796	A	A	240370796	3	1	294	1	0	0	0	0	1	0	0	0	5982	739	26	4	2702	4	FMN2	1	240370796	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2320644	240370796	8879825	29	54030											
NLRP3	114548	broad.mit.edu	37	chr1	247607419	247607419	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tctgtgagggactcttgcacCccgactgcaagcttcaggtg	7	10	12	12	1	3	1	1	1	2	0	3	3	3	2	2	2	3	3	2	2	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:247607419C>A	uc001icr.2	+	9	2953	c.2815C>A	c.(2815-2817)CCC>ACC	p.P939T	NLRP3_uc001ics.2_Missense_Mutation_p.P882T|NLRP3_uc001icu.2_Missense_Mutation_p.P939T|NLRP3_uc001icw.2_Missense_Mutation_p.P882T|NLRP3_uc001icv.2_Missense_Mutation_p.P825T|NLRP3_uc010pyw.1_Missense_Mutation_p.P917T	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	939					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ACTCTTGCACCCCGACTGCAA	0.522													14	56					1.99824e-07	2.23612e-07	1	0	A	247607419	A	A	247607419	3	1	294	1	0	0	0	0	1	0	0	0	10532	623	22	4	2841	4	NLRP3	1	247607419	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	7236623	247607419	1643202	30	54031											
OR6F1	343169	broad.mit.edu	37	chr1	247875546	247875546	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agaagtggttgatggcacggGggccacagaaggacaggcca	12	4	17	8	1	0	3	0	1	0	2	0	4	0	4	2	6	0	2	2	6	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:247875546G>T	uc001idj.1	-	1	512	c.512C>A	c.(511-513)CCC>CAC	p.P171H		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GATGGCACGGGGGCCACAGAA	0.597													37	109					9.62906e-15	1.25713e-14	1	0	T	247875546	T	T	247875546	3	4	294	1	0	0	0	0	1	0	0	0	11255	1232	43	4	418	4	OR6F1	1	247875546	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	268127	247875546	1375075	31	54032											
OR2L3	391192	broad.mit.edu	37	chr1	248224614	248224615	+	Frame_Shift_Ins	INS	-	T	T																															ctttctcgtgtttcccttcaINSttgctatttcatgttcctat																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:248224614_248224615insT	uc001idx.1	+	1	631_632	c.631_632insT	c.(631-633)ATTfs	p.I211fs	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GTTTCCCTTCATTGCTATTTCA	0.52													---	---	---								T	248224615	T	T	248224614	7	5	294	1	0	1	1	0	0	0	0	0	11062	217	8	0	633	0	OR2L3	1	248224614	Frame_Shift_Ins	INS	-	TCGA-DQ-7595-01A-11D-2229-08	349068	248224614	1026007	32	54033											
OR2T1	26696	broad.mit.edu	37	chr1	248569335	248569335	+	Frame_Shift_Del	DEL	C	-	-																															ttttaaatgttttcttcccaCttttaaaagtttgctgccta																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:248569335delC	uc010pzm.1	+	1	40	c.40delC	c.(40-42)CTTfs	p.L14fs		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTTCTTCCCACTTTTAAAAGT	0.308													---	---	---								-	248569335	-	-	248569335	7	5	294	1	0	1	0	1	0	0	0	0	11070	565	20	0	42	0	OR2T1	1	248569335	Frame_Shift_Del	DEL	C	TCGA-DQ-7595-01A-11D-2229-08	344721	248569335	681286	33	54034											
OR2T1	26696	broad.mit.edu	37	chr1	248569862	248569862	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cctgtcctcatgagccgccgGgtctgttggatgattatagc	6	12	12	11	2	2	2	1	2	1	0	3	3	3	3	4	2	2	1	4	2	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr1:248569862G>T	uc010pzm.1	+	1	567	c.567G>T	c.(565-567)CGG>CGT	p.R189R		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	189	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGAGCCGCCGGGTCTGTTGGA	0.557													36	70					1.69901e-12	2.13259e-12	1	0	T	248569862	T	T	248569862	2	4	294	1	0	0	0	0	0	0	0	1	11070	1219	43	4		4	OR2T1	1	248569862	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	527	248569862	680759	34	54035											
GTF3C2	2976	broad.mit.edu	37	chr2	27551754	27551754	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cagtgaagtaggccttgaaaCcaaggtaaccagcgtcaata	15	7	10	9	1	1	2	1	2	0	0	1	2	1	2	3	2	3	2	3	2	7	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:27551754C>G	uc002rjv.1	-	16	2447	c.2084G>C	c.(2083-2085)GGT>GCT	p.G695A	GTF3C2_uc010eyy.1_Missense_Mutation_p.G150A|GTF3C2_uc002rju.1_Missense_Mutation_p.G706A|GTF3C2_uc002rjw.1_Missense_Mutation_p.G695A	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	695						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCTTGAAACCAAGGTAACC	0.393													22	15					0	0	0	0	G	27551754	G	G	27551754	3	3	294	1	0	0	0	0	1	0	0	0	6912	507	18	4	671	4	GTF3C2	2	27551754	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08		27551754	215647619	35	54036											
FEZ2	9637	broad.mit.edu	37	chr2	36805971	36805971	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcagtctcaatttcttccagGatttcatttaactcagacac	11	14	5	11	0	4	1	3	0	2	1	6	2	5	2	1	1	1	1	1	1	2	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:36805971G>C	uc002rph.2	-	5	719	c.672C>G	c.(670-672)ATC>ATG	p.I224M	FEZ2_uc002rpe.2_Missense_Mutation_p.I53M|FEZ2_uc002rpf.2_Missense_Mutation_p.I53M|FEZ2_uc002rpg.2_Missense_Mutation_p.I224M|FEZ2_uc002rpi.2_Missense_Mutation_p.I79M|FEZ2_uc002rpj.2_Missense_Mutation_p.I224M	NM_005102	NP_005093	Q9UHY8	FEZ2_HUMAN	zygin 2 isoform 1	224	Potential.				axon guidance|signal transduction		protein binding			ovary(1)	1		all_hematologic(82;0.21)				TTTCTTCCAGGATTTCATTTA	0.398													10	52					0	0	0	0	C	36805971	C	C	36805971	3	2	294	1	0	0	0	0	1	0	0	0	5856	1164	41	2	490	2	FEZ2	2	36805971	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	9254217	36805971	206393402	36	54037											
VRK2	7444	broad.mit.edu	37	chr2	58373462	58373462	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taccaacaggttgattcacaAaaggctgcaacaaagcaagt	17	7	8	9	0	1	1	1	1	0	0	1	1	1	1	1	2	5	4	1	2	7	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:58373462A>G	uc002rzo.2	+	15	1780	c.1035A>G	c.(1033-1035)CAA>CAG	p.Q345Q	VRK2_uc010fcb.2_Silent_p.Q345Q|VRK2_uc002rzs.2_Silent_p.Q345Q|VRK2_uc002rzr.2_Silent_p.Q345Q|VRK2_uc010fcc.2_Silent_p.Q227Q|VRK2_uc002rzv.2_Silent_p.Q345Q|VRK2_uc010fcd.2_Silent_p.Q322Q|VRK2_uc002rzp.2_Silent_p.Q345Q|VRK2_uc010ypg.1_Silent_p.Q345Q|VRK2_uc002rzq.2_Silent_p.Q345Q|VRK2_uc002rzu.2_Silent_p.Q345Q|VRK2_uc002rzt.2_Silent_p.Q227Q	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	vaccinia related kinase 2 isoform 2	345						integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						TTGATTCACAAAAGGCTGCAA	0.358													5	26					0	0	0	0	G	58373462	G	G	58373462	2	3	294	1	0	0	0	0	0	0	0	1	17288	11	1	5		5	VRK2	2	58373462	Silent	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	21567491	58373462	184825911	37	54038											
ACTR2	10097	broad.mit.edu	37	chr2	65482681	65482681	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gctattgttttgtaccagctActtctgttgcgaggatacgc	7	15	10	9	2	1	0	0	0	1	0	1	2	1	1	1	1	5	5	1	1	4	9			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:65482681A>C	uc002sdq.2	+	6	803	c.588A>C	c.(586-588)CTA>CTC	p.L196L	ACTR2_uc010yqf.1_Silent_p.L141L|ACTR2_uc002sdp.2_Silent_p.L201L|ACTR2_uc010yqg.1_Silent_p.L144L	NM_005722	NP_005713	P61160	ARP2_HUMAN	actin-related protein 2 isoform b	196					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding				0						TGTACCAGCTACTTCTGTTGC	0.358													26	118					0	0	0	0	C	65482681	C	C	65482681	2	2	294	1	0	0	0	0	0	0	0	1	211	378	14	5		5	ACTR2	2	65482681	Silent	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	7109219	65482681	177716692	38	54039											
CTNNA2	1496	broad.mit.edu	37	chr2	80646682	80646682	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatgaaaaggaagtgaaaGaatatgcccaagttttccgt	17	9	10	5	1	0	3	0	2	0	1	1	5	1	4	2	1	1	1	2	1	8	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:80646682G>T	uc010ysh.1	+	8	1251	c.1246G>T	c.(1246-1248)GAA>TAA	p.E416*	CTNNA2_uc010yse.1_Nonsense_Mutation_p.E416*|CTNNA2_uc010ysf.1_Nonsense_Mutation_p.E416*|CTNNA2_uc010ysg.1_Nonsense_Mutation_p.E416*|CTNNA2_uc010ysi.1_Nonsense_Mutation_p.E48*	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	416					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GGAAGTGAAAGAATATGCCCA	0.448													28	70					1.75199e-13	2.23894e-13	1	0	T	80646682	T	T	80646682	4	4	294	1	0	0	0	0	0	1	0	0	4030	943	33	2	1068	2	CTNNA2	2	80646682	Nonsense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	15164001	80646682	162552691	39	54040											
SMYD1	150572	broad.mit.edu	37	chr2	88387425	88387425	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggtggagagagaaggcaccgGgctcacggagggctgcctgg	8	4	20	9	2	1	2	1	0	0	2	1	5	1	3	2	7	1	3	2	7	1	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:88387425G>T	uc002ssr.2	+	3	361	c.359G>T	c.(358-360)GGG>GTG	p.G120V	SMYD1_uc002ssq.1_Intron	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GAAGGCACCGGGCTCACGGAG	0.602													12	66					1.08611e-07	1.22187e-07	1	0	T	88387425	T	T	88387425	3	4	294	1	0	0	0	0	1	0	0	0	14885	1232	43	4	369	4	SMYD1	2	88387425	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	7740743	88387425	154811948	40	54041											
GCC2	9648	broad.mit.edu	37	chr2	109098761	109098761	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtgaaacaataaattctGataatgaagatctcctggct	15	12	8	6	0	2	4	0	3	2	1	3	4	2	4	1	1	1	1	1	1	6	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:109098761G>T	uc002tec.2	+	11	3353	c.3199G>T	c.(3199-3201)GAT>TAT	p.D1067Y	GCC2_uc002ted.2_Missense_Mutation_p.D966Y	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1067	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AATAAATTCTGATAATGAAGA	0.333													20	69					3.01185e-09	3.53892e-09	1	0	T	109098761	T	T	109098761	3	4	294	1	0	0	0	0	1	0	0	0	6321	1290	45	2	3241	2	GCC2	2	109098761	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	20711336	109098761	134100612	41	54042											
CNTNAP5	129684	broad.mit.edu	37	chr2	125504927	125504927	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagagctgcctggacattcaGcacttttgcaattgcgacgc	9	10	11	11	2	1	1	1	0	0	1	1	4	1	2	1	1	5	3	1	1	1	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:125504927G>T	uc002tno.2	+	14	2560	c.2196G>T	c.(2194-2196)CAG>CAT	p.Q732H	CNTNAP5_uc010flu.2_Missense_Mutation_p.Q733H	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	732	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGGACATTCAGCACTTTTGCA	0.493													40	161					2.00842e-17	2.74052e-17	1	0	T	125504927	T	T	125504927	3	4	294	1	0	0	0	0	1	0	0	0	3665	962	34	4	2250	4	CNTNAP5	2	125504927	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	16406166	125504927	117694446	42	54043											
THSD7B	80731	broad.mit.edu	37	chr2	137814025	137814025	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtacaggagactgtggtcccGgaggagtccagagtcgggca	9	6	17	9	2	0	2	0	0	0	2	3	5	2	4	2	5	1	2	2	5	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:137814025G>T	uc002tva.1	+	2	82	c.82G>T	c.(82-84)GGA>TGA	p.G28*	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_5'UTR	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTGTGGTCCCGGAGGAGTCCA	0.493													17	79					7.41877e-09	8.6689e-09	1	0	T	137814025	T	T	137814025	4	4	294	1	0	0	0	0	0	1	0	0	15946	1117	39	3	88	3	THSD7B	2	137814025	Nonsense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	12309098	137814025	105385348	43	54044											
LRP1B	53353	broad.mit.edu	37	chr2	141083346	141083346	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaccttgtttgctgctgaCagagactactgaattagagc	12	11	9	9	0	0	4	0	2	0	2	0	5	0	4	1	0	5	3	1	0	4	4	rs141655851	byFrequency	TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:141083346C>T	uc002tvj.1	-	80	13297	c.12325G>A	c.(12325-12327)GTC>ATC	p.V4109I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4109	Extracellular (Potential).|LDL-receptor class B 36.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGCTGCTGACAGAGACTACT	0.358										TSP Lung(27;0.18)			17	70					0	0	0	0	T	141083346	T	T	141083346	3	4	294	1	0	0	0	0	1	0	0	0	9005	478	17	4	1522	4	LRP1B	2	141083346	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3269321	141083346	102116027	44	54045											
UPP2	151531	broad.mit.edu	37	chr2	158958578	158958578	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcacatagtagagagaatGgcttcagttatacctgcctc	11	13	8	9	0	2	2	2	0	0	2	3	3	2	2	2	1	2	3	2	1	5	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:158958578G>A	uc002tzp.2	+	1	197	c.3G>A	c.(1-3)ATG>ATA	p.M1I	UPP2_uc002tzo.2_Missense_Mutation_p.M58I	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	1					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						TAGAGAGAATGGCTTCAGTTA	0.333													50	145					0	0	0	0	A	158958578	A	A	158958578	3	1	294	1	0	0	0	0	1	0	0	0	17081	1348	47	4	184	4	UPP2	2	158958578	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	17875232	158958578	84240795	45	54046											
LY75	4065	broad.mit.edu	37	chr2	160710981	160710981	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcatagtttaggtgaaGatcagcaacaaaccaatatt	15	13	6	7	0	3	2	2	1	1	1	3	2	3	2	1	1	3	2	1	1	7	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:160710981G>T	uc002ubc.3	-	18	2554	c.2485C>A	c.(2485-2487)CTT>ATT	p.L829I	LY75_uc002ubb.3_Missense_Mutation_p.L829I|LY75_uc010fos.2_Missense_Mutation_p.L829I	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	829	Extracellular (Potential).|C-type lectin 5.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TTTAGGTGAAGATCAGCAACA	0.378													29	78					1.13719e-10	1.38227e-10	1	0	T	160710981	T	T	160710981	3	4	294	1	0	0	0	0	1	0	0	0	9150	942	33	2	2755	2	LY75	2	160710981	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1752403	160710981	82488392	46	54047											
SLC4A10	57282	broad.mit.edu	37	chr2	162761309	162761309	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaattgaatctctctttggAgcatccatgaccgggatagc	10	11	10	10	1	2	2	0	2	2	0	4	4	3	4	2	2	2	2	2	2	3	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:162761309A>G	uc002ubx.3	+	14	1825	c.1641A>G	c.(1639-1641)GGA>GGG	p.G547G	SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Silent_p.G517G|SLC4A10_uc010zcs.1_Silent_p.G528G	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	547	Helical; (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CTCTCTTTGGAGCATCCATGA	0.398													34	142					0	0	0	0	G	162761309	G	G	162761309	2	3	294	1	0	0	0	0	0	0	0	1	14715	291	11	5		5	SLC4A10	2	162761309	Silent	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	2050328	162761309	80438064	47	54048											
FIGN	55137	broad.mit.edu	37	chr2	164466801	164466801	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccgaggtaaggccgtcagtCcactgaacgcgtctgacctc	8	8	11	14	4	2	2	1	2	1	0	5	3	4	2	4	2	1	1	4	2	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:164466801C>A	uc002uck.1	-	3	1852	c.1541G>T	c.(1540-1542)GGA>GTA	p.G514V		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	514						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						GGCCGTCAGTCCACTGAACGC	0.527													17	54					3.32936e-07	3.7061e-07	1	0	A	164466801	A	A	164466801	3	1	294	1	0	0	0	0	1	0	0	0	5923	855	30	2	742	2	FIGN	2	164466801	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1705492	164466801	78732572	48	54049											
FASTKD1	79675	broad.mit.edu	37	chr2	170403042	170403042	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caaatacatgtgatcatgctGaatccatcttaaaacagatg	16	11	6	8	0	2	3	1	2	1	1	3	3	3	3	1	0	3	1	1	0	5	2	rs148253352	by1000genomes	TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:170403042G>A	uc002uev.3	-	8	1775	c.1387C>T	c.(1387-1389)CAG>TAG	p.Q463*	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Nonsense_Mutation_p.Q449*	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	463					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						TGATCATGCTGAATCCATCTT	0.398													26	71					0	0	0	0	A	170403042	A	A	170403042	4	1	294	1	0	0	0	0	0	1	0	0	5717	1299	45	2	1188	2	FASTKD1	2	170403042	Nonsense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	5936241	170403042	72796331	49	54050											
HOXD12	3238	broad.mit.edu	37	chr2	176964665	176964665	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttccccctatctcctacccgCgcggcgcgctgccctgggcc	2	8	10	21	5	1	0	0	0	1	0	3	0	2	0	6	2	2	1	6	2	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:176964665C>A	uc010zev.1	+	1	136	c.136C>A	c.(136-138)CGC>AGC	p.R46S	HOXD12_uc010zew.1_Missense_Mutation_p.R46S	NM_021193	NP_067016	P35452	HXD12_HUMAN	homeobox D12	46				GGQLAALPPISYPRG -> AASLAFPLSPTRA (in Ref. 1; AAF79044).		nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		CTCCTACCCGCGCGGCGCGCT	0.711													13	41					4.36969e-10	5.22141e-10	1	0	A	176964665	A	A	176964665	3	1	294	1	0	0	0	0	1	0	0	0	7360	768	27	3	138	3	HOXD12	2	176964665	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	6561623	176964665	66234708	50	54051											
TTN	7273	broad.mit.edu	37	chr2	179419652	179419652	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggcattccttagttttaattCatagcatccactattaaggc	11	15	6	9	0	1	0	1	0	0	0	3	0	3	0	2	2	1	3	2	2	5	8			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:179419652C>G	uc010zfg.1	-	280	81054	c.80830G>C	c.(80830-80832)GAA>CAA	p.E26944Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E20639Q|TTN_uc010zfi.1_Missense_Mutation_p.E20572Q|TTN_uc010zfj.1_Missense_Mutation_p.E20447Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27871							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTTTAATTCATAGCATCCA	0.433													13	39					0	0	0	0	G	179419652	G	G	179419652	3	3	294	1	0	0	0	0	1	0	0	0	16803	835	29	2	19573	2	TTN	2	179419652	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2454987	179419652	63779721	51	54052											
TTN	7273	broad.mit.edu	37	chr2	179429100	179429100	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctatcagatggttcactaaaGtttccagctgcatttcttgc	9	15	7	10	0	3	1	2	0	1	1	4	1	4	1	1	1	3	4	1	1	3	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:179429100G>T	uc010zfg.1	-	275	74279	c.74055C>A	c.(74053-74055)AAC>AAA	p.N24685K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N18380K|TTN_uc010zfi.1_Missense_Mutation_p.N18313K|TTN_uc010zfj.1_Missense_Mutation_p.N18188K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25612							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTCACTAAAGTTTCCAGCTG	0.378													20	42					8.34094e-07	9.1642e-07	1	0	T	179429100	T	T	179429100	3	4	294	1	0	0	0	0	1	0	0	0	16803	1020	36	4	26368	4	TTN	2	179429100	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	9448	179429100	63770273	52	54053											
TTN	7273	broad.mit.edu	37	chr2	179439997	179439997	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctgctccttgacaatgacgGgtctgctttctctaggggca	6	13	11	11	1	3	2	0	2	3	0	5	2	4	2	1	3	2	3	1	3	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:179439997G>A	uc010zfg.1	-	275	63382	c.63158C>T	c.(63157-63159)CCC>CTC	p.P21053L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P14748L|TTN_uc010zfi.1_Missense_Mutation_p.P14681L|TTN_uc010zfj.1_Missense_Mutation_p.P14556L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21980							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACAATGACGGGTCTGCTTTC	0.478													11	35					0	0	0	0	A	179439997	A	A	179439997	3	1	294	1	0	0	0	0	1	0	0	0	16803	1232	43	4	37265	4	TTN	2	179439997	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	10897	179439997	63759376	53	54054											
TTN	7273	broad.mit.edu	37	chr2	179440030	179440030	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taggggcacttctccccgcgCtgttcactgccatcacttgg	5	11	10	15	2	3	0	2	0	1	0	4	0	3	0	3	3	1	3	3	3	1	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:179440030C>T	uc010zfg.1	-	275	63349	c.63125G>A	c.(63124-63126)AGC>AAC	p.S21042N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S14737N|TTN_uc010zfi.1_Missense_Mutation_p.S14670N|TTN_uc010zfj.1_Missense_Mutation_p.S14545N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21969							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCCCCGCGCTGTTCACTGC	0.507													8	39					0	0	0	0	T	179440030	T	T	179440030	3	4	294	1	0	0	0	0	1	0	0	0	16803	797	28	4	37298	4	TTN	2	179440030	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	33	179440030	63759343	54	54055											
TTN	7273	broad.mit.edu	37	chr2	179453495	179453495	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccaccatcatattcaggtGgattccaaaccacagtcatc	12	11	5	13	0	3	0	3	0	0	0	6	1	5	1	4	2	1	0	4	2	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:179453495G>T	uc010zfg.1	-	253	55477	c.55253C>A	c.(55252-55254)CCA>CAA	p.P18418Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P12113Q|TTN_uc010zfi.1_Missense_Mutation_p.P12046Q|TTN_uc010zfj.1_Missense_Mutation_p.P11921Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19345							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATTCAGGTGGATTCCAAAC	0.428													14	51					0.000308642	0.000322359	1	0	T	179453495	T	T	179453495	3	4	294	1	0	0	0	0	1	0	0	0	16803	1348	47	4	45258	4	TTN	2	179453495	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	13465	179453495	63745878	55	54056											
TTN	7273	broad.mit.edu	37	chr2	179579026	179579026	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctttttactaaccgagaacGgatagcgtggcgaagcactc	11	10	10	10	4	1	1	0	0	1	1	2	4	1	2	1	2	5	1	1	2	5	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:179579026G>T	uc010zfg.1	-	88	22967	c.22743C>A	c.(22741-22743)TCC>TCA	p.S7581S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.S4242S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8508							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACCGAGAACGGATAGCGTGG	0.398													40	170					3.94638e-17	5.35038e-17	1	0	T	179579026	T	T	179579026	2	4	294	1	0	0	0	0	0	0	0	1	16803	1103	39	3		3	TTN	2	179579026	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	125531	179579026	63620347	56	54057											
TTN	7273	broad.mit.edu	37	chr2	179598218	179598218	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgctgtcacctggatcagttCtgctcgctcaatgattttgg	6	15	10	10	1	4	1	3	1	1	0	5	2	4	2	1	2	2	4	1	2	1	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:179598218C>G	uc010zfg.1	-	51	12294	c.12070G>C	c.(12070-12072)GAA>CAA	p.E4024Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E685Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4951							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGATCAGTTCTGCTCGCTCA	0.458													78	262					0	0	0	0	G	179598218	G	G	179598218	3	3	294	1	0	0	0	0	1	0	0	0	16803	922	32	2	88963	2	TTN	2	179598218	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	19192	179598218	63601155	57	54058											
TTN	7273	broad.mit.edu	37	chr2	179616519	179616519	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggccgattgttatgaaaccaAgtcatttctggagttggaca	11	12	11	7	1	2	1	1	1	1	0	2	4	2	3	2	3	1	2	2	3	3	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:179616519A>G	uc002unb.2	-	46	10832	c.10608T>C	c.(10606-10608)ACT>ACC	p.T3536T	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATGAAACCAAGTCATTTCTG	0.393													32	81					0	0	0	0	G	179616519	G	G	179616519	2	3	294	1	0	0	0	0	0	0	0	1	16803	59	3	5		5	TTN	2	179616519	Silent	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	18301	179616519	63582854	58	54059											
TTN	7273	broad.mit.edu	37	chr2	179632555	179632555	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagagttttgcagttgacacGttgcctcctgccaccactgt	8	12	9	12	1	0	2	0	1	0	1	1	2	1	2	4	0	3	4	4	0	1	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:179632555G>T	uc010zfg.1	-	40	9626	c.9402C>A	c.(9400-9402)AAC>AAA	p.N3134K	TTN_uc010zfh.1_Missense_Mutation_p.N3088K|TTN_uc010zfi.1_Missense_Mutation_p.N3088K|TTN_uc010zfj.1_Missense_Mutation_p.N3088K|TTN_uc002unb.2_Missense_Mutation_p.N3134K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3134							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGTTGACACGTTGCCTCCTG	0.428													35	130					9.62906e-15	1.25713e-14	1	0	T	179632555	T	T	179632555	3	4	294	1	0	0	0	0	1	0	0	0	16803	1136	40	3	101878	3	TTN	2	179632555	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	16036	179632555	63566818	59	54060											
DNAH7	56171	broad.mit.edu	37	chr2	196671535	196671535	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttatcttcccattcttcagGgaaaacctcatggtgtggtt	8	16	8	9	0	4	0	2	0	2	0	5	1	5	1	2	3	1	1	2	3	3	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:196671535G>A	uc002utj.3	-	54	10206	c.10105C>T	c.(10105-10107)CCT>TCT	p.P3369S		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3369					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CATTCTTCAGGGAAAACCTCA	0.338													13	54					0	0	0	0	A	196671535	A	A	196671535	3	1	294	1	0	0	0	0	1	0	0	0	4628	1232	43	4	2017	4	DNAH7	2	196671535	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	17038980	196671535	46527838	60	54061											
PLCL1	5334	broad.mit.edu	37	chr2	198953652	198953652	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tctgaagcagtgcctgttaaCtctgtcatctcggctcatca	8	13	8	12	1	6	1	3	1	3	0	7	1	6	1	1	1	3	3	1	1	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:198953652C>A	uc010fsp.2	+	3	3077	c.2786C>A	c.(2785-2787)ACT>AAT	p.T929N	PLCL1_uc002uuv.3_Missense_Mutation_p.T850N	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	929					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TGCCTGTTAACTCTGTCATCT	0.458													153	421					4.05767e-68	6.33355e-68	1	0	A	198953652	A	A	198953652	3	1	294	1	0	0	0	0	1	0	0	0	12094	565	20	4	2796	4	PLCL1	2	198953652	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2282117	198953652	44245721	61	54062											
MAP2	4133	broad.mit.edu	37	chr2	210557856	210557856	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagtccctttcaagggggaaGcttcactcttcctttagatg	9	13	9	10	0	3	1	2	0	1	1	5	2	5	2	2	2	1	1	2	2	4	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:210557856G>T	uc002vde.1	+	7	1210	c.962G>T	c.(961-963)AGC>ATC	p.S321I	MAP2_uc002vdc.1_Missense_Mutation_p.S321I|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.S317I	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	321					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CAAGGGGGAAGCTTCACTCTT	0.428													30	77					1.836e-18	2.538e-18	1	0	T	210557856	T	T	210557856	3	4	294	1	0	0	0	0	1	0	0	0	9288	971	34	4	976	4	MAP2	2	210557856	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	11604204	210557856	32641517	62	54063											
EPHA4	2043	broad.mit.edu	37	chr2	222322667	222322667	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagccagtgccacactgtaTcttgtgacttctttagcctg	8	13	8	12	0	2	1	0	1	2	0	2	1	2	1	3	0	3	1	3	0	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:222322667T>C	uc002vmq.2	-	6	1404	c.1362A>G	c.(1360-1362)AGA>AGG	p.R454R	EPHA4_uc002vmr.2_Silent_p.R454R|EPHA4_uc010zlm.1_Silent_p.R395R|EPHA4_uc010zln.1_Silent_p.R454R	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	454	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CCACACTGTATCTTGTGACTT	0.388													47	119					0	0	0	0	C	222322667	C	C	222322667	2	2	294	1	0	0	0	0	0	0	0	1	5193	1432	50	5		5	EPHA4	2	222322667	Silent	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	11764811	222322667	20876706	63	54064											
SLC19A3	80704	broad.mit.edu	37	chr2	228552143	228552143	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgacatgatgatattactCtcttcctctgggtgagacac	9	14	9	9	0	2	4	0	4	2	1	4	5	3	4	1	1	1	1	1	1	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:228552143C>A	uc002vpi.2	-	6	1550	c.1461G>T	c.(1459-1461)GAG>GAT	p.E487D	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.E483D	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	487	Cytoplasmic (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	TGATATTACTCTCTTCCTCTG	0.408													30	88					2.80507e-11	3.46943e-11	1	0	A	228552143	A	A	228552143	3	1	294	1	0	0	0	0	1	0	0	0	14495	912	32	2	33	2	SLC19A3	2	228552143	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	6229476	228552143	14647230	64	54065											
C2orf57	165100	broad.mit.edu	37	chr2	232458813	232458813	+	Frame_Shift_Del	DEL	C	-	-																															ctacctgaccagccacctcaCcccacgccaggcccaggctg																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:232458813delC	uc002vrz.2	+	1	1202	c.1151delC	c.(1150-1152)ACCfs	p.T384fs		NM_152614	NP_689827	Q53QW1	CB057_HUMAN	hypothetical protein LOC165100	384										ovary(1)	1		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		AGCCACCTCACCCCACGCCAG	0.652													---	---	---								-	232458813	-	-	232458813	7	5	294	1	0	1	0	1	0	0	0	0	2188	507	18	0	1153	0	C2orf57	2	232458813	Frame_Shift_Del	DEL	C	TCGA-DQ-7595-01A-11D-2229-08	3906670	232458813	10740560	65	54066											
ESPNL	339768	broad.mit.edu	37	chr2	239040215	239040215	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcgggcccctgcctcacGccgccgtcccctgcagcggc	2	6	12	21	5	1	0	1	0	0	0	3	0	2	0	7	2	4	2	7	2	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:239040215G>T	uc002vxq.3	+	9	2970	c.2860G>T	c.(2860-2862)GCC>TCC	p.A954S	ESPNL_uc010fyw.2_Missense_Mutation_p.A650S	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	954										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CCTGCCTCACGCCGCCGTCCC	0.682													7	14					0.000157383	0.000166018	1	0	T	239040215	T	T	239040215	3	4	294	1	0	0	0	0	1	0	0	0	5279	1087	38	3	2894	3	ESPNL	2	239040215	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	6581402	239040215	4159158	66	54067											
KLHL30	377007	broad.mit.edu	37	chr2	239056481	239056481	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccctcaccccacaggcaccaCcctggacgtggtggaggtgg	7	5	13	16	1	1	0	1	0	0	0	1	2	1	2	5	6	0	1	5	6	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr2:239056481C>T	uc002vxr.1	+	5	1136	c.1103C>T	c.(1102-1104)ACC>ATC	p.T368I		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	386	Kelch 3.										0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		ACAGGCACCACCCTGGACGTG	0.657													9	38					0	0	0	0	T	239056481	T	T	239056481	3	4	294	1	0	0	0	0	1	0	0	0	8423	507	18	4	1175	4	KLHL30	2	239056481	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	16266	239056481	4142892	67	54068											
NGLY1	55768	broad.mit.edu	37	chr3	25770736	25770736	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcgaacataacgatctttcAcaatattgtaacaaaggtgg	15	11	7	8	2	2	0	1	0	1	0	3	2	2	0	0	2	3	1	0	2	6	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:25770736A>C	uc003cdl.2	-	10	1607	c.1499T>G	c.(1498-1500)GTG>GGG	p.V500G	NGLY1_uc010hfg.2_Missense_Mutation_p.V482G|NGLY1_uc003cdm.2_Missense_Mutation_p.V500G|NGLY1_uc011awo.1_Missense_Mutation_p.V458G|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	500	PAW.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						ACGATCTTTCACAATATTGTA	0.323													19	36					0	0	0	0	C	25770736	C	C	25770736	3	2	294	1	0	0	0	0	1	0	0	0	10452	159	6	5	477	5	NGLY1	3	25770736	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08		25770736	172251694	68	54069											
GRM2	2912	broad.mit.edu	37	chr3	51749278	51749278	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcagccggccccctgcccGcctctcgctgcagtgagccc	3	6	10	22	3	2	1	1	1	1	0	3	1	2	1	7	1	4	2	7	1	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:51749278G>T	uc010hlv.2	+	4	1728	c.1489G>T	c.(1489-1491)GCC>TCC	p.A497S	GRM2_uc003dbo.3_5'UTR|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	497	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CCCCCTGCCCGCCTCTCGCTG	0.637													6	27					3.59834e-05	3.86319e-05	1	0	T	51749278	T	T	51749278	3	4	294	1	0	0	0	0	1	0	0	0	6836	1087	38	3	1499	3	GRM2	3	51749278	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	25978542	51749278	146273152	69	54070											
MAGI1	9223	broad.mit.edu	37	chr3	65361520	65361520	+	Frame_Shift_Del	DEL	T	-	-																															gtgatggaacatccatttacTgccaagatccggtctcctac																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:65361520delT	uc003dmn.2	-	18	3622	c.3096delA	c.(3094-3096)GCAfs	p.A1032fs	MAGI1_uc003dmm.2_Frame_Shift_Del_p.A1060fs|MAGI1_uc003dmo.2_Frame_Shift_Del_p.A1061fs|MAGI1_uc003dmp.2_Intron	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1061	PDZ 5.|Interaction with FCHSD2.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		ATCCATTTACTGCCAAGATCC	0.498													---	---	---								-	65361520	-	-	65361520	7	5	294	1	0	1	0	1	0	0	0	0	9243	1567	55	0	1459	0	MAGI1	3	65361520	Frame_Shift_Del	DEL	T	TCGA-DQ-7595-01A-11D-2229-08	13612242	65361520	132660910	70	54071											
ZPLD1	131368	broad.mit.edu	37	chr3	102189341	102189341	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgctggtcccatcattactcGgagtggtaagtgtgctcctc	6	13	11	11	1	1	0	1	0	0	0	5	1	3	1	2	3	3	3	2	3	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:102189341G>T	uc003dvs.1	+	16	1919	c.1037G>T	c.(1036-1038)CGG>CTG	p.R346L	ZPLD1_uc003dvt.1_Missense_Mutation_p.R362L|ZPLD1_uc011bhg.1_Missense_Mutation_p.R346L	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	346	Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						ATCATTACTCGGAGTGGTAAG	0.522													9	51					0.000442599	0.000459999	1	0	T	102189341	T	T	102189341	3	4	294	1	0	0	0	0	1	0	0	0	18288	1116	39	3	1119	3	ZPLD1	3	102189341	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	36827821	102189341	95833089	71	54072											
CD200	4345	broad.mit.edu	37	chr3	112064025	112064025	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagctgggactccaaaactCaaccatcaccttctggaata	13	8	6	14	0	3	0	2	0	1	0	4	2	4	2	4	2	3	1	4	2	5	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:112064025C>G	uc003dyw.2	+	4	530	c.386C>G	c.(385-387)TCA>TGA	p.S129*	CD200_uc010hqd.1_5'UTR|CD200_uc003dyx.2_Nonsense_Mutation_p.S104*|CD200_uc003dyy.2_5'UTR|CD200_uc003dyz.2_Nonsense_Mutation_p.S30*	NM_001004196	NP_001004196	P41217	OX2G_HUMAN	CD200 antigen isoform b	104	Ig-like V-type.|Extracellular (Potential).				regulation of immune response	integral to plasma membrane					0		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				CTCCAAAACTCAACCATCACC	0.493													21	121					0	0	0	0	G	112064025	G	G	112064025	4	3	294	1	0	0	0	0	0	1	0	0	2995	838	29	2	400	2	CD200	3	112064025	Nonsense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	9874684	112064025	85958405	72	54073											
ADCY5	111	broad.mit.edu	37	chr3	123047504	123047504	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcaccctgccttgccgcCagcctccatgtggttggcta	5	10	9	17	1	1	0	1	0	0	0	2	0	2	0	6	2	3	2	6	2	1	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:123047504C>A	uc003egh.1	-	6	1792	c.1792G>T	c.(1792-1794)GGC>TGC	p.G598C	ADCY5_uc003egg.1_Missense_Mutation_p.G231C|ADCY5_uc003egi.1_Missense_Mutation_p.G157C	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	598	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GCCTTGCCGCCAGCCTCCATG	0.627											OREG0015742	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	130					7.07758e-08	8.02632e-08	1	0	A	123047504	A	A	123047504	3	1	294	1	0	0	0	0	1	0	0	0	297	594	21	4	2057	4	ADCY5	3	123047504	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	10983479	123047504	74974926	73	54074											
CCDC37	348807	broad.mit.edu	37	chr3	126151975	126151975	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgatgtccatcaccaaggaGgaggacacagcagctgagct	13	6	12	10	0	1	2	1	2	0	0	2	5	2	5	2	3	3	3	2	3	1	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:126151975G>C	uc003eiu.1	+	14	1449	c.1350G>C	c.(1348-1350)GAG>GAC	p.E450D	CCDC37_uc010hsg.1_Missense_Mutation_p.E451D	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	450										ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		TCACCAAGGAGGAGGACACAG	0.587													34	214					0	0	0	0	C	126151975	C	C	126151975	3	2	294	1	0	0	0	0	1	0	0	0	2822	991	35	4	1400	4	CCDC37	3	126151975	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3104471	126151975	71870455	74	54075											
ASTE1	28990	broad.mit.edu	37	chr3	130744048	130744048	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagcaaagacggtggaaaaGagcataaccatcaatgacaa	20	4	10	7	1	1	3	1	1	0	2	1	5	1	4	1	2	3	2	1	2	7	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:130744048G>C	uc003env.1	-	3	545	c.103C>G	c.(103-105)CTT>GTT	p.L35V	NEK11_uc003enx.2_5'Flank|NEK11_uc003eny.2_5'Flank|NEK11_uc003eoa.2_5'Flank|NEK11_uc003enz.2_5'Flank|NEK11_uc010htn.2_5'Flank|NEK11_uc011blk.1_5'Flank|NEK11_uc011bll.1_5'Flank|NEK11_uc003enw.1_5'Flank|NEK11_uc011blm.1_5'Flank|ASTE1_uc010htm.1_Missense_Mutation_p.L35V|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	35					DNA repair		nuclease activity				0						CGGTGGAAAAGAGCATAACCA	0.393													45	164					0	0	0	0	C	130744048	C	C	130744048	3	2	294	1	0	0	0	0	1	0	0	0	1064	942	33	2	1952	2	ASTE1	3	130744048	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	4592073	130744048	67278382	75	54076											
KY	339855	broad.mit.edu	37	chr3	134338072	134338072	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcagtgggtttgaaggcttGgcggtccttctcctgagcag	5	12	15	9	1	2	2	1	2	1	0	4	2	3	2	2	4	1	3	2	4	1	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:134338072G>T	uc010hty.2	-	8	690	c.628C>A	c.(628-630)CAA>AAA	p.Q210K	KY_uc011blw.1_Missense_Mutation_p.Q210K|KY_uc011blx.1_Missense_Mutation_p.Q189K|KY_uc003eqr.1_5'UTR	NM_178554	NP_848649	Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	210						cytoskeleton|Z disc	peptidase activity			ovary(2)	2						TTGAAGGCTTGGCGGTCCTTC	0.557													45	114					1.61004e-24	2.38128e-24	1	0	T	134338072	T	T	134338072	3	4	294	1	0	0	0	0	1	0	0	0	8626	1357	47	4	1373	4	KY	3	134338072	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3594024	134338072	63684358	76	54077											
GK5	256356	broad.mit.edu	37	chr3	141906560	141906560	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctttaccttttgtgagcttaTataacaaccaggtatcaata	13	15	5	8	0	1	1	1	1	0	0	1	1	1	1	2	1	4	2	2	1	8	9			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:141906560T>C	uc003euq.1	-	6	736	c.605A>G	c.(604-606)TAT>TGT	p.Y202C	GK5_uc010hus.1_RNA	NM_001039547	NP_001034636	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	202					glycerol metabolic process		ATP binding|glycerol kinase activity				0						TGTGAGCTTATATAACAACCA	0.328													11	66					0	0	0	0	C	141906560	C	C	141906560	3	2	294	1	0	0	0	0	1	0	0	0	6459	1406	49	5	1028	5	GK5	3	141906560	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	7568488	141906560	56115870	77	54078											
ATR	545	broad.mit.edu	37	chr3	142188216	142188216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcatccacattgcttgttgaGgataggctagaaatactttg	11	14	9	7	0	1	2	1	1	0	1	2	3	2	3	1	2	2	3	1	2	4	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:142188216G>A	uc003eux.3	-	38	6637	c.6515C>T	c.(6514-6516)CCT>CTT	p.P2172L	ATR_uc003euy.1_Missense_Mutation_p.P58L	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2172	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TGCTTGTTGAGGATAGGCTAG	0.328								Other_conserved_DNA_damage_response_genes					27	137					0	0	0	0	A	142188216	A	A	142188216	3	1	294	1	0	0	0	0	1	0	0	0	1206	1000	35	4	1459	4	ATR	3	142188216	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	281656	142188216	55834214	78	54079											
TIPARP	25976	broad.mit.edu	37	chr3	156422631	156422631	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgctacaatgtttggacaagGcagttattttgcaaagaagg	13	12	11	5	0	0	1	0	0	0	1	0	2	0	2	0	3	3	5	0	3	6	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:156422631G>T	uc003fav.2	+	6	1933	c.1685G>T	c.(1684-1686)GGC>GTC	p.G562V	TIPARP_uc003faw.2_Missense_Mutation_p.G562V	NM_015508	NP_056323	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	562	PARP catalytic.						NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|breast(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TTTGGACAAGGCAGTTATTTT	0.438													49	263					6.38213e-41	9.81688e-41	1	0	T	156422631	T	T	156422631	3	4	294	1	0	0	0	0	1	0	0	0	15990	1203	42	4	1703	4	TIPARP	3	156422631	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	14234415	156422631	41599799	79	54080											
SLITRK3	22865	broad.mit.edu	37	chr3	164906145	164906145	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcactatggtgttaagctggGagctggacactgctagggcc	8	10	14	9	0	1	0	1	0	0	0	1	2	1	2	1	4	3	4	1	4	3	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:164906145G>T	uc003fej.3	-	2	2918	c.2474C>A	c.(2473-2475)TCC>TAC	p.S825Y	SLITRK3_uc003fek.2_Missense_Mutation_p.S825Y	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	825	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GTTAAGCTGGGAGCTGGACAC	0.542										HNSCC(40;0.11)			43	169					9.84934e-19	1.37048e-18	1	0	T	164906145	T	T	164906145	3	4	294	1	0	0	0	0	1	0	0	0	14808	1174	41	2	463	2	SLITRK3	3	164906145	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	8483514	164906145	33116285	80	54081											
SAMD7	344658	broad.mit.edu	37	chr3	169644505	169644505	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccctgccggtgacctgcattTtcacagaagcaccctcagaa	10	8	8	15	1	2	3	2	1	0	2	2	3	2	3	4	1	3	2	4	1	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:169644505T>A	uc003fgd.2	+	6	722	c.455T>A	c.(454-456)TTT>TAT	p.F152Y	SAMD7_uc003fge.2_Missense_Mutation_p.F152Y|SAMD7_uc011bpo.1_Missense_Mutation_p.F53Y	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	152										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GACCTGCATTTTCACAGAAGC	0.597													54	79					0	0	0	0	A	169644505	A	A	169644505	3	1	294	1	0	0	0	0	1	0	0	0	13889	1841	64	5	469	5	SAMD7	3	169644505	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	4738360	169644505	28377925	81	54082											
CCDC39	339829	broad.mit.edu	37	chr3	180372582	180372582	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgaattctactagtttcatGgtcctgatatgccgttctac	8	16	7	10	1	3	2	1	2	2	0	4	2	4	2	2	1	3	2	2	1	5	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:180372582G>T	uc010hxe.2	-	7	1013	c.898C>A	c.(898-900)CAT>AAT	p.H300N	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	300					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CTAGTTTCATGGTCCTGATAT	0.348													14	39					4.14922e-12	5.17734e-12	1	0	T	180372582	T	T	180372582	3	4	294	1	0	0	0	0	1	0	0	0	2824	1348	47	4	1983	4	CCDC39	3	180372582	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	10728077	180372582	17649848	82	54083											
CHRD	8646	broad.mit.edu	37	chr3	184105203	184105203	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagctggcgggcagcgggtAcgcggtggcaccccgttgtg	4	6	20	11	5	0	0	0	0	0	0	0	1	0	1	2	6	3	5	2	6	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr3:184105203A>G	uc003fov.2	+	19	2635	c.2389A>G	c.(2389-2391)ACG>GCG	p.T797A	CHRD_uc003fow.2_Missense_Mutation_p.T427A|CHRD_uc003fox.2_Missense_Mutation_p.T797A|CHRD_uc003foy.2_Missense_Mutation_p.T427A|CHRD_uc010hyc.2_Missense_Mutation_p.T387A|CHRD_uc011brr.1_Missense_Mutation_p.T339A	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	797	VWFC 3.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGCAGCGGGTACGCGGTGGCA	0.597													31	42					0	0	0	0	G	184105203	G	G	184105203	3	3	294	1	0	0	0	0	1	0	0	0	3387	391	14	5	2463	5	CHRD	3	184105203	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	3732621	184105203	13917227	83	54084											
KIT	3815	broad.mit.edu	37	chr4	55604672	55604672	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgtgcggatcaattctgtCggcagcaccgcttcctcctc	5	12	9	15	3	3	0	1	0	2	0	7	1	5	1	3	2	2	3	3	2	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:55604672C>A	uc010igr.2	+	21	2967	c.2880C>A	c.(2878-2880)GTC>GTA	p.V960V	KIT_uc010igs.2_Silent_p.V956V	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	960	Cytoplasmic (Potential).				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TCAATTCTGTCGGCAGCACCG	0.527		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				38	117					5.43694e-19	7.61531e-19	1	0	A	55604672	A	A	55604672	2	1	294	1	0	0	0	0	0	0	0	1	8368	871	31	3		3	KIT	4	55604672	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08		55604672	135549604	84	54085											
EXOC1	55763	broad.mit.edu	37	chr4	56734585	56734585	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accaagagttaaatgcaagaGaagaacaggatatcgaaata	21	6	9	5	1	0	3	0	0	0	3	1	6	0	4	1	1	2	2	1	1	9	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:56734585G>A	uc003hbe.1	+	5	657	c.499G>A	c.(499-501)GAA>AAA	p.E167K	EXOC1_uc003hbf.1_Missense_Mutation_p.E167K|EXOC1_uc003hbg.1_Missense_Mutation_p.E167K	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	167	Potential.				exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					AAATGCAAGAGAAGAACAGGA	0.398													15	53					0	0	0	0	A	56734585	A	A	56734585	3	1	294	1	0	0	0	0	1	0	0	0	5325	943	33	2	513	2	EXOC1	4	56734585	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1129913	56734585	134419691	85	54086											
LPHN3	23284	broad.mit.edu	37	chr4	62849144	62849144	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgttacatttcttcttctTggctgccttcacctggatgt	4	18	7	12	0	4	0	1	0	3	0	4	1	4	1	3	2	2	2	3	2	1	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:62849144T>C	uc010ihh.2	+	16	3028	c.2855T>C	c.(2854-2856)TTG>TCG	p.L952S	LPHN3_uc003hcq.3_Missense_Mutation_p.L952S|LPHN3_uc003hct.2_Missense_Mutation_p.L345S	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	939	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TTCTTCTTCTTGGCTGCCTTC	0.433													11	31					0	0	0	0	C	62849144	C	C	62849144	3	2	294	1	0	0	0	0	1	0	0	0	8967	1821	63	5	2917	5	LPHN3	4	62849144	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	6114559	62849144	128305132	86	54087											
ENAM	10117	broad.mit.edu	37	chr4	71500050	71500050	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acacctggggcccttctttgGaaacggtctccctcagcaat	8	10	9	14	1	3	0	1	0	2	0	4	1	3	1	3	4	2	1	3	4	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:71500050G>A	uc011caw.1	+	6	517	c.236G>A	c.(235-237)GGA>GAA	p.G79E		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	79					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			CCCTTCTTTGGAAACGGTCTC	0.507													65	209					0	0	0	0	A	71500050	A	A	71500050	3	1	294	1	0	0	0	0	1	0	0	0	5136	1174	41	2	254	2	ENAM	4	71500050	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	8650906	71500050	119654226	87	54088											
SEC31A	22872	broad.mit.edu	37	chr4	83776146	83776146	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagatcacaagactcaacaaTctctttccagttcttcatca	14	12	3	12	0	6	2	4	0	2	2	8	2	7	2	1	0	1	1	1	0	4	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:83776146T>C	uc003hnf.2	-	17	2082	c.1918A>G	c.(1918-1920)ATT>GTT	p.I640V	SEC31A_uc003hne.2_Missense_Mutation_p.I373V|SEC31A_uc011ccl.1_Missense_Mutation_p.I601V|SEC31A_uc003hnl.2_Missense_Mutation_p.I601V|SEC31A_uc003hng.2_Missense_Mutation_p.I640V|SEC31A_uc003hnh.2_Missense_Mutation_p.I640V|SEC31A_uc003hni.2_Missense_Mutation_p.I640V|SEC31A_uc003hnj.2_Missense_Mutation_p.I601V|SEC31A_uc011ccm.1_Missense_Mutation_p.I635V|SEC31A_uc011ccn.1_Missense_Mutation_p.I640V|SEC31A_uc003hnk.2_Missense_Mutation_p.I601V|SEC31A_uc003hnm.2_Missense_Mutation_p.I640V|SEC31A_uc003hnn.1_Missense_Mutation_p.I640V	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	640					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				GACTCAACAATCTCTTTCCAG	0.363													13	37					0	0	0	0	C	83776146	C	C	83776146	3	2	294	1	0	0	0	0	1	0	0	0	14063	1435	50	5	1788	5	SEC31A	4	83776146	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	12276096	83776146	107378130	88	54089											
NAP1L5	266812	broad.mit.edu	37	chr4	89618395	89618395	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aggcatctcggcgtgggcatCgtcatgtttggcccccgcgg	4	9	15	13	5	2	0	1	0	1	0	4	0	2	0	2	5	0	3	2	5	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:89618395C>G	uc003hrx.2	-	1	629	c.511G>C	c.(511-513)GAT>CAT	p.D171H	HERC3_uc003hrw.1_Intron|HERC3_uc011cdn.1_Intron|HERC3_uc011cdo.1_Intron	NM_153757	NP_715638	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	171					nucleosome assembly	nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		GCGTGGGCATCGTCATGTTTG	0.383													37	144					0	0	0	0	G	89618395	G	G	89618395	3	3	294	1	0	0	0	0	1	0	0	0	10213	884	31	3	41	3	NAP1L5	4	89618395	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	5842249	89618395	101535881	89	54090											
UNC5C	8633	broad.mit.edu	37	chr4	96469888	96469888	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggcggacccccttaccttGggcggcggagccagtgccgc	4	7	15	15	4	0	0	0	0	0	0	0	2	0	2	5	5	3	0	5	5	1	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:96469888G>C	uc003htp.1	-	1	275	c.121C>G	c.(121-123)CAA>GAA	p.Q41E	UNC5C_uc010ilc.1_Missense_Mutation_p.Q41E|UNC5C_uc003htq.2_Missense_Mutation_p.Q41E	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	41	Extracellular (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CCCTTACCTTGGGCGGCGGAG	0.517													11	25					0	0	0	0	C	96469888	C	C	96469888	3	2	294	1	0	0	0	0	1	0	0	0	17061	1357	47	4	2738	4	UNC5C	4	96469888	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	6851493	96469888	94684388	90	54091											
RAP1GDS1	5910	broad.mit.edu	37	chr4	99342515	99342515	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggagtcaaacagactgctGtctgcccttatacgacacag	11	8	11	11	1	2	1	1	0	1	1	2	3	2	2	1	2	4	1	1	2	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:99342515G>C	uc003htx.3	+	12	1600	c.1410G>C	c.(1408-1410)CTG>CTC	p.L470L	RAP1GDS1_uc003htw.3_Silent_p.L471L|RAP1GDS1_uc003htv.3_Silent_p.L470L|RAP1GDS1_uc003htz.3_Silent_p.L421L|RAP1GDS1_uc003hty.3_Silent_p.L422L|RAP1GDS1_uc003hua.3_Silent_p.L379L	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	470							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		ACAGACTGCTGTCTGCCCTTA	0.428			T	NUP98	T-ALL								8	40					0	0	0	0	C	99342515	C	C	99342515	2	2	294	1	0	0	0	0	0	0	0	1	13104	1364	48	4		4	RAP1GDS1	4	99342515	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2872627	99342515	91811761	91	54092											
ARHGEF38	54848	broad.mit.edu	37	chr4	106473961	106473961	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgggaaagaaaacatggtCaccaagaaaaagaatctggc	19	5	10	7	0	2	3	1	0	1	3	2	4	2	4	1	3	1	0	1	3	7	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:106473961C>A	uc003hxu.2	+	1	185	c.39C>A	c.(37-39)GTC>GTA	p.V13V		NM_017700	NP_060170	Q9NXL2	ARH38_HUMAN	hypothetical protein LOC54848	13					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|breast(1)	3						AAAACATGGTCACCAAGAAAA	0.488													13	35					6.72482e-11	8.22139e-11	1	0	A	106473961	A	A	106473961	2	1	294	1	0	0	0	0	0	0	0	1	907	813	29	2		2	ARHGEF38	4	106473961	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	7131446	106473961	84680315	92	54093											
INTS12	57117	broad.mit.edu	37	chr4	106604042	106604042	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttgctggtagtacttccacTaggtcctgatgttccactat	7	16	8	10	0	0	1	0	1	0	0	3	1	3	1	3	2	2	4	3	2	4	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:106604042T>G	uc003hxw.2	-	8	1495	c.1237A>C	c.(1237-1239)AGT>CGT	p.S413R	INTS12_uc010ilr.2_Missense_Mutation_p.S413R	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	413	Ser-rich.				snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		GTACTTCCACTAGGTCCTGAT	0.453													39	120					0	0	0	0	G	106604042	G	G	106604042	3	3	294	1	0	0	0	0	1	0	0	0	7816	1522	53	5	155	5	INTS12	4	106604042	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	130081	106604042	84550234	93	54094											
CYP2U1	113612	broad.mit.edu	37	chr4	108868684	108868684	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccattcctcatatgacctcaGagaacacaggcaagtccagg	13	7	8	13	0	2	2	2	1	0	1	4	3	4	2	4	2	1	1	4	2	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:108868684G>A	uc003hyp.2	+	3	1362	c.1279G>A	c.(1279-1281)GAG>AAG	p.E427K	CYP2U1_uc011cfi.1_Missense_Mutation_p.E218K	NM_183075	NP_898898	Q7Z449	CP2U1_HUMAN	cytochrome P450, family 2, subfamily U,	427					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000128)		TATGACCTCAGAGAACACAGG	0.552													7	36					0	0	0	0	A	108868684	A	A	108868684	3	1	294	1	0	0	0	0	1	0	0	0	4192	943	33	2	1289	2	CYP2U1	4	108868684	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2264642	108868684	82285592	94	54095											
PRDM5	11107	broad.mit.edu	37	chr4	121719573	121719573	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatctcgcaattatagggtCgtttttctattaaaaaaatg	15	15	6	5	2	2	0	0	0	2	0	4	0	2	0	0	1	0	2	0	1	9	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:121719573C>A	uc003idn.2	-	10	1287	c.1037G>T	c.(1036-1038)CGA>CTA	p.R346L	PRDM5_uc003ido.2_Missense_Mutation_p.R315L|PRDM5_uc010ine.2_Missense_Mutation_p.R315L	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	346					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						ATTATAGGGTCGTTTTTCTAT	0.333													15	40					1.67942e-08	1.94628e-08	1	0	A	121719573	A	A	121719573	3	1	294	1	0	0	0	0	1	0	0	0	12522	884	31	3	883	3	PRDM5	4	121719573	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	12850889	121719573	69434703	95	54096											
C4orf31	79625	broad.mit.edu	37	chr4	121958675	121958675	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtgtctttctctgttgaaaGaagatccaactgatataaac	13	14	7	7	0	2	4	0	2	2	2	4	4	3	4	1	0	2	1	1	0	6	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:121958675G>C	uc003idq.1	-	4	978	c.451C>G	c.(451-453)CTT>GTT	p.L151V		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	151											0						TCTGTTGAAAGAAGATCCAAC	0.403													35	116					0	0	0	0	C	121958675	C	C	121958675	3	2	294	1	0	0	0	0	1	0	0	0	2271	942	33	2	1259	2	C4orf31	4	121958675	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	239102	121958675	69195601	96	54097											
PCDH10	57575	broad.mit.edu	37	chr4	134072303	134072303	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccaaggacctgggccccaaCgccgtgcctgcgcactgcaa	8	4	12	17	3	0	0	0	0	0	0	0	1	0	1	6	2	4	2	6	2	3	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:134072303C>A	uc003iha.2	+	1	1834	c.1008C>A	c.(1006-1008)AAC>AAA	p.N336K	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.N336K	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	336	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TGGGCCCCAACGCCGTGCCTG	0.597													29	116					2.49991e-28	3.73662e-28	1	0	A	134072303	A	A	134072303	3	1	294	1	0	0	0	0	1	0	0	0	11561	535	19	3	1010	3	PCDH10	4	134072303	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	12113628	134072303	57081973	97	54098											
DCHS2	54798	broad.mit.edu	37	chr4	155156292	155156293	+	Frame_Shift_Ins	INS	-	C	C																															acaggtggtgctgcagccttINSccccttgatctccttcccca																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:155156292_155156293insC	uc003inw.2	-	25	8146_8147	c.8146_8147insG	c.(8146-8148)GAAfs	p.E2716fs		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2716					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GCTGCAGCCTTCCCCTTGATCT	0.51													---	---	---								C	155156293	C	C	155156292	7	5	294	1	0	1	1	0	0	0	0	0	4305	1783	62	0	607	0	DCHS2	4	155156292	Frame_Shift_Ins	INS	-	TCGA-DQ-7595-01A-11D-2229-08	21083989	155156292	35997984	98	54099											
DCHS2	54798	broad.mit.edu	37	chr4	155249306	155249306	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaggatcctttgcaaacacAgttgtaaccaacatatttac	14	12	5	10	0	1	0	1	0	0	0	2	1	2	1	2	1	5	3	2	1	5	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:155249306A>G	uc003inw.2	-	12	2592	c.2592T>C	c.(2590-2592)ACT>ACC	p.T864T	DCHS2_uc003inx.2_Silent_p.T1319T	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	864	Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTGCAAACACAGTTGTAACCA	0.353													25	104					0	0	0	0	G	155249306	G	G	155249306	2	3	294	1	0	0	0	0	0	0	0	1	4305	175	7	5		5	DCHS2	4	155249306	Silent	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	93014	155249306	35904970	99	54100											
FSTL5	56884	broad.mit.edu	37	chr4	162307065	162307065	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgcctgtttttccggttcCaaggccattcttctgccttg	3	18	8	12	1	2	0	0	0	2	0	4	0	4	0	5	2	2	2	5	2	1	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:162307065C>A	uc003iqh.2	-	16	2814	c.2378G>T	c.(2377-2379)TGG>TTG	p.W793L	FSTL5_uc003iqi.2_Missense_Mutation_p.W792L|FSTL5_uc010iqv.2_Missense_Mutation_p.W783L|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	793						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTTCCGGTTCCAAGGCCATTC	0.468													34	141					5.04308e-16	6.70825e-16	1	0	A	162307065	A	A	162307065	3	1	294	1	0	0	0	0	1	0	0	0	6114	595	21	4	169	4	FSTL5	4	162307065	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	7057759	162307065	28847211	100	54101											
ODZ3	55714	broad.mit.edu	37	chr4	183652084	183652084	+	Frame_Shift_Del	DEL	C	-	-																															aactttggtatttgaacgatCcccattcctcactcagtatc																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:183652084delC	uc003ivd.1	+	15	2796	c.2759delC	c.(2758-2760)TCCfs	p.S920fs	ODZ3_uc003ive.1_Frame_Shift_Del_p.S326fs	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	920	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TTTGAACGATCCCCATTCCTC	0.418													---	---	---								-	183652084	-	-	183652084	7	5	294	1	0	1	0	1	0	0	0	0	10890	855	30	0	2817	0	ODZ3	4	183652084	Frame_Shift_Del	DEL	C	TCGA-DQ-7595-01A-11D-2229-08	21345019	183652084	7502192	101	54102											
ODZ3	55714	broad.mit.edu	37	chr4	183721323	183721323	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgcgcgagcagcagcgcgTgcgcgacggcgaggagggcg	6	1	22	12	10	0	0	0	0	0	0	0	4	0	1	0	4	4	2	0	4	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:183721323T>A	uc003ivd.1	+	27	7956	c.7919T>A	c.(7918-7920)GTG>GAG	p.V2640E		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2640	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CAGCAGCGCGTGCGCGACGGC	0.741													5	16					0	0	0	0	A	183721323	A	A	183721323	3	1	294	1	0	0	0	0	1	0	0	0	10890	1696	59	5	8025	5	ODZ3	4	183721323	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	69239	183721323	7432953	102	54103											
FAT1	2195	broad.mit.edu	37	chr4	187540161	187540161	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atttacaatatggtaagtaaCgtgaccataaataccagaat	18	11	6	6	1	0	2	0	1	0	1	0	2	0	2	2	1	3	2	2	1	9	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:187540161C>T	uc003izf.2	-	10	7767	c.7579G>A	c.(7579-7581)GTT>ATT	p.V2527I		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2527	Extracellular (Potential).|Cadherin 23.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGGTAAGTAACGTGACCATAA	0.408										HNSCC(5;0.00058)			44	124					0	0	0	0	T	187540161	T	T	187540161	3	4	294	1	0	0	0	0	1	0	0	0	5721	536	19	1	6259	1	FAT1	4	187540161	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3818838	187540161	3614115	103	54104											
FRG1	2483	broad.mit.edu	37	chr4	190882995	190882995	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agaaagaaatttcagagcttCcaagaccacaaacttaaaat	20	8	5	8	0	1	4	1	0	0	4	2	4	2	4	2	0	2	1	2	0	6	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr4:190882995C>A	uc003izs.2	+	8	839	c.648C>A	c.(646-648)TTC>TTA	p.F216L		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	216					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		TTCAGAGCTTCCAAGACCACA	0.294													24	83					4.06085e-26	6.02716e-26	1	0	A	190882995	A	A	190882995	3	1	294	1	0	0	0	0	1	0	0	0	6080	854	30	2	678	2	FRG1	4	190882995	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3342834	190882995	271281	104	54105											
LPCAT1	79888	broad.mit.edu	37	chr5	1489905	1489907	+	In_Frame_Del	DEL	CTA	-	-																															cgcccgtctcttgatttcttCtactgttttcctgcgagaat																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:1489905_1489907delCTA	uc003jcm.2	-	4	677_679	c.560_562delTAG	c.(559-564)GTAGAA>GAA	p.V187del		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	187	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		TTGATTTCTTCTACTGTTTTCCT	0.512													---	---	---								-	1489907	-	-	1489905	7	5	294	1	0	1	0	1	0	0	0	0	8960	922	32	0	1086	0	LPCAT1	5	1489905	In_Frame_Del	DEL	CTA	TCGA-DQ-7595-01A-11D-2229-08		1489905	179425355	105	54106											
SEMA5A	9037	broad.mit.edu	37	chr5	9052111	9052111	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacgccagaggcttcacactCagaccagtccgaccactccg	10	5	9	17	3	2	2	2	0	0	2	4	4	4	2	5	1	0	1	5	1	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:9052111C>G	uc003jek.2	-	20	3431	c.2719G>C	c.(2719-2721)GAG>CAG	p.E907Q		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	907	Extracellular (Potential).|TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GCTTCACACTCAGACCAGTCC	0.622													5	23					0	0	0	0	G	9052111	G	G	9052111	3	3	294	1	0	0	0	0	1	0	0	0	14102	835	29	2	521	2	SEMA5A	5	9052111	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	7562206	9052111	171863149	106	54107											
TRIO	7204	broad.mit.edu	37	chr5	14508202	14508202	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catacgtacttcttagtggcGtgtcccccttcctggatgac	6	13	9	13	2	1	1	0	1	1	0	3	2	3	2	3	2	2	1	3	2	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:14508202G>A	uc003jff.2	+	57	8971	c.8965G>A	c.(8965-8967)GTG>ATG	p.V2989M	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2989	Protein kinase.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCTTAGTGGCGTGTCCCCCTT	0.522													21	77					0	0	0	0	A	14508202	A	A	14508202	3	1	294	1	0	0	0	0	1	0	0	0	16619	1145	40	1	9191	1	TRIO	5	14508202	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	5456091	14508202	166407058	107	54108											
CDH18	1016	broad.mit.edu	37	chr5	19473641	19473641	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttcacttcaggtctgatatcCctccggtacttgagctcctc	6	14	7	14	1	3	2	2	2	1	0	7	2	6	2	3	2	2	2	3	2	2	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:19473641C>T	uc003jgc.2	-	12	2444	c.2067G>A	c.(2065-2067)AGG>AGA	p.R689R	CDH18_uc003jgd.2_Silent_p.R689R|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	689	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GTCTGATATCCCTCCGGTACT	0.493													21	56					0	0	0	0	T	19473641	T	T	19473641	2	4	294	1	0	0	0	0	0	0	0	1	3118	622	22	4		4	CDH18	5	19473641	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	4965439	19473641	161441619	108	54109											
CDH10	1008	broad.mit.edu	37	chr5	24505236	24505236	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttactgatttcagcagcaaTaacagtaagattatgccact	14	12	6	9	0	1	2	1	1	0	1	1	2	1	2	1	0	5	3	1	0	5	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:24505236T>C	uc003jgr.1	-	8	1710	c.1378A>G	c.(1378-1380)ATT>GTT	p.I460V	CDH10_uc011cnu.1_Intron	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	460	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCAGCAGCAATAACAGTAAGA	0.289										HNSCC(23;0.051)			17	56					0	0	0	0	C	24505236	C	C	24505236	3	2	294	1	0	0	0	0	1	0	0	0	3111	1406	49	5	1008	5	CDH10	5	24505236	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	5031595	24505236	156410024	109	54110											
SERINC5	256987	broad.mit.edu	37	chr5	79462247	79462247	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acagagctgagaaggtgaggTaggtgacatagcagcttatg	13	8	15	5	0	0	4	0	3	0	2	0	5	0	4	0	3	3	4	0	3	4	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:79462247T>G	uc003kgj.2	-	7	947	c.818A>C	c.(817-819)TAC>TCC	p.Y273S	SERINC5_uc003kgk.2_Missense_Mutation_p.Y273S|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.Y273S|SERINC5_uc011ctj.1_Missense_Mutation_p.Y273S	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	273	Helical; (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GAAGGTGAGGTAGGTGACATA	0.463													4	6					0	0	0	0	G	79462247	G	G	79462247	3	3	294	1	0	0	0	0	1	0	0	0	14148	1638	57	5	629	5	SERINC5	5	79462247	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	54957011	79462247	101453013	110	54111											
EPB41L4A	64097	broad.mit.edu	37	chr5	111519828	111519828	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaccatatcattctcctgccGtattctgaaaggaaagccat	13	11	6	11	1	3	1	1	1	2	0	4	2	3	2	4	1	3	1	4	1	5	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:111519828G>A	uc003kpv.1	-	18	1781	c.1507C>T	c.(1507-1509)CGG>TGG	p.R503W	EPB41L4A_uc003kpp.1_Missense_Mutation_p.R130W	NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	503						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TTCTCCTGCCGTATTCTGAAA	0.433													18	43					0	0	0	0	A	111519828	A	A	111519828	3	1	294	1	0	0	0	0	1	0	0	0	5179	1144	40	1	577	1	EPB41L4A	5	111519828	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	32057581	111519828	69395432	111	54112											
AQPEP	206338	broad.mit.edu	37	chr5	115298441	115298441	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtacggccactgcgagcgcGtcccaccgtcggagctgcct	5	7	13	16	6	0	0	0	0	0	0	2	2	1	1	4	2	5	2	4	2	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:115298441G>C	uc003kro.2	+	1	291	c.127G>C	c.(127-129)GTC>CTC	p.V43L	AQPEP_uc003krp.2_RNA|uc003krn.1_5'UTR	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	43	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						CTGCGAGCGCGTCCCACCGTC	0.692													5	22					0	0	0	0	C	115298441	C	C	115298441	3	2	294	1	0	0	0	0	1	0	0	0	834	1145	40	3	129	3	AQPEP	5	115298441	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3778613	115298441	65616819	112	54113											
FAM53C	51307	broad.mit.edu	37	chr5	137680781	137680781	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcgctggcagccggtgtggcGgcccgccccctccaagctgt	3	7	14	17	4	0	0	0	0	0	0	2	0	1	0	5	4	2	3	5	4	1	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:137680781G>T	uc003lcv.2	+	4	874	c.404G>T	c.(403-405)CGG>CTG	p.R135L	FAM53C_uc003lcw.2_Missense_Mutation_p.R135L|FAM53C_uc011cyq.1_Intron|FAM53C_uc011cyr.1_Intron	NM_001135647	NP_001129119	Q9NYF3	FA53C_HUMAN	hypothetical protein LOC51307	135										ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCGGTGTGGCGGCCCGCCCCC	0.687													32	82					4.14481e-20	5.92316e-20	1	0	T	137680781	T	T	137680781	3	4	294	1	0	0	0	0	1	0	0	0	5613	1116	39	3	414	3	FAM53C	5	137680781	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	22382340	137680781	43234479	113	54114											
PCDHA6	56142	broad.mit.edu	37	chr5	140209111	140209111	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacatcttcacggtgtctGcgcgagacgcggacgcgcag	7	6	14	14	7	3	1	1	0	2	1	3	3	3	2	1	2	1	1	1	2	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:140209111G>T	uc003lho.2	+	1	1462	c.1435G>T	c.(1435-1437)GCG>TCG	p.A479S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.A479S|PCDHA6_uc011dab.1_Missense_Mutation_p.A479S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	479	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGTGTCTGCGCGAGACGC	0.652													37	93					6.2361e-21	9.00298e-21	1	0	T	140209111	T	T	140209111	3	4	294	1	0	0	0	0	1	0	0	0	11582	1319	46	4	1437	4	PCDHA6	5	140209111	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2528330	140209111	40706149	114	54115											
PCDHAC1	56135	broad.mit.edu	37	chr5	140308211	140308212	+	Frame_Shift_Ins	INS	-	T	T																															gctctgccaggactggacacINSttggtcacaaaagtggtagc																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:140308211_140308212insT	uc003lih.2	+	1	1910_1911	c.1734_1735insT	c.(1732-1737)CACTTGfs	p.H578fs	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Frame_Shift_Ins_p.H578fs	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	578_579	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACTGGACACTTGGTCACAAA	0.49													---	---	---								T	140308212	T	T	140308211	7	5	294	1	0	1	1	0	0	0	0	0	11586	564	20	0	1736	0	PCDHAC1	5	140308211	Frame_Shift_Ins	INS	-	TCGA-DQ-7595-01A-11D-2229-08	99100	140308211	40607049	115	54116											
PCDHGA6	56109	broad.mit.edu	37	chr5	140755535	140755536	+	Frame_Shift_Del	DEL	GC	-	-																															acacgggcgaggtgcgcacgGcgcgcgccctgctggacaga																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:140755535_140755536delGC	uc003ljy.1	+	1	1885_1886	c.1885_1886delGC	c.(1885-1887)GCGfs	p.A629fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Frame_Shift_Del_p.A629fs	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	629	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCGCACGGCGCGCGCCCTG	0.688													---	---	---								-	140755536	-	-	140755535	7	5	294	1	0	1	0	1	0	0	0	0	11612	1203	42	0	1887	0	PCDHGA6	5	140755535	Frame_Shift_Del	DEL	GC	TCGA-DQ-7595-01A-11D-2229-08	447324	140755535	40159725	116	54117											
PCDHGA8	9708	broad.mit.edu	37	chr5	140772655	140772655	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccgcgggcaggatagatcGggaggagctctgcgctcaga	9	5	16	11	4	2	2	1	0	1	2	3	5	2	5	1	4	2	3	1	4	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:140772655G>T	uc003lkd.1	+	1	1173	c.275G>T	c.(274-276)CGG>CTG	p.R92L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.R92L	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGATAGATCGGGAGGAGCTC	0.532													13	30					4.36969e-10	5.22141e-10	1	0	T	140772655	T	T	140772655	3	4	294	1	0	0	0	0	1	0	0	0	11614	1116	39	3	277	3	PCDHGA8	5	140772655	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	17120	140772655	40142605	117	54118											
CYFIP2	26999	broad.mit.edu	37	chr5	156816422	156816422	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcatccctgtgggaaccaacGagttcacagctgagtgagta	11	8	12	10	1	1	2	1	2	0	0	2	4	2	3	2	1	3	4	2	1	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:156816422G>A	uc003lwq.2	+	31	3571	c.3433G>A	c.(3433-3435)GAG>AAG	p.E1145K	CYFIP2_uc011ddn.1_Missense_Mutation_p.E1119K|CYFIP2_uc011ddo.1_Missense_Mutation_p.E949K|CYFIP2_uc003lwr.2_Missense_Mutation_p.E1145K|CYFIP2_uc003lws.2_Missense_Mutation_p.E1145K|CYFIP2_uc003lwt.2_Missense_Mutation_p.E1048K|CYFIP2_uc011ddp.1_Missense_Mutation_p.E879K|CYFIP2_uc003lwv.2_Missense_Mutation_p.E100K	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1170					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGGAACCAACGAGTTCACAGC	0.597													10	25					0	0	0	0	A	156816422	A	A	156816422	3	1	294	1	0	0	0	0	1	0	0	0	4155	1059	37	1	3543	1	CYFIP2	5	156816422	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	16043767	156816422	24098838	118	54119											
ATP10B	23120	broad.mit.edu	37	chr5	160061553	160061553	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gtcaaggtcattgctcaagaAgaacacttgcccgagcttca	12	9	9	11	1	4	2	4	0	0	2	4	3	4	2	1	1	4	2	1	1	4	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:160061553A>G	uc003lym.1	-	12	2036	c.1189T>C	c.(1189-1191)TTC>CTC	p.F397L	ATP10B_uc003lyp.2_Missense_Mutation_p.F397L|ATP10B_uc011deg.1_Missense_Mutation_p.F441L|ATP10B_uc003lyn.2_5'UTR|ATP10B_uc003lyo.2_Missense_Mutation_p.F369L	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	397	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGCTCAAGAAGAACACTTGC	0.473													13	33					0	0	0	0	G	160061553	G	G	160061553	3	3	294	1	0	0	0	0	1	0	0	0	1119	72	3	5	3256	5	ATP10B	5	160061553	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	3245131	160061553	20853707	119	54120											
NSD1	64324	broad.mit.edu	37	chr5	176637807	176637807	+	Frame_Shift_Del	DEL	C	-	-																															aaaatccagttatggcagaaCccccagttataaatgaggag																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr5:176637807delC	uc003mfr.3	+	5	2545	c.2407delC	c.(2407-2409)CCCfs	p.P803fs	NSD1_uc003mft.3_Frame_Shift_Del_p.P534fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.P700fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.P451fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	803					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TATGGCAGAACCCCCAGTTAT	0.438			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---								-	176637807	-	-	176637807	7	5	294	1	0	1	0	1	0	0	0	0	10723	507	18	0	2421	0	NSD1	5	176637807	Frame_Shift_Del	DEL	C	TCGA-DQ-7595-01A-11D-2229-08	16576254	176637807	4277453	120	54121											
HFE	3077	broad.mit.edu	37	chr6	26091192	26091192	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatgatcatgagagtcgccGtgtggagccccgaactccat	9	9	11	12	3	1	2	1	2	0	1	3	5	2	3	4	1	2	0	4	1	2	1	rs139523708		TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:26091192G>T	uc003nfx.1	+	2	360	c.200G>T	c.(199-201)CGT>CTT	p.R67L	HFE_uc003nfy.1_Missense_Mutation_p.R44L|HFE_uc010jqe.1_Missense_Mutation_p.R67L|HFE_uc003nfz.1_Intron|HFE_uc003ngd.1_Intron|HFE_uc003nga.1_Missense_Mutation_p.R67L|HFE_uc003ngb.1_Missense_Mutation_p.R67L|HFE_uc003ngc.1_Missense_Mutation_p.R67L|HFE_uc003nge.1_Intron|HFE_uc003ngf.1_Intron	NM_000410	NP_000401	Q30201	HFE_HUMAN	hemochromatosis protein isoform 1 precursor	67	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|cellular iron ion homeostasis|immune response|iron ion transport|protein complex assembly|receptor-mediated endocytosis	apical part of cell|basal part of cell|cytoplasmic vesicle|early endosome|integral to plasma membrane|MHC class I protein complex|perinuclear region of cytoplasm|recycling endosome	protein binding				0						GAGAGTCGCCGTGTGGAGCCC	0.512									Hemochromatosis				18	58					1.2644e-06	1.3856e-06	1	0	T	26091192	T	T	26091192	3	4	294	1	0	0	0	0	1	0	0	0	7120	1145	40	3	206	3	HFE	6	26091192	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08		26091192	145023875	121	54122											
ZNF192	7745	broad.mit.edu	37	chr6	28121669	28121669	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actggtctcattcaacacctGagaattcacacaggggagaa	14	8	9	10	0	3	2	3	1	1	2	4	4	3	2	1	3	1	0	1	3	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:28121669G>C	uc003nkn.1	+	6	1795	c.1611G>C	c.(1609-1611)CTG>CTC	p.L537L	ZNF192_uc010jqx.1_Silent_p.L537L|ZNF192_uc010jqy.1_Silent_p.L350L|ZNF192_uc011dkz.1_Silent_p.L350L	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	537	C2H2-type 8.				viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTCAACACCTGAGAATTCACA	0.438													18	48					0	0	0	0	C	28121669	C	C	28121669	2	2	294	1	0	0	0	0	0	0	0	1	17823	1277	45	2		2	ZNF192	6	28121669	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2030477	28121669	142993398	122	54123											
OR2H2	7932	broad.mit.edu	37	chr6	29556485	29556485	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttctacagctcagtcattgCtgtctacctccagcccaaaa	10	11	5	15	0	4	0	2	0	2	0	5	0	5	0	3	0	5	2	3	0	4	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:29556485C>A	uc003nmr.1	+	1	803	c.764C>A	c.(763-765)GCT>GAT	p.A255D	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	255	Helical; Name=6; (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCAGTCATTGCTGTCTACCTC	0.512													14	51					3.62473e-10	4.38075e-10	1	0	A	29556485	A	A	29556485	3	1	294	1	0	0	0	0	1	0	0	0	11056	797	28	4	766	4	OR2H2	6	29556485	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1434816	29556485	141558582	123	54124											
SYNGAP1	8831	broad.mit.edu	37	chr6	33411201	33411203	+	In_Frame_Del	DEL	CAC	-	-																															atggcccaccttcctcccatCaccaccaccaccaccatcac																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:33411201_33411203delCAC	uc011dri.1	+	15	3067_3069	c.2872_2874delCAC	c.(2872-2874)CACdel	p.H966del	SYNGAP1_uc010juy.2_In_Frame_Del_p.H937del|SYNGAP1_uc010juz.2_In_Frame_Del_p.H678del	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	966					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						TTCCTCccatcaccaccaccacc	0.547													---	---	---								-	33411203	-	-	33411201	7	5	294	1	0	1	0	1	0	0	0	0	15513	826	29	0	2930	0	SYNGAP1	6	33411201	In_Frame_Del	DEL	CAC	TCGA-DQ-7595-01A-11D-2229-08	3854716	33411201	137703866	124	54125											
GLP1R	2740	broad.mit.edu	37	chr6	39046126	39046126	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctgctgtttgttgtcccctgGggcattgtcaagtacctcta	5	15	10	11	0	2	0	1	0	1	0	3	0	3	0	3	2	2	5	3	2	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:39046126G>T	uc003ooj.3	+	8	912	c.852G>T	c.(850-852)TGG>TGT	p.W284C	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	284	Helical; Name=4; (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	TTGTCCCCTGGGGCATTGTCA	0.602													27	128					4.23469e-30	6.35203e-30	1	0	T	39046126	T	T	39046126	3	4	294	1	0	0	0	0	1	0	0	0	6489	1241	43	4	882	4	GLP1R	6	39046126	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	5634925	39046126	132068941	125	54126											
UBR2	23304	broad.mit.edu	37	chr6	42574326	42574326	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taattttaaatatctttacaGgggcgtaggtctgttcgata	11	16	9	5	2	2	0	0	0	2	0	3	1	2	0	0	3	1	2	0	3	7	9			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:42574326G>A	uc011dur.1	+	7	802	c.802_splice	c.e7-1	p.G268_splice	UBR2_uc003osf.2_Splice_Site_p.G268_splice	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin						cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			TATCTTTACAGGGGCGTAGGT	0.264													14	80					0	0	0	0	A	42574326	A	A	42574326	5	1	294	1	0	0	0	0	0	0	1	0	16970	1014	35	4	827	4	UBR2	6	42574326	Splice_Site	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3528200	42574326	128540741	126	54127											
C6orf153	88745	broad.mit.edu	37	chr6	42993799	42993799	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccgggaccctcgctttgatGatctgtcaggggaatataat	9	11	11	10	2	2	2	1	2	1	0	3	4	2	4	2	3	0	1	2	3	3	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:42993799G>T	uc003otp.1	+	4	378	c.370G>T	c.(370-372)GAT>TAT	p.D124Y		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	124					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TCGCTTTGATGATCTGTCAGG	0.428													17	50					1.00905e-13	1.29341e-13	1	0	T	42993799	T	T	42993799	3	4	294	1	0	0	0	0	1	0	0	0	2348	1290	45	2	384	2	C6orf153	6	42993799	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	419473	42993799	128121268	127	54128											
CRISP2	7180	broad.mit.edu	37	chr6	49660603	49660603	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttaggagatcttgatactgGcaactattggctgtaacaaa	13	12	9	7	0	1	2	0	1	1	1	1	3	1	2	0	3	3	3	0	3	6	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:49660603G>C	uc003ozq.2	-	10	871	c.615C>G	c.(613-615)TGC>TGG	p.C205W	CRISP2_uc003ozl.2_Missense_Mutation_p.C205W|CRISP2_uc003ozn.2_Missense_Mutation_p.C205W|CRISP2_uc003ozr.2_Missense_Mutation_p.C205W|CRISP2_uc003ozo.2_Missense_Mutation_p.C205W|CRISP2_uc003ozm.2_Missense_Mutation_p.C240W|CRISP2_uc003ozp.2_Missense_Mutation_p.C205W	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	205						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTTGATACTGGCAACTATTGG	0.413													19	46					0	0	0	0	C	49660603	C	C	49660603	3	2	294	1	0	0	0	0	1	0	0	0	3895	1195	42	4	120	4	CRISP2	6	49660603	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	6666804	49660603	121454464	128	54129											
PHF3	23469	broad.mit.edu	37	chr6	64422589	64422589	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caatgtagaggaaaagttgtGttctgcagagaaaaactcgt	15	10	11	5	1	1	2	0	0	1	2	2	4	1	3	0	1	2	4	0	1	6	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:64422589G>T	uc003pep.1	+	15	5131	c.5105G>T	c.(5104-5106)TGT>TTT	p.C1702F	PHF3_uc003pen.2_Missense_Mutation_p.C1614F|PHF3_uc011dxs.1_Missense_Mutation_p.C971F	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1702					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			GAAAAGTTGTGTTCTGCAGAG	0.413													16	59					4.75885e-15	6.25153e-15	1	0	T	64422589	T	T	64422589	3	4	294	1	0	0	0	0	1	0	0	0	11891	1377	48	4	5163	4	PHF3	6	64422589	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	14761986	64422589	106692478	129	54130											
BAI3	577	broad.mit.edu	37	chr6	69685162	69685162	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgctctctcagtcttcatgGagtggccttctgggaacagc	6	12	11	12	0	5	0	2	0	3	0	6	2	5	2	1	3	3	1	1	3	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:69685162G>T	uc003pev.3	+	10	2112	c.1664G>T	c.(1663-1665)GGA>GTA	p.G555V	BAI3_uc010kak.2_Missense_Mutation_p.G555V	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	555	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AGTCTTCATGGAGTGGCCTTC	0.468													10	53					1.58986e-06	1.73328e-06	1	0	T	69685162	T	T	69685162	3	4	294	1	0	0	0	0	1	0	0	0	1302	1174	41	2	1694	2	BAI3	6	69685162	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	5262573	69685162	101429905	130	54131											
BAI3	577	broad.mit.edu	37	chr6	70071009	70071009	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtgaattgcggagaactgtgTacttatgtacggatgataat	12	13	12	4	2	0	3	0	2	0	1	0	5	0	4	0	2	4	2	0	2	6	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:70071009T>G	uc003pev.3	+	29	4292	c.3844T>G	c.(3844-3846)TAC>GAC	p.Y1282D	BAI3_uc010kak.2_Missense_Mutation_p.Y1282D|BAI3_uc011dxx.1_Missense_Mutation_p.Y488D	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1282	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GAGAACTGTGTACTTATGTAC	0.413													20	65					0	0	0	0	G	70071009	G	G	70071009	3	3	294	1	0	0	0	0	1	0	0	0	1302	1638	57	5	3950	5	BAI3	6	70071009	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	385847	70071009	101044058	131	54132											
SNAP91	9892	broad.mit.edu	37	chr6	84311131	84311131	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgaaatctgtgcttcagaggGaacagaggaaagtgcagcca	14	7	13	7	0	2	3	1	1	1	2	2	5	2	5	1	2	4	2	1	2	3	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:84311131G>A	uc011dze.1	-	15	1500	c.1183C>T	c.(1183-1185)CCC>TCC	p.P395S	SNAP91_uc011dzd.1_5'UTR|SNAP91_uc003pkb.2_Missense_Mutation_p.P358S|SNAP91_uc003pkc.2_Missense_Mutation_p.P393S|SNAP91_uc003pkd.2_Intron|SNAP91_uc003pka.2_Missense_Mutation_p.P393S	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	395	Ala-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		GCTTCAGAGGGAACAGAGGAA	0.448													9	21					0	0	0	0	A	84311131	A	A	84311131	3	1	294	1	0	0	0	0	1	0	0	0	14897	1174	41	2	1596	2	SNAP91	6	84311131	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	14240122	84311131	86803936	132	54133											
PRDM13	59336	broad.mit.edu	37	chr6	100061923	100061923	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctacaacggggagctgctctAcggctcaccggccaccaccg	8	5	11	17	4	2	0	1	0	1	0	2	1	2	1	4	4	5	3	4	4	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:100061923A>G	uc003pqg.1	+	4	1673	c.1412A>G	c.(1411-1413)TAC>TGC	p.Y471C		NM_021620	NP_067633	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	471					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		GAGCTGCTCTACGGCTCACCG	0.637													24	89					0	0	0	0	G	100061923	G	G	100061923	3	3	294	1	0	0	0	0	1	0	0	0	12516	391	14	5	1426	5	PRDM13	6	100061923	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	15750792	100061923	71053144	133	54134											
GPR6	2830	broad.mit.edu	37	chr6	110300652	110300652	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgttcgtgctggtaggcAgcctggccaccgctgacctg	5	9	13	14	2	0	1	0	1	0	0	1	1	0	1	5	3	2	5	5	3	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:110300652A>T	uc011eaw.1	+	2	517	c.337A>T	c.(337-339)AGC>TGC	p.S113C	GPR6_uc011eav.1_Missense_Mutation_p.S128C|GPR6_uc003ptu.2_Missense_Mutation_p.S113C	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	113	Helical; Name=2; (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		GCTGGTAGGCAGCCTGGCCAC	0.642													38	147					0	0	0	0	T	110300652	T	T	110300652	3	4	294	1	0	0	0	0	1	0	0	0	6739	188	7	5	339	5	GPR6	6	110300652	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	10238729	110300652	60814415	134	54135											
GPR6	2830	broad.mit.edu	37	chr6	110300952	110300952	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctggaactgcctggcagagCgcgccgcctgcagcgtggtg	5	6	17	13	4	0	1	0	0	0	1	0	2	0	2	3	3	5	3	3	3	1	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:110300952C>A	uc011eaw.1	+	2	817	c.637C>A	c.(637-639)CGC>AGC	p.R213S	GPR6_uc011eav.1_Missense_Mutation_p.R228S|GPR6_uc003ptu.2_Missense_Mutation_p.R213S	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	213	Extracellular (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		CCTGGCAGAGCGCGCCGCCTG	0.697													9	13					7.48243e-07	8.24236e-07	1	0	A	110300952	A	A	110300952	3	1	294	1	0	0	0	0	1	0	0	0	6739	768	27	3	639	3	GPR6	6	110300952	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	300	110300952	60814115	135	54136											
TSPYL4	23270	broad.mit.edu	37	chr6	116573958	116573958	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaacctgaaggatctggcgCtctccactggctgccttggt	6	10	13	12	1	2	1	0	1	2	0	3	3	2	3	3	5	2	2	3	5	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:116573958C>T	uc003pwn.2	-	1	1304	c.1214G>A	c.(1213-1215)AGC>AAC	p.S405N	DSE_uc011ebf.1_5'Flank|TSPYL4_uc011ebe.1_Missense_Mutation_p.S233N|uc003pwo.1_5'Flank	NM_021648	NP_067680	Q9UJ04	TSYL4_HUMAN	TSPY-like 4	405					nucleosome assembly	nucleus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.045)|OV - Ovarian serous cystadenocarcinoma(136;0.0666)|GBM - Glioblastoma multiforme(226;0.095)|Epithelial(106;0.125)		GGATCTGGCGCTCTCCACTGG	0.532													3	13					0	0	0	0	T	116573958	T	T	116573958	3	4	294	1	0	0	0	0	1	0	0	0	16728	797	28	4	34	4	TSPYL4	6	116573958	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	6273006	116573958	54541109	136	54137											
LAMA2	3908	broad.mit.edu	37	chr6	129470220	129470220	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggagagctggaacttttCtaactaaaactgaatgtgaa	14	11	9	7	0	1	3	0	2	1	1	1	5	1	4	1	2	4	1	1	2	6	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:129470220C>A	uc003qbn.2	+	7	1111	c.1006C>A	c.(1006-1008)CTA>ATA	p.L336I	LAMA2_uc003qbo.2_Missense_Mutation_p.L336I	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	336	Laminin EGF-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGGAACTTTTCTAACTAAAAC	0.393													11	47					0.000978159	0.00100917	1	0	A	129470220	A	A	129470220	3	1	294	1	0	0	0	0	1	0	0	0	8646	912	32	2	1032	2	LAMA2	6	129470220	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	12896262	129470220	41644847	137	54138											
TMEM200A	114801	broad.mit.edu	37	chr6	130762041	130762041	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacaaagagaccaaaatcatAcacatgagggatatctattc	18	8	7	8	0	2	2	1	1	1	1	3	5	2	3	1	1	1	0	1	1	6	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:130762041A>T	uc003qca.2	+	3	1345	c.474A>T	c.(472-474)ATA>ATT	p.I158I	TMEM200A_uc010kfh.2_Silent_p.I158I|TMEM200A_uc010kfi.2_Silent_p.I158I|TMEM200A_uc003qcb.2_Silent_p.I158I	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	158	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CCAAAATCATACACATGAGGG	0.408													23	72					0	0	0	0	T	130762041	T	T	130762041	2	4	294	1	0	0	0	0	0	0	0	1	16189	381	14	5		5	TMEM200A	6	130762041	Silent	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	1291821	130762041	40353026	138	54139											
EYA4	2070	broad.mit.edu	37	chr6	133785942	133785942	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agttttgcaccatcatctacTatttatgcaaataattcagt	13	16	4	8	0	3	0	2	0	1	0	3	0	3	0	1	0	3	3	1	0	5	8			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:133785942T>G	uc003qec.3	+	10	1208	c.750T>G	c.(748-750)ACT>ACG	p.T250T	EYA4_uc011ecq.1_Silent_p.T196T|EYA4_uc011ecr.1_Silent_p.T196T|EYA4_uc003qed.3_Silent_p.T250T|EYA4_uc003qee.3_Silent_p.T227T|EYA4_uc011ecs.1_Silent_p.T250T|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	250					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CATCATCTACTATTTATGCAA	0.284													9	27					0	0	0	0	G	133785942	G	G	133785942	2	3	294	1	0	0	0	0	0	0	0	1	5356	1509	53	5		5	EYA4	6	133785942	Silent	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	3023901	133785942	37329125	139	54140											
KIAA1244	57221	broad.mit.edu	37	chr6	138584501	138584501	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactcgggcaggtccgacgtGtcagacattgggtcggacaa	9	7	15	10	4	1	1	1	0	0	1	4	4	2	2	1	4	0	1	1	4	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:138584501G>T	uc003qhu.2	+	12	1881	c.1881G>T	c.(1879-1881)GTG>GTT	p.V627V		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	627	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GGTCCGACGTGTCAGACATTG	0.542													60	217					3.33906e-19	4.72382e-19	1	0	T	138584501	T	T	138584501	2	4	294	1	0	0	0	0	0	0	0	1	8256	1364	48	4		4	KIAA1244	6	138584501	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	4798559	138584501	32530566	140	54141											
NUP43	348995	broad.mit.edu	37	chr6	150052870	150052870	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgaaagtgaacttcccaCactaagagacaagaatcaat	17	7	9	8	0	1	4	1	2	0	2	2	5	2	4	1	1	1	0	1	1	6	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:150052870C>A	uc003qmz.2	-	7	849	c.792G>T	c.(790-792)ATG>ATT	p.M264I	NUP43_uc003qmx.3_RNA|NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Silent_p.V168V	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	264	WD 6.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		GAACTTCCCACACTAAGAGAC	0.448													19	74					4.96729e-08	5.69421e-08	1	0	A	150052870	A	A	150052870	3	1	294	1	0	0	0	0	1	0	0	0	10819	492	17	4	358	4	NUP43	6	150052870	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	11468369	150052870	21062197	141	54142											
SYNE1	23345	broad.mit.edu	37	chr6	152763213	152763213	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	taacttccggctcctacctgGatgcggcgttcctgcctctc	4	12	9	16	3	1	0	0	0	1	0	5	1	4	1	5	3	4	2	5	3	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:152763213G>C	uc010kiw.2	-	31	4607	c.4005C>G	c.(4003-4005)ATC>ATG	p.I1335M	SYNE1_uc003qot.3_Missense_Mutation_p.I1342M|SYNE1_uc003qou.3_Missense_Mutation_p.I1335M|SYNE1_uc010kjb.1_Missense_Mutation_p.I1318M|SYNE1_uc003qow.2_Missense_Mutation_p.I630M|SYNE1_uc003qox.1_Missense_Mutation_p.I851M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1335	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCCTACCTGGATGCGGCGTT	0.577										HNSCC(10;0.0054)			42	133					0	0	0	0	C	152763213	C	C	152763213	3	2	294	1	0	0	0	0	1	0	0	0	15511	1164	41	2	22925	2	SYNE1	6	152763213	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2710343	152763213	18351854	142	54143											
MLLT4	4301	broad.mit.edu	37	chr6	168227285	168227285	+	5'Flank	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccaacacagcaccacccatCggacccagcactgcccattt	11	5	5	20	1	0	0	0	0	0	0	1	1	0	1	5	1	4	2	5	1	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr6:168227285C>T	uc003qwd.2	+						MLLT4_uc003qwb.1_5'Flank|MLLT4_uc003qwc.1_5'Flank|C6orf124_uc003qwa.2_RNA	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia						adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CACCACCCATCGGACCCAGCA	0.672			T	MLL	AL								14	41					0	0	0	0	T	168227285	T	T	168227285	1	4	294	0	1	0	0	0	0	0	0	0	9682	899	31	1		1	MLLT4	6	168227285	5'Flank	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	15464072	168227285	2887782	143	54144											
MAD1L1	8379	broad.mit.edu	37	chr7	2265108	2265108	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcgagccctcttgtgactCagctccatctgcattttctc	6	14	6	15	1	4	1	1	1	3	0	7	2	5	1	2	0	3	2	2	0	0	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:2265108C>A	uc003slh.1	-	4	494	c.228G>T	c.(226-228)CTG>CTT	p.L76L	MAD1L1_uc003slf.1_Silent_p.L76L|MAD1L1_uc003slg.1_Silent_p.L76L|MAD1L1_uc010ksh.1_Silent_p.L76L|MAD1L1_uc003sli.1_Intron|MAD1L1_uc010ksi.1_Intron|MAD1L1_uc010ksj.2_Silent_p.L76L	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	76	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TCTTGTGACTCAGCTCCATCT	0.612													28	93					2.12542e-12	2.65991e-12	1	0	A	2265108	A	A	2265108	2	1	294	1	0	0	0	0	0	0	0	1	9198	813	29	2		2	MAD1L1	7	2265108	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08		2265108	156873555	144	54145											
MACC1	346389	broad.mit.edu	37	chr7	20197937	20197937	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttctttgtctgcttgaatttGatcaaaatcttccagggaca	10	16	7	8	0	4	2	1	2	3	0	5	3	5	3	1	1	1	1	1	1	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:20197937G>C	uc003sus.3	-	5	2356	c.2047C>G	c.(2047-2049)CAA>GAA	p.Q683E	MACC1_uc010kug.2_Missense_Mutation_p.Q683E	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	683					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						GCTTGAATTTGATCAAAATCT	0.353													12	40					0	0	0	0	C	20197937	C	C	20197937	3	2	294	1	0	0	0	0	1	0	0	0	9194	1299	45	2	523	2	MACC1	7	20197937	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	17932829	20197937	138940726	145	54146											
SP4	6671	broad.mit.edu	37	chr7	21550667	21550667	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gagatttgaatgcccggaatGttctaaaaggtttatgcgga	12	12	12	5	2	1	2	0	1	1	1	1	5	1	4	1	3	2	2	1	3	5	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:21550667G>A	uc003sva.2	+	6	2316	c.2135G>A	c.(2134-2136)TGT>TAT	p.C712Y	SP4_uc003svb.2_Missense_Mutation_p.C399Y	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	712	C2H2-type 3.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						TGCCCGGAATGTTCTAAAAGG	0.373													23	48					0	0	0	0	A	21550667	A	A	21550667	3	1	294	1	0	0	0	0	1	0	0	0	15030	1377	48	4	2157	4	SP4	7	21550667	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1352730	21550667	137587996	146	54147											
NEUROD6	63974	broad.mit.edu	37	chr7	31378538	31378538	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggaccacttttcttaagttGtccagagcgtcgttgaggcc	7	12	12	10	2	1	2	0	1	1	1	3	3	2	3	3	2	1	2	3	2	1	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:31378538G>T	uc003tch.2	-	2	698	c.345C>A	c.(343-345)GAC>GAA	p.D115E		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	115	Helix-loop-helix motif.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						TTCTTAAGTTGTCCAGAGCGT	0.473													25	72					1.33986e-20	1.92123e-20	1	0	T	31378538	T	T	31378538	3	4	294	1	0	0	0	0	1	0	0	0	10405	1368	48	4	672	4	NEUROD6	7	31378538	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	9827871	31378538	127760125	147	54148											
POM121L12	285877	broad.mit.edu	37	chr7	53103798	53103798	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcgggatcgcgccccctgAgcgtcaggagagcccctgga	7	5	14	15	4	1	2	1	1	0	1	3	5	1	4	4	3	2	0	4	3	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:53103798A>T	uc003tpz.2	+	1	450	c.434A>T	c.(433-435)GAG>GTG	p.E145V		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	145											0						GCGCCCCCTGAGCGTCAGGAG	0.577													13	29					0	0	0	0	T	53103798	T	T	53103798	3	4	294	1	0	0	0	0	1	0	0	0	12296	304	11	5	436	5	POM121L12	7	53103798	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	21725260	53103798	106034865	148	54149											
ZNF92	168374	broad.mit.edu	37	chr7	64864433	64864433	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tagtgtattctcaacccttaCtaaacataaaataattcata	17	14	2	8	0	2	0	2	0	1	0	3	0	2	0	1	0	3	1	1	0	10	9			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:64864433C>G	uc003ttz.2	+	4	1549	c.1406C>G	c.(1405-1407)ACT>AGT	p.T469S	ZNF92_uc003tua.2_Missense_Mutation_p.T400S|ZNF92_uc010kzu.2_Missense_Mutation_p.T437S|ZNF92_uc003tub.2_Missense_Mutation_p.T393S	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	469	C2H2-type 12.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)				TCAACCCTTACTAAACATAAA	0.323													11	26					0	0	0	0	G	64864433	G	G	64864433	3	3	294	1	0	0	0	0	1	0	0	0	18268	565	20	4	1420	4	ZNF92	7	64864433	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	11760635	64864433	94274230	149	54150											
TYW1B	441250	broad.mit.edu	37	chr7	72159756	72159756	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggtcgattttcttcaggCtgtctttggtactggcatcc	4	15	12	10	2	3	0	1	0	2	0	5	1	4	0	1	5	1	3	1	5	1	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:72159756C>A	uc011kej.1	-	14	1586	c.1427G>T	c.(1426-1428)AGC>ATC	p.S476I	TYW1B_uc011keh.1_Missense_Mutation_p.S314I|TYW1B_uc011kei.1_Missense_Mutation_p.S102I	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	476					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						TTTCTTCAGGCTGTCTTTGGT	0.393													19	59					0.000175454	0.00018462	1	0	A	72159756	A	A	72159756	3	1	294	1	0	0	0	0	1	0	0	0	16887	797	28	4	716	4	TYW1B	7	72159756	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	7295323	72159756	86978907	150	54151											
SEMA3A	10371	broad.mit.edu	37	chr7	83610669	83610669	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaatagcgagaacatgcAgaaccatcccaagcacagta	18	4	9	10	1	0	2	0	0	0	2	1	4	1	3	2	1	5	3	2	1	7	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:83610669A>T	uc003uhz.2	-	14	1935	c.1620T>A	c.(1618-1620)TCT>TCA	p.S540S		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	540					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						GAGAACATGCAGAACCATCCC	0.448													13	50					0	0	0	0	T	83610669	T	T	83610669	2	4	294	1	0	0	0	0	0	0	0	1	14089	175	7	5		5	SEMA3A	7	83610669	Silent	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	11450913	83610669	75527994	151	54152											
STEAP4	79689	broad.mit.edu	37	chr7	87912279	87912279	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataagggtagattacgtctcTtataacacaatagaaaaaca	19	10	6	6	1	1	2	0	0	1	2	2	2	1	2	0	1	3	1	0	1	9	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:87912279T>C	uc003ujs.2	-	3	766	c.661A>G	c.(661-663)AGA>GGA	p.R221G	STEAP4_uc010lek.2_Intron|STEAP4_uc003ujt.2_Missense_Mutation_p.R221G	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	221					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					ATTACGTCTCTTATAACACAA	0.363													25	72					0	0	0	0	C	87912279	C	C	87912279	3	2	294	1	0	0	0	0	1	0	0	0	15346	1617	56	5	730	5	STEAP4	7	87912279	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	4301610	87912279	71226384	152	54153											
CDK6	1021	broad.mit.edu	37	chr7	92300836	92300836	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agacttcgggtgctctgtacCacagcgtgacgacctgcaat	9	9	11	12	3	1	2	0	1	1	1	2	3	1	2	2	1	4	3	2	1	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:92300836C>T	uc011khw.1	-	5	963	c.551G>A	c.(550-552)TGG>TAG	p.W184*	CDK6_uc010lez.2_Nonsense_Mutation_p.W184*	NM_001259	NP_001250	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	184	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			central_nervous_system(1)|skin(1)	2	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TGCTCTGTACCACAGCGTGAC	0.502			T	MLLT10	ALL								21	54					0	0	0	0	T	92300836	T	T	92300836	4	4	294	1	0	0	0	0	0	1	0	0	3163	595	21	4	445	4	CDK6	7	92300836	Nonsense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	4388557	92300836	66837827	153	54154											
PPP1R9A	55607	broad.mit.edu	37	chr7	94539822	94539822	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatttgacactatgtacgatGgcccttcatattccaagttc	10	14	7	10	1	1	1	1	1	0	0	3	3	2	1	2	1	1	2	2	1	4	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:94539822G>T	uc003unp.2	+	2	679	c.397G>T	c.(397-399)GGC>TGC	p.G133C	PPP1R9A_uc010lfj.2_Missense_Mutation_p.G133C|PPP1R9A_uc011kif.1_Missense_Mutation_p.G133C|PPP1R9A_uc003unq.2_Missense_Mutation_p.G133C|PPP1R9A_uc011kig.1_Missense_Mutation_p.G133C	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	133	Actin-binding.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TATGTACGATGGCCCTTCATA	0.403										HNSCC(28;0.073)			36	135					4.49093e-37	6.858e-37	1	0	T	94539822	T	T	94539822	3	4	294	1	0	0	0	0	1	0	0	0	12438	1348	47	4	399	4	PPP1R9A	7	94539822	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2238986	94539822	64598841	154	54155											
SH2B2	10603	broad.mit.edu	37	chr7	101944494	101944494	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctcggctcagtggcagaaGtgccgcctgctcctgcgcag	5	7	15	14	3	1	1	1	0	0	1	3	1	2	1	3	3	3	5	3	3	1	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:101944494G>C	uc011kko.1	+	2	834	c.789G>C	c.(787-789)AAG>AAC	p.K263N		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	220	PH.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0						AGTGGCAGAAGTGCCGCCTGC	0.677													6	10					0	0	0	0	C	101944494	C	C	101944494	3	2	294	1	0	0	0	0	1	0	0	0	14293	1020	36	4	795	4	SH2B2	7	101944494	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	7404672	101944494	57194169	155	54156											
RELN	5649	broad.mit.edu	37	chr7	103123389	103123389	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtggcgtggttgccaccagCgcagtaagactcctttcatc	7	11	11	12	2	1	1	1	0	0	1	3	1	2	1	3	2	2	3	3	2	1	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:103123389C>T	uc003vca.2	-	63	10371	c.10211G>A	c.(10210-10212)CGC>CAC	p.R3404H	RELN_uc010liz.2_Missense_Mutation_p.R3404H	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3404					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTGCCACCAGCGCAGTAAGAC	0.473													33	74					0	0	0	0	T	103123389	T	T	103123389	3	4	294	1	0	0	0	0	1	0	0	0	13285	768	27	1	183	1	RELN	7	103123389	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1178895	103123389	56015274	156	54157											
PODXL	5420	broad.mit.edu	37	chr7	131191357	131191357	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtgaatagtgatttctttGacgaccacggtctgacttcc	8	14	9	10	2	2	4	0	4	2	0	3	5	3	4	2	1	0	0	2	1	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:131191357G>A	uc003vqw.3	-	6	1488	c.1230C>T	c.(1228-1230)GTC>GTT	p.V410V	PODXL_uc003vqx.3_Silent_p.V378V	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	podocalyxin-like isoform 1 precursor	410	Extracellular (Potential).				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)					TGATTTCTTTGACGACCACGG	0.582											OREG0018320	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	52	172					0	0	0	0	A	131191357	A	A	131191357	2	1	294	1	0	0	0	0	0	0	0	1	12235	1277	45	2		2	PODXL	7	131191357	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	28067968	131191357	27947306	157	54158											
UBN2	254048	broad.mit.edu	37	chr7	138964071	138964071	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttttatcttagggcaaagAaaaaggtgattcctgcacct	12	13	8	8	0	1	2	0	1	1	1	2	2	2	2	2	2	1	2	2	2	5	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:138964071A>G	uc011kqr.1	+	13	2032	c.2032A>G	c.(2032-2034)AAA>GAA	p.K678E		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	678										ovary(1)|skin(1)	2						TAGGGCAAAGAAAAAGGTGAT	0.284													19	47					0	0	0	0	G	138964071	G	G	138964071	3	3	294	1	0	0	0	0	1	0	0	0	16961	247	9	5	2082	5	UBN2	7	138964071	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	7772714	138964071	20174592	158	54159											
OR2F2	135948	broad.mit.edu	37	chr7	143632858	143632858	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	caagtttattgatcacatatCctgtgaactcctagctgtgg	10	14	8	9	0	1	2	1	2	0	0	3	2	3	2	2	1	2	2	2	1	5	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:143632858C>A	uc011ktv.1	+	1	533	c.533C>A	c.(532-534)TCC>TAC	p.S178Y		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					GATCACATATCCTGTGAACTC	0.498													24	90					9.39395e-14	1.20779e-13	1	0	A	143632858	A	A	143632858	3	1	294	1	0	0	0	0	1	0	0	0	11051	855	30	2	535	2	OR2F2	7	143632858	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	4668787	143632858	15505805	159	54160											
ZNF398	57541	broad.mit.edu	37	chr7	148876806	148876806	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccaggtcccctcataactggGcttgaaacttctggcctggg	7	10	11	13	0	2	1	1	1	1	0	3	1	3	1	4	4	2	1	4	4	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:148876806G>T	uc003wfl.2	+	6	2117	c.1842G>T	c.(1840-1842)GGG>GGT	p.G614G	ZNF398_uc011kul.1_Silent_p.G443G|ZNF398_uc011kum.1_Silent_p.G619G	NM_170686	NP_733787	Q8TD17	ZN398_HUMAN	zinc finger 398 isoform a	614					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			TCATAACTGGGCTTGAAACTT	0.552													10	39					7.48243e-07	8.24236e-07	1	0	T	148876806	T	T	148876806	2	4	294	1	0	0	0	0	0	0	0	1	17952	1190	42	4		4	ZNF398	7	148876806	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	5243948	148876806	10261857	160	54161											
NOS3	4846	broad.mit.edu	37	chr7	150710899	150710899	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggggccacatgtttgtctgcGgcgatgttaccatggcaacc	7	10	13	11	2	1	0	0	0	1	0	1	1	1	0	3	4	3	3	3	4	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:150710899G>A	uc003wif.2	+	26	3639	c.3343G>A	c.(3343-3345)GGC>AGC	p.G1115S	NOS3_uc011kuy.1_Missense_Mutation_p.G909S|ATG9B_uc003wig.3_RNA|ATG9B_uc011kvc.1_3'UTR	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	1115	NADP (By similarity).				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GTTTGTCTGCGGCGATGTTAC	0.677													7	32					0	0	0	0	A	150710899	A	A	150710899	3	1	294	1	0	0	0	0	1	0	0	0	10598	1116	39	1	3723	1	NOS3	7	150710899	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1834093	150710899	8427764	161	54162											
PTPRN2	5799	broad.mit.edu	37	chr7	157475424	157475424	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agtctcctcttacctggtagGcggcagtggcatctgcacct	6	11	11	13	1	3	0	0	0	3	0	4	0	3	0	3	4	2	4	3	4	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr7:157475424G>A	uc003wno.2	-	13	2115	c.1994C>T	c.(1993-1995)GCC>GTC	p.A665V	PTPRN2_uc003wnp.2_Missense_Mutation_p.A648V|PTPRN2_uc003wnq.2_Missense_Mutation_p.A636V|PTPRN2_uc003wnr.2_Missense_Mutation_p.A627V|PTPRN2_uc011kwa.1_Missense_Mutation_p.A688V	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	665	Cytoplasmic (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TACCTGGTAGGCGGCAGTGGC	0.557													53	180					0	0	0	0	A	157475424	A	A	157475424	3	1	294	1	0	0	0	0	1	0	0	0	12873	1203	42	4	1097	4	PTPRN2	7	157475424	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	6764525	157475424	1663239	162	54163											
MYOM2	9172	broad.mit.edu	37	chr8	2054178	2054178	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggtttaaaatcgaaaccGtgggggatcagtaagtcagg	14	8	14	5	2	2	1	2	0	0	1	3	3	2	2	1	4	1	2	1	4	4	3	rs140995511		TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:2054178G>A	uc003wpx.3	+	22	3019	c.2881G>A	c.(2881-2883)GTG>ATG	p.V961M	MYOM2_uc011kwi.1_Missense_Mutation_p.V386M	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	961	Ig-like C2-type 3.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AATCGAAACCGTGGGGGATCA	0.448													19	78					0	0	0	0	A	2054178	A	A	2054178	3	1	294	1	0	0	0	0	1	0	0	0	10145	1145	40	1	2963	1	MYOM2	8	2054178	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08		2054178	144309844	163	54164											
CSMD1	64478	broad.mit.edu	37	chr8	2886890	2886890	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttccacgtcccattggcctgGcaccgcaggagcctccagcc	6	7	10	18	2	0	0	0	0	0	0	3	1	3	1	7	3	2	2	7	3	0	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:2886890G>T	uc011kwk.1	-	51	8199	c.7809C>A	c.(7807-7809)TGC>TGA	p.C2603*	CSMD1_uc011kwj.1_Nonsense_Mutation_p.C1932*|CSMD1_uc010lrg.2_Nonsense_Mutation_p.C671*	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2603	Extracellular (Potential).|Sushi 16.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CATTGGCCTGGCACCGCAGGA	0.532													9	28					5.50884e-06	5.97497e-06	1	0	T	2886890	T	T	2886890	4	4	294	1	0	0	0	0	0	1	0	0	3961	1195	42	4	2968	4	CSMD1	8	2886890	Nonsense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	832712	2886890	143477132	164	54165											
DLC1	10395	broad.mit.edu	37	chr8	13259101	13259101	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagcaccatggagtccagccGcgccctatctcgatcttctc	7	9	8	17	3	3	0	0	0	3	0	6	2	4	1	4	1	2	1	4	1	1	2	rs144283917		TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:13259101G>A	uc003wwm.2	-	3	1495	c.1051C>T	c.(1051-1053)CGG>TGG	p.R351W	DLC1_uc003wwn.2_Missense_Mutation_p.R351W|DLC1_uc011kxy.1_Missense_Mutation_p.R351W	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	351					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GAGTCCAGCCGCGCCCTATCT	0.448													22	85					0	0	0	0	A	13259101	A	A	13259101	3	1	294	1	0	0	0	0	1	0	0	0	4572	1086	38	1	3684	1	DLC1	8	13259101	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	10372211	13259101	133104921	165	54166											
SGCZ	137868	broad.mit.edu	37	chr8	13948076	13948077	+	Frame_Shift_Ins	INS	-	T	T																															ctgtcgagaacttgaggagcINStgggtgaagaagatgagaag																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:13948076_13948077insT	uc003wwq.2	-	8	1474_1475	c.814_815insA	c.(814-816)AGCfs	p.S272fs	SGCZ_uc010lss.2_Frame_Shift_Ins_p.S225fs	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	259	Poly-Ser.|Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		ACTTGAGGAGCTGGGTGAAGAA	0.431													---	---	---								T	13948077	T	T	13948076	7	5	294	1	0	1	1	0	0	0	0	0	14269	797	28	0	127	0	SGCZ	8	13948076	Frame_Shift_Ins	INS	-	TCGA-DQ-7595-01A-11D-2229-08	688975	13948076	132415946	166	54167											
STMN4	81551	broad.mit.edu	37	chr8	27099981	27099981	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gagcagaacaaggacaccagCgggagctccttcatcttctc	11	7	10	13	1	3	1	1	0	2	1	5	4	4	3	2	2	4	2	2	2	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:27099981C>A	uc003xfk.2	-	3	156	c.42G>T	c.(40-42)CCG>CCT	p.P14P	STMN4_uc003xfj.2_Silent_p.P14P|STMN4_uc011lai.1_Silent_p.P14P|STMN4_uc011laj.1_Silent_p.P5P|STMN4_uc011lak.1_Silent_p.P14P|STMN4_uc010luo.2_Silent_p.P14P			Q9H169	STMN4_HUMAN	RecName: Full=Stathmin-4; AltName: Full=Stathmin-like protein B3;          Short=RB3;	14					intracellular signal transduction					large_intestine(1)|pancreas(1)	2		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)		AGGACACCAGCGGGAGCTCCT	0.567													10	57					0.000442599	0.000459999	1	0	A	27099981	A	A	27099981	2	1	294	1	0	0	0	0	0	0	0	1	15377	755	27	3		3	STMN4	8	27099981	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	13151905	27099981	119264041	167	54168											
UNC5D	137970	broad.mit.edu	37	chr8	35542108	35542108	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttctctctcagtgaatggaGgctggtcttcctggacagag	7	13	12	9	0	3	2	1	1	3	1	6	4	4	4	1	4	0	1	1	4	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:35542108G>A	uc003xjr.1	+	6	1088	c.760G>A	c.(760-762)GGC>AGC	p.G254S	UNC5D_uc003xjs.1_Missense_Mutation_p.G249S|UNC5D_uc003xjt.1_Missense_Mutation_p.G23S	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	254	TSP type-1 1.|Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AGTGAATGGAGGCTGGTCTTC	0.418													28	87					0	0	0	0	A	35542108	A	A	35542108	3	1	294	1	0	0	0	0	1	0	0	0	17063	1000	35	4	782	4	UNC5D	8	35542108	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	8442127	35542108	110821914	168	54169											
UNC5D	137970	broad.mit.edu	37	chr8	35583803	35583803	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcactctttaaccctttgtcGgacatcaaagtgaaagtcca	12	12	6	11	1	3	1	2	1	1	0	5	2	4	2	2	1	1	0	2	1	3	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:35583803G>A	uc003xjr.1	+	10	1765	c.1437G>A	c.(1435-1437)TCG>TCA	p.S479S	UNC5D_uc003xjs.1_Silent_p.S474S|UNC5D_uc003xju.1_Silent_p.S55S|UNC5D_uc003xjt.1_Silent_p.S237S	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	479	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		ACCCTTTGTCGGACATCAAAG	0.522													6	26					0	0	0	0	A	35583803	A	A	35583803	2	1	294	1	0	0	0	0	0	0	0	1	17063	1103	39	1		1	UNC5D	8	35583803	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	41695	35583803	110780219	169	54170											
ADAM18	8749	broad.mit.edu	37	chr8	39587436	39587436	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtaattcatccgttgtatcaGaaagcgatgacgtgggacat	12	11	11	7	3	2	2	2	1	0	1	3	4	3	3	1	1	1	3	1	1	3	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:39587436G>C	uc003xni.2	+	20	2197	c.2197G>C	c.(2197-2199)GAA>CAA	p.E733Q	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.E709Q	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	733	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CGTTGTATCAGAAAGCGATGA	0.323													22	71					0	0	0	0	C	39587436	C	C	39587436	3	2	294	1	0	0	0	0	1	0	0	0	239	943	33	2	2275	2	ADAM18	8	39587436	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	4003633	39587436	106776586	170	54171											
ANK1	286	broad.mit.edu	37	chr8	41585479	41585479	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacaagctcccggaccacctCatcctgcccggctagagcag	9	5	10	17	2	1	1	1	0	0	1	3	3	3	2	5	2	3	3	5	2	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:41585479C>T	uc003xok.2	-	4	358	c.274G>A	c.(274-276)GAG>AAG	p.E92K	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.E92K|ANK1_uc003xoj.2_Missense_Mutation_p.E92K|ANK1_uc003xol.2_Missense_Mutation_p.E92K|ANK1_uc003xom.2_Missense_Mutation_p.E125K	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	92	89 kDa domain.|ANK 2.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CGGACCACCTCATCCTGCCCG	0.602													21	101					0	0	0	0	T	41585479	T	T	41585479	3	4	294	1	0	0	0	0	1	0	0	0	620	835	29	2	5881	2	ANK1	8	41585479	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1998043	41585479	104778543	171	54172											
CHRNA6	8973	broad.mit.edu	37	chr8	42620288	42620288	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccacaggcctgatgaactGgttgtaatgagaaaacagtt	13	11	10	7	0	0	3	0	3	0	1	1	4	1	3	2	2	2	3	2	2	4	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:42620288G>C	uc003xpj.2	-	2	185	c.139C>G	c.(139-141)CAG>GAG	p.Q47E	CHRNA6_uc011lcw.1_Missense_Mutation_p.Q47E	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	47	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CTGATGAACTGGTTGTAATGA	0.547													41	148					0	0	0	0	C	42620288	C	C	42620288	3	2	294	1	0	0	0	0	1	0	0	0	3402	1357	47	4	1365	4	CHRNA6	8	42620288	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1034809	42620288	103743734	172	54173											
OPRK1	4986	broad.mit.edu	37	chr8	54141939	54141939	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggactctgctagtgctctgcCgctccatcctcatcttcagt	5	13	8	15	1	5	0	2	0	3	0	7	1	7	1	3	1	3	3	3	1	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:54141939C>A	uc003xrh.1	-	3	1436	c.1061G>T	c.(1060-1062)CGG>CTG	p.R354L	OPRK1_uc003xri.1_Missense_Mutation_p.R354L|OPRK1_uc010lyc.1_Missense_Mutation_p.R265L	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	354	Cytoplasmic (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	AGTGCTCTGCCGCTCCATCCT	0.483													17	56					2.35188e-11	2.91744e-11	1	0	A	54141939	A	A	54141939	3	1	294	1	0	0	0	0	1	0	0	0	10939	652	23	3	85	3	OPRK1	8	54141939	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	11521651	54141939	92222083	173	54174											
RP1	6101	broad.mit.edu	37	chr8	55534123	55534123	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgccctgtggtcaagctgtaCgctacggacggaaggagggt	8	7	16	10	4	1	0	1	0	0	0	1	3	1	3	1	5	3	3	1	5	4	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:55534123C>T	uc003xsd.1	+	2	745	c.597C>T	c.(595-597)TAC>TAT	p.Y199Y	RP1_uc011ldy.1_Silent_p.Y199Y	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	199	Doublecortin 2.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TCAAGCTGTACGCTACGGACG	0.577													57	190					0	0	0	0	T	55534123	T	T	55534123	2	4	294	1	0	0	0	0	0	0	0	1	13597	547	19	1		1	RP1	8	55534123	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1392184	55534123	90829899	174	54175											
SLC7A13	157724	broad.mit.edu	37	chr8	87242276	87242276	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaatagtattgagctccActgcatgggaagcttatact	14	11	9	7	0	0	2	0	1	0	1	1	3	1	3	1	1	4	4	1	1	7	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:87242276A>G	uc003ydq.1	-	1	329	c.231T>C	c.(229-231)AGT>AGC	p.S77S	SLC7A13_uc003ydr.1_Silent_p.S77S	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	77	Cytoplasmic (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						ATTGAGCTCCACTGCATGGGA	0.493													12	30					0	0	0	0	G	87242276	G	G	87242276	2	3	294	1	0	0	0	0	0	0	0	1	14759	156	6	5		5	SLC7A13	8	87242276	Silent	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	31708153	87242276	59121746	175	54176											
MMP16	4325	broad.mit.edu	37	chr8	89068364	89068364	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtatactgacctgtctccCttgaagaaataggttttccc	9	14	8	10	0	1	3	0	2	1	1	3	3	2	3	3	1	1	2	3	1	5	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:89068364C>T	uc003yeb.3	-	8	1647	c.1365G>A	c.(1363-1365)AAG>AAA	p.K455K		NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	455	Extracellular (Potential).|Hemopexin-like 3.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						ACCTGTCTCCCTTGAAGAAAT	0.418													23	105					0	0	0	0	T	89068364	T	T	89068364	2	4	294	1	0	0	0	0	0	0	0	1	9708	680	24	4		4	MMP16	8	89068364	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1826088	89068364	57295658	176	54177											
RUNX1T1	862	broad.mit.edu	37	chr8	92998475	92998475	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccagtaattcaattcttcccGgtctgcttcttgacaccgcc	7	13	6	15	2	4	1	1	1	3	0	5	1	5	1	4	1	1	2	4	1	2	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:92998475G>T	uc003yfd.2	-	8	1240	c.1156C>A	c.(1156-1158)CGG>AGG	p.R386R	RUNX1T1_uc003yfc.1_Silent_p.R359R|RUNX1T1_uc003yfe.1_Silent_p.R349R|RUNX1T1_uc010mao.2_Silent_p.R359R|RUNX1T1_uc011lgi.1_Silent_p.R397R|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Silent_p.R349R	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	386			R -> W (in a colorectal cancer sample; somatic mutation).		generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R349W(1)		lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			AATTCTTCCCGGTCTGCTTCT	0.498													28	116					1.16021e-09	1.37856e-09	1	0	T	92998475	T	T	92998475	2	4	294	1	0	0	0	0	0	0	0	1	13812	1115	39	3		3	RUNX1T1	8	92998475	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3930111	92998475	53365547	177	54178											
POP1	10940	broad.mit.edu	37	chr8	99152363	99152363	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ggatagaaacctgtaagaaaCctgacagcgtttcccttcat	13	10	8	10	1	1	3	1	1	0	2	2	4	2	4	3	1	3	2	3	1	4	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:99152363C>T	uc003yij.3	+	10	1520	c.1420C>T	c.(1420-1422)CCT>TCT	p.P474S	POP1_uc011lgv.1_Missense_Mutation_p.P474S|POP1_uc003yik.2_Missense_Mutation_p.P474S	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	474					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			CTGTAAGAAACCTGACAGCGT	0.488													8	37					0	0	0	0	T	99152363	T	T	99152363	3	4	294	1	0	0	0	0	1	0	0	0	12306	507	18	4	1454	4	POP1	8	99152363	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	6153888	99152363	47211659	178	54179											
RIMS2	9699	broad.mit.edu	37	chr8	105160975	105160975	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cactgcagtgggcaccttggGcaccagtggcaaaaagcggc	10	5	14	12	1	0	0	0	0	0	0	0	0	0	0	2	4	2	4	2	4	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:105160975G>A	uc003yls.2	+	23	3528	c.3287G>A	c.(3286-3288)GGC>GAC	p.G1096D	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.G1085D|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGCACCTTGGGCACCAGTGGC	0.532										HNSCC(12;0.0054)			22	57					0	0	0	0	A	105160975	A	A	105160975	3	1	294	1	0	0	0	0	1	0	0	0	13433	1218	42	4		4	RIMS2	8	105160975	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	6008612	105160975	41203047	179	54180											
PLEC	5339	broad.mit.edu	37	chr8	144993365	144993365	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttctccgcccctttcagtgGcagaaggcgcaagcccgtct	6	9	10	16	3	3	1	1	0	2	1	4	1	3	1	4	2	1	2	4	2	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr8:144993365G>A	uc003zaf.1	-	32	11205	c.11035C>T	c.(11035-11037)CCA>TCA	p.P3679S	PLEC_uc003zab.1_Missense_Mutation_p.P3542S|PLEC_uc003zac.1_Missense_Mutation_p.P3546S|PLEC_uc003zad.2_Missense_Mutation_p.P3542S|PLEC_uc003zae.1_Missense_Mutation_p.P3510S|PLEC_uc003zag.1_Missense_Mutation_p.P3520S|PLEC_uc003zah.2_Missense_Mutation_p.P3528S|PLEC_uc003zaj.2_Missense_Mutation_p.P3569S	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3679	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCTTTCAGTGGCAGAAGGCGC	0.592													70	172					0	0	0	0	A	144993365	A	A	144993365	3	1	294	1	0	0	0	0	1	0	0	0	12107	1203	42	4	3023	4	PLEC	8	144993365	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	39832390	144993365	1370657	180	54181											
LINGO2	158038	broad.mit.edu	37	chr9	27949577	27949577	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggctgtcgctgcaagatccAgagaaggcggcagtcacagg	10	5	16	10	2	1	2	1	0	0	2	3	3	2	2	1	4	1	4	1	4	2	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr9:27949577A>C	uc003zqu.1	-	2	1287	c.1093T>G	c.(1093-1095)TGG>GGG	p.W365G	LINGO2_uc010mjf.1_Missense_Mutation_p.W365G|LINGO2_uc003zqv.1_Missense_Mutation_p.W365G	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	365	LRRCT.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TGCAAGATCCAGAGAAGGCGG	0.547													8	27					0	0	0	0	C	27949577	C	C	27949577	3	2	294	1	0	0	0	0	1	0	0	0	8857	188	7	5	731	5	LINGO2	9	27949577	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08		27949577	113263854	181	54182											
PRKACG	5568	broad.mit.edu	37	chr9	71628059	71628059	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccagggcctgtgtacttcGggatgaagggagcttccacc	7	8	13	13	1	0	1	0	1	0	0	2	3	1	3	5	3	2	2	5	3	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr9:71628059G>A	uc004agy.2	-	1	981	c.950C>T	c.(949-951)CCG>CTG	p.P317L		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	317	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						TGTGTACTTCGGGATGAAGGG	0.532													21	62					0	0	0	0	A	71628059	A	A	71628059	3	1	294	1	0	0	0	0	1	0	0	0	12561	1116	39	1	109	1	PRKACG	9	71628059	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	43678482	71628059	69585372	182	54183											
FLJ46321	389763	broad.mit.edu	37	chr9	84607188	84607188	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctattcctgattaggatCtgtggagtgtgttttcatag	7	17	10	7	0	3	1	1	1	2	0	4	3	4	3	2	2	0	1	2	2	3	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr9:84607188C>A	uc004amn.2	+	4	1850	c.1803C>A	c.(1801-1803)ATC>ATA	p.I601I		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	601						integral to membrane					0						TGATTAGGATCTGTGGAGTGT	0.498													17	83					2.32416e-17	3.16115e-17	1	0	A	84607188	A	A	84607188	2	1	294	1	0	0	0	0	0	0	0	1	5964	903	32	2		2	FLJ46321	9	84607188	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	12979129	84607188	56606243	183	54184											
RASEF	158158	broad.mit.edu	37	chr9	85611940	85611940	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcttacctcaatcatatctAcccattctcgtatgttaaga	11	16	3	11	1	5	1	2	0	3	1	6	1	5	1	2	0	2	2	2	0	6	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr9:85611940A>C	uc004amo.1	-	14	2168	c.1907T>G	c.(1906-1908)GTA>GGA	p.V636G		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	636					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						AATCATATCTACCCATTCTCG	0.368													17	54					0	0	0	0	C	85611940	C	C	85611940	3	2	294	1	0	0	0	0	1	0	0	0	13133	391	14	5	331	5	RASEF	9	85611940	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	1004752	85611940	55601491	184	54185											
HIATL1	84641	broad.mit.edu	37	chr9	97218571	97218571	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccatgtccagcatcacgtttCcggcaatcagtgccctcgtc	7	10	8	16	3	2	0	2	0	0	0	6	0	4	0	4	1	2	3	4	1	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr9:97218571C>A	uc004aur.2	+	10	1347	c.1078C>A	c.(1078-1080)CCG>ACG	p.P360T	HIATL1_uc011luh.1_Intron	NM_032558	NP_115947	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	360	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				CATCACGTTTCCGGCAATCAG	0.577													34	116					5.43694e-19	7.61531e-19	1	0	A	97218571	A	A	97218571	3	1	294	1	0	0	0	0	1	0	0	0	7137	855	30	2	1116	2	HIATL1	9	97218571	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	11606631	97218571	43994860	185	54186											
NTNG2	84628	broad.mit.edu	37	chr9	135073847	135073847	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atggacaacctctacacgcgGctggagagcgccaagggcct	10	5	13	13	3	1	1	0	0	1	1	1	3	1	2	3	4	3	1	3	4	3	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr9:135073847G>A	uc004cbh.2	+	3	1484	c.708G>A	c.(706-708)CGG>CGA	p.R236R		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	236	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		TCTACACGCGGCTGGAGAGCG	0.667													36	107					0	0	0	0	A	135073847	A	A	135073847	2	1	294	1	0	0	0	0	0	0	0	1	10759	1190	42	4		4	NTNG2	9	135073847	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	37855276	135073847	6139584	186	54187											
RXRA	6256	broad.mit.edu	37	chr9	137293688	137293688	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cccccactccatgtcggtgcCcaccacacccaccctgggct	6	6	7	22	1	0	0	0	0	0	0	2	0	1	0	7	2	1	1	7	2	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr9:137293688C>A	uc004cfb.2	+	2	401	c.239C>A	c.(238-240)CCC>CAC	p.P80H	RXRA_uc004cfa.1_Silent_p.A130A	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	80	Modulating (By similarity).				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	ATGTCGGTGCCCACCACACCC	0.498													24	99					4.72057e-08	5.44088e-08	1	0	A	137293688	A	A	137293688	3	1	294	1	0	0	0	0	1	0	0	0	13828	623	22	4	245	4	RXRA	9	137293688	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2219841	137293688	3919743	187	54188											
ANAPC2	29882	broad.mit.edu	37	chr9	140074693	140074693	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccctgatatcctcggggacCtccagcttctcgtccttgaa	6	11	9	15	2	1	2	0	2	1	0	6	3	4	3	5	2	1	1	5	2	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr9:140074693C>G	uc004clr.1	-	10	1903	c.1830G>C	c.(1828-1830)GAG>GAC	p.E610D	ANAPC2_uc004clq.1_Missense_Mutation_p.E466D	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	610					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		CCTCGGGGACCTCCAGCTTCT	0.612													20	76					0	0	0	0	G	140074693	G	G	140074693	3	3	294	1	0	0	0	0	1	0	0	0	603	680	24	4	654	4	ANAPC2	9	140074693	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2781005	140074693	1138738	188	54189											
EHMT1	79813	broad.mit.edu	37	chr9	140611227	140611228	+	Frame_Shift_Ins	INS	-	T	T																															cactcaggacagcgcaagggINStcaacccccaggatggcacc																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr9:140611227_140611228insT	uc011mfc.1	+	3	272_273	c.235_236insT	c.(235-237)GTCfs	p.V79fs	EHMT1_uc004coa.2_Frame_Shift_Ins_p.V79fs|EHMT1_uc004cob.1_Frame_Shift_Ins_p.V48fs	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	79					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CAGCGCAAGGGTCAACCCCCAG	0.554													---	---	---								T	140611228	T	T	140611227	7	5	294	1	0	1	1	0	0	0	0	0	5005	1261	44	0	245	0	EHMT1	9	140611227	Frame_Shift_Ins	INS	-	TCGA-DQ-7595-01A-11D-2229-08	536534	140611227	602204	189	54190											
PRKCQ	5588	broad.mit.edu	37	chr10	6540446	6540446	+	Frame_Shift_Del	DEL	C	-	-																															cttgacgtggtggacctttgCctgcttgatggcaccccggc																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:6540446delC	uc001ijj.1	-	5	529	c.454delG	c.(454-456)GCAfs	p.A152fs	PRKCQ_uc009xim.1_Frame_Shift_Del_p.A152fs|PRKCQ_uc001iji.1_Frame_Shift_Del_p.A185fs|PRKCQ_uc009xin.1_Frame_Shift_Del_p.A116fs|PRKCQ_uc010qax.1_Frame_Shift_Del_p.A27fs	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	152					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						TGGACCTTTGCCTGCTTGATG	0.512													---	---	---								-	6540446	-	-	6540446	7	5	294	1	0	1	0	1	0	0	0	0	12577	739	26	0	1722	0	PRKCQ	10	6540446	Frame_Shift_Del	DEL	C	TCGA-DQ-7595-01A-11D-2229-08		6540446	128994301	190	54191											
ITIH5	80760	broad.mit.edu	37	chr10	7683946	7683946	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatctggaactcaatgtcCtggtcttcagaagctctgtt	8	14	9	10	0	5	1	2	0	3	1	6	2	6	2	1	2	3	3	1	2	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:7683946C>T	uc001ijq.2	-	3	322	c.243G>A	c.(241-243)CAG>CAA	p.Q81Q	ITIH5_uc001ijr.1_Silent_p.Q81Q	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	81	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						ACTCAATGTCCTGGTCTTCAG	0.468													29	98					0	0	0	0	T	7683946	T	T	7683946	2	4	294	1	0	0	0	0	0	0	0	1	7946	680	24	4		4	ITIH5	10	7683946	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1143500	7683946	127850801	191	54192											
CUBN	8029	broad.mit.edu	37	chr10	17145223	17145223	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cttccatttattcctgagagGgactctccacaaactgcaaa	12	11	6	12	0	1	1	0	1	1	1	4	3	3	2	3	1	2	1	3	1	3	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:17145223G>A	uc001ioo.2	-	13	1483	c.1431C>T	c.(1429-1431)TCC>TCT	p.S477S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	477	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTCCTGAGAGGGACTCTCCAC	0.438													12	43					0	0	0	0	A	17145223	A	A	17145223	2	1	294	1	0	0	0	0	0	0	0	1	4068	1219	43	4		4	CUBN	10	17145223	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	9461277	17145223	118389524	192	54193											
GPR158	57512	broad.mit.edu	37	chr10	25701259	25701259	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctgcctaccttgcagggagGgctgccccttctgtgctgat	4	12	12	13	0	2	1	0	1	2	0	2	2	2	2	4	2	5	3	4	2	1	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:25701259G>T	uc001isj.2	+	4	1252	c.1192G>T	c.(1192-1194)GGC>TGC	p.G398C		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	398	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TTGCAGGGAGGGCTGCCCCTT	0.488													65	178					8.09925e-49	1.25955e-48	1	0	T	25701259	T	T	25701259	3	4	294	1	0	0	0	0	1	0	0	0	6701	1232	43	4	1206	4	GPR158	10	25701259	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	8556036	25701259	109833488	193	54194											
PARD3	56288	broad.mit.edu	37	chr10	34739281	34739281	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agccacttgcccaccattggGtgactggcactcagagacga	10	7	11	13	1	1	2	1	1	0	1	1	4	1	2	3	2	2	1	3	2	0	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:34739281G>A	uc010qej.1	-	5	678	c.678C>T	c.(676-678)CAC>CAT	p.H226H	PARD3_uc010qek.1_Silent_p.H226H|PARD3_uc010qel.1_Silent_p.H226H|PARD3_uc010qem.1_Silent_p.H226H|PARD3_uc010qen.1_Silent_p.H226H|PARD3_uc010qeo.1_Silent_p.H226H|PARD3_uc010qep.1_Intron|PARD3_uc010qeq.1_Intron|PARD3_uc001ixp.1_Silent_p.H91H|PARD3_uc001ixq.1_Silent_p.H226H|PARD3_uc001ixr.1_Silent_p.H226H|PARD3_uc001ixt.1_Intron|PARD3_uc001ixu.1_Intron	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	226					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CCACCATTGGGTGACTGGCAC	0.463													34	94					0	0	0	0	A	34739281	A	A	34739281	2	1	294	1	0	0	0	0	0	0	0	1	11497	1252	44	4		4	PARD3	10	34739281	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	9038022	34739281	100795466	194	54195											
ZNF239	8187	broad.mit.edu	37	chr10	44053168	44053168	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agttcttgtccatcagacacCagtttaacttgaaggttctc	10	14	7	10	0	3	2	1	1	2	1	5	2	4	2	2	1	1	3	2	1	2	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:44053168C>A	uc001jaw.3	-	2	1013	c.360G>T	c.(358-360)CTG>CTT	p.L120L	ZNF239_uc001jax.3_Silent_p.L120L|ZNF239_uc009xmj.2_Silent_p.L120L|ZNF239_uc009xmk.2_Silent_p.L120L	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						CATCAGACACCAGTTTAACTT	0.428													21	58					2.4624e-09	2.90138e-09	1	0	A	44053168	A	A	44053168	2	1	294	1	0	0	0	0	0	0	0	1	17858	581	21	4		4	ZNF239	10	44053168	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	9313887	44053168	91481579	195	54196											
TMEM72	643236	broad.mit.edu	37	chr10	45429211	45429211	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccggtcctggtctggcaCgtgaccatcccaggtaagag	8	7	12	14	2	1	2	0	1	1	1	3	2	3	2	4	4	0	2	4	4	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:45429211C>A	uc001jbn.2	+	4	533	c.336C>A	c.(334-336)CAC>CAA	p.H112Q	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_5'UTR	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	112	Helical; (Potential).					integral to membrane					0						TGGTCTGGCACGTGACCATCC	0.607													25	55					7.07758e-08	8.02632e-08	1	0	A	45429211	A	A	45429211	3	1	294	1	0	0	0	0	1	0	0	0	16267	535	19	3	350	3	TMEM72	10	45429211	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1376043	45429211	90105536	196	54197											
ARID5B	84159	broad.mit.edu	37	chr10	63852352	63852352	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccaaggaggtctctgggaagGagaaggcctctgagcaggag	11	5	17	8	0	2	2	0	1	2	1	3	6	2	5	2	6	1	1	2	6	3	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:63852352G>T	uc001jlt.1	+	10	3156	c.3130G>T	c.(3130-3132)GAG>TAG	p.E1044*		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1044					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CTCTGGGAAGGAGAAGGCCTC	0.602													25	65					9.86323e-18	1.35459e-17	1	0	T	63852352	T	T	63852352	4	4	294	1	0	0	0	0	0	1	0	0	922	1175	41	2	3168	2	ARID5B	10	63852352	Nonsense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	18423141	63852352	71682395	197	54198											
C10orf27	219793	broad.mit.edu	37	chr10	72541663	72541663	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggggtttggggctttggggtCctcaatgcccggcggatccg	3	10	18	10	3	1	0	1	0	0	0	3	1	3	1	3	8	1	2	3	8	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:72541663C>A	uc001jrj.1	-	4	561	c.171G>T	c.(169-171)AGG>AGT	p.R57S	C10orf27_uc010qjm.1_Missense_Mutation_p.R57S|C10orf27_uc009xqh.1_RNA|C10orf27_uc010qjn.1_Missense_Mutation_p.R57S|C10orf27_uc009xqi.1_RNA|C10orf27_uc010qjo.1_Missense_Mutation_p.R46S|C10orf27_uc009xqj.1_Missense_Mutation_p.R46S|C10orf27_uc010qjp.1_Missense_Mutation_p.R46S	NM_152710	NP_689923	Q96M53	SPATL_HUMAN	stromal protein associated with thymii and lymph	57					cell differentiation|multicellular organismal development|spermatogenesis	cytosol				skin(1)	1						GCTTTGGGGTCCTCAATGCCC	0.622													41	145					1.03325e-14	1.34481e-14	1	0	A	72541663	A	A	72541663	3	1	294	1	0	0	0	0	1	0	0	0	1606	854	30	2	916	2	C10orf27	10	72541663	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	8689311	72541663	62993084	198	54199											
RNLS	55328	broad.mit.edu	37	chr10	90122434	90122434	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggcccagagcatatcgaGaggagtagctcacagcctcc	12	5	12	12	1	1	3	1	0	0	3	3	5	2	4	3	2	3	3	3	2	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:90122434G>T	uc001kfe.2	-	5	710	c.575C>A	c.(574-576)TCT>TAT	p.S192Y	RNLS_uc010qms.1_Missense_Mutation_p.S109Y|RNLS_uc001kfd.2_Missense_Mutation_p.S192Y|RNLS_uc009xtj.2_Missense_Mutation_p.S24Y	NM_001031709	NP_001026879	Q5VYX0	RNLS_HUMAN	renalase isoform 1	192						extracellular region	oxidoreductase activity			ovary(1)	1						AGCATATCGAGAGGAGTAGCT	0.448													17	50					2.48551e-13	3.15726e-13	1	0	T	90122434	T	T	90122434	3	4	294	1	0	0	0	0	1	0	0	0	13570	942	33	2	541	2	RNLS	10	90122434	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	17580771	90122434	45412313	199	54200											
KIF11	3832	broad.mit.edu	37	chr10	94369264	94369264	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	actctgatgaatgcatactcTaggtaagaaagccatagtct	14	11	8	8	0	3	3	0	2	3	1	3	3	3	3	1	1	3	2	1	1	6	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:94369264T>C	uc001kic.2	+	6	1004	c.696T>C	c.(694-696)TCT>TCC	p.S232S	KIF11_uc010qnq.1_Intron	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	232	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1						ATGCATACTCTAGGTAAGAAA	0.408													91	213					0	0	0	0	C	94369264	C	C	94369264	2	2	294	1	0	0	0	0	0	0	0	1	8311	1509	53	5		5	KIF11	10	94369264	Silent	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	4246830	94369264	41165483	200	54201											
VWA2	340706	broad.mit.edu	37	chr10	116049132	116049132	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cttggtcgtgggcgtggggcCtgtcctaagtgagggtctgc	3	11	18	9	2	1	1	0	1	1	0	3	1	2	1	2	5	1	0	2	5	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:116049132C>A	uc001lbl.1	+	12	2327	c.2006C>A	c.(2005-2007)CCT>CAT	p.P669H	VWA2_uc001lbk.1_Missense_Mutation_p.P669H|VWA2_uc009xyf.1_Missense_Mutation_p.P365H	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	669	VWFA 3.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		GGCGTGGGGCCTGTCCTAAGT	0.632													34	84					8.73648e-17	1.17692e-16	1	0	A	116049132	A	A	116049132	3	1	294	1	0	0	0	0	1	0	0	0	17307	681	24	4	2048	4	VWA2	10	116049132	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	21679868	116049132	19485615	201	54202											
KCNK18	338567	broad.mit.edu	37	chr10	118960766	118960766	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtccttcctgagctcgcTctttttctgctgcacggtgt	2	16	10	13	2	2	1	0	1	2	0	5	1	4	1	2	2	3	4	2	2	0	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:118960766T>A	uc010qsr.1	+	2	320	c.320T>A	c.(319-321)CTC>CAC	p.L107H		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	107						integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CTGAGCTCGCTCTTTTTCTGC	0.567													41	77					0	0	0	0	A	118960766	A	A	118960766	3	1	294	1	0	0	0	0	1	0	0	0	8104	1551	54	5	326	5	KCNK18	10	118960766	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	2911634	118960766	16573981	202	54203											
EBF3	253738	broad.mit.edu	37	chr10	131666137	131666137	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtggcaccccccgtggtcCagccttcactgggactgatg	5	8	13	15	2	1	1	1	1	0	0	2	2	2	2	5	4	1	1	5	4	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:131666137C>T	uc001lki.1	-	9	853	c.794G>A	c.(793-795)TGG>TAG	p.W265*		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	274	IPT/TIG.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding	p.W265C(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCCCGTGGTCCAGCCTTCACT	0.587													20	93					0	0	0	0	T	131666137	T	T	131666137	4	4	294	1	0	0	0	0	0	1	0	0	4904	595	21	4	893	4	EBF3	10	131666137	Nonsense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	12705371	131666137	3868610	203	54204											
KNDC1	85442	broad.mit.edu	37	chr10	135015300	135015300	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcagccccggctggtgcagCgccttctacgaggccgactg	5	7	14	15	4	1	0	0	0	1	0	1	2	1	0	4	3	5	3	4	3	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr10:135015300C>A	uc001llz.1	+	17	3286	c.3285C>A	c.(3283-3285)AGC>AGA	p.S1095R	KNDC1_uc001lma.1_Missense_Mutation_p.S1030R|KNDC1_uc001lmb.1_Missense_Mutation_p.S507R	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1095					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GCTGGTGCAGCGCCTTCTACG	0.716													4	11					1.024e-07	1.15816e-07	1	0	A	135015300	A	A	135015300	3	1	294	1	0	0	0	0	1	0	0	0	8465	767	27	3	3351	3	KNDC1	10	135015300	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3349163	135015300	519447	204	54205											
OR52N2	390077	broad.mit.edu	37	chr11	5842439	5842439	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tactgcctcctaccatgaacCcaattgtttatggagtcaag	11	12	7	11	0	1	1	1	1	0	0	2	2	2	2	4	1	4	1	4	1	6	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:5842439C>A	uc010qzp.1	+	1	874	c.874C>A	c.(874-876)CCA>ACA	p.P292T	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACCATGAACCCAATTGTTTA	0.378													22	90					4.4004e-07	4.88549e-07	1	0	A	5842439	A	A	5842439	3	1	294	1	0	0	0	0	1	0	0	0	11182	623	22	4	876	4	OR52N2	11	5842439	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08		5842439	129164077	205	54206											
OR56A5	390084	broad.mit.edu	37	chr11	5988829	5988829	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ttccctgcttgatctccttgGttctcacaccataaacaatg	9	14	5	13	0	2	1	1	1	2	0	5	1	3	1	3	1	2	2	3	1	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:5988829G>C	uc010qzu.1	-	1	896	c.896C>G	c.(895-897)ACC>AGC	p.T299S		NM_001146033	NP_001139505	P0C7T3	O56A5_HUMAN	olfactory receptor, family 56, subfamily A,	299	Cytoplasmic (Potential).					integral to membrane|plasma membrane	olfactory receptor activity				0						GATCTCCTTGGTTCTCACACC	0.458													11	18					0	0	0	0	C	5988829	C	C	5988829	3	2	294	1	0	0	0	0	1	0	0	0	11190	1261	44	4	47	4	OR56A5	11	5988829	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	146390	5988829	129017687	206	54207											
OR52L1	338751	broad.mit.edu	37	chr11	6007720	6007720	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggattgtggaatggtgcaaGgggtgacaaatggctacata	13	9	15	4	0	0	1	0	1	0	0	0	3	0	3	0	6	2	2	0	6	5	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:6007720G>T	uc001mcd.2	-	1	496	c.441C>A	c.(439-441)CCC>CCA	p.P147P		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	147	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AATGGTGCAAGGGGTGACAAA	0.517													14	54					3.99206e-14	5.14829e-14	1	0	T	6007720	T	T	6007720	2	4	294	1	0	0	0	0	0	0	0	1	11179	987	35	4		4	OR52L1	11	6007720	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	18891	6007720	128998796	207	54208											
CCKBR	887	broad.mit.edu	37	chr11	6290966	6290966	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgagcgttggaggaaatatGctcatcatcgtggtcctggg	9	11	14	7	2	2	1	2	1	0	0	4	3	3	3	1	4	2	2	1	4	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:6290966G>A	uc001mcp.2	+	2	412	c.219G>A	c.(217-219)ATG>ATA	p.M73I	CCKBR_uc001mcq.2_Missense_Mutation_p.M1I|CCKBR_uc001mcr.2_Missense_Mutation_p.M73I|CCKBR_uc001mcs.2_Missense_Mutation_p.M73I	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	73	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GAGGAAATATGCTCATCATCG	0.552													39	136					0	0	0	0	A	6290966	A	A	6290966	3	1	294	1	0	0	0	0	1	0	0	0	2894	1319	46	4	225	4	CCKBR	11	6290966	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	283246	6290966	128715550	208	54209											
DCHS1	8642	broad.mit.edu	37	chr11	6651019	6651019	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcgcctcgtcgttgacgtcaGcgacactgacggtcaggacc	7	7	13	14	6	2	2	2	2	0	0	4	4	2	3	2	2	1	1	2	2	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:6651019G>T	uc001mem.1	-	11	5329	c.4919C>A	c.(4918-4920)GCT>GAT	p.A1640D		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1640	Cadherin 15.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTTGACGTCAGCGACACTGAC	0.632													22	57					2.89027e-11	3.56438e-11	1	0	T	6651019	T	T	6651019	3	4	294	1	0	0	0	0	1	0	0	0	4304	971	34	4	5021	4	DCHS1	11	6651019	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	360053	6651019	128355497	209	54210											
INSC	387755	broad.mit.edu	37	chr11	15134052	15134052	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatggagaggcggccagcGaaggtccaggtggctggggt	8	5	20	8	2	0	1	0	0	0	1	1	3	1	1	2	8	1	2	2	8	2	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:15134052G>T	uc001mly.2	+	1	83	c.37G>T	c.(37-39)GAA>TAA	p.E13*	INSC_uc001mlz.2_5'Flank	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	13					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						GGCGGCCAGCGAAGGTCCAGG	0.552													19	64					3.5997e-14	4.65649e-14	1	0	T	15134052	T	T	15134052	4	4	294	1	0	0	0	0	0	1	0	0	7803	1059	37	3	39	3	INSC	11	15134052	Nonsense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	8483033	15134052	119872464	210	54211											
KCNA4	3739	broad.mit.edu	37	chr11	30032839	30032839	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggcccaggatctgcaggcCtttggagtgcctggagagtt	6	10	16	9	0	1	1	0	0	1	1	1	4	1	3	3	5	2	2	3	5	0	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:30032839C>A	uc001msk.2	-	2	2539	c.1387G>T	c.(1387-1389)GGC>TGC	p.G463C		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	463						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ATCTGCAGGCCTTTGGAGTGC	0.542													17	62					2.48551e-13	3.15726e-13	1	0	A	30032839	A	A	30032839	3	1	294	1	0	0	0	0	1	0	0	0	8044	681	24	4	578	4	KCNA4	11	30032839	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	14898787	30032839	104973677	211	54212											
OR5D18	219438	broad.mit.edu	37	chr11	55587449	55587449	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtggtcactgaatccttttTattagctgtgatggcctatg	7	17	10	7	0	1	2	1	2	0	0	2	2	2	2	2	2	1	1	2	2	4	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:55587449T>C	uc010rin.1	+	1	344	c.344T>C	c.(343-345)TTA>TCA	p.L115S		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GAATCCTTTTTATTAGCTGTG	0.438													44	140					0	0	0	0	C	55587449	C	C	55587449	3	2	294	1	0	0	0	0	1	0	0	0	11211	1764	61	5	346	5	OR5D18	11	55587449	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	25554610	55587449	79419067	212	54213											
OR10AG1	282770	broad.mit.edu	37	chr11	55735761	55735761	+	Frame_Shift_Del	DEL	A	-	-																															ttgttacataacagatttccAaaagggaaaaattgctaaga																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:55735761delA	uc010rit.1	-	1	179	c.179delT	c.(178-180)TTGfs	p.L60fs		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					ACAGATTTCCAAAAGGGAAAA	0.353													---	---	---								-	55735761	-	-	55735761	7	5	294	1	0	1	0	1	0	0	0	0	10951	131	5	0	729	0	OR10AG1	11	55735761	Frame_Shift_Del	DEL	A	TCGA-DQ-7595-01A-11D-2229-08	148312	55735761	79270755	213	54214											
OR4D11	219986	broad.mit.edu	37	chr11	59271673	59271673	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaatggcctggtcactaccCtgtggtttatcttcctgctt	6	15	8	12	0	2	0	1	0	1	0	3	0	3	0	3	3	2	2	3	3	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:59271673C>A	uc001noa.1	+	1	625	c.625C>A	c.(625-627)CTG>ATG	p.L209M		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGTCACTACCCTGTGGTTTAT	0.512													23	98					0.000117367	0.000124739	1	0	A	59271673	A	A	59271673	3	1	294	1	0	0	0	0	1	0	0	0	11109	680	24	4	627	4	OR4D11	11	59271673	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3535912	59271673	75734843	214	54215											
PLAC1L	219990	broad.mit.edu	37	chr11	59814417	59814417	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tctgtttcccttttctttagGaaatcagtgtggcttacacc	7	17	7	10	0	3	0	1	0	2	0	4	1	4	1	2	2	1	2	2	2	3	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:59814417G>A	uc001nol.2	+	4	533	c.348G>A	c.(346-348)AGG>AGA	p.R116R		NM_173801	NP_776162	Q86WS3	PLACL_HUMAN	placenta-specific 1-like precursor	116						extracellular region				ovary(2)|skin(1)	3						TTTTCTTTAGGAAATCAGTGT	0.363													36	133					0	0	0	0	A	59814417	A	A	59814417	2	1	294	1	0	0	0	0	0	0	0	1	12068	1188	41	2		2	PLAC1L	11	59814417	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	542744	59814417	75192099	215	54216											
NRXN2	9379	broad.mit.edu	37	chr11	64421183	64421183	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttactgggtgcgcagccgaCgcgcaggcagtctggggggg	5	6	19	11	4	1	0	0	0	1	0	1	1	1	0	1	5	3	3	1	5	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:64421183C>A	uc001oar.2	-	13	2840	c.2401G>T	c.(2401-2403)GTC>TTC	p.V801F	NRXN2_uc001oas.2_Intron|NRXN2_uc001oaq.2_Missense_Mutation_p.V468F	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GCGCAGCCGACGCGCAGGCAG	0.577													3	13					0.00024832	0.000259998	1	0	A	64421183	A	A	64421183	3	1	294	1	0	0	0	0	1	0	0	0	10720	536	19	3	3054	3	NRXN2	11	64421183	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	4606766	64421183	70585333	216	54217											
RASGRP2	10235	broad.mit.edu	37	chr11	64502700	64502700	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaaagttccggaacacagaCtggggcacgcagagggacac	13	4	13	11	2	1	2	1	0	0	2	2	4	2	4	1	4	1	3	1	4	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:64502700C>T	uc009ypu.2	-	12	1524	c.1297_splice	c.e12-1	p.S433_splice	RASGRP2_uc001oat.2_Splice_Site_p.S335_splice|RASGRP2_uc001oau.2_Splice_Site_p.S288_splice|RASGRP2_uc009ypv.2_Splice_Site_p.S433_splice|RASGRP2_uc009ypw.2_Splice_Site_p.S433_splice	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2						platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						GGAACACAGACTGGGGCACGC	0.567													9	45					0	0	0	0	T	64502700	T	T	64502700	5	4	294	1	0	0	0	0	0	0	1	0	13140	579	20	4	553	4	RASGRP2	11	64502700	Splice_Site	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	81517	64502700	70503816	217	54218											
LRTOMT	220074	broad.mit.edu	37	chr11	71804597	71804597	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccactgaagcgttcaaagtcGgggaaatcactgacccagtc	12	7	10	12	2	2	2	2	2	0	0	4	3	2	3	2	2	1	1	2	2	3	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:71804597G>A	uc001orr.2	+	4	516	c.138G>A	c.(136-138)TCG>TCA	p.S46S	LRTOMT_uc009ysz.2_RNA|LRTOMT_uc010rqt.1_Silent_p.S46S|LRTOMT_uc010rqu.1_Silent_p.S28S|LRTOMT_uc009yta.2_Intron|LRTOMT_uc010rqv.1_5'UTR|LRTOMT_uc010rqw.1_5'UTR|LRTOMT_uc001ors.3_5'UTR|LRTOMT_uc010rqs.1_Silent_p.S46S	NM_145309	NP_660352	Q96E66	LRC51_HUMAN	leucine rich transmembrane and	46						cytoplasm					0						GTTCAAAGTCGGGGAAATCAC	0.488													8	37					0	0	0	0	A	71804597	A	A	71804597	2	1	294	1	0	0	0	0	0	0	0	1	9096	1103	39	1		1	LRTOMT	11	71804597	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	7301897	71804597	63201919	218	54219											
P2RY6	5031	broad.mit.edu	37	chr11	73008014	73008014	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggctagtgtgtgtagccGtgtggctggccgtgacaacc	5	10	15	11	2	0	1	0	1	0	0	0	1	0	1	4	3	2	3	4	3	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:73008014G>A	uc001otm.2	+	4	856	c.451G>A	c.(451-453)GTG>ATG	p.V151M	P2RY6_uc001otn.2_Missense_Mutation_p.V151M|P2RY6_uc001oto.2_Missense_Mutation_p.V151M|P2RY6_uc001otp.2_Missense_Mutation_p.V151M|P2RY6_uc001otq.2_Missense_Mutation_p.V151M|P2RY6_uc001otr.2_Missense_Mutation_p.V151M|P2RY6_uc001ots.2_Missense_Mutation_p.V151M	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	151	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						GTGTGTAGCCGTGTGGCTGGC	0.667													28	73					0	0	0	0	A	73008014	A	A	73008014	3	1	294	1	0	0	0	0	1	0	0	0	11408	1145	40	1	453	1	P2RY6	11	73008014	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1203417	73008014	61998502	219	54220											
ANKRD49	54851	broad.mit.edu	37	chr11	94231288	94231288	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aggccactcacgtgaacactAgggatgaagatgagtatacc	14	7	11	9	1	1	4	1	3	0	1	1	5	1	5	2	2	2	1	2	2	5	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:94231288A>G	uc001pew.2	+	3	449	c.310A>G	c.(310-312)AGG>GGG	p.R104G	ANKRD49_uc001pex.2_3'UTR|ANKRD49_uc001pey.2_RNA	NM_017704	NP_060174	Q8WVL7	ANR49_HUMAN	fetal globin inducing factor	104					positive regulation of transcription, DNA-dependent					central_nervous_system(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CGTGAACACTAGGGATGAAGA	0.448													14	46					0	0	0	0	G	94231288	G	G	94231288	3	3	294	1	0	0	0	0	1	0	0	0	675	411	15	5	316	5	ANKRD49	11	94231288	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	21223274	94231288	40775228	220	54221											
PGR	5241	broad.mit.edu	37	chr11	100920717	100920717	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcttcttggctaacttgaaGcttgacaaactcctgtggga	9	13	9	10	0	2	2	0	2	2	0	3	3	3	3	1	2	3	2	1	2	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:100920717G>T	uc001pgh.2	-	6	3174	c.2431C>A	c.(2431-2433)CTT>ATT	p.L811I	PGR_uc001pgg.2_Missense_Mutation_p.L192I|PGR_uc001pgi.2_Missense_Mutation_p.L709I|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	811	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CTAACTTGAAGCTTGACAAAC	0.368													16	51					3.32936e-07	3.7061e-07	1	0	T	100920717	T	T	100920717	3	4	294	1	0	0	0	0	1	0	0	0	11860	971	34	4	382	4	PGR	11	100920717	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	6689429	100920717	34085799	221	54222											
NPAT	4863	broad.mit.edu	37	chr11	108057265	108057265	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtattgttgaatgagggcCagacaaagtggtactttttc	10	13	11	7	1	0	3	0	2	0	1	1	3	0	3	2	2	1	3	2	2	4	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:108057265C>T	uc001pjz.3	-	8	772	c.670G>A	c.(670-672)GGC>AGC	p.G224S	NPAT_uc001pka.2_Missense_Mutation_p.G19S	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	224	Interaction with MIZF.				positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		GAATGAGGGCCAGACAAAGTG	0.323													17	63					0	0	0	0	T	108057265	T	T	108057265	3	4	294	1	0	0	0	0	1	0	0	0	10620	594	21	4	3657	4	NPAT	11	108057265	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	7136548	108057265	26949251	222	54223											
LAYN	143903	broad.mit.edu	37	chr11	111428319	111428319	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagcattccccttctcctcCtccttgtggtcaccacagtt	5	13	5	18	0	2	0	1	0	1	0	6	0	5	0	7	1	1	2	7	1	0	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:111428319C>T	uc001plr.1	+	7	1072	c.736C>T	c.(736-738)CTC>TTC	p.L246F	LAYN_uc001plp.1_Missense_Mutation_p.L238F|LAYN_uc001plq.1_Missense_Mutation_p.L246F|LAYN_uc001pls.1_Missense_Mutation_p.L238F|LAYN_uc010rwg.1_Missense_Mutation_p.L93F|LAYN_uc010rwh.1_Missense_Mutation_p.L94F	NM_178834	NP_849156	Q6UX15	LAYN_HUMAN	layilin	246	Helical; (Potential).					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding				0		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		CCTTCTCCTCCTCCTTGTGGT	0.428													178	575					0	0	0	0	T	111428319	T	T	111428319	3	4	294	1	0	0	0	0	1	0	0	0	8689	681	24	4	734	4	LAYN	11	111428319	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3371054	111428319	23578197	223	54224											
HINFP	25988	broad.mit.edu	37	chr11	119001570	119001570	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgcaggccttgcaaagccAggctgaccttggcccctgca	7	7	12	15	0	0	1	0	1	0	0	0	1	0	1	5	3	4	5	5	3	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:119001570A>T	uc001pvp.2	+	4	506	c.317A>T	c.(316-318)CAG>CTG	p.Q106L	HINFP_uc010rzb.1_Missense_Mutation_p.Q106L|HINFP_uc001pvq.2_Missense_Mutation_p.Q106L|HINFP_uc001pvr.2_5'Flank	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	106					DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TTGCAAAGCCAGGCTGACCTT	0.567													37	114					0	0	0	0	T	119001570	T	T	119001570	3	4	294	1	0	0	0	0	1	0	0	0	7149	188	7	5	323	5	HINFP	11	119001570	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	7573251	119001570	16004946	224	54225											
ZNF202	7753	broad.mit.edu	37	chr11	123598283	123598283	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaacctgggagatctcatCaggtctggggattggaaatg	10	11	13	7	0	4	1	2	0	3	1	5	4	4	3	1	5	1	0	1	5	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:123598283C>A	uc001pzd.1	-	8	1253	c.853G>T	c.(853-855)GAT>TAT	p.D285Y	ZNF202_uc001pzc.1_Missense_Mutation_p.D61Y|ZNF202_uc001pze.1_Missense_Mutation_p.D285Y|ZNF202_uc001pzf.1_Missense_Mutation_p.D285Y	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	285	KRAB.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		GAGATCTCATCAGGTCTGGGG	0.473													11	54					6.31663e-08	7.22144e-08	1	0	A	123598283	A	A	123598283	3	1	294	1	0	0	0	0	1	0	0	0	17830	826	29	2	1101	2	ZNF202	11	123598283	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	4596713	123598283	11408233	225	54226											
TMEM225	338661	broad.mit.edu	37	chr11	123756006	123756006	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggactgtggttcatcttggCtctttcatcttctgaaatca	8	16	8	9	0	7	1	3	1	4	0	7	2	7	2	0	3	0	2	0	3	1	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:123756006C>T	uc001pzi.2	-	1	335	c.127G>A	c.(127-129)GCC>ACC	p.A43T		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	43						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						TTCATCTTGGCTCTTTCATCT	0.463													24	75					0	0	0	0	T	123756006	T	T	123756006	3	4	294	1	0	0	0	0	1	0	0	0	16213	797	28	4	566	4	TMEM225	11	123756006	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	157723	123756006	11250510	226	54227											
OR10G8	219869	broad.mit.edu	37	chr11	123900458	123900458	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgctggggaacctcctcatCctgctggtgatcagggtgga	6	10	15	10	0	2	1	2	1	0	0	4	3	4	3	3	5	3	2	3	5	1	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:123900458C>T	uc001pzp.1	+	1	129	c.129C>T	c.(127-129)ATC>ATT	p.I43I		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		ACCTCCTCATCCTGCTGGTGA	0.572													43	153					0	0	0	0	T	123900458	T	T	123900458	2	4	294	1	0	0	0	0	0	0	0	1	10957	845	30	2		2	OR10G8	11	123900458	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	144452	123900458	11106058	227	54228											
SIAE	54414	broad.mit.edu	37	chr11	124524633	124524633	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgaatgggagagacagagagGatgcggacagactgatatgc	14	6	16	5	1	0	5	0	2	0	3	0	10	0	8	0	3	2	0	0	3	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:124524633G>A	uc001qan.2	-	4	575	c.462C>T	c.(460-462)ATC>ATT	p.I154I		NM_170601	NP_733746	Q9HAT2	SIAE_HUMAN	sialate O-acetylesterase precursor	154						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		AGACAGAGAGGATGCGGACAG	0.483													33	123					0	0	0	0	A	124524633	A	A	124524633	2	1	294	1	0	0	0	0	0	0	0	1	14363	1164	41	2		2	SIAE	11	124524633	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	624175	124524633	10481883	228	54229											
OPCML	4978	broad.mit.edu	37	chr11	132307219	132307219	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcttgatgtcagagatctcCaggtactcatcctcacttac	9	12	7	13	1	4	2	3	1	1	1	6	3	5	2	2	1	2	2	2	1	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr11:132307219C>T	uc001qgs.2	-	4	611	c.561G>A	c.(559-561)CTG>CTA	p.L187L	OPCML_uc001qgu.2_Silent_p.L180L|OPCML_uc010sck.1_Silent_p.L187L|OPCML_uc001qgt.2_Silent_p.L186L|OPCML_uc010scl.1_Silent_p.L146L	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	187	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CAGAGATCTCCAGGTACTCAT	0.498													5	26					0	0	0	0	T	132307219	T	T	132307219	2	4	294	1	0	0	0	0	0	0	0	1	10928	581	21	4		4	OPCML	11	132307219	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	7782586	132307219	2699297	229	54230											
KCNA1	3736	broad.mit.edu	37	chr12	5020791	5020791	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaggaacgagtacttcttcGaccgcaaccggcccagcttc	9	8	10	14	4	1	1	0	1	1	0	3	4	1	2	3	2	4	3	3	2	3	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:5020791G>A	uc001qnh.2	+	2	1352	c.247G>A	c.(247-249)GAC>AAC	p.D83N		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	83					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GTACTTCTTCGACCGCAACCG	0.632													23	88					0	0	0	0	A	5020791	A	A	5020791	3	1	294	1	0	0	0	0	1	0	0	0	8040	1058	37	1	249	1	KCNA1	12	5020791	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08		5020791	128831104	230	54231											
ATN1	1822	broad.mit.edu	37	chr12	7045880	7045885	+	In_Frame_Del	DEL	CAGCAA	-	-																															caacacatcaccatcaccacCagcaacagcaacagcagcag																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:7045880_7045885delCAGCAA	uc001qrw.1	+	5	1687_1692	c.1450_1455delCAGCAA	c.(1450-1455)CAGCAAdel	p.QQ500del	ATN1_uc001qrx.1_In_Frame_Del_p.QQ500del|ATN1_uc001qry.1_In_Frame_Del_p.QQ485del	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	500_501	Poly-Gln.				cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCATCACCACcagcaacagcaacagc	0.447													---	---	---								-	7045885	-	-	7045880	7	5	294	1	0	1	0	1	0	0	0	0	1113	595	21	0	1464	0	ATN1	12	7045880	In_Frame_Del	DEL	CAGCAA	TCGA-DQ-7595-01A-11D-2229-08	2025089	7045880	126806015	231	54232											
GUCY2C	2984	broad.mit.edu	37	chr12	14772149	14772149	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagtctcccttcttacggagGccagtggattccatcctaga	8	11	9	13	1	2	1	0	0	2	1	5	3	4	3	4	3	1	0	4	3	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:14772149G>T	uc001rcd.2	-	24	3008	c.2871C>A	c.(2869-2871)GGC>GGA	p.G957G		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	957	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						TCTTACGGAGGCCAGTGGATT	0.463													25	66					3.1745e-13	4.0204e-13	1	0	T	14772149	T	T	14772149	2	4	294	1	0	0	0	0	0	0	0	1	6935	1190	42	4		4	GUCY2C	12	14772149	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	7726269	14772149	119079746	232	54233											
MGP	4256	broad.mit.edu	37	chr12	15035941	15035941	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gctctccatctctgctgaggGgatatgaaggtatttgcatt	8	14	11	8	0	2	2	0	2	2	0	4	3	2	3	1	3	2	4	1	3	3	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:15035941G>T	uc001rcn.1	-	3	238	c.135C>A	c.(133-135)TCC>TCA	p.S45S		NM_000900	NP_000891	P08493	MGP_HUMAN	matrix Gla protein precursor	45					cartilage condensation|cell differentiation|ossification|regulation of bone mineralization	proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent|structural constituent of bone			ovary(1)	1						TCTGCTGAGGGGATATGAAGG	0.393													24	67					1.13719e-10	1.38227e-10	1	0	T	15035941	T	T	15035941	2	4	294	1	0	0	0	0	0	0	0	1	9611	1219	43	4		4	MGP	12	15035941	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	263792	15035941	118815954	233	54234											
PIK3C2G	5288	broad.mit.edu	37	chr12	18793370	18793370	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttcctttgcagcatctccCagatggctctgcgcccagtg	5	13	9	14	1	2	1	0	0	2	1	4	1	3	1	3	1	3	3	3	1	0	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:18793370C>T	uc001rdt.2	+	31	4183	c.4067C>T	c.(4066-4068)CCA>CTA	p.P1356L	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.P1397L|PIK3C2G_uc010sic.1_Missense_Mutation_p.P1175L	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1356	C2.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				CAGCATCTCCCAGATGGCTCT	0.388													8	25					0	0	0	0	T	18793370	T	T	18793370	3	4	294	1	0	0	0	0	1	0	0	0	11966	594	21	4	4185	4	PIK3C2G	12	18793370	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3757429	18793370	115058525	234	54235											
KRT76	51350	broad.mit.edu	37	chr12	53171043	53171043	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaaccctggctcctgccActgaaggatttcttgcaaac	11	9	9	12	0	1	2	0	1	1	1	2	4	2	3	3	2	4	2	3	2	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:53171043A>G	uc001sax.2	-	1	87	c.33T>C	c.(31-33)AGT>AGC	p.S11S		NM_015848	NP_056932	Q01546	K22O_HUMAN	keratin 76	11	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|skin(1)	2						GGCTCCTGCCACTGAAGGATT	0.577													17	38					0	0	0	0	G	53171043	G	G	53171043	2	3	294	1	0	0	0	0	0	0	0	1	8528	156	6	5		5	KRT76	12	53171043	Silent	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	34377673	53171043	80680852	235	54236											
SILV	6490	broad.mit.edu	37	chr12	56348080	56348080	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggggtagacgcagccagtgaCtgctgctatgtggcaactgg	8	8	16	9	1	0	2	0	1	0	1	0	2	0	2	1	4	4	5	1	4	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:56348080C>T	uc001sip.2	-	11	1935	c.1904G>A	c.(1903-1905)AGT>AAT	p.S635N	SILV_uc001siq.2_Missense_Mutation_p.S642N|SILV_uc010spx.1_Missense_Mutation_p.S549N|SILV_uc001sir.2_Missense_Mutation_p.S635N	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	635	Cytoplasmic (Potential).				melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						CAGCCAGTGACTGCTGCTATG	0.527													11	65					0	0	0	0	T	56348080	T	T	56348080	3	4	294	1	0	0	0	0	1	0	0	0	14387	565	20	4	85	4	SILV	12	56348080	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3177037	56348080	77503815	236	54237											
SLC39A5	283375	broad.mit.edu	37	chr12	56625236	56625236	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgactgcagggggcttggcgCggcttctccacagcctgggg	4	8	17	12	2	1	1	0	1	1	0	2	1	1	1	2	6	2	3	2	6	0	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:56625236C>A	uc010sqj.1	+	4	435	c.178C>A	c.(178-180)CGG>AGG	p.R60R	SLC39A5_uc010sqi.1_Intron|SLC39A5_uc010sqk.1_Silent_p.R60R	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	60	Extracellular (By similarity).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2						GGGCTTGGCGCGGCTTCTCCA	0.652													36	79					3.33393e-15	4.40704e-15	1	0	A	56625236	A	A	56625236	2	1	294	1	0	0	0	0	0	0	0	1	14685	759	27	3		3	SLC39A5	12	56625236	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	277156	56625236	77226659	237	54238											
RDH16	8608	broad.mit.edu	37	chr12	57348845	57348845	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agagtcacatcaatcaccccCaacaagttcacgtccagtat	14	8	5	14	1	4	1	4	0	0	1	5	1	5	1	3	0	1	2	3	0	4	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:57348845C>T	uc001smi.3	-	2	589	c.417G>A	c.(415-417)TTG>TTA	p.L139L	RDH16_uc009zpa.2_Intron	NM_003708	NP_003699	O75452	RDH16_HUMAN	retinol dehydrogenase 16	139	Cytoplasmic (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity				0						CAATCACCCCCAACAAGTTCA	0.572													26	86					0	0	0	0	T	57348845	T	T	57348845	2	4	294	1	0	0	0	0	0	0	0	1	13259	593	21	4		4	RDH16	12	57348845	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	723609	57348845	76503050	238	54239											
PTPRR	5801	broad.mit.edu	37	chr12	71155305	71155305	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactttgatgcaaaacattGatattaagtgaacgaagaac	19	10	7	5	1	0	4	0	3	0	1	0	5	0	4	0	0	5	1	0	0	8	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:71155305G>T	uc001swi.1	-	4	989	c.573C>A	c.(571-573)ATC>ATA	p.I191I	PTPRR_uc010stq.1_Silent_p.I79I	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	191	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GCAAAACATTGATATTAAGTG	0.368													43	142					1.51926e-22	2.21602e-22	1	0	T	71155305	T	T	71155305	2	4	294	1	0	0	0	0	0	0	0	1	12875	1280	45	2		2	PTPRR	12	71155305	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	13806460	71155305	62696590	239	54240											
TRHDE	29953	broad.mit.edu	37	chr12	72893318	72893318	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgatgttctgcatgaagtgaTgctgctggacggtttggcca	7	12	14	8	2	1	2	0	2	1	0	1	4	1	3	1	3	3	5	1	3	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:72893318T>A	uc001sxa.2	+	6	1520	c.1490T>A	c.(1489-1491)ATG>AAG	p.M497K		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	497	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CATGAAGTGATGCTGCTGGAC	0.453													21	48					0	0	0	0	A	72893318	A	A	72893318	3	1	294	1	0	0	0	0	1	0	0	0	16546	1464	51	5	1512	5	TRHDE	12	72893318	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	1738013	72893318	60958577	240	54241											
EPYC	1833	broad.mit.edu	37	chr12	91358040	91358040	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtcctctagtgccttacGaatataagtcaaatttttaa	14	15	5	7	1	2	0	1	0	1	0	3	1	3	0	2	0	2	0	2	0	8	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:91358040G>T	uc001tbk.2	-	7	955	c.862C>A	c.(862-864)CGT>AGT	p.R288S		NM_004950	NP_004941	Q99645	EPYC_HUMAN	dermatan sulfate proteoglycan 3 precursor	288					female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			skin(1)	1						AGTGCCTTACGAATATAAGTC	0.363													26	70					5.61819e-17	7.59263e-17	1	0	T	91358040	T	T	91358040	3	4	294	1	0	0	0	0	1	0	0	0	5225	1058	37	3	110	3	EPYC	12	91358040	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	18464722	91358040	42493855	241	54242											
SLC17A8	246213	broad.mit.edu	37	chr12	100796512	100796512	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgaagaggtctttggatttGcaataagtaaggtaaacaca	15	12	10	4	0	1	2	0	1	1	1	1	3	1	3	0	3	2	3	0	3	6	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:100796512G>C	uc010svi.1	+	8	1355	c.1042G>C	c.(1042-1044)GCA>CCA	p.A348P	SLC17A8_uc009ztx.2_Intron	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	348	Vesicular (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						CTTTGGATTTGCAATAAGTAA	0.333													14	25					0	0	0	0	C	100796512	C	C	100796512	3	2	294	1	0	0	0	0	1	0	0	0	14488	1319	46	4	1072	4	SLC17A8	12	100796512	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	9438472	100796512	33055383	242	54243											
CORO1C	23603	broad.mit.edu	37	chr12	109042422	109042422	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttcttggggatgctgatcaGgtcgcacttcttgtttgcag	5	16	12	8	1	3	1	1	1	2	0	4	2	3	2	0	3	2	4	0	3	0	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:109042422G>A	uc001tnj.2	-	10	1360	c.1264C>T	c.(1264-1266)CTG>TTG	p.L422L	CORO1C_uc009zva.2_Silent_p.L475L|CORO1C_uc010sxf.1_Silent_p.L385L	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	422					actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						ATGCTGATCAGGTCGCACTTC	0.522													18	82					0	0	0	0	A	109042422	A	A	109042422	2	1	294	1	0	0	0	0	0	0	0	1	3770	991	35	4		4	CORO1C	12	109042422	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	8245910	109042422	24809473	243	54244											
USP30	84749	broad.mit.edu	37	chr12	109495876	109495876	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cagaaggagcccccctcacaCcagtatttatccttaacact	12	9	5	15	0	1	1	1	0	0	1	2	2	2	2	5	1	2	1	5	1	4	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:109495876C>G	uc010sxi.1	+	3	443	c.339C>G	c.(337-339)CAC>CAG	p.H113Q	USP30_uc001tnu.3_Missense_Mutation_p.H82Q	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	113	Cytoplasmic (Potential).				ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1						CCCCCTCACACCAGTATTTAT	0.483													77	382					0	0	0	0	G	109495876	G	G	109495876	3	3	294	1	0	0	0	0	1	0	0	0	17129	506	18	4	349	4	USP30	12	109495876	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	453454	109495876	24356019	244	54245											
OAS3	4940	broad.mit.edu	37	chr12	113384761	113384761	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accctgcagttgggcagttcTtgcagcggcagcttaagaga	9	9	13	10	1	1	1	0	0	1	1	1	2	1	1	1	2	4	7	1	2	1	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:113384761T>C	uc001tug.2	+	4	937	c.850T>C	c.(850-852)TTG>CTG	p.L284L		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	284	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						TGGGCAGTTCTTGCAGCGGCA	0.557													6	30					0	0	0	0	C	113384761	C	C	113384761	2	2	294	1	0	0	0	0	0	0	0	1	10855	1606	56	5		5	OAS3	12	113384761	Silent	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	3888885	113384761	20467134	245	54246											
DIABLO	56616	broad.mit.edu	37	chr12	122692938	122692938	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcaggccctcaatcctcaCgcaggtaggcctcctgctcc	6	8	9	18	1	3	0	3	0	0	0	6	0	6	0	5	3	1	4	5	3	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:122692938C>A	uc010tab.1	-	7	1515	c.710G>T	c.(709-711)CGT>CTT	p.R237L	DIABLO_uc010taa.1_Missense_Mutation_p.R184L|DIABLO_uc010tac.1_RNA|DIABLO_uc010tad.1_Missense_Mutation_p.R193L|VPS33A_uc001ucc.2_RNA	NM_019887	NP_063940	Q9NR28	DBLOH_HUMAN	diablo isoform 1 precursor	237					activation of caspase activity by cytochrome c|induction of apoptosis via death domain receptors	CD40 receptor complex|cytosol|internal side of plasma membrane|mitochondrial intermembrane space	protein binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000302)|Epithelial(86;0.00051)|BRCA - Breast invasive adenocarcinoma(302;0.223)		TCAATCCTCACGCAGGTAGGC	0.607													19	82					7.45023e-12	9.26896e-12	1	0	A	122692938	A	A	122692938	3	1	294	1	0	0	0	0	1	0	0	0	4539	536	19	3	13	3	DIABLO	12	122692938	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	9308177	122692938	11158957	246	54247											
GLT1D1	144423	broad.mit.edu	37	chr12	129442151	129442151	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgggaatgctgccgtggtgaAgcatgaagtcacagggctac	10	7	15	9	2	1	2	1	2	0	0	1	3	1	3	1	3	4	3	1	3	4	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:129442151A>G	uc010tbh.1	+	12	866	c.857A>G	c.(856-858)AAG>AGG	p.K286R	GLT1D1_uc001uhx.1_Missense_Mutation_p.K201R|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	281					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		GCCGTGGTGAAGCATGAAGTC	0.468													13	57					0	0	0	0	G	129442151	G	G	129442151	3	3	294	1	0	0	0	0	1	0	0	0	6502	72	3	5	628	5	GLT1D1	12	129442151	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	6749213	129442151	4409744	247	54248											
TMEM132D	121256	broad.mit.edu	37	chr12	129559166	129559166	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gtctgtcgtggtgccccgtcCctccatgagtcccatagaag	6	10	11	14	2	1	2	0	1	1	1	5	2	4	2	5	1	1	0	5	1	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:129559166C>A	uc009zyl.1	-	9	2882	c.2554G>T	c.(2554-2556)GGA>TGA	p.G852*	TMEM132D_uc001uia.2_Nonsense_Mutation_p.G390*	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	852	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GTGCCCCGTCCCTCCATGAGT	0.532													12	53					4.36969e-10	5.22141e-10	1	0	A	129559166	A	A	129559166	4	1	294	1	0	0	0	0	0	1	0	0	16113	632	22	4	749	4	TMEM132D	12	129559166	Nonsense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	117015	129559166	4292729	248	54249											
PIWIL1	9271	broad.mit.edu	37	chr12	130856065	130856065	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctccttgccagtacgcccaCaagctggcttttcttgttgg	5	13	10	13	1	1	0	0	0	1	0	2	0	2	0	3	2	3	5	3	2	2	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:130856065C>G	uc001uik.2	+	21	2598	c.2508C>G	c.(2506-2508)CAC>CAG	p.H836Q		NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	836	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		AGTACGCCCACAAGCTGGCTT	0.463													36	138					0	0	0	0	G	130856065	G	G	130856065	3	3	294	1	0	0	0	0	1	0	0	0	12012	477	17	4	2586	4	PIWIL1	12	130856065	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1296899	130856065	2995830	249	54250											
RIMBP2	23504	broad.mit.edu	37	chr12	130921644	130921644	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tccagaacttgctaatggctTtgattggggtgcaggtctcg	7	13	13	8	1	1	2	0	1	1	1	3	2	2	2	1	4	3	3	1	4	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:130921644T>C	uc001uil.2	-	10	1962	c.1798A>G	c.(1798-1800)AAG>GAG	p.K600E	RIMBP2_uc001uim.2_Missense_Mutation_p.K508E|RIMBP2_uc001uin.1_Missense_Mutation_p.K259E	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	600	Pro-rich.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GCTAATGGCTTTGATTGGGGT	0.657													6	9					0	0	0	0	C	130921644	C	C	130921644	3	2	294	1	0	0	0	0	1	0	0	0	13428	1850	64	5	1400	5	RIMBP2	12	130921644	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	65579	130921644	2930251	250	54251											
POLE	5426	broad.mit.edu	37	chr12	133253236	133253236	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gtcaaatgccaaaaccacagGgtcctgtggggacaaaataa	16	6	10	9	0	1	0	1	0	0	0	2	1	2	1	3	3	2	0	3	3	6	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr12:133253236G>A	uc001uks.1	-	9	849	c.805C>T	c.(805-807)CCT>TCT	p.P269S	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.P242S	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	269					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		AAAACCACAGGGTCCTGTGGG	0.498								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					9	17					0	0	0	0	A	133253236	A	A	133253236	3	1	294	1	0	0	0	0	1	0	0	0	12251	1232	43	4	6219	4	POLE	12	133253236	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2331592	133253236	598659	251	54252											
SACS	26278	broad.mit.edu	37	chr13	23907284	23907284	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacccaggatgtcataaaTgtaacatgatttttgggttt	11	15	8	7	0	1	1	1	1	0	0	2	2	2	2	2	2	1	2	2	2	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr13:23907284T>C	uc001uon.2	-	10	11320	c.10731A>G	c.(10729-10731)ACA>ACG	p.T3577T	SACS_uc001uoo.2_Silent_p.T3430T|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3577					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ATGTCATAAATGTAACATGAT	0.323													15	13					0	0	0	0	C	23907284	C	C	23907284	2	2	294	1	0	0	0	0	0	0	0	1	13869	1451	51	5		5	SACS	13	23907284	Silent	SNP	T	TCGA-DQ-7595-01A-11D-2229-08		23907284	91262594	252	54253											
CDK8	1024	broad.mit.edu	37	chr13	26911769	26911769	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatctctatgtcggcatgtaGagaaatagcagtaagtgaag	14	10	12	5	1	1	2	0	1	1	1	3	4	1	2	0	1	1	4	0	1	6	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr13:26911769G>A	uc001uqr.1	+	2	220	c.194G>A	c.(193-195)AGA>AAA	p.R65K	CDK8_uc001uqs.1_Missense_Mutation_p.R65K|CDK8_uc001uqt.1_5'UTR	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	65	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		TCGGCATGTAGAGAAATAGCA	0.284													28	55					0	0	0	0	A	26911769	A	A	26911769	3	1	294	1	0	0	0	0	1	0	0	0	3165	942	33	2	200	2	CDK8	13	26911769	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3004485	26911769	88258109	253	54254											
LCP1	3936	broad.mit.edu	37	chr13	46728938	46728938	+	Splice_Site	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggtaacggtgggaagacatAcctgaatggtgaaaggggtt	12	9	16	4	1	0	3	0	2	0	1	0	4	0	4	1	6	2	2	1	6	5	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr13:46728938A>T	uc001vaz.3	-	6	699	c.573_splice	c.e6+1	p.Q191_splice	LCP1_uc001vba.3_Splice_Site_p.Q191_splice	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin						regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		GGGAAGACATACCTGAATGGT	0.408			T	BCL6	NHL 								25	34					0	0	0	0	T	46728938	T	T	46728938	5	4	294	1	0	0	0	0	0	0	1	0	8731	405	14	5	1352	5	LCP1	13	46728938	Splice_Site	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	19817169	46728938	68440940	254	54255											
CAB39L	81617	broad.mit.edu	37	chr13	49925023	49925023	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctcagcataatcccacaacGtaaggcaatctgtggggctt	11	10	9	11	1	2	0	1	0	2	0	4	0	3	0	1	3	2	4	1	3	4	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr13:49925023G>T	uc001vcw.2	-	5	919	c.421C>A	c.(421-423)CGT>AGT	p.R141S	CAB39L_uc001vcx.2_Missense_Mutation_p.R141S|CAB39L_uc010adf.2_Missense_Mutation_p.R138S	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	141					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		ATCCCACAACGTAAGGCAATC	0.353													20	42					4.54149e-19	6.40349e-19	1	0	T	49925023	T	T	49925023	3	4	294	1	0	0	0	0	1	0	0	0	2538	1145	40	3	612	3	CAB39L	13	49925023	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3196085	49925023	65244855	255	54256											
MYCBP2	23077	broad.mit.edu	37	chr13	77835401	77835401	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagccatcgtgtccaactGagaagtgtactatctttgga	11	11	11	8	1	1	2	0	1	1	2	3	5	2	3	2	1	3	1	2	1	4	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr13:77835401G>A	uc001vkf.2	-	13	1734	c.1643C>T	c.(1642-1644)TCA>TTA	p.S548L	MYCBP2_uc010aev.2_5'UTR	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	548					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GTGTCCAACTGAGAAGTGTAC	0.428													30	68					0	0	0	0	A	77835401	A	A	77835401	3	1	294	1	0	0	0	0	1	0	0	0	10071	1294	45	2	12567	2	MYCBP2	13	77835401	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	27910378	77835401	37334477	256	54257											
SLITRK1	114798	broad.mit.edu	37	chr13	84454740	84454740	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccgtttggagcagacccTggtgtggcatgatcctcttg	5	12	12	12	1	1	2	0	1	1	1	3	3	3	3	4	3	1	3	4	3	0	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr13:84454740T>A	uc001vlk.2	-	1	1789	c.903A>T	c.(901-903)CCA>CCT	p.P301P		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	301	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GAGCAGACCCTGGTGTGGCAT	0.557													8	32					0	0	0	0	A	84454740	A	A	84454740	2	1	294	1	0	0	0	0	0	0	0	1	14806	1567	55	5		5	SLITRK1	13	84454740	Silent	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	6619339	84454740	30715138	257	54258											
F10	2159	broad.mit.edu	37	chr13	113793676	113793676	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atcctctctttgcagatggcGaccagtgtgagaccagtcct	8	11	10	12	1	1	2	0	1	1	2	4	4	3	2	4	1	1	1	4	1	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr13:113793676G>C	uc001vsx.2	+	4	319	c.262G>C	c.(262-264)GAC>CAC	p.D88H	F10_uc010agq.1_RNA|F10_uc001vsy.2_Missense_Mutation_p.D88H|F10_uc001vsz.2_Missense_Mutation_p.D88H	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	88	EGF-like 1; calcium-binding (Potential).				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCAGATGGCGACCAGTGTGA	0.507													13	22					0	0	0	0	C	113793676	C	C	113793676	3	2	294	1	0	0	0	0	1	0	0	0	5361	1058	37	3	276	3	F10	13	113793676	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	29338936	113793676	1376202	258	54259											
MYH6	4624	broad.mit.edu	37	chr14	23871681	23871681	+	Frame_Shift_Del	DEL	C	-	-																															tgcccctcccaccttcggtgCcgtctggctccgcctgctcc																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:23871681delC	uc001wjv.2	-	12	1200	c.1133delG	c.(1132-1134)GGCfs	p.G378fs	MYH6_uc010akp.1_Frame_Shift_Del_p.G378fs	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	378	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		ACCTTCGGTGCCGTCTGGCTC	0.627													---	---	---								-	23871681	-	-	23871681	7	5	294	1	0	1	0	1	0	0	0	0	10091	739	26	0	4798	0	MYH6	14	23871681	Frame_Shift_Del	DEL	C	TCGA-DQ-7595-01A-11D-2229-08		23871681	83477859	259	54260											
C14orf21	161424	broad.mit.edu	37	chr14	24769253	24769253	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaaggggtcggggcgcccCttaccaggccgtaagcggca	7	4	16	14	4	0	0	0	0	0	0	1	0	0	0	5	6	2	2	5	6	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:24769253C>G	uc001wol.1	+	1	156	c.93C>G	c.(91-93)CCC>CCG	p.P31P	DHRS1_uc001woj.1_5'Flank|DHRS1_uc001wok.2_5'Flank	NM_174913	NP_777573	Q86U38	CN021_HUMAN	hypothetical protein LOC161424	31							RNA binding			breast(2)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(265;0.0185)		CGGGGCGCCCCTTACCAGGCC	0.706													7	18					0	0	0	0	G	24769253	G	G	24769253	2	3	294	1	0	0	0	0	0	0	0	1	1775	668	24	4		4	C14orf21	14	24769253	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	897572	24769253	82580287	260	54261											
FSCB	84075	broad.mit.edu	37	chr14	44973723	44973723	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tacaacctgactacagttcaGgaggacgttgttttaattct	11	14	8	8	1	2	1	1	1	1	0	2	3	2	3	1	2	3	3	1	2	4	7			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:44973723G>T	uc001wvn.2	-	1	2777	c.2468C>A	c.(2467-2469)CCT>CAT	p.P823H		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	823						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CTACAGTTCAGGAGGACGTTG	0.393													10	47					1.08611e-07	1.22187e-07	1	0	T	44973723	T	T	44973723	3	4	294	1	0	0	0	0	1	0	0	0	6100	1000	35	4	13	4	FSCB	14	44973723	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	20204470	44973723	62375817	261	54262											
SAV1	60485	broad.mit.edu	37	chr14	51111689	51111689	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggtaaatcttcagaaccatgGttagtcaaatttcctaaaga	15	12	7	7	0	3	2	2	0	1	2	4	2	4	2	2	2	1	2	2	2	7	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:51111689G>A	uc001wyg.1	-	4	740	c.579C>T	c.(577-579)AAC>AAT	p.N193N	SAV1_uc001wyh.1_Silent_p.N193N	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	WW45 protein	193					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)	1	all_epithelial(31;0.000611)|Breast(41;0.0333)					CAGAACCATGGTTAGTCAAAT	0.378													12	47					0	0	0	0	A	51111689	A	A	51111689	2	1	294	1	0	0	0	0	0	0	0	1	13921	1252	44	4		4	SAV1	14	51111689	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	6137966	51111689	56237851	262	54263											
NID2	22795	broad.mit.edu	37	chr14	52520434	52520434	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgggggaacatccatttccGaaggcactggccctccatct	8	9	10	14	1	1	0	0	0	1	0	4	2	4	1	4	4	1	1	4	4	2	1	rs142884639	byFrequency	TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:52520434G>A	uc001wzo.2	-	5	1526	c.1292C>T	c.(1291-1293)TCG>TTG	p.S431L	NID2_uc010tqs.1_Missense_Mutation_p.S431L|NID2_uc010tqt.1_Missense_Mutation_p.S431L|NID2_uc001wzp.2_Missense_Mutation_p.S431L	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	431						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					ATCCATTTCCGAAGGCACTGG	0.537													20	78					0	0	0	0	A	52520434	A	A	52520434	3	1	294	1	0	0	0	0	1	0	0	0	10469	1059	37	1	2907	1	NID2	14	52520434	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1408745	52520434	54829106	263	54264											
SAMD4A	23034	broad.mit.edu	37	chr14	55241726	55241726	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgggcagacggaacccgcGccagtaccagatcccctctc	9	5	10	17	3	1	2	0	0	1	2	3	3	2	3	5	2	2	2	5	2	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:55241726G>T	uc001xbb.2	+	9	1788	c.1787G>T	c.(1786-1788)CGC>CTC	p.R596L	SAMD4A_uc001xbc.2_Missense_Mutation_p.R508L|SAMD4A_uc001xbg.2_Missense_Mutation_p.R188L	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	597					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						CGGAACCCGCGCCAGTACCAG	0.637													38	94					1.49673e-21	2.16821e-21	1	0	T	55241726	T	T	55241726	3	4	294	1	0	0	0	0	1	0	0	0	13886	1087	38	3	1821	3	SAMD4A	14	55241726	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2721292	55241726	52107814	264	54265											
KIAA0586	9786	broad.mit.edu	37	chr14	59014613	59014613	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgagtctcagcacaatgcAggaggacatggagtcttcgg	10	9	13	9	1	3	1	1	1	3	0	5	4	3	4	0	4	2	2	0	4	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:59014613A>T	uc001xdv.3	+	30	4655	c.4382A>T	c.(4381-4383)CAG>CTG	p.Q1461L	KIAA0586_uc010trr.1_Silent_p.A1606A|KIAA0586_uc001xdt.3_Missense_Mutation_p.Q1493L|KIAA0586_uc001xdu.3_Missense_Mutation_p.Q1522L|KIAA0586_uc010trs.1_Missense_Mutation_p.Q1452L	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	1461										ovary(1)	1						AGCACAATGCAGGAGGACATG	0.527													27	131					0	0	0	0	T	59014613	T	T	59014613	3	4	294	1	0	0	0	0	1	0	0	0	8225	188	7	5	4500	5	KIAA0586	14	59014613	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	3772887	59014613	48334927	265	54266											
KCNH5	27133	broad.mit.edu	37	chr14	63417206	63417206	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatattctaggtaatggtcCagtttcctagccacacggcc	9	11	8	13	1	1	0	0	0	1	0	3	0	3	0	5	3	1	2	5	3	4	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:63417206C>T	uc001xfx.2	-	7	1065	c.1014G>A	c.(1012-1014)CTG>CTA	p.L338L	KCNH5_uc001xfy.2_Silent_p.L338L|KCNH5_uc001xfz.1_Silent_p.L280L|KCNH5_uc001xga.2_Silent_p.L280L	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	338	Helical; Voltage-sensor; Name=Segment S4; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GGTAATGGTCCAGTTTCCTAG	0.473													23	58					0	0	0	0	T	63417206	T	T	63417206	2	4	294	1	0	0	0	0	0	0	0	1	8074	581	21	4		4	KCNH5	14	63417206	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	4402593	63417206	43932334	266	54267											
PLEKHG3	26030	broad.mit.edu	37	chr14	65207915	65207915	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggaccccccaggtgacatGgtggacttcgtggcagctga	8	8	14	11	1	0	2	0	2	0	0	1	4	0	4	3	5	1	2	3	5	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:65207915G>C	uc001xho.1	+	16	1949	c.1680G>C	c.(1678-1680)ATG>ATC	p.M560I	PLEKHG3_uc001xhn.1_Missense_Mutation_p.M504I|PLEKHG3_uc001xhp.2_Missense_Mutation_p.M681I|PLEKHG3_uc010aqh.1_Missense_Mutation_p.M102I|PLEKHG3_uc001xhq.1_Missense_Mutation_p.M65I	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	560					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CAGGTGACATGGTGGACTTCG	0.607													46	176					0	0	0	0	C	65207915	C	C	65207915	3	2	294	1	0	0	0	0	1	0	0	0	12125	1348	47	4	1562	4	PLEKHG3	14	65207915	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1790709	65207915	42141625	267	54268											
ZFYVE1	53349	broad.mit.edu	37	chr14	73490889	73490889	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtctccttttgttaccccCagaatgagtcctcttctggc	5	15	8	13	0	3	2	0	1	3	1	5	2	4	2	4	1	1	1	4	1	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:73490889C>A	uc001xnm.2	-	2	968	c.328G>T	c.(328-330)GGG>TGG	p.G110W	ZFYVE1_uc010arj.2_Missense_Mutation_p.G110W	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	110						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		TTGTTACCCCCAGAATGAGTC	0.493													71	245					3.82405e-32	5.79775e-32	1	0	A	73490889	A	A	73490889	3	1	294	1	0	0	0	0	1	0	0	0	17730	594	21	4	2049	4	ZFYVE1	14	73490889	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	8282974	73490889	33858651	268	54269											
KIAA1409	57578	broad.mit.edu	37	chr14	94084605	94084605	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacataacagtcaatacacTcaatgcgcagtatcatagct	15	10	5	11	1	4	0	4	0	0	0	4	0	4	0	0	0	4	3	0	0	6	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:94084605T>A	uc001ybv.1	+	27	3910	c.3827T>A	c.(3826-3828)CTC>CAC	p.L1276H	KIAA1409_uc001ybs.1_Missense_Mutation_p.L1254H	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1431						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GTCAATACACTCAATGCGCAG	0.428													21	75					0	0	0	0	A	94084605	A	A	94084605	3	1	294	1	0	0	0	0	1	0	0	0	8269	1551	54	5	3863	5	KIAA1409	14	94084605	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	20593716	94084605	13264935	269	54270											
DLK1	8788	broad.mit.edu	37	chr14	101200935	101200935	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagccggagcaccgcatccTgaaggtgtccatgaaagagc	11	5	13	12	2	0	3	0	2	0	1	2	4	2	4	4	2	3	3	4	2	2	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr14:101200935T>A	uc001yhs.3	+	5	1007	c.854T>A	c.(853-855)CTG>CAG	p.L285Q	DLK1_uc001yhu.3_Intron	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	285	Extracellular (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				CACCGCATCCTGAAGGTGTCC	0.657													27	85					0	0	0	0	A	101200935	A	A	101200935	3	1	294	1	0	0	0	0	1	0	0	0	4586	1580	55	5	872	5	DLK1	14	101200935	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	7116330	101200935	6148605	270	54271											
UBE3A	7337	broad.mit.edu	37	chr15	25616522	25616522	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacattgtgatacgtcaagtCacattccacgttaggtgaca	12	12	8	9	2	2	2	2	2	0	0	3	2	3	2	1	1	2	1	1	1	4	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:25616522C>A	uc001zaq.2	-	4	808	c.808G>T	c.(808-810)GAC>TAC	p.D270Y	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.D247Y|UBE3A_uc001zas.2_Missense_Mutation_p.D267Y|UBE3A_uc001zat.2_Missense_Mutation_p.D247Y	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	270					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		TACGTCAAGTCACATTCCACG	0.368													35	89					5.04308e-16	6.70825e-16	1	0	A	25616522	A	A	25616522	3	1	294	1	0	0	0	0	1	0	0	0	16947	826	29	2	1851	2	UBE3A	15	25616522	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08		25616522	76914870	271	54272											
PLCB2	5330	broad.mit.edu	37	chr15	40584575	40584575	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatgtagtccttcatctccAggaagatgaagagcgcaggc	11	9	12	9	1	2	3	1	1	1	2	4	4	3	4	2	2	1	3	2	2	4	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:40584575A>G	uc001zld.2	-	22	2697	c.2396T>C	c.(2395-2397)CTG>CCG	p.L799P	PLCB2_uc001zlc.2_5'Flank|PLCB2_uc010bbo.2_Missense_Mutation_p.L795P|PLCB2_uc010ucm.1_Missense_Mutation_p.L799P	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	799					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		CTTCATCTCCAGGAAGATGAA	0.597													19	55					0	0	0	0	G	40584575	G	G	40584575	3	3	294	1	0	0	0	0	1	0	0	0	12083	188	7	5	1205	5	PLCB2	15	40584575	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	14968053	40584575	61946817	272	54273											
GANC	2595	broad.mit.edu	37	chr15	42635316	42635316	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagtcacagaaccaaaagcCaccacagttgatgtgtttct	13	9	7	12	0	2	2	1	1	1	1	2	2	2	2	4	0	2	2	4	0	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:42635316C>T	uc001zpi.2	+	19	2507	c.2193C>T	c.(2191-2193)GCC>GCT	p.A731A		NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	731					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		AACCAAAAGCCACCACAGTTG	0.368													13	58					0	0	0	0	T	42635316	T	T	42635316	2	4	294	1	0	0	0	0	0	0	0	1	6269	581	21	4		4	GANC	15	42635316	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2050741	42635316	59896076	273	54274											
CGNL1	84952	broad.mit.edu	37	chr15	57816874	57816874	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaccgcagggagctcgcagaAatgcaaagacagttgaagga	16	4	13	8	2	0	3	0	1	0	2	1	5	0	5	1	2	3	5	1	2	4	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:57816874A>T	uc002aeg.2	+	12	3040	c.2964A>T	c.(2962-2964)GAA>GAT	p.E988D	CGNL1_uc010bfw.2_Missense_Mutation_p.E988D	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	988	Potential.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGCTCGCAGAAATGCAAAGAC	0.502													27	76					0	0	0	0	T	57816874	T	T	57816874	3	4	294	1	0	0	0	0	1	0	0	0	3319	11	1	5	3006	5	CGNL1	15	57816874	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	15181558	57816874	44714518	274	54275											
HERC1	8925	broad.mit.edu	37	chr15	63904629	63904629	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacctcacggtaccgcaccaCtttcttcaagacttccacag	10	9	5	17	2	3	1	2	0	1	1	4	1	4	1	4	1	1	2	4	1	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:63904629C>G	uc002amp.2	-	77	14369	c.14221G>C	c.(14221-14223)GTG>CTG	p.V4741L	HERC1_uc002amo.2_5'Flank	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4741	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TACCGCACCACTTTCTTCAAG	0.552													26	101					0	0	0	0	G	63904629	G	G	63904629	3	3	294	1	0	0	0	0	1	0	0	0	7096	565	20	4	372	4	HERC1	15	63904629	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	6087755	63904629	38626763	275	54276											
ITGA11	22801	broad.mit.edu	37	chr15	68606163	68606163	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tttgaggtggaagcgtaaggGggccacgttgtcttccttgg	6	12	16	7	2	1	1	0	1	1	0	2	2	2	2	2	5	1	2	2	5	2	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:68606163G>A	uc002ari.2	-	23	2923	c.2836C>T	c.(2836-2838)CCC>TCC	p.P946S	ITGA11_uc010bib.2_Missense_Mutation_p.P946S	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	946	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	AAGCGTAAGGGGGCCACGTTG	0.642													9	30					0	0	0	0	A	68606163	A	A	68606163	3	1	294	1	0	0	0	0	1	0	0	0	7913	1232	43	4	762	4	ITGA11	15	68606163	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	4701534	68606163	33925229	276	54277											
ARNT2	9915	broad.mit.edu	37	chr15	80762620	80762620	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgactcagtacatcacggagCtctccgacatggtccccaca	10	8	8	15	2	3	1	2	1	1	0	5	3	4	2	3	2	2	2	3	2	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:80762620C>A	uc002bfr.2	+	4	422	c.256C>A	c.(256-258)CTC>ATC	p.L86I	ARNT2_uc002bfq.2_Missense_Mutation_p.L86I|ARNT2_uc010unm.1_Missense_Mutation_p.L75I|ARNT2_uc002bfs.2_Missense_Mutation_p.L75I	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	86	Helix-loop-helix motif.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			CATCACGGAGCTCTCCGACAT	0.542													16	26					2.32078e-09	2.74984e-09	1	0	A	80762620	A	A	80762620	3	1	294	1	0	0	0	0	1	0	0	0	968	797	28	4	270	4	ARNT2	15	80762620	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	12156457	80762620	21768772	277	54278											
AKAP13	11214	broad.mit.edu	37	chr15	86118444	86118444	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttctgtgaggcatcatcgaGagttggacatctatacatta	11	13	10	7	1	3	2	1	1	2	1	4	4	3	3	0	2	1	3	0	2	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:86118444G>A	uc002blv.1	+	6	915	c.745G>A	c.(745-747)GAG>AAG	p.E249K	AKAP13_uc002blt.1_Missense_Mutation_p.E249K|AKAP13_uc002blu.1_Missense_Mutation_p.E249K	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	249					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GCATCATCGAGAGTTGGACAT	0.433													45	132					0	0	0	0	A	86118444	A	A	86118444	3	1	294	1	0	0	0	0	1	0	0	0	449	943	33	2	763	2	AKAP13	15	86118444	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	5355824	86118444	16412948	278	54279											
ACAN	176	broad.mit.edu	37	chr15	89398451	89398451	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagtggagatgtttcaggaCaccttgacttcagtgggcag	9	10	14	8	0	2	2	2	1	0	1	2	4	2	3	1	3	0	3	1	3	0	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:89398451C>A	uc010upo.1	+	12	3009	c.2635C>A	c.(2635-2637)CAC>AAC	p.H879N	ACAN_uc010upp.1_Missense_Mutation_p.H879N|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	879					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGTTTCAGGACACCTTGACTT	0.612													13	53					4.75885e-15	6.25153e-15	1	0	A	89398451	A	A	89398451	3	1	294	1	0	0	0	0	1	0	0	0	117	478	17	4	2677	4	ACAN	15	89398451	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3280007	89398451	13132941	279	54280											
CHD2	1106	broad.mit.edu	37	chr15	93528731	93528731	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcctcgatctttctcaggctCagacaaatgacagtgactct	10	11	8	12	1	4	3	2	2	3	1	6	4	4	3	1	1	0	1	1	1	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:93528731C>T	uc002bsp.2	+	26	3816	c.3241C>T	c.(3241-3243)CAG>TAG	p.Q1081*	CHD2_uc002bso.1_Nonsense_Mutation_p.Q1081*	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1081					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TTCTCAGGCTCAGACAAATGA	0.453													8	33					0	0	0	0	T	93528731	T	T	93528731	4	4	294	1	0	0	0	0	0	1	0	0	3340	827	29	2	3343	2	CHD2	15	93528731	Nonsense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	4130280	93528731	9002661	280	54281											
NR2F2	7026	broad.mit.edu	37	chr15	96877459	96877459	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acgtcgcgcttcggcagccaAtgcatgcagcccaacaacat	11	6	9	15	4	0	0	0	0	0	0	2	0	0	0	2	1	6	4	2	1	3	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr15:96877459A>T	uc010uri.1	+	2	1821	c.597A>T	c.(595-597)CAA>CAT	p.Q199H	NR2F2_uc002btp.2_Missense_Mutation_p.Q66H|NR2F2_uc010urj.1_Missense_Mutation_p.Q46H|NR2F2_uc010urk.1_Missense_Mutation_p.Q46H	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	199	Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			TCGGCAGCCAATGCATGCAGC	0.597													72	286					0	0	0	0	T	96877459	T	T	96877459	3	4	294	1	0	0	0	0	1	0	0	0	10682	98	4	5	650	5	NR2F2	15	96877459	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	3348728	96877459	5653933	281	54282											
PKD1	5310	broad.mit.edu	37	chr16	2158631	2158631	+	Frame_Shift_Del	DEL	G	-	-																															cggtactcagtctggtaggtGacgcagtcgcgcaggtcaac																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr16:2158631delG	uc002cos.1	-	15	6746	c.6537delC	c.(6535-6537)GTCfs	p.V2179fs	PKD1_uc002cot.1_Frame_Shift_Del_p.V2179fs	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2179	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TCTGGTAGGTGACGCAGTCGC	0.706													---	---	---								-	2158631	-	-	2158631	7	5	294	1	0	1	0	1	0	0	0	0	12018	1277	45	0	6502	0	PKD1	16	2158631	Frame_Shift_Del	DEL	G	TCGA-DQ-7595-01A-11D-2229-08		2158631	88196122	282	54283											
CASKIN1	57524	broad.mit.edu	37	chr16	2234977	2234977	+	Frame_Shift_Del	DEL	G	-	-																															gagccttccggaggcttggcGgggctgtcccccgggccgga																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr16:2234977delG	uc010bsg.1	-	13	1331	c.1299delC	c.(1297-1299)CCCfs	p.P433fs		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	433	CASK-binding (By similarity).				signal transduction	cytoplasm				skin(2)	2						GAGGCTTGGCGGGGCTGTCCC	0.667													---	---	---								-	2234977	-	-	2234977	7	5	294	1	0	1	0	1	0	0	0	0	2678	1103	39	0	3028	0	CASKIN1	16	2234977	Frame_Shift_Del	DEL	G	TCGA-DQ-7595-01A-11D-2229-08	76346	2234977	88119776	283	54284											
NLRC3	197358	broad.mit.edu	37	chr16	3614318	3614318	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctggctgggactgccaccGccaggctgggctccccgacg	4	5	14	18	3	0	0	0	0	0	0	1	2	1	1	6	4	1	3	6	4	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr16:3614318G>T	uc010btn.2	-	5	1031	c.620C>A	c.(619-621)GCG>GAG	p.A207E		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	207	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GACTGCCACCGCCAGGCTGGG	0.652													11	18					1.58986e-06	1.73328e-06	1	0	T	3614318	T	T	3614318	3	4	294	1	0	0	0	0	1	0	0	0	10522	1087	38	3	2642	3	NLRC3	16	3614318	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1379341	3614318	86740435	284	54285											
ADCY9	115	broad.mit.edu	37	chr16	4164621	4164621	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagctcccagtgcagggcccCggctccgggcgaggggaagc	6	3	17	15	3	0	0	0	0	0	0	2	2	2	1	4	5	3	3	4	5	1	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr16:4164621C>T	uc002cvx.2	-	2	1362	c.823G>A	c.(823-825)GGG>AGG	p.G275R		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	275	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						TGCAGGGCCCCGGCTCCGGGC	0.627													19	18					0	0	0	0	T	4164621	T	T	4164621	3	4	294	1	0	0	0	0	1	0	0	0	301	652	23	1	3278	1	ADCY9	16	4164621	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	550303	4164621	86190132	285	54286											
TMEM186	25880	broad.mit.edu	37	chr16	8890005	8890005	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	agtatgtgtcctgccgccagCcccagaagttcagatgggcc	8	8	12	13	1	1	2	1	0	0	2	2	2	2	2	6	1	2	2	6	1	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr16:8890005C>A	uc002cze.2	-	2	480	c.446G>T	c.(445-447)GGC>GTC	p.G149V	PMM2_uc002czf.3_5'Flank|PMM2_uc010uyf.1_5'Flank|PMM2_uc010uyg.1_5'Flank|PMM2_uc010uyh.1_5'Flank|PMM2_uc010buj.2_5'Flank|PMM2_uc010uyi.1_5'Flank|PMM2_uc010uye.1_5'Flank	NM_015421	NP_056236	Q96B77	TM186_HUMAN	transmembrane protein 186	149						integral to membrane|mitochondrion				ovary(1)	1						CTGCCGCCAGCCCCAGAAGTT	0.542													23	87					5.35356e-11	6.58301e-11	1	0	A	8890005	A	A	8890005	3	1	294	1	0	0	0	0	1	0	0	0	16174	739	26	4	199	4	TMEM186	16	8890005	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	4725384	8890005	81464748	286	54287											
CACNG3	10368	broad.mit.edu	37	chr16	24366278	24366278	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcattctcagcgcgggcatCttttttgtctctgcaggtga	5	15	11	10	2	4	1	2	1	3	0	6	1	4	1	0	2	2	2	0	2	0	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr16:24366278C>T	uc002dmf.2	+	3	1620	c.420C>T	c.(418-420)ATC>ATT	p.I140I		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	140	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		GCGCGGGCATCTTTTTTGTCT	0.577													10	42					0	0	0	0	T	24366278	T	T	24366278	2	4	294	1	0	0	0	0	0	0	0	1	2570	903	32	2		2	CACNG3	16	24366278	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	15476273	24366278	65988475	287	54288											
CDH5	1003	broad.mit.edu	37	chr16	66426224	66426224	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccagctgaaggaaaaccaGaagaagcctctgattggcac	14	7	10	10	0	1	4	0	2	1	2	2	5	2	5	3	2	3	2	3	2	5	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr16:66426224G>A	uc002eom.3	+	7	1311	c.1155G>A	c.(1153-1155)CAG>CAA	p.Q385Q	CDH5_uc002eon.1_Silent_p.Q385Q	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	385	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		AGGAAAACCAGAAGAAGCCTC	0.532													33	92					0	0	0	0	A	66426224	A	A	66426224	2	1	294	1	0	0	0	0	0	0	0	1	3128	933	33	2		2	CDH5	16	66426224	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	42059946	66426224	23928529	288	54289											
ZFHX3	463	broad.mit.edu	37	chr16	72991476	72991476	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtagagctcggcctcggCgggtgagggcaggctgccga	5	7	19	10	4	0	2	0	1	0	1	2	3	0	2	2	6	2	4	2	6	1	2	rs146607776		TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr16:72991476C>A	uc002fck.2	-	2	3242	c.2569G>T	c.(2569-2571)GCC>TCC	p.A857S	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	857					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TCGGCCTCGGCGGGTGAGGGC	0.577													26	58					8.24728e-16	1.09361e-15	1	0	A	72991476	A	A	72991476	3	1	294	1	0	0	0	0	1	0	0	0	17701	768	27	3	8578	3	ZFHX3	16	72991476	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	6565252	72991476	17363277	289	54290											
CNTNAP4	85445	broad.mit.edu	37	chr16	76532584	76532584	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggggcctctgctctgccaGggagacagtaagtggttaca	8	9	14	10	0	2	1	0	0	2	1	2	2	2	1	2	4	3	3	2	4	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr16:76532584G>T	uc002feu.1	+	17	2743	c.2358G>T	c.(2356-2358)CAG>CAT	p.Q786H	CNTNAP4_uc002fev.1_Missense_Mutation_p.Q650H|CNTNAP4_uc010chb.1_Missense_Mutation_p.Q713H|CNTNAP4_uc002fex.1_Missense_Mutation_p.Q789H	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	786	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TGCTCTGCCAGGGAGACAGTA	0.398													8	20					0.000673444	0.000696496	1	0	T	76532584	T	T	76532584	3	4	294	1	0	0	0	0	1	0	0	0	3664	991	35	4	2429	4	CNTNAP4	16	76532584	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3541108	76532584	13822169	290	54291											
TP53	7157	broad.mit.edu	37	chr17	7578262	7578262	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacgcaaatttccttccactCggataagatgctgaggaggg	11	9	11	10	2	0	2	0	1	0	1	3	4	2	4	2	3	1	2	2	3	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:7578262C>G	uc002gim.2	-	6	781	c.587G>C	c.(586-588)CGA>CCA	p.R196P	TP53_uc002gig.1_Missense_Mutation_p.R196P|TP53_uc002gih.2_Missense_Mutation_p.R196P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R64P|TP53_uc010cng.1_Missense_Mutation_p.R64P|TP53_uc002gii.1_Missense_Mutation_p.R64P|TP53_uc010cnh.1_Missense_Mutation_p.R196P|TP53_uc010cni.1_Missense_Mutation_p.R196P|TP53_uc002gij.2_Missense_Mutation_p.R196P|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.R103P|TP53_uc002gio.2_Missense_Mutation_p.R64P|TP53_uc010vug.1_Missense_Mutation_p.R157P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(123)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R196L(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCTTCCACTCGGATAAGATG	0.547		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	27					0	0	0	0	G	7578262	G	G	7578262	3	3	294	1	0	0	0	0	1	0	0	0	16448	884	31	3	707	3	TP53	17	7578262	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08		7578262	73616948	291	54292											
MYH8	4626	broad.mit.edu	37	chr17	10299732	10299732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccaattcatgaatttgctttCctccctctgcaatctgctca	8	15	4	14	0	4	1	2	1	2	0	6	1	6	1	3	0	3	3	3	0	3	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:10299732C>T	uc002gmm.2	-	33	4663	c.4568G>A	c.(4567-4569)GGA>GAA	p.G1523E	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1523	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						AATTTGCTTTCCTCCCTCTGC	0.428									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				7	16					0	0	0	0	T	10299732	T	T	10299732	3	4	294	1	0	0	0	0	1	0	0	0	10094	855	30	2	1277	2	MYH8	17	10299732	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2721470	10299732	70895478	292	54293											
HS3ST3A1	9955	broad.mit.edu	37	chr17	13399973	13399973	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggccgcttggacagcgtctgCgtgtagtccgagatggccct	5	9	15	12	4	1	1	0	0	1	1	2	3	2	2	3	3	2	2	3	3	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:13399973C>T	uc002gob.1	-	2	1560	c.762G>A	c.(760-762)ACG>ACA	p.T254T		NM_006042	NP_006033	Q9Y663	HS3SA_HUMAN	heparan sulfate D-glucosaminyl	254	PAPS and substrate.|Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			ovary(1)|central_nervous_system(1)	2		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ACAGCGTCTGCGTGTAGTCCG	0.647													13	76					0	0	0	0	T	13399973	T	T	13399973	2	4	294	1	0	0	0	0	0	0	0	1	7404	755	27	1		1	HS3ST3A1	17	13399973	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3100241	13399973	67795237	293	54294											
ZNHIT3	9326	broad.mit.edu	37	chr17	34848673	34848673	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcagaacagtgcaaccctgaAactcgtcctgttgagaaaaa	15	8	8	10	1	1	3	1	2	0	2	3	4	2	3	2	0	4	2	2	0	5	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:34848673A>C	uc002hms.1	+	3	206	c.135A>C	c.(133-135)GAA>GAC	p.E45D	ZNHIT3_uc010cus.1_Missense_Mutation_p.E45D|ZNHIT3_uc002hmt.1_RNA|ZNHIT3_uc010cut.1_RNA	NM_004773	NP_004764	Q15649	ZNHI3_HUMAN	thyroid hormone receptor interactor 3	45					regulation of transcription, DNA-dependent	intracellular	metal ion binding|thyroid hormone receptor binding				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0188)		GCAACCCTGAAACTCGTCCTG	0.448													22	87					0	0	0	0	C	34848673	C	C	34848673	3	2	294	1	0	0	0	0	1	0	0	0	18275	11	1	5	145	5	ZNHIT3	17	34848673	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	21448700	34848673	46346537	294	54295											
GH2	2689	broad.mit.edu	37	chr17	61958452	61958452	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gactctgagaagcagagggaGgtctgggggttctgcaggaa	10	7	18	6	0	3	2	0	1	3	2	3	6	3	4	0	5	2	3	0	5	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:61958452G>A	uc002jco.1	-	3	290	c.228C>T	c.(226-228)ACC>ACT	p.T76T	GH2_uc002jcj.2_Silent_p.T76T|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_Silent_p.T76T|GH2_uc002jcm.1_Silent_p.T76T|GH2_uc002jcn.1_Silent_p.T61T	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	76						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						AGCAGAGGGAGGTCTGGGGGT	0.532													74	277					0	0	0	0	A	61958452	A	A	61958452	2	1	294	1	0	0	0	0	0	0	0	1	6405	987	35	4		4	GH2	17	61958452	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	27109779	61958452	19236758	295	54296											
ABCA10	10349	broad.mit.edu	37	chr17	67150133	67150133	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgttgccttactgatgctctGctgccttgtaacaccacctg	6	14	8	13	0	1	1	0	1	1	0	1	1	1	1	4	0	6	4	4	0	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:67150133G>T	uc010dfa.1	-	33	4683	c.3804C>A	c.(3802-3804)AGC>AGA	p.S1268R	ABCA10_uc010wqs.1_Missense_Mutation_p.S260R|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1268	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CTGATGCTCTGCTGCCTTGTA	0.468													20	80					1.96895e-08	2.27559e-08	1	0	T	67150133	T	T	67150133	3	4	294	1	0	0	0	0	1	0	0	0	29	1310	46	4	859	4	ABCA10	17	67150133	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	5191681	67150133	14045077	296	54297											
C17orf77	146723	broad.mit.edu	37	chr17	72588882	72588882	+	Frame_Shift_Del	DEL	C	-	-																															ctgggctgtctgacccactgCcccttcccccaggaacactt																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:72588882delC	uc002jla.1	+	3	1059	c.697delC	c.(697-699)CCCfs	p.P233fs	CD300LD_uc002jkz.2_5'Flank	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	233						extracellular region					0						TGACCCACTGCCCCTTCCCCC	0.493													---	---	---								-	72588882	-	-	72588882	7	5	294	1	0	1	0	1	0	0	0	0	1890	739	26	0	699	0	C17orf77	17	72588882	Frame_Shift_Del	DEL	C	TCGA-DQ-7595-01A-11D-2229-08	5438749	72588882	8606328	297	54298											
USH1G	124590	broad.mit.edu	37	chr17	72916366	72916366	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcgccagatgctgcagccGgcggctcagggtgctggacg	6	5	17	13	4	1	1	1	0	0	1	1	2	1	2	2	4	5	4	2	4	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:72916366G>A	uc002jme.1	-	2	748	c.565C>T	c.(565-567)CGG>TGG	p.R189W	USH1G_uc010wro.1_Missense_Mutation_p.R86W	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	189					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					TGCTGCAGCCGGCGGCTCAGG	0.682													23	51					0	0	0	0	A	72916366	A	A	72916366	3	1	294	1	0	0	0	0	1	0	0	0	17103	1115	39	1	828	1	USH1G	17	72916366	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	327484	72916366	8278844	298	54299											
AFMID	125061	broad.mit.edu	37	chr17	76201735	76201735	+	Frame_Shift_Del	DEL	G	-	-																															aaggtggcccaggcacagccGgtggaccccacctgccgtgt																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:76201735delG	uc002jva.3	+	9	711	c.696delG	c.(694-696)CCGfs	p.P232fs	AFMID_uc002jvb.3_Intron|AFMID_uc002juz.3_Frame_Shift_Del_p.P232fs	NM_001010982	NP_001010982	Q63HM1	AFMID_HUMAN	arylformamidase isoform 1	232						cytosol|nucleus	arylformamidase activity			large_intestine(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			AGGCACAGCCGGTGGACCCCA	0.652													---	---	---								-	76201735	-	-	76201735	7	5	294	1	0	1	0	1	0	0	0	0	362	1103	39	0	730	0	AFMID	17	76201735	Frame_Shift_Del	DEL	G	TCGA-DQ-7595-01A-11D-2229-08	3285369	76201735	4993475	299	54300											
RPTOR	57521	broad.mit.edu	37	chr17	78899188	78899188	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agactgcggacgacgcggacGatgctgctggacacaaaagt	12	5	14	10	5	0	1	0	0	0	1	0	6	0	4	0	3	3	2	0	3	2	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:78899188G>T	uc002jyt.1	+	24	3632	c.2827G>T	c.(2827-2829)GAT>TAT	p.D943Y	RPTOR_uc010wug.1_Missense_Mutation_p.D785Y	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	943					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CGACGCGGACGATGCTGCTGG	0.577													20	55					1.40151e-16	1.88203e-16	1	0	T	78899188	T	T	78899188	3	4	294	1	0	0	0	0	1	0	0	0	13730	1058	37	3	2921	3	RPTOR	17	78899188	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2697453	78899188	2296022	300	54301											
CD7	924	broad.mit.edu	37	chr17	80274611	80274611	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tggcctggcaggtgtaggtgCcagtgtccgacagctgcagg	6	8	17	10	1	0	0	0	0	0	0	1	1	1	0	3	5	3	4	3	5	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr17:80274611C>A	uc002kel.1	-	2	438	c.329G>T	c.(328-330)GGC>GTC	p.G110V	CD7_uc010din.2_Missense_Mutation_p.G110V|CD7_uc002kem.2_Missense_Mutation_p.W91C|CD7_uc010wvk.1_Missense_Mutation_p.G110V	NM_006137	NP_006128	P09564	CD7_HUMAN	CD7 antigen precursor	110	Ig-like.|Extracellular (Probable).				immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)			GGTGTAGGTGCCAGTGTCCGA	0.637													69	290					2.51111e-31	3.78006e-31	1	0	A	80274611	A	A	80274611	3	1	294	1	0	0	0	0	1	0	0	0	3047	739	26	4	405	4	CD7	17	80274611	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1375423	80274611	920599	301	54302											
RBBP8	5932	broad.mit.edu	37	chr18	20572878	20572878	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaacatctgaaaacactccCttttagcaacacttgtatat	16	12	3	10	0	1	1	0	1	1	0	2	1	2	1	1	0	4	2	1	0	8	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr18:20572878C>T	uc002ktw.2	+	11	1419	c.1088C>T	c.(1087-1089)CCT>CTT	p.P363L	RBBP8_uc002kty.2_Missense_Mutation_p.P363L|RBBP8_uc002ktz.2_Missense_Mutation_p.P363L|RBBP8_uc002kua.2_Missense_Mutation_p.P363L|RBBP8_uc002ktx.1_Missense_Mutation_p.P363L	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	363					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			AAAACACTCCCTTTTAGCAAC	0.363								Direct_reversal_of_damage|Homologous_recombination					29	70					0	0	0	0	T	20572878	T	T	20572878	3	4	294	1	0	0	0	0	1	0	0	0	13170	681	24	4	1126	4	RBBP8	18	20572878	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08		20572878	57504370	302	54303											
TAF4B	6875	broad.mit.edu	37	chr18	23866365	23866365	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctgggaccacatctgacaagCctgttattgggactccagtt	9	11	10	11	0	1	1	0	1	1	0	2	3	2	3	3	2	1	2	3	2	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr18:23866365C>G	uc002kvu.3	+	7	1981	c.1492C>G	c.(1492-1494)CCT>GCT	p.P498A	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.P498A	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	498					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			ATCTGACAAGCCTGTTATTGG	0.488													19	76					0	0	0	0	G	23866365	G	G	23866365	3	3	294	1	0	0	0	0	1	0	0	0	15593	739	26	4	1518	4	TAF4B	18	23866365	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	3293487	23866365	54210883	303	54304											
SLC39A6	25800	broad.mit.edu	37	chr18	33706800	33706800	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tagcggtagaaaagctgttgTagatgatattgccgtgtgga	11	12	14	4	2	0	3	0	1	0	2	0	4	0	4	1	2	3	4	1	2	6	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr18:33706800T>C	uc010dmy.2	-	2	461	c.171A>G	c.(169-171)CTA>CTG	p.L57L	SLC39A6_uc002kzj.2_Intron	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	57	Extracellular (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						AAAGCTGTTGTAGATGATATT	0.373													34	66					0	0	0	0	C	33706800	C	C	33706800	2	2	294	1	0	0	0	0	0	0	0	1	14686	1625	57	5		5	SLC39A6	18	33706800	Silent	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	9840435	33706800	44370448	304	54305											
ELP2	55250	broad.mit.edu	37	chr18	33750057	33750057	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgagtgcgactccactgAtgactgtattgagcacaaca	11	9	12	9	1	0	4	0	4	0	0	1	5	1	4	1	1	3	2	1	1	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr18:33750057A>G	uc002kzk.1	+	20	2118	c.2108A>G	c.(2107-2109)GAT>GGT	p.D703G	ELP2_uc010xcg.1_Missense_Mutation_p.D768G|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Missense_Mutation_p.D677G|ELP2_uc010xch.1_Missense_Mutation_p.D698G|ELP2_uc002kzn.1_Missense_Mutation_p.D633G|ELP2_uc002kzo.1_Missense_Mutation_p.D633G	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	703	WD 12.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						GACTCCACTGATGACTGTATT	0.527													19	39					0	0	0	0	G	33750057	G	G	33750057	3	3	294	1	0	0	0	0	1	0	0	0	5104	333	12	5	2186	5	ELP2	18	33750057	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	43257	33750057	44327191	305	54306											
DCC	1630	broad.mit.edu	37	chr18	50985774	50985774	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgccaagacctcacaccaGtcagccacagccagtcagaa	13	5	8	15	0	3	2	3	0	0	2	3	2	3	2	5	0	3	1	5	0	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr18:50985774G>C	uc002lfe.1	+	24	4152	c.3565G>C	c.(3565-3567)GTC>CTC	p.V1189L	DCC_uc010dpf.1_Missense_Mutation_p.V824L	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1189	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCTCACACCAGTCAGCCACAG	0.458													59	88					0	0	0	0	C	50985774	C	C	50985774	3	2	294	1	0	0	0	0	1	0	0	0	4299	1029	36	4	3659	4	DCC	18	50985774	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	17235717	50985774	27091474	306	54307											
WDR7	23335	broad.mit.edu	37	chr18	54424273	54424273	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggggtttgaatgaagtactgGatgaagtttgcctggatcgc	9	12	15	5	1	0	3	0	3	0	0	1	5	0	5	1	4	2	3	1	4	4	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr18:54424273G>T	uc002lgk.1	+	15	2660	c.2449G>T	c.(2449-2451)GAT>TAT	p.D817Y	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.D817Y	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	817										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TGAAGTACTGGATGAAGTTTG	0.473													72	119					1.14856e-27	1.71071e-27	1	0	T	54424273	T	T	54424273	3	4	294	1	0	0	0	0	1	0	0	0	17388	1174	41	2	2503	2	WDR7	18	54424273	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3438499	54424273	23652975	307	54308											
ATP9B	374868	broad.mit.edu	37	chr18	77107889	77107889	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcggcggcactcggccagttCgtcatgcacaggggccttat	6	9	13	13	4	1	0	1	0	0	0	4	0	1	0	2	5	1	3	2	5	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr18:77107889C>T	uc002lmx.2	+	24	2816	c.2802C>T	c.(2800-2802)TTC>TTT	p.F934F	ATP9B_uc002lmw.1_Silent_p.F934F|ATP9B_uc002lmz.1_Silent_p.F628F|ATP9B_uc002lna.2_5'UTR|ATP9B_uc002lnb.1_Silent_p.F54F|ATP9B_uc010drb.2_RNA	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	934	Helical; (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		TCGGCCAGTTCGTCATGCACA	0.627													25	60					0	0	0	0	T	77107889	T	T	77107889	2	4	294	1	0	0	0	0	0	0	0	1	1201	883	31	1		1	ATP9B	18	77107889	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	22683616	77107889	969359	308	54309											
RNF126	55658	broad.mit.edu	37	chr19	651671	651671	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgcgtggtgaggcgggcgCggggctgtcgggcgccgtac	2	5	22	12	8	0	1	0	1	0	0	1	1	0	1	2	6	1	2	2	6	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:651671C>A	uc010drs.2	-	4	489	c.383G>T	c.(382-384)CGC>CTC	p.R128L	RNF126_uc002lpi.2_5'UTR	NM_194460	NP_919442	Q9BV68	RN126_HUMAN	ring finger protein 126	128							protein binding|zinc ion binding				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGCGGGCGCGGGGCTGTCG	0.781													5	4					0.000602214	0.000624355	1	0	A	651671	A	A	651671	3	1	294	1	0	0	0	0	1	0	0	0	13500	768	27	3	576	3	RNF126	19	651671	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08		651671	58477312	309	54310											
PCSK4	54760	broad.mit.edu	37	chr19	1484088	1484088	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgaggccgaggtgcccgtGtgctggtctgtgcacccgtg	3	9	17	12	3	1	1	0	1	1	0	1	2	1	1	3	3	3	3	3	3	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:1484088G>A	uc002ltb.1	-	9	1169	c.1107C>T	c.(1105-1107)CAC>CAT	p.H369H	PCSK4_uc002lsz.2_5'Flank|PCSK4_uc002lta.2_Silent_p.H181H	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	369	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTGCCCGTGTGCTGGTCTG	0.697													6	4					0	0	0	0	A	1484088	A	A	1484088	2	1	294	1	0	0	0	0	0	0	0	1	11656	1368	48	4		4	PCSK4	19	1484088	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	832417	1484088	57644895	310	54311											
PLIN5	440503	broad.mit.edu	37	chr19	4523641	4523642	+	In_Frame_Ins	INS	-	CCCATT	CCCATT																															acacccatcctgtccccatcINScccattcccactcccgtccc																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:4523641_4523642insCCCATT	uc002mas.2	-	8	1343_1344	c.1290_1291insAATGGG	c.(1288-1293)insAATGGG	p.430_431insNG		NM_001013706	NP_001013728	Q00G26	PLIN5_HUMAN	lipid storage droplet protein 5	430_431						lipid particle					0						CTGTCCCCATCCCCATTCCCAC	0.688											OREG0025168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								CCCATT	4523642	CCCATT	CCCATT	4523641	7	5	294	1	0	1	1	0	0	0	0	0	12148	855	30	0	104	0	PLIN5	19	4523641	In_Frame_Ins	INS	-	TCGA-DQ-7595-01A-11D-2229-08	3039553	4523641	54605342	311	54312											
FBN3	84467	broad.mit.edu	37	chr19	8168502	8168502	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctgcagggcagacacaggtgTagttccccagggtgttgtag	8	9	15	9	0	0	1	0	0	0	1	1	1	1	1	2	3	1	6	2	3	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:8168502T>C	uc002mjf.2	-	38	4904	c.4883A>G	c.(4882-4884)TAC>TGC	p.Y1628C		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1628	EGF-like 25; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GACACAGGTGTAGTTCCCCAG	0.557													26	57					0	0	0	0	C	8168502	C	C	8168502	3	2	294	1	0	0	0	0	1	0	0	0	5736	1638	57	5	3650	5	FBN3	19	8168502	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	3644861	8168502	50960481	312	54313											
MUC16	94025	broad.mit.edu	37	chr19	8971730	8971730	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcccagccaatggaatgaggCattcagggtcttatctagaa	12	9	11	9	0	3	2	1	1	2	1	3	3	3	3	2	3	1	1	2	3	5	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:8971730C>A	uc002mkp.2	-	78	43066	c.42862G>T	c.(42862-42864)GCC>TCC	p.A14288S	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.A1088S|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGAATGAGGCATTCAGGGTC	0.532													20	51					1.64113e-05	1.76641e-05	1	0	A	8971730	A	A	8971730	3	1	294	1	0	0	0	0	1	0	0	0	10026	710	25	4	689	4	MUC16	19	8971730	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	803228	8971730	50157253	313	54314											
MUC16	94025	broad.mit.edu	37	chr19	9014654	9014654	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagggcttttggggtcaagaCggtgggtgcagatggcatcc	7	9	17	8	1	1	2	1	0	0	2	2	2	2	2	1	6	1	3	1	6	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:9014654C>T	uc002mkp.2	-	31	38525	c.38321G>A	c.(38320-38322)CGT>CAT	p.R12774H	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12776	SEA 5.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGGTCAAGACGGTGGGTGCA	0.567													9	48					0	0	0	0	T	9014654	T	T	9014654	3	4	294	1	0	0	0	0	1	0	0	0	10026	536	19	1	5418	1	MUC16	19	9014654	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	42924	9014654	50114329	314	54315											
MUC16	94025	broad.mit.edu	37	chr19	9020781	9020781	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacctgagagaggtcagtcTgcagccagagtacagagggc	11	6	14	10	0	3	4	2	1	1	3	3	5	3	4	2	2	3	2	2	2	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:9020781T>G	uc002mkp.2	-	20	37525	c.37321A>C	c.(37321-37323)AGA>CGA	p.R12441R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12443	Extracellular (Potential).|SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGGTCAGTCTGCAGCCAGAG	0.537													43	163					0	0	0	0	G	9020781	G	G	9020781	2	3	294	1	0	0	0	0	0	0	0	1	10026	1588	55	5		5	MUC16	19	9020781	Silent	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	6127	9020781	50108202	315	54316											
MUC16	94025	broad.mit.edu	37	chr19	9048036	9048036	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgtacagtaggggagacagCtaaagttggaatggctgaaa	14	9	14	4	0	0	2	0	1	0	1	0	4	0	3	0	4	2	5	0	4	6	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:9048036C>T	uc002mkp.2	-	5	33799	c.33595G>A	c.(33595-33597)GCT>ACT	p.A11199T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11201	Thr-rich.|Extracellular (Potential).			A -> G (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGGAGACAGCTAAAGTTGGA	0.453													6	34					0	0	0	0	T	9048036	T	T	9048036	3	4	294	1	0	0	0	0	1	0	0	0	10026	797	28	4	10248	4	MUC16	19	9048036	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	27255	9048036	50080947	316	54317											
MUC16	94025	broad.mit.edu	37	chr19	9088992	9088992	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attgttgccgtcccagtgagGtgagatattttaggaagagc	10	12	13	6	1	0	3	0	2	0	2	1	5	1	4	2	2	2	1	2	2	3	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:9088992G>A	uc002mkp.2	-	1	3027	c.2823C>T	c.(2821-2823)CAC>CAT	p.H941H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	941	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCCAGTGAGGTGAGATATTT	0.483													33	76					0	0	0	0	A	9088992	A	A	9088992	2	1	294	1	0	0	0	0	0	0	0	1	10026	1252	44	4		4	MUC16	19	9088992	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	40956	9088992	50039991	317	54318											
OLFM2	93145	broad.mit.edu	37	chr19	9964938	9964938	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtggccgttgttccaggtaTagagggcgcgctcccggggg	4	8	19	10	4	0	1	0	0	0	1	2	1	2	1	3	6	0	4	3	6	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:9964938T>C	uc002mmp.2	-	6	1317	c.1289A>G	c.(1288-1290)TAT>TGT	p.Y430C	OLFM2_uc002mmo.2_Missense_Mutation_p.Y352C	NM_058164	NP_477512	O95897	NOE2_HUMAN	olfactomedin 2 precursor	430	Olfactomedin-like.					extracellular region				large_intestine(1)|skin(1)	2						GTTCCAGGTATAGAGGGCGCG	0.572													30	99					0	0	0	0	C	9964938	C	C	9964938	3	2	294	1	0	0	0	0	1	0	0	0	10907	1406	49	5	79	5	OLFM2	19	9964938	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	875946	9964938	49164045	318	54319											
EPS15L1	58513	broad.mit.edu	37	chr19	16504767	16504767	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacactgaattttacctgttGaagttgtctgctgttctgca	9	16	8	8	0	2	2	0	2	2	0	2	2	2	2	1	0	4	5	1	0	4	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:16504767G>C	uc002ndz.1	-	18	1967	c.1961C>G	c.(1960-1962)TCA>TGA	p.S654*	EPS15L1_uc002ndx.2_Nonsense_Mutation_p.S654*|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Nonsense_Mutation_p.S544*|EPS15L1_uc010xpf.1_Nonsense_Mutation_p.S557*|EPS15L1_uc002nea.1_Nonsense_Mutation_p.S654*|EPS15L1_uc010eah.1_Nonsense_Mutation_p.S656*	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	654	15 X 3 AA repeats of D-P-F.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						TTTACCTGTTGAAGTTGTCTG	0.537													35	79					0	0	0	0	C	16504767	C	C	16504767	4	2	294	1	0	0	0	0	0	1	0	0	5217	1294	45	2	657	2	EPS15L1	19	16504767	Nonsense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	6539829	16504767	42624216	319	54320											
NCAN	1463	broad.mit.edu	37	chr19	19349079	19349079	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cagacaccgagggctgtgacCgcggctggcataagttccag	9	6	14	12	3	0	2	0	1	0	1	1	3	1	2	3	3	0	4	3	3	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:19349079C>A	uc002nlz.2	+	11	3367	c.3268C>A	c.(3268-3270)CGC>AGC	p.R1090S	NCAN_uc010ecc.1_Missense_Mutation_p.R654S|NCAN_uc002nma.2_5'Flank	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1090	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GGGCTGTGACCGCGGCTGGCA	0.657													26	151					1.17739e-12	1.48225e-12	1	0	A	19349079	A	A	19349079	3	1	294	1	0	0	0	0	1	0	0	0	10258	652	23	3	3306	3	NCAN	19	19349079	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2844312	19349079	39779904	320	54321											
ZNF536	9745	broad.mit.edu	37	chr19	30935513	30935513	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaacgagttccgctgcgaGgtgtgcggtcaggtgttcag	6	9	16	10	4	2	0	2	0	0	0	3	2	3	0	2	3	3	3	2	3	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:30935513G>C	uc002nsu.1	+	2	1182	c.1044G>C	c.(1042-1044)GAG>GAC	p.E348D	ZNF536_uc010edd.1_Missense_Mutation_p.E348D	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	348	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TCCGCTGCGAGGTGTGCGGTC	0.652													49	223					0	0	0	0	C	30935513	C	C	30935513	3	2	294	1	0	0	0	0	1	0	0	0	18041	991	35	4	1046	4	ZNF536	19	30935513	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	11586434	30935513	28193470	321	54322											
TSHZ3	57616	broad.mit.edu	37	chr19	31767842	31767842	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcgaagctggtatttcaCgttggccagccagtggctga	7	11	12	11	2	1	1	1	1	0	0	2	2	1	1	3	3	2	4	3	3	2	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:31767842C>A	uc002nsy.3	-	2	2922	c.2857G>T	c.(2857-2859)GTG>TTG	p.V953L		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	953	Homeobox; atypical.			VKY->ATA: Does not inhibit interaction with APBB1.	negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TGGTATTTCACGTTGGCCAGC	0.532													22	48					4.7796e-09	5.60048e-09	1	0	A	31767842	A	A	31767842	3	1	294	1	0	0	0	0	1	0	0	0	16692	536	19	3	392	3	TSHZ3	19	31767842	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	832329	31767842	27361141	322	54323											
ZNF420	147923	broad.mit.edu	37	chr19	37619744	37619744	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggtgagaagccctatgaatgCagagaatgtagaaaggcctt	14	8	13	6	0	0	4	0	2	0	3	0	6	0	4	2	2	2	2	2	2	6	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:37619744C>T	uc002ofl.2	+	5	2066	c.1851C>T	c.(1849-1851)TGC>TGT	p.C617C		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	617	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCTATGAATGCAGAGAATGTA	0.433													11	41					0	0	0	0	T	37619744	T	T	37619744	2	4	294	1	0	0	0	0	0	0	0	1	17964	718	25	4		4	ZNF420	19	37619744	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	5851902	37619744	21509239	323	54324											
ZNF585B	92285	broad.mit.edu	37	chr19	37676952	37676953	+	Frame_Shift_Ins	INS	-	AT	AT																															ggcctttccacatttggaacINSatatataagatttctctcct																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:37676952_37676953insAT	uc002ofq.2	-	5	1740_1741	c.1486_1487insAT	c.(1486-1488)TGTfs	p.C496fs	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Frame_Shift_Ins_p.C310fs	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	496	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACATTTGGAACATATATAAGAT	0.401													---	---	---								AT	37676953	AT	AT	37676952	7	5	294	1	0	1	1	0	0	0	0	0	18085	478	17	0	826	0	ZNF585B	19	37676952	Frame_Shift_Ins	INS	-	TCGA-DQ-7595-01A-11D-2229-08	57208	37676952	21452031	324	54325											
ZNF780B	163131	broad.mit.edu	37	chr19	40540472	40540472	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gaggttgaacaaggtttgagCcacgattaaaggccttccca	12	9	11	9	1	0	2	0	2	0	0	1	4	1	2	3	3	2	2	3	3	4	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:40540472C>A	uc002omu.2	-	5	2359	c.2294G>T	c.(2293-2295)GGC>GTC	p.G765V	ZNF780B_uc002omv.2_Missense_Mutation_p.G617V	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	765	C2H2-type 22; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AAGGTTTGAGCCACGATTAAA	0.433													31	67					9.45814e-24	1.394e-23	1	0	A	40540472	A	A	40540472	3	1	294	1	0	0	0	0	1	0	0	0	18220	739	26	4	211	4	ZNF780B	19	40540472	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	2863520	40540472	18588511	325	54326											
PSG8	440533	broad.mit.edu	37	chr19	43268377	43268377	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcagaaactttggttggctGggcttcaatcgtgacttggg	7	13	13	8	1	2	2	2	1	0	1	3	2	2	2	0	4	1	3	0	4	2	4	rs150588080	byFrequency	TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:43268377G>T	uc002ouo.2	-	2	219	c.121C>A	c.(121-123)CAG>AAG	p.Q41K	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Missense_Mutation_p.Q41K|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_5'UTR|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Missense_Mutation_p.Q41K|PSG8_uc002oum.3_Missense_Mutation_p.Q41K|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.Q41K	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	41	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				TTGGTTGGCTGGGCTTCAATC	0.468													51	203					2.73381e-35	4.15971e-35	1	0	T	43268377	T	T	43268377	3	4	294	1	0	0	0	0	1	0	0	0	12723	1357	47	4	1196	4	PSG8	19	43268377	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2727905	43268377	15860606	326	54327											
SIX5	147912	broad.mit.edu	37	chr19	46271390	46271390	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cctgcgtgagcgacaggccgGtgagtgtggccaggcggcgc	5	5	19	12	5	0	2	0	2	0	0	0	3	0	2	3	5	2	0	3	5	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:46271390G>A	uc002pdb.2	-	1	1108	c.713C>T	c.(712-714)ACC>ATC	p.T238I	SIX5_uc002pdc.2_Missense_Mutation_p.T238I	NM_175875	NP_787071	Q8N196	SIX5_HUMAN	SIX homeobox 5	238	Homeobox.					cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00783)|GBM - Glioblastoma multiforme(486;0.0802)|Epithelial(262;0.235)		CGACAGGCCGGTGAGTGTGGC	0.711													9	25					0	0	0	0	A	46271390	A	A	46271390	3	1	294	1	0	0	0	0	1	0	0	0	14415	1261	44	4	1518	4	SIX5	19	46271390	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3003013	46271390	12857593	327	54328											
NOVA2	4858	broad.mit.edu	37	chr19	46444058	46444058	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcgggctcgccgctgaccGtcaccacgcgctcctgcagg	4	6	13	18	6	1	1	1	1	0	0	4	1	2	1	4	2	1	5	4	2	0	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:46444058G>A	uc002pdv.2	-	4	590	c.542C>T	c.(541-543)ACG>ATG	p.T181M		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	181	KH 2.					nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		GCCGCTGACCGTCACCACGCG	0.632													20	40					0	0	0	0	A	46444058	A	A	46444058	3	1	294	1	0	0	0	0	1	0	0	0	10609	1145	40	1	940	1	NOVA2	19	46444058	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	172668	46444058	12684925	328	54329											
IRF3	3661	broad.mit.edu	37	chr19	50166762	50166765	+	Frame_Shift_Del	DEL	CGGC	-	-																															aacatatgcaccagtggcctCggcccaggcctggggcaaca																								rs112234580		TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:50166762_50166765delCGGC	uc010end.1	-	3	554_557	c.172_175delGCCG	c.(172-177)GCCGAGfs	p.A58fs	IRF3_uc002pos.1_5'Flank|IRF3_uc002pot.1_Frame_Shift_Del_p.A58fs|IRF3_uc002pox.1_Frame_Shift_Del_p.A58fs|IRF3_uc002poy.1_Frame_Shift_Del_p.A58fs|IRF3_uc002pou.2_Frame_Shift_Del_p.A58fs|IRF3_uc002pov.2_5'UTR|IRF3_uc002pow.2_Frame_Shift_Del_p.A58fs|IRF3_uc002poz.1_Frame_Shift_Del_p.A58fs|IRF3_uc010ene.1_Intron|BCL2L12_uc002ppa.2_5'Flank|BCL2L12_uc002ppb.2_5'Flank	NM_001571	NP_001562	Q14653	IRF3_HUMAN	interferon regulatory factor 3	58_59	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.02)		CCAGTGGCCTCGGCCCAGGCCTGG	0.603													---	---	---								-	50166765	-	-	50166762	7	5	294	1	0	1	0	1	0	0	0	0	7870	893	31	0	1132	0	IRF3	19	50166762	Frame_Shift_Del	DEL	CGGC	TCGA-DQ-7595-01A-11D-2229-08	3722704	50166762	8962221	329	54330											
SIGLEC12	89858	broad.mit.edu	37	chr19	52004699	52004699	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atccttgttctgtgggtcccCaaggaggtggaatcggtccc	6	11	13	11	1	1	0	0	0	1	0	5	2	4	2	4	5	0	1	4	5	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:52004699C>A	uc002pwx.1	-	1	345	c.289G>T	c.(289-291)GGG>TGG	p.G97W	SIGLEC12_uc002pww.1_5'Flank|SIGLEC12_uc010eoy.1_5'UTR	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	97	Ig-like V-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGTGGGTCCCCAAGGAGGTGG	0.537													47	208					6.60958e-23	9.67423e-23	1	0	A	52004699	A	A	52004699	3	1	294	1	0	0	0	0	1	0	0	0	14373	594	21	4	1603	4	SIGLEC12	19	52004699	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1837937	52004699	7124284	330	54331											
ZNF577	84765	broad.mit.edu	37	chr19	52376427	52376427	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaggctttcccacacacactGcacccatagagtttctctcc	10	10	5	16	0	1	1	0	0	1	1	4	1	3	1	3	1	1	3	3	1	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:52376427G>T	uc010yde.1	-	7	1207	c.816C>A	c.(814-816)TGC>TGA	p.C272*	ZNF577_uc010ydd.1_Intron|ZNF577_uc002pxx.3_Nonsense_Mutation_p.C213*|ZNF577_uc002pxv.2_Nonsense_Mutation_p.C265*|ZNF577_uc002pxw.2_Nonsense_Mutation_p.C206*	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	272	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CACACACACTGCACCCATAGA	0.478													7	30					8.12818e-05	8.66051e-05	1	0	T	52376427	T	T	52376427	4	4	294	1	0	0	0	0	0	1	0	0	18076	1311	46	4	645	4	ZNF577	19	52376427	Nonsense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	371728	52376427	6752556	331	54332											
ZNF845	91664	broad.mit.edu	37	chr19	53848882	53848882	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attataggaacctggtctccCtgggtgaggataacttccct	9	12	10	10	0	1	1	0	1	1	0	3	3	2	3	3	4	2	0	3	4	4	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:53848882C>T	uc010ydv.1	+	3	256	c.139C>T	c.(139-141)CTG>TTG	p.L47L	ZNF845_uc010ydw.1_Silent_p.L47L	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCTGGTCTCCCTGGGTGAGGA	0.398													37	92					0	0	0	0	T	53848882	T	T	53848882	2	4	294	1	0	0	0	0	0	0	0	1	18258	680	24	4		4	ZNF845	19	53848882	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1472455	53848882	5280101	332	54333											
KIR3DL3	115653	broad.mit.edu	37	chr19	55246766	55246766	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgggacctcagtggtcatCatcccctttgctatcctcct	6	14	7	14	0	3	0	3	0	0	0	6	1	6	1	5	2	1	1	5	2	1	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:55246766C>T	uc002qgu.1	+	6	1014	c.996C>T	c.(994-996)ATC>ATT	p.I332I	KIR2DL3_uc002qgv.2_Intron	NM_153443	NP_703144	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three	332	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		CAGTGGTCATCATCCCCTTTG	0.483													26	63					0	0	0	0	T	55246766	T	T	55246766	2	4	294	1	0	0	0	0	0	0	0	1	8361	816	29	2		2	KIR3DL3	19	55246766	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1397884	55246766	3882217	333	54334											
PPP1R12C	54776	broad.mit.edu	37	chr19	55603243	55603243	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacgaatctctccagttccAggagggctggcctctcagcg	7	9	11	14	2	3	0	2	0	2	0	7	2	5	1	3	3	1	2	3	3	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:55603243A>T	uc002qix.2	-	20	2211	c.2195T>A	c.(2194-2196)CTG>CAG	p.L732Q	PPP1R12C_uc010yfs.1_Missense_Mutation_p.L657Q|PPP1R12C_uc002qiy.2_Missense_Mutation_p.L730Q	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	732	Potential.					cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CTCCAGTTCCAGGAGGGCTGG	0.602													51	193					0	0	0	0	T	55603243	T	T	55603243	3	4	294	1	0	0	0	0	1	0	0	0	12416	188	7	5	165	5	PPP1R12C	19	55603243	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	356477	55603243	3525740	334	54335											
ZNF470	388566	broad.mit.edu	37	chr19	57088549	57088549	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcttcaccaaagaattcataCaggagagaaaccctatgaat	17	9	6	9	0	3	3	2	1	1	2	3	5	3	4	2	1	2	0	2	1	6	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr19:57088549C>A	uc002qnl.3	+	6	1428	c.752C>A	c.(751-753)ACA>AAA	p.T251K	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AGAATTCATACAGGAGAGAAA	0.388													24	61					1.5548e-18	2.15633e-18	1	0	A	57088549	A	A	57088549	3	1	294	1	0	0	0	0	1	0	0	0	17996	478	17	4	766	4	ZNF470	19	57088549	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1485306	57088549	2040434	335	54336											
TCF15	6939	broad.mit.edu	37	chr20	590641	590642	+	Frame_Shift_Del	DEL	CC	-	-																															gctctgagtgcggtcccgctCccgcgcgttggccgcctgcc																										TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr20:590641_590642delCC	uc002wdz.2	-	1	269_270	c.240_241delGG	c.(238-243)CGGGAGfs	p.R80fs		NM_004609	NP_004600	Q12870	TCF15_HUMAN	basic helix-loop-helix transcription factor 15	80_81	Basic motif.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(17;0.231)				CGGTCCCGCTCCCGCGCGTTGg	0.376													---	---	---								-	590642	-	-	590641	7	5	294	1	0	1	0	1	0	0	0	0	15754	864	30	0	366	0	TCF15	20	590641	Frame_Shift_Del	DEL	CC	TCGA-DQ-7595-01A-11D-2229-08		590641	62434879	336	54337											
NKX2-2	4821	broad.mit.edu	37	chr20	21494085	21494085	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcggtgctggccagccagcGcgtgtacgggttgtcgctgc	3	9	16	13	5	0	0	0	0	0	0	2	0	0	0	2	3	5	4	2	3	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr20:21494085G>A	uc002wsi.2	-	1	580	c.223C>T	c.(223-225)CGC>TGC	p.R75C		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	75					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						GCCAGCCAGCGCGTGTACGGG	0.682													8	40					0	0	0	0	A	21494085	A	A	21494085	3	1	294	1	0	0	0	0	1	0	0	0	10504	1087	38	1	606	1	NKX2-2	20	21494085	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	20903444	21494085	41531435	337	54338											
CEP250	11190	broad.mit.edu	37	chr20	34061217	34061217	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aggacctaaggcagcagcttGcaggctgtcaagaggctgtg	10	7	15	9	0	1	1	1	0	0	1	1	2	1	2	1	4	3	6	1	4	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr20:34061217G>T	uc002xcm.2	+	14	1899	c.1228G>T	c.(1228-1230)GCA>TCA	p.A410S	CEP250_uc010zve.1_5'UTR|CEP250_uc010zvd.1_RNA	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	410	Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GCAGCAGCTTGCAGGCTGTCA	0.547													16	49					3.52763e-06	3.83596e-06	1	0	T	34061217	T	T	34061217	3	4	294	1	0	0	0	0	1	0	0	0	3267	1319	46	4	1266	4	CEP250	20	34061217	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	12567132	34061217	28964303	338	54339											
SLC2A10	81031	broad.mit.edu	37	chr20	45358126	45358126	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accagcagttccagaagagaCggtaggaagctgacagggtg	13	5	15	8	1	0	3	0	1	0	2	1	5	1	4	2	3	2	4	2	3	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr20:45358126C>T	uc002xsl.2	+	4	1643	c.1546C>T	c.(1546-1548)CGG>TGG	p.R516W		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	516	Cytoplasmic (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CCAGAAGAGACGGTAGGAAGC	0.527													13	49					0	0	0	0	T	45358126	T	T	45358126	3	4	294	1	0	0	0	0	1	0	0	0	14603	550	19	1	1560	1	SLC2A10	20	45358126	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	11296909	45358126	17667394	339	54340											
ZNF831	128611	broad.mit.edu	37	chr20	57768622	57768622	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ccccaggtgggcccacgcagCctgcctctttgtcatcccag	5	8	10	18	1	2	0	1	0	1	0	3	0	3	0	6	2	2	1	6	2	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr20:57768622C>A	uc002yan.2	+	1	2548	c.2548C>A	c.(2548-2550)CCT>ACT	p.P850T		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	850						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GCCCACGCAGCCTGCCTCTTT	0.637													26	89					8.88839e-20	1.26592e-19	1	0	A	57768622	A	A	57768622	3	1	294	1	0	0	0	0	1	0	0	0	18252	739	26	4	2550	4	ZNF831	20	57768622	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	12410496	57768622	5256898	340	54341											
SLC17A9	63910	broad.mit.edu	37	chr20	61588215	61588215	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaccgtctccatgagccAggacttcggctggaacaaga	10	7	11	13	2	1	2	0	1	1	1	3	4	1	4	3	3	3	2	3	3	2	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr20:61588215A>G	uc002yea.3	+	2	342	c.158A>G	c.(157-159)CAG>CGG	p.Q53R	SLC17A9_uc002ydz.3_Missense_Mutation_p.Q47R|SLC17A9_uc011aap.1_Missense_Mutation_p.Q73R	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	53					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						TCCATGAGCCAGGACTTCGGC	0.652													19	43					0	0	0	0	G	61588215	G	G	61588215	3	3	294	1	0	0	0	0	1	0	0	0	14489	188	7	5	164	5	SLC17A9	20	61588215	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	3819593	61588215	1437305	341	54342											
C20orf135	140701	broad.mit.edu	37	chr20	62493542	62493542	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcactggcgtgcccttccctCagcacgacgccaacgccatg	7	6	10	18	4	1	0	1	0	0	0	2	1	2	0	4	1	3	2	4	1	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr20:62493542C>T	uc002ygx.1	+	1	977	c.649C>T	c.(649-651)CAG>TAG	p.Q217*		NM_080622	NP_542189	Q9H3Z7	ABHGB_HUMAN	hypothetical protein LOC140701	217							hydrolase activity				0	all_cancers(38;1.77e-12)|all_epithelial(29;3.12e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					GCCCTTCCCTCAGCACGACGC	0.682													12	42					0	0	0	0	T	62493542	T	T	62493542	4	4	294	1	0	0	0	0	0	1	0	0	2098	827	29	2	651	2	C20orf135	20	62493542	Nonsense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	905327	62493542	531978	342	54343											
TRPM2	7226	broad.mit.edu	37	chr21	45826570	45826570	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctcatccacaacgagcgcCgggtggactggctgttccga	7	8	12	14	4	1	0	1	0	0	0	4	3	4	1	4	3	2	2	4	3	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr21:45826570C>T	uc002zet.1	+	20	3097	c.2884C>T	c.(2884-2886)CGG>TGG	p.R962W	TRPM2_uc002zeu.1_Missense_Mutation_p.R962W|TRPM2_uc002zew.1_Missense_Mutation_p.R962W|TRPM2_uc010gpt.1_Missense_Mutation_p.R962W|TRPM2_uc002zex.1_Missense_Mutation_p.R748W|TRPM2_uc002zey.1_Missense_Mutation_p.R475W	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	962	Extracellular (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAACGAGCGCCGGGTGGACTG	0.632													8	29					0	0	0	0	T	45826570	T	T	45826570	3	4	294	1	0	0	0	0	1	0	0	0	16653	643	23	1	2958	1	TRPM2	21	45826570	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08		45826570	2303325	343	54344											
DIP2A	23181	broad.mit.edu	37	chr21	47987506	47987506	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gcttcctggctgaccagctgGaccccatctatgtcgcctac	6	10	9	16	1	1	1	0	1	1	0	3	2	2	2	5	2	2	3	5	2	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr21:47987506G>C	uc002zjo.2	+	38	4870	c.4687G>C	c.(4687-4689)GAC>CAC	p.D1563H	DIP2A_uc011afz.1_Missense_Mutation_p.D1559H|DIP2A_uc002zjs.2_Missense_Mutation_p.D243H|DIP2A_uc002zjt.2_RNA	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	1563					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		TGACCAGCTGGACCCCATCTA	0.617													24	106					0	0	0	0	C	47987506	C	C	47987506	3	2	294	1	0	0	0	0	1	0	0	0	4549	1174	41	2	4950	2	DIP2A	21	47987506	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2160936	47987506	142389	344	54345											
BID	637	broad.mit.edu	37	chr22	18222145	18222145	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cggctggtgttcctgagctgCagggccaggccgttcaccag	5	8	15	13	2	1	1	1	1	0	0	2	1	2	1	4	4	2	5	4	4	0	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr22:18222145C>A	uc002znd.1	-	4	503	c.333G>T	c.(331-333)CTG>CTT	p.L111L	BID_uc002znc.1_Silent_p.L157L|BID_uc002zne.1_Silent_p.L15L|BID_uc010gra.1_RNA|BID_uc002znf.1_Silent_p.L15L|BID_uc010grb.1_Silent_p.L111L|BID_uc010grc.1_Silent_p.L15L	NM_001196	NP_001187	P55957	BID_HUMAN	BH3 interacting domain death agonist isoform 2	111					activation of pro-apoptotic gene products|establishment of protein localization in membrane|induction of apoptosis by intracellular signals|induction of apoptosis via death domain receptors|neuron apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|release of cytochrome c from mitochondria	cytosol|membrane fraction|mitochondrial outer membrane	death receptor binding				0		all_epithelial(15;0.198)		Lung(27;0.0419)		TCCTGAGCTGCAGGGCCAGGC	0.662													8	21					0.00307968	0.0031619	1	0	A	18222145	A	A	18222145	2	1	294	1	0	0	0	0	0	0	0	1	1433	697	25	4		4	BID	22	18222145	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08		18222145	33082421	345	54346											
CHEK2	11200	broad.mit.edu	37	chr22	29090106	29090106	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttcttgacaaggtccagagCtaaagcaacaattgggcaaa	15	8	9	9	0	1	2	0	1	1	1	2	2	2	2	1	2	3	3	1	2	6	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr22:29090106C>T	uc003adu.1	-	13	1448	c.1376_splice	c.e13-1	p.A459_splice	CHEK2_uc003ads.1_Splice_Site_p.A238_splice|CHEK2_uc010gvh.1_Splice_Site_p.A368_splice|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_Splice_Site|CHEK2_uc010gvk.1_Splice_Site|CHEK2_uc003adt.1_Splice_Site_p.A502_splice|CHEK2_uc003adv.1_Splice_Site_p.A430_splice|CHEK2_uc003adw.1_Splice_Site_p.A459_splice|CHEK2_uc003adx.1_Splice_Site_p.A238_splice|CHEK2_uc003ady.1_Splice_Site_p.A448_splice|CHEK2_uc003adz.1_Splice_Site_p.A263_splice	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a						cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						AGGTCCAGAGCTAAAGCAACA	0.448			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				49	140					0	0	0	0	T	29090106	T	T	29090106	5	4	294	1	0	0	0	0	0	0	1	0	3350	811	28	4	268	4	CHEK2	22	29090106	Splice_Site	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	10867961	29090106	22214460	346	54347											
APOL1	8542	broad.mit.edu	37	chr22	36661941	36661941	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggatgtagtctacctcgtGtacgaatcaaagcacttaca	12	11	8	10	2	2	0	1	0	1	0	3	2	2	1	1	1	4	3	1	1	6	4			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr22:36661941G>T	uc003apf.2	+	6	1227	c.1059G>T	c.(1057-1059)GTG>GTT	p.V353V	APOL1_uc011amn.1_Silent_p.V230V|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Silent_p.V369V|APOL1_uc011amo.1_Silent_p.V230V|APOL1_uc011amp.1_Silent_p.V353V|APOL1_uc011amq.1_Silent_p.V335V|APOL1_uc010gwx.2_Silent_p.V230V	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	353					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						TCTACCTCGTGTACGAATCAA	0.502													26	71					1.1804e-14	1.53162e-14	1	0	T	36661941	T	T	36661941	2	4	294	1	0	0	0	0	0	0	0	1	805	1364	48	4		4	APOL1	22	36661941	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	7571835	36661941	14642625	347	54348											
CARD10	29775	broad.mit.edu	37	chr22	37891531	37891531	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagccgtgctcacattactgCgggggcctcggtgccggctg	4	8	15	14	4	1	0	1	0	0	0	2	0	1	0	3	4	5	2	3	4	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr22:37891531C>A	uc003asx.1	-	15	2369	c.2366G>T	c.(2365-2367)CGC>CTC	p.R789L	CARD10_uc003ast.1_RNA|CARD10_uc003asu.1_5'Flank|CARD10_uc003asv.1_5'Flank|CARD10_uc011ank.1_Missense_Mutation_p.R107L|CARD10_uc003asw.1_Missense_Mutation_p.R503L|CARD10_uc003asy.1_Missense_Mutation_p.R789L	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	789					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					CACATTACTGCGGGGGCCTCG	0.607													7	17					0.000157383	0.000166018	1	0	A	37891531	A	A	37891531	3	1	294	1	0	0	0	0	1	0	0	0	2656	768	27	3	756	3	CARD10	22	37891531	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1229590	37891531	13413035	348	54349											
DMC1	11144	broad.mit.edu	37	chr22	38948700	38948700	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tatgagaaagctgggtttttCcagtacgaaattctgtgaaa	13	13	10	5	1	1	2	0	2	1	1	2	4	2	2	1	1	2	3	1	1	5	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr22:38948700C>A	uc003avz.1	-	7	567	c.392G>T	c.(391-393)GGA>GTA	p.G131V	DMC1_uc011anv.1_Missense_Mutation_p.G131V|DMC1_uc003awa.1_Missense_Mutation_p.G131V	NM_007068	NP_008999	Q14565	DMC1_HUMAN	DMC1 dosage suppressor of mck1 homolog	131	ATP (Potential).				reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)					CTGGGTTTTTCCAGTACGAAA	0.289								Homologous_recombination					17	51					1.67942e-08	1.94628e-08	1	0	A	38948700	A	A	38948700	3	1	294	1	0	0	0	0	1	0	0	0	4601	855	30	2	662	2	DMC1	22	38948700	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1057169	38948700	12355866	349	54350											
MGAT3	4248	broad.mit.edu	37	chr22	39884457	39884457	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaggctgcacggtggacAtgctgcaggcagtgtatggg	7	9	17	8	1	1	0	1	0	0	0	1	1	1	1	0	5	3	6	0	5	1	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr22:39884457A>T	uc003axv.3	+	2	1344	c.1105A>T	c.(1105-1107)ATG>TTG	p.M369L	MGAT3_uc010gxy.2_Missense_Mutation_p.M369L	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	369	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					CACGGTGGACATGCTGCAGGC	0.632													46	138					0	0	0	0	T	39884457	T	T	39884457	3	4	294	1	0	0	0	0	1	0	0	0	9597	217	8	5	1107	5	MGAT3	22	39884457	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	935757	39884457	11420109	350	54351											
EP300	2033	broad.mit.edu	37	chr22	41572275	41572275	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctttgtgatccgcctcattGctggccctgctgccaactcc	4	13	8	16	1	2	1	1	1	1	0	4	1	4	1	5	1	4	2	5	1	1	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr22:41572275G>T	uc003azl.3	+	30	5199	c.4804G>T	c.(4804-4806)GCT>TCT	p.A1602S		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1602	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CCGCCTCATTGCTGGCCCTGC	0.393			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				65	187					6.43283e-47	9.96735e-47	1	0	T	41572275	T	T	41572275	3	4	294	1	0	0	0	0	1	0	0	0	5172	1319	46	4	4922	4	EP300	22	41572275	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1687818	41572275	9732291	351	54352											
PMM1	5372	broad.mit.edu	37	chr22	41980050	41980050	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcatgccattccggaactcGatgaaggttccactggtggt	9	10	12	10	2	0	1	0	1	0	0	3	3	2	2	3	4	3	2	3	4	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr22:41980050G>A	uc003bal.2	-	5	449	c.387C>T	c.(385-387)ATC>ATT	p.I129I		NM_002676	NP_002667	Q92871	PMM1_HUMAN	phosphomannomutase 1	129					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			ovary(1)	1						TCCGGAACTCGATGAAGGTTC	0.582													44	141					0	0	0	0	A	41980050	A	A	41980050	2	1	294	1	0	0	0	0	0	0	0	1	12191	1048	37	1		1	PMM1	22	41980050	Silent	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	407775	41980050	9324516	352	54353											
PHF21B	112885	broad.mit.edu	37	chr22	45281353	45281353	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgctcctccagctgctggtGctcgttctgcagctcactgc	3	11	10	17	2	2	0	1	0	1	0	5	0	4	0	3	1	6	7	3	1	0	1			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr22:45281353G>T	uc003bfn.2	-	12	1481	c.1330C>A	c.(1330-1332)CAC>AAC	p.H444N	PHF21B_uc003bfm.2_Missense_Mutation_p.H240N|PHF21B_uc011aqk.1_Missense_Mutation_p.H390N|PHF21B_uc011aql.1_Missense_Mutation_p.H402N	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	444	Potential.						zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		AGCTGCTGGTGCTCGTTCTGC	0.657													4	6					0.00024832	0.000259998	1	0	T	45281353	T	T	45281353	3	4	294	1	0	0	0	0	1	0	0	0	11889	1319	46	4	273	4	PHF21B	22	45281353	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	3301303	45281353	6023213	353	54354											
PKDREJ	10343	broad.mit.edu	37	chr22	46655679	46655679	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggtcacggggttttggtGaaggctcttgatgatgttta	7	14	16	4	1	2	3	1	3	1	0	2	4	2	3	0	5	0	3	0	5	2	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chr22:46655679G>T	uc003bhh.2	-	1	3541	c.3541C>A	c.(3541-3543)CAC>AAC	p.H1181N		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1181	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GGGTTTTGGTGAAGGCTCTTG	0.473													44	134					2.64894e-19	3.76008e-19	1	0	T	46655679	T	T	46655679	3	4	294	1	0	0	0	0	1	0	0	0	12025	1290	45	2	3224	2	PKDREJ	22	46655679	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	1374326	46655679	4648887	354	54355											
SFRS17A	8227	broad.mit.edu	37	chrX	1720074	1720074	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	acaacaaccaacagcccaagGgcatccctgcctgcgagcag	13	3	9	16	1	0	0	0	0	0	0	1	1	1	0	4	1	7	2	4	1	4	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:1720074G>T	uc004cqa.2	+	5	1871	c.1675G>T	c.(1675-1677)GGC>TGC	p.G559C	SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_Intron	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	559					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACAGCCCAAGGGCATCCCTGC	0.647													26	85					5.77227e-19	8.05832e-19	1	0	T	1720074	T	T	1720074	3	4	294	1	0	0	0	0	1	0	0	0	14238	1232	43	4	1689	4	SFRS17A	23	1720074	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08		1720074	153550486	355	54356											
MAGEB18	286514	broad.mit.edu	37	chrX	26157626	26157626	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcccatcaggcactactatgCctttttcagcaaattagacc	11	12	5	13	0	2	1	2	0	0	1	3	1	3	1	3	1	3	2	3	1	4	5			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:26157626C>T	uc004dbq.1	+	2	711	c.524C>T	c.(523-525)GCC>GTC	p.A175V		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	175	MAGE.						protein binding			central_nervous_system(1)	1						CACTACTATGCCTTTTTCAGC	0.448													4	5					0	0	0	0	T	26157626	T	T	26157626	3	4	294	1	0	0	0	0	1	0	0	0	9228	739	26	4	526	4	MAGEB18	23	26157626	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	24437552	26157626	129112934	356	54357											
FAM47B	170062	broad.mit.edu	37	chrX	34961286	34961286	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctctcgccagtacagccagCacggaaggcgttcgtagagg	9	6	14	12	4	1	1	0	0	1	1	3	2	1	2	2	3	3	5	2	3	3	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:34961286C>A	uc004ddi.1	+	1	356	c.338C>A	c.(337-339)GCA>GAA	p.A113E		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	113										ovary(3)|breast(1)	4						GTACAGCCAGCACGGAAGGCG	0.522													18	31					4.96729e-08	5.69421e-08	1	0	A	34961286	A	A	34961286	3	1	294	1	0	0	0	0	1	0	0	0	5602	710	25	4	340	4	FAM47B	23	34961286	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	8803660	34961286	120309274	357	54358											
PLP2	5355	broad.mit.edu	37	chrX	49029611	49029611	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcacaccaagataccattcAtcaactggccctggagtgtg	11	9	9	12	0	2	1	2	0	0	1	2	2	2	2	3	2	3	1	3	2	3	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:49029611A>T	uc004dmx.2	+	2	307	c.232A>T	c.(232-234)ATC>TTC	p.I78F		NM_002668	NP_002659	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic	78	MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity				0						GATACCATTCATCAACTGGCC	0.527													11	22					0	0	0	0	T	49029611	T	T	49029611	3	4	294	1	0	0	0	0	1	0	0	0	12160	217	8	5	238	5	PLP2	23	49029611	Missense_Mutation	SNP	A	TCGA-DQ-7595-01A-11D-2229-08	14068325	49029611	106240949	358	54359											
FAM123B	139285	broad.mit.edu	37	chrX	63411371	63411371	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgccataagcctctcgagtaTaggcctccctggcgtgggcc	6	9	12	14	2	1	0	0	0	1	0	3	1	2	0	5	3	2	1	5	3	3	3	rs144896730	byFrequency	TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:63411371T>C	uc004dvo.2	-	2	2069	c.1796A>G	c.(1795-1797)TAT>TGT	p.Y599C		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	599					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CTCTCGAGTATAGGCCTCCCT	0.632													4	20					0	0	0	0	C	63411371	C	C	63411371	3	2	294	1	0	0	0	0	1	0	0	0	5451	1406	49	5	1615	5	FAM123B	23	63411371	Missense_Mutation	SNP	T	TCGA-DQ-7595-01A-11D-2229-08	14381760	63411371	91859189	359	54360											
HEPH	9843	broad.mit.edu	37	chrX	65420534	65420534	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agcttcagggcatgaggaagGgtgcagctatgctctttcct	8	11	13	9	0	2	1	1	1	1	0	3	2	3	2	1	3	4	5	1	3	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:65420534G>T	uc011moz.1	+	12	2086	c.2026G>T	c.(2026-2028)GGT>TGT	p.G676C	HEPH_uc004dwn.2_Missense_Mutation_p.G676C|HEPH_uc004dwo.2_Missense_Mutation_p.G406C|HEPH_uc010nkr.2_Intron|HEPH_uc011mpa.1_Missense_Mutation_p.G676C|HEPH_uc010nks.2_5'Flank	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	673	Plastocyanin-like 4.|Extracellular (Potential).				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						CATGAGGAAGGGTGCAGCTAT	0.557													14	21					1.15088e-07	1.2913e-07	1	0	T	65420534	T	T	65420534	3	4	294	1	0	0	0	0	1	0	0	0	7093	1232	43	4	2225	4	HEPH	23	65420534	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2009163	65420534	89850026	360	54361											
HEPH	9843	broad.mit.edu	37	chrX	65476077	65476077	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttgatgaaaataagtcttGgtatttggaggaaaatgtgg	13	15	12	1	0	1	2	0	2	1	0	1	4	1	4	0	4	0	1	0	4	6	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:65476077G>T	uc011moz.1	+	17	2870	c.2810G>T	c.(2809-2811)TGG>TTG	p.W937L	HEPH_uc004dwn.2_Missense_Mutation_p.W937L|HEPH_uc004dwo.2_Missense_Mutation_p.W667L|HEPH_uc010nkr.2_Missense_Mutation_p.W745L|HEPH_uc011mpa.1_Missense_Mutation_p.W937L|HEPH_uc010nks.2_Missense_Mutation_p.W226L	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	934	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						AATAAGTCTTGGTATTTGGAG	0.453													26	36					1.16021e-09	1.37856e-09	1	0	T	65476077	T	T	65476077	3	4	294	1	0	0	0	0	1	0	0	0	7093	1357	47	4	3029	4	HEPH	23	65476077	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	55543	65476077	89794483	361	54362											
AR	367	broad.mit.edu	37	chrX	66931443	66931443	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacacgacaacaaccagccCgactcctttgcagccttgct	10	7	8	16	2	0	0	0	0	0	0	1	3	1	1	4	1	6	2	4	1	2	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:66931443C>T	uc004dwu.1	+	4	3200	c.2085C>T	c.(2083-2085)CCC>CCT	p.P695P	AR_uc004dwv.1_Silent_p.P163P	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	694	Ligand-binding.|Interaction with MYST2.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	ACAACCAGCCCGACTCCTTTG	0.522									Androgen_Insensitivity_Syndrome				6	27					0	0	0	0	T	66931443	T	T	66931443	2	4	294	1	0	0	0	0	0	0	0	1	836	639	23	1		1	AR	23	66931443	Silent	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	1455366	66931443	88339117	362	54363											
KLHL4	56062	broad.mit.edu	37	chrX	86869564	86869564	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taaattccttggtgcagtatGcttacacaggtaagtgccaa	12	12	9	8	0	0	0	0	0	0	0	1	0	1	0	2	2	4	4	2	2	6	6			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:86869564G>A	uc004efb.2	+	3	900	c.718G>A	c.(718-720)GCT>ACT	p.A240T	KLHL4_uc004efa.2_Missense_Mutation_p.A240T	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	240	BTB.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GGTGCAGTATGCTTACACAGG	0.348													18	20					0	0	0	0	A	86869564	A	A	86869564	3	1	294	1	0	0	0	0	1	0	0	0	8430	1319	46	4	728	4	KLHL4	23	86869564	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	19938121	86869564	68400996	363	54364											
GLA	2717	broad.mit.edu	37	chrX	100652942	100652943	+	In_Frame_Ins	INS	-	AGG	AGG																															gaggagctgtgtgatgaagcINSaggcaggattacaggccact																								rs113993943		TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:100652942_100652943insAGG	uc004ehl.1	-	7	1254_1255	c.1144_1145insCCT	c.(1144-1146)TGC>TCCTGC	p.381_382insS		NM_000169	NP_000160	P06280	AGAL_HUMAN	alpha-galactosidase A precursor	381_382					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding				0					Agalsidase beta(DB00103)	TGTGATGAAGCAGGCAGGATTA	0.49													---	---	---								AGG	100652943	AGG	AGG	100652942	7	5	294	1	0	1	1	0	0	0	0	0	6463	710	25	0	148	0	GLA	23	100652942	In_Frame_Ins	INS	-	TCGA-DQ-7595-01A-11D-2229-08	13783378	100652942	54617618	364	54365											
PLP1	5354	broad.mit.edu	37	chrX	103041641	103041641	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	attgtttgggaaaatggctaGgacatcccgacaaggtgatc	12	10	12	7	1	0	1	0	1	0	0	2	4	1	3	1	4	0	2	1	4	4	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:103041641G>A	uc010nov.2	+	4	719	c.439G>A	c.(439-441)GGA>AGA	p.G147R	RAB9B_uc004eli.1_Intron|PLP1_uc004elk.2_Missense_Mutation_p.G147R|PLP1_uc004elj.2_Intron|PLP1_uc011msf.1_Missense_Mutation_p.G92R|PLP1_uc010now.1_Missense_Mutation_p.G151R|PLP1_uc010nox.2_Missense_Mutation_p.G101R	NM_001128834	NP_001122306	P60201	MYPR_HUMAN	proteolipid protein 1 isoform 1	147	Cytoplasmic (Probable).		Missing (in HLD1).		cell death|synaptic transmission	integral to membrane				ovary(1)	1						AAAATGGCTAGGACATCCCGA	0.562													74	74					0	0	0	0	A	103041641	A	A	103041641	3	1	294	1	0	0	0	0	1	0	0	0	12159	1001	35	4	449	4	PLP1	23	103041641	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2388699	103041641	52228919	365	54366											
SAGE1	55511	broad.mit.edu	37	chrX	134988621	134988621	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagatggaaaatgtccaacCagcacctgataacgtgttgt	14	9	10	8	1	0	2	0	1	0	1	1	4	1	3	3	1	3	2	3	1	5	2			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:134988621C>T	uc004ezh.2	+	7	814	c.647C>T	c.(646-648)CCA>CTA	p.P216L	SAGE1_uc010nry.1_Missense_Mutation_p.P185L|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	216										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AATGTCCAACCAGCACCTGAT	0.443													45	158					0	0	0	0	T	134988621	T	T	134988621	3	4	294	1	0	0	0	0	1	0	0	0	13874	594	21	4	669	4	SAGE1	23	134988621	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	31946980	134988621	20281939	366	54367											
SPANXN2	494119	broad.mit.edu	37	chrX	142795403	142795403	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctcctgtgaagatccttcaGctgagtctaggccttcgtcc	6	12	9	14	1	2	3	1	2	1	1	6	3	5	3	5	1	1	1	5	1	2	3			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:142795403G>A	uc004fbz.2	-	2	1029	c.275C>T	c.(274-276)GCT>GTT	p.A92V		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	92										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					AGATCCTTCAGCTGAGTCTAG	0.498													150	156					0	0	0	0	A	142795403	A	A	142795403	3	1	294	1	0	0	0	0	1	0	0	0	15057	971	34	4	271	4	SPANXN2	23	142795403	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	7806782	142795403	12475157	367	54368											
SLITRK2	84631	broad.mit.edu	37	chrX	144904886	144904886	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatcgtccaactcctcgaGtgactgtgtcaaaggacagg	12	8	11	10	2	1	1	1	1	0	0	5	4	3	2	2	2	1	0	2	2	3	0			TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:144904886G>T	uc004fcd.2	+	5	1933	c.943G>T	c.(943-945)GTG>TTG	p.V315L	SLITRK2_uc010nsp.2_Missense_Mutation_p.V315L|SLITRK2_uc010nso.2_Missense_Mutation_p.V315L|SLITRK2_uc011mwq.1_Missense_Mutation_p.V315L|SLITRK2_uc011mwr.1_Missense_Mutation_p.V315L|SLITRK2_uc011mws.1_Missense_Mutation_p.V315L|SLITRK2_uc004fcg.2_Missense_Mutation_p.V315L|SLITRK2_uc011mwt.1_Missense_Mutation_p.V315L	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	315	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					AACTCCTCGAGTGACTGTGTC	0.552													22	23					7.07758e-08	8.02632e-08	1	0	T	144904886	T	T	144904886	3	4	294	1	0	0	0	0	1	0	0	0	14807	1029	36	4	945	4	SLITRK2	23	144904886	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	2109483	144904886	10365674	368	54369											
OPN1MW	2652	broad.mit.edu	37	chrX	153496125	153496125	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttctgctggggaccctacGccttcttcgcatgctttgct	3	14	10	14	2	2	0	0	0	2	0	3	1	2	1	2	2	4	5	2	2	1	5	rs1065438	byFrequency	TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:153496125G>A	uc004fkd.2	+	5	935	c.853G>A	c.(853-855)GCC>ACC	p.A285T		NM_000513	NP_000504	P04001	OPSG_HUMAN	opsin 1 (cone pigments), medium-wave-sensitive	285	Helical; Name=6; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGACCCTACGCCTTCTTCGC	0.567													20	0					0	0	0	0	A	153496125	A	A	153496125	3	1	294	1	0	0	0	0	1	0	0	0	10932	1087	38	1	1990	1	OPN1MW	23	153496125	Missense_Mutation	SNP	G	TCGA-DQ-7595-01A-11D-2229-08	8591239	153496125	1774435	369	54370											
PLXNA3	55558	broad.mit.edu	37	chrX	153688695	153688695	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	accgagtctttaagctggccCccaacctgactgagctgcgg	8	8	11	14	2	1	2	0	2	1	0	1	3	1	2	4	2	4	2	4	2	2	2	rs147019078	byFrequency	TCGA-DQ-7595-01A-11D-2229-08	TCGA-DQ-7595-10D-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d504cd7-09f0-4691-a1b2-55fc7d206439	b22ca993-a7fe-4ef4-97b2-92319beec503	g.chrX:153688695C>T	uc004flm.2	+	2	345	c.172C>T	c.(172-174)CCC>TCC	p.P58S		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	58	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TAAGCTGGCCCCCAACCTGAC	0.672													7	34					0	0	0	0	T	153688695	T	T	153688695	3	4	294	1	0	0	0	0	1	0	0	0	12176	623	22	4	174	4	PLXNA3	23	153688695	Missense_Mutation	SNP	C	TCGA-DQ-7595-01A-11D-2229-08	192570	153688695	1581865	370	54371											
MEGF6	1953	broad.mit.edu	37	chr1	3418409	3418409	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcggacaccggcactgcccCgtgaccccgtggcagggggc	5	3	17	16	4	0	1	0	1	0	0	0	2	0	2	5	6	1	2	5	6	0	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:3418409C>G	uc001akl.2	-	18	2492	c.2265G>C	c.(2263-2265)ACG>ACC	p.T755T	MEGF6_uc001akk.2_Silent_p.T650T	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	755	EGF-like 12.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GGCACTGCCCCGTGACCCCGT	0.706													15	27					0	0	0	0	G	3418409	G	G	3418409	2	3	295	1	0	0	0	0	0	0	0	1	9515	639	23	3		3	MEGF6	1	3418409	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08		3418409	245832212	1	54372											
PER3	8863	broad.mit.edu	37	chr1	7895935	7895935	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaacatttcctaatgtcgccGaagagcccatctggagaatg	13	9	9	10	2	1	2	0	0	1	2	3	4	2	2	3	1	2	0	3	1	4	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:7895935G>A	uc001aoo.2	+	19	3476	c.3301G>A	c.(3301-3303)GAA>AAA	p.E1101K	PER3_uc001aop.2_Missense_Mutation_p.E1110K|PER3_uc010nzw.1_Missense_Mutation_p.E790K	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	1101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TAATGTCGCCGAAGAGCCCAT	0.418													21	35					0	0	0	0	A	7895935	A	A	7895935	3	1	295	1	0	0	0	0	1	0	0	0	11785	1059	37	1	3375	1	PER3	1	7895935	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	4477526	7895935	241354686	2	54373											
RIMS3	9783	broad.mit.edu	37	chr1	41094945	41094945	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttccaaaatccctcacctGggagggatttggagcctggt	9	11	11	10	0	1	0	1	0	0	0	3	3	3	3	4	4	1	0	4	4	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:41094945G>C	uc001cfu.1	-	6	1041	c.572C>G	c.(571-573)CCA>CGA	p.P191R	RIMS3_uc001cfv.1_Missense_Mutation_p.P191R	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	191	C2.				neurotransmitter transport	cell junction|synapse					0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			TCCCTCACCTGGGAGGGATTT	0.592													32	110					0	0	0	0	C	41094945	C	C	41094945	3	2	295	1	0	0	0	0	1	0	0	0	13434	1348	47	4	366	4	RIMS3	1	41094945	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	33199010	41094945	208155676	3	54374											
RNF220	55182	broad.mit.edu	37	chr1	44878355	44878355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctctggcctcatttctgatCgggaagcctcatctagccca	7	12	8	14	1	5	1	2	1	3	0	7	2	5	2	3	2	2	0	3	2	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:44878355C>T	uc001clv.1	+	2	946	c.586C>T	c.(586-588)CGG>TGG	p.R196W	RNF220_uc001clw.1_Missense_Mutation_p.R196W	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	196					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CATTTCTGATCGGGAAGCCTC	0.512													46	92					0	0	0	0	T	44878355	T	T	44878355	3	4	295	1	0	0	0	0	1	0	0	0	13548	875	31	1	588	1	RNF220	1	44878355	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	3783410	44878355	204372266	4	54375											
SSBP3	23648	broad.mit.edu	37	chr1	54722843	54722843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctggggccgcctgcgtatCgcggtgacataaaaggctgc	7	7	15	12	4	0	1	0	1	0	0	1	1	0	1	3	4	2	2	3	4	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:54722843C>T	uc001cxe.2	-	7	762	c.464G>A	c.(463-465)CGA>CAA	p.R155Q	SSBP3_uc001cxf.2_Intron|SSBP3_uc001cxg.2_Missense_Mutation_p.R128Q	NM_145716	NP_663768	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3 isoform a	155	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding				0						GCCTGCGTATCGCGGTGACAT	0.522													7	21					0	0	0	0	T	54722843	T	T	54722843	3	4	295	1	0	0	0	0	1	0	0	0	15247	884	31	1	750	1	SSBP3	1	54722843	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	9844488	54722843	194527778	5	54376											
DAB1	1600	broad.mit.edu	37	chr1	57610988	57610988	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtttcatcatggaatcttgaCataacttgtctccccgagct	9	14	7	11	1	4	1	2	1	2	0	5	3	4	2	2	1	2	2	2	1	2	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:57610988C>T	uc001cys.1	-	5	856	c.182G>A	c.(181-183)TGT>TAT	p.C61Y	DAB1_uc001cyt.1_Missense_Mutation_p.C61Y|DAB1_uc001cyq.1_Missense_Mutation_p.C61Y|DAB1_uc001cyr.1_Missense_Mutation_p.C61Y|DAB1_uc009vzw.1_Missense_Mutation_p.C61Y|DAB1_uc009vzx.1_Missense_Mutation_p.C61Y	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	61	PID.				cell differentiation|nervous system development					skin(2)|ovary(1)	3						GGAATCTTGACATAACTTGTC	0.393													15	65					0	0	0	0	T	57610988	T	T	57610988	3	4	295	1	0	0	0	0	1	0	0	0	4234	478	17	4	1533	4	DAB1	1	57610988	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2888145	57610988	191639633	6	54377											
PGM1	5236	broad.mit.edu	37	chr1	64100692	64100693	+	Splice_Site	INS	-	G	G																															gcctttgatggagatggggtINSgggtataagtgcatttaagt																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:64100692_64100693insG	uc001dbh.2	+	5	1086	c.873_splice	c.e5+2	p.G291_splice	PGM1_uc010ooy.1_Splice_Site_p.G94_splice|PGM1_uc010ooz.1_Splice_Site_p.G309_splice	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1						cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						GGAGATGGGGTGGGTATAAGTG	0.545													---	---	---								G	64100693	G	G	64100692	8	5	295	1	0	1	1	0	0	0	1	0	11852	1710	59	0	1197	0	PGM1	1	64100692	Splice_Site	INS	-	TCGA-F7-7848-01A-11D-2129-08	6489704	64100692	185149929	7	54378											
IL12RB2	3595	broad.mit.edu	37	chr1	67861293	67861294	+	Missense_Mutation	DNP	CC	AA	AA																															ccacgcctgaagatcctgaaCcgctggtcatcagtgaagtc																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:67861293_67861294CC>AA	uc001ddu.2	+	16	2750_2751	c.2110_2111CC>AA	c.(2110-2112)CCG>AAG	p.P704K	IL12RB2_uc010oqi.1_3'UTR|IL12RB2_uc010oqj.1_3'UTR|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.P618K|IL12RB2_uc010oqm.1_3'UTR|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	704	Cytoplasmic (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						AGATCCTGAACCGCTGGTCATC	0.54													17	60					0	0	0	0	AA	67861294	AA	AA	67861293	3	1	295	1	0	0	0	0	1	0	0	0	7666	507	18	4	2168	4	IL12RB2	1	67861293	Missense_Mutation	DNP	CC	TCGA-F7-7848-01A-11D-2129-08	3760601	67861293	181389328	8	54379											
IFI44L	10964	broad.mit.edu	37	chr1	79093945	79093945	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatgagcaactggtgtgtcgTttatcgaaaacggatatttt	11	14	11	5	3	0	1	0	1	0	0	2	4	0	2	0	2	3	2	0	2	5	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:79093945T>C	uc010oro.1	+	2	524	c.345T>C	c.(343-345)CGT>CGC	p.R115R	IFI44L_uc010orp.1_Intron|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	115						cytoplasm					0						TGGTGTGTCGTTTATCGAAAA	0.313													8	26					0	0	0	0	C	79093945	C	C	79093945	2	2	295	1	0	0	0	0	0	0	0	1	7557	1712	60	5		5	IFI44L	1	79093945	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	11232652	79093945	170156676	9	54380											
ELTD1	64123	broad.mit.edu	37	chr1	79385874	79385874	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggatgcctacataccttattAgtatttgtattgatcccaac	11	15	6	9	0	0	1	0	1	0	0	1	2	1	2	3	1	4	2	3	1	7	8			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:79385874A>T	uc001diq.3	-	10	1611	c.1455T>A	c.(1453-1455)ACT>ACA	p.T485T		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	485	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		ATACCTTATTAGTATTTGTAT	0.313													10	18					0	0	0	0	T	79385874	T	T	79385874	2	4	295	1	0	0	0	0	0	0	0	1	5108	407	15	5		5	ELTD1	1	79385874	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	291929	79385874	169864747	10	54381											
COL24A1	255631	broad.mit.edu	37	chr1	86210435	86210435	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagaggattcttgatgctgTgcaataaattgctaaggtag	13	12	11	5	0	1	2	0	1	1	1	1	3	1	3	0	2	3	4	0	2	6	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:86210435T>C	uc001dlj.2	-	57	4628	c.4586A>G	c.(4585-4587)CAC>CGC	p.H1529R	COL24A1_uc001dli.2_Missense_Mutation_p.H644R|COL24A1_uc010osd.1_Missense_Mutation_p.H829R|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1529	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTTGATGCTGTGCAATAAATT	0.388													23	63					0	0	0	0	C	86210435	C	C	86210435	3	2	295	1	0	0	0	0	1	0	0	0	3698	1696	59	5	574	5	COL24A1	1	86210435	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	6824561	86210435	163040186	11	54382											
PKN2	5586	broad.mit.edu	37	chr1	89271325	89271325	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acagtgccagtggttgatgtAcgcatccctcaactagcacc	10	9	9	13	1	1	1	1	1	0	0	2	1	2	1	3	1	4	4	3	1	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:89271325A>T	uc001dmn.2	+	11	1989	c.1647A>T	c.(1645-1647)GTA>GTT	p.V549V	PKN2_uc001dmm.1_Silent_p.V549V|PKN2_uc010osp.1_Silent_p.V533V|PKN2_uc010osq.1_Silent_p.V392V|PKN2_uc009wcv.2_Silent_p.V501V|PKN2_uc010osr.1_Silent_p.V214V	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	549					signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		TGGTTGATGTACGCATCCCTC	0.448													5	32					0	0	0	0	T	89271325	T	T	89271325	2	4	295	1	0	0	0	0	0	0	0	1	12035	378	14	5		5	PKN2	1	89271325	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	3060890	89271325	159979296	12	54383											
ABCD3	5825	broad.mit.edu	37	chr1	94964203	94964203	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttgtggtccaaatggctgcGgaaagagttcacttttccgt	8	14	11	8	2	1	1	1	0	0	1	3	2	3	2	2	3	1	2	2	3	2	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:94964203G>T	uc001dqn.3	+	17	1534	c.1432G>T	c.(1432-1434)GGA>TGA	p.G478*	ABCD3_uc010oto.1_Nonsense_Mutation_p.G502*|ABCD3_uc010otp.1_Nonsense_Mutation_p.G405*|ABCD3_uc009wdr.2_Nonsense_Mutation_p.G368*|ABCD3_uc001dqo.3_Nonsense_Mutation_p.G166*	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	478	ATP (Potential).|ABC transporter.			G->R: Decreased ATP-binding affinity.	peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		AAATGGCTGCGGAAAGAGTTC	0.343													11	43					5.50884e-06	6.05025e-06	1	0	T	94964203	T	T	94964203	4	4	295	1	0	0	0	0	0	1	0	0	62	1117	39	3	1529	3	ABCD3	1	94964203	Nonsense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	5692878	94964203	154286418	13	54384											
OLFM3	118427	broad.mit.edu	37	chr1	102290738	102290738	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgggtgattaacttagcatCtgttttgtactgttccagca	8	16	9	8	0	1	1	0	1	1	0	2	1	2	1	1	1	4	5	1	1	3	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:102290738C>A	uc001duf.2	-	4	567	c.496G>T	c.(496-498)GAT>TAT	p.D166Y	OLFM3_uc001dug.2_Missense_Mutation_p.D146Y|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.D71Y|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	166	Potential.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		AACTTAGCATCTGTTTTGTAC	0.448													10	35					1.58986e-06	1.77224e-06	1	0	A	102290738	A	A	102290738	3	1	295	1	0	0	0	0	1	0	0	0	10908	913	32	2	952	2	OLFM3	1	102290738	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	7326535	102290738	146959883	14	54385											
COL11A1	1301	broad.mit.edu	37	chr1	103354181	103354182	+	Missense_Mutation	DNP	GG	TT	TT																															ctgtcacctttctggccagcGggtccctgttagaaagaaga																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:103354181_103354182GG>TT	uc001dul.2	-	62	4877_4878	c.4559_4560CC>AA	c.(4558-4560)CCC>CAA	p.P1520Q	COL11A1_uc001duk.2_Missense_Mutation_p.P716Q|COL11A1_uc001dum.2_Missense_Mutation_p.P1532Q|COL11A1_uc001dun.2_Missense_Mutation_p.P1481Q|COL11A1_uc009weh.2_Missense_Mutation_p.P1404Q	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1520	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCTGGCCAGCGGGTCCCTGTTA	0.416													8	36					0	0	0	0	TT	103354182	TT	TT	103354181	3	4	295	1	0	0	0	0	1	0	0	0	3682	1103	39	3	884	3	COL11A1	1	103354181	Missense_Mutation	DNP	GG	TCGA-F7-7848-01A-11D-2129-08	1063443	103354181	145896440	15	54386											
COL11A1	1301	broad.mit.edu	37	chr1	103468025	103468025	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttgacctggaggcccaggctCcccttggggaccctgccaga	6	7	13	15	0	0	2	0	1	0	1	1	4	1	4	6	5	1	1	6	5	0	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:103468025C>G	uc001dul.2	-	23	2374	c.2056G>C	c.(2056-2058)GAG>CAG	p.E686Q	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.E698Q|COL11A1_uc001dun.2_Missense_Mutation_p.E647Q|COL11A1_uc009weh.2_Missense_Mutation_p.E570Q	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	686	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGCCCAGGCTCCCCTTGGGGA	0.438													4	8					0	0	0	0	G	103468025	G	G	103468025	3	3	295	1	0	0	0	0	1	0	0	0	3682	864	30	2	3544	2	COL11A1	1	103468025	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	113844	103468025	145782596	16	54387											
DDX20	11218	broad.mit.edu	37	chr1	112305593	112305593	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatatgatgatgagaattGcccagaaatgtaatatcaac	19	10	7	5	0	1	4	1	3	0	2	1	5	1	4	1	0	2	1	1	0	8	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:112305593G>C	uc001ebs.2	+	10	1633	c.1276G>C	c.(1276-1278)GCC>CCC	p.A426P	DDX20_uc010owf.1_Missense_Mutation_p.A188P|DDX20_uc001ebt.2_Missense_Mutation_p.A34P	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	426	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATGAGAATTGCCCAGAAATG	0.353													18	37					0	0	0	0	C	112305593	C	C	112305593	3	2	295	1	0	0	0	0	1	0	0	0	4365	1319	46	4	1314	4	DDX20	1	112305593	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	8837568	112305593	136945028	17	54388											
LASS2	29956	broad.mit.edu	37	chr1	150938997	150938997	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atgcgcaaaatgaggtaggcCcagaagatatgcagcagctg	14	6	13	8	1	0	3	0	1	0	2	0	3	0	3	1	2	4	5	1	2	5	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:150938997C>G	uc001evy.2	-	10	1344	c.957G>C	c.(955-957)TGG>TGC	p.W319C	LASS2_uc001evz.2_Missense_Mutation_p.W319C|LASS2_uc009wmh.2_Missense_Mutation_p.W169C	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	319	TLC.|Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGAGGTAGGCCCAGAAGATAT	0.478													17	57					0	0	0	0	G	150938997	G	G	150938997	3	3	295	1	0	0	0	0	1	0	0	0	8679	624	22	4	193	4	LASS2	1	150938997	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	38633404	150938997	98311624	18	54389											
IVL	3713	broad.mit.edu	37	chr1	152883955	152883955	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattcaaccagccctgcccaCaaagggagaagtattgcttc	12	8	8	13	0	1	1	1	0	0	1	2	2	1	1	3	1	4	2	3	1	4	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:152883955C>G	uc001fau.2	+	2	1728	c.1682C>G	c.(1681-1683)ACA>AGA	p.T561R		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	561					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCCTGCCCACAAAGGGAGAA	0.438													16	59					0	0	0	0	G	152883955	G	G	152883955	3	3	295	1	0	0	0	0	1	0	0	0	7968	478	17	4	1684	4	IVL	1	152883955	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	1944958	152883955	96366666	19	54390											
DENND4B	9909	broad.mit.edu	37	chr1	153914360	153914360	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacgcttccaagggtaggCggtgggggcctgagacggag	7	6	18	10	3	1	1	1	1	0	1	2	3	2	2	2	6	0	2	2	6	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:153914360C>G	uc001fdd.1	-	6	1441	c.1040G>C	c.(1039-1041)CGC>CCC	p.R347P		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	347	DENN.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAAGGGTAGGCGGTGGGGGCC	0.632													11	51					0	0	0	0	G	153914360	G	G	153914360	3	3	295	1	0	0	0	0	1	0	0	0	4456	768	27	3	3542	3	DENND4B	1	153914360	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	1030405	153914360	95336261	20	54391											
FCRL3	115352	broad.mit.edu	37	chr1	157659664	157659664	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggatgctgagcaccagcccCgtgattcccgcagcggtaag	9	6	13	13	3	0	2	0	2	0	0	1	3	1	3	4	2	4	4	4	2	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:157659664C>T	uc001frb.2	-	10	2026	c.1734G>A	c.(1732-1734)ACG>ACA	p.T578T	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.T578T|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.T304T|FCRL3_uc001frc.1_Silent_p.T578T	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	578	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					GCACCAGCCCCGTGATTCCCG	0.562													15	40					0	0	0	0	T	157659664	T	T	157659664	2	4	295	1	0	0	0	0	0	0	0	1	5828	639	23	1		1	FCRL3	1	157659664	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	3745304	157659664	91590957	21	54392											
UAP1	6675	broad.mit.edu	37	chr1	162557316	162557316	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttggagtggtttgccgagtgGatggagtttaccaggtggta	7	13	17	4	1	0	0	0	0	0	0	0	4	0	3	2	6	2	3	2	6	2	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:162557316G>A	uc001gce.3	+	6	1215	c.886G>A	c.(886-888)GAT>AAT	p.D296N		NM_003115	NP_003106	Q16222	UAP1_HUMAN	UDP-N-acetylglucosamine pyrophosphorylase 1	296					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			ovary(2)|skin(2)|kidney(1)	5	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TTGCCGAGTGGATGGAGTTTA	0.463													29	99					0	0	0	0	A	162557316	A	A	162557316	3	1	295	1	0	0	0	0	1	0	0	0	16893	1174	41	2	904	2	UAP1	1	162557316	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	4897652	162557316	86693305	22	54393											
NUF2	83540	broad.mit.edu	37	chr1	163317627	163317627	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagactgaagaaaattcgttCaaaagactgatgattgtgaa	18	10	9	4	1	1	7	1	4	0	3	2	7	1	7	0	0	0	1	0	0	7	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:163317627C>T	uc001gcq.1	+	12	1323	c.1023C>T	c.(1021-1023)TTC>TTT	p.F341F	NUF2_uc001gcr.1_Silent_p.F341F|NUF2_uc009wvc.1_Silent_p.F294F	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	341	Interaction with the N-terminus of NDC80.|Potential.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					AAAATTCGTTCAAAAGACTGA	0.338													14	46					0	0	0	0	T	163317627	T	T	163317627	2	4	295	1	0	0	0	0	0	0	0	1	10801	825	29	2		2	NUF2	1	163317627	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	760311	163317627	85932994	23	54394											
PAPPA2	60676	broad.mit.edu	37	chr1	176671756	176671756	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccacagggaggtcacacctGgacagatgtatcagtaccaa	13	7	10	11	0	2	1	2	0	0	1	3	3	3	3	3	3	1	2	3	3	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:176671756G>T	uc001gkz.2	+	9	4414	c.3250G>T	c.(3250-3252)GGA>TGA	p.G1084*	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1084					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GGTCACACCTGGACAGATGTA	0.502													13	35					4.3838e-07	4.94838e-07	1	0	T	176671756	T	T	176671756	4	4	295	1	0	0	0	0	0	1	0	0	11487	1349	47	4	3333	4	PAPPA2	1	176671756	Nonsense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	13354129	176671756	72578865	24	54395											
PAPPA2	60676	broad.mit.edu	37	chr1	176675542	176675542	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agaccttgtgagcggagatgGctgctccaaggtgtgtgagc	8	9	16	8	1	0	4	0	2	0	2	1	5	1	4	2	3	3	2	2	3	1	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:176675542G>C	uc001gkz.2	+	10	4577	c.3413G>C	c.(3412-3414)GGC>GCC	p.G1138A	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1138					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGCGGAGATGGCTGCTCCAAG	0.403													6	33					0	0	0	0	C	176675542	C	C	176675542	3	2	295	1	0	0	0	0	1	0	0	0	11487	1203	42	4	3500	4	PAPPA2	1	176675542	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3786	176675542	72575079	25	54396											
PAPPA2	60676	broad.mit.edu	37	chr1	176709164	176709164	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccactgattatcaatgtgaCccatcaccagaatgtccttt	11	13	5	12	0	2	3	2	2	0	1	4	3	4	3	4	0	0	0	4	0	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:176709164C>G	uc001gkz.2	+	14	5147	c.3983C>G	c.(3982-3984)ACC>AGC	p.T1328S	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1328					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ATCAATGTGACCCATCACCAG	0.463													22	81					0	0	0	0	G	176709164	G	G	176709164	3	3	295	1	0	0	0	0	1	0	0	0	11487	507	18	4	4086	4	PAPPA2	1	176709164	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	33622	176709164	72541457	26	54397											
CEP350	9857	broad.mit.edu	37	chr1	180034395	180034395	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	actgaagaaaatgagaagccGcatggatgaaaagtatttgt	17	9	11	4	1	0	4	0	3	0	2	0	6	0	5	1	1	1	2	1	1	7	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:180034395G>T	uc001gnt.2	+	27	5938	c.5555G>T	c.(5554-5556)CGC>CTC	p.R1852L	CEP350_uc009wxl.2_Missense_Mutation_p.R1851L	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1852						centrosome|nucleus|spindle				ovary(4)	4						ATGAGAAGCCGCATGGATGAA	0.358													7	19					0.000157383	0.000168706	1	0	T	180034395	T	T	180034395	3	4	295	1	0	0	0	0	1	0	0	0	3269	1087	38	3	5657	3	CEP350	1	180034395	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3325231	180034395	69216226	27	54398											
HMCN1	83872	broad.mit.edu	37	chr1	186060049	186060049	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggtgaaacagaaagaatccGgtatgtttaaaaataatctt	17	12	8	4	1	1	3	0	1	1	2	2	3	2	3	1	2	1	2	1	2	8	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:186060049G>T	uc001grq.1	+	64	10116	c.9887G>T	c.(9886-9888)CGA>CTA	p.R3296L		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3296	Ig-like C2-type 31.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAAAGAATCCGGTATGTTTAA	0.353													9	30					3.09899e-07	3.51585e-07	1	0	T	186060049	T	T	186060049	3	4	295	1	0	0	0	0	1	0	0	0	7259	1130	39	3	10141	3	HMCN1	1	186060049	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	6025654	186060049	63190572	28	54399											
HMCN1	83872	broad.mit.edu	37	chr1	186094925	186094925	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcattttagaaaatgttgTggtaagtttaatggacgtga	13	15	10	3	1	1	2	1	1	0	1	1	3	1	3	0	2	0	3	0	2	5	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:186094925T>C	uc001grq.1	+	82	12918	c.12689T>C	c.(12688-12690)GTG>GCG	p.V4230A	HMCN1_uc001grs.1_5'Flank	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4230	Ig-like C2-type 41.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAAAATGTTGTGGTAAGTTTA	0.303													16	21					0	0	0	0	C	186094925	C	C	186094925	3	2	295	1	0	0	0	0	1	0	0	0	7259	1710	59	5	13015	5	HMCN1	1	186094925	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	34876	186094925	63155696	29	54400											
CFH	3075	broad.mit.edu	37	chr1	196697650	196697650	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatccagaagtgaactgctCaagtaagctcttattttgtt	11	14	9	7	0	2	2	1	1	1	1	3	3	3	3	1	1	3	4	1	1	5	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:196697650C>A	uc001gtj.3	+	15	2651	c.2411C>A	c.(2410-2412)TCA>TAA	p.S804*		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	804	Sushi 13.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GTGAACTGCTCAAGTAAGCTC	0.318													16	40					1.33834e-09	1.639e-09	1	0	A	196697650	A	A	196697650	4	1	295	1	0	0	0	0	0	1	0	0	3298	838	29	2	2487	2	CFH	1	196697650	Nonsense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	10602725	196697650	52552971	30	54401											
CFH	3075	broad.mit.edu	37	chr1	196709852	196709852	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acgtacaaatgttttgaaggTtttggaattgatgggcctgc	10	14	12	5	1	0	2	0	2	0	0	0	3	0	3	1	3	2	3	1	3	4	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:196709852T>A	uc001gtj.3	+	18	3126	c.2886T>A	c.(2884-2886)GGT>GGA	p.G962G		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	962	Sushi 16.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GTTTTGAAGGTTTTGGAATTG	0.373													34	65					0	0	0	0	A	196709852	A	A	196709852	2	1	295	1	0	0	0	0	0	0	0	1	3298	1712	60	5		5	CFH	1	196709852	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	12202	196709852	52540769	31	54402											
MYBPH	4608	broad.mit.edu	37	chr1	203140617	203140617	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccgagcgaatgaagaggatGgagtcctggtccccggtgcg	8	6	17	10	4	0	2	0	1	0	1	2	6	2	4	4	4	2	0	4	4	2	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:203140617G>C	uc001gzh.1	-	5	746	c.687C>G	c.(685-687)TCC>TCG	p.S229S	FMOD_uc010pqi.1_Intron	NM_004997	NP_004988	Q13203	MYBPH_HUMAN	myosin binding protein H	229	Ig-like C2-type 1.				cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle				0			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		TGAAGAGGATGGAGTCCTGGT	0.652													14	41					0	0	0	0	C	203140617	C	C	203140617	2	2	295	1	0	0	0	0	0	0	0	1	10067	1335	47	4		4	MYBPH	1	203140617	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	6430765	203140617	46110004	32	54403											
PROX1	5629	broad.mit.edu	37	chr1	214170722	214170722	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgaagacagcatgcgctcgGagatcctggatgccagggcc	9	6	14	12	2	0	3	0	1	0	2	2	5	1	4	3	3	3	2	3	3	1	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:214170722G>A	uc001hkh.2	+	2	1116	c.844G>A	c.(844-846)GAG>AAG	p.E282K	PROX1_uc001hkg.1_Missense_Mutation_p.E282K	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	282					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CATGCGCTCGGAGATCCTGGA	0.517													21	63					0	0	0	0	A	214170722	A	A	214170722	3	1	295	1	0	0	0	0	1	0	0	0	12622	1175	41	2	846	2	PROX1	1	214170722	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	11030105	214170722	35079899	33	54404											
SLC35F3	148641	broad.mit.edu	37	chr1	234444872	234444872	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgtcgattttttggagacAatggcttgactttgaaggtg	8	15	13	5	1	0	3	0	2	0	1	1	5	0	3	0	3	0	2	0	3	2	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:234444872A>T	uc001hwa.1	+	3	655	c.427A>T	c.(427-429)AAT>TAT	p.N143Y	SLC35F3_uc001hvy.1_Missense_Mutation_p.N212Y	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	143					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TTTTGGAGACAATGGCTTGAC	0.378													26	91					0	0	0	0	T	234444872	T	T	234444872	3	4	295	1	0	0	0	0	1	0	0	0	14654	130	5	5	648	5	SLC35F3	1	234444872	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	20274150	234444872	14805749	34	54405											
SLC35F3	148641	broad.mit.edu	37	chr1	234444975	234444975	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcaataaagaaaataaacaCtacggatgtctccgtgttgt	15	11	8	7	2	1	1	0	0	1	1	2	2	1	2	1	1	3	2	1	1	8	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:234444975C>A	uc001hwa.1	+	3	758	c.530C>A	c.(529-531)ACT>AAT	p.T177N	SLC35F3_uc001hvy.1_Missense_Mutation_p.T246N	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	177					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			AAAATAAACACTACGGATGTC	0.438													30	90					3.73148e-12	4.76563e-12	1	0	A	234444975	A	A	234444975	3	1	295	1	0	0	0	0	1	0	0	0	14654	565	20	4	751	4	SLC35F3	1	234444975	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	103	234444975	14805646	35	54406											
RYR2	6262	broad.mit.edu	37	chr1	237923109	237923109	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctcaaggagaaaaaggatGtgggcttctttcagagcctg	12	9	12	8	0	3	2	2	0	1	2	3	4	3	3	2	3	1	1	2	3	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:237923109G>T	uc001hyl.1	+	83	11479	c.11359G>T	c.(11359-11361)GTG>TTG	p.V3787L	RYR2_uc010pya.1_Missense_Mutation_p.V202L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3787					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAAAAAGGATGTGGGCTTCTT	0.413													17	62					4.96729e-08	5.75228e-08	1	0	T	237923109	T	T	237923109	3	4	295	1	0	0	0	0	1	0	0	0	13834	1377	48	4	11689	4	RYR2	1	237923109	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3478134	237923109	11327512	36	54407											
FMN2	56776	broad.mit.edu	37	chr1	240351556	240351556	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caaaaacgctcagatgctgtCcagaaggtaagatgatctta	15	9	9	8	1	2	4	1	1	1	3	3	4	3	4	1	1	2	3	1	1	5	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:240351556C>G	uc010pyd.1	+	4	2205	c.1980C>G	c.(1978-1980)GTC>GTG	p.V660V	FMN2_uc010pye.1_Silent_p.V664V	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	660					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGATGCTGTCCAGAAGGTAA	0.408													13	66					0	0	0	0	G	240351556	G	G	240351556	2	3	295	1	0	0	0	0	0	0	0	1	5982	842	30	2		2	FMN2	1	240351556	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2428447	240351556	8899065	37	54408											
RGS7	6000	broad.mit.edu	37	chr1	240976951	240976951	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cccagaaagtggtgtcatcgGacagccatgggttagaaggg	11	7	15	8	1	1	2	1	0	0	2	2	3	1	3	2	4	1	1	2	4	3	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:240976951G>T	uc001hyv.2	-	13	1253	c.923C>A	c.(922-924)TCC>TAC	p.S308Y	RGS7_uc010pyh.1_Missense_Mutation_p.S282Y|RGS7_uc010pyj.1_Missense_Mutation_p.S224Y|RGS7_uc001hyu.2_Missense_Mutation_p.S308Y|RGS7_uc009xgn.1_Missense_Mutation_p.S255Y|RGS7_uc001hyw.2_Missense_Mutation_p.S308Y|RGS7_uc001hyt.2_Missense_Mutation_p.S140Y	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	308	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GGTGTCATCGGACAGCCATGG	0.443													5	22					1.6384e-10	2.04001e-10	1	0	T	240976951	T	T	240976951	3	4	295	1	0	0	0	0	1	0	0	0	13375	1174	41	2	564	2	RGS7	1	240976951	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	625395	240976951	8273670	38	54409											
OR13G1	441933	broad.mit.edu	37	chr1	247835845	247835845	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggtcaatggtgtttggccCacagaaagtcaacctcatga	11	10	11	9	0	3	2	3	1	0	1	3	2	3	2	2	3	1	1	2	3	3	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:247835845C>A	uc001idi.1	-	1	499	c.499G>T	c.(499-501)GGG>TGG	p.G167W		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GTGTTTGGCCCACAGAAAGTC	0.483													15	38					0.000308642	0.000327703	1	0	A	247835845	A	A	247835845	3	1	295	1	0	0	0	0	1	0	0	0	10996	594	21	4	428	4	OR13G1	1	247835845	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	6858894	247835845	1414776	39	54410											
OR2T6	254879	broad.mit.edu	37	chr1	248551061	248551061	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	catgatcttcctgattaacaTagaccctcatctccacaccc	11	11	3	16	0	3	3	1	2	2	1	5	3	4	3	4	0	1	0	4	0	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:248551061T>C	uc001iei.1	+	1	152	c.152T>C	c.(151-153)ATA>ACA	p.I51T		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGATTAACATAGACCCTCAT	0.458													9	31					0	0	0	0	C	248551061	C	C	248551061	3	2	295	1	0	0	0	0	1	0	0	0	11083	1406	49	5	154	5	OR2T6	1	248551061	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	715216	248551061	699560	40	54411											
OR2G6	391211	broad.mit.edu	37	chr1	248685492	248685492	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatattttctgtgaggtgcCagtgctcatcaaactggcct	8	14	9	10	0	4	1	3	1	1	0	4	1	4	1	2	2	3	1	2	2	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:248685492C>T	uc001ien.1	+	1	545	c.545C>T	c.(544-546)CCA>CTA	p.P182L		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTGAGGTGCCAGTGCTCATC	0.512													12	45					0	0	0	0	T	248685492	T	T	248685492	3	4	295	1	0	0	0	0	1	0	0	0	11054	594	21	4	547	4	OR2G6	1	248685492	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	134431	248685492	565129	41	54412											
APOB	338	broad.mit.edu	37	chr2	21234732	21234732	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccaagctctgcattcagctCattctccagcaccaggagac	10	8	8	15	0	4	1	2	0	2	1	5	2	4	1	3	1	4	4	3	1	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:21234732C>A	uc002red.2	-	26	5136	c.5008G>T	c.(5008-5010)GAG>TAG	p.E1670*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1670				E -> D (in Ref. 8; AAA51752).	cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCATTCAGCTCATTCTCCAGC	0.473													10	44					0.000442599	0.00046882	1	0	A	21234732	A	A	21234732	4	1	295	1	0	0	0	0	0	1	0	0	785	835	29	2	8699	2	APOB	2	21234732	Nonsense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08		21234732	221964641	42	54413											
SLC8A1	6546	broad.mit.edu	37	chr2	40656161	40656161	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggccacagtaccacagttCtccagacactgatatgtccc	11	8	8	14	0	1	2	0	1	1	1	3	2	2	2	4	1	1	2	4	1	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:40656161C>G	uc002rrx.2	-	1	1284	c.1260G>C	c.(1258-1260)GAG>GAC	p.E420D	SLC8A1_uc002rry.2_Missense_Mutation_p.E420D|SLC8A1_uc002rrz.2_Missense_Mutation_p.E420D|SLC8A1_uc002rsa.2_Missense_Mutation_p.E420D|SLC8A1_uc002rsd.3_Missense_Mutation_p.E420D|SLC8A1_uc002rsb.1_Missense_Mutation_p.E420D|SLC8A1_uc010fan.1_Missense_Mutation_p.E420D|SLC8A1_uc002rsc.1_Missense_Mutation_p.E420D	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	420	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TACCACAGTTCTCCAGACACT	0.463													19	36					0	0	0	0	G	40656161	G	G	40656161	3	3	295	1	0	0	0	0	1	0	0	0	14770	912	32	2	1809	2	SLC8A1	2	40656161	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	19421429	40656161	202543212	43	54414											
EML4	27436	broad.mit.edu	37	chr2	42472706	42472706	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcctgtcagctcttgagtcAcgagttcagcaacaagaaga	12	8	10	11	2	4	3	3	1	1	2	4	4	4	3	1	0	3	3	1	0	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:42472706A>G	uc002rsi.2	+	2	349	c.87A>G	c.(85-87)TCA>TCG	p.S29S	EML4_uc002rsh.3_Silent_p.S29S|EML4_uc010fap.2_Silent_p.S29S	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	29					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						CTCTTGAGTCACGAGTTCAGC	0.383			T	ALK	NSCLC								12	35					0	0	0	0	G	42472706	G	G	42472706	2	3	295	1	0	0	0	0	0	0	0	1	5123	146	6	5		5	EML4	2	42472706	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	1816545	42472706	200726667	44	54415											
CCDC85A	114800	broad.mit.edu	37	chr2	56420144	56420144	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctgtggaaccccagatcGccccaaagcactcaaaggac	13	4	9	15	1	1	1	1	0	0	1	2	3	1	3	5	2	3	1	5	2	3	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:56420144G>T	uc002rzn.2	+	2	1311	c.809G>T	c.(808-810)CGC>CTC	p.R270L		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	270	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACCCCAGATCGCCCCAAAGCA	0.652													17	56					1.62849e-17	2.25367e-17	1	0	T	56420144	T	T	56420144	3	4	295	1	0	0	0	0	1	0	0	0	2872	1087	38	3	815	3	CCDC85A	2	56420144	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	13947438	56420144	186779229	45	54416											
AFF3	3899	broad.mit.edu	37	chr2	100210155	100210155	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggatttggggacgatcctGcttagcccccgcgtgcggcg	4	10	15	12	5	0	0	0	0	0	0	1	3	1	2	3	4	3	1	3	4	1	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:100210155G>T	uc002tag.2	-	14	2204	c.1968C>A	c.(1966-1968)AGC>AGA	p.S656R	AFF3_uc002taf.2_Missense_Mutation_p.S681R|AFF3_uc010fiq.1_Missense_Mutation_p.S656R|AFF3_uc010yvr.1_Missense_Mutation_p.S809R|AFF3_uc002tah.1_Missense_Mutation_p.S681R	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	656					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GGACGATCCTGCTTAGCCCCC	0.617													40	106					4.40578e-31	6.45699e-31	1	0	T	100210155	T	T	100210155	3	4	295	1	0	0	0	0	1	0	0	0	358	1310	46	4	1756	4	AFF3	2	100210155	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	43790011	100210155	142989218	46	54417											
CCDC138	165055	broad.mit.edu	37	chr2	109473416	109473416	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatagtttgctccagatgacGgtggaatctagtaagttttt	10	15	11	5	1	1	2	0	1	1	1	2	4	2	3	1	2	1	4	1	2	4	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:109473416G>T	uc002ten.1	+	13	1743	c.1683G>T	c.(1681-1683)ACG>ACT	p.T561T	CCDC138_uc002teo.1_Silent_p.T561T|CCDC138_uc002tep.1_Silent_p.T245T|CCDC138_uc010fjm.1_Silent_p.T245T	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	561											0						TCCAGATGACGGTGGAATCTA	0.343													16	41					2.32078e-09	2.82668e-09	1	0	T	109473416	T	T	109473416	2	4	295	1	0	0	0	0	0	0	0	1	2784	1103	39	3		3	CCDC138	2	109473416	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	9263261	109473416	133725957	47	54418											
GPR17	2840	broad.mit.edu	37	chr2	128409254	128409254	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgcaacttgctctgtggcaaAaggctcaagggcccgccccc	8	7	11	15	1	2	0	1	0	1	0	2	0	2	0	3	3	3	4	3	3	4	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:128409254A>G	uc010yzn.1	+	4	1640	c.1029A>G	c.(1027-1029)AAA>AAG	p.K343K	LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Silent_p.K343K|GPR17_uc010yzo.1_Silent_p.K315K|GPR17_uc002tpd.2_Silent_p.K315K	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	343	Cytoplasmic (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		TCTGTGGCAAAAGGCTCAAGG	0.632													26	81					0	0	0	0	G	128409254	G	G	128409254	2	3	295	1	0	0	0	0	0	0	0	1	6705	11	1	5		5	GPR17	2	128409254	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	18935838	128409254	114790119	48	54419											
THSD7B	80731	broad.mit.edu	37	chr2	138169330	138169330	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagggagcctcaccgaggActgcgggtacaagcagacag	13	3	15	10	2	1	2	1	0	0	2	1	5	1	4	2	3	4	2	2	3	3	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:138169330A>C	uc002tva.1	+	13	2754	c.2754A>C	c.(2752-2754)GGA>GGC	p.G918G	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.G808G	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTCACCGAGGACTGCGGGTAC	0.483													19	61					0	0	0	0	C	138169330	C	C	138169330	2	2	295	1	0	0	0	0	0	0	0	1	15946	262	10	5		5	THSD7B	2	138169330	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	9760076	138169330	105030043	49	54420											
EPC2	26122	broad.mit.edu	37	chr2	149447814	149447814	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagcgagcaatttcagcacAgcaagtgtttagagaaaaaa	18	7	9	7	1	1	1	1	0	0	1	1	3	1	1	0	0	4	4	0	0	6	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:149447814A>G	uc010zbt.1	+	2	212	c.185A>G	c.(184-186)CAG>CGG	p.Q62R		NM_015630	NP_056445	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2	62					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)		ATTTCAGCACAGCAAGTGTTT	0.333													13	25					0	0	0	0	G	149447814	G	G	149447814	3	3	295	1	0	0	0	0	1	0	0	0	5185	188	7	5	191	5	EPC2	2	149447814	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	11278484	149447814	93751559	50	54421											
CYTIP	9595	broad.mit.edu	37	chr2	158272443	158272443	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcatctgtactcgtctgccGactgaaggcacccctgctgg	7	10	10	14	2	3	1	1	1	2	0	4	2	3	1	3	2	3	3	3	2	2	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:158272443G>T	uc002tzj.1	-	8	898	c.826C>A	c.(826-828)CGG>AGG	p.R276R	CYTIP_uc010zcl.1_Silent_p.R170R	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	276	Ser-rich.				regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						CTCGTCTGCCGACTGAAGGCA	0.537													16	43					9.16793e-09	1.09282e-08	1	0	T	158272443	T	T	158272443	2	4	295	1	0	0	0	0	0	0	0	1	4224	1057	37	3		3	CYTIP	2	158272443	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	8824629	158272443	84926930	51	54422											
PLA2R1	22925	broad.mit.edu	37	chr2	160833232	160833232	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggaatcttgggtttcacatCtgcaaagtgaaagcaaatca	14	10	9	8	1	4	1	2	1	2	0	4	2	4	2	0	2	2	3	0	2	4	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:160833232C>T	uc002ube.1	-	16	2609	c.2402_splice	c.e16-1	p.D801_splice	PLA2R1_uc010zcp.1_Splice_Site_p.D801_splice|PLA2R1_uc002ubf.2_Splice_Site_p.D801_splice	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor						endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GGTTTCACATCTGCAAAGTGA	0.358													6	26					0	0	0	0	T	160833232	T	T	160833232	5	4	295	1	0	0	0	0	0	0	1	0	12065	927	32	2	2058	2	PLA2R1	2	160833232	Splice_Site	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2560789	160833232	82366141	52	54423											
FAP	2191	broad.mit.edu	37	chr2	163027570	163027570	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggacaggccggataagccGtggttctggtcagagtacca	9	8	15	9	2	2	1	1	0	1	1	2	3	2	3	3	5	2	2	3	5	2	3	rs138589105	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:163027570G>A	uc002ucd.2	-	26	2410	c.2202C>T	c.(2200-2202)CAC>CAT	p.H734H	FAP_uc010fpc.2_Silent_p.H283H|FAP_uc010zct.1_Silent_p.H709H|FAP_uc010fpd.2_Silent_p.H213H	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	734	Extracellular (Potential).	Charge relay system.			endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						CGGATAAGCCGTGGTTCTGGT	0.438													28	66					0	0	0	0	A	163027570	A	A	163027570	2	1	295	1	0	0	0	0	0	0	0	1	5705	1136	40	1		1	FAP	2	163027570	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2194338	163027570	80171803	53	54424											
SCN2A	6326	broad.mit.edu	37	chr2	166245537	166245537	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaagatcaccctggaagcTcagttaaaggagactgtggg	14	7	12	8	0	2	2	2	0	0	2	2	4	2	3	1	3	1	2	1	3	4	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:166245537T>A	uc002udc.2	+	27	5511	c.5221T>A	c.(5221-5223)TCA>ACA	p.S1741T	SCN2A_uc002udd.2_Missense_Mutation_p.S1741T|SCN2A_uc002ude.2_Missense_Mutation_p.S1741T	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1741	IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	CCCTGGAAGCTCAGTTAAAGG	0.458													47	135					0	0	0	0	A	166245537	A	A	166245537	3	1	295	1	0	0	0	0	1	0	0	0	13981	1551	54	5	5419	5	SCN2A	2	166245537	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	3217967	166245537	76953836	54	54425											
LRP2	4036	broad.mit.edu	37	chr2	169999284	169999284	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcagaggtggctgcagatCtgtttgcaaaggttgggcac	9	9	16	7	0	1	2	0	0	1	2	1	2	1	2	0	5	2	7	0	5	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:169999284C>A	uc002ues.2	-	71	13221	c.13008G>T	c.(13006-13008)CAG>CAT	p.Q4336H		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4336	EGF-like 16.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGCTGCAGATCTGTTTGCAAA	0.537													14	54					6.31663e-08	7.29595e-08	1	0	A	169999284	A	A	169999284	3	1	295	1	0	0	0	0	1	0	0	0	9006	912	32	2	995	2	LRP2	2	169999284	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	3753747	169999284	73200089	55	54426											
HOXD10	3236	broad.mit.edu	37	chr2	176981826	176981826	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cagatccgaacagatcttgtCgaatagagcaacctgttaca	14	9	8	10	2	1	3	0	0	1	3	3	5	2	3	2	0	4	2	2	0	5	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:176981826C>G	uc002ukj.2	+	1	335	c.265C>G	c.(265-267)CGA>GGA	p.R89G		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	89						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		CAGATCTTGTCGAATAGAGCA	0.433													24	71					0	0	0	0	G	176981826	G	G	176981826	3	3	295	1	0	0	0	0	1	0	0	0	7358	876	31	3	267	3	HOXD10	2	176981826	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	6982542	176981826	66217547	56	54427											
TTN	7273	broad.mit.edu	37	chr2	179588653	179588653	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gccacgcatgtgtaattgccCatatctgaggaatccagaga	12	9	10	10	1	1	2	0	1	1	1	2	4	2	3	3	1	1	2	3	1	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:179588653C>T	uc010zfg.1	-	70	17825	c.17601G>A	c.(17599-17601)ATG>ATA	p.M5867I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.M2528I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6794							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAATTGCCCATATCTGAGG	0.423													11	38					0	0	0	0	T	179588653	T	T	179588653	3	4	295	1	0	0	0	0	1	0	0	0	16803	594	21	4	83356	4	TTN	2	179588653	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2606827	179588653	63610720	57	54428											
ZNF804A	91752	broad.mit.edu	37	chr2	185800594	185800594	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atttcccaacgagttgttgtGgattcagttaataaccagca	12	13	8	8	1	1	0	1	0	0	0	2	2	2	1	2	1	3	4	2	1	3	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:185800594G>T	uc002uph.2	+	4	1065	c.471G>T	c.(469-471)GTG>GTT	p.V157V		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	157						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAGTTGTTGTGGATTCAGTTA	0.383													7	36					2.7689e-08	3.23158e-08	1	0	T	185800594	T	T	185800594	2	4	295	1	0	0	0	0	0	0	0	1	18237	1335	47	4		4	ZNF804A	2	185800594	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	6211941	185800594	57398779	58	54429											
ZNF804A	91752	broad.mit.edu	37	chr2	185803491	185803491	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgcagctgcaggaacctttaAagtgcttcagccacaccaac	12	7	8	14	1	1	0	1	0	0	0	1	1	1	1	3	1	6	4	3	1	4	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:185803491A>C	uc002uph.2	+	4	3962	c.3368A>C	c.(3367-3369)AAA>ACA	p.K1123T		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1123						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						gGAACCTTTAAAGTGCTTCAG	0.343													12	58					0	0	0	0	C	185803491	C	C	185803491	3	2	295	1	0	0	0	0	1	0	0	0	18237	14	1	5	3382	5	ZNF804A	2	185803491	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	2897	185803491	57395882	59	54430											
SLC39A10	57181	broad.mit.edu	37	chr2	196578254	196578254	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caatacaccagattctgactGgcttcaactcaagcctcttg	11	11	6	13	0	4	2	2	1	2	1	4	2	4	2	2	1	3	1	2	1	4	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:196578254G>A	uc002utg.3	+	6	1887	c.1673G>A	c.(1672-1674)TGG>TAG	p.W558*	SLC39A10_uc002uth.3_Nonsense_Mutation_p.W558*|SLC39A10_uc010zgp.1_Nonsense_Mutation_p.W108*	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	558					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			GATTCTGACTGGCTTCAACTC	0.323													13	22					0	0	0	0	A	196578254	A	A	196578254	4	1	295	1	0	0	0	0	0	1	0	0	14677	1357	47	4	1691	4	SLC39A10	2	196578254	Nonsense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	10774763	196578254	46621119	60	54431											
DNAH7	56171	broad.mit.edu	37	chr2	196765106	196765106	+	Missense_Mutation	SNP	G	C	C																															ctgaacacaagcgatacgtaGccacaatttttacagacagt																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:196765106G>C	uc002utj.3	-	28	4549	c.4448C>G	c.(4447-4449)GCT>GGT	p.A1483G		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1483	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GCGATACGTAGCCACAATTTT	0.458													32	123					0	0	0	0	C	196765106	C	C	196765106	3	2	295	1	0	0	0	0	1	0	0	0	4628	971	34	4	7778	4	DNAH7	2	196765106	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	186852	196765106	46434267	61	54432	126	2									
DNAH7	56171	broad.mit.edu	37	chr2	196765116	196765116	+	Missense_Mutation	SNP	T	C	C																															gcgatacgtagccacaatttTtacagacagtggtcgagcag																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:196765116T>C	uc002utj.3	-	28	4539	c.4438A>G	c.(4438-4440)AAA>GAA	p.K1480E		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1480	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GCCACAATTTTTACAGACAGT	0.463													37	122					0	0	0	0	C	196765116	C	C	196765116	3	2	295	1	0	0	0	0	1	0	0	0	4628	1850	64	5	7788	5	DNAH7	2	196765116	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	10	196765116	46434257	62	54433	126	2									
HECW2	57520	broad.mit.edu	37	chr2	197183378	197183378	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctctcggcagcagctgcagCtccctccaggctccccctcc	4	7	9	21	1	1	0	0	0	1	0	6	0	5	0	5	2	4	7	5	2	0	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:197183378C>T	uc002utm.1	-	9	2419	c.2236G>A	c.(2236-2238)GCT>ACT	p.A746T	HECW2_uc002utl.1_Missense_Mutation_p.A390T	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	746	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GCAGCTGCAGCTCCCTCCAGG	0.682													13	41					0	0	0	0	T	197183378	T	T	197183378	3	4	295	1	0	0	0	0	1	0	0	0	7082	797	28	4	2566	4	HECW2	2	197183378	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	418262	197183378	46015995	63	54434											
MAP2	4133	broad.mit.edu	37	chr2	210559334	210559334	+	Frame_Shift_Del	DEL	G	-	-																															ctgaaatgctagatctggcaGgcacaaggtcaagattggct																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:210559334delG	uc002vde.1	+	7	2688	c.2440delG	c.(2440-2442)GGCfs	p.G814fs	MAP2_uc002vdc.1_Frame_Shift_Del_p.G814fs|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Frame_Shift_Del_p.G810fs	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	814					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGATCTGGCAGGCACAAGGTC	0.473													---	---	---								-	210559334	-	-	210559334	7	5	295	1	0	1	0	1	0	0	0	0	9288	1000	35	0	2454	0	MAP2	2	210559334	Frame_Shift_Del	DEL	G	TCGA-F7-7848-01A-11D-2129-08	13375956	210559334	32640039	64	54435											
MOGAT1	116255	broad.mit.edu	37	chr2	223554124	223554124	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtttcctggctttacttcAtatcttcacgtgctgccact	5	17	6	13	1	3	0	2	0	1	0	4	0	4	0	2	1	3	3	2	1	2	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:223554124A>T	uc010fws.1	+	3	462	c.414A>T	c.(412-414)TCA>TCT	p.S138S	MOGAT1_uc010fwt.1_Silent_p.S98S	NM_058165	NP_477513	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	138	Helical; (Potential).				glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)	1		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)		GCTTTACTTCATATCTTCACG	0.428													17	73					0	0	0	0	T	223554124	T	T	223554124	2	4	295	1	0	0	0	0	0	0	0	1	9747	204	8	5		5	MOGAT1	2	223554124	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	12994790	223554124	19645249	65	54436											
COL4A3	1285	broad.mit.edu	37	chr2	228169782	228169782	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tggagaaaaaggcaacaaagGttctaaaggagagccaggta	18	5	13	5	0	1	2	0	0	1	2	1	4	1	2	1	5	2	3	1	5	7	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:228169782G>A	uc002vom.1	+	47	4397	c.4235G>A	c.(4234-4236)GGT>GAT	p.G1412D	COL4A3_uc002von.1_Missense_Mutation_p.G1412D|COL4A3_uc002voo.1_Missense_Mutation_p.G1412D|COL4A3_uc002vop.1_Missense_Mutation_p.G1412D|uc002voq.1_Intron|uc002vor.1_Intron|COL4A3_uc010fxf.1_5'Flank	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1412	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCAACAAAGGTTCTAAAGGA	0.488													7	17					0	0	0	0	A	228169782	A	A	228169782	3	1	295	1	0	0	0	0	1	0	0	0	3706	1261	44	4	4421	4	COL4A3	2	228169782	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	4615658	228169782	15029591	66	54437											
SLC19A3	80704	broad.mit.edu	37	chr2	228563763	228563763	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcacagcctggtgcttcaCcttcgtgagtttcctctaat	6	15	7	13	1	3	1	2	1	1	0	5	1	4	1	3	1	2	2	3	1	1	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:228563763C>A	uc002vpi.2	-	3	757	c.668G>T	c.(667-669)GGT>GTT	p.G223V	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.G219V	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	223	Cytoplasmic (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	TGGTGCTTCACCTTCGTGAGT	0.448													15	40					0.000308642	0.000327703	1	0	A	228563763	A	A	228563763	3	1	295	1	0	0	0	0	1	0	0	0	14495	507	18	4	838	4	SLC19A3	2	228563763	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	393981	228563763	14635610	67	54438											
CCL20	6364	broad.mit.edu	37	chr2	228681044	228681044	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcacacaaagaaaaagttGtctgtgtgcgcaaatccaaa	16	10	7	8	1	2	1	1	0	1	1	3	1	3	1	1	0	1	2	1	0	5	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:228681044G>T	uc002vpl.2	+	3	283	c.213G>T	c.(211-213)TTG>TTT	p.L71F	CCL20_uc002vpm.2_Missense_Mutation_p.L70F	NM_004591	NP_004582	P78556	CCL20_HUMAN	chemokine (C-C motif) ligand 20 isoform 1	71					cell-cell signaling|chemotaxis|defense response to bacterium|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity				0		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;7.3e-11)|all cancers(144;4.13e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		AGAAAAAGTTGTCTGTGTGCG	0.338													18	31					3.5997e-14	4.77468e-14	1	0	T	228681044	T	T	228681044	3	4	295	1	0	0	0	0	1	0	0	0	2905	1368	48	4	223	4	CCL20	2	228681044	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	117281	228681044	14518329	68	54439											
SPHKAP	80309	broad.mit.edu	37	chr2	228855881	228855881	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgggggctggctgttcccgtAggcggtccagatgcaggtgc	4	9	18	10	2	0	1	0	0	0	1	2	1	2	1	2	6	2	5	2	6	1	2	rs137978320	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:228855881A>T	uc002vpq.2	-	11	4841	c.4794T>A	c.(4792-4794)CCT>CCA	p.P1598P	SPHKAP_uc002vpp.2_Silent_p.P1569P|SPHKAP_uc010zlx.1_Intron	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1598						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTGTTCCCGTAGGCGGTCCAG	0.562													10	40					0	0	0	0	T	228855881	T	T	228855881	2	4	295	1	0	0	0	0	0	0	0	1	15114	407	15	5		5	SPHKAP	2	228855881	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	174837	228855881	14343492	69	54440											
ALPPL2	251	broad.mit.edu	37	chr2	233273006	233273006	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtggaggccgaaagtacatGtttcccatggggaccccaga	10	7	14	10	1	0	1	0	0	0	1	1	4	1	3	4	5	1	2	4	5	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:233273006G>T	uc002vss.3	+	6	731	c.678G>T	c.(676-678)ATG>ATT	p.M226I		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	226					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GAAAGTACATGTTTCCCATGG	0.617													21	98					2.21704e-12	2.84774e-12	1	0	T	233273006	T	T	233273006	3	4	295	1	0	0	0	0	1	0	0	0	549	1377	48	4	700	4	ALPPL2	2	233273006	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	4417125	233273006	9926367	70	54441											
CHL1	10752	broad.mit.edu	37	chr3	432410	432410	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atacagctccagtgatccatGgggtggacgttataaacagt	12	10	11	8	1	0	1	0	1	0	0	2	2	2	2	2	3	3	2	2	3	4	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:432410G>T	uc003bou.2	+	20	2720	c.2449G>T	c.(2449-2451)GGG>TGG	p.G817W	CHL1_uc003bot.2_Missense_Mutation_p.G833W|CHL1_uc003bow.1_Missense_Mutation_p.G817W|CHL1_uc011asi.1_Missense_Mutation_p.G833W	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	817	Fibronectin type-III 3.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGTGATCCATGGGGTGGACGT	0.363													7	33					1.76689e-08	2.07842e-08	1	0	T	432410	T	T	432410	3	4	295	1	0	0	0	0	1	0	0	0	3364	1348	47	4	2571	4	CHL1	3	432410	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08		432410	197590020	71	54442											
GRM7	2917	broad.mit.edu	37	chr3	7494447	7494447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgcccagagatggagcaagCtggaggcaagaagttgctga	12	6	15	8	0	0	3	0	1	0	2	0	6	0	5	1	3	4	5	1	3	3	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:7494447C>T	uc003bqm.2	+	6	1602	c.1328C>T	c.(1327-1329)GCT>GTT	p.A443V	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.A443V|GRM7_uc003bql.2_Missense_Mutation_p.A443V|GRM7_uc003bqn.1_Missense_Mutation_p.A26V|GRM7_uc010hch.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	443	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	ATGGAGCAAGCTGGAGGCAAG	0.463													3	11					0	0	0	0	T	7494447	T	T	7494447	3	4	295	1	0	0	0	0	1	0	0	0	6841	797	28	4	1350	4	GRM7	3	7494447	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	7062037	7494447	190527983	72	54443											
PLCL2	23228	broad.mit.edu	37	chr3	17051331	17051331	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttatcataggtactttttaCtggatgctgacatgcagagc	10	15	9	7	0	1	2	1	1	0	1	1	3	1	3	0	2	5	3	0	2	4	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:17051331C>T	uc011awc.1	+	5	574	c.469C>T	c.(469-471)CTG>TTG	p.L157L	PLCL2_uc010het.1_Silent_p.L39L|PLCL2_uc011awd.1_Silent_p.L39L	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	165	PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GTACTTTTTACTGGATGCTGA	0.403													4	30					0	0	0	0	T	17051331	T	T	17051331	2	4	295	1	0	0	0	0	0	0	0	1	12095	564	20	4		4	PLCL2	3	17051331	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	9556884	17051331	180971099	73	54444											
STAC	6769	broad.mit.edu	37	chr3	36545898	36545898	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttcagtgtttacatatccAgaaaatggcactgatgattt	12	14	7	8	0	1	3	1	2	0	1	2	3	2	3	2	1	1	2	2	1	4	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:36545898A>T	uc003cgh.1	+	7	819	c.780A>T	c.(778-780)CCA>CCT	p.P260P	STAC_uc010hgd.1_RNA|STAC_uc011aya.1_Silent_p.P199P	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	260					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						TTACATATCCAGAAAATGGCA	0.373													3	22					0	0	0	0	T	36545898	T	T	36545898	2	4	295	1	0	0	0	0	0	0	0	1	15305	175	7	5		5	STAC	3	36545898	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	19494567	36545898	161476532	74	54445											
LTF	4057	broad.mit.edu	37	chr3	46479621	46479621	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatttctcccaaatttagcCtgcgacaaaagggcagacag	13	8	8	12	1	1	1	0	0	1	1	2	2	1	1	3	1	2	1	3	1	4	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:46479621C>A	uc003cpq.2	-	16	1947	c.1909_splice	c.e16-1	p.A637_splice	LTF_uc003fzr.2_Splice_Site_p.A593_splice|LTF_uc010hjh.2_Splice_Site_p.A635_splice|LTF_uc003cpr.2_Splice_Site_p.A624_splice	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor						cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity	p.?(1)		central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	CAAATTTAGCCTGCGACAAAA	0.448													15	95					1.3612e-06	1.52114e-06	1	0	A	46479621	A	A	46479621	5	1	295	1	0	0	0	0	0	0	1	0	9129	695	24	4	232	4	LTF	3	46479621	Splice_Site	SNP	C	TCGA-F7-7848-01A-11D-2129-08	9933723	46479621	151542809	75	54446											
PFKFB4	5210	broad.mit.edu	37	chr3	48563099	48563099	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaggtcatttcctcacagaCgccctagggagataccacag	11	8	10	12	1	2	2	2	0	0	2	3	3	3	2	3	2	1	1	3	2	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:48563099C>T	uc003ctv.2	-	10	1008	c.991G>A	c.(991-993)GTC>ATC	p.V331I	PFKFB4_uc003ctw.2_Missense_Mutation_p.V140I|PFKFB4_uc010hkc.2_Intron|PFKFB4_uc003ctx.2_Missense_Mutation_p.V288I|PFKFB4_uc010hkb.2_Missense_Mutation_p.V324I|PFKFB4_uc011bbm.1_Missense_Mutation_p.V320I|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	331	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		TCCTCACAGACGCCCTAGGGA	0.542													5	16					0	0	0	0	T	48563099	T	T	48563099	3	4	295	1	0	0	0	0	1	0	0	0	11818	536	19	1	438	1	PFKFB4	3	48563099	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2083478	48563099	149459331	76	54447											
QARS	5859	broad.mit.edu	37	chr3	49142161	49142161	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgacagggagtctagagcCgccattgcagagacaccgga	12	4	14	11	3	1	2	0	0	1	2	1	6	1	4	3	2	3	1	3	2	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:49142161C>G	uc003cvx.2	-	1	11	c.6G>C	c.(4-6)GCG>GCC	p.A2A	QARS_uc011bcd.1_5'Flank|QARS_uc003cvy.2_5'UTR|QARS_uc011bce.1_Silent_p.A2A|QARS_uc011bcf.1_Silent_p.A2A	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	2					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AGTCTAGAGCCGCCATTGCAG	0.612													8	45					0	0	0	0	G	49142161	G	G	49142161	2	3	295	1	0	0	0	0	0	0	0	1	12936	639	23	3		3	QARS	3	49142161	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	579062	49142161	148880269	77	54448											
ERC2	26059	broad.mit.edu	37	chr3	56468959	56468959	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgttcttcggtggcccaaaCgaggagaccttggcaaacga	10	9	12	10	3	1	1	0	0	1	1	2	4	1	1	2	4	2	2	2	4	2	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:56468959C>T	uc003dhr.1	-	2	333	c.77G>A	c.(76-78)CGT>CAT	p.R26H		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	26						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTGGCCCAAACGAGGAGACCT	0.488													9	21					0	0	0	0	T	56468959	T	T	56468959	3	4	295	1	0	0	0	0	1	0	0	0	5235	536	19	1	2850	1	ERC2	3	56468959	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	7326798	56468959	141553471	78	54449											
ZNF654	55279	broad.mit.edu	37	chr3	88189924	88189924	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaccaaatctgacaagtgaAcatacttcatatggcttaat	17	11	5	8	0	2	2	1	2	1	0	2	2	2	2	1	1	3	1	1	1	7	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:88189924A>C	uc003dqv.2	+	1	1663	c.1464A>C	c.(1462-1464)GAA>GAC	p.E488D	CGGBP1_uc003dqu.2_Intron	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TGACAAGTGAACATACTTCAT	0.413													10	66					0	0	0	0	C	88189924	C	C	88189924	3	2	295	1	0	0	0	0	1	0	0	0	18134	40	2	5	1466	5	ZNF654	3	88189924	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	31720965	88189924	109832506	79	54450											
OR5H15	403274	broad.mit.edu	37	chr3	97887715	97887715	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aagaccctcaccttcatatcCcaatgtacttactccttggg	10	12	5	14	0	2	1	2	0	0	1	4	1	4	1	4	1	2	1	4	1	5	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:97887715C>A	uc011bgu.1	+	1	172	c.172C>A	c.(172-174)CCA>ACA	p.P58T		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCTTCATATCCCAATGTACTT	0.413													33	101					9.77497e-20	1.36972e-19	1	0	A	97887715	A	A	97887715	3	1	295	1	0	0	0	0	1	0	0	0	11215	623	22	4	174	4	OR5H15	3	97887715	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	9697791	97887715	100134715	80	54451											
IMPG2	50939	broad.mit.edu	37	chr3	100963523	100963523	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagatgttaaggacacatcaGagtcttccatggatggtatt	13	12	10	6	0	2	2	1	0	1	2	3	4	3	4	1	3	0	2	1	3	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:100963523G>C	uc003duq.1	-	13	1855	c.1652C>G	c.(1651-1653)TCT>TGT	p.S551C	IMPG2_uc011bhe.1_Missense_Mutation_p.S414C	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	551	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGACACATCAGAGTCTTCCAT	0.393													23	76					0	0	0	0	C	100963523	C	C	100963523	3	2	295	1	0	0	0	0	1	0	0	0	7768	942	33	2	2101	2	IMPG2	3	100963523	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3075808	100963523	97058907	81	54452											
PHLDB2	90102	broad.mit.edu	37	chr3	111632432	111632432	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agcagtgccagcttctttacCcccaggagcaccaggaatga	11	7	10	13	0	1	1	0	1	1	0	1	3	1	3	4	2	5	3	4	2	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:111632432C>T	uc010hqa.2	+	3	2013	c.1602C>T	c.(1600-1602)ACC>ACT	p.T534T	PHLDB2_uc003dyc.2_Silent_p.T561T|PHLDB2_uc003dyd.2_Silent_p.T534T|PHLDB2_uc003dyg.2_Silent_p.T534T|PHLDB2_uc003dyh.2_Silent_p.T534T|PHLDB2_uc003dyi.2_Silent_p.T120T|PHLDB2_uc003dyf.3_Silent_p.T534T	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	534						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GCTTCTTTACCCCCAGGAGCA	0.562													30	84					0	0	0	0	T	111632432	T	T	111632432	2	4	295	1	0	0	0	0	0	0	0	1	11907	610	22	4		4	PHLDB2	3	111632432	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	10668909	111632432	86389998	82	54453											
SLC9A10	285335	broad.mit.edu	37	chr3	111958692	111958692	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atattacttgcttaccatgtAtgggttttcaagtgtaattg	10	18	8	5	0	1	0	1	0	0	0	1	0	1	0	1	1	3	4	1	1	6	9			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:111958692A>G	uc003dyu.2	-	12	1663	c.1441T>C	c.(1441-1443)TAC>CAC	p.Y481H	SLC9A10_uc011bhu.1_5'UTR|SLC9A10_uc010hqc.2_Missense_Mutation_p.Y433H	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	481					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						CTTACCATGTATGGGTTTTCA	0.308													5	15					0	0	0	0	G	111958692	G	G	111958692	3	3	295	1	0	0	0	0	1	0	0	0	14774	449	16	5	2164	5	SLC9A10	3	111958692	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	326260	111958692	86063738	83	54454											
FBXO40	51725	broad.mit.edu	37	chr3	121342100	121342100	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgatgaggaatatctgtgcCactttgttacaagagagagg	12	11	12	6	0	1	4	0	2	1	2	1	6	1	5	1	2	2	1	1	2	4	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:121342100C>A	uc003eeg.2	+	3	2034	c.1824C>A	c.(1822-1824)GCC>GCA	p.A608A		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	608	F-box.				muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		ATATCTGTGCCACTTTGTTAC	0.507													21	81					1.9806e-07	2.27007e-07	1	0	A	121342100	A	A	121342100	2	1	295	1	0	0	0	0	0	0	0	1	5781	581	21	4		4	FBXO40	3	121342100	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	9383408	121342100	76680330	84	54455											
IQCB1	9657	broad.mit.edu	37	chr3	121500720	121500720	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acttcgctaggaatttaagcGcctggaagaaaaaaaattga	17	9	9	6	2	0	2	0	1	0	1	1	4	0	4	1	2	1	1	1	2	8	5	rs138646990		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:121500720G>A	uc010hre.1	-	13	1495	c.1280C>T	c.(1279-1281)GCG>GTG	p.A427V	IQCB1_uc003eek.2_Missense_Mutation_p.A294V|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	427	IQ 4.				cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		GAATTTAAGCGCCTGGAAGAA	0.388													22	56					0	0	0	0	A	121500720	A	A	121500720	3	1	295	1	0	0	0	0	1	0	0	0	7842	1101	38	1	528	1	IQCB1	3	121500720	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	158620	121500720	76521710	85	54456											
PLXNA1	5361	broad.mit.edu	37	chr3	126723963	126723963	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcctggaacgtgcctgacCtctcagctggcgtcaactgc	7	8	12	14	2	2	1	2	1	1	0	3	2	2	2	3	3	5	1	3	3	2	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:126723963C>T	uc003ejg.2	+	6	1709	c.1705C>T	c.(1705-1707)CTC>TTC	p.L569F		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	592	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CGTGCCTGACCTCTCAGCTGG	0.657													11	36					0	0	0	0	T	126723963	T	T	126723963	3	4	295	1	0	0	0	0	1	0	0	0	12174	681	24	4	1796	4	PLXNA1	3	126723963	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	5223243	126723963	71298467	86	54457											
PLXNA1	5361	broad.mit.edu	37	chr3	126733570	126733570	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaggatcgtctgtgagatcGgggacgccagctccgtgcgt	7	8	15	11	5	1	1	0	1	1	1	4	4	2	3	2	3	2	1	2	3	0	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:126733570G>A	uc003ejg.2	+	13	2708	c.2704G>A	c.(2704-2706)GGG>AGG	p.G902R		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	925	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CTGTGAGATCGGGGACGCCAG	0.577													9	21					0	0	0	0	A	126733570	A	A	126733570	3	1	295	1	0	0	0	0	1	0	0	0	12174	1116	39	1	2823	1	PLXNA1	3	126733570	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	9607	126733570	71288860	87	54458											
BFSP2	8419	broad.mit.edu	37	chr3	133119261	133119261	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atggtgctgttgaggacctaGggggctgcctggtggaatat	7	11	17	6	0	0	1	0	1	0	0	0	3	0	3	2	6	2	3	2	6	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:133119261G>T	uc003epn.1	+	1	472	c.334G>T	c.(334-336)GGG>TGG	p.G112W		NM_003571	NP_003562	Q13515	BFSP2_HUMAN	phakinin	112	Head.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens				0						TGAGGACCTAGGGGGCTGCCT	0.607													30	55					6.03168e-27	8.78229e-27	1	0	T	133119261	T	T	133119261	3	4	295	1	0	0	0	0	1	0	0	0	1419	1000	35	4	336	4	BFSP2	3	133119261	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	6385691	133119261	64903169	88	54459											
KY	339855	broad.mit.edu	37	chr3	134348510	134348510	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctggggcatggcatctcgaGggtggacttccacagtcagt	7	9	15	10	1	2	0	1	0	1	0	4	2	3	1	1	5	0	3	1	5	0	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:134348510G>A	uc010hty.2	-	4	352	c.290C>T	c.(289-291)CCT>CTT	p.P97L	KY_uc011blw.1_Missense_Mutation_p.P97L|KY_uc011blx.1_Missense_Mutation_p.P76L|KY_uc003eqs.1_Missense_Mutation_p.P117L	NM_178554	NP_848649	Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	97						cytoskeleton|Z disc	peptidase activity			ovary(2)	2						GGCATCTCGAGGGTGGACTTC	0.507													3	7					0	0	0	0	A	134348510	A	A	134348510	3	1	295	1	0	0	0	0	1	0	0	0	8626	1000	35	4	1727	4	KY	3	134348510	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1229249	134348510	63673920	89	54460											
ATR	545	broad.mit.edu	37	chr3	142186867	142186867	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttcatatgaatagctttaTtgaggatttccttgcatctg	9	19	7	6	0	2	2	1	2	1	0	3	3	3	3	1	1	2	2	1	1	4	9			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:142186867T>C	uc003eux.3	-	39	6718	c.6596A>G	c.(6595-6597)AAT>AGT	p.N2199S	ATR_uc003euy.1_Missense_Mutation_p.N85S	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2199					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						AATAGCTTTATTGAGGATTTC	0.333								Other_conserved_DNA_damage_response_genes					20	61					0	0	0	0	C	142186867	C	C	142186867	3	2	295	1	0	0	0	0	1	0	0	0	1206	1493	52	5	1374	5	ATR	3	142186867	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	7838357	142186867	55835563	90	54461											
MME	4311	broad.mit.edu	37	chr3	154866441	154866441	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaaaaggtggacaaagatGagtgcgtatattctcatttc	14	11	11	5	1	1	3	1	1	1	2	3	5	1	4	0	2	1	1	0	2	5	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:154866441G>C	uc010hvr.1	+	16	1811	c.1600G>C	c.(1600-1602)GAG>CAG	p.E534Q	MME_uc003fab.1_Missense_Mutation_p.E534Q|MME_uc003fac.1_Missense_Mutation_p.E534Q|MME_uc003fad.1_Missense_Mutation_p.E534Q|MME_uc003fae.1_Missense_Mutation_p.E534Q	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	534	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GGACAAAGATGAGTGCGTATA	0.348													12	25					0	0	0	0	C	154866441	C	C	154866441	3	2	295	1	0	0	0	0	1	0	0	0	9698	1304	45	2	1658	2	MME	3	154866441	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	12679574	154866441	43155989	91	54462											
SCHIP1	29970	broad.mit.edu	37	chr3	159605505	159605505	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccctttgcagagcaaacaGagttcttcctattctgatag	10	14	7	10	0	2	3	0	1	2	2	4	3	4	3	2	0	3	3	2	0	3	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:159605505G>C	uc003fcs.1	+	5	1071	c.1005G>C	c.(1003-1005)CAG>CAC	p.Q335H	SCHIP1_uc003fcq.1_Missense_Mutation_p.Q411H|SCHIP1_uc003fcr.1_Missense_Mutation_p.Q324H|SCHIP1_uc003fct.1_Missense_Mutation_p.Q322H|SCHIP1_uc010hvz.1_Missense_Mutation_p.Q295H|SCHIP1_uc003fcu.1_Missense_Mutation_p.Q92H|SCHIP1_uc003fcv.1_Missense_Mutation_p.Q108H	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	335						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			AGAGCAAACAGAGTTCTTCCT	0.468													55	167					0	0	0	0	C	159605505	C	C	159605505	3	2	295	1	0	0	0	0	1	0	0	0	13969	933	33	2	1023	2	SCHIP1	3	159605505	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	4739064	159605505	38416925	92	54463											
NMD3	51068	broad.mit.edu	37	chr3	160964156	160964156	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtctgggtacagaagacAtctgaaatgaatacagataa	18	8	10	5	0	2	5	0	2	2	3	2	6	2	5	0	1	2	1	0	1	7	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:160964156A>G	uc003feb.1	+	12	1169	c.1050A>G	c.(1048-1050)ACA>ACG	p.T350T	NMD3_uc003fec.2_Silent_p.T350T|NMD3_uc003fed.1_Silent_p.T350T|NMD3_uc010hwh.2_Silent_p.T170T	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	350					protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TACAGAAGACATCTGAAATGA	0.358													9	38					0	0	0	0	G	160964156	G	G	160964156	2	3	295	1	0	0	0	0	0	0	0	1	10542	204	8	5		5	NMD3	3	160964156	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	1358651	160964156	37058274	93	54464											
SLITRK3	22865	broad.mit.edu	37	chr3	164906463	164906463	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtcgaccaccacccccaCttccgccaccaccacctcca	8	6	4	23	2	0	0	0	0	0	0	3	1	2	0	10	1	0	0	10	1	0	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:164906463C>A	uc003fej.3	-	2	2600	c.2156G>T	c.(2155-2157)AGT>ATT	p.S719I	SLITRK3_uc003fek.2_Missense_Mutation_p.S719I	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	719	Poly-Gly.|Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						accacccccacttccgccacc	0.453										HNSCC(40;0.11)			10	25					1.11149e-13	1.46559e-13	1	0	A	164906463	A	A	164906463	3	1	295	1	0	0	0	0	1	0	0	0	14808	565	20	4	781	4	SLITRK3	3	164906463	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	3942307	164906463	33115967	94	54465											
SLITRK3	22865	broad.mit.edu	37	chr3	164908115	164908115	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatttacttaggttccgaaaTgccccactctcaatacgttt	11	14	5	11	2	1	0	1	0	1	0	3	1	2	0	3	1	3	2	3	1	6	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:164908115T>A	uc003fej.3	-	2	948	c.504A>T	c.(502-504)GCA>GCT	p.A168A	SLITRK3_uc003fek.2_Silent_p.A168A	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	168	LRR 4.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GGTTCCGAAATGCCCCACTCT	0.383										HNSCC(40;0.11)			13	57					0	0	0	0	A	164908115	A	A	164908115	2	1	295	1	0	0	0	0	0	0	0	1	14808	1451	51	5		5	SLITRK3	3	164908115	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	1652	164908115	33114315	95	54466											
YEATS2	55689	broad.mit.edu	37	chr3	183479353	183479353	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cccaattgggagtcaccctaAggttcaaagccccaaaccta	13	7	7	14	0	2	0	2	0	0	0	2	1	2	1	5	2	2	1	5	2	5	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:183479353A>T	uc003fly.2	+	14	1910	c.1715A>T	c.(1714-1716)AAG>ATG	p.K572M		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	572					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGTCACCCTAAGGTTCAAAGC	0.413													34	118					0	0	0	0	T	183479353	T	T	183479353	3	4	295	1	0	0	0	0	1	0	0	0	17540	72	3	5	1765	5	YEATS2	3	183479353	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	18571238	183479353	14543077	96	54467											
FETUB	26998	broad.mit.edu	37	chr3	186358445	186358445	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctatgtgctgagactcaacCgagtgaacgacgcccaggaa	12	6	12	11	3	1	2	1	2	0	1	1	6	1	3	2	1	3	2	2	1	4	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:186358445C>G	uc010hyq.2	+	2	457	c.196C>G	c.(196-198)CGA>GGA	p.R66G	FETUB_uc011brz.1_Intron|FETUB_uc003fqn.2_Missense_Mutation_p.R66G|FETUB_uc003fqo.2_5'UTR|FETUB_uc010hyr.2_Missense_Mutation_p.R66G|FETUB_uc010hys.2_5'UTR|FETUB_uc003fqp.3_Missense_Mutation_p.R66G	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	66	Cystatin fetuin-B-type 1.					extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		GAGACTCAACCGAGTGAACGA	0.572													44	132					0	0	0	0	G	186358445	G	G	186358445	3	3	295	1	0	0	0	0	1	0	0	0	5853	644	23	3	198	3	FETUB	3	186358445	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2879092	186358445	11663985	97	54468											
FGF12	2257	broad.mit.edu	37	chr3	192125893	192125893	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaggacgtgcctctcgcaCagggagcgcccgtctttgct	5	8	13	15	5	2	0	0	0	2	0	3	3	2	2	3	2	3	2	3	2	0	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:192125893C>T	uc003fsx.2	-	1	946	c.120G>A	c.(118-120)CTG>CTA	p.L40L	FGF12_uc003fsy.2_Intron	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	40					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		GCCTCTCGCACAGGGAGCGCC	0.672													33	134					0	0	0	0	T	192125893	T	T	192125893	2	4	295	1	0	0	0	0	0	0	0	1	5873	465	17	4		4	FGF12	3	192125893	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	5767448	192125893	5896537	98	54469											
ZNF718	255403	broad.mit.edu	37	chr4	59331	59331	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgtgttttcaggaactcgtAacattcagggatgtggccat	10	13	11	7	1	2	0	2	0	0	0	3	2	2	2	1	3	2	2	1	3	2	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:59331A>T	uc003fzt.3	+	6	145	c.12A>T	c.(10-12)TTA>TTT	p.L4F	ZNF595_uc003fzu.1_RNA|ZNF595_uc010iay.1_RNA|ZNF595_uc003fzv.1_Silent_p.V4V|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	4	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		AGGAACTCGTAACATTCAGGG	0.408													21	426					0	0	0	0	T	59331	T	T	59331	3	4	295	1	0	0	0	0	1	0	0	0	18187	349	13	5	18	5	ZNF718	4	59331	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08		59331	191094945	99	54470											
TACC3	10460	broad.mit.edu	37	chr4	1730308	1730308	+	Frame_Shift_Del	DEL	C	-	-																															aggagcggagcaggagaggaCccccccatgccagcttctcg																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:1730308delC	uc003gdo.2	+	4	1287	c.1179delC	c.(1177-1179)GACfs	p.D393fs	TACC3_uc010ibz.2_Frame_Shift_Del_p.D393fs|TACC3_uc003gdp.2_Intron|TACC3_uc010ica.2_5'Flank	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	393						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CAGGAGAGGACCCCCCCATGC	0.612													---	---	---								-	1730308	-	-	1730308	7	5	295	1	0	1	0	1	0	0	0	0	15569	506	18	0	1189	0	TACC3	4	1730308	Frame_Shift_Del	DEL	C	TCGA-F7-7848-01A-11D-2129-08	1670977	1730308	189423968	100	54471											
WHSC1	7468	broad.mit.edu	37	chr4	1902706	1902706	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccaggaaatgaaagggattGggacaccccctaacactacc	14	5	9	13	0	0	1	0	1	0	0	0	4	0	4	4	3	2	0	4	3	4	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:1902706G>T	uc003gdz.3	+	2	501	c.325G>T	c.(325-327)GGG>TGG	p.G109W	WHSC1_uc003geb.3_Missense_Mutation_p.G109W|WHSC1_uc003gec.3_Missense_Mutation_p.G109W|WHSC1_uc003ged.3_Missense_Mutation_p.G109W|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdx.2_Missense_Mutation_p.G109W|WHSC1_uc003gdy.1_Missense_Mutation_p.G109W|WHSC1_uc010icd.1_Missense_Mutation_p.G109W|WHSC1_uc003gea.1_Missense_Mutation_p.G109W|WHSC1_uc010ice.1_Missense_Mutation_p.G109W|WHSC1_uc003geg.1_Missense_Mutation_p.G109W|WHSC1_uc003geh.1_Missense_Mutation_p.G109W	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	109					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GAAAGGGATTGGGACACCCCC	0.463			T	IGH@	MM								25	67					4.22769e-11	5.33836e-11	1	0	T	1902706	T	T	1902706	3	4	295	1	0	0	0	0	1	0	0	0	17430	1348	47	4	327	4	WHSC1	4	1902706	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	172398	1902706	189251570	101	54472											
WHSC1	7468	broad.mit.edu	37	chr4	1980436	1980436	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cttcattttgccacctctgcCccaattcgttctgtaaggag	7	14	7	13	1	3	0	1	0	2	0	4	1	3	1	4	1	2	2	4	1	2	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:1980436C>A	uc003gdz.3	+	22	4074	c.3898C>A	c.(3898-3900)CCC>ACC	p.P1300T	WHSC1_uc003geb.3_Missense_Mutation_p.P1300T|WHSC1_uc003gec.3_Missense_Mutation_p.P1300T|WHSC1_uc003ged.3_Missense_Mutation_p.P1300T|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.P519T|WHSC1_uc011bvh.1_Missense_Mutation_p.P361T|WHSC1_uc010icf.2_Missense_Mutation_p.P648T	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1300					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CCACCTCTGCCCCAATTCGTT	0.562			T	IGH@	MM								27	38					1.33986e-20	1.89531e-20	1	0	A	1980436	A	A	1980436	3	1	295	1	0	0	0	0	1	0	0	0	17430	623	22	4	4056	4	WHSC1	4	1980436	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	77730	1980436	189173840	102	54473											
HTT	3064	broad.mit.edu	37	chr4	3182271	3182271	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctctgcagcccatagtccacGacctctttgtattaagagga	10	11	8	12	1	2	1	0	0	2	1	3	3	3	2	3	1	2	2	3	1	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:3182271G>A	uc011bvq.1	+	37	4793	c.4648G>A	c.(4648-4650)GAC>AAC	p.D1550N		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1548					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CATAGTCCACGACCTCTTTGT	0.443													25	76					0	0	0	0	A	3182271	A	A	3182271	3	1	295	1	0	0	0	0	1	0	0	0	7496	1058	37	1	4784	1	HTT	4	3182271	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1201835	3182271	187972005	103	54474											
WFS1	7466	broad.mit.edu	37	chr4	6302728	6302728	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacttcggctggaaccacctGgagccctatgcccatttcct	8	10	8	15	1	0	0	0	0	0	0	2	2	1	2	5	3	4	1	5	3	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:6302728G>C	uc003giy.2	+	8	1372	c.1206G>C	c.(1204-1206)CTG>CTC	p.L402L	WFS1_uc003gix.2_Silent_p.L402L|WFS1_uc003giz.2_Silent_p.L220L	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	402	Helical; (Potential).				endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		GGAACCACCTGGAGCCCTATG	0.607													42	172					0	0	0	0	C	6302728	C	C	6302728	2	2	295	1	0	0	0	0	0	0	0	1	17428	1335	47	4		4	WFS1	4	6302728	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3120457	6302728	184851548	104	54475											
C4orf23	152992	broad.mit.edu	37	chr4	8477672	8477672	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cggactgctgcccgtttgccCatgggcctgcggagctgcgg	3	8	16	14	4	0	0	0	0	0	0	0	2	0	2	3	4	6	3	3	4	0	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:8477672C>T	uc003glg.1	+	11	1719	c.1531C>T	c.(1531-1533)CAT>TAT	p.H511Y	C4orf23_uc003glh.1_Missense_Mutation_p.H348Y|C4orf23_uc003gli.1_RNA	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	740					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						CCCGTTTGCCCATGGGCCTGC	0.622													25	172					0	0	0	0	T	8477672	T	T	8477672	3	4	295	1	0	0	0	0	1	0	0	0	2266	594	21	4	2260	4	C4orf23	4	8477672	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2174944	8477672	182676604	105	54476											
GABRA2	2555	broad.mit.edu	37	chr4	46252411	46252411	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accaaacaaaactggaaaaaCtattctggacattctgtcaa	18	9	5	9	0	3	0	1	0	2	0	3	2	3	2	1	2	3	0	1	2	7	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:46252411C>G	uc003gxc.3	-	9	1943	c.1270G>C	c.(1270-1272)GTT>CTT	p.V424L	GABRA2_uc010igc.2_Missense_Mutation_p.V424L|GABRA2_uc011bzc.1_Missense_Mutation_p.V429L	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	424	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACTGGAAAAACTATTCTGGAC	0.393													32	84					0	0	0	0	G	46252411	G	G	46252411	3	3	295	1	0	0	0	0	1	0	0	0	6195	565	20	4	89	4	GABRA2	4	46252411	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	37774739	46252411	144901865	106	54477											
PDGFRA	5156	broad.mit.edu	37	chr4	55161418	55161418	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcatagactcttcagacctGgtggaagacagcttcctgta	10	10	11	10	0	2	3	1	0	1	3	3	4	3	4	2	3	1	3	2	3	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:55161418G>T	uc003han.3	+	23	3580	c.3249G>T	c.(3247-3249)CTG>CTT	p.L1083L	PDGFRA_uc003haa.2_Silent_p.L843L	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	1083	Ser-rich.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTTCAGACCTGGTGGAAGACA	0.512			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			30	85					1.61788e-16	2.20485e-16	1	0	T	55161418	T	T	55161418	2	4	295	1	0	0	0	0	0	0	0	1	11715	1335	47	4		4	PDGFRA	4	55161418	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	8909007	55161418	135992858	107	54478											
EXOC1	55763	broad.mit.edu	37	chr4	56763010	56763010	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatcttcaaaaatgctgagcGtcgtggagacctggataaag	14	9	11	7	2	2	2	1	1	1	1	3	4	2	3	1	2	2	1	1	2	5	2	rs142941850	by1000genomes	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:56763010G>T	uc003hbe.1	+	16	2239	c.2081G>T	c.(2080-2082)CGT>CTT	p.R694L	EXOC1_uc003hbf.1_Missense_Mutation_p.R694L|EXOC1_uc003hbg.1_Missense_Mutation_p.R679L	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	694					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					AATGCTGAGCGTCGTGGAGAC	0.338													12	36					2.27111e-07	2.58976e-07	1	0	T	56763010	T	T	56763010	3	4	295	1	0	0	0	0	1	0	0	0	5325	1145	40	3	2139	3	EXOC1	4	56763010	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1601592	56763010	134391266	108	54479											
YTHDC1	91746	broad.mit.edu	37	chr4	69184563	69184563	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtccacttcctggtatcGtggatcctttaaataccctg	7	14	7	13	1	0	0	0	0	0	0	4	1	3	1	5	2	1	1	5	2	4	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:69184563G>A	uc003hdx.2	-	13	2055	c.1702C>T	c.(1702-1704)CGA>TGA	p.R568*	YTHDC1_uc003hdy.2_Nonsense_Mutation_p.R550*	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	568	Arg-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						TCCTGGTATCGTGGATCCTTT	0.328													9	77					0	0	0	0	A	69184563	A	A	69184563	4	1	295	1	0	0	0	0	0	1	0	0	17564	1153	40	1	501	1	YTHDC1	4	69184563	Nonsense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	12421553	69184563	121969713	109	54480											
UGT2B15	7366	broad.mit.edu	37	chr4	69519826	69519826	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atggtcctgatgtccacactGagggctgctcccttggcttt	5	13	11	12	0	0	2	0	2	0	0	3	2	3	2	3	3	1	3	3	3	0	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:69519826G>A	uc011cal.1	-	5	1280	c.1242C>T	c.(1240-1242)CTC>CTT	p.L414L		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	414					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						TGTCCACACTGAGGGCTGCTC	0.468													50	127					0	0	0	0	A	69519826	A	A	69519826	2	1	295	1	0	0	0	0	0	0	0	1	17026	1277	45	2		2	UGT2B15	4	69519826	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	335263	69519826	121634450	110	54481											
BTC	685	broad.mit.edu	37	chr4	75675872	75675872	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaatctgtcctctgtctccTcttaggtaaaacaagtcaac	12	12	6	11	0	5	1	1	0	4	1	7	1	6	1	2	1	2	1	2	1	6	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:75675872T>A	uc003hig.2	-	4	686	c.339A>T	c.(337-339)AGA>AGT	p.R113S		NM_001729	NP_001720	P35070	BTC_HUMAN	betacellulin precursor	113	Extracellular (Potential).				positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|skin(1)	2			Lung(101;0.219)			CTCTGTCTCCTCTTAGGTAAA	0.398													51	164					0	0	0	0	A	75675872	A	A	75675872	3	1	295	1	0	0	0	0	1	0	0	0	1554	1548	54	5	205	5	BTC	4	75675872	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	6156046	75675872	115478404	111	54482											
ART3	419	broad.mit.edu	37	chr4	77003168	77003168	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagactcaaatctttctcccTatgaattttaaggataacca	15	13	4	9	0	3	2	1	1	2	1	4	3	3	3	2	1	1	0	2	1	6	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:77003168T>C	uc003hjo.2	+	3	380	c.261T>C	c.(259-261)CCT>CCC	p.P87P	ART3_uc003hji.2_Silent_p.P87P|ART3_uc003hjj.2_Silent_p.P87P|ART3_uc003hjk.2_Silent_p.P87P|ART3_uc010ija.1_Silent_p.P87P|ART3_uc003hjn.2_Silent_p.P87P|ART3_uc003hjp.2_Intron|ART3_uc010ijb.2_Intron|ART3_uc003hjq.2_Intron|ART3_uc003hjr.2_Silent_p.P57P|ART3_uc010ijc.2_Silent_p.P57P|ART3_uc010ijd.2_Silent_p.P57P	NM_001130016	NP_001123488	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3 isoform a	87					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			ovary(2)	2			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCTTTCTCCCTATGAATTTTA	0.423													27	53					0	0	0	0	C	77003168	C	C	77003168	2	2	295	1	0	0	0	0	0	0	0	1	1000	1509	53	5		5	ART3	4	77003168	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	1327296	77003168	114151108	112	54483											
GK2	2712	broad.mit.edu	37	chr4	80327826	80327826	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactggtaacccaacccattGacttcattacggctttcttc	9	13	6	13	1	2	1	1	1	1	0	3	2	2	1	2	2	3	2	2	2	3	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:80327826G>A	uc003hlu.2	-	1	1547	c.1529C>T	c.(1528-1530)TCA>TTA	p.S510L		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	510					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						CCAACCCATTGACTTCATTAC	0.443													19	74					0	0	0	0	A	80327826	A	A	80327826	3	1	295	1	0	0	0	0	1	0	0	0	6458	1294	45	2	136	2	GK2	4	80327826	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3324658	80327826	110826450	113	54484											
SLC39A8	64116	broad.mit.edu	37	chr4	103225478	103225478	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggaattaacatatacctgtAgagataccacactgacatta	16	11	6	8	0	0	2	0	1	0	1	0	4	0	3	2	1	3	1	2	1	7	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:103225478A>G	uc003hwb.1	-	5	1365	c.836T>C	c.(835-837)CTA>CCA	p.L279P	SLC39A8_uc011ceo.1_Missense_Mutation_p.L279P|SLC39A8_uc003hwa.1_Missense_Mutation_p.L212P|SLC39A8_uc003hwc.2_Missense_Mutation_p.L279P	NM_022154	NP_071437	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter),	279	Extracellular (Potential).					integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		ATATACCTGTAGAGATACCAC	0.348													5	33					0	0	0	0	G	103225478	G	G	103225478	3	3	295	1	0	0	0	0	1	0	0	0	14688	420	15	5	639	5	SLC39A8	4	103225478	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	22897652	103225478	87928798	114	54485											
ANK2	287	broad.mit.edu	37	chr4	114179511	114179511	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggctgccttcatgggccacTtgaacattgtcctccttctg	5	14	9	13	0	2	1	1	1	1	0	4	1	4	1	4	2	2	1	4	2	1	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:114179511T>C	uc003ibe.3	+	13	1430	c.1330T>C	c.(1330-1332)TTG>CTG	p.L444L	ANK2_uc003ibd.3_Silent_p.L423L|ANK2_uc003ibf.3_Silent_p.L444L|ANK2_uc003ibc.2_Silent_p.L420L|ANK2_uc011cgb.1_Silent_p.L459L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	444	ANK 13.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CATGGGCCACTTGAACATTGT	0.532													15	86					0	0	0	0	C	114179511	C	C	114179511	2	2	295	1	0	0	0	0	0	0	0	1	621	1606	56	5		5	ANK2	4	114179511	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	10954033	114179511	76974765	115	54486											
NUDT6	11162	broad.mit.edu	37	chr4	123814172	123814172	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttgtattttcagtcttcgcCaggtcattgagatccatcca	8	15	8	10	1	3	1	2	1	1	1	6	2	5	1	3	1	0	2	3	1	1	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:123814172C>A	uc003iew.2	-	5	794	c.762G>T	c.(760-762)CTG>CTT	p.L254L	FGF2_uc003iev.1_3'UTR|NUDT6_uc003iex.2_Silent_p.L85L	NM_007083	NP_009014	P53370	NUDT6_HUMAN	nudix-type motif 6 isoform a	254	Nudix hydrolase.					mitochondrion|nucleus	growth factor activity|hydrolase activity				0						CAGTCTTCGCCAGGTCATTGA	0.438													31	95					1.08312e-15	1.45392e-15	1	0	A	123814172	A	A	123814172	2	1	295	1	0	0	0	0	0	0	0	1	10797	581	21	4		4	NUDT6	4	123814172	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	9634661	123814172	67340104	116	54487											
ANKRD50	57182	broad.mit.edu	37	chr4	125593009	125593009	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgtaccattccatatcaTccacagagctaactccgctg	11	10	7	13	1	1	1	1	0	0	1	4	1	4	1	4	1	3	3	4	1	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:125593009T>G	uc003ifg.3	-	3	1689	c.1423A>C	c.(1423-1425)ATG>CTG	p.M475L	ANKRD50_uc011cgo.1_Missense_Mutation_p.M296L|ANKRD50_uc010inw.2_Missense_Mutation_p.M475L	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	475										central_nervous_system(1)	1						TTCCATATCATCCACAGAGCT	0.413													19	63					0	0	0	0	G	125593009	G	G	125593009	3	3	295	1	0	0	0	0	1	0	0	0	677	1435	50	5	2870	5	ANKRD50	4	125593009	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	1778837	125593009	65561267	117	54488											
PCDH10	57575	broad.mit.edu	37	chr4	134072306	134072306	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggacctgggccccaacgcCgtgcctgcgcactgcaaggt	8	5	13	15	3	0	0	0	0	0	0	0	1	0	1	5	3	4	2	5	3	3	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:134072306C>A	uc003iha.2	+	1	1837	c.1011C>A	c.(1009-1011)GCC>GCA	p.A337A	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.A337A	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	337	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCCCCAACGCCGTGCCTGCGC	0.607													26	75					2.79863e-10	3.45577e-10	1	0	A	134072306	A	A	134072306	2	1	295	1	0	0	0	0	0	0	0	1	11561	639	23	3		3	PCDH10	4	134072306	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	8479297	134072306	57081970	118	54489											
MAB21L2	10586	broad.mit.edu	37	chr4	151504976	151504976	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaccgccacctggagctaccCggccagccgctcaacaacta	10	4	9	18	3	1	0	1	0	0	0	1	2	1	1	6	2	5	2	6	2	4	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:151504976C>A	uc003ilw.2	+	1	1900	c.795C>A	c.(793-795)CCC>CCA	p.P265P	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	265					nervous system development	nucleus		p.P265T(1)		ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		TGGAGCTACCCGGCCAGCCGC	0.627													23	38					2.89027e-11	3.65991e-11	1	0	A	151504976	A	A	151504976	2	1	295	1	0	0	0	0	0	0	0	1	9193	639	23	3		3	MAB21L2	4	151504976	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	17432670	151504976	39649300	119	54490											
FGA	2243	broad.mit.edu	37	chr4	155507623	155507623	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agagctcccaggtttccaggTtgcagtccctccagtcccag	7	9	10	15	0	0	1	0	0	0	1	5	1	5	1	5	2	2	4	5	2	0	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:155507623T>C	uc003iod.1	-	5	1016	c.958A>G	c.(958-960)ACC>GCC	p.T320A	FGA_uc003ioe.1_Missense_Mutation_p.T320A|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	320	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GGTTTCCAGGTTGCAGTCCCT	0.572													46	123					0	0	0	0	C	155507623	C	C	155507623	3	2	295	1	0	0	0	0	1	0	0	0	5862	1725	60	5	1694	5	FGA	4	155507623	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	4002647	155507623	35646653	120	54491											
GUCY1A3	2982	broad.mit.edu	37	chr4	156632130	156632130	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tccctgtcccccagcaaaccCcagtcctcgctggtgattcc	6	9	7	19	1	0	1	0	1	0	0	5	1	4	1	7	1	2	2	7	1	1	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:156632130C>A	uc003iov.2	+	7	1349	c.813C>A	c.(811-813)CCC>CCA	p.P271P	GUCY1A3_uc003iou.2_Silent_p.P271P|GUCY1A3_uc010iqc.2_Silent_p.P271P|GUCY1A3_uc003iow.2_Silent_p.P271P|GUCY1A3_uc010iqd.2_Silent_p.P270P|GUCY1A3_uc003iox.2_Silent_p.P271P|GUCY1A3_uc003ioz.2_Silent_p.P36P|GUCY1A3_uc003ioy.2_Silent_p.P271P|GUCY1A3_uc010iqe.2_Silent_p.P36P|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Silent_p.P271P	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	271					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CCAGCAAACCCCAGTCCTCGC	0.463													17	48					0.00152264	0.00158653	1	0	A	156632130	A	A	156632130	2	1	295	1	0	0	0	0	0	0	0	1	6933	610	22	4		4	GUCY1A3	4	156632130	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	1124507	156632130	34522146	121	54492											
FSTL5	56884	broad.mit.edu	37	chr4	162376271	162376271	+	Frame_Shift_Del	DEL	G	-	-																															aggcacattcccactggccaGggtaattacctaaagagaac																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:162376271delG	uc003iqh.2	-	15	2162	c.1726delC	c.(1726-1728)CTGfs	p.L576fs	FSTL5_uc003iqi.2_Frame_Shift_Del_p.L575fs|FSTL5_uc010iqv.2_Frame_Shift_Del_p.L566fs	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	576						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CCACTGGCCAGGGTAATTACC	0.403													---	---	---								-	162376271	-	-	162376271	7	5	295	1	0	1	0	1	0	0	0	0	6114	991	35	0	825	0	FSTL5	4	162376271	Frame_Shift_Del	DEL	G	TCGA-F7-7848-01A-11D-2129-08	5744141	162376271	28778005	122	54493											
FSTL5	56884	broad.mit.edu	37	chr4	162841715	162841715	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catacaggcacattctgcttGccctgtctctctgctggtaa	7	13	8	13	0	3	0	0	0	3	0	4	0	3	0	1	2	4	4	1	2	2	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:162841715G>T	uc003iqh.2	-	4	686	c.250C>A	c.(250-252)CAA>AAA	p.Q84K	FSTL5_uc003iqi.2_Missense_Mutation_p.Q83K|FSTL5_uc010iqv.2_Missense_Mutation_p.Q83K	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	84	Kazal-like.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CATTCTGCTTGCCCTGTCTCT	0.443													10	21					2.17888e-05	2.36398e-05	1	0	T	162841715	T	T	162841715	3	4	295	1	0	0	0	0	1	0	0	0	6114	1328	46	4	2345	4	FSTL5	4	162841715	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	465444	162841715	28312561	123	54494											
NPY1R	4886	broad.mit.edu	37	chr4	164247554	164247554	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttccagagacaccaagaatGatcacagctccataagcaag	16	7	7	11	0	1	3	1	1	0	2	3	4	3	3	3	0	2	2	3	0	4	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:164247554G>T	uc003iqm.1	-	2	419	c.153C>A	c.(151-153)ATC>ATA	p.I51I	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	51	Helical; Name=1; (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CACCAAGAATGATCACAGCTC	0.413													28	64					1.88708e-17	2.60348e-17	1	0	T	164247554	T	T	164247554	2	4	295	1	0	0	0	0	0	0	0	1	10662	1280	45	2		2	NPY1R	4	164247554	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1405839	164247554	26906722	124	54495											
TLL1	7092	broad.mit.edu	37	chr4	166910564	166910564	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcgatattgccttagatgaTgaagacttaaatatctttca	13	14	8	6	1	2	4	1	2	1	2	2	5	2	4	1	1	1	0	1	1	6	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:166910564T>A	uc003irh.1	+	2	848	c.201T>A	c.(199-201)GAT>GAA	p.D67E	TLL1_uc011cjn.1_Missense_Mutation_p.D67E|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	67					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CCTTAGATGATGAAGACTTAA	0.333													21	47					0	0	0	0	A	166910564	A	A	166910564	3	1	295	1	0	0	0	0	1	0	0	0	16011	1461	51	5	207	5	TLL1	4	166910564	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	2663010	166910564	24243712	125	54496											
SPOCK3	50859	broad.mit.edu	37	chr4	167663155	167663155	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctattactcacctaggagCttctttaccccttgccgctt	7	15	5	14	1	3	0	1	0	2	0	3	1	3	1	4	1	4	2	4	1	4	8			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:167663155C>A	uc003iri.1	-	10	1137	c.996G>T	c.(994-996)AAG>AAT	p.K332N	SPOCK3_uc011cjp.1_Missense_Mutation_p.K289N|SPOCK3_uc011cjq.1_Missense_Mutation_p.K341N|SPOCK3_uc011cjr.1_Missense_Mutation_p.K212N|SPOCK3_uc003irj.1_Missense_Mutation_p.K329N|SPOCK3_uc011cjs.1_Missense_Mutation_p.K281N|SPOCK3_uc011cjt.1_Missense_Mutation_p.K240N|SPOCK3_uc011cju.1_Missense_Mutation_p.K225N|SPOCK3_uc011cjv.1_Missense_Mutation_p.K234N	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	332	Thyroglobulin type-1.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		CACCTAGGAGCTTCTTTACCC	0.378													18	43					1.9806e-07	2.27007e-07	1	0	A	167663155	A	A	167663155	3	1	295	1	0	0	0	0	1	0	0	0	15147	796	28	4	326	4	SPOCK3	4	167663155	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	752591	167663155	23491121	126	54497											
ODZ3	55714	broad.mit.edu	37	chr4	183600970	183600970	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggattctggaatctggcatcTggctttttataatgatggga	9	15	12	5	0	3	1	0	1	3	0	3	4	3	4	0	5	0	2	0	5	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:183600970T>C	uc003ivd.1	+	7	1515	c.1478T>C	c.(1477-1479)CTG>CCG	p.L493P	ODZ3_uc003ive.1_5'Flank	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	493	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		ATCTGGCATCTGGCTTTTTAT	0.483													11	19					0	0	0	0	C	183600970	C	C	183600970	3	2	295	1	0	0	0	0	1	0	0	0	10890	1580	55	5	1504	5	ODZ3	4	183600970	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	15937815	183600970	7553306	127	54498											
PDLIM3	27295	broad.mit.edu	37	chr4	186446225	186446225	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgctttaatcctgtcctgcGcatcagcatgagtcatggac	8	12	9	12	1	2	1	2	1	0	0	4	2	4	2	2	1	3	3	2	1	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:186446225G>A	uc003ixw.3	-	2	318	c.194C>T	c.(193-195)GCG>GTG	p.A65V	PDLIM3_uc003ixx.3_Missense_Mutation_p.A65V|PDLIM3_uc010isi.2_RNA|PDLIM3_uc003ixy.2_Missense_Mutation_p.A65V|PDLIM3_uc003ixz.2_Missense_Mutation_p.A65V	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	65	PDZ.					sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		CCTGTCCTGCGCATCAGCATG	0.493													29	90					0	0	0	0	A	186446225	A	A	186446225	3	1	295	1	0	0	0	0	1	0	0	0	11735	1087	38	1	1120	1	PDLIM3	4	186446225	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2845255	186446225	4708051	128	54499											
KLKB1	3818	broad.mit.edu	37	chr4	187155174	187155174	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatcgaacaggtgcagtttCtggacattccttgaagcaat	12	11	9	9	1	1	1	0	1	1	0	3	3	2	2	1	2	3	3	1	2	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:187155174C>A	uc003iyy.2	+	4	361	c.290C>A	c.(289-291)TCT>TAT	p.S97Y	KLKB1_uc011clc.1_Translation_Start_Site|KLKB1_uc011cld.1_Missense_Mutation_p.S59Y	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	97	Apple 1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GGTGCAGTTTCTGGACATTCC	0.368													32	84					5.8336e-16	7.90188e-16	1	0	A	187155174	A	A	187155174	3	1	295	1	0	0	0	0	1	0	0	0	8451	913	32	2	300	2	KLKB1	4	187155174	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	708949	187155174	3999102	129	54500											
CTNND2	1501	broad.mit.edu	37	chr5	11082943	11082943	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcttttcggacagcggctcGgatatatactgaccactgca	9	11	9	12	3	1	1	0	1	1	0	3	3	1	3	1	3	3	2	1	3	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:11082943G>A	uc003jfa.1	-	16	2798	c.2653C>T	c.(2653-2655)CGA>TGA	p.R885*	CTNND2_uc010itt.2_Nonsense_Mutation_p.R794*|CTNND2_uc011cmy.1_Nonsense_Mutation_p.R548*|CTNND2_uc011cmz.1_Nonsense_Mutation_p.R452*|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Nonsense_Mutation_p.R477*	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	885	ARM 8.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						ACAGCGGCTCGGATATATACT	0.547													16	36					0	0	0	0	A	11082943	A	A	11082943	4	1	295	1	0	0	0	0	0	1	0	0	4037	1124	39	1	1052	1	CTNND2	5	11082943	Nonsense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08		11082943	169832317	130	54501											
CDH12	1010	broad.mit.edu	37	chr5	21752113	21752113	+	Silent	SNP	G	T	T																															atgtctgtgttatcttccatGggtggtctctgacgaggtaa																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:21752113G>T	uc010iuc.2	-	12	2576	c.2118C>A	c.(2116-2118)CCC>CCA	p.P706P	CDH12_uc011cno.1_Silent_p.P666P|CDH12_uc003jgk.2_Silent_p.P706P|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	706	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TATCTTCCATGGGTGGTCTCT	0.453										HNSCC(59;0.17)			14	58					6.72482e-11	8.44381e-11	1	0	T	21752113	T	T	21752113	2	4	295	1	0	0	0	0	0	0	0	1	3113	1335	47	4		4	CDH12	5	21752113	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	10669170	21752113	159163147	131	54502	127	2									
CDH12	1010	broad.mit.edu	37	chr5	21752115	21752115	+	Missense_Mutation	SNP	G	T	T																															gtctgtgttatcttccatggGtggtctctgacgaggtaaac																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:21752115G>T	uc010iuc.2	-	12	2574	c.2116C>A	c.(2116-2118)CCC>ACC	p.P706T	CDH12_uc011cno.1_Missense_Mutation_p.P666T|CDH12_uc003jgk.2_Missense_Mutation_p.P706T|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	706	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TCTTCCATGGGTGGTCTCTGA	0.448										HNSCC(59;0.17)			14	57					6.72482e-11	8.44381e-11	1	0	T	21752115	T	T	21752115	3	4	295	1	0	0	0	0	1	0	0	0	3113	1261	44	4	272	4	CDH12	5	21752115	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2	21752115	159163145	132	54503	127	2									
CDH9	1007	broad.mit.edu	37	chr5	26903772	26903772	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagttataatcccttcctGtgtatccttgtcagtgatga	9	15	8	9	0	1	2	1	2	0	0	4	3	4	2	3	0	0	2	3	0	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:26903772G>T	uc003jgs.1	-	6	1142	c.973C>A	c.(973-975)CAG>AAG	p.Q325K	CDH9_uc010iug.2_Missense_Mutation_p.Q325K	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	325	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATCCCTTCCTGTGTATCCTTG	0.398													44	112					4.86159e-25	7.05562e-25	1	0	T	26903772	T	T	26903772	3	4	295	1	0	0	0	0	1	0	0	0	3132	1386	48	4	1424	4	CDH9	5	26903772	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	5151657	26903772	154011488	133	54504											
CDH9	1007	broad.mit.edu	37	chr5	26988327	26988327	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcatcttttgtcagaccCgctatctttttgcttgataa	7	17	6	11	2	4	2	2	1	2	1	4	2	4	2	2	0	1	2	2	0	2	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:26988327C>A	uc003jgs.1	-	2	283	c.114G>T	c.(112-114)GCG>GCT	p.A38A	CDH9_uc010iug.2_Silent_p.A38A	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	38					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTGTCAGACCCGCTATCTTTT	0.393													8	31					0.00307968	0.00317925	1	0	A	26988327	A	A	26988327	2	1	295	1	0	0	0	0	0	0	0	1	3132	639	23	3		3	CDH9	5	26988327	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	84555	26988327	153926933	134	54505											
PDZD2	23037	broad.mit.edu	37	chr5	31799682	31799682	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ggcaagaagaggaaaacccaCcagggtcctgtgctggatgt	12	6	14	9	0	0	2	0	0	0	2	1	4	1	4	3	4	2	2	3	4	4	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:31799682C>A	uc003jhl.2	+	2	715	c.327C>A	c.(325-327)CAC>CAA	p.H109Q	PDZD2_uc003jhm.2_Missense_Mutation_p.H109Q	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	109	PDZ 1.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GGAAAACCCACCAGGGTCCTG	0.587													26	87					1.55469e-16	2.12522e-16	1	0	A	31799682	A	A	31799682	3	1	295	1	0	0	0	0	1	0	0	0	11755	506	18	4	329	4	PDZD2	5	31799682	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	4811355	31799682	149115578	135	54506											
UGT3A1	133688	broad.mit.edu	37	chr5	35965518	35965518	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtttaataggtttttccatCaagcctccaatataaacagt	13	14	6	8	0	1	0	1	0	0	0	3	0	3	0	3	2	2	2	3	2	7	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:35965518C>T	uc003jjv.1	-	4	970	c.813G>A	c.(811-813)TTG>TTA	p.L271L	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Silent_p.L271L|UGT3A1_uc011cor.1_Silent_p.L237L|UGT3A1_uc003jjy.1_Silent_p.L217L	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	271	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTTTTTCCATCAAGCCTCCAA	0.448													23	54					0	0	0	0	T	35965518	T	T	35965518	2	4	295	1	0	0	0	0	0	0	0	1	17031	825	29	2		2	UGT3A1	5	35965518	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	4165836	35965518	144949742	136	54507											
SKIV2L2	23517	broad.mit.edu	37	chr5	54683820	54683820	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agcctaactctggtgaactgGatcctttgtatgtagtagaa	11	13	10	7	0	1	2	0	1	1	1	2	3	2	3	2	2	3	3	2	2	6	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:54683820G>A	uc003jpy.3	+	19	2337	c.2071G>A	c.(2071-2073)GAT>AAT	p.D691N	SKIV2L2_uc011cqi.1_Missense_Mutation_p.D590N	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	691					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TGGTGAACTGGATCCTTTGTA	0.373													12	29					0	0	0	0	A	54683820	A	A	54683820	3	1	295	1	0	0	0	0	1	0	0	0	14425	1174	41	2	2145	2	SKIV2L2	5	54683820	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	18718302	54683820	126231440	137	54508											
ACTBL2	345651	broad.mit.edu	37	chr5	56777903	56777903	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acagcttctctttgacatctCgcacaatctcccgctcagca	9	11	5	16	2	4	1	1	1	3	0	7	1	4	1	1	0	2	4	1	0	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:56777903C>T	uc003jrm.2	-	1	734	c.632G>A	c.(631-633)CGA>CAA	p.R211Q		NM_001017992	NP_001017992	Q562R1	ACTBL_HUMAN	actin, beta-like 2	211						cytoplasm|cytoskeleton	ATP binding			ovary(3)	3		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		TTTGACATCTCGCACAATCTC	0.552													23	50					0	0	0	0	T	56777903	T	T	56777903	3	4	295	1	0	0	0	0	1	0	0	0	194	884	31	1	502	1	ACTBL2	5	56777903	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2094083	56777903	124137357	138	54509											
YTHDC2	64848	broad.mit.edu	37	chr5	112920103	112920103	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaggaccgatcagatcagtCttctctgaaatctacagaca	13	10	8	10	1	5	4	2	2	3	2	6	6	5	5	1	1	1	0	1	1	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:112920103C>T	uc003kqn.2	+	26	3935	c.3752C>T	c.(3751-3753)TCT>TTT	p.S1251F		NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1251	Ser-rich.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TCAGATCAGTCTTCTCTGAAA	0.428													28	46					0	0	0	0	T	112920103	T	T	112920103	3	4	295	1	0	0	0	0	1	0	0	0	17565	913	32	2	3854	2	YTHDC2	5	112920103	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	56142200	112920103	67995157	139	54510											
DMXL1	1657	broad.mit.edu	37	chr5	118505977	118505977	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagacgtcattttggatcaTctgatacattttccacacat	11	15	6	9	1	3	2	2	2	1	1	4	4	4	3	1	1	1	0	1	1	1	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:118505977T>A	uc003ksd.2	+	24	5672	c.5491T>A	c.(5491-5493)TCT>ACT	p.S1831T	DMXL1_uc010jcl.1_Missense_Mutation_p.S1831T	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1831										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TTTTGGATCATCTGATACATT	0.353													3	32					0	0	0	0	A	118505977	A	A	118505977	3	1	295	1	0	0	0	0	1	0	0	0	4616	1435	50	5	5585	5	DMXL1	5	118505977	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	5585874	118505977	62409283	140	54511											
FBN2	2201	broad.mit.edu	37	chr5	127730926	127730926	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgggagctcttgtgcacagcGgccattcaccaggcccgaga	8	6	13	14	3	2	1	1	0	1	1	2	3	2	2	3	3	3	2	3	3	0	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:127730926G>C	uc003kuu.2	-	9	1559	c.1120C>G	c.(1120-1122)CGC>GGC	p.R374G	FBN2_uc003kuv.2_Missense_Mutation_p.R341G	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	374	TB 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGTGCACAGCGGCCATTCACC	0.517													8	14					0	0	0	0	C	127730926	C	C	127730926	3	2	295	1	0	0	0	0	1	0	0	0	5735	1116	39	3	7846	3	FBN2	5	127730926	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	9224949	127730926	53184334	141	54512											
SPOCK1	6695	broad.mit.edu	37	chr5	136476329	136476329	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtagtcctgggtcacacacActttgtgagggctgcatttt	7	13	12	9	0	1	1	1	1	0	0	2	1	2	1	1	3	1	3	1	3	1	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:136476329A>C	uc003lbo.2	-	3	478	c.287T>G	c.(286-288)GTG>GGG	p.V96G	SPOCK1_uc003lbp.2_Missense_Mutation_p.V96G	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	96					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTCACACACACTTTGTGAGG	0.612													5	12					0	0	0	0	C	136476329	C	C	136476329	3	2	295	1	0	0	0	0	1	0	0	0	15145	159	6	5	1064	5	SPOCK1	5	136476329	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	8745403	136476329	44438931	142	54513											
CDHR2	54825	broad.mit.edu	37	chr5	176004720	176004720	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agacattaatgaccacaggcCcacgtttccccagagcttgt	11	9	8	13	1	0	3	0	1	0	2	1	3	1	3	4	1	1	2	4	1	1	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:176004720C>A	uc003mem.1	+	14	1499	c.1433C>A	c.(1432-1434)CCC>CAC	p.P478H	CDHR2_uc003men.1_Missense_Mutation_p.P478H	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	478	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GACCACAGGCCCACGTTTCCC	0.602													16	21					1.15088e-07	1.32588e-07	1	0	A	176004720	A	A	176004720	3	1	295	1	0	0	0	0	1	0	0	0	3134	623	22	4	1483	4	CDHR2	5	176004720	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	39528391	176004720	4910540	143	54514											
NSD1	64324	broad.mit.edu	37	chr5	176638682	176638682	+	Frame_Shift_Del	DEL	G	-	-																															gaggatccccttcagataatGggccacttaacaagtgaaga																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:176638682delG	uc003mfr.3	+	5	3420	c.3282delG	c.(3280-3282)ATGfs	p.M1094fs	NSD1_uc003mft.3_Frame_Shift_Del_p.M825fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.M991fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.M742fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1094					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TTCAGATAATGGGCCACTTAA	0.448			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---								-	176638682	-	-	176638682	7	5	295	1	0	1	0	1	0	0	0	0	10723	1348	47	0	3296	0	NSD1	5	176638682	Frame_Shift_Del	DEL	G	TCGA-F7-7848-01A-11D-2129-08	633962	176638682	4276578	144	54515											
TPMT	7172	broad.mit.edu	37	chr6	18148147	18148147	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaaatgcttctttaatagcCtgaagaggaaaaaaaaaaag	20	9	7	5	0	1	2	0	1	1	1	1	3	1	3	1	1	2	1	1	1	10	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:18148147C>G	uc003ncm.2	-	3	296	c.141_splice	c.e3-1	p.Q47_splice	TPMT_uc010jpm.1_Splice_Site_p.Q47_splice	NM_000367	NP_000358	P51580	TPMT_HUMAN	thiopurine S-methyltransferase						xenobiotic metabolic process	cytosol	thiopurine S-methyltransferase activity				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.146)	all cancers(50;0.06)|Epithelial(50;0.0654)		Mercaptopurine(DB01033)	CTTTAATAGCCTGAAGAGGAA	0.274													29	69					0	0	0	0	G	18148147	G	G	18148147	5	3	295	1	0	0	0	0	0	0	1	0	16476	695	24	4	625	4	TPMT	6	18148147	Splice_Site	SNP	C	TCGA-F7-7848-01A-11D-2129-08		18148147	152966920	145	54516											
HDGFL1	154150	broad.mit.edu	37	chr6	22570038	22570038	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aggcgcggcttcagcgcgggGctgtgggaaatcgagaacaa	10	5	17	9	5	1	1	1	0	0	1	2	3	1	2	0	5	2	2	0	5	3	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:22570038G>T	uc003nds.2	+	1	361	c.234G>T	c.(232-234)GGG>GGT	p.G78G		NM_138574	NP_612641	Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	78											0	Ovarian(93;0.163)					TCAGCGCGGGGCTGTGGGAAA	0.652													10	14					2.17888e-05	2.36398e-05	1	0	T	22570038	T	T	22570038	2	4	295	1	0	0	0	0	0	0	0	1	7058	1190	42	4		4	HDGFL1	6	22570038	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	4421891	22570038	148545029	146	54517											
HIST1H1T	3010	broad.mit.edu	37	chr6	26107876	26107876	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gcttcttggctctcttattgGttttagcagtctttggtgac	4	19	10	8	0	3	1	0	1	3	0	4	1	3	1	0	3	1	4	0	3	2	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:26107876G>T	uc003ngj.2	-	1	489	c.446C>A	c.(445-447)ACC>AAC	p.T149N		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	149					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						TCTCTTATTGGTTTTAGCAGT	0.468													34	85					4.3181e-19	6.03184e-19	1	0	T	26107876	T	T	26107876	3	4	295	1	0	0	0	0	1	0	0	0	7166	1261	44	4	181	4	HIST1H1T	6	26107876	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3537838	26107876	145007191	147	54518											
BTN3A3	10384	broad.mit.edu	37	chr6	26452000	26452000	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagagccgcgggatctgccAgacaaccctgagagatttga	12	6	13	10	2	1	5	0	2	1	3	1	8	1	6	3	1	3	0	3	1	2	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:26452000A>T	uc003nhz.2	+	11	1296	c.1116A>T	c.(1114-1116)CCA>CCT	p.P372P	BTN3A3_uc003nia.2_Silent_p.P330P|BTN3A3_uc011dkn.1_Silent_p.P323P	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	372	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane					0						GGGATCTGCCAGACAACCCTG	0.537													11	50					0	0	0	0	T	26452000	T	T	26452000	2	4	295	1	0	0	0	0	0	0	0	1	1569	175	7	5		5	BTN3A3	6	26452000	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	344124	26452000	144663067	148	54519											
OR2B3	442184	broad.mit.edu	37	chr6	29054757	29054757	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agccagcatagctgatggtcTttttgttgcaaccaatattt	10	15	8	8	0	1	1	0	1	1	0	1	1	1	1	2	1	5	4	2	1	4	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:29054757T>C	uc003nlx.2	-	1	334	c.269A>G	c.(268-270)AAG>AGG	p.K90R		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						GCTGATGGTCTTTTTGTTGCA	0.443													20	73					0	0	0	0	C	29054757	C	C	29054757	3	2	295	1	0	0	0	0	1	0	0	0	11044	1609	56	5	676	5	OR2B3	6	29054757	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	2602757	29054757	142060310	149	54520											
OR12D2	26529	broad.mit.edu	37	chr6	29364491	29364491	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtgatgctgaatacaacCtcagtcaccgaatttctcct	12	11	7	11	1	3	2	2	2	1	0	4	4	3	2	3	0	3	1	3	0	5	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:29364491C>G	uc003nmf.3	+	1	76	c.15C>G	c.(13-15)ACC>ACG	p.T5T		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGAATACAACCTCAGTCACCG	0.428													39	129					0	0	0	0	G	29364491	G	G	29364491	2	3	295	1	0	0	0	0	0	0	0	1	10985	668	24	4		4	OR12D2	6	29364491	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	309734	29364491	141750576	150	54521											
LTA	4049	broad.mit.edu	37	chr6	31540554	31540554	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtctcttcctcccaagggTgtgtggcaccaccctacacc	7	9	8	17	1	1	0	0	0	1	0	4	0	3	0	5	2	1	1	5	2	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:31540554T>G	uc011dnu.1	+	2	248	c.35T>G	c.(34-36)GTG>GGG	p.V12G	LTA_uc003nue.1_Missense_Mutation_p.V12G|LTA_uc003nuf.2_5'Flank|LTA_uc003nuh.2_5'Flank|LTA_uc003nug.2_5'Flank|LTA_uc010jsr.2_5'Flank|TNF_uc003nui.2_5'Flank	NM_001159740	NP_001153212	P01374	TNFB_HUMAN	lymphotoxin alpha precursor	12					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding				0					Etanercept(DB00005)	CTCCCAAGGGTGTGTGGCACC	0.592													35	101					0	0	0	0	G	31540554	G	G	31540554	3	3	295	1	0	0	0	0	1	0	0	0	9118	1696	59	5	37	5	LTA	6	31540554	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	2176063	31540554	139574513	151	54522											
MOCS1	4337	broad.mit.edu	37	chr6	39874378	39874378	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gatgtggctcagggccacgtGgtggcacagagggatcagct	8	7	17	9	1	2	1	2	0	0	1	2	3	2	2	1	5	1	3	1	5	0	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:39874378G>A	uc003opb.2	-	10	1804	c.1666C>T	c.(1666-1668)CAC>TAC	p.H556Y	MOCS1_uc003opa.2_3'UTR|MOCS1_uc003opc.2_Missense_Mutation_p.H540Y|MOCS1_uc003opd.2_3'UTR|MOCS1_uc003ope.2_Missense_Mutation_p.H453Y	NM_005942	NP_005933	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis-step 1 protein	556	Molybdenum cofactor biosynthesis protein C.				Mo-molybdopterin cofactor biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			ovary(1)|liver(1)|central_nervous_system(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					AGGGCCACGTGGTGGCACAGA	0.652													21	79					0	0	0	0	A	39874378	A	A	39874378	3	1	295	1	0	0	0	0	1	0	0	0	9743	1363	47	4		4	MOCS1	6	39874378	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	8333824	39874378	131240689	152	54523											
NCR2	9436	broad.mit.edu	37	chr6	41303865	41303865	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctcaggtacttcaaagtgtGgcagggcagacgctaaccgt	10	8	13	10	2	2	1	2	0	0	1	2	1	2	1	1	3	2	5	1	3	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:41303865G>A	uc003oqh.2	+	2	180	c.93G>A	c.(91-93)GTG>GTA	p.V31V	NCR2_uc003oqi.2_Silent_p.V31V|NCR2_uc003oqj.2_Silent_p.V31V	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	31	Extracellular (Potential).|Ig-like.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					TTCAAAGTGTGGCAGGGCAGA	0.557													21	54					0	0	0	0	A	41303865	A	A	41303865	2	1	295	1	0	0	0	0	0	0	0	1	10292	1335	47	4		4	NCR2	6	41303865	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1429487	41303865	129811202	153	54524											
RHAG	6005	broad.mit.edu	37	chr6	49580244	49580244	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagggtggcattctgaatgtGaacctgtgtgagcggcagaa	11	9	15	6	1	1	4	0	3	1	1	1	4	1	4	1	3	2	2	1	3	4	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:49580244G>T	uc003ozk.3	-	6	873	c.811C>A	c.(811-813)CAC>AAC	p.H271N	RHAG_uc010jzl.2_Missense_Mutation_p.H271N|RHAG_uc010jzm.2_Missense_Mutation_p.H271N	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	271	Helical; (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					TTCTGAATGTGAACCTGTGTG	0.473													12	28					2.27111e-07	2.58976e-07	1	0	T	49580244	T	T	49580244	3	4	295	1	0	0	0	0	1	0	0	0	13380	1290	45	2	438	2	RHAG	6	49580244	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	8276379	49580244	121534823	154	54525											
PKHD1	5314	broad.mit.edu	37	chr6	51768526	51768526	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttccatgtcctgaccagtCtaatgtttcaacaaatccag	12	13	5	11	0	2	1	1	1	1	0	5	1	5	1	4	0	1	1	4	0	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:51768526C>T	uc003pah.1	-	43	7142	c.6866_splice	c.e43-1	p.D2289_splice	PKHD1_uc010jzn.1_Splice_Site_p.D272_splice|PKHD1_uc003pai.2_Splice_Site_p.D2289_splice	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CCTGACCAGTCTAATGTTTCA	0.398													18	50					0	0	0	0	T	51768526	T	T	51768526	5	4	295	1	0	0	0	0	0	0	1	0	12026	927	32	2	5498	2	PKHD1	6	51768526	Splice_Site	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2188282	51768526	119346541	155	54526											
KHDRBS2	202559	broad.mit.edu	37	chr6	62442586	62442586	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tttagatagcaaatgccttaCctttgtgtttgggtcgcata	9	16	9	7	1	0	1	0	0	0	1	1	1	0	1	2	1	3	3	2	1	5	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:62442586C>A	uc003peg.2	-	7	1140	c.893_splice	c.e7+1	p.S298_splice		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		AAATGCCTTACCTTTGTGTTT	0.373													29	50					1.08312e-15	1.45392e-15	1	0	A	62442586	A	A	62442586	5	1	295	1	0	0	0	0	0	0	1	0	8186	521	18	4	167	4	KHDRBS2	6	62442586	Splice_Site	SNP	C	TCGA-F7-7848-01A-11D-2129-08	10674060	62442586	108672481	156	54527											
EYS	346007	broad.mit.edu	37	chr6	66200507	66200507	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaaattgctcatcacatTcacaaatgaaactatttgaa	17	12	4	8	0	3	3	3	3	0	0	3	3	3	3	0	0	2	1	0	0	6	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:66200507T>A	uc011dxu.1	-	5	1380	c.842A>T	c.(841-843)GAA>GTA	p.E281V	EYS_uc003peq.2_Missense_Mutation_p.E281V|EYS_uc003per.1_Missense_Mutation_p.E281V|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	281	EGF-like 3.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CTCATCACATTCACAAATGAA	0.294													8	14					0	0	0	0	A	66200507	A	A	66200507	3	1	295	1	0	0	0	0	1	0	0	0	5357	1783	62	5	8710	5	EYS	6	66200507	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	3757921	66200507	104914560	157	54528											
UBE2CBP	90025	broad.mit.edu	37	chr6	83767585	83767585	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtctgcagtcgcaggtgcagTccatctccaacaacaaactg	11	8	9	13	1	2	0	0	0	2	0	5	0	3	0	2	1	5	3	2	1	3	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:83767585T>G	uc003pjp.2	-	2	342	c.234A>C	c.(232-234)GGA>GGC	p.G78G	UBE2CBP_uc011dyx.1_RNA|UBE2CBP_uc003pjr.2_Silent_p.G46G	NM_198920	NP_944602	Q7Z6J8	UB2CB_HUMAN	ubiquitin-conjugating enzyme E2C binding	78						cytoplasm	ligase activity			ovary(1)	1		all_cancers(76;0.000374)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0548)		BRCA - Breast invasive adenocarcinoma(397;0.0944)		GCAGGTGCAGTCCATCTCCAA	0.463											OREG0017549	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	26					0	0	0	0	G	83767585	G	G	83767585	2	3	295	1	0	0	0	0	0	0	0	1	16915	1654	58	5		5	UBE2CBP	6	83767585	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	17567078	83767585	87347482	158	54529											
BACH2	60468	broad.mit.edu	37	chr6	90660481	90660481	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccaaactgctcaccccagaAtaagaatgcaccgaggtgct	13	7	8	13	1	1	2	1	0	0	2	2	3	2	2	4	1	4	3	4	1	4	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:90660481A>G	uc011eab.1	-	7	2153	c.1344T>C	c.(1342-1344)TAT>TAC	p.Y448Y	BACH2_uc003pnw.2_Silent_p.Y448Y|BACH2_uc010kch.2_Silent_p.Y448Y	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	448						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TCACCCCAGAATAAGAATGCA	0.607													36	60					0	0	0	0	G	90660481	G	G	90660481	2	3	295	1	0	0	0	0	0	0	0	1	1286	108	4	5		5	BACH2	6	90660481	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	6892896	90660481	80454586	159	54530											
FUT9	10690	broad.mit.edu	37	chr6	96651843	96651843	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctctgtacctgttgttctggGaccatctagggaaaactatg	9	13	10	9	0	3	0	0	0	3	0	3	2	3	2	2	2	2	3	2	2	5	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:96651843G>T	uc003pop.3	+	3	1153	c.812G>T	c.(811-813)GGA>GTA	p.G271V		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	271	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GTTGTTCTGGGACCATCTAGG	0.373													5	35					1.23904e-05	1.35416e-05	1	0	T	96651843	T	T	96651843	3	4	295	1	0	0	0	0	1	0	0	0	6145	1174	41	2	814	2	FUT9	6	96651843	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	5991362	96651843	74463224	160	54531											
KLHL32	114792	broad.mit.edu	37	chr6	97512561	97512561	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagcgggcagtcacctacagCtgttggagcttctcaattta	9	11	10	11	1	2	0	2	0	1	0	3	1	2	1	1	2	4	4	1	2	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:97512561C>A	uc010kcm.1	+	5	842	c.370C>A	c.(370-372)CTG>ATG	p.L124M	KLHL32_uc003poy.2_Missense_Mutation_p.L124M|KLHL32_uc011ead.1_Missense_Mutation_p.L88M|KLHL32_uc003poz.2_Translation_Start_Site|KLHL32_uc011eae.1_Intron|KLHL32_uc003ppa.2_RNA	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	124										ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		TCACCTACAGCTGTTGGAGCT	0.443													14	32					4.14922e-12	5.28405e-12	1	0	A	97512561	A	A	97512561	3	1	295	1	0	0	0	0	1	0	0	0	8425	796	28	4	384	4	KLHL32	6	97512561	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	860718	97512561	73602506	161	54532											
COL10A1	1300	broad.mit.edu	37	chr6	116442113	116442113	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gacctggttttcctgggtacCctggttttccatctgaccca	5	14	9	13	0	1	1	0	1	1	0	3	2	3	1	5	3	1	3	5	3	1	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:116442113C>T	uc003pwm.2	-	3	1262	c.1166G>A	c.(1165-1167)GGG>GAG	p.G389E	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	389	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		TCCTGGGTACCCTGGTTTTCC	0.597													15	29					0	0	0	0	T	116442113	T	T	116442113	3	4	295	1	0	0	0	0	1	0	0	0	3681	623	22	4	880	4	COL10A1	6	116442113	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	18929552	116442113	54672954	162	54533											
ROS1	6098	broad.mit.edu	37	chr6	117629982	117629982	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atcaggacaatttcttggtgGctccagtctccctcctgttt	6	15	8	12	0	3	0	1	0	2	0	6	1	5	1	3	3	0	2	3	3	1	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:117629982G>A	uc003pxp.1	-	41	6743	c.6544C>T	c.(6544-6546)CCA>TCA	p.P2182S	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2182	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTTCTTGGTGGCTCCAGTCTC	0.383			T	GOPC|ROS1	glioblastoma|NSCLC								9	40					0	0	0	0	A	117629982	A	A	117629982	3	1	295	1	0	0	0	0	1	0	0	0	13596	1203	42	4	511	4	ROS1	6	117629982	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1187869	117629982	53485085	163	54534											
FAM184A	79632	broad.mit.edu	37	chr6	119337960	119337960	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcattactgtggacagcttcAattgccatatggtgcttcca	9	13	9	10	0	1	0	1	0	0	0	2	1	2	1	2	2	4	3	2	2	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:119337960A>T	uc003pyj.2	-	5	1830	c.1482T>A	c.(1480-1482)ATT>ATA	p.I494I	FAM184A_uc003pyk.3_Silent_p.I374I|FAM184A_uc003pyl.3_Silent_p.I374I	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	494	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						GGACAGCTTCAATTGCCATAT	0.343													22	65					0	0	0	0	T	119337960	T	T	119337960	2	4	295	1	0	0	0	0	0	0	0	1	5539	126	5	5		5	FAM184A	6	119337960	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	1707978	119337960	51777107	164	54535											
LAMA2	3908	broad.mit.edu	37	chr6	129621910	129621910	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttctcatctgggtaataatTgtgacccaaagactgggcga	11	11	11	8	1	2	2	1	1	2	1	3	3	2	2	1	2	0	2	1	2	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:129621910T>A	uc003qbn.2	+	22	3172	c.3067T>A	c.(3067-3069)TGT>AGT	p.C1023S	LAMA2_uc003qbo.2_Missense_Mutation_p.C1023S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1023	Laminin EGF-like 11.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GGGTAATAATTGTGACCCAAA	0.423													20	53					0	0	0	0	A	129621910	A	A	129621910	3	1	295	1	0	0	0	0	1	0	0	0	8646	1812	63	5	3153	5	LAMA2	6	129621910	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	10283950	129621910	41493157	165	54536											
LAMA2	3908	broad.mit.edu	37	chr6	129687473	129687473	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctgcgccatataaaatgctGtatggtcttgaaaatatgac	13	12	8	8	1	1	2	0	2	1	0	1	2	1	2	2	1	2	2	2	1	7	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:129687473G>T	uc003qbn.2	+	33	4932	c.4827G>T	c.(4825-4827)CTG>CTT	p.L1609L	LAMA2_uc003qbo.2_Silent_p.L1609L	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1609	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATAAAATGCTGTATGGTCTTG	0.522													18	27					2.48551e-13	3.25813e-13	1	0	T	129687473	T	T	129687473	2	4	295	1	0	0	0	0	0	0	0	1	8646	1364	48	4		4	LAMA2	6	129687473	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	65563	129687473	41427594	166	54537											
ENPP3	5169	broad.mit.edu	37	chr6	132059244	132059244	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatggagtaaatgtggttagTggaccaatatttgattataa	15	14	10	2	0	0	1	0	1	0	0	0	3	0	3	1	3	0	2	1	3	8	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:132059244T>C	uc003qcu.3	+	24	2588	c.2241T>C	c.(2239-2241)AGT>AGC	p.S747S	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Silent_p.S747S	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	747	Extracellular (Potential).|Nuclease.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		ATGTGGTTAGTGGACCAATAT	0.313													7	23					0	0	0	0	C	132059244	C	C	132059244	2	2	295	1	0	0	0	0	0	0	0	1	5155	1693	59	5		5	ENPP3	6	132059244	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	2371771	132059244	39055823	167	54538											
GRM1	2911	broad.mit.edu	37	chr6	146625950	146625950	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgccttccaggacaccttcTggaaaatcccaactttaaac	12	9	5	15	1	1	0	0	0	1	0	3	2	3	2	5	2	2	0	5	2	5	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:146625950T>C	uc010khw.1	+	4	1624	c.1154T>C	c.(1153-1155)CTG>CCG	p.L385P	GRM1_uc010khv.1_Missense_Mutation_p.L385P|GRM1_uc003qll.2_Missense_Mutation_p.L385P|GRM1_uc011edz.1_Missense_Mutation_p.L385P|GRM1_uc011eea.1_Missense_Mutation_p.L385P	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	385	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGACACCTTCTGGAAAATCCC	0.443													7	40					0	0	0	0	C	146625950	C	C	146625950	3	2	295	1	0	0	0	0	1	0	0	0	6835	1580	55	5	1164	5	GRM1	6	146625950	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	14566706	146625950	24489117	168	54539											
SYNE1	23345	broad.mit.edu	37	chr6	152551704	152551704	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagtctttcagtgcatttTgaacagaagcctgatctcca	11	12	8	10	0	3	3	1	2	2	1	4	4	3	3	2	0	3	1	2	0	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:152551704T>G	uc010kiw.2	-	115	21775	c.21173A>C	c.(21172-21174)CAA>CCA	p.Q7058P	SYNE1_uc010kiv.2_Missense_Mutation_p.Q1582P|SYNE1_uc003qos.3_Missense_Mutation_p.Q1582P|SYNE1_uc003qot.3_Missense_Mutation_p.Q6987P|SYNE1_uc003qou.3_Missense_Mutation_p.Q7058P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7058	Cytoplasmic (Potential).|Spectrin 22.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGTGCATTTTGAACAGAAGC	0.383										HNSCC(10;0.0054)			49	157					0	0	0	0	G	152551704	G	G	152551704	3	3	295	1	0	0	0	0	1	0	0	0	15511	1812	63	5	5421	5	SYNE1	6	152551704	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	5925754	152551704	18563363	169	54540											
SYNE1	23345	broad.mit.edu	37	chr6	152652970	152652970	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	atactttctctcctgcaatgCcaatgctaactttttcaaag	11	15	4	11	0	2	0	1	0	1	0	4	0	3	0	2	0	5	2	2	0	5	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:152652970C>A	uc010kiw.2	-	78	13452	c.12850G>T	c.(12850-12852)GCA>TCA	p.A4284S	SYNE1_uc003qot.3_Missense_Mutation_p.A4213S|SYNE1_uc003qou.3_Missense_Mutation_p.A4284S|SYNE1_uc010kiz.2_Missense_Mutation_p.A39S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4284	Cytoplasmic (Potential).|Spectrin 12.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCCTGCAATGCCAATGCTAAC	0.373										HNSCC(10;0.0054)			24	84					2.39556e-15	3.20604e-15	1	0	A	152652970	A	A	152652970	3	1	295	1	0	0	0	0	1	0	0	0	15511	739	26	4	13892	4	SYNE1	6	152652970	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	101266	152652970	18462097	170	54541											
TCP10L2	401285	broad.mit.edu	37	chr6	167595300	167595300	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggaagtacaggaagaaaaaCgacatccaaatggcaaggca	20	3	11	7	1	0	1	0	0	0	1	1	4	1	3	1	4	2	3	1	4	7	1	rs146018563	by1000genomes	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:167595300C>T	uc010kkp.2	+	8	1089	c.958C>T	c.(958-960)CGA>TGA	p.R320*		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	320											0						GGAAGAAAAACGACATCCAAA	0.527													4	62					0	0	0	0	T	167595300	T	T	167595300	4	4	295	1	0	0	0	0	0	1	0	0	15778	528	19	1	984	1	TCP10L2	6	167595300	Nonsense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	14942330	167595300	3519767	171	54542											
KIAA0415	9907	broad.mit.edu	37	chr7	4825067	4825067	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agccctgaggaagggggactCcgacctgcagaaagctgtaa	12	5	14	10	1	0	2	0	1	0	1	1	5	1	4	3	3	3	3	3	3	3	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:4825067C>A	uc003sne.2	+	8	1036	c.953C>A	c.(952-954)TCC>TAC	p.S318Y	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_5'Flank	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	318					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		AAGGGGGACTCCGACCTGCAG	0.622													14	25					4.7546e-09	5.72859e-09	1	0	A	4825067	A	A	4825067	3	1	295	1	0	0	0	0	1	0	0	0	8214	855	30	2	983	2	KIAA0415	7	4825067	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08		4825067	154313596	172	54543											
ZNF12	7559	broad.mit.edu	37	chr7	6731759	6731759	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaggatttcccacattcacTgcattcatagggcttcattt	10	14	7	10	0	3	0	3	0	0	0	4	2	4	1	1	2	1	2	1	2	2	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:6731759T>A	uc003sqt.1	-	5	1368	c.814A>T	c.(814-816)AGT>TGT	p.S272C	ZNF12_uc011jxa.1_Missense_Mutation_p.S110C|ZNF12_uc003sqs.1_Missense_Mutation_p.S234C	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	272	C2H2-type 1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		CCACATTCACTGCATTCATAG	0.398													13	31					0	0	0	0	A	6731759	A	A	6731759	3	1	295	1	0	0	0	0	1	0	0	0	17785	1580	55	5	1283	5	ZNF12	7	6731759	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	1906692	6731759	152406904	173	54544											
ICA1	3382	broad.mit.edu	37	chr7	8272244	8272244	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcttggcatccaggtccgcGtcagaggcaacaacatgttc	10	8	11	12	2	1	1	1	0	0	1	4	1	3	1	2	3	3	4	2	3	2	2	rs149823604	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:8272244G>A	uc003srm.2	-	3	226	c.159C>T	c.(157-159)GAC>GAT	p.D53D	ICA1_uc010ktr.2_Silent_p.D53D|ICA1_uc003srl.2_Silent_p.D41D|ICA1_uc003srn.3_Translation_Start_Site|ICA1_uc003srp.3_Silent_p.D52D|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Silent_p.D53D|ICA1_uc003srr.2_Silent_p.D52D|ICA1_uc003sro.3_Silent_p.D53D|ICA1_uc011jxg.1_Silent_p.D53D|ICA1_uc003srs.1_Silent_p.D53D	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	53	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		CCAGGTCCGCGTCAGAGGCAA	0.478													3	17					0	0	0	0	A	8272244	A	A	8272244	2	1	295	1	0	0	0	0	0	0	0	1	7516	1136	40	1		1	ICA1	7	8272244	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1540485	8272244	150866419	174	54545											
DNAH11	8701	broad.mit.edu	37	chr7	21627744	21627744	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atggaaattttcagcctacaTtacagcacactagtgcatat	14	12	6	9	0	1	0	1	0	0	0	1	1	1	1	1	1	5	2	1	1	5	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:21627744T>A	uc003svc.2	+	10	1804	c.1773T>A	c.(1771-1773)CAT>CAA	p.H591Q		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	591	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCAGCCTACATTACAGCACAC	0.368									Kartagener_syndrome				8	16					0	0	0	0	A	21627744	A	A	21627744	3	1	295	1	0	0	0	0	1	0	0	0	4621	1490	52	5	1811	5	DNAH11	7	21627744	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	13355500	21627744	137510919	175	54546											
NFE2L3	9603	broad.mit.edu	37	chr7	26225198	26225198	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	taagagagagcaagcacaatGtaacaaagctattaacataa	21	7	7	6	0	0	2	0	0	0	2	0	3	0	2	0	0	5	4	0	0	8	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:26225198G>T	uc003sxq.2	+	4	2152	c.1880G>T	c.(1879-1881)TGT>TTT	p.C627F		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	627	Leucine-zipper.				transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						CAAGCACAATGTAACAAAGCT	0.343													21	66					3.62473e-10	4.46351e-10	1	0	T	26225198	T	T	26225198	3	4	295	1	0	0	0	0	1	0	0	0	10423	1377	48	4	1894	4	NFE2L3	7	26225198	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	4597454	26225198	132913465	176	54547											
BMPER	168667	broad.mit.edu	37	chr7	34118705	34118705	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcagcagcacctcaccgtgCgctggaacggctcgcgcatc	7	6	12	16	5	1	0	1	0	0	0	3	1	1	1	2	2	5	6	2	2	1	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:34118705C>A	uc011kap.1	+	12	1429	c.1315C>A	c.(1315-1317)CGC>AGC	p.R439S		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	439	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						CCTCACCGTGCGCTGGAACGG	0.662													26	52					4.11147e-13	5.37377e-13	1	0	A	34118705	A	A	34118705	3	1	295	1	0	0	0	0	1	0	0	0	1471	768	27	3	1361	3	BMPER	7	34118705	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	7893507	34118705	125019958	177	54548											
ELMO1	9844	broad.mit.edu	37	chr7	37264526	37264526	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccgatggtgatctcctgcGccactttctggtagaggtca	6	11	13	11	2	3	2	1	1	2	1	4	3	3	2	3	4	1	1	3	4	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:37264526G>T	uc003tfk.1	-	9	966	c.659C>A	c.(658-660)GCG>GAG	p.A220E	ELMO1_uc011kbc.1_Missense_Mutation_p.A124E|ELMO1_uc010kxg.1_Missense_Mutation_p.A220E	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	220					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GATCTCCTGCGCCACTTTCTG	0.527													21	42					4.35082e-09	5.2705e-09	1	0	T	37264526	T	T	37264526	3	4	295	1	0	0	0	0	1	0	0	0	5089	1087	38	3	1580	3	ELMO1	7	37264526	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3145821	37264526	121874137	178	54549											
C7orf10	79783	broad.mit.edu	37	chr7	40277269	40277269	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtccaatttctcagcgagctGgttatgatgctgttgcctcg	6	14	11	10	2	1	1	1	1	1	0	4	2	2	1	2	1	4	4	2	1	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:40277269G>T	uc003thn.1	+	7	565	c.520G>T	c.(520-522)GGT>TGT	p.G174C	C7orf10_uc003thm.1_Missense_Mutation_p.G144C|C7orf10_uc003tho.1_Missense_Mutation_p.G174C	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	181							transferase activity			ovary(2)	2						TCAGCGAGCTGGTTATGATGC	0.423													16	65					8.81451e-21	1.25082e-20	1	0	T	40277269	T	T	40277269	3	4	295	1	0	0	0	0	1	0	0	0	2387	1348	47	4	456	4	C7orf10	7	40277269	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3012743	40277269	118861394	179	54550											
ADCY1	107	broad.mit.edu	37	chr7	45614759	45614759	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agccaccttggtccccgccaAgcgcccacgtctctggagga	7	6	11	17	3	1	0	0	0	1	0	3	2	2	2	6	3	2	0	6	3	1	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:45614759A>T	uc003tne.3	+	1	635	c.617A>T	c.(616-618)AAG>ATG	p.K206M	ADCY1_uc003tnd.2_Translation_Start_Site	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	206					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GTCCCCGCCAAGCGCCCACGT	0.662													11	16					0	0	0	0	T	45614759	T	T	45614759	3	4	295	1	0	0	0	0	1	0	0	0	292	72	3	5	619	5	ADCY1	7	45614759	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	5337490	45614759	113523904	180	54551											
AUTS2	26053	broad.mit.edu	37	chr7	70255493	70255493	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ggcagggacttcctgctaagGaacgacccgctccaccggct	8	6	12	15	3	0	0	0	0	0	0	2	3	2	2	4	4	2	4	4	4	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:70255493G>C	uc003tvw.3	+	19	4034	c.3291G>C	c.(3289-3291)AGG>AGC	p.R1097S	AUTS2_uc003tvx.3_Missense_Mutation_p.R1073S|AUTS2_uc011keg.1_Missense_Mutation_p.R549S	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1097										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TCCTGCTAAGGAACGACCCGC	0.577													7	7					0	0	0	0	C	70255493	C	C	70255493	3	2	295	1	0	0	0	0	1	0	0	0	1227	1165	41	2	3510	2	AUTS2	7	70255493	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	24640734	70255493	88883170	181	54552											
PCLO	27445	broad.mit.edu	37	chr7	82546068	82546068	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatccttctcctggaaactGtgcccattgtgctgaatgtg	8	13	10	10	0	1	2	0	1	1	1	3	3	2	3	3	1	3	1	3	1	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:82546068G>T	uc003uhx.2	-	7	11523	c.11234C>A	c.(11233-11235)ACA>AAA	p.T3745K	PCLO_uc003uhv.2_Missense_Mutation_p.T3745K|PCLO_uc010lec.2_Missense_Mutation_p.T710K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3676					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CCTGGAAACTGTGCCCATTGT	0.478													14	41					4.36969e-10	5.36608e-10	1	0	T	82546068	T	T	82546068	3	4	295	1	0	0	0	0	1	0	0	0	11637	1377	48	4	4287	4	PCLO	7	82546068	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	12290575	82546068	76592595	182	54553											
SEMA3E	9723	broad.mit.edu	37	chr7	83021872	83021872	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	atcaggtagcacgtctcaccTttttgcatgtgtgcctgttg	6	15	10	10	1	2	0	2	0	1	0	3	0	2	0	2	1	3	4	2	1	1	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:83021872T>G	uc003uhy.1	-	14	2132	c.1666A>C	c.(1666-1668)AGG>CGG	p.R556R		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	556					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				ACGTCTCACCTTTTTGCATGT	0.438													16	35					0	0	0	0	G	83021872	G	G	83021872	2	3	295	1	0	0	0	0	0	0	0	1	14093	1623	56	5		5	SEMA3E	7	83021872	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	475804	83021872	76116791	183	54554											
ABCB4	5244	broad.mit.edu	37	chr7	87056134	87056134	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttaaggtttttctgagtagAatgcctaaataggcgagatt	12	15	10	4	1	1	3	0	1	1	2	1	4	1	3	1	2	1	2	1	2	6	8			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:87056134A>T	uc003uiv.1	-	16	2072	c.1996T>A	c.(1996-1998)TCT>ACT	p.S666T	ABCB4_uc003uiw.1_Missense_Mutation_p.S666T|ABCB4_uc003uix.1_Missense_Mutation_p.S666T	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	666	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTCTGAGTAGAATGCCTAAAT	0.383													19	31					0	0	0	0	T	87056134	T	T	87056134	3	4	295	1	0	0	0	0	1	0	0	0	43	246	9	5	1916	5	ABCB4	7	87056134	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	4034262	87056134	72082529	184	54555											
SLC25A13	10165	broad.mit.edu	37	chr7	95775870	95775870	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaaaaaaaaagttacctTgtagatcccaaaaaacccca	23	6	3	9	0	0	1	0	0	0	1	1	1	1	1	4	0	2	2	4	0	11	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:95775870T>C	uc003uof.3	-	14	1641	c.1450A>G	c.(1450-1452)AAG>GAG	p.K484E	SLC25A13_uc003uog.3_Missense_Mutation_p.K485E|SLC25A13_uc011kik.1_Missense_Mutation_p.K376E	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	484	Solcar 2.				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	AAAGTTACCTTGTAGATCCCA	0.388													27	71					0	0	0	0	C	95775870	C	C	95775870	3	2	295	1	0	0	0	0	1	0	0	0	14539	1821	63	5	597	5	SLC25A13	7	95775870	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	8719736	95775870	63362793	185	54556											
STAG3	10734	broad.mit.edu	37	chr7	99787212	99787212	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggagagcctgttggagaaacGcaaagaggtgaggagtgttc	12	7	17	5	1	0	4	0	1	0	3	1	7	0	5	1	4	2	3	1	4	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:99787212G>T	uc003utx.1	+	8	1015	c.860G>T	c.(859-861)CGC>CTC	p.R287L	STAG3_uc010lgs.1_Missense_Mutation_p.R75L|STAG3_uc011kjk.1_Missense_Mutation_p.R229L	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	287					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTGGAGAAACGCAAAGAGGTG	0.547													19	101					0.000720815	0.000756348	1	0	T	99787212	T	T	99787212	3	4	295	1	0	0	0	0	1	0	0	0	15310	1087	38	3	886	3	STAG3	7	99787212	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	4011342	99787212	59351451	186	54557											
SRRT	51593	broad.mit.edu	37	chr7	100484691	100484691	+	Frame_Shift_Del	DEL	C	-	-																															ttggacaagctcctcctttaCctgcgcatcgtgcattcctt																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:100484691delC	uc003uwy.2	+	16	2113	c.1845delC	c.(1843-1845)TACfs	p.Y615fs	SRRT_uc010lhl.1_Frame_Shift_Del_p.Y614fs|SRRT_uc003uxa.2_Frame_Shift_Del_p.Y614fs|SRRT_uc003uwz.2_Frame_Shift_Del_p.Y615fs	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	615					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						TCCTCCTTTACCTGCGCATCG	0.602													---	---	---								-	100484691	-	-	100484691	7	5	295	1	0	1	0	1	0	0	0	0	15238	518	18	0	1899	0	SRRT	7	100484691	Frame_Shift_Del	DEL	C	TCGA-F7-7848-01A-11D-2129-08	697479	100484691	58653972	187	54558											
CFTR	1080	broad.mit.edu	37	chr7	117251690	117251690	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaaggactatggacactTcgtgccttcggacggcagcc	10	9	11	11	3	0	0	0	0	0	0	2	3	0	3	2	4	2	1	2	4	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:117251690T>A	uc003vjd.2	+	20	3327	c.3195T>A	c.(3193-3195)CTT>CTA	p.L1065L	CFTR_uc011knq.1_Silent_p.L471L	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	1065	Cytoplasmic (Potential).|ABC transmembrane type-1 2.		L -> R (in CF).|L -> P (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TATGGACACTTCGTGCCTTCG	0.413									Cystic_Fibrosis				6	21					0	0	0	0	A	117251690	A	A	117251690	2	1	295	1	0	0	0	0	0	0	0	1	3309	1770	62	5		5	CFTR	7	117251690	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	16766999	117251690	41886973	188	54559											
KCND2	3751	broad.mit.edu	37	chr7	119915618	119915618	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgccactctcaaggcctgcGcatcctggggtacacactga	8	7	10	16	2	1	1	1	1	1	0	3	1	2	1	4	3	2	2	4	3	2	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:119915618G>A	uc003vjj.1	+	1	1897	c.932G>A	c.(931-933)CGC>CAC	p.R311H		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	311	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					CAAGGCCTGCGCATCCTGGGG	0.507													20	59					0	0	0	0	A	119915618	A	A	119915618	3	1	295	1	0	0	0	0	1	0	0	0	8058	1087	38	1	934	1	KCND2	7	119915618	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2663928	119915618	39223045	189	54560											
DGKI	9162	broad.mit.edu	37	chr7	137308275	137308275	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagccacaatctctttactgTggaaggagaacttttgctgg	10	13	10	8	0	1	1	0	0	1	1	2	3	1	2	1	3	4	1	1	3	5	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:137308275T>C	uc003vtt.2	-	7	831	c.830A>G	c.(829-831)CAC>CGC	p.H277R	DGKI_uc003vtu.2_5'UTR	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	277	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CTCTTTACTGTGGAAGGAGAA	0.443													35	91					0	0	0	0	C	137308275	C	C	137308275	3	2	295	1	0	0	0	0	1	0	0	0	4493	1696	59	5	2479	5	DGKI	7	137308275	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	17392657	137308275	21830388	190	54561											
AKR1D1	6718	broad.mit.edu	37	chr7	137790055	137790055	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggacatttactctacaggcGatggaagcttgcaaagacgc	12	9	11	9	2	1	1	0	0	1	1	1	4	1	3	0	3	4	2	0	3	4	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:137790055G>T	uc003vtz.2	+	5	528	c.459G>T	c.(457-459)GCG>GCT	p.A153A	AKR1D1_uc011kqb.1_Silent_p.A153A|AKR1D1_uc011kqc.1_RNA|AKR1D1_uc011kqd.1_RNA|AKR1D1_uc011kqe.1_Silent_p.A153A|AKR1D1_uc011kqf.1_Intron|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	153					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						CTCTACAGGCGATGGAAGCTT	0.453													47	135					1.35964e-18	1.88745e-18	1	0	T	137790055	T	T	137790055	2	4	295	1	0	0	0	0	0	0	0	1	473	1045	37	3		3	AKR1D1	7	137790055	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	481780	137790055	21348608	191	54562											
TAS2R40	259286	broad.mit.edu	37	chr7	142919874	142919874	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagcaatgccacagggtccAgggaccccagcatgaaggct	12	4	13	12	0	0	1	0	1	0	0	1	3	1	2	4	3	3	3	4	3	3	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:142919874A>T	uc011ksx.1	+	1	703	c.703A>T	c.(703-705)AGG>TGG	p.R235W		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	235	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					CACAGGGTCCAGGGACCCCAG	0.507													28	76					0	0	0	0	T	142919874	T	T	142919874	3	4	295	1	0	0	0	0	1	0	0	0	15644	179	7	5	705	5	TAS2R40	7	142919874	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	5129819	142919874	16218789	192	54563											
SSPO	23145	broad.mit.edu	37	chr7	149517793	149517793	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgccaaccgctgcccccGccgctgctcagacctccagg	5	6	10	20	3	1	1	1	0	0	1	2	1	2	1	7	1	4	3	7	1	1	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:149517793G>C	uc010lpk.2	+	87	12230	c.12230G>C	c.(12229-12231)CGC>CCC	p.R4077P	SSPO_uc010lpm.1_5'Flank|SSPO_uc003wgg.2_5'Flank|SSPO_uc003wgh.2_5'Flank|SSPO_uc003wgi.1_5'Flank	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4077					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGCTGCCCCCGCCGCTGCTCA	0.657													4	17					0	0	0	0	C	149517793	C	C	149517793	3	2	295	1	0	0	0	0	1	0	0	0	15255	1087	38	3	12566	3	SSPO	7	149517793	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	6597919	149517793	9620870	193	54564											
AGAP3	116988	broad.mit.edu	37	chr7	150814821	150814821	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttcctgcgtctctgcagcttCcgcaacgccagcgaggtgcc	5	9	11	16	4	1	0	0	0	1	0	4	1	3	0	4	1	6	3	4	1	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:150814821C>T	uc003wjg.1	+	5	666	c.663C>T	c.(661-663)TTC>TTT	p.F221F	AGAP3_uc003wje.1_5'UTR|AGAP3_uc003wjf.1_Silent_p.F221F|AGAP3_uc010lpy.1_Silent_p.F221F|AGAP3_uc003wjh.1_Silent_p.F401F	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	185	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						TCTGCAGCTTCCGCAACGCCA	0.602													39	88					0	0	0	0	T	150814821	T	T	150814821	2	4	295	1	0	0	0	0	0	0	0	1	369	854	30	2		2	AGAP3	7	150814821	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	1297028	150814821	8323842	194	54565											
SOX7	83595	broad.mit.edu	37	chr8	10583720	10583720	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcaggtgggggatgcggCggggatggccatgctcctcc	4	7	19	11	2	0	0	0	0	0	0	2	2	2	2	3	8	2	2	3	8	0	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:10583720C>T	uc003wtf.2	-	2	774	c.695G>A	c.(694-696)CGC>CAC	p.R232H	SOX7_uc011kwz.1_Missense_Mutation_p.R284H	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	232					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GGGGATGCGGCGGGGATGGCC	0.682													17	14					0	0	0	0	T	10583720	T	T	10583720	3	4	295	1	0	0	0	0	1	0	0	0	15020	768	27	1	475	1	SOX7	8	10583720	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08		10583720	135780302	195	54566											
MTMR7	9108	broad.mit.edu	37	chr8	17206577	17206577	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gaacgtacagttcagtaggaTaagagtcacagacctgtcac	14	8	10	9	1	3	2	3	0	0	2	3	4	3	3	1	1	2	3	1	1	4	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:17206577T>C	uc003wxm.2	-	5	721	c.482A>G	c.(481-483)TAT>TGT	p.Y161C	MTMR7_uc003wxn.2_5'UTR	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	161	Myotubularin phosphatase.						protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		TTCAGTAGGATAAGAGTCACA	0.473													16	46					0	0	0	0	C	17206577	C	C	17206577	3	2	295	1	0	0	0	0	1	0	0	0	10001	1406	49	5	1540	5	MTMR7	8	17206577	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	6622857	17206577	129157445	196	54567											
NAT1	9	broad.mit.edu	37	chr8	18079810	18079810	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgaccactattggttttgAgaccacgatgttgggagggt	8	13	13	7	1	1	2	0	2	1	1	1	5	1	3	2	3	0	2	2	3	1	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:18079810A>T	uc010ltd.2	+	5	621	c.254A>T	c.(253-255)GAG>GTG	p.E85V	NAT1_uc003wyt.2_Missense_Mutation_p.E147V|NAT1_uc003wyu.2_Missense_Mutation_p.E85V|NAT1_uc003wyv.2_Missense_Mutation_p.E85V|NAT1_uc010ltc.2_Missense_Mutation_p.E85V|NAT1_uc003wys.2_Missense_Mutation_p.E147V|NAT1_uc003wyr.2_Missense_Mutation_p.E85V|NAT1_uc003wyq.2_Missense_Mutation_p.E85V|NAT1_uc011kyl.1_Missense_Mutation_p.E85V	NM_001160179	NP_001153651	P18440	ARY1_HUMAN	N-acetyltransferase 1 isoform a	85					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity				0				Colorectal(111;0.0519)|COAD - Colon adenocarcinoma(73;0.208)		ATTGGTTTTGAGACCACGATG	0.473													39	53					0	0	0	0	T	18079810	T	T	18079810	3	4	295	1	0	0	0	0	1	0	0	0	10226	304	11	5	450	5	NAT1	8	18079810	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	873233	18079810	128284212	197	54568											
KIF13B	23303	broad.mit.edu	37	chr8	29006204	29006204	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtctacatccagctgctcaGaactattctcgttcttcatg	8	14	6	13	2	5	1	2	0	3	1	7	1	6	1	1	0	4	3	1	0	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:29006204G>A	uc003xhh.3	-	16	1762	c.1703C>T	c.(1702-1704)TCT>TTT	p.S568F	KIF13B_uc003xhj.2_Missense_Mutation_p.S465F|KIF13B_uc010lvf.1_Missense_Mutation_p.S504F	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	568					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CAGCTGCTCAGAACTATTCTC	0.463													26	52					0	0	0	0	A	29006204	A	A	29006204	3	1	295	1	0	0	0	0	1	0	0	0	8314	942	33	2	3877	2	KIF13B	8	29006204	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	10926394	29006204	117357818	198	54569											
OPRK1	4986	broad.mit.edu	37	chr8	54147356	54147356	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccaaggactattgcagaGatgccaacagatgacgacag	14	6	10	11	1	0	3	0	1	0	2	1	6	1	4	3	1	3	1	3	1	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:54147356G>T	uc003xrh.1	-	2	948	c.573C>A	c.(571-573)ATC>ATA	p.I191I	OPRK1_uc003xri.1_Silent_p.I191I|OPRK1_uc010lyc.1_Silent_p.I102I	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	191	Helical; Name=4; (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CTATTGCAGAGATGCCAACAG	0.448													18	83					6.49762e-13	8.44313e-13	1	0	T	54147356	T	T	54147356	2	4	295	1	0	0	0	0	0	0	0	1	10939	932	33	2		2	OPRK1	8	54147356	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	25141152	54147356	92216666	199	54570											
CHD7	55636	broad.mit.edu	37	chr8	61765575	61765575	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgggagtgtggacggcatgaCcgagacttgctggttggtgc	6	10	18	7	2	0	2	0	1	0	1	0	5	0	4	1	5	2	3	1	5	0	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:61765575C>T	uc003xue.2	+	31	6768	c.6291C>T	c.(6289-6291)GAC>GAT	p.D2097D		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2097					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GACGGCATGACCGAGACTTGC	0.547													16	20					0	0	0	0	T	61765575	T	T	61765575	2	4	295	1	0	0	0	0	0	0	0	1	3345	506	18	4		4	CHD7	8	61765575	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	7618219	61765575	84598447	200	54571											
SULF1	23213	broad.mit.edu	37	chr8	70512983	70512983	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtcagtggatgattctgtgGagagggtaagcacatgaacc	11	10	14	6	0	2	3	1	2	1	1	2	5	2	4	1	3	2	2	1	3	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:70512983G>T	uc010lza.1	+	9	1597	c.880G>T	c.(880-882)GAG>TAG	p.E294*	SULF1_uc003xyd.2_Nonsense_Mutation_p.E294*|SULF1_uc003xye.2_Nonsense_Mutation_p.E294*|SULF1_uc003xyf.2_Nonsense_Mutation_p.E294*|SULF1_uc003xyg.2_Nonsense_Mutation_p.E294*|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	294					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TGATTCTGTGGAGAGGGTAAG	0.443													31	118					2.47316e-13	3.25148e-13	1	0	T	70512983	T	T	70512983	4	4	295	1	0	0	0	0	0	1	0	0	15436	1175	41	2	898	2	SULF1	8	70512983	Nonsense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	8747408	70512983	75851039	201	54572											
ZFHX4	79776	broad.mit.edu	37	chr8	77764098	77764098	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatgtcaacagccctggccaGgggatgttagattccatgag	11	9	12	9	0	1	2	1	1	0	1	2	3	2	3	3	3	2	1	3	3	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:77764098G>A	uc003yav.2	+	10	5193	c.4806G>A	c.(4804-4806)CAG>CAA	p.Q1602Q	ZFHX4_uc003yau.1_Silent_p.Q1647Q|ZFHX4_uc003yaw.1_Silent_p.Q1602Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1602						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCCTGGCCAGGGGATGTTAG	0.473										HNSCC(33;0.089)			12	50					0	0	0	0	A	77764098	A	A	77764098	2	1	295	1	0	0	0	0	0	0	0	1	17702	991	35	4		4	ZFHX4	8	77764098	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	7251115	77764098	68599924	202	54573											
IMPA1	3612	broad.mit.edu	37	chr8	82591364	82591364	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacattttaaaacatacctaTgtacaaagttagttgttcca	15	14	5	7	0	0	0	0	0	0	0	1	1	1	0	2	0	3	4	2	0	7	8			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:82591364T>C	uc003ych.2	-	4	426	c.299A>G	c.(298-300)CAT>CGT	p.H100R	IMPA1_uc011lfq.1_Missense_Mutation_p.H159R|IMPA1_uc011lfr.1_Missense_Mutation_p.H100R	NM_005536	NP_005527	P29218	IMPA1_HUMAN	inositol(myo)-1(or 4)-monophosphatase 1 isoform	100					inositol phosphate dephosphorylation|phosphatidylinositol biosynthetic process|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(1)	1					Lithium(DB01356)	AACATACCTATGTACAAAGTT	0.338													25	32					0	0	0	0	C	82591364	C	C	82591364	3	2	295	1	0	0	0	0	1	0	0	0	7761	1464	51	5	558	5	IMPA1	8	82591364	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	4827266	82591364	63772658	203	54574											
CA3	761	broad.mit.edu	37	chr8	86351946	86351946	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gactttatttcctaggtcctGaccactggcatgaacttttc	8	15	7	11	0	0	2	0	2	0	0	3	3	2	2	3	2	1	1	3	2	3	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:86351946G>T	uc003ydj.2	+	2	123	c.40G>T	c.(40-42)GAC>TAC	p.D14Y	CA13_uc003ydf.1_RNA|CA3_uc011lfv.1_RNA	NM_005181	NP_005172	P07451	CAH3_HUMAN	carbonic anhydrase III	14					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0						CCTAGGTCCTGACCACTGGCA	0.473													8	68					7.48243e-07	8.40363e-07	1	0	T	86351946	T	T	86351946	3	4	295	1	0	0	0	0	1	0	0	0	2529	1290	45	2	46	2	CA3	8	86351946	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3760582	86351946	60012076	204	54575											
RUNX1T1	862	broad.mit.edu	37	chr8	92998530	92998530	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcgccttgttttttctacCatgtccattatgcagtttaa	8	18	6	9	1	1	0	0	0	1	0	3	1	2	0	3	0	2	3	3	0	3	8			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:92998530C>A	uc003yfd.2	-	8	1185	c.1101G>T	c.(1099-1101)ATG>ATT	p.M367I	RUNX1T1_uc003yfc.1_Missense_Mutation_p.M340I|RUNX1T1_uc003yfe.1_Missense_Mutation_p.M330I|RUNX1T1_uc010mao.2_Missense_Mutation_p.M340I|RUNX1T1_uc011lgi.1_Missense_Mutation_p.M378I|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Missense_Mutation_p.M330I	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	367	Important for oligomerization.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTTTTTCTACCATGTCCATTA	0.438													38	71					1.47244e-24	2.13004e-24	1	0	A	92998530	A	A	92998530	3	1	295	1	0	0	0	0	1	0	0	0	13812	594	21	4	729	4	RUNX1T1	8	92998530	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	6646584	92998530	53365492	205	54576											
PTDSS1	9791	broad.mit.edu	37	chr8	97321822	97321822	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tcaccgacacacagtgcaagCgcgtaggaacacaatgctgg	13	5	11	12	3	1	0	1	0	0	0	1	2	1	1	1	2	4	3	1	2	4	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:97321822C>T	uc003yht.1	+	9	1147	c.1045C>T	c.(1045-1047)CGC>TGC	p.R349C	PTDSS1_uc003yhu.1_Missense_Mutation_p.R203C	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	349					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	ACAGTGCAAGCGCGTAGGAAC	0.423													13	43					0	0	0	0	T	97321822	T	T	97321822	3	4	295	1	0	0	0	0	1	0	0	0	12798	768	27	1	1079	1	PTDSS1	8	97321822	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	4323292	97321822	49042200	206	54577											
UBR5	51366	broad.mit.edu	37	chr8	103326146	103326146	+	Splice_Site	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggggttgaccgtcgtcgttcTtagacaacaacaaaatggta	12	10	11	8	3	1	2	0	1	1	1	3	2	1	2	1	3	2	3	1	3	6	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:103326146T>C	uc003ykr.1	-	16	1928	c.1895_splice	c.e16-1	p.K632_splice	UBR5_uc003yks.1_Splice_Site_p.K632_splice	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin						cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GTCGTCGTTCTTAGACAACAA	0.363													14	100					0	0	0	0	C	103326146	C	C	103326146	5	2	295	1	0	0	0	0	0	0	1	0	16973	1623	56	5	6682	5	UBR5	8	103326146	Splice_Site	SNP	T	TCGA-F7-7848-01A-11D-2129-08	6004324	103326146	43037876	207	54578											
CSMD3	114788	broad.mit.edu	37	chr8	113256715	113256715	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	agaagaagccaggctgacagGtataaatcagtgtataccca	16	7	10	8	0	1	3	1	1	0	2	1	3	1	3	2	2	2	3	2	2	7	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:113256715G>A	uc003ynu.2	-	65	10469	c.10310C>T	c.(10309-10311)ACC>ATC	p.T3437I	CSMD3_uc003yns.2_Missense_Mutation_p.T2639I|CSMD3_uc003ynt.2_Missense_Mutation_p.T3397I|CSMD3_uc011lhx.1_Missense_Mutation_p.T3268I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3437	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGGCTGACAGGTATAAATCAG	0.438										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	61					0	0	0	0	A	113256715	A	A	113256715	3	1	295	1	0	0	0	0	1	0	0	0	3963	1261	44	4	841	4	CSMD3	8	113256715	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	9930569	113256715	33107307	208	54579											
CSMD3	114788	broad.mit.edu	37	chr8	113318355	113318355	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	aaaaataggtaactcgcgttCctaccaaatagtctgttgtt	13	13	7	8	2	1	0	0	0	1	0	3	0	2	0	2	1	2	4	2	1	7	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:113318355C>G	uc003ynu.2	-	51	8111	c.7952G>C	c.(7951-7953)GGA>GCA	p.G2651A	CSMD3_uc003yns.2_Missense_Mutation_p.G1853A|CSMD3_uc003ynt.2_Missense_Mutation_p.G2611A|CSMD3_uc011lhx.1_Missense_Mutation_p.G2547A	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2651	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AACTCGCGTTCCTACCAAATA	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	53					0	0	0	0	G	113318355	G	G	113318355	3	3	295	1	0	0	0	0	1	0	0	0	3963	855	30	2	3255	2	CSMD3	8	113318355	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	61640	113318355	33045667	209	54580											
CSMD3	114788	broad.mit.edu	37	chr8	113569034	113569034	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccatgcccttctctcccCtgtcatgcacttgagaaggc	6	11	8	16	0	2	1	1	1	1	1	5	2	4	1	4	1	2	1	4	1	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:113569034C>A	uc003ynu.2	-	25	4351	c.4192G>T	c.(4192-4194)GGG>TGG	p.G1398W	CSMD3_uc003yns.2_Missense_Mutation_p.G670W|CSMD3_uc003ynt.2_Missense_Mutation_p.G1358W|CSMD3_uc011lhx.1_Missense_Mutation_p.G1294W	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1398	Extracellular (Potential).|Sushi 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTCTCTCCCCTGTCATGCAC	0.438										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	57					0.00010058	0.000108335	1	0	A	113569034	A	A	113569034	3	1	295	1	0	0	0	0	1	0	0	0	3963	681	24	4	7119	4	CSMD3	8	113569034	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	250679	113569034	32794988	210	54581											
UTP23	84294	broad.mit.edu	37	chr8	117782554	117782554	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgagtggatcagaatgtctGctttccatggttgaagaggg	9	12	15	5	0	2	4	1	2	1	2	3	5	3	5	1	3	1	2	1	3	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:117782554G>T	uc003yoc.2	+	2	413	c.312G>T	c.(310-312)CTG>CTT	p.L104L		NM_032334	NP_115710	Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component,	104					rRNA processing	nucleolus					0						CAGAATGTCTGCTTTCCATGG	0.378													63	94					6.2918e-36	9.28196e-36	1	0	T	117782554	T	T	117782554	2	4	295	1	0	0	0	0	0	0	0	1	17168	1306	46	4		4	UTP23	8	117782554	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	4213520	117782554	28581468	211	54582											
ADCY8	114	broad.mit.edu	37	chr8	132051742	132051742	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggcagcatactgtaggtggCgaagagcgtgaagagcacgt	11	6	16	8	4	0	3	0	1	0	2	0	4	0	3	0	3	4	4	0	3	4	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:132051742C>A	uc003ytd.3	-	1	1094	c.838G>T	c.(838-840)GCC>TCC	p.A280S	ADCY8_uc010mds.2_Missense_Mutation_p.A280S	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	280	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTGTAGGTGGCGAAGAGCGTG	0.667										HNSCC(32;0.087)			15	54					1.52009e-12	1.95816e-12	1	0	A	132051742	A	A	132051742	3	1	295	1	0	0	0	0	1	0	0	0	300	768	27	3	2989	3	ADCY8	8	132051742	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	14269188	132051742	14312280	212	54583											
SLA	6503	broad.mit.edu	37	chr8	134057291	134057291	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctcggggaaatgtagtacCagttgttgggcagacggaaa	11	8	15	7	2	0	1	0	0	0	1	1	3	0	3	2	4	1	5	2	4	4	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:134057291C>A	uc003ytz.2	-	7	1254	c.422G>T	c.(421-423)TGG>TTG	p.W141L	TG_uc003ytw.2_Intron|TG_uc010mdw.2_Intron|TG_uc011ljb.1_Intron|TG_uc011ljc.1_Intron|SLA_uc011lje.1_Missense_Mutation_p.W158L|SLA_uc011ljf.1_Missense_Mutation_p.W33L|SLA_uc011ljg.1_Intron|SLA_uc011ljd.1_Missense_Mutation_p.W181L	NM_001045556	NP_001039021	Q13239	SLAP1_HUMAN	Src-like-adaptor isoform a	141	SH2.					endosome	SH3/SH2 adaptor activity			lung(1)|liver(1)	2	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			AATGTAGTACCAGTTGTTGGG	0.512													16	68					1.5739e-10	1.96517e-10	1	0	A	134057291	A	A	134057291	3	1	295	1	0	0	0	0	1	0	0	0	14428	595	21	4	420	4	SLA	8	134057291	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2005549	134057291	12306731	213	54584											
C8orf31	286122	broad.mit.edu	37	chr8	144130634	144130634	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttgtcattgcaggattctctCggcaccacgggaaccacctt	8	11	9	13	2	2	0	1	0	1	0	4	2	2	2	3	3	2	2	3	3	1	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:144130634C>G	uc003yxp.1	+	5	716	c.364C>G	c.(364-366)CGG>GGG	p.R122G	C8orf31_uc003yxq.1_RNA|C8orf31_uc003yxr.1_RNA	NM_173687	NP_775958	Q8N9H6	CH031_HUMAN	hypothetical protein LOC286122	122										ovary(1)	1	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					aggattctctcggcaccacgg	0.02													49	75					0	0	0	0	G	144130634	G	G	144130634	3	3	295	1	0	0	0	0	1	0	0	0	2432	875	31	3	378	3	C8orf31	8	144130634	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	10073343	144130634	2233388	214	54585											
NRBP2	340371	broad.mit.edu	37	chr8	144921093	144921093	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaaggagaagatgtccacagCggtcccatcggccacctctg	11	6	11	13	2	1	2	0	0	1	2	4	3	3	2	4	3	1	0	4	3	2	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:144921093C>T	uc011lkt.1	-	9	846	c.706G>A	c.(706-708)GCT>ACT	p.A236T	NRBP2_uc003yzv.2_5'UTR|NRBP2_uc003yzz.1_5'Flank|NRBP2_uc003yzw.2_5'Flank|NRBP2_uc010mfl.2_5'Flank|NRBP2_uc010mfm.2_5'UTR|NRBP2_uc011lks.1_5'UTR|NRBP2_uc003yzy.2_5'UTR	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	236	Protein kinase.				negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			ATGTCCACAGCGGTCCCATCG	0.632													10	24					0	0	0	0	T	144921093	T	T	144921093	3	4	295	1	0	0	0	0	1	0	0	0	10697	768	27	1	839	1	NRBP2	8	144921093	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	790459	144921093	1442929	215	54586											
PTPRD	5789	broad.mit.edu	37	chr9	8636759	8636759	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagacaattttaggtcttggGtctcccgtagcttggcagat	8	13	11	9	1	2	2	0	0	2	2	3	2	2	2	1	3	1	3	1	3	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:8636759G>T	uc003zkk.2	-	12	861	c.150C>A	c.(148-150)GAC>GAA	p.D50E	PTPRD_uc003zkp.2_Missense_Mutation_p.D50E|PTPRD_uc003zkq.2_Missense_Mutation_p.D50E|PTPRD_uc003zkr.2_Missense_Mutation_p.D50E|PTPRD_uc003zks.2_Missense_Mutation_p.D50E|PTPRD_uc003zkl.2_Missense_Mutation_p.D50E|PTPRD_uc003zkm.2_Missense_Mutation_p.D50E|PTPRD_uc003zkn.2_Missense_Mutation_p.D50E|PTPRD_uc003zko.2_Missense_Mutation_p.D50E|PTPRD_uc003zkt.1_Missense_Mutation_p.D50E	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	50	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TAGGTCTTGGGTCTCCCGTAG	0.443										TSP Lung(15;0.13)			12	47					5.50884e-06	6.05025e-06	1	0	T	8636759	T	T	8636759	3	4	295	1	0	0	0	0	1	0	0	0	12864	1252	44	4	5792	4	PTPRD	9	8636759	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08		8636759	132576672	216	54587											
C9orf82	79886	broad.mit.edu	37	chr9	26861107	26861107	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggttgcttattctctctcacGgatgaagcagaatctataca	11	13	8	9	1	3	2	1	1	3	1	5	3	3	3	0	2	3	3	0	2	5	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:26861107G>A	uc003zqc.2	-	5	708	c.696C>T	c.(694-696)TCC>TCT	p.S232S	C9orf82_uc003zqb.2_Silent_p.S87S	NM_024828	NP_079104	Q9H8G2	CI082_HUMAN	hypothetical protein LOC79886	232											0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(42;1.39e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		TCTCTCTCACGGATGAAGCAG	0.323													35	45					0	0	0	0	A	26861107	A	A	26861107	2	1	295	1	0	0	0	0	0	0	0	1	2511	1103	39	1		1	C9orf82	9	26861107	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	18224348	26861107	114352324	217	54588											
CEP78	84131	broad.mit.edu	37	chr9	80880327	80880327	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggctgggatagatcagtcAgattttcaattactaggtca	12	13	10	6	0	4	2	4	0	0	2	4	3	4	3	0	3	1	1	0	3	4	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:80880327A>C	uc004akx.2	+	14	1941	c.1665A>C	c.(1663-1665)TCA>TCC	p.S555S	CEP78_uc004aky.3_Silent_p.S556S|CEP78_uc010mpp.2_Silent_p.S556S|CEP78_uc004akz.1_Silent_p.S43S	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	555					G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1						TAGATCAGTCAGATTTTCAAT	0.438													2	2					0	0	0	0	C	80880327	C	C	80880327	2	2	295	1	0	0	0	0	0	0	0	1	3277	175	7	5		5	CEP78	9	80880327	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	54019220	80880327	60333104	218	54589											
INVS	27130	broad.mit.edu	37	chr9	103002466	103002466	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gacctcatatgaaagctgcaAtataacgtcttatgataact	15	12	6	8	1	2	2	1	2	1	0	2	3	2	2	1	0	4	2	1	0	7	5	rs41312220	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:103002466A>G	uc004bap.1	+	6	952	c.740A>G	c.(739-741)AAT>AGT	p.N247S	INVS_uc010mta.1_Missense_Mutation_p.N151S|INVS_uc011lve.1_Missense_Mutation_p.N151S|INVS_uc004bao.1_Missense_Mutation_p.N247S|INVS_uc004baq.1_Missense_Mutation_p.N151S|INVS_uc004bar.1_Missense_Mutation_p.N151S|INVS_uc010mtb.1_5'UTR	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	247	ANK 7.				negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)				GAAAGCTGCAATATAACGTCT	0.438													4	59					0	0	0	0	G	103002466	G	G	103002466	3	3	295	1	0	0	0	0	1	0	0	0	7826	101	4	5	758	5	INVS	9	103002466	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	22122139	103002466	38210965	219	54590											
EPB41L4B	54566	broad.mit.edu	37	chr9	111970306	111970306	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtggagtctgaagagttttCtccgagactttcttttcttc	7	17	9	8	1	4	3	0	1	4	2	6	5	4	4	1	1	0	1	1	1	1	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:111970306C>T	uc004bdz.1	-	18	2071	c.1776G>A	c.(1774-1776)GAG>GAA	p.E592E		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	592						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						GAAGAGTTTTCTCCGAGACTT	0.413													18	39					0	0	0	0	T	111970306	T	T	111970306	2	4	295	1	0	0	0	0	0	0	0	1	5180	912	32	2		2	EPB41L4B	9	111970306	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	8967840	111970306	29243125	220	54591											
MUSK	4593	broad.mit.edu	37	chr9	113562629	113562629	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atgtgcctgctctttgaataCatggcctatggtgacctcaa	9	13	9	10	0	2	2	1	2	1	0	2	2	2	2	3	2	3	1	3	2	4	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:113562629C>A	uc004bey.2	+	14	2069	c.1971C>A	c.(1969-1971)TAC>TAA	p.Y657*	MUSK_uc004bez.1_Nonsense_Mutation_p.Y237*	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	657	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						TCTTTGAATACATGGCCTATG	0.507													31	45					8.88839e-20	1.24941e-19	1	0	A	113562629	A	A	113562629	4	1	295	1	0	0	0	0	0	1	0	0	10042	489	17	4	2061	4	MUSK	9	113562629	Nonsense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	1592323	113562629	27650802	221	54592											
PTGS1	5742	broad.mit.edu	37	chr9	125145892	125145892	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagatggctgtgggccaggaGgtgtttgggctgcttcctgg	4	11	18	8	0	0	1	0	0	0	1	1	2	1	2	2	6	1	4	2	6	0	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:125145892G>T	uc004bmg.1	+	8	1002	c.867G>T	c.(865-867)GAG>GAT	p.E289D	PTGS1_uc011lys.1_Missense_Mutation_p.E264D|PTGS1_uc010mwb.1_Missense_Mutation_p.E180D|PTGS1_uc004bmf.1_Missense_Mutation_p.E289D|PTGS1_uc004bmh.1_Missense_Mutation_p.E180D|PTGS1_uc011lyt.1_Missense_Mutation_p.E180D	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	289					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TGGGCCAGGAGGTGTTTGGGC	0.622													18	43					2.94398e-08	3.42698e-08	1	0	T	125145892	T	T	125145892	3	4	295	1	0	0	0	0	1	0	0	0	12818	991	35	4	897	4	PTGS1	9	125145892	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	11583263	125145892	16067539	222	54593											
GBGT1	26301	broad.mit.edu	37	chr9	136029278	136029278	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaggcagtggaaacacgccTgcgctcataggggaactgct	12	6	13	10	2	1	0	1	0	0	0	1	2	1	2	1	4	4	3	1	4	4	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:136029278T>A	uc004ccw.2	-	7	1011	c.730A>T	c.(730-732)AGG>TGG	p.R244W	RALGDS_uc011mcw.1_Intron|GBGT1_uc004ccx.2_Missense_Mutation_p.R197W|GBGT1_uc010nab.2_3'UTR|GBGT1_uc011mcx.1_Missense_Mutation_p.R227W|GBGT1_uc010nac.1_Missense_Mutation_p.R108W|GBGT1_uc004ccy.1_3'UTR	NM_021996	NP_068836	Q8N5D6	GBGT1_HUMAN	globoside	244	Lumenal (Potential).				carbohydrate metabolic process|glycolipid biosynthetic process	Golgi membrane|integral to membrane	metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;3.49e-06)|Epithelial(140;2.59e-05)		GAAACACGCCTGCGCTCATAG	0.597													32	56					0	0	0	0	A	136029278	A	A	136029278	3	1	295	1	0	0	0	0	1	0	0	0	6307	1579	55	5	317	5	GBGT1	9	136029278	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	10883386	136029278	5184153	223	54594											
CACNA1B	774	broad.mit.edu	37	chr9	140772650	140772650	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtcgtccgcaaatacgcgAagcgcatcaccgagtggcca	11	5	11	14	7	1	0	1	0	0	0	3	2	2	0	3	1	2	2	3	1	3	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:140772650A>G	uc004cog.2	+	1	410	c.265A>G	c.(265-267)AAG>GAG	p.K89E	uc004cof.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	89	Cytoplasmic (Potential).|I.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CAAATACGCGAAGCGCATCAC	0.423													4	9					0	0	0	0	G	140772650	G	G	140772650	3	3	295	1	0	0	0	0	1	0	0	0	2551	247	9	5	267	5	CACNA1B	9	140772650	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	4743372	140772650	440781	224	54595											
FAM188A	80013	broad.mit.edu	37	chr10	15838171	15838171	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	aggggcaactaaagccatatCctgaaaagataagaagcatg	18	6	10	7	0	0	3	0	1	0	2	1	3	1	3	2	2	3	2	2	2	8	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:15838171C>A	uc001iod.1	-	11	1104	c.883G>T	c.(883-885)GAT>TAT	p.D295Y	FAM188A_uc001ioe.1_Missense_Mutation_p.D122Y|FAM188A_uc001iof.1_Missense_Mutation_p.D295Y	NM_024948	NP_079224	Q9H8M7	F188A_HUMAN	chromosome 10 open reading frame 97	295					apoptosis	nucleus	calcium ion binding			ovary(1)	1						AAAGCCATATCCTGAAAAGAT	0.353													32	98					2.68265e-12	3.43594e-12	1	0	A	15838171	A	A	15838171	3	1	295	1	0	0	0	0	1	0	0	0	5542	869	30	2	474	2	FAM188A	10	15838171	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08		15838171	119696576	225	54596											
CUBN	8029	broad.mit.edu	37	chr10	16982125	16982125	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaacgatggaagaataattGagagggaaggagtttccaca	16	7	12	6	1	0	2	0	1	0	2	1	7	1	5	2	3	1	1	2	3	5	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:16982125G>A	uc001ioo.2	-	37	5506	c.5454C>T	c.(5452-5454)CTC>CTT	p.L1818L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1818	CUB 12.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAGAATAATTGAGAGGGAAGG	0.498													109	149					0	0	0	0	A	16982125	A	A	16982125	2	1	295	1	0	0	0	0	0	0	0	1	4068	1277	45	2		2	CUBN	10	16982125	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1143954	16982125	118552622	226	54597											
MRC1	4360	broad.mit.edu	37	chr10	17905606	17905606	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgaaaaatatttctggacagGactttcagatatacaaacca	17	11	6	7	0	2	2	1	1	1	1	2	4	2	4	1	2	2	0	1	2	6	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:17905606G>C	uc001ipk.2	+	11	1800	c.1697G>C	c.(1696-1698)GGA>GCA	p.G566A		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	566	C-type lectin 3.|Extracellular (Potential).				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						TTCTGGACAGGACTTTCAGAT	0.403													15	62					0	0	0	0	C	17905606	C	C	17905606	3	2	295	1	0	0	0	0	1	0	0	0	9809	1174	41	2	1739	2	MRC1	10	17905606	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	923481	17905606	117629141	227	54598											
FRMPD2	143162	broad.mit.edu	37	chr10	49444559	49444559	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gcagatgtagtgtcatcgggGcctctccagccaacaggatg	9	8	13	11	1	2	1	1	0	1	1	4	2	2	2	3	3	2	2	3	3	2	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:49444559G>T	uc001jgi.2	-	9	1066	c.959C>A	c.(958-960)GCC>GAC	p.A320D	FRMPD2_uc001jgh.2_Missense_Mutation_p.A289D|FRMPD2_uc001jgj.2_Missense_Mutation_p.A298D	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	320					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		TGTCATCGGGGCCTCTCCAGC	0.567													20	60					1.10513e-12	1.43187e-12	1	0	T	49444559	T	T	49444559	3	4	295	1	0	0	0	0	1	0	0	0	6092	1203	42	4	3054	4	FRMPD2	10	49444559	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	31538953	49444559	86090188	228	54599											
CHAT	1103	broad.mit.edu	37	chr10	50872936	50872936	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgcatctctagctttcaCagctgcaaagagacttcttc	9	14	6	12	0	4	1	1	0	3	1	6	2	4	1	0	0	4	4	0	0	2	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:50872936C>A	uc001jhz.2	+	15	2244	c.2091C>A	c.(2089-2091)CAC>CAA	p.H697Q	CHAT_uc001jhv.1_Missense_Mutation_p.H579Q|CHAT_uc001jhx.1_Missense_Mutation_p.H579Q|CHAT_uc001jhy.1_Missense_Mutation_p.H579Q|CHAT_uc001jia.2_Missense_Mutation_p.H579Q|CHAT_uc010qgs.1_Intron	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	697					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CTAGCTTTCACAGCTGCAAAG	0.512													53	208					4.88482e-21	6.97609e-21	1	0	A	50872936	A	A	50872936	3	1	295	1	0	0	0	0	1	0	0	0	3328	477	17	4	2193	4	CHAT	10	50872936	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	1428377	50872936	84661811	229	54600											
ZNF365	22891	broad.mit.edu	37	chr10	64415348	64415348	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagtcgtgctgtggtctctcCgagctcatcacggcacctcc	5	10	11	15	3	3	0	2	0	1	0	7	2	5	0	3	2	2	3	3	2	0	0	rs150729144		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:64415348C>G	uc001jmd.1	+	4	682	c.348C>G	c.(346-348)TCC>TCG	p.S116S	ZNF365_uc001jmc.2_Intron|ZNF365_uc001jme.1_Intron|ZNF365_uc001jmf.1_Intron|ZNF365_uc009xpg.1_Intron	NM_199452	NP_955524	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform D	116										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GTGGTCTCTCCGAGCTCATCA	0.502													22	82					0	0	0	0	G	64415348	G	G	64415348	2	3	295	1	0	0	0	0	0	0	0	1	17936	639	23	3		3	ZNF365	10	64415348	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	13542412	64415348	71119399	230	54601											
KCNMA1	3778	broad.mit.edu	37	chr10	78651359	78651359	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccctattggccagtgtctgcGgggtgctgtagccacctcta	5	11	12	13	1	2	0	0	0	2	0	2	0	2	0	4	3	3	2	4	3	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:78651359G>A	uc001jxn.2	-	26	3443	c.3266C>T	c.(3265-3267)CCG>CTG	p.P1089L	KCNMA1_uc001jxj.2_Missense_Mutation_p.P1035L|KCNMA1_uc001jxk.1_Missense_Mutation_p.P707L|KCNMA1_uc009xrt.1_Missense_Mutation_p.P880L|KCNMA1_uc001jxl.1_Missense_Mutation_p.P714L|KCNMA1_uc001jxo.2_Missense_Mutation_p.P1072L|KCNMA1_uc001jxm.2_Missense_Mutation_p.P1031L|KCNMA1_uc001jxq.2_Missense_Mutation_p.P1061L|uc001jxp.2_Intron	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1089	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CAGTGTCTGCGGGGTGCTGTA	0.627													16	36					0	0	0	0	A	78651359	A	A	78651359	3	1	295	1	0	0	0	0	1	0	0	0	8112	1116	39	1	485	1	KCNMA1	10	78651359	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	14236011	78651359	56883388	231	54602											
KCNMA1	3778	broad.mit.edu	37	chr10	78846265	78846265	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgactcttgcaagatcaTgtggattgaggacggaaccc	10	10	11	10	1	2	3	1	2	1	1	2	6	2	6	2	3	2	1	2	3	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:78846265T>C	uc001jxn.2	-	11	1598	c.1421A>G	c.(1420-1422)CAT>CGT	p.H474R	KCNMA1_uc001jxj.2_Missense_Mutation_p.H474R|KCNMA1_uc001jxk.1_Missense_Mutation_p.H89R|KCNMA1_uc009xrt.1_Missense_Mutation_p.H294R|KCNMA1_uc001jxl.1_Missense_Mutation_p.H128R|KCNMA1_uc001jxo.2_Missense_Mutation_p.H474R|KCNMA1_uc001jxm.2_Missense_Mutation_p.H474R|KCNMA1_uc001jxq.2_Missense_Mutation_p.H474R	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	474	RCK N-terminal.|Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGCAAGATCATGTGGATTGAG	0.502													21	44					0	0	0	0	C	78846265	C	C	78846265	3	2	295	1	0	0	0	0	1	0	0	0	8112	1464	51	5	2533	5	KCNMA1	10	78846265	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	194906	78846265	56688482	232	54603											
SFTPA2	729238	broad.mit.edu	37	chr10	81317057	81317057	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacacactgctcttttccccGacctgcaggctcccctcggt	5	10	7	19	2	1	0	0	0	1	0	4	1	3	0	5	2	2	3	5	2	0	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:81317057G>A	uc001kal.3	-	6	752	c.655C>T	c.(655-657)CGG>TGG	p.R219W	SFTPA2_uc001kan.3_Missense_Mutation_p.R219W	NM_006926	NP_008857	Q8IWL1	SFPA2_HUMAN	RecName: Full=Pulmonary surfactant-associated protein A2;          Short=SP-A2;          Short=SP-A;          Short=PSP-A;          Short=PSPA; AltName: Full=Alveolar proteinosis protein; AltName: Full=35 kDa pulmonary surfactant-associated protein; Flags: Precursor;	219	C-type lectin.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TCTTTTCCCCGACCTGCAGGC	0.557									Pulmonary_Fibrosis_Idiopathic				40	319					0	0	0	0	A	81317057	A	A	81317057	3	1	295	1	0	0	0	0	1	0	0	0	14255	1057	37	1	95	1	SFTPA2	10	81317057	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2470792	81317057	54217690	233	54604											
KIF20B	9585	broad.mit.edu	37	chr10	91528644	91528644	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ccctcaattcttcaatcaaaAggtttgcagaaaattaatta	16	13	4	8	0	4	1	3	0	1	1	4	1	4	1	1	1	1	2	1	1	8	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:91528644A>T	uc001kgs.1	+	31	5313	c.5241A>T	c.(5239-5241)AAA>AAT	p.K1747N	KIF20B_uc001kgr.1_Missense_Mutation_p.K1707N|KIF20B_uc001kgt.1_Missense_Mutation_p.K958N|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1747	Interaction with PIN1.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						TTCAATCAAAAGGTTTGCAGA	0.313													8	29					0	0	0	0	T	91528644	T	T	91528644	3	4	295	1	0	0	0	0	1	0	0	0	8326	86	3	5	5239	5	KIF20B	10	91528644	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	10211587	91528644	44006103	234	54605											
HECTD2	143279	broad.mit.edu	37	chr10	93221100	93221100	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgattctttcccagaattaaAtgctgcatttaaggtaatta	13	16	6	6	0	1	2	0	1	1	1	2	2	2	2	1	1	2	3	1	1	6	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:93221100A>T	uc001khl.2	+	4	597	c.497A>T	c.(496-498)AAT>ATT	p.N166I	LOC100188947_uc010qnl.1_Intron|HECTD2_uc001khk.2_Missense_Mutation_p.N166I|HECTD2_uc010qnm.1_Missense_Mutation_p.N166I|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_5'Flank	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	166					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						CCAGAATTAAATGCTGCATTT	0.274													23	67					0	0	0	0	T	93221100	T	T	93221100	3	4	295	1	0	0	0	0	1	0	0	0	7079	101	4	5	511	5	HECTD2	10	93221100	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	1692456	93221100	42313647	235	54606											
EXOC6	54536	broad.mit.edu	37	chr10	94773979	94773979	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctctgagcctgtgccaggAttccagggggataccctgca	8	8	13	12	0	1	1	0	1	1	0	2	3	2	3	4	3	5	2	4	3	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:94773979A>G	uc001kig.2	+	20	2190	c.2124A>G	c.(2122-2124)GGA>GGG	p.G708G	EXOC6_uc010qnr.1_Silent_p.G724G|EXOC6_uc001kie.2_Silent_p.G703G|EXOC6_uc009xub.2_Silent_p.G707G|EXOC6_uc009xuc.2_Silent_p.G605G|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Silent_p.G282G	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	708					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				CTGTGCCAGGATTCCAGGGGG	0.378													15	47					0	0	0	0	G	94773979	G	G	94773979	2	3	295	1	0	0	0	0	0	0	0	1	5332	320	12	5		5	EXOC6	10	94773979	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	1552879	94773979	40760768	236	54607											
ALDH18A1	5832	broad.mit.edu	37	chr10	97402775	97402775	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aacaatagatgccaagcgccCcagggccaggccacattcat	13	5	9	14	1	1	1	1	0	0	1	1	1	1	1	5	2	3	0	5	2	4	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:97402775C>A	uc001kkz.2	-	3	519	c.277G>T	c.(277-279)GGG>TGG	p.G93W	ALDH18A1_uc001kky.2_Missense_Mutation_p.G93W|ALDH18A1_uc010qog.1_Intron|ALDH18A1_uc010qoh.1_Intron	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	93	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	GCCAAGCGCCCCAGGGCCAGG	0.507													11	34					0.000673444	0.000708305	1	0	A	97402775	A	A	97402775	3	1	295	1	0	0	0	0	1	0	0	0	489	623	22	4	2174	4	ALDH18A1	10	97402775	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2628796	97402775	38131972	237	54608											
PNLIPRP1	5407	broad.mit.edu	37	chr10	118355782	118355782	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	attggccacagcctgggagcCcacgtggctggagaggcagg	8	5	17	11	1	0	1	0	0	0	1	0	3	0	2	3	6	2	2	3	6	0	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:118355782C>G	uc001lco.1	+	6	540	c.522C>G	c.(520-522)GCC>GCG	p.A174A	PNLIPRP1_uc001lcp.2_Silent_p.A174A|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	174					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		GCCTGGGAGCCCACGTGGCTG	0.537													37	156					0	0	0	0	G	118355782	G	G	118355782	2	3	295	1	0	0	0	0	0	0	0	1	12205	610	22	4		4	PNLIPRP1	10	118355782	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	20953007	118355782	17178965	238	54609											
MRGPRX4	117196	broad.mit.edu	37	chr11	18195351	18195351	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agatttcatcccagtcgcgtGgctgatttttttatgtgtgg	6	17	11	7	2	1	2	1	1	0	1	3	2	2	2	1	2	0	1	1	2	1	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:18195351G>C	uc001mnv.1	+	1	968	c.548G>C	c.(547-549)TGG>TCG	p.W183S		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	183	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CCAGTCGCGTGGCTGATTTTT	0.512													77	68					0	0	0	0	C	18195351	C	C	18195351	3	2	295	1	0	0	0	0	1	0	0	0	9822	1357	47	4	550	4	MRGPRX4	11	18195351	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08		18195351	116811165	239	54610											
IGSF22	283284	broad.mit.edu	37	chr11	18741425	18741425	+	Frame_Shift_Del	DEL	G	-	-																															accttcttctgcttcttcttGggagcagggggtgccctagg																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:18741425delG	uc009yht.2	-	7	724	c.534delC	c.(532-534)CCCfs	p.P178fs	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	178	Lys-rich.									ovary(4)|large_intestine(2)|kidney(1)	7						GCTTCTTCTTGGGAGCAGGGG	0.488													---	---	---								-	18741425	-	-	18741425	7	5	295	1	0	1	0	1	0	0	0	0	7639	1335	47	0	3514	0	IGSF22	11	18741425	Frame_Shift_Del	DEL	G	TCGA-F7-7848-01A-11D-2129-08	546074	18741425	116265091	240	54611											
SYT13	57586	broad.mit.edu	37	chr11	45277359	45277359	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgatgacctctggagccgtCacagctggcctgggtccata	7	10	12	12	1	2	2	1	2	1	0	3	3	3	3	4	3	2	1	4	3	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:45277359C>G	uc001myq.2	-	2	393	c.267G>C	c.(265-267)GTG>GTC	p.V89V	SYT13_uc009yku.1_5'UTR	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	89	Cytoplasmic (Potential).					transport vesicle				ovary(1)	1						CTGGAGCCGTCACAGCTGGCC	0.547													34	37					0	0	0	0	G	45277359	G	G	45277359	2	3	295	1	0	0	0	0	0	0	0	1	15535	813	29	2		2	SYT13	11	45277359	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	26535934	45277359	89729157	241	54612											
OR8J3	81168	broad.mit.edu	37	chr11	55904831	55904831	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttacaaatggccacatagcGgtcataggccatcacagcca	13	7	9	12	1	2	0	2	0	0	0	2	0	2	0	3	3	3	1	3	3	4	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:55904831G>A	uc010riz.1	-	1	364	c.364C>T	c.(364-366)CGC>TGC	p.R122C		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					GCCACATAGCGGTCATAGGCC	0.502													25	53					0	0	0	0	A	55904831	A	A	55904831	3	1	295	1	0	0	0	0	1	0	0	0	11296	1116	39	1	585	1	OR8J3	11	55904831	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	10627472	55904831	79101685	242	54613											
MS4A14	84689	broad.mit.edu	37	chr11	60183406	60183406	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atcacctgaagacttgccatCccaagctctaccagtagaag	13	8	7	13	0	2	3	1	1	1	2	3	3	3	3	4	0	3	2	4	0	5	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:60183406C>T	uc001npj.2	+	5	1530	c.965C>T	c.(964-966)TCC>TTC	p.S322F	MS4A14_uc001npi.2_Missense_Mutation_p.S210F|MS4A14_uc001npn.2_Missense_Mutation_p.S60F|MS4A14_uc001npk.2_Missense_Mutation_p.S305F|MS4A14_uc001npl.2_Missense_Mutation_p.S60F|MS4A14_uc001npm.2_Missense_Mutation_p.S60F	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	322						integral to membrane	receptor activity			breast(1)	1						GACTTGCCATCCCAAGCTCTA	0.453													12	19					0	0	0	0	T	60183406	T	T	60183406	3	4	295	1	0	0	0	0	1	0	0	0	9911	855	30	2	983	2	MS4A14	11	60183406	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	4278575	60183406	74823110	243	54614											
PACS1	55690	broad.mit.edu	37	chr11	66008926	66008926	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atagcccatatggggacgtgAttggcctccaggtggactac	9	9	13	10	1	0	1	0	1	0	0	1	3	1	3	3	5	2	0	3	5	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:66008926A>G	uc001oha.1	+	22	2592	c.2458A>G	c.(2458-2460)ATT>GTT	p.I820V	PACS1_uc010rou.1_Missense_Mutation_p.I356V	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	820					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						TGGGGACGTGATTGGCCTCCA	0.592													4	39					0	0	0	0	G	66008926	G	G	66008926	3	3	295	1	0	0	0	0	1	0	0	0	11426	333	12	5	2544	5	PACS1	11	66008926	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	5825520	66008926	68997590	244	54615											
CPT1A	1374	broad.mit.edu	37	chr11	68548156	68548156	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tctgcccaggagtgttcagcGttgaggcccatcttcccgtt	5	12	11	13	2	3	1	1	1	2	0	4	2	4	2	3	2	2	3	3	2	0	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:68548156G>T	uc001oog.3	-	12	1580	c.1410C>A	c.(1408-1410)AAC>AAA	p.N470K	CPT1A_uc001oof.3_Missense_Mutation_p.N470K|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	470	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	AGTGTTCAGCGTTGAGGCCCA	0.463													172	84					6.83575e-98	1.01514e-97	1	0	T	68548156	T	T	68548156	3	4	295	1	0	0	0	0	1	0	0	0	3846	1136	40	3	983	3	CPT1A	11	68548156	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2539230	68548156	66458360	245	54616											
MRPL21	219927	broad.mit.edu	37	chr11	68665462	68665462	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggccaaggtggtgaactcagGgatgttttaggaacatatct	11	11	13	6	0	2	1	1	1	1	0	2	3	2	3	1	5	2	1	1	5	5	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:68665462G>T	uc001ooi.2	-	3	190	c.165C>A	c.(163-165)TCC>TCA	p.S55S	MRPL21_uc001ooh.2_5'UTR|MRPL21_uc010rqe.1_Silent_p.S55S	NM_181514	NP_852615	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21 isoform d	55					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GTGAACTCAGGGATGTTTTAG	0.473													74	197					5.76837e-54	8.53795e-54	1	0	T	68665462	T	T	68665462	2	4	295	1	0	0	0	0	0	0	0	1	9840	1219	43	4		4	MRPL21	11	68665462	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	117306	68665462	66341054	246	54617											
AMOTL1	154810	broad.mit.edu	37	chr11	94533290	94533290	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accctcggggtcctccacctGagtaccccttcaagaccaag	9	7	8	17	1	1	2	1	1	0	1	4	2	3	2	7	2	1	1	7	2	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:94533290G>T	uc001pfb.2	+	3	1104	c.934G>T	c.(934-936)GAG>TAG	p.E312*	AMOTL1_uc001pfc.2_Nonsense_Mutation_p.E262*	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	312						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				TCCTCCACCTGAGTACCCCTT	0.602													59	65					7.47603e-22	1.07799e-21	1	0	T	94533290	T	T	94533290	4	4	295	1	0	0	0	0	0	1	0	0	583	1291	45	2	944	2	AMOTL1	11	94533290	Nonsense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	25867828	94533290	40473226	247	54618											
MAML2	84441	broad.mit.edu	37	chr11	95713064	95713065	+	Frame_Shift_Del	DEL	GT	-	-																															tggaattgggagttaaaatgGtgtgtgttgaaactgggttt																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:95713064_95713065delGT	uc001pfw.1	-	5	3803_3804	c.2518_2519delAC	c.(2518-2520)ACCfs	p.T840fs		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	840					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				AGTTAAAATGGTGTGTGTTGAA	0.421			T	MECT1|CRTC3	salivary gland mucoepidermoid								---	---	---								-	95713065	-	-	95713064	7	5	295	1	0	1	0	1	0	0	0	0	9259	1261	44	0	955	0	MAML2	11	95713064	Frame_Shift_Del	DEL	GT	TCGA-F7-7848-01A-11D-2129-08	1179774	95713064	39293452	248	54619											
MMP8	4317	broad.mit.edu	37	chr11	102593338	102593338	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagcttttcaacgatcacatTagtgccattcttccttgtag	10	15	6	10	1	3	0	2	0	1	0	4	1	4	0	2	0	3	2	2	0	4	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:102593338T>C	uc001phe.2	-	2	268	c.169A>G	c.(169-171)AAT>GAT	p.N57D	MMP8_uc010rut.1_5'UTR|MMP8_uc010ruu.1_Missense_Mutation_p.N34D	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	57					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		ACGATCACATTAGTGCCATTC	0.433													27	32					0	0	0	0	C	102593338	C	C	102593338	3	2	295	1	0	0	0	0	1	0	0	0	9721	1754	61	5	1270	5	MMP8	11	102593338	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	6880274	102593338	32413178	249	54620											
CDON	50937	broad.mit.edu	37	chr11	125871614	125871614	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taaaatattcttctttttacCtccactgtgcctagaggaat	11	16	5	9	0	2	1	0	0	2	1	3	2	3	2	3	1	2	0	3	1	6	8			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:125871614C>T	uc009zbw.2	-	11	2286	c.2158G>A	c.(2158-2160)GTT>ATT	p.V720I	CDON_uc001qdb.3_Missense_Mutation_p.V97I|CDON_uc001qdc.3_Missense_Mutation_p.V720I	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	720	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		TTCTTTTTACCTCCACTGTGC	0.408													13	27					0	0	0	0	T	125871614	T	T	125871614	3	4	295	1	0	0	0	0	1	0	0	0	3185	695	24	4	1676	4	CDON	11	125871614	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	23278276	125871614	9134902	250	54621											
ATN1	1822	broad.mit.edu	37	chr12	7047905	7047905	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccggccctgtacagcagtGatccagctgcccgggagagg	7	6	14	14	2	0	2	0	1	0	1	2	3	2	2	4	3	4	3	4	3	1	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:7047905G>T	uc001qrw.1	+	7	3016	c.2779G>T	c.(2779-2781)GAT>TAT	p.D927Y	ATN1_uc001qrx.1_Missense_Mutation_p.D927Y	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	927					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GTACAGCAGTGATCCAGCTGC	0.622													38	174					8.16277e-20	1.15103e-19	1	0	T	7047905	T	T	7047905	3	4	295	1	0	0	0	0	1	0	0	0	1113	1290	45	2	2801	2	ATN1	12	7047905	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08		7047905	126803990	251	54622											
CLEC4D	338339	broad.mit.edu	37	chr12	8667867	8667867	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	atccccagctgataccttcgGttattgctgtagttttcatc	7	16	7	11	1	1	1	1	1	0	0	4	1	2	1	3	1	3	5	3	1	3	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:8667867G>T	uc001qun.2	+	2	257	c.64G>T	c.(64-66)GTT>TTT	p.V22F		NM_080387	NP_525126	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	22	Helical; Signal-anchor for type II membrane protein; (Potential).				innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)					GATACCTTCGGTTATTGCTGT	0.378													33	139					1.04594e-18	1.45649e-18	1	0	T	8667867	T	T	8667867	3	4	295	1	0	0	0	0	1	0	0	0	3529	1261	44	4	70	4	CLEC4D	12	8667867	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1619962	8667867	125184028	252	54623											
GRIN2B	2904	broad.mit.edu	37	chr12	13768124	13768124	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtctctatgaagggcacAgagaagtcgaccacctccga	11	7	10	13	2	1	2	0	1	1	1	4	5	2	2	4	1	0	1	4	1	3	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:13768124A>G	uc001rbt.2	-	7	1757	c.1578T>C	c.(1576-1578)TCT>TCC	p.S526S		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	526	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGAAGGGCACAGAGAAGTCGA	0.527													16	92					0	0	0	0	G	13768124	G	G	13768124	2	3	295	1	0	0	0	0	0	0	0	1	6819	175	7	5		5	GRIN2B	12	13768124	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	5100257	13768124	120083771	253	54624											
GRIN2B	2904	broad.mit.edu	37	chr12	14018745	14018745	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tttttaccttatctgccattAtcatagaggagcccccgtgg	8	14	8	11	1	2	1	1	0	1	1	2	2	2	2	4	2	3	0	4	2	4	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:14018745A>G	uc001rbt.2	-	2	577	c.398T>C	c.(397-399)ATA>ACA	p.I133T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	133	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATCTGCCATTATCATAGAGGA	0.502													36	211					0	0	0	0	G	14018745	G	G	14018745	3	3	295	1	0	0	0	0	1	0	0	0	6819	449	16	5	4104	5	GRIN2B	12	14018745	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	250621	14018745	119833150	254	54625											
PDE3A	5139	broad.mit.edu	37	chr12	20801724	20801724	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataacttcttaattaaccttGaccatgtggaatttaagcat	14	15	5	7	0	1	1	0	1	1	0	1	2	1	2	2	1	3	1	2	1	5	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:20801724G>T	uc001reh.1	+	13	2690	c.2668G>T	c.(2668-2670)GAC>TAC	p.D890Y		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	890	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AATTAACCTTGACCATGTGGA	0.408													34	129					9.17885e-22	1.31928e-21	1	0	T	20801724	T	T	20801724	3	4	295	1	0	0	0	0	1	0	0	0	11691	1290	45	2	2718	2	PDE3A	12	20801724	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	6782979	20801724	113050171	255	54626											
SLCO1B1	10599	broad.mit.edu	37	chr12	21327510	21327510	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ataattttgttccctttctaGgaaatttgcttgtgattgta	9	20	7	5	0	1	1	0	1	1	0	2	2	2	2	1	1	1	3	1	1	4	10			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:21327510G>C	uc001req.3	+	4	331	c.227_splice	c.e4-1	p.G76_splice		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,						bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TCCCTTTCTAGGAAATTTGCT	0.363													12	18					0	0	0	0	C	21327510	C	C	21327510	5	2	295	1	0	0	0	0	0	0	1	0	14787	1014	35	4	236	4	SLCO1B1	12	21327510	Splice_Site	SNP	G	TCGA-F7-7848-01A-11D-2129-08	525786	21327510	112524385	256	54627											
KCNH3	23416	broad.mit.edu	37	chr12	49936579	49936579	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgtgctctaccacctgtccgGgcacctgcagaagcagccca	8	6	10	17	2	1	1	0	0	1	1	2	1	2	1	5	1	5	4	5	1	2	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:49936579G>C	uc001ruh.1	+	4	796	c.536G>C	c.(535-537)GGG>GCG	p.G179A	KCNH3_uc010smj.1_Missense_Mutation_p.G119A	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	179	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						CACCTGTCCGGGCACCTGCAG	0.652													4	2					0	0	0	0	C	49936579	C	C	49936579	3	2	295	1	0	0	0	0	1	0	0	0	8072	1232	43	4	550	4	KCNH3	12	49936579	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	28609069	49936579	83915316	257	54628											
KRT6B	3854	broad.mit.edu	37	chr12	52842695	52842695	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttgatctcagcaatctcctgCttggtgttgcgcaggtcgtc	5	14	11	11	2	2	1	1	1	2	0	6	1	2	1	1	2	3	4	1	2	1	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:52842695C>T	uc001sak.2	-	6	1182	c.1134G>A	c.(1132-1134)AAG>AAA	p.K378K		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	378	Rod.|Coil 2.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		CAATCTCCTGCTTGGTGTTGC	0.552													29	49					0	0	0	0	T	52842695	T	T	52842695	2	4	295	1	0	0	0	0	0	0	0	1	8520	796	28	4		4	KRT6B	12	52842695	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2906116	52842695	81009200	258	54629											
OR6C65	403282	broad.mit.edu	37	chr12	55794728	55794728	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catcatgagtaacaaagtctGtaattggcttgtaatcagct	13	13	8	7	0	3	1	2	1	1	0	3	1	3	1	0	1	2	5	0	1	4	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:55794728G>A	uc010spl.1	+	1	416	c.416G>A	c.(415-417)TGT>TAT	p.C139Y		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AACAAAGTCTGTAATTGGCTT	0.418													56	80					0	0	0	0	A	55794728	A	A	55794728	3	1	295	1	0	0	0	0	1	0	0	0	11249	1377	48	4	418	4	OR6C65	12	55794728	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2952033	55794728	78057167	259	54630											
NAV3	89795	broad.mit.edu	37	chr12	78522567	78522567	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctactggagggcttcaggaCactggcaaccagtcacctct	9	9	10	13	0	4	0	2	0	2	0	4	2	4	2	2	4	2	2	2	4	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:78522567C>T	uc001syp.2	+	18	4535	c.4362C>T	c.(4360-4362)GAC>GAT	p.D1454D	NAV3_uc001syo.2_Silent_p.D1454D|NAV3_uc010sub.1_Silent_p.D940D|NAV3_uc009zsf.2_Silent_p.D285D	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1454	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GGCTTCAGGACACTGGCAACC	0.463										HNSCC(70;0.22)			24	44					0	0	0	0	T	78522567	T	T	78522567	2	4	295	1	0	0	0	0	0	0	0	1	10238	477	17	4		4	NAV3	12	78522567	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	22727839	78522567	55329328	260	54631											
LIN7A	8825	broad.mit.edu	37	chr12	81283142	81283142	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccagtaattcaattgctcttGcaacatctgaatgaaaaaaa	17	11	5	8	0	3	2	1	2	2	0	3	2	3	2	1	0	3	3	1	0	7	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:81283142G>C	uc001szj.1	-	2	282	c.89C>G	c.(88-90)GCA>GGA	p.A30G	LIN7A_uc001szk.1_RNA	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	30	L27.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						AATTGCTCTTGCAACATCTGA	0.343													12	13					0	0	0	0	C	81283142	C	C	81283142	3	2	295	1	0	0	0	0	1	0	0	0	8852	1319	46	4	628	4	LIN7A	12	81283142	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2760575	81283142	52568753	261	54632											
PLXNC1	10154	broad.mit.edu	37	chr12	94648656	94648656	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagcgagctccggaaagagaTacgtgacggtaggctccaaa	14	5	13	9	4	0	2	0	1	0	1	2	5	2	3	2	3	3	3	2	3	5	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:94648656T>A	uc001tdc.2	+	16	3224	c.2975T>A	c.(2974-2976)ATA>AAA	p.I992K	PLXNC1_uc010sut.1_Missense_Mutation_p.I39K	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	992	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						CGGAAAGAGATACGTGACGGT	0.433													4	9					0	0	0	0	A	94648656	A	A	94648656	3	1	295	1	0	0	0	0	1	0	0	0	12181	1406	49	5	3037	5	PLXNC1	12	94648656	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	13365514	94648656	39203239	262	54633											
PAH	5053	broad.mit.edu	37	chr12	103245509	103245509	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgaaaacaagggcacatGtcccaacagctcatggcaga	15	6	9	11	0	2	2	1	1	1	1	3	2	3	2	1	2	3	3	1	2	4	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:103245509G>A	uc001tjq.1	-	9	1340	c.868C>T	c.(868-870)CAT>TAT	p.H290Y		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	290		Iron (By similarity).			catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	AAGGGCACATGTCCCAACAGC	0.468													7	26					0	0	0	0	A	103245509	A	A	103245509	3	1	295	1	0	0	0	0	1	0	0	0	11448	1377	48	4	514	4	PAH	12	103245509	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	8596853	103245509	30606386	263	54634											
KDM2B	84678	broad.mit.edu	37	chr12	121879997	121879997	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagacccgcatgcacacacAcaggtcttggtggctgaggt	9	7	13	12	1	1	2	0	1	1	1	1	2	1	2	1	4	1	4	1	4	0	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:121879997A>T	uc001uat.2	-	19	3351	c.3247T>A	c.(3247-3249)TGT>AGT	p.C1083S	KDM2B_uc001uaq.2_Missense_Mutation_p.C523S|KDM2B_uc010szy.1_Missense_Mutation_p.C523S|KDM2B_uc001uar.2_Missense_Mutation_p.C674S|KDM2B_uc001uas.2_Missense_Mutation_p.C1014S|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_Missense_Mutation_p.C331S|KDM2B_uc010szx.1_Missense_Mutation_p.C331S|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	1083	F-box.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						ATGCACACACACAGGTCTTGG	0.662													12	53					0	0	0	0	T	121879997	T	T	121879997	3	4	295	1	0	0	0	0	1	0	0	0	8164	159	6	5	835	5	KDM2B	12	121879997	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	18634488	121879997	11971898	264	54635											
CKAP2	26586	broad.mit.edu	37	chr13	53035751	53035751	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagtcatcacagtaataccCgggacactgtgaaacaaggc	15	6	10	10	1	2	1	2	1	0	0	2	3	2	2	1	2	2	1	1	2	5	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr13:53035751C>T	uc001vgv.2	+	4	990	c.793C>T	c.(793-795)CGG>TGG	p.R265W	CKAP2_uc001vgt.2_Missense_Mutation_p.R264W|CKAP2_uc001vgu.2_Missense_Mutation_p.R264W|CKAP2_uc010tha.1_Missense_Mutation_p.R216W	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	265					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		CAGTAATACCCGGGACACTGT	0.408													14	22					0	0	0	0	T	53035751	T	T	53035751	3	4	295	1	0	0	0	0	1	0	0	0	3457	643	23	1	807	1	CKAP2	13	53035751	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08		53035751	62134127	265	54636											
PCDH20	64881	broad.mit.edu	37	chr13	61986650	61986650	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattggagcattatcattgtCatctaaaagttgcactttaa	14	15	6	6	0	3	0	2	0	1	0	3	1	3	1	0	1	2	3	0	1	5	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr13:61986650C>T	uc001vid.3	-	2	1946	c.1582G>A	c.(1582-1584)GAC>AAC	p.D528N	PCDH20_uc010thj.1_Missense_Mutation_p.D528N	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	501	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TTATCATTGTCATCTAAAAGT	0.398													44	89					0	0	0	0	T	61986650	T	T	61986650	3	4	295	1	0	0	0	0	1	0	0	0	11569	826	29	2	1277	2	PCDH20	13	61986650	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	8950899	61986650	53183228	266	54637											
SLITRK5	26050	broad.mit.edu	37	chr13	88328295	88328295	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgaaacttctgccctacGtggggctcttgcagcacatg	7	10	12	12	1	2	1	0	1	2	0	2	1	2	1	1	3	5	4	1	3	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr13:88328295G>T	uc001vln.2	+	2	871	c.652G>T	c.(652-654)GTG>TTG	p.V218L	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	218	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TCTGCCCTACGTGGGGCTCTT	0.483													34	51					3.33393e-15	4.44856e-15	1	0	T	88328295	T	T	88328295	3	4	295	1	0	0	0	0	1	0	0	0	14810	1145	40	3	654	3	SLITRK5	13	88328295	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	26341645	88328295	26841583	267	54638											
DZIP1	22873	broad.mit.edu	37	chr13	96237044	96237044	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaggcatttagcacatgagCaaaatgtggttcatttttcg	11	13	9	8	1	1	1	1	1	0	0	2	1	1	1	1	2	2	4	1	2	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr13:96237044C>T	uc001vmk.2	-	22	3322	c.2470G>A	c.(2470-2472)GCT>ACT	p.A824T	DZIP1_uc001vmi.2_Missense_Mutation_p.A72T|DZIP1_uc001vmj.2_Missense_Mutation_p.A300T|DZIP1_uc001vml.2_Missense_Mutation_p.A805T|DZIP1_uc001vmm.2_5'Flank	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	824					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			AGCACATGAGCAAAATGTGGT	0.438													24	43					0	0	0	0	T	96237044	T	T	96237044	3	4	295	1	0	0	0	0	1	0	0	0	4885	710	25	4	141	4	DZIP1	13	96237044	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	7908749	96237044	18932834	268	54639											
FARP1	10160	broad.mit.edu	37	chr13	99087858	99087858	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcagagatcacggagatggtGgcacagctccacggtacgat	11	6	14	10	3	1	2	1	0	0	2	2	5	2	2	1	4	2	4	1	4	1	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr13:99087858G>C	uc001vnj.2	+	19	2508	c.2172G>C	c.(2170-2172)GTG>GTC	p.V724V	FARP1_uc001vnh.2_Silent_p.V724V	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	724	DH.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CGGAGATGGTGGCACAGCTCC	0.517													19	29					0	0	0	0	C	99087858	C	C	99087858	2	2	295	1	0	0	0	0	0	0	0	1	5708	1335	47	4		4	FARP1	13	99087858	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2850814	99087858	16082020	269	54640											
OR4Q3	441669	broad.mit.edu	37	chr14	20215674	20215674	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcagctatttctcttcttaCtatttttgtttttttacatt	6	25	3	7	0	2	0	0	0	2	0	3	0	2	0	0	0	4	3	0	0	4	12	rs4494468		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:20215674C>A	uc010tkt.1	+	1	88	c.88C>A	c.(88-90)CTA>ATA	p.L30I		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTCTTCTTACTATTTTTGTT	0.378													19	87					7.45023e-12	9.46094e-12	1	0	A	20215674	A	A	20215674	3	1	295	1	0	0	0	0	1	0	0	0	11135	564	20	4	90	4	OR4Q3	14	20215674	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08		20215674	87133866	270	54641											
CCNB1IP1	57820	broad.mit.edu	37	chr14	20781866	20781866	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtcaattctacatccttgCtttgtatttgctgagtatat	9	18	7	7	0	2	1	1	1	1	0	3	1	3	1	1	1	3	4	1	1	5	8			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:20781866C>G	uc001vwv.2	-	6	1041	c.392G>C	c.(391-393)AGC>ACC	p.S131T	CCNB1IP1_uc001vww.2_Missense_Mutation_p.S131T|CCNB1IP1_uc001vwx.2_Missense_Mutation_p.S131T|CCNB1IP1_uc001vwy.2_Missense_Mutation_p.S131T|CCNB1IP1_uc001vwz.2_Missense_Mutation_p.S131T	NM_182851	NP_878271	Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1 isoform 3	131	Potential.					chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	soft_tissue(2)|ovary(1)	3	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)		TACATCCTTGCTTTGTATTTG	0.393			T	HMGA2	leiomyoma								5	103					0	0	0	0	G	20781866	G	G	20781866	3	3	295	1	0	0	0	0	1	0	0	0	2927	797	28	4	449	4	CCNB1IP1	14	20781866	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	566192	20781866	86567674	271	54642											
SALL2	6297	broad.mit.edu	37	chr14	21991721	21991721	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgttggggatctggccccccAggtgcatccggacatgctgc	5	8	14	14	2	1	0	0	0	1	0	2	2	2	2	4	5	3	3	4	5	0	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:21991721A>C	uc001wbe.2	-	2	2423	c.2141T>G	c.(2140-2142)CTG>CGG	p.L714R	SALL2_uc010tly.1_Missense_Mutation_p.L712R|SALL2_uc010tlz.1_Missense_Mutation_p.L577R|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Missense_Mutation_p.L579R|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	714							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CTGGCCCCCCAGGTGCATCCG	0.607													5	36					0	0	0	0	C	21991721	C	C	21991721	3	2	295	1	0	0	0	0	1	0	0	0	13876	188	7	5	886	5	SALL2	14	21991721	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	1209855	21991721	85357819	272	54643											
IPO4	79711	broad.mit.edu	37	chr14	24652822	24652822	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcacagagatctcccccacGgcagcacaggtgtcttcctt	8	10	8	15	1	3	1	1	0	2	1	5	2	4	1	3	2	1	2	3	2	0	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:24652822G>A	uc001wmv.1	-	20	2168	c.2037C>T	c.(2035-2037)GCC>GCT	p.A679A	IPO4_uc001wmt.1_Silent_p.A157A|IPO4_uc001wmu.2_Silent_p.A341A|IPO4_uc001wmx.1_Silent_p.A543A|IPO4_uc001wmy.1_Silent_p.A543A|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Silent_p.A679A	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	679					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		TCTCCCCCACGGCAGCACAGG	0.577													8	44					0	0	0	0	A	24652822	A	A	24652822	2	1	295	1	0	0	0	0	0	0	0	1	7834	1103	39	1		1	IPO4	14	24652822	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2661101	24652822	82696718	273	54644											
RALGAPA1	253959	broad.mit.edu	37	chr14	36128345	36128345	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaagaatatccgacctaccGtgcaggaccagagggctcat	12	7	10	12	2	1	2	1	0	0	2	2	4	2	3	4	2	2	2	4	2	4	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:36128345G>A	uc001wti.2	-	27	4259	c.3868C>T	c.(3868-3870)CGA>TGA	p.R1290*	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Nonsense_Mutation_p.R1290*|RALGAPA1_uc010tpv.1_Nonsense_Mutation_p.R1303*|RALGAPA1_uc010tpw.1_Nonsense_Mutation_p.R1337*	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1290					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						CCGACCTACCGTGCAGGACCA	0.373													9	27					0	0	0	0	A	36128345	A	A	36128345	4	1	295	1	0	0	0	0	0	1	0	0	13078	1159	40	1	2451	1	RALGAPA1	14	36128345	Nonsense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	11475523	36128345	71221195	274	54645											
SSTR1	6751	broad.mit.edu	37	chr14	38678848	38678848	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtcatctacgtgatcctgcGctatgccaagatgaagacgg	10	9	12	10	3	2	4	1	2	1	2	3	4	3	4	2	2	3	1	2	2	4	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:38678848G>T	uc001wul.1	+	3	871	c.254G>T	c.(253-255)CGC>CTC	p.R85L	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	85	Cytoplasmic (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GTGATCCTGCGCTATGCCAAG	0.562													22	87					1.96895e-08	2.30398e-08	1	0	T	38678848	T	T	38678848	3	4	295	1	0	0	0	0	1	0	0	0	15263	1087	38	3	256	3	SSTR1	14	38678848	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2550503	38678848	68670692	275	54646											
RPL10L	140801	broad.mit.edu	37	chr14	47120455	47120455	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagatatgaatcttctggCgtccagggaacttgaacttg	10	12	12	7	1	2	3	0	2	2	1	3	5	3	4	1	3	2	0	1	3	4	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:47120455C>A	uc001wwg.2	-	1	574	c.485G>T	c.(484-486)CGC>CTC	p.R162L		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	162					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						AATCTTCTGGCGTCCAGGGAA	0.498													35	103					5.8336e-16	7.90188e-16	1	0	A	47120455	A	A	47120455	3	1	295	1	0	0	0	0	1	0	0	0	13621	768	27	3	163	3	RPL10L	14	47120455	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	8441607	47120455	60229085	276	54647											
ARF6	382	broad.mit.edu	37	chr14	50360768	50360768	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggctcgccaggagctgcaccGcattatcaatgaccgggaga	10	6	13	12	3	1	2	1	1	0	1	2	4	1	3	3	3	2	4	3	3	2	1	rs61755568		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:50360768G>C	uc001wxg.3	+	2	935	c.314G>C	c.(313-315)CGC>CCC	p.R105P		NM_001663	NP_001654	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	105					cell adhesion|cellular component movement|cortical actin cytoskeleton organization|negative regulation of receptor-mediated endocytosis|positive regulation of actin filament polymerization|positive regulation of establishment of protein localization in plasma membrane|protein localization at cell surface|protein transport|regulation of dendritic spine development|regulation of filopodium assembly|regulation of Rac protein signal transduction|ruffle organization|small GTPase mediated signal transduction|vesicle-mediated transport	cell cortex|endosome membrane|filopodium membrane|Golgi apparatus|membrane fraction|ruffle	GTP binding|GTPase activity|thioesterase binding				0	all_epithelial(31;0.000822)|Breast(41;0.0117)					GAGCTGCACCGCATTATCAAT	0.587													15	45					0	0	0	0	C	50360768	C	C	50360768	3	2	295	1	0	0	0	0	1	0	0	0	848	1087	38	3	316	3	ARF6	14	50360768	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3240313	50360768	56988772	277	54648											
NRXN3	9369	broad.mit.edu	37	chr14	80164140	80164140	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatcaatggaagtgttcggCtggttggagaagtcccatca	12	10	12	7	1	2	1	2	0	0	1	4	3	3	2	1	4	0	3	1	4	4	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:80164140C>A	uc001xun.2	+	15	3156	c.2665C>A	c.(2665-2667)CTG>ATG	p.L889M	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.L257M|NRXN3_uc010asw.2_Missense_Mutation_p.L287M|NRXN3_uc001xur.3_Missense_Mutation_p.L257M	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1262	Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		AAGTGTTCGGCTGGTTGGAGA	0.458													17	44					5.3912e-06	5.96502e-06	1	0	A	80164140	A	A	80164140	3	1	295	1	0	0	0	0	1	0	0	0	10721	796	28	4	3060	4	NRXN3	14	80164140	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	29803372	80164140	27185400	278	54649											
DICER1	23405	broad.mit.edu	37	chr14	95574699	95574699	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtcagtattccaaagcatcTtgtggtatcttcaggaggat	10	13	10	8	1	4	0	2	0	2	0	5	2	5	2	1	3	1	3	1	3	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:95574699T>G	uc001ydw.2	-	16	2580	c.2398A>C	c.(2398-2400)AGA>CGA	p.R800R	DICER1_uc010avh.1_5'Flank|DICER1_uc001ydv.2_Silent_p.R790R|DICER1_uc001ydx.2_Silent_p.R800R	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	800					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CCAAAGCATCTTGTGGTATCT	0.398			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				34	135					0	0	0	0	G	95574699	G	G	95574699	2	3	295	1	0	0	0	0	0	0	0	1	4543	1617	56	5		5	DICER1	14	95574699	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	15410559	95574699	11774841	279	54650											
DLK1	8788	broad.mit.edu	37	chr14	101194741	101194741	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttgtacctcaggggctgaaTgcttcccggcctgcaacccc	6	9	10	16	1	1	1	1	1	0	0	2	1	2	1	5	3	4	4	5	3	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:101194741T>G	uc001yhs.3	+	2	229	c.76T>G	c.(76-78)TGC>GGC	p.C26G	DLK1_uc001yhu.3_Missense_Mutation_p.C26G	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	26	Extracellular (Potential).|EGF-like 1.				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				AGGGGCTGAATGCTTCCCGGC	0.572													30	73					0	0	0	0	G	101194741	G	G	101194741	3	3	295	1	0	0	0	0	1	0	0	0	4586	1464	51	5	82	5	DLK1	14	101194741	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	5620042	101194741	6154799	280	54651											
ATP10A	57194	broad.mit.edu	37	chr15	25940061	25940061	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagcagaggacggagcggCactgcttggcaaggaagagg	12	3	18	8	2	0	2	0	0	0	2	0	6	0	5	0	6	3	4	0	6	2	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:25940061C>A	uc010ayu.2	-	14	3099	c.2993G>T	c.(2992-2994)TGC>TTC	p.C998F		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	998	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GACGGAGCGGCACTGCTTGGC	0.607													18	38					1.67942e-08	1.98598e-08	1	0	A	25940061	A	A	25940061	3	1	295	1	0	0	0	0	1	0	0	0	1118	710	25	4	1538	4	ATP10A	15	25940061	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08		25940061	76591331	281	54652											
TJP1	7082	broad.mit.edu	37	chr15	30012801	30012801	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgtgtctgtgtcttcatagtCagaagtgtgtctactgtccg	6	16	11	8	1	5	1	2	0	3	1	6	1	6	1	1	0	1	0	1	0	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:30012801C>T	uc001zcr.2	-	19	2999	c.2524G>A	c.(2524-2526)GAC>AAC	p.D842N	TJP1_uc010azl.2_Missense_Mutation_p.D830N|TJP1_uc001zcq.2_Missense_Mutation_p.D846N|TJP1_uc001zcs.2_Missense_Mutation_p.D842N	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	842					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TCTTCATAGTCAGAAGTGTGT	0.463													30	44					0	0	0	0	T	30012801	T	T	30012801	3	4	295	1	0	0	0	0	1	0	0	0	15995	826	29	2	2762	2	TJP1	15	30012801	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	4072740	30012801	72518591	282	54653											
OTUD7A	161725	broad.mit.edu	37	chr15	31819495	31819495	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtaacaccaggtcccggtcGtgaaacccccacattcctgg	9	7	9	16	3	0	1	0	1	0	0	3	1	2	1	5	3	2	1	5	3	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:31819495G>C	uc001zfq.2	-	5	762	c.669C>G	c.(667-669)CAC>CAG	p.H223Q	OTUD7A_uc001zfr.2_Missense_Mutation_p.H223Q	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	223	OTU.|Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GGTCCCGGTCGTGAAACCCCC	0.577													16	171					0	0	0	0	C	31819495	C	C	31819495	3	2	295	1	0	0	0	0	1	0	0	0	11372	1136	40	3	2139	3	OTUD7A	15	31819495	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1806694	31819495	70711897	283	54654											
RYR3	6263	broad.mit.edu	37	chr15	33855069	33855069	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaattagactccagtcacaAgcgagacatagaaggcatgg	16	6	11	8	1	1	3	1	0	0	3	2	5	2	3	1	2	1	1	1	2	5	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:33855069A>T	uc001zhi.2	+	11	1074	c.1004A>T	c.(1003-1005)AAG>ATG	p.K335M	RYR3_uc010bar.2_Missense_Mutation_p.K335M	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	335	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCAGTCACAAGCGAGACATA	0.403													13	27					0	0	0	0	T	33855069	T	T	33855069	3	4	295	1	0	0	0	0	1	0	0	0	13835	72	3	5	1046	5	RYR3	15	33855069	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	2035574	33855069	68676323	284	54655											
LTK	4058	broad.mit.edu	37	chr15	41801279	41801279	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggggtgtatgaaggatactCcatcttccccatcagcccag	9	10	10	12	0	2	1	1	1	1	0	4	2	4	2	4	3	2	1	4	3	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:41801279C>A	uc001zoa.3	-	8	1224	c.1046G>T	c.(1045-1047)GGA>GTA	p.G349V	LTK_uc001zob.3_Missense_Mutation_p.G288V|LTK_uc010ucx.1_Missense_Mutation_p.G288V|LTK_uc010bcg.2_Missense_Mutation_p.G31V	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	349	Extracellular (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		GAAGGATACTCCATCTTCCCC	0.577										TSP Lung(18;0.14)			9	79					1.76689e-08	2.07842e-08	1	0	A	41801279	A	A	41801279	3	1	295	1	0	0	0	0	1	0	0	0	9130	855	30	2	1600	2	LTK	15	41801279	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	7946210	41801279	60730113	285	54656											
SPATA5L1	79029	broad.mit.edu	37	chr15	45695581	45695581	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggggcagtcgagcacccgaGagccgcgtagtggcccaggt	7	4	17	13	5	0	1	0	0	0	1	1	3	0	1	3	4	2	3	3	4	1	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:45695581G>C	uc001zve.2	+	1	1063	c.954G>C	c.(952-954)GAG>GAC	p.E318D	uc001zvd.2_5'Flank|SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	318						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		GAGCACCCGAGAGCCGCGTAG	0.697													11	15					0	0	0	0	C	45695581	C	C	45695581	3	2	295	1	0	0	0	0	1	0	0	0	15078	933	33	2	956	2	SPATA5L1	15	45695581	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3894302	45695581	56835811	286	54657											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84582010	84582010	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccgaacggccctgcctcctgGaagcatgtgatgagagcccg	8	6	13	14	3	0	2	0	2	0	1	1	5	1	3	5	2	4	1	5	2	2	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:84582010G>A	uc002bjz.3	+	16	2091	c.1867G>A	c.(1867-1869)GAA>AAA	p.E623K	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.E623K|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.E623K	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	623	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTGCCTCCTGGAAGCATGTGA	0.612													12	24					0	0	0	0	A	84582010	A	A	84582010	3	1	295	1	0	0	0	0	1	0	0	0	276	1175	41	2	1925	2	ADAMTSL3	15	84582010	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	38886429	84582010	17949382	287	54658											
ALPK3	57538	broad.mit.edu	37	chr15	85360196	85360196	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttggctccctggtctcccgcGgtctagcccaagctggccag	4	9	12	16	2	2	0	0	0	2	0	4	0	3	0	4	4	2	2	4	4	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:85360196G>T	uc002ble.2	+	1	286	c.119G>T	c.(118-120)CGG>CTG	p.R40L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	40					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGTCTCCCGCGGTCTAGCCCA	0.682													4	30					0.00909568	0.00930382	1	0	T	85360196	T	T	85360196	3	4	295	1	0	0	0	0	1	0	0	0	546	1116	39	3	121	3	ALPK3	15	85360196	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	778186	85360196	17171196	288	54659											
SV2B	9899	broad.mit.edu	37	chr15	91811780	91811780	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agcatgtgtacggcgccacaAtcaacttcacgatggaaaat	14	8	9	10	3	2	0	2	0	0	0	2	2	2	1	1	2	3	2	1	2	5	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:91811780A>G	uc002bqv.2	+	8	1709	c.1318A>G	c.(1318-1320)ATC>GTC	p.I440V	SV2B_uc002bqt.2_Missense_Mutation_p.I440V|SV2B_uc010uqv.1_Missense_Mutation_p.I289V|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	440	Extracellular (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CGGCGCCACAATCAACTTCAC	0.428													19	105					0	0	0	0	G	91811780	G	G	91811780	3	3	295	1	0	0	0	0	1	0	0	0	15484	101	4	5	1348	5	SV2B	15	91811780	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	6451584	91811780	10719612	289	54660											
IFT140	9742	broad.mit.edu	37	chr16	1570757	1570757	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtcatcttttccgccatcTcctcggtgatgctcatgttc	4	15	8	14	3	4	1	2	1	2	0	8	1	5	1	3	2	1	2	3	2	0	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:1570757T>C	uc002cmb.2	-	27	3868	c.3506A>G	c.(3505-3507)GAG>GGG	p.E1169G	IFT140_uc002clz.2_Missense_Mutation_p.E782G	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	1169										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				TTCCGCCATCTCCTCGGTGAT	0.632													11	37					0	0	0	0	C	1570757	C	C	1570757	3	2	295	1	0	0	0	0	1	0	0	0	7595	1551	54	5	902	5	IFT140	16	1570757	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08		1570757	88783996	290	54661											
PKMYT1	9088	broad.mit.edu	37	chr16	3024069	3024069	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaactgcagggtggtgagccAggcggggtggctggcgggcc	6	5	21	9	2	0	1	0	1	0	0	0	1	0	1	2	8	3	2	2	8	1	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:3024069A>T	uc002csn.2	-	7	1685	c.1242T>A	c.(1240-1242)CCT>CCA	p.P414P	PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_Silent_p.P414P|PKMYT1_uc002cso.2_Silent_p.P345P|PKMYT1_uc002csp.2_Silent_p.P405P|PKMYT1_uc002csq.2_Silent_p.P405P|PKMYT1_uc010bsy.1_Silent_p.P405P	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	414	Interaction with PIN1.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1						GTGGTGAGCCAGGCGGGGTGG	0.677													6	19					0	0	0	0	T	3024069	T	T	3024069	2	4	295	1	0	0	0	0	0	0	0	1	12033	175	7	5		5	PKMYT1	16	3024069	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	1453312	3024069	87330684	291	54662											
GRIN2A	2903	broad.mit.edu	37	chr16	9857816	9857816	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcactgtgcggggaacccttGtctttcaaggtgaagtgctt	7	13	12	9	1	3	1	2	1	1	0	3	2	3	2	1	3	3	1	1	3	3	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:9857816G>T	uc002czo.3	-	13	4133	c.3585C>A	c.(3583-3585)GAC>GAA	p.D1195E	GRIN2A_uc010uym.1_Missense_Mutation_p.D1195E|GRIN2A_uc010uyn.1_Missense_Mutation_p.D1038E|GRIN2A_uc002czr.3_Missense_Mutation_p.D1195E	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1195	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGGAACCCTTGTCTTTCAAGG	0.532													62	223					3.89499e-28	5.68974e-28	1	0	T	9857816	T	T	9857816	3	4	295	1	0	0	0	0	1	0	0	0	6818	1368	48	4	813	4	GRIN2A	16	9857816	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	6833747	9857816	80496937	292	54663											
XYLT1	64131	broad.mit.edu	37	chr16	17211771	17211771	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcatacccaccggctcatcCatgggccccagaagaccccc	9	5	8	19	1	1	2	1	0	0	2	2	2	2	2	7	2	2	2	7	2	2	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:17211771C>A	uc002dfa.2	-	11	2374	c.2289G>T	c.(2287-2289)ATG>ATT	p.M763I		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	763	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CCGGCTCATCCATGGGCCCCA	0.572													14	42					1.3612e-06	1.52114e-06	1	0	A	17211771	A	A	17211771	3	1	295	1	0	0	0	0	1	0	0	0	17531	594	21	4	598	4	XYLT1	16	17211771	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	7353955	17211771	73142982	293	54664											
ACSM3	6296	broad.mit.edu	37	chr16	20793102	20793103	+	Frame_Shift_Ins	INS	-	C	C																															aatgcttgtacagaatgataINStaaccaggtaagaaatgtta																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:20793102_20793103insC	uc002dhr.2	+	7	1199_1200	c.1012_1013insC	c.(1012-1014)ATAfs	p.I338fs	ACSM3_uc002dhq.2_Frame_Shift_Ins_p.I338fs|ACSM3_uc010vba.1_Frame_Shift_Ins_p.I367fs|ERI2_uc002dhs.2_Intron	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	338					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						ACAGAATGATATAACCAGGTAA	0.406													---	---	---								C	20793103	C	C	20793102	7	5	295	1	0	1	1	0	0	0	0	0	185	449	16	0	1034	0	ACSM3	16	20793102	Frame_Shift_Ins	INS	-	TCGA-F7-7848-01A-11D-2129-08	3581331	20793102	69561651	294	54665											
SCNN1B	6338	broad.mit.edu	37	chr16	23391744	23391744	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctccctgttccccacagatCgtctggctgctctcgaatct	5	12	8	16	2	3	1	0	0	3	1	7	2	5	1	3	1	1	4	3	1	1	1	rs61759916	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:23391744C>T	uc002dln.2	+	13	1721	c.1545C>T	c.(1543-1545)ATC>ATT	p.I515I		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	515	Helical; (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	CCCCACAGATCGTCTGGCTGC	0.582													28	74					0	0	0	0	T	23391744	T	T	23391744	2	4	295	1	0	0	0	0	0	0	0	1	13993	874	31	1		1	SCNN1B	16	23391744	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2598642	23391744	66963009	295	54666											
PALB2	79728	broad.mit.edu	37	chr16	23640992	23640992	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgtttatgcagctcctggCatgtgtttctacagagctga	9	14	10	8	0	1	2	0	1	1	1	2	2	2	2	1	1	4	6	1	1	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:23640992C>A	uc002dlx.1	-	5	2683	c.2483G>T	c.(2482-2484)TGC>TTC	p.C828F		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	828					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		CAGCTCCTGGCATGTGTTTCT	0.438			F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				17	51					6.49762e-13	8.44313e-13	1	0	A	23640992	A	A	23640992	3	1	295	1	0	0	0	0	1	0	0	0	11460	710	25	4	1113	4	PALB2	16	23640992	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	249248	23640992	66713761	296	54667											
RBBP6	5930	broad.mit.edu	37	chr16	24578538	24578538	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcactaccagcaactccagTctttgtacctgttccaccac	9	11	5	16	0	2	0	1	0	1	0	4	0	4	0	5	0	4	3	5	0	3	4	rs16973840		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:24578538T>G	uc002dmh.2	+	15	2704	c.1664T>G	c.(1663-1665)GTC>GGC	p.V555G	RBBP6_uc010vcb.1_Missense_Mutation_p.V422G|RBBP6_uc002dmi.2_Missense_Mutation_p.V555G|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.V422G	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	555					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GCAACTCCAGTCTTTGTAcct	0.239													16	47					0	0	0	0	G	24578538	G	G	24578538	3	3	295	1	0	0	0	0	1	0	0	0	13168	1667	58	5	1776	5	RBBP6	16	24578538	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	937546	24578538	65776215	297	54668											
ATP2A1	487	broad.mit.edu	37	chr16	28895897	28895897	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttccctactctctccacagtGggggacaaagtccctgcaga	9	9	9	14	0	1	1	0	0	1	1	5	2	4	2	3	2	2	1	3	2	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:28895897G>T	uc002dro.1	+	6	649	c.465G>T	c.(463-465)GTG>GTT	p.V155V	uc010vct.1_Intron|ATP2A1_uc002drn.1_Silent_p.V155V|ATP2A1_uc002drp.1_Silent_p.V30V	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	155	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCTCCACAGTGGGGGACAAAG	0.532													14	36					8.60227e-14	1.13764e-13	1	0	T	28895897	T	T	28895897	2	4	295	1	0	0	0	0	0	0	0	1	1138	1362	47	4		4	ATP2A1	16	28895897	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	4317359	28895897	61458856	298	54669											
SETD1A	9739	broad.mit.edu	37	chr16	30977521	30977521	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gaggaggcccggctgccaccCagggaagaagcagagctggc	10	2	17	12	1	0	2	0	0	0	2	0	5	0	4	3	5	3	3	3	5	2	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:30977521C>T	uc002ead.1	+	8	3005	c.2319C>T	c.(2317-2319)CCC>CCT	p.P773P		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	773					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						GGCTGCCACCCAGGGAAGAAG	0.667													8	40					0	0	0	0	T	30977521	T	T	30977521	2	4	295	1	0	0	0	0	0	0	0	1	14195	581	21	4		4	SETD1A	16	30977521	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2081624	30977521	59377232	299	54670											
STX4	6810	broad.mit.edu	37	chr16	31045834	31045834	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgagatcaaacagctggggaGggagatccgcctgcagctga	11	6	15	9	1	1	3	1	2	0	2	2	6	2	4	2	3	4	3	2	3	1	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:31045834G>T	uc002eal.2	+	4	508	c.284G>T	c.(283-285)AGG>ATG	p.R95M	STX4_uc002eak.2_Missense_Mutation_p.R93M|STX4_uc002eam.2_Missense_Mutation_p.R17M	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	95	Cytoplasmic (Potential).|Potential.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						CAGCTGGGGAGGGAGATCCGC	0.383													8	20					0.00307968	0.00317925	1	0	T	31045834	T	T	31045834	3	4	295	1	0	0	0	0	1	0	0	0	15413	1000	35	4	298	4	STX4	16	31045834	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	68313	31045834	59308919	300	54671											
ABCC12	94160	broad.mit.edu	37	chr16	48119591	48119591	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccattttctgtgacttctgcCtgtaatttttctgggagttt	5	20	8	8	0	3	1	0	1	3	0	3	2	3	2	2	1	1	2	2	1	1	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:48119591C>A	uc002efc.1	-	27	4087	c.3741G>T	c.(3739-3741)CAG>CAT	p.Q1247H	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	1247	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TGACTTCTGCCTGTAATTTTT	0.403													31	53					1.08312e-15	1.45392e-15	1	0	A	48119591	A	A	48119591	3	1	295	1	0	0	0	0	1	0	0	0	52	680	24	4	350	4	ABCC12	16	48119591	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	17073757	48119591	42235162	301	54672											
HSF4	3299	broad.mit.edu	37	chr16	67201122	67201122	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggacccctacttcatccaGtcggtaggtttgtcttcttc	6	14	8	13	1	3	0	1	0	2	0	6	1	4	1	3	3	1	2	3	3	2	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:67201122G>A	uc002erl.1	+	9	1691	c.726G>A	c.(724-726)CAG>CAA	p.Q242Q	HSF4_uc002erm.1_Silent_p.Q242Q|HSF4_uc002ern.1_RNA|HSF4_uc010cec.1_RNA	NM_001040667	NP_001035757	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4 isoform b	242					response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		ACTTCATCCAGTCGGTAGGTT	0.567													18	39					0	0	0	0	A	67201122	A	A	67201122	2	1	295	1	0	0	0	0	0	0	0	1	7437	1020	36	4		4	HSF4	16	67201122	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	19081531	67201122	23153631	302	54673											
MPHOSPH6	10200	broad.mit.edu	37	chr16	82182435	82182435	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tggtctctctttctggcaaaCtttttcccaattgtccccac	6	16	5	14	0	3	0	0	0	3	0	6	0	5	0	3	2	1	1	3	2	2	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:82182435C>G	uc002fgw.2	-	5	433	c.384G>C	c.(382-384)AAG>AAC	p.K128N		NM_005792	NP_005783	Q99547	MPH6_HUMAN	M-phase phosphoprotein 6	128	Nuclear localization signal (Potential).				M phase of mitotic cell cycle|maturation of 5.8S rRNA	cytoplasm|nucleolus	protein binding|RNA binding				0						TTCTGGCAAACTTTTTCCCAA	0.398													40	85					0	0	0	0	G	82182435	G	G	82182435	3	3	295	1	0	0	0	0	1	0	0	0	9779	564	20	4	102	4	MPHOSPH6	16	82182435	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	14981313	82182435	8172318	303	54674											
MYBBP1A	10514	broad.mit.edu	37	chr17	4443014	4443014	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggctggactcttggtggttGgcgtcccgtttgcctgggct	1	13	17	10	2	1	0	0	0	1	0	2	1	2	1	2	6	1	4	2	6	0	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:4443014G>C	uc002fyb.3	-	26	3745	c.3683C>G	c.(3682-3684)CCA>CGA	p.P1228R	MYBBP1A_uc002fxz.3_Missense_Mutation_p.P1228R|SPNS2_uc002fxx.2_3'UTR|SPNS2_uc002fxy.2_3'UTR|MYBBP1A_uc002fya.3_Missense_Mutation_p.P173R|MYBBP1A_uc010vsa.1_Missense_Mutation_p.P270R	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	1228	Required for nuclear and nucleolar localization (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						CTTGGTGGTTGGCGTCCCGTT	0.652													33	117					0	0	0	0	C	4443014	C	C	4443014	3	2	295	1	0	0	0	0	1	0	0	0	10061	1348	47	4	347	4	MYBBP1A	17	4443014	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08		4443014	76752196	304	54675											
BCL6B	255877	broad.mit.edu	37	chr17	6927486	6927486	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggggtcccgaagcgagaggCttcgcccctctattggactt	6	9	14	12	3	1	1	0	0	1	1	3	4	2	2	3	4	1	1	3	4	2	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:6927486C>G	uc002geg.2	+	3	321	c.264C>G	c.(262-264)GGC>GGG	p.G88G	BCL6B_uc010clt.1_Silent_p.G88G	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	88	BTB.					nucleus	zinc ion binding			skin(1)	1						AAGCGAGAGGCTTCGCCCCTC	0.612													66	143					0	0	0	0	G	6927486	G	G	6927486	2	3	295	1	0	0	0	0	0	0	0	1	1379	784	28	4		4	BCL6B	17	6927486	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2484472	6927486	74267724	305	54676											
POLR2A	5430	broad.mit.edu	37	chr17	7399318	7399318	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agagacgactgagggaggccGccccaagcttggggggctga	9	4	18	10	2	0	3	0	2	0	1	0	6	0	4	3	5	1	2	3	5	1	1	rs150809300		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:7399318G>C	uc002ghf.3	+	2	386	c.152G>C	c.(151-153)CGC>CCC	p.R51P	POLR2A_uc002ghe.2_Missense_Mutation_p.R51P	NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	51					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				GAGGGAGGCCGCCCCAAGCTT	0.592													26	73					0	0	0	0	C	7399318	C	C	7399318	3	2	295	1	0	0	0	0	1	0	0	0	12269	1087	38	3	158	3	POLR2A	17	7399318	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	471832	7399318	73795892	306	54677											
TP53	7157	broad.mit.edu	37	chr17	7577081	7577081	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttcttgcggagattctctTcctctgtgcgccggtctctc	2	16	9	14	3	4	1	0	0	4	1	8	2	5	1	2	2	2	0	2	2	0	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:7577081T>A	uc002gim.2	-	8	1051	c.857A>T	c.(856-858)GAA>GTA	p.E286V	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E286V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E154V|TP53_uc010cng.1_Missense_Mutation_p.E154V|TP53_uc002gii.1_Missense_Mutation_p.E154V|TP53_uc010cnh.1_Missense_Mutation_p.E286V|TP53_uc010cni.1_Missense_Mutation_p.E286V|TP53_uc002gij.2_Missense_Mutation_p.E286V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	286	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> G (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E286K(50)|p.E286*(14)|p.E286G(14)|p.0?(7)|p.E286V(6)|p.E286Q(5)|p.?(2)|p.E286D(2)|p.E286E(2)|p.R283fs*16(2)|p.E286fs*59(2)|p.E286fs*17(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.E286A(1)|p.V272_K292del21(1)|p.E285_L289delEEENL(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGATTCTCTTCCTCTGTGCG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	63					0	0	0	0	A	7577081	A	A	7577081	3	1	295	1	0	0	0	0	1	0	0	0	16448	1783	62	5	429	5	TP53	17	7577081	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	177763	7577081	73618129	307	54678											
TP53	7157	broad.mit.edu	37	chr17	7579514	7579514	+	Frame_Shift_Del	DEL	G	-	-																															tgggagcttcatctggacctGggtcttcagtgaaccattgt																								rs144386518		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:7579514delG	uc002gim.2	-	4	367	c.173delC	c.(172-174)CCAfs	p.P58fs	TP53_uc002gig.1_Frame_Shift_Del_p.P58fs|TP53_uc002gih.2_Frame_Shift_Del_p.P58fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.P58fs|TP53_uc010cni.1_Frame_Shift_Del_p.P58fs|TP53_uc002gij.2_Frame_Shift_Del_p.P58fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.P19fs|TP53_uc010cnk.1_Frame_Shift_Del_p.P73fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	58	Interaction with HRMT1L2.		P -> T (in a sporadic cancer; somatic mutation).|P -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.P58L(1)|p.P58fs*65(1)|p.E51fs*59(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)|p.D57fs*86(1)|p.P58Q(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCTGGACCTGGGTCTTCAGT	0.602		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								-	7579514	-	-	7579514	7	5	295	1	0	1	0	1	0	0	0	0	16448	1348	47	0	1129	0	TP53	17	7579514	Frame_Shift_Del	DEL	G	TCGA-F7-7848-01A-11D-2129-08	2433	7579514	73615696	308	54679											
MYH2	4620	broad.mit.edu	37	chr17	10432120	10432120	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgcaggttgtcaatctgctCcccaagctcggccacactat	8	10	8	15	1	2	0	1	0	1	0	4	0	3	0	3	2	3	4	3	2	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:10432120C>A	uc010coi.2	-	27	3759	c.3631G>T	c.(3631-3633)GAG>TAG	p.E1211*	uc002gml.1_Intron|MYH2_uc002gmp.3_Nonsense_Mutation_p.E1211*|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1211	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCAATCTGCTCCCCAAGCTCG	0.537													24	81					3.01185e-09	3.65841e-09	1	0	A	10432120	A	A	10432120	4	1	295	1	0	0	0	0	0	1	0	0	10088	864	30	2	2250	2	MYH2	17	10432120	Nonsense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	2852606	10432120	70763090	309	54680											
SLC47A1	55244	broad.mit.edu	37	chr17	19480696	19480697	+	Missense_Mutation	DNP	CC	AA	AA																															atgttggaaagacaggcgagCctcagtcagatcagcagatg																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:19480696_19480697CC>AA	uc002gvy.1	+	17	1629_1630	c.1543_1544CC>AA	c.(1543-1545)CCT>AAT	p.P515N	SLC47A1_uc002gvx.2_Missense_Mutation_p.P515N|SLC47A1_uc010vyz.1_3'UTR|SLC47A1_uc010cqp.1_Missense_Mutation_p.P213N|SLC47A1_uc010cqq.1_Missense_Mutation_p.P261N|SLC47A1_uc010vza.1_Missense_Mutation_p.P227N|SLC47A1_uc010vzb.1_Missense_Mutation_p.P190N|SLC47A1_uc010vzc.1_Missense_Mutation_p.P187N	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	515	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					GACAGGCGAGCCTCAGTCAGAT	0.495													41	110					0	0	0	0	AA	19480697	AA	AA	19480696	3	1	295	1	0	0	0	0	1	0	0	0	14711	739	26	4	1609	4	SLC47A1	17	19480696	Missense_Mutation	DNP	CC	TCGA-F7-7848-01A-11D-2129-08	9048576	19480696	61714514	310	54681											
KCNJ12	3768	broad.mit.edu	37	chr17	21319644	21319644	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggtcaccgctttgagcccgtGctcttcgaggagaagaacca	9	8	12	12	3	2	3	1	1	1	2	3	5	2	3	3	2	3	2	3	2	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:21319644G>T	uc002gyv.1	+	3	1695	c.990G>T	c.(988-990)GTG>GTT	p.V330V		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	330	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TTGAGCCCGTGCTCTTCGAGG	0.587										Prostate(3;0.18)			30	211					9.78306e-22	1.40161e-21	1	0	T	21319644	T	T	21319644	2	4	295	1	0	0	0	0	0	0	0	1	8085	1306	46	4		4	KCNJ12	17	21319644	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1838948	21319644	59875566	311	54682											
ABCA10	10349	broad.mit.edu	37	chr17	67148622	67148622	+	Frame_Shift_Del	DEL	C	-	-																															acggtagcctgaagtatctgCctaaagataaagtaagggat																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:67148622delC	uc010dfa.1	-	36	5016	c.4137delG	c.(4135-4137)TGGfs	p.W1379fs	ABCA10_uc002jhz.2_5'Flank|ABCA10_uc010wqs.1_Frame_Shift_Del_p.W371fs|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1379	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GAAGTATCTGCCTAAAGATAA	0.403													---	---	---								-	67148622	-	-	67148622	7	5	295	1	0	1	0	1	0	0	0	0	29	753	26	0	514	0	ABCA10	17	67148622	Frame_Shift_Del	DEL	C	TCGA-F7-7848-01A-11D-2129-08	45828978	67148622	14046588	312	54683											
FOXK2	3607	broad.mit.edu	37	chr17	80477969	80477969	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggctcggtggacgtgagcAtgggccactcgagcttcatc	7	8	15	11	3	1	1	1	1	0	0	4	3	1	2	1	4	2	3	1	4	0	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:80477969A>C	uc002kfn.2	+	1	376	c.205A>C	c.(205-207)ATG>CTG	p.M69L	FOXK2_uc002kfm.1_Missense_Mutation_p.M69L|FOXK2_uc010diu.2_Missense_Mutation_p.M69L	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	69	FHA.|Gly-rich.			AAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGR EFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFT PPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG -> Q (in Ref. 1; CAA43200).	embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			GGACGTGAGCATGGGCCACTC	0.478													4	40					0	0	0	0	C	80477969	C	C	80477969	3	2	295	1	0	0	0	0	1	0	0	0	6049	217	8	5	207	5	FOXK2	17	80477969	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	13329347	80477969	717241	313	54684											
TMEM200C	645369	broad.mit.edu	37	chr18	5891793	5891793	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggtggctgctgcccgcaggCggcagctgcttacccccctc	3	7	13	18	3	0	0	0	0	0	0	1	0	0	0	4	4	5	6	4	4	1	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr18:5891793C>G	uc002kmx.1	-	1	311	c.270G>C	c.(268-270)CCG>CCC	p.P90P		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	90						integral to membrane					0						TGCCCGCAGGCGGCAGCTGCT	0.672													26	26					0	0	0	0	G	5891793	G	G	5891793	2	3	295	1	0	0	0	0	0	0	0	1	16191	755	27	3		3	TMEM200C	18	5891793	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08		5891793	72185455	314	54685											
PTPRM	5797	broad.mit.edu	37	chr18	7955363	7955363	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgaccaggccaggggagggTggcactggctctcctggtcc	5	7	16	13	0	1	1	0	1	1	0	3	2	2	2	4	7	0	2	4	7	0	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr18:7955363T>A	uc002knn.3	+	7	1586	c.1083T>A	c.(1081-1083)GGT>GGA	p.G361G	PTPRM_uc010dkv.2_Silent_p.G361G|PTPRM_uc010wzl.1_Silent_p.G148G	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	361	Fibronectin type-III 1.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CAGGGGAGGGTGGCACTGGCT	0.498													28	22					0	0	0	0	A	7955363	A	A	7955363	2	1	295	1	0	0	0	0	0	0	0	1	12871	1683	59	5		5	PTPRM	18	7955363	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	2063570	7955363	70121885	315	54686											
C18orf55	29090	broad.mit.edu	37	chr18	71816193	71816193	+	Missense_Mutation	SNP	A	C	C																															gggcttcaatatcaaaagaaAacgctgcgacctagatgtat																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr18:71816193A>C	uc010dqr.1	+	1	448	c.150A>C	c.(148-150)AAA>AAC	p.K50N	FBXO15_uc002lle.2_5'Flank|FBXO15_uc002llf.2_5'Flank	NM_014177	NP_054896	Q9BVV7	TI21L_HUMAN	hypothetical protein LOC29090 precursor	50					protein transport|transmembrane transport	integral to membrane|mitochondrial membrane					0		Esophageal squamous(42;0.0746)|Prostate(75;0.157)|Melanoma(33;0.211)				ATCAAAAGAAAACGCTGCGAC	0.498													50	135					0	0	0	0	C	71816193	C	C	71816193	3	2	295	1	0	0	0	0	1	0	0	0	1914	11	1	5	152	5	C18orf55	18	71816193	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	63860830	71816193	6261055	316	54687	128	2									
C18orf55	29090	broad.mit.edu	37	chr18	71816197	71816197	+	Missense_Mutation	SNP	C	G	G																															ttcaatatcaaaagaaaacgCtgcgacctagatgtattctt																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr18:71816197C>G	uc010dqr.1	+	1	452	c.154C>G	c.(154-156)CTG>GTG	p.L52V	FBXO15_uc002lle.2_5'Flank|FBXO15_uc002llf.2_5'Flank	NM_014177	NP_054896	Q9BVV7	TI21L_HUMAN	hypothetical protein LOC29090 precursor	52					protein transport|transmembrane transport	integral to membrane|mitochondrial membrane					0		Esophageal squamous(42;0.0746)|Prostate(75;0.157)|Melanoma(33;0.211)				AAAGAAAACGCTGCGACCTAG	0.493													56	135					0	0	0	0	G	71816197	G	G	71816197	3	3	295	1	0	0	0	0	1	0	0	0	1914	796	28	4	156	4	C18orf55	18	71816197	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	4	71816197	6261051	317	54688	128	2									
CELF5	60680	broad.mit.edu	37	chr19	3282450	3282450	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtgccctttccaggtgggcaCcctgccctggaaaccgtcta	6	9	11	15	1	1	0	0	0	1	0	2	1	2	1	5	3	3	1	5	3	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:3282450C>A	uc002lxm.2	+	8	1030	c.993C>A	c.(991-993)CAC>CAA	p.H331Q	CELF5_uc002lxl.1_Missense_Mutation_p.H331Q|CELF5_uc010dtj.1_Missense_Mutation_p.H306Q|CELF5_uc010xhg.1_Missense_Mutation_p.H217Q|CELF5_uc002lxn.2_RNA	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	331					mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						CAGGTGGGCACCCTGCCCTGG	0.622													13	57					1.49906e-05	1.63434e-05	1	0	A	3282450	A	A	3282450	3	1	295	1	0	0	0	0	1	0	0	0	3234	506	18	4	1023	4	CELF5	19	3282450	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08		3282450	55846533	318	54689											
TMEM146	257062	broad.mit.edu	37	chr19	5776299	5776299	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	caatggcttttatgtcttctAcatttcgatcgtggatccgt	7	17	8	9	3	2	0	0	0	2	0	5	2	3	1	1	2	1	1	1	2	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:5776299A>G	uc002mda.2	+	21	2130	c.2069A>G	c.(2068-2070)TAC>TGC	p.Y690C		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	690	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TATGTCTTCTACATTTCGATC	0.577													23	30					0	0	0	0	G	5776299	G	G	5776299	3	3	295	1	0	0	0	0	1	0	0	0	16126	391	14	5	2151	5	TMEM146	19	5776299	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	2493849	5776299	53352684	319	54690											
FUT6	2528	broad.mit.edu	37	chr19	5831891	5831891	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtctccatcatggttccctGgggcaggggcttgtgggagc	4	10	16	11	1	2	0	1	0	1	0	4	1	3	1	2	6	1	3	2	6	0	2	rs364637	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:5831891G>T	uc002mdf.1	-	4	1214	c.688C>A	c.(688-690)CAG>AAG	p.Q230K	FUT6_uc002mdg.1_Missense_Mutation_p.Q230K|FUT6_uc002mdh.1_Missense_Mutation_p.Q230K|FUT6_uc010dul.1_Missense_Mutation_p.Q230K	NM_001040701	NP_001035791	P51993	FUT6_HUMAN	fucosyltransferase 6	230	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						ATGGTTCCCTGGGGCAGGGGC	0.612													18	99					1.7881e-09	2.18383e-09	1	0	T	5831891	T	T	5831891	3	4	295	1	0	0	0	0	1	0	0	0	6142	1357	47	4	395	4	FUT6	19	5831891	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	55592	5831891	53297092	320	54691											
ZNF440	126070	broad.mit.edu	37	chr19	11943503	11943503	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gttccagttccttttgatatCatgaaaggactcacactgga	11	13	8	9	0	2	2	2	2	0	0	4	4	4	4	2	2	0	2	2	2	2	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:11943503C>G	uc002msp.1	+	4	1668	c.1512C>G	c.(1510-1512)ATC>ATG	p.I504M		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTTTGATATCATGAAAGGAC	0.423													10	29					0	0	0	0	G	11943503	G	G	11943503	3	3	295	1	0	0	0	0	1	0	0	0	17980	816	29	2	1526	2	ZNF440	19	11943503	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	6111612	11943503	47185480	321	54692											
ZNF440	126070	broad.mit.edu	37	chr19	11943668	11943668	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatctgccccacacctttgaAtacgtggtaggacacacaat	12	9	8	12	1	1	1	0	1	1	0	1	3	1	2	3	2	2	1	3	2	4	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:11943668A>G	uc002msp.1	+	4	1833	c.1677A>G	c.(1675-1677)GAA>GAG	p.E559E		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACACCTTTGAATACGTGGTAG	0.478													6	47					0	0	0	0	G	11943668	G	G	11943668	2	3	295	1	0	0	0	0	0	0	0	1	17980	98	4	5		5	ZNF440	19	11943668	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	165	11943668	47185315	322	54693											
ZNF700	90592	broad.mit.edu	37	chr19	12060260	12060260	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatactggagagaaaccctAtgaatgtaaggaatgtggga	15	9	12	5	0	1	2	1	1	0	1	1	6	1	5	1	3	2	1	1	3	6	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:12060260A>T	uc002msu.2	+	4	1547	c.1421A>T	c.(1420-1422)TAT>TTT	p.Y474F	ZNF700_uc010xme.1_Missense_Mutation_p.Y492F|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	474	C2H2-type 10; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAAACCCTATGAATGTAAG	0.433													17	59					0	0	0	0	T	12060260	T	T	12060260	3	4	295	1	0	0	0	0	1	0	0	0	18171	449	16	5	1435	5	ZNF700	19	12060260	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	116592	12060260	47068723	323	54694											
BEST2	54831	broad.mit.edu	37	chr19	12867030	12867030	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acttgtactgggatgcagccGaggctcgcgccccatacaca	9	7	11	14	3	0	0	0	0	0	0	1	2	0	1	3	2	4	3	3	2	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:12867030G>A	uc002mux.2	+	8	1024	c.1024G>A	c.(1024-1026)GAG>AAG	p.E342K		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	342	Cytoplasmic (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						GGATGCAGCCGAGGCTCGCGC	0.592													34	158					0	0	0	0	A	12867030	A	A	12867030	3	1	295	1	0	0	0	0	1	0	0	0	1407	1059	37	1	1054	1	BEST2	19	12867030	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	806770	12867030	46261953	324	54695											
NACC1	112939	broad.mit.edu	37	chr19	13247186	13247186	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	accccaagctctacgacgagGgcgacccctctgagaagctg	10	5	11	15	3	2	1	0	1	2	1	2	5	2	1	4	1	3	2	4	1	3	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:13247186G>T	uc002mwm.2	+	3	1255	c.1087G>T	c.(1087-1089)GGC>TGC	p.G363C		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	363					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						CTACGACGAGGGCGACCCCTC	0.647													22	53					1.66031e-10	2.06155e-10	1	0	T	13247186	T	T	13247186	3	4	295	1	0	0	0	0	1	0	0	0	10188	1232	43	4	1093	4	NACC1	19	13247186	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	380156	13247186	45881797	325	54696											
F2RL3	9002	broad.mit.edu	37	chr19	17000980	17000980	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgacgcgctgcccctggacGcacaggcctcccactggcaa	8	5	11	17	3	0	1	0	1	0	0	1	2	1	2	4	3	1	3	4	3	1	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:17000980G>T	uc002nfa.2	+	2	881	c.706G>T	c.(706-708)GCA>TCA	p.A236S		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	236	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						GCCCCTGGACGCACAGGCCTC	0.706													3	12					0.00909568	0.00930382	1	0	T	17000980	T	T	17000980	3	4	295	1	0	0	0	0	1	0	0	0	5371	1087	38	3	712	3	F2RL3	19	17000980	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3753794	17000980	42128003	326	54697											
KIRREL2	84063	broad.mit.edu	37	chr19	36351814	36351814	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tagtctctttcgtccagttgGgccgattctgcaggcaaagc	7	12	11	11	2	2	0	0	0	2	0	5	1	3	0	2	2	2	3	2	2	2	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:36351814G>C	uc002ocb.3	+	8	1144	c.932G>C	c.(931-933)GGG>GCG	p.G311A	KIRREL2_uc002obz.3_Missense_Mutation_p.G311A|KIRREL2_uc002oca.3_Missense_Mutation_p.G261A|KIRREL2_uc002occ.3_Missense_Mutation_p.G258A|KIRREL2_uc002ocd.3_Missense_Mutation_p.G308A	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	311	Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGTCCAGTTGGGCCGATTCTG	0.652													7	23					0	0	0	0	C	36351814	C	C	36351814	3	2	295	1	0	0	0	0	1	0	0	0	8364	1232	43	4	962	4	KIRREL2	19	36351814	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	19350834	36351814	22777169	327	54698											
ZNF780B	163131	broad.mit.edu	37	chr19	40542336	40542336	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcatttcttcatagctgaTgatcttctggttgatatatc	9	17	8	7	0	4	3	1	3	3	0	5	3	4	3	0	2	1	3	0	2	3	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:40542336T>C	uc002omu.2	-	5	495	c.430A>G	c.(430-432)ATC>GTC	p.I144V	ZNF780B_uc002omv.2_5'UTR	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCATAGCTGATGATCTTCTGG	0.373													8	26					0	0	0	0	C	40542336	C	C	40542336	3	2	295	1	0	0	0	0	1	0	0	0	18220	1464	51	5	2075	5	ZNF780B	19	40542336	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	4190522	40542336	18586647	328	54699											
SPTBN4	57731	broad.mit.edu	37	chr19	40978616	40978616	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccgctgggagagtccggatCggggctgggagcgggagcag	6	4	21	10	4	0	1	0	0	0	1	2	5	1	4	2	6	2	3	2	6	0	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:40978616C>T	uc002ony.2	+	2	174	c.88C>T	c.(88-90)CGG>TGG	p.R30W	SPTBN4_uc002onx.2_Missense_Mutation_p.R30W|SPTBN4_uc002onz.2_Missense_Mutation_p.R30W	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	30	Actin-binding.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAGTCCGGATCGGGGCTGGGA	0.667													5	19					0	0	0	0	T	40978616	T	T	40978616	3	4	295	1	0	0	0	0	1	0	0	0	15187	875	31	1	90	1	SPTBN4	19	40978616	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	436280	40978616	18150367	329	54700											
DMRTC2	63946	broad.mit.edu	37	chr19	42354396	42354396	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctagacactcaactctgataCtccagccctgtggcacccca	10	8	6	17	0	2	2	1	1	1	1	3	2	3	2	4	1	3	1	4	1	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:42354396C>T	uc002ors.2	+	7	855	c.772C>T	c.(772-774)CTC>TTC	p.L258F	DMRTC2_uc002orr.1_Missense_Mutation_p.L135F|DMRTC2_uc010xwe.1_Missense_Mutation_p.L258F	NM_001040283	NP_001035373	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	258	Pro-rich.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						AACTCTGATACTCCAGCCCTG	0.537													86	284					0	0	0	0	T	42354396	T	T	42354396	3	4	295	1	0	0	0	0	1	0	0	0	4613	565	20	4	794	4	DMRTC2	19	42354396	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	1375780	42354396	16774587	330	54701											
QPCTL	54814	broad.mit.edu	37	chr19	46205167	46205167	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgaccacatccccttcctccGcagaggtaccagctgcaggg	8	6	10	17	2	0	1	0	0	0	1	3	2	3	1	6	2	3	4	6	2	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:46205167G>A	uc010xxr.1	+	6	1219	c.998G>A	c.(997-999)CGC>CAC	p.R333H	QPCTL_uc010ekn.2_Missense_Mutation_p.R239H	NM_017659	NP_060129	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like isoform	333					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		CCCTTCCTCCGCAGAGGTACC	0.592													10	61					0	0	0	0	A	46205167	A	A	46205167	3	1	295	1	0	0	0	0	1	0	0	0	12940	1087	38	1	1020	1	QPCTL	19	46205167	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	3850771	46205167	12923816	331	54702											
NLRP12	91662	broad.mit.edu	37	chr19	54304538	54304538	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctcacacagcagcagcaccCcgaggtcccccagctcattc	9	5	7	20	1	2	0	2	0	0	0	4	1	3	0	5	1	4	4	5	1	0	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:54304538C>A	uc002qch.3	-	7	2919	c.2699G>T	c.(2698-2700)GGG>GTG	p.G900V	NLRP12_uc010eqw.2_Missense_Mutation_p.G183V|NLRP12_uc002qci.3_Missense_Mutation_p.G900V|NLRP12_uc002qcj.3_Missense_Mutation_p.G901V|NLRP12_uc002qck.3_Intron|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	900	LRR 3.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CAGCAGCACCCCGAGGTCCCC	0.622													12	36					7.03913e-09	8.43563e-09	1	0	A	54304538	A	A	54304538	3	1	295	1	0	0	0	0	1	0	0	0	10528	623	22	4	502	4	NLRP12	19	54304538	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	8099371	54304538	4824445	332	54703											
MBOAT7	79143	broad.mit.edu	37	chr19	54692190	54692190	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcggctgctccccatctcttCagcccaggacctgcaggggg	5	7	13	16	1	2	0	1	0	1	0	4	1	3	1	4	4	3	3	4	4	0	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:54692190C>T	uc002qdq.2	-	4	353	c.87G>A	c.(85-87)CTG>CTA	p.L29L	MBOAT7_uc010erg.2_5'Flank|MBOAT7_uc010yem.1_Silent_p.L11L|MBOAT7_uc002qdr.2_Silent_p.L29L|MBOAT7_uc002qds.2_5'UTR|MBOAT7_uc010yen.1_5'UTR|MBOAT7_uc002qdt.3_Silent_p.L29L|TSEN34_uc010yeo.1_5'Flank|TSEN34_uc002qdu.2_5'Flank|TSEN34_uc002qdv.2_5'Flank|TSEN34_uc002qdw.2_5'Flank	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	29	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCCATCTCTTCAGCCCAGGAC	0.642													9	18					0	0	0	0	T	54692190	T	T	54692190	2	4	295	1	0	0	0	0	0	0	0	1	9411	813	29	2		2	MBOAT7	19	54692190	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	387652	54692190	4436793	333	54704											
NLRP7	199713	broad.mit.edu	37	chr19	55446005	55446005	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaattcagcccactgctccgGggtggcacagtgacctccca	8	7	11	15	1	1	1	1	1	0	0	3	2	3	1	4	3	2	2	4	3	1	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:55446005G>T	uc002qih.3	-	7	2399	c.2323C>A	c.(2323-2325)CCG>ACG	p.P775T	NLRP7_uc002qig.3_Missense_Mutation_p.P747T|NLRP7_uc002qii.3_Missense_Mutation_p.P775T|NLRP7_uc010esk.2_Missense_Mutation_p.P775T|NLRP7_uc010esl.2_Missense_Mutation_p.P803T	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	775	LRR 3.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CACTGCTCCGGGGTGGCACAG	0.478													13	32					0.000219431	0.000234655	1	0	T	55446005	T	T	55446005	3	4	295	1	0	0	0	0	1	0	0	0	10536	1232	43	4	810	4	NLRP7	19	55446005	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	753815	55446005	3682978	334	54705											
UBE2S	27338	broad.mit.edu	37	chr19	55915802	55915802	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggcagggaagtccttccccaGcaggagtttcatgcggaaca	10	7	13	11	1	1	0	1	0	0	0	3	3	3	3	3	4	3	3	3	4	2	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:55915802G>A	uc002qkx.1	-	3	564	c.196C>T	c.(196-198)CTG>TTG	p.L66L		NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	66					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		TCCTTCCCCAGCAGGAGTTTC	0.612													11	18					0	0	0	0	A	55915802	A	A	55915802	2	1	295	1	0	0	0	0	0	0	0	1	16940	962	34	4		4	UBE2S	19	55915802	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	469797	55915802	3213181	335	54706											
NLRP8	126205	broad.mit.edu	37	chr19	56459511	56459511	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	caggtcgagacagccagctgGgcagaggtggttcatctctt	8	9	14	10	1	2	2	1	0	1	2	4	3	2	2	1	4	2	3	1	4	0	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:56459511G>T	uc002qmh.2	+	1	314	c.243G>T	c.(241-243)TGG>TGT	p.W81C	NLRP8_uc010etg.2_Missense_Mutation_p.W81C	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	81	DAPIN.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CAGCCAGCTGGGCAGAGGTGG	0.522													8	22					0.000157383	0.000168706	1	0	T	56459511	T	T	56459511	3	4	295	1	0	0	0	0	1	0	0	0	10537	1241	43	4	245	4	NLRP8	19	56459511	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	543709	56459511	2669472	336	54707											
ZNF582	147948	broad.mit.edu	37	chr19	56901748	56901748	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgagatcaccttacccagTgagaccaggttgctgtaggt	10	9	12	10	1	1	2	1	1	0	2	1	5	1	2	3	2	2	3	3	2	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:56901748T>C	uc002qmz.1	-	3	291	c.132A>G	c.(130-132)TCA>TCG	p.S44S	ZNF582_uc002qmy.2_Silent_p.S75S	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	44	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		CCTTACCCAGTGAGACCAGGT	0.488													28	90					0	0	0	0	C	56901748	C	C	56901748	2	2	295	1	0	0	0	0	0	0	0	1	18081	1683	59	5		5	ZNF582	19	56901748	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	442237	56901748	2227235	337	54708											
PEG3	5178	broad.mit.edu	37	chr19	57327096	57327096	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctccaggaacacttttcTgaggtttggcacggaataca	10	11	9	11	1	2	1	0	1	2	0	3	3	2	3	2	4	2	2	2	4	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:57327096T>A	uc002qnu.2	-	7	3065	c.2714A>T	c.(2713-2715)CAG>CTG	p.Q905L	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.Q876L|PEG3_uc002qnv.2_Missense_Mutation_p.Q905L|PEG3_uc002qnw.2_Missense_Mutation_p.Q781L|PEG3_uc002qnx.2_Missense_Mutation_p.Q779L|PEG3_uc010etr.2_Missense_Mutation_p.Q905L	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	905					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AACACTTTTCTGAGGTTTGGC	0.478													13	73					0	0	0	0	A	57327096	A	A	57327096	3	1	295	1	0	0	0	0	1	0	0	0	11774	1580	55	5	2056	5	PEG3	19	57327096	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	425348	57327096	1801887	338	54709											
ZIM3	114026	broad.mit.edu	37	chr19	57646302	57646302	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcctatctggagtgaattCttttctggtgcctaacaagg	8	14	10	9	0	3	1	0	1	3	0	4	2	4	2	2	3	2	1	2	3	4	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:57646302C>A	uc002qnz.1	-	5	1789	c.1403G>T	c.(1402-1404)AGA>ATA	p.R468I		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	468	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGAGTGAATTCTTTTCTGGTG	0.423													26	85					3.99451e-17	5.49399e-17	1	0	A	57646302	A	A	57646302	3	1	295	1	0	0	0	0	1	0	0	0	17752	913	32	2	19	2	ZIM3	19	57646302	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	319206	57646302	1482681	339	54710											
ZNF543	125919	broad.mit.edu	37	chr19	57828948	57828948	+	5'Flank	DEL	C	-	-																															catcctcctccccgcggccgCcgcctagtcctcaagccgct																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:57828948delC	uc002qoi.1	+							NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CCCGCGGCCGCCGCCTAGTCC	0.637													---	---	---								-	57828948	-	-	57828948	6	5	295	0	1	1	0	1	0	0	0	0	18043	754	26	0		0	ZNF543	19	57828948	5'Flank	DEL	C	TCGA-F7-7848-01A-11D-2129-08	182646	57828948	1300035	340	54711											
ZNF530	348327	broad.mit.edu	37	chr19	58117342	58117342	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaagctctttaaagtggatgGggaccaggcctcatttatga	11	11	12	7	0	2	1	1	1	1	0	2	4	2	3	2	4	1	1	2	4	4	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:58117342G>T	uc002qpk.2	+	3	669	c.449G>T	c.(448-450)GGG>GTG	p.G150V	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAAGTGGATGGGGACCAGGCC	0.473													14	54					1.5842e-08	1.87835e-08	1	0	T	58117342	T	T	58117342	3	4	295	1	0	0	0	0	1	0	0	0	18038	1232	43	4	459	4	ZNF530	19	58117342	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	288394	58117342	1011641	341	54712											
ZNF329	79673	broad.mit.edu	37	chr19	58639938	58639938	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ttacatctatatggtttttcCcctgtatgagttctttggtg	6	20	8	7	0	2	1	0	1	2	0	3	1	3	1	2	2	1	3	2	2	4	8			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:58639938C>G	uc002qrn.2	-	4	1170	c.933G>C	c.(931-933)GGG>GGC	p.G311G	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		ATGGTTTTTCCCCTGTATGAG	0.433													41	108					0	0	0	0	G	58639938	G	G	58639938	2	3	295	1	0	0	0	0	0	0	0	1	17914	610	22	4		4	ZNF329	19	58639938	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	522596	58639938	489045	342	54713											
SIRPA	140885	broad.mit.edu	37	chr20	1918052	1918052	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcggagcccaacaaccacacGgagtatgccagcattcagac	13	4	10	14	2	1	1	1	0	0	1	1	3	1	3	3	2	5	2	3	2	3	2	rs149536101	by1000genomes	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:1918052G>T	uc002wfq.2	+	9	1713	c.1353G>T	c.(1351-1353)ACG>ACT	p.T451T	SIRPA_uc010zps.1_Silent_p.T431T|SIRPA_uc002wfr.2_Silent_p.T451T|SIRPA_uc002wfs.2_Silent_p.T451T|SIRPA_uc002wft.2_Silent_p.T455T	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	451	Cytoplasmic (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		ACAACCACACGGAGTATGCCA	0.582													17	61					3.32936e-07	3.76765e-07	1	0	T	1918052	T	T	1918052	2	4	295	1	0	0	0	0	0	0	0	1	14397	1103	39	3		3	SIRPA	20	1918052	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08		1918052	61107468	343	54714											
C20orf26	26074	broad.mit.edu	37	chr20	20177327	20177327	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gccctcaaccccattttccgGcactacaccaagttctttct	8	12	4	17	1	3	0	1	0	2	0	4	0	4	0	5	1	2	2	5	1	3	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:20177327G>A	uc002wru.2	+	16	1780	c.1704G>A	c.(1702-1704)CGG>CGA	p.R568R	C20orf26_uc010zse.1_Silent_p.R548R	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	568										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCATTTTCCGGCACTACACCA	0.468													53	69					0	0	0	0	A	20177327	A	A	20177327	2	1	295	1	0	0	0	0	0	0	0	1	2116	1190	42	4		4	C20orf26	20	20177327	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	18259275	20177327	42848193	344	54715											
SUN5	140732	broad.mit.edu	37	chr20	31590391	31590392	+	Splice_Site	DEL	AC	-	-																															tgattattcagtatatacgtAcacacacatcccagcatgca																										TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:31590391_31590392delAC	uc002wyi.2	-	3	304	c.211_splice	c.e3+1	p.S71_splice		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like						spermatogenesis					skin(1)	1						GTATATACGTACACACACATCC	0.554													---	---	---								-	31590392	-	-	31590391	8	5	295	1	0	1	0	1	0	0	1	0	15460	405	14	0	970	0	SUN5	20	31590391	Splice_Site	DEL	AC	TCGA-F7-7848-01A-11D-2129-08	11413064	31590391	31435129	345	54716											
KIAA1755	85449	broad.mit.edu	37	chr20	36869162	36869162	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggggaggaggtgtttctgctAgggcagggcatgggcttggg	5	9	22	5	0	1	0	0	0	1	0	1	2	1	2	0	8	1	5	0	8	1	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:36869162A>G	uc002xhy.1	-	3	1643	c.1371T>C	c.(1369-1371)CCT>CCC	p.P457P	KIAA1755_uc002xhz.1_Silent_p.P457P	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	457										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				TGTTTCTGCTAGGGCAGGGCA	0.572													21	70					0	0	0	0	G	36869162	G	G	36869162	2	3	295	1	0	0	0	0	0	0	0	1	8296	407	15	5		5	KIAA1755	20	36869162	Silent	SNP	A	TCGA-F7-7848-01A-11D-2129-08	5278771	36869162	26156358	346	54717											
ZFP64	55734	broad.mit.edu	37	chr20	50776766	50776766	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccgagtggatcctcaggtgcTtgttgaggctgctgctgtcg	4	12	15	10	2	1	1	1	1	0	0	3	3	2	2	2	3	3	5	2	3	0	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:50776766T>C	uc002xwl.2	-	5	1008	c.659A>G	c.(658-660)AAG>AGG	p.K220R	ZFP64_uc002xwk.2_Missense_Mutation_p.K220R|ZFP64_uc002xwm.2_Missense_Mutation_p.K218R|ZFP64_uc002xwn.2_Missense_Mutation_p.K166R	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	220	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CCTCAGGTGCTTGTTGAGGCT	0.597													45	115					0	0	0	0	C	50776766	C	C	50776766	3	2	295	1	0	0	0	0	1	0	0	0	17719	1609	56	5	2585	5	ZFP64	20	50776766	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	13907604	50776766	12248754	347	54718											
ZNF217	7764	broad.mit.edu	37	chr20	52198454	52198454	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tggcaaatggcaacttttccTttggtagccagctgccaagc	9	11	10	11	0	0	0	0	0	0	0	1	0	1	0	3	3	5	4	3	3	4	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:52198454T>A	uc002xwq.3	-	1	1183	c.912A>T	c.(910-912)AAA>AAT	p.K304N	ZNF217_uc010gij.1_Missense_Mutation_p.K296N	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	304					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CAACTTTTCCTTTGGTAGCCA	0.517													57	128					0	0	0	0	A	52198454	A	A	52198454	3	1	295	1	0	0	0	0	1	0	0	0	17839	1606	56	5	2250	5	ZNF217	20	52198454	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	1421688	52198454	10827066	348	54719											
BCAS1	8537	broad.mit.edu	37	chr20	52612559	52612559	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atccgcagttccaagttcttGtccttctttttccttgccgt	4	18	6	13	2	2	0	0	0	2	0	6	0	6	0	5	0	1	3	5	0	1	7			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:52612559G>T	uc002xws.2	-	5	1092	c.754C>A	c.(754-756)CAA>AAA	p.Q252K	BCAS1_uc010zza.1_5'UTR|BCAS1_uc010zzb.1_Missense_Mutation_p.Q155K|BCAS1_uc010gim.2_Missense_Mutation_p.Q155K|BCAS1_uc002xwt.2_Missense_Mutation_p.Q252K|BCAS1_uc010gil.1_Missense_Mutation_p.Q252K	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	252						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CCAAGTTCTTGTCCTTCTTTT	0.473													20	60					7.41877e-09	8.86682e-09	1	0	T	52612559	T	T	52612559	3	4	295	1	0	0	0	0	1	0	0	0	1352	1386	48	4	1032	4	BCAS1	20	52612559	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	414105	52612559	10412961	349	54720											
PRIC285	85441	broad.mit.edu	37	chr20	62191627	62191627	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttgtagggcgtgaggacggcGatgtcctggggctctacggt	5	10	18	8	4	1	1	0	1	1	0	2	3	2	2	1	6	1	2	1	6	2	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:62191627G>A	uc002yfm.2	-	18	8446	c.7554C>T	c.(7552-7554)ATC>ATT	p.I2518I	PRIC285_uc002yfl.1_Silent_p.I1949I	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	2518					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TGAGGACGGCGATGTCCTGGG	0.672													4	7					0	0	0	0	A	62191627	A	A	62191627	2	1	295	1	0	0	0	0	0	0	0	1	12547	1048	37	1		1	PRIC285	20	62191627	Silent	SNP	G	TCGA-F7-7848-01A-11D-2129-08	9579068	62191627	833893	350	54721											
MORC3	23515	broad.mit.edu	37	chr21	37741308	37741308	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgaaacggagactttctactCgttcctcaattttgaatgca	11	14	7	9	2	2	3	1	2	1	1	4	4	3	3	1	1	3	2	1	1	4	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr21:37741308C>G	uc002yvi.2	+	15	1718	c.1642C>G	c.(1642-1644)CGT>GGT	p.R548G		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	548					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						ACTTTCTACTCGTTCCTCAAT	0.299													9	23					0	0	0	0	G	37741308	G	G	37741308	3	3	295	1	0	0	0	0	1	0	0	0	9756	884	31	3	1700	3	MORC3	21	37741308	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08		37741308	10388587	351	54722											
HPS4	89781	broad.mit.edu	37	chr22	26873050	26873050	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagaaatgtcagaaacacagCggacaactccagcaatctgt	16	6	8	11	1	2	2	1	0	1	2	3	3	3	3	1	1	4	1	1	1	4	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr22:26873050C>A	uc003acl.2	-	4	844	c.185G>T	c.(184-186)CGC>CTC	p.R62L	HPS4_uc003aci.2_Missense_Mutation_p.R57L|HPS4_uc003acj.2_5'UTR|HPS4_uc003ack.2_5'UTR|HPS4_uc003acn.2_5'UTR|HPS4_uc010gvd.1_Missense_Mutation_p.R62L|HPS4_uc003aco.1_Missense_Mutation_p.R57L	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	62					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						AGAAACACAGCGGACAACTCC	0.443									Hermansky-Pudlak_syndrome				17	48					2.23348e-06	2.47734e-06	1	0	A	26873050	A	A	26873050	3	1	295	1	0	0	0	0	1	0	0	0	7380	768	27	3	1985	3	HPS4	22	26873050	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08		26873050	24431516	352	54723											
SLC5A4	6527	broad.mit.edu	37	chr22	32643427	32643427	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caaaaccacacagatgaagaGggagaggatggagaggtaga	18	3	15	5	0	0	6	0	1	0	5	0	9	0	7	1	4	1	1	1	4	4	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr22:32643427G>T	uc003ami.2	-	5	450	c.448C>A	c.(448-450)CTC>ATC	p.L150I		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	150	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CAGATGAAGAGGGAGAGGATG	0.498													10	41					7.48243e-07	8.40363e-07	1	0	T	32643427	T	T	32643427	3	4	295	1	0	0	0	0	1	0	0	0	14731	1000	35	4	1575	4	SLC5A4	22	32643427	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	5770377	32643427	18661139	353	54724											
GRAMD4	23151	broad.mit.edu	37	chr22	47062734	47062734	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcgccagggggtggcggatAcagtggagcatcgtgcccga	7	7	17	10	4	0	0	0	0	0	0	2	3	0	2	2	5	3	1	2	5	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr22:47062734A>G	uc003bhx.2	+	9	861	c.822A>G	c.(820-822)ATA>ATG	p.I274M	GRAMD4_uc010had.2_Missense_Mutation_p.I213M	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	274					apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		GGTGGCGGATACAGTGGAGCA	0.622													35	90					0	0	0	0	G	47062734	G	G	47062734	3	3	295	1	0	0	0	0	1	0	0	0	6791	381	14	5	856	5	GRAMD4	22	47062734	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	14419307	47062734	4241832	354	54725											
SBF1	6305	broad.mit.edu	37	chr22	50893510	50893510	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aacggcgggacacatggtggTagccgaggaacttgaggtag	11	6	17	7	3	0	1	0	1	0	0	0	4	0	3	1	6	3	2	1	6	4	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr22:50893510T>C	uc003blh.2	-	34	4811	c.4616A>G	c.(4615-4617)TAC>TGC	p.Y1539C	SBF1_uc003ble.2_Missense_Mutation_p.Y15C|SBF1_uc003blf.2_Missense_Mutation_p.Y15C|SBF1_uc011arx.1_Missense_Mutation_p.Y1177C	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1513	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CACATGGTGGTAGCCGAGGAA	0.622													16	34					0	0	0	0	C	50893510	C	C	50893510	3	2	295	1	0	0	0	0	1	0	0	0	13923	1638	57	5	1097	5	SBF1	22	50893510	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	3830776	50893510	411056	355	54726											
IL1RAPL1	11141	broad.mit.edu	37	chrX	28807464	28807464	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttaagagctggaagatgAaagctccgattccacacttg	12	10	9	10	1	0	3	0	1	0	2	2	5	2	4	3	1	2	2	3	1	3	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:28807464A>T	uc004dby.2	+	2	512	c.4A>T	c.(4-6)AAA>TAA	p.K2*		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	2					innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						CTGGAAGATGAAAGCTCCGAT	0.348													13	13					0	0	0	0	T	28807464	T	T	28807464	4	4	295	1	0	0	0	0	0	1	0	0	7700	247	9	5	6	5	IL1RAPL1	23	28807464	Nonsense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08		28807464	126463096	356	54727											
CXorf21	80231	broad.mit.edu	37	chrX	30577959	30577959	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggggaaagtcactgggctGagtagaaatggaatcctcca	12	9	13	7	0	1	2	1	1	0	1	3	4	3	4	2	4	0	2	2	4	4	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:30577959G>T	uc004dcg.1	-	3	790	c.514C>A	c.(514-516)CAG>AAG	p.Q172K		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	172										ovary(1)	1						TCACTGGGCTGAGTAGAAATG	0.428													24	21					3.08376e-08	3.58037e-08	1	0	T	30577959	T	T	30577959	3	4	295	1	0	0	0	0	1	0	0	0	4118	1299	45	2	395	2	CXorf21	23	30577959	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	1770495	30577959	124692601	357	54728											
DMD	1756	broad.mit.edu	37	chrX	31496420	31496420	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggttcaatttttcccactCagtattgacctcctcagcct	8	14	5	14	0	3	1	3	1	0	0	5	1	5	1	4	1	1	2	4	1	2	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:31496420C>G	uc004dda.1	-	59	8984	c.8740G>C	c.(8740-8742)GAG>CAG	p.E2914Q	DMD_uc004dcq.1_Missense_Mutation_p.E185Q|DMD_uc004dcr.1_Missense_Mutation_p.E454Q|DMD_uc004dcs.1_Missense_Mutation_p.E454Q|DMD_uc004dct.1_Missense_Mutation_p.E454Q|DMD_uc004dcu.1_Missense_Mutation_p.E454Q|DMD_uc004dcv.1_Missense_Mutation_p.E454Q|DMD_uc004dcw.2_Missense_Mutation_p.E1570Q|DMD_uc004dcx.2_Missense_Mutation_p.E1573Q|DMD_uc004dcz.2_Missense_Mutation_p.E2791Q|DMD_uc004dcy.1_Missense_Mutation_p.E2910Q|DMD_uc004ddb.1_Missense_Mutation_p.E2906Q	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2914	Spectrin 21.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTTTCCCACTCAGTATTGACC	0.498													18	23					0	0	0	0	G	31496420	G	G	31496420	3	3	295	1	0	0	0	0	1	0	0	0	4602	835	29	2	2515	2	DMD	23	31496420	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	918461	31496420	123774140	358	54729											
DMD	1756	broad.mit.edu	37	chrX	32519917	32519917	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgagctgatctgctggcatCttgcagttttctgaacttct	6	16	9	10	0	4	3	0	3	4	0	4	3	4	3	0	1	4	5	0	1	1	4			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:32519917C>A	uc004dda.1	-	19	2579	c.2335G>T	c.(2335-2337)GAT>TAT	p.D779Y	DMD_uc004dcz.2_Missense_Mutation_p.D656Y|DMD_uc004dcy.1_Missense_Mutation_p.D775Y|DMD_uc004ddb.1_Missense_Mutation_p.D771Y|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	779	Spectrin 4.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTGCTGGCATCTTGCAGTTTT	0.413													6	3					8.12818e-05	8.77608e-05	1	0	A	32519917	A	A	32519917	3	1	295	1	0	0	0	0	1	0	0	0	4602	913	32	2	9209	2	DMD	23	32519917	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	1023497	32519917	122750643	359	54730											
CXorf22	170063	broad.mit.edu	37	chrX	35993268	35993268	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttcattttttttcagggccTtctgtccttaactttggtaa	6	21	6	8	0	3	0	2	0	1	0	4	0	4	0	2	2	1	1	2	2	2	9			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:35993268T>G	uc004ddj.2	+	14	2318	c.2259T>G	c.(2257-2259)CCT>CCG	p.P753P	CXorf22_uc010ngv.2_Intron	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	753										large_intestine(1)|lung(1)|ovary(1)	3						TTTCAGGGCCTTCTGTCCTTA	0.284													23	27					0	0	0	0	G	35993268	G	G	35993268	2	3	295	1	0	0	0	0	0	0	0	1	4119	1596	56	5		5	CXorf22	23	35993268	Silent	SNP	T	TCGA-F7-7848-01A-11D-2129-08	3473351	35993268	119277292	360	54731											
ITIH5L	347365	broad.mit.edu	37	chrX	54785330	54785330	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccccatccgtcaggaagaTgataagagggatcctcccca	11	7	9	14	1	1	3	1	1	0	2	5	5	5	5	6	2	0	0	6	2	2	1			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:54785330T>C	uc004dtj.2	-	8	1207	c.1177A>G	c.(1177-1179)ATC>GTC	p.I393V		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	393	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GTCAGGAAGATGATAAGAGGG	0.612													11	6					0	0	0	0	C	54785330	C	C	54785330	3	2	295	1	0	0	0	0	1	0	0	0	7947	1464	51	5	2788	5	ITIH5L	23	54785330	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	18792062	54785330	100485230	361	54732											
KLF8	11279	broad.mit.edu	37	chrX	56310806	56310806	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaatttgctcgctcagatgAgctcactcgccatttccgca	9	11	8	13	3	2	2	2	1	0	1	5	3	3	2	2	0	2	4	2	0	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:56310806A>T	uc004dur.2	+	6	1905	c.959A>T	c.(958-960)GAG>GTG	p.E320V	KLF8_uc011mop.1_3'UTR|KLF8_uc010nkh.2_RNA	NM_007250	NP_009181	O95600	KLF8_HUMAN	Kruppel-like factor 8 isoform 1	320	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CGCTCAGATGAGCTCACTCGC	0.498													4	6					0	0	0	0	T	56310806	T	T	56310806	3	4	295	1	0	0	0	0	1	0	0	0	8391	304	11	5	981	5	KLF8	23	56310806	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	1525476	56310806	98959754	362	54733											
TEX11	56159	broad.mit.edu	37	chrX	70026595	70026595	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcatatttattattcttctGggtttctactccaaagttgt	8	21	5	7	0	4	0	1	0	3	0	5	0	5	0	1	1	1	2	1	1	5	10			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:70026595G>T	uc004dyl.2	-	10	859	c.697C>A	c.(697-699)CAG>AAG	p.Q233K	TEX11_uc004dym.2_Missense_Mutation_p.Q218K	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	233							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					TTATTCTTCTGGGTTTCTACT	0.303													3	5					0.00024832	0.000264914	1	0	T	70026595	T	T	70026595	3	4	295	1	0	0	0	0	1	0	0	0	15840	1357	47	4	2213	4	TEX11	23	70026595	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	13715789	70026595	85243965	363	54734											
MED12	9968	broad.mit.edu	37	chrX	70345277	70345277	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagcagcgagatgatgcccGccatgccatcaagaaaatca	16	5	9	11	2	2	3	2	1	0	2	2	4	2	3	3	0	4	1	3	0	4	0			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:70345277G>T	uc004dyy.2	+	16	2502	c.2303G>T	c.(2302-2304)CGC>CTC	p.R768L	MED12_uc011mpq.1_Missense_Mutation_p.R768L|MED12_uc004dyz.2_Missense_Mutation_p.R768L|MED12_uc004dza.2_Missense_Mutation_p.R615L	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	768					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GATGATGCCCGCCATGCCATC	0.532													12	8					5.50884e-06	6.05025e-06	1	0	T	70345277	T	T	70345277	3	4	295	1	0	0	0	0	1	0	0	0	9481	1087	38	3	2365	3	MED12	23	70345277	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	318682	70345277	84925283	364	54735											
MED12	9968	broad.mit.edu	37	chrX	70353025	70353025	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgattgcaaaccaaagcAgcttatgcatgaggcactca	15	8	9	9	0	1	3	1	2	0	1	1	3	1	3	1	1	5	5	1	1	3	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:70353025A>G	uc004dyy.2	+	33	4779	c.4580A>G	c.(4579-4581)CAG>CGG	p.Q1527R	MED12_uc011mpq.1_Missense_Mutation_p.Q1527R|MED12_uc004dyz.2_Missense_Mutation_p.Q1527R|MED12_uc004dza.2_Missense_Mutation_p.Q1374R|MED12_uc010nla.2_Missense_Mutation_p.Q153R	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1527					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					AAACCAAAGCAGCTTATGCAT	0.463													30	34					0	0	0	0	G	70353025	G	G	70353025	3	3	295	1	0	0	0	0	1	0	0	0	9481	188	7	5	4710	5	MED12	23	70353025	Missense_Mutation	SNP	A	TCGA-F7-7848-01A-11D-2129-08	7748	70353025	84917535	365	54736											
MORF4L2	9643	broad.mit.edu	37	chrX	102931678	102931678	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccgagggggctgaggtgctTcgctggtactgccaccatct	5	10	14	12	2	1	1	0	1	1	0	3	2	2	1	3	4	3	4	3	4	1	2			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:102931678T>A	uc004ekw.2	-	4	1510	c.278A>T	c.(277-279)GAA>GTA	p.E93V	MORF4L2_uc004ela.2_Missense_Mutation_p.E93V|MORF4L2_uc004ekx.2_Missense_Mutation_p.E93V|MORF4L2_uc004elb.2_Missense_Mutation_p.E93V|MORF4L2_uc004eky.2_Missense_Mutation_p.E93V|MORF4L2_uc010nos.2_Missense_Mutation_p.E93V|MORF4L2_uc004ekz.2_Missense_Mutation_p.E93V|MORF4L2_uc011mry.1_Missense_Mutation_p.E93V|MORF4L2_uc011mrz.1_Missense_Mutation_p.E93V|MORF4L2_uc004elc.2_Missense_Mutation_p.E93V|MORF4L2_uc004elf.2_Missense_Mutation_p.E93V|MORF4L2_uc004ele.2_Missense_Mutation_p.E93V|MORF4L2_uc011msa.1_Missense_Mutation_p.E93V|MORF4L2_uc011msb.1_Missense_Mutation_p.E93V|MORF4L2_uc011msc.1_Missense_Mutation_p.E93V|MORF4L2_uc011msd.1_Missense_Mutation_p.E93V|MORF4L2_uc004eld.2_Missense_Mutation_p.E93V	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	93					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						CTGAGGTGCTTCGCTGGTACT	0.542													31	31					0	0	0	0	A	102931678	A	A	102931678	3	1	295	1	0	0	0	0	1	0	0	0	9760	1783	62	5	592	5	MORF4L2	23	102931678	Missense_Mutation	SNP	T	TCGA-F7-7848-01A-11D-2129-08	32578653	102931678	52338882	366	54737											
NRK	203447	broad.mit.edu	37	chrX	105168850	105168850	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggagatcaggaagaacatGcagccaatataggcagtgaa	16	7	12	6	0	1	3	1	1	0	2	1	5	1	4	1	3	3	2	1	3	6	3			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:105168850G>T	uc004emd.2	+	19	3442	c.3139G>T	c.(3139-3141)GCA>TCA	p.A1047S	NRK_uc010npc.1_Missense_Mutation_p.A715S	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1047							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GGAAGAACATGCAGCCAATAT	0.517										HNSCC(51;0.14)			9	10					3.09899e-07	3.51585e-07	1	0	T	105168850	T	T	105168850	3	4	295	1	0	0	0	0	1	0	0	0	10709	1319	46	4	3213	4	NRK	23	105168850	Missense_Mutation	SNP	G	TCGA-F7-7848-01A-11D-2129-08	2237172	105168850	50101710	367	54738											
ODZ1	10178	broad.mit.edu	37	chrX	123630881	123630881	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttaccttaattccaaaataCtaacggagtttcccgaggga	13	11	7	10	2	0	0	0	0	0	0	2	3	2	2	3	2	3	1	3	2	6	6			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:123630881C>T	uc004euj.2	-	20	3744	c.3680G>A	c.(3679-3681)AGT>AAT	p.S1227N	ODZ1_uc011muj.1_Missense_Mutation_p.S1226N|ODZ1_uc010nqy.2_Missense_Mutation_p.S1227N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1227	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTCCAAAATACTAACGGAGTT	0.398													15	16					0	0	0	0	T	123630881	T	T	123630881	3	4	295	1	0	0	0	0	1	0	0	0	10888	565	20	4	4570	4	ODZ1	23	123630881	Missense_Mutation	SNP	C	TCGA-F7-7848-01A-11D-2129-08	18462031	123630881	31639679	368	54739											
CDR1	1038	broad.mit.edu	37	chrX	139865920	139865920	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttccggaaaaaatccaggtCttccagccaatatatgtctt	12	12	6	11	1	2	0	0	0	2	0	5	1	5	1	4	2	1	0	4	2	6	5			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:139865920C>T	uc004fbg.1	-	1	804	c.612G>A	c.(610-612)AAG>AAA	p.K204K	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	204	5.|5 X 6 AA approximate repeats.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				AAATCCAGGTCTTCCAGCCAA	0.448													56	39					0	0	0	0	T	139865920	T	T	139865920	2	4	295	1	0	0	0	0	0	0	0	1	3186	912	32	2		2	CDR1	23	139865920	Silent	SNP	C	TCGA-F7-7848-01A-11D-2129-08	16235039	139865920	15404640	369	54740											
KIF17	57576	broad.mit.edu	37	chr1	21031194	21031194	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagcagccgcgtcagcttcGagtcacggtaggggacgtgc	7	6	16	12	5	2	0	2	0	0	0	3	2	2	1	1	3	4	4	1	3	1	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:21031194G>A	uc001bdr.3	-	5	987	c.869C>T	c.(868-870)TCG>TTG	p.S290L	KIF17_uc001bds.3_Missense_Mutation_p.S290L	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	290					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CGTCAGCTTCGAGTCACGGTA	0.622													16	44					0	0	0	0	A	21031194	A	A	21031194	3	1	296	1	0	0	0	0	1	0	0	0	8318	1059	37	1	2264	1	KIF17	1	21031194	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08		21031194	228219427	1	54741											
COL16A1	1307	broad.mit.edu	37	chr1	32148956	32148956	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tgaatgccaggcaaacccggGgctccaggctccccctgcaa	9	5	11	16	1	0	1	0	1	0	0	2	1	2	1	5	4	3	4	5	4	3	0			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:32148956G>A	uc001btk.1	-	35	2759	c.2394C>T	c.(2392-2394)GCC>GCT	p.A798A	COL16A1_uc001btj.1_Silent_p.A627A|COL16A1_uc001btl.3_Silent_p.A798A	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	798	Triple-helical region 5 (COL5) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GCAAACCCGGGGCTCCAGGCT	0.617													45	141					0	0	0	0	A	32148956	A	A	32148956	2	1	296	1	0	0	0	0	0	0	0	1	3688	1219	43	4		4	COL16A1	1	32148956	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	11117762	32148956	217101665	2	54742											
CELSR2	1952	broad.mit.edu	37	chr1	109795883	109795883	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatatctcagatagtctgaCttacagctttgagcggggaa	11	12	11	7	1	2	4	1	3	2	1	3	5	2	5	0	2	3	1	0	2	4	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:109795883C>T	uc001dxa.3	+	1	3243	c.3182C>T	c.(3181-3183)ACT>ATT	p.T1061I		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1061	Cadherin 9.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GATAGTCTGACTTACAGCTTT	0.547													16	43					0	0	0	0	T	109795883	T	T	109795883	3	4	296	1	0	0	0	0	1	0	0	0	3237	565	20	4	3184	4	CELSR2	1	109795883	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	77646927	109795883	139454738	3	54743											
WDR77	79084	broad.mit.edu	37	chr1	111985333	111985333	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtacagctgagctcaggaCacagcttgtactcttggtgt	8	12	12	9	0	2	1	1	1	1	0	2	2	2	2	0	2	5	5	0	2	2	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:111985333C>T	uc001ebb.2	-	8	781	c.742G>A	c.(742-744)GTC>ATC	p.V248I	WDR77_uc010owd.1_RNA|WDR77_uc010owe.1_Missense_Mutation_p.V184I	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	248	WD 4.				ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		GAGCTCAGGACACAGCTTGTA	0.443													5	19					0	0	0	0	T	111985333	T	T	111985333	3	4	296	1	0	0	0	0	1	0	0	0	17395	478	17	4	298	4	WDR77	1	111985333	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	2189450	111985333	137265288	4	54744											
PDE4DIP	9659	broad.mit.edu	37	chr1	145075708	145075708	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccggctggctccgggcgcCgtctttcccggctcggggtc	0	9	15	17	6	1	0	0	0	1	0	6	0	4	0	4	6	0	3	4	6	0	1	rs148346797	byFrequency	TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:145075708C>T	uc001emh.2	-	1	372	c.155G>A	c.(154-156)CGG>CAG	p.R52Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Missense_Mutation_p.R52Q|PDE4DIP_uc001emk.2_Missense_Mutation_p.R52Q	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTCCGGGCGCCGTCTTTCCCG	0.721			T	PDGFRB	MPD								13	82					0	0	0	0	T	145075708	T	T	145075708	3	4	296	1	0	0	0	0	1	0	0	0	11697	652	23	1	8657	1	PDE4DIP	1	145075708	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	33090375	145075708	104174913	5	54745											
VHLL	391104	broad.mit.edu	37	chr1	156268971	156268971	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccaccccgttccccgctcTccagggcattacctccgaag	7	7	7	20	3	1	0	0	0	1	0	4	1	3	0	8	1	1	3	8	1	2	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:156268971T>G	uc001fok.2	-	1	458	c.10A>C	c.(10-12)AGA>CGA	p.R4R		NM_001004319	NP_001004319	Q6RSH7	VHLL_HUMAN	von Hippel-Lindau tumor suppressor-like	4					protein ubiquitination	nucleus				ovary(1)	1	Hepatocellular(266;0.158)					TTCCCCGCTCTCCAGGGCATT	0.592													22	79					0	0	0	0	G	156268971	G	G	156268971	2	3	296	1	0	0	0	0	0	0	0	1	17231	1559	54	5		5	VHLL	1	156268971	Silent	SNP	T	TCGA-H7-7774-01A-21D-2078-08	11193263	156268971	92981650	6	54746											
KIRREL	55243	broad.mit.edu	37	chr1	158047906	158047906	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggaggccgccctgcgctctCggcgggccaaactcaccgtg	5	5	14	17	6	2	0	1	0	1	0	3	1	2	1	4	4	2	1	4	4	1	0			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:158047906C>T	uc001frn.3	+	3	732	c.328C>T	c.(328-330)CGG>TGG	p.R110W	KIRREL_uc010pib.1_Intron|KIRREL_uc009wsq.2_Missense_Mutation_p.R49W	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	110	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CCTGCGCTCTCGGCGGGCCAA	0.607													9	117					0	0	0	0	T	158047906	T	T	158047906	3	4	296	1	0	0	0	0	1	0	0	0	8363	875	31	1	338	1	KIRREL	1	158047906	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	1778935	158047906	91202715	7	54747											
OR10X1	128367	broad.mit.edu	37	chr1	158549570	158549570	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaccacaaaaagaaatgtCtgtacatgtgggtacacaga	18	7	9	7	0	1	3	0	0	1	3	1	3	1	3	1	1	2	2	1	1	6	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:158549570C>T	uc010pin.1	-	1	120	c.120G>A	c.(118-120)CAG>CAA	p.Q40Q		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	40	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AAAGAAATGTCTGTACATGTG	0.423													6	78					0	0	0	0	T	158549570	T	T	158549570	2	4	296	1	0	0	0	0	0	0	0	1	10976	912	32	2		2	OR10X1	1	158549570	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	501664	158549570	90701051	8	54748											
FMO1	2326	broad.mit.edu	37	chr1	171250015	171250015	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggtgttcatgacacgctttCagaacatgttgagaaattcc	11	13	9	8	1	2	3	2	2	0	2	3	4	3	3	1	1	1	3	1	1	2	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:171250015C>G	uc009wvz.2	+	6	854	c.718C>G	c.(718-720)CAG>GAG	p.Q240E	FMO1_uc010pme.1_Missense_Mutation_p.Q177E|FMO1_uc001ghl.2_Missense_Mutation_p.Q240E|FMO1_uc001ghm.2_Missense_Mutation_p.Q240E|FMO1_uc001ghn.2_Missense_Mutation_p.Q240E	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	240					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GACACGCTTTCAGAACATGTT	0.493													7	68					0	0	0	0	G	171250015	G	G	171250015	3	3	296	1	0	0	0	0	1	0	0	0	5986	827	29	2	736	2	FMO1	1	171250015	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	12700445	171250015	78000606	9	54749											
CEP350	9857	broad.mit.edu	37	chr1	180080243	180080243	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaccctgatcaaagatactAttgatgttctgaatcagatc	14	12	7	8	0	3	6	2	3	1	3	4	6	3	6	1	0	1	1	1	0	4	4	rs150197968		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:180080243A>G	uc001gnt.2	+	38	9684	c.9301A>G	c.(9301-9303)ATT>GTT	p.I3101V	CEP350_uc009wxl.2_Missense_Mutation_p.I3100V|CEP350_uc001gnv.2_Missense_Mutation_p.I1236V|CEP350_uc001gnw.1_Missense_Mutation_p.I858V|CEP350_uc001gnx.1_Missense_Mutation_p.I858V	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	3101						centrosome|nucleus|spindle				ovary(4)	4						CAAAGATACTATTGATGTTCT	0.463													15	29					0	0	0	0	G	180080243	G	G	180080243	3	3	296	1	0	0	0	0	1	0	0	0	3269	449	16	5	9447	5	CEP350	1	180080243	Missense_Mutation	SNP	A	TCGA-H7-7774-01A-21D-2078-08	8830228	180080243	69170378	10	54750											
PPFIA4	8497	broad.mit.edu	37	chr1	203013095	203013095	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagtgcctggtgtcccgcCatgaacggtcactgcggatg	6	9	15	11	3	1	1	1	1	0	0	2	3	2	3	3	4	3	0	3	4	1	0			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:203013095C>T	uc009xaj.2	+	8	814	c.814C>T	c.(814-816)CAT>TAT	p.H272Y	PPFIA4_uc010pqf.1_5'Flank			O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GGTGTCCCGCCATGAACGGTC	0.622													8	31					0	0	0	0	T	203013095	T	T	203013095	3	4	296	1	0	0	0	0	1	0	0	0	12367	609	21	4		4	PPFIA4	1	203013095	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	22932852	203013095	46237526	11	54751											
FCAMR	83953	broad.mit.edu	37	chr1	207135705	207135705	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaagtctgtgagggccacacGgtcacgatagcgatggtgag	11	7	15	8	3	2	2	1	2	1	0	2	4	2	2	1	3	1	0	1	3	2	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:207135705G>A	uc001hfa.3	-	5	1005	c.505C>T	c.(505-507)CGT>TGT	p.R169C	FCAMR_uc001hfb.2_Missense_Mutation_p.R169C|FCAMR_uc009xca.1_Missense_Mutation_p.R169C|FCAMR_uc001hfc.2_Missense_Mutation_p.R144C	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	124	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						AGGGCCACACGGTCACGATAG	0.572													28	41					0	0	0	0	A	207135705	A	A	207135705	3	1	296	1	0	0	0	0	1	0	0	0	5804	1116	39	1	1244	1	FCAMR	1	207135705	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	4122610	207135705	42114916	12	54752											
GPR137B	7107	broad.mit.edu	37	chr1	236341831	236341831	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggttatcgtctctgtgcgAgtggccattaatgacacgct	9	12	11	9	3	1	1	0	1	1	0	3	2	1	1	1	2	1	2	1	2	3	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:236341831A>T	uc001hxq.2	+	3	673	c.582A>T	c.(580-582)CGA>CGT	p.R194R	GPR137B_uc001hxr.1_5'UTR|GPR137B_uc009xge.2_RNA	NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	194	Helical; (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			TCTCTGTGCGAGTGGCCATTA	0.473													27	54					0	0	0	0	T	236341831	T	T	236341831	2	4	296	1	0	0	0	0	0	0	0	1	6684	291	11	5		5	GPR137B	1	236341831	Silent	SNP	A	TCGA-H7-7774-01A-21D-2078-08	29206126	236341831	12908790	13	54753											
RYR2	6262	broad.mit.edu	37	chr1	237969504	237969504	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctataacaactttttttttgCcgctcaccttctcgacattg	8	17	4	12	2	2	0	1	0	1	0	3	1	2	0	2	0	3	1	2	0	3	8			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr1:237969504C>T	uc001hyl.1	+	99	14339	c.14219C>T	c.(14218-14220)GCC>GTC	p.A4740V	RYR2_uc010pyb.1_Missense_Mutation_p.A173V	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4740	Helical; Name=M7; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTTTTTTTGCCGCTCACCTT	0.403													3	29					0	0	0	0	T	237969504	T	T	237969504	3	4	296	1	0	0	0	0	1	0	0	0	13834	739	26	4	14613	4	RYR2	1	237969504	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	1627673	237969504	11281117	14	54754											
LTBP1	4052	broad.mit.edu	37	chr2	33413884	33413884	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgtggctgctaagacacagcTtggccggtgcttccaggaaa	9	8	13	11	2	0	1	0	0	0	1	1	2	1	2	2	4	3	4	2	4	2	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:33413884T>C	uc002ros.2	+	7	1667	c.1667T>C	c.(1666-1668)CTT>CCT	p.L556P	LTBP1_uc002rot.2_Missense_Mutation_p.L230P|LTBP1_uc002rou.2_Missense_Mutation_p.L230P|LTBP1_uc002rov.2_Missense_Mutation_p.L230P|LTBP1_uc010ymz.1_Missense_Mutation_p.L230P|LTBP1_uc010yna.1_Missense_Mutation_p.L230P	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	556					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAGACACAGCTTGGCCGGTGC	0.498													36	80					0	0	0	0	C	33413884	C	C	33413884	3	2	296	1	0	0	0	0	1	0	0	0	9123	1609	56	5	1748	5	LTBP1	2	33413884	Missense_Mutation	SNP	T	TCGA-H7-7774-01A-21D-2078-08		33413884	209785489	15	54755											
GPR75	10936	broad.mit.edu	37	chr2	54080512	54080512	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagtgttgatgtccagcaGagatcttgggactcaccata	11	10	10	10	0	2	2	1	1	1	1	3	4	3	3	2	1	1	2	2	1	1	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:54080512G>A	uc002rxo.3	-	2	1653	c.1382C>T	c.(1381-1383)TCT>TTT	p.S461F	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	461	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ATGTCCAGCAGAGATCTTGGG	0.488													16	134					0	0	0	0	A	54080512	A	A	54080512	3	1	296	1	0	0	0	0	1	0	0	0	6746	942	33	2	244	2	GPR75	2	54080512	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	20666628	54080512	189118861	16	54756											
COX5B	1329	broad.mit.edu	37	chr2	98264531	98264531	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccagcgatgcccccgctgtgGagcccattacaagctggtgc	7	7	12	15	2	0	0	0	0	0	0	0	2	0	1	4	2	6	2	4	2	2	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:98264531G>A	uc002sya.2	+	4	379	c.350G>A	c.(349-351)GGA>GAA	p.G117E		NM_001862	NP_001853	P10606	COX5B_HUMAN	cytochrome c oxidase subunit Vb precursor	117					respiratory electron transport chain|respiratory gaseous exchange	mitochondrial inner membrane	cytochrome-c oxidase activity|metal ion binding				0						CCCCGCTGTGGAGCCCATTAC	0.502													3	30					0	0	0	0	A	98264531	A	A	98264531	3	1	296	1	0	0	0	0	1	0	0	0	3788	1174	41	2	364	2	COX5B	2	98264531	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	44184019	98264531	144934842	17	54757											
GRB14	2888	broad.mit.edu	37	chr2	165365311	165365311	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttttttgcctgccagtgacaCataaatatcactattgccaa	12	14	5	10	0	1	1	1	1	0	0	1	1	1	1	3	0	3	0	3	0	5	7			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:165365311C>T	uc002ucl.2	-	7	1409	c.868G>A	c.(868-870)GTG>ATG	p.V290M	GRB14_uc010zcv.1_Missense_Mutation_p.V203M|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	290	PH.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						GCCAGTGACACATAAATATCA	0.348													16	63					0	0	0	0	T	165365311	T	T	165365311	3	4	296	1	0	0	0	0	1	0	0	0	6796	478	17	4	786	4	GRB14	2	165365311	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	67100780	165365311	77834062	18	54758											
CIR1	9541	broad.mit.edu	37	chr2	175252492	175252492	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttatcatatgatattttctGttctgccatccatacctaga	10	17	4	10	0	3	2	1	1	2	1	4	2	4	2	3	0	2	1	3	0	5	8			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:175252492G>A	uc002uim.2	-	2	181	c.88C>T	c.(88-90)CAG>TAG	p.Q30*	CIR1_uc002uin.2_5'UTR|CIR1_uc002uio.2_5'UTR|CIR1_uc002uip.2_5'UTR	NM_004882	NP_004873	Q86X95	CIR1_HUMAN	CBF1 interacting corepressor	30	Interaction with RBPJ.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			large_intestine(1)	1						GATATTTTCTGTTCTGCCATC	0.254													11	42					0	0	0	0	A	175252492	A	A	175252492	4	1	296	1	0	0	0	0	0	1	0	0	3447	1386	48	4	1300	4	CIR1	2	175252492	Nonsense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	9887181	175252492	67946881	19	54759											
NFE2L2	4780	broad.mit.edu	37	chr2	178098810	178098810	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggagaaattcacctgtctCttcatctagttgtaactgag	10	14	9	8	0	4	2	2	1	2	1	5	3	4	2	1	1	1	2	1	1	3	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:178098810C>G	uc002ulh.3	-	2	790	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63Q|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63Q|NFE2L2_uc002uli.3_Missense_Mutation_p.E63Q|NFE2L2_uc010fra.2_Missense_Mutation_p.E63Q|NFE2L2_uc010frb.2_Missense_Mutation_p.E63Q	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			3	46					0	0	0	0	G	178098810	G	G	178098810	3	3	296	1	0	0	0	0	1	0	0	0	10422	922	32	2	1598	2	NFE2L2	2	178098810	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	2846318	178098810	65100563	20	54760											
NFE2L2	4780	broad.mit.edu	37	chr2	178098957	178098957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacttctcgacttactccaaGatctatatcttgcctccaaa	11	14	3	13	1	3	1	0	0	3	1	6	2	5	1	3	0	3	0	3	0	6	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:178098957G>A	uc002ulh.3	-	2	643	c.88C>T	c.(88-90)CTT>TTT	p.L30F	NFE2L2_uc002ulg.3_Missense_Mutation_p.L14F|NFE2L2_uc010zfa.1_Missense_Mutation_p.L14F|NFE2L2_uc002uli.3_Missense_Mutation_p.L14F|NFE2L2_uc010fra.2_Missense_Mutation_p.L14F|NFE2L2_uc010frb.2_Missense_Mutation_p.L14F	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	30					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			CTTACTCCAAGATCTATATCT	0.368			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			7	25					0	0	0	0	A	178098957	A	A	178098957	3	1	296	1	0	0	0	0	1	0	0	0	10422	942	33	2	1745	2	NFE2L2	2	178098957	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	147	178098957	65100416	21	54761											
TTN	7273	broad.mit.edu	37	chr2	179584490	179584490	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtgttccagtcactacaCactctaatgcaaaaggattt	12	12	7	10	0	2	0	1	0	1	0	3	1	3	1	1	2	2	2	1	2	4	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:179584490C>A	uc010zfg.1	-	79	20221	c.19997G>T	c.(19996-19998)TGT>TTT	p.C6666F	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.C3327F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7593							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTCACTACACACTCTAATGC	0.398													4	54					0.00024832	0.00025496	1	0	A	179584490	A	A	179584490	3	1	296	1	0	0	0	0	1	0	0	0	16803	478	17	4	80924	4	TTN	2	179584490	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	1485533	179584490	63614883	22	54762											
MPP4	58538	broad.mit.edu	37	chr2	202523236	202523236	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	accgtagccaacaaactcctCcttgtctgaaacacaaagaa	16	7	5	13	1	1	2	0	1	1	1	3	2	3	2	4	0	4	1	4	0	6	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:202523236C>T	uc002uyk.3	-	16	1301	c.1093G>A	c.(1093-1095)GAG>AAG	p.E365K	MPP4_uc002uyi.3_5'UTR|MPP4_uc010ftj.2_Missense_Mutation_p.E358K|MPP4_uc010zhq.1_Missense_Mutation_p.E334K|MPP4_uc010zhr.1_Missense_Mutation_p.E341K|MPP4_uc010zhs.1_Missense_Mutation_p.E290K|MPP4_uc002uyj.3_Missense_Mutation_p.E330K|MPP4_uc010zht.1_Missense_Mutation_p.E307K|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Missense_Mutation_p.E321K	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	365						cytoplasm	protein binding				0						ACAAACTCCTCCTTGTCTGAA	0.368													8	15					0	0	0	0	T	202523236	T	T	202523236	3	4	296	1	0	0	0	0	1	0	0	0	9789	864	30	2	848	2	MPP4	2	202523236	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	22938746	202523236	40676137	23	54763											
ACCN4	55515	broad.mit.edu	37	chr2	220397137	220397137	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacagtgtgtctgcctgccGgctgcgctgtgaaaaggagg	7	9	15	10	2	1	1	0	1	1	0	1	2	1	2	2	3	4	2	2	3	3	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:220397137G>A	uc002vma.2	+	4	1351	c.1337G>A	c.(1336-1338)CGG>CAG	p.R446Q	ACCN4_uc010fwi.1_Missense_Mutation_p.R446Q|ACCN4_uc010fwj.1_Missense_Mutation_p.R446Q|ACCN4_uc002vly.1_3'UTR|ACCN4_uc002vlz.2_Missense_Mutation_p.R446Q|ACCN4_uc002vmb.2_Missense_Mutation_p.R100Q	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	446	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		TCTGCCTGCCGGCTGCGCTGT	0.677													15	24					0	0	0	0	A	220397137	A	A	220397137	3	1	296	1	0	0	0	0	1	0	0	0	131	1116	39	1	1351	1	ACCN4	2	220397137	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	17873901	220397137	22802236	24	54764											
RBM44	375316	broad.mit.edu	37	chr2	238726938	238726938	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcattgacagatgcagcaaGttgtacagtcacaattaatc	15	11	7	8	0	2	2	2	1	0	1	3	2	2	2	0	0	3	4	0	0	4	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr2:238726938G>A	uc002vxi.3	+	3	1511	c.1379G>A	c.(1378-1380)AGT>AAT	p.S460N		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	459							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		GATGCAGCAAGTTGTACAGTC	0.398													15	28					0	0	0	0	A	238726938	A	A	238726938	3	1	296	1	0	0	0	0	1	0	0	0	13203	1029	36	4	1385	4	RBM44	2	238726938	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	18329801	238726938	4472435	25	54765											
OXTR	5021	broad.mit.edu	37	chr3	8809643	8809645	+	In_Frame_Del	DEL	GAA	-	-																															gcgatgcttaggtgcttcatGaagaagaagaggcgcgagtg																										TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:8809643_8809645delGAA	uc003brc.2	-	3	851_853	c.229_231delTTC	c.(229-231)TTCdel	p.F77del		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	77	Helical; Name=2; (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GGTGCTTCATGAAGAAGAAGAGG	0.635													---	---	---								-	8809645	-	-	8809643	7	5	296	1	0	1	0	1	0	0	0	0	11392	1281	45	0	946	0	OXTR	3	8809643	In_Frame_Del	DEL	GAA	TCGA-H7-7774-01A-21D-2078-08		8809643	189212787	26	54766											
MTMR14	64419	broad.mit.edu	37	chr3	9691417	9691417	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaggatggcagcgggaccggCggctctaaggtgagattgga	10	6	18	7	3	1	1	0	1	1	1	1	5	1	4	1	7	1	2	1	7	2	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:9691417C>A	uc003brz.2	+	1	274	c.150C>A	c.(148-150)GGC>GGA	p.G50G	MTMR14_uc003bsa.2_Silent_p.G50G|MTMR14_uc003bsb.2_Silent_p.G50G|MTMR14_uc011ath.1_RNA|MTMR14_uc010hcl.2_Silent_p.G50G	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	50						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					GCGGGACCGGCGGCTCTAAGG	0.612													7	13					5.18039e-06	5.46503e-06	1	0	A	9691417	A	A	9691417	2	1	296	1	0	0	0	0	0	0	0	1	9995	755	27	3		3	MTMR14	3	9691417	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	881774	9691417	188331013	27	54767											
PLCL2	23228	broad.mit.edu	37	chr3	17056295	17056295	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccccgctttctggggccCgataacacacccctagtggt	6	10	9	16	2	2	0	0	0	2	0	3	1	2	0	5	3	1	1	5	3	2	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:17056295C>T	uc011awc.1	+	6	2991	c.2886C>T	c.(2884-2886)CCC>CCT	p.P962P	PLCL2_uc011awd.1_Silent_p.P844P	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	970					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						TTCTGGGGCCCGATAACACAC	0.542													43	115					0	0	0	0	T	17056295	T	T	17056295	2	4	296	1	0	0	0	0	0	0	0	1	12095	639	23	1		1	PLCL2	3	17056295	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	7364878	17056295	180966135	28	54768											
TBC1D5	9779	broad.mit.edu	37	chr3	17226630	17226630	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtccatcacctttgcacagTatttgcacatggcatccagg	9	12	8	12	0	1	0	1	0	0	0	3	0	3	0	3	2	2	4	3	2	1	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:17226630T>C	uc003cbf.2	-	19	3488	c.1823A>G	c.(1822-1824)TAC>TGC	p.Y608C	TBC1D5_uc010heu.2_Missense_Mutation_p.Y195C|TBC1D5_uc010hev.2_Missense_Mutation_p.Y630C|TBC1D5_uc003cbe.2_Missense_Mutation_p.Y608C|TBC1D5_uc010hew.1_Missense_Mutation_p.Y582C	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	608						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						CTTTGCACAGTATTTGCACAT	0.383													18	50					0	0	0	0	C	17226630	C	C	17226630	3	2	296	1	0	0	0	0	1	0	0	0	15689	1638	57	5	580	5	TBC1D5	3	17226630	Missense_Mutation	SNP	T	TCGA-H7-7774-01A-21D-2078-08	170335	17226630	180795800	29	54769											
ZCWPW2	152098	broad.mit.edu	37	chr3	28557085	28557085	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttttgaaaatgtttattctGatgatgccttatcaaaggag	12	16	8	5	0	2	3	1	3	1	0	2	4	2	4	1	1	1	1	1	1	5	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:28557085G>A	uc003ceh.2	+	8	925	c.757G>A	c.(757-759)GAT>AAT	p.D253N	ZCWPW2_uc003cei.2_Missense_Mutation_p.D253N|ZCWPW2_uc010hfo.2_Missense_Mutation_p.D58N	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	253							zinc ion binding			ovary(2)	2						TGTTTATTCTGATGATGCCTT	0.308													7	20					0	0	0	0	A	28557085	A	A	28557085	3	1	296	1	0	0	0	0	1	0	0	0	17665	1290	45	2	779	2	ZCWPW2	3	28557085	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	11330455	28557085	169465345	30	54770											
SETD2	29072	broad.mit.edu	37	chr3	47147603	47147603	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tccacaatattctaggacaaAggtgttcctgcaaaccaaaa	16	9	6	10	0	1	0	0	0	1	0	3	1	3	1	3	2	2	2	3	2	7	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:47147603A>T	uc003cqs.2	-	6	4776	c.4723T>A	c.(4723-4725)TTT>ATT	p.F1575I	SETD2_uc003cqv.2_Missense_Mutation_p.F1564I	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1575	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TCTAGGACAAAGGTGTTCCTG	0.363			N|F|S|Mis		clear cell renal carcinoma								10	26					0	0	0	0	T	47147603	T	T	47147603	3	4	296	1	0	0	0	0	1	0	0	0	14196	72	3	5	3035	5	SETD2	3	47147603	Missense_Mutation	SNP	A	TCGA-H7-7774-01A-21D-2078-08	18590518	47147603	150874827	31	54771											
PLXNB1	5364	broad.mit.edu	37	chr3	48460693	48460693	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcctagcagccggatttccCgctccacatggaccggcatc	7	8	10	16	3	0	0	0	0	0	0	3	2	2	2	5	3	3	3	5	3	1	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:48460693C>G	uc003csw.2	-	12	3062	c.2792G>C	c.(2791-2793)CGG>CCG	p.R931P	PLXNB1_uc003csu.2_Missense_Mutation_p.R748P|PLXNB1_uc003csx.2_Missense_Mutation_p.R931P|PLXNB1_uc010hjx.1_RNA|PLXNB1_uc003csy.1_5'Flank	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	931	Extracellular (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCGGATTTCCCGCTCCACATG	0.612													9	12					0	0	0	0	G	48460693	G	G	48460693	3	3	296	1	0	0	0	0	1	0	0	0	12178	652	23	3	3723	3	PLXNB1	3	48460693	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	1313090	48460693	149561737	32	54772											
CADM2	253559	broad.mit.edu	37	chr3	85932554	85932554	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acacctgttctttatttacaAtgcctgtcaaaacttccaag	12	14	4	11	0	2	0	1	0	1	0	3	0	3	0	3	0	3	1	3	0	6	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:85932554A>T	uc003dqj.2	+	3	951	c.325A>T	c.(325-327)ATG>TTG	p.M109L	CADM2_uc003dqk.2_Missense_Mutation_p.M118L|CADM2_uc003dql.2_Missense_Mutation_p.M111L	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	109	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TTTATTTACAATGCCTGTCAA	0.428													13	22					0	0	0	0	T	85932554	T	T	85932554	3	4	296	1	0	0	0	0	1	0	0	0	2579	101	4	5	406	5	CADM2	3	85932554	Missense_Mutation	SNP	A	TCGA-H7-7774-01A-21D-2078-08	37471861	85932554	112089876	33	54773											
EPHA3	2042	broad.mit.edu	37	chr3	89468369	89468369	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	taacaggtgaatttggagagGtgtgcagtggtcgcttaaaa	12	11	14	4	1	0	2	0	1	0	1	1	3	0	2	0	4	2	2	0	4	4	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:89468369G>T	uc003dqy.2	+	11	2128	c.1903G>T	c.(1903-1905)GTG>TTG	p.V635L	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	635	Cytoplasmic (Potential).|Protein kinase.|ATP (By similarity).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATTTGGAGAGGTGTGCAGTGG	0.363										TSP Lung(6;0.00050)			25	41					7.92952e-12	8.80039e-12	1	0	T	89468369	T	T	89468369	3	4	296	1	0	0	0	0	1	0	0	0	5192	1261	44	4	1971	4	EPHA3	3	89468369	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	3535815	89468369	108554061	34	54774											
FAM55C	91775	broad.mit.edu	37	chr3	101520161	101520161	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccaggtgacaggaattagccGaaatccctactgtggctatg	11	9	11	10	1	0	1	0	1	0	0	1	3	1	2	3	3	2	1	3	3	5	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:101520161G>A	uc003dvn.2	+	5	813	c.176G>A	c.(175-177)CGA>CAA	p.R59Q	FAM55C_uc010hpn.2_Missense_Mutation_p.R59Q	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	59						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						GGAATTAGCCGAAATCCCTAC	0.532													6	127					0	0	0	0	A	101520161	A	A	101520161	3	1	296	1	0	0	0	0	1	0	0	0	5618	1058	37	1	182	1	FAM55C	3	101520161	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	12051792	101520161	96502269	35	54775											
ADCY5	111	broad.mit.edu	37	chr3	123046600	123046600	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agtgtagccttggtgatgtgGatgcgtctacaggggggcag	7	10	18	6	1	1	1	0	1	1	0	1	2	1	2	1	5	3	2	1	5	2	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:123046600G>C	uc003egh.1	-	7	1812	c.1812C>G	c.(1810-1812)ATC>ATG	p.I604M	ADCY5_uc003egg.1_Missense_Mutation_p.I237M|ADCY5_uc003egi.1_Missense_Mutation_p.I163M	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	604	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TGGTGATGTGGATGCGTCTAC	0.552													3	25					0	0	0	0	C	123046600	C	C	123046600	3	2	296	1	0	0	0	0	1	0	0	0	297	1164	41	2	2033	2	ADCY5	3	123046600	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	21526439	123046600	74975830	36	54776											
GHSR	2693	broad.mit.edu	37	chr3	172165820	172165820	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgatggtgagcaccgtggcGtaggtgcagctctcactgac	7	9	15	10	2	1	3	1	3	1	0	2	3	1	3	1	3	3	4	1	3	1	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:172165820G>A	uc003fib.1	-	1	384	c.384C>T	c.(382-384)TAC>TAT	p.Y128Y	GHSR_uc011bpv.1_Silent_p.Y128Y	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	128	Helical; Name=3; (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GCACCGTGGCGTAGGTGCAGC	0.632													8	19					0	0	0	0	A	172165820	A	A	172165820	2	1	296	1	0	0	0	0	0	0	0	1	6412	1140	40	1		1	GHSR	3	172165820	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	49119220	172165820	25856610	37	54777											
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	17	7	10	7	0	1	2	1	2	0	0	1	4	1	3	0	3	3	2	0	3	5	0	rs121913279		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			17	61					0	0	0	0	G	178952085	G	G	178952085	3	3	296	1	0	0	0	0	1	0	0	0	11968	217	8	5	3218	5	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-H7-7774-01A-21D-2078-08	6786265	178952085	19070345	38	54778											
RGS12	6002	broad.mit.edu	37	chr4	3318626	3318626	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccattgagcttccttccacGagctccaacctggagtccga	8	10	8	15	2	0	1	0	1	0	0	5	4	5	2	6	1	3	2	6	1	1	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:3318626G>A	uc003ggw.2	+	2	1633	c.729G>A	c.(727-729)ACG>ACA	p.T243T	RGS12_uc003ggu.2_Silent_p.T243T|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Silent_p.T243T|RGS12_uc003ggx.1_Silent_p.T243T	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	243	PID.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTCCTTCCACGAGCTCCAACC	0.532													13	46					0	0	0	0	A	3318626	A	A	3318626	2	1	296	1	0	0	0	0	0	0	0	1	13360	1045	37	1		1	RGS12	4	3318626	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08		3318626	187835650	39	54779											
CLOCK	9575	broad.mit.edu	37	chr4	56315585	56315585	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gactactaaatgatgaccttCtttgcaccatcttctcatga	11	14	5	11	0	3	3	1	3	3	0	4	4	3	3	2	0	2	1	2	0	3	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:56315585C>G	uc003haz.1	-	18	2353	c.1427G>C	c.(1426-1428)AGA>ACA	p.R476T	CLOCK_uc003hba.1_Missense_Mutation_p.R476T|CLOCK_uc010igu.1_RNA	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	476					circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			TGATGACCTTCTTTGCACCAT	0.398													23	48					0	0	0	0	G	56315585	G	G	56315585	3	3	296	1	0	0	0	0	1	0	0	0	3564	913	32	2	1141	2	CLOCK	4	56315585	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	52996959	56315585	134838691	40	54780											
FAT4	79633	broad.mit.edu	37	chr4	126412412	126412412	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagtgcagaccatgggaGgtcttcttcagaggaggact	9	9	14	9	0	3	2	1	0	2	2	3	5	3	5	1	4	2	2	1	4	0	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:126412412G>T	uc003ifj.3	+	17	14435	c.14435G>T	c.(14434-14436)AGG>ATG	p.R4812M	FAT4_uc011cgp.1_Missense_Mutation_p.R3053M|FAT4_uc003ifi.1_Missense_Mutation_p.R2289M	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4812	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GACCATGGGAGGTCTTCTTCA	0.512													21	45					2.39187e-15	2.68561e-15	1	0	T	126412412	T	T	126412412	3	4	296	1	0	0	0	0	1	0	0	0	5724	1000	35	4	14501	4	FAT4	4	126412412	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	70096827	126412412	64741864	41	54781											
TMEM184C	55751	broad.mit.edu	37	chr4	148554974	148554974	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctcatcattacacattctCatataaaccatatgtccaag	14	13	3	11	0	3	0	3	0	1	0	5	0	4	0	2	0	3	1	2	0	6	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:148554974C>T	uc003ila.3	+	9	1507	c.938C>T	c.(937-939)TCA>TTA	p.S313L		NM_018241	NP_060711	Q9NVA4	T184C_HUMAN	transmembrane protein 184C	313						integral to membrane					0						TACACATTCTCATATAAACCA	0.368													4	83					0	0	0	0	T	148554974	T	T	148554974	3	4	296	1	0	0	0	0	1	0	0	0	16172	838	29	2	972	2	TMEM184C	4	148554974	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	22142562	148554974	42599302	42	54782											
TIGD4	201798	broad.mit.edu	37	chr4	153691769	153691770	+	Frame_Shift_Ins	INS	-	A	A																															aaacgatccagccaaccattINSactgcacttaaaatcattat																										TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:153691769_153691770insA	uc003imy.2	-	2	1169_1170	c.387_388insT	c.(385-390)AGTAATfs	p.S129fs		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	129_130	HTH CENPB-type.|H-T-H motif (By similarity).				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					AGCCAACCATTACTGCACTTAA	0.416													---	---	---								A	153691770	A	A	153691769	7	5	296	1	0	1	1	0	0	0	0	0	15964	1754	61	0	1154	0	TIGD4	4	153691769	Frame_Shift_Ins	INS	-	TCGA-H7-7774-01A-21D-2078-08	5136795	153691769	37462507	43	54783											
FAT1	2195	broad.mit.edu	37	chr4	187525008	187525008	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatgacgccacctgagtattCttctccagaagaggtgatga	12	10	10	9	1	2	6	0	4	2	2	3	6	2	6	3	1	0	1	3	1	3	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:187525008C>A	uc003izf.2	-	19	10860	c.10672G>T	c.(10672-10674)GAA>TAA	p.E3558*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3558	Extracellular (Potential).|Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CCTGAGTATTCTTCTCCAGAA	0.473										HNSCC(5;0.00058)			7	28					8.12818e-05	8.43574e-05	1	0	A	187525008	A	A	187525008	4	1	296	1	0	0	0	0	0	1	0	0	5721	922	32	2	3130	2	FAT1	4	187525008	Nonsense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	33833239	187525008	3629268	44	54784											
FAT1	2195	broad.mit.edu	37	chr4	187539863	187539863	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	aggtgatgtcggcattggagCcctcatcggcatcacttgca	8	10	12	11	2	2	1	2	1	0	0	4	2	2	2	1	4	2	3	1	4	0	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr4:187539863C>T	uc003izf.2	-	10	8065	c.7877G>A	c.(7876-7878)GGC>GAC	p.G2626D		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2626	Extracellular (Potential).|Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGCATTGGAGCCCTCATCGGC	0.448										HNSCC(5;0.00058)			9	27					0	0	0	0	T	187539863	T	T	187539863	3	4	296	1	0	0	0	0	1	0	0	0	5721	739	26	4	5961	4	FAT1	4	187539863	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	14855	187539863	3614413	45	54785											
SPEF2	79925	broad.mit.edu	37	chr5	35659168	35659168	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aaccggctgatgcggcagtcCcagcaggagcgcaggattgc	9	5	15	12	3	0	1	0	1	0	0	1	3	1	3	2	4	5	4	2	4	1	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:35659168C>T	uc003jjo.2	+	8	1137	c.1026C>T	c.(1024-1026)TCC>TCT	p.S342S	SPEF2_uc003jjn.1_Silent_p.S342S|SPEF2_uc003jjq.3_Silent_p.S342S	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	342	Potential.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGCGGCAGTCCCAGCAGGAGC	0.468													11	18					0	0	0	0	T	35659168	T	T	35659168	2	4	296	1	0	0	0	0	0	0	0	1	15101	610	22	4		4	SPEF2	5	35659168	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08		35659168	145256092	46	54786											
JMY	133746	broad.mit.edu	37	chr5	78611869	78611869	+	Frame_Shift_Del	DEL	T	-	-																															gcctccttgaagcgtggtagTtttcatctgaaaaaggttga																										TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:78611869delT	uc003kfx.3	+	10	3226	c.2706delT	c.(2704-2706)AGTfs	p.S902fs		NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	902					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		AGCGTGGTAGTTTTCATCTGA	0.393													---	---	---								-	78611869	-	-	78611869	7	5	296	1	0	1	0	1	0	0	0	0	7996	1722	60	0	2744	0	JMY	5	78611869	Frame_Shift_Del	DEL	T	TCGA-H7-7774-01A-21D-2078-08	42952701	78611869	102303391	47	54787											
MEF2C	4208	broad.mit.edu	37	chr5	88027717	88027717	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cggggattgccatacccgttCcctgttaacaaaaaacaata	14	9	7	11	2	0	0	0	0	0	0	1	1	1	1	3	2	4	2	3	2	7	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:88027717C>T	uc003kjj.2	-	7	1312	c.639G>A	c.(637-639)GGG>GGA	p.G213G	MEF2C_uc003kji.2_Silent_p.G213G|MEF2C_uc003kjk.2_Silent_p.G213G|MEF2C_uc003kjm.2_Silent_p.G211G|MEF2C_uc003kjl.2_Silent_p.G231G	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	213					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		CATACCCGTTCCCTGTTAACA	0.388										HNSCC(66;0.2)			6	11					0	0	0	0	T	88027717	T	T	88027717	2	4	296	1	0	0	0	0	0	0	0	1	9510	869	30	2		2	MEF2C	5	88027717	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	9415848	88027717	92887543	48	54788											
PCDHA9	9752	broad.mit.edu	37	chr5	140230437	140230437	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgctggatctacagagcgaaCgggagaaccctctgcttcct	9	9	11	12	2	2	2	0	0	2	2	3	5	3	3	2	2	6	2	2	2	3	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:140230437C>T	uc003lhu.2	+	1	3081	c.2357C>T	c.(2356-2358)ACG>ATG	p.T786M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.T786M	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	786	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGAGCGAACGGGAGAACCC	0.463													17	53					0	0	0	0	T	140230437	T	T	140230437	3	4	296	1	0	0	0	0	1	0	0	0	11585	536	19	1	2359	1	PCDHA9	5	140230437	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	52202720	140230437	40684823	49	54789											
PCDHA12	56137	broad.mit.edu	37	chr5	140257232	140257232	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgcgctgcgttgctcagcGccgcccaccgtgagccggtg	4	7	14	16	6	1	1	1	1	0	0	1	1	1	1	4	1	5	3	4	1	0	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:140257232G>A	uc003lic.2	+	1	2302	c.2175G>A	c.(2173-2175)GCG>GCA	p.A725A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.A725A	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	725	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTGCTCAGCGCCGCCCACCG	0.647													4	26					0	0	0	0	A	140257232	A	A	140257232	2	1	296	1	0	0	0	0	0	0	0	1	11576	1074	38	1		1	PCDHA12	5	140257232	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	26795	140257232	40658028	50	54790											
KCNIP1	30820	broad.mit.edu	37	chr5	170148874	170148874	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cattacctcttcaatgccttCgacaccactcagacaggctc	10	10	5	16	1	3	1	2	0	1	1	5	2	3	1	3	1	2	1	3	1	2	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr5:170148874C>T	uc003mas.2	+	5	856	c.327C>T	c.(325-327)TTC>TTT	p.F109F	KCNIP1_uc003map.2_Silent_p.F107F|KCNIP1_uc003mat.2_Silent_p.F98F|KCNIP1_uc010jjp.2_Silent_p.F70F|KCNIP1_uc010jjq.2_Silent_p.F123F	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	109	EF-hand 2.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCAATGCCTTCGACACCACTC	0.547													51	96					0	0	0	0	T	170148874	T	T	170148874	2	4	296	1	0	0	0	0	0	0	0	1	8078	883	31	1		1	KCNIP1	5	170148874	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	29891642	170148874	10766386	51	54791											
BMP6	654	broad.mit.edu	37	chr6	7727808	7727808	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gaccagcgcgcaggacagcgCcttcctcaacgacgcggaca	10	3	12	16	6	1	0	1	0	0	0	2	4	2	2	3	2	3	1	3	2	1	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:7727808C>T	uc003mxu.3	+	1	798	c.620C>T	c.(619-621)GCC>GTC	p.A207V		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	207					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					CAGGACAGCGCCTTCCTCAAC	0.647													5	14					0	0	0	0	T	7727808	T	T	7727808	3	4	296	1	0	0	0	0	1	0	0	0	1467	739	26	4	622	4	BMP6	6	7727808	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08		7727808	163387259	52	54792											
C6orf62	81688	broad.mit.edu	37	chr6	24709057	24709059	+	In_Frame_Del	DEL	ACA	-	-																															ctgactggttaggattgttgAcaacgattccagtcttgtcc																										TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:24709057_24709059delACA	uc003nel.2	-	4	1017_1019	c.510_512delTGT	c.(508-513)GTTGTC>GTC	p.170_171VV>V		NM_030939	NP_112201	Q9GZU0	CF062_HUMAN	hypothetical protein LOC81688	170_171						intracellular					0						AGGATTGTTGACAACGATTCCAG	0.384													---	---	---								-	24709059	-	-	24709057	7	5	296	1	0	1	0	1	0	0	0	0	2378	275	10	0	185	0	C6orf62	6	24709057	In_Frame_Del	DEL	ACA	TCGA-H7-7774-01A-21D-2078-08	16981249	24709057	146406010	53	54793											
HIST1H1C	3006	broad.mit.edu	37	chr6	26056394	26056394	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccagagtgcccttgctcAccaggctcttgagaccaagt	9	8	10	14	0	2	2	1	1	1	2	2	3	2	2	4	1	2	3	4	1	1	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:26056394A>C	uc003nfw.2	-	1	306	c.263T>G	c.(262-264)GTG>GGG	p.V88G		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	88	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GCCCTTGCTCACCAGGCTCTT	0.532													14	94					0	0	0	0	C	26056394	C	C	26056394	3	2	296	1	0	0	0	0	1	0	0	0	7163	159	6	5	382	5	HIST1H1C	6	26056394	Missense_Mutation	SNP	A	TCGA-H7-7774-01A-21D-2078-08	1347337	26056394	145058673	54	54794											
FKBPL	63943	broad.mit.edu	37	chr6	32097032	32097032	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccagagtgcccaggcagctGaagctctgcttcctcacctt	7	10	9	15	0	2	2	1	1	1	1	4	2	4	2	4	1	4	4	4	1	1	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:32097032G>A	uc003nzr.2	-	2	796	c.526C>T	c.(526-528)CAG>TAG	p.Q176*	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	176					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						CCAGGCAGCTGAAGCTCTGCT	0.572													10	149					0	0	0	0	A	32097032	A	A	32097032	4	1	296	1	0	0	0	0	0	1	0	0	5948	1299	45	2	527	2	FKBPL	6	32097032	Nonsense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	6040638	32097032	139018035	55	54795											
HACE1	57531	broad.mit.edu	37	chr6	105233004	105233004	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ctggtttagattcccttgtgCcagtggacagattttcatag	8	15	10	8	0	1	2	1	0	0	2	2	3	2	3	2	2	1	1	2	2	2	7			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:105233004C>T	uc003pqu.1	-	12	1542	c.1265G>A	c.(1264-1266)GGC>GAC	p.G422D	HACE1_uc010kcy.1_5'UTR|HACE1_uc010kcz.1_Missense_Mutation_p.G422D|HACE1_uc010kcx.1_5'UTR|HACE1_uc003pqt.1_Missense_Mutation_p.G75D	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	422					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		TTCCCTTGTGCCAGTGGACAG	0.458													3	46					0	0	0	0	T	105233004	T	T	105233004	3	4	296	1	0	0	0	0	1	0	0	0	6979	739	26	4	1516	4	HACE1	6	105233004	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	73135972	105233004	65882063	56	54796											
HS3ST5	222537	broad.mit.edu	37	chr6	114378489	114378489	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaaaggatgaaagaatttgcGcaatttagtaatgacagagg	18	9	11	3	1	0	4	0	2	0	2	0	5	0	5	0	2	1	2	0	2	7	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:114378489G>A	uc003pwg.3	-	2	1005	c.973C>T	c.(973-975)CGC>TGC	p.R325C	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.R325C	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	325	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		AAGAATTTGCGCAATTTAGTA	0.408													23	44					0	0	0	0	A	114378489	A	A	114378489	3	1	296	1	0	0	0	0	1	0	0	0	7407	1087	38	1	71	1	HS3ST5	6	114378489	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	9145485	114378489	56736578	57	54797											
LAMA2	3908	broad.mit.edu	37	chr6	129649434	129649434	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttctttcaggcatgcttgccGggattttatcgactgcgttc	5	16	10	10	3	2	0	1	0	1	0	4	2	2	1	1	2	3	3	1	2	1	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:129649434G>A	uc003qbn.2	+	29	4293	c.4188G>A	c.(4186-4188)CCG>CCA	p.P1396P	LAMA2_uc003qbo.2_Silent_p.P1396P	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1396	Laminin EGF-like 14; second part.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CATGCTTGCCGGGATTTTATC	0.507													21	73					0	0	0	0	A	129649434	A	A	129649434	2	1	296	1	0	0	0	0	0	0	0	1	8646	1103	39	1		1	LAMA2	6	129649434	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	15270945	129649434	41465633	58	54798											
TCF21	6943	broad.mit.edu	37	chr6	134210907	134210907	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggacacgctcaggctggcGtccagctacatcgcccactt	7	8	10	16	3	1	0	1	0	0	0	3	1	2	1	2	3	2	3	2	3	1	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:134210907G>A	uc003qei.3	+	1	648	c.372G>A	c.(370-372)GCG>GCA	p.A124A	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Silent_p.A124A	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	124	Helix-loop-helix motif.				branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		TCAGGCTGGCGTCCAGCTACA	0.617													32	94					0	0	0	0	A	134210907	A	A	134210907	2	1	296	1	0	0	0	0	0	0	0	1	15757	1132	40	1		1	TCF21	6	134210907	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	4561473	134210907	36904160	59	54799											
AIG1	51390	broad.mit.edu	37	chr6	143605338	143605338	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cggacttaccgccatatgtaCcttctctgttggctatatat	8	15	7	11	2	1	0	0	0	1	0	2	1	1	1	3	2	2	3	3	2	6	8			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr6:143605338C>T	uc003qjh.2	+	4	531	c.491C>T	c.(490-492)ACC>ATC	p.T164I	AIG1_uc003qjf.2_Missense_Mutation_p.T154I|AIG1_uc003qji.2_Missense_Mutation_p.T102I	NM_016108	NP_057192	Q9NVV5	AIG1_HUMAN	androgen-induced 1	164						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(155;2.34e-05)|GBM - Glioblastoma multiforme(68;0.0246)		GCCATATGTACCTTCTCTGTT	0.433													4	31					0	0	0	0	T	143605338	T	T	143605338	3	4	296	1	0	0	0	0	1	0	0	0	429	507	18	4	505	4	AIG1	6	143605338	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	9394431	143605338	27509729	60	54800											
SUN1	23353	broad.mit.edu	37	chr7	883126	883126	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcggcccccgggcccgtgtcGagagtttattctagggacag	6	8	15	12	4	1	1	0	0	1	1	2	3	1	2	3	3	0	1	3	3	2	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:883126G>A	uc011jvp.1	+	6	706	c.627G>A	c.(625-627)TCG>TCA	p.S209S	SUN1_uc010ksa.1_Silent_p.S230S|SUN1_uc003sje.1_Silent_p.S209S|SUN1_uc003sjf.2_Silent_p.S159S|SUN1_uc011jvq.1_Intron|SUN1_uc003sjg.2_Silent_p.S20S	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	209	SYNE2-binding.|Nuclear.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GGCCCGTGTCGAGAGTTTATT	0.522													47	144					0	0	0	0	A	883126	A	A	883126	2	1	296	1	0	0	0	0	0	0	0	1	15457	1045	37	1		1	SUN1	7	883126	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08		883126	158255537	61	54801											
RAC1	5879	broad.mit.edu	37	chr7	6426860	6426860	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tagagctgtaggtaaaacttGcctactgatcagttacacaa	14	11	8	8	0	1	2	1	1	0	1	1	2	1	2	1	1	5	4	1	1	7	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:6426860G>A	uc003spx.2	+	2	294	c.53G>A	c.(52-54)TGC>TAC	p.C18Y	RAC1_uc003spw.2_Missense_Mutation_p.C18Y	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	18					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	GGTAAAACTTGCCTACTGATC	0.338													17	41					0	0	0	0	A	6426860	A	A	6426860	3	1	296	1	0	0	0	0	1	0	0	0	13039	1319	46	4	59	4	RAC1	7	6426860	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	5543734	6426860	152711803	62	54802											
DFNA5	1687	broad.mit.edu	37	chr7	24756873	24756873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccataggaggtggcactcacCgaactggccgtccagtttca	9	8	11	13	2	2	0	2	0	0	0	3	2	3	1	4	4	1	2	4	4	2	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:24756873C>T	uc010kus.1	-	5	785	c.697G>A	c.(697-699)GAG>AAG	p.E233K	DFNA5_uc003swz.2_Missense_Mutation_p.E69K|DFNA5_uc003sxa.1_Missense_Mutation_p.E233K|DFNA5_uc010kut.1_Missense_Mutation_p.E69K|DFNA5_uc003sxb.2_Missense_Mutation_p.G233S	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	233					sensory perception of sound					ovary(1)	1						TGGCACTCACCGAACTGGCCG	0.562													10	35					0	0	0	0	T	24756873	T	T	24756873	3	4	296	1	0	0	0	0	1	0	0	0	4476	666	23	1	817	1	DFNA5	7	24756873	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	18330013	24756873	134381790	63	54803											
PKD1L1	168507	broad.mit.edu	37	chr7	47944031	47944031	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacggtgccatccccaaaGtcccacaggtaggcaacatc	11	6	9	15	1	0	1	0	1	0	0	3	1	2	1	4	3	2	2	4	3	3	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:47944031G>T	uc003tny.1	-	12	1875	c.1875C>A	c.(1873-1875)GAC>GAA	p.D625E		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	625	Extracellular (Potential).|PKD 2.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CATCCCCAAAGTCCCACAGGT	0.602													13	25					2.27111e-07	2.40913e-07	1	0	T	47944031	T	T	47944031	3	4	296	1	0	0	0	0	1	0	0	0	12019	1020	36	4	6858	4	PKD1L1	7	47944031	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	23187158	47944031	111194632	64	54804											
ZNF479	90827	broad.mit.edu	37	chr7	57188354	57188354	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgagttctcttatgtctagtAaggtttgcagaccagctaaa	11	14	9	7	0	2	2	0	1	2	1	3	2	2	2	1	1	2	5	1	1	5	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:57188354A>G	uc010kzo.2	-	5	1039	c.768T>C	c.(766-768)CTT>CTC	p.L256L		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	256	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TATGTCTAGTAAGGTTTGCAG	0.428													6	32					0	0	0	0	G	57188354	G	G	57188354	2	3	296	1	0	0	0	0	0	0	0	1	18000	349	13	5		5	ZNF479	7	57188354	Silent	SNP	A	TCGA-H7-7774-01A-21D-2078-08	9244323	57188354	101950309	65	54805											
HIP1	3092	broad.mit.edu	37	chr7	75192259	75192259	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgctgagaggcatccatgtCcatgaggtcatccttctcta	8	12	9	12	0	2	2	1	2	1	1	6	3	5	2	3	2	1	2	3	2	1	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:75192259C>T	uc003uds.1	-	11	1041	c.1000G>A	c.(1000-1002)GAC>AAC	p.D334N	HIP1_uc011kfz.1_Missense_Mutation_p.D211N	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	334					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						GCATCCATGTCCATGAGGTCA	0.592			T	PDGFRB	CMML								4	27					0	0	0	0	T	75192259	T	T	75192259	3	4	296	1	0	0	0	0	1	0	0	0	7153	855	30	2	2197	2	HIP1	7	75192259	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	18003905	75192259	83946404	66	54806											
PLXNA4	91584	broad.mit.edu	37	chr7	131849918	131849918	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaacttgtagaggaggaaaGtaaaccaattggtcagcatc	15	8	12	6	0	1	1	1	0	0	1	2	4	1	4	1	4	3	3	1	4	6	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:131849918G>A	uc003vra.3	-	23	4557	c.4328C>T	c.(4327-4329)ACT>ATT	p.T1443I		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1443	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GAGGAGGAAAGTAAACCAATT	0.517													19	47					0	0	0	0	A	131849918	A	A	131849918	3	1	296	1	0	0	0	0	1	0	0	0	12177	1029	36	4	1396	4	PLXNA4	7	131849918	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	56657659	131849918	27288745	67	54807											
GIMAP2	26157	broad.mit.edu	37	chr7	150389491	150389491	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	actggcaaaagtgctgcaggGaacagcatcctcaggaagca	14	5	12	10	0	1	0	1	0	0	0	2	2	2	2	1	3	5	5	1	3	4	0			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:150389491G>A	uc003who.2	+	3	205	c.117G>A	c.(115-117)GGG>GGA	p.G39G	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	39						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGCTGCAGGGAACAGCATCC	0.512													7	23					0	0	0	0	A	150389491	A	A	150389491	2	1	296	1	0	0	0	0	0	0	0	1	6417	1161	41	2		2	GIMAP2	7	150389491	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	18539573	150389491	8749172	68	54808											
MLL3	58508	broad.mit.edu	37	chr7	151859299	151859300	+	Frame_Shift_Ins	INS	-	AAGAT	AAGAT																															aggtttttgattcaaaagagINSaagatgactttttatttttc																										TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr7:151859299_151859300insAAGAT	uc003wla.2	-	43	11581_11582	c.11362_11363insATCTT	c.(11362-11364)TCTfs	p.S3788fs	MLL3_uc003wkz.2_Frame_Shift_Ins_p.S2849fs|MLL3_uc003wky.2_Frame_Shift_Ins_p.S1297fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3788					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATTCAAAAGAGAAGATGACTTT	0.436			N		medulloblastoma								---	---	---								AAGAT	151859300	AAGAT	AAGAT	151859299	7	5	296	1	0	1	1	0	0	0	0	0	9675	942	33	0	3440	0	MLL3	7	151859299	Frame_Shift_Ins	INS	-	TCGA-H7-7774-01A-21D-2078-08	1469808	151859299	7279364	69	54809											
DLGAP2	9228	broad.mit.edu	37	chr8	1626408	1626408	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttaaacgttctaacagcGtcacggccgccgtccaagct	9	10	9	13	5	2	0	1	0	1	0	3	0	3	0	3	1	4	3	3	1	4	4	rs34274599		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:1626408G>A	uc003wpl.2	+	9	2174	c.2077G>A	c.(2077-2079)GTC>ATC	p.V693I	DLGAP2_uc003wpm.2_Missense_Mutation_p.V679I	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	772					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TTCTAACAGCGTCACGGCCGC	0.557													18	36					0	0	0	0	A	1626408	A	A	1626408	3	1	296	1	0	0	0	0	1	0	0	0	4582	1145	40	1	2107	1	DLGAP2	8	1626408	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08		1626408	144737614	70	54810											
CHD7	55636	broad.mit.edu	37	chr8	61765577	61765577	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggagtgtggacggcatgaccGagacttgctggttggtgctg	6	10	18	7	2	0	2	0	1	0	1	0	5	0	4	1	5	2	4	1	5	0	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:61765577G>A	uc003xue.2	+	31	6770	c.6293G>A	c.(6292-6294)CGA>CAA	p.R2098Q		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2098					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CGGCATGACCGAGACTTGCTG	0.542													13	26					0	0	0	0	A	61765577	A	A	61765577	3	1	296	1	0	0	0	0	1	0	0	0	3345	1058	37	1	6411	1	CHD7	8	61765577	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	60139169	61765577	84598445	71	54811											
KCNB2	9312	broad.mit.edu	37	chr8	73480224	73480224	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gactataatctgaacgagaaCgagtatttctttgatcggca	13	12	9	7	3	2	3	0	2	2	1	3	6	2	3	0	1	2	2	0	1	5	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:73480224C>T	uc003xzb.2	+	2	843	c.255C>T	c.(253-255)AAC>AAT	p.N85N		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	85	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TGAACGAGAACGAGTATTTCT	0.512													17	47					0	0	0	0	T	73480224	T	T	73480224	2	4	296	1	0	0	0	0	0	0	0	1	8052	535	19	1		1	KCNB2	8	73480224	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	11714647	73480224	72883798	72	54812											
RAD54B	25788	broad.mit.edu	37	chr8	95419835	95419835	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccaagctgaaaacacctgcCactgctgaagtcatctggag	12	8	9	12	0	2	2	1	2	1	0	3	3	3	3	3	1	4	2	3	1	4	0			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:95419835C>T	uc003ygk.2	-	5	711	c.613G>A	c.(613-615)GGC>AGC	p.G205S	RAD54B_uc010may.1_Missense_Mutation_p.G12S|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			AAACACCTGCCACTGCTGAAG	0.418								Direct_reversal_of_damage|Homologous_recombination					5	44					0	0	0	0	T	95419835	T	T	95419835	3	4	296	1	0	0	0	0	1	0	0	0	13057	594	21	4	2163	4	RAD54B	8	95419835	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	21939611	95419835	50944187	73	54813											
PGCP	10404	broad.mit.edu	37	chr8	97892096	97892096	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcctgtattacggtggaaGatgcagaaatgatgtcaaga	14	9	12	6	1	1	4	1	1	0	3	1	5	1	5	1	2	3	2	1	2	5	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:97892096G>A	uc003yhw.2	+	4	878	c.712G>A	c.(712-714)GAT>AAT	p.D238N	PGCP_uc010mbe.2_Missense_Mutation_p.D238N	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	238					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					TACGGTGGAAGATGCAGAAAT	0.463													5	134					0	0	0	0	A	97892096	A	A	97892096	3	1	296	1	0	0	0	0	1	0	0	0	11841	942	33	2	722	2	PGCP	8	97892096	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	2472261	97892096	48471926	74	54814											
PKHD1L1	93035	broad.mit.edu	37	chr8	110412468	110412468	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacacatttgttgcacgcttTagtggatttttggtggctcc	6	16	11	8	1	0	0	0	0	0	0	1	2	1	1	1	3	1	4	1	3	1	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:110412468T>C	uc003yne.2	+	13	1280	c.1176T>C	c.(1174-1176)TTT>TTC	p.F392F		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	392	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTGCACGCTTTAGTGGATTTT	0.418										HNSCC(38;0.096)			23	228					0	0	0	0	C	110412468	C	C	110412468	2	2	296	1	0	0	0	0	0	0	0	1	12027	1751	61	5		5	PKHD1L1	8	110412468	Silent	SNP	T	TCGA-H7-7774-01A-21D-2078-08	12520372	110412468	35951554	75	54815											
PKHD1L1	93035	broad.mit.edu	37	chr8	110535536	110535536	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gactccaataataaccaagtCaatggccttagtggaaatac	16	9	7	9	0	1	0	1	0	0	0	2	2	2	1	3	2	2	0	3	2	8	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:110535536C>T	uc003yne.2	+	76	12509	c.12405C>T	c.(12403-12405)GTC>GTT	p.V4135V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	4135	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATAACCAAGTCAATGGCCTTA	0.398										HNSCC(38;0.096)			18	48					0	0	0	0	T	110535536	T	T	110535536	2	4	296	1	0	0	0	0	0	0	0	1	12027	813	29	2		2	PKHD1L1	8	110535536	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	123068	110535536	35828486	76	54816											
CSMD3	114788	broad.mit.edu	37	chr8	113353856	113353856	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agtttctgaggatccacttcGtacttccaaataatcatgta	12	14	6	9	1	2	1	1	1	1	0	5	2	4	2	2	1	1	3	2	1	4	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:113353856G>A	uc003ynu.2	-	42	6661	c.6502C>T	c.(6502-6504)CGA>TGA	p.R2168*	CSMD3_uc003yns.2_Nonsense_Mutation_p.R1370*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.R2128*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.R2064*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2168	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GATCCACTTCGTACTTCCAAA	0.368										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	18					0	0	0	0	A	113353856	A	A	113353856	4	1	296	1	0	0	0	0	0	1	0	0	3963	1153	40	1	4741	1	CSMD3	8	113353856	Nonsense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	2818320	113353856	33010166	77	54817											
EIF3H	8667	broad.mit.edu	37	chr8	117658786	117658786	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gacaggtcctcctcagggagCgggggttctcctcggctctg	4	9	15	13	2	3	0	1	0	2	0	7	2	5	1	3	5	1	2	3	5	0	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:117658786C>A	uc003yoa.2	-	7	911	c.885G>T	c.(883-885)CCG>CCT	p.P295P	EIF3H_uc003yob.2_Silent_p.P309P	NM_003756	NP_003747	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3,	295					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					CCTCAGGGAGCGGGGGTTCTC	0.527													44	131					2.47872e-24	2.81607e-24	1	0	A	117658786	A	A	117658786	2	1	296	1	0	0	0	0	0	0	0	1	5042	755	27	3		3	EIF3H	8	117658786	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	4304930	117658786	28705236	78	54818											
PLEC	5339	broad.mit.edu	37	chr8	144991068	144991068	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctccagcagccgctgcccCgtgatgttatccaccaggtt	6	9	10	16	2	0	1	0	1	0	0	2	1	2	1	7	1	3	4	7	1	1	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr8:144991068C>T	uc003zaf.1	-	32	13502	c.13332G>A	c.(13330-13332)ACG>ACA	p.T4444T	PLEC_uc003zab.1_Silent_p.T4307T|PLEC_uc003zac.1_Silent_p.T4311T|PLEC_uc003zad.2_Silent_p.T4307T|PLEC_uc003zae.1_Silent_p.T4275T|PLEC_uc003zag.1_Silent_p.T4285T|PLEC_uc003zah.2_Silent_p.T4293T|PLEC_uc003zaj.2_Silent_p.T4334T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4444	Globular 2.|Plectin 29.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCGCTGCCCCGTGATGTTAT	0.677													3	47					0	0	0	0	T	144991068	T	T	144991068	2	4	296	1	0	0	0	0	0	0	0	1	12107	639	23	1		1	PLEC	8	144991068	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	27332282	144991068	1372954	79	54819											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18574122	18574122	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttttatgaatggcttcctgTgtctaatgaccctgacaacc	9	14	8	10	0	1	3	0	3	1	0	2	3	2	3	3	1	1	2	3	1	4	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:18574122T>C	uc003zne.3	+	4	459	c.332T>C	c.(331-333)GTG>GCG	p.V111A	ADAMTSL1_uc003znb.2_Missense_Mutation_p.V111A|ADAMTSL1_uc003znc.3_Missense_Mutation_p.V111A	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	111						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		TGGCTTCCTGTGTCTAATGAC	0.498													41	108					0	0	0	0	C	18574122	C	C	18574122	3	2	296	1	0	0	0	0	1	0	0	0	274	1696	59	5	346	5	ADAMTSL1	9	18574122	Missense_Mutation	SNP	T	TCGA-H7-7774-01A-21D-2078-08		18574122	122639309	80	54820											
VCP	7415	broad.mit.edu	37	chr9	35059087	35059087	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgatgggtttgtctgcctctCtcgttctcgcctaatctcac	4	16	8	13	2	4	1	1	1	4	0	8	1	4	1	2	1	1	2	2	1	1	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:35059087C>T	uc003zvy.2	-	15	2523	c.2134G>A	c.(2134-2136)GAG>AAG	p.E712K	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.E381K|VCP_uc010mki.1_Missense_Mutation_p.E667K	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	712					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTCTGCCTCTCTCGTTCTCGC	0.552													21	54					0	0	0	0	T	35059087	T	T	35059087	3	4	296	1	0	0	0	0	1	0	0	0	17208	922	32	2	298	2	VCP	9	35059087	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	16484965	35059087	106154344	81	54821											
FBXO10	26267	broad.mit.edu	37	chr9	37518327	37518327	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatgctgttgttggccactCgggtgggttggctgctctgg	3	13	17	8	1	1	1	0	0	1	1	2	1	1	1	1	5	2	6	1	5	0	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:37518327C>T	uc004aab.2	-	9	2358	c.2309G>A	c.(2308-2310)CGA>CAA	p.R770Q	FBXO10_uc004aac.2_Missense_Mutation_p.R786Q|FBXO10_uc004aad.2_Missense_Mutation_p.R320Q	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	770	PbH1 15.					ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		GTTGGCCACTCGGGTGGGTTG	0.567													14	26					0	0	0	0	T	37518327	T	T	37518327	3	4	296	1	0	0	0	0	1	0	0	0	5758	884	31	1	573	1	FBXO10	9	37518327	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	2459240	37518327	103695104	82	54822											
DCAF10	79269	broad.mit.edu	37	chr9	37854962	37854962	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcccattttaagagcaagaaGaactacttcaagttcaggta	15	11	7	8	0	2	3	2	0	0	3	3	3	3	3	1	1	3	3	1	1	7	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:37854962G>A	uc004aao.2	+	4	1111	c.1037G>A	c.(1036-1038)AGA>AAA	p.R346K	DCAF10_uc010mlz.2_Missense_Mutation_p.R173K|DCAF10_uc004aap.2_Missense_Mutation_p.R34K	NM_024345	NP_077321	Q5QP82	DCA10_HUMAN	WD repeat domain 32	346						CUL4 RING ubiquitin ligase complex				central_nervous_system(1)	1						AGAGCAAGAAGAACTACTTCA	0.338													19	60					0	0	0	0	A	37854962	A	A	37854962	3	1	296	1	0	0	0	0	1	0	0	0	4278	942	33	2	1051	2	DCAF10	9	37854962	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	336635	37854962	103358469	83	54823											
GDA	9615	broad.mit.edu	37	chr9	74838108	74838108	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agactttgatgggtgaactgGgcaacattgctaaaacccgt	12	10	11	8	1	0	3	0	2	0	1	0	3	0	3	1	2	4	2	1	2	4	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:74838108G>A	uc004aiq.2	+	7	862	c.679G>A	c.(679-681)GGC>AGC	p.G227S	GDA_uc011lse.1_Missense_Mutation_p.G153S|GDA_uc011lsf.1_Missense_Mutation_p.G153S|GDA_uc004air.2_Missense_Mutation_p.G227S|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Intron|GDA_uc004ait.1_Missense_Mutation_p.G153S	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	227					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GGGTGAACTGGGCAACATTGC	0.418													15	63					0	0	0	0	A	74838108	A	A	74838108	3	1	296	1	0	0	0	0	1	0	0	0	6342	1232	43	4	705	4	GDA	9	74838108	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	36983146	74838108	66375323	84	54824											
TRPM6	140803	broad.mit.edu	37	chr9	77370340	77370340	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagagatgctgttttctcctGgctctggattcaactggtca	7	14	10	10	0	4	1	2	0	2	1	5	3	4	2	1	3	2	3	1	3	1	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:77370340G>A	uc004ajl.1	-	28	5073	c.4835C>T	c.(4834-4836)CCA>CTA	p.P1612L	TRPM6_uc004ajk.1_Missense_Mutation_p.P1607L|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.P563L|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.P568L	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1612	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTTTTCTCCTGGCTCTGGATT	0.423													26	66					0	0	0	0	A	77370340	A	A	77370340	3	1	296	1	0	0	0	0	1	0	0	0	16657	1348	47	4	1281	4	TRPM6	9	77370340	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	2532232	77370340	63843091	85	54825											
OR13C4	138804	broad.mit.edu	37	chr9	107288587	107288587	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttatagcagcttttacatCtttatttctcaagctataga	11	19	4	7	0	2	1	1	0	2	1	3	1	2	1	0	0	4	3	0	0	7	10			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:107288587C>G	uc011lvn.1	-	1	904	c.904G>C	c.(904-906)GAT>CAT	p.D302H		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCTTTTACATCTTTATTTCTC	0.378													5	70					0	0	0	0	G	107288587	G	G	107288587	3	3	296	1	0	0	0	0	1	0	0	0	10990	913	32	2	54	2	OR13C4	9	107288587	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	29918247	107288587	33924844	86	54826											
OR13C9	286362	broad.mit.edu	37	chr9	107380043	107380043	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgacaatccctgcaaaccagGacccaacagccatgggtaca	14	5	8	14	0	0	1	0	1	0	0	1	2	1	2	4	2	5	2	4	2	4	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:107380043G>T	uc011lvr.1	-	1	443	c.443C>A	c.(442-444)TCC>TAC	p.S148Y		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCAAACCAGGACCCAACAGC	0.448													14	103					9.05144e-12	9.9878e-12	1	0	T	107380043	T	T	107380043	3	4	296	1	0	0	0	0	1	0	0	0	10993	1174	41	2	516	2	OR13C9	9	107380043	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	91456	107380043	33833388	87	54827											
SVEP1	79987	broad.mit.edu	37	chr9	113139598	113139598	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cctctggacaggaacaagcaTttgggcgttggcagatgccc	9	8	13	11	1	1	1	0	0	1	1	1	3	1	3	2	4	3	3	2	4	2	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:113139598T>A	uc010mtz.2	-	45	10794	c.10457A>T	c.(10456-10458)AAT>ATT	p.N3486I	SVEP1_uc010mty.2_Missense_Mutation_p.N1412I	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3486					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GGAACAAGCATTTGGGCGTTG	0.502													18	42					0	0	0	0	A	113139598	A	A	113139598	3	1	296	1	0	0	0	0	1	0	0	0	15486	1493	52	5	274	5	SVEP1	9	113139598	Missense_Mutation	SNP	T	TCGA-H7-7774-01A-21D-2078-08	5759555	113139598	28073833	88	54828											
SVEP1	79987	broad.mit.edu	37	chr9	113170974	113170974	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ttgccagatttctgacatgtCcaagaactgtcaccaacaag	13	10	7	11	0	2	3	1	1	1	2	3	3	3	3	3	0	3	0	3	0	4	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:113170974C>T	uc010mtz.2	-	38	7243	c.6906G>A	c.(6904-6906)TGG>TGA	p.W2302*	SVEP1_uc010mty.2_Nonsense_Mutation_p.W228*	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2302	Sushi 15.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TCTGACATGTCCAAGAACTGT	0.443													17	59					0	0	0	0	T	113170974	T	T	113170974	4	4	296	1	0	0	0	0	0	1	0	0	15486	856	30	2	3853	2	SVEP1	9	113170974	Nonsense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	31376	113170974	28042457	89	54829											
ZNF883	169834	broad.mit.edu	37	chr9	115760171	115760171	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cattcattacaaggatagggTttttctccagtatggattct	10	16	8	7	0	3	0	1	0	2	0	4	2	3	2	1	3	1	2	1	3	4	7			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr9:115760171T>G	uc011lwy.1	-	5	1608	c.369A>C	c.(367-369)AAA>AAC	p.K123N		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGGATAGGGTTTTTCTCCAG	0.378													3	45					0	0	0	0	G	115760171	G	G	115760171	3	3	296	1	0	0	0	0	1	0	0	0	18265	1722	60	5	772	5	ZNF883	9	115760171	Missense_Mutation	SNP	T	TCGA-H7-7774-01A-21D-2078-08	2589197	115760171	25453260	90	54830											
LYZL2	119180	broad.mit.edu	37	chr10	30915048	30915048	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcacctgagcaggcgacgTggcagtggttgttctccttc	5	11	12	13	2	2	1	1	1	1	0	4	2	2	1	3	3	1	4	3	3	0	3	rs143775752	byFrequency	TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:30915048T>C	uc001ivk.2	-	3	435	c.422A>G	c.(421-423)CAC>CGC	p.H141R		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	95					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				GCAGGCGACGTGGCAGTGGTT	0.557													11	54					0	0	0	0	C	30915048	C	C	30915048	3	2	296	1	0	0	0	0	1	0	0	0	9183	1696	59	5	174	5	LYZL2	10	30915048	Missense_Mutation	SNP	T	TCGA-H7-7774-01A-21D-2078-08		30915048	104619699	91	54831											
ZNF438	220929	broad.mit.edu	37	chr10	31133973	31133973	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccacagtttggaagggtcctCacagttatgctggtgcttcc	7	12	11	11	0	1	0	1	0	0	0	3	1	3	1	3	3	2	4	3	3	2	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:31133973C>G	uc010qdz.1	-	8	2839	c.2404G>C	c.(2404-2406)GAG>CAG	p.E802Q	ZNF438_uc001ivn.2_Missense_Mutation_p.E753Q|ZNF438_uc010qdy.1_Missense_Mutation_p.E792Q|ZNF438_uc001ivo.3_Missense_Mutation_p.E366Q|ZNF438_uc009xlg.2_Missense_Mutation_p.E802Q|ZNF438_uc001ivp.3_Missense_Mutation_p.E792Q|ZNF438_uc010qea.1_Missense_Mutation_p.E802Q|ZNF438_uc010qeb.1_Missense_Mutation_p.E802Q	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	802					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				GAAGGGTCCTCACAGTTATGC	0.517													7	184					0	0	0	0	G	31133973	G	G	31133973	3	3	296	1	0	0	0	0	1	0	0	0	17977	835	29	2	86	2	ZNF438	10	31133973	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	218925	31133973	104400774	92	54832											
ANKRD30A	91074	broad.mit.edu	37	chr10	37506697	37506697	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aaaaattagggaagaattagGaagaatcgaagagcagcata	21	6	11	3	1	0	3	0	0	0	3	1	6	0	5	0	2	2	2	0	2	10	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:37506697G>C	uc001iza.1	+	33	3089	c.2990G>C	c.(2989-2991)GGA>GCA	p.G997A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1053	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GAAGAATTAGGAAGAATCGAA	0.318													3	40					0	0	0	0	C	37506697	C	C	37506697	3	2	296	1	0	0	0	0	1	0	0	0	658	1174	41	2	3120	2	ANKRD30A	10	37506697	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	6372724	37506697	98028050	93	54833											
ALOX5	240	broad.mit.edu	37	chr10	45941026	45941026	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggaagccatggcccgattccGcaagaacctcgaggccattg	10	6	12	13	3	0	1	0	0	0	1	2	4	1	2	5	3	2	1	5	3	3	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:45941026G>A	uc001jce.2	+	14	2015	c.1916G>A	c.(1915-1917)CGC>CAC	p.R639H	ALOX5_uc009xmt.2_Missense_Mutation_p.R607H|ALOX5_uc010qfg.1_Missense_Mutation_p.R582H	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	639	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	GCCCGATTCCGCAAGAACCTC	0.532													7	52					0	0	0	0	A	45941026	A	A	45941026	3	1	296	1	0	0	0	0	1	0	0	0	540	1087	38	1	1970	1	ALOX5	10	45941026	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	8434329	45941026	89593721	94	54834											
CTNNA3	29119	broad.mit.edu	37	chr10	67829147	67829147	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cgttgcttgtatcatcccatAtctcaatctcagcatccagc	9	13	5	14	1	3	0	3	0	2	0	7	0	5	0	2	0	3	4	2	0	3	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:67829147A>T	uc009xpn.1	-	15	2201	c.2078T>A	c.(2077-2079)ATA>AAA	p.I693K	CTNNA3_uc001jmw.2_Missense_Mutation_p.I693K	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	693					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						ATCATCCCATATCTCAATCTC	0.403													35	91					0	0	0	0	T	67829147	T	T	67829147	3	4	296	1	0	0	0	0	1	0	0	0	4031	449	16	5	625	5	CTNNA3	10	67829147	Missense_Mutation	SNP	A	TCGA-H7-7774-01A-21D-2078-08	21888121	67829147	67705600	95	54835											
WAPAL	23063	broad.mit.edu	37	chr10	88232379	88232379	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcttacttctttgtctTctcgtctgcatttcagtgca	4	18	8	11	1	5	0	1	0	4	0	6	0	5	0	0	1	4	4	0	1	1	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:88232379T>A	uc001kdo.2	-	6	2325	c.1883A>T	c.(1882-1884)GAA>GTA	p.E628V	WAPAL_uc009xsv.2_5'Flank|WAPAL_uc001kdn.2_Missense_Mutation_p.E665V|WAPAL_uc009xsw.2_Missense_Mutation_p.E622V	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	628	Mediates interaction with the cohesin complex.|WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						TTCTTTGTCTTCTCGTCTGCA	0.358													9	35					0	0	0	0	A	88232379	A	A	88232379	3	1	296	1	0	0	0	0	1	0	0	0	17316	1783	62	5	1745	5	WAPAL	10	88232379	Missense_Mutation	SNP	T	TCGA-H7-7774-01A-21D-2078-08	20403232	88232379	47302368	96	54836											
ZDHHC16	84287	broad.mit.edu	37	chr10	99211482	99211482	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccggcccgcctctgcctccGcctccttctgctgctgggtt	0	11	10	20	3	2	0	0	0	2	0	4	0	4	0	7	2	3	3	7	2	0	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:99211482G>A	uc001knj.2	+	3	399	c.50G>A	c.(49-51)CGC>CAC	p.R17H	ZDHHC16_uc001knp.2_Missense_Mutation_p.R17H|ZDHHC16_uc001knk.2_Missense_Mutation_p.R17H|ZDHHC16_uc001knl.2_Missense_Mutation_p.R17H|ZDHHC16_uc001knm.2_Missense_Mutation_p.R17H|ZDHHC16_uc001knn.2_Missense_Mutation_p.R17H|ZDHHC16_uc010qow.1_Missense_Mutation_p.R17H|ZDHHC16_uc009xvq.2_RNA|ZDHHC16_uc001kno.2_Missense_Mutation_p.R17H|ZDHHC16_uc009xvr.2_Missense_Mutation_p.R17H	NM_198046	NP_932163	Q969W1	ZDH16_HUMAN	Abl-philin 2 isoform 1	17	Cytoplasmic (Potential).				apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		CTCTGCCTCCGCCTCCTTCTG	0.667													16	23					0	0	0	0	A	99211482	A	A	99211482	3	1	296	1	0	0	0	0	1	0	0	0	17673	1087	38	1	52	1	ZDHHC16	10	99211482	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	10979103	99211482	36323265	97	54837											
SORCS3	22986	broad.mit.edu	37	chr10	106976783	106976783	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agccccatcgaggacggcatCaagcacgtgtataagagtgc	12	6	12	11	3	1	1	1	0	0	1	2	3	1	2	2	2	3	3	2	2	3	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:106976783C>G	uc001kyi.1	+	19	2864	c.2637C>G	c.(2635-2637)ATC>ATG	p.I879M	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	879	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGGACGGCATCAAGCACGTGT	0.517													13	35					0	0	0	0	G	106976783	G	G	106976783	3	3	296	1	0	0	0	0	1	0	0	0	14996	816	29	2	2711	2	SORCS3	10	106976783	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	7765301	106976783	28557964	98	54838											
GFRA1	2674	broad.mit.edu	37	chr10	117884986	117884986	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgcacggggtgatgtacgcCgacctgtacttcttgcaaat	8	11	12	10	3	1	1	0	1	1	0	1	2	1	1	2	2	4	4	2	2	3	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr10:117884986C>T	uc001lcj.2	-	6	1214	c.516G>A	c.(514-516)TCG>TCA	p.S172S	GFRA1_uc001lci.2_Silent_p.S167S|GFRA1_uc009xyr.2_Silent_p.S167S	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	172	2.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TGATGTACGCCGACCTGTACT	0.577													12	28					0	0	0	0	T	117884986	T	T	117884986	2	4	296	1	0	0	0	0	0	0	0	1	6384	639	23	1		1	GFRA1	10	117884986	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	10908203	117884986	17649761	99	54839											
PSMA1	5682	broad.mit.edu	37	chr11	14526746	14526746	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctggcttatcacttaatgttCcattggttcatcagcctttt	7	18	6	10	0	3	0	3	0	0	0	4	0	4	0	2	2	1	3	2	2	2	7			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:14526746C>T	uc001mlk.2	-	10	930	c.784G>A	c.(784-786)GAA>AAA	p.E262K	PSMA1_uc001mll.2_Missense_Mutation_p.E268K|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_Missense_Mutation_p.E237K	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	262					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						ACTTAATGTTCCATTGGTTCA	0.333													26	70					0	0	0	0	T	14526746	T	T	14526746	3	4	296	1	0	0	0	0	1	0	0	0	12728	864	30	2	11	2	PSMA1	11	14526746	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08		14526746	120479770	100	54840											
MRGPRX4	117196	broad.mit.edu	37	chr11	18195639	18195639	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cttcttcgtgggctcctttaGgcagcgtcaaaataggcaga	9	11	11	10	2	2	1	1	0	1	1	4	1	3	1	1	3	1	3	1	3	4	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:18195639G>C	uc001mnv.1	+	1	1256	c.836G>C	c.(835-837)AGG>ACG	p.R279T		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	279	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GGCTCCTTTAGGCAGCGTCAA	0.488													13	66					0	0	0	0	C	18195639	C	C	18195639	3	2	296	1	0	0	0	0	1	0	0	0	9822	1000	35	4	838	4	MRGPRX4	11	18195639	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	3668893	18195639	116810877	101	54841											
IGSF22	283284	broad.mit.edu	37	chr11	18735568	18735568	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtcacttccatgccatccttGtaccatgtcactttgggcag	7	13	8	13	0	2	0	2	0	0	0	4	0	4	0	4	1	2	2	4	1	1	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:18735568G>T	uc009yht.2	-	14	2116	c.1926C>A	c.(1924-1926)TAC>TAA	p.Y642*	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	642	Ig-like 4.									ovary(4)|large_intestine(2)|kidney(1)	7						TGCCATCCTTGTACCATGTCA	0.602													24	64					9.86323e-18	1.11396e-17	1	0	T	18735568	T	T	18735568	4	4	296	1	0	0	0	0	0	1	0	0	7639	1372	48	4	2094	4	IGSF22	11	18735568	Nonsense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	539929	18735568	116270948	102	54842											
ANO5	203859	broad.mit.edu	37	chr11	22257816	22257816	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tactcatctgcctatccactCcatgatgtatgtataggttt	9	16	6	10	0	2	1	1	1	1	0	4	1	4	1	3	1	2	3	3	1	5	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:22257816C>A	uc001mqi.2	+	8	1073	c.756C>A	c.(754-756)CTC>CTA	p.L252L	ANO5_uc001mqj.2_Silent_p.L251L	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	252	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						CCTATCCACTCCATGATGTAT	0.383													11	37					5.16669e-11	5.63639e-11	1	0	A	22257816	A	A	22257816	2	1	296	1	0	0	0	0	0	0	0	1	700	842	30	2		2	ANO5	11	22257816	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	3522248	22257816	112748700	103	54843											
TCP11L1	55346	broad.mit.edu	37	chr11	33083210	33083210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccaggctgagccctgttgctGtccagaattacgcttacctg	7	11	10	13	1	0	2	0	1	0	1	1	2	1	2	4	1	4	4	4	1	3	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:33083210G>A	uc001mud.2	+	7	1310	c.910G>A	c.(910-912)GTC>ATC	p.V304I	TCP11L1_uc009yju.2_Missense_Mutation_p.V119I|TCP11L1_uc010rei.1_Missense_Mutation_p.V304I|TCP11L1_uc001mue.2_Missense_Mutation_p.V304I|TCP11L1_uc001muf.1_RNA	NM_018393	NP_060863	Q9NUJ3	T11L1_HUMAN	t-complex 11 (mouse) like 1	304											0						CCCTGTTGCTGTCCAGAATTA	0.547													5	17					0	0	0	0	A	33083210	A	A	33083210	3	1	296	1	0	0	0	0	1	0	0	0	15780	1377	48	4	932	4	TCP11L1	11	33083210	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	10825394	33083210	101923306	104	54844											
OR4C11	219429	broad.mit.edu	37	chr11	55371357	55371357	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	caaatagggtccacagaaagGcaatcttaaggccaggataa	17	6	10	8	0	1	1	0	0	1	1	2	2	2	2	2	4	0	1	2	4	6	3	rs141808171	byFrequency	TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:55371357G>A	uc010rii.1	-	1	493	c.493C>T	c.(493-495)CCT>TCT	p.P165S		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCACAGAAAGGCAATCTTAAG	0.443													16	14					0	0	0	0	A	55371357	A	A	55371357	3	1	296	1	0	0	0	0	1	0	0	0	11099	1203	42	4	441	4	OR4C11	11	55371357	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	22288147	55371357	79635159	105	54845											
OR5D13	390142	broad.mit.edu	37	chr11	55541352	55541352	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agaagctctgtgctcttctgGtggctgggtcctatacatgg	6	13	13	9	0	3	1	0	0	3	1	4	1	4	1	1	4	3	3	1	4	3	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:55541352G>T	uc010ril.1	+	1	439	c.439G>T	c.(439-441)GTG>TTG	p.V147L		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TGCTCTTCTGGTGGCTGGGTC	0.403													15	137					1.99824e-07	2.13145e-07	1	0	T	55541352	T	T	55541352	3	4	296	1	0	0	0	0	1	0	0	0	11208	1261	44	4	441	4	OR5D13	11	55541352	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	169995	55541352	79465164	106	54846											
PC	5091	broad.mit.edu	37	chr11	66617416	66617416	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccttccctaccttagagcGaaagggttcggggaaccccc	8	7	12	14	2	0	1	0	0	0	1	2	3	1	2	5	4	3	1	5	4	4	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:66617416G>A	uc001ojn.1	-	18	2939	c.2890C>T	c.(2890-2892)CGC>TGC	p.R964C	PC_uc001ojo.1_Missense_Mutation_p.R964C|PC_uc001ojp.1_Missense_Mutation_p.R964C|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	964					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	ACCTTAGAGCGAAAGGGTTCG	0.627													10	31					0	0	0	0	A	66617416	A	A	66617416	3	1	296	1	0	0	0	0	1	0	0	0	11551	1058	37	1	662	1	PC	11	66617416	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	11076064	66617416	68389100	107	54847											
OR2AT4	341152	broad.mit.edu	37	chr11	74800175	74800175	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtctggggggtggtgtcaGagcaggaggcctggaccaca	7	6	20	8	0	2	1	1	0	1	1	2	3	2	3	2	8	1	1	2	8	0	0			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:74800175G>C	uc010rro.1	-	1	584	c.584C>G	c.(583-585)TCT>TGT	p.S195C		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTGGTGTCAGAGCAGGAGGC	0.567													3	34					0	0	0	0	C	74800175	C	C	74800175	3	2	296	1	0	0	0	0	1	0	0	0	11041	942	33	2	381	2	OR2AT4	11	74800175	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	8182759	74800175	60206341	108	54848											
CUL5	8065	broad.mit.edu	37	chr11	107925516	107925516	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtgtacagaattatatgaaAtatgtaagttagaacttagt	16	14	9	2	0	0	3	0	1	0	2	0	3	0	3	0	1	2	3	0	1	10	7			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:107925516A>T	uc001pjv.2	+	6	1363	c.696A>T	c.(694-696)AAA>AAT	p.K232N	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	232					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		ATTATATGAAATATGTAAGTT	0.323													15	25					0	0	0	0	T	107925516	T	T	107925516	3	4	296	1	0	0	0	0	1	0	0	0	4076	98	4	5	718	5	CUL5	11	107925516	Missense_Mutation	SNP	A	TCGA-H7-7774-01A-21D-2078-08	33125341	107925516	27081000	109	54849											
OR10S1	219873	broad.mit.edu	37	chr11	123848324	123848324	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctcaaaccctccaggaaGaagtggctcaccacagtctg	12	7	8	14	0	3	1	2	0	1	1	4	2	4	2	4	2	2	1	4	2	4	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:123848324G>A	uc001pzm.1	-	1	75	c.75C>T	c.(73-75)TTC>TTT	p.F25F		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCTCCAGGAAGAAGTGGCTCA	0.502													6	77					0	0	0	0	A	123848324	A	A	123848324	2	1	296	1	0	0	0	0	0	0	0	1	10972	933	33	2		2	OR10S1	11	123848324	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	15922808	123848324	11158192	110	54850											
NFRKB	4798	broad.mit.edu	37	chr11	129746654	129746654	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtaggcaggccggtcggagCgcagcagggagtgctcccga	7	4	18	12	5	0	0	0	0	0	0	2	3	1	2	2	5	3	5	2	5	1	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr11:129746654C>T	uc001qfi.2	-	17	1910	c.1709G>A	c.(1708-1710)CGC>CAC	p.R570H	NFRKB_uc001qfg.2_Missense_Mutation_p.R595H|NFRKB_uc001qfh.2_Missense_Mutation_p.R593H|NFRKB_uc010sbw.1_Missense_Mutation_p.R580H|NFRKB_uc009zcr.2_5'Flank	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	570					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		CCGGTCGGAGCGCAGCAGGGA	0.572													8	37					0	0	0	0	T	129746654	T	T	129746654	3	4	296	1	0	0	0	0	1	0	0	0	10438	768	27	1	2234	1	NFRKB	11	129746654	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	5898330	129746654	5259862	111	54851											
COPS7A	50813	broad.mit.edu	37	chr12	6839587	6839587	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgtgtgggctgtgaggtcGtgctgtcaggcattgaggag	5	11	20	5	1	1	2	1	2	0	0	2	3	1	3	0	5	1	3	0	5	0	1	rs144125600		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:6839587G>A	uc001qqj.2	+	6	789	c.550G>A	c.(550-552)GTG>ATG	p.V184M	COPS7A_uc009zex.2_RNA|COPS7A_uc001qqk.2_Missense_Mutation_p.V184M|COPS7A_uc001qql.2_RNA|COPS7A_uc001qqh.2_Missense_Mutation_p.V184M|COPS7A_uc001qqi.2_Missense_Mutation_p.V184M|COPS7A_uc001qqm.2_RNA|COPS7A_uc001qqn.3_Missense_Mutation_p.V184M|COPS7A_uc001qqo.2_Missense_Mutation_p.V184M	NM_001164094	NP_001157566	Q9UBW8	CSN7A_HUMAN	COP9 complex subunit 7a	184					cullin deneddylation	cytoplasm|signalosome				ovary(1)	1						CTGTGAGGTCGTGCTGTCAGG	0.567													4	73					0	0	0	0	A	6839587	A	A	6839587	3	1	296	1	0	0	0	0	1	0	0	0	3753	1145	40	1	568	1	COPS7A	12	6839587	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08		6839587	127012308	112	54852											
ITPR2	3709	broad.mit.edu	37	chr12	26493141	26493141	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgacccgacagctgtttgaCcagactcatggtcgattcca	9	10	9	13	2	1	3	1	2	0	1	3	5	2	3	3	1	1	2	3	1	0	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:26493141C>T	uc001rhg.2	-	56	8395	c.7978G>A	c.(7978-7980)GTC>ATC	p.V2660I		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2660	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AGCTGTTTGACCAGACTCATG	0.547													18	35					0	0	0	0	T	26493141	T	T	26493141	3	4	296	1	0	0	0	0	1	0	0	0	7960	507	18	4	135	4	ITPR2	12	26493141	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	19653554	26493141	107358754	113	54853											
ITPR2	3709	broad.mit.edu	37	chr12	26572049	26572049	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccaggacatacgccacgtgaTagagaaaggccatatccagg	14	5	11	11	2	0	2	0	1	0	1	1	4	1	3	4	3	1	0	4	3	4	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:26572049T>C	uc001rhg.2	-	50	7460	c.7043A>G	c.(7042-7044)TAT>TGT	p.Y2348C	ITPR2_uc009zjg.1_Missense_Mutation_p.Y499C	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2348	Extracellular (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					CGCCACGTGATAGAGAAAGGC	0.453													19	51					0	0	0	0	C	26572049	C	C	26572049	3	2	296	1	0	0	0	0	1	0	0	0	7960	1406	49	5	1094	5	ITPR2	12	26572049	Missense_Mutation	SNP	T	TCGA-H7-7774-01A-21D-2078-08	78908	26572049	107279846	114	54854											
PPFIBP1	8496	broad.mit.edu	37	chr12	27826759	27826759	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gaagaaagagacatctgatgGggtgggttctgtgttttttg	9	14	15	3	0	2	3	0	1	2	2	2	5	2	3	0	3	0	2	0	3	2	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:27826759G>T	uc001ric.1	+	16	1807	c.1430G>T	c.(1429-1431)GGG>GTG	p.G477V	PPFIBP1_uc010sjr.1_Missense_Mutation_p.G308V|PPFIBP1_uc001rib.1_Missense_Mutation_p.G460V|PPFIBP1_uc001ria.2_Missense_Mutation_p.G446V|PPFIBP1_uc001rid.1_Missense_Mutation_p.G324V|PPFIBP1_uc001rif.1_5'Flank	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	477					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					ACATCTGATGGGGTGGGTTCT	0.348													11	41					5.16669e-11	5.63639e-11	1	0	T	27826759	T	T	27826759	3	4	296	1	0	0	0	0	1	0	0	0	12368	1246	43	4	1475	4	PPFIBP1	12	27826759	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	1254710	27826759	106025136	115	54855											
ALG10	84920	broad.mit.edu	37	chr12	34179307	34179307	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cattttcctcaactattctaCtttttttcatttactctctt	7	23	0	11	0	4	0	2	0	2	0	6	0	5	0	1	0	3	0	1	0	4	11			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:34179307C>T	uc001rlm.2	+	3	1198	c.879C>T	c.(877-879)TAC>TAT	p.Y293Y		NM_032834	NP_116223	Q5BKT4	AG10A_HUMAN	asparagine-linked glycosylation 10 homolog	293	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			skin(1)	1	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				AACTATTCTACTTTTTTTCAT	0.348													43	111					0	0	0	0	T	34179307	T	T	34179307	2	4	296	1	0	0	0	0	0	0	0	1	511	576	20	4		4	ALG10	12	34179307	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	6352548	34179307	99672588	116	54856											
KRT5	3852	broad.mit.edu	37	chr12	52913978	52913979	+	Frame_Shift_Ins	INS	-	GG	GG																															ccacccccggaccgggacacINSggaggtgaagctggtgcggg																										TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:52913978_52913979insGG	uc001san.2	-	1	265_266	c.102_103insCC	c.(100-105)TCCGTGfs	p.S34fs	KRT5_uc009zmh.2_Frame_Shift_Ins_p.S34fs	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	34_35	Head.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		GACCGGGACACGGAGGTGAAGC	0.663													---	---	---								GG	52913979	GG	GG	52913978	7	5	296	1	0	1	1	0	0	0	0	0	8518	536	19	0	1705	0	KRT5	12	52913978	Frame_Shift_Ins	INS	-	TCGA-H7-7774-01A-21D-2078-08	18734671	52913978	80937917	117	54857											
OR6C65	403282	broad.mit.edu	37	chr12	55794794	55794794	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttttccccccgtgattatggGcctccaactggatttttgtg	5	16	9	11	1	0	1	0	1	0	0	2	2	2	2	5	2	1	0	5	2	2	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr12:55794794G>A	uc010spl.1	+	1	482	c.482G>A	c.(481-483)GGC>GAC	p.G161D		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	161	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTGATTATGGGCCTCCAACTG	0.433													75	163					0	0	0	0	A	55794794	A	A	55794794	3	1	296	1	0	0	0	0	1	0	0	0	11249	1203	42	4	484	4	OR6C65	12	55794794	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	2880816	55794794	78057101	118	54858											
PDX1	3651	broad.mit.edu	37	chr13	28498614	28498614	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aggaggaggacaagaagcgcGgcggcgggacagctgtcggg	10	2	21	8	5	0	1	0	0	0	1	1	5	0	5	0	7	2	1	0	7	2	0			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr13:28498614G>A	uc001urt.2	+	2	736	c.628G>A	c.(628-630)GGC>AGC	p.G210S		NM_000209	NP_000200	P52945	PDX1_HUMAN	pancreatic and duodenal homeobox 1	210				GG -> SS (in Ref. 6; AAC05157).	detection of glucose|generation of precursor metabolites and energy|insulin secretion|nitric oxide mediated signal transduction|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|type B pancreatic cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0	all_cancers(110;0.175)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		CAAGAAGCGCGGCGGCGGGAC	0.582													7	16					0	0	0	0	A	28498614	A	A	28498614	3	1	296	1	0	0	0	0	1	0	0	0	11749	1116	39	1	634	1	PDX1	13	28498614	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08		28498614	86671264	119	54859											
DIS3	22894	broad.mit.edu	37	chr13	73349468	73349468	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagctccacagccacaatatCttcgtgaacagctctgttta	12	11	6	12	1	2	1	0	1	2	0	4	1	3	1	2	0	4	3	2	0	5	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr13:73349468C>G	uc001vix.3	-	6	1242	c.868G>C	c.(868-870)GAT>CAT	p.D290H	DIS3_uc001viy.3_Missense_Mutation_p.D260H|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	290					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		GCCACAATATCTTCGTGAACA	0.388										Multiple Myeloma(4;0.011)			18	65					0	0	0	0	G	73349468	G	G	73349468	3	3	296	1	0	0	0	0	1	0	0	0	4557	913	32	2	2072	2	DIS3	13	73349468	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	44850854	73349468	41820410	120	54860											
MYCBP2	23077	broad.mit.edu	37	chr13	77651324	77651324	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactcgcagagtctcagcttCacagttcctctgctgggcca	7	11	9	14	1	3	1	2	0	2	1	6	1	4	1	2	1	3	4	2	1	1	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr13:77651324C>T	uc001vkf.2	-	68	11660	c.11569G>A	c.(11569-11571)GAA>AAA	p.E3857K	MYCBP2_uc010aev.2_Missense_Mutation_p.E3261K|MYCBP2_uc001vke.2_Missense_Mutation_p.E477K	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3857	DOC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GTCTCAGCTTCACAGTTCCTC	0.433													14	33					0	0	0	0	T	77651324	T	T	77651324	3	4	296	1	0	0	0	0	1	0	0	0	10071	835	29	2	2421	2	MYCBP2	13	77651324	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	4301856	77651324	37518554	121	54861											
SLITRK1	114798	broad.mit.edu	37	chr13	84455029	84455029	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tatcctctagcaggatctccGcaataccagggatttgctcc	9	11	8	13	1	2	0	0	0	2	0	5	2	4	2	4	2	3	3	4	2	4	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr13:84455029G>A	uc001vlk.2	-	1	1500	c.614C>T	c.(613-615)GCG>GTG	p.A205V		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	205	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CAGGATCTCCGCAATACCAGG	0.542													22	39					0	0	0	0	A	84455029	A	A	84455029	3	1	296	1	0	0	0	0	1	0	0	0	14806	1087	38	1	1480	1	SLITRK1	13	84455029	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	6803705	84455029	30714849	122	54862											
CHD8	57680	broad.mit.edu	37	chr14	21873943	21873943	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gattctgagggaaattgtgaCggttccaagaaatgaagcaa	15	9	12	5	1	1	4	0	3	1	1	2	6	2	5	1	2	1	2	1	2	5	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr14:21873943C>T	uc001was.1	-	15	2245	c.2151G>A	c.(2149-2151)CCG>CCA	p.P717P	CHD8_uc001war.1_Silent_p.P613P|CHD8_uc001wav.1_Silent_p.P159P	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	996	Helicase ATP-binding.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GAAATTGTGACGGTTCCAAGA	0.418													8	130					0	0	0	0	T	21873943	T	T	21873943	2	4	296	1	0	0	0	0	0	0	0	1	3346	523	19	1		1	CHD8	14	21873943	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08		21873943	85475597	123	54863											
NPAS3	64067	broad.mit.edu	37	chr14	34263139	34263139	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtgtgtgacaaagtactatcGctggatgcagaagaacggag	13	8	14	6	2	0	3	0	1	0	2	1	5	0	5	0	2	3	3	0	2	5	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr14:34263139G>A	uc001wru.2	+	10	1254	c.1190G>A	c.(1189-1191)CGC>CAC	p.R397H	NPAS3_uc001wrs.2_Missense_Mutation_p.R384H|NPAS3_uc001wrt.2_Missense_Mutation_p.R365H|NPAS3_uc001wrv.2_Missense_Mutation_p.R367H	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	397	PAC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		AAGTACTATCGCTGGATGCAG	0.373													10	47					0	0	0	0	A	34263139	A	A	34263139	3	1	296	1	0	0	0	0	1	0	0	0	10618	1087	38	1	1283	1	NPAS3	14	34263139	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	12389196	34263139	73086401	124	54864											
ITPK1	3705	broad.mit.edu	37	chr14	93408122	93408122	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accaggccgcccgccggctcGgccagaagcttgctgtgcct	5	6	13	17	4	0	1	0	0	0	1	1	1	0	1	6	3	3	3	6	3	1	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr14:93408122G>A	uc001ybg.2	-	11	1318	c.1029C>T	c.(1027-1029)GCC>GCT	p.A343A	ITPK1_uc001ybe.2_Intron|ITPK1_uc001ybf.2_Silent_p.A224A|ITPK1_uc001ybh.2_Silent_p.A343A	NM_014216	NP_055031	Q13572	ITPK1_HUMAN	inositol 1,3,4-triphosphate 5/6 kinase isoform	343					blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding				0		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		CCGCCGGCTCGGCCAGAAGCT	0.711													4	14					0	0	0	0	A	93408122	A	A	93408122	2	1	296	1	0	0	0	0	0	0	0	1	7955	1103	39	1		1	ITPK1	14	93408122	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	59144983	93408122	13941418	125	54865											
ITPK1	3705	broad.mit.edu	37	chr14	93412800	93412800	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagagctcccggatgacctcGtcgctcggccgctcgaacac	7	6	12	16	6	0	2	0	1	0	1	5	5	1	3	3	2	2	3	3	2	1	0	rs144084022		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr14:93412800G>T	uc001ybg.2	-	10	1066	c.777C>A	c.(775-777)GAC>GAA	p.D259E	ITPK1_uc001ybe.2_Missense_Mutation_p.D259E|ITPK1_uc001ybf.2_Missense_Mutation_p.D140E|ITPK1_uc001ybh.2_Missense_Mutation_p.D259E	NM_014216	NP_055031	Q13572	ITPK1_HUMAN	inositol 1,3,4-triphosphate 5/6 kinase isoform	259	ATP-grasp.				blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding				0		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		GGATGACCTCGTCGCTCGGCC	0.637													5	41					0.000602214	0.000611773	1	0	T	93412800	T	T	93412800	3	4	296	1	0	0	0	0	1	0	0	0	7955	1136	40	3	523	3	ITPK1	14	93412800	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	4678	93412800	13936740	126	54866											
AHNAK2	113146	broad.mit.edu	37	chr14	105409647	105409647	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accttgggcaggtgccctttGaggctggctccctcgggcac	4	9	14	14	1	0	1	0	1	0	0	2	1	1	1	3	5	1	4	3	5	0	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr14:105409647G>C	uc010axc.1	-	7	12261	c.12141C>G	c.(12139-12141)CTC>CTG	p.L4047L	AHNAK2_uc001ypx.2_Silent_p.L3947L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4047						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGTGCCCTTTGAGGCTGGCTC	0.627													9	200					0	0	0	0	C	105409647	C	C	105409647	2	2	296	1	0	0	0	0	0	0	0	1	415	1277	45	2		2	AHNAK2	14	105409647	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	11996847	105409647	1939893	127	54867											
RYR3	6263	broad.mit.edu	37	chr15	33962690	33962690	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaaaactctgtgccttggtTtacaaaatcaaaggcccacc	13	9	8	11	0	2	0	1	0	1	0	2	1	2	1	3	3	3	1	3	3	6	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:33962690T>G	uc001zhi.2	+	38	5863	c.5793T>G	c.(5791-5793)GTT>GTG	p.V1931V	RYR3_uc010bar.2_Silent_p.V1931V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1931	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTGCCTTGGTTTACAAAATCA	0.448													10	35					0	0	0	0	G	33962690	G	G	33962690	2	3	296	1	0	0	0	0	0	0	0	1	13835	1828	64	5		5	RYR3	15	33962690	Silent	SNP	T	TCGA-H7-7774-01A-21D-2078-08		33962690	68568702	128	54868											
MAP1A	4130	broad.mit.edu	37	chr15	43815140	43815140	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtcaaaatagacaggagccGtgctatccgtggggagaagg	13	6	15	7	2	1	2	1	0	0	2	2	4	2	3	2	4	2	1	2	4	5	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:43815140G>A	uc001zrt.2	+	4	1936	c.1469G>A	c.(1468-1470)CGT>CAT	p.R490H		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	490	Lys-rich (basic).|9 X 3 AA repeats of K-K-[DE].					cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GACAGGAGCCGTGCTATCCGT	0.542													10	12					0	0	0	0	A	43815140	A	A	43815140	3	1	296	1	0	0	0	0	1	0	0	0	9280	1145	40	1	1471	1	MAP1A	15	43815140	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	9852450	43815140	58716252	129	54869											
USP8	9101	broad.mit.edu	37	chr15	50763974	50763974	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaacaactctccggagtctGaaagatgcacttttcaaggt	12	10	10	9	1	3	2	1	1	2	1	4	4	3	4	1	3	3	1	1	3	4	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:50763974G>C	uc001zym.3	+	9	1331	c.831G>C	c.(829-831)CTG>CTC	p.L277L	USP8_uc001zyk.1_5'UTR|USP8_uc001zyl.3_Silent_p.L277L|USP8_uc001zyn.3_Silent_p.L277L|USP8_uc010ufh.1_Silent_p.L200L|USP8_uc010bev.1_Intron	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	277	Rhodanese.				cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TCCGGAGTCTGAAAGATGCAC	0.393													4	103					0	0	0	0	C	50763974	C	C	50763974	2	2	296	1	0	0	0	0	0	0	0	1	17157	1277	45	2		2	USP8	15	50763974	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	6948834	50763974	51767418	130	54870											
PRTG	283659	broad.mit.edu	37	chr15	55931991	55931991	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cttcgcatagagatggtgggGtggtggtggaggagggacca	8	8	20	5	1	0	1	0	0	0	1	1	5	0	4	1	8	0	1	1	8	1	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:55931991G>A	uc002adg.2	-	13	2221	c.2173C>T	c.(2173-2175)CCC>TCC	p.P725S		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	725	Fibronectin type-III 4.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		AGATGGTGGGGTGGTGGTGGA	0.448													6	63					0	0	0	0	A	55931991	A	A	55931991	3	1	296	1	0	0	0	0	1	0	0	0	12700	1261	44	4	1311	4	PRTG	15	55931991	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	5168017	55931991	46599401	131	54871											
DPP8	54878	broad.mit.edu	37	chr15	65793046	65793046	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	taatcgtaagaagcaattccGactgttccaatgcgttttct	11	14	7	9	3	1	1	0	0	1	1	4	2	3	1	2	0	2	4	2	0	5	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:65793046G>A	uc002aov.2	-	4	2070	c.492C>T	c.(490-492)GTC>GTT	p.V164V	DPP8_uc002aow.2_Silent_p.V164V|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Silent_p.V148V|DPP8_uc002aoy.2_Silent_p.V164V|DPP8_uc002aoz.2_Silent_p.V148V|DPP8_uc010bhj.2_Silent_p.V164V|DPP8_uc002apa.2_Silent_p.V61V	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	164					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						AAGCAATTCCGACTGTTCCAA	0.398													40	82					0	0	0	0	A	65793046	A	A	65793046	2	1	296	1	0	0	0	0	0	0	0	1	4754	1045	37	1		1	DPP8	15	65793046	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	9861055	65793046	36738346	132	54872											
MYO9A	4649	broad.mit.edu	37	chr15	72119040	72119040	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggggtctctttggttttctGaggtgagtttttcacattct	4	20	11	6	0	4	2	1	2	3	0	5	2	4	2	0	4	0	2	0	4	0	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:72119040G>A	uc002atl.3	-	42	8001	c.7528C>T	c.(7528-7530)CAG>TAG	p.Q2510*	MYO9A_uc002atj.2_Nonsense_Mutation_p.Q441*|MYO9A_uc002atk.2_Nonsense_Mutation_p.Q1305*	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	2510	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TTGGTTTTCTGAGGTGAGTTT	0.478													36	87					0	0	0	0	A	72119040	A	A	72119040	4	1	296	1	0	0	0	0	0	1	0	0	10137	1299	45	2	122	2	MYO9A	15	72119040	Nonsense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	6325994	72119040	30412352	133	54873											
ADPGK	83440	broad.mit.edu	37	chr15	73048712	73048712	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaacacctccagcatattCatggccccgttggagaggtc	11	8	9	13	1	1	1	1	0	0	1	3	2	2	1	4	3	2	2	4	3	2	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:73048712C>T	uc002avg.3	-	5	814	c.720G>A	c.(718-720)ATG>ATA	p.M240I	ADPGK_uc002ave.3_5'UTR|ADPGK_uc010ukw.1_Missense_Mutation_p.M182I|ADPGK_uc002avf.3_Missense_Mutation_p.M240I|ADPGK_uc002avi.3_Missense_Mutation_p.M118I|ADPGK_uc002avh.3_Missense_Mutation_p.M1I	NM_031284	NP_112574	Q9BRR6	ADPGK_HUMAN	ADP-dependent glucokinase	240	ADPK.				glycolysis	extracellular region	ADP-specific glucokinase activity|metal ion binding				0						CCAGCATATTCATGGCCCCGT	0.537													5	63					0	0	0	0	T	73048712	T	T	73048712	3	4	296	1	0	0	0	0	1	0	0	0	330	826	29	2	782	2	ADPGK	15	73048712	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	929672	73048712	29482680	134	54874											
RLBP1	6017	broad.mit.edu	37	chr15	89754989	89754989	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcacctggagcatgtccacCatcttcctgagatctgaagt	9	11	8	13	0	3	2	1	2	2	1	5	4	5	3	4	1	1	1	4	1	1	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:89754989C>T	uc002bnl.2	-	7	1049	c.669G>A	c.(667-669)ATG>ATA	p.M223I		NM_000326	NP_000317	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	223	CRAL-TRIO.				response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)	1	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	GCATGTCCACCATCTTCCTGA	0.547													3	40					0	0	0	0	T	89754989	T	T	89754989	3	4	296	1	0	0	0	0	1	0	0	0	13453	594	21	4	296	4	RLBP1	15	89754989	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	16706277	89754989	12776403	135	54875											
VPS33B	26276	broad.mit.edu	37	chr15	91542965	91542965	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagaatgtacaaccacccaaGaacaccaccaagatgaggcg	17	3	9	12	1	0	4	0	1	0	3	0	5	0	4	4	1	3	1	4	1	6	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr15:91542965G>C	uc002bqp.1	-	22	2070	c.1716C>G	c.(1714-1716)TTC>TTG	p.F572L	VPS33B_uc002bqq.1_Missense_Mutation_p.F481L|VPS33B_uc010uqu.1_Missense_Mutation_p.F545L	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	572					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					AACCACCCAAGAACACCACCA	0.507													8	216					0	0	0	0	C	91542965	C	C	91542965	3	2	296	1	0	0	0	0	1	0	0	0	17270	933	33	2	145	2	VPS33B	15	91542965	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	1787976	91542965	10988427	136	54876											
IFT140	9742	broad.mit.edu	37	chr16	1614075	1614075	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggcgtctcctgcacggcttCgcatacaaacagccggggct	7	7	12	15	5	1	0	0	0	1	0	3	0	1	0	2	4	4	4	2	4	2	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:1614075C>T	uc002cmb.2	-	17	2352	c.1990G>A	c.(1990-1992)GAA>AAA	p.E664K	IFT140_uc002clz.2_Missense_Mutation_p.E315K	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	664										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				TGCACGGCTTCGCATACAAAC	0.577													5	53					0	0	0	0	T	1614075	T	T	1614075	3	4	296	1	0	0	0	0	1	0	0	0	7595	893	31	1	2458	1	IFT140	16	1614075	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08		1614075	88740678	137	54877											
CREBBP	1387	broad.mit.edu	37	chr16	3820572	3820572	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagagacagagaggcttaccGgtgtgccaggaggctgggcg	9	5	18	9	2	0	2	0	0	0	2	0	5	0	3	2	5	2	2	2	5	1	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:3820572G>C	uc002cvv.2	-	14	3083	c.2879C>G	c.(2878-2880)CCG>CGG	p.P960R	CREBBP_uc002cvw.2_Missense_Mutation_p.P922R	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	960					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GAGGCTTACCGGTGTGCCAGG	0.488			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				54	221					0	0	0	0	C	3820572	C	C	3820572	3	2	296	1	0	0	0	0	1	0	0	0	3876	1130	39	3	4521	3	CREBBP	16	3820572	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	2206497	3820572	86534181	138	54878											
ACSM2B	348158	broad.mit.edu	37	chr16	20565237	20565237	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagtgatgagtggtggatGcctcactgacaaagacacag	13	7	12	9	0	1	4	1	3	0	1	1	5	1	5	1	2	1	0	1	2	1	0			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:20565237G>A	uc002dhj.3	-	6	812	c.602C>T	c.(601-603)GCA>GTA	p.A201V	ACSM2B_uc002dhk.3_Missense_Mutation_p.A201V|ACSM2B_uc010bwf.1_Missense_Mutation_p.A201V	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	201					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						AGTGGTGGATGCCTCACTGAC	0.493													14	44					0	0	0	0	A	20565237	A	A	20565237	3	1	296	1	0	0	0	0	1	0	0	0	184	1319	46	4	1171	4	ACSM2B	16	20565237	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	16744665	20565237	69789516	139	54879											
FHOD1	29109	broad.mit.edu	37	chr16	67263809	67263809	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tctcatctgatgtatcactgGgtaaactggagcctgggggt	8	12	13	8	0	3	1	2	1	2	0	4	2	3	2	1	4	2	2	1	4	3	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:67263809G>T	uc002esl.2	-	21	3411	c.3299C>A	c.(3298-3300)CCC>CAC	p.P1100H	LRRC29_uc002esf.2_5'Flank|LRRC29_uc002esg.2_5'Flank|LRRC29_uc010vjg.1_5'Flank|FHOD1_uc002esk.2_Missense_Mutation_p.P159H|FHOD1_uc010ced.2_Missense_Mutation_p.P907H	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1100					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TGTATCACTGGGTAAACTGGA	0.587													20	50					7.45023e-12	8.31653e-12	1	0	T	67263809	T	T	67263809	3	4	296	1	0	0	0	0	1	0	0	0	5914	1232	43	4	203	4	FHOD1	16	67263809	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	46698572	67263809	23090944	140	54880											
CTCF	10664	broad.mit.edu	37	chr16	67663349	67663361	+	Frame_Shift_Del	DEL	GAGGGGGAAAATG	-	-																															gtgctggcccagatggcgtaGagggggaaaatggaggagaa																										TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:67663349_67663361delGAGGGGGAAAATG	uc002etl.2	+	10	2040_2052	c.1750_1762delGAGGGGGAAAATG	c.(1750-1764)GAGGGGGAAAATGGAfs	p.E584fs	CTCF_uc010cek.2_Frame_Shift_Del_p.E256fs|CTCF_uc002etm.1_Frame_Shift_Del_p.E73fs	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	584_588					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		AGATGGCGTAGAGGGGGAAAATGGAGGAGAAAC	0.413													---	---	---								-	67663361	-	-	67663349	7	5	296	1	0	1	0	1	0	0	0	0	4017	943	33	0	1780	0	CTCF	16	67663349	Frame_Shift_Del	DEL	GAGGGGGAAAATG	TCGA-H7-7774-01A-21D-2078-08	399540	67663349	22691404	141	54881											
PRMT7	54496	broad.mit.edu	37	chr16	68390961	68390961	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gctcttcttcctacagggggGctgctgctggaacccccact	5	10	11	15	0	2	0	0	0	2	0	3	1	3	1	3	4	4	4	3	4	2	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr16:68390961G>A	uc002evy.1	+	19	2189	c.1913G>A	c.(1912-1914)GGC>GAC	p.G638D	PRMT7_uc010vlg.1_Missense_Mutation_p.G588D|PRMT7_uc002evz.1_Missense_Mutation_p.G410D	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	638					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CTACAGGGGGGCTGCTGCTGG	0.632													4	28					0	0	0	0	A	68390961	A	A	68390961	3	1	296	1	0	0	0	0	1	0	0	0	12603	1203	42	4	1979	4	PRMT7	16	68390961	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	727612	68390961	21963792	142	54882											
TUSC5	286753	broad.mit.edu	37	chr17	1183494	1183494	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tacccttcaaggccatctccGaggggcacctggaggcccca	8	6	11	16	1	2	0	1	0	1	0	3	2	2	1	6	5	1	1	6	5	2	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:1183494G>A	uc002fsi.1	+	1	538	c.199G>A	c.(199-201)GAG>AAG	p.E67K		NM_172367	NP_758955	Q8IXB3	TUSC5_HUMAN	LOST1	67					response to biotic stimulus	integral to membrane				skin(2)	2				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGCCATCTCCGAGGGGCACCT	0.632													17	54					0	0	0	0	A	1183494	A	A	1183494	3	1	296	1	0	0	0	0	1	0	0	0	16847	1059	37	1	201	1	TUSC5	17	1183494	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08		1183494	80011716	143	54883											
MYO1C	4641	broad.mit.edu	37	chr17	1387576	1387576	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgcactctccatggtcacccGaaccccgtcactgcccaggg	7	6	9	19	3	3	0	2	0	1	0	4	1	3	0	5	2	2	1	5	2	1	0			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:1387576G>A	uc002fsp.2	-	2	317	c.97C>T	c.(97-99)CGG>TGG	p.R33W	MYO1C_uc002fsn.2_Missense_Mutation_p.R14W|MYO1C_uc002fso.2_5'UTR|MYO1C_uc010vqj.1_5'UTR|MYO1C_uc010vqk.1_Missense_Mutation_p.R9W	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	33					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		ATGGTCACCCGAACCCCGTCA	0.652													6	24					0	0	0	0	A	1387576	A	A	1387576	3	1	296	1	0	0	0	0	1	0	0	0	10123	1057	37	1	3218	1	MYO1C	17	1387576	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	204082	1387576	79807634	144	54884											
WSCD1	23302	broad.mit.edu	37	chr17	5998441	5998441	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcggaccgccacctaccgCggatgcttccgactgccaga	7	5	13	16	5	0	1	0	0	0	1	1	4	1	3	6	3	3	1	6	3	1	2	rs148922288		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:5998441C>T	uc010cli.2	+	5	1126	c.747C>T	c.(745-747)CGC>CGT	p.R249R	WSCD1_uc002gcn.2_Silent_p.R249R|WSCD1_uc002gco.2_Silent_p.R249R|WSCD1_uc010clj.2_5'UTR	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	249	WSC 2.					integral to membrane	sulfotransferase activity				0						CCACCTACCGCGGATGCTTCC	0.572													18	82					0	0	0	0	T	5998441	T	T	5998441	2	4	296	1	0	0	0	0	0	0	0	1	17474	755	27	1		1	WSCD1	17	5998441	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	4610865	5998441	75196769	145	54885											
GPS2	2874	broad.mit.edu	37	chr17	7216126	7216127	+	Frame_Shift_Ins	INS	-	GG	GG																															gttggatgaaggggagccgaINSgggccaggttggctggtagc																										TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:7216126_7216127insGG	uc002gfv.1	-	10	1195_1196	c.932_933insCC	c.(931-933)CCTfs	p.P311fs	GPS2_uc002gfw.1_Frame_Shift_Ins_p.P273fs|GPS2_uc002gfx.1_Frame_Shift_Ins_p.P311fs|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_Frame_Shift_Ins_p.P311fs	NM_004489	NP_004480	Q13227	GPS2_HUMAN	G protein pathway suppressor 2	311					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			ovary(2)|pancreas(1)	3		Prostate(122;0.157)				AGGGGAGCCGAGGGCCAGGTTG	0.545													---	---	---								GG	7216127	GG	GG	7216126	7	5	296	1	0	1	1	0	0	0	0	0	6772	291	11	0	54	0	GPS2	17	7216126	Frame_Shift_Ins	INS	-	TCGA-H7-7774-01A-21D-2078-08	1217685	7216126	73979084	146	54886											
SPAG5	10615	broad.mit.edu	37	chr17	26913009	26913009	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aacagaccaatgtttctgcaCgccgagactatatggtaaga	14	9	9	9	2	1	3	0	0	1	3	1	4	1	3	2	1	2	3	2	1	5	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:26913009C>T	uc002hbq.2	-	7	1705	c.1613G>A	c.(1612-1614)CGT>CAT	p.R538H	SGK494_uc010waq.1_Intron	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	538					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			central_nervous_system(1)	1	Lung NSC(42;0.00431)					TGTTTCTGCACGCCGAGACTA	0.483													46	143					0	0	0	0	T	26913009	T	T	26913009	3	4	296	1	0	0	0	0	1	0	0	0	15047	536	19	1	2040	1	SPAG5	17	26913009	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	19696883	26913009	54282201	147	54887											
MED24	9862	broad.mit.edu	37	chr17	38175892	38175892	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggctgacaccttcaccagttCcgacacctgccacggacaga	10	6	9	16	2	1	2	1	1	0	1	2	4	2	3	5	2	1	2	5	2	0	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:38175892C>T	uc002htt.2	-	26	3173	c.2860G>A	c.(2860-2862)GAA>AAA	p.E954K	MED24_uc010weq.1_Missense_Mutation_p.E76K|MED24_uc002htr.2_Missense_Mutation_p.E66K|MED24_uc010wer.1_Missense_Mutation_p.E332K|MED24_uc010wes.1_Missense_Mutation_p.E814K|MED24_uc010wet.1_RNA|MED24_uc002hts.2_Missense_Mutation_p.E979K|MED24_uc002htu.2_Missense_Mutation_p.E941K|MED24_uc010cwn.2_Missense_Mutation_p.E941K|MED24_uc010weu.1_Missense_Mutation_p.E864K	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	954					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					TTCACCAGTTCCGACACCTGC	0.657													20	42					0	0	0	0	T	38175892	T	T	38175892	3	4	296	1	0	0	0	0	1	0	0	0	9495	864	30	2	113	2	MED24	17	38175892	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	11262883	38175892	43019318	148	54888											
VEZF1	7716	broad.mit.edu	37	chr17	56060414	56060414	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtcgagaccaacgaagttCggctgctgtccccagcgatg	8	8	13	12	4	0	1	0	0	0	1	3	4	1	1	3	2	3	3	3	2	2	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr17:56060414C>T	uc002ivf.1	-	2	517	c.374G>A	c.(373-375)CGA>CAA	p.R125Q	VEZF1_uc010dcn.1_5'UTR	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	125					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						CAACGAAGTTCGGCTGCTGTC	0.567													10	36					0	0	0	0	T	56060414	T	T	56060414	3	4	296	1	0	0	0	0	1	0	0	0	17223	884	31	1	1211	1	VEZF1	17	56060414	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	17884522	56060414	25134796	149	54889											
ANKRD12	23253	broad.mit.edu	37	chr18	9257777	9257777	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcactttcagatgctgaatcGatttctaaacatatgtcttt	11	17	5	8	1	4	2	2	1	2	1	5	3	4	2	0	0	2	1	0	0	4	5	rs74916798		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr18:9257777G>T	uc002knv.2	+	9	4769	c.4512G>T	c.(4510-4512)TCG>TCT	p.S1504S	ANKRD12_uc002knw.2_Silent_p.S1481S|ANKRD12_uc002knx.2_Silent_p.S1481S|ANKRD12_uc010dkx.1_Silent_p.S1211S	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1504						nucleus				ovary(2)|central_nervous_system(1)	3						ATGCTGAATCGATTTCTAAAC	0.413													11	35					7.03913e-09	7.63566e-09	1	0	T	9257777	T	T	9257777	2	4	296	1	0	0	0	0	0	0	0	1	640	1045	37	3		3	ANKRD12	18	9257777	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08		9257777	68819471	150	54890											
KCTD1	284252	broad.mit.edu	37	chr18	24039710	24039710	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctggaaatacttcttctatCaaggatttgtcaccgcttag	10	15	7	9	1	5	0	2	0	3	0	5	2	5	2	1	2	1	1	1	2	5	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr18:24039710C>G	uc002kvw.2	-	4	1049	c.489G>C	c.(487-489)TTG>TTC	p.L163F	KCTD1_uc010xbj.1_Missense_Mutation_p.L771F|KCTD1_uc010xbk.1_Missense_Mutation_p.L163F|KCTD1_uc002kvy.2_Missense_Mutation_p.L81F	NM_001136205	NP_001129677	Q719H9	KCTD1_HUMAN	potassium channel tetramerisation domain	163					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			ovary(1)	1	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			CTTCTTCTATCAAGGATTTGT	0.512													4	63					0	0	0	0	G	24039710	G	G	24039710	3	3	296	1	0	0	0	0	1	0	0	0	8135	825	29	2	292	2	KCTD1	18	24039710	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	14781933	24039710	54037538	151	54891											
S1PR4	8698	broad.mit.edu	37	chr19	3179595	3179595	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctggggcccactcttcGggctgctgctggccgacgtc	2	10	15	14	3	1	0	0	0	1	0	3	1	1	0	2	4	3	4	2	4	0	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:3179595G>A	uc002lxg.2	+	1	830	c.805G>A	c.(805-807)GGG>AGG	p.G269R		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	269	Helical; Name=6; (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						CCCACTCTTCGGGCTGCTGCT	0.697													31	56					0	0	0	0	A	3179595	A	A	3179595	3	1	296	1	0	0	0	0	1	0	0	0	13861	1116	39	1	807	1	S1PR4	19	3179595	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08		3179595	55949388	152	54892											
ZNF763	284390	broad.mit.edu	37	chr19	12089308	12089308	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccattcaggcattcgaagacGcatggtaatgcacagtgggg	11	8	13	9	2	1	1	1	0	0	1	2	2	1	1	1	4	1	4	1	4	2	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:12089308G>A	uc002msw.2	+	4	724	c.569G>A	c.(568-570)CGC>CAC	p.R190H	ZNF763_uc010xmf.1_Missense_Mutation_p.R210H|ZNF763_uc002msv.2_Missense_Mutation_p.R193H|ZNF763_uc010xmg.1_Missense_Mutation_p.R68H	NM_001012753	NP_001012771	Q0D2J5	ZN763_HUMAN	zinc finger protein 763	190	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						ATTCGAAGACGCATGGTAATG	0.408													40	94					0	0	0	0	A	12089308	A	A	12089308	3	1	296	1	0	0	0	0	1	0	0	0	18204	1087	38	1	592	1	ZNF763	19	12089308	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	8909713	12089308	47039675	153	54893											
UNC13A	23025	broad.mit.edu	37	chr19	17768990	17768990	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actgaggcgttgggttgtgaCgtagtataatagggcggcgg	8	10	18	5	4	0	2	0	2	0	0	0	2	0	2	0	5	0	4	0	5	4	6			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:17768990C>T	uc002nhd.2	-	10	912	c.912G>A	c.(910-912)ACG>ACA	p.T304T		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	216					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						TGGGTTGTGACGTAGTATAAT	0.557													3	31					0	0	0	0	T	17768990	T	T	17768990	2	4	296	1	0	0	0	0	0	0	0	1	17052	523	19	1		1	UNC13A	19	17768990	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	5679682	17768990	41359993	154	54894											
SLC7A10	56301	broad.mit.edu	37	chr19	33702376	33702376	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacatggccgtgaagtaggCaatgttggtgaacgtgtaca	11	9	15	6	2	0	2	0	2	0	0	0	3	0	3	1	4	2	4	1	4	5	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:33702376C>A	uc002num.2	-	6	1003	c.856G>T	c.(856-858)GCC>TCC	p.A286S	SLC7A10_uc002nul.2_5'UTR	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	286	Helical; (Potential).				blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					GTGAAGTAGGCAATGTTGGTG	0.627													5	20					0.000602214	0.000611773	1	0	A	33702376	A	A	33702376	3	1	296	1	0	0	0	0	1	0	0	0	14757	710	25	4	739	4	SLC7A10	19	33702376	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	15933386	33702376	25426607	155	54895											
ZBTB32	27033	broad.mit.edu	37	chr19	36206144	36206148	+	Frame_Shift_Del	DEL	GATGG	-	-																															ctgttggccaaaggggagcaGatgggaagcatggagtgctc																										TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:36206144_36206148delGATGG	uc002oay.2	+	2	826_830	c.616_620delGATGG	c.(616-621)GATGGGfs	p.D206fs	ZBTB32_uc002oaz.2_RNA|MLL4_uc010eei.2_5'Flank	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	206_207					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGGGGAGCAGATGGGAAGCATGGA	0.615													---	---	---								-	36206148	-	-	36206144	7	5	296	1	0	1	0	1	0	0	0	0	17602	942	33	0	618	0	ZBTB32	19	36206144	Frame_Shift_Del	DEL	GATGG	TCGA-H7-7774-01A-21D-2078-08	2503768	36206144	22922839	156	54896											
HKR1	284459	broad.mit.edu	37	chr19	37854366	37854366	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaaagccttttatgtgcaggGagtgtggcagaaggtttcgg	10	11	15	5	1	0	1	0	0	0	1	1	2	0	2	1	4	2	3	1	4	4	3			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:37854366G>A	uc002ogb.2	+	6	1938	c.1669G>A	c.(1669-1671)GAG>AAG	p.E557K	HKR1_uc002ofx.2_Missense_Mutation_p.E273K|HKR1_uc002ofy.2_Missense_Mutation_p.E273K|HKR1_uc002oga.2_Missense_Mutation_p.E539K|HKR1_uc010xto.1_Missense_Mutation_p.E539K|HKR1_uc002ogc.2_Missense_Mutation_p.E538K|HKR1_uc010xtp.1_Missense_Mutation_p.E496K|HKR1_uc002ogd.2_Missense_Mutation_p.E496K	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	557	C2H2-type 10.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATGTGCAGGGAGTGTGGCAG	0.512													9	25					0	0	0	0	A	37854366	A	A	37854366	3	1	296	1	0	0	0	0	1	0	0	0	7233	1175	41	2	1683	2	HKR1	19	37854366	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	1648222	37854366	21274617	157	54897											
ZNF419	79744	broad.mit.edu	37	chr19	58004287	58004287	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgcttctgtaggactgctcaGttcaaacattcagcaacacc	11	11	7	12	0	4	0	3	0	1	0	4	1	4	1	1	1	5	5	1	1	3	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr19:58004287G>A	uc002qov.2	+	5	602	c.362G>A	c.(361-363)AGT>AAT	p.S121N	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Missense_Mutation_p.S122N|ZNF419_uc010etz.1_Missense_Mutation_p.S109N|ZNF419_uc010eua.1_Missense_Mutation_p.S108N|ZNF419_uc002qow.2_Missense_Mutation_p.S89N|ZNF419_uc010eub.1_Missense_Mutation_p.S76N|ZNF419_uc010euc.1_Missense_Mutation_p.S75N	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		GGACTGCTCAGTTCAAACATT	0.473													6	27					0	0	0	0	A	58004287	A	A	58004287	3	1	296	1	0	0	0	0	1	0	0	0	17963	1029	36	4	383	4	ZNF419	19	58004287	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	20149921	58004287	1124696	158	54898											
SLC5A4	6527	broad.mit.edu	37	chr22	32625325	32625325	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgaccgaaagcatcaggcctCgcagtcctggagccgggaaa	11	5	13	12	3	1	1	1	1	0	0	3	4	2	3	4	3	2	2	4	3	2	0	rs142416109		TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr22:32625325C>T	uc003ami.2	-	11	1138	c.1136G>A	c.(1135-1137)CGA>CAA	p.R379Q		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	379	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CATCAGGCCTCGCAGTCCTGG	0.537													5	36					0	0	0	0	T	32625325	T	T	32625325	3	4	296	1	0	0	0	0	1	0	0	0	14731	884	31	1	863	1	SLC5A4	22	32625325	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08		32625325	18679241	159	54899											
APOL2	23780	broad.mit.edu	37	chr22	36623928	36623928	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggtccaagttgcgggcttggGctcgtgcccgcaatttgttt	4	13	14	10	3	0	0	0	0	0	0	2	0	1	0	2	3	2	5	2	3	2	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr22:36623928G>A	uc003aoz.2	-	5	872	c.536C>T	c.(535-537)GCC>GTC	p.A179V	APOL2_uc011amm.1_Missense_Mutation_p.A291V|APOL2_uc003apa.2_Missense_Mutation_p.A179V	NM_030882	NP_112092	Q9BQE5	APOL2_HUMAN	apolipoprotein L2	179					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding				0						GCGGGCTTGGGCTCGTGCCCG	0.517													16	37					0	0	0	0	A	36623928	A	A	36623928	3	1	296	1	0	0	0	0	1	0	0	0	806	1203	42	4	481	4	APOL2	22	36623928	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	3998603	36623928	14680638	160	54900											
EP300	2033	broad.mit.edu	37	chr22	41564866	41564866	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctgactgccctccacccaaCcagaggtatgactagctcac	10	8	7	16	0	2	3	1	2	1	1	3	3	3	3	4	1	3	2	4	1	3	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chr22:41564866C>G	uc003azl.3	+	25	4562	c.4167C>G	c.(4165-4167)AAC>AAG	p.N1389K		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1389					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CTCCACCCAACCAGAGGTATG	0.458			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				5	80					0	0	0	0	G	41564866	G	G	41564866	3	3	296	1	0	0	0	0	1	0	0	0	5172	506	18	4	4265	4	EP300	22	41564866	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	4940938	41564866	9739700	161	54901											
POLA1	5422	broad.mit.edu	37	chrX	24722565	24722565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatgaccttgaagatgatGcccttgatgctgatgagaaa	13	11	11	6	0	0	8	0	7	0	2	0	9	0	8	2	0	2	1	2	0	2	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:24722565G>A	uc004dbl.2	+	4	330	c.307G>A	c.(307-309)GCC>ACC	p.A103T	POLA1_uc004dbm.2_Missense_Mutation_p.A109T|POLA1_uc004dbn.2_5'UTR	NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	103	Asp-rich.				cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	TGAAGATGATGCCCTTGATGC	0.368													8	216					0	0	0	0	A	24722565	A	A	24722565	3	1	296	1	0	0	0	0	1	0	0	0	12242	1319	46	4	321	4	POLA1	23	24722565	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08		24722565	130547995	162	54902											
MAGEB3	4114	broad.mit.edu	37	chrX	30254629	30254629	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	gggacagtgactcgtgggagGggatttcccaagacaggtct	9	8	16	8	1	1	2	0	1	1	1	3	5	2	5	1	5	0	0	1	5	1	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:30254629G>T	uc004dca.1	+	5	1325	c.588G>T	c.(586-588)AGG>AGT	p.R196S		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	196	MAGE.										0						CTCGTGGGAGGGGATTTCCCA	0.468													12	35					6.40141e-05	6.67973e-05	1	0	T	30254629	T	T	30254629	3	4	296	1	0	0	0	0	1	0	0	0	9230	1223	43	4	590	4	MAGEB3	23	30254629	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	5532064	30254629	125015931	163	54903											
FAM47A	158724	broad.mit.edu	37	chrX	34149053	34149053	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttccttagttttcttcaccCgggcctcacaacgatcccat	7	13	6	15	2	3	0	2	0	1	0	5	1	5	0	4	1	1	2	4	1	2	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:34149053C>T	uc004ddg.2	-	1	1376	c.1343G>A	c.(1342-1344)CGG>CAG	p.R448Q		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	448										ovary(4)|central_nervous_system(1)	5						TTTCTTCACCCGGGCCTCACA	0.562													7	59					0	0	0	0	T	34149053	T	T	34149053	3	4	296	1	0	0	0	0	1	0	0	0	5601	652	23	1	1036	1	FAM47A	23	34149053	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	3894424	34149053	121121507	164	54904											
USP9X	8239	broad.mit.edu	37	chrX	41075168	41075168	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttaggttgataccgtaaagcGcttgctgattaaaaaattac	14	13	8	6	2	0	2	0	2	0	0	0	2	0	2	1	1	4	4	1	1	8	7			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:41075168G>A	uc004dfb.2	+	35	5981	c.5348G>A	c.(5347-5349)CGC>CAC	p.R1783H	USP9X_uc004dfc.2_Missense_Mutation_p.R1783H	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1783					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						ACCGTAAAGCGCTTGCTGATT	0.318													4	46					0	0	0	0	A	41075168	A	A	41075168	3	1	296	1	0	0	0	0	1	0	0	0	17158	1087	38	1	5482	1	USP9X	23	41075168	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	6926115	41075168	114195392	165	54905											
PPP1R3F	89801	broad.mit.edu	37	chrX	49127007	49127007	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatccggggctcggcctgggTcccggccaggcatccgcctc	3	6	15	17	4	0	0	0	0	0	0	5	1	3	0	6	6	0	2	6	6	0	0			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:49127007T>A	uc004dnh.1	+	1	691	c.675T>A	c.(673-675)GGT>GGA	p.G225G	PPP1R3F_uc011mnd.1_Intron|PPP1R3F_uc004dni.2_Intron	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	225	CBM21.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					TCGGCCTGGGTCCCGGCCAGG	0.751													7	13					0	0	0	0	A	49127007	A	A	49127007	2	1	296	1	0	0	0	0	0	0	0	1	12435	1654	58	5		5	PPP1R3F	23	49127007	Silent	SNP	T	TCGA-H7-7774-01A-21D-2078-08	8051839	49127007	106143553	166	54906											
IQSEC2	23096	broad.mit.edu	37	chrX	53279948	53279948	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgagcggtcactcaggtccaCggagctgtcactaggaggct	8	8	14	11	2	3	1	3	1	0	0	4	3	4	3	1	5	2	2	1	5	1	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:53279948C>T	uc004dsd.2	-	5	2011	c.1810G>A	c.(1810-1812)GTG>ATG	p.V604M	IQSEC2_uc004dsc.2_Missense_Mutation_p.V399M	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	594	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						CTCAGGTCCACGGAGCTGTCA	0.657													7	11					0	0	0	0	T	53279948	T	T	53279948	3	4	296	1	0	0	0	0	1	0	0	0	7857	536	19	1	2700	1	IQSEC2	23	53279948	Missense_Mutation	SNP	C	TCGA-H7-7774-01A-21D-2078-08	4152941	53279948	101990612	167	54907											
HUWE1	10075	broad.mit.edu	37	chrX	53577938	53577938	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcatgcatgagctgtcgctgCcgggcttcttgctctcgtct	3	14	11	13	3	4	1	1	1	3	0	6	1	4	1	1	1	4	5	1	1	0	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:53577938C>A	uc004dsp.2	-	65	9711	c.9309G>T	c.(9307-9309)CGG>CGT	p.R3103R	HUWE1_uc004dsn.2_Silent_p.R1911R	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3103					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GCTGTCGCTGCCGGGCTTCTT	0.582													12	41					1.08611e-07	1.16499e-07	1	0	A	53577938	A	A	53577938	2	1	296	1	0	0	0	0	0	0	0	1	7500	726	26	4		4	HUWE1	23	53577938	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	297990	53577938	101692622	168	54908											
ARL13A	392509	broad.mit.edu	37	chrX	100240718	100240718	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ctacacttttgttagatgagTatgaactttccatctatgac	11	16	6	8	0	1	4	0	3	1	1	2	4	2	4	1	0	2	2	1	0	5	7			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:100240718T>C	uc004ego.2	+	4	309	c.193T>C	c.(193-195)TAT>CAT	p.Y65H	ARL13A_uc011mrf.1_Missense_Mutation_p.Y65H|ARL13A_uc010nng.2_Missense_Mutation_p.Y65H	NM_001012990	NP_001013008	Q5H913	AR13A_HUMAN	ADP-ribosylation factor-like 13 isoform a	65							GTP binding			ovary(1)	1						GTTAGATGAGTATGAACTTTC	0.463													3	47					0	0	0	0	C	100240718	C	C	100240718	3	2	296	1	0	0	0	0	1	0	0	0	928	1638	57	5	203	5	ARL13A	23	100240718	Missense_Mutation	SNP	T	TCGA-H7-7774-01A-21D-2078-08	46662780	100240718	55029842	169	54909											
NKAP	79576	broad.mit.edu	37	chrX	119059238	119059238	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatttctcgaaaactggccAgaatcttgttctctctcttt	8	16	5	12	1	4	1	0	0	4	1	7	2	4	1	2	1	1	1	2	1	3	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:119059238A>G	uc004esh.2	-	9	1360	c.1193T>C	c.(1192-1194)CTG>CCG	p.L398P	NKAP_uc004esg.2_Missense_Mutation_p.L285P	NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	398	Necessary for interaction with HDAC3 and transcriptional repression.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						AAAACTGGCCAGAATCTTGTT	0.398													29	82					0	0	0	0	G	119059238	G	G	119059238	3	3	296	1	0	0	0	0	1	0	0	0	10493	188	7	5	58	5	NKAP	23	119059238	Missense_Mutation	SNP	A	TCGA-H7-7774-01A-21D-2078-08	18818520	119059238	36211322	170	54910											
STAG2	10735	broad.mit.edu	37	chrX	123196817	123196817	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaatcactgagctttttgcCgtggcccttcctcagttatt	8	15	7	11	1	2	1	2	1	0	0	3	1	3	1	3	1	2	2	3	1	3	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:123196817C>A	uc004etz.3	+	17	2043	c.1704C>A	c.(1702-1704)GCC>GCA	p.A568A	STAG2_uc004eua.2_Silent_p.A568A|STAG2_uc004eub.2_Silent_p.A568A|STAG2_uc004euc.2_Silent_p.A568A|STAG2_uc004eud.2_Silent_p.A568A|STAG2_uc004eue.2_Silent_p.A568A	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	568					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						AGCTTTTTGCCGTGGCCCTTC	0.358													16	44					1.67942e-08	1.8115e-08	1	0	A	123196817	A	A	123196817	2	1	296	1	0	0	0	0	0	0	0	1	15309	639	23	3		3	STAG2	23	123196817	Silent	SNP	C	TCGA-H7-7774-01A-21D-2078-08	4137579	123196817	32073743	171	54911											
ARHGAP36	158763	broad.mit.edu	37	chrX	130217855	130217855	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgtcggggaaacgtggtgcGaagggtgtttggccgcatcc	6	9	17	9	5	0	0	0	0	0	0	3	2	1	1	2	5	2	2	2	5	2	1			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:130217855G>A	uc004evz.2	+	4	812	c.467G>A	c.(466-468)CGA>CAA	p.R156Q	ARHGAP36_uc004ewa.2_Missense_Mutation_p.R144Q|ARHGAP36_uc004ewb.2_Missense_Mutation_p.R125Q|ARHGAP36_uc004ewc.2_Missense_Mutation_p.R20Q	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	156	Arg-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						AACGTGGTGCGAAGGGTGTTT	0.617													27	53					0	0	0	0	A	130217855	A	A	130217855	3	1	296	1	0	0	0	0	1	0	0	0	883	1058	37	1	477	1	ARHGAP36	23	130217855	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	7021038	130217855	25052705	172	54912											
MMGT1	93380	broad.mit.edu	37	chrX	135047295	135047295	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaagtactcgaccacgaTgattaaatacataaaaggat	19	8	8	6	2	0	1	0	1	0	0	1	5	0	3	1	2	2	1	1	2	8	4			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:135047295T>C	uc004ezi.1	-	4	584	c.284A>G	c.(283-285)CAT>CGT	p.H95R	MMGT1_uc011mvw.1_Missense_Mutation_p.H160R	NM_173470	NP_775741	Q8N4V1	MMGT1_HUMAN	membrane magnesium transporter 1 precursor	95	Cytoplasmic (Potential).					early endosome membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	magnesium ion transmembrane transporter activity				0						TCGACCACGATGATTAAATAC	0.353													42	100					0	0	0	0	C	135047295	C	C	135047295	3	2	296	1	0	0	0	0	1	0	0	0	9700	1464	51	5	115	5	MMGT1	23	135047295	Missense_Mutation	SNP	T	TCGA-H7-7774-01A-21D-2078-08	4829440	135047295	20223265	173	54913											
MAP7D3	79649	broad.mit.edu	37	chrX	135313731	135313731	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cgtctctcgcttttgccttgGgagatgcttccatgcttgct	3	16	10	12	2	1	1	0	0	1	1	4	2	2	1	2	1	4	4	2	1	0	5			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:135313731G>A	uc004ezt.2	-	8	1476	c.1385C>T	c.(1384-1386)CCC>CTC	p.P462L	MAP7D3_uc004ezs.2_Missense_Mutation_p.P426L|MAP7D3_uc011mwc.1_Missense_Mutation_p.P444L|MAP7D3_uc010nsa.1_Missense_Mutation_p.P420L	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	462						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					TTTTGCCTTGGGAGATGCTTC	0.448													34	90					0	0	0	0	A	135313731	A	A	135313731	3	1	296	1	0	0	0	0	1	0	0	0	9322	1232	43	4	1289	4	MAP7D3	23	135313731	Missense_Mutation	SNP	G	TCGA-H7-7774-01A-21D-2078-08	266436	135313731	19956829	174	54914											
FGF13	2258	broad.mit.edu	37	chrX	137715119	137715119	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgggagaactccgtgagatcGtgcagtgatggctccttgta	8	10	14	9	3	0	3	0	2	0	2	3	5	2	3	2	2	2	3	2	2	2	2			TCGA-H7-7774-01A-21D-2078-08	TCGA-H7-7774-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	0eb5b79a-e3be-4b19-aef6-74247986aaf6	14396841-202f-433a-bdcc-292b733f535f	g.chrX:137715119G>A	uc004fam.2	-	5	1292	c.630C>T	c.(628-630)CAC>CAT	p.H210H	FGF13_uc004fan.2_Silent_p.H157H|FGF13_uc011mwi.1_Silent_p.H191H|FGF13_uc004faq.2_Silent_p.H220H|FGF13_uc004far.2_Silent_p.H191H|FGF13_uc011mwj.1_Silent_p.H220H|FGF13_uc011mwk.1_Silent_p.H164H	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	210					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CCGTGAGATCGTGCAGTGATG	0.463													7	72					0	0	0	0	A	137715119	A	A	137715119	2	1	296	1	0	0	0	0	0	0	0	1	5874	1136	40	1		1	FGF13	23	137715119	Silent	SNP	G	TCGA-H7-7774-01A-21D-2078-08	2401388	137715119	17555441	175	54915											
PLA2G2D	26279	broad.mit.edu	37	chr1	20440744	20440744	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctgctgctcacaccagcttcCcttgtcagctgtggacggag	6	10	11	14	1	2	0	2	0	0	0	3	2	3	2	2	2	4	4	2	2	0	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:20440744C>G	uc001bcz.2	-	4	318	c.301G>C	c.(301-303)GGA>CGA	p.G101R	PLA2G2D_uc009vpo.2_RNA	NM_012400	NP_036532	Q9UNK4	PA2GD_HUMAN	phospholipase A2, group IID precursor	101					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity				0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000798)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CACCAGCTTCCCTTGTCAGCT	0.557										Multiple Myeloma(11;0.12)			13	37					0	0	0	0	G	20440744	G	G	20440744	3	3	297	1	0	0	0	0	1	0	0	0	12052	632	22	4	140	4	PLA2G2D	1	20440744	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		20440744	228809877	1	54916											
HSPG2	3339	broad.mit.edu	37	chr1	22178186	22178186	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cggatgggctgggtgctgccGgcagctgagggataagatgg	7	7	20	7	2	0	2	0	1	0	1	0	4	0	4	1	6	3	4	1	6	1	1	rs150649767		TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:22178186G>A	uc001bfj.2	-	55	7051	c.7011C>T	c.(7009-7011)GCC>GCT	p.A2337A	HSPG2_uc009vqd.2_Silent_p.A2338A	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2337	Ig-like C2-type 8.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGGTGCTGCCGGCAGCTGAGG	0.652													31	78					0	0	0	0	A	22178186	A	A	22178186	2	1	297	1	0	0	0	0	0	0	0	1	7469	1103	39	1		1	HSPG2	1	22178186	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	1737442	22178186	227072435	2	54917											
C1QC	714	broad.mit.edu	37	chr1	22974125	22974125	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtcaccttctgtggccacaCgtccaaaaccaatcaggtca	11	8	8	14	1	4	0	3	0	1	0	5	0	5	0	4	3	1	0	4	3	3	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:22974125C>T	uc001bgc.3	+	3	690	c.587C>T	c.(586-588)ACG>ATG	p.T196M	C1QC_uc001bga.3_Missense_Mutation_p.T196M|C1QC_uc001bgb.2_Missense_Mutation_p.T196M	NM_172369	NP_758957	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	196	C1q.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen					0		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TGTGGCCACACGTCCAAAACC	0.597													24	73					0	0	0	0	T	22974125	T	T	22974125	3	4	297	1	0	0	0	0	1	0	0	0	1966	536	19	1	593	1	C1QC	1	22974125	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	795939	22974125	226276496	3	54918											
MYOM3	127294	broad.mit.edu	37	chr1	24434494	24434494	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctgactcaccaagacagctcGgaggaggccgtcagagccag	11	4	13	13	2	2	3	2	1	0	2	3	5	2	5	3	3	2	1	3	3	1	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:24434494G>A	uc001bin.3	-	3	394	c.231C>T	c.(229-231)TCC>TCT	p.S77S	MYOM3_uc001bio.2_Silent_p.S77S|MYOM3_uc001bip.1_5'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	77										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		AAGACAGCTCGGAGGAGGCCG	0.642													15	43					0	0	0	0	A	24434494	A	A	24434494	2	1	297	1	0	0	0	0	0	0	0	1	10146	1103	39	1		1	MYOM3	1	24434494	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	1460369	24434494	224816127	4	54919											
C1orf172	126695	broad.mit.edu	37	chr1	27276605	27276605	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gcccccgacgagtctgtgtcGgtgccctggaaggatgagtc	6	8	15	12	3	1	1	0	1	1	0	3	5	1	3	3	3	1	0	3	3	1	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:27276605G>A	uc001bni.1	-	4	1241	c.1152C>T	c.(1150-1152)ACC>ACT	p.T384T		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	384										large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		AGTCTGTGTCGGTGCCCTGGA	0.597													14	37					0	0	0	0	A	27276605	A	A	27276605	2	1	297	1	0	0	0	0	0	0	0	1	2022	1103	39	1		1	C1orf172	1	27276605	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	2842111	27276605	221974016	5	54920											
HIVEP3	59269	broad.mit.edu	37	chr1	41979227	41979227	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgaggagtctgcccgcagtgCatgtggtgggccaggcgggg	5	7	20	9	2	1	1	0	1	1	0	1	2	1	2	2	6	2	2	2	6	0	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:41979227C>T	uc001cgz.3	-	8	6878	c.5665G>A	c.(5665-5667)GCA>ACA	p.A1889T	HIVEP3_uc001cha.3_Missense_Mutation_p.A1889T|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1889					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GCCCGCAGTGCATGTGGTGGG	0.657													9	27					0	0	0	0	T	41979227	T	T	41979227	3	4	297	1	0	0	0	0	1	0	0	0	7227	710	25	4	1563	4	HIVEP3	1	41979227	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	14702622	41979227	207271394	6	54921											
CCDC24	149473	broad.mit.edu	37	chr1	44461731	44461731	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctaccttcgacctcgaggcCagtcggctacccaccgctgg	6	7	10	18	4	0	0	0	0	0	0	3	2	0	0	6	3	2	2	6	3	2	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:44461731C>G	uc001clj.2	+	9	994	c.823C>G	c.(823-825)CAG>GAG	p.Q275E	SLC6A9_uc009vxe.2_Intron|SLC6A9_uc010okm.1_Intron|CCDC24_uc001clk.2_Silent_p.A228A|CCDC24_uc009vxc.2_Missense_Mutation_p.Q239E	NM_152499	NP_689712	Q8N4L8	CCD24_HUMAN	coiled-coil domain containing 24	275											0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				ACCTCGAGGCCAGTCGGCTAC	0.682													22	51					0	0	0	0	G	44461731	G	G	44461731	3	3	297	1	0	0	0	0	1	0	0	0	2812	595	21	4	853	4	CCDC24	1	44461731	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	2482504	44461731	204788890	7	54922											
OSBPL9	114883	broad.mit.edu	37	chr1	52249590	52249590	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaaaatttctattcagtttCagccttttatgctgagtgtt	9	19	7	6	0	3	2	2	2	1	0	3	2	3	2	1	0	2	3	1	0	4	7			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:52249590C>T	uc001cst.2	+	18	1536	c.1517C>T	c.(1516-1518)TCA>TTA	p.S506L	OSBPL9_uc001css.2_Missense_Mutation_p.S511L|OSBPL9_uc001csx.2_RNA|OSBPL9_uc009vza.2_Missense_Mutation_p.S507L|OSBPL9_uc001csu.2_Missense_Mutation_p.S516L|OSBPL9_uc001csv.2_Missense_Mutation_p.S341L|OSBPL9_uc001csw.2_Missense_Mutation_p.S493L|OSBPL9_uc001csy.2_Missense_Mutation_p.S328L|OSBPL9_uc001csz.2_Missense_Mutation_p.S328L|OSBPL9_uc001cta.2_Missense_Mutation_p.S396L|OSBPL9_uc001ctb.2_Missense_Mutation_p.S291L	NM_024586	NP_078862	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9 isoform e	506					lipid transport		lipid binding			central_nervous_system(1)	1						TATTCAGTTTCAGCCTTTTAT	0.363													15	25					0	0	0	0	T	52249590	T	T	52249590	3	4	297	1	0	0	0	0	1	0	0	0	11338	838	29	2	1691	2	OSBPL9	1	52249590	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	7787859	52249590	197001031	8	54923											
C1orf175	374977	broad.mit.edu	37	chr1	55167769	55167769	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggtcttccccaggcacgaGaggtcgtgcgctcctcctgc	4	10	12	15	3	1	1	0	0	1	1	5	2	4	1	4	3	2	2	4	3	0	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:55167769G>C	uc010ooe.1	+	20	3616	c.3292G>C	c.(3292-3294)GAG>CAG	p.E1098Q	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.E616Q|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Missense_Mutation_p.E300Q	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	1098	HEAT 3.					integral to membrane	binding				0						CCAGGCACGAGAGGTCGTGCG	0.607													14	30					0	0	0	0	C	55167769	C	C	55167769	3	2	297	1	0	0	0	0	1	0	0	0	2025	943	33	2	3362	2	C1orf175	1	55167769	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	2918179	55167769	194082852	9	54924											
PDE4B	5142	broad.mit.edu	37	chr1	66723334	66723334	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tttctcttttcaccagacacGgcgatgacttgattgtaact	9	15	7	10	2	2	3	1	2	1	1	3	4	2	3	1	1	1	1	1	1	1	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:66723334G>A	uc001dcn.2	+	5	672	c.481G>A	c.(481-483)GGC>AGC	p.G161S	PDE4B_uc009war.2_Missense_Mutation_p.G69S|PDE4B_uc001dco.2_Missense_Mutation_p.G161S|PDE4B_uc001dcp.2_Missense_Mutation_p.G146S	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	161					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	CACCAGACACGGCGATGACTT	0.368													46	124					0	0	0	0	A	66723334	A	A	66723334	3	1	297	1	0	0	0	0	1	0	0	0	11694	1116	39	1	735	1	PDE4B	1	66723334	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	11555565	66723334	182527287	10	54925											
FAM73A	374986	broad.mit.edu	37	chr1	78340631	78340631	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcatgcagttactcattcGccgcactgagcttttaatgg	8	13	8	12	2	2	1	2	1	0	0	3	1	2	1	2	1	3	4	2	1	2	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:78340631G>A	uc001dhx.2	+	16	1813	c.1781G>A	c.(1780-1782)CGC>CAC	p.R594H	FAM73A_uc010ork.1_Missense_Mutation_p.R595H|FAM73A_uc010orl.1_Missense_Mutation_p.R557H	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	594						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		TTACTCATTCGCCGCACTGAG	0.423													11	36					0	0	0	0	A	78340631	A	A	78340631	3	1	297	1	0	0	0	0	1	0	0	0	5649	1087	38	1	1843	1	FAM73A	1	78340631	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	11617297	78340631	170909990	11	54926											
GBP4	115361	broad.mit.edu	37	chr1	89651007	89651007	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccaggtagagtgacaatcAttatgttgctagccatgtca	11	11	9	10	0	2	2	2	1	0	1	2	2	2	2	3	1	2	3	3	1	4	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:89651007A>G	uc001dnb.2	-	11	1969	c.1853T>C	c.(1852-1854)ATG>ACG	p.M618T		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	618						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		AGTGACAATCATTATGTTGCT	0.353													9	42					0	0	0	0	G	89651007	G	G	89651007	3	3	297	1	0	0	0	0	1	0	0	0	6311	217	8	5	73	5	GBP4	1	89651007	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	11310376	89651007	159599614	12	54927											
CELSR2	1952	broad.mit.edu	37	chr1	109793107	109793109	+	In_Frame_Del	DEL	CCG	-	-																															tcacactgcccgaggagcacCcgtgcttaaaggctccacgg																										TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:109793107_109793109delCCG	uc001dxa.3	+	1	467_469	c.406_408delCCG	c.(406-408)CCGdel	p.P136del		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	136	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CGAGGAGCACCCGTGCTTAAAGG	0.66													---	---	---								-	109793109	-	-	109793107	7	5	297	1	0	1	0	1	0	0	0	0	3237	623	22	0	408	0	CELSR2	1	109793107	In_Frame_Del	DEL	CCG	TCGA-HD-7229-01A-11D-2012-08	20142100	109793107	139457514	13	54928											
C1orf114	57821	broad.mit.edu	37	chr1	169390628	169390628	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttcagtttttctctcttttcTtctagttgtttttgtagttc	3	26	5	7	0	5	0	1	0	4	0	7	0	5	0	0	0	0	5	0	0	2	12			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:169390628T>C	uc001gga.1	-	3	1209	c.1041A>G	c.(1039-1041)GAA>GAG	p.E347E	C1orf114_uc001gfz.1_Silent_p.E347E|C1orf114_uc009wvq.1_Silent_p.E347E|C1orf114_uc001ggb.2_Silent_p.E347E|C1orf114_uc001ggc.1_Silent_p.E347E	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	347	Potential.										0	all_hematologic(923;0.208)					CTCTCTTTTCTTCTAGTTGTT	0.353													14	41					0	0	0	0	C	169390628	C	C	169390628	2	2	297	1	0	0	0	0	0	0	0	1	1996	1606	56	5		5	C1orf114	1	169390628	Silent	SNP	T	TCGA-HD-7229-01A-11D-2012-08	59597521	169390628	79859993	14	54929											
NAV1	89796	broad.mit.edu	37	chr1	201750276	201750276	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acctgggacttctaagtggcGgagggagcggcctgagagct	8	7	17	9	2	1	1	0	1	1	1	1	5	1	4	2	5	2	1	2	5	1	2	rs143487790		TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:201750276G>A	uc001gwu.2	+	5	1849	c.1502G>A	c.(1501-1503)CGG>CAG	p.R501Q	NAV1_uc001gwv.1_Missense_Mutation_p.R9Q|NAV1_uc001gww.1_Missense_Mutation_p.R110Q|NAV1_uc001gwx.2_Missense_Mutation_p.R110Q|NAV1_uc001gwy.1_5'Flank	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	501					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						TCTAAGTGGCGGAGGGAGCGG	0.542													31	69					0	0	0	0	A	201750276	A	A	201750276	3	1	297	1	0	0	0	0	1	0	0	0	10236	1116	39	1	1577	1	NAV1	1	201750276	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	32359648	201750276	47500345	15	54930											
ESRRG	2104	broad.mit.edu	37	chr1	216680338	216680338	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcattgggactttgccttcTagtttgatgttgtagaaatg	8	17	11	5	0	1	2	0	1	1	1	1	3	1	3	1	1	2	4	1	1	3	7			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:216680338T>C	uc001hkw.1	-	7	1486	c.1320A>G	c.(1318-1320)CTA>CTG	p.L440L	ESRRG_uc001hky.1_Silent_p.L417L|ESRRG_uc009xdp.1_Silent_p.L417L|ESRRG_uc001hkz.1_Silent_p.L378L|ESRRG_uc010puc.1_Silent_p.L417L|ESRRG_uc001hla.1_Silent_p.L417L|ESRRG_uc001hlb.1_Silent_p.L417L|ESRRG_uc010pud.1_Silent_p.L248L|ESRRG_uc001hlc.1_Silent_p.L417L|ESRRG_uc001hld.1_Silent_p.L417L|ESRRG_uc001hkx.1_Silent_p.L452L|ESRRG_uc009xdo.1_Silent_p.L417L	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	440					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CTTTGCCTTCTAGTTTGATGT	0.493													11	56					0	0	0	0	C	216680338	C	C	216680338	2	2	297	1	0	0	0	0	0	0	0	1	5286	1509	53	5		5	ESRRG	1	216680338	Silent	SNP	T	TCGA-HD-7229-01A-11D-2012-08	14930062	216680338	32570283	16	54931											
C1orf65	164127	broad.mit.edu	37	chr1	223567884	223567884	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accagaggaccaggagagccCgcgccaggagaagctggaga	13	1	16	11	2	0	4	0	0	0	4	0	8	0	5	4	4	2	1	4	4	1	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:223567884C>T	uc001hoa.2	+	1	1170	c.1067C>T	c.(1066-1068)CCG>CTG	p.P356L		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	356										central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		CAGGAGAGCCCGCGCCAGGAG	0.687													6	11					0	0	0	0	T	223567884	T	T	223567884	3	4	297	1	0	0	0	0	1	0	0	0	2065	652	23	1	1069	1	C1orf65	1	223567884	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	6887546	223567884	25682737	17	54932											
PLD5	200150	broad.mit.edu	37	chr1	242287898	242287898	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaattttaatgaactatataGagcaaatatcctttgtaaat	17	15	5	4	0	0	2	0	1	0	1	1	3	1	2	1	0	2	2	1	0	10	8			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr1:242287898G>C	uc001hzn.1	-	6	932	c.805C>G	c.(805-807)CTA>GTA	p.L269V	PLD5_uc001hzl.3_Missense_Mutation_p.L207V|PLD5_uc001hzm.3_Missense_Mutation_p.L59V|PLD5_uc001hzo.1_Missense_Mutation_p.L177V			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	269						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			GAACTATATAGAGCAAATATC	0.368													7	25					0	0	0	0	C	242287898	C	C	242287898	3	2	297	1	0	0	0	0	1	0	0	0	12104	933	33	2	825	2	PLD5	1	242287898	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	18720014	242287898	6962723	18	54933											
DNAJC5G	285126	broad.mit.edu	37	chr2	27499677	27499677	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgctggatcttaagaagggCgcctcacctgaagacttcaa	11	9	11	10	1	3	3	2	1	1	2	3	4	3	4	2	2	1	1	2	2	4	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr2:27499677C>A	uc002rjl.1	+	3	499	c.81C>A	c.(79-81)GGC>GGA	p.G27G	SLC30A3_uc010ylh.1_5'Flank|DNAJC5G_uc010yli.1_Silent_p.G27G|DNAJC5G_uc002rjm.1_Silent_p.G27G	NM_173650	NP_775921	Q8N7S2	DNJ5G_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	27	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTAAGAAGGGCGCCTCACCTG	0.463													20	21					1.01871e-10	1.88592e-10	1	0	A	27499677	A	A	27499677	2	1	297	1	0	0	0	0	0	0	0	1	4674	755	27	3		3	DNAJC5G	2	27499677	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08		27499677	215699696	19	54934											
PRKCE	5581	broad.mit.edu	37	chr2	46378288	46378288	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgaggccgacaatgaggacGacctatttgagtccatcctc	10	10	10	11	2	0	3	0	3	0	0	3	6	2	4	4	2	0	0	4	2	2	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr2:46378288G>T	uc002rut.2	+	13	2037	c.1840G>T	c.(1840-1842)GAC>TAC	p.D614Y		NM_005400	NP_005391	Q02156	KPCE_HUMAN	protein kinase C, epsilon	614	Protein kinase.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity			lung(4)|ovary(3)|kidney(1)|breast(1)|large_intestine(1)	10		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			CAATGAGGACGACCTATTTGA	0.587													10	36					3.86212e-05	6.76808e-05	1	0	T	46378288	T	T	46378288	3	4	297	1	0	0	0	0	1	0	0	0	12573	1058	37	3	1890	3	PRKCE	2	46378288	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	18878611	46378288	196821085	20	54935											
LRRTM4	80059	broad.mit.edu	37	chr2	77745481	77745481	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagagatggtatatgtgcagGgcccagatccattaaccgat	12	9	11	9	1	0	2	0	0	0	2	1	4	1	2	3	2	2	2	3	2	3	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr2:77745481G>T	uc002snr.2	-	3	1929	c.1514C>A	c.(1513-1515)CCC>CAC	p.P505H	LRRTM4_uc002snq.2_Missense_Mutation_p.P505H|LRRTM4_uc002sns.2_Missense_Mutation_p.P505H|LRRTM4_uc002snt.2_Missense_Mutation_p.P506H	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	505	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		ATATGTGCAGGGCCCAGATCC	0.443													12	23					2.80697e-09	5.14374e-09	1	0	T	77745481	T	T	77745481	3	4	297	1	0	0	0	0	1	0	0	0	9092	1232	43	4	272	4	LRRTM4	2	77745481	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	31367193	77745481	165453892	21	54936											
LRP1B	53353	broad.mit.edu	37	chr2	141294273	141294273	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ataagcgttgcaggaggaatTtttagctgcaagaaaaaaaa	18	9	10	4	1	0	1	0	0	0	1	0	3	0	3	0	2	4	4	0	2	8	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr2:141294273T>C	uc002tvj.1	-	46	8491	c.7519A>G	c.(7519-7521)AAT>GAT	p.N2507D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2507	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGGAGGAATTTTTAGCTGCA	0.318										TSP Lung(27;0.18)			5	33					0	0	0	0	C	141294273	C	C	141294273	3	2	297	1	0	0	0	0	1	0	0	0	9005	1841	64	5	6464	5	LRP1B	2	141294273	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08	63548792	141294273	101905100	22	54937											
LRP1B	53353	broad.mit.edu	37	chr2	141571249	141571249	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgatggttagggctgtagctTttgttaattcttctttcatt	6	21	9	5	0	3	1	1	1	2	0	3	1	3	1	0	2	1	5	0	2	3	9			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr2:141571249T>G	uc002tvj.1	-	32	6308	c.5336A>C	c.(5335-5337)AAA>ACA	p.K1779T		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1779	Extracellular (Potential).|LDL-receptor class B 17.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGCTGTAGCTTTTGTTAATTC	0.358										TSP Lung(27;0.18)			22	35					0	0	0	0	G	141571249	G	G	141571249	3	3	297	1	0	0	0	0	1	0	0	0	9005	1841	64	5	8703	5	LRP1B	2	141571249	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08	276976	141571249	101628124	23	54938											
XIRP2	129446	broad.mit.edu	37	chr2	168102128	168102128	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcacataatattatgcccaGtattgaccatatacaaggtg	15	12	6	8	0	1	1	1	1	0	0	1	1	1	1	2	1	2	1	2	1	7	7			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr2:168102128G>A	uc002udx.2	+	8	4244	c.4226G>A	c.(4225-4227)AGT>AAT	p.S1409N	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.S1234N|XIRP2_uc010fpq.2_Missense_Mutation_p.S1187N|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1234					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATTATGCCCAGTATTGACCAT	0.343													5	36					0	0	0	0	A	168102128	A	A	168102128	3	1	297	1	0	0	0	0	1	0	0	0	17498	1029	36	4	4256	4	XIRP2	2	168102128	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	26530879	168102128	75097245	24	54939											
ABI2	10152	broad.mit.edu	37	chr2	204291988	204291988	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgtcatcaagaagaatgaCgatggttggtatgagggagt	13	11	14	3	1	2	4	2	2	0	2	2	6	2	5	0	3	0	2	0	3	5	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr2:204291988C>G	uc002vaa.2	+	11	1690	c.1455C>G	c.(1453-1455)GAC>GAG	p.D485E	ABI2_uc002uzz.2_Missense_Mutation_p.D447E|ABI2_uc010zih.1_Missense_Mutation_p.D133E|ABI2_uc010zii.1_Missense_Mutation_p.D479E|ABI2_uc010zij.1_Missense_Mutation_p.D362E|ABI2_uc002vab.2_Missense_Mutation_p.D373E|ABI2_uc010zik.1_Missense_Mutation_p.D210E|ABI2_uc010zil.1_Missense_Mutation_p.D349E|ABI2_uc010zim.1_Missense_Mutation_p.D298E|ABI2_uc002vac.2_Missense_Mutation_p.D271E|ABI2_uc010zin.1_Missense_Mutation_p.D162E	NM_005759	NP_005750	Q9NYB9	ABI2_HUMAN	abl interactor 2	485	SH3.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0						AGAAGAATGACGATGGTTGGT	0.423													17	29					0	0	0	0	G	204291988	G	G	204291988	3	3	297	1	0	0	0	0	1	0	0	0	89	535	19	3	1379	3	ABI2	2	204291988	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	36189860	204291988	38907385	25	54940											
WNT10A	80326	broad.mit.edu	37	chr2	219747032	219747032	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ggctgcctcagccatacaggGcatccagatcgccatccacg	9	6	10	16	2	1	1	1	0	0	1	4	1	3	1	5	2	3	2	5	2	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr2:219747032G>A	uc002vjd.1	+	2	726	c.263G>A	c.(262-264)GGC>GAC	p.G88D		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	88					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCATACAGGGCATCCAGATC	0.582													25	65					0	0	0	0	A	219747032	A	A	219747032	3	1	297	1	0	0	0	0	1	0	0	0	17450	1203	42	4	269	4	WNT10A	2	219747032	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	15455044	219747032	23452341	26	54941											
NMUR1	10316	broad.mit.edu	37	chr2	232393435	232393435	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccgacacggccaggctgaaGaggtagtagttggtaggcgt	9	8	16	8	3	0	2	0	1	0	1	1	3	1	2	2	5	0	5	2	5	4	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr2:232393435G>C	uc002vry.3	-	2	407	c.297C>G	c.(295-297)CTC>CTG	p.L99L		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	99	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CCAGGCTGAAGAGGTAGTAGT	0.622													38	71					0	0	0	0	C	232393435	C	C	232393435	2	2	297	1	0	0	0	0	0	0	0	1	10560	929	33	2		2	NMUR1	2	232393435	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	12646403	232393435	10805938	27	54942											
DGKD	8527	broad.mit.edu	37	chr2	234368410	234368410	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatgtctgctcagtgtcgcaCggtgaagatctccatccttg	7	12	11	11	2	3	2	1	1	2	1	6	3	4	2	2	1	1	2	2	1	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr2:234368410C>T	uc002vui.1	+	23	2714	c.2702C>T	c.(2701-2703)ACG>ATG	p.T901M	DGKD_uc002vuj.1_Missense_Mutation_p.T857M|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	901					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	CAGTGTCGCACGGTGAAGATC	0.562													14	32					0	0	0	0	T	234368410	T	T	234368410	3	4	297	1	0	0	0	0	1	0	0	0	4489	536	19	1	2816	1	DGKD	2	234368410	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	1974975	234368410	8830963	28	54943											
ITPR1	3708	broad.mit.edu	37	chr3	4725402	4725402	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtccatcgtggaaaagtcaGagctttgggtgtacaaaggg	11	9	15	6	1	1	1	1	0	0	1	3	2	2	2	1	4	2	2	1	4	4	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr3:4725402G>T	uc003bqa.2	+	28	3739	c.3391G>T	c.(3391-3393)GAG>TAG	p.E1131*	ITPR1_uc010hca.1_Nonsense_Mutation_p.E1116*|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Nonsense_Mutation_p.E62*	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	1140	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GGAAAAGTCAGAGCTTTGGGT	0.448													4	54					2.56e-06	4.55251e-06	1	0	T	4725402	T	T	4725402	4	4	297	1	0	0	0	0	0	1	0	0	7959	943	33	2	3520	2	ITPR1	3	4725402	Nonsense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08		4725402	193297028	29	54944											
NEK11	79858	broad.mit.edu	37	chr3	130748710	130748710	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttcagacaagaaagccaaacGaggagaggaattgtaagtaa	19	6	11	5	1	1	3	1	0	0	3	1	6	1	4	1	2	2	2	1	2	6	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr3:130748710G>C	uc003eny.2	+	3	484	c.158G>C	c.(157-159)CGA>CCA	p.R53P	NEK11_uc003enx.2_Missense_Mutation_p.R53P|NEK11_uc003eoa.2_Missense_Mutation_p.R53P|NEK11_uc003enz.2_5'UTR|NEK11_uc010htn.2_RNA|NEK11_uc011blk.1_5'UTR|NEK11_uc011bll.1_Missense_Mutation_p.R53P|NEK11_uc003enw.1_Missense_Mutation_p.R53P|NEK11_uc011blm.1_Missense_Mutation_p.R53P	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1	53	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						AAAGCCAAACGAGGAGAGGAA	0.383													17	38					0	0	0	0	C	130748710	C	C	130748710	3	2	297	1	0	0	0	0	1	0	0	0	10377	1058	37	3	160	3	NEK11	3	130748710	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	126023308	130748710	67273720	30	54945											
CLDN18	51208	broad.mit.edu	37	chr3	137717874	137717874	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgtggcgctcctgtgtccGagagagctctggcttcaccg	4	10	14	13	3	2	1	1	0	1	1	4	3	4	1	3	2	1	4	3	2	0	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr3:137717874G>A	uc003ero.1	+	1	217	c.164G>A	c.(163-165)CGA>CAA	p.R55Q		NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	55	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCCTGTGTCCGAGAGAGCTCT	0.602													28	73					0	0	0	0	A	137717874	A	A	137717874	3	1	297	1	0	0	0	0	1	0	0	0	3494	1058	37	1	166	1	CLDN18	3	137717874	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	6969164	137717874	60304556	31	54946											
FAM194A	131831	broad.mit.edu	37	chr3	150421899	150421900	+	5'Flank	INS	-	C	C																															cagacttctttctgtccctgINSctcttcagcgtctctgaaac																								rs148177227	by1000genomes	TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr3:150421899_150421900insC	uc003eyg.2	-						FAM194A_uc003eyh.2_5'Flank	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831											skin(2)|ovary(1)	3						TTCTGTCCCTGCTCTTCAGCGT	0.545													---	---	---								C	150421900	C	C	150421899	6	5	297	0	1	1	1	0	0	0	0	0	5554	1334	46	0		0	FAM194A	3	150421899	5'Flank	INS	-	TCGA-HD-7229-01A-11D-2012-08	12704025	150421899	47600531	32	54947											
SI	6476	broad.mit.edu	37	chr3	164754249	164754249	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acctaatgcgactataagtcCtagaggattcttacggctgt	11	12	9	9	2	1	1	0	0	1	1	2	3	2	2	2	2	2	1	2	2	5	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr3:164754249C>A	uc003fei.2	-	22	2505	c.2443G>T	c.(2443-2445)GGA>TGA	p.G815*		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	815	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACTATAAGTCCTAGAGGATTC	0.338										HNSCC(35;0.089)			15	43					0.000422831	0.000733857	1	0	A	164754249	A	A	164754249	4	1	297	1	0	0	0	0	0	1	0	0	14362	690	24	4	3148	4	SI	3	164754249	Nonsense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	14332350	164754249	33268181	33	54948											
ZBBX	79740	broad.mit.edu	37	chr3	167031903	167031903	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgacaatcatgaaaagcacAactttcacatgtaggaacaa	18	8	6	9	0	2	2	2	2	0	0	2	3	2	3	0	1	3	2	0	1	7	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr3:167031903A>C	uc003fep.2	-	16	1599	c.1276T>G	c.(1276-1278)TGT>GGT	p.C426G	ZBBX_uc011bpc.1_Missense_Mutation_p.C426G|ZBBX_uc003feq.2_Missense_Mutation_p.C397G	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	426						intracellular	zinc ion binding			ovary(2)	2						TGAAAAGCACAACTTTCACAT	0.284													4	73					0	0	0	0	C	167031903	C	C	167031903	3	2	297	1	0	0	0	0	1	0	0	0	17584	144	5	5	1150	5	ZBBX	3	167031903	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	2277654	167031903	30990527	34	54949											
NCEH1	57552	broad.mit.edu	37	chr3	172365793	172365793	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacaccatcaaagtctgtgtCggtcaccttcacttgggcag	9	10	9	13	1	4	0	3	0	1	0	5	0	4	0	2	2	0	1	2	2	1	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr3:172365793C>G	uc011bpx.1	-	2	484	c.346G>C	c.(346-348)GAC>CAC	p.D116H	NCEH1_uc003fig.2_Missense_Mutation_p.D116H|NCEH1_uc011bpw.1_5'UTR|NCEH1_uc011bpy.1_Intron	NM_001146276	NP_001139748	Q6PIU2	NCEH1_HUMAN	arylacetamide deacetylase-like 1 isoform a	84	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity				0						AAGTCTGTGTCGGTCACCTTC	0.517													13	83					0	0	0	0	G	172365793	G	G	172365793	3	3	297	1	0	0	0	0	1	0	0	0	10269	884	31	3	1016	3	NCEH1	3	172365793	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	5333890	172365793	25656637	35	54950											
KNG1	3827	broad.mit.edu	37	chr3	186459996	186459996	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctttcatttaacccaatatCagattttccagacacgacct	12	13	3	13	1	2	2	2	0	0	2	3	3	3	2	4	0	1	0	4	0	3	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr3:186459996C>T	uc011bsa.1	+	10	2023	c.1811C>T	c.(1810-1812)TCA>TTA	p.S604L	KNG1_uc003fqr.2_Intron	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	604					blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	AACCCAATATCAGATTTTCCA	0.423													32	114					0	0	0	0	T	186459996	T	T	186459996	3	4	297	1	0	0	0	0	1	0	0	0	8466	838	29	2	1849	2	KNG1	3	186459996	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	14094203	186459996	11562434	36	54951											
EVC2	132884	broad.mit.edu	37	chr4	5586437	5586437	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tccaggagcaagtcctggatGctgaggagggcggtgtaggc	8	7	18	8	1	0	1	0	1	0	0	2	4	2	4	2	6	2	3	2	6	2	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr4:5586437G>C	uc003gij.2	-	17	3024	c.2970C>G	c.(2968-2970)AGC>AGG	p.S990R	EVC2_uc011bwb.1_Missense_Mutation_p.S430R|EVC2_uc003gik.2_Missense_Mutation_p.S910R	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	990						integral to membrane				large_intestine(3)|ovary(2)	5						AGTCCTGGATGCTGAGGAGGG	0.617													6	38					0	0	0	0	C	5586437	C	C	5586437	3	2	297	1	0	0	0	0	1	0	0	0	5310	1310	46	4	980	4	EVC2	4	5586437	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08		5586437	185567839	37	54952											
SHROOM3	57619	broad.mit.edu	37	chr4	77660159	77660159	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtatccacaccctggcatctCtggccgggagcgttcaggct	6	9	12	14	2	2	0	1	0	1	0	4	1	3	1	3	4	1	4	3	4	1	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr4:77660159C>G	uc011cbx.1	+	5	1786	c.833C>G	c.(832-834)TCT>TGT	p.S278C	SHROOM3_uc011cbz.1_Missense_Mutation_p.S102C|SHROOM3_uc003hkf.1_Missense_Mutation_p.S153C|SHROOM3_uc003hkg.2_Missense_Mutation_p.S56C	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	278					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CCTGGCATCTCTGGCCGGGAG	0.527													17	64					0	0	0	0	G	77660159	G	G	77660159	3	3	297	1	0	0	0	0	1	0	0	0	14360	913	32	2	851	2	SHROOM3	4	77660159	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	72073722	77660159	113494117	38	54953											
C4orf21	55345	broad.mit.edu	37	chr4	113462064	113462064	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgattgaatcagcttgagTgtaaacgtagcttctgccac	11	12	10	8	1	2	3	1	3	1	0	2	3	2	3	1	0	4	4	1	0	4	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr4:113462064T>A	uc003iau.2	-	26	6034	c.5823A>T	c.(5821-5823)ACA>ACT	p.T1941T	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Silent_p.T399T	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	763						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TCAGCTTGAGTGTAAACGTAG	0.358													5	5					0	0	0	0	A	113462064	A	A	113462064	2	1	297	1	0	0	0	0	0	0	0	1	2264	1683	59	5		5	C4orf21	4	113462064	Silent	SNP	T	TCGA-HD-7229-01A-11D-2012-08	35801905	113462064	77692212	39	54954											
GYPA	2993	broad.mit.edu	37	chr4	145039887	145039887	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ctggttcagagaaatgatggGcaagttgtaccctttctcct	9	13	10	9	0	2	2	1	1	1	1	3	3	2	2	2	2	1	4	2	2	3	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr4:145039887G>A	uc003ijo.3	-	4	367	c.251C>T	c.(250-252)GCC>GTC	p.A84V	GYPA_uc003ijn.2_Missense_Mutation_p.A84V|GYPA_uc011cia.1_RNA|GYPA_uc011cib.1_Missense_Mutation_p.A51V|GYPA_uc003ijp.3_Missense_Mutation_p.A52V|GYPA_uc010ioq.2_Intron|GYPA_uc010ior.2_Missense_Mutation_p.A19V|GYPA_uc010ios.1_Intron	NM_002099	NP_002090	P02724	GLPA_HUMAN	glycophorin A precursor	84	Extracellular.		A -> P (in ENEP/HAG antigen).		interspecies interaction between organisms	membrane fraction	receptor activity	p.A84T(1)		central_nervous_system(2)	2	all_hematologic(180;0.15)					GAAATGATGGGCAAGTTGTAC	0.313													36	17					0	0	0	0	A	145039887	A	A	145039887	3	1	297	1	0	0	0	0	1	0	0	0	6947	1203	42	4	217	4	GYPA	4	145039887	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	31577823	145039887	46114389	40	54955											
GUCY1B3	2983	broad.mit.edu	37	chr4	156724819	156724819	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tatgacagtgagtggtttacCagagccatgcattcaccatg	11	11	10	9	0	1	3	1	2	0	1	1	3	1	3	3	1	3	2	3	1	2	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr4:156724819C>T	uc003ipc.2	+	11	1624	c.1457C>T	c.(1456-1458)CCA>CTA	p.P486L	GUCY1B3_uc011cio.1_Missense_Mutation_p.P508L|GUCY1B3_uc011cip.1_Missense_Mutation_p.P466L|GUCY1B3_uc003ipd.2_Missense_Mutation_p.P414L|GUCY1B3_uc010iqf.2_Missense_Mutation_p.P453L|GUCY1B3_uc010iqg.2_Missense_Mutation_p.P457L|GUCY1B3_uc011ciq.1_Missense_Mutation_p.P414L	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	486	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AGTGGTTTACCAGAGCCATGC	0.428													10	9					0	0	0	0	T	156724819	T	T	156724819	3	4	297	1	0	0	0	0	1	0	0	0	6934	594	21	4	1499	4	GUCY1B3	4	156724819	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	11684932	156724819	34429457	41	54956											
NPY1R	4886	broad.mit.edu	37	chr4	164247590	164247590	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaagagctaaggtaaatatCatggccaagggcagatgaca	16	6	12	7	0	1	3	1	1	0	2	1	3	1	3	1	3	1	4	1	3	6	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr4:164247590C>A	uc003iqm.1	-	2	383	c.117G>T	c.(115-117)ATG>ATT	p.M39I	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	39	Extracellular (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AGGTAAATATCATGGCCAAGG	0.408													32	24					5.45727e-16	1.03145e-15	1	0	A	164247590	A	A	164247590	3	1	297	1	0	0	0	0	1	0	0	0	10662	826	29	2	1045	2	NPY1R	4	164247590	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	7522771	164247590	26906686	42	54957											
TRIO	7204	broad.mit.edu	37	chr5	14477072	14477072	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggatccctttttgttaaacaCgtaagcacaatagcattgct	12	13	7	9	1	0	0	0	0	0	0	1	1	1	1	1	1	4	5	1	1	5	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr5:14477072C>G	uc003jff.2	+	41	6159	c.6153C>G	c.(6151-6153)CAC>CAG	p.H2051Q	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Missense_Mutation_p.H1700Q	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2051	DH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TTGTTAAACACGTAAGCACAA	0.353													4	20					0	0	0	0	G	14477072	G	G	14477072	3	3	297	1	0	0	0	0	1	0	0	0	16619	550	19	3	6315	3	TRIO	5	14477072	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		14477072	166438188	43	54958											
CDH18	1016	broad.mit.edu	37	chr5	19483518	19483518	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcacacgcccatctctctCgcatgcacaaaccctgatgg	9	7	7	18	3	2	1	0	1	2	0	4	1	2	1	3	1	2	3	3	1	1	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr5:19483518C>A	uc003jgc.2	-	11	2151	c.1774G>T	c.(1774-1776)GAG>TAG	p.E592*	CDH18_uc003jgd.2_Nonsense_Mutation_p.E592*|CDH18_uc011cnm.1_Silent_p.A555A	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	592	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CCATCTCTCTCGCATGCACAA	0.517													9	31					0.00448238	0.00766891	1	0	A	19483518	A	A	19483518	4	1	297	1	0	0	0	0	0	1	0	0	3118	893	31	3	606	3	CDH18	5	19483518	Nonsense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	5006446	19483518	161431742	44	54959											
FBN2	2201	broad.mit.edu	37	chr5	127614517	127614517	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcagtacctctgcaaagcaGagaccctgtcgattgtctga	10	10	10	11	1	2	2	0	1	2	1	3	4	2	2	2	0	4	4	2	0	2	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr5:127614517G>C	uc003kuu.2	-	57	7594	c.7155C>G	c.(7153-7155)CTC>CTG	p.L2385L		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2385	TB 9.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTGCAAAGCAGAGACCCTGTC	0.468													13	29					0	0	0	0	C	127614517	C	C	127614517	2	2	297	1	0	0	0	0	0	0	0	1	5735	929	33	2		2	FBN2	5	127614517	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	108130999	127614517	53300743	45	54960											
C5orf20	140947	broad.mit.edu	37	chr5	134782555	134782555	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaattgaactgccccctctcGcaggaccccagctggcaagg	9	6	11	15	1	1	1	0	1	1	0	2	3	1	2	4	3	3	3	4	3	3	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr5:134782555G>A	uc003lav.2	-	1	484	c.244C>T	c.(244-246)CGA>TGA	p.R82*		NM_130848	NP_570900	Q8TF63	DCNP1_HUMAN	dendritic cell nuclear protein 1	82						nucleus					0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCCCCCTCTCGCAGGACCCCA	0.592													19	54					0	0	0	0	A	134782555	A	A	134782555	4	1	297	1	0	0	0	0	0	1	0	0	2294	1095	38	1	494	1	C5orf20	5	134782555	Nonsense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	7168038	134782555	46132705	46	54961											
PCDHB9	56127	broad.mit.edu	37	chr5	140568207	140568207	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccgagcacagcataacccTgcaggtctccgacgtcaatg	12	6	9	14	3	2	0	1	0	1	0	3	2	2	0	3	1	5	3	3	1	3	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr5:140568207T>C	uc003liw.1	+	3	1316	c.1316T>C	c.(1315-1317)CTG>CCG	p.L439P		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	439	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCATAACCCTGCAGGTCTCC	0.582													59	156					0	0	0	0	C	140568207	C	C	140568207	3	2	297	1	0	0	0	0	1	0	0	0	11603	1580	55	5	1317	5	PCDHB9	5	140568207	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08	5785652	140568207	40347053	47	54962											
DSP	1832	broad.mit.edu	37	chr6	7579931	7579931	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccatcaaggagaaggagtacGagattgaaaggttgagggtt	14	8	15	4	1	1	4	1	2	0	2	1	7	1	5	1	4	1	3	1	4	4	4	rs139582608		TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:7579931G>A	uc003mxp.1	+	23	3787	c.3508G>A	c.(3508-3510)GAG>AAG	p.E1170K	DSP_uc003mxq.1_Missense_Mutation_p.E1170K	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1170	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton	p.E1170K(1)		central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GAAGGAGTACGAGATTGAAAG	0.438													9	15					0	0	0	0	A	7579931	A	A	7579931	3	1	297	1	0	0	0	0	1	0	0	0	4803	1059	37	1	3598	1	DSP	6	7579931	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08		7579931	163535136	48	54963											
JARID2	3720	broad.mit.edu	37	chr6	15517481	15517481	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctgccgagggctgaagttGatgtaccgctacgatgaggt	8	10	14	9	3	0	3	0	3	0	0	1	5	1	3	3	2	3	4	3	2	3	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:15517481G>C	uc003nbj.2	+	17	3784	c.3540G>C	c.(3538-3540)TTG>TTC	p.L1180F	JARID2_uc011div.1_Missense_Mutation_p.L1008F	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	1180					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				GGCTGAAGTTGATGTACCGCT	0.622													18	66					0	0	0	0	C	15517481	C	C	15517481	3	2	297	1	0	0	0	0	1	0	0	0	7984	1281	45	2	3606	2	JARID2	6	15517481	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	7937550	15517481	155597586	49	54964											
KDM1B	221656	broad.mit.edu	37	chr6	18208370	18208370	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gctttttgagcaggtgcagtGtattgattattctggagatg	8	16	13	4	0	1	3	0	2	1	1	1	4	1	3	0	2	2	4	0	2	2	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:18208370G>T	uc003nco.1	+	10	1265	c.1190G>T	c.(1189-1191)TGT>TTT	p.C397F	KDM1B_uc003ncn.1_Missense_Mutation_p.C368F	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	600					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						CAGGTGCAGTGTATTGATTAT	0.428													12	60					0.000308642	0.00053826	1	0	T	18208370	T	T	18208370	3	4	297	1	0	0	0	0	1	0	0	0	8162	1377	48	4	1145	4	KDM1B	6	18208370	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	2690889	18208370	152906697	50	54965											
HIST1H1B	3009	broad.mit.edu	37	chr6	27834778	27834778	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcggtttggcagcggccttgGccttcttagggctcttcgcc	2	13	13	13	3	2	0	0	0	2	0	4	0	2	0	3	5	1	3	3	5	1	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:27834778G>A	uc003njx.2	-	1	582	c.530C>T	c.(529-531)GCC>GTC	p.A177V		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	177					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						AGCGGCCTTGGCCTTCTTAGG	0.587													45	91					0	0	0	0	A	27834778	A	A	27834778	3	1	297	1	0	0	0	0	1	0	0	0	7162	1203	42	4	154	4	HIST1H1B	6	27834778	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	9626408	27834778	143280289	51	54966											
ATP6V1G2	534	broad.mit.edu	37	chr6	31514269	31514269	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcactctttctggcatctGccaccttctcagctgcccgc	5	12	6	18	1	5	0	2	0	4	0	6	0	5	0	3	1	3	2	3	1	0	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:31514269G>T	uc003nua.2	-	1	359	c.68C>A	c.(67-69)GCA>GAA	p.A23E	BAT1_uc003ntv.2_5'UTR|ATP6V1G2_uc003ntz.2_Intron|NFKBIL1_uc011dnr.1_5'Flank|NFKBIL1_uc011dns.1_5'Flank|NFKBIL1_uc011dnt.1_5'Flank|NFKBIL1_uc003nuc.2_5'Flank|NFKBIL1_uc003nub.2_5'Flank	NM_130463	NP_569730	O95670	VATG2_HUMAN	ATPase, H+ transporting, lysosomal, V1 subunit	23					cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport	cytosol|melanosome|vacuolar proton-transporting V-type ATPase complex	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|protein binding				0						TCTGGCATCTGCCACCTTCTC	0.512													7	17					0.00198382	0.00341028	1	0	T	31514269	T	T	31514269	3	4	297	1	0	0	0	0	1	0	0	0	1189	1319	46	4	300	4	ATP6V1G2	6	31514269	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	3679491	31514269	139600798	52	54967											
ZNF318	24149	broad.mit.edu	37	chr6	43323114	43323114	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaggaacagcggtcagctGagaagcggtggtcaactgag	11	6	16	8	2	2	3	2	3	0	1	2	5	2	4	0	4	5	1	0	4	3	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:43323114G>A	uc003oux.2	-	4	2036	c.1958C>T	c.(1957-1959)TCA>TTA	p.S653L	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	653					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GCGGTCAGCTGAGAAGCGGTG	0.537													28	83					0	0	0	0	A	43323114	A	A	43323114	3	1	297	1	0	0	0	0	1	0	0	0	17903	1294	45	2	4909	2	ZNF318	6	43323114	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	11808845	43323114	127791953	53	54968											
GPR110	266977	broad.mit.edu	37	chr6	46977268	46977268	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aaaccagacatcagcaatcaAgagggacagggctatgttca	16	6	10	9	0	3	2	3	0	0	2	3	3	3	3	1	2	2	3	1	2	4	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:46977268A>C	uc003oyt.2	-	11	2102	c.1903T>G	c.(1903-1905)TTG>GTG	p.L635V	GPR110_uc011dwl.1_Missense_Mutation_p.L323V	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	635	Helical; Name=2; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TCAGCAATCAAGAGGGACAGG	0.458													15	17					0	0	0	0	C	46977268	C	C	46977268	3	2	297	1	0	0	0	0	1	0	0	0	6665	69	3	5	849	5	GPR110	6	46977268	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	3654154	46977268	124137799	54	54969											
MDN1	23195	broad.mit.edu	37	chr6	90384055	90384055	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acaaagttgtcccttgctaaGttctggtccttccaggcagg	8	12	10	11	0	1	0	0	0	1	0	4	0	4	0	3	3	1	4	3	3	2	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:90384055G>T	uc003pnn.1	-	79	13131	c.13015C>A	c.(13015-13017)CTT>ATT	p.L4339I		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4339					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CCCTTGCTAAGTTCTGGTCCT	0.587													37	39					3.93418e-24	7.59486e-24	1	0	T	90384055	T	T	90384055	3	4	297	1	0	0	0	0	1	0	0	0	9468	1029	36	4	3871	4	MDN1	6	90384055	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	43406787	90384055	80731012	55	54970											
SOBP	55084	broad.mit.edu	37	chr6	107824913	107824913	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggctggtatggctatgataAggttgaattaaaagatggtg	12	13	14	2	0	0	3	0	2	0	1	0	3	0	3	0	5	0	4	0	5	6	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:107824913A>C	uc003prx.2	+	2	653	c.149A>C	c.(148-150)AAG>ACG	p.K50T	SOBP_uc003prw.1_Missense_Mutation_p.K50T	NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	50							metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GGCTATGATAAGGTTGAATTA	0.388													19	108					0	0	0	0	C	107824913	C	C	107824913	3	2	297	1	0	0	0	0	1	0	0	0	14976	72	3	5	155	5	SOBP	6	107824913	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	17440858	107824913	63290154	56	54971											
RSPH4A	345895	broad.mit.edu	37	chr6	116949485	116949485	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaagtgattgatctagtaGaatccctatccaattgggtt	11	14	8	8	0	1	3	0	2	1	1	4	3	4	3	3	1	0	2	3	1	6	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:116949485G>C	uc003pxe.2	+	3	1760	c.1615G>C	c.(1615-1617)GAA>CAA	p.E539Q	RSPH4A_uc010kee.2_Missense_Mutation_p.E539Q	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	539	Glu-rich.				cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						TGATCTAGTAGAATCCCTATC	0.423									Kartagener_syndrome				25	144					0	0	0	0	C	116949485	C	C	116949485	3	2	297	1	0	0	0	0	1	0	0	0	13771	943	33	2	1625	2	RSPH4A	6	116949485	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	9124572	116949485	54165582	57	54972											
FAM162B	221303	broad.mit.edu	37	chr6	117086702	117086702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcagcggactgttagcccgCggccaaggcgcagtaggctc	7	5	15	14	5	0	0	0	0	0	0	1	1	0	1	2	4	2	5	2	4	3	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:117086702C>T	uc003pxi.2	-	1	185	c.38G>A	c.(37-39)CGC>CAC	p.R13H		NM_001085480	NP_001078949	Q5T6X4	F162B_HUMAN	hypothetical protein LOC221303	13						integral to membrane					0						TGTTAGCCCGCGGCCAAGGCG	0.761													7	6					0	0	0	0	T	117086702	T	T	117086702	3	4	297	1	0	0	0	0	1	0	0	0	5503	768	27	1	466	1	FAM162B	6	117086702	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	137217	117086702	54028365	58	54973											
RFX6	222546	broad.mit.edu	37	chr6	117246774	117246774	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aacctggaggcctaggccctGctctgcaccagttccctgct	6	9	10	16	0	1	0	0	0	1	0	2	1	2	1	5	3	4	4	5	3	2	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:117246774G>A	uc003pxm.2	+	16	1900	c.1837G>A	c.(1837-1839)GCT>ACT	p.A613T		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	613					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						CCTAGGCCCTGCTCTGCACCA	0.547													38	81					0	0	0	0	A	117246774	A	A	117246774	3	1	297	1	0	0	0	0	1	0	0	0	13332	1319	46	4	1899	4	RFX6	6	117246774	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	160072	117246774	53868293	59	54974											
LAMA2	3908	broad.mit.edu	37	chr6	129637001	129637001	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	taatcctcaagtgatcattcGaggtgggacacctactcatg	11	11	9	10	1	3	1	3	1	0	0	5	3	4	2	2	2	1	0	2	2	3	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:129637001G>C	uc003qbn.2	+	26	3935	c.3830G>C	c.(3829-3831)CGA>CCA	p.R1277P	LAMA2_uc003qbo.2_Missense_Mutation_p.R1277P	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1277	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GTGATCATTCGAGGTGGGACA	0.443													141	71					0	0	0	0	C	129637001	C	C	129637001	3	2	297	1	0	0	0	0	1	0	0	0	8646	1058	37	3	3932	3	LAMA2	6	129637001	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	12390227	129637001	41478066	60	54975											
TMEM181	57583	broad.mit.edu	37	chr6	159050835	159050835	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctttgtatattctccatcGaagaatgccctctatggtaa	10	14	7	10	1	2	1	0	0	2	1	4	2	2	1	3	1	1	2	3	1	6	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:159050835G>A	uc003qrm.3	+	15	1688	c.1677G>A	c.(1675-1677)TCG>TCA	p.S559S		NM_020823	NP_065874	Q9P2C4	TM181_HUMAN	G protein-coupled receptor 178	559					pathogenesis	integral to membrane	toxin binding			ovary(2)|central_nervous_system(1)	3		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		ATTCTCCATCGAAGAATGCCC	0.542													41	42					0	0	0	0	A	159050835	A	A	159050835	2	1	297	1	0	0	0	0	0	0	0	1	16166	1045	37	1		1	TMEM181	6	159050835	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	29413834	159050835	12064232	61	54976											
AGPAT4	56895	broad.mit.edu	37	chr6	161575210	161575210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctcggggtagtcccggaggtGctgcaaactggtggcaaccg	7	7	16	11	3	0	0	0	0	0	0	2	1	1	1	2	6	4	4	2	6	3	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:161575210G>A	uc003qtr.1	-	4	708	c.481C>T	c.(481-483)CAC>TAC	p.H161Y	AGPAT4_uc003qts.1_Missense_Mutation_p.H21Y|AGPAT4_uc011egb.1_Intron|AGPAT4_uc003qtt.1_RNA|AGPAT4_uc011egc.1_Missense_Mutation_p.H161Y|AGPAT4_uc011egd.1_Missense_Mutation_p.H99Y|AGPAT4_uc011ege.1_Missense_Mutation_p.A104V	NM_020133	NP_064518	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	161					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding				0		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		TCCCGGAGGTGCTGCAAACTG	0.567													24	38					0	0	0	0	A	161575210	A	A	161575210	3	1	297	1	0	0	0	0	1	0	0	0	389	1319	46	4	679	4	AGPAT4	6	161575210	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	2524375	161575210	9539857	62	54977											
GPR31	2853	broad.mit.edu	37	chr6	167570533	167570533	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gctgcccgtgacatccgaggTatgagccactgcacaaaggg	10	6	13	12	2	0	2	0	2	0	0	1	3	1	2	3	2	3	3	3	2	2	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:167570533T>C	uc011egq.1	-	1	787	c.787A>G	c.(787-789)ACC>GCC	p.T263A		NM_005299	NP_005290	O00270	GPR31_HUMAN	G protein-coupled receptor 31	263	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		ACATCCGAGGTATGAGCCACT	0.587													32	43					0	0	0	0	C	167570533	C	C	167570533	3	2	297	1	0	0	0	0	1	0	0	0	6725	1638	57	5	175	5	GPR31	6	167570533	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08	5995323	167570533	3544534	63	54978											
THBS2	7058	broad.mit.edu	37	chr6	169640559	169640559	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggcctcaccttgcaggtacaCgtggtgcagctgtccaccac	7	8	11	15	1	1	0	1	0	0	0	2	0	2	0	4	3	4	4	4	3	1	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr6:169640559C>G	uc003qwt.2	-	7	1268	c.1020G>C	c.(1018-1020)ACG>ACC	p.T340T		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	340	VWFC.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TGCAGGTACACGTGGTGCAGC	0.572													21	32					0	0	0	0	G	169640559	G	G	169640559	2	3	297	1	0	0	0	0	0	0	0	1	15920	523	19	3		3	THBS2	6	169640559	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	2070026	169640559	1474508	64	54979											
RADIL	55698	broad.mit.edu	37	chr7	4839063	4839063	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgtttccacgtcggacttCgcgaccaggaaccgcatctt	7	10	10	14	5	1	0	0	0	1	0	4	3	2	2	3	2	1	3	3	2	1	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:4839063C>T	uc003snj.1	-	15	3347	c.3174G>A	c.(3172-3174)GCG>GCA	p.A1058A	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Silent_p.A563A|RADIL_uc011jwc.1_Silent_p.A818A|RADIL_uc011jwd.1_RNA|RADIL_uc003snh.1_Silent_p.A354A	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	1058	PDZ.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CGTCGGACTTCGCGACCAGGA	0.647													124	48					0	0	0	0	T	4839063	T	T	4839063	2	4	297	1	0	0	0	0	0	0	0	1	13062	871	31	1		1	RADIL	7	4839063	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08		4839063	154299600	65	54980											
MEOX2	4223	broad.mit.edu	37	chr7	15652017	15652017	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggtcctctgtttatatcataAgtgcgcatgctctgagctgt	7	15	10	9	1	3	1	1	1	2	0	4	1	4	1	1	1	3	4	1	1	3	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:15652017A>G	uc003stc.2	-	3	1191	c.910T>C	c.(910-912)TTA>CTA	p.L304L	MEOX2_uc011jxw.1_Silent_p.L304L	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	304					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TTATATCATAAGTGCGCATGC	0.478													9	204					0	0	0	0	G	15652017	G	G	15652017	2	3	297	1	0	0	0	0	0	0	0	1	9527	69	3	5		5	MEOX2	7	15652017	Silent	SNP	A	TCGA-HD-7229-01A-11D-2012-08	10812954	15652017	143486646	66	54981											
DNAH11	8701	broad.mit.edu	37	chr7	21639563	21639563	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaacaattgaaaccggcaccGttttttcaagcacaaatgat	16	10	6	9	2	1	2	1	2	0	0	1	2	1	2	2	1	3	3	2	1	5	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:21639563G>T	uc003svc.2	+	15	2857	c.2826G>T	c.(2824-2826)CCG>CCT	p.P942P		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	942	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AACCGGCACCGTTTTTTCAAG	0.408									Kartagener_syndrome				45	19					1.15505e-17	2.2062e-17	1	0	T	21639563	T	T	21639563	2	4	297	1	0	0	0	0	0	0	0	1	4621	1132	40	3		3	DNAH11	7	21639563	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	5987546	21639563	137499100	67	54982											
PCLO	27445	broad.mit.edu	37	chr7	82583946	82583946	+	Frame_Shift_Del	DEL	G	-	-																															acgctcctgagagaacacttGatgtcaaagaggcatctggc																										TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:82583946delG	uc003uhx.2	-	5	6612	c.6323delC	c.(6322-6324)TCAfs	p.S2108fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.S2108fs	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2039					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GAGAACACTTGATGTCAAAGA	0.453													---	---	---								-	82583946	-	-	82583946	7	5	297	1	0	1	0	1	0	0	0	0	11637	1294	45	0	9206	0	PCLO	7	82583946	Frame_Shift_Del	DEL	G	TCGA-HD-7229-01A-11D-2012-08	60944383	82583946	76554717	68	54983											
AKAP9	10142	broad.mit.edu	37	chr7	91630769	91630769	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctctcaaaaggaaaaactcaAggaagaactaggactaattt	19	8	7	7	0	2	1	2	0	1	1	3	4	2	4	0	3	2	0	0	3	9	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:91630769A>T	uc003ulg.2	+	8	1763	c.1538A>T	c.(1537-1539)AAG>ATG	p.K513M	AKAP9_uc003ule.2_Missense_Mutation_p.K525M|AKAP9_uc003ulf.2_Missense_Mutation_p.K513M|AKAP9_uc003uli.2_Missense_Mutation_p.K138M	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	525	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAAAAACTCAAGGAAGAACTA	0.323			T	BRAF	papillary thyroid								18	51					0	0	0	0	T	91630769	T	T	91630769	3	4	297	1	0	0	0	0	1	0	0	0	459	72	3	5	1568	5	AKAP9	7	91630769	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	9046823	91630769	67507894	69	54984											
METTL2B	55798	broad.mit.edu	37	chr7	128119472	128119472	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ttgaacataaaacacagacaCctcctgtggaggagaatgta	16	8	9	8	0	0	3	0	1	0	2	1	5	1	4	2	2	2	1	2	2	5	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:128119472C>T	uc003vnf.2	+	3	500	c.463C>T	c.(463-465)CCT>TCT	p.P155S	METTL2B_uc003vng.2_Missense_Mutation_p.P90S|METTL2B_uc011kop.1_Missense_Mutation_p.P19S	NM_018396	NP_060866	Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	155							methyltransferase activity			skin(1)	1						AACACAGACACCTCCTGTGGA	0.423													9	98					0	0	0	0	T	128119472	T	T	128119472	3	4	297	1	0	0	0	0	1	0	0	0	9553	507	18	4	473	4	METTL2B	7	128119472	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	36488703	128119472	31019191	70	54985											
MEST	4232	broad.mit.edu	37	chr7	130139737	130139737	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatctttcctgagactcaccGtccactccttctccaaaagg	9	12	5	15	1	3	1	1	1	2	1	7	2	6	1	5	1	0	0	5	1	3	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:130139737G>A	uc003vqg.2	+	7	774	c.557G>A	c.(556-558)CGT>CAT	p.R186H	MEST_uc003vqc.2_Missense_Mutation_p.R177H|MEST_uc003vqd.2_Missense_Mutation_p.R177H|MEST_uc003vqf.2_Missense_Mutation_p.R177H|MEST_uc011kph.1_Missense_Mutation_p.R172H|MEST_uc010lmg.2_Missense_Mutation_p.R186H	NM_002402	NP_002393	Q5EB52	MEST_HUMAN	mesoderm specific transcript isoform a	186					mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)					GAGACTCACCGTCCACTCCTT	0.328													16	52					0	0	0	0	A	130139737	A	A	130139737	3	1	297	1	0	0	0	0	1	0	0	0	9537	1145	40	1	583	1	MEST	7	130139737	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	2020265	130139737	28998926	71	54986											
KIAA1549	57670	broad.mit.edu	37	chr7	138603742	138603742	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcgttgtgttctgccagccCgatgtcacttcttcatcttg	4	15	9	13	3	5	0	2	0	3	0	5	1	5	0	2	0	2	2	2	0	0	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:138603742C>T	uc011kql.1	-	2	679	c.630G>A	c.(628-630)TCG>TCA	p.S210S	KIAA1549_uc003vuk.3_Silent_p.S160S|KIAA1549_uc011kqj.1_Silent_p.S210S	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	210						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TCTGCCAGCCCGATGTCACTT	0.522			O	BRAF	pilocytic astrocytoma								6	129					0	0	0	0	T	138603742	T	T	138603742	2	4	297	1	0	0	0	0	0	0	0	1	8283	639	23	1		1	KIAA1549	7	138603742	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	8464005	138603742	20534921	72	54987											
GIMAP1	170575	broad.mit.edu	37	chr7	150417387	150417387	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaagacagatcctggctgtGaggagagaggtcactgctac	11	7	13	10	0	1	4	1	1	0	3	2	6	2	5	2	3	2	2	2	3	2	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:150417387G>A	uc003whq.2	+	3	382	c.295G>A	c.(295-297)GAG>AAG	p.E99K	GIMAP1_uc003whp.2_Missense_Mutation_p.E107K	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	99	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCCTGGCTGTGAGGAGAGAGG	0.647													22	45					0	0	0	0	A	150417387	A	A	150417387	3	1	297	1	0	0	0	0	1	0	0	0	6416	1291	45	2	301	2	GIMAP1	7	150417387	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	11813645	150417387	8721276	73	54988											
NUB1	51667	broad.mit.edu	37	chr7	151073852	151073852	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccgagctgccgctgtcgccaGaagactctttgtccccgcca	6	8	10	17	4	1	2	0	0	1	2	3	3	2	2	6	0	2	2	6	0	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:151073852G>C	uc003wjx.2	+	14	1701	c.1696G>C	c.(1696-1698)GAA>CAA	p.E566Q	NUB1_uc003wjw.2_Missense_Mutation_p.E528Q|NUB1_uc010lqc.2_RNA	NM_016118	NP_057202	Q9Y5A7	NUB1_HUMAN	NEDD8 ultimate buster-1	542					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding				0			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		GCTGTCGCCAGAAGACTCTTT	0.612													2	7					0	0	0	0	C	151073852	C	C	151073852	3	2	297	1	0	0	0	0	1	0	0	0	10768	943	33	2	1632	2	NUB1	7	151073852	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	656465	151073852	8064811	74	54989											
MLL3	58508	broad.mit.edu	37	chr7	151945611	151945611	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atttgatcttcgccacaaatAtgcttcacttcagaagacat	13	13	5	10	1	3	3	2	1	1	2	4	3	3	3	1	0	1	1	1	0	3	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr7:151945611A>C	uc003wla.2	-	14	2127	c.1908T>G	c.(1906-1908)CAT>CAG	p.H636Q		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	636					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CGCCACAAATATGCTTCACTT	0.363			N		medulloblastoma								21	44					0	0	0	0	C	151945611	C	C	151945611	3	2	297	1	0	0	0	0	1	0	0	0	9675	446	16	5	13011	5	MLL3	7	151945611	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	871759	151945611	7193052	75	54990											
PTDSS1	9791	broad.mit.edu	37	chr8	97321825	97321825	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccgacacacagtgcaagcgcGtaggaacacaatgctgggtg	12	5	13	11	3	0	0	0	0	0	0	0	2	0	1	1	2	4	3	1	2	4	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr8:97321825G>C	uc003yht.1	+	9	1150	c.1048G>C	c.(1048-1050)GTA>CTA	p.V350L	PTDSS1_uc003yhu.1_Missense_Mutation_p.V204L	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	350					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	GTGCAAGCGCGTAGGAACACA	0.433													6	48					0	0	0	0	C	97321825	C	C	97321825	3	2	297	1	0	0	0	0	1	0	0	0	12798	1145	40	3	1082	3	PTDSS1	8	97321825	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08		97321825	49042197	76	54991											
FAM83A	84985	broad.mit.edu	37	chr8	124204207	124204207	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagatctctgacagtcacctCaaggtaggggccccaatgag	11	7	11	12	0	3	3	2	2	1	1	4	3	3	3	3	3	0	1	3	3	3	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr8:124204207C>T	uc003ypv.2	+	3	2659	c.645C>T	c.(643-645)CTC>CTT	p.L215L	FAM83A_uc003ypw.2_Silent_p.L215L|FAM83A_uc003ypy.2_Intron|FAM83A_uc003ypx.2_Silent_p.L215L|FAM83A_uc003ypz.2_Silent_p.L215L	NM_032899	NP_116288	Q86UY5	FA83A_HUMAN	hypothetical protein LOC84985 isoform a	215										ovary(3)|skin(1)	4	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			ACAGTCACCTCAAGGTAGGGG	0.373													38	174					0	0	0	0	T	124204207	T	T	124204207	2	4	297	1	0	0	0	0	0	0	0	1	5665	813	29	2		2	FAM83A	8	124204207	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	26882382	124204207	22159815	77	54992											
FAM135B	51059	broad.mit.edu	37	chr8	139163587	139163587	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccttgggcacagatgagAaagggagacaggtggcagtg	11	7	16	7	0	1	3	0	1	1	3	2	5	1	3	1	4	0	2	1	4	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr8:139163587A>T	uc003yuy.2	-	13	3302	c.3131T>A	c.(3130-3132)TTC>TAC	p.F1044Y	FAM135B_uc003yux.2_Missense_Mutation_p.F945Y|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.F606Y|FAM135B_uc003yvb.2_Missense_Mutation_p.F606Y	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1044										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CACAGATGAGAAAGGGAGACA	0.532										HNSCC(54;0.14)			34	46					0	0	0	0	T	139163587	T	T	139163587	3	4	297	1	0	0	0	0	1	0	0	0	5477	246	9	5	1121	5	FAM135B	8	139163587	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	14959380	139163587	7200435	78	54993											
PLEC	5339	broad.mit.edu	37	chr8	144996309	144996309	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgcacgccctcctcggcctcAtgctgccgccgccgcgcctc	2	6	10	23	7	1	0	1	0	0	0	4	0	2	0	7	1	2	2	7	1	0	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr8:144996309A>G	uc003zaf.1	-	32	8261	c.8091T>C	c.(8089-8091)CAT>CAC	p.H2697H	PLEC_uc003zab.1_Silent_p.H2560H|PLEC_uc003zac.1_Silent_p.H2564H|PLEC_uc003zad.2_Silent_p.H2560H|PLEC_uc003zae.1_Silent_p.H2528H|PLEC_uc003zag.1_Silent_p.H2538H|PLEC_uc003zah.2_Silent_p.H2546H|PLEC_uc003zaj.2_Silent_p.H2587H	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2697	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCTCGGCCTCATGCTGCCGCC	0.398													7	3					0	0	0	0	G	144996309	G	G	144996309	2	3	297	1	0	0	0	0	0	0	0	1	12107	214	8	5		5	PLEC	8	144996309	Silent	SNP	A	TCGA-HD-7229-01A-11D-2012-08	5832722	144996309	1367713	79	54994											
DCAF12	25853	broad.mit.edu	37	chr9	34125196	34125196	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cattctgtagcctgacttccCggttcttcaagtagtatact	8	15	7	11	1	3	1	1	1	2	0	4	1	4	1	2	1	2	4	2	1	5	8			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr9:34125196C>G	uc003ztt.2	-	2	500	c.158G>C	c.(157-159)CGG>CCG	p.R53P		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	53						centrosome|CUL4 RING ubiquitin ligase complex					0						CCTGACTTCCCGGTTCTTCAA	0.453													16	42					0	0	0	0	G	34125196	G	G	34125196	3	3	297	1	0	0	0	0	1	0	0	0	4280	652	23	3	1235	3	DCAF12	9	34125196	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		34125196	107088235	80	54995											
OR13C4	138804	broad.mit.edu	37	chr9	107288722	107288722	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cttaggttttgcatacataaAgaagatggtaccataaaata	17	12	7	5	0	0	2	0	0	0	2	0	2	0	2	1	2	3	3	1	2	9	8			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr9:107288722A>G	uc011lvn.1	-	1	769	c.769T>C	c.(769-771)TTT>CTT	p.F257L		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCATACATAAAGAAGATGGTA	0.468													73	42					0	0	0	0	G	107288722	G	G	107288722	3	3	297	1	0	0	0	0	1	0	0	0	10990	72	3	5	189	5	OR13C4	9	107288722	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	73163526	107288722	33924709	81	54996											
WDR34	89891	broad.mit.edu	37	chr9	131397505	131397505	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacactcagcacctggaagcGgtggctgtgcccaggctcgg	7	6	14	14	2	1	0	1	0	0	0	2	1	1	1	2	5	3	3	2	5	1	0	rs11541003		TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr9:131397505G>A	uc004bvq.1	-	6	971	c.847C>T	c.(847-849)CGC>TGC	p.R283C	WDR34_uc004bvs.1_Missense_Mutation_p.R274C|WDR34_uc004bvr.1_Intron	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	283	WD 2.					cytoplasm				central_nervous_system(2)|skin(1)	3						ACCTGGAAGCGGTGGCTGTGC	0.652											OREG0019522	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	12					0	0	0	0	A	131397505	A	A	131397505	3	1	297	1	0	0	0	0	1	0	0	0	17356	1116	39	1	779	1	WDR34	9	131397505	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	24108783	131397505	9815926	82	54997											
RET	5979	broad.mit.edu	37	chr10	43604533	43604533	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaaccgcaccatgcagctggCggtgctggtcaatgactcag	9	7	13	12	2	2	1	2	1	0	0	2	2	2	1	2	3	4	4	2	3	2	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr10:43604533C>T	uc001jal.2	+	6	1308	c.1118C>T	c.(1117-1119)GCG>GTG	p.A373V	RET_uc001jak.1_Missense_Mutation_p.A373V|RET_uc010qez.1_Missense_Mutation_p.A119V	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	373	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity	p.A373A(1)		thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	ATGCAGCTGGCGGTGCTGGTC	0.622		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				16	36					0	0	0	0	T	43604533	T	T	43604533	3	4	297	1	0	0	0	0	1	0	0	0	13300	768	27	1	1140	1	RET	10	43604533	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		43604533	91930214	83	54998											
CCAR1	55749	broad.mit.edu	37	chr10	70546361	70546361	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctgttaatggcttttgtttAttttgatcaaagtcattgtg	8	21	8	4	0	3	1	2	1	1	0	3	1	3	1	0	1	0	3	0	1	3	8			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr10:70546361A>G	uc001joo.2	+	21	2911	c.2792A>G	c.(2791-2793)TAT>TGT	p.Y931C	CCAR1_uc010qiz.1_Missense_Mutation_p.Y916C|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	931					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						GCTTTTGTTTATTTTGATCAA	0.313													16	31					0	0	0	0	G	70546361	G	G	70546361	3	3	297	1	0	0	0	0	1	0	0	0	2742	449	16	5	2870	5	CCAR1	10	70546361	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	26941828	70546361	64988386	84	54999											
PKP3	11187	broad.mit.edu	37	chr11	399010	399010	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcccgcagccttcaggccGtgcctaggctggtgaagctc	6	7	14	14	2	1	1	1	1	0	0	2	1	1	1	4	4	3	3	4	4	2	2	rs141688536	byFrequency	TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:399010G>A	uc001lpc.2	+	5	1163	c.1087G>A	c.(1087-1089)GTG>ATG	p.V363M		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	363	ARM 2.				cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCTTCAGGCCGTGCCTAGGCT	0.602													11	81					0	0	0	0	A	399010	A	A	399010	3	1	297	1	0	0	0	0	1	0	0	0	12041	1145	40	1	1105	1	PKP3	11	399010	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08		399010	134607506	85	55000											
LRRC56	115399	broad.mit.edu	37	chr11	552187	552187	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctgcagacagctctgactTcctggccttggctgggctca	5	10	11	15	0	2	2	1	1	1	1	3	2	3	2	3	3	2	4	3	3	0	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:552187T>A	uc010qvz.1	+	12	1641	c.1136T>A	c.(1135-1137)TTC>TAC	p.F379Y		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	379										skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGCTCTGACTTCCTGGCCTTG	0.672													17	56					0	0	0	0	A	552187	A	A	552187	3	1	297	1	0	0	0	0	1	0	0	0	9062	1783	62	5	1170	5	LRRC56	11	552187	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08	153177	552187	134454329	86	55001											
PHRF1	57661	broad.mit.edu	37	chr11	611692	611692	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtggccaacctggtgaaggCgtacgtggacaagtacaggc	10	6	16	9	2	0	1	0	1	0	0	0	2	0	2	2	6	3	2	2	6	5	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:611692C>T	uc001lqe.2	+	18	4996	c.4865C>T	c.(4864-4866)GCG>GTG	p.A1622V	PHRF1_uc010qwc.1_Missense_Mutation_p.A1621V|PHRF1_uc010qwd.1_Missense_Mutation_p.A1620V|PHRF1_uc010qwe.1_Missense_Mutation_p.A1618V|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1622							RNA polymerase binding|zinc ion binding				0						CTGGTGAAGGCGTACGTGGAC	0.602													6	48					0	0	0	0	T	611692	T	T	611692	3	4	297	1	0	0	0	0	1	0	0	0	11916	768	27	1	4928	1	PHRF1	11	611692	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	59505	611692	134394824	87	55002											
DCHS1	8642	broad.mit.edu	37	chr11	6654065	6654065	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tgtcttcaggtgcaggaaagGcaggggagttgtcattcaca	10	10	14	7	0	4	0	3	0	1	0	4	2	4	2	0	5	1	3	0	5	1	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:6654065G>A	uc001mem.1	-	6	3088	c.2678C>T	c.(2677-2679)GCC>GTC	p.A893V		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	893	Cadherin 8.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCAGGAAAGGCAGGGGAGTT	0.582													4	30					0	0	0	0	A	6654065	A	A	6654065	3	1	297	1	0	0	0	0	1	0	0	0	4304	1203	42	4	7282	4	DCHS1	11	6654065	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	6042373	6654065	128352451	88	55003											
SWAP70	23075	broad.mit.edu	37	chr11	9769601	9769601	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	agcaagcacttgagcagtacGaggtaatgagacttggccct	12	8	12	9	1	0	2	0	2	0	1	0	4	0	2	1	2	4	5	1	2	3	4	rs141564084	by1000genomes	TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:9769601G>C	uc001mhw.2	+	10	1651	c.1552G>C	c.(1552-1554)GAG>CAG	p.E518Q	SWAP70_uc001mhx.2_Missense_Mutation_p.E460Q	NM_015055	NP_055870	Q9UH65	SWP70_HUMAN	SWAP-70 protein	518	Potential.					cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			ovary(2)|central_nervous_system(1)	3				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		TGAGCAGTACGAGGTAATGAG	0.438													15	44					0	0	0	0	C	9769601	C	C	9769601	3	2	297	1	0	0	0	0	1	0	0	0	15491	1059	37	3	1590	3	SWAP70	11	9769601	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	3115536	9769601	125236915	89	55004											
SAAL1	113174	broad.mit.edu	37	chr11	18113850	18113850	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggaaacaggccatattacCtaaaattcccacacagattt	15	10	5	11	0	0	1	0	0	0	1	1	2	1	2	3	2	2	0	3	2	5	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:18113850C>A	uc001mnq.2	-	4	405	c.355G>T	c.(355-357)GGT>TGT	p.G119C	SAAL1_uc001mnr.2_Missense_Mutation_p.G119C|SAAL1_uc001mns.2_RNA|SAAL1_uc009yhf.2_Missense_Mutation_p.G119C	NM_138421	NP_612430	Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	119					acute-phase response	extracellular region	binding				0						GCCATATTACCTAAAATTCCC	0.308													11	23					7.93312e-07	1.43193e-06	1	0	A	18113850	A	A	18113850	3	1	297	1	0	0	0	0	1	0	0	0	13866	681	24	4	1105	4	SAAL1	11	18113850	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	8344249	18113850	116892666	90	55005											
GYLTL1B	120071	broad.mit.edu	37	chr11	45950253	45950253	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccaagcctggacatctccCgcttccgctccagccccacc	6	7	6	22	2	1	0	0	0	1	0	5	1	4	1	8	1	2	2	8	1	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:45950253C>T	uc001nbv.1	+	14	2134	c.2023C>T	c.(2023-2025)CGC>TGC	p.R675C	GYLTL1B_uc001nbw.1_Missense_Mutation_p.R644C|GYLTL1B_uc001nbx.1_Missense_Mutation_p.R675C|GYLTL1B_uc001nby.1_Missense_Mutation_p.R358C|GYLTL1B_uc001nbz.1_Silent_p.P23P	NM_152312	NP_689525	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	675	Lumenal (Potential).				muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.226)		GGACATCTCCCGCTTCCGCTC	0.632													29	83					0	0	0	0	T	45950253	T	T	45950253	3	4	297	1	0	0	0	0	1	0	0	0	6946	652	23	1	2073	1	GYLTL1B	11	45950253	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	27836403	45950253	89056263	91	55006											
CKAP5	9793	broad.mit.edu	37	chr11	46765612	46765612	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attctctccagtctttttttCaagtcgtctatgttagctgt	6	20	6	9	1	4	0	1	0	3	0	7	0	5	0	1	0	1	2	1	0	3	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:46765612C>G	uc001ndi.1	-	44	6170	c.6060G>C	c.(6058-6060)TTG>TTC	p.L2020F	CKAP5_uc009ylg.1_Missense_Mutation_p.L1913F|CKAP5_uc001ndj.1_Missense_Mutation_p.L1960F|CKAP5_uc001ndh.1_Missense_Mutation_p.L949F	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	2020					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						GTCTTTTTTTCAAGTCGTCTA	0.493													24	65					0	0	0	0	G	46765612	G	G	46765612	3	3	297	1	0	0	0	0	1	0	0	0	3460	825	29	2	42	2	CKAP5	11	46765612	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	815359	46765612	88240904	92	55007											
OR4C15	81309	broad.mit.edu	37	chr11	55322294	55322294	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgattgtcctcacagccaTggcctatgatcgttatgtgg	7	13	12	9	1	1	2	1	2	0	0	3	2	2	2	3	3	1	1	3	3	2	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:55322294T>A	uc010rig.1	+	1	512	c.512T>A	c.(511-513)ATG>AAG	p.M171K		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTCACAGCCATGGCCTATGAT	0.498										HNSCC(20;0.049)			77	76					0	0	0	0	A	55322294	A	A	55322294	3	1	297	1	0	0	0	0	1	0	0	0	11102	1464	51	5	514	5	OR4C15	11	55322294	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08	8556682	55322294	79684222	93	55008											
OR9G4	283189	broad.mit.edu	37	chr11	56511135	56511135	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtttcctgacaaggttatCaaatagagcatcagaaacac	16	10	7	8	0	2	3	2	1	0	2	3	3	3	3	1	1	2	3	1	1	5	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:56511135C>T	uc010rjo.1	-	1	153	c.153G>A	c.(151-153)TTG>TTA	p.L51L		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	51	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ACAAGGTTATCAAATAGAGCA	0.413													15	48					0	0	0	0	T	56511135	T	T	56511135	2	4	297	1	0	0	0	0	0	0	0	1	11305	825	29	2		2	OR9G4	11	56511135	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	1188841	56511135	78495381	94	55009											
SLC43A1	8501	broad.mit.edu	37	chr11	57259321	57259321	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gggggagcagaggctcttgcGtaaggggacagaccctgggg	8	5	20	8	1	1	2	0	0	1	2	1	4	1	4	1	7	2	3	1	7	1	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:57259321G>A	uc001nkk.2	-	9	1004	c.886C>T	c.(886-888)CGC>TGC	p.R296C	SLC43A1_uc001nkl.2_Missense_Mutation_p.R296C	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	296					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						AGGCTCTTGCGTAAGGGGACA	0.607											OREG0020651	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	46					0	0	0	0	A	57259321	A	A	57259321	3	1	297	1	0	0	0	0	1	0	0	0	14696	1145	40	1	821	1	SLC43A1	11	57259321	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	748186	57259321	77747195	95	55010											
SMTNL1	219537	broad.mit.edu	37	chr11	57310254	57310254	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggccatcaatgaggggcctCccactgagtcaggaaagcag	12	5	13	11	0	2	2	2	2	0	0	3	3	3	3	3	4	1	1	3	4	2	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:57310254C>T	uc009ymh.1	+	2	193	c.193C>T	c.(193-195)CCC>TCC	p.P65S		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	47										ovary(1)	1						TGAGGGGCCTCCCACTGAGTC	0.577													10	17					0	0	0	0	T	57310254	T	T	57310254	3	4	297	1	0	0	0	0	1	0	0	0	14879	855	30	2	199	2	SMTNL1	11	57310254	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	50933	57310254	77696262	96	55011											
OR1S1	219959	broad.mit.edu	37	chr11	57982857	57982864	+	Frame_Shift_Del	DEL	TTGTGGGT	-	-																															caatgagcttgtgttgtttaTtgtgggtttatcagttatca																										TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:57982857_57982864delTTGTGGGT	uc010rkc.1	+	1	641_648	c.641_648delTTGTGGGT	c.(640-648)ATTGTGGGTfs	p.I214fs		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	214_216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				GTGTTGTTTATTGTGGGTTTATCAGTTA	0.438													---	---	---								-	57982864	-	-	57982857	7	5	297	1	0	1	0	1	0	0	0	0	11026	1493	52	0	643	0	OR1S1	11	57982857	Frame_Shift_Del	DEL	TTGTGGGT	TCGA-HD-7229-01A-11D-2012-08	672603	57982857	77023659	97	55012											
OR5B3	441608	broad.mit.edu	37	chr11	58170743	58170743	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ggagacaggaatcccagaatAtcaatacaataattcccagg	17	7	8	9	0	1	2	1	0	0	2	3	4	3	3	2	3	1	0	2	3	7	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:58170743A>G	uc010rkf.1	-	1	140	c.140T>C	c.(139-141)ATA>ACA	p.I47T		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	47	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				ATCCCAGAATATCAATACAAT	0.423													3	101					0	0	0	0	G	58170743	G	G	58170743	3	3	297	1	0	0	0	0	1	0	0	0	11206	449	16	5	806	5	OR5B3	11	58170743	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	187886	58170743	76835773	98	55013											
PLCB3	5331	broad.mit.edu	37	chr11	64033975	64033975	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcccgtgcagggaactgaCggagattaaccgtcggcaca	10	6	13	12	4	0	2	0	1	0	1	2	4	1	3	2	3	3	3	2	3	2	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:64033975C>G	uc001nzb.2	+	29	3365	c.3365C>G	c.(3364-3366)ACG>AGG	p.T1122R	PLCB3_uc009ypg.1_Missense_Mutation_p.T1122R|PLCB3_uc009yph.1_Missense_Mutation_p.T1055R|PLCB3_uc009ypi.2_Missense_Mutation_p.T1122R	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1122					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						AGGGAACTGACGGAGATTAAC	0.652													8	49					0	0	0	0	G	64033975	G	G	64033975	3	3	297	1	0	0	0	0	1	0	0	0	12084	536	19	3	3479	3	PLCB3	11	64033975	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	5863232	64033975	70972541	99	55014											
CCDC88B	283234	broad.mit.edu	37	chr11	64109596	64109596	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccaaggctcagctgcggcGtctgcggcaggagctgtgag	6	6	17	12	4	2	1	1	1	1	0	2	2	2	2	1	4	4	4	1	4	1	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:64109596G>C	uc001nzy.2	+	8	850	c.806G>C	c.(805-807)CGT>CCT	p.R269P	CCDC88B_uc009ypo.1_Missense_Mutation_p.R266P|CCDC88B_uc001nzz.1_5'Flank	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	269	Potential.				microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						CAGCTGCGGCGTCTGCGGCAG	0.682													11	25					0	0	0	0	C	64109596	C	C	64109596	3	2	297	1	0	0	0	0	1	0	0	0	2877	1145	40	3	836	3	CCDC88B	11	64109596	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	75621	64109596	70896920	100	55015											
KAT5	10524	broad.mit.edu	37	chr11	65486406	65486406	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctccactctgcagtacctcaAtctcatcaactactacaagg	12	10	4	15	0	4	0	3	0	2	0	6	0	5	0	2	1	5	2	2	1	6	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:65486406A>C	uc001ofi.2	+	13	1638	c.1388A>C	c.(1387-1389)AAT>ACT	p.N463T	KAT5_uc001ofj.2_Missense_Mutation_p.N411T|KAT5_uc001ofk.2_Missense_Mutation_p.N496T|KAT5_uc010roo.1_Missense_Mutation_p.N444T|KAT5_uc001ofl.2_Missense_Mutation_p.N252T|RNASEH2C_uc001ofm.2_RNA|RNASEH2C_uc001ofn.2_3'UTR	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	463					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						CAGTACCTCAATCTCATCAAC	0.532													11	36					0	0	0	0	C	65486406	C	C	65486406	3	2	297	1	0	0	0	0	1	0	0	0	8022	101	4	5	1533	5	KAT5	11	65486406	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	1376810	65486406	69520110	101	55016											
DKFZp761E198	91056	broad.mit.edu	37	chr11	65547050	65547050	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctgcggcttgaagagtgccGgtggctgtccctgcagaccc	5	8	15	13	2	0	3	0	1	0	2	1	3	1	3	3	3	3	4	3	3	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:65547050G>A	uc001ofo.3	-	1	773	c.743C>T	c.(742-744)CCG>CTG	p.P248L		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	248	Leu-rich.						protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		GAAGAGTGCCGGTGGCTGTCC	0.647													5	24					0	0	0	0	A	65547050	A	A	65547050	3	1	297	1	0	0	0	0	1	0	0	0	4565	1116	39	1	1726	1	DKFZp761E198	11	65547050	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	60644	65547050	69459466	102	55017											
DKFZp761E198	91056	broad.mit.edu	37	chr11	65547195	65547195	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcagggctgtgctctcGtgctgtaaggctacgctccc	4	11	11	15	2	2	0	1	0	1	0	5	0	4	0	2	2	3	6	2	2	2	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:65547195G>A	uc001ofo.3	-	1	628	c.598C>T	c.(598-600)CGA>TGA	p.R200*		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	200	Leu-rich.						protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		CTGTGCTCTCGTGCTGTAAGG	0.667													8	108					0	0	0	0	A	65547195	A	A	65547195	4	1	297	1	0	0	0	0	0	1	0	0	4565	1153	40	1	1871	1	DKFZp761E198	11	65547195	Nonsense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	145	65547195	69459321	103	55018											
ADRBK1	156	broad.mit.edu	37	chr11	67048572	67048572	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgcccctcagctgaccatGaatgacttcagcgtgcatcg	8	9	10	14	2	2	3	2	3	0	0	3	3	2	3	3	0	4	3	3	0	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:67048572G>C	uc009yrn.1	+	8	830	c.564G>C	c.(562-564)ATG>ATC	p.M188I	ADRBK1_uc009yrm.1_Missense_Mutation_p.M188I	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	188	N-terminal.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	AGCTGACCATGAATGACTTCA	0.662													22	64					0	0	0	0	C	67048572	C	C	67048572	3	2	297	1	0	0	0	0	1	0	0	0	343	1290	45	2	594	2	ADRBK1	11	67048572	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	1501377	67048572	67957944	104	55019											
C11orf30	56946	broad.mit.edu	37	chr11	76255467	76255467	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagaaacttagccagcccccGctggaacagactcagctgca	12	5	9	15	1	1	2	1	0	0	2	1	3	1	3	3	1	6	3	3	1	3	1	rs149047897		TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:76255467G>A	uc001oxl.2	+	19	3017	c.2874G>A	c.(2872-2874)CCG>CCA	p.P958P	C11orf30_uc001oxm.2_Silent_p.P860P|C11orf30_uc010rsb.1_Silent_p.P973P|C11orf30_uc010rsc.1_Silent_p.P959P|C11orf30_uc001oxn.2_Silent_p.P959P|C11orf30_uc010rsd.1_Silent_p.P867P|C11orf30_uc001oxo.1_Silent_p.P312P|C11orf30_uc010rse.1_Silent_p.P205P|C11orf30_uc001oxp.2_Silent_p.P58P	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	958	Gln-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						GCCAGCCCCCGCTGGAACAGA	0.517													24	80					0	0	0	0	A	76255467	A	A	76255467	2	1	297	1	0	0	0	0	0	0	0	1	1642	1074	38	1		1	C11orf30	11	76255467	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	9206895	76255467	58751049	105	55020											
ME3	10873	broad.mit.edu	37	chr11	86270821	86270821	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcagggcgggattaggccGtggattccaagctgcagcct	9	7	15	10	2	0	0	0	0	0	0	1	2	1	2	3	4	4	3	3	4	3	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:86270821G>C	uc001pbz.2	-	2	482	c.228C>G	c.(226-228)CAC>CAG	p.H76Q	ME3_uc001pca.2_Missense_Mutation_p.H76Q|ME3_uc009yvk.2_Missense_Mutation_p.H76Q|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	76					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	GGATTAGGCCGTGGATTCCAA	0.522													28	106					0	0	0	0	C	86270821	C	C	86270821	3	2	297	1	0	0	0	0	1	0	0	0	9472	1136	40	3	1638	3	ME3	11	86270821	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	10015354	86270821	48735695	106	55021											
MTMR2	8898	broad.mit.edu	37	chr11	95569429	95569429	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcccatagagaggattagtGaagtcttccagctggctgtt	9	12	11	9	0	1	2	0	1	1	1	3	4	3	3	2	2	1	3	2	2	3	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:95569429G>A	uc001pfu.2	-	14	1906	c.1653C>T	c.(1651-1653)TTC>TTT	p.F551F	MTMR2_uc001pfv.2_Silent_p.F479F|MTMR2_uc001pfs.2_Silent_p.F479F|MTMR2_uc001pft.2_Silent_p.F479F	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	551	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GAGGATTAGTGAAGTCTTCCA	0.443													16	106					0	0	0	0	A	95569429	A	A	95569429	2	1	297	1	0	0	0	0	0	0	0	1	9997	1281	45	2		2	MTMR2	11	95569429	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	9298608	95569429	39437087	107	55022											
DDI1	414301	broad.mit.edu	37	chr11	103908268	103908268	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggcccccgagagttttggaCaagtgacgatgctctacatt	10	10	11	10	2	1	2	0	1	1	1	1	5	1	3	2	2	2	2	2	2	2	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:103908268C>A	uc001phr.2	+	1	961	c.718C>A	c.(718-720)CAA>AAA	p.Q240K	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	240					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GAGTTTTGGACAAGTGACGAT	0.478													33	179					5.8336e-16	1.09684e-15	1	0	A	103908268	A	A	103908268	3	1	297	1	0	0	0	0	1	0	0	0	4345	479	17	4	720	4	DDI1	11	103908268	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	8338839	103908268	31098248	108	55023											
GUCY1A2	2977	broad.mit.edu	37	chr11	106888551	106888551	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgcctccggcgctgcaccctCctggccccggcagtggcagc	3	5	13	20	4	0	0	0	0	0	0	2	0	2	0	6	4	2	4	6	4	0	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:106888551C>G	uc001pjg.1	-	1	621	c.231G>C	c.(229-231)AGG>AGC	p.R77S	GUCY1A2_uc010rvo.1_Missense_Mutation_p.R77S|GUCY1A2_uc009yxn.1_Missense_Mutation_p.R77S	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	77					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GCTGCACCCTCCTGGCCCcgg	0.498													4	9					0	0	0	0	G	106888551	G	G	106888551	3	3	297	1	0	0	0	0	1	0	0	0	6932	854	30	2	1999	2	GUCY1A2	11	106888551	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	2980283	106888551	28117965	109	55024											
DLAT	1737	broad.mit.edu	37	chr11	111899661	111899661	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtagctcatatccccctCacatgcaggtgaggctcagc	8	9	10	14	0	3	1	3	1	0	0	4	1	4	1	2	3	3	4	2	3	2	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:111899661C>G	uc001pmo.2	+	4	1311	c.652C>G	c.(652-654)CAC>GAC	p.H218D	DLAT_uc009yyk.1_Missense_Mutation_p.H218D|DLAT_uc010rwr.1_Intron	NM_001931	NP_001922	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase precursor	218					glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding				0		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	ATATCCCCCTCACATGCAGGT	0.517													33	87					0	0	0	0	G	111899661	G	G	111899661	3	3	297	1	0	0	0	0	1	0	0	0	4571	826	29	2	666	2	DLAT	11	111899661	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	5011110	111899661	23106855	110	55025											
HYOU1	10525	broad.mit.edu	37	chr11	118922623	118922623	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtacactgcccccatggCggctgcttcatctgcattga	6	11	10	14	1	2	1	1	1	1	0	2	1	2	1	2	3	4	4	2	3	1	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr11:118922623C>T	uc001puu.2	-	12	1439	c.1246G>A	c.(1246-1248)GCC>ACC	p.A416T	HYOU1_uc001put.2_Missense_Mutation_p.A381T|HYOU1_uc010ryu.1_Missense_Mutation_p.A436T|HYOU1_uc010ryv.1_Missense_Mutation_p.A305T|HYOU1_uc001pux.3_Missense_Mutation_p.A416T|HYOU1_uc010ryw.1_RNA|HYOU1_uc001puw.1_Missense_Mutation_p.A416T	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	416						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		GCCCCCATGGCGGCTGCTTCA	0.582													56	47					0	0	0	0	T	118922623	T	T	118922623	3	4	297	1	0	0	0	0	1	0	0	0	7509	768	27	1	1813	1	HYOU1	11	118922623	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	7022962	118922623	16083893	111	55026											
TUBA1B	10376	broad.mit.edu	37	chr12	49523424	49523424	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggccatcgggctggatgcCgtgttccaggcagtagagct	6	9	15	11	2	0	1	0	0	0	1	2	2	1	2	3	4	2	5	3	4	1	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr12:49523424C>G	uc001rtm.2	-	2	306	c.85G>C	c.(85-87)GGC>CGC	p.G29R	TUBA1B_uc001rto.2_Intron|TUBA1B_uc001rtk.2_5'UTR|TUBA1B_uc001rtl.2_5'UTR|TUBA1B_uc001rtn.2_5'UTR	NM_006082	NP_006073	P68363	TBA1B_HUMAN	tubulin, alpha, ubiquitous	29					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding				0						GGCTGGATGCCGTGTTCCAGG	0.577													13	88					0	0	0	0	G	49523424	G	G	49523424	3	3	297	1	0	0	0	0	1	0	0	0	16812	652	23	3	1282	3	TUBA1B	12	49523424	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		49523424	84328471	112	55027											
KRT1	3848	broad.mit.edu	37	chr12	53069099	53069099	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctccagagctcccgccgcCagagccccggccgccagagc	6	2	12	21	4	0	3	0	0	0	3	2	3	2	3	9	1	3	1	9	1	0	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr12:53069099C>A	uc001sau.1	-	9	1872	c.1813G>T	c.(1813-1815)GGC>TGC	p.G605C	KRT1_uc001sav.1_Missense_Mutation_p.G598C	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	605	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						CTCCCGCCGCCAGAGCCCCGg	0.348													7	53					2.23348e-06	3.99152e-06	1	0	A	53069099	A	A	53069099	3	1	297	1	0	0	0	0	1	0	0	0	8486	594	21	4	125	4	KRT1	12	53069099	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	3545675	53069099	80782796	113	55028											
KRT4	3851	broad.mit.edu	37	chr12	53208022	53208022	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcacaagcccatccttccCgcacccgttgagcatgtcac	8	8	8	17	2	1	1	1	1	0	0	3	1	3	1	4	1	2	4	4	1	1	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr12:53208022C>T	uc001saz.2	-	1	314	c.43G>A	c.(43-45)GGG>AGG	p.G15R		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	Error:Variant_position_missing_in_B4DRS2_after_alignment						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						CCATCCTTCCCGCACCCGTTG	0.527													33	76					0	0	0	0	T	53208022	T	T	53208022	3	4	297	1	0	0	0	0	1	0	0	0	8516	652	23	1	1777	1	KRT4	12	53208022	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	138923	53208022	80643873	114	55029											
PRIM1	5557	broad.mit.edu	37	chr12	57145981	57145981	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cattcctcgcctccatcaccTccaccgtagttgagccagcg	7	9	7	18	3	1	1	1	1	0	0	5	1	4	1	7	0	2	2	7	0	1	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr12:57145981T>A	uc001smd.2	-	1	166	c.102A>T	c.(100-102)GGA>GGT	p.G34G	PRIM1_uc001sme.1_RNA|PRIM1_uc009zoz.1_RNA|PRIM1_uc001smf.2_Silent_p.G34G	NM_000946	NP_000937	P49642	PRI1_HUMAN	DNA primase polypeptide 1	34					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	DNA primase activity|metal ion binding				0						CTCCATCACCTCCACCGTAGT	0.473													9	13					0	0	0	0	A	57145981	A	A	57145981	2	1	297	1	0	0	0	0	0	0	0	1	12552	1565	54	5		5	PRIM1	12	57145981	Silent	SNP	T	TCGA-HD-7229-01A-11D-2012-08	3937959	57145981	76705914	115	55030											
PPFIA2	8499	broad.mit.edu	37	chr12	81657084	81657084	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ctggtaatgtttctgaggacCcaggcatcatgctgattcca	9	12	10	10	0	2	2	1	2	1	0	3	3	3	3	2	3	1	4	2	3	1	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr12:81657084C>A	uc001szo.1	-	31	3802	c.3641G>T	c.(3640-3642)GGG>GTG	p.G1214V	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	1113										ovary(3)|lung(2)|pancreas(1)	6						TTCTGAGGACCCAGGCATCAT	0.453													11	27					3.86212e-05	6.76808e-05	1	0	A	81657084	A	A	81657084	3	1	297	1	0	0	0	0	1	0	0	0	12365	623	22	4	140	4	PPFIA2	12	81657084	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	24511103	81657084	52194811	116	55031											
TMTC3	160418	broad.mit.edu	37	chr12	88560138	88560138	+	Frame_Shift_Del	DEL	C	-	-																															cagctgctgtaagcccaactCctacaaggcaactaactttt																										TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr12:88560138delC	uc001tau.2	+	7	1049	c.829delC	c.(829-831)CCTfs	p.P277fs	TMTC3_uc009zsm.2_RNA	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	277						integral to membrane	binding			skin(1)	1						AAGCCCAACTCCTACAAGGCA	0.348													---	---	---								-	88560138	-	-	88560138	7	5	297	1	0	1	0	1	0	0	0	0	16328	855	30	0	851	0	TMTC3	12	88560138	Frame_Shift_Del	DEL	C	TCGA-HD-7229-01A-11D-2012-08	6903054	88560138	45291757	117	55032											
SLC25A3	5250	broad.mit.edu	37	chr12	98987826	98987826	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacatctgcagctggtgcacGatggtctcggggacctccgc	6	8	13	14	3	2	0	0	0	2	0	4	2	3	1	2	4	3	3	2	4	0	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr12:98987826G>C	uc001tfo.2	+	2	190	c.70G>C	c.(70-72)GAT>CAT	p.D24H	SLC25A3_uc001tfm.2_Missense_Mutation_p.D24H|SLC25A3_uc001tfn.2_Missense_Mutation_p.D24H|SLC25A3_uc001tfp.2_Missense_Mutation_p.D24H|SLC25A3_uc001tfq.2_5'UTR|SLC25A3_uc001tfr.2_Missense_Mutation_p.D24H|SLC25A3_uc001tfs.2_5'UTR|SLC25A3_uc009ztn.2_Missense_Mutation_p.D24H|SLC25A3_uc001tft.2_Missense_Mutation_p.D24H	NM_005888	NP_005879	Q00325	MPCP_HUMAN	solute carrier family 25 member 3 isoform a	24					generation of precursor metabolites and energy	integral to plasma membrane|mitochondrial inner membrane	phosphate carrier activity|symporter activity				0		Lung NSC(355;4.08e-05)|Breast(359;0.00191)|Colorectal(145;0.00205)|Myeloproliferative disorder(1001;0.0255)		GBM - Glioblastoma multiforme(134;1.36e-23)|BRCA - Breast invasive adenocarcinoma(302;0.000115)		GCTGGTGCACGATGGTCTCGG	0.687													9	22					0	0	0	0	C	98987826	C	C	98987826	3	2	297	1	0	0	0	0	1	0	0	0	14557	1058	37	3	72	3	SLC25A3	12	98987826	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	10427688	98987826	34864069	118	55033											
ATXN2	6311	broad.mit.edu	37	chr12	111993687	111993687	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaacattaaagttactcacCgtagactgaggcagtccttt	12	12	8	9	1	1	2	1	1	0	1	2	2	2	2	2	1	2	4	2	1	5	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr12:111993687C>A	uc001tsj.2	-	2	930	c.768G>T	c.(766-768)ACG>ACT	p.T256T	ATXN2_uc001tsh.2_5'UTR|ATXN2_uc001tsi.2_Intron|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_5'UTR	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	256					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						AGTTACTCACCGTAGACTGAG	0.328													6	19					3.59834e-05	6.36764e-05	1	0	A	111993687	A	A	111993687	2	1	297	1	0	0	0	0	0	0	0	1	1213	666	23	3		3	ATXN2	12	111993687	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	13005861	111993687	21858208	119	55034											
SLC24A6	80024	broad.mit.edu	37	chr12	113744331	113744331	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgccaaagcaggcggagaaCgccatccgtgggtagccctg	9	4	14	14	4	0	1	0	0	0	1	1	2	1	1	5	3	3	2	5	3	3	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr12:113744331C>G	uc001tvc.2	-	14	1671	c.1461G>C	c.(1459-1461)GCG>GCC	p.A487A	SLC24A6_uc001tuz.2_Silent_p.A192A|SLC24A6_uc001tva.2_RNA|SLC24A6_uc001tvb.2_Silent_p.A225A	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	487	Extracellular (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						AGGCGGAGAACGCCATCCGTG	0.602													3	38					0	0	0	0	G	113744331	G	G	113744331	2	3	297	1	0	0	0	0	0	0	0	1	14534	523	19	3		3	SLC24A6	12	113744331	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	1750644	113744331	20107564	120	55035											
KSR2	283455	broad.mit.edu	37	chr12	117923489	117923489	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggaatagagcgtccgtccctTacagaggctgaaaagcaaaa	15	6	11	9	2	0	3	0	1	0	2	2	4	2	4	2	2	3	2	2	2	7	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr12:117923489T>C	uc001two.2	-	15	2195	c.2140A>G	c.(2140-2142)AAG>GAG	p.K714E		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	743	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTCCGTCCCTTACAGAGGCTG	0.443													11	48					0	0	0	0	C	117923489	C	C	117923489	3	2	297	1	0	0	0	0	1	0	0	0	8622	1763	61	5	649	5	KSR2	12	117923489	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08	4179158	117923489	15928406	121	55036											
POSTN	10631	broad.mit.edu	37	chr13	38164592	38164592	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatctcctccctcagttttgAggcgtcagaatagcgctgcg	7	11	11	12	3	3	2	2	1	1	1	5	3	4	2	2	1	2	2	2	1	2	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr13:38164592A>G	uc001uwo.3	-	4	476	c.358T>C	c.(358-360)TCA>CCA	p.S120P	POSTN_uc001uwp.3_Missense_Mutation_p.S120P|POSTN_uc001uwr.2_Missense_Mutation_p.S120P|POSTN_uc001uwq.2_Missense_Mutation_p.S120P|POSTN_uc010teu.1_Missense_Mutation_p.S120P|POSTN_uc010tev.1_Missense_Mutation_p.S120P|POSTN_uc010tew.1_Missense_Mutation_p.S120P|POSTN_uc010tex.1_Missense_Mutation_p.S35P	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	120	FAS1 1.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CTCAGTTTTGAGGCGTCAGAA	0.448													8	26					0	0	0	0	G	38164592	G	G	38164592	3	3	297	1	0	0	0	0	1	0	0	0	12314	304	11	5	2232	5	POSTN	13	38164592	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08		38164592	77005286	122	55037											
KIAA0564	23078	broad.mit.edu	37	chr13	42393507	42393507	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgattctgaaggagggatgGataggaaaaatggatctaaa	17	9	13	2	0	2	2	0	2	2	0	2	7	2	7	0	5	0	0	0	5	6	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr13:42393507G>A	uc001uyj.2	-	15	1786	c.1716C>T	c.(1714-1716)ATC>ATT	p.I572I	KIAA0564_uc001uyk.2_Silent_p.I572I	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	572						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		AGGAGGGATGGATAGGAAAAA	0.378													11	30					0	0	0	0	A	42393507	A	A	42393507	2	1	297	1	0	0	0	0	0	0	0	1	8224	1164	41	2		2	KIAA0564	13	42393507	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	4228915	42393507	72776371	123	55038											
PCDH8	5100	broad.mit.edu	37	chr13	53422221	53422221	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tctacctccacgtgcaccagCcggaactgctcctgcgagaa	9	7	9	16	3	1	1	0	0	1	1	3	3	3	2	5	1	6	2	5	1	3	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr13:53422221C>T	uc001vhi.2	-	1	554	c.351G>A	c.(349-351)CGG>CGA	p.R117R	PCDH8_uc001vhj.2_Silent_p.R117R	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	117	Extracellular (Potential).|Cadherin 1.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CGTGCACCAGCCGGAACTGCT	0.706													26	47					0	0	0	0	T	53422221	T	T	53422221	2	4	297	1	0	0	0	0	0	0	0	1	11571	726	26	4		4	PCDH8	13	53422221	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	11028714	53422221	61747657	124	55039											
PCDH9	5101	broad.mit.edu	37	chr13	67801103	67801103	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttcatctgtggcactaatAgttgttaagtataacccacg	11	14	7	9	1	3	0	1	0	2	0	3	0	3	0	1	1	1	4	1	1	5	7			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr13:67801103A>T	uc001vik.2	-	2	2162	c.1470T>A	c.(1468-1470)ACT>ACA	p.T490T	PCDH9_uc001vil.2_Silent_p.T490T|PCDH9_uc010thl.1_Silent_p.T490T|PCDH9_uc001vin.3_Silent_p.T490T	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	490	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TGGCACTAATAGTTGTTAAGT	0.413													27	62					0	0	0	0	T	67801103	T	T	67801103	2	4	297	1	0	0	0	0	0	0	0	1	11572	407	15	5		5	PCDH9	13	67801103	Silent	SNP	A	TCGA-HD-7229-01A-11D-2012-08	14378882	67801103	47368775	125	55040											
FARP1	10160	broad.mit.edu	37	chr13	99061621	99061621	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggcagtcctcacctttccGagctgtctgtgaactcgcag	6	11	10	14	2	2	1	1	1	1	0	5	2	4	1	3	1	2	3	3	1	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr13:99061621G>T	uc001vnj.2	+	14	1780	c.1444G>T	c.(1444-1446)GAG>TAG	p.E482*	FARP1_uc001vnh.2_Nonsense_Mutation_p.E482*	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	482					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TCACCTTTCCGAGCTGTCTGT	0.522													4	73					0.000602214	0.00104019	1	0	T	99061621	T	T	99061621	4	4	297	1	0	0	0	0	0	1	0	0	5708	1059	37	3	1717	3	FARP1	13	99061621	Nonsense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	31260518	99061621	16108257	126	55041											
COL4A1	1282	broad.mit.edu	37	chr13	110831718	110831718	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccgggtgtgccaggaatgccGggaagacctggcaaaccttt	9	7	14	11	2	0	1	0	0	0	1	0	3	0	3	5	4	3	1	5	4	3	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr13:110831718G>A	uc001vqw.3	-	30	2366	c.2244C>T	c.(2242-2244)CCC>CCT	p.P748P	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	748	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CAGGAATGCCGGGAAGACCTG	0.562													19	70					0	0	0	0	A	110831718	A	A	110831718	2	1	297	1	0	0	0	0	0	0	0	1	3704	1103	39	1		1	COL4A1	13	110831718	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	11770097	110831718	4338160	127	55042											
COL4A2	1284	broad.mit.edu	37	chr13	111090996	111090996	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagggagaagaaggaatcaTgggctttcctggactgaggg	12	7	17	5	0	1	3	1	1	0	2	2	7	2	5	1	5	0	1	1	5	4	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr13:111090996T>A	uc001vqx.2	+	15	1182	c.893T>A	c.(892-894)ATG>AAG	p.M298K		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	298	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GAAGGAATCATGGGCTTTCCT	0.463													31	76					0	0	0	0	A	111090996	A	A	111090996	3	1	297	1	0	0	0	0	1	0	0	0	3705	1464	51	5	947	5	COL4A2	13	111090996	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08	259278	111090996	4078882	128	55043											
TUBGCP3	10426	broad.mit.edu	37	chr13	113210456	113210456	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtggcttgtgaagaaggctGatttgcagttaaagtccatg	11	12	13	5	0	0	3	0	2	0	1	1	3	1	3	1	2	1	4	1	2	4	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr13:113210456G>A	uc001vse.1	-	6	818	c.631C>T	c.(631-633)CAG>TAG	p.Q211*	TUBGCP3_uc010tjq.1_Nonsense_Mutation_p.Q201*|TUBGCP3_uc001vsf.2_Nonsense_Mutation_p.Q211*|TUBGCP3_uc001vsg.1_Nonsense_Mutation_p.Q211*	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	211					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					GAAGAAGGCTGATTTGCAGTT	0.493													18	42					0	0	0	0	A	113210456	A	A	113210456	4	1	297	1	0	0	0	0	0	1	0	0	16835	1299	45	2	2160	2	TUBGCP3	13	113210456	Nonsense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	2119460	113210456	1959422	129	55044											
TMEM90A	646658	broad.mit.edu	37	chr14	74876129	74876129	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcagcttggccaggtcCtgtgggctgctctggaggcc	3	10	15	13	0	2	0	0	0	2	0	3	1	3	1	3	5	3	4	3	5	0	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr14:74876129C>T	uc001xpx.2	-	2	567	c.319G>A	c.(319-321)GGA>AGA	p.G107R		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	107					response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		TGGCCAGGTCCTGTGGGCTGC	0.617													32	66					0	0	0	0	T	74876129	T	T	74876129	3	4	297	1	0	0	0	0	1	0	0	0	16284	690	24	4	409	4	TMEM90A	14	74876129	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		74876129	32473411	130	55045											
MTA1	9112	broad.mit.edu	37	chr14	105936520	105936520	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggccaccgccacctgcgcccGtcaacgacgagcccatcgtc	7	4	10	20	6	1	0	1	0	0	0	3	2	1	0	6	1	3	0	6	1	1	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr14:105936520G>A	uc001yqx.2	+	21	2303	c.2116G>A	c.(2116-2118)GTC>ATC	p.V706I	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Missense_Mutation_p.V471I|CRIP2_uc010tyr.1_5'Flank|CRIP2_uc001yrc.2_5'Flank	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	706					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		ACCTGCGCCCGTCAACGACGA	0.507													10	22					0	0	0	0	A	105936520	A	A	105936520	3	1	297	1	0	0	0	0	1	0	0	0	9961	1145	40	1	2198	1	MTA1	14	105936520	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	31060391	105936520	1413020	131	55046											
GABRB3	2562	broad.mit.edu	37	chr15	26828523	26828523	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgctcgtccagggggtatCtcctgaggtccatcatgcat	6	12	11	12	1	3	1	1	1	2	0	7	1	5	1	3	3	2	3	3	3	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr15:26828523C>T	uc001zaz.2	-	5	642	c.500G>A	c.(499-501)AGA>AAA	p.R167K	GABRB3_uc010uae.1_Missense_Mutation_p.R82K|GABRB3_uc001zba.2_Missense_Mutation_p.R167K|GABRB3_uc001zbb.2_Missense_Mutation_p.R223K	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	167	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAGGGGGTATCTCCTGAGGTC	0.453													21	55					0	0	0	0	T	26828523	T	T	26828523	3	4	297	1	0	0	0	0	1	0	0	0	6202	913	32	2	941	2	GABRB3	15	26828523	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		26828523	75702869	132	55047											
VPS39	23339	broad.mit.edu	37	chr15	42457994	42457994	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtggcagagactccacttcCgggagatcttcagtaaatat	11	10	10	10	2	2	2	1	0	1	2	4	4	4	2	2	2	0	2	2	2	3	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr15:42457994C>T	uc001zpd.2	-	18	1885	c.1734G>A	c.(1732-1734)CCG>CCA	p.P578P	VPS39_uc001zpc.2_Silent_p.P567P|VPS39_uc001zpb.2_5'UTR	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	578					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		ACTCCACTTCCGGGAGATCTT	0.473													8	40					0	0	0	0	T	42457994	T	T	42457994	2	4	297	1	0	0	0	0	0	0	0	1	17277	639	23	1		1	VPS39	15	42457994	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	15629471	42457994	60073398	133	55048											
MYO5A	4644	broad.mit.edu	37	chr15	52672101	52672101	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgcactgccctcttctcatCaaacctacaaataaaaatca	15	10	2	14	0	4	0	3	0	2	0	5	0	4	0	2	0	4	1	2	0	6	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr15:52672101C>G	uc002aby.2	-	17	2261	c.2017G>C	c.(2017-2019)GAT>CAT	p.D673H	MYO5A_uc002abx.3_Missense_Mutation_p.D673H|MYO5A_uc010uge.1_Missense_Mutation_p.D542H	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	673	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTCTTCTCATCAAACCTACAA	0.493													18	53					0	0	0	0	G	52672101	G	G	52672101	3	3	297	1	0	0	0	0	1	0	0	0	10131	826	29	2	3650	2	MYO5A	15	52672101	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	10214107	52672101	49859291	134	55049											
DAPK2	23604	broad.mit.edu	37	chr15	64204146	64204146	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aggtgcaccttcttcatcagCgagcgggtgaggtggttgca	7	10	15	9	2	3	1	2	1	1	0	3	2	3	1	1	4	4	3	1	4	0	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr15:64204146C>T	uc002amr.2	-	11	1024	c.993G>A	c.(991-993)TCG>TCA	p.S331S	DAPK2_uc010uim.1_RNA	NM_014326	NP_055141	Q9UIK4	DAPK2_HUMAN	death-associated kinase 2	331	Calmodulin-binding.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			stomach(1)|central_nervous_system(1)	2				LUAD - Lung adenocarcinoma(2;0.215)		TCTTCATCAGCGAGCGGGTGA	0.577													9	22					0	0	0	0	T	64204146	T	T	64204146	2	4	297	1	0	0	0	0	0	0	0	1	4253	755	27	1		1	DAPK2	15	64204146	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	11532045	64204146	38327246	135	55050											
HCN4	10021	broad.mit.edu	37	chr15	73616247	73616247	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagttgaagacgccggagttGaggtcgtgctggactttgtg	7	12	16	6	3	0	3	0	2	0	1	1	5	0	5	1	3	1	3	1	3	2	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr15:73616247G>C	uc002avp.2	-	8	3181	c.2187C>G	c.(2185-2187)CTC>CTG	p.L729L		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	729	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		CGCCGGAGTTGAGGTCGTGCT	0.592													23	68					0	0	0	0	C	73616247	C	C	73616247	2	2	297	1	0	0	0	0	0	0	0	1	7038	1277	45	2		2	HCN4	15	73616247	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	9412101	73616247	28915145	136	55051											
NEIL1	79661	broad.mit.edu	37	chr15	75641450	75641450	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cctctgcctggggcccagccCcaacaggagccactggccct	6	5	11	19	0	1	0	0	0	1	0	1	1	1	1	7	4	4	0	7	4	1	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr15:75641450C>G	uc002bad.2	+	2	710	c.204C>G	c.(202-204)CCC>CCG	p.P68P	NEIL1_uc002bae.2_Silent_p.P154P	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1	68					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			ovary(1)	1						GGGCCCAGCCCCAACAGGAGC	0.657								BER_DNA_glycosylases					13	44					0	0	0	0	G	75641450	G	G	75641450	2	3	297	1	0	0	0	0	0	0	0	1	10372	610	22	4		4	NEIL1	15	75641450	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	2025203	75641450	26889942	137	55052											
PKD1	5310	broad.mit.edu	37	chr16	2159316	2159316	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctcacgtggtttttgcccCgcacgctcaccacgtggtct	5	11	10	15	4	3	0	2	0	1	0	3	0	3	0	3	2	2	4	3	2	0	2	rs137905643	byFrequency	TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:2159316C>T	uc002cos.1	-	15	6061	c.5852G>A	c.(5851-5853)CGG>CAG	p.R1951Q	PKD1_uc002cot.1_Missense_Mutation_p.R1951Q	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1951	Extracellular (Potential).|PKD 15.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GTTTTTGCCCCGCACGCTCAC	0.706													5	28					0	0	0	0	T	2159316	T	T	2159316	3	4	297	1	0	0	0	0	1	0	0	0	12018	652	23	1	7187	1	PKD1	16	2159316	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		2159316	88195437	138	55053											
MGRN1	23295	broad.mit.edu	37	chr16	4714767	4714767	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcatccaggctgtggtggacGaaggagatggtgagtgcgtc	8	9	17	7	2	1	2	1	1	0	1	3	5	2	3	1	5	1	1	1	5	1	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:4714767G>T	uc002cwz.2	+	6	755	c.619G>T	c.(619-621)GAA>TAA	p.E207*	MGRN1_uc002cxa.2_Nonsense_Mutation_p.E207*|MGRN1_uc010btx.2_Nonsense_Mutation_p.E207*|MGRN1_uc010btw.2_Nonsense_Mutation_p.E207*|MGRN1_uc002cxb.2_Nonsense_Mutation_p.E207*|MGRN1_uc010uxo.1_Nonsense_Mutation_p.E207*|MGRN1_uc010uxp.1_Nonsense_Mutation_p.E207*|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	207					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						TGTGGTGGACGAAGGAGATGG	0.592													18	61					1.67942e-08	3.04658e-08	1	0	T	4714767	T	T	4714767	4	4	297	1	0	0	0	0	0	1	0	0	9612	1059	37	3	641	3	MGRN1	16	4714767	Nonsense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	2555451	4714767	85639986	139	55054											
NUDT16L1	84309	broad.mit.edu	37	chr16	4745024	4745024	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtcggaggcttccccaacttCctgagcaacgccttcgtgag	7	9	11	14	3	0	2	0	2	0	0	4	3	2	3	4	2	3	2	4	2	2	3	rs143151090		TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:4745024C>G	uc002cxe.2	+	3	492	c.480C>G	c.(478-480)TTC>TTG	p.F160L	NUDT16L1_uc002cxf.1_3'UTR	NM_032349	NP_115725	Q9BRJ7	SDOS_HUMAN	syndesmos	160	Interaction with PXN (By similarity).					cytoplasm	hydrolase activity				0						TCCCCAACTTCCTGAGCAACG	0.642													8	46					0	0	0	0	G	4745024	G	G	4745024	3	3	297	1	0	0	0	0	1	0	0	0	10787	854	30	2	490	2	NUDT16L1	16	4745024	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	30257	4745024	85609729	140	55055											
GGA2	23062	broad.mit.edu	37	chr16	23498078	23498078	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtttgcagcctgaaggtcctCggggtggttgctctttagaa	6	13	14	8	1	1	2	0	1	1	1	3	2	2	2	2	4	3	4	2	4	3	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:23498078C>G	uc002dlq.2	-	7	689	c.613G>C	c.(613-615)GAG>CAG	p.E205Q	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	205	GAT.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		TGAAGGTCCTCGGGGTGGTTG	0.507													64	154					0	0	0	0	G	23498078	G	G	23498078	3	3	297	1	0	0	0	0	1	0	0	0	6390	893	31	3	1272	3	GGA2	16	23498078	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	18753054	23498078	66856675	141	55056											
SEPT1	1731	broad.mit.edu	37	chr16	30393647	30393647	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cttgacagacttgcggtgcaGctggttggggagggcagcaa	8	8	17	8	1	0	2	0	1	0	1	0	3	0	3	0	5	4	5	0	5	1	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:30393647G>C	uc002dxy.2	-	3	230	c.43C>G	c.(43-45)CTG>GTG	p.L15V	SEPT1_uc002dxx.2_5'UTR|SEPT1_uc010veq.1_Missense_Mutation_p.L62V	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	15					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			TTGCGGTGCAGCTGGTTGGGG	0.582													11	39					0	0	0	0	C	30393647	C	C	30393647	3	2	297	1	0	0	0	0	1	0	0	0	14124	962	34	4	1100	4	SEPT1	16	30393647	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	6895569	30393647	59961106	142	55057											
ZNF768	79724	broad.mit.edu	37	chr16	30536711	30536711	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccctgcccacccctggcccgGccaccccgccgacctggacc	4	3	9	25	3	0	0	0	0	0	0	0	2	0	1	11	3	1	0	11	3	0	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:30536711G>A	uc002dyk.3	-	2	926	c.750C>T	c.(748-750)GGC>GGT	p.G250G	ZNF768_uc010vex.1_Silent_p.G219G|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Silent_p.G219G	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	250					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						CCCTGGCCCGGCCACCCCGCC	0.662													4	83					0	0	0	0	A	30536711	A	A	30536711	2	1	297	1	0	0	0	0	0	0	0	1	18208	1190	42	4		4	ZNF768	16	30536711	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	143064	30536711	59818042	143	55058											
OGFOD1	55239	broad.mit.edu	37	chr16	56503929	56503929	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctagcctgagaaattcacGaaagtctgtgaggccttgga	11	11	11	8	1	3	2	1	2	2	1	3	5	3	3	2	2	1	0	2	2	3	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:56503929G>A	uc002ejb.2	+	9	1016	c.915G>A	c.(913-915)ACG>ACA	p.T305T	OGFOD1_uc002ejc.2_Silent_p.T165T	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	305							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	AGAAATTCACGAAAGTCTGTG	0.478													9	36					0	0	0	0	A	56503929	A	A	56503929	2	1	297	1	0	0	0	0	0	0	0	1	10895	1045	37	1		1	OGFOD1	16	56503929	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	25967218	56503929	33850824	144	55059											
ATP6V0D1	9114	broad.mit.edu	37	chr16	67487539	67487539	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctccttgagccggtcatcGatgactgacaccgtcagagg	8	10	11	12	3	3	4	2	3	1	1	5	5	3	4	3	2	1	0	3	2	0	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:67487539G>A	uc002ete.1	-	2	310	c.210C>T	c.(208-210)ATC>ATT	p.I70I	ATP6V0D1_uc010vjo.1_Silent_p.I70I|ATP6V0D1_uc010vjn.1_5'UTR	NM_004691	NP_004682	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	70					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		GCCGGTCATCGATGACTGACA	0.532													23	52					0	0	0	0	A	67487539	A	A	67487539	2	1	297	1	0	0	0	0	0	0	0	1	1175	1048	37	1		1	ATP6V0D1	16	67487539	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	10983610	67487539	22867214	145	55060											
FAM65A	79567	broad.mit.edu	37	chr16	67578271	67578271	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgcccgccccctcagcacGgggtgtccagctctggatgc	5	7	13	16	2	2	0	1	0	1	0	3	1	3	1	4	3	4	2	4	3	0	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:67578271G>A	uc010vjp.1	+	15	2826	c.2730G>A	c.(2728-2730)ACG>ACA	p.T910T	FAM65A_uc002eth.2_Silent_p.T890T|FAM65A_uc010cej.2_Silent_p.T893T|FAM65A_uc010vjq.1_Silent_p.T904T|FAM65A_uc002etk.2_Silent_p.T888T	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	894						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CCCTCAGCACGGGGTGTCCAG	0.637													6	115					0	0	0	0	A	67578271	A	A	67578271	2	1	297	1	0	0	0	0	0	0	0	1	5631	1103	39	1		1	FAM65A	16	67578271	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	90732	67578271	22776482	146	55061											
WWP2	11060	broad.mit.edu	37	chr16	69965757	69965757	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggctctacatcatcatgcGtggcgaggagggcctggact	7	8	14	12	3	3	0	2	0	1	0	3	3	3	2	2	5	2	1	2	5	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:69965757G>A	uc002exu.1	+	17	1735	c.1646G>A	c.(1645-1647)CGT>CAT	p.R549H	WWP2_uc002exv.1_Missense_Mutation_p.R549H|WWP2_uc010vlm.1_Missense_Mutation_p.R433H|WWP2_uc010vln.1_Missense_Mutation_p.R167H|WWP2_uc002exw.1_Missense_Mutation_p.R110H|uc002exx.1_5'Flank|MIR140_hsa-mir-140|MI0000456_5'Flank	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	549	HECT.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						ATCATCATGCGTGGCGAGGAG	0.622													37	117					0	0	0	0	A	69965757	A	A	69965757	3	1	297	1	0	0	0	0	1	0	0	0	17484	1145	40	1	1708	1	WWP2	16	69965757	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	2387486	69965757	20388996	147	55062											
CDYL2	124359	broad.mit.edu	37	chr16	80638305	80638305	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tcagacttcataaattttgtCctgcaggtagctgaaaaggg	12	12	10	7	0	2	2	2	1	0	1	3	2	3	2	1	2	2	3	1	2	5	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:80638305C>T	uc002ffs.2	-	7	1606	c.1501G>A	c.(1501-1503)GAC>AAC	p.D501N		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	501						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						TAAATTTTGTCCTGCAGGTAG	0.557													23	66					0	0	0	0	T	80638305	T	T	80638305	3	4	297	1	0	0	0	0	1	0	0	0	3201	855	30	2	23	2	CDYL2	16	80638305	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	10672548	80638305	9716448	148	55063											
PKD1L2	114780	broad.mit.edu	37	chr16	81193337	81193337	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ctgccgggggctggctccagGtcagactcagggaccacagt	7	6	15	13	1	2	1	2	0	0	1	3	2	3	2	3	5	1	2	3	5	0	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:81193337G>A	uc002fgh.1	-	23	3786	c.3786C>T	c.(3784-3786)GAC>GAT	p.D1262D	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1262	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTGGCTCCAGGTCAGACTCAG	0.592													5	17					0	0	0	0	A	81193337	A	A	81193337	2	1	297	1	0	0	0	0	0	0	0	1	12020	1252	44	4		4	PKD1L2	16	81193337	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	555032	81193337	9161416	149	55064											
MBTPS1	8720	broad.mit.edu	37	chr16	84132678	84132678	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	attcagcatacttgagggaaCgaaagacttttcgttggggc	11	11	12	7	2	1	2	1	1	0	1	2	4	1	3	0	3	3	2	0	3	3	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr16:84132678C>G	uc002fhi.2	-	3	903	c.401G>C	c.(400-402)CGT>CCT	p.R134P		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	134					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						CTTGAGGGAACGAAAGACTTT	0.328													18	71					0	0	0	0	G	84132678	G	G	84132678	3	3	297	1	0	0	0	0	1	0	0	0	9414	536	19	3	2841	3	MBTPS1	16	84132678	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	2939341	84132678	6222075	150	55065											
TIMM22	29928	broad.mit.edu	37	chr17	902756	902756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acttccctgcccacagtaccGgggaacatcagactggaaga	12	6	10	13	1	1	2	1	0	0	2	2	4	2	4	3	3	3	1	3	3	3	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:902756G>A	uc002fsc.2	+	3	466	c.440G>A	c.(439-441)CGG>CAG	p.R147Q		NM_013337	NP_037469	Q9Y584	TIM22_HUMAN	translocase of inner mitochondrial membrane 22	147					transmembrane transport	integral to membrane|mitochondrial inner membrane	protein transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CCACAGTACCGGGGAACATCA	0.488													39	101					0	0	0	0	A	902756	A	A	902756	3	1	297	1	0	0	0	0	1	0	0	0	15976	1116	39	1	450	1	TIMM22	17	902756	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08		902756	80292454	151	55066											
DPH1	1801	broad.mit.edu	37	chr17	1936810	1936810	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccattctaggtcgggcccctCggggccgcgtggccaatcag	5	7	14	15	4	2	0	1	0	1	0	4	0	2	0	5	5	0	0	5	5	2	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:1936810C>T	uc002fts.2	+	2	106	c.88C>T	c.(88-90)CGG>TGG	p.R30W	DPH1_uc002ftr.1_RNA|DPH1_uc002ftt.2_Missense_Mutation_p.R25W|DPH1_uc010cjx.2_5'UTR|DPH1_uc010vqs.1_Missense_Mutation_p.R40W	NM_001383	NP_001374	Q9BZG8	DPH1_HUMAN	diptheria toxin resistance protein required for	30					peptidyl-diphthamide biosynthetic process from peptidyl-histidine|translation	cytoplasm|nucleus				pancreas(1)	1						TCGGGCCCCTCGGGGCCGCGT	0.468													27	75					0	0	0	0	T	1936810	T	T	1936810	3	4	297	1	0	0	0	0	1	0	0	0	4741	875	31	1	94	1	DPH1	17	1936810	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	1034054	1936810	79258400	152	55067											
KIAA0664	23277	broad.mit.edu	37	chr17	2597272	2597272	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gtctccacgtgcatggctccGtagacgttgttaaacaggtt	8	12	11	10	3	1	1	0	0	1	1	3	1	2	1	2	2	2	6	2	2	3	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:2597272G>C	uc002fuy.1	-	19	3122	c.3036C>G	c.(3034-3036)TAC>TAG	p.Y1012*	KIAA0664_uc002fux.1_Nonsense_Mutation_p.Y945*|KIAA0664_uc010ckc.1_5'UTR	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	1012							binding			breast(2)	2						GCATGGCTCCGTAGACGTTGT	0.642													9	29					0	0	0	0	C	2597272	C	C	2597272	4	2	297	1	0	0	0	0	0	1	0	0	8228	1140	40	3	925	3	KIAA0664	17	2597272	Nonsense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	660462	2597272	78597938	153	55068											
TMEM95	339168	broad.mit.edu	37	chr17	7259577	7259578	+	Frame_Shift_Del	DEL	CG	-	-																															cggaggtgtcctgctggcccCgaaagcgctgcttcccaggt																								rs142054857		TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:7259577_7259578delCG	uc002ggh.1	+	5	418_419	c.391_392delCG	c.(391-393)CGAfs	p.R131fs	TMEM95_uc002ggf.1_Frame_Shift_Del_p.R139fs|TMEM95_uc002ggg.1_Frame_Shift_Del_p.R131fs	NM_198154	NP_937797	Q3KNT9	TMM95_HUMAN	transmembrane protein 95	131	Extracellular (Potential).					integral to membrane					0		Prostate(122;0.173)				CTGCTGGCCCCGAAAGCGCTGC	0.678											OREG0024137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								-	7259578	-	-	7259577	7	5	297	1	0	1	0	1	0	0	0	0	16289	644	23	0	433	0	TMEM95	17	7259577	Frame_Shift_Del	DEL	CG	TCGA-HD-7229-01A-11D-2012-08	4662305	7259577	73935633	154	55069											
TP53	7157	broad.mit.edu	37	chr17	7578395	7578395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gctatctgagcagcgctcatGgtgggggcagcgcctcacaa	8	7	14	12	2	3	1	2	1	1	0	3	1	3	1	1	3	3	4	1	3	2	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:7578395G>A	uc002gim.2	-	5	729	c.535C>T	c.(535-537)CAT>TAT	p.H179Y	TP53_uc002gig.1_Missense_Mutation_p.H179Y|TP53_uc002gih.2_Missense_Mutation_p.H179Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47Y|TP53_uc010cng.1_Missense_Mutation_p.H47Y|TP53_uc002gii.1_Missense_Mutation_p.H47Y|TP53_uc010cnh.1_Missense_Mutation_p.H179Y|TP53_uc010cni.1_Missense_Mutation_p.H179Y|TP53_uc002gij.2_Missense_Mutation_p.H179Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86Y|TP53_uc002gio.2_Missense_Mutation_p.H47Y|TP53_uc010vug.1_Missense_Mutation_p.H140Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCTCATGGTGGGGGCAG	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	29					0	0	0	0	A	7578395	A	A	7578395	3	1	297	1	0	0	0	0	1	0	0	0	16448	1348	47	4	763	4	TP53	17	7578395	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	318818	7578395	73616815	155	55070											
CCDC144A	9720	broad.mit.edu	37	chr17	16638738	16638738	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctacaaagtgaaaatatgttGcttcgacagcaactggatga	15	10	9	7	1	0	2	0	2	0	0	1	4	0	3	0	1	4	3	0	1	6	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:16638738G>A	uc002gqk.1	+	12	3229	c.3153G>A	c.(3151-3153)TTG>TTA	p.L1051L	CCDC144A_uc002gql.1_Silent_p.L521L|LOC162632_uc010cpj.1_RNA	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	1051	Potential.										0						AAAATATGTTGCTTCGACAGC	0.378													10	26					0	0	0	0	A	16638738	A	A	16638738	2	1	297	1	0	0	0	0	0	0	0	1	2789	1310	46	4		4	CCDC144A	17	16638738	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	9060343	16638738	64556472	156	55071											
MPP3	4356	broad.mit.edu	37	chr17	41898342	41898343	+	Frame_Shift_Ins	INS	-	GC	GC																															accacctccaggacctgcctINSgcgctggaagggcaggcccg																										TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:41898342_41898343insGC	uc002iei.3	-	11	934_935	c.768_769insGC	c.(766-771)CGCAGGfs	p.R256fs	MPP3_uc002ieh.2_Frame_Shift_Ins_p.R281fs|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Frame_Shift_Ins_p.R256fs|MPP3_uc010wik.1_Frame_Shift_Ins_p.R281fs	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	256_257	SH3.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		AGGACCTGCCTGCGCTGGAAGG	0.683													---	---	---								GC	41898343	GC	GC	41898342	7	5	297	1	0	1	1	0	0	0	0	0	9788	1579	55	0	1028	0	MPP3	17	41898342	Frame_Shift_Ins	INS	-	TCGA-HD-7229-01A-11D-2012-08	25259604	41898342	39296868	157	55072											
NMT1	4836	broad.mit.edu	37	chr17	43180413	43180413	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cttgaagcaatttcaccttaCgcccgtcatgagccaggagg	10	9	10	12	2	2	2	2	2	0	0	2	3	2	3	3	2	3	1	3	2	3	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:43180413C>T	uc002ihz.2	+	9	1106	c.1088C>T	c.(1087-1089)ACG>ATG	p.T363M	NMT1_uc002iia.2_RNA|NMT1_uc010dad.1_Missense_Mutation_p.T23M	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	363					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				TTTCACCTTACGCCCGTCATG	0.547													23	70					0	0	0	0	T	43180413	T	T	43180413	3	4	297	1	0	0	0	0	1	0	0	0	10557	536	19	1	1122	1	NMT1	17	43180413	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	1282071	43180413	38014797	158	55073											
IMP5	162540	broad.mit.edu	37	chr17	43923892	43923892	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	atgtgtgggctcggctgtgcCccttcagctggctctaggca	4	11	14	12	1	2	0	1	0	1	0	3	0	2	0	2	4	2	5	2	4	1	2	rs140347532	byFrequency	TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:43923892C>T	uc010wka.1	+	1	1620	c.1620C>T	c.(1618-1620)GCC>GCT	p.A540A	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	540	Extracellular (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		TCGGCTGTGCCCCTTCAGCTG	0.642													27	49					0	0	0	0	T	43923892	T	T	43923892	2	4	297	1	0	0	0	0	0	0	0	1	7760	610	22	4		4	IMP5	17	43923892	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	743479	43923892	37271318	159	55074											
MAPT	4137	broad.mit.edu	37	chr17	44060865	44060865	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tgagtcctccccccaagactCccctccctccaaggcctccc	6	7	5	23	0	0	2	0	1	0	1	6	2	6	2	10	1	0	0	10	1	2	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:44060865C>A	uc002ijr.3	+	6	1015	c.695C>A	c.(694-696)TCC>TAC	p.S232Y	MAPT_uc010dau.2_Missense_Mutation_p.S232Y|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	232					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CCCCAAGACTCCCCTCCCTCC	0.692													23	19					1.22574e-08	2.2348e-08	1	0	A	44060865	A	A	44060865	3	1	297	1	0	0	0	0	1	0	0	0	9350	855	30	2	713	2	MAPT	17	44060865	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	136973	44060865	37134345	160	55075											
PCTP	58488	broad.mit.edu	37	chr17	53848541	53848541	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acccttttcccatgtccaacAgagacgtatcctttccacaa	11	11	4	15	1	0	1	0	0	0	1	4	2	4	1	5	0	1	1	5	0	3	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:53848541A>G	uc002iul.3	+	3	443	c.334A>G	c.(334-336)AGA>GGA	p.R112G	PCTP_uc002ium.3_Missense_Mutation_p.R40G|PCTP_uc010dcg.2_Intron|PCTP_uc010dch.2_RNA	NM_021213	NP_067036	Q9UKL6	PPCT_HUMAN	phosphatidylcholine transfer protein isoform 1	112	START.					cytosol	phosphatidylcholine binding|phosphatidylcholine transmembrane transporter activity			lung(1)	1			BRCA - Breast invasive adenocarcinoma(1;0.00207)			CATGTCCAACAGAGACGTATC	0.453													25	61					0	0	0	0	G	53848541	G	G	53848541	3	3	297	1	0	0	0	0	1	0	0	0	11661	180	7	5	344	5	PCTP	17	53848541	Missense_Mutation	SNP	A	TCGA-HD-7229-01A-11D-2012-08	9787676	53848541	27346669	161	55076											
ACTG1	71	broad.mit.edu	37	chr17	79478626	79478626	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggatggccacgtacatggcCggggtgttgaaggtctcaaa	9	9	15	8	2	1	1	1	1	1	0	2	2	1	2	2	6	1	2	2	6	3	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr17:79478626C>A	uc002kaj.1	-	3	415	c.390G>T	c.(388-390)CCG>CCT	p.P130P	ACTG1_uc002kah.1_Silent_p.P8P|ACTG1_uc002kai.1_Silent_p.P87P|ACTG1_uc002kak.1_Silent_p.P130P|ACTG1_uc010wun.1_Silent_p.P130P|ACTG1_uc002kal.1_Silent_p.P130P|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	130					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			CGTACATGGCCGGGGTGTTGA	0.612													43	79					1.03325e-14	1.92269e-14	1	0	A	79478626	A	A	79478626	2	1	297	1	0	0	0	0	0	0	0	1	196	639	23	3		3	ACTG1	17	79478626	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	25630085	79478626	1716584	162	55077											
CHMP1B	57132	broad.mit.edu	37	chr18	11851736	11851736	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtgcgcgagtcgatgcagtgGctgccagggtccagacggcg	6	6	18	11	5	0	1	0	0	0	1	2	3	1	1	2	3	3	2	2	3	0	0			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr18:11851736G>T	uc002kqe.2	+	1	348	c.226G>T	c.(226-228)GCT>TCT	p.A76S	GNAL_uc002kqc.2_Intron|GNAL_uc010dkz.2_Intron|GNAL_uc002kqd.2_Intron	NM_020412	NP_065145	Q7LBR1	CHM1B_HUMAN	chromatin modifying protein 1B	76					cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding				0						CGATGCAGTGGCTGCCAGGGT	0.552													42	100					3.76604e-16	7.15547e-16	1	0	T	11851736	T	T	11851736	3	4	297	1	0	0	0	0	1	0	0	0	3368	1203	42	4	228	4	CHMP1B	18	11851736	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08		11851736	66225512	163	55078											
PMAIP1	5366	broad.mit.edu	37	chr18	57569886	57569889	+	Frame_Shift_Del	DEL	AGTC	-	-																															ctttccttctcagagctggaAgtcgagtgtgctactcaact																										TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr18:57569886_57569889delAGTC	uc002lic.2	+	2	284_287	c.66_69delAGTC	c.(64-69)GAAGTCfs	p.E22fs	PMAIP1_uc002lid.2_Frame_Shift_Del_p.S73fs	NM_021127	NP_066950	Q13794	APR_HUMAN	phorbol-12-myristate-13-acetate-induced protein	22_23					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to glucose starvation|cellular response to hypoxia|negative regulation of mitochondrial membrane potential|positive regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of glucose metabolic process|positive regulation of protein oligomerization|positive regulation of release of cytochrome c from mitochondria|proteasomal protein catabolic process|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability|response to dsRNA|signal transduction by p53 class mediator resulting in induction of apoptosis|T cell homeostasis|virus-infected cell apoptosis	cytosol|mitochondrial outer membrane|nucleus	protein binding				0		Colorectal(73;0.0946)				CAGAGCTGGAAGTCGAGTGTGCTA	0.431													---	---	---								-	57569889	-	-	57569886	7	5	297	1	0	1	0	1	0	0	0	0	12185	69	3	0	72	0	PMAIP1	18	57569886	Frame_Shift_Del	DEL	AGTC	TCGA-HD-7229-01A-11D-2012-08	45718150	57569886	20507362	164	55079											
HMHA1	23526	broad.mit.edu	37	chr19	1084297	1084297	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgccgtacctggaggcgggcGaggcggtggtctacccgctg	4	7	18	12	5	1	0	0	0	1	0	1	2	1	1	3	6	3	2	3	6	2	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:1084297G>A	uc002lqz.1	+	22	3247	c.3016G>A	c.(3016-3018)GAG>AAG	p.E1006K	HMHA1_uc010xgd.1_Missense_Mutation_p.E1022K|HMHA1_uc010xge.1_Missense_Mutation_p.E874K|HMHA1_uc002lra.1_Missense_Mutation_p.E846K|HMHA1_uc002lrb.1_Missense_Mutation_p.E889K|HMHA1_uc002lrc.1_Missense_Mutation_p.E641K|HMHA1_uc002lrd.1_Missense_Mutation_p.E82K|HMHA1_uc010dsd.1_Missense_Mutation_p.E112K	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	1006					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGGCGGGCGAGGCGGTGGT	0.687													39	65					0	0	0	0	A	1084297	A	A	1084297	3	1	297	1	0	0	0	0	1	0	0	0	7279	1059	37	1	3102	1	HMHA1	19	1084297	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08		1084297	58044686	165	55080											
GPX4	2879	broad.mit.edu	37	chr19	1105487	1105487	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tttgcggatcctggccttccCgtgtaaccagttcgggaagc	6	11	12	12	3	0	0	0	0	0	0	3	2	2	2	4	3	3	2	4	3	2	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:1105487C>T	uc010xgg.1	+	4	409	c.302C>T	c.(301-303)CCG>CTG	p.P101L	GPX4_uc010xgh.1_Missense_Mutation_p.P101L|GPX4_uc010xgi.1_Missense_Mutation_p.P138L	NM_002085	NP_002076	P36969	GPX4_HUMAN	glutathione peroxidase 4 isoform A precursor	101					multicellular organismal development|phospholipid metabolic process		glutathione peroxidase activity|phospholipid-hydroperoxide glutathione peroxidase activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glutathione(DB00143)	CTGGCCTTCCCGTGTAACCAG	0.667													15	42					0	0	0	0	T	1105487	T	T	1105487	3	4	297	1	0	0	0	0	1	0	0	0	6781	652	23	1	511	1	GPX4	19	1105487	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	21190	1105487	58023496	166	55081											
CLEC4M	10332	broad.mit.edu	37	chr19	7831597	7831597	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttcttccaaggaaactgttaCttcatgtctaactcccagcg	10	13	6	12	1	3	0	1	0	2	0	5	1	5	1	2	1	4	1	2	1	4	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:7831597C>G	uc002mih.2	+	6	889	c.771C>G	c.(769-771)TAC>TAG	p.Y257*	CLEC4M_uc010xjv.1_3'UTR|CLEC4M_uc002mhy.2_3'UTR|CLEC4M_uc010xjw.1_Nonsense_Mutation_p.Y213*|CLEC4M_uc010dvt.2_Nonsense_Mutation_p.Y234*|CLEC4M_uc010dvs.2_Nonsense_Mutation_p.Y256*|CLEC4M_uc010xjx.1_Nonsense_Mutation_p.Y229*|CLEC4M_uc002mhz.2_Nonsense_Mutation_p.Y188*|CLEC4M_uc002mic.2_Nonsense_Mutation_p.Y252*|CLEC4M_uc002mia.2_Nonsense_Mutation_p.Y144*	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	280	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						GAAACTGTTACTTCATGTCTA	0.577													17	75					0	0	0	0	G	7831597	G	G	7831597	4	3	297	1	0	0	0	0	0	1	0	0	3533	576	20	4	879	4	CLEC4M	19	7831597	Nonsense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	6726110	7831597	51297386	167	55082											
COL5A3	50509	broad.mit.edu	37	chr19	10090691	10090691	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggggggccctttggcccaggGaatcctggagggccttgcag	5	7	18	11	0	0	0	0	0	0	0	1	2	1	2	4	7	1	1	4	7	1	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:10090691G>A	uc002mmq.1	-	36	2723	c.2637C>T	c.(2635-2637)TTC>TTT	p.F879F		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	879	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TTGGCCCAGGGAATCCTGGAG	0.612													9	26					0	0	0	0	A	10090691	A	A	10090691	2	1	297	1	0	0	0	0	0	0	0	1	3713	1165	41	2		2	COL5A3	19	10090691	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	2259094	10090691	49038292	168	55083											
DNM2	1785	broad.mit.edu	37	chr19	10923011	10923011	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctccaaggagtactggttTgtgctgactgccgagtcact	7	11	13	10	1	1	1	1	1	0	0	2	3	2	2	2	3	3	4	2	3	2	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:10923011T>C	uc002mps.1	+	15	1793	c.1629T>C	c.(1627-1629)TTT>TTC	p.F543F	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Silent_p.F543F|DNM2_uc002mpv.1_Silent_p.F539F|DNM2_uc002mpu.1_Silent_p.F539F|DNM2_uc010dxl.1_Silent_p.F543F|DNM2_uc002mpw.2_Silent_p.F272F	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	543	PH.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			AGTACTGGTTTGTGCTGACTG	0.622													3	14					0	0	0	0	C	10923011	C	C	10923011	2	2	297	1	0	0	0	0	0	0	0	1	4694	1809	63	5		5	DNM2	19	10923011	Silent	SNP	T	TCGA-HD-7229-01A-11D-2012-08	832320	10923011	48205972	169	55084											
NOTCH3	4854	broad.mit.edu	37	chr19	15299887	15299887	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgacagacactcgttgacatCggtctcacagcgaggtccag	10	7	11	13	4	1	2	1	1	1	1	5	4	2	2	1	2	1	1	1	2	0	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:15299887C>T	uc002nan.2	-	8	1367	c.1291G>A	c.(1291-1293)GAT>AAT	p.D431N	NOTCH3_uc002nao.1_Missense_Mutation_p.D431N	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	431	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TCGTTGACATCGGTCTCACAG	0.642													24	39					0	0	0	0	T	15299887	T	T	15299887	3	4	297	1	0	0	0	0	1	0	0	0	10604	884	31	1	5778	1	NOTCH3	19	15299887	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	4376876	15299887	43829096	170	55085											
C19orf44	84167	broad.mit.edu	37	chr19	16613911	16613911	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agagcatttactgtacccagCgtggaactctccagcgcaaa	12	8	9	12	2	1	1	0	0	1	1	2	2	1	2	2	1	6	3	2	1	4	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:16613911C>T	uc002neh.1	+	3	868	c.795C>T	c.(793-795)AGC>AGT	p.S265S	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Silent_p.S265S|C19orf44_uc002neg.2_Silent_p.S265S|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	265											0						CTGTACCCAGCGTGGAACTCT	0.428													34	60					0	0	0	0	T	16613911	T	T	16613911	2	4	297	1	0	0	0	0	0	0	0	1	1936	767	27	1		1	C19orf44	19	16613911	Silent	SNP	C	TCGA-HD-7229-01A-11D-2012-08	1314024	16613911	42515072	171	55086											
ZNF90	7643	broad.mit.edu	37	chr19	20229606	20229606	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctcctcaacacttactataCataagataagtcatactgaa	16	11	4	10	0	2	2	2	1	0	1	3	2	3	2	1	0	4	1	1	0	8	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:20229606C>G	uc002nor.2	+	4	1382	c.1243C>G	c.(1243-1245)CAT>GAT	p.H415D	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	415	C2H2-type 9.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						ACTTACTATACATAAGATAAG	0.373													7	10					0	0	0	0	G	20229606	G	G	20229606	3	3	297	1	0	0	0	0	1	0	0	0	18266	478	17	4	1257	4	ZNF90	19	20229606	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	3615695	20229606	38899377	172	55087											
RBM42	79171	broad.mit.edu	37	chr19	36120554	36120554	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cctgtgatccgcccaattatCgcgaccaacacataccagca	12	7	6	16	3	0	1	0	1	0	0	2	2	1	1	5	0	3	1	5	0	4	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:36120554C>G	uc002oan.2	+	2	337	c.261C>G	c.(259-261)ATC>ATG	p.I87M	RBM42_uc010xsx.1_Missense_Mutation_p.I87M|RBM42_uc010eef.2_Missense_Mutation_p.I87M|RBM42_uc002oao.2_Missense_Mutation_p.I87M|RBM42_uc002oap.2_Missense_Mutation_p.I87M|RBM42_uc002oaq.2_Missense_Mutation_p.I87M|RBM42_uc010eeg.2_Missense_Mutation_p.I87M	NM_024321	NP_077297	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	87						cytoplasm|nucleus	nucleotide binding|RNA binding				0	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCCCAATTATCGCGACCAACA	0.567													14	63					0	0	0	0	G	36120554	G	G	36120554	3	3	297	1	0	0	0	0	1	0	0	0	13201	874	31	3	267	3	RBM42	19	36120554	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	15890948	36120554	23008429	173	55088											
RINL	126432	broad.mit.edu	37	chr19	39361379	39361379	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggacccccagaatctgaggcGatgcgcacccgaaggcttcg	9	5	13	14	4	1	2	0	1	1	1	2	5	1	3	3	3	1	2	3	3	2	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:39361379G>A	uc002ojq.2	-	8	901	c.513C>T	c.(511-513)ATC>ATT	p.I171I	RINL_uc002ojr.1_5'Flank|RINL_uc010xuo.1_Silent_p.I285I	NM_198445	NP_940847	Q6ZS11	RINL_HUMAN	Ras and Rab interactor-like	171							GTPase activator activity			pancreas(1)	1						AATCTGAGGCGATGCGCACCC	0.647													14	31					0	0	0	0	A	39361379	A	A	39361379	2	1	297	1	0	0	0	0	0	0	0	1	13440	1048	37	1		1	RINL	19	39361379	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	3240825	39361379	19767604	174	55089											
SARS2	54938	broad.mit.edu	37	chr19	39439299	39439299	+	Translation_Start_Site	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgttcccgccatgctccacCtcccagcctctgaagccctc	5	8	6	22	2	1	1	0	1	1	0	5	1	4	1	8	0	3	2	8	0	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:39439299C>A	uc010xuq.1	-	2	82	c.-126G>T	c.(-128--124)GAGGT>GATGT		FBXO17_uc002okg.1_Missense_Mutation_p.E123D|FBXO17_uc002okf.1_Missense_Mutation_p.E132D	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor						seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CATGCTCCACCTCCCAGCCTC	0.587													17	31					6.44725e-10	1.18748e-09	1	0	A	39439299	A	A	39439299	1	1	297	1	0	0	0	0	0	0	0	0	13910	680	24	4		4	SARS2	19	39439299	Translation_Start_Site	SNP	C	TCGA-HD-7229-01A-11D-2012-08	77920	39439299	19689684	175	55090											
GALP	85569	broad.mit.edu	37	chr19	56688559	56688559	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccagcatccgcacctgccCaccgggtaacgcctccctaa	8	6	7	20	3	0	0	0	0	0	0	3	0	3	0	7	1	3	3	7	1	2	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr19:56688559C>T	uc002qmo.1	+	2	164	c.82C>T	c.(82-84)CAC>TAC	p.H28Y	GALP_uc010eti.2_Missense_Mutation_p.H28Y	NM_033106	NP_149097	Q9UBC7	GALP_HUMAN	galanin-like peptide isoform 1 precursor	28					neuropeptide signaling pathway	extracellular region	hormone activity				0		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		CGCACCTGCCCACCGGGTAAC	0.587													4	19					0	0	0	0	T	56688559	T	T	56688559	3	4	297	1	0	0	0	0	1	0	0	0	6261	594	21	4	84	4	GALP	19	56688559	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	17249260	56688559	2440424	176	55091											
ESF1	51575	broad.mit.edu	37	chr20	13763380	13763380	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggttttcatttttttaattCctatagaattatctaaatca	13	20	3	5	0	3	1	2	0	1	1	4	1	4	1	1	1	0	1	1	1	7	11			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr20:13763380C>T	uc002woj.2	-	2	515	c.407G>A	c.(406-408)GGA>GAA	p.G136E	ESF1_uc002wok.1_Missense_Mutation_p.G136E|C20orf7_uc002wol.1_5'Flank|C20orf7_uc002wom.2_5'Flank|C20orf7_uc002won.2_5'Flank|C20orf7_uc002woo.2_5'Flank	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	136	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						TTTTTTAATTCCTATAGAATT	0.264													5	24					0	0	0	0	T	13763380	T	T	13763380	3	4	297	1	0	0	0	0	1	0	0	0	5275	855	30	2	2200	2	ESF1	20	13763380	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		13763380	49262140	177	55092											
SNX5	27131	broad.mit.edu	37	chr20	17932146	17932146	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cagccaaaggtcacttacctTaactccagtaaaaaggactt	15	9	6	11	0	1	0	1	0	0	0	2	1	2	1	3	2	3	1	3	2	6	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr20:17932146T>G	uc002wqc.2	-	6	693	c.607A>C	c.(607-609)AAG>CAG	p.K203Q	SNX5_uc002wqb.2_RNA|SNX5_uc002wqd.2_Missense_Mutation_p.K203Q|SNX5_uc002wqe.2_Missense_Mutation_p.K98Q|SNX5_uc010zrt.1_Missense_Mutation_p.K203Q	NM_014426	NP_055241	Q9Y5X3	SNX5_HUMAN	sorting nexin 5	203	BAR.				cell communication|pinocytosis|protein transport	cytoplasmic vesicle membrane|early endosome membrane|extrinsic to endosome membrane|extrinsic to internal side of plasma membrane|macropinocytic cup|phagocytic cup|ruffle	phosphatidylinositol binding			large_intestine(1)	1						TCACTTACCTTAACTCCAGTA	0.363													17	24					0	0	0	0	G	17932146	G	G	17932146	3	3	297	1	0	0	0	0	1	0	0	0	14969	1763	61	5	639	5	SNX5	20	17932146	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08	4168766	17932146	45093374	178	55093											
CDK5RAP1	51654	broad.mit.edu	37	chr20	31958354	31958354	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccatgttgtactgaacttccCggagcaaagagactgtctgg	10	10	11	10	1	1	2	0	1	1	1	2	4	2	3	2	2	3	3	2	2	3	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr20:31958354C>G	uc010gek.2	-	12	1509	c.1385G>C	c.(1384-1386)CGG>CCG	p.R462P	CDK5RAP1_uc002wyy.2_Missense_Mutation_p.R358P|CDK5RAP1_uc002wyz.2_Missense_Mutation_p.R448P|CDK5RAP1_uc002wza.2_Missense_Mutation_p.R448P|CDK5RAP1_uc010gel.2_Missense_Mutation_p.R357P|CDK5RAP1_uc010gem.2_Missense_Mutation_p.R371P|CDK5RAP1_uc002wzc.1_Missense_Mutation_p.R448P|CDK5RAP1_uc002wzb.1_Missense_Mutation_p.R83P	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	462					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						CTGAACTTCCCGGAGCAAAGA	0.537													35	122					0	0	0	0	G	31958354	G	G	31958354	3	3	297	1	0	0	0	0	1	0	0	0	3160	652	23	3	436	3	CDK5RAP1	20	31958354	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	14026208	31958354	31067166	179	55094											
SIK1	150094	broad.mit.edu	37	chr21	44839014	44839014	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctcctctaggcccggccccTgcctggcctcctcactgatg	3	9	9	20	1	2	1	1	1	1	0	4	1	4	1	8	3	1	0	8	3	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr21:44839014T>A	uc002zdf.2	-	11	1476	c.1349A>T	c.(1348-1350)CAG>CTG	p.Q450L		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	450					anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						GCCCGGCCCCTGCCTGGCCTC	0.701													5	6					0	0	0	0	A	44839014	A	A	44839014	3	1	297	1	0	0	0	0	1	0	0	0	14382	1580	55	5	1018	5	SIK1	21	44839014	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08		44839014	3290881	180	55095											
HIRA	7290	broad.mit.edu	37	chr22	19398284	19398284	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cccgtcagggtgaatatcaaCtgaaaaaatcggcttgcctg	12	9	10	10	2	2	2	2	2	0	0	3	2	2	2	2	2	2	1	2	2	6	2			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr22:19398284C>T	uc002zpf.1	-	2	275	c.55G>A	c.(55-57)GTT>ATT	p.V19I	HIRA_uc011agx.1_5'UTR|HIRA_uc010grn.1_Missense_Mutation_p.V19I|HIRA_uc010gro.1_5'UTR|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	19	WD 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					TGAATATCAACTGAAAAAATC	0.383													49	157					0	0	0	0	T	19398284	T	T	19398284	3	4	297	1	0	0	0	0	1	0	0	0	7159	565	20	4	3094	4	HIRA	22	19398284	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		19398284	31906282	181	55096											
CSNK1E	1454	broad.mit.edu	37	chr22	38694868	38694868	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gaggttgcggaagagctgacGtaggtaagagtagtcgggct	10	8	18	5	3	0	3	0	1	0	2	1	5	0	4	0	4	2	6	0	4	4	4			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr22:38694868G>A	uc003avj.2	-	7	1069	c.808C>T	c.(808-810)CGT>TGT	p.R270C	CSNK1E_uc003avk.2_Missense_Mutation_p.R270C|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Missense_Mutation_p.R270C|CSNK1E_uc003avo.2_Missense_Mutation_p.R270C|CSNK1E_uc003avp.1_Missense_Mutation_p.R270C|CSNK1E_uc003avq.1_Missense_Mutation_p.R270C	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	270	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)					AAGAGCTGACGTAGGTAAGAG	0.542											OREG0026559	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	98					0	0	0	0	A	38694868	A	A	38694868	3	1	297	1	0	0	0	0	1	0	0	0	3970	1145	40	1	458	1	CSNK1E	22	38694868	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	19296584	38694868	12609698	182	55097											
L3MBTL2	83746	broad.mit.edu	37	chr22	41626178	41626178	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaaggaagagcatctagacGtggcctcgcccgacaaggct	11	6	13	11	3	1	3	0	1	1	2	2	5	1	4	2	3	1	2	2	3	4	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chr22:41626178G>T	uc003azo.2	+	17	2095	c.2041G>T	c.(2041-2043)GTG>TTG	p.V681L	L3MBTL2_uc003azn.2_RNA|CHADL_uc003azq.3_Intron|CHADL_uc010gyj.2_Intron	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	681					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						GCATCTAGACGTGGCCTCGCC	0.607													18	61					6.33239e-15	1.18445e-14	1	0	T	41626178	T	T	41626178	3	4	297	1	0	0	0	0	1	0	0	0	8632	1145	40	3	2107	3	L3MBTL2	22	41626178	Missense_Mutation	SNP	G	TCGA-HD-7229-01A-11D-2012-08	2931310	41626178	9678388	183	55098											
PRKX	5613	broad.mit.edu	37	chrX	3592789	3592789	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctccttcaccaggtgcaccCgcccgaacgtcccagtgcct	6	8	8	19	3	2	0	1	0	1	0	4	1	3	0	6	1	3	1	6	1	1	1			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chrX:3592789C>G	uc010nde.2	-	2	552	c.185G>C	c.(184-186)CGG>CCG	p.R62P		NM_005044	NP_005035	P51817	PRKX_HUMAN	protein kinase, X-linked	62	ATP (By similarity).|Protein kinase.						ATP binding|cAMP-dependent protein kinase activity			skin(2)|lung(1)	3		all_lung(23;0.000396)|Lung NSC(23;0.00123)				CAGGTGCACCCGCCCGAACGT	0.552													25	22					0	0	0	0	G	3592789	G	G	3592789	3	3	297	1	0	0	0	0	1	0	0	0	12589	652	23	3	919	3	PRKX	23	3592789	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08		3592789	151677771	184	55099											
CXorf58	254158	broad.mit.edu	37	chrX	23956699	23956699	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tgtccaacctctatatcggcCctacaaacagcaaaatcaag	15	8	5	13	1	2	0	1	0	1	0	4	0	3	0	3	1	4	1	3	1	8	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chrX:23956699C>A	uc004daz.1	+	8	1165	c.821C>A	c.(820-822)CCC>CAC	p.P274H	CXorf58_uc011mju.1_Missense_Mutation_p.P274H	NM_152761	NP_689974	Q96LI9	CX058_HUMAN	hypothetical protein LOC254158	274											0						CTATATCGGCCCTACAAACAG	0.323													28	25					2.46105e-21	4.72574e-21	1	0	A	23956699	A	A	23956699	3	1	297	1	0	0	0	0	1	0	0	0	4131	623	22	4	847	4	CXorf58	23	23956699	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	20363910	23956699	131313861	185	55100											
KDM6A	7403	broad.mit.edu	37	chrX	44922694	44922694	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caacaggagttgcacaggtaCgatctactggaattcctaat	13	10	9	9	1	1	0	0	0	1	0	2	3	2	2	1	3	4	3	1	3	5	5			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chrX:44922694C>T	uc004dge.3	+	16	1930	c.1555C>T	c.(1555-1557)CGA>TGA	p.R519*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.R485*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.R571*|KDM6A_uc011mla.1_Nonsense_Mutation_p.R474*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.R526*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.R223*|KDM6A_uc011mld.1_Nonsense_Mutation_p.R158*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	519					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TGCACAGGTACGATCTACTGG	0.463			D|N|F|S		renal|oesophageal SCC|MM								19	19					0	0	0	0	T	44922694	T	T	44922694	4	4	297	1	0	0	0	0	0	1	0	0	8176	528	19	1	1617	1	KDM6A	23	44922694	Nonsense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	20965995	44922694	110347866	186	55101											
ACRC	93953	broad.mit.edu	37	chrX	70823685	70823685	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gacgacaatagtgatgattcGgatgttcccgacgacaacag	13	8	11	9	4	0	2	0	2	0	0	2	7	1	3	1	1	1	1	1	1	3	3			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chrX:70823685G>C	uc004eae.2	+	8	1059	c.558G>C	c.(556-558)TCG>TCC	p.S186S	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	186	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					GTGATGATTCGGATGTTCCCG	0.498													95	74					0	0	0	0	C	70823685	C	C	70823685	2	2	297	1	0	0	0	0	0	0	0	1	171	1103	39	3		3	ACRC	23	70823685	Silent	SNP	G	TCGA-HD-7229-01A-11D-2012-08	25900991	70823685	84446875	187	55102											
ENOX2	10495	broad.mit.edu	37	chrX	129771269	129771269	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttgttagggtcatcttcTctgtggactttgccttgttc	3	20	9	9	0	4	0	1	0	3	0	6	1	4	1	1	2	1	2	1	2	1	6			TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chrX:129771269T>G	uc004evw.2	-	12	1750	c.1332A>C	c.(1330-1332)AGA>AGC	p.R444S	ENOX2_uc004evx.2_Missense_Mutation_p.R415S|ENOX2_uc004evy.2_Missense_Mutation_p.R415S|ENOX2_uc004evv.2_Missense_Mutation_p.R269S	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	444	Potential.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						GGTCATCTTCTCTGTGGACTT	0.478													84	54					0	0	0	0	G	129771269	G	G	129771269	3	3	297	1	0	0	0	0	1	0	0	0	5151	1548	54	5	520	5	ENOX2	23	129771269	Missense_Mutation	SNP	T	TCGA-HD-7229-01A-11D-2012-08	58947584	129771269	25499291	188	55103											
IL9R	3581	broad.mit.edu	37	chrX	155235823	155235823	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttctcctgctgactggccCgacctacctcctgttcaagc	5	12	7	17	1	2	1	1	1	1	0	4	2	3	1	5	1	3	2	5	1	2	3	rs145116573	byFrequency	TCGA-HD-7229-01A-11D-2012-08	TCGA-HD-7229-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	26b27991-540f-47f4-95f3-a59a493da593	f1ae29b8-ef4f-4f37-a959-31331e77e66c	g.chrX:155235823C>T	uc004fnv.1	+	7	1036	c.857C>T	c.(856-858)CCG>CTG	p.P286L	IL9R_uc010nvn.2_Missense_Mutation_p.P265L|IL9R_uc004fnu.1_Missense_Mutation_p.P321L	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	286	Helical; (Potential).				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTGACTGGCCCGACCTACCTC	0.448													13	20					0	0	0	0	T	155235823	T	T	155235823	3	4	297	1	0	0	0	0	1	0	0	0	7747	652	23	1	883	1	IL9R	23	155235823	Missense_Mutation	SNP	C	TCGA-HD-7229-01A-11D-2012-08	25464554	155235823	34737	189	55104											
VPS13D	55187	broad.mit.edu	37	chr1	12414089	12414090	+	Frame_Shift_Del	DEL	TC	-	-																															atatgccctcaaacatatttTctgacagtgcaaaacagatt																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:12414089_12414090delTC	uc001atv.2	+	47	9631_9632	c.9490_9491delTC	c.(9490-9492)TCTfs	p.S3164fs	VPS13D_uc001atw.2_Frame_Shift_Del_p.S3139fs|VPS13D_uc001atx.2_Frame_Shift_Del_p.S2351fs	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3163					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AAACATATTTTCTGACAGTGCA	0.356													---	---	---								-	12414090	-	-	12414089	7	5	298	1	0	1	0	1	0	0	0	0	17260	1783	62	0	9672	0	VPS13D	1	12414089	Frame_Shift_Del	DEL	TC	TCGA-HD-7753-01A-11D-2078-08		12414089	236836532	1	55105											
SCMH1	22955	broad.mit.edu	37	chr1	41514424	41514424	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agacggttttctggtgataaGcacagtcgatacaggcctgg	10	10	13	8	2	1	2	0	1	1	1	2	3	1	2	1	4	2	2	1	4	2	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:41514424G>A	uc001cgo.2	-	11	1525	c.1214C>T	c.(1213-1215)GCT>GTT	p.A405V	SCMH1_uc010ojr.1_Missense_Mutation_p.A247V|SCMH1_uc001cgp.2_Missense_Mutation_p.A344V|SCMH1_uc001cgr.2_Missense_Mutation_p.A344V|SCMH1_uc001cgs.2_Missense_Mutation_p.A415V|SCMH1_uc001cgt.2_Missense_Mutation_p.A344V|SCMH1_uc001cgq.2_Missense_Mutation_p.A358V|SCMH1_uc010ojs.1_RNA	NM_001031694	NP_001026864	Q96GD3	SCMH1_HUMAN	sex comb on midleg 1 isoform 1	405					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				CTGGTGATAAGCACAGTCGAT	0.522													29	60					0	0	0	0	A	41514424	A	A	41514424	3	1	298	1	0	0	0	0	1	0	0	0	13973	971	34	4	792	4	SCMH1	1	41514424	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	29100335	41514424	207736197	2	55106											
DOCK7	85440	broad.mit.edu	37	chr1	62921091	62921091	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caagtgcattcagtttagagAtccattttgcgaaggctcat	11	13	9	8	1	2	1	2	0	0	1	3	3	3	1	1	1	2	3	1	1	3	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:62921091A>G	uc001daq.2	-	49	6418	c.6384T>C	c.(6382-6384)GAT>GAC	p.D2128D	DOCK7_uc001dan.2_Silent_p.D1991D|DOCK7_uc001dao.2_Silent_p.D1989D|DOCK7_uc001dap.2_Silent_p.D2108D|DOCK7_uc001dam.2_Silent_p.D1310D	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	2139					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CAGTTTAGAGATCCATTTTGC	0.348													12	28					0	0	0	0	G	62921091	G	G	62921091	2	3	298	1	0	0	0	0	0	0	0	1	4714	330	12	5		5	DOCK7	1	62921091	Silent	SNP	A	TCGA-HD-7753-01A-11D-2078-08	21406667	62921091	186329530	3	55107											
SPAG17	200162	broad.mit.edu	37	chr1	118584559	118584559	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tactatcctctttctctgcgTtatccttgcctttcttttta	4	22	3	12	1	3	0	0	0	3	0	6	0	5	0	3	0	3	1	3	0	4	9			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:118584559T>C	uc001ehk.2	-	21	2989	c.2921A>G	c.(2920-2922)AAC>AGC	p.N974S		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	974						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTTCTCTGCGTTATCCTTGCC	0.393													79	192					0	0	0	0	C	118584559	C	C	118584559	3	2	298	1	0	0	0	0	1	0	0	0	15045	1725	60	5	3862	5	SPAG17	1	118584559	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	55663468	118584559	130666062	4	55108											
TAGLN2	8407	broad.mit.edu	37	chr1	159890213	159890213	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtggtgatccactggatcagGatctgctccagatctgcatc	8	11	11	11	0	3	2	1	1	2	1	6	4	5	4	2	3	2	2	2	3	0	0			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:159890213G>A	uc001fum.1	-	1	137	c.87C>T	c.(85-87)ATC>ATT	p.I29I	CCDC19_uc001ful.2_Intron|TAGLN2_uc001fun.1_Silent_p.I29I|TAGLN2_uc001fuo.1_Silent_p.I29I|TAGLN2_uc010piy.1_Silent_p.I29I	NM_003564	NP_003555	P37802	TAGL2_HUMAN	transgelin 2	29	CH.				muscle organ development	nuclear membrane|plasma membrane	protein binding				0	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACTGGATCAGGATCTGCTCCA	0.582													11	46					0	0	0	0	A	159890213	A	A	159890213	2	1	298	1	0	0	0	0	0	0	0	1	15605	1164	41	2		2	TAGLN2	1	159890213	Silent	SNP	G	TCGA-HD-7753-01A-11D-2078-08	41305654	159890213	89360408	5	55109											
BAT2L2	23215	broad.mit.edu	37	chr1	171509694	171509694	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagagatatgaaagaggaacGggaacagaggaaggagaaag	20	3	16	2	1	0	5	0	1	0	4	0	10	0	8	0	4	2	0	0	4	7	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:171509694G>T	uc010pmg.1	+	16	3349	c.3083G>T	c.(3082-3084)CGG>CTG	p.R1028L	BAT2L2_uc010pmh.1_Missense_Mutation_p.R5L	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1028	Potential.						protein C-terminus binding				0						AAAGAGGAACGGGAACAGAGG	0.433													11	27					4.68919e-08	5.19263e-08	1	0	T	171509694	T	T	171509694	3	4	298	1	0	0	0	0	1	0	0	0	1323	1116	39	3	3141	3	BAT2L2	1	171509694	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	11619481	171509694	77740927	6	55110											
FAM5C	339479	broad.mit.edu	37	chr1	190067946	190067946	+	Silent	SNP	C	T	T																															attcgtctgtccgttttctgCagcagatatttcatctcgag																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:190067946C>T	uc001gse.1	-	8	1735	c.1503G>A	c.(1501-1503)CTG>CTA	p.L501L	FAM5C_uc010pot.1_Silent_p.L399L	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	501						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CCGTTTTCTGCAGCAGATATT	0.502													27	96					0	0	0	0	T	190067946	T	T	190067946	2	4	298	1	0	0	0	0	0	0	0	1	5626	697	25	4		4	FAM5C	1	190067946	Silent	SNP	C	TCGA-HD-7753-01A-11D-2078-08	18558252	190067946	59182675	7	55111	129	2									
FAM5C	339479	broad.mit.edu	37	chr1	190067951	190067951	+	Missense_Mutation	SNP	G	T	T																															tctgtccgttttctgcagcaGatatttcatctcgagatctt																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:190067951G>T	uc001gse.1	-	8	1730	c.1498C>A	c.(1498-1500)CTG>ATG	p.L500M	FAM5C_uc010pot.1_Missense_Mutation_p.L398M	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	500						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TTCTGCAGCAGATATTTCATC	0.493													27	102					7.41945e-09	8.46937e-09	1	0	T	190067951	T	T	190067951	3	4	298	1	0	0	0	0	1	0	0	0	5626	933	33	2	806	2	FAM5C	1	190067951	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	5	190067951	59182670	8	55112	129	2									
OR2T3	343173	broad.mit.edu	37	chr1	248637082	248637083	+	Missense_Mutation	DNP	GG	TT	TT																															cccactgctgatgaaccagaGggtgtgccagctcctggtgt																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr1:248637082_248637083GG>TT	uc001iel.1	+	1	431_432	c.431_432GG>TT	c.(430-432)AGG>ATT	p.R144I		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	144	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGAACCAGAGGGTGTGCCAGC	0.55													6	26					0	0	0	0	TT	248637083	TT	TT	248637082	3	4	298	1	0	0	0	0	1	0	0	0	11077	1000	35	4	433	4	OR2T3	1	248637082	Missense_Mutation	DNP	GG	TCGA-HD-7753-01A-11D-2078-08	58569131	248637082	613539	9	55113											
POMC	5443	broad.mit.edu	37	chr2	25387568	25387568	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctctccaggcaccagccaCgcacttccatggaggcctga	8	7	10	16	1	1	1	0	1	1	0	3	2	2	2	5	3	2	3	5	3	0	1	rs143923583	byFrequency	TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:25387568C>A	uc002rfy.1	-	3	337	c.74G>T	c.(73-75)CGT>CTT	p.R25L	POMC_uc002rfz.1_Missense_Mutation_p.R25L|POMC_uc002rga.1_Missense_Mutation_p.R25L	NM_001035256	NP_001030333	P01189	COLI_HUMAN	proopiomelanocortin preproprotein	25					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	GCACCAGCCACGCACTTCCAT	0.612													21	41					1.01871e-10	1.18523e-10	1	0	A	25387568	A	A	25387568	3	1	298	1	0	0	0	0	1	0	0	0	12297	536	19	3	737	3	POMC	2	25387568	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08		25387568	217811805	10	55114											
B3GNT2	10678	broad.mit.edu	37	chr2	62450518	62450518	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agagatgattgatatttggtCtcagttgcagagtgctcatt	10	15	11	5	0	2	4	2	2	1	2	3	5	2	4	0	1	2	3	0	1	1	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:62450518C>G	uc002sbs.2	+	2	1401	c.1163C>G	c.(1162-1164)TCT>TGT	p.S388C		NM_006577	NP_006568	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal	388	Lumenal (Potential).					Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			GATATTTGGTCTCAGTTGCAG	0.323													6	28					0	0	0	0	G	62450518	G	G	62450518	3	3	298	1	0	0	0	0	1	0	0	0	1259	913	32	2	1165	2	B3GNT2	2	62450518	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	37062950	62450518	180748855	11	55115											
SLC35F5	80255	broad.mit.edu	37	chr2	114476737	114476737	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gggactaaacttacctctgaAttcgatgttttctgcatata	11	15	7	8	1	2	1	0	1	2	0	3	3	2	2	1	1	3	2	1	1	6	7			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:114476737A>T	uc002tku.1	-	14	1914	c.1490T>A	c.(1489-1491)ATT>AAT	p.I497N	SLC35F5_uc002tkt.2_RNA	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	497					transport	integral to membrane					0						TTACCTCTGAATTCGATGTTT	0.333													6	30					0	0	0	0	T	114476737	T	T	114476737	3	4	298	1	0	0	0	0	1	0	0	0	14656	101	4	5	89	5	SLC35F5	2	114476737	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	52026219	114476737	128722636	12	55116											
LRP1B	53353	broad.mit.edu	37	chr2	140990803	140990803	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctattttctttggaagcagTtctttcctttcatcaacact	8	19	4	10	0	5	0	2	0	3	0	6	1	6	1	1	1	2	2	1	1	3	7			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:140990803T>A	uc002tvj.1	-	91	14724	c.13752A>T	c.(13750-13752)GAA>GAT	p.E4584D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4584	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGGAAGCAGTTCTTTCCTTT	0.328										TSP Lung(27;0.18)			7	28					0	0	0	0	A	140990803	A	A	140990803	3	1	298	1	0	0	0	0	1	0	0	0	9005	1722	60	5	51	5	LRP1B	2	140990803	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	26514066	140990803	102208570	13	55117											
RIF1	55183	broad.mit.edu	37	chr2	152276855	152276855	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cattattgcttcagaaacagCaagaaatagcatctattacg	16	11	6	8	1	2	2	1	0	1	2	2	2	2	2	0	0	5	3	0	0	7	6			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:152276855C>T	uc002txm.2	+	7	785	c.655C>T	c.(655-657)CAA>TAA	p.Q219*	RIF1_uc002txl.2_Nonsense_Mutation_p.Q219*|RIF1_uc010fnv.1_Nonsense_Mutation_p.Q183*|RIF1_uc002txn.2_Nonsense_Mutation_p.Q219*|RIF1_uc002txo.2_Nonsense_Mutation_p.Q219*|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	219					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TCAGAAACAGCAAGAAATAGC	0.413													4	30					0	0	0	0	T	152276855	T	T	152276855	4	4	298	1	0	0	0	0	0	1	0	0	13424	711	25	4	677	4	RIF1	2	152276855	Nonsense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	11286052	152276855	90922518	14	55118											
GALNT13	114805	broad.mit.edu	37	chr2	155252510	155252510	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaaaaattccaggtgttgtCaaagtggattatggagatgt	13	13	12	3	0	1	2	1	1	0	1	2	4	2	3	1	3	0	1	1	3	4	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:155252510C>T	uc002tyr.3	+	10	1731	c.1164C>T	c.(1162-1164)GTC>GTT	p.V388V	GALNT13_uc002tyt.3_Silent_p.V388V|GALNT13_uc010foc.1_Silent_p.V207V|GALNT13_uc010fod.2_Silent_p.V141V	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	388	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CAGGTGTTGTCAAAGTGGATT	0.353													8	12					0	0	0	0	T	155252510	T	T	155252510	2	4	298	1	0	0	0	0	0	0	0	1	6246	813	29	2		2	GALNT13	2	155252510	Silent	SNP	C	TCGA-HD-7753-01A-11D-2078-08	2975655	155252510	87946863	15	55119											
CD28	940	broad.mit.edu	37	chr2	204591669	204591669	+	Frame_Shift_Del	DEL	C	-	-																															gttatgtatcctcctccttaCctagacaatgagaagagcaa																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:204591669delC	uc002vah.3	+	2	588	c.366delC	c.(364-366)TACfs	p.Y122fs	CD28_uc002vag.1_Intron|CD28_uc010zio.1_Intron|CD28_uc010ftx.2_Intron|CD28_uc002vaj.3_Intron	NM_006139	NP_006130	P10747	CD28_HUMAN	CD28 antigen precursor	122	Extracellular (Potential).|Ig-like V-type.				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity				0						CTCCTCCTTACCTAGACAATG	0.368													---	---	---								-	204591669	-	-	204591669	7	5	298	1	0	1	0	1	0	0	0	0	3008	518	18	0	372	0	CD28	2	204591669	Frame_Shift_Del	DEL	C	TCGA-HD-7753-01A-11D-2078-08	49339159	204591669	38607704	16	55120											
ARMC9	80210	broad.mit.edu	37	chr2	232079577	232079577	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatttgacaacggagacCagaaggtgttcttcgatctg	10	11	11	9	2	2	3	0	1	2	2	3	5	2	3	1	2	2	2	1	2	2	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr2:232079577C>T	uc002vrq.3	+	4	323	c.211C>T	c.(211-213)CAG>TAG	p.Q71*	ARMC9_uc002vrp.3_Nonsense_Mutation_p.Q71*	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	71							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		CAACGGAGACCAGAAGGTGTT	0.463													11	28					0	0	0	0	T	232079577	T	T	232079577	4	4	298	1	0	0	0	0	0	1	0	0	960	595	21	4	221	4	ARMC9	2	232079577	Nonsense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	27487908	232079577	11119796	17	55121											
LOC401052	401052	broad.mit.edu	37	chr3	10049172	10049172	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctagtgtggcattggcctttCtgcttcgatggtttcttctt	3	19	10	9	1	3	0	0	0	3	0	4	1	3	0	1	3	1	3	1	3	1	7			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr3:10049172C>G	uc003bur.1	-	4	827	c.213G>C	c.(211-213)CAG>CAC	p.Q71H	CIDEC_uc003bto.2_Intron	NM_001008737	NP_001008737	B3KMQ7	B3KMQ7_HUMAN	hypothetical protein LOC401052	71											0						ATTGGCCTTTCTGCTTCGATG	0.582													37	54					0	0	0	0	G	10049172	G	G	10049172	3	3	298	1	0	0	0	0	1	0	0	0	8926	912	32	2	147	2	LOC401052	3	10049172	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08		10049172	187973258	18	55122											
PLCL2	23228	broad.mit.edu	37	chr3	17052602	17052602	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatgttactgacgaagatgaAggagcagaaatgtctcagag	15	8	13	5	1	1	5	1	2	1	3	2	8	1	6	0	1	2	2	0	1	4	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr3:17052602A>C	uc011awc.1	+	5	1845	c.1740A>C	c.(1738-1740)GAA>GAC	p.E580D	PLCL2_uc011awd.1_Missense_Mutation_p.E462D	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	588					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						ACGAAGATGAAGGAGCAGAAA	0.433													10	9					0	0	0	0	C	17052602	C	C	17052602	3	2	298	1	0	0	0	0	1	0	0	0	12095	69	3	5	1764	5	PLCL2	3	17052602	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	7003430	17052602	180969828	19	55123											
UPK1B	7348	broad.mit.edu	37	chr3	118905597	118905597	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaaatcccgaagatggccaaAgacaactcaactgttcgttg	14	8	9	10	2	1	2	1	0	0	2	3	4	2	2	2	1	2	2	2	1	5	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr3:118905597A>T	uc003ecc.2	+	2	98	c.9A>T	c.(7-9)AAA>AAT	p.K3N	UPK1B_uc011bix.1_Intron|UPK1B_uc003ecd.2_Missense_Mutation_p.K3N	NM_006952	NP_008883	O75841	UPK1B_HUMAN	uroplakin 1B	3	Cytoplasmic (Potential).				epithelial cell differentiation	integral to membrane	structural molecule activity				0				GBM - Glioblastoma multiforme(114;0.222)		AGATGGCCAAAGACAACTCAA	0.418													25	25					0	0	0	0	T	118905597	T	T	118905597	3	4	298	1	0	0	0	0	1	0	0	0	17076	69	3	5	11	5	UPK1B	3	118905597	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	101852995	118905597	79116833	20	55124											
MFSD7	84179	broad.mit.edu	37	chr4	678633	678634	+	Frame_Shift_Ins	INS	-	A	A																															acgacgccagcagggatggtINSatagacaccgagctggggag																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:678633_678634insA	uc003gay.2	-	5	654_655	c.597_598insT	c.(595-600)TATACCfs	p.Y199fs	MFSD7_uc003gaw.2_5'UTR|MFSD7_uc003gax.2_Frame_Shift_Ins_p.Y199fs|MFSD7_uc003gaz.2_Frame_Shift_Ins_p.Y80fs|MFSD7_uc003gba.2_Frame_Shift_Ins_p.Y102fs|MFSD7_uc003gbb.1_Frame_Shift_Ins_p.Y135fs	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	199_200	Helical; (Potential).				transmembrane transport	integral to membrane					0						GCAGGGATGGTATAGACACCGA	0.683													---	---	---								A	678634	A	A	678633	7	5	298	1	0	1	1	0	0	0	0	0	9590	1638	57	0	1105	0	MFSD7	4	678633	Frame_Shift_Ins	INS	-	TCGA-HD-7753-01A-11D-2078-08		678633	190475643	21	55125											
DDX60	55601	broad.mit.edu	37	chr4	169188752	169188752	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgatctgttgttagtgcaGcacatgggtgaaaatgatca	12	12	11	6	0	2	3	1	3	1	0	2	3	2	3	0	1	2	4	0	1	3	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:169188752G>A	uc003irp.2	-	22	3312	c.3020C>T	c.(3019-3021)GCT>GTT	p.A1007V		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1007							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TGTTAGTGCAGCACATGGGTG	0.284													11	38					0	0	0	0	A	169188752	A	A	169188752	3	1	298	1	0	0	0	0	1	0	0	0	4395	971	34	4	2186	4	DDX60	4	169188752	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	168510119	169188752	21965524	22	55126											
C4orf41	60684	broad.mit.edu	37	chr4	184626159	184626159	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaatggagaatatccccatCatcacaactgtcatcactct	13	10	5	13	0	5	1	4	0	1	1	6	2	6	1	2	1	1	1	2	1	4	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:184626159C>A	uc003ivx.2	+	27	3167	c.2991C>A	c.(2989-2991)ATC>ATA	p.I997I	C4orf41_uc003ivw.2_Silent_p.I997I|C4orf41_uc010isc.2_Silent_p.I341I|C4orf41_uc003ivy.2_Silent_p.I603I	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	997											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		ATATCCCCATCATCACAACTG	0.358													35	85					2.95478e-19	3.72425e-19	1	0	A	184626159	A	A	184626159	2	1	298	1	0	0	0	0	0	0	0	1	2280	816	29	2		2	C4orf41	4	184626159	Silent	SNP	C	TCGA-HD-7753-01A-11D-2078-08	15437407	184626159	6528117	23	55127											
SORBS2	8470	broad.mit.edu	37	chr4	186545478	186545478	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgtgctgctccagatttctgCgttttgccgggccatttgcc	3	14	11	13	3	1	1	0	0	1	1	2	1	2	1	4	1	5	3	4	1	0	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:186545478C>A	uc003iyl.2	-	13	1951	c.1093G>T	c.(1093-1095)GCA>TCA	p.A365S	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.A465S|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.A269S|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.A479S|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	365						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CAGATTTCTGCGTTTTGCCGG	0.522													19	52					2.37509e-13	2.84541e-13	1	0	A	186545478	A	A	186545478	3	1	298	1	0	0	0	0	1	0	0	0	14992	768	27	3	2245	3	SORBS2	4	186545478	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	1919319	186545478	4608798	24	55128											
KLKB1	3818	broad.mit.edu	37	chr4	187179174	187179174	+	Splice_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tatttttccactgtgactcaGggagattcaggtggtccctt	7	15	10	9	0	2	2	2	1	0	1	4	3	4	2	2	3	0	0	2	3	1	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr4:187179174G>T	uc003iyy.2	+	15	1797	c.1726_splice	c.e15-1	p.G576_splice	KLKB1_uc011clc.1_Splice_Site_p.G374_splice|KLKB1_uc011cld.1_Splice_Site_p.G491_splice	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor						blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		CTGTGACTCAGGGAGATTCAG	0.478													16	43					1.99824e-07	2.17826e-07	1	0	T	187179174	T	T	187179174	5	4	298	1	0	0	0	0	0	0	1	0	8451	1014	35	4	1779	4	KLKB1	4	187179174	Splice_Site	SNP	G	TCGA-HD-7753-01A-11D-2078-08	633696	187179174	3975102	25	55129											
IRX1	79192	broad.mit.edu	37	chr5	3601102	3601102	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgtttcccatgcagctctcTggccccgcaggagggaacgc	6	8	13	14	2	1	0	0	0	1	0	3	2	2	2	3	3	3	4	3	3	1	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:3601102T>C	uc003jde.2	+	4	1443	c.1391T>C	c.(1390-1392)CTG>CCG	p.L464P		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	464						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						TGCAGCTCTCTGGCCCCGCAG	0.662													14	53					0	0	0	0	C	3601102	C	C	3601102	3	2	298	1	0	0	0	0	1	0	0	0	7882	1580	55	5	1405	5	IRX1	5	3601102	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08		3601102	177314158	26	55130											
PRDM9	56979	broad.mit.edu	37	chr5	23522415	23522415	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tactcttctccaacctagaaCtcaggaagaaggagactgaa	15	8	8	10	0	3	4	1	1	2	3	4	6	3	5	2	2	3	0	2	2	7	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:23522415C>G	uc003jgo.2	+	7	693	c.511C>G	c.(511-513)CTC>GTC	p.L171V		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	171					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CAACCTAGAACTCAGGAAGAA	0.433										HNSCC(3;0.000094)			26	93					0	0	0	0	G	23522415	G	G	23522415	3	3	298	1	0	0	0	0	1	0	0	0	12525	565	20	4	533	4	PRDM9	5	23522415	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	19921313	23522415	157392845	27	55131											
CDH10	1008	broad.mit.edu	37	chr5	24505331	24505331	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaatgttaaagattctgtcaAggtcagtatggcgatccaag	13	11	11	6	1	3	1	2	0	1	1	4	3	4	1	1	2	0	2	1	2	6	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:24505331A>T	uc003jgr.1	-	8	1615	c.1283T>A	c.(1282-1284)CTT>CAT	p.L428H	CDH10_uc011cnu.1_Intron	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	428	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GATTCTGTCAAGGTCAGTATG	0.358										HNSCC(23;0.051)			17	35					0	0	0	0	T	24505331	T	T	24505331	3	4	298	1	0	0	0	0	1	0	0	0	3111	72	3	5	1103	5	CDH10	5	24505331	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	982916	24505331	156409929	28	55132											
PDZD2	23037	broad.mit.edu	37	chr5	32098603	32098604	+	Frame_Shift_Ins	INS	-	ACAA	ACAA																															ctgaaggttctgcaccaggcINSacagctgcacaaagatgccc																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:32098603_32098604insACAA	uc003jhl.2	+	23	8469_8470	c.8081_8082insACAA	c.(8080-8082)GCAfs	p.A2694fs	PDZD2_uc003jhm.2_Frame_Shift_Ins_p.A2694fs|PDZD2_uc003jhn.2_5'Flank	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2694	PDZ 5.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CTGCACCAGGCACAGCTGCACA	0.594													---	---	---								ACAA	32098604	ACAA	ACAA	32098603	7	5	298	1	0	1	1	0	0	0	0	0	11755	710	25	0	8167	0	PDZD2	5	32098603	Frame_Shift_Ins	INS	-	TCGA-HD-7753-01A-11D-2078-08	7593272	32098603	148816657	29	55133											
PRKAA1	5562	broad.mit.edu	37	chr5	40767661	40767661	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatttaaatattgaggggtaTagaagatcccatcacatatc	15	12	8	6	0	1	3	1	1	0	2	3	4	2	3	1	2	0	1	1	2	7	7			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:40767661T>C	uc003jmc.2	-	6	734	c.728A>G	c.(727-729)TAT>TGT	p.Y243C	PRKAA1_uc003jmb.2_Missense_Mutation_p.Y258C	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	243	Protein kinase.				activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	TTGAGGGGTATAGAAGATCCC	0.388													15	79					0	0	0	0	C	40767661	C	C	40767661	3	2	298	1	0	0	0	0	1	0	0	0	12555	1406	49	5	967	5	PRKAA1	5	40767661	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	8669058	40767661	140147599	30	55134											
PCDHA3	56145	broad.mit.edu	37	chr5	140182317	140182317	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagctacgtgtcggtacacgCggagagcggcaaggtgtacg	9	6	17	9	6	0	1	0	0	0	1	1	3	0	1	0	4	5	4	0	4	4	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:140182317C>A	uc003lhf.2	+	1	1535	c.1535C>A	c.(1534-1536)GCG>GAG	p.A512E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.A512E	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	512	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGTACACGCGGAGAGCGGC	0.706													42	41					2.24893e-16	2.80537e-16	1	0	A	140182317	A	A	140182317	3	1	298	1	0	0	0	0	1	0	0	0	11579	768	27	3	1537	3	PCDHA3	5	140182317	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	99414656	140182317	40732943	31	55135											
ZNF354C	30832	broad.mit.edu	37	chr5	178505981	178505981	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cacacaacagagtgttcctaTagaaaggatacccaatatgt	16	9	7	9	0	0	2	0	0	0	2	1	3	1	3	2	1	2	1	2	1	7	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr5:178505981T>C	uc003mju.2	+	5	663	c.548T>C	c.(547-549)ATA>ACA	p.I183T		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	183					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		AGTGTTCCTATAGAAAGGATA	0.358													18	19					0	0	0	0	C	178505981	C	C	178505981	3	2	298	1	0	0	0	0	1	0	0	0	17933	1406	49	5	562	5	ZNF354C	5	178505981	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	38323664	178505981	2409279	32	55136											
CAPN11	11131	broad.mit.edu	37	chr6	44148689	44148702	+	Frame_Shift_Del	DEL	GGGCTTTGGCCTGG	-	-																															gtcaaaagcttcaagaccaaGggctttggcctggatgcttg																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr6:44148689_44148702delGGGCTTTGGCCTGG	uc003owt.1	+	18	1862_1875	c.1824_1837delGGGCTTTGGCCTGG	c.(1822-1839)AAGGGCTTTGGCCTGGATfs	p.K608fs	CAPN11_uc011dvn.1_Frame_Shift_Del_p.K262fs	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	608_613	EF-hand 1.|Domain IV.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCAAGACCAAGGGCTTTGGCCTGGATGCTTGCCG	0.57													---	---	---								-	44148702	-	-	44148689	7	5	298	1	0	1	0	1	0	0	0	0	2636	991	35	0	1894	0	CAPN11	6	44148689	Frame_Shift_Del	DEL	GGGCTTTGGCCTGG	TCGA-HD-7753-01A-11D-2078-08		44148689	126966378	33	55137											
FAM83B	222584	broad.mit.edu	37	chr6	54804723	54804723	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tcattagcatctgtttccagCcagagaaacctttttggtag	10	14	8	9	0	2	1	1	0	1	1	3	2	3	1	3	1	3	3	3	1	3	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr6:54804723C>G	uc003pck.2	+	5	1070	c.954C>G	c.(952-954)AGC>AGG	p.S318R		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	318										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					CTGTTTCCAGCCAGAGAAACC	0.388													19	47					0	0	0	0	G	54804723	G	G	54804723	3	3	298	1	0	0	0	0	1	0	0	0	5666	738	26	4	968	4	FAM83B	6	54804723	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	10656034	54804723	116310344	34	55138											
ABCA13	154664	broad.mit.edu	37	chr7	48318540	48318540	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaaatagatcatttcacAtttgaaaagataaatgattt	21	13	4	3	0	2	4	2	2	0	2	2	4	2	4	0	0	0	0	0	0	8	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:48318540A>G	uc003toq.2	+	18	7774	c.7749A>G	c.(7747-7749)ACA>ACG	p.T2583T	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2583					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ATCATTTCACATTTGAAAAGA	0.308													29	45					0	0	0	0	G	48318540	G	G	48318540	2	3	298	1	0	0	0	0	0	0	0	1	31	204	8	5		5	ABCA13	7	48318540	Silent	SNP	A	TCGA-HD-7753-01A-11D-2078-08		48318540	110820123	35	55139											
PARP12	64761	broad.mit.edu	37	chr7	139737556	139737556	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtgctttccggcctggaacTtcaaggtggctgcctggccg	4	11	14	12	2	1	0	1	0	0	0	2	1	2	1	4	5	3	2	4	5	2	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:139737556T>C	uc003vvl.1	-	7	2157	c.1283A>G	c.(1282-1284)AAG>AGG	p.K428R	PARP12_uc003vvk.1_Missense_Mutation_p.K214R|PARP12_uc010lnf.1_Intron	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	428	WWE 2.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					GGCCTGGAACTTCAAGGTGGC	0.602													11	26					0	0	0	0	C	139737556	C	C	139737556	3	2	298	1	0	0	0	0	1	0	0	0	11511	1609	56	5	846	5	PARP12	7	139737556	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	91419016	139737556	19401107	36	55140											
OR2A2	442361	broad.mit.edu	37	chr7	143806912	143806912	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttccaacaatgttcccaaGatgttggcaaacctaatgaa	14	10	7	10	0	0	2	0	1	0	1	2	2	2	2	3	1	2	4	3	1	6	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:143806912G>T	uc011ktz.1	+	1	237	c.237G>T	c.(235-237)AAG>AAT	p.K79N		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					ATGTTCCCAAGATGTTGGCAA	0.433													27	152					4.72057e-08	5.19263e-08	1	0	T	143806912	T	T	143806912	3	4	298	1	0	0	0	0	1	0	0	0	11031	933	33	2	239	2	OR2A2	7	143806912	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	4069356	143806912	15331751	37	55141											
CNTNAP2	26047	broad.mit.edu	37	chr7	146825855	146825855	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaagaatttcaaaggctgcaTggaaagcatcaactacaatg	18	8	8	7	0	2	1	2	0	0	1	2	2	2	2	0	2	4	3	0	2	7	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:146825855T>G	uc003weu.1	+	7	1526	c.1010T>G	c.(1009-1011)ATG>AGG	p.M337R		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	337	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAAGGCTGCATGGAAAGCATC	0.408										HNSCC(39;0.1)			40	70					0	0	0	0	G	146825855	G	G	146825855	3	3	298	1	0	0	0	0	1	0	0	0	3662	1464	51	5	1036	5	CNTNAP2	7	146825855	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	3018943	146825855	12312808	38	55142											
SMARCD3	6604	broad.mit.edu	37	chr7	150936506	150936506	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagtagaagtagcgactgacGgcctcctgggaccagggctg	9	6	15	11	2	0	2	0	1	0	1	1	4	1	3	3	3	1	3	3	3	3	2	rs139287814		TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:150936506G>A	uc003wjs.2	-	12	1475	c.1374C>T	c.(1372-1374)GCC>GCT	p.A458A	SMARCD3_uc003wjt.2_Silent_p.A445A|SMARCD3_uc003wju.2_Silent_p.A445A	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	458					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCGACTGACGGCCTCCTGGG	0.612													12	34					0	0	0	0	A	150936506	A	A	150936506	2	1	298	1	0	0	0	0	0	0	0	1	14843	1103	39	1		1	SMARCD3	7	150936506	Silent	SNP	G	TCGA-HD-7753-01A-11D-2078-08	4110651	150936506	8202157	39	55143											
DPP6	1804	broad.mit.edu	37	chr7	154585880	154585880	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacgtgtccatcctcaccCtctgcgacgccaccacgggg	8	6	10	17	4	2	1	1	0	1	1	4	2	4	1	5	2	2	0	5	2	1	0			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr7:154585880C>G	uc003wlk.2	+	11	1357	c.1228C>G	c.(1228-1230)CTC>GTC	p.L410V	DPP6_uc003wli.2_Missense_Mutation_p.L346V|DPP6_uc003wlm.2_Missense_Mutation_p.L348V|DPP6_uc011kvq.1_Missense_Mutation_p.L303V	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	410	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CATCCTCACCCTCTGCGACGC	0.657													4	10					0	0	0	0	G	154585880	G	G	154585880	3	3	298	1	0	0	0	0	1	0	0	0	4752	681	24	4	1386	4	DPP6	7	154585880	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	3649374	154585880	4552783	40	55144											
CSMD1	64478	broad.mit.edu	37	chr8	2832027	2832027	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcttcctggcacactctcgTgtcgttgcctatgaggctct	4	14	10	13	2	3	1	0	1	3	0	6	1	4	1	2	2	1	3	2	2	1	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr8:2832027T>C	uc011kwk.1	-	56	9079	c.8689A>G	c.(8689-8691)ACG>GCG	p.T2897A	CSMD1_uc011kwj.1_Missense_Mutation_p.T2226A|CSMD1_uc010lrg.2_Missense_Mutation_p.T907A	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2897	Sushi 21.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CACACTCTCGTGTCGTTGCCT	0.572													5	8					0	0	0	0	C	2832027	C	C	2832027	3	2	298	1	0	0	0	0	1	0	0	0	3961	1696	59	5	2068	5	CSMD1	8	2832027	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08		2832027	143531995	41	55145											
CYP7A1	1581	broad.mit.edu	37	chr8	59409370	59409370	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tctctgccagtttctcccggGcattgtgcgcagtcctgaac	5	12	10	14	2	2	1	0	1	2	0	5	1	3	1	3	1	3	3	3	1	1	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr8:59409370G>T	uc003xtm.3	-	3	764	c.701C>A	c.(700-702)GCC>GAC	p.A234D		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	234					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TTTCTCCCGGGCATTGTGCGC	0.488									Neonatal_Giant_Cell_Hepatitis				20	76					1.15919e-05	1.24125e-05	1	0	T	59409370	T	T	59409370	3	4	298	1	0	0	0	0	1	0	0	0	4213	1203	42	4	829	4	CYP7A1	8	59409370	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	56577343	59409370	86954652	42	55146											
TRHR	7201	broad.mit.edu	37	chr8	110131301	110131301	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccaagatgctggcagtggttGtaattctgtttgccctttta	7	16	10	8	0	1	1	0	0	1	1	1	1	1	1	2	2	2	5	2	2	3	6			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr8:110131301G>T	uc003ymz.3	+	2	830	c.814G>T	c.(814-816)GTA>TTA	p.V272L		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	272	Helical; Name=6; (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity	p.V272A(1)		skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GGCAGTGGTTGTAATTCTGTT	0.413													152	134					3.54725e-78	4.61523e-78	1	0	T	110131301	T	T	110131301	3	4	298	1	0	0	0	0	1	0	0	0	16547	1377	48	4	820	4	TRHR	8	110131301	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	50721931	110131301	36232721	43	55147											
CSMD3	114788	broad.mit.edu	37	chr8	113569097	113569119	+	Frame_Shift_Del	DEL	TGGTGCTACCAGCAAAGTGGCCT	-	-																															tggattgcatccataaatgaTggtgctaccagcaaagtggc																								rs143731892	byFrequency	TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr8:113569097_113569119delTGGTGCTACCAGCAAAGTGGCCT	uc003ynu.2	-	25	4266_4288	c.4107_4129delAGGCCACTTTGCTGGTAGCACCA	c.(4105-4131)CAAGGCCACTTTGCTGGTAGCACCATCfs	p.Q1369fs	CSMD3_uc003yns.2_Frame_Shift_Del_p.Q641fs|CSMD3_uc003ynt.2_Frame_Shift_Del_p.Q1329fs|CSMD3_uc011lhx.1_Frame_Shift_Del_p.Q1265fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1369_1377	Extracellular (Potential).|Sushi 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCATAAATGATGGTGCTACCAGCAAAGTGGCCTTGGTCACTGA	0.453										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---								-	113569119	-	-	113569097	7	5	298	1	0	1	0	1	0	0	0	0	3963	1464	51	0	7182	0	CSMD3	8	113569097	Frame_Shift_Del	DEL	TGGTGCTACCAGCAAAGTGGCCT	TCGA-HD-7753-01A-11D-2078-08	3437796	113569097	32794925	44	55148											
KDM4C	23081	broad.mit.edu	37	chr9	6986506	6986506	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcagacccatccgagctttCatggccaaagtcacctgagt	11	9	8	13	1	3	2	3	1	0	1	4	3	4	2	4	1	1	1	4	1	1	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr9:6986506C>T	uc003zkh.2	+	11	2097	c.1517C>T	c.(1516-1518)TCA>TTA	p.S506L	KDM4C_uc010mhu.2_Missense_Mutation_p.S528L|KDM4C_uc011lmi.1_Missense_Mutation_p.S506L|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.S506L|KDM4C_uc011lmk.1_Missense_Mutation_p.S325L|KDM4C_uc011lml.1_Missense_Mutation_p.S193L	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	506					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						TCCGAGCTTTCATGGCCAAAG	0.478													17	24					0	0	0	0	T	6986506	T	T	6986506	3	4	298	1	0	0	0	0	1	0	0	0	8169	838	29	2	1625	2	KDM4C	9	6986506	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08		6986506	134226925	45	55149											
VPS13A	23230	broad.mit.edu	37	chr9	79898351	79898351	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtttacagatctttattcaaGatcagaaatgtaacatttct	14	16	5	6	0	4	3	2	0	2	3	4	3	4	3	0	0	2	2	0	0	5	7			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr9:79898351G>C	uc004akr.2	+	30	3459	c.3199G>C	c.(3199-3201)GAT>CAT	p.D1067H	VPS13A_uc004akp.3_Missense_Mutation_p.D1067H|VPS13A_uc004akq.3_Missense_Mutation_p.D1067H|VPS13A_uc004aks.2_Intron	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1067					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						CTTTATTCAAGATCAGAAATG	0.254													10	10					0	0	0	0	C	79898351	C	C	79898351	3	2	298	1	0	0	0	0	1	0	0	0	17257	942	33	2	3317	2	VPS13A	9	79898351	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	72911845	79898351	61315080	46	55150											
KIF27	55582	broad.mit.edu	37	chr9	86518343	86518343	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	caaagcttctcgaagcaattTaatctcaaattccatttcat	14	14	3	10	1	3	0	2	0	2	0	6	1	4	0	1	0	2	2	1	0	5	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr9:86518343T>G	uc004ana.2	-	4	1234	c.1090A>C	c.(1090-1092)AAA>CAA	p.K364Q	KIF27_uc010mpw.2_Missense_Mutation_p.K364Q|KIF27_uc010mpx.2_Missense_Mutation_p.K364Q	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	364	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						CGAAGCAATTTAATCTCAAAT	0.433													19	57					0	0	0	0	G	86518343	G	G	86518343	3	3	298	1	0	0	0	0	1	0	0	0	8335	1763	61	5	3175	5	KIF27	9	86518343	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	6619992	86518343	54695088	47	55151											
SAMD8	142891	broad.mit.edu	37	chr10	76910800	76910800	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttacatctttcattatggttAtagtccatgagcgagtgcct	9	16	8	8	1	2	1	1	1	1	0	3	2	3	1	2	1	3	1	2	1	4	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr10:76910800A>G	uc001jwx.1	+	2	617	c.514A>G	c.(514-516)ATA>GTA	p.I172V	SAMD8_uc001jwy.1_Missense_Mutation_p.I172V	NM_144660	NP_653261	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	172	Helical; (Potential).				sphingomyelin biosynthetic process	integral to membrane					0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CATTATGGTTATAGTCCATGA	0.368													3	31					0	0	0	0	G	76910800	G	G	76910800	3	3	298	1	0	0	0	0	1	0	0	0	13890	449	16	5	516	5	SAMD8	10	76910800	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08		76910800	58623947	48	55152											
RAB11FIP2	22841	broad.mit.edu	37	chr10	119798612	119798612	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agtcacaagggctatcagatCccccattgttaagtttatca	12	12	7	10	0	3	1	3	0	0	1	4	1	4	1	2	1	0	3	2	1	4	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr10:119798612C>T	uc001ldj.1	-	3	1576	c.1136G>A	c.(1135-1137)GGA>GAA	p.G379E	RAB11FIP2_uc009xyz.1_Missense_Mutation_p.G379E	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	379					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		GCTATCAGATCCCCCATTGTT	0.353													10	73					0	0	0	0	T	119798612	T	T	119798612	3	4	298	1	0	0	0	0	1	0	0	0	12959	855	30	2	414	2	RAB11FIP2	10	119798612	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	42887812	119798612	15736135	49	55153											
FAM53B	9679	broad.mit.edu	37	chr10	126370453	126370453	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ggtgcaggtcagggctccagGtgtcacctgcctgtccacac	6	8	13	14	0	2	0	2	0	0	0	4	0	4	0	4	4	2	2	4	4	0	0			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr10:126370453G>C	uc001lhv.1	-	4	1152	c.629C>G	c.(628-630)ACC>AGC	p.T210S	FAM53B_uc001lhu.1_Missense_Mutation_p.T210S|FAM53B_uc001lhw.2_Missense_Mutation_p.T210S	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	210										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		AGGGCTCCAGGTGTCACCTGC	0.642													2	9					0	0	0	0	C	126370453	C	C	126370453	3	2	298	1	0	0	0	0	1	0	0	0	5612	1261	44	4	647	4	FAM53B	10	126370453	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	6571841	126370453	9164294	50	55154											
LGR4	55366	broad.mit.edu	37	chr11	27390526	27390527	+	Frame_Shift_Ins	INS	-	AGAAATCA	AGAAATCA																															cccatgaataagttagacacINSagaaatcaagcctataaaca																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:27390526_27390527insAGAAATCA	uc001mrj.3	-	18	2228_2229	c.1743_1744insTGATTTCT	c.(1741-1746)TCTGTGfs	p.S581fs	LGR4_uc001mrk.3_Frame_Shift_Ins_p.S557fs	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	581_582	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						AAGTTAGACACAGAAATCAAGC	0.386													---	---	---								AGAAATCA	27390527	AGAAATCA	AGAAATCA	27390526	7	5	298	1	0	1	1	0	0	0	0	0	8797	478	17	0	1115	0	LGR4	11	27390526	Frame_Shift_Ins	INS	-	TCGA-HD-7753-01A-11D-2078-08		27390526	107615990	51	55155											
FOLH1	2346	broad.mit.edu	37	chr11	49227672	49227672	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcatccaaaaatgctttcatAttatgctttggagtaatgtt	12	17	6	6	0	2	0	2	0	0	0	3	1	3	1	1	1	2	4	1	1	5	6			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:49227672A>G	uc001ngy.2	-	2	432	c.171T>C	c.(169-171)AAT>AAC	p.N57N	FOLH1_uc001ngz.2_Silent_p.N57N|FOLH1_uc009yly.2_Silent_p.N42N|FOLH1_uc009ylz.2_Silent_p.N42N|FOLH1_uc009yma.2_5'UTR|FOLH1_uc001nha.2_Silent_p.N42N	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	57	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	ATGCTTTCATATTATGCTTTG	0.323													14	26					0	0	0	0	G	49227672	G	G	49227672	2	3	298	1	0	0	0	0	0	0	0	1	6011	446	16	5		5	FOLH1	11	49227672	Silent	SNP	A	TCGA-HD-7753-01A-11D-2078-08	21837146	49227672	85778844	52	55156											
DAGLA	747	broad.mit.edu	37	chr11	61511763	61511763	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcccccacggctctttgcCggctcagccgacccctcctc	5	7	8	21	3	2	0	1	0	1	0	4	1	3	0	7	2	3	2	7	2	1	1	rs145101853		TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:61511763C>G	uc001nsa.2	+	20	3042	c.2931C>G	c.(2929-2931)GCC>GCG	p.A977A		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	977	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GGCTCTTTGCCGGCTCAGCCG	0.677													21	55					0	0	0	0	G	61511763	G	G	61511763	2	3	298	1	0	0	0	0	0	0	0	1	4243	639	23	3		3	DAGLA	11	61511763	Silent	SNP	C	TCGA-HD-7753-01A-11D-2078-08	12284091	61511763	73494753	53	55157											
B3GNT1	11041	broad.mit.edu	37	chr11	66113556	66113556	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagttggggtacttggccttCaactcctgtttgaactggcg	6	13	13	9	1	1	1	1	1	0	0	2	2	2	1	2	4	3	3	2	4	3	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:66113556C>G	uc001ohr.2	-	2	1357	c.1212G>C	c.(1210-1212)TTG>TTC	p.L404F	BRMS1_uc001ohp.1_5'Flank|BRMS1_uc001oho.1_5'Flank	NM_006876	NP_006867	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal	404	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity				0						ACTTGGCCTTCAACTCCTGTT	0.512													24	110					0	0	0	0	G	66113556	G	G	66113556	3	3	298	1	0	0	0	0	1	0	0	0	1258	825	29	2	39	2	B3GNT1	11	66113556	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	4601793	66113556	68892960	54	55158											
FAM55B	120406	broad.mit.edu	37	chr11	114568901	114568901	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaataaaggacattatggaGaaactagaccagcagatccc	18	6	9	8	0	0	4	0	0	0	4	1	6	1	5	2	2	2	1	2	2	6	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:114568901G>T	uc009yyy.2	+	3	365	c.267G>T	c.(265-267)GAG>GAT	p.E89D		NM_182495	NP_872301	Q96DL1	FA55B_HUMAN	hypothetical protein LOC120406	89						integral to membrane				ovary(1)	1						ACATTATGGAGAAACTAGACC	0.458													15	23					5.35267e-07	5.78279e-07	1	0	T	114568901	T	T	114568901	3	4	298	1	0	0	0	0	1	0	0	0	5617	933	33	2	277	2	FAM55B	11	114568901	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	48455345	114568901	20437615	55	55159											
VWA5A	4013	broad.mit.edu	37	chr11	124007741	124007741	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcctcaccattcaccgccttGctgccaagtccttgctccag	6	10	7	18	1	2	0	2	0	0	0	4	0	4	0	7	0	3	2	7	0	1	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr11:124007741G>T	uc001pzu.2	+	15	1854	c.1645G>T	c.(1645-1647)GCT>TCT	p.A549S	VWA5A_uc001pzt.2_Missense_Mutation_p.A549S	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	549										upper_aerodigestive_tract(1)|ovary(1)	2						TCACCGCCTTGCTGCCAAGTC	0.453													23	30					2.44723e-14	3.02158e-14	1	0	T	124007741	T	T	124007741	3	4	298	1	0	0	0	0	1	0	0	0	17310	1319	46	4	1699	4	VWA5A	11	124007741	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	9438840	124007741	10998775	56	55160											
CD163	9332	broad.mit.edu	37	chr12	7639150	7639150	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caattttgctgcccccagccGtgtgaatggcactgccaaat	9	10	9	13	1	0	1	0	1	0	0	0	1	0	1	4	1	4	2	4	1	3	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:7639150G>A	uc001qsz.3	-	10	2531	c.2403C>T	c.(2401-2403)CAC>CAT	p.H801H	CD163_uc001qta.3_Silent_p.H801H|CD163_uc009zfw.2_Silent_p.H834H	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	801	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GCCCCCAGCCGTGTGAATGGC	0.483													46	114					0	0	0	0	A	7639150	A	A	7639150	2	1	298	1	0	0	0	0	0	0	0	1	2982	1136	40	1		1	CD163	12	7639150	Silent	SNP	G	TCGA-HD-7753-01A-11D-2078-08		7639150	126212745	57	55161											
TMEM117	84216	broad.mit.edu	37	chr12	44605082	44605082	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cattgcttcaggtcactgatAtgatgcttcaggacaaaccc	11	11	8	11	0	3	2	3	2	0	0	3	3	3	3	1	2	3	2	1	2	2	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:44605082A>G	uc001rod.2	+	5	586	c.520A>G	c.(520-522)ATG>GTG	p.M174V	TMEM117_uc001roe.2_Missense_Mutation_p.M70V|TMEM117_uc009zkc.2_Missense_Mutation_p.M174V	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	174	Helical; (Potential).					endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		GGTCACTGATATGATGCTTCA	0.353													14	49					0	0	0	0	G	44605082	G	G	44605082	3	3	298	1	0	0	0	0	1	0	0	0	16097	449	16	5	534	5	TMEM117	12	44605082	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	36965932	44605082	89246813	58	55162											
ATF7	11016	broad.mit.edu	37	chr12	53994854	53994854	+	5'Flank	DEL	A	-	-																															tatgttaaatatgctggagcAaaaaaaaaaaaaaagtgctt																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:53994854delA	uc001sdy.2	-						ATF7_uc010sok.1_Intron|ATF7_uc001sdz.2_Intron|ATF7_uc010sol.1_Intron|ATF7_uc001sea.3_Intron|ATF7_uc001seb.3_Intron	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1						interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						ATGCTGGAGCAAAAAAAAAAA	0.418													---	---	---								-	53994854	-	-	53994854	6	5	298	0	1	1	0	1	0	0	0	0	1088	145	5	0		0	ATF7	12	53994854	5'Flank	DEL	A	TCGA-HD-7753-01A-11D-2078-08	9389772	53994854	79857041	59	55163											
ERBB3	2065	broad.mit.edu	37	chr12	56481413	56481413	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgctggggtcctggatcagaAgactgccagacatgtgggtt	8	10	15	8	0	1	3	1	0	0	3	2	4	2	4	2	4	2	2	2	4	1	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:56481413A>T	uc001sjh.2	+	5	793	c.600A>T	c.(598-600)GAA>GAT	p.E200D	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.E141D|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	200	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CTGGATCAGAAGACTGCCAGA	0.552													20	42					0	0	0	0	T	56481413	T	T	56481413	3	4	298	1	0	0	0	0	1	0	0	0	5232	69	3	5	749	5	ERBB3	12	56481413	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	2486559	56481413	77370482	60	55164											
MED13L	23389	broad.mit.edu	37	chr12	116421091	116421091	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ggtagtgcttatctggctaaTaccaggagcagaggcagacg	11	8	14	8	1	1	2	0	0	1	2	1	3	1	3	1	4	3	5	1	4	4	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:116421091T>C	uc001tvw.2	-	21	4841	c.4786A>G	c.(4786-4788)ATT>GTT	p.I1596V		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1596	Ser-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		ATCTGGCTAATACCAGGAGCA	0.512													22	37					0	0	0	0	C	116421091	C	C	116421091	3	2	298	1	0	0	0	0	1	0	0	0	9484	1406	49	5	1890	5	MED13L	12	116421091	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	59939678	116421091	17430804	61	55165											
GCN1L1	10985	broad.mit.edu	37	chr12	120584869	120584869	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctaccttctggtctgtcAgggagtacatgttgccaata	8	12	10	11	1	3	0	1	0	2	0	3	1	3	1	3	2	3	3	3	2	4	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:120584869A>C	uc001txo.2	-	38	4947	c.4934T>G	c.(4933-4935)CTG>CGG	p.L1645R		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1645	HEAT 11.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTGGTCTGTCAGGGAGTACAT	0.557													9	15					0	0	0	0	C	120584869	C	C	120584869	3	2	298	1	0	0	0	0	1	0	0	0	6334	188	7	5	3165	5	GCN1L1	12	120584869	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	4163778	120584869	13267026	62	55166											
KNTC1	9735	broad.mit.edu	37	chr12	123095404	123095404	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgtctcgtccaattgattAtagttcaagaatgctgtttg	9	16	8	8	1	2	2	1	1	1	1	4	2	3	2	2	0	1	3	2	0	5	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr12:123095404A>G	uc001ucv.2	+	53	5742	c.5579A>G	c.(5578-5580)TAT>TGT	p.Y1860C	KNTC1_uc010taf.1_Missense_Mutation_p.Y785C	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1860					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CCAATTGATTATAGTTCAAGA	0.328													12	24					0	0	0	0	G	123095404	G	G	123095404	3	3	298	1	0	0	0	0	1	0	0	0	8467	449	16	5	5785	5	KNTC1	12	123095404	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	2510535	123095404	10756491	63	55167											
MTUS2	23281	broad.mit.edu	37	chr13	29600957	29600957	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cagacctgcagaagccaaggGtcttcagttccggattgatg	10	9	12	10	1	2	3	1	1	1	2	3	4	3	4	3	2	2	2	3	2	2	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr13:29600957G>A	uc001usl.3	+	1	2210	c.2152G>A	c.(2152-2154)GTC>ATC	p.V718I		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	708	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						GAAGCCAAGGGTCTTCAGTTC	0.493													14	29					0	0	0	0	A	29600957	A	A	29600957	3	1	298	1	0	0	0	0	1	0	0	0	10019	1261	44	4	2154	4	MTUS2	13	29600957	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08		29600957	85568921	64	55168											
SPG20	23111	broad.mit.edu	37	chr13	36909740	36909740	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctttcattttctgttgcatCtgtctagcagattcccaccc	6	17	5	13	0	5	1	1	0	4	1	6	1	6	1	2	0	2	3	2	0	1	6			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr13:36909740C>A	uc001uvn.2	-	3	498	c.228G>T	c.(226-228)CAG>CAT	p.Q76H	SPG20_uc010ten.1_Missense_Mutation_p.Q76H|SPG20_uc001uvm.2_Missense_Mutation_p.Q76H|SPG20_uc001uvo.2_Missense_Mutation_p.Q76H|SPG20_uc001uvq.2_Missense_Mutation_p.Q76H|SPG20_uc001uvp.2_Missense_Mutation_p.Q76H	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin	76	MIT.				cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		TCTGTTGCATCTGTCTAGCAG	0.453													26	27					9.57634e-11	1.12499e-10	1	0	A	36909740	A	A	36909740	3	1	298	1	0	0	0	0	1	0	0	0	15108	912	32	2	1804	2	SPG20	13	36909740	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	7308783	36909740	78260138	65	55169											
PCDH8	5100	broad.mit.edu	37	chr13	53421763	53421763	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccctcgtcggggtcggctGcgtccaggtcgagaagcagg	5	7	17	12	5	0	1	0	0	0	1	6	2	2	1	2	5	2	2	2	5	1	0			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr13:53421763G>C	uc001vhi.2	-	1	1012	c.809C>G	c.(808-810)GCA>GGA	p.A270G	PCDH8_uc001vhj.2_Missense_Mutation_p.A270G	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	270	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GGGGTCGGCTGCGTCCAGGTC	0.711													2	1					0	0	0	0	C	53421763	C	C	53421763	3	2	298	1	0	0	0	0	1	0	0	0	11571	1319	46	4	2415	4	PCDH8	13	53421763	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	16512023	53421763	61748115	66	55170											
SLITRK5	26050	broad.mit.edu	37	chr13	88328847	88328847	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	agcgaaagatcgagagcatcGctgaactgcagcccaagccc	13	4	11	13	3	0	3	0	1	0	2	2	5	0	3	2	0	6	3	2	0	3	0			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr13:88328847G>T	uc001vln.2	+	2	1423	c.1204G>T	c.(1204-1206)GCT>TCT	p.A402S	SLITRK5_uc010tic.1_Missense_Mutation_p.A161S	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	402	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CGAGAGCATCGCTGAACTGCA	0.567													17	19					2.35188e-11	2.78998e-11	1	0	T	88328847	T	T	88328847	3	4	298	1	0	0	0	0	1	0	0	0	14810	1087	38	3	1206	3	SLITRK5	13	88328847	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	34907084	88328847	26841031	67	55171											
JUB	84962	broad.mit.edu	37	chr14	23451177	23451177	+	Frame_Shift_Del	DEL	G	-	-																															ggggcaacgactgaggtagaGgcaaggcccgggtgggcggc																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr14:23451177delG	uc001whz.2	-	1	675	c.299delC	c.(298-300)CCTfs	p.P100fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	100	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CTGAGGTAGAGGCAAGGCCCG	0.701													---	---	---								-	23451177	-	-	23451177	7	5	298	1	0	1	0	1	0	0	0	0	8007	1000	35	0	1349	0	JUB	14	23451177	Frame_Shift_Del	DEL	G	TCGA-HD-7753-01A-11D-2078-08		23451177	83898363	68	55172											
COQ6	51004	broad.mit.edu	37	chr14	74428218	74428218	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtcaacatgggctttggggaTatctccagcttggcccatca	8	11	11	11	0	3	0	2	0	1	0	4	1	3	1	2	4	2	2	2	4	2	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr14:74428218T>A	uc001xph.2	+	10	1235	c.1155T>A	c.(1153-1155)GAT>GAA	p.D385E	ENTPD5_uc001xpi.2_Intron|COQ6_uc001xpe.2_Missense_Mutation_p.D310E|COQ6_uc001xpf.2_Missense_Mutation_p.D310E|COQ6_uc010tuk.1_Missense_Mutation_p.D360E|COQ6_uc001xpg.2_Missense_Mutation_p.D385E	NM_182476	NP_872282	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 homolog isoform a	385					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.00337)		GCTTTGGGGATATCTCCAGCT	0.512													10	27					0	0	0	0	A	74428218	A	A	74428218	3	1	298	1	0	0	0	0	1	0	0	0	3764	1403	49	5	1193	5	COQ6	14	74428218	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	50977041	74428218	32921322	69	55173											
HERC2	8924	broad.mit.edu	37	chr15	28446658	28446659	+	Frame_Shift_Ins	INS	-	T	T																															ttactcaagaaatcagctcgINSttttttgtacgtctggctct																								rs146159039	byFrequency	TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:28446658_28446659insT	uc001zbj.2	-	48	7765_7766	c.7659_7660insA	c.(7657-7662)AAACGAfs	p.K2553fs	HERC2_uc001zbk.1_Frame_Shift_Ins_p.K88fs	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2553_2554					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AAATCAGCTCGTTTTTTGTACG	0.366													---	---	---								T	28446659	T	T	28446658	7	5	298	1	0	1	1	0	0	0	0	0	7097	1153	40	0	7028	0	HERC2	15	28446658	Frame_Shift_Ins	INS	-	TCGA-HD-7753-01A-11D-2078-08		28446658	74084734	70	55174											
TRPM7	54822	broad.mit.edu	37	chr15	50935734	50935734	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgacttcaggtttggtgtcaTatgatagcctcacatactag	10	14	9	8	0	3	2	3	2	0	0	3	2	3	2	1	2	2	1	1	2	4	6			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:50935734T>C	uc001zyt.3	-	5	602	c.338A>G	c.(337-339)TAT>TGT	p.Y113C	TRPM7_uc010bew.1_Missense_Mutation_p.Y113C	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	113	Cytoplasmic (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TTTGGTGTCATATGATAGCCT	0.338													16	40					0	0	0	0	C	50935734	C	C	50935734	3	2	298	1	0	0	0	0	1	0	0	0	16658	1406	49	5	5399	5	TRPM7	15	50935734	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	22489076	50935734	51595658	71	55175											
IQCH	64799	broad.mit.edu	37	chr15	67786666	67786666	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcttcatcatccatcaagaaAtatcagcacctaatatgcaa	16	11	3	11	0	5	1	4	0	1	1	6	1	6	1	2	0	2	2	2	0	6	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:67786666A>G	uc002aqo.1	+	20	2979	c.2932A>G	c.(2932-2934)ATA>GTA	p.I978V	IQCH_uc002aqq.1_Missense_Mutation_p.I635V|IQCH_uc002aqp.1_Missense_Mutation_p.N618S|uc002aqr.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	978										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		CCATCAAGAAATATCAGCACC	0.398													5	21					0	0	0	0	G	67786666	G	G	67786666	3	3	298	1	0	0	0	0	1	0	0	0	7850	101	4	5	3138	5	IQCH	15	67786666	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	16850932	67786666	34744726	72	55176											
MESDC2	23184	broad.mit.edu	37	chr15	81282115	81282115	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggaccacggccttgcgcgcCcacctggaagccgccatttt	7	7	11	16	4	0	0	0	0	0	0	0	2	0	2	6	3	2	0	6	3	1	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:81282115C>T	uc002bfy.1	-	1	91	c.18G>A	c.(16-18)TGG>TGA	p.W6*	MESDC2_uc002bfx.2_RNA|MESDC2_uc010uno.1_RNA	NM_015154	NP_055969	Q14696	MESD_HUMAN	mesoderm development candidate 2	6	Chaperone domain (By similarity).				mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum					0						CCTTGCGCGCCCACCTGGAAG	0.642													8	11					0	0	0	0	T	81282115	T	T	81282115	4	4	298	1	0	0	0	0	0	1	0	0	9534	624	22	4	698	4	MESDC2	15	81282115	Nonsense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	13495449	81282115	21249277	73	55177											
SLCO3A1	28232	broad.mit.edu	37	chr15	92671678	92671678	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagtgtgtggggcagatggcAtcacctacctgtctgcctgc	6	10	13	12	0	2	1	1	0	1	1	2	1	2	1	3	3	3	2	3	3	1	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:92671678A>T	uc002bqx.2	+	7	1672	c.1471A>T	c.(1471-1473)ATC>TTC	p.I491F	SLCO3A1_uc002bqy.2_Missense_Mutation_p.I491F|SLCO3A1_uc010boc.1_RNA|SLCO3A1_uc002bqz.1_Missense_Mutation_p.I433F	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	491	Extracellular (Potential).|Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			GGCAGATGGCATCACCTACCT	0.463													19	45					0	0	0	0	T	92671678	T	T	92671678	3	4	298	1	0	0	0	0	1	0	0	0	14792	217	8	5	1497	5	SLCO3A1	15	92671678	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	11389563	92671678	9859714	74	55178											
ST8SIA2	8128	broad.mit.edu	37	chr15	93007600	93007600	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aaactgactgtcggccagtgCgatggggccacgtagggtgg	8	7	17	9	3	0	1	0	1	0	0	1	2	0	1	2	5	2	1	2	5	2	1	rs113311093		TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr15:93007600C>T	uc002bra.2	+	6	1268	c.1113C>T	c.(1111-1113)TGC>TGT	p.C371C	ST8SIA2_uc002brb.2_Silent_p.C350C	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	371	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			TCGGCCAGTGCGATGGGGCCA	0.597													27	57					0	0	0	0	T	93007600	T	T	93007600	2	4	298	1	0	0	0	0	0	0	0	1	15298	776	27	1		1	ST8SIA2	15	93007600	Silent	SNP	C	TCGA-HD-7753-01A-11D-2078-08	335922	93007600	9523792	75	55179											
VASN	114990	broad.mit.edu	37	chr16	4432380	4432381	+	Frame_Shift_Ins	INS	-	A	A																															cgtctcacctatcgcaacctINSatcgggccctgataagcggc																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr16:4432380_4432381insA	uc002cwj.1	+	2	1657_1658	c.1502_1503insA	c.(1501-1503)CTAfs	p.L501fs	CORO7_uc002cwe.2_Intron|CORO7_uc002cwf.2_Intron|CORO7_uc002cwg.3_Intron|CORO7_uc002cwh.3_Intron|CORO7_uc010uxh.1_Intron|CORO7_uc010uxi.1_Intron|CORO7_uc002cwi.1_Intron|CORO7_uc010uxj.1_Intron|CORO7_uc010btp.1_Intron	NM_138440	NP_612449	Q6EMK4	VASN_HUMAN	slit-like 2 precursor	501	Fibronectin type-III.|Extracellular (Potential).					extracellular region|integral to membrane					0						TATCGCAACCTATCGGGCCCTG	0.668													---	---	---								A	4432381	A	A	4432380	7	5	298	1	0	1	1	0	0	0	0	0	17195	1522	53	0	1504	0	VASN	16	4432380	Frame_Shift_Ins	INS	-	TCGA-HD-7753-01A-11D-2078-08		4432380	85922373	76	55180											
DNAH3	55567	broad.mit.edu	37	chr16	21078616	21078616	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ctggatacctggggaagaatAgtctcttcttctccaagtaa	11	12	9	9	0	3	1	0	0	3	1	5	3	3	3	2	3	1	1	2	3	6	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr16:21078616A>G	uc010vbe.1	-	24	3506	c.3506T>C	c.(3505-3507)CTA>CCA	p.L1169P		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1169	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GGGGAAGAATAGTCTCTTCTT	0.438													21	13					0	0	0	0	G	21078616	G	G	21078616	3	3	298	1	0	0	0	0	1	0	0	0	4625	420	15	5	8999	5	DNAH3	16	21078616	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	16646236	21078616	69276137	77	55181											
CHD9	80205	broad.mit.edu	37	chr16	53358379	53358379	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agtcagaaggaaaaacagaaAggacagagagccaaagttca	21	3	11	6	0	2	3	2	0	0	3	2	6	2	5	1	2	2	1	1	2	5	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr16:53358379A>G	uc002ehb.2	+	38	8430	c.8266A>G	c.(8266-8268)AGG>GGG	p.R2756G	CHD9_uc002egy.2_Missense_Mutation_p.R2740G|CHD9_uc002ehc.2_Missense_Mutation_p.R2741G|CHD9_uc002ehf.2_Missense_Mutation_p.R1854G|CHD9_uc010cbw.2_Missense_Mutation_p.R822G	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2756					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				AAAAACAGAAAGGACAGAGAG	0.463													19	24					0	0	0	0	G	53358379	G	G	53358379	3	3	298	1	0	0	0	0	1	0	0	0	3347	63	3	5	8368	5	CHD9	16	53358379	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	32279763	53358379	36996374	78	55182											
ZZEF1	23140	broad.mit.edu	37	chr17	3921231	3921231	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctgagccagggaccgtaTcctttcatctgtggtgagct	6	11	12	12	2	2	2	1	2	1	0	3	3	3	3	4	2	2	3	4	2	1	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:3921231T>A	uc002fxe.2	-	47	7604	c.7540A>T	c.(7540-7542)ATA>TTA	p.I2514L	ZZEF1_uc002fxg.1_5'Flank	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2514							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGGGACCGTATCCTTTCATCT	0.507													9	38					0	0	0	0	A	3921231	A	A	3921231	3	1	298	1	0	0	0	0	1	0	0	0	18322	1435	50	5	1381	5	ZZEF1	17	3921231	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08		3921231	77273979	79	55183											
USP6	9098	broad.mit.edu	37	chr17	5042664	5042664	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cccaccagcccagttccagcGgcccatttgctcagcttccc	6	8	7	20	1	1	0	1	0	0	0	3	0	3	0	6	1	4	3	6	1	0	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:5042664G>A	uc002gau.1	+	22	3423	c.1193G>A	c.(1192-1194)CGG>CAG	p.R398Q	USP6_uc002gav.1_Missense_Mutation_p.R398Q|USP6_uc010ckz.1_Missense_Mutation_p.R81Q|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	398					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						CAGTTCCAGCGGCCCATTTGC	0.657			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								7	24					0	0	0	0	A	5042664	A	A	5042664	3	1	298	1	0	0	0	0	1	0	0	0	17154	1116	39	1	1243	1	USP6	17	5042664	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	1121433	5042664	76152546	80	55184											
TP53	7157	broad.mit.edu	37	chr17	7577115	7577116	+	In_Frame_Ins	INS	-	AAC	AAC																															tctctcccaggacaggcacaINSaacacgcacctcaaagctgt																										TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:7577115_7577116insAAC	uc002gim.2	-	8	1016_1017	c.822_823insGTT	c.(820-825)insGTT	p.274_275insV	TP53_uc002gig.1_Intron|TP53_uc002gih.2_In_Frame_Ins_p.274_275insV|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Ins_p.142_143insV|TP53_uc010cng.1_In_Frame_Ins_p.142_143insV|TP53_uc002gii.1_In_Frame_Ins_p.142_143insV|TP53_uc010cnh.1_In_Frame_Ins_p.274_275insV|TP53_uc010cni.1_In_Frame_Ins_p.274_275insV|TP53_uc002gij.2_In_Frame_Ins_p.274_275insV	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	274_275	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V274F(17)|p.V274A(13)|p.V274L(9)|p.C275G(7)|p.V274D(7)|p.0?(7)|p.C275R(6)|p.V274G(6)|p.V274I(4)|p.V274V(3)|p.C275fs*31(2)|p.?(2)|p.V274fs*71(1)|p.R273_C275delRVC(1)|p.V274_P278del(1)|p.C275fs*70(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGACAGGCACAAACACGCACCT	0.55		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								AAC	7577116	AAC	AAC	7577115	7	5	298	1	0	1	1	0	0	0	0	0	16448	130	5	0	463	0	TP53	17	7577115	In_Frame_Ins	INS	-	TCGA-HD-7753-01A-11D-2078-08	2534451	7577115	73618095	81	55185											
ZNF286A	57335	broad.mit.edu	37	chr17	15620349	15620349	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	attcacactggagagaaaccCtatgagtgtaatgaatgtgg	14	10	11	6	0	1	3	1	2	0	1	1	5	1	4	1	2	1	1	1	2	4	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:15620349C>T	uc010cot.2	+	6	1707	c.1311C>T	c.(1309-1311)CCC>CCT	p.P437P	ZNF286A_uc002goz.3_Silent_p.P325P|ZNF286A_uc010vwa.1_Silent_p.P437P|ZNF286A_uc002gpa.2_Silent_p.P437P	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		GAGAGAAACCCTATGAGTGTA	0.388													14	23					0	0	0	0	T	15620349	T	T	15620349	2	4	298	1	0	0	0	0	0	0	0	1	17890	668	24	4		4	ZNF286A	17	15620349	Silent	SNP	C	TCGA-HD-7753-01A-11D-2078-08	8043234	15620349	65574861	82	55186											
GPR179	440435	broad.mit.edu	37	chr17	36485312	36485312	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcacttgcctcccagggacaCggctctgccttggtgatgtc	5	11	11	14	1	2	1	1	1	1	0	4	2	3	2	3	3	2	1	3	3	0	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:36485312C>A	uc002hpz.2	-	11	4161	c.4140G>T	c.(4138-4140)CCG>CCT	p.P1380P		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1380	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCCAGGGACACGGCTCTGCCT	0.597													42	73					2.35958e-20	3.00537e-20	1	0	A	36485312	A	A	36485312	2	1	298	1	0	0	0	0	0	0	0	1	6712	523	19	3		3	GPR179	17	36485312	Silent	SNP	C	TCGA-HD-7753-01A-11D-2078-08	20864963	36485312	44709898	83	55187											
MED1	5469	broad.mit.edu	37	chr17	37564173	37564173	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtggaaccactgatgagtGgagagccatagtttttagaa	13	10	13	5	0	0	4	0	2	0	2	0	7	0	5	2	2	2	1	2	2	4	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:37564173G>A	uc002hrv.3	-	17	4513	c.4301C>T	c.(4300-4302)CCA>CTA	p.P1434L	MED1_uc010wee.1_Missense_Mutation_p.P1262L|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1434	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		ACTGATGAGTGGAGAGCCATA	0.488										HNSCC(31;0.082)			19	41					0	0	0	0	A	37564173	A	A	37564173	3	1	298	1	0	0	0	0	1	0	0	0	9478	1348	47	4	448	4	MED1	17	37564173	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	1078861	37564173	43631037	84	55188											
CCR7	1236	broad.mit.edu	37	chr17	38711204	38711204	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caggccaggctgtaggtgacGtcgtaggcgatgttgagttg	7	10	17	7	3	0	2	0	2	0	0	1	3	0	2	1	4	0	5	1	4	2	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:38711204G>A	uc002huw.2	-	3	990	c.927C>T	c.(925-927)GAC>GAT	p.D309D		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	309	Extracellular (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				TGTAGGTGACGTCGTAGGCGA	0.567													9	38					0	0	0	0	A	38711204	A	A	38711204	2	1	298	1	0	0	0	0	0	0	0	1	2961	1136	40	1		1	CCR7	17	38711204	Silent	SNP	G	TCGA-HD-7753-01A-11D-2078-08	1147031	38711204	42484006	85	55189											
TANC2	26115	broad.mit.edu	37	chr17	61432352	61432352	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gaccctcagtcaagggtcctAtctatatctgaaacttacat	12	12	6	11	0	4	1	2	1	2	0	5	2	5	1	2	1	2	0	2	1	6	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr17:61432352A>G	uc002jal.3	+	12	1984	c.1961A>G	c.(1960-1962)TAT>TGT	p.Y654C	TANC2_uc010wpe.1_Missense_Mutation_p.Y564C|TANC2_uc002jam.1_Missense_Mutation_p.Y21C	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	654							binding			ovary(2)	2						CAAGGGTCCTATCTATATCTG	0.388													38	84					0	0	0	0	G	61432352	G	G	61432352	3	3	298	1	0	0	0	0	1	0	0	0	15611	449	16	5	2007	5	TANC2	17	61432352	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	22721148	61432352	19762858	86	55190											
ZNF521	25925	broad.mit.edu	37	chr18	22807417	22807417	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctcggctgcgcttgtgtttGaacagcctactgcagtaggt	6	13	12	10	2	1	1	0	1	1	0	2	1	1	1	1	2	5	5	1	2	3	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr18:22807417G>C	uc002kvk.2	-	4	712	c.465C>G	c.(463-465)TTC>TTG	p.F155L	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.F155L|ZNF521_uc002kvl.2_5'UTR	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	155	C2H2-type 3.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GCTTGTGTTTGAACAGCCTAC	0.498			T	PAX5	ALL								14	64					0	0	0	0	C	22807417	C	C	22807417	3	2	298	1	0	0	0	0	1	0	0	0	18032	1281	45	2	3490	2	ZNF521	18	22807417	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08		22807417	55269831	87	55191											
RIT2	6014	broad.mit.edu	37	chr18	40695399	40695399	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	taccgcttttaccaactcccCctgctcccagcattaccacc	8	10	3	20	1	0	0	0	0	0	0	2	0	2	0	7	0	6	3	7	0	4	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr18:40695399C>T	uc002lav.2	-	1	259	c.86G>A	c.(85-87)GGG>GAG	p.G29E	RIT2_uc010dnf.2_Missense_Mutation_p.G29E	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	29	GTP (By similarity).				nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						ACCAACTCCCCCTGCTCCCAG	0.512													20	189					0	0	0	0	T	40695399	T	T	40695399	3	4	298	1	0	0	0	0	1	0	0	0	13452	623	22	4	587	4	RIT2	18	40695399	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	17887982	40695399	37381849	88	55192											
SYT4	6860	broad.mit.edu	37	chr18	40850388	40850388	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tccagtgctctccaccagttCcttctgctgctgcacccaag	6	11	7	17	0	2	0	0	0	2	0	5	0	4	0	5	0	4	5	5	0	1	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr18:40850388C>G	uc002law.2	-	4	1565	c.1196G>C	c.(1195-1197)GGA>GCA	p.G399A	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Missense_Mutation_p.G381A|SYT4_uc010dnh.2_RNA	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	399	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TCCACCAGTTCCTTCTGCTGC	0.493													34	208					0	0	0	0	G	40850388	G	G	40850388	3	3	298	1	0	0	0	0	1	0	0	0	15542	855	30	2	85	2	SYT4	18	40850388	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	154989	40850388	37226860	89	55193											
DCC	1630	broad.mit.edu	37	chr18	50432611	50432611	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgcagatcagccgactccaaCcgggggacattggaatttac	11	8	11	11	2	1	1	1	0	0	1	2	4	2	3	3	3	4	1	3	3	3	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr18:50432611C>A	uc002lfe.1	+	3	1197	c.610C>A	c.(610-612)CCG>ACG	p.P204T	DCC_uc010xdr.1_Missense_Mutation_p.P52T	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	204	Extracellular (Potential).|Ig-like C2-type 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCGACTCCAACCGGGGGACAT	0.502													7	24					0.000442599	0.000465692	1	0	A	50432611	A	A	50432611	3	1	298	1	0	0	0	0	1	0	0	0	4299	507	18	4	620	4	DCC	18	50432611	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	9582223	50432611	27644637	90	55194											
ZADH2	284273	broad.mit.edu	37	chr18	72914167	72914167	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	cttggccaactgtgtatctgGcactagcagagaggcctagg	9	9	13	10	0	1	1	0	0	1	1	1	2	1	1	2	4	2	3	2	4	4	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr18:72914167G>T	uc002llx.2	-	2	606	c.338C>A	c.(337-339)GCC>GAC	p.A113D	ZADH2_uc010dqv.2_5'UTR	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	113						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		TGTGTATCTGGCACTAGCAGA	0.542													15	48					3.27435e-08	3.70277e-08	1	0	T	72914167	T	T	72914167	3	4	298	1	0	0	0	0	1	0	0	0	17579	1203	42	4	799	4	ZADH2	18	72914167	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	22481556	72914167	5163081	91	55195											
ZNF99	7652	broad.mit.edu	37	chr19	22941472	22941472	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtatgaattaccttatgtacAgtaagttttgaggaccactt	12	15	8	6	0	0	2	0	2	0	0	0	3	0	3	2	1	2	4	2	1	6	8			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:22941472A>G	uc010xrh.1	-	5	966	c.966T>C	c.(964-966)ACT>ACC	p.T322T		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CCTTATGTACAGTAAGTTTTG	0.363													15	25					0	0	0	0	G	22941472	G	G	22941472	2	3	298	1	0	0	0	0	0	0	0	1	18271	175	7	5		5	ZNF99	19	22941472	Silent	SNP	A	TCGA-HD-7753-01A-11D-2078-08		22941472	36187511	92	55196											
ZNF383	163087	broad.mit.edu	37	chr19	37733572	37733572	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tagtcaagaaatattcactcCtgaatacatgcccacattta	15	12	4	10	0	2	2	2	1	0	1	3	2	3	2	2	0	2	0	2	0	7	6			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:37733572C>T	uc002oft.1	+	8	1014	c.434C>T	c.(433-435)CCT>CTT	p.P145L	ZNF383_uc002ofs.1_Missense_Mutation_p.P80L|ZNF383_uc002ofu.1_Missense_Mutation_p.P145L	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATATTCACTCCTGAATACATG	0.368													30	54					0	0	0	0	T	37733572	T	T	37733572	3	4	298	1	0	0	0	0	1	0	0	0	17941	681	24	4	448	4	ZNF383	19	37733572	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	14792100	37733572	21395411	93	55197											
RASGRP4	115727	broad.mit.edu	37	chr19	38903847	38903847	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccttacctccaccagctgctCcacatgccgacccagtgtga	8	8	7	18	1	0	1	0	1	0	0	2	2	2	1	7	0	4	2	7	0	1	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:38903847C>T	uc002oir.2	-	11	1616	c.1402G>A	c.(1402-1404)GAG>AAG	p.E468K	RASGRP4_uc010efz.1_RNA|RASGRP4_uc010ega.1_RNA|RASGRP4_uc010xua.1_Missense_Mutation_p.E399K|RASGRP4_uc010xub.1_Missense_Mutation_p.E434K|RASGRP4_uc010xuc.1_Missense_Mutation_p.E376K|RASGRP4_uc010xud.1_Missense_Mutation_p.E371K|RASGRP4_uc010xue.1_Missense_Mutation_p.E279K|RASGRP4_uc010egb.2_Missense_Mutation_p.E454K	NM_170604	NP_733749	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4 isoform a	468	EF-hand.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			pancreas(1)|lung(1)|skin(1)	3	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			ACCAGCTGCTCCACATGCCGA	0.667													7	13					0	0	0	0	T	38903847	T	T	38903847	3	4	298	1	0	0	0	0	1	0	0	0	13142	864	30	2	647	2	RASGRP4	19	38903847	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	1170275	38903847	20225136	94	55198											
ZNF404	342908	broad.mit.edu	37	chr19	44377455	44377455	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgcgaacaaaggccttttcaCattgttcacatttatatggt	11	15	7	8	1	2	0	2	0	0	0	2	1	2	0	1	2	2	1	1	2	4	7			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:44377455C>T	uc002oxs.3	-	2	911	c.902G>A	c.(901-903)TGT>TAT	p.C301Y		NM_001033719	NP_001028891	Q494X3	ZN404_HUMAN	zinc finger protein 404	304	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				GGCCTTTTCACATTGTTCACA	0.368													5	21					0	0	0	0	T	44377455	T	T	44377455	3	4	298	1	0	0	0	0	1	0	0	0	17953	478	17	4	751	4	ZNF404	19	44377455	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	5473608	44377455	14751528	95	55199											
ZC3H4	23211	broad.mit.edu	37	chr19	47584838	47584838	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catgcagtcgtcaccattgaTgcagttcccagtggtgtggt	7	12	12	10	1	1	1	1	1	0	0	3	1	2	1	2	2	2	3	2	2	0	2			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:47584838T>C	uc002pga.3	-	11	1410	c.1372A>G	c.(1372-1374)ATC>GTC	p.I458V	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	458	C3H1-type 3.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TCACCATTGATGCAGTTCCCA	0.547													16	26					0	0	0	0	C	47584838	C	C	47584838	3	2	298	1	0	0	0	0	1	0	0	0	17637	1464	51	5	2559	5	ZC3H4	19	47584838	Missense_Mutation	SNP	T	TCGA-HD-7753-01A-11D-2078-08	3207383	47584838	11544145	96	55200											
MED25	81857	broad.mit.edu	37	chr19	50334077	50334077	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	accacctgcttcccagcccaGtctggtctccactgtggccc	5	9	8	19	0	2	0	0	0	2	0	4	0	3	0	6	2	2	1	6	2	0	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:50334077G>T	uc002ppw.1	+	9	1087	c.1034G>T	c.(1033-1035)AGT>ATT	p.S345I	MED25_uc010ybe.1_Missense_Mutation_p.S132I|MED25_uc002ppx.1_Missense_Mutation_p.S126I	NM_030973	NP_112235	Q71SY5	MED25_HUMAN	mediator complex subunit 25	345	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)		TCCCAGCCCAGTCTGGTCTCC	0.726													21	28					7.41877e-09	8.46937e-09	1	0	T	50334077	T	T	50334077	3	4	298	1	0	0	0	0	1	0	0	0	9496	1029	36	4	1068	4	MED25	19	50334077	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	2749239	50334077	8794906	97	55201											
ZNF611	81856	broad.mit.edu	37	chr19	53209236	53209236	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atgaattctatgatgtgaaaGttgtgattgttgattaaaag	14	16	10	1	0	1	5	0	5	1	0	1	5	1	5	0	0	0	2	0	0	5	6			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr19:53209236G>A	uc002pzz.2	-	7	1389	c.1072C>T	c.(1072-1074)CTT>TTT	p.L358F	ZNF611_uc010eqc.2_Missense_Mutation_p.L288F|ZNF611_uc010ydo.1_Missense_Mutation_p.L288F|ZNF611_uc010ydr.1_Missense_Mutation_p.L289F|ZNF611_uc010ydp.1_Missense_Mutation_p.L358F|ZNF611_uc010ydq.1_Missense_Mutation_p.L358F|ZNF611_uc002qaa.3_Missense_Mutation_p.L288F	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	358	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TGATGTGAAAGTTGTGATTGT	0.343													8	48					0	0	0	0	A	53209236	A	A	53209236	3	1	298	1	0	0	0	0	1	0	0	0	18104	1029	36	4	1049	4	ZNF611	19	53209236	Missense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	2875159	53209236	5919747	98	55202											
SDC4	6385	broad.mit.edu	37	chr20	43977029	43977029	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacgggcgggggccatggcaCcgcggactggagaaggcgcg	7	2	21	11	6	0	1	0	0	0	1	0	4	0	2	2	7	0	1	2	7	1	0			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr20:43977029C>T	uc002xnu.2	-	1	36	c.-4G>A	c.(-6--2)CGGTG>CGATG		SDC4_uc010zws.1_Translation_Start_Site	NM_002999	NP_002990	P31431	SDC4_HUMAN	syndecan 4 precursor							extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity				0		Myeloproliferative disorder(115;0.0122)				GGCCATGGCACCGCGGACTGG	0.647													6	5					0	0	0	0	T	43977029	T	T	43977029	1	4	298	1	0	0	0	0	0	0	0	0	14019	522	18	4		4	SDC4	20	43977029	Translation_Start_Site	SNP	C	TCGA-HD-7753-01A-11D-2078-08		43977029	19048491	99	55203											
TTC3	7267	broad.mit.edu	37	chr21	38567994	38567994	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aggttcatcccgagttactcCctgagtcttcaggcgacgat	8	11	10	12	3	3	1	2	1	1	0	5	4	5	1	2	2	1	2	2	2	1	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr21:38567994C>T	uc002yvz.2	+	42	5341	c.5236C>T	c.(5236-5238)CCT>TCT	p.P1746S	TTC3_uc002ywa.2_Missense_Mutation_p.P1746S|TTC3_uc002ywb.2_Missense_Mutation_p.P1746S|TTC3_uc010gnf.2_Missense_Mutation_p.P1511S|TTC3_uc002ywc.2_Missense_Mutation_p.P1436S	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1746					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				CGAGTTACTCCCTGAGTCTTC	0.532													39	145					0	0	0	0	T	38567994	T	T	38567994	3	4	298	1	0	0	0	0	1	0	0	0	16765	623	22	4	5398	4	TTC3	21	38567994	Missense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08		38567994	9561901	100	55204											
UMODL1	89766	broad.mit.edu	37	chr21	43547902	43547902	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtctacctgcactgcaaactCcgcgtctgcatggaatcccc	8	9	8	16	2	2	0	0	0	2	0	4	1	4	1	4	1	5	3	4	1	3	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr21:43547902C>A	uc002zaf.1	+	20	3651	c.3651C>A	c.(3649-3651)CTC>CTA	p.L1217L	UMODL1_uc002zad.1_Silent_p.L1145L|UMODL1_uc002zae.1_Silent_p.L1273L|UMODL1_uc002zag.1_Silent_p.L1345L|UMODL1_uc002zal.1_Silent_p.L167L|UMODL1_uc010gpa.1_RNA	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	1217	Extracellular (Potential).|ZP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						ACTGCAAACTCCGCGTCTGCA	0.468													7	33					0.00198382	0.00205164	1	0	A	43547902	A	A	43547902	2	1	298	1	0	0	0	0	0	0	0	1	17048	842	30	2		2	UMODL1	21	43547902	Silent	SNP	C	TCGA-HD-7753-01A-11D-2078-08	4979908	43547902	4581993	101	55205											
POTEH	23784	broad.mit.edu	37	chr22	16267045	16267045	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtggcaccgttagtcaggttTtctgggaatcccatatgagt	8	13	12	8	1	2	1	1	1	1	0	3	2	3	2	2	3	0	3	2	3	3	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr22:16267045T>C	uc010gqp.2	-	9	1456	c.1404A>G	c.(1402-1404)GAA>GAG	p.E468E	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Silent_p.E187E|POTEH_uc002zlj.1_Silent_p.E303E	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	468										skin(1)	1						TAGTCAGGTTTTCTGGGAATC	0.403													42	197					0	0	0	0	C	16267045	C	C	16267045	2	2	298	1	0	0	0	0	0	0	0	1	12322	1838	64	5		5	POTEH	22	16267045	Silent	SNP	T	TCGA-HD-7753-01A-11D-2078-08		16267045	35037521	102	55206											
TOM1	10043	broad.mit.edu	37	chr22	35726367	35726367	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accgcacgtgccgagccatgCagcagcgggtcctggagctc	7	5	14	15	4	0	0	0	0	0	0	2	2	1	1	4	2	6	4	4	2	0	0			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chr22:35726367C>T	uc003ann.2	+	8	918	c.793C>T	c.(793-795)CAG>TAG	p.Q265*	TOM1_uc011ami.1_Nonsense_Mutation_p.Q232*|TOM1_uc011amj.1_Nonsense_Mutation_p.Q108*|TOM1_uc003ans.2_Nonsense_Mutation_p.Q108*|TOM1_uc011amk.1_Nonsense_Mutation_p.Q227*|TOM1_uc003anp.2_Nonsense_Mutation_p.Q265*|TOM1_uc011aml.1_Nonsense_Mutation_p.Q220*|TOM1_uc003ano.2_RNA|TOM1_uc003anq.2_Nonsense_Mutation_p.Q259*|TOM1_uc003anr.2_Nonsense_Mutation_p.Q108*	NM_005488	NP_005479	O60784	TOM1_HUMAN	target of myb1 isoform 1	265	GAT.				endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			ovary(1)	1						CCGAGCCATGCAGCAGCGGGT	0.517													32	67					0	0	0	0	T	35726367	T	T	35726367	4	4	298	1	0	0	0	0	0	1	0	0	16417	711	25	4	823	4	TOM1	22	35726367	Nonsense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	19459322	35726367	15578199	103	55207											
MID1	4281	broad.mit.edu	37	chrX	10535569	10535569	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acaaatagggcaggtcagttCtgactccagtgtttccatct	10	12	9	10	0	3	1	1	1	2	0	5	1	5	1	2	2	0	3	2	2	2	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chrX:10535569C>A	uc004cte.3	-	2	210	c.19G>T	c.(19-21)GAA>TAA	p.E7*	MID1_uc004ctd.3_5'Flank|MID1_uc004ctg.3_Nonsense_Mutation_p.E7*|MID1_uc004cth.3_Nonsense_Mutation_p.E7*|MID1_uc004ctk.3_Nonsense_Mutation_p.E7*|MID1_uc004cti.3_Nonsense_Mutation_p.E7*|MID1_uc004ctj.3_Nonsense_Mutation_p.E7*|MID1_uc011mie.1_RNA|MID1_uc004ctm.1_Nonsense_Mutation_p.E7*|MID1_uc004ctn.1_Nonsense_Mutation_p.E7*|MID1_uc004cto.1_Nonsense_Mutation_p.E7*|MID1_uc010ndw.1_5'Flank|MID1_uc004cts.1_5'Flank|MID1_uc004ctt.2_Nonsense_Mutation_p.E7*|MID1_uc004ctu.2_Nonsense_Mutation_p.E7*|MID1_uc004ctv.2_Nonsense_Mutation_p.E7*|MID1_uc004ctw.2_Nonsense_Mutation_p.E7*|MID1_uc010ndy.1_Nonsense_Mutation_p.E7*|uc010ndz.1_5'Flank|MID1_uc004cty.2_Nonsense_Mutation_p.E7*|MID1_uc004ctz.1_5'Flank|MID1_uc004cua.1_RNA|MID1_uc004cub.1_Nonsense_Mutation_p.E7*|MID1_uc010nea.1_5'Flank|MID1_uc004cuc.1_Nonsense_Mutation_p.E7*|MID1_uc004cud.1_Nonsense_Mutation_p.E7*|MID1_uc004cue.1_Nonsense_Mutation_p.E7*|MID1_uc004cuf.1_Nonsense_Mutation_p.E7*|MID1_uc004cug.1_Nonsense_Mutation_p.E7*	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	7					microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						CAGGTCAGTTCTGACTCCAGT	0.493													28	20					4.87955e-14	5.90426e-14	1	0	A	10535569	A	A	10535569	4	1	298	1	0	0	0	0	0	1	0	0	9629	922	32	2	2020	2	MID1	23	10535569	Nonsense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08		10535569	144734991	104	55208											
GPR64	10149	broad.mit.edu	37	chrX	19022940	19022940	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgaaagcccacaaccaatatAtgtaatgaacgtcagagcca	17	7	7	10	1	1	3	1	2	0	1	1	3	1	3	3	0	4	1	3	0	7	3			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chrX:19022940A>G	uc004cyx.2	-	23	2061	c.1897T>C	c.(1897-1899)TAT>CAT	p.Y633H	GPR64_uc004cyy.2_Missense_Mutation_p.Y630H|GPR64_uc004cyz.2_Missense_Mutation_p.Y619H|GPR64_uc004czb.2_Missense_Mutation_p.Y633H|GPR64_uc004czc.2_Missense_Mutation_p.Y617H|GPR64_uc004czd.2_Missense_Mutation_p.Y609H|GPR64_uc004cze.2_Missense_Mutation_p.Y603H|GPR64_uc004czf.2_Missense_Mutation_p.Y595H|GPR64_uc004cza.2_Missense_Mutation_p.Y611H|GPR64_uc004cyw.2_Missense_Mutation_p.Y617H|GPR64_uc010nfj.2_Missense_Mutation_p.Y514H	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	633	Helical; Name=1; (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					CAACCAATATATGTAATGAAC	0.353													27	56					0	0	0	0	G	19022940	G	G	19022940	3	3	298	1	0	0	0	0	1	0	0	0	6743	449	16	5	1184	5	GPR64	23	19022940	Missense_Mutation	SNP	A	TCGA-HD-7753-01A-11D-2078-08	8487371	19022940	136247620	105	55209											
KDM6A	7403	broad.mit.edu	37	chrX	44922694	44922694	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	caacaggagttgcacaggtaCgatctactggaattcctaat	13	10	9	9	1	1	0	0	0	1	0	2	3	2	2	1	3	4	3	1	3	5	5			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chrX:44922694C>T	uc004dge.3	+	16	1930	c.1555C>T	c.(1555-1557)CGA>TGA	p.R519*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.R485*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.R571*|KDM6A_uc011mla.1_Nonsense_Mutation_p.R474*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.R526*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.R223*|KDM6A_uc011mld.1_Nonsense_Mutation_p.R158*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	519					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TGCACAGGTACGATCTACTGG	0.463			D|N|F|S		renal|oesophageal SCC|MM								18	37					0	0	0	0	T	44922694	T	T	44922694	4	4	298	1	0	0	0	0	0	1	0	0	8176	528	19	1	1617	1	KDM6A	23	44922694	Nonsense_Mutation	SNP	C	TCGA-HD-7753-01A-11D-2078-08	25899754	44922694	110347866	106	55210											
ZNF711	7552	broad.mit.edu	37	chrX	84526033	84526033	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ggactgttaaacaggcatttGttggccgttcacagcaagaa	12	10	11	8	1	1	1	1	0	0	1	1	2	1	2	1	3	2	5	1	3	4	4			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chrX:84526033G>A	uc004eeo.2	+	9	1832	c.1485G>A	c.(1483-1485)TTG>TTA	p.L495L	ZNF711_uc004eep.2_Silent_p.L495L|ZNF711_uc004eeq.2_Silent_p.L541L|ZNF711_uc011mqy.1_Silent_p.L94L	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	495	C2H2-type 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						ACAGGCATTTGTTGGCCGTTC	0.408													3	29					0	0	0	0	A	84526033	A	A	84526033	2	1	298	1	0	0	0	0	0	0	0	1	18183	1368	48	4		4	ZNF711	23	84526033	Silent	SNP	G	TCGA-HD-7753-01A-11D-2078-08	39603339	84526033	70744527	107	55211											
RGAG1	57529	broad.mit.edu	37	chrX	109696372	109696372	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aagtgaaggctcccatctctGgagcaatgtccatgccacta	11	9	9	12	0	1	1	0	1	1	0	4	2	3	2	3	2	2	2	3	2	4	1			TCGA-HD-7753-01A-11D-2078-08	TCGA-HD-7753-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	7dc33525-6f57-4b12-9b72-c9c845296ae3	0ca58135-303a-4e85-896e-7f7c75481e42	g.chrX:109696372G>T	uc004eor.1	+	3	2773	c.2527G>T	c.(2527-2529)GGA>TGA	p.G843*	RGAG1_uc011msr.1_Nonsense_Mutation_p.G843*	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	843										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TCCCATCTCTGGAGCAATGTC	0.517													61	32					1.49723e-40	1.92729e-40	1	0	T	109696372	T	T	109696372	4	4	298	1	0	0	0	0	0	1	0	0	13339	1349	47	4	2529	4	RGAG1	23	109696372	Nonsense_Mutation	SNP	G	TCGA-HD-7753-01A-11D-2078-08	25170339	109696372	45574188	108	55212											
GJB3	2707	broad.mit.edu	37	chr1	35250490	35250490	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgtggtggctgcagagcgcGtgtggggggatgagcagaag	8	6	21	6	3	0	3	0	1	0	2	0	4	0	4	0	5	3	3	0	5	1	0			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr1:35250490G>A	uc001bxx.2	+	2	742	c.127G>A	c.(127-129)GTG>ATG	p.V43M	GJB3_uc001bxy.2_Missense_Mutation_p.V43M|GJB3_uc001bxz.3_Missense_Mutation_p.V43M|uc010ohs.1_RNA	NM_024009	NP_076872	O75712	CXB3_HUMAN	connexin 31	43	Extracellular (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				TGCAGAGCGCGTGTGGGGGGA	0.592													5	18					0	0	0	0	A	35250490	A	A	35250490	3	1	299	1	0	0	0	0	1	0	0	0	6446	1145	40	1	129	1	GJB3	1	35250490	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08		35250490	214000131	1	55213											
SLC5A9	200010	broad.mit.edu	37	chr1	48701511	48701511	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgtgtggcagcgcttcCgcaggaagtcaacagagcag	10	8	14	9	2	1	2	1	1	0	1	2	3	2	3	1	2	3	4	1	2	2	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr1:48701511C>T	uc001cro.2	+	10	1304	c.1252C>T	c.(1252-1254)CGC>TGC	p.R418C	SLC5A9_uc010oms.1_RNA|SLC5A9_uc001crn.2_Missense_Mutation_p.R443C|SLC5A9_uc010omt.1_Missense_Mutation_p.R432C|SLC5A9_uc001crp.2_Missense_Mutation_p.R85C|SLC5A9_uc010omu.1_Missense_Mutation_p.R85C	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	418	Cytoplasmic (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						GCAGCGCTTCCGCAGGAAGTC	0.617													15	23					0	0	0	0	T	48701511	T	T	48701511	3	4	299	1	0	0	0	0	1	0	0	0	14736	652	23	1	1369	1	SLC5A9	1	48701511	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	13451021	48701511	200549110	2	55214											
PDE4B	5142	broad.mit.edu	37	chr1	66838038	66838038	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccatccattgtgggagacaTgggcagatttggtacagcct	9	11	12	9	0	0	2	0	0	0	2	2	3	2	2	3	3	2	2	3	3	1	3			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr1:66838038T>C	uc001dcn.2	+	17	2079	c.1888T>C	c.(1888-1890)TGG>CGG	p.W630R	PDE4B_uc009war.2_Missense_Mutation_p.W538R|PDE4B_uc001dco.2_Missense_Mutation_p.W630R|PDE4B_uc001dcp.2_Missense_Mutation_p.W615R|PDE4B_uc001dcq.2_Missense_Mutation_p.W458R|PDE4B_uc009was.2_Missense_Mutation_p.W397R	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	630					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	GTGGGAGACATGGGCAGATTT	0.433													30	45					0	0	0	0	C	66838038	C	C	66838038	3	2	299	1	0	0	0	0	1	0	0	0	11694	1464	51	5	2308	5	PDE4B	1	66838038	Missense_Mutation	SNP	T	TCGA-HD-7754-01A-11D-2078-08	18136527	66838038	182412583	3	55215											
WDR63	126820	broad.mit.edu	37	chr1	85564339	85564339	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actggttgtctgacacatttGaggtgagacttgatggcctt	8	14	12	7	0	1	4	0	4	1	1	1	5	1	4	1	3	0	1	1	3	0	4			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr1:85564339G>A	uc001dkt.2	+	13	1668	c.1477G>A	c.(1477-1479)GAG>AAG	p.E493K	WDR63_uc009wcl.2_Missense_Mutation_p.E454K	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	493	WD 2.									upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TGACACATTTGAGGTGAGACT	0.328													32	46					0	0	0	0	A	85564339	A	A	85564339	3	1	299	1	0	0	0	0	1	0	0	0	17382	1291	45	2	1523	2	WDR63	1	85564339	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	18726301	85564339	163686282	4	55216											
AGL	178	broad.mit.edu	37	chr1	100347238	100347238	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaggaagtgcctcaaatgTgcatccctggtaatgcaatc	12	9	10	10	0	1	0	1	0	0	0	3	1	2	1	2	2	3	4	2	2	5	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr1:100347238T>C	uc001dsi.1	+	17	2699	c.2299T>C	c.(2299-2301)TGC>CGC	p.C767R	AGL_uc001dsj.1_Missense_Mutation_p.C767R|AGL_uc001dsk.1_Missense_Mutation_p.C767R|AGL_uc001dsl.1_Missense_Mutation_p.C767R|AGL_uc001dsm.1_Missense_Mutation_p.C751R|AGL_uc001dsn.1_Missense_Mutation_p.C750R	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	767	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GCCTCAAATGTGCATCCCTGG	0.284													25	53					0	0	0	0	C	100347238	C	C	100347238	3	2	299	1	0	0	0	0	1	0	0	0	384	1696	59	5	2430	5	AGL	1	100347238	Missense_Mutation	SNP	T	TCGA-HD-7754-01A-11D-2078-08	14782899	100347238	148903383	5	55217											
SEMA4A	64218	broad.mit.edu	37	chr1	156130751	156130751	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggtcgtctacttcttcttCgaggagacagccagcgagtt	8	11	11	11	3	3	1	0	0	3	1	5	4	3	1	1	2	3	1	1	2	1	5			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr1:156130751C>T	uc001fnl.2	+	8	845	c.741C>T	c.(739-741)TTC>TTT	p.F247F	SEMA4A_uc009wrq.2_Silent_p.F247F|SEMA4A_uc001fnm.2_Silent_p.F247F|SEMA4A_uc001fnn.2_Silent_p.F115F|SEMA4A_uc001fno.2_Silent_p.F247F	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	247	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					ACTTCTTCTTCGAGGAGACAG	0.632													54	156					0	0	0	0	T	156130751	T	T	156130751	2	4	299	1	0	0	0	0	0	0	0	1	14096	883	31	1		1	SEMA4A	1	156130751	Silent	SNP	C	TCGA-HD-7754-01A-11D-2078-08	55783513	156130751	93119870	6	55218											
BCAN	63827	broad.mit.edu	37	chr1	156622478	156622478	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgagctatctggggtccctcGaggagagagcgaggagacag	10	6	17	8	2	1	3	0	1	1	2	3	8	2	4	1	4	2	1	1	4	1	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr1:156622478G>A	uc001fpp.2	+	8	2072	c.1736G>A	c.(1735-1737)CGA>CAA	p.R579Q	BCAN_uc001fpo.2_Missense_Mutation_p.R579Q	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	579					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGGTCCCTCGAGGAGAGAGC	0.642													18	30					0	0	0	0	A	156622478	A	A	156622478	3	1	299	1	0	0	0	0	1	0	0	0	1347	1058	37	1	1762	1	BCAN	1	156622478	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	491727	156622478	92628143	7	55219											
OR10X1	128367	broad.mit.edu	37	chr1	158549198	158549198	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ataaagaagcctgcagtgcaAgcagaggccacaagttgtcc	14	6	11	10	0	0	2	0	0	0	2	1	2	1	2	3	1	4	4	3	1	5	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr1:158549198A>C	uc010pin.1	-	1	492	c.492T>G	c.(490-492)GCT>GCG	p.A164A		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	164	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CTGCAGTGCAAGCAGAGGCCA	0.463													11	35					0	0	0	0	C	158549198	C	C	158549198	2	2	299	1	0	0	0	0	0	0	0	1	10976	59	3	5		5	OR10X1	1	158549198	Silent	SNP	A	TCGA-HD-7754-01A-11D-2078-08	1926720	158549198	90701423	8	55220											
ACTN2	88	broad.mit.edu	37	chr1	236912510	236912510	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcaacaattggatggagggCgctatggaggatctgcaaga	12	9	14	6	1	2	1	1	0	1	1	2	5	2	5	0	5	2	2	0	5	4	3			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr1:236912510C>T	uc001hyf.2	+	14	1806	c.1602C>T	c.(1600-1602)GGC>GGT	p.G534G	ACTN2_uc001hyg.2_Silent_p.G326G|ACTN2_uc009xgi.1_Silent_p.G534G|ACTN2_uc010pxu.1_Silent_p.G223G|ACTN2_uc001hyh.2_Silent_p.G222G	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	534	Spectrin 3.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GGATGGAGGGCGCTATGGAGG	0.443													9	48					0	0	0	0	T	236912510	T	T	236912510	2	4	299	1	0	0	0	0	0	0	0	1	205	755	27	1		1	ACTN2	1	236912510	Silent	SNP	C	TCGA-HD-7754-01A-11D-2078-08	78363312	236912510	12338111	9	55221											
THADA	63892	broad.mit.edu	37	chr2	43755035	43755035	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctgtttagtacttcagtGagtttcacaaaaccagtata	13	14	6	8	0	2	1	2	1	0	0	2	1	2	1	2	0	3	4	2	0	7	8			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr2:43755035G>A	uc002rsw.3	-	22	3709	c.3357C>T	c.(3355-3357)CTC>CTT	p.L1119L	THADA_uc010far.2_Silent_p.L388L|THADA_uc002rsx.3_Silent_p.L1119L|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Silent_p.L828L|THADA_uc010fat.1_Silent_p.L266L|THADA_uc002rta.2_Silent_p.L829L	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1119							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GTACTTCAGTGAGTTTCACAA	0.323													6	130					0	0	0	0	A	43755035	A	A	43755035	2	1	299	1	0	0	0	0	0	0	0	1	15906	1277	45	2		2	THADA	2	43755035	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08		43755035	199444338	10	55222											
C2orf86	51057	broad.mit.edu	37	chr2	63605643	63605645	+	Splice_Site	DEL	TGC	-	-																															ccaaggcttgtctcaagctgTgctgtggaattcaaacatag																										TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr2:63605643_63605645delTGC	uc002sch.2	-	12	2071	c.1625_splice	c.e12-1	p.A542_splice	C2orf86_uc002sce.2_Splice_Site|C2orf86_uc002scf.2_Splice_Site_p.A383_splice|C2orf86_uc010ypu.1_Splice_Site|C2orf86_uc002scg.2_Splice_Site_p.A350_splice|C2orf86_uc002sci.1_Splice_Site_p.A518_splice	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2						cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						TCTCAAGCTGTGCTGTGGAATTC	0.394													---	---	---								-	63605645	-	-	63605643	8	5	299	1	0	1	0	1	0	0	1	0	2211	1710	59	0	642	0	C2orf86	2	63605643	Splice_Site	DEL	TGC	TCGA-HD-7754-01A-11D-2078-08	19850608	63605643	179593730	11	55223											
TFCP2L1	29842	broad.mit.edu	37	chr2	121989537	121989537	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agctcttccaggaagatggcGtggtacactgggggaaggag	10	7	17	7	1	1	1	0	0	1	1	2	4	2	4	1	6	2	2	1	6	3	2	rs145068402		TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr2:121989537G>A	uc002tmx.2	-	13	1299	c.1206C>T	c.(1204-1206)CAC>CAT	p.H402H	TFCP2L1_uc010flr.2_Intron|TFCP2L1_uc010flq.2_Intron	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	402					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					GGAAGATGGCGTGGTACACTG	0.572													27	47					0	0	0	0	A	121989537	A	A	121989537	2	1	299	1	0	0	0	0	0	0	0	1	15862	1136	40	1		1	TFCP2L1	2	121989537	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08	58383894	121989537	121209836	12	55224											
LRP1B	53353	broad.mit.edu	37	chr2	141081592	141081592	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tttttaggtcctgctccataTatataatcttcaaagatatc	12	17	4	8	0	2	1	1	0	1	1	5	1	4	1	2	1	1	1	2	1	7	9			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr2:141081592T>C	uc002tvj.1	-	81	13356	c.12384A>G	c.(12382-12384)ATA>ATG	p.I4128M		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4128	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGCTCCATATATATAATCTT	0.294										TSP Lung(27;0.18)			26	39					0	0	0	0	C	141081592	C	C	141081592	3	2	299	1	0	0	0	0	1	0	0	0	9005	1396	49	5	1459	5	LRP1B	2	141081592	Missense_Mutation	SNP	T	TCGA-HD-7754-01A-11D-2078-08	19092055	141081592	102117781	13	55225											
TTN	7273	broad.mit.edu	37	chr2	179654722	179654722	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caccttctcctgagttatttGcacttgttctcttttggtag	5	19	7	10	0	2	1	0	1	2	0	4	1	2	1	2	1	1	4	2	1	2	8			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr2:179654722G>T	uc010zfg.1	-	12	2145	c.1921C>A	c.(1921-1923)CAA>AAA	p.Q641K	TTN_uc010zfh.1_Missense_Mutation_p.Q595K|TTN_uc010zfi.1_Missense_Mutation_p.Q595K|TTN_uc010zfj.1_Missense_Mutation_p.Q595K|TTN_uc002unb.2_Missense_Mutation_p.Q641K|TTN_uc010frg.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	641							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGTTATTTGCACTTGTTCT	0.328													12	48					1.5842e-08	1.68641e-08	1	0	T	179654722	T	T	179654722	3	4	299	1	0	0	0	0	1	0	0	0	16803	1328	46	4	109471	4	TTN	2	179654722	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	38573130	179654722	63544651	14	55226											
C2orf67	151050	broad.mit.edu	37	chr2	211018639	211018639	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgcttacacaatgaagtaaaCgagcatgtacttcctcctct	12	12	6	11	1	1	1	0	1	1	0	3	2	3	1	2	0	5	4	2	0	6	4			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr2:211018639C>T	uc002vds.2	-	2	876	c.668G>A	c.(667-669)CGT>CAT	p.R223H	C2orf67_uc002vdt.2_Missense_Mutation_p.R223H|C2orf67_uc002vdw.2_Missense_Mutation_p.R223H|C2orf67_uc002vdy.1_Missense_Mutation_p.R223H|C2orf67_uc002vdv.2_Missense_Mutation_p.R223H|C2orf67_uc002vdx.1_Missense_Mutation_p.R223H	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	223										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		ATGAAGTAAACGAGCATGTAC	0.403													24	66					0	0	0	0	T	211018639	T	T	211018639	3	4	299	1	0	0	0	0	1	0	0	0	2196	536	19	1	2351	1	C2orf67	2	211018639	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	31363917	211018639	32180734	15	55227											
OXTR	5021	broad.mit.edu	37	chr3	8794894	8794894	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggctggccaggagcatgacGatgatgaaggccgaggctga	11	5	17	8	2	0	4	0	4	0	0	0	7	0	5	2	5	1	3	2	5	1	0			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr3:8794894G>A	uc003brc.2	-	4	1561	c.939C>T	c.(937-939)ATC>ATT	p.I313I		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	313	Helical; Name=7; (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GGAGCATGACGATGATGAAGG	0.552													10	14					0	0	0	0	A	8794894	A	A	8794894	2	1	299	1	0	0	0	0	0	0	0	1	11392	1048	37	1		1	OXTR	3	8794894	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08		8794894	189227536	16	55228											
CACNA2D2	9254	broad.mit.edu	37	chr3	50418478	50418478	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgaagacctgccacagcagTgtggggtcttgtctgcggtt	6	10	14	11	2	2	1	0	0	2	1	2	2	2	1	3	3	3	2	3	3	1	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr3:50418478T>C	uc003daq.2	-	7	770	c.732A>G	c.(730-732)ACA>ACG	p.T244T	CACNA2D2_uc003dap.2_Silent_p.T244T	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	244	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	GCCACAGCAGTGTGGGGTCTT	0.607													36	62					0	0	0	0	C	50418478	C	C	50418478	2	2	299	1	0	0	0	0	0	0	0	1	2561	1683	59	5		5	CACNA2D2	3	50418478	Silent	SNP	T	TCGA-HD-7754-01A-11D-2078-08	41623584	50418478	147603952	17	55229											
AGTR1	185	broad.mit.edu	37	chr3	148459232	148459232	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcacccaatgaagtcccGccttcgacgcacaatgcttg	9	10	8	14	3	1	1	1	1	0	0	3	2	2	1	3	0	1	3	3	0	3	3	rs56257794		TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr3:148459232G>A	uc003ewg.2	+	4	856	c.410G>A	c.(409-411)CGC>CAC	p.R137H	AGTR1_uc003ewh.2_Missense_Mutation_p.R137H|AGTR1_uc003ewi.2_Missense_Mutation_p.R137H|AGTR1_uc003ewj.2_Missense_Mutation_p.R137H|AGTR1_uc003ewk.2_Missense_Mutation_p.R137H	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	137	Cytoplasmic (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	ATGAAGTCCCGCCTTCGACGC	0.488													45	151					0	0	0	0	A	148459232	A	A	148459232	3	1	299	1	0	0	0	0	1	0	0	0	401	1087	38	1	412	1	AGTR1	3	148459232	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	98040754	148459232	49563198	18	55230											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			16	52					0	0	0	0	A	178936082	A	A	178936082	3	1	299	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	30476850	178936082	19086348	19	55231											
PI4K2B	55300	broad.mit.edu	37	chr4	25258218	25258218	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aatgcgattgaccgtgcaaaAtcaagaggcaaaaagtatgc	17	7	10	7	2	1	2	1	1	0	1	1	3	1	2	1	1	3	3	1	1	7	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr4:25258218A>G	uc003grk.2	+	4	811	c.678A>G	c.(676-678)AAA>AAG	p.K226K	PI4K2B_uc011bxs.1_Silent_p.K130K	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta	226	PI3K/PI4K.					cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			ovary(2)|skin(2)	4		Breast(46;0.173)				ACCGTGCAAAATCAAGAGGCA	0.363													28	57					0	0	0	0	G	25258218	G	G	25258218	2	3	299	1	0	0	0	0	0	0	0	1	11927	98	4	5		5	PI4K2B	4	25258218	Silent	SNP	A	TCGA-HD-7754-01A-11D-2078-08		25258218	165896058	20	55232											
TLR10	81793	broad.mit.edu	37	chr4	38776633	38776633	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccattggtaaaacaatgtgCagttttgttgtgtttaagat	11	17	9	4	0	0	1	0	0	0	1	1	1	1	1	1	1	2	5	1	1	4	7			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr4:38776633C>A	uc003gti.2	-	2	958	c.579G>T	c.(577-579)CTG>CTT	p.L193L	TLR10_uc003gtj.2_Silent_p.L193L|TLR10_uc003gtk.2_Silent_p.L193L	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	193	Extracellular (Potential).				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						AAACAATGTGCAGTTTTGTTG	0.358													21	45					7.41877e-09	7.98324e-09	1	0	A	38776633	A	A	38776633	2	1	299	1	0	0	0	0	0	0	0	1	16016	697	25	4		4	TLR10	4	38776633	Silent	SNP	C	TCGA-HD-7754-01A-11D-2078-08	13518415	38776633	152377643	21	55233											
POLR2B	5431	broad.mit.edu	37	chr4	57889516	57889516	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcatgaggcatgccatttacGacaagctggatgatgatggt	11	10	13	7	1	0	3	0	3	0	0	0	5	0	4	1	3	3	3	1	3	2	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr4:57889516G>A	uc003hcl.1	+	19	2579	c.2536G>A	c.(2536-2538)GAC>AAC	p.D846N	POLR2B_uc011cae.1_Missense_Mutation_p.D839N|POLR2B_uc011caf.1_Missense_Mutation_p.D771N|POLR2B_uc003hcm.1_Missense_Mutation_p.D339N	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	846					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					TGCCATTTACGACAAGCTGGA	0.418													10	29					0	0	0	0	A	57889516	A	A	57889516	3	1	299	1	0	0	0	0	1	0	0	0	12270	1058	37	1	2610	1	POLR2B	4	57889516	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	19112883	57889516	133264760	22	55234											
GC	2638	broad.mit.edu	37	chr4	72629179	72629179	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	attgtgagcagactctatttGacagagtggtgagaagtgat	12	12	13	4	0	1	6	0	4	1	3	1	7	1	6	0	1	1	1	0	1	2	3			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr4:72629179G>T	uc003hge.2	-	6	800	c.647C>A	c.(646-648)TCA>TAA	p.S216*	GC_uc003hgd.2_Nonsense_Mutation_p.S94*|GC_uc010iie.2_Nonsense_Mutation_p.S216*|GC_uc010iif.2_Nonsense_Mutation_p.S235*	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	216	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GACTCTATTTGACAGAGTGGT	0.358													24	48					1.17739e-12	1.2809e-12	1	0	T	72629179	T	T	72629179	4	4	299	1	0	0	0	0	0	1	0	0	6317	1294	45	2	805	2	GC	4	72629179	Nonsense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	14739663	72629179	118525097	23	55235											
KIAA1109	84162	broad.mit.edu	37	chr4	123176339	123176339	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaacaggcttacaaaagtTgctcgctttctccaagaaaa	15	10	6	10	1	1	1	0	0	1	1	3	1	1	1	1	1	4	4	1	1	8	4			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr4:123176339T>C	uc003ieh.2	+	38	6324	c.6279T>C	c.(6277-6279)GTT>GTC	p.V2093V	KIAA1109_uc003iel.1_Silent_p.V28V|KIAA1109_uc003iek.2_Silent_p.V712V	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2093					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTACAAAAGTTGCTCGCTTTC	0.338													5	53					0	0	0	0	C	123176339	C	C	123176339	2	2	299	1	0	0	0	0	0	0	0	1	8247	1799	63	5		5	KIAA1109	4	123176339	Silent	SNP	T	TCGA-HD-7754-01A-11D-2078-08	50547160	123176339	67977937	24	55236											
NPR3	4883	broad.mit.edu	37	chr5	32712195	32712195	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcttccaggtggcttacgagGattcagactgtgggaaccgt	8	10	14	9	2	1	1	1	0	0	1	2	4	2	3	2	4	2	2	2	4	2	3			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr5:32712195G>A	uc003jhv.2	+	1	531	c.313G>A	c.(313-315)GAT>AAT	p.D105N	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Missense_Mutation_p.D105N	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	105	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GGCTTACGAGGATTCAGACTG	0.682													25	44					0	0	0	0	A	32712195	A	A	32712195	3	1	299	1	0	0	0	0	1	0	0	0	10650	1174	41	2	315	2	NPR3	5	32712195	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08		32712195	148203065	25	55237											
VCAN	1462	broad.mit.edu	37	chr5	82834751	82834751	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccatctacagtacctactTcagttcacatcagtcacata	13	11	3	14	0	5	0	4	0	1	0	5	0	5	0	2	0	3	2	2	0	4	6			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr5:82834751T>C	uc003kii.3	+	8	6285	c.5929T>C	c.(5929-5931)TCA>CCA	p.S1977P	VCAN_uc003kij.3_Missense_Mutation_p.S990P|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.S641P	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1977	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AGTACCTACTTCAGTTCACAT	0.488													13	31					0	0	0	0	C	82834751	C	C	82834751	3	2	299	1	0	0	0	0	1	0	0	0	17206	1783	62	5	5955	5	VCAN	5	82834751	Missense_Mutation	SNP	T	TCGA-HD-7754-01A-11D-2078-08	50122556	82834751	98080509	26	55238											
TMEM184A	202915	broad.mit.edu	37	chr7	1595084	1595084	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttcgctgacaccagggggaCgccggctgtctccaggatcc	6	7	14	14	3	1	1	0	1	1	0	4	3	2	3	4	4	0	3	4	4	0	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr7:1595084C>T	uc003skv.3	-	2	354	c.37G>A	c.(37-39)GTC>ATC	p.V13I	TMEM184A_uc003skw.3_5'UTR	NM_001097620	NP_001091089	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	13						integral to membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		ACCAGGGGGACGCCGGCTGTC	0.677													19	32					0	0	0	0	T	1595084	T	T	1595084	3	4	299	1	0	0	0	0	1	0	0	0	16170	536	19	1	1236	1	TMEM184A	7	1595084	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08		1595084	157543579	27	55239											
TAX1BP1	8887	broad.mit.edu	37	chr7	27831655	27831655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttttttaaaggagcaacttCgtaaagcagaggaacaggtt	14	11	11	5	1	0	1	0	0	0	1	1	3	0	3	0	3	4	5	0	3	6	6			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr7:27831655C>T	uc003szl.2	+	9	1227	c.1069C>T	c.(1069-1071)CGT>TGT	p.R357C	TAX1BP1_uc011jzo.1_Missense_Mutation_p.R357C|TAX1BP1_uc003szk.2_Missense_Mutation_p.R357C|TAX1BP1_uc011jzp.1_Missense_Mutation_p.R200C	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	357	Oligomerization.|Potential.				anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			GGAGCAACTTCGTAAAGCAGA	0.388													14	30					0	0	0	0	T	27831655	T	T	27831655	3	4	299	1	0	0	0	0	1	0	0	0	15660	884	31	1	1099	1	TAX1BP1	7	27831655	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	26236571	27831655	131307008	28	55240											
KIAA1549	57670	broad.mit.edu	37	chr7	138591668	138591668	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagagggctgtactcacgctCtgcgatctgcagcactgggt	8	9	13	11	2	3	1	1	0	2	1	3	2	3	1	0	2	4	5	0	2	2	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr7:138591668C>T	uc011kql.1	-	6	3506	c.3457G>A	c.(3457-3459)GAG>AAG	p.E1153K	KIAA1549_uc003vuk.3_Missense_Mutation_p.E1103K|KIAA1549_uc011kqj.1_Missense_Mutation_p.E1153K	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1153						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TACTCACGCTCTGCGATCTGC	0.468			O	BRAF	pilocytic astrocytoma								20	31					0	0	0	0	T	138591668	T	T	138591668	3	4	299	1	0	0	0	0	1	0	0	0	8283	922	32	2	2455	2	KIAA1549	7	138591668	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	110760013	138591668	20546995	29	55241											
AGK	55750	broad.mit.edu	37	chr7	141315304	141315304	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	agattcccattggatttatcCcactgggagagaccagtagt	11	11	10	9	0	0	2	0	0	0	2	2	5	2	4	3	2	0	1	3	2	2	5			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr7:141315304C>T	uc003vwi.2	+	8	628	c.457C>T	c.(457-459)CCA>TCA	p.P153S	AGK_uc011krg.1_RNA	NM_018238	NP_060708	Q53H12	AGK_HUMAN	acylglycerol kinase precursor	153	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			ovary(1)|breast(1)	2	Melanoma(164;0.0171)					TGGATTTATCCCACTGGGAGA	0.443													54	112					0	0	0	0	T	141315304	T	T	141315304	3	4	299	1	0	0	0	0	1	0	0	0	383	623	22	4	483	4	AGK	7	141315304	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	2723636	141315304	17823359	30	55242											
ENTPD4	9583	broad.mit.edu	37	chr8	23290623	23290623	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagacaaaggaaacgcccCgccagtgggtgtgactggct	10	7	14	10	2	0	2	0	1	0	1	0	3	0	3	3	3	1	2	3	3	3	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr8:23290623C>T	uc003xdl.2	-	13	1831	c.1667G>A	c.(1666-1668)CGG>CAG	p.R556Q	ENTPD4_uc011kzu.1_Intron|ENTPD4_uc003xdm.2_Missense_Mutation_p.R548Q	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	556	Lumenal (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		GGAAACGCCCCGCCAGTGGGT	0.582													9	15					0	0	0	0	T	23290623	T	T	23290623	3	4	299	1	0	0	0	0	1	0	0	0	5165	652	23	1	187	1	ENTPD4	8	23290623	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08		23290623	123073399	31	55243											
NECAB1	64168	broad.mit.edu	37	chr8	91967721	91967721	+	Frame_Shift_Del	DEL	G	-	-																															ttttctcttttcagcttcgtGgtggatcctgaacaactaga																										TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr8:91967721delG	uc011lgg.1	+	13	1231	c.1037delG	c.(1036-1038)TGGfs	p.W346fs	NECAB1_uc003yer.2_Frame_Shift_Del_p.W95fs	NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	346					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			TCAGCTTCGTGGTGGATCCTG	0.338													---	---	---								-	91967721	-	-	91967721	7	5	299	1	0	1	0	1	0	0	0	0	10358	1357	47	0	1087	0	NECAB1	8	91967721	Frame_Shift_Del	DEL	G	TCGA-HD-7754-01A-11D-2078-08	68677098	91967721	54396301	32	55244											
DEPDC6	64798	broad.mit.edu	37	chr8	120977572	120977572	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aattcctggactggctggttCaggaaggtgaggccaccacg	9	8	14	10	1	1	1	1	1	0	0	2	3	2	3	3	6	0	2	3	6	2	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr8:120977572C>A	uc003yow.3	+	4	713	c.526C>A	c.(526-528)CAG>AAG	p.Q176K	DEPDC6_uc011lid.1_Missense_Mutation_p.Q75K	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	176	DEP 2.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CTGGCTGGTTCAGGAAGGTGA	0.527													12	43					0.000151284	0.000157654	1	0	A	120977572	A	A	120977572	3	1	299	1	0	0	0	0	1	0	0	0	4465	827	29	2	540	2	DEPDC6	8	120977572	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	29009851	120977572	25386450	33	55245											
EPPK1	83481	broad.mit.edu	37	chr8	144941384	144941384	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtcgatgacaccccccGtggccacctgcacctccagc	6	6	11	18	2	0	1	0	1	0	0	2	2	1	1	7	2	2	1	7	2	0	0			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr8:144941384G>A	uc003zaa.1	-	1	6051	c.6038C>T	c.(6037-6039)ACG>ATG	p.T2013M		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2013	Plectin 34.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GACACCCCCCGTGGCCACCTG	0.627													9	18					0	0	0	0	A	144941384	A	A	144941384	3	1	299	1	0	0	0	0	1	0	0	0	5214	1145	40	1	1228	1	EPPK1	8	144941384	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	23963812	144941384	1422638	34	55246											
JAK2	3717	broad.mit.edu	37	chr9	5065041	5065041	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aactgtcatggcccaatttcGtgagtaatacagacttaaaa	15	11	7	8	1	1	2	1	1	0	1	2	2	1	2	1	1	2	1	1	1	6	4			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr9:5065041G>A	uc010mhm.2	+	8	1327	c.1214_splice	c.e8+1	p.S405_splice	JAK2_uc003ziw.2_Splice_Site_p.S405_splice	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2						actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		GCCCAATTTCGTGAGTAATAC	0.313		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				11	6					0	0	0	0	A	5065041	A	A	5065041	5	1	299	1	0	0	0	0	0	0	1	0	7977	1159	40	1	1241	1	JAK2	9	5065041	Splice_Site	SNP	G	TCGA-HD-7754-01A-11D-2078-08		5065041	136148390	35	55247											
TMEM8B	51754	broad.mit.edu	37	chr9	35853517	35853517	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccagacagtacgcagcgtcCgccgccggcactgctaccca	8	4	10	19	5	0	1	0	0	0	1	1	1	1	1	5	1	4	4	5	1	2	2	rs148540551	by1000genomes	TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr9:35853517C>T	uc003zym.2	+	14	2114	c.1099C>T	c.(1099-1101)CGC>TGC	p.R367C	TMEM8B_uc003zyo.2_Missense_Mutation_p.R367C	NM_001042589	NP_001036054	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B isoform a	367	Cytoplasmic (Potential).				cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			ovary(1)	1						ACGCAGCGTCCGCCGCCGGCA	0.597													14	8					0	0	0	0	T	35853517	T	T	35853517	3	4	299	1	0	0	0	0	1	0	0	0	16281	652	23	1	1327	1	TMEM8B	9	35853517	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	30788476	35853517	105359914	36	55248											
UBQLN1	29979	broad.mit.edu	37	chr9	86322560	86322560	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	cggcggcgctatcctgggagCccggaggaccgccgctttca	5	6	15	15	6	1	0	1	0	0	0	2	3	2	3	4	5	1	2	4	5	1	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr9:86322560C>T	uc004amv.2	-	1	609	c.35G>A	c.(34-36)GGC>GAC	p.G12D	UBQLN1_uc004amw.2_Missense_Mutation_p.G12D|uc004amx.2_5'Flank	NM_013438	NP_038466	Q9UMX0	UBQL1_HUMAN	ubiquilin 1 isoform 1	12					apoptosis|regulation of protein ubiquitination|response to hypoxia	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm|proteasome complex	kinase binding				0						ATCCTGGGAGCCCGGAGGACC	0.706													4	2					0	0	0	0	T	86322560	T	T	86322560	3	4	299	1	0	0	0	0	1	0	0	0	16964	739	26	4	1778	4	UBQLN1	9	86322560	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	50469043	86322560	54890871	37	55249											
NFIL3	4783	broad.mit.edu	37	chr9	94171927	94171927	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcactatgcttttcgagttCgaaatgtcttttagatgtca	9	16	9	7	2	2	1	1	0	1	1	4	3	2	1	0	1	1	3	0	1	3	6	rs34945709		TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr9:94171927C>T	uc004arh.2	-	2	1485	c.1090G>A	c.(1090-1092)GAA>AAA	p.E364K		NM_005384	NP_005375	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	364					circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						TTTTCGAGTTCGAAATGTCTT	0.408													38	89					0	0	0	0	T	94171927	T	T	94171927	3	4	299	1	0	0	0	0	1	0	0	0	10427	893	31	1	302	1	NFIL3	9	94171927	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	7849367	94171927	47041504	38	55250											
C10orf10	11067	broad.mit.edu	37	chr10	45473220	45473220	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctgctggccactgaaacgtgCggtgatgtctcgcagggaca	8	8	14	11	3	1	2	0	2	1	0	2	3	1	3	1	3	3	2	1	3	1	0			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr10:45473220C>T	uc001jbr.3	-	2	549	c.259G>A	c.(259-261)GCA>ACA	p.A87T	RASSF4_uc001jbo.2_Intron|RASSF4_uc001jbp.2_Intron|RASSF4_uc009xmn.2_Intron|RASSF4_uc001jbq.2_Intron	NM_007021	NP_008952	Q9NTK1	DEPP_HUMAN	fasting-induced protein	87						mitochondrion					0						CTGAAACGTGCGGTGATGTCT	0.667													12	28					0	0	0	0	T	45473220	T	T	45473220	3	4	299	1	0	0	0	0	1	0	0	0	1585	768	27	1	383	1	C10orf10	10	45473220	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08		45473220	90061527	39	55251											
TACC2	10579	broad.mit.edu	37	chr10	123970459	123970459	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagaatctagcatctgagacGaaaacggaatctgccaagac	16	6	10	9	2	3	3	0	1	3	3	3	7	3	4	1	1	3	1	1	1	6	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr10:123970459G>A	uc001lfv.2	+	9	6879	c.6519G>A	c.(6517-6519)ACG>ACA	p.T2173T	TACC2_uc001lfw.2_Silent_p.T319T|TACC2_uc009xzx.2_Silent_p.T2128T|TACC2_uc010qtv.1_Silent_p.T2177T|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Silent_p.T251T|TACC2_uc001lga.2_Silent_p.T251T|TACC2_uc009xzy.2_Silent_p.T251T|TACC2_uc001lgb.2_Silent_p.T208T|TACC2_uc010qtw.1_Silent_p.T268T	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2173						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CATCTGAGACGAAAACGGAAT	0.592													36	63					0	0	0	0	A	123970459	A	A	123970459	2	1	299	1	0	0	0	0	0	0	0	1	15568	1045	37	1		1	TACC2	10	123970459	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08	78497239	123970459	11564288	40	55252											
ANO5	203859	broad.mit.edu	37	chr11	22281076	22281076	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctttcccagatgtctcttgtCgtcaccagtatggtagctgt	6	15	9	11	1	2	1	1	0	1	1	5	1	3	1	2	1	1	3	2	1	2	4			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr11:22281076C>T	uc001mqi.2	+	15	1736	c.1419C>T	c.(1417-1419)GTC>GTT	p.V473V	ANO5_uc001mqj.2_Silent_p.V472V	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	473	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TGTCTCTTGTCGTCACCAGTA	0.383													29	35					0	0	0	0	T	22281076	T	T	22281076	2	4	299	1	0	0	0	0	0	0	0	1	700	871	31	1		1	ANO5	11	22281076	Silent	SNP	C	TCGA-HD-7754-01A-11D-2078-08		22281076	112725440	41	55253											
BSCL2	26580	broad.mit.edu	37	chr11	62458817	62458817	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatgtagctgaagagcaCgatgacgctgaggaaggtga	12	7	15	7	2	0	5	0	4	0	1	0	7	0	6	0	2	3	5	0	2	3	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr11:62458817C>T	uc001nuo.1	-	7	1172	c.748G>A	c.(748-750)GTG>ATG	p.V250M	LRRN4CL_uc001nun.2_5'Flank|BSCL2_uc009yoc.1_Intron|BSCL2_uc001nup.2_Missense_Mutation_p.V250M|BSCL2_uc001nuq.1_Missense_Mutation_p.V250M|BSCL2_uc001nur.3_Missense_Mutation_p.V314M|BSCL2_uc009yod.2_Missense_Mutation_p.V314M|BSCL2_uc001nut.3_Missense_Mutation_p.V314M|HNRNPUL2_uc001nuu.1_RNA	NM_032667	NP_116056	Q96G97	BSCL2_HUMAN	seipin isoform 2	250	Helical; (Potential).				cell death	integral to endoplasmic reticulum membrane					0						CTGAAGAGCACGATGACGCTG	0.562													14	27					0	0	0	0	T	62458817	T	T	62458817	3	4	299	1	0	0	0	0	1	0	0	0	1532	536	19	1	468	1	BSCL2	11	62458817	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	40177741	62458817	72547699	42	55254											
ATM	472	broad.mit.edu	37	chr11	108153603	108153603	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cacaaatattgaggatttctAtaggtaagtttatacatgac	15	14	7	5	0	1	2	0	2	1	0	1	3	1	3	0	2	1	2	0	2	7	9			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr11:108153603A>G	uc001pkb.1	+	25	4128	c.3743A>G	c.(3742-3744)TAT>TGT	p.Y1248C	ATM_uc009yxr.1_Missense_Mutation_p.Y1248C	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1248					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GAGGATTTCTATAGGTAAGTT	0.294			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			3	8					0	0	0	0	G	108153603	G	G	108153603	3	3	299	1	0	0	0	0	1	0	0	0	1111	449	16	5	3837	5	ATM	11	108153603	Missense_Mutation	SNP	A	TCGA-HD-7754-01A-11D-2078-08	45694786	108153603	26852913	43	55255											
ADAMTS8	11095	broad.mit.edu	37	chr11	130275690	130275690	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctctgcatgctaaagtccacGtcattaggaacaaagaaggt	14	9	9	9	1	2	1	1	0	1	1	3	2	3	2	1	2	3	2	1	2	6	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr11:130275690G>A	uc001qgg.3	-	9	2791	c.2433C>T	c.(2431-2433)GAC>GAT	p.D811D	ADAMTS8_uc001qgf.2_Silent_p.D292D	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	811	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TAAAGTCCACGTCATTAGGAA	0.567													57	105					0	0	0	0	A	130275690	A	A	130275690	2	1	299	1	0	0	0	0	0	0	0	1	272	1136	40	1		1	ADAMTS8	11	130275690	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08	22122087	130275690	4730826	44	55256											
SPSB2	84727	broad.mit.edu	37	chr12	6981424	6981424	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctcctttcgcccaggtagcgGatgcggacctggcactggcc	5	8	13	15	3	0	0	0	0	0	0	2	2	1	2	4	5	2	2	4	5	1	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr12:6981424G>A	uc001qrl.2	-	2	798	c.642C>T	c.(640-642)ATC>ATT	p.I214I	SPSB2_uc001qrm.2_Silent_p.I214I|SPSB2_uc010sfp.1_Silent_p.I214I|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	214	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1						CCAGGTAGCGGATGCGGACCT	0.617											OREG0021639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	148	113					0	0	0	0	A	6981424	A	A	6981424	2	1	299	1	0	0	0	0	0	0	0	1	15179	1164	41	2		2	SPSB2	12	6981424	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08		6981424	126870471	45	55257											
RARG	5916	broad.mit.edu	37	chr12	53609209	53609209	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gttcttctggatgcttcggcGaaagaagccctggagttgag	8	11	14	8	2	2	2	0	1	2	1	3	5	2	4	1	3	2	3	1	3	2	4			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr12:53609209G>A	uc001sce.2	-	5	828	c.343C>T	c.(343-345)CGC>TGC	p.R115C	RARG_uc001scd.2_Missense_Mutation_p.R104C|RARG_uc010sob.1_Missense_Mutation_p.R93C|RARG_uc001scf.2_Missense_Mutation_p.R115C|RARG_uc001scg.2_Missense_Mutation_p.R43C|RARG_uc010soc.1_5'UTR|RARG_uc010sod.1_Missense_Mutation_p.R152C	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	115	Nuclear receptor.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	ATGCTTCGGCGAAAGAAGCCC	0.552													20	35					0	0	0	0	A	53609209	A	A	53609209	3	1	299	1	0	0	0	0	1	0	0	0	13119	1058	37	1	1045	1	RARG	12	53609209	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	46627785	53609209	80242686	46	55258											
DHX37	57647	broad.mit.edu	37	chr12	125441262	125441262	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cagctcctcaaacagctcccGcaccgtcatgctggccacga	9	6	8	18	3	2	0	2	0	0	0	4	1	4	0	4	1	4	4	4	1	1	0			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr12:125441262G>A	uc001ugy.2	-	18	2527	c.2428C>T	c.(2428-2430)CGG>TGG	p.R810W		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	810							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		AACAGCTCCCGCACCGTCATG	0.617													19	35					0	0	0	0	A	125441262	A	A	125441262	3	1	299	1	0	0	0	0	1	0	0	0	4532	1086	38	1	1085	1	DHX37	12	125441262	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	71832053	125441262	8410633	47	55259											
ZMYM5	9205	broad.mit.edu	37	chr13	20412924	20412924	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagagcaaaagaggtgagctGatccttttcgttgataagct	12	12	11	6	1	0	5	0	3	0	2	2	5	1	5	1	1	3	4	1	1	4	5			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr13:20412924G>A	uc010tcn.1	-	5	1053	c.788C>T	c.(787-789)TCA>TTA	p.S263L	ZMYM5_uc001umm.1_Missense_Mutation_p.S87L|ZMYM5_uc001umn.2_Missense_Mutation_p.S263L|ZMYM5_uc001umo.2_Intron	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	263						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		GAGGTGAGCTGATCCTTTTCG	0.403													51	83					0	0	0	0	A	20412924	A	A	20412924	3	1	299	1	0	0	0	0	1	0	0	0	17770	1294	45	2	1348	2	ZMYM5	13	20412924	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08		20412924	94756954	48	55260											
SCEL	8796	broad.mit.edu	37	chr13	78176794	78176794	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgttttttccaaagaagacAaaatctcgaatctgttgcta	13	14	7	7	1	2	2	0	0	2	2	4	3	3	2	1	0	1	3	1	0	6	5			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr13:78176794A>G	uc001vki.2	+	17	1153	c.983A>G	c.(982-984)CAA>CGA	p.Q328R	SCEL_uc001vkj.2_Missense_Mutation_p.Q308R|SCEL_uc010thx.1_Missense_Mutation_p.Q306R	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	328	16 X approximate tandem repeats.|5.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		CAAAGAAGACAAAATCTCGAA	0.358													21	54					0	0	0	0	G	78176794	G	G	78176794	3	3	299	1	0	0	0	0	1	0	0	0	13953	130	5	5	1045	5	SCEL	13	78176794	Missense_Mutation	SNP	A	TCGA-HD-7754-01A-11D-2078-08	57763870	78176794	36993084	49	55261											
AKAP6	9472	broad.mit.edu	37	chr14	33292161	33292161	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagaacaagatcccggaatcGaatgcatcgttcaggaagcg	15	6	11	9	4	1	2	1	0	0	2	4	5	2	4	1	2	3	2	1	2	6	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr14:33292161G>A	uc001wrq.2	+	13	5312	c.5142G>A	c.(5140-5142)TCG>TCA	p.S1714S		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1714					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCCCGGAATCGAATGCATCGT	0.468													24	51					0	0	0	0	A	33292161	A	A	33292161	2	1	299	1	0	0	0	0	0	0	0	1	455	1045	37	1		1	AKAP6	14	33292161	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08		33292161	74057379	50	55262											
ZFP36L1	677	broad.mit.edu	37	chr14	69257045	69257046	+	Frame_Shift_Ins	INS	-	T	T																															agctcagagcgggggctggcINStcacccttgaggctgctgag																										TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr14:69257045_69257046insT	uc001xkh.1	-	2	351_352	c.221_222insA	c.(220-222)GAGfs	p.E74fs	ZFP36L1_uc001xki.1_Frame_Shift_Ins_p.E74fs	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	74					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CGGGGGCTGGCTCACCCTTGAG	0.698											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---								T	69257046	T	T	69257045	7	5	299	1	0	1	1	0	0	0	0	0	17713	796	28	0	798	0	ZFP36L1	14	69257045	Frame_Shift_Ins	INS	-	TCGA-HD-7754-01A-11D-2078-08	35964884	69257045	38092495	51	55263											
SPTBN5	51332	broad.mit.edu	37	chr15	42169045	42169045	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggctctgaaccagcttctcGccgtgtgcccgcagagcctc	5	9	11	16	3	2	2	0	1	2	1	4	2	2	2	4	1	4	3	4	1	1	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr15:42169045G>A	uc001zos.2	-	19	4041	c.3708C>T	c.(3706-3708)GGC>GGT	p.G1236G		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1271	Spectrin 9.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CCAGCTTCTCGCCGTGTGCCC	0.672													8	20					0	0	0	0	A	42169045	A	A	42169045	2	1	299	1	0	0	0	0	0	0	0	1	15188	1074	38	1		1	SPTBN5	15	42169045	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08		42169045	60362347	52	55264											
TMEM62	80021	broad.mit.edu	37	chr15	43452910	43452910	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaagtaagagtgttcaccAcatattttctgttcaagaga	15	12	8	6	0	3	3	2	0	1	3	3	4	3	3	1	0	0	3	1	0	5	6			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr15:43452910A>G	uc001zqr.2	+	10	1493	c.1214A>G	c.(1213-1215)CAC>CGC	p.H405R	TMEM62_uc010bda.2_Missense_Mutation_p.H275R|TMEM62_uc001zqt.2_5'UTR	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	405						integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		AGTGTTCACCACATATTTTCT	0.318													13	56					0	0	0	0	G	43452910	G	G	43452910	3	3	299	1	0	0	0	0	1	0	0	0	16255	159	6	5	1252	5	TMEM62	15	43452910	Missense_Mutation	SNP	A	TCGA-HD-7754-01A-11D-2078-08	1283865	43452910	59078482	53	55265											
CATSPER2	117155	broad.mit.edu	37	chr15	43931101	43931101	+	Splice_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgtccccagctctgcttaCgagaagaacacatggtactc	10	9	9	13	1	1	2	0	0	1	2	3	3	2	2	2	1	5	4	2	1	4	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr15:43931101C>T	uc001zsh.2	-	7	1057	c.842_splice	c.e7+1	p.S281_splice	CATSPER2_uc010bdm.2_Splice_Site|CATSPER2_uc001zsi.2_Splice_Site_p.S281_splice|CATSPER2_uc001zsj.2_Splice_Site_p.S281_splice	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2						cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GCTCTGCTTACGAGAAGAACA	0.463													22	17					0	0	0	0	T	43931101	T	T	43931101	5	4	299	1	0	0	0	0	0	0	1	0	2700	550	19	1	777	1	CATSPER2	15	43931101	Splice_Site	SNP	C	TCGA-HD-7754-01A-11D-2078-08	478191	43931101	58600291	54	55266											
MAPK6	5597	broad.mit.edu	37	chr15	52350913	52350913	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	atcgtcaggagcttctcagcGtaattccagtttacattaga	11	13	8	9	2	2	1	2	0	1	1	5	2	3	2	1	1	3	3	1	1	3	6			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr15:52350913G>A	uc002abp.2	+	4	1578	c.784G>A	c.(784-786)GTA>ATA	p.V262I		NM_002748	NP_002739	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	262	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(3)|ovary(1)	4				all cancers(107;0.0028)		GCTTCTCAGCGTAATTCCAGT	0.408													11	19					0	0	0	0	A	52350913	A	A	52350913	3	1	299	1	0	0	0	0	1	0	0	0	9334	1145	40	1	794	1	MAPK6	15	52350913	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	8419812	52350913	50180479	55	55267											
DNAH3	55567	broad.mit.edu	37	chr16	20999297	20999297	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcaaaccctttcccgaagTgccagtcaacaatcgaactg	13	8	6	14	2	2	0	2	0	0	0	4	2	3	0	3	0	4	0	3	0	5	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr16:20999297T>C	uc010vbe.1	-	45	6692	c.6692A>G	c.(6691-6693)CAC>CGC	p.H2231R	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2231	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTTCCCGAAGTGCCAGTCAAC	0.448													9	33					0	0	0	0	C	20999297	C	C	20999297	3	2	299	1	0	0	0	0	1	0	0	0	4625	1696	59	5	5729	5	DNAH3	16	20999297	Missense_Mutation	SNP	T	TCGA-HD-7754-01A-11D-2078-08		20999297	69355456	56	55268											
POLR3E	55718	broad.mit.edu	37	chr16	22324968	22324968	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ccacctgacacctttacatgGcatcctgcagctgcggccca	8	8	8	17	1	0	1	0	1	0	0	1	1	1	1	5	2	4	3	5	2	1	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr16:22324968G>A	uc002dkk.2	+	7	548	c.392G>A	c.(391-393)GGC>GAC	p.G131D	POLR3E_uc002dkj.1_Missense_Mutation_p.G131D|POLR3E_uc002dkm.2_Missense_Mutation_p.G95D|POLR3E_uc010vbr.1_Missense_Mutation_p.G131D|POLR3E_uc002dkl.2_Missense_Mutation_p.G131D|POLR3E_uc010vbs.1_Missense_Mutation_p.G95D|POLR3E_uc010vbt.1_Missense_Mutation_p.G75D	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	131					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		CCTTTACATGGCATCCTGCAG	0.612													3	39					0	0	0	0	A	22324968	A	A	22324968	3	1	299	1	0	0	0	0	1	0	0	0	12287	1203	42	4	414	4	POLR3E	16	22324968	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	1325671	22324968	68029785	57	55269											
CACNG3	10368	broad.mit.edu	37	chr16	24366272	24366272	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cacaacgtcattctcagcgcGggcatcttttttgtctctgc	6	14	8	13	3	4	0	2	0	3	0	6	0	4	0	0	1	3	1	0	1	1	4			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr16:24366272G>A	uc002dmf.2	+	3	1614	c.414G>A	c.(412-414)GCG>GCA	p.A138A		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	138	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		TTCTCAGCGCGGGCATCTTTT	0.572													6	25					0	0	0	0	A	24366272	A	A	24366272	2	1	299	1	0	0	0	0	0	0	0	1	2570	1103	39	1		1	CACNG3	16	24366272	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08	2041304	24366272	65988481	58	55270											
C16orf58	64755	broad.mit.edu	37	chr16	31510704	31510704	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctcaaggaacatggctacGtcattgaggatgtccgcaaa	13	9	10	9	2	2	1	2	1	1	0	4	3	3	3	1	3	2	2	1	3	4	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr16:31510704G>A	uc002eci.1	-	5	531	c.519C>T	c.(517-519)GAC>GAT	p.D173D	C16orf58_uc010vfq.1_Silent_p.D31D	NM_022744	NP_073581	Q96GQ5	CP058_HUMAN	hypothetical protein LOC64755	173						integral to membrane				ovary(1)|breast(1)	2						ACATGGCTACGTCATTGAGGA	0.547													19	24					0	0	0	0	A	31510704	A	A	31510704	2	1	299	1	0	0	0	0	0	0	0	1	1828	1136	40	1		1	C16orf58	16	31510704	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08	7144432	31510704	58844049	59	55271											
KRT40	125115	broad.mit.edu	37	chr17	39135155	39135155	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtactcctggttctgtcgcTccaggtcgcagcggatctcg	4	11	13	13	4	2	0	0	0	2	0	7	1	4	1	2	4	2	4	2	4	1	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr17:39135155T>A	uc010cxh.1	-	8	1258	c.1097A>T	c.(1096-1098)GAG>GTG	p.E366V	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	366	Rod.|Coil 2.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				GTTCTGTCGCTCCAGGTCGCA	0.617													24	56					0	0	0	0	A	39135155	A	A	39135155	3	1	299	1	0	0	0	0	1	0	0	0	8517	1551	54	5	206	5	KRT40	17	39135155	Missense_Mutation	SNP	T	TCGA-HD-7754-01A-11D-2078-08		39135155	42060055	60	55272											
NPC1	4864	broad.mit.edu	37	chr18	21140392	21140392	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacctcatccacagactcGtcacagcctttggtggcatt	8	11	9	13	1	2	2	2	1	0	1	4	2	3	2	3	2	1	1	3	2	0	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr18:21140392G>A	uc002kum.3	-	6	958	c.684C>T	c.(682-684)GAC>GAT	p.D228D	NPC1_uc010xaz.1_Silent_p.D12D|NPC1_uc010xba.1_Silent_p.D73D	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	228					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCACAGACTCGTCACAGCCTT	0.512													18	19					0	0	0	0	A	21140392	A	A	21140392	2	1	299	1	0	0	0	0	0	0	0	1	10624	1136	40	1		1	NPC1	18	21140392	Silent	SNP	G	TCGA-HD-7754-01A-11D-2078-08		21140392	56936856	61	55273											
CDC37	11140	broad.mit.edu	37	chr19	10505957	10505957	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caggtaattggctgtctcctCgcacaccaggtggacgttgt	7	11	12	11	2	1	0	0	0	1	0	3	1	1	1	2	4	0	4	2	4	1	3			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr19:10505957C>T	uc002mof.1	-	4	666	c.550G>A	c.(550-552)GAG>AAG	p.E184K	CDC37_uc002moe.1_Missense_Mutation_p.E139K|CDC37_uc010dxf.1_Missense_Mutation_p.E21K|CDC37_uc002mog.1_Missense_Mutation_p.E184K|CDC37_uc002moh.2_Missense_Mutation_p.E184K	NM_007065	NP_008996	Q16543	CDC37_HUMAN	cell division cycle 37 protein	184					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		GCTGTCTCCTCGCACACCAGG	0.587													49	84					0	0	0	0	T	10505957	T	T	10505957	3	4	299	1	0	0	0	0	1	0	0	0	3083	893	31	1	606	1	CDC37	19	10505957	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08		10505957	48623026	62	55274											
HAPLN4	404037	broad.mit.edu	37	chr19	19369528	19369528	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccagcccgcgttgcaccaGtccaggccgtcgcgccaggc	7	4	12	18	5	0	0	0	0	0	0	2	0	1	0	6	2	3	2	6	2	1	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr19:19369528G>T	uc002nmb.2	-	4	676	c.621C>A	c.(619-621)GAC>GAA	p.D207E	HAPLN4_uc002nmc.2_Missense_Mutation_p.D207E	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	207	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			CGTTGCACCAGTCCAGGCCGT	0.731													4	7					0.00024832	0.00025608	1	0	T	19369528	T	T	19369528	3	4	299	1	0	0	0	0	1	0	0	0	6996	1020	36	4	595	4	HAPLN4	19	19369528	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	8863571	19369528	39759455	63	55275											
TSHZ3	57616	broad.mit.edu	37	chr19	31770448	31770448	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgctttcaaagtcagccattCggtcactggtctcactgatg	8	12	9	12	2	4	1	4	1	1	0	6	1	4	1	1	2	1	1	1	2	1	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr19:31770448C>T	uc002nsy.3	-	2	316	c.251G>A	c.(250-252)CGA>CAA	p.R84Q		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	84					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GTCAGCCATTCGGTCACTGGT	0.587													10	21					0	0	0	0	T	31770448	T	T	31770448	3	4	299	1	0	0	0	0	1	0	0	0	16692	884	31	1	2998	1	TSHZ3	19	31770448	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	12400920	31770448	27358535	64	55276											
SLC23A2	9962	broad.mit.edu	37	chr20	4842675	4842675	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tccaagcacaaagaggttccGggaagaatttaaatcaatga	17	8	9	7	1	1	3	1	1	0	2	3	4	3	4	2	2	1	2	2	2	7	3			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr20:4842675G>A	uc002wlg.1	-	15	1918	c.1543C>T	c.(1543-1545)CGG>TGG	p.R515W	SLC23A2_uc010zqr.1_Missense_Mutation_p.R400W|SLC23A2_uc002wlh.1_Missense_Mutation_p.R515W	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	515	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						AAGAGGTTCCGGGAAGAATTT	0.473													14	20					0	0	0	0	A	4842675	A	A	4842675	3	1	299	1	0	0	0	0	1	0	0	0	14527	1115	39	1	421	1	SLC23A2	20	4842675	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08		4842675	58182845	65	55277											
CSRP2BP	57325	broad.mit.edu	37	chr20	18165392	18165392	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgttcgtccaccctgaatggAgaagagcagggattgcaact	11	9	12	9	1	0	3	0	1	0	2	2	5	1	4	2	2	3	3	2	2	3	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr20:18165392A>C	uc002wqj.2	+	10	2753	c.2131A>C	c.(2131-2133)AGA>CGA	p.R711R	CSRP2BP_uc002wqk.2_Silent_p.R583R|CSRP2BP_uc010zru.1_Silent_p.R582R	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	711	N-acetyltransferase.				histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						CCCTGAATGGAGAAGAGCAGG	0.393													22	52					0	0	0	0	C	18165392	C	C	18165392	2	2	299	1	0	0	0	0	0	0	0	1	3985	296	11	5		5	CSRP2BP	20	18165392	Silent	SNP	A	TCGA-HD-7754-01A-11D-2078-08	13322717	18165392	44860128	66	55278											
EYA2	2139	broad.mit.edu	37	chr20	45812032	45812032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtggaagaggagcaaggagCgaaaaaggtacttcttccac	14	7	13	7	1	1	1	0	0	1	1	2	5	2	4	1	4	3	2	1	4	5	3			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr20:45812032C>T	uc002xsm.2	+	15	1903	c.1529C>T	c.(1528-1530)GCG>GTG	p.A510V	EYA2_uc010ghp.2_Missense_Mutation_p.A431V|EYA2_uc002xsn.2_Missense_Mutation_p.A515V|EYA2_uc002xso.2_Missense_Mutation_p.A510V|EYA2_uc002xsp.2_Missense_Mutation_p.A510V|EYA2_uc002xsq.2_Missense_Mutation_p.A480V	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	510					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				gagcaaggagcgaaaaaggta	0.403													22	24					0	0	0	0	T	45812032	T	T	45812032	3	4	299	1	0	0	0	0	1	0	0	0	5354	768	27	1	1583	1	EYA2	20	45812032	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	27646640	45812032	17213488	67	55279											
ARFGEF2	10564	broad.mit.edu	37	chr20	47567892	47567892	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tacgggcacatcactggcaaCgcccctgacagtggagcccc	9	5	11	16	2	1	1	1	1	0	0	1	2	1	2	4	3	3	2	4	3	2	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr20:47567892C>T	uc002xtx.3	+	4	461	c.309C>T	c.(307-309)AAC>AAT	p.N103N		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	103					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TCACTGGCAACGCCCCTGACA	0.517													11	25					0	0	0	0	T	47567892	T	T	47567892	2	4	299	1	0	0	0	0	0	0	0	1	853	535	19	1		1	ARFGEF2	20	47567892	Silent	SNP	C	TCGA-HD-7754-01A-11D-2078-08	1755860	47567892	15457628	68	55280											
BCAS1	8537	broad.mit.edu	37	chr20	52570172	52570172	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggagccctctttacccttCtgtggtgctcctgttggttc	3	15	11	12	0	2	0	0	0	2	0	4	2	3	1	3	3	3	3	3	3	1	5			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr20:52570172C>T	uc002xws.2	-	11	1817	c.1479G>A	c.(1477-1479)CAG>CAA	p.Q493Q	BCAS1_uc010zza.1_Silent_p.Q159Q|BCAS1_uc010zzb.1_Silent_p.Q419Q|BCAS1_uc010gim.2_Silent_p.Q349Q|BCAS1_uc002xwt.2_Silent_p.Q479Q|BCAS1_uc010gil.1_Silent_p.Q415Q	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	493						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CTTTACCCTTCTGTGGTGCTC	0.493													15	40					0	0	0	0	T	52570172	T	T	52570172	2	4	299	1	0	0	0	0	0	0	0	1	1352	912	32	2		2	BCAS1	20	52570172	Silent	SNP	C	TCGA-HD-7754-01A-11D-2078-08	5002280	52570172	10455348	69	55281											
DYRK1A	1859	broad.mit.edu	37	chr21	38858909	38858909	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catgacactgaaatgaaataCtacataggtaaacaaacagg	20	7	7	7	0	0	3	0	3	0	0	0	3	0	3	0	2	4	1	0	2	8	4			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr21:38858909C>T	uc002ywk.2	+	5	732	c.657C>T	c.(655-657)TAC>TAT	p.Y219Y	DYRK1A_uc002ywh.1_Silent_p.Y181Y|DYRK1A_uc002ywi.2_Silent_p.Y219Y|DYRK1A_uc002ywj.2_Silent_p.Y210Y|DYRK1A_uc002ywl.2_Silent_p.Y219Y|DYRK1A_uc002ywm.2_Silent_p.Y219Y|DYRK1A_uc011aei.1_5'Flank	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	219	Protein kinase.				nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4						AAATGAAATACTACATAGGTA	0.348													13	18					0	0	0	0	T	38858909	T	T	38858909	2	4	299	1	0	0	0	0	0	0	0	1	4876	576	20	4		4	DYRK1A	21	38858909	Silent	SNP	C	TCGA-HD-7754-01A-11D-2078-08		38858909	9270986	70	55282											
DIP2A	23181	broad.mit.edu	37	chr21	47916967	47916967	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggaagatgcctatgccttCgaagagacgttctgtccttg	9	11	12	9	2	1	2	0	0	1	2	3	6	2	3	3	1	2	1	3	1	3	4			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr21:47916967C>T	uc002zjo.2	+	4	533	c.350C>T	c.(349-351)TCG>TTG	p.S117L	DIP2A_uc011afy.1_Missense_Mutation_p.S53L|DIP2A_uc011afz.1_Missense_Mutation_p.S117L|DIP2A_uc002zjl.2_Missense_Mutation_p.S117L|DIP2A_uc002zjm.2_Missense_Mutation_p.S117L|DIP2A_uc010gql.2_Missense_Mutation_p.S117L|DIP2A_uc002zjn.2_Missense_Mutation_p.S117L	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	117					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CCTATGCCTTCGAAGAGACGT	0.438													8	13					0	0	0	0	T	47916967	T	T	47916967	3	4	299	1	0	0	0	0	1	0	0	0	4549	893	31	1	364	1	DIP2A	21	47916967	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	9058058	47916967	212928	71	55283											
CRYBA4	1413	broad.mit.edu	37	chr22	27021582	27021582	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctccttccggcctgcggcctGtgctgtaagttctaccactg	4	12	10	15	2	1	0	0	0	1	0	3	0	3	0	5	2	3	3	5	2	2	4			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr22:27021582G>T	uc003acz.3	+	4	331	c.296G>T	c.(295-297)TGT>TTT	p.C99F		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	99	Connecting peptide.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						CCTGCGGCCTGTGCTGTAAGT	0.502													21	65					2.27525e-19	2.5309e-19	1	0	T	27021582	T	T	27021582	3	4	299	1	0	0	0	0	1	0	0	0	3924	1377	48	4	306	4	CRYBA4	22	27021582	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08		27021582	24282984	72	55284											
RBX1	9978	broad.mit.edu	37	chr22	41363843	41363843	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	catctctcgctggctcaaaaCacgacaggtgtgtccattgg	9	10	10	12	2	2	0	1	0	1	0	5	1	3	0	1	3	1	2	1	3	2	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr22:41363843C>T	uc003azk.2	+	4	287	c.269C>T	c.(268-270)ACA>ATA	p.T90I	XPNPEP3_uc011aoy.1_RNA	NM_014248	NP_055063	P62877	RBX1_HUMAN	ring-box 1	90	RING-type.				DNA repair|interspecies interaction between organisms|protein neddylation|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	Cul3-RING ubiquitin ligase complex|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytosol|nucleus|SCF ubiquitin ligase complex	NEDD8 ligase activity|protein binding|zinc ion binding			skin(1)	1						TGGCTCAAAACACGACAGGTG	0.438													15	36					0	0	0	0	T	41363843	T	T	41363843	3	4	299	1	0	0	0	0	1	0	0	0	13230	478	17	4	283	4	RBX1	22	41363843	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	14342261	41363843	9940723	73	55285											
PLXNB2	23654	broad.mit.edu	37	chr22	50719042	50719042	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgccaccgtcagcagggacgCgaagtagaccttggcgcggg	8	4	16	13	6	1	1	1	0	0	1	1	3	1	2	3	3	1	2	3	3	2	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr22:50719042C>T	uc003bkv.3	-	25	4157	c.4051G>A	c.(4051-4053)GCG>ACG	p.A1351T	PLXNB2_uc003bkt.1_Missense_Mutation_p.A143T|PLXNB2_uc003bku.1_Missense_Mutation_p.A336T	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1351	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGCAGGGACGCGAAGTAGACC	0.637													7	37					0	0	0	0	T	50719042	T	T	50719042	3	4	299	1	0	0	0	0	1	0	0	0	12179	768	27	1	1517	1	PLXNB2	22	50719042	Missense_Mutation	SNP	C	TCGA-HD-7754-01A-11D-2078-08	9355199	50719042	585524	74	55286											
NCAPH2	29781	broad.mit.edu	37	chr22	50960982	50960982	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cccgagggagcagaccccagGgaagccgctgaccttggtag	9	4	15	13	2	0	2	0	1	0	1	0	5	0	4	5	3	2	3	5	3	2	2			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chr22:50960982G>T	uc003blr.3	+	16	1481	c.1359G>T	c.(1357-1359)AGG>AGT	p.R453S	NCAPH2_uc003blv.2_Missense_Mutation_p.R453S|NCAPH2_uc010hbb.2_Intron|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Missense_Mutation_p.R454S|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	453					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CAGACCCCAGGGAAGCCGCTG	0.652													16	30					5.3912e-06	5.67797e-06	1	0	T	50960982	T	T	50960982	3	4	299	1	0	0	0	0	1	0	0	0	10264	1223	43	4	1463	4	NCAPH2	22	50960982	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08	241940	50960982	343584	75	55287											
ATRX	546	broad.mit.edu	37	chrX	76890120	76890120	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggcccatacagtgggcaaGaatgcatcctgaacctggag	13	6	12	10	0	0	2	0	1	0	1	1	3	1	3	3	3	3	2	3	3	5	1			TCGA-HD-7754-01A-11D-2078-08	TCGA-HD-7754-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	233ecdc4-0b42-4533-8908-64ac7d3ac33b	6dc263f5-fd86-46d4-a8db-2d147aa1c727	g.chrX:76890120G>A	uc004ecp.3	-	17	5006	c.4774C>T	c.(4774-4776)CTT>TTT	p.L1592F	ATRX_uc004ecq.3_Missense_Mutation_p.L1554F|ATRX_uc004eco.3_Missense_Mutation_p.L1377F	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1592	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CAGTGGGCAAGAATGCATCCT	0.343			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						52	21					0	0	0	0	A	76890120	A	A	76890120	3	1	299	1	0	0	0	0	1	0	0	0	1210	942	33	2	2780	2	ATRX	23	76890120	Missense_Mutation	SNP	G	TCGA-HD-7754-01A-11D-2078-08		76890120	78380440	76	55288											
FBXO2	26232	broad.mit.edu	37	chr1	11708856	11708856	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcggacgaagcggacgccCggcccgtagtcggtgaaggt	9	4	17	11	7	0	1	0	1	0	0	1	4	0	3	2	5	2	1	2	5	4	1	rs141266599	byFrequency	TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr1:11708856C>T	uc001asj.2	-	6	1128	c.786G>A	c.(784-786)CCG>CCA	p.P262P	FBXO2_uc009vna.2_Silent_p.P265P	NM_012168	NP_036300	Q9UK22	FBX2_HUMAN	F-box only protein 2	262	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity				0	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		AGCGGACGCCCGGCCCGTAGT	0.672													8	93					0	0	0	0	T	11708856	T	T	11708856	2	4	300	1	0	0	0	0	0	0	0	1	5764	639	23	1		1	FBXO2	1	11708856	Silent	SNP	C	TCGA-HD-7831-01A-11D-2129-08		11708856	237541765	1	55289											
IQGAP3	128239	broad.mit.edu	37	chr1	156509200	156509200	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagtgctgtcttgaacagctGgagcaggagataggcctctc	9	9	14	9	0	2	2	0	1	2	1	3	5	2	3	1	3	4	3	1	3	2	2			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr1:156509200G>A	uc001fpf.2	-	25	3097	c.3022C>T	c.(3022-3024)CAG>TAG	p.Q1008*		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1008	Ras-GAP.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTGAACAGCTGGAGCAGGAGA	0.517													7	19					0	0	0	0	A	156509200	A	A	156509200	4	1	300	1	0	0	0	0	0	1	0	0	7855	1357	47	4	1929	4	IQGAP3	1	156509200	Nonsense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08	144800344	156509200	92741421	2	55290											
IQGAP3	128239	broad.mit.edu	37	chr1	156513967	156513967	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctggaagtagtgcagacGcctcaggtattgcctccgag	8	10	12	11	2	2	1	1	0	1	1	3	3	3	2	3	2	2	3	3	2	3	4			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr1:156513967G>A	uc001fpf.2	-	21	2512	c.2437C>T	c.(2437-2439)CGT>TGT	p.R813C		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	813	IQ 3.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TAGTGCAGACGCCTCAGGTAT	0.592													16	89					0	0	0	0	A	156513967	A	A	156513967	3	1	300	1	0	0	0	0	1	0	0	0	7855	1087	38	1	2530	1	IQGAP3	1	156513967	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08	4767	156513967	92736654	3	55291											
RPIA	22934	broad.mit.edu	37	chr2	89035244	89035244	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctagtcgcttcatcgtgatcGctgatttcaggtacagtttc	7	15	9	10	3	2	2	2	2	0	0	6	2	2	2	0	1	1	4	0	1	2	5			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr2:89035244G>A	uc002ste.2	+	6	627	c.586G>A	c.(586-588)GCT>ACT	p.A196T		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	196					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				CATCGTGATCGCTGATTTCAG	0.493													35	124					0	0	0	0	A	89035244	A	A	89035244	3	1	300	1	0	0	0	0	1	0	0	0	13618	1087	38	1	608	1	RPIA	2	89035244	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08		89035244	154164129	4	55292											
IL1RL1	9173	broad.mit.edu	37	chr2	102968039	102968039	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	aacatacgaaagagcaggcgGcacattttcatcctgacccc	13	7	8	13	2	1	2	1	1	0	1	2	3	2	2	3	2	3	2	3	2	3	3	rs111942110	byFrequency	TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr2:102968039G>A	uc002tbu.1	+	11	1600	c.1329G>A	c.(1327-1329)CGG>CGA	p.R443R	IL18R1_uc002tbw.3_Intron	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	443	TIR.|Cytoplasmic (Potential).				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						AGAGCAGGCGGCACATTTTCA	0.458													4	54					0	0	0	0	A	102968039	A	A	102968039	2	1	300	1	0	0	0	0	0	0	0	1	7702	1190	42	4		4	IL1RL1	2	102968039	Silent	SNP	G	TCGA-HD-7831-01A-11D-2129-08	13932795	102968039	140231334	5	55293											
TUBA3E	112714	broad.mit.edu	37	chr2	130949467	130949469	+	In_Frame_Del	DEL	CTT	-	-																															acgcccacctcttcacaatcCttctctagagctgccaggtc																										TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr2:130949467_130949469delCTT	uc002tqv.2	-	5	1389_1391	c.1288_1290delAAG	c.(1288-1290)AAGdel	p.K430del		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	430					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					CTTCACAATCCTTCTCTAGAGCT	0.591													---	---	---								-	130949469	-	-	130949467	7	5	300	1	0	1	0	1	0	0	0	0	16816	680	24	0	66	0	TUBA3E	2	130949467	In_Frame_Del	DEL	CTT	TCGA-HD-7831-01A-11D-2129-08	27981428	130949467	112249906	6	55294											
PTH1R	5745	broad.mit.edu	37	chr3	46944059	46944059	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcatgcccctctttggcGtccactacattgtcttcatg	5	15	7	14	1	4	0	2	0	2	0	5	0	5	0	3	1	3	1	3	1	1	4			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr3:46944059G>A	uc003cqm.2	+	14	1458	c.1255G>A	c.(1255-1257)GTC>ATC	p.V419I	PTH1R_uc003cqn.2_Missense_Mutation_p.V419I	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	419	Helical; Name=6; (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						CCTCTTTGGCGTCCACTACAT	0.567									Ollier_disease_/_Maffuci_syndrome				4	8					0	0	0	0	A	46944059	A	A	46944059	3	1	300	1	0	0	0	0	1	0	0	0	12821	1145	40	1	1301	1	PTH1R	3	46944059	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08		46944059	151078371	7	55295											
TOPBP1	11073	broad.mit.edu	37	chr3	133362159	133362159	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tcctgtcattactggaactgGtgtgaagagaggattcgact	10	12	12	7	1	1	2	1	1	0	1	3	6	2	4	1	3	2	0	1	3	3	2			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr3:133362159G>C	uc003eps.2	-	12	2038	c.1906C>G	c.(1906-1908)CCA>GCA	p.P636A		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	636					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding	p.E636Q(1)		ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						ACTGGAACTGGTGTGAAGAGA	0.368								Other_conserved_DNA_damage_response_genes					14	47					0	0	0	0	C	133362159	C	C	133362159	3	2	300	1	0	0	0	0	1	0	0	0	16436	1261	44	4	2730	4	TOPBP1	3	133362159	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08	86418100	133362159	64660271	8	55296											
PLCH1	23007	broad.mit.edu	37	chr3	155215156	155215156	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggagtttgtgtacacaaccAaatcagagagttctcggcag	12	9	11	9	2	2	1	1	0	1	1	3	3	2	2	1	2	2	4	1	2	3	3			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr3:155215156A>T	uc011bok.1	-	14	2088	c.1811T>A	c.(1810-1812)TTG>TAG	p.L604*	PLCH1_uc011boj.1_Nonsense_Mutation_p.L604*|PLCH1_uc011bol.1_Nonsense_Mutation_p.L586*	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	604	PI-PLC Y-box.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GTACACAACCAAATCAGAGAG	0.463													13	85					0	0	0	0	T	155215156	T	T	155215156	4	4	300	1	0	0	0	0	0	1	0	0	12092	131	5	5	3325	5	PLCH1	3	155215156	Nonsense_Mutation	SNP	A	TCGA-HD-7831-01A-11D-2129-08	21852997	155215156	42807274	9	55297											
PIGG	54872	broad.mit.edu	37	chr4	515515	515515	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctgagctggaagtcccaCtgtcatctcctgggttttct	6	13	11	11	0	3	1	1	1	2	0	5	2	4	2	2	3	1	3	2	3	1	2			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr4:515515C>T	uc003gak.3	+	8	1535	c.1399C>T	c.(1399-1401)CTG>TTG	p.L467L	PIGG_uc003gaj.3_Silent_p.L459L|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Silent_p.L334L|PIGG_uc003gal.3_Silent_p.L378L|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Silent_p.H329H|PIGG_uc003gam.2_3'UTR|PIGG_uc003gan.2_Silent_p.L378L	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	467					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						GGAAGTCCCACTGTCATCTCC	0.532													17	51					0	0	0	0	T	515515	T	T	515515	2	4	300	1	0	0	0	0	0	0	0	1	11943	564	20	4		4	PIGG	4	515515	Silent	SNP	C	TCGA-HD-7831-01A-11D-2129-08		515515	190638761	10	55298											
FAM193A	8603	broad.mit.edu	37	chr4	2659530	2659530	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttttacatccccttactagAtgacaatgaaaaccaagcag	15	11	5	10	0	0	3	0	2	0	1	1	3	1	3	3	0	4	1	3	0	7	5			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr4:2659530A>G	uc010icl.2	+	6	790	c.439A>G	c.(439-441)ATG>GTG	p.M147V	FAM193A_uc010ick.2_Missense_Mutation_p.M347V|FAM193A_uc003gfd.2_Missense_Mutation_p.M147V|FAM193A_uc011bvm.1_Missense_Mutation_p.M171V|FAM193A_uc011bvn.1_Missense_Mutation_p.M147V|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.M1V	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	147										ovary(3)	3						CCCTTACTAGATGACAATGAA	0.333													33	147					0	0	0	0	G	2659530	G	G	2659530	3	3	300	1	0	0	0	0	1	0	0	0	5552	347	12	5	453	5	FAM193A	4	2659530	Missense_Mutation	SNP	A	TCGA-HD-7831-01A-11D-2129-08	2144015	2659530	188494746	11	55299											
SLC12A7	10723	broad.mit.edu	37	chr5	1094337	1094337	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ctcgacattgttgaggaatgGgctgttttctcttggatttc	6	17	11	7	1	1	1	0	1	1	0	4	4	1	3	0	3	0	3	0	3	1	6			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr5:1094337G>C	uc003jbu.2	-	2	217	c.151C>G	c.(151-153)CCA>GCA	p.P51A		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	51	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	TTGAGGAATGGGCTGTTTTCT	0.423													13	116					0	0	0	0	C	1094337	C	C	1094337	3	2	300	1	0	0	0	0	1	0	0	0	14453	1232	43	4	3192	4	SLC12A7	5	1094337	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08		1094337	179820923	12	55300											
SPEF2	79925	broad.mit.edu	37	chr5	35759820	35759820	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaattctgaaagccagcttAggtaaggcaggctattatat	14	11	9	7	0	1	1	0	1	1	0	1	1	1	1	1	3	2	4	1	3	7	6			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr5:35759820A>G	uc003jjo.2	+	25	3730	c.3619A>G	c.(3619-3621)AGA>GGA	p.R1207G	SPEF2_uc003jjp.1_Missense_Mutation_p.R693G	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1207					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAGCCAGCTTAGGTAAGGCAG	0.318													29	115					0	0	0	0	G	35759820	G	G	35759820	3	3	300	1	0	0	0	0	1	0	0	0	15101	434	15	5	3738	5	SPEF2	5	35759820	Missense_Mutation	SNP	A	TCGA-HD-7831-01A-11D-2129-08	34665483	35759820	145155440	13	55301											
RASA1	5921	broad.mit.edu	37	chr5	86672729	86672740	+	In_Frame_Del	DEL	ATGCTTTATCAC	-	-																															aaaggaacttcatgtagtctAtgctttatcacatgtatgtg																										TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr5:86672729_86672740delATGCTTTATCAC	uc003kiw.2	+	17	2334_2345	c.2216_2227delATGCTTTATCAC	c.(2215-2229)TATGCTTTATCACAT>TAT	p.ALSH740del	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_In_Frame_Del_p.ALSH563del|RASA1_uc011ctv.1_In_Frame_Del_p.ALSH573del|RASA1_uc011ctw.1_In_Frame_Del_p.ALSH574del|RASA1_uc010jaw.2_In_Frame_Del_p.ALSH562del	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	740_743					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		CATGTAGTCTATGCTTTATCACATGTATGTGG	0.368													---	---	---								-	86672740	-	-	86672729	7	5	300	1	0	1	0	1	0	0	0	0	13125	449	16	0	2294	0	RASA1	5	86672729	In_Frame_Del	DEL	ATGCTTTATCAC	TCGA-HD-7831-01A-11D-2129-08	50912909	86672729	94242531	14	55302											
CDO1	1036	broad.mit.edu	37	chr5	115151945	115151945	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtactggtcgaacttggcGtacattgcccactcggtggg	6	11	13	11	3	0	0	0	0	0	0	2	1	0	0	1	4	4	2	1	4	3	4			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr5:115151945G>A	uc003krg.2	-	1	461	c.150C>T	c.(148-150)TAC>TAT	p.Y50Y		NM_001801	NP_001792	Q16878	CDO1_HUMAN	cysteine dioxygenase	50					inflammatory response|sulfur amino acid biosynthetic process|taurine biosynthetic process	cytosol	cysteine dioxygenase activity			large_intestine(1)|skin(1)	2		all_cancers(142;0.0046)|all_epithelial(76;0.000161)|Prostate(80;0.0132)|Ovarian(225;0.0776)		OV - Ovarian serous cystadenocarcinoma(64;7.8e-08)|Epithelial(69;7.32e-07)|all cancers(49;3.24e-05)	L-Cysteine(DB00151)|NADH(DB00157)	CGAACTTGGCGTACATTGCCC	0.632													23	78					0	0	0	0	A	115151945	A	A	115151945	2	1	300	1	0	0	0	0	0	0	0	1	3184	1140	40	1		1	CDO1	5	115151945	Silent	SNP	G	TCGA-HD-7831-01A-11D-2129-08	28479216	115151945	65763315	15	55303											
SYNE1	23345	broad.mit.edu	37	chr6	152557366	152557366	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctgagcagctgatggataTcagaagtcgtttcccatcat	11	12	9	9	1	3	3	2	2	1	1	5	4	4	4	1	1	2	3	1	1	2	2			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr6:152557366T>A	uc010kiw.2	-	110	20874	c.20272A>T	c.(20272-20274)ATA>TTA	p.I6758L	SYNE1_uc010kiv.2_Missense_Mutation_p.I1282L|SYNE1_uc003qos.3_Missense_Mutation_p.I1282L|SYNE1_uc003qot.3_Missense_Mutation_p.I6687L|SYNE1_uc003qou.3_Missense_Mutation_p.I6758L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6758	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGATGGATATCAGAAGTCGT	0.343										HNSCC(10;0.0054)			11	64					0	0	0	0	A	152557366	A	A	152557366	3	1	300	1	0	0	0	0	1	0	0	0	15511	1435	50	5	6342	5	SYNE1	6	152557366	Missense_Mutation	SNP	T	TCGA-HD-7831-01A-11D-2129-08		152557366	18557701	16	55304											
RPS6KA2	6196	broad.mit.edu	37	chr6	166918090	166918090	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaacttgacatcctcctccGtgaacatgacctagtaagaa	14	9	7	11	1	0	5	0	3	0	2	3	5	3	5	4	0	2	1	4	0	5	3			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr6:166918090G>A	uc003qvb.1	-	6	689	c.470C>T	c.(469-471)ACG>ATG	p.T157M	RPS6KA2_uc011ego.1_Missense_Mutation_p.T68M|RPS6KA2_uc010kkl.1_Missense_Mutation_p.T68M|RPS6KA2_uc003qvc.1_Missense_Mutation_p.T165M|RPS6KA2_uc003qvd.1_Missense_Mutation_p.T182M	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	157	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		ATCCTCCTCCGTGAACATGAC	0.413													15	68					0	0	0	0	A	166918090	A	A	166918090	3	1	300	1	0	0	0	0	1	0	0	0	13716	1145	40	1	1795	1	RPS6KA2	6	166918090	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08	14360724	166918090	4196977	17	55305											
IQCE	23288	broad.mit.edu	37	chr7	2632713	2632713	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctggagaaggagctggagtgCgcgagggagggcgaggagga	10	3	23	5	3	0	1	0	0	0	1	0	9	0	6	0	7	2	1	0	7	1	0			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr7:2632713C>T	uc003smo.3	+	15	1486	c.1302C>T	c.(1300-1302)TGC>TGT	p.C434C	IQCE_uc010ksm.1_Silent_p.C434C|IQCE_uc003sml.1_Silent_p.C434C|IQCE_uc011jvy.1_Silent_p.C418C|IQCE_uc011jvz.1_Silent_p.C369C|IQCE_uc003smk.3_Silent_p.C418C|IQCE_uc003smn.3_Silent_p.C369C	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	434	Potential.										0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		agctggagtgcgcgagggagg	0.418													16	84					0	0	0	0	T	2632713	T	T	2632713	2	4	300	1	0	0	0	0	0	0	0	1	7845	776	27	1		1	IQCE	7	2632713	Silent	SNP	C	TCGA-HD-7831-01A-11D-2129-08		2632713	156505950	18	55306											
SP4	6671	broad.mit.edu	37	chr7	21516774	21516774	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgtagcagttggaggaattGctaatgccacgataggtgct	10	11	13	7	1	0	0	0	0	0	0	0	3	0	2	1	3	4	5	1	3	4	5			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr7:21516774G>T	uc003sva.2	+	4	1937	c.1756G>T	c.(1756-1758)GCT>TCT	p.A586S	SP4_uc003svb.2_Missense_Mutation_p.A273S	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	586					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						TGGAGGAATTGCTAATGCCAC	0.453													10	38					3.07112e-06	3.35031e-06	1	0	T	21516774	T	T	21516774	3	4	300	1	0	0	0	0	1	0	0	0	15030	1319	46	4	1770	4	SP4	7	21516774	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08	18884061	21516774	137621889	19	55307											
ABCB1	5243	broad.mit.edu	37	chr7	87178771	87178771	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaccagggcacgtgcaatggCgatcctctgcttctgcccac	8	8	10	15	2	2	0	0	0	2	0	3	1	3	0	3	2	4	3	3	2	2	1			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr7:87178771C>T	uc003uiz.1	-	15	2036	c.1618G>A	c.(1618-1620)GCC>ACC	p.A540T	ABCB1_uc011khc.1_Missense_Mutation_p.A476T	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	540	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CGTGCAATGGCGATCCTCTGC	0.547													8	184					0	0	0	0	T	87178771	T	T	87178771	3	4	300	1	0	0	0	0	1	0	0	0	40	768	27	1	2284	1	ABCB1	7	87178771	Missense_Mutation	SNP	C	TCGA-HD-7831-01A-11D-2129-08	65661997	87178771	71959892	20	55308											
SLC26A4	5172	broad.mit.edu	37	chr7	107314736	107314736	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgatagacactgcagctagAgatacagctagagtcctgat	14	9	10	8	0	0	5	0	2	0	3	1	6	1	5	1	0	4	3	1	0	4	4			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr7:107314736A>G	uc003vep.2	+	5	767	c.543A>G	c.(541-543)AGA>AGG	p.R181R		NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	181	Extracellular (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						CTGCAGCTAGAGATACAGCTA	0.413									Pendred_syndrome				11	48					0	0	0	0	G	107314736	G	G	107314736	2	3	300	1	0	0	0	0	0	0	0	1	14583	301	11	5		5	SLC26A4	7	107314736	Silent	SNP	A	TCGA-HD-7831-01A-11D-2129-08	20135965	107314736	51823927	21	55309											
UBR5	51366	broad.mit.edu	37	chr8	103293651	103293651	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	actggaagaacatcagaatgCtcatcattatgagaccgcat	15	9	8	9	1	3	3	3	1	0	3	3	5	3	4	1	1	2	2	1	1	4	1			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr8:103293651C>T	uc003ykr.1	-	41	5826	c.5793G>A	c.(5791-5793)GAG>GAA	p.E1931E	UBR5_uc003yks.1_Silent_p.E1931E	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1931					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CATCAGAATGCTCATCATTAT	0.423													19	111					0	0	0	0	T	103293651	T	T	103293651	2	4	300	1	0	0	0	0	0	0	0	1	16973	796	28	4		4	UBR5	8	103293651	Silent	SNP	C	TCGA-HD-7831-01A-11D-2129-08		103293651	43070371	22	55310											
SEMA4D	10507	broad.mit.edu	37	chr9	91994380	91994380	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttctgacaagttgaagatgaGcaagttttttctgcccataa	12	14	8	7	0	2	4	0	3	2	1	2	4	2	4	1	0	2	3	1	0	4	6			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr9:91994380G>A	uc004aqo.1	-	18	2400	c.1828C>T	c.(1828-1830)CTC>TTC	p.L610F	SEMA4D_uc011ltm.1_Intron|SEMA4D_uc011ltn.1_Intron|SEMA4D_uc011lto.1_Intron|SEMA4D_uc004aqp.1_Missense_Mutation_p.L608F	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	610	Ig-like C2-type.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						TTGAAGATGAGCAAGTTTTTT	0.517													20	300					0	0	0	0	A	91994380	A	A	91994380	3	1	300	1	0	0	0	0	1	0	0	0	14099	971	34	4	1334	4	SEMA4D	9	91994380	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08		91994380	49219051	23	55311											
LHX2	9355	broad.mit.edu	37	chr9	126777641	126777641	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aaccatgccgacgtggcagcGgcggccgctgcagccgcggc	6	3	16	16	7	0	0	0	0	0	0	0	1	0	0	4	4	5	3	4	4	1	0			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr9:126777641G>A	uc004boe.1	+	3	1303	c.564G>A	c.(562-564)GCG>GCA	p.A188A	LHX2_uc010mwi.1_Silent_p.A196A	NM_004789	NP_004780	P50458	LHX2_HUMAN	LIM homeobox protein 2	188	Poly-Ala.					nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACGTGGCAGCGGCGGCCGCTG	0.677													3	28					0	0	0	0	A	126777641	A	A	126777641	2	1	300	1	0	0	0	0	0	0	0	1	8812	1103	39	1		1	LHX2	9	126777641	Silent	SNP	G	TCGA-HD-7831-01A-11D-2129-08	34783261	126777641	14435790	24	55312											
MED22	6837	broad.mit.edu	37	chr9	136211174	136211174	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaccagcttcatcagggaCtcgccggctcggacctgtgg	7	7	13	14	3	2	0	2	0	0	0	4	3	2	2	3	4	1	2	3	4	0	1			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr9:136211174C>A	uc004cdc.2	-	4	453	c.219G>T	c.(217-219)GAG>GAT	p.E73D	MED22_uc004cdd.2_Missense_Mutation_p.E73D	NM_133640	NP_598395	Q15528	MED22_HUMAN	mediator complex subunit 22 isoform b	73					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|mediator complex|soluble fraction	protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.14e-06)|Epithelial(140;8.2e-06)|all cancers(34;6.94e-05)		TCATCAGGGACTCGCCGGCTC	0.507													4	47					1.23904e-05	1.32754e-05	1	0	A	136211174	A	A	136211174	3	1	300	1	0	0	0	0	1	0	0	0	9493	564	20	4	401	4	MED22	9	136211174	Missense_Mutation	SNP	C	TCGA-HD-7831-01A-11D-2129-08	9433533	136211174	5002257	25	55313											
C9orf139	401563	broad.mit.edu	37	chr9	139929486	139929486	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcaggggctccccctcatctCaccccacccaggcctcctga	6	6	8	21	0	2	1	2	1	1	0	5	1	4	1	7	3	0	2	7	3	0	0			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr9:139929486C>T	uc004ckp.1	+	3	2067	c.553C>T	c.(553-555)CAC>TAC	p.H185Y	FUT7_uc004ckq.2_5'Flank	NM_207511	NP_997394	Q6ZV77	CI139_HUMAN	hypothetical protein LOC401563	185											0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		CCCCTCATCTCACCCCACCCA	0.592													17	56					0	0	0	0	T	139929486	T	T	139929486	3	4	300	1	0	0	0	0	1	0	0	0	2471	826	29	2	559	2	C9orf139	9	139929486	Missense_Mutation	SNP	C	TCGA-HD-7831-01A-11D-2129-08	3718312	139929486	1283945	26	55314											
RSU1	6251	broad.mit.edu	37	chr10	16794565	16794565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgggggcagaacggtgaggcGgttcccctgaatgtggagct	7	8	18	8	2	0	3	0	2	0	1	1	4	1	4	2	6	2	3	2	6	2	1			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr10:16794565G>A	uc001iok.2	-	6	873	c.571C>T	c.(571-573)CGC>TGC	p.R191C	RSU1_uc001iol.2_Missense_Mutation_p.R191C|RSU1_uc001iom.2_Missense_Mutation_p.R138C|RSU1_uc001ion.2_Missense_Mutation_p.R191C	NM_152724	NP_689937	Q15404	RSU1_HUMAN	ras suppressor protein 1 isoform 2	191	LRR 7.				cell junction assembly|signal transduction	cytosol	protein binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(1;7.54e-08)		ACGGTGAGGCGGTTCCCCTGA	0.463													21	84					0	0	0	0	A	16794565	A	A	16794565	3	1	300	1	0	0	0	0	1	0	0	0	13781	1116	39	1	274	1	RSU1	10	16794565	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08		16794565	118740182	27	55315											
OR52J3	119679	broad.mit.edu	37	chr11	5068241	5068241	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttacttacacttcccatggtCtatcttatctaccgcctacc	8	15	3	15	1	3	0	0	0	3	0	4	0	4	0	4	1	4	0	4	1	6	7			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr11:5068241C>G	uc010qyv.1	+	1	486	c.486C>G	c.(484-486)GTC>GTG	p.V162V		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	162	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTCCCATGGTCTATCTTATCT	0.453													16	35					0	0	0	0	G	5068241	G	G	5068241	2	3	300	1	0	0	0	0	0	0	0	1	11176	900	32	2		2	OR52J3	11	5068241	Silent	SNP	C	TCGA-HD-7831-01A-11D-2129-08		5068241	129938275	28	55316											
OR8J1	219477	broad.mit.edu	37	chr11	56128083	56128083	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctggctttgatggcctatGaccgctatgtggctatttgt	5	16	12	8	1	0	2	0	2	0	0	0	2	0	2	2	3	1	4	2	3	3	5			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr11:56128083G>A	uc010rjh.1	+	1	361	c.361G>A	c.(361-363)GAC>AAC	p.D121N		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GATGGCCTATGACCGCTATGT	0.488													10	80					0	0	0	0	A	56128083	A	A	56128083	3	1	300	1	0	0	0	0	1	0	0	0	11295	1290	45	2	363	2	OR8J1	11	56128083	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08	51059842	56128083	78878433	29	55317											
MYO7A	4647	broad.mit.edu	37	chr11	76872053	76872053	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgttcgtgtggattgtggAcaagatcaacgcagcaattt	10	12	12	7	2	1	1	1	0	0	1	2	3	1	3	0	2	2	4	0	2	3	3			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr11:76872053A>G	uc001oyb.2	+	12	1507	c.1235A>G	c.(1234-1236)GAC>GGC	p.D412G	MYO7A_uc010rsl.1_Missense_Mutation_p.D412G|MYO7A_uc010rsm.1_Missense_Mutation_p.D401G|MYO7A_uc001oyc.2_Missense_Mutation_p.D412G	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	412	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						TGGATTGTGGACAAGATCAAC	0.582													4	16					0	0	0	0	G	76872053	G	G	76872053	3	3	300	1	0	0	0	0	1	0	0	0	10135	275	10	5	1277	5	MYO7A	11	76872053	Missense_Mutation	SNP	A	TCGA-HD-7831-01A-11D-2129-08	20743970	76872053	58134463	30	55318											
NARS2	79731	broad.mit.edu	37	chr11	78277240	78277240	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctcaatatagaacccagaaCgttagtcctacacctaaagt	15	9	5	12	1	1	2	1	0	0	2	2	2	2	2	4	0	3	1	4	0	9	5			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr11:78277240C>T	uc001ozi.2	-	4	827	c.451G>A	c.(451-453)GTT>ATT	p.V151I	NARS2_uc010rsq.1_5'UTR	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	151					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	GAACCCAGAACGTTAGTCCTA	0.393													13	63					0	0	0	0	T	78277240	T	T	78277240	3	4	300	1	0	0	0	0	1	0	0	0	10224	536	19	1	1026	1	NARS2	11	78277240	Missense_Mutation	SNP	C	TCGA-HD-7831-01A-11D-2129-08	1405187	78277240	56729276	31	55319											
A2ML1	144568	broad.mit.edu	37	chr12	8994102	8994102	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccctttaccttggagacatcCggttggaatgggacagacgt	9	10	12	10	2	0	2	0	0	0	2	1	5	1	4	3	4	1	1	3	4	2	4			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr12:8994102C>T	uc001quz.3	+	11	1316	c.1218C>T	c.(1216-1218)TCC>TCT	p.S406S	A2ML1_uc001qva.1_5'Flank	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	250						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						TGGAGACATCCGGTTGGAATG	0.473													20	50					0	0	0	0	T	8994102	T	T	8994102	2	4	300	1	0	0	0	0	0	0	0	1	5	639	23	1		1	A2ML1	12	8994102	Silent	SNP	C	TCGA-HD-7831-01A-11D-2129-08		8994102	124857793	32	55320											
CPNE6	9362	broad.mit.edu	37	chr14	24545396	24545396	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcctccaatggggacccgagGagcagccagtccctgcactg	8	5	13	15	1	0	0	0	0	0	0	2	3	2	2	5	3	3	2	5	3	1	0			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr14:24545396G>A	uc001wll.2	+	11	1062	c.963G>A	c.(961-963)AGG>AGA	p.R321R	CPNE6_uc010tnv.1_Silent_p.R376R|CPNE6_uc001wlm.2_Silent_p.R146R|CPNE6_uc001wln.2_5'UTR	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	321	VWFA.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		GGGACCCGAGGAGCAGCCAGT	0.627													11	53					0	0	0	0	A	24545396	A	A	24545396	2	1	300	1	0	0	0	0	0	0	0	1	3831	1165	41	2		2	CPNE6	14	24545396	Silent	SNP	G	TCGA-HD-7831-01A-11D-2129-08		24545396	82804144	33	55321											
TTC7B	145567	broad.mit.edu	37	chr14	91121355	91121356	+	Frame_Shift_Ins	INS	-	GTAC	GTAC																															ccgtcagtggcctgcagactINSgtacgtgagccccagagcta																										TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr14:91121355_91121356insGTAC	uc001xyp.2	-	12	1562_1563	c.1440_1441insGTAC	c.(1438-1443)TACAGTfs	p.Y480fs	TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	480_481	TPR 5.						binding			ovary(2)	2		Melanoma(154;0.222)				GCCTGCAGACTGTACGTGAGCC	0.559													---	---	---								GTAC	91121356	GTAC	GTAC	91121355	7	5	300	1	0	1	1	0	0	0	0	0	16781	1580	55	0	1126	0	TTC7B	14	91121355	Frame_Shift_Ins	INS	-	TCGA-HD-7831-01A-11D-2129-08	66575959	91121355	16228185	34	55322											
DENND4A	10260	broad.mit.edu	37	chr15	65959893	65959893	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggttccaaaaaacaattggaTgatggtccacaaagtctgct	14	10	9	8	0	1	1	0	1	1	0	3	2	3	2	2	3	2	2	2	3	5	2			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr15:65959893T>A	uc002aph.2	-	28	5381	c.5003A>T	c.(5002-5004)CAT>CTT	p.H1668L	DENND4A_uc002api.2_Missense_Mutation_p.H1711L	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1668					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AACAATTGGATGATGGTCCAC	0.388													12	55					0	0	0	0	A	65959893	A	A	65959893	3	1	300	1	0	0	0	0	1	0	0	0	4455	1464	51	5	608	5	DENND4A	15	65959893	Missense_Mutation	SNP	T	TCGA-HD-7831-01A-11D-2129-08		65959893	36571499	35	55323											
CDH13	1012	broad.mit.edu	37	chr16	83813622	83813622	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgctgataaccctggaggaCgtgaatgacaatgccccgtt	10	10	11	10	2	0	3	0	3	0	0	0	5	0	5	3	2	3	2	3	2	3	3	rs151311546	by1000genomes	TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr16:83813622C>T	uc002fgx.2	+	12	1851	c.1731C>T	c.(1729-1731)GAC>GAT	p.D577D	CDH13_uc010vns.1_Silent_p.D624D|CDH13_uc010vnt.1_Silent_p.D323D|CDH13_uc010vnu.1_Silent_p.D538D	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	577	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CCCTGGAGGACGTGAATGACA	0.493													8	29					0	0	0	0	T	83813622	T	T	83813622	2	4	300	1	0	0	0	0	0	0	0	1	3114	535	19	1		1	CDH13	16	83813622	Silent	SNP	C	TCGA-HD-7831-01A-11D-2129-08		83813622	6541131	36	55324											
TP53	7157	broad.mit.edu	37	chr17	7578205	7578206	+	Frame_Shift_Ins	INS	-	T	T																															ctcatagggcaccaccacacINStatgtcgaaaagtgtttctg																										TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr17:7578205_7578206insT	uc002gim.2	-	6	837_838	c.643_644insA	c.(643-645)AGTfs	p.S215fs	TP53_uc002gig.1_Frame_Shift_Ins_p.S215fs|TP53_uc002gih.2_Frame_Shift_Ins_p.S215fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.S83fs|TP53_uc010cng.1_Frame_Shift_Ins_p.S83fs|TP53_uc002gii.1_Frame_Shift_Ins_p.S83fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.S215fs|TP53_uc010cni.1_Frame_Shift_Ins_p.S215fs|TP53_uc002gij.2_Frame_Shift_Ins_p.S215fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Ins_p.S122fs|TP53_uc002gio.2_Frame_Shift_Ins_p.S83fs|TP53_uc010vug.1_Frame_Shift_Ins_p.S176fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	215	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		S -> R (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> K (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|S -> N (in sporadic cancers; somatic mutation).|S -> T (in sporadic cancers; somatic mutation).|S -> G (in sporadic cancers; somatic mutation).|S -> I (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S215R(16)|p.S215I(15)|p.0?(7)|p.S215G(6)|p.S215N(6)|p.S215C(5)|p.S215fs*32(4)|p.S215T(3)|p.S215S(2)|p.H214fs*5(2)|p.K164_P219del(1)|p.H214fs*7(1)|p.S215fs*27(1)|p.S215del(1)|p.H214_S215insX(1)|p.D208_V216delDRNTFRHSV(1)|p.S215fs*29(1)|p.T211_S215delTFRHS(1)|p.D208fs*1(1)|p.S215fs*31(1)|p.S215_V218>R(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.S215_V216insX(1)|p.R213fs*32(1)|p.R209fs*6(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACCACCACACTATGTCGAAAA	0.535		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---								T	7578206	T	T	7578205	7	5	300	1	0	1	1	0	0	0	0	0	16448	565	20	0	650	0	TP53	17	7578205	Frame_Shift_Ins	INS	-	TCGA-HD-7831-01A-11D-2129-08		7578205	73617005	37	55325											
SOCS6	9306	broad.mit.edu	37	chr18	67992652	67992652	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagctcttctcccatggaaGtctctgcggttcctcctcaa	7	12	7	15	1	4	0	1	0	3	0	8	1	6	1	3	2	2	2	3	2	2	2			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr18:67992652G>A	uc002lkr.1	+	2	1064	c.748G>A	c.(748-750)GTC>ATC	p.V250I	SOCS6_uc010dqq.2_Missense_Mutation_p.V250I	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	250					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				TCCCATGGAAGTCTCTGCGGT	0.537													18	81					0	0	0	0	A	67992652	A	A	67992652	3	1	300	1	0	0	0	0	1	0	0	0	14982	1029	36	4	750	4	SOCS6	18	67992652	Missense_Mutation	SNP	G	TCGA-HD-7831-01A-11D-2129-08		67992652	10084596	38	55326											
ANKRD24	170961	broad.mit.edu	37	chr19	4219650	4219650	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccgaggcacagctggccacAgcagagcagcagctacgggg	10	2	16	13	2	0	1	0	0	0	1	0	2	0	1	2	4	6	6	2	4	1	1			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr19:4219650A>T	uc010dtt.1	+	19	3342	c.3066A>T	c.(3064-3066)ACA>ACT	p.T1022T		NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	1022	Potential.										0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		AGCTGGCCACAGCAGAGCAGC	0.652													9	68					0	0	0	0	T	4219650	T	T	4219650	2	4	300	1	0	0	0	0	0	0	0	1	653	175	7	5		5	ANKRD24	19	4219650	Silent	SNP	A	TCGA-HD-7831-01A-11D-2129-08		4219650	54909333	39	55327											
FBN3	84467	broad.mit.edu	37	chr19	8152012	8152012	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgcatgcctgggggacagaCgcacgcgaaggtaccgatga	10	4	15	12	5	0	2	0	1	0	1	0	5	0	3	3	3	2	3	3	3	2	1			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr19:8152012C>T	uc002mjf.2	-	53	6724	c.6703G>A	c.(6703-6705)GTC>ATC	p.V2235I	FBN3_uc002mje.2_Missense_Mutation_p.V74I	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2235	EGF-like 36; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGGGGACAGACGCACGCGAAG	0.627													9	58					0	0	0	0	T	8152012	T	T	8152012	3	4	300	1	0	0	0	0	1	0	0	0	5736	536	19	1	1770	1	FBN3	19	8152012	Missense_Mutation	SNP	C	TCGA-HD-7831-01A-11D-2129-08	3932362	8152012	50976971	40	55328											
ZNF85	7639	broad.mit.edu	37	chr19	21132642	21132642	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttttaaccaatcctcaaaacTtactgaacataagaaaattc	18	12	2	9	0	1	2	1	1	0	1	3	2	2	2	2	0	4	0	2	0	9	5			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr19:21132642T>C	uc002npg.3	+	4	1449	c.1322T>C	c.(1321-1323)CTT>CCT	p.L441P	ZNF85_uc010ecn.2_Missense_Mutation_p.L376P|ZNF85_uc010eco.2_Missense_Mutation_p.L389P|ZNF85_uc002npi.2_Missense_Mutation_p.L382P	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	441	C2H2-type 11; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1						TCCTCAAAACTTACTGAACAT	0.323													3	20					0	0	0	0	C	21132642	C	C	21132642	3	2	300	1	0	0	0	0	1	0	0	0	18260	1609	56	5	1336	5	ZNF85	19	21132642	Missense_Mutation	SNP	T	TCGA-HD-7831-01A-11D-2129-08	12980630	21132642	37996341	41	55329											
ZNF98	148198	broad.mit.edu	37	chr19	22575302	22575302	+	Frame_Shift_Del	DEL	T	-	-																															tgtgagagccggttaaaggcTtttccacactcttcgcattt																										TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr19:22575302delT	uc002nqt.2	-	4	857	c.735delA	c.(733-735)AAAfs	p.K245fs		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	245	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				GGTTAAAGGCTTTTCCACACT	0.393													---	---	---								-	22575302	-	-	22575302	7	5	300	1	0	1	0	1	0	0	0	0	18270	1606	56	0	987	0	ZNF98	19	22575302	Frame_Shift_Del	DEL	T	TCGA-HD-7831-01A-11D-2129-08	1442660	22575302	36553681	42	55330											
LBP	3929	broad.mit.edu	37	chr20	37001732	37001732	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaggcagagctgttggaagCgctcctcaactattacatcc	10	9	9	13	1	1	1	1	0	0	1	3	2	3	2	3	2	4	4	3	2	4	3			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr20:37001732C>T	uc002xic.1	+	13	1312	c.1277C>T	c.(1276-1278)GCG>GTG	p.A426V		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	426					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				CTGTTGGAAGCGCTCCTCAAC	0.398													9	66					0	0	0	0	T	37001732	T	T	37001732	3	4	300	1	0	0	0	0	1	0	0	0	8691	768	27	1	1327	1	LBP	20	37001732	Missense_Mutation	SNP	C	TCGA-HD-7831-01A-11D-2129-08		37001732	26023788	43	55331											
SLC5A1	6523	broad.mit.edu	37	chr22	32506120	32506120	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	tgacggacacctctgagaagCctttgtggaggacagtgttg	9	10	14	8	1	1	2	0	2	1	1	1	6	1	5	2	3	1	1	2	3	1	2			TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr22:32506120C>G	uc003amc.2	+	15	2147	c.1915C>G	c.(1915-1917)CCT>GCT	p.P639A	SLC5A1_uc011alz.1_Missense_Mutation_p.P512A	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	639	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						CTCTGAGAAGCCTTTGTGGAG	0.493													4	71					0	0	0	0	G	32506120	G	G	32506120	3	3	300	1	0	0	0	0	1	0	0	0	14725	739	26	4	1973	4	SLC5A1	22	32506120	Missense_Mutation	SNP	C	TCGA-HD-7831-01A-11D-2129-08		32506120	18798446	44	55332											
ELFN2	114794	broad.mit.edu	37	chr22	37770213	37770213	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcccagcttctgggcggcGtgcacaatggagccggcatc	6	7	14	14	4	1	0	0	0	1	0	3	1	1	1	2	4	3	3	2	4	1	1	rs145219811		TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chr22:37770213G>A	uc003asq.3	-	3	2148	c.1362C>T	c.(1360-1362)CAC>CAT	p.H454H		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	454	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					TCTGGGCGGCGTGCACAATGG	0.637													9	166					0	0	0	0	A	37770213	A	A	37770213	2	1	300	1	0	0	0	0	0	0	0	1	5082	1136	40	1		1	ELFN2	22	37770213	Silent	SNP	G	TCGA-HD-7831-01A-11D-2129-08	5264093	37770213	13534353	45	55333											
ZC3H12B	340554	broad.mit.edu	37	chrX	64719029	64719037	+	In_Frame_Del	DEL	ACTACCGAG	-	-																															catcattgtgtccaatgataActaccgagaccttcaagttg																										TCGA-HD-7831-01A-11D-2129-08	TCGA-HD-7831-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae914215-3b1a-4edb-9f5a-ce4a17154178	5e5678fa-37f6-4987-bca3-33b46233e80a	g.chrX:64719029_64719037delACTACCGAG	uc010nko.2	+	3	875_883	c.866_874delACTACCGAG	c.(865-876)AACTACCGAGAC>AAC	p.YRD290del		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	290_292							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						TCCAATGATAACTACCGAGACCTTCAAGT	0.445													---	---	---								-	64719037	-	-	64719029	7	5	300	1	0	1	0	1	0	0	0	0	17629	43	2	0	909	0	ZC3H12B	23	64719029	In_Frame_Del	DEL	ACTACCGAG	TCGA-HD-7831-01A-11D-2129-08		64719029	90551531	46	55334											
KIF1B	23095	broad.mit.edu	37	chr1	10356659	10356659	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttatcgtgaccttagagccCtgtgagcgctcagaaaccta	10	10	10	11	2	1	4	1	2	0	2	2	4	1	4	3	0	3	2	3	0	4	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:10356659C>T	uc001aqx.3	+	20	1999	c.1797C>T	c.(1795-1797)CCC>CCT	p.P599P	KIF1B_uc001aqv.3_Silent_p.P553P|KIF1B_uc001aqw.3_Silent_p.P553P|KIF1B_uc001aqy.2_Silent_p.P573P|KIF1B_uc001aqz.2_Silent_p.P599P|KIF1B_uc001ara.2_Silent_p.P559P|KIF1B_uc001arb.2_Silent_p.P585P	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	599	FHA.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CCTTAGAGCCCTGTGAGCGCT	0.443													17	19					0	0	0	0	T	10356659	T	T	10356659	2	4	301	1	0	0	0	0	0	0	0	1	8323	668	24	4		4	KIF1B	1	10356659	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08		10356659	238893962	1	55335											
CLCN6	1185	broad.mit.edu	37	chr1	11893658	11893658	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gccacactcttcttcaacccGcaggagtctgccatcctcca	8	9	6	18	1	4	0	1	0	3	0	6	1	6	1	5	1	2	1	5	1	1	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:11893658G>A	uc001ate.3	+	14	1448	c.1335G>A	c.(1333-1335)CCG>CCA	p.P445P	CLCN6_uc010oat.1_Silent_p.P161P|CLCN6_uc010oau.1_Silent_p.P423P	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	445					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TCTTCAACCCGCAGGAGTCTG	0.493													19	21					0	0	0	0	A	11893658	A	A	11893658	2	1	301	1	0	0	0	0	0	0	0	1	3482	1074	38	1		1	CLCN6	1	11893658	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08	1536999	11893658	237356963	2	55336											
UBXN10	127733	broad.mit.edu	37	chr1	20517058	20517058	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	aggggtcttgagaagcaatgGccacagaagcccctgtgaat	12	7	13	9	0	1	3	0	2	1	2	1	4	1	3	3	3	2	1	3	3	4	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:20517058G>A	uc001bdb.2	+	2	88	c.4G>A	c.(4-6)GCC>ACC	p.A2T		NM_152376	NP_689589	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	2										ovary(1)	1						AGAAGCAATGGCCACAGAAGC	0.502													41	73					0	0	0	0	A	20517058	A	A	20517058	3	1	301	1	0	0	0	0	1	0	0	0	16980	1203	42	4	6	4	UBXN10	1	20517058	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	8623400	20517058	228733563	3	55337											
NKAIN1	79570	broad.mit.edu	37	chr1	31655404	31655404	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcctccaggaacacttTgctcacgtagcaggcgaaca	10	8	8	15	2	1	0	1	0	0	0	4	2	4	1	3	2	4	3	3	2	3	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:31655404T>G	uc010ogd.1	-	5	511	c.505A>C	c.(505-507)AAA>CAA	p.K169Q	NKAIN1_uc001bsn.2_Missense_Mutation_p.K125Q|NKAIN1_uc010ogc.1_Missense_Mutation_p.K98Q	NM_024522	NP_078798	Q4KMZ8	NKAI1_HUMAN	Na+/K+ transporting ATPase interacting 1	169	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|Breast(348;0.141)|all_neural(195;0.146)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0184)|READ - Rectum adenocarcinoma(331;0.148)		AGGAACACTTTGCTCACGTAG	0.632													19	52					0	0	0	0	G	31655404	G	G	31655404	3	3	301	1	0	0	0	0	1	0	0	0	10489	1821	63	5	130	5	NKAIN1	1	31655404	Missense_Mutation	SNP	T	TCGA-HD-7832-01A-11D-2129-08	11138346	31655404	217595217	4	55338											
GRIK3	2899	broad.mit.edu	37	chr1	37271729	37271729	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	gggcgtgccgatgccgtagcCcttggagtcaatgaggcccc	6	7	15	13	3	1	1	1	1	0	0	1	3	1	2	5	3	3	1	5	3	2	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:37271729C>T	uc001caz.2	-	14	2425	c.2290G>A	c.(2290-2292)GGC>AGC	p.G764S	GRIK3_uc001cba.1_Missense_Mutation_p.G764S	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	764	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	ATGCCGTAGCCCTTGGAGTCA	0.667													25	45					0	0	0	0	T	37271729	T	T	37271729	3	4	301	1	0	0	0	0	1	0	0	0	6814	623	22	4	481	4	GRIK3	1	37271729	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	5616325	37271729	211978892	5	55339											
SPATA6	54558	broad.mit.edu	37	chr1	48869550	48869550	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aaaattccagccttggagcaTttccctgagaagaaaaaaga	17	8	8	8	0	0	3	0	1	0	3	2	5	2	4	3	1	2	1	3	1	6	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:48869550T>C	uc001crr.1	-	6	575	c.410A>G	c.(409-411)AAT>AGT	p.N137S	SPATA6_uc001crs.1_Missense_Mutation_p.N137S|SPATA6_uc010omv.1_Missense_Mutation_p.N123S|SPATA6_uc001crt.2_Missense_Mutation_p.N29S	NM_019073	NP_061946	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6 precursor	137					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				ovary(1)	1						CCTTGGAGCATTTCCCTGAGA	0.313													7	19					0	0	0	0	C	48869550	C	C	48869550	3	2	301	1	0	0	0	0	1	0	0	0	15079	1493	52	5	1088	5	SPATA6	1	48869550	Missense_Mutation	SNP	T	TCGA-HD-7832-01A-11D-2129-08	11597821	48869550	200381071	6	55340											
ELAVL4	1996	broad.mit.edu	37	chr1	50663122	50663122	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctggacaatttgcttaatatGgcctatggcgtaaagaggta	12	12	11	6	1	0	1	0	0	0	1	0	2	0	2	1	4	1	3	1	4	7	6			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:50663122G>A	uc001csb.2	+	6	1024	c.756G>A	c.(754-756)ATG>ATA	p.M252I	ELAVL4_uc001cry.3_Missense_Mutation_p.M255I|ELAVL4_uc001crz.3_Missense_Mutation_p.M252I|ELAVL4_uc001csa.3_Missense_Mutation_p.M269I|ELAVL4_uc001csc.3_Missense_Mutation_p.M252I|ELAVL4_uc009vyu.2_Missense_Mutation_p.M257I|ELAVL4_uc010omz.1_Missense_Mutation_p.M257I	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	252					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						TGCTTAATATGGCCTATGGCG	0.403													55	109					0	0	0	0	A	50663122	A	A	50663122	3	1	301	1	0	0	0	0	1	0	0	0	5076	1348	47	4	877	4	ELAVL4	1	50663122	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	1793572	50663122	198587499	7	55341											
C1orf173	127254	broad.mit.edu	37	chr1	75038685	75038685	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctgctgcttcatttgcaagCactgccttctctaaaccctg	7	13	7	14	0	2	0	1	0	1	0	3	0	2	0	2	0	6	5	2	0	3	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:75038685C>A	uc001dgg.2	-	14	2928	c.2709G>T	c.(2707-2709)GTG>GTT	p.V903V		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	903	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CATTTGCAAGCACTGCCTTCT	0.532													78	171					1.07134e-49	1.18851e-49	1	0	A	75038685	A	A	75038685	2	1	301	1	0	0	0	0	0	0	0	1	2023	697	25	4		4	C1orf173	1	75038685	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08	24375563	75038685	174211936	8	55342											
WDR63	126820	broad.mit.edu	37	chr1	85555914	85555914	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcttaacaatgcatccataAggtaaaaaattgcatattaa	18	13	4	6	0	1	0	0	0	1	0	2	0	2	0	1	1	3	3	1	1	8	7			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:85555914A>T	uc001dkt.2	+	8	1047	c.856A>T	c.(856-858)AGT>TGT	p.S286C	WDR63_uc009wcl.2_Intron	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	286										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TGCATCCATAAGGTAAAAAAT	0.274													20	21					0	0	0	0	T	85555914	T	T	85555914	3	4	301	1	0	0	0	0	1	0	0	0	17382	86	3	5	882	5	WDR63	1	85555914	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08	10517229	85555914	163694707	9	55343											
EVI5	7813	broad.mit.edu	37	chr1	93202126	93202127	+	In_Frame_Ins	INS	-	TGT	TGT																															actgactgtatgcgatactgINStgttcttcacccatgagaga																										TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:93202126_93202127insTGT	uc001dox.2	-	2	119_120	c.109_110insACA	c.(109-111)ACA>AACACA	p.36_37insN	EVI5_uc010otf.1_In_Frame_Ins_p.36_37insN	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	36_37	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		ATGCGATACTGTGTTCTTCACC	0.436													---	---	---								TGT	93202127	TGT	TGT	93202126	7	5	301	1	0	1	1	0	0	0	0	0	5313	1377	48	0	2390	0	EVI5	1	93202126	In_Frame_Ins	INS	-	TCGA-HD-7832-01A-11D-2129-08	7646212	93202126	156048495	10	55344											
KPRP	448834	broad.mit.edu	37	chr1	152732834	152732834	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gagcaccagcagatgccttcCtcctcctcggcggctgcagc	6	7	11	17	2	0	1	0	0	0	1	4	2	3	1	5	2	5	4	5	2	0	1	rs147534038	byFrequency	TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:152732834C>T	uc001fal.1	+	2	828	c.770C>T	c.(769-771)CCT>CTT	p.P257L		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	257	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGATGCCTTCCTCCTCCTCGG	0.607													32	44					0	0	0	0	T	152732834	T	T	152732834	3	4	301	1	0	0	0	0	1	0	0	0	8475	681	24	4	772	4	KPRP	1	152732834	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	59530708	152732834	96517787	11	55345											
C1orf125	126859	broad.mit.edu	37	chr1	179354444	179354444	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atatttcatgaacttattcgAcaagtcagtgtggactgtgc	11	14	9	7	1	2	1	2	1	0	0	3	3	2	2	0	1	2	0	0	1	4	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:179354444A>G	uc001gmo.2	+	9	940	c.813A>G	c.(811-813)CGA>CGG	p.R271R	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Silent_p.R59R|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Silent_p.R271R	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	271											0						AACTTATTCGACAAGTCAGTG	0.358													57	24					0	0	0	0	G	179354444	G	G	179354444	2	3	301	1	0	0	0	0	0	0	0	1	2002	262	10	5		5	C1orf125	1	179354444	Silent	SNP	A	TCGA-HD-7832-01A-11D-2129-08	26621610	179354444	69896177	12	55346											
KCTD3	51133	broad.mit.edu	37	chr1	215775237	215775237	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tgttgttcctataactagttAtgacactgctggatcattcc	9	16	7	9	0	1	1	1	1	0	0	3	2	3	2	2	1	2	4	2	1	4	7			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:215775237A>G	uc001hks.2	+	11	1256	c.962A>G	c.(961-963)TAT>TGT	p.Y321C	KCTD3_uc001hkt.2_Missense_Mutation_p.Y321C|KCTD3_uc010pub.1_Missense_Mutation_p.Y219C|KCTD3_uc009xdn.2_Missense_Mutation_p.Y73C	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	321	WD 3.					voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		ATAACTAGTTATGACACTGCT	0.323													17	31					0	0	0	0	G	215775237	G	G	215775237	3	3	301	1	0	0	0	0	1	0	0	0	8149	449	16	5	1004	5	KCTD3	1	215775237	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08	36420793	215775237	33475384	13	55347											
OR1C1	26188	broad.mit.edu	37	chr1	247921166	247921166	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagctgcaggagaggattGagatcacagaagaaatgatg	16	6	15	4	0	1	6	1	2	0	5	1	10	1	7	0	2	2	2	0	2	2	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr1:247921166G>A	uc010pza.1	-	1	543	c.543C>T	c.(541-543)CTC>CTT	p.L181L		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGAGAGGATTGAGATCACAGA	0.478													8	12					0	0	0	0	A	247921166	A	A	247921166	2	1	301	1	0	0	0	0	0	0	0	1	11006	1277	45	2		2	OR1C1	1	247921166	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08	32145929	247921166	1329455	14	55348											
SOX11	6664	broad.mit.edu	37	chr2	5833021	5833021	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagcggccgatgaacgcgttCatggtatggtccaagatcga	11	8	13	9	5	1	2	1	1	0	1	3	4	2	2	2	3	2	2	2	3	4	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr2:5833021C>T	uc002qyj.2	+	1	223	c.168C>T	c.(166-168)TTC>TTT	p.F56F		NM_003108	NP_003099	P35716	SOX11_HUMAN	SRY-box 11	56	HMG box.				cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(3)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		TGAACGCGTTCATGGTATGGT	0.602													6	11					0	0	0	0	T	5833021	T	T	5833021	2	4	301	1	0	0	0	0	0	0	0	1	15006	825	29	2		2	SOX11	2	5833021	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08		5833021	237366352	15	55349											
TGOLN2	10618	broad.mit.edu	37	chr2	85554437	85554437	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtctgcgcctccgcacccgAtttgccagtgctgtcttttg	3	13	11	14	3	2	0	0	0	2	0	3	1	3	0	4	1	3	2	4	1	0	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr2:85554437A>G	uc010fgd.1	-	2	707	c.418T>C	c.(418-420)TCG>CCG	p.S140P	TGOLN2_uc002soz.2_Missense_Mutation_p.S140P|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_Missense_Mutation_p.S140P|TGOLN2_uc002spc.1_Missense_Mutation_p.S140P	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	140	Extracellular (Potential).|7.|14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						TCCGCACCCGATTTGCCAGTG	0.592													201	358					0	0	0	0	G	85554437	G	G	85554437	3	3	301	1	0	0	0	0	1	0	0	0	15902	333	12	5	907	5	TGOLN2	2	85554437	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08	79721416	85554437	157644936	16	55350											
IL1R1	3554	broad.mit.edu	37	chr2	102782600	102782600	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aacctctacttcttgacaatAtacactttagtggagtcaaa	14	13	5	9	0	3	1	1	1	2	0	3	2	3	2	1	1	3	0	1	1	7	7			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr2:102782600A>G	uc002tbq.2	+	6	832	c.514A>G	c.(514-516)ATA>GTA	p.I172V	IL1R1_uc010fix.2_Missense_Mutation_p.I172V|IL1R1_uc002tbp.2_Missense_Mutation_p.I172V|IL1R1_uc002tbr.2_Missense_Mutation_p.I172V	NM_000877	NP_000868	P14778	IL1R1_HUMAN	interleukin 1 receptor, type I precursor	172	Extracellular (Potential).|Ig-like C2-type 2.				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			skin(1)	1					Anakinra(DB00026)	TCTTGACAATATACACTTTAG	0.413													24	40					0	0	0	0	G	102782600	G	G	102782600	3	3	301	1	0	0	0	0	1	0	0	0	7697	449	16	5	528	5	IL1R1	2	102782600	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08	17228163	102782600	140416773	17	55351											
WDR33	55339	broad.mit.edu	37	chr2	128480839	128480839	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agtctcaccatattctactcCatcttcagacattccaggta	11	13	4	13	0	4	1	2	0	3	1	7	1	6	1	3	1	1	1	3	1	3	6			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr2:128480839C>T	uc002tpg.1	-	12	1462	c.1279G>A	c.(1279-1281)GGA>AGA	p.G427R		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	427					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TATTCTACTCCATCTTCAGAC	0.348													40	99					0	0	0	0	T	128480839	T	T	128480839	3	4	301	1	0	0	0	0	1	0	0	0	17355	603	21	4	2775	4	WDR33	2	128480839	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	25698239	128480839	114718534	18	55352											
TTN	7273	broad.mit.edu	37	chr2	179588170	179588170	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaaagagacgggtagtgcaAgatgcttggccagcgttgtt	11	9	14	7	2	0	2	0	0	0	2	0	3	0	2	1	2	3	5	1	2	3	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr2:179588170A>T	uc010zfg.1	-	71	18149	c.17925T>A	c.(17923-17925)TCT>TCA	p.S5975S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.S2636S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6902							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTAGTGCAAGATGCTTGGC	0.403													9	17					0	0	0	0	T	179588170	T	T	179588170	2	4	301	1	0	0	0	0	0	0	0	1	16803	59	3	5		5	TTN	2	179588170	Silent	SNP	A	TCGA-HD-7832-01A-11D-2129-08	51107331	179588170	63611203	19	55353											
TTN	7273	broad.mit.edu	37	chr2	179654095	179654095	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aacaatagtcacctttccatGggtaacttggatttgttctt	10	16	7	8	0	2	0	1	0	1	0	3	1	3	1	2	2	2	2	2	2	4	7			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr2:179654095G>C	uc010zfg.1	-	13	2292	c.2068C>G	c.(2068-2070)CAT>GAT	p.H690D	TTN_uc010zfh.1_Missense_Mutation_p.H644D|TTN_uc010zfi.1_Missense_Mutation_p.H644D|TTN_uc010zfj.1_Missense_Mutation_p.H644D|TTN_uc002unb.2_Missense_Mutation_p.H690D|TTN_uc010frg.1_Missense_Mutation_p.H272D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	690							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTTCCATGGGTAACTTGG	0.338													37	77					0	0	0	0	C	179654095	C	C	179654095	3	2	301	1	0	0	0	0	1	0	0	0	16803	1348	47	4	109320	4	TTN	2	179654095	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	65925	179654095	63545278	20	55354											
DNAH7	56171	broad.mit.edu	37	chr2	196726633	196726633	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttcaatttcttccaagaatCgtgaggcaactgcctggagt	10	13	9	9	1	2	2	1	1	1	1	4	3	3	3	2	2	2	1	2	2	4	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr2:196726633C>T	uc002utj.3	-	42	7645	c.7544G>A	c.(7543-7545)CGA>CAA	p.R2515Q		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2515	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTCCAAGAATCGTGAGGCAAC	0.378													18	33					0	0	0	0	T	196726633	T	T	196726633	3	4	301	1	0	0	0	0	1	0	0	0	4628	884	31	1	4626	1	DNAH7	2	196726633	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	17072538	196726633	46472740	21	55355											
ATG16L1	55054	broad.mit.edu	37	chr2	234198586	234198586	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtctcaggaagtcacgaccgGactctcaaactctgggatct	10	9	10	12	2	5	0	3	0	4	0	7	4	5	3	1	3	1	0	1	3	2	0			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr2:234198586G>A	uc002vty.2	+	13	1547	c.1290G>A	c.(1288-1290)CGG>CGA	p.R430R	ATG16L1_uc002vtx.1_Silent_p.R267R|ATG16L1_uc002vua.2_Silent_p.R411R|ATG16L1_uc002vub.2_Silent_p.R288R|ATG16L1_uc002vtz.2_Silent_p.R251R|ATG16L1_uc002vud.3_Silent_p.R346R	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	430	WD 3.				autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GTCACGACCGGACTCTCAAAC	0.502													18	41					0	0	0	0	A	234198586	A	A	234198586	2	1	301	1	0	0	0	0	0	0	0	1	1093	1161	41	2		2	ATG16L1	2	234198586	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08	37471953	234198586	9000787	22	55356											
ASB1	51665	broad.mit.edu	37	chr2	239342262	239342262	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggagcactgtgaggacacGaggctccatgatgcagctta	10	8	13	10	1	0	2	0	2	0	0	1	5	1	4	1	3	3	4	1	3	1	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr2:239342262G>A	uc002vyg.2	+	2	203	c.117G>A	c.(115-117)ACG>ACA	p.T39T		NM_001040445	NP_001035535	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box-containing protein	39	ANK 1.				intracellular signal transduction|negative regulation of cytokine biosynthetic process						0		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		GTGAGGACACGAGGCTCCATG	0.587													10	22					0	0	0	0	A	239342262	A	A	239342262	2	1	301	1	0	0	0	0	0	0	0	1	1015	1045	37	1		1	ASB1	2	239342262	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08	5143676	239342262	3857111	23	55357											
PLA1A	51365	broad.mit.edu	37	chr3	119327618	119327618	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	tttttggccccctgtctaggGttttaggaacaaagccttcc	7	14	9	11	0	1	0	0	0	1	0	2	1	2	1	4	3	2	1	4	3	4	6			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr3:119327618G>T	uc003ecu.2	+	3	316	c.277G>T	c.(277-279)GTT>TTT	p.V93F	PLA1A_uc003ecv.2_Missense_Mutation_p.V93F|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_5'UTR	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	93					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCTGTCTAGGGTTTTAGGAAC	0.408													44	137					3.86236e-30	4.25159e-30	1	0	T	119327618	T	T	119327618	3	4	301	1	0	0	0	0	1	0	0	0	12043	1275	44	4	287	4	PLA1A	3	119327618	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08		119327618	78694812	24	55358											
SEMA5B	54437	broad.mit.edu	37	chr3	122634428	122634428	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcacatggttgccatggtGaccatgggccgaagccccca	8	7	12	14	1	1	1	1	1	0	0	1	2	1	1	5	3	2	2	5	3	1	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr3:122634428G>A	uc003efz.1	-	14	2151	c.1847C>T	c.(1846-1848)TCA>TTA	p.S616L	SEMA5B_uc011bju.1_Missense_Mutation_p.S558L|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.S616L|SEMA5B_uc010hro.1_Missense_Mutation_p.S558L	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	616	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TTGCCATGGTGACCATGGGCC	0.587													13	52					0	0	0	0	A	122634428	A	A	122634428	3	1	301	1	0	0	0	0	1	0	0	0	14103	1294	45	2	1648	2	SEMA5B	3	122634428	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	3306810	122634428	75388002	25	55359											
GMPS	8833	broad.mit.edu	37	chr3	155652794	155652794	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggggtgctcagtactttacGccaagctgattttgaggccc	8	11	12	10	1	1	2	1	2	0	0	1	2	1	2	2	3	4	3	2	3	3	5			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr3:155652794G>T	uc003faq.2	+	14	2101	c.1766G>T	c.(1765-1767)CGC>CTC	p.R589L	GMPS_uc011bom.1_Missense_Mutation_p.R490L	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	589					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AGTACTTTACGCCAAGCTGAT	0.408			T	MLL	AML								58	162					3.77215e-22	4.0889e-22	1	0	T	155652794	T	T	155652794	3	4	301	1	0	0	0	0	1	0	0	0	6535	1087	38	3	1820	3	GMPS	3	155652794	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	33018366	155652794	42369636	26	55360											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	14	8	8	11	1	3	4	1	2	2	2	5	6	4	4	1	1	2	1	1	1	3	1	rs121913273		TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			12	46					0	0	0	0	A	178936082	A	A	178936082	3	1	301	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1658	2	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	23283288	178936082	19086348	27	55361											
MUC7	4589	broad.mit.edu	37	chr4	71346725	71346725	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cccaaattcccaaatcctcaCcagccacctaaacatccaga	15	6	2	18	0	1	1	1	0	0	1	4	1	4	1	7	0	2	0	7	0	4	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr4:71346725C>T	uc011cat.1	+	4	552	c.264C>T	c.(262-264)CAC>CAT	p.H88H	MUC7_uc011cau.1_Silent_p.H88H|MUC7_uc003hfj.2_Silent_p.H88H|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	88						extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			CAAATCCTCACCAGCCACCTA	0.458													29	65					0	0	0	0	T	71346725	T	T	71346725	2	4	301	1	0	0	0	0	0	0	0	1	10034	506	18	4		4	MUC7	4	71346725	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08		71346725	119807551	28	55362											
INTU	27152	broad.mit.edu	37	chr4	128564981	128564981	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tcagtccaatcagaagacagGagtcattgtccaacagcgat	14	8	9	10	1	3	2	3	0	0	2	5	4	5	3	2	1	2	0	2	1	3	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr4:128564981G>A	uc003ifk.1	+	2	522	c.452G>A	c.(451-453)GGA>GAA	p.G151E	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	151										ovary(1)	1						CAGAAGACAGGAGTCATTGTC	0.388													36	63					0	0	0	0	A	128564981	A	A	128564981	3	1	301	1	0	0	0	0	1	0	0	0	7825	1174	41	2	458	2	INTU	4	128564981	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	57218256	128564981	62589295	29	55363											
TBC1D9	23158	broad.mit.edu	37	chr4	141543481	141543481	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagtacttgaccagggcaggCtcagttaagagggaggccag	12	6	15	8	0	1	2	1	1	0	1	1	3	1	3	2	4	1	4	2	4	3	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr4:141543481C>T	uc010ioj.2	-	21	3941	c.3669G>A	c.(3667-3669)GAG>GAA	p.E1223E		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	1223						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CCAGGGCAGGCTCAGTTAAGA	0.627													9	14					0	0	0	0	T	141543481	T	T	141543481	2	4	301	1	0	0	0	0	0	0	0	1	15693	796	28	4		4	TBC1D9	4	141543481	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08	12978500	141543481	49610795	30	55364											
CD180	4064	broad.mit.edu	37	chr5	66479050	66479050	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gtagattcccttaagatggcTaagagaatcaatgctgtcgc	12	11	10	8	1	1	3	1	0	0	3	3	4	2	3	1	1	1	3	1	1	5	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr5:66479050T>C	uc003juy.2	-	3	1769	c.1621A>G	c.(1621-1623)AGC>GGC	p.S541G		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	541	LRR 18.|Extracellular (Potential).				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TTAAGATGGCTAAGAGAATCA	0.468													9	53					0	0	0	0	C	66479050	C	C	66479050	3	2	301	1	0	0	0	0	1	0	0	0	2987	1522	53	5	368	5	CD180	5	66479050	Missense_Mutation	SNP	T	TCGA-HD-7832-01A-11D-2129-08		66479050	114436210	31	55365											
FBN2	2201	broad.mit.edu	37	chr5	127595365	127595365	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gatgcggaagacgctgtcatCgttcccttgagagatgacat	10	10	12	9	3	1	4	1	2	0	2	3	7	2	5	1	1	1	2	1	1	1	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr5:127595365C>T	uc003kuu.2	-	65	8960	c.8521G>A	c.(8521-8523)GAT>AAT	p.D2841N		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2841					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ACGCTGTCATCGTTCCCTTGA	0.547													34	105					0	0	0	0	T	127595365	T	T	127595365	3	4	301	1	0	0	0	0	1	0	0	0	5735	884	31	1	221	1	FBN2	5	127595365	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	61116315	127595365	53319895	32	55366											
ADAMTS19	171019	broad.mit.edu	37	chr5	128977612	128977612	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	agaaagaatgcagaaccaagCtagacccaccaatggatgga	18	4	10	9	0	0	4	0	0	0	4	0	6	0	6	3	2	3	2	3	2	6	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr5:128977612C>T	uc003kvb.1	+	11	1813	c.1813C>T	c.(1813-1815)CTA>TTA	p.L605L	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	605	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CAGAACCAAGCTAGACCCACC	0.398													19	75					0	0	0	0	T	128977612	T	T	128977612	2	4	301	1	0	0	0	0	0	0	0	1	264	796	28	4		4	ADAMTS19	5	128977612	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08	1382247	128977612	51937648	33	55367											
PCDHGC3	5098	broad.mit.edu	37	chr5	140857271	140857271	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcccctagactatgaggatCggcgggaatttgaattaaca	12	10	11	8	2	0	3	0	2	0	1	1	5	0	5	2	3	2	0	2	3	5	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr5:140857271C>T	uc003lkv.1	+	1	1703	c.1588C>T	c.(1588-1590)CGG>TGG	p.R530W	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Missense_Mutation_p.R530W|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	530	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATGAGGATCGGCGGGAATT	0.493													17	51					0	0	0	0	T	140857271	T	T	140857271	3	4	301	1	0	0	0	0	1	0	0	0	11623	875	31	1	1590	1	PCDHGC3	5	140857271	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	11879659	140857271	40057989	34	55368											
PPARGC1B	133522	broad.mit.edu	37	chr5	149216430	149216430	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agcagcggcgagagcagcttCctcccagaggaggaagagga	12	3	16	10	2	0	3	0	0	0	3	2	7	2	6	2	4	4	3	2	4	1	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr5:149216430C>T	uc003lrc.2	+	8	2454	c.2412C>T	c.(2410-2412)TTC>TTT	p.F804F	PPARGC1B_uc003lrb.1_Silent_p.F804F|PPARGC1B_uc003lrd.2_Silent_p.F765F|PPARGC1B_uc003lrf.2_Silent_p.F783F|PPARGC1B_uc003lre.1_Silent_p.F783F	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	804	Glu-rich.				estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AGAGCAGCTTCCTCCCAgagg	0.458													122	24					0	0	0	0	T	149216430	T	T	149216430	2	4	301	1	0	0	0	0	0	0	0	1	12356	854	30	2		2	PPARGC1B	5	149216430	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08	8359159	149216430	31698830	35	55369											
SNX14	57231	broad.mit.edu	37	chr6	86259572	86259572	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccatattcttctaaagcagcTtgctgtaaaaactctgtatt	12	15	5	9	0	3	0	0	0	3	0	3	0	3	0	1	0	4	5	1	0	7	8			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr6:86259572T>C	uc003pkr.2	-	8	853	c.660A>G	c.(658-660)CAA>CAG	p.Q220Q	SNX14_uc003pkp.2_Silent_p.Q83Q|SNX14_uc003pkq.2_5'UTR|SNX14_uc011dzg.1_Silent_p.Q168Q|SNX14_uc003pks.2_Silent_p.Q176Q|SNX14_uc003pkt.2_Silent_p.Q220Q	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	220	PXA.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CTAAAGCAGCTTGCTGTAAAA	0.308													23	42					0	0	0	0	C	86259572	C	C	86259572	2	2	301	1	0	0	0	0	0	0	0	1	14949	1606	56	5		5	SNX14	6	86259572	Silent	SNP	T	TCGA-HD-7832-01A-11D-2129-08		86259572	84855495	36	55370											
WDR27	253769	broad.mit.edu	37	chr6	170052099	170052099	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtccttcatgacgttccGtgcagctgtggaaaggcaat	8	12	12	9	2	1	1	1	1	0	0	3	2	3	2	2	3	2	4	2	3	2	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr6:170052099G>A	uc003qwx.2	-	14	1928	c.1408C>T	c.(1408-1410)CGG>TGG	p.R470W	WDR27_uc003qwv.1_RNA|WDR27_uc010kkw.1_Missense_Mutation_p.R470W|WDR27_uc003qwy.2_Missense_Mutation_p.R343W			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	440										pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		ATGACGTTCCGTGCAGCTGTG	0.413													9	19					0	0	0	0	A	170052099	A	A	170052099	3	1	301	1	0	0	0	0	1	0	0	0	17352	1144	40	1	1213	1	WDR27	6	170052099	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	83792527	170052099	1062968	37	55371											
SDK1	221935	broad.mit.edu	37	chr7	4198148	4198148	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cattggggacagtgacttcaGttcagagacagaggcggtga	11	8	15	7	1	2	4	2	2	0	2	2	6	2	5	0	4	0	1	0	4	0	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr7:4198148G>A	uc003smx.2	+	31	4833	c.4694G>A	c.(4693-4695)AGT>AAT	p.S1565N	SDK1_uc010kso.2_Missense_Mutation_p.S841N|SDK1_uc003smy.2_Missense_Mutation_p.S52N	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1565	Fibronectin type-III 9.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGTGACTTCAGTTCAGAGACA	0.627													15	51					0	0	0	0	A	4198148	A	A	4198148	3	1	301	1	0	0	0	0	1	0	0	0	14033	1029	36	4	4816	4	SDK1	7	4198148	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08		4198148	154940515	38	55372											
ANLN	54443	broad.mit.edu	37	chr7	36456706	36456706	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taggtttcactgaatgcgaaAtgacgaaatctagccctttg	12	12	9	8	2	2	2	1	2	1	0	2	4	2	2	1	1	2	1	1	1	5	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr7:36456706A>C	uc003tff.2	+	9	1744	c.1540A>C	c.(1540-1542)ATG>CTG	p.M514L	ANLN_uc011kaz.1_Missense_Mutation_p.M426L|ANLN_uc003tfg.2_Intron|ANLN_uc010kxe.2_Intron	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	514	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						TGAATGCGAAATGACGAAATC	0.294													20	23					0	0	0	0	C	36456706	C	C	36456706	3	2	301	1	0	0	0	0	1	0	0	0	694	101	4	5	1574	5	ANLN	7	36456706	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08	32258558	36456706	122681957	39	55373											
SFRP4	6424	broad.mit.edu	37	chr7	37951727	37951727	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ctctttgtgcctaccttgagCgccactcgtaacacatgatg	8	12	8	13	2	1	2	0	2	1	0	2	2	1	2	3	0	4	1	3	0	2	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr7:37951727C>T	uc003tfo.3	-	4	1171	c.785G>A	c.(784-786)CGC>CAC	p.R262H		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	262	NTR.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						CTACCTTGAGCGCCACTCGTA	0.443													18	51					0	0	0	0	T	37951727	T	T	37951727	3	4	301	1	0	0	0	0	1	0	0	0	14228	768	27	1	267	1	SFRP4	7	37951727	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	1495021	37951727	121186936	40	55374											
CDK13	8621	broad.mit.edu	37	chr7	40134010	40134010	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagaaggtgggattgattatCaagcaggagacacttacgtg	13	9	14	5	1	1	3	1	1	0	2	1	6	1	4	0	3	2	1	0	3	4	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr7:40134010C>T	uc003thh.3	+	14	4252	c.3970C>T	c.(3970-3972)CAA>TAA	p.Q1324*	CDK13_uc003thi.3_Nonsense_Mutation_p.Q1264*|CDK13_uc003thj.2_Nonsense_Mutation_p.Q375*|CDK13_uc003thk.2_Nonsense_Mutation_p.Q257*	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	1324					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						GATTGATTATCAAGCAGGAGA	0.483													29	52					0	0	0	0	T	40134010	T	T	40134010	4	4	301	1	0	0	0	0	0	1	0	0	3144	827	29	2	4024	2	CDK13	7	40134010	Nonsense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	2182283	40134010	119004653	41	55375											
EGFR	1956	broad.mit.edu	37	chr7	55268060	55268060	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gttccgtgagttgatcatcgAattctccaaaatggcccgag	10	11	10	10	3	2	2	1	2	1	0	5	4	3	2	3	1	0	2	3	1	3	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr7:55268060A>C	uc003tqk.2	+	24	3146	c.2900A>C	c.(2899-2901)GAA>GCA	p.E967A	EGFR_uc010kzg.1_Missense_Mutation_p.E922A|EGFR_uc011kco.1_Missense_Mutation_p.E914A	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	967	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TTGATCATCGAATTCTCCAAA	0.473		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			41	70					0	0	0	0	C	55268060	C	C	55268060	3	2	301	1	0	0	0	0	1	0	0	0	4989	246	9	5	3258	5	EGFR	7	55268060	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08	15134050	55268060	103870603	42	55376											
MLL5	55904	broad.mit.edu	37	chr7	104753061	104753061	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaccctaccattcaccatCaaactgctgctgccgtagtc	11	9	6	15	1	2	1	2	0	0	1	3	1	2	1	4	0	6	3	4	0	4	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr7:104753061C>G	uc003vcm.2	+	27	5392	c.4858C>G	c.(4858-4860)CAA>GAA	p.Q1620E	MLL5_uc010ljc.2_Missense_Mutation_p.Q1620E|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.Q354E	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1620	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						CATTCACCATCAAACTGCTGC	0.552													38	82					0	0	0	0	G	104753061	G	G	104753061	3	3	301	1	0	0	0	0	1	0	0	0	9677	827	29	2	4956	2	MLL5	7	104753061	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	49485001	104753061	54385602	43	55377											
TRPV5	56302	broad.mit.edu	37	chr7	142605866	142605866	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtcccactctcagccccagaGggctgtttctcagatggatg	7	10	11	13	0	2	2	2	0	2	2	5	3	3	3	3	2	1	2	3	2	0	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr7:142605866G>T	uc003wby.1	-	15	2268	c.2004C>A	c.(2002-2004)CCC>CCA	p.P668P		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	668	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CAGCCCCAGAGGGCTGTTTCT	0.567													18	30					2.35188e-11	2.51103e-11	1	0	T	142605866	T	T	142605866	2	4	301	1	0	0	0	0	0	0	0	1	16666	987	35	4		4	TRPV5	7	142605866	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08	37852805	142605866	16532797	44	55378											
FAM150A	389658	broad.mit.edu	37	chr8	53452400	53452400	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	aagttacttacaagctggcgTtgagcactccctggtattgt	9	13	10	9	1	0	1	0	1	0	0	1	1	1	1	1	2	4	5	1	2	5	5			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr8:53452400T>C	uc003xrd.2	-	3	521	c.316A>G	c.(316-318)ACG>GCG	p.T106A	FAM150A_uc011ldt.1_Missense_Mutation_p.T106A	NM_207413	NP_997296	Q6UXT8	F150A_HUMAN	hypothetical protein LOC389658 precursor	106						extracellular region					0		Lung NSC(129;0.0919)|all_epithelial(80;0.125)|all_lung(136;0.17)				CAAGCTGGCGTTGAGCACTCC	0.388													39	30					0	0	0	0	C	53452400	C	C	53452400	3	2	301	1	0	0	0	0	1	0	0	0	5484	1725	60	5	81	5	FAM150A	8	53452400	Missense_Mutation	SNP	T	TCGA-HD-7832-01A-11D-2129-08		53452400	92911622	45	55379											
CHD7	55636	broad.mit.edu	37	chr8	61765709	61765709	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aggggcaggtaatacatcttCcttgaacccactggcagttg	10	10	11	10	0	1	1	0	1	1	0	2	1	2	1	2	4	2	4	2	4	3	5			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr8:61765709C>T	uc003xue.2	+	31	6902	c.6425C>T	c.(6424-6426)TCC>TTC	p.S2142F		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2142					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AATACATCTTCCTTGAACCCA	0.463													29	19					0	0	0	0	T	61765709	T	T	61765709	3	4	301	1	0	0	0	0	1	0	0	0	3345	855	30	2	6543	2	CHD7	8	61765709	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	8313309	61765709	84598313	46	55380											
FABP9	646480	broad.mit.edu	37	chr8	82373746	82373746	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cagcttccaggttcccaagaAgggctcaaccatcatggaac	12	7	9	13	0	2	1	2	0	0	1	4	2	4	2	3	3	3	3	3	3	4	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr8:82373746A>G	uc011lfo.1	-	1	13	c.13T>C	c.(13-15)TTC>CTC	p.F5L		NM_001080526	NP_001073995	Q0Z7S8	FABP9_HUMAN	fatty acid binding protein 9, testis	5							lipid binding|transporter activity				0			Epithelial(68;0.186)			GTTCCCAAGAAGGGCTCAACC	0.403													42	147					0	0	0	0	G	82373746	G	G	82373746	3	3	301	1	0	0	0	0	1	0	0	0	5391	72	3	5	400	5	FABP9	8	82373746	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08	20608037	82373746	63990276	47	55381											
ASAP1	50807	broad.mit.edu	37	chr8	131172152	131172152	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accccttcttttcactgccaTattccttattgccctggagc	6	15	5	15	0	2	0	1	0	1	0	3	1	3	1	5	1	3	0	5	1	2	7			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr8:131172152T>C	uc003yta.1	-	11	996	c.968A>G	c.(967-969)TAT>TGT	p.Y323C	ASAP1_uc003ysz.1_Missense_Mutation_p.Y134C|ASAP1_uc011liw.1_Missense_Mutation_p.Y316C	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	323					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TTCACTGCCATATTCCTTATT	0.438													168	123					0	0	0	0	C	131172152	C	C	131172152	3	2	301	1	0	0	0	0	1	0	0	0	1012	1406	49	5	2497	5	ASAP1	8	131172152	Missense_Mutation	SNP	T	TCGA-HD-7832-01A-11D-2129-08	48798406	131172152	15191870	48	55382											
PTK2	5747	broad.mit.edu	37	chr8	141900671	141900671	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	agtagcatctccatgcctgaTaatactggcccaggtggttg	9	11	11	10	0	1	1	0	1	1	0	2	1	1	1	3	3	3	3	3	3	3	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr8:141900671T>C	uc003yvu.2	-	3	396	c.166A>G	c.(166-168)ATC>GTC	p.I56V	PTK2_uc003yvs.2_Missense_Mutation_p.I56V|PTK2_uc003yvt.2_Missense_Mutation_p.I78V|PTK2_uc003yvv.2_5'UTR|PTK2_uc011ljr.1_Missense_Mutation_p.I56V	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	56	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			CCATGCCTGATAATACTGGCC	0.393													29	104					0	0	0	0	C	141900671	C	C	141900671	3	2	301	1	0	0	0	0	1	0	0	0	12825	1406	49	5	3112	5	PTK2	8	141900671	Missense_Mutation	SNP	T	TCGA-HD-7832-01A-11D-2129-08	10728519	141900671	4463351	49	55383											
C9orf5	23731	broad.mit.edu	37	chr9	111853316	111853316	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actagttttcttctttctaaGaaacgttcctatttcaggcc	9	17	5	10	1	4	1	1	0	3	1	5	1	5	1	2	1	1	2	2	1	4	9			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr9:111853316G>A	uc004bdt.3	-	5	1068	c.1036C>T	c.(1036-1038)CTT>TTT	p.L346F	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Missense_Mutation_p.L346F	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	346						integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		TTCTTTCTAAGAAACGTTCCT	0.507													13	127					0	0	0	0	A	111853316	A	A	111853316	3	1	301	1	0	0	0	0	1	0	0	0	2498	942	33	2	1659	2	C9orf5	9	111853316	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08		111853316	29360115	50	55384											
C9orf119	375757	broad.mit.edu	37	chr9	131038579	131038579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacactccgggtcagagttcCtggcccggtgcacctgagag	7	7	13	14	2	1	2	1	1	0	2	3	3	3	2	4	3	1	2	4	3	0	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr9:131038579C>T	uc004bup.2	+	1	155	c.155C>T	c.(154-156)CCT>CTT	p.P52L	GOLGA2_uc011maw.1_5'Flank|GOLGA2_uc010mxw.2_5'Flank|GOLGA2_uc004bul.1_5'Flank|C9orf119_uc010mxx.1_Missense_Mutation_p.P52L	NM_001040011	NP_001035100	Q1ZZU3	SWI5_HUMAN	hypothetical protein LOC375757	52					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0						GTCAGAGTTCCTGGCCCGGTG	0.701													7	32					0	0	0	0	T	131038579	T	T	131038579	3	4	301	1	0	0	0	0	1	0	0	0	2464	681	24	4	157	4	C9orf119	9	131038579	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	19185263	131038579	10174852	51	55385											
OLAH	55301	broad.mit.edu	37	chr10	15107610	15107610	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctggcatcgcattcccaaaGatgatgaattgtcagaagaa	14	9	9	9	1	1	5	1	2	0	3	3	5	2	5	2	1	0	2	2	1	4	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr10:15107610G>T	uc001inu.2	+	6	684	c.430G>T	c.(430-432)GAT>TAT	p.D144Y	ACBD7_uc010qby.1_Intron|OLAH_uc001int.2_Missense_Mutation_p.D197Y	NM_001039702	NP_001034791	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase isoform 2	144					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity				0						CATTCCCAAAGATGATGAATT	0.393													23	33					2.48779e-11	2.63632e-11	1	0	T	15107610	T	T	15107610	3	4	301	1	0	0	0	0	1	0	0	0	10905	942	33	2	611	2	OLAH	10	15107610	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08		15107610	120427137	52	55386											
GPR158	57512	broad.mit.edu	37	chr10	25886968	25886968	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acacagggaaatccaaggagGagaccctgaaaaaccgagtc	17	3	11	10	1	0	2	0	1	0	1	2	6	1	4	3	3	1	0	3	3	4	0			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr10:25886968G>A	uc001isj.2	+	11	2473	c.2413G>A	c.(2413-2415)GAG>AAG	p.E805K	GPR158_uc001isk.2_Missense_Mutation_p.E180K	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	805	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						ATCCAAGGAGGAGACCCTGAA	0.542													31	52					0	0	0	0	A	25886968	A	A	25886968	3	1	301	1	0	0	0	0	1	0	0	0	6701	1175	41	2	2455	2	GPR158	10	25886968	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	10779358	25886968	109647779	53	55387											
SUPV3L1	6832	broad.mit.edu	37	chr10	70940081	70940081	+	Frame_Shift_Del	DEL	C	-	-																															gtgccctattgtgggctcggCtcccggcggggcgccaggct																										TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr10:70940081delC	uc001jpe.1	+	1	89	c.34delC	c.(34-36)CTCfs	p.L12fs	SUPV3L1_uc010qjd.1_5'UTR	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	12					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						GTGGGCTCGGCTCCCGGCGGG	0.687													---	---	---								-	70940081	-	-	70940081	7	5	301	1	0	1	0	1	0	0	0	0	15468	797	28	0	36	0	SUPV3L1	10	70940081	Frame_Shift_Del	DEL	C	TCGA-HD-7832-01A-11D-2129-08	45053113	70940081	64594666	54	55388											
TIAL1	7073	broad.mit.edu	37	chr10	121341997	121341998	+	In_Frame_Ins	INS	-	AGCAGCTAATGC	AGCAGCTAATGC																															aaaatttttctcccattcatINSagcagctaatgcagcagctg																										TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr10:121341997_121341998insAGCAGCTAATGC	uc001lei.1	-	3	765_766	c.201_202insGCATTAGCTGCT	c.(199-204)insGCATTAGCTGCT	p.67_68insALAA	TIAL1_uc001leh.1_In_Frame_Ins_p.45_46insALAA|TIAL1_uc001lej.1_In_Frame_Ins_p.84_85insALAA|TIAL1_uc001lek.1_Translation_Start_Site|TIAL1_uc009xzi.1_Intron|TIAL1_uc010qtb.1_Translation_Start_Site	NM_003252	NP_003243	Q01085	TIAR_HUMAN	TIA-1 related protein isoform 1	67_68	RRM 1.				apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		CTCCCATTCATAGCAGCTAATG	0.371													---	---	---								AGCAGCTAATGC	121341998	AGCAGCTAATGC	AGCAGCTAATGC	121341997	7	5	301	1	0	1	1	0	0	0	0	0	15955	1406	49	0	965	0	TIAL1	10	121341997	In_Frame_Ins	INS	-	TCGA-HD-7832-01A-11D-2129-08	50401916	121341997	14192750	55	55389											
INPP5F	22876	broad.mit.edu	37	chr10	121563719	121563721	+	In_Frame_Del	DEL	AGA	-	-																															ggtagaccaggcaggaagagAgaagattattggcgatgctt																										TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr10:121563719_121563721delAGA	uc001leo.2	+	10	1317_1319	c.1151_1153delAGA	c.(1150-1155)GAGAAG>GAG	p.K385del		NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	385	SAC.						phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		GCAGGAAGAGAGAAGATTATTGG	0.36													---	---	---								-	121563721	-	-	121563719	7	5	301	1	0	1	0	1	0	0	0	0	7797	304	11	0	1189	0	INPP5F	10	121563719	In_Frame_Del	DEL	AGA	TCGA-HD-7832-01A-11D-2129-08	221722	121563719	13971028	56	55390											
UROS	7390	broad.mit.edu	37	chr10	127496033	127496033	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttccacaggtttctccttCtgtatccaggccaattttac	8	16	5	12	0	2	0	0	0	2	0	5	0	4	0	4	2	1	2	4	2	3	6			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr10:127496033C>T	uc001liw.3	-	5	476	c.343G>A	c.(343-345)GAA>AAA	p.E115K	UROS_uc001liv.3_5'UTR|UROS_uc010quh.1_RNA|UROS_uc001lix.3_Missense_Mutation_p.E115K|UROS_uc001liy.3_RNA|UROS_uc001liz.2_RNA	NM_000375	NP_000366	P10746	HEM4_HUMAN	uroporphyrinogen III synthase	115					heme biosynthetic process|uroporphyrinogen III biosynthetic process	cytosol|mitochondrion	uroporphyrinogen-III synthase activity				0		all_lung(145;0.00756)|Lung NSC(174;0.0116)|Colorectal(57;0.0855)|all_neural(114;0.0937)|Breast(234;0.203)				GTTTCTCCTTCTGTATCCAGG	0.353													14	43					0	0	0	0	T	127496033	T	T	127496033	3	4	301	1	0	0	0	0	1	0	0	0	17098	922	32	2	474	2	UROS	10	127496033	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	5932314	127496033	8038714	57	55391											
STK32C	282974	broad.mit.edu	37	chr10	134036234	134036234	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggcctggactccaggatcaTctcctccagctcaaaggtgg	8	8	12	13	0	3	0	2	0	1	0	6	2	5	2	4	5	1	1	4	5	1	0			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr10:134036234T>A	uc001lle.1	-	10	1302	c.1162A>T	c.(1162-1164)ATG>TTG	p.M388L	STK32C_uc001lld.1_Missense_Mutation_p.M271L|STK32C_uc010quu.1_Missense_Mutation_p.M401L|STK32C_uc001llb.2_Missense_Mutation_p.M159L|STK32C_uc001llc.1_RNA	NM_173575	NP_775846	Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	388							ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|breast(1)	5		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		TCCAGGATCATCTCCTCCAGC	0.627													7	6					0	0	0	0	A	134036234	A	A	134036234	3	1	301	1	0	0	0	0	1	0	0	0	15365	1435	50	5	310	5	STK32C	10	134036234	Missense_Mutation	SNP	T	TCGA-HD-7832-01A-11D-2129-08	6540201	134036234	1498513	58	55392											
PHRF1	57661	broad.mit.edu	37	chr11	611008	611008	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggaggaggtgaagctggccAtcaagcccttctaccagaag	11	7	13	10	0	2	2	1	1	1	1	2	4	2	4	3	4	3	1	3	4	4	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr11:611008A>T	uc001lqe.2	+	17	4863	c.4732A>T	c.(4732-4734)ATC>TTC	p.I1578F	PHRF1_uc010qwc.1_Missense_Mutation_p.I1577F|PHRF1_uc010qwd.1_Missense_Mutation_p.I1576F|PHRF1_uc010qwe.1_Missense_Mutation_p.I1574F|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1578	Potential.						RNA polymerase binding|zinc ion binding				0						GAAGCTGGCCATCAAGCCCTT	0.592													9	17					0	0	0	0	T	611008	T	T	611008	3	4	301	1	0	0	0	0	1	0	0	0	11916	217	8	5	4791	5	PHRF1	11	611008	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08		611008	134395508	59	55393											
IGF2	3481	broad.mit.edu	37	chr11	2154782	2154782	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggggtcgacacgtccctctCggacttggcgggggtagcac	6	7	16	12	4	1	0	0	0	1	0	4	2	2	1	1	6	1	2	1	6	1	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr11:2154782C>T	uc009yde.2	-	3	374	c.271G>A	c.(271-273)GAG>AAG	p.E91K	IGF2_uc001lvf.2_RNA|IGF2_uc001lvg.2_Missense_Mutation_p.E91K|IGF2_uc009ydf.2_Missense_Mutation_p.E147K|IGF2_uc001lvh.2_Missense_Mutation_p.E91K|INS-IGF2_uc001lvi.2_RNA	NM_001007139	NP_001007140	P01344	IGF2_HUMAN	insulin-like growth factor 2 isoform 1	91	D.				glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)	1		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		ACGTCCCTCTCGGACTTGGCG	0.652													15	15					0	0	0	0	T	2154782	T	T	2154782	3	4	301	1	0	0	0	0	1	0	0	0	7611	893	31	1	279	1	IGF2	11	2154782	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	1543774	2154782	132851734	60	55394											
OR8K3	219473	broad.mit.edu	37	chr11	56085986	56085986	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttctcagacatctggctttCatggatcttggttattcaac	8	17	7	9	0	5	1	3	0	3	1	6	2	5	2	0	3	1	2	0	3	2	5			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr11:56085986C>T	uc010rjf.1	+	1	204	c.204C>T	c.(202-204)TTC>TTT	p.F68F		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					ATCTGGCTTTCATGGATCTTG	0.383													43	87					0	0	0	0	T	56085986	T	T	56085986	2	4	301	1	0	0	0	0	0	0	0	1	11298	825	29	2		2	OR8K3	11	56085986	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08	53931204	56085986	78920530	61	55395											
TSGA10IP	254187	broad.mit.edu	37	chr11	65714808	65714808	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaggcgcaaaacctgaaggCgagacagcagctgggagcct	13	3	15	10	2	0	3	0	1	0	2	0	5	0	4	2	3	4	3	2	3	3	0			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr11:65714808C>T	uc001ogk.1	+	5	544	c.512C>T	c.(511-513)GCG>GTG	p.A171V	TSGA10IP_uc009yqw.1_RNA|TSGA10IP_uc009yqx.1_Intron	NM_152762	NP_689975	Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein	171											0						AACCTGAAGGCGAGACAGCAG	0.652													5	14					0	0	0	0	T	65714808	T	T	65714808	3	4	301	1	0	0	0	0	1	0	0	0	16685	768	27	1	522	1	TSGA10IP	11	65714808	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	9628822	65714808	69291708	62	55396											
CNTN5	53942	broad.mit.edu	37	chr11	100141898	100141898	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctgggtggaatatgaatttCgagtggtagccaccaaccct	10	10	11	10	1	0	1	0	1	0	0	1	3	0	2	4	3	2	1	4	3	5	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr11:100141898C>T	uc001pga.2	+	18	2578	c.2239C>T	c.(2239-2241)CGA>TGA	p.R747*	CNTN5_uc001pfz.2_Nonsense_Mutation_p.R747*|CNTN5_uc001pgb.2_Nonsense_Mutation_p.R673*|CNTN5_uc010ruk.1_Nonsense_Mutation_p.R18*	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	747	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ATATGAATTTCGAGTGGTAGC	0.458													10	30					0	0	0	0	T	100141898	T	T	100141898	4	4	301	1	0	0	0	0	0	1	0	0	3659	876	31	1	2301	1	CNTN5	11	100141898	Nonsense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	34427090	100141898	34864618	63	55397											
GRAMD1B	57476	broad.mit.edu	37	chr11	123471189	123471189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aatctagcacttcttcacttCgtttggggcccgggatagga	8	12	11	10	2	3	0	1	0	2	0	4	2	3	2	1	4	1	2	1	4	3	6			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr11:123471189C>T	uc001pyx.2	+	7	883	c.554C>T	c.(553-555)TCG>TTG	p.S185L	GRAMD1B_uc001pyw.2_Missense_Mutation_p.S192L|GRAMD1B_uc010rzw.1_Missense_Mutation_p.S145L|GRAMD1B_uc010rzx.1_Missense_Mutation_p.S145L|GRAMD1B_uc009zbe.1_Missense_Mutation_p.S181L	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	185						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		TTCTTCACTTCGTTTGGGGCC	0.408													12	20					0	0	0	0	T	123471189	T	T	123471189	3	4	301	1	0	0	0	0	1	0	0	0	6787	893	31	1	580	1	GRAMD1B	11	123471189	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	23329291	123471189	11535327	64	55398											
A2M	2	broad.mit.edu	37	chr12	9265043	9265043	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgtcctcgttcttaaccatCactgtggtccgcttcttaaa	7	15	6	13	2	3	0	1	0	2	0	6	0	5	0	3	1	1	2	3	1	3	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr12:9265043C>T	uc001qvk.1	-	3	473	c.360G>A	c.(358-360)GTG>GTA	p.V120V	A2M_uc009zgk.1_Intron	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	120					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TCTTAACCATCACTGTGGTCC	0.453													15	22					0	0	0	0	T	9265043	T	T	9265043	2	4	301	1	0	0	0	0	0	0	0	1	4	813	29	2		2	A2M	12	9265043	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08		9265043	124586852	65	55399											
SLC2A13	114134	broad.mit.edu	37	chr12	40158310	40158310	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	taaaaatgttagtgaaaccaGgacattgaaaatccagttta	18	11	7	5	0	0	2	0	2	0	0	1	3	1	3	2	1	1	2	2	1	8	5			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr12:40158310G>A	uc010skm.1	-	9	1723	c.1672C>T	c.(1672-1674)CTG>TTG	p.L558L	C12orf40_uc009zjv.1_Intron	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	558	Helical; Name=11; (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				AGTGAAACCAGGACATTGAAA	0.328										HNSCC(50;0.14)			26	63					0	0	0	0	A	40158310	A	A	40158310	2	1	301	1	0	0	0	0	0	0	0	1	14606	991	35	4		4	SLC2A13	12	40158310	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08	30893267	40158310	93693585	66	55400											
LRRK2	120892	broad.mit.edu	37	chr12	40758787	40758787	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actcctggatctttcaactcGtcgacttatacgtgtaattt	9	16	6	10	3	2	0	1	0	1	0	5	2	3	1	1	1	2	1	1	1	4	5			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr12:40758787G>A	uc001rmg.3	+	49	7446	c.7325G>A	c.(7324-7326)CGT>CAT	p.R2442H	LRRK2_uc009zjw.2_Missense_Mutation_p.R1280H|LRRK2_uc001rmi.2_Missense_Mutation_p.R1275H	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2442					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTTTCAACTCGTCGACTTATA	0.398											OREG0003828	type=REGULATORY REGION|Gene=LRRK2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	26	42					0	0	0	0	A	40758787	A	A	40758787	3	1	301	1	0	0	0	0	1	0	0	0	9083	1145	40	1	7519	1	LRRK2	12	40758787	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	600477	40758787	93093108	67	55401											
HOXC9	3225	broad.mit.edu	37	chr12	54396311	54396311	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaactggagaaggagtttctCttcaatatgtatttaaccag	13	13	9	6	0	2	1	1	0	1	1	3	4	2	2	1	2	2	2	1	2	6	6			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr12:54396311C>T	uc001sep.2	+	3	734	c.636C>T	c.(634-636)CTC>CTT	p.L212L	HOXC9_uc001seq.2_Silent_p.L212L	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	212	Homeobox.				multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						AGGAGTTTCTCTTCAATATGT	0.547													25	56					0	0	0	0	T	54396311	T	T	54396311	2	4	301	1	0	0	0	0	0	0	0	1	7356	900	32	2		2	HOXC9	12	54396311	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08	13637524	54396311	79455584	68	55402											
ERBB3	2065	broad.mit.edu	37	chr12	56495083	56495083	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gactcctgttaccccactctCcccacccgggttagaggaag	8	8	9	16	1	1	1	0	0	1	1	3	3	2	2	6	2	1	2	6	2	3	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr12:56495083C>T	uc001sjh.2	+	27	3633	c.3440C>T	c.(3439-3441)TCC>TTC	p.S1147F	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Missense_Mutation_p.S504F|ERBB3_uc010sqc.1_Missense_Mutation_p.S1088F|ERBB3_uc009zok.2_Missense_Mutation_p.S412F|ERBB3_uc001sjk.2_Missense_Mutation_p.S388F|ERBB3_uc001sjl.2_Missense_Mutation_p.S267F	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	1147	Cytoplasmic (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			ACCCCACTCTCCCCACCCGGG	0.572													22	35					0	0	0	0	T	56495083	T	T	56495083	3	4	301	1	0	0	0	0	1	0	0	0	5232	855	30	2	3677	2	ERBB3	12	56495083	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	2098772	56495083	77356812	69	55403											
AVPR1A	552	broad.mit.edu	37	chr12	63544545	63544545	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccggcttgtgttgccagcGccggtggccagaggccacca	5	7	14	15	3	0	1	0	0	0	1	1	1	1	1	6	4	2	2	6	4	0	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr12:63544545G>A	uc001sro.1	-	1	2046	c.72C>T	c.(70-72)GGC>GGT	p.G24G		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	24	Extracellular (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	TGTTGCCAGCGCCGGTGGCCA	0.711													15	28					0	0	0	0	A	63544545	A	A	63544545	2	1	301	1	0	0	0	0	0	0	0	1	1233	1074	38	1		1	AVPR1A	12	63544545	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08	7049462	63544545	70307350	70	55404											
PPFIA2	8499	broad.mit.edu	37	chr12	81746976	81746976	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcggaatgaccacttggaGagagaagatccattgagcta	14	8	11	8	1	0	5	0	2	0	3	2	8	1	6	2	2	1	1	2	2	3	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr12:81746976G>C	uc001szo.1	-	17	2077	c.1916C>G	c.(1915-1917)TCT>TGT	p.S639C	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	565										ovary(3)|lung(2)|pancreas(1)	6						ACCACTTGGAGAGAGAAGATC	0.408													28	51					0	0	0	0	C	81746976	C	C	81746976	3	2	301	1	0	0	0	0	1	0	0	0	12365	942	33	2	1921	2	PPFIA2	12	81746976	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	18202431	81746976	52104919	71	55405											
WSCD2	9671	broad.mit.edu	37	chr12	108604016	108604016	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaagggcgagcgaggcagcGtgtgcggcggcgccaaccgc	7	2	19	13	7	0	0	0	0	0	0	0	2	0	0	2	4	4	2	2	4	2	0			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr12:108604016G>A	uc001tms.2	+	4	1360	c.616G>A	c.(616-618)GTG>ATG	p.V206M	WSCD2_uc001tmt.2_Missense_Mutation_p.V206M	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	206	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GCGAGGCAGCGTGTGCGGCGG	0.682													7	10					0	0	0	0	A	108604016	A	A	108604016	3	1	301	1	0	0	0	0	1	0	0	0	17475	1145	40	1	626	1	WSCD2	12	108604016	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	26857040	108604016	25247879	72	55406											
SLITRK5	26050	broad.mit.edu	37	chr13	88329719	88329719	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgctggtcatgaagcgcagGaagaagaaccagagcgacca	14	4	14	9	2	1	4	1	1	0	3	1	6	1	5	2	2	4	2	2	2	4	0			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr13:88329719G>A	uc001vln.2	+	2	2295	c.2076G>A	c.(2074-2076)AGG>AGA	p.R692R	SLITRK5_uc010tic.1_Silent_p.R451R	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	692	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TGAAGCGCAGGAAGAAGAACC	0.607													6	47					0	0	0	0	A	88329719	A	A	88329719	2	1	301	1	0	0	0	0	0	0	0	1	14810	1165	41	2		2	SLITRK5	13	88329719	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08		88329719	26840159	73	55407											
MCF2L	23263	broad.mit.edu	37	chr13	113730378	113730378	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaggctgccctccaggaaatCgagaagtttttggagaccgg	10	8	14	9	2	0	2	0	0	0	2	2	6	1	3	3	4	1	2	3	4	2	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr13:113730378C>T	uc001vsu.2	+	12	1600	c.1578C>T	c.(1576-1578)ATC>ATT	p.I526I	MCF2L_uc001vsq.2_Silent_p.I526I|MCF2L_uc010tjr.1_Silent_p.I469I|MCF2L_uc001vsr.2_Silent_p.I473I|MCF2L_uc001vss.3_Silent_p.I467I|MCF2L_uc010tjs.1_Silent_p.I467I|MCF2L_uc001vst.1_Silent_p.I431I	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	499					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TCCAGGAAATCGAGAAGTTTT	0.522													16	34					0	0	0	0	T	113730378	T	T	113730378	2	4	301	1	0	0	0	0	0	0	0	1	9432	874	31	1		1	MCF2L	13	113730378	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08	25400659	113730378	1439500	74	55408											
DHRS2	10202	broad.mit.edu	37	chr14	24114424	24114424	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	atgccagctacgtcaacgggGagaacattgcggtggcaggc	10	6	15	10	3	1	1	1	0	0	1	1	2	1	1	1	5	6	2	1	5	3	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr14:24114424G>A	uc001wkt.3	+	9	1263	c.816G>A	c.(814-816)GGG>GGA	p.G272G	DHRS2_uc001wku.3_Missense_Mutation_p.E269K|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Missense_Mutation_p.G270E	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	Error:Variant_position_missing_in_Q13268_after_alignment					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity	p.A272V(1)		large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		CGTCAACGGGGAGAACATTGC	0.607													46	68					0	0	0	0	A	24114424	A	A	24114424	2	1	301	1	0	0	0	0	0	0	0	1	4512	1175	41	2		2	DHRS2	14	24114424	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08		24114424	83235116	75	55409											
AKAP6	9472	broad.mit.edu	37	chr14	33291093	33291093	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catggaggagacatgagccaGaattcaggcagtgagagtgg	13	6	16	6	0	1	4	1	2	0	3	1	7	1	5	1	4	1	1	1	4	1	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr14:33291093G>C	uc001wrq.2	+	13	4244	c.4074G>C	c.(4072-4074)CAG>CAC	p.Q1358H		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1358					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ACATGAGCCAGAATTCAGGCA	0.458													14	46					0	0	0	0	C	33291093	C	C	33291093	3	2	301	1	0	0	0	0	1	0	0	0	455	933	33	2	4120	2	AKAP6	14	33291093	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	9176669	33291093	74058447	76	55410											
MDGA2	161357	broad.mit.edu	37	chr14	47601019	47601019	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcatagtcctgaggtcgaaGattctttagttttaagatct	11	15	9	6	1	2	3	0	1	2	2	4	4	3	3	1	1	1	2	1	1	4	6			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr14:47601019G>T	uc001wwj.3	-	5	812	c.616C>A	c.(616-618)CTT>ATT	p.L206I	MDGA2_uc001wwi.3_5'UTR|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	206	Ig-like 2.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TGAGGTCGAAGATTCTTTAGT	0.323													13	19					1.61879e-10	1.70273e-10	1	0	T	47601019	T	T	47601019	3	4	301	1	0	0	0	0	1	0	0	0	9460	942	33	2	2306	2	MDGA2	14	47601019	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	14309926	47601019	59748521	77	55411											
ENTPD5	957	broad.mit.edu	37	chr14	74440678	74440678	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggaaagtgtgcccatcaGtccctgaaagaatccagggc	11	7	11	12	1	1	2	1	1	0	1	4	3	4	3	4	2	1	0	4	2	3	0			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr14:74440678G>C	uc010tuo.1	-	12	1099	c.788C>G	c.(787-789)ACT>AGT	p.T263S	ENTPD5_uc001xpi.2_Missense_Mutation_p.T263S	NM_001249	NP_001240	O75356	ENTP5_HUMAN	ectonucleoside triphosphate diphosphohydrolase 5	263					'de novo' posttranslational protein folding|ATP metabolic process|cell growth|cell proliferation|glycolysis|protein N-linked glycosylation|regulation of phosphatidylinositol 3-kinase cascade	endoplasmic reticulum lumen	guanosine-diphosphatase activity|uridine-diphosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00394)		GTGCCCATCAGTCCCTGAAAG	0.512													31	60					0	0	0	0	C	74440678	C	C	74440678	3	2	301	1	0	0	0	0	1	0	0	0	5166	1029	36	4	518	4	ENTPD5	14	74440678	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	26839659	74440678	32908862	78	55412											
RYR3	6263	broad.mit.edu	37	chr15	33927847	33927847	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggagaaggtcagcatagacAagatccgatttttccgggta	12	10	12	7	2	1	3	1	0	0	3	3	5	3	3	2	3	1	2	2	3	4	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr15:33927847A>G	uc001zhi.2	+	26	3278	c.3208A>G	c.(3208-3210)AAG>GAG	p.K1070E	RYR3_uc010bar.2_Missense_Mutation_p.K1070E	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1070	B30.2/SPRY 2.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGCATAGACAAGATCCGATT	0.473													9	19					0	0	0	0	G	33927847	G	G	33927847	3	3	301	1	0	0	0	0	1	0	0	0	13835	131	5	5	3310	5	RYR3	15	33927847	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08		33927847	68603545	79	55413											
UNC13C	440279	broad.mit.edu	37	chr15	54527261	54527261	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctttatggtattgacagcatGccggatcttcgcagaaaaaa	13	11	9	8	2	1	2	0	1	1	1	2	3	1	3	1	2	2	3	1	2	5	5			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr15:54527261G>A	uc002ack.2	+	4	3105	c.3105G>A	c.(3103-3105)ATG>ATA	p.M1035I		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1035					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TTGACAGCATGCCGGATCTTC	0.373													10	27					0	0	0	0	A	54527261	A	A	54527261	3	1	301	1	0	0	0	0	1	0	0	0	17054	1319	46	4	3119	4	UNC13C	15	54527261	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	20599414	54527261	48004131	80	55414											
CSPG4	1464	broad.mit.edu	37	chr15	75974679	75974679	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gcctcccctgtgctgtcctgCtgggcgtggaacagccggcc	3	8	14	16	2	0	0	0	0	0	0	2	1	2	1	6	3	4	2	6	3	1	0	rs145039359		TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr15:75974679C>T	uc002baw.2	-	8	4998	c.4905G>A	c.(4903-4905)CAG>CAA	p.Q1635Q		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1635	Extracellular (Potential).|Cysteine-containing.|Neurite growth inhibition (By similarity).|CSPG 11.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						TGCTGTCCTGCTGGGCGTGGA	0.677													27	54					0	0	0	0	T	75974679	T	T	75974679	2	4	301	1	0	0	0	0	0	0	0	1	3977	796	28	4		4	CSPG4	15	75974679	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08	21447418	75974679	26556713	81	55415											
KIAA0556	23247	broad.mit.edu	37	chr16	27761517	27761517	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatcagaatttggaactacaAtaaatctcggatacattcct	15	12	6	8	1	2	1	1	0	1	1	4	4	3	3	1	2	3	0	1	2	7	5			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr16:27761517A>G	uc002dow.2	+	16	3260	c.3236A>G	c.(3235-3237)AAT>AGT	p.N1079S		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1079										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TGGAACTACAATAAATCTCGG	0.527													28	48					0	0	0	0	G	27761517	G	G	27761517	3	3	301	1	0	0	0	0	1	0	0	0	8222	101	4	5	3298	5	KIAA0556	16	27761517	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08		27761517	62593236	82	55416											
CNTROB	116840	broad.mit.edu	37	chr17	7847852	7847852	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gtgggaaccagcagctggagGagcagcgggtggagctggtg	8	5	21	7	1	0	0	0	0	0	0	0	4	0	4	1	6	6	4	1	6	1	0			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr17:7847852G>A	uc002gjq.2	+	13	2549	c.1630G>A	c.(1630-1632)GAG>AAG	p.E544K	CNTROB_uc002gjp.2_Missense_Mutation_p.E544K|CNTROB_uc002gjr.2_Missense_Mutation_p.E446K	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	544	Potential.|Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				GCAGCTGGAGGAGCAGCGGGT	0.622													24	34					0	0	0	0	A	7847852	A	A	7847852	3	1	301	1	0	0	0	0	1	0	0	0	3666	1175	41	2	1676	2	CNTROB	17	7847852	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08		7847852	73347358	83	55417											
ARHGEF15	22899	broad.mit.edu	37	chr17	8215869	8215869	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ggctcaggatgcagatgcccCggagccaggtctccaagcga	9	5	14	13	2	2	1	1	0	1	1	3	4	2	3	4	4	4	2	4	4	1	0	rs147736312		TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr17:8215869C>A	uc002glc.2	+	2	633	c.512C>A	c.(511-513)CCG>CAG	p.P171Q	ARHGEF15_uc002glb.1_Missense_Mutation_p.P171Q|ARHGEF15_uc002gld.2_Missense_Mutation_p.P171Q|ARHGEF15_uc010vuw.1_Missense_Mutation_p.P171Q	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	171					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GCAGATGCCCCGGAGCCAGGT	0.642													20	44					6.21321e-17	6.68391e-17	1	0	A	8215869	A	A	8215869	3	1	301	1	0	0	0	0	1	0	0	0	898	652	23	3	514	3	ARHGEF15	17	8215869	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	368017	8215869	72979341	84	55418											
MYH10	4628	broad.mit.edu	37	chr17	8411915	8411915	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcttgcttattcctgattttGgccaagtttttcgccttttc	4	21	6	10	1	1	1	0	1	1	0	4	1	2	1	3	1	1	2	3	1	2	9			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr17:8411915G>A	uc002gll.2	-	24	3174	c.3078C>T	c.(3076-3078)GCC>GCT	p.A1026A	MYH10_uc002glm.2_Silent_p.A1057A|MYH10_uc010cnx.2_Silent_p.A1035A	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1026	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TCCTGATTTTGGCCAAGTTTT	0.413													69	124					0	0	0	0	A	8411915	A	A	8411915	2	1	301	1	0	0	0	0	0	0	0	1	10083	1335	47	4		4	MYH10	17	8411915	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08	196046	8411915	72783295	85	55419											
PIK3R6	146850	broad.mit.edu	37	chr17	8730512	8730512	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcagccagcttgtggatggCggggcacagcgtgttgacgt	6	9	16	10	3	1	1	1	1	0	0	1	2	1	2	1	4	3	3	1	4	0	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr17:8730512C>T	uc002glq.1	-	13	1732	c.1492G>A	c.(1492-1494)GCC>ACC	p.A498T	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	498					platelet activation	cytosol					0						TTGTGGATGGCGGGGCACAGC	0.662													6	9					0	0	0	0	T	8730512	T	T	8730512	3	4	301	1	0	0	0	0	1	0	0	0	11978	768	27	1	803	1	PIK3R6	17	8730512	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	318597	8730512	72464698	86	55420											
PLEKHM1	9842	broad.mit.edu	37	chr17	43545614	43545614	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actaccagcttcagaccagcTccgtcatgagcctgggcctt	8	9	9	15	1	2	2	2	1	0	1	3	2	3	2	5	1	4	2	5	1	1	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr17:43545614T>A	uc002ija.2	-	5	1439	c.1269A>T	c.(1267-1269)GGA>GGT	p.G423G	PLEKHM1_uc010wjm.1_Silent_p.G395G|PLEKHM1_uc002ijb.2_Intron|PLEKHM1_uc010wjn.1_Silent_p.G372G	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	423					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					TCAGACCAGCTCCGTCATGAG	0.587													4	18					0	0	0	0	A	43545614	A	A	43545614	2	1	301	1	0	0	0	0	0	0	0	1	12135	1538	54	5		5	PLEKHM1	17	43545614	Silent	SNP	T	TCGA-HD-7832-01A-11D-2129-08	34815102	43545614	37649596	87	55421											
OTOP2	92736	broad.mit.edu	37	chr17	72923778	72923778	+	Silent	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggtgtggtctcatgttcacActcaccaccaacctggccat	9	10	8	14	0	3	0	3	0	1	0	4	0	3	0	4	3	1	1	4	3	1	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr17:72923778A>T	uc010wrp.1	+	6	617	c.528A>T	c.(526-528)ACA>ACT	p.T176T	OTOP2_uc002jmf.1_3'UTR	NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	176						integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					TCATGTTCACACTCACCACCA	0.582													21	45					0	0	0	0	T	72923778	T	T	72923778	2	4	301	1	0	0	0	0	0	0	0	1	11360	146	6	5		5	OTOP2	17	72923778	Silent	SNP	A	TCGA-HD-7832-01A-11D-2129-08	29378164	72923778	8271432	88	55422											
NPLOC4	55666	broad.mit.edu	37	chr17	79532588	79532588	+	Frame_Shift_Del	DEL	C	-	-																															cttccatgtctgggcgagctCctcatttctggtccgcacgg																										TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr17:79532588delC	uc002kat.3	-	16	1794	c.1612delG	c.(1612-1614)GAGfs	p.E538fs	NPLOC4_uc002kau.3_Frame_Shift_Del_p.E538fs|NPLOC4_uc010wur.1_Frame_Shift_Del_p.E377fs|NPLOC4_uc002kar.2_5'Flank|NPLOC4_uc010dic.2_RNA|NPLOC4_uc002kas.2_Frame_Shift_Del_p.R61fs	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	538					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TGGGCGAGCTCCTCATTTCTG	0.622													---	---	---								-	79532588	-	-	79532588	7	5	301	1	0	1	0	1	0	0	0	0	10640	864	30	0	222	0	NPLOC4	17	79532588	Frame_Shift_Del	DEL	C	TCGA-HD-7832-01A-11D-2129-08	6608810	79532588	1662622	89	55423											
CTAGE1	64693	broad.mit.edu	37	chr18	19995819	19995819	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ccagggccagttgcttcattTtcagcggggagagatgaatc	9	10	13	9	1	2	2	2	1	0	1	3	4	2	3	2	3	2	2	2	3	1	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr18:19995819T>C	uc002ktv.1	-	1	2060	c.1956A>G	c.(1954-1956)GAA>GAG	p.E652E		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	652						integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TTGCTTCATTTTCAGCGGGGA	0.438													70	164					0	0	0	0	C	19995819	C	C	19995819	2	2	301	1	0	0	0	0	0	0	0	1	4009	1838	64	5		5	CTAGE1	18	19995819	Silent	SNP	T	TCGA-HD-7832-01A-11D-2129-08		19995819	58081429	90	55424											
DSG1	1828	broad.mit.edu	37	chr18	28919849	28919849	+	Frame_Shift_Del	DEL	T	-	-																															acttcttccactaactatgaTaccagcacaacttctactga																										TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr18:28919849delT	uc002kwp.2	+	11	1760	c.1548delT	c.(1546-1548)GATfs	p.D516fs		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	516	Extracellular (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CTAACTATGATACCAGCACAA	0.398													---	---	---								-	28919849	-	-	28919849	7	5	301	1	0	1	0	1	0	0	0	0	4798	1403	49	0	1590	0	DSG1	18	28919849	Frame_Shift_Del	DEL	T	TCGA-HD-7832-01A-11D-2129-08	8924030	28919849	49157399	91	55425											
MOCOS	55034	broad.mit.edu	37	chr18	33780032	33780032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggttgcaccctgtgagcaCgcctgggaagtggtttgtgc	5	10	16	10	2	0	1	0	1	0	0	0	2	0	2	2	3	3	4	2	3	1	2	rs141623345		TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr18:33780032C>T	uc002kzq.3	+	4	709	c.686C>T	c.(685-687)ACG>ATG	p.T229M		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	229					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	CCTGTGAGCACGCCTGGGAAG	0.567													24	60					0	0	0	0	T	33780032	T	T	33780032	3	4	301	1	0	0	0	0	1	0	0	0	9742	536	19	1	700	1	MOCOS	18	33780032	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	4860183	33780032	44297216	92	55426											
C19orf36	113177	broad.mit.edu	37	chr19	2097286	2097286	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	accaagtggcgacagcagtgTaccagatgatggatcagctg	12	7	13	9	1	1	2	1	1	0	1	1	4	1	3	2	2	3	3	2	2	2	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:2097286T>G	uc002luw.1	+	2	330	c.253T>G	c.(253-255)TAC>GAC	p.Y85D	C19orf36_uc002lux.1_Missense_Mutation_p.Y85D|C19orf36_uc010xgw.1_Missense_Mutation_p.Y85D	NM_001039846	NP_001034935	Q1ZYL8	IZUM4_HUMAN	hypothetical protein LOC113177 isoform 3	85						extracellular region					0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACAGCAGTGTACCAGATGAT	0.697											OREG0025135	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	38					0	0	0	0	G	2097286	G	G	2097286	3	3	301	1	0	0	0	0	1	0	0	0	1930	1638	57	5	259	5	C19orf36	19	2097286	Missense_Mutation	SNP	T	TCGA-HD-7832-01A-11D-2129-08		2097286	57031697	93	55427											
PEX11G	92960	broad.mit.edu	37	chr19	7543261	7543261	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tttcagcagcatccacagggAcctgcagcaccagagcccga	11	5	10	15	1	1	1	1	0	0	1	2	3	2	2	4	1	5	4	4	1	0	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:7543261A>G	uc002mgk.1	-	4	439	c.430T>C	c.(430-432)TCC>CCC	p.S144P	PEX11G_uc002mgl.1_Missense_Mutation_p.S74P	NM_080662	NP_542393	Q96HA9	PX11C_HUMAN	peroxisomal biogenesis factor 11 gamma	144	Helical; (Potential).					integral to membrane|peroxisomal membrane					0						ATCCACAGGGACCTGCAGCAC	0.672													8	6					0	0	0	0	G	7543261	G	G	7543261	3	3	301	1	0	0	0	0	1	0	0	0	11794	289	10	5	303	5	PEX11G	19	7543261	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08	5445975	7543261	51585722	94	55428											
NOTCH3	4854	broad.mit.edu	37	chr19	15302902	15302902	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgtagccagctggacactggCagcggaaggagccaggtgtg	9	6	17	9	1	0	0	0	0	0	0	0	3	0	3	2	5	4	3	2	5	2	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:15302902C>G	uc002nan.2	-	4	624	c.548G>C	c.(547-549)TGC>TCC	p.C183S	NOTCH3_uc002nao.1_Missense_Mutation_p.C183S	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	183	Extracellular (Potential).|EGF-like 4; calcium-binding (Potential).		C -> R (in CADASIL).|C -> S (in CADASIL).|C -> F (in CADASIL).		Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TGGACACTGGCAGCGGAAGGA	0.672													12	32					0	0	0	0	G	15302902	G	G	15302902	3	3	301	1	0	0	0	0	1	0	0	0	10604	710	25	4	6537	4	NOTCH3	19	15302902	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	7759641	15302902	43826081	95	55429											
TMEM59L	25789	broad.mit.edu	37	chr19	18731326	18731326	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	taccaccctacaagctgaagCtggacctgaccaagctgtag	12	7	9	13	0	0	2	0	2	0	0	0	3	0	3	4	1	5	4	4	1	6	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:18731326C>T	uc002njy.3	+	8	1096	c.1009C>T	c.(1009-1011)CTG>TTG	p.L337L		NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	337						Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						CAAGCTGAAGCTGGACCTGAC	0.657													22	39					0	0	0	0	T	18731326	T	T	18731326	2	4	301	1	0	0	0	0	0	0	0	1	16252	796	28	4		4	TMEM59L	19	18731326	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08	3428424	18731326	40397657	96	55430											
ZNF302	55900	broad.mit.edu	37	chr19	35175210	35175210	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacaaagaaggatatttatGatgaagattcaccccaacca	18	8	6	9	0	1	4	1	2	0	2	1	5	1	5	3	1	2	0	3	1	7	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:35175210G>A	uc002nvr.1	+	6	663	c.400G>A	c.(400-402)GAT>AAT	p.D134N	ZNF302_uc002nvp.1_Missense_Mutation_p.D90N|ZNF302_uc002nvq.1_Missense_Mutation_p.D90N|ZNF302_uc002nvs.1_Missense_Mutation_p.D90N	NM_018443	NP_060913	Q9NR11	ZN302_HUMAN	zinc finger protein 302	Error:Variant_position_missing_in_Q9NR11_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GGATATTTATGATGAAGATTC	0.294													20	32					0	0	0	0	A	35175210	A	A	35175210	3	1	301	1	0	0	0	0	1	0	0	0	17899	1290	45	2	282	2	ZNF302	19	35175210	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	16443884	35175210	23953773	97	55431											
CAPNS1	826	broad.mit.edu	37	chr19	36633613	36633613	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	agtgaggaggtccggcagttCcggagactctttgcccagct	7	9	14	11	2	1	2	0	1	1	1	3	4	3	3	3	4	2	3	3	4	0	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:36633613C>A	uc002odj.2	+	4	460	c.303C>A	c.(301-303)TTC>TTA	p.F101L	CAPNS1_uc002odi.1_Missense_Mutation_p.F101L|CAPNS1_uc002odk.2_Missense_Mutation_p.F101L|CAPNS1_uc002odl.2_Missense_Mutation_p.F101L	NM_001749	NP_001740	P04632	CPNS1_HUMAN	calpain, small subunit 1	101	EF-hand 1; atypical.				positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TCCGGCAGTTCCGGAGACTCT	0.612													45	94					2.77807e-22	3.03451e-22	1	0	A	36633613	A	A	36633613	3	1	301	1	0	0	0	0	1	0	0	0	2645	854	30	2	313	2	CAPNS1	19	36633613	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	1458403	36633613	22495370	98	55432											
RAB4B	53916	broad.mit.edu	37	chr19	41289968	41289968	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcctggaggcctcccgctttGcccaggagaatggtgagggc	6	8	15	12	1	0	2	0	1	0	1	2	4	2	3	4	5	1	1	4	5	1	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:41289968G>T	uc002opd.1	+	5	528	c.418G>T	c.(418-420)GCC>TCC	p.A140S	RAB4B_uc002opc.1_RNA|RAB4B_uc002ope.1_Intron|EGLN2_uc010ehd.2_5'UTR|RAB4B_uc002opf.1_Missense_Mutation_p.A166S	NM_016154	NP_057238	P61018	RAB4B_HUMAN	ras-related GTP-binding protein 4b	140					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	intracellular|plasma membrane	GTP binding|GTPase activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CTCCCGCTTTGCCCAGGAGAA	0.627													18	29					8.34094e-07	8.5827e-07	1	0	T	41289968	T	T	41289968	3	4	301	1	0	0	0	0	1	0	0	0	13012	1319	46	4	436	4	RAB4B	19	41289968	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	4656355	41289968	17839015	99	55433											
FBXO46	23403	broad.mit.edu	37	chr19	46215924	46215924	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	ccccgcccccactgggcaggCcgctgtctggtgcacggggc	3	5	15	18	3	1	0	0	0	1	0	1	0	1	0	5	5	1	3	5	5	0	0			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:46215924C>T	uc002pcy.2	-	2	955	c.830G>A	c.(829-831)GGC>GAC	p.G277D	FBXO46_uc002pcz.2_Missense_Mutation_p.G277D	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	277							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		ACTGGGCAGGCCGCTGTCTGG	0.697													13	14					0	0	0	0	T	46215924	T	T	46215924	3	4	301	1	0	0	0	0	1	0	0	0	5787	739	26	4	985	4	FBXO46	19	46215924	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	4925956	46215924	12913059	100	55434											
GPR77	27202	broad.mit.edu	37	chr19	47844487	47844487	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgggcctgcctggtggtctaCggttcagcgggcgtgcgggg	2	8	20	11	5	2	0	1	0	1	0	2	0	2	0	2	7	4	1	2	7	1	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:47844487C>T	uc010ela.1	+	2	649	c.431C>T	c.(430-432)ACG>ATG	p.T144M	GPR77_uc002pgk.1_Missense_Mutation_p.T144M	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	144	Cytoplasmic (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		TGGTGGTCTACGGTTCAGCGG	0.677													34	71					0	0	0	0	T	47844487	T	T	47844487	3	4	301	1	0	0	0	0	1	0	0	0	6747	536	19	1	433	1	GPR77	19	47844487	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	1628563	47844487	11284496	101	55435											
ZNF665	79788	broad.mit.edu	37	chr19	53668506	53668506	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttgctaagtgtgaatactGagtgaaaaccttgacgcatt	13	13	9	6	1	0	4	0	4	0	0	0	4	0	4	1	0	3	2	1	0	5	5			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:53668506G>C	uc010eqm.1	-	4	1337	c.1237C>G	c.(1237-1239)CAG>GAG	p.Q413E		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	348	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TGTGAATACTGAGTGAAAACC	0.408													17	30					0	0	0	0	C	53668506	C	C	53668506	3	2	301	1	0	0	0	0	1	0	0	0	18140	1299	45	2	803	2	ZNF665	19	53668506	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	5824019	53668506	5460477	102	55436											
ZNF761	388561	broad.mit.edu	37	chr19	53959873	53959873	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	aactttagtcagaagtcatcCcttatatgccaccatagact	13	12	5	11	0	2	2	2	0	0	2	3	2	3	2	3	0	2	0	3	0	6	5			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr19:53959873C>T	uc010eqp.2	+	7	2570	c.2112C>T	c.(2110-2112)TCC>TCT	p.S704S	ZNF761_uc010ydy.1_Silent_p.S650S|ZNF761_uc002qbt.1_Silent_p.S650S	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	704	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		AGAAGTCATCCCTTATATGCC	0.388													27	65					0	0	0	0	T	53959873	T	T	53959873	2	4	301	1	0	0	0	0	0	0	0	1	18203	610	22	4		4	ZNF761	19	53959873	Silent	SNP	C	TCGA-HD-7832-01A-11D-2129-08	291367	53959873	5169110	103	55437											
ATRN	8455	broad.mit.edu	37	chr20	3565467	3565467	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atttctatccacagcccctgCtcaattccagcatgtgtcta	9	13	5	14	0	3	0	1	0	2	0	5	0	5	0	4	0	3	2	4	0	3	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr20:3565467C>T	uc002wim.2	+	18	3214	c.3124C>T	c.(3124-3126)CTC>TTC	p.L1042F	ATRN_uc002wil.2_Missense_Mutation_p.L1042F	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1042	Extracellular (Potential).|PSI 4.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						ACAGCCCCTGCTCAATTCCAG	0.458													59	101					0	0	0	0	T	3565467	T	T	3565467	3	4	301	1	0	0	0	0	1	0	0	0	1208	797	28	4	3194	4	ATRN	20	3565467	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08		3565467	59460053	104	55438											
ESF1	51575	broad.mit.edu	37	chr20	13763275	13763275	+	Frame_Shift_Del	DEL	T	-	-																															ctgtagtatgttgaacaatgTtttttttctctttcttattt																										TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr20:13763275delT	uc002woj.2	-	2	620	c.512delA	c.(511-513)AACfs	p.N171fs	ESF1_uc002wok.1_Frame_Shift_Del_p.N171fs|C20orf7_uc002wol.1_5'Flank|C20orf7_uc002wom.2_5'Flank|C20orf7_uc002won.2_5'Flank|C20orf7_uc002woo.2_5'Flank	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						TTGAACAATGTTTTTTTTCTC	0.318													---	---	---								-	13763275	-	-	13763275	7	5	301	1	0	1	0	1	0	0	0	0	5275	1725	60	0	2095	0	ESF1	20	13763275	Frame_Shift_Del	DEL	T	TCGA-HD-7832-01A-11D-2129-08	10197808	13763275	49262245	105	55439											
SEL1L2	80343	broad.mit.edu	37	chr20	13830958	13830958	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgtacaatcttctggccaagTgaatgtcctagaaggagaag	13	9	11	8	1	2	3	0	1	2	2	3	4	3	3	2	2	1	1	2	2	7	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr20:13830958T>G	uc010gcf.2	-	19	1908	c.1826A>C	c.(1825-1827)CAC>CCC	p.H609P	SEL1L2_uc002woq.3_Missense_Mutation_p.H470P|SEL1L2_uc010zrl.1_Missense_Mutation_p.H496P|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	609	Extracellular (Potential).|Sel1-like 11.					integral to membrane	binding			ovary(2)	2						TCTGGCCAAGTGAATGTCCTA	0.413													17	49					0	0	0	0	G	13830958	G	G	13830958	3	3	301	1	0	0	0	0	1	0	0	0	14076	1696	59	5	248	5	SEL1L2	20	13830958	Missense_Mutation	SNP	T	TCGA-HD-7832-01A-11D-2129-08	67683	13830958	49194562	106	55440											
SSTR4	6754	broad.mit.edu	37	chr20	23017025	23017025	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtcccttatccttagctatgCcaacagctgcgccaacccca	9	9	6	17	1	0	0	0	0	0	0	2	0	2	0	6	0	6	2	6	0	5	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr20:23017025C>T	uc002wsr.2	+	1	969	c.905C>T	c.(904-906)GCC>GTC	p.A302V		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	302	Helical; Name=7; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CTTAGCTATGCCAACAGCTGC	0.577													33	111					0	0	0	0	T	23017025	T	T	23017025	3	4	301	1	0	0	0	0	1	0	0	0	15266	739	26	4	907	4	SSTR4	20	23017025	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	9186067	23017025	40008495	107	55441											
ASXL1	171023	broad.mit.edu	37	chr20	31021439	31021439	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacccgacctggagggtcccGaattcccagttgagtctgtg	7	9	12	13	2	1	1	0	1	1	0	3	4	3	2	4	2	0	1	4	2	1	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr20:31021439G>A	uc002wxs.2	+	11	1864	c.1438G>A	c.(1438-1440)GAA>AAA	p.E480K	ASXL1_uc010geb.2_Missense_Mutation_p.E371K	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	480					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GGAGGGTCCCGAATTCCCAGT	0.597			F|N|Mis		MDS|CMML								15	161					0	0	0	0	A	31021439	A	A	31021439	3	1	301	1	0	0	0	0	1	0	0	0	1068	1059	37	1	1490	1	ASXL1	20	31021439	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	8004414	31021439	32004081	108	55442											
SYCP2	10388	broad.mit.edu	37	chr20	58443591	58443591	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acttagattatcttctatatAtattcttttgcgactaagat	12	19	4	6	1	3	2	0	0	3	2	3	3	3	2	0	0	1	0	0	0	7	11			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr20:58443591A>T	uc002yaz.2	-	37	4004	c.3865T>A	c.(3865-3867)TAT>AAT	p.Y1289N		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1289					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TCTTCTATATATATTCTTTTG	0.333													26	33					0	0	0	0	T	58443591	T	T	58443591	3	4	301	1	0	0	0	0	1	0	0	0	15498	449	16	5	759	5	SYCP2	20	58443591	Missense_Mutation	SNP	A	TCGA-HD-7832-01A-11D-2129-08	27422152	58443591	4581929	109	55443											
TCEA2	6919	broad.mit.edu	37	chr20	62701952	62701952	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cagacagacctgttcacctgCggcaagtgcaggaaaaagaa	15	5	11	10	1	1	3	1	0	0	3	1	4	1	4	2	2	2	3	2	2	4	1	rs141114667		TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr20:62701952C>A	uc011abs.1	+	8	1439	c.783C>A	c.(781-783)TGC>TGA	p.C261*	TCEA2_uc011abr.1_Nonsense_Mutation_p.C234*|TCEA2_uc010gks.2_Nonsense_Mutation_p.C262*	NM_003195	NP_003186	Q15560	TCEA2_HUMAN	transcription elongation factor A protein 2	261	TFIIS-type.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	transcription elongation factor complex	DNA binding|protein binding|translation elongation factor activity|zinc ion binding				0	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					TGTTCACCTGCGGCAAGTGCA	0.632													10	11					0.000442599	0.000452152	1	0	A	62701952	A	A	62701952	4	1	301	1	0	0	0	0	0	1	0	0	15734	776	27	3	813	3	TCEA2	20	62701952	Nonsense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	4258361	62701952	323568	110	55444											
ZNF70	7621	broad.mit.edu	37	chr22	24086332	24086332	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggcatttgtagggcttctcGccagtgtgggtcttgcggtg	3	14	16	8	2	2	0	0	0	2	0	3	0	2	0	1	4	1	3	1	4	1	4	rs141862105		TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr22:24086332G>A	uc002zxs.2	-	2	1457	c.996C>T	c.(994-996)GGC>GGT	p.G332G	ZNF70_uc002zxr.1_5'Flank	NM_021916	NP_068735	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	332						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						AGGGCTTCTCGCCAGTGTGGG	0.567													19	41					0	0	0	0	A	24086332	A	A	24086332	2	1	301	1	0	0	0	0	0	0	0	1	18170	1074	38	1		1	ZNF70	22	24086332	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08		24086332	27218234	111	55445											
LARGE	9215	broad.mit.edu	37	chr22	33670599	33670599	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taggcgttgggcagcacaatGaactcatactcctggaagaa	13	8	11	9	1	1	2	1	1	0	1	2	3	2	3	1	3	3	3	1	3	6	3			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr22:33670599G>A	uc003and.3	-	16	2664	c.2085C>T	c.(2083-2085)TTC>TTT	p.F695F	LARGE_uc011amd.1_Silent_p.F494F|LARGE_uc003ane.3_Silent_p.F695F|LARGE_uc010gwp.2_Silent_p.F643F|LARGE_uc011ame.1_Silent_p.F627F|LARGE_uc011amf.1_Silent_p.F646F	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	695	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				GCAGCACAATGAACTCATACT	0.507											OREG0026497	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	26					0	0	0	0	A	33670599	A	A	33670599	2	1	301	1	0	0	0	0	0	0	0	1	8667	1281	45	2		2	LARGE	22	33670599	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08	9584267	33670599	17633967	112	55446											
CBX6	23466	broad.mit.edu	37	chr22	39262468	39262468	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	agcagctgtgacctcaggcgGtgcccgcttgctggtggctg	4	9	16	12	2	1	1	1	1	0	0	1	1	1	1	2	4	4	5	2	4	0	1			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr22:39262468G>T	uc003awl.2	-	5	1048	c.985C>A	c.(985-987)CCG>ACG	p.P329T		NM_014292	NP_055107	O95503	CBX6_HUMAN	chromobox homolog 6	329					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex					0	Melanoma(58;0.04)					ACCTCAGGCGGTGCCCGCTTG	0.756													7	9					2.7689e-08	2.86995e-08	1	0	T	39262468	T	T	39262468	3	4	301	1	0	0	0	0	1	0	0	0	2734	1261	44	4	257	4	CBX6	22	39262468	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	5591869	39262468	12042098	113	55447											
CACNA1I	8911	broad.mit.edu	37	chr22	40061518	40061518	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcagtgtcatcagccgggcGccgggcctgaagctggtggt	5	8	17	11	3	3	1	3	1	0	0	3	1	3	1	3	4	2	1	3	4	1	0			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr22:40061518G>A	uc003ayc.2	+	22	3867	c.3867G>A	c.(3865-3867)GCG>GCA	p.A1289A	CACNA1I_uc003ayd.2_Silent_p.A1254A|CACNA1I_uc003aye.2_Silent_p.A1204A|CACNA1I_uc003ayf.2_Silent_p.A1169A	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1289	III.|Helical; Name=S4 of repeat III; (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TCAGCCGGGCGCCGGGCCTGA	0.617													22	32					0	0	0	0	A	40061518	A	A	40061518	2	1	301	1	0	0	0	0	0	0	0	1	2558	1074	38	1		1	CACNA1I	22	40061518	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08	799050	40061518	11243048	114	55448											
FBLN1	2192	broad.mit.edu	37	chr22	45937151	45937151	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	cagtgccccgtgccctatcgGgcatacatgcatcaacacag	10	7	9	15	2	1	0	1	0	0	0	2	0	1	0	3	1	5	2	3	1	3	2			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chr22:45937151G>A	uc003bgj.1	+	9	1112	c.965G>A	c.(964-966)GGG>GAG	p.G322E	FBLN1_uc003bgg.1_Missense_Mutation_p.G322E|FBLN1_uc003bgh.2_Missense_Mutation_p.G322E|FBLN1_uc010gzz.2_Missense_Mutation_p.G360E|FBLN1_uc003bgi.1_Missense_Mutation_p.G322E	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	322	EGF-like 4; calcium-binding (Potential).				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TGCCCTATCGGGCATACATGC	0.542													22	50					0	0	0	0	A	45937151	A	A	45937151	3	1	301	1	0	0	0	0	1	0	0	0	5730	1232	43	4	999	4	FBLN1	22	45937151	Missense_Mutation	SNP	G	TCGA-HD-7832-01A-11D-2129-08	5875633	45937151	5367415	115	55449											
MAGEB4	4115	broad.mit.edu	37	chrX	30260591	30260591	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gattctctaaccaggaagacGaagatgttagtgcagttcct	12	11	10	8	1	1	2	0	0	1	2	3	5	2	3	2	1	2	3	2	1	4	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chrX:30260591G>A	uc004dcb.2	+	1	423	c.339G>A	c.(337-339)ACG>ACA	p.T113T	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	113	MAGE.									ovary(1)	1						CCAGGAAGACGAAGATGTTAG	0.443													6	2					0	0	0	0	A	30260591	A	A	30260591	2	1	301	1	0	0	0	0	0	0	0	1	9231	1045	37	1		1	MAGEB4	23	30260591	Silent	SNP	G	TCGA-HD-7832-01A-11D-2129-08		30260591	125009969	116	55450											
HUWE1	10075	broad.mit.edu	37	chrX	53571556	53571556	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcttggctttcttgttagccCggcgcgtgtcgtcccggagc	2	12	14	13	5	1	0	0	0	1	0	3	1	2	1	2	3	2	3	2	3	1	4			TCGA-HD-7832-01A-11D-2129-08	TCGA-HD-7832-10A-01D-2129-08									Somatic	Phase_I	Capture				Illumina GAIIx	374f3e37-87e5-4450-a89f-0bde3981a31e	d6b68a0c-89b9-4474-8579-8c65728b9b06	g.chrX:53571556C>T	uc004dsp.2	-	72	11618	c.11216G>A	c.(11215-11217)CGG>CAG	p.R3739Q	HUWE1_uc004dsn.2_Missense_Mutation_p.R2547Q|HUWE1_uc004dsq.1_Missense_Mutation_p.R54Q	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3739					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CTTGTTAGCCCGGCGCGTGTC	0.537													16	5					0	0	0	0	T	53571556	T	T	53571556	3	4	301	1	0	0	0	0	1	0	0	0	7500	652	23	1	1960	1	HUWE1	23	53571556	Missense_Mutation	SNP	C	TCGA-HD-7832-01A-11D-2129-08	23310965	53571556	101699004	117	55451											
CAMTA1	23261	broad.mit.edu	37	chr1	7723421	7723421	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgatctccgcaggagctggcGgcagcgtgcatcacaagtgt	8	7	14	12	4	2	0	1	0	1	0	3	2	2	1	1	3	3	4	1	3	1	0			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr1:7723421G>A	uc001aoi.2	+	9	1021	c.814G>A	c.(814-816)GGC>AGC	p.G272S		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AGGAGCTGGCGGCAGCGTGCA	0.448													42	207					0	0	0	0	A	7723421	A	A	7723421	3	1	302	1	0	0	0	0	1	0	0	0	2625	1116	39	1	848	1	CAMTA1	1	7723421	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08		7723421	241527200	1	55452											
CSMD2	114784	broad.mit.edu	37	chr1	34192216	34192216	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	caggcacagctcaaggcatcCttgtagaagccaggccagcc	11	5	11	14	0	1	1	1	0	0	1	2	1	2	1	4	3	3	4	4	3	3	2			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr1:34192216C>T	uc001bxn.1	-	16	2348	c.2319G>A	c.(2317-2319)AAG>AAA	p.K773K	CSMD2_uc001bxm.1_Silent_p.K813K	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	773	CUB 5.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TCAAGGCATCCTTGTAGAAGC	0.617													9	44					0	0	0	0	T	34192216	T	T	34192216	2	4	302	1	0	0	0	0	0	0	0	1	3962	680	24	4		4	CSMD2	1	34192216	Silent	SNP	C	TCGA-HD-7917-01A-11D-2229-08	26468795	34192216	215058405	2	55453											
THRAP3	9967	broad.mit.edu	37	chr1	36769445	36769445	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaagtgggtgagccggggcCggggccgaggagcctttcct	6	6	18	11	3	0	1	0	1	0	0	1	3	1	2	5	6	2	0	5	6	1	1			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr1:36769445C>G	uc001cae.3	+	12	2919	c.2695C>G	c.(2695-2697)CGG>GGG	p.R899G	THRAP3_uc001caf.3_Missense_Mutation_p.R899G|C1orf113_uc010oia.1_5'Flank	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	899					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAGCCGGGGCCGGGGCCGAGG	0.597			T	USP6	aneurysmal bone cysts								27	104					0	0	0	0	G	36769445	G	G	36769445	3	3	302	1	0	0	0	0	1	0	0	0	15940	643	23	3	2733	3	THRAP3	1	36769445	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	2577229	36769445	212481176	3	55454											
KPRP	448834	broad.mit.edu	37	chr1	152733723	152733724	+	Frame_Shift_Ins	INS	-	C	C																															ctggtgatgtgtttccagagINScggaggggtcaggatggcca																										TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr1:152733723_152733724insC	uc001fal.1	+	2	1717_1718	c.1659_1660insC	c.(1657-1662)GAGCGGfs	p.E553fs		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	553_554						cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTTTCCAGAGCGGAGGGGTCA	0.54													---	---	---								C	152733724	C	C	152733723	7	5	302	1	0	1	1	0	0	0	0	0	8475	962	34	0	1661	0	KPRP	1	152733723	Frame_Shift_Ins	INS	-	TCGA-HD-7917-01A-11D-2229-08	115964278	152733723	96516898	4	55455											
PYHIN1	149628	broad.mit.edu	37	chr1	158906926	158906926	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	tcaaagaaataccaacactgGgagaccttgctgaaactctt	15	9	7	10	0	2	3	1	1	1	2	2	4	2	3	2	1	4	1	2	1	5	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr1:158906926G>A	uc001ftb.2	+	2	471	c.226G>A	c.(226-228)GGA>AGA	p.G76R	PYHIN1_uc001fta.3_Missense_Mutation_p.G76R|PYHIN1_uc001ftc.2_Missense_Mutation_p.G76R|PYHIN1_uc001ftd.2_Missense_Mutation_p.G76R|PYHIN1_uc001fte.2_Missense_Mutation_p.G76R	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	76	DAPIN.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					ACCAACACTGGGAGACCTTGC	0.428													8	32					0	0	0	0	A	158906926	A	A	158906926	3	1	302	1	0	0	0	0	1	0	0	0	12930	1233	43	4	228	4	PYHIN1	1	158906926	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	6173203	158906926	90343695	5	55456											
OR2M2	391194	broad.mit.edu	37	chr1	248344093	248344093	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cacatctgatcactccccaaCgcaggacaagatggtgtctg	11	8	9	13	1	3	2	1	1	2	1	4	3	4	3	2	2	1	1	2	2	2	0	rs149761766		TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr1:248344093C>T	uc010pzf.1	+	1	806	c.806C>T	c.(805-807)ACG>ATG	p.T269M		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CACTCCCCAACGCAGGACAAG	0.502													38	136					0	0	0	0	T	248344093	T	T	248344093	3	4	302	1	0	0	0	0	1	0	0	0	11064	536	19	1	808	1	OR2M2	1	248344093	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	89437167	248344093	906528	6	55457											
NRXN1	9378	broad.mit.edu	37	chr2	51255025	51255025	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggcctccacctggtcgatGaagagcgtggtgttgcggaa	7	10	15	9	3	0	2	0	1	0	1	2	4	1	3	3	4	2	1	3	4	2	2			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr2:51255025G>A	uc010fbq.2	-	2	1864	c.387C>T	c.(385-387)TTC>TTT	p.F129F	NRXN1_uc002rxe.3_Silent_p.F129F|NRXN1_uc002rxd.1_Silent_p.F129F	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCTGGTCGATGAAGAGCGTGG	0.672													7	30					0	0	0	0	A	51255025	A	A	51255025	2	1	302	1	0	0	0	0	0	0	0	1	10719	1281	45	2		2	NRXN1	2	51255025	Silent	SNP	G	TCGA-HD-7917-01A-11D-2229-08		51255025	191944348	7	55458											
MAT2A	4144	broad.mit.edu	37	chr2	85770060	85770060	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gagtttctcatccattatctAtctccattttccattatggt	8	19	4	10	0	3	0	1	0	3	0	7	1	5	0	3	1	0	1	3	1	3	6			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr2:85770060A>G	uc002spr.2	+	8	1111	c.988A>G	c.(988-990)ATC>GTC	p.I330V	MAT2A_uc010ysr.1_Missense_Mutation_p.I330V|MAT2A_uc010fgk.2_Missense_Mutation_p.I304V|MAT2A_uc010fgl.2_Missense_Mutation_p.I267V	NM_005911	NP_005902	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	330					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TCCATTATCTATCTCCATTTT	0.388													16	42					0	0	0	0	G	85770060	G	G	85770060	3	3	302	1	0	0	0	0	1	0	0	0	9383	449	16	5	1018	5	MAT2A	2	85770060	Missense_Mutation	SNP	A	TCGA-HD-7917-01A-11D-2229-08	34515035	85770060	157429313	8	55459											
VWA3B	200403	broad.mit.edu	37	chr2	98744737	98744737	+	Silent	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactttgtggtgggggatgtTcctgaagaatccaaggagct	9	12	14	6	0	0	2	0	1	0	1	2	4	2	4	2	4	2	2	2	4	4	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr2:98744737T>A	uc002syo.2	+	6	1002	c.738T>A	c.(736-738)GTT>GTA	p.V246V	VWA3B_uc010yvh.1_Silent_p.V96V|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Intron|VWA3B_uc002sym.2_Silent_p.V246V|VWA3B_uc002syn.1_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	246										ovary(3)|large_intestine(2)|skin(1)	6						TGGGGGATGTTCCTGAAGAAT	0.498													39	91					0	0	0	0	A	98744737	A	A	98744737	2	1	302	1	0	0	0	0	0	0	0	1	17309	1770	62	5		5	VWA3B	2	98744737	Silent	SNP	T	TCGA-HD-7917-01A-11D-2229-08	12974677	98744737	144454636	9	55460											
CLASP1	23332	broad.mit.edu	37	chr2	122227521	122227521	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	taccatccacagaatcttcaTcgtcgaaatttttatctgaa	13	14	4	10	2	3	2	1	1	2	1	6	3	4	2	2	0	1	0	2	0	5	5			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr2:122227521T>C	uc002tnc.2	-	9	1118	c.728A>G	c.(727-729)GAT>GGT	p.D243G	CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.D243G|CLASP1_uc010yza.1_Missense_Mutation_p.D243G|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tng.1_Missense_Mutation_p.D243G	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	243					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					AGAATCTTCATCGTCGAAATT	0.368													20	37					0	0	0	0	C	122227521	C	C	122227521	3	2	302	1	0	0	0	0	1	0	0	0	3469	1435	50	5	4068	5	CLASP1	2	122227521	Missense_Mutation	SNP	T	TCGA-HD-7917-01A-11D-2229-08	23482784	122227521	120971852	10	55461											
HOXD3	3232	broad.mit.edu	37	chr2	177036315	177036315	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcacggcatacacgagcgcGcagctggtggaattggaaaa	12	5	14	10	5	0	0	0	0	0	0	0	3	0	2	0	4	3	4	0	4	4	2			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr2:177036315G>A	uc002ukt.1	+	3	788	c.612G>A	c.(610-612)GCG>GCA	p.A204A		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	204	Homeobox.				anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		ACACGAGCGCGCAGCTGGTGG	0.637													15	39					0	0	0	0	A	177036315	A	A	177036315	2	1	302	1	0	0	0	0	0	0	0	1	7362	1074	38	1		1	HOXD3	2	177036315	Silent	SNP	G	TCGA-HD-7917-01A-11D-2229-08	54808794	177036315	66163058	11	55462											
WDR6	11180	broad.mit.edu	37	chr3	49052506	49052506	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atgctgcccatgtgacaggcCtcaagatcctaagcccaagc	11	7	9	14	0	1	2	1	1	0	1	2	2	2	2	4	1	4	1	4	1	3	1			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr3:49052506C>T	uc003cvj.2	+	6	3379	c.3241C>T	c.(3241-3243)CTC>TTC	p.L1081F	WDR6_uc011bby.1_Missense_Mutation_p.L529F|WDR6_uc010hkn.2_Missense_Mutation_p.L1025F|WDR6_uc011bbz.1_Missense_Mutation_p.L1000F|DALRD3_uc003cvk.1_3'UTR|DALRD3_uc003cvl.1_3'UTR|DALRD3_uc003cvm.1_3'UTR|DALRD3_uc010hko.1_3'UTR	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	1051	WD 16.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		TGTGACAGGCCTCAAGATCCT	0.567													11	26					0	0	0	0	T	49052506	T	T	49052506	3	4	302	1	0	0	0	0	1	0	0	0	17378	681	24	4	3263	4	WDR6	3	49052506	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08		49052506	148969924	12	55463											
SLCO2A1	6578	broad.mit.edu	37	chr3	133667421	133667421	+	Frame_Shift_Del	DEL	T	-	-																															ctgctgaggtgccatactgcTtctccaggaacttgttgagg																										TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr3:133667421delT	uc003eqa.3	-	8	1338	c.1064delA	c.(1063-1065)AAGfs	p.K355fs	SLCO2A1_uc003eqb.3_Frame_Shift_Del_p.K279fs|SLCO2A1_uc011blv.1_Frame_Shift_Del_p.K174fs	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	355	Extracellular (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						GCCATACTGCTTCTCCAGGAA	0.597													---	---	---								-	133667421	-	-	133667421	7	5	302	1	0	1	0	1	0	0	0	0	14790	1609	56	0	895	0	SLCO2A1	3	133667421	Frame_Shift_Del	DEL	T	TCGA-HD-7917-01A-11D-2229-08	84614915	133667421	64355009	13	55464											
ESYT3	83850	broad.mit.edu	37	chr3	138180986	138180986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccacctggtgctgcccaacCgtgtgactgtgcctgtgaag	6	9	12	14	1	0	2	0	2	0	0	0	2	0	2	5	1	4	1	5	1	2	0			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr3:138180986C>T	uc003esk.2	+	8	1079	c.853C>T	c.(853-855)CGT>TGT	p.R285C	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	285						integral to membrane|plasma membrane					0						GCTGCCCAACCGTGTGACTGT	0.607													21	67					0	0	0	0	T	138180986	T	T	138180986	3	4	302	1	0	0	0	0	1	0	0	0	5290	652	23	1	883	1	ESYT3	3	138180986	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	4513565	138180986	59841444	14	55465											
RASA2	5922	broad.mit.edu	37	chr3	141328287	141328287	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccctgcagacatccaaataGatattgatgaagacagagaa	17	8	8	8	0	0	6	0	2	0	4	2	7	2	6	2	0	1	1	2	0	5	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr3:141328287G>C	uc003etz.1	+	22	2251	c.2251G>C	c.(2251-2253)GAT>CAT	p.D751H	RASA2_uc010huq.1_Missense_Mutation_p.D755H|RASA2_uc003eua.1_Missense_Mutation_p.D752H	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	751					intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						CATCCAAATAGATATTGATGA	0.294													18	46					0	0	0	0	C	141328287	C	C	141328287	3	2	302	1	0	0	0	0	1	0	0	0	13126	942	33	2	2337	2	RASA2	3	141328287	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	3147301	141328287	56694143	15	55466											
UGDH	7358	broad.mit.edu	37	chr4	39511382	39511382	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agaaaaatttgaatttaccaAcactggcttttagaaacttg	16	13	6	6	0	0	3	0	1	0	2	0	3	0	3	1	1	3	1	1	1	7	6			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr4:39511382A>C	uc003guk.1	-	6	1125	c.809T>G	c.(808-810)GTT>GGT	p.V270G	UGDH_uc011byp.1_Missense_Mutation_p.V173G|UGDH_uc003gul.1_Missense_Mutation_p.V203G	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	270	Substrate binding.				glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	GAATTTACCAACACTGGCTTT	0.254													9	46					0	0	0	0	C	39511382	C	C	39511382	3	2	302	1	0	0	0	0	1	0	0	0	17008	43	2	5	703	5	UGDH	4	39511382	Missense_Mutation	SNP	A	TCGA-HD-7917-01A-11D-2229-08		39511382	151642894	16	55467											
CCT5	22948	broad.mit.edu	37	chr5	10254818	10254818	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgatggtggataaggatggaGatgtgactgtaactaatgat	13	12	14	2	0	0	4	0	3	0	1	0	7	0	6	0	4	1	1	0	4	3	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr5:10254818G>T	uc003jeq.2	+	3	370	c.199G>T	c.(199-201)GAT>TAT	p.D67Y	CCT5_uc011cmq.1_Intron|CCT5_uc003jer.2_Missense_Mutation_p.D67Y|CCT5_uc010its.2_Missense_Mutation_p.D67Y|CCT5_uc011cmr.1_Intron|CCT5_uc011cms.1_Missense_Mutation_p.D29Y|CCT5_uc011cmt.1_Intron	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	67					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						TAAGGATGGAGATGTGACTGT	0.413													47	54					1.59911e-31	1.79178e-31	1	0	T	10254818	T	T	10254818	3	4	302	1	0	0	0	0	1	0	0	0	2971	942	33	2	209	2	CCT5	5	10254818	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08		10254818	170660442	17	55468											
SPEF2	79925	broad.mit.edu	37	chr5	35704673	35704673	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tagctgaagaattgtcctatAaaactgctcacgaagatatc	15	11	7	8	1	1	3	1	1	0	2	3	4	2	3	1	0	3	2	1	0	8	5			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr5:35704673A>G	uc003jjo.2	+	17	2527	c.2416A>G	c.(2416-2418)AAA>GAA	p.K806E	SPEF2_uc003jjq.3_Missense_Mutation_p.K801E|SPEF2_uc003jjp.1_Missense_Mutation_p.K292E	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	806					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATTGTCCTATAAAACTGCTCA	0.323													26	26					0	0	0	0	G	35704673	G	G	35704673	3	3	302	1	0	0	0	0	1	0	0	0	15101	363	13	5	2503	5	SPEF2	5	35704673	Missense_Mutation	SNP	A	TCGA-HD-7917-01A-11D-2229-08	25449855	35704673	145210587	18	55469											
RICTOR	253260	broad.mit.edu	37	chr5	38967297	38967297	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tacgaataaatgcagagagtAtcagtgccaaataattatcc	17	10	7	7	1	1	1	1	0	0	1	2	3	2	1	2	0	3	2	2	0	8	5			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr5:38967297A>T	uc003jlp.2	-	14	1208	c.1184T>A	c.(1183-1185)ATA>AAA	p.I395K	RICTOR_uc003jlo.2_Missense_Mutation_p.I395K|RICTOR_uc010ivf.2_Missense_Mutation_p.I110K	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	395					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TGCAGAGAGTATCAGTGCCAA	0.299													126	136					0	0	0	0	T	38967297	T	T	38967297	3	4	302	1	0	0	0	0	1	0	0	0	13423	449	16	5	4042	5	RICTOR	5	38967297	Missense_Mutation	SNP	A	TCGA-HD-7917-01A-11D-2229-08	3262624	38967297	141947963	19	55470											
ETF1	2107	broad.mit.edu	37	chr5	137847182	137847182	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acctattaatttcttctcttGaatgaatttcacgttggaga	11	17	6	7	1	3	3	1	2	2	1	4	4	3	3	1	1	0	1	1	1	4	7			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr5:137847182G>T	uc003ldc.3	-	7	1009	c.844C>A	c.(844-846)CAA>AAA	p.Q282K	ETF1_uc011cyv.1_Missense_Mutation_p.Q268K|ETF1_uc010jex.2_RNA|ETF1_uc003ldd.3_Missense_Mutation_p.Q249K|ETF1_uc010jey.1_Missense_Mutation_p.Q88K	NM_004730	NP_004721	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	282					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTCTTCTCTTGAATGAATTTC	0.254													23	20					7.33532e-06	7.8412e-06	1	0	T	137847182	T	T	137847182	3	4	302	1	0	0	0	0	1	0	0	0	5292	1299	45	2	489	2	ETF1	5	137847182	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	98879885	137847182	43068078	20	55471											
SPINK5	11005	broad.mit.edu	37	chr5	147503463	147503463	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaccagagaaaataaccCtgttcgaggcccatatggca	13	7	9	12	1	0	1	0	0	0	1	1	3	0	1	3	2	2	3	3	2	4	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr5:147503463C>G	uc003lox.2	+	27	2679	c.2606C>G	c.(2605-2607)CCT>CGT	p.P869R	SPINK5_uc010jgr.2_Missense_Mutation_p.P850R|SPINK5_uc003low.2_Missense_Mutation_p.P869R|SPINK5_uc003loy.2_Missense_Mutation_p.P869R	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	869	Kazal-like 13.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAATAACCCTGTTCGAGGC	0.398													14	20					0	0	0	0	G	147503463	G	G	147503463	3	3	302	1	0	0	0	0	1	0	0	0	15128	681	24	4	2712	4	SPINK5	5	147503463	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	9656281	147503463	33411797	21	55472											
FAT2	2196	broad.mit.edu	37	chr5	150928976	150928976	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttgcctcataatggagctGagtgaagcggggtgggtgga	9	9	17	6	1	1	2	1	2	0	0	1	4	1	4	1	5	3	1	1	5	2	2			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr5:150928976G>A	uc003lue.3	-	8	4682	c.4669C>T	c.(4669-4671)CAG>TAG	p.Q1557*	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1557	Extracellular (Potential).|Cadherin 14.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TAATGGAGCTGAGTGAAGCGG	0.572													20	24					0	0	0	0	A	150928976	A	A	150928976	4	1	302	1	0	0	0	0	0	1	0	0	5722	1299	45	2	8444	2	FAT2	5	150928976	Nonsense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	3425513	150928976	29986284	22	55473											
NSD1	64324	broad.mit.edu	37	chr5	176639004	176639004	+	Frame_Shift_Del	DEL	G	-	-																															ctgtgcaggaggggcgggatGagtttccagagcatagaact																										TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr5:176639004delG	uc003mfr.3	+	5	3742	c.3604delG	c.(3604-3606)GAGfs	p.E1202fs	NSD1_uc003mft.3_Frame_Shift_Del_p.E933fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.E1099fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.E850fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1202					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GGGGCGGGATGAGTTTCCAGA	0.468			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---								-	176639004	-	-	176639004	7	5	302	1	0	1	0	1	0	0	0	0	10723	1291	45	0	3618	0	NSD1	5	176639004	Frame_Shift_Del	DEL	G	TCGA-HD-7917-01A-11D-2229-08	25710028	176639004	4276256	23	55474											
BAI3	577	broad.mit.edu	37	chr6	69949024	69949024	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctctctggctaggtacatacGctctgagagatccataatac	11	11	8	11	1	2	2	0	1	2	1	4	3	3	2	1	2	3	3	1	2	5	5			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr6:69949024G>A	uc003pev.3	+	20	3168	c.2720G>A	c.(2719-2721)CGC>CAC	p.R907H	BAI3_uc010kak.2_Missense_Mutation_p.R907H|BAI3_uc011dxx.1_Missense_Mutation_p.R113H|BAI3_uc003pex.1_Missense_Mutation_p.R37H	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	907	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AGGTACATACGCTCTGAGAGA	0.368													33	101					0	0	0	0	A	69949024	A	A	69949024	3	1	302	1	0	0	0	0	1	0	0	0	1302	1087	38	1	2790	1	BAI3	6	69949024	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08		69949024	101166043	24	55475											
LCA5	167691	broad.mit.edu	37	chr6	80197508	80197508	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttggtaccttccagtttccCactctggcttttcttctctt	3	19	6	13	0	3	0	0	0	3	0	6	0	5	0	3	2	1	4	3	2	1	8			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr6:80197508C>T	uc003pix.2	-	8	1742	c.1307G>A	c.(1306-1308)TGG>TAG	p.W436*	LCA5_uc003piy.2_Nonsense_Mutation_p.W436*	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	436	Potential.				protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TCCAGTTTCCCACTCTGGCTT	0.348													16	39					0	0	0	0	T	80197508	T	T	80197508	4	4	302	1	0	0	0	0	0	1	0	0	8696	595	21	4	790	4	LCA5	6	80197508	Nonsense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	10248484	80197508	90917559	25	55476											
EPHA7	2045	broad.mit.edu	37	chr6	93965560	93965560	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcttacagtagttgtatagaCagcttctggatcatcctcta	10	15	7	9	0	4	1	1	0	3	1	5	2	5	2	1	1	2	4	1	1	5	7			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr6:93965560C>A	uc003poe.2	-	13	2609	c.2368G>T	c.(2368-2370)GTC>TTC	p.V790F	EPHA7_uc003pof.2_Missense_Mutation_p.V785F|EPHA7_uc011eac.1_Missense_Mutation_p.V786F	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	790	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GTTGTATAGACAGCTTCTGGA	0.383													14	42					2.32078e-09	2.50969e-09	1	0	A	93965560	A	A	93965560	3	1	302	1	0	0	0	0	1	0	0	0	5196	478	17	4	648	4	EPHA7	6	93965560	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	13768052	93965560	77149507	26	55477											
SIM1	6492	broad.mit.edu	37	chr6	100896374	100896374	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cctggagtccagaaagatgaGcttcatgtccaggctggcgc	9	8	13	11	1	1	3	1	1	0	2	3	4	3	4	3	3	1	2	3	3	1	1			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr6:100896374G>C	uc003pqj.3	-	6	931	c.724C>G	c.(724-726)CTC>GTC	p.L242V	SIM1_uc010kcu.2_Missense_Mutation_p.L242V	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	242	PAS 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AGAAAGATGAGCTTCATGTCC	0.607													7	21					0	0	0	0	C	100896374	C	C	100896374	3	2	302	1	0	0	0	0	1	0	0	0	14388	971	34	4	1600	4	SIM1	6	100896374	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	6930814	100896374	70218693	27	55478											
GIMAP2	26157	broad.mit.edu	37	chr7	150389615	150389615	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcattattgacacaccagatAtgttttcttggaaggaccac	12	13	7	9	0	2	2	1	1	1	1	2	4	2	4	2	2	0	1	2	2	3	6			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr7:150389615A>G	uc003who.2	+	3	329	c.241A>G	c.(241-243)ATG>GTG	p.M81V	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	81						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACACCAGATATGTTTTCTTG	0.368													10	22					0	0	0	0	G	150389615	G	G	150389615	3	3	302	1	0	0	0	0	1	0	0	0	6417	449	16	5	247	5	GIMAP2	7	150389615	Missense_Mutation	SNP	A	TCGA-HD-7917-01A-11D-2229-08		150389615	8749048	28	55479											
ATP6V1B2	526	broad.mit.edu	37	chr8	20074763	20074763	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atcaatgtgctgccctcactAtcacggttaatgaagtctgc	10	12	8	11	1	4	1	3	1	1	0	4	1	4	1	1	1	3	2	1	1	4	2	rs150784341	byFrequency	TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr8:20074763A>G	uc003wzp.2	+	12	1408	c.1194A>G	c.(1192-1194)CTA>CTG	p.L398L	ATP6V1B2_uc003wzq.1_5'Flank	NM_001693	NP_001684	P21281	VATB2_HUMAN	vacuolar H+ATPase B2	398					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		TGCCCTCACTATCACGGTTAA	0.373													26	121					0	0	0	0	G	20074763	G	G	20074763	2	3	302	1	0	0	0	0	0	0	0	1	1181	436	16	5		5	ATP6V1B2	8	20074763	Silent	SNP	A	TCGA-HD-7917-01A-11D-2229-08		20074763	126289259	29	55480											
VPS13B	157680	broad.mit.edu	37	chr8	100286454	100286454	+	Silent	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctaagaatcccctgccaacTcttgagggctcaatccagaa	12	9	7	13	0	3	3	1	1	2	2	5	3	5	3	4	1	2	1	4	1	5	2			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr8:100286454T>G	uc003yiv.2	+	18	2655	c.2544T>G	c.(2542-2544)ACT>ACG	p.T848T	VPS13B_uc003yiw.2_Silent_p.T848T|VPS13B_uc003yiu.1_Silent_p.T848T|VPS13B_uc003yix.1_Silent_p.T319T	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	848					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCCTGCCAACTCTTGAGGGCT	0.378													47	83					0	0	0	0	G	100286454	G	G	100286454	2	3	302	1	0	0	0	0	0	0	0	1	17258	1538	54	5		5	VPS13B	8	100286454	Silent	SNP	T	TCGA-HD-7917-01A-11D-2229-08	80211691	100286454	46077568	30	55481											
FAM83H	286077	broad.mit.edu	37	chr8	144809798	144809798	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccgggagccagcacgtcGtcttcgtaagcctccgcttc	5	8	10	18	5	1	0	0	0	1	0	5	1	2	1	5	1	3	3	5	1	1	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr8:144809798G>A	uc003yzk.2	-	5	1902	c.1833C>T	c.(1831-1833)GAC>GAT	p.D611D	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	611					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCAGCACGTCGTCTTCGTAAG	0.731													10	7					0	0	0	0	A	144809798	A	A	144809798	2	1	302	1	0	0	0	0	0	0	0	1	5672	1136	40	1		1	FAM83H	8	144809798	Silent	SNP	G	TCGA-HD-7917-01A-11D-2229-08	44523344	144809798	1554224	31	55482											
DNM1	1759	broad.mit.edu	37	chr9	130982587	130982587	+	Frame_Shift_Del	DEL	G	-	-																															cgccacttggctgaccgtatGggcacgccctacctgcagaa																										TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr9:130982587delG	uc011mau.1	+	6	903	c.816delG	c.(814-816)ATGfs	p.M272fs	DNM1_uc010mxr.2_Frame_Shift_Del_p.M272fs|DNM1_uc011mat.1_Frame_Shift_Del_p.M272fs	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	272					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						CTGACCGTATGGGCACGCCCT	0.522													---	---	---								-	130982587	-	-	130982587	7	5	302	1	0	1	0	1	0	0	0	0	4692	1348	47	0	838	0	DNM1	9	130982587	Frame_Shift_Del	DEL	G	TCGA-HD-7917-01A-11D-2229-08		130982587	10230844	32	55483											
CUBN	8029	broad.mit.edu	37	chr10	16943387	16943387	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cagcgaagagcagtgggtcaGgctgtcataagcatttggat	11	9	14	7	1	2	1	2	0	0	1	2	3	2	2	0	3	3	3	0	3	2	2			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr10:16943387G>T	uc001ioo.2	-	52	8186	c.8134C>A	c.(8134-8136)CTG>ATG	p.L2712M	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.L68M	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2712	CUB 20.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGTGGGTCAGGCTGTCATAA	0.478													24	72					3.6726e-16	4.0661e-16	1	0	T	16943387	T	T	16943387	3	4	302	1	0	0	0	0	1	0	0	0	4068	991	35	4	2801	4	CUBN	10	16943387	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08		16943387	118591360	33	55484											
ZEB1	6935	broad.mit.edu	37	chr10	31816010	31816012	+	In_Frame_Del	DEL	GAG	-	-																															aaccacaaggggatgaggaaGaggaggaggaggaggaagaa																										TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr10:31816010_31816012delGAG	uc001ivs.3	+	9	3256_3258	c.3193_3195delGAG	c.(3193-3195)GAGdel	p.E1071del	ZEB1_uc001ivr.3_In_Frame_Del_p.E853del|ZEB1_uc010qee.1_In_Frame_Del_p.E853del|ZEB1_uc010qef.1_In_Frame_Del_p.E853del|ZEB1_uc001ivt.3_In_Frame_Del_p.E853del|ZEB1_uc001ivu.3_In_Frame_Del_p.E1072del|ZEB1_uc001ivv.3_In_Frame_Del_p.E1051del|ZEB1_uc010qeh.1_In_Frame_Del_p.E1004del|ZEB1_uc009xlp.2_In_Frame_Del_p.E1055del	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	1071	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				ggatgaggaagaggaggaggagg	0.118													---	---	---								-	31816012	-	-	31816010	7	5	302	1	0	1	0	1	0	0	0	0	17690	943	33	0	3241	0	ZEB1	10	31816010	In_Frame_Del	DEL	GAG	TCGA-HD-7917-01A-11D-2229-08	14872623	31816010	103718737	34	55485											
C10orf28	27291	broad.mit.edu	37	chr10	99991344	99991344	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	acaatcatgaagttcctgatAttgacctcagtgattgtgaa	13	13	8	7	0	2	5	2	5	0	0	3	5	3	5	2	0	0	1	2	0	4	4			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr10:99991344A>G	uc001kow.3	+	5	2156	c.1861A>G	c.(1861-1863)ATT>GTT	p.I621V	C10orf28_uc001kox.3_Missense_Mutation_p.I635V|C10orf28_uc001koy.3_Missense_Mutation_p.I621V|C10orf28_uc009xvx.2_Missense_Mutation_p.I621V|C10orf28_uc009xvy.2_Missense_Mutation_p.I27V|C10orf28_uc001koz.3_RNA	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	621							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		AGTTCCTGATATTGACCTCAG	0.393													26	46					0	0	0	0	G	99991344	G	G	99991344	3	3	302	1	0	0	0	0	1	0	0	0	1607	449	16	5	1867	5	C10orf28	10	99991344	Missense_Mutation	SNP	A	TCGA-HD-7917-01A-11D-2229-08	68175334	99991344	35543403	35	55486											
COL17A1	1308	broad.mit.edu	37	chr10	105837245	105837246	+	Frame_Shift_Del	DEL	AG	-	-																															ccagccggctccctccaccaAgagaggctgttttagcatag																										TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr10:105837245_105837246delAG	uc001kxr.2	-	4	305_306	c.136_137delCT	c.(136-138)CTTfs	p.L46fs	COL17A1_uc010qqv.1_Frame_Shift_Del_p.L46fs|COL17A1_uc009xxp.1_Frame_Shift_Del_p.L46fs	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	46	Cytoplasmic (Potential).|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CCCTCCACCAAGAGAGGCTGTT	0.545													---	---	---								-	105837246	-	-	105837245	7	5	302	1	0	1	0	1	0	0	0	0	3689	72	3	0	4568	0	COL17A1	10	105837245	Frame_Shift_Del	DEL	AG	TCGA-HD-7917-01A-11D-2229-08	5845901	105837245	29697502	36	55487											
C10orf118	55088	broad.mit.edu	37	chr10	115891782	115891782	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	attgtgactgcaaagaattgGattcagactgaagctgtgca	13	11	11	6	0	1	4	1	2	0	2	1	5	1	5	0	1	3	3	0	1	3	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr10:115891782G>A	uc001lbb.1	-	11	2469	c.1817C>T	c.(1816-1818)TCC>TTC	p.S606F	C10orf118_uc009xyd.1_Missense_Mutation_p.S204F|C10orf118_uc001lbc.1_Missense_Mutation_p.S606F|C10orf118_uc009xye.1_RNA	NM_018017	NP_060487	Q7Z3E2	CJ118_HUMAN	CTCL tumor antigen L14-2	606	Potential.									ovary(2)	2		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		CAAAGAATTGGATTCAGACTG	0.378													31	63					0	0	0	0	A	115891782	A	A	115891782	3	1	302	1	0	0	0	0	1	0	0	0	1593	1174	41	2	903	2	C10orf118	10	115891782	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	10054537	115891782	19642965	37	55488											
EPS8L2	64787	broad.mit.edu	37	chr11	720606	720606	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgtacccgcaggaggagctgGaagacttcccgctgcccacg	8	6	13	14	3	0	1	0	0	0	1	1	4	1	4	3	3	3	4	3	3	2	2			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr11:720606G>C	uc001lqt.2	+	6	584	c.337G>C	c.(337-339)GAA>CAA	p.E113Q	EPS8L2_uc010qwj.1_Missense_Mutation_p.E129Q|EPS8L2_uc001lqu.2_Missense_Mutation_p.E113Q|EPS8L2_uc010qwk.1_Missense_Mutation_p.E129Q|EPS8L2_uc001lqv.2_Missense_Mutation_p.E68Q|EPS8L2_uc001lqw.2_5'Flank|EPS8L2_uc001lqx.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	113	PID.					cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGAGGAGCTGGAAGACTTCCC	0.677													4	17					0	0	0	0	C	720606	C	C	720606	3	2	302	1	0	0	0	0	1	0	0	0	5220	1175	41	2	355	2	EPS8L2	11	720606	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08		720606	134285910	38	55489											
FIBIN	387758	broad.mit.edu	37	chr11	27016455	27016455	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gggagtcccaccagatcgggGatgcctactccaactcggac	9	6	12	14	2	0	1	0	0	0	1	4	4	2	4	4	4	3	0	4	4	2	1			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr11:27016455G>C	uc001mrd.2	+	1	828	c.382G>C	c.(382-384)GAT>CAT	p.D128H		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	128						extracellular region|Golgi apparatus					0						CCAGATCGGGGATGCCTACTC	0.602													13	60					0	0	0	0	C	27016455	C	C	27016455	3	2	302	1	0	0	0	0	1	0	0	0	5917	1174	41	2	384	2	FIBIN	11	27016455	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	26295849	27016455	107990061	39	55490											
SUV420H1	51111	broad.mit.edu	37	chr11	67939048	67939048	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caggacccagccagagttgaGcacagtttttccttgtggag	9	10	12	10	0	0	2	0	1	0	1	1	4	1	4	3	2	2	3	3	2	0	4			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr11:67939048G>C	uc001onm.1	-	7	1038	c.782C>G	c.(781-783)GCT>GGT	p.A261G	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_Missense_Mutation_p.A89G|SUV420H1_uc009ysf.2_Missense_Mutation_p.A21G|SUV420H1_uc001ono.1_Missense_Mutation_p.A261G|SUV420H1_uc001onp.2_Missense_Mutation_p.A261G|SUV420H1_uc010rqa.1_Missense_Mutation_p.A238G|SUV420H1_uc001onq.2_Missense_Mutation_p.A261G	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	261	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CCAGAGTTGAGCACAGTTTTT	0.463													9	19					0	0	0	0	C	67939048	C	C	67939048	3	2	302	1	0	0	0	0	1	0	0	0	15480	971	34	4	1903	4	SUV420H1	11	67939048	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	40922593	67939048	67067468	40	55491											
PPFIA1	8500	broad.mit.edu	37	chr11	70222703	70222703	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggactgatagaaggtttgaTgaagtaagtttttggcctaa	12	13	13	3	0	0	4	0	3	0	1	0	5	0	5	1	3	0	3	1	3	5	6			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr11:70222703T>C	uc001opo.2	+	25	3579	c.3381T>C	c.(3379-3381)GAT>GAC	p.D1127D	PPFIA1_uc001opn.1_Silent_p.D1127D|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opr.2_Silent_p.D266D|PPFIA1_uc001ops.2_Silent_p.D166D|uc001opt.1_Intron	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	1127					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			GAAGGTTTGATGAAGTAAGTT	0.323													19	88					0	0	0	0	C	70222703	C	C	70222703	2	2	302	1	0	0	0	0	0	0	0	1	12364	1461	51	5		5	PPFIA1	11	70222703	Silent	SNP	T	TCGA-HD-7917-01A-11D-2229-08	2283655	70222703	64783813	41	55492											
FOLR4	390243	broad.mit.edu	37	chr11	94040769	94040769	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcaaccccaatgtggccGtggcccgcctcttcgccagc	6	6	12	17	3	1	0	0	0	1	0	2	0	1	0	6	3	2	1	6	3	2	1			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr11:94040769G>A	uc010rud.1	+	4	643	c.643G>A	c.(643-645)GTG>ATG	p.V215M		NM_001080486	NP_001073955	A6ND01	FOLR4_HUMAN	folate receptor 4 (delta) homolog	222						extracellular region	folic acid binding|receptor activity			ovary(1)	1						CAATGTGGCCGTGGCCCGCCT	0.597													42	191					0	0	0	0	A	94040769	A	A	94040769	3	1	302	1	0	0	0	0	1	0	0	0	6016	1145	40	1	657	1	FOLR4	11	94040769	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	23818066	94040769	40965747	42	55493											
MMP12	4321	broad.mit.edu	37	chr11	102743642	102743642	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	acgggcccccctggcatttcCctgaaatgatggacatcggg	8	8	12	13	2	0	2	0	2	0	0	2	3	1	3	4	4	0	1	4	4	1	1			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr11:102743642C>A	uc001phk.2	-	2	348	c.303G>T	c.(301-303)AGG>AGT	p.R101S		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	101					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	CTGGCATTTCCCTGAAATGAT	0.507													8	25					2.17888e-05	2.25151e-05	1	0	A	102743642	A	A	102743642	3	1	302	1	0	0	0	0	1	0	0	0	9704	622	22	4	1144	4	MMP12	11	102743642	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	8702873	102743642	32262874	43	55494											
C11orf61	79684	broad.mit.edu	37	chr11	124637180	124637180	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	acaaatttgatgtagatggaTttgggggaaactccgggatc	12	11	13	5	1	0	2	0	1	0	1	2	5	1	5	1	4	1	1	1	4	3	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr11:124637180T>C	uc001qba.1	-	4	1595	c.1572A>G	c.(1570-1572)AAA>AAG	p.K524K	C11orf61_uc001qaz.1_Silent_p.K472K|C11orf61_uc010sap.1_Silent_p.K244K|C11orf61_uc001qay.1_Silent_p.K294K	NM_024631	NP_078907	Q6P1R3	CK061_HUMAN	hypothetical protein LOC79684	524											0	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0079)		TGTAGATGGATTTGGGGGAAA	0.408													24	50					0	0	0	0	C	124637180	C	C	124637180	2	2	302	1	0	0	0	0	0	0	0	1	1659	1490	52	5		5	C11orf61	11	124637180	Silent	SNP	T	TCGA-HD-7917-01A-11D-2229-08	21893538	124637180	10369336	44	55495											
MLL2	8085	broad.mit.edu	37	chr12	49418616	49418617	+	Frame_Shift_Ins	INS	-	A	A																															tcagctatgcgaagcacggcINSatgcaccgtcagcccaaaga																										TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr12:49418616_49418617insA	uc001rta.3	-	49	15897_15898	c.15897_15898insT	c.(15895-15900)CATGCCfs	p.H5299fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5299_5300	FYR C-terminal.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CGAAGCACGGCATGCACCGTCA	0.559			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---								A	49418617	A	A	49418616	7	5	302	1	0	1	1	0	0	0	0	0	9674	710	25	0	739	0	MLL2	12	49418616	Frame_Shift_Ins	INS	-	TCGA-HD-7917-01A-11D-2229-08		49418616	84433279	45	55496											
MYBPC1	4604	broad.mit.edu	37	chr12	102064187	102064187	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	aatctggttatacctttccaGgtaagagttcaagggtcgct	10	13	10	8	1	2	1	1	0	1	1	4	1	3	1	2	3	1	4	2	3	5	5			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr12:102064187G>C	uc001tii.2	+	23	2694	c.2592G>C	c.(2590-2592)CAG>CAC	p.Q864H	MYBPC1_uc001tig.2_Missense_Mutation_p.Q871H|MYBPC1_uc010svq.1_Missense_Mutation_p.Q833H|MYBPC1_uc001tih.2_Missense_Mutation_p.Q871H|MYBPC1_uc001tij.2_Missense_Mutation_p.Q846H|MYBPC1_uc010svr.1_Missense_Mutation_p.Q846H|MYBPC1_uc010svs.1_Missense_Mutation_p.Q864H|MYBPC1_uc010svt.1_Missense_Mutation_p.Q834H|MYBPC1_uc010svu.1_Missense_Mutation_p.Q827H|MYBPC1_uc001tik.2_Missense_Mutation_p.Q820H|MYBPC1_uc001til.2_5'UTR|MYBPC1_uc001tim.2_5'UTR	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	864	Ig-like C2-type 6.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						TACCTTTCCAGGTAAGAGTTC	0.403													15	56					0	0	0	0	C	102064187	C	C	102064187	3	2	302	1	0	0	0	0	1	0	0	0	10064	1014	35	4	2765	4	MYBPC1	12	102064187	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	52645571	102064187	31787708	46	55497											
HVCN1	84329	broad.mit.edu	37	chr12	111099133	111099133	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcctcctcctcctcttCattctcccatttcttgtagt	3	18	2	18	0	4	0	1	0	3	0	10	0	9	0	6	0	0	1	6	0	1	5			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr12:111099133C>A	uc001trs.1	-	4	307	c.142G>T	c.(142-144)GAA>TAA	p.E48*	HVCN1_uc001trq.1_Nonsense_Mutation_p.E48*|HVCN1_uc001trt.1_Nonsense_Mutation_p.E48*|HVCN1_uc010syd.1_Nonsense_Mutation_p.E28*	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	48	Cytoplasmic (Potential).|Poly-Glu.				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						tcctcctcttcattctccCAT	0.517													11	30					6.40141e-05	6.5421e-05	1	0	A	111099133	A	A	111099133	4	1	302	1	0	0	0	0	0	1	0	0	7501	835	29	2	699	2	HVCN1	12	111099133	Nonsense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	9034946	111099133	22752762	47	55498											
FAM101A	144347	broad.mit.edu	37	chr12	124798924	124798926	+	In_Frame_Del	DEL	CAT	-	-																															ctgcgcttccgcagcaccacCatcatcttccccaagcatgc																										TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr12:124798924_124798926delCAT	uc001ugd.1	+	3	504_506	c.261_263delCAT	c.(259-264)ACCATC>ACC	p.I89del	FAM101A_uc001uge.1_In_Frame_Del_p.I89del	NM_181709	NP_859060	Q6ZTI6	F101A_HUMAN	hypothetical protein LOC144347	170											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		GCAGCACCACCATCATCTTCCCC	0.685													---	---	---								-	124798926	-	-	124798924	7	5	302	1	0	1	0	1	0	0	0	0	5408	581	21	0	267	0	FAM101A	12	124798924	In_Frame_Del	DEL	CAT	TCGA-HD-7917-01A-11D-2229-08	13699791	124798924	9052971	48	55499											
ZNF219	51222	broad.mit.edu	37	chr14	21558826	21558828	+	In_Frame_Del	DEL	GGG	-	-																															gggcggggacgcgtcagcctGgggtggccggcggcccctag																										TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr14:21558826_21558828delGGG	uc001vzr.2	-	5	2457_2459	c.2036_2038delCCC	c.(2035-2040)CCCCAG>CAG	p.P679del	ZNF219_uc001vzs.2_In_Frame_Del_p.P679del|ZNF219_uc010aik.1_In_Frame_Del_p.P679del	NM_016423	NP_057507	Q9P2Y4	ZN219_HUMAN	zinc finger protein 219	679					negative regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|histamine receptor activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)	1	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;9.86e-11)|Epithelial(56;1.27e-08)|all cancers(55;6.06e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GCGTCAGCCTGGGGTGGCCGGCG	0.7													---	---	---								-	21558828	-	-	21558826	7	5	302	1	0	1	0	1	0	0	0	0	17840	1357	47	0	134	0	ZNF219	14	21558826	In_Frame_Del	DEL	GGG	TCGA-HD-7917-01A-11D-2229-08		21558826	85790714	49	55500											
GRINL1A	81488	broad.mit.edu	37	chr15	58001429	58001429	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggtgaacaacagtcagaaGaaaacgcaagtactaagaac	21	4	9	7	1	1	4	1	1	0	3	1	4	1	4	0	1	5	2	0	1	10	2			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr15:58001429G>C	uc002aet.3	+	2	771	c.631G>C	c.(631-633)GAA>CAA	p.E211Q	GCOM1_uc002aem.2_Intron|GCOM1_uc002aeq.2_Intron|GCOM1_uc002aen.2_Intron|GCOM1_uc010bfy.2_Intron|GCOM1_uc002aeo.2_Intron|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_Intron|GRINL1A_uc002aes.2_5'UTR|GRINL1A_uc002aev.1_3'UTR|GRINL1A_uc010ugu.1_RNA|GRINL1A_uc002aeu.3_Missense_Mutation_p.E54Q	NM_015532	NP_056347	P0CAP1	GCOM1_HUMAN	glutamate receptor, ionotropic, N-methyl	293	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band					0				all cancers(107;0.0697)|GBM - Glioblastoma multiforme(80;0.12)		ACAGTCAGAAGAAAACGCAAG	0.458													10	25					0	0	0	0	C	58001429	C	C	58001429	3	2	302	1	0	0	0	0	1	0	0	0	6825	943	33	2	637	2	GRINL1A	15	58001429	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08		58001429	44529963	50	55501											
NARG2	79664	broad.mit.edu	37	chr15	60758824	60758824	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacgggcatcatcagaaagcAtattataatcctgcgcacat	14	9	8	10	2	2	1	2	0	0	1	3	2	3	1	1	1	2	3	1	1	4	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr15:60758824A>C	uc002agp.2	-	5	732	c.497T>G	c.(496-498)ATG>AGG	p.M166R	NARG2_uc002ago.2_Missense_Mutation_p.M29R|NARG2_uc010bgk.2_Missense_Mutation_p.M166R|NARG2_uc002agr.1_Missense_Mutation_p.M166R	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	166						nucleus				ovary(1)|lung(1)	2						ATCAGAAAGCATATTATAATC	0.348													19	46					0	0	0	0	C	60758824	C	C	60758824	3	2	302	1	0	0	0	0	1	0	0	0	10222	217	8	5	2499	5	NARG2	15	60758824	Missense_Mutation	SNP	A	TCGA-HD-7917-01A-11D-2229-08	2757395	60758824	41772568	51	55502											
PIGQ	9091	broad.mit.edu	37	chr16	624737	624737	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgttggccagcctgctgtcGctggtctcagctgtcagtgc	3	12	13	13	1	2	0	2	0	1	0	4	0	2	0	2	2	4	4	2	2	0	1			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr16:624737G>A	uc002cho.2	+	2	765	c.663G>A	c.(661-663)TCG>TCA	p.S221S	PIGQ_uc010bqw.2_Silent_p.S221S|PIGQ_uc002chm.2_Silent_p.S221S|PIGQ_uc002chn.2_Silent_p.S221S|PIGQ_uc010uui.1_Silent_p.S235S	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	221	Leu-rich.				C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				GCCTGCTGTCGCTGGTCTCAG	0.662													5	19					0	0	0	0	A	624737	A	A	624737	2	1	302	1	0	0	0	0	0	0	0	1	11951	1074	38	1		1	PIGQ	16	624737	Silent	SNP	G	TCGA-HD-7917-01A-11D-2229-08		624737	89730016	52	55503											
NAGPA	51172	broad.mit.edu	37	chr16	5083632	5083632	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggaggcggaggccaactctCgtgctcgcggttgccggcgc	4	6	18	13	6	1	0	0	0	1	0	3	2	1	2	2	6	3	2	2	6	1	1			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr16:5083632C>T	uc002cyg.2	-	2	205	c.184G>A	c.(184-186)GAG>AAG	p.E62K	ALG1_uc002cyj.2_5'Flank|NAGPA_uc002cyf.2_5'UTR|NAGPA_uc002cyh.2_RNA|NAGPA_uc002cyi.2_5'UTR|NAGPA_uc010uxx.1_Missense_Mutation_p.E62K	NM_016256	NP_057340	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester	62	Lumenal (Potential).				carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity				0					N-Acetyl-D-glucosamine(DB00141)	GGCCAACTCTCGTGCTCGCGG	0.756													6	21					0	0	0	0	T	5083632	T	T	5083632	3	4	302	1	0	0	0	0	1	0	0	0	10197	893	31	1	1399	1	NAGPA	16	5083632	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	4458895	5083632	85271121	53	55504											
SRCAP	10847	broad.mit.edu	37	chr16	30735404	30735404	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cctgtcctggtgccagcttcGgctctggccagtccttttcc	2	13	10	16	1	1	0	0	0	1	0	5	0	4	0	6	3	2	2	6	3	0	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr16:30735404G>A	uc002dze.1	+	25	5044	c.4659G>A	c.(4657-4659)TCG>TCA	p.S1553S	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.S1348S|SRCAP_uc010bzz.1_Silent_p.S1123S	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1553	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGCCAGCTTCGGCTCTGGCCA	0.592													10	18					0	0	0	0	A	30735404	A	A	30735404	2	1	302	1	0	0	0	0	0	0	0	1	15201	1103	39	1		1	SRCAP	16	30735404	Silent	SNP	G	TCGA-HD-7917-01A-11D-2229-08	25651772	30735404	59619349	54	55505											
PHKB	5257	broad.mit.edu	37	chr16	47531396	47531396	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	agttggaccattattacagaAttggtgagtaaaacctgagg	14	11	11	5	0	0	3	0	2	0	1	0	4	0	4	2	3	2	2	2	3	5	5			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr16:47531396A>T	uc002eev.3	+	2	215	c.163A>T	c.(163-165)ATT>TTT	p.I55F	PHKB_uc010vgi.1_Missense_Mutation_p.I48F|PHKB_uc002eeu.3_Missense_Mutation_p.I48F	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	55					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				TTATTACAGAATTGGTGAGTA	0.353													5	19					0	0	0	0	T	47531396	T	T	47531396	3	4	302	1	0	0	0	0	1	0	0	0	11900	101	4	5	228	5	PHKB	16	47531396	Missense_Mutation	SNP	A	TCGA-HD-7917-01A-11D-2229-08	16795992	47531396	42823357	55	55506											
NUDT21	11051	broad.mit.edu	37	chr16	56481891	56481891	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgtaccaaaagtataattggTaagagggtacctgtgatccg	13	11	11	6	1	0	2	0	1	0	1	1	2	1	2	3	2	2	4	3	2	7	6			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr16:56481891T>C	uc002eja.2	-	2	274	c.127A>G	c.(127-129)ACC>GCC	p.T43A	NUDT21_uc002eiz.2_5'UTR	NM_007006	NP_008937	O43809	CPSF5_HUMAN	cleavage and polyadenylation specific factor 5	43	Necessary for RNA-binding.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	centrosome|mRNA cleavage factor complex|paraspeckles	AU-rich element binding|histone deacetylase binding|hydrolase activity|mRNA binding|protein homodimerization activity				0						GTATAATTGGTAAGAGGGTAC	0.388													8	12					0	0	0	0	C	56481891	C	C	56481891	3	2	302	1	0	0	0	0	1	0	0	0	10792	1638	57	5	580	5	NUDT21	16	56481891	Missense_Mutation	SNP	T	TCGA-HD-7917-01A-11D-2229-08	8950495	56481891	33872862	56	55507											
ZDHHC1	29800	broad.mit.edu	37	chr16	67434868	67434868	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	acacacactcacacatccacGttgcacaagttgcagtgcag	13	7	7	14	1	1	0	1	0	0	0	2	0	2	0	1	0	3	5	1	0	1	2	rs34689150	byFrequency	TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr16:67434868G>A	uc010vjm.1	-	4	724	c.420C>T	c.(418-420)AAC>AAT	p.N140N		NM_013304	NP_037436	Q8WTX9	ZDHC1_HUMAN	zinc finger, DHHC-type containing 1	140	DHHC-type.					integral to membrane	DNA binding|zinc ion binding				0		Ovarian(137;0.223)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0178)|all cancers(182;5.71e-53)|Epithelial(162;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(108;1.53e-29)|Kidney(780;4.37e-05)|BRCA - Breast invasive adenocarcinoma(181;5.8e-05)|GBM - Glioblastoma multiforme(240;0.0022)		ACACATCCACGTTGCACAAGT	0.592													16	85					0	0	0	0	A	67434868	A	A	67434868	2	1	302	1	0	0	0	0	0	0	0	1	17667	1136	40	1		1	ZDHHC1	16	67434868	Silent	SNP	G	TCGA-HD-7917-01A-11D-2229-08	10952977	67434868	22919885	57	55508											
C17orf85	55421	broad.mit.edu	37	chr17	3719527	3719527	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gttaccaattcggtttttgaTattgcttgaagatacactat	11	17	7	6	1	0	3	0	2	0	1	1	3	0	3	1	1	3	3	1	1	6	9			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr17:3719527T>A	uc010ckl.1	-	11	1371	c.1348A>T	c.(1348-1350)ATC>TTC	p.I450F	C17orf85_uc002fwr.2_Missense_Mutation_p.I160F|C17orf85_uc002fwq.2_Missense_Mutation_p.I170F	NM_001114118	NP_001107590	Q53F19	CQ085_HUMAN	ELG protein isoform a	450							nucleotide binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		CGGTTTTTGATATTGCTTGAA	0.448													11	30					0	0	0	0	A	3719527	A	A	3719527	3	1	302	1	0	0	0	0	1	0	0	0	1896	1406	49	5	526	5	C17orf85	17	3719527	Missense_Mutation	SNP	T	TCGA-HD-7917-01A-11D-2229-08		3719527	77475683	58	55509											
TP53	7157	broad.mit.edu	37	chr17	7574034	7574034	+	Splice_Site	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagcgctcacgcccacggatCtgcagcaacagaggaggggg	11	3	15	12	3	2	1	1	0	1	1	2	3	2	3	1	4	4	3	1	4	2	0			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr17:7574034C>A	uc002gim.2	-	10	1188	c.994_splice	c.e10-1	p.I332_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_Splice_Site|TP53_uc010cng.1_Splice_Site|TP53_uc002gii.1_Splice_Site_p.I200_splice|TP53_uc010cnh.1_Splice_Site|TP53_uc010cni.1_Splice_Site|TP53_uc002gij.2_Splice_Site_p.I332_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(4)|p.I332fs*49(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCACGGATCTGCAGCAACA	0.403		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	19					2.17888e-05	2.25151e-05	1	0	A	7574034	A	A	7574034	5	1	302	1	0	0	0	0	0	0	1	0	16448	927	32	2	196	2	TP53	17	7574034	Splice_Site	SNP	C	TCGA-HD-7917-01A-11D-2229-08	3854507	7574034	73621176	59	55510											
EPX	8288	broad.mit.edu	37	chr17	56274399	56274399	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acaagaacagagtccgcaacCagatcaacgcgctcacctcc	14	4	7	16	3	2	3	2	0	0	3	4	3	4	3	4	0	3	2	4	0	4	0			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr17:56274399C>A	uc002ivq.2	+	7	987	c.901C>A	c.(901-903)CAG>AAG	p.Q301K		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	301					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						AGTCCGCAACCAGATCAACGC	0.602													48	149					1.65492e-34	1.87692e-34	1	0	A	56274399	A	A	56274399	3	1	302	1	0	0	0	0	1	0	0	0	5224	595	21	4	927	4	EPX	17	56274399	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	48700365	56274399	24920811	60	55511											
ACE	1636	broad.mit.edu	37	chr17	61574511	61574511	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	cgctcagctcgctcagaaggGcccctcccagacagcggccg	7	4	12	18	4	2	2	2	0	0	2	4	2	3	2	4	2	2	3	4	2	1	0			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr17:61574511G>A	uc002jau.1	+	25	3727	c.3705G>A	c.(3703-3705)GGG>GGA	p.G1235G	ACE_uc002jav.1_Silent_p.G661G|ACE_uc010ddv.1_Silent_p.G462G|ACE_uc010wpj.1_Silent_p.G620G|ACE_uc002jaw.1_Intron|ACE_uc010wpk.1_Silent_p.G440G	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	1235	Extracellular (Potential).				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GCTCAGAAGGGCCCCTCCCAG	0.552													6	14					0	0	0	0	A	61574511	A	A	61574511	2	1	302	1	0	0	0	0	0	0	0	1	136	1190	42	4		4	ACE	17	61574511	Silent	SNP	G	TCGA-HD-7917-01A-11D-2229-08	5300112	61574511	19620699	61	55512											
ABCA6	23460	broad.mit.edu	37	chr17	67080490	67080490	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcccaggaggctcagcacaaAacacaactgcaatgtagaaa	17	5	8	11	0	1	1	1	0	0	1	2	2	2	2	1	2	4	4	1	2	6	1			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr17:67080490A>T	uc002jhw.1	-	34	4442	c.4267T>A	c.(4267-4269)TTT>ATT	p.F1423I		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1423	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					CTCAGCACAAAACACAACTGC	0.517													58	144					0	0	0	0	T	67080490	T	T	67080490	3	4	302	1	0	0	0	0	1	0	0	0	36	14	1	5	610	5	ABCA6	17	67080490	Missense_Mutation	SNP	A	TCGA-HD-7917-01A-11D-2229-08	5505979	67080490	14114720	62	55513											
DLGAP1	9229	broad.mit.edu	37	chr18	3534609	3534609	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gttggatcgagtgaacctgcGgaagcttgggagaatagaaa	13	8	15	5	2	0	3	0	1	0	2	1	7	0	5	1	3	3	2	1	3	5	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr18:3534609G>C	uc002kmf.2	-	7	2129	c.2062C>G	c.(2062-2064)CGC>GGC	p.R688G	DLGAP1_uc010wyz.1_Missense_Mutation_p.R688G|DLGAP1_uc002kme.1_Missense_Mutation_p.R386G|DLGAP1_uc010dkn.2_Missense_Mutation_p.R396G|DLGAP1_uc010wyw.1_Missense_Mutation_p.R394G|DLGAP1_uc010wyx.1_Missense_Mutation_p.R410G|DLGAP1_uc010wyy.1_Missense_Mutation_p.R372G|DLGAP1_uc002kmg.2_Missense_Mutation_p.R386G	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	688					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GTGAACCTGCGGAAGCTTGGG	0.303													4	16					0	0	0	0	C	3534609	C	C	3534609	3	2	302	1	0	0	0	0	1	0	0	0	4581	1116	39	3	887	3	DLGAP1	18	3534609	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08		3534609	74542639	63	55514											
STARD6	147323	broad.mit.edu	37	chr18	51855808	51855808	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	ttctggaaaatccacactttTagctaagagattttaaaaaa	17	13	5	6	0	1	1	0	0	1	1	2	3	2	2	1	1	1	1	1	1	7	6			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr18:51855808T>C	uc010xdt.1	-	5	388	c.388A>G	c.(388-390)AAA>GAA	p.K130E		NM_139171	NP_631910	P59095	STAR6_HUMAN	START domain containing protein 6	130	START.				lipid transport		lipid binding			ovary(1)	1				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		TCCACACTTTTAGCTAAGAGA	0.313													27	45					0	0	0	0	C	51855808	C	C	51855808	3	2	302	1	0	0	0	0	1	0	0	0	15327	1763	61	5	281	5	STARD6	18	51855808	Missense_Mutation	SNP	T	TCGA-HD-7917-01A-11D-2229-08	48321199	51855808	26221440	64	55515											
MCOLN1	57192	broad.mit.edu	37	chr19	7589892	7589892	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccgggtatgggacccaggCggggccttcaccggcccctc	4	5	14	18	3	1	0	1	0	0	0	2	1	1	1	7	6	0	1	7	6	1	2			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr19:7589892C>T	uc002mgo.2	+	2	202	c.77C>T	c.(76-78)GCG>GTG	p.A26V	MCOLN1_uc010dvh.1_Missense_Mutation_p.A26V|MCOLN1_uc002mgp.2_5'UTR	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	26					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						GGGACCCAGGCGGGGCCTTCA	0.622													6	16					0	0	0	0	T	7589892	T	T	7589892	3	4	302	1	0	0	0	0	1	0	0	0	9448	768	27	1	83	1	MCOLN1	19	7589892	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08		7589892	51539091	65	55516											
LASS4	79603	broad.mit.edu	37	chr19	8321561	8321561	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgggtttctacctctcactGctaatcaggctgccctttga	6	14	8	13	0	3	1	2	1	2	0	4	1	3	1	2	2	3	3	2	2	2	4			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr19:8321561G>A	uc002mjg.2	+	8	899	c.579G>A	c.(577-579)CTG>CTA	p.L193L	LASS4_uc002mjh.2_Silent_p.L142L|LASS4_uc002mji.2_Silent_p.L29L|LASS4_uc010dvz.2_Silent_p.L193L	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	LAG1 homolog, ceramide synthase 4	193	TLC.|Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(1)	1						ACCTCTCACTGCTAATCAGGC	0.577													23	43					0	0	0	0	A	8321561	A	A	8321561	2	1	302	1	0	0	0	0	0	0	0	1	8681	1306	46	4		4	LASS4	19	8321561	Silent	SNP	G	TCGA-HD-7917-01A-11D-2229-08	731669	8321561	50807422	66	55517											
ANGPTL6	83854	broad.mit.edu	37	chr19	10205476	10205476	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agggtgacctgcaggcatggGagaagccatgggctcctgct	8	7	16	10	0	0	2	0	1	0	1	1	3	1	2	3	4	3	4	3	4	1	0			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr19:10205476G>A	uc002mmx.1	-	3	839	c.721C>T	c.(721-723)CCC>TCC	p.P241S	ANGPTL6_uc002mmy.1_Missense_Mutation_p.P241S	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	241					angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			GCAGGCATGGGAGAAGCCATG	0.587													32	87					0	0	0	0	A	10205476	A	A	10205476	3	1	302	1	0	0	0	0	1	0	0	0	618	1174	41	2	707	2	ANGPTL6	19	10205476	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	1883915	10205476	48923507	67	55518											
SLC44A2	57153	broad.mit.edu	37	chr19	10745693	10745693	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcattatcatcttgctgctCatctttctccggaagagaat	9	15	7	10	1	6	1	3	0	3	1	7	3	6	2	1	1	2	2	1	1	3	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr19:10745693C>T	uc002mpf.2	+	12	1138	c.999C>T	c.(997-999)CTC>CTT	p.L333L	SLC44A2_uc002mpe.3_Silent_p.L331L|SLC44A2_uc002mpg.1_Silent_p.L53L|SLC44A2_uc002mph.2_5'Flank	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	333	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	TCTTGCTGCTCATCTTTCTCC	0.557													56	181					0	0	0	0	T	10745693	T	T	10745693	2	4	302	1	0	0	0	0	0	0	0	1	14700	813	29	2		2	SLC44A2	19	10745693	Silent	SNP	C	TCGA-HD-7917-01A-11D-2229-08	540217	10745693	48383290	68	55519											
AXL	558	broad.mit.edu	37	chr19	41726618	41726618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggggactcacgggcacccttCggtgtcagctccaggttcag	6	8	14	13	2	3	0	3	0	0	0	5	1	4	1	2	5	1	3	2	5	0	2			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr19:41726618C>T	uc010ehj.2	+	2	353	c.163C>T	c.(163-165)CGG>TGG	p.R55W	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Missense_Mutation_p.R55W|AXL_uc010ehk.2_Missense_Mutation_p.R55W	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	55	Extracellular (Potential).|Interaction with GAS6.|Ig-like C2-type 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						GGGCACCCTTCGGTGTCAGCT	0.632													5	23					0	0	0	0	T	41726618	T	T	41726618	3	4	302	1	0	0	0	0	1	0	0	0	1240	875	31	1	169	1	AXL	19	41726618	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	30980925	41726618	17402365	69	55520											
RPL18	6141	broad.mit.edu	37	chr19	49118662	49118663	+	Frame_Shift_Ins	INS	-	AA	AA																															ctcggctggcccgtcggcctINSctggcacgctcgaacttccg																										TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr19:49118662_49118663insAA	uc002pjq.1	-	7	566_567	c.533_534insTT	c.(532-534)AGAfs	p.R178fs	FAM83E_uc002pjn.2_5'Flank|RPL18_uc002pjp.1_Frame_Shift_Ins_p.R126fs	NM_000979	NP_000970	Q07020	RL18_HUMAN	ribosomal protein L18	178					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.89e-05)|all cancers(93;0.00011)|GBM - Glioblastoma multiforme(486;0.0061)|Epithelial(262;0.0154)		CCCGTCGGCCTCTGGCACGCTC	0.559													---	---	---								AA	49118663	AA	AA	49118662	7	5	302	1	0	1	1	0	0	0	0	0	13629	1548	54	0	36	0	RPL18	19	49118662	Frame_Shift_Ins	INS	-	TCGA-HD-7917-01A-11D-2229-08	7392044	49118662	10010321	70	55521											
ZNF480	147657	broad.mit.edu	37	chr19	52825507	52825507	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctctagcaaatcattggaGaatttatactggagagaagc	15	11	9	6	0	2	2	1	0	1	2	3	5	2	3	0	2	3	1	0	2	6	5			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr19:52825507G>T	uc010ydl.1	+	5	1074	c.1004G>T	c.(1003-1005)AGA>ATA	p.R335I	ZNF480_uc002pyv.2_Missense_Mutation_p.R258I|ZNF480_uc010ydm.1_Missense_Mutation_p.R292I|ZNF480_uc010epn.2_Missense_Mutation_p.R166I|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	335	C2H2-type 5; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		AATCATTGGAGAATTTATACT	0.393													9	29					1.12685e-05	1.19088e-05	1	0	T	52825507	T	T	52825507	3	4	302	1	0	0	0	0	1	0	0	0	18002	942	33	2	1018	2	ZNF480	19	52825507	Missense_Mutation	SNP	G	TCGA-HD-7917-01A-11D-2229-08	3706845	52825507	6303476	71	55522											
ZNF331	55422	broad.mit.edu	37	chr19	54079994	54079994	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	aagagtttacctacagaaaaAaacattcatgaaataagggc	20	8	7	6	0	1	3	1	1	0	2	1	3	1	3	1	1	3	1	1	1	8	5			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr19:54079994A>T	uc002qbx.1	+	7	1614	c.180A>T	c.(178-180)AAA>AAT	p.K60N	ZNF331_uc002qby.1_Missense_Mutation_p.K60N|ZNF331_uc002qbz.1_Missense_Mutation_p.K60N|ZNF331_uc002qca.1_Missense_Mutation_p.K60N|ZNF331_uc010eqr.1_Missense_Mutation_p.K60N|ZNF331_uc002qcb.1_Missense_Mutation_p.K60N|ZNF331_uc002qcc.1_Missense_Mutation_p.K60N|ZNF331_uc002qcd.1_Missense_Mutation_p.K60N	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	60	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		CTACAGAAAAAAACATTCATG	0.373			T	?	follicular thyroid adenoma								14	18					0	0	0	0	T	54079994	T	T	54079994	3	4	302	1	0	0	0	0	1	0	0	0	17916	11	1	5	190	5	ZNF331	19	54079994	Missense_Mutation	SNP	A	TCGA-HD-7917-01A-11D-2229-08	1254487	54079994	5048989	72	55523											
NLRP5	126206	broad.mit.edu	37	chr19	56539108	56539108	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgctcacaggcctgcacgcCgcttttgtgtttcatcagct	6	12	9	14	3	3	0	3	0	0	0	3	0	3	0	2	1	2	5	2	1	0	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chr19:56539108C>T	uc002qmj.2	+	7	1509	c.1509C>T	c.(1507-1509)GCC>GCT	p.A503A	NLRP5_uc002qmi.2_Silent_p.A484A	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	503	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GCCTGCACGCCGCTTTTGTGT	0.632													9	26					0	0	0	0	T	56539108	T	T	56539108	2	4	302	1	0	0	0	0	0	0	0	1	10534	639	23	1		1	NLRP5	19	56539108	Silent	SNP	C	TCGA-HD-7917-01A-11D-2229-08	2459114	56539108	2589875	73	55524											
GNL3L	54552	broad.mit.edu	37	chrX	54584985	54584985	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gtggatgtctgctcagtggaCcgccgctcagtgctgcagag	6	9	15	11	2	3	1	2	0	1	1	3	3	3	3	2	2	3	4	2	2	0	0	rs141548321	byFrequency	TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chrX:54584985C>T	uc004dth.1	+	15	1702	c.1563C>T	c.(1561-1563)GAC>GAT	p.D521D	GNL3L_uc004dti.2_RNA	NM_019067	NP_061940	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3	521					ribosome biogenesis	nucleolus	GTP binding			ovary(1)	1						GCTCAGTGGACCGCCGCTCAG	0.557													5	14					0	0	0	0	T	54584985	T	T	54584985	2	4	302	1	0	0	0	0	0	0	0	1	6575	506	18	4		4	GNL3L	23	54584985	Silent	SNP	C	TCGA-HD-7917-01A-11D-2229-08		54584985	100685575	74	55525											
MAGT1	84061	broad.mit.edu	37	chrX	77131009	77131009	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcggtggggctttcacaaggCgacggaacttgtctccattc	7	11	12	11	3	2	0	1	0	1	0	5	2	2	1	1	5	1	1	1	5	2	3			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chrX:77131009C>T	uc004fof.2	-	2	346	c.284G>A	c.(283-285)CGC>CAC	p.R95H	MAGT1_uc004fog.3_RNA|MAGT1_uc004ect.3_Missense_Mutation_p.R95H	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	63					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						TTTCACAAGGCGACGGAACTT	0.418													23	97					0	0	0	0	T	77131009	T	T	77131009	3	4	302	1	0	0	0	0	1	0	0	0	9249	768	27	1	855	1	MAGT1	23	77131009	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08	22546024	77131009	78139551	75	55526											
ZFY	7544	broad.mit.edu	37	chrY	2829238	2829238	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttcctgatgacccagactCagttgtaatccaagatgttg	10	13	9	9	0	1	4	1	2	0	2	3	4	3	4	3	0	0	4	3	0	2	4			TCGA-HD-7917-01A-11D-2229-08	TCGA-HD-7917-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	451948c9-3d16-4771-b006-28b98580db2c	778ebe8c-c5a3-48df-b092-2bff7b95c8ba	g.chrY:2829238C>T	uc004fqj.2	+	3	506	c.185C>T	c.(184-186)TCA>TTA	p.S62L	ZFY_uc010nwd.1_Missense_Mutation_p.S62L|ZFY_uc011nan.1_Intron|ZFY_uc010nwe.2_Missense_Mutation_p.S36L	NM_003411	NP_003402	P08048	ZFY_HUMAN	zinc finger protein, Y-linked isoform 1	62					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GACCCAGACTCAGTTGTAATC	0.373													13	47					0	0	0	0	T	2829238	T	T	2829238	3	4	302	1	0	0	0	0	1	0	0	0	17729	838	29	2	191	2	ZFY	24	2829238	Missense_Mutation	SNP	C	TCGA-HD-7917-01A-11D-2229-08		2829238	56544328	76	55527											
RNF207	388591	broad.mit.edu	37	chr1	6267454	6267454	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcagacaccagacggtgctGaagggtcccagcgggctccc	8	5	14	14	2	0	3	0	1	0	2	2	3	2	3	3	3	3	3	3	3	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:6267454G>A	uc001amg.2	+	3	381	c.207G>A	c.(205-207)CTG>CTA	p.L69L	RNF207_uc001amf.1_Silent_p.L69L|RNF207_uc001amh.2_5'Flank|RNF207_uc010nzp.1_5'Flank	NM_207396	NP_997279	Q6ZRF8	RN207_HUMAN	ring finger protein 207	69						intracellular	zinc ion binding				0	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		AGACGGTGCTGAAGGGTCCCA	0.672													8	13					0	0	0	0	A	6267454	A	A	6267454	2	1	303	1	0	0	0	0	0	0	0	1	13539	1277	45	2		2	RNF207	1	6267454	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08		6267454	242983167	1	55528											
CASZ1	54897	broad.mit.edu	37	chr1	10725203	10725203	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tgccccgtccgaatccttctCctccagggcaccgccgtcct	4	9	8	20	4	1	0	0	0	1	0	6	1	5	0	9	1	1	1	9	1	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:10725203C>G	uc001aro.2	-	5	762	c.442G>C	c.(442-444)GAG>CAG	p.E148Q	CASZ1_uc001arp.1_Missense_Mutation_p.E148Q|CASZ1_uc009vmx.2_Missense_Mutation_p.E172Q	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GAATCCTTCTCCTCCAGGGCA	0.682													13	20					0	0	0	0	G	10725203	G	G	10725203	3	3	303	1	0	0	0	0	1	0	0	0	2697	864	30	2	4909	2	CASZ1	1	10725203	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4457749	10725203	238525418	2	55529											
MTOR	2475	broad.mit.edu	37	chr1	11318648	11318648	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagtagactcctcttgactCatctgcaaaagaagatataa	15	10	7	9	1	3	4	1	1	2	3	4	5	4	4	1	0	1	2	1	0	6	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:11318648C>A	uc001asd.2	-	3	286	c.165G>T	c.(163-165)ATG>ATT	p.M55I		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	55					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CCTCTTGACTCATCTGCAAAA	0.428													11	33					1.58986e-06	1.62126e-06	1	0	A	11318648	A	A	11318648	3	1	303	1	0	0	0	0	1	0	0	0	10007	826	29	2	7708	2	MTOR	1	11318648	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	593445	11318648	237931973	3	55530											
MAD2L2	10459	broad.mit.edu	37	chr1	11736195	11736195	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgagacaacagcgagtctGagctgggagtgagaggaggt	12	6	17	6	1	1	3	0	3	1	2	1	8	1	5	0	3	3	1	0	3	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:11736195G>C	uc001asp.2	-	6	523	c.335C>G	c.(334-336)TCA>TGA	p.S112*	MAD2L2_uc009vnc.2_Nonsense_Mutation_p.S112*|MAD2L2_uc001asq.3_Nonsense_Mutation_p.S112*	NM_006341	NP_006332	Q9UI95	MD2L2_HUMAN	MAD2 homolog	112	Mediates interaction with REV1 and REV3L and homodimerization.|HORMA.				cell division|DNA damage response, signal transduction resulting in transcription|double-strand break repair|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription, DNA-dependent|regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleoplasm|spindle|zeta DNA polymerase complex	JUN kinase binding				0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CAGCGAGTCTGAGCTGGGAGT	0.622								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					7	18					0	0	0	0	C	11736195	C	C	11736195	4	2	303	1	0	0	0	0	0	1	0	0	9201	1294	45	2	316	2	MAD2L2	1	11736195	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	417547	11736195	237514426	4	55531											
KIAA2013	90231	broad.mit.edu	37	chr1	11983377	11983377	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcatggtggcgtgcccgctGaagcagtgatcttcatagtt	7	12	13	9	2	2	2	1	2	1	0	2	2	2	2	1	2	3	4	1	2	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:11983377G>A	uc001atk.2	-	2	1397	c.1203C>T	c.(1201-1203)TTC>TTT	p.F401F	KIAA2013_uc001atl.1_Silent_p.F401F	NM_138346	NP_612355	Q8IYS2	K2013_HUMAN	hypothetical protein LOC90231 precursor	401	Extracellular (Potential).					integral to membrane				ovary(1)	1	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CGTGCCCGCTGAAGCAGTGAT	0.647													16	39					0	0	0	0	A	11983377	A	A	11983377	2	1	303	1	0	0	0	0	0	0	0	1	8306	1281	45	2		2	KIAA2013	1	11983377	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	247182	11983377	237267244	5	55532											
VPS13D	55187	broad.mit.edu	37	chr1	12445358	12445358	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaaaagcagccgttcatatGaagtggatgaacttcctgtc	12	10	11	8	1	1	2	1	2	0	0	3	4	2	4	2	2	3	2	2	2	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:12445358G>A	uc001atv.2	+	59	11551	c.11410G>A	c.(11410-11412)GAA>AAA	p.E3804K	VPS13D_uc001atw.2_Missense_Mutation_p.E3779K|VPS13D_uc001atx.2_Missense_Mutation_p.E2991K|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3803					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCGTTCATATGAAGTGGATGA	0.373													9	24					0	0	0	0	A	12445358	A	A	12445358	3	1	303	1	0	0	0	0	1	0	0	0	17260	1291	45	2	11640	2	VPS13D	1	12445358	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	461981	12445358	236805263	6	55533											
TMEM51	55092	broad.mit.edu	37	chr1	15546088	15546088	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	actgaaaccgctgaaagttcGaaggattaaatctgaaaagc	17	8	9	7	2	1	3	0	3	1	0	2	5	1	4	1	1	2	2	1	1	7	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:15546088G>A	uc001avw.3	+	4	1130	c.611G>A	c.(610-612)CGA>CAA	p.R204Q	TMEM51_uc010obk.1_Missense_Mutation_p.R204Q|TMEM51_uc001avz.2_3'UTR|TMEM51_uc001avy.2_Missense_Mutation_p.R204Q|TMEM51_uc001avx.2_Missense_Mutation_p.R204Q	NM_001136216	NP_001129688	Q9NW97	TMM51_HUMAN	transmembrane protein 51	204						integral to membrane					0		Renal(390;0.00145)|Breast(348;0.00186)|Colorectal(325;0.00215)|all_lung(284;0.00459)|Lung NSC(340;0.0104)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;2.07e-06)|COAD - Colon adenocarcinoma(227;7.14e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000175)|KIRC - Kidney renal clear cell carcinoma(229;0.00141)|STAD - Stomach adenocarcinoma(313;0.00644)|READ - Rectum adenocarcinoma(331;0.0751)		CTGAAAGTTCGAAGGATTAAA	0.537													17	32					0	0	0	0	A	15546088	A	A	15546088	3	1	303	1	0	0	0	0	1	0	0	0	16243	1058	37	1	617	1	TMEM51	1	15546088	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3100730	15546088	233704533	7	55534											
ZBTB17	7709	broad.mit.edu	37	chr1	16269653	16269653	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	gggcggatgttgtcgtggtgGcgaatatgattggccaactg	7	11	17	6	3	0	1	0	1	0	0	1	3	0	2	1	5	1	1	1	5	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:16269653G>T	uc001axl.3	-	13	1973	c.1734C>A	c.(1732-1734)CGC>CGA	p.R578R	ZBTB17_uc010obq.1_Silent_p.R495R|ZBTB17_uc010obr.1_Silent_p.R578R|ZBTB17_uc010obs.1_Silent_p.R502R	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	578	C2H2-type 10.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCGTGGTGGCGAATATGAT	0.597													24	85					6.12954e-19	6.42211e-19	1	0	T	16269653	T	T	16269653	2	4	303	1	0	0	0	0	0	0	0	1	17594	1190	42	4		4	ZBTB17	1	16269653	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	723565	16269653	232980968	8	55535											
CROCC	9696	broad.mit.edu	37	chr1	17249276	17249276	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gattgtcacccgcaacctctCccagcctgagagcccaggtg	8	7	10	16	1	2	1	1	1	1	1	3	3	2	1	5	1	3	1	5	1	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:17249276C>G	uc001azt.2	+	2	248	c.179C>G	c.(178-180)TCC>TGC	p.S60C	CROCC_uc009voy.1_Intron|CROCC_uc009voz.1_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	60					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CGCAACCTCTCCCAGCCTGAG	0.612													28	100					0	0	0	0	G	17249276	G	G	17249276	3	3	303	1	0	0	0	0	1	0	0	0	3908	855	30	2	185	2	CROCC	1	17249276	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	979623	17249276	232001345	9	55536											
KIAA0090	23065	broad.mit.edu	37	chr1	19559127	19559127	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggatgcctcaccttgtccttCaccagcagggtgcactgtgg	6	10	12	13	0	2	0	2	0	0	0	3	1	3	1	4	3	3	2	4	3	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:19559127C>T	uc001bbo.2	-	15	1816	c.1773G>A	c.(1771-1773)GTG>GTA	p.V591V	KIAA0090_uc001bbp.2_Silent_p.V590V|KIAA0090_uc001bbq.2_Silent_p.V590V|KIAA0090_uc001bbr.2_Silent_p.V569V	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	591	Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		CCTTGTCCTTCACCAGCAGGG	0.483													39	111					0	0	0	0	T	19559127	T	T	19559127	2	4	303	1	0	0	0	0	0	0	0	1	8192	813	29	2		2	KIAA0090	1	19559127	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2309851	19559127	229691494	10	55537											
CDA	978	broad.mit.edu	37	chr1	20915548	20915548	+	Translation_Start_Site	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ccaaggggaggagctgcaatCgtgtctggggccccagccca	8	5	15	13	1	1	0	0	0	1	0	2	2	1	2	4	5	3	2	4	5	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:20915548C>G	uc001bdk.2	+	1	105	c.-74C>G	c.(-76--72)ATCGT>ATGGT		CDA_uc001bdl.2_RNA|CDA_uc009vpv.2_RNA	NM_001785	NP_001776	P32320	CDD_HUMAN	cytidine deaminase						cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	GAGCTGCAATCGTGTCTGGGG	0.662													9	22					0	0	0	0	G	20915548	G	G	20915548	1	3	303	1	0	0	0	0	0	0	0	0	3067	899	31	3		3	CDA	1	20915548	Translation_Start_Site	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1356421	20915548	228335073	11	55538											
LDLRAD2	401944	broad.mit.edu	37	chr1	22142484	22142484	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaatggcaggtgcatcccctCaagcctcgtgtgtgacccct	7	9	11	14	1	1	1	1	1	0	0	3	2	2	1	5	2	2	2	5	2	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:22142484C>T	uc001bfg.1	+	3	747	c.560C>T	c.(559-561)TCA>TTA	p.S187L		NM_001013693	NP_001013715	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain	187	Extracellular (Potential).|LDL-receptor class A.					integral to membrane	receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		TGCATCCCCTCAAGCCTCGTG	0.627													18	53					0	0	0	0	T	22142484	T	T	22142484	3	4	303	1	0	0	0	0	1	0	0	0	8746	838	29	2	570	2	LDLRAD2	1	22142484	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1226936	22142484	227108137	12	55539											
HSPG2	3339	broad.mit.edu	37	chr1	22175513	22175513	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	acctggagcaggcgtagcctCgagccatgcacctgggaggg	8	5	16	12	2	0	0	0	0	0	0	1	3	0	2	4	4	4	3	4	4	1	1	rs146046708		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:22175513C>G	uc001bfj.2	-	58	7498	c.7458G>C	c.(7456-7458)TCG>TCC	p.S2486S	HSPG2_uc009vqd.2_Silent_p.S2487S	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2486	Ig-like C2-type 10.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGCGTAGCCTCGAGCCATGCA	0.647													25	67					0	0	0	0	G	22175513	G	G	22175513	2	3	303	1	0	0	0	0	0	0	0	1	7469	871	31	3		3	HSPG2	1	22175513	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	33029	22175513	227075108	13	55540											
CNKSR1	10256	broad.mit.edu	37	chr1	26510743	26510743	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttgcctttgacctgtcttCaaaccccagtcccggaccca	7	11	6	17	1	2	1	1	1	1	0	3	2	3	2	6	1	2	0	6	1	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:26510743C>T	uc001bln.3	+	11	1044	c.986C>T	c.(985-987)TCA>TTA	p.S329L	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Missense_Mutation_p.S322L|CNKSR1_uc009vsd.2_Missense_Mutation_p.S64L|CNKSR1_uc009vse.2_Missense_Mutation_p.S64L|CNKSR1_uc001blo.2_Missense_Mutation_p.S64L	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	329	Pro-rich.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		GACCTGTCTTCAAACCCCAGT	0.622													41	140					0	0	0	0	T	26510743	T	T	26510743	3	4	303	1	0	0	0	0	1	0	0	0	3621	838	29	2	1007	2	CNKSR1	1	26510743	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4335230	26510743	222739878	14	55541											
SESN2	83667	broad.mit.edu	37	chr1	28599970	28599970	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtcccaggaggagatggaGagccgctttgagctggagaa	11	6	16	8	2	0	4	0	1	0	3	1	8	1	5	2	4	2	2	2	4	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:28599970G>A	uc001bps.2	+	6	1205	c.852G>A	c.(850-852)GAG>GAA	p.E284E		NM_031459	NP_113647	P58004	SESN2_HUMAN	sestrin 2	284					cell cycle arrest	cytoplasm|nucleus				skin(3)|ovary(2)|pancreas(1)|lung(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		AGGAGATGGAGAGCCGCTTTG	0.632													3	9					0	0	0	0	A	28599970	A	A	28599970	2	1	303	1	0	0	0	0	0	0	0	1	14190	933	33	2		2	SESN2	1	28599970	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2089227	28599970	220650651	15	55542											
COL16A1	1307	broad.mit.edu	37	chr1	32158237	32158237	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttctctcccttcgggccttCtgcacactgaacaggggaac	7	10	9	15	1	2	1	0	1	2	0	5	2	3	2	2	3	3	1	2	3	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:32158237C>G	uc001btk.1	-	15	1485	c.1120G>C	c.(1120-1122)GAA>CAA	p.E374Q	COL16A1_uc001btj.1_Missense_Mutation_p.E203Q|COL16A1_uc001btl.3_Missense_Mutation_p.E374Q	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	374	Nonhelical region 10 (NC10).				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TTCGGGCCTTCTGCACACTGA	0.642													12	31					0	0	0	0	G	32158237	G	G	32158237	3	3	303	1	0	0	0	0	1	0	0	0	3688	922	32	2	3922	2	COL16A1	1	32158237	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3558267	32158237	217092384	16	55543											
BAI2	576	broad.mit.edu	37	chr1	32206008	32206008	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaggtgtcagtgacattcctCagaatgtccacagagaagag	14	8	11	8	0	2	4	2	1	0	3	4	5	4	4	2	1	0	0	2	1	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:32206008C>T	uc001btn.2	-	12	2283	c.1929G>A	c.(1927-1929)CTG>CTA	p.L643L	BAI2_uc010ogo.1_Silent_p.L285L|BAI2_uc010ogp.1_Silent_p.L576L|BAI2_uc010ogq.1_Silent_p.L643L|BAI2_uc001bto.2_Silent_p.L643L|BAI2_uc001btq.1_Silent_p.L576L|BAI2_uc010ogr.1_Intron	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	643	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TGACATTCCTCAGAATGTCCA	0.612													9	21					0	0	0	0	T	32206008	T	T	32206008	2	4	303	1	0	0	0	0	0	0	0	1	1301	813	29	2		2	BAI2	1	32206008	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	47771	32206008	217044613	17	55544											
SPOCD1	90853	broad.mit.edu	37	chr1	32257955	32257955	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtagagcaggcggcagttCtgggtgtcccgggccccatg	6	7	17	11	2	1	1	0	0	1	1	2	2	2	1	3	4	1	4	3	4	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:32257955C>T	uc001bts.1	-	15	2881	c.2823G>A	c.(2821-2823)CAG>CAA	p.Q941Q	SPOCD1_uc001btr.1_Silent_p.Q29Q|SPOCD1_uc001btt.2_Silent_p.Q246Q|SPOCD1_uc001btu.2_Silent_p.Q941Q|SPOCD1_uc001btv.2_Silent_p.Q434Q	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	941	SPOC.				transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		GGCGGCAGTTCTGGGTGTCCC	0.647													8	23					0	0	0	0	T	32257955	T	T	32257955	2	4	303	1	0	0	0	0	0	0	0	1	15144	912	32	2		2	SPOCD1	1	32257955	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	51947	32257955	216992666	18	55545											
TXLNA	200081	broad.mit.edu	37	chr1	32660619	32660619	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacaagagggtacaggacctGagtgctggtggccagggctc	10	6	16	9	0	0	2	0	1	0	1	1	3	0	3	2	5	3	3	2	5	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:32660619G>C	uc001bui.2	+	11	1529	c.1464G>C	c.(1462-1464)CTG>CTC	p.L488L	TXLNA_uc001buj.2_Silent_p.L488L	NM_175852	NP_787048	P40222	TXLNA_HUMAN	taxilin	488	Potential.				cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TACAGGACCTGAGTGCTGGTG	0.627													12	34					0	0	0	0	C	32660619	C	C	32660619	2	2	303	1	0	0	0	0	0	0	0	1	16855	1277	45	2		2	TXLNA	1	32660619	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	402664	32660619	216590002	19	55546											
YARS	8565	broad.mit.edu	37	chr1	33272155	33272155	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accacctcagctccagccttCttggaatcgtgctgtgtgac	7	11	9	14	1	2	1	1	1	1	0	4	2	3	2	4	1	3	2	4	1	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:33272155C>G	uc001bvy.1	-	4	1226	c.438G>C	c.(436-438)AAG>AAC	p.K146N		NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	146					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	CTCCAGCCTTCTTGGAATCGT	0.547													40	93					0	0	0	0	G	33272155	G	G	33272155	3	3	303	1	0	0	0	0	1	0	0	0	17535	912	32	2	1188	2	YARS	1	33272155	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	611536	33272155	215978466	20	55547											
CSMD2	114784	broad.mit.edu	37	chr1	34008457	34008457	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggccatcactgaacacaactCgggcattacttggagtccca	11	8	9	13	1	1	1	1	1	0	0	3	2	2	2	2	3	3	1	2	3	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:34008457C>T	uc001bxn.1	-	57	8737	c.8708G>A	c.(8707-8709)CGA>CAA	p.R2903Q	CSMD2_uc001bxm.1_Missense_Mutation_p.R3047Q	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2903	Sushi 21.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GAACACAACTCGGGCATTACT	0.517													11	30					0	0	0	0	T	34008457	T	T	34008457	3	4	303	1	0	0	0	0	1	0	0	0	3962	884	31	1	1807	1	CSMD2	1	34008457	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	736302	34008457	215242164	21	55548											
UTP11L	51118	broad.mit.edu	37	chr1	38478530	38478530	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcagcgggaacacagagagcGaagccaggtaggaccataca	15	2	14	10	2	0	1	0	0	0	1	0	5	0	3	2	3	5	2	2	3	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:38478530G>A	uc001ccn.3	+	1	147	c.56G>A	c.(55-57)CGA>CAA	p.R19Q	UTP11L_uc009vvm.2_5'UTR|UTP11L_uc010oil.1_RNA	NM_016037	NP_057121	Q9Y3A2	UTP11_HUMAN	UTP11-like, U3 small nucleolar	19					induction of apoptosis|nerve growth factor receptor signaling pathway|nervous system development|rRNA processing	cytoplasm|extracellular space|nucleolus|small-subunit processome	protein binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CACAGAGAGCGAAGCCAGGTA	0.612													43	74					0	0	0	0	A	38478530	A	A	38478530	3	1	303	1	0	0	0	0	1	0	0	0	17162	1058	37	1	58	1	UTP11L	1	38478530	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4470073	38478530	210772091	22	55549											
C1orf210	149466	broad.mit.edu	37	chr1	43748554	43748554	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccatcatcatcctcatcttCagccacctgtgggcggcctc	6	10	8	17	1	5	0	4	0	1	0	7	0	6	0	5	2	1	0	5	2	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:43748554C>T	uc001cit.3	-	3	478	c.244G>A	c.(244-246)GAA>AAA	p.E82K		NM_182517	NP_872323	Q8IVY1	CA210_HUMAN	hypothetical protein LOC149466	82	Cytoplasmic (Potential).					integral to membrane					0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TCCTCATCTTCAGCCACCTGT	0.607													21	60					0	0	0	0	T	43748554	T	T	43748554	3	4	303	1	0	0	0	0	1	0	0	0	2039	835	29	2	101	2	C1orf210	1	43748554	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5270024	43748554	205502067	23	55550											
KIAA0467	23334	broad.mit.edu	37	chr1	43895744	43895744	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttccaatccccactacttCttctattgccctccatccag	7	13	2	19	0	2	0	0	0	2	0	6	0	6	0	7	0	2	0	7	0	3	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:43895744C>T	uc001cjk.1	+	15	2136	c.1674C>T	c.(1672-1674)TTC>TTT	p.F558F		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1457						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCCACTACTTCTTCTATTGCC	0.532													20	64					0	0	0	0	T	43895744	T	T	43895744	2	4	303	1	0	0	0	0	0	0	0	1	8217	912	32	2		2	KIAA0467	1	43895744	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	147190	43895744	205354877	24	55551											
PTPRF	5792	broad.mit.edu	37	chr1	44056897	44056897	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgggcgagggccgcccagcGaggcagtgcgggcacgcacg	6	2	19	14	7	0	0	0	0	0	0	1	2	0	0	2	4	2	3	2	4	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:44056897G>A	uc001cjr.2	+	9	1544	c.1204G>A	c.(1204-1206)GAG>AAG	p.E402K	PTPRF_uc001cjs.2_Missense_Mutation_p.E402K|PTPRF_uc001cju.2_5'UTR|PTPRF_uc009vwt.2_5'UTR|PTPRF_uc001cjv.2_5'UTR	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	402	Extracellular (Potential).|Fibronectin type-III 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCCGCCCAGCGAGGCAGTGCG	0.697													3	10					0	0	0	0	A	44056897	A	A	44056897	3	1	303	1	0	0	0	0	1	0	0	0	12866	1059	37	1	1230	1	PTPRF	1	44056897	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	161153	44056897	205193724	25	55552											
LEPR	3953	broad.mit.edu	37	chr1	66067149	66067149	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttcactgcatctataagaagGaaaacaagattgttccctca	15	11	6	9	0	3	2	2	0	1	2	4	3	4	3	1	1	2	2	1	1	6	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:66067149G>A	uc001dci.2	+	9	1271	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K	LEPR_uc001dcg.2_Missense_Mutation_p.E357K|LEPR_uc001dch.2_Missense_Mutation_p.E357K|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.E357K|LEPR_uc001dck.2_Missense_Mutation_p.E357K	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	357	Extracellular (Potential).|Ig-like.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CTATAAGAAGGAAAACAAGAT	0.358													12	33					0	0	0	0	A	66067149	A	A	66067149	3	1	303	1	0	0	0	0	1	0	0	0	8768	1175	41	2	1095	2	LEPR	1	66067149	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	22010252	66067149	183183472	26	55553											
IL12RB2	3595	broad.mit.edu	37	chr1	67833595	67833595	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcctcccaggaaagatccctCtgctgttcaggagtacgtgg	8	9	12	12	1	2	1	1	0	1	1	4	3	4	3	3	3	2	3	3	3	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:67833595C>G	uc001ddu.2	+	10	1986	c.1346C>G	c.(1345-1347)TCT>TGT	p.S449C	IL12RB2_uc010oqi.1_Missense_Mutation_p.S449C|IL12RB2_uc010oqj.1_Missense_Mutation_p.S449C|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.S449C|IL12RB2_uc010oqm.1_Missense_Mutation_p.S449C|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	449	Fibronectin type-III 4.|Extracellular (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						AAAGATCCCTCTGCTGTTCAG	0.557													33	61					0	0	0	0	G	67833595	G	G	67833595	3	3	303	1	0	0	0	0	1	0	0	0	7666	913	32	2	1380	2	IL12RB2	1	67833595	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1766446	67833595	181417026	27	55554											
TNNI3K	51086	broad.mit.edu	37	chr1	74737282	74737282	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aaagatatgtttccttacagGataatgcagaattgatcact	15	13	7	6	0	1	3	1	1	0	2	2	4	2	4	1	1	2	2	1	1	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:74737282G>A	uc001dgf.1	+	5	385	c.334G>A	c.(334-336)GAT>AAT	p.D112N	TNNI3K_uc001dgc.1_Missense_Mutation_p.D213N|TNNI3K_uc001dgd.2_Missense_Mutation_p.D213N|TNNI3K_uc001dge.1_Missense_Mutation_p.D213N	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	112	ANK 2.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						TTCCTTACAGGATAATGCAGA	0.428													43	145					0	0	0	0	A	74737282	A	A	74737282	3	1	303	1	0	0	0	0	1	0	0	0	16395	1188	41	2	707	2	TNNI3K	1	74737282	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	6903687	74737282	174513339	28	55555											
COL24A1	255631	broad.mit.edu	37	chr1	86591780	86591780	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catttttaaaaatgactcctGattctgttaaatggaccccc	12	14	5	10	0	1	2	0	2	1	0	2	3	2	3	3	1	0	1	3	1	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:86591780G>A	uc001dlj.2	-	3	281	c.239C>T	c.(238-240)TCA>TTA	p.S80L	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.S80L	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	80	TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		AATGACTCCTGATTCTGTTAA	0.438													14	49					0	0	0	0	A	86591780	A	A	86591780	3	1	303	1	0	0	0	0	1	0	0	0	3698	1294	45	2	5137	2	COL24A1	1	86591780	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	11854498	86591780	162658841	29	55556											
GBP1	2633	broad.mit.edu	37	chr1	89523838	89523838	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggtgaacgggccgatcaaaGacaaagcattttttctttgg	11	11	11	8	3	2	2	1	1	1	1	2	3	2	2	1	3	2	1	1	3	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:89523838G>C	uc001dmx.2	-	6	931	c.711C>G	c.(709-711)GTC>GTG	p.V237V		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	237					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		GCCGATCAAAGACAAAGCATT	0.423													44	130					0	0	0	0	C	89523838	C	C	89523838	2	2	303	1	0	0	0	0	0	0	0	1	6308	929	33	2		2	GBP1	1	89523838	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2932058	89523838	159726783	30	55557											
BRDT	676	broad.mit.edu	37	chr1	92469996	92469996	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagattaagaatgcagattCatggaaaagtttaggcaaac	19	9	9	4	0	1	3	1	0	0	3	1	4	1	4	0	2	2	3	0	2	7	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:92469996C>T	uc001dok.3	+	17	2763	c.2414C>T	c.(2413-2415)TCA>TTA	p.S805L	BRDT_uc001dol.3_Missense_Mutation_p.S805L|BRDT_uc010osz.1_Missense_Mutation_p.S809L|BRDT_uc009wdf.2_Missense_Mutation_p.S732L|BRDT_uc010ota.1_Missense_Mutation_p.S759L|BRDT_uc010otb.1_Missense_Mutation_p.S759L|BRDT_uc001dom.3_Missense_Mutation_p.S805L	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	805					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		AATGCAGATTCATGGAAAAGT	0.328													17	59					0	0	0	0	T	92469996	T	T	92469996	3	4	303	1	0	0	0	0	1	0	0	0	1513	838	29	2	2476	2	BRDT	1	92469996	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2946158	92469996	156780625	31	55558											
SASS6	163786	broad.mit.edu	37	chr1	100551111	100551111	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctgaattactaaataggttCtggctgagtccgcgtaaagg	11	11	11	8	2	1	2	0	2	1	0	2	2	2	2	2	3	1	3	2	3	7	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:100551111C>T	uc001dsu.2	-	16	1989	c.1848G>A	c.(1846-1848)CAG>CAA	p.Q616Q	SASS6_uc009wdz.2_Silent_p.Q449Q	NM_194292	NP_919268	Q6UVJ0	SAS6_HUMAN	spindle assembly abnormal protein 6	616					centriole replication	centriole				upper_aerodigestive_tract(1)|ovary(1)	2		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		TAAATAGGTTCTGGCTGAGTC	0.333													27	51					0	0	0	0	T	100551111	T	T	100551111	2	4	303	1	0	0	0	0	0	0	0	1	13915	912	32	2		2	SASS6	1	100551111	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	8081115	100551111	148699510	32	55559											
PRMT6	55170	broad.mit.edu	37	chr1	107599827	107599827	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgggctacggactcctgcacGagtccatgctgagctccgtc	6	9	12	14	3	0	1	0	1	0	0	4	3	3	2	3	2	4	4	3	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:107599827G>T	uc010ous.1	+	1	561	c.490G>T	c.(490-492)GAG>TAG	p.E164*		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	164					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity				0		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		ACTCCTGCACGAGTCCATGCT	0.647													15	71					4.14922e-12	4.27584e-12	1	0	T	107599827	T	T	107599827	4	4	303	1	0	0	0	0	0	1	0	0	12602	1059	37	3	492	3	PRMT6	1	107599827	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7048716	107599827	141650794	33	55560											
HBXIP	10542	broad.mit.edu	37	chr1	110950253	110950253	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcgcctccatcccacccaccGaccactccggctcagaaccc	8	5	5	23	3	1	1	1	0	0	1	5	2	4	1	8	1	1	1	8	1	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:110950253G>A	uc001dzr.2	-	1	294	c.236C>T	c.(235-237)TCG>TTG	p.S79L		NM_006402	NP_006393	O43504	HBXIP_HUMAN	hepatitis B virus x-interacting protein	Error:Variant_position_missing_in_O43504_after_alignment					anti-apoptosis|negative regulation of caspase activity|response to virus|viral genome replication	cytosol	protein binding			large_intestine(1)|ovary(1)|pancreas(1)	3		all_cancers(81;4.08e-06)|all_epithelial(167;4.38e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0237)|all cancers(265;0.0675)|Epithelial(280;0.0732)|Colorectal(144;0.102)|LUSC - Lung squamous cell carcinoma(189;0.134)		CCCACCCACCGACCACTCCGG	0.657													14	33					0	0	0	0	A	110950253	A	A	110950253	3	1	303	1	0	0	0	0	1	0	0	0	7027	1059	37	1	301	1	HBXIP	1	110950253	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3350426	110950253	138300368	34	55561											
KCNA2	3737	broad.mit.edu	37	chr1	111146078	111146078	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttctacttttctttaggtCaggggaggatgggatctttg	7	16	12	6	0	4	0	1	0	3	0	4	3	4	3	0	5	1	0	0	5	2	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:111146078C>T	uc001dzu.2	-	2	1823	c.1327G>A	c.(1327-1329)GAC>AAC	p.D443N	KCNA2_uc009wfv.1_Intron|KCNA2_uc009wfw.2_Missense_Mutation_p.D443N	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	443						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		TTCTTTAGGTCAGGGGAGGAT	0.448													25	76					0	0	0	0	T	111146078	T	T	111146078	3	4	303	1	0	0	0	0	1	0	0	0	8042	826	29	2	176	2	KCNA2	1	111146078	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	195825	111146078	138104543	35	55562											
C1orf103	55791	broad.mit.edu	37	chr1	111494617	111494617	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatggcgtaaaaggctgtaGattatcttggaaaatccatt	14	12	10	5	1	1	2	0	0	1	2	2	3	2	3	1	3	0	3	1	3	6	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:111494617G>C	uc001eaa.2	-	2	1145	c.889C>G	c.(889-891)CTA>GTA	p.L297V	C1orf103_uc001dzz.2_Intron|C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		AAAGGCTGTAGATTATCTTGG	0.353													20	52					0	0	0	0	C	111494617	C	C	111494617	3	2	303	1	0	0	0	0	1	0	0	0	1986	933	33	2	1432	2	C1orf103	1	111494617	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	348539	111494617	137756004	36	55563											
VANGL1	81839	broad.mit.edu	37	chr1	116227957	116227957	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttcatccacattcagcgtCtccaggctgaggagcagcag	9	8	10	14	1	3	1	2	1	1	0	5	2	4	2	3	2	3	3	3	2	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:116227957C>T	uc001efv.1	+	7	1394	c.1123C>T	c.(1123-1125)CTC>TTC	p.L375F	VANGL1_uc009wgy.1_Missense_Mutation_p.L373F	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	vang-like 1	375	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane	protein binding			central_nervous_system(1)	1	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CATTCAGCGTCTCCAGGCTGA	0.582													7	30					0	0	0	0	T	116227957	T	T	116227957	3	4	303	1	0	0	0	0	1	0	0	0	17187	913	32	2	1145	2	VANGL1	1	116227957	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4733340	116227957	133022664	37	55564											
TRIM45	80263	broad.mit.edu	37	chr1	117659368	117659368	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcccgggctctgtggaggtCtgaaaaagataaacactcgg	11	8	12	10	2	2	2	0	1	2	1	4	3	3	3	1	4	1	1	1	4	4	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:117659368C>T	uc001egz.2	-	3	1811	c.1223_splice	c.e3-1	p.D408_splice	TRIM45_uc009whe.2_Splice_Site_p.D390_splice|TRIM45_uc001eha.2_Splice_Site_p.D304_splice	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1							cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		CTGTGGAGGTCTGAAAAAGAT	0.483													12	33					0	0	0	0	T	117659368	T	T	117659368	5	4	303	1	0	0	0	0	0	0	1	0	16587	927	32	2	536	2	TRIM45	1	117659368	Splice_Site	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1431411	117659368	131591253	38	55565											
ANKRD35	148741	broad.mit.edu	37	chr1	145562415	145562415	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gcctcccagagcagcggtctCcgagggctgtgggactgcct	5	7	15	14	2	1	1	0	0	1	1	3	3	2	2	4	3	3	2	4	3	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:145562415C>T	uc001eob.1	+	10	2211	c.2103C>T	c.(2101-2103)CTC>CTT	p.L701L	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Silent_p.L544L	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	701										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCAGCGGTCTCCGAGGGCTGT	0.632													20	16					0	0	0	0	T	145562415	T	T	145562415	2	4	303	1	0	0	0	0	0	0	0	1	664	842	30	2		2	ANKRD35	1	145562415	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	27903047	145562415	103688206	39	55566											
PDZK1	5174	broad.mit.edu	37	chr1	145762294	145762294	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ctaaagaaggaatagtggtgGagtcaaaccatgactcgcac	15	7	11	8	1	1	2	1	1	0	1	2	4	1	4	1	3	1	1	1	3	6	2	rs2306523		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:145762294G>C	uc001eon.1	+	9	1568	c.1471G>C	c.(1471-1473)GAG>CAG	p.E491Q	NBPF10_uc001emp.3_Intron|PDZK1_uc001eoo.1_Missense_Mutation_p.E491Q|PDZK1_uc010oza.1_Missense_Mutation_p.E380Q	NM_002614	NP_002605	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	491					carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			AATAGTGGTGGAGTCAAACCA	0.448													21	41					0	0	0	0	C	145762294	C	C	145762294	3	2	303	1	0	0	0	0	1	0	0	0	11761	1175	41	2	1497	2	PDZK1	1	145762294	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	199879	145762294	103488327	40	55567											
CA14	23632	broad.mit.edu	37	chr1	150236243	150236243	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggttggctgtctctgccttCtcctggctgtttatttcatt	2	20	9	10	0	3	0	1	0	2	0	5	0	3	0	2	3	1	4	2	3	1	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:150236243C>T	uc001etx.2	+	10	1222	c.913C>T	c.(913-915)CTC>TTC	p.L305F		NM_012113	NP_036245	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV precursor	305	Helical; (Potential).					integral to membrane	carbonate dehydratase activity|metal ion binding			ovary(1)	1	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCTCTGCCTTCTCCTGGCTGT	0.383													48	143					0	0	0	0	T	150236243	T	T	150236243	3	4	303	1	0	0	0	0	1	0	0	0	2527	913	32	2	951	2	CA14	1	150236243	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4473949	150236243	99014378	41	55568											
SETDB1	9869	broad.mit.edu	37	chr1	150933151	150933151	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacttcaaagaaggatatgaGagtgatgccccctgttcctc	12	10	9	10	0	1	3	1	2	0	2	3	5	2	4	3	1	2	1	3	1	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:150933151G>C	uc001evu.2	+	16	2803	c.2613G>C	c.(2611-2613)GAG>GAC	p.E871D	SETDB1_uc001evv.2_Missense_Mutation_p.E871D|SETDB1_uc009wmg.1_Missense_Mutation_p.E871D	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	871	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AAGGATATGAGAGTGATGCCC	0.488													27	54					0	0	0	0	C	150933151	C	C	150933151	3	2	303	1	0	0	0	0	1	0	0	0	14203	933	33	2	2671	2	SETDB1	1	150933151	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	696908	150933151	98317470	42	55569											
FLG	2312	broad.mit.edu	37	chr1	152277860	152277860	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctgtctcctgattgttcctCattacgtgttgttctgcttg	3	19	9	10	1	3	1	1	1	2	0	5	1	4	1	2	0	2	5	2	0	1	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:152277860C>G	uc001ezu.1	-	3	9538	c.9502G>C	c.(9502-9504)GAG>CAG	p.E3168Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3168	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATTGTTCCTCATTACGTGTT	0.552									Ichthyosis				83	283					0	0	0	0	G	152277860	G	G	152277860	3	3	303	1	0	0	0	0	1	0	0	0	5954	835	29	2	2687	2	FLG	1	152277860	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1344709	152277860	96972761	43	55570											
LCE1F	353137	broad.mit.edu	37	chr1	152748864	152748864	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgagatgtcttgccagcagaGccagcagcagtgccagcccc	9	5	12	15	1	1	2	0	0	1	2	1	3	1	2	5	0	7	3	5	0	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:152748864G>T	uc010pdv.1	+	1	17	c.17G>T	c.(16-18)AGC>ATC	p.S6I		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	6					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCCAGCAGAGCCAGCAGCAG	0.353													20	86					3.10358e-05	3.14659e-05	1	0	T	152748864	T	T	152748864	3	4	303	1	0	0	0	0	1	0	0	0	8704	971	34	4	19	4	LCE1F	1	152748864	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	471004	152748864	96501757	44	55571											
UBAP2L	9898	broad.mit.edu	37	chr1	154223770	154223770	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaaactgaaacagcagaaGaaaaaagcctccttgacttc	18	6	7	10	0	0	5	0	2	0	3	2	5	1	5	2	0	4	1	2	0	6	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:154223770G>A	uc001fep.3	+	13	1634	c.1467G>A	c.(1465-1467)AAG>AAA	p.K489K	UBAP2L_uc009wot.2_Silent_p.K489K|UBAP2L_uc010pek.1_Silent_p.K481K|UBAP2L_uc010pel.1_Silent_p.K499K|UBAP2L_uc010pen.1_Silent_p.K403K	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	489					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AACAGCAGAAGAAAAAAGCCT	0.463													7	37					0	0	0	0	A	154223770	A	A	154223770	2	1	303	1	0	0	0	0	0	0	0	1	16906	933	33	2		2	UBAP2L	1	154223770	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1474906	154223770	95026851	45	55572											
ADAR	103	broad.mit.edu	37	chr1	154561029	154561029	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacaggaactgtacagacctGatatacagatggaatgacac	17	7	9	8	0	0	4	0	2	0	2	0	6	0	6	1	2	4	1	1	2	6	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:154561029G>A	uc001ffh.2	-	10	3083	c.2883C>T	c.(2881-2883)ATC>ATT	p.I961I	ADAR_uc001ffj.2_Silent_p.I916I|ADAR_uc001ffi.2_Silent_p.I935I|ADAR_uc001ffk.2_Silent_p.I666I	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	961	A to I editase.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GTACAGACCTGATATACAGAT	0.453													30	75					0	0	0	0	A	154561029	A	A	154561029	2	1	303	1	0	0	0	0	0	0	0	1	281	1280	45	2		2	ADAR	1	154561029	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	337259	154561029	94689592	46	55573											
KRTCAP2	200185	broad.mit.edu	37	chr1	155145307	155145307	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgacggctgtacatctgcatCccagcaaagagcagcaggga	12	6	12	11	1	1	2	0	1	1	1	2	3	2	3	1	2	5	6	1	2	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:155145307C>T	uc001fho.2	-	2	170	c.144G>A	c.(142-144)GGG>GGA	p.G48G	RAG1AP1_uc010pey.1_Intron|KRTCAP2_uc001fhp.1_Silent_p.G48G|TRIM46_uc009wpe.1_5'Flank|TRIM46_uc010pez.1_5'Flank|TRIM46_uc001fhq.2_5'Flank|TRIM46_uc001fhr.2_5'Flank|TRIM46_uc001fhs.1_5'Flank|TRIM46_uc001fht.1_5'Flank|TRIM46_uc010pfa.1_5'Flank|TRIM46_uc001fhu.1_5'Flank|TRIM46_uc009wpg.1_5'Flank|TRIM46_uc009wpf.2_5'Flank|TRIM46_uc001fhv.3_5'Flank|TRIM46_uc001fhw.1_5'Flank	NM_173852	NP_776251	Q8N6L1	KTAP2_HUMAN	keratinocyte associated protein 2	48						integral to membrane					0	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.18e-10)|all cancers(21;8.39e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			ACATCTGCATCCCAGCAAAGA	0.637													20	59					0	0	0	0	T	155145307	T	T	155145307	2	4	303	1	0	0	0	0	0	0	0	1	8618	842	30	2		2	KRTCAP2	1	155145307	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	584278	155145307	94105314	47	55574											
OR10J1	26476	broad.mit.edu	37	chr1	159410406	159410406	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	catgaccagctgatctcggtGacctacactgtcatcactcc	9	10	7	15	1	3	3	2	3	1	0	5	3	4	3	3	1	2	1	3	1	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:159410406G>A	uc010piv.1	+	1	858	c.858G>A	c.(856-858)GTG>GTA	p.V286V	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	286	Helical; Name=7; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					TGATCTCGGTGACCTACACTG	0.512													27	96					0	0	0	0	A	159410406	A	A	159410406	2	1	303	1	0	0	0	0	0	0	0	1	10964	1277	45	2		2	OR10J1	1	159410406	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4265099	159410406	89840215	48	55575											
ATP1A2	477	broad.mit.edu	37	chr1	160093059	160093059	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgagatgggcccaacgccctCacaccacctcccacaacccc	10	3	6	22	2	1	1	1	0	0	1	2	2	2	1	7	1	2	0	7	1	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:160093059C>G	uc001fvc.2	+	4	366	c.234C>G	c.(232-234)CTC>CTG	p.L78L	ATP1A2_uc001fvb.2_Silent_p.L78L|ATP1A2_uc010piz.1_5'Flank	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	78	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CCAACGCCCTCACACCACCTC	0.632													72	129					0	0	0	0	G	160093059	G	G	160093059	2	3	303	1	0	0	0	0	0	0	0	1	1131	813	29	2		2	ATP1A2	1	160093059	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	682653	160093059	89157562	49	55576											
PEA15	8682	broad.mit.edu	37	chr1	160181451	160181451	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcgaaaagagtgaggagatCactactggcagtgcctggtt	12	8	14	7	1	1	3	1	1	0	2	1	5	1	3	1	3	3	2	1	3	3	2	rs146555291	byFrequency	TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:160181451C>T	uc001fvk.2	+	2	307	c.117C>T	c.(115-117)ATC>ATT	p.I39I	uc001fvj.1_5'Flank|PEA15_uc001fvl.2_Silent_p.I60I|PEA15_uc001fvm.2_Intron	NM_003768	NP_003759	Q15121	PEA15_HUMAN	phosphoprotein enriched in astrocytes 15	39	DED.				anti-apoptosis|apoptosis|carbohydrate transport|negative regulation of glucose import	cytoplasm|microtubule associated complex	protein binding				0	all_cancers(52;3.11e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGAGGAGATCACTACTGGCA	0.547													18	88					0	0	0	0	T	160181451	T	T	160181451	2	4	303	1	0	0	0	0	0	0	0	1	11765	816	29	2		2	PEA15	1	160181451	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	88392	160181451	89069170	50	55577											
HSPA6	3310	broad.mit.edu	37	chr1	161496277	161496277	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aatctgtcgccccatcttctCcaggctctatggggggcctg	5	11	11	14	1	4	0	0	0	4	0	6	0	4	0	4	4	0	1	4	4	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:161496277C>T	uc001gap.2	+	2	2489	c.1829C>T	c.(1828-1830)TCC>TTC	p.S610F	HSPA6_uc001gaq.2_Missense_Mutation_p.S610F	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	610					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CCCATCTTCTCCAGGCTCTAT	0.622													4	6					0	0	0	0	T	161496277	T	T	161496277	3	4	303	1	0	0	0	0	1	0	0	0	7454	855	30	2	1831	2	HSPA6	1	161496277	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1314826	161496277	87754344	51	55578											
FCGR3B	2215	broad.mit.edu	37	chr1	161596169	161596169	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttcctccttgaacacccaccGaggggcctggagcaacagcc	9	6	10	16	1	0	1	0	1	0	0	2	3	2	2	6	3	4	1	6	3	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:161596169G>A	uc009wul.2	-	4	617	c.343C>T	c.(343-345)CGG>TGG	p.R115W		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	115					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AACACCCACCGAGGGGCCTGG	0.557													8	21					0	0	0	0	A	161596169	A	A	161596169	3	1	303	1	0	0	0	0	1	0	0	0	5817	1057	37	1	366	1	FCGR3B	1	161596169	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	99892	161596169	87654452	52	55579											
DUSP27	92235	broad.mit.edu	37	chr1	167097473	167097473	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acctcaagttcccgagaggaGagcccagagccctacttctt	10	8	9	14	1	2	3	1	0	1	3	3	5	3	3	4	1	3	1	4	1	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:167097473G>A	uc001geb.1	+	5	3105	c.3105G>A	c.(3103-3105)GAG>GAA	p.E1035E		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1035	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CCCGAGAGGAGAGCCCAGAGC	0.592													7	23					0	0	0	0	A	167097473	A	A	167097473	2	1	303	1	0	0	0	0	0	0	0	1	4846	933	33	2		2	DUSP27	1	167097473	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5501304	167097473	82153148	53	55580											
TNN	63923	broad.mit.edu	37	chr1	175049448	175049448	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	agcagatccaagtgcccaagGagcagcacagctatgagatt	14	6	11	10	0	0	2	0	1	0	2	1	4	1	3	2	1	5	4	2	1	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:175049448G>C	uc001gkl.1	+	4	1047	c.934G>C	c.(934-936)GAG>CAG	p.E312Q	TNN_uc010pmx.1_Missense_Mutation_p.E312Q	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	312	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGTGCCCAAGGAGCAGCACAG	0.552													22	49					0	0	0	0	C	175049448	C	C	175049448	3	2	303	1	0	0	0	0	1	0	0	0	16389	1175	41	2	944	2	TNN	1	175049448	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7951975	175049448	74201173	54	55581											
IER5	51278	broad.mit.edu	37	chr1	181058848	181058848	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggaacgtggctaacctcatCagcatcttcggttccagttt	8	12	10	11	2	3	0	2	0	1	0	5	1	4	1	2	3	3	4	2	3	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:181058848C>T	uc001got.3	+	1	1211	c.810C>T	c.(808-810)ATC>ATT	p.I270I		NM_016545	NP_057629	Q5VY09	IER5_HUMAN	immediate early response 5	270										pancreas(1)	1						CTAACCTCATCAGCATCTTCG	0.652													19	21					0	0	0	0	T	181058848	T	T	181058848	2	4	303	1	0	0	0	0	0	0	0	1	7547	816	29	2		2	IER5	1	181058848	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6009400	181058848	68191773	55	55582											
GLT25D2	23127	broad.mit.edu	37	chr1	183907896	183907896	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacactcccagggagccttCatagctcatcccttgaaggc	9	8	8	16	0	2	1	2	1	0	0	4	2	4	2	4	2	2	1	4	2	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:183907896C>T	uc001gqr.2	-	12	2252	c.1880G>A	c.(1879-1881)TGA>TAA	p.*627*	GLT25D2_uc010poj.1_Intron|GLT25D2_uc001gqp.2_Silent_p.*235*|GLT25D2_uc001gqq.2_Silent_p.*364*|GLT25D2_uc001gqs.2_Silent_p.*507*	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	627					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						AGGGAGCCTTCATAGCTCATC	0.507													18	43					0	0	0	0	T	183907896	T	T	183907896	2	4	303	1	0	0	0	0	0	0	0	1	6504	837	29	2		2	GLT25D2	1	183907896	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2849048	183907896	65342725	56	55583											
HMCN1	83872	broad.mit.edu	37	chr1	186056718	186056718	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaatgggcggatgataacaGagtctactcatgtggagatt	13	10	13	5	1	2	4	1	1	1	3	2	6	2	5	0	3	2	0	0	3	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:186056718G>A	uc001grq.1	+	60	9533	c.9304G>A	c.(9304-9306)GAG>AAG	p.E3102K		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3102	Ig-like C2-type 29.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GATGATAACAGAGTCTACTCA	0.428													48	153					0	0	0	0	A	186056718	A	A	186056718	3	1	303	1	0	0	0	0	1	0	0	0	7259	943	33	2	9542	2	HMCN1	1	186056718	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2148822	186056718	63193903	57	55584											
HMCN1	83872	broad.mit.edu	37	chr1	186089237	186089237	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgtgtgtggcccagaacccGgctggtacagccttgggcaa	8	8	14	11	1	0	1	0	0	0	1	0	1	0	1	3	4	3	3	3	4	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:186089237G>A	uc001grq.1	+	80	12418	c.12189G>A	c.(12187-12189)CCG>CCA	p.P4063P		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4063	Ig-like C2-type 39.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CCCAGAACCCGGCTGGTACAG	0.448													16	19					0	0	0	0	A	186089237	A	A	186089237	2	1	303	1	0	0	0	0	0	0	0	1	7259	1103	39	1		1	HMCN1	1	186089237	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	32519	186089237	63161384	58	55585											
B3GALT2	8707	broad.mit.edu	37	chr1	193150607	193150607	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaaacactagagaaagtactCcaataagatgagtgcggaac	18	6	10	7	1	0	3	0	1	0	2	1	6	1	4	1	1	4	1	1	1	7	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:193150607C>G	uc001gtc.3	-	2	801	c.86G>C	c.(85-87)GGA>GCA	p.G29A	CDC73_uc001gtb.2_Intron	NM_003783	NP_003774	O43825	B3GT2_HUMAN	UDP-Gal:betaGlcNAc beta	29	Helical; Signal-anchor for type II membrane protein; (Potential).				protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1						AGAAAGTACTCCAATAAGATG	0.423													14	55					0	0	0	0	G	193150607	G	G	193150607	3	3	303	1	0	0	0	0	1	0	0	0	1250	855	30	2	1186	2	B3GALT2	1	193150607	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	7061370	193150607	56100014	59	55586											
PHLDA3	23612	broad.mit.edu	37	chr1	201437683	201437683	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtcgatctcgccgcccccttCggtcaccagcgtgaagtaga	7	8	11	15	5	2	2	1	1	1	1	5	3	2	2	4	1	1	1	4	1	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:201437683C>T	uc001gwq.2	-	1	617	c.232G>A	c.(232-234)GAA>AAA	p.E78K	PHLDA3_uc009wzx.2_5'UTR	NM_012396	NP_036528	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A,	78	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding				0						CCGCCCCCTTCGGTCACCAGC	0.667													26	111					0	0	0	0	T	201437683	T	T	201437683	3	4	303	1	0	0	0	0	1	0	0	0	11905	893	31	1	155	1	PHLDA3	1	201437683	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	8287076	201437683	47812938	60	55587											
MOSC2	54996	broad.mit.edu	37	chr1	220936311	220936311	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgcctccctggtagatttGaataccaggatggagaagaa	13	9	12	7	0	0	4	0	1	0	3	1	7	1	5	3	3	2	1	3	3	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:220936311G>A	uc001hmq.2	+	4	867	c.669G>A	c.(667-669)TTG>TTA	p.L223L	MOSC2_uc001hmr.2_Silent_p.L223L|MOSC2_uc009xdx.2_Silent_p.L223L	NM_017898	NP_060368	Q969Z3	MOSC2_HUMAN	MOCO sulphurase C-terminal domain containing 2	223	MOSC.					mitochondrial outer membrane|peroxisome	molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding				0				GBM - Glioblastoma multiforme(131;0.00499)|all cancers(67;0.204)		TGGTAGATTTGAATACCAGGA	0.502													41	38					0	0	0	0	A	220936311	A	A	220936311	2	1	303	1	0	0	0	0	0	0	0	1	9767	1281	45	2		2	MOSC2	1	220936311	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	19498628	220936311	28314310	61	55588											
NUP133	55746	broad.mit.edu	37	chr1	229580736	229580736	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aattggatcatctttgccatCagaactggaccagctagaaa	14	10	8	9	0	3	2	2	0	1	2	3	4	3	4	2	2	3	1	2	2	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:229580736C>T	uc001htn.2	-	25	3351	c.3259G>A	c.(3259-3261)GAT>AAT	p.D1087N		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	1087					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				TCTTTGCCATCAGAACTGGAC	0.308													21	76					0	0	0	0	T	229580736	T	T	229580736	3	4	303	1	0	0	0	0	1	0	0	0	10808	826	29	2	219	2	NUP133	1	229580736	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	8644425	229580736	19669885	62	55589											
PGBD5	79605	broad.mit.edu	37	chr1	230473020	230473020	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctgggcccccaccttccttCaggtggacataaatctttaa	9	12	7	13	0	3	0	1	0	2	0	4	1	4	1	4	3	0	0	4	3	3	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:230473020C>T	uc010pwb.1	-	4	702	c.702G>A	c.(700-702)CTG>CTA	p.L234L	PGBD5_uc001htv.2_Silent_p.L333L	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	234						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		CACCTTCCTTCAGGTGGACAT	0.572													4	6					0	0	0	0	T	230473020	T	T	230473020	2	4	303	1	0	0	0	0	0	0	0	1	11839	813	29	2		2	PGBD5	1	230473020	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	892284	230473020	18777601	63	55590											
PGBD5	79605	broad.mit.edu	37	chr1	230492802	230492802	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcctggctcatgacgagggcGaggctgcggttgctgtagaa	7	8	17	9	3	1	2	1	1	0	1	1	4	1	2	1	4	2	5	1	4	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:230492802G>A	uc010pwb.1	-	2	390	c.390C>T	c.(388-390)CTC>CTT	p.L130L	PGBD5_uc001htv.2_Silent_p.L229L	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	130						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		TGACGAGGGCGAGGCTGCGGT	0.612													22	25					0	0	0	0	A	230492802	A	A	230492802	2	1	303	1	0	0	0	0	0	0	0	1	11839	1045	37	1		1	PGBD5	1	230492802	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	19782	230492802	18757819	64	55591											
EXOC8	149371	broad.mit.edu	37	chr1	231472342	231472342	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagctgtcgaactcgctcctCcactttggcccttagttctt	5	14	8	14	2	1	0	0	0	1	0	5	2	3	0	3	1	2	3	3	1	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:231472342C>G	uc001huq.2	-	1	1237	c.1150G>C	c.(1150-1152)GAG>CAG	p.E384Q		NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	384					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				ACTCGCTCCTCCACTTTGGCC	0.517													39	37					0	0	0	0	G	231472342	G	G	231472342	3	3	303	1	0	0	0	0	1	0	0	0	5335	864	30	2	1031	2	EXOC8	1	231472342	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	979540	231472342	17778279	65	55592											
C1orf57	84284	broad.mit.edu	37	chr1	233091354	233091354	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagtgaggttttaaaatcctCtggtgtgcctgttgatggat	8	15	12	6	0	1	2	0	2	1	0	2	3	2	3	2	3	1	2	2	3	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:233091354C>T	uc001hvj.1	+	2	173	c.86C>T	c.(85-87)TCT>TTT	p.S29F	C1orf57_uc001hvi.2_Missense_Mutation_p.S29F|C1orf57_uc009xft.1_Intron	NM_032324	NP_115700	Q9BSD7	NTPCR_HUMAN	nucleoside-triphosphatase C1orf57	29							ATP binding|nucleoside-triphosphatase activity|nucleotide phosphatase activity|transferase activity				0		all_cancers(173;0.0818)|Prostate(94;0.137)				TTAAAATCCTCTGGTGTGCCT	0.393													15	14					0	0	0	0	T	233091354	T	T	233091354	3	4	303	1	0	0	0	0	1	0	0	0	2059	913	32	2	92	2	C1orf57	1	233091354	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1619012	233091354	16159267	66	55593											
C1orf57	84284	broad.mit.edu	37	chr1	233105696	233105696	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcaaagagtgtgcgtcatCgatgagattgggaagatgga	12	8	17	4	2	1	3	1	1	0	3	2	7	1	5	0	3	1	1	0	3	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:233105696C>T	uc001hvj.1	+	4	423	c.336C>T	c.(334-336)ATC>ATT	p.I112I	C1orf57_uc001hvi.2_Silent_p.I112I|C1orf57_uc009xft.1_Intron	NM_032324	NP_115700	Q9BSD7	NTPCR_HUMAN	nucleoside-triphosphatase C1orf57	112	ATP (Probable).						ATP binding|nucleoside-triphosphatase activity|nucleotide phosphatase activity|transferase activity				0		all_cancers(173;0.0818)|Prostate(94;0.137)				TGTGCGTCATCGATGAGATTG	0.507													38	73					0	0	0	0	T	233105696	T	T	233105696	2	4	303	1	0	0	0	0	0	0	0	1	2059	874	31	1		1	C1orf57	1	233105696	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	14342	233105696	16144925	67	55594											
C1orf57	84284	broad.mit.edu	37	chr1	233105723	233105723	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgggaagatggagctcttCagtcagcttttcattcaagc	10	13	10	8	0	5	1	4	0	1	1	5	3	5	3	0	2	3	2	0	2	2	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:233105723C>T	uc001hvj.1	+	4	450	c.363C>T	c.(361-363)TTC>TTT	p.F121F	C1orf57_uc001hvi.2_Silent_p.F121F|C1orf57_uc009xft.1_Intron	NM_032324	NP_115700	Q9BSD7	NTPCR_HUMAN	nucleoside-triphosphatase C1orf57	121							ATP binding|nucleoside-triphosphatase activity|nucleotide phosphatase activity|transferase activity				0		all_cancers(173;0.0818)|Prostate(94;0.137)				TGGAGCTCTTCAGTCAGCTTT	0.512													42	80					0	0	0	0	T	233105723	T	T	233105723	2	4	303	1	0	0	0	0	0	0	0	1	2059	825	29	2		2	C1orf57	1	233105723	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	27	233105723	16144898	68	55595											
RYR2	6262	broad.mit.edu	37	chr1	237814789	237814789	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttattaaatgaacacgcaaaGatgcctcttaaagtaagtat	17	12	6	6	1	1	2	0	1	1	1	1	2	1	2	1	0	2	3	1	0	9	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:237814789G>A	uc001hyl.1	+	51	7932	c.7812G>A	c.(7810-7812)AAG>AAA	p.K2604K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2604	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AACACGCAAAGATGCCTCTTA	0.323													3	5					0	0	0	0	A	237814789	A	A	237814789	2	1	303	1	0	0	0	0	0	0	0	1	13834	933	33	2		2	RYR2	1	237814789	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4709066	237814789	11435832	69	55596											
AHCTF1	25909	broad.mit.edu	37	chr1	247040556	247040556	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagtaactcctctatattCaacctattgcaatgttgccg	10	15	5	11	1	3	0	2	0	1	0	4	0	4	0	3	0	4	3	3	0	6	8			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:247040556C>T	uc001ibu.1	-	21	2716	c.2709G>A	c.(2707-2709)TTG>TTA	p.L903L	AHCTF1_uc001ibv.1_Silent_p.L912L|AHCTF1_uc009xgs.1_5'UTR|AHCTF1_uc001ibw.1_5'Flank	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	903	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CCTCTATATTCAACCTATTGC	0.358													18	74					0	0	0	0	T	247040556	T	T	247040556	2	4	303	1	0	0	0	0	0	0	0	1	408	825	29	2		2	AHCTF1	1	247040556	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	9225767	247040556	2210065	70	55597											
OR2B11	127623	broad.mit.edu	37	chr1	247614691	247614691	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagccagtatggtgtcattCacagcggtgtcagcacacga	11	8	11	11	2	3	0	3	0	0	0	3	1	3	0	1	2	3	2	1	2	1	2	rs141488287		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:247614691C>T	uc010pyx.1	-	1	594	c.594G>A	c.(592-594)GTG>GTA	p.V198V		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	198	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TGGTGTCATTCACAGCGGTGT	0.572													17	25					0	0	0	0	T	247614691	T	T	247614691	2	4	303	1	0	0	0	0	0	0	0	1	11042	813	29	2		2	OR2B11	1	247614691	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	574135	247614691	1635930	71	55598											
OR2M7	391196	broad.mit.edu	37	chr1	248487312	248487312	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgatgtgtcattgcatgagaGgattagtagggaagggaagt	12	11	16	2	0	1	2	1	2	0	1	1	6	1	5	0	3	1	2	0	3	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr1:248487312G>A	uc010pzk.1	-	1	559	c.559C>T	c.(559-561)CTC>TTC	p.L187F		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGCATGAGAGGATTAGTAGG	0.423													52	148					0	0	0	0	A	248487312	A	A	248487312	3	1	303	1	0	0	0	0	1	0	0	0	11068	1000	35	4	382	4	OR2M7	1	248487312	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	872621	248487312	763309	72	55599											
KIDINS220	57498	broad.mit.edu	37	chr2	8919884	8919884	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccagccttgtctgattctGagtgaagctgtcaatggttt	8	14	10	9	0	3	3	1	3	2	0	3	3	3	3	2	1	2	2	2	1	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:8919884G>C	uc002qzc.2	-	18	2472	c.2290C>G	c.(2290-2292)CAG>GAG	p.Q764E	KIDINS220_uc010yiv.1_Missense_Mutation_p.Q530E|KIDINS220_uc002qzd.2_Missense_Mutation_p.Q722E|KIDINS220_uc010yiw.1_Missense_Mutation_p.Q765E	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	764	KAP NTPase.|Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTCTGATTCTGAGTGAAGCTG	0.458													11	27					0	0	0	0	C	8919884	C	C	8919884	3	2	303	1	0	0	0	0	1	0	0	0	8310	1299	45	2	3077	2	KIDINS220	2	8919884	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08		8919884	234279489	73	55600											
NBAS	51594	broad.mit.edu	37	chr2	15470866	15470866	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcaataggtcagctgaattGctacctggaacacctacttc	11	10	8	12	1	1	1	1	1	0	0	2	2	1	2	2	2	5	3	2	2	6	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:15470866G>A	uc002rcc.1	-	36	4229	c.4203C>T	c.(4201-4203)AGC>AGT	p.S1401S	NBAS_uc010exl.1_Silent_p.S473S|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1401										ovary(2)|liver(1)|skin(1)	4						CAGCTGAATTGCTACCTGGAA	0.463													18	38					0	0	0	0	A	15470866	A	A	15470866	2	1	303	1	0	0	0	0	0	0	0	1	10239	1310	46	4		4	NBAS	2	15470866	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	6550982	15470866	227728507	74	55601											
C2orf43	60526	broad.mit.edu	37	chr2	21001118	21001118	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttttgacactttgatcatGaaagaggtctgtccagggcc	9	12	10	10	0	2	4	1	3	1	1	3	4	3	4	3	2	0	0	3	2	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:21001118G>C	uc002rec.2	-	2	139	c.106C>G	c.(106-108)CAT>GAT	p.H36D	C2orf43_uc002rea.1_Missense_Mutation_p.H36D|C2orf43_uc002reb.1_Intron|C2orf43_uc010yka.1_Missense_Mutation_p.H36D|C2orf43_uc010ykb.1_Intron|C2orf43_uc010ykc.1_Missense_Mutation_p.H36D|C2orf43_uc010ykd.1_Missense_Mutation_p.H36D|C2orf43_uc010yke.1_Missense_Mutation_p.H36D|C2orf43_uc010ykf.1_Intron	NM_021925	NP_068744	Q9H6V9	CB043_HUMAN	hypothetical protein LOC60526	36											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTTGATCATGAAAGAGGTCT	0.428													17	45					0	0	0	0	C	21001118	C	C	21001118	3	2	303	1	0	0	0	0	1	0	0	0	2177	1290	45	2	895	2	C2orf43	2	21001118	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5530252	21001118	222198255	75	55602											
APOB	338	broad.mit.edu	37	chr2	21232479	21232479	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taatttctttatcaacatgtCaaggaatttgttaacatctt	13	18	4	6	0	4	0	2	0	2	0	4	1	4	1	0	1	2	1	0	1	6	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:21232479C>G	uc002red.2	-	26	7389	c.7261G>C	c.(7261-7263)GAC>CAC	p.D2421H		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2421					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATCAACATGTCAAGGAATTTG	0.313													15	17					0	0	0	0	G	21232479	G	G	21232479	3	3	303	1	0	0	0	0	1	0	0	0	785	826	29	2	6446	2	APOB	2	21232479	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	231361	21232479	221966894	76	55603											
IFT172	26160	broad.mit.edu	37	chr2	27680779	27680779	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taccaggcggatcatgtcatCatacaacttgtgctttttgt	9	15	8	9	1	3	0	3	0	0	0	3	1	3	1	1	2	4	1	1	2	3	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:27680779C>G	uc002rku.2	-	28	3091	c.3040G>C	c.(3040-3042)GAT>CAT	p.D1014H		NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1014					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					ATCATGTCATCATACAACTTG	0.512													25	50					0	0	0	0	G	27680779	G	G	27680779	3	3	303	1	0	0	0	0	1	0	0	0	7596	826	29	2	2293	2	IFT172	2	27680779	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6448300	27680779	215518594	77	55604											
CLIP4	79745	broad.mit.edu	37	chr2	29366599	29366599	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaaggacagatccctgctGatgttgttccagacccagta	12	9	9	11	0	0	3	0	1	0	2	2	4	2	4	3	1	1	4	3	1	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:29366599G>A	uc002rmv.2	+	7	912	c.673G>A	c.(673-675)GAT>AAT	p.D225N	CLIP4_uc002rmu.2_Missense_Mutation_p.D225N|CLIP4_uc010ezm.1_Missense_Mutation_p.D225N|CLIP4_uc002rmw.2_RNA|CLIP4_uc010ymn.1_Missense_Mutation_p.D207N	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	225										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GATCCCTGCTGATGTTGTTCC	0.423													17	62					0	0	0	0	A	29366599	A	A	29366599	3	1	303	1	0	0	0	0	1	0	0	0	3550	1290	45	2	695	2	CLIP4	2	29366599	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1685820	29366599	213832774	78	55605											
DHX57	90957	broad.mit.edu	37	chr2	39070334	39070334	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	atggaccgcatatatgggctCccatcctgtaatacatacct	11	11	7	12	1	0	0	0	0	0	0	2	1	2	1	4	2	2	3	4	2	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:39070334C>G	uc002rrf.2	-	12	2337	c.2238G>C	c.(2236-2238)GGG>GGC	p.G746G	DHX57_uc002rrd.3_Silent_p.G130G|DHX57_uc002rre.2_Silent_p.G179G	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	746							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				TATATGGGCTCCCATCCTGTA	0.448													6	14					0	0	0	0	G	39070334	G	G	39070334	2	3	303	1	0	0	0	0	0	0	0	1	4535	842	30	2		2	DHX57	2	39070334	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	9703735	39070334	204129039	79	55606											
COX7A2L	9167	broad.mit.edu	37	chr2	42580375	42580375	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	gaaaaacttttgtagctctgGaactttgtttttcccagcat	10	16	7	8	0	1	0	0	0	1	0	2	2	2	1	1	1	4	4	1	1	4	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:42580375G>C	uc002rsk.2	-	2	236	c.181C>G	c.(181-183)CCA>GCA	p.P61A	COX7A2L_uc002rsl.2_RNA	NM_004718	NP_004709	O14548	COX7R_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 2	61					respiratory electron transport chain	mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0						TGTAGCTCTGGAACTTTGTTT	0.393													6	30					0	0	0	0	C	42580375	C	C	42580375	3	2	303	1	0	0	0	0	1	0	0	0	3796	1174	41	2	171	2	COX7A2L	2	42580375	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3510041	42580375	200618998	80	55607											
PREPL	9581	broad.mit.edu	37	chr2	44586819	44586819	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtgaggaatactatacttCaaagcttggagaaataattt	16	12	9	4	0	1	2	1	1	0	1	1	4	1	3	0	3	3	1	0	3	7	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:44586819C>T	uc002ruf.2	-	1	71	c.36G>A	c.(34-36)TTG>TTA	p.L12L	PREPL_uc002rug.2_Silent_p.L12L|PREPL_uc002ruh.2_Silent_p.L12L|PREPL_uc010fax.2_Silent_p.L12L|PREPL_uc002rui.3_Intron|PREPL_uc002ruj.1_Intron|PREPL_uc002ruk.1_Silent_p.L12L|C2orf34_uc002rum.2_5'Flank|C2orf34_uc002rul.2_5'Flank	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	12					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TACTATACTTCAAAGCTTGGA	0.358													19	43					0	0	0	0	T	44586819	T	T	44586819	2	4	303	1	0	0	0	0	0	0	0	1	12537	825	29	2		2	PREPL	2	44586819	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2006444	44586819	198612554	81	55608											
EPCAM	4072	broad.mit.edu	37	chr2	47600696	47600696	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttggtgcacaaaatactgtCatttgctcaaagcgtgagta	12	12	10	7	1	2	1	2	1	0	0	2	1	2	1	0	1	4	4	0	1	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:47600696C>T	uc002rvx.2	+	2	529	c.171C>T	c.(169-171)GTC>GTT	p.V57V	EPCAM_uc002rvw.2_Silent_p.V85V	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	57	Extracellular (Potential).				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						AAAATACTGTCATTTGCTCAA	0.348									Lynch_syndrome				9	34					0	0	0	0	T	47600696	T	T	47600696	2	4	303	1	0	0	0	0	0	0	0	1	5186	813	29	2		2	EPCAM	2	47600696	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3013877	47600696	195598677	82	55609											
CCDC88A	55704	broad.mit.edu	37	chr2	55591157	55591158	+	Frame_Shift_Ins	INS	-	T	T																															attctttcaataaattcctcINSttttttctgacactaaaata																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:55591157_55591158insT	uc002ryv.2	-	6	1256_1257	c.414_415insA	c.(412-417)AAAGAGfs	p.K138fs	CCDC88A_uc010yoz.1_Frame_Shift_Ins_p.K138fs|CCDC88A_uc010ypa.1_Frame_Shift_Ins_p.K138fs|CCDC88A_uc010ypb.1_Frame_Shift_Ins_p.K40fs	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	138_139					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						ATAAATTCCTCTTTTTTCTGAC	0.282													---	---	---								T	55591158	T	T	55591157	7	5	303	1	0	1	1	0	0	0	0	0	2876	922	32	0	5308	0	CCDC88A	2	55591157	Frame_Shift_Ins	INS	-	TCGA-HL-7533-01A-11D-2229-08	7990461	55591157	187608216	83	55610											
KIAA1841	84542	broad.mit.edu	37	chr2	61304130	61304130	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttgcccgcgagatcttttGatatcagaaatgaagtactt	12	13	8	8	2	2	4	1	2	1	2	2	5	2	4	1	0	2	1	1	0	4	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:61304130G>C	uc002saw.3	+	6	810	c.507G>C	c.(505-507)TTG>TTC	p.L169F	KIAA1841_uc002sax.3_Missense_Mutation_p.L23F|KIAA1841_uc002say.2_Missense_Mutation_p.L169F|KIAA1841_uc002sav.3_Missense_Mutation_p.L169F	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	169											0			Epithelial(17;0.193)			GAGATCTTTTGATATCAGAAA	0.378													12	51					0	0	0	0	C	61304130	C	C	61304130	3	2	303	1	0	0	0	0	1	0	0	0	8300	1281	45	2	521	2	KIAA1841	2	61304130	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5712973	61304130	181895243	84	55611											
VPS54	51542	broad.mit.edu	37	chr2	64147045	64147045	+	Silent	SNP	C	T	T																															tttttttcaggtaaagcaatCttcccatctgacagagaatc																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:64147045C>T	uc002scq.2	-	15	2299	c.2136G>A	c.(2134-2136)AAG>AAA	p.K712K	VPS54_uc002scp.2_Silent_p.K700K|VPS54_uc002scn.2_5'UTR|VPS54_uc002sco.2_Silent_p.K197K|VPS54_uc010fct.2_Silent_p.K559K	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	712					protein transport|retrograde transport, endosome to Golgi						0						GTAAAGCAATCTTCCCATCTG	0.353													7	24					0	0	0	0	T	64147045	T	T	64147045	2	4	303	1	0	0	0	0	0	0	0	1	17284	912	32	2		2	VPS54	2	64147045	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2842915	64147045	179052328	85	55612	130	2									
VPS54	51542	broad.mit.edu	37	chr2	64147053	64147053	+	Missense_Mutation	SNP	C	T	T																															aggtaaagcaatcttcccatCtgacagagaatcaacaagat																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:64147053C>T	uc002scq.2	-	15	2291	c.2128G>A	c.(2128-2130)GAT>AAT	p.D710N	VPS54_uc002scp.2_Missense_Mutation_p.D698N|VPS54_uc002scn.2_5'UTR|VPS54_uc002sco.2_Missense_Mutation_p.D195N|VPS54_uc010fct.2_Missense_Mutation_p.D557N	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	710					protein transport|retrograde transport, endosome to Golgi						0						ATCTTCCCATCTGACAGAGAA	0.363													8	25					0	0	0	0	T	64147053	T	T	64147053	3	4	303	1	0	0	0	0	1	0	0	0	17284	913	32	2	841	2	VPS54	2	64147053	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	8	64147053	179052320	86	55613	130	2									
SERTAD2	9792	broad.mit.edu	37	chr2	64863474	64863474	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggtagatgtgggacagagctCctcgatctcgtccaaggcag	9	8	14	10	2	1	2	0	0	1	2	5	4	3	3	2	3	1	3	2	3	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:64863474C>T	uc002sde.1	-	2	829	c.532G>A	c.(532-534)GAG>AAG	p.E178K		NM_014755	NP_055570	Q14140	SRTD2_HUMAN	SERTA domain containing 2	178					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus					0						GGACAGAGCTCCTCGATCTCG	0.617													27	38					0	0	0	0	T	64863474	T	T	64863474	3	4	303	1	0	0	0	0	1	0	0	0	14186	864	30	2	416	2	SERTAD2	2	64863474	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	716421	64863474	178335899	87	55614											
DYSF	8291	broad.mit.edu	37	chr2	71894634	71894634	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctacagccccctgcagccaGacatcgagcaggtaggacct	10	6	10	15	1	1	1	0	0	1	1	2	3	1	2	4	2	5	3	4	2	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:71894634G>A	uc002sie.2	+	47	5705	c.5329G>A	c.(5329-5331)GAC>AAC	p.D1777N	DYSF_uc010feg.2_Missense_Mutation_p.D1808N|DYSF_uc010feh.2_Missense_Mutation_p.D1784N|DYSF_uc002sig.3_Missense_Mutation_p.D1763N|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.D1798N|DYSF_uc010fef.2_Missense_Mutation_p.D1815N|DYSF_uc010fei.2_Missense_Mutation_p.D1794N|DYSF_uc010fek.2_Missense_Mutation_p.D1795N|DYSF_uc010fej.2_Missense_Mutation_p.D1785N|DYSF_uc010fel.2_Missense_Mutation_p.D1764N|DYSF_uc010feo.2_Missense_Mutation_p.D1809N|DYSF_uc010fem.2_Missense_Mutation_p.D1799N|DYSF_uc010fen.2_Missense_Mutation_p.D1816N|DYSF_uc002sif.2_Missense_Mutation_p.D1778N|DYSF_uc010yqy.1_Missense_Mutation_p.D658N|DYSF_uc010yqz.1_Missense_Mutation_p.D538N	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1777	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CCTGCAGCCAGACATCGAGCA	0.637													5	23					0	0	0	0	A	71894634	A	A	71894634	3	1	303	1	0	0	0	0	1	0	0	0	4881	942	33	2	5774	2	DYSF	2	71894634	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7031160	71894634	171304739	88	55615											
TET3	200424	broad.mit.edu	37	chr2	74326531	74326531	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgaggagaaccagaatgcAaaggtgggcagcggagccat	14	3	16	8	2	0	2	0	0	0	2	0	5	0	3	2	4	5	2	2	4	3	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:74326531A>C	uc002skb.3	+	8	2991	c.2991A>C	c.(2989-2991)GCA>GCC	p.A997A		NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	997							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						ACCAGAATGCAAAGGTGGGCA	0.637													9	39					0	0	0	0	C	74326531	C	C	74326531	2	2	303	1	0	0	0	0	0	0	0	1	15837	117	5	5		5	TET3	2	74326531	Silent	SNP	A	TCGA-HL-7533-01A-11D-2229-08	2431897	74326531	168872842	89	55616											
WDR54	84058	broad.mit.edu	37	chr2	74649312	74649312	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagcgctccattcccctgcGaggctcggccgccgccctgt	3	7	13	18	5	0	0	0	0	0	0	3	2	2	1	6	3	2	2	6	3	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:74649312G>T	uc002slb.2	+	2	92	c.32G>T	c.(31-33)CGA>CTA	p.R11L		NM_032118	NP_115494	Q9H977	WDR54_HUMAN	WD repeat domain 54	11											0						ATTCCCCTGCGAGGCTCGGCC	0.652													14	54					1.49906e-05	1.52159e-05	1	0	T	74649312	T	T	74649312	3	4	303	1	0	0	0	0	1	0	0	0	17374	1058	37	3	34	3	WDR54	2	74649312	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	322781	74649312	168550061	90	55617											
POLR1A	25885	broad.mit.edu	37	chr2	86276114	86276114	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggcatcctgccattttcctcGgacctcatcatatgatgcgg	7	12	9	13	2	2	1	2	1	0	0	5	2	4	2	4	3	2	1	4	3	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:86276114G>A	uc002sqs.2	-	18	2906	c.2527C>T	c.(2527-2529)CGA>TGA	p.R843*	POLR1A_uc010ytb.1_Nonsense_Mutation_p.R209*	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	843					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						CATTTTCCTCGGACCTCATCA	0.493													14	28					0	0	0	0	A	86276114	A	A	86276114	4	1	303	1	0	0	0	0	0	1	0	0	12264	1124	39	1	2703	1	POLR1A	2	86276114	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	11626802	86276114	156923259	91	55618											
IMMT	10989	broad.mit.edu	37	chr2	86373214	86373214	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaacagcctgttcgattcctCtgagtctggcataggcagta	9	11	11	10	1	2	1	0	1	2	0	4	3	3	1	2	2	2	4	2	2	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:86373214C>T	uc002sqz.3	-	14	2028	c.1640G>A	c.(1639-1641)AGA>AAA	p.R547K	IMMT_uc002sqy.3_Missense_Mutation_p.R288K|IMMT_uc002srb.3_Missense_Mutation_p.R536K|IMMT_uc002sra.3_Missense_Mutation_p.R546K|IMMT_uc010ytd.1_Missense_Mutation_p.R535K|IMMT_uc010yte.1_Missense_Mutation_p.R500K|IMMT_uc002src.1_Missense_Mutation_p.R283K	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	547	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						TTCGATTCCTCTGAGTCTGGC	0.353													5	11					0	0	0	0	T	86373214	T	T	86373214	3	4	303	1	0	0	0	0	1	0	0	0	7757	913	32	2	644	2	IMMT	2	86373214	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	97100	86373214	156826159	92	55619											
CNNM4	26504	broad.mit.edu	37	chr2	97427042	97427042	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtggacgatgccgagaccctCcacaagtccaccagctgcct	9	6	10	16	2	0	1	0	0	0	1	2	4	2	2	6	1	3	1	6	1	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:97427042C>G	uc002swx.2	+	1	404	c.306C>G	c.(304-306)CTC>CTG	p.L102L		NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	102					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|ovary(1)	3						CCGAGACCCTCCACAAGTCCA	0.637													11	28					0	0	0	0	G	97427042	G	G	97427042	2	3	303	1	0	0	0	0	0	0	0	1	3630	842	30	2		2	CNNM4	2	97427042	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	11053828	97427042	145772331	93	55620											
CHST10	9486	broad.mit.edu	37	chr2	101011994	101011994	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctgaatttctgcatcactGaaggaagagagccgaggaag	13	9	12	7	1	3	3	1	2	2	1	3	7	3	5	1	2	2	1	1	2	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:101011994G>A	uc002tam.2	-	6	869	c.510C>T	c.(508-510)TTC>TTT	p.F170F		NM_004854	NP_004845	O43529	CHSTA_HUMAN	HNK-1 sulfotransferase	170	Lumenal (Potential).				carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				ovary(1)	1						CTGCATCACTGAAGGAAGAGA	0.502													10	31					0	0	0	0	A	101011994	A	A	101011994	2	1	303	1	0	0	0	0	0	0	0	1	3413	1281	45	2		2	CHST10	2	101011994	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3584952	101011994	142187379	94	55621											
RNF149	284996	broad.mit.edu	37	chr2	101925032	101925032	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgagccccgacgctggcttCgcgccgccgccacgccatgg	4	4	14	19	8	0	0	0	0	0	0	1	2	0	0	6	2	1	2	6	2	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:101925032C>T	uc002taz.1	-	1	121	c.19G>A	c.(19-21)GAA>AAA	p.E7K	RNF149_uc002tax.1_RNA	NM_173647	NP_775918	Q8NC42	RN149_HUMAN	ring finger protein 149 precursor	7			E -> K (in a breast cancer sample; somatic mutation).			integral to membrane	ligase activity|zinc ion binding	p.E7K(1)		ovary(1)|breast(1)	2						ACGCTGGCTTCGCGCCGCCGC	0.622													4	9					0	0	0	0	T	101925032	T	T	101925032	3	4	303	1	0	0	0	0	1	0	0	0	13515	893	31	1	1211	1	RNF149	2	101925032	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	913038	101925032	141274341	95	55622											
DPP10	57628	broad.mit.edu	37	chr2	116497356	116497356	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgcccactggtggtcaccaGatggagaaagacttgccttc	9	9	11	12	1	1	3	1	0	0	3	3	4	1	3	3	3	1	0	3	3	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:116497356G>A	uc002tla.1	+	9	1196	c.739G>A	c.(739-741)GAT>AAT	p.D247N	DPP10_uc002tlb.1_Missense_Mutation_p.D197N|DPP10_uc002tlc.1_Missense_Mutation_p.D243N|DPP10_uc002tle.2_Missense_Mutation_p.D251N|DPP10_uc002tlf.1_Missense_Mutation_p.D240N	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	247	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						GTGGTCACCAGATGGAGAAAG	0.468													19	61					0	0	0	0	A	116497356	A	A	116497356	3	1	303	1	0	0	0	0	1	0	0	0	4749	942	33	2	944	2	DPP10	2	116497356	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	14572324	116497356	126702017	96	55623											
LRP1B	53353	broad.mit.edu	37	chr2	141607782	141607782	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agatgcatcgaagtctatcaCagtaacgtcatcaatatcag	15	10	7	9	2	5	1	4	0	1	1	6	2	5	1	0	0	2	2	0	0	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:141607782C>T	uc002tvj.1	-	29	5800	c.4828G>A	c.(4828-4830)GTG>ATG	p.V1610M	LRP1B_uc010fnl.1_Missense_Mutation_p.V792M	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1610	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAGTCTATCACAGTAACGTCA	0.373										TSP Lung(27;0.18)			14	53					0	0	0	0	T	141607782	T	T	141607782	3	4	303	1	0	0	0	0	1	0	0	0	9005	478	17	4	9223	4	LRP1B	2	141607782	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	25110426	141607782	101591591	97	55624											
RIF1	55183	broad.mit.edu	37	chr2	152318760	152318760	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatagtttttttcaggtgtGatattcctgccatgtataat	10	19	7	5	0	1	1	1	1	0	0	2	1	2	1	2	1	1	2	2	1	5	9			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:152318760G>C	uc002txm.2	+	28	3362	c.3232G>C	c.(3232-3234)GAT>CAT	p.D1078H	RIF1_uc002txl.2_Missense_Mutation_p.D1078H|RIF1_uc002txn.2_Missense_Mutation_p.D1078H|RIF1_uc002txo.2_Missense_Mutation_p.D1078H|RIF1_uc002txp.2_5'Flank	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1078					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TTTCAGGTGTGATATTCCTGC	0.269													9	22					0	0	0	0	C	152318760	C	C	152318760	3	2	303	1	0	0	0	0	1	0	0	0	13424	1290	45	2	3338	2	RIF1	2	152318760	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10710978	152318760	90880613	98	55625											
LY75	4065	broad.mit.edu	37	chr2	160710889	160710889	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acatttgctattttgtttttGatggcttttagtcccacaaa	9	19	6	7	0	0	1	0	1	0	0	1	1	1	1	1	1	1	3	1	1	3	8			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:160710889G>C	uc002ubc.3	-	18	2646	c.2577C>G	c.(2575-2577)ATC>ATG	p.I859M	LY75_uc002ubb.3_Missense_Mutation_p.I859M|LY75_uc010fos.2_Missense_Mutation_p.I859M	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	859	Extracellular (Potential).|C-type lectin 5.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TTTTGTTTTTGATGGCTTTTA	0.249													10	25					0	0	0	0	C	160710889	C	C	160710889	3	2	303	1	0	0	0	0	1	0	0	0	9150	1280	45	2	2663	2	LY75	2	160710889	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	8392129	160710889	82488484	99	55626											
ITGB6	3694	broad.mit.edu	37	chr2	161025725	161025725	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caagttatttttgcttacctCatataaatgaacttgttctt	11	19	4	7	0	2	1	1	1	1	0	2	1	2	1	1	0	3	3	1	0	7	9			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:161025725C>T	uc002ubh.2	-	7	1031	c.1015G>A	c.(1015-1017)GAG>AAG	p.E339K	ITGB6_uc010fow.1_RNA|ITGB6_uc010fou.2_Missense_Mutation_p.E339K|ITGB6_uc010zcq.1_Missense_Mutation_p.E297K|ITGB6_uc010fov.1_Missense_Mutation_p.E339K	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	339	Extracellular (Potential).|VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						TTGCTTACCTCATATAAATGA	0.338													17	51					0	0	0	0	T	161025725	T	T	161025725	3	4	303	1	0	0	0	0	1	0	0	0	7938	835	29	2	1387	2	ITGB6	2	161025725	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	314836	161025725	82173648	100	55627											
CSRNP3	80034	broad.mit.edu	37	chr2	166535844	166535844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atagccacattccaggaactCcaaatcagatctctgagaac	15	8	6	12	0	2	2	1	1	1	2	5	4	4	3	3	1	3	0	3	1	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:166535844C>T	uc002udf.2	+	7	1715	c.1339C>T	c.(1339-1341)CCA>TCA	p.P447S	CSRNP3_uc002udg.2_Missense_Mutation_p.P447S	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	447					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						TCCAGGAACTCCAAATCAGAT	0.443													22	42					0	0	0	0	T	166535844	T	T	166535844	3	4	303	1	0	0	0	0	1	0	0	0	3982	855	30	2	1353	2	CSRNP3	2	166535844	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5510119	166535844	76663529	101	55628											
LASS6	253782	broad.mit.edu	37	chr2	169571586	169571586	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	catatgtcaacaatatggccCgagtaggaacgctggtcctt	11	10	10	10	2	1	0	1	0	0	0	2	2	2	1	2	3	2	2	2	3	6	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:169571586C>T	uc002ueb.1	+	7	809	c.685C>T	c.(685-687)CGA>TGA	p.R229*	LASS6_uc002uec.1_Nonsense_Mutation_p.R229*	NM_203463	NP_982288	Q6ZMG9	CERS6_HUMAN	longevity assurance homolog 6	229	Cytoplasmic (Potential).|TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			skin(1)	1						CAATATGGCCCGAGTAGGAAC	0.373													25	67					0	0	0	0	T	169571586	T	T	169571586	4	4	303	1	0	0	0	0	0	1	0	0	8683	644	23	1	711	1	LASS6	2	169571586	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3035742	169571586	73627787	102	55629											
G6PC2	57818	broad.mit.edu	37	chr2	169758992	169758992	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaccttactggtgggtccaaGaaactcagatttacccaaat	13	10	8	10	0	1	2	1	0	0	2	2	3	2	2	3	2	3	0	3	2	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:169758992G>C	uc002uem.2	+	2	348	c.256G>C	c.(256-258)GAA>CAA	p.E86Q	G6PC2_uc002uen.2_Missense_Mutation_p.E86Q|G6PC2_uc010fpv.2_Intron	NM_021176	NP_066999	Q9NQR9	G6PC2_HUMAN	islet-specific glucose-6-phosphatase-related	86	Lumenal (Potential).				gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			pancreas(1)	1						GTGGGTCCAAGAAACTCAGAT	0.368													21	28					0	0	0	0	C	169758992	C	C	169758992	3	2	303	1	0	0	0	0	1	0	0	0	6178	943	33	2	262	2	G6PC2	2	169758992	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	187406	169758992	73440381	103	55630											
TTN	7273	broad.mit.edu	37	chr2	179416576	179416576	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtaacttctgaaccaccatCataaactggagcatcccaag	15	8	6	12	0	2	1	1	1	1	0	3	2	3	2	3	1	4	2	3	1	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:179416576C>T	uc010zfg.1	-	284	83571	c.83347G>A	c.(83347-83349)GAT>AAT	p.D27783N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D21478N|TTN_uc010zfi.1_Missense_Mutation_p.D21411N|TTN_uc010zfj.1_Missense_Mutation_p.D21286N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28710							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAACCACCATCATAAACTGGA	0.413													44	72					0	0	0	0	T	179416576	T	T	179416576	3	4	303	1	0	0	0	0	1	0	0	0	16803	826	29	2	17040	2	TTN	2	179416576	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	9657584	179416576	63782797	104	55631											
TTN	7273	broad.mit.edu	37	chr2	179437484	179437484	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtcccgggcccacttcacctCaggtgcaggccttcctttga	5	10	10	16	1	2	1	2	1	0	0	4	1	4	1	5	3	1	1	5	3	0	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:179437484C>T	uc010zfg.1	-	275	65895	c.65671G>A	c.(65671-65673)GAG>AAG	p.E21891K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E15586K|TTN_uc010zfi.1_Missense_Mutation_p.E15519K|TTN_uc010zfj.1_Missense_Mutation_p.E15394K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22818							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTTCACCTCAGGTGCAGGC	0.468													9	40					0	0	0	0	T	179437484	T	T	179437484	3	4	303	1	0	0	0	0	1	0	0	0	16803	835	29	2	34752	2	TTN	2	179437484	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	20908	179437484	63761889	105	55632											
TTN	7273	broad.mit.edu	37	chr2	179466637	179466637	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttcgggtatgtcatgaactCcatcctattagaaaaggaga	13	11	9	8	1	1	3	1	1	0	2	4	4	3	3	2	2	1	1	2	2	6	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:179466637C>G	uc010zfg.1	-	234	47794	c.47570G>C	c.(47569-47571)GGA>GCA	p.G15857A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G9552A|TTN_uc010zfi.1_Missense_Mutation_p.G9485A|TTN_uc010zfj.1_Missense_Mutation_p.G9360A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16784							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCATGAACTCCATCCTATTA	0.313													10	25					0	0	0	0	G	179466637	G	G	179466637	3	3	303	1	0	0	0	0	1	0	0	0	16803	855	30	2	52731	2	TTN	2	179466637	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	29153	179466637	63732736	106	55633											
TTN	7273	broad.mit.edu	37	chr2	179615718	179615718	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggctcattcttatttcagtCtggaaaatttcttcatcaac	10	17	5	9	0	7	0	4	0	3	0	7	1	7	1	0	2	1	1	0	2	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:179615718C>T	uc002unb.2	-	46	11633	c.11409G>A	c.(11407-11409)CAG>CAA	p.Q3803Q	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTATTTCAGTCTGGAAAATTT	0.348													21	61					0	0	0	0	T	179615718	T	T	179615718	2	4	303	1	0	0	0	0	0	0	0	1	16803	912	32	2		2	TTN	2	179615718	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	149081	179615718	63583655	107	55634											
ZNF385B	151126	broad.mit.edu	37	chr2	180634461	180634461	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ccccttttcttcaaagccccGtagaaaatttgccatattca	11	13	4	13	1	3	1	2	0	1	1	3	1	3	1	5	0	2	1	5	0	5	7	rs146268620		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:180634461G>A	uc002unn.3	-	3	626	c.22C>T	c.(22-24)CGG>TGG	p.R8W		NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	8						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TCAAAGCCCCGTAGAAAATTT	0.413													11	30					0	0	0	0	A	180634461	A	A	180634461	3	1	303	1	0	0	0	0	1	0	0	0	17944	1144	40	1	1454	1	ZNF385B	2	180634461	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1018743	180634461	62564912	108	55635											
COL3A1	1281	broad.mit.edu	37	chr2	189870942	189870942	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	ttttaatcagggaaaccctgGatcagatggtcttccaggcc	10	11	10	10	0	3	1	2	0	1	1	4	3	4	3	3	4	1	0	3	4	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:189870942G>C	uc002uqj.1	+	42	3167	c.3050G>C	c.(3049-3051)GGA>GCA	p.G1017A		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1017	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGAAACCCTGGATCAGATGGT	0.313													12	26					0	0	0	0	C	189870942	C	C	189870942	3	2	303	1	0	0	0	0	1	0	0	0	3703	1174	41	2	3216	2	COL3A1	2	189870942	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	9236481	189870942	53328431	109	55636											
OSGEPL1	64172	broad.mit.edu	37	chr2	190618673	190618673	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tattttgaggtaacaagtctCtctgcttacaaaacagaata	15	13	6	7	0	2	2	0	1	2	1	3	2	2	2	0	1	4	2	0	1	8	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:190618673C>G	uc002uqz.1	-	5	1466	c.932G>C	c.(931-933)AGA>ACA	p.R311T	OSGEPL1_uc002ura.1_RNA	NM_022353	NP_071748	Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	311					proteolysis|tRNA processing		metalloendopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			TAACAAGTCTCTCTGCTTACA	0.378													7	14					0	0	0	0	G	190618673	G	G	190618673	3	3	303	1	0	0	0	0	1	0	0	0	11342	913	32	2	328	2	OSGEPL1	2	190618673	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	747731	190618673	52580700	110	55637											
OSGEPL1	64172	broad.mit.edu	37	chr2	190618706	190618706	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagaatagcccgatgtgttCttttcacaagatgacatgcc	12	11	8	10	1	2	3	1	1	1	2	2	4	2	3	2	0	2	1	2	0	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:190618706C>G	uc002uqz.1	-	5	1433	c.899G>C	c.(898-900)AGA>ACA	p.R300T	OSGEPL1_uc002ura.1_RNA	NM_022353	NP_071748	Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	300					proteolysis|tRNA processing		metalloendopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			CCGATGTGTTCTTTTCACAAG	0.403													8	17					0	0	0	0	G	190618706	G	G	190618706	3	3	303	1	0	0	0	0	1	0	0	0	11342	913	32	2	361	2	OSGEPL1	2	190618706	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	33	190618706	52580667	111	55638											
MYO1B	4430	broad.mit.edu	37	chr2	192160862	192160862	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattggaagtgtggttatatCtgttaacccataccggtctt	9	15	9	8	1	2	0	0	0	2	0	2	1	2	1	2	3	2	2	2	3	5	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:192160862C>T	uc010fsg.2	+	3	416	c.161C>T	c.(160-162)TCT>TTT	p.S54F	MYO1B_uc002usq.2_Missense_Mutation_p.S54F|MYO1B_uc002usr.2_Missense_Mutation_p.S54F|MYO1B_uc002uss.1_Missense_Mutation_p.S54F	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	54	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GTGGTTATATCTGTTAACCCA	0.358													8	15					0	0	0	0	T	192160862	T	T	192160862	3	4	303	1	0	0	0	0	1	0	0	0	10122	913	32	2	167	2	MYO1B	2	192160862	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1542156	192160862	51038511	112	55639											
DNAH7	56171	broad.mit.edu	37	chr2	196741391	196741391	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaattagcagaggtttgtaGatttccttatttagttgatt	10	20	8	3	0	0	3	0	1	0	2	1	3	1	3	1	1	1	4	1	1	5	10			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:196741391G>C	uc002utj.3	-	37	6095	c.5994C>G	c.(5992-5994)ATC>ATG	p.I1998M		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1998	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GAGGTTTGTAGATTTCCTTAT	0.294													8	25					0	0	0	0	C	196741391	C	C	196741391	3	2	303	1	0	0	0	0	1	0	0	0	4628	932	33	2	6196	2	DNAH7	2	196741391	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4580529	196741391	46457982	113	55640											
SF3B1	23451	broad.mit.edu	37	chr2	198288627	198288627	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gtcataataacctgtagaatCgaggcccactccttgagctt	11	11	8	11	1	1	2	1	1	0	1	3	3	2	2	3	1	2	2	3	1	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:198288627C>G	uc002uue.2	-	2	148	c.100G>C	c.(100-102)GAT>CAT	p.D34H	SF3B1_uc010fsk.1_RNA|SF3B1_uc002uuf.2_Missense_Mutation_p.D34H|SF3B1_uc002uug.2_Missense_Mutation_p.D34H	NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	34					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CCTGTAGAATCGAGGCCCACT	0.398													16	23					0	0	0	0	G	198288627	G	G	198288627	3	3	303	1	0	0	0	0	1	0	0	0	14214	884	31	3	3934	3	SF3B1	2	198288627	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1547236	198288627	44910746	114	55641											
ALS2	57679	broad.mit.edu	37	chr2	202622442	202622442	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggctgaggtgcttgtggtaGgcgggctgtggagattagga	6	10	21	4	1	0	2	0	1	0	1	0	4	0	3	0	7	1	4	0	7	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:202622442G>A	uc002uyo.2	-	5	1510	c.1154C>T	c.(1153-1155)CCT>CTT	p.P385L	ALS2_uc002uyp.3_Missense_Mutation_p.P385L|ALS2_uc002uyq.2_Missense_Mutation_p.P385L	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	385					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						GCTTGTGGTAGGCGGGCTGTG	0.428													11	39					0	0	0	0	A	202622442	A	A	202622442	3	1	303	1	0	0	0	0	1	0	0	0	550	1000	35	4	3939	4	ALS2	2	202622442	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4333815	202622442	40576931	115	55642											
GPR1	2825	broad.mit.edu	37	chr2	207041356	207041356	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gataaatttcacccaagtcaGaacatggtgcctgatcaaag	15	9	8	9	0	3	2	3	1	0	1	3	3	3	2	2	1	2	0	2	1	5	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:207041356G>C	uc002vbl.3	-	3	1002	c.616C>G	c.(616-618)CTG>GTG	p.L206V	GPR1_uc010fue.2_Missense_Mutation_p.L206V|GPR1_uc010fuf.2_Missense_Mutation_p.L206V	NM_005279	NP_005270	P46091	GPR1_HUMAN	G protein-coupled receptor 1	206	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		ACCCAAGTCAGAACATGGTGC	0.413													17	37					0	0	0	0	C	207041356	C	C	207041356	3	2	303	1	0	0	0	0	1	0	0	0	6659	933	33	2	455	2	GPR1	2	207041356	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4418914	207041356	36158017	116	55643											
TNS1	7145	broad.mit.edu	37	chr2	218699846	218699846	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgggctgctcggggaggttCcctccatctcctcgaaggcc	4	9	14	14	2	1	0	0	0	1	0	6	2	3	1	4	5	1	3	4	5	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:218699846C>T	uc002vgt.2	-	19	3271	c.2873G>A	c.(2872-2874)GGA>GAA	p.G958E	TNS1_uc002vgr.2_Missense_Mutation_p.G958E|TNS1_uc002vgs.2_Missense_Mutation_p.G958E|TNS1_uc010zjv.1_Missense_Mutation_p.G958E	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	958						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CGGGGAGGTTCCCTCCATCTC	0.582													14	34					0	0	0	0	T	218699846	T	T	218699846	3	4	303	1	0	0	0	0	1	0	0	0	16409	855	30	2	2394	2	TNS1	2	218699846	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	11658490	218699846	24499527	117	55644											
SLC11A1	6556	broad.mit.edu	37	chr2	219249962	219249962	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgacaggcaaggacttgggCgaggtctgccatctctacta	9	9	13	10	1	2	1	0	1	2	0	3	3	2	2	1	4	2	1	1	4	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:219249962C>T	uc002vhv.2	+	4	706	c.366C>T	c.(364-366)GGC>GGT	p.G122G	SLC11A1_uc010zkb.1_Silent_p.G122G|SLC11A1_uc010fvp.1_Silent_p.G122G|SLC11A1_uc010fvq.1_Silent_p.G55G|SLC11A1_uc010zkc.1_Silent_p.G55G|SLC11A1_uc002vhu.1_5'UTR|SLC11A1_uc002vhw.2_5'UTR|SLC11A1_uc010fvr.2_5'Flank	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	122	Cytoplasmic (Potential).				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGACTTGGGCGAGGTCTGCC	0.612													36	103					0	0	0	0	T	219249962	T	T	219249962	2	4	303	1	0	0	0	0	0	0	0	1	14445	755	27	1		1	SLC11A1	2	219249962	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	550116	219249962	23949411	118	55645											
COL4A3	1285	broad.mit.edu	37	chr2	228131711	228131711	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtatgctctcattgcaggaGaaccaggcctcctgtgtaca	10	10	10	11	0	1	1	1	0	1	1	3	2	2	1	3	2	4	4	3	2	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:228131711G>A	uc002vom.1	+	23	1573	c.1411G>A	c.(1411-1413)GAA>AAA	p.E471K	COL4A3_uc002von.1_Missense_Mutation_p.E471K|COL4A3_uc002voo.1_Missense_Mutation_p.E471K|COL4A3_uc002vop.1_Missense_Mutation_p.E471K|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	471	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CATTGCAGGAGAACCAGGCCT	0.433													9	12					0	0	0	0	A	228131711	A	A	228131711	3	1	303	1	0	0	0	0	1	0	0	0	3706	943	33	2	1501	2	COL4A3	2	228131711	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	8881749	228131711	15067662	119	55646											
SPHKAP	80309	broad.mit.edu	37	chr2	228884456	228884456	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagcgtttcttgtgtcttCatggtctcctgggtttaggt	4	17	13	7	1	4	1	1	0	3	1	5	2	4	1	1	3	1	2	1	3	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:228884456C>T	uc002vpq.2	-	7	1161	c.1114G>A	c.(1114-1116)GAA>AAA	p.E372K	SPHKAP_uc002vpp.2_Missense_Mutation_p.E372K|SPHKAP_uc010zlx.1_Missense_Mutation_p.E372K	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	372						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTTGTGTCTTCATGGTCTCCT	0.443													19	36					0	0	0	0	T	228884456	T	T	228884456	3	4	303	1	0	0	0	0	1	0	0	0	15114	835	29	2	4012	2	SPHKAP	2	228884456	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	752745	228884456	14314917	120	55647											
MLPH	79083	broad.mit.edu	37	chr2	238427235	238427235	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagacagcgaccagacagatGaggatggagaacctggctca	14	4	14	9	1	1	5	1	1	0	4	1	9	1	6	2	3	2	1	2	3	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr2:238427235G>A	uc002vwt.2	+	5	726	c.499G>A	c.(499-501)GAG>AAG	p.E167K	MLPH_uc002vws.2_Missense_Mutation_p.E167K|MLPH_uc010fyt.1_Missense_Mutation_p.E167K|MLPH_uc002vwu.2_Missense_Mutation_p.E167K|MLPH_uc002vwv.2_Missense_Mutation_p.E167K|MLPH_uc002vww.2_Missense_Mutation_p.E143K|MLPH_uc002vwx.2_Missense_Mutation_p.E51K|MLPH_uc010fyu.2_5'Flank	NM_024101	NP_077006	Q9BV36	MELPH_HUMAN	melanophilin isoform 1	167							metal ion binding			ovary(1)	1		Breast(86;0.000381)|Renal(207;0.000966)|Ovarian(221;0.0695)|all_hematologic(139;0.095)|all_lung(227;0.17)|Melanoma(123;0.203)		Epithelial(121;1.17e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.02e-10)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.15e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000439)|Lung(119;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0316)		CCAGACAGATGAGGATGGAGA	0.567													9	10					0	0	0	0	A	238427235	A	A	238427235	3	1	303	1	0	0	0	0	1	0	0	0	9686	1291	45	2	513	2	MLPH	2	238427235	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	9542779	238427235	4772138	121	55648											
CNTN6	27255	broad.mit.edu	37	chr3	1424826	1424826	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgaaggagaaggatccctGagtactgtgaccattgtcta	13	10	11	7	0	1	4	0	3	1	1	2	6	2	5	2	2	1	1	2	2	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:1424826G>A	uc003boz.2	+	18	2634	c.2367G>A	c.(2365-2367)CTG>CTA	p.L789L	CNTN6_uc011asj.1_Silent_p.L717L|CNTN6_uc003bpa.2_Silent_p.L789L	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	789	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAGGATCCCTGAGTACTGTGA	0.418													12	27					0	0	0	0	A	1424826	A	A	1424826	2	1	303	1	0	0	0	0	0	0	0	1	3660	1277	45	2		2	CNTN6	3	1424826	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08		1424826	196597604	122	55649											
BHLHE40	8553	broad.mit.edu	37	chr3	5022018	5022018	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgccgcaccggctcatcgaGaaaaagagacgtgaccggat	12	6	12	11	5	1	3	1	1	0	2	2	6	1	4	3	2	1	2	3	2	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:5022018G>C	uc003bqf.2	+	3	490	c.183G>C	c.(181-183)GAG>GAC	p.E61D	uc003bqe.1_5'Flank|uc010hce.1_5'Flank|BHLHE40_uc011asw.1_5'UTR	NM_003670	NP_003661	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	61	Basic motif.					Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCTCATCGAGAAAAAGAGAC	0.572											OREG0015367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	27					0	0	0	0	C	5022018	C	C	5022018	3	2	303	1	0	0	0	0	1	0	0	0	1426	933	33	2	193	2	BHLHE40	3	5022018	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3597192	5022018	193000412	123	55650											
IQSEC1	9922	broad.mit.edu	37	chr3	12977636	12977636	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggcgacagctcctcctcatCgatgtacagggtgacatcac	9	8	11	13	2	2	1	2	1	0	0	5	3	4	1	2	2	2	2	2	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:12977636C>T	uc003bxt.2	-	3	931	c.922G>A	c.(922-924)GAT>AAT	p.D308N	IQSEC1_uc003bxu.3_Missense_Mutation_p.D186N|IQSEC1_uc011auw.1_Missense_Mutation_p.D294N	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	308					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						TCCTCCTCATCGATGTACAGG	0.697													32	74					0	0	0	0	T	12977636	T	T	12977636	3	4	303	1	0	0	0	0	1	0	0	0	7856	884	31	1	2562	1	IQSEC1	3	12977636	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	7955618	12977636	185044794	124	55651											
SCN10A	6336	broad.mit.edu	37	chr3	38763895	38763895	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tttgcagcagggacagtggcGaatgcatcctgtggggagag	9	8	17	7	1	0	1	0	0	0	1	1	4	1	2	1	4	3	3	1	4	1	1	rs146965005		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:38763895G>A	uc003ciq.2	-	19	3361	c.3361C>T	c.(3361-3363)CGC>TGC	p.R1121C		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1121					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGACAGTGGCGAATGCATCCT	0.552													31	128					0	0	0	0	A	38763895	A	A	38763895	3	1	303	1	0	0	0	0	1	0	0	0	13977	1058	37	1	2545	1	SCN10A	3	38763895	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	25786259	38763895	159258535	125	55652											
LIMD1	8994	broad.mit.edu	37	chr3	45636827	45636827	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggactgtggttccagggaGagcctggcgacttctgagat	8	9	15	9	1	1	2	0	1	1	2	2	6	2	3	2	4	1	1	2	4	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:45636827G>A	uc003coq.2	+	1	505	c.456G>A	c.(454-456)GAG>GAA	p.E152E		NM_014240	NP_055055	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	152					cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		GTTCCAGGGAGAGCCTGGCGA	0.612													20	64					0	0	0	0	A	45636827	A	A	45636827	2	1	303	1	0	0	0	0	0	0	0	1	8839	933	33	2		2	LIMD1	3	45636827	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	6872932	45636827	152385603	126	55653											
LIMD1	8994	broad.mit.edu	37	chr3	45718438	45718438	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtggtctggagctcaatgatGaagatggccaccgctgttat	9	11	13	8	1	2	3	1	2	1	1	2	4	2	4	2	3	1	3	2	3	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:45718438G>A	uc003coq.2	+	8	1967	c.1918G>A	c.(1918-1920)GAA>AAA	p.E640K		NM_014240	NP_055055	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	640	LIM zinc-binding 3.|Necessary for nuclear localization.				cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		GCTCAATGATGAAGATGGCCA	0.557													43	148					0	0	0	0	A	45718438	A	A	45718438	3	1	303	1	0	0	0	0	1	0	0	0	8839	1291	45	2	1948	2	LIMD1	3	45718438	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	81611	45718438	152303992	127	55654											
CCR3	1232	broad.mit.edu	37	chr3	46307271	46307271	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgagaatgaccatcttctgtCtcgttctccctctgctcgtt	5	16	7	13	2	5	2	0	2	5	1	8	3	5	2	2	0	1	3	2	0	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:46307271C>T	uc003cpg.1	+	4	1165	c.622C>T	c.(622-624)CTC>TTC	p.L208F	CCR3_uc003cpi.1_Missense_Mutation_p.L208F|CCR3_uc003cpj.1_Missense_Mutation_p.L208F|CCR3_uc003cpk.1_Missense_Mutation_p.L229F|CCR3_uc010hjb.1_Missense_Mutation_p.L226F|CCR3_uc003cpl.1_Missense_Mutation_p.L241F	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	208	Helical; Name=5; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CATCTTCTGTCTCGTTCTCCC	0.468													10	43					0	0	0	0	T	46307271	T	T	46307271	3	4	303	1	0	0	0	0	1	0	0	0	2957	913	32	2	691	2	CCR3	3	46307271	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	588833	46307271	151715159	128	55655											
SEMA3F	6405	broad.mit.edu	37	chr3	50211682	50211682	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcgagtgtgggaacttcGtcaggctcatccagccctgg	7	8	15	11	2	2	0	2	0	0	0	4	2	3	1	2	4	2	1	2	4	1	1	rs149131307		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:50211682G>A	uc003cyj.2	+	5	553	c.355G>A	c.(355-357)GTC>ATC	p.V119I	SEMA3F_uc003cyk.2_Missense_Mutation_p.V119I	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	119	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		TGGGAACTTCGTCAGGCTCAT	0.642													18	50					0	0	0	0	A	50211682	A	A	50211682	3	1	303	1	0	0	0	0	1	0	0	0	14094	1145	40	1	369	1	SEMA3F	3	50211682	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3904411	50211682	147810748	129	55656											
MAPKAPK3	7867	broad.mit.edu	37	chr3	50655186	50655186	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aagtgctggagtgcttccatCggcgcactggacagaagtgt	9	9	14	9	2	0	1	0	0	0	1	2	3	1	3	1	3	2	3	1	3	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:50655186C>G	uc003day.1	+	4	786	c.190C>G	c.(190-192)CGG>GGG	p.R64G	MAPKAPK3_uc003daz.1_Missense_Mutation_p.R64G|MAPKAPK3_uc003dba.1_Missense_Mutation_p.R64G|MAPKAPK3_uc010hlr.1_Missense_Mutation_p.R64G	NM_004635	NP_004626	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated	64	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		GTGCTTCCATCGGCGCACTGG	0.602													33	79					0	0	0	0	G	50655186	G	G	50655186	3	3	303	1	0	0	0	0	1	0	0	0	9343	875	31	3	192	3	MAPKAPK3	3	50655186	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	443504	50655186	147367244	130	55657											
C3orf63	23272	broad.mit.edu	37	chr3	56681004	56681004	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttctgggagctgagtataaGaattttttatcatctaatcg	11	17	8	5	1	3	2	1	1	2	1	4	3	3	3	0	1	1	2	0	1	5	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:56681004G>A	uc003did.3	-	14	1862	c.1761C>T	c.(1759-1761)TTC>TTT	p.F587F	C3orf63_uc003dic.3_Silent_p.F191F|C3orf63_uc003die.3_Silent_p.F587F	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	587										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		CTGAGTATAAGAATTTTTTAT	0.308													6	14					0	0	0	0	A	56681004	A	A	56681004	2	1	303	1	0	0	0	0	0	0	0	1	2249	933	33	2		2	C3orf63	3	56681004	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	6025818	56681004	141341426	131	55658											
CADPS	8618	broad.mit.edu	37	chr3	62636530	62636530	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggctttttacctccaatgAgaaagacagcacgacatctg	13	9	9	10	1	1	2	0	1	1	2	2	4	2	2	2	1	2	2	2	1	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:62636530A>G	uc003dll.2	-	5	1555	c.1195T>C	c.(1195-1197)TCA>CCA	p.S399P	CADPS_uc003dlm.2_Missense_Mutation_p.S399P|CADPS_uc003dln.2_Missense_Mutation_p.S399P	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	399					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ACCTCCAATGAGAAAGACAGC	0.488													11	32					0	0	0	0	G	62636530	G	G	62636530	3	3	303	1	0	0	0	0	1	0	0	0	2582	304	11	5	3043	5	CADPS	3	62636530	Missense_Mutation	SNP	A	TCGA-HL-7533-01A-11D-2229-08	5955526	62636530	135385900	132	55659											
SUCLG2	8801	broad.mit.edu	37	chr3	67451196	67451196	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaccttgagttctagctccCggcaggctttggtgatccca	6	11	11	13	1	1	2	0	2	1	0	3	2	3	2	3	3	1	5	3	3	1	4	rs12492080		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:67451196C>T	uc003dna.3	-	10	1170	c.1142G>A	c.(1141-1143)CGG>CAG	p.R381Q	SUCLG2_uc010hob.2_Missense_Mutation_p.R128Q	NM_003848	NP_003839	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming beta subunit	381					succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|skin(1)	2		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	TTCTAGCTCCCGGCAGGCTTT	0.502													24	71					0	0	0	0	T	67451196	T	T	67451196	3	4	303	1	0	0	0	0	1	0	0	0	15431	652	23	1	308	1	SUCLG2	3	67451196	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4814666	67451196	130571234	133	55660											
MITF	4286	broad.mit.edu	37	chr3	70005647	70005647	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acataaatgaccgcattaaaGaactaggtactttgattccc	15	11	6	9	1	0	3	0	2	0	1	1	3	1	3	2	1	2	2	2	1	7	6	rs147682682		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:70005647G>C	uc003dnz.2	+	8	1095	c.979G>C	c.(979-981)GAA>CAA	p.E327Q	MITF_uc011bgb.1_Missense_Mutation_p.E275Q|MITF_uc003doa.2_Missense_Mutation_p.E326Q|MITF_uc003dob.2_Missense_Mutation_p.E311Q|MITF_uc003dod.2_Missense_Mutation_p.E302Q|MITF_uc003doe.2_Missense_Mutation_p.E220Q|MITF_uc003dof.2_Missense_Mutation_p.E226Q	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	333	Helix-loop-helix motif.				melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		CCGCATTAAAGAACTAGGTAC	0.363			A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						11	26					0	0	0	0	C	70005647	C	C	70005647	3	2	303	1	0	0	0	0	1	0	0	0	9649	943	33	2	1248	2	MITF	3	70005647	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2554451	70005647	128016783	134	55661											
ROBO2	6092	broad.mit.edu	37	chr3	77089919	77089919	+	Translation_Start_Site	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gtttcttaaagaatctggatCctttttaatatgtcaaaatg	13	17	6	5	0	3	1	1	0	2	1	4	2	4	2	1	1	0	1	1	1	7	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:77089919C>G	uc003dpy.3	+	1	626	c.-17C>G	c.(-19--15)ATCCT>ATGCT		ROBO2_uc003dpz.2_Translation_Start_Site|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Translation_Start_Site	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2						apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GAATCTGGATCCTTTTTAATA	0.333													22	45					0	0	0	0	G	77089919	G	G	77089919	1	3	303	1	0	0	0	0	0	0	0	0	13579	870	30	2		2	ROBO2	3	77089919	Translation_Start_Site	SNP	C	TCGA-HL-7533-01A-11D-2229-08	7084272	77089919	120932511	135	55662											
CRYBG3	131544	broad.mit.edu	37	chr3	97596632	97596632	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttctaagaattcatatgtGatgccaaatgaacctactac	15	13	5	8	0	2	3	1	2	1	1	2	3	2	3	2	0	4	0	2	0	7	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:97596632G>C	uc003drx.2	+	1	814	c.750G>C	c.(748-750)GTG>GTC	p.V250V		NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						ATTCATATGTGATGCCAAATG	0.443													7	18					0	0	0	0	C	97596632	C	C	97596632	2	2	303	1	0	0	0	0	0	0	0	1	3928	1277	45	2		2	CRYBG3	3	97596632	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	20506713	97596632	100425798	136	55663											
OR5H1	26341	broad.mit.edu	37	chr3	97852279	97852279	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acctgtggagcccatctcttCtctgtctctttatactatgg	6	16	7	12	0	3	0	0	0	3	0	6	1	3	1	2	2	2	0	2	2	3	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:97852279C>G	uc011bgt.1	+	1	738	c.738C>G	c.(736-738)TTC>TTG	p.F246L		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						CCCATCTCTTCTCTGTCTCTT	0.413													19	34					0	0	0	0	G	97852279	G	G	97852279	3	3	303	1	0	0	0	0	1	0	0	0	11213	912	32	2	740	2	OR5H1	3	97852279	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	255647	97852279	100170151	137	55664											
OR5H6	79295	broad.mit.edu	37	chr3	97983603	97983603	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaccaatgaactatgcattCagctattagtcttgtcattt	11	16	6	8	0	3	2	2	2	1	0	3	2	3	2	1	0	3	2	1	0	5	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:97983603C>G	uc003dsi.1	+	1	475	c.475C>G	c.(475-477)CAG>GAG	p.Q159E		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						ACTATGCATTCAGCTATTAGT	0.353													19	56					0	0	0	0	G	97983603	G	G	97983603	3	3	303	1	0	0	0	0	1	0	0	0	11217	827	29	2	477	2	OR5H6	3	97983603	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	131324	97983603	100038827	138	55665											
CEP97	79598	broad.mit.edu	37	chr3	101443560	101443560	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgcggctttgcctcccggaGaaggtaaggcgatccctacc	8	7	12	14	4	0	1	0	0	0	1	2	3	2	1	4	4	2	2	4	4	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:101443560G>C	uc003dvk.1	+	1	67	c.40G>C	c.(40-42)GAA>CAA	p.E14Q	CEP97_uc010hpm.1_Missense_Mutation_p.E14Q|CEP97_uc011bhf.1_Missense_Mutation_p.E14Q|CEP97_uc003dvl.1_5'Flank	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	14						centrosome|nucleus	protein binding			ovary(2)	2						GCCTCCCGGAGAAGGTAAGGC	0.532													13	28					0	0	0	0	C	101443560	C	C	101443560	3	2	303	1	0	0	0	0	1	0	0	0	3278	943	33	2	42	2	CEP97	3	101443560	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3459957	101443560	96578870	139	55666											
MYH15	22989	broad.mit.edu	37	chr3	108112937	108112937	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acactcctgcaccacctcttCagcttctttctgcatccggg	6	12	6	17	1	4	0	1	0	3	0	6	0	6	0	4	1	3	3	4	1	0	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:108112937C>T	uc003dxa.1	-	37	5317	c.5260G>A	c.(5260-5262)GAA>AAA	p.E1754K		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1754	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						ACCACCTCTTCAGCTTCTTTC	0.498													25	96					0	0	0	0	T	108112937	T	T	108112937	3	4	303	1	0	0	0	0	1	0	0	0	10087	835	29	2	604	2	MYH15	3	108112937	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6669377	108112937	89909493	140	55667											
CCDC80	151887	broad.mit.edu	37	chr3	112326071	112326071	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccaacttcctctccaacgcCtaaaagcttcagaatggtta	12	10	5	14	1	2	1	1	0	1	1	4	1	3	1	4	1	3	2	4	1	6	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:112326071C>G	uc003dzf.2	-	7	2676	c.2458G>C	c.(2458-2460)GGC>CGC	p.G820R	CCDC80_uc011bhv.1_Intron|CCDC80_uc003dzg.2_Missense_Mutation_p.G820R|CCDC80_uc003dzh.1_Missense_Mutation_p.G820R	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	820										ovary(2)	2						TCTCCAACGCCTAAAAGCTTC	0.378													27	44					0	0	0	0	G	112326071	G	G	112326071	3	3	303	1	0	0	0	0	1	0	0	0	2867	681	24	4	402	4	CCDC80	3	112326071	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4213134	112326071	85696359	141	55668											
WDR52	55779	broad.mit.edu	37	chr3	113099899	113099899	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tcacagataattagtaaagtActttcaggctaaaaaagaaa	20	10	6	5	0	2	2	2	0	0	2	2	2	2	2	0	1	1	3	0	1	9	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:113099899A>C	uc003eae.1	-	16	1945	c.1899T>G	c.(1897-1899)AGT>AGG	p.S633R		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	633										central_nervous_system(1)	1						TTAGTAAAGTACTTTCAGGCT	0.269													20	14					0	0	0	0	C	113099899	C	C	113099899	3	2	303	1	0	0	0	0	1	0	0	0	17372	388	14	5	3760	5	WDR52	3	113099899	Missense_Mutation	SNP	A	TCGA-HL-7533-01A-11D-2229-08	773828	113099899	84922531	142	55669											
NAA50	80218	broad.mit.edu	37	chr3	113440619	113440619	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taatttgttcagttgtctgtCttttgcacatctgcattctg	6	20	7	8	0	5	0	1	0	4	0	5	0	5	0	0	0	2	4	0	0	1	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:113440619C>T	uc003ean.1	-	5	798	c.498G>A	c.(496-498)AAG>AAA	p.K166K	NAA50_uc010hqm.1_Silent_p.K92K|NAA50_uc011bij.1_Silent_p.K92K	NM_025146	NP_079422	Q9GZZ1	NAA50_HUMAN	N-acetyltransferase 13	166					N-terminal protein amino acid acetylation	cytoplasm	N-acetyltransferase activity|protein binding				0						AGTTGTCTGTCTTTTGCACAT	0.428													41	72					0	0	0	0	T	113440619	T	T	113440619	2	4	303	1	0	0	0	0	0	0	0	1	10179	912	32	2		2	NAA50	3	113440619	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	340720	113440619	84581811	143	55670											
ZDHHC23	254887	broad.mit.edu	37	chr3	113667698	113667698	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgaagaaaaagaaaaccgaaGaacctgaattggagcccctg	18	5	10	8	1	0	5	0	2	0	3	0	7	0	6	4	1	3	0	4	1	8	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:113667698G>A	uc003eau.2	+	2	348	c.49G>A	c.(49-51)GAA>AAA	p.E17K	ZDHHC23_uc003eav.2_Missense_Mutation_p.E11K	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	17						integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						GAAAACCGAAGAACCTGAATT	0.478													14	62					0	0	0	0	A	113667698	A	A	113667698	3	1	303	1	0	0	0	0	1	0	0	0	17681	943	33	2	51	2	ZDHHC23	3	113667698	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	227079	113667698	84354732	144	55671											
LSAMP	4045	broad.mit.edu	37	chr3	115571361	115571361	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	accttgacttgtttgacatcCgccgaggagacctcgttggc	7	11	11	12	3	0	3	0	2	0	1	2	5	1	3	4	2	0	2	4	2	0	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:115571361C>T	uc003ebt.2	-	4	1118	c.618G>A	c.(616-618)GCG>GCA	p.A206A	LSAMP_uc011bis.1_Silent_p.A206A	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	206	Ig-like C2-type 2.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GTTTGACATCCGCCGAGGAGA	0.532													18	66					0	0	0	0	T	115571361	T	T	115571361	2	4	303	1	0	0	0	0	0	0	0	1	9098	639	23	1		1	LSAMP	3	115571361	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1903663	115571361	82451069	145	55672											
CD80	941	broad.mit.edu	37	chr3	119256113	119256113	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagctcagtttcaggatcttGggaaactgttgtgttgatgg	8	14	14	5	0	3	1	2	1	1	0	3	4	3	3	0	3	2	4	0	3	1	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:119256113G>C	uc003ecq.2	-	4	966	c.571C>G	c.(571-573)CAA>GAA	p.Q191E	CD80_uc010hqt.1_Missense_Mutation_p.Q191E|CD80_uc010hqu.1_Intron	NM_005191	NP_005182	P33681	CD80_HUMAN	CD80 antigen precursor	191	Extracellular (Potential).|Ig-like C2-type.				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2					Abatacept(DB01281)	TCAGGATCTTGGGAAACTGTT	0.418													49	84					0	0	0	0	C	119256113	C	C	119256113	3	2	303	1	0	0	0	0	1	0	0	0	3053	1357	47	4	307	4	CD80	3	119256113	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3684752	119256113	78766317	146	55673											
C3orf15	89876	broad.mit.edu	37	chr3	119422063	119422063	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaatcgagcgtatgattttCtgtacggtaaggaccgccgc	9	10	11	11	5	1	1	0	1	1	0	2	3	1	2	3	2	2	3	3	2	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:119422063C>T	uc010hqx.1	+	1	195	c.118C>T	c.(118-120)CTG>TTG	p.L40L	C3orf15_uc003edc.2_Silent_p.L40L|C3orf15_uc010hqy.1_Silent_p.L40L|C3orf15_uc003ede.3_Silent_p.L40L|C3orf15_uc010hqz.2_Silent_p.F3F|C3orf15_uc011bjd.1_5'UTR|C3orf15_uc011bje.1_Silent_p.F3F|C3orf15_uc010hra.1_5'Flank			Q7Z4T9	AAT1_HUMAN	RecName: Full=AMY-1-associating protein expressed in testis 1;          Short=AAT-1;	40						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		GTATGATTTTCTGTACGGTAA	0.652													9	26					0	0	0	0	T	119422063	T	T	119422063	2	4	303	1	0	0	0	0	0	0	0	1	2219	912	32	2		2	C3orf15	3	119422063	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	165950	119422063	78600367	147	55674											
HCLS1	3059	broad.mit.edu	37	chr3	121353058	121353058	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggccaggcgctcacctctGaggagattttcttgggcagt	7	10	14	10	1	3	2	1	1	2	1	3	3	3	2	2	4	0	2	2	4	0	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:121353058G>A	uc003eeh.3	-	10	1024	c.899C>T	c.(898-900)TCA>TTA	p.S300L	HCLS1_uc011bjj.1_Missense_Mutation_p.S263L|HCLS1_uc011bjk.1_RNA	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	300					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		GCTCACCTCTGAGGAGATTTT	0.567													17	92					0	0	0	0	A	121353058	A	A	121353058	3	1	303	1	0	0	0	0	1	0	0	0	7034	1294	45	2	581	2	HCLS1	3	121353058	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1930995	121353058	76669372	148	55675											
PDIA5	10954	broad.mit.edu	37	chr3	122842957	122842957	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcctctgaatttgaaaacatCaaggaggagtacagcgtgcg	13	9	11	8	2	2	2	1	2	1	0	3	4	3	4	1	2	4	1	1	2	5	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:122842957C>G	uc003egc.1	+	9	710	c.654C>G	c.(652-654)ATC>ATG	p.I218M	PDIA5_uc003egd.1_RNA	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	218	Thioredoxin 1.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		TTGAAAACATCAAGGAGGAGT	0.557													36	49					0	0	0	0	G	122842957	G	G	122842957	3	3	303	1	0	0	0	0	1	0	0	0	11725	816	29	2	688	2	PDIA5	3	122842957	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1489899	122842957	75179473	149	55676											
DNAJC13	23317	broad.mit.edu	37	chr3	132222058	132222058	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cttaattttttttataacagGaggtagcaaacagccttgcc	12	14	7	8	0	0	0	0	0	0	0	0	1	0	1	2	2	5	2	2	2	5	8			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:132222058G>A	uc003eor.2	+	41	4782	c.4717G>A	c.(4717-4719)GAG>AAG	p.E1573K		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1573							heat shock protein binding			ovary(1)|breast(1)	2						TTTATAACAGGAGGTAGCAAA	0.363													9	36					0	0	0	0	A	132222058	A	A	132222058	3	1	303	1	0	0	0	0	1	0	0	0	4654	1188	41	2	4875	2	DNAJC13	3	132222058	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	9379101	132222058	65800372	150	55677											
SLCO2A1	6578	broad.mit.edu	37	chr3	133667438	133667438	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcttctccaggaacttgttGaggaaggtggagaggccagc	9	9	15	8	0	1	2	0	1	1	1	2	5	1	4	2	5	3	2	2	5	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:133667438G>C	uc003eqa.3	-	8	1321	c.1047C>G	c.(1045-1047)CTC>CTG	p.L349L	SLCO2A1_uc003eqb.3_Silent_p.L273L|SLCO2A1_uc011blv.1_Silent_p.L168L	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	349	Extracellular (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						GGAACTTGTTGAGGAAGGTGG	0.577													76	165					0	0	0	0	C	133667438	C	C	133667438	2	2	303	1	0	0	0	0	0	0	0	1	14790	1277	45	2		2	SLCO2A1	3	133667438	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1445380	133667438	64354992	151	55678											
PPP2R3A	5523	broad.mit.edu	37	chr3	135720853	135720853	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	tataacaacgatgggaacgcCccatcctttggtttactgcg	10	11	9	11	3	0	0	0	0	0	0	1	2	1	1	3	2	5	1	3	2	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:135720853C>T	uc003eqv.1	+	2	1078	c.513C>T	c.(511-513)GCC>GCT	p.A171A	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	171					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						ATGGGAACGCCCCATCCTTTG	0.423													17	41					0	0	0	0	T	135720853	T	T	135720853	2	4	303	1	0	0	0	0	0	0	0	1	12448	610	22	4		4	PPP2R3A	3	135720853	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2053415	135720853	62301577	152	55679											
PPP2R3A	5523	broad.mit.edu	37	chr3	135745863	135745863	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtagtaatcatgaacaaactCtaagcagaattgaaactgct	17	10	7	7	0	2	3	1	2	1	1	2	3	2	3	0	0	5	4	0	0	7	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:135745863C>G	uc003eqv.1	+	3	2750	c.2185C>G	c.(2185-2187)CTA>GTA	p.L729V	PPP2R3A_uc011blz.1_5'UTR|PPP2R3A_uc003eqw.1_Missense_Mutation_p.L108V|PPP2R3A_uc011bma.1_RNA	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	729					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						TGAACAAACTCTAAGCAGAAT	0.363													15	43					0	0	0	0	G	135745863	G	G	135745863	3	3	303	1	0	0	0	0	1	0	0	0	12448	912	32	2	2327	2	PPP2R3A	3	135745863	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	25010	135745863	62276567	153	55680											
MSL2	55167	broad.mit.edu	37	chr3	135870601	135870601	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaattttgctctcccgtttCactgtcacaggagcagatgc	9	12	9	11	1	3	1	2	0	1	1	4	3	3	2	1	1	3	3	1	1	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:135870601C>T	uc003eqx.1	-	2	1855	c.1122G>A	c.(1120-1122)GTG>GTA	p.V374V	MSL2_uc011bmb.1_Silent_p.V300V	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	374					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						TCTCCCGTTTCACTGTCACAG	0.443													21	51					0	0	0	0	T	135870601	T	T	135870601	2	4	303	1	0	0	0	0	0	0	0	1	9931	813	29	2		2	MSL2	3	135870601	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	124738	135870601	62151829	154	55681											
ZBTB38	253461	broad.mit.edu	37	chr3	141163753	141163753	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccctttgccaaataacagtGaaaattggaaacgaagccat	16	8	7	10	1	0	1	0	1	0	0	0	3	0	2	4	1	4	0	4	1	6	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:141163753G>A	uc003etw.2	+	8	3505	c.2523G>A	c.(2521-2523)GTG>GTA	p.V841V	ZBTB38_uc010hun.2_Silent_p.V838V|ZBTB38_uc010huo.2_Silent_p.V841V|ZBTB38_uc003ety.2_Silent_p.V841V|ZBTB38_uc010hup.2_Silent_p.V842V	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	841					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AAATAACAGTGAAAATTGGAA	0.413													9	43					0	0	0	0	A	141163753	A	A	141163753	2	1	303	1	0	0	0	0	0	0	0	1	17606	1277	45	2		2	ZBTB38	3	141163753	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5293152	141163753	56858677	155	55682											
RASA2	5922	broad.mit.edu	37	chr3	141205979	141205979	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tcttccgaggcgccagcggcGagtgcgactgcagagcccga	7	5	15	14	6	1	1	0	0	1	1	2	5	2	1	3	2	4	1	3	2	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:141205979G>C	uc003etz.1	+	1	54	c.54G>C	c.(52-54)GCG>GCC	p.A18A	RASA2_uc010huq.1_Silent_p.A18A|RASA2_uc003eua.1_Silent_p.A18A	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	18	Ala-rich.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						cgccagcggcgAGTGCGACTG	0.348													2	5					0	0	0	0	C	141205979	C	C	141205979	2	2	303	1	0	0	0	0	0	0	0	1	13126	1045	37	3		3	RASA2	3	141205979	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	42226	141205979	56816451	156	55683											
TRPC1	7220	broad.mit.edu	37	chr3	142467159	142467159	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actatggatgttgcacctgtCattttagctgctcatcgtaa	9	15	8	9	1	2	0	2	0	0	0	3	1	2	1	1	1	3	5	1	1	3	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:142467159C>T	uc003evc.2	+	4	625	c.489C>T	c.(487-489)GTC>GTT	p.V163V	TRPC1_uc003evb.2_Silent_p.V129V	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	163	Cytoplasmic (Potential).|ANK 4.				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						TTGCACCTGTCATTTTAGCTG	0.353													34	124					0	0	0	0	T	142467159	T	T	142467159	2	4	303	1	0	0	0	0	0	0	0	1	16645	813	29	2		2	TRPC1	3	142467159	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1261180	142467159	55555271	157	55684											
HLTF	6596	broad.mit.edu	37	chr3	148757389	148757389	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taagtggtatttctattaaaGacaggaatgttgtaaactga	15	14	9	3	0	1	2	0	1	1	1	1	3	1	3	0	2	1	3	0	2	8	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:148757389G>C	uc003ewq.1	-	22	2812	c.2594C>G	c.(2593-2595)TCT>TGT	p.S865C	HLTF_uc003ewr.1_Missense_Mutation_p.S865C|HLTF_uc003ews.1_Missense_Mutation_p.S864C|HLTF_uc010hve.1_Missense_Mutation_p.S864C	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	865	Helicase C-terminal.				chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TTCTATTAAAGACAGGAATGT	0.299													11	27					0	0	0	0	C	148757389	C	C	148757389	3	2	303	1	0	0	0	0	1	0	0	0	7254	942	33	2	451	2	HLTF	3	148757389	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	6290230	148757389	49265041	158	55685											
SLITRK3	22865	broad.mit.edu	37	chr3	164906079	164906079	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagttcccccaactactcctGaaaccccaccaactgctggg	10	7	6	18	0	0	1	0	1	0	0	2	1	2	1	6	1	5	2	6	1	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:164906079G>A	uc003fej.3	-	2	2984	c.2540C>T	c.(2539-2541)TCA>TTA	p.S847L	SLITRK3_uc003fek.2_Missense_Mutation_p.S847L	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	847	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						AACTACTCCTGAAACCCCACC	0.572										HNSCC(40;0.11)			71	156					0	0	0	0	A	164906079	A	A	164906079	3	1	303	1	0	0	0	0	1	0	0	0	14808	1294	45	2	397	2	SLITRK3	3	164906079	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	16148690	164906079	33116351	159	55686											
NCEH1	57552	broad.mit.edu	37	chr3	172351349	172351349	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgggccagctagtgaaaatCatacatccgtgaaagccatc	13	8	10	10	1	1	2	1	2	0	0	3	2	2	2	3	1	3	1	3	1	5	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:172351349C>G	uc011bpx.1	-	5	1401	c.1263G>C	c.(1261-1263)ATG>ATC	p.M421I	NCEH1_uc003fig.2_Missense_Mutation_p.M413I|NCEH1_uc011bpw.1_Missense_Mutation_p.M248I|NCEH1_uc011bpy.1_Missense_Mutation_p.M248I	NM_001146276	NP_001139748	Q6PIU2	NCEH1_HUMAN	arylacetamide deacetylase-like 1 isoform a	381	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity				0						TAGTGAAAATCATACATCCGT	0.483													23	70					0	0	0	0	G	172351349	G	G	172351349	3	3	303	1	0	0	0	0	1	0	0	0	10269	826	29	2	87	2	NCEH1	3	172351349	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	7445270	172351349	25671081	160	55687											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	13	12	7	9	0	4	4	1	2	3	2	6	5	5	4	1	1	1	1	1	1	3	3	rs104886003		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			19	33					0	0	0	0	A	178936091	A	A	178936091	3	1	303	1	0	0	0	0	1	0	0	0	11968	1291	45	2	1667	2	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	6584742	178936091	19086339	161	55688											
MFN1	55669	broad.mit.edu	37	chr3	179085838	179085838	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttacaggtgtggcacttgctGaaggatttcatgcaagatta	11	13	11	6	0	1	2	1	1	0	1	1	3	1	3	0	3	3	3	0	3	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:179085838G>A	uc003fjs.2	+	9	1048	c.922G>A	c.(922-924)GAA>AAA	p.E308K	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.E336K|MFN1_uc010hxc.2_Missense_Mutation_p.E161K	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	308	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			GGCACTTGCTGAAGGATTTCA	0.323													10	46					0	0	0	0	A	179085838	A	A	179085838	3	1	303	1	0	0	0	0	1	0	0	0	9576	1291	45	2	952	2	MFN1	3	179085838	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	149747	179085838	18936592	162	55689											
PEX5L	51555	broad.mit.edu	37	chr3	179593236	179593236	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	atctccatgaaacttaacatCgtcccatttttccagttgtg	10	15	5	11	1	1	1	0	1	1	0	5	1	3	1	3	0	2	1	3	0	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:179593236C>G	uc003fki.1	-	6	665	c.535G>C	c.(535-537)GAT>CAT	p.D179H	PEX5L_uc011bqd.1_Missense_Mutation_p.D136H|PEX5L_uc011bqe.1_5'UTR|PEX5L_uc011bqf.1_Missense_Mutation_p.D71H|PEX5L_uc003fkj.1_Missense_Mutation_p.D144H|PEX5L_uc010hxd.1_Missense_Mutation_p.D177H|PEX5L_uc011bqg.1_Missense_Mutation_p.D155H|PEX5L_uc011bqh.1_Missense_Mutation_p.D120H	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	179					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			AACTTAACATCGTCCCATTTT	0.498													16	45					0	0	0	0	G	179593236	G	G	179593236	3	3	303	1	0	0	0	0	1	0	0	0	11804	884	31	3	1385	3	PEX5L	3	179593236	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	507398	179593236	18429194	163	55690											
TTC14	151613	broad.mit.edu	37	chr3	180325500	180325500	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaagctttggctttggatGagacttttaaagatgcagag	13	12	12	4	0	0	4	0	1	0	4	0	6	0	5	0	2	2	3	0	2	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:180325500G>A	uc003fkk.2	+	10	1369	c.1237G>A	c.(1237-1239)GAG>AAG	p.E413K	TTC14_uc003fkl.2_Missense_Mutation_p.E413K|TTC14_uc003fkm.2_Missense_Mutation_p.E413K	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	413	TPR 4.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GGCTTTGGATGAGACTTTTAA	0.284													7	35					0	0	0	0	A	180325500	A	A	180325500	3	1	303	1	0	0	0	0	1	0	0	0	16749	1291	45	2	1275	2	TTC14	3	180325500	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	732264	180325500	17696930	164	55691											
PSMD2	5708	broad.mit.edu	37	chr3	184021128	184021128	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtttgggggcagtggctctCaggtggactctgcccgcatg	4	10	17	10	1	2	0	1	0	2	0	3	1	2	1	1	6	1	4	1	6	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:184021128C>G	uc003fnn.1	+	9	1123	c.1090C>G	c.(1090-1092)CAG>GAG	p.Q364E	PSMD2_uc011brj.1_Missense_Mutation_p.Q205E|PSMD2_uc011brk.1_Missense_Mutation_p.Q234E	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	364					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	CAGTGGCTCTCAGGTGGACTC	0.507													23	129					0	0	0	0	G	184021128	G	G	184021128	3	3	303	1	0	0	0	0	1	0	0	0	12760	827	29	2	1124	2	PSMD2	3	184021128	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3695628	184021128	14001302	165	55692											
TP63	8626	broad.mit.edu	37	chr3	189611995	189611995	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caccttcccctgttgcacagGatctggcaagtctgaaaatc	10	10	8	13	0	2	1	0	1	2	0	4	2	3	2	3	2	1	3	3	2	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:189611995G>C	uc003fry.2	+	14	1836	c.1747G>C	c.(1747-1749)GAT>CAT	p.D583H	TP63_uc003frz.2_Missense_Mutation_p.R551S|TP63_uc010hzc.1_Missense_Mutation_p.R503T|TP63_uc003fsc.2_Missense_Mutation_p.D489H|TP63_uc003fsd.2_Missense_Mutation_p.R457S|TP63_uc010hzd.1_Missense_Mutation_p.D404H	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	583	SAM.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TGTTGCACAGGATCTGGCAAG	0.493									Hay-Wells_syndrome	HNSCC(45;0.13)			11	53					0	0	0	0	C	189611995	C	C	189611995	3	2	303	1	0	0	0	0	1	0	0	0	16459	1188	41	2	1966	2	TP63	3	189611995	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5590867	189611995	8410435	166	55693											
C3orf59	151963	broad.mit.edu	37	chr3	192517200	192517200	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtcccctcatcaaagagccGaaggctcagccaagagtggc	11	6	11	13	1	3	2	3	0	0	2	4	3	4	2	4	2	2	1	4	2	3	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:192517200G>A	uc011bsp.1	-	2	772	c.451C>T	c.(451-453)CGG>TGG	p.R151W		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	151											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TCAAAGAGCCGAAGGCTCAGC	0.512													29	37					0	0	0	0	A	192517200	A	A	192517200	3	1	303	1	0	0	0	0	1	0	0	0	2247	1057	37	1	1028	1	C3orf59	3	192517200	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2905205	192517200	5505230	167	55694											
GP5	2814	broad.mit.edu	37	chr3	194118045	194118045	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgcgctcagccgcgggctcaGagtcacccctaagtaccgca	8	5	11	17	5	3	1	3	0	0	1	3	1	3	1	4	1	2	4	4	1	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:194118045G>A	uc003ftv.1	-	2	998	c.967C>T	c.(967-969)CTG>TTG	p.L323L		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	323	Extracellular (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		CGCGGGCTCAGAGTCACCCCT	0.731													5	14					0	0	0	0	A	194118045	A	A	194118045	2	1	303	1	0	0	0	0	0	0	0	1	6621	933	33	2		2	GP5	3	194118045	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1600845	194118045	3904385	168	55695											
FYTTD1	84248	broad.mit.edu	37	chr3	197476886	197476886	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtgggagccacggcgacttCttcgccgccgccgaaggccc	5	5	15	16	6	1	0	0	0	1	0	2	3	1	1	5	4	1	0	5	4	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr3:197476886C>T	uc003fyi.2	+	1	263	c.44C>T	c.(43-45)TCT>TTT	p.S15F	KIAA0226_uc003fyd.3_5'Flank|KIAA0226_uc003fyf.2_5'Flank|FYTTD1_uc011bui.1_Intron|FYTTD1_uc011buj.1_RNA|FYTTD1_uc011buk.1_5'Flank	NM_032288	NP_115664	Q96QD9	UIF_HUMAN	forty-two-three domain containing 1 isoform 1	15					mRNA export from nucleus	nuclear speck	mRNA binding|protein binding				0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.175)		ACGGCGACTTCTTCGCCGCCG	0.652													20	34					0	0	0	0	T	197476886	T	T	197476886	3	4	303	1	0	0	0	0	1	0	0	0	6161	913	32	2	46	2	FYTTD1	3	197476886	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3358841	197476886	545544	169	55696											
HTT	3064	broad.mit.edu	37	chr4	3144492	3144492	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctctatatttttgttattaGaatatatagaggctataacc	13	18	5	5	0	1	2	0	0	1	2	2	2	1	2	1	1	1	2	1	1	10	11			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:3144492G>C	uc011bvq.1	+	24	3097	c.2952_splice	c.e24-1	p.R984_splice		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin						establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TTTGTTATTAGAATATATAGA	0.259													9	19					0	0	0	0	C	3144492	C	C	3144492	5	2	303	1	0	0	0	0	0	0	1	0	7496	956	33	2	3035	2	HTT	4	3144492	Splice_Site	SNP	G	TCGA-HL-7533-01A-11D-2229-08		3144492	188009784	170	55697											
STK32B	55351	broad.mit.edu	37	chr4	5461941	5461941	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcaagaaggcactgatgcccGgctttgtgcccaatgtgagt	9	10	12	10	1	1	3	1	2	0	1	1	3	1	3	2	2	2	2	2	2	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:5461941G>T	uc003gih.1	+	9	959	c.895G>T	c.(895-897)GGC>TGC	p.G299C	STK32B_uc010ida.1_Missense_Mutation_p.G252C	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	299							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						ACTGATGCCCGGCTTTGTGCC	0.587											OREG0016061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	82					4.35082e-09	4.45743e-09	1	0	T	5461941	T	T	5461941	3	4	303	1	0	0	0	0	1	0	0	0	15364	1116	39	3	929	3	STK32B	4	5461941	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2317449	5461941	185692335	171	55698											
C4orf6	10141	broad.mit.edu	37	chr4	5528039	5528039	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gactgtctccggtgctcactCaactgcagtgcatcaatgaa	10	10	9	12	1	4	1	3	1	1	0	5	2	4	1	1	1	4	3	1	1	3	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:5528039C>G	uc003gii.2	+	2	438	c.263C>G	c.(262-264)TCA>TGA	p.S88*		NM_005750	NP_005741	Q99440	CD006_HUMAN	chromosome 4 open reading frame 6	88					nervous system development						0						GGTGCTCACTCAACTGCAGTG	0.433													14	38					0	0	0	0	G	5528039	G	G	5528039	4	3	303	1	0	0	0	0	0	1	0	0	2288	838	29	2	269	2	C4orf6	4	5528039	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	66098	5528039	185626237	172	55699											
CRMP1	1400	broad.mit.edu	37	chr4	5830225	5830225	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacacactcaccttattcctGattttgacgcgctggtacag	9	12	8	12	2	1	2	1	2	0	0	2	3	2	2	2	1	1	2	2	1	2	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:5830225G>C	uc003gip.2	-	13	1553	c.1452C>G	c.(1450-1452)ATC>ATG	p.I484M	EVC_uc003gim.1_Intron|CRMP1_uc003gin.1_Missense_Mutation_p.I396M|CRMP1_uc003giq.2_Missense_Mutation_p.I484M|CRMP1_uc003gir.2_Missense_Mutation_p.I479M|CRMP1_uc003gis.2_Missense_Mutation_p.I598M	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	484					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		CCTTATTCCTGATTTTGACGC	0.572													13	17					0	0	0	0	C	5830225	C	C	5830225	3	2	303	1	0	0	0	0	1	0	0	0	3905	1280	45	2	278	2	CRMP1	4	5830225	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	302186	5830225	185324051	173	55700											
MAN2B2	23324	broad.mit.edu	37	chr4	6619118	6619118	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tccccaaaggccatcgagggGaagcccaggctgacctccgc	9	4	12	16	2	0	1	0	1	0	0	3	3	2	2	6	4	1	1	6	4	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:6619118G>A	uc003gjf.1	+	17	2749	c.2713G>A	c.(2713-2715)GAA>AAA	p.E905K	MAN2B2_uc003gje.1_Missense_Mutation_p.E905K|MAN2B2_uc011bwf.1_Missense_Mutation_p.E854K	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	905					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						CCATCGAGGGGAAGCCCAGGC	0.582													13	49					0	0	0	0	A	6619118	A	A	6619118	3	1	303	1	0	0	0	0	1	0	0	0	9270	1175	41	2	2779	2	MAN2B2	4	6619118	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	788893	6619118	184535158	174	55701											
KLHL5	51088	broad.mit.edu	37	chr4	39064535	39064535	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggccaatggcatccacctCtgaagtccctgcatttgagt	8	12	9	12	0	1	2	0	2	1	0	3	2	3	2	4	2	1	2	4	2	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:39064535C>T	uc003gts.2	+	1	476	c.401C>T	c.(400-402)TCT>TTT	p.S134F	KLHL5_uc003gtp.2_Missense_Mutation_p.S88F|KLHL5_uc003gtq.2_Intron|KLHL5_uc003gtr.1_Missense_Mutation_p.S134F|KLHL5_uc003gtt.2_Missense_Mutation_p.S134F	NM_015990	NP_057074	Q96PQ7	KLHL5_HUMAN	kelch-like 5 isoform 1	134						cytoplasm|cytoskeleton	actin binding			ovary(1)	1						GCATCCACCTCTGAAGTCCCT	0.463													29	72					0	0	0	0	T	39064535	T	T	39064535	3	4	303	1	0	0	0	0	1	0	0	0	8431	913	32	2	403	2	KLHL5	4	39064535	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	32445417	39064535	152089741	175	55702											
ANKRD17	26057	broad.mit.edu	37	chr4	73986766	73986766	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagcagctgtatgcccattCatagctgctaacatcagagg	12	9	9	11	0	2	1	2	0	0	1	2	1	2	1	1	1	6	5	1	1	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:73986766C>G	uc003hgp.2	-	20	3798	c.3681G>C	c.(3679-3681)ATG>ATC	p.M1227I	ANKRD17_uc003hgo.2_Missense_Mutation_p.M1114I|ANKRD17_uc003hgq.2_Missense_Mutation_p.M976I|ANKRD17_uc003hgr.2_Missense_Mutation_p.M1226I|ANKRD17_uc011cbd.1_Missense_Mutation_p.M792I	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1227	ANK 20.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TATGCCCATTCATAGCTGCTA	0.428													29	68					0	0	0	0	G	73986766	G	G	73986766	3	3	303	1	0	0	0	0	1	0	0	0	646	826	29	2	4190	2	ANKRD17	4	73986766	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	34922231	73986766	117167510	176	55703											
PPEF2	5470	broad.mit.edu	37	chr4	76812835	76812835	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggggatgaagtgatccatGagatagctgaagaagtcatg	13	9	14	5	0	1	5	1	4	0	2	2	7	2	6	1	2	1	1	1	2	4	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:76812835G>T	uc003hix.2	-	4	564	c.207C>A	c.(205-207)CTC>CTA	p.L69L	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Silent_p.L69L	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	69					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AGTGATCCATGAGATAGCTGA	0.517													63	193					5.89852e-23	6.19485e-23	1	0	T	76812835	T	T	76812835	2	4	303	1	0	0	0	0	0	0	0	1	12363	1277	45	2		2	PPEF2	4	76812835	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2826069	76812835	114341441	177	55704											
PTPN13	5783	broad.mit.edu	37	chr4	87655966	87655966	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaggatgcactgtgatgatGagacttccttattgctggca	11	12	11	7	0	0	3	0	3	0	1	1	5	1	4	1	2	2	3	1	2	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:87655966G>A	uc003hpz.2	+	14	2569	c.2089G>A	c.(2089-2091)GAG>AAG	p.E697K	PTPN13_uc003hpy.2_Missense_Mutation_p.E697K|PTPN13_uc003hqa.2_Missense_Mutation_p.E697K|PTPN13_uc003hqb.2_Missense_Mutation_p.E697K	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	697	FERM.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CTGTGATGATGAGACTTCCTT	0.413													33	85					0	0	0	0	A	87655966	A	A	87655966	3	1	303	1	0	0	0	0	1	0	0	0	12845	1291	45	2	2139	2	PTPN13	4	87655966	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10843131	87655966	103498310	178	55705											
AFF1	4299	broad.mit.edu	37	chr4	87968316	87968316	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagctttctcccttaatctCtttgccttccccagttcccc	4	15	5	17	0	2	0	0	0	2	0	6	1	4	1	6	1	2	2	6	1	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:87968316C>G	uc003hqj.3	+	3	1015	c.608C>G	c.(607-609)TCT>TGT	p.S203C	AFF1_uc011ccx.1_Missense_Mutation_p.S144C|AFF1_uc003hqh.1_Missense_Mutation_p.S210C|AFF1_uc011ccy.1_Missense_Mutation_p.S210C|AFF1_uc011ccz.1_Missense_Mutation_p.S210C|AFF1_uc003hqk.3_Missense_Mutation_p.S203C|AFF1_uc011cda.1_Intron	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	203						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CCCTTAATCTCTTTGCCTTCC	0.527													37	103					0	0	0	0	G	87968316	G	G	87968316	3	3	303	1	0	0	0	0	1	0	0	0	356	913	32	2	660	2	AFF1	4	87968316	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	312350	87968316	103185960	179	55706											
HERC3	8916	broad.mit.edu	37	chr4	89599159	89599159	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaatgtcttcatgcttctCaccctggagcctctgctggc	6	12	9	14	0	4	1	2	0	3	1	5	2	4	2	2	2	3	2	2	2	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:89599159C>T	uc003hrw.1	+	19	2236	c.2070C>T	c.(2068-2070)CTC>CTT	p.L690L	HERC3_uc011cdn.1_Silent_p.L572L|HERC3_uc011cdo.1_Silent_p.L134L	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	690					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TCATGCTTCTCACCCTGGAGC	0.527													14	46					0	0	0	0	T	89599159	T	T	89599159	2	4	303	1	0	0	0	0	0	0	0	1	7098	813	29	2		2	HERC3	4	89599159	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1630843	89599159	101555117	180	55707											
ADH4	127	broad.mit.edu	37	chr4	100052672	100052672	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	taccatggtttcagatccacCtgcacagtcaagggcaaaat	13	9	8	11	0	2	1	2	0	0	1	3	1	3	1	3	2	2	3	3	2	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:100052672C>T	uc003hun.2	-	6	902	c.826G>A	c.(826-828)GGT>AGT	p.G276S	uc003hum.1_Intron|ADH4_uc011ced.1_Missense_Mutation_p.G295S	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	276					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	TCAGATCCACCTGCACAGTCA	0.388													14	39					0	0	0	0	T	100052672	T	T	100052672	3	4	303	1	0	0	0	0	1	0	0	0	310	681	24	4	332	4	ADH4	4	100052672	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	10453513	100052672	91101604	181	55708											
CENPE	1062	broad.mit.edu	37	chr4	104070394	104070394	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttcacttcctcataattttCattaagtttctgagccaact	10	18	3	10	0	4	1	3	1	1	0	5	1	5	1	2	0	2	1	2	0	3	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:104070394C>T	uc003hxb.1	-	27	3658	c.3568G>A	c.(3568-3570)GAA>AAA	p.E1190K	CENPE_uc003hxc.1_Missense_Mutation_p.E1165K	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1190	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TCATAATTTTCATTAAGTTTC	0.308													9	35					0	0	0	0	T	104070394	T	T	104070394	3	4	303	1	0	0	0	0	1	0	0	0	3245	835	29	2	4629	2	CENPE	4	104070394	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4017722	104070394	87083882	182	55709											
SEC24B	10427	broad.mit.edu	37	chr4	110459742	110459742	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccattaagtccaatccttCacatagtaaagtaagtactt	15	12	5	9	0	1	0	1	0	0	0	3	1	3	0	3	0	1	3	3	0	7	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:110459742C>T	uc003hzk.2	+	23	3737	c.3682C>T	c.(3682-3684)CAC>TAC	p.H1228Y	SEC24B_uc003hzl.2_Missense_Mutation_p.H1193Y|SEC24B_uc011cfp.1_Missense_Mutation_p.H1258Y|SEC24B_uc011cfq.1_Missense_Mutation_p.H1227Y|SEC24B_uc011cfr.1_Missense_Mutation_p.H1192Y	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	1228					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TCCAATCCTTCACATAGTAAA	0.363													20	39					0	0	0	0	T	110459742	T	T	110459742	3	4	303	1	0	0	0	0	1	0	0	0	14060	826	29	2	3772	2	SEC24B	4	110459742	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6389348	110459742	80694534	183	55710											
EGF	1950	broad.mit.edu	37	chr4	110932483	110932483	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggtaatggagcgaagctttCatatgccctcctatgggaca	11	10	11	9	1	1	0	1	0	0	0	2	3	2	2	2	3	3	2	2	3	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:110932483C>T	uc003hzy.3	+	24	3948	c.3496C>T	c.(3496-3498)CAT>TAT	p.H1166Y	EGF_uc011cfu.1_Missense_Mutation_p.H1124Y|EGF_uc011cfv.1_Missense_Mutation_p.H1125Y|EGF_uc010imk.2_3'UTR	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	1166	Cytoplasmic (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GCGAAGCTTTCATATGCCCTC	0.552													22	56					0	0	0	0	T	110932483	T	T	110932483	3	4	303	1	0	0	0	0	1	0	0	0	4984	826	29	2	3590	2	EGF	4	110932483	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	472741	110932483	80221793	184	55711											
PRSS12	8492	broad.mit.edu	37	chr4	119273873	119273873	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcacgaagcgggcgagcgtCatggtgccagcgctgcgggg	7	4	19	11	6	1	0	1	0	0	0	1	2	1	0	1	4	6	2	1	4	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:119273873C>T	uc003ica.1	-	1	50	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	1						membrane	scavenger receptor activity			skin(1)	1						GGGCGAGCGTCATGGTGCCAG	0.672													8	21					0	0	0	0	T	119273873	T	T	119273873	3	4	303	1	0	0	0	0	1	0	0	0	12677	826	29	2	2676	2	PRSS12	4	119273873	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	8341390	119273873	71880403	185	55712											
FGF2	2247	broad.mit.edu	37	chr4	123813550	123813550	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccaatgtctgctaagagctGattttaatggccacatctaa	12	13	7	9	0	2	2	0	1	2	1	3	2	3	2	2	1	2	2	2	1	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:123813550G>A	uc003iev.1	+	3	934	c.866G>A	c.(865-867)TGA>TAA	p.*289*		NM_002006	NP_001997	P09038	FGF2_HUMAN	fibroblast growth factor 2	289					activation of MAPK activity|branching involved in ureteric bud morphogenesis|cell migration involved in sprouting angiogenesis|chemotaxis|chondroblast differentiation|embryonic morphogenesis|fibroblast growth factor receptor signaling pathway|inositol phosphate biosynthetic process|insulin receptor signaling pathway|negative regulation of blood vessel endothelial cell migration|negative regulation of cell death|organ morphogenesis|phosphatidylinositol biosynthetic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cardiac muscle cell proliferation|positive regulation of cell division|positive regulation of cell fate specification|positive regulation of ERK1 and ERK2 cascade|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phospholipase C activity|Ras protein signal transduction|release of sequestered calcium ion into cytosol|wound healing	extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|lung(1)|central_nervous_system(1)	3					Pentosan Polysulfate(DB00686)	GCTAAGAGCTGATTTTAATGG	0.353													15	68					0	0	0	0	A	123813550	A	A	123813550	2	1	303	1	0	0	0	0	0	0	0	1	5880	1285	45	2		2	FGF2	4	123813550	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4539677	123813550	67340726	186	55713											
PHF17	79960	broad.mit.edu	37	chr4	129764189	129764189	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatgaagatcgaaagccttCagaggtacttcttgaatgct	13	11	9	8	1	2	4	1	2	1	2	3	5	2	4	1	1	3	2	1	1	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:129764189C>T	uc003igk.2	+	3	414	c.134C>T	c.(133-135)TCA>TTA	p.S45L	PHF17_uc003igj.2_Missense_Mutation_p.S45L|PHF17_uc003igl.2_Missense_Mutation_p.S45L|PHF17_uc011cgy.1_Missense_Mutation_p.S45L|PHF17_uc003igm.2_Missense_Mutation_p.S45L	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	45					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						CGAAAGCCTTCAGAGGTACTT	0.393													7	13					0	0	0	0	T	129764189	T	T	129764189	3	4	303	1	0	0	0	0	1	0	0	0	11883	838	29	2	140	2	PHF17	4	129764189	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5950639	129764189	61390087	187	55714											
PHF17	79960	broad.mit.edu	37	chr4	129770159	129770159	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgtctgaagagaaatccctCatgttcatcaggcccaagaa	13	9	9	10	0	4	3	3	1	1	2	5	4	5	3	2	1	0	1	2	1	4	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:129770159C>T	uc003igk.2	+	5	601	c.321C>T	c.(319-321)CTC>CTT	p.L107L	PHF17_uc003igj.2_Silent_p.L107L|PHF17_uc003igl.2_Intron|PHF17_uc011cgy.1_Silent_p.L107L|PHF17_uc003igm.2_Silent_p.L107L	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	107					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						AGAAATCCCTCATGTTCATCA	0.517													24	54					0	0	0	0	T	129770159	T	T	129770159	2	4	303	1	0	0	0	0	0	0	0	1	11883	813	29	2		2	PHF17	4	129770159	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5970	129770159	61384117	188	55715											
CCRN4L	25819	broad.mit.edu	37	chr4	139966178	139966178	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaggccgacagttctgcatCgctgttacccatctaaaagc	10	10	8	13	2	3	0	1	0	2	0	4	1	3	0	2	1	3	4	2	1	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:139966178C>T	uc003ihl.2	+	3	1039	c.846C>T	c.(844-846)ATC>ATT	p.I282I		NM_012118	NP_036250	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like	282					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_hematologic(180;0.162)					AGTTCTGCATCGCTGTTACCC	0.532													18	50					0	0	0	0	T	139966178	T	T	139966178	2	4	303	1	0	0	0	0	0	0	0	1	2966	874	31	1		1	CCRN4L	4	139966178	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	10196019	139966178	51188098	189	55716											
TDO2	6999	broad.mit.edu	37	chr4	156841121	156841121	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tactgtgatagctcctacttCagcagtgatgaatcagatta	12	13	8	8	0	2	4	2	3	0	1	3	4	3	4	1	0	4	2	1	0	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:156841121C>T	uc003ipf.1	+	12	1264	c.1200C>T	c.(1198-1200)TTC>TTT	p.F400F		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	400					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	GCTCCTACTTCAGCAGTGATG	0.348													13	35					0	0	0	0	T	156841121	T	T	156841121	2	4	303	1	0	0	0	0	0	0	0	1	15793	825	29	2		2	TDO2	4	156841121	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	16874943	156841121	34313155	190	55717											
ENPP6	133121	broad.mit.edu	37	chr4	185012401	185012401	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacaggcggggcagtgctggCgcggcccttcagcatgcaca	7	5	16	13	3	1	0	1	0	0	0	1	1	1	0	1	5	3	4	1	5	0	1	rs148434007	byFrequency	TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:185012401C>T	uc003iwc.2	-	8	1394	c.1252G>A	c.(1252-1254)GCC>ACC	p.A418T		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	418	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GCAGTGCTGGCGCGGCCCTTC	0.562													17	93					0	0	0	0	T	185012401	T	T	185012401	3	4	303	1	0	0	0	0	1	0	0	0	5158	768	27	1	74	1	ENPP6	4	185012401	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	28171280	185012401	6141875	191	55718											
SORBS2	8470	broad.mit.edu	37	chr4	186536298	186536298	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atgtagacagtatctcctttCttaaatgacaactccctgga	12	13	6	10	0	2	2	0	1	2	1	4	3	3	3	2	1	1	2	2	1	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:186536298C>T	uc003iyl.2	-	16	3513	c.2655G>A	c.(2653-2655)AAG>AAA	p.K885K	SORBS2_uc003iyh.2_Silent_p.K609K|SORBS2_uc011ckw.1_Silent_p.K446K|SORBS2_uc003iyi.2_Silent_p.K516K|SORBS2_uc011ckx.1_Silent_p.K451K|SORBS2_uc003iyk.2_Silent_p.K429K|SORBS2_uc003iym.2_Silent_p.K985K|SORBS2_uc003iyn.1_Silent_p.K476K|SORBS2_uc011cku.1_Silent_p.K277K|SORBS2_uc011ckv.1_Silent_p.K789K|SORBS2_uc003iyd.2_Silent_p.K584K|SORBS2_uc003iye.2_Silent_p.K458K|SORBS2_uc003iya.2_Silent_p.K405K|SORBS2_uc003iyb.2_Silent_p.K358K|SORBS2_uc003iyc.2_Silent_p.K338K|SORBS2_uc003iyg.2_Silent_p.K999K|SORBS2_uc003iyf.2_Silent_p.K421K|SORBS2_uc003iyo.1_Silent_p.K334K	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	885	SH3 1.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TATCTCCTTTCTTAAATGACA	0.433													11	32					0	0	0	0	T	186536298	T	T	186536298	2	4	303	1	0	0	0	0	0	0	0	1	14992	912	32	2		2	SORBS2	4	186536298	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1523897	186536298	4617978	192	55719											
FAT1	2195	broad.mit.edu	37	chr4	187630533	187630533	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacgctgtatgaggtgggtGagaataacggtctcaagtca	13	9	13	6	2	2	2	2	2	1	1	3	3	2	2	0	3	2	2	0	3	5	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr4:187630533G>C	uc003izf.2	-	2	637	c.449C>G	c.(448-450)TCA>TGA	p.S150*	FAT1_uc010iso.1_Nonsense_Mutation_p.S150*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	150	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGAGGTGGGTGAGAATAACGG	0.463										HNSCC(5;0.00058)			45	79					0	0	0	0	C	187630533	C	C	187630533	4	2	303	1	0	0	0	0	0	1	0	0	5721	1294	45	2	13421	2	FAT1	4	187630533	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1094235	187630533	3523743	193	55720											
CCT5	22948	broad.mit.edu	37	chr5	10264799	10264799	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcatgtcatagaaaccttGattggcaaaaagcaacagat	17	8	8	8	0	1	3	1	1	0	2	1	3	1	3	1	1	4	3	1	1	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:10264799G>C	uc003jeq.2	+	11	1701	c.1530G>C	c.(1528-1530)TTG>TTC	p.L510F	CCT5_uc003jer.2_3'UTR|CCT5_uc010its.2_3'UTR|CCT5_uc011cmr.1_Missense_Mutation_p.L455F|CCT5_uc011cms.1_Missense_Mutation_p.L472F|CCT5_uc011cmt.1_Missense_Mutation_p.L417F	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	510					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						TAGAAACCTTGATTGGCAAAA	0.338													16	57					0	0	0	0	C	10264799	C	C	10264799	3	2	303	1	0	0	0	0	1	0	0	0	2971	1281	45	2	1572	2	CCT5	5	10264799	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08		10264799	170650461	194	55721											
C5orf22	55322	broad.mit.edu	37	chr5	31535864	31535864	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttccagagaattaagtattGaaaattggattatgcctgca	14	14	8	5	0	0	2	0	1	0	1	1	4	1	3	2	1	2	2	2	1	6	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:31535864G>C	uc003jhj.3	+	3	368	c.241G>C	c.(241-243)GAA>CAA	p.E81Q	C5orf22_uc011cnw.1_RNA|C5orf22_uc003jhk.3_5'UTR	NM_018356	NP_060826	Q49AR2	CE022_HUMAN	hypothetical protein LOC55322	81										ovary(2)	2						ATTAAGTATTGAAAATTGGAT	0.343													12	13					0	0	0	0	C	31535864	C	C	31535864	3	2	303	1	0	0	0	0	1	0	0	0	2295	1291	45	2	251	2	C5orf22	5	31535864	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	21271065	31535864	149379396	195	55722											
MTMR12	54545	broad.mit.edu	37	chr5	32312866	32312866	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcgcggcgccccctcacctCagggcgtacgtacgacacga	7	5	12	17	7	2	0	2	0	0	0	2	2	2	0	3	2	3	2	3	2	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:32312866C>T	uc003jhq.2	-	1	249	c.79G>A	c.(79-81)GAG>AAG	p.E27K	MTMR12_uc010iuk.2_Missense_Mutation_p.E27K|MTMR12_uc010iul.2_Missense_Mutation_p.E27K	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	27						cytoplasm	phosphatase activity			ovary(1)	1						ccccTCACCTCAGGGCGTACG	0.502													8	33					0	0	0	0	T	32312866	T	T	32312866	3	4	303	1	0	0	0	0	1	0	0	0	9994	835	29	2	2228	2	MTMR12	5	32312866	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	777002	32312866	148602394	196	55723											
NIPBL	25836	broad.mit.edu	37	chr5	36985872	36985872	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatctgatagttcaaaaactGataaactagaacgaaaacac	21	8	5	7	1	2	3	1	2	1	1	2	4	2	3	0	0	4	1	0	0	10	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:36985872G>A	uc003jkl.3	+	10	3089	c.2590G>A	c.(2590-2592)GAT>AAT	p.D864N	NIPBL_uc003jkk.3_Missense_Mutation_p.D864N|NIPBL_uc003jkm.1_Missense_Mutation_p.D743N	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	864					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TTCAAAAACTGATAAACTAGA	0.423													7	16					0	0	0	0	A	36985872	A	A	36985872	3	1	303	1	0	0	0	0	1	0	0	0	10482	1290	45	2	2624	2	NIPBL	5	36985872	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4673006	36985872	143929388	197	55724											
OSMR	9180	broad.mit.edu	37	chr5	38933203	38933203	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacctataaccaggcagcttCtgactctggctcttgtggcc	7	11	10	13	0	3	1	0	1	3	0	3	2	3	1	3	3	2	3	3	3	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:38933203C>T	uc003jln.1	+	18	2964	c.2597C>T	c.(2596-2598)TCT>TTT	p.S866F	OSMR_uc011cpj.1_Missense_Mutation_p.S70F	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	866	Cytoplasmic (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					CAGGCAGCTTCTGACTCTGGC	0.463													39	89					0	0	0	0	T	38933203	T	T	38933203	3	4	303	1	0	0	0	0	1	0	0	0	11346	913	32	2	2701	2	OSMR	5	38933203	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1947331	38933203	141982057	198	55725											
TTC33	23548	broad.mit.edu	37	chr5	40716372	40716372	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttgctgaaactgtcttctCtttctcagcaatagctgcac	9	15	6	11	0	3	1	1	1	3	0	5	1	3	1	0	0	5	4	0	0	3	4	rs141546911		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:40716372C>G	uc003jma.2	-	5	812	c.664G>C	c.(664-666)GAG>CAG	p.E222Q	TTC33_uc011cpm.1_Missense_Mutation_p.E114Q|TTC33_uc010ivg.2_3'UTR	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	222							binding			ovary(1)	1						ACTGTCTTCTCTTTCTCAGCA	0.423													14	50					0	0	0	0	G	40716372	G	G	40716372	3	3	303	1	0	0	0	0	1	0	0	0	16770	922	32	2	128	2	TTC33	5	40716372	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1783169	40716372	140198888	199	55726											
NNT	23530	broad.mit.edu	37	chr5	43656905	43656905	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggttcagtgtctgctctctCtgctgtcatggtaagaagtc	6	14	12	9	0	5	1	2	0	3	1	7	1	5	1	0	2	2	4	0	2	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:43656905C>G	uc003joe.2	+	16	2699	c.2444C>G	c.(2443-2445)TCT>TGT	p.S815C	NNT_uc003jof.2_Missense_Mutation_p.S815C	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	815	Helical; (Potential).				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	TCTGCTCTCTCTGCTGTCATG	0.423													24	53					0	0	0	0	G	43656905	G	G	43656905	3	3	303	1	0	0	0	0	1	0	0	0	10564	913	32	2	2502	2	NNT	5	43656905	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2940533	43656905	137258355	200	55727											
DHX29	54505	broad.mit.edu	37	chr5	54558484	54558484	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtataagagccatccatGagtttgcaaatctcgattta	12	13	8	8	1	1	2	0	1	1	1	3	3	2	2	2	1	2	3	2	1	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:54558484G>C	uc003jpx.2	-	24	3922	c.3802C>G	c.(3802-3804)CAT>GAT	p.H1268D	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	1268							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				AGCCATCCATGAGTTTGCAAA	0.423													28	84					0	0	0	0	C	54558484	C	C	54558484	3	2	303	1	0	0	0	0	1	0	0	0	4525	1290	45	2	323	2	DHX29	5	54558484	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10901579	54558484	126356776	201	55728											
PIK3R1	5295	broad.mit.edu	37	chr5	67589627	67589627	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagaaaaaagtcgagaatatGatagattatatgaagaatat	22	10	8	1	1	0	6	0	2	0	4	1	7	0	6	0	0	0	0	0	0	12	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:67589627G>A	uc003jva.2	+	11	1950	c.1390G>A	c.(1390-1392)GAT>AAT	p.D464N	PIK3R1_uc003jvb.2_Missense_Mutation_p.D464N|PIK3R1_uc003jvc.2_Missense_Mutation_p.D164N|PIK3R1_uc003jvd.2_Missense_Mutation_p.D194N|PIK3R1_uc003jve.2_Missense_Mutation_p.D143N|PIK3R1_uc011crb.1_Missense_Mutation_p.D134N	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	464					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.D464fs*2(1)|p.?(1)|p.D464H(1)|p.Y463_L466del(1)|p.T454_D464del(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TCGAGAATATGATAGATTATA	0.294			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			10	27					0	0	0	0	A	67589627	A	A	67589627	3	1	303	1	0	0	0	0	1	0	0	0	11973	1290	45	2	1558	2	PIK3R1	5	67589627	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	13031143	67589627	113325633	202	55729											
CCNB1	891	broad.mit.edu	37	chr5	68470931	68470931	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttccttcggagagcatctaaGattggagaggtacaggtttc	10	12	12	7	1	1	3	0	0	1	3	4	5	2	3	1	4	2	3	1	4	2	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:68470931G>C	uc003jvm.2	+	6	1110	c.933G>C	c.(931-933)AAG>AAC	p.K311N	CCNB1_uc011crd.1_Missense_Mutation_p.K311N|CCNB1_uc010ixb.2_Missense_Mutation_p.K311N	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	311					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		GAGCATCTAAGATTGGAGAGG	0.453													25	50					0	0	0	0	C	68470931	C	C	68470931	3	2	303	1	0	0	0	0	1	0	0	0	2926	933	33	2	955	2	CCNB1	5	68470931	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	881304	68470931	112444329	203	55730											
TMEM161B	153396	broad.mit.edu	37	chr5	87492275	87492275	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccactggtaaggtagagataGattctggataaataccccag	14	9	10	8	0	1	2	0	0	1	2	1	4	1	3	3	3	1	2	3	3	6	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:87492275G>A	uc003kjc.2	-	12	1342	c.1217C>T	c.(1216-1218)TCT>TTT	p.S406F	TMEM161B_uc011cty.1_Missense_Mutation_p.S395F|TMEM161B_uc010jax.2_RNA|TMEM161B_uc011ctx.1_Missense_Mutation_p.S197F	NM_153354	NP_699185	Q8NDZ6	T161B_HUMAN	transmembrane protein 161B	406						integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)		GGTAGAGATAGATTCTGGATA	0.318													10	38					0	0	0	0	A	87492275	A	A	87492275	3	1	303	1	0	0	0	0	1	0	0	0	16143	942	33	2	250	2	TMEM161B	5	87492275	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	19021344	87492275	93422985	204	55731											
GPR98	84059	broad.mit.edu	37	chr5	90012484	90012484	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagaagtgaattcctcaaatGaatctaaagatctgactcct	15	11	6	9	0	3	5	1	3	2	2	5	5	5	5	2	0	0	0	2	0	6	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:90012484G>A	uc003kju.2	+	43	9481	c.9385G>A	c.(9385-9387)GAA>AAA	p.E3129K	GPR98_uc003kjt.2_Missense_Mutation_p.E835K|GPR98_uc003kjv.2_Missense_Mutation_p.E729K	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3129	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTCCTCAAATGAATCTAAAGA	0.383													7	23					0	0	0	0	A	90012484	A	A	90012484	3	1	303	1	0	0	0	0	1	0	0	0	6760	1291	45	2	9555	2	GPR98	5	90012484	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2520209	90012484	90902776	205	55732											
C5orf36	285600	broad.mit.edu	37	chr5	93856022	93856022	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaccacacgaacagcattttCtctgaactgcagctcacaaa	15	8	5	13	1	2	1	1	1	1	0	3	2	2	1	1	0	6	3	1	0	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:93856022C>T	uc011cuk.1	-	5	1158	c.901G>A	c.(901-903)GAA>AAA	p.E301K	C5orf36_uc003kkp.2_Missense_Mutation_p.E301K	NM_001145678	NP_001139150	Q8IV33	K0825_HUMAN	hypothetical protein LOC285600 isoform 1	301											0		all_cancers(142;2.12e-08)|all_epithelial(76;5.95e-11)|all_lung(232;0.000996)|Lung NSC(167;0.0108)|Ovarian(174;0.0218)|Colorectal(57;0.0329)|Breast(839;0.214)|Lung SC(612;0.236)		all cancers(79;3.96e-19)		ACAGCATTTTCTCTGAACTGC	0.363													17	38					0	0	0	0	T	93856022	T	T	93856022	3	4	303	1	0	0	0	0	1	0	0	0	2305	922	32	2	2999	2	C5orf36	5	93856022	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3843538	93856022	87059238	206	55733											
SPATA9	83890	broad.mit.edu	37	chr5	94994347	94994347	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagatttgctcattcatttCagctgattggtcaaacacag	11	14	7	9	0	5	2	5	1	0	1	5	2	5	2	0	1	3	2	0	1	1	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:94994347C>T	uc003klj.1	-	5	901	c.745G>A	c.(745-747)GAA>AAA	p.E249K	SPATA9_uc010jbh.1_Intron|SPATA9_uc003klh.1_RNA|SPATA9_uc003kli.1_RNA	NM_031952	NP_114158	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	249					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane					0		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		TCATTCATTTCAGCTGATTGG	0.363													12	23					0	0	0	0	T	94994347	T	T	94994347	3	4	303	1	0	0	0	0	1	0	0	0	15082	835	29	2	23	2	SPATA9	5	94994347	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1138325	94994347	85920913	207	55734											
RIOK2	55781	broad.mit.edu	37	chr5	96518855	96518855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcaagaccctgaagtcatctCggctcatgtaacgcaacttg	11	10	8	12	2	4	2	3	1	1	1	5	2	4	2	1	1	2	3	1	1	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:96518855C>T	uc003kmz.2	-	1	151	c.41G>A	c.(40-42)CGA>CAA	p.R14Q	RIOK2_uc003kna.3_Missense_Mutation_p.R14Q	NM_018343	NP_060813	Q9BVS4	RIOK2_HUMAN	RIO kinase 2 isoform 1	14							ATP binding|protein serine/threonine kinase activity			kidney(1)	1		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		GAAGTCATCTCGGCTCATGTA	0.562													56	191					0	0	0	0	T	96518855	T	T	96518855	3	4	303	1	0	0	0	0	1	0	0	0	13443	884	31	1	1685	1	RIOK2	5	96518855	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1524508	96518855	84396405	208	55735											
DCP2	167227	broad.mit.edu	37	chr5	112343710	112343710	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agaaaagaacaaatgggcttCagccagcaaagcagcagaat	19	4	10	8	0	1	3	1	0	0	3	1	3	1	3	1	1	5	4	1	1	6	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:112343710C>T	uc003kqh.2	+	9	1216	c.1018C>T	c.(1018-1020)CAG>TAG	p.Q340*	DCP2_uc011cwa.1_Nonsense_Mutation_p.Q129*|DCP2_uc010jcc.2_Intron	NM_152624	NP_689837	Q8IU60	DCP2_HUMAN	DCP2 decapping enzyme	340					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|protein binding|RNA binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		AAATGGGCTTCAGCCAGCAAA	0.383													13	34					0	0	0	0	T	112343710	T	T	112343710	4	4	303	1	0	0	0	0	0	1	0	0	4317	827	29	2	1052	2	DCP2	5	112343710	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	15824855	112343710	68571550	209	55736											
YTHDC2	64848	broad.mit.edu	37	chr5	112876706	112876706	+	Missense_Mutation	SNP	C	G	G																															ttacagaatggtactcagctCaagaaaatagtttcaagcct																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:112876706C>G	uc003kqn.2	+	9	1435	c.1252C>G	c.(1252-1254)CAA>GAA	p.Q418E	YTHDC2_uc010jce.1_Missense_Mutation_p.Q418E|YTHDC2_uc010jcf.1_Missense_Mutation_p.Q118E	NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	418							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		GTACTCAGCTCAAGAAAATAG	0.348													19	29					0	0	0	0	G	112876706	G	G	112876706	3	3	303	1	0	0	0	0	1	0	0	0	17565	827	29	2	1286	2	YTHDC2	5	112876706	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	532996	112876706	68038554	210	55737	131	2									
YTHDC2	64848	broad.mit.edu	37	chr5	112876709	112876709	+	Missense_Mutation	SNP	G	C	C																															cagaatggtactcagctcaaGaaaatagtttcaagcctgaa																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:112876709G>C	uc003kqn.2	+	9	1438	c.1255G>C	c.(1255-1257)GAA>CAA	p.E419Q	YTHDC2_uc010jce.1_Missense_Mutation_p.E419Q|YTHDC2_uc010jcf.1_Missense_Mutation_p.E119Q	NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	419							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		CTCAGCTCAAGAAAATAGTTT	0.353													20	31					0	0	0	0	C	112876709	C	C	112876709	3	2	303	1	0	0	0	0	1	0	0	0	17565	943	33	2	1289	2	YTHDC2	5	112876709	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3	112876709	68038551	211	55738	131	2									
C5orf56	441108	broad.mit.edu	37	chr5	131822133	131822133	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaagacatcgagcgcccTccgaccaaccctgcagcctg	9	6	9	17	3	0	1	0	0	0	1	2	3	1	1	5	0	5	2	5	0	2	1	rs9282763	byFrequency	TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:131822133T>C	uc010jds.1	+	4	469	c.294T>C	c.(292-294)CCT>CCC	p.P98P	IRF1_uc003kxd.2_Intron|IRF1_uc003kxa.2_Intron|IRF1_uc003kxb.2_Intron|IRF1_uc010jdt.1_Intron			Q8N8D9	CE056_HUMAN	Homo sapiens full length insert cDNA clone ZA99C08.	Error:Variant_position_missing_in_Q8N8D9_after_alignment											0						TCGAGCGCCCTCCGACCAACC	0.577													6	25					0	0	0	0	C	131822133	C	C	131822133	2	2	303	1	0	0	0	0	0	0	0	1	2322	1566	54	5		5	C5orf56	5	131822133	Silent	SNP	T	TCGA-HL-7533-01A-11D-2229-08	18945424	131822133	49093127	212	55739											
DDX46	9879	broad.mit.edu	37	chr5	134130685	134130685	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggcaggagtgtggtttgctCagatgtggagcaacaagtgg	10	9	17	5	0	1	1	1	0	0	1	1	3	1	3	0	5	3	4	0	5	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:134130685C>G	uc003kzw.2	+	14	1940	c.1772C>G	c.(1771-1773)TCA>TGA	p.S591*	DDX46_uc003kzv.1_RNA	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	591					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTGGTTTGCTCAGATGTGGAG	0.443													20	86					0	0	0	0	G	134130685	G	G	134130685	4	3	303	1	0	0	0	0	0	1	0	0	4381	838	29	2	1826	2	DDX46	5	134130685	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2308552	134130685	46784575	213	55740											
C5orf24	134553	broad.mit.edu	37	chr5	134190687	134190687	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagagctgctgatcagtttGacatatattcctcccagcaa	11	12	8	10	0	1	3	1	3	0	1	3	4	3	3	2	0	3	4	2	0	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:134190687G>C	uc003kzx.2	+	2	158	c.97G>C	c.(97-99)GAC>CAC	p.D33H	C5orf24_uc003kzy.3_Missense_Mutation_p.D33H|C5orf24_uc003kzz.2_Missense_Mutation_p.D33H	NM_152409	NP_689622	Q7Z6I8	CE024_HUMAN	hypothetical protein LOC134553	33											0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGATCAGTTTGACATATATTC	0.468													43	141					0	0	0	0	C	134190687	C	C	134190687	3	2	303	1	0	0	0	0	1	0	0	0	2297	1290	45	2	99	2	C5orf24	5	134190687	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	60002	134190687	46724573	214	55741											
EGR1	1958	broad.mit.edu	37	chr5	137802774	137802774	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacccaccttccccacgccGaacactgacattttccctga	9	8	5	19	2	0	2	0	2	0	0	2	3	2	2	6	0	1	1	6	0	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:137802774G>T	uc003ldb.1	+	2	906	c.636G>T	c.(634-636)CCG>CCT	p.P212P	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	212					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			TCCCCACGCCGAACACTGACA	0.667													54	190					9.53978e-28	1.00551e-27	1	0	T	137802774	T	T	137802774	2	4	303	1	0	0	0	0	0	0	0	1	4993	1045	37	3		3	EGR1	5	137802774	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3612087	137802774	43112486	215	55742											
EGR1	1958	broad.mit.edu	37	chr5	137802793	137802793	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cgaacactgacattttccctGagccacaaagccaggccttc	11	8	7	15	1	0	2	0	2	0	0	2	3	1	2	4	1	3	0	4	1	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:137802793G>T	uc003ldb.1	+	2	925	c.655G>T	c.(655-657)GAG>TAG	p.E219*	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	219					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CATTTTCCCTGAGCCACAAAG	0.642													55	185					1.3268e-25	1.39513e-25	1	0	T	137802793	T	T	137802793	4	4	303	1	0	0	0	0	0	1	0	0	4993	1291	45	2	661	2	EGR1	5	137802793	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	19	137802793	43112467	216	55743											
PCDHA7	56141	broad.mit.edu	37	chr5	140215185	140215185	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccttcaagaattactattCattggtgctggacagcgctc	10	12	8	11	1	2	1	2	0	0	1	3	2	2	2	1	2	3	2	1	2	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:140215185C>A	uc003lhq.2	+	1	1217	c.1217C>A	c.(1216-1218)TCA>TAA	p.S406*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Nonsense_Mutation_p.S406*	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	406	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATTACTATTCATTGGTGCTG	0.587													52	114					6.3091e-27	6.64196e-27	1	0	A	140215185	A	A	140215185	4	1	303	1	0	0	0	0	0	1	0	0	11583	838	29	2	1219	2	PCDHA7	5	140215185	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2412392	140215185	40700075	217	55744											
PCDHGB1	56104	broad.mit.edu	37	chr5	140730835	140730835	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaatagaaattgttgacgaGaatgacaatgccccagaggt	16	8	10	7	1	0	5	0	2	0	3	0	6	0	5	2	1	1	1	2	1	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:140730835G>C	uc003ljo.1	+	1	1008	c.1008G>C	c.(1006-1008)GAG>GAC	p.E336D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.E336D	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	336	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTTGACGAGAATGACAATG	0.423													12	22					0	0	0	0	C	140730835	C	C	140730835	3	2	303	1	0	0	0	0	1	0	0	0	11616	933	33	2	1010	2	PCDHGB1	5	140730835	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	515650	140730835	40184425	218	55745											
PCDHGA6	56109	broad.mit.edu	37	chr5	140754080	140754080	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	aattggaagtgaaaattctcGaaaacgcagctccatcctct	14	10	7	10	2	2	1	0	1	2	0	5	3	4	2	2	1	2	2	2	1	6	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:140754080G>C	uc003ljy.1	+	1	430	c.430G>C	c.(430-432)GAA>CAA	p.E144Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.E144Q	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	144	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAATTCTCGAAAACGCAGC	0.423													11	22					0	0	0	0	C	140754080	C	C	140754080	3	2	303	1	0	0	0	0	1	0	0	0	11612	1059	37	3	432	3	PCDHGA6	5	140754080	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	23245	140754080	40161180	219	55746											
FBXO38	81545	broad.mit.edu	37	chr5	147803613	147803613	+	Silent	SNP	G	A	A																															gatggagaggtggtggccgaGagtggaaataatactccagc																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:147803613G>A	uc003lpf.1	+	13	1791	c.1671G>A	c.(1669-1671)GAG>GAA	p.E557E	FBXO38_uc003lpg.1_Silent_p.E557E|FBXO38_uc003lph.2_Silent_p.E557E	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	557						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGGCCGAGAGTGGAAATA	0.403													24	58					0	0	0	0	A	147803613	A	A	147803613	2	1	303	1	0	0	0	0	0	0	0	1	5778	933	33	2		2	FBXO38	5	147803613	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7049533	147803613	33111647	220	55747	132	2									
FBXO38	81545	broad.mit.edu	37	chr5	147803618	147803618	+	Missense_Mutation	SNP	G	A	A																															agaggtggtggccgagagtgGaaataatactccagctcaca																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:147803618G>A	uc003lpf.1	+	13	1796	c.1676G>A	c.(1675-1677)GGA>GAA	p.G559E	FBXO38_uc003lpg.1_Missense_Mutation_p.G559E|FBXO38_uc003lph.2_Missense_Mutation_p.G559E	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	559						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGAGAGTGGAAATAATACT	0.403													25	64					0	0	0	0	A	147803618	A	A	147803618	3	1	303	1	0	0	0	0	1	0	0	0	5778	1174	41	2	1722	2	FBXO38	5	147803618	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5	147803618	33111642	221	55748	132	2									
FBXO38	81545	broad.mit.edu	37	chr5	147820025	147820025	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	attcttccctgaagccactcGaagtgaagaagacttaaaga	15	9	8	9	1	1	5	0	2	1	3	3	6	2	5	2	0	1	0	2	0	6	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:147820025G>A	uc003lpf.1	+	20	3329	c.3209G>A	c.(3208-3210)CGA>CAA	p.R1070Q	FBXO38_uc003lpg.1_Missense_Mutation_p.R995Q|FBXO38_uc003lph.2_Missense_Mutation_p.R825Q	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	1070						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGCCACTCGAAGTGAAGAA	0.353													11	29					0	0	0	0	A	147820025	A	A	147820025	3	1	303	1	0	0	0	0	1	0	0	0	5778	1058	37	1	3283	1	FBXO38	5	147820025	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	16407	147820025	33095235	222	55749											
SLC6A7	6534	broad.mit.edu	37	chr5	149589169	149589169	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	attgcagaggaggaggagtcGatgatgtgaggcaggaggca	12	6	19	4	1	0	3	0	2	0	1	1	8	0	7	0	6	1	3	0	6	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:149589169G>C	uc003lrr.2	+	14	2273	c.1902G>C	c.(1900-1902)TCG>TCC	p.S634S		NM_014228	NP_055043	Q99884	SC6A7_HUMAN	solute carrier family 6, member 7	634	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity				0		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	AGGAGGAGTCGATGATGTGAG	0.602													3	10					0	0	0	0	C	149589169	C	C	149589169	2	2	303	1	0	0	0	0	0	0	0	1	14753	1045	37	3		3	SLC6A7	5	149589169	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1769144	149589169	31326091	223	55750											
CAMK2A	815	broad.mit.edu	37	chr5	149602274	149602274	+	Nonstop_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcgaccccagcctggtccctCagctgtaagacacacacggg	9	5	11	16	2	1	1	1	0	0	1	2	2	2	1	4	2	2	2	4	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:149602274C>G	uc003lru.2	-	18	1651	c.1436G>C	c.(1435-1437)TGA>TCA	p.*479S	CAMK2A_uc003lrs.2_Nonstop_Mutation_p.*190S|CAMK2A_uc003lrt.2_Nonstop_Mutation_p.*490S	NM_171825	NP_741960	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II	479					interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTGGTCCCTCAGCTGTAAGA	0.602													8	38					0	0	0	0	G	149602274	G	G	149602274	4	3	303	1	0	0	0	0	0	0	0	0	2611	837	29	2	4	2	CAMK2A	5	149602274	Nonstop_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	13105	149602274	31312986	224	55751											
GLRA1	2741	broad.mit.edu	37	chr5	151231080	151231080	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atccatgagaggatgacaatGagcaggctgggaatatacat	15	8	12	6	0	0	3	0	3	0	1	1	6	1	5	1	3	2	2	1	3	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:151231080G>A	uc003lut.2	-	7	1070	c.783C>T	c.(781-783)CTC>CTT	p.L261L	GLRA1_uc003lur.2_Silent_p.L261L|GLRA1_uc003lus.2_Silent_p.L178L	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	261	Helical; (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGATGACAATGAGCAGGCTGG	0.522													25	69					0	0	0	0	A	151231080	A	A	151231080	2	1	303	1	0	0	0	0	0	0	0	1	6491	1277	45	2		2	GLRA1	5	151231080	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1628806	151231080	29684180	225	55752											
LARP1	23367	broad.mit.edu	37	chr5	154188023	154188023	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctttctttcccatcagagcgGaaacgcttgggcattggcca	8	11	10	12	2	2	1	1	0	1	1	3	2	3	2	2	3	2	2	2	3	1	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:154188023G>A	uc003lvp.2	+	16	3132	c.2703G>A	c.(2701-2703)CGG>CGA	p.R901R	LARP1_uc003lvo.2_Silent_p.R824R	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	901							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CATCAGAGCGGAAACGCTTGG	0.498													12	31					0	0	0	0	A	154188023	A	A	154188023	2	1	303	1	0	0	0	0	0	0	0	1	8668	1161	41	2		2	LARP1	5	154188023	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2956943	154188023	26727237	226	55753											
KIF4B	285643	broad.mit.edu	37	chr5	154393474	154393474	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggcactgcgttgtcgccctCtggtccccaaagagattagc	7	10	11	13	2	1	1	0	0	1	1	3	2	2	1	3	2	2	2	3	2	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:154393474C>G	uc010jih.1	+	1	215	c.55C>G	c.(55-57)CTG>GTG	p.L19V		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	19	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTGTCGCCCTCTGGTCCCCAA	0.532													27	47					0	0	0	0	G	154393474	G	G	154393474	3	3	303	1	0	0	0	0	1	0	0	0	8343	912	32	2	57	2	KIF4B	5	154393474	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	205451	154393474	26521786	227	55754											
GABRB2	2561	broad.mit.edu	37	chr5	160972244	160972244	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatactcaccatattgacttCagaaaccatatcgatgctgg	14	11	6	10	1	2	2	2	1	0	1	3	3	2	2	2	1	3	1	2	1	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:160972244C>T	uc003lys.1	-	4	444	c.226G>A	c.(226-228)GAA>AAA	p.E76K	GABRB2_uc011deh.1_5'UTR|GABRB2_uc003lyr.1_Missense_Mutation_p.E76K|GABRB2_uc003lyt.1_Missense_Mutation_p.E76K|GABRB2_uc010jiu.1_Missense_Mutation_p.E13K|GABRB2_uc011dei.1_Missense_Mutation_p.E76K	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	76	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATATTGACTTCAGAAACCATA	0.478													6	15					0	0	0	0	T	160972244	T	T	160972244	3	4	303	1	0	0	0	0	1	0	0	0	6201	835	29	2	1344	2	GABRB2	5	160972244	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6578770	160972244	19943016	228	55755											
CCDC99	54908	broad.mit.edu	37	chr5	169028395	169028395	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcgggggagaagtttatcGattaccgcctcagaaagagg	11	9	13	8	3	2	3	1	0	1	3	4	5	2	3	2	3	1	1	2	3	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:169028395G>A	uc003mae.3	+	11	1715	c.1436G>A	c.(1435-1437)CGA>CAA	p.R479Q	CCDC99_uc010jjj.2_Missense_Mutation_p.R408Q|CCDC99_uc011deq.1_Missense_Mutation_p.R296Q|CCDC99_uc010jjk.2_Missense_Mutation_p.R205Q	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	479					cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAAGTTTATCGATTACCGCCT	0.448													16	37					0	0	0	0	A	169028395	A	A	169028395	3	1	303	1	0	0	0	0	1	0	0	0	2889	1058	37	1	1474	1	CCDC99	5	169028395	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	8056151	169028395	11886865	229	55756											
DOCK2	1794	broad.mit.edu	37	chr5	169125439	169125439	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgaagaaaagcagcacttCattccttttcacccgtaaga	14	10	7	10	1	2	3	2	1	0	2	3	4	3	3	2	0	2	3	2	0	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:169125439C>T	uc003maf.2	+	11	1121	c.1041C>T	c.(1039-1041)TTC>TTT	p.F347F	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	347					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCAGCACTTCATTCCTTTTC	0.418													8	28					0	0	0	0	T	169125439	T	T	169125439	2	4	303	1	0	0	0	0	0	0	0	1	4709	825	29	2		2	DOCK2	5	169125439	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	97044	169125439	11789821	230	55757											
HMP19	51617	broad.mit.edu	37	chr5	173473844	173473844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaccgtccctctcatcaCtcccttggaggttaatcact	8	11	6	16	1	3	1	3	0	1	1	6	2	5	2	4	2	0	1	4	2	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:173473844C>T	uc003mcx.2	+	2	231	c.86C>T	c.(85-87)ACT>ATT	p.T29I		NM_015980	NP_057064	Q9Y328	NSG2_HUMAN	HMP19 protein	29	Cytoplasmic (Potential).				dopamine receptor signaling pathway	cytoplasmic vesicle membrane|Golgi cisterna membrane|integral to membrane|multivesicular body membrane	dopamine receptor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00925)|all_lung(126;0.0148)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCTCTCATCACTCCCTTGGAG	0.532													49	128					0	0	0	0	T	173473844	T	T	173473844	3	4	303	1	0	0	0	0	1	0	0	0	7284	565	20	4	88	4	HMP19	5	173473844	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4348405	173473844	7441416	231	55758											
UNC5A	90249	broad.mit.edu	37	chr5	176306886	176306886	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgtcggaggctgagtgctGaggccggccaggcccgacac	7	5	17	12	3	0	2	0	2	0	0	1	4	0	3	3	5	1	2	3	5	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:176306886G>A	uc003mey.2	+	15	2720	c.2528G>A	c.(2527-2529)TGA>TAA	p.*843*		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	843					apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTGAGTGCTGAGGCCGGCCA	0.672													9	15					0	0	0	0	A	176306886	A	A	176306886	2	1	303	1	0	0	0	0	0	0	0	1	17059	1285	45	2		2	UNC5A	5	176306886	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2833042	176306886	4608374	232	55759											
HK3	3101	broad.mit.edu	37	chr5	176314714	176314714	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	acatcgcattccggggccagGagcatcactgtcccctgcag	8	7	11	15	2	1	0	1	0	0	0	4	1	3	1	4	3	2	3	4	3	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:176314714G>C	uc003mfa.2	-	11	1430	c.1338C>G	c.(1336-1338)CTC>CTG	p.L446L	HK3_uc003mez.2_Silent_p.L2L	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	446	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCGGGGCCAGGAGCATCACTG	0.642													10	45					0	0	0	0	C	176314714	C	C	176314714	2	2	303	1	0	0	0	0	0	0	0	1	7231	1161	41	2		2	HK3	5	176314714	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7828	176314714	4600546	233	55760											
LMAN2	10960	broad.mit.edu	37	chr5	176764408	176764408	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagccaggaaggtgtcgtGatcgcggttgcggaagtcag	9	7	16	9	4	1	1	1	1	0	0	3	3	1	3	1	4	2	1	1	4	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:176764408G>A	uc003mge.2	-	5	868	c.631C>T	c.(631-633)CAC>TAC	p.H211Y	LMAN2_uc003mgd.2_Missense_Mutation_p.H211Y	NM_006816	NP_006807	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2 precursor	211	Lumenal (Potential).|L-type lectin-like.				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGGTGTCGTGATCGCGGTTG	0.667													8	34					0	0	0	0	A	176764408	A	A	176764408	3	1	303	1	0	0	0	0	1	0	0	0	8880	1290	45	2	455	2	LMAN2	5	176764408	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	449694	176764408	4150852	234	55761											
SLC34A1	6569	broad.mit.edu	37	chr5	176823825	176823825	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccagagcagttctgtgttCacctcggccatcaccccact	7	10	8	16	1	3	1	2	0	1	1	5	1	4	1	5	1	1	3	5	1	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:176823825C>G	uc003mgk.3	+	11	1367	c.1266C>G	c.(1264-1266)TTC>TTG	p.F422L		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	422	Helical; Name=M5; (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTCTGTGTTCACCTCGGCCA	0.632													16	61					0	0	0	0	G	176823825	G	G	176823825	3	3	303	1	0	0	0	0	1	0	0	0	14631	825	29	2	1395	2	SLC34A1	5	176823825	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	59417	176823825	4091435	235	55762											
GFPT2	9945	broad.mit.edu	37	chr5	179740938	179740938	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcggtccttacagtagcgcaGcgccaggagggtgtccgcgg	6	6	17	12	5	0	0	0	0	0	0	2	1	2	1	3	4	3	2	3	4	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr5:179740938G>A	uc003mlw.1	-	14	1398	c.1300C>T	c.(1300-1302)CTG>TTG	p.L434L		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	434	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CAGTAGCGCAGCGCCAGGAGG	0.706													4	12					0	0	0	0	A	179740938	A	A	179740938	2	1	303	1	0	0	0	0	0	0	0	1	6383	962	34	4		4	GFPT2	5	179740938	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2917113	179740938	1174322	236	55763											
FOXQ1	94234	broad.mit.edu	37	chr6	1313540	1313540	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ggatgctcaaccccaacagcGagtacaccttcgccgacggg	10	5	11	15	4	1	0	1	0	0	0	2	3	1	1	4	2	5	2	4	2	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:1313540G>C	uc003mtl.3	+	1	866	c.601G>C	c.(601-603)GAG>CAG	p.E201Q		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	201	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		CCCCAACAGCGAGTACACCTT	0.502													11	20					0	0	0	0	C	1313540	C	C	1313540	3	2	303	1	0	0	0	0	1	0	0	0	6064	1059	37	3	603	3	FOXQ1	6	1313540	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08		1313540	169801527	237	55764											
DSP	1832	broad.mit.edu	37	chr6	7569567	7569567	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccactggccgtggacctctCttgcaagtaagtcatccaag	9	9	9	14	1	2	0	1	0	1	0	4	1	3	1	4	2	1	2	4	2	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:7569567C>T	uc003mxp.1	+	12	1847	c.1568C>T	c.(1567-1569)TCT>TTT	p.S523F	DSP_uc003mxq.1_Missense_Mutation_p.S523F	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	523	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GTGGACCTCTCTTGCAAGTAA	0.572													17	45					0	0	0	0	T	7569567	T	T	7569567	3	4	303	1	0	0	0	0	1	0	0	0	4803	913	32	2	1614	2	DSP	6	7569567	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6256027	7569567	163545500	238	55765											
DSP	1832	broad.mit.edu	37	chr6	7574983	7574983	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctcactgaggaggaaactgtCtgcctggacctggataaagt	11	9	12	9	0	2	1	1	1	1	0	2	5	2	5	2	4	2	0	2	4	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:7574983C>G	uc003mxp.1	+	17	2670	c.2391C>G	c.(2389-2391)GTC>GTG	p.V797V	DSP_uc003mxq.1_Silent_p.V797V	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	797	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGGAAACTGTCTGCCTGGACC	0.458													18	44					0	0	0	0	G	7574983	G	G	7574983	2	3	303	1	0	0	0	0	0	0	0	1	4803	900	32	2		2	DSP	6	7574983	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5416	7574983	163540084	239	55766											
DSP	1832	broad.mit.edu	37	chr6	7583931	7583931	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acagtgtctttttgccaaaaGatgtcgccttggcccggggg	7	11	13	10	2	1	1	0	0	1	1	2	1	1	1	3	3	1	0	3	3	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:7583931G>C	uc003mxp.1	+	24	6715	c.6436G>C	c.(6436-6438)GAT>CAT	p.D2146H	DSP_uc003mxq.1_Missense_Mutation_p.D1547H	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2146	Plectin 4.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TTTGCCAAAAGATGTCGCCTT	0.468													9	34					0	0	0	0	C	7583931	C	C	7583931	3	2	303	1	0	0	0	0	1	0	0	0	4803	942	33	2	6530	2	DSP	6	7583931	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	8948	7583931	163531136	240	55767											
ATXN1	6310	broad.mit.edu	37	chr6	16306676	16306676	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cttctccagtttgcggctctCtggcgccgaccacctcctct	3	12	8	18	3	3	0	0	0	3	0	6	1	4	0	5	2	1	2	5	2	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:16306676C>T	uc003nbt.2	-	9	3303	c.2332G>A	c.(2332-2334)GAG>AAG	p.E778K	ATXN1_uc010jpi.2_Missense_Mutation_p.E778K|ATXN1_uc010jpj.1_RNA	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	778	Interaction with USP7.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				TTGCGGCTCTCTGGCGCCGAC	0.532													13	39					0	0	0	0	T	16306676	T	T	16306676	3	4	303	1	0	0	0	0	1	0	0	0	1211	922	32	2	119	2	ATXN1	6	16306676	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	8722745	16306676	154808391	241	55768											
C6orf62	81688	broad.mit.edu	37	chr6	24718801	24718801	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acaaaggcaatatacatcttGaagtcaaactggtcagctag	16	9	8	8	0	3	1	2	1	1	0	3	1	3	1	0	2	3	2	0	2	7	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:24718801G>A	uc003nel.2	-	1	603	c.96C>T	c.(94-96)TTC>TTT	p.F32F		NM_030939	NP_112201	Q9GZU0	CF062_HUMAN	hypothetical protein LOC81688	32						intracellular					0						TATACATCTTGAAGTCAAACT	0.358													9	27					0	0	0	0	A	24718801	A	A	24718801	2	1	303	1	0	0	0	0	0	0	0	1	2378	1281	45	2		2	C6orf62	6	24718801	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	8412125	24718801	146396266	242	55769											
HIST1H1A	3024	broad.mit.edu	37	chr6	26017361	26017361	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtttggcagtctttggcttCgtcaccctagccttggccgc	3	13	12	13	2	2	0	1	0	1	0	3	0	2	0	3	4	1	3	3	4	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:26017361C>A	uc003nfo.2	-	1	680	c.600G>T	c.(598-600)ACG>ACT	p.T200T		NM_005325	NP_005316	Q02539	H11_HUMAN	histone cluster 1, H1a	200					nucleosome assembly|spermatogenesis	nucleosome|nucleus	DNA binding			ovary(2)	2						TCTTTGGCTTCGTCACCCTAG	0.448													21	43					3.7963e-18	3.96804e-18	1	0	A	26017361	A	A	26017361	2	1	303	1	0	0	0	0	0	0	0	1	7161	871	31	3		3	HIST1H1A	6	26017361	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1298560	26017361	145097706	243	55770											
ZKSCAN3	80317	broad.mit.edu	37	chr6	28333766	28333766	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cctttaggcgaagttcacatCtcctgagacatcagaggatc	11	10	9	11	1	3	2	2	1	1	2	5	5	3	3	2	2	0	1	2	2	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:28333766C>T	uc003nle.3	+	6	1537	c.1321C>T	c.(1321-1323)CTC>TTC	p.L441F	ZKSCAN3_uc010jrc.2_Missense_Mutation_p.L441F|ZKSCAN3_uc003nlf.3_Missense_Mutation_p.L293F|uc010jrd.2_5'Flank	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	441	C2H2-type 5.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						AAGTTCACATCTCCTGAGACA	0.498													13	23					0	0	0	0	T	28333766	T	T	28333766	3	4	303	1	0	0	0	0	1	0	0	0	17755	913	32	2	1339	2	ZKSCAN3	6	28333766	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2316405	28333766	142781301	244	55771											
SCAND3	114821	broad.mit.edu	37	chr6	28542879	28542879	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacaagttcttcagttagctGagaatgggacaagcccagtt	13	10	10	8	0	2	1	1	1	1	1	2	3	2	2	1	1	3	4	1	1	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:28542879G>A	uc003nlo.2	-	3	2221	c.1603C>T	c.(1603-1605)CAG>TAG	p.Q535*		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	535					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCAGTTAGCTGAGAATGGGAC	0.408													11	48					0	0	0	0	A	28542879	A	A	28542879	4	1	303	1	0	0	0	0	0	1	0	0	13941	1299	45	2	2382	2	SCAND3	6	28542879	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	209113	28542879	142572188	245	55772											
OR10C1	442194	broad.mit.edu	37	chr6	29408428	29408428	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctgcccctttggcctCatcctgggctcctacgggcg	3	11	10	17	2	2	0	1	0	1	0	5	0	5	0	6	3	2	1	6	3	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:29408428C>T	uc011dlp.1	+	1	636	c.636C>T	c.(634-636)CTC>CTT	p.L212L	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTTTGGCCTCATCCTGGGCT	0.587													45	136					0	0	0	0	T	29408428	T	T	29408428	2	4	303	1	0	0	0	0	0	0	0	1	10952	813	29	2		2	OR10C1	6	29408428	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	865549	29408428	141706639	246	55773											
HLA-A	3105	broad.mit.edu	37	chr6	29911304	29911304	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacctggagaacgggaaggaGacgctgcagcgcacgggtac	11	4	16	10	4	0	2	0	0	0	2	0	5	0	3	1	4	5	4	1	4	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:29911304G>A	uc003nol.2	+	3	603	c.603G>A	c.(601-603)GAG>GAA	p.E201E	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc010jrq.2_Silent_p.E80E|HLA-A_uc003nok.2_Silent_p.E80E|HLA-A_uc003non.2_Silent_p.E201E|HLA-A_uc003noo.2_Silent_p.E201E|HLA-A_uc010jrr.2_Silent_p.E201E|HLA-A_uc003nom.2_Silent_p.E80E|HLA-A_uc010klp.2_Silent_p.E173E|HLA-A_uc011dmc.1_Silent_p.E80E|HLA-A_uc011dmd.1_Silent_p.E80E	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	201	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						ACGGGAAGGAGACGCTGCAGC	0.667									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			21	24					0	0	0	0	A	29911304	A	A	29911304	2	1	303	1	0	0	0	0	0	0	0	1	7234	933	33	2		2	HLA-A	6	29911304	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	502876	29911304	141203763	247	55774											
DDR1	780	broad.mit.edu	37	chr6	30863240	30863240	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccacttacgcccgtccccctCgaggcccgggcccccccaca	5	4	8	24	4	0	0	0	0	0	0	2	1	1	0	8	2	1	0	8	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:30863240C>T	uc003nrr.2	+	13	1832	c.1573C>T	c.(1573-1575)CGA>TGA	p.R525*	DDR1_uc010jse.2_Intron|DDR1_uc003nrq.2_Intron|DDR1_uc003nrs.2_Nonsense_Mutation_p.R525*|DDR1_uc003nrt.2_Intron|DDR1_uc011dms.1_Intron|DDR1_uc003nru.2_Intron|DDR1_uc003nrv.2_Nonsense_Mutation_p.R525*|DDR1_uc003nrw.1_Silent_p.L296L|DDR1_uc003nry.1_Intron|DDR1_uc003nrx.1_Intron|DDR1_uc003nrz.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	525	Gly/Pro-rich.|Cytoplasmic (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	CCGTCCCCCTCGAGGCCCGGG	0.677													68	200					0	0	0	0	T	30863240	T	T	30863240	4	4	303	1	0	0	0	0	0	1	0	0	4353	876	31	1	1615	1	DDR1	6	30863240	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	951936	30863240	140251827	248	55775											
BAT2	7916	broad.mit.edu	37	chr6	31595626	31595626	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacgaaagcagtcgtcatctGagatttccctggcagtggag	10	9	13	9	2	2	1	1	1	1	1	4	5	3	2	1	2	1	2	1	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:31595626G>A	uc003nvb.3	+	12	1624	c.1375G>A	c.(1375-1377)GAG>AAG	p.E459K	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Missense_Mutation_p.E459K	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	459	4 X 57 AA type A repeats.|2 X type B repeats.					cytoplasm|nucleus	protein binding				0						GTCGTCATCTGAGATTTCCCT	0.627													21	62					0	0	0	0	A	31595626	A	A	31595626	3	1	303	1	0	0	0	0	1	0	0	0	1321	1291	45	2	1417	2	BAT2	6	31595626	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	732386	31595626	139519441	249	55776											
SLC44A4	80736	broad.mit.edu	37	chr6	31833471	31833471	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgactccagactcacctctGagcttgtggtcaatatactc	9	11	7	14	1	3	2	2	1	1	1	5	3	4	2	3	1	2	1	3	1	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:31833471G>A	uc010jti.2	-	15	1644	c.1578C>T	c.(1576-1578)CTC>CTT	p.L526L	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	526	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	ACTCACCTCTGAGCTTGTGGT	0.567													56	128					0	0	0	0	A	31833471	A	A	31833471	2	1	303	1	0	0	0	0	0	0	0	1	14702	1277	45	2		2	SLC44A4	6	31833471	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	237845	31833471	139281596	250	55777											
EHMT2	10919	broad.mit.edu	37	chr6	31856205	31856205	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catgcgggcgcggtgggtctCacagagcaccatcagggcca	8	5	15	13	3	2	1	2	0	1	1	3	1	2	1	2	4	2	1	2	4	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:31856205C>G	uc003nxz.1	-	12	1454	c.1444G>C	c.(1444-1446)GAG>CAG	p.E482Q	EHMT2_uc003nxy.1_Missense_Mutation_p.E273Q|EHMT2_uc011don.1_Missense_Mutation_p.E505Q|EHMT2_uc003nya.1_Missense_Mutation_p.E448Q	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	482					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CGGTGGGTCTCACAGAGCACC	0.652													8	23					0	0	0	0	G	31856205	G	G	31856205	3	3	303	1	0	0	0	0	1	0	0	0	5006	835	29	2	2256	2	EHMT2	6	31856205	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	22734	31856205	139258862	251	55778											
NOTCH4	4855	broad.mit.edu	37	chr6	32166501	32166501	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcaacttctgcctttggcttCagtgccctggaaaggaatgg	8	12	11	10	0	3	0	2	0	1	0	3	2	3	2	2	4	3	1	2	4	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:32166501C>T	uc003obb.2	-	25	4681	c.4542G>A	c.(4540-4542)CTG>CTA	p.L1514L	NOTCH4_uc011dpt.1_5'Flank|NOTCH4_uc003oba.2_Silent_p.L177L|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_5'Flank	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1514	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CCTTTGGCTTCAGTGCCCTGG	0.557													9	19					0	0	0	0	T	32166501	T	T	32166501	2	4	303	1	0	0	0	0	0	0	0	1	10605	813	29	2		2	NOTCH4	6	32166501	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	310296	32166501	138948566	252	55779											
WDR46	9277	broad.mit.edu	37	chr6	33256651	33256651	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgggacctgaggcttcttaGagatccgagacttctttaag	9	12	11	9	2	2	3	0	1	2	2	4	6	3	4	2	2	0	1	2	2	2	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:33256651G>A	uc003ods.2	-	2	253	c.209C>T	c.(208-210)TCT>TTT	p.S70F	WDR46_uc011dra.1_Intron|WDR46_uc010juo.1_5'Flank|PFDN6_uc003odt.1_5'Flank|PFDN6_uc010jup.1_5'Flank	NM_005452	NP_005443	O15213	WDR46_HUMAN	WD repeat domain 46 isoform 1	70											0						AGGCTTCTTAGAGATCCGAGA	0.577													12	24					0	0	0	0	A	33256651	A	A	33256651	3	1	303	1	0	0	0	0	1	0	0	0	17367	942	33	2	1679	2	WDR46	6	33256651	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1090150	33256651	137858416	253	55780											
STK38	11329	broad.mit.edu	37	chr6	36508036	36508036	+	Translation_Start_Site	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggagttagaatccacccaGtgtgcactctcctaccctat	9	12	7	13	0	1	1	0	0	1	1	3	2	2	2	4	1	2	2	4	1	4	4	rs6913714	by1000genomes	TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:36508036G>T	uc003omg.2	-	1	532	c.-56C>A	c.(-58--54)CACTG>CAATG		STK38_uc003omh.2_Intron|STK38_uc003omi.2_Intron	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38						intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						aatccacccagtgtgcactct	0.104													5	23					0.000602214	0.000607054	1	0	T	36508036	T	T	36508036	1	4	303	1	0	0	0	0	0	0	0	0	15369	1044	36	4		4	STK38	6	36508036	Translation_Start_Site	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3251385	36508036	134607031	254	55781											
DNAH8	1769	broad.mit.edu	37	chr6	38759406	38759406	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtgttgatttctctgcctGaaagtggtgctaccaaagta	9	14	10	8	0	1	2	0	2	1	0	2	2	1	2	2	1	3	3	2	1	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:38759406G>C	uc003ooe.1	+	19	2806	c.2206G>C	c.(2206-2208)GAA>CAA	p.E736Q		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTCTCTGCCTGAAAGTGGTGC	0.343													9	26					0	0	0	0	C	38759406	C	C	38759406	3	2	303	1	0	0	0	0	1	0	0	0	4629	1291	45	2	2272	2	DNAH8	6	38759406	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2251370	38759406	132355661	255	55782											
DNAH8	1769	broad.mit.edu	37	chr6	38816451	38816451	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctccatttaaaaaaaatatCcagaattgggtgtataaatt	17	13	6	5	0	0	1	0	0	0	1	2	1	2	1	2	1	0	2	2	1	9	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:38816451C>T	uc003ooe.1	+	35	5022	c.4422C>T	c.(4420-4422)ATC>ATT	p.I1474I		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAAAAAATATCCAGAATTGGG	0.348													5	13					0	0	0	0	T	38816451	T	T	38816451	2	4	303	1	0	0	0	0	0	0	0	1	4629	845	30	2		2	DNAH8	6	38816451	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	57045	38816451	132298616	256	55783											
MRPL2	51069	broad.mit.edu	37	chr6	43025831	43025831	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctcggcccccagacttcctCatcttcactggtgtaatggt	6	13	8	14	1	4	1	2	0	2	1	6	1	5	1	3	3	0	1	3	3	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:43025831C>T	uc003ots.1	-	2	360	c.237G>A	c.(235-237)ATG>ATA	p.M79I	KLC4_uc003otr.1_Intron|MRPL2_uc011dvc.1_Missense_Mutation_p.M79I|MRPL2_uc010jyi.2_3'UTR|MRPL2_uc003ott.3_Missense_Mutation_p.M79I|KLC4_uc011dvd.1_5'Flank|KLC4_uc003otu.2_5'Flank|KLC4_uc003otv.1_5'Flank|KLC4_uc003otw.1_5'Flank|KLC4_uc003otx.1_5'Flank|KLC4_uc003oty.1_5'Flank|KLC4_uc003otz.1_5'Flank	NM_015950	NP_057034	Q5T653	RM02_HUMAN	mitochondrial ribosomal protein L2 precursor	79					translation	mitochondrion|ribosome	structural constituent of ribosome				0		Ovarian(999;0.0014)	Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00708)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)	BRCA - Breast invasive adenocarcinoma(397;0.0026)		CAGACTTCCTCATCTTCACTG	0.488													28	62					0	0	0	0	T	43025831	T	T	43025831	3	4	303	1	0	0	0	0	1	0	0	0	9838	826	29	2	704	2	MRPL2	6	43025831	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4209380	43025831	128089236	257	55784											
GSTA3	2940	broad.mit.edu	37	chr6	52767200	52767200	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatttgctggcaatgtagttGagaatggctctggtctgtac	8	15	12	6	0	2	1	0	1	2	1	2	2	2	1	0	3	2	6	0	3	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:52767200G>A	uc003pbb.2	-	4	295	c.216C>T	c.(214-216)CTC>CTT	p.L72L	GSTA3_uc010jzq.2_Silent_p.L16L	NM_000847	NP_000838	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	72	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity				0	Lung NSC(77;0.0912)				Glutathione(DB00143)	CAATGTAGTTGAGAATGGCTC	0.423													53	141					0	0	0	0	A	52767200	A	A	52767200	2	1	303	1	0	0	0	0	0	0	0	1	6871	1277	45	2		2	GSTA3	6	52767200	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	9741369	52767200	118347867	258	55785											
PHF3	23469	broad.mit.edu	37	chr6	64404585	64404585	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tacctcggagatcctcagaaGaaaaaagtgaaaaaataccg	19	6	8	8	2	1	4	1	1	0	3	3	5	2	4	3	1	2	0	3	1	9	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:64404585G>C	uc003pep.1	+	5	2637	c.2611G>C	c.(2611-2613)GAA>CAA	p.E871Q	PHF3_uc010kaf.1_Missense_Mutation_p.E871Q|PHF3_uc003pem.2_Missense_Mutation_p.E824Q|PHF3_uc010kag.1_Missense_Mutation_p.E783Q|PHF3_uc010kah.1_Missense_Mutation_p.E685Q|PHF3_uc003pen.2_Missense_Mutation_p.E783Q|PHF3_uc011dxs.1_Missense_Mutation_p.E140Q	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	871					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			ATCCTCAGAAGAAAAAAGTGA	0.358													34	48					0	0	0	0	C	64404585	C	C	64404585	3	2	303	1	0	0	0	0	1	0	0	0	11891	943	33	2	2629	2	PHF3	6	64404585	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	11637385	64404585	106710482	259	55786											
OGFRL1	79627	broad.mit.edu	37	chr6	72003263	72003263	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagatatccgatatcaaaatGacttgagcaatcttcgtttt	14	14	6	7	2	2	3	1	2	1	1	4	4	3	3	1	0	1	2	1	0	6	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:72003263G>A	uc003pfx.1	+	3	512	c.349G>A	c.(349-351)GAC>AAC	p.D117N		NM_024576	NP_078852	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	117						membrane	receptor activity				0						ATATCAAAATGACTTGAGCAA	0.323													6	15					0	0	0	0	A	72003263	A	A	72003263	3	1	303	1	0	0	0	0	1	0	0	0	10898	1290	45	2	359	2	OGFRL1	6	72003263	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7598678	72003263	99111804	260	55787											
KCNQ5	56479	broad.mit.edu	37	chr6	73900384	73900384	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcattgaacaatattctgctGgtcatctggacatgttgtgt	9	16	9	7	0	4	1	2	1	2	0	4	2	4	2	0	2	2	2	0	2	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:73900384G>C	uc003pgk.2	+	12	2013	c.1666G>C	c.(1666-1668)GGT>CGT	p.G556R	KCNQ5_uc011dyh.1_Missense_Mutation_p.G575R|KCNQ5_uc011dyi.1_Missense_Mutation_p.G566R|KCNQ5_uc010kat.2_Missense_Mutation_p.G547R|KCNQ5_uc011dyj.1_Missense_Mutation_p.G446R|KCNQ5_uc011dyk.1_Missense_Mutation_p.G306R	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	556					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		ATATTCTGCTGGTCATCTGGA	0.353													11	38					0	0	0	0	C	73900384	C	C	73900384	3	2	303	1	0	0	0	0	1	0	0	0	8125	1348	47	4	1773	4	KCNQ5	6	73900384	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1897121	73900384	97214683	261	55788											
PHIP	55023	broad.mit.edu	37	chr6	79770451	79770451	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgtactccaggaacactttGaggaatttcttgttcaagaa	12	14	8	7	0	2	2	1	1	1	1	3	4	3	4	1	2	2	2	1	2	5	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:79770451G>C	uc003pir.2	-	5	500	c.274C>G	c.(274-276)CAA>GAA	p.Q92E	PHIP_uc011dyp.1_Missense_Mutation_p.Q92E	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	92					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		GGAACACTTTGAGGAATTTCT	0.353													13	47					0	0	0	0	C	79770451	C	C	79770451	3	2	303	1	0	0	0	0	1	0	0	0	11897	1299	45	2	5335	2	PHIP	6	79770451	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5870067	79770451	91344616	262	55789											
MRAP2	112609	broad.mit.edu	37	chr6	84765060	84765060	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtccgcccagaggttaatttCtaacagaacctcccagcaat	12	9	7	13	1	1	2	0	0	1	2	3	2	3	2	4	1	3	2	4	1	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:84765060C>G	uc003pkg.3	+	2	213	c.23C>G	c.(22-24)TCT>TGT	p.S8C	MRAP2_uc010kbo.2_5'UTR	NM_138409	NP_612418	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	8					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			skin(2)	2						AGGTTAATTTCTAACAGAACC	0.433													16	33					0	0	0	0	G	84765060	G	G	84765060	3	3	303	1	0	0	0	0	1	0	0	0	9807	913	32	2	25	2	MRAP2	6	84765060	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4994609	84765060	86350007	263	55790											
CNR1	1268	broad.mit.edu	37	chr6	88853580	88853580	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agggaggcatcaggctcacaGagcctcggcagacgtgtctg	9	6	15	11	2	3	2	2	0	1	2	4	3	3	3	1	4	1	3	1	4	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:88853580G>C	uc011dzq.1	-	2	4977	c.1414C>G	c.(1414-1416)CTG>GTG	p.L472V	CNR1_uc010kbz.2_Missense_Mutation_p.L472V|CNR1_uc011dzr.1_Missense_Mutation_p.L472V|CNR1_uc011dzs.1_Missense_Mutation_p.L472V|CNR1_uc003pmq.3_Missense_Mutation_p.L472V|CNR1_uc011dzt.1_Missense_Mutation_p.L472V|CNR1_uc010kca.2_Missense_Mutation_p.L439V	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	472	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	CAGGCTCACAGAGCCTCGGCA	0.463													53	147					0	0	0	0	C	88853580	C	C	88853580	3	2	303	1	0	0	0	0	1	0	0	0	3646	933	33	2	8	2	CNR1	6	88853580	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4088520	88853580	82261487	264	55791											
MDN1	23195	broad.mit.edu	37	chr6	90364054	90364054	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgttctttgctggccacatCtgtcaacaaagcacgcaccc	9	10	7	15	1	3	0	1	0	2	0	3	0	3	0	2	1	3	4	2	1	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:90364054C>T	uc003pnn.1	-	93	15607	c.15491_splice	c.e93-1	p.D5164_splice		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CTGGCCACATCTGTCAACAAA	0.443													32	95					0	0	0	0	T	90364054	T	T	90364054	5	4	303	1	0	0	0	0	0	0	1	0	9468	927	32	2	1340	2	MDN1	6	90364054	Splice_Site	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1510474	90364054	80751013	265	55792											
MDN1	23195	broad.mit.edu	37	chr6	90371153	90371153	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtttctgaaagacgcaccttCtccttcttcattgtcggtgt	6	16	8	11	2	4	2	1	1	3	1	6	2	4	2	2	1	0	2	2	1	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:90371153C>T	uc003pnn.1	-	88	14826	c.14710G>A	c.(14710-14712)GAA>AAA	p.E4904K		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4904					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GACGCACCTTCTCCTTCTTCA	0.468													22	68					0	0	0	0	T	90371153	T	T	90371153	3	4	303	1	0	0	0	0	1	0	0	0	9468	922	32	2	2140	2	MDN1	6	90371153	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	7099	90371153	80743914	266	55793											
PPIL6	285755	broad.mit.edu	37	chr6	109740402	109740403	+	Missense_Mutation	DNP	GA	AC	AC																															atacataccttcaaatgttgGaccataaatcgactctccat																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:109740402_109740403GA>AC	uc003ptg.3	-	6	729_730	c.675_676TC>GT	c.(673-678)GGTCCA>GGGTCA	p.P226S	PPIL6_uc010kdo.2_Missense_Mutation_p.P194S|PPIL6_uc010kdp.2_Missense_Mutation_p.P226S	NM_173672	NP_775943	Q8IXY8	PPIL6_HUMAN	peptidylprolyl isomerase-like 6 isoform 1	226	PPIase cyclophilin-type.				protein folding		peptidyl-prolyl cis-trans isomerase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.00684)|BRCA - Breast invasive adenocarcinoma(108;0.00889)|all cancers(137;0.0106)|OV - Ovarian serous cystadenocarcinoma(136;0.0259)		TCAAATGTTGGACCATAAATCG	0.287													25	80					0	0	0	0	AC	109740403	AC	AC	109740402	3	1	303	1	0	0	0	0	1	0	0	0	12391	1174	41	2	353	2	PPIL6	6	109740402	Missense_Mutation	DNP	GA	TCGA-HL-7533-01A-11D-2229-08	19369249	109740402	61374665	267	55794											
REV3L	5980	broad.mit.edu	37	chr6	111678260	111678260	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaaaaagtgccttctcatCagcagcataggtgacttcga	13	10	9	9	1	2	2	2	2	1	0	4	3	2	2	1	1	3	2	1	1	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:111678260C>G	uc003puy.3	-	18	7464	c.7141G>C	c.(7141-7143)GAT>CAT	p.D2381H	REV3L_uc003pux.3_Missense_Mutation_p.D2303H|REV3L_uc003puz.3_Missense_Mutation_p.D2303H|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2381					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GCCTTCTCATCAGCAGCATAG	0.303								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					13	68					0	0	0	0	G	111678260	G	G	111678260	3	3	303	1	0	0	0	0	1	0	0	0	13305	826	29	2	2311	2	REV3L	6	111678260	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1937858	111678260	59436807	268	55795											
FYN	2534	broad.mit.edu	37	chr6	112035584	112035584	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgaaatttttctcctttgtGaaaactcaggtcatcttctg	9	18	6	8	0	5	2	2	2	3	0	6	2	5	2	1	1	1	0	1	1	3	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:112035584G>A	uc003pvj.2	-	4	650	c.310C>T	c.(310-312)CAC>TAC	p.H104Y	FYN_uc003pvi.2_Missense_Mutation_p.H104Y|FYN_uc003pvk.2_Missense_Mutation_p.H104Y|FYN_uc003pvh.2_Missense_Mutation_p.H104Y	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	104	SH3.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TCTCCTTTGTGAAAACTCAGG	0.428													9	32					0	0	0	0	A	112035584	A	A	112035584	3	1	303	1	0	0	0	0	1	0	0	0	6160	1290	45	2	1503	2	FYN	6	112035584	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	357324	112035584	59079483	269	55796											
C6orf225	619208	broad.mit.edu	37	chr6	112420550	112420550	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaggaggagattcttcaattGagctggaacctgggctgagc	11	9	14	7	0	2	3	1	2	1	1	2	6	2	5	1	4	3	2	1	4	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:112420550G>C	uc003pvs.2	+	3	489	c.64G>C	c.(64-66)GAG>CAG	p.E22Q		NM_001033564	NP_001028736	Q4G0N7	CF225_HUMAN	hypothetical protein LOC619208	22											0						TTCTTCAATTGAGCTGGAACC	0.448													25	64					0	0	0	0	C	112420550	C	C	112420550	3	2	303	1	0	0	0	0	1	0	0	0	2368	1291	45	2	66	2	C6orf225	6	112420550	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	384966	112420550	58694517	270	55797											
VGLL2	245806	broad.mit.edu	37	chr6	117589564	117589564	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acatcagctccgtggtggatGaacatttcagcagggccctg	9	9	12	11	1	2	1	2	1	0	0	3	2	3	2	2	3	3	2	2	3	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:117589564G>A	uc003pxn.2	+	2	491	c.301G>A	c.(301-303)GAA>AAA	p.E101K	VGLL2_uc003pxo.2_Missense_Mutation_p.E101K	NM_182645	NP_872586	Q8N8G2	VGLL2_HUMAN	vestigial-like 2 isoform 1	101					transcription, DNA-dependent	nucleus				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(226;0.0254)|all cancers(137;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.0757)		CGTGGTGGATGAACATTTCAG	0.582													13	33					0	0	0	0	A	117589564	A	A	117589564	3	1	303	1	0	0	0	0	1	0	0	0	17227	1291	45	2	307	2	VGLL2	6	117589564	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5169014	117589564	53525503	271	55798											
THEMIS	387357	broad.mit.edu	37	chr6	128150858	128150858	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attaaatgagtgagtttgatGattccttgctactgcacagc	11	14	9	7	0	0	4	0	4	0	0	1	4	1	4	1	0	4	3	1	0	3	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:128150858G>A	uc003qbi.2	-	4	791	c.472C>T	c.(472-474)CAT>TAT	p.H158Y	THEMIS_uc010kfa.2_Missense_Mutation_p.H61Y|THEMIS_uc011ebt.1_Missense_Mutation_p.H158Y|THEMIS_uc010kfb.2_Missense_Mutation_p.H123Y	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	158	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TGAGTTTGATGATTCCTTGCT	0.388													38	84					0	0	0	0	A	128150858	A	A	128150858	3	1	303	1	0	0	0	0	1	0	0	0	15926	1290	45	2	1590	2	THEMIS	6	128150858	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10561294	128150858	42964209	272	55799											
SAMD3	154075	broad.mit.edu	37	chr6	130465700	130465700	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctgaaatcctacttcgttttCcttttctttcaaagaaggaa	11	16	5	9	1	2	2	1	1	1	1	5	3	4	3	2	1	1	1	2	1	5	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:130465700C>T	uc003qbv.2	-	13	1854	c.1528G>A	c.(1528-1530)GAA>AAA	p.E510K	SAMD3_uc003qbx.2_Missense_Mutation_p.E510K|SAMD3_uc003qbw.2_Missense_Mutation_p.E510K	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	510										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		ACTTCGTTTTCCTTTTCTTTC	0.373													12	25					0	0	0	0	T	130465700	T	T	130465700	3	4	303	1	0	0	0	0	1	0	0	0	13885	864	30	2	38	2	SAMD3	6	130465700	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2314842	130465700	40649367	273	55800											
TCF21	6943	broad.mit.edu	37	chr6	134212881	134212881	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttatggtggccgggaaacccGagagtgacctgaaagaagtg	12	7	15	7	2	0	4	0	2	0	2	0	6	0	5	3	3	1	0	3	3	4	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:134212881G>A	uc003qei.3	+	2	757	c.481G>A	c.(481-483)GAG>AAG	p.E161K	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Missense_Mutation_p.E161K	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	161					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		CGGGAAACCCGAGAGTGACCT	0.657													9	42					0	0	0	0	A	134212881	A	A	134212881	3	1	303	1	0	0	0	0	1	0	0	0	15757	1059	37	1	487	1	TCF21	6	134212881	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3747181	134212881	36902186	274	55801											
UTRN	7402	broad.mit.edu	37	chr6	145110403	145110403	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctccaaaggtctcttggaaGaaaaatacagatgtatgtaa	16	11	8	6	0	2	2	0	0	2	2	4	3	2	3	1	2	1	2	1	2	7	4	rs148004522		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:145110403G>A	uc003qkt.2	+	61	9000	c.8908G>A	c.(8908-8910)GAA>AAA	p.E2970K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2970	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TCTCTTGGAAGAAAAATACAG	0.284													22	61					0	0	0	0	A	145110403	A	A	145110403	3	1	303	1	0	0	0	0	1	0	0	0	17171	943	33	2	9150	2	UTRN	6	145110403	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10897522	145110403	26004664	275	55802											
GRM1	2911	broad.mit.edu	37	chr6	146350788	146350788	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccagaatggacggagatgtCatcattggagccctcttctc	9	10	11	11	1	4	2	2	0	2	2	5	5	4	4	2	3	1	0	2	3	1	2	rs143790799		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:146350788C>T	uc010khw.1	+	2	605	c.135C>T	c.(133-135)GTC>GTT	p.V45V	GRM1_uc010khu.1_Silent_p.V45V|GRM1_uc010khv.1_Silent_p.V45V|GRM1_uc003qll.2_Silent_p.V45V|GRM1_uc011edz.1_Silent_p.V45V|GRM1_uc011eea.1_Silent_p.V45V	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	45	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ACGGAGATGTCATCATTGGAG	0.597													14	50					0	0	0	0	T	146350788	T	T	146350788	2	4	303	1	0	0	0	0	0	0	0	1	6835	813	29	2		2	GRM1	6	146350788	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1240385	146350788	24764279	276	55803											
SASH1	23328	broad.mit.edu	37	chr6	148865326	148865326	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgaacctcagaaattgaCaactaagaaactggagggct	15	9	9	8	0	2	4	1	2	1	2	2	5	2	5	1	2	3	1	1	2	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:148865326C>G	uc003qme.1	+	18	3195	c.2720C>G	c.(2719-2721)ACA>AGA	p.T907R	SASH1_uc011eeb.1_Missense_Mutation_p.T668R|SASH1_uc003qmf.1_Missense_Mutation_p.T317R	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	907							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CAGAAATTGACAACTAAGAAA	0.532													32	65					0	0	0	0	G	148865326	G	G	148865326	3	3	303	1	0	0	0	0	1	0	0	0	13913	478	17	4	2790	4	SASH1	6	148865326	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2514538	148865326	22249741	277	55804											
UST	10090	broad.mit.edu	37	chr6	149262512	149262512	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aatcttgtcggagaagcacgGatttaatttggtcacatcag	12	12	10	7	2	3	1	2	0	1	1	4	3	3	2	0	3	1	1	0	3	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:149262512G>C	uc003qmg.2	+	3	685	c.389G>C	c.(388-390)GGA>GCA	p.G130A		NM_005715	NP_005706	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase	130	Lumenal (Potential).				protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			ovary(2)	2		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		GAGAAGCACGGATTTAATTTG	0.433													34	74					0	0	0	0	C	149262512	C	C	149262512	3	2	303	1	0	0	0	0	1	0	0	0	17161	1174	41	2	399	2	UST	6	149262512	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	397186	149262512	21852555	278	55805											
SYNE1	23345	broad.mit.edu	37	chr6	152708396	152708396	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaggacgaacttctctttCagacctggctgtggttgtaa	9	12	11	9	1	2	1	1	0	1	1	3	3	2	2	1	3	2	4	1	3	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:152708396C>T	uc010kiw.2	-	54	8900	c.8298G>A	c.(8296-8298)CTG>CTA	p.L2766L	SYNE1_uc003qot.3_Silent_p.L2773L|SYNE1_uc003qou.3_Silent_p.L2766L|SYNE1_uc010kjb.1_Silent_p.L2749L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2766	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACTTCTCTTTCAGACCTGGCT	0.493										HNSCC(10;0.0054)			33	95					0	0	0	0	T	152708396	T	T	152708396	2	4	303	1	0	0	0	0	0	0	0	1	15511	813	29	2		2	SYNE1	6	152708396	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3445884	152708396	18406671	279	55806											
ARID1B	57492	broad.mit.edu	37	chr6	157522173	157522173	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ccagaacaggcagggccctgGcggccctacacaggcgcccc	8	2	13	18	2	0	1	0	0	0	1	0	1	0	1	5	5	2	1	5	5	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:157522173G>A	uc003qqn.2	+	18	4543	c.4391G>A	c.(4390-4392)GGC>GAC	p.G1464D	ARID1B_uc003qqo.2_Missense_Mutation_p.G1424D|ARID1B_uc003qqp.2_Missense_Mutation_p.G1411D	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1469	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CAGGGCCCTGGCGGCCCTACA	0.597													9	27					0	0	0	0	A	157522173	A	A	157522173	3	1	303	1	0	0	0	0	1	0	0	0	914	1203	42	4	4515	4	ARID1B	6	157522173	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4813777	157522173	13592894	280	55807											
ARID1B	57492	broad.mit.edu	37	chr6	157522462	157522462	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctccttttctgccgtctatGaagatgcagaaggtcatgcc	8	13	9	11	1	4	3	1	1	3	2	5	3	4	3	3	1	3	1	3	1	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:157522462G>C	uc003qqn.2	+	18	4832	c.4680G>C	c.(4678-4680)ATG>ATC	p.M1560I	ARID1B_uc003qqo.2_Missense_Mutation_p.M1520I|ARID1B_uc003qqp.2_Missense_Mutation_p.M1507I	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1565	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TGCCGTCTATGAAGATGCAGA	0.602													23	61					0	0	0	0	C	157522462	C	C	157522462	3	2	303	1	0	0	0	0	1	0	0	0	914	1290	45	2	4804	2	ARID1B	6	157522462	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	289	157522462	13592605	281	55808											
PNLDC1	154197	broad.mit.edu	37	chr6	160239618	160239618	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcccgagtcatcctttcctCagtaccttgacgtgctggct	5	13	9	14	2	2	1	2	1	0	0	4	2	4	1	4	1	3	3	4	1	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:160239618C>G	uc003qsx.1	+	16	1327	c.1156C>G	c.(1156-1158)CAG>GAG	p.Q386E	PNLDC1_uc003qsy.1_Missense_Mutation_p.Q397E	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	386	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		ATCCTTTCCTCAGTACCTTGA	0.577													22	51					0	0	0	0	G	160239618	G	G	160239618	3	3	303	1	0	0	0	0	1	0	0	0	12203	827	29	2	1214	2	PNLDC1	6	160239618	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2717156	160239618	10875449	282	55809											
THBS2	7058	broad.mit.edu	37	chr6	169634894	169634894	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cccccacgcaggccttccctCcgtactgaggctcagggctg	5	7	11	18	2	1	1	1	1	0	0	3	1	3	1	5	3	1	4	5	3	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr6:169634894C>T	uc003qwt.2	-	11	1834	c.1586G>A	c.(1585-1587)GGA>GAA	p.G529E		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	529	TSP type-1 3.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGCCTTCCCTCCGTACTGAGG	0.677													24	60					0	0	0	0	T	169634894	T	T	169634894	3	4	303	1	0	0	0	0	1	0	0	0	15920	855	30	2	1984	2	THBS2	6	169634894	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	9395276	169634894	1480173	283	55810											
SDK1	221935	broad.mit.edu	37	chr7	4089060	4089060	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcctgtggaaccctccgcctCagcagtttatcaatggcatc	8	11	8	14	1	2	0	2	0	0	0	5	1	4	1	4	2	2	3	4	2	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:4089060C>T	uc003smx.2	+	18	2822	c.2683C>T	c.(2683-2685)CAG>TAG	p.Q895*	SDK1_uc010kso.2_Nonsense_Mutation_p.Q171*	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	895	Fibronectin type-III 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCTCCGCCTCAGCAGTTTAT	0.612													22	35					0	0	0	0	T	4089060	T	T	4089060	4	4	303	1	0	0	0	0	0	1	0	0	14033	827	29	2	2753	2	SDK1	7	4089060	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08		4089060	155049603	284	55811											
MACC1	346389	broad.mit.edu	37	chr7	20199825	20199825	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcattattaccacgaagggtGaaagcatccggccaattgtg	12	9	11	9	2	0	1	0	1	0	0	1	2	1	1	3	2	2	2	3	2	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:20199825G>A	uc003sus.3	-	5	468	c.159C>T	c.(157-159)TTC>TTT	p.F53F	MACC1_uc010kug.2_Silent_p.F53F	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	53					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						CACGAAGGGTGAAAGCATCCG	0.398													22	45					0	0	0	0	A	20199825	A	A	20199825	2	1	303	1	0	0	0	0	0	0	0	1	9194	1281	45	2		2	MACC1	7	20199825	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	16110765	20199825	138938838	285	55812											
DNAH11	8701	broad.mit.edu	37	chr7	21721216	21721216	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gctgggagaacttccacctgGagacagacagaagatcatga	14	6	12	9	0	1	6	1	1	0	5	2	8	2	6	2	2	1	1	2	2	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:21721216G>A	uc003svc.2	+	31	5427	c.5396G>A	c.(5395-5397)GGA>GAA	p.G1799E		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1799	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTTCCACCTGGAGACAGACAG	0.383									Kartagener_syndrome				10	32					0	0	0	0	A	21721216	A	A	21721216	3	1	303	1	0	0	0	0	1	0	0	0	4621	1174	41	2	5518	2	DNAH11	7	21721216	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1521391	21721216	137417447	286	55813											
GARS	2617	broad.mit.edu	37	chr7	30651843	30651843	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgagatctcccctcgatCtggactgatcagagtcaggt	11	10	10	10	1	4	3	2	2	2	2	6	6	4	4	2	2	0	0	2	2	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:30651843C>G	uc003tbm.2	+	8	1370	c.1013C>G	c.(1012-1014)TCT>TGT	p.S338C		NM_002047	NP_002038	P41250	SYG_HUMAN	glycyl-tRNA synthetase	338					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)	TCCCCTCGATCTGGACTGATC	0.398													19	27					0	0	0	0	G	30651843	G	G	30651843	3	3	303	1	0	0	0	0	1	0	0	0	6277	913	32	2	1043	2	GARS	7	30651843	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	8930627	30651843	128486820	287	55814											
BMPER	168667	broad.mit.edu	37	chr7	34118702	34118702	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcctgcagcagcacctcaccGtgcgctggaacggctcgcgc	6	5	13	17	5	1	0	1	0	0	0	2	1	1	1	3	2	5	5	3	2	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:34118702G>A	uc011kap.1	+	12	1426	c.1312G>A	c.(1312-1314)GTG>ATG	p.V438M		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	438	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						GCACCTCACCGTGCGCTGGAA	0.657													19	64					0	0	0	0	A	34118702	A	A	34118702	3	1	303	1	0	0	0	0	1	0	0	0	1471	1145	40	1	1358	1	BMPER	7	34118702	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3466859	34118702	125019961	288	55815											
ELMO1	9844	broad.mit.edu	37	chr7	37311478	37311478	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatagtgccattttttatctCattgcggttctggaaaagaa	11	15	9	6	1	2	1	1	0	2	1	3	3	2	2	1	2	2	1	1	2	5	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:37311478C>G	uc003tfk.1	-	5	509	c.202G>C	c.(202-204)GAG>CAG	p.E68Q	ELMO1_uc011kbc.1_5'UTR|ELMO1_uc010kxg.1_Missense_Mutation_p.E68Q	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	68					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						TTTTTTATCTCATTGCGGTTC	0.353													11	39					0	0	0	0	G	37311478	G	G	37311478	3	3	303	1	0	0	0	0	1	0	0	0	5089	835	29	2	2053	2	ELMO1	7	37311478	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3192776	37311478	121827185	289	55816											
TXNDC3	51314	broad.mit.edu	37	chr7	37907333	37907333	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaagagtttgtctcttttatGacaagtggcttaagctatat	11	16	9	5	0	1	2	0	1	1	1	2	3	1	2	0	1	1	3	0	1	6	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:37907333G>A	uc003tfn.2	+	11	1023	c.651G>A	c.(649-651)ATG>ATA	p.M217I		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	217	NDK 1.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TCTCTTTTATGACAAGTGGCT	0.403									Kartagener_syndrome				10	29					0	0	0	0	A	37907333	A	A	37907333	3	1	303	1	0	0	0	0	1	0	0	0	16866	1290	45	2	685	2	TXNDC3	7	37907333	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	595855	37907333	121231330	290	55817											
C7orf57	136288	broad.mit.edu	37	chr7	48080963	48080963	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtcccagtgaagcgctctGagaaggccgtggatgcccca	9	6	13	13	3	1	2	0	2	1	1	2	4	2	3	4	2	2	1	4	2	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:48080963G>A	uc003toh.3	+	3	300	c.88G>A	c.(88-90)GAG>AAG	p.E30K	C7orf57_uc003toi.3_5'UTR	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	30										ovary(1)	1						GAAGCGCTCTGAGAAGGCCGT	0.587													15	51					0	0	0	0	A	48080963	A	A	48080963	3	1	303	1	0	0	0	0	1	0	0	0	2415	1291	45	2	94	2	C7orf57	7	48080963	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10173630	48080963	111057700	291	55818											
C7orf57	136288	broad.mit.edu	37	chr7	48092436	48092436	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccagggcatcagtgttatctCagtccccacgagacctggaa	10	8	10	13	1	2	1	2	0	1	1	4	3	3	2	4	2	0	2	4	2	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:48092436C>G	uc003toh.3	+	7	957	c.745C>G	c.(745-747)CAG>GAG	p.Q249E	C7orf57_uc003toi.3_Missense_Mutation_p.Q107E	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	249										ovary(1)	1						AGTGTTATCTCAGTCCCCACG	0.572													9	31					0	0	0	0	G	48092436	G	G	48092436	3	3	303	1	0	0	0	0	1	0	0	0	2415	827	29	2	767	2	C7orf57	7	48092436	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	11473	48092436	111046227	292	55819											
GRB10	2887	broad.mit.edu	37	chr7	50737553	50737553	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaactgctggtcttcctcctGaaggcgcctggaaggcaggg	8	8	14	11	1	1	1	0	1	1	0	3	2	3	2	3	5	2	2	3	5	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:50737553G>C	uc003tpi.2	-	4	401	c.370C>G	c.(370-372)CAG>GAG	p.Q124E	GRB10_uc003tph.3_Missense_Mutation_p.Q66E|GRB10_uc003tpj.2_Missense_Mutation_p.Q124E|GRB10_uc003tpk.2_Missense_Mutation_p.Q124E|GRB10_uc010kzb.2_Missense_Mutation_p.Q66E|GRB10_uc003tpl.2_Missense_Mutation_p.Q118E|GRB10_uc003tpm.2_Missense_Mutation_p.Q66E|GRB10_uc003tpn.2_Missense_Mutation_p.Q66E	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	124					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					TCTTCCTCCTGAAGGCGCCTG	0.438									Russell-Silver_syndrome				3	7					0	0	0	0	C	50737553	C	C	50737553	3	2	303	1	0	0	0	0	1	0	0	0	6795	1299	45	2	1466	2	GRB10	7	50737553	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2645117	50737553	108401110	293	55820											
ZNF107	51427	broad.mit.edu	37	chr7	64167169	64167169	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagaaaagccctacaaatgtGaagaatgtggcaaagccttt	16	8	10	7	0	0	3	0	1	0	2	0	4	0	3	2	1	3	1	2	1	7	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:64167169G>T	uc003ttd.2	+	7	1273	c.487G>T	c.(487-489)GAA>TAA	p.E163*	ZNF107_uc003tte.2_Nonsense_Mutation_p.E163*	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	163	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CTACAAATGTGAAGAATGTGG	0.378													5	23					3.59834e-05	3.64399e-05	1	0	T	64167169	T	T	64167169	4	4	303	1	0	0	0	0	0	1	0	0	17782	1291	45	2	493	2	ZNF107	7	64167169	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	13429616	64167169	94971494	294	55821											
PTPN12	5782	broad.mit.edu	37	chr7	77267946	77267946	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	tgtgttgctacttagatcatCcagcgggaggtattcactat	9	14	10	8	1	2	1	2	0	0	1	3	2	3	2	1	2	3	3	1	2	4	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:77267946C>T	uc003ugh.2	+	17	2270	c.2179C>T	c.(2179-2181)CCA>TCA	p.P727S	PTPN12_uc011kgp.1_Missense_Mutation_p.P608S|PTPN12_uc011kgq.1_Missense_Mutation_p.P597S|PTPN12_uc010lds.2_Missense_Mutation_p.P459S	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	727						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						CTTAGATCATCCAGCGGGAGG	0.348													33	66					0	0	0	0	T	77267946	T	T	77267946	3	4	303	1	0	0	0	0	1	0	0	0	12844	855	30	2	2245	2	PTPN12	7	77267946	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	13100777	77267946	81870717	295	55822											
PCLO	27445	broad.mit.edu	37	chr7	82451948	82451948	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacggagatggccttctgatGatgattttgagctaccagga	11	11	12	7	1	1	5	0	4	1	1	1	7	1	6	2	3	3	1	2	3	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:82451948G>A	uc003uhx.2	-	20	14943	c.14654C>T	c.(14653-14655)TCA>TTA	p.S4885L	PCLO_uc003uhv.2_Missense_Mutation_p.S4885L|PCLO_uc003uht.1_Missense_Mutation_p.S327L|PCLO_uc003uhu.1_Missense_Mutation_p.S306L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4747	Ser-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCCTTCTGATGATGATTTTGA	0.488													65	182					0	0	0	0	A	82451948	A	A	82451948	3	1	303	1	0	0	0	0	1	0	0	0	11637	1294	45	2	815	2	PCLO	7	82451948	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5184002	82451948	76686715	296	55823											
AKAP9	10142	broad.mit.edu	37	chr7	91622237	91622237	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gatgattcttattctgaacaAggagcacaagacagtccgac	14	9	9	9	1	2	3	0	2	2	1	3	6	3	4	1	1	2	1	1	1	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:91622237A>G	uc003ulg.2	+	5	669	c.444A>G	c.(442-444)CAA>CAG	p.Q148Q	AKAP9_uc003uld.3_Silent_p.Q148Q|AKAP9_uc003ule.2_Silent_p.Q160Q|AKAP9_uc003ulf.2_Silent_p.Q148Q	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	160					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATTCTGAACAAGGAGCACAAG	0.388			T	BRAF	papillary thyroid								27	30					0	0	0	0	G	91622237	G	G	91622237	2	3	303	1	0	0	0	0	0	0	0	1	459	69	3	5		5	AKAP9	7	91622237	Silent	SNP	A	TCGA-HL-7533-01A-11D-2229-08	9170289	91622237	67516426	297	55824											
KRIT1	889	broad.mit.edu	37	chr7	91843283	91843283	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacaggtacgatggattttaGattttcttcactgtaagcac	12	14	8	7	1	2	1	1	0	1	1	2	3	2	2	0	2	3	3	0	2	4	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:91843283G>C	uc003ulq.1	-	14	1912	c.1741C>G	c.(1741-1743)CTA>GTA	p.L581V	KRIT1_uc010lev.1_Missense_Mutation_p.L338V|KRIT1_uc003ulr.1_Missense_Mutation_p.L581V|KRIT1_uc003uls.1_Missense_Mutation_p.L581V|KRIT1_uc003ult.1_Missense_Mutation_p.L533V|KRIT1_uc003ulu.1_Missense_Mutation_p.L581V|KRIT1_uc003ulv.1_Missense_Mutation_p.L581V	NM_194456	NP_919438	O00522	KRIT1_HUMAN	krev interaction trapped 1 isoform 1	581	Required for RAP1A binding.|FERM.				angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATGGATTTTAGATTTTCTTCA	0.338									Familial_Cerebral_Cavernous_Angioma				16	46					0	0	0	0	C	91843283	C	C	91843283	3	2	303	1	0	0	0	0	1	0	0	0	8484	933	33	2	485	2	KRIT1	7	91843283	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	221046	91843283	67295380	298	55825											
CCDC132	55610	broad.mit.edu	37	chr7	92940524	92940524	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggaagaaatcagattacagtCtaaataaagtgaatgcacct	18	9	8	6	0	2	3	1	1	1	2	2	4	2	4	1	1	2	1	1	1	8	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:92940524C>G	uc003umo.2	+	20	1923	c.1795C>G	c.(1795-1797)CTA>GTA	p.L599V	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.L569V|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.L319V	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	599											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			AGATTACAGTCTAAATAAAGT	0.308													28	94					0	0	0	0	G	92940524	G	G	92940524	3	3	303	1	0	0	0	0	1	0	0	0	2779	912	32	2	1915	2	CCDC132	7	92940524	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1097241	92940524	66198139	299	55826											
TMEM130	222865	broad.mit.edu	37	chr7	98457825	98457825	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccccgaagtcccagctgtaGagaaacaaggcggtcttgag	11	7	12	11	2	1	2	0	1	1	1	3	4	3	2	3	2	2	2	3	2	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:98457825G>A	uc003upo.2	-	3	717	c.528C>T	c.(526-528)CTC>CTT	p.L176L	TMEM130_uc011kiq.1_Silent_p.L157L|TMEM130_uc011kir.1_Silent_p.L176L|TMEM130_uc003upn.2_Silent_p.L74L	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	176	Extracellular (Potential).|PKD.					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCCAGCTGTAGAGAAACAAGG	0.607													12	24					0	0	0	0	A	98457825	A	A	98457825	2	1	303	1	0	0	0	0	0	0	0	1	16109	929	33	2		2	TMEM130	7	98457825	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5517301	98457825	60680838	300	55827											
ZNF498	221785	broad.mit.edu	37	chr7	99220256	99220256	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agctgggttctttactgctgGatcgcaggtgagctctgact	6	13	13	9	1	2	2	0	2	2	0	3	3	2	3	0	3	4	5	0	3	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:99220256G>A	uc003url.1	+	6	1001	c.674G>A	c.(673-675)GGA>GAA	p.G225E	ZNF498_uc003urm.1_Missense_Mutation_p.G61E|ZNF498_uc010lge.1_Missense_Mutation_p.G61E|ZNF498_uc003urn.2_RNA|ZNF498_uc010lgf.1_Intron|ZNF498_uc003uro.1_Missense_Mutation_p.G9E	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	225					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					TTTACTGCTGGATCGCAGGTG	0.542													56	45					0	0	0	0	A	99220256	A	A	99220256	3	1	303	1	0	0	0	0	1	0	0	0	18014	1174	41	2	684	2	ZNF498	7	99220256	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	762431	99220256	59918407	301	55828											
GIGYF1	64599	broad.mit.edu	37	chr7	100284283	100284283	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	caatctcaccagggctggcgGagcgccagcggtcgccgtct	6	6	14	15	5	2	0	1	0	2	0	4	1	2	1	3	4	2	1	3	4	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:100284283G>C	uc003uwg.1	-	7	1692	c.683C>G	c.(682-684)TCC>TGC	p.S228C		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	228										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					AGGGCTGGCGGAGCGCCAGCG	0.607													29	92					0	0	0	0	C	100284283	C	C	100284283	3	2	303	1	0	0	0	0	1	0	0	0	6414	1174	41	2	2496	2	GIGYF1	7	100284283	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1064027	100284283	58854380	302	55829											
RELN	5649	broad.mit.edu	37	chr7	103155651	103155651	+	Missense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	cctgaagttttgtcttccatAaacatgtcaaaggcgatcct	11	13	7	10	1	2	1	1	1	1	0	4	2	4	1	3	1	1	1	3	1	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:103155651A>T	uc003vca.2	-	50	8260	c.8100T>A	c.(8098-8100)TTT>TTA	p.F2700L	RELN_uc010liz.2_Missense_Mutation_p.F2700L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2700					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGTCTTCCATAAACATGTCAA	0.498													9	30					0	0	0	0	T	103155651	T	T	103155651	3	4	303	1	0	0	0	0	1	0	0	0	13285	359	13	5	2346	5	RELN	7	103155651	Missense_Mutation	SNP	A	TCGA-HL-7533-01A-11D-2229-08	2871368	103155651	55983012	303	55830											
COG5	10466	broad.mit.edu	37	chr7	107204318	107204318	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctccgaggccagctacagcGacgctgccgccgccaccttc	6	5	11	19	5	0	0	0	0	0	0	2	2	1	0	6	1	4	3	6	1	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:107204318G>A	uc003ved.2	-	1	642	c.117C>T	c.(115-117)GTC>GTT	p.V39V	COG5_uc003vec.2_Silent_p.V39V|COG5_uc003vee.2_Silent_p.V39V|DUS4L_uc003veg.2_5'Flank|DUS4L_uc003veh.2_5'Flank|DUS4L_uc011klw.1_5'Flank|DUS4L_uc011klx.1_5'Flank	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	39					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding	p.V39I(1)		central_nervous_system(2)|skin(2)	4						CAGCTACAGCGACGCTGCCGC	0.672													8	25					0	0	0	0	A	107204318	A	A	107204318	2	1	303	1	0	0	0	0	0	0	0	1	3676	1045	37	1		1	COG5	7	107204318	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4048667	107204318	51934345	304	55831											
CTTNBP2	83992	broad.mit.edu	37	chr7	117431594	117431594	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggtggagaaggagtttgggaGagccctggcttttttggagg	7	11	19	4	0	0	2	0	0	0	2	0	6	0	4	1	7	1	2	1	7	1	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:117431594G>A	uc003vjf.2	-	4	1748	c.1656C>T	c.(1654-1656)CTC>CTT	p.L552L		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	552	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GAGTTTGGGAGAGCCCTGGCT	0.517													40	51					0	0	0	0	A	117431594	A	A	117431594	2	1	303	1	0	0	0	0	0	0	0	1	4062	929	33	2		2	CTTNBP2	7	117431594	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10227276	117431594	41707069	305	55832											
CCDC136	64753	broad.mit.edu	37	chr7	128446796	128446796	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agcaccagaacgtcacatgtGagaaggaaaagctgctggaa	16	5	12	8	1	1	2	1	1	0	2	1	5	1	4	1	2	4	3	1	2	5	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:128446796G>A	uc003vnv.1	+	9	1670	c.1303G>A	c.(1303-1305)GAG>AAG	p.E435K	CCDC136_uc003vnu.1_Intron|CCDC136_uc003vnw.1_Missense_Mutation_p.E382K|CCDC136_uc003vnx.1_Missense_Mutation_p.E251K|CCDC136_uc010llq.1_5'UTR|CCDC136_uc003vny.1_Missense_Mutation_p.E45K	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	435						integral to membrane	protein binding			ovary(2)	2						CGTCACATGTGAGAAGGAAAA	0.592													4	3					0	0	0	0	A	128446796	A	A	128446796	3	1	303	1	0	0	0	0	1	0	0	0	2782	1291	45	2	1337	2	CCDC136	7	128446796	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	11015202	128446796	30691867	306	55833											
PLXNA4	91584	broad.mit.edu	37	chr7	131878881	131878881	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggccgacacacagccacgcaGatctccacgaagcctgcatg	11	4	10	16	3	1	1	0	0	1	1	2	3	1	1	4	1	3	2	4	1	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:131878881G>C	uc003vra.3	-	14	3025	c.2796C>G	c.(2794-2796)ATC>ATG	p.I932M		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	932	IPT/TIG 1.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CAGCCACGCAGATCTCCACGA	0.587													34	85					0	0	0	0	C	131878881	C	C	131878881	3	2	303	1	0	0	0	0	1	0	0	0	12177	932	33	2	2964	2	PLXNA4	7	131878881	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3432085	131878881	27259782	307	55834											
PTN	5764	broad.mit.edu	37	chr7	136938251	136938251	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgcaggggatcttacatctCtgggtcttcatggtttgctt	5	17	11	8	0	4	0	1	0	3	0	5	1	4	1	0	4	3	3	0	4	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:136938251C>T	uc003vtq.2	-	3	612	c.249G>A	c.(247-249)CAG>CAA	p.Q83Q	PTN_uc010lmx.2_Silent_p.Q83Q|PTN_uc003vtr.1_Silent_p.Q83Q	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	83					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			upper_aerodigestive_tract(1)|pancreas(1)	2						TCTTACATCTCTGGGTCTTCA	0.522													8	35					0	0	0	0	T	136938251	T	T	136938251	2	4	303	1	0	0	0	0	0	0	0	1	12831	912	32	2		2	PTN	7	136938251	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5059370	136938251	22200412	308	55835											
UBN2	254048	broad.mit.edu	37	chr7	138946092	138946092	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgattagaaaattccagaaaGagaaggatgcattaaagaag	20	8	10	3	0	0	5	0	1	0	4	1	7	1	6	1	1	1	1	1	1	8	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:138946092G>A	uc011kqr.1	+	6	1000	c.1000G>A	c.(1000-1002)GAG>AAG	p.E334K	UBN2_uc003vuv.2_Missense_Mutation_p.E57K	NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	334	Lys-rich.									ovary(1)|skin(1)	2						ATTCCAGAAAGAGAAGGATGC	0.423													7	15					0	0	0	0	A	138946092	A	A	138946092	3	1	303	1	0	0	0	0	1	0	0	0	16961	943	33	2	1022	2	UBN2	7	138946092	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2007841	138946092	20192571	309	55836											
MGAM	8972	broad.mit.edu	37	chr7	141763322	141763322	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgaatgaaccatcaagcttCgtgaatggggcagtttctcc	11	11	10	9	1	2	3	1	3	1	0	4	3	2	3	2	2	2	3	2	2	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:141763322C>T	uc003vwy.2	+	36	4335	c.4281C>T	c.(4279-4281)TTC>TTT	p.F1427F		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1427	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CATCAAGCTTCGTGAATGGGG	0.493													8	5					0	0	0	0	T	141763322	T	T	141763322	2	4	303	1	0	0	0	0	0	0	0	1	9594	883	31	1		1	MGAM	7	141763322	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2817230	141763322	17375341	310	55837											
OR9A2	135924	broad.mit.edu	37	chr7	142724050	142724050	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggctgaggaagaaatacatgGgggactgcagacgtttatcc	12	8	14	7	1	0	3	0	1	0	2	1	5	1	5	1	4	2	3	1	4	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:142724050G>C	uc003wcc.1	-	1	170	c.170C>G	c.(169-171)CCC>CGC	p.P57R		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					GAAATACATGGGGGACTGCAG	0.438													14	47					0	0	0	0	C	142724050	C	C	142724050	3	2	303	1	0	0	0	0	1	0	0	0	11302	1232	43	4	766	4	OR9A2	7	142724050	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	960728	142724050	16414613	311	55838											
TAS2R40	259286	broad.mit.edu	37	chr7	142919576	142919576	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctttgttcttcctgatgaaGaggaaaatcatagtgctgat	11	14	9	7	0	2	4	1	3	1	1	3	5	3	5	2	1	1	2	2	1	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:142919576G>C	uc011ksx.1	+	1	405	c.405G>C	c.(403-405)AAG>AAC	p.K135N		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	135	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					TCCTGATGAAGAGGAAAATCA	0.423													33	43					0	0	0	0	C	142919576	C	C	142919576	3	2	303	1	0	0	0	0	1	0	0	0	15644	933	33	2	407	2	TAS2R40	7	142919576	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	195526	142919576	16219087	312	55839											
KCNH2	3757	broad.mit.edu	37	chr7	150649526	150649526	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accccacctcctcagagccaGagccgaagatgagcaggtcg	11	4	11	15	2	1	4	1	1	0	3	3	5	2	4	6	1	3	1	6	1	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:150649526G>A	uc003wic.2	-	6	1557	c.1544C>T	c.(1543-1545)TCT>TTT	p.S515F	KCNH2_uc003wib.2_Missense_Mutation_p.S175F|KCNH2_uc011kux.1_Missense_Mutation_p.S419F|KCNH2_uc003wid.2_Missense_Mutation_p.S175F|KCNH2_uc003wie.2_Missense_Mutation_p.S515F	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	515	Helical; Name=Segment S3; (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CTCAGAGCCAGAGCCGAAGAT	0.647													9	18					0	0	0	0	A	150649526	A	A	150649526	3	1	303	1	0	0	0	0	1	0	0	0	8071	942	33	2	2244	2	KCNH2	7	150649526	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7729950	150649526	8489137	313	55840											
ESYT2	57488	broad.mit.edu	37	chr7	158557395	158557395	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acttcattccactttggactGaggttctccttgatgactct	7	16	7	11	0	3	3	1	3	2	0	5	4	4	4	2	2	0	1	2	2	0	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr7:158557395G>A	uc003wob.1	-	9	1284	c.1218C>T	c.(1216-1218)CTC>CTT	p.L406L	ESYT2_uc003woc.1_Silent_p.L230L|ESYT2_uc003wod.1_Silent_p.L406L|ESYT2_uc003woa.1_5'Flank	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	434	C2 1.					integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						ACTTTGGACTGAGGTTCTCCT	0.512													32	62					0	0	0	0	A	158557395	A	A	158557395	2	1	303	1	0	0	0	0	0	0	0	1	5289	1277	45	2		2	ESYT2	7	158557395	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7907869	158557395	581268	314	55841											
DEFB134	613211	broad.mit.edu	37	chr8	11851606	11851606	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tttttatagcatttcttgtgCatttctgatgataatgaatt	10	21	6	4	0	2	3	0	3	2	0	2	3	2	3	0	0	2	2	0	0	4	9	rs148694123		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:11851606C>T	uc011kxn.1	-	2	84	c.84G>A	c.(82-84)ATG>ATA	p.M28I		NM_001033019	NP_001028191	Q4QY38	DB134_HUMAN	beta-defensin 134 precursor	28					defense response to bacterium	extracellular region					0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.159)		ATTTCTTGTGCATTTCTGATG	0.358													14	28					0	0	0	0	T	11851606	T	T	11851606	3	4	303	1	0	0	0	0	1	0	0	0	4440	710	25	4	119	4	DEFB134	8	11851606	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08		11851606	134512416	315	55842											
KIAA1967	57805	broad.mit.edu	37	chr8	22475925	22475925	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcttgcttttgtgttctttGatgccaactggtgtggctac	4	18	11	8	0	1	1	0	1	1	0	1	1	1	1	1	2	5	4	1	2	2	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:22475925G>A	uc003xch.2	+	17	2274	c.2137G>A	c.(2137-2139)GAT>AAT	p.D713N	KIAA1967_uc003xci.2_Missense_Mutation_p.D713N|KIAA1967_uc003xcj.1_Missense_Mutation_p.D382N	NM_199205	NP_954675	Q8N163	K1967_HUMAN	p30 DBC protein	713					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		TGTGTTCTTTGATGCCAACTG	0.512													31	106					0	0	0	0	A	22475925	A	A	22475925	3	1	303	1	0	0	0	0	1	0	0	0	8304	1290	45	2	2199	2	KIAA1967	8	22475925	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10624319	22475925	123888097	316	55843											
KIAA1967	57805	broad.mit.edu	37	chr8	22476211	22476211	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	acagccgccaggagggcctgGatggtggccttcccgaggag	7	5	17	12	2	0	0	0	0	0	0	1	4	1	3	5	6	1	0	5	6	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:22476211G>T	uc003xch.2	+	18	2439	c.2302G>T	c.(2302-2304)GAT>TAT	p.D768Y	KIAA1967_uc003xci.2_Missense_Mutation_p.D768Y|KIAA1967_uc003xcj.1_Missense_Mutation_p.D437Y	NM_199205	NP_954675	Q8N163	K1967_HUMAN	p30 DBC protein	768					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		GGAGGGCCTGGATGGTGGCCT	0.637													20	47					7.21436e-19	7.54971e-19	1	0	T	22476211	T	T	22476211	3	4	303	1	0	0	0	0	1	0	0	0	8304	1174	41	2	2368	2	KIAA1967	8	22476211	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	286	22476211	123887811	317	55844											
ESCO2	157570	broad.mit.edu	37	chr8	27634137	27634137	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagagaaagctgataaaagaGagtagatctacttgtctaaa	18	9	10	4	0	2	4	0	1	2	3	2	7	2	4	0	0	2	2	0	0	7	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:27634137G>C	uc003xgg.2	+	3	395	c.312G>C	c.(310-312)GAG>GAC	p.E104D	ESCO2_uc010luy.1_RNA|ESCO2_uc003xgh.2_Missense_Mutation_p.E104D	NM_001017420	NP_001017420	Q56NI9	ESCO2_HUMAN	establishment of cohesion 1 homolog 2	104					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			central_nervous_system(1)	1		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		TGATAAAAGAGAGTAGATCTA	0.368									SC_Phocomelia_syndrome				3	10					0	0	0	0	C	27634137	C	C	27634137	3	2	303	1	0	0	0	0	1	0	0	0	5273	933	33	2	318	2	ESCO2	8	27634137	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5157926	27634137	118729885	318	55845											
KIAA0146	23514	broad.mit.edu	37	chr8	48625398	48625398	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactcgctggggctgcccctCacagcctcttcttcaaggac	6	9	9	17	1	4	0	2	0	2	0	5	1	4	1	3	3	2	2	3	3	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:48625398C>A	uc003xqd.2	+	15	2161	c.2152C>A	c.(2152-2154)CAC>AAC	p.H718N	KIAA0146_uc011ldb.1_Missense_Mutation_p.H718N|KIAA0146_uc010lxs.2_Missense_Mutation_p.H193N|KIAA0146_uc011ldc.1_Missense_Mutation_p.H648N|KIAA0146_uc011ldd.1_Missense_Mutation_p.H658N|KIAA0146_uc003xqe.2_Missense_Mutation_p.H193N|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.H407N|KIAA0146_uc010lxt.2_Missense_Mutation_p.H407N|KIAA0146_uc011ldf.1_Missense_Mutation_p.H223N|KIAA0146_uc011ldg.1_Missense_Mutation_p.H208N|KIAA0146_uc003xqg.1_5'Flank	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	718											0		Lung NSC(58;0.175)				GGCTGCCCCTCACAGCCTCTT	0.607													29	95					3.76114e-14	3.90802e-14	1	0	A	48625398	A	A	48625398	3	1	303	1	0	0	0	0	1	0	0	0	8196	826	29	2	2210	2	KIAA0146	8	48625398	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	20991261	48625398	97738624	319	55846											
PXDNL	137902	broad.mit.edu	37	chr8	52320924	52320924	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttgattattctggacggtGaaaagagcgctttatggaac	11	12	11	7	2	1	3	0	2	1	1	1	5	1	5	1	3	2	1	1	3	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:52320924G>A	uc003xqu.3	-	17	3361	c.3260C>T	c.(3259-3261)TCA>TTA	p.S1087L	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1087					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TCTGGACGGTGAAAAGAGCGC	0.507													7	33					0	0	0	0	A	52320924	A	A	52320924	3	1	303	1	0	0	0	0	1	0	0	0	12913	1294	45	2	1159	2	PXDNL	8	52320924	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3695526	52320924	94043098	320	55847											
TRAM1	23471	broad.mit.edu	37	chr8	71520408	71520408	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggctcagcactggggggctCttggtgcttttcttgcgaat	4	14	14	9	1	3	0	1	0	2	0	3	1	3	0	0	5	3	4	0	5	1	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:71520408C>T	uc003xyo.1	-	1	197	c.27G>A	c.(25-27)AAG>AAA	p.K9K	TRAM1_uc011lfc.1_Intron	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	9	Cytoplasmic (Potential).				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			CTGGGGGGCTCTTGGTGCTTT	0.642													32	86					0	0	0	0	T	71520408	T	T	71520408	2	4	303	1	0	0	0	0	0	0	0	1	16518	912	32	2		2	TRAM1	8	71520408	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	19199484	71520408	74843614	321	55848											
KCNB2	9312	broad.mit.edu	37	chr8	73850006	73850006	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagaggaggagcttcactGaaatagatactggtgacgac	14	7	14	6	1	1	4	1	2	0	2	1	9	1	6	0	3	2	1	0	3	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:73850006G>A	uc003xzb.2	+	3	3004	c.2416G>A	c.(2416-2418)GAA>AAA	p.E806K		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	806	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GAGCTTCACTGAAATAGATAC	0.527													9	25					0	0	0	0	A	73850006	A	A	73850006	3	1	303	1	0	0	0	0	1	0	0	0	8052	1291	45	2	2422	2	KCNB2	8	73850006	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2329598	73850006	72514016	322	55849											
ZFHX4	79776	broad.mit.edu	37	chr8	77766606	77766606	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atttccatgacgtctctccaGaacagtctacctccacagtt	10	12	5	14	1	2	2	0	1	2	1	6	2	5	2	4	0	2	1	4	0	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:77766606G>T	uc003yav.2	+	10	7701	c.7314G>T	c.(7312-7314)CAG>CAT	p.Q2438H	ZFHX4_uc003yau.1_Missense_Mutation_p.Q2483H|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q2438H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2438						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CGTCTCTCCAGAACAGTCTAC	0.483										HNSCC(33;0.089)			17	24					9.16793e-09	9.38163e-09	1	0	T	77766606	T	T	77766606	3	4	303	1	0	0	0	0	1	0	0	0	17702	933	33	2	7483	2	ZFHX4	8	77766606	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3916600	77766606	68597416	323	55850											
TMEM67	91147	broad.mit.edu	37	chr8	94768086	94768086	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttatttgtaaaaagtgcccaGaaaacatggtgcgcataatt	15	12	8	6	1	0	1	0	0	0	1	0	1	0	1	1	1	3	2	1	1	7	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:94768086G>A	uc011lgk.1	+	2	375	c.304G>A	c.(304-306)GAA>AAA	p.E102K	TMEM67_uc010mau.2_Missense_Mutation_p.E102K|TMEM67_uc010mav.2_Missense_Mutation_p.E102K|TMEM67_uc010mat.1_Missense_Mutation_p.E17K|TMEM67_uc010maw.2_Missense_Mutation_p.E102K|TMEM67_uc003yga.3_Intron	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	102					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			AAAGTGCCCAGAAAACATGGT	0.249													5	19					0	0	0	0	A	94768086	A	A	94768086	3	1	303	1	0	0	0	0	1	0	0	0	16262	943	33	2	310	2	TMEM67	8	94768086	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	17001480	94768086	51595936	324	55851											
KIAA1429	25962	broad.mit.edu	37	chr8	95556119	95556119	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgggggtatgactcggacttCattgatataaaccacacatg	12	11	10	8	1	1	2	1	2	0	0	2	3	1	3	1	3	1	1	1	3	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:95556119C>T	uc003ygo.1	-	2	128	c.115G>A	c.(115-117)GAA>AAA	p.E39K	KIAA1429_uc003ygp.2_Missense_Mutation_p.E39K	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	39					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ACTCGGACTTCATTGATATAA	0.408													36	113					0	0	0	0	T	95556119	T	T	95556119	3	4	303	1	0	0	0	0	1	0	0	0	8270	835	29	2	5469	2	KIAA1429	8	95556119	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	788033	95556119	50807903	325	55852											
MATN2	4147	broad.mit.edu	37	chr8	98991144	98991144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgtgcctcagaaaaccacgGatgtgaacatgagtgtgtaa	13	9	11	8	1	1	3	1	2	0	1	1	4	1	4	2	1	3	1	2	1	4	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:98991144G>A	uc003yic.2	+	6	1220	c.989G>A	c.(988-990)GGA>GAA	p.G330E	MATN2_uc003yib.1_Missense_Mutation_p.G330E|MATN2_uc010mbh.1_Missense_Mutation_p.G330E|MATN2_uc003yid.2_Missense_Mutation_p.G330E|MATN2_uc003yie.1_Missense_Mutation_p.G330E|MATN2_uc010mbi.1_Missense_Mutation_p.G163E	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	330	EGF-like 3.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GAAAACCACGGATGTGAACAT	0.428													9	28					0	0	0	0	A	98991144	A	A	98991144	3	1	303	1	0	0	0	0	1	0	0	0	9387	1174	41	2	1007	2	MATN2	8	98991144	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3435025	98991144	47372878	326	55853											
KCNS2	3788	broad.mit.edu	37	chr8	99440755	99440755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctggacaaccccggctactCagtgctgagcagggtcttca	8	8	12	13	1	3	1	2	1	1	0	3	2	3	2	2	3	4	4	2	3	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:99440755C>T	uc003yin.2	+	2	898	c.548C>T	c.(547-549)TCA>TTA	p.S183L		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	183	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CCCGGCTACTCAGTGCTGAGC	0.592													8	43					0	0	0	0	T	99440755	T	T	99440755	3	4	303	1	0	0	0	0	1	0	0	0	8128	838	29	2	550	2	KCNS2	8	99440755	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	449611	99440755	46923267	327	55854											
PKHD1L1	93035	broad.mit.edu	37	chr8	110457547	110457547	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	attctgttagtgttgtggtgGgaagtaaaggcttggctctg	7	15	15	4	0	2	0	0	0	2	0	2	1	2	1	0	4	0	5	0	4	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:110457547G>A	uc003yne.2	+	38	5553	c.5449G>A	c.(5449-5451)GGA>AGA	p.G1817R		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1817	Extracellular (Potential).|IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGTTGTGGTGGGAAGTAAAGG	0.473										HNSCC(38;0.096)			22	40					0	0	0	0	A	110457547	A	A	110457547	3	1	303	1	0	0	0	0	1	0	0	0	12027	1233	43	4	5599	4	PKHD1L1	8	110457547	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	11016792	110457547	35906475	328	55855											
ATAD2	29028	broad.mit.edu	37	chr8	124383194	124383194	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcatcagttctttgaatatCtttctgttttcctcttgtgt	5	23	5	8	0	6	1	2	1	4	0	7	1	7	1	1	0	0	2	1	0	2	8			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:124383194C>G	uc003yqh.3	-	6	784	c.676G>C	c.(676-678)GAT>CAT	p.D226H	ATAD2_uc011lii.1_Missense_Mutation_p.K17N|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.D226H	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CTTTGAATATCTTTCTGTTTT	0.294													5	22					0	0	0	0	G	124383194	G	G	124383194	3	3	303	1	0	0	0	0	1	0	0	0	1073	913	32	2	3588	2	ATAD2	8	124383194	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	13925647	124383194	21980828	329	55856											
GSDMC	56169	broad.mit.edu	37	chr8	130760899	130760899	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ataggtgatggccaaaccctCactctggagtggggcgagga	10	7	15	9	1	2	1	1	1	1	0	2	4	2	3	2	6	1	0	2	6	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:130760899C>A	uc003ysr.2	-	14	2257	c.1375G>T	c.(1375-1377)GAG>TAG	p.E459*		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	459						mitochondrion				ovary(2)|skin(1)	3						GCCAAACCCTCACTCTGGAGT	0.547													32	64					2.61193e-14	2.71715e-14	1	0	A	130760899	A	A	130760899	4	1	303	1	0	0	0	0	0	1	0	0	6857	835	29	2	155	2	GSDMC	8	130760899	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6377705	130760899	15603123	330	55857											
ASAP1	50807	broad.mit.edu	37	chr8	131179784	131179784	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aacatgtaaaccacttacttCtttctgatccagttgaagag	13	13	6	9	0	2	3	0	2	2	1	3	3	3	3	2	0	3	2	2	0	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:131179784C>G	uc003yta.1	-	10	935	c.907G>C	c.(907-909)GAA>CAA	p.E303Q	ASAP1_uc003ysz.1_Missense_Mutation_p.E111Q|ASAP1_uc011liw.1_Missense_Mutation_p.E296Q	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	303					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						CCACTTACTTCTTTCTGATCC	0.383													48	210					0	0	0	0	G	131179784	G	G	131179784	3	3	303	1	0	0	0	0	1	0	0	0	1012	922	32	2	2562	2	ASAP1	8	131179784	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	418885	131179784	15184238	331	55858											
TG	7038	broad.mit.edu	37	chr8	133883682	133883682	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cctacctccctcagtgtcagGattcaggggactacgcgcct	7	9	10	15	2	3	0	3	0	0	0	4	2	4	2	4	3	2	0	4	3	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:133883682G>C	uc003ytw.2	+	4	405	c.364G>C	c.(364-366)GAT>CAT	p.D122H		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	122	Thyroglobulin type-1 2.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCAGTGTCAGGATTCAGGGGA	0.552													29	79					0	0	0	0	C	133883682	C	C	133883682	3	2	303	1	0	0	0	0	1	0	0	0	15879	1174	41	2	378	2	TG	8	133883682	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2703898	133883682	12480340	332	55859											
SLC45A4	57210	broad.mit.edu	37	chr8	142238343	142238343	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctttggacgggacagccctGaggctgggcttgctttcccc	4	11	13	13	1	1	1	0	1	1	0	2	3	2	3	3	4	2	3	3	4	0	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:142238343G>C	uc003ywd.1	-	1	331	c.23C>G	c.(22-24)TCA>TGA	p.S8*	SLC45A4_uc003ywc.1_Nonsense_Mutation_p.S8*|SLC45A4_uc010meq.1_Intron	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	Error:Variant_position_missing_in_Q5BKX6_after_alignment					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GGACAGCCCTGAGGCTGGGCT	0.547													26	160					0	0	0	0	C	142238343	C	C	142238343	4	2	303	1	0	0	0	0	0	1	0	0	14707	1294	45	2	2405	2	SLC45A4	8	142238343	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	8354661	142238343	4125679	333	55860											
EPPK1	83481	broad.mit.edu	37	chr8	144943051	144943051	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccttaaacctccctgtgctGacgggcaccttcatggccct	6	10	8	17	1	1	1	1	1	0	0	2	1	2	1	5	2	2	2	5	2	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:144943051G>A	uc003zaa.1	-	1	4384	c.4371C>T	c.(4369-4371)GTC>GTT	p.V1457V		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1457						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCCCTGTGCTGACGGGCACCT	0.617													15	23					0	0	0	0	A	144943051	A	A	144943051	2	1	303	1	0	0	0	0	0	0	0	1	5214	1277	45	2		2	EPPK1	8	144943051	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2704708	144943051	1420971	334	55861											
ARHGAP39	80728	broad.mit.edu	37	chr8	145773815	145773815	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaggaagctgggctcccgatCagcgaccttgatgagcatgc	9	7	14	11	2	1	2	1	2	0	0	2	6	2	3	2	2	4	3	2	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr8:145773815C>T	uc003zdt.1	-	6	1210	c.655G>A	c.(655-657)GAT>AAT	p.D219N	ARHGAP39_uc011llk.1_Missense_Mutation_p.D219N|ARHGAP39_uc003zds.1_Missense_Mutation_p.D219N	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	219					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						GGCTCCCGATCAGCGACCTTG	0.701													8	21					0	0	0	0	T	145773815	T	T	145773815	3	4	303	1	0	0	0	0	1	0	0	0	884	826	29	2	2721	2	ARHGAP39	8	145773815	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	830764	145773815	590207	335	55862											
FOXD4	2298	broad.mit.edu	37	chr9	117881	117881	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgaactcggtgccaaactctGaggggtcgctcgggccgccg	6	7	15	13	5	1	2	0	2	1	0	4	2	1	2	3	4	3	1	3	4	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:117881G>C	uc003zfz.2	-	1	537	c.239C>G	c.(238-240)TCA>TGA	p.S80*		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	80					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCCAAACTCTGAGGGGTCGCT	0.711													62	70					0	0	0	0	C	117881	C	C	117881	4	2	303	1	0	0	0	0	0	1	0	0	6031	1294	45	2	1084	2	FOXD4	9	117881	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08		117881	141095550	336	55863											
DOCK8	81704	broad.mit.edu	37	chr9	434937	434937	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agtatctgagcatgctggagGaccacagctacctgcccgtg	9	8	12	12	1	1	1	0	1	1	0	1	3	1	3	3	2	5	4	3	2	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:434937G>A	uc003zgf.2	+	39	5153	c.5041G>A	c.(5041-5043)GAC>AAC	p.D1681N	DOCK8_uc010mgu.2_Missense_Mutation_p.D983N|DOCK8_uc010mgv.2_Missense_Mutation_p.D1581N|DOCK8_uc003zgk.2_Missense_Mutation_p.D1139N	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1681	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CATGCTGGAGGACCACAGCTA	0.483													15	64					0	0	0	0	A	434937	A	A	434937	3	1	303	1	0	0	0	0	1	0	0	0	4715	1174	41	2	5195	2	DOCK8	9	434937	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	317056	434937	140778494	337	55864											
DMRT2	10655	broad.mit.edu	37	chr9	1057048	1057048	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gacaaatcgggtcctgagttGaaaacaccatttgtcaaaga	15	9	9	8	1	1	3	1	2	0	1	3	4	2	3	2	1	1	1	2	1	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:1057048G>C	uc003zha.2	+	4	1661	c.1461G>C	c.(1459-1461)TTG>TTC	p.L487F	DMRT2_uc003zgx.3_Missense_Mutation_p.L254F|DMRT2_uc010mgz.2_Missense_Mutation_p.L254F|DMRT2_uc003zgy.3_Missense_Mutation_p.L331F|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Missense_Mutation_p.L487F	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	487					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		GTCCTGAGTTGAAAACACCAT	0.408													14	35					0	0	0	0	C	1057048	C	C	1057048	3	2	303	1	0	0	0	0	1	0	0	0	4608	1281	45	2	1528	2	DMRT2	9	1057048	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	622111	1057048	140156383	338	55865											
FREM1	158326	broad.mit.edu	37	chr9	14797546	14797546	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggatgacctctactgaaatGgttttaagtatcttatgttt	10	17	9	5	0	2	2	0	2	2	0	2	3	2	3	1	2	1	3	1	2	5	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:14797546G>A	uc003zlm.2	-	21	4379	c.3789C>T	c.(3787-3789)ACC>ACT	p.T1263T	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1263	CSPG 9.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CTACTGAAATGGTTTTAAGTA	0.378													13	56					0	0	0	0	A	14797546	A	A	14797546	2	1	303	1	0	0	0	0	0	0	0	1	6078	1335	47	4		4	FREM1	9	14797546	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	13740498	14797546	126415885	339	55866											
MTAP	4507	broad.mit.edu	37	chr9	21818161	21818161	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctccttgagggaggagattCagcccggcgatattgtcatt	8	11	13	9	2	2	2	2	1	0	1	3	5	3	3	2	3	1	1	2	3	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:21818161C>T	uc003zph.2	+	4	420	c.307C>T	c.(307-309)CAG>TAG	p.Q103*	MTAP_uc003zpi.1_Nonsense_Mutation_p.Q103*|MTAP_uc010mit.2_RNA|MTAP_uc011lnk.1_Nonsense_Mutation_p.Q120*|MTAP_uc011lnl.1_Nonsense_Mutation_p.Q36*	NM_002451	NP_002442	Q13126	MTAP_HUMAN	5'-methylthioadenosine phosphorylase	103					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity			central_nervous_system(1)	1		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	GGAGGAGATTCAGCCCGGCGA	0.453													13	65					0	0	0	0	T	21818161	T	T	21818161	4	4	303	1	0	0	0	0	0	1	0	0	9964	827	29	2	321	2	MTAP	9	21818161	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	7020615	21818161	119395270	340	55867											
TOPORS	10210	broad.mit.edu	37	chr9	32543655	32543655	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	taatctgtgaaggcaagctgGatttctacggaaaaattcag	14	11	10	6	1	3	1	1	1	2	0	3	3	3	3	0	3	2	2	0	3	6	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:32543655G>C	uc003zrb.2	-	3	1035	c.868C>G	c.(868-870)CCA>GCA	p.P290A	TOPORS_uc003zrc.2_Missense_Mutation_p.P223A	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	290	Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		AGGCAAGCTGGATTTCTACGG	0.393													17	48					0	0	0	0	C	32543655	C	C	32543655	3	2	303	1	0	0	0	0	1	0	0	0	16437	1174	41	2	2273	2	TOPORS	9	32543655	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10725494	32543655	108669776	341	55868											
TLN1	7094	broad.mit.edu	37	chr9	35715160	35715160	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagccgctgctgctgctcctCactgtcagggtgggcagctg	4	9	14	14	1	2	0	2	0	0	0	3	0	3	0	2	2	5	6	2	2	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:35715160C>G	uc003zxt.2	-	21	3004	c.2650G>C	c.(2650-2652)GAG>CAG	p.E884Q		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	884					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGCTGCTCCTCACTGTCAGGG	0.602													8	24					0	0	0	0	G	35715160	G	G	35715160	3	3	303	1	0	0	0	0	1	0	0	0	16013	835	29	2	5123	2	TLN1	9	35715160	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3171505	35715160	105498271	342	55869											
TOMM5	401505	broad.mit.edu	37	chr9	37592509	37592509	+	Silent	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tccgggtccagcttcggcgcGaggccctcaatccggaacat	7	7	12	15	5	1	0	1	0	0	0	5	2	4	1	4	4	2	1	4	4	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:37592509G>C	uc010mlx.2	-	1	128	c.21C>G	c.(19-21)CTC>CTG	p.L7L	TOMM5_uc004aae.3_RNA|TOMM5_uc011lql.1_Silent_p.L7L|TOMM5_uc004aaf.2_Silent_p.L7L	NM_001001790	NP_001001790	Q8N4H5	TOM5_HUMAN	translocase of outer mitochondrial membrane 5	7						integral to membrane|mitochondrial outer membrane translocase complex					0						GCTTCGGCGCGAGGCCCTCAA	0.632													17	60					0	0	0	0	C	37592509	C	C	37592509	2	2	303	1	0	0	0	0	0	0	0	1	16426	1045	37	3		3	TOMM5	9	37592509	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1877349	37592509	103620922	343	55870											
PGM5	5239	broad.mit.edu	37	chr9	71144510	71144510	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgagccctctcatagccatcGcactgaaaatatcccagatt	12	10	6	13	1	1	3	1	2	1	1	4	3	2	3	3	0	2	1	3	0	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:71144510G>A	uc004agr.2	+	11	1871	c.1642G>A	c.(1642-1644)GCA>ACA	p.A548T		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	548					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						CATAGCCATCGCACTGAAAAT	0.483													3	10					0	0	0	0	A	71144510	A	A	71144510	3	1	303	1	0	0	0	0	1	0	0	0	11856	1087	38	1	1684	1	PGM5	9	71144510	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	33552001	71144510	70068921	344	55871											
SHC3	53358	broad.mit.edu	37	chr9	91652995	91652995	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagcccgggttggtggtgctCttcctgaccaggaagtctcc	5	10	14	12	1	2	1	0	1	2	0	4	3	3	2	4	4	2	2	4	4	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:91652995C>T	uc004aqg.2	-	11	1876	c.1569G>A	c.(1567-1569)AAG>AAA	p.K523K		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	523	SH2.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						TGGTGGTGCTCTTCCTGACCA	0.607													36	103					0	0	0	0	T	91652995	T	T	91652995	2	4	303	1	0	0	0	0	0	0	0	1	14337	912	32	2		2	SHC3	9	91652995	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	20508485	91652995	49560436	345	55872											
WNK2	65268	broad.mit.edu	37	chr9	96051216	96051216	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctcccctcctgtgactgctCtgccccaagatggagcagct	6	9	9	17	0	1	2	0	1	1	1	3	3	3	3	6	1	4	3	6	1	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:96051216C>G	uc004ati.1	+	20	4291	c.4291C>G	c.(4291-4293)CTG>GTG	p.L1431V	WNK2_uc011lud.1_Missense_Mutation_p.L1394V|WNK2_uc004atj.2_Missense_Mutation_p.L1394V|WNK2_uc004atk.2_Missense_Mutation_p.L1031V|WNK2_uc004atl.1_5'UTR	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1431					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						TGTGACTGCTCTGCCCCAAGA	0.682													4	8					0	0	0	0	G	96051216	G	G	96051216	3	3	303	1	0	0	0	0	1	0	0	0	17446	912	32	2	4254	2	WNK2	9	96051216	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4398221	96051216	45162215	346	55873											
PTCH1	5727	broad.mit.edu	37	chr9	98209310	98209310	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaaggcacgtgggggtcctCaaacaggccgtggtcagtct	9	7	15	10	2	3	0	2	0	1	0	4	1	4	0	2	5	1	1	2	5	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:98209310C>G	uc004avk.3	-	23	4416	c.4228G>C	c.(4228-4230)GAG>CAG	p.E1410Q	PTCH1_uc010mrn.2_Missense_Mutation_p.E202Q|PTCH1_uc010mro.2_Missense_Mutation_p.E1259Q|PTCH1_uc010mrp.2_Missense_Mutation_p.E1259Q|PTCH1_uc010mrq.2_Missense_Mutation_p.E1259Q|PTCH1_uc004avl.3_Missense_Mutation_p.E1259Q|PTCH1_uc010mrr.2_Missense_Mutation_p.E1344Q|PTCH1_uc004avm.3_Missense_Mutation_p.E1409Q	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1410	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TGGGGGTCCTCAAACAGGCCG	0.672									Basal_Cell_Nevus_syndrome				19	86					0	0	0	0	G	98209310	G	G	98209310	3	3	303	1	0	0	0	0	1	0	0	0	12792	835	29	2	119	2	PTCH1	9	98209310	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2158094	98209310	43004121	347	55874											
FAM22G	441457	broad.mit.edu	37	chr9	99699595	99699595	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgggaaaagggcaaagtggAgcagccgcaggaagaggacg	15	1	18	7	3	0	1	0	0	0	1	0	5	0	5	1	5	2	3	1	5	4	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:99699595A>C	uc004awq.1	+	5	1947	c.1232A>C	c.(1231-1233)GAG>GCG	p.E411A	HIATL2_uc004awr.1_Intron	NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	411										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)				GGCAAAGTGGAGCAGCCGCAG	0.592													39	100					0	0	0	0	C	99699595	C	C	99699595	3	2	303	1	0	0	0	0	1	0	0	0	5574	304	11	5	1250	5	FAM22G	9	99699595	Missense_Mutation	SNP	A	TCGA-HL-7533-01A-11D-2229-08	1490285	99699595	41513836	348	55875											
AKNA	80709	broad.mit.edu	37	chr9	117139665	117139665	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctcataccccaaccttgagGagctctctccagcctcctca	8	9	5	19	0	3	1	2	1	1	0	6	2	5	2	7	1	4	1	7	1	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:117139665G>A	uc004biq.3	-	2	557	c.422C>T	c.(421-423)TCC>TTC	p.S141F	AKNA_uc004bio.3_5'Flank|AKNA_uc004bip.3_Missense_Mutation_p.S60F|AKNA_uc004bir.3_Missense_Mutation_p.S141F|AKNA_uc004bis.3_Missense_Mutation_p.S141F|AKNA_uc010mve.2_Missense_Mutation_p.S22F|AKNA_uc004biu.1_Intron|AKNA_uc004biv.1_Missense_Mutation_p.S141F|AKNA_uc004biw.1_Missense_Mutation_p.S141F	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						CAACCTTGAGGAGCTCTCTCC	0.622													6	13					0	0	0	0	A	117139665	A	A	117139665	3	1	303	1	0	0	0	0	1	0	0	0	463	1174	41	2	3977	2	AKNA	9	117139665	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	17440070	117139665	24073766	349	55876											
NTNG2	84628	broad.mit.edu	37	chr9	135116365	135116365	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccggcttctgcgagtgccgcGagggcgcggcgggccccaag	4	4	18	15	7	1	0	0	0	1	0	1	2	1	0	4	4	2	1	4	4	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:135116365G>A	uc004cbh.2	+	7	2067	c.1291G>A	c.(1291-1293)GAG>AAG	p.E431K		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	431	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		CGAGTGCCGCGAGGGCGCGGC	0.721													5	12					0	0	0	0	A	135116365	A	A	135116365	3	1	303	1	0	0	0	0	1	0	0	0	10759	1059	37	1	1313	1	NTNG2	9	135116365	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	17976700	135116365	6097066	350	55877											
C9orf171	389799	broad.mit.edu	37	chr9	135447846	135447846	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaagcccaccgggaagaGtgtgccgtgcgccaggggac	10	5	15	11	3	0	1	0	0	0	1	0	3	0	3	4	3	3	0	4	3	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:135447846G>A	uc004cbn.2	+	7	960	c.912G>A	c.(910-912)GAG>GAA	p.E304E	C9orf171_uc004cbo.2_Silent_p.E268E	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	304										ovary(4)|large_intestine(1)	5						ACCGGGAAGAGTGTGCCGTGC	0.607													23	39					0	0	0	0	A	135447846	A	A	135447846	2	1	303	1	0	0	0	0	0	0	0	1	2482	1020	36	4		4	C9orf171	9	135447846	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	331481	135447846	5765585	351	55878											
NDOR1	27158	broad.mit.edu	37	chr9	140108741	140108741	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtagctcaccccggctctCaggagcccccgtcagagtcg	6	6	13	16	3	3	1	3	0	1	1	5	2	3	2	4	3	2	3	4	3	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:140108741C>G	uc004clw.2	+	6	709	c.598C>G	c.(598-600)CAG>GAG	p.Q200E	NDOR1_uc004clx.2_Missense_Mutation_p.Q200E|NDOR1_uc011mes.1_Missense_Mutation_p.Q200E|NDOR1_uc004cly.2_Missense_Mutation_p.Q166E	NM_014434	NP_055249	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	200					cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CCCCGGCTCTCAGGAGCCCCC	0.642													8	40					0	0	0	0	G	140108741	G	G	140108741	3	3	303	1	0	0	0	0	1	0	0	0	10303	827	29	2	620	2	NDOR1	9	140108741	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4660895	140108741	1104690	352	55879											
ENTPD8	377841	broad.mit.edu	37	chr9	140330690	140330690	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtgtggtctggtagccgctGaggtagcacgggtgacggag	7	8	19	7	3	1	2	0	2	1	0	1	3	1	3	1	5	2	4	1	5	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr9:140330690G>A	uc004cmw.2	-	7	1009	c.825C>T	c.(823-825)CTC>CTT	p.L275L	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Silent_p.L275L	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	275	Extracellular (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		GGTAGCCGCTGAGGTAGCACG	0.706													7	17					0	0	0	0	A	140330690	A	A	140330690	2	1	303	1	0	0	0	0	0	0	0	1	5169	1277	45	2		2	ENTPD8	9	140330690	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	221949	140330690	882741	353	55880											
SFMBT2	57713	broad.mit.edu	37	chr10	7217983	7217983	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttggtatgaatggagcagttCtctgggcagttttcagatat	9	15	12	5	0	2	2	1	1	1	1	3	3	2	3	0	3	1	5	0	3	3	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:7217983C>T	uc009xio.1	-	17	2044	c.1953G>A	c.(1951-1953)GAG>GAA	p.E651E	SFMBT2_uc001ijn.1_Silent_p.E651E|SFMBT2_uc010qay.1_Silent_p.E486E	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	651					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						TGGAGCAGTTCTCTGGGCAGT	0.423													37	110					0	0	0	0	T	7217983	T	T	7217983	2	4	303	1	0	0	0	0	0	0	0	1	14223	912	32	2		2	SFMBT2	10	7217983	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08		7217983	128316764	354	55881											
ITIH5	80760	broad.mit.edu	37	chr10	7684025	7684025	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgatggtagacttcactGagaattctgtcatcaaaggt	14	12	9	6	0	4	3	3	2	1	2	4	4	4	3	0	2	0	1	0	2	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:7684025G>C	uc001ijq.2	-	3	243	c.164C>G	c.(163-165)TCA>TGA	p.S55*	ITIH5_uc001ijr.1_Nonsense_Mutation_p.S55*	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	55	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						AGACTTCACTGAGAATTCTGT	0.423													13	48					0	0	0	0	C	7684025	C	C	7684025	4	2	303	1	0	0	0	0	0	1	0	0	7946	1294	45	2	2849	2	ITIH5	10	7684025	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	466042	7684025	127850722	355	55882											
FAM188A	80013	broad.mit.edu	37	chr10	15828635	15828635	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tctggatctaatttattcttCatgagatttatactacgggg	10	17	8	6	1	4	1	1	1	3	1	4	3	4	2	0	3	2	0	0	3	5	9			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:15828635C>T	uc001iod.1	-	13	1262	c.1041G>A	c.(1039-1041)ATG>ATA	p.M347I	FAM188A_uc001ioe.1_Missense_Mutation_p.M174I	NM_024948	NP_079224	Q9H8M7	F188A_HUMAN	chromosome 10 open reading frame 97	347					apoptosis	nucleus	calcium ion binding			ovary(1)	1						ATTTATTCTTCATGAGATTTA	0.323													12	30					0	0	0	0	T	15828635	T	T	15828635	3	4	303	1	0	0	0	0	1	0	0	0	5542	826	29	2	308	2	FAM188A	10	15828635	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	8144610	15828635	119706112	356	55883											
GPR158	57512	broad.mit.edu	37	chr10	25887024	25887024	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcccacagcacttatgaccaCgtgagagaccaaacggaaga	15	5	9	12	2	0	4	0	2	0	2	1	6	1	5	3	1	2	1	3	1	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:25887024C>T	uc001isj.2	+	11	2529	c.2469C>T	c.(2467-2469)CAC>CAT	p.H823H	GPR158_uc001isk.2_Silent_p.H198H	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	823	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CTTATGACCACGTGAGAGACC	0.498													29	88					0	0	0	0	T	25887024	T	T	25887024	2	4	303	1	0	0	0	0	0	0	0	1	6701	535	19	1		1	GPR158	10	25887024	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	10058389	25887024	109647723	357	55884											
ARMC4	55130	broad.mit.edu	37	chr10	28250565	28250565	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atctgcacttgcttcctgacGatggtcaggtggttcttcat	6	15	10	10	1	4	1	2	1	2	0	5	2	5	1	1	3	2	3	1	3	0	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:28250565G>A	uc009xky.2	-	10	1416	c.1318C>T	c.(1318-1320)CGT>TGT	p.R440C	ARMC4_uc010qds.1_5'UTR|ARMC4_uc010qdt.1_Missense_Mutation_p.R132C|ARMC4_uc001itz.2_Missense_Mutation_p.R440C|ARMC4_uc010qdu.1_Missense_Mutation_p.R132C	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	440							binding			ovary(4)|skin(2)	6						GCTTCCTGACGATGGTCAGGT	0.398													16	30					0	0	0	0	A	28250565	A	A	28250565	3	1	303	1	0	0	0	0	1	0	0	0	955	1058	37	1	1860	1	ARMC4	10	28250565	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2363541	28250565	107284182	358	55885											
KIAA1462	57608	broad.mit.edu	37	chr10	30316127	30316127	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgcgggcagtggttttgcgtCacttgatcttgaagacattc	7	13	12	9	3	2	3	1	2	1	1	3	3	2	3	0	2	1	2	0	2	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:30316127C>G	uc001iux.2	-	2	3009	c.2950G>C	c.(2950-2952)GAC>CAC	p.D984H	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.D846H|KIAA1462_uc009xle.1_Missense_Mutation_p.D984H	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	984										ovary(4)	4						GGTTTTGCGTCACTTGATCTT	0.527													23	82					0	0	0	0	G	30316127	G	G	30316127	3	3	303	1	0	0	0	0	1	0	0	0	8273	826	29	2	1137	2	KIAA1462	10	30316127	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2065562	30316127	105218620	359	55886											
KIF5B	3799	broad.mit.edu	37	chr10	32324561	32324561	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctaatgaatcttgaaggattCttgtcattttactatctcga	11	17	6	7	1	4	2	1	2	3	0	5	4	4	3	0	1	1	0	0	1	5	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:32324561C>T	uc001iwe.3	-	10	1321	c.851G>A	c.(850-852)AGA>AAA	p.R284K		NM_004521	NP_004512	P33176	KINH_HUMAN	kinesin family member 5B	284	Kinesin-motor.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)				TTGAAGGATTCTTGTCATTTT	0.313													8	23					0	0	0	0	T	32324561	T	T	32324561	3	4	303	1	0	0	0	0	1	0	0	0	8345	913	32	2	2104	2	KIF5B	10	32324561	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2008434	32324561	103210186	360	55887											
PARD3	56288	broad.mit.edu	37	chr10	34408651	34408651	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagtgtcgcccgctctgcgtCgccggccgtgcgttcggctg	1	9	16	15	8	1	0	0	0	1	0	4	1	1	0	3	2	2	3	3	2	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:34408651C>T	uc010qej.1	-	24	3567	c.3567G>A	c.(3565-3567)GCG>GCA	p.A1189A	PARD3_uc010qek.1_Silent_p.A1186A|PARD3_uc010qel.1_Silent_p.A1152A|PARD3_uc010qem.1_Silent_p.A1173A|PARD3_uc010qen.1_Silent_p.A1143A|PARD3_uc010qeo.1_Silent_p.A1106A|PARD3_uc010qep.1_Silent_p.A1099A|PARD3_uc010qeq.1_Silent_p.A1077A	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1189					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CGCTCTGCGTCGCCGGCCGTG	0.587													9	11					0	0	0	0	T	34408651	T	T	34408651	2	4	303	1	0	0	0	0	0	0	0	1	11497	871	31	1		1	PARD3	10	34408651	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2084090	34408651	101126096	361	55888											
OGDHL	55753	broad.mit.edu	37	chr10	50944441	50944441	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ggccactttctcctccaggtCctggctgctccgctccttca	3	12	8	18	1	2	0	1	0	1	0	7	0	6	0	6	3	1	3	6	3	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:50944441C>G	uc001jie.2	-	21	2858	c.2716G>C	c.(2716-2718)GAC>CAC	p.D906H	OGDHL_uc009xog.2_Missense_Mutation_p.D933H|OGDHL_uc010qgt.1_Missense_Mutation_p.D849H|OGDHL_uc010qgu.1_Missense_Mutation_p.D697H	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	906					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						TCCTCCAGGTCCTGGCTGCTC	0.627													34	102					0	0	0	0	G	50944441	G	G	50944441	3	3	303	1	0	0	0	0	1	0	0	0	10894	855	30	2	328	2	OGDHL	10	50944441	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	16535790	50944441	84590306	362	55889											
PCDH15	65217	broad.mit.edu	37	chr10	55663095	55663095	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cactgggggatgattattttCatcctgaatctcaatgtata	11	15	8	7	0	2	2	2	2	1	0	4	3	3	3	1	2	0	1	1	2	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:55663095C>A	uc001jju.1	-	26	3804	c.3409G>T	c.(3409-3411)GAA>TAA	p.E1137*	PCDH15_uc010qhq.1_Nonsense_Mutation_p.E1142*|PCDH15_uc010qhr.1_Nonsense_Mutation_p.E1137*|PCDH15_uc010qhs.1_Nonsense_Mutation_p.E1149*|PCDH15_uc010qht.1_Nonsense_Mutation_p.E1144*|PCDH15_uc010qhu.1_Nonsense_Mutation_p.E1137*|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Nonsense_Mutation_p.E1137*|PCDH15_uc010qhw.1_Nonsense_Mutation_p.E1100*|PCDH15_uc010qhx.1_Nonsense_Mutation_p.E1066*|PCDH15_uc010qhy.1_Nonsense_Mutation_p.E1142*|PCDH15_uc010qhz.1_Nonsense_Mutation_p.E1137*|PCDH15_uc010qia.1_Nonsense_Mutation_p.E1115*|PCDH15_uc010qib.1_Nonsense_Mutation_p.E1115*	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1137	Cadherin 10.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGATTATTTTCATCCTGAATC	0.388										HNSCC(58;0.16)			13	36					7.93312e-07	8.09916e-07	1	0	A	55663095	A	A	55663095	4	1	303	1	0	0	0	0	0	1	0	0	11565	835	29	2	4109	2	PCDH15	10	55663095	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4718654	55663095	79871652	363	55890											
PCDH15	65217	broad.mit.edu	37	chr10	56287638	56287638	+	Splice_Site	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcccctagctagtttgcaatCtaaagagagaaaataaccaa	17	9	6	9	0	1	2	0	0	1	2	2	3	2	2	3	0	3	3	3	0	9	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:56287638C>G	uc001jju.1	-	3	487	c.92_splice	c.e3-1	p.D31_splice	PCDH15_uc010qhq.1_Splice_Site_p.D36_splice|PCDH15_uc010qhr.1_Splice_Site_p.D31_splice|PCDH15_uc010qhs.1_Splice_Site_p.D36_splice|PCDH15_uc010qht.1_Splice_Site_p.D31_splice|PCDH15_uc010qhu.1_Splice_Site_p.D31_splice|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Splice_Site_p.D31_splice|PCDH15_uc010qhw.1_Splice_Site_p.D31_splice|PCDH15_uc010qhx.1_Splice_Site_p.D31_splice|PCDH15_uc010qhy.1_Splice_Site_p.D36_splice|PCDH15_uc010qhz.1_Splice_Site_p.D31_splice|PCDH15_uc010qia.1_Intron|PCDH15_uc010qib.1_Intron|PCDH15_uc001jjw.2_Splice_Site_p.D31_splice	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor						equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AGTTTGCAATCTAAAGAGAGA	0.328										HNSCC(58;0.16)			15	29					0	0	0	0	G	56287638	G	G	56287638	5	3	303	1	0	0	0	0	0	0	1	0	11565	927	32	2	7544	2	PCDH15	10	56287638	Splice_Site	SNP	C	TCGA-HL-7533-01A-11D-2229-08	624543	56287638	79247109	364	55891											
TTC18	118491	broad.mit.edu	37	chr10	75090940	75090940	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggggcatatttaccttttCagttttgccagctttccctt	6	17	8	10	0	1	0	1	0	0	0	2	0	2	0	3	2	3	3	3	2	2	9			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:75090940C>T	uc009xrc.2	-	9	1103	c.982G>A	c.(982-984)GAA>AAA	p.E328K	TTC18_uc001jty.2_Missense_Mutation_p.E328K|TTC18_uc009xrd.1_Missense_Mutation_p.E136K	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	328							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					TTTACCTTTTCAGTTTTGCCA	0.403													7	11					0	0	0	0	T	75090940	T	T	75090940	3	4	303	1	0	0	0	0	1	0	0	0	16753	835	29	2	2463	2	TTC18	10	75090940	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	18803302	75090940	60443807	365	55892											
VCL	7414	broad.mit.edu	37	chr10	75868828	75868828	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaaaggatgaagagttccctGagcagaaggccggggaggtg	13	5	17	6	1	0	4	0	2	0	2	1	6	1	6	2	5	1	2	2	5	4	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:75868828G>A	uc001jwd.2	+	18	2753	c.2659G>A	c.(2659-2661)GAG>AAG	p.E887K	VCL_uc009xrr.2_Missense_Mutation_p.E636K|VCL_uc010qky.1_Missense_Mutation_p.E794K|VCL_uc001jwe.2_Missense_Mutation_p.E887K|VCL_uc010qkz.1_Missense_Mutation_p.E148K	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	887	C-terminal tail.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					AGAGTTCCCTGAGCAGAAGGC	0.547													15	36					0	0	0	0	A	75868828	A	A	75868828	3	1	303	1	0	0	0	0	1	0	0	0	17207	1291	45	2	2729	2	VCL	10	75868828	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	777888	75868828	59665919	366	55893											
POLR3A	11128	broad.mit.edu	37	chr10	79785418	79785418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgctctgaagtaccctacatGaaaacacggcaactccaggt	13	8	8	12	1	1	2	0	2	1	0	2	2	2	2	2	2	5	3	2	2	6	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:79785418G>A	uc001jzn.2	-	3	374	c.280C>T	c.(280-282)CAT>TAT	p.H94Y		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	94					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			TACCCTACATGAAAACACGGC	0.483													11	38					0	0	0	0	A	79785418	A	A	79785418	3	1	303	1	0	0	0	0	1	0	0	0	12283	1290	45	2	4008	2	POLR3A	10	79785418	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3916590	79785418	55749329	367	55894											
FAM190B	54462	broad.mit.edu	37	chr10	86259714	86259714	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttccaccgcaccgcagacaGagtgagtctgtgtctctcac	8	9	10	14	2	3	3	1	1	2	2	5	3	4	3	3	0	0	3	3	0	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:86259714G>A	uc001kdh.1	+	10	2603	c.2409G>A	c.(2407-2409)CAG>CAA	p.Q803Q	FAM190B_uc010qmd.1_Intron|FAM190B_uc001kdi.1_Intron|FAM190B_uc010qme.1_Silent_p.Q230Q	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	803										ovary(3)|skin(1)	4						ACCGCAGACAGAGTGAGTCTG	0.567													37	69					0	0	0	0	A	86259714	A	A	86259714	2	1	303	1	0	0	0	0	0	0	0	1	5550	956	33	2		2	FAM190B	10	86259714	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	6474296	86259714	49275033	368	55895											
GLUD1	2746	broad.mit.edu	37	chr10	88819941	88819941	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aataaccataatgtttctctCcaggaagatcttgtcagctt	12	14	6	9	0	3	1	1	0	2	1	5	2	4	2	2	1	2	2	2	1	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:88819941C>T	uc001keh.2	-	9	1352	c.1255G>A	c.(1255-1257)GAG>AAG	p.E419K	GLUD1_uc001keg.2_Missense_Mutation_p.E252K|GLUD1_uc010qmp.1_Missense_Mutation_p.E286K	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	419					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATGTTTCTCTCCAGGAAGATC	0.398													16	60					0	0	0	0	T	88819941	T	T	88819941	3	4	303	1	0	0	0	0	1	0	0	0	6513	864	30	2	441	2	GLUD1	10	88819941	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2560227	88819941	46714806	369	55896											
PPP1R3C	5507	broad.mit.edu	37	chr10	93389941	93389941	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggtaagaaatgcagaactCaattttctgctcagttggaa	14	12	9	6	0	3	2	2	0	1	2	3	3	3	3	0	2	3	4	0	2	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:93389941C>G	uc001kho.2	-	2	829	c.697G>C	c.(697-699)GAG>CAG	p.E233Q		NM_005398	NP_005389	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	233	Interaction with EPM2A.|CBM21.						protein serine/threonine phosphatase activity			breast(1)	1		Colorectal(252;0.235)				ATGCAGAACTCAATTTTCTGC	0.403													25	58					0	0	0	0	G	93389941	G	G	93389941	3	3	303	1	0	0	0	0	1	0	0	0	12433	835	29	2	260	2	PPP1R3C	10	93389941	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4570000	93389941	42144806	370	55897											
TNKS2	80351	broad.mit.edu	37	chr10	93614860	93614860	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctgtctcctgatgataaaGagtttcagtctgtggaggaa	11	13	11	6	0	4	3	1	2	3	1	5	5	4	5	1	2	0	1	1	2	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:93614860G>C	uc001khp.2	+	22	3187	c.2890G>C	c.(2890-2892)GAG>CAG	p.E964Q		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	964	PARP catalytic.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				TGATGATAAAGAGTTTCAGTC	0.338													16	29					0	0	0	0	C	93614860	C	C	93614860	3	2	303	1	0	0	0	0	1	0	0	0	16387	943	33	2	2976	2	TNKS2	10	93614860	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	224919	93614860	41919887	371	55898											
IDE	3416	broad.mit.edu	37	chr10	94291603	94291603	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcacattcttctcatgttctGaatcaactgcattcacctct	9	16	3	13	0	7	1	4	1	4	0	8	1	7	1	1	0	2	2	1	0	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:94291603G>A	uc001kia.2	-	4	639	c.563C>T	c.(562-564)TCA>TTA	p.S188L		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	188					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTCATGTTCTGAATCAACTGC	0.403													14	23					0	0	0	0	A	94291603	A	A	94291603	3	1	303	1	0	0	0	0	1	0	0	0	7532	1294	45	2	2584	2	IDE	10	94291603	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	676743	94291603	41243144	372	55899											
ARHGAP19	84986	broad.mit.edu	37	chr10	99025847	99025847	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggctgacctcgaagggaaGaatcattgcagatcacaaaa	15	7	11	8	1	2	3	2	1	0	2	3	5	2	4	1	2	1	2	1	2	5	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:99025847G>C	uc001knb.2	-	2	121	c.92C>G	c.(91-93)TCT>TGT	p.S31C	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Missense_Mutation_p.S22C|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Missense_Mutation_p.S31C|ARHGAP19_uc009xvk.2_Intron	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	31					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)		TCGAAGGGAAGAATCATTGCA	0.393													9	51					0	0	0	0	C	99025847	C	C	99025847	3	2	303	1	0	0	0	0	1	0	0	0	869	942	33	2	1436	2	ARHGAP19	10	99025847	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4734244	99025847	36508900	373	55900											
EXOSC1	51013	broad.mit.edu	37	chr10	99205728	99205728	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaccggggatgcagtatctCacaggtggcgccatgattgc	8	10	13	10	2	1	1	1	1	1	0	2	2	1	2	2	4	3	2	2	4	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:99205728C>T	uc001kni.2	-	1	41	c.15G>A	c.(13-15)GTG>GTA	p.V5V	EXOSC1_uc009xvp.1_RNA|ZDHHC16_uc001knp.2_5'Flank|ZDHHC16_uc001knk.2_5'Flank|ZDHHC16_uc001knl.2_5'Flank|ZDHHC16_uc001knm.2_5'Flank|ZDHHC16_uc001knn.2_5'Flank|ZDHHC16_uc010qow.1_5'Flank|ZDHHC16_uc009xvq.2_5'Flank|ZDHHC16_uc001kno.2_5'Flank|ZDHHC16_uc001knj.2_5'Flank	NM_016046	NP_057130	Q9Y3B2	EXOS1_HUMAN	exosomal core protein CSL4	5					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	protein binding|RNA binding				0		Renal(717;0.000147)|Colorectal(252;0.00205)|Ovarian(717;0.00965)		all cancers(201;8.29e-42)|Epithelial(162;5.7e-33)|BRCA - Breast invasive adenocarcinoma(275;0.000315)|Kidney(138;0.000832)|KIRC - Kidney renal clear cell carcinoma(50;0.00269)|STAD - Stomach adenocarcinoma(243;0.202)		TGCAGTATCTCACAGGTGGCG	0.557											OREG0020413	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	41					0	0	0	0	T	99205728	T	T	99205728	2	4	303	1	0	0	0	0	0	0	0	1	5337	813	29	2		2	EXOSC1	10	99205728	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	179881	99205728	36329019	374	55901											
ZFYVE27	118813	broad.mit.edu	37	chr10	99510111	99510111	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtctgagtacagggcatctCtgcagcagaggatgaaccca	11	8	12	10	0	2	3	0	2	2	1	3	4	2	4	1	2	4	4	1	2	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:99510111C>G	uc001koo.2	+	7	888	c.688C>G	c.(688-690)CTG>GTG	p.L230V	ZFYVE27_uc001kon.2_Missense_Mutation_p.L230V|ZFYVE27_uc001koq.2_Missense_Mutation_p.L144V|ZFYVE27_uc010qpa.1_Missense_Mutation_p.L112V|ZFYVE27_uc001kop.2_Missense_Mutation_p.L230V|ZFYVE27_uc010qpb.1_Missense_Mutation_p.L132V|ZFYVE27_uc010qpc.1_RNA|ZFYVE27_uc010qpd.1_Missense_Mutation_p.L198V|ZFYVE27_uc001kok.1_RNA|ZFYVE27_uc001kol.1_Missense_Mutation_p.L230V|ZFYVE27_uc001kom.1_Missense_Mutation_p.L230V	NM_144588	NP_653189	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27 isoform	230	Extracellular (Potential).				cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		CAGGGCATCTCTGCAGCAGAG	0.542													22	51					0	0	0	0	G	99510111	G	G	99510111	3	3	303	1	0	0	0	0	1	0	0	0	17736	912	32	2	710	2	ZFYVE27	10	99510111	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	304383	99510111	36024636	375	55902											
C10orf28	27291	broad.mit.edu	37	chr10	99968101	99968101	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actaaatatcaatcctgataGaaaggagcataattgtagag	18	10	8	5	0	1	3	1	1	0	2	2	4	2	4	1	1	1	2	1	1	8	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:99968101G>C	uc001kow.3	+	4	525	c.230G>C	c.(229-231)AGA>ACA	p.R77T	C10orf28_uc001kox.3_Missense_Mutation_p.R77T|C10orf28_uc001koy.3_Missense_Mutation_p.R77T|C10orf28_uc009xvx.2_Missense_Mutation_p.R77T|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	77							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		AATCCTGATAGAAAGGAGCAT	0.348													15	42					0	0	0	0	C	99968101	C	C	99968101	3	2	303	1	0	0	0	0	1	0	0	0	1607	942	33	2	232	2	C10orf28	10	99968101	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	457990	99968101	35566646	376	55903											
LOXL4	84171	broad.mit.edu	37	chr10	100017517	100017517	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagtcgctgagggtccgctCatatcccctgcagcgcacct	6	8	11	16	3	1	1	1	1	0	0	4	1	3	1	4	1	2	5	4	1	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:100017517C>T	uc001kpa.1	-	8	1301	c.1150G>A	c.(1150-1152)GAG>AAG	p.E384K		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	384	SRCR 3.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		AGGGTCCGCTCATATCCCCTG	0.592													33	77					0	0	0	0	T	100017517	T	T	100017517	3	4	303	1	0	0	0	0	1	0	0	0	8952	835	29	2	1152	2	LOXL4	10	100017517	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	49416	100017517	35517230	377	55904											
DNMBP	23268	broad.mit.edu	37	chr10	101668784	101668784	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgtagtctctttctgtctGaagaagttcttctatgacct	9	17	7	8	0	5	3	0	2	5	1	6	3	5	3	1	0	0	2	1	0	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:101668784G>C	uc001kqj.2	-	5	2472	c.2380C>G	c.(2380-2382)CAG>GAG	p.Q794E	DNMBP_uc001kqg.2_Missense_Mutation_p.Q82E|DNMBP_uc001kqh.2_Missense_Mutation_p.Q426E	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	794	DH.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CTTTCTGTCTGAAGAAGTTCT	0.507													16	20					0	0	0	0	C	101668784	C	C	101668784	3	2	303	1	0	0	0	0	1	0	0	0	4696	1299	45	2	2405	2	DNMBP	10	101668784	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1651267	101668784	33865963	378	55905											
PAX2	5076	broad.mit.edu	37	chr10	102568884	102568884	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	caggggaacgagtactccctCccagccctgacccctgggct	7	6	11	17	1	0	1	0	1	0	0	2	3	2	2	5	3	3	2	5	3	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:102568884C>G	uc001krk.3	+	8	1429	c.879C>G	c.(877-879)CTC>CTG	p.L293L	PAX2_uc001krl.3_Silent_p.L270L|PAX2_uc001krm.3_Silent_p.L293L|PAX2_uc001kro.3_Silent_p.L270L|PAX2_uc001krn.3_Silent_p.L270L|PAX2_uc010qps.1_Silent_p.L269L|PAX2_uc001krp.1_Silent_p.L266L	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	293					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		AGTACTCCCTCCCAGCCCTGA	0.567													30	75					0	0	0	0	G	102568884	G	G	102568884	2	3	303	1	0	0	0	0	0	0	0	1	11533	842	30	2		2	PAX2	10	102568884	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	900100	102568884	32965863	379	55906											
GPAM	57678	broad.mit.edu	37	chr10	113928115	113928115	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcgataatgcgatcataggaGattccaacaggtattatcaa	15	11	8	7	2	2	1	2	0	0	1	4	4	3	1	1	2	2	1	1	2	6	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:113928115G>C	uc009xxy.1	-	11	1260	c.1062C>G	c.(1060-1062)ATC>ATG	p.I354M	GPAM_uc001kzp.2_Missense_Mutation_p.I354M|GPAM_uc001kzq.1_Missense_Mutation_p.I354M	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	354					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		GATCATAGGAGATTCCAACAG	0.403													19	44					0	0	0	0	C	113928115	C	C	113928115	3	2	303	1	0	0	0	0	1	0	0	0	6626	932	33	2	1472	2	GPAM	10	113928115	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	11359231	113928115	21606632	380	55907											
NRAP	4892	broad.mit.edu	37	chr10	115364392	115364392	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctctgcagggcatgggctttCttggcccaggccatcttcag	5	11	12	13	0	4	0	1	0	3	0	4	0	4	0	2	4	1	3	2	4	0	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:115364392C>T	uc001laj.2	-	35	4367	c.4203G>A	c.(4201-4203)AAG>AAA	p.K1401K	NRAP_uc009xyb.2_Silent_p.K190K|NRAP_uc001lak.2_Silent_p.K1366K|NRAP_uc001lal.3_Silent_p.K1401K	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1401	Nebulin 37.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CATGGGCTTTCTTGGCCCAGG	0.577													11	31					0	0	0	0	T	115364392	T	T	115364392	2	4	303	1	0	0	0	0	0	0	0	1	10692	912	32	2		2	NRAP	10	115364392	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1436277	115364392	20170355	381	55908											
NRAP	4892	broad.mit.edu	37	chr10	115372035	115372035	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttggcacagctcagcctCaggtcttctgccaaggaagt	8	11	10	12	0	5	0	2	0	3	0	5	1	5	1	2	3	3	2	2	3	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:115372035C>T	uc001laj.2	-	30	3620	c.3456G>A	c.(3454-3456)CTG>CTA	p.L1152L	NRAP_uc009xyb.2_Intron|NRAP_uc001lak.2_Silent_p.L1117L|NRAP_uc001lal.3_Silent_p.L1152L	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1152	Nebulin 30.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		AGCTCAGCCTCAGGTCTTCTG	0.557													13	54					0	0	0	0	T	115372035	T	T	115372035	2	4	303	1	0	0	0	0	0	0	0	1	10692	813	29	2		2	NRAP	10	115372035	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	7643	115372035	20162712	382	55909											
AFAP1L2	84632	broad.mit.edu	37	chr10	116059062	116059062	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttagctcccgtttctctttCcggagctgagccaggtgccc	4	13	10	14	2	1	1	0	1	1	0	4	2	3	2	4	2	4	3	4	2	1	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:116059062C>G	uc001lbn.2	-	16	2371	c.2070G>C	c.(2068-2070)CGG>CGC	p.R690R	AFAP1L2_uc001lbo.2_Silent_p.R690R|AFAP1L2_uc010qse.1_Silent_p.R743R|AFAP1L2_uc001lbp.2_Silent_p.R718R|AFAP1L2_uc001lbr.1_Silent_p.R689R|AFAP1L2_uc001lbm.2_Silent_p.R129R|AFAP1L2_uc010qsd.1_Silent_p.R256R|AFAP1L2_uc001lbq.1_Silent_p.R212R	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	690	Potential.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GTTTCTCTTTCCGGAGCTGAG	0.562													14	39					0	0	0	0	G	116059062	G	G	116059062	2	3	303	1	0	0	0	0	0	0	0	1	355	842	30	2		2	AFAP1L2	10	116059062	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	687027	116059062	19475685	383	55910											
ABLIM1	3983	broad.mit.edu	37	chr10	116251568	116251568	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accttgaagatacatttcctCtccttctgtgaacatctggt	9	15	6	11	0	3	3	0	2	3	1	5	3	4	3	3	1	2	0	3	1	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:116251568C>G	uc010qsg.1	-	7	1063	c.964G>C	c.(964-966)GAG>CAG	p.E322Q	ABLIM1_uc010qsh.1_Missense_Mutation_p.E262Q|ABLIM1_uc010qsi.1_Missense_Mutation_p.E262Q|ABLIM1_uc010qsk.1_Missense_Mutation_p.E246Q|ABLIM1_uc009xyp.2_Missense_Mutation_p.E256Q|ABLIM1_uc010qsf.1_Missense_Mutation_p.E6Q|ABLIM1_uc009xyn.2_5'UTR|ABLIM1_uc010qsj.1_5'UTR|ABLIM1_uc009xyo.2_Missense_Mutation_p.E170Q	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	322	LIM zinc-binding 4.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		TACATTTCCTCTCCTTCTGTG	0.453													30	67					0	0	0	0	G	116251568	G	G	116251568	3	3	303	1	0	0	0	0	1	0	0	0	94	922	32	2	1524	2	ABLIM1	10	116251568	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	192506	116251568	19283179	384	55911											
FAM160B1	57700	broad.mit.edu	37	chr10	116620558	116620558	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgttatctagactttctctCttccctcatccacacatcca	8	15	3	15	0	4	1	1	0	3	1	8	1	7	1	3	0	0	1	3	0	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:116620558C>T	uc001lcb.2	+	15	2333	c.1998C>T	c.(1996-1998)CTC>CTT	p.L666L	FAM160B1_uc001lcc.2_Silent_p.L666L	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	666										lung(1)	1						GACTTTCTCTCTTCCCTCATC	0.398													47	99					0	0	0	0	T	116620558	T	T	116620558	2	4	303	1	0	0	0	0	0	0	0	1	5498	900	32	2		2	FAM160B1	10	116620558	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	368990	116620558	18914189	385	55912											
BTBD16	118663	broad.mit.edu	37	chr10	124050611	124050611	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccagccttcgccacggccctGaagaacctctacatgagtga	10	7	9	15	2	1	4	0	3	1	1	2	4	1	4	5	1	3	0	5	1	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:124050611G>A	uc001lgc.1	+	7	743	c.492G>A	c.(490-492)CTG>CTA	p.L164L	BTBD16_uc001lgd.1_Silent_p.L163L	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	164	BTB.									skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CCACGGCCCTGAAGAACCTCT	0.597													43	130					0	0	0	0	A	124050611	A	A	124050611	2	1	303	1	0	0	0	0	0	0	0	1	1546	1277	45	2		2	BTBD16	10	124050611	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7430053	124050611	11484136	386	55913											
CTBP2	1488	broad.mit.edu	37	chr10	126681792	126681792	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgtgatggctcggcggatctCggtggcagctgcctccctca	4	10	14	13	3	2	1	1	1	1	0	5	2	3	2	2	5	2	3	2	5	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:126681792C>T	uc009yak.2	-	9	1305	c.1018G>A	c.(1018-1020)GAG>AAG	p.E340K	CTBP2_uc009yal.2_Missense_Mutation_p.E340K|CTBP2_uc001lif.3_Missense_Mutation_p.E340K|CTBP2_uc001lih.3_Missense_Mutation_p.E340K|CTBP2_uc001lid.3_Missense_Mutation_p.E408K|CTBP2_uc001lie.3_Missense_Mutation_p.E880K	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	340					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CGGCGGATCTCGGTGGCAGCT	0.632													6	17					0	0	0	0	T	126681792	T	T	126681792	3	4	303	1	0	0	0	0	1	0	0	0	4015	893	31	1	331	1	CTBP2	10	126681792	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2631181	126681792	8852955	387	55914											
UROS	7390	broad.mit.edu	37	chr10	127503692	127503692	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtcccccgtaatcttcaggaTgagaaagctgcacaccaaaa	14	7	8	12	1	2	1	1	1	1	1	3	3	3	2	3	1	2	3	3	1	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:127503692T>A	uc001liw.3	-	3	288	c.155A>T	c.(154-156)CAT>CTT	p.H52L	UROS_uc001liv.3_5'UTR|UROS_uc010quh.1_RNA|UROS_uc001lix.3_Missense_Mutation_p.H52L|UROS_uc001liy.3_RNA|UROS_uc001liz.2_RNA	NM_000375	NP_000366	P10746	HEM4_HUMAN	uroporphyrinogen III synthase	52					heme biosynthetic process|uroporphyrinogen III biosynthetic process	cytosol|mitochondrion	uroporphyrinogen-III synthase activity				0		all_lung(145;0.00756)|Lung NSC(174;0.0116)|Colorectal(57;0.0855)|all_neural(114;0.0937)|Breast(234;0.203)				ATCTTCAGGATGAGAAAGCTG	0.428													6	17					0	0	0	0	A	127503692	A	A	127503692	3	1	303	1	0	0	0	0	1	0	0	0	17098	1464	51	5	670	5	UROS	10	127503692	Missense_Mutation	SNP	T	TCGA-HL-7533-01A-11D-2229-08	821900	127503692	8031055	388	55915											
DOCK1	1793	broad.mit.edu	37	chr10	128840976	128840976	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acacgttagtctttgatgctCtggtaagagagctttccttc	8	15	9	9	1	2	2	0	1	2	1	4	3	3	2	1	1	2	4	1	1	2	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr10:128840976C>G	uc001ljt.2	+	20	2099	c.2035C>G	c.(2035-2037)CTG>GTG	p.L679V	DOCK1_uc010qun.1_Missense_Mutation_p.L700V	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	679					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CTTTGATGCTCTGGTAAGAGA	0.488													26	45					0	0	0	0	G	128840976	G	G	128840976	3	3	303	1	0	0	0	0	1	0	0	0	4706	912	32	2	2113	2	DOCK1	10	128840976	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1337284	128840976	6693771	389	55916											
LRDD	55367	broad.mit.edu	37	chr11	802015	802015	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caggtcaccccagctgttgtCattccgggtcctgaccacca	7	9	9	16	1	2	1	2	1	0	0	4	1	4	1	6	2	1	2	6	2	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:802015C>T	uc001lro.1	-	7	1394	c.1252G>A	c.(1252-1254)GAC>AAC	p.D418N	LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.D418N|LRDD_uc001lrl.1_Missense_Mutation_p.D272N|LRDD_uc001lrm.1_Missense_Mutation_p.D105N|LRDD_uc001lrn.1_Missense_Mutation_p.D272N|LRDD_uc001lrp.1_5'UTR	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	418	ZU5 1.				apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAGCTGTTGTCATTCCGGGTC	0.662													9	14					0	0	0	0	T	802015	T	T	802015	3	4	303	1	0	0	0	0	1	0	0	0	8986	826	29	2	1520	2	LRDD	11	802015	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08		802015	134204501	390	55917											
RPLP2	6181	broad.mit.edu	37	chr11	812802	812802	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaggaggagtctgaagagtCagatgatgacatgggatttg	13	9	16	3	0	2	5	1	3	1	2	2	9	2	8	0	3	0	0	0	3	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:812802C>G	uc001lrq.1	+	5	419	c.314C>G	c.(313-315)TCA>TGA	p.S105*	RPLP2_uc001lrr.1_Nonsense_Mutation_p.S105*	NM_001004	NP_000995	P05387	RLA2_HUMAN	ribosomal protein P2	105					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCTGAAGAGTCAGATGATGAC	0.478													10	27					0	0	0	0	G	812802	G	G	812802	4	3	303	1	0	0	0	0	0	1	0	0	13671	838	29	2	328	2	RPLP2	11	812802	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	10787	812802	134193714	391	55918											
OR52I1	390037	broad.mit.edu	37	chr11	4616129	4616129	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctagctgacctgtacgtgatCatcccagccactttaaatcc	10	11	6	14	1	1	2	1	2	0	0	3	2	3	2	4	0	3	2	4	0	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:4616129C>T	uc010qyi.1	+	1	861	c.861C>T	c.(859-861)ATC>ATT	p.I287I		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTACGTGATCATCCCAGCCA	0.498													37	103					0	0	0	0	T	4616129	T	T	4616129	2	4	303	1	0	0	0	0	0	0	0	1	11174	816	29	2		2	OR52I1	11	4616129	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3803327	4616129	130390387	392	55919											
OR10A4	283297	broad.mit.edu	37	chr11	6898070	6898070	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtcctatgtacttcttcctCagaaacttgtccttcctgga	8	15	6	12	0	2	1	1	0	1	1	6	2	6	2	4	1	2	1	4	1	3	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:6898070C>T	uc010rat.1	+	1	192	c.192C>T	c.(190-192)CTC>CTT	p.L64L		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ACTTCTTCCTCAGAAACTTGT	0.438													38	91					0	0	0	0	T	6898070	T	T	6898070	2	4	303	1	0	0	0	0	0	0	0	1	10946	813	29	2		2	OR10A4	11	6898070	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2281941	6898070	128108446	393	55920											
OR5P3	120066	broad.mit.edu	37	chr11	7846617	7846617	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttattctaagctctctcttCagagcccccttaatctcctt	7	17	3	14	0	5	1	1	0	4	1	7	1	5	1	3	0	2	1	3	0	3	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:7846617C>T	uc010rbg.1	-	1	903	c.903G>A	c.(901-903)CTG>CTA	p.L301L		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCTCTCTCTTCAGAGCCCCCT	0.373													15	17					0	0	0	0	T	7846617	T	T	7846617	2	4	303	1	0	0	0	0	0	0	0	1	11233	813	29	2		2	OR5P3	11	7846617	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	948547	7846617	127159899	394	55921											
OR5P3	120066	broad.mit.edu	37	chr11	7846842	7846842	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccttggtggagtgcatcttCaggatggtgatgaggatata	9	12	14	6	0	2	2	1	2	1	0	2	5	2	5	1	5	1	1	1	5	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:7846842C>T	uc010rbg.1	-	1	678	c.678G>A	c.(676-678)CTG>CTA	p.L226L		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGTGCATCTTCAGGATGGTGA	0.468													21	38					0	0	0	0	T	7846842	T	T	7846842	2	4	303	1	0	0	0	0	0	0	0	1	11233	813	29	2		2	OR5P3	11	7846842	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	225	7846842	127159674	395	55922											
DBX1	120237	broad.mit.edu	37	chr11	20178090	20178090	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccttggagttccgccatttCatgcgtcggttctggaacca	6	13	10	12	3	2	0	1	0	1	0	5	2	4	2	4	3	2	2	4	3	1	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:20178090C>T	uc001mpw.1	-	4	819	c.819G>A	c.(817-819)ATG>ATA	p.M273I		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	234	Homeobox.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCCGCCATTTCATGCGTCGGT	0.637													19	36					0	0	0	0	T	20178090	T	T	20178090	3	4	303	1	0	0	0	0	1	0	0	0	4276	826	29	2	333	2	DBX1	11	20178090	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	12331248	20178090	114828426	396	55923											
ANO5	203859	broad.mit.edu	37	chr11	22261169	22261169	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctaccaatgaaagatacacaCttcaccagaattgggctcga	15	8	7	11	1	1	3	1	1	0	2	2	4	1	3	2	1	2	1	2	1	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:22261169C>T	uc001mqi.2	+	9	1134	c.817C>T	c.(817-819)CTT>TTT	p.L273F	ANO5_uc001mqj.2_Missense_Mutation_p.L272F	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	273	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						AAGATACACACTTCACCAGAA	0.403													25	64					0	0	0	0	T	22261169	T	T	22261169	3	4	303	1	0	0	0	0	1	0	0	0	700	565	20	4	851	4	ANO5	11	22261169	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2083079	22261169	112745347	397	55924											
RTN4RL2	349667	broad.mit.edu	37	chr11	57235412	57235412	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgacaaccggcacctgcgctCgctggagcccgacaccttcc	7	6	10	18	4	0	1	0	1	0	0	2	3	1	2	5	2	3	3	5	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:57235412C>G	uc010rjt.1	+	2	362	c.362C>G	c.(361-363)TCG>TGG	p.S121W		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	121	LRR 3.				axon regeneration	anchored to plasma membrane	receptor activity				0						CACCTGCGCTCGCTGGAGCCC	0.647													28	66					0	0	0	0	G	57235412	G	G	57235412	3	3	303	1	0	0	0	0	1	0	0	0	13797	893	31	3	368	3	RTN4RL2	11	57235412	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	34974243	57235412	77771104	398	55925											
OR10Q1	219960	broad.mit.edu	37	chr11	57995911	57995911	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggccccacccagcatctgcGtgcacagctcgcgggtcatg	6	6	13	16	3	2	0	1	0	1	0	3	0	2	0	3	2	4	3	3	2	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:57995911G>A	uc010rkd.1	-	1	437	c.437C>T	c.(436-438)ACG>ATG	p.T146M		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				CAGCATCTGCGTGCACAGCTC	0.617													6	17					0	0	0	0	A	57995911	A	A	57995911	3	1	303	1	0	0	0	0	1	0	0	0	10970	1145	40	1	526	1	OR10Q1	11	57995911	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	760499	57995911	77010605	399	55926											
OR5B21	219968	broad.mit.edu	37	chr11	58275483	58275483	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaagcagggtgatgaggtaGatgaataaaaatgccaggag	16	6	14	5	0	0	4	0	3	0	1	0	5	0	5	2	3	2	2	2	3	6	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:58275483G>C	uc010rki.1	-	1	96	c.96C>G	c.(94-96)ATC>ATG	p.I32M		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGATGAGGTAGATGAATAAAA	0.468													17	77					0	0	0	0	C	58275483	C	C	58275483	3	2	303	1	0	0	0	0	1	0	0	0	11205	932	33	2	835	2	OR5B21	11	58275483	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	279572	58275483	76731033	400	55927											
PRPF19	27339	broad.mit.edu	37	chr11	60658681	60658681	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtccatgcctgttgaaGcgatgaacttggcgtgatgc	7	13	12	9	2	1	3	0	3	1	0	2	4	2	3	2	1	4	1	2	1	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:60658681G>A	uc001nqf.2	-	16	1679	c.1472C>T	c.(1471-1473)GCT>GTT	p.A491V		NM_014502	NP_055317	Q9UMS4	PRP19_HUMAN	PRP19/PSO4 pre-mRNA processing factor 19	491	WD 7.				DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						GCCTGTTGAAGCGATGAACTT	0.547													10	29					0	0	0	0	A	60658681	A	A	60658681	3	1	303	1	0	0	0	0	1	0	0	0	12626	971	34	4	46	4	PRPF19	11	60658681	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2383198	60658681	74347835	401	55928											
ESRRA	2101	broad.mit.edu	37	chr11	64082613	64082613	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggacttagtcctggatgaaGagggggcacgggcagctggc	9	6	18	8	1	0	2	0	1	0	1	1	4	1	4	1	6	1	3	1	6	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:64082613G>C	uc001nzq.1	+	6	1060	c.883G>C	c.(883-885)GAG>CAG	p.E295Q	ESRRA_uc001nzr.1_Missense_Mutation_p.E294Q|ESRRA_uc001nzs.1_Missense_Mutation_p.E295Q|ESRRA_uc009ypn.1_RNA|PRDX5_uc001nzu.2_5'Flank|PRDX5_uc001nzv.2_5'Flank|PRDX5_uc001nzw.2_5'Flank	NM_004451	NP_004442	P11474	ERR1_HUMAN	estrogen-related receptor alpha	295	Ligand binding domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0						CCTGGATGAAGAGGGGGCACG	0.662													10	31					0	0	0	0	C	64082613	C	C	64082613	3	2	303	1	0	0	0	0	1	0	0	0	5284	943	33	2	901	2	ESRRA	11	64082613	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3423932	64082613	70923903	402	55929											
CCDC88B	283234	broad.mit.edu	37	chr11	64108793	64108793	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcggctactgttgggagcgtCagtacaggtgagccggcggt	6	9	17	9	4	1	1	1	1	0	0	2	2	1	2	1	5	4	3	1	5	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:64108793C>T	uc001nzy.2	+	5	484	c.440C>T	c.(439-441)TCA>TTA	p.S147L	CCDC88B_uc009ypo.1_Missense_Mutation_p.S144L|CCDC88B_uc001nzz.1_5'Flank	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	147					microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						TTGGGAGCGTCAGTACAGGTG	0.602													23	52					0	0	0	0	T	64108793	T	T	64108793	3	4	303	1	0	0	0	0	1	0	0	0	2877	838	29	2	458	2	CCDC88B	11	64108793	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	26180	64108793	70897723	403	55930											
RASGRP2	10235	broad.mit.edu	37	chr11	64510276	64510276	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agccactcaccgaaggcttcGatgcacccgcggagcagctc	9	5	11	16	4	1	0	1	0	0	0	3	3	1	1	3	2	4	4	3	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:64510276G>A	uc009ypu.2	-	2	290	c.63C>T	c.(61-63)ATC>ATT	p.I21I	RASGRP2_uc001oat.2_5'Flank|RASGRP2_uc001oau.2_5'Flank|RASGRP2_uc009ypv.2_Silent_p.I21I|RASGRP2_uc009ypw.2_Silent_p.I21I|RASGRP2_uc001oaw.1_Missense_Mutation_p.S324L	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	21	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						CGAAGGCTTCGATGCACCCGC	0.726													9	16					0	0	0	0	A	64510276	A	A	64510276	2	1	303	1	0	0	0	0	0	0	0	1	13140	1048	37	1		1	RASGRP2	11	64510276	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	401483	64510276	70496240	404	55931											
LTBP3	4054	broad.mit.edu	37	chr11	65319844	65319844	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctcagggctcaccaggCggaaacacaggctcttctcc	8	7	12	14	1	4	0	2	0	2	0	5	1	4	1	2	5	2	3	2	5	1	1	rs147206443		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:65319844C>T	uc001oej.2	-	7	1489	c.1220G>A	c.(1219-1221)CGC>CAC	p.R407H	LTBP3_uc010roi.1_Missense_Mutation_p.R290H|LTBP3_uc001oei.2_Missense_Mutation_p.R407H|LTBP3_uc010roj.1_Missense_Mutation_p.R108H|LTBP3_uc010rok.1_Missense_Mutation_p.R318H	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	407	TB 2.					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						GCTCACCAGGCGGAAACACAG	0.677											OREG0021081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	63					0	0	0	0	T	65319844	T	T	65319844	3	4	303	1	0	0	0	0	1	0	0	0	9125	768	27	1	2779	1	LTBP3	11	65319844	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	809568	65319844	69686672	405	55932											
KAT5	10524	broad.mit.edu	37	chr11	65486586	65486586	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgggccatgctcaagcggctCctgcggatcgactccaagtg	7	7	13	14	4	1	0	1	0	0	0	4	2	3	1	3	3	3	2	3	3	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:65486586C>G	uc001ofi.2	+	14	1726	c.1476C>G	c.(1474-1476)CTC>CTG	p.L492L	KAT5_uc001ofj.2_Silent_p.L440L|KAT5_uc001ofk.2_Silent_p.L525L|KAT5_uc010roo.1_Silent_p.L473L|KAT5_uc001ofl.2_Silent_p.L281L|RNASEH2C_uc001ofm.2_RNA|RNASEH2C_uc001ofn.2_3'UTR	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	492					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						TCAAGCGGCTCCTGCGGATCG	0.607													15	28					0	0	0	0	G	65486586	G	G	65486586	2	3	303	1	0	0	0	0	0	0	0	1	8022	842	30	2		2	KAT5	11	65486586	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	166742	65486586	69519930	406	55933											
CORO1B	57175	broad.mit.edu	37	chr11	67209950	67209950	+	Silent	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctccactggcctccacaatCaccgccaggaacttggggtt	8	8	9	16	1	1	0	1	0	0	0	3	1	3	1	6	4	1	1	6	4	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:67209950C>A	uc001olj.1	-	1	186	c.150G>T	c.(148-150)GTG>GTT	p.V50V	CORO1B_uc009yrs.1_RNA|CORO1B_uc001olk.1_Silent_p.V50V|CORO1B_uc009yrt.1_RNA|CORO1B_uc009yru.1_RNA|CORO1B_uc001oll.1_Silent_p.V50V|CORO1B_uc010rps.1_Silent_p.V50V|CORO1B_uc009yrv.1_Silent_p.V50V	NM_020441	NP_065174	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	50					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CCTCCACAATCACCGCCAGGA	0.627													13	35					3.41278e-10	3.50869e-10	1	0	A	67209950	A	A	67209950	2	1	303	1	0	0	0	0	0	0	0	1	3769	813	29	2		2	CORO1B	11	67209950	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1723364	67209950	67796566	407	55934											
PITPNM1	9600	broad.mit.edu	37	chr11	67266171	67266171	+	Missense_Mutation	SNP	G	T	T																															tggatgcgggtgacggcctcGaaggcggagctcagcgtctg																								rs115377785	byFrequency	TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:67266171G>T	uc001olx.2	-	9	1569	c.1380C>A	c.(1378-1380)TTC>TTA	p.F460L	PITPNM1_uc001olw.2_5'Flank|PITPNM1_uc001oly.2_Missense_Mutation_p.F460L|PITPNM1_uc001olz.2_Missense_Mutation_p.F460L	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	460					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						TGACGGCCTCGAAGGCGGAGC	0.657													18	57					6.49762e-13	6.71956e-13	1	0	T	67266171	T	T	67266171	3	4	303	1	0	0	0	0	1	0	0	0	12005	1049	37	3	2414	3	PITPNM1	11	67266171	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	56221	67266171	67740345	408	55935	133	2									
PITPNM1	9600	broad.mit.edu	37	chr11	67266178	67266178	+	Missense_Mutation	SNP	G	A	A																															gggtgacggcctcgaaggcgGagctcagcgtctgcacatcc																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:67266178G>A	uc001olx.2	-	9	1562	c.1373C>T	c.(1372-1374)TCC>TTC	p.S458F	PITPNM1_uc001olw.2_5'Flank|PITPNM1_uc001oly.2_Missense_Mutation_p.S458F|PITPNM1_uc001olz.2_Missense_Mutation_p.S458F	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	458					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						CTCGAAGGCGGAGCTCAGCGT	0.667													17	52					0	0	0	0	A	67266178	A	A	67266178	3	1	303	1	0	0	0	0	1	0	0	0	12005	1174	41	2	2421	2	PITPNM1	11	67266178	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7	67266178	67740338	409	55936	133	2									
NUDT8	254552	broad.mit.edu	37	chr11	67395432	67395432	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgtcaaagacctttattCagtcctggagtggagctggc	9	11	12	9	0	2	1	2	0	0	1	3	3	3	3	2	3	2	2	2	3	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:67395432C>T	uc001omo.1	-	4	715	c.696G>A	c.(694-696)CTG>CTA	p.L232L	NUDT8_uc001omn.2_3'UTR	NM_181843	NP_862826	Q8WV74	NUDT8_HUMAN	nudix-type motif 8	232						mitochondrion	hydrolase activity|metal ion binding				0						GACCTTTATTCAGTCCTGGAG	0.642													9	15					0	0	0	0	T	67395432	T	T	67395432	2	4	303	1	0	0	0	0	0	0	0	1	10799	841	29	2		2	NUDT8	11	67395432	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	129254	67395432	67611084	410	55937											
TCIRG1	10312	broad.mit.edu	37	chr11	67808853	67808853	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgggcctcgtggagttcagaGacgtgagttgggtgggcagg	6	9	20	6	2	1	2	1	1	0	1	2	4	1	3	1	5	0	3	1	5	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:67808853G>C	uc001one.2	+	2	223	c.115G>C	c.(115-117)GAC>CAC	p.D39H	TCIRG1_uc001ond.1_Missense_Mutation_p.D39H|TCIRG1_uc001onf.1_Missense_Mutation_p.D39H|TCIRG1_uc001ong.2_5'Flank|TCIRG1_uc001onh.2_5'Flank|TCIRG1_uc001oni.2_5'Flank	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	39	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						GGAGTTCAGAGACGTGAGTTG	0.692													13	60					0	0	0	0	C	67808853	C	C	67808853	3	2	303	1	0	0	0	0	1	0	0	0	15769	942	33	2	117	2	TCIRG1	11	67808853	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	413421	67808853	67197663	411	55938											
FAM86C	55199	broad.mit.edu	37	chr11	71510692	71510692	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacttggagatggcaaagctGaacctcacactgtaggactc	12	8	10	11	0	1	2	1	1	0	1	2	4	1	3	1	3	2	3	1	3	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:71510692G>A	uc001oqv.3	+	5	523	c.497G>A	c.(496-498)TGA>TAA	p.*166*	FAM86C_uc009ysr.2_Silent_p.*159*|FAM86C_uc001oqw.3_Silent_p.*132*|FAM86C_uc009yss.2_RNA|FAM86C_uc010rqq.1_RNA|uc001oqx.1_Intron	NM_018172	NP_060642	Q9NVL1	FA86C_HUMAN	hypothetical protein LOC55199 isoform 1	166											0						TGGCAAAGCTGAACCTCACAC	0.468													23	58					0	0	0	0	A	71510692	A	A	71510692	2	1	303	1	0	0	0	0	0	0	0	1	5678	1285	45	2		2	FAM86C	11	71510692	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3701839	71510692	63495824	412	55939											
C2CD3	26005	broad.mit.edu	37	chr11	73795939	73795939	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccttaccagatctcttgatCagcagctcttttgttggaac	8	15	7	11	0	3	2	1	1	2	1	5	3	4	3	2	1	4	3	2	1	2	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:73795939C>T	uc001ouu.2	-	22	4214	c.3987G>A	c.(3985-3987)CTG>CTA	p.L1329L	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1329						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					ATCTCTTGATCAGCAGCTCTT	0.388													11	17					0	0	0	0	T	73795939	T	T	73795939	2	4	303	1	0	0	0	0	0	0	0	1	2164	813	29	2		2	C2CD3	11	73795939	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2285247	73795939	61210577	413	55940											
DYNC2H1	79659	broad.mit.edu	37	chr11	103060496	103060496	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcattctatttggggttcttCatcaaaaatttatcttttag	10	20	5	6	0	6	0	3	0	3	0	6	0	6	0	0	2	0	1	0	2	5	9			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:103060496C>T	uc001pho.2	+	45	7532	c.7388C>T	c.(7387-7389)TCA>TTA	p.S2463L	DYNC2H1_uc001phn.1_Missense_Mutation_p.S2463L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2463	AAA 3 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TGGGGTTCTTCATCAAAAATT	0.318													15	22					0	0	0	0	T	103060496	T	T	103060496	3	4	303	1	0	0	0	0	1	0	0	0	4868	838	29	2	7566	2	DYNC2H1	11	103060496	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	29264557	103060496	31946020	414	55941											
ARHGEF12	23365	broad.mit.edu	37	chr11	120312464	120312464	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcattgaattactaaaatctCgcccggctcatttggctgtt	9	14	8	10	2	2	1	1	1	1	0	3	1	2	1	1	2	1	4	1	2	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:120312464C>T	uc001pxl.1	+	14	1148	c.1141C>T	c.(1141-1143)CGC>TGC	p.R381C	ARHGEF12_uc009zat.2_Missense_Mutation_p.R362C|ARHGEF12_uc010rzn.1_Missense_Mutation_p.R278C|ARHGEF12_uc009zau.1_Missense_Mutation_p.R278C	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	381	RGSL.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ACTAAAATCTCGCCCGGCTCA	0.373			T	MLL	AML								29	46					0	0	0	0	T	120312464	T	T	120312464	3	4	303	1	0	0	0	0	1	0	0	0	897	884	31	1	1195	1	ARHGEF12	11	120312464	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	17251968	120312464	14694052	415	55942											
ARHGAP32	9743	broad.mit.edu	37	chr11	128933836	128933836	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggggcccgagcagtgtacctCttgataacatgggcagcacc	9	7	13	12	1	1	1	0	1	1	0	1	2	1	1	3	3	4	4	3	3	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr11:128933836C>G	uc009zcp.2	-	8	804	c.804G>C	c.(802-804)AAG>AAC	p.K268N	ARHGAP32_uc009zcq.1_Missense_Mutation_p.K228N|ARHGAP32_uc001qfb.2_Missense_Mutation_p.K53N	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	268	SH3.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						CAGTGTACCTCTTGATAACAT	0.428													43	51					0	0	0	0	G	128933836	G	G	128933836	3	3	303	1	0	0	0	0	1	0	0	0	881	912	32	2	5519	2	ARHGAP32	11	128933836	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	8621372	128933836	6072680	416	55943											
CACNA1C	775	broad.mit.edu	37	chr12	2797906	2797906	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agccaggctggggccccaggGaggcagttccacggcagtgc	7	4	17	13	1	0	0	0	0	0	0	1	1	1	1	4	6	2	4	4	6	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:2797906G>A	uc009zdu.1	+	49	6640	c.6327G>A	c.(6325-6327)GGG>GGA	p.G2109G	CACNA1C_uc009zdv.1_Silent_p.G2023G|CACNA1C_uc001qkb.2_Silent_p.G2026G|CACNA1C_uc001qkc.2_Silent_p.G2045G|CACNA1C_uc001qke.2_Silent_p.G2015G|CACNA1C_uc001qkf.2_Silent_p.G2034G|CACNA1C_uc001qjz.2_Silent_p.G2026G|CACNA1C_uc001qkd.2_Silent_p.G2045G|CACNA1C_uc001qkg.2_Silent_p.G2032G|CACNA1C_uc009zdw.1_Silent_p.G2067G|CACNA1C_uc001qkh.2_Silent_p.G2034G|CACNA1C_uc001qkl.2_Silent_p.G2074G|CACNA1C_uc001qkn.2_Silent_p.G2026G|CACNA1C_uc001qko.2_Silent_p.G2046G|CACNA1C_uc001qkp.2_Silent_p.G2026G|CACNA1C_uc001qkr.2_Silent_p.G2043G|CACNA1C_uc001qku.2_Silent_p.G2061G|CACNA1C_uc001qkq.2_Silent_p.G2054G|CACNA1C_uc001qks.2_Silent_p.G2026G|CACNA1C_uc001qkt.2_Silent_p.G2045G|CACNA1C_uc001qki.1_Silent_p.G1833G|CACNA1C_uc001qkj.1_Silent_p.G1797G|CACNA1C_uc001qkk.1_Silent_p.G1762G|CACNA1C_uc001qkm.1_Silent_p.G1822G|CACNA1C_uc010sea.1_Silent_p.G717G|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Silent_p.G344G	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	2109	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGGCCCCAGGGAGGCAGTTCC	0.721													4	6					0	0	0	0	A	2797906	A	A	2797906	2	1	303	1	0	0	0	0	0	0	0	1	2552	1161	41	2		2	CACNA1C	12	2797906	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08		2797906	131053989	417	55944											
SCNN1A	6337	broad.mit.edu	37	chr12	6457040	6457040	+	Nonstop_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agaaacctctccttccctctCagggcccccccagaggacag	9	6	8	18	0	2	2	1	0	2	2	5	3	3	3	6	2	1	0	6	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:6457040C>G	uc001qnx.2	-	13	2298	c.2009G>C	c.(2008-2010)TGA>TCA	p.*670S	SCNN1A_uc001qnv.2_Nonstop_Mutation_p.*370S|SCNN1A_uc001qnw.2_Nonstop_Mutation_p.*729S|SCNN1A_uc010sfb.1_Nonstop_Mutation_p.*693S	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	670					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	CCTTCCCTCTCAGGGCCCCCC	0.488													3	10					0	0	0	0	G	6457040	G	G	6457040	4	3	303	1	0	0	0	0	0	0	0	0	13992	837	29	2	4	2	SCNN1A	12	6457040	Nonstop_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3659134	6457040	127394855	418	55945											
LRRC23	10233	broad.mit.edu	37	chr12	7022144	7022144	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ctgagccccagcgtgacctgGaacccgaacagtcattgatc	10	7	10	14	2	1	3	1	3	0	0	2	5	1	4	4	1	4	0	4	1	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:7022144G>A	uc001qrt.3	+	7	1401	c.1009G>A	c.(1009-1011)GAA>AAA	p.E337K	LRRC23_uc001qrp.2_Missense_Mutation_p.E337K|LRRC23_uc001qrq.2_Intron|LRRC23_uc001qrr.2_Missense_Mutation_p.E286K|LRRC23_uc001qrs.2_Intron|LRRC23_uc009zfh.2_Intron|ENO2_uc001qru.1_5'Flank|ENO2_uc009zfi.1_5'Flank|ENO2_uc010sfq.1_5'Flank|ENO2_uc001qrv.1_5'Flank	NM_001135217	NP_001128689	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23 isoform a	337										ovary(1)	1						GCGTGACCTGGAACCCGAACA	0.557													51	124					0	0	0	0	A	7022144	A	A	7022144	3	1	303	1	0	0	0	0	1	0	0	0	9028	1175	41	2	1031	2	LRRC23	12	7022144	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	565104	7022144	126829751	419	55946											
C1S	716	broad.mit.edu	37	chr12	7177493	7177493	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gacattgcactggtgcggctGaaagacccagtgaaaatggg	12	7	14	8	1	0	3	0	2	0	1	0	4	0	3	1	3	2	2	1	3	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:7177493G>A	uc001qsj.2	+	15	2324	c.1605G>A	c.(1603-1605)CTG>CTA	p.L535L	C1S_uc001qsk.2_Silent_p.L535L|C1S_uc001qsl.2_Silent_p.L535L|C1S_uc009zfr.2_Silent_p.L368L|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	535	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TGGTGCGGCTGAAAGACCCAG	0.527													10	18					0	0	0	0	A	7177493	A	A	7177493	2	1	303	1	0	0	0	0	0	0	0	1	1983	1277	45	2		2	C1S	12	7177493	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	155349	7177493	126674402	420	55947											
CD163L1	283316	broad.mit.edu	37	chr12	7525937	7525937	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttcacatgtgatccaggtctCttctgctgggctggagattc	6	14	11	10	0	3	2	1	1	2	1	6	3	4	2	1	3	1	2	1	3	0	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:7525937C>G	uc001qsy.2	-	14	3735	c.3709G>C	c.(3709-3711)GAG>CAG	p.E1237Q	CD163L1_uc010sge.1_Missense_Mutation_p.E1247Q	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1237	SRCR 11.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ATCCAGGTCTCTTCTGCTGGG	0.458													23	37					0	0	0	0	G	7525937	G	G	7525937	3	3	303	1	0	0	0	0	1	0	0	0	2983	922	32	2	676	2	CD163L1	12	7525937	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	348444	7525937	126325958	421	55948											
GUCY2C	2984	broad.mit.edu	37	chr12	14773978	14773978	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatgctcaactccataccaGagtgaactccaatgcgaatc	14	8	7	12	1	1	3	1	1	0	2	4	4	3	3	3	0	5	1	3	0	5	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:14773978G>C	uc001rcd.2	-	23	2911	c.2774C>G	c.(2773-2775)TCT>TGT	p.S925C		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	925	Cytoplasmic (Potential).|Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						CTCCATACCAGAGTGAACTCC	0.468													8	11					0	0	0	0	C	14773978	C	C	14773978	3	2	303	1	0	0	0	0	1	0	0	0	6935	942	33	2	467	2	GUCY2C	12	14773978	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7248041	14773978	119077917	422	55949											
ABCC9	10060	broad.mit.edu	37	chr12	21998612	21998612	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caatagtctatagctacaatGaccgaatgcttcaaaagctt	15	11	6	9	1	2	1	1	1	1	0	2	2	2	1	1	0	4	3	1	0	9	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:21998612G>A	uc001rfi.1	-	24	3041	c.3021C>T	c.(3019-3021)GTC>GTT	p.V1007V	ABCC9_uc001rfh.2_Silent_p.V1007V|ABCC9_uc001rfj.1_Silent_p.V971V	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1007	Helical; Name=12; (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TAGCTACAATGACCGAATGCT	0.428													14	26					0	0	0	0	A	21998612	A	A	21998612	2	1	303	1	0	0	0	0	0	0	0	1	59	1277	45	2		2	ABCC9	12	21998612	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7224634	21998612	111853283	423	55950											
PPFIBP1	8496	broad.mit.edu	37	chr12	27824475	27824475	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agccagagacttcatttgaaGaaaagtatgtcatttattaa	16	13	7	5	0	2	3	2	1	0	2	2	4	2	3	1	0	1	1	1	0	6	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:27824475G>A	uc001ric.1	+	14	1686	c.1309G>A	c.(1309-1311)GAA>AAA	p.E437K	PPFIBP1_uc010sjr.1_Missense_Mutation_p.E268K|PPFIBP1_uc001rib.1_Missense_Mutation_p.E420K|PPFIBP1_uc001ria.2_Missense_Mutation_p.E406K|PPFIBP1_uc001rid.1_Missense_Mutation_p.E284K	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	437					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					TTCATTTGAAGAAAAGTATGT	0.333													7	24					0	0	0	0	A	27824475	A	A	27824475	3	1	303	1	0	0	0	0	1	0	0	0	12368	943	33	2	1346	2	PPFIBP1	12	27824475	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5825863	27824475	106027420	424	55951											
DDX11	1663	broad.mit.edu	37	chr12	31253968	31253968	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tggctcttaccaggtcacgtGatccctccagacaacatcct	9	10	7	15	1	2	2	1	1	1	1	5	2	5	2	4	2	2	1	4	2	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:31253968G>C	uc001rjt.1	+	20	2207	c.1956G>C	c.(1954-1956)GTG>GTC	p.V652V	DDX11_uc001rjr.1_Silent_p.V652V|DDX11_uc001rjs.1_Silent_p.V652V|DDX11_uc001rju.1_Intron|DDX11_uc001rjv.1_Silent_p.V652V|DDX11_uc001rjw.1_Silent_p.V626V|DDX11_uc009zjn.1_RNA|DDX11_uc009zjo.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	652					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CAGGTCACGTGATCCCTCCAG	0.577										Multiple Myeloma(12;0.14)			35	124					0	0	0	0	C	31253968	C	C	31253968	2	2	303	1	0	0	0	0	0	0	0	1	4360	1277	45	2		2	DDX11	12	31253968	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3429493	31253968	102597927	425	55952											
DENND5B	160518	broad.mit.edu	37	chr12	31545220	31545220	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctatgaagtcccagatgaaGacattcttgtgaaagatgcg	13	10	10	8	1	1	6	0	3	1	3	2	6	2	6	2	0	1	0	2	0	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:31545220G>C	uc001rki.1	-	19	3633	c.3447C>G	c.(3445-3447)GTC>GTG	p.V1149V	DENND5B_uc001rkh.1_Silent_p.V1184V|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1149	RUN 2.			V -> A (in Ref. 1; BAC04583).		integral to membrane				ovary(1)|central_nervous_system(1)	2						CCCAGATGAAGACATTCTTGT	0.443													6	16					0	0	0	0	C	31545220	C	C	31545220	2	2	303	1	0	0	0	0	0	0	0	1	4459	929	33	2		2	DENND5B	12	31545220	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	291252	31545220	102306675	426	55953											
IRAK4	51135	broad.mit.edu	37	chr12	44180229	44180229	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttaaagaagaaattgaagatGaagaaaagacaattgaagat	23	8	9	1	0	0	9	0	3	0	6	0	9	0	9	0	0	0	0	0	0	10	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:44180229G>A	uc001rnu.3	+	12	1346	c.1216G>A	c.(1216-1218)GAA>AAA	p.E406K	IRAK4_uc001rnt.3_Missense_Mutation_p.E406K|IRAK4_uc001rnx.3_Missense_Mutation_p.E282K|IRAK4_uc001rny.3_Missense_Mutation_p.E282K|IRAK4_uc010sky.1_Missense_Mutation_p.E282K|IRAK4_uc001rnv.3_Missense_Mutation_p.E282K|IRAK4_uc001rnw.3_Missense_Mutation_p.E282K	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	406	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		AATTGAAGATGAAGAAAAGAC	0.269													9	20					0	0	0	0	A	44180229	A	A	44180229	3	1	303	1	0	0	0	0	1	0	0	0	7864	1291	45	2	1254	2	IRAK4	12	44180229	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	12635009	44180229	89671666	427	55954											
SFRS2IP	9169	broad.mit.edu	37	chr12	46328004	46328004	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attctccagagtggctaacaGaagaaaacatattggagaaa	18	8	9	6	0	1	4	0	0	1	4	2	5	1	4	1	2	2	1	1	2	6	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:46328004G>A	uc001rox.2	-	8	874	c.587C>T	c.(586-588)TCT>TTT	p.S196F	SFRS2IP_uc001roy.1_Missense_Mutation_p.S270F	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	196					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		GTGGCTAACAGAAGAAAACAT	0.299													6	10					0	0	0	0	A	46328004	A	A	46328004	3	1	303	1	0	0	0	0	1	0	0	0	14242	942	33	2	3836	2	SFRS2IP	12	46328004	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2147775	46328004	87523891	428	55955											
WNT10B	7480	broad.mit.edu	37	chr12	49364240	49364240	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacaaggggaactgctcaccGactgcacaacgccaggaaca	14	3	11	13	2	1	0	1	0	0	0	1	4	1	2	2	3	5	2	2	3	4	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:49364240G>A	uc001rss.2	-	2	419	c.73C>T	c.(73-75)CGG>TGG	p.R25W	WNT10B_uc001rst.2_Missense_Mutation_p.R25W	NM_003394	NP_003385	O00744	WN10B_HUMAN	wingless-type MMTV integration site family,	25					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			skin(4)|lung(3)	7						ACTGCTCACCGACTGCACAAC	0.687													8	12					0	0	0	0	A	49364240	A	A	49364240	3	1	303	1	0	0	0	0	1	0	0	0	17451	1072	37	1	1112	1	WNT10B	12	49364240	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3036236	49364240	84487655	429	55956											
NCKAP5L	57701	broad.mit.edu	37	chr12	50195635	50195635	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gagcgcagatgcctacctgaGggagcgagcctgtcgtgagc	8	6	16	11	3	0	3	0	2	0	1	1	6	0	4	3	1	6	1	3	1	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:50195635G>A	uc009zlk.2	-	6	549	c.347C>T	c.(346-348)CCT>CTT	p.P116L		NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	112	Pro-rich.									central_nervous_system(1)	1						GCCTACCTGAGGGAGCGAGCC	0.582													12	40					0	0	0	0	A	50195635	A	A	50195635	3	1	303	1	0	0	0	0	1	0	0	0	10278	1000	35	4	3689	4	NCKAP5L	12	50195635	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	831395	50195635	83656260	430	55957											
BCDIN3D	144233	broad.mit.edu	37	chr12	50232622	50232622	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accttccgggtcctttgattCatgaagtccagggtgataaa	10	12	10	9	1	1	3	1	3	0	0	4	3	4	3	4	2	0	0	4	2	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:50232622C>T	uc001rvh.2	-	2	453	c.411G>A	c.(409-411)ATG>ATA	p.M137I	LOC100286844_uc010smm.1_Intron|LOC100286844_uc001rvg.2_RNA|LOC100286844_uc010smn.1_RNA	NM_181708	NP_859059	Q7Z5W3	BN3D2_HUMAN	BCDIN3 domain containing	137	Bin3-type SAM.						methyltransferase activity			ovary(1)	1						TCCTTTGATTCATGAAGTCCA	0.458											OREG0021805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	33					0	0	0	0	T	50232622	T	T	50232622	3	4	303	1	0	0	0	0	1	0	0	0	1359	826	29	2	471	2	BCDIN3D	12	50232622	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	36987	50232622	83619273	431	55958											
DIP2B	57609	broad.mit.edu	37	chr12	51077027	51077027	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatagaggtacctcttaccaGaaaggtaacattgctaaatt	15	12	7	7	0	1	2	0	0	1	2	1	2	1	2	2	2	4	3	2	2	8	8			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:51077027G>A	uc001rwv.2	+	10	1469	c.1313G>A	c.(1312-1314)AGA>AAA	p.R438K	DIP2B_uc009zlt.2_5'Flank	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	438						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						CCTCTTACCAGAAAGGTAACA	0.433													21	38					0	0	0	0	A	51077027	A	A	51077027	3	1	303	1	0	0	0	0	1	0	0	0	4550	942	33	2	1351	2	DIP2B	12	51077027	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	844405	51077027	82774868	432	55959											
LETMD1	25875	broad.mit.edu	37	chr12	51445895	51445895	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gattgcagatgttatgggctGatgccaaaaaggctagaaga	14	9	13	5	0	0	4	0	1	0	3	0	5	0	4	1	2	2	4	1	2	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:51445895G>A	uc001rxm.2	+	3	351	c.295G>A	c.(295-297)GAT>AAT	p.D99N	LETMD1_uc010smz.1_Intron|LETMD1_uc010sna.1_Intron|LETMD1_uc001rxl.2_Missense_Mutation_p.D43N|LETMD1_uc009zlv.2_Intron|LETMD1_uc001rxs.2_Intron|LETMD1_uc009zlw.2_Missense_Mutation_p.D99N|LETMD1_uc001rxn.2_Intron|LETMD1_uc001rxo.2_Intron|LETMD1_uc001rxp.2_Intron|LETMD1_uc001rxq.2_Missense_Mutation_p.D99N|LETMD1_uc001rxr.2_Intron|LETMD1_uc001rxt.2_Intron	NM_015416	NP_056231	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1 isoform 1	99	Cytoplasmic (Potential).|LETM1.|Required and sufficient for mitochondrial import.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)	2						GTTATGGGCTGATGCCAAAAA	0.398													10	31					0	0	0	0	A	51445895	A	A	51445895	3	1	303	1	0	0	0	0	1	0	0	0	8776	1290	45	2	305	2	LETMD1	12	51445895	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	368868	51445895	82406000	433	55960											
ACVRL1	94	broad.mit.edu	37	chr12	52314580	52314580	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tcagatgatgcgggagtgctGgtacccaaacccctctgccc	8	8	11	14	1	2	2	1	1	1	1	2	3	2	3	4	2	5	2	4	2	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:52314580G>A	uc001rzj.2	+	10	1698	c.1415G>A	c.(1414-1416)TGG>TAG	p.W472*	ACVRL1_uc001rzk.2_Nonsense_Mutation_p.W472*|ACVRL1_uc010snm.1_Nonsense_Mutation_p.W298*	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	472	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CGGGAGTGCTGGTACCCAAAC	0.438									Hereditary_Hemorrhagic_Telangiectasia				11	43					0	0	0	0	A	52314580	A	A	52314580	4	1	303	1	0	0	0	0	0	1	0	0	225	1357	47	4	1449	4	ACVRL1	12	52314580	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	868685	52314580	81537315	434	55961											
KRT82	3888	broad.mit.edu	37	chr12	52799720	52799720	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcatccctctttaccctCtgcacagtcgggtctatctc	5	15	5	16	1	5	0	1	0	5	0	9	0	6	0	2	1	2	1	2	1	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:52799720C>T	uc001sai.1	-	1	457	c.342G>A	c.(340-342)CAG>CAA	p.Q114Q		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	114	Head.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		TCTTTACCCTCTGCACAGTCG	0.577													64	139					0	0	0	0	T	52799720	T	T	52799720	2	4	303	1	0	0	0	0	0	0	0	1	8535	912	32	2		2	KRT82	12	52799720	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	485140	52799720	81052175	435	55962											
ESPL1	9700	broad.mit.edu	37	chr12	53675335	53675335	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcctgaagcatctcgatcaGactactgacacatacctgct	12	9	7	13	1	2	3	1	2	1	1	3	4	2	3	2	0	5	2	2	0	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:53675335G>T	uc001sck.2	+	13	2635	c.2544G>T	c.(2542-2544)CAG>CAT	p.Q848H	ESPL1_uc001scj.2_Missense_Mutation_p.Q523H|ESPL1_uc010soe.1_Missense_Mutation_p.Q59H	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	848					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						ATCTCGATCAGACTACTGACA	0.483													22	66					3.62473e-10	3.72224e-10	1	0	T	53675335	T	T	53675335	3	4	303	1	0	0	0	0	1	0	0	0	5277	933	33	2	2590	2	ESPL1	12	53675335	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	875615	53675335	80176560	436	55963											
HOXC10	3226	broad.mit.edu	37	chr12	54379124	54379124	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggaggagagcgctatagccgGagcgcaggcatgtatatgca	11	6	16	8	3	0	1	0	0	0	1	0	4	0	3	1	4	4	5	1	4	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:54379124G>A	uc001sen.2	+	1	179	c.81G>A	c.(79-81)CGG>CGA	p.R27R		NM_017409	NP_059105	Q9NYD6	HXC10_HUMAN	homeobox C10	27					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1						GCTATAGCCGGAGCGCAGGCA	0.612													30	55					0	0	0	0	A	54379124	A	A	54379124	2	1	303	1	0	0	0	0	0	0	0	1	7348	1161	41	2		2	HOXC10	12	54379124	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	703789	54379124	79472771	437	55964											
HOXC10	3226	broad.mit.edu	37	chr12	54383229	54383229	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctccaattttaatttcacctGagagcgcggcctctcctcct	7	13	6	15	2	2	1	1	1	1	1	5	2	4	1	5	1	1	0	5	1	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:54383229G>C	uc001sen.2	+	2	1126	c.1028G>C	c.(1027-1029)TGA>TCA	p.*343S	uc001seo.2_5'Flank|MIR196A2_hsa-mir-196a-2|MI0000279_5'Flank	NM_017409	NP_059105	Q9NYD6	HXC10_HUMAN	homeobox C10	343					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1						AATTTCACCTGAGAGCGCGGc	0.303											OREG0021882	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	12					0	0	0	0	C	54383229	C	C	54383229	4	2	303	1	0	0	0	0	0	0	0	0	7348	1285	45	2	1034	2	HOXC10	12	54383229	Nonstop_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4105	54383229	79468666	438	55965											
GDF11	10220	broad.mit.edu	37	chr12	56142406	56142406	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gacagatggcagccctctctGctgccattttcacttcagcc	7	11	8	15	0	3	1	2	0	1	1	4	2	3	1	3	1	4	2	3	1	0	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:56142406G>A	uc001shq.2	+	2	519	c.482G>A	c.(481-483)TGC>TAC	p.C161Y	GDF11_uc010spv.1_Missense_Mutation_p.C161Y	NM_005811	NP_005802	O95390	GDF11_HUMAN	growth differentiation factor 11 precursor	161					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			kidney(1)	1						AGCCCTCTCTGCTGCCATTTT	0.562													53	164					0	0	0	0	A	56142406	A	A	56142406	3	1	303	1	0	0	0	0	1	0	0	0	6349	1319	46	4	488	4	GDF11	12	56142406	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1759177	56142406	77709489	439	55966											
DNAJC14	85406	broad.mit.edu	37	chr12	56221092	56221092	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacatctgatgctgtggcctCaacccccagtacatggaaag	12	8	9	12	0	2	1	1	1	1	0	2	2	2	2	3	2	4	2	3	2	4	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:56221092C>T	uc001shx.1	-	2	1555	c.1351G>A	c.(1351-1353)GAG>AAG	p.E451K	DNAJC14_uc001shu.1_Missense_Mutation_p.E451K|DNAJC14_uc009zob.1_Missense_Mutation_p.E451K|DNAJC14_uc001shy.1_Missense_Mutation_p.E451K	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	451	J.				protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						GCTGTGGCCTCAACCCCCAGT	0.512													53	114					0	0	0	0	T	56221092	T	T	56221092	3	4	303	1	0	0	0	0	1	0	0	0	4655	835	29	2	781	2	DNAJC14	12	56221092	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	78686	56221092	77630803	440	55967											
BAZ2A	11176	broad.mit.edu	37	chr12	56998928	56998928	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaccagcaggtcttgcacctCacccaagctgtcaccttgac	9	8	8	16	0	3	1	2	1	1	0	3	2	3	1	4	1	3	3	4	1	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:56998928C>T	uc001slq.1	-	14	2877	c.2683G>A	c.(2683-2685)GAG>AAG	p.E895K	BAZ2A_uc001slp.1_Missense_Mutation_p.E893K|BAZ2A_uc001slo.1_5'Flank|BAZ2A_uc009zov.1_5'Flank|BAZ2A_uc009zow.1_Missense_Mutation_p.E863K	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	895	DDT.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						TCTTGCACCTCACCCAAGCTG	0.572													15	42					0	0	0	0	T	56998928	T	T	56998928	3	4	303	1	0	0	0	0	1	0	0	0	1333	835	29	2	3098	2	BAZ2A	12	56998928	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	777836	56998928	76852967	441	55968											
CTDSP2	10106	broad.mit.edu	37	chr12	58220809	58220809	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctatgcacaagggtttcatcGaggtcaatgaccacacagat	13	9	9	10	1	2	2	2	1	0	1	3	3	2	2	1	2	1	2	1	2	3	2	rs78691025		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:58220809G>A	uc001sqm.2	-	4	853	c.324C>T	c.(322-324)CTC>CTT	p.L108L	CTDSP2_uc010ssg.1_5'Flank|CTDSP2_uc009zqf.2_5'UTR|CTDSP2_uc009zqg.2_Intron|uc001sqn.2_5'Flank|MIR26A2_hsa-mir-26a-2|MI0000750_5'Flank	NM_005730	NP_005721	O14595	CTDS2_HUMAN	nuclear LIM interactor-interacting factor 2	108	FCP1 homology.				protein dephosphorylation	nucleus|soluble fraction	CTD phosphatase activity|metal ion binding			central_nervous_system(1)	1	all_neural(12;0.00559)|Glioma(12;0.0143)|Melanoma(17;0.122)					GGGTTTCATCGAGGTCAATGA	0.488													15	48					0	0	0	0	A	58220809	A	A	58220809	2	1	303	1	0	0	0	0	0	0	0	1	4021	1045	37	1		1	CTDSP2	12	58220809	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1221881	58220809	75631086	442	55969											
USP15	9958	broad.mit.edu	37	chr12	62783731	62783731	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtaccacgaaacaatactGaagacaaactttataatctc	17	10	4	10	1	1	2	0	1	1	1	2	3	1	2	1	0	4	1	1	0	8	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:62783731G>C	uc001src.1	+	14	1816	c.1807G>C	c.(1807-1809)GAA>CAA	p.E603Q	USP15_uc001srb.1_Missense_Mutation_p.E574Q	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	603					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		AAACAATACTGAAGACAAACT	0.353													5	19					0	0	0	0	C	62783731	C	C	62783731	3	2	303	1	0	0	0	0	1	0	0	0	17114	1291	45	2	1770	2	USP15	12	62783731	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4562922	62783731	71068164	443	55970											
E2F7	144455	broad.mit.edu	37	chr12	77444488	77444488	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgcttggcctttgcttttCaaattcgtccacagcactgt	6	16	7	12	1	2	0	1	0	1	0	4	0	3	0	2	1	3	3	2	1	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:77444488C>G	uc001sym.3	-	4	642	c.406G>C	c.(406-408)GAA>CAA	p.E136Q	E2F7_uc001syn.2_Missense_Mutation_p.E136Q	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	136					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						CTTTGCTTTTCAAATTCGTCC	0.453													15	25					0	0	0	0	G	77444488	G	G	77444488	3	3	303	1	0	0	0	0	1	0	0	0	4894	835	29	2	2369	2	E2F7	12	77444488	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	14660757	77444488	56407407	444	55971											
MYF6	4618	broad.mit.edu	37	chr12	81101775	81101775	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agagaaaatctgcccccactGaccggcgaaaagccgccacc	13	3	9	16	3	1	2	0	1	1	1	1	4	1	2	6	1	2	0	6	1	4	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:81101775G>A	uc001szf.1	+	1	330	c.277G>A	c.(277-279)GAC>AAC	p.D93N		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	93	Basic motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						TGCCCCCACTGACCGGCGAAA	0.622													10	27					0	0	0	0	A	81101775	A	A	81101775	3	1	303	1	0	0	0	0	1	0	0	0	10081	1290	45	2	279	2	MYF6	12	81101775	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3657287	81101775	52750120	445	55972											
LRRIQ1	84125	broad.mit.edu	37	chr12	85517849	85517849	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcatcatttatttgttcagaGatgtatttaccttggatact	10	19	6	6	0	3	1	3	0	0	1	3	3	3	2	1	1	2	2	1	1	4	9			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:85517849G>C	uc001tac.2	+	17	3670	c.3559G>C	c.(3559-3561)GAT>CAT	p.D1187H	LRRIQ1_uc001tab.1_Missense_Mutation_p.D1187H	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1187										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TTTGTTCAGAGATGTATTTAC	0.323													11	18					0	0	0	0	C	85517849	C	C	85517849	3	2	303	1	0	0	0	0	1	0	0	0	9079	956	33	2	3621	2	LRRIQ1	12	85517849	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4416074	85517849	48334046	446	55973											
GALNT4	8693	broad.mit.edu	37	chr12	89919631	89919632	+	5'Flank	DEL	CC	-	-																															ggacaggctccagggagggaCcccccccacctccaacccgt																								rs67346689		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:89919631_89919632delCC	uc001tbd.2	-						POC1B_uc001tba.2_5'Flank|POC1B_uc001tbb.2_5'Flank|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Intron|GALNT4_uc010suo.1_Intron	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4						carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						CAGGGAGGGACCCCCCCCACCT	0.668													---	---	---								-	89919632	-	-	89919631	6	5	303	0	1	1	0	1	0	0	0	0	6250	522	18	0		0	GALNT4	12	89919631	5'Flank	DEL	CC	TCGA-HL-7533-01A-11D-2229-08	4401782	89919631	43932264	447	55974											
ATP2B1	490	broad.mit.edu	37	chr12	89997547	89997547	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgcatgacccaaaatattCttcatcattgtacgtgagat	14	13	6	8	1	3	2	2	2	1	1	3	3	3	2	1	0	2	2	1	0	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:89997547C>G	uc001tbh.2	-	16	2971	c.2790G>C	c.(2788-2790)AAG>AAC	p.K930N	ATP2B1_uc001tbg.2_Missense_Mutation_p.K930N|ATP2B1_uc001tbf.2_Missense_Mutation_p.K600N	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	930	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						CCAAAATATTCTTCATCATTG	0.403													24	54					0	0	0	0	G	89997547	G	G	89997547	3	3	303	1	0	0	0	0	1	0	0	0	1141	912	32	2	1050	2	ATP2B1	12	89997547	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	77916	89997547	43854348	448	55975											
VEZT	55591	broad.mit.edu	37	chr12	95676361	95676361	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	caacagaagtcaagagaactGaataatgttcacacagcagt	18	7	8	8	0	2	3	2	1	0	2	2	4	2	3	0	0	3	2	0	0	6	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:95676361G>A	uc001tdz.2	+	8	1374	c.1269G>A	c.(1267-1269)CTG>CTA	p.L423L	VEZT_uc009ztb.1_RNA|VEZT_uc009ztc.1_Intron|VEZT_uc001tdy.2_RNA	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	423						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						CAAGAGAACTGAATAATGTTC	0.408													16	41					0	0	0	0	A	95676361	A	A	95676361	2	1	303	1	0	0	0	0	0	0	0	1	17224	1277	45	2		2	VEZT	12	95676361	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5678814	95676361	38175534	449	55976											
ELK3	2004	broad.mit.edu	37	chr12	96640826	96640826	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agatcagccgggagagccttCtgctgcaggacagcgactgc	9	6	14	12	2	2	2	1	0	1	2	2	5	2	3	2	2	6	2	2	2	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:96640826C>G	uc001teo.1	+	3	595	c.316C>G	c.(316-318)CTG>GTG	p.L106V		NM_005230	NP_005221	P41970	ELK3_HUMAN	ELK3 protein	106					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	all_cancers(2;0.00173)					GGAGAGCCTTCTGCTGCAGGA	0.597													6	13					0	0	0	0	G	96640826	G	G	96640826	3	3	303	1	0	0	0	0	1	0	0	0	5084	912	32	2	322	2	ELK3	12	96640826	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	964465	96640826	37211069	450	55977											
APAF1	317	broad.mit.edu	37	chr12	99053108	99053108	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctccgcattctgatgcttCgcaaacacccaaggtaccga	10	9	8	14	3	2	1	0	1	2	0	4	2	2	1	3	1	3	4	3	1	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:99053108C>T	uc001tfz.2	+	5	1274	c.697C>T	c.(697-699)CGC>TGC	p.R233C	APAF1_uc001tfy.2_Missense_Mutation_p.R222C|APAF1_uc001tga.2_Missense_Mutation_p.R222C|APAF1_uc001tgb.2_Missense_Mutation_p.R233C|APAF1_uc001tgc.2_Missense_Mutation_p.R233C	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	233	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	TCTGATGCTTCGCAAACACCC	0.453													9	23					0	0	0	0	T	99053108	T	T	99053108	3	4	303	1	0	0	0	0	1	0	0	0	755	884	31	1	711	1	APAF1	12	99053108	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2412282	99053108	34798787	451	55978											
NUP37	79023	broad.mit.edu	37	chr12	102505992	102505992	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttttatactgaatgccttCaacgtctgcttcttcttcct	6	19	5	11	1	4	1	1	1	3	0	5	1	5	1	2	0	4	2	2	0	4	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:102505992C>T	uc001tjc.2	-	2	240	c.175G>A	c.(175-177)GAA>AAA	p.E59K	NUP37_uc009zub.1_Missense_Mutation_p.E59K	NM_024057	NP_076962	Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	59					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			ovary(1)	1						TGAATGCCTTCAACGTCTGCT	0.353													13	42					0	0	0	0	T	102505992	T	T	102505992	3	4	303	1	0	0	0	0	1	0	0	0	10818	835	29	2	837	2	NUP37	12	102505992	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3452884	102505992	31345903	452	55979											
SLC41A2	84102	broad.mit.edu	37	chr12	105322118	105322118	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	ataatccatcttgccaaatgCcgtttgcttttttgtgcctg	7	17	7	10	1	1	0	0	0	1	0	2	0	2	0	4	0	4	2	4	0	2	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:105322118C>T	uc001tla.2	-	1	355	c.188G>A	c.(187-189)GGC>GAC	p.G63D		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	63	Extracellular.					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TTGCCAAATGCCGTTTGCTTT	0.373													3	10					0	0	0	0	T	105322118	T	T	105322118	3	4	303	1	0	0	0	0	1	0	0	0	14694	739	26	4	1573	4	SLC41A2	12	105322118	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2816126	105322118	28529777	453	55980											
TCP11L2	255394	broad.mit.edu	37	chr12	106708139	106708139	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttttgtttttctttcagcaaCaagccctccaagggttgtaa	9	16	7	9	0	2	0	1	0	1	0	3	0	3	0	2	1	3	4	2	1	4	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:106708139C>G	uc001tln.2	+	3	335	c.161C>G	c.(160-162)ACA>AGA	p.T54R	TCP11L2_uc001tll.2_Missense_Mutation_p.T54R|TCP11L2_uc001tlm.2_Missense_Mutation_p.T54R	NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	54	Ser-rich.									ovary(3)	3						CTTTCAGCAACAAGCCCTCCA	0.378													11	57					0	0	0	0	G	106708139	G	G	106708139	3	3	303	1	0	0	0	0	1	0	0	0	15781	478	17	4	167	4	TCP11L2	12	106708139	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1386021	106708139	27143756	454	55981											
UNG	7374	broad.mit.edu	37	chr12	109539779	109539779	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acgggctctgctttagtgttCaaaggcctgttccgcctccg	5	12	11	13	3	2	0	1	0	1	0	4	0	4	0	4	2	1	4	4	2	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:109539779C>G	uc001tnz.1	+	4	578	c.508C>G	c.(508-510)CAA>GAA	p.Q170E	UNG_uc001toa.1_Missense_Mutation_p.Q161E	NM_080911	NP_550433	P13051	UNG_HUMAN	uracil-DNA glycosylase isoform UNG2	170					base-excision repair|interspecies interaction between organisms	mitochondrion|nucleus	protein binding|uracil DNA N-glycosylase activity			lung(1)|central_nervous_system(1)	2						CTTTAGTGTTCAAAGGCCTGT	0.493								BER_DNA_glycosylases	Immune_Deficiency_with_Hyper-IgM				9	42					0	0	0	0	G	109539779	G	G	109539779	3	3	303	1	0	0	0	0	1	0	0	0	17067	827	29	2	627	2	UNG	12	109539779	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2831640	109539779	24312116	455	55982											
ACACB	32	broad.mit.edu	37	chr12	109678960	109678960	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cgtgtgctacaggctgaggtCaagatcaacatccgccagac	11	7	11	12	2	2	3	2	1	0	2	3	3	3	3	2	2	3	2	2	2	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:109678960C>G	uc001tob.2	+	36	5015	c.4896C>G	c.(4894-4896)GTC>GTG	p.V1632V	ACACB_uc001toc.2_Silent_p.V1632V|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.V298V	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1632					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	AGGCTGAGGTCAAGATCAACA	0.572													64	202					0	0	0	0	G	109678960	G	G	109678960	2	3	303	1	0	0	0	0	0	0	0	1	107	813	29	2		2	ACACB	12	109678960	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	139181	109678960	24172935	456	55983											
ACACB	32	broad.mit.edu	37	chr12	109680251	109680251	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctggtccagatcatgtttCactccttcggcaacaagcaa	10	12	7	12	1	3	1	2	0	1	1	6	1	5	1	2	2	2	3	2	2	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:109680251C>T	uc001tob.2	+	37	5151	c.5032C>T	c.(5032-5034)CAC>TAC	p.H1678Y	ACACB_uc001toc.2_Missense_Mutation_p.H1678Y|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.H344Y	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1678					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GATCATGTTTCACTCCTTCGG	0.517													23	67					0	0	0	0	T	109680251	T	T	109680251	3	4	303	1	0	0	0	0	1	0	0	0	107	826	29	2	5174	2	ACACB	12	109680251	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1291	109680251	24171644	457	55984											
ACACB	32	broad.mit.edu	37	chr12	109685464	109685464	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tacaccagaatcagctccctGaactccgtccactgtaaaca	13	8	5	15	1	1	2	1	1	0	1	4	2	4	2	4	0	4	2	4	0	5	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:109685464G>A	uc001tob.2	+	40	5744	c.5625G>A	c.(5623-5625)CTG>CTA	p.L1875L	ACACB_uc001toc.2_Silent_p.L1875L|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.L541L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1875	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TCAGCTCCCTGAACTCCGTCC	0.433													27	85					0	0	0	0	A	109685464	A	A	109685464	2	1	303	1	0	0	0	0	0	0	0	1	107	1277	45	2		2	ACACB	12	109685464	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5213	109685464	24166431	458	55985											
ACACB	32	broad.mit.edu	37	chr12	109685501	109685501	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacacatcgaggaaggaggaGagtccaggtaaataacttat	17	7	11	6	1	0	1	0	0	0	1	2	5	1	3	1	4	2	1	1	4	6	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:109685501G>A	uc001tob.2	+	40	5781	c.5662G>A	c.(5662-5664)GAG>AAG	p.E1888K	ACACB_uc001toc.2_Missense_Mutation_p.E1888K|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.E554K	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1888	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGAAGGAGGAGAGTCCAGGTA	0.443													15	57					0	0	0	0	A	109685501	A	A	109685501	3	1	303	1	0	0	0	0	1	0	0	0	107	943	33	2	5816	2	ACACB	12	109685501	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	37	109685501	24166394	459	55986											
IFT81	28981	broad.mit.edu	37	chr12	110574587	110574587	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgtattttaaagctatttCatgcagtgcaaagattgcaa	14	15	7	5	0	1	1	1	0	0	1	1	1	1	1	0	0	4	5	0	0	6	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:110574587C>T	uc001tqi.2	+	8	833	c.703C>T	c.(703-705)CAT>TAT	p.H235Y	IFT81_uc001tqh.2_Missense_Mutation_p.H235Y|IFT81_uc001tqj.2_RNA|IFT81_uc001tqg.2_Missense_Mutation_p.H235Y	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	235	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						AAAGCTATTTCATGCAGTGCA	0.358													4	8					0	0	0	0	T	110574587	T	T	110574587	3	4	303	1	0	0	0	0	1	0	0	0	7604	826	29	2	729	2	IFT81	12	110574587	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	889086	110574587	23277308	460	55987											
PPTC7	160760	broad.mit.edu	37	chr12	110983764	110983764	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gttgaagtaatgctgctgctCatctgatcggtgcacgactt	8	13	11	9	2	2	2	1	2	1	0	3	3	2	2	0	1	4	6	0	1	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:110983764C>T	uc001trh.1	-	3	751	c.523G>A	c.(523-525)GAG>AAG	p.E175K		NM_139283	NP_644812	Q8NI37	PPTC7_HUMAN	T-cell activation protein phosphatase 2C	175	PP2C-like.						metal ion binding|phosphoprotein phosphatase activity				0						TGCTGCTGCTCATCTGATCGG	0.562													37	68					0	0	0	0	T	110983764	T	T	110983764	3	4	303	1	0	0	0	0	1	0	0	0	12473	835	29	2	407	2	PPTC7	12	110983764	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	409177	110983764	22868131	461	55988											
ATXN2	6311	broad.mit.edu	37	chr12	111956212	111956212	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ttctctatttctttgtccagGaggaatatatttattttccc	8	20	5	8	0	2	0	0	0	2	0	5	2	4	2	2	2	0	0	2	2	5	10			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:111956212G>A	uc001tsj.2	-	9	1648	c.1486C>T	c.(1486-1488)CCT>TCT	p.P496S	ATXN2_uc001tsh.2_Missense_Mutation_p.P231S|ATXN2_uc001tsi.2_Missense_Mutation_p.P207S|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_Missense_Mutation_p.P231S	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	496					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						CTTTGTCCAGGAGGAATATAT	0.418													14	68					0	0	0	0	A	111956212	A	A	111956212	3	1	303	1	0	0	0	0	1	0	0	0	1213	1174	41	2	2523	2	ATXN2	12	111956212	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	972448	111956212	21895683	462	55989											
TRAFD1	10906	broad.mit.edu	37	chr12	112580000	112580000	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tggccctaagtctgcaaaatGaaggccaagcctccagtgtg	11	8	11	11	0	1	1	0	1	1	0	2	1	2	1	4	2	2	1	4	2	5	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:112580000G>T	uc001ttp.2	+	6	837	c.751G>T	c.(751-753)GAA>TAA	p.E251*	TRAFD1_uc001tto.2_Nonsense_Mutation_p.E251*|TRAFD1_uc010syj.1_RNA	NM_006700	NP_006691	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	251					negative regulation of innate immune response	intracellular	protein binding|zinc ion binding				0						TCTGCAAAATGAAGGCCAAGC	0.552													24	44					9.39395e-14	9.74927e-14	1	0	T	112580000	T	T	112580000	4	4	303	1	0	0	0	0	0	1	0	0	16514	1291	45	2	769	2	TRAFD1	12	112580000	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	623788	112580000	21271895	463	55990											
CCDC60	160777	broad.mit.edu	37	chr12	119773055	119773055	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tgtccggcccttttatgcctCggagaacctaaggcaggtaa	9	10	11	11	2	0	1	0	0	0	1	2	2	1	1	4	4	2	2	4	4	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:119773055C>G	uc001txe.2	+	1	539	c.74C>G	c.(73-75)TCG>TGG	p.S25W		NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	25										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		TTTTATGCCTCGGAGAACCTA	0.413													11	45					0	0	0	0	G	119773055	G	G	119773055	3	3	303	1	0	0	0	0	1	0	0	0	2844	893	31	3	76	3	CCDC60	12	119773055	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	7193055	119773055	14078840	464	55991											
RPLP0	6175	broad.mit.edu	37	chr12	120636497	120636497	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	catgttcagcagcgtggcttCgctggctcccactttgtctc	4	13	10	14	2	2	0	1	0	1	0	5	0	3	0	1	2	2	5	1	2	0	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:120636497C>T	uc001txp.2	-	6	748	c.511G>A	c.(511-513)GAA>AAA	p.E171K	RPLP0_uc001txq.2_Missense_Mutation_p.E171K|RPLP0_uc001txr.2_Intron|uc001txs.1_5'Flank	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	171					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGCGTGGCTTCGCTGGCTCCC	0.522													13	41					0	0	0	0	T	120636497	T	T	120636497	3	4	303	1	0	0	0	0	1	0	0	0	13669	893	31	1	454	1	RPLP0	12	120636497	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	863442	120636497	13215398	465	55992											
KDM2B	84678	broad.mit.edu	37	chr12	121868213	121868213	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gcagtacctcaggtcaatatGacagatgtttccacagcgtt	11	11	9	10	1	2	2	2	1	0	1	3	2	3	2	2	1	2	4	2	1	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:121868213G>C	uc001uat.2	-	23	3993	c.3889C>G	c.(3889-3891)CAT>GAT	p.H1297D	KDM2B_uc001uaq.2_Missense_Mutation_p.H737D|KDM2B_uc010szy.1_Missense_Mutation_p.H737D|KDM2B_uc001uar.2_Missense_Mutation_p.H888D|KDM2B_uc001uas.2_Missense_Mutation_p.H1228D|KDM2B_uc001uau.2_Silent_p.V556V|RNF34_uc001uam.1_Missense_Mutation_p.M480I|KDM2B_uc001uao.2_Missense_Mutation_p.H545D|KDM2B_uc010szx.1_Missense_Mutation_p.H545D|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	1297	LRR 6.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						AGGTCAATATGACAGATGTTT	0.468													34	77					0	0	0	0	C	121868213	C	C	121868213	3	2	303	1	0	0	0	0	1	0	0	0	8164	1290	45	2	177	2	KDM2B	12	121868213	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1231716	121868213	11983682	466	55993											
TMEM132B	114795	broad.mit.edu	37	chr12	125834094	125834094	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	catctccaatgcagaggagtCctttttccttaaagaagcca	12	11	7	11	0	1	2	0	0	1	2	4	3	3	3	4	1	2	1	4	1	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:125834094C>T	uc001uhe.1	+	2	157	c.149C>T	c.(148-150)TCC>TTC	p.S50F		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	50	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GCAGAGGAGTCCTTTTTCCTT	0.537													43	77					0	0	0	0	T	125834094	T	T	125834094	3	4	303	1	0	0	0	0	1	0	0	0	16112	855	30	2	155	2	TMEM132B	12	125834094	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3965881	125834094	8017801	467	55994											
FZD10	11211	broad.mit.edu	37	chr12	130648351	130648351	+	Silent	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgccggcgccgagagcatCgcctgcgaccgggacagcgg	6	4	16	15	8	0	1	0	0	0	1	2	4	0	2	4	3	3	1	4	3	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:130648351C>A	uc001uii.2	+	1	1320	c.864C>A	c.(862-864)ATC>ATA	p.I288I	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	288	Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CCGAGAGCATCGCCTGCGACC	0.642													33	82					1.69901e-12	1.75498e-12	1	0	A	130648351	A	A	130648351	2	1	303	1	0	0	0	0	0	0	0	1	6163	874	31	3		3	FZD10	12	130648351	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4814257	130648351	3203544	468	55995											
ULK1	8408	broad.mit.edu	37	chr12	132403152	132403152	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gacacggctgcagctttgccGaccccattactgcgaacctg	8	8	10	15	3	0	0	0	0	0	0	0	3	0	0	4	1	6	3	4	1	2	2	rs143018342		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr12:132403152G>A	uc001uje.2	+	23	2705	c.2437G>A	c.(2437-2439)GAC>AAC	p.D813N		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	813					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CAGCTTTGCCGACCCCATTAC	0.672													6	16					0	0	0	0	A	132403152	A	A	132403152	3	1	303	1	0	0	0	0	1	0	0	0	17043	1058	37	1	2527	1	ULK1	12	132403152	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1754801	132403152	1448743	469	55996											
RNF17	56163	broad.mit.edu	37	chr13	25376518	25376518	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaattttactttcttgcacaGaatgaaggctgggaagagga	13	11	12	5	0	1	3	0	1	1	2	1	6	1	5	0	3	2	2	0	3	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:25376518G>C	uc001upr.2	+	14	1800	c.1759_splice	c.e14-1	p.N587_splice	RNF17_uc010tdd.1_Splice_Site_p.N446_splice|RNF17_uc010aab.2_Splice_Site|RNF17_uc010tde.1_Splice_Site_p.N587_splice|RNF17_uc001ups.2_Splice_Site_p.N526_splice	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17						multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTCTTGCACAGAATGAAGGCT	0.353													13	17					0	0	0	0	C	25376518	C	C	25376518	5	2	303	1	0	0	0	0	0	0	1	0	13526	956	33	2	1812	2	RNF17	13	25376518	Splice_Site	SNP	G	TCGA-HL-7533-01A-11D-2229-08		25376518	89793360	470	55997											
RNF17	56163	broad.mit.edu	37	chr13	25376660	25376660	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccgaataaaataagcagtGatatgcctgtgtctcttaga	14	11	8	8	1	1	2	0	1	1	1	2	3	1	2	2	0	2	1	2	0	6	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:25376660G>C	uc001upr.2	+	14	1941	c.1900G>C	c.(1900-1902)GAT>CAT	p.D634H	RNF17_uc010tdd.1_Missense_Mutation_p.D493H|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.D634H|RNF17_uc001ups.2_Missense_Mutation_p.D573H	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	634					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AATAAGCAGTGATATGCCTGT	0.318													33	53					0	0	0	0	C	25376660	C	C	25376660	3	2	303	1	0	0	0	0	1	0	0	0	13526	1290	45	2	1954	2	RNF17	13	25376660	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	142	25376660	89793218	471	55998											
ATP8A2	51761	broad.mit.edu	37	chr13	26411340	26411340	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccttcactctgggaatctttGagaggtcttgcactcaggag	8	12	11	10	0	5	1	2	1	3	1	5	4	5	3	1	3	1	1	1	3	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:26411340G>C	uc001uqk.2	+	29	2936	c.2794G>C	c.(2794-2796)GAG>CAG	p.E932Q	ATP8A2_uc010tdi.1_Missense_Mutation_p.E867Q|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.E482Q	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	892	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GGGAATCTTTGAGAGGTCTTG	0.498													27	58					0	0	0	0	C	26411340	C	C	26411340	3	2	303	1	0	0	0	0	1	0	0	0	1195	1291	45	2	2908	2	ATP8A2	13	26411340	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1034680	26411340	88758538	472	55999											
KATNAL1	84056	broad.mit.edu	37	chr13	30782829	30782829	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	aagtgcacggatttcttctgGacttaagccattgatacgcc	10	12	9	10	2	2	1	0	1	2	0	2	3	2	3	2	2	3	1	2	2	3	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:30782829G>C	uc001uss.2	-	11	1422	c.1321C>G	c.(1321-1323)CCA>GCA	p.P441A	KATNAL1_uc001ust.2_Missense_Mutation_p.P441A	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	441						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		ATTTCTTCTGGACTTAAGCCA	0.388													7	30					0	0	0	0	C	30782829	C	C	30782829	3	2	303	1	0	0	0	0	1	0	0	0	8024	1174	41	2	155	2	KATNAL1	13	30782829	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4371489	30782829	84387049	473	56000											
KL	9365	broad.mit.edu	37	chr13	33590999	33590999	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gcgacacggaggcgctgcgcGagctcggggtcactcactac	7	5	15	14	6	2	0	2	0	0	0	3	3	2	1	0	4	3	2	0	4	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:33590999G>A	uc001uus.2	+	1	429	c.421G>A	c.(421-423)GAG>AAG	p.E141K	KL_uc001uur.1_Intron	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	141	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GGCGCTGCGCGAGCTCGGGGT	0.706													6	26					0	0	0	0	A	33590999	A	A	33590999	3	1	303	1	0	0	0	0	1	0	0	0	8370	1059	37	1	423	1	KL	13	33590999	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2808170	33590999	81578879	474	56001											
TSC22D1	8848	broad.mit.edu	37	chr13	45147827	45147827	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggggaggcacagttaacaagGaactttgggatgcaataacc	14	7	13	7	0	0	0	0	0	0	0	0	3	0	3	1	5	4	3	1	5	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:45147827G>A	uc001uzn.3	-	1	2875	c.2384C>T	c.(2383-2385)TCC>TTC	p.S795F	TSC22D1_uc001uzo.1_Intron	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	795	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		AGTTAACAAGGAACTTTGGGA	0.473													24	70					0	0	0	0	A	45147827	A	A	45147827	3	1	303	1	0	0	0	0	1	0	0	0	16674	1174	41	2	978	2	TSC22D1	13	45147827	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	11556828	45147827	70022051	475	56002											
CYSLTR2	57105	broad.mit.edu	37	chr13	49281697	49281697	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cacaggaaggcactgaccacCatcatcatcaccttgatcat	13	8	6	14	0	4	2	4	2	0	0	4	3	4	3	3	2	0	1	3	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:49281697C>T	uc010acx.1	+	6	1427	c.744C>T	c.(742-744)ACC>ACT	p.T248T	CYSLTR2_uc010acy.1_Silent_p.T248T|CYSLTR2_uc010acz.1_Silent_p.T248T|CYSLTR2_uc010ada.1_Silent_p.T248T|CYSLTR2_uc010adb.1_Silent_p.T248T|CYSLTR2_uc010adc.1_Silent_p.T248T|CYSLTR2_uc010add.1_Silent_p.T248T|CYSLTR2_uc010acw.1_Silent_p.T248T|CYSLTR2_uc001vck.2_Silent_p.T248T	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	248	Helical; Name=6; (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	CACTGACCACCATCATCATCA	0.488													13	27					0	0	0	0	T	49281697	T	T	49281697	2	4	303	1	0	0	0	0	0	0	0	1	4219	581	21	4		4	CYSLTR2	13	49281697	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4133870	49281697	65888181	476	56003											
LMO7	4008	broad.mit.edu	37	chr13	76409469	76409469	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatttctccgaaagccttcaGagttctgtgagtatttggag	9	14	11	7	1	3	2	1	1	2	1	4	5	3	3	2	1	1	2	2	1	2	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:76409469G>C	uc001vjv.2	+	15	3388	c.2628G>C	c.(2626-2628)CAG>CAC	p.Q876H	LMO7_uc010thv.1_Missense_Mutation_p.Q827H|LMO7_uc001vjt.1_Missense_Mutation_p.Q775H|LMO7_uc010thw.1_Missense_Mutation_p.Q753H|LMO7_uc001vjw.1_Missense_Mutation_p.Q782H	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1161						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AAAGCCTTCAGAGTTCTGTGA	0.353													13	28					0	0	0	0	C	76409469	C	C	76409469	3	2	303	1	0	0	0	0	1	0	0	0	8897	933	33	2	3557	2	LMO7	13	76409469	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	27127772	76409469	38760409	477	56004											
MYCBP2	23077	broad.mit.edu	37	chr13	77785339	77785339	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tacaggatcaagacacacacCaaatccttgcagatcctctt	14	9	5	13	0	2	2	1	0	1	2	4	3	4	3	3	1	2	1	3	1	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:77785339C>G	uc001vkf.2	-	24	3356	c.3265G>C	c.(3265-3267)GGT>CGT	p.G1089R	MYCBP2_uc010aev.2_Missense_Mutation_p.G493R	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1089					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGACACACACCAAATCCTTGC	0.333													10	45					0	0	0	0	G	77785339	G	G	77785339	3	3	303	1	0	0	0	0	1	0	0	0	10071	594	21	4	10901	4	MYCBP2	13	77785339	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1375870	77785339	37384539	478	56005											
GPC5	2262	broad.mit.edu	37	chr13	92101020	92101020	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgttgtgtgttccaggacctGatcttcaggtttgcatatcc	6	16	10	9	0	2	1	1	1	1	0	4	2	4	2	3	2	1	4	3	2	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:92101020G>A	uc010tif.1	+	2	535	c.169G>A	c.(169-171)GAT>AAT	p.D57N		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	57						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TCCAGGACCTGATCTTCAGGT	0.413													12	57					0	0	0	0	A	92101020	A	A	92101020	3	1	303	1	0	0	0	0	1	0	0	0	6639	1290	45	2	175	2	GPC5	13	92101020	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	14315681	92101020	23068858	479	56006											
OXGR1	27199	broad.mit.edu	37	chr13	97639154	97639154	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcagagcagctaatggtctaGaaacgatgtaagcttcatgg	13	10	11	7	1	3	2	2	0	1	2	3	3	3	2	0	2	4	4	0	2	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:97639154G>C	uc001vmx.1	-	4	1104	c.860C>G	c.(859-861)TCT>TGT	p.S287C	OXGR1_uc010afr.1_Missense_Mutation_p.S287C	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	287	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			TAATGGTCTAGAAACGATGTA	0.438													17	59					0	0	0	0	C	97639154	C	C	97639154	3	2	303	1	0	0	0	0	1	0	0	0	11386	942	33	2	157	2	OXGR1	13	97639154	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5538134	97639154	17530724	480	56007											
TM9SF2	9375	broad.mit.edu	37	chr13	100193037	100193037	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctatgcctcatacccacattCagtggtttaggtaagagtac	11	12	8	10	0	2	1	2	0	0	1	2	1	2	1	2	2	3	3	2	2	5	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:100193037C>T	uc001voj.1	+	8	1031	c.898C>T	c.(898-900)CAG>TAG	p.Q300*	TM9SF2_uc010afz.1_Nonsense_Mutation_p.Q135*	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	300	Lumenal (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					TACCCACATTCAGTGGTTTAG	0.393													13	28					0	0	0	0	T	100193037	T	T	100193037	4	4	303	1	0	0	0	0	0	1	0	0	16044	827	29	2	928	2	TM9SF2	13	100193037	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2553883	100193037	14976841	481	56008											
TPP2	7174	broad.mit.edu	37	chr13	103287982	103287982	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagttcattcagtcagaaGagctctagaaaacactgcag	15	8	8	10	0	4	3	3	0	1	3	4	3	4	3	0	0	3	3	0	0	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:103287982G>A	uc001vpi.3	+	12	1542	c.1439G>A	c.(1438-1440)AGA>AAA	p.R480K		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	480					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCAGTCAGAAGAGCTCTAGAA	0.358													19	55					0	0	0	0	A	103287982	A	A	103287982	3	1	303	1	0	0	0	0	1	0	0	0	16479	942	33	2	1485	2	TPP2	13	103287982	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3094945	103287982	11881896	482	56009											
F7	2155	broad.mit.edu	37	chr13	113760173	113760173	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcatggtctcccaggccctCaggctcctctgccttctgct	4	12	8	17	0	5	0	2	0	3	0	7	0	6	0	4	3	2	2	4	3	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:113760173C>T	uc001vsv.2	+	1	69	c.18C>T	c.(16-18)CTC>CTT	p.L6L	F7_uc010agp.1_Silent_p.L21L|F7_uc001vsw.2_Silent_p.L6L|F7_uc010tjt.1_Silent_p.L21L	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	6					anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	CCCAGGCCCTCAGGCTCCTCT	0.592													4	9					0	0	0	0	T	113760173	T	T	113760173	2	4	303	1	0	0	0	0	0	0	0	1	5374	813	29	2		2	F7	13	113760173	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	10472191	113760173	1409705	483	56010											
F7	2155	broad.mit.edu	37	chr13	113772867	113772867	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	accagcccgtggtcctcactGaccatgtggtgcccctctgc	5	9	10	17	1	2	1	1	1	1	0	3	1	3	1	6	2	3	0	6	2	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:113772867G>C	uc001vsv.2	+	9	997	c.946G>C	c.(946-948)GAC>CAC	p.D316H	F7_uc001vsw.2_Missense_Mutation_p.D294H|F7_uc010tjt.1_Missense_Mutation_p.D247H	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	316	Peptidase S1.				anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	GGTCCTCACTGACCATGTGGT	0.677													12	52					0	0	0	0	C	113772867	C	C	113772867	3	2	303	1	0	0	0	0	1	0	0	0	5374	1290	45	2	980	2	F7	13	113772867	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	12694	113772867	1397011	484	56011											
CUL4A	8451	broad.mit.edu	37	chr13	113899295	113899295	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaagcattttataaaaaaGatttggcaaaaagactcctt	17	13	6	5	0	0	3	0	1	0	2	1	3	1	3	1	1	1	2	1	1	7	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr13:113899295G>C	uc010tjy.1	+	14	1377	c.1366G>C	c.(1366-1368)GAT>CAT	p.D456H	CUL4A_uc010tjx.1_Missense_Mutation_p.D356H|CUL4A_uc010agu.2_Missense_Mutation_p.D317H|CUL4A_uc010tjz.1_Missense_Mutation_p.D135H	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	456					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			TTATAAAAAAGATTTGGCAAA	0.373													12	28					0	0	0	0	C	113899295	C	C	113899295	3	2	303	1	0	0	0	0	1	0	0	0	4074	942	33	2	1416	2	CUL4A	13	113899295	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	126428	113899295	1270583	485	56012											
TEP1	7011	broad.mit.edu	37	chr14	20844028	20844028	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtcccagcagaggagactCtggataggccccaaggagag	12	4	14	11	1	1	3	0	0	1	3	2	6	2	4	3	4	1	1	3	4	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:20844028C>T	uc001vxe.2	-	43	6290	c.6250_splice	c.e43-1	p.S2084_splice	TEP1_uc010ahj.1_5'Flank|TEP1_uc010ahk.2_Splice_Site_p.S1427_splice|TEP1_uc010tlf.1_Splice_Site|TEP1_uc010tlg.1_Splice_Site_p.S1976_splice|TEP1_uc010tlh.1_Splice_Site_p.S422_splice	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1						telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGAGGAGACTCTGGATAGGCC	0.567													13	33					0	0	0	0	T	20844028	T	T	20844028	5	4	303	1	0	0	0	0	0	0	1	0	15825	927	32	2	1686	2	TEP1	14	20844028	Splice_Site	SNP	C	TCGA-HL-7533-01A-11D-2229-08		20844028	86505512	486	56013											
RNASE12	493901	broad.mit.edu	37	chr14	21058670	21058670	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccattgatttttcgaggcctCtcatggatgaagacatgctc	9	13	9	10	1	1	3	1	2	1	1	4	5	1	4	2	2	1	1	2	2	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:21058670C>T	uc001vxt.2	-	1	313	c.213G>A	c.(211-213)GAG>GAA	p.E71E	RNASE11_uc010ahv.2_5'Flank|RNASE11_uc010ahx.2_5'Flank|RNASE11_uc010ahw.2_5'Flank|RNASE11_uc001vxs.2_5'Flank|uc001vxu.1_RNA	NM_001024822	NP_001019993	Q5GAN4	RNS12_HUMAN	ribonuclease, RNase A family, 12 (non-active)	71						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(95;0.00238)		Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.013)		TTCGAGGCCTCTCATGGATGA	0.433													16	48					0	0	0	0	T	21058670	T	T	21058670	2	4	303	1	0	0	0	0	0	0	0	1	13467	912	32	2		2	RNASE12	14	21058670	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	214642	21058670	86290870	487	56014											
FLJ10357	55701	broad.mit.edu	37	chr14	21548926	21548926	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagctgcgattccgtgctttCagcgctgaggtccaggtgag	6	10	15	10	3	1	2	1	2	0	0	3	4	3	2	2	2	4	3	2	2	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:21548926C>G	uc001vzp.2	+	12	2510	c.2481C>G	c.(2479-2481)TTC>TTG	p.F827L	FLJ10357_uc001vzo.1_5'UTR|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_Missense_Mutation_p.F113L	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	827					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		TCCGTGCTTTCAGCGCTGAGG	0.637													16	41					0	0	0	0	G	21548926	G	G	21548926	3	3	303	1	0	0	0	0	1	0	0	0	5958	825	29	2	2527	2	FLJ10357	14	21548926	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	490256	21548926	85800614	488	56015											
RPGRIP1	57096	broad.mit.edu	37	chr14	21794056	21794056	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tcaccaagtgctgtggcctcCggagtcgatggctgggaact	7	9	14	11	2	1	0	1	0	0	0	3	3	2	2	3	4	2	2	3	4	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:21794056C>T	uc001wag.2	+	16	2434	c.2434C>T	c.(2434-2436)CGG>TGG	p.R812W	RPGRIP1_uc001wah.2_Missense_Mutation_p.R454W|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001wak.2_Missense_Mutation_p.R287W|RPGRIP1_uc010aim.2_Missense_Mutation_p.R195W|RPGRIP1_uc001wal.2_Missense_Mutation_p.R171W|RPGRIP1_uc001wam.2_Missense_Mutation_p.R129W	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	812	C2.		R -> H (does not affect the interaction with NPHP4).		response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CTGTGGCCTCCGGAGTCGATG	0.507													9	21					0	0	0	0	T	21794056	T	T	21794056	3	4	303	1	0	0	0	0	1	0	0	0	13614	643	23	1	2496	1	RPGRIP1	14	21794056	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	245130	21794056	85555484	489	56016											
SALL2	6297	broad.mit.edu	37	chr14	21992852	21992852	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aggcagtggcctcaaggcctCgggctgccccaagacactgt	8	6	13	14	1	1	1	1	0	0	1	2	1	1	1	4	4	1	2	4	4	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:21992852C>T	uc001wbe.2	-	2	1292	c.1010G>A	c.(1009-1011)CGA>CAA	p.R337Q	SALL2_uc010tly.1_Missense_Mutation_p.R335Q|SALL2_uc010tlz.1_Missense_Mutation_p.R200Q|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Missense_Mutation_p.R202Q|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	337							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CTCAAGGCCTCGGGCTGCCCC	0.607													6	18					0	0	0	0	T	21992852	T	T	21992852	3	4	303	1	0	0	0	0	1	0	0	0	13876	884	31	1	2017	1	SALL2	14	21992852	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	198796	21992852	85356688	490	56017											
LTB4R2	56413	broad.mit.edu	37	chr14	24780814	24780814	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgaaggctctggggaggcccGagggggcggccgctctaggg	5	4	21	11	4	2	0	0	0	2	0	2	3	2	1	2	8	0	2	2	8	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:24780814G>A	uc001woq.1	+	1	2654	c.1037G>A	c.(1036-1038)CGA>CAA	p.R346Q	CIDEB_uc001woo.2_5'Flank|CIDEB_uc001wop.2_5'Flank|LTB4R2_uc010alo.2_Missense_Mutation_p.R315Q|LTB4R2_uc001wor.2_Missense_Mutation_p.R315Q|LTB4R_uc001wos.2_5'UTR|LTB4R_uc010alp.2_5'Flank	NM_019839	NP_062813	Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	346	Cytoplasmic (Potential).				chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane					0				GBM - Glioblastoma multiforme(265;0.018)		GGGGAGGCCCGAGGGGGCGGC	0.687													22	54					0	0	0	0	A	24780814	A	A	24780814	3	1	303	1	0	0	0	0	1	0	0	0	9122	1058	37	1	946	1	LTB4R2	14	24780814	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2787962	24780814	82568726	491	56018											
HEATR5A	25938	broad.mit.edu	37	chr14	31771573	31771573	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaagcagtacggctcttttCtgcccgggccatgggagaag	8	8	13	12	2	2	1	0	0	2	1	2	2	2	1	3	3	3	3	3	3	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:31771573C>G	uc001wrf.3	-	27	4590	c.4513G>C	c.(4513-4515)GAA>CAA	p.E1505Q	HEATR5A_uc010ami.2_Intron	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1792							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		CGGCTCTTTTCTGCCCGGGCC	0.483													7	10					0	0	0	0	G	31771573	G	G	31771573	3	3	303	1	0	0	0	0	1	0	0	0	7070	922	32	2	764	2	HEATR5A	14	31771573	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6990759	31771573	75577967	492	56019											
AKAP6	9472	broad.mit.edu	37	chr14	33165305	33165305	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgtcagaggagcagcagcagCatctttacaaggttagagct	12	9	12	8	0	2	2	1	0	1	2	2	3	2	3	0	2	6	6	0	2	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:33165305C>T	uc001wrq.2	+	9	3159	c.2989C>T	c.(2989-2991)CAT>TAT	p.H997Y	AKAP6_uc010aml.2_Missense_Mutation_p.H994Y	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	997					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GCAGCAGCAGCATCTTTACAA	0.478													25	32					0	0	0	0	T	33165305	T	T	33165305	3	4	303	1	0	0	0	0	1	0	0	0	455	710	25	4	3019	4	AKAP6	14	33165305	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1393732	33165305	74184235	493	56020											
SSTR1	6751	broad.mit.edu	37	chr14	38678892	38678892	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaacatctacatcctaaatCtggccattgctgatgagctg	11	11	7	12	0	2	2	0	2	2	0	3	2	3	2	3	1	4	2	3	1	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:38678892C>T	uc001wul.1	+	3	915	c.298C>T	c.(298-300)CTG>TTG	p.L100L	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	100	Helical; Name=2; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	CATCCTAAATCTGGCCATTGC	0.582													42	102					0	0	0	0	T	38678892	T	T	38678892	2	4	303	1	0	0	0	0	0	0	0	1	15263	912	32	2		2	SSTR1	14	38678892	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5513587	38678892	68670648	494	56021											
PNN	5411	broad.mit.edu	37	chr14	39650039	39650039	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaactgaggtaagggaaagtGagaagcagcaggatagtcag	17	5	15	4	0	1	2	1	2	0	1	1	5	1	4	0	3	3	3	0	3	5	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:39650039G>A	uc001wuw.3	+	9	1223	c.1126G>A	c.(1126-1128)GAG>AAG	p.E376K		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	376	Potential.|Glu-rich.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		aagggaaagtgagaagcagca	0.174													9	19					0	0	0	0	A	39650039	A	A	39650039	3	1	303	1	0	0	0	0	1	0	0	0	12215	1291	45	2	1160	2	PNN	14	39650039	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	971147	39650039	67699501	495	56022											
CTAGE5	4253	broad.mit.edu	37	chr14	39796071	39796071	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttttttctttaattaggctCacgaggcccagggaatcctc	8	15	8	10	1	2	0	1	0	1	0	4	2	3	1	2	3	0	1	2	3	3	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:39796071C>G	uc001wvg.3	+	20	2012	c.1676C>G	c.(1675-1677)TCA>TGA	p.S559*	CTAGE5_uc010tqe.1_Nonsense_Mutation_p.S521*|CTAGE5_uc001wuz.3_Nonsense_Mutation_p.S547*|CTAGE5_uc001wuy.3_Nonsense_Mutation_p.S479*|CTAGE5_uc001wvb.3_Nonsense_Mutation_p.S487*|CTAGE5_uc001wvc.3_Nonsense_Mutation_p.S461*|CTAGE5_uc001wva.3_Nonsense_Mutation_p.S530*|CTAGE5_uc001wvh.3_Nonsense_Mutation_p.S516*|CTAGE5_uc001wvf.3_Nonsense_Mutation_p.S484*|CTAGE5_uc001wvi.3_Nonsense_Mutation_p.S564*|CTAGE5_uc010amz.2_Nonsense_Mutation_p.S175*|CTAGE5_uc001wvj.3_Nonsense_Mutation_p.S530*	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	559	Pro-rich.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		TAATTAGGCTCACGAGGCCCA	0.358													16	42					0	0	0	0	G	39796071	G	G	39796071	4	3	303	1	0	0	0	0	0	1	0	0	4011	838	29	2	1785	2	CTAGE5	14	39796071	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	146032	39796071	67553469	496	56023											
FAM179B	23116	broad.mit.edu	37	chr14	45475280	45475280	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gagatcgccatcttcccgacGaggtctaaatgggacaaagc	12	7	11	11	3	2	1	0	0	2	1	4	5	3	2	2	2	1	0	2	2	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:45475280G>A	uc001wvv.2	+	5	2923	c.2714G>A	c.(2713-2715)CGA>CAA	p.R905Q	FAM179B_uc001wvw.2_Missense_Mutation_p.R905Q|FAM179B_uc010anc.2_RNA|FAM179B_uc001wvu.2_Missense_Mutation_p.R905Q	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	905							binding			skin(2)|upper_aerodigestive_tract(1)	3						TCTTCCCGACGAGGTCTAAAT	0.423													26	85					0	0	0	0	A	45475280	A	A	45475280	3	1	303	1	0	0	0	0	1	0	0	0	5534	1058	37	1	2732	1	FAM179B	14	45475280	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	5679209	45475280	61874260	497	56024											
C14orf104	55172	broad.mit.edu	37	chr14	50101007	50101007	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gagcgcaacagcggcagttcGatggtgatcaccagctcatg	10	7	13	11	3	2	1	2	1	0	0	3	3	2	1	1	2	4	4	1	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:50101007G>C	uc001wws.3	-	1	942	c.861C>G	c.(859-861)ATC>ATG	p.I287M	SDCCAG1_uc010anj.1_Intron|C14orf104_uc001wwt.3_Missense_Mutation_p.I287M	NM_018139	NP_060609	Q9NVR5	KTU_HUMAN	kintoun isoform 1	287					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm					0	all_epithelial(31;0.0021)|Breast(41;0.0124)					GCGGCAGTTCGATGGTGATCA	0.657									Kartagener_syndrome				10	33					0	0	0	0	C	50101007	C	C	50101007	3	2	303	1	0	0	0	0	1	0	0	0	1742	1048	37	3	1664	3	C14orf104	14	50101007	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4625727	50101007	57248533	498	56025											
SOS2	6655	broad.mit.edu	37	chr14	50626418	50626418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttgtttttttcttcagcaGacttagcagcaaatattatg	11	17	7	6	0	2	1	1	0	1	1	2	1	2	1	0	0	3	5	0	0	4	8			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:50626418G>A	uc001wxs.3	-	10	1681	c.1583C>T	c.(1582-1584)TCT>TTT	p.S528F	SOS2_uc010tql.1_Missense_Mutation_p.S495F|SOS2_uc010tqm.1_RNA|SOS2_uc001wxt.2_Missense_Mutation_p.S216F	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	528	PH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					TTCTTCAGCAGACTTAGCAGC	0.328													18	55					0	0	0	0	A	50626418	A	A	50626418	3	1	303	1	0	0	0	0	1	0	0	0	15001	942	33	2	2471	2	SOS2	14	50626418	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	525411	50626418	56723122	499	56026											
PYGL	5836	broad.mit.edu	37	chr14	51381452	51381452	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tctgcaagtcctgggttgcaGagtaggagccagcgccttgg	7	9	15	10	1	1	1	0	0	1	1	2	2	2	2	3	3	4	4	3	3	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:51381452G>C	uc001wyu.2	-	12	1612	c.1485C>G	c.(1483-1485)CTC>CTG	p.L495L	PYGL_uc010tqq.1_Silent_p.L461L|PYGL_uc001wyv.2_Silent_p.L169L	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	495					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CTGGGTTGCAGAGTAGGAGCC	0.493													9	30					0	0	0	0	C	51381452	C	C	51381452	2	2	303	1	0	0	0	0	0	0	0	1	12926	929	33	2		2	PYGL	14	51381452	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	755034	51381452	55968088	500	56027											
C14orf39	317761	broad.mit.edu	37	chr14	60923756	60923756	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tggaaaattctcagctctctCttctacttcatcactatcat	10	16	3	12	0	7	0	4	0	4	0	9	1	7	1	0	1	2	1	0	1	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:60923756C>T	uc001xez.3	-	15	1347	c.1237G>A	c.(1237-1239)GAG>AAG	p.E413K	C14orf39_uc010apo.2_Missense_Mutation_p.E124K	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	413										ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		TCAGCTCTCTCTTCTACTTCA	0.353													30	60					0	0	0	0	T	60923756	T	T	60923756	3	4	303	1	0	0	0	0	1	0	0	0	1778	922	32	2	542	2	C14orf39	14	60923756	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	9542304	60923756	46425784	501	56028											
ZBTB1	22890	broad.mit.edu	37	chr14	64989937	64989937	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catcatggaagaaaatgaaaGagatcacagacgaaagcatt	20	6	9	6	1	2	4	2	1	0	3	2	7	2	5	0	1	1	1	0	1	5	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:64989937G>C	uc001xhh.3	+	4	2146	c.1715G>C	c.(1714-1716)AGA>ACA	p.R572T	ZBTB1_uc010aqg.2_Missense_Mutation_p.R572T|ZBTB1_uc001xhi.2_Missense_Mutation_p.R572T	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		GAAAATGAAAGAGATCACAGA	0.368													18	38					0	0	0	0	C	64989937	C	C	64989937	3	2	303	1	0	0	0	0	1	0	0	0	17589	942	33	2	1717	2	ZBTB1	14	64989937	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4066181	64989937	42359603	502	56029											
PCNX	22990	broad.mit.edu	37	chr14	71575426	71575426	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgctatagcagccggcattCatccctccggatgtccacca	8	9	8	16	2	1	0	1	0	0	0	4	1	4	1	5	2	3	3	5	2	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:71575426C>T	uc001xmo.2	+	34	6853	c.6407C>T	c.(6406-6408)TCA>TTA	p.S2136L	PCNX_uc010are.1_Missense_Mutation_p.S2025L|PCNX_uc010arf.1_Missense_Mutation_p.S924L|PCNX_uc001xmp.2_Missense_Mutation_p.S220L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	2136	Ser-rich.					integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AGCCGGCATTCATCCCTCCGG	0.572													31	63					0	0	0	0	T	71575426	T	T	71575426	3	4	303	1	0	0	0	0	1	0	0	0	11645	838	29	2	6541	2	PCNX	14	71575426	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6585489	71575426	35774114	503	56030											
ACOT2	10965	broad.mit.edu	37	chr14	74036030	74036030	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctcatctcctgctgtccttcGagcgtcccggctgtaccaat	5	12	8	16	3	2	0	1	0	1	0	6	1	4	0	4	1	3	3	4	1	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:74036030G>C	uc001xon.3	+	1	259	c.86G>C	c.(85-87)CGA>CCA	p.R29P	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_5'UTR	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	29					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		GCTGTCCTTCGAGCGTCCCGG	0.562													51	118					0	0	0	0	C	74036030	C	C	74036030	3	2	303	1	0	0	0	0	1	0	0	0	152	1058	37	3	88	3	ACOT2	14	74036030	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2460604	74036030	33313510	504	56031											
C14orf115	55237	broad.mit.edu	37	chr14	74824951	74824951	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gggcagggaatgccacaggtGaggaccctcccgcccccggg	7	3	16	15	2	0	1	0	1	0	0	1	3	1	3	5	5	1	1	5	5	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:74824951G>A	uc001xpw.3	+	2	1656	c.1465G>A	c.(1465-1467)GAG>AAG	p.E489K		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	489					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		TGCCACAGGTGAGGACCCTCC	0.662													28	56					0	0	0	0	A	74824951	A	A	74824951	3	1	303	1	0	0	0	0	1	0	0	0	1746	1291	45	2	1467	2	C14orf115	14	74824951	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	788921	74824951	32524589	505	56032											
YLPM1	56252	broad.mit.edu	37	chr14	75230935	75230935	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	atcccaactactagctccacCaccaccgtccgccccccctg	8	6	4	23	2	0	0	0	0	0	0	3	0	3	0	9	0	3	1	9	0	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:75230935C>T	uc001xqj.3	+	1	867	c.743C>T	c.(742-744)CCA>CTA	p.P248L		NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	88	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CTAGCTCCACCACCACCGTCC	0.557													23	37					0	0	0	0	T	75230935	T	T	75230935	3	4	303	1	0	0	0	0	1	0	0	0	17554	594	21	4	745	4	YLPM1	14	75230935	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	405984	75230935	32118605	506	56033											
C14orf118	55668	broad.mit.edu	37	chr14	76621147	76621147	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctagccttcagcagaagctGaaggtgtcagattggagcta	11	9	13	8	0	2	3	2	1	0	2	2	4	2	4	1	2	4	4	1	2	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:76621147G>A	uc001xsh.2	+	2	527	c.441G>A	c.(439-441)CTG>CTA	p.L147L	C14orf118_uc001xsi.2_Silent_p.L147L|C14orf118_uc001xsj.1_Silent_p.L147L|C14orf118_uc001xsk.1_Silent_p.L147L|C14orf118_uc001xsl.2_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	147										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		AGCAGAAGCTGAAGGTGTCAG	0.542													13	17					0	0	0	0	A	76621147	A	A	76621147	2	1	303	1	0	0	0	0	0	0	0	1	1747	1277	45	2		2	C14orf118	14	76621147	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1390212	76621147	30728393	507	56034											
GALC	2581	broad.mit.edu	37	chr14	88452837	88452837	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaacttcatttcttaccaatGagtgtaatattgggattcct	12	16	6	7	0	2	1	1	1	1	0	3	2	3	2	2	1	2	1	2	1	5	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:88452837G>A	uc001xvt.2	-	4	837	c.438C>T	c.(436-438)CTC>CTT	p.L146L	GALC_uc010tvx.1_Silent_p.L120L|GALC_uc010tvy.1_Silent_p.L123L|GALC_uc010tvz.1_Silent_p.L90L|GALC_uc001xvu.1_Silent_p.L146L	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	146					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						TCTTACCAATGAGTGTAATAT	0.373													9	16					0	0	0	0	A	88452837	A	A	88452837	2	1	303	1	0	0	0	0	0	0	0	1	6236	1277	45	2		2	GALC	14	88452837	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	11831690	88452837	18896703	508	56035											
LGMN	5641	broad.mit.edu	37	chr14	93179217	93179217	+	Splice_Site	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcttcaatgtagaacaccatCtgtgaggcagacggggcagg	11	7	14	9	1	2	3	1	1	1	2	2	3	2	3	1	4	1	4	1	4	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:93179217C>T	uc001yav.2	-	9	870	c.544_splice	c.e9-1	p.M182_splice	LGMN_uc001yat.2_Splice_Site_p.M182_splice|LGMN_uc001yau.2_Splice_Site_p.M182_splice|LGMN_uc001yaw.2_Splice_Site_p.M182_splice|LGMN_uc010aul.2_Splice_Site_p.M63_splice|LGMN_uc001yax.2_Splice_Site_p.M182_splice|LGMN_uc001yay.2_Splice_Site_p.M182_splice	NM_001008530	NP_001008530	Q99538	LGMN_HUMAN	legumain preproprotein						hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			skin(1)	1		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		AGAACACCATCTGTGAGGCAG	0.587													8	18					0	0	0	0	T	93179217	T	T	93179217	5	4	303	1	0	0	0	0	0	0	1	0	8796	927	32	2	786	2	LGMN	14	93179217	Splice_Site	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4726380	93179217	14170323	509	56036											
GOLGA5	9950	broad.mit.edu	37	chr14	93273116	93273116	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagattctagccatgaaggtCaagaggaatcttcaaaggaa	16	8	10	7	0	4	3	2	1	2	2	4	5	4	5	1	3	1	0	1	3	6	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:93273116C>T	uc001yaz.1	+	3	762	c.580C>T	c.(580-582)CAA>TAA	p.Q194*		NM_005113	NP_005104	Q8TBA6	GOGA5_HUMAN	Golgi autoantigen, golgin subfamily a, 5	194	Cytoplasmic (Potential).				Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			ovary(2)|lung(1)	3		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		CCATGAAGGTCAAGAGGAATC	0.408			T	RET	papillary thyroid								4	12					0	0	0	0	T	93273116	T	T	93273116	4	4	303	1	0	0	0	0	0	1	0	0	6593	827	29	2	586	2	GOLGA5	14	93273116	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	93899	93273116	14076424	510	56037											
FAM181A	90050	broad.mit.edu	37	chr14	94394950	94394950	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	tgaggaacccctacagggagGaatgtcttgctaaggagcag	12	7	14	8	0	1	1	0	1	1	0	1	5	1	5	2	4	4	2	2	4	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:94394950G>C	uc001ybz.1	+	3	812	c.505G>C	c.(505-507)GAA>CAA	p.E169Q	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Missense_Mutation_p.E107Q|FAM181A_uc001yca.1_Missense_Mutation_p.E107Q	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	169											0						CTACAGGGAGGAATGTCTTGC	0.642													10	35					0	0	0	0	C	94394950	C	C	94394950	3	2	303	1	0	0	0	0	1	0	0	0	5536	1175	41	2	511	2	FAM181A	14	94394950	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1121834	94394950	12954590	511	56038											
SERPINA10	51156	broad.mit.edu	37	chr14	94756481	94756481	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tccaggttgcgggagagggtCtctctgagtcccttaaagag	8	10	14	9	1	2	3	0	1	2	2	5	4	4	3	2	3	1	1	2	3	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:94756481C>G	uc001yct.2	-	2	916	c.450G>C	c.(448-450)GAG>GAC	p.E150D	SERPINA10_uc001ycu.3_Missense_Mutation_p.E150D	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	150					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		GGGAGAGGGTCTCTCTGAGTC	0.542													27	40					0	0	0	0	G	94756481	G	G	94756481	3	3	303	1	0	0	0	0	1	0	0	0	14152	912	32	2	900	2	SERPINA10	14	94756481	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	361531	94756481	12593059	512	56039											
ATG2B	55102	broad.mit.edu	37	chr14	96757999	96757999	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttaactgagccagaccaatCaaaatcccagctagcgtacc	14	8	6	13	1	1	2	1	1	0	1	2	2	2	2	4	0	5	2	4	0	6	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:96757999C>G	uc001yfi.2	-	38	5882	c.5517G>C	c.(5515-5517)TTG>TTC	p.L1839F		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1839										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CCAGACCAATCAAAATCCCAG	0.333													15	53					0	0	0	0	G	96757999	G	G	96757999	3	3	303	1	0	0	0	0	1	0	0	0	1096	825	29	2	739	2	ATG2B	14	96757999	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2001518	96757999	10591541	513	56040											
DLK1	8788	broad.mit.edu	37	chr14	101200978	101200978	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacaagaaaacccctctcctCaccgagggccaggccatctg	12	5	8	16	1	3	1	1	0	2	1	4	2	3	1	6	2	2	0	6	2	4	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:101200978C>T	uc001yhs.3	+	5	1050	c.897C>T	c.(895-897)CTC>CTT	p.L299L	DLK1_uc001yhu.3_Intron	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	299	Extracellular (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				CCCCTCTCCTCACCGAGGGCC	0.622													19	49					0	0	0	0	T	101200978	T	T	101200978	2	4	303	1	0	0	0	0	0	0	0	1	4586	813	29	2		2	DLK1	14	101200978	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4442979	101200978	6148562	514	56041											
DYNC1H1	1778	broad.mit.edu	37	chr14	102505826	102505826	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctatacgagaacccgaacctGaagggtgtcaccgaccacac	13	5	9	14	3	1	2	1	1	0	1	1	5	1	2	4	1	3	0	4	1	5	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:102505826G>A	uc001yks.2	+	61	11702	c.11538G>A	c.(11536-11538)CTG>CTA	p.L3846L		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3846					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						ACCCGAACCTGAAGGGTGTCA	0.542													19	31					0	0	0	0	A	102505826	A	A	102505826	2	1	303	1	0	0	0	0	0	0	0	1	4863	1277	45	2		2	DYNC1H1	14	102505826	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1304848	102505826	4843714	515	56042											
HSP90AA1	3320	broad.mit.edu	37	chr14	102551177	102551177	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttaatcttcttcttcttcttCttgtcaccatccttcttttc	4	23	1	13	0	8	0	1	0	7	0	10	0	9	0	2	0	0	0	2	0	1	10			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:102551177C>G	uc001yku.3	-	5	1012	c.822G>C	c.(820-822)AAG>AAC	p.K274N	HSP90AA1_uc001ykv.3_Missense_Mutation_p.K396N|HSP90AA1_uc001ykw.1_Missense_Mutation_p.K95N|HSP90AA1_uc001ykx.1_Missense_Mutation_p.K263N	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	274					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	tcttcttcttcttgtcaccat	0.229													4	15					0	0	0	0	G	102551177	G	G	102551177	3	3	303	1	0	0	0	0	1	0	0	0	7440	912	32	2	1404	2	HSP90AA1	14	102551177	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	45351	102551177	4798363	516	56043											
HSP90AA1	3320	broad.mit.edu	37	chr14	102551332	102551332	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	ttctttatcacgttccttctCcaccttcaaaagaaaacacg	12	13	3	13	2	4	1	2	0	2	1	6	1	5	1	3	0	1	1	3	0	5	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:102551332C>G	uc001yku.3	-	5	857	c.667G>C	c.(667-669)GAG>CAG	p.E223Q	HSP90AA1_uc001ykv.3_Missense_Mutation_p.E345Q|HSP90AA1_uc001ykw.1_Missense_Mutation_p.E44Q|HSP90AA1_uc001ykx.1_Missense_Mutation_p.E212Q	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	223					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CGTTCCTTCTCCACCTTCAAA	0.343													6	17					0	0	0	0	G	102551332	G	G	102551332	3	3	303	1	0	0	0	0	1	0	0	0	7440	864	30	2	1559	2	HSP90AA1	14	102551332	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	155	102551332	4798208	517	56044											
CDC42BPB	9578	broad.mit.edu	37	chr14	103406451	103406451	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ggaggttgagggtgccttcaGagttcaggggccttatctgg	6	11	17	7	0	3	2	2	1	1	1	3	3	3	3	2	6	1	2	2	6	1	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:103406451G>A	uc001ymi.1	-	32	4755	c.4523C>T	c.(4522-4524)TCT>TTT	p.S1508F		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1508	CNH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GGTGCCTTCAGAGTTCAGGGG	0.617													10	26					0	0	0	0	A	103406451	A	A	103406451	3	1	303	1	0	0	0	0	1	0	0	0	3088	942	33	2	636	2	CDC42BPB	14	103406451	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	855119	103406451	3943089	518	56045											
MARK3	4140	broad.mit.edu	37	chr14	103932719	103932719	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggatcaatgcagggcatgaaGaagatgaactcaaaccattt	16	8	10	7	0	2	4	2	2	0	2	2	5	2	5	1	2	3	2	1	2	5	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:103932719G>C	uc001ymz.3	+	10	1603	c.937G>C	c.(937-939)GAA>CAA	p.E313Q	MARK3_uc001ymx.3_Missense_Mutation_p.E313Q|MARK3_uc001ymw.3_Missense_Mutation_p.E313Q|MARK3_uc001yna.3_Missense_Mutation_p.E313Q|MARK3_uc001ymy.3_Missense_Mutation_p.E234Q|MARK3_uc010awp.2_Missense_Mutation_p.E336Q|MARK3_uc010tyb.1_Missense_Mutation_p.E124Q	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	313							ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)			AGGGCATGAAGAAGATGAACT	0.363													8	13					0	0	0	0	C	103932719	C	C	103932719	3	2	303	1	0	0	0	0	1	0	0	0	9367	943	33	2	975	2	MARK3	14	103932719	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	526268	103932719	3416821	519	56046											
TRMT61A	115708	broad.mit.edu	37	chr14	103999011	103999011	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agttccaccagcagcgggcaGagaaggcccgggaggagttc	10	4	16	11	2	0	1	0	0	0	1	2	4	1	3	3	4	2	4	3	4	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:103999011G>A	uc001yng.2	+	3	543	c.424G>A	c.(424-426)GAG>AAG	p.E142K	TRMT61A_uc010aws.2_5'UTR	NM_152307	NP_689520	Q96FX7	TRM61_HUMAN	tRNA(m1A58)-methyltransferase subunit TRM61	142						nucleus	protein binding|tRNA (adenine-N1-)-methyltransferase activity				0						GCAGCGGGCAGAGAAGGCCCG	0.682													7	29					0	0	0	0	A	103999011	A	A	103999011	3	1	303	1	0	0	0	0	1	0	0	0	16636	943	33	2	430	2	TRMT61A	14	103999011	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	66292	103999011	3350529	520	56047											
PPP1R13B	23368	broad.mit.edu	37	chr14	104205238	104205238	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcacctcatagatgatcctCtgcaccagatcgaactctcc	10	10	5	16	1	4	3	2	1	2	2	7	4	5	3	4	0	2	1	4	0	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:104205238C>T	uc001yof.1	-	13	2998	c.2715G>A	c.(2713-2715)CAG>CAA	p.Q905Q	PPP1R13B_uc010awv.1_RNA	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	905					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				AGATGATCCTCTGCACCAGAT	0.642													41	140					0	0	0	0	T	104205238	T	T	104205238	2	4	303	1	0	0	0	0	0	0	0	1	12417	912	32	2		2	PPP1R13B	14	104205238	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	206227	104205238	3144302	521	56048											
ASPG	374569	broad.mit.edu	37	chr14	104571013	104571013	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgacatcggaggccgccCtggccaagctatcgtatgtg	9	8	12	12	3	0	1	0	1	0	0	2	2	0	2	3	3	1	2	3	3	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:104571013C>G	uc001yoq.1	+	9	1051	c.991C>G	c.(991-993)CTG>GTG	p.L331V	ASPG_uc001yoo.1_Missense_Mutation_p.L359V|ASPG_uc001yop.1_Missense_Mutation_p.L331V|ASPG_uc001yor.1_Missense_Mutation_p.L331V	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	331	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						GGAGGCCGCCCTGGCCAAGCT	0.682													19	20					0	0	0	0	G	104571013	G	G	104571013	3	3	303	1	0	0	0	0	1	0	0	0	1054	680	24	4	1025	4	ASPG	14	104571013	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	365775	104571013	2778527	522	56049											
AHNAK2	113146	broad.mit.edu	37	chr14	105409745	105409745	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agggggctgaacgctgaggtCagtggccttgaggtccccct	6	8	16	11	1	1	3	1	3	0	0	2	3	2	3	3	5	1	2	3	5	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:105409745C>T	uc010axc.1	-	7	12163	c.12043G>A	c.(12043-12045)GAC>AAC	p.D4015N	AHNAK2_uc001ypx.2_Missense_Mutation_p.D3915N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4015						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACGCTGAGGTCAGTGGCCTTG	0.657													39	97					0	0	0	0	T	105409745	T	T	105409745	3	4	303	1	0	0	0	0	1	0	0	0	415	826	29	2	5348	2	AHNAK2	14	105409745	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	838732	105409745	1939795	523	56050											
AHNAK2	113146	broad.mit.edu	37	chr14	105410277	105410277	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccctgcatggaggggagactCacatcggcctccaccttggg	7	7	13	14	1	1	1	1	0	0	1	3	3	2	2	4	5	1	1	4	5	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:105410277C>G	uc010axc.1	-	7	11631	c.11511G>C	c.(11509-11511)GTG>GTC	p.V3837V	AHNAK2_uc001ypx.2_Silent_p.V3737V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3837						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGGGGAGACTCACATCGGCCT	0.592													49	133					0	0	0	0	G	105410277	G	G	105410277	2	3	303	1	0	0	0	0	0	0	0	1	415	813	29	2		2	AHNAK2	14	105410277	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	532	105410277	1939263	524	56051											
AHNAK2	113146	broad.mit.edu	37	chr14	105411033	105411033	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttctgccttggggcctttCaggtccagcttggggccctt	3	13	12	13	0	2	0	1	0	1	0	3	0	3	0	4	5	2	1	4	5	0	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:105411033C>G	uc010axc.1	-	7	10875	c.10755G>C	c.(10753-10755)CTG>CTC	p.L3585L	AHNAK2_uc001ypx.2_Silent_p.L3485L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3585						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGGGGCCTTTCAGGTCCAGCT	0.602													36	71					0	0	0	0	G	105411033	G	G	105411033	2	3	303	1	0	0	0	0	0	0	0	1	415	813	29	2		2	AHNAK2	14	105411033	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	756	105411033	1938507	525	56052											
BRF1	2972	broad.mit.edu	37	chr14	105692409	105692409	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggcacagtggactcaccatCttttgccaggctggccaggc	7	8	13	13	0	2	0	1	0	1	0	2	1	2	1	3	5	1	2	3	5	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr14:105692409C>G	uc001yqp.2	-	10	1408	c.1045G>C	c.(1045-1047)GAT>CAT	p.D349H	BRF1_uc010tyo.1_Missense_Mutation_p.D234H|BRF1_uc010typ.1_Missense_Mutation_p.D234H|BRF1_uc001yql.2_Missense_Mutation_p.D145H|BRF1_uc001yqo.2_Missense_Mutation_p.D111H|BRF1_uc010axg.1_Missense_Mutation_p.D322H|BRF1_uc001yqn.2_Intron|BRF1_uc010axh.1_Intron	NM_001519	NP_001510	Q92994	TF3B_HUMAN	transcription initiation factor IIIB isoform 1	349					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		GACTCACCATCTTTTGCCAGG	0.343													15	48					0	0	0	0	G	105692409	G	G	105692409	3	3	303	1	0	0	0	0	1	0	0	0	1515	913	32	2	1024	2	BRF1	14	105692409	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	281376	105692409	1657131	526	56053											
OR4M2	390538	broad.mit.edu	37	chr15	22369149	22369149	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccggattgcctgtgccaacAccttcccagaggagttagtg	8	10	11	12	1	0	1	0	0	0	1	2	3	2	3	5	2	3	1	5	2	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:22369149A>G	uc010tzu.1	+	1	574	c.574A>G	c.(574-576)ACC>GCC	p.T192A	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTGTGCCAACACCTTCCCAGA	0.478													24	100					0	0	0	0	G	22369149	G	G	22369149	3	3	303	1	0	0	0	0	1	0	0	0	11130	159	6	5	576	5	OR4M2	15	22369149	Missense_Mutation	SNP	A	TCGA-HL-7533-01A-11D-2229-08		22369149	80162243	527	56054											
CYFIP1	23191	broad.mit.edu	37	chr15	22933613	22933613	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacagtccatccaggaatcgCagaatctgtccatgttcctg	10	10	8	13	1	1	1	0	0	1	1	6	2	5	2	4	1	0	2	4	1	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:22933613C>T	uc001yus.2	+	7	726	c.622C>T	c.(622-624)CAG>TAG	p.Q208*	CYFIP1_uc001yut.2_Nonsense_Mutation_p.Q208*|CYFIP1_uc010aya.1_Nonsense_Mutation_p.Q236*	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	208					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CCAGGAATCGCAGAATCTGTC	0.502													9	16					0	0	0	0	T	22933613	T	T	22933613	4	4	303	1	0	0	0	0	0	1	0	0	4154	711	25	4	644	4	CYFIP1	15	22933613	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	564464	22933613	79597779	528	56055											
HERC2	8924	broad.mit.edu	37	chr15	28359761	28359761	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gacggatgaccaccaacctaTagtttatcgccagccgcacg	11	7	9	14	4	0	1	0	1	0	0	1	3	0	2	5	1	2	2	5	1	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:28359761T>C	uc001zbj.2	-	90	14016	c.13910A>G	c.(13909-13911)TAT>TGT	p.Y4637C	HERC2_uc001zbi.2_Missense_Mutation_p.Y326C	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4637	HECT.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CACCAACCTATAGTTTATCGC	0.502													8	37					0	0	0	0	C	28359761	C	C	28359761	3	2	303	1	0	0	0	0	1	0	0	0	7097	1406	49	5	610	5	HERC2	15	28359761	Missense_Mutation	SNP	T	TCGA-HL-7533-01A-11D-2229-08	5426148	28359761	74171631	529	56056											
HERC2	8924	broad.mit.edu	37	chr15	28380685	28380685	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaagagtaaacttctccttCtgaagacagggcaaggcagt	13	8	10	10	0	2	3	0	1	2	2	3	3	2	3	2	2	1	3	2	2	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:28380685C>T	uc001zbj.2	-	79	12275	c.12169G>A	c.(12169-12171)GAA>AAA	p.E4057K		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4057					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ACTTCTCCTTCTGAAGACAGG	0.438													37	108					0	0	0	0	T	28380685	T	T	28380685	3	4	303	1	0	0	0	0	1	0	0	0	7097	922	32	2	2395	2	HERC2	15	28380685	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	20924	28380685	74150707	530	56057											
ZNF770	54989	broad.mit.edu	37	chr15	35275626	35275626	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagcatttttaaattgttttCagccatcatattcttcaatg	11	19	4	7	0	4	0	3	0	1	0	4	0	4	0	1	0	2	2	1	0	5	10			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:35275626C>T	uc001ziw.2	-	3	321	c.10G>A	c.(10-12)GAA>AAA	p.E4K		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		AAATTGTTTTCAGCCATCATA	0.294													8	27					0	0	0	0	T	35275626	T	T	35275626	3	4	303	1	0	0	0	0	1	0	0	0	18210	835	29	2	2069	2	ZNF770	15	35275626	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6894941	35275626	67255766	531	56058											
FSIP1	161835	broad.mit.edu	37	chr15	40068691	40068691	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttgaatttgaagctggttttGaaattccatctaggtttccc	9	17	8	7	0	1	3	0	3	1	0	3	3	3	3	2	2	1	3	2	2	4	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:40068691G>C	uc001zki.2	-	2	253	c.35C>G	c.(34-36)TCA>TGA	p.S12*		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	12										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		AGCTGGTTTTGAAATTCCATC	0.353													9	40					0	0	0	0	C	40068691	C	C	40068691	4	2	303	1	0	0	0	0	0	1	0	0	6108	1294	45	2	1754	2	FSIP1	15	40068691	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4793065	40068691	62462701	532	56059											
CDAN1	146059	broad.mit.edu	37	chr15	43017724	43017724	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgccagaagccccacatttCttgggctcagcagcagctgc	8	8	10	15	0	2	1	1	0	1	1	2	1	2	1	3	1	6	4	3	1	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:43017724C>G	uc001zql.2	-	26	3530	c.3413G>C	c.(3412-3414)AGA>ACA	p.R1138T	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Missense_Mutation_p.R464T	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	1138						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CCCCACATTTCTTGGGCTCAG	0.587													16	56					0	0	0	0	G	43017724	G	G	43017724	3	3	303	1	0	0	0	0	1	0	0	0	3069	913	32	2	282	2	CDAN1	15	43017724	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2949033	43017724	59513668	533	56060											
CDAN1	146059	broad.mit.edu	37	chr15	43022882	43022882	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaggagagaaactccacCagccagggcacggtgagcac	14	2	13	12	1	0	2	0	1	0	1	1	4	1	3	3	3	3	3	3	3	2	0	rs148759214		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:43022882C>T	uc001zql.2	-	14	2205	c.2088G>A	c.(2086-2088)CTG>CTA	p.L696L	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Nonsense_Mutation_p.W22*	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	696						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		GAAACTCCACCAGCCAGGGCA	0.632													5	14					0	0	0	0	T	43022882	T	T	43022882	2	4	303	1	0	0	0	0	0	0	0	1	3069	581	21	4		4	CDAN1	15	43022882	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5158	43022882	59508510	534	56061											
CDAN1	146059	broad.mit.edu	37	chr15	43022925	43022925	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cccggcgggcctgcagccctCgctgcagcagagtccgcaca	6	4	13	18	4	0	1	0	0	0	1	2	1	1	1	4	2	4	5	4	2	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:43022925C>T	uc001zql.2	-	14	2162	c.2045G>A	c.(2044-2046)CGA>CAA	p.R682Q	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Missense_Mutation_p.E8K	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	682						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CTGCAGCCCTCGCTGCAGCAG	0.637													3	6					0	0	0	0	T	43022925	T	T	43022925	3	4	303	1	0	0	0	0	1	0	0	0	3069	884	31	1	1698	1	CDAN1	15	43022925	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	43	43022925	59508467	535	56062											
MAP1A	4130	broad.mit.edu	37	chr15	43814521	43814521	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggagggcctagaaaagcttCggcatctggacttcctgcgt	8	10	13	10	2	1	1	0	0	1	1	3	3	2	3	2	4	2	2	2	4	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:43814521C>T	uc001zrt.2	+	4	1317	c.850C>T	c.(850-852)CGG>TGG	p.R284W		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	284						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGAAAAGCTTCGGCATCTGGA	0.552													13	23					0	0	0	0	T	43814521	T	T	43814521	3	4	303	1	0	0	0	0	1	0	0	0	9280	875	31	1	852	1	MAP1A	15	43814521	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	791596	43814521	58716871	536	56063											
MAP1A	4130	broad.mit.edu	37	chr15	43821418	43821418	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atgtgtgcatggctgaccccGaggggctcagctcagagtct	7	9	14	11	1	3	2	2	1	1	1	3	3	3	2	2	3	2	4	2	3	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:43821418G>A	uc001zrt.2	+	4	8214	c.7747G>A	c.(7747-7749)GAG>AAG	p.E2583K		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2583						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGCTGACCCCGAGGGGCTCAG	0.667													16	37					0	0	0	0	A	43821418	A	A	43821418	3	1	303	1	0	0	0	0	1	0	0	0	9280	1059	37	1	7749	1	MAP1A	15	43821418	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	6897	43821418	58709974	537	56064											
SECISBP2L	9728	broad.mit.edu	37	chr15	49319637	49319637	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttttccatccaaggttttttCtgagttgcctggcaagttac	7	17	8	9	0	1	1	0	1	1	0	3	1	3	1	3	2	2	4	3	2	3	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:49319637C>G	uc001zxe.1	-	7	1094	c.960G>C	c.(958-960)CAG>CAC	p.Q320H	SECISBP2L_uc001zxd.1_Missense_Mutation_p.Q320H|SECISBP2L_uc010bep.1_Missense_Mutation_p.Q82H|SECISBP2L_uc010beq.1_Missense_Mutation_p.Q237H	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	320										breast(1)|skin(1)	2						AAGGTTTTTTCTGAGTTGCCT	0.308													18	51					0	0	0	0	G	49319637	G	G	49319637	3	3	303	1	0	0	0	0	1	0	0	0	14072	912	32	2	2254	2	SECISBP2L	15	49319637	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5498219	49319637	53211755	538	56065											
ONECUT1	3175	broad.mit.edu	37	chr15	53081071	53081071	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cggccggatttgagtttgctCcagggtttggggttgcgcag	4	12	17	8	3	0	1	0	1	0	0	1	2	1	2	2	5	2	5	2	5	0	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:53081071C>A	uc002aci.1	-	1	1139	c.1011G>T	c.(1009-1011)TGG>TGT	p.W337C		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	337	CUT.				endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		TGAGTTTGCTCCAGGGTTTGG	0.647													16	31					3.52763e-06	3.59311e-06	1	0	A	53081071	A	A	53081071	3	1	303	1	0	0	0	0	1	0	0	0	10922	856	30	2	394	2	ONECUT1	15	53081071	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3761434	53081071	49450321	539	56066											
LRRC49	54839	broad.mit.edu	37	chr15	71193302	71193302	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gctcatcattgtcatcatttCctattcttcaacgttcttct	7	19	3	12	1	8	0	5	0	3	0	9	0	9	0	1	0	1	2	1	0	2	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:71193302C>T	uc002asw.2	+	4	482	c.235C>T	c.(235-237)CCT>TCT	p.P79S	LRRC49_uc002asu.2_Missense_Mutation_p.P69S|LRRC49_uc002asx.2_Missense_Mutation_p.P35S|LRRC49_uc010ukf.1_Missense_Mutation_p.P84S|LRRC49_uc002asy.2_5'UTR|LRRC49_uc002asz.2_Missense_Mutation_p.P51S	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	79						cytoplasm|microtubule				ovary(1)	1						GTCATCATTTCCTATTCTTCA	0.308													15	23					0	0	0	0	T	71193302	T	T	71193302	3	4	303	1	0	0	0	0	1	0	0	0	9056	855	30	2	249	2	LRRC49	15	71193302	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	18112231	71193302	31338090	540	56067											
NRG4	145957	broad.mit.edu	37	chr15	76248315	76248315	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cgtctctaccaggttgatatCatactggactgaactggctc	9	12	9	11	1	2	2	1	2	1	0	4	3	2	3	1	3	3	2	1	3	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:76248315C>T	uc002bbo.2	-	5	473	c.289G>A	c.(289-291)GAT>AAT	p.D97N	NRG4_uc010bkm.1_RNA|NRG4_uc002bbn.2_RNA|NRG4_uc010bkn.2_RNA|NRG4_uc010bko.2_RNA	NM_138573	NP_612640	Q8WWG1	NRG4_HUMAN	neuregulin 4	97	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane	growth factor activity				0						AGGTTGATATCATACTGGACT	0.408													16	30					0	0	0	0	T	76248315	T	T	76248315	3	4	303	1	0	0	0	0	1	0	0	0	10704	826	29	2	66	2	NRG4	15	76248315	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5055013	76248315	26283077	541	56068											
WDR61	80349	broad.mit.edu	37	chr15	78581964	78581964	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	aagatgatgatatataccttCcagggtatgcagaagttttc	13	13	9	6	0	0	4	0	2	0	2	2	4	1	4	2	1	2	3	2	1	6	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:78581964C>T	uc002bdn.2	-	7	635	c.559G>A	c.(559-561)GAA>AAA	p.E187K	WDR61_uc002bdo.2_Missense_Mutation_p.E187K	NM_025234	NP_079510	Q9GZS3	WDR61_HUMAN	WD repeat domain 61	187	WD 4.						protein binding			ovary(1)|skin(1)	2						TATATACCTTCCAGGGTATGC	0.363													12	28					0	0	0	0	T	78581964	T	T	78581964	3	4	303	1	0	0	0	0	1	0	0	0	17380	864	30	2	378	2	WDR61	15	78581964	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2333649	78581964	23949428	542	56069											
FAM154B	283726	broad.mit.edu	37	chr15	82575232	82575232	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctttaaatattgcttttaaGagttctgttccatttgatga	10	19	6	6	0	1	3	0	2	1	1	2	3	2	3	2	0	1	3	2	0	4	9			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:82575232G>T	uc002bgv.2	+	3	1095	c.1026G>T	c.(1024-1026)AAG>AAT	p.K342N	FAM154B_uc010unr.1_Missense_Mutation_p.K327N|FAM154B_uc010uns.1_RNA	NM_001008226	NP_001008227	Q658L1	F154B_HUMAN	hypothetical protein LOC283726	342										skin(2)	2						TTGCTTTTAAGAGTTCTGTTC	0.403													8	27					0.00307968	0.00309377	1	0	T	82575232	T	T	82575232	3	4	303	1	0	0	0	0	1	0	0	0	5492	933	33	2	1036	2	FAM154B	15	82575232	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3993268	82575232	19956160	543	56070											
ZNF592	9640	broad.mit.edu	37	chr15	85327563	85327563	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggctgccccactgattgtaGaggtcttcaacaaggtcctt	9	11	10	11	0	2	2	1	1	1	1	3	2	3	2	3	3	2	2	3	3	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:85327563G>A	uc002bld.2	+	4	1993	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	553					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ACTGATTGTAGAGGTCTTCAA	0.592													21	61					0	0	0	0	A	85327563	A	A	85327563	3	1	303	1	0	0	0	0	1	0	0	0	18089	943	33	2	1659	2	ZNF592	15	85327563	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2752331	85327563	17203829	544	56071											
KIF7	374654	broad.mit.edu	37	chr15	90172735	90172735	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtacaccagcctctgctgctCctccagctgcatctccagtt	6	11	7	17	0	2	0	0	0	2	0	5	0	4	0	5	0	6	6	5	0	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:90172735C>T	uc002bof.2	-	17	3465	c.3388G>A	c.(3388-3390)GAG>AAG	p.E1130K	KIF7_uc010upw.1_Missense_Mutation_p.E616K|C15orf42_uc010upv.1_RNA	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	1130	Potential.				microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CTCTGCTGCTCCTCCAGCTGC	0.647													32	110					0	0	0	0	T	90172735	T	T	90172735	3	4	303	1	0	0	0	0	1	0	0	0	8348	864	30	2	655	2	KIF7	15	90172735	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4845172	90172735	12358657	545	56072											
TTLL13	440307	broad.mit.edu	37	chr15	90801269	90801269	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tctgagcactgggcctcgcaGgaagctgtcgacactcaaca	10	7	11	13	2	2	1	1	1	1	0	4	3	2	2	1	2	3	3	1	2	2	0	rs146502095		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:90801269G>A	uc002bpd.1	+	9	1224	c.936_splice	c.e9-1	p.R312_splice	TTLL13_uc002bpe.1_Intron	NM_001029964	NP_001025135	A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13						protein modification process		ATP binding|tubulin-tyrosine ligase activity				0	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			GGGCCTCGCAGGAAGCTGTCG	0.572													7	21					0	0	0	0	A	90801269	A	A	90801269	5	1	303	1	0	0	0	0	0	0	1	0	16794	1014	35	4	965	4	TTLL13	15	90801269	Splice_Site	SNP	G	TCGA-HL-7533-01A-11D-2229-08	628534	90801269	11730123	546	56073											
SV2B	9899	broad.mit.edu	37	chr15	91795215	91795215	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccttcctcttctgccgactCatctcaggcatcgggtatgt	5	13	9	14	2	4	0	2	0	3	0	7	1	5	0	3	2	1	2	3	2	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:91795215C>T	uc002bqv.2	+	2	1009	c.618C>T	c.(616-618)CTC>CTT	p.L206L	SV2B_uc002bqt.2_Silent_p.L206L|SV2B_uc010uqv.1_Silent_p.L55L|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	206	Helical; (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TCTGCCGACTCATCTCAGGCA	0.547													13	60					0	0	0	0	T	91795215	T	T	91795215	2	4	303	1	0	0	0	0	0	0	0	1	15484	813	29	2		2	SV2B	15	91795215	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	993946	91795215	10736177	547	56074											
TARSL2	123283	broad.mit.edu	37	chr15	102252183	102252183	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catggcctccccaagaatgtGagcactggagtgccagtaca	11	7	11	12	0	0	2	0	1	0	1	1	3	1	3	4	2	3	2	4	2	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr15:102252183G>C	uc002bxm.2	-	5	767	c.712C>G	c.(712-714)CAC>GAC	p.H238D	TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	238					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCAAGAATGTGAGCACTGGAG	0.443													7	19					0	0	0	0	C	102252183	C	C	102252183	3	2	303	1	0	0	0	0	1	0	0	0	15627	1290	45	2	1756	2	TARSL2	15	102252183	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10456968	102252183	279209	548	56075											
MSLNL	401827	broad.mit.edu	37	chr16	819431	819431	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggtaggttggcctggcctaGagctggcccgtcagcccaag	6	7	16	12	1	1	1	1	0	0	1	1	1	1	1	4	5	2	3	4	5	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:819431G>C	uc002cjz.1	-	16	3159	c.3159C>G	c.(3157-3159)CTC>CTG	p.L1053L	MIR662_hsa-mir-662|MI0003670_5'Flank	NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	702	Cytoplasmic (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						GCCTGGCCTAGAGCTGGCCCG	0.637													11	40					0	0	0	0	C	819431	C	C	819431	2	2	303	1	0	0	0	0	0	0	0	1	9935	929	33	2		2	MSLNL	16	819431	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08		819431	89535322	549	56076											
PTX4	390667	broad.mit.edu	37	chr16	1537722	1537722	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ggcccgctgctggctcctctCgcccagggtgaggtccaagg	4	7	15	15	2	1	1	0	1	1	0	4	1	3	1	4	5	1	3	4	5	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:1537722C>T	uc010uvf.1	-	2	376	c.376G>A	c.(376-378)GAG>AAG	p.E126K		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	131						extracellular region	metal ion binding				0						TGGCTCCTCTCGCCCAGGGTG	0.701													9	27					0	0	0	0	T	1537722	T	T	1537722	3	4	303	1	0	0	0	0	1	0	0	0	12888	893	31	1	1052	1	PTX4	16	1537722	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	718291	1537722	88817031	550	56077											
HS3ST6	64711	broad.mit.edu	37	chr16	1962146	1962146	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cggggggcctctcgcgtcacGaagtagctgggggtcttctc	4	9	16	12	4	4	0	1	0	3	0	6	1	4	0	1	5	1	2	1	5	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:1962146G>A	uc002cnf.2	-	2	381	c.381C>T	c.(379-381)TTC>TTT	p.F127F		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	127											0						CTCGCGTCACGAAGTAGCTGG	0.677													7	11					0	0	0	0	A	1962146	A	A	1962146	2	1	303	1	0	0	0	0	0	0	0	1	7408	1049	37	1		1	HS3ST6	16	1962146	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	424424	1962146	88392607	551	56078											
CASKIN1	57524	broad.mit.edu	37	chr16	2228626	2228626	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tcgtccaggatgctgccagtGctcttttccgccgccgagtc	4	11	11	15	4	1	0	0	0	1	0	5	2	3	1	5	1	3	2	5	1	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:2228626G>A	uc010bsg.1	-	20	4253	c.4221C>T	c.(4219-4221)AGC>AGT	p.S1407S		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	1407					signal transduction	cytoplasm				skin(2)	2						TGCTGCCAGTGCTCTTTTCCG	0.617													9	37					0	0	0	0	A	2228626	A	A	2228626	2	1	303	1	0	0	0	0	0	0	0	1	2678	1310	46	4		4	CASKIN1	16	2228626	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	266480	2228626	88126127	552	56079											
AMDHD2	51005	broad.mit.edu	37	chr16	2580409	2580409	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtggcaaacacgggccgtGaggctccctgaacagcttcg	9	7	13	12	3	0	2	0	2	0	0	2	2	1	2	2	3	3	3	2	3	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:2580409G>T	uc010uwc.1	+	11	1531	c.1434G>T	c.(1432-1434)GTG>GTT	p.V478V	AMDHD2_uc010uwd.1_Silent_p.V242V|CEMP1_uc002cqr.2_Silent_p.L222L	NM_001145815	NP_001139287	Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2 isoform 2	Error:Variant_position_missing_in_Q9Y303_after_alignment					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			skin(2)|large_intestine(1)|breast(1)	4						CACGGGCCGTGAGGCTCCCTG	0.632													9	33					1.12685e-05	1.14511e-05	1	0	T	2580409	T	T	2580409	2	4	303	1	0	0	0	0	0	0	0	1	568	1277	45	2		2	AMDHD2	16	2580409	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	351783	2580409	87774344	553	56080											
ZNF263	10127	broad.mit.edu	37	chr16	3340070	3340070	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agcgaccttataagtgtcccGagtgtgggaaaagtttctct	10	12	11	8	2	1	0	0	0	1	0	3	3	2	1	2	1	1	1	2	1	4	3	rs142452283		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:3340070G>A	uc002cuq.2	+	6	1896	c.1564G>A	c.(1564-1566)GAG>AAG	p.E522K	ZNF263_uc010uww.1_Missense_Mutation_p.E170K|ZNF263_uc002cur.2_Missense_Mutation_p.E170K	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	522	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						TAAGTGTCCCGAGTGTGGGAA	0.512													10	23					0	0	0	0	A	3340070	A	A	3340070	3	1	303	1	0	0	0	0	1	0	0	0	17870	1059	37	1	1586	1	ZNF263	16	3340070	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	759661	3340070	87014683	554	56081											
NLRC3	197358	broad.mit.edu	37	chr16	3614248	3614248	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtgcaggccacggtgttggaGaagtccagaggcgtcctgca	8	7	16	10	2	0	2	0	0	0	2	2	3	2	2	3	4	2	3	3	4	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:3614248G>A	uc010btn.2	-	5	1101	c.690C>T	c.(688-690)TTC>TTT	p.F230F		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	230	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CGGTGTTGGAGAAGTCCAGAG	0.622													5	15					0	0	0	0	A	3614248	A	A	3614248	2	1	303	1	0	0	0	0	0	0	0	1	10522	933	33	2		2	NLRC3	16	3614248	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	274178	3614248	86740505	555	56082											
PPL	5493	broad.mit.edu	37	chr16	4944533	4944533	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaacacacggccggagcaatCagcttgttcccagcgctgtc	10	7	10	14	3	1	0	1	0	0	0	3	1	2	1	2	2	4	4	2	2	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:4944533C>T	uc002cyd.1	-	12	1419	c.1329G>A	c.(1327-1329)CTG>CTA	p.L443L		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	443	Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						CCGGAGCAATCAGCTTGTTCC	0.637													24	56					0	0	0	0	T	4944533	T	T	4944533	2	4	303	1	0	0	0	0	0	0	0	1	12394	813	29	2		2	PPL	16	4944533	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1330285	4944533	85410220	556	56083											
GRIN2A	2903	broad.mit.edu	37	chr16	9892210	9892210	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttctgaagggcaattccataAccggtggtggcaaagatgta	12	10	12	7	1	1	2	0	1	1	1	2	2	2	2	2	4	1	3	2	4	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:9892210A>C	uc002czo.3	-	11	2828	c.2280T>G	c.(2278-2280)GGT>GGG	p.G760G	GRIN2A_uc010uym.1_Silent_p.G760G|GRIN2A_uc010uyn.1_Silent_p.G603G|GRIN2A_uc002czr.3_Silent_p.G760G	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	760	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CAATTCCATAACCGGTGGTGG	0.542													10	29					0	0	0	0	C	9892210	C	C	9892210	2	2	303	1	0	0	0	0	0	0	0	1	6818	30	2	5		5	GRIN2A	16	9892210	Silent	SNP	A	TCGA-HL-7533-01A-11D-2229-08	4947677	9892210	80462543	557	56084											
ERCC4	2072	broad.mit.edu	37	chr16	14028072	14028072	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caaaaaaggaactggtcctaGaaagcaacccaaagtgggag	18	4	11	8	0	0	1	0	0	0	1	1	3	1	3	2	3	3	1	2	3	8	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:14028072G>C	uc002dce.2	+	7	1135	c.1126G>C	c.(1126-1128)GAA>CAA	p.E376Q	ERCC4_uc010uyz.1_5'UTR	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	376					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						ACTGGTCCTAGAAAGCAACCC	0.363			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				18	38					0	0	0	0	C	14028072	C	C	14028072	3	2	303	1	0	0	0	0	1	0	0	0	5239	943	33	2	1152	2	ERCC4	16	14028072	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4135862	14028072	76326681	558	56085											
TMC7	79905	broad.mit.edu	37	chr16	19027907	19027907	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagctgtggcgggaggacatCcgcagcatagaaggtatgct	10	7	16	8	2	0	1	0	0	0	1	1	4	1	3	1	4	3	5	1	4	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:19027907C>G	uc002dfq.2	+	3	577	c.447C>G	c.(445-447)ATC>ATG	p.I149M	TMC7_uc010vao.1_Missense_Mutation_p.I149M|TMC7_uc002dfp.2_Missense_Mutation_p.I149M|TMC7_uc010vap.1_Missense_Mutation_p.I39M	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	149	Extracellular (Potential).					integral to membrane				skin(2)|ovary(1)	3						GGGAGGACATCCGCAGCATAG	0.458													16	28					0	0	0	0	G	19027907	G	G	19027907	3	3	303	1	0	0	0	0	1	0	0	0	16056	845	30	2	457	2	TMC7	16	19027907	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4999835	19027907	71326846	559	56086											
ACSM5	54988	broad.mit.edu	37	chr16	20451748	20451748	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagtcaggagtgggggaaatGaggtgcaccccaggaaggcc	12	4	17	8	0	1	1	1	1	0	0	1	4	1	4	3	6	1	1	3	6	3	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:20451748G>C	uc002dhe.2	+	14	1886	c.1739G>C	c.(1738-1740)TGA>TCA	p.*580S		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	580					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TGGGGGAAATGAGGTGCACCC	0.507													6	18					0	0	0	0	C	20451748	C	C	20451748	4	2	303	1	0	0	0	0	0	0	0	0	187	1285	45	2	1789	2	ACSM5	16	20451748	Nonstop_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1423841	20451748	69903005	560	56087											
ACSM2B	348158	broad.mit.edu	37	chr16	20563504	20563504	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcaaactttggcaagagatGaacaaatgtgcatgctccta	14	10	9	8	0	1	2	1	1	0	1	2	3	2	2	1	1	4	3	1	1	5	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:20563504G>C	uc002dhj.3	-	7	1066	c.856C>G	c.(856-858)CAT>GAT	p.H286D	ACSM2B_uc002dhk.3_Missense_Mutation_p.H286D|ACSM2B_uc010bwf.1_Missense_Mutation_p.H286D	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	286					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GGCAAGAGATGAACAAATGTG	0.433													40	86					0	0	0	0	C	20563504	C	C	20563504	3	2	303	1	0	0	0	0	1	0	0	0	184	1290	45	2	913	2	ACSM2B	16	20563504	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	111756	20563504	69791249	561	56088											
KIF22	3835	broad.mit.edu	37	chr16	29816249	29816249	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaatactggatctgctgaacGaaggctcagcccgagatctc	12	8	10	11	2	3	2	1	1	2	1	4	5	3	3	1	2	4	2	1	2	4	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:29816249G>A	uc002dts.3	+	12	1816	c.1792G>A	c.(1792-1794)GAA>AAA	p.E598K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KIF22_uc010vdv.1_Missense_Mutation_p.E530K|KIF22_uc010vdw.1_Missense_Mutation_p.E530K|KIF22_uc010bzf.2_Missense_Mutation_p.E544K|KIF22_uc002dtt.1_3'UTR|KIF22_uc002frc.1_RNA|MAZ_uc002dtv.1_5'Flank|MAZ_uc010vdx.1_5'Flank|MAZ_uc002dtw.2_5'Flank|MAZ_uc002dtx.2_5'Flank|MAZ_uc002dty.2_5'Flank|MAZ_uc010bzg.2_5'Flank|MAZ_uc002dtz.1_5'Flank	NM_007317	NP_015556	Q14807	KIF22_HUMAN	kinesin family member 22	598					blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding				0						TCTGCTGAACGAAGGCTCAGC	0.612													9	19					0	0	0	0	A	29816249	A	A	29816249	3	1	303	1	0	0	0	0	1	0	0	0	8329	1059	37	1	1838	1	KIF22	16	29816249	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	9252745	29816249	60538504	562	56089											
HIRIP3	8479	broad.mit.edu	37	chr16	30005976	30005976	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cttccccttgtaccccttttCctcctcctcactgctctcct	2	16	2	21	0	2	0	1	0	1	0	7	0	6	0	8	0	2	2	8	0	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:30005976C>T	uc002dve.2	-	4	951	c.490G>A	c.(490-492)GAA>AAA	p.E164K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvg.1_5'Flank|INO80E_uc002dvh.1_5'Flank|INO80E_uc002dvi.1_5'Flank|INO80E_uc002dvj.1_5'Flank|INO80E_uc002dvk.1_5'Flank|HIRIP3_uc002dvf.2_Intron	NM_003609	NP_003600	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	164	Glu-rich.				chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)	1						TACCCCTTTTCCTCCTCCTCA	0.567													77	114					0	0	0	0	T	30005976	T	T	30005976	3	4	303	1	0	0	0	0	1	0	0	0	7160	864	30	2	1196	2	HIRIP3	16	30005976	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	189727	30005976	60348777	563	56090											
VPS35	55737	broad.mit.edu	37	chr16	46696241	46696241	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gccctgatcaggtttctttaGaagtttggatgcagcaaggg	9	12	13	7	0	2	2	1	1	1	1	2	3	2	3	1	3	2	4	1	3	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:46696241G>C	uc002eef.3	-	15	2080	c.1981C>G	c.(1981-1983)CTA>GTA	p.L661V	VPS35_uc002eed.2_Missense_Mutation_p.L482V|VPS35_uc002eee.2_Missense_Mutation_p.L622V	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	661					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GGTTTCTTTAGAAGTTTGGAT	0.488													5	20					0	0	0	0	C	46696241	C	C	46696241	3	2	303	1	0	0	0	0	1	0	0	0	17271	933	33	2	421	2	VPS35	16	46696241	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	16690265	46696241	43658512	564	56091											
N4BP1	9683	broad.mit.edu	37	chr16	48596194	48596194	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acagcctcagcacttcctctGatgccaagaaggccaatgtc	11	8	8	14	0	2	2	1	1	1	1	4	2	3	2	4	1	3	1	4	1	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:48596194G>A	uc002efp.2	-	2	597	c.360C>T	c.(358-360)ATC>ATT	p.I120I		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	120					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				CACTTCCTCTGATGCCAAGAA	0.443													4	15					0	0	0	0	A	48596194	A	A	48596194	2	1	303	1	0	0	0	0	0	0	0	1	10162	1280	45	2		2	N4BP1	16	48596194	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1899953	48596194	41758559	565	56092											
RBL2	5934	broad.mit.edu	37	chr16	53513068	53513068	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actcttattgtttgccaggtCacaaaagaagataagtcctt	13	13	7	8	0	2	2	1	0	1	2	3	2	3	2	2	1	1	1	2	1	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:53513068C>T	uc002ehi.3	+	18	2824	c.2706C>T	c.(2704-2706)GTC>GTT	p.V902V	RBL2_uc002ehj.2_Silent_p.V612V|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	902	Domain B.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						TTTGCCAGGTCACAAAAGAAG	0.338													15	38					0	0	0	0	T	53513068	T	T	53513068	2	4	303	1	0	0	0	0	0	0	0	1	13175	813	29	2		2	RBL2	16	53513068	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4916874	53513068	36841685	566	56093											
CES7	221223	broad.mit.edu	37	chr16	55897354	55897354	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggaataagcctttggccatgGgagacagtatctggagagag	12	8	15	6	0	1	2	0	0	1	2	1	6	1	4	2	4	1	1	2	4	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:55897354G>A	uc002eip.2	-	6	865	c.716C>T	c.(715-717)CCC>CTC	p.P239L	CES7_uc002eio.2_Missense_Mutation_p.P239L|CES7_uc002eiq.2_5'UTR|CES7_uc002eir.2_Missense_Mutation_p.P133L	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	239						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		TTTGGCCATGGGAGACAGTAT	0.502													10	29					0	0	0	0	A	55897354	A	A	55897354	3	1	303	1	0	0	0	0	1	0	0	0	3287	1232	43	4	1043	4	CES7	16	55897354	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2384286	55897354	34457399	567	56094											
NLRC5	84166	broad.mit.edu	37	chr16	57081464	57081464	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tgcccctttgcagcctcagtGagtgtcctctggagccccca	5	10	10	16	0	2	1	1	1	1	0	3	2	3	2	6	1	4	1	6	1	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:57081464G>A	uc002ekk.1	+	23	3571	c.3346G>A	c.(3346-3348)GAG>AAG	p.E1116K	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.E835K|NLRC5_uc002ekl.2_Missense_Mutation_p.E921K|NLRC5_uc002ekm.2_Missense_Mutation_p.E891K|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekp.1_Missense_Mutation_p.E32K|NLRC5_uc002ekq.1_5'UTR|NLRC5_uc002ekr.1_Missense_Mutation_p.E32K	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1116					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CAGCCTCAGTGAGTGTCCTCT	0.627													6	15					0	0	0	0	A	57081464	A	A	57081464	3	1	303	1	0	0	0	0	1	0	0	0	10524	1291	45	2	3428	2	NLRC5	16	57081464	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1184110	57081464	33273289	568	56095											
ZNF319	57567	broad.mit.edu	37	chr16	58032106	58032106	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggtggctctgcatggtgctGaggctgcggtggctgtggct	2	11	19	9	2	1	1	0	1	1	0	1	1	1	1	0	7	3	6	0	7	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:58032106G>A	uc002emx.1	-	2	687	c.64C>T	c.(64-66)CAG>TAG	p.Q22*		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	22	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCATGGTGCTGAGGCTGCGGT	0.647													17	66					0	0	0	0	A	58032106	A	A	58032106	4	1	303	1	0	0	0	0	0	1	0	0	17904	1299	45	2	1688	2	ZNF319	16	58032106	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	950642	58032106	32322647	569	56096											
GOT2	2806	broad.mit.edu	37	chr16	58742194	58742194	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gaactccttgatcagccgctCcacctgcagagaggaaagaa	13	6	10	12	1	1	3	1	1	0	2	3	6	3	4	4	1	3	2	4	1	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:58742194C>G	uc002eof.1	-	10	1288	c.1174G>C	c.(1174-1176)GAG>CAG	p.E392Q	GOT2_uc010vim.1_Missense_Mutation_p.E349Q	NM_002080	NP_002071	P00505	AATM_HUMAN	aspartate aminotransferase 2 precursor	392					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ATCAGCCGCTCCACCTGCAGA	0.557													11	34					0	0	0	0	G	58742194	G	G	58742194	3	3	303	1	0	0	0	0	1	0	0	0	6618	864	30	2	122	2	GOT2	16	58742194	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	710088	58742194	31612559	570	56097											
ELMO3	79767	broad.mit.edu	37	chr16	67237258	67237258	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gccgacatgagggcactcctGacaggcaaggactgccccca	10	4	12	15	1	0	2	0	2	0	0	1	4	1	3	4	3	1	2	4	3	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:67237258G>A	uc002esa.2	+	18	2011	c.1968G>A	c.(1966-1968)CTG>CTA	p.L656L	ELMO3_uc002esb.2_Silent_p.L639L|ELMO3_uc002esc.2_Silent_p.L490L|uc010vjf.1_5'Flank|MIR328_hsa-mir-328|MI0000804_5'Flank	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	603	PH.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		GGGCACTCCTGACAGGCAAGG	0.692													5	12					0	0	0	0	A	67237258	A	A	67237258	2	1	303	1	0	0	0	0	0	0	0	1	5091	1277	45	2		2	ELMO3	16	67237258	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	8495064	67237258	23117495	571	56098											
KCTD19	146212	broad.mit.edu	37	chr16	67338376	67338376	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gagggtttgctaatacacttCcatgtacgccagtagttcag	10	12	10	9	1	1	0	1	0	0	0	2	1	2	0	2	1	3	5	2	1	4	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:67338376C>G	uc002esu.2	-	3	450	c.399G>C	c.(397-399)TGG>TGC	p.W133C	KCTD19_uc002est.2_5'UTR|KCTD19_uc010vjj.1_5'UTR	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	133						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TAATACACTTCCATGTACGCC	0.488													25	62					0	0	0	0	G	67338376	G	G	67338376	3	3	303	1	0	0	0	0	1	0	0	0	8145	856	30	2	2437	2	KCTD19	16	67338376	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	101118	67338376	23016377	572	56099											
CTCF	10664	broad.mit.edu	37	chr16	67670652	67670652	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagcctgccgtagaaattGaacctgagccagagcctcag	12	6	12	11	1	1	4	1	2	0	2	1	5	1	5	5	1	5	1	5	1	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:67670652G>A	uc002etl.2	+	11	2187	c.1897G>A	c.(1897-1899)GAA>AAA	p.E633K	CTCF_uc010cek.2_Missense_Mutation_p.E305K|CTCF_uc002etm.1_Missense_Mutation_p.E122K	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	633					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		CGTAGAAATTGAACCTGAGCC	0.567													47	98					0	0	0	0	A	67670652	A	A	67670652	3	1	303	1	0	0	0	0	1	0	0	0	4017	1291	45	2	1931	2	CTCF	16	67670652	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	332276	67670652	22684101	573	56100											
CTCF	10664	broad.mit.edu	37	chr16	67671611	67671611	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacagctatcattcaggttGaagaccagaatacaggtgca	15	8	9	9	0	2	3	2	1	0	2	2	3	2	3	1	2	4	3	1	2	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:67671611G>C	uc002etl.2	+	12	2310	c.2020G>C	c.(2020-2022)GAA>CAA	p.E674Q	CTCF_uc010cek.2_Missense_Mutation_p.E346Q|CTCF_uc002etm.1_Missense_Mutation_p.E161Q	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	674					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		CATTCAGGTTGAAGACCAGAA	0.468													9	32					0	0	0	0	C	67671611	C	C	67671611	3	2	303	1	0	0	0	0	1	0	0	0	4017	1291	45	2	2058	2	CTCF	16	67671611	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	959	67671611	22683142	574	56101											
EDC4	23644	broad.mit.edu	37	chr16	67915424	67915424	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gcagccatgggatcccggctCacagagcaccaggtaagtga	11	5	13	12	1	1	2	1	1	0	1	2	3	2	3	3	3	2	4	3	3	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:67915424C>T	uc002eur.2	+	21	2980	c.2814C>T	c.(2812-2814)CTC>CTT	p.L938L	EDC4_uc010cer.2_Silent_p.L557L|EDC4_uc002eus.2_Silent_p.L668L|EDC4_uc002eut.1_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	938					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		GATCCCGGCTCACAGAGCACC	0.592													14	47					0	0	0	0	T	67915424	T	T	67915424	2	4	303	1	0	0	0	0	0	0	0	1	4930	813	29	2		2	EDC4	16	67915424	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	243813	67915424	22439329	575	56102											
CIRH1A	84916	broad.mit.edu	37	chr16	69170620	69170620	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttttcccaggtcatgagtctCgggctacagaagctttgtgc	7	13	11	10	1	2	2	1	1	1	1	4	2	3	2	1	2	3	2	1	2	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:69170620C>T	uc002ews.3	+	3	277	c.181C>T	c.(181-183)CGG>TGG	p.R61W	CIRH1A_uc002ewr.2_Missense_Mutation_p.R61W|CIRH1A_uc002ewt.3_5'UTR|CIRH1A_uc010cfi.2_5'UTR	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	61	WD 2.					nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		TCATGAGTCTCGGGCTACAGA	0.463													34	105					0	0	0	0	T	69170620	T	T	69170620	3	4	303	1	0	0	0	0	1	0	0	0	3449	875	31	1	187	1	CIRH1A	16	69170620	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1255196	69170620	21184133	576	56103											
MLYCD	23417	broad.mit.edu	37	chr16	83948560	83948560	+	Splice_Site	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caccccaaccatgctttacaGagagagtttcctcaccttgg	10	10	7	14	0	1	2	1	0	0	2	2	3	2	2	5	1	3	2	5	1	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:83948560G>C	uc002fgz.2	+	5	969	c.949_splice	c.e5-1	p.R317_splice		NM_012213	NP_036345	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase precursor						acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity				0						ATGCTTTACAGAGAGAGTTTC	0.493													17	44					0	0	0	0	C	83948560	C	C	83948560	5	2	303	1	0	0	0	0	0	0	1	0	9691	956	33	2	966	2	MLYCD	16	83948560	Splice_Site	SNP	G	TCGA-HL-7533-01A-11D-2229-08	14777940	83948560	6406193	577	56104											
TCF25	22980	broad.mit.edu	37	chr16	89977645	89977645	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gggggagggggagtgggactGagcgtccgcagaggtgaccg	7	4	23	7	3	0	3	0	2	0	1	1	6	1	6	2	6	1	1	2	6	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr16:89977645G>C	uc002fpb.2	+	18	2112	c.2030G>C	c.(2029-2031)TGA>TCA	p.*677S	TCF25_uc002fpc.2_3'UTR|uc010ciy.1_5'Flank	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	677					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		GAGTGGGACTGAGCGTCCGCA	0.607													15	48					0	0	0	0	C	89977645	C	C	89977645	4	2	303	1	0	0	0	0	0	0	0	0	15759	1285	45	2	2100	2	TCF25	16	89977645	Nonstop_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	6029085	89977645	377108	578	56105											
RNMTL1	55178	broad.mit.edu	37	chr17	686377	686377	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cgggaaaaacaagggaagatCctgctggaaggtcgcaggct	13	5	15	8	2	0	1	0	0	0	1	2	4	1	4	1	5	2	3	1	5	5	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:686377C>G	uc002frw.2	+	2	475	c.369C>G	c.(367-369)ATC>ATG	p.I123M	GLOD4_uc002fru.2_5'Flank|GLOD4_uc010vqc.1_5'Flank|GLOD4_uc002frv.2_5'Flank	NM_018146	NP_060616	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	123					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		AAGGGAAGATCCTGCTGGAAG	0.428													9	33					0	0	0	0	G	686377	G	G	686377	3	3	303	1	0	0	0	0	1	0	0	0	13572	845	30	2	375	2	RNMTL1	17	686377	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08		686377	80508833	579	56106											
NXN	64359	broad.mit.edu	37	chr17	708312	708312	+	Frame_Shift_Del	DEL	A	-	-																															cccgtgagcttcatacctacAaaaaggacgaggcaggggcc																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:708312delA	uc002fsa.2	-	6	1088	c.996delT	c.(994-996)TTTfs	p.F332fs	NXN_uc010vqd.1_Intron|NXN_uc002frz.2_Frame_Shift_Del_p.F83fs|NXN_uc010vqe.1_Frame_Shift_Del_p.F224fs	NM_022463	NP_071908	Q6DKJ4	NXN_HUMAN	nucleoredoxin	332					cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			ovary(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		TCATACCTACAAAAAGGACGA	0.682													---	---	---								-	708312	-	-	708312	7	5	303	1	0	1	0	1	0	0	0	0	10841	127	5	0	323	0	NXN	17	708312	Frame_Shift_Del	DEL	A	TCGA-HL-7533-01A-11D-2229-08	21935	708312	80486898	580	56107											
SLC43A2	124935	broad.mit.edu	37	chr17	1478937	1478937	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ttggacgagccgttgattttGaggaagagtttgtcatcctc	8	14	12	7	2	1	3	1	2	0	1	3	6	2	5	2	2	1	2	2	2	1	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:1478937G>C	uc002fsv.2	-	14	1760	c.1671C>G	c.(1669-1671)CTC>CTG	p.L557L	SLC43A2_uc002fsu.2_Silent_p.L561L	NM_152346	NP_689559	Q8N370	LAT4_HUMAN	solute carrier family 43, member 2	557					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		CGTTGATTTTGAGGAAGAGTT	0.622													8	26					0	0	0	0	C	1478937	C	C	1478937	2	2	303	1	0	0	0	0	0	0	0	1	14697	1277	45	2		2	SLC43A2	17	1478937	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	770625	1478937	79716273	581	56108											
OR1A1	8383	broad.mit.edu	37	chr17	3119395	3119395	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccaatgccctcccccacactCtgctcacagctagtctgtcc	7	9	5	20	0	3	0	1	0	2	0	5	0	5	0	5	0	3	2	5	0	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:3119395C>T	uc010vrc.1	+	1	481	c.481C>T	c.(481-483)CTG>TTG	p.L161L		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCCCCACACTCTGCTCACAGC	0.502													19	49					0	0	0	0	T	3119395	T	T	3119395	2	4	303	1	0	0	0	0	0	0	0	1	11003	912	32	2		2	OR1A1	17	3119395	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1640458	3119395	78075815	582	56109											
ACADVL	37	broad.mit.edu	37	chr17	7123805	7123805	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggctctggacaagtcagattCccacccctctgacgctctga	8	9	9	15	1	4	3	1	2	3	1	5	4	5	4	3	2	0	2	3	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:7123805C>T	uc002gev.2	+	3	312	c.161C>T	c.(160-162)TCC>TTC	p.S54F	DLG4_uc010cly.2_5'Flank|DLG4_uc002get.3_5'Flank|DLG4_uc010vto.1_5'Flank|DLG4_uc002geu.2_5'Flank|ACADVL_uc010vtp.1_Missense_Mutation_p.S64F|ACADVL_uc010vtq.1_Missense_Mutation_p.S100F|ACADVL_uc002gew.2_Intron|ACADVL_uc002gex.2_5'UTR	NM_000018	NP_000009	P49748	ACADV_HUMAN	acyl-Coenzyme A dehydrogenase, very long chain	54	Catalytic.				energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			ovary(3)	3						AAGTCAGATTCCCACCCCTCT	0.597													15	37					0	0	0	0	T	7123805	T	T	7123805	3	4	303	1	0	0	0	0	1	0	0	0	116	855	30	2	171	2	ACADVL	17	7123805	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4004410	7123805	74071405	583	56110											
GABARAP	11337	broad.mit.edu	37	chr17	7144691	7144691	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgacccattgtggcactggtGggtggaatgacattgttgac	8	12	14	7	0	0	3	0	3	0	0	0	4	0	4	1	4	0	2	1	4	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:7144691G>A	uc002gfb.2	-	3	362	c.258C>T	c.(256-258)CCC>CCT	p.P86P	PHF23_uc002gfa.2_5'Flank|PHF23_uc010vtt.1_5'Flank|PHF23_uc010cma.2_5'Flank	NM_007278	NP_009209	O95166	GBRAP_HUMAN	GABA(A) receptor-associated protein	86	Interaction with GPHN (By similarity).				protein targeting|synaptic transmission	autophagic vacuole membrane|Golgi membrane|microtubule|plasma membrane	beta-tubulin binding|GABA receptor binding				0						TGGCACTGGTGGGTGGAATGA	0.483													109	275					0	0	0	0	A	7144691	A	A	7144691	2	1	303	1	0	0	0	0	0	0	0	1	6186	1335	47	4		4	GABARAP	17	7144691	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	20886	7144691	74050519	584	56111											
NEURL4	84461	broad.mit.edu	37	chr17	7222436	7222436	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccgtttgagggcacaggcaGaagcagggaagttgagcctc	10	6	15	10	1	0	3	0	2	0	1	1	4	0	4	2	3	2	5	2	3	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:7222436G>A	uc002gga.1	-	22	3624	c.3617C>T	c.(3616-3618)TCT>TTT	p.S1206F	NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_5'UTR|NEURL4_uc002ggb.1_Missense_Mutation_p.S1204F	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	1206	NHR 6.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GGCACAGGCAGAAGCAGGGAA	0.597													11	40					0	0	0	0	A	7222436	A	A	7222436	3	1	303	1	0	0	0	0	1	0	0	0	10401	942	33	2	1103	2	NEURL4	17	7222436	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	77745	7222436	73972774	585	56112											
POLR2A	5430	broad.mit.edu	37	chr17	7417451	7417451	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagccccacctacagtctCacaagcccggctatcagccc	10	5	6	20	1	2	0	2	0	1	0	3	0	2	0	6	1	4	1	6	1	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:7417451C>T	uc002ghf.3	+	29	6102	c.5868C>T	c.(5866-5868)CTC>CTT	p.L1956L		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1956	52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].|52; approximate.				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				CCTACAGTCTCACAAGCCCGG	0.527													15	57					0	0	0	0	T	7417451	T	T	7417451	2	4	303	1	0	0	0	0	0	0	0	1	12269	813	29	2		2	POLR2A	17	7417451	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	195015	7417451	73777759	586	56113											
PFAS	5198	broad.mit.edu	37	chr17	8158400	8158400	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtcagtgtgccgcgccactGggctggggcctgtggatcgt	3	10	17	11	3	1	0	1	0	0	0	2	1	1	1	3	4	1	1	3	4	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:8158400G>C	uc002gkr.2	+	4	475	c.334G>C	c.(334-336)GGG>CGG	p.G112R	PFAS_uc010vuv.1_5'UTR	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	112					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCGCGCCACTGGGCTGGGGCC	0.602													23	96					0	0	0	0	C	8158400	C	C	8158400	3	2	303	1	0	0	0	0	1	0	0	0	11809	1348	47	4	344	4	PFAS	17	8158400	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	740949	8158400	73036810	587	56114											
RANGRF	29098	broad.mit.edu	37	chr17	8192666	8192666	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtttggagaacctggccctGaggggccgctgtcaagaagc	9	7	15	10	1	1	3	1	1	0	2	1	4	1	3	3	4	2	2	3	4	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:8192666G>C	uc002gkv.2	+	3	403	c.285G>C	c.(283-285)CTG>CTC	p.L95L	SLC25A35_uc002gku.1_3'UTR|SLC25A35_uc002gkt.2_Intron|RANGRF_uc002gkw.2_Silent_p.L95L|RANGRF_uc002gky.2_Silent_p.L95L|RANGRF_uc002gkx.2_Silent_p.L95L|SLC25A35_uc002gkz.1_RNA	NM_016492	NP_057576	Q9HD47	MOG1_HUMAN	RAN guanine nucleotide release factor	95				ALR -> PE (in Ref. 3; AAF36156).	protein transport	cytoplasm|nucleus	guanyl-nucleotide exchange factor activity				0						ACCTGGCCCTGAGGGGCCGCT	0.582													14	30					0	0	0	0	C	8192666	C	C	8192666	2	2	303	1	0	0	0	0	0	0	0	1	13099	1277	45	2		2	RANGRF	17	8192666	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	34266	8192666	73002544	588	56115											
PIK3R5	23533	broad.mit.edu	37	chr17	8784012	8784012	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagagaagggagcagagatCaggtgcggcctgggccggca	10	3	19	9	2	1	2	1	0	0	2	1	5	1	3	2	5	2	3	2	5	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:8784012C>A	uc002glt.2	-	19	2654	c.2587G>T	c.(2587-2589)GAT>TAT	p.D863Y	PIK3R5_uc010vuz.1_Missense_Mutation_p.D863Y|PIK3R5_uc002glu.3_Missense_Mutation_p.D477Y	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	863					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GAGCAGAGATCAGGTGCGGCC	0.632													7	18					0.00198382	0.00199518	1	0	A	8784012	A	A	8784012	3	1	303	1	0	0	0	0	1	0	0	0	11977	826	29	2	59	2	PIK3R5	17	8784012	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	591346	8784012	72411198	589	56116											
MYH2	4620	broad.mit.edu	37	chr17	10439886	10439886	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtctggaaagaagagcccttCttcttaccacctttcttggc	8	13	8	12	0	4	2	0	0	4	2	4	3	4	3	3	2	2	0	3	2	3	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:10439886C>G	uc010coi.2	-	17	2063	c.1935G>C	c.(1933-1935)AAG>AAC	p.K645N	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.K645N|MYH2_uc010coj.2_Missense_Mutation_p.K645N	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	645	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AAGAGCCCTTCTTCTTACCAC	0.393													5	15					0	0	0	0	G	10439886	G	G	10439886	3	3	303	1	0	0	0	0	1	0	0	0	10088	912	32	2	3986	2	MYH2	17	10439886	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1655874	10439886	70755324	590	56117											
C17orf48	56985	broad.mit.edu	37	chr17	10608643	10608643	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acactaagtttctagaagatCagattgtacatcatcctgag	14	12	7	8	0	3	4	2	1	1	3	4	4	4	4	1	0	1	2	1	0	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:10608643C>G	uc002gmt.2	+	2	475	c.400C>G	c.(400-402)CAG>GAG	p.Q134E	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA|C17orf48_uc010vvg.1_Missense_Mutation_p.Q134E	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	134							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						TCTAGAAGATCAGATTGTACA	0.338													23	33					0	0	0	0	G	10608643	G	G	10608643	3	3	303	1	0	0	0	0	1	0	0	0	1866	827	29	2	402	2	C17orf48	17	10608643	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	168757	10608643	70586567	591	56118											
DNAH9	1770	broad.mit.edu	37	chr17	11593142	11593142	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	acgtggaagccatggagttgGagtgcaaacagtttgcccgg	10	8	15	8	2	0	0	0	0	0	0	0	3	0	3	2	4	4	3	2	4	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:11593142G>A	uc002gne.2	+	20	4071	c.4003G>A	c.(4003-4005)GAG>AAG	p.E1335K	DNAH9_uc010coo.2_Missense_Mutation_p.E629K	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1335	Potential.|Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CATGGAGTTGGAGTGCAAACA	0.562													3	9					0	0	0	0	A	11593142	A	A	11593142	3	1	303	1	0	0	0	0	1	0	0	0	4630	1175	41	2	4081	2	DNAH9	17	11593142	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	984499	11593142	69602068	592	56119											
ZNF287	57336	broad.mit.edu	37	chr17	16455379	16455379	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agtatgagttctctgatgttGattaagtgatgaggaataaa	14	14	11	2	0	1	5	0	5	1	0	2	6	1	6	0	1	0	3	0	1	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:16455379G>A	uc002gqi.2	-	6	2530	c.2077C>T	c.(2077-2079)CAA>TAA	p.Q693*		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	686	C2H2-type 12.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		CTCTGATGTTGATTAAGTGAT	0.363													12	37					0	0	0	0	A	16455379	A	A	16455379	4	1	303	1	0	0	0	0	0	1	0	0	17892	1299	45	2	212	2	ZNF287	17	16455379	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4862237	16455379	64739831	593	56120											
FAM83G	644815	broad.mit.edu	37	chr17	18907111	18907111	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctgagaggggcccgtgccccGagggtcctcagagcccgggt	5	5	17	14	3	1	2	1	1	0	2	2	4	2	2	5	4	2	0	5	4	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:18907111G>A	uc002guw.2	-	2	411	c.244C>T	c.(244-246)CGG>TGG	p.R82W	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	82										ovary(1)|central_nervous_system(1)	2						CCCGTGCCCCGAGGGTCCTCA	0.697													6	8					0	0	0	0	A	18907111	A	A	18907111	3	1	303	1	0	0	0	0	1	0	0	0	5671	1057	37	1	2247	1	FAM83G	17	18907111	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2451732	18907111	62288099	594	56121											
ATAD5	79915	broad.mit.edu	37	chr17	29162420	29162420	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatatgaagtaggaagagatGataattctaaaaaaatcatg	20	11	8	2	0	2	3	1	2	1	1	2	5	2	4	0	1	0	1	0	1	10	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:29162420G>A	uc002hfs.1	+	2	1667	c.1321G>A	c.(1321-1323)GAT>AAT	p.D441N	ATAD5_uc002hft.1_Missense_Mutation_p.D338N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	441					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGGAAGAGATGATAATTCTAA	0.323													6	20					0	0	0	0	A	29162420	A	A	29162420	3	1	303	1	0	0	0	0	1	0	0	0	1078	1290	45	2	1327	2	ATAD5	17	29162420	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10255309	29162420	52032790	595	56122											
C17orf42	79736	broad.mit.edu	37	chr17	29226355	29226355	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tccgccttcagtatagaatcGaagagaaactgcttcactag	13	10	8	10	2	2	2	2	0	0	2	4	4	3	2	2	0	2	2	2	0	6	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:29226355G>A	uc002hfu.2	-	4	985	c.915C>T	c.(913-915)TTC>TTT	p.F305F	C17orf42_uc002hfv.2_RNA	NM_024683	NP_078959	Q96QE5	TEFM_HUMAN	hypothetical protein LOC79736	305					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding			ovary(1)	1		all_cancers(10;4.64e-07)|all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				GTATAGAATCGAAGAGAAACT	0.428													11	34					0	0	0	0	A	29226355	A	A	29226355	2	1	303	1	0	0	0	0	0	0	0	1	1863	1049	37	1		1	C17orf42	17	29226355	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	63935	29226355	51968855	596	56123											
NF1	4763	broad.mit.edu	37	chr17	29559770	29559770	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	actgcagtgaagttgaagatGaaagtgcgcaaacaggtggc	14	7	14	6	1	0	4	0	3	0	1	0	4	0	4	0	2	3	3	0	2	4	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:29559770G>A	uc002hgg.2	+	26	3700	c.3367G>A	c.(3367-3369)GAA>AAA	p.E1123K	NF1_uc002hgh.2_Missense_Mutation_p.E1123K|NF1_uc010csn.1_Missense_Mutation_p.E983K|NF1_uc002hgi.1_Missense_Mutation_p.E156K	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1123					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGTTGAAGATGAAAGTGCGCA	0.433			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			21	37					0	0	0	0	A	29559770	A	A	29559770	3	1	303	1	0	0	0	0	1	0	0	0	10410	1291	45	2	3530	2	NF1	17	29559770	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	333415	29559770	51635440	597	56124											
TMEM98	26022	broad.mit.edu	37	chr17	31267910	31267910	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accagtctctgtcggctgctGaggagcatttggaagtcctt	7	12	12	10	1	1	1	0	1	1	0	4	3	2	3	2	3	2	3	2	3	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:31267910G>A	uc002hhq.2	+	8	1038	c.580G>A	c.(580-582)GAG>AAG	p.E194K	TMEM98_uc002hhr.2_Missense_Mutation_p.E194K	NM_015544	NP_056359	Q9Y2Y6	TMM98_HUMAN	transmembrane protein 98	194						endoplasmic reticulum|integral to membrane					0		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)			GTCGGCTGCTGAGGAGCATTT	0.572													16	43					0	0	0	0	A	31267910	A	A	31267910	3	1	303	1	0	0	0	0	1	0	0	0	16291	1291	45	2	602	2	TMEM98	17	31267910	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1708140	31267910	49927300	598	56125											
LIG3	3980	broad.mit.edu	37	chr17	33318806	33318806	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttccttctgcggctgtccaaGctcaccaaggaggatgagca	9	9	11	12	1	2	1	1	1	1	0	4	3	4	3	3	3	3	3	3	3	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:33318806G>A	uc002hik.1	+	6	1266	c.1158G>A	c.(1156-1158)AAG>AAA	p.K386K	LIG3_uc002hij.2_Silent_p.K386K|LIG3_uc010cth.1_Silent_p.K395K	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	386					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	GGCTGTCCAAGCTCACCAAGG	0.552								Other_BER_factors					14	29					0	0	0	0	A	33318806	A	A	33318806	2	1	303	1	0	0	0	0	0	0	0	1	8823	962	34	4		4	LIG3	17	33318806	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2050896	33318806	47876404	599	56126											
AP2B1	163	broad.mit.edu	37	chr17	34050652	34050652	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcctaacagctgtcactGaagtgtagagctcctgaagt	10	12	9	10	0	2	3	1	2	1	1	4	3	3	3	2	0	3	3	2	0	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:34050652G>A	uc002hjr.2	+	21	2937	c.2748G>A	c.(2746-2748)CTG>CTA	p.L916L	AP2B1_uc002hjq.2_Silent_p.L930L|AP2B1_uc010wci.1_Silent_p.L892L|AP2B1_uc002hjs.2_Silent_p.L859L|AP2B1_uc002hjt.2_Silent_p.L930L|AP2B1_uc010ctv.2_Silent_p.L930L|AP2B1_uc010wcj.1_Silent_p.L667L	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	916	Interaction with ARRB1.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AGCTGTCACTGAAGTGTAGAG	0.423													17	31					0	0	0	0	A	34050652	A	A	34050652	2	1	303	1	0	0	0	0	0	0	0	1	741	1277	45	2		2	AP2B1	17	34050652	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	731846	34050652	47144558	600	56127											
SRCIN1	80725	broad.mit.edu	37	chr17	36705380	36705380	+	Frame_Shift_Del	DEL	C	-	-																															gggaggaggggaagctccggCggggagggggcggtgggggc																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:36705380delC	uc002hqd.2	-	16	3254	c.3029delG	c.(3028-3030)CGCfs	p.R1010fs	SRCIN1_uc002hqf.1_Frame_Shift_Del_p.R882fs|SRCIN1_uc002hqe.2_Frame_Shift_Del_p.R864fs	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	882	Pro-rich.				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						GAAGCTCCGGCGGGGAGGGGG	0.662													---	---	---								-	36705380	-	-	36705380	7	5	303	1	0	1	0	1	0	0	0	0	15202	768	27	0	538	0	SRCIN1	17	36705380	Frame_Shift_Del	DEL	C	TCGA-HL-7533-01A-11D-2229-08	2654728	36705380	44489830	601	56128											
CACNB1	782	broad.mit.edu	37	chr17	37343170	37343170	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagccgcccgatccaccagtCattattgtatttctgcaaag	10	11	7	13	2	2	0	1	0	1	0	3	1	3	0	4	0	2	2	4	0	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:37343170C>T	uc002hrm.1	-	5	580	c.427G>A	c.(427-429)GAC>AAC	p.D143N	CACNB1_uc002hrl.1_5'UTR|CACNB1_uc002hrn.2_Missense_Mutation_p.D143N|CACNB1_uc002hro.2_Missense_Mutation_p.D143N|CACNB1_uc002hrp.1_Missense_Mutation_p.D143N|CACNB1_uc010web.1_Missense_Mutation_p.D96N	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	143	SH3.				axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	ATCCACCAGTCATTATTGTAT	0.552													21	38					0	0	0	0	T	37343170	T	T	37343170	3	4	303	1	0	0	0	0	1	0	0	0	2564	826	29	2	1673	2	CACNB1	17	37343170	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	637790	37343170	43852040	602	56129											
THRA	7067	broad.mit.edu	37	chr17	38240145	38240145	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccacctattcctgcaaatatGacagctgctgtgtcattgac	10	12	7	12	0	1	2	1	2	0	0	2	2	2	2	3	0	3	3	3	0	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:38240145G>A	uc002htw.2	+	5	763	c.280G>A	c.(280-282)GAC>AAC	p.D94N	THRA_uc010cwp.1_Missense_Mutation_p.D94N|THRA_uc002htv.2_Missense_Mutation_p.D94N|THRA_uc002htx.2_Missense_Mutation_p.D94N	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	94	NR C4-type.|Nuclear receptor.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	CTGCAAATATGACAGCTGCTG	0.562													26	53					0	0	0	0	A	38240145	A	A	38240145	3	1	303	1	0	0	0	0	1	0	0	0	15939	1290	45	2	294	2	THRA	17	38240145	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	896975	38240145	42955065	603	56130											
UBTF	7343	broad.mit.edu	37	chr17	42287534	42287534	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctgccttcttaatccacatCagtttctccttcttttccat	6	18	3	14	0	4	0	1	0	3	0	7	0	6	0	4	0	1	2	4	0	1	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:42287534C>T	uc002igb.2	-	14	1651	c.1584G>A	c.(1582-1584)CTG>CTA	p.L528L	UBTF_uc002igc.2_Silent_p.L491L|UBTF_uc010czs.2_Silent_p.L528L|UBTF_uc002igd.2_Silent_p.L491L|UBTF_uc010czt.2_Silent_p.L528L|UBTF_uc002ige.2_Silent_p.L491L	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	528	HMG box 5.				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		TAATCCACATCAGTTTCTCCT	0.493											OREG0024456	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	101					0	0	0	0	T	42287534	T	T	42287534	2	4	303	1	0	0	0	0	0	0	0	1	16977	813	29	2		2	UBTF	17	42287534	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4047389	42287534	38907676	604	56131											
GPATCH8	23131	broad.mit.edu	37	chr17	42477256	42477256	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cagggggttctggtttgggtCctcgttcagaatctgctggg	4	13	16	8	1	3	1	1	0	2	1	5	1	4	1	1	5	1	4	1	5	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:42477256C>G	uc002igw.1	-	8	2253	c.2189G>C	c.(2188-2190)GGA>GCA	p.G730A	GPATCH8_uc002igv.1_Missense_Mutation_p.G652A|GPATCH8_uc010wiz.1_Missense_Mutation_p.G652A	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	730						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TGGTTTGGGTCCTCGTTCAGA	0.532													17	41					0	0	0	0	G	42477256	G	G	42477256	3	3	303	1	0	0	0	0	1	0	0	0	6632	855	30	2	2323	2	GPATCH8	17	42477256	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	189722	42477256	38717954	605	56132											
PLEKHM1	9842	broad.mit.edu	37	chr17	43531395	43531395	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	1	0	0	0	0	cctcagcttcgtcctgggagGaggcgcgcagggccagcttc	5	7	15	14	3	1	0	1	0	0	0	4	2	2	2	3	4	2	3	3	4	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:43531395G>C	uc002ija.2	-	7	1993	c.1823C>G	c.(1822-1824)TCC>TGC	p.S608C	PLEKHM1_uc010wjm.1_Missense_Mutation_p.S580C|PLEKHM1_uc002ijb.2_Missense_Mutation_p.S83C|PLEKHM1_uc010wjn.1_Missense_Mutation_p.S557C|PLEKHM1_uc002ijc.2_Missense_Mutation_p.S62C	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	608	PH 1.				intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					GTCCTGGGAGGAGGCGCGCAG	0.642													13	50					0	0	0	0	C	43531395	C	C	43531395	3	2	303	1	0	0	0	0	1	0	0	0	12135	1174	41	2	1371	2	PLEKHM1	17	43531395	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1054139	43531395	37663815	606	56133											
KIAA1267	284058	broad.mit.edu	37	chr17	44116447	44116447	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattttgctgtggtttgggtCatgcacgggtggtggtgggt	3	15	18	5	1	1	0	1	0	0	0	1	0	1	0	0	6	2	3	0	6	0	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:44116447C>T	uc002ikb.2	-	8	2423	c.2338G>A	c.(2338-2340)GAC>AAC	p.D780N	KIAA1267_uc002ikc.2_Missense_Mutation_p.D780N|KIAA1267_uc002ikd.2_Missense_Mutation_p.D780N|KIAA1267_uc010dav.2_Missense_Mutation_p.D780N|KIAA1267_uc010wkb.1_Missense_Mutation_p.D111N|KIAA1267_uc010wkc.1_Intron	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	780						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				TGGTTTGGGTCATGCACGGGT	0.582													32	72					0	0	0	0	T	44116447	T	T	44116447	3	4	303	1	0	0	0	0	1	0	0	0	8258	826	29	2	1007	2	KIAA1267	17	44116447	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	585052	44116447	37078763	607	56134											
ITGA3	3675	broad.mit.edu	37	chr17	48154040	48154040	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcagagcagcagcagaagctGagcaggtggctgtgggccgc	9	5	17	10	1	1	3	1	1	0	2	1	3	1	3	1	3	5	6	1	3	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:48154040G>A	uc010dbl.2	+	14	2381	c.1917G>A	c.(1915-1917)CTG>CTA	p.L639L	ITGA3_uc010dbm.2_Silent_p.L639L	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	639	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						AGCAGAAGCTGAGCAGGTGGC	0.657													17	43					0	0	0	0	A	48154040	A	A	48154040	2	1	303	1	0	0	0	0	0	0	0	1	7916	1277	45	2		2	ITGA3	17	48154040	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4037593	48154040	33041170	608	56135											
MBTD1	54799	broad.mit.edu	37	chr17	49272689	49272689	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gtctgctgcttctgagccatCgatcccaatcatcaggaatc	9	11	8	13	1	4	1	2	1	2	0	7	3	5	2	2	1	3	2	2	1	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:49272689C>T	uc002itr.3	-	13	1602	c.1258G>A	c.(1258-1260)GAT>AAT	p.D420N	MBTD1_uc002itp.3_Missense_Mutation_p.D256N|MBTD1_uc002itq.3_Intron	NM_017643	NP_060113	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	420	MBT 3.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			TCTGAGCCATCGATCCCAATC	0.388													19	42					0	0	0	0	T	49272689	T	T	49272689	3	4	303	1	0	0	0	0	1	0	0	0	9413	884	31	1	648	1	MBTD1	17	49272689	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1118649	49272689	31922521	609	56136											
BZRAP1	9256	broad.mit.edu	37	chr17	56386091	56386091	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tagcaggagctggtgatgctGatgcccccgctgcccgcctc	5	8	13	15	2	0	2	0	2	0	0	1	3	0	3	4	2	5	4	4	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:56386091G>C	uc002ivx.3	-	22	5413	c.4542C>G	c.(4540-4542)ATC>ATG	p.I1514M	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Missense_Mutation_p.I1454M|BZRAP1_uc010wnt.1_Missense_Mutation_p.I1514M	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1514						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGGTGATGCTGATGCCCCCGC	0.632													12	20					0	0	0	0	C	56386091	C	C	56386091	3	2	303	1	0	0	0	0	1	0	0	0	1582	1280	45	2	1071	2	BZRAP1	17	56386091	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7113402	56386091	24809119	610	56137											
PRR11	55771	broad.mit.edu	37	chr17	57270939	57270939	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatgtgcctgcctgcgttctGatcacccctggagactccaa	8	10	9	14	1	2	2	1	1	1	1	3	3	3	2	5	1	3	1	5	1	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:57270939G>C	uc002ixf.1	+	5	568	c.489G>C	c.(487-489)CTG>CTC	p.L163L	PRR11_uc002ixg.1_RNA	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	proline rich 11	163										ovary(2)	2	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CCTGCGTTCTGATCACCCCTG	0.408													15	52					0	0	0	0	C	57270939	C	C	57270939	2	2	303	1	0	0	0	0	0	0	0	1	12645	1277	45	2		2	PRR11	17	57270939	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	884848	57270939	23924271	611	56138											
RPS6KB1	6198	broad.mit.edu	37	chr17	58013615	58013615	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttctcgtctgggagctggtCctggggacgctggagaagtt	5	11	16	9	2	2	1	0	0	2	1	4	4	3	3	1	5	1	3	1	5	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:58013615C>G	uc002ixy.2	+	11	1121	c.1018C>G	c.(1018-1020)CCT>GCT	p.P340A	RPS6KB1_uc010ddj.1_Missense_Mutation_p.P340A|RPS6KB1_uc010wom.1_Missense_Mutation_p.P287A|RPS6KB1_uc010won.1_Missense_Mutation_p.P317A|RPS6KB1_uc010woo.1_Missense_Mutation_p.P275A	NM_003161	NP_003152	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide	340	Protein kinase.				apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			large_intestine(1)	1	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			GGGAGCTGGTCCTGGGGACGC	0.398													16	50					0	0	0	0	G	58013615	G	G	58013615	3	3	303	1	0	0	0	0	1	0	0	0	13721	855	30	2	1060	2	RPS6KB1	17	58013615	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	742676	58013615	23181595	612	56139											
C17orf64	124773	broad.mit.edu	37	chr17	58504131	58504131	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agctggaagcaaagcagcttCgccgactttacaagtacacc	13	7	9	12	2	0	0	0	0	0	0	1	2	0	1	2	1	6	5	2	1	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:58504131C>T	uc002iyq.2	+	4	471	c.382C>T	c.(382-384)CGC>TGC	p.R128C		NM_181707	NP_859058	Q86WR6	CQ064_HUMAN	hypothetical protein LOC124773	128										breast(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;5.81e-13)|all cancers(12;2.17e-11)|Colorectal(3;0.01)			AAAGCAGCTTCGCCGACTTTA	0.602													4	13					0	0	0	0	T	58504131	T	T	58504131	3	4	303	1	0	0	0	0	1	0	0	0	1879	884	31	1	396	1	C17orf64	17	58504131	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	490516	58504131	22691079	613	56140											
APPBP2	10513	broad.mit.edu	37	chr17	58577812	58577812	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aacttccaattcacaaaattCactgcccagttgacataagc	15	10	4	12	0	2	1	2	1	0	0	3	1	3	1	2	0	3	1	2	0	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:58577812C>T	uc002iys.1	-	2	463	c.175G>A	c.(175-177)GAA>AAA	p.E59K	APPBP2_uc010ddl.1_Intron	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	59	TPR 1.				intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			TCACAAAATTCACTGCCCAGT	0.234													10	21					0	0	0	0	T	58577812	T	T	58577812	3	4	303	1	0	0	0	0	1	0	0	0	816	835	29	2	1630	2	APPBP2	17	58577812	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	73681	58577812	22617398	614	56141											
INTS2	57508	broad.mit.edu	37	chr17	59989349	59989349	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaaggattcattttacacaaGaagcgtaaggcatctgtcct	13	11	9	8	1	2	1	1	0	1	1	3	3	3	2	1	2	2	2	1	2	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:59989349G>C	uc002izn.2	-	6	832	c.756C>G	c.(754-756)TTC>TTG	p.F252L	INTS2_uc002izm.2_Missense_Mutation_p.F244L	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	252					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						TTTTACACAAGAAGCGTAAGG	0.433													23	73					0	0	0	0	C	59989349	C	C	59989349	3	2	303	1	0	0	0	0	1	0	0	0	7817	933	33	2	2938	2	INTS2	17	59989349	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1411537	59989349	21205861	615	56142											
TLK2	11011	broad.mit.edu	37	chr17	60683575	60683575	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtgtggtcggtgggtgtgatCttctatcagtgtctttatgg	4	17	15	5	1	4	1	1	1	3	0	5	1	4	1	0	4	0	0	0	4	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:60683575C>G	uc010ddp.2	+	21	2278	c.2010C>G	c.(2008-2010)ATC>ATG	p.I670M	TLK2_uc002izx.3_Missense_Mutation_p.I496M|TLK2_uc002izz.3_Missense_Mutation_p.I648M|TLK2_uc002jaa.3_Missense_Mutation_p.I616M|TLK2_uc010wpd.1_Missense_Mutation_p.I616M	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	670	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						TGGGTGTGATCTTCTATCAGT	0.433													10	27					0	0	0	0	G	60683575	G	G	60683575	3	3	303	1	0	0	0	0	1	0	0	0	16010	903	32	2	2018	2	TLK2	17	60683575	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	694226	60683575	20511635	616	56143											
MAP3K3	4215	broad.mit.edu	37	chr17	61762899	61762899	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gctggatcccctgagcagtgCagaaaattccttgtctggaa	10	10	11	10	0	1	2	0	1	1	1	3	4	3	4	3	2	2	3	3	2	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:61762899C>T	uc002jbg.2	+	8	978	c.659C>T	c.(658-660)GCA>GTA	p.A220V	MAP3K3_uc002jbe.2_Missense_Mutation_p.A251V|MAP3K3_uc002jbf.2_Missense_Mutation_p.A251V|MAP3K3_uc002jbh.2_Missense_Mutation_p.A251V|MAP3K3_uc010wpo.1_Missense_Mutation_p.A135V|MAP3K3_uc010wpp.1_Missense_Mutation_p.A220V	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	220					MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6						CTGAGCAGTGCAGAAAATTCC	0.532													16	41					0	0	0	0	T	61762899	T	T	61762899	3	4	303	1	0	0	0	0	1	0	0	0	9304	710	25	4	786	4	MAP3K3	17	61762899	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1079324	61762899	19432311	617	56144											
FTSJ3	117246	broad.mit.edu	37	chr17	61902704	61902704	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aaagatccatagcagaggctGatagtcacgagaacggaaaa	18	5	11	7	2	1	4	1	1	0	3	2	6	2	5	1	2	2	2	1	2	6	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:61902704G>A	uc002jbz.2	-	6	571	c.493C>T	c.(493-495)CAG>TAG	p.Q165*	FTSJ3_uc002jca.2_Nonsense_Mutation_p.Q165*|PSMC5_uc002jcb.2_5'Flank|PSMC5_uc010ddy.2_5'Flank|PSMC5_uc010ddz.2_5'Flank|PSMC5_uc002jcc.2_5'Flank|PSMC5_uc002jcd.2_5'Flank	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	165					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						AGCAGAGGCTGATAGTCACGA	0.527													20	37					0	0	0	0	A	61902704	A	A	61902704	4	1	303	1	0	0	0	0	0	1	0	0	6123	1299	45	2	2110	2	FTSJ3	17	61902704	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	139805	61902704	19292506	618	56145											
SCN4A	6329	broad.mit.edu	37	chr17	62025372	62025372	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gaagaccttgtcggcatattCtaggatggtgcgaatgactc	10	11	12	8	2	1	2	0	1	1	1	3	5	1	3	1	3	1	1	1	3	4	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:62025372C>G	uc002jds.1	-	17	3273	c.3196G>C	c.(3196-3198)GAA>CAA	p.E1066Q		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1066	III.|Helical; Name=S2 of repeat III; (Potential).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TCGGCATATTCTAGGATGGTG	0.572													10	27					0	0	0	0	G	62025372	G	G	62025372	3	3	303	1	0	0	0	0	1	0	0	0	13985	922	32	2	2346	2	SCN4A	17	62025372	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	122668	62025372	19169838	619	56146											
HELZ	9931	broad.mit.edu	37	chr17	65105258	65105258	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cctcccctataggtaatcccGaggggttctcatcaatgaag	10	10	9	12	1	2	1	2	1	1	0	5	2	4	1	4	3	0	2	4	3	5	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:65105258G>A	uc010wqk.1	-	29	4653	c.4466C>T	c.(4465-4467)TCG>TTG	p.S1489L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.S1488L|HELZ_uc010der.2_Missense_Mutation_p.S32L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGGTAATCCCGAGGGGTTCTC	0.448													14	31					0	0	0	0	A	65105258	A	A	65105258	3	1	303	1	0	0	0	0	1	0	0	0	7088	1059	37	1	1385	1	HELZ	17	65105258	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3079886	65105258	16089952	620	56147											
ABCA10	10349	broad.mit.edu	37	chr17	67181702	67181702	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atacatactgggtgaaaactCccaacaatgagtttcacgag	15	9	8	9	1	1	2	1	2	0	0	2	3	2	2	1	1	4	1	1	1	6	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:67181702C>T	uc010dfa.1	-	21	3292	c.2413G>A	c.(2413-2415)GAG>AAG	p.E805K	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.E406K	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	805					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GGTGAAAACTCCCAACAATGA	0.373													19	40					0	0	0	0	T	67181702	T	T	67181702	3	4	303	1	0	0	0	0	1	0	0	0	29	864	30	2	2298	2	ABCA10	17	67181702	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2076444	67181702	14013508	621	56148											
NAT9	26151	broad.mit.edu	37	chr17	72768370	72768370	+	Silent	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ttcttaccgtaagacagcatCgcgagaacggcctcagtgcc	10	8	10	13	4	2	2	1	0	1	2	3	3	2	2	3	1	4	2	3	1	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:72768370C>G	uc002jlq.2	-	5	455	c.381G>C	c.(379-381)GCG>GCC	p.A127A	NAT9_uc002jlr.2_Silent_p.A126A	NM_015654	NP_056469	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9	127	N-acetyltransferase.					protein complex	N-acetyltransferase activity				0						AAGACAGCATCGCGAGAACGG	0.493													9	33					0	0	0	0	G	72768370	G	G	72768370	2	3	303	1	0	0	0	0	0	0	0	1	10235	871	31	3		3	NAT9	17	72768370	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5586668	72768370	8426840	622	56149											
ATP5H	10476	broad.mit.edu	37	chr17	73038632	73038632	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaacatactgacctggaggtGagggtctcattccaggattt	11	11	11	8	0	1	2	1	2	1	0	3	4	2	4	2	4	2	0	2	4	2	3	rs139761287		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:73038632G>C	uc002jmn.1	-	2	178	c.114C>G	c.(112-114)CTC>CTG	p.L38L	KCTD2_uc010dfy.1_Intron|KCTD2_uc010dfz.2_Intron|ATP5H_uc002jmo.1_Silent_p.L38L	NM_006356	NP_006347	O75947	ATP5H_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	38					ATP catabolic process|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity				0	all_lung(278;0.226)					ACCTGGAGGTGAGGGTCTCAT	0.428													43	140					0	0	0	0	C	73038632	C	C	73038632	2	2	303	1	0	0	0	0	0	0	0	1	1158	1277	45	2		2	ATP5H	17	73038632	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	270262	73038632	8156578	623	56150											
MGAT5B	146664	broad.mit.edu	37	chr17	74902123	74902123	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctggtccacatcggcttcctGacggaggagtccggggacgt	6	8	15	12	4	0	1	0	1	0	0	4	4	3	4	3	6	0	1	3	6	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:74902123G>C	uc002jti.2	+	7	1015	c.912G>C	c.(910-912)CTG>CTC	p.L304L	MGAT5B_uc002jth.2_Silent_p.L293L	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	293	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						TCGGCTTCCTGACGGAGGAGT	0.677													19	62					0	0	0	0	C	74902123	C	C	74902123	2	2	303	1	0	0	0	0	0	0	0	1	9602	1277	45	2		2	MGAT5B	17	74902123	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1863491	74902123	6293087	624	56151											
TBC1D16	125058	broad.mit.edu	37	chr17	77915904	77915904	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atgtgcatggccaggtttccGaagtgcaggagcatctggtc	8	10	14	9	1	1	0	0	0	1	0	3	2	2	1	2	4	3	4	2	4	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:77915904G>T	uc002jxj.2	-	11	2126	c.2010C>A	c.(2008-2010)TTC>TTA	p.F670L	TBC1D16_uc002jxh.2_Missense_Mutation_p.F308L|TBC1D16_uc002jxi.2_Missense_Mutation_p.F295L	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	670						intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			CCAGGTTTCCGAAGTGCAGGA	0.647													9	39					1.61879e-10	1.66624e-10	1	0	T	77915904	T	T	77915904	3	4	303	1	0	0	0	0	1	0	0	0	15671	1049	37	3	301	3	TBC1D16	17	77915904	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3013781	77915904	3279306	625	56152											
RNF213	57674	broad.mit.edu	37	chr17	78357725	78357725	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcctctggcatttcctgcaGaaggtatgtctggcttactg	7	14	10	10	0	2	1	0	0	2	1	4	1	4	1	2	3	2	4	2	3	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:78357725G>A	uc002jyh.1	+	34	8761	c.8538G>A	c.(8536-8538)CAG>CAA	p.Q2846Q	uc002jyi.1_Intron|RNF213_uc010dhx.1_5'Flank	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATTTCCTGCAGAAGGTATGTC	0.483													17	70					0	0	0	0	A	78357725	A	A	78357725	2	1	303	1	0	0	0	0	0	0	0	1	13542	933	33	2		2	RNF213	17	78357725	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	441821	78357725	2837485	626	56153											
FLJ35220	284131	broad.mit.edu	37	chr17	78403629	78403629	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aggagactccggagagtcctCaggtgagggccagcccccac	9	4	14	14	1	1	3	1	1	0	2	3	5	3	3	5	4	1	0	5	4	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:78403629C>T	uc002jym.1	+	9	864	c.836C>T	c.(835-837)TCA>TTA	p.S279L	FLJ35220_uc002jyk.2_Missense_Mutation_p.S234L|FLJ35220_uc002jyl.1_Missense_Mutation_p.S234L|FLJ35220_uc002jyn.2_Missense_Mutation_p.S85L	NM_173627	NP_775898	Q8N8Q3	ENDOV_HUMAN	hypothetical protein LOC284131 isoform 1	279					DNA repair		endodeoxyribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			GGAGAGTCCTCAGGTGAGGGC	0.657								Direct_reversal_of_damage|Editing_and_processing_nucleases					14	38					0	0	0	0	T	78403629	T	T	78403629	3	4	303	1	0	0	0	0	1	0	0	0	5959	838	29	2	870	2	FLJ35220	17	78403629	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	45904	78403629	2791581	627	56154											
CCDC137	339230	broad.mit.edu	37	chr17	79637270	79637270	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcagcccaggtgaccttcaGaaagacattggagaaggaag	14	6	12	9	0	2	4	2	1	0	3	2	6	2	5	2	3	1	0	2	3	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:79637270G>A	uc002kbc.3	+	3	320	c.284G>A	c.(283-285)AGA>AAA	p.R95K	CCDC137_uc002kbd.2_RNA	NM_199287	NP_954981	Q6PK04	CC137_HUMAN	coiled-coil domain containing 137	95										central_nervous_system(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GTGACCTTCAGAAAGACATTG	0.587													6	19					0	0	0	0	A	79637270	A	A	79637270	3	1	303	1	0	0	0	0	1	0	0	0	2783	942	33	2	294	2	CCDC137	17	79637270	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1233641	79637270	1557940	628	56155											
CCDC137	339230	broad.mit.edu	37	chr17	79637313	79637313	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagggagaggagcccgacatCgcagtccccaagttcaaaca	14	4	11	12	2	1	1	1	0	0	1	3	4	2	2	3	2	2	2	3	2	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:79637313C>T	uc002kbc.3	+	3	363	c.327C>T	c.(325-327)ATC>ATT	p.I109I	CCDC137_uc002kbd.2_RNA	NM_199287	NP_954981	Q6PK04	CC137_HUMAN	coiled-coil domain containing 137	109										central_nervous_system(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			AGCCCGACATCGCAGTCCCCA	0.577													10	22					0	0	0	0	T	79637313	T	T	79637313	2	4	303	1	0	0	0	0	0	0	0	1	2783	874	31	1		1	CCDC137	17	79637313	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	43	79637313	1557897	629	56156											
GPS1	2873	broad.mit.edu	37	chr17	80014847	80014847	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctccgcaaccagatccatgtCaaggtgggctggcttgaggg	8	8	14	11	1	1	2	1	1	0	1	3	2	3	2	3	4	1	3	3	4	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:80014847C>T	uc002kdl.1	+	12	1443	c.1398C>T	c.(1396-1398)GTC>GTT	p.V466V	GPS1_uc002kdk.1_Silent_p.V502V|GPS1_uc010dij.1_Silent_p.V501V|GPS1_uc002kdm.1_Silent_p.V446V|GPS1_uc002kdn.1_Silent_p.V462V|GPS1_uc002kdo.1_Silent_p.V465V|GPS1_uc010wvh.1_Silent_p.V458V	NM_004127	NP_004118	Q13098	CSN1_HUMAN	G protein pathway suppressor 1 isoform 2	466					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			AGATCCATGTCAAGGTGGGCT	0.652													16	48					0	0	0	0	T	80014847	T	T	80014847	2	4	303	1	0	0	0	0	0	0	0	1	6771	813	29	2		2	GPS1	17	80014847	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	377534	80014847	1180363	630	56157											
CCDC57	284001	broad.mit.edu	37	chr17	80129712	80129712	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tagagttcgtatttctgcttCaagggccagaacataatctg	11	13	9	8	1	3	2	1	0	2	2	4	2	3	2	1	1	2	3	1	1	5	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:80129712C>T	uc002kdz.1	-	13	2102	c.1747G>A	c.(1747-1749)GAA>AAA	p.E583K	CCDC57_uc002kdx.1_Missense_Mutation_p.E583K|CCDC57_uc010dik.1_Missense_Mutation_p.E91K	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	583	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			ATTTCTGCTTCAAGGGCCAGA	0.443													16	58					0	0	0	0	T	80129712	T	T	80129712	3	4	303	1	0	0	0	0	1	0	0	0	2840	835	29	2	1024	2	CCDC57	17	80129712	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	114865	80129712	1065498	631	56158											
ZNF750	79755	broad.mit.edu	37	chr17	80790115	80790116	+	Frame_Shift_Ins	INS	-	TC	TC																															gctggttggtttgcttggggINStctagtgagttagatttagg																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:80790115_80790116insTC	uc002kga.2	-	2	526_527	c.215_216insGA	c.(214-216)GACfs	p.D72fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	72						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TTTGCTTGGGGTCTAGTGAGTT	0.475													---	---	---								TC	80790116	TC	TC	80790115	7	5	303	1	0	1	1	0	0	0	0	0	18199	1252	44	0	1963	0	ZNF750	17	80790115	Frame_Shift_Ins	INS	-	TCGA-HL-7533-01A-11D-2229-08	660403	80790115	405095	632	56159											
ZNF750	79755	broad.mit.edu	37	chr17	80790149	80790149	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atttagggcacttgggaactCgatcctgctctgatactaaa	11	12	9	9	1	1	1	0	1	1	0	3	3	2	2	1	2	3	2	1	2	5	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr17:80790149C>T	uc002kga.2	-	2	493	c.182G>A	c.(181-183)CGA>CAA	p.R61Q	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	61						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CTTGGGAACTCGATCCTGCTC	0.448													11	41					0	0	0	0	T	80790149	T	T	80790149	3	4	303	1	0	0	0	0	1	0	0	0	18199	884	31	1	1997	1	ZNF750	17	80790149	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	34	80790149	405061	633	56160											
COLEC12	81035	broad.mit.edu	37	chr18	357515	357515	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ttggtacattgtgttccttcCtgaatacctgtaagagaagt	10	15	9	7	0	0	2	0	1	0	1	2	3	2	2	3	1	2	3	3	1	5	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:357515C>T	uc002kkm.2	-	3	281	c.66G>A	c.(64-66)CAG>CAA	p.Q22Q		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	22	Cytoplasmic (Potential).			Q -> H (in Ref. 1; BAB39148).	carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GTGTTCCTTCCTGAATACCTG	0.303													11	28					0	0	0	0	T	357515	T	T	357515	2	4	303	1	0	0	0	0	0	0	0	1	3727	680	24	4		4	COLEC12	18	357515	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08		357515	77719733	634	56161											
TYMS	7298	broad.mit.edu	37	chr18	662243	662243	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagcctgggattctccaccaGagaagaaggggacttgggcc	10	6	14	11	0	1	2	0	0	1	2	2	5	1	4	4	4	1	0	4	4	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:662243G>C	uc010dka.1	+	3	516	c.377G>C	c.(376-378)AGA>ACA	p.R126T	TYMS_uc010dkb.1_Missense_Mutation_p.R126T|TYMS_uc010dkc.1_Intron	NM_001071	NP_001062	P04818	TYSY_HUMAN	thymidylate synthase	126					DNA repair|DNA replication|phosphatidylinositol-mediated signaling|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to organophosphorus	cytosol	thymidylate synthase activity				0					Capecitabine(DB01101)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Gemcitabine(DB00441)|Leucovorin(DB00650)|Pemetrexed(DB00642)|Raltitrexed(DB00293)|Trifluridine(DB00432)	TTCTCCACCAGAGAAGAAGGG	0.493													78	218					0	0	0	0	C	662243	C	C	662243	3	2	303	1	0	0	0	0	1	0	0	0	16880	942	33	2	387	2	TYMS	18	662243	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	304728	662243	77415005	635	56162											
LAMA1	284217	broad.mit.edu	37	chr18	6943353	6943353	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagtggcggttttgggctCatatgcagctgttatcctgc	6	13	12	10	1	1	0	1	0	0	0	2	0	2	0	1	3	3	5	1	3	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:6943353C>T	uc002knm.2	-	62	8987	c.8893G>A	c.(8893-8895)GAG>AAG	p.E2965K	LAMA1_uc002knk.2_Missense_Mutation_p.E295K|LAMA1_uc002knl.2_Missense_Mutation_p.E418K|LAMA1_uc010wzj.1_Missense_Mutation_p.E2441K	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2965	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTTTTGGGCTCATATGCAGCT	0.438													34	86					0	0	0	0	T	6943353	T	T	6943353	3	4	303	1	0	0	0	0	1	0	0	0	8645	835	29	2	342	2	LAMA1	18	6943353	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6281110	6943353	71133895	636	56163											
LAMA1	284217	broad.mit.edu	37	chr18	6975007	6975007	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acaggaaggccactctccctCgccgcatctccactgcaagg	9	6	9	17	2	2	0	0	0	2	0	5	1	2	1	4	3	1	2	4	3	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:6975007C>T	uc002knm.2	-	46	6612	c.6518G>A	c.(6517-6519)CGA>CAA	p.R2173Q	LAMA1_uc010wzj.1_Missense_Mutation_p.R1649Q	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2173	Laminin G-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACTCTCCCTCGCCGCATCTC	0.542													7	12					0	0	0	0	T	6975007	T	T	6975007	3	4	303	1	0	0	0	0	1	0	0	0	8645	884	31	1	2781	1	LAMA1	18	6975007	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	31654	6975007	71102241	637	56164											
LAMA1	284217	broad.mit.edu	37	chr18	6978282	6978282	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ggcagatgtgttcagcagctCctggctcagccccgccacgt	6	8	12	15	2	2	1	2	0	0	1	3	1	3	1	4	2	3	5	4	2	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:6978282C>T	uc002knm.2	-	43	6197	c.6103G>A	c.(6103-6105)GAG>AAG	p.E2035K	LAMA1_uc010wzj.1_Missense_Mutation_p.E1511K	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2035	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCAGCAGCTCCTGGCTCAGC	0.587													22	48					0	0	0	0	T	6978282	T	T	6978282	3	4	303	1	0	0	0	0	1	0	0	0	8645	864	30	2	3208	2	LAMA1	18	6978282	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3275	6978282	71098966	638	56165											
LAMA1	284217	broad.mit.edu	37	chr18	6978307	6978307	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctcagccccgccacgtccctCagcgtgctcaccgcgctctg	4	7	9	21	5	4	0	3	0	1	0	5	0	5	0	5	0	3	2	5	0	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:6978307C>T	uc002knm.2	-	43	6172	c.6078G>A	c.(6076-6078)CTG>CTA	p.L2026L	LAMA1_uc010wzj.1_Silent_p.L1502L	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2026	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCACGTCCCTCAGCGTGCTCA	0.537													19	41					0	0	0	0	T	6978307	T	T	6978307	2	4	303	1	0	0	0	0	0	0	0	1	8645	813	29	2		2	LAMA1	18	6978307	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	25	6978307	71098941	639	56166											
LAMA1	284217	broad.mit.edu	37	chr18	6992681	6992681	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attgggtagtaggaaatcttCatccaaagtctgatttaaag	14	13	9	5	0	3	1	1	1	2	0	4	2	4	2	1	2	0	2	1	2	6	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:6992681C>T	uc002knm.2	-	36	5141	c.5047G>A	c.(5047-5049)GAA>AAA	p.E1683K	LAMA1_uc010wzj.1_Missense_Mutation_p.E1159K	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1683	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGAAATCTTCATCCAAAGTC	0.353													13	40					0	0	0	0	T	6992681	T	T	6992681	3	4	303	1	0	0	0	0	1	0	0	0	8645	835	29	2	4292	2	LAMA1	18	6992681	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	14374	6992681	71084567	640	56167											
RALBP1	10928	broad.mit.edu	37	chr18	9535686	9535686	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagataaagaacaatcatttGaatcaagcaattcatgagga	20	9	7	5	0	3	4	3	2	0	2	3	5	3	5	0	1	2	1	0	1	8	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:9535686G>C	uc002kob.2	+	10	1942	c.1719G>C	c.(1717-1719)TTG>TTC	p.L573F	RALBP1_uc002koc.2_Missense_Mutation_p.L573F	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	573					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1						ACAATCATTTGAATCAAGCAA	0.552													6	17					0	0	0	0	C	9535686	C	C	9535686	3	2	303	1	0	0	0	0	1	0	0	0	13077	1281	45	2	1753	2	RALBP1	18	9535686	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2543005	9535686	68541562	641	56168											
IMPA2	3613	broad.mit.edu	37	chr18	12028068	12028068	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaaggccttggttctgacaGaaattggccccaaacgtgac	12	8	10	11	1	1	3	0	2	1	1	1	3	1	3	3	3	1	1	3	3	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:12028068G>T	uc002kqp.1	+	6	731	c.517G>T	c.(517-519)GAA>TAA	p.E173*	IMPA2_uc002kqo.1_5'UTR|IMPA2_uc002kqq.1_Nonsense_Mutation_p.E53*	NM_014214	NP_055029	O14732	IMPA2_HUMAN	inositol(myo)-1(or 4)-monophosphatase 2	173					inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(2)	2					Lithium(DB01356)	GGTTCTGACAGAAATTGGCCC	0.498													17	61					4.63292e-17	4.83101e-17	1	0	T	12028068	T	T	12028068	4	4	303	1	0	0	0	0	0	1	0	0	7762	943	33	2	539	2	IMPA2	18	12028068	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2492382	12028068	66049180	642	56169											
OSBPL1A	114876	broad.mit.edu	37	chr18	21805078	21805078	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cttcggacattctgtgttttCtactgcccaaatgctctcct	6	16	6	13	1	3	0	0	0	3	0	5	1	3	1	2	1	3	2	2	1	2	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:21805078C>G	uc002kve.2	-	17	1703	c.1529G>C	c.(1528-1530)AGA>ACA	p.R510T	OSBPL1A_uc002kvd.2_5'UTR|OSBPL1A_uc010xbc.1_Missense_Mutation_p.R128T|OSBPL1A_uc002kvf.3_Missense_Mutation_p.R290T	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	510					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					TCTGTGTTTTCTACTGCCCAA	0.507													28	55					0	0	0	0	G	21805078	G	G	21805078	3	3	303	1	0	0	0	0	1	0	0	0	11331	913	32	2	1371	2	OSBPL1A	18	21805078	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	9777010	21805078	56272170	643	56170											
DSG1	1828	broad.mit.edu	37	chr18	28909991	28909991	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggacaaatagaagaaaattCtaatgcaagtaagtaatgta	21	9	8	3	0	1	2	0	0	1	2	1	3	1	3	0	1	1	4	0	1	10	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:28909991C>G	uc002kwp.2	+	5	721	c.509C>G	c.(508-510)TCT>TGT	p.S170C		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	170	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GAAGAAAATTCTAATGCAAGT	0.398													17	30					0	0	0	0	G	28909991	G	G	28909991	3	3	303	1	0	0	0	0	1	0	0	0	4798	913	32	2	527	2	DSG1	18	28909991	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	7104913	28909991	49167257	644	56171											
ACAA2	10449	broad.mit.edu	37	chr18	47322138	47322138	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atttttatggttccaaccttGatatctgatccaagcttggt	9	17	7	8	0	1	2	0	2	1	0	3	2	3	2	3	2	2	2	3	2	4	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:47322138G>C	uc002ldw.3	-	4	823	c.426C>G	c.(424-426)ATC>ATG	p.I142M	ACAA2_uc002ldx.3_Missense_Mutation_p.I139M	NM_006111	NP_006102	P42765	THIM_HUMAN	acetyl-coenzyme A acyltransferase 2	142					anti-apoptosis|cholesterol biosynthetic process		acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1						TTCCAACCTTGATATCTGATC	0.338													7	20					0	0	0	0	C	47322138	C	C	47322138	3	2	303	1	0	0	0	0	1	0	0	0	105	1280	45	2	795	2	ACAA2	18	47322138	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	18412147	47322138	30755110	645	56172											
ZNF532	55205	broad.mit.edu	37	chr18	56648829	56648829	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaccaatgaggaggaaacaGaaataaaagaagacactaag	22	3	9	7	0	0	4	0	1	0	3	0	6	0	6	2	2	1	0	2	2	7	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:56648829G>C	uc002lho.2	+	10	3938	c.3391G>C	c.(3391-3393)GAA>CAA	p.E1131Q	ZNF532_uc002lhp.2_Missense_Mutation_p.E1129Q|ZNF532_uc010xeg.1_Missense_Mutation_p.E1129Q|ZNF532_uc002lhr.2_Missense_Mutation_p.E1129Q|ZNF532_uc002lhs.2_Missense_Mutation_p.E1129Q|ZNF532_uc010xeh.1_Missense_Mutation_p.E219Q	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GGAGGAAACAGAAATAAAAGA	0.403													9	17					0	0	0	0	C	56648829	C	C	56648829	3	2	303	1	0	0	0	0	1	0	0	0	18039	943	33	2	3417	2	ZNF532	18	56648829	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	9326691	56648829	21428419	646	56173											
CCBE1	147372	broad.mit.edu	37	chr18	57363930	57363930	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tcgtcgcgattttgctctctGagcagatttctctatgaaaa	9	15	8	9	3	2	3	0	2	2	1	6	4	2	3	0	0	2	2	0	0	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:57363930G>A	uc002lib.2	-	2	213	c.143C>T	c.(142-144)TCA>TTA	p.S48L		NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	48					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				TTTGCTCTCTGAGCAGATTTC	0.582											OREG0025022	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	40					0	0	0	0	A	57363930	A	A	57363930	3	1	303	1	0	0	0	0	1	0	0	0	2743	1294	45	2	1117	2	CCBE1	18	57363930	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	715101	57363930	20713318	647	56174											
TSHZ1	10194	broad.mit.edu	37	chr18	72999979	72999979	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgctgatggcagcagctttGaggaggcgttggacgagctg	8	9	17	7	2	0	2	0	2	0	0	0	5	0	4	0	4	4	6	0	4	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr18:72999979G>C	uc002lly.2	+	2	3045	c.2482G>C	c.(2482-2484)GAG>CAG	p.E828Q		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	873						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CAGCAGCTTTGAGGAGGCGTT	0.607													8	22					0	0	0	0	C	72999979	C	C	72999979	3	2	303	1	0	0	0	0	1	0	0	0	16690	1291	45	2	2484	2	TSHZ1	18	72999979	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	15636049	72999979	5077269	648	56175											
APBA3	9546	broad.mit.edu	37	chr19	3759866	3759866	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caacagtcggggggcaggctCtagaggctcttcaggaccag	9	6	15	11	1	3	1	1	0	2	1	4	2	3	2	1	6	1	3	1	6	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:3759866C>G	uc002lyp.1	-	2	574	c.397G>C	c.(397-399)GAG>CAG	p.E133Q	MRPL54_uc002lyq.3_5'Flank	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	133					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGCAGGCTCTAGAGGCTCT	0.657													20	41					0	0	0	0	G	3759866	G	G	3759866	3	3	303	1	0	0	0	0	1	0	0	0	758	922	32	2	1370	2	APBA3	19	3759866	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08		3759866	55369117	649	56176											
MPND	84954	broad.mit.edu	37	chr19	4345870	4345870	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgaaccctgccaagaagtcGggctgtggctgggcctctgt	6	9	15	11	1	1	2	0	1	1	1	2	2	1	2	3	3	2	2	3	3	3	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:4345870G>A	uc002mae.2	+	3	490	c.423G>A	c.(421-423)TCG>TCA	p.S141S	MPND_uc010dtx.2_RNA|MPND_uc002mag.2_Silent_p.S141S|MPND_uc002maf.2_Silent_p.S141S|MPND_uc002mah.2_Silent_p.S29S|MPND_uc002mai.2_Silent_p.S29S	NM_032868	NP_116257	Q8N594	MPND_HUMAN	MPN domain containing isoform 1	141							peptidase activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAAGAAGTCGGGCTGTGGCT	0.622													17	59					0	0	0	0	A	4345870	A	A	4345870	2	1	303	1	0	0	0	0	0	0	0	1	9784	1103	39	1		1	MPND	19	4345870	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	586004	4345870	54783113	650	56177											
LRG1	116844	broad.mit.edu	37	chr19	4538895	4538895	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tggggctcagggtgacccccCaggctgaggctgccaacagc	7	5	15	14	0	1	2	1	2	0	0	1	2	1	2	4	5	3	3	4	5	1	0	rs142669067		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:4538895C>G	uc002mau.2	-	2	112	c.101G>C	c.(100-102)TGG>TCG	p.W34S	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	34						extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGACCCCCCAGGCTGAGGC	0.582													20	69					0	0	0	0	G	4538895	G	G	4538895	3	3	303	1	0	0	0	0	1	0	0	0	8992	595	21	4	946	4	LRG1	19	4538895	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	193025	4538895	54590088	651	56178											
SAFB2	9667	broad.mit.edu	37	chr19	5595458	5595458	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgattttatcaaacgacaaGatgtctctcttttctttgct	9	19	5	8	1	4	2	1	1	3	1	5	3	4	2	0	0	2	1	0	0	3	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:5595458G>A	uc002mcd.2	-	14	2045	c.1833C>T	c.(1831-1833)ATC>ATT	p.I611I		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	611	Interacts with SAFB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		CAAACGACAAGATGTCTCTCT	0.478													6	10					0	0	0	0	A	5595458	A	A	5595458	2	1	303	1	0	0	0	0	0	0	0	1	13872	932	33	2		2	SAFB2	19	5595458	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1056563	5595458	53533525	652	56179											
TMEM146	257062	broad.mit.edu	37	chr19	5776273	5776273	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	acagcaaaccagatcattttCggccacaatggcttttatgt	12	12	7	10	1	1	1	1	0	0	1	2	1	1	1	2	2	2	2	2	2	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:5776273C>T	uc002mda.2	+	21	2104	c.2043C>T	c.(2041-2043)TTC>TTT	p.F681F		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	681	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGATCATTTTCGGCCACAATG	0.557													12	14					0	0	0	0	T	5776273	T	T	5776273	2	4	303	1	0	0	0	0	0	0	0	1	16126	883	31	1		1	TMEM146	19	5776273	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	180815	5776273	53352710	653	56180											
TUBB4	10382	broad.mit.edu	37	chr19	6501390	6501390	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccaggtccaccagcaccgctCtggggacataatttcctcct	8	9	8	16	1	1	0	0	0	1	0	4	1	4	1	6	3	1	2	6	3	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:6501390C>G	uc002mfg.1	-	3	292	c.185G>C	c.(184-186)AGA>ACA	p.R62T	TUBB4_uc002mff.1_5'UTR	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	62					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		CAGCACCGCTCTGGGGACATA	0.607													5	17					0	0	0	0	G	6501390	G	G	6501390	3	3	303	1	0	0	0	0	1	0	0	0	16826	913	32	2	1157	2	TUBB4	19	6501390	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	725117	6501390	52627593	654	56181											
SH2D3A	10045	broad.mit.edu	37	chr19	6754983	6754983	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gagggggcatcatgggggcaGaaagagatctcagcctgtgg	10	6	18	7	0	2	2	2	0	1	2	3	4	2	2	1	5	1	2	1	5	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:6754983G>T	uc002mft.2	-	5	1034	c.840C>A	c.(838-840)TTC>TTA	p.F280L	SH2D3A_uc010xjg.1_Missense_Mutation_p.F158L	NM_005490	NP_005481	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	280					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(2)	2						CATGGGGGCAGAAAGAGATCT	0.612													57	157					9.53615e-21	1.00033e-20	1	0	T	6754983	T	T	6754983	3	4	303	1	0	0	0	0	1	0	0	0	14298	933	33	2	914	2	SH2D3A	19	6754983	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	253593	6754983	52374000	655	56182											
ARHGEF18	23370	broad.mit.edu	37	chr19	7529459	7529459	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttctcagatggcagtttcaaGaagaaagtcagcagcactga	14	9	10	8	0	3	4	3	1	1	3	4	4	3	4	0	1	2	4	0	1	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:7529459G>A	uc002mgi.2	+	13	2476	c.2223G>A	c.(2221-2223)AAG>AAA	p.K741K	ARHGEF18_uc010xjm.1_Silent_p.K583K|ARHGEF18_uc002mgh.2_Silent_p.K583K|ARHGEF18_uc002mgj.1_Silent_p.K384K	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	741					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				GCAGTTTCAAGAAGAAAGTCA	0.632													10	51					0	0	0	0	A	7529459	A	A	7529459	2	1	303	1	0	0	0	0	0	0	0	1	901	933	33	2		2	ARHGEF18	19	7529459	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	774476	7529459	51599524	656	56183											
PNPLA6	10908	broad.mit.edu	37	chr19	7605588	7605588	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gccttctcagcatcctggatGtcatcaccgtgagtgaccag	8	10	10	13	1	3	2	3	2	1	0	5	3	4	3	4	1	1	1	4	1	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:7605588G>A	uc010xjq.1	+	8	1009	c.814G>A	c.(814-816)GTC>ATC	p.V272I	PNPLA6_uc002mgq.1_Missense_Mutation_p.V224I|PNPLA6_uc010xjp.1_Missense_Mutation_p.V224I|PNPLA6_uc002mgr.1_Missense_Mutation_p.V224I|PNPLA6_uc002mgs.2_Missense_Mutation_p.V263I	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	263	cNMP 1.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						CATCCTGGATGTCATCACCGT	0.582													21	111					0	0	0	0	A	7605588	A	A	7605588	3	1	303	1	0	0	0	0	1	0	0	0	12224	1377	48	4	840	4	PNPLA6	19	7605588	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	76129	7605588	51523395	657	56184											
LRRC8E	80131	broad.mit.edu	37	chr19	7964455	7964455	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ccttccgttccgtgcgggagGagactggcatgggggacatt	6	9	16	10	3	0	1	0	0	0	1	2	4	2	3	3	5	1	2	3	5	0	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:7964455G>A	uc002mir.2	+	3	1149	c.1048G>A	c.(1048-1050)GAG>AAG	p.E350K		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	350						integral to membrane				lung(1)|pancreas(1)	2						CGTGCGGGAGGAGACTGGCAT	0.562													23	77					0	0	0	0	A	7964455	A	A	7964455	3	1	303	1	0	0	0	0	1	0	0	0	9075	1175	41	2	1054	2	LRRC8E	19	7964455	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	358867	7964455	51164528	658	56185											
LRRC8E	80131	broad.mit.edu	37	chr19	7965769	7965769	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tttaccagggtctgccggcaGaagtgcgggacaagatggag	10	7	16	8	2	1	2	0	0	1	2	1	4	1	4	2	4	3	1	2	4	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:7965769G>A	uc002mir.2	+	3	2463	c.2362G>A	c.(2362-2364)GAA>AAA	p.E788K	MAP2K7_uc002mis.1_5'Flank|MAP2K7_uc002miv.2_5'Flank|MAP2K7_uc010xka.1_5'Flank|MAP2K7_uc002mit.2_5'Flank|MAP2K7_uc010xkb.1_5'Flank|MAP2K7_uc010dvv.2_5'Flank	NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	788						integral to membrane				lung(1)|pancreas(1)	2						TCTGCCGGCAGAAGTGCGGGA	0.567													15	53					0	0	0	0	A	7965769	A	A	7965769	3	1	303	1	0	0	0	0	1	0	0	0	9075	943	33	2	2368	2	LRRC8E	19	7965769	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1314	7965769	51163214	659	56186											
MUC16	94025	broad.mit.edu	37	chr19	9072852	9072852	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	ttgtggtgtcttccatggtgGaggtggtaacatttggagat	7	15	15	4	0	1	1	0	0	1	1	2	3	2	2	1	6	1	1	1	6	1	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:9072852G>T	uc002mkp.2	-	3	14798	c.14594C>A	c.(14593-14595)TCC>TAC	p.S4865Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4867	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCCATGGTGGAGGTGGTAAC	0.453													20	89					3.51602e-12	3.62757e-12	1	0	T	9072852	T	T	9072852	3	4	303	1	0	0	0	0	1	0	0	0	10026	1174	41	2	29257	2	MUC16	19	9072852	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1107083	9072852	50056131	660	56187											
ZNF177	7730	broad.mit.edu	37	chr19	9492159	9492159	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcgatcagtcatcccttaaGaaacacacacgctctcacac	14	8	4	15	2	3	1	3	0	1	1	6	2	4	1	1	0	1	1	1	0	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:9492159G>C	uc002mli.2	+	12	1335	c.672G>C	c.(670-672)AAG>AAC	p.K224N	ZNF177_uc002mlj.2_Missense_Mutation_p.K174N|ZNF177_uc002mlk.2_Missense_Mutation_p.K224N	NM_003451	NP_003442	Q13360	ZN177_HUMAN	zinc finger protein 177	224	C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATCCCTTAAGAAACACACAC	0.463													397	91					0	0	0	0	C	9492159	C	C	9492159	3	2	303	1	0	0	0	0	1	0	0	0	17813	933	33	2	1170	2	ZNF177	19	9492159	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	419307	9492159	49636824	661	56188											
ANGPTL6	83854	broad.mit.edu	37	chr19	10206706	10206706	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacaggcgctccaggcgggcGatgagactgctctgctgggt	6	7	16	12	3	1	1	0	1	1	1	2	3	2	1	1	4	2	3	1	4	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:10206706G>A	uc002mmx.1	-	2	652	c.534C>T	c.(532-534)ATC>ATT	p.I178I	ANGPTL6_uc002mmy.1_Silent_p.I178I	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	178					angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			CCAGGCGGGCGATGAGACTGC	0.697													7	20					0	0	0	0	A	10206706	A	A	10206706	2	1	303	1	0	0	0	0	0	0	0	1	618	1048	37	1		1	ANGPTL6	19	10206706	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	714547	10206706	48922277	662	56189											
ACP5	54	broad.mit.edu	37	chr19	11687266	11687266	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgcgggccagcttcacgtctCggggcctctcaggctgctgg	3	9	15	14	3	3	0	2	0	2	0	5	0	3	0	2	5	3	3	2	5	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:11687266C>T	uc002msg.3	-	4	673	c.527G>A	c.(526-528)CGA>CAA	p.R176Q	ACP5_uc002msh.3_Missense_Mutation_p.R176Q|ACP5_uc002msi.3_Missense_Mutation_p.R176Q|ACP5_uc002msj.3_Missense_Mutation_p.R176Q	NM_001611	NP_001602	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	176					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			central_nervous_system(1)	1						CTTCACGTCTCGGGGCCTCTC	0.597													8	43					0	0	0	0	T	11687266	T	T	11687266	3	4	303	1	0	0	0	0	1	0	0	0	164	884	31	1	458	1	ACP5	19	11687266	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1480560	11687266	47441717	663	56190											
CD97	976	broad.mit.edu	37	chr19	14507944	14507944	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacagctccacccactgcctCaacaacgtgggcagctatca	11	6	7	17	1	2	0	2	0	0	0	3	0	3	0	3	1	5	3	3	1	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:14507944C>T	uc002myl.2	+	6	657	c.534C>T	c.(532-534)CTC>CTT	p.L178L	CD97_uc002mym.2_Intron|CD97_uc002myn.2_Intron	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	178	Extracellular (Potential).|EGF-like 4; calcium-binding (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						CCCACTGCCTCAACAACGTGG	0.607													57	76					0	0	0	0	T	14507944	T	T	14507944	2	4	303	1	0	0	0	0	0	0	0	1	3064	813	29	2		2	CD97	19	14507944	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	2820678	14507944	44621039	664	56191											
ZNF333	84449	broad.mit.edu	37	chr19	14829049	14829049	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcatcgacaggagcaacctCagcctggagaaaaactctat	14	8	8	11	1	3	1	2	0	1	1	4	4	3	2	2	2	4	1	2	2	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:14829049C>T	uc002mzn.2	+	12	1044	c.910C>T	c.(910-912)CAG>TAG	p.Q304*	ZNF333_uc002mzk.3_Nonsense_Mutation_p.Q195*	NM_032433	NP_115809	Q96JL9	ZN333_HUMAN	zinc finger protein 333	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGAGCAACCTCAGCCTGGAGA	0.383													8	31					0	0	0	0	T	14829049	T	T	14829049	4	4	303	1	0	0	0	0	0	1	0	0	17917	827	29	2	952	2	ZNF333	19	14829049	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	321105	14829049	44299934	665	56192											
ILVBL	10994	broad.mit.edu	37	chr19	15226872	15226872	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cctgcaccaactcccagagtCccaaaggcccctaagaggac	12	4	8	17	0	0	2	0	0	0	2	2	3	2	3	6	2	2	1	6	2	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:15226872C>T	uc002nam.2	-	13	1603	c.1482G>A	c.(1480-1482)GGG>GGA	p.G494G	ILVBL_uc010xof.1_Silent_p.G135G|ILVBL_uc010dzw.2_Silent_p.G387G	NM_006844	NP_006835	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	494	Thiamine pyrophosphate binding (By similarity).					integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			ovary(2)	2						CTCCCAGAGTCCCAAAGGCCC	0.617													6	28					0	0	0	0	T	15226872	T	T	15226872	2	4	303	1	0	0	0	0	0	0	0	1	7754	842	30	2		2	ILVBL	19	15226872	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	397823	15226872	43902111	666	56193											
BRD4	23476	broad.mit.edu	37	chr19	15350585	15350585	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagtggatcttctcctccttCaccaccacgaggggctgggg	6	9	13	13	1	3	0	1	0	2	0	5	3	4	1	4	5	0	1	4	5	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:15350585C>T	uc002nar.2	-	16	3552	c.3330G>A	c.(3328-3330)GTG>GTA	p.V1110V		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	1110					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TCTCCTCCTTCACCACCACGA	0.711			T	NUT|C15orf55	lethal midline carcinoma of young people								10	40					0	0	0	0	T	15350585	T	T	15350585	2	4	303	1	0	0	0	0	0	0	0	1	1509	813	29	2		2	BRD4	19	15350585	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	123713	15350585	43778398	667	56194											
CYP4F2	8529	broad.mit.edu	37	chr19	16006318	16006318	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	agctgttccagatggtacctGaggcgttgatgacagaccgg	9	9	14	9	2	0	5	0	3	0	2	1	5	1	5	3	3	2	4	3	3	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:16006318G>A	uc002nbs.1	-	3	391	c.341C>T	c.(340-342)TCA>TTA	p.S114L	CYP4F2_uc010xot.1_5'UTR|CYP4F2_uc010xou.1_Intron	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	114					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						GATGGTACCTGAGGCGTTGAT	0.607													43	181					0	0	0	0	A	16006318	A	A	16006318	3	1	303	1	0	0	0	0	1	0	0	0	4205	1294	45	2	1265	2	CYP4F2	19	16006318	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	655733	16006318	43122665	668	56195											
NDUFA13	51079	broad.mit.edu	37	chr19	19627130	19627130	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caaacggaacttgccgcgtcGaggactgtcgggtcagtatc	9	8	13	11	5	1	0	1	0	0	0	4	3	1	2	1	3	3	1	1	3	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:19627130G>T	uc010xqy.1	+	1	591	c.332G>T	c.(331-333)CGA>CTA	p.R111L	TSSK6_uc002nmq.2_5'Flank|TSSK6_uc002nmr.2_5'Flank|NDUFA13_uc002nms.2_Missense_Mutation_p.R111L|NDUFA13_uc010xqx.1_Missense_Mutation_p.R111L	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	28					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	TTGCCGCGTCGAGGACTGTCG	0.652													11	42					0.00829132	0.00830077	1	0	T	19627130	T	T	19627130	3	4	303	1	0	0	0	0	1	0	0	0	10317	1058	37	3	85	3	NDUFA13	19	19627130	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3620812	19627130	39501853	669	56196											
ZNF714	148206	broad.mit.edu	37	chr19	21300497	21300497	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gagagaaaccctacaaatgtGaagaatgtggcaaagccttt	16	8	10	7	0	0	3	0	1	0	2	0	5	0	3	2	1	3	1	2	1	6	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:21300497G>A	uc002npo.3	+	6	1390	c.1030G>A	c.(1030-1032)GAA>AAA	p.E344K	ZNF714_uc002npl.2_Missense_Mutation_p.E189K|ZNF714_uc010ecp.1_Missense_Mutation_p.E295K|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	344	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTACAAATGTGAAGAATGTGG	0.373													6	11					0	0	0	0	A	21300497	A	A	21300497	3	1	303	1	0	0	0	0	1	0	0	0	18185	1291	45	2	1037	2	ZNF714	19	21300497	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1673367	21300497	37828486	670	56197											
ZNF208	7757	broad.mit.edu	37	chr19	22153504	22153504	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ctcatttgtagagtttctctCcagcatgaattttcttatgt	8	19	6	8	0	3	2	1	1	2	1	5	2	4	2	1	0	1	3	1	0	3	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:22153504C>T	uc002nqp.2	-	7	3634	c.3485G>A	c.(3484-3486)GGA>GAA	p.G1162E	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GAGTTTCTCTCCAGCATGAAT	0.373													3	6					0	0	0	0	T	22153504	T	T	22153504	3	4	303	1	0	0	0	0	1	0	0	0	17833	870	30	2		2	ZNF208	19	22153504	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	853007	22153504	36975479	671	56198											
CCNE1	898	broad.mit.edu	37	chr19	30308113	30308113	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cacctgacaaagaagatgatGaccgggtttacccaaactca	15	7	8	11	1	1	5	1	3	0	2	1	5	1	5	3	1	2	1	3	1	4	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:30308113G>A	uc002nsn.2	+	5	433	c.250G>A	c.(250-252)GAC>AAC	p.D84N	CCNE1_uc002nso.2_Missense_Mutation_p.D69N	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	84					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			AGAAGATGATGACCGGGTTTA	0.532													18	55					0	0	0	0	A	30308113	A	A	30308113	3	1	303	1	0	0	0	0	1	0	0	0	2935	1290	45	2	264	2	CCNE1	19	30308113	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	8154609	30308113	28820870	672	56199											
CATSPERG	57828	broad.mit.edu	37	chr19	38861431	38861431	+	Nonstop_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagagacagttgatgacctGagtgtcccacctgccccagc	9	7	12	13	0	0	4	0	3	0	1	1	6	1	5	5	1	2	1	5	1	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:38861431G>C	uc002oih.3	+	29	3566	c.3479G>C	c.(3478-3480)TGA>TCA	p.*1160S	CATSPERG_uc002oig.3_Nonstop_Mutation_p.*1120S|CATSPERG_uc002oif.3_Nonstop_Mutation_p.*800S|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	1160					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						TTGATGACCTGAGTGTCCCAC	0.572													21	72					0	0	0	0	C	38861431	C	C	38861431	4	2	303	1	0	0	0	0	0	0	0	0	2704	1285	45	2	3589	2	CATSPERG	19	38861431	Nonstop_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	8553318	38861431	20267552	673	56200											
MAP3K10	4294	broad.mit.edu	37	chr19	40719513	40719513	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcagtgccactgcctgccGagccctccccgggggcgcgg	3	6	14	18	4	1	0	1	0	1	0	3	1	2	0	6	3	4	0	6	3	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:40719513G>A	uc002ona.2	+	9	2215	c.1927G>A	c.(1927-1929)GAG>AAG	p.E643K	MAP3K10_uc002onb.2_Missense_Mutation_p.E32K	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	643					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						ACTGCCTGCCGAGCCCTcccc	0.537													14	17					0	0	0	0	A	40719513	A	A	40719513	3	1	303	1	0	0	0	0	1	0	0	0	9297	1059	37	1	1961	1	MAP3K10	19	40719513	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1858082	40719513	18409470	674	56201											
ADCK4	79934	broad.mit.edu	37	chr19	41220510	41220510	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cagctgtccaccggtcccccGaagtaggccccccaccttca	7	6	8	20	2	1	0	1	0	0	0	3	1	3	0	8	2	1	2	8	2	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:41220510G>A	uc002oor.2	-	2	330	c.28C>T	c.(28-30)CGG>TGG	p.R10W	ADCK4_uc002ooq.1_Missense_Mutation_p.R10W|ADCK4_uc002oos.2_Missense_Mutation_p.R10W|ITPKC_uc002oot.2_5'Flank	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	10						integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			CCGGTCCCCCGAAGTAGGCCC	0.652													7	28					0	0	0	0	A	41220510	A	A	41220510	3	1	303	1	0	0	0	0	1	0	0	0	290	1057	37	1	1662	1	ADCK4	19	41220510	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	500997	41220510	17908473	675	56202											
EGLN2	112398	broad.mit.edu	37	chr19	41307102	41307102	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tgggcggtcgcgtgctggccGaggtggaggccctcaaacgg	5	6	19	11	5	1	0	1	0	0	0	2	2	1	1	2	7	2	1	2	7	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:41307102G>A	uc010ehd.2	+	8	1626	c.625G>A	c.(625-627)GAG>AAG	p.E209K	EGLN2_uc002opg.3_Missense_Mutation_p.E209K|EGLN2_uc002oph.2_Missense_Mutation_p.E209K|EGLN2_uc002opi.2_Missense_Mutation_p.E209K	NM_080732	NP_542770	Q96KS0	EGLN2_HUMAN	EGL nine (C.elegans) homolog 2	209					cell redox homeostasis|estrogen receptor signaling pathway|positive regulation of protein catabolic process|regulation of cell growth|response to hypoxia	cytoplasm|nucleus	ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|oxygen sensor activity			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Vitamin C(DB00126)	CGTGCTGGCCGAGGTGGAGGC	0.687													37	97					0	0	0	0	A	41307102	A	A	41307102	3	1	303	1	0	0	0	0	1	0	0	0	4991	1059	37	1	627	1	EGLN2	19	41307102	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	86592	41307102	17821881	676	56203											
CCDC97	90324	broad.mit.edu	37	chr19	41828570	41828570	+	Missense_Mutation	SNP	G	A	A																															atgaggaggagaggtactttGatgaggaagaacctgaggat																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:41828570G>A	uc002oqg.2	+	5	1104	c.982G>A	c.(982-984)GAT>AAT	p.D328N	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	328											0						GAGGTACTTTGATGAGGAAGA	0.617													31	76					0	0	0	0	A	41828570	A	A	41828570	3	1	303	1	0	0	0	0	1	0	0	0	2888	1290	45	2	1000	2	CCDC97	19	41828570	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	521468	41828570	17300413	677	56204	134	2									
CCDC97	90324	broad.mit.edu	37	chr19	41828573	41828573	+	Missense_Mutation	SNP	G	A	A																															aggaggagaggtactttgatGaggaagaacctgaggatgcg																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:41828573G>A	uc002oqg.2	+	5	1107	c.985G>A	c.(985-987)GAG>AAG	p.E329K	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	329											0						GTACTTTGATGAGGAAGAACC	0.617													32	74					0	0	0	0	A	41828573	A	A	41828573	3	1	303	1	0	0	0	0	1	0	0	0	2888	1291	45	2	1003	2	CCDC97	19	41828573	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3	41828573	17300410	678	56205	134	2									
ATP5SL	55101	broad.mit.edu	37	chr19	41944281	41944281	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cccaggcgatggatgcccctGatacgcccattccacatggg	8	7	11	15	2	0	1	0	1	0	0	1	3	1	2	5	3	2	0	5	3	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:41944281G>C	uc002oqw.1	-	2	63	c.57C>G	c.(55-57)ATC>ATG	p.I19M	CYP2F1_uc010xvw.1_Intron|ATP5SL_uc002oqu.1_RNA|ATP5SL_uc002oqv.2_Missense_Mutation_p.I25M|ATP5SL_uc010xwa.1_Missense_Mutation_p.I25M|ATP5SL_uc002oqx.1_Missense_Mutation_p.I19M|ATP5SL_uc002oqy.1_Missense_Mutation_p.I19M|ATP5SL_uc002oqz.1_Missense_Mutation_p.I19M|ATP5SL_uc002ora.1_Missense_Mutation_p.I6M|ATP5SL_uc010xwb.1_Missense_Mutation_p.I25M	NM_018035	NP_060505	Q9NW81	AT5SL_HUMAN	ATP5S-like	19										large_intestine(1)|breast(1)	2						GGATGCCCCTGATACGCCCAT	0.597													8	14					0	0	0	0	C	41944281	C	C	41944281	3	2	303	1	0	0	0	0	1	0	0	0	1166	1280	45	2	736	2	ATP5SL	19	41944281	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	115708	41944281	17184702	679	56206											
POU2F2	5452	broad.mit.edu	37	chr19	42600013	42600013	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aagctcaggttgagggcctcGaagcgggaaatggtcgtctg	9	8	16	8	3	2	1	1	1	1	0	4	3	2	2	1	4	2	2	1	4	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:42600013G>A	uc002osp.2	-	9	799	c.732C>T	c.(730-732)TTC>TTT	p.F244F	POU2F2_uc002osn.2_Silent_p.F228F|POU2F2_uc002oso.2_Silent_p.F17F|POU2F2_uc002osq.2_Silent_p.F228F|POU2F2_uc002osr.1_Silent_p.F244F	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	244	POU-specific.				humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				TGAGGGCCTCGAAGCGGGAAA	0.622													42	75					0	0	0	0	A	42600013	A	A	42600013	2	1	303	1	0	0	0	0	0	0	0	1	12327	1049	37	1		1	POU2F2	19	42600013	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	655732	42600013	16528970	680	56207											
CIC	23152	broad.mit.edu	37	chr19	42795873	42795873	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cccttctcagtacctgtgcaGaatggtgcccagccccccag	7	8	9	17	0	1	1	1	0	1	1	2	1	1	1	6	1	4	2	6	1	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:42795873G>A	uc002otf.1	+	11	2902	c.2862G>A	c.(2860-2862)CAG>CAA	p.Q954Q		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	954	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				TACCTGTGCAGAATGGTGCCC	0.607			T	DUX4	soft tissue sarcoma								24	73					0	0	0	0	A	42795873	A	A	42795873	2	1	303	1	0	0	0	0	0	0	0	1	3439	933	33	2		2	CIC	19	42795873	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	195860	42795873	16333110	681	56208											
CEACAM1	634	broad.mit.edu	37	chr19	43031509	43031509	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aatggcatggattcagtagtGagctgggcagtggtgggcgg	8	9	19	5	1	1	1	1	1	0	0	1	2	1	2	0	6	1	4	0	6	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:43031509G>C	uc002otv.2	-	2	221	c.108C>G	c.(106-108)CTC>CTG	p.L36L	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|CEACAM1_uc002otw.2_Silent_p.L36L|CEACAM1_uc010eij.2_Silent_p.L36L|CEACAM1_uc002otx.2_Silent_p.L36L|CEACAM1_uc002oty.2_Silent_p.L36L|CEACAM1_uc002otz.2_Silent_p.L36L|CEACAM1_uc010eik.2_Silent_p.L36L|CEACAM1_uc002oua.2_Silent_p.L36L|CEACAM1_uc002oub.2_Silent_p.L36L|CEACAM1_uc002ouc.2_Silent_p.L36L	NM_001712	NP_001703	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion	36	Ig-like V-type.|Extracellular (Potential).				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				ovary(1)|central_nervous_system(1)	2		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	ATTCAGTAGTGAGCTGGGCAG	0.498													43	101					0	0	0	0	C	43031509	C	C	43031509	2	2	303	1	0	0	0	0	0	0	0	1	3202	1277	45	2		2	CEACAM1	19	43031509	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	235636	43031509	16097474	682	56209											
PHLDB3	653583	broad.mit.edu	37	chr19	44008099	44008099	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gctgctgccttctcccacttCttcttcctctgcctgctgct	1	16	6	18	0	4	0	0	0	4	0	6	0	5	0	4	0	5	4	4	0	0	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:44008099C>A	uc002own.3	-	2	431	c.172G>T	c.(172-174)GAA>TAA	p.E58*	PHLDB3_uc002owo.2_Nonsense_Mutation_p.E58*	NM_198850	NP_942147	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B,	58											0		Prostate(69;0.0153)				TCTCCCACTTCTTCTTCCTCT	0.697													20	65					1.85244e-09	1.90005e-09	1	0	A	44008099	A	A	44008099	4	1	303	1	0	0	0	0	0	1	0	0	11908	922	32	2	1810	2	PHLDB3	19	44008099	Nonsense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	976590	44008099	15120884	683	56210											
ZNF221	7638	broad.mit.edu	37	chr19	44471229	44471229	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcacaacttcattcccatcaGacatgccatactggagaaaa	15	9	5	12	0	3	2	3	0	0	2	4	3	4	2	2	1	3	0	2	1	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:44471229G>C	uc002oxx.2	+	6	1903	c.1575G>C	c.(1573-1575)CAG>CAC	p.Q525H	ZNF221_uc010ejb.1_Missense_Mutation_p.Q525H|ZNF221_uc010xws.1_Missense_Mutation_p.Q525H	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	525	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				ATTCCCATCAGACATGCCATA	0.433													20	42					0	0	0	0	C	44471229	C	C	44471229	3	2	303	1	0	0	0	0	1	0	0	0	17842	933	33	2	1589	2	ZNF221	19	44471229	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	463130	44471229	14657754	684	56211											
ZNF230	7773	broad.mit.edu	37	chr19	44513041	44513041	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtaccaagacgtgatgcttGagaacttcacgaacctgctg	11	10	10	10	2	1	3	1	2	0	2	1	5	1	3	2	0	5	3	2	0	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:44513041G>C	uc002oyb.1	+	3	366	c.115G>C	c.(115-117)GAG>CAG	p.E39Q		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CGTGATGCTTGAGAACTTCAC	0.527													44	69					0	0	0	0	C	44513041	C	C	44513041	3	2	303	1	0	0	0	0	1	0	0	0	17851	1291	45	2	121	2	ZNF230	19	44513041	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	41812	44513041	14615942	685	56212											
ZNF233	353355	broad.mit.edu	37	chr19	44778014	44778014	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gagagagagcctgtaaatgtGatgtatatgataaaggcttc	14	11	12	4	0	0	4	0	2	0	2	1	6	0	4	1	1	1	3	1	1	6	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:44778014G>C	uc002oyz.1	+	5	1328	c.1201G>C	c.(1201-1203)GAT>CAT	p.D401H	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.D216H	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	401	C2H2-type 5; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				CTGTAAATGTGATGTATATGA	0.438													13	39					0	0	0	0	C	44778014	C	C	44778014	3	2	303	1	0	0	0	0	1	0	0	0	17853	1290	45	2	1215	2	ZNF233	19	44778014	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	264973	44778014	14350969	686	56213											
ZNF285	26974	broad.mit.edu	37	chr19	44891631	44891631	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	catactggtcacatttataaGatttttctcctaggtgagtg	10	16	8	7	0	2	2	1	1	1	1	3	2	2	2	1	2	1	0	1	2	4	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:44891631G>C	uc002ozd.3	-	4	863	c.776C>G	c.(775-777)TCT>TGT	p.S259C	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.S266C	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						ACATTTATAAGATTTTTCTCC	0.418													36	75					0	0	0	0	C	44891631	C	C	44891631	3	2	303	1	0	0	0	0	1	0	0	0	17889	942	33	2	1000	2	ZNF285	19	44891631	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	113617	44891631	14237352	687	56214											
RELB	5971	broad.mit.edu	37	chr19	45515293	45515293	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cctggtgtctcgcggggctgCgtccctgagcacggtcaccc	3	8	14	16	4	2	1	1	1	1	0	4	1	3	1	3	4	2	2	3	4	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:45515293C>T	uc002paj.1	+	5	389	c.263C>T	c.(262-264)GCG>GTG	p.A88V		NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	88						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		CGCGGGGCTGCGTCCCTGAGC	0.746													4	15					0	0	0	0	T	45515293	T	T	45515293	3	4	303	1	0	0	0	0	1	0	0	0	13282	768	27	1	269	1	RELB	19	45515293	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	623662	45515293	13613690	688	56215											
ZC3H4	23211	broad.mit.edu	37	chr19	47572471	47572471	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gggctgagggcaggaagtcaGggacaccggcgcctggcttc	7	5	18	11	2	1	1	1	1	0	0	2	3	1	3	2	6	0	3	2	6	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:47572471G>T	uc002pga.3	-	14	2314	c.2276C>A	c.(2275-2277)CCT>CAT	p.P759H	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	759							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CAGGAAGTCAGGGACACCGGC	0.682													10	29					4.68919e-08	4.79291e-08	1	0	T	47572471	T	T	47572471	3	4	303	1	0	0	0	0	1	0	0	0	17637	1000	35	4	1643	4	ZC3H4	19	47572471	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	2057178	47572471	11556512	689	56216											
ZC3H4	23211	broad.mit.edu	37	chr19	47572518	47572518	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cctgggggccctccctcagaGaagctgtcgggctccagagg	6	6	15	14	1	1	2	1	0	0	2	4	3	3	2	4	4	1	2	4	4	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:47572518G>C	uc002pga.3	-	14	2267	c.2229C>G	c.(2227-2229)TTC>TTG	p.F743L	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	743							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CTCCCTCAGAGAAGCTGTCGG	0.672													5	11					0	0	0	0	C	47572518	C	C	47572518	3	2	303	1	0	0	0	0	1	0	0	0	17637	933	33	2	1690	2	ZC3H4	19	47572518	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	47	47572518	11556465	690	56217											
BAX	581	broad.mit.edu	37	chr19	49459487	49459487	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cgtggacacagactccccccGagaggtctttttccgagtgg	7	9	12	13	3	1	2	0	0	1	2	3	5	3	3	4	3	0	0	4	3	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:49459487G>A	uc002plk.2	+	4	335	c.266G>A	c.(265-267)CGA>CAA	p.R89Q	BAX_uc002plf.1_Missense_Mutation_p.R89Q|BAX_uc002plg.1_Missense_Mutation_p.R52Q|BAX_uc002plh.1_Missense_Mutation_p.R11Q|BAX_uc010xzx.1_RNA|BAX_uc002plj.2_Missense_Mutation_p.R89Q|BAX_uc002pll.2_Missense_Mutation_p.R40Q|BAX_uc002plm.2_Missense_Mutation_p.R11Q	NM_138761	NP_620116	Q07812	BAX_HUMAN	BCL2-associated X protein isoform alpha	89					activation of caspase activity by cytochrome c|activation of pro-apoptotic gene products|B cell apoptosis|cleavage of lamin|DNA fragmentation involved in apoptotic nuclear change|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|induction of retinal programmed cell death|mitochondrial fragmentation involved in apoptosis|mitochondrial fusion|negative regulation of protein binding|negative regulation of survival gene product expression|nuclear fragmentation involved in apoptotic nuclear change|positive regulation of neuron apoptosis|protein homooligomerization|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria|release of matrix enzymes from mitochondria|response to toxin|transformed cell apoptosis	cytosol|endoplasmic reticulum membrane|mitochondrial outer membrane|mitochondrial permeability transition pore complex|nucleus	BH3 domain binding|channel activity|lipid binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000159)|all cancers(93;0.00047)|GBM - Glioblastoma multiforme(486;0.018)|Epithelial(262;0.0279)		GACTCCCCCCGAGAGGTCTTT	0.577													37	78					0	0	0	0	A	49459487	A	A	49459487	3	1	303	1	0	0	0	0	1	0	0	0	1330	1058	37	1	280	1	BAX	19	49459487	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1886969	49459487	9669496	691	56218											
TEAD2	8463	broad.mit.edu	37	chr19	49850456	49850456	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagaactcacccagaacttGaccaggaagaaggcatgggg	14	5	13	9	0	1	4	1	2	0	3	1	6	1	5	2	4	2	1	2	4	4	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:49850456G>C	uc002pnj.2	-	9	991	c.900C>G	c.(898-900)GTC>GTG	p.V300V	TEAD2_uc002png.2_Silent_p.V303V|TEAD2_uc002pnh.2_Silent_p.V304V|TEAD2_uc002pni.2_Silent_p.V303V|TEAD2_uc010yao.1_Silent_p.V172V|TEAD2_uc010emw.2_Silent_p.V303V	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	300	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		CCCAGAACTTGACCAGGAAGA	0.547													42	154					0	0	0	0	C	49850456	C	C	49850456	2	2	303	1	0	0	0	0	0	0	0	1	15805	1277	45	2		2	TEAD2	19	49850456	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	390969	49850456	9278527	692	56219											
CPT1C	126129	broad.mit.edu	37	chr19	50204037	50204037	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcacactgcacgtggccctGaggctgcttctgtcctacca	6	11	9	15	1	2	1	1	1	1	0	3	1	3	1	3	2	3	3	3	2	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:50204037G>A	uc002ppj.2	+	4	583	c.378G>A	c.(376-378)CTG>CTA	p.L126L	CPT1C_uc002ppl.3_Silent_p.L126L|CPT1C_uc002ppi.2_Silent_p.L43L|CPT1C_uc002ppk.2_Silent_p.L126L|CPT1C_uc010eng.2_Silent_p.L126L|CPT1C_uc010enh.2_Silent_p.L126L|CPT1C_uc010ybc.1_Intron	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	126	Helical; (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		ACGTGGCCCTGAGGCTGCTTC	0.657													57	174					0	0	0	0	A	50204037	A	A	50204037	2	1	303	1	0	0	0	0	0	0	0	1	3848	1277	45	2		2	CPT1C	19	50204037	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	353581	50204037	8924946	693	56220											
GPR32	2854	broad.mit.edu	37	chr19	51274298	51274298	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atctctgtcctctaccccgtCtgggccctgaaccaccgcac	6	9	7	19	2	3	1	0	1	3	0	5	1	4	1	6	1	2	1	6	1	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:51274298C>G	uc010ycf.1	+	1	441	c.441C>G	c.(439-441)GTC>GTG	p.V147V		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	147	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TCTACCCCGTCTGGGCCCTGA	0.592													26	102					0	0	0	0	G	51274298	G	G	51274298	2	3	303	1	0	0	0	0	0	0	0	1	6726	900	32	2		2	GPR32	19	51274298	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1070261	51274298	7854685	694	56221											
ZNF649	65251	broad.mit.edu	37	chr19	52395143	52395143	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgcagatgatcatcagctttCtcaatttctaagagagagaa	14	12	8	7	0	4	4	3	1	2	3	5	6	4	4	0	0	2	2	0	0	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:52395143C>G	uc002pxy.2	-	5	514	c.246G>C	c.(244-246)GAG>GAC	p.E82D	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	82					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CATCAGCTTTCTCAATTTCTA	0.408													9	25					0	0	0	0	G	52395143	G	G	52395143	3	3	303	1	0	0	0	0	1	0	0	0	18131	912	32	2	1275	2	ZNF649	19	52395143	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1120845	52395143	6733840	695	56222											
ZNF808	388558	broad.mit.edu	37	chr19	53058363	53058363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgtagaattcatagtggtGagaaaccttacaagtgtagt	14	12	10	5	1	1	2	1	1	0	2	2	3	1	2	1	1	2	2	1	1	7	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:53058363G>A	uc010epq.1	+	5	2371	c.2194G>A	c.(2194-2196)GAG>AAG	p.E732K	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	732					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TCATAGTGGTGAGAAACCTTA	0.433													38	124					0	0	0	0	A	53058363	A	A	53058363	3	1	303	1	0	0	0	0	1	0	0	0	18240	1291	45	2	2204	2	ZNF808	19	53058363	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	663220	53058363	6070620	696	56223											
CNOT3	4849	broad.mit.edu	37	chr19	54656013	54656013	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atggcggaacgggcagccatCagctctggcattgaggaccc	9	6	14	12	2	2	1	1	1	1	0	2	3	2	3	2	5	3	3	2	5	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:54656013C>G	uc002qdj.1	+	14	1967	c.1656C>G	c.(1654-1656)ATC>ATG	p.I552M	CNOT3_uc010yel.1_Missense_Mutation_p.I552M|CNOT3_uc002qdi.2_Missense_Mutation_p.I465M|CNOT3_uc002qdk.1_Missense_Mutation_p.I552M|CNOT3_uc010ere.1_RNA|CNOT3_uc002qdl.2_Missense_Mutation_p.I7M	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	552	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGGCAGCCATCAGCTCTGGCA	0.647													25	42					0	0	0	0	G	54656013	G	G	54656013	3	3	303	1	0	0	0	0	1	0	0	0	3635	816	29	2	1706	2	CNOT3	19	54656013	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1597650	54656013	4472970	697	56224											
LILRA6	79168	broad.mit.edu	37	chr19	54745500	54745500	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	ggggtgggaccacacccgggGggtgtttgtataatagtaat	9	10	16	6	1	0	0	0	0	0	0	0	1	0	1	2	6	0	3	2	6	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:54745500G>T	uc002qeu.1	-	4	734	c.610C>A	c.(610-612)CCC>ACC	p.P204T	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Missense_Mutation_p.P204T|LILRA6_uc002qek.1_Missense_Mutation_p.P204T|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Missense_Mutation_p.P204T|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Missense_Mutation_p.P204T|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Missense_Mutation_p.P204T|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.P204T|LILRA6_uc010yep.1_Missense_Mutation_p.P204T|LILRA6_uc010yeq.1_Missense_Mutation_p.P204T|LILRA6_uc002qet.3_Intron|LILRA6_uc002qev.1_Missense_Mutation_p.P65T	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	204	Extracellular (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CACACCCGGGGGGTGTTTGTA	0.617													46	130					1.91693e-13	1.98474e-13	1	0	T	54745500	T	T	54745500	3	4	303	1	0	0	0	0	1	0	0	0	8830	1232	43	4	855	4	LILRA6	19	54745500	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	89487	54745500	4383483	698	56225											
RPL28	6158	broad.mit.edu	37	chr19	55897785	55897785	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tccagtttcctgatcaagagGaataagcagacctacagcac	14	8	8	11	0	1	3	1	1	0	2	3	4	3	4	3	1	3	3	3	1	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:55897785G>T	uc002qkv.2	+	2	102	c.60G>T	c.(58-60)AGG>AGT	p.R20S	uc002qku.2_5'Flank|RPL28_uc010yfz.1_Missense_Mutation_p.R20S|RPL28_uc010yfy.1_Missense_Mutation_p.R20S|RPL28_uc010yga.1_Missense_Mutation_p.R20S|RPL28_uc010ygb.1_Missense_Mutation_p.R20S|RPL28_uc002qkw.1_Missense_Mutation_p.R20S	NM_000991	NP_000982	P46779	RL28_HUMAN	ribosomal protein L28 isoform 2	20					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0	Breast(117;0.191)	Renal(1328;0.245)	LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		TGATCAAGAGGAATAAGCAGA	0.607													9	16					0.000978159	0.000984889	1	0	T	55897785	T	T	55897785	3	4	303	1	0	0	0	0	1	0	0	0	13642	1165	41	2	62	2	RPL28	19	55897785	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1152285	55897785	3231198	699	56226											
NLRP11	204801	broad.mit.edu	37	chr19	56303677	56303677	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggagacttactgaagctcctCtaactgacaggttggaaaca	13	9	10	9	0	1	3	0	2	1	1	2	5	2	4	1	3	4	2	1	3	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:56303677C>G	uc010ygf.1	-	9	3214	c.2503G>C	c.(2503-2505)GAG>CAG	p.E835Q	NLRP11_uc002qlz.2_Missense_Mutation_p.E682Q|NLRP11_uc002qmb.2_Missense_Mutation_p.E736Q|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	835							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TGAAGCTCCTCTAACTGACAG	0.488													26	46					0	0	0	0	G	56303677	G	G	56303677	3	3	303	1	0	0	0	0	1	0	0	0	10527	922	32	2	614	2	NLRP11	19	56303677	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	405892	56303677	2825306	700	56227											
ZIM3	114026	broad.mit.edu	37	chr19	57646835	57646835	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgttgaatgagggttgagttCtgcctgaaggatttctcaca	9	14	12	6	0	2	4	1	4	2	0	3	5	2	5	1	2	1	3	1	2	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:57646835C>G	uc002qnz.1	-	5	1256	c.870G>C	c.(868-870)CAG>CAC	p.Q290H		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	290	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGGTTGAGTTCTGCCTGAAGG	0.373													26	71					0	0	0	0	G	57646835	G	G	57646835	3	3	303	1	0	0	0	0	1	0	0	0	17752	912	32	2	552	2	ZIM3	19	57646835	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1343158	57646835	1482148	701	56228											
ZSCAN22	342945	broad.mit.edu	37	chr19	58846211	58846211	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgagcccagtgccgtgggaaGaggacagcttccttcaagtg	9	8	14	10	1	1	2	1	1	0	1	2	4	2	4	3	2	3	1	3	2	2	2	rs143306274	byFrequency	TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr19:58846211G>C	uc002qsc.2	+	2	190	c.43G>C	c.(43-45)GAG>CAG	p.E15Q	ZSCAN22_uc010yhz.1_Missense_Mutation_p.E15Q	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	15					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GCCGTGGGAAGAGGACAGCTT	0.617													14	39					0	0	0	0	C	58846211	C	C	58846211	3	2	303	1	0	0	0	0	1	0	0	0	18301	943	33	2	45	2	ZSCAN22	19	58846211	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1199376	58846211	282772	702	56229											
NSFL1C	55968	broad.mit.edu	37	chr20	1438855	1438855	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gaagactcacctctggccttCctcttcctcctcatcttcat	6	14	4	17	0	6	1	3	0	3	1	9	2	9	1	5	1	0	0	5	1	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:1438855C>T	uc002wfc.2	-	3	1216	c.268G>A	c.(268-270)GAA>AAA	p.E90K	NSFL1C_uc002wfd.2_Silent_p.R10R|NSFL1C_uc002wfe.2_Missense_Mutation_p.E90K|NSFL1C_uc002wff.2_RNA	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	90	Poly-Glu.					chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						CTCTGGCCTTCCTCTTCCTCC	0.478													28	73					0	0	0	0	T	1438855	T	T	1438855	3	4	303	1	0	0	0	0	1	0	0	0	10726	864	30	2	872	2	NSFL1C	20	1438855	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08		1438855	61586665	703	56230											
SIRPA	140885	broad.mit.edu	37	chr20	1918023	1918023	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	ccaaggggaagaagcctgctCcccaggctgcggagcccaac	10	3	13	15	1	0	1	0	0	0	1	1	3	1	3	5	4	5	2	5	4	4	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:1918023C>T	uc002wfq.2	+	9	1684	c.1324C>T	c.(1324-1326)CCC>TCC	p.P442S	SIRPA_uc010zps.1_Missense_Mutation_p.P422S|SIRPA_uc002wfr.2_Missense_Mutation_p.P442S|SIRPA_uc002wfs.2_Missense_Mutation_p.P442S|SIRPA_uc002wft.2_Missense_Mutation_p.P446S	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	442	Cytoplasmic (Potential).|SH3-binding (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GAAGCCTGCTCCCCAGGCTGC	0.542													14	38					0	0	0	0	T	1918023	T	T	1918023	3	4	303	1	0	0	0	0	1	0	0	0	14397	855	30	2	1354	2	SIRPA	20	1918023	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	479168	1918023	61107497	704	56231											
PDYN	5173	broad.mit.edu	37	chr20	1961355	1961355	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gagacccctgagcttctcctCcaggctcttgctcagagtgt	6	11	10	14	0	3	3	1	1	2	2	5	4	4	3	4	1	2	3	4	1	0	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:1961355C>T	uc010gaj.2	-	3	621	c.379G>A	c.(379-381)GAG>AAG	p.E127K	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.E127K|PDYN_uc010zpt.1_Intron	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	127					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						AGCTTCTCCTCCAGGCTCTTG	0.547													23	58					0	0	0	0	T	1961355	T	T	1961355	3	4	303	1	0	0	0	0	1	0	0	0	11753	864	30	2	389	2	PDYN	20	1961355	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	43332	1961355	61064165	705	56232											
PTPRA	5786	broad.mit.edu	37	chr20	3008372	3008372	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	gggctaccggcagaaggactCctatatcgccagccagggcc	9	5	13	14	2	0	1	0	0	0	1	2	2	1	2	5	4	2	2	5	4	4	3	rs138028158	byFrequency	TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:3008372C>G	uc010zqd.1	+	19	2155	c.1838C>G	c.(1837-1839)TCC>TGC	p.S613C	PTPRA_uc002whj.2_Missense_Mutation_p.S602C|PTPRA_uc002whk.2_Missense_Mutation_p.S593C|PTPRA_uc002whl.2_Missense_Mutation_p.S593C|PTPRA_uc002whm.2_Missense_Mutation_p.S369C|PTPRA_uc002whn.2_Missense_Mutation_p.S593C|PTPRA_uc002who.2_Missense_Mutation_p.S265C	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	602	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						CAGAAGGACTCCTATATCGCC	0.517													7	35					0	0	0	0	G	3008372	G	G	3008372	3	3	303	1	0	0	0	0	1	0	0	0	12860	855	30	2	1871	2	PTPRA	20	3008372	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1047017	3008372	60017148	706	56233											
SIGLEC1	6614	broad.mit.edu	37	chr20	3682042	3682042	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttccaagggagttggtggctGagcacttgtactccccactg	7	11	12	11	0	0	1	0	1	0	0	2	2	2	2	3	3	2	4	3	3	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:3682042G>A	uc002wja.2	-	6	1475	c.1475C>T	c.(1474-1476)TCA>TTA	p.S492L	SIGLEC1_uc002wiz.3_Missense_Mutation_p.S492L	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	492	Ig-like C2-type 4.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GTTGGTGGCTGAGCACTTGTA	0.587													11	38					0	0	0	0	A	3682042	A	A	3682042	3	1	303	1	0	0	0	0	1	0	0	0	14370	1294	45	2	3718	2	SIGLEC1	20	3682042	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	673670	3682042	59343478	707	56234											
PANK2	80025	broad.mit.edu	37	chr20	3893244	3893244	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atatttatggaggggactatGagaggtttggactgccaggc	10	11	15	5	0	0	1	0	1	0	1	0	5	0	4	1	6	1	1	1	6	3	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:3893244G>C	uc002wkc.2	+	4	1381	c.1375G>C	c.(1375-1377)GAG>CAG	p.E459Q	PANK2_uc002wkb.2_Missense_Mutation_p.E168Q|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_Missense_Mutation_p.E168Q|PANK2_uc002wkf.2_Missense_Mutation_p.E23Q	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	459					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						AGGGGACTATGAGAGGTTTGG	0.408													24	42					0	0	0	0	C	3893244	C	C	3893244	3	2	303	1	0	0	0	0	1	0	0	0	11471	1291	45	2	1389	2	PANK2	20	3893244	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	211202	3893244	59132276	708	56235											
SLC23A2	9962	broad.mit.edu	37	chr20	4866542	4866542	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaatgcaaaagcactggcctGaaacaggggtaacctaaaag	18	5	10	8	0	0	1	0	1	0	0	0	1	0	1	2	3	4	3	2	3	7	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:4866542G>C	uc002wlg.1	-	7	871	c.496C>G	c.(496-498)CAG>GAG	p.Q166E	SLC23A2_uc010zqr.1_Intron|SLC23A2_uc002wlh.1_Missense_Mutation_p.Q166E|SLC23A2_uc002wli.2_Missense_Mutation_p.Q165E	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	166	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						GCACTGGCCTGAAACAGGGGT	0.433													8	15					0	0	0	0	C	4866542	C	C	4866542	3	2	303	1	0	0	0	0	1	0	0	0	14527	1299	45	2	1500	2	SLC23A2	20	4866542	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	973298	4866542	58158978	709	56236											
PCNA	5111	broad.mit.edu	37	chr20	5100331	5100331	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	acgtgggacgagtccatgctCtgcaggtttacaccgctgga	8	9	13	11	3	1	0	0	0	1	0	2	3	2	2	2	3	3	4	2	3	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:5100331C>T	uc002wlp.2	-	1	317	c.114G>A	c.(112-114)CAG>CAA	p.Q38Q	PCNA_uc002wlq.2_Silent_p.Q38Q|PCNA_uc010zqs.1_Silent_p.Q38Q	NM_182649	NP_872590	P12004	PCNA_HUMAN	proliferating cell nuclear antigen	38	Interaction with NUDT15.				cell proliferation|DNA strand elongation involved in DNA replication|mismatch repair|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|positive regulation of deoxyribonuclease activity|regulation of DNA replication|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair|translesion synthesis	cytoplasm|DNA replication factor C complex|microtubule cytoskeleton|nuclear replication fork|nucleoplasm|PCNA complex|PCNA-p21 complex	dinucleotide insertion or deletion binding|DNA polymerase processivity factor activity|MutLalpha complex binding|purine-specific mismatch base pair DNA N-glycosylase activity			lung(1)	1						AGTCCATGCTCTGCAGGTTTA	0.607								DNA_polymerases_(catalytic_subunits)					4	11					0	0	0	0	T	5100331	T	T	5100331	2	4	303	1	0	0	0	0	0	0	0	1	11642	912	32	2		2	PCNA	20	5100331	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	233789	5100331	57925189	710	56237											
C20orf72	92667	broad.mit.edu	37	chr20	17956539	17956539	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gtctgctggactgtgtggctGagtatcagtaagtatgagat	9	13	14	5	0	2	2	1	2	1	1	2	4	2	3	0	2	1	5	0	2	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:17956539G>A	uc002wqh.2	+	3	806	c.724G>A	c.(724-726)GAG>AAG	p.E242K	C20orf72_uc010gco.2_Intron|C20orf72_uc010gcp.2_RNA	NM_052865	NP_443097	Q9BQP7	CT072_HUMAN	hypothetical protein LOC92667	242											0						CTGTGTGGCTGAGTATCAGTA	0.443													15	43					0	0	0	0	A	17956539	A	A	17956539	3	1	303	1	0	0	0	0	1	0	0	0	2128	1291	45	2	730	2	C20orf72	20	17956539	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	12856208	17956539	45068981	711	56238											
NAPB	63908	broad.mit.edu	37	chr20	23358024	23358024	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaaaacatttcattttaggtCtccatctccttctccatccc	10	15	2	14	0	4	0	1	0	3	0	8	0	5	0	4	1	1	0	4	1	3	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:23358024C>G	uc002wta.2	-	11	1003	c.886G>C	c.(886-888)GAC>CAC	p.D296H	NAPB_uc002wtc.2_Missense_Mutation_p.D202H|NAPB_uc002wtb.2_Missense_Mutation_p.D300H|NAPB_uc002wtd.3_RNA|NAPB_uc010zss.1_Missense_Mutation_p.D183H|NAPB_uc010zst.1_Missense_Mutation_p.D257H	NM_022080	NP_071363	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment	296					intracellular protein transport|vesicle-mediated transport	membrane				ovary(1)	1	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)					CATTTTAGGTCTCCATCTCCT	0.428													5	13					0	0	0	0	G	23358024	G	G	23358024	3	3	303	1	0	0	0	0	1	0	0	0	10215	913	32	2	14	2	NAPB	20	23358024	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	5401485	23358024	39667496	712	56239											
PXMP4	11264	broad.mit.edu	37	chr20	32295530	32295530	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cattaattggagggacggctCttgttatagacgaggaagtc	11	11	13	6	2	1	1	0	0	1	1	2	5	1	4	0	4	0	2	0	4	4	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:32295530C>G	uc002wzv.2	-	4	744	c.621G>C	c.(619-621)AAG>AAC	p.K207N	PXMP4_uc002wzw.2_3'UTR|PXMP4_uc010zuh.1_3'UTR	NM_007238	NP_009169	Q9Y6I8	PXMP4_HUMAN	peroxisomal membrane protein 4 isoform a	207						integral to membrane|membrane fraction|mitochondrial inner membrane|peroxisomal membrane	protein transporter activity				0						AGGGACGGCTCTTGTTATAGA	0.537													36	74					0	0	0	0	G	32295530	G	G	32295530	3	3	303	1	0	0	0	0	1	0	0	0	12916	912	32	2	21	2	PXMP4	20	32295530	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	8937506	32295530	30729990	713	56240											
NCOA6	23054	broad.mit.edu	37	chr20	33329793	33329793	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	attctggcaatcactgtcctGaggcacattcaagctctcct	9	12	7	13	0	4	1	2	1	2	0	6	1	5	1	2	2	1	3	2	2	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:33329793G>A	uc002xav.2	-	12	6838	c.4267C>T	c.(4267-4269)CAG>TAG	p.Q1423*	NCOA6_uc002xaw.2_Nonsense_Mutation_p.Q1423*	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1423					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						TCACTGTCCTGAGGCACATTC	0.463													24	27					0	0	0	0	A	33329793	A	A	33329793	4	1	303	1	0	0	0	0	0	1	0	0	10287	1299	45	2	1944	2	NCOA6	20	33329793	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1034263	33329793	29695727	714	56241											
MYH7B	57644	broad.mit.edu	37	chr20	33588931	33588931	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	caggccgccctccgtggcggGaagaagcaggtgcagaagct	9	4	16	12	3	0	2	0	0	0	2	1	3	1	3	3	4	3	3	3	4	3	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:33588931G>A	uc002xbi.1	+	39	5663	c.5571G>A	c.(5569-5571)GGG>GGA	p.G1857G		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1815	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TCCGTGGCGGGAAGAAGCAGG	0.657													9	12					0	0	0	0	A	33588931	A	A	33588931	2	1	303	1	0	0	0	0	0	0	0	1	10093	1161	41	2		2	MYH7B	20	33588931	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	259138	33588931	29436589	715	56242											
CEP250	11190	broad.mit.edu	37	chr20	34067824	34067824	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagtgaggtgcctgaagctgGaactggacactgaacggagt	12	7	15	7	1	0	3	0	3	0	0	0	6	0	6	1	4	4	1	1	4	4	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:34067824G>A	uc002xcm.2	+	21	3111	c.2440G>A	c.(2440-2442)GAA>AAA	p.E814K	CEP250_uc010zve.1_Missense_Mutation_p.E182K	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	814	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CCTGAAGCTGGAACTGGACAC	0.582													21	74					0	0	0	0	A	34067824	A	A	34067824	3	1	303	1	0	0	0	0	1	0	0	0	3267	1175	41	2	2506	2	CEP250	20	34067824	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	478893	34067824	28957696	716	56243											
EPB41L1	2036	broad.mit.edu	37	chr20	34797520	34797520	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	caggagagggacacggtgttCctgaaggacaaccacctggc	11	5	14	11	1	0	2	0	1	0	1	1	5	1	4	3	5	1	1	3	5	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:34797520C>T	uc002xfb.2	+	15	1950	c.1779C>T	c.(1777-1779)TTC>TTT	p.F593F	EPB41L1_uc002xeu.2_Silent_p.F519F|EPB41L1_uc010zvo.1_Silent_p.F593F|EPB41L1_uc002xev.2_Silent_p.F593F|EPB41L1_uc002xew.2_Silent_p.F484F|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Silent_p.F519F|EPB41L1_uc010gfq.2_Silent_p.F692F	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	593					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					ACACGGTGTTCCTGAAGGACA	0.607													8	33					0	0	0	0	T	34797520	T	T	34797520	2	4	303	1	0	0	0	0	0	0	0	1	5176	854	30	2		2	EPB41L1	20	34797520	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	729696	34797520	28228000	717	56244											
NDRG3	57446	broad.mit.edu	37	chr20	35317187	35317187	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agttgtttctatatcatgttCctgtaacaagagaatgtaag	13	15	8	5	0	2	1	1	0	1	1	3	2	3	1	1	0	1	5	1	0	6	7			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:35317187C>G	uc002xfw.2	-	4	176	c.94G>C	c.(94-96)GAA>CAA	p.E32Q	NDRG3_uc002xfx.2_Missense_Mutation_p.E20Q|NDRG3_uc010zvq.1_Intron|NDRG3_uc010zvr.1_Intron	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	32				E -> G (in Ref. 3; AAL08807).	cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)				ATATCATGTTCCTGTAACAAG	0.423													25	50					0	0	0	0	G	35317187	G	G	35317187	3	3	303	1	0	0	0	0	1	0	0	0	10307	869	30	2	1085	2	NDRG3	20	35317187	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	519667	35317187	27708333	718	56245											
KIAA1755	85449	broad.mit.edu	37	chr20	36846669	36846669	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agcctggaggaagaagttctCaaattctgcgtgggctttct	9	12	12	8	1	3	1	1	0	3	1	4	3	3	3	1	3	2	2	1	3	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:36846669C>G	uc002xhy.1	-	12	2928	c.2656G>C	c.(2656-2658)GAG>CAG	p.E886Q	KIAA1755_uc002xhv.1_5'Flank|KIAA1755_uc002xhw.1_5'Flank|KIAA1755_uc002xhx.1_Missense_Mutation_p.E164Q	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	886										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				AAGAAGTTCTCAAATTCTGCG	0.577													16	38					0	0	0	0	G	36846669	G	G	36846669	3	3	303	1	0	0	0	0	1	0	0	0	8296	835	29	2	958	2	KIAA1755	20	36846669	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1529482	36846669	26178851	719	56246											
LBP	3929	broad.mit.edu	37	chr20	36993286	36993286	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	accctccttgctgcagtcatGagccttcctgaggaacacaa	10	9	8	14	0	1	2	1	2	0	0	3	3	3	3	4	1	4	2	4	1	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:36993286G>A	uc002xic.1	+	8	836	c.801G>A	c.(799-801)ATG>ATA	p.M267I		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	267				VMSLP -> A (in Ref. 1; AAA59493).	acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				CTGCAGTCATGAGCCTTCCTG	0.463													33	76					0	0	0	0	A	36993286	A	A	36993286	3	1	303	1	0	0	0	0	1	0	0	0	8691	1290	45	2	831	2	LBP	20	36993286	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	146617	36993286	26032234	720	56247											
HNF4A	3172	broad.mit.edu	37	chr20	43043206	43043206	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcgaagaagattgccagcatCgcagatgtgtgtgagtccat	11	9	13	8	2	0	4	0	1	0	3	2	5	1	4	2	0	2	2	2	0	2	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:43043206C>G	uc002xma.2	+	5	641	c.552C>G	c.(550-552)ATC>ATG	p.I184M	HNF4A_uc002xlt.2_Missense_Mutation_p.I162M|HNF4A_uc002xlu.2_Missense_Mutation_p.I162M|HNF4A_uc002xlv.2_Missense_Mutation_p.I162M|HNF4A_uc002xly.2_Missense_Mutation_p.I184M|HNF4A_uc002xlz.2_Missense_Mutation_p.I184M|HNF4A_uc010ggq.2_Missense_Mutation_p.I177M	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	184					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TTGCCAGCATCGCAGATGTGT	0.572													12	37					0	0	0	0	G	43043206	G	G	43043206	3	3	303	1	0	0	0	0	1	0	0	0	7292	874	31	3	623	3	HNF4A	20	43043206	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6049920	43043206	19982314	721	56248											
ZSWIM3	140831	broad.mit.edu	37	chr20	44506830	44506830	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actctcaccaggttagcaaaGatggctgtagctgcagctgt	10	10	11	10	0	1	1	1	0	1	1	2	1	1	1	1	2	4	7	1	2	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:44506830G>C	uc002xqd.2	+	2	1836	c.1633G>C	c.(1633-1635)GAT>CAT	p.D545H	ZSWIM3_uc010zxg.1_Missense_Mutation_p.D539H	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	545	SWIM-type.						zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				GGTTAGCAAAGATGGCTGTAG	0.557													14	41					0	0	0	0	C	44506830	C	C	44506830	3	2	303	1	0	0	0	0	1	0	0	0	18309	942	33	2	1639	2	ZSWIM3	20	44506830	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	1463624	44506830	18518690	722	56249											
ZNF335	63925	broad.mit.edu	37	chr20	44588038	44588038	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcttcttgtgccgtgtgctGaagtggcagtactcacaggc	6	13	12	10	1	3	1	1	1	2	0	3	1	3	1	1	2	3	3	1	2	2	4			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:44588038G>A	uc002xqw.2	-	15	2178	c.2055C>T	c.(2053-2055)TTC>TTT	p.F685F	ZNF335_uc010zxk.1_Silent_p.F530F	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	685	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				GCCGTGTGCTGAAGTGGCAGT	0.637													6	17					0	0	0	0	A	44588038	A	A	44588038	2	1	303	1	0	0	0	0	0	0	0	1	17919	1281	45	2		2	ZNF335	20	44588038	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	81208	44588038	18437482	723	56250											
FAM65C	140876	broad.mit.edu	37	chr20	49208922	49208922	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgactgcaccagccaggcGagcgctggccgccctgcaca	7	4	12	18	3	0	1	0	1	0	0	0	2	0	1	5	2	4	3	5	2	0	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:49208922G>T	uc002xvm.2	-	19	2842	c.2524C>A	c.(2524-2526)CGC>AGC	p.R842S	FAM65C_uc010zyt.1_Missense_Mutation_p.R846S	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	842										ovary(2)	2						CCAGCCAGGCGAGCGCTGGCC	0.652													12	34					3.35478e-16	3.49406e-16	1	0	T	49208922	T	T	49208922	3	4	303	1	0	0	0	0	1	0	0	0	5633	1058	37	3	332	3	FAM65C	20	49208922	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	4620884	49208922	13816598	724	56251											
ATP9A	10079	broad.mit.edu	37	chr20	50292704	50292704	+	Silent	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	tttgaggtattcatgacactCcggagttctctgccagtgta	8	14	10	9	1	2	2	1	2	1	0	4	3	3	3	2	2	1	3	2	2	2	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:50292704C>G	uc002xwg.1	-	10	843	c.843G>C	c.(841-843)CGG>CGC	p.R281R	ATP9A_uc010gih.1_Silent_p.R145R|ATP9A_uc002xwf.1_5'UTR	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	281	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TCATGACACTCCGGAGTTCTC	0.423													7	25					0	0	0	0	G	50292704	G	G	50292704	2	3	303	1	0	0	0	0	0	0	0	1	1200	842	30	2		2	ATP9A	20	50292704	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1083782	50292704	12732816	725	56252											
RPS21	6227	broad.mit.edu	37	chr20	60963404	60963404	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctccgattggccaaggccGatggcatcgtctcaaagtaa	10	10	10	11	3	2	0	1	0	2	0	5	2	2	0	3	3	0	2	3	3	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:60963404G>A	uc002ycr.2	+	5	316	c.226G>A	c.(226-228)GAT>AAT	p.D76N	RPS21_uc002ycs.2_Missense_Mutation_p.D76N|RPS21_uc002yct.2_3'UTR|RPS21_uc002ycu.2_Missense_Mutation_p.D76N	NM_001024	NP_001015	P63220	RS21_HUMAN	ribosomal protein S21	76					endocrine pancreas development|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein N-terminus binding|structural constituent of ribosome				0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			GGCCAAGGCCGATGGCATCGT	0.493													5	15					0	0	0	0	A	60963404	A	A	60963404	3	1	303	1	0	0	0	0	1	0	0	0	13698	1058	37	1	240	1	RPS21	20	60963404	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10670700	60963404	2062116	726	56253											
DIDO1	11083	broad.mit.edu	37	chr20	61512069	61512069	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctgaccctgaaacgggggctGagagccccccactttctgtc	7	8	11	15	1	1	3	0	3	1	1	2	4	1	3	4	2	2	1	4	2	1	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:61512069G>A	uc002ydr.1	-	16	5503	c.5239C>T	c.(5239-5241)CAG>TAG	p.Q1747*	DIDO1_uc002yds.1_Nonsense_Mutation_p.Q1747*	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1747	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					AACGGGGGCTGAGAGCCCCCC	0.682													30	62					0	0	0	0	A	61512069	A	A	61512069	4	1	303	1	0	0	0	0	0	1	0	0	4544	1299	45	2	1487	2	DIDO1	20	61512069	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	548665	61512069	1513451	727	56254											
PRIC285	85441	broad.mit.edu	37	chr20	62200815	62200815	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	tgtagcagcaccggccggcgGccaaagtcgaagaccaccca	11	3	12	15	4	0	1	0	0	0	1	1	2	0	1	5	3	2	3	5	3	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:62200815G>C	uc002yfm.2	-	5	1666	c.774C>G	c.(772-774)GGC>GGG	p.G258G	PRIC285_uc002yfl.1_5'Flank	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	258					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CCGGCCGGCGGCCAAAGTCGA	0.667													6	9					0	0	0	0	C	62200815	C	C	62200815	2	2	303	1	0	0	0	0	0	0	0	1	12547	1190	42	4		4	PRIC285	20	62200815	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	688746	62200815	824705	728	56255											
RTEL1	51750	broad.mit.edu	37	chr20	62321792	62321792	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagcctgaagcagaggtcctCaggtgcggacgggcagcgct	8	5	16	12	3	1	2	1	1	0	1	2	3	2	3	2	4	4	3	2	4	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:62321792C>T	uc002yfu.1	+	26	2754	c.2411C>T	c.(2410-2412)TCA>TTA	p.S804L	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.S804L|RTEL1_uc011abd.1_Missense_Mutation_p.S828L|RTEL1_uc011abe.1_Missense_Mutation_p.S581L|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_Missense_Mutation_p.S49L	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	804					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CAGAGGTCCTCAGGTGCGGAC	0.697													9	20					0	0	0	0	T	62321792	T	T	62321792	3	4	303	1	0	0	0	0	1	0	0	0	13785	838	29	2	2509	2	RTEL1	20	62321792	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	120977	62321792	703728	729	56256											
ZGPAT	84619	broad.mit.edu	37	chr20	62340463	62340463	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	taccccactcacaagtctctGaagccgtgcccgttcttcct	7	11	6	17	2	3	1	1	1	2	0	5	1	4	1	5	0	3	1	5	0	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr20:62340463G>A	uc002ygk.2	+	2	709	c.531G>A	c.(529-531)CTG>CTA	p.L177L	ARFRP1_uc002yga.2_5'Flank|ARFRP1_uc002ygc.2_5'Flank|ARFRP1_uc002ygh.3_5'Flank|ARFRP1_uc011abf.1_5'Flank|ARFRP1_uc011abg.1_5'Flank|ARFRP1_uc002yge.2_5'Flank|ARFRP1_uc002ygd.2_5'Flank|ARFRP1_uc002ygf.2_5'Flank|ARFRP1_uc002ygg.2_5'Flank|ARFRP1_uc011abh.1_5'Flank|ZGPAT_uc002ygi.2_Silent_p.L177L|ZGPAT_uc002ygj.2_Silent_p.L177L|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Silent_p.L177L|ZGPAT_uc002ygm.2_Silent_p.L177L|ZGPAT_uc002ygn.3_RNA	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	177	C3H1-type.				negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					ACAAGTCTCTGAAGCCGTGCC	0.572													41	106					0	0	0	0	A	62340463	A	A	62340463	2	1	303	1	0	0	0	0	0	0	0	1	17741	1277	45	2		2	ZGPAT	20	62340463	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	18671	62340463	685057	730	56257											
HMGN1	3150	broad.mit.edu	37	chr21	40720242	40720242	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgctgcctttttcggcttCgcttccacttttgcaggagg	3	15	11	12	2	0	0	0	0	0	0	3	1	1	1	2	3	3	5	2	3	0	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr21:40720242C>T	uc002yxo.2	-	4	306	c.102G>A	c.(100-102)GCG>GCA	p.A34A	HMGN1_uc002yxp.2_5'UTR|HMGN1_uc002yxq.2_5'UTR|HMGN1_uc002yxr.2_RNA	NM_004965	NP_004956	P05114	HMGN1_HUMAN	high-mobility group nucleosome binding domain 1	34					positive regulation of transcription elongation, DNA-dependent	chromatin|cytoplasm|nucleus	DNA binding			breast(1)	1		Prostate(19;8.69e-07)				TTTTCGGCTTCGCTTCCACTT	0.562													27	59					0	0	0	0	T	40720242	T	T	40720242	2	4	303	1	0	0	0	0	0	0	0	1	7273	871	31	1		1	HMGN1	21	40720242	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08		40720242	7409653	731	56258											
CECR2	27443	broad.mit.edu	37	chr22	17978481	17978481	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tccgtgtggagccattgggtGaagacaattctggggcacta	9	10	14	8	1	1	2	0	1	1	1	2	3	2	3	2	4	1	1	2	4	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:17978481G>A	uc010gqw.1	+	3	445	c.319G>A	c.(319-321)GAA>AAA	p.E107K	CECR2_uc010gqv.1_5'UTR|CECR2_uc002zml.2_5'UTR|CECR2_uc002zmm.1_5'UTR	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	149					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		GCCATTGGGTGAAGACAATTC	0.488													10	36					0	0	0	0	A	17978481	A	A	17978481	3	1	303	1	0	0	0	0	1	0	0	0	3221	1291	45	2	331	2	CECR2	22	17978481	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08		17978481	33326085	732	56259											
CECR2	27443	broad.mit.edu	37	chr22	17978563	17978563	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	ggtgcaaggaaaatccaatgGagaactctctttgagcaggt	13	9	12	7	0	1	2	0	1	1	1	3	4	2	3	1	4	3	2	1	4	5	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:17978563G>A	uc010gqw.1	+	3	527	c.401G>A	c.(400-402)GGA>GAA	p.G134E	CECR2_uc010gqv.1_Missense_Mutation_p.G13E|CECR2_uc002zml.2_Missense_Mutation_p.G13E|CECR2_uc002zmm.1_Missense_Mutation_p.G13E	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	176					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		AAATCCAATGGAGAACTCTCT	0.408													5	9					0	0	0	0	A	17978563	A	A	17978563	3	1	303	1	0	0	0	0	1	0	0	0	3221	1174	41	2	413	2	CECR2	22	17978563	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	82	17978563	33326003	733	56260											
P2RX6	9127	broad.mit.edu	37	chr22	21377815	21377815	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cagggtggctctgtaggcatCagagttcactgggattgtga	8	11	15	7	0	3	2	2	1	1	1	3	3	3	3	0	4	0	4	0	4	1	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:21377815C>T	uc010gsu.1	+	8	798	c.798C>T	c.(796-798)ATC>ATT	p.I266I	P2RX6_uc002ztz.2_Silent_p.I240I|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	266	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						CTGTAGGCATCAGAGTTCACT	0.602													7	13					0	0	0	0	T	21377815	T	T	21377815	2	4	303	1	0	0	0	0	0	0	0	1	11398	816	29	2		2	P2RX6	22	21377815	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	3399252	21377815	29926751	734	56261											
C22orf13	83606	broad.mit.edu	37	chr22	24939877	24939877	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttgtagccacgcagcacgatGaagtggccctggtagtcagg	9	8	14	10	2	1	1	1	1	0	0	1	2	1	1	2	3	2	4	2	3	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:24939877G>A	uc003aah.2	-	5	877	c.561C>T	c.(559-561)TTC>TTT	p.F187F	C22orf13_uc003aal.2_Silent_p.F243F|C22orf13_uc003aai.3_Silent_p.F144F|C22orf13_uc003aaj.3_Silent_p.F187F|C22orf13_uc003aak.3_Silent_p.F243F	NM_031444	NP_113632	Q96NT3	CV013_HUMAN	chromosome 22 open reading frame 13	187											0						GCAGCACGATGAAGTGGCCCT	0.617													9	24					0	0	0	0	A	24939877	A	A	24939877	2	1	303	1	0	0	0	0	0	0	0	1	2145	1281	45	2		2	C22orf13	22	24939877	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	3562062	24939877	26364689	735	56262											
KCNJ4	3761	broad.mit.edu	37	chr22	38823412	38823412	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccgatgtcatagcccacgttGaggtcccgctggtccagggg	6	8	14	13	3	1	1	1	1	0	0	3	2	3	1	4	4	1	2	4	4	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:38823412G>A	uc003avs.1	-	2	823	c.726C>T	c.(724-726)CTC>CTT	p.L242L	KCNJ4_uc003avt.1_Silent_p.L242L	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	242	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					AGCCCACGTTGAGGTCCCGCT	0.622													9	42					0	0	0	0	A	38823412	A	A	38823412	2	1	303	1	0	0	0	0	0	0	0	1	8092	1277	45	2		2	KCNJ4	22	38823412	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	13883535	38823412	12481154	736	56263											
KCNJ4	3761	broad.mit.edu	37	chr22	38823925	38823925	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cagaagaggaggccgaaaaaGagccaggagacaaggaaggc	18	0	16	7	1	0	4	0	0	0	4	0	8	0	6	2	5	1	0	2	5	5	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:38823925G>C	uc003avs.1	-	2	310	c.213C>G	c.(211-213)CTC>CTG	p.L71L	KCNJ4_uc003avt.1_Silent_p.L71L	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	71	Helical; Name=M1; (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					GGCCGAAAAAGAGCCAGGAGA	0.547													7	14					0	0	0	0	C	38823925	C	C	38823925	2	2	303	1	0	0	0	0	0	0	0	1	8092	929	33	2		2	KCNJ4	22	38823925	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	513	38823925	12480641	737	56264											
ADSL	158	broad.mit.edu	37	chr22	40750320	40750320	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	agtctacccacattaggtttCacacatttccagtaagtgat	12	13	6	10	0	2	1	1	1	1	0	3	1	3	1	2	1	1	2	2	1	3	5			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:40750320C>G	uc003ayp.3	+	4	530	c.471C>G	c.(469-471)TTC>TTG	p.F157L	ADSL_uc003ays.3_Missense_Mutation_p.F157L|ADSL_uc003ayq.3_Missense_Mutation_p.F157L|ADSL_uc003ayr.3_5'UTR|ADSL_uc003ayt.3_Missense_Mutation_p.F142L	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	157					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1						CATTAGGTTTCACACATTTCC	0.423													44	143					0	0	0	0	G	40750320	G	G	40750320	3	3	303	1	0	0	0	0	1	0	0	0	346	825	29	2	485	2	ADSL	22	40750320	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1926395	40750320	10554246	738	56265											
MCHR1	2847	broad.mit.edu	37	chr22	41075673	41075673	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ctggatggacctggaagcctCgctgctgcccactggtccca	6	8	12	15	1	0	0	0	0	0	0	2	3	1	3	4	4	3	2	4	4	1	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:41075673C>T	uc003ayz.2	+	1	492	c.224C>T	c.(223-225)TCG>TTG	p.S75L	MCHR1_uc003aza.2_Intron	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	75	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0						CTGGAAGCCTCGCTGCTGCCC	0.677													40	93					0	0	0	0	T	41075673	T	T	41075673	3	4	303	1	0	0	0	0	1	0	0	0	9435	893	31	1	226	1	MCHR1	22	41075673	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	325353	41075673	10228893	739	56266											
SERHL2	253190	broad.mit.edu	37	chr22	42967208	42967211	+	Splice_Site	DEL	AAGT	-	-																															aggcccatgtcctgttgatcAagtaagtctggacccatccc																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:42967208_42967211delAAGT	uc003bcr.2	+	10	833	c.731_splice	c.e10+1	p.K244_splice	SERHL_uc011apm.1_Intron|SERHL2_uc011apn.1_Frame_Shift_Del_p.K261fs|SERHL2_uc010gyz.2_Splice_Site_p.K180_splice|SERHL2_uc010gyy.2_RNA|SERHL2_uc011apo.1_RNA|RRP7B_uc003bcs.2_Intron	NM_014509	NP_055324	Q9H4I8	SEHL2_HUMAN	serine hydrolase-like 2							perinuclear region of cytoplasm|peroxisome	hydrolase activity				0						CCTGTTGATCAAGTAAGTCTGGAC	0.574													---	---	---								-	42967211	-	-	42967208	8	5	303	1	0	1	0	1	0	0	1	0	14143	144	5	0	768	0	SERHL2	22	42967208	Splice_Site	DEL	AAGT	TCGA-HL-7533-01A-11D-2229-08	1891535	42967208	8337358	740	56267											
ARFGAP3	26286	broad.mit.edu	37	chr22	43230280	43230280	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	gtgagaggcaaaaaaatcttCctcctttggtggaggggaca	12	9	13	7	0	1	1	0	1	1	1	3	4	3	3	2	5	0	1	2	5	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:43230280C>T	uc003bdd.2	-	5	665	c.445G>A	c.(445-447)GAA>AAA	p.E149K	ARFGAP3_uc010gzf.2_Missense_Mutation_p.E105K|ARFGAP3_uc011apu.1_Intron	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	149					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						AAAAAATCTTCCTCCTTTGGT	0.413													46	105					0	0	0	0	T	43230280	T	T	43230280	3	4	303	1	0	0	0	0	1	0	0	0	851	864	30	2	1153	2	ARFGAP3	22	43230280	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	263072	43230280	8074286	741	56268											
ALG12	79087	broad.mit.edu	37	chr22	50298025	50298025	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tggtgcagcctctgcattgcGacgccacctgggtagttgaa	7	10	13	11	2	1	1	0	1	1	0	1	2	1	1	3	2	4	4	3	2	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:50298025G>A	uc003biy.2	-	8	1396	c.1122C>T	c.(1120-1122)GTC>GTT	p.V374V		NM_024105	NP_077010	Q9BV10	ALG12_HUMAN	alpha-1,6-mannosyltransferase ALG12	374					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane					0		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		BRCA - Breast invasive adenocarcinoma(115;0.199)|LUAD - Lung adenocarcinoma(64;0.247)		TCTGCATTGCGACGCCACCTG	0.642													12	25					0	0	0	0	A	50298025	A	A	50298025	2	1	303	1	0	0	0	0	0	0	0	1	514	1045	37	1		1	ALG12	22	50298025	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	7067745	50298025	1006541	742	56269											
MOV10L1	54456	broad.mit.edu	37	chr22	50591518	50591518	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cggtcccacgaggccctgctGatgctgccctcacggctgtt	4	9	12	16	3	1	1	1	1	0	0	2	2	2	1	3	3	3	4	3	3	0	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:50591518G>A	uc003bjj.2	+	22	3020	c.2937G>A	c.(2935-2937)CTG>CTA	p.L979L	MOV10L1_uc003bjk.3_Silent_p.L979L|MOV10L1_uc011arp.1_Silent_p.L959L|MOV10L1_uc003bjl.2_Silent_p.L106L|MOV10L1_uc003bjm.1_Silent_p.L22L	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	979					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		AGGCCCTGCTGATGCTGCCCT	0.592													35	122					0	0	0	0	A	50591518	A	A	50591518	2	1	303	1	0	0	0	0	0	0	0	1	9772	1277	45	2		2	MOV10L1	22	50591518	Silent	SNP	G	TCGA-HL-7533-01A-11D-2229-08	293493	50591518	713048	743	56270											
PLXNB2	23654	broad.mit.edu	37	chr22	50728135	50728135	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tctctgctgaagacagcataTagcaccctgccagagccagg	11	7	10	13	0	1	3	0	1	1	2	2	3	1	3	3	1	5	3	3	1	3	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chr22:50728135T>C	uc003bkv.3	-	3	985	c.879A>G	c.(877-879)CTA>CTG	p.L293L		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	293	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGACAGCATATAGCACCCTGC	0.682													21	44					0	0	0	0	C	50728135	C	C	50728135	2	2	303	1	0	0	0	0	0	0	0	1	12179	1393	49	5		5	PLXNB2	22	50728135	Silent	SNP	T	TCGA-HL-7533-01A-11D-2229-08	136617	50728135	576431	744	56271											
PPP2R3B	28227	broad.mit.edu	37	chrX	299394	299394	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	caccaggatgtcgtactcctCggccgcgtacttctcccagt	6	10	9	16	4	1	0	0	0	1	0	5	1	2	1	4	2	2	2	4	2	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:299394C>T	uc004cpg.2	-	12	1723	c.1522G>A	c.(1522-1524)GAG>AAG	p.E508K	PPP2R3B_uc004cpf.2_Missense_Mutation_p.E109K	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	508					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCGTACTCCTCGGCCGCGTAC	0.433													13	30					0	0	0	0	T	299394	T	T	299394	3	4	303	1	0	0	0	0	1	0	0	0	12449	893	31	1	213	1	PPP2R3B	23	299394	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08		299394	154971166	745	56272											
DMD	1756	broad.mit.edu	37	chrX	32404565	32404565	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	acttcagacttcacttcactCagacttttatacaagttcta	12	15	3	11	0	5	2	4	0	1	2	5	2	5	2	0	0	1	1	0	0	4	8			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:32404565C>G	uc004dda.1	-	33	4780	c.4536G>C	c.(4534-4536)CTG>CTC	p.L1512L	DMD_uc004dcw.2_Silent_p.L168L|DMD_uc004dcx.2_Silent_p.L171L|DMD_uc004dcz.2_Silent_p.L1389L|DMD_uc004dcy.1_Silent_p.L1508L|DMD_uc004ddb.1_Silent_p.L1504L|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1512	Spectrin 10.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCACTTCACTCAGACTTTTAT	0.303													8	11					0	0	0	0	G	32404565	G	G	32404565	2	3	303	1	0	0	0	0	0	0	0	1	4602	813	29	2		2	DMD	23	32404565	Silent	SNP	C	TCGA-HL-7533-01A-11D-2229-08	32105171	32404565	122865995	746	56273											
USP9X	8239	broad.mit.edu	37	chrX	41027443	41027443	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatgtgacagtgattatcatGaggaaagaacaattctccct	15	11	8	7	0	2	4	1	3	1	1	3	5	2	5	1	1	1	0	1	1	5	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:41027443G>A	uc004dfb.2	+	18	3241	c.2608G>A	c.(2608-2610)GAG>AAG	p.E870K	USP9X_uc004dfc.2_Missense_Mutation_p.E870K	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	870					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TGATTATCATGAGGAAAGAAC	0.333													12	15					0	0	0	0	A	41027443	A	A	41027443	3	1	303	1	0	0	0	0	1	0	0	0	17158	1291	45	2	2674	2	USP9X	23	41027443	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	8622878	41027443	114243117	747	56274											
DDX3X	1654	broad.mit.edu	37	chrX	41200778	41200778	+	Frame_Shift_Del	DEL	G	-	-																															cagggtggagttctagcaaaGataaggatgcgtatagcagt																										TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:41200778delG	uc004dfe.2	+	4	1048	c.193delG	c.(193-195)GATfs	p.D65fs	DDX3X_uc010nhf.1_Frame_Shift_Del_p.D49fs|DDX3X_uc004dff.2_Frame_Shift_Del_p.D65fs|DDX3X_uc011mkq.1_Frame_Shift_Del_p.D49fs|DDX3X_uc011mkr.1_Frame_Shift_Del_p.D65fs|DDX3X_uc011mks.1_Frame_Shift_Del_p.D65fs|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	65					interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						TTCTAGCAAAGATAAGGATGC	0.368										HNSCC(61;0.18)			---	---	---								-	41200778	-	-	41200778	7	5	303	1	0	1	0	1	0	0	0	0	4375	942	33	0	207	0	DDX3X	23	41200778	Frame_Shift_Del	DEL	G	TCGA-HL-7533-01A-11D-2229-08	173335	41200778	114069782	748	56275											
GLOD5	392465	broad.mit.edu	37	chrX	48629496	48629496	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggaaatgatccagcacctcAaggtgagtgggacttctctt	11	10	11	9	0	2	2	1	2	1	0	4	4	3	4	2	3	1	1	2	3	2	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:48629496A>G	uc011mmh.1	+	3	396	c.355A>G	c.(355-357)AAG>GAG	p.K119E		NM_001080489	NP_001073958			glyoxalase domain containing 5												0						CCAGCACCTCAAGGTGAGTGG	0.478													4	11					0	0	0	0	G	48629496	G	G	48629496	3	3	303	1	0	0	0	0	1	0	0	0	6488	131	5	5	365	5	GLOD5	23	48629496	Missense_Mutation	SNP	A	TCGA-HL-7533-01A-11D-2229-08	7428718	48629496	106641064	749	56276											
PFKFB1	5207	broad.mit.edu	37	chrX	54978429	54978429	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtcggcaaaggtagatggagCgaggtgtgacatggatattc	11	9	16	5	2	0	2	0	1	0	1	2	5	0	4	0	5	1	2	0	5	3	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:54978429C>T	uc004dty.1	-	8	826	c.755G>A	c.(754-756)CGC>CAC	p.R252H	PFKFB1_uc010nkd.1_Intron|PFKFB1_uc011mol.1_Missense_Mutation_p.R187H	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	252	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						GTAGATGGAGCGAGGTGTGAC	0.557													5	13					0	0	0	0	T	54978429	T	T	54978429	3	4	303	1	0	0	0	0	1	0	0	0	11815	768	27	1	688	1	PFKFB1	23	54978429	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	6348933	54978429	100292131	750	56277											
MED12	9968	broad.mit.edu	37	chrX	70348164	70348164	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	agggtgaatgacatcgcaatCctgtgtgcagagctgaccgg	10	8	14	9	2	0	4	0	3	0	1	2	4	1	4	2	2	2	3	2	2	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:70348164C>G	uc004dyy.2	+	23	3427	c.3228C>G	c.(3226-3228)ATC>ATG	p.I1076M	MED12_uc011mpq.1_Missense_Mutation_p.I1076M|MED12_uc004dyz.2_Missense_Mutation_p.I1076M|MED12_uc004dza.2_Missense_Mutation_p.I923M|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1076					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					ACATCGCAATCCTGTGTGCAG	0.493													9	30					0	0	0	0	G	70348164	G	G	70348164	3	3	303	1	0	0	0	0	1	0	0	0	9481	845	30	2	3318	2	MED12	23	70348164	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	15369735	70348164	84922396	751	56278											
TAF1	6872	broad.mit.edu	37	chrX	70644011	70644011	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	1	0	0	0	0	cttttcatcacagaacatctCcaagcacaagtatcagagtc	14	10	5	12	0	4	2	3	0	1	2	6	2	4	2	1	0	2	2	1	0	4	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:70644011C>G	uc004dzu.3	+	32	4724	c.4673C>G	c.(4672-4674)TCC>TGC	p.S1558C	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.S1579C|TAF1_uc004dzv.3_Missense_Mutation_p.S732C|TAF1_uc010nld.1_RNA|TAF1_uc010nle.1_RNA|TAF1_uc010nlf.1_5'UTR|TAF1_uc004dzx.2_RNA|TAF1_uc004dzy.2_RNA|TAF1_uc004dzw.1_RNA	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1558	Interaction with ASF1A and ASF1B.|Bromo 2.|Protein kinase 2.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				CAGAACATCTCCAAGCACAAG	0.393													23	17					0	0	0	0	G	70644011	G	G	70644011	3	3	303	1	0	0	0	0	1	0	0	0	15579	855	30	2	4862	2	TAF1	23	70644011	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	295847	70644011	84626549	752	56279											
SERPINA7	6906	broad.mit.edu	37	chrX	105280663	105280663	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atgaagagggcatttcctatCtgcaattccagttccttctt	9	15	7	10	0	2	2	0	1	2	1	5	2	5	2	3	1	1	3	3	1	3	6			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:105280663C>G	uc004eme.1	-	1	403	c.387G>C	c.(385-387)CAG>CAC	p.Q129H	SERPINA7_uc010npd.2_Missense_Mutation_p.Q129H|SERPINA7_uc010npe.1_Missense_Mutation_p.Q129H	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	129					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	CATTTCCTATCTGCAATTCCA	0.448													35	37					0	0	0	0	G	105280663	G	G	105280663	3	3	303	1	0	0	0	0	1	0	0	0	14159	912	32	2	876	2	SERPINA7	23	105280663	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	34636652	105280663	49989897	753	56280											
RGAG1	57529	broad.mit.edu	37	chrX	109695755	109695755	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gaaaatgacaaccacagcttCtgaagcaatgcccacactgc	15	6	7	13	0	1	2	0	2	1	0	1	3	1	2	2	0	5	2	2	0	5	1	rs146389599		TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:109695755C>T	uc004eor.1	+	3	2156	c.1910C>T	c.(1909-1911)TCT>TTT	p.S637F	RGAG1_uc011msr.1_Missense_Mutation_p.S637F	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	637										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						ACCACAGCTTCTGAAGCAATG	0.507													19	18					0	0	0	0	T	109695755	T	T	109695755	3	4	303	1	0	0	0	0	1	0	0	0	13339	913	32	2	1912	2	RGAG1	23	109695755	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	4415092	109695755	45574805	754	56281											
THOC2	57187	broad.mit.edu	37	chrX	122778706	122778706	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	attgcagtccatcaaagaaaGagatggaagtagtacctggt	15	9	11	6	0	1	2	1	0	0	2	2	4	2	3	2	2	2	3	2	2	5	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:122778706G>C	uc004etu.2	-	14	1515	c.1483C>G	c.(1483-1485)CTT>GTT	p.L495V	THOC2_uc011muh.1_Missense_Mutation_p.L416V|THOC2_uc011mui.1_Missense_Mutation_p.L380V	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	495					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						ATCAAAGAAAGAGATGGAAGT	0.333													20	17					0	0	0	0	C	122778706	C	C	122778706	3	2	303	1	0	0	0	0	1	0	0	0	15931	942	33	2	3398	2	THOC2	23	122778706	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	13082951	122778706	32491854	755	56282											
FAM127B	26071	broad.mit.edu	37	chrX	134185808	134185808	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	tctcccggcctagaagtcctCgtcctcctcccatccaaaga	8	9	6	18	2	1	2	0	0	1	2	8	2	6	2	7	1	0	0	7	1	3	1			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:134185808C>G	uc004eyf.2	-	1	414	c.331G>C	c.(331-333)GAG>CAG	p.E111Q	FAM127B_uc004eyg.3_Intron	NM_001078172	NP_001071640	Q9BWD3	F127B_HUMAN	family with sequence similarity 127, member B	111											0	Acute lymphoblastic leukemia(192;0.000127)					TAGAAGTCCTCGTCCTCCTCC	0.647													8	10					0	0	0	0	G	134185808	G	G	134185808	3	3	303	1	0	0	0	0	1	0	0	0	5460	893	31	3	78	3	FAM127B	23	134185808	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	11407102	134185808	21084752	756	56283											
FAM127B	26071	broad.mit.edu	37	chrX	134185958	134185958	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gaacgtcaccttcagggcgtCgttggagaacgtgttctcgt	7	11	13	10	5	3	1	2	0	1	1	5	3	3	1	1	2	2	2	1	2	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:134185958C>G	uc004eyf.2	-	1	264	c.181G>C	c.(181-183)GAC>CAC	p.D61H	FAM127B_uc004eyg.3_Missense_Mutation_p.D61H	NM_001078172	NP_001071640	Q9BWD3	F127B_HUMAN	family with sequence similarity 127, member B	61											0	Acute lymphoblastic leukemia(192;0.000127)					TTCAGGGCGTCGTTGGAGAAC	0.587													12	27					0	0	0	0	G	134185958	G	G	134185958	3	3	303	1	0	0	0	0	1	0	0	0	5460	884	31	3	228	3	FAM127B	23	134185958	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	150	134185958	21084602	757	56284											
MAGEC3	139081	broad.mit.edu	37	chrX	140969550	140969550	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agggcaactgtgcatctgagGaggtcatctgggaagtgctg	9	9	16	7	0	3	1	1	1	2	0	3	3	3	3	0	4	3	3	0	4	2	0			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:140969550G>A	uc011mwp.1	+	4	877	c.877G>A	c.(877-879)GAG>AAG	p.E293K		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	293	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGCATCTGAGGAGGTCATCTG	0.522													61	69					0	0	0	0	A	140969550	A	A	140969550	3	1	303	1	0	0	0	0	1	0	0	0	9235	1175	41	2	891	2	MAGEC3	23	140969550	Missense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	6783592	140969550	14301010	758	56285											
GABRA3	2556	broad.mit.edu	37	chrX	151336902	151336902	+	Nonsense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aagcaatgattgttggggttGaggaggcactgggagcagcg	10	8	18	5	1	0	2	0	2	0	0	0	4	0	4	0	5	3	5	0	5	2	3			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:151336902G>C	uc010ntk.1	-	10	1517	c.1277C>G	c.(1276-1278)TCA>TGA	p.S426*		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	426	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGTTGGGGTTGAGGAGGCACT	0.537													54	74					0	0	0	0	C	151336902	C	C	151336902	4	2	303	1	0	0	0	0	0	1	0	0	6196	1294	45	2	205	2	GABRA3	23	151336902	Nonsense_Mutation	SNP	G	TCGA-HL-7533-01A-11D-2229-08	10367352	151336902	3933658	759	56286											
ATP2B3	492	broad.mit.edu	37	chrX	152814277	152814277	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ctgtcccagagggcctgcctCttgctgtcaccatctcctta	5	12	8	16	0	3	1	1	0	2	1	5	1	4	1	5	1	2	1	5	1	1	2			TCGA-HL-7533-01A-11D-2229-08	TCGA-HL-7533-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	fbf8f4a8-be9e-4713-884d-c80ef662d622	db3a90aa-d1c0-4e75-80b4-c1058f469b42	g.chrX:152814277C>G	uc004fht.1	+	8	1429	c.1303C>G	c.(1303-1305)CTT>GTT	p.L435V	ATP2B3_uc004fhs.1_Missense_Mutation_p.L435V	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	435	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGCCTGCCTCTTGCTGTCAC	0.483													19	19					0	0	0	0	G	152814277	G	G	152814277	3	3	303	1	0	0	0	0	1	0	0	0	1143	913	32	2	1333	2	ATP2B3	23	152814277	Missense_Mutation	SNP	C	TCGA-HL-7533-01A-11D-2229-08	1477375	152814277	2456283	760	56287											
PAX7	5081	broad.mit.edu	37	chr1	19018401	19018401	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctacccagacatatacacccGcgaggagctggcgcagagga	12	4	12	13	3	0	2	0	0	0	2	0	5	0	4	2	3	3	2	2	3	3	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr1:19018401G>A	uc001bay.2	+	5	1338	c.740G>A	c.(739-741)CGC>CAC	p.R247H	PAX7_uc001baz.2_Missense_Mutation_p.R245H|PAX7_uc010oct.1_Missense_Mutation_p.R247H	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	247	Homeobox.				anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		ATATACACCCGCGAGGAGCTG	0.607			T	FOXO1A	alveolar rhabdomyosarcoma								8	16					0	0	0	0	A	19018401	A	A	19018401	3	1	304	1	0	0	0	0	1	0	0	0	11538	1087	38	1	758	1	PAX7	1	19018401	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08		19018401	230232220	1	56288											
HSPG2	3339	broad.mit.edu	37	chr1	22191363	22191363	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gacagaccgatgtagcctggCgggcagcggcactcctccac	8	5	13	15	3	0	1	0	0	0	1	2	3	2	1	4	3	2	3	4	3	1	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr1:22191363C>T	uc001bfj.2	-	36	4639	c.4599G>A	c.(4597-4599)CCG>CCA	p.P1533P	HSPG2_uc009vqd.2_Silent_p.P1534P	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	1533	Laminin EGF-like 9; second part.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGTAGCCTGGCGGGCAGCGGC	0.687													4	11					0	0	0	0	T	22191363	T	T	22191363	2	4	304	1	0	0	0	0	0	0	0	1	7469	755	27	1		1	HSPG2	1	22191363	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	3172962	22191363	227059258	2	56289											
HSPG2	3339	broad.mit.edu	37	chr1	22205082	22205082	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccctcacctctcacagcggCggccagtgtagcctggggca	6	7	12	16	2	2	0	2	0	1	0	4	0	3	0	4	4	2	2	4	4	1	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr1:22205082C>A	uc001bfj.2	-	19	2586	c.2546G>T	c.(2545-2547)CGC>CTC	p.R849L	HSPG2_uc009vqd.2_Missense_Mutation_p.R850L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	849	Laminin EGF-like 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding	p.R849R(1)		ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CTCACAGCGGCGGCCAGTGTA	0.632													8	31					0.000274275	0.00029113	1	0	A	22205082	A	A	22205082	3	1	304	1	0	0	0	0	1	0	0	0	7469	768	27	3	10945	3	HSPG2	1	22205082	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	13719	22205082	227045539	3	56290											
SLC9A1	6548	broad.mit.edu	37	chr1	27436232	27436232	+	Frame_Shift_Del	DEL	C	-	-																															gtccacgatgcccacgtgttCgtagttggcaaactcctcaa																										TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr1:27436232delC	uc001bnm.2	-	3	1476	c.850delG	c.(850-852)GAAfs	p.E284fs	SLC9A1_uc010ofk.1_5'UTR|SLC9A1_uc001bnn.2_Frame_Shift_Del_p.E284fs	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	284	Extracellular (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	CCCACGTGTTCGTAGTTGGCA	0.642													---	---	---								-	27436232	-	-	27436232	7	5	304	1	0	1	0	1	0	0	0	0	14773	893	31	0	1637	0	SLC9A1	1	27436232	Frame_Shift_Del	DEL	C	TCGA-IQ-7630-01A-11D-2078-08	5231150	27436232	221814389	4	56291											
TAL1	6886	broad.mit.edu	37	chr1	47689752	47689752	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgaacatagggaaggcatcCggctccccaaagaacccgct	12	5	11	13	2	0	2	0	1	0	1	2	3	2	3	4	3	2	3	4	3	5	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr1:47689752C>T	uc001cqx.2	-	3	1042	c.465G>A	c.(463-465)CCG>CCA	p.P155P	TAL1_uc009vyq.2_5'UTR|TAL1_uc001cqy.2_Silent_p.P155P|TAL1_uc001cra.1_RNA|TAL1_uc001cqz.1_RNA	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	155					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1						GGAAGGCATCCGGCTCCCCAA	0.562			T	TRD@|SIL	lymphoblastic leukemia/biphasic								23	66					0	0	0	0	T	47689752	T	T	47689752	2	4	304	1	0	0	0	0	0	0	0	1	15607	639	23	1		1	TAL1	1	47689752	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	20253520	47689752	201560869	5	56292											
OMA1	115209	broad.mit.edu	37	chr1	59002204	59002204	+	Nonsense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcttcatattccagttccGataaaagtctgaactgttct	10	15	6	10	1	3	1	1	1	2	0	5	2	5	1	2	0	2	3	2	0	4	6			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr1:59002204G>T	uc001cyy.2	-	3	798	c.710C>A	c.(709-711)TCG>TAG	p.S237*	DAB1_uc001cyt.1_Intron|OMA1_uc001cyx.1_Nonsense_Mutation_p.S237*|OMA1_uc009vzz.2_Nonsense_Mutation_p.S237*	NM_145243	NP_660286	Q96E52	OMA1_HUMAN	OMA1 homolog, zinc metallopeptidase precursor	237					proteolysis	integral to membrane|mitochondrial membrane	metal ion binding|metalloendopeptidase activity			large_intestine(1)	1	all_cancers(7;6.54e-05)					TTCCAGTTCCGATAAAAGTCT	0.343													12	30					5.16669e-11	5.77453e-11	1	0	T	59002204	T	T	59002204	4	4	304	1	0	0	0	0	0	1	0	0	10918	1059	37	3	892	3	OMA1	1	59002204	Nonsense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	11312452	59002204	190248417	6	56293											
FCRL5	83416	broad.mit.edu	37	chr1	157509002	157509002	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cactcctcctgcagagttggCcgacctacgctccagggcag	7	7	11	16	2	0	1	0	0	0	1	3	2	3	1	5	2	2	4	5	2	1	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr1:157509002C>T	uc001fqu.2	-	7	1434	c.1276G>A	c.(1276-1278)GCC>ACC	p.A426T	FCRL5_uc009wsm.2_Missense_Mutation_p.A426T|FCRL5_uc010phv.1_Missense_Mutation_p.A426T|FCRL5_uc010phw.1_Missense_Mutation_p.A341T|FCRL5_uc001fqv.1_Missense_Mutation_p.A426T|FCRL5_uc010phx.1_Missense_Mutation_p.A177T	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	426	Extracellular (Potential).|Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GCAGAGTTGGCCGACCTACGC	0.572													3	41					0	0	0	0	T	157509002	T	T	157509002	3	4	304	1	0	0	0	0	1	0	0	0	5830	739	26	4	1701	4	FCRL5	1	157509002	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	98506798	157509002	91741619	7	56294											
LHX9	56956	broad.mit.edu	37	chr1	197889131	197889131	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccgctcagcccggagaagccCgccctgtgcgccggctgcgg	4	4	15	18	6	1	1	1	0	0	1	1	2	1	1	5	3	4	2	5	3	1	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr1:197889131C>T	uc001guk.1	+	2	641	c.204C>T	c.(202-204)CCC>CCT	p.P68P	LHX9_uc001gui.1_Silent_p.P59P|LHX9_uc001guj.1_Silent_p.P74P	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	68					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						CGGAGAAGCCCGCCCTGTGCG	0.642													30	81					0	0	0	0	T	197889131	T	T	197889131	2	4	304	1	0	0	0	0	0	0	0	1	8818	639	23	1		1	LHX9	1	197889131	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	40380129	197889131	51361490	8	56295											
NR5A2	2494	broad.mit.edu	37	chr1	200017721	200017721	+	Silent	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tatatggatagttaccagacGagctctccagcaagcatccc	12	9	8	12	1	1	1	0	0	1	1	3	3	2	2	3	1	4	4	3	1	5	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr1:200017721G>T	uc001gvb.2	+	5	1091	c.885G>T	c.(883-885)ACG>ACT	p.T295T	NR5A2_uc001gvc.2_Silent_p.T249T|NR5A2_uc009wzh.2_Silent_p.T255T|NR5A2_uc010pph.1_Silent_p.T223T	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	295					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					GTTACCAGACGAGCTCTCCAG	0.498													24	52					1.10923e-09	1.22531e-09	1	0	T	200017721	T	T	200017721	2	4	304	1	0	0	0	0	0	0	0	1	10690	1045	37	3		3	NR5A2	1	200017721	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	2128590	200017721	49232900	9	56296											
FAM71A	149647	broad.mit.edu	37	chr1	212798505	212798505	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	cacgaccggccaccggctgcGaagagtatgctggacatggc	9	5	14	13	4	0	1	0	0	0	1	0	4	0	2	3	4	2	3	3	4	2	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr1:212798505G>A	uc001hjk.2	+	1	690	c.286G>A	c.(286-288)GAA>AAA	p.E96K	uc010pth.1_Intron	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	96										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CACCGGCTGCGAAGAGTATGC	0.572													5	46					0	0	0	0	A	212798505	A	A	212798505	3	1	304	1	0	0	0	0	1	0	0	0	5639	1059	37	1	288	1	FAM71A	1	212798505	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	12780784	212798505	36452116	10	56297											
SNTG2	54221	broad.mit.edu	37	chr2	1271203	1271203	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gtcttcaagattttgactttGaggaccagaggccctattgc	9	13	10	9	0	2	4	1	2	1	2	2	5	2	5	2	2	1	0	2	2	2	6			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:1271203G>C	uc002qwq.2	+	14	1272	c.1144G>C	c.(1144-1146)GAG>CAG	p.E382Q	SNTG2_uc010ewi.2_Missense_Mutation_p.E255Q	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	382	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		TTTTGACTTTGAGGACCAGAG	0.522													9	12					0	0	0	0	C	1271203	C	C	1271203	3	2	304	1	0	0	0	0	1	0	0	0	14939	1291	45	2	1198	2	SNTG2	2	1271203	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08		1271203	241928170	11	56298											
ADCY3	109	broad.mit.edu	37	chr2	25054533	25054533	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tagaaaagtgcctcttacccGgggaaagatggcagccaggg	12	6	14	9	1	1	2	0	0	1	2	1	3	1	3	3	4	3	1	3	4	5	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:25054533G>A	uc002rfs.3	-	11	2252	c.2053C>T	c.(2053-2055)CGG>TGG	p.R685W	ADCY3_uc002rfr.3_Missense_Mutation_p.R318W|ADCY3_uc010ykm.1_Missense_Mutation_p.R685W	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	685					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					CCTCTTACCCGGGGAAAGATG	0.498													5	24					0	0	0	0	A	25054533	A	A	25054533	3	1	304	1	0	0	0	0	1	0	0	0	295	1115	39	1	1425	1	ADCY3	2	25054533	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	23783330	25054533	218144840	12	56299											
TTC27	55622	broad.mit.edu	37	chr2	33036234	33036234	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatggagaaatctggaggctGtatgcccacgtatatggaaa	13	9	13	6	1	1	1	0	0	1	1	1	5	1	3	1	4	1	3	1	4	5	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:33036234G>A	uc002rom.2	+	17	2373	c.2142G>A	c.(2140-2142)CTG>CTA	p.L714L	TTC27_uc010ymx.1_Silent_p.L664L|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	714	HAT 3.						protein binding			central_nervous_system(1)	1						TCTGGAGGCTGTATGCCCACG	0.453													8	32					0	0	0	0	A	33036234	A	A	33036234	2	1	304	1	0	0	0	0	0	0	0	1	16763	1364	48	4		4	TTC27	2	33036234	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	7981701	33036234	210163139	13	56300											
ZNF638	27332	broad.mit.edu	37	chr2	71591185	71591185	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctcaagtcacagattccgtcGgtctcgaagcccaatgcatt	10	10	8	13	3	3	1	2	0	1	1	6	2	4	1	2	1	2	1	2	1	3	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:71591185G>T	uc002shx.2	+	5	1839	c.1520G>T	c.(1519-1521)CGG>CTG	p.R507L	ZNF638_uc010fec.2_Missense_Mutation_p.R613L|ZNF638_uc010yqw.1_Missense_Mutation_p.R86L|ZNF638_uc002shw.2_Missense_Mutation_p.R507L|ZNF638_uc002shy.2_Missense_Mutation_p.R507L|ZNF638_uc002shz.2_Missense_Mutation_p.R507L|ZNF638_uc002sia.2_Missense_Mutation_p.R507L|ZNF638_uc002sib.1_Missense_Mutation_p.R507L|ZNF638_uc010fed.2_5'Flank	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	507	Arg-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						AGATTCCGTCGGTCTCGAAGC	0.453													24	45					4.26978e-12	4.82891e-12	1	0	T	71591185	T	T	71591185	3	4	304	1	0	0	0	0	1	0	0	0	18122	1116	39	3	1534	3	ZNF638	2	71591185	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	38554951	71591185	171608188	14	56301											
DYSF	8291	broad.mit.edu	37	chr2	71755438	71755438	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctcttcccagtggacgatgcCgtgatggacaacgtgaaaca	11	8	11	11	3	1	2	0	2	1	0	2	5	2	4	2	2	3	0	2	2	2	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:71755438C>T	uc002sie.2	+	13	1567	c.1191C>T	c.(1189-1191)GCC>GCT	p.A397A	DYSF_uc010feg.2_Silent_p.A428A|DYSF_uc010feh.2_Silent_p.A397A|DYSF_uc002sig.3_Silent_p.A397A|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.A397A|DYSF_uc010fef.2_Silent_p.A428A|DYSF_uc010fei.2_Silent_p.A428A|DYSF_uc010fek.2_Silent_p.A429A|DYSF_uc010fej.2_Silent_p.A398A|DYSF_uc010fel.2_Silent_p.A398A|DYSF_uc010feo.2_Silent_p.A429A|DYSF_uc010fem.2_Silent_p.A398A|DYSF_uc010fen.2_Silent_p.A429A|DYSF_uc002sif.2_Silent_p.A398A	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	397	Cytoplasmic (Potential).|C2 3.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TGGACGATGCCGTGATGGACA	0.542													7	16					0	0	0	0	T	71755438	T	T	71755438	2	4	304	1	0	0	0	0	0	0	0	1	4881	639	23	1		1	DYSF	2	71755438	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	164253	71755438	171443935	15	56302											
CNGA3	1261	broad.mit.edu	37	chr2	99013652	99013652	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	agccaggtgaagggtggtggGgacaagcccctggctgatgg	8	6	19	8	0	0	2	0	2	0	0	0	3	0	3	3	7	2	1	3	7	2	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:99013652G>T	uc002syt.2	+	8	2436	c.2019G>T	c.(2017-2019)GGG>GGT	p.G673G	CNGA3_uc002syu.2_Silent_p.G655G|CNGA3_uc010fij.2_Silent_p.G677G	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	673					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						AGGGTGGTGGGGACAAGCCCC	0.557													9	42					1.58986e-06	1.71633e-06	1	0	T	99013652	T	T	99013652	2	4	304	1	0	0	0	0	0	0	0	1	3613	1219	43	4		4	CNGA3	2	99013652	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	27258214	99013652	144185721	16	56303											
TMEM37	140738	broad.mit.edu	37	chr2	120194723	120194723	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcatgggcctggtacgcagcGtgggcgccttggccgtggtg	3	8	19	11	4	0	0	0	0	0	0	0	0	0	0	3	5	2	3	3	5	1	2	rs148211959	byFrequency	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:120194723G>A	uc002tly.2	+	2	314	c.280G>A	c.(280-282)GTG>ATG	p.V94M		NM_183240	NP_899063	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	94						integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)	1						GGTACGCAGCGTGGGCGCCTT	0.637													21	68					0	0	0	0	A	120194723	A	A	120194723	3	1	304	1	0	0	0	0	1	0	0	0	16224	1145	40	1	286	1	TMEM37	2	120194723	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	21181071	120194723	123004650	17	56304											
MYO7B	4648	broad.mit.edu	37	chr2	128384586	128384586	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcaagtcacaccactggccGtgcgagagcaggtggtggac	10	5	15	11	2	1	1	1	0	0	1	1	3	1	2	2	4	3	2	2	4	1	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:128384586G>A	uc002top.2	+	31	4227	c.4174G>A	c.(4174-4176)GTG>ATG	p.V1392M	MYO7B_uc002toq.1_Missense_Mutation_p.V245M|MYO7B_uc002tor.1_Missense_Mutation_p.V245M	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1392	FERM 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ACCACTGGCCGTGCGAGAGCA	0.612													7	7					0	0	0	0	A	128384586	A	A	128384586	3	1	304	1	0	0	0	0	1	0	0	0	10136	1145	40	1	4292	1	MYO7B	2	128384586	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	8189863	128384586	114814787	18	56305											
LCT	3938	broad.mit.edu	37	chr2	136575003	136575003	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccacggctcatggaaggTcacccacagcttcacacggt	10	6	9	16	2	3	0	3	0	0	0	3	1	3	1	2	4	1	2	2	4	1	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:136575003T>C	uc002tuu.1	-	6	1626	c.1615A>G	c.(1615-1617)ACC>GCC	p.T539A		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	539	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCATGGAAGGTCACCCACAGC	0.587													12	36					0	0	0	0	C	136575003	C	C	136575003	3	2	304	1	0	0	0	0	1	0	0	0	8733	1667	58	5	4216	5	LCT	2	136575003	Missense_Mutation	SNP	T	TCGA-IQ-7630-01A-11D-2078-08	8190417	136575003	106624370	19	56306											
GALNT3	2591	broad.mit.edu	37	chr2	166627124	166627124	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaaccaaaactattataaaGaaaaaaattactgcaccaag	24	7	3	7	0	0	1	0	0	0	1	0	1	0	1	2	0	4	1	2	0	13	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:166627124G>T	uc010fph.1	-	2	474	c.87C>A	c.(85-87)TTC>TTA	p.F29L	GALNT3_uc010fpi.1_Missense_Mutation_p.F29L|GALNT3_uc002udi.2_Missense_Mutation_p.F29L	NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	29	Helical; Signal-anchor for type II membrane protein; (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						CTATTATAAAGAAAAAAATTA	0.308													10	22					0.000442599	0.000464607	1	0	T	166627124	T	T	166627124	3	4	304	1	0	0	0	0	1	0	0	0	6249	933	33	2	1854	2	GALNT3	2	166627124	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	30052121	166627124	76572249	20	56307											
SLC19A3	80704	broad.mit.edu	37	chr2	228563678	228563678	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gtcacattgcttggtttcagGctgttcagctggcccttatt	5	16	10	10	0	3	0	3	0	0	0	3	0	3	0	1	3	2	5	1	3	1	6			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:228563678G>A	uc002vpi.2	-	3	842	c.753C>T	c.(751-753)AGC>AGT	p.S251S	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Silent_p.S247S	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	251	Cytoplasmic (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	TTGGTTTCAGGCTGTTCAGCT	0.473													22	40					0	0	0	0	A	228563678	A	A	228563678	2	1	304	1	0	0	0	0	0	0	0	1	14495	1194	42	4		4	SLC19A3	2	228563678	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	61936554	228563678	14635695	21	56308											
HES6	55502	broad.mit.edu	37	chr2	239147619	239147619	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acaggtcgtccccaggacccGgggggctgggtattggggat	6	7	18	10	2	0	0	0	0	0	0	2	2	1	2	3	8	0	2	3	8	1	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr2:239147619G>A	uc002vxz.2	-	4	659	c.524C>T	c.(523-525)CCG>CTG	p.P175L	HES6_uc002vya.2_Missense_Mutation_p.P173L|HES6_uc002vyb.2_3'UTR	NM_018645	NP_061115	Q96HZ4	HES6_HUMAN	hairy and enhancer of split 6 isoform a	175					cell differentiation	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1		Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.23e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.29e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.19e-08)|BRCA - Breast invasive adenocarcinoma(100;5.98e-05)|Lung(119;0.0086)|LUSC - Lung squamous cell carcinoma(224;0.0148)		CCCAGGACCCGGGGGGCTGGG	0.726													5	13					0	0	0	0	A	239147619	A	A	239147619	3	1	304	1	0	0	0	0	1	0	0	0	7109	1116	39	1	154	1	HES6	2	239147619	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	10583941	239147619	4051754	22	56309											
ITGA9	3680	broad.mit.edu	37	chr3	37523001	37523001	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcatcgctggaagaacatCtactatgaagccgaccacat	13	8	8	12	2	2	2	1	1	1	1	3	4	2	3	2	1	3	2	2	1	5	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr3:37523001C>T	uc003chd.2	+	4	500	c.447C>T	c.(445-447)ATC>ATT	p.I149I	ITGA9_uc003chc.2_Silent_p.I149I	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	149	Extracellular (Potential).|FG-GAP 2.				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		GGAAGAACATCTACTATGAAG	0.532													11	70					0	0	0	0	T	37523001	T	T	37523001	2	4	304	1	0	0	0	0	0	0	0	1	7922	903	32	2		2	ITGA9	3	37523001	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		37523001	160499429	23	56310											
FLNB	2317	broad.mit.edu	37	chr3	58145386	58145386	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	gcccctctggagccgtggagGagtgccacgtgtctgagctg	5	8	16	12	2	2	1	0	1	2	0	2	4	2	4	4	3	3	1	4	3	0	0	rs139262140		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr3:58145386G>A	uc003djj.2	+	42	7159	c.6994G>A	c.(6994-6996)GAG>AAG	p.E2332K	FLNB_uc010hne.2_Missense_Mutation_p.E2363K|FLNB_uc003djk.2_Missense_Mutation_p.E2321K|FLNB_uc010hnf.2_Missense_Mutation_p.E2308K|FLNB_uc003djl.2_Missense_Mutation_p.E2152K|FLNB_uc003djm.2_Missense_Mutation_p.E2139K	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2332	Filamin 22.|Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		AGCCGTGGAGGAGTGCCACGT	0.552													4	31					0	0	0	0	A	58145386	A	A	58145386	3	1	304	1	0	0	0	0	1	0	0	0	5966	1175	41	2	7257	2	FLNB	3	58145386	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	20622385	58145386	139877044	24	56311											
PXK	54899	broad.mit.edu	37	chr3	58395289	58395289	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atcgaagactgacaagagctCagtcccaccatggatctgag	13	7	10	11	1	2	4	1	2	1	2	4	6	3	5	2	1	1	1	2	1	2	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr3:58395289C>T	uc003djz.1	+	15	1438	c.1339C>T	c.(1339-1341)CAG>TAG	p.Q447*	PXK_uc003djx.1_Nonsense_Mutation_p.Q447*|PXK_uc003djy.1_Nonsense_Mutation_p.Q430*|PXK_uc003dka.1_Nonsense_Mutation_p.Q447*|PXK_uc003dkb.1_Nonsense_Mutation_p.Q364*|PXK_uc003dkc.1_Nonsense_Mutation_p.Q430*|PXK_uc011bfe.1_Nonsense_Mutation_p.Q414*|PXK_uc010hnj.1_Nonsense_Mutation_p.Q414*|PXK_uc003dkd.1_Nonsense_Mutation_p.Q310*|PXK_uc010hnk.1_Nonsense_Mutation_p.Q221*	NM_017771	NP_060241	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	447	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		GACAAGAGCTCAGTCCCACCA	0.418													4	27					0	0	0	0	T	58395289	T	T	58395289	4	4	304	1	0	0	0	0	0	1	0	0	12914	827	29	2	1397	2	PXK	3	58395289	Nonsense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	249903	58395289	139627141	25	56312											
ACOX2	8309	broad.mit.edu	37	chr3	58516345	58516345	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgtgctgtaccgagtttgacGtaggtgccatctggcaagac	8	11	13	9	2	1	2	0	1	1	1	1	3	1	2	2	2	3	5	2	2	3	3	rs142094321	byFrequency	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr3:58516345G>A	uc003dkl.2	-	8	1015	c.840C>T	c.(838-840)TAC>TAT	p.Y280Y		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	acyl-Coenzyme A oxidase 2	280					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		CGAGTTTGACGTAGGTGCCAT	0.597													7	16					0	0	0	0	A	58516345	A	A	58516345	2	1	304	1	0	0	0	0	0	0	0	1	159	1140	40	1		1	ACOX2	3	58516345	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	121056	58516345	139506085	26	56313											
KBTBD12	166348	broad.mit.edu	37	chr3	127703084	127703084	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tccccgagacctcatcccccCgccttcagatttggtggaag	7	9	9	16	2	2	2	2	0	0	2	4	4	4	3	7	2	0	0	7	2	1	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr3:127703084C>T	uc010hsr.2	+	5	1838	c.1835C>T	c.(1834-1836)CCG>CTG	p.P612L	KBTBD12_uc003ejy.3_Missense_Mutation_p.P219L|KBTBD12_uc010hsq.2_RNA|KBTBD12_uc003eka.3_Missense_Mutation_p.P187L	NM_207335	NP_997218	Q3ZCT8	KBTBC_HUMAN	kelch domain containing 6	612										ovary(1)	1						CTCATCCCCCCGCCTTCAGAT	0.537													21	32					0	0	0	0	T	127703084	T	T	127703084	3	4	304	1	0	0	0	0	1	0	0	0	8030	652	23	1	1853	1	KBTBD12	3	127703084	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	69186739	127703084	70319346	27	56314											
TRPC1	7220	broad.mit.edu	37	chr3	142511763	142511763	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaatgttctaagttatcttcGtctcttttttatgtatacaa	11	20	4	6	1	3	0	0	0	3	0	5	0	3	0	0	0	1	3	0	0	7	9			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr3:142511763G>A	uc003evc.2	+	9	1671	c.1535G>A	c.(1534-1536)CGT>CAT	p.R512H	TRPC1_uc003evb.2_Missense_Mutation_p.R478H|TRPC1_uc011bni.1_Intron	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	512	Extracellular (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AGTTATCTTCGTCTCTTTTTT	0.338													12	35					0	0	0	0	A	142511763	A	A	142511763	3	1	304	1	0	0	0	0	1	0	0	0	16645	1145	40	1	1463	1	TRPC1	3	142511763	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	14808679	142511763	55510667	28	56315											
GPR160	26996	broad.mit.edu	37	chr3	169801877	169801877	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cttgggaaaatattattaaaTatccttacactaggaatgag	16	13	7	5	0	0	1	0	1	0	0	1	3	1	3	1	2	1	0	1	2	10	7			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr3:169801877T>C	uc003fgi.2	+	4	707	c.117T>C	c.(115-117)AAT>AAC	p.N39N	GPR160_uc010hwq.2_Silent_p.N39N	NM_014373	NP_055188	Q9UJ42	GP160_HUMAN	G protein-coupled receptor 160	39	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_cancers(22;3.26e-22)|all_epithelial(15;5.71e-27)|all_lung(20;8.41e-17)|Lung NSC(18;3.49e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TATTATTAAATATCCTTACAC	0.328													19	34					0	0	0	0	C	169801877	C	C	169801877	2	2	304	1	0	0	0	0	0	0	0	1	6702	1403	49	5		5	GPR160	3	169801877	Silent	SNP	T	TCGA-IQ-7630-01A-11D-2078-08	27290114	169801877	28220553	29	56316											
HTR3D	200909	broad.mit.edu	37	chr3	183756386	183756386	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccagaagggaaataagggccCgggtctcacccccacccacc	11	3	10	17	1	1	1	1	0	1	1	2	2	1	2	6	3	0	0	6	3	3	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr3:183756386C>T	uc011bqv.1	+	7	1109	c.1109C>T	c.(1108-1110)CCG>CTG	p.P370L	HTR3D_uc003fmj.2_Missense_Mutation_p.P195L|HTR3D_uc011bqu.1_Missense_Mutation_p.P320L|HTR3D_uc010hxp.2_Missense_Mutation_p.P149L	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	370	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AATAAGGGCCCGGGTCTCACC	0.468													6	18					0	0	0	0	T	183756386	T	T	183756386	3	4	304	1	0	0	0	0	1	0	0	0	7486	652	23	1	1305	1	HTR3D	3	183756386	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	13954509	183756386	14266044	30	56317											
ZFYVE28	57732	broad.mit.edu	37	chr4	2307028	2307028	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ccccgccctgtggaccatgcGgctgagctgctccagctcct	4	8	11	18	2	0	1	0	1	0	0	2	2	2	2	6	2	4	4	6	2	0	0	rs145750553		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr4:2307028G>A	uc003gex.1	-	8	1358	c.1039C>T	c.(1039-1041)CGC>TGC	p.R347C	ZFYVE28_uc011bvk.1_Missense_Mutation_p.R277C|ZFYVE28_uc011bvl.1_Missense_Mutation_p.R317C|ZFYVE28_uc003gew.1_Missense_Mutation_p.R233C	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	347					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						TGGACCATGCGGCTGAGCTGC	0.657													9	40					0	0	0	0	A	2307028	A	A	2307028	3	1	304	1	0	0	0	0	1	0	0	0	17737	1116	39	1	1648	1	ZFYVE28	4	2307028	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08		2307028	188847248	31	56318											
GBA3	57733	broad.mit.edu	37	chr4	22737769	22737769	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gcttggattgactcattaccGcttctctctttcctggtcac	5	16	7	13	1	4	1	2	1	2	0	6	2	5	2	2	2	1	2	2	2	1	5			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr4:22737769G>T	uc003gqp.3	+	2	315	c.224G>T	c.(223-225)CGC>CTC	p.R75L	GBA3_uc010iep.2_Missense_Mutation_p.R75L|GBA3_uc011bxo.1_Missense_Mutation_p.R76L	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	75					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						ACTCATTACCGCTTCTCTCTT	0.433													28	84					6.07407e-21	6.95225e-21	1	0	T	22737769	T	T	22737769	3	4	304	1	0	0	0	0	1	0	0	0	6303	1087	38	3	230	3	GBA3	4	22737769	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	20430741	22737769	168416507	32	56319											
GBA3	57733	broad.mit.edu	37	chr4	22820363	22820363	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gctatccaacttgataaagtCaatcttcaagtatattgtgc	13	14	6	8	0	3	1	2	1	1	0	4	1	4	1	1	0	2	2	1	0	8	7			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr4:22820363C>G	uc003gqp.3	+	5	1318	c.1227C>G	c.(1225-1227)GTC>GTG	p.V409V	GBA3_uc010iep.2_Silent_p.V102V|GBA3_uc011bxo.1_Silent_p.V410V	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	409					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						TTGATAAAGTCAATCTTCAAG	0.393													7	12					0	0	0	0	G	22820363	G	G	22820363	2	3	304	1	0	0	0	0	0	0	0	1	6303	813	29	2		2	GBA3	4	22820363	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	82594	22820363	168333913	33	56320											
PGM2	55276	broad.mit.edu	37	chr4	37848660	37848660	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	cgcagtgctctcaaagacacGtacatgttgtccagcaccgt	10	9	9	13	3	1	1	1	0	1	1	3	1	2	1	2	0	3	5	2	0	2	2	rs146573335	by1000genomes	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr4:37848660G>A	uc011byb.1	+	9	1189	c.1116G>A	c.(1114-1116)ACG>ACA	p.T372T	PGM2_uc011bya.1_Silent_p.T233T|PGM2_uc011byc.1_Silent_p.T212T	NM_018290	NP_060760	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	372					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			ovary(1)	1						TCAAAGACACGTACATGTTGT	0.498													37	104					0	0	0	0	A	37848660	A	A	37848660	2	1	304	1	0	0	0	0	0	0	0	1	11853	1132	40	1		1	PGM2	4	37848660	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	15028297	37848660	153305616	34	56321											
C4orf33	132321	broad.mit.edu	37	chr4	130030466	130030466	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atcttaattttgacagccacGgacagcatttagtgctttta	11	15	7	8	1	1	1	0	1	1	0	1	2	1	2	1	1	3	2	1	1	3	7			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr4:130030466G>A	uc003igu.3	+	4	611	c.247G>A	c.(247-249)GGA>AGA	p.G83R	C4orf33_uc010ioc.1_Missense_Mutation_p.G83R|C4orf33_uc010iod.2_Missense_Mutation_p.G83R	NM_173487	NP_775758	Q8N1A6	CD033_HUMAN	hypothetical protein LOC132321	83										upper_aerodigestive_tract(1)	1						TGACAGCCACGGACAGCATTT	0.328													27	87					0	0	0	0	A	130030466	A	A	130030466	3	1	304	1	0	0	0	0	1	0	0	0	2273	1117	39	1	257	1	C4orf33	4	130030466	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	92181806	130030466	61123810	35	56322											
CTNND2	1501	broad.mit.edu	37	chr5	11346651	11346651	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ccggcggcatagctggccctCtggaaggtggccgcggcggc	4	5	18	14	5	1	0	0	0	1	0	1	1	1	1	3	8	1	2	3	8	2	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr5:11346651C>G	uc003jfa.1	-	9	1606	c.1461G>C	c.(1459-1461)CAG>CAC	p.Q487H	CTNND2_uc010itt.2_Missense_Mutation_p.Q396H|CTNND2_uc011cmy.1_Missense_Mutation_p.Q150H|CTNND2_uc011cmz.1_Missense_Mutation_p.Q54H|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.Q54H	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	487					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						AGCTGGCCCTCTGGAAGGTGG	0.642													19	103					0	0	0	0	G	11346651	G	G	11346651	3	3	304	1	0	0	0	0	1	0	0	0	4037	912	32	2	2272	2	CTNND2	5	11346651	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		11346651	169568609	36	56323											
BRIX1	55299	broad.mit.edu	37	chr5	34924964	34924964	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tattaaagatcatagaagaaGatgctgctcttgtagaaata	17	12	8	4	0	2	5	1	0	1	5	2	5	2	5	0	0	2	3	0	0	9	6			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr5:34924964G>A	uc003jja.2	+	9	700	c.676G>A	c.(676-678)GAT>AAT	p.D226N		NM_018321	NP_060791	Q8TDN6	BRX1_HUMAN	BRIX	226	Brix.				ribosome biogenesis|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|protein binding				0						CATAGAAGAAGATGCTGCTCT	0.338													9	68					0	0	0	0	A	34924964	A	A	34924964	3	1	304	1	0	0	0	0	1	0	0	0	1520	942	33	2	710	2	BRIX1	5	34924964	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	23578313	34924964	145990296	37	56324											
RASA1	5921	broad.mit.edu	37	chr5	86675667	86675668	+	Splice_Site	DNP	CG	TT	TT																															ggcttcagaaatacttccacCgtaagtggtgaaattttcat																								rs138785106	by1000genomes	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr5:86675667_86675668CG>TT	uc003kiw.2	+	19	2721	c.2603_splice	c.e19+1	p.P868_splice	RASA1_uc010jav.2_Splice_Site|RASA1_uc003kix.2_Splice_Site_p.P691_splice|RASA1_uc011ctv.1_Splice_Site_p.P701_splice|RASA1_uc011ctw.1_Splice_Site_p.P702_splice|RASA1_uc010jaw.2_Splice_Site_p.P690_splice	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1						cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		ATACTTCCACCGTAAGTGGTGA	0.302													19	27					0	0	0	0	TT	86675668	TT	TT	86675667	5	4	304	1	0	0	0	0	0	0	1	0	13125	666	23	1	2689	1	RASA1	5	86675667	Splice_Site	DNP	CG	TCGA-IQ-7630-01A-11D-2078-08	51750703	86675667	94239593	38	56325											
SNX24	28966	broad.mit.edu	37	chr5	122337107	122337107	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tcaaaacttttagatcttttGatgaaacagagtctgaagag	15	13	8	5	0	3	6	1	3	2	3	3	6	3	6	0	0	2	0	0	0	5	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr5:122337107G>C	uc011cwo.1	+	5	521	c.352G>C	c.(352-354)GAT>CAT	p.D118H	SNX24_uc003ktf.2_Missense_Mutation_p.D118H|SNX24_uc010jcy.2_Missense_Mutation_p.D118H	NM_014035	NP_054754	Q9Y343	SNX24_HUMAN	SBBI31 protein	118	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		TAGATCTTTTGATGAAACAGA	0.318													3	15					0	0	0	0	C	122337107	C	C	122337107	3	2	304	1	0	0	0	0	1	0	0	0	14959	1290	45	2	370	2	SNX24	5	122337107	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	35661440	122337107	58578153	39	56326											
PCDHA7	56141	broad.mit.edu	37	chr5	140216300	140216300	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ccttcagtcccagccttcctCagggtccatcctctacagac	7	10	6	18	0	3	1	2	0	1	1	7	1	7	1	6	1	2	0	6	1	1	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr5:140216300C>T	uc003lhq.2	+	1	2332	c.2332C>T	c.(2332-2334)CAG>TAG	p.Q778*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Nonsense_Mutation_p.Q778*	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	778	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCCTTCCTCAGGGTCCATC	0.478													20	11					0	0	0	0	T	140216300	T	T	140216300	4	4	304	1	0	0	0	0	0	1	0	0	11583	827	29	2	2334	2	PCDHA7	5	140216300	Nonsense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	17879193	140216300	40698960	40	56327											
PCDHGA11	56105	broad.mit.edu	37	chr5	140801398	140801398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tagtactggagggaagcctgGaccgagagaaagaggctgct	12	6	16	7	1	0	2	0	0	0	2	0	7	0	5	2	4	3	3	2	4	4	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr5:140801398G>A	uc003lkq.1	+	1	862	c.604G>A	c.(604-606)GAC>AAC	p.D202N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.D202N|PCDHGA11_uc003lkp.1_Missense_Mutation_p.D202N	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	202	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAAGCCTGGACCGAGAGAA	0.562													12	30					0	0	0	0	A	140801398	A	A	140801398	3	1	304	1	0	0	0	0	1	0	0	0	11606	1174	41	2	606	2	PCDHGA11	5	140801398	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	585098	140801398	40113862	41	56328											
GPLD1	2822	broad.mit.edu	37	chr6	24437398	24437398	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gccaccaaatcgggagaagcGgcggtctccgctgaaggtgc	9	5	15	12	4	1	2	0	1	1	1	3	3	1	2	3	4	2	1	3	4	3	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr6:24437398G>A	uc003ned.1	-	21	2251	c.2140C>T	c.(2140-2142)CGC>TGC	p.R714C		NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	714	FG-GAP 6.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						CGGGAGAAGCGGCGGTCTCCG	0.552													15	43					0	0	0	0	A	24437398	A	A	24437398	3	1	304	1	0	0	0	0	1	0	0	0	6652	1116	39	1	402	1	GPLD1	6	24437398	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08		24437398	146677669	42	56329											
TNXB	7148	broad.mit.edu	37	chr6	32049423	32049424	+	Frame_Shift_Ins	INS	-	G	G																															ctgctccaggaactcagggcINSgggggggctcctctttcctc																								rs12211410	by1000genomes	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr6:32049423_32049424insG	uc003nzl.2	-	10	3965_3966	c.3763_3764insC	c.(3763-3765)CGCfs	p.R1255fs		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1342					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GAACTCAGGGCGGGGGGGCTCC	0.639													---	---	---								G	32049424	G	G	32049423	7	5	304	1	0	1	1	0	0	0	0	0	16412	768	27	0	11089	0	TNXB	6	32049423	Frame_Shift_Ins	INS	-	TCGA-IQ-7630-01A-11D-2078-08	7612025	32049423	139065644	43	56330											
DNAH8	1769	broad.mit.edu	37	chr6	38825334	38825334	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	gatgttgtggacacacgattCagaagaggctttacgtaatg	12	11	12	6	2	1	2	1	0	0	2	1	5	1	3	0	2	1	3	0	2	3	5			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr6:38825334C>G	uc003ooe.1	+	40	5723	c.5123C>G	c.(5122-5124)TCA>TGA	p.S1708*		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ACACACGATTCAGAAGAGGCT	0.348													14	41					0	0	0	0	G	38825334	G	G	38825334	4	3	304	1	0	0	0	0	0	1	0	0	4629	838	29	2	5273	2	DNAH8	6	38825334	Nonsense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	6775911	38825334	132289733	44	56331											
CUL9	23113	broad.mit.edu	37	chr6	43152214	43152214	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	aagtgggcaaagtgggtgtgGaagaaggcaaagcagagcac	15	4	17	5	0	0	2	0	0	0	2	0	3	0	3	0	4	2	4	0	4	5	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr6:43152214G>A	uc003ouk.2	+	2	241	c.166G>A	c.(166-168)GAA>AAA	p.E56K	CUL9_uc003ouj.1_Missense_Mutation_p.E56K|CUL9_uc003oul.2_Missense_Mutation_p.E56K|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	56					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						AGTGGGTGTGGAAGAAGGCAA	0.562													18	37					0	0	0	0	A	43152214	A	A	43152214	3	1	304	1	0	0	0	0	1	0	0	0	4078	1175	41	2	168	2	CUL9	6	43152214	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	4326880	43152214	127962853	45	56332											
POPDC3	64208	broad.mit.edu	37	chr6	105606599	105606599	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tctcctccaagacacatatcGacaatcagtttctgcagtga	12	11	6	12	1	3	2	1	1	2	1	6	3	4	2	2	0	1	2	2	0	3	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr6:105606599G>A	uc003prb.2	-	4	1024	c.622C>T	c.(622-624)CGA>TGA	p.R208*	uc003pqz.2_Intron|POPDC3_uc003pra.2_RNA	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	208						integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				GACACATATCGACAATCAGTT	0.413													20	103					0	0	0	0	A	105606599	A	A	105606599	4	1	304	1	0	0	0	0	0	1	0	0	12311	1066	37	1	257	1	POPDC3	6	105606599	Nonsense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	62454385	105606599	65508468	46	56333											
PDSS2	57107	broad.mit.edu	37	chr6	107780282	107780282	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	ctcgtcgctcagcaggcagcGaaggctcatgaaggacgtgg	9	6	15	11	4	2	1	2	1	0	0	4	3	2	2	0	4	2	4	0	4	2	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr6:107780282G>C	uc003prt.2	-	1	498	c.208C>G	c.(208-210)CGC>GGC	p.R70G	PDSS2_uc011eak.1_Intron|PDSS2_uc011eal.1_Missense_Mutation_p.R70G|PDSS2_uc003pru.2_Missense_Mutation_p.R70G|PDSS2_uc003prv.2_Missense_Mutation_p.R70G	NM_020381	NP_065114	Q86YH6	DLP1_HUMAN	prenyl diphosphate synthase, subunit 2	70					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			ovary(2)	2	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)		AGCAGGCAGCGAAGGCTCATG	0.622											OREG0017595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	36					0	0	0	0	C	107780282	C	C	107780282	3	2	304	1	0	0	0	0	1	0	0	0	11748	1058	37	3	1023	3	PDSS2	6	107780282	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	2173683	107780282	63334785	47	56334											
LACE1	246269	broad.mit.edu	37	chr6	108723212	108723212	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tctttcagatctctataaaaAtggactccaaagagctaact	15	12	5	9	0	3	2	1	0	2	2	5	3	4	3	1	1	2	1	1	1	6	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr6:108723212A>G	uc003psj.2	+	7	947	c.761A>G	c.(760-762)AAT>AGT	p.N254S		NM_145315	NP_660358	Q8WV93	LACE1_HUMAN	lactation elevated 1	254							ATP binding			central_nervous_system(1)	1		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		CTCTATAAAAATGGACTCCAA	0.284													3	11					0	0	0	0	G	108723212	G	G	108723212	3	3	304	1	0	0	0	0	1	0	0	0	8635	101	4	5	787	5	LACE1	6	108723212	Missense_Mutation	SNP	A	TCGA-IQ-7630-01A-11D-2078-08	942930	108723212	62391855	48	56335											
LAMA2	3908	broad.mit.edu	37	chr6	129714240	129714240	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaagctgtttggagagtcccGgggggaaaatgaagaaatgg	13	7	17	4	1	0	3	0	1	0	2	1	6	1	4	1	5	1	2	1	5	5	1	rs138296015	by1000genomes	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr6:129714240G>C	uc003qbn.2	+	37	5390	c.5285G>C	c.(5284-5286)CGG>CCG	p.R1762P	LAMA2_uc003qbo.2_Missense_Mutation_p.R1762P	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1762	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GGAGAGTCCCGGGGGGAAAAT	0.468													13	47					0	0	0	0	C	129714240	C	C	129714240	3	2	304	1	0	0	0	0	1	0	0	0	8646	1116	39	3	5431	3	LAMA2	6	129714240	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	20991028	129714240	41400827	49	56336											
L3MBTL3	84456	broad.mit.edu	37	chr6	130425615	130425615	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aatcaatttgaataaagaccGtatttttccagaccgcttaa	15	13	5	8	2	1	3	1	1	0	2	2	3	2	3	3	0	0	2	3	0	7	6			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr6:130425615G>A	uc003qbt.2	+	19	1951	c.1781G>A	c.(1780-1782)CGT>CAT	p.R594H	L3MBTL3_uc003qbu.2_Missense_Mutation_p.R569H	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	594					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		AATAAAGACCGTATTTTTCCA	0.383													31	61					0	0	0	0	A	130425615	A	A	130425615	3	1	304	1	0	0	0	0	1	0	0	0	8633	1145	40	1	1847	1	L3MBTL3	6	130425615	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	711375	130425615	40689452	50	56337											
C7orf46	340277	broad.mit.edu	37	chr7	23731200	23731200	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	cggaaggctacatgcggttaGatgacagtgggattggtaag	11	9	16	5	2	0	2	0	1	0	1	0	4	0	4	0	5	2	3	0	5	4	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr7:23731200G>C	uc003swo.3	+	4	711	c.622G>C	c.(622-624)GAT>CAT	p.D208H	C7orf46_uc003swq.3_Missense_Mutation_p.D208H|C7orf46_uc003swr.3_Missense_Mutation_p.D150H|C7orf46_uc003swp.3_RNA|C7orf46_uc010kup.2_RNA	NM_199136	NP_954587	A4D161	CG046_HUMAN	hypothetical protein LOC340277 isoform 1	208											0						CATGCGGTTAGATGACAGTGG	0.423													23	52					0	0	0	0	C	23731200	C	C	23731200	3	2	304	1	0	0	0	0	1	0	0	0	2407	942	33	2	636	2	C7orf46	7	23731200	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08		23731200	135407463	51	56338											
EGFR	1956	broad.mit.edu	37	chr7	55233012	55233012	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agtgtgcccactacattgacGgcccccactgcgtcaagacc	9	7	9	16	2	1	2	1	1	0	1	1	2	1	2	4	1	3	0	4	1	2	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr7:55233012G>A	uc003tqk.2	+	15	2008	c.1762G>A	c.(1762-1764)GGC>AGC	p.G588S	EGFR_uc003tqi.2_Missense_Mutation_p.G588S|EGFR_uc003tqj.2_Missense_Mutation_p.G588S|EGFR_uc010kzg.1_Missense_Mutation_p.G543S|EGFR_uc011kco.1_Missense_Mutation_p.G535S|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	588	Approximate.|Extracellular (Potential).			DGPH->AGPA: Decreases intramolecular interactions and facilitates EGF binding.	activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTACATTGACGGCCCCCACTG	0.532		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			23	43					0	0	0	0	A	55233012	A	A	55233012	3	1	304	1	0	0	0	0	1	0	0	0	4989	1116	39	1	1831	1	EGFR	7	55233012	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	31501812	55233012	103905651	52	56339											
ZAN	7455	broad.mit.edu	37	chr7	100391590	100391590	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatgcctacagtggcacccaGagcctcccctggctgactgt	7	9	10	15	0	0	2	0	1	0	1	1	2	1	2	5	2	3	2	5	2	2	2	rs143981169	by1000genomes	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr7:100391590G>A	uc003uwj.2	+	44	8101	c.7936G>A	c.(7936-7938)GAG>AAG	p.E2646K	ZAN_uc003uwk.2_Intron|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_Intron|ZAN_uc010lhi.2_Intron|ZAN_uc011kke.1_Intron	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2646	Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GTGGCACCCAGAGCCTCCCCT	0.672													5	17					0	0	0	0	A	100391590	A	A	100391590	3	1	304	1	0	0	0	0	1	0	0	0	17581	943	33	2	8166	2	ZAN	7	100391590	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	45158578	100391590	58747073	53	56340											
MUC17	140453	broad.mit.edu	37	chr7	100686824	100686824	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctctacttctgtcaccaccCgtcctgtgaccccttcatca	6	12	4	19	1	5	1	3	1	2	0	6	1	6	1	6	0	1	0	6	0	1	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr7:100686824C>T	uc003uxp.1	+	3	12180	c.12127C>T	c.(12127-12129)CGT>TGT	p.R4043C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4043	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TGTCACCACCCGTCCTGTGAC	0.537													40	106					0	0	0	0	T	100686824	T	T	100686824	3	4	304	1	0	0	0	0	1	0	0	0	10027	652	23	1	12137	1	MUC17	7	100686824	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	295234	100686824	58451839	54	56341											
CUX1	1523	broad.mit.edu	37	chr7	101840038	101840038	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tccaatactaatggtacacaCcagttctcaccagcggggtt	11	10	8	12	1	1	0	1	0	1	0	3	0	2	0	3	3	3	3	3	3	4	5			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr7:101840038C>T	uc003uyx.3	+	15	1385	c.1347C>T	c.(1345-1347)CAC>CAT	p.H449H	CUX1_uc003uys.3_Silent_p.H460H|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	449					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						ATGGTACACACCAGTTCTCAC	0.572													30	73					0	0	0	0	T	101840038	T	T	101840038	2	4	304	1	0	0	0	0	0	0	0	1	4081	506	18	4		4	CUX1	7	101840038	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	1153214	101840038	57298625	55	56342											
KCND2	3751	broad.mit.edu	37	chr7	119915562	119915562	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	agcggagcctttgtcacactCcgagtcttccgggtcttcag	6	11	11	13	3	4	0	2	0	2	0	6	2	6	1	3	2	2	0	3	2	0	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr7:119915562C>T	uc003vjj.1	+	1	1841	c.876C>T	c.(874-876)CTC>CTT	p.L292L		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	292	Helical; Voltage-sensor; Name=Segment S4; (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					TTGTCACACTCCGAGTCTTCC	0.527													12	23					0	0	0	0	T	119915562	T	T	119915562	2	4	304	1	0	0	0	0	0	0	0	1	8058	842	30	2		2	KCND2	7	119915562	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	18075524	119915562	39223101	56	56343											
PAX4	5078	broad.mit.edu	37	chr7	127255554	127255554	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aggggccggccattcacaaaGagccccccaagctggttcat	10	6	11	14	1	2	1	2	0	0	1	2	1	2	1	5	4	2	2	5	4	2	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr7:127255554G>C	uc010lld.1	-	1	227	c.21C>G	c.(19-21)CTC>CTG	p.L7L	PAX4_uc003vmf.2_5'UTR|PAX4_uc003vmg.1_Silent_p.L7L|PAX4_uc003vmh.2_5'UTR	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	15	Paired.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CATTCACAAAGAGCCCCCCAA	0.617													15	81					0	0	0	0	C	127255554	C	C	127255554	2	2	304	1	0	0	0	0	0	0	0	1	11535	929	33	2		2	PAX4	7	127255554	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	7339992	127255554	31883109	57	56344											
SSBP1	6742	broad.mit.edu	37	chr7	141445354	141445354	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aatacatggataaaaataatGtgaggcgacaagcaacaaca	21	6	8	6	1	0	1	0	1	0	0	0	3	0	2	0	2	4	1	0	2	9	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr7:141445354G>T	uc003vwo.1	+	6	451	c.373G>T	c.(373-375)GTG>TTG	p.V125L	SSBP1_uc011kri.1_Missense_Mutation_p.V125L|SSBP1_uc010lnp.1_Missense_Mutation_p.V125L	NM_003143	NP_003134	Q04837	SSBP_HUMAN	single-stranded DNA binding protein 1 precursor	125	SSB.				DNA replication|positive regulation of helicase activity	mitochondrial nucleoid	single-stranded DNA binding			ovary(1)	1	Melanoma(164;0.0171)					TAAAAATAATGTGAGGCGACA	0.313													15	40					4.7546e-09	5.19181e-09	1	0	T	141445354	T	T	141445354	3	4	304	1	0	0	0	0	1	0	0	0	15245	1377	48	4	391	4	SSBP1	7	141445354	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	14189800	141445354	17693309	58	56345											
KRBA1	84626	broad.mit.edu	37	chr7	149430329	149430329	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggctgctcccccagggcccGcctgagctgcccagtgagtc	5	6	13	17	1	0	2	0	2	0	0	2	2	1	2	5	2	3	3	5	2	0	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr7:149430329G>A	uc003wfz.2	+	18	2685	c.2286G>A	c.(2284-2286)CCG>CCA	p.P762P	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Silent_p.P369P	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	762	Pro-rich.									ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCAGGGCCCGCCTGAGCTGC	0.647													39	114					0	0	0	0	A	149430329	A	A	149430329	2	1	304	1	0	0	0	0	0	0	0	1	8478	1074	38	1		1	KRBA1	7	149430329	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	7984975	149430329	9708334	59	56346											
CA8	767	broad.mit.edu	37	chr8	61178601	61178601	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttgaggcaatggtcctccCgaaagaactgaaaaagaaaa	17	6	9	9	1	0	4	0	2	0	2	2	5	2	4	3	2	1	1	3	2	7	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr8:61178601C>T	uc003xtz.1	-	3	548	c.300G>A	c.(298-300)TCG>TCA	p.S100S	CA8_uc003xua.1_Silent_p.S100S|CA8_uc003xub.2_Silent_p.S100S	NM_004056	NP_004047	P35219	CAH8_HUMAN	carbonic anhydrase VIII	100			S -> P (in CMARQ3; affects protein stability owing to accelerated proteasomal degradation).		one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				ATGGTCCTCCCGAAAGAACTG	0.388													11	30					0	0	0	0	T	61178601	T	T	61178601	2	4	304	1	0	0	0	0	0	0	0	1	2535	639	23	1		1	CA8	8	61178601	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		61178601	85185421	60	56347											
KCNS2	3788	broad.mit.edu	37	chr8	99440583	99440583	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gcagctacagctaccatggcCgcaaagtagagcccgagcag	12	4	12	13	2	0	1	0	0	0	1	0	2	0	1	3	1	6	6	3	1	4	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr8:99440583C>T	uc003yin.2	+	2	726	c.376C>T	c.(376-378)CGC>TGC	p.R126C		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	126	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CTACCATGGCCGCAAAGTAGA	0.552													20	40					0	0	0	0	T	99440583	T	T	99440583	3	4	304	1	0	0	0	0	1	0	0	0	8128	652	23	1	378	1	KCNS2	8	99440583	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	38261982	99440583	46923439	61	56348											
VPS13B	157680	broad.mit.edu	37	chr8	100729474	100729474	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagtctcaaagaaagaagccGcattctgataggaccatgtt	15	9	9	8	1	2	3	1	1	2	2	3	4	2	4	2	1	1	2	2	1	5	3	rs147099791	by1000genomes	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr8:100729474G>A	uc003yiv.2	+	37	6716	c.6605G>A	c.(6604-6606)CGC>CAC	p.R2202H	VPS13B_uc003yiw.2_Missense_Mutation_p.R2177H	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2202					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GAAAGAAGCCGCATTCTGATA	0.393													28	32					0	0	0	0	A	100729474	A	A	100729474	3	1	304	1	0	0	0	0	1	0	0	0	17258	1087	38	1	6941	1	VPS13B	8	100729474	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	1288891	100729474	45634548	62	56349											
PHF20L1	51105	broad.mit.edu	37	chr8	133848943	133848943	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gatgtatttgtgagatggatGaggagaatggcttcatgatc	11	13	14	3	0	1	4	1	3	0	2	2	8	1	5	0	3	0	2	0	3	2	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr8:133848943G>A	uc003ytt.2	+	16	2393	c.2068G>A	c.(2068-2070)GAG>AAG	p.E690K	PHF20L1_uc011lja.1_Missense_Mutation_p.E664K	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	690	PHD-type.						nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGAGATGGATGAGGAGAATGG	0.388													14	70					0	0	0	0	A	133848943	A	A	133848943	3	1	304	1	0	0	0	0	1	0	0	0	11887	1291	45	2	2222	2	PHF20L1	8	133848943	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	33119469	133848943	12515079	63	56350											
NRBP2	340371	broad.mit.edu	37	chr8	144919579	144919579	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgggtgctgactgctcacCgccactgcagcgggggcctg	4	8	15	14	2	2	1	1	1	1	0	2	1	2	1	3	3	4	3	3	3	0	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr8:144919579C>T	uc011lkt.1	-	12	1216	c.1076G>A	c.(1075-1077)CGG>CAG	p.R359Q	NRBP2_uc003yzv.2_Missense_Mutation_p.R116Q|NRBP2_uc003yzz.1_5'Flank|NRBP2_uc003yzw.2_Missense_Mutation_p.R151Q|NRBP2_uc010mfl.2_Missense_Mutation_p.R151Q|NRBP2_uc010mfm.2_Missense_Mutation_p.R116Q|NRBP2_uc011lks.1_Missense_Mutation_p.R116Q|NRBP2_uc003yzy.2_Missense_Mutation_p.R116Q	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	359					negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GACTGCTCACCGCCACTGCAG	0.532													4	9					0	0	0	0	T	144919579	T	T	144919579	3	4	304	1	0	0	0	0	1	0	0	0	10697	666	23	1	457	1	NRBP2	8	144919579	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	11070636	144919579	1444443	64	56351											
UNC13B	10497	broad.mit.edu	37	chr9	35377547	35377547	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgaaggaccgcatgaagatCcgagagcgaaataagccaga	17	4	12	8	3	0	5	0	2	0	3	1	8	1	6	3	1	2	1	3	1	4	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr9:35377547C>T	uc003zwq.2	+	15	1963	c.1671C>T	c.(1669-1671)ATC>ATT	p.I557I	UNC13B_uc003zwr.2_Silent_p.I557I	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	557					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GCATGAAGATCCGAGAGCGAA	0.507													16	265					0	0	0	0	T	35377547	T	T	35377547	2	4	304	1	0	0	0	0	0	0	0	1	17053	845	30	2		2	UNC13B	9	35377547	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		35377547	105835884	65	56352											
TLN1	7094	broad.mit.edu	37	chr9	35724888	35724888	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttagagtcatccaccatgatCgtcttcacagttccatccag	10	12	6	13	1	3	2	2	1	1	1	7	2	6	2	4	0	0	1	4	0	1	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr9:35724888C>T	uc003zxt.2	-	4	651	c.297G>A	c.(295-297)ACG>ACA	p.T99T	TLN1_uc003zxu.3_Silent_p.T99T	NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	99	FERM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CCACCATGATCGTCTTCACAG	0.512													21	198					0	0	0	0	T	35724888	T	T	35724888	2	4	304	1	0	0	0	0	0	0	0	1	16013	871	31	1		1	TLN1	9	35724888	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	347341	35724888	105488543	66	56353											
TMEM2	23670	broad.mit.edu	37	chr9	74305092	74305092	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttttttccgtcaagcggaatGgaacgctgcacggatccaca	10	10	10	11	4	1	0	1	0	0	0	3	3	3	3	2	3	3	2	2	3	3	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr9:74305092G>A	uc011lsa.1	-	22	4307	c.3767C>T	c.(3766-3768)CCA>CTA	p.P1256L	TMEM2_uc011lrz.1_Missense_Mutation_p.P249L|TMEM2_uc010mos.2_Missense_Mutation_p.P1193L|TMEM2_uc011lsb.1_RNA|TMEM2_uc004aik.2_Missense_Mutation_p.P90L	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1256						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CAAGCGGAATGGAACGCTGCA	0.478													23	74					0	0	0	0	A	74305092	A	A	74305092	3	1	304	1	0	0	0	0	1	0	0	0	16187	1348	47	4	396	4	TMEM2	9	74305092	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	38580204	74305092	66908339	67	56354											
VPS13A	23230	broad.mit.edu	37	chr9	79840885	79840885	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ctttaatataactatagctaGacagacggcagaagttgagg	15	10	10	6	1	0	4	0	1	0	3	0	4	0	4	0	2	2	3	0	2	7	8			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr9:79840885G>A	uc004akr.2	+	14	1465	c.1205G>A	c.(1204-1206)AGA>AAA	p.R402K	VPS13A_uc004akp.3_Missense_Mutation_p.R402K|VPS13A_uc004akq.3_Missense_Mutation_p.R402K|VPS13A_uc004aks.2_Missense_Mutation_p.R402K	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	402	TPR 2.				Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						ACTATAGCTAGACAGACGGCA	0.264													23	89					0	0	0	0	A	79840885	A	A	79840885	3	1	304	1	0	0	0	0	1	0	0	0	17257	942	33	2	1259	2	VPS13A	9	79840885	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	5535793	79840885	61372546	68	56355											
NEBL	10529	broad.mit.edu	37	chr10	21106596	21106596	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gatcagaaattgcagttcccCgttgaagttctcccttatat	10	14	7	10	1	2	2	1	1	1	1	4	3	3	2	3	0	1	4	3	0	4	6			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr10:21106596C>T	uc001iqi.2	-	21	2478	c.2081G>A	c.(2080-2082)CGG>CAG	p.R694Q	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	694	Nebulin 20.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TGCAGTTCCCCGTTGAAGTTC	0.383													15	56					0	0	0	0	T	21106596	T	T	21106596	3	4	304	1	0	0	0	0	1	0	0	0	10357	652	23	1	995	1	NEBL	10	21106596	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		21106596	114428151	69	56356											
RBP3	5949	broad.mit.edu	37	chr10	48390514	48390514	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	accctccagaacctcatggcGgaggcccctttgcagccagg	8	6	11	16	1	1	1	1	0	0	1	2	2	2	2	6	4	3	1	6	4	1	1	rs150932600	by1000genomes	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr10:48390514G>A	uc001jez.2	-	1	478	c.364C>T	c.(364-366)CGC>TGC	p.R122C		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	122	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	ACCTCATGGCGGAGGCCCCTT	0.642													29	70					0	0	0	0	A	48390514	A	A	48390514	3	1	304	1	0	0	0	0	1	0	0	0	13222	1116	39	1	3395	1	RBP3	10	48390514	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	27283918	48390514	87144233	70	56357											
PLA2G12B	84647	broad.mit.edu	37	chr10	74700977	74700977	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	gcttaaggtcagagcagatcGagtggagacaccatcggaat	13	7	13	8	2	1	3	1	0	0	3	3	6	1	4	1	3	1	2	1	3	2	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr10:74700977G>C	uc001jtf.1	-	3	483	c.416C>G	c.(415-417)TCG>TGG	p.S139W	PLA2G12B_uc009xqt.1_Missense_Mutation_p.S49W|PLA2G12B_uc010qjz.1_Missense_Mutation_p.S139W	NM_032562	NP_115951	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB precursor	139					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			ovary(1)	1	Prostate(51;0.0198)					AGAGCAGATCGAGTGGAGACA	0.498													25	70					0	0	0	0	C	74700977	C	C	74700977	3	2	304	1	0	0	0	0	1	0	0	0	12046	1059	37	3	179	3	PLA2G12B	10	74700977	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	26310463	74700977	60833770	71	56358											
ADRB1	153	broad.mit.edu	37	chr10	115804437	115804437	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cggggcctcgtgtgcaccgtGtgggccatctcggccctggt	2	9	16	14	4	1	0	0	0	1	0	3	0	1	0	4	5	1	1	4	5	0	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr10:115804437G>A	uc001lba.2	+	1	632	c.546G>A	c.(544-546)GTG>GTA	p.V182V		NM_000684	NP_000675	P08588	ADRB1_HUMAN	beta-1-adrenergic receptor	182	Helical; Name=4; (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	TGTGCACCGTGTGGGCCATCT	0.587													11	20					0	0	0	0	A	115804437	A	A	115804437	2	1	304	1	0	0	0	0	0	0	0	1	340	1364	48	4		4	ADRB1	10	115804437	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	41103460	115804437	19730310	72	56359											
CYP2R1	120227	broad.mit.edu	37	chr11	14913703	14913703	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaagagcagcaggaagagcgCgccgccgagcgccgccgcgc	9	0	17	15	8	0	2	0	0	0	2	0	5	0	3	4	1	4	2	4	1	2	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr11:14913703C>T	uc001mlr.2	-	1	49	c.49G>A	c.(49-51)GCG>ACG	p.A17T	CYP2R1_uc001mlo.2_5'Flank|CYP2R1_uc001mlp.2_5'Flank|CYP2R1_uc001mlq.2_5'Flank	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	17					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	AGGAAGAGCGCGCCGCCGAGC	0.701													10	17					0	0	0	0	T	14913703	T	T	14913703	3	4	304	1	0	0	0	0	1	0	0	0	4190	768	27	1	1476	1	CYP2R1	11	14913703	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		14913703	120092813	73	56360											
ANO5	203859	broad.mit.edu	37	chr11	22272376	22272376	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttattggagactaaatagtaCgtgtttggcttcaaaggtat	12	15	10	4	1	1	1	1	0	0	1	1	2	1	1	0	3	1	4	0	3	7	8			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr11:22272376C>T	uc001mqi.2	+	11	1420	c.1103C>T	c.(1102-1104)ACG>ATG	p.T368M	ANO5_uc001mqj.2_Missense_Mutation_p.T367M	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	368	Extracellular (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						CTAAATAGTACGTGTTTGGCT	0.368													39	49					0	0	0	0	T	22272376	T	T	22272376	3	4	304	1	0	0	0	0	1	0	0	0	700	536	19	1	1145	1	ANO5	11	22272376	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	7358673	22272376	112734140	74	56361											
OR4C6	219432	broad.mit.edu	37	chr11	55433179	55433179	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	gatcactttatatgtgatttGtttcagttgttgacacttgc	8	19	8	6	0	2	2	2	2	0	0	2	3	2	2	0	0	1	3	0	0	2	8			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr11:55433179G>T	uc001nht.3	+	3	802	c.537G>T	c.(535-537)TTG>TTT	p.L179F	OR4C6_uc010rik.1_Missense_Mutation_p.L179F	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TATGTGATTTGTTTCAGTTGT	0.433													50	63					3.68337e-26	4.24146e-26	1	0	T	55433179	T	T	55433179	3	4	304	1	0	0	0	0	1	0	0	0	11106	1368	48	4	539	4	OR4C6	11	55433179	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	33160803	55433179	79573337	75	56362											
TNKS1BP1	85456	broad.mit.edu	37	chr11	57088123	57088123	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcaggctgggtttggcaggcAgggctggcttggcaggcagg	5	7	21	8	0	0	0	0	0	0	0	0	0	0	0	0	9	0	9	0	9	0	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr11:57088123A>C	uc001njr.2	-	2	470	c.158T>G	c.(157-159)CTG>CGG	p.L53R	TNKS1BP1_uc001njs.2_Missense_Mutation_p.L53R|TNKS1BP1_uc009ymd.1_5'UTR	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	53	Arg/Glu/Lys/Pro-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				TTTGGCAGGCAGGGCTGGCTT	0.647													5	26					0	0	0	0	C	57088123	C	C	57088123	3	2	304	1	0	0	0	0	1	0	0	0	16386	188	7	5	5067	5	TNKS1BP1	11	57088123	Missense_Mutation	SNP	A	TCGA-IQ-7630-01A-11D-2078-08	1654944	57088123	77918393	76	56363											
SHANK2	22941	broad.mit.edu	37	chr11	70332944	70332944	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	cacgaaatggttttcgggctCcctgggcgtggcactcggca	6	9	14	12	4	0	0	0	0	0	0	3	1	1	0	1	5	0	4	1	5	1	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr11:70332944C>T	uc001oqc.2	-	21	3532	c.3454G>A	c.(3454-3456)GAG>AAG	p.E1152K	SHANK2_uc010rqn.1_Missense_Mutation_p.E564K|SHANK2_uc001opz.2_Missense_Mutation_p.E557K|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	773					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTTTCGGGCTCCCTGGGCGTG	0.677													21	50					0	0	0	0	T	70332944	T	T	70332944	3	4	304	1	0	0	0	0	1	0	0	0	14330	864	30	2	2103	2	SHANK2	11	70332944	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	13244821	70332944	64673572	77	56364											
NUMA1	4926	broad.mit.edu	37	chr11	71721849	71721849	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	caccttcagcttctgctgctGcaccttgctggcttggtcag	4	13	10	14	0	3	0	2	0	1	0	3	0	3	0	2	2	5	6	2	2	0	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr11:71721849G>A	uc001orl.1	-	17	4874	c.4702C>T	c.(4702-4704)CAG>TAG	p.Q1568*	NUMA1_uc001orj.2_5'Flank|NUMA1_uc009ysw.1_Nonsense_Mutation_p.Q1117*|NUMA1_uc001ork.1_Nonsense_Mutation_p.Q432*|NUMA1_uc001orm.1_Nonsense_Mutation_p.Q1554*|NUMA1_uc001orn.2_Nonsense_Mutation_p.Q1131*	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1568	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						TTCTGCTGCTGCACCTTGCTG	0.592			T	RARA	APL								67	221					0	0	0	0	A	71721849	A	A	71721849	4	1	304	1	0	0	0	0	0	1	0	0	10804	1328	46	4	1689	4	NUMA1	11	71721849	Nonsense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	1388905	71721849	63284667	78	56365											
KCNJ5	3762	broad.mit.edu	37	chr11	128781352	128781352	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaagagtggcaagtgcaacGtgcaccacggcaacgtccag	13	4	13	11	3	0	2	0	0	0	2	1	2	1	2	2	2	4	4	2	2	4	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr11:128781352G>A	uc001qet.2	+	2	498	c.184G>A	c.(184-186)GTG>ATG	p.V62M	KCNJ5_uc009zck.2_Missense_Mutation_p.V62M|KCNJ5_uc001qew.2_Missense_Mutation_p.V62M	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	62	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CAAGTGCAACGTGCACCACGG	0.607													28	66					0	0	0	0	A	128781352	A	A	128781352	3	1	304	1	0	0	0	0	1	0	0	0	8093	1145	40	1	186	1	KCNJ5	11	128781352	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	57059503	128781352	6225164	79	56366											
CACNA1C	775	broad.mit.edu	37	chr12	2566851	2566851	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tccgcgtgctgcgccccctgCggctggtgtccggagtccca	2	8	14	17	5	0	0	0	0	0	0	3	1	3	1	5	3	3	2	5	3	0	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr12:2566851C>T	uc009zdu.1	+	5	1049	c.736C>T	c.(736-738)CGG>TGG	p.R246W	CACNA1C_uc009zdv.1_Missense_Mutation_p.R246W|CACNA1C_uc001qkb.2_Missense_Mutation_p.R246W|CACNA1C_uc001qkc.2_Missense_Mutation_p.R246W|CACNA1C_uc001qke.2_Missense_Mutation_p.R246W|CACNA1C_uc001qkf.2_Missense_Mutation_p.R246W|CACNA1C_uc001qjz.2_Missense_Mutation_p.R246W|CACNA1C_uc001qkd.2_Missense_Mutation_p.R246W|CACNA1C_uc001qkg.2_Missense_Mutation_p.R246W|CACNA1C_uc009zdw.1_Missense_Mutation_p.R246W|CACNA1C_uc001qkh.2_Missense_Mutation_p.R246W|CACNA1C_uc001qkl.2_Missense_Mutation_p.R246W|CACNA1C_uc001qkn.2_Missense_Mutation_p.R246W|CACNA1C_uc001qko.2_Missense_Mutation_p.R246W|CACNA1C_uc001qkp.2_Missense_Mutation_p.R246W|CACNA1C_uc001qkr.2_Missense_Mutation_p.R246W|CACNA1C_uc001qku.2_Missense_Mutation_p.R246W|CACNA1C_uc001qkq.2_Missense_Mutation_p.R246W|CACNA1C_uc001qks.2_Missense_Mutation_p.R246W|CACNA1C_uc001qkt.2_Missense_Mutation_p.R246W|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_5'UTR|CACNA1C_uc001qkj.1_5'UTR|CACNA1C_uc001qkk.1_5'UTR|CACNA1C_uc001qkm.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	246	I.|Helical; Name=S4 of repeat I; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCGCCCCCTGCGGCTGGTGTC	0.567													71	187					0	0	0	0	T	2566851	T	T	2566851	3	4	304	1	0	0	0	0	1	0	0	0	2552	759	27	1	754	1	CACNA1C	12	2566851	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		2566851	131285044	80	56367											
DYRK4	8798	broad.mit.edu	37	chr12	4705363	4705363	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	atgaagttctggagacaatcGggaaggggtcctttggacag	11	9	15	6	1	1	2	0	1	1	1	3	5	2	4	1	5	0	1	1	5	3	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr12:4705363G>A	uc001qmx.2	+	5	491	c.331G>A	c.(331-333)GGG>AGG	p.G111R	DYRK4_uc009zeh.1_Missense_Mutation_p.G226R|DYRK4_uc001qmy.1_Missense_Mutation_p.G111R	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	111	ATP (By similarity).|Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			GGAGACAATCGGGAAGGGGTC	0.542													49	85					0	0	0	0	A	4705363	A	A	4705363	3	1	304	1	0	0	0	0	1	0	0	0	4880	1116	39	1	341	1	DYRK4	12	4705363	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	2138512	4705363	129146532	81	56368											
MLF2	8079	broad.mit.edu	37	chr12	6857986	6857986	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agtcatagcggcgggactgtCgggaaggggagtcctcaggt	8	7	18	8	3	2	0	2	0	0	0	4	3	3	3	1	6	1	0	1	6	2	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr12:6857986C>T	uc010sfi.1	-	8	785	c.722G>A	c.(721-723)CGA>CAA	p.R241Q	MLF2_uc001qqp.2_Missense_Mutation_p.R241Q|MLF2_uc009zey.1_Missense_Mutation_p.R241Q	NM_005439	NP_005430	Q15773	MLF2_HUMAN	myeloid leukemia factor 2	241					defense response	cytoplasm|nucleus	protein binding			large_intestine(1)	1						GCGGGACTGTCGGGAAGGGGA	0.687													7	81					0	0	0	0	T	6857986	T	T	6857986	3	4	304	1	0	0	0	0	1	0	0	0	9669	884	31	1	28	1	MLF2	12	6857986	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	2152623	6857986	126993909	82	56369											
TENC1	23371	broad.mit.edu	37	chr12	53450797	53450797	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	actggccttgctatccccagGgcggaccaggcactggccac	7	6	12	16	1	0	0	0	0	0	0	1	1	1	1	5	5	1	2	5	5	1	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr12:53450797G>A	uc001sbp.2	+	11	897	c.762G>A	c.(760-762)GGG>GGA	p.G254G	uc001sbk.1_5'Flank|TENC1_uc001sbl.2_Silent_p.G130G|TENC1_uc001sbn.2_Silent_p.G264G|TENC1_uc001sbo.1_Silent_p.G254G|TENC1_uc001sbq.2_5'Flank|TENC1_uc001sbr.2_5'Flank|TENC1_uc009zmr.2_5'Flank	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	254	Phosphatase tensin-type.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						CTATCCCCAGGGCGGACCAGG	0.577													3	16					0	0	0	0	A	53450797	A	A	53450797	2	1	304	1	0	0	0	0	0	0	0	1	15824	1246	43	4		4	TENC1	12	53450797	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	46592811	53450797	80401098	83	56370											
SMUG1	23583	broad.mit.edu	37	chr12	54576249	54576249	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aagacctcaggctgtccacaGaggttccggaaaaagcccca	13	5	10	13	1	1	2	1	0	0	2	3	3	3	3	5	3	1	2	5	3	3	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr12:54576249G>A	uc001sff.1	-	4	573	c.444C>T	c.(442-444)CTC>CTT	p.L148L	SMUG1_uc001sfa.1_5'Flank|SMUG1_uc001sfe.1_3'UTR|SMUG1_uc001sfg.1_Silent_p.L148L|SMUG1_uc009znf.1_Silent_p.L148L|SMUG1_uc001sfb.3_Intron|SMUG1_uc001sfc.3_Intron|SMUG1_uc001sfd.3_Intron	NM_014311	NP_055126	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional	148				Missing (in Ref. 3; BAC03670).	depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity				0						GCTGTCCACAGAGGTTCCGGA	0.567								BER_DNA_glycosylases					26	70					0	0	0	0	A	54576249	A	A	54576249	2	1	304	1	0	0	0	0	0	0	0	1	14882	929	33	2		2	SMUG1	12	54576249	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	1125452	54576249	79275646	84	56371											
CDK4	1019	broad.mit.edu	37	chr12	58143283	58143283	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	ttcagagtttccacagaagaGaggcctaaggtgagaaggga	14	7	14	6	0	1	4	1	1	0	4	2	7	2	5	2	3	0	1	2	3	3	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr12:58143283G>A	uc001spv.2	-	6	864	c.637C>T	c.(637-639)CTC>TTC	p.L213F	CDK4_uc010ssb.1_Missense_Mutation_p.L93F|CDK4_uc001spw.2_RNA|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	213	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CCACAGAAGAGAGGCCTAAGG	0.403			Mis			melanoma 			Hereditary_Melanoma				7	21					0	0	0	0	A	58143283	A	A	58143283	3	1	304	1	0	0	0	0	1	0	0	0	3156	942	33	2	286	2	CDK4	12	58143283	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	3567034	58143283	75708612	85	56372											
NAV3	89795	broad.mit.edu	37	chr12	78583919	78583919	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atttggcaaacaaacttgctGaatatgtaataaccaaatct	17	12	5	7	0	1	1	0	1	1	0	1	1	1	1	1	1	4	3	1	1	7	5			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr12:78583919G>A	uc001syp.2	+	34	6384	c.6211G>A	c.(6211-6213)GAA>AAA	p.E2071K	NAV3_uc001syo.2_Missense_Mutation_p.E2049K|NAV3_uc010sub.1_Missense_Mutation_p.E1528K|NAV3_uc009zsf.2_Missense_Mutation_p.E880K	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2071						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CAAACTTGCTGAATATGTAAT	0.373										HNSCC(70;0.22)			10	40					0	0	0	0	A	78583919	A	A	78583919	3	1	304	1	0	0	0	0	1	0	0	0	10238	1291	45	2	6275	2	NAV3	12	78583919	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	20440636	78583919	55267976	86	56373											
HCFC2	29915	broad.mit.edu	37	chr12	104496888	104496888	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatttattgtggtcttaagaCatcatgtatagtaactgctg	11	16	9	5	0	2	1	1	0	1	1	2	2	2	1	0	1	2	3	0	1	5	7			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr12:104496888C>T	uc001tkj.3	+	15	2319	c.2216C>T	c.(2215-2217)ACA>ATA	p.T739I	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	739	Fibronectin type-III 3.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						GGTCTTAAGACATCATGTATA	0.388													6	105					0	0	0	0	T	104496888	T	T	104496888	3	4	304	1	0	0	0	0	1	0	0	0	7032	478	17	4	2274	4	HCFC2	12	104496888	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	25912969	104496888	29355007	87	56374											
FLT1	2321	broad.mit.edu	37	chr13	29002024	29002024	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gccacgagtcaaatagcgagCagatttctcagtcgcaggta	12	8	11	10	3	2	1	2	0	1	1	4	3	2	1	1	1	2	3	1	1	3	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr13:29002024C>T	uc001usb.3	-	9	1426	c.1141G>A	c.(1141-1143)GCT>ACT	p.A381T	FLT1_uc010aar.1_Missense_Mutation_p.A381T|FLT1_uc001usc.3_Missense_Mutation_p.A381T|FLT1_uc010tdp.1_Missense_Mutation_p.A381T	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	381	Ig-like C2-type 4.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AAATAGCGAGCAGATTTCTCA	0.403													13	54					0	0	0	0	T	29002024	T	T	29002024	3	4	304	1	0	0	0	0	1	0	0	0	5973	710	25	4	3226	4	FLT1	13	29002024	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		29002024	86167854	88	56375											
SLC15A1	6564	broad.mit.edu	37	chr13	99378415	99378415	+	Silent	SNP	G	A	A																															gagtcggcgataagagctccGagaattggcgtcaggtagca																										TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr13:99378415G>A	uc001vno.2	-	4	284	c.207C>T	c.(205-207)CTC>CTT	p.L69L	SLC15A1_uc001vnp.1_Silent_p.L37L	NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	69	Helical; (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	TAAGAGCTCCGAGAATTGGCG	0.453													12	31					0	0	0	0	A	99378415	A	A	99378415	2	1	304	1	0	0	0	0	0	0	0	1	14463	1045	37	1		1	SLC15A1	13	99378415	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	70376391	99378415	15791463	89	56376	135	2									
SLC15A1	6564	broad.mit.edu	37	chr13	99378417	99378417	+	Missense_Mutation	SNP	G	C	C																															gtcggcgataagagctccgaGaattggcgtcaggtagcaca																								rs140055365		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr13:99378417G>C	uc001vno.2	-	4	282	c.205C>G	c.(205-207)CTC>GTC	p.L69V	SLC15A1_uc001vnp.1_Missense_Mutation_p.L37V	NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	69	Helical; (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	AGAGCTCCGAGAATTGGCGTC	0.453													12	32					0	0	0	0	C	99378417	C	C	99378417	3	2	304	1	0	0	0	0	1	0	0	0	14463	942	33	2	2001	2	SLC15A1	13	99378417	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	2	99378417	15791461	90	56377	135	2									
FAM158A	51016	broad.mit.edu	37	chr14	24608771	24608771	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	caccataataagtactgcatCagggaagaattctgcaattc	15	10	7	9	0	2	1	1	0	1	1	3	2	2	2	1	1	3	3	1	1	6	5			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:24608771C>A	uc001wmi.2	-	4	491	c.328G>T	c.(328-330)GAT>TAT	p.D110Y		NM_016049	NP_057133	Q9Y3B6	F158A_HUMAN	hypothetical protein LOC51016	110											0						AGTACTGCATCAGGGAAGAAT	0.527													8	24					0.000442599	0.000464607	1	0	A	24608771	A	A	24608771	3	1	304	1	0	0	0	0	1	0	0	0	5495	826	29	2	310	2	FAM158A	14	24608771	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		24608771	82740769	91	56378											
MIA2	117153	broad.mit.edu	37	chr14	39716136	39716136	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	aatctgactttctttgtcttCttggagtaagttacacattt	9	19	6	7	0	4	1	0	1	4	0	4	2	4	2	0	1	1	2	0	1	3	7			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:39716136C>T	uc001wux.2	+	4	552	c.358C>T	c.(358-360)CTT>TTT	p.L120F	MIA2_uc010amy.1_Missense_Mutation_p.L51F	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	120						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		TCTTTGTCTTCTTGGAGTAAG	0.294													5	19					0	0	0	0	T	39716136	T	T	39716136	3	4	304	1	0	0	0	0	1	0	0	0	9617	913	32	2	372	2	MIA2	14	39716136	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	15107365	39716136	67633404	92	56379											
SDCCAG1	9147	broad.mit.edu	37	chr14	50318366	50318366	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgccagattcaagtaaaagtGtagctttaaagtccggtctg	12	12	10	7	1	2	1	1	0	1	1	3	1	3	1	2	1	2	3	2	1	6	5			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:50318366G>T	uc001wxc.2	-	3	214	c.146C>A	c.(145-147)ACA>AAA	p.T49K	SDCCAG1_uc010anj.1_Missense_Mutation_p.T49K|SDCCAG1_uc010tqi.1_Missense_Mutation_p.T49K|SDCCAG1_uc001wxe.2_Missense_Mutation_p.T49K|SDCCAG1_uc010anq.1_5'UTR	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	49						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		AAGTAAAAGTGTAGCTTTAAA	0.353													4	59					0.000602214	0.000628685	1	0	T	50318366	T	T	50318366	3	4	304	1	0	0	0	0	1	0	0	0	14022	1377	48	4	3208	4	SDCCAG1	14	50318366	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	10602230	50318366	57031174	93	56380											
SYNE2	23224	broad.mit.edu	37	chr14	64565540	64565540	+	Splice_Site	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aaagttccgtgaagagcgatGtaagggaaatgattttcttg	13	12	12	4	2	1	3	0	2	1	1	2	5	2	4	1	1	1	2	1	1	4	5			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:64565540G>A	uc001xgm.2	+	63	12611	c.12381_splice	c.e63+1	p.D4127_splice	SYNE2_uc001xgl.2_Splice_Site_p.D4127_splice|SYNE2_uc010apy.2_Splice_Site_p.D512_splice|SYNE2_uc010apx.1_Missense_Mutation_p.V520I|SYNE2_uc010apz.1_Splice_Site_p.D19_splice	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2						centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAAGAGCGATGTAAGGGAAAT	0.388													5	19					0	0	0	0	A	64565540	A	A	64565540	5	1	304	1	0	0	0	0	0	0	1	0	15512	1391	48	4	12628	4	SYNE2	14	64565540	Splice_Site	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	14247174	64565540	42784000	94	56381											
MAP3K9	4293	broad.mit.edu	37	chr14	71209185	71209185	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctggtggatgatgatgttgaGctcccgttccaggatgtcaa	8	12	13	8	1	1	3	1	3	0	0	3	5	3	5	2	3	1	3	2	3	1	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:71209185G>A	uc001xmm.2	-	6	1450	c.1450C>T	c.(1450-1452)CTC>TTC	p.L484F	MAP3K9_uc010ttk.1_Missense_Mutation_p.L221F|MAP3K9_uc001xmk.2_Missense_Mutation_p.L178F|MAP3K9_uc001xml.2_Missense_Mutation_p.L484F	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	484	Leucine-zipper 2.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		ATGATGTTGAGCTCCCGTTCC	0.617													14	35					0	0	0	0	A	71209185	A	A	71209185	3	1	304	1	0	0	0	0	1	0	0	0	9310	971	34	4	1938	4	MAP3K9	14	71209185	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	6643645	71209185	36140355	95	56382											
PAPLN	89932	broad.mit.edu	37	chr14	73720589	73720589	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tggaggaggctgagtgtgccGggctgcctgggaagccccct	5	7	18	11	1	0	1	0	1	0	0	0	4	0	4	4	5	3	2	4	5	1	0	rs145657526	byFrequency	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:73720589G>T	uc010ttx.1	+	11	1385	c.1222G>T	c.(1222-1224)GGG>TGG	p.G408W	PAPLN_uc001xnw.3_Missense_Mutation_p.G381W|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.G408W	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	408	TSP type-1 3.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		TGAGTGTGCCGGGCTGCCTGG	0.697													14	39					1.05317e-09	1.17019e-09	1	0	T	73720589	T	T	73720589	3	4	304	1	0	0	0	0	1	0	0	0	11482	1116	39	3	1179	3	PAPLN	14	73720589	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	2511404	73720589	33628951	96	56383											
PTGR2	145482	broad.mit.edu	37	chr14	74345930	74345930	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	gacaatgtggcagaacagctCcgtgaatcatgcccagctgg	11	7	12	11	1	1	2	1	1	0	1	2	3	2	2	2	2	4	3	2	2	3	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:74345930C>A	uc001xow.2	+	6	811	c.651C>A	c.(649-651)CTC>CTA	p.L217L	PTGR2_uc010tue.1_Silent_p.L217L|PTGR2_uc001xox.2_Silent_p.L217L|ZNF410_uc001xoy.1_Intron	NM_001146154	NP_001139626	Q8N8N7	PTGR2_HUMAN	prostaglandin reductase 2	217					prostaglandin metabolic process		15-oxoprostaglandin 13-oxidase activity|zinc ion binding				0						CAGAACAGCTCCGTGAATCAT	0.403													45	112					4.06502e-11	4.57014e-11	1	0	A	74345930	A	A	74345930	2	1	304	1	0	0	0	0	0	0	0	1	12817	842	30	2		2	PTGR2	14	74345930	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	625341	74345930	33003610	97	56384											
C14orf148	122945	broad.mit.edu	37	chr14	77872373	77872373	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gcacggagagaaagagttcaCtcagaagctgcagcacttgg	13	6	13	9	1	2	3	2	0	0	3	2	5	2	4	0	2	3	5	0	2	2	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:77872373C>G	uc001xtr.2	-	5	935	c.788G>C	c.(787-789)AGT>ACT	p.S263T		NM_001113475	NP_001106946	Q6NXP6	CN148_HUMAN	hypothetical protein LOC122945 isoform 1	263					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		AAAGAGTTCACTCAGAAGCTG	0.463													7	25					0	0	0	0	G	77872373	G	G	77872373	3	3	304	1	0	0	0	0	1	0	0	0	1757	565	20	4	299	4	C14orf148	14	77872373	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	3526443	77872373	29477167	98	56385											
TDP1	55775	broad.mit.edu	37	chr14	90485752	90485752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gctcggggtccttttcctccCttcagcatttgtaagtttac	5	16	8	12	1	1	0	1	0	0	0	5	0	4	0	3	2	2	4	3	2	2	7			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:90485752C>T	uc001xxy.2	+	15	1933	c.1634C>T	c.(1633-1635)CCT>CTT	p.P545L	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.P545L|TDP1_uc010atn.2_Missense_Mutation_p.P545L|TDP1_uc001xya.2_Missense_Mutation_p.P306L|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.P545L|TDP1_uc001xyd.1_Missense_Mutation_p.P160L	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	545					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		CTTTTCCTCCCTTCAGCATTT	0.512								Repair_of_DNA-protein_crosslinks					7	15					0	0	0	0	T	90485752	T	T	90485752	3	4	304	1	0	0	0	0	1	0	0	0	15794	681	24	4	1684	4	TDP1	14	90485752	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	12613379	90485752	16863788	99	56386											
FBLN5	10516	broad.mit.edu	37	chr14	92347671	92347671	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	agataaggctcctcacagcgGatggggtcaatgcatttgaa	12	9	12	8	1	2	2	2	1	0	1	3	3	3	3	1	4	2	2	1	4	3	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:92347671G>A	uc001xzx.3	-	9	1427	c.954C>T	c.(952-954)ATC>ATT	p.I318I	FBLN5_uc010aud.2_Silent_p.I323I|FBLN5_uc010aue.2_Silent_p.I359I	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	318	EGF-like 6; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				CCTCACAGCGGATGGGGTCAA	0.527													11	35					0	0	0	0	A	92347671	A	A	92347671	2	1	304	1	0	0	0	0	0	0	0	1	5732	1164	41	2		2	FBLN5	14	92347671	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	1861919	92347671	15001869	100	56387											
FBLN5	10516	broad.mit.edu	37	chr14	92357591	92357591	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagaccttccatcctcattgAgggtaaaaccagggttgcat	12	10	9	10	0	1	2	1	1	0	1	3	2	3	2	4	2	2	3	4	2	3	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:92357591A>G	uc001xzx.3	-	6	1066	c.593T>C	c.(592-594)CTC>CCC	p.L198P	FBLN5_uc010aud.2_Missense_Mutation_p.L203P|FBLN5_uc010aue.2_Missense_Mutation_p.L239P	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	198	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				ATCCTCATTGAGGGTAAAACC	0.478													3	45					0	0	0	0	G	92357591	G	G	92357591	3	3	304	1	0	0	0	0	1	0	0	0	5732	304	11	5	777	5	FBLN5	14	92357591	Missense_Mutation	SNP	A	TCGA-IQ-7630-01A-11D-2078-08	9920	92357591	14991949	101	56388											
C14orf177	283598	broad.mit.edu	37	chr14	99182522	99182522	+	Translation_Start_Site	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ggaatcaattgcttccagtaCgactggatgcatcggaaaga	13	9	11	8	2	1	1	1	0	0	1	3	5	2	4	1	3	3	3	1	3	4	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:99182522C>T	uc001yfz.1	+	3	413	c.-6C>T	c.(-8--4)TACGA>TATGA			NM_182560	NP_872366	Q52M58	CN177_HUMAN	hypothetical protein LOC283598												0		Melanoma(154;0.128)				GCTTCCAGTACGACTGGATGC	0.572													8	13					0	0	0	0	T	99182522	T	T	99182522	1	4	304	1	0	0	0	0	0	0	0	0	1766	551	19	1		1	C14orf177	14	99182522	Translation_Start_Site	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	6824931	99182522	8167018	102	56389											
GPR132	29933	broad.mit.edu	37	chr14	105518369	105518369	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ctgctctcttcgaaggacacGttgttgcaggtcttggcgga	6	12	13	10	3	2	0	0	0	2	0	4	3	2	2	0	4	2	4	0	4	1	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr14:105518369G>A	uc001yqd.2	-	4	1004	c.105C>T	c.(103-105)AAC>AAT	p.N35N	GPR132_uc001yqc.2_Translation_Start_Site|GPR132_uc001yqe.2_Silent_p.N26N	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	35	Extracellular (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		CGAAGGACACGTTGTTGCAGG	0.657													17	50					0	0	0	0	A	105518369	A	A	105518369	2	1	304	1	0	0	0	0	0	0	0	1	6680	1136	40	1		1	GPR132	14	105518369	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	6335847	105518369	1831171	103	56390											
PLA2G4F	255189	broad.mit.edu	37	chr15	42434752	42434752	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccaggtgtgtgcggaaggtaCggttaaccagggggaagtgc	9	7	18	7	2	0	0	0	0	0	0	0	2	0	2	2	6	4	2	2	6	4	2	rs138996971		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr15:42434752C>T	uc001zoz.2	-	19	2366	c.2303G>A	c.(2302-2304)CGT>CAT	p.R768H	PLA2G4F_uc010bcq.2_Missense_Mutation_p.R65H|PLA2G4F_uc001zoy.2_Missense_Mutation_p.R400H|PLA2G4F_uc010bcr.2_Missense_Mutation_p.R519H|PLA2G4F_uc001zpa.2_Missense_Mutation_p.R519H|PLA2G4F_uc010bcs.2_Missense_Mutation_p.R555H	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	768	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GCGGAAGGTACGGTTAACCAG	0.637													12	50					0	0	0	0	T	42434752	T	T	42434752	3	4	304	1	0	0	0	0	1	0	0	0	12061	536	19	1	254	1	PLA2G4F	15	42434752	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		42434752	60096640	104	56391											
MYO5A	4644	broad.mit.edu	37	chr15	52664414	52664414	+	Silent	SNP	G	C	C	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	actgagcgagcctcgattttGagcttctttagctcacgctt	7	14	9	11	3	2	2	1	2	1	0	3	4	2	2	1	0	4	3	1	0	1	6			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr15:52664414G>C	uc002aby.2	-	21	2968	c.2724C>G	c.(2722-2724)CTC>CTG	p.L908L	MYO5A_uc002abx.3_Silent_p.L908L|MYO5A_uc010uge.1_Silent_p.L777L	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	908	IQ 6.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CCTCGATTTTGAGCTTCTTTA	0.537													11	25					0	0	0	0	C	52664414	C	C	52664414	2	2	304	1	0	0	0	0	0	0	0	1	10131	1277	45	2		2	MYO5A	15	52664414	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	10229662	52664414	49866978	105	56392											
PARP16	54956	broad.mit.edu	37	chr15	65555626	65555626	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	agggccaggctcaagtcactGgtgaggtaggtcccctctcc	7	8	13	13	0	3	1	2	1	1	0	5	1	4	1	4	5	0	2	4	5	2	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr15:65555626G>A	uc002aoo.2	-	4	806	c.552C>T	c.(550-552)ACC>ACT	p.T184T	PARP16_uc002aop.2_Silent_p.T69T|PARP16_uc002aoq.2_Silent_p.T184T	NM_017851	NP_060321	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	184	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			lung(2)	2						TCAAGTCACTGGTGAGGTAGG	0.567													4	18					0	0	0	0	A	65555626	A	A	65555626	2	1	304	1	0	0	0	0	0	0	0	1	11514	1335	47	4		4	PARP16	15	65555626	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	12891212	65555626	36975766	106	56393											
EFTUD1	79631	broad.mit.edu	37	chr15	82512532	82512532	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatgcctttgtcttgcaCgctcacgtctctgagcaatt	6	14	8	13	2	3	1	1	1	2	0	4	1	3	1	1	0	4	4	1	0	1	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr15:82512532C>T	uc002bgt.1	-	13	1500	c.1331G>A	c.(1330-1332)CGT>CAT	p.R444H	EFTUD1_uc002bgu.1_Missense_Mutation_p.R393H	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	444					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						TTGTCTTGCACGCTCACGTCT	0.498													45	144					0	0	0	0	T	82512532	T	T	82512532	3	4	304	1	0	0	0	0	1	0	0	0	4982	536	19	1	2063	1	EFTUD1	15	82512532	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	16956906	82512532	20018860	107	56394											
UMOD	7369	broad.mit.edu	37	chr16	20348717	20348717	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	catctggacggaaaatcggcCctgggaggactccccattct	9	8	11	13	2	2	0	0	0	2	0	4	4	3	4	3	5	0	0	3	5	2	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr16:20348717C>A	uc002dgz.2	-	8	1765	c.1636G>T	c.(1636-1638)GGC>TGC	p.G546C	UMOD_uc002dha.2_Missense_Mutation_p.G546C|UMOD_uc002dhb.2_Missense_Mutation_p.G579C	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	546	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						GAAAATCGGCCCTGGGAGGAC	0.453													14	29					7.93312e-07	8.6131e-07	1	0	A	20348717	A	A	20348717	3	1	304	1	0	0	0	0	1	0	0	0	17047	623	22	4	302	4	UMOD	16	20348717	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		20348717	70006036	108	56395											
SLC12A4	6560	broad.mit.edu	37	chr16	67979117	67979117	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	tgcatgcgccgcacattggaTtggtccctacacgtagtgta	8	11	11	11	3	0	0	0	0	0	0	1	1	1	1	2	2	3	4	2	2	3	5	rs150617520		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr16:67979117T>C	uc002euz.2	-	23	3180	c.3039A>G	c.(3037-3039)CAA>CAG	p.Q1013Q	LCAT_uc002euy.1_5'Flank|SLC12A4_uc010ceu.2_Silent_p.Q1007Q|SLC12A4_uc010vkh.1_Silent_p.Q982Q|SLC12A4_uc010vki.1_Silent_p.Q1007Q|SLC12A4_uc010vkj.1_Silent_p.Q1015Q|SLC12A4_uc002eva.2_Silent_p.Q1013Q	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	1013	Cytoplasmic (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCACATTGGATTGGTCCCTAC	0.592													14	49					0	0	0	0	C	67979117	C	C	67979117	2	2	304	1	0	0	0	0	0	0	0	1	14450	1490	52	5		5	SLC12A4	16	67979117	Silent	SNP	T	TCGA-IQ-7630-01A-11D-2078-08	47630400	67979117	22375636	109	56396											
ZNF23	7571	broad.mit.edu	37	chr16	71482652	71482652	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	gttacatctgaaggctttccCgcattcattacactcatagg	10	13	7	11	1	3	1	2	1	1	0	4	1	4	1	1	2	2	3	1	2	4	5			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr16:71482652C>T	uc002faf.2	-	6	2090	c.1276G>A	c.(1276-1278)GGG>AGG	p.G426R	ZNF23_uc002fad.2_Missense_Mutation_p.G368R|ZNF23_uc002fae.2_Missense_Mutation_p.G368R|ZNF23_uc010vmf.1_Missense_Mutation_p.G368R|ZNF23_uc002fag.2_Missense_Mutation_p.G368R|ZNF23_uc002fah.2_Missense_Mutation_p.G426R|ZNF23_uc002fai.2_Missense_Mutation_p.G465R	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	426	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		AAGGCTTTCCCGCATTCATTA	0.463													8	30					0	0	0	0	T	71482652	T	T	71482652	3	4	304	1	0	0	0	0	1	0	0	0	17850	652	23	1	659	1	ZNF23	16	71482652	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	3503535	71482652	18872101	110	56397											
SLC16A13	201232	broad.mit.edu	37	chr17	6942181	6942181	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgcagatgatagagagcatcGgggggctgctggggcctcct	7	8	17	9	1	0	3	0	1	0	2	2	4	1	3	2	5	3	4	2	5	1	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr17:6942181G>A	uc002geh.2	+	3	1362	c.1054G>A	c.(1054-1056)GGG>AGG	p.G352R		NM_201566	NP_963860	Q7RTY0	MOT13_HUMAN	monocarboxylate transporter 13	352	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(1)|skin(1)	2						AGAGAGCATCGGGGGGCTGCT	0.463													29	97					0	0	0	0	A	6942181	A	A	6942181	3	1	304	1	0	0	0	0	1	0	0	0	14471	1116	39	1	1064	1	SLC16A13	17	6942181	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08		6942181	74253029	111	56398											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T																															tgatggtgaggatgggcctcCggttcatgccgcccatgcag																								rs11540652		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	35					0	0	0	0	T	7577538	T	T	7577538	3	4	304	1	0	0	0	0	1	0	0	0	16448	652	23	1	547	1	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	635357	7577538	73617672	112	56399	136	2									
TP53	7157	broad.mit.edu	37	chr17	7577548	7577548	+	Missense_Mutation	SNP	C	T	T																															gatgggcctccggttcatgcCgcccatgcaggaactgttac																								rs28934575		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	28					0	0	0	0	T	7577548	T	T	7577548	3	4	304	1	0	0	0	0	1	0	0	0	16448	652	23	1	557	1	TP53	17	7577548	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	10	7577548	73617662	113	56400	136	2									
CHD3	1107	broad.mit.edu	37	chr17	7800529	7800529	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	aagcgtaaagtgaaagacccGcactatgctgagatggagga	15	6	13	7	2	0	3	0	2	0	2	0	6	0	5	1	2	2	3	1	2	5	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr17:7800529G>A	uc002gje.2	+	11	1986	c.1836G>A	c.(1834-1836)CCG>CCA	p.P612P	CHD3_uc002gjd.2_Silent_p.P671P|CHD3_uc002gjf.2_Silent_p.P612P|CHD3_uc002gjg.1_Silent_p.P440P	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	612					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TGAAAGACCCGCACTATGCTG	0.542													17	45					0	0	0	0	A	7800529	A	A	7800529	2	1	304	1	0	0	0	0	0	0	0	1	3341	1074	38	1		1	CHD3	17	7800529	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	222981	7800529	73394681	114	56401											
KRT14	3861	broad.mit.edu	37	chr17	39740519	39740521	+	In_Frame_Del	DEL	TTC	-	-																															tagttctcacctcctcgtggTtcttcttcaggtaggccagc																										TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr17:39740519_39740521delTTC	uc002hxf.1	-	3	814_816	c.753_755delGAA	c.(751-756)AAGAAC>AAC	p.K251del	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_In_Frame_Del_p.K251del	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	251	Coil 1B.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				CTCCTCGTGGTTCTTCTTCAGGT	0.414													---	---	---								-	39740521	-	-	39740519	7	5	304	1	0	1	0	1	0	0	0	0	8490	1725	60	0	687	0	KRT14	17	39740519	In_Frame_Del	DEL	TTC	TCGA-IQ-7630-01A-11D-2078-08	31939990	39740519	41454691	115	56402											
WNK4	65266	broad.mit.edu	37	chr17	40940718	40940718	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	1	0	1	1	0	ggtctcagaccagaatgacaGagtggttgagtgccagctac	11	8	13	9	0	1	5	1	2	1	3	2	5	1	5	2	2	3	2	2	2	2	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr17:40940718G>C	uc002ibj.2	+	11	2081	c.2060G>C	c.(2059-2061)AGA>ACA	p.R687T	WNK4_uc010wgx.1_Missense_Mutation_p.R351T|WNK4_uc002ibk.1_Missense_Mutation_p.R459T|WNK4_uc010wgy.1_Missense_Mutation_p.R31T	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	687					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CAGAATGACAGAGTGGTTGAG	0.532													13	37					0	0	0	0	C	40940718	C	C	40940718	3	2	304	1	0	0	0	0	1	0	0	0	17448	942	33	2	2102	2	WNK4	17	40940718	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	1200199	40940718	40254492	116	56403											
TBX21	30009	broad.mit.edu	37	chr17	45822604	45822604	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccagtgattcaggactgggcGaaggagactctaagaggagg	12	6	16	7	1	2	3	1	1	1	2	2	7	2	5	1	5	0	0	1	5	2	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr17:45822604G>A	uc002ilv.1	+	6	1691	c.1480G>A	c.(1480-1482)GAA>AAA	p.E494K		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	494					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						AGGACTGGGCGAAGGAGACTC	0.617													11	31					0	0	0	0	A	45822604	A	A	45822604	3	1	304	1	0	0	0	0	1	0	0	0	15723	1059	37	1	1502	1	TBX21	17	45822604	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	4881886	45822604	35372606	117	56404											
ICAM2	3384	broad.mit.edu	37	chr17	62080239	62080239	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	acgaacagggacagcaacacCgacaccaccgtgactatgat	15	4	9	13	3	0	2	0	2	0	0	0	5	0	3	3	1	3	1	3	1	3	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr17:62080239C>T	uc002jdu.3	-	4	928	c.696G>A	c.(694-696)TCG>TCA	p.S232S	C17orf72_uc002jdt.3_3'UTR|C17orf72_uc010wpu.1_3'UTR|C17orf72_uc010wpv.1_3'UTR|C17orf72_uc010wpw.1_3'UTR|ICAM2_uc002jdw.3_Silent_p.S232S|ICAM2_uc010ded.2_Silent_p.S232S|ICAM2_uc002jdx.3_Silent_p.S232S|ICAM2_uc002jdv.3_Silent_p.S232S	NM_000873	NP_000864	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2 precursor	232	Helical; (Potential).				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			ovary(1)	1						ACAGCAACACCGACACCACCG	0.612													3	16					0	0	0	0	T	62080239	T	T	62080239	2	4	304	1	0	0	0	0	0	0	0	1	7519	639	23	1		1	ICAM2	17	62080239	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	16257635	62080239	19114971	118	56405											
USH1G	124590	broad.mit.edu	37	chr17	72915913	72915913	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	cagccgaccccgcggcgctcCcaccccatccagacccccat	7	3	7	24	4	0	1	0	0	0	1	2	2	2	1	9	1	1	1	9	1	0	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr17:72915913C>T	uc002jme.1	-	2	1201	c.1018G>A	c.(1018-1020)GGA>AGA	p.G340R	USH1G_uc010wro.1_Missense_Mutation_p.G237R	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	340					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					CGCGGCGCTCCCACCCCATCC	0.687													18	82					0	0	0	0	T	72915913	T	T	72915913	3	4	304	1	0	0	0	0	1	0	0	0	17103	632	22	4	375	4	USH1G	17	72915913	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	10835674	72915913	8279297	119	56406											
SLC26A11	284129	broad.mit.edu	37	chr17	78211342	78211342	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acatgggagccgggctggccGtggtgcccctgatgggcctc	4	7	17	13	2	0	1	0	1	0	0	1	2	0	2	5	5	2	1	5	5	0	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr17:78211342G>A	uc002jyb.1	+	9	1203	c.934G>A	c.(934-936)GTG>ATG	p.V312M	SLC26A11_uc002jyc.1_Missense_Mutation_p.V312M|SLC26A11_uc002jyd.1_Missense_Mutation_p.V312M|SLC26A11_uc010dhv.1_Missense_Mutation_p.V312M	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	312	Helical; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CGGGCTGGCCGTGGTGCCCCT	0.642													7	11					0	0	0	0	A	78211342	A	A	78211342	3	1	304	1	0	0	0	0	1	0	0	0	14580	1145	40	1	960	1	SLC26A11	17	78211342	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	5295429	78211342	2983868	120	56407											
DOT1L	84444	broad.mit.edu	37	chr19	2210646	2210646	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctgaggaagagaaggcGggagcagccaccgtgaagaa	13	3	18	7	2	0	4	0	2	0	2	0	7	0	6	2	4	3	2	2	4	4	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:2210646G>A	uc002lvb.3	+	14	1179	c.1143G>A	c.(1141-1143)GCG>GCA	p.A381A	DOT1L_uc002lvc.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	381						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGAGAAGGCGGGAGCAGCCA	0.647													19	76					0	0	0	0	A	2210646	A	A	2210646	2	1	304	1	0	0	0	0	0	0	0	1	4731	1103	39	1		1	DOT1L	19	2210646	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08		2210646	56918337	121	56408											
DUS3L	56931	broad.mit.edu	37	chr19	5789493	5789493	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagggctttgtccaggcCgttgcggatggacgggggct	4	9	18	10	3	0	0	0	0	0	0	1	2	1	2	2	6	2	4	2	6	0	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:5789493C>T	uc002mdc.2	-	3	722	c.625G>A	c.(625-627)GGC>AGC	p.G209S	DUS3L_uc002mdd.2_Intron|DUS3L_uc010duk.2_5'UTR|DUS3L_uc010xiw.1_RNA	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	209					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0						TTGTCCAGGCCGTTGCGGATG	0.726													5	9					0	0	0	0	T	5789493	T	T	5789493	3	4	304	1	0	0	0	0	1	0	0	0	4829	652	23	1	1371	1	DUS3L	19	5789493	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	3578847	5789493	53339490	122	56409											
C3	718	broad.mit.edu	37	chr19	6685055	6685055	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gatacggtgggtgatcttggAgctgcggctgggcagttgga	6	10	19	6	2	1	1	0	1	1	0	1	4	1	3	0	6	3	4	0	6	1	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:6685055A>G	uc002mfm.2	-	30	3975	c.3913T>C	c.(3913-3915)TCC>CCC	p.S1305P	C3_uc002mfl.2_Missense_Mutation_p.S41P	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1305					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GTGATCTTGGAGCTGCGGCTG	0.582													3	52					0	0	0	0	G	6685055	G	G	6685055	3	3	304	1	0	0	0	0	1	0	0	0	2214	304	11	5	1126	5	C3	19	6685055	Missense_Mutation	SNP	A	TCGA-IQ-7630-01A-11D-2078-08	895562	6685055	52443928	123	56410											
RDH8	50700	broad.mit.edu	37	chr19	10124179	10124179	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agggaggggatcaacatggcCgctgcaccccggactgtgtt	8	7	15	11	2	1	0	1	0	0	0	1	3	1	3	3	5	2	3	3	5	1	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:10124179C>T	uc002mmr.2	+	1	255	c.6C>T	c.(4-6)GCC>GCT	p.A2A		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	2					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	TCAACATGGCCGCTGCACCCC	0.607													14	28					0	0	0	0	T	10124179	T	T	10124179	2	4	304	1	0	0	0	0	0	0	0	1	13261	639	23	1		1	RDH8	19	10124179	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	3439124	10124179	49004804	124	56411											
OR7A17	26333	broad.mit.edu	37	chr19	14992152	14992152	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	aaattctgaaatccctgtgtCattctctggttccatctttt	8	18	5	10	0	4	1	1	1	3	0	7	1	6	1	2	1	0	1	2	1	2	5			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:14992152C>G	uc010xob.1	-	1	16	c.16G>C	c.(16-18)GAC>CAC	p.D6H		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					ATCCCTGTGTCATTCTCTGGT	0.279													9	13					0	0	0	0	G	14992152	G	G	14992152	3	3	304	1	0	0	0	0	1	0	0	0	11269	826	29	2	915	2	OR7A17	19	14992152	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	4867973	14992152	44136831	125	56412											
LSR	51599	broad.mit.edu	37	chr19	35757379	35757379	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agctatgattcccatgggccCtgcctacaacgggtaccctg	8	9	10	14	1	0	1	0	1	0	0	1	1	1	1	4	2	5	2	4	2	4	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:35757379C>A	uc002nyl.2	+	6	1263	c.1040C>A	c.(1039-1041)CCT>CAT	p.P347H	LSR_uc002nym.2_Missense_Mutation_p.P328H|LSR_uc002nyn.2_Missense_Mutation_p.P279H|LSR_uc002nyo.2_Missense_Mutation_p.P328H|LSR_uc010xsr.1_Missense_Mutation_p.P239H|LSR_uc002nyp.2_Missense_Mutation_p.P310H|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	347	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCCATGGGCCCTGCCTACAAC	0.627													19	24					2.4624e-09	2.70437e-09	1	0	A	35757379	A	A	35757379	3	1	304	1	0	0	0	0	1	0	0	0	9114	681	24	4	1062	4	LSR	19	35757379	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	20765227	35757379	23371604	126	56413											
FBXO27	126433	broad.mit.edu	37	chr19	39521762	39521762	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	agacctgcttcttgcaacacCagctgggaatgcaggagaca	12	7	11	11	0	1	2	0	0	1	2	1	4	1	3	2	2	5	4	2	2	2	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:39521762C>T	uc002okh.2	-	4	561	c.479G>A	c.(478-480)TGG>TAG	p.W160*		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	160	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CTTGCAACACCAGCTGGGAAT	0.537													28	41					0	0	0	0	T	39521762	T	T	39521762	4	4	304	1	0	0	0	0	0	1	0	0	5769	595	21	4	384	4	FBXO27	19	39521762	Nonsense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	3764383	39521762	19607221	127	56414											
PLEKHG2	64857	broad.mit.edu	37	chr19	39905661	39905661	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cccccaccatggcctcccccCgaggttctgggagctccaca	6	6	9	20	1	1	0	0	0	1	0	3	2	3	1	8	3	1	2	8	3	0	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:39905661C>T	uc010xuz.1	+	3	464	c.139C>T	c.(139-141)CGA>TGA	p.R47*	PLEKHG2_uc010xuy.1_Intron|PLEKHG2_uc002olj.2_Nonsense_Mutation_p.R47*|PLEKHG2_uc010xva.1_5'Flank	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	47					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGCCTCCCCCCGAGGTTCTGG	0.652													4	3					0	0	0	0	T	39905661	T	T	39905661	4	4	304	1	0	0	0	0	0	1	0	0	12124	644	23	1	145	1	PLEKHG2	19	39905661	Nonsense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	383899	39905661	19223322	128	56415											
CADM4	199731	broad.mit.edu	37	chr19	44131798	44131798	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctggtccccagcactcaccaCgggtgccattgaagaagagg	10	6	12	13	1	1	3	1	1	0	2	2	3	2	3	4	3	2	1	4	3	2	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:44131798C>T	uc002oxc.1	-	2	258	c.209G>A	c.(208-210)CGT>CAT	p.R70H		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	70	Ig-like V-type.|Extracellular (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				GCACTCACCACGGGTGCCATT	0.378													21	68					0	0	0	0	T	44131798	T	T	44131798	3	4	304	1	0	0	0	0	1	0	0	0	2581	536	19	1	989	1	CADM4	19	44131798	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	4226137	44131798	14997185	129	56416											
HIF3A	64344	broad.mit.edu	37	chr19	46842835	46842835	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	acgaggacactacccagcccGggggccccttccagccaagg	9	3	12	17	2	0	0	0	0	0	0	1	2	1	1	6	4	3	0	6	4	2	2	rs143456536		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:46842835G>A	uc002peh.2	+	15	1995	c.1966G>A	c.(1966-1968)GGG>AGG	p.G656R	HIF3A_uc002pek.2_Missense_Mutation_p.G600R|HIF3A_uc010xxy.1_Missense_Mutation_p.G587R|HIF3A_uc002pel.2_Missense_Mutation_p.G654R	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	656					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		TACCCAGCCCGGGGGCCCCTT	0.577													15	74					0	0	0	0	A	46842835	A	A	46842835	3	1	304	1	0	0	0	0	1	0	0	0	7144	1116	39	1	2048	1	HIF3A	19	46842835	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	2711037	46842835	12286148	130	56417											
C5AR1	728	broad.mit.edu	37	chr19	47823721	47823721	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	actttcatcctgctccggacGtggagccgcagggccacgcg	6	7	13	15	5	1	0	1	0	0	0	3	2	3	2	4	3	2	2	4	3	0	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:47823721G>A	uc002pgj.1	+	2	736	c.687G>A	c.(685-687)ACG>ACA	p.T229T		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	229	Cytoplasmic (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		TGCTCCGGACGTGGAGCCGCA	0.617													37	83					0	0	0	0	A	47823721	A	A	47823721	2	1	304	1	0	0	0	0	0	0	0	1	2291	1132	40	1		1	C5AR1	19	47823721	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	980886	47823721	11305262	131	56418											
CCDC114	93233	broad.mit.edu	37	chr19	48806034	48806034	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccgagtgcaccttgtccatgCgctgctgcaacaccttctgc	6	10	9	16	2	1	0	0	0	1	0	2	1	2	0	4	0	6	4	4	0	1	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:48806034C>T	uc002pir.2	-	10	1729	c.1046G>A	c.(1045-1047)CGC>CAC	p.R349H	CCDC114_uc002piq.2_Missense_Mutation_p.R158H|CCDC114_uc002pio.2_Missense_Mutation_p.R386H|CCDC114_uc002pis.1_Missense_Mutation_p.R29H|CCDC114_uc002pit.1_Missense_Mutation_p.R386H	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	349	Potential.									ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		CTTGTCCATGCGCTGCTGCAA	0.632													29	61					0	0	0	0	T	48806034	T	T	48806034	3	4	304	1	0	0	0	0	1	0	0	0	2763	768	27	1	986	1	CCDC114	19	48806034	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	982313	48806034	10322949	132	56419											
NTF4	4909	broad.mit.edu	37	chr19	49564963	49564963	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	1	0	0	0	0	cacccagccactgactgcatCgcacacagccagctcacccc	10	4	6	21	1	1	1	1	1	0	0	2	1	1	1	5	0	4	3	5	0	0	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:49564963C>G	uc002pmf.3	-	2	433	c.292G>C	c.(292-294)GAT>CAT	p.D98H	CGB7_uc010yah.1_Intron	NM_006179	NP_006170	P34130	NTF4_HUMAN	neurotrophin 5 preproprotein	98					adult locomotory behavior|epidermis development|ganglion mother cell fate determination|long-term memory|sensory organ boundary specification	endoplasmic reticulum lumen|extracellular region	growth factor activity				0		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		CTGACTGCATCGCACACAGCC	0.697													6	15					0	0	0	0	G	49564963	G	G	49564963	3	3	304	1	0	0	0	0	1	0	0	0	10751	884	31	3	344	3	NTF4	19	49564963	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	758929	49564963	9564020	133	56420											
SIGLEC11	114132	broad.mit.edu	37	chr19	50461907	50461907	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ttcccccactcacagtgcacGgagaggctgagagagacgtg	10	6	13	12	2	1	3	1	1	0	3	2	6	2	3	2	2	1	2	2	2	0	1	rs139230914		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:50461907G>A	uc010ybh.1	-	7	1447	c.1356C>T	c.(1354-1356)TCC>TCT	p.S452S	SIGLEC11_uc010ybi.1_Silent_p.S452S	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	452	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		CACAGTGCACGGAGAGGCTGA	0.652													21	89					0	0	0	0	A	50461907	A	A	50461907	2	1	304	1	0	0	0	0	0	0	0	1	14372	1103	39	1		1	SIGLEC11	19	50461907	Silent	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	896944	50461907	8667076	134	56421											
NLRP11	204801	broad.mit.edu	37	chr19	56321143	56321143	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cattattcccacgtgtgggcCttgaggagatgaggaaccag	10	9	13	9	1	0	3	0	2	0	1	1	5	1	4	3	3	1	0	3	3	2	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:56321143C>A	uc010ygf.1	-	5	1544	c.833G>T	c.(832-834)AGG>ATG	p.R278M	NLRP11_uc002qlz.2_Missense_Mutation_p.R179M|NLRP11_uc002qmb.2_Missense_Mutation_p.R179M|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	278	NACHT.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		ACGTGTGGGCCTTGAGGAGAT	0.463													13	43					0.000151284	0.000162396	1	0	A	56321143	A	A	56321143	3	1	304	1	0	0	0	0	1	0	0	0	10527	681	24	4	2300	4	NLRP11	19	56321143	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	5859236	56321143	2807840	135	56422											
ZNF749	388567	broad.mit.edu	37	chr19	57955756	57955756	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaaggctttataagtgtagcGaatgtgggaaagcctttagc	13	11	12	5	1	0	0	0	0	0	0	0	2	0	1	1	2	3	2	1	2	7	6			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr19:57955756G>A	uc002qoq.2	+	3	1494	c.1240G>A	c.(1240-1242)GAA>AAA	p.E414K	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	414	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TAAGTGTAGCGAATGTGGGAA	0.428													26	58					0	0	0	0	A	57955756	A	A	57955756	3	1	304	1	0	0	0	0	1	0	0	0	18198	1059	37	1	1250	1	ZNF749	19	57955756	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	1634613	57955756	1173227	136	56423											
C20orf103	24141	broad.mit.edu	37	chr20	9510395	9510395	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtaacactcgcgatttaccaCgtccaccacaaaatgactgc	13	8	6	14	3	0	1	0	1	0	0	2	2	1	1	3	0	3	1	3	0	4	3			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr20:9510395C>T	uc002wni.1	+	6	1000	c.771C>T	c.(769-771)CAC>CAT	p.H257H	C20orf103_uc010zrc.1_Silent_p.H213H	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	257	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			CGATTTACCACGTCCACCACA	0.552													12	41					0	0	0	0	T	9510395	T	T	9510395	2	4	304	1	0	0	0	0	0	0	0	1	2085	535	19	1		1	C20orf103	20	9510395	Silent	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		9510395	53515125	137	56424											
CSRP2BP	57325	broad.mit.edu	37	chr20	18123437	18123437	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgatcgtcgaatccgaggatCaggcatcagtggacttatcg	10	10	12	9	4	2	1	2	1	0	0	6	5	3	3	1	3	0	1	1	3	2	1			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr20:18123437C>G	uc002wqj.2	+	2	755	c.133C>G	c.(133-135)CAG>GAG	p.Q45E	CSRP2BP_uc002wqk.2_5'Flank	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	45					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						ATCCGAGGATCAGGCATCAGT	0.547													11	103					0	0	0	0	G	18123437	G	G	18123437	3	3	304	1	0	0	0	0	1	0	0	0	3985	827	29	2	135	2	CSRP2BP	20	18123437	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	8613042	18123437	44902083	138	56425											
SEC23B	10483	broad.mit.edu	37	chr20	18485751	18485751	+	5'Flank	DEL	A	-	-																															taatacattgcctcattcagAaaaaaaaaaaaaaattagga																								rs74180905		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr20:18485751delA	uc002wqz.1	+						SEC23B_uc002wra.1_5'Flank|SEC23B_uc002wrb.1_5'Flank|SEC23B_uc010zsb.1_5'Flank|SEC23B_uc002wrc.1_5'Flank	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B						ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						CCTCATTCAGAAAAAAAAAAA	0.373													---	---	---								-	18485751	-	-	18485751	6	5	304	0	1	1	0	1	0	0	0	0	14057	261	9	0		0	SEC23B	20	18485751	5'Flank	DEL	A	TCGA-IQ-7630-01A-11D-2078-08	362314	18485751	44539769	139	56426											
C20orf114	92747	broad.mit.edu	37	chr20	31876618	31876618	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	tgccgctgctcagtgccatgCgggaaaagccagccggaggc	8	5	15	13	3	1	0	1	0	0	0	1	2	1	2	4	3	6	2	4	3	2	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr20:31876618C>T	uc002wyw.1	+	3	348	c.187C>T	c.(187-189)CGG>TGG	p.R63W	C20orf114_uc010gej.1_Missense_Mutation_p.R63W	NM_033197	NP_149974	Q8TDL5	LPLC1_HUMAN	LPLUNC1 protein precursor	63						extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4						CAGTGCCATGCGGGAAAAGCC	0.627													10	41					0	0	0	0	T	31876618	T	T	31876618	3	4	304	1	0	0	0	0	1	0	0	0	2092	759	27	1	193	1	C20orf114	20	31876618	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	13390867	31876618	31148902	140	56427											
MATN4	8785	broad.mit.edu	37	chr20	43930045	43930045	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tggggaattgacgcagtggtGctcacatccatgggtccctt	7	11	13	10	1	1	1	1	1	0	0	3	2	3	2	2	4	1	2	2	4	1	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr20:43930045G>A	uc002xnn.2	-	4	869	c.682C>T	c.(682-684)CAC>TAC	p.H228Y	MATN4_uc002xno.2_Intron|MATN4_uc002xnp.2_Intron|MATN4_uc010zwr.1_Missense_Mutation_p.H176Y|MATN4_uc002xnr.1_Missense_Mutation_p.H228Y	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	269	EGF-like 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				ACGCAGTGGTGCTCACATCCA	0.557													22	32					0	0	0	0	A	43930045	A	A	43930045	3	1	304	1	0	0	0	0	1	0	0	0	9389	1319	46	4	1091	4	MATN4	20	43930045	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	12053427	43930045	19095475	141	56428											
PARD6B	84612	broad.mit.edu	37	chr20	49354499	49354499	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ataagatccccaatgttgacGttttggtaggctatgcagac	11	12	10	8	1	0	3	0	1	0	2	1	3	1	3	2	2	1	5	2	2	4	6	rs142377445		TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr20:49354499G>A	uc002xvo.2	+	2	415	c.172G>A	c.(172-174)GTT>ATT	p.V58I		NM_032521	NP_115910	Q9BYG5	PAR6B_HUMAN	PAR-6 beta	58	OPR.				axonogenesis|cell cycle|cell division|establishment or maintenance of cell polarity|protein complex assembly|regulation of cell migration|tight junction assembly	cytosol|tight junction	protein binding			kidney(1)	1						CAATGTTGACGTTTTGGTAGG	0.383													35	37					0	0	0	0	A	49354499	A	A	49354499	3	1	304	1	0	0	0	0	1	0	0	0	11500	1145	40	1	178	1	PARD6B	20	49354499	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	5424454	49354499	13671021	142	56429											
GNAS	2778	broad.mit.edu	37	chr20	57415178	57415178	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gaggatggatcggaggtcccGggctcagcagtggcgccgag	7	5	19	10	4	1	0	1	0	0	0	3	5	2	3	2	6	1	2	2	6	0	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr20:57415178G>A	uc002xzt.2	+	1	384	c.17G>A	c.(16-18)CGG>CAG	p.R6Q	GNASAS_uc002xzs.1_Intron|GNAS_uc002xzu.3_5'Flank|GNAS_uc010gjq.2_5'Flank	NM_016592	NP_057676	P63092	GNAS2_HUMAN	GNAS complex locus NESP55	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CGGAGGTCCCGGGCTCAGCAG	0.667			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			30	30					0	0	0	0	A	57415178	A	A	57415178	3	1	304	1	0	0	0	0	1	0	0	0	6547	1116	39	1	19	1	GNAS	20	57415178	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	8060679	57415178	5610342	143	56430											
GNAS	2778	broad.mit.edu	37	chr20	57430002	57430002	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtccgagagcagccgcggccGccgcgtgtactacgatgaag	8	5	15	13	7	0	2	0	1	0	1	1	4	1	2	4	1	4	2	4	1	3	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr20:57430002G>A	uc002xzw.2	+	1	1967	c.1682G>A	c.(1681-1683)CGC>CAC	p.R561H	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			AGCCGCGGCCGCCGCGTGTAC	0.687			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			5	4					0	0	0	0	A	57430002	A	A	57430002	3	1	304	1	0	0	0	0	1	0	0	0	6547	1087	38	1	2426	1	GNAS	20	57430002	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	14824	57430002	5595518	144	56431											
BIRC7	79444	broad.mit.edu	37	chr20	61870794	61870794	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	tgtggaggcgcagctgcggcGgctgcaggaggagaggacgt	7	5	21	8	4	0	1	0	0	0	1	0	5	0	4	0	7	3	4	0	7	0	0			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr20:61870794G>T	uc002yej.2	+	6	907	c.734G>T	c.(733-735)CGG>CTG	p.R245L	BIRC7_uc010gkc.1_3'UTR|BIRC7_uc002yei.2_Missense_Mutation_p.R227L	NM_139317	NP_647478	Q96CA5	BIRC7_HUMAN	livin inhibitor of apoptosis isoform alpha	245					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3	all_cancers(38;2.72e-09)					CAGCTGCGGCGGCTGCAGGAG	0.692													27	31					4.39465e-27	5.09136e-27	1	0	T	61870794	T	T	61870794	3	4	304	1	0	0	0	0	1	0	0	0	1442	1116	39	3	756	3	BIRC7	20	61870794	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08	4440792	61870794	1154726	145	56432											
DSCAM	1826	broad.mit.edu	37	chr21	41561106	41561106	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	1	0	1	0	0	0	atgcgccgtgcagctcatctCctttttctgcccctgcgtgg	3	13	10	15	3	3	0	1	0	2	0	4	0	3	0	4	1	5	2	4	1	0	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr21:41561106C>T	uc002yyq.1	-	12	2868	c.2416G>A	c.(2416-2418)GAG>AAG	p.E806K	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	806	Ig-like C2-type 9.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CAGCTCATCTCCTTTTTCTGC	0.507													23	45					0	0	0	0	T	41561106	T	T	41561106	3	4	304	1	0	0	0	0	1	0	0	0	4790	864	30	2	3710	2	DSCAM	21	41561106	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		41561106	6568789	146	56433											
NF2	4771	broad.mit.edu	37	chr22	30061031	30061031	+	Nonsense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tgtcttcaagtttaactcctCaaagcttcgtgttaataagc	11	15	6	9	1	3	0	2	0	1	0	5	0	4	0	1	0	3	3	1	0	5	6			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr22:30061031C>G	uc003age.3	+	9	1306	c.863C>G	c.(862-864)TCA>TGA	p.S288*	NF2_uc003afy.3_Nonsense_Mutation_p.S288*|NF2_uc003afz.3_Nonsense_Mutation_p.S205*|NF2_uc003agf.3_Nonsense_Mutation_p.S288*|NF2_uc003agb.3_Nonsense_Mutation_p.S211*|NF2_uc003agc.3_Nonsense_Mutation_p.S250*|NF2_uc003agd.3_RNA|NF2_uc003agg.3_Nonsense_Mutation_p.S288*|NF2_uc003aga.3_Nonsense_Mutation_p.S246*|NF2_uc003agh.3_Nonsense_Mutation_p.S247*|NF2_uc003agi.3_Nonsense_Mutation_p.S205*|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Nonsense_Mutation_p.S250*|NF2_uc010gvp.2_5'UTR	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	288	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.L127_D382del(1)|p.F271_L295del(1)|p.?(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						TTTAACTCCTCAAAGCTTCGT	0.353			D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				2	9					0	0	0	0	G	30061031	G	G	30061031	4	3	304	1	0	0	0	0	0	1	0	0	10411	838	29	2	897	2	NF2	22	30061031	Nonsense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08		30061031	21243535	147	56434											
MYH9	4627	broad.mit.edu	37	chr22	36708123	36708123	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	atagtggataatgcagaaatCagctttgtccttcagctgct	11	13	9	8	0	2	1	2	0	0	1	3	2	3	2	1	1	4	4	1	1	3	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chr22:36708123C>T	uc003apg.2	-	14	1930	c.1699G>A	c.(1699-1701)GAT>AAT	p.D567N	MYH9_uc003aph.1_Missense_Mutation_p.D431N	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	567	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						ATGCAGAAATCAGCTTTGTCC	0.582			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				27	28					0	0	0	0	T	36708123	T	T	36708123	3	4	304	1	0	0	0	0	1	0	0	0	10095	826	29	2	4295	2	MYH9	22	36708123	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	6647092	36708123	14596443	148	56435											
DMD	1756	broad.mit.edu	37	chrX	32328384	32328384	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	caccatcatcgtttcttcacGgacagtgtgctggtatagat	9	13	9	10	2	3	1	2	0	1	1	4	2	3	2	1	2	1	3	1	2	2	4			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chrX:32328384G>A	uc004dda.1	-	42	6176	c.5932C>T	c.(5932-5934)CGT>TGT	p.R1978C	DMD_uc004dcw.2_Missense_Mutation_p.R634C|DMD_uc004dcx.2_Missense_Mutation_p.R637C|DMD_uc004dcz.2_Missense_Mutation_p.R1855C|DMD_uc004dcy.1_Missense_Mutation_p.R1974C|DMD_uc004ddb.1_Missense_Mutation_p.R1970C|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1978	Spectrin 13.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GTTTCTTCACGGACAGTGTGC	0.378													8	5					0	0	0	0	A	32328384	A	A	32328384	3	1	304	1	0	0	0	0	1	0	0	0	4602	1116	39	1	5425	1	DMD	23	32328384	Missense_Mutation	SNP	G	TCGA-IQ-7630-01A-11D-2078-08		32328384	122942176	149	56436											
PHKA1	5255	broad.mit.edu	37	chrX	71800893	71800893	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtggggcaggaactcctgcaCgtaggtggcggctgccttgg	5	8	18	10	2	0	0	0	0	0	0	1	1	1	1	2	7	3	4	2	7	2	2			TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chrX:71800893C>T	uc004eax.3	-	32	3932	c.3631G>A	c.(3631-3633)GTG>ATG	p.V1211M	PHKA1_uc004eay.3_Missense_Mutation_p.V1198M|PHKA1_uc011mqi.1_Missense_Mutation_p.V1139M|PHKA1_uc010nll.2_Missense_Mutation_p.V243M	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	1211					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					AACTCCTGCACGTAGGTGGCG	0.567													7	8					0	0	0	0	T	71800893	T	T	71800893	3	4	304	1	0	0	0	0	1	0	0	0	11898	536	19	1	44	1	PHKA1	23	71800893	Missense_Mutation	SNP	C	TCGA-IQ-7630-01A-11D-2078-08	39472509	71800893	83469667	150	56437											
CT47B1	643311	broad.mit.edu	37	chrX	120008979	120008979	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aggccgaggccctcgccttcTggggctgcagcccctgcacc	4	6	13	18	2	1	0	0	0	1	0	2	1	1	0	6	4	3	3	6	4	0	1	rs871733	by1000genomes	TCGA-IQ-7630-01A-11D-2078-08	TCGA-IQ-7630-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	80442509-c2f0-4047-956e-a3633dfd472b	fff52fee-b4e5-4e06-976f-894ca57c3a9e	g.chrX:120008979T>C	uc011muc.1	-	1	801	c.546A>G	c.(544-546)CCA>CCG	p.P182P		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	182											0						CCTCGCCTTCTGGGGCTGCAG	0.711													3	26					0	0	0	0	C	120008979	C	C	120008979	2	2	304	1	0	0	0	0	0	0	0	1	4006	1567	55	5		5	CT47B1	23	120008979	Silent	SNP	T	TCGA-IQ-7630-01A-11D-2078-08	48208086	120008979	35261581	151	56438											
CAMTA1	23261	broad.mit.edu	37	chr1	7812556	7812556	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aaaagcaggatcaagctgctCgaaaaataatgaggtttctt	16	10	9	6	1	2	1	1	1	1	0	3	3	2	2	0	2	3	4	0	2	6	3			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr1:7812556C>T	uc001aoi.2	+	21	5128	c.4921C>T	c.(4921-4923)CGA>TGA	p.R1641*	CAMTA1_uc001aok.3_Nonsense_Mutation_p.R684*|CAMTA1_uc001aoj.2_Nonsense_Mutation_p.R604*|CAMTA1_uc009vmf.2_Nonsense_Mutation_p.R231*	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1641					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCAAGCTGCTCGAAAAATAAT	0.423													11	11					0	0	0	0	T	7812556	T	T	7812556	4	4	305	1	0	0	0	0	0	1	0	0	2625	876	31	1	5003	1	CAMTA1	1	7812556	Nonsense_Mutation	SNP	C	TCGA-IQ-7631-01A-11D-2078-08		7812556	241438065	1	56439											
KIAA1522	57648	broad.mit.edu	37	chr1	33236052	33236052	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cactctcaatcctccgacacCattgtgtctgacggttccac	8	11	6	16	2	2	1	1	1	2	0	6	2	5	1	4	1	0	1	4	1	1	2			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr1:33236052C>T	uc001bvv.2	+	6	1231	c.1095C>T	c.(1093-1095)ACC>ACT	p.T365T	KIAA1522_uc001bvu.1_Silent_p.T424T|KIAA1522_uc010ohm.1_Silent_p.T376T|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	365	Ser-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCTCCGACACCATTGTGTCTG	0.652													12	17					0	0	0	0	T	33236052	T	T	33236052	2	4	305	1	0	0	0	0	0	0	0	1	8277	581	21	4		4	KIAA1522	1	33236052	Silent	SNP	C	TCGA-IQ-7631-01A-11D-2078-08	25423496	33236052	216014569	2	56440											
KIAA0754	643314	broad.mit.edu	37	chr1	39879079	39879079	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccccagctgctgcagtgcccAccccagaggagcccacctcc	7	4	9	21	0	0	1	0	0	0	1	1	2	1	2	8	1	5	3	8	1	0	0			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr1:39879079A>C	uc009vvt.1	+	1	3904	c.3142A>C	c.(3142-3144)ACC>CCC	p.T1048P	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	912	Ala-rich.|3.										0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGCAGTGCCCACCCCAGAGGA	0.726													2	5					0	0	0	0	C	39879079	C	C	39879079	3	2	305	1	0	0	0	0	1	0	0	0	8231	159	6	5	3144	5	KIAA0754	1	39879079	Missense_Mutation	SNP	A	TCGA-IQ-7631-01A-11D-2078-08	6643027	39879079	209371542	3	56441											
DYRK3	8444	broad.mit.edu	37	chr1	206822243	206822243	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	aatagccaataagcttaaagCtaacttaatgtcagaaacca	19	9	5	8	0	1	1	1	0	0	1	1	1	1	1	2	0	5	2	2	0	9	5			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr1:206822243C>G	uc001hej.2	+	3	1868	c.1700C>G	c.(1699-1701)GCT>GGT	p.A567G	DYRK3_uc001hek.2_Intron|DYRK3_uc001hei.2_Missense_Mutation_p.A547G	NM_003582	NP_003573	O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	567					erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|central_nervous_system(1)	3	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			AAGCTTAAAGCTAACTTAATG	0.438													24	41					0	0	0	0	G	206822243	G	G	206822243	3	3	305	1	0	0	0	0	1	0	0	0	4879	797	28	4	1731	4	DYRK3	1	206822243	Missense_Mutation	SNP	C	TCGA-IQ-7631-01A-11D-2078-08	166943164	206822243	42428378	4	56442											
SPATA17	128153	broad.mit.edu	37	chr1	217955575	217955575	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tacaggcctttggagccaacGttgcgggtggcagaaccaat	10	8	13	10	2	0	1	0	0	0	1	0	2	0	2	3	4	5	2	3	4	4	3	rs139943258	by1000genomes	TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr1:217955575G>A	uc001hlh.1	+	8	809	c.783G>A	c.(781-783)ACG>ACA	p.T261T	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Silent_p.T261T	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	261						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TGGAGCCAACGTTGCGGGTGG	0.448													20	39					0	0	0	0	A	217955575	A	A	217955575	2	1	305	1	0	0	0	0	0	0	0	1	15068	1132	40	1		1	SPATA17	1	217955575	Silent	SNP	G	TCGA-IQ-7631-01A-11D-2078-08	11133332	217955575	31295046	5	56443											
SNAP47	116841	broad.mit.edu	37	chr1	227968341	227968341	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agggcaaccttgaccatcgaCaagcacaacaggcggatgaa	15	4	11	11	2	0	2	0	2	0	0	1	4	0	3	2	3	3	2	2	3	4	1			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr1:227968341C>T	uc001hrf.2	+	5	1776	c.1362C>T	c.(1360-1362)GAC>GAT	p.D454D	SNAP47_uc001hra.2_Silent_p.D212D	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	454	t-SNARE coiled-coil homology 2.					endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						TGACCATCGACAAGCACAACA	0.622													13	19					0	0	0	0	T	227968341	T	T	227968341	2	4	305	1	0	0	0	0	0	0	0	1	14896	477	17	4		4	SNAP47	1	227968341	Silent	SNP	C	TCGA-IQ-7631-01A-11D-2078-08	10012766	227968341	21282280	6	56444											
ATAD2B	54454	broad.mit.edu	37	chr2	24111244	24111244	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	gccactatgtccatttggtaAtgtagcaccaggctgagaag	11	10	11	9	0	0	1	0	1	0	1	1	2	1	1	3	2	1	4	3	2	4	4			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr2:24111244A>G	uc002rek.3	-	3	688	c.394T>C	c.(394-396)TTA>CTA	p.L132L	ATAD2B_uc010yki.1_RNA|ATAD2B_uc010exx.1_Silent_p.L132L	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	132							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCATTTGGTAATGTAGCACCA	0.313													2	13					0	0	0	0	G	24111244	G	G	24111244	2	3	305	1	0	0	0	0	0	0	0	1	1074	98	4	5		5	ATAD2B	2	24111244	Silent	SNP	A	TCGA-IQ-7631-01A-11D-2078-08		24111244	219088129	7	56445											
SOS1	6654	broad.mit.edu	37	chr2	39283893	39283893	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttgttttgtaatttcataatGccgtatatttcttacataat	11	21	4	5	1	2	0	1	0	1	0	2	0	2	0	1	0	2	3	1	0	6	11			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr2:39283893G>A	uc002rrk.3	-	4	501	c.460C>T	c.(460-462)CAT>TAT	p.H154Y	SOS1_uc010ynr.1_RNA	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	154					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				ATTTCATAATGCCGTATATTT	0.313									Noonan_syndrome				68	133					0	0	0	0	A	39283893	A	A	39283893	3	1	305	1	0	0	0	0	1	0	0	0	15000	1319	46	4	3621	4	SOS1	2	39283893	Missense_Mutation	SNP	G	TCGA-IQ-7631-01A-11D-2078-08	15172649	39283893	203915480	8	56446											
DQX1	165545	broad.mit.edu	37	chr2	74746713	74746713	+	Silent	SNP	C	T	T	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	0	1	1	0	1	tatcctgacaccagtgctttCtgaaggtctctgcgattctg	7	14	9	11	1	3	2	0	2	3	0	5	3	4	2	2	1	2	1	2	1	2	3			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr2:74746713C>T	uc010yrw.1	-	10	1941	c.1776G>A	c.(1774-1776)CAG>CAA	p.Q592Q	DQX1_uc002smc.2_Silent_p.Q153Q	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	592						nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						CCAGTGCTTTCTGAAGGTCTC	0.483													42	68					0	0	0	0	T	74746713	T	T	74746713	2	4	305	1	0	0	0	0	0	0	0	1	4773	912	32	2		2	DQX1	2	74746713	Silent	SNP	C	TCGA-IQ-7631-01A-11D-2078-08	35462820	74746713	168452660	9	56447											
OBSL1	23363	broad.mit.edu	37	chr2	220432968	220432968	+	Missense_Mutation	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	tggggatgcgggagttgggtActttacattccagcacggca	8	10	15	8	2	0	0	0	0	0	0	1	2	1	2	1	5	4	4	1	5	2	5			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr2:220432968A>C	uc010fwk.2	-	2	1148	c.1091T>G	c.(1090-1092)GTA>GGA	p.V364G	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Missense_Mutation_p.V364G|OBSL1_uc002vmj.2_5'UTR	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	364	Ig-like 4.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GGAGTTGGGTACTTTACATTC	0.662											OREG0003988	type=REGULATORY REGION|Gene=OBSL1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	9	15					0	0	0	0	C	220432968	C	C	220432968	3	2	305	1	0	0	0	0	1	0	0	0	10867	391	14	5	4831	5	OBSL1	2	220432968	Missense_Mutation	SNP	A	TCGA-IQ-7631-01A-11D-2078-08	145686255	220432968	22766405	10	56448											
ZCCHC4	29063	broad.mit.edu	37	chr4	25363860	25363860	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tactctagattttgctctccGtgtcaacggtatgtttctct	6	18	7	10	2	4	1	1	0	3	1	6	1	4	1	1	1	3	3	1	1	4	6			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr4:25363860G>A	uc003grl.3	+	10	1182	c.1146G>A	c.(1144-1146)CCG>CCA	p.P382P	ZCCHC4_uc003grn.3_Silent_p.P148P	NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	382							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				TTTGCTCTCCGTGTCAACGGT	0.338													10	23					0	0	0	0	A	25363860	A	A	25363860	2	1	305	1	0	0	0	0	0	0	0	1	17657	1132	40	1		1	ZCCHC4	4	25363860	Silent	SNP	G	TCGA-IQ-7631-01A-11D-2078-08		25363860	165790416	11	56449											
GFPT2	9945	broad.mit.edu	37	chr5	179765551	179765551	+	Silent	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cccttgatgagggtttcgaaGatctccttcctcgtccgggg	5	12	12	12	3	1	3	0	2	1	1	6	4	3	3	4	3	0	1	4	3	1	3			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr5:179765551G>T	uc003mlw.1	-	2	155	c.57C>A	c.(55-57)ATC>ATA	p.I19I		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	19	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	GGGTTTCGAAGATCTCCTTCC	0.557													16	18					8.60227e-14	9.51741e-14	1	0	T	179765551	T	T	179765551	2	4	305	1	0	0	0	0	0	0	0	1	6383	932	33	2		2	GFPT2	5	179765551	Silent	SNP	G	TCGA-IQ-7631-01A-11D-2078-08		179765551	1149709	12	56450											
SKIV2L	6499	broad.mit.edu	37	chr6	31930806	31930806	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttatcatgctacctgaccaCgtttctatcatccttctgag	8	15	5	13	1	4	2	2	2	2	0	5	2	5	2	3	0	2	2	3	0	3	5			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr6:31930806C>T	uc003nyn.1	+	13	1730	c.1341C>T	c.(1339-1341)CAC>CAT	p.H447H	SKIV2L_uc011dou.1_Silent_p.H289H|SKIV2L_uc011dov.1_Silent_p.H254H	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	447	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TACCTGACCACGTTTCTATCA	0.617													17	30					0	0	0	0	T	31930806	T	T	31930806	2	4	305	1	0	0	0	0	0	0	0	1	14424	535	19	1		1	SKIV2L	6	31930806	Silent	SNP	C	TCGA-IQ-7631-01A-11D-2078-08		31930806	139184261	13	56451											
ZNF735	730291	broad.mit.edu	37	chr7	63680365	63680365	+	Silent	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	tttagcgtatcctcagccctCatttaccacaagagaattca	12	12	5	12	1	3	1	3	0	0	1	4	2	4	1	3	0	3	1	3	0	5	6			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr7:63680365C>G	uc011kdn.1	+	4	936	c.936C>G	c.(934-936)CTC>CTG	p.L312L		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	312	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCTCAGCCCTCATTTACCACA	0.433													35	13					0	0	0	0	G	63680365	G	G	63680365	2	3	305	1	0	0	0	0	0	0	0	1	18191	813	29	2		2	ZNF735	7	63680365	Silent	SNP	C	TCGA-IQ-7631-01A-11D-2078-08		63680365	95458298	14	56452											
TRRAP	8295	broad.mit.edu	37	chr7	98547146	98547146	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gggtgcccagacggctgtgcGccccggttcgcccagcacca	5	5	14	17	4	0	1	0	0	0	1	1	1	0	1	5	3	3	3	5	3	0	1	rs3735363		TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr7:98547146G>A	uc003upp.2	+	35	5083	c.4874G>A	c.(4873-4875)CGC>CAC	p.R1625H	TRRAP_uc011kis.1_Missense_Mutation_p.R1607H|TRRAP_uc003upr.2_Missense_Mutation_p.R1324H	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1625					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity	p.R1607H(1)		ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ACGGCTGTGCGCCCCGGTTCG	0.637													21	34					0	0	0	0	A	98547146	A	A	98547146	3	1	305	1	0	0	0	0	1	0	0	0	16668	1087	38	1	4950	1	TRRAP	7	98547146	Missense_Mutation	SNP	G	TCGA-IQ-7631-01A-11D-2078-08	34866781	98547146	60591517	15	56453											
SERPINE1	5054	broad.mit.edu	37	chr7	100779013	100779013	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cagaccaagagcctctccacGtcgcgcaggcgctgcagaaa	11	4	11	15	4	1	3	0	0	1	3	3	3	1	3	3	1	2	3	3	1	2	0			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr7:100779013G>A	uc003uxt.2	+	7	1166	c.1018G>A	c.(1018-1020)GTC>ATC	p.V340I	SERPINE1_uc011kkj.1_Missense_Mutation_p.V325I|SERPINE1_uc003uxu.1_3'UTR	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	340					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	GCCTCTCCACGTCGCGCAGGC	0.582													16	58					0	0	0	0	A	100779013	A	A	100779013	3	1	305	1	0	0	0	0	1	0	0	0	14176	1145	40	1	1040	1	SERPINE1	7	100779013	Missense_Mutation	SNP	G	TCGA-IQ-7631-01A-11D-2078-08	2231867	100779013	58359650	16	56454											
CNTNAP2	26047	broad.mit.edu	37	chr7	146741040	146741040	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tctgacggtgtggtccggcaCgaattacagcatccgattat	9	11	11	10	4	1	1	0	1	1	0	3	3	3	1	2	3	2	2	2	3	3	2			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr7:146741040C>T	uc003weu.1	+	4	960	c.444C>T	c.(442-444)CAC>CAT	p.H148H		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	148	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGGTCCGGCACGAATTACAGC	0.423										HNSCC(39;0.1)			29	88					0	0	0	0	T	146741040	T	T	146741040	2	4	305	1	0	0	0	0	0	0	0	1	3662	535	19	1		1	CNTNAP2	7	146741040	Silent	SNP	C	TCGA-IQ-7631-01A-11D-2078-08	45962027	146741040	12397623	17	56455											
ZNF862	643641	broad.mit.edu	37	chr7	149545305	149545305	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	ttcactgcagattgccccatAttctaccccccagggcctct	7	11	6	17	0	3	1	1	0	2	1	3	1	3	1	6	1	3	1	6	1	2	5			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr7:149545305A>C	uc010lpn.2	+	4	915	c.723A>C	c.(721-723)ATA>ATC	p.I241I	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	241					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1						ATTGCCCCATATTCTACCCCC	0.607													8	14					0	0	0	0	C	149545305	C	C	149545305	2	2	305	1	0	0	0	0	0	0	0	1	18262	439	16	5		5	ZNF862	7	149545305	Silent	SNP	A	TCGA-IQ-7631-01A-11D-2078-08	2804265	149545305	9593358	18	56456											
DLC1	10395	broad.mit.edu	37	chr8	12950234	12950234	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tttacggctgctgtgacatcGctcaggaaataaagcagggt	11	10	12	8	2	1	1	1	1	0	0	2	2	1	2	0	3	3	4	0	3	4	3	rs142586910		TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr8:12950234G>A	uc003wwm.2	-	13	4071	c.3627C>T	c.(3625-3627)AGC>AGT	p.S1209S	DLC1_uc003wwk.1_Silent_p.S772S|DLC1_uc003wwl.1_Silent_p.S806S|DLC1_uc011kxx.1_Silent_p.S698S	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1209	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CTGTGACATCGCTCAGGAAAT	0.562													10	18					0	0	0	0	A	12950234	A	A	12950234	2	1	305	1	0	0	0	0	0	0	0	1	4572	1078	38	1		1	DLC1	8	12950234	Silent	SNP	G	TCGA-IQ-7631-01A-11D-2078-08		12950234	133413788	19	56457											
C8orf73	642475	broad.mit.edu	37	chr8	144652142	144652142	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgaagaaggccatagcCgtgagacgctgcgggtcgtc	8	7	15	11	4	0	3	0	2	0	2	2	4	0	3	3	2	2	1	3	2	3	1			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr8:144652142C>T	uc010mff.2	-	7	1181	c.1137G>A	c.(1135-1137)ACG>ACA	p.T379T	C8orf73_uc010mfg.1_Missense_Mutation_p.G392S	NM_001100878	NP_001094348	A6NGR9	CH073_HUMAN	hypothetical protein LOC642475	379	Leu-rich.						binding			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AGGCCATAGCCGTGAGACGCT	0.657													12	26					0	0	0	0	T	144652142	T	T	144652142	2	4	305	1	0	0	0	0	0	0	0	1	2447	639	23	1		1	C8orf73	8	144652142	Silent	SNP	C	TCGA-IQ-7631-01A-11D-2078-08	131701908	144652142	1711880	20	56458											
SPIN1	10927	broad.mit.edu	37	chr9	91041469	91041469	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	agatgaatgaagaccccattCggaaagacacctggccagcg	14	5	11	11	2	0	5	0	2	0	3	1	6	0	6	4	2	1	0	4	2	3	1			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr9:91041469C>T	uc010mqj.2	+	2	515	c.15C>T	c.(13-15)TTC>TTT	p.F5F	SPIN1_uc004apy.2_Silent_p.F5F|SPIN1_uc004apz.2_Silent_p.F5F|SPIN1_uc010mqk.2_Silent_p.F5F	NM_006717	NP_006708	Q9Y657	SPIN1_HUMAN	spindlin	5					cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding				0						AGACCCCATTCGGAAAGACAC	0.383													11	23					0	0	0	0	T	91041469	T	T	91041469	2	4	305	1	0	0	0	0	0	0	0	1	15118	883	31	1		1	SPIN1	9	91041469	Silent	SNP	C	TCGA-IQ-7631-01A-11D-2078-08		91041469	50171962	21	56459											
PLAU	5328	broad.mit.edu	37	chr10	75673068	75673068	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gaacccagacaaccggaggcGaccctggtgctatgtgcagg	10	5	14	12	2	0	1	0	0	0	1	0	4	0	2	3	4	4	2	3	4	3	1			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr10:75673068G>A	uc001jwa.2	+	6	535	c.389G>A	c.(388-390)CGA>CAA	p.R130Q	C10orf55_uc001jvz.1_Intron|PLAU_uc010qkw.1_Missense_Mutation_p.R113Q|PLAU_uc010qkx.1_Missense_Mutation_p.R44Q|PLAU_uc001jwb.2_RNA|PLAU_uc001jwc.2_Missense_Mutation_p.R130Q|PLAU_uc009xrq.1_Missense_Mutation_p.R94Q	NM_002658	NP_002649	P00749	UROK_HUMAN	plasminogen activator, urokinase isoform 1	130	Kringle.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(2)|kidney(1)	3	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	AACCGGAGGCGACCCTGGTGC	0.572													44	61					0	0	0	0	A	75673068	A	A	75673068	3	1	305	1	0	0	0	0	1	0	0	0	12077	1058	37	1	445	1	PLAU	10	75673068	Missense_Mutation	SNP	G	TCGA-IQ-7631-01A-11D-2078-08		75673068	59861679	22	56460											
WAPAL	23063	broad.mit.edu	37	chr10	88259577	88259580	+	Frame_Shift_Del	DEL	TCTT	-	-																															tttagttctttttttgcttgTctttctttctacttgacagt																										TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr10:88259577_88259580delTCTT	uc001kdo.2	-	3	1862_1865	c.1420_1423delAAGA	c.(1420-1425)AAGACAfs	p.K474fs	WAPAL_uc001kdn.2_Frame_Shift_Del_p.K517fs|WAPAL_uc009xsw.2_Frame_Shift_Del_p.K474fs	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	474_475	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						TTTTTGCTTGTCTTTCTTTCTACT	0.402													---	---	---								-	88259580	-	-	88259577	7	5	305	1	0	1	0	1	0	0	0	0	17316	1667	58	0	2217	0	WAPAL	10	88259577	Frame_Shift_Del	DEL	TCTT	TCGA-IQ-7631-01A-11D-2078-08	12586509	88259577	47275170	23	56461											
GRK5	2869	broad.mit.edu	37	chr10	121156223	121156223	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ttaggcagaatatgaagttaCtccagatgaaaaactgggag	16	9	11	5	0	0	4	0	2	0	2	1	5	1	5	1	2	2	2	1	2	7	3			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr10:121156223C>T	uc001led.2	+	4	511	c.278C>T	c.(277-279)ACT>ATT	p.T93I	GRK5_uc009xzh.2_5'UTR|GRK5_uc010qta.1_5'UTR	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	93	N-terminal.|RGS.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		TATGAAGTTACTCCAGATGAA	0.358													31	36					0	0	0	0	T	121156223	T	T	121156223	3	4	305	1	0	0	0	0	1	0	0	0	6831	565	20	4	292	4	GRK5	10	121156223	Missense_Mutation	SNP	C	TCGA-IQ-7631-01A-11D-2078-08	32896646	121156223	14378524	24	56462											
KNTC1	9735	broad.mit.edu	37	chr12	123073283	123073283	+	Frame_Shift_Del	DEL	A	-	-																															ttggagagactacattagttAaatcaaggcatgttgttatg																										TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr12:123073283delA	uc001ucv.2	+	40	4082	c.3919delA	c.(3919-3921)AAAfs	p.K1307fs	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1307					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TACATTAGTTAAATCAAGGCA	0.274													---	---	---								-	123073283	-	-	123073283	7	5	305	1	0	1	0	1	0	0	0	0	8467	363	13	0	4073	0	KNTC1	12	123073283	Frame_Shift_Del	DEL	A	TCGA-IQ-7631-01A-11D-2078-08		123073283	10778612	25	56463											
ADAM10	102	broad.mit.edu	37	chr15	58974499	58974499	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gggaagtgtccctcttcattCgtaggttgaaatgtctgtaa	9	14	11	7	1	3	1	1	1	2	0	5	2	4	2	1	2	0	3	1	2	4	5			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr15:58974499C>T	uc002afd.1	-	3	665	c.221G>A	c.(220-222)CGA>CAA	p.R74Q	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Intron|ADAM10_uc002afe.1_Intron|ADAM10_uc002afg.2_Missense_Mutation_p.R74Q	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	74	Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		CCTCTTCATTCGTAGGTTGAA	0.294													12	31					0	0	0	0	T	58974499	T	T	58974499	3	4	305	1	0	0	0	0	1	0	0	0	234	884	31	1	2081	1	ADAM10	15	58974499	Missense_Mutation	SNP	C	TCGA-IQ-7631-01A-11D-2078-08		58974499	43556893	26	56464											
TPSAB1	7177	broad.mit.edu	37	chr16	1292129	1292129	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gaatggcacctggctgcaggCgggcgtggtcagctggggcg	5	6	20	10	3	1	0	1	0	0	0	1	1	1	0	1	7	2	4	1	7	1	0			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr16:1292129C>T	uc002ckz.2	+	6	768	c.716C>T	c.(715-717)GCG>GTG	p.A239V	TPSAB1_uc010uux.1_Missense_Mutation_p.A175V	NM_003294	NP_003285	Q15661	TRYB1_HUMAN	tryptase alpha/beta 1 precursor	239	Peptidase S1.				defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				TGGCTGCAGGCGGGCGTGGTC	0.672													8	26					0	0	0	0	T	1292129	T	T	1292129	3	4	305	1	0	0	0	0	1	0	0	0	16490	768	27	1	734	1	TPSAB1	16	1292129	Missense_Mutation	SNP	C	TCGA-IQ-7631-01A-11D-2078-08		1292129	89062624	27	56465											
CREBBP	1387	broad.mit.edu	37	chr16	3828020	3828020	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	taaaatccttacttggaggtCtcacaggttgtgcctgtgga	9	13	11	8	0	1	0	1	0	1	0	3	2	2	2	2	4	2	1	2	4	3	4			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr16:3828020C>G	uc002cvv.2	-	10	2309	c.2105G>C	c.(2104-2106)AGA>ACA	p.R702T	CREBBP_uc002cvw.2_Missense_Mutation_p.R664T	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	702					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		ACTTGGAGGTCTCACAGGTTG	0.502			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				30	131					0	0	0	0	G	3828020	G	G	3828020	3	3	305	1	0	0	0	0	1	0	0	0	3876	913	32	2	5311	2	CREBBP	16	3828020	Missense_Mutation	SNP	C	TCGA-IQ-7631-01A-11D-2078-08	2535891	3828020	86526733	28	56466											
CCDC135	84229	broad.mit.edu	37	chr16	57734141	57734141	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	gctgtgcccagtttgtctccGacttcctcaccatggtgccc	4	12	9	16	1	2	0	1	0	1	0	4	1	3	0	5	1	2	2	5	1	0	2			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr16:57734141G>A	uc002emi.2	+	4	552	c.463G>A	c.(463-465)GAC>AAC	p.D155N	CCDC135_uc002emj.2_Missense_Mutation_p.D155N|CCDC135_uc002emk.2_Missense_Mutation_p.D155N	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	155						cytoplasm				central_nervous_system(1)	1						GTTTGTCTCCGACTTCCTCAC	0.567													29	89					0	0	0	0	A	57734141	A	A	57734141	3	1	305	1	0	0	0	0	1	0	0	0	2781	1058	37	1	473	1	CCDC135	16	57734141	Missense_Mutation	SNP	G	TCGA-IQ-7631-01A-11D-2078-08	53906121	57734141	32620612	29	56467											
MYH13	8735	broad.mit.edu	37	chr17	10204957	10204957	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agcgatgtccgccctctccgCggcctcctctagctcatgct	4	10	9	18	4	3	0	1	0	2	0	6	1	5	0	5	1	3	2	5	1	1	1			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr17:10204957C>T	uc002gmk.1	-	40	5821	c.5731G>A	c.(5731-5733)GCG>ACG	p.A1911T		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1911	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GCCCTCTCCGCGGCCTCCTCT	0.622													36	61					0	0	0	0	T	10204957	T	T	10204957	3	4	305	1	0	0	0	0	1	0	0	0	10085	768	27	1	93	1	MYH13	17	10204957	Missense_Mutation	SNP	C	TCGA-IQ-7631-01A-11D-2078-08		10204957	70990253	30	56468											
SALL3	27164	broad.mit.edu	37	chr18	76754998	76754998	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	accgcagccatactaaggagCggccattcgtctgcgcgctc	8	7	11	15	5	1	0	0	0	1	0	3	1	1	1	3	2	4	2	3	2	2	3			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr18:76754998C>T	uc002lmt.2	+	2	3007	c.3007C>T	c.(3007-3009)CGG>TGG	p.R1003W	SALL3_uc010dra.2_Intron	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1003					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TACTAAGGAGCGGCCATTCGT	0.537													14	37					0	0	0	0	T	76754998	T	T	76754998	3	4	305	1	0	0	0	0	1	0	0	0	13877	759	27	1	3013	1	SALL3	18	76754998	Missense_Mutation	SNP	C	TCGA-IQ-7631-01A-11D-2078-08		76754998	1322250	31	56469											
FCAR	2204	broad.mit.edu	37	chr19	55396849	55396849	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ttcgtcattgaccacatggaCgcaaacaaggcagggcgcta	12	7	11	11	3	1	1	1	1	0	0	2	2	1	2	1	3	1	3	1	3	3	3			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr19:55396849C>T	uc002qhr.1	+	3	470	c.273C>T	c.(271-273)GAC>GAT	p.D91D	FCAR_uc002qhq.2_Silent_p.D91D|FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Silent_p.D64D|FCAR_uc010esi.1_Silent_p.D64D|FCAR_uc002qhu.1_Silent_p.D91D|FCAR_uc002qhv.1_Silent_p.D91D|FCAR_uc002qhw.1_Silent_p.D79D|FCAR_uc002qhx.1_Silent_p.D79D|FCAR_uc002qhy.1_Silent_p.D79D|FCAR_uc002qhz.1_Silent_p.D79D|FCAR_uc002qia.1_Intron	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	91	Extracellular (Potential).|Ig-like C2-type 1.				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		ACCACATGGACGCAAACAAGG	0.483													14	35					0	0	0	0	T	55396849	T	T	55396849	2	4	305	1	0	0	0	0	0	0	0	1	5805	535	19	1		1	FCAR	19	55396849	Silent	SNP	C	TCGA-IQ-7631-01A-11D-2078-08		55396849	3732134	32	56470											
SUN5	140732	broad.mit.edu	37	chr20	31571672	31571672	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acagagccatgcactcgcacGcggtacaggcaagtgaagcc	12	4	12	13	3	0	2	0	1	0	1	1	2	0	2	2	2	4	4	2	2	3	1			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chr20:31571672G>A	uc002wyi.2	-	13	1161	c.1068C>T	c.(1066-1068)CGC>CGT	p.R356R		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	356	SUN.				spermatogenesis					skin(1)	1						GCACTCGCACGCGGTACAGGC	0.562													40	75					0	0	0	0	A	31571672	A	A	31571672	2	1	305	1	0	0	0	0	0	0	0	1	15460	1074	38	1		1	SUN5	20	31571672	Silent	SNP	G	TCGA-IQ-7631-01A-11D-2078-08		31571672	31453848	33	56471											
FAM47A	158724	broad.mit.edu	37	chrX	34150181	34150181	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggagtaaaaactcgtcacggCgacaaacgagagtatcttcg	14	7	11	9	5	2	1	1	0	1	1	4	4	2	2	0	2	2	2	0	2	5	3			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chrX:34150181C>T	uc004ddg.2	-	1	248	c.215G>A	c.(214-216)CGC>CAC	p.R72H		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	72								p.R72H(1)		ovary(4)|central_nervous_system(1)	5						CTCGTCACGGCGACAAACGAG	0.537													28	58					0	0	0	0	T	34150181	T	T	34150181	3	4	305	1	0	0	0	0	1	0	0	0	5601	768	27	1	2164	1	FAM47A	23	34150181	Missense_Mutation	SNP	C	TCGA-IQ-7631-01A-11D-2078-08		34150181	121120379	34	56472			1	80		2	2	40	C		4.913185e-05
FAM47A	158724	broad.mit.edu	37	chrX	34150220	34150220	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	cgggagacggacagccgtagCggaagtcgtccatgccctcc	8	5	14	14	5	0	1	0	0	0	1	3	4	2	3	4	3	3	1	4	3	2	1			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chrX:34150220C>T	uc004ddg.2	-	1	209	c.176G>A	c.(175-177)CGC>CAC	p.R59H		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	59										ovary(4)|central_nervous_system(1)	5						ACAGCCGTAGCGGAAGTCGTC	0.557													32	47					0	0	0	0	T	34150220	T	T	34150220	3	4	305	1	0	0	0	0	1	0	0	0	5601	768	27	1	2203	1	FAM47A	23	34150220	Missense_Mutation	SNP	C	TCGA-IQ-7631-01A-11D-2078-08	39	34150220	121120340	35	56473			1	80		2	2	40	C		4.913185e-05
USP9X	8239	broad.mit.edu	37	chrX	41088917	41088919	+	In_Frame_Del	DEL	ACA	-	-																															tggcaatcctcagtacacttAcaacaattggtctcccccag																										TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chrX:41088917_41088919delACA	uc004dfb.2	+	43	7949_7951	c.7316_7318delACA	c.(7315-7320)TACAAC>TAC	p.N2441del	USP9X_uc004dfc.2_In_Frame_Del_p.N2441del	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2441					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						CAGTACACTTACAACAATTGGTC	0.438													---	---	---								-	41088919	-	-	41088917	7	5	305	1	0	1	0	1	0	0	0	0	17158	391	14	0	7482	0	USP9X	23	41088917	In_Frame_Del	DEL	ACA	TCGA-IQ-7631-01A-11D-2078-08	6938697	41088917	114181643	36	56474											
MED12	9968	broad.mit.edu	37	chrX	70347218	70347218	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	cgtgaagcatgggatgaaccGgtccgatggctcctctgcag	8	8	14	11	3	1	2	0	2	1	0	3	4	3	3	3	3	3	3	3	3	2	0			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chrX:70347218G>A	uc004dyy.2	+	21	3081	c.2882G>A	c.(2881-2883)CGG>CAG	p.R961Q	MED12_uc011mpq.1_Missense_Mutation_p.R961Q|MED12_uc004dyz.2_Missense_Mutation_p.R961Q|MED12_uc004dza.2_Missense_Mutation_p.R808Q|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	961			R -> W (in OKS).		androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GGGATGAACCGGTCCGATGGC	0.522													10	23					0	0	0	0	A	70347218	A	A	70347218	3	1	305	1	0	0	0	0	1	0	0	0	9481	1116	39	1	2964	1	MED12	23	70347218	Missense_Mutation	SNP	G	TCGA-IQ-7631-01A-11D-2078-08	29258301	70347218	84923342	37	56475											
ODZ1	10178	broad.mit.edu	37	chrX	123538975	123538975	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	cattgtgctctccgggcaatGagatgttgcatttgcccagg	7	12	12	10	1	1	1	0	1	1	1	2	2	1	1	2	2	3	4	2	2	1	3			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chrX:123538975G>A	uc004euj.2	-	26	5340	c.5276C>T	c.(5275-5277)TCA>TTA	p.S1759L	ODZ1_uc011muj.1_Missense_Mutation_p.S1765L|ODZ1_uc010nqy.2_Missense_Mutation_p.S1766L	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1759	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCCGGGCAATGAGATGTTGCA	0.562													44	83					0	0	0	0	A	123538975	A	A	123538975	3	1	305	1	0	0	0	0	1	0	0	0	10888	1294	45	2	2925	2	ODZ1	23	123538975	Missense_Mutation	SNP	G	TCGA-IQ-7631-01A-11D-2078-08	53191757	123538975	31731585	38	56476											
ODZ1	10178	broad.mit.edu	37	chrX	123556319	123556319	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gagtggagtgaattgctaccTtgctgaccaggaaatgatcg	11	10	13	7	1	0	3	0	3	0	0	1	6	0	5	2	2	3	2	2	2	3	3			TCGA-IQ-7631-01A-11D-2078-08	TCGA-IQ-7631-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	b2266f1c-1642-4849-9278-41e827691aa7	20260058-c3b7-4a04-b502-6f8d3c6687f2	g.chrX:123556319T>A	uc004euj.2	-	23	4317	c.4253A>T	c.(4252-4254)AAG>ATG	p.K1418M	ODZ1_uc011muj.1_Missense_Mutation_p.K1424M|ODZ1_uc010nqy.2_Missense_Mutation_p.K1425M	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1418	NHL 4.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AATTGCTACCTTGCTGACCAG	0.532													38	51					0	0	0	0	A	123556319	A	A	123556319	3	1	305	1	0	0	0	0	1	0	0	0	10888	1609	56	5	3960	5	ODZ1	23	123556319	Missense_Mutation	SNP	T	TCGA-IQ-7631-01A-11D-2078-08	17344	123556319	31714241	39	56477											
PRAMEF11	440560	broad.mit.edu	37	chr1	12887574	12887574	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catccttggacagtcctgcaCtggtgttttgttcctcttgg	4	16	10	11	0	1	0	0	0	1	0	4	1	4	1	3	3	1	3	3	3	0	5			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:12887574C>G	uc001auk.2	-	3	479	c.283G>C	c.(283-285)GTG>CTG	p.V95L		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	95											0						CAGTCCTGCACTGGTGTTTTG	0.498													11	236					0	0	0	0	G	12887574	G	G	12887574	3	3	306	1	0	0	0	0	1	0	0	0	12487	565	20	4	1035	4	PRAMEF11	1	12887574	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08		12887574	236363047	1	56478											
TTF2	8458	broad.mit.edu	37	chr1	117624536	117624536	+	Nonsense_Mutation	SNP	A	T	T	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaaaaggaagaaaaggagAaaagcacagctttgacgtgg	20	4	13	4	1	0	4	0	1	0	3	0	6	0	5	0	3	2	2	0	3	7	1			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:117624536A>T	uc001egy.2	+	10	1890	c.1870A>T	c.(1870-1872)AAA>TAA	p.K624*	TTF2_uc001egx.1_Nonsense_Mutation_p.K624*	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	624	Helicase ATP-binding.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		AGAAAAGGAGAAAAGCACAGC	0.453													5	53					0	0	0	0	T	117624536	T	T	117624536	4	4	306	1	0	0	0	0	0	1	0	0	16787	247	9	5	1908	5	TTF2	1	117624536	Nonsense_Mutation	SNP	A	TCGA-IQ-7632-01A-11D-2078-08	104736962	117624536	131626085	2	56479											
FLG	2312	broad.mit.edu	37	chr1	152280551	152280551	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	atctcttgactgctcctgagCagatccatgatggtttctgg	7	14	10	10	0	2	4	0	3	2	1	5	4	4	4	2	2	2	3	2	2	0	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:152280551C>A	uc001ezu.1	-	3	6847	c.6811G>T	c.(6811-6813)GCT>TCT	p.A2271S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2271	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCCTGAGCAGATCCATGA	0.582									Ichthyosis				25	264					5.45024e-15	8.13587e-15	1	0	A	152280551	A	A	152280551	3	1	306	1	0	0	0	0	1	0	0	0	5954	710	25	4	5378	4	FLG	1	152280551	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	34656015	152280551	96970070	3	56480											
C1orf114	57821	broad.mit.edu	37	chr1	169390949	169390949	+	Silent	SNP	A	C	C	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctatttgcattattaatgggAggcaaaaacccctgactggc	12	11	9	9	0	0	1	0	1	0	0	0	2	0	2	2	3	2	2	2	3	5	4			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:169390949A>C	uc001gga.1	-	3	888	c.720T>G	c.(718-720)CCT>CCG	p.P240P	C1orf114_uc001gfz.1_Silent_p.P240P|C1orf114_uc009wvq.1_Silent_p.P240P|C1orf114_uc001ggb.2_Silent_p.P240P|C1orf114_uc001ggc.1_Silent_p.P240P	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	240											0	all_hematologic(923;0.208)					TATTAATGGGAGGCAAAAACC	0.408													17	109					0	0	0	0	C	169390949	C	C	169390949	2	2	306	1	0	0	0	0	0	0	0	1	1996	291	11	5		5	C1orf114	1	169390949	Silent	SNP	A	TCGA-IQ-7632-01A-11D-2078-08	17110398	169390949	79859672	4	56481											
SRGAP2	23380	broad.mit.edu	37	chr1	206628236	206628236	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	tcccccagcgaggacggtgtCgtggagaggtccagccccaa	8	5	14	14	3	0	1	0	0	0	1	3	4	2	2	5	4	2	0	5	4	1	0			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:206628236C>T	uc001hdy.2	+	18	2445	c.2112C>T	c.(2110-2112)GTC>GTT	p.V704V	SRGAP2_uc001hdx.2_Silent_p.V704V|SRGAP2_uc010pru.1_Silent_p.V627V	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	791					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					AGGACGGTGTCGTGGAGAGGT	0.597													4	34					0	0	0	0	T	206628236	T	T	206628236	2	4	306	1	0	0	0	0	0	0	0	1	15212	871	31	1		1	SRGAP2	1	206628236	Silent	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	37237287	206628236	42622385	5	56482											
SLC6A6	6533	broad.mit.edu	37	chr3	14526472	14526472	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcgcaccgtcatgaacggcgCtctcgtgaaaccgacccaca	10	6	9	16	6	2	2	1	2	1	0	4	3	2	2	3	1	2	2	3	1	2	0			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr3:14526472C>T	uc010heg.2	+	22	2111	c.1820C>T	c.(1819-1821)GCT>GTT	p.A607V	SLC6A6_uc003byq.2_Missense_Mutation_p.A607V|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	607	Cytoplasmic (Potential).				cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						ATGAACGGCGCTCTCGTGAAA	0.577													3	22					0	0	0	0	T	14526472	T	T	14526472	3	4	306	1	0	0	0	0	1	0	0	0	14752	797	28	4	1874	4	SLC6A6	3	14526472	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08		14526472	183495958	6	56483											
GRM2	2912	broad.mit.edu	37	chr3	51743211	51743211	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	catgctttttgcactggaccGcatcaaccgtgacccgcacc	8	9	8	16	3	1	1	1	1	0	0	1	2	1	2	4	1	3	4	4	1	1	2	rs144180122	by1000genomes	TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr3:51743211G>A	uc010hlv.2	+	2	451	c.212G>A	c.(211-213)CGC>CAC	p.R71H	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	71	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCACTGGACCGCATCAACCGT	0.632													8	89					0	0	0	0	A	51743211	A	A	51743211	3	1	306	1	0	0	0	0	1	0	0	0	6836	1087	38	1	214	1	GRM2	3	51743211	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	37216739	51743211	146279219	7	56484											
SLC4A4	8671	broad.mit.edu	37	chr4	72412192	72412192	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	1	0	1	1	0	1	gctcacatcgacagtttgaaGatggagacagagacttctgc	12	9	11	9	1	2	4	1	1	1	3	3	7	2	4	0	1	1	2	0	1	1	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr4:72412192G>A	uc003hfy.2	+	19	2685	c.2568G>A	c.(2566-2568)AAG>AAA	p.K856K	SLC4A4_uc010iic.2_Silent_p.K856K|SLC4A4_uc010iib.2_Intron|SLC4A4_uc003hfz.2_Silent_p.K856K|SLC4A4_uc003hgc.3_Silent_p.K812K|SLC4A4_uc010iid.2_Silent_p.K60K	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	856	Extracellular (Potential).			K -> R (in Ref. 4; AAG47773).		basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			ACAGTTTGAAGATGGAGACAG	0.483													6	46					0	0	0	0	A	72412192	A	A	72412192	2	1	306	1	0	0	0	0	0	0	0	1	14720	933	33	2		2	SLC4A4	4	72412192	Silent	SNP	G	TCGA-IQ-7632-01A-11D-2078-08		72412192	118742084	8	56485											
LRBA	987	broad.mit.edu	37	chr4	151509256	151509256	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	atccacctcaaaatagagttCggaggaggtgacagaaagag	16	6	12	7	1	1	4	1	1	0	3	3	6	2	6	2	3	0	1	2	3	4	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr4:151509256C>T	uc010ipj.2	-	41	6781	c.6307G>A	c.(6307-6309)GAA>AAA	p.E2103K	LRBA_uc003ilt.3_Missense_Mutation_p.E751K|LRBA_uc003ilu.3_Missense_Mutation_p.E2092K	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2103						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					AAATAGAGTTCGGAGGAGGTG	0.463													10	91					0	0	0	0	T	151509256	T	T	151509256	3	4	306	1	0	0	0	0	1	0	0	0	8981	893	31	1	2356	1	LRBA	4	151509256	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	79097064	151509256	39645020	9	56486											
SLC38A9	153129	broad.mit.edu	37	chr5	54922346	54922346	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	ataaaaaactgaacaatcagGttagccacgcccaaaatgat	19	7	6	9	1	1	2	1	2	0	0	1	2	1	2	2	1	3	1	2	1	8	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:54922346G>T	uc003jqf.2	-	16	1863	c.1662C>A	c.(1660-1662)AAC>AAA	p.N554K	SLC38A9_uc003jqd.2_Missense_Mutation_p.N491K|SLC38A9_uc010ivx.2_Missense_Mutation_p.N491K|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Missense_Mutation_p.N425K	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	554	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				GAACAATCAGGTTAGCCACGC	0.368													12	86					0.000978159	0.00129167	1	0	T	54922346	T	T	54922346	3	4	306	1	0	0	0	0	1	0	0	0	14675	1252	44	4	27	4	SLC38A9	5	54922346	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08		54922346	125992914	10	56487											
DDX4	54514	broad.mit.edu	37	chr5	55110956	55110956	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttccttttttgatcttgaatCggataaccatttagcacagc	10	16	6	9	1	1	2	0	2	1	0	3	3	2	3	2	1	3	1	2	1	3	8			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:55110956C>T	uc003jqg.3	+	20	2017	c.1943C>T	c.(1942-1944)TCG>TTG	p.S648L	DDX4_uc010ivz.2_Missense_Mutation_p.S628L|DDX4_uc003jqh.3_Missense_Mutation_p.S614L|DDX4_uc003jqj.2_Missense_Mutation_p.S499L	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	648	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				GATCTTGAATCGGATAACCAT	0.358													6	104					0	0	0	0	T	55110956	T	T	55110956	3	4	306	1	0	0	0	0	1	0	0	0	4377	893	31	1	2058	1	DDX4	5	55110956	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	188610	55110956	125804304	11	56488											
HTR1A	3350	broad.mit.edu	37	chr5	63256816	63256816	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	tgggctgcggggcgggagatGctccatggcgggtgtccgct	3	8	20	10	4	0	1	0	0	0	1	2	2	2	1	2	6	2	3	2	6	0	0			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:63256816G>A	uc011cqt.1	-	1	731	c.731C>T	c.(730-732)GCA>GTA	p.A244V		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	244	Cytoplasmic (By similarity).			A -> AA (in Ref. 8).	behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GGCGGGAGATGCTCCATGGCG	0.632													8	56					0	0	0	0	A	63256816	A	A	63256816	3	1	306	1	0	0	0	0	1	0	0	0	7475	1319	46	4	540	4	HTR1A	5	63256816	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	8145860	63256816	117658444	12	56489											
PCSK1	5122	broad.mit.edu	37	chr5	95746485	95746485	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aaaagcaacatacgattctcTggtcggtgtaatctccgctg	11	11	9	10	3	2	0	0	0	2	0	5	1	2	0	1	2	3	3	1	2	5	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:95746485T>A	uc003kls.1	-	8	1294	c.1088A>T	c.(1087-1089)CAG>CTG	p.Q363L	PCSK1_uc010jbi.1_Intron	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	363	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TACGATTCTCTGGTCGGTGTA	0.512													10	80					0	0	0	0	A	95746485	A	A	95746485	3	1	306	1	0	0	0	0	1	0	0	0	11654	1580	55	5	1201	5	PCSK1	5	95746485	Missense_Mutation	SNP	T	TCGA-IQ-7632-01A-11D-2078-08	32489669	95746485	85168775	13	56490											
KDM3B	51780	broad.mit.edu	37	chr5	137727180	137727180	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	taccccagagaatcatgaaaAtctatttttacagcccccca	14	10	4	13	0	2	2	1	1	1	1	2	3	2	2	5	0	3	0	5	0	6	5			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:137727180A>G	uc003lcy.1	+	8	2059	c.1859A>G	c.(1858-1860)AAT>AGT	p.N620S	KDM3B_uc010jew.1_Missense_Mutation_p.N276S|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	620					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AATCATGAAAATCTATTTTTA	0.507													13	104					0	0	0	0	G	137727180	G	G	137727180	3	3	306	1	0	0	0	0	1	0	0	0	8166	101	4	5	1889	5	KDM3B	5	137727180	Missense_Mutation	SNP	A	TCGA-IQ-7632-01A-11D-2078-08	41980695	137727180	43188080	14	56491											
PCDHGB3	56102	broad.mit.edu	37	chr5	140751490	140751490	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	ctacgtgtccgtgagcgcgcGgagcggggtggtgttcgcgc	3	8	19	11	8	0	1	0	1	0	0	2	2	1	2	1	4	3	1	1	4	1	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:140751490G>A	uc003ljw.1	+	1	1529	c.1529G>A	c.(1528-1530)CGG>CAG	p.R510Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.R510Q|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	510	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAGCGCGCGGAGCGGGGTG	0.667													10	50					0	0	0	0	A	140751490	A	A	140751490	3	1	306	1	0	0	0	0	1	0	0	0	11618	1116	39	1	1531	1	PCDHGB3	5	140751490	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	3024310	140751490	40163770	15	56492											
FAM193B	54540	broad.mit.edu	37	chr5	176951739	176951739	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttgagtctcctcacgagcccGttctcggggacgataccggg	6	9	13	13	5	3	1	1	1	2	0	5	4	3	2	3	3	2	1	3	3	1	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:176951739G>A	uc003mhs.3	-	8	3233	c.1644C>T	c.(1642-1644)AAC>AAT	p.N548N	FAM193B_uc003mhr.2_Silent_p.N85N|FAM193B_uc003mht.2_Silent_p.N207N|FAM193B_uc003mhu.2_Silent_p.N260N|FAM193B_uc003mhv.2_Silent_p.N207N|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	581											0						TCACGAGCCCGTTCTCGGGGA	0.652													4	8					0	0	0	0	A	176951739	A	A	176951739	2	1	306	1	0	0	0	0	0	0	0	1	5553	1136	40	1		1	FAM193B	5	176951739	Silent	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	36200249	176951739	3963521	16	56493											
HIST1H2BM	8342	broad.mit.edu	37	chr6	27783137	27783137	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	tgcgcctactgctacccgggGaattggccaagcacgccgtg	7	7	13	14	4	0	0	0	0	0	0	0	1	0	1	4	3	5	2	4	3	4	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:27783137G>A	uc003njo.2	+	1	316	c.316G>A	c.(316-318)GAA>AAA	p.E106K	HIST1H2AJ_uc003njn.1_5'Flank	NM_003521	NP_003512	Q99879	H2B1M_HUMAN	histone cluster 1, H2bm	106					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(1)	1						GCTACCCGGGGAATTGGCCAA	0.622													7	60					0	0	0	0	A	27783137	A	A	27783137	3	1	306	1	0	0	0	0	1	0	0	0	7191	1175	41	2	318	2	HIST1H2BM	6	27783137	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08		27783137	143331930	17	56494											
TRIM27	5987	broad.mit.edu	37	chr6	28871857	28871857	+	Missense_Mutation	SNP	G	C	C	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	attcacctcctcaaggggagGtctccatggaatgaccatga	11	9	10	11	0	3	2	2	2	1	0	5	4	4	4	4	4	0	0	4	4	2	1			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:28871857G>C	uc003nlr.2	-	8	1891	c.1532C>G	c.(1531-1533)ACC>AGC	p.T511S	TRIM27_uc003nls.2_3'UTR|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	511					cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						TCAAGGGGAGGTCTCCATGGA	0.537			T	RET	papillary thyroid								9	60					0	0	0	0	C	28871857	C	C	28871857	3	2	306	1	0	0	0	0	1	0	0	0	16568	1261	44	4	13	4	TRIM27	6	28871857	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	1088720	28871857	142243210	18	56495											
VARS2	57176	broad.mit.edu	37	chr6	30888896	30888896	+	Nonsense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccttccaccagaagaactggCagcactggttttcccatatt	10	11	7	13	0	0	2	0	0	0	2	2	2	2	2	4	2	2	3	4	2	3	5			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:30888896C>T	uc003nsc.1	+	15	2166	c.1534C>T	c.(1534-1536)CAG>TAG	p.Q512*	VARS2_uc011dmx.1_Nonsense_Mutation_p.Q512*|VARS2_uc011dmy.1_Nonsense_Mutation_p.Q372*|VARS2_uc011dmz.1_Nonsense_Mutation_p.Q542*|VARS2_uc011dna.1_Nonsense_Mutation_p.Q510*|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'UTR|VARS2_uc010jsg.1_5'UTR|VARS2_uc010jsh.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	512					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						GAAGAACTGGCAGCACTGGTT	0.557													6	45					0	0	0	0	T	30888896	T	T	30888896	4	4	306	1	0	0	0	0	0	1	0	0	17192	711	25	4	1686	4	VARS2	6	30888896	Nonsense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	2017039	30888896	140226171	19	56496											
SLC44A4	80736	broad.mit.edu	37	chr6	31832499	31832499	+	Silent	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	0	0	0	0	0	0	0	0	ccgctggcgatgacataggcCcccaggatggaggtctggaa	9	6	15	11	2	1	1	0	1	1	0	1	5	1	4	3	6	0	1	3	6	2	1			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:31832499C>A	uc010jti.2	-	20	2007	c.1941G>T	c.(1939-1941)GGG>GGT	p.G647G	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	647	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	TGACATAGGCCCCCAGGATGG	0.597													7	79					8.12818e-05	0.000114685	1	0	A	31832499	A	A	31832499	2	1	306	1	0	0	0	0	0	0	0	1	14702	610	22	4		4	SLC44A4	6	31832499	Silent	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	943603	31832499	139282568	20	56497											
DNAH8	1769	broad.mit.edu	37	chr6	38816439	38816440	+	Frame_Shift_Ins	INS	-	A	A																															ttagatacaatgctccatttINSaaaaaaaatatccagaattg																										TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:38816439_38816440insA	uc003ooe.1	+	35	5010_5011	c.4410_4411insA	c.(4408-4413)TTTAAAfs	p.F1470fs		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATGCTCCATTTAAAAAAAATAT	0.342													---	---	---								A	38816440	A	A	38816439	7	5	306	1	0	1	1	0	0	0	0	0	4629	1751	61	0	4540	0	DNAH8	6	38816439	Frame_Shift_Ins	INS	-	TCGA-IQ-7632-01A-11D-2078-08	6983940	38816439	132298628	21	56498											
DNAH8	1769	broad.mit.edu	37	chr6	38840791	38840791	+	Silent	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	acgttagctaatggagatcgCattcccatggcccctagttg	9	11	10	11	2	0	1	0	0	0	1	2	2	1	1	3	2	1	4	3	2	3	5			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:38840791C>T	uc003ooe.1	+	49	7296	c.6696C>T	c.(6694-6696)CGC>CGT	p.R2232R		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATGGAGATCGCATTCCCATGG	0.443													12	82					0	0	0	0	T	38840791	T	T	38840791	2	4	306	1	0	0	0	0	0	0	0	1	4629	697	25	4		4	DNAH8	6	38840791	Silent	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	24352	38840791	132274276	22	56499											
KIAA0776	23376	broad.mit.edu	37	chr6	96971059	96971059	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gcattgagattgttaataaaTtgattgctcagaaacagcta	15	13	8	5	0	1	3	1	2	0	2	1	4	1	3	0	0	3	4	0	0	5	7			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:96971059T>C	uc003por.2	+	2	163	c.115T>C	c.(115-117)TTG>CTG	p.L39L	KIAA0776_uc010kck.2_RNA	NM_015323	NP_056138	O94874	UFL1_HUMAN	hypothetical protein LOC23376	39	Required for E3 UFM1-protein ligase activity.				negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)		TGTTAATAAATTGATTGCTCA	0.368													5	88					0	0	0	0	C	96971059	C	C	96971059	2	2	306	1	0	0	0	0	0	0	0	1	8232	1490	52	5		5	KIAA0776	6	96971059	Silent	SNP	T	TCGA-IQ-7632-01A-11D-2078-08	58130268	96971059	74144008	23	56500											
HEY2	23493	broad.mit.edu	37	chr6	126080842	126080842	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtggccgcggccacagccaTcagcccgcccttgtcagtat	7	7	11	16	3	2	0	2	0	0	0	2	0	2	0	5	2	2	1	5	2	1	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:126080842T>G	uc003qad.2	+	5	1099	c.908T>G	c.(907-909)ATC>AGC	p.I303S	HEY2_uc011ebr.1_Missense_Mutation_p.I257S	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	303					negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		GCCACAGCCATCAGCCCGCCC	0.622													10	106					0	0	0	0	G	126080842	G	G	126080842	3	3	306	1	0	0	0	0	1	0	0	0	7118	1435	50	5	926	5	HEY2	6	126080842	Missense_Mutation	SNP	T	TCGA-IQ-7632-01A-11D-2078-08	29109783	126080842	45034225	24	56501											
AKAP9	10142	broad.mit.edu	37	chr7	91570433	91570435	+	In_Frame_Del	DEL	AGA	-	-																															catggaggacgaggagagacAgaagaagctggaggccggca																										TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr7:91570433_91570435delAGA	uc003ulg.2	+	1	245_247	c.20_22delAGA	c.(19-24)CAGAAG>CAG	p.K9del	AKAP9_uc003uld.3_In_Frame_Del_p.K9del|AKAP9_uc003ule.2_In_Frame_Del_p.K9del|AKAP9_uc003ulf.2_In_Frame_Del_p.K9del	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	9					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAGGAGAGACAGAAGAAGCTGGA	0.635			T	BRAF	papillary thyroid								---	---	---								-	91570435	-	-	91570433	7	5	306	1	0	1	0	1	0	0	0	0	459	188	7	0	22	0	AKAP9	7	91570433	In_Frame_Del	DEL	AGA	TCGA-IQ-7632-01A-11D-2078-08		91570433	67568230	25	56502											
FAM49B	51571	broad.mit.edu	37	chr8	130874554	130874554	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	ccccatgccttctcttgcaaCttctcatctgctggatgctg	5	14	7	15	0	3	0	1	0	3	0	5	1	3	1	3	1	5	3	3	1	1	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr8:130874554C>G	uc003yss.2	-	8	771	c.222G>C	c.(220-222)AAG>AAC	p.K74N	FAM49B_uc003yst.2_Missense_Mutation_p.K74N|FAM49B_uc003ysu.2_Missense_Mutation_p.K74N|FAM49B_uc003ysv.2_Intron|FAM49B_uc003ysw.2_Missense_Mutation_p.K74N|FAM49B_uc003ysx.2_Missense_Mutation_p.K74N|FAM49B_uc003ysy.1_Missense_Mutation_p.K74N	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	hypothetical protein LOC51571	74											0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TCTCTTGCAACTTCTCATCTG	0.328													8	87					0	0	0	0	G	130874554	G	G	130874554	3	3	306	1	0	0	0	0	1	0	0	0	5608	564	20	4	784	4	FAM49B	8	130874554	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08		130874554	15489468	26	56503											
PAX5	5079	broad.mit.edu	37	chr9	37015073	37015073	+	Missense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ccggtccctgatctcccaggCaaacatggtgggattttggc	7	10	12	12	1	1	1	0	1	1	0	3	2	2	2	3	5	1	1	3	5	1	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr9:37015073C>A	uc003zzo.1	-	3	779	c.331G>T	c.(331-333)GCC>TCC	p.A111S	PAX5_uc011lpw.1_Missense_Mutation_p.A111S|PAX5_uc011lpx.1_Intron|PAX5_uc011lpy.1_Missense_Mutation_p.A3S|PAX5_uc010mls.1_Missense_Mutation_p.A111S|PAX5_uc011lpz.1_Missense_Mutation_p.A111S|PAX5_uc011lqa.1_Missense_Mutation_p.A3S|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.A111S|PAX5_uc010mlp.1_Missense_Mutation_p.A111S|PAX5_uc011lqc.1_Missense_Mutation_p.A111S|PAX5_uc010mlr.1_Missense_Mutation_p.A111S|PAX5_uc011lqd.1_Intron|PAX5_uc011lqe.1_RNA|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_RNA	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	111	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(32)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		ATCTCCCAGGCAAACATGGTG	0.547			T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								8	179					0.00448238	0.00584412	1	0	A	37015073	A	A	37015073	3	1	306	1	0	0	0	0	1	0	0	0	11536	710	25	4	876	4	PAX5	9	37015073	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08		37015073	104198358	27	56504											
KIAA1529	57653	broad.mit.edu	37	chr9	100127991	100127991	+	Missense_Mutation	SNP	G	T	T	0	0	1	0	0	0	0	1	0	0	0	1	0	1	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atcttgaccctcctctgggaGagcagtgagaacctgctgac	9	9	11	12	0	2	4	0	3	2	2	3	6	3	4	3	1	3	2	3	1	1	1			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr9:100127991G>T	uc011lut.1	+	42	5339	c.4566G>T	c.(4564-4566)GAG>GAT	p.E1522D	KIAA1529_uc004axe.1_Missense_Mutation_p.E1328D|KIAA1529_uc004axg.1_Missense_Mutation_p.E1383D|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.E476D|MIR1302-8_hsa-mir-1302-8|MI0006369_5'Flank	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TCCTCTGGGAGAGCAGTGAGA	0.562													16	54					1.99824e-07	2.94026e-07	1	0	T	100127991	T	T	100127991	3	4	306	1	0	0	0	0	1	0	0	0	8279	933	33	2	4106	2	KIAA1529	9	100127991	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	63112918	100127991	41085440	28	56505											
C10orf107	219621	broad.mit.edu	37	chr10	63450358	63450358	+	Silent	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	atgttctactctgccagggaAgaaattgtgataggaactga	13	11	11	6	0	2	3	0	2	2	1	2	5	2	5	1	2	3	1	1	2	5	4			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr10:63450358A>G	uc010qik.1	+	4	572	c.267A>G	c.(265-267)GAA>GAG	p.E89E		NM_173554	NP_775825	Q8IVU9	CJ107_HUMAN	hypothetical protein LOC219621	89											0	Prostate(12;0.016)					CTGCCAGGGAAGAAATTGTGA	0.343													7	46					0	0	0	0	G	63450358	G	G	63450358	2	3	306	1	0	0	0	0	0	0	0	1	1587	69	3	5		5	C10orf107	10	63450358	Silent	SNP	A	TCGA-IQ-7632-01A-11D-2078-08		63450358	72084389	29	56506											
SYT9	143425	broad.mit.edu	37	chr11	7439283	7439283	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ccttgaatcctgtttacaacGaagccatagtctttgatgtc	10	14	7	10	1	1	2	0	2	1	0	3	3	2	2	3	0	3	1	3	0	5	5			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:7439283G>A	uc001mfe.2	+	5	1498	c.1261G>A	c.(1261-1263)GAA>AAA	p.E421K	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	421	Cytoplasmic (Potential).|C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TGTTTACAACGAAGCCATAGT	0.468													6	61					0	0	0	0	A	7439283	A	A	7439283	3	1	306	1	0	0	0	0	1	0	0	0	15547	1059	37	1	1279	1	SYT9	11	7439283	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08		7439283	127567233	30	56507											
OR4C16	219428	broad.mit.edu	37	chr11	55339695	55339695	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agtgtttgttatttttttgcGtctctacttgggaacactgt	6	20	9	6	1	1	0	0	0	1	0	2	1	1	1	0	1	3	2	0	1	3	7			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:55339695G>A	uc010rih.1	+	1	92	c.92G>A	c.(91-93)CGT>CAT	p.R31H		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				ATTTTTTTGCGTCTCTACTTG	0.368													7	89					0	0	0	0	A	55339695	A	A	55339695	3	1	306	1	0	0	0	0	1	0	0	0	11103	1145	40	1	94	1	OR4C16	11	55339695	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	47900412	55339695	79666821	31	56508											
WDR74	54663	broad.mit.edu	37	chr11	62606655	62606655	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	gtctctgaccctggaatatgCcatcctcggtgctgaagtgc	7	11	11	12	1	1	2	0	2	1	0	4	3	2	3	3	2	3	1	3	2	3	1			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:62606655C>T	uc001nvm.1	-	4	392	c.224G>A	c.(223-225)GGC>GAC	p.G75D	WDR74_uc001nvk.1_Missense_Mutation_p.G18D|WDR74_uc001nvl.1_Missense_Mutation_p.G75D|WDR74_uc001nvn.1_Missense_Mutation_p.G127D|WDR74_uc009yoi.1_Missense_Mutation_p.G75D|WDR74_uc010rmk.1_Missense_Mutation_p.G75D	NM_018093	NP_060563	Q6RFH5	WDR74_HUMAN	WD repeat domain 74	75	WD 1.					nucleolus				ovary(1)	1						CTGGAATATGCCATCCTCGGT	0.652													4	46					0	0	0	0	T	62606655	T	T	62606655	3	4	306	1	0	0	0	0	1	0	0	0	17392	739	26	4	969	4	WDR74	11	62606655	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	7266960	62606655	72399861	32	56509											
SESN3	143686	broad.mit.edu	37	chr11	94911920	94911920	+	Missense_Mutation	SNP	T	G	G	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cttctcctcgtctggcaaagTcttcatacccaaaaccaggg	10	10	7	14	1	4	0	1	0	3	0	6	0	4	0	3	2	2	1	3	2	4	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:94911920T>G	uc001pfk.1	-	7	1232	c.1010A>C	c.(1009-1011)GAC>GCC	p.D337A	SESN3_uc010rug.1_Missense_Mutation_p.D198A	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	337					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TCTGGCAAAGTCTTCATACCC	0.363													7	46					0	0	0	0	G	94911920	G	G	94911920	3	3	306	1	0	0	0	0	1	0	0	0	14191	1667	58	5	484	5	SESN3	11	94911920	Missense_Mutation	SNP	T	TCGA-IQ-7632-01A-11D-2078-08	32305265	94911920	40094596	33	56510											
ST8SIA1	6489	broad.mit.edu	37	chr12	22408274	22408274	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	cactcttcttcagaatcccaCcatttcccaccaccgcgcat	9	10	3	19	2	3	1	1	0	2	1	5	1	5	1	5	0	0	1	5	0	1	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:22408274C>T	uc001rfo.3	-	3	913	c.431G>A	c.(430-432)GGT>GAT	p.G144D	ST8SIA1_uc009zix.2_Intron	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	144	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						CAGAATCCCACCATTTCCCAC	0.517													10	100					0	0	0	0	T	22408274	T	T	22408274	3	4	306	1	0	0	0	0	1	0	0	0	15297	507	18	4	651	4	ST8SIA1	12	22408274	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08		22408274	111443621	34	56511											
MLL2	8085	broad.mit.edu	37	chr12	49445626	49445626	+	Nonsense_Mutation	SNP	C	A	A	0	0	0	1	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	tggtggggaaaggggagactCctcaggtggaggggacagag	10	5	21	5	0	1	2	1	0	0	2	2	6	2	5	1	9	0	0	1	9	1	0			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:49445626C>A	uc001rta.3	-	10	1840	c.1840G>T	c.(1840-1842)GAG>TAG	p.E614*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	614	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGGGGAGACTCCTCAGGTGGA	0.602			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			9	49					2.17888e-05	3.16091e-05	1	0	A	49445626	A	A	49445626	4	1	306	1	0	0	0	0	0	1	0	0	9674	864	30	2	14953	2	MLL2	12	49445626	Nonsense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	27037352	49445626	84406269	35	56512											
KIF5A	3798	broad.mit.edu	37	chr12	57958726	57958726	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	aagacaaatctgtccgtgcaCgaggacaagaaccgggtgcc	13	5	12	11	3	1	2	0	0	1	2	2	4	2	3	3	2	3	1	3	2	4	0	rs143178113		TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:57958726C>T	uc001sor.1	+	6	679	c.471C>T	c.(469-471)CAC>CAT	p.H157H	KIF5A_uc010srr.1_Silent_p.H68H	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	157	Kinesin-motor.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						TGTCCGTGCACGAGGACAAGA	0.532													6	33					0	0	0	0	T	57958726	T	T	57958726	2	4	306	1	0	0	0	0	0	0	0	1	8344	535	19	1		1	KIF5A	12	57958726	Silent	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	8513100	57958726	75893169	36	56513											
THAP2	83591	broad.mit.edu	37	chr12	72070612	72070612	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	1	0	0	1	0	1	0	0	0	cctatggaggcaaaaaagagGatcattaaactggaaaaaga	20	6	10	5	0	1	2	1	0	0	2	1	5	1	5	1	4	1	1	1	4	8	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:72070612G>A	uc001swq.2	+	3	917	c.411G>A	c.(409-411)AGG>AGA	p.R137R		NM_031435	NP_113623	Q9H0W7	THAP2_HUMAN	THAP domain containing, apoptosis associated	137						nucleolus	DNA binding|metal ion binding			ovary(1)	1						CAAAAAAGAGGATCATTAAAC	0.383													6	65					0	0	0	0	A	72070612	A	A	72070612	2	1	306	1	0	0	0	0	0	0	0	1	15910	1165	41	2		2	THAP2	12	72070612	Silent	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	14111886	72070612	61781283	37	56514											
SACS	26278	broad.mit.edu	37	chr13	23914846	23914846	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	atcctttagtacttctatatCagggtcaaagagttcaccag	12	13	7	9	0	4	1	3	0	1	1	5	1	5	1	2	1	1	2	2	1	5	7			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr13:23914846C>G	uc001uon.2	-	10	3758	c.3169G>C	c.(3169-3171)GAT>CAT	p.D1057H	SACS_uc001uoo.2_Missense_Mutation_p.D910H|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1057					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ACTTCTATATCAGGGTCAAAG	0.373													5	115					0	0	0	0	G	23914846	G	G	23914846	3	3	306	1	0	0	0	0	1	0	0	0	13869	826	29	2	10574	2	SACS	13	23914846	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08		23914846	91255032	38	56515											
SMOC1	64093	broad.mit.edu	37	chr14	70444647	70444647	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	cacccaaggttcagtcaccgAcaagcccttgagccagggta	11	6	10	14	1	2	1	2	1	0	0	2	2	2	1	4	2	2	2	4	2	3	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr14:70444647A>G	uc001xls.1	+	5	744	c.491A>G	c.(490-492)GAC>GGC	p.D164G	SMOC1_uc001xlt.1_Missense_Mutation_p.D164G	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	164					cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		TCAGTCACCGACAAGCCCTTG	0.433													6	56					0	0	0	0	G	70444647	G	G	70444647	3	3	306	1	0	0	0	0	1	0	0	0	14865	275	10	5	509	5	SMOC1	14	70444647	Missense_Mutation	SNP	A	TCGA-IQ-7632-01A-11D-2078-08		70444647	36904893	39	56516											
EFTUD1	79631	broad.mit.edu	37	chr15	82444535	82444535	+	Nonsense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	ttctggaaggggcatggctcGaacactgagcgtggcaagtt	9	9	15	8	2	1	1	0	1	1	0	2	3	1	2	0	5	2	4	0	5	3	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr15:82444535G>A	uc002bgt.1	-	18	2429	c.2260C>T	c.(2260-2262)CGA>TGA	p.R754*	EFTUD1_uc002bgs.1_Nonsense_Mutation_p.R125*|EFTUD1_uc002bgu.1_Nonsense_Mutation_p.R703*	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	754					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						GGCATGGCTCGAACACTGAGC	0.438													7	75					0	0	0	0	A	82444535	A	A	82444535	4	1	306	1	0	0	0	0	0	1	0	0	4982	1066	37	1	1114	1	EFTUD1	15	82444535	Nonsense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08		82444535	20086857	40	56517											
SLC28A1	9154	broad.mit.edu	37	chr15	85447424	85447424	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	gtgtccttcgcaggaatctgCgtgttcgtcgctctcctctt	3	15	10	13	4	3	0	0	0	3	0	8	1	4	1	2	1	1	3	2	1	1	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr15:85447424C>T	uc002blg.2	+	7	760	c.558C>T	c.(556-558)TGC>TGT	p.C186C	SLC28A1_uc010upd.1_Silent_p.C108C|SLC28A1_uc010bnb.2_Silent_p.C186C|SLC28A1_uc010upe.1_Silent_p.C186C|SLC28A1_uc010upf.1_Silent_p.C186C|SLC28A1_uc010upg.1_Silent_p.C186C	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	186	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGGAATCTGCGTGTTCGTCG	0.597													5	87					0	0	0	0	T	85447424	T	T	85447424	2	4	306	1	0	0	0	0	0	0	0	1	14595	776	27	1		1	SLC28A1	15	85447424	Silent	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	3002889	85447424	17083968	41	56518											
PLK1	5347	broad.mit.edu	37	chr16	23695252	23695252	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tcagacagatcccactgcccGcccaaccattaacgagctgc	11	6	7	17	2	1	2	1	0	0	2	2	3	2	2	4	0	5	1	4	0	2	1			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr16:23695252G>A	uc002dlz.1	+	5	931	c.878G>A	c.(877-879)CGC>CAC	p.R293H		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	293	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		CCCACTGCCCGCCCAACCATT	0.547													12	250					0	0	0	0	A	23695252	A	A	23695252	3	1	306	1	0	0	0	0	1	0	0	0	12149	1087	38	1	896	1	PLK1	16	23695252	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08		23695252	66659501	42	56519											
CNOT1	23019	broad.mit.edu	37	chr16	58583721	58583721	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	1	0	1	0	0	0	1	0	1	0	0	0	0	0	0	0	0	0	1	1	0	1	1	0	caggctatgaaagtttggctCaatactgactctcttcataa	12	13	7	9	0	3	2	2	2	1	0	4	2	3	2	0	2	1	3	0	2	5	5			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr16:58583721C>G	uc002env.2	-	25	3717	c.3424G>C	c.(3424-3426)GAG>CAG	p.E1142Q	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.E1137Q|CNOT1_uc002enx.2_Missense_Mutation_p.E1142Q|CNOT1_uc002enz.1_Missense_Mutation_p.E571Q|CNOT1_uc010vik.1_Missense_Mutation_p.E138Q|SNORA46_uc002eny.1_5'Flank	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1142					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AAGTTTGGCTCAATACTGACT	0.393													6	87					0	0	0	0	G	58583721	G	G	58583721	3	3	306	1	0	0	0	0	1	0	0	0	3632	835	29	2	4028	2	CNOT1	16	58583721	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	34888469	58583721	31771032	43	56520											
ZFHX3	463	broad.mit.edu	37	chr16	72828433	72828433	+	Silent	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	ttggctttgaagagcgctctGcaaaaagggcatctcctgtg	9	11	12	9	1	2	2	0	1	2	1	3	2	2	2	1	2	2	4	1	2	3	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr16:72828433G>A	uc002fck.2	-	9	8821	c.8148C>T	c.(8146-8148)TGC>TGT	p.C2716C	ZFHX3_uc002fcl.2_Silent_p.C1802C	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2716	C2H2-type 20.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				AGAGCGCTCTGCAAAAAGGGC	0.562													17	65					0	0	0	0	A	72828433	A	A	72828433	2	1	306	1	0	0	0	0	0	0	0	1	17701	1311	46	4		4	ZFHX3	16	72828433	Silent	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	14244712	72828433	17526320	44	56521											
SC65	10609	broad.mit.edu	37	chr17	39967445	39967445	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	cgacgtccagcatcccctgaTagtagttgagatacttggcg	9	10	11	11	3	0	2	0	2	0	1	2	4	2	2	3	1	2	3	3	1	3	5			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr17:39967445T>C	uc002hxt.2	-	2	838	c.554A>G	c.(553-555)TAT>TGT	p.Y185C	FKBP10_uc002hxv.2_5'Flank|SC65_uc002hxu.2_Missense_Mutation_p.Y276C	NM_006455	NP_006446	Q92791	SC65_HUMAN	synaptonemal complex protein SC65	185					synaptonemal complex assembly	nucleolus|synaptonemal complex	binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.149)		CATCCCCTGATAGTAGTTGAG	0.647													27	233					0	0	0	0	C	39967445	C	C	39967445	3	2	306	1	0	0	0	0	1	0	0	0	13932	1406	49	5	787	5	SC65	17	39967445	Missense_Mutation	SNP	T	TCGA-IQ-7632-01A-11D-2078-08		39967445	41227765	45	56522											
ABCC3	8714	broad.mit.edu	37	chr17	48761081	48761082	+	Frame_Shift_Del	DEL	GA	-	-																															ccgggcctagacctggtgctGagagacctgagtctgcatgt																										TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr17:48761081_48761082delGA	uc002isl.2	+	27	3998_3999	c.3918_3919delGA	c.(3916-3921)CTGAGAfs	p.L1306fs	ABCC3_uc002isn.2_Frame_Shift_Del_p.L60fs	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1306_1307	Cytoplasmic (By similarity).|ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	ACCTGGTGCTGAGAGACCTGAG	0.644													---	---	---								-	48761082	-	-	48761081	7	5	306	1	0	1	0	1	0	0	0	0	54	1277	45	0	4108	0	ABCC3	17	48761081	Frame_Shift_Del	DEL	GA	TCGA-IQ-7632-01A-11D-2078-08	8793636	48761081	32434129	46	56523											
C18orf1	753	broad.mit.edu	37	chr18	13645527	13645527	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	gtgatgggccaccacccaggCgcctctttcctccatcacca	7	8	8	18	1	2	1	1	1	1	0	4	1	4	1	7	2	0	0	7	2	0	1			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr18:13645527C>T	uc002ksa.2	+	7	1460	c.792C>T	c.(790-792)GGC>GGT	p.G264G	C18orf1_uc002ksb.2_Silent_p.G246G|C18orf1_uc002kse.2_Silent_p.G227G|C18orf1_uc002ksf.2_Silent_p.G209G|C18orf1_uc002ksg.1_Silent_p.G187G|C18orf1_uc002ksh.1_Silent_p.G206G|C18orf1_uc002ksi.1_Silent_p.G188G	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	264	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		ACCACCCAGGCGCCTCTTTCC	0.597													9	60					0	0	0	0	T	13645527	T	T	13645527	2	4	306	1	0	0	0	0	0	0	0	1	1903	755	27	1		1	C18orf1	18	13645527	Silent	SNP	C	TCGA-IQ-7632-01A-11D-2078-08		13645527	64431721	47	56524											
TCEB3B	51224	broad.mit.edu	37	chr18	44559510	44559510	+	Missense_Mutation	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	tgctcaggcaggggttggccCgcttctcagggagccagcga	6	7	16	12	2	2	0	2	0	1	0	3	2	2	1	2	5	3	4	2	5	0	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr18:44559510C>T	uc002lcr.1	-	1	2479	c.2126G>A	c.(2125-2127)CGG>CAG	p.R709Q	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	709					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GGGGTTGGCCCGCTTCTCAGG	0.547													5	62					0	0	0	0	T	44559510	T	T	44559510	3	4	306	1	0	0	0	0	1	0	0	0	15748	652	23	1	139	1	TCEB3B	18	44559510	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	30913983	44559510	33517738	48	56525											
LPHN1	22859	broad.mit.edu	37	chr19	14268749	14268749	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tgaggtggctgcaggcacacGtggtatgggtcttgttggac	6	11	17	7	1	1	1	0	1	1	0	1	2	1	2	0	6	1	5	0	6	1	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr19:14268749G>A	uc010xnn.1	-	14	2791	c.2495C>T	c.(2494-2496)ACG>ATG	p.T832M	LPHN1_uc010xno.1_Missense_Mutation_p.T827M|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	832	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						GCAGGCACACGTGGTATGGGT	0.597													5	61					0	0	0	0	A	14268749	A	A	14268749	3	1	306	1	0	0	0	0	1	0	0	0	8965	1145	40	1	1973	1	LPHN1	19	14268749	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08		14268749	44860234	49	56526											
ZNF540	163255	broad.mit.edu	37	chr19	38102814	38102814	+	Silent	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	catcagaaaattcatactggTgaaaaatcctgtaaatgtga	17	11	7	6	0	2	3	2	2	0	1	3	3	3	3	1	1	1	1	1	1	7	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr19:38102814T>C	uc002ogq.2	+	5	965	c.633T>C	c.(631-633)GGT>GGC	p.G211G	ZNF540_uc002ogu.2_Silent_p.G211G|ZNF540_uc010efq.2_Silent_p.G179G	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	211					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCATACTGGTGAAAAATCCT	0.338													3	50					0	0	0	0	C	38102814	C	C	38102814	2	2	306	1	0	0	0	0	0	0	0	1	18042	1683	59	5		5	ZNF540	19	38102814	Silent	SNP	T	TCGA-IQ-7632-01A-11D-2078-08	23834065	38102814	21026169	50	56527											
KIF3B	9371	broad.mit.edu	37	chr20	30897727	30897727	+	Silent	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	gtgaagaaccccaaagggacGgcccatgaaatgcccaagac	15	3	11	12	1	0	4	0	2	0	2	0	5	0	5	4	2	2	0	4	2	5	0			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:30897727G>A	uc002wxq.2	+	2	314	c.147G>A	c.(145-147)ACG>ACA	p.T49T	KIF3B_uc010ztv.1_Silent_p.T49T|KIF3B_uc010ztw.1_Silent_p.T49T	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	49	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCAAAGGGACGGCCCATGAAA	0.512													5	52					0	0	0	0	A	30897727	A	A	30897727	2	1	306	1	0	0	0	0	0	0	0	1	8340	1103	39	1		1	KIF3B	20	30897727	Silent	SNP	G	TCGA-IQ-7632-01A-11D-2078-08		30897727	32127793	51	56528											
BPIL3	128859	broad.mit.edu	37	chr20	31622901	31622901	+	Missense_Mutation	SNP	T	C	C	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atctagcatgctccccaagaTggtcaacaagttcctggaca	12	9	8	12	0	2	1	1	0	1	1	4	2	4	2	3	2	3	3	3	2	4	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:31622901T>C	uc010zuc.1	+	5	467	c.467T>C	c.(466-468)ATG>ACG	p.M156T	BPIL3_uc010zud.1_Missense_Mutation_p.M95T	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	156						extracellular region	lipid binding			ovary(1)|pancreas(1)	2						CTCCCCAAGATGGTCAACAAG	0.577													11	52					0	0	0	0	C	31622901	C	C	31622901	3	2	306	1	0	0	0	0	1	0	0	0	1498	1464	51	5	485	5	BPIL3	20	31622901	Missense_Mutation	SNP	T	TCGA-IQ-7632-01A-11D-2078-08	725174	31622901	31402619	52	56529											
TOMM34	10953	broad.mit.edu	37	chr20	43585027	43585027	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	1	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	aattacccttggccacttacGaagtgcaatctttgatgcag	11	12	8	10	1	1	1	0	1	1	0	1	2	1	1	2	1	4	2	2	1	5	4			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:43585027G>A	uc002xmy.2	-	2	367	c.227C>T	c.(226-228)TCA>TTA	p.S76L	PABPC1L_uc002xmx.2_Intron|TOMM34_uc002xmz.2_RNA	NM_006809	NP_006800	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	76	TPR 2.				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding				0		Myeloproliferative disorder(115;0.0122)				GGCCACTTACGAAGTGCAATC	0.468													14	203					0	0	0	0	A	43585027	A	A	43585027	3	1	306	1	0	0	0	0	1	0	0	0	16423	1072	37	1	726	1	TOMM34	20	43585027	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	11962126	43585027	19440493	53	56530											
SYCP2	10388	broad.mit.edu	37	chr20	58471566	58471566	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	gatgcttcagacatttttctTttgctaggagtagttttctg	7	19	9	6	0	3	1	1	0	2	1	3	3	3	2	0	1	2	4	0	1	2	9			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:58471566T>A	uc002yaz.2	-	18	1561	c.1422A>T	c.(1420-1422)AAA>AAT	p.K474N		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	474					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			ACATTTTTCTTTTGCTAGGAG	0.318													7	38					0	0	0	0	A	58471566	A	A	58471566	3	1	306	1	0	0	0	0	1	0	0	0	15498	1838	64	5	3278	5	SYCP2	20	58471566	Missense_Mutation	SNP	T	TCGA-IQ-7632-01A-11D-2078-08	14886539	58471566	4553954	54	56531											
CCT8L2	150160	broad.mit.edu	37	chr22	17072504	17072504	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agacctagcttgaatcaccaCgatgccatacttgtccgcca	11	9	7	14	2	1	2	1	1	0	1	2	3	2	2	5	0	3	1	5	0	3	4			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr22:17072504C>G	uc002zlp.1	-	1	1197	c.937G>C	c.(937-939)GTG>CTG	p.V313L		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	313					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGAATCACCACGATGCCATAC	0.557													14	132					0	0	0	0	G	17072504	G	G	17072504	3	3	306	1	0	0	0	0	1	0	0	0	2976	536	19	3	740	3	CCT8L2	22	17072504	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08		17072504	34232062	55	56532											
C22orf42	150297	broad.mit.edu	37	chr22	32548591	32548591	+	Silent	SNP	C	T	T	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	tccacaccgccgtgtgcagaCgcctgcacatcttcagtggg	7	8	11	15	3	2	1	1	0	1	1	3	1	3	1	4	1	2	2	4	1	0	1			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr22:32548591C>T	uc003amd.2	-	3	371	c.330G>A	c.(328-330)GCG>GCA	p.A110A		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	110										ovary(1)|skin(1)	2						CGTGTGCAGACGCCTGCACAT	0.493													6	46					0	0	0	0	T	32548591	T	T	32548591	2	4	306	1	0	0	0	0	0	0	0	1	2159	523	19	1		1	C22orf42	22	32548591	Silent	SNP	C	TCGA-IQ-7632-01A-11D-2078-08	15476087	32548591	18755975	56	56533											
SCML1	6322	broad.mit.edu	37	chrX	17768243	17768243	+	Missense_Mutation	SNP	C	G	G	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ggacccgatcctcagccgcaCtccgagtccagtgcatccct	7	7	9	18	3	1	0	1	0	0	0	5	3	5	1	6	1	2	2	6	1	0	0			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:17768243C>G	uc004cyb.2	+	6	858	c.533C>G	c.(532-534)ACT>AGT	p.T178S	SCML1_uc004cyc.2_Missense_Mutation_p.T151S|SCML1_uc004cyd.2_Missense_Mutation_p.T57S|SCML1_uc004cye.2_Missense_Mutation_p.T57S	NM_001037540	NP_001032629	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 isoform a	178					anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)	3	Hepatocellular(33;0.183)					CTCAGCCGCACTCCGAGTCCA	0.522													16	71					0	0	0	0	G	17768243	G	G	17768243	3	3	306	1	0	0	0	0	1	0	0	0	13974	565	20	4	554	4	SCML1	23	17768243	Missense_Mutation	SNP	C	TCGA-IQ-7632-01A-11D-2078-08		17768243	137502317	57	56534											
BRWD3	254065	broad.mit.edu	37	chrX	79932674	79932674	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	agaaccacaggtactttcagAacttaaactggatcctaact	15	10	6	10	0	1	2	1	0	0	2	2	3	2	3	2	2	5	1	2	2	6	4			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:79932674A>G	uc004edt.2	-	41	5106	c.4843T>C	c.(4843-4845)TCT>CCT	p.S1615P	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.S1211P|BRWD3_uc004edp.2_Missense_Mutation_p.S1444P|BRWD3_uc004edq.2_Missense_Mutation_p.S1211P|BRWD3_uc010nmj.1_Missense_Mutation_p.S1211P|BRWD3_uc004edr.2_Missense_Mutation_p.S1285P|BRWD3_uc004eds.2_Missense_Mutation_p.S1211P|BRWD3_uc004edu.2_Missense_Mutation_p.S1285P|BRWD3_uc004edv.2_Missense_Mutation_p.S1211P|BRWD3_uc004edw.2_Missense_Mutation_p.S1211P|BRWD3_uc004edx.2_Missense_Mutation_p.S1211P|BRWD3_uc004edy.2_Missense_Mutation_p.S1211P|BRWD3_uc004edz.2_Missense_Mutation_p.S1285P|BRWD3_uc004eea.2_Missense_Mutation_p.S1285P|BRWD3_uc004eeb.2_Missense_Mutation_p.S1211P|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1615										ovary(4)	4						GTACTTTCAGAACTTAAACTG	0.294													5	136					0	0	0	0	G	79932674	G	G	79932674	3	3	306	1	0	0	0	0	1	0	0	0	1531	246	9	5	569	5	BRWD3	23	79932674	Missense_Mutation	SNP	A	TCGA-IQ-7632-01A-11D-2078-08	62164431	79932674	75337886	58	56535											
PCDH11X	27328	broad.mit.edu	37	chrX	91132437	91132437	+	Missense_Mutation	SNP	A	G	G	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	atggcagggtgacatgcttcAcagatcatgaaatccctttc	11	11	9	10	0	2	3	2	2	0	1	4	3	3	3	1	2	1	2	1	2	1	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:91132437A>G	uc004efk.1	+	2	2043	c.1198A>G	c.(1198-1200)ACA>GCA	p.T400A	PCDH11X_uc004efl.1_Missense_Mutation_p.T400A|PCDH11X_uc004efo.1_Missense_Mutation_p.T400A|PCDH11X_uc010nmv.1_Missense_Mutation_p.T400A|PCDH11X_uc004efm.1_Missense_Mutation_p.T400A|PCDH11X_uc004efn.1_Missense_Mutation_p.T400A|PCDH11X_uc004efh.1_Missense_Mutation_p.T400A|PCDH11X_uc004efj.1_Missense_Mutation_p.T400A	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	400	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GACATGCTTCACAGATCATGA	0.418													9	121					0	0	0	0	G	91132437	G	G	91132437	3	3	306	1	0	0	0	0	1	0	0	0	11562	159	6	5	1204	5	PCDH11X	23	91132437	Missense_Mutation	SNP	A	TCGA-IQ-7632-01A-11D-2078-08	11199763	91132437	64138123	59	56536											
GPR112	139378	broad.mit.edu	37	chrX	135405364	135405364	+	Missense_Mutation	SNP	T	A	A	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	ctagggcactttctcaagaaTgagagcagcgaggttaaaag	14	8	12	7	1	1	2	1	1	1	2	2	4	1	2	0	2	2	3	0	2	5	3			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:135405364T>A	uc004ezu.1	+	5	789	c.498T>A	c.(496-498)AAT>AAA	p.N166K	GPR112_uc010nsb.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	166	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TTCTCAAGAATGAGAGCAGCG	0.448													7	129					0	0	0	0	A	135405364	A	A	135405364	3	1	306	1	0	0	0	0	1	0	0	0	6667	1461	51	5	504	5	GPR112	23	135405364	Missense_Mutation	SNP	T	TCGA-IQ-7632-01A-11D-2078-08	44272927	135405364	19865196	60	56537											
FLNA	2316	broad.mit.edu	37	chrX	153594747	153594747	+	Missense_Mutation	SNP	G	A	A	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	1	0	0	0	0	0	0	0	0	gctccaggccgggaccttggGctgtcactttgctggcgtca	4	10	14	13	2	2	0	2	0	0	0	3	1	3	1	3	4	1	3	3	4	0	2			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:153594747G>A	uc004fkk.2	-	8	1406	c.1157C>T	c.(1156-1158)GCC>GTC	p.A386V	FLNA_uc010nuu.1_Missense_Mutation_p.A386V	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	386	Filamin 2.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGACCTTGGGCTGTCACTTT	0.597													7	58					0	0	0	0	A	153594747	A	A	153594747	3	1	306	1	0	0	0	0	1	0	0	0	5965	1203	42	4	6950	4	FLNA	23	153594747	Missense_Mutation	SNP	G	TCGA-IQ-7632-01A-11D-2078-08	18189383	153594747	1675813	61	56538											
